# HG changeset patch
# User matteoc
# Date 1482399931 18000
# Node ID 68a3648c7d91d5738f65b6030d0b52a100550eee

Uploaded

diff -r 000000000000 -r 68a3648c7d91 annotate_ends/annotate_ends.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/annotate_ends/annotate_ends.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,21 @@
+<tool id="ends_annot" name="Sanger Ends Attacher" version="0.">
+ <description> Attach fosmid ends name based on similarity  </description>
+ <command> /home/inmare/galaxy/tools/annotate_ends/attach.tags.pl $ends $fos $blast $minid $alnl $out $table</command>
+ <description> "approved by the boss" </description>
+ <inputs>
+ 	<param name="ends" type="data" format="fasta" label="multifasta containing the ends of the fosmids" help="fasta only"/>
+ 	<param name="fos" type="data" format="fasta" label="multifasta of the assembled fosmid" help="fasta only "/>
+ 	<param name="blast" type="data" format="tabular" label="blast output" help="12 column output only"/>
+ 	<!--<param name="minid" type="integer" label="minimum identity" value="95"  help="identity cutoff"/>
+        <param name="alnl" type="integer" label="minimum alignment length" value="200"  help="minimum alignment length"/>-->
+
+ </inputs>
+ <outputs>
+ 	<data name="out" format="fasta" label="decorated fosmid file"/>
+ 	<data name="table" format="tabular" label="conversion table"/>
+ </outputs>
+ <test/>
+ <help>
+When Sanger sequencing of the fosmid was performed, assembled fosmid might be assigned to their putative clones by sequence similarity. This tool is designed to assist in this process parsing blastN output files. In order for the tool to work properly Sanger ends need to be provided in a single fasta files, and sequences need to be named according to the following convention: "fosmid name" followed by "_" and "F" for forward or "R" for reverse. The fosmid fasta file needs to be used as a query and the search must be performed against a database containing all the contigs derived from the assembly of the fosmid. This tool requires the "standard" (12 column) output from blastN, any other format might cause major flaws.  The output consist in a new fasta file, where prefixes corresponding to fosmid names as provided in the input file are appended to contigs names. The prefix Unf (for unassigned fosmid) is appended to contigs showing no significant similarity to fosmids ends. Minimum alignment length and identity cut-off need to be provided in input, as a rule of thumb alignment length cutoff should be set to about half of the length of the Sanger sequences and identity cutoff should be above 90%.
+ </help>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 annotate_ends/attach.tags.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/annotate_ends/attach.tags.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,129 @@
+#!/usr/bin/perl -w
+use strict;
+
+my $fos_file=shift;
+my $fosS=read_fa($fos_file);
+
+my $cont_file=shift;
+my $contS=read_fa($cont_file);
+
+my $bfile=shift;
+my %best=();
+
+my $sim_coff=shift;
+my $len_coff=shift;
+
+my $out_name=shift;
+open(OUT,">$out_name");
+
+my $out_table=shift;
+open(TABLE,">$out_table");
+
+open(IN,$bfile);
+while(<IN>)
+{
+	next if $_=~/\#/;
+	my ($in,$node,$ident,$alnL,$rs,$re,$score)=(split(/\s+/))[0,1,2,3,8,9,11];
+	next unless $alnL>=$len_coff;
+	next unless $ident>=$sim_coff;
+	unless ($best{$in})
+	{
+		if ($re<$rs)
+		{
+			my $tm=$re;
+			$re=$rs;
+			$rs=$tm
+		}
+		$best{$in}=[$node,$score,$rs,$re,$alnL];
+		print TABLE "$in $node $rs $re\n";
+	}else{
+		next unless $score> $best{$in}[1];
+		$best{$in}=[$node,$score,$rs,$re,$alnL];
+	}
+	
+}
+
+my %addT=();
+
+foreach my $best (keys %best)
+{
+	my $node=$best{$best}[0];
+	my $rs=$best{$best}[2];
+	my $re=$best{$best}[3];
+	my $alnL=$best{$best}[4];
+	my $relL=$alnL/length($fosS->{$best});
+	my $lseq=length($contS->{$node});
+	my $a=$lseq-$re;
+	print TABLE "Add $node $best $rs $a $relL\n";
+	if (($rs<=1500 || ($a)<=1500)) #&& $relL>0.35)
+	{
+		#print TABLE "Add $node $best $rs $a $relL\n";
+		push(@{$addT{$node}},$best);
+	}else{
+		#print TABLE "Discard $node $best $rs $a $relL\n";
+	}	
+	
+}
+my $unF=0;
+foreach my $seq (sort keys %$contS)
+{
+	my $tag="";
+	unless ($addT{$seq})
+	{
+		$unF++;
+		$tag="unf$unF";
+	}else{
+		my @adds=@{$addT{$seq}};
+		if ($#adds==1)
+		{	
+			my $t=$adds[0];
+			$t=(split(/\_/,$t))[0];
+			$tag.=$t."_FR";
+		}else{
+			foreach my $t (@{$addT{$seq}})
+                        {
+                                $tag.="$t";
+                        }
+	
+		}
+	}
+	my $SEQ=form($contS->{$seq},80);
+	print OUT ">$tag\n$SEQ\n";
+	print TABLE "$seq\t$tag\n";
+}
+
+
+
+sub read_fa
+{
+	my $file=$_[0];
+	my $seqF;
+	my $id="";
+	open(IN,$file);
+	while(<IN>)
+	{
+		chomp;
+		if ($_=~/^>(.*)/)
+		{
+			$id=$1;
+			$id=(split(/\s+/,$id))[0];
+		}else{
+			$seqF->{$id}.=$_;
+		}
+	}
+	return $seqF;
+}
+
+sub form
+{
+        my $string=$_[0];
+        my $len=$_[1];
+        my $outS="";
+        for (my $i=0;$i<=length($string);$i+=$len)
+        {
+                $outS.=substr($string,$i,$len)."\n";
+        }
+        #print "A:$outS";
+        #        #$outS=~s/\s+//g;
+        return $outS;
+}
diff -r 000000000000 -r 68a3648c7d91 de_prokka/de_prokka.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/de_prokka/de_prokka.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,49 @@
+#!/usr/bin/perl -w
+use strict;
+my $fas_file=shift;
+my $ann_file=shift;
+my $out_file=shift;
+
+open(OUT,">$out_file");
+
+my %seqS=();
+my $id="";
+open(IN,$fas_file);
+while(<IN>)
+{
+	if ($_=~/^>(.*)/)
+	{
+		$id=$1;
+		$id=(split(/\s+/,$id))[0];
+	}else{
+		$seqS{$id}.=$_;
+	}
+}
+
+my %decode=();
+open(IN,$ann_file);
+while(<IN>)
+{
+	last if $_=~/^\#\#FASTA/;
+	next if $_=~/^\#/;
+	my ($id1,$id2)=(split(/\t/))[0,-1];
+	$id2=(split(/\;/,$id2))[0];
+	my @vl=(split(/\_/,$id1));
+	$id1="";
+	foreach my $v (@vl)
+	{
+		if ($v eq "length")
+		{
+			chop($id1);
+			last;
+		}
+		$id1.="$v\_"; 
+	}
+	$id2=~s/ID=//;
+	$decode{$id2}=$id1;
+}
+foreach my $seq (sort keys %seqS)
+{
+	print OUT ">$decode{$seq}\z\z\z$seq\n$seqS{$seq}\n";
+}
+
diff -r 000000000000 -r 68a3648c7d91 de_prokka/de_prokka.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/de_prokka/de_prokka.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,15 @@
+<tool id="de_prokka" name="Prokka parser" version="0.">
+ <description>Parsing of Prokka output</description>
+ <command> /home/inmare/galaxy/tools/de_prokka/de_prokka.pl $prot $pfam $out</command>
+ <inputs>
+ 	<param name="prot" type="data" format="fasta" label="protein file by prokka" help="fasta only"/>
+ 	<param name="pfam" type="data" format="tabular" label="gff by prokka" help="this file should match the protein file"/>
+ </inputs>
+ <outputs>
+ 	<data name="out" ftype="data" format="fasta" label="annotated prokka file"/>
+ </outputs>
+ <test/>
+ <help>
+	This tool add information, derived from the gff file to the headers of a fasta files containing the sequences of proteins predicted by prokka. The operation is required in order to keep track of all the information related to the proteins and the scaffolds/contigs from which they are predicted, so that they are not lost in the functional annotation step. This tool is a simple parser based on regular expressions. Works only with Prokka version xxx. Any usage outside A-Game is discouraged
+ </help>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 de_prokka/fas
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/de_prokka/fas	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,2151 @@
+>PROKKA_00001 hypothetical protein
+MMARPGRVTSHQASVMYARPSANMRPQVGWGGGTPMPRKESPLSQMMILATRTVPSTKSG
+ERMLGRMWRRMMVRFRVPRLWAALTNSFSFRASTLPRTVRA*
+>PROKKA_00002 Glutathione transport system permease protein GsiC
+MGRYILKRLWHTVYVVVGISVIAFFFIHLSGDPVMLMLPADASHQEIEELRQQLGFNDPL
+YVQYWRFATKAVQGDFGESLYYHVPAMELILERLPASLELALAAMAIALVVAIPLGILSA
+VKRGSFIDLGSMLGALFGLSMPHFWLGIMLILLFSVKLGWLPTSGRGGWEHLIMPSLALG
+MSLMAMFARLTRSVMLEVLGQDYVRTARAKGLKERLVIGKHALKNALIPLVTVAGMQFGF
+LIGGTVIIETVFAWPGVGRLVVQAIFNRDYPLVQATVLVLAVLFVLVNLLVDLLYVYLDP
+QISYLEEK*
+>PROKKA_00003 Heme-binding protein A precursor
+MKKFKRLCLALGVAALGLAILAGPALAKKDVLVVIQEAEPVGLDLMTSSIQTTMSVCYNI
+HDTLFAPQEDASVKPRLAESWEKVDDLTWKIHLRRDATFHNGEPVNAQAVKFSFERSFKP
+SIKNPHKGKLSAFKEVKVLDDYTLLISTKEPYAPGLYILGYYLPIVPPGYIKKVGDAKYN
+TNPIGCGPYKLEKWVRGEEIVLTAYDKYYGPKPAFKKVIFKGVPEEASRIAALLTGEADV
+ISGVSIHQRKRILASGKAYLTNQMGVMPYLGLNTYKPPFNDVRVRQAMNYAVNRELINKA
+LFGGKAILCAGPISPRTFGHDPNLKPYPYDPAKAKKLLAEAGYPNGFQTRLAYPTYMSQI
+QEQAEAIAADLAKVGVKVRLEPYERAVMWQRYKARKHAMYIYWWDDAPEPDRYMYSLFNS
+KVRDYYYKNPEVDKLLDLGRTILDRKKRAEVYHKIDRLLYNDAPWVYLYVIPEVFAVSNQ
+VAYQGRRDGFLDMRTAKPK*
+>PROKKA_00004 Oligopeptide transport ATP-binding protein OppF
+VAEVLRVKELVKHFPVRQGFFGRRQGVVHAVDGVSFTLEENQTLGLVGESGCGKSTIAFC
+LLRLIDPTAGEVWFQGRNLAAAGSEELRRLRRDIQIVFQDPFGSLNPRMTVAQIVEEPLL
+NHLELSAARRRELVAEGLSMVGLLPEHAQRFPHEFSGGQRQRICLARALVLRPKVIICDE
+PVSALDVSVQAQVLNLLSRLQRQLGLSYIFVSHDLAVIRYVSQRVAVMYLGRIVEQAGVK
+ELYARPMHPYTQALLSAVPVPNPRRRRRRIILEGDVPSPLDPPSGCHFHPRCGRAMEICR
+HQAPELRPLADGHLVACHLYDEVRSAPGGTVEGG*
+>PROKKA_00005 Oligopeptide transport ATP-binding protein OppD
+VARAVDGVDLTVGRGEILGLVGESGCGKSALALSVLRLLPMPPAFFAGGQIRFKGRDLLK
+MDPEELRRLRGNQISMIFQEPMTALNPVFTIGNQLGEVFRVHQGLARREARRRAVEMLEM
+VGVPAPARRVREYPYQLSGGMRQRVMIAMALACRPALLLADEPTTALDVTIQAQILELIL
+ELRDELGTAVVLITHDLGVVAETTERLAVMYTGRIVEQAPTVELFDHPLHPYTRGLLEAI
+PSAEAELADKELHEIRGVVPSLLDLPPGCNFAPRCHLADERCARQEPELVEVRPGHRVAC
+WRVDRG*
+>PROKKA_00006 Primosomal protein N'
+MTLMVDVALAAPLWQPLTYAVPAELAPLVKPLSRLLVPLRGGARLGFALGEPLAAGGGQD
+ALKPVLDVLEDGKGPQVWPPELLPFFQRAAAYYHVPLGQVLAWCLPAGMGSARPAKALAP
+KTQQVAVVSWRRGEDSRLPRPESQAARILRRLKARGPLPLPELREEFPRAAALCRDLEKR
+GWVTISHRPLVKDLLGRPLLPEPEPEHYTPDQQRALDELLPAVHSGGFKSFLLHGVTGSG
+KTELYMACVKAALEAGRTALLLTPEIGLCLRLEGLLRQRFGAGQVAVLHSGLSPAARRGQ
+WLAIARGRARVVVGARSAVFAPLREPGVICVDEEQDEAYKQEDRFRYHARDLALLRGREQ
+DCPVVLGTATPAVTTYHRAQEGNTVCLRLPRRVREAPLPRMELVDLRREGRLVGGFLSRR
+LLAALEQTLEAGEQAILFLNRRGFAPAYLCTACGQTVGCPACAVSLTLHQGSDRLVCHVC
+GHQRPRPRTCPACGAGEEKLRPLGLGTEAVAQKLGELLPGARIARLDRDTAGDPRRLGEL
+LRAIAERRVEVVVGTQMITKGHDFPGIGLVGVLSADQALALPDFRAGERAYGLLTQVAGR
+AGRQGGKSRVIVQAYDPDHHALRAALAQRPDEFYQTELAERRALGYPPFMRLVALRLEAV
+DDRRCQRAAQALAAGLEEARRRLEPGARVLGPAPAALPRAKARHRWMILLKAPTAAAAGR
+TLRLGLHRSPPLPAGVRLLVDVDPVSLI*
+>PROKKA_00007 HTH-type transcriptional regulator IscR
+LALHTMAYLAAHPGRLISNRVIARDLGVSAAHLSKVLQRLARAGLLESLRGPTGGFRLGR
+PAGEISLMEVYEAIDGKFQPSSCLLGRPVCRGGKCVLGELGRNLERQTREYLLNTKLSEF
+EDFMCFEEGN*
+>PROKKA_00008 Anaerobic sulfite reductase subunit C
+MPLGKGRGGALPWDPRAEAALGRVPFFVRSLVRRKVEERVAEAGGRRVGLEDFQEAEAAF
+RAVRAGKSQKELEAMLPAENRPGVEMVVVQACRSRLSNCPNPLIDTQKWLERVQAWVEEL
+DLSERLRRRVADDKILFHHKLKIAIAGCPNGCSRPQIADLALVGMTRPRLVEPEVCTACG
+ACAEACPDGAVSQDDGPPEFHRELCQGCLSCSRACPVGGIELDPPGVRVLMAGKLGRHPH
+LARPVMEATGPEPVLAYWTRELEEYLASAPPGRRFSAWWLEQHPAG*
+>PROKKA_00009 hypothetical protein
+MPIPGRLLTTAMAVMPHTDVDQALASALSLDIPFWPQLPRVNYYEDMYVQASEHFPGMVV
+DHKERTLVFSMDKFMVELEETLAHLEEPEYFDISPEYSVVYHRFLELELADRPAIRGQLE
+GPISFGLNVKDQDDRPILFDDTVRPFLLEVMARRVNVQLTRLKARNPNAFMFVDEPGLQF
+IFSGLSGYSDRKAKEDLDQFFAAIERPRGIHLCGNPDWDFLLNLDLDILSLDVYSNGEVF
+SSYARSIKRFLDRGGVLAWGLVPTNFEPFSAEDHVSLKARLKEIWSALESKGVDRELMLE
+RSLLSPATCCLVNPDGEKTVDKAFALVRALSAELRDEYGLDG*
+>PROKKA_00010 diguanylate cyclase
+VEVDISLFSNQNQFVILRVGEQAYALPAAQVREMQVLPEVTEVPRAPAHLRGIISPRGEV
+LPLFDLRRRLGMRSLAEEADELLKILEAREQEHKQWLEELESCIREEREFTLPTDPEKCA
+FGQWYQNFTTEDLALASVLERLAAPHRRVHEVAGAALEALEKEGQAAAQEVIDRARRIIL
+PKLLELFAELKRLIRETHQEIAVILESGRHTLALAVDNVDSVELLQPKDLQNLERFGPVD
+GSQDLLESVGRRANGETVYILKTAEFFQAATDLTF*
+>PROKKA_00011 putative phospholipid ABC transporter permease protein MlaE
+MAHGQEPAYEMKSEPAGNGELRVDLSGRLDMNALEGAVDQFGRLLKEQRPRRVELAVGGI
+DYLDSGGALALTLMEEAARKAGTKFQLVQAGPEVRGMLALVDMDKIRRRPLRPAERGLGF
+VEQVGQASLEVWRDFVELVTFLGDFLIALGRSLRRPRLVRWQETFFYMEQVGVNGLPIVG
+LISFLLGLIIAFMSSLQLKTFGADAYVAALVSVAMVRELGPIMTAILVAGRSGSAFAAEI
+GTMRVNEEVDALEVMGFDPTDFLAMPKVLAALAVVPMLTIYSCVAGILGGMVVGIWGLGL
+TPYTYLHHTIDSLSAYGIVTALIKSVAFALIIAGIGCQRGFMVRGGAQAVGSATTSAVVT
+AMFLIIVADSAFAILFYYVF*
+>PROKKA_00012 Arginine transport ATP-binding protein ArtM
+MSAEDPIIEVRGLKAQFGEQVILRGVSFAVARGEVVVVAGGSGCGKSTLLKHMLGLYQPA
+AGSVLIDGVDIAQADAAQLEWVRRRIGVLFQSGALLGSLTLLENVMLPLVGFTPLSRRGA
+ELVARLKLSLVGLSGYENHLPSELSGGMQKRAGLARAMALDPQVLFFDEPSAGLDPVTSA
+ELDLLIKRINRNLGTTMVIVSHELASIFEIAHRVILLDKQAKGIIAMGPPQELSGVPRLF
+PGGIL*
+>PROKKA_00013 hypothetical protein
+MTAPRWSATRASASSQSSRAPPGRERCSCRRPSSRRRRAGSSSRARPREPPLMAALRRAS
+WGSSPRRVSSSTTSSGSRGEKFTRRQRLTRVGSTSRGSCTVSTRMLLGGGSSRVLSRAPE
+LARLSRPASRITTMRQPPPKGAKLSVRITSRTCSTLIWAEGESEGGSTTKKSSWLPAARR
+RQGPQAPQGVSPGSWQLAAANRARAVVVRPTPRGPTKR*
+>PROKKA_00014 Thymidylate kinase
+MKRAPFITLEGGEGCGKSTHASLLAQRIRELGLPALLTHEPGATELGGALRRLLADPAGP
+DPCPQAELLLYLADRAQHLEQVIRPALAAGEAVVCDRFADSTQVYQGLARGLGADRVREL
+NRWLCGDTWPDLTIVLDLDPALGLARARHRQGKQGLDRLEQAGGEFHRLVREGFLELARQ
+EPERVRLIEAAGSRPEVARRIWEVARPLLESWRKTREA*
+>PROKKA_00015 Glycosyl hydrolases family 43
+VQFVQSSYPLAGLWRPGQETPPASGDTSGSGGVSGGAGFARMLDGKLRQGEPADLSTGAT
+RQTGGPVRYSPHSPLLVGASIGAAPGLFTAPVVWSDPTPAAPKGAYRMHSANPRSTFPLR
+TVPPPPAPPPSSEHENEDVGLPSAISTYHGSRFRAEVQVGERQEVNADVEQFHFPHLVQK
+NGLTYAYFIDHSHGSENDVGLAVSKDGVNFQYQGKVLTKGPEGFDAQMASFPAVQYDGET
+NTWYMLYEAKADHDDLNTVCLATSPDGRNWTKHGPVIEPGDAGEISAVDVGTPTMFKEGG
+QWHVYFHTLAKDGRVRIGYAHGENLQDLTVNQGPLLDVDPQGIEGGTVGARSNVVKVGDF
+YYMAYEVCSPNTDFHRSQWGTNLARASSPGGPWVKMSGRPLLVNDRPGMGMDGPELSLQD
+GKLYLYYRHGANATARVELSGLGDSSKMYLAHQSSPGVPV*
+>PROKKA_00016 hypothetical protein
+MSKLFGILAGLIGIFLLVASVISFGHLVEDAWVRGGMLASLLFALLLLLGSAAFLLTAVL
+LFRMRSHYLPRLYELEELEGLEEPPPKTKDSGESNGPRLA*
+>PROKKA_00017 Flagellar hook protein FlgE
+MEARTLFNGALGVKAHVRGLESVSDNIANVNTYGYKATRAQFSDLLYQEMAGGAGFPQQV
+GNGALTAVENMMMQAPLEPTENVLDMAINGRGFFTVKHPDRNEGNRYTRAGQFYLDKDYF
+LVNSEGYRVQGFAVDADGNVNVNQVQDIQIDNQIQDATATTSVDLAVNLDASDTTEFRQA
+VAIDPTDSGTYNFRMGFQVVDEDGDTQDIAVFYQKLESYTGDAPAGSQSVWKAATFHNDS
+GTLTADPSYPDNTFFLHFDTNGQLVGVTTGTPATGDSYTSNAEVSSTSASVSDRLGETFA
+YTGAGNTQTLRSTATITFSGTTTAGDTVTIGGTNYTFAALSPSDAAAWLADQINANSAGS
+YYAQDDASGTVTLYAKDGTAAAEVSASSVVISTDDTMSLTELVNTVDSGRKATGSLFVNI
+AGLTAGSSTVTVAGHTFTYGPAQDFTTLSELTTLINDLSEVDATSSGHNIYITAASVGTS
+GNSLGLATNDAANVAVSASTLLNGLDDSDATNIDASATTGSGGGQALKLDRTDVGASATI
+DVATTNTLGSNLGLDFTGGNFTQNSTASDGNGTSNTTGEVPLTFTFTKSGSTLTQQVTLD
+YSPTDGDDSTMLAGDYETFYLKTDGRGTGYLKYLEIDDQGLITAHYTNGQGVPQAALALT
+TFIAPQELLREGDNLWRATAAAGVPTVAQAGDAQTAMGEVKSYALELSTVDLAQEFVNLI
+NYQRSFQANSKSIITGDEMLKTAINLKG*
+>PROKKA_00018 Metallo-beta-lactamase L1 precursor
+MDHAALPQTLAPGLYRLGSYHLACFLVETPDAALLFETGMSLVAPLILAQLDELGVPREK
+IRWIVHSHAHSDHSTGQAALLEALPRAELLLSPTSRRHLAKPSTAEQFAKEDDSTRRALE
+RIGALPPGSLPDPLPLLPARHRTVEPGDTLDLGGLTVELRSAAGHVPGGLLAWLPELGAF
+LASDSAGFHMAARPNYPLYFTGYREYLRTLEEIRRTNPELLCLGHQGWFRGGEARRYLEA
+LKAHLAFEHATIWEAHRRGEDEESQARRLVERYYHDELAIYPRDILWYCCRLLVRRSLEA
+GA*
+>PROKKA_00019 Acyl-CoA dehydrogenase
+VNYEPCVKHKVVRNTVRDFAEAELRPIAHEVDQNSRFPWEVVEKMRGLQYFGLQAPRELG
+GAGLDSISYAIAIEELSRVCAGIGLCVTVHNSVALYPLLKFGSPEQIERLALDLISGRRI
+GAFCLTEAGAGSDAGAVETLALPCDEGYLINGTKIFVTNGGVCGLALIFAKTDLDHPRGA
+PSVLMVEKERSGFAVGEIEDLSGMRCNPVSSLFLEDCLVPPENLLGRRGDGLRIGLSALD
+TGRLGIAAQALGIAQGAFEAAVRYAKERQQFGKPIARFQTIQNYLADMATKIDAARMLLY
+RACAAKDQGQPFSAEAAKAKLFCSATAREVCNLAVQIHGGYGYSKEYEVERYYRDAKVTE
+LYEGTSEVQRMVIARAILSAPA*
+>PROKKA_00020 Acryloyl-CoA reductase electron transfer subunit gamma
+MKLVVFLKQVPGVTEIPWDPASGHLRREKAPGMMNPACRHALEAALILKEQHGGELTAIS
+MGPPAAEEILREALALGADRAVLLSDPRLAGADTPATSYTLSLAVRAVCPDCDLLLLGNQ
+TSDSETGQVGPHLAEELDLPSAINVEELELDGEVLRVKRLCDNFLETLEMDLPALVTINT
+QGHPPRQVPLGGVEDAFSRGEFLVLNAEDLKADLARVGMTGSAGRIVKVYPAGGERKGEL
+IKGAPKRCVLELLERHGDLLGGYLRKDLGGGR*
+>PROKKA_00021 Acryloyl-CoA reductase electron transfer subunit beta
+MSRRQQENGAVWVFGDYRNYFQNRVTLQLLARARDLASHLDTKVAVVVMGYRVGRWVREY
+VAHGADVVYVLDHPSLKYYLVQTYTRLMERLAGEHQPQIILVGATGFGKELAARLASRLG
+TGLTADCVDLTVDDQGRFIQTAPSFGGNLLAQIMIPQARPQMATVRPGTFQELPHDADRR
+GEIIKLPLPDDLPPEKARLIHSRRIKPRRRKLEKARVVICGGRGMGSKKKFKNLYALARL
+LGAQVGATRPVVYQGWAPEDALVGQAGRDVHPEVLFSFGVSGAIQHTAGIHDAQFIVAVN
+KNPAAQMMKMADVAIAADANQVCLALIRELKARLEKKK*
+>PROKKA_00022 Isopentenyl-diphosphate Delta-isomerase
+VNYTDPQELLPVVDAQDRVIGTMTRQEIHAKGLLHRAAHVLLFDPAGRLYLQKRSAAKDT
+YPGKWTSSASGHVDPAESYAQCAARELAEELGLEAELRPLGRLPAGPRTENEFVEIFTGV
+SAEPPRPNPQEIETGRFFTPAQALKLAADPTRACPSLGAVLELWQELEGD*
+>PROKKA_00023 hypothetical protein
+MESEVLQRVAEMLRSPGAVARNRNLLEFESEAGQRAWRCYRLFLSLLAELERAAQSPEVR
+VSAQETEGGLQLVLVDPRVSYRRSCLVPPELVELFLDKLTALGLLGGEKT*
+>PROKKA_00024 4-chlorobenzoyl coenzyme A dehalogenase-2
+VSRPRYVRTQRHGPVTVVVMDNPATMNAMDQDMGPRLVGALESLAADRSVRAVVLTGAGG
+RFSAGGNLTRAEEFLEENPGRGAAPVFAQYTIWVHRLLAVLTRLPQPVVAAVERAASGGG
+LGWLLACDLVVLAEDARLSTGFLAIGLAPAAGVSWHLPRLVGLPRAAELLMLGRTLGADR
+ALELGLADQLTPPGGTLEAALELAGELARGPAQALAATKQLLGGAARRGLFPQAEAERRA
+VLHTADQEEFARRLERFRQRRRRS*
+>PROKKA_00025 hypothetical protein
+MPMDWTPPPRGGGREPDINQVVQNLKNRLPVFKKARGLWLAVAVVLAIILGASSYYTCS*
+>PROKKA_00026 hypothetical protein
+VSRDWFPAKVRFMSGGRAQQTPLAIRVEGRWLEVRLLGEELVAPESGLAYVRRYRLEDRR
+GRRWELRQRQEGWFCRELH*
+>PROKKA_00027 hypothetical protein
+MDQSKALAKYREFRPAWKSFLPYFLGVVIFTVGPRVNPQAPISPDLSHLIATCFLAFILI
+TRFSNLYELADGRLGWRRSFPRALERQAPVEQITRIDLRRGIFHRLAGVAHVHVYLENQQ
+EPYLKLFGVSEPEELRRLLLDLGASDQRVTGAWRK*
+>PROKKA_00028 hypothetical protein
+MALLVSFFGKGRRGACLLGLLGLLLLAPPAVAAGAGYVVAPVNKGADLRLLPSEAWPPPE
+GSRADILIKLAYLRGIMDALQYLELAPRSAERVLNAYQGLSLQDLAARIDAFYLTDPRRR
+DLPPAVVLFRLLAPAGKDAPAVKGPARPGGQGGRSGK*
+>PROKKA_00029 hypothetical protein
+MQRSSGSITQLARLVESLAELLRLHYGPDGLPAAQEEDLCSQEVEGRRLGELLAELWPDS
+GPWRGPCLGQGAIRETERLLRYRLQQAEAQNRALATRLERVRRQVAAQRRTLLEQLRAAR
+LQVEQGQARLEALSAELGGLRAELERRRERARRRRRYLEGVVPRGMNRFADAGGRILDQA
+TLRRATRELRELQALVVRTKDACARLEHRWARARLELARARSHEAGLRAELARLEPYWQA
+KTHRLARAKVVLAARQEELGPLERNLHRLRVMGLAHAEVVSRGRAALEPLLAPLASGESP
+DPVESLEESLTQAGEQARRGRRLTALMERLGRRLERRLEAIGPVLKEQRRLNKEITRLEN
+ELPGLLEPLLAGDGADPRNRQEAGARFSLLIARLEDLIPQARATQEQLDELRQALTIGLS
+RGKAWQAAWRRAGKAERAALHQAQALVEEVRLAARQAARQAEHLRRRAEPAVKALSPLRS
+QDLLPSLAALAQGVSRGQLKARQLEARAAELEGRIPRPYFGNLSKPPVALKPVSAGLRRL
+SGKQVELERLAALERAARRWQGLLDGPLVEEIRRPVEQVALRLARSLTLLERQKNLLASR
+HQKQGRELSTLKAELDQRRRREELARRRLEQVRDRNRRQQRTIRNYETELKQAQTRAALA
+QRLEDELARLGEHAQTLARRLERSDKLAAALKRKSLERHRLYRRSQYAVEWLDYWRERAL
+EQEKLLSSARAELELARREYQQARSLLASAVSERDQALKELATERAARARQALDLLGGKA
+LSVELAASRSEAGRWAKLAQDMALALAASGEHHRQETADLRAQVDQLSAEAAMLKRQLER
+IAAMVEVQVPGLEELADLPPAPSWRRPVALRLVPLGPKQVAQALDRLSAARRRLQNLGRG
+TLGHWALIAALTCGLVLTPPGTPSKATRADAPLKPPRPVLRHLAQGSPLTPIYQVPAQAR
+LLGDKVARGSLELNLLPLRGQPVAVPQSVKRRLKELAREAGLSPKVLLTSARALYAGQAA
+VDPSALEELAHTARQLARRHPLIFRELSRRGLPPAASAVAALAPEPEKAQHLFLDRLYRE
+YRSLGFSAEEALGALAANQRAFHRLTRQWTPPRRFIGKVQPVEAVEKMGLREFLQKITPY
+IQSKLKVFLRQRGMSYSGDLTLYAKNLAFDMYCAAKKFQVPVTLLLAIAHQETWYANVLG
+DANRSASPFQIYEPTRELIIKSMAEAGFVPPPKRIKLQRHLTMATFMASFHLRELMQRAY
+TPPRRGRQAVVNLDRVLQRYNGSSRYAAQVALRKRQLARFLRRQG*
+>PROKKA_00030 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase
+MIGKRIRLERVMDRGTRRTVLVPLVHGVGMGPIEGITDVLNTVDTISMGGANAVVLHKGI
+VAAGHRRGGADIGLVIHLSATCADGSQTLVTEVEEAVCLGADAVSLRIEVGGADEDESLA
+LLGAVSRVAADWGMPLLALMNPAPIPPAKMPKLLMRAARIGAELGADVVLVPYHKRFAEV
+VAATPVPVVAIGGVKKTPPKQMLEMARAAVDAGAYGVSVGRTVFQYEKPGNMIKAICQVV
+HRKATVKKAMEILAKKPIESTLYGGTVIW*
+>PROKKA_00031 MmgE/PrpD family protein
+LTTLETLGRFAAGLKADELPPRLGEAVNRCLIDLLGAACAGHGSGAARMVRAVAGPLFAA
+GPAWLWFSGRRLASPGAALANAAAASAWDLDDGHRAAAGHPGAAIIPACLAAAQETGASA
+RELEAALVLGYEVACRVAAARDLARLPTMASGRWVAYGVAAAAGRLHGLDAAGLAQAMAV
+AGVLSPDLAAAGYSRLMGNLVKEGIPWATLTGLVAVKLAAHGFSGPLDILDHPDYYQAPG
+ITAGLGGGQWAIEQVYFKPYACCRWCHAAIDALLALQDEQGLDADEIAEIQVHTFERALR
+LSNETGPATLEGAQYSLPFTLAVAAVEGAAGLLPLRPELLGREDLVELAGRVRLEVDPEL
+EAMFPERSPARVVAMTRSGRRHEHTVLDPLGDPANPLSTARLEEKFRALTAGLLPPSRQQ
+ALLVRIHALEPEGLPPLLEELGRPLQPEK*
+>PROKKA_00032 2,3-diketo-L-gulonate-binding periplasmic protein YiaO precursor
+VARLSEDERRIRRMVGSRIRELRQALDLRATELASRAGISQSQLSKLENGKAAISIPVLT
+SLCRVLDRPLSYLFQKEEEIPRVLGTMTTVSGPENRGLEWFAAEVNRRSGGRMSIIPLWA
+TMLGSAPDQVAMLRQGVIDLFIEELIFYQHIAPAVKLISLPYVFADDAHLLSFLESPFFQ
+ERVHGPLTKSGIRILNRRWNWRRGLERVLVARQPVTRPEEVKGLKVRIFDSPALARFWEE
+LGARPVVVPWPRVREAWEAGEFDLLPTHRSHLYPLGFCRQGRFVTLLGDVPPALAVTVNE
+QKYLSLPPAVQAALEESCDAAGGFFSIEIRRAEVDNQAANLAEYGAVYLKVDLEPWRRAA
+GRVVERMAREGAVDLDAWQAVQELRPAGEGA*
+>PROKKA_00033 Lysine 6-dehydrogenase
+MSNRDIHNATGDSVKMNALVLGAGLQGKAVIHDLSRSELVDRILVADLDLAAAQRFLDKG
+GYHKVRAVQADALDPAVLRRLISENRSDIVVCMLPAHLSGRIAEVCVECGVPFVNTSYAQ
+WLGELDQRARDKGVILLPEMGFDPGIDLIVGRMALDELDQVEGFYSYGGGLPDPAACDNP
+LKYKITWTFDGVLKAYCRPARLLRQGRPVEIPGDEIFQEENIHFIEVPELGRLEAYPNGD
+ATRFVEVFGLGPELKEMGRFATRWPGHSAFWRIMAKLGFLGDQPVELGEGVSVSPREFLV
+KLLEPRLQFRENERDVVVLRVKVWGRRGGRKRTVTYDLVDYRDLATGLFAMNRTVGFAAS
+IGAQMVLKGEITGAGVLSPVKVVDGQRFLDELAARGIKVQRRLEEE*
+>PROKKA_00034 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00035 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00036 D-3-phosphoglycerate dehydrogenase
+MFKVMIRDSMSPVAREILTATGKIEVVTDNDKAANAPEVLAEMIGEFDGLAIRSGTQVTR
+AVMEKAGRLKIIGRAGIGVDNIDLEAATRQGIVVMNAPGGNTVTTAEHTVSMMMALARNI
+PQATASLREGAWDKKKLIGVEIAGKTLGIIGLGHVGRIVADRARGLKMRVIAADPYVSCD
+AAARINVRLVSLDELFSASDFISLHVPRLKETVNMINADTLSRMKPGVRIINCSRGDVVN
+VDDLYRALESGRVAGAAIDVFPKEPPDASLPLLKHPRVVLSPHIGASTGEAQVKVARMIA
+EQMAACLIDGVITNAVNFPSVSMEEMARVV*
+>PROKKA_00037 Ferredoxin
+MNDPIYQKLATVLDTLPNGFPATEDGKEIRLLKKIFSPEEAELFCDLKLTFETAEQIANR
+TARPVEELKARLSVMQEKGQIFGIDMGGVGIYKMLPWAFGIYEFQLPHMDRELAELCEQY
+GKTYGKQFFANKPQLMQVVPIESEIKAEHEALPYERVSTIIENSRSFMYFDCICKKEKGL
+MDEPCDKPVQVCTAFAPIPGVFDDHPYGKTMTKEEAYQLLNKAEEAGLVHLTWNVKSGHF
+FICNCCGCCCGVLRGINELGIDASKVINSYYYAQIDAEACVACGTCADERCQVNAIMEGD
+DAYTVIAEKCIGCGLCITTCPGDAISLVRKPAAQIETPPDDEMDWYEKRAQLRGVDISDY
+K*
+>PROKKA_00038 Nif-specific regulatory protein
+MELTNDEREFFALVNRASLLNPFSDERNDVDLKLAGLPSAAPGTGRVKKAIQSVNERIRQ
+LETDGRADISQYTGRDRELVEKAFLFELFYRFRKQFDELIESQIASDDVPARIPFYNDAF
+SAMQKRGFTEEDFRRYFALAFQIRRAFYFIGRSLVGNSASMKSLRLNLWNNVFTHNMDLY
+DRYLWNRMEDYSTLILGETGTGKGAAALAIGRSGFIPLKKKSFEESFTRSFISLNLSQFP
+ETLIESALFGHKKGAFTGAIENYQGIFEQCSPYGAILLDEIGEVSKPIQIKLLQVIQDRV
+FTPVGSQTRSRFNGRVIAATNRPLETLRGKGFFRDDFYYRLCSDIIVVPPLRQRVQEDPT
+ELDVLLDFTINRLVGRSSPELVQIVREVIDRHLGNDYPWPGNVRELEQCVRRVLLKGIYT
+GDAAVADIDLCRSLTTGIEQGNIDANSLTSGYCYLLYQRHRTFEEVARRTGLDRRTVKKY
+IQDWTSSHSTDNPPETDIPG*
+>PROKKA_00039 hypothetical protein
+MKIQQIIIREFEEMMAELKEVLAKMTCPLLGEDWLPM*
+>PROKKA_00040 Formate hydrogenlyase transcriptional activator
+MAVDKNEFFRQATIRICGSLDIETALERCFHYLEQMLPVDEIGLYLYDPGLNVFQRIAGV
+KSHGKNEFSPVSPLPEASKEKWSAIWADMGDITIINRVEERPEIQEVIEMYGLEHDISLM
+SMRLELEGKRVGLLLLRTRGRDRYEEKHARLMLLLHEPFAIAMTNALQHQELIRLKDILT
+DDNRYLRRQIRDLSISEIVGADLGLRHVMEMVQQVTQLDSPVLLLGETGVGKGVVAHAIH
+DASPRKNAPFVSVNCGAIPESLFDSELFGHEKGAFTGAIAQKKGRFERADKGTIFLDEIG
+ELPPHAQVRLLHVFQEKIIERVGGTTPISVDVRIISATHRNLEEMIRSGKFREDLWFRLN
+VFPIHIPPLRQRKEDIPALVHHFIEKKTIDLKMQEQPRLSPGAMDQLMAYDWPGNVRELE
+NIVERALIQFKGGMLRFDGLIFSPIASSRGGGHETTDRFLSIDEVNAIHIRRALKVTNGK
+INGPGGAAELLGINPNTLRKRMNKLNIPYKKKEIGQGVD*
+>PROKKA_00041 hypothetical protein
+MRFKTLKYILVPVLAIGLSGCASTLTLLSPPSSRLVQGKNTAGAFNSYEYQYAVRGNKIY
+IKRTPLCDEVKHVMRVEQKREIGYGPALLELPLFGLGLVDIANAHAISVNSKKVTPLADY
+NTGKLMACGPLQPAANEKVIIENKNLNLYRMVRTDKNGVVNLDKVLSGIGNNVNLSVRLA
+NNHNVAFSCMYIANR*
+>PROKKA_00042 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00043 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00044 Pimeloyl-[acyl-carrier protein] methyl ester esterase
+MWQEHIAGRKIGLETGPRPFDPHKPCLLMVHGSGGRGETFRPQLSGLAPYLNPAAIDLPG
+HGNTPGPGRDQVAHYADWLAEFIRRGPLRPALLGHSLGGAIVMQLALDHPDLAPALVLVG
+TGSRLRVLPAILDGLLSDFDATLDLVLKYAYAPGADPRWVQAGREIMSQPGPRVVHDDFA
+ACDRYDITDRLGEITAPTLLIYGDQDQLTPPKYGRFLAERLPDARLEIVAGAGHMVNLER
+HAEVNRLIHPFISAFSPPASS*
+>PROKKA_00045 Secreted effector protein pipB2
+MSETPRRPRDSRYMWRGIRPSEEELKTILEDHAQWLERLRSWEYSWREFIEEIPPPHDLS
+GADLLEADLSDADLTWAKLSNAILFEADLSNADLREADLSNAKLWWADLSDADLTWAKLS
+NAKLLAADLSNAELWWADLSNAKLIKADLSNADLTGADLSNCDVTGVRYHGPWLGIPFIQ
+IRKPNKLTCRGIRADTCYGSPRFRRDVMDQDFLEEMRETTGGRWLYRLWWLTSNCGRSFI
+RWAFFSLSLAVAFACVFCSSLGPECFDLHRAEGSRWVAEVAGRYLEVDPAYLGTTAASRG
+LPGDFWTMLYYSLVTFTTLGFGDVVPLTPWAAFWVTIEVVTGYIMLGGLVSILASKMARR
+AG*
+>PROKKA_00046 2,6-dihydropseudooxynicotine hydrolase
+MRARLFKWAGVFFLSLAMAGPAWAASRATPHRRPVLKLHFADVSYDYELKRAMSYAVSGG
+ADINECLTAARAITAGDGESWYRGWHRMARRLDQMADQALKAGHRQTARQFWLRASNYYR
+AAEFFLHGNPKDPRILSAWGASRRCFRQAARLMDHPVEVIAIPYEGHKLPGYLVKPDASL
+KPRKTLLLQTGFDGTGEELYMEVAWYAIQRGYNVLIFEGPGQGGALREQHLYFRPDWEKV
+VTPVVDYALTRPEVDPKRLALMGLSMGGYLTPRAAAFEHRLAALVADPGDFDMMVGHRPT
+PAEWAGMKKYPKQANQALRAKMKHDTGFRWLVNNGMFTTGRKTPLAFLEFFSRFELTPKI
+AAQIKCPTLVVVGAGDHFASPKWQRLLYDNLTAPKTLLRFGPDNPARQHCQVGGLLWGNA
+KIFDWLDQVLR*
+>PROKKA_00047 Methionine--tRNA ligase
+MQVVQAILSKVHEAGDIYFAKYGGHYCVGCERFLTEHEMIDGKCPDHGTEPVYQEEENYF
+FRMSDYTQPLKEYIRANPDFIRPERYKNEVLAILDQGLEDLCISRPKTRLTWGIELPFDQ
+NFVTYVWFDALINYLSGLDWPDGELLERFWTGPKADPQHLIAKDILKPHGIYWPTMLMAL
+AKAEGRPLDHYLYRHLNVHGYWQVGEGKMSKSRGNVVKPLDLAGIYGVDPFRYFLLREMT
+FGLDASFSEDLLVERYNADLANDLGNLFSRVLNMLSRYRDGLLPELHPQELTEADREMKG
+ALAASLGPGAEHDFQAQVREFRFHTALADLWSQVRRANKYIVAREPWVMAKDPDRAAELD
+NVLYILVQLLASVTHLAWPVMPATAEKMAAMLGLELVVPVDWQRLFALELMTPGAKAEKP
+QALFPRVQTDKVKAKAARKEAKQAQQQPAAKGGGKQKAKPQDKAGLITIDEFAKVELRLG
+RVLEAGAIKGADKLLKLKVDLGEPEPRQIVAGIARHYRPEELVGRQVVVVANLKPAKLRG
+EISQGMVLACVAEGRVRLVAPEEELPPGSVVR*
+>PROKKA_00048 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00049 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00050 Protein translocase subunit SecY
+MFLAGALIVFRIGIHVPVPGVDPTAYAHLFNQNAGGILGIFNVFSGGALEQMSIFALGVM
+PYISASIIIQMLTSVVPSLEALKKEGQAGQRKITRYTRYSTVALALFQSLGAAFALQSQG
+VALTAGPGFIVTATVSLVTGTMFLMWLGEQVTERGLGNGISMIIFAGIVAGLPSAIASTL
+ELVRNGELSSIVAILIFVGVLLITAFVVFVESGQRRITVNYAKRQQGRRMYAAQTSHLPL
+KLNMSGVIPPIFASSIILFPVTLAGWLGQSSGFGWLNTLQLWLSPGQPLYVALFAVLIIF
+FTFFYTALTFNSDETADNLKKSGAFIPGIRPGKQTAGYIDTVLTKLTLWGALYLTAVCLL
+PEFLIAYAHVSFNFGGTSLLIVVVVAMDFMGQLQAHMMTHQYEGLLKRARMRGLQR*
+>PROKKA_00051 50S ribosomal protein L36
+MKVRASVKKICRNCKIIRRRGAVRVICSDPRHKQRQG*
+>PROKKA_00052 30S ribosomal protein S13
+MARIAGINIPPHKHTVIGLTAIYGIGRTRAAEICATAGVDPTRKVKDLSESELEAIRQAL
+TAYKLEGDLRRELNMNLKRLMDLGTFRGIRHRRGLPVRGQRTRTNARTRKGRVRRSAKR*
+>PROKKA_00053 30S ribosomal protein S11
+MAKPAAKARKRIKQQVVDGIVHVHASFNNTIITITDRKGNTLSWATAGGSGFRGSRKSTP
+FAAQVAAERAGAVAQEYGVKNLEVEIKGPGPGRESAVRALNNLGFRVLSISDVTPIPHNG
+CRPPKKRRV*
+>PROKKA_00054 30S ribosomal protein S4
+MARYIGPKCKLARREGTDLFLKSPIKALDQKCKIDRIPGQHGQATRRGRMSDYGLQLREK
+QKLRRMYGVLERQFRRYYKEAARRKGATGALLLQLLESRLDNVIYRMGFASTRAEARQLV
+SHKGVTVNGQLVNIPSFEVKGGDEVALTERARKQNRVEMALEISRQIERPAWVEVDEKAC
+KGTFKAMPEREELLPDINENLVVELYSK*
+>PROKKA_00055 DNA-directed RNA polymerase subunit alpha
+MEISVSEFLKPRIAGLTELGENRTRIVLEPLERGFGYTLGNSLRRVLLSSMPGAAVVEAE
+IDGVLHEYTAIDGVQEDVVEILLNLKLLAIRMHAREEATLTLNATGAGVVTAGDIQVDHD
+VEIVNKDLVIAHLAKNGKLSVRLKVMRGRGYMPVVKRYADESQGRKIGKLKLDATFTPIR
+RVAYYVEAARVEQRTDLDKLILDIETNGTIGAEEALRRAAGILTDQLSVFADLSSVSSHT
+PTESRSVKPILLKPVEELELTVRSSNALKAERIRFVGDLVQKSEDELLKTPNLGRKSLTE
+IKDVLARHELALGMKLEDWPPAALAERRAS*
+>PROKKA_00056 50S ribosomal protein L17
+MRHRNSGRALSRTSSHRAALMRNMSKSLIEHEQIRTTVPKAKELRRVVEPLITLAKSDSV
+ANRRLAFSRLRDDAIVAKLFTDLGPRYRERPGGYLRILKAGFRPGDNAPVAIVQLVEEQE
+TTSAAT*
+>PROKKA_00057 Dihydrolipoyl dehydrogenase
+MRKVRVAIVGAGTAGLTALAQVRRRTDEFVIVNDGPYGTTCARVGCMPSKALIHIANDFH
+RRRRFAEVGIAEGETLRIDLSKALAWVRAYRDSRTADSIKLTDPLGERNIPGRAELLSAH
+ELHIRRADGGEERIAADAVILAPGSTPVIPKSWDGFSARILTTDTLFEQRDLPRRMAVLG
+LGAIGLEMGQALARLGLQVHGFELRDRLGALTDPQLIAPAIEHFSREFDLHLGAPAELHP
+TGEYWRVETADAQVEVDAVLAAFGRRPRLDGLGLERLGVPLDAKGLPPVDPHTQRVADLP
+IFLAGDANARSPIMHEASDDGYIAAVNALDGPTPLNRRVPLVMAFTDPEMAIVGASFESL
+PAGSFDAAGYDFSRQGRAIAMRHAEGRLRVYAERNSGRLLGAEIFAPEGEHLAHLLALAL
+DRGLNVAELLRMPIYHPVLEEGLRSALRALARRVYDQPPQEFRRLPEGCPGMSSSSP*
+>PROKKA_00058 putative methyltransferase YcgJ
+MNPYERYLLPWLIDAVCALPAAARERAKIVPRARGEVLEIGIGTGHNLPYYAPRRVAGVT
+GIDPGVLRRRIMRRAHAAGIEVKLLSLSAESIPAEDASFDTLVSTFTLCSIPDVERALAE
+MRRVLKPTGRLLYLEHGTAPDPRVRRWQDRLTPWWKPLAGGCHLNRDIPRLITGAGFDIV
+EQHSEYIRGPRILSYVFRGEAQPIAVAGSK*
+>PROKKA_00059 hypothetical protein
+VVFVRLNLDAVTSNNKASDPDYFFFPASIFEKSHRHERMPKFILKDLSDYQQYRDNRELI
+SSFFENLPNKTLQLIAKPLCGSSAAKLIALVAFAVL*
+>PROKKA_00060 Sodium:sulfate symporter transmembrane region
+MLVVIYALTTILTAFIGNNAAAVLVFPLAYAAATKLGQPFLPYAIAIAMAASASFTTPIA
+YQTNLMVYGPGGYRLSDFVRFGLPLNLIVGVISVVVIAWLWMP*
+>PROKKA_00061 hypothetical protein
+METKTLSGNATPLTDEQWAGLARLGDLGNRLGALVDGPLSGPASAALDRIGALDGQYDLT
+ALAEKLVGTLSALDRAGLLDLLRDNAQFIADNLNTLTPMLDQWLAHIAELPADEFKADAK
+FALALLRKARLVTTFIQEKLAGELTTKAVEVTEFMQRNDTDEAVAEALVQLGRIYRSGLL
+ARLGDLADTVAGLEEGTDLDDQIDVLIKSSTAGGLGTFLIFLKSVSIAMQKVGQEPEPKL
+GGYIGMLHLLRDKEVQKGLRMLTVLPIYLEKRLEKSAS*
+>PROKKA_00062 Pyridine nucleotide-disulphide oxidoreductase
+MNAKPHVLVLGGNFAGLGSAQKIREFAGDAVDITVIDRKNYLLFVPNIPADVFENKDPAV
+GQRLDLPPVLVKDDIYFVQGEVTELDVDNRIVHYTPSERPGAAPQKIAYDYLVVALGNRL
+AFDKIEGFDEFGDSVSDIYLGNKLRKKLWEGGYKGGPIAVGSAMFHQGDGAKGLEPYPGG
+SIPDALAACEGPPVEVMLSAATYLKKTGQGGPEKITVFTPAELIAEDAGEKVVGQLLDIA
+SGMGFNYVNNAKDITRVTAEGVELANGQTIEAELKILFPDWVAHDFMRGLPISDSEGFVI
+TDLLMKNPKYPEVFAAGDAAAVTMPKLGAIGHQECDIVGRQIACAVGRMNEAAANTPLQP
+VVYCIGDMGDNQAFYIRSNSWFGGDTQVLKMGHTPFLLKMQYKNLFFRTQGKMPDWGLDF
+SELMAEKIAS*
+>PROKKA_00063 Citrate transporter
+VSWEAILTLVVLGAVVLGLAWPRMPPDLPLVGGLAILAVTGCAPIDKVFSGFSNPGLIAI
+AALYIVAAGLRHTGAVTAPARWLFGRSRRLWVAQLRIMLPTAVVSAFINNTPVVAALLPA
+VLDWGKRHRFAASRLAMPLSFAAILGGTCTLIGTSTTIIVNGLLTSTTHGPGMGFFTIGA
+VGLPVAIAGFIYILLFGRRLLPDRQGAMGEFTNPREYTVEMRVAAGSPLAGQTLEAAGLR
+HLPGLYLVEIERGGNLIPAPGPEELLEENDQLVFAGIVESVADLQKMRGLIPTTGQIFKL
+DTPRPDRRLIEAVIAPENPMVGRTVREGRFRSRYGAVVIAVARAGHRVTGKIGAITLIAG
+DTLLIEAPSEFQRRYRHSREFLLLRPLEESVQPHYERAWIAWLILAAVIGLVTARIVPLA
+PAAIFAAVAMVVTRCINLAAARRAIELQVILVIGAAFGIAAALVHTGAAALIAQPLLALA
+EGSPLGMLVVVYALTTILTAFIGNNAAAVLVFPLAYAAATKLGQPFLPYAIAIAMAASAS
+FTTPIAYQTNLMVYGPGGYRFSDFVRFGLPLNLIVGVISVVVIAWLWMP*
+>PROKKA_00064 UvrABC system protein A
+MDTIRIRGARTHNLKNINVELPRGSLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
+ARQFLALMEKPDVDSIEGLSPAIAIEQKASSHNPRSTIGTVTEIHDHLRLLFARAGTPRC
+PHHGLTLDAQTVSQMVDTVLADPSERRVMLLAPVVHGRKGQYQELLEDLKSRGFIRARID
+GTVYELDPLPRLDGHQPHDIEIVVDRFRIRSDMAARLAESFETALALADGSALIADIDKP
+HTSEMVFSARHACPQCGWSIPELEPRLFSFNNPAGACPQCAGLGRESYFDPGRIITQPSL
+SLAGGAIRGWDRRNPYYYRLIESLARHYEFDTEAPWSELSERTHRVLLYGSGEEEIDFTY
+VSARGQKQQRRHTFEGVLNILERRYHETGSQAVRDELVRYQSSRACTACNGTRLGEIARN
+VFIADTTLPDISNLAIDAVWRFFNDLDLPGRRGEIAKRIQHELHSRLGFLVDVGLGYLTL
+ARSTETLSGGEAQRIRLASQIGSGLTGVMYVLDEPSIGLHQRDNRRLIDTLTRLRDLDNS
+VIVVEHDEDAIRSADYLIDMGPGAGAHGGEVVATGTPEEVMNNPNSLTADYLSGRRTIPV
+PQARRHPQPGQAIIIRDAHGNNLKHIEVSIPLGLFTCVTGVSGSGKSTLVLDTLQAAGER
+LLNRARTEPAPHASIEGLDALDKVIAIDQSPIGRTPRSNPATYTGVFTAIRELFAQTPEA
+RARGYKPGRFSFNVRGGRCEACQGDGLVKVEMHFLPDIYVPCDLCHGSRYNRETLQIHYK
+GRTIEEVLNMTTEQAREFFANIPSIHHRLDTLVTVGLGYVKLGQSATTLSGGEAQRIKLA
+RELSRRDTGRVLYILDEPTTGLHFHDIRQLLAVLLRLRSHGNTVIVIEHNLDVIKTADWI
+IDLGPEGGHGGGQIIGEGSPEDIARLEHSHTGHYLMPLLKPHKLQKETTT*
+>PROKKA_00065 Aspartate-proton symporter
+MAGSGKLRKDAGIIGLLYFSLGGIIGSGWLFGPFDAAKAAGPWSIASWIIGAAVVMLLAL
+VFAELATMMPKSGALIHISHIGHGELIGRIWSWILFLSSVVTPPIEVMAVLTYLNNKIPY
+FVDPSTHVLSTIGFFAAIVLLGVVVVVNFFAIRFVLWINNIATWWKMFIPAISIIVLMSY
+SFHPGNFHLDLGSVNAAGMLTAVSTAGIVFSFLGFRLAINLGGETKNPGKYIPIAVIGSV
+LIATLIYVGLEVTTITSVRPSDFANGWPSLAFKGDAGPFAALAVTIGAVWWSWVLYADAI
+VSPFGTGLIYTTNTSRLGYAMAEVGSAPKKMQKLSRQGVPWISLLVTYVIACIFFFPFPS
+WHQLVGYVSDITVLSYGIGPVVLLIMRKRRPEEPRPFRLKGAKVIAPMAFIASNWVIFWT
+GCTTVTFLFGLLGSLFAVYAIWYYIIARKPSKEFGWKYAWWVFPYFIGMWLLSYIGPSTL
+GPAHVSLFNVQPLDILPLGWDMIAVAVFSLAVLYTATSSALPREEADRYFDELKKLNLPE
+EYSEGTESP*
+>PROKKA_00066 Cyclic di-GMP phosphodiesterase Gmr
+VQATDWLHQIAGPALVLNFADGTVIDINAAGRRLVGIEGQGLIGQDFCGFFVSSDADCCW
+PTLQRSINLQGGFRYEGLHLRTPGGAMRRVNVSAELLQSEQERAVLMLLQPGTASSPQAT
+DHEKELAQYATVGLYRLDAEGRLTHANHALARLLGYETVGQLLDSAAVQRSQWYVCDGVS
+EERVSDVNDAAIYRCKVQLRRAHGAAFRAVEAIREIRDVRGQLMSRIGTLREISDQSSSE
+QALAISEDKYRSLVEHSQDGVFVIRDGVYVFVSQVYSSMLDYAPEEMVGESFLRFFAPED
+RQKIVDVWHERQAGHWEQGAYEAHLLKKDGTRVLVSVRAGPIRFAGAMASTGTVRDITAY
+RDTQQQLSMAEQRYRDIFEHAVIGIYQTAPDGRLLAANPAMAQILGYDSVEELQEQVDDV
+GELFFDRIERDTLIEKLEAEGRMYGAELRLRHRKGTQLWVQDSARVVYDANGKLVCYEGM
+VADITARKIVEQALHRSEQLFRTLVEHTHVGVIMVREGVVTYANRALAHMLDYAESDLLE
+QPLASLFAPESRDCVERLEQELKTAVGSNIYESSMLAADGTRRVRANLSVASVIFEDNPV
+MIITAHDLTREKRAEARLRRLATHDPLTNLPNRVVLRERLAQVLKKTRETGNVDWAVLFL
+DLDAFKLVNDSLGHAAGDELLRQVAVRLRRAVRHDDLVCHHGGDEFVVLAFNITHEIDAV
+ELAEHIETAMAEPFRISDHEIYNQITIGIALGRQEYELPEEVLRDADSAVAAGKRLGKVC
+HVVFSSSMHVAAMERLELETTLRAGLTRGEFDCYYQPIFNVKNNRIESLEALLRWHHPEQ
+GVLRPHSFLQVAEESGAIVPLGWIGLRRALAACSQWQSLGLEREVSVAVNLSDAQFRLPQ
+LPEQLAHELEQAQLPFHLLHLEVTERVFLETPGLARRTLGRLHALGVKLYLDDFGTGYSA
+LSYLRELPFDALKDRS*
+>PROKKA_00067 Transketolase 1
+MPTRRELANAIRALAMDAVQKANSGHPGMPMGMADIAEVLYNDFLRHNPANPHWPGRDRF
+LLSNGHGCMLQYAALHLSGYDLSMDEIRNFRQLHSKTPGHPEYGHTPGVEVTTGPLGQGV
+ANGVGLALAEALLAAQFNRPGHKVIDHHTYVFCGDGCLMEGISHEAASIAGTLGLGKLVM
+VYDDNGISIDGEVKGWFHDDTQKRFEAYGWHTIGPIDGHDAEALKKAFAEAQIETKRPSL
+ILARTIIGFGAPDKQGTAEAHGSALGDAEVAKARKELGWKFPPFEIPESIYAGWDARARG
+EQAETEWHERFAAYAKAHPQLAKELKRRLAGELPADWATTVEQHIAHVARNGKAQATRKA
+SGATLAALAPTLPEIVGGSADLTPSNDTCWPEAKAVKPGTPEGNYLHWGVREFAMTAILN
+GMAVHGGFVPYGGTFLTFSDYARNAVRLAALAHYPTILVYTHDSIGLGEDGPTHQPVEHV
+ASLRAMPNLTLWRPADDVETAVAWRDAIERRDGPTMLVLTRQSVPHYERKAQQIEAIHRG
+GYILHEPQNAPRALIIATGSEVDLAMQAARVLTEENLPVRVVSMPCQELFLAQDVDWQEH
+VLPAQVTARVAVEAGVSMPWYRFVGIHGRVVAMERFGESAPAKQLFEEFSFTAERVAAAV
+REAVAAAAG*
+>PROKKA_00068 Glyceraldehyde-3-phosphate dehydrogenase
+MIKVGINGYGRIGRNVMRALYESGRRDQLQVVAINDLGDAQTNAHLTRYDSVHGRFPGDV
+QVEQGHLVLNGDVIQVLAERDPSKLPWGKLGVDLVLECTGLFTSREKASLHLQGGAKKVL
+LSAPAKDDVDATIVYGVNHKTLEPEKHVIVSNASCTTNCLAPIAQVMHELAGIEGGIMNT
+VHAFTNDQNLLDVYHKDLRRARAATASMIPTSTGAAKAIGLVLPELDGKLDGFAIRVPTQ
+NVSFVDLTLNLTREVKVEDINRAMREAADGRLKGVLAYNEVPLVSIDFNHNSHSSTYDAG
+FTKVKGRLVKVCSWYDNEWGFSNRMLDTAAVMFGRG*
+>PROKKA_00069 Phosphoglycerate kinase
+MGVKSLKDCELQNRRVLMRVDFNVPVNDGAIADDTRIRAALPSIHEALKAGARLMLMSHF
+GRPEEGKPESRFSLHPVARRLGELLGFDVPLVTDYLARDPEPGSGRAVLLENVRFNVGEK
+RNEETLARRYANLCDVFVMDAFGSAHRAQASTYGVARFAPQAVAGELLCAELKALGRALK
+APDRPLIAIVGGSKVSDKIGVLDALIERCDGLVVGGGIANTFLAAAGHPVGRSLYEPGFV
+DEAKRLMIAARERGVNFPLPVDAVVAEALAEDAEADVKPVHAVGAGDMVLDIGPETAVLY
+RPLLANAATIVWNGPVGVFEIDQFAEGTRAVAEAVASSGAFSIIGGGDTIAALAKFGVTD
+RVSYISTGGGAFLEFLEGKTLPAVDILEARASD*
+>PROKKA_00070 Pyruvate kinase II
+VTETMARFRRTKIVATLGPAVDEGDVLARMIAAGVDVVRLNLSHGTHAEHRKRVKAVRKA
+AAEQGRDVGVLIDLQGPKIRIECFRDGPIELKEDDAFTLDCGLGSNAGDSKRVGVAYKNL
+PRDVQAGDMLVLADGEIVLEVREVIGEQVHCRVETGGALSDHKGLNRRGGGLSAEALTQK
+DQVDIQLAAELEADFLAISFPRVAADVERARALLRAAGGTAAIVAKIERAEAVENLDEII
+DASEVVMIARGDLAVEIGDAPLPGVQKRIVRHARARNTVVITATQMMESMVTSPTPTRAE
+VLDVANAVLDGTDAVMLSEETAVGRHPVKVVEAMARVCLGAEAEPREDRDRRIGGDRFEL
+VDEAISMAAMSVSQHTDVTALVALTESGRTPLYMSRVRSGIPIYALTRHECTRRLLTLYR
+GVYPIAFEDEHESDEVLPDVAAALLERGLVTPHALIIVTRGKLRHVSGGTNSLHLVQVAD
+VLPEQVL*
+>PROKKA_00071 Fructose dehydrogenase cytochrome subunit precursor
+MNGHWAREKRRMRVINRLLGLSAVVMVLVLVSPTASASIASDAVAYPPVSLSNVPPAKAE
+EIRKGEYLTKLSDCMACHTDHGNGKAGKPFSGGLAIKTPFGNIYSPNITPDKKTGIGNWT
+FKQFDDAVRYGEGPNGYLFAAMPYNYYSMMNKDQVHAIWEYLKHVPAVNRRNKPLGMPPP
+FRWRWLQFGWRFMFVKPTQGEFKYDPKHSKAWNRGRFIVEGPEHCGACHTPHNMLGGSEK
+RFFLGGSDITGFWAPNISGLATKPHPIATIMRVFREGKGLGGGDLKGPMIDAIANSMRYM
+TPADMRAVAVYIQSVQSEVPPGPRPVAMDEVNLARGEKTYQTDCAACHATGIGGAPRVGV
+AKDWDALGKSPLFILFENVWHGVSIMPPKGGCKACTRDDVTSAIVYMLKRSTSRSSKPAV
+QATTSKSGIPRDTVSLAVGDKIYHAHCAACHASGAAGAPRHGDIKEWASRLKLGLDKLHH
+NALDGIGMMPPKGGCTSCSKDQILSAVDYLVDGSGGKALVEKSLSGKQGG*
+>PROKKA_00072 Cytochrome bd-I ubiquinol oxidase subunit 2
+MSGDSILRIFWWLVLGAWMSGIGVMLGRELGLTVLLRYLGRNESERRELLAPHIERPSEG
+HQVWLLLGGGALMAAWWPLFTATLFGGLWLVLLFMVLAVLVGPVGHGYRKRLSEHTRGPW
+DLLWAGISLAALLVFGLAIGATVSGVPLHFDAHMDAMWGGFFSRFTPYSLLVPGLMAITF
+GLWLAAARAAHECTGAVAARARALLLPVGGVTLLIFAGGAAWATQLPGYAVGGLPKVGAS
+PLDGTTFAVGGAYLERFLSHLPLVIVPVLTALAIVGALFFSWRGRLQRVGPLVVIAVVGM
+VATLGAMTYPVILPSFAEPAQSLTLWNAAAERPVLVAFLVWLGILVPVVLGYELWLRRRN
+AQTVVAGSTAR*
+>PROKKA_00073 Acyl-homoserine lactone acylase QuiP precursor
+MNATAPLQEQEPEPGNRRFPGLLMGGARQVARWSWQHRRYGRWPLRILLVLLLVLIILVG
+AGYGLLRGSLPQTEGTVRLPGLGGRVVVTRDAQGVPTIRAHNALDAWRVLGYLEAQDRFT
+QMDFMRRVAAGDLAALVGPAALPLDRIHARFDLRARAERIYLDAPSVERARLEAYTLGVN
+EGLDNLSVRPWAYLLLGERPRAWEPADSVLVIYAMGWMLQNPLGPRMRARAALRSLYPPA
+VTAFLGAPDTHWAAPMAGQPPALPPVPGTQLINLSASGKSRATAPVPSTAMYADTVAKLI
+LPQPFPGSNSFAVSGDLTGTGHALLANDPHLSLRVPATWYRARLIYPAPGATASQPVELT
+GVFLPGVPALVIGTNGHIAWGLTNSGGDWTALVRVKATAAGSRGGPLVYATPSGTATLAI
+QHVLLKVRGQTARPMSIRRTIWGPVIGTTADGALLVSHWALAQPGGVNLRFMQLDSQTTV
+KQALMVAGSAGIPVQNFLVADDQGHIGWTLAGRIPVRKAGCDYAVPQSWADGSCGWTGWL
+APGSYPSIVDPAQGYLATANNRVDARTAAVLALGDENFADGARAHQIVSDLKALAKRGKI
+TANDLHDVQLDDRAQFLQRWHDLLLNVLSPSALEFHPHRQALREAVVNWGARAAVDSVGY
+RMVRAFRNEVAASMFMPILKRLHTRDPGAGLPFSNQLEGPLWRLLQVRPHNWLNPAYPTW
+NALLVHAADAVIHRFWNPVSGLADATWGARNTVRINQPLAVALGPLGHWLDMPPTQLPGD
+SNMPRVQTPDFGASMRMVVSPQPSAPGLFELPGGESGHPLSPWYSDEFKAWAEGLLTPLA
+PGPARKTLRFIPWSRRVSDRPTVSTGSVVPAQSGQ*
+>PROKKA_00074 Chromosome-partitioning ATPase Soj
+MKKIVIANLKGGSGKTTVSTTLAAFWASEGYKTCLLDLDPQRAATSWLRRRPESLPSIHT
+LSLPNQTSGVTLSYALRIPRDTERLVVDTPAGLSGIALADTVRGAAAVLIPVLPGTMDSD
+AAARTVADLLLIAKLGRHSGRMAVIANRVRRGTLGAERLQKFISALDIPLIATLHDLQAY
+SHAILSGLGLHELPRRRIGGERMAWVPLLEWLERRELEITAQTALGPRSLLTQSAGQTPS
+DSME*
+>PROKKA_00075 Patatin-like phospholipase
+VLAGIAEWYGEDEAVPFRVISGTSAGAMNAAYLSANMENFAHGTQRLAQVWSQLEAQQVY
+RPEYRKVFGALLHWAWSLLSGGLGDSNPRSLLDNSPLRALLAENIDFDAIARNIERGLLR
+GVSVTVAGYSTERSLSYFQAETGVQSWWRQRREGRPVQMTLDHVMASLGLPIIFPAVKVA
+GEWCGDGSTREFAPLSPAIHLGAKRVLVIDTQYPAPQHVLGQDQAYPSLSKIMGYLFDSV
+FSDSLYADLERTKRINRTLDYIKRQSGHEPPELGLSHIDTLVIAPSRRPLEIASRYESHL
+PKSMRWILRSLGGDVSSGDQLLSYMLFQSGYCSEMVALGRHDAHARREEIGQFLGLSKIK
+VR*
+>PROKKA_00076 glmZ(sRNA)-inactivating NTPase
+MNLILLGGLSGAGKTGALDMLEDLGYQIVDNLPLSLIEPAIDAMLGDDARHHSRLAIGIA
+PHNTPEEFEALARQIEIWRTRPHGCTVIYLFCEPGTLVKRYRATRRRHPLTGPDTDLAAA
+IEIETTLLEPLAQLADACIDTTHTNIHQLREIIRARVNEGGDHPMALQIESFGYRRGLAQ
+DADLVFDMRCLPNPYWEPTLRELTGLDQPIAEYLETHGTVTRMLSNLVNFLNAWLPSYAA
+SNRSYLTIAIGCTGGRHRSVYMAEQLAAQLAHGGWAVTVRHRDLDTPTRDVKPILADD*
+>PROKKA_00077 Ribosome hibernation promoting factor
+MQNTITGRHLDVTPALKDYVNTKLSRLGRHHEPPTSTQIILSVENLDHKAEGILQVRGGT
+VYAEANETDMYAAIDILADRLDRQLVRHKERHASHHATPTARLNMEN*
+>PROKKA_00078 RNA polymerase sigma-54 factor
+MNSSPRLQTGISQRLGLSPRQTEALRLLALPRPDLEQILETALEENVMLERLEPETGEGD
+PEVATVMEQTEPAGEWDELSWSSSAGTGERPDMQTFEDIRPPDLRQHLIEQLVLERFSDR
+DFLIALALVDSLDDNGYLREDLDTVSQELDALDPSPELIEIEAILHRVQRLDPIGIGARD
+TAECLSLQLEALPPDTAGLVVARELIDGHCARLTQADMATLASLTCSDEDSVRRALSLIQ
+SLNPRPGNDYSAQTAEYLIPELRTYRTPDGWQVELYPGNHPRISINATYVAWLSANRLNE
+ASQSLTRQLEEARWLIRSLAQRENTLLRVARVLVRRQTAFLDQGVMHLAPLTLREVAKEL
+DMHESTISRAVQGKAMSTPRGVITLRHLFSNALSNDNDEAISARAVHERLRHLLNHEDPA
+APLSDAALAAALARDNMPIARRTVAKYREALGFASTRARKRPAHSVAISKG*
+>PROKKA_00079 Lipopolysaccharide export system ATP-binding protein LptB
+MSQLRAENLHKRYRTREVVRGLNLNVNSGEIIGLLGPNGAGKTTTFYMILGLVPTDSGNI
+YLDQRDITGLPIHARARAGLGYLPQEASIFRNLSVRDNLIAVLELGGHGTRAEQQRRADE
+LLDELGVTHLAKDKGISLSGGERRRVEIARALANEPAFMLLDEPFAGVDPVSVADIKRII
+DHLAKRGIGVLITEHNVRETLDICNRAYVMNRGTMLAEGSPKEIADNQTVREIYLGDKFT
+L*
+>PROKKA_00080 Lipopolysaccharide export system protein LptA precursor
+MHPKLFACCTALLACCAFPALGTPAPGSANASSSVSGVMTINADHSSMANTTGQGTEVTY
+SGHVIVTRGALRLYGHSAVIHGRSNTIGKVVVTGTPARFELREPGKPHVLGEADSITYNG
+KTDILQLDGQVHFSRPGEHFSAAHITYRIATRQLEASGNGNGRVHAVLSPAARTSP*
+>PROKKA_00081 Lipopolysaccharide-assembly, LptC-related
+VRLSRGWAVASAWAALLGAAALTSWLFLRSHDHSPATDLASHAVERPDYLLHQAIVTRFA
+KDGSRRYIIKARRIAHMPRNNIALLTRVDLDYFPVHGKPWHLQSDNGRLFANGTRLNLIG
+HVRAHELDTPIPVHFLTTEVTVLLPEARLASRYRVILRQGHRETRGTGLAANLQTGTLSL
+LKDVTSQYAP*
+>PROKKA_00082 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
+MSTPLAAIRLLALDVDGVLTDGRLWYSETAGEIKAFNAHDGAGIKRLMREGIAVALISAR
+QSPIVTHRARELGIIQVHQGVKDKGHCLTETAQAVGVRLAFCAFMGDDEADLPAFAIAGL
+RIAPANAVARVRDEADWCTQATGGQGAVREVCERLLAARQANAGGKS*
+>PROKKA_00083 Arabinose 5-phosphate isomerase KdsD
+VNRPASATGLIESGREVIQIEAAAVSALESRLNETFAAACGLLLACRGRVVVTGMGKSGH
+IGRKLAATMASTGTPAFYVHPAEASHGDLGMITSEDVMIALSNSGQTPEVVTIVPLIKRL
+GVALIALTGEPDSMLARASDCHLDISVSREACPLNLAPTASTSATLAMGDALALAVSAAR
+GFTPEDFARSHPGGRLGRRLLVRVADIMHTDDAMPIINESTRLGDALVTMSAKGLGMAMI
+TDVQGRLAGVFTDGDLRRHLDQGVNLDTPMQHLITRECTVATPDMLAAEALRLMETRHIN
+SLPVVTDDKPVGAFNMHDLLQAGVV*
+>PROKKA_00084 hypothetical protein
+MNLPANPRAQRRIDGLMAGQASLPGESGIDQTGRKMYAILGLDLDFSVWERLFQELLQVC
+PVHAIST*
+>PROKKA_00085 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
+LNRLLIRGGGRLDGEIRISGAKNATLPILAASLLAETPITIGNVPHLHDVTTTVTLLRRM
+GVDVTVGEHMALEVDSNTIKDMVAPYELVRTMRASILVLGPLLARFGCAEVSLPGGCAIG
+SRPVELHLKGLSAMGADIDVRNGYIYAKANRLRGARIFMDMVSVTGTENLMMAAVLADGE
+TVIENAAREPEVVDLANCLNKMGAEIEGAGTETLHIQGVAKLEGCYYEVMPDRIETGTYL
+VAGALTGGRVRVKRTRPDMMESVLEKLREAGAEITSKDDWIELDMKGRRPQAVTLRTAPY
+PAFPTDMQAQFTALNAVAEGSGAVTETVFENRFMHVQELVRMGARIQLEGNTAMIQGVER
+LTGAPVLATDLRASASLVLAGLVAEGETVVDRIYHIDRGYECIEEKLAQLGAHIRRVTS*
+>PROKKA_00086 Stringent starvation protein A
+MILYSRPDDPAAHSIRLVLAEKAIGVKIVEVEPDSPPEDLLHLNPYGTLPTLVSREVVLY
+DPRIIAEFIDERYPHPSLLPSDPVLRARARLFVSEIGGSWYELCDEVANGAGRGRTRARR
+ELTEAVVSSDELFTGTAYLLGGDYGLADCVAAPVLWRLPHLGVRLPREAKAIRGYMQRVF
+KRPTFVYALVASERAMIES*
+>PROKKA_00087 hypothetical protein
+MTEKPRPSRKPYLVRALHEWMGDASLTPQIIVDATVDHVDVPVEHVHDGKIVLNLSLEAV
+RDLELGNDAITCTARFGGVARSLWVPMKAVLGIYARETGEGVAFACS*
+>PROKKA_00088 Chloramphenicol acetyltransferase
+MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFI
+HILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIY
+SQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQG
+DKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA*
+>PROKKA_00089 Tyrosine recombinase XerD
+VTDRTVRTWIGEAVAAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSI
+SSTEVYTKVFALDVAARHRVQFAMPESDAVAMLKQLS*
+>PROKKA_00090 Replication initiation protein
+MAETAVINHKKRKNSPRIVQSNDLTEAAYSLSRDQKRMLYLFVDQIRKSDGTLQEHDGIC
+EIHVAKYAEIFGLTSAEASKDIRQALKSFAGKEVVFYRPEEDAGDEKGYESFPWFIKRAH
+SPSRGLYSVHINPYLIPFFIGLQNRFTQFRLSETKEITNPYAMRLYESLCQYRKPDGSGI
+VSLKIDWIIERYQLPQSYQRMPDFRRRFLQVCVNEINSRTPMRLSYIEKKKGRQTTHIVF
+SFRDITSMTTG*
+>PROKKA_00091 Sporulation initiation inhibitor protein Soj
+MKLMETLNQCINAGHEMTKAIAIAQFNDDSPEARKITRRWRIGEAADLVGVSSQAIRDAE
+KAGRLPHPDMEIRGRVEQRVGYTIEQINHMRDVFGTRLRRAEDVFPPVIGVAAHKGGVYK
+TSVSVHLAQDLALKGLRVLLVEGNDPQGTASMYHGWVPDLHIHAEDTLLPFYLGEKDDVT
+YAIKPTCWPGLDIIPSCLALHRIETELMGKFDEGKLPTDPHLMLRLAIETVAHDYDVIVI
+DSAPNLGIGTINVVCAADVLIVPTPAELFDYTSALQFFDMLRDLLKNVDLKGFEPDVRIL
+LTKYSNSNGSQSPWMEEQIRDAWGSMVLKNVVRETDEVGKGQIRMRTVFEQAIDQRSSTG
+AWRNALSIWEPVCNEIFDRLIKPRWEIR*
+>PROKKA_00092 Virulence regulon transcriptional activator VirB
+MKRAPVIPKHTLNTQPVEDTSLSTPAAPMVDSLIARVGVMARGNAITLPVCGRDVKFTLE
+VLRGDSVEKTSRVWSGNERDQELLTEDALDDLIPSFLLTGQQTPAFGRRVSGVIEIADGS
+RRRKAAALTESDYRVLVGELDDEQMAALSRLGNDYRPTSAYERGQRYASRLQNEFAGNIS
+ALADAENISRKIITRCINTAKLPKSVVALFSHPGELSARSGDALQKAFTDKEELLKQQAS
+NLHEQKKAGVIFEAEEVITLLTSVLKTSSASRTSLSSRHQFAPGATVLYKGDKMVLNLDR
+SRVPTECIEKIEAILKELEKPAP*
+>PROKKA_00093 Protease HtpX
+VLFTQIIAFVLVMVVYQAYDPAPPDYGWGWGLLLFITGPLLEWLLASVIARSGLRRLARP
+AADPARSLQRSEILLHLSALTVFFLFMVSYDLKAGLIATPLLAASETLSGLAALFYYALL
+LIPVWGHCHRLERAAGRALALDRRRYILEQARFVAPVAFPWFLVSALRDLLTLAWPGLTA
+WLETPAGDLAFLGFFLLVISWLFPPLVRSWWGCPPLPPGRAREICQMVLKVARVRVGGIL
+SWDVLQGRLVTAGILGLFPRFRYLLLTPALLEALSPTELAGVVAHEAGHVRLKHIPAYLM
+FFMAFFLLAYALAEPLDILLRLALLTLAQSDWGAGLLNSPDAGSTLSITFALPLLALMIV
+YLRFVMGFFMRHFERQADLFALNLMGEAAPLVGALEKLALMSGQTRDLPSWHHFSVAQRV
+SHLLTAQANPPAWLHRQGRLIKKALAVYLAGMVLVLGLGWGMAGLDWSRQVNQELALELV
+RHQLAQHPDDPRLRFQAGMLCYQLGREDRALSHFRRAFLAAPDNPELLNAMAWIFATSQD
+PRRRRPQVALVLARRAVSLSPLPHIWDTLAEAYFAAGQPVKALAAARAALEAGPKARLDY
+YRAQLERFKRAVEDLKKKGPAGRRPRPAAPAPGGRQG*
+>PROKKA_00094 hypothetical protein
+VEPTVPSPLLDRRQRGDAFLRRYWKLAAPLLILFMLALFVLPWVWFSFVEALCLQVGGAG
+LLYILGRLFTTAFNPAYHQAPEPQDGDAGRRDPSSSDPPPRA*
+>PROKKA_00095 hypothetical protein
+VVAFGFFHIETPMLLLEELFFFAPEFCDALVRLAQAPPERDWQGSWTGFEIPDPASRGDL
+HGAIAGRRLEGFIGALYARWPFPRDPHQFRQRTRGAAPREVVEQEAESFGRRREVVLEAR
+AGGGEFAIGQYRFHRTGFLALVDYVWRGGMPGWEGGRRPEWLLEAARRIQESDSPWLAGL
+DWDPARLGFTI*
+>PROKKA_00096 Glutaryl-CoA dehydrogenase
+MDFELSEELKMLREMAADFAKEQIAPYADKWDEEHYLPHEEVIKPMGELGFFGTVIPEEY
+GGNEMGWLAAMILTEEIARASSSLRVQINMLELGCAFTIYRYSLHDEVKKKYIPKLVSGE
+WLGGFGITEPNAGSDVMGMKSTAVDKGDYWLLNGSKTWISNADIANCIIYYAYTDREARG
+KGLSAFVLDLKNEDGSRPEGISVTRLDKLGSHSSPTGEIYLDNVKVPKENILGKPGDGAK
+IVFSSLNQTRLSAAAGGVGLAQACLDESIKYANEREQFGKPIAKQQMIQDQIAQMAIEVE
+AARLLVYKAACQKDAGNLGNTLEVAMAKWKAGEVANFCAQQALRILGAYGYSTEYPVARF
+YRDAPTYFMVEGSANICKWIVALDALGLRKANR*
+>PROKKA_00097 Acyl-CoA dehydrogenase
+LHLDQDQQDFLRHIQQVVETQLAPLALEIESQSRFPQQAREIFARAGLFTLAVPRSYGGQ
+GADATRLALMVENIARVSPSAALLVFPSNAVLRTIALTGSEEQKERLFGELVQAGDQCLA
+FCLTEPDYGSEAFNLQTRAERQGDHYVVNGTKTFITLGPNARYYLTFVRTGPAPKAGGIS
+ALLIPHDAPGLGFGPPEKKMGLHGSVTTNMYMKDVPVPVANRLRGEGEGWQVLTRVCNPM
+RVWGAAAMALGTAQGLFDQTLAYVKANAERLNPADRQSRDFALADMKMRIEACRSLIYRV
+CRMVDDPRTPPQQVDAFVSMSKCYAADTGMETGELASRILGMDLMRPDCLAGRLYLDAKA
+IQIFDGTNQIQRLVVAKSLALG*
+>PROKKA_00098 hypothetical protein
+LGEPLGSFEGETQTVMSVGDLAYWEPGNAFCIFFGPTPASSGPEPVAASQVYPLGRVEGD
+WQALSALGASVTARISAA*
+>PROKKA_00099 hypothetical protein
+MMYGDSSAGAGIEAQSLLCPRCGKAQPVRKKLLLVLPEGDKYAYFCAVCGEEVGSKLEES
+QGGPSFIPR*
+>PROKKA_00100 hypothetical protein
+MRSIVIDELSSPDVDRLSEHLDQTLTPSGLSGVYWLELPEDLLLPLQQEHRQSCGPHRVA
+VVVEEGCLRLELLVRAQESLRCNCTAYASSAQRDFLLDYLDRLIEELGLRT*
+>PROKKA_00101 hypothetical protein
+MSLPKRITAPLLSGLVLPGLGQLINRQLGKGALLICLMSLFFMSFLFLTVYQVSHAMSAL
+GEAAAQSADKWQALRAQLARQGTGWLWGLGTAGLGIWLFAVIDAARVGARLDRSAAEGGQ
+GES*
+>PROKKA_00102 Orotate phosphoribosyltransferase
+VVMEEYQKTLARLLAESGGLFFQEGLRLKDGRPTPYFVNLGVFRTGRLALELGRCFSLWI
+HHHGLDQDLDCIVGPSYKGSAIAQATAIALYELHGKEVAYDYDRKEAKTHGEATGHGYLF
+VTGAALQGGKVLIIDDVGTSMSTKLELLKKLSWLKPRLERPMELLGVVLAVDREQTQAVY
+DAQGRVREGVRGPDAMESFRQESGLEVWSLLGIRQALDYLYKEGIPVLIQGEMRPLDELT
+MQIAREYLELYGREEA*
+>PROKKA_00103 hypothetical protein
+LNRSLQNQISARYWSSHISSRNNIQNNENCACDPRLAPCLLVCRASLIPFLPFLEGAKLK
+KLGAFYLGRRRRLQAGKHAGSSRHQSGPGAPRRFLFGGNCDPPWRATHPPPRRQGRPAGR
+PLSTMQNKPGKGITLLSSRPPAVPPRRGRSPAAPPSPWRPAWP*
+>PROKKA_00104 hypothetical protein
+MKDKRQAEDESAREPFTPEEQDVDKYKREVEELKAKLAAMEKEEQQDSSPAEEAPQEDEK
+KEE*
+>PROKKA_00105 HTH-type transcriptional regulator cbl
+VEGLFDKLSAIQKFANDLRGNRSGVLSIASTPTLTYAFLANALKRFREERPGVRILLEVT
+HTQRTLELASAGQIDLGFIHGPSENPLLQFERLAASEMVCVLPPDHPLAAQPALGPRDIS
+AFPLITNIRNSIAPRIEEAFRKQGVERDFAIACNHTMTVYMLVEAGAGIGLVDPWVQAER
+FPTLVRRPFRPRVEVSPRAVHSRSQSLSRLAEGFLAVVREEAAVSQ*
+>PROKKA_00106 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00107 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00108 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00109 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00110 tRNA-specific 2-thiouridylase MnmA
+MCNLLIKFGAFNDRFGKDFDRISTGHYATRYNTDEGVFLSTAADRVKDQTYFLGQITPEQ
+LAKTMFPIGHLQKKEVRKIASDMKLPSAHRPDSQGICFLGKINYTDFIKKYAGEKPGEII
+ELETGKVLGTHKGFWFHTIGQRRGLRLGGGPWFVVKKDIEKNIVYVSNGYDPIAQYDDKI
+WLEDLHFLNKVHDYSKLNEIKFKIRHQPEFNSGKLVRDEKGIRIVSENKISGIAPGQFAV
+VYDEEERTCIASSVIAENPEIAV*
+>PROKKA_00111 YhhN-like protein
+MNPLLLFILIVSGGLYLAGHYLHKPILKYIFKPFTTFIILFFAFMQLPDVSVQYKDYILI
+GLLISLIGDIFLLWPEKRFIHGLGAFLLAHVLFILAMVSDFGPYYNWQYLIPIALYMVIF
+LWIILPKSGKFVIPIIVYALVLMVFFWQAAGRAIYLAESSSMQAMFGATLFVASDSILAY
+NKFVKNYKWAEFFIIITYWAALYFIALSV*
+>PROKKA_00112 Alpha/beta hydrolase family protein
+MDWIIVIILAILLVAFIILFLLIQKGFRNPVSEHTIPEDLPFDVQEVEYPTKNGKTIYGW
+WIPADPKAATVVFVHGWGRNAQRMMPYLRKFCCGKFNLLAFDARGHGNSDHDGFSNMLQF
+SEDIIASMNFIEQEHKAENNMFYLIGLSIGGAASIYAAGHDPRVKKVLTVGAFAHPASVI
+TKQIKDRHIPYFPMIWFLYRYMKYVKNLDVDAIAPEKHIAKAQAHFLLVHGEIDQTVPVE
+QGKRLKKAAGDKADLWLMPERGHSDCHLEHGFWEKLMEFFEAPKTKVQKS*
+>PROKKA_00113 Apolipoprotein N-acyltransferase
+MKKFHLLLLSLLSGLLLAAAWPLHGFTPLIFIALVPLFFVQQQMGDTGKRGMLLYAWLTF
+LVWNGLTTWWIWNATPVGAIVAIVLDSLFLAIVFQVFHLSKKWLFNNKQGFFILIFYWIA
+WEHFNANWDLSWPWLTLGNVFASKHLWIQWYEYTGVLGGSLWILSVNILIYNIIKSFLEK
+RKQRALYTTILTVLFIAVPIIISLNIYHHYKETKNPVNVVVVQPNTDPYTEEFNLPPSAL
+IKRNLKLAEQKVTDSTDYVVFPESTIQEQIWEGSLNRSQSIKTLRNYVMEHPNLSMVIGA
+STFRWLKPGEHRTNAARFYKKGLYYYAYNTAFFIDHSPYIQVHHKSKLVPGVEKMPSWPI
+LKPLEHLALNLGGTVGTLKEDDHVSLFTNDSSGTKIAPMICYESVYGDYVRQYVAHGAEL
+IFVITNDGWWGNTPGYRQHFSFAILRSIETRRDVAQSSTTGYSGFVNQRGDVLQRTKYDE
+KAALSQTLNLNDKLTYFMKKGDYLAHLAGFFSILILLAAIVQGFLKKRNLPH*
+>PROKKA_00114 Putative NAD(P)H nitroreductase
+MKTFLDLVNQRQSDRKYIDKPVEKEKLMRCLEAARLAPSASNSQPWTFVVVNQPELCQDV
+GKAAMGPLYSFNKFASQAPVILAIIMEKPKVITEVGGRIKKKEYPLIDVGITAEHFCLQA
+AEEGLGSCMLGWFDEKKVKELLHVPEEKSIPLLITVGYTPENYKHRKKIRKPIDSAVKFN
+TYG*
+>PROKKA_00115 Transcription antitermination protein RfaH
+MAKQKTQEKIWYAIYVKSRAEKKVAIELEAEGIDFYLPLEKRLKQWSDRKKWVEEPLFRS
+YIFVHISHKDYYRALVQNTVKYVTFEGKAVPVPPEQIEAVKVYLEEKEPIQPNDEDWETG
+KEVEVISGKLTGLKGVLMEVKGRSRVKVEIEVVSSSIILHIPKSKLRLLE*
+>PROKKA_00116 Colicin V production protein
+MGVNLLDIILAVPLIFFGYHGYRKGLIIEVTSLAAFILGLYFAFYFSNFTAGILKEYFTI
+QTKYMAAIAFVVTFIVVLLIVLAVGKIVEKFIDILLLGFLNKLAGGLFGVLKGALFLSII
+IFVINYFDASHSIIKQKAKDNSVLYKPVESIAPALYSWLHLKNFDFHLPSEESVIKTITH
+RANPD*
+>PROKKA_00117 GDSL-like Lipase/Acylhydrolase
+MGLSYRINFKLGANAMVISDPSMPVPASLQFRQLKSDEYVMLDIPTDSLEVAYWGTKKPV
+PAQYVLTEAQTAKVESAITSYNAEIKSLAKKYNLAFVDFNSIMKSIEHGGLTVDGIHFTT
+AFITGNLFSLDGVHLTPQGNAVVANYFIQAINKQYGSHIPSVMVSDYPSVVFP*
+>PROKKA_00118 47 kDa outer membrane protein precursor
+VKWDDNWALKLLIQNISLQAIFYQPTISFNLGNKFGVGAGLVYATGNVKMNSALNYSGNS
+GFNLNGKTHNFGFNVGVHYKISDQWSLGATYRSEIKMNVKNGNAAFFVPGSLSSIIPPSN
+HFSASLPLPANFDFGVAYQATKKLLLAAELDWVRWSVYDSLSFHFATNPQLLNNSSPKLY
+KDQWIPRIGAQYQVSKKLMVRAGAYYELSPANVSGYYKTNTVVPGIGINYHF*
+>PROKKA_00119 hypothetical protein
+MSGKLQAEFRSDLKWQPAILRKILILPSKQVLIILSLMAVVVVQARPPLF*
+>PROKKA_00120 Transposase DDE domain protein
+MKIIKLAMFSKTQTMLQHKDINKLSELKNGFTQSWVEPDFIFRSLKCFSFSSLNKGLSPL
+KAKGYSFEWVMSLLISLPFMGISSVNRLAGVVEAKKDVFYRLKNNSSISWRYIQWLFACK
+FNTITSESTGNNIQPRCLIFDDTVIEKTGRFIEKVSRVWDHVQNRGVLGFKLLVMGYWDG
+TSFLPLDFSIHREVGKNKEYPYGLRKKDYRKQFKKKRSSQTHGYDRSKEAGQSKIDNMIK
+MFKRALSHGFSIDYVLVDSWFTCEAIIQAVTQVKNQTVHLIGMYKIARTLFEYQGTKQTY
+SQIRNRLGRPTRCRKLRLYYLQATVGFKGHQLQLFFTRQGKNGKWKVLLTTDCSIGFIRL
+VEIYQTRWTIEVFFKESKQLLGLGHCQSNDFDAHIADLTITMIQHMLLTLRYRYDTYESK
+GALFENVKETIAIRKLNERLWGLFVELLQILTDLFEIVDAMELLEHIITNGQALERLKLL
+FDLVPENNEAA*
+>PROKKA_00121 Histidine-specific methyltransferase EgtD
+MSQAEAPVIIKPNFKITNFLSKEPRSSLIHEIFSGLTAKQKYISSRFFYDRKGSALFEEI
+TKLPEYYPTRTEKSILSAHAKEILGNPESLVIIELGSGDCSKISILFDNFPEQKMSNVKY
+IPVDVSESAIIKSAEILSSRYEGLKIHGLLADFLKHLDLLPGATPRLICFFGSTLGNMTR
+NQATDFLWNLKNIMNPGDRLLLGLDRVKGPEILYKAYNDKQGITAQFNKNILNVVNDVSG
+TNFKTSDFGHLAFYNQNENRVEMHLKALYDMRITSKHFRDDIFIVKGESIHTENSHKFLP
+EQIEQLALSSGLKFQASFTDVNKYFSLNLFEYPKLK*
+>PROKKA_00122 Thiosulfate sulfurtransferase YnjE precursor
+MPQFFKQLSTRELTERLNNKDVQLIDIRPVDAYNGWASRGESRGGHIRGAKSLPFAWTKY
+VDWIEMVHRKKILPENEIVIYGYPDEGFRLVANRFKKSGFEKVSIYLNFLNEWVPDTTLP
+MEKLFRFQNLVPASWVNELISGGKPQHFENDKYVIVHAHYRNRDAYLSGHIPGAIDMDTL
+AVEDPETWNRRSPEELKQTFEQHGITVDTTVIVYGKFMFPDNSDEFPGSAAGDIGAIRIA
+LIMMYAGVKDVRVLNGGFQSWLDAGYEVSYADEPKKPVADFGATIPAHPELAVDTPEAKE
+MLASSRAELVCVRSWPEYIGEVSGYNYIEPKGRIPGAIFADCGSDAYHMENYRNFDHTTR
+EYHEIEDIWKSNGITPDKHLAFYCGTGWRGSEAWFNAWLMGWPKVSVYDGGWFEWSADPA
+NPVETGIPENYPNRN*
+>PROKKA_00123 hypothetical protein
+MKAIWNNTILAESNDIVKIEGNAYFPINSVKKEYLKTSETHTVCPWKGTASYYSLEVNGK
+ANPDAVWYYPEPSDLAKGIKGRVAFWKGVQVVKD*
+>PROKKA_00124 hypothetical protein
+MIKYYLLLAFEKKTLIRAIRVAILVGIILNLINNPDFIFHFSTNYLSLGRVLLTFIVPFL
+VSTYSSVLSNSALRTGSVSHIDAILKCKSCNKTHIHVPIGHEVEECPICKKETRWRPVRI
+FSGSGNRDELLKSLALFARYNPTPLFRINSDSIINEANQAAKDIFGSDELTGKNLAGIIP
+EIKDINLNQLIHDGAIKKTIIHKEGRDYNITLKGIPELNSVHGYLNEVTNFVEPEQKG*
+>PROKKA_00125 Putative thiamine pyrophosphate-containing protein YdaP
+MKENLEWHKVLEKKEDLPENRIITVNAGSKQIALSHFEGKICALDNHCPHQGGPLGEGSI
+ENGILRCPWHGWDYHPCTGKAPGFDDGVATYRVEERGNGIFVGIPPKKPHKTTLSDIMVE
+TMVHWGVDTVFGMVGHSNLGLADAFRRQEEKGKLKYIAIRHEGAGAFAASAYGKLKGKPA
+ACFSIAGPGATNMFTGLWDAKVDRSPILALTGQVATQVVGTGNFQEVDLVRAFQTVAAFN
+HRVQKDSKHAELMSLAIKHALLKRDVSHLTFPDEIQEILEGKEESQTPEGRMGELQISPA
+AGSMDKAVDFITKSKRPVVIVGHGARFVMEQIISFAEHLNAPVLTTFKGKGLIPDDHPLA
+AGVLGRSGTPVASWFMNESDLLIVLGASFSNHTGITPKKPIIQVDFDPLALSKFHKIDVP
+VWGELSTTVNILMKRLPVKPNTVDQRTELAQRWKIWRTEKQKRLLEDRGKGISSIAVFDN
+LSKLIHPEAVVCVDVGNNAYSLGRYFESKNQSFLMSGYLGSIGFAFPAALGAWAATRGKR
+QIVAVAGDGGFAQYMAELATSVKYNMNIKLVLLNNSELGKITKEQRSGGFKKFATDMHNP
+DFAEYARGCGALGIKVSKRKDLKTKMKEFLDYKGTALLEIVTDVLLV*
+>PROKKA_00126 hypothetical protein
+MQEYIKTDRQIHWLSQAIAKVNRDYVPAKKDDSHTNLFLDAAGKRLFGRWINTPKGKFIL
+ALNLKTLSFEWLDNPLSVKTSISVFDKEGSSIEKEIREFPVSMGMSSKDISKPLHFEIPD
+YGFSIIKSNRISSFGIKQWIYYRGLANFACLSVLGYLQSESEIRIWPHHFDTGVYAQVTD
+SLGFGFGWAMADSMIGEPYYYLSGYKNSSIIIYNNLSKLNFGRWVTGEQWNGTVLPLHVL
+ADNSTAKALEIINTYIKESIDWFLNL*
+>PROKKA_00127 hypothetical protein
+MNQEKKKLVLLAFVLLLAGISPNIFPAAQSGIASMSSLAVVLLIPSVVLIFILAILSQAL
+GYNDLRKQILNGILAGLAGTVGLEIVREIGFHLGGMPGDMPKLLGVLLLNRFASGPDFWS
+NVAGWSYHFWNGAAFGIIFSLIIGRGKIWMGIVYALLIGTGFMVSPATTSLGIGVFGLHF
+KDGYQFLTTVYLAHIAFGSIVGLVVYKKNKDAPNIFKRLKLAFS*
+>PROKKA_00128 hypothetical protein
+MMVMSQLDQGKILSMTGLSVKSHSFFIGNPNVGNKAFSADPAAGLVIPVRVNVYEENGKT
+YVSYFKPSDLFGSFKNAKVKMIGQMLDKKLGMMLKMVTR*
+>PROKKA_00129 hypothetical protein
+MSVLMHNNQDGAVRFVFNNLSNKQTKQKSAETLKKLDLYKTMSKFKSTGVVYFFDAKNKS
+LISHISLARSNKQLAEALTNSEKMAK*
+>PROKKA_00130 hypothetical protein
+MMKKLMNILFLSCLKATELIEKKLYFKLSLKEKVQLKAHKMMCDACTNYEKQSIFLDKGI
+SHLNQSKIKKEDLEEIKKSIQQKLNELK*
+>PROKKA_00131 RNA polymerase sigma factor YlaC
+MPQTKTTDLTYLVETYTEEMVSWAMYKVSDAELARDLVQDTFLAAAEKMDAFKGESSPKT
+WLFSILNHKIIDVYRNKVKQPVSFDSQVFSTYFNERGDWKKEKEPKDWHQEEKQLLDDSA
+FQQVLQKCLESLPEKWSTCVKMKYLSEKKGEIICQELGLNPTNFWQIIHRAKIKLRDCVD
+QNWFRS*
+>PROKKA_00132 Bifunctional PGK/TIM
+MKTIDNYDFKGKKVIVRVDFNVPLNDQFEITDDTRIRATIPTIQKLRESGGAVILMAHLG
+RPKSGPEDKFSLRHVVKNLSEKLQTEVQFANDCIGDEAREKAAALKGGDVLLLENLRFYK
+EETAGDEAFAKKLADLADVYVNDAFGTAHRAHASTTIIAKFFPNDKMFGYLMENEVKSLD
+KVLHHAERPFTAILGGAKVSGKIEIINHLLDKVDNLLIGGGMMFTFIKGDGGKVGSSLVE
+DDLIETANAAREKADKLGVSLFIPKDAVTADKFANDANQKCRPSGEIPDGWMGLDIGVET
+SETFRQVIENSATILWNGPMGVFEMDAFAEGTVDVAQAIVRATEKGAFSLVGGGDSVAAI
+NKYNLQDKVSYVSTGGGAMLEYMEGKTLPGVAAIKDE*
+>PROKKA_00133 Methionine aminotransferase
+MSQLANDHKAINLSQGFPDFPISEELIDLVHYYMRKGYNQYAPMQGVLPLRKAISTMFQK
+NYGIHYDPVSEINVTAGATQALFSAISAFIKDGDEAIIFEPAYDSYAPAVKINGGMVKYA
+HLEFPDFNINWEDFPRLITNRTKLIIINTPQNPTGSVLSEDDLQRLERITSGTDIIVLSD
+EVYEHLIFDGITHQSVCRFPELAKRTLVIGSFGKTFHATGWKTGFVLAPERLMKEFRKVH
+QFTVFASNTPIQHAIADFIGNEDNYKNLGKFYQQKRDMFVKSLNGSKFNVLPCYGTYFQL
+LDYSNISDKNEMDFARWLVEKHNIAAIPIAPFYHKKDDHKVLRFCFAKKDETLVEAGEIL
+SKI*
+>PROKKA_00134 2-oxoglutaramate amidase
+MNDLKILYIQSRLAWEDAETNRKHFEEIIQKEAQHHDLIVLPETFTTGFPVDPVPFAETE
+DGESVLWMREMAAQTCAVVTGSMLLKNDGVYTNSLIWMRPDGTYERYNKRHVFRMGGEHE
+KIHPGDKILLVELKGWKIRPMVCYDLRFPVWTKNHYEKDAFEYDLALFVANWPAVRAYPW
+DQLLIARAIENEAYVLGVNRIGKDGLGNDYNGHSKVVDAKGNVISEAPENEEAAISVKLS
+YEALQKFRAKFNVGQDWDSFTIQK*
+>PROKKA_00135 Molybdenum cofactor cytidylyltransferase
+MKRLGKHFAVLILAAGYSGRMGMPKAFLPYDANRTFLEKIVSEYLEFGCNLVGVVLNEEG
+MKLYEKMQLEHKNNITAILNPAPEKERFFSLQTGLKRLKSEGAVFLHNVDNPFLTQDILQ
+ALASAFKTQAYVVPTYHEEGGHPILLSQEIVKALIETSDYEQNLRVFMESYDQIQVPVSD
+PNVLANINSPQEYERLFGRSF*
+>PROKKA_00136 Free methionine-R-sulfoxide reductase
+MDKEKKQKRYQRLYKQIQDLIVKSSNNPLSNMATINAVLYHKMETFFWCGFYLYQDGKLQ
+VGPYQGSLACINLAEGTGVCQAALTQQKTLTVPDVEAFPGHIACDSRSKSEIVIPVRNRE
+NELVGVLDVDSKEHNSFDEVDEAELEKIVRLVYFPEG*
+>PROKKA_00137 6-aminohexanoate-dimer hydrolase
+VLIKKAMNRVERGKYGEVHSVLIYKDGKLVLDEYFKGHDYKWEAKKHYGPMVVWDADRAH
+SAHSVSKSITSLCVGIAVDKGLIKDIHQSIFDYLPEKYQYLNVGDKKYITVENLLTCSSG
+LLWQEWSAPLSSKRNDQVGIYFHKKGPLDFVLNRPFVAVPGQRFNYSGGGVEVLGEIVKN
+VSGMAFDEFSQKYLFEPMGIKTASWALKYPTGEVHAAGSLKIRPRDMIKIGAMMLNNGIW
+NGKRIVSEDWVEKSRKPWGNNRGIDLPGEDLRDMGYAYNWWTKNEKINGKAVHWFSANGW
+GGQQIIVLPEINTVVVLTGANYNRKVKQYALLADYIFPAIK*
+>PROKKA_00138 Demethylmenaquinone methyltransferase
+MQQMEILERYLNENKTINEFKKVLWIYDFWGKLTEGKAAKKVLEFAGIKNGISVLDVACG
+TGEMLEKVVKLNPDGQNSGIDLSPDMIAKARKKLSKTGHLNFNLKQGSALDLPFPDNSQD
+LLINSYMVDLLPVDCFDKVATEFFRVLKPGGKVVMSTFSFGTKKVHRFWFWVARKFPALL
+TGCRPVSFKHFLIKAGFEIVKDVEISQNTFPSQVLMALKKS*
+>PROKKA_00139 Transposase IS200 like protein
+MELNVQIDHVHLVVSVPPKVSVSRLMGILKGKLAIKLFKSYPSLKEKPYWGNHFWARGYF
+VSTVGIDEDVIKRYVKYQEEEEKKIETQQQRFDF*
+>PROKKA_00140 Rubrerythrin
+MKSLKGTRTEQNLLKAFAGESQARMRYDYFASQAKKEGLEQISALFTETSLNEKEHAKRF
+FKFLEGGPTEIVAAYPAGIIGTTLENLRAAAEGEHEEWTELYPEFARVAEEEGFKEVAAA
+FKMIATVEKAHEARYSKLYKNLEAGKVFQRDGVVVWKCRNCGYLHEGKKAPKKCPACLHP
+QSFFEVETFGY*
+>PROKKA_00141 High molecular weight rubredoxin
+MNIEAFYSLSYGLYIIGTASKGKKNGYVANTAFQVTASPEQIAISCNKDNLSEQMIDESG
+YFSLSVLEKDASKEIINRFGYKSGKTLDKFEGTKYFETNNGIPVVTEECVAWFECKVEQK
+VDVGTHIIFIGRVLNGEYLDENKESLTYTYYRQVRHGLSPKNSPTYVDKSLLPEKEKKEE
+KAEETPAEKPKGKSMQKWECIVCGHIYDPAVGDPEQNIPPGTAFEDLPDDWVCPDCGAEK
+EDFEPIG*
+>PROKKA_00142 Efflux pump membrane transporter BepE
+MFSKIFINRPITAIVISLFIIIVGIISIFKLPVAQLPKVTPPVVSVSGHYTGANASDVEK
+AVATPVENSVNGATGMLYMNSTSANSGSFNLNVTFKIGTDVNVDAMEVQNRVNLATPILP
+AEIRQTGLSVKKASTSMLEIVGLYSPHGTHDEKFLSNYAALYIQNALSRVDGVGDVHVFG
+NSFAMRVWLNPQKMANLHLTTQDVINAVREQNAMIPAGSVGASPAPKGQTFQVTVQVKGR
+LVTAKEFGNIVVGTNPATGSVIRLKDIARVKLGSSSYAGTPRLNGKVGCGLAVYQTPGGN
+ALETADLVKAKMEQLSKNFPTDVAWTTMVDNTRFVQSSIDEVVKTLFEVLLLVIIVVFFF
+LQTWRPTLITMLAVPVSIIGTFAIFTLIGFTINTLTLFAMVLAIGIVVDDAIVVVEAVQH
+NIDRYGLTAKEAAIRAMSEVGGPVVAIALILTAVFIPVTFMPGITGMLYKQFAFTIAISV
+LLSAFVALTLTPALCSIMMRPNPVNENSKGLNRMFYKFNIWFDKTVENYGATVRKTIKHA
+PLMFILLGAIYIGTGLFSKYTSTSFLPNEDQGMVMAIAQLPPDASTQRTVKVLNQFGKIL
+NHNKNVKRYFLAPGFSVLQGAQMSNFGTAFIRLTNWSKRKGKNSSIQAVIGQLMGASSQI
+KGAKFMIIAPPPIRGLGRTNGFSFVLKQSTGSIQDLEKVQNKFLAALNKRPEIQMAYSTA
+TFNYPDIRVTIDRVKAKKMGVSLSALDNTIQTFLGGYYINDFTLFNRTFRVYAQADSSYR
+ANINDLSEYYVRNNQGNMVPVSALVNITRGTSAPVITHYNMDRNVNISGNAAPGYSSGDV
+IKVLRQVAQQVLPEGYSYEFSGTTLQEIEGGKTSTFIFILAIVFVFLFLSALYESFAVPF
+AVLLAVPIGIFGAYLSLHIGGLSSSIYAQIGIITLIGLAAKNAILIVEYCKMKYESGVPL
+VQAAVEAAKLRIRPILMTSLAFDLGVIPLMIATGAGANARINIGYTVFGGMLTATLLAIF
+FIPLFYVTIIKIRDRKKKPELVKTED*
+>PROKKA_00143 Multidrug export protein AcrE precursor
+MKSEVNGRVEDILFKEGGSVKKGQPLYTINKSLYQAAYDQAAAQLNIAETNWATDTTDAR
+RYKNLWAHNAVDKIQLDHAIAKVNVAKASVIAAKANLESAKTNLDHATVRAPFSGSTDVS
+KVRLGDVVVAYQTPLVTIVDNSNMNADFFITENDYLQLGSSDKSIKEKLSHFRLVLPNGK
+LYPYKGKLYAVDNRVDPTTGTLMVRLKFPNPEDLLKSGMNCVVRSTQNSAGKVVVIPQQA
+VTQLLNEFFVYTVNSKGIVSQQKVELGAEYGNMQVIKSGLKPGTKVIVEGIESVRPGAKV
+KTVPMKTGGMAKQSKPE*
+>PROKKA_00144 hypothetical protein
+MEFKFEKLIIWQKAMEFGEEINSIAHKFPKDEVYNLSSQIRRAVDSIALNISEGSIGQSN
+LEFKKFMSYAIRSLAEVVSCLHKAKRRNYITEDEFKKQYEFAYNLMNMMVAFREKIK*
+>PROKKA_00145 Outer membrane protein TolC precursor
+MLLKKLNQNKFFSAFLAVSFLLSGFSVSLKAQGQKAVYQFNLNDCIHYALQNQASVKNKI
+LSEKISRENVKEAYSKLMPQVSAGAKYQYTIKRQVSFIQGNPVLFGVPHQLQGYLNVDQT
+LFDPSVLGSAKAAHLSENLSKENTQLSKIDVAANVKKAFYGVLVFREQLNLLNANIKRDT
+KSLADTKNQYKNGLAQKVDVDRIQVLVNNDVTARANASRNLNTLIQTLKYHMGMPIKDSL
+VIKGTISDAMLTEILPENNPMFYKNRVEFQQAQTTLAATKLLKSNVIRSYFPTLSAFYTL
+EAPYNSNTFPGLFKDKLYPTSFVGLQLSIPIFSGFNKHYQYQAAKMNIQISKNNISDLEN
+NIKLEYGNYFRQYKSDIANLKTQKENTKLAKLNYDNLKYQYDNGVQPLIEVLNAETTLLQ
+AQDNYINALYQALVDKVDLDKSLGKLKY*
+>PROKKA_00146 High-affinity nickel-transport protein NixA
+VVLLLSLAIIIAFRKFSSNIHFLENIGGVLGTVVSASFLTLIGIINFFILKNLYRMFKLY
+KKGEGAEKRIEEITENLLNKRGLLNRFFRFAYRSIDKSFKMYPLGFLFGLGFDTATEVAI
+LGISATVAKDSQLPIWGILAFPLLFAAGMSLMDSLDGLIMMRIYDWAMVDAVRKVFFNMV
+ITGTSVFVALAIGTIEWLQVVSIEAKESLSFFSFLNHLDFSVLGVGVVIIMLISWLSAFV
+YYRKVLS*
+>PROKKA_00147 Polar-differentiation response regulator DivK
+MDAGEEKASPKKTILIAEDDETSFFFLKFVLAKENVNILYAQSGQEAVDICEAHPEIDLI
+LMDIKMAGMSGIEATQLIKKRNPRVPVIAQTAFALSSDKENILKAGCDDYITKPIRKEEL
+LEKVNFFLYSKKES*
+>PROKKA_00148 manganese efflux pump MntP
+MLAISIVILLILSFQVMPVALGIDSHKMNVFHVASSIFLLILGQVLLFLLGILLGDKFMY
+LMSGFKRFVLFIGFFIIATRMIMEALEIRKGKRTYLLDKAKQFILPSIAQAINTFLAGIL
+FQLLIFNLSKDLIYLGIFALAFSVPFIFIKNEKQSMLAVSLLYMVGGGILSILSFYFLFI
+*
+>PROKKA_00149 6-carboxy-5,6,7,8-tetrahydropterin synthase
+MKKHLNINEPTRIRITKEFKFEMAHALKGYDGLCRNIHGHSYELMVTVSGFPIEEENHPK
+LGMVMDFGDLKKIVKEEIVGQFDHALVLSKKMPVPLVDELKNQFERIILTDYNPTSEMML
+IDFAARLKARLPENITLKHMLLRETVTSYAEWFAEDQD*
+>PROKKA_00150 Gram-negative bacterial tonB protein
+MYKKLLLLSLTFFMFTSFTNIASAQSNNIEIARLKQIHKLLDYRFVGGFYGFEKLFFQTV
+SYPDEARQNCTLGIMIASFTVNCDGDLVGIRIRNSLGKPLDNQVSKFLKATKGHWNPCQD
+KKFTHFEIPIQFTLKGTETDSTAAALVYVGKSAGYSCYPDSYYSVPRLFPGGIL*
+>PROKKA_00151 hypothetical protein
+MGKIVGIRFKKGGKVYDFDAGHFVLSVGDMVIVETEQGQALGEVVRPPVSHVLPELAPKN
+RCCEGCEDSGDEPAQLKQVYRLATEEDLRQLVENAKLEKEAFRYCQERIAARRMDMNLVK
+VECFFDRSKLMFYFTAEGRQDFRELVRDLVSRFRTRIEMRQIGVRHEAKLLGGLGSCGRE
+LCCATFLRDFEPVSVKMAKEQNLSLNPTKISGLCGRLMCCLTYEFETYKGLKQGMPKLGK
+RVSLNSGLEGKVIRQNVLKRQLTVILSDGREFTGTPEELEQLEPLAKPQAPPKPRGGQRQ
+QRNQQQGKGQQQTNSGGKSRSRNRRRKKKGS*
+>PROKKA_00152 Bifunctional transcriptional activator/DNA repair enzyme AdaA
+LHACRSTLEDPTRKQPRNTSTAKAYLDEHFQHKLTLETLAGVAHLSVRQLNELFRRQIGM
+TPHHYLTEVRMQQAWQLLEGTDLSVQAVAERVGYSSLAAFSDRFHQHFGHPPSHFRRTGK
+TLRQNR*
+>PROKKA_00153 Aromatic amino acid exporter YddG
+MSSPVRTATFIGAISVVLWGTLALLTKLTGGRIPPFQLMSMTFGIAFLLMAVRWWSRGES
+GLGYIRQPFPAWLLGVGGLFGYHLAYFKAMTLAPAVDVSLIAYLWPLFIVLLSALLPGHS
+LRAQHLVGAVLALAGCWLLVGRNSQGFDWTYADGYLVAFGCSLIWSSYSVLSRLVRSVPT
+DAVGWFCGVTALLALGCHLLWETTVWPVGTLQWLGVIGLGLGPVGIAFFTWDHGVKYGNL
+PLLGTLAYSAPLISVVLLLLAGFGQASGMLFLASALIVAGSFVAGRAKHASPELAEEPVP
+E*
+>PROKKA_00154 hypothetical protein
+MKDIQLESTIICPACGHQKTEQMPTDACQYFYECESCHTLLKPRAGDCCVFCSFGTNPCP
+PVQQGDDCCASD*
+>PROKKA_00155 hypothetical protein
+MNKGTVLRVARPTDQLEKIAQMYMEGLGFERLGEFREHDGFDGVMLGLRSHAYHLEFTQC
+QHEKAGRAPTQDHLLAFYIPDAVEWVRTCEAMVKAGFVCKPSFNPYWDRLGKTFEDVDGY
+RVVIQKEQWLD*
+>PROKKA_00156 Cyclopropane-fatty-acyl-phospholipid synthase
+MSHTSSDHSIAFPLRQKSKLRHLAQELLAKADIRIDGDRPWDMRILKEGVLERILGEGSL
+GLGESYMDGEWDAERVDEFVYHLIRAQLDREVRPWNLILHGLRYRLFNMQSLRRAWMIGQ
+RHYDLGNDLYEAMLDPLMTYSCGYWKTATHLAAAQEAKLELICRKLQLKPGMRLLDIGCG
+WGSLMAYAAQHYGVECVGVTVSEEQVKWARHQYKGLPVEFRLQDYRTLDEQFDCIASVGM
+FEHVGHKNYREFMQVAHRCLDDGGLFLLHSIGNNSRDSGSDPWIDKYIFPNGELPSVGQI
+GDAADDLFVIEDLHNFGADYDKTLMAWHANFEAAWPKLAYLGERFRRMWTYYLLSCAGTF
+RARDIQLWQWVLSKRGVQSGYIRPYF*
+>PROKKA_00157 hypothetical protein
+MQTLNIPSLATVTAITLLTTACANNPTPETLQSRGLHPLDTTQLHQLYSKTLQFDWRNAR
+SRSGSGEYQPNGEISIEWSGESFNGKWRILNNHFCATYASIHNGQEQCYMVYQTGARRYV
+AFLNGDYSYSFNVKKVK*
+>PROKKA_00158 hypothetical protein
+MLSRAIMAPMDLVLDTAEAQRMALFFDHILIWKLSRRTFNKEDNQRYSSELRYLRERGVA
+LLCGLDIPNLISFGRADGTTWNPMEEMKKDCDLLLPFQVGTGVPDQAENEAHADRLIRHL
+SSRLMYNDKPVVAHAEAVNLNTQGNELNALEITINNIPMPPENIPWEDLIQFRNEEETVA
+KLRALRIWLKDRSSAGQSPREIQEELEHLLYEYRKYMEIQHKKFRQGILSTLISSTPEIV
+ASVATLNFGAAIKSVFDIKGRYLGLSEAELSAPGREVSYIAKARDFLTS*
+>PROKKA_00159 hypothetical protein
+MQDLPVAVKDEEAAHPIAASCRPMLRKVVSAFVRGDYQLSQLIEGVSPVPPDVAAHIQDY
+IAGYGETLVELPEETWSTSCVQWMWSYWDVLVDLYTEREGASDLVLTRRMDEVEGKPQFT
+VGLVYVPKPQPNHAFQFVPWLTATPPDVLKRAAEFRGRL*
+>PROKKA_00160 hypothetical protein
+MNTQKLINRALSGLDDLGYQLDSMGITSKVNRHNVIAYVMAEQKHWEGEYDSLVARIDQQ
+RFRVEQIVGRVEGLVRGGAEFALKPVSGLRSLVKA*
+>PROKKA_00161 Sensor histidine kinase YycG
+VKIHSQLRNSTFQIALLYMVVFATSVFLLLAFIYWRTAGFMTAQTDETIEAEITGLAEQY
+RSRGINGLIAIVRERVARDPNGKSLYLFTTSDYDKLAGNLSAWPQNVQASNGWINFTLND
+SVGWRGEPHLARARVFKVQGGLRLLVGRDVQELTTLKHLIERAIDWGMGITLALSLFGGF
+MISRSTAKRIEVINQTARKIMNGHLSLRIPARGTGDDFDQLADNLNQMLDRIVHLMEGIR
+HVSDSIAHDLRTPLTRLRTQLENTLLTVEGDAARDQVARAVAETDQLLATFNALLRIARL
+EMTGHSADKSPVQLGPLVHDACELYEALAEDKEQEFVLDIPQDVTIEGDRDLIFQVVSNL
+IDNAIKYTPPEGNIRVLVTQEEDDAIFQVEDSGIGVPDSEKDKVFERFYRVAKSRSQPGN
+GLGLSLVSAVVDMHQGRIELADRYTDGRENPGLKVTLRFPRLKPNRRKEIKPTSTTEPEG
+SAS*
+>PROKKA_00162 Transcriptional regulatory protein CusR
+MFGITATEAQSEYEPTEEPQGETKLRVLVIEDDQDVAAYLIKGLKESDYVVDHAADGKTG
+LLMAAGEDYDMMIVDRMLPGMDGLNIIKTVRATGNTTPVLILSALGDVDDRVEGLRGGGD
+DYLTKPFSFTELLARMEVLVRRTRSSNEPETVLKVADLEMDLLARTVKRAGQSIDVQPRE
+FRLLEYLMRHAGQVVTRTMLLEKVWDYHFDPQTNVIDVHISRLRAKIDKGFEKPLLQTVR
+GAGYMLREDT*
+>PROKKA_00163 Hydroxypyruvate isomerase
+MPRLAANLSLLFNEVPFLERFEQAARAGFRAVECQFPYAWAPEAIAAQLQGQGLQQVLFN
+LPAGDWDGGERGIACLPGREADFREGVERALRYAEIMKCRQINCLAGPLPTGAPPEPYWA
+TFEANLRWAAPRLAEQDITLLIEAINSKVDVPGFLLDHSKLALDLIDRLNLPNLKLQYDL
+YHMQIMEGDLLRTLGANLPQIGHIQFADNPGRHEPGTGEINFRRIFEQLDAWGYEGWVAA
+EYVPEVGTFDGLSCLKSWL*
+>PROKKA_00164 2-hydroxy-3-oxopropionate reductase
+MTDLPRIAFLGIGLMGRPMATNLINAGYPVTVWNRSPEKARALAGQAGVAESAAQAVAQA
+DRIITMLENGDAVQQVLVEQGVAEAIQPGAVFLDMSSIAPEMAKSHAGRLKARGVGYIDA
+PVSGGTVGAEQATLSIMAGGSHEDLEAVRPLLETLGRVTHIGPAGSGQLAKLANQAIVGI
+TIGAVSEALLLAAKGGADPEAVREALLGGFAGSRILELHGQRMLARDFEPGAPSRIQLKD
+MRMILDQARAEDLTLPLAQQAFQSYRALIALGEGECDHSALLLQLEHLNQTRMSDPSDGQ
+ER*
+>PROKKA_00165 RNA polymerase sigma factor RpoH
+MGTSLQVMDKLIPGANVQAYIQGVNAIPMLTVEEERELAARLQQDNDLEAARRLVLSHLR
+FVVHIARSYSGYGLAQADLIQEGNVGLMKAVKRFNPDYGVRLVSFAVHWIKAEIHEFILR
+NWRIVKVATTKAQRKLFFNLRSAKKRLAWLNNDEVTAVAADLGVEPRVVREMEGRLAAQD
+TAFDAPTDDDDDNAWQAPAYYLEDRRYDPAQQLEAADWTEDSNSRLLEAMDSLDERSQDI
+LRERWLSESKSTLHELADKYGVSAERIRQLEKNAMKKIRKMMGEESIA*
+>PROKKA_00166 Cell division protein FtsX
+VDESREKSGRRGAGVAENPTRELLDAYASHHRKIARDSLIRLLRNPIGSLMTWLVMGVAL
+ALPLGLMLLLASAQSLGEGWSDSSRINLYLKQNVDETAAMNLQGKLRSRGDVRDVQLVTR
+KQALAQLRKDSGLSAAFDYLNDNPLPNTLIVAPALQDPGAVQSLSQSLKQLPQVAEVQVD
+LAWLKRLRAMIGLVVNAVWALGVLLALAVLLVVGNTIRLAIENRRDEIVVAKLVGGTDAF
+VRRPFLYTGAWYGLGGSIVAIILVALFEAWLDGPVNRLASLYGSHFQLQGAGFGDFLLVI
+MVGVLLGWMGSWLAVKRHLDAIEPR*
+>PROKKA_00167 Cell division ATP-binding protein FtsE
+MIRFEHVTKRYEGGHVALRDVSFALERGEMAFLTGHSGAGKSTLLKLIMLMERASEGQVV
+IGGQVLDKLPRRRIPYIRRHIGVVFQNHQLLFDRTVYDNVALPLEVMGIAPREVGRRVRA
+ALDKVGLLSKERMNPMELSGGEQQRVGIARAVVNKPPLLLADEPTGNLDPELSASIMHLF
+EAFNQVGVTVLVASHDISLIRHLGHRVITLDGGRLAQGDRMPDEEALYG*
+>PROKKA_00168 Signal recognition particle receptor FtsY
+MTAEWISVGLLALLVLAFVIDIGLRLRKPPQKPQPPVAERPPAAPEQREAVPEAKAPPPR
+PEAPAAEEKPAKAEPEAEVVEPEAEAPPAPPVAEEAPPVEAPPAETPAAEPEVEEAPVNW
+FARIKQGLGRTRGNFSEGLSNLLKGQKAIDDELMEDIETLLLTADVGVTATTEIIDTLTE
+KLERKQLKDGDALKQALREELHGILAPSTAPLNIDDGHKPYVILMVGVNGVGKTTTIGKL
+ARRFQDQGKRVMLAAGDTFRAAAVEQLQVWGERNNVPVIAQQTGSDSASVIYDAVQSAQA
+RGFDVVIADTAGRLQNKENLMSELEKVVRVMKKLDPEAPHEVMLVLDAGTGQNALSQAQI
+FQQAVGVSGITLTKLDGTAKGGIIFAIARQLKLPIRYIGVGEQVGDLRPFQAEEFVEALF
+DEPA*
+>PROKKA_00169 Ribosomal RNA small subunit methyltransferase D
+MPPTRRSPPRQQRVTAKKAGGLSRLRIIGGQWRSRQVPFPPVEGLRPTPDRVRETLFNWL
+AGDIPASRCLDLFAGSGALGLEALSREARHLVFVDTASEVIRTLRENLRTLGCQQADVFQ
+QDAEQFLQRPPATPYDVIFLDPPFRQGWLDKVIPLLQQPGWLKPGGWVYVEHEAELNARP
+WPSHWHEHRQKEAGQVVYRLFHVADALKDTAEGVERAS*
+>PROKKA_00170 Lipase 3 precursor
+MHLWRIVWVLIVLVAVLGGVYFLFPGTIVNADKSFELWRAGLAVHDINVDDQHIHYVDSG
+GQGRVVLMLHGFAADYYSWPRMARYMKAGYRVIAPDLPGFGQSSRIAADNYGISQQAQRM
+HDFLRALNVDKVDIVGNSMGGWIAAEFAARFPAQTRTLTLIDTGGITAPHPSPFMQAVEK
+GENPLVVHNRAQFNHLLTIVFHHQPFIPGPLKGYFAKQAVEHAAFNEKVFKDLTDDYVDL
+EPLLPKLTMPTLVMWGRYDQILDPSCVEVLKAGLPNATIKWFDTGHAPMLEQPKASAEVL
+KAFLQANRGD*
+>PROKKA_00171 Fatty acid desaturase
+MWLYGLFHHLPAWQLILIALAMTHVTIVSVTVYLHRHSAHNSVDLNPVVAHFFRLWLWLT
+TGMVTKEWTAIHRKHHATCETEEDPHSPVVKGFSEIMWRGAENYRAAISDEICERYGQRT
+PEDWVERNVYSRYRLGGVALMAVIDLLLFGVNGIWIWAVQMMWIPIFAAGVINGIGHFWG
+YRNFECADNARNIVPWGILIGGEELHNNHHTFPNSSKLSRRWWELDIGWGYIRLLQLFGL
+AKPKGYRPIAHQIPGKMDMDVETVQAIANNRFHVMRLYRKRVLEPVLRQQRSVVEKDIKP
+LYRRVRKLVFREESLIKPQERQSLEQVLQNSAVVRLIYEKSHELQAIWQRRPGMRPQDKL
+NALVEWCHQAEESGVRYLEEFAATLRSYSLRPQTA*
+>PROKKA_00172 hypothetical protein
+MENINRITTGNCSIDPIDNTEPQAYQLRVF*
+>PROKKA_00173 Formamidopyrimidine-DNA glycosylase
+VPELPEVETTRRGIEPHLVGHTVTQLQVRESRLRWPVPDKLDQMLPGQKVGQVARRGKYL
+LVHLERGTLLVHLGMSGSLRVVTRAEALRKHDHIDLTTDAGTIIRFNDPRRFGAWLWTED
+WQHHPLLASLGPEPLSPAFSGHYLHRQSRRRKAPIKQFIMDSHMVVGVGNIYANEALFIS
+GIDPRRPAGRISAARMEALVLAIQQVLENAIAVGGTTLRDFVNSEGQPGYFRQSLQVYGR
+EGQPCRRCGKPLRQLRLGQRSTVFCGHCQR*
+>PROKKA_00174 hypothetical protein
+MRPKLSHALAAILAACVMSLAPMTQAETTQSTPSALAMTGDALFARPALLAMTLVGSAVY
+VVSLPFSLLGGNASEAGKVLVVDPAKATFTRCLGCTMNQNRQNEQKNQNQVATADNTDTT
+SN*
+>PROKKA_00175 GMP/IMP nucleotidase YrfG
+VLACFYFFADSPMLNWSQIDTALLDMDGTLLDLHFDSHFWLEHLPRRYAELKHLDPEHAR
+QSLLSKIEQLRGKLDWYCIDFWSDLLDLDVVALKRETRDRIAWRPHSKAFLERLRACGIR
+RVLVTNSHPDGLNLKIETTGIDQHLDRLFSSHSFGQPKEGPDFWEQLAQQEPFDPERTLL
+IDDSLPVLESARRYGIRHLLAILSPDSQQPPRQPSHHPCVHDFDELFQSLDQFAHQKNRI
+DGLSD*
+>PROKKA_00176 Heat shock protein 15
+MTAHSDQQQQEARIRLDKWLWAARFYKTRTLAKEAIEGGKVHYNGQRTKPGKVVELGARI
+RLKQGWAEKEVVIQGLSDRRGGAPQARELYQETDDSQQRREDEHWQRKMMQAAQMPPARR
+PNKKQRRELQRLKSGQG*
+>PROKKA_00177 33 kDa chaperonin
+MTGQDQLQRFLFENSNIRGSIVRLDDTFQQATGQQDYPTVVRNLVGQSLAACALMGDSLK
+FQGSLSLQAQGEGPLRLLVSDSTDQLTLRGLAHWNPEAAEAETLPALIGNGHLVITITPD
+AGQRYQGIVPLEQDTLAGCLEDYFRLSEQLATFMCLFADEKGAAGLLLQQLPGELAGPDT
+DLWPRAIKLAQTLTTEEALQLPSEELIHRLYHQEQVRLFPARATRFGCSCSRERTRLALE
+SLGQDDCMALLDEQEVIEIDCHFCGQRYRYDRADVRAVFGGPRLH*
+>PROKKA_00178 Phosphoenolpyruvate carboxykinase [ATP]
+VSNTYTDLSSARLVELALERNEGKLAANGALVVNTGRRTGRSPMDRFIVEDPATAELIHW
+GPVNRPFDAAKFDALWERVESHLEERDQFVSYVHVGADPEHYLPVKMTTETAWQNLFGRN
+LFIRPDNYNPIDKGEWQILNAAGFVCEPERDGTNSDGCVILNFAERKVLIAGMRYAGEMK
+KAMFSVQNFLLPEQDVLPMHCSANVGEDGDTCLFFGLSGTGKTTLSADEDRYLIGDDEHG
+WGRGTVFNLEGGCYAKCINLSKKNEPIIWDAIRFGAIVENVVIDNDSREPDYDDVSLTEN
+SRCAYPLEHVEKRVLENRGGEPRAVIFLTCDMTGVLPPVSILNKEGAAYHFLSGYTALVG
+STEMGSSAKLRSTFSTCFGAPFFPRPAGVYANLLMKRMEEFGSRVYLVNTGWTGGPYGVG
+KRFSIPTTRAIIRGIQTGALENVQTQHLDDLNLDVPVEVPGVDSNLLNPRNTWQDKEAYH
+HKAQELIAQFVENFKKFDVSDAIVNAGPKLKD*
+>PROKKA_00179 DctM-like transporters
+MSEAIEQSSMYLQKRTIGGRSAREWFSSLPACILLMAVVLFTTSSDIHNKALQLGQVLWS
+GYYKLRVDPVKPDCNPNVNVDAQVKRQIAAQAAQQDSMLGSLVGSSPVNPAAVRQSVINA
+KQACEAQFADYNATKGRITEGVRVYRSVELFISDVVAFGLASQRYILALLVLVCAATATF
+SRHHIAMRGMETRLDHIVSHFMQFIANTMLLISSFMYRQMSHNSGAVVTTGQEISHDIWI
+AGFLLLTIVSLVQLFRVPEDAEEGGTLGHAFLCVPLYTTMCLISGTFFAFVGSPAGIGIY
+LDKMMELADQFLNVGLYVWAGMMLKQTRLASLVFNVLRPLKLPPELLAVVAVMVAAVPTA
+YTGASGIFVIAAGAVIYSEMRKAGARRQLALASTAMSGSLGVVLNPCLLVVVIAYLNREV
+TTDSLFHWGGWVFLLTSTLFLITSLVVNRQKGFKVAPMNEALPEMVMRLKPLIPYVLVIA
+GVVFFYWLLLGVTMNEFSAPRILPIIMVGILVYEHVHFRGDRNKVSGEVDHQGLEKSLRT
+ATSETTAEIGALLLLFGLSVSIGGVIERSQVMSLFPQALPSPWLAMMLMVVILVILGMIM
+DPFGAVILVSATIADLAYQSGIAPVHFWMVTLVAFELGYLSPPVALNHLLTRQVVGESEM
+NLSYRESGSFYQRHERVLMPLLVMGSALLIVAFVPLLFYAR*
+>PROKKA_00180 hypothetical protein
+VKPSGKRFSLKTWSLASLTLAGMLALQPAANAGSLPKRSFCVFDPVGANGPLFNLMKSTK
+PAALDWGVDLQMRAYTDEKIAAEDFKGGQCDSVLLTGTRAREFNKFTGTLEALGAITSNK
+EERVLMDTLNQPKAAKLLTNGDYEVAGILPAGAVYLFTRNRNIDTVNKLQGKKIATLSYD
+RASLTMVRHVGASVVGASSASFAGLFNNGSVDLAYAPAVAYTPLELYKGLSHDGGVLQYP
+LAQMNFQIILHKSRFPKGYANHVREYAREHLNQAFSIINKATDEIKKKYWMYPTDKQTAS
+YDQMLQSVRLSLRDKGVYDAKALKLMKIIRCKVQPSRGECSQNAE*
+>PROKKA_00181 hypothetical protein
+MRWLSHSAFLFSHGRSAVKALSLLLLFSLGGCSAVNNMMYKTTGEVMVGYAKAHAVPYVL
+SSDDLGMSCAMSEALTPLLMSFGQVTAKPDQLGVMMQMSAGTCAEEKGWNAELAYMKELR
+NQHPQNAEDDMIVEKRHYIEAADRYYSAWKHLVAYYGDPSTGQCPTFKNDEGQFIYMAGL
+LAGVQALAAEIQSTSDEGVPKNIGSTVAQASGCLSDDKWWGVPMALRATVWSMIPGAKPD
+GENPFQRLDESDKKANKARVRLAYVLHVIAAWNKGDTKLVKKLIREQQAQEAKYPADPRW
+KMIDKLSTLYLRSISDRMWVEHTGHRTPIGGLGTFWDDSKGSGEVIDLDSVM*
+>PROKKA_00182 DNA-binding protein HU
+LENSTQNALHKPELAGKIADQTQLTRAQAHEVITAFTDQVSAAMARGETVALAGFGSFNV
+RERQARTGRNPRTGEALQIPAHKTVGFRPGKAFREAIE*
+>PROKKA_00183 hypothetical protein
+MSFLIFVALLVALWLLWTISRNTADALDKQTAVQYEIIALEKRMEELSEALKAQSGETAK
+PARRSSSSRSKKEDEKEKKEGE*
+>PROKKA_00184 Dihydroorotase
+MKLLIQNGQLLDSRTGQVRSGAVLIEDQKIVAVGEQVLDQAADRVFDADGAWISPGFIDL
+CCFVREPGDDQKGTLASETRAAAHGGFTTVCASPESSPVNDSGAVTTLILERARKQGCVR
+VLPVGALTRGLQGELLSDMASLARAGCVALSNGSLSRGNARVLRRCMAYAKTFGLTLFMR
+PENPDLAADGYAHEGVVATRLGLPGIPEIAETIAVGELIQLAEDTGVRLHLSQLSAARSV
+ALLRSARERGVPVTADVAIQQLAFNEGWLADFDSRFHCRPPLRTEADRQGLLAAVNEGWI
+DAIVSQHQPHDPAAKQAPFGETEPGLSTVESLLGLGLKLVNAGELELPRFLQALTLGPAQ
+VLNLPEPRLEAGSRADLTLFNPNGQWIPAPETLLSAGKHAPVLDQPLPGRVMLTLSRGKV
+AYADPQTEFGL*
+>PROKKA_00185 Aspartate carbamoyltransferase
+MIDTCEAARQLQLNAAGSLRHFLTLDGLDRPLLTEILDTADSFIEVGERRIKKVPLLRGR
+TVVNLFFEASTRTRSTFELAAKRLSADVLNLNISTSAASKGESLSDTLLNLEAMASDMFV
+VRHAQSGAPHFIARHVTPGVGIVNAGDGRHAHPTQAMLDMLTIRQHKGGFEGRVVAIVGD
+ILHSRVARSQIRALEILGADEIRVIGPNTLLPRDVESLGVKVFNDMQRGLKDVDVVIMLR
+LQNERMEGALLPGEREFYRLYGLTTEKLRYAKPDAIVMHPGPINRGVEIESAVADSPRSV
+ILNQVTNGIAVRMAVMSMVMSGQLAQLNQGDAAQEQSRTL*
+>PROKKA_00186 Bifunctional protein PyrR
+MTAQINVERLLETMCSQLEQTLEARGAVNPVLTGIRTGGVWLADYLHKRLRLEEPLGELD
+ISFYRDDFSRIGLNPRVKPSNLPFATEDRHIILVDDVIMSGRTIRAAMNELFDYGRPASI
+ILVTLLDLGARELPIQPDIVGQQMQLQRDQRVKLMGPDPLRVELRENVRENPAKDASTKS
+H*
+>PROKKA_00187 Putative Holliday junction resolvase
+MPDLKPEGQRQVMAFDFGLRRIGVAVGQEMLGTASPVTMIGARDGIPRWDEVEALIADWK
+PDFFVVGLPLNMDGSESEMCRRARKFARRLHGMYHRDYAMMDERLTSFAAKSAIVEREGG
+RDFGVKGVDDLAAVLILEGWFLQQRDQQPKIPTP*
+>PROKKA_00188 hypothetical protein
+MSEANPYIRNQFLIAMPYMQDPNFNGTLTYICDHNDQGALGLVVNRPLDFSLGEILEQLD
+IECGHLDVPVYSGGPVKVERGFVLHRSRGEWQSTLEISGDLSVTTSRDVLEAIAEETGPE
+DYLVALGYAGWGAGQLEQELAGNFWLTCPADPDILFNVPWQQRLPAALARLGIDWSQLSD
+SVGHA*
+>PROKKA_00189 transport protein TonB
+MAASAVRVSDTDRLTFTLFLALVLHAIVVLGVTFTAHKPQPSARTLDITLAQRDDQKAPK
+HADYLAQTNQKGSGTLSKKAQITTRHRAPINASQVHKVKPIPRSQPQHSQAKPEKRHVVT
+TVSQQATQQVDSDDKEQKAHQKHNHKSLMSRALEIASLEAKLDQETQRYAKRPRVLRVTA
+ASTLKSTDAWYVQAWVNKVTRIGNLNYPEAARRRGIHGTLRLLVDILPNGHVKDIQVLQS
+SGYKVLDQAAMRIVRLAAPFAPFPPELRKRKDVLEIIRDWSFEPRGLSTNG*
+>PROKKA_00190 Glutathione synthetase
+MSVKLGIVMDPIGAIHYKKDTSLAMLLAAQRRGWELHYMEMQDLYLRDGEPRARTQALTV
+AANPDDWYSLGEPSDRALASLDVILMRKDPPVDKEFLVTTWMLEAAERLGTLVVNPPQAL
+RDCNEKLFATWFPQCTPPLVVSRDAARLRAFHAEHGDVVLKPLDEMGGRSIFRVREDGDN
+LGVIIETLTKDGSHQIMAQKYLPEITQGDKRILLVDGEPVPYALARIPSQGEHRGNLAAG
+GRGEGRLLTDRDRWIVEQVQPMVREKGLLFVGLDVIGDYLTEINVTSPTCVRELDREYDL
+DISDQLMQVIADRLARR*
+>PROKKA_00191 Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
+MEDNFENLKIMVIDDSKTIRRTAETLLKKVGCEVITATDGFDALAKIADSHPDIIFVDIM
+MPRLDGYQTCALIKNNSAFKSTPVIMLSSKDGLFDKAKGRIVGSDQYLTKPFSKDELLNT
+IRQHIPSREST*
+>PROKKA_00192 Response regulator PleD
+MARILIVDDSPTEVKKISSLLEKHNHEVLTADNGADGVAKARAESPDLVLMDVVMPGLNG
+FQATRQLTRSPDTADIPVVIVTTKDQETDRVWGTRQGAKGYLVKPVKEDELIKTIDDLLA
+*
+>PROKKA_00193 CheW-like domain protein
+MSAQAAPFAVLSDIATRSRSQSRGLPAQEEAVELWNGIGFSLAGQLYVAPMGEVVEILHL
+PRYTQVPGVRAFMVGVSNVRGRLLPLVDLGLFLDFPRSVV*
+>PROKKA_00194 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00195 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00196 hypothetical protein
+MSKPKYPFEKRLEVVNHYFTTDDGYRIISARFGVPRTQVRTWVALYEKHGEKGLIPKPKG
+VSADPELRIKVVKAVIEQHMSLNQAAAHFMLAGSGSVARWLKVYEERGEAGLRALKIGTK
+RNIAISVDPEKAASALELSKDRRIEDLERQVRFLETRLMYLKKLKALAHPTKK*
+>PROKKA_00197 Integrase core domain protein
+MNMVENMLDQAFKKLNPHEHPVLHSDQGWQYRMRRYQNILKEHGIKQSMSRKGNCLDNAV
+VECFFGTLKSECFYLDEFSNISELKDAVTEYIEYYNSRRISLKLKGLTPIEYRNQTYMPR
+V*
+>PROKKA_00198 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00199 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00200 High-affinity branched-chain amino acid transport system permease protein LivH
+VIAWVVLLALWLFVTRSRPGKAMLAASMSRTGLALVGYDIGKVYLQVWGLYGLLAGIAGV
+LLASFTGASASIAISLTVNAFIIVVLGGLGNVAGSLGAAYIIGLLGTLTAYLISPSVREI
+PGLLVLILILYVRPQGLFGRH*
+>PROKKA_00201 leucine/isoleucine/valine transporter permease subunit
+MASRIHWDWRAGLVLLALIVLAFLPFGVSGYILGVMTVAFYLAVYAMSWDLLFGYAGEVN
+FGPTFLVGLGAYGAGLSNSVFNISVWPSVAIGTLAAVIGGLVLAGPALRLRGPYFGLVTL
+VAVILLEKVIGLLSSYTGGEIGLTVMDVLTISQSGNYYYAFGFMVISAVILRIIARSSIG
+LILEASGQDPVATEALGFNVTKFKFMAFTLSAFFSGLAGALTVFYLGSASPGTVVSVFVT
+IQIIIATLVGGRRSIIGPILGAVFLIAAGEILRPLGQLSNAVVALIALLVVLFAPNGFIG
+LFSRTGGAR*
+>PROKKA_00202 High-affinity branched-chain amino acid transport ATP-binding protein LivF
+MSVLKAQGLYKRFGGLQAVNNVSFSVDRGEVLGLIGPNGSGKSTTLSLLMGVTRPDRGSV
+QLDGQEMAGWRTHRIAKQGLSMVFQHSRPLHRQTVLENIKLALLPDTLWQLFPPHTLDRR
+AREIAERVGLHNVIDTLPGNLPFADLRRLEIAKALAQDPSVLLLDEPFAGLSPRETREFA
+ELVHLFREEGRAVILVDHNVKEVAGLVDRIVAMHAGQVIAEGTPDEVTRDPKVREVYFGQ
+SLENASGIHADGDRRSEGNGSEALLEIDLRSVRYGLAEALRDIQIQINQGECVSVVGING
+AGKTTLFKSILDFQGYEGDVRWQGTSLTGQGPGQVASQGIALCPESRELFGFMTVRENLE
+LGGHKLDRQAHESQMDRVFDLFPVLRQRQAQAAYTLSGGEQQQLTIGRALMQQPKLLILD
+EPTLGLAPLVIENISEALHKLQQDSGMTLLLGEQNLTFALRHSQRIYLLETGNLRWHGPA
+ERFIEEVGEDVL*
+>PROKKA_00203 hypothetical protein
+MFCNGNQGYDFSINSHPGHAHQMQRRSHATNSQSGPVP*
+>PROKKA_00204 Putative alcohol dehydrogenase D
+MQRTARAALCREWNGPIQVETIRVDPPRRNEITIKLRACGVCHSDLSAATGVIPFPPPLV
+LGHEGAGTVIAVGEGVTDFQEGDHVVSSFIYMCGKCRQCSRGRPVLCEQAHKALHHLPDG
+TVRTHDGDGNPLNVFGACGVMAEYATLHVNNAVKIDPDVPLERAALVGCAVMTGAGSVFN
+TAQLEPGSTAAVFGVGGVGLNAIQGCAIAGARVIVAVDTNEEKLAMARQFGATHTVNARE
+HDDAGKAVKKMTGGGDYAFECVGSGVTVAQAYGSLGRGGTAVVVGVADVKDKTTFRTLSL
+PADERTLKGSWLGSARPQFDFPRLLGLYQGGRLKLDELVTHTYTIDEAPQAFEDLKAGRN
+ARGVILFD*
+>PROKKA_00205 3-succinoylsemialdehyde-pyridine dehydrogenase
+MTIKSYDSVYFDGRWQPVDGERLSVYESGTGEVMASIPGAAPAVMQQAIDAAHNAFDSWS
+RRPLKERLKYIEALHGQLVARAEEIATTISREVGMPLKLSRNIQAGLPIAITDSYLKLLP
+DFPFEEKVGSSLVQYTPVGVVGCITPWNYPLHQVILKVVPALAAGCTVVLKPSEVSPLSA
+FMLAEMFDAIDLPPGVFNLVSGLGHVVGDSLTGSNKVRMLSFTGSPGTGRRIFHAAAEDF
+KRLALEMGGKSASVILPDADLATAVKGSVNNCYLNSGQTCIAWTRMLVPADKHDEACELA
+VAAAKKLTLGDPLDENTRLGPLASKEQLERVRNYIRVGIEEGAKLMTGGPDAPAGLDKGY
+FVEPTIFANVDPQSRIAQEEIFGPVLCIIPYRDEEEAIAIANGTPYGLSGGVWSADQDHA
+IAVASRLRTGQVTVNGGAFNPEAPFGGFGASGLGREFGRWGLEEFLEVRSLQL*
+>PROKKA_00206 hypothetical protein
+MLRFIVALMLLFPLVAQAEDAIKPGQWKQTIHVTIPGSSVKIPPHSSTNCVKPEQAGSIK
+SIIEEAQQPGCKLNEYSRSGNKVHWKMTCTGKSQASTEGVFTLQSKTSYHIHMNALMQTP
+NGPYKTVVDSDGKWVGPCK*
+>PROKKA_00207 Long-chain-fatty-acid--CoA ligase
+MRAPDELINGRWASEITAALPARIHQGVAQHWEADPEAEALVDHQVRWSYRELSAAVAAA
+RQWLVGQGVRPGDRLMLVSENGRALVALLLAASGLDAWAAIINARLADNEIDAIRDNCDP
+RLLIYTTEVSPDARNHAQRHDADIVHLDPLGEFAVGPAAAQSLPQPVVKDGTQVAAMIYT
+SGTTGQPKGVMLTHRAILFIARVSGGLRNLRPGRHVYGVLPSSHVFGLSSVMLGSLANGA
+CLHTVPRFEAGALLDALAGERISVLQGVPAMYARTLEYLHQHNRKLVAPALDYLSAGGAP
+LDTDLKTRVEATFGTTLHNGYGLTEASPTISQTRIGEDSEASSVGRILPGLDYEVVHLKS
+RQPVLQGEVGELRVRGPSIMRGYFRKPEATRAVLDDAGWLDTGDLARIDPDGQLHIVGRA
+KELIIRSGFNVYPPDVEAVLNEHPAVTLSAVVGRQITGNEEVVAYVQLAPGHDMTESALS
+EFAAARLSAYKRPSEIHILDQLPVTPAGKILKARLRALANQTPDR*
+>PROKKA_00208 Acyl-CoA dehydrogenase
+VIRDKETLNQLIDTISRFVRERLVPSEEQVAQDDAIPEDILQEMKDMGLFGLSIPEEYGG
+LGLTMEEEALVAMEIGRTSPAFRSIFGTNNGIGSQGILIDGTDEQKRRYIPRLATGELIS
+SFCLTEPDVGSDAGSLRTTATRDGDHYVLNGTKRYITNGPEAGLFTVMARTDPDNKGAGG
+ITAFIVEGDTPGLHRGRPDRKMGQKGAHTCDIIFDNCRVPAENIIGGREGVGFKTAMKVL
+DRGRLHISGVCVGVAERVLDDALHFAMERTQFGKPIAEHQLIQALLADSKSEAYAGRCMV
+LDAARRKDAGENVSTLASCAKLFCSEMVGRVADRAVQVHGGAGYMAEYAVERFYRDVRLF
+RIYEGTSQIQQLVIARNMVREAD*
+>PROKKA_00209 Pca regulon regulatory protein
+VVDDNSDLGLDAALDPQNGAKDRKFVTALARGLEVLRAFRPGDGFLGNQEIARRTGLPKP
+TVTRLTYTLTKLGYLSYSQRLERYSLGTGALALGYATLSTFGIRQIARPLMQELADDVDA
+SVSLGARERLSMIYLENCRGSGAVTLRLDVGSRIPIATTAVGRAFLAALPEGERNYLMDH
+IKRHAGNRWPPVRRGIERAIRQYQETGFVKTVGTWERDVNAVGVPLVQSDNGNIYAFNCG
+GPSFVLPEERLDAELGPKLKQLVQNVEAALRRL*
+>PROKKA_00210 Beta-ketoadipyl-CoA thiolase
+MLDAYLYDGLRSPFGRHAGALSPLRPDDLLATVIQALIARSGFAKEQIEDIVIGCTNQAG
+EDARNVARHAGLLAGLPVETAALTVNRLCGSGLAAVADAARMITCGEGELILAGGVESMS
+RAPFVMAKAESAYSRQLRTFDSTIGARFPNPKVLAEFGSDTMPETADNVARDLGISREAA
+DAYALQSQQRYEAARQDGFYREEVLPVEVPQGRKQPPRWVSADEHPRPDTDTAKLARLSP
+LFEEGVVTAGNASGINDGAAALLIGSRSVGQRLDIKPRARILSAAAAGVPPRVMGLGPVP
+AAQKALARAGLSLNDMDIIEINEAFAAQVLGCCQQLGIAGDDPRLNPNGGAIAVGHPLGA
+SGARLTLTAMRQLERINGRYALVSLCIGVGQGVAAVIERM*
+>PROKKA_00211 Acyl-CoA dehydrogenase
+MKPFTWEDPLLLDLALDSDERMVRDSAHDYCQNKLMPRVLEANRHEVFHREIMNEMGELG
+FLGPTIPEQYGGAGVNHVCYGLIAREVERVDSSYRSAMSVQSSLVMHPIYSFGSETVKQK
+YLPKLASGEWIGCFGLTEPDHGSDPGSMITRAKKVDGGYRLSGAKTWITNSPLADVLVIW
+AKLDDTITGFVLERGMEGLETPKIEGKFSLRASVTGQIMMDDVFVPEENRLDVTGLKGPF
+SCLNKARYGISWGSMGAAEFCWHAARQYTLDRKQFNRPLAANQLIQKKLADMQTEITLGL
+HGALRLGRLMDSGDWAPEMVSLLKRNNCGKALDIARTARDMHGGNGIADEYHVIRHVMNL
+EAVNTYEGTHDVHALILGRAQTGLQAFTG*
+>PROKKA_00212 Acetolactate synthase large subunit IlvG
+MVERKHGGLIVAEHLQAAGISHLFALCGGHISPILVQAKALGIEVVDVRHEASAVFAADA
+MARLTGRPGVAAVTAGPGVTNTITALKNAQMAQSPVVVIGGATPTVLKNRGSLQDIDQLA
+LMKSLVKWQTSVGTLAQLDEAMRYALEVAAQGVPGPVFVEAPIDLLYPRDLVHSLYADQA
+GLDKMKGPVGRLLRGGLDLYLLRQERQPALSVHPNLKTLTEPAAEWHAARQLGEVVKRLA
+SAQRPALVLGSQVLVNRTAEQAKDIADAVERLGLPVWTGGMSRGLLGAEHDLLFRHHRGR
+ALAEADLVIVCGFPLDFRLKYGRGFAKGATLVSVNLSLHDLLLNRKPTVPVLAHPGDFLQ
+ALADRMSSRAAQWRAWLGELGKRENAREEEIDQQAAAPADKVNPLHFFRTLDRHLGEQDV
+LVVDGGDFVATGAYTLKPRGPLAWLDPGVYGTLGVGGGFTLGAAAARPGSRIWLIYGDGS
+SAYSLAEFDTYRRLGLAPIAIIGCDASWRQIAREQVEMLGDPVGTDLRDTDYHLVAEGYG
+GHGILVEHNHQIDAALAEAIKLSDAGTAVCINLRLAVSEFRKGSISM*
+>PROKKA_00213 Esterase EstB
+MGRSDVIAGLSLERLDNIERHIDRKYLKPKRLPGTLTLVARRGQVAYVKAQGLMDVERNK
+PVARDTIFRIYSMTKPVTSIAMMQLFEQGRFLLNDPVHKYIPAWKNLRVYQSGVYPQFLT
+TPTLRAMTIRDLFTHMSGLTYGFMCRTNLDAAYRELKLDGGKEMTLDLLVERLSQLPLEF
+SPGSAWNYSVATDVLGYLVQLLSDRPLDEYFREHIFDPLEMADTGFMVPESKRERFAACY
+QFDPEQGYALQDDPADSHFTRPIKFLSGGGGLVSTVDDYYRFAQALNNGGQLNGARIIGR
+KTLDFMTMNHLPGNQDLPGLSIGPFSETPYEGSGFGLGFSVKVDVAKSQTNGSVGEYGWG
+GLASTNFLVDPVEDLIMVFMTQLIPSSTYPIRQELRSIINGAIVD*
+>PROKKA_00214 Long-chain-fatty-acid--CoA ligase
+MHGLMMNRQLLISQILEYAAVNYPEQEIVSRTTEGPIHRYRYPELRDRSCQLAHALAGLG
+VTQDDRVATVAWNNYRHLEIYYAVSGMGAICHTINPRLPAEQFQFIVDHAQDQYLFVDLT
+FVPLLEKLHPQLNSIKGYIIMTDEAHMPETGLPNAHCYETLIKDQPTRYDWPEFDENQAS
+SLCYTSGTTGNPKGVLYSHRSTLLHAFSVMAFPGVDFGEESSLLPVVPMFHVNAWGMPYF
+ALITGSKLVFPGPRLDGASLAELINSEGVTDAWGVPTVWLGLLRHMNESGERFSKLEHVQ
+IGGSAAPRAMINEFQERYGVEAIQGWGMTEMSPVGSVSQPTPFMRERMSAEEQLTVRGKQ
+GRALFGVEMKIVDADGKALPRDGKARGELLVRGPAITSGYYRNDEANAKAFDDEGWFRTG
+DVATIDPDGYMEIVDRVKDVIKSGGEWISSIDLENEAVGHPEVAEAAVIGVRHSKWAERP
+LLVVVRNPDSAVTAEAIVEYLSERVPKWWLPNDVVFVDELPHSATGKLQKTKLRDDFKDH
+RFSDDEA*
+>PROKKA_00215 Esterase YdiI
+MTQNPDQKAPIWKRPATVEALNAHAKNTMVEHLAIEYLELGPDFLRARMPVDKRTHQPFG
+LLHGGASVALAETLGSVGANLCIADPDKAGVGLEINANHIRSARSGWVYGTARPFHIGGA
+TQVWEIRIQDEQDRLICISRITMAIVSAR*
+>PROKKA_00216 1-deoxy-11-beta-hydroxypentalenate dehydrogenase
+MKQMQNRVAVITGAASGFGLEFARVGAARGMKLVLADVQAEPLEQARAEMEAAGAEVLAM
+LCDVRKSEQVQALADKTMERFGTVHLVFNNAGVGSGGLVWENTEQDWEWVLGVNLWGVIH
+GVRIFTPLMLEAARRETDYEGHIVNTASMAGLLCPPTMAVYNVSKHAVVALSETLYQDLK
+LVNAPISASVLCPYFVPTGISDSHRNRPAELQNDSGPTASQMIAQAMSQKAVSSGKVSAA
+EVAQRTFEAIGEDRFYIYSHPEALGNVKHRMEDIVAGRNPGDPFAEAPQIGQMLRDKLQG
+*
+>PROKKA_00217 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase
+MGELVDVYRNSVQTWECDQMGHMNVQFYLDKADAGLLALTRMLGLNRRFLNERQARVRVL
+ENHVRFLREQHAGSPLTLRAGLIDIRPDQLKLYFELTNPIQQAVAASFITQAVLESTAGK
+DHLTLPQSALEKAQQYQIDWPRPEGPMGLESTPPRTPPTLQEADDLGMMPTYLGAVSAGM
+CDADGHLAIRSYMGIVSDAVPHLLSRIRHDTREVPRPGGAALEYRWIYHQRPEQGDLVTL
+RSAITHLGNKAYRLGHWLFDAETGHCLATTEAVAVMMDLDERKALVIPQTARASLEEMLV
+KGFSI*
+>PROKKA_00218 hypothetical protein
+MKAGMVAPLDATQQSRLRVLLALFGLVWLINAGFQAVAWLAAPNASTHFIHALAKSTTVV
+PRWVQPLLMTGLHSAQSLGLGIVAAIMVLLAILLGLALLTQRKVAFAARVGIIYSIICWI
+FLDGFGFPYANGQTDPGVFVAYAIAFLFVLSVAPVFDREGTKAPEIDERLWHWARIAFGL
+LWLFDAVLKWIPPFLLHFSSQITSVIPGQPHWIAAWLSFVAELVHAIGPIPVAVVVALAE
+TAIAIGLLSGRWMRLVIPVGMLYSVAVWTTAEAFGGPYSTAGTGVRGNVLGNVLIYLIPF
+LFLWVGNSSQRSAAETTGRTLTD*
+>PROKKA_00219 Pca regulon regulatory protein
+MVKKAPEVDVPSAKDRNFVTALARGLELLRAFGPEDDYLGNAELAERTGIPRPTVSRLTY
+TLIELGYLRYCERLEKYRLGAGVLALGYRYLSRMGLRELARGPMQALADRTDCLVALGTA
+DRLDMTYVETCQGAGPLVLRLEVGSRIPMATSAMGRAYLAALPDARRNEYREKIREVYTD
+DYEAIWQGVEQGVEQYQKLGFCTALSDWNPHIAGVGVPLVLDGGSQIMAFNCGGAAMRLS
+RSVLEKKLGPQLVEVVAEVQRQMHGRRLEAVS*
+>PROKKA_00220 hypothetical protein
+MQRRYLATLLAGLMAVPAVAVADSGSSSSMPDMNIKLHAHLHGSVDFSNTGGRAVPNTEA
+YGEAAGTPARATNLSNNNSTIGFTGQHLVPGAFMAIFQVELALPGSETGVNNSYGKGNHV
+SKNVGLHDTYFGIANPLGTLLFQPSFENQGAYLSRPFNMFKDTVGDFNSIIDTANFPNGG
+PNGLPAISFAGQANYAISYASPKVKGFDAVLSYTEDANGGDFGTNNTYGSGYCAGTPNTN
+HYPNCYGYPNANQHNNAWSFGVQYENEFSSLQSKVNGLINYSQINVQGNTSGVPLGGFTF
+ADATQPNQTPPSSKLQLKALELAGKWDYEPTGTTAIAVWERSTGLYSRDAYSLGFSQAVP
+GNNDLMVSWIHAGNLSSPLANICDPTKTVCSGSEVKQSGANEYVAGIKHHFDKQVSAYLI
+YAYTRNNAEGLYGLGGPNHGQSVYPLNPGDNPQSLSLGMTWDF*
+>PROKKA_00221 Long-chain-fatty-acid--CoA ligase
+MFDRHHQVWPEFAPLHLTLPETSICYNLEVTAHRYPHKDAIIFYDRRISYGEFQRQVEIL
+AGFLAREMGVEKGDRVLLYMQNSPQWMIAYYAILRANAVVVPVNPMNRRGELEHYASDTQ
+ARVILCAQELFDQVSPLLGEEGLSRAVVAAYSEYLPDQTDLPLPDAVSEPARAINQSGVV
+PWRQALAGEPAAPKALVGPEDHCVFPYTSGTTGAPKGCIHTHQSVMATLVGAVAWNPATA
+DSVTLVSLPLFHVTGMQVSMNAPIFVGATMVIMTRWDRRVAGALIERYGVTEWRNIVTMV
+IDFLSDPEARNYDLSSLRAIGGGGAAMPKAIAERLHEMTGLTYIEGYGLSETIAATHVNP
+VDNPRAQCLGIPVFDVDCRVLDVASGQQQDVGEVGEIVINGPQVFKGYWNRPQATAEAFT
+EVDGKSFFRTGDLGYYDEQGYFYLVDRVKRMINASGYKVWPAEVESMMYQHPAIRESCVI
+SAPDERRGETVKAVVVLTDDAPADVTEAAIQQWCQDNMAAYKVPRIIEFRDSLPRSATGK
+IQWRVLQEEERERAAG*
+>PROKKA_00222 Phosphate transport system permease protein PstA
+MQYSSDEISNSGLDRPRAGGYRLRLALSGLGWGSTALMFALLALALIAIIAFVVIRGGAH
+VNWATLSQTTQGYHGLLNAIEGTLLVTVGSLLIAAPVGVVTGIYLSEYQHRRSARFFSFL
+CDVMIGVPSIVLGMFGYIAMVNFFGWQFSLLAGCITLSFMIMPYIARTSELALLQVPNSV
+REAAYALGAGDRVVIFRVVLASCVPQILNGLLFAAAISMGETAPLIYTLGWSNYMWGGEF
+FHHPVGYLTYVIWSFISEPSSAAHQLAYVAALLTTGFALLINILARSTIRKQSQHQSQ*
+>PROKKA_00223 Phosphate transport system permease protein PstC
+MKTNRLFRWSITGIASVIPLALLAIFIFLLINSWPAIKFSGWHFLTGSQWSLGNEYGDLV
+TVNGQEVPPGADYGIGFLIAGTLLSSFLALLIALPISVAASAFLAEAVPKRLQNTLALFV
+ELLAGVPSVVFGLWGLVVLVPFMNHYIYPGLVHVLGDVPFFQPPTGAGYGLLTSSVVLAV
+MIAPLITSTVRGAIERVPMVQREAGLALGATRFEVLWKTVLPSVRRVVIGAGILALGRAL
+GETMAVLMVSGNALGYLPHNIYSPISTMAAFIVSQLDSALEDASGMATHALSEIALILFF
+ITLIVNVIARLLLWLARD*
+>PROKKA_00224 Phosphate-binding protein PstS 1 precursor
+MKGKFSLKSTRTGSMMAKGALAAALLTAGMGVANASTTLQETGSSLLYPLFNQWIPAYSK
+AHSDIQVNAASTGSGTGIAQSIAGNVQMGGSDAYLSGAMMKKHSDMLNIPVAISSQMVNY
+NVPGLNDKHLKLSGPVLSRIYEGTVKYWDNKEIKAMNPGVDLPHHRIVPVHRSDGSGDTF
+LFTQYLSFSHPYWHKKLGYGTTVNWPAVQGEIGATGNPGMVQALKDNPYSVAYIGVSYKG
+QIDKDNLGEAMLKNKAGNFVLPNSTTVPAAAAAMVPKTPKDERISLIFAPGAKSYPIINY
+EYVIMHANQGDLAAPLKQFLNWAVSPNGGNASQYLGAVNFMPLPKKAEELTKAQIAKIHS
+*
+>PROKKA_00225 Transposase DDE domain protein
+MGTTFRPYSPDQELLLPPSLNEWLPEGHLAYFVSDVVEELDLSALYARYDGDGRRNSPFD
+PRMMLKVLIYAYATGTFSSRKIARKLEEDVAFRVLAAGNFPRHRTICDFRKQHLAAFKAV
+FIQVVRIAQEAELITLGTLAIDGTKVRANASKHKAMSYGRMQEEEKRLSKEVDELCRQAR
+RTDEEEDQQFGPDQRGDELPEELQHRQARLDKIRAAKEKLEADQKERDKARGRSPDDDRR
+SPRGGRNFKRDYGVPDDKDQSNFTDPQSRIMKTSDGFQQCYNGQLAVDGEFQLIVANHQG
+SNPSDNGCLLPLLNDVKDTLGTYPRQCLADAGYRKEGDLQTLEVNGIDGYVSLRREGRKP
+GEIDATRYPATARMAEKLATAAGRSVYGQRKHLVEAVNGWIKHVLGFRQFSLRGLNAVQG
+EWDLVCLSLNLRRMSTLMRMV*
+>PROKKA_00226 hypothetical protein
+MRPGEEDKDPLGDFLASLERLSALPENIRVLPSHGLVFEGLHQRLKALQRHHELQIDRLL
+ERCEHPQSARDVLSLMFRRPLDEHAILFAMGESIAHLHHLRLQGKLSQVEQAPFRYIRN*
+>PROKKA_00227 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00228 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00229 ATPase MipZ
+VASLDLDVRQASLTRYLENRAAFAARRGVSLPMPSHRRGNDPTAPDDVAEMIRAQAAGHD
+VLLVDTPGRVDAVSMAAHVVADTIVTPVGESHLDLDLIGNVDRNQGRAIRPGPYAEFVWA
+VRQERARAGRTPTDWVVCHNRRRAPQTRVGREVERTLADLSKRFAFRLVPGFSERTIFQE
+LFPDGLTLLDLRESETGVGLTLSHVAARNEIRHLVDALDFR*
+>PROKKA_00230 Unsaturated glucuronyl hydrolase
+MITIDQTLTPKDLTEDLARFWTLSGQKIRQLASRWNAGDGAPVFTVEGRYTSRGWTEWTE
+GFVYGSALLQFDATGEDWFLDYGRRGTREHMGGHVTHTGVHDHGFNCVSTYGNLRRLMDE
+GKLPENADERAFLDMALASSGAVQAARWTNLGHGKGYIHSFNGAHSLFVDTMRSLRSLAV
+AHMLGRDLKGEHDQSISLIERLAAHARTTAETAVFFGKGRDAYDEWGRTCHEAIFNVKDG
+HFRCPNSQQGYSPFTTWTRGQAWITLGYAEQLEFFRALEAAGRPEADDCSDLMGIMRDGA
+RATADHYIANTPTDGVCYWDTGAPGLAAMPDHKDRPADPFNEHEPVDSSASAIMAQGLLR
+LAAVLAEEGDDSAERYRQAGLTVARALLKAPYLSEADGHEGLLLHTIYHRPNGWDHIPAG
+RKVPCGESCQWGDYHVRELALMIGREAAGQEPYRFFNGLV*
+>PROKKA_00231 Type I secretion system membrane fusion protein PrsE
+MASPDIEYMSELRAAVSRRPTILANIILIAVLVFFILAILWASWAKIDQVSTGEGRVIPS
+GHVQVVQNLEGGILSELYVAEGDHVKQGQVLMQLDDTQFSSDFMENRLKFLGLKAAVTRL
+QAELEGTALKFPAEVEKQLPAVAQAERSLFEARRSEEDASLAKLQAQYQQKLHEVDETKA
+KIEHLRTVIKLAKEEMAILEPLVKKGINAPIELIRLKREESQDAGDLAVARQQLLKLAAA
+IDETKEAITEAKAQFRSRALKELNEAQVNMAALGQVVTSRDDRLRRTVIRAPVTGVVKQI
+FLTTIGGVVRPGMDLMEIVPAEENLLVEAKIRPSDIAFMHPGLEATVRFTAYDYTIYGSL
+KATLDQISADTIFDEAKKERFYMIRLRTKTNSLLDKTGKPLPIIPGMTVSVDVKTGRRTV
+LQYLMKPFHKLSIRAFHER*
+>PROKKA_00232 Toxin RTX-I translocation ATP-binding protein
+MTADNASNIKVVHDPQTDEAPARPLGVDTPAGEAPGNDDRPAGPLEDALPGAEDDDSLLS
+CLLFLVAYHGQPKSPSVLLSALPKPDGPIPVDLFKRAAARAGLSVQVVRRGLGRIHAWTL
+PAVLLLRNRGAVVLTGKSDTGHFLVTAGDAGHGTTELSPEELERAYTGFAILVKPEVDLG
+GERTGADLAKPRSWFWGTLAKNGWTYAQVGMASVVINIFAVANPLFTMNVYDRVLPNNAV
+ESGIALAIGAATALLFDFILRNLRGWFIDFVGRRADVVLACRIFDQVLDLKASHRPQSSG
+AFASMLREFETVRDFFTSATLAAFIDLPFSLFFLAVILMLSPEIGMVLGSAMALVLFWGM
+FVQFPIAKSVKKLMVHGEHKHGVLVESLFGYETIKMVGAEGRMRAKWETVVGQSAAVGQR
+MRLFNNLGVNFVQFVQQGTIIAMVVTGIFLVKDGTVTSGGLVASVILCGRALGPMAQVSQ
+LMMRFHQTWTSLKSLDAVMRGPVERPPEANFLHRPRLRGQIEFQEVTFRYPGTDHDVLRD
+ISFVIEPGERVGIVGRVGSGKSTIAKLLAGLYAPTSGTVLLDDTDLRHIEPSDARANVGF
+VPQDVFLFKGSIKENIAISVPRATDDEITEVSQALGLHDFITQHPLGYDLEVGERGGGLS
+GGQRQAVALARTLLKTPTILVLDEPTNSMDTGTEKKVVDTLARTTGGRTIILVTHRTSVL
+SLVDRLIVMDAGRIVADGPKATILGGLAKGQVKTGK*
+>PROKKA_00233 Outer membrane efflux protein BepC precursor
+VKSFSDAGVAANRRNGHRNATPSGRLGHSLSWGSLLLSGLVVFGGPFMADAQAQQLREAV
+EMAVQSHPMVASTEAEYRAAERSVDQVEAGFYPSLDLTADSGYQHARRVNESSIKENQWR
+NKQRLAMTQMLYDGEGTANRAESAKASAQSAHFDVLSAATKIAQRAIRAYLDVARDRKLV
+QYAVDNIDLHRRILADVEEAARSGGGSETRVTQVKTRLYNAQSQRRRAEGNLRNSISDFQ
+EAIGETPETLEDYPMPTVAIPASVDEARDEALKNNPSFQAAVETERARTLTANAERSGYF
+PQVDVEVAHEQRDGVDGVSGFETDSTALLTLSWNLYGGGADQAKVRRALEQSSAAMYRIH
+EVERKIRRELEVALTDYEVARDQVALLRERAATAKEVTAAYREQFRLGQRTLIELLDSGN
+ELFLARSDLTTAEYRQISAAYDFLAVRGTLLKDMGVKVATGKAPKAP*
+>PROKKA_00234 Bifunctional hemolysin/adenylate cyclase precursor
+VATLELIVERASGDVLKVELKPGTNVPAIHPGDKVQIVTPAGETLNAVVVGQDVQITPVD
+ASGTVGETIVFKNLALYLHDGQSEVAVVNADTGQTTEITDVASLADLGTVPLQMASGEGT
+GPVSPGTSSPFQNSDAIDHGGETAGNAAGTLGDILNRGAAGTDGGRAQLAGTGETGAGTG
+TGSSTTDHVETPISESTEGGGSGTGTGTGTTTSGHAVDGYIVGATVFADANANGVLDSGE
+ASTTTSYNGTFELSGSSGQLVMTGGVDQATGESFKGTLTAPAGSTVVTPLTTLIQSLVEA
+GQSAADAQAAVKSALGLTGNSIDLTTANPVEDVENGVSGADDVLAAAIKIQNTVVQAASV
+LQGAGGSTVAMSTATNAVFAQLATTLQNNPGSNPITDATAVQNLITGAANSSSLGLSSTA
+KTQVGNAASDAASVIDAGNSHINGLSSTGSSLLTDLASAARVAQNGAAEALHDALNAVQG
+TSNSANLSTATSSYTGANLTSEIGNASSGLGTVGTASSVGTSGDDTIQGTSGNDTLNGGA
+GNDTISGGTGNDILIGGAGNDTLKGEAGNDTLDGGAGDDSLYGGAGTDKALFDGNFSGYQ
+IATDSGSSGVITVTGSGTDTIDTTEVLKFKDLTVRMVGDSGGTANGYTSLSSALSAASVG
+ERILILDSATDPSTLTLSKKVSVQKIGEDPLISIASDGALVVDGSQLSAVTTLDLSSLPG
+TTTVRFTSLGSIASISTASTETLNLSASQLDGLTVSGSGKIQTSGIVATSADLSNLSSDL
+SVASGQSLELTAAQASGKTIAGAGNVTVNALGSSAVDLSGITASGTLTANVPSSATLNTN
+TDLGTFGVSVASGQTLTLSATLADGTTIGGDGNVTVTGLAAATDLSSVSASGTVTATVTS
+TVDISSNTHLGSVDAYQVTGALTLTAAQVGDSTISGSGNVTVSGLAATTDLSGIASSLSL
+TASVTSSIDISANTNLTTVDTYQVSSGQTLTLSAAQAAGHAISGGTVTISGNITANTDLT
+DISSTLSFDDGDSGAISVASGTKLTVTPSQAAALQTAGQTITGDGTVLIDGNVTADTNLT
+NISAAVDFNGNSVSVDSGHTLTLTATQASDTTISGAGAVALSGSDTNADLSSITADITVA
+SGQTLSLSTAQLATLDSNAIPIGGDGTVSLTGNATSALNSDLSTYLGSSLNLAVPSGESL
+SLTAIQANGLTMEVAGTANITGPAGTTAADFSNISFTGSGAATFTVGADLVISEANADFG
+SVSINIPAGRTLTIDAADASGVTISGDGTLAVTGTLDSSVNMSNWGTGAIDLTNVSASNF
+SLTQLDLNGSADYHLTYAQVQALSDGIDGNNSDNTLIIDVSTAGGVTYTNNAATIDLDIS
+LLGGADRVKFDFGGTTDSGNTLTIRGPLGFGDGSDTLESRHGTISLTDPGLTLSGGPEAL
+VANSGFSLTATLFDLLYGSSGVTLQGEGTYIVSIDAGFASGASPTLDLTVLDNFVPAGGV
+LPTLQIVATGYSVVGGDDGTGDGIATLSDGTHTITIKLPDDPDNAGTFNPGNTPVIIEID
+NGTSQFFLGGLDDQRAYYESETTVYTGSQFADLATAIATDASSLGINAGDIQTIKLGDSV
+ILDSDSAVDLSAFGGVIDYNGQTIQVTSGDSLTLTAAAADGGTISGAGSVTITDLGTTAV
+DFSGLTAASVTLAISSGTVDLSAISGLDLGNVGITVTTPGAVTLTAAQADGLSISGNGDV
+TLTGLGASEVDLSGLTATNATAEISADLTLSSLTNLGSLDLTLDDGVTLTLSRAQLDGRD
+ISLASGSATLAFGGNASGLDLSQIASGIAFEVVAGRTLTLSTAQINDGHTITGAGSLVVV
+LSGTEVDLASTAIQVTGTRTAVVSTSATLDGNTDLGDFSVSILSGQTLTLSTAQAAEHAI
+SGAGNVTVTGIGSTAVDLSTITVTGTKTVSLSADATLDPDTNLGNFAIDTAGHSLQLTVA
+QANGLSITGSGTAVVTGLGSDTVDLSGITATASTTVSDTVALAAGTNLGSVAVTVDGTGS
+LTLSASQADGHTISGTGAVTVTGLTAGIDLSSLASSLDVTATVPGTVDITGNTAQLATVD
+TYEVAGALTLSASQASGHTIEGSGSIVVSGLDGSAAYDLSGITASASTTVSGTVTLDSGS
+NLGTVAVSVTGSLTLAAAQATGHTLSGDGSVTVTGLAATTNLSGLASTLSLTAAVTGTVD
+ISSNTLLGTVDSYTVSQSTDALSLTAAQASGHAISGSGTVAISGLGAAVVDLSGIAATVD
+ATATLSGTEVILTAGTDLGTVALSVGSGQTLTLGAAQASGHAISGGGDVVVNGLSASTDL
+STVTVTGTVTATVSADLDISASSQLGSVDTFQVVAGKTLTLTATQANGQAVEGGGNVTVT
+GLAAATDLSGITATGTLTATVTADTDITANTHLGAVDSFQVASSTTLTLTADQADGQAVT
+GTGNVTITGLGTTAVDLSAIAATGTLSAAISGDITLAGDTNLGDVTLTVGAGNTLTLTAA
+QADGNTITGTGAVVITGDVAGYDLTHIAGTLDLTLPVTGDVLTLTDGETVHLTVAEANAY
+DSITGDGTIQLSGNATANFDHLTSILGDGVSLAVADGDTLYLTATQASGVTIGGIGTVDA
+SGTVTDGDFSGISADLNLTDATLDGTTTLPTVGAGHTLSMTSDQINAASIALADSTATLH
+VAVSFDALSSSNDALPEIDISEIRVDGSNSPEAVWNSVDVASGSIVDKFKLFWISADKQY
+YDSTPLGQDVDANRAFVELGNLYAAYLAGADGELGTADDGTPILDVVQTKSGGVADYDAR
+QQSLHDNLLGNLSDGAIAGRFGTDDPRSDLAKLFGDRPYLAGSVDGNGLYTNDDSVAAVV
+GWDLYHGLDYTASLSGGYAVLDGDNSVTGTSGSDYIYAGGGDDTVSGGDGADVLYGGSGD
+DTLNGGAGDDTLYGGSGDDTLTGGAGADTLSGGDGTDTASYAASTEGVTVDLETGVGTGG
+DAEGDTLSGIENVTGSAEADALSGDANANVLDGGAGDDTLTGGAGDDTLSGGDGTDTAVY
+TAALTTDNITFDTDHWVVATDGAEGTDQLSGIEVIDHGGSGNILLVGGDGFASIQDAIDV
+ASDGDTIMVAPGTYAESLTIDKSLTLIGDPATGDAGAGTSAPQILGSTDWTLATVSIEAE
+NVTFSGFDVTNDTGPYGIHIKAGDADVSDNYVHDINGALSGDGIRAIFINPVDNVTVSNN
+IVEDFGNADNPSAASYTKTAAGIYYWARGGTLPGGTADIAELHNVTIENNVIHNDGLPTF
+TGTSVLGIWVGSSQGGSVLDTVSIAGNQISDLHTDNADRLTGGILVNHGSNPDGVDPLAS
+LDTPGVTTGLEISGNTIDDVSGASVFAVGLRGQTPDASVIDNVISNLALASGSSDGLLAS
+ISFQYNTTTHSVSLSGNDLGGYDLLQVGHDTSDDTLTPATADDTLTAIDGYDNILVGQSG
+DDTLTGGDGNDTLLGGNGTDTLTGGGGTDTLDGGDGTDTAIFTGTRADYTIAVDTDGHLT
+VTDTGGTDGTDSVSNVETLEFTDTSVSVLTVTETGANGTYSSIQAAIDAAADGDIIYVAD
+GTYTQTGTLNVDKAVTLIGQSEAGVVIDASAVHGYGILLTADGATLSDFTLNGPQGGDET
+VWSSYRVDYGIKVSPNGTASSLSDITLQNLTVSGSHNTEIDFNGIHDSTLSNITVDGGTG
+VAGNGISLTDSSNITVNDVTAANNPWGGVAIYTDGTHYAGGSDGVTFTGDYTYDAGSTGA
+SPIYIQATGNTYPVTNLTLPDGYDFAVTNSEYRADGNEFTFFFTSESDATAFGNSLGAGS
+FVSTPDADTLTGTANADYLYGGGGDDHLSGAAGDDRLVGGSGNDTLDGGDGMDTAAVEGN
+RADFTFTDDGSGHLVMSDTQGTNGTDTVSGVETLSFTDGNVLVVGAGSEYATIQSAIDAA
+ASGDTIVIAGGTYAESLSLDKALTLQAVSGADVVIDPASGNGLTVSGDLAGGDVTVSGLT
+FTDGTMGIQVAANADVGTLTLDGVTVEDNLQYGLRTDSGSMAAVIVTDSTFGDNGTQNVN
+GSAQMKLYNFDGDATFTRVDLVGAPAGTDQNSRPDYGIELTGLSNTGLAEGGTSPDLGTV
+VFTDVTVSGEFHKIGVAVYNYGQIDGLDIQSLDLSGTETNWGPVFNIDGVEDSTVDARNY
+NITYPAGDAIVAELQGEVPDQTATDTTIYGTDANERLMGKAGDNVLHGGGGNDELYGADK
+PGNPAEDDSGNDKLYGEAGDDLLAGGAGADILDGGDGIDTASYARAGATEGVAVDLANGT
+ASGGDAQGDVLSNIENLVGSSYDDTLTGDGNDNVLTGGAGADALDGGDGSDTVSYAGSSA
+AVNVDLATNTVSGGDAEGDILSNFENVTGSSHDDTLSGTSGDNVLVGGEGNDTVVYTTTV
+AASDVSFDTDHWVVTTASAGTDQLSGIETIEHGGGSNILLVGGGGYATIQAAIEAAGAGD
+TILVAPGTYAPFATSFGGPANITVQAMGDPGDVIIDATGGAPSNGRILDLRADGMTLDGF
+TIEGPGHAGVGISINGQGITVENNVISNVLTGIQTGTQYDTGNVTITGNTVDADYGISLQ
+NTANTVTDNTVHATTEGLGVLDVAATLSGNSFTVDAGGEGLALYGGATSSTFTTSGNTVT
+VGEGANLQHATDLAGTDGTLNIGAGTYEQVISIAKDGLTVNGSDATLVVDGSSSDVNGIA
+RVDAVTIYGDNVTLQGLTIVDSLVDQSYVTYGWPETTRGIVVKNGAENFTLTGNTIESTR
+NGILINGIDNTGSVTDNVIDNTKSGISVQYTDASGIIIAGNQEGTYGNEWGLNLHLNGYW
+DGTTYTSNNADNYPILGTAPTADWQASLLGLSTGNDGWAVMDQAYALYNRTLVTVDPDGS
+PSSFSNQGSQRSPISTIQNGVDLVVAGGTVHAHAGDYSGESVTVHVDNLILDGDAGATGI
+TVQLADGLSNLTLAGEADYTATGNAADNTLIGGAGDDVLTGGGGADTLTGGDGSDTASYA
+ASAAAVDVDLGSGTASGGDAAGDTLTSIENVIGSAYDDMLTGDAGDNVLQGGAGADSLIG
+GAGSDTASYADSSAAVDIDLAAGTIAGGDAVGDTYSGIENLTGSAYADSLTGDSGDNVLT
+GGAGNDTLTGGAGNDTIDGGAGTDTAVLSGNRATYTLGVNADGNITLSGEGTDVVKNVET
+LQFADDSASILVVDPGTSGAYATIQAAVTAASAGDIILITGGTYTENVTLDKQVTLLGAQ
+AGVDADGRTGVTESVIEGNITVSGAADNATIDGLTIHNGASVGGDLAGVYLASGATGTEI
+TNTIFTRDGTVDGDSSRGILTTYNGGNTDVTIAHNSFSGWATGTYVNPGSQDIQITDNQF
+DGNYVGLSVDGPNGAVVTGNSFTGNQFEGLGIGPGTGISGITLSNNSFADNASQVGVYTD
+AIDVNALSGNTFDGAVVISGSDTVYASIQDAVDASSDGDTILVYPGEYSELANYNPTTGE
+NSGTGNPLGLLINKSVTIQGVTADGTYITDAGDVAATVTSGAQSNWGTNFFVTADDVSIN
+GLDLVATGSTGQPYVNKSIEVVGDGFTLNHSVLGAADGLPMYTAVYVNDWSVDSGFTASA
+IASYAVLNSQLYGDMVVTNGPGTGYTADQLDMRIVGNSFLTIDGGIPNDGILVTGNDDNI
+AWRNASAALPTEISGNDFGDASGVLWVRGDGTQDFPTTAEVNGILADNSVPAYAYAVDGN
+GDLAAGTYGSSSIPSLAIRATAADFAPSELSGAGAESLMVQQAGETTPHSYSLIVGADGV
+ADSLTGTSGDEALIGGSGDDSLSGGGGNDILVGGDGNDTLTVGDGSAVVYGGDGTDTTAY
+STTVSADDISFDTDHWVVNTSSGTDQLTGVEAIDTGGSNKILLVGGDSGYATIMEAVDAA
+SAGDTILVAPGTYEPFSMGYWSPSDLTIQGMPGAVIDATSISTPARIVDLTAEGTTFSGF
+TIVGPGDVDDAGISVGISISAQGVTVSDNTISDITTGIQNHTPADQTGASSILDNTISGA
+NVGISLQNVNNTVSGNTVTTVEAHTLGVGEVALGVLGGDNTITHNTFTVSNSGKAIGLPD
+LPAVANLTTSENVVTVGEGADLQNAADLAGTNGTLHVGAGTYAQELTITTDGLTVTGDDG
+ATIQVADPGVYSPSSDAFAARTIAFTIAATGVSVSGFEINGPLSAYTYTTTDFATLGYTY
+GFFINDGVQNTTLHDITIQDIRTGMSFEGDNTATVYDNVIDNTRGAFLVRSDGVDLHDNS
+FGSTGNEWDLTMLAGTPSDYFGDPLTDPGTYGDNMMALSAANNDMTIADRMYGEGGVLAR
+AASDPDLADQYAAVANRSHVEVLAGADNDTSAGLGETRGNGFGTERLPVGTLQDGVNAVV
+QGGSVHVQGGDYSGESVTVHSDNITINGEASAIGIDVHLGIGLSAITLEGSADFTATGND
+LDNTITAGAGDDILSGGDGADILFGGDGNNTLTGGDGADKFMISAHTDGSKDTITDFGQG
+DSLDFHDVLSDPTDVVFTDDGSGNTQITTNAAPTIVLAVVEHVEPASLTVDDHGNVTLAQ
+TS*
+>PROKKA_00235 putative succinyl-diaminopimelate desuccinylase
+MPAKIPDPVELTRRLVAFETINPPGQEQACAAFLADLLAGAGFDCVLHPLGDDRASLVAR
+RGRPTEQRLPLAFTGHIDTVPLGAVPWKHDPFAGEIVDGRLYGRGSSDMKSGVAAFVVAA
+IAEAERIGDGAGVELVITAGEETGCDGARALADGGHLGRAGALVVAEPTANRICVGHKGA
+LWLKAITHGVTAHGSMPEHGDNAVYKAARAIGRLADFDFNVARHPVLGRPTLNVGTVSGG
+LNVNSVPDRATVGIDIRTIPGMDHAPLRDGLGGVIGEGADLETLCDLPGIWTEPELPWVQ
+RAAAAVAAVTEQPFAPESVAYFTDASVITPAYGDIQTLVLGPGEPSMAHQTDEYCEVERI
+VEATDIYRRLIADWMKPES*
+>PROKKA_00236 High-affinity branched-chain amino acid transport ATP-binding protein LivF
+MTAVSSAVSDSAAVPQTADVAVEIEGLFTGYDKADVLLDVSLTVPKGQITCLLGSNGAGK
+TTLIRSILGLTPPRQGTIRLFGEDTTGLPTHKVVARGVACIPEGRRMFSKLTVEENLRLG
+AYQEPSEAKIRTSLEDVYQTFPRLAERRNQLSGTLSGGEQAMVSIGRGLMGAPRLLMIDE
+PSLGLSPLYVQENFRIIENIRTRGITVFLVEQNVHQTLAISDYGYVVSGGRLVAQGAAAS
+LQNDPEVHAAYFG*
+>PROKKA_00237 Lipopolysaccharide export system ATP-binding protein LptB
+MIGNYGGLEHGLLFNLFRRRAFRRQYEEALEEARGLVATFSRNLADRLFDPVGALPMIER
+RRIEICRALIAHPKLLLLDEPSAGMTHDETHQLMDDILSVRDRLDGLAIIIIEHEMGVIE
+RVSDHCVVLNYGRKIAEGSYQDVASDRLVQEAYLGSA*
+>PROKKA_00238 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00239 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00240 Glutamate synthase [NADPH] small chain
+MGDPKGFMTVPRKEASYRPRNERIYDFGEVEQTLNEEDRKLQTSRCMDCGVPFCHWGCPV
+GSKIPEWQDAYYRGNEEVAYEILHSTNSFPEITGRICPAPCEKSCVLSINEEPVTIRENE
+AANVENAFTQGWIKANPPSIRVV*
+>PROKKA_00241 Ferredoxin-dependent glutamate synthase 1
+MEKKRKEMAFRFPKPDGLYNPANEHDNCGIGFVAHIKGEASHDIVERGLEVLRNLDHRGA
+KGSDNASGDGAGVMVQIPHEFIKKVLKIDVPAKGSYGTGLIFLPQLEAEANACVDILSNI
+IQEEGLQLIGYRDVPTDSSIPGEIARTTEPRIKQVFIKANLEEDILEQKLYIVRKRAEKA
+VQASDLSQKEVYYHSSLSAKTMIYKGMLTPDQMKDYFTDLQHPLFKSALILIHSRFSTNT
+FPTWDLAQPFRLVAHNGEINTIKGNRLWTQAREGLLKSEVFGDDLPKILPVLEEGKSDSA
+SFDNVLEFLHRTGRSLHHSLCMMIPESFNEKNPIPESLKAFYEYHSTIMEPWDGPASIVF
+SDGRYIGGTLDRNGLRPSRYVITKNDLIVMASETGVQDFAAEEILEKGRLRPGKILLVDT
+RLGIIIPDEEVKEQLSRRNPYGMWLKENRLLMEDIKVRQRVPSTMDDFLTYAKVFSYSKE
+DMEFLIQSMSNTAVEPINSMGNDTPAAIFSRQPQRLFNYFKQTFAQVTNPPIDAIREGLV
+MSLTNYIGSLNSNILKESPDHCKLIKFPDPIVTNTDLGKIKDLKDEMFSHEIISIVFPVD
+QGFEGFKKAFDEMLERAEKAVDDKKNFIILSDRAIDSKHAPFPSLLAVSAVHHHLIQKKK
+RMQVGIAVETGEAREVNHYALLLGYGASVINPYLAFAAVDHLVKEGKLDMEYKDARRNYI
+KSIKKGLLKIFSKMGISTVRSYHGAQIFGAFGLSKELVDKYFKGTSSPISGIGLEEIYEE
+YSQFHKDAFREEATQEKFRFETTGVYAWRKNREDHAWNPDSIGLLQWATRTNSYEKFKEY
+SRTVDEYNRKPSFIRGCFQVKRNSISIEEVEPVEEIMKRFVTGAMSYGSISKEAHESLAV
+AMNTVGGRSNTGEGGEDHNRFGTEKQSAIKQIASGRFGVTSNYLTNAREIQIKIAQGAKP
+GEGGQLPGYKVNEVIAKLRNSTPGITLISPPPHHDIYSIEDLAELIYDLKATNPKAKISV
+KLVSQDGVGTVAAGVAKAFADLIIISGGEGGTGASPISSIKHAGLPVEIGIAEAQQTLVK
+NNLRGRVKIQVDGQLKNGHDIVTMACLGAEEFGFATSALITLGCVMMRKCHLNTCPTGIA
+TQDETLRERFTGNPQLVINFFRFLAGEVRELLAEMGFKKFDDIIGRADLLEENKEVFGWK
+MKNVDFSAVLNRPAEADKFDIRYVPGSASLNLDGHLDHTLIEESGKAIKGKEKVWLHHPF
+ANTDRAIGAMLSGVISQKYGEFGLPEDTIHATFDGSAGQSFGAFLAKGVTFRLEGDSNDY
+IGKGLSGGKIIVVPPTGSTFTPEENIIIGNSTFYGATGGEAYIQGVAGERFCVRNSGMEA
+VIEGAGDHCCEYMTGGRVVVLGKTGRNFAAGMSGGIAYVLDEDGDFDFYCNKGLVELLEV
+EDKKDIKELQGLISKHLTYTQSPKAAKILTQWEEYLPKFVKVIPYEYRKVLRERELRELE
+QKMKMTEDANVMQE*
+>PROKKA_00242 Phosphoserine phosphatase
+MLEQKELILLNISGEDKPGLTASLTEILSQHNVNILDIGQSVIHKDLGLGILFEVPKKYR
+SASILKDLLFKAYELKSHIKFTPIPIEEYEKWVAEQGKERFIITLLAHKLTALHLSKVSS
+LIASQKLNIDTISRLSGRKSLNGNNKVTNSVVEFSVRGTPLDINAMKQSLMNIASETGID
+IAFQEDNIYRRSRRLVCFDMDSTLIQTEVIDELAQKAGVGDEVKKITESAMRGEIDFKES
+FKKRVSLLKGLDESVMKGIAENLPITNGAERLLSTLKQYGYRTAILSGGFTYFGNYLKTK
+LGFDYVFANELEIKNGKLTGKHLHEIVDGKRKAELLELLAFKEDIHLEQVIAVGDGANDL
+PMLEKAGLGIAFHAKPKVKASAQHAISATGLDTILYLLGFRDREINAS*
+>PROKKA_00243 N5-carboxyaminoimidazole ribonucleotide synthase
+MLIQEASKWDIITYVLDNDETCPANSLATHFVKGSNLDFDSVYRFGKMVDLLTYEMENIN
+IEALKKLKSEGHQIIPDPDILELIQDKGKQKEFYQDNNVPTAPFKIYSSRQDIVQAIKNG
+EIKFPFVQKLRTGGYDGRGVAVISDENDLDKLLDGASIIEDKVNIAKEIAVIAARNKQGE
+IKCFPVVEMVFDPEANLVDKLICPSKITAEQSEKAIEIAGKIIGLLGMQGLLAVEFFVDE
+NGEVIVNESAPRPHNSGHHTIESIITSQFEQHLRAIFNLPLGSTRPKLPAVMVNILGGEG
+YEGPVRYEGLTEIMAIEGVKIHLYGKKITRPFRKMGHITVLSDSLETALEKAEKVKQLIK
+VKSWDKN*
+>PROKKA_00244 N5-carboxyaminoimidazole ribonucleotide mutase
+VGQKLVSIVMGSDSDLPVMKPAAEMLEQLGVEYEIDIVSAHRTPEKLFDFASNAHKRGIQ
+VIIAGAGGAAHLPGMVASMSPLPVIGVPVKSSNSIDGWDSVLSILQMPGGVPVATVALNG
+AKNAGILAAQIISVSDSQVREKIIEYKAGLKEAVMKKAKNLKG*
+>PROKKA_00245 Cyclopropane-fatty-acyl-phospholipid synthase
+MDPKTVIRELLTGTGVHLNGPHPYDVQVHDERAYERWLSEAELGLGESYMDGWWDCLALD
+EFIERILRAGLEEKVKRNFSTAFYVLSKRLFNQQTRVKSKRVGREHYDLGNELFSKMLDR
+RMVYSCGYWQRAKNIDQAQEAKLDLICKKLNLKPGMKVLDIGCGWGSFAKYAAEKYGVEV
+LGVSISKRQIELGNELCKGLPVTLLYKDYRDVEGKFDAVVSVGFFEHVGYKNYDTYMKIV
+DRCLTDNGISLLHTIGNNTTTHYVNRWTNKYIFPNGMLPSIAQVAKAAEPYFVIEDFHNF
+GPDYDKTLMAWYDRFNKAWKELKNQYDERFYRMWRYYLLSSAGGFRSRATQLWQFVMTRT
+GRQQPDCRFA*
+>PROKKA_00246 hypothetical protein
+VAHAATTGNNETLLCRFPTLHNNTIVFEAGGNLWRVDRTGGVATRLTTDPGYDMMPRFSP
+DGKTIAFTGQYSGNVDVYTIPADGGAVTRLTYHSDVVRKAPTRWGPDNMVMTWTPNGKDI
+VFLSRRDTWNSWFGQPFEVSKMGGLPTHLPLPKGGVMSYSPDGSKIAYNRIFRNFRTWKR
+YKGGLAQDIWIYDFKTKKIQRVTKWKGTDTYPMWYKNTIYFASDRGANHRLNIWAYSLDT
+KTFRQITHFKNYDVDWPSLGNNGIVFQDGGSLYVLDLPSEQLHKINVKVPTDGTQTLPRW
+INASKMIRSLDISPNGKRVLFGARGDIFTVPAKHGATRDITQTSDAQEQYPAWSPNGKWI
+AYLTDASGVNELAIRPSDGSGHQTYITNAKTGYYYNPTWSPNSQMLAYSDNNHVLWYISL
+KDKKPVRIAQDKYNAMRDYHWSPDNNWISYSKTNASGLSQIYIYSLADHKSYKVSDGIYS
+DNDPVFGPNGKYLFFVSARHENPLFSESESNVATEKMDGIYMVTLQKNEKSPFAPVSDEG
+MPEAKKASSSASKKTESAKDVKIDFNGLMNRVIMLPIKSGDYGNIQVTGNKVFYQTRPLI
+TIEGFLHGTGQSSIMVYDLKSKKGHTVVANGARTYGLSADGKTLVYMRRGKFFLMPSASV
+NAKGSEPVNTSHMKMKIYPHQEWSEMFHQAWRLFNNFFYNTKMNGVNWNEVGANYGKLVP
+LLGCREDVNYLVGEMIGELDNSHCYVWGGDDNYLGKTNPTGVLGVDFGLNKSSGRYYFKK
+IYAGDNSRPGYGSPLDRPGVNVKTGDYLLAVNGHQLKAPMNPYSLFVNTVGQQTTLTLAD
+KPDGKGEHTVTVKPINNSLNLRLLNWIRTKRAYVNKKSDGKIGYIYMSDMESLGMTQFIH
+QFYPQLSKQGLIMDDRFNGGGFIDQIVLERLRRVLIGMSTNRAHAAMRYPEQVLHGYKAC
+LLNHYSASDGDMFPFYFRKYGLGPLIGERTWGGVRGYNRVWTLLDGGNLVVSQNSIYGLD
+SKWAIENHGVTPDIKVDNLPGQVMEGKDPQLDTAINYIMKKLKEHPMPIPQPPAEIPAYP
+SGNDAGGTN*
+>PROKKA_00247 Histidinol-phosphatase
+MIRYNLHQHSIFSDGAAEPEAYVQSALNLGFEAMGFSEHSPLPFPTKFSLKAERVEDYIR
+ETERLKEKYNDRIDLYRALEMDFIPGYSENFTEWRKKAQLDYAIGSVHMVQPEDDGELWF
+IDGPDRSIYDDGLQNFFGGDIKKAVKTYFHQVNRMVETQDFEVVGHVDKIKMHNQNRYFT
+EEEKWYRDLVEETLHLIKEKDFIVEVNTRGLYKKRSNRLFPDDYALQRISELGIPVLISS
+DAHKPEELNLLFETAEKRLLDMGLGAVVRFDHGKWKDFPLS*
+>PROKKA_00248 Ribose-phosphate pyrophosphokinase
+MMIDAAKRASARKIVAVIPYFGYARQDRKDKPRVSIGAKMIANLLTTTGIDRLITMDLHA
+DQIQGFMDFPVDNLYASVIFYPYLKKLNLPNLMMASPDTGGTRRAANYAKALDTGFVICY
+KQRTRPNVVEQIQLIGDVAGKDVVLVDDIIDTAGTITKAARVILDKGANSVRAMVTHPIL
+SGDAFKIIADSPFTEVVVTDTIPVKDDLGGKIKVLSTAQLFSEVIKRVENYKSISSLFNL
+GNQSNK*
+>PROKKA_00249 50S ribosomal protein L25
+MNTVSLSGSLRENVGKKDAKKQRRLGKVPCVIYGGSEQKHFTLDQLEFKPLVFTPEASVV
+NLTLGEKTYECILQDVQYHPVTDEILHADFLEIHSEKPVNIALPVELTGTAPGVVKGGKL
+RLKMRKLRVNGIIKLMPEHIVLDISKLDIGRSIKVRDINQANLTFLDPGNQVVVAVVAAR
+GLSAEEEAEEAEEGEEGEAAEGGEEGGEKSAE*
+>PROKKA_00250 Peptidyl-tRNA hydrolase
+MKYLIAGLGNIGVEYANTRHNIGFIVADALVNELKGKFETERLASVASVKHKGRTLVVIK
+PTTYMNLSGKAIKYWIDKEKIPIERVLIVVDDIALPLGTLRMRKKGGAAGHNGLSDIIMK
+LGTEKFPRLRVGIGDDFAKGYQVDFVLGQWTDKEVNVMIPRVQKAVEIVQSFVSAGIDNT
+MNLYNNK*
+>PROKKA_00251 hypothetical protein
+VFQGKHQLNVFINILTQIKTMLRIRNFNNFVSNFLKIFAKFYNQAKIISYRLIILLQASV
+TGQPNHSIEMEKQRQQSGLLFKIK*
+>PROKKA_00252 3-oxoacyl-[acyl-carrier-protein] synthase 3
+MAVEAVRGLLEKTGTKPEEVDLVICATVTPDMQFPATANLVSYKLGINNAFSFDMNAACS
+TFIYALITGSKYVESGEYKKVIVIGADKMSSIVDYTDRATCVIFGDGAGAVMLEPTASDE
+PGIMDHRFYTDGAGWIHLHQKAGGSLKPASHATVDAKEHFIYQEGQPVFKFAVTRMADVA
+AEIMERNQLKSEDIAWLVPHQANLRIIDATARRMGVSKDQVMINIQRFGNTTNGTIPLCL
+YEWEPQLKKGDNIVLAAFGGGFTWGSVYLKWAYDGKK*
+>PROKKA_00253 Catabolite control protein A
+MHYNPNAFALSLRNSYSKIIGLIIPEITLYAFPSMIRGVSEFCYNAGYNVLILSSNESYK
+REVQNTELMLSSQVDGLLVAITKETRNHKHFDQLEKEGIPVVFFDRVFNNYGTSKVIIDD
+RRAAYEATEHLIKTGRKNIAYFGGNAALYITQQRLMGFRKALSDYNLEEHDLVFADDSHM
+ARNKALQIFKRKNYPDGIMSISDEVLTGIIPALQELNIKIPNEVGVISFSDGPISQMYKP
+AISIVHHSLARVGQVAVDLLIQRIEHPEDMHQQIHIIDTELIARGSTAIGK*
+>PROKKA_00254 Vitamin B12 transporter BtuB precursor
+MKKVVQAFMVLLALTITTGLMAQGTIKGTLKTTKGKTVPGVNILLKGTTTGTTSSLNGSF
+VLKVPAGKHVLLVSFTGFKPINYSFTIKDGETLTKNFVLHEDLLALDQVVVTGVQNKQTK
+LQSSVAITTLSPQKISQIAPRSAADLLKAIPGFYVESSGGKGNANVFARGLPSSGGLRYV
+QFQEDGMPVFEYGDLMFGNTDIMVRIDQTMSRMEAVRGGSASVLTSDAPGGIINIISKTG
+GPTTKGVFMQTIGLTYMHARTDFDIGGPVSKHLRYNIGGFYRADNGIRSPGFLANNGGQI
+KANFTYTFNKGYVRFRTKILNDKTIAYLPFPMMGNPAKSIPGFNANYGTMKSLDLLHLHA
+TTPTGNSVNESLADGMHPKIFAFGGEAFFDLGNKWSLKDNFEKTFTHIQFNSIFGVNAPE
+SASAYATAQGLTNYHYAFADGYNAGKPITNMSSLNGNGLVATYGWWSVGLNLQEFGNDFK
+LTKQSTNNTFTAGWYFSTNQVGGNWWWHNMLVDISGHNTRKLNLINDNTGESLTTNGYSQ
+YGTLYADYNALTVINAPYVYDEIDLGRLTINAGLRWDMGTITGRVENTGSYSYDVNGDGI
+ISPAEKNIQYGNGTYTPFHYDYSVLSYSLGLNYEFNKSTAIFARASQGHRSPADRAYVFG
+ATTSTPNGFPSSAKDESIEQYELGLKYNSSKVALFATGFYSFFNHIDFTDFVNVGGNLTA
+IQQYYNTSAMGLELEAAAQLGKLNLSLTGTAQSAKYHNWVYHDQSGNLHDFNNHFIQRLP
+KLYFTFRPSYNFGKLNVSAAWEYFGKRYTNPENKQVLPQFSQINAYIDYTVSPHITISAA
+GNNLFNVIGLTEGNPRSGLVSTGGSQYFYARSILGRSAILSFKYSF*
+>PROKKA_00255 Sodium/glucose cotransporter
+VKHIDISPIDIAIIVIYIVGIAVWGLMYSKKKSKGKGHEGYFLAGRNMTWPIVGITLYAA
+NMGSPALVGLAGDAYSTGISVFNYEWMALVVLVFFAIFFLPFYLRSRVYTMPEFLQRRFD
+IRSRYYFSFITLVGNIIIDTAGVLFSGALIVKMIFPAMALWHIIAVLAIITAAYTITGGL
+SAVMYTEAVQGVLLMLGAVLLTFFALKRIDFNVARIFTETPHHMMSLIRPNSDKAMPWLG
+LVLGVPLLGFYFWGTNQFMVQRVLSAKNTNHGRWGALFAGILKLPGLFIVVLPGIIGRLI
+FPHLSDPDLIYPMMLFHLLPVGILGIVLAGLIAAISSSISATLNSASTLMTMDFVNNLKP
+GLTPKQLVRIGQIFTGVFVVISAAWAPMIAGFPSLFKYLQQVLALISPPVVAVFLLGLFW
+KRANAQGAFYGLMGGLLMTIFAVIVRYVNPDIFPWLGHIQFLLVAPVLLVGTMAIIVPVS
+LMTPPPPEEAVAQFTWSFKFFNAESMELAGTPWYKNYRYQAIGALLATAILVYIFR*
+>PROKKA_00256 Plant neutral invertase
+MEEAKNTYSKALDLLKNGLLKEGFVAALDQQANYRRVWARDSIITGLSALLADDTTLIEG
+MKKTLISLKQHQHANGMIPSNVSFDADGNVTMVSYGTLTGKVDTNLWFIIGVMVYVRKTS
+DTDLLKEMLPAIEKVFELLLSWEFNGRGLLYVPQGGNWADEFILEGYNLSEQLLYYWALS
+EASAMDEKFSTKAKKLKDLIEINYWPTESNRSKVYHKTAFERQLEKGQTSHWLPGFKPAG
+YHTFFDCFAHGLSFVLQFNSPEQEGEIIETLVRTTSETSGSLLPSFWPPVRETDAQWETL
+QTNWIYKFRNQPGAYQNGGIWPISNGLLIAGLYRSGHKGMADKMKEALFLATALPENQFG
+FYEYIDAFSWEPGGAKHQLWSAAGVIFAEKAAQNVFIV*
+>PROKKA_00257 Uridine kinase
+MEGDIINLNDEHRSTARKIVAPLIEEIKNCQTIYTFSVAGESGAGKSITAAAIAEQLELA
+GFSVKVFQQDDYFFLPPFTNDQKRRKDLEWVGIKEVDLALIDEHLKAAKDGVKTIKKPLV
+IYGKNKITSEVFDMKGVNVCIAEGTYTSLLKNVDKRIFIDRDFFDTHNDRKKRGRDLIDP
+FTEKVLEIEQCS*
+>PROKKA_00258 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00259 hypothetical protein
+MAKGGLGVVVRGIPGYRARIRPIVSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAG
+VIAKRPAPIALPNSCAAEWRMAPDAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00260 putative GTP-binding protein EngB
+MQVYPKFLLSATAPAHFPPPSAPEFAFLGRSNVGKSSLINALLGSRQAKVSSTPGRTRAI
+NFFSLTTSPNRQQPNFLFADLPGYGYAKISKSISAEWPKVV*
+>PROKKA_00261 ATP-binding region
+VKKVWLSWSSGKDSAWALHILRQQKDVEVVALLTTLNEHFDRVAMHSTRRDLVEAQARAA
+GLPLVRVPLPWPCSNEQYEAAMGKACAKAVAEGVEAVAFGDLFLEDVRQYRVEKLAGTGL
+EPLFPLWGLDTRALAREMIAAGVKTRLVCVDPRKMPREFAGRDLDEAMLRELPEGVDPCG
+ENGEFHSFVYGGPMLGEEIPVESGEVVERDGFVFADVKLKH*
+>PROKKA_00262 putative 3-hydroxybutyryl-CoA dehydrogenase
+VSEIQIVGVVGAGTMGNGIAHVFAKSGFQVRLCDVEQRFLDRGMDTIRKNLGREVTKGKL
+MQEEADAAVKRIEGTLARAALADCDLIVEAATEQLEVKRQIFEDLDRVAKPEVILASNTS
+SISITKLAAFTERPERVIGMHFFNPVPVMKLVEVIRGLATTQETFEMVKALAERLGKTAV
+EVNDAPGFVSNRVLMPLLNEAMYAVMEGVATPEAVDQVFQLGMAHPMGPLTLADFIGLDV
+CLDIMRVLQEGLGDPKYRPCPLLIRMVDAGWLGRKSGRGFFEYGNA*
+>PROKKA_00263 Putative metallo-hydrolase YycJ
+MVRMTVLASGSKGNSTVVSSSRTRLLVDAGLSCREIFRRMQAAGEDVESLDAILVTHEHQ
+DHVQGLAVTARKLGIPVYFTEATHRAWMRWMTPRKRLTYAQWLEQQKAIVAAGKEPAAAG
+AEAQDAAEEDISGAKPKKDPCALPAVEYFSSGTDFQVGDIAITPYTVPHDAADPVGFVFE
+AEGVRLGIATDLGYVTPNVHLHLKKCDVLMLESNHDVDMLRDGPYPWSVKQRVMSRVGHL
+SNDAAADFLENSYDGRAAFVVLAHLSESNNLPELARVSAERALRDRMNLLGNKLMLASQQ
+TPLEPIVL*
+>PROKKA_00264 hypothetical protein
+MKTCIDPVVGDILSSWRYDISGITPEMRIDYEEHLASCSVCRSRQRLHRAIDVVLIGLTT
+LSTIVFVLALAVIHHVEPLRTFALFIFHIRDFSVVLTLQAVAFAGLVVSMFAWLLVAVAT
+PVPTFLSGVAREQARELQSRIPEEWRNRFQRGAL*
+>PROKKA_00265 Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
+MSATRGIQHGVDMRVEVADIQLPNPVLAASGTFAYGIEFEDVVNLDHIGGFVTKGISREP
+LSGNPAPRLIETAAGMINAIGLQNIGADAFVQQKLPALARYQCPVIVNIFGYQMQDYIAV
+IRRLNEAEGIAAYELNVSCPNTHAGGIAFGIDRAALSDLVAHARHYSRRPLIVKLSPNVT
+SIATMARSAESSGADAISLVNTFVSLAIDVETRRPRLSNITGGLSGPAIKPIALRMVWEA
+AQAVKIPVIGMGGITTPEDAVEFLLAGASAVQIGTASYADPRAVEHIGQGLAHWCSRHHI
+AKVSELIGGMQTGQ*
+>PROKKA_00266 Trehalose-6-phosphate phosphatase
+MTKNQDCMTLPVRWEQAPAREDFWQELRTASRWLLLLDYDGTLAPFHQDRMKATPYAGVK
+ERLEQLLKIEKGRIVVISGRQIEDLKQLLQLSQPVEIWGSHGREHLLHDGSYRLVDLTED
+ERRVVEAVTARMSERGWAGQLERKPTAIAVHWRGLPVSEQKELREAAEQYFAEANPPDTL
+EMMPFESGVELRSRSRTKGQVVAEVLAEEPADIPTAFLGDDWTDEDGFAELRGRGVGILV
+RPEARESCADYHLTPPEELLEFLDRWLENAKESIR*
+>PROKKA_00267 Trehalose-phosphate synthase
+MSENQVIIVSNRLPLSMTVKFGSLKVGRSSGGLVTALQPILKSRGGTWIGNGGTREDKRM
+ARALEEEARRSGFDCVPVFVTEQEDRNFYEGFSNQVLWPLFHDFIGECRFEPEYWDFYRK
+VNGKFADAVMRVYNGKQILWVHDYQLMHVAASLRERGCKGRVAFFLHTPFPSYDVFAKLP
+WRRHLLLAMLEYDLIGLQTERDVRNLVSCLRRLVPEASMSTDHGVHRVSWHGRTVVIQDF
+PISIDFDEFARAANQPAVEERMRTILARMGMGQVIFGVDRQDYTKGIPHRLRAYGELLRR
+RPEMVGKVKLVQIVVPSRQNIPGYEALKSRIEHLVASINGEYTQPGWVPIHYIHRAIPRE
+ELLALYRAAHVGLVTPLKDGMNLVAKEFCASRIDDRGVLVLSEFAGAAAEMYRGALLVNP
+FDLEGVADALEQALQMPGAQQQERMRKLRRFLKHANVHRWVEDFMEEIESVKAPRSRRG*
+>PROKKA_00268 Anti-sigma-B factor antagonist
+MSMKVTTRQVDGVTILDLSGRILLGEGSVQLRDAVRDLLAKGQKKILLNLGDVTYIDSSG
+IGEMASALTAVRNQGGDLKLLNLTKRVHDVLQITKLYTVFDIKDDEASAIASYN*
+>PROKKA_00269 Serine-protein kinase RsbW
+LRGQQETRVTYTLASSLDSVDKVEQTAEQMARNAGIDEDEAFRVSMAVREAAVNAVLHGN
+AYAPDKRITVTFENNGSDLIIHIMDQGEGLDPAALPDPLKPENLLSGSGRGIFLIRSFMD
+EVHFKQLHPGTELTLVKHLGTAKQSLQGGNSL*
+>PROKKA_00270 Magnesium transporter MgtE
+MPVRLMPMPEVDAKVTLTMLLGTPVTDATGKLRGKVRDVAVATGAEAGRVAGLVVKNRDG
+LQVVTSVDLRRTPSGTLELRADAQMRPLTGEESFLLLRQDLLDRQIIDVHGRKVVRVNDV
+ELDWWNQERGAAGQQESLRVTGVAVGLRGALRRLLLGLMPQATLDRLARKVPQRSIPWEF
+VDIVEVDPARRVKLKIEHERLARLHPSDIADILEDLAPAEREALLRSLSEELAADALEEL
+DPKLWRSLLQSMDSETAAGIVEEMDPSAAADLLADLSKADSEAILGEMDPEERQEVKELL
+EFREDSAAGRMTTEYVAVPEDATVADCVAALREFEGDPETITEIYLLGEDDLLVGVVPLA
+RLVLAREETRAQVLSEPETITCELEAHQNEVAELFDKYNLRALPVVDEQRRLAGVVEADH
+VIAFLRERR*
+>PROKKA_00271 hypothetical protein
+MHPQRSRAGHNNEPRHHVGKERAHHHVGPRSRVVLHSNALLHHRRLQIELHPRRNRRADD
+ADHHEQVAVLPPHRAVRQRHRLQYGQVPVGRGQHARRHISNVENRSHQKDLFHPLVIALD
+RQQPHQQRAHRHRGVLRHVEQLQAARNSGKLANHVAKVHHHQQHHHHKGDAQPELLADQV
+AQPLAGHHPHAGAHFLNHDQRQRHRQNRPQQLVAKLGSRLRIDKNSARIVIDVGRDDPRP
+QHRKEQKNPGSPALQHRVDSSLVCQLNSERA*
+>PROKKA_00272 Divalent metal cation transporter MntH
+VCEGLGFESGVDKKFSEAPFFYWLYTLLIVGGAAVVLIPHFPIIEFSIFSQMLNGILLPI
+VVVFMLLLINRKDLMGEYTNSRWFNAVAWVTAVVVTVLSVVLMVQSIRQV*
+>PROKKA_00273 hypothetical protein
+MPNQCRHVRANGVQCRAHRVWKEDYCFFHLHHRTPNGTAKRSEDPPPPPPKNGIEIPLLE
+DLASIQIAIGRVLTALAQGKITSAEARTYLYGLRLAASNVKQKDFAPVNTVETYVQYDNG
+DTLGPEQFHAEKQPQHPLMDSGLLALRHLSNRLTYEATLDAYLTQGQEPPSTLRPPVAGP
+PADKSELQNWIKTGWKACQSRAHALELARKAIDQPIPDPIDPKAAFSINANIQRTA*
+>PROKKA_00274 hypothetical protein
+MEKPTVIHSSFTLERSYPYPAEKVFAALADPEKKRRWFADSPNHEVVKFAMDFREGGAER
+MEYRFNEGTPFPGVMLVNSGHYEDIVPGRRVVLCSTMTIAGRKISVSLVTFDLLPQGEGS
+ALLCTFQGVFFEGADGPEMRKAGWEFLVERLGEEVAREG*
+>PROKKA_00275 HTH-type transcriptional regulator
+MRKRKPKVDRIFHALGDPMRRVMVELLRKRPYSVSALAEPLGITLTAVGQHLKILEEAGL
+VRTEKLGRVRTVQLEPEGFAVLEAWAAEHKGEWALRLDRLGDVLADDG*
+>PROKKA_00276 hypothetical protein
+VTTANTFRANWPFVLIAAIFLGTALVGALTGRIWLQMRTITRTNDKVMYWATIWCSVIMA
+GFMLLVAAHYAPVINLIKEL*
+>PROKKA_00277 3-phosphoshikimate 1-carboxyvinyltransferase 1
+LHLSVSERTIAPARNIEGSLRLPGDKSISHRYALLSGLAEGTSRFTNFSTGADPSSSLAC
+VEALGAKVVRGEDGSVEVTGVGGQFQPSSSPLDCGNSGSTMRMLAGFLAAQQGEFTLVGD
+ESLSRRPMERIRKPLMQMGANISLTEGHAPMVIHGIPLKAMEYATPVPSAQVKSAILFAG
+LQASGTTTVRESVRTRDHSELALRAFGAELERTIDSITIAGGQKLSAIEAKVPGDISSAA
+FYLCAAALFPGSNLVFDDLGMNPTRASLLDVLTALGAHIGVIDLEDKASELIGTVKVNAP
+PDGLTGTTVSGALAAQLIDELPVLAAIGPYTNNGIRIRDARELRVKESDRIDLVVKNLRA
+MGAEVEEFEDGLDVPGGQTLHGAEIDSGGDHRIAMAFSVAALRAEGETLIRGAECASISF
+PEFFDLLDAIAQR*
+>PROKKA_00278 hypothetical protein
+VNVLRKSFVVAVVLLSFGASAAVAQTTVAASVYGAFRSSTRTGGISNFTVENPSNAAGFL
+LELRHISNPLMGYELTYSYHRANEAYSNTLKVLCPISPGGSCPEQITTAGVSANAQEVTG
+DWVVSFPLANLKPFVLVGGGVIVTSPATGSVTATITDFDPVTNMMSQTTSSMPTQTQTKG
+VFQYGAGLDWTVLPHIGLRFQYRGNVYKAANLTKVFTSTDKFTQTAEPVVGVFFRF*
+>PROKKA_00279 Phosphoserine phosphatase RsbU
+VYESRPQTTPEQHSSSIEGSHPTDAAAAAGSRSVELAQTDFLLRLTDALNTTLNLQTLLQ
+RTADLVRTVIDYRIFAILLLDNRTNDLRMRFQTGHRPEVERMRIRLGQGVTGQVALTRKP
+MLIPDVRDVENYINANPDVHSEIAIPLIVKNRVIGVIDIQSEQPNYFQPDHLHLLTLTAS
+RIAHAIDNARLYTRVSRQAQTLEVLNEISRDLSSILDTDRLFERISQLLRRLFDYQMFTI
+WTVRPIEHVLENRFALRFGERYYPNETIPVERGIVGAAIAERRPMNIPDVRRDPRYHKVN
+EETRSELAVPLMYKSKVVGVLDVEHTQPHYFSEDHVRALTTLAAQIAIAIENAQLYQRVI
+QQEQRLDHDLQMAREVQLRLLPPSLPSRPHAEFAARFLPARTIGGDLYDYLNYDDQRGAL
+AIGDVSGKGAAAALYGAVVSGTMRSQASLKPSPAAMLQALNASLHERRLDSQYVAMLYTV
+WNDENLTLQIANAGSVQPIYCRSGEIETVPVEGFPLGMFPQAEYEEISLSMRPGDSVFFF
+SDGITDGENEAGESFEERLTDSIARHHHLPAEEAVNAVFEELQEFQGDCDRFDDETLIAL
+RVV*
+>PROKKA_00280 Hypoxanthine-guanine phosphoribosyltransferase
+MPDQTQFPPAESLRIRFTRDQIQSRVREMGRHIREDLHGESVVLVGVLKGAAIFLADLAR
+AINLDCTFDFVAVSSYKSGTRSSGAVQLIKDLTEPIEGRHIIVVEDILDTGVTLSFLQSH
+FERHNPRSIRVAALLDKPSRRIRPIQGHYIGFSIPNEFVVGYGMDYAERYRNLPDIRILD
+SIPAS*
+>PROKKA_00281 Prolipoprotein diacylglyceryl transferase
+MYPFIHIGHFTIPTYGIMMWLAAVAGCIVLYRNFKRWKVEGDAITIVAFATVIGIIGGKL
+YHVLEKPVLLMHHPALLISRSGFAWYGGMIAGILALLFQAGTYNIRPLRMLDLCVPSAAL
+GYGIGRLGCFFSGDGGYGPPTKMWFGMSFPHGTVPTTQKVYPTPLFEFVAAVIIFYILWR
+RSRPAAERKLGHMTAEYLLLAGGARFLFEFIRINPKIFLGLSNAQWASIAEMLGGTALLW
+WSRKYASTPQPGQQGRQPKEEPALVAAGDSGGPPTAEQTQ*
+>PROKKA_00282 hypothetical protein
+VSACSHRPDARPLRIGQAQKDLRIPANKLHQEASPAGPQQILGRHLSQLPRRPRPAPPPE
+DIEDNAGPDKLKNRRRIHFLCCRHNSVRIAHPEPHLRRNAVIPVSGQLASNAPDSVPQRR
+RGHAQIQHPQGTNLIGPGLEQQRQNPGNHPAKPGKPGPADQQRWMMHQQHWLFQHMVELC
+AHHSSHRRKGDDADRIGINLPALEVLVKEVAPDHRGKPHHDAVCANR*
+>PROKKA_00283 DNA polymerase I
+VRLAQDAPVSFDPDTFKVTPPDPAVITPVLAQLEFNQLLNQFAAPPPKADYRRLSDPEEI
+EDFLKPVARKKRLAIDTETTSIQPMLAELVGVSLCHQAGEAVYIPVAHNLTPGQSQADKE
+AVLQTLAPVLADPAVTKIGQNIKYDLIVLGRCGMEINGPLFDTMVASYLLNPGKTSHNLA
+SIAAEFLGRSVISYQEATGGKNRPFADTDLDQATDYAAEDADVAWQAAQVLEKKLAESHL
+DGLFRDLEMPLVPVLARMERNGVGLDVQGLEDLGKELAAKLDEIERTCYRLAGHEFNLNS
+PKQLAQVLFEELGLTPVKKTKKGKTSSTDVSVLTVLAAKHPLPAEVLNYRTLSKLKSTYI
+DTLPKLVNPQTGRLHTSFNQAVTATGRLSSSDPNLQNIPVRSEIGERIRACFIAEKGNLL
+VSADYSQIELRVLAHLSRDPLLVEDLTKGLDVHTQTAARLFDVMPELVTKPMRARAKTVN
+FGILYGMSAFRLAREQGISRKEAQQIIDKYLGRYQGVARFQEENLRQAREKGYVTTLLGR
+RRYLPAINAGDRLARQAAERMALNTPIQGTAADIIKLAMLAAHRLLEERFPQALMILQIH
+DELLFEVPASQAEDLAQAVKQAMEGVIELAVPLVVDIGIGPDWAQAH*
+>PROKKA_00284 hypothetical protein
+VDHALLDRHFPRYTEYDPQVPVWDLTPQCPGAFHRFFDTSPLSPSGRYLAVTRYQPERLP
+EPGEAAEVVLVDLHTGKSQVIWESRGWDTQLGAQVQWGATDEQLFFNDMDPADWQPFGVC
+YNPLNGTSCRLAGTVYMVSPDGKQAVSPCS*
+>PROKKA_00285 hypothetical protein
+MAQPYEGLVGTSGRVQVNRNGRPAFSISTGAFADGWRGASLTPAKVGETTDGVCLGKISL
+PDKLTIASALRATAAGKAMELRYTLTPKADAKLNSLHVSFGLPASFLKGASYTIEGETKE
+VPAVLGATHLRAGDHVPSVRFTWPNGDWLQVDILSKTPVLFQDNRQWGDSFDLRLGPQMV
+PAQTLPANQPVEIAMRVSAKDGMKLDFDRPVTITAGKDWVPLDLELDIEPGSALDFSGLG
+QFDAPSGKHGWLQATPDGKFAFADSLDTPRRFYGVNLCFTAQYLSHDEAERLAERFLRLG
+YNTVRFHHHEYPLIDRKNGCSTDLKPESIDQLDYLFAQFKKRGIYVTTDCYVSRPVYASE
+IWDGAKGNVEMNEFKMLVPVNERAFENWKTYNRNFLTHRNPYTGMRYADDPTLAWLSMIN
+EANFGNYIRSVSDRARPDWERAWGAWLKARYGSAEAITKAWGSTFDGDLSKPTAKLAKSF
+TDDNRQSRDFAVFLADTERTMFLKMKKFLREEIGTKAMLTNMNGWTNTPQSQLARAEFDY
+VDDHFYVDHPQFIEKSWRLPSRCPNTSPVLAGAPGGRGTAFNRLMNKPFTISEYNYSGPG
+RYRGVGGILTGCMAALQDWSVVWRFAYSHRRENVLKPSTAGYFDMATDPLNQAAERASMC
+LFLRGDLDPAPRSAAITLNPETLEKGDSHQGRTPPSWDELVPVIQVGTFLGDRQSKVPAD
+IALPTTDAAPAAADVVMPKPYDSGKGSAILKELRAKGWLDAANKTDLDRKRGQSASDQFL
+MDGEKDMMVLDTPRTAGGYAEAGQTIHTQAADFSILDTGATVWISSLDKQPITSSKRLLL
+THLTDLQNTEVRYAERGRKTLLAWGKLPHLVRVGEAKISLHRSGAKLPKVYVLATSGHRL
+GEVPVTKGKNGTLELAISTKGEAGAQLMYELDFR*
+>PROKKA_00286 hypothetical protein
+MERSSLALPCSGGSCLHAAVRAQMTMQRTAFSLSIALSAVLASALLVGIVPLLRGGDNYE
+LAVKSALLVLVVGYAWLHWRAVTRRGRCLLKAAFCLNALVLVPLGATAALCHVFGGPKIV
+PREAGAIGGAIAILAAAAAAMQVILLTRCRTIELTVPKGD*
+>PROKKA_00287 Beta-lactamase hydrolase-like protein
+VYFRQYKVEGLGCYSYLIGCPAAGTACVVDPERHTGQYIQTAEHQGLRITHVFDTHLHAD
+HITGSAELAAATGATICVHPAIGAEYEHEDLLDGQHYRFGAAELEVVETFGHTPNSVSLA
+LTDHGRSEDVFALLTGDLLFVGDVGRPDLAGADLLEEQIHNLYESLYTKLGRFPDWTEVY
+PAHGEGSLCGKGMSAKPMTTLGFERLNNPLLADLEFAEFHRIMTEAFQVRPDNFAAIVAK
+NQRGPQLLREAPAFMELSVLQAERALAAGAQIVDTRAQSAFGAAFLPGSLNIGVSPSSVN
+WLGMLVPADTDIIIVADSKDVACQVADQFRRAGYDRLIGYVPDGVASWALQGKPMDHLPQ
+LTPASLKHVVGRYGNHVILDVRTDAEWATGHIEGAIHLPLPRLVREGIDLGKDRHITTVC
+RSGYRSNVAGSFLKSQGYEHVFSLIGGMTAWQAANR*
+>PROKKA_00289 Transcription antitermination protein RfaH
+MSISIASQPGLTWHPAYCRPRTEKVVDDYCKRHDIPCYLPLLRQRKRYQRRTVETYLPMF
+PGYVFVQLGPDTRTTFLECHRIVHIVEVREAQERTLVAELTELQHLETAQATVDLEVMPD
+IKPGTQVTITDGPLAGITGVVEKRKGKTRVTVNVELVGRSVVAEMDLGELELDGDA*
+>PROKKA_00290 Phosphoenolpyruvate-protein phosphotransferase
+LSDSSRTSSARNEPGETVLAGTGVSPGTVIGKAVVVGASVVSVREHELPVSQLEDEVGRF
+RAALEKSRRELEELRDRARDEKNQDLVDILEMQVMVIEDGMLDQEVSDRIRDTRRNSGFV
+LKNYVDEFCDQLVKAGSAFFAERTNDIQDLAGRILRQLLGSESVDLSELPEPCIIIAHDL
+SPSDTAGMDRDNVLAFVTAMGSRTSHTAIMARALGIPAVVGLGESLAQVGDGVRLVVDGT
+QGRVVVSPENATLVKYHERIEQEKAWRAKLEVNALLPAETRDGFHVSVAANVELPEEVER
+IRRVHRVGIGLFRTEFLFVKGGSISDEEQQYAAYRRVAEDVAPHSVVFRTLDIGGDKFLS
+HLDVPVEINPFLGMRAIRFCLRREDVFRSQLRAILRASAHGGVRILFPMITTMEELHATL
+AILDDVKAELERQGIPHNPDLDVGIMIEVPAAALIADKLAPHVDFFSIGTNDLVQYMMAV
+DRSNPDISYLYQPGHPSVVRLLDRVVRAANEHGRWVGICGEMAAEPLFVPLVLGLGIHEL
+SMSPVAIPIVKDLVRDINMLEAEELVDQAMACGSAEEVTQLCRSFVERIAPELFLD*
+>PROKKA_00291 Phosphocarrier protein HPr
+MVGTSVTLLLRFAPWRGSFFLYFQALAIDTGERGTDTPGSAPMAQLQTRTTQVIVQNQLG
+LHARPVTLIVKLAKTFSSRIAFERGGTVSDAKSVMALLLLAAGKGTELTITAEGHDAEEA
+IEALERLFSDKFGEE*
+>PROKKA_00292 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
+MNIYVGNLPYSAGDDALRTAFEEYGSVDSARVIMDRDSGRSKGFGFVEMGNDDEAKAAIE
+GLNGQDLDGRALTVNEARPRSDRGPRRGGGGFDRGPRY*
+>PROKKA_00293 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
+MNIYVGNLPYSVSDDDLRTAFEEYGAVDSARVIMDRDSGRSKGFGFVEMGNDNEAQAAIE
+GLNGQDLGGRPLTVNEARPRADRGPRRGGGGGGFDRRPRY*
+>PROKKA_00294 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
+MNIYVGNLPYSVNDDELRGVFEEYGSVDSARVIMDRDSGRSKGFGFVEMGNDTEANAAIE
+ALNGQDFSGRPLTVNEARPRADRGPRRGGGGGGFDRRPRY*
+>PROKKA_00295 Alpha-amylase 2
+MKPHRLAIFLGTFPMLFSLLLAGEGTMKEAGKSLRFGNGRLILTFDRDTGIWTGLEASGG
+AVCFRRTADSPSLNVQVDGKPVFGADRKMSLREQKVVQLPTASRLELTMGQGDWAVTAAY
+TLWDSGTLQRQATFVYSGPKPEGDHEVRNALFVLPDVGLAGTDAFWFATAEYPPRDHPFR
+HTDSGRRFGFPFSESTFHGFLARDPQAKLSLVSAYYTEDERAKLLVQEGKGTATAFHTHL
+LAETLRPGLRFEVGSQLLRVVPGTRQDALRALQGFYDLPGLRTKIGMPPDTGRQIFYSAH
+PGGTIDSSFRDVGGFANFTKLLPSIRDLGVNTLWLMPFWYGPVYAPYDYYRLDPKRCGTP
+AELKALTDKAHALGMRVLGDLIPHGPREEPGAKPSFAEQHGDLVCRDKDGKMIQWWGCHY
+CDYANPGWQDYMAKHAAYWVRECGLDGYRVDVAAGGAPNWRPYDHNRPSFSGLHGGLALL
+RKARAACLKENPNTIFLAESTGPTMYSAVEHGYHWAFSTLLEDHVLKDAPADFVQAMSGY
+LENQTYAFPADAFPIRFLTNHDKLRARYRYGPNLHRTLLALCAFMKGAPLLYEEEEMGNE
+DFIAKLYRIRQTYDELSVGTVSYRSIPVEPKHVFCIEREYKGKRSVVLINFSNQMSEVKL
+SLPKSDLKNPGIYEAVSGQRVDYAQDLTQSLDPYAYAVLVIRQRDELPPSVPKERGESPA
+APDGRAMDIKITQEDSLTRVSTPLYSAVIDSARGGLLQEVRGADGKLLVNGVELKEGRRK
+LFVGHDSVDFADCSVPLRILARDRQFPDGGKVSLLRGRAELRDGDGHAWMDLTVLYSLRA
+KSLSLNVSLTPQYRLSPSKSDLGMKIHFVPTTHWFAETAEGNLLGHVIRRHPASHGFSGR
+YWHGAGEAFFNGSLYPVVGEFGVLDTNRRIALGSMALRLDGAPLPVRLLEDEPPGSPVVL
+GGPAAATADIPLLRGSQRAVWQQGKAKGMVVTLDFRSVPARFTQYPDSFGVRGWDTGTPK
+LCYRGGWCTFGPEYLFRGYGMRATVVRSHGGELTALTDAAGNGLRVTDARFYTDQGLFGD
+WRDPRGVLRKMSASNVNDPEPDTQLLHLFEGPQDSAPLRFRSFFRHPHAGGRSLLNPRVE
+YEISYTPPTEKGKGLRIDCGVRPHLVKIGTGGFLAYKISLGGCDQWQVDGGEWQPLPAKG
+GRLWENKEAGHLPKTLLLRNSKTGLWTRFSDFVGGPDQVENVFLHAGQGQVHLFVAFYDA
+EPTDVRPVWRRAAFTMQAGGKQ*
+>PROKKA_00296 hypothetical protein
+MRIATFLLPLLVAIAGAAPKVETGTDGLRVRTARYVATFSTDSGLLASLALVDGTPLLTS
+PRLYADVLPDGRKNFSAKAKAAPKAKPQPDGSLLVEVAGALLDKDGKPHPTYPFTYTASY
+RFDDTAQVRVSVSVIPGFDSDAVFGFLGQVLSTASQREFFVNTADGLISEMAATHSGRTY
+QSESEPLDLKDPYLGVLLKTGQILQFRLVSGAESLLNVFFHDSGAGPTHLFLCPLSGSNP
+RQAKTGKAWQQELVIEAMPLAEWTKSR*
+>PROKKA_00297 hypothetical protein
+MRWQRAMLFVAVLVACGGCSWRGKPRANHVRMYCLVDLEPVAEKLIQGFTESQGVRVDVR
+YIRPDELNKRLQRDEYVGLFLYANTWSGSAEENLLRARGNGGGRPAELGRFTPCLIVPKG
+NPKGIRSAFDLGKPGMVHGRTRQGACLLARISESGYRKPPKGPDTEPSNIRVRDTDYDVA
+RLVAGGSIDGAVVWSFTQSAMADEVEEVESKGLKRYGNVQHMVVGTPMSTPQPGLVKAFI
+EFATGPDGQAILRKTGLDVDPKCR*
+>PROKKA_00298 hypothetical protein
+MTAFPRTDVGGVSVSRLIIGTNWFLGYTHSTSAQSRTNSERVNHRDVVAGIVETFVEFGV
+DSIMCPHTDTVIPEAIEEARQRTGKPLVVISTFALPVTKRTALDGFDLGEVERILDEQVA
+RDVDIAMPHQSVTDIMLDKCSREIRQMAPVCALIRDRNMVPGLSTHAPETVIYSDETGLD
+VESYIQPFNLMGFLMQVEVDWIARIIQNAKKPVMTIKSMAAGQVRPFQALTFSWNVIRPQ
+DMVTVGTSSKHEARELCEMSLQILDRRATTQELQRTRSKASISPA*
+>PROKKA_00299 Aminodeoxychorismate synthase component 1
+VKPASVLLATPDGEGFYRFSDPVRVVTAGSLEEVLPTVTAVEAAVAQEGVFATGFVSYEA
+GPAFDRALAAYPPGEFPLVWFGLYRNREVVPKTEMQDVPPLAWRPCLDQDEYVAAIRRVR
+EYIEAGDTYQVNYTFRLHAPFAGDPEALFARLASAQACRYAAYVDTGRYVVCSASPEMFY
+TQNADVFRSRPMKGTRPRGMTLAEDRAHREELLESEKDRAENVMIVDMVRNDLGHIAEAG
+TVHVPELFSAEPYPTVWQMTSLVEARSRAGFGQTLKALFPPASITGAPKPRTTEIIRELE
+TTPRHIYTGTIGYLGPEDARFNVAIRTVLIDRQTQQAEYGVGGGIVWDSDPLAEWEECMT
+KTRVLRTVRPEFSLLESLLWTPDEGYALLDRHLARLCDTAEYFGYPVDVVSVRQKLEELA
+GNLEPVPNKTRLLVDRHGEITVEGSPLGPAPDALVWRVCVHPERVDSHDPFLYHKTTHRA
+VYTQAAAAHPDCDDVILQNERGEITESCRANVVVEMPEGRFTPPVSCGLLAGTQRAELLA
+RGEITEKVLTPEDLYAATKVFLINSVHGWVVAELSDSSD*
+>PROKKA_00300 hypothetical protein
+MTQGLGPGLVSPAPFGAEEKPRGGLGEMGAFYAKGVTYWRSVTTP*
+>PROKKA_00301 Phosphoenolpyruvate carboxykinase [GTP]
+VKAIDGLEELQLTTNGHTVHFDNYYDQARKKEVTKYLVPADVELDKNLNQMEREAGVKEM
+DDLQRGSYKGREMFVRFFCLGTTGSSFSIPCLQITDSAYVVHSEELLYRRGYEEFKRQNA
+ADPNFEFFKYLHATGEVTERMTSKNVELNRVYMDYTRNCVRSVNTQYAGNTVGLKKLSLR
+LAIRKADKEGWLAEHMFIMRCNGPNGRKTYLAGAYPSACGKTSTAMIPGENIVGDDLAYF
+KVIDGEFRAVNVESGIFGIITDVNSKDDPVIWDVLHTPGELIFGNILVKDGKPYWQGMGE
+DIPATGMNYCSTEWTEGMEGPDGKVASCSHKNARYTIRINDLANKDPEWDKPEGMPMGGI
+IYGGRDSDTNAPVREAYSWEHGVCTMGAMLESETTAATIGAEGVRKWNVMSNMDFLSMSV
+GRYIQNNLDFAKDIERPKVFGTNYFLKKDGSYTNGKLDKSVWVKWMELRIHGEADAIDAG
+YGLIPKYEDLAKLFKQVLKEDYAKEDYAFQFRVNIPALIAKLDRMEEIYSTKVTDTPEIM
+KAEMKAQRERLEAIKAAKGEIVSPFDLD*
+>PROKKA_00302 hypothetical protein
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+>PROKKA_00303 hypothetical protein
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+>PROKKA_00304 hypothetical protein
+MTTPDINFTDLLQFLFMGIQRGSIYAMVAMGVV*
+>PROKKA_00305 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor
+VKRTLLSTAIAVLFLLSAVSVYAAQKKPYKVGCVFAITGGASWLGGPERNTAEMLAKQIN
+AAGGINGHKLELFIEDTQGDNTRAVNAVKKLIKKNHVCAIIGPSRTGTSMAVIPIVQQAK
+IPMISCAAAESIIAPVSKRKWIFKTTQNDSDAVRRIYENMDKKGIHKIGIITGTTGFGAA
+GREQLKALAPHYKIKIVADETYDPTDTDMTAQLIRIRNSGAQAVVNWSIVPAQSIVPQNM
+RQLKMKIQLYQSHGFGNIKYVEAAGAAANGLIFPGGRLLAADTVSASNPQKAILMKYQKE
+YEAAFKEPPSTFGGHAFDAISILAKALKKVGDNPAKLRNVIEHTNFVGITGVFHYTKTNH
+CGLNQNAFEMLTVKNGKFVVLHQ*
+>PROKKA_00306 acetolactate synthase 3 regulatory subunit
+MKISQLSIFLENRSGRLARIATVLGNAGINIRAMSLADTSDFGILRLIVSDTEQAEKTLK
+DQGFTVLISAVVAVAIPDSPGALGNVLSIMEHAGLNVEYMYAFVEKDMGQAIVIFRFDDV
+DRAISTLIENDIAVLESKRVLRL*
+>PROKKA_00307 N-acetyl-gamma-glutamyl-phosphate reductase
+MIRVGVAGATGYAGAELVRILAGHREVRITALTSRQYAGVPFAKVFPALAGVVSNECEAF
+DVERVCGQTDVIFTALPHKLPMAIVPGLIKNGKKVIDLSADFRFSDVRLYESAYQPHSSS
+DLLSRAVYGLSEVYTDDIRKADLIGNPGCYPTSTLLPLVPLLKNRLVDSGGIIVDSKSGV
+SGAGRSPSLTVHFSEVNESFKAYKVAAHRHEPEIESILTKSAGTPVDITFVPHLVPMTRG
+MATTIYAGLAGNVTKHDIAACLCDYYAGRQFIRIDRDGHPPDTRNVRGTNYCDIAFVVDE
+NNRRLILMSVIDNLVKGAAGQAVQNMNLMMGFEETAGLSAPPFPV*
+>PROKKA_00308 hypothetical protein
+MSRSFKSAGRMADPSDVAADICPVPAFIPDLMAVNGLADAGFSRLIFFPGMLFGSTEKWW
+GDGGVRPSAHEGLDLCFFETSDGLRYRLDETVSVPAAFDGKIVRIMDDLLGRTVVVQSRC
+APSDAPFYTFYAHIRPDNGLRQGDTLAAGTVFAAIARIVSPKIRLPAHLHITLARANDLP
+PVDTLSWPVMNRLDRSVFLNPLDLLMCDYAIEDDTRFTPGSDAVKPVRRIRQDRKGA*
+>PROKKA_00309 tetratricopeptide repeat protein
+MGLFSIFGGKPPEELERRGDFHYEAGAFGDAKMAFEKAIDRIERRFPEKKHLLPRIMEKY
+HLARNALAKMHVENGDHMITVRDYEEAGALYRLAMELTSDEAFAAEIHGKIAKLKDLIAD
+EDEPEMEWVGDAREEAYVDDWGGAEEDAGGAEDDDAYADDDMTADAEGMADETDADAQLY
+DSPENLFHVLVSALPEAVQDAYLGYGEAFAAGYIALNHGEFRKAVKELSRALEENASAKT
+LIPVELATAYMHLNDPDHARQILEDFLKENPGEIRGYQLLCEILWEAGNTADARNLLSGA
+PNDIQTTRPMQMLQGETLFQVGLYDEAEKVFTRCLEIHGKDEIVNRGLAKTYEAKGQIEK
+ARDLYADILNRCIMCGSAADPIIKRRYADLCIKSGDKSLKLLELYFGLAKEDPDNRADYF
+FRIADLYEAQGKDIEARKYRKLSTQAGGGKRPQ*
+>PROKKA_00310 Patatin-like phospholipase
+MNPIEAISHTGRSVRSRLKGFPRKKVLVLEGGGMRGIFTVGVLQAFSERGYAPWKTIIGA
+SAGALSGVVYAAGQIHMARDAFFTELISGRFIRMSNIFRPEKHILNLDWLVDHIIGGDEP
+LNIRRLRTTACPVLITVTRFSRDFPPDTLYLSTKTDSVPQALKATAAIPFFYRGFVHYRN
+DLLLDGGVLDSVPFKKALSMGFPERDILVVLTRPKGYRKERDSFWIKTLYESYYKDSQYR
+YLVNSLEHHFGNYNRMLDDLETNYDFDIIYPPDNFKVNRLTRSEDKIVDGFEQGVAAAKA
+YLKPKS*
+>PROKKA_00311 putative periplasmic serine endoprotease DegP-like precursor
+MRKKIHLFLVIGCIVFCFSPAVFAKTGGPKVLHYPREDAVVRAVKLVSPAVVNISTQYEV
+RTRVNPFANFGANDFFNNFFDQGIERKEKLTSLGSGVIIDGRRGFILTNAHVVVRGAKIT
+VVLKDGRKFHADIVGIDPESDLAVLKIKTKSPLPSIAMGNSSDLMIGETVIAIGNPFGFS
+NTVTVGVVSAVDRSFRIKNRIYRDLIQTDASINPGNSGGPLLNIDGQLIGINTAIYKNAE
+GIGFAIPINRAKKIISDLIKYGEVVPGWIGLSVQNLNSRLAAYLNLPQHSGVVVRSVDPS
+SPAGAAGIREGDILLAIDGHKIESIDDYKTAMRGYRKGQHAVVKIDRNGRHLTLSVRIEV
+FPESLAPELVQRLLGVKVVGIGQKVRFNQTINADKGVIISEIDPQSSLAGIGVRPGDVIR
+KVDAEATNTVQSFYKAMIKDRWKQSIVILLQRGDQGYYITLKLS*
+>PROKKA_00312 hypothetical protein
+MFQFLLFVGSITAFIIGGLIVLIGIGAITGCAGGILAMCSGAIIAVLGAWSAITFFLPSP
+DPSVPARETINLIRRNGRWM*
+>PROKKA_00313 PHB/PHA accumulation regulator DNA-binding domain protein
+MHLVKKYANRKLYDTTDKQYITMEKLAELIKSGSEVMIIDNETGDDLTAQVVSQLLAREK
+NEDDTALPSSVLMQMLRKGRGTLFGYGKKYISLWQSAVLMSRDENEKLINTLVKDKELSE
+TEGRTLKKEITAYTNGLKTWIRENIDQRVNEALNMMNLASKEQVKELIDQVESLSLKVQS
+LEREIRRKN*
+>PROKKA_00314 Putative diacyglycerol O-acyltransferase/MT1809
+MRKQVEIMSSIDNFWLYMDHPTNLMIITGFLQFDKPINFERLKQTIKNRLLCYDRFKKRV
+IRPMTGVGNATWELDPRFDLRSHLHRVALPAPGDKETLQELISDLTATPLDPTKPLWQLH
+YIENCENGGSVLFARIHHCIGDGISLIRLLLSLTDTEPNAVWSDCLNEPKIEKETSFNLF
+PPLESAMKKVTRARRRAQKVTRFVSREIEKSFSNPYHIVKRTRTVTKFALDVATVMSKIL
+LLPADRKTVFKGELGVRKSVAWSDPLPLDDIKVIGKYFNATINDILVALVTGALRRYLQQ
+CNNLVGDLDIRVAMPINIRPIDGDIELGNQFSLILVALPVHIDDPVLRIREVQRRINDLK
+EAPDAAVAYAVLNALGVSSAKLAKTAATMFANKTTGVFSNVPGPRQQLYFCGEKINNIMF
+WVPRIGGLGIGISIISYNNEVSLGIATDSGLVQDPKAILDHFANEFRMLLGMYKAGQMEK
+EPLVINDRSVEPPVFAFNTEKIASVQAIRCKAITRSGTQCHNRAATNSMYCTLHLSKYET
+IASREENDMPAEADNTLPAEDQAAG*
+>PROKKA_00315 cell division inhibitor MinD
+MNAPAPTPNNPRIVVCCGSGGVGKTTISAAIGLCGALMGKKTVVLTIDPARRLADALGIS
+ALNMEAQRVPLEASVPASGELYAMMVDAKRTFDRLIGRYSSAGLRDRILENRYYQHVSNN
+MAGSHEYMAMERLYEIYHEKRFDLIVLDTPPSRRALDFLEAPQRVINLLGHPYFLKLFKP
+YIKAGQLSGRLFNLLAMPVLRAVGQVVGGQTISDIFSFFQLFNDMLFDGFSKRASAVESL
+LSDPMTTFFAVTTPQEYPIQEATYLFRQLQQRNMPFGGFIVNRVHSDTADSPFDSEAADR
+KRVLMEKIADKPIFQRLEIADRMDRKLARSDAAAIDRISSISPGLAVFPILFADETVNDI
+SGLRVISTQLMKHPEFKI*
+>PROKKA_00316 Arsenical pump-driving ATPase
+MAKADESDRTQLEALFSIGAGVRSLDELLTRRLIFLMGKGGVGKTTLSVALALTAEMMGK
+RVLLTEIGDSQGIGRYFDAQPDVRPRQVSSAIWAARVDPKDELTAYLHYHMKSGFIANRI
+TQSRLFDYLLAATPGLKEIMTLARIWRWEKAKNKAGTPLYDTIIVDAPATGHGLSLLRLP
+KMLVEMIRVGPIASQVNGVQQMLLNPERTALTLVTLPEELPVNETREMIDIAVDEVGIPV
+QAVFINGVHPVFVTPDEFSRIQELDRDCPDADPDCPDLRFALDVARRQIVRNAAQQVQMN
+EVHAAAPGHVIHVPYYYTNDLGPEEIRTIAASLHRQISEAPRGGGR*
+>PROKKA_00317 PHB/PHA accumulation regulator DNA-binding domain protein
+MYQIKRYANGRFYDTVEKNYVTREQISKLLGAGKKISIIDTRTEKDITDDIVSRIKAKKQ
+NPSKSKKAGKSNKAVDDSTGMLVQLFRKGGDALFDYGKRYASMWQNMVTMSRDEVDKLVN
+MLVKDNKLTELEGSKLKKEIDRYRTNIQGWITRNIDNRVNEVLNRMNLANRDQILELTGK
+IEELNKRINRLGKEKKGPAKTKKTS*
+>PROKKA_00318 hypothetical protein
+MAKTATKKGETAQTKITGKIQKAAESVTDKVKGYNEKYVAKNIEKGKATLKEYNEKYLVK
+TVEKGKDTLKEYNDKYITKAVEKGRSYVDGPYKKLSGTMDQWLEKGRSFEKDAWKKMDGY
+VENGKKFMYKLPLVETVEKKVTSSLNSVPSVVNLPGKGDIEKLTLAMEALNSNIEALRKQ
+SAQ*
+>PROKKA_00319 hypothetical protein
+MGKTIRRALVLSGGGARGAFEVGVMRYLNEVNWQPDLICGTSIGAINGAAFGSGMSVDEL
+AHLWKTYHRKQMYKITFPAFFRTLLSGRKFSPLSDNRPTRSLLEKTIDIDALRNSTTEII
+ISVLNMRTSQVRYFTHKAIGIEHLMAAGGIPMMFPWQYIDGDPYWDAGVMVNTPIMPAFE
+RGATEIIVVLLSPLGAIPQRLPSTHREVSELVFEQFLIGSYTACLPNAGWRTNPEADVYD
+TPLPDSPQLQLSMKGVRMATVYPTRMLGFRSLLDFSPRQAKTLLRDGYVNARMQLKSFFK
+*
+>PROKKA_00320 hypothetical protein
+MPTATIRQQLIELLSENKYDARDLSQRLGVRETVVYDSIPHITRSVTSMGKKLKIVPSRC
+TSCGYTFKDRKRAAKPSRCPTCKSERIAKPKFYIV*
+>PROKKA_00321 3-dehydroquinate synthase
+VKTVSISGQTGASKIVIGERLENLSNYLPDRRIVVITDTNVAGHYGKMFPDVEVITIGCG
+ESIKTLDTAKMIYERLVSMAADRSVFIVGIGGGIVCDITGFIASTYMRGVRFGYVATTLL
+AQVDASVGGKNGVNFMGYKNMVGVFNQPEFVICDPYVLGTLPPRELACGFAEIVKHAAIS
+DKDYFADLEESHEKACARDPETLERIIRKSVVIKAGVVNADEKERGERRKLNFGHTLGHA
+IEKTLGVPHGEAVSAGMVMAAELSANRGHLPRPDIRRLKDLLTHLDLPTALPIDPERIID
+AMARDKKRQGEKIHFVLLSAIGAAFVDSISLAELEAVVTG*
+>PROKKA_00322 Phospho-2-dehydro-3-deoxyheptonate aldolase
+MLIVMRQDASREQIDAVIRAIEARGYTARSIPGGDRVSIGILNNRTAIDAAWFQDMPGVK
+ETIPVTRPYKLVSREIQPHDTIIRVGGVEIGNGHLVIIGGPCAVESEAQVMATAERVKKA
+GADIFRGGAFKPRTSPYAFQGLGEEGLKILARAREQFGMPIVTEVMDLEYFDMVEAYADI
+VQIGTRNMQNFSLLRRAGESKKPILLKRGMSATIDEWLMAAEYVLSQGNPNIILCERGVR
+TFVRHSRNTLDLSAIPVVQRESHLPIIVDPSHATGFRDQVIPLSRAAAAARAHGLMIEVH
+NAPDTAQCDGSQSLYPDQFETLCRQVRSIFRILGETDETR*
+>PROKKA_00323 hypothetical protein
+MILIDILRRNWYDLLPLNEIGNICAVKFGNKAADP*
+>PROKKA_00324 Fatty acid metabolism regulator protein
+MTNATNDQPFRPARFTEQRLITAILDGTCPPGSVLPAERRLAEQFGVTRPTIRETLQRLA
+AEGWITIRHGKPTRVNDFWETGGCS*
diff -r 000000000000 -r 68a3648c7d91 de_prokka/p1
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/de_prokka/p1	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,2474 @@
+>NODE_25#PROKKA_00102
+VVMEEYQKTLARLLAESGGLFFQEGLRLKDGRPTPYFVNLGVFRTGRLALELGRCFSLWI
+HHHGLDQDLDCIVGPSYKGSAIAQATAIALYELHGKEVAYDYDRKEAKTHGEATGHGYLF
+VTGAALQGGKVLIIDDVGTSMSTKLELLKKLSWLKPRLERPMELLGVVLAVDREQTQAVY
+DAQGRVREGVRGPDAMESFRQESGLEVWSLLGIRQALDYLYKEGIPVLIQGEMRPLDELT
+MQIAREYLELYGREEA*
+
+>NODE_17#PROKKA_00047
+MQVVQAILSKVHEAGDIYFAKYGGHYCVGCERFLTEHEMIDGKCPDHGTEPVYQEEENYF
+FRMSDYTQPLKEYIRANPDFIRPERYKNEVLAILDQGLEDLCISRPKTRLTWGIELPFDQ
+NFVTYVWFDALINYLSGLDWPDGELLERFWTGPKADPQHLIAKDILKPHGIYWPTMLMAL
+AKAEGRPLDHYLYRHLNVHGYWQVGEGKMSKSRGNVVKPLDLAGIYGVDPFRYFLLREMT
+FGLDASFSEDLLVERYNADLANDLGNLFSRVLNMLSRYRDGLLPELHPQELTEADREMKG
+ALAASLGPGAEHDFQAQVREFRFHTALADLWSQVRRANKYIVAREPWVMAKDPDRAAELD
+NVLYILVQLLASVTHLAWPVMPATAEKMAAMLGLELVVPVDWQRLFALELMTPGAKAEKP
+QALFPRVQTDKVKAKAARKEAKQAQQQPAAKGGGKQKAKPQDKAGLITIDEFAKVELRLG
+RVLEAGAIKGADKLLKLKVDLGEPEPRQIVAGIARHYRPEELVGRQVVVVANLKPAKLRG
+EISQGMVLACVAEGRVRLVAPEEELPPGSVVR*
+
+>NODE_3#PROKKA_00175
+VLACFYFFADSPMLNWSQIDTALLDMDGTLLDLHFDSHFWLEHLPRRYAELKHLDPEHAR
+QSLLSKIEQLRGKLDWYCIDFWSDLLDLDVVALKRETRDRIAWRPHSKAFLERLRACGIR
+RVLVTNSHPDGLNLKIETTGIDQHLDRLFSSHSFGQPKEGPDFWEQLAQQEPFDPERTLL
+IDDSLPVLESARRYGIRHLLAILSPDSQQPPRQPSHHPCVHDFDELFQSLDQFAHQKNRI
+DGLSD*
+
+>NODE_8#PROKKA_00285
+MAQPYEGLVGTSGRVQVNRNGRPAFSISTGAFADGWRGASLTPAKVGETTDGVCLGKISL
+PDKLTIASALRATAAGKAMELRYTLTPKADAKLNSLHVSFGLPASFLKGASYTIEGETKE
+VPAVLGATHLRAGDHVPSVRFTWPNGDWLQVDILSKTPVLFQDNRQWGDSFDLRLGPQMV
+PAQTLPANQPVEIAMRVSAKDGMKLDFDRPVTITAGKDWVPLDLELDIEPGSALDFSGLG
+QFDAPSGKHGWLQATPDGKFAFADSLDTPRRFYGVNLCFTAQYLSHDEAERLAERFLRLG
+YNTVRFHHHEYPLIDRKNGCSTDLKPESIDQLDYLFAQFKKRGIYVTTDCYVSRPVYASE
+IWDGAKGNVEMNEFKMLVPVNERAFENWKTYNRNFLTHRNPYTGMRYADDPTLAWLSMIN
+EANFGNYIRSVSDRARPDWERAWGAWLKARYGSAEAITKAWGSTFDGDLSKPTAKLAKSF
+TDDNRQSRDFAVFLADTERTMFLKMKKFLREEIGTKAMLTNMNGWTNTPQSQLARAEFDY
+VDDHFYVDHPQFIEKSWRLPSRCPNTSPVLAGAPGGRGTAFNRLMNKPFTISEYNYSGPG
+RYRGVGGILTGCMAALQDWSVVWRFAYSHRRENVLKPSTAGYFDMATDPLNQAAERASMC
+LFLRGDLDPAPRSAAITLNPETLEKGDSHQGRTPPSWDELVPVIQVGTFLGDRQSKVPAD
+IALPTTDAAPAAADVVMPKPYDSGKGSAILKELRAKGWLDAANKTDLDRKRGQSASDQFL
+MDGEKDMMVLDTPRTAGGYAEAGQTIHTQAADFSILDTGATVWISSLDKQPITSSKRLLL
+THLTDLQNTEVRYAERGRKTLLAWGKLPHLVRVGEAKISLHRSGAKLPKVYVLATSGHRL
+GEVPVTKGKNGTLELAISTKGEAGAQLMYELDFR*
+
+>NODE_3#PROKKA_00181
+MRWLSHSAFLFSHGRSAVKALSLLLLFSLGGCSAVNNMMYKTTGEVMVGYAKAHAVPYVL
+SSDDLGMSCAMSEALTPLLMSFGQVTAKPDQLGVMMQMSAGTCAEEKGWNAELAYMKELR
+NQHPQNAEDDMIVEKRHYIEAADRYYSAWKHLVAYYGDPSTGQCPTFKNDEGQFIYMAGL
+LAGVQALAAEIQSTSDEGVPKNIGSTVAQASGCLSDDKWWGVPMALRATVWSMIPGAKPD
+GENPFQRLDESDKKANKARVRLAYVLHVIAAWNKGDTKLVKKLIREQQAQEAKYPADPRW
+KMIDKLSTLYLRSISDRMWVEHTGHRTPIGGLGTFWDDSKGSGEVIDLDSVM*
+
+>NODE_3#PROKKA_00179
+MSEAIEQSSMYLQKRTIGGRSAREWFSSLPACILLMAVVLFTTSSDIHNKALQLGQVLWS
+GYYKLRVDPVKPDCNPNVNVDAQVKRQIAAQAAQQDSMLGSLVGSSPVNPAAVRQSVINA
+KQACEAQFADYNATKGRITEGVRVYRSVELFISDVVAFGLASQRYILALLVLVCAATATF
+SRHHIAMRGMETRLDHIVSHFMQFIANTMLLISSFMYRQMSHNSGAVVTTGQEISHDIWI
+AGFLLLTIVSLVQLFRVPEDAEEGGTLGHAFLCVPLYTTMCLISGTFFAFVGSPAGIGIY
+LDKMMELADQFLNVGLYVWAGMMLKQTRLASLVFNVLRPLKLPPELLAVVAVMVAAVPTA
+YTGASGIFVIAAGAVIYSEMRKAGARRQLALASTAMSGSLGVVLNPCLLVVVIAYLNREV
+TTDSLFHWGGWVFLLTSTLFLITSLVVNRQKGFKVAPMNEALPEMVMRLKPLIPYVLVIA
+GVVFFYWLLLGVTMNEFSAPRILPIIMVGILVYEHVHFRGDRNKVSGEVDHQGLEKSLRT
+ATSETTAEIGALLLLFGLSVSIGGVIERSQVMSLFPQALPSPWLAMMLMVVILVILGMIM
+DPFGAVILVSATIADLAYQSGIAPVHFWMVTLVAFELGYLSPPVALNHLLTRQVVGESEM
+NLSYRESGSFYQRHERVLMPLLVMGSALLIVAFVPLLFYAR*
+
+>NODE_9#PROKKA_00319
+MGKTIRRALVLSGGGARGAFEVGVMRYLNEVNWQPDLICGTSIGAINGAAFGSGMSVDEL
+AHLWKTYHRKQMYKITFPAFFRTLLSGRKFSPLSDNRPTRSLLEKTIDIDALRNSTTEII
+ISVLNMRTSQVRYFTHKAIGIEHLMAAGGIPMMFPWQYIDGDPYWDAGVMVNTPIMPAFE
+RGATEIIVVLLSPLGAIPQRLPSTHREVSELVFEQFLIGSYTACLPNAGWRTNPEADVYD
+TPLPDSPQLQLSMKGVRMATVYPTRMLGFRSLLDFSPRQAKTLLRDGYVNARMQLKSFFK
+*
+
+>NODE_8#PROKKA_00289
+MSISIASQPGLTWHPAYCRPRTEKVVDDYCKRHDIPCYLPLLRQRKRYQRRTVETYLPMF
+PGYVFVQLGPDTRTTFLECHRIVHIVEVREAQERTLVAELTELQHLETAQATVDLEVMPD
+IKPGTQVTITDGPLAGITGVVEKRKGKTRVTVNVELVGRSVVAEMDLGELELDGDA*
+
+>NODE_7#PROKKA_00260
+MQVYPKFLLSATAPAHFPPPSAPEFAFLGRSNVGKSSLINALLGSRQAKVSSTPGRTRAI
+NFFSLTTSPNRQQPNFLFADLPGYGYAKISKSISAEWPKVV*
+
+>NODE_6#PROKKA_00245
+MDPKTVIRELLTGTGVHLNGPHPYDVQVHDERAYERWLSEAELGLGESYMDGWWDCLALD
+EFIERILRAGLEEKVKRNFSTAFYVLSKRLFNQQTRVKSKRVGREHYDLGNELFSKMLDR
+RMVYSCGYWQRAKNIDQAQEAKLDLICKKLNLKPGMKVLDIGCGWGSFAKYAAEKYGVEV
+LGVSISKRQIELGNELCKGLPVTLLYKDYRDVEGKFDAVVSVGFFEHVGYKNYDTYMKIV
+DRCLTDNGISLLHTIGNNTTTHYVNRWTNKYIFPNGMLPSIAQVAKAAEPYFVIEDFHNF
+GPDYDKTLMAWYDRFNKAWKELKNQYDERFYRMWRYYLLSSAGGFRSRATQLWQFVMTRT
+GRQQPDCRFA*
+
+>NODE_3#PROKKA_00153
+MSSPVRTATFIGAISVVLWGTLALLTKLTGGRIPPFQLMSMTFGIAFLLMAVRWWSRGES
+GLGYIRQPFPAWLLGVGGLFGYHLAYFKAMTLAPAVDVSLIAYLWPLFIVLLSALLPGHS
+LRAQHLVGAVLALAGCWLLVGRNSQGFDWTYADGYLVAFGCSLIWSSYSVLSRLVRSVPT
+DAVGWFCGVTALLALGCHLLWETTVWPVGTLQWLGVIGLGLGPVGIAFFTWDHGVKYGNL
+PLLGTLAYSAPLISVVLLLLAGFGQASGMLFLASALIVAGSFVAGRAKHASPELAEEPVP
+E*
+
+>NODE_8#PROKKA_00284
+VDHALLDRHFPRYTEYDPQVPVWDLTPQCPGAFHRFFDTSPLSPSGRYLAVTRYQPERLP
+EPGEAAEVVLVDLHTGKSQVIWESRGWDTQLGAQVQWGATDEQLFFNDMDPADWQPFGVC
+YNPLNGTSCRLAGTVYMVSPDGKQAVSPCS*
+
+>NODE_3#PROKKA_00168
+MTAEWISVGLLALLVLAFVIDIGLRLRKPPQKPQPPVAERPPAAPEQREAVPEAKAPPPR
+PEAPAAEEKPAKAEPEAEVVEPEAEAPPAPPVAEEAPPVEAPPAETPAAEPEVEEAPVNW
+FARIKQGLGRTRGNFSEGLSNLLKGQKAIDDELMEDIETLLLTADVGVTATTEIIDTLTE
+KLERKQLKDGDALKQALREELHGILAPSTAPLNIDDGHKPYVILMVGVNGVGKTTTIGKL
+ARRFQDQGKRVMLAAGDTFRAAAVEQLQVWGERNNVPVIAQQTGSDSASVIYDAVQSAQA
+RGFDVVIADTAGRLQNKENLMSELEKVVRVMKKLDPEAPHEVMLVLDAGTGQNALSQAQI
+FQQAVGVSGITLTKLDGTAKGGIIFAIARQLKLPIRYIGVGEQVGDLRPFQAEEFVEALF
+DEPA*
+
+>NODE_2#PROKKA_00131
+MPQTKTTDLTYLVETYTEEMVSWAMYKVSDAELARDLVQDTFLAAAEKMDAFKGESSPKT
+WLFSILNHKIIDVYRNKVKQPVSFDSQVFSTYFNERGDWKKEKEPKDWHQEEKQLLDDSA
+FQQVLQKCLESLPEKWSTCVKMKYLSEKKGEIICQELGLNPTNFWQIIHRAKIKLRDCVD
+QNWFRS*
+
+>NODE_13#PROKKA_00035
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_25#PROKKA_00104
+MKDKRQAEDESAREPFTPEEQDVDKYKREVEELKAKLAAMEKEEQQDSSPAEEAPQEDEK
+KEE*
+
+>NODE_2#PROKKA_00140
+MKSLKGTRTEQNLLKAFAGESQARMRYDYFASQAKKEGLEQISALFTETSLNEKEHAKRF
+FKFLEGGPTEIVAAYPAGIIGTTLENLRAAAEGEHEEWTELYPEFARVAEEEGFKEVAAA
+FKMIATVEKAHEARYSKLYKNLEAGKVFQRDGVVVWKCRNCGYLHEGKKAPKKCPACLHP
+QSFFEVETFGY*
+
+>NODE_7#PROKKA_00277
+LHLSVSERTIAPARNIEGSLRLPGDKSISHRYALLSGLAEGTSRFTNFSTGADPSSSLAC
+VEALGAKVVRGEDGSVEVTGVGGQFQPSSSPLDCGNSGSTMRMLAGFLAAQQGEFTLVGD
+ESLSRRPMERIRKPLMQMGANISLTEGHAPMVIHGIPLKAMEYATPVPSAQVKSAILFAG
+LQASGTTTVRESVRTRDHSELALRAFGAELERTIDSITIAGGQKLSAIEAKVPGDISSAA
+FYLCAAALFPGSNLVFDDLGMNPTRASLLDVLTALGAHIGVIDLEDKASELIGTVKVNAP
+PDGLTGTTVSGALAAQLIDELPVLAAIGPYTNNGIRIRDARELRVKESDRIDLVVKNLRA
+MGAEVEEFEDGLDVPGGQTLHGAEIDSGGDHRIAMAFSVAALRAEGETLIRGAECASISF
+PEFFDLLDAIAQR*
+
+>NODE_4#PROKKA_00226
+MRPGEEDKDPLGDFLASLERLSALPENIRVLPSHGLVFEGLHQRLKALQRHHELQIDRLL
+ERCEHPQSARDVLSLMFRRPLDEHAILFAMGESIAHLHHLRLQGKLSQVEQAPFRYIRN*
+
+>NODE_1#PROKKA_00080
+MHPKLFACCTALLACCAFPALGTPAPGSANASSSVSGVMTINADHSSMANTTGQGTEVTY
+SGHVIVTRGALRLYGHSAVIHGRSNTIGKVVVTGTPARFELREPGKPHVLGEADSITYNG
+KTDILQLDGQVHFSRPGEHFSAAHITYRIATRQLEASGNGNGRVHAVLSPAARTSP*
+
+>NODE_2#PROKKA_00125
+MKENLEWHKVLEKKEDLPENRIITVNAGSKQIALSHFEGKICALDNHCPHQGGPLGEGSI
+ENGILRCPWHGWDYHPCTGKAPGFDDGVATYRVEERGNGIFVGIPPKKPHKTTLSDIMVE
+TMVHWGVDTVFGMVGHSNLGLADAFRRQEEKGKLKYIAIRHEGAGAFAASAYGKLKGKPA
+ACFSIAGPGATNMFTGLWDAKVDRSPILALTGQVATQVVGTGNFQEVDLVRAFQTVAAFN
+HRVQKDSKHAELMSLAIKHALLKRDVSHLTFPDEIQEILEGKEESQTPEGRMGELQISPA
+AGSMDKAVDFITKSKRPVVIVGHGARFVMEQIISFAEHLNAPVLTTFKGKGLIPDDHPLA
+AGVLGRSGTPVASWFMNESDLLIVLGASFSNHTGITPKKPIIQVDFDPLALSKFHKIDVP
+VWGELSTTVNILMKRLPVKPNTVDQRTELAQRWKIWRTEKQKRLLEDRGKGISSIAVFDN
+LSKLIHPEAVVCVDVGNNAYSLGRYFESKNQSFLMSGYLGSIGFAFPAALGAWAATRGKR
+QIVAVAGDGGFAQYMAELATSVKYNMNIKLVLLNNSELGKITKEQRSGGFKKFATDMHNP
+DFAEYARGCGALGIKVSKRKDLKTKMKEFLDYKGTALLEIVTDVLLV*
+
+>NODE_6#PROKKA_00241
+MEKKRKEMAFRFPKPDGLYNPANEHDNCGIGFVAHIKGEASHDIVERGLEVLRNLDHRGA
+KGSDNASGDGAGVMVQIPHEFIKKVLKIDVPAKGSYGTGLIFLPQLEAEANACVDILSNI
+IQEEGLQLIGYRDVPTDSSIPGEIARTTEPRIKQVFIKANLEEDILEQKLYIVRKRAEKA
+VQASDLSQKEVYYHSSLSAKTMIYKGMLTPDQMKDYFTDLQHPLFKSALILIHSRFSTNT
+FPTWDLAQPFRLVAHNGEINTIKGNRLWTQAREGLLKSEVFGDDLPKILPVLEEGKSDSA
+SFDNVLEFLHRTGRSLHHSLCMMIPESFNEKNPIPESLKAFYEYHSTIMEPWDGPASIVF
+SDGRYIGGTLDRNGLRPSRYVITKNDLIVMASETGVQDFAAEEILEKGRLRPGKILLVDT
+RLGIIIPDEEVKEQLSRRNPYGMWLKENRLLMEDIKVRQRVPSTMDDFLTYAKVFSYSKE
+DMEFLIQSMSNTAVEPINSMGNDTPAAIFSRQPQRLFNYFKQTFAQVTNPPIDAIREGLV
+MSLTNYIGSLNSNILKESPDHCKLIKFPDPIVTNTDLGKIKDLKDEMFSHEIISIVFPVD
+QGFEGFKKAFDEMLERAEKAVDDKKNFIILSDRAIDSKHAPFPSLLAVSAVHHHLIQKKK
+RMQVGIAVETGEAREVNHYALLLGYGASVINPYLAFAAVDHLVKEGKLDMEYKDARRNYI
+KSIKKGLLKIFSKMGISTVRSYHGAQIFGAFGLSKELVDKYFKGTSSPISGIGLEEIYEE
+YSQFHKDAFREEATQEKFRFETTGVYAWRKNREDHAWNPDSIGLLQWATRTNSYEKFKEY
+SRTVDEYNRKPSFIRGCFQVKRNSISIEEVEPVEEIMKRFVTGAMSYGSISKEAHESLAV
+AMNTVGGRSNTGEGGEDHNRFGTEKQSAIKQIASGRFGVTSNYLTNAREIQIKIAQGAKP
+GEGGQLPGYKVNEVIAKLRNSTPGITLISPPPHHDIYSIEDLAELIYDLKATNPKAKISV
+KLVSQDGVGTVAAGVAKAFADLIIISGGEGGTGASPISSIKHAGLPVEIGIAEAQQTLVK
+NNLRGRVKIQVDGQLKNGHDIVTMACLGAEEFGFATSALITLGCVMMRKCHLNTCPTGIA
+TQDETLRERFTGNPQLVINFFRFLAGEVRELLAEMGFKKFDDIIGRADLLEENKEVFGWK
+MKNVDFSAVLNRPAEADKFDIRYVPGSASLNLDGHLDHTLIEESGKAIKGKEKVWLHHPF
+ANTDRAIGAMLSGVISQKYGEFGLPEDTIHATFDGSAGQSFGAFLAKGVTFRLEGDSNDY
+IGKGLSGGKIIVVPPTGSTFTPEENIIIGNSTFYGATGGEAYIQGVAGERFCVRNSGMEA
+VIEGAGDHCCEYMTGGRVVVLGKTGRNFAAGMSGGIAYVLDEDGDFDFYCNKGLVELLEV
+EDKKDIKELQGLISKHLTYTQSPKAAKILTQWEEYLPKFVKVIPYEYRKVLRERELRELE
+QKMKMTEDANVMQE*
+
+>NODE_9#PROKKA_00310
+MNPIEAISHTGRSVRSRLKGFPRKKVLVLEGGGMRGIFTVGVLQAFSERGYAPWKTIIGA
+SAGALSGVVYAAGQIHMARDAFFTELISGRFIRMSNIFRPEKHILNLDWLVDHIIGGDEP
+LNIRRLRTTACPVLITVTRFSRDFPPDTLYLSTKTDSVPQALKATAAIPFFYRGFVHYRN
+DLLLDGGVLDSVPFKKALSMGFPERDILVVLTRPKGYRKERDSFWIKTLYESYYKDSQYR
+YLVNSLEHHFGNYNRMLDDLETNYDFDIIYPPDNFKVNRLTRSEDKIVDGFEQGVAAAKA
+YLKPKS*
+
+>NODE_4#PROKKA_00206
+MLRFIVALMLLFPLVAQAEDAIKPGQWKQTIHVTIPGSSVKIPPHSSTNCVKPEQAGSIK
+SIIEEAQQPGCKLNEYSRSGNKVHWKMTCTGKSQASTEGVFTLQSKTSYHIHMNALMQTP
+NGPYKTVVDSDGKWVGPCK*
+
+>NODE_8#PROKKA_00301
+VKAIDGLEELQLTTNGHTVHFDNYYDQARKKEVTKYLVPADVELDKNLNQMEREAGVKEM
+DDLQRGSYKGREMFVRFFCLGTTGSSFSIPCLQITDSAYVVHSEELLYRRGYEEFKRQNA
+ADPNFEFFKYLHATGEVTERMTSKNVELNRVYMDYTRNCVRSVNTQYAGNTVGLKKLSLR
+LAIRKADKEGWLAEHMFIMRCNGPNGRKTYLAGAYPSACGKTSTAMIPGENIVGDDLAYF
+KVIDGEFRAVNVESGIFGIITDVNSKDDPVIWDVLHTPGELIFGNILVKDGKPYWQGMGE
+DIPATGMNYCSTEWTEGMEGPDGKVASCSHKNARYTIRINDLANKDPEWDKPEGMPMGGI
+IYGGRDSDTNAPVREAYSWEHGVCTMGAMLESETTAATIGAEGVRKWNVMSNMDFLSMSV
+GRYIQNNLDFAKDIERPKVFGTNYFLKKDGSYTNGKLDKSVWVKWMELRIHGEADAIDAG
+YGLIPKYEDLAKLFKQVLKEDYAKEDYAFQFRVNIPALIAKLDRMEEIYSTKVTDTPEIM
+KAEMKAQRERLEAIKAAKGEIVSPFDLD*
+
+>NODE_2#PROKKA_00116
+MGVNLLDIILAVPLIFFGYHGYRKGLIIEVTSLAAFILGLYFAFYFSNFTAGILKEYFTI
+QTKYMAAIAFVVTFIVVLLIVLAVGKIVEKFIDILLLGFLNKLAGGLFGVLKGALFLSII
+IFVINYFDASHSIIKQKAKDNSVLYKPVESIAPALYSWLHLKNFDFHLPSEESVIKTITH
+RANPD*
+
+>NODE_1#PROKKA_00089
+VTDRTVRTWIGEAVAAAAADGVTFSVPVTPHTFRHSYAMHMLYAGIPLKVLQSLMGHKSI
+SSTEVYTKVFALDVAARHRVQFAMPESDAVAMLKQLS*
+
+>NODE_5#PROKKA_00232
+MTADNASNIKVVHDPQTDEAPARPLGVDTPAGEAPGNDDRPAGPLEDALPGAEDDDSLLS
+CLLFLVAYHGQPKSPSVLLSALPKPDGPIPVDLFKRAAARAGLSVQVVRRGLGRIHAWTL
+PAVLLLRNRGAVVLTGKSDTGHFLVTAGDAGHGTTELSPEELERAYTGFAILVKPEVDLG
+GERTGADLAKPRSWFWGTLAKNGWTYAQVGMASVVINIFAVANPLFTMNVYDRVLPNNAV
+ESGIALAIGAATALLFDFILRNLRGWFIDFVGRRADVVLACRIFDQVLDLKASHRPQSSG
+AFASMLREFETVRDFFTSATLAAFIDLPFSLFFLAVILMLSPEIGMVLGSAMALVLFWGM
+FVQFPIAKSVKKLMVHGEHKHGVLVESLFGYETIKMVGAEGRMRAKWETVVGQSAAVGQR
+MRLFNNLGVNFVQFVQQGTIIAMVVTGIFLVKDGTVTSGGLVASVILCGRALGPMAQVSQ
+LMMRFHQTWTSLKSLDAVMRGPVERPPEANFLHRPRLRGQIEFQEVTFRYPGTDHDVLRD
+ISFVIEPGERVGIVGRVGSGKSTIAKLLAGLYAPTSGTVLLDDTDLRHIEPSDARANVGF
+VPQDVFLFKGSIKENIAISVPRATDDEITEVSQALGLHDFITQHPLGYDLEVGERGGGLS
+GGQRQAVALARTLLKTPTILVLDEPTNSMDTGTEKKVVDTLARTTGGRTIILVTHRTSVL
+SLVDRLIVMDAGRIVADGPKATILGGLAKGQVKTGK*
+
+>NODE_3#PROKKA_00189
+MAASAVRVSDTDRLTFTLFLALVLHAIVVLGVTFTAHKPQPSARTLDITLAQRDDQKAPK
+HADYLAQTNQKGSGTLSKKAQITTRHRAPINASQVHKVKPIPRSQPQHSQAKPEKRHVVT
+TVSQQATQQVDSDDKEQKAHQKHNHKSLMSRALEIASLEAKLDQETQRYAKRPRVLRVTA
+ASTLKSTDAWYVQAWVNKVTRIGNLNYPEAARRRGIHGTLRLLVDILPNGHVKDIQVLQS
+SGYKVLDQAAMRIVRLAAPFAPFPPELRKRKDVLEIIRDWSFEPRGLSTNG*
+
+>NODE_3#PROKKA_00172
+MENINRITTGNCSIDPIDNTEPQAYQLRVF*
+
+>NODE_3#PROKKA_00171
+MWLYGLFHHLPAWQLILIALAMTHVTIVSVTVYLHRHSAHNSVDLNPVVAHFFRLWLWLT
+TGMVTKEWTAIHRKHHATCETEEDPHSPVVKGFSEIMWRGAENYRAAISDEICERYGQRT
+PEDWVERNVYSRYRLGGVALMAVIDLLLFGVNGIWIWAVQMMWIPIFAAGVINGIGHFWG
+YRNFECADNARNIVPWGILIGGEELHNNHHTFPNSSKLSRRWWELDIGWGYIRLLQLFGL
+AKPKGYRPIAHQIPGKMDMDVETVQAIANNRFHVMRLYRKRVLEPVLRQQRSVVEKDIKP
+LYRRVRKLVFREESLIKPQERQSLEQVLQNSAVVRLIYEKSHELQAIWQRRPGMRPQDKL
+NALVEWCHQAEESGVRYLEEFAATLRSYSLRPQTA*
+
+>NODE_50#PROKKA_00228
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_9#PROKKA_00322
+MLIVMRQDASREQIDAVIRAIEARGYTARSIPGGDRVSIGILNNRTAIDAAWFQDMPGVK
+ETIPVTRPYKLVSREIQPHDTIIRVGGVEIGNGHLVIIGGPCAVESEAQVMATAERVKKA
+GADIFRGGAFKPRTSPYAFQGLGEEGLKILARAREQFGMPIVTEVMDLEYFDMVEAYADI
+VQIGTRNMQNFSLLRRAGESKKPILLKRGMSATIDEWLMAAEYVLSQGNPNIILCERGVR
+TFVRHSRNTLDLSAIPVVQRESHLPIIVDPSHATGFRDQVIPLSRAAAAARAHGLMIEVH
+NAPDTAQCDGSQSLYPDQFETLCRQVRSIFRILGETDETR*
+
+>NODE_3#PROKKA_00194
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_8#PROKKA_00294
+MNIYVGNLPYSVNDDELRGVFEEYGSVDSARVIMDRDSGRSKGFGFVEMGNDTEANAAIE
+ALNGQDFSGRPLTVNEARPRADRGPRRGGGGGGFDRRPRY*
+
+>NODE_6#PROKKA_00254
+MKKVVQAFMVLLALTITTGLMAQGTIKGTLKTTKGKTVPGVNILLKGTTTGTTSSLNGSF
+VLKVPAGKHVLLVSFTGFKPINYSFTIKDGETLTKNFVLHEDLLALDQVVVTGVQNKQTK
+LQSSVAITTLSPQKISQIAPRSAADLLKAIPGFYVESSGGKGNANVFARGLPSSGGLRYV
+QFQEDGMPVFEYGDLMFGNTDIMVRIDQTMSRMEAVRGGSASVLTSDAPGGIINIISKTG
+GPTTKGVFMQTIGLTYMHARTDFDIGGPVSKHLRYNIGGFYRADNGIRSPGFLANNGGQI
+KANFTYTFNKGYVRFRTKILNDKTIAYLPFPMMGNPAKSIPGFNANYGTMKSLDLLHLHA
+TTPTGNSVNESLADGMHPKIFAFGGEAFFDLGNKWSLKDNFEKTFTHIQFNSIFGVNAPE
+SASAYATAQGLTNYHYAFADGYNAGKPITNMSSLNGNGLVATYGWWSVGLNLQEFGNDFK
+LTKQSTNNTFTAGWYFSTNQVGGNWWWHNMLVDISGHNTRKLNLINDNTGESLTTNGYSQ
+YGTLYADYNALTVINAPYVYDEIDLGRLTINAGLRWDMGTITGRVENTGSYSYDVNGDGI
+ISPAEKNIQYGNGTYTPFHYDYSVLSYSLGLNYEFNKSTAIFARASQGHRSPADRAYVFG
+ATTSTPNGFPSSAKDESIEQYELGLKYNSSKVALFATGFYSFFNHIDFTDFVNVGGNLTA
+IQQYYNTSAMGLELEAAAQLGKLNLSLTGTAQSAKYHNWVYHDQSGNLHDFNNHFIQRLP
+KLYFTFRPSYNFGKLNVSAAWEYFGKRYTNPENKQVLPQFSQINAYIDYTVSPHITISAA
+GNNLFNVIGLTEGNPRSGLVSTGGSQYFYARSILGRSAILSFKYSF*
+
+>NODE_4#PROKKA_00215
+MTQNPDQKAPIWKRPATVEALNAHAKNTMVEHLAIEYLELGPDFLRARMPVDKRTHQPFG
+LLHGGASVALAETLGSVGANLCIADPDKAGVGLEINANHIRSARSGWVYGTARPFHIGGA
+TQVWEIRIQDEQDRLICISRITMAIVSAR*
+
+>NODE_8#PROKKA_00292
+MNIYVGNLPYSAGDDALRTAFEEYGSVDSARVIMDRDSGRSKGFGFVEMGNDDEAKAAIE
+GLNGQDLDGRALTVNEARPRSDRGPRRGGGGFDRGPRY*
+
+>NODE_17#PROKKA_00046
+MRARLFKWAGVFFLSLAMAGPAWAASRATPHRRPVLKLHFADVSYDYELKRAMSYAVSGG
+ADINECLTAARAITAGDGESWYRGWHRMARRLDQMADQALKAGHRQTARQFWLRASNYYR
+AAEFFLHGNPKDPRILSAWGASRRCFRQAARLMDHPVEVIAIPYEGHKLPGYLVKPDASL
+KPRKTLLLQTGFDGTGEELYMEVAWYAIQRGYNVLIFEGPGQGGALREQHLYFRPDWEKV
+VTPVVDYALTRPEVDPKRLALMGLSMGGYLTPRAAAFEHRLAALVADPGDFDMMVGHRPT
+PAEWAGMKKYPKQANQALRAKMKHDTGFRWLVNNGMFTTGRKTPLAFLEFFSRFELTPKI
+AAQIKCPTLVVVGAGDHFASPKWQRLLYDNLTAPKTLLRFGPDNPARQHCQVGGLLWGNA
+KIFDWLDQVLR*
+
+>NODE_4#PROKKA_00198
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_2#PROKKA_00122
+MPQFFKQLSTRELTERLNNKDVQLIDIRPVDAYNGWASRGESRGGHIRGAKSLPFAWTKY
+VDWIEMVHRKKILPENEIVIYGYPDEGFRLVANRFKKSGFEKVSIYLNFLNEWVPDTTLP
+MEKLFRFQNLVPASWVNELISGGKPQHFENDKYVIVHAHYRNRDAYLSGHIPGAIDMDTL
+AVEDPETWNRRSPEELKQTFEQHGITVDTTVIVYGKFMFPDNSDEFPGSAAGDIGAIRIA
+LIMMYAGVKDVRVLNGGFQSWLDAGYEVSYADEPKKPVADFGATIPAHPELAVDTPEAKE
+MLASSRAELVCVRSWPEYIGEVSGYNYIEPKGRIPGAIFADCGSDAYHMENYRNFDHTTR
+EYHEIEDIWKSNGITPDKHLAFYCGTGWRGSEAWFNAWLMGWPKVSVYDGGWFEWSADPA
+NPVETGIPENYPNRN*
+
+>NODE_10#PROKKA_00006
+MTLMVDVALAAPLWQPLTYAVPAELAPLVKPLSRLLVPLRGGARLGFALGEPLAAGGGQD
+ALKPVLDVLEDGKGPQVWPPELLPFFQRAAAYYHVPLGQVLAWCLPAGMGSARPAKALAP
+KTQQVAVVSWRRGEDSRLPRPESQAARILRRLKARGPLPLPELREEFPRAAALCRDLEKR
+GWVTISHRPLVKDLLGRPLLPEPEPEHYTPDQQRALDELLPAVHSGGFKSFLLHGVTGSG
+KTELYMACVKAALEAGRTALLLTPEIGLCLRLEGLLRQRFGAGQVAVLHSGLSPAARRGQ
+WLAIARGRARVVVGARSAVFAPLREPGVICVDEEQDEAYKQEDRFRYHARDLALLRGREQ
+DCPVVLGTATPAVTTYHRAQEGNTVCLRLPRRVREAPLPRMELVDLRREGRLVGGFLSRR
+LLAALEQTLEAGEQAILFLNRRGFAPAYLCTACGQTVGCPACAVSLTLHQGSDRLVCHVC
+GHQRPRPRTCPACGAGEEKLRPLGLGTEAVAQKLGELLPGARIARLDRDTAGDPRRLGEL
+LRAIAERRVEVVVGTQMITKGHDFPGIGLVGVLSADQALALPDFRAGERAYGLLTQVAGR
+AGRQGGKSRVIVQAYDPDHHALRAALAQRPDEFYQTELAERRALGYPPFMRLVALRLEAV
+DDRRCQRAAQALAAGLEEARRRLEPGARVLGPAPAALPRAKARHRWMILLKAPTAAAAGR
+TLRLGLHRSPPLPAGVRLLVDVDPVSLI*
+
+>NODE_1#PROKKA_00071
+MNGHWAREKRRMRVINRLLGLSAVVMVLVLVSPTASASIASDAVAYPPVSLSNVPPAKAE
+EIRKGEYLTKLSDCMACHTDHGNGKAGKPFSGGLAIKTPFGNIYSPNITPDKKTGIGNWT
+FKQFDDAVRYGEGPNGYLFAAMPYNYYSMMNKDQVHAIWEYLKHVPAVNRRNKPLGMPPP
+FRWRWLQFGWRFMFVKPTQGEFKYDPKHSKAWNRGRFIVEGPEHCGACHTPHNMLGGSEK
+RFFLGGSDITGFWAPNISGLATKPHPIATIMRVFREGKGLGGGDLKGPMIDAIANSMRYM
+TPADMRAVAVYIQSVQSEVPPGPRPVAMDEVNLARGEKTYQTDCAACHATGIGGAPRVGV
+AKDWDALGKSPLFILFENVWHGVSIMPPKGGCKACTRDDVTSAIVYMLKRSTSRSSKPAV
+QATTSKSGIPRDTVSLAVGDKIYHAHCAACHASGAAGAPRHGDIKEWASRLKLGLDKLHH
+NALDGIGMMPPKGGCTSCSKDQILSAVDYLVDGSGGKALVEKSLSGKQGG*
+
+>NODE_3#PROKKA_00186
+MTAQINVERLLETMCSQLEQTLEARGAVNPVLTGIRTGGVWLADYLHKRLRLEEPLGELD
+ISFYRDDFSRIGLNPRVKPSNLPFATEDRHIILVDDVIMSGRTIRAAMNELFDYGRPASI
+ILVTLLDLGARELPIQPDIVGQQMQLQRDQRVKLMGPDPLRVELRENVRENPAKDASTKS
+H*
+
+>NODE_2#PROKKA_00134
+MNDLKILYIQSRLAWEDAETNRKHFEEIIQKEAQHHDLIVLPETFTTGFPVDPVPFAETE
+DGESVLWMREMAAQTCAVVTGSMLLKNDGVYTNSLIWMRPDGTYERYNKRHVFRMGGEHE
+KIHPGDKILLVELKGWKIRPMVCYDLRFPVWTKNHYEKDAFEYDLALFVANWPAVRAYPW
+DQLLIARAIENEAYVLGVNRIGKDGLGNDYNGHSKVVDAKGNVISEAPENEEAAISVKLS
+YEALQKFRAKFNVGQDWDSFTIQK*
+
+>NODE_3#PROKKA_00159
+MQDLPVAVKDEEAAHPIAASCRPMLRKVVSAFVRGDYQLSQLIEGVSPVPPDVAAHIQDY
+IAGYGETLVELPEETWSTSCVQWMWSYWDVLVDLYTEREGASDLVLTRRMDEVEGKPQFT
+VGLVYVPKPQPNHAFQFVPWLTATPPDVLKRAAEFRGRL*
+
+>NODE_5#PROKKA_00237
+MIGNYGGLEHGLLFNLFRRRAFRRQYEEALEEARGLVATFSRNLADRLFDPVGALPMIER
+RRIEICRALIAHPKLLLLDEPSAGMTHDETHQLMDDILSVRDRLDGLAIIIIEHEMGVIE
+RVSDHCVVLNYGRKIAEGSYQDVASDRLVQEAYLGSA*
+
+>NODE_9#PROKKA_00314
+MRKQVEIMSSIDNFWLYMDHPTNLMIITGFLQFDKPINFERLKQTIKNRLLCYDRFKKRV
+IRPMTGVGNATWELDPRFDLRSHLHRVALPAPGDKETLQELISDLTATPLDPTKPLWQLH
+YIENCENGGSVLFARIHHCIGDGISLIRLLLSLTDTEPNAVWSDCLNEPKIEKETSFNLF
+PPLESAMKKVTRARRRAQKVTRFVSREIEKSFSNPYHIVKRTRTVTKFALDVATVMSKIL
+LLPADRKTVFKGELGVRKSVAWSDPLPLDDIKVIGKYFNATINDILVALVTGALRRYLQQ
+CNNLVGDLDIRVAMPINIRPIDGDIELGNQFSLILVALPVHIDDPVLRIREVQRRINDLK
+EAPDAAVAYAVLNALGVSSAKLAKTAATMFANKTTGVFSNVPGPRQQLYFCGEKINNIMF
+WVPRIGGLGIGISIISYNNEVSLGIATDSGLVQDPKAILDHFANEFRMLLGMYKAGQMEK
+EPLVINDRSVEPPVFAFNTEKIASVQAIRCKAITRSGTQCHNRAATNSMYCTLHLSKYET
+IASREENDMPAEADNTLPAEDQAAG*
+
+>NODE_7#PROKKA_00262
+VSEIQIVGVVGAGTMGNGIAHVFAKSGFQVRLCDVEQRFLDRGMDTIRKNLGREVTKGKL
+MQEEADAAVKRIEGTLARAALADCDLIVEAATEQLEVKRQIFEDLDRVAKPEVILASNTS
+SISITKLAAFTERPERVIGMHFFNPVPVMKLVEVIRGLATTQETFEMVKALAERLGKTAV
+EVNDAPGFVSNRVLMPLLNEAMYAVMEGVATPEAVDQVFQLGMAHPMGPLTLADFIGLDV
+CLDIMRVLQEGLGDPKYRPCPLLIRMVDAGWLGRKSGRGFFEYGNA*
+
+>NODE_8#PROKKA_00295
+MKPHRLAIFLGTFPMLFSLLLAGEGTMKEAGKSLRFGNGRLILTFDRDTGIWTGLEASGG
+AVCFRRTADSPSLNVQVDGKPVFGADRKMSLREQKVVQLPTASRLELTMGQGDWAVTAAY
+TLWDSGTLQRQATFVYSGPKPEGDHEVRNALFVLPDVGLAGTDAFWFATAEYPPRDHPFR
+HTDSGRRFGFPFSESTFHGFLARDPQAKLSLVSAYYTEDERAKLLVQEGKGTATAFHTHL
+LAETLRPGLRFEVGSQLLRVVPGTRQDALRALQGFYDLPGLRTKIGMPPDTGRQIFYSAH
+PGGTIDSSFRDVGGFANFTKLLPSIRDLGVNTLWLMPFWYGPVYAPYDYYRLDPKRCGTP
+AELKALTDKAHALGMRVLGDLIPHGPREEPGAKPSFAEQHGDLVCRDKDGKMIQWWGCHY
+CDYANPGWQDYMAKHAAYWVRECGLDGYRVDVAAGGAPNWRPYDHNRPSFSGLHGGLALL
+RKARAACLKENPNTIFLAESTGPTMYSAVEHGYHWAFSTLLEDHVLKDAPADFVQAMSGY
+LENQTYAFPADAFPIRFLTNHDKLRARYRYGPNLHRTLLALCAFMKGAPLLYEEEEMGNE
+DFIAKLYRIRQTYDELSVGTVSYRSIPVEPKHVFCIEREYKGKRSVVLINFSNQMSEVKL
+SLPKSDLKNPGIYEAVSGQRVDYAQDLTQSLDPYAYAVLVIRQRDELPPSVPKERGESPA
+APDGRAMDIKITQEDSLTRVSTPLYSAVIDSARGGLLQEVRGADGKLLVNGVELKEGRRK
+LFVGHDSVDFADCSVPLRILARDRQFPDGGKVSLLRGRAELRDGDGHAWMDLTVLYSLRA
+KSLSLNVSLTPQYRLSPSKSDLGMKIHFVPTTHWFAETAEGNLLGHVIRRHPASHGFSGR
+YWHGAGEAFFNGSLYPVVGEFGVLDTNRRIALGSMALRLDGAPLPVRLLEDEPPGSPVVL
+GGPAAATADIPLLRGSQRAVWQQGKAKGMVVTLDFRSVPARFTQYPDSFGVRGWDTGTPK
+LCYRGGWCTFGPEYLFRGYGMRATVVRSHGGELTALTDAAGNGLRVTDARFYTDQGLFGD
+WRDPRGVLRKMSASNVNDPEPDTQLLHLFEGPQDSAPLRFRSFFRHPHAGGRSLLNPRVE
+YEISYTPPTEKGKGLRIDCGVRPHLVKIGTGGFLAYKISLGGCDQWQVDGGEWQPLPAKG
+GRLWENKEAGHLPKTLLLRNSKTGLWTRFSDFVGGPDQVENVFLHAGQGQVHLFVAFYDA
+EPTDVRPVWRRAAFTMQAGGKQ*
+
+>NODE_2#PROKKA_00110
+MCNLLIKFGAFNDRFGKDFDRISTGHYATRYNTDEGVFLSTAADRVKDQTYFLGQITPEQ
+LAKTMFPIGHLQKKEVRKIASDMKLPSAHRPDSQGICFLGKINYTDFIKKYAGEKPGEII
+ELETGKVLGTHKGFWFHTIGQRRGLRLGGGPWFVVKKDIEKNIVYVSNGYDPIAQYDDKI
+WLEDLHFLNKVHDYSKLNEIKFKIRHQPEFNSGKLVRDEKGIRIVSENKISGIAPGQFAV
+VYDEEERTCIASSVIAENPEIAV*
+
+>NODE_6#PROKKA_00255
+VKHIDISPIDIAIIVIYIVGIAVWGLMYSKKKSKGKGHEGYFLAGRNMTWPIVGITLYAA
+NMGSPALVGLAGDAYSTGISVFNYEWMALVVLVFFAIFFLPFYLRSRVYTMPEFLQRRFD
+IRSRYYFSFITLVGNIIIDTAGVLFSGALIVKMIFPAMALWHIIAVLAIITAAYTITGGL
+SAVMYTEAVQGVLLMLGAVLLTFFALKRIDFNVARIFTETPHHMMSLIRPNSDKAMPWLG
+LVLGVPLLGFYFWGTNQFMVQRVLSAKNTNHGRWGALFAGILKLPGLFIVVLPGIIGRLI
+FPHLSDPDLIYPMMLFHLLPVGILGIVLAGLIAAISSSISATLNSASTLMTMDFVNNLKP
+GLTPKQLVRIGQIFTGVFVVISAAWAPMIAGFPSLFKYLQQVLALISPPVVAVFLLGLFW
+KRANAQGAFYGLMGGLLMTIFAVIVRYVNPDIFPWLGHIQFLLVAPVLLVGTMAIIVPVS
+LMTPPPPEEAVAQFTWSFKFFNAESMELAGTPWYKNYRYQAIGALLATAILVYIFR*
+
+>NODE_2#PROKKA_00108
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_2#PROKKA_00114
+MKTFLDLVNQRQSDRKYIDKPVEKEKLMRCLEAARLAPSASNSQPWTFVVVNQPELCQDV
+GKAAMGPLYSFNKFASQAPVILAIIMEKPKVITEVGGRIKKKEYPLIDVGITAEHFCLQA
+AEEGLGSCMLGWFDEKKVKELLHVPEEKSIPLLITVGYTPENYKHRKKIRKPIDSAVKFN
+TYG*
+
+>NODE_3#PROKKA_00191
+MEDNFENLKIMVIDDSKTIRRTAETLLKKVGCEVITATDGFDALAKIADSHPDIIFVDIM
+MPRLDGYQTCALIKNNSAFKSTPVIMLSSKDGLFDKAKGRIVGSDQYLTKPFSKDELLNT
+IRQHIPSREST*
+
+>NODE_7#PROKKA_00273
+MPNQCRHVRANGVQCRAHRVWKEDYCFFHLHHRTPNGTAKRSEDPPPPPPKNGIEIPLLE
+DLASIQIAIGRVLTALAQGKITSAEARTYLYGLRLAASNVKQKDFAPVNTVETYVQYDNG
+DTLGPEQFHAEKQPQHPLMDSGLLALRHLSNRLTYEATLDAYLTQGQEPPSTLRPPVAGP
+PADKSELQNWIKTGWKACQSRAHALELARKAIDQPIPDPIDPKAAFSINANIQRTA*
+
+>NODE_21#PROKKA_00094
+VEPTVPSPLLDRRQRGDAFLRRYWKLAAPLLILFMLALFVLPWVWFSFVEALCLQVGGAG
+LLYILGRLFTTAFNPAYHQAPEPQDGDAGRRDPSSSDPPPRA*
+
+>NODE_7#PROKKA_00265
+MSATRGIQHGVDMRVEVADIQLPNPVLAASGTFAYGIEFEDVVNLDHIGGFVTKGISREP
+LSGNPAPRLIETAAGMINAIGLQNIGADAFVQQKLPALARYQCPVIVNIFGYQMQDYIAV
+IRRLNEAEGIAAYELNVSCPNTHAGGIAFGIDRAALSDLVAHARHYSRRPLIVKLSPNVT
+SIATMARSAESSGADAISLVNTFVSLAIDVETRRPRLSNITGGLSGPAIKPIALRMVWEA
+AQAVKIPVIGMGGITTPEDAVEFLLAGASAVQIGTASYADPRAVEHIGQGLAHWCSRHHI
+AKVSELIGGMQTGQ*
+
+>NODE_4#PROKKA_00201
+MASRIHWDWRAGLVLLALIVLAFLPFGVSGYILGVMTVAFYLAVYAMSWDLLFGYAGEVN
+FGPTFLVGLGAYGAGLSNSVFNISVWPSVAIGTLAAVIGGLVLAGPALRLRGPYFGLVTL
+VAVILLEKVIGLLSSYTGGEIGLTVMDVLTISQSGNYYYAFGFMVISAVILRIIARSSIG
+LILEASGQDPVATEALGFNVTKFKFMAFTLSAFFSGLAGALTVFYLGSASPGTVVSVFVT
+IQIIIATLVGGRRSIIGPILGAVFLIAAGEILRPLGQLSNAVVALIALLVVLFAPNGFIG
+LFSRTGGAR*
+
+>NODE_2#PROKKA_00138
+MQQMEILERYLNENKTINEFKKVLWIYDFWGKLTEGKAAKKVLEFAGIKNGISVLDVACG
+TGEMLEKVVKLNPDGQNSGIDLSPDMIAKARKKLSKTGHLNFNLKQGSALDLPFPDNSQD
+LLINSYMVDLLPVDCFDKVATEFFRVLKPGGKVVMSTFSFGTKKVHRFWFWVARKFPALL
+TGCRPVSFKHFLIKAGFEIVKDVEISQNTFPSQVLMALKKS*
+
+>NODE_5#PROKKA_00233
+VKSFSDAGVAANRRNGHRNATPSGRLGHSLSWGSLLLSGLVVFGGPFMADAQAQQLREAV
+EMAVQSHPMVASTEAEYRAAERSVDQVEAGFYPSLDLTADSGYQHARRVNESSIKENQWR
+NKQRLAMTQMLYDGEGTANRAESAKASAQSAHFDVLSAATKIAQRAIRAYLDVARDRKLV
+QYAVDNIDLHRRILADVEEAARSGGGSETRVTQVKTRLYNAQSQRRRAEGNLRNSISDFQ
+EAIGETPETLEDYPMPTVAIPASVDEARDEALKNNPSFQAAVETERARTLTANAERSGYF
+PQVDVEVAHEQRDGVDGVSGFETDSTALLTLSWNLYGGGADQAKVRRALEQSSAAMYRIH
+EVERKIRRELEVALTDYEVARDQVALLRERAATAKEVTAAYREQFRLGQRTLIELLDSGN
+ELFLARSDLTTAEYRQISAAYDFLAVRGTLLKDMGVKVATGKAPKAP*
+
+>NODE_12#PROKKA_00026
+VSRDWFPAKVRFMSGGRAQQTPLAIRVEGRWLEVRLLGEELVAPESGLAYVRRYRLEDRR
+GRRWELRQRQEGWFCRELH*
+
+>NODE_4#PROKKA_00209
+VVDDNSDLGLDAALDPQNGAKDRKFVTALARGLEVLRAFRPGDGFLGNQEIARRTGLPKP
+TVTRLTYTLTKLGYLSYSQRLERYSLGTGALALGYATLSTFGIRQIARPLMQELADDVDA
+SVSLGARERLSMIYLENCRGSGAVTLRLDVGSRIPIATTAVGRAFLAALPEGERNYLMDH
+IKRHAGNRWPPVRRGIERAIRQYQETGFVKTVGTWERDVNAVGVPLVQSDNGNIYAFNCG
+GPSFVLPEERLDAELGPKLKQLVQNVEAALRRL*
+
+>NODE_1#PROKKA_00063
+VSWEAILTLVVLGAVVLGLAWPRMPPDLPLVGGLAILAVTGCAPIDKVFSGFSNPGLIAI
+AALYIVAAGLRHTGAVTAPARWLFGRSRRLWVAQLRIMLPTAVVSAFINNTPVVAALLPA
+VLDWGKRHRFAASRLAMPLSFAAILGGTCTLIGTSTTIIVNGLLTSTTHGPGMGFFTIGA
+VGLPVAIAGFIYILLFGRRLLPDRQGAMGEFTNPREYTVEMRVAAGSPLAGQTLEAAGLR
+HLPGLYLVEIERGGNLIPAPGPEELLEENDQLVFAGIVESVADLQKMRGLIPTTGQIFKL
+DTPRPDRRLIEAVIAPENPMVGRTVREGRFRSRYGAVVIAVARAGHRVTGKIGAITLIAG
+DTLLIEAPSEFQRRYRHSREFLLLRPLEESVQPHYERAWIAWLILAAVIGLVTARIVPLA
+PAAIFAAVAMVVTRCINLAAARRAIELQVILVIGAAFGIAAALVHTGAAALIAQPLLALA
+EGSPLGMLVVVYALTTILTAFIGNNAAAVLVFPLAYAAATKLGQPFLPYAIAIAMAASAS
+FTTPIAYQTNLMVYGPGGYRFSDFVRFGLPLNLIVGVISVVVIAWLWMP*
+
+>NODE_13#PROKKA_00043
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_5#PROKKA_00229
+VASLDLDVRQASLTRYLENRAAFAARRGVSLPMPSHRRGNDPTAPDDVAEMIRAQAAGHD
+VLLVDTPGRVDAVSMAAHVVADTIVTPVGESHLDLDLIGNVDRNQGRAIRPGPYAEFVWA
+VRQERARAGRTPTDWVVCHNRRRAPQTRVGREVERTLADLSKRFAFRLVPGFSERTIFQE
+LFPDGLTLLDLRESETGVGLTLSHVAARNEIRHLVDALDFR*
+
+>NODE_9#PROKKA_00307
+MIRVGVAGATGYAGAELVRILAGHREVRITALTSRQYAGVPFAKVFPALAGVVSNECEAF
+DVERVCGQTDVIFTALPHKLPMAIVPGLIKNGKKVIDLSADFRFSDVRLYESAYQPHSSS
+DLLSRAVYGLSEVYTDDIRKADLIGNPGCYPTSTLLPLVPLLKNRLVDSGGIIVDSKSGV
+SGAGRSPSLTVHFSEVNESFKAYKVAAHRHEPEIESILTKSAGTPVDITFVPHLVPMTRG
+MATTIYAGLAGNVTKHDIAACLCDYYAGRQFIRIDRDGHPPDTRNVRGTNYCDIAFVVDE
+NNRRLILMSVIDNLVKGAAGQAVQNMNLMMGFEETAGLSAPPFPV*
+
+>NODE_11#PROKKA_00024
+VSRPRYVRTQRHGPVTVVVMDNPATMNAMDQDMGPRLVGALESLAADRSVRAVVLTGAGG
+RFSAGGNLTRAEEFLEENPGRGAAPVFAQYTIWVHRLLAVLTRLPQPVVAAVERAASGGG
+LGWLLACDLVVLAEDARLSTGFLAIGLAPAAGVSWHLPRLVGLPRAAELLMLGRTLGADR
+ALELGLADQLTPPGGTLEAALELAGELARGPAQALAATKQLLGGAARRGLFPQAEAERRA
+VLHTADQEEFARRLERFRQRRRRS*
+
+>NODE_8#PROKKA_00299
+VKPASVLLATPDGEGFYRFSDPVRVVTAGSLEEVLPTVTAVEAAVAQEGVFATGFVSYEA
+GPAFDRALAAYPPGEFPLVWFGLYRNREVVPKTEMQDVPPLAWRPCLDQDEYVAAIRRVR
+EYIEAGDTYQVNYTFRLHAPFAGDPEALFARLASAQACRYAAYVDTGRYVVCSASPEMFY
+TQNADVFRSRPMKGTRPRGMTLAEDRAHREELLESEKDRAENVMIVDMVRNDLGHIAEAG
+TVHVPELFSAEPYPTVWQMTSLVEARSRAGFGQTLKALFPPASITGAPKPRTTEIIRELE
+TTPRHIYTGTIGYLGPEDARFNVAIRTVLIDRQTQQAEYGVGGGIVWDSDPLAEWEECMT
+KTRVLRTVRPEFSLLESLLWTPDEGYALLDRHLARLCDTAEYFGYPVDVVSVRQKLEELA
+GNLEPVPNKTRLLVDRHGEITVEGSPLGPAPDALVWRVCVHPERVDSHDPFLYHKTTHRA
+VYTQAAAAHPDCDDVILQNERGEITESCRANVVVEMPEGRFTPPVSCGLLAGTQRAELLA
+RGEITEKVLTPEDLYAATKVFLINSVHGWVVAELSDSSD*
+
+>NODE_11#PROKKA_00018
+MDHAALPQTLAPGLYRLGSYHLACFLVETPDAALLFETGMSLVAPLILAQLDELGVPREK
+IRWIVHSHAHSDHSTGQAALLEALPRAELLLSPTSRRHLAKPSTAEQFAKEDDSTRRALE
+RIGALPPGSLPDPLPLLPARHRTVEPGDTLDLGGLTVELRSAAGHVPGGLLAWLPELGAF
+LASDSAGFHMAARPNYPLYFTGYREYLRTLEEIRRTNPELLCLGHQGWFRGGEARRYLEA
+LKAHLAFEHATIWEAHRRGEDEESQARRLVERYYHDELAIYPRDILWYCCRLLVRRSLEA
+GA*
+
+>NODE_1#PROKKA_00086
+MILYSRPDDPAAHSIRLVLAEKAIGVKIVEVEPDSPPEDLLHLNPYGTLPTLVSREVVLY
+DPRIIAEFIDERYPHPSLLPSDPVLRARARLFVSEIGGSWYELCDEVANGAGRGRTRARR
+ELTEAVVSSDELFTGTAYLLGGDYGLADCVAAPVLWRLPHLGVRLPREAKAIRGYMQRVF
+KRPTFVYALVASERAMIES*
+
+>NODE_9#PROKKA_00306
+MKISQLSIFLENRSGRLARIATVLGNAGINIRAMSLADTSDFGILRLIVSDTEQAEKTLK
+DQGFTVLISAVVAVAIPDSPGALGNVLSIMEHAGLNVEYMYAFVEKDMGQAIVIFRFDDV
+DRAISTLIENDIAVLESKRVLRL*
+
+>NODE_1#PROKKA_00076
+MNLILLGGLSGAGKTGALDMLEDLGYQIVDNLPLSLIEPAIDAMLGDDARHHSRLAIGIA
+PHNTPEEFEALARQIEIWRTRPHGCTVIYLFCEPGTLVKRYRATRRRHPLTGPDTDLAAA
+IEIETTLLEPLAQLADACIDTTHTNIHQLREIIRARVNEGGDHPMALQIESFGYRRGLAQ
+DADLVFDMRCLPNPYWEPTLRELTGLDQPIAEYLETHGTVTRMLSNLVNFLNAWLPSYAA
+SNRSYLTIAIGCTGGRHRSVYMAEQLAAQLAHGGWAVTVRHRDLDTPTRDVKPILADD*
+
+>NODE_1#PROKKA_00048
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_2#PROKKA_00143
+MKSEVNGRVEDILFKEGGSVKKGQPLYTINKSLYQAAYDQAAAQLNIAETNWATDTTDAR
+RYKNLWAHNAVDKIQLDHAIAKVNVAKASVIAAKANLESAKTNLDHATVRAPFSGSTDVS
+KVRLGDVVVAYQTPLVTIVDNSNMNADFFITENDYLQLGSSDKSIKEKLSHFRLVLPNGK
+LYPYKGKLYAVDNRVDPTTGTLMVRLKFPNPEDLLKSGMNCVVRSTQNSAGKVVVIPQQA
+VTQLLNEFFVYTVNSKGIVSQQKVELGAEYGNMQVIKSGLKPGTKVIVEGIESVRPGAKV
+KTVPMKTGGMAKQSKPE*
+
+>NODE_6#PROKKA_00244
+VGQKLVSIVMGSDSDLPVMKPAAEMLEQLGVEYEIDIVSAHRTPEKLFDFASNAHKRGIQ
+VIIAGAGGAAHLPGMVASMSPLPVIGVPVKSSNSIDGWDSVLSILQMPGGVPVATVALNG
+AKNAGILAAQIISVSDSQVREKIIEYKAGLKEAVMKKAKNLKG*
+
+>NODE_10#PROKKA_00003
+MKKFKRLCLALGVAALGLAILAGPALAKKDVLVVIQEAEPVGLDLMTSSIQTTMSVCYNI
+HDTLFAPQEDASVKPRLAESWEKVDDLTWKIHLRRDATFHNGEPVNAQAVKFSFERSFKP
+SIKNPHKGKLSAFKEVKVLDDYTLLISTKEPYAPGLYILGYYLPIVPPGYIKKVGDAKYN
+TNPIGCGPYKLEKWVRGEEIVLTAYDKYYGPKPAFKKVIFKGVPEEASRIAALLTGEADV
+ISGVSIHQRKRILASGKAYLTNQMGVMPYLGLNTYKPPFNDVRVRQAMNYAVNRELINKA
+LFGGKAILCAGPISPRTFGHDPNLKPYPYDPAKAKKLLAEAGYPNGFQTRLAYPTYMSQI
+QEQAEAIAADLAKVGVKVRLEPYERAVMWQRYKARKHAMYIYWWDDAPEPDRYMYSLFNS
+KVRDYYYKNPEVDKLLDLGRTILDRKKRAEVYHKIDRLLYNDAPWVYLYVIPEVFAVSNQ
+VAYQGRRDGFLDMRTAKPK*
+
+>NODE_1#PROKKA_00069
+MGVKSLKDCELQNRRVLMRVDFNVPVNDGAIADDTRIRAALPSIHEALKAGARLMLMSHF
+GRPEEGKPESRFSLHPVARRLGELLGFDVPLVTDYLARDPEPGSGRAVLLENVRFNVGEK
+RNEETLARRYANLCDVFVMDAFGSAHRAQASTYGVARFAPQAVAGELLCAELKALGRALK
+APDRPLIAIVGGSKVSDKIGVLDALIERCDGLVVGGGIANTFLAAAGHPVGRSLYEPGFV
+DEAKRLMIAARERGVNFPLPVDAVVAEALAEDAEADVKPVHAVGAGDMVLDIGPETAVLY
+RPLLANAATIVWNGPVGVFEIDQFAEGTRAVAEAVASSGAFSIIGGGDTIAALAKFGVTD
+RVSYISTGGGAFLEFLEGKTLPAVDILEARASD*
+
+>NODE_6#PROKKA_00248
+MMIDAAKRASARKIVAVIPYFGYARQDRKDKPRVSIGAKMIANLLTTTGIDRLITMDLHA
+DQIQGFMDFPVDNLYASVIFYPYLKKLNLPNLMMASPDTGGTRRAANYAKALDTGFVICY
+KQRTRPNVVEQIQLIGDVAGKDVVLVDDIIDTAGTITKAARVILDKGANSVRAMVTHPIL
+SGDAFKIIADSPFTEVVVTDTIPVKDDLGGKIKVLSTAQLFSEVIKRVENYKSISSLFNL
+GNQSNK*
+
+>NODE_3#PROKKA_00154
+MKDIQLESTIICPACGHQKTEQMPTDACQYFYECESCHTLLKPRAGDCCVFCSFGTNPCP
+PVQQGDDCCASD*
+
+>NODE_2#PROKKA_00119
+MSGKLQAEFRSDLKWQPAILRKILILPSKQVLIILSLMAVVVVQARPPLF*
+
+>NODE_9#PROKKA_00303
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_9#PROKKA_00302
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_9#PROKKA_00315
+MNAPAPTPNNPRIVVCCGSGGVGKTTISAAIGLCGALMGKKTVVLTIDPARRLADALGIS
+ALNMEAQRVPLEASVPASGELYAMMVDAKRTFDRLIGRYSSAGLRDRILENRYYQHVSNN
+MAGSHEYMAMERLYEIYHEKRFDLIVLDTPPSRRALDFLEAPQRVINLLGHPYFLKLFKP
+YIKAGQLSGRLFNLLAMPVLRAVGQVVGGQTISDIFSFFQLFNDMLFDGFSKRASAVESL
+LSDPMTTFFAVTTPQEYPIQEATYLFRQLQQRNMPFGGFIVNRVHSDTADSPFDSEAADR
+KRVLMEKIADKPIFQRLEIADRMDRKLARSDAAAIDRISSISPGLAVFPILFADETVNDI
+SGLRVISTQLMKHPEFKI*
+
+>NODE_7#PROKKA_00258
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_1#PROKKA_00054
+MARYIGPKCKLARREGTDLFLKSPIKALDQKCKIDRIPGQHGQATRRGRMSDYGLQLREK
+QKLRRMYGVLERQFRRYYKEAARRKGATGALLLQLLESRLDNVIYRMGFASTRAEARQLV
+SHKGVTVNGQLVNIPSFEVKGGDEVALTERARKQNRVEMALEISRQIERPAWVEVDEKAC
+KGTFKAMPEREELLPDINENLVVELYSK*
+
+>NODE_21#PROKKA_00093
+VLFTQIIAFVLVMVVYQAYDPAPPDYGWGWGLLLFITGPLLEWLLASVIARSGLRRLARP
+AADPARSLQRSEILLHLSALTVFFLFMVSYDLKAGLIATPLLAASETLSGLAALFYYALL
+LIPVWGHCHRLERAAGRALALDRRRYILEQARFVAPVAFPWFLVSALRDLLTLAWPGLTA
+WLETPAGDLAFLGFFLLVISWLFPPLVRSWWGCPPLPPGRAREICQMVLKVARVRVGGIL
+SWDVLQGRLVTAGILGLFPRFRYLLLTPALLEALSPTELAGVVAHEAGHVRLKHIPAYLM
+FFMAFFLLAYALAEPLDILLRLALLTLAQSDWGAGLLNSPDAGSTLSITFALPLLALMIV
+YLRFVMGFFMRHFERQADLFALNLMGEAAPLVGALEKLALMSGQTRDLPSWHHFSVAQRV
+SHLLTAQANPPAWLHRQGRLIKKALAVYLAGMVLVLGLGWGMAGLDWSRQVNQELALELV
+RHQLAQHPDDPRLRFQAGMLCYQLGREDRALSHFRRAFLAAPDNPELLNAMAWIFATSQD
+PRRRRPQVALVLARRAVSLSPLPHIWDTLAEAYFAAGQPVKALAAARAALEAGPKARLDY
+YRAQLERFKRAVEDLKKKGPAGRRPRPAAPAPGGRQG*
+
+>NODE_50#PROKKA_00227
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_4#PROKKA_00224
+MKGKFSLKSTRTGSMMAKGALAAALLTAGMGVANASTTLQETGSSLLYPLFNQWIPAYSK
+AHSDIQVNAASTGSGTGIAQSIAGNVQMGGSDAYLSGAMMKKHSDMLNIPVAISSQMVNY
+NVPGLNDKHLKLSGPVLSRIYEGTVKYWDNKEIKAMNPGVDLPHHRIVPVHRSDGSGDTF
+LFTQYLSFSHPYWHKKLGYGTTVNWPAVQGEIGATGNPGMVQALKDNPYSVAYIGVSYKG
+QIDKDNLGEAMLKNKAGNFVLPNSTTVPAAAAAMVPKTPKDERISLIFAPGAKSYPIINY
+EYVIMHANQGDLAAPLKQFLNWAVSPNGGNASQYLGAVNFMPLPKKAEELTKAQIAKIHS
+*
+
+>NODE_4#PROKKA_00213
+MGRSDVIAGLSLERLDNIERHIDRKYLKPKRLPGTLTLVARRGQVAYVKAQGLMDVERNK
+PVARDTIFRIYSMTKPVTSIAMMQLFEQGRFLLNDPVHKYIPAWKNLRVYQSGVYPQFLT
+TPTLRAMTIRDLFTHMSGLTYGFMCRTNLDAAYRELKLDGGKEMTLDLLVERLSQLPLEF
+SPGSAWNYSVATDVLGYLVQLLSDRPLDEYFREHIFDPLEMADTGFMVPESKRERFAACY
+QFDPEQGYALQDDPADSHFTRPIKFLSGGGGLVSTVDDYYRFAQALNNGGQLNGARIIGR
+KTLDFMTMNHLPGNQDLPGLSIGPFSETPYEGSGFGLGFSVKVDVAKSQTNGSVGEYGWG
+GLASTNFLVDPVEDLIMVFMTQLIPSSTYPIRQELRSIINGAIVD*
+
+>NODE_5#PROKKA_00236
+MTAVSSAVSDSAAVPQTADVAVEIEGLFTGYDKADVLLDVSLTVPKGQITCLLGSNGAGK
+TTLIRSILGLTPPRQGTIRLFGEDTTGLPTHKVVARGVACIPEGRRMFSKLTVEENLRLG
+AYQEPSEAKIRTSLEDVYQTFPRLAERRNQLSGTLSGGEQAMVSIGRGLMGAPRLLMIDE
+PSLGLSPLYVQENFRIIENIRTRGITVFLVEQNVHQTLAISDYGYVVSGGRLVAQGAAAS
+LQNDPEVHAAYFG*
+
+>NODE_11#PROKKA_00021
+MSRRQQENGAVWVFGDYRNYFQNRVTLQLLARARDLASHLDTKVAVVVMGYRVGRWVREY
+VAHGADVVYVLDHPSLKYYLVQTYTRLMERLAGEHQPQIILVGATGFGKELAARLASRLG
+TGLTADCVDLTVDDQGRFIQTAPSFGGNLLAQIMIPQARPQMATVRPGTFQELPHDADRR
+GEIIKLPLPDDLPPEKARLIHSRRIKPRRRKLEKARVVICGGRGMGSKKKFKNLYALARL
+LGAQVGATRPVVYQGWAPEDALVGQAGRDVHPEVLFSFGVSGAIQHTAGIHDAQFIVAVN
+KNPAAQMMKMADVAIAADANQVCLALIRELKARLEKKK*
+
+>NODE_9#PROKKA_00311
+MRKKIHLFLVIGCIVFCFSPAVFAKTGGPKVLHYPREDAVVRAVKLVSPAVVNISTQYEV
+RTRVNPFANFGANDFFNNFFDQGIERKEKLTSLGSGVIIDGRRGFILTNAHVVVRGAKIT
+VVLKDGRKFHADIVGIDPESDLAVLKIKTKSPLPSIAMGNSSDLMIGETVIAIGNPFGFS
+NTVTVGVVSAVDRSFRIKNRIYRDLIQTDASINPGNSGGPLLNIDGQLIGINTAIYKNAE
+GIGFAIPINRAKKIISDLIKYGEVVPGWIGLSVQNLNSRLAAYLNLPQHSGVVVRSVDPS
+SPAGAAGIREGDILLAIDGHKIESIDDYKTAMRGYRKGQHAVVKIDRNGRHLTLSVRIEV
+FPESLAPELVQRLLGVKVVGIGQKVRFNQTINADKGVIISEIDPQSSLAGIGVRPGDVIR
+KVDAEATNTVQSFYKAMIKDRWKQSIVILLQRGDQGYYITLKLS*
+
+>NODE_10#PROKKA_00001
+MMARPGRVTSHQASVMYARPSANMRPQVGWGGGTPMPRKESPLSQMMILATRTVPSTKSG
+ERMLGRMWRRMMVRFRVPRLWAALTNSFSFRASTLPRTVRA*
+
+>NODE_1#PROKKA_00074
+MKKIVIANLKGGSGKTTVSTTLAAFWASEGYKTCLLDLDPQRAATSWLRRRPESLPSIHT
+LSLPNQTSGVTLSYALRIPRDTERLVVDTPAGLSGIALADTVRGAAAVLIPVLPGTMDSD
+AAARTVADLLLIAKLGRHSGRMAVIANRVRRGTLGAERLQKFISALDIPLIATLHDLQAY
+SHAILSGLGLHELPRRRIGGERMAWVPLLEWLERRELEITAQTALGPRSLLTQSAGQTPS
+DSME*
+
+>NODE_9#PROKKA_00323
+MILIDILRRNWYDLLPLNEIGNICAVKFGNKAADP*
+
+>NODE_2#PROKKA_00150
+MYKKLLLLSLTFFMFTSFTNIASAQSNNIEIARLKQIHKLLDYRFVGGFYGFEKLFFQTV
+SYPDEARQNCTLGIMIASFTVNCDGDLVGIRIRNSLGKPLDNQVSKFLKATKGHWNPCQD
+KKFTHFEIPIQFTLKGTETDSTAAALVYVGKSAGYSCYPDSYYSVPRLFPGGIL*
+
+>NODE_3#PROKKA_00167
+MIRFEHVTKRYEGGHVALRDVSFALERGEMAFLTGHSGAGKSTLLKLIMLMERASEGQVV
+IGGQVLDKLPRRRIPYIRRHIGVVFQNHQLLFDRTVYDNVALPLEVMGIAPREVGRRVRA
+ALDKVGLLSKERMNPMELSGGEQQRVGIARAVVNKPPLLLADEPTGNLDPELSASIMHLF
+EAFNQVGVTVLVASHDISLIRHLGHRVITLDGGRLAQGDRMPDEEALYG*
+
+>NODE_5#PROKKA_00231
+MASPDIEYMSELRAAVSRRPTILANIILIAVLVFFILAILWASWAKIDQVSTGEGRVIPS
+GHVQVVQNLEGGILSELYVAEGDHVKQGQVLMQLDDTQFSSDFMENRLKFLGLKAAVTRL
+QAELEGTALKFPAEVEKQLPAVAQAERSLFEARRSEEDASLAKLQAQYQQKLHEVDETKA
+KIEHLRTVIKLAKEEMAILEPLVKKGINAPIELIRLKREESQDAGDLAVARQQLLKLAAA
+IDETKEAITEAKAQFRSRALKELNEAQVNMAALGQVVTSRDDRLRRTVIRAPVTGVVKQI
+FLTTIGGVVRPGMDLMEIVPAEENLLVEAKIRPSDIAFMHPGLEATVRFTAYDYTIYGSL
+KATLDQISADTIFDEAKKERFYMIRLRTKTNSLLDKTGKPLPIIPGMTVSVDVKTGRRTV
+LQYLMKPFHKLSIRAFHER*
+
+>NODE_13#PROKKA_00036
+MFKVMIRDSMSPVAREILTATGKIEVVTDNDKAANAPEVLAEMIGEFDGLAIRSGTQVTR
+AVMEKAGRLKIIGRAGIGVDNIDLEAATRQGIVVMNAPGGNTVTTAEHTVSMMMALARNI
+PQATASLREGAWDKKKLIGVEIAGKTLGIIGLGHVGRIVADRARGLKMRVIAADPYVSCD
+AAARINVRLVSLDELFSASDFISLHVPRLKETVNMINADTLSRMKPGVRIINCSRGDVVN
+VDDLYRALESGRVAGAAIDVFPKEPPDASLPLLKHPRVVLSPHIGASTGEAQVKVARMIA
+EQMAACLIDGVITNAVNFPSVSMEEMARVV*
+
+>NODE_4#PROKKA_00216
+MKQMQNRVAVITGAASGFGLEFARVGAARGMKLVLADVQAEPLEQARAEMEAAGAEVLAM
+LCDVRKSEQVQALADKTMERFGTVHLVFNNAGVGSGGLVWENTEQDWEWVLGVNLWGVIH
+GVRIFTPLMLEAARRETDYEGHIVNTASMAGLLCPPTMAVYNVSKHAVVALSETLYQDLK
+LVNAPISASVLCPYFVPTGISDSHRNRPAELQNDSGPTASQMIAQAMSQKAVSSGKVSAA
+EVAQRTFEAIGEDRFYIYSHPEALGNVKHRMEDIVAGRNPGDPFAEAPQIGQMLRDKLQG
+*
+
+>NODE_10#PROKKA_00005
+VARAVDGVDLTVGRGEILGLVGESGCGKSALALSVLRLLPMPPAFFAGGQIRFKGRDLLK
+MDPEELRRLRGNQISMIFQEPMTALNPVFTIGNQLGEVFRVHQGLARREARRRAVEMLEM
+VGVPAPARRVREYPYQLSGGMRQRVMIAMALACRPALLLADEPTTALDVTIQAQILELIL
+ELRDELGTAVVLITHDLGVVAETTERLAVMYTGRIVEQAPTVELFDHPLHPYTRGLLEAI
+PSAEAELADKELHEIRGVVPSLLDLPPGCNFAPRCHLADERCARQEPELVEVRPGHRVAC
+WRVDRG*
+
+>NODE_11#PROKKA_00015
+VQFVQSSYPLAGLWRPGQETPPASGDTSGSGGVSGGAGFARMLDGKLRQGEPADLSTGAT
+RQTGGPVRYSPHSPLLVGASIGAAPGLFTAPVVWSDPTPAAPKGAYRMHSANPRSTFPLR
+TVPPPPAPPPSSEHENEDVGLPSAISTYHGSRFRAEVQVGERQEVNADVEQFHFPHLVQK
+NGLTYAYFIDHSHGSENDVGLAVSKDGVNFQYQGKVLTKGPEGFDAQMASFPAVQYDGET
+NTWYMLYEAKADHDDLNTVCLATSPDGRNWTKHGPVIEPGDAGEISAVDVGTPTMFKEGG
+QWHVYFHTLAKDGRVRIGYAHGENLQDLTVNQGPLLDVDPQGIEGGTVGARSNVVKVGDF
+YYMAYEVCSPNTDFHRSQWGTNLARASSPGGPWVKMSGRPLLVNDRPGMGMDGPELSLQD
+GKLYLYYRHGANATARVELSGLGDSSKMYLAHQSSPGVPV*
+
+>NODE_4#PROKKA_00205
+MTIKSYDSVYFDGRWQPVDGERLSVYESGTGEVMASIPGAAPAVMQQAIDAAHNAFDSWS
+RRPLKERLKYIEALHGQLVARAEEIATTISREVGMPLKLSRNIQAGLPIAITDSYLKLLP
+DFPFEEKVGSSLVQYTPVGVVGCITPWNYPLHQVILKVVPALAAGCTVVLKPSEVSPLSA
+FMLAEMFDAIDLPPGVFNLVSGLGHVVGDSLTGSNKVRMLSFTGSPGTGRRIFHAAAEDF
+KRLALEMGGKSASVILPDADLATAVKGSVNNCYLNSGQTCIAWTRMLVPADKHDEACELA
+VAAAKKLTLGDPLDENTRLGPLASKEQLERVRNYIRVGIEEGAKLMTGGPDAPAGLDKGY
+FVEPTIFANVDPQSRIAQEEIFGPVLCIIPYRDEEEAIAIANGTPYGLSGGVWSADQDHA
+IAVASRLRTGQVTVNGGAFNPEAPFGGFGASGLGREFGRWGLEEFLEVRSLQL*
+
+>NODE_3#PROKKA_00180
+VKPSGKRFSLKTWSLASLTLAGMLALQPAANAGSLPKRSFCVFDPVGANGPLFNLMKSTK
+PAALDWGVDLQMRAYTDEKIAAEDFKGGQCDSVLLTGTRAREFNKFTGTLEALGAITSNK
+EERVLMDTLNQPKAAKLLTNGDYEVAGILPAGAVYLFTRNRNIDTVNKLQGKKIATLSYD
+RASLTMVRHVGASVVGASSASFAGLFNNGSVDLAYAPAVAYTPLELYKGLSHDGGVLQYP
+LAQMNFQIILHKSRFPKGYANHVREYAREHLNQAFSIINKATDEIKKKYWMYPTDKQTAS
+YDQMLQSVRLSLRDKGVYDAKALKLMKIIRCKVQPSRGECSQNAE*
+
+>NODE_29#PROKKA_00105
+VEGLFDKLSAIQKFANDLRGNRSGVLSIASTPTLTYAFLANALKRFREERPGVRILLEVT
+HTQRTLELASAGQIDLGFIHGPSENPLLQFERLAASEMVCVLPPDHPLAAQPALGPRDIS
+AFPLITNIRNSIAPRIEEAFRKQGVERDFAIACNHTMTVYMLVEAGAGIGLVDPWVQAER
+FPTLVRRPFRPRVEVSPRAVHSRSQSLSRLAEGFLAVVREEAAVSQ*
+
+>NODE_2#PROKKA_00129
+MSVLMHNNQDGAVRFVFNNLSNKQTKQKSAETLKKLDLYKTMSKFKSTGVVYFFDAKNKS
+LISHISLARSNKQLAEALTNSEKMAK*
+
+>NODE_3#PROKKA_00164
+MTDLPRIAFLGIGLMGRPMATNLINAGYPVTVWNRSPEKARALAGQAGVAESAAQAVAQA
+DRIITMLENGDAVQQVLVEQGVAEAIQPGAVFLDMSSIAPEMAKSHAGRLKARGVGYIDA
+PVSGGTVGAEQATLSIMAGGSHEDLEAVRPLLETLGRVTHIGPAGSGQLAKLANQAIVGI
+TIGAVSEALLLAAKGGADPEAVREALLGGFAGSRILELHGQRMLARDFEPGAPSRIQLKD
+MRMILDQARAEDLTLPLAQQAFQSYRALIALGEGECDHSALLLQLEHLNQTRMSDPSDGQ
+ER*
+
+>NODE_3#PROKKA_00195
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_3#PROKKA_00160
+MNTQKLINRALSGLDDLGYQLDSMGITSKVNRHNVIAYVMAEQKHWEGEYDSLVARIDQQ
+RFRVEQIVGRVEGLVRGGAEFALKPVSGLRSLVKA*
+
+>NODE_10#PROKKA_00012
+MSAEDPIIEVRGLKAQFGEQVILRGVSFAVARGEVVVVAGGSGCGKSTLLKHMLGLYQPA
+AGSVLIDGVDIAQADAAQLEWVRRRIGVLFQSGALLGSLTLLENVMLPLVGFTPLSRRGA
+ELVARLKLSLVGLSGYENHLPSELSGGMQKRAGLARAMALDPQVLFFDEPSAGLDPVTSA
+ELDLLIKRINRNLGTTMVIVSHELASIFEIAHRVILLDKQAKGIIAMGPPQELSGVPRLF
+PGGIL*
+
+>NODE_3#PROKKA_00173
+VPELPEVETTRRGIEPHLVGHTVTQLQVRESRLRWPVPDKLDQMLPGQKVGQVARRGKYL
+LVHLERGTLLVHLGMSGSLRVVTRAEALRKHDHIDLTTDAGTIIRFNDPRRFGAWLWTED
+WQHHPLLASLGPEPLSPAFSGHYLHRQSRRRKAPIKQFIMDSHMVVGVGNIYANEALFIS
+GIDPRRPAGRISAARMEALVLAIQQVLENAIAVGGTTLRDFVNSEGQPGYFRQSLQVYGR
+EGQPCRRCGKPLRQLRLGQRSTVFCGHCQR*
+
+>NODE_8#PROKKA_00293
+MNIYVGNLPYSVSDDDLRTAFEEYGAVDSARVIMDRDSGRSKGFGFVEMGNDNEAQAAIE
+GLNGQDLGGRPLTVNEARPRADRGPRRGGGGGGFDRRPRY*
+
+>NODE_8#PROKKA_00291
+MVGTSVTLLLRFAPWRGSFFLYFQALAIDTGERGTDTPGSAPMAQLQTRTTQVIVQNQLG
+LHARPVTLIVKLAKTFSSRIAFERGGTVSDAKSVMALLLLAAGKGTELTITAEGHDAEEA
+IEALERLFSDKFGEE*
+
+>NODE_7#PROKKA_00268
+MSMKVTTRQVDGVTILDLSGRILLGEGSVQLRDAVRDLLAKGQKKILLNLGDVTYIDSSG
+IGEMASALTAVRNQGGDLKLLNLTKRVHDVLQITKLYTVFDIKDDEASAIASYN*
+
+>NODE_1#PROKKA_00088
+MEKKITGYTTVDISQWHRKEHFEAFQSVAQCTYNQTVQLDITAFLKTVKKNKHKFYPAFI
+HILARLMNAHPEFRMAMKDGELVIWDSVHPCYTVFHEQTETFSSLWSEYHDDFRQFLHIY
+SQDVACYGENLAYFPKGFIENMFFVSANPWVSFTSFDLNVANMDNFFAPVFTMGKYYTQG
+DKVLMPLAIQVHHAVCDGFHVGRMLNELQQYCDEWQGGA*
+
+>NODE_3#PROKKA_00185
+MIDTCEAARQLQLNAAGSLRHFLTLDGLDRPLLTEILDTADSFIEVGERRIKKVPLLRGR
+TVVNLFFEASTRTRSTFELAAKRLSADVLNLNISTSAASKGESLSDTLLNLEAMASDMFV
+VRHAQSGAPHFIARHVTPGVGIVNAGDGRHAHPTQAMLDMLTIRQHKGGFEGRVVAIVGD
+ILHSRVARSQIRALEILGADEIRVIGPNTLLPRDVESLGVKVFNDMQRGLKDVDVVIMLR
+LQNERMEGALLPGEREFYRLYGLTTEKLRYAKPDAIVMHPGPINRGVEIESAVADSPRSV
+ILNQVTNGIAVRMAVMSMVMSGQLAQLNQGDAAQEQSRTL*
+
+>NODE_6#PROKKA_00250
+MKYLIAGLGNIGVEYANTRHNIGFIVADALVNELKGKFETERLASVASVKHKGRTLVVIK
+PTTYMNLSGKAIKYWIDKEKIPIERVLIVVDDIALPLGTLRMRKKGGAAGHNGLSDIIMK
+LGTEKFPRLRVGIGDDFAKGYQVDFVLGQWTDKEVNVMIPRVQKAVEIVQSFVSAGIDNT
+MNLYNNK*
+
+>NODE_1#PROKKA_00059
+VVFVRLNLDAVTSNNKASDPDYFFFPASIFEKSHRHERMPKFILKDLSDYQQYRDNRELI
+SSFFENLPNKTLQLIAKPLCGSSAAKLIALVAFAVL*
+
+>NODE_7#PROKKA_00281
+MYPFIHIGHFTIPTYGIMMWLAAVAGCIVLYRNFKRWKVEGDAITIVAFATVIGIIGGKL
+YHVLEKPVLLMHHPALLISRSGFAWYGGMIAGILALLFQAGTYNIRPLRMLDLCVPSAAL
+GYGIGRLGCFFSGDGGYGPPTKMWFGMSFPHGTVPTTQKVYPTPLFEFVAAVIIFYILWR
+RSRPAAERKLGHMTAEYLLLAGGARFLFEFIRINPKIFLGLSNAQWASIAEMLGGTALLW
+WSRKYASTPQPGQQGRQPKEEPALVAAGDSGGPPTAEQTQ*
+
+>NODE_6#PROKKA_00251
+VFQGKHQLNVFINILTQIKTMLRIRNFNNFVSNFLKIFAKFYNQAKIISYRLIILLQASV
+TGQPNHSIEMEKQRQQSGLLFKIK*
+
+>NODE_11#PROKKA_00016
+MSKLFGILAGLIGIFLLVASVISFGHLVEDAWVRGGMLASLLFALLLLLGSAAFLLTAVL
+LFRMRSHYLPRLYELEELEGLEEPPPKTKDSGESNGPRLA*
+
+>NODE_2#PROKKA_00137
+VLIKKAMNRVERGKYGEVHSVLIYKDGKLVLDEYFKGHDYKWEAKKHYGPMVVWDADRAH
+SAHSVSKSITSLCVGIAVDKGLIKDIHQSIFDYLPEKYQYLNVGDKKYITVENLLTCSSG
+LLWQEWSAPLSSKRNDQVGIYFHKKGPLDFVLNRPFVAVPGQRFNYSGGGVEVLGEIVKN
+VSGMAFDEFSQKYLFEPMGIKTASWALKYPTGEVHAAGSLKIRPRDMIKIGAMMLNNGIW
+NGKRIVSEDWVEKSRKPWGNNRGIDLPGEDLRDMGYAYNWWTKNEKINGKAVHWFSANGW
+GGQQIIVLPEINTVVVLTGANYNRKVKQYALLADYIFPAIK*
+
+>NODE_9#PROKKA_00318
+MAKTATKKGETAQTKITGKIQKAAESVTDKVKGYNEKYVAKNIEKGKATLKEYNEKYLVK
+TVEKGKDTLKEYNDKYITKAVEKGRSYVDGPYKKLSGTMDQWLEKGRSFEKDAWKKMDGY
+VENGKKFMYKLPLVETVEKKVTSSLNSVPSVVNLPGKGDIEKLTLAMEALNSNIEALRKQ
+SAQ*
+
+>NODE_3#PROKKA_00163
+MPRLAANLSLLFNEVPFLERFEQAARAGFRAVECQFPYAWAPEAIAAQLQGQGLQQVLFN
+LPAGDWDGGERGIACLPGREADFREGVERALRYAEIMKCRQINCLAGPLPTGAPPEPYWA
+TFEANLRWAAPRLAEQDITLLIEAINSKVDVPGFLLDHSKLALDLIDRLNLPNLKLQYDL
+YHMQIMEGDLLRTLGANLPQIGHIQFADNPGRHEPGTGEINFRRIFEQLDAWGYEGWVAA
+EYVPEVGTFDGLSCLKSWL*
+
+>NODE_4#PROKKA_00208
+VIRDKETLNQLIDTISRFVRERLVPSEEQVAQDDAIPEDILQEMKDMGLFGLSIPEEYGG
+LGLTMEEEALVAMEIGRTSPAFRSIFGTNNGIGSQGILIDGTDEQKRRYIPRLATGELIS
+SFCLTEPDVGSDAGSLRTTATRDGDHYVLNGTKRYITNGPEAGLFTVMARTDPDNKGAGG
+ITAFIVEGDTPGLHRGRPDRKMGQKGAHTCDIIFDNCRVPAENIIGGREGVGFKTAMKVL
+DRGRLHISGVCVGVAERVLDDALHFAMERTQFGKPIAEHQLIQALLADSKSEAYAGRCMV
+LDAARRKDAGENVSTLASCAKLFCSEMVGRVADRAVQVHGGAGYMAEYAVERFYRDVRLF
+RIYEGTSQIQQLVIARNMVREAD*
+
+>NODE_25#PROKKA_00101
+MSLPKRITAPLLSGLVLPGLGQLINRQLGKGALLICLMSLFFMSFLFLTVYQVSHAMSAL
+GEAAAQSADKWQALRAQLARQGTGWLWGLGTAGLGIWLFAVIDAARVGARLDRSAAEGGQ
+GES*
+
+>NODE_12#PROKKA_00033
+MSNRDIHNATGDSVKMNALVLGAGLQGKAVIHDLSRSELVDRILVADLDLAAAQRFLDKG
+GYHKVRAVQADALDPAVLRRLISENRSDIVVCMLPAHLSGRIAEVCVECGVPFVNTSYAQ
+WLGELDQRARDKGVILLPEMGFDPGIDLIVGRMALDELDQVEGFYSYGGGLPDPAACDNP
+LKYKITWTFDGVLKAYCRPARLLRQGRPVEIPGDEIFQEENIHFIEVPELGRLEAYPNGD
+ATRFVEVFGLGPELKEMGRFATRWPGHSAFWRIMAKLGFLGDQPVELGEGVSVSPREFLV
+KLLEPRLQFRENERDVVVLRVKVWGRRGGRKRTVTYDLVDYRDLATGLFAMNRTVGFAAS
+IGAQMVLKGEITGAGVLSPVKVVDGQRFLDELAARGIKVQRRLEEE*
+
+>NODE_11#PROKKA_00023
+MESEVLQRVAEMLRSPGAVARNRNLLEFESEAGQRAWRCYRLFLSLLAELERAAQSPEVR
+VSAQETEGGLQLVLVDPRVSYRRSCLVPPELVELFLDKLTALGLLGGEKT*
+
+>NODE_3#PROKKA_00176
+MTAHSDQQQQEARIRLDKWLWAARFYKTRTLAKEAIEGGKVHYNGQRTKPGKVVELGARI
+RLKQGWAEKEVVIQGLSDRRGGAPQARELYQETDDSQQRREDEHWQRKMMQAAQMPPARR
+PNKKQRRELQRLKSGQG*
+
+>NODE_2#PROKKA_00133
+MSQLANDHKAINLSQGFPDFPISEELIDLVHYYMRKGYNQYAPMQGVLPLRKAISTMFQK
+NYGIHYDPVSEINVTAGATQALFSAISAFIKDGDEAIIFEPAYDSYAPAVKINGGMVKYA
+HLEFPDFNINWEDFPRLITNRTKLIIINTPQNPTGSVLSEDDLQRLERITSGTDIIVLSD
+EVYEHLIFDGITHQSVCRFPELAKRTLVIGSFGKTFHATGWKTGFVLAPERLMKEFRKVH
+QFTVFASNTPIQHAIADFIGNEDNYKNLGKFYQQKRDMFVKSLNGSKFNVLPCYGTYFQL
+LDYSNISDKNEMDFARWLVEKHNIAAIPIAPFYHKKDDHKVLRFCFAKKDETLVEAGEIL
+SKI*
+
+>NODE_42#PROKKA_00197
+MNMVENMLDQAFKKLNPHEHPVLHSDQGWQYRMRRYQNILKEHGIKQSMSRKGNCLDNAV
+VECFFGTLKSECFYLDEFSNISELKDAVTEYIEYYNSRRISLKLKGLTPIEYRNQTYMPR
+V*
+
+>NODE_1#PROKKA_00064
+MDTIRIRGARTHNLKNINVELPRGSLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
+ARQFLALMEKPDVDSIEGLSPAIAIEQKASSHNPRSTIGTVTEIHDHLRLLFARAGTPRC
+PHHGLTLDAQTVSQMVDTVLADPSERRVMLLAPVVHGRKGQYQELLEDLKSRGFIRARID
+GTVYELDPLPRLDGHQPHDIEIVVDRFRIRSDMAARLAESFETALALADGSALIADIDKP
+HTSEMVFSARHACPQCGWSIPELEPRLFSFNNPAGACPQCAGLGRESYFDPGRIITQPSL
+SLAGGAIRGWDRRNPYYYRLIESLARHYEFDTEAPWSELSERTHRVLLYGSGEEEIDFTY
+VSARGQKQQRRHTFEGVLNILERRYHETGSQAVRDELVRYQSSRACTACNGTRLGEIARN
+VFIADTTLPDISNLAIDAVWRFFNDLDLPGRRGEIAKRIQHELHSRLGFLVDVGLGYLTL
+ARSTETLSGGEAQRIRLASQIGSGLTGVMYVLDEPSIGLHQRDNRRLIDTLTRLRDLDNS
+VIVVEHDEDAIRSADYLIDMGPGAGAHGGEVVATGTPEEVMNNPNSLTADYLSGRRTIPV
+PQARRHPQPGQAIIIRDAHGNNLKHIEVSIPLGLFTCVTGVSGSGKSTLVLDTLQAAGER
+LLNRARTEPAPHASIEGLDALDKVIAIDQSPIGRTPRSNPATYTGVFTAIRELFAQTPEA
+RARGYKPGRFSFNVRGGRCEACQGDGLVKVEMHFLPDIYVPCDLCHGSRYNRETLQIHYK
+GRTIEEVLNMTTEQAREFFANIPSIHHRLDTLVTVGLGYVKLGQSATTLSGGEAQRIKLA
+RELSRRDTGRVLYILDEPTTGLHFHDIRQLLAVLLRLRSHGNTVIVIEHNLDVIKTADWI
+IDLGPEGGHGGGQIIGEGSPEDIARLEHSHTGHYLMPLLKPHKLQKETTT*
+
+>NODE_22#PROKKA_00098
+LGEPLGSFEGETQTVMSVGDLAYWEPGNAFCIFFGPTPASSGPEPVAASQVYPLGRVEGD
+WQALSALGASVTARISAA*
+
+>NODE_3#PROKKA_00156
+MSHTSSDHSIAFPLRQKSKLRHLAQELLAKADIRIDGDRPWDMRILKEGVLERILGEGSL
+GLGESYMDGEWDAERVDEFVYHLIRAQLDREVRPWNLILHGLRYRLFNMQSLRRAWMIGQ
+RHYDLGNDLYEAMLDPLMTYSCGYWKTATHLAAAQEAKLELICRKLQLKPGMRLLDIGCG
+WGSLMAYAAQHYGVECVGVTVSEEQVKWARHQYKGLPVEFRLQDYRTLDEQFDCIASVGM
+FEHVGHKNYREFMQVAHRCLDDGGLFLLHSIGNNSRDSGSDPWIDKYIFPNGELPSVGQI
+GDAADDLFVIEDLHNFGADYDKTLMAWHANFEAAWPKLAYLGERFRRMWTYYLLSCAGTF
+RARDIQLWQWVLSKRGVQSGYIRPYF*
+
+>NODE_4#PROKKA_00202
+MSVLKAQGLYKRFGGLQAVNNVSFSVDRGEVLGLIGPNGSGKSTTLSLLMGVTRPDRGSV
+QLDGQEMAGWRTHRIAKQGLSMVFQHSRPLHRQTVLENIKLALLPDTLWQLFPPHTLDRR
+AREIAERVGLHNVIDTLPGNLPFADLRRLEIAKALAQDPSVLLLDEPFAGLSPRETREFA
+ELVHLFREEGRAVILVDHNVKEVAGLVDRIVAMHAGQVIAEGTPDEVTRDPKVREVYFGQ
+SLENASGIHADGDRRSEGNGSEALLEIDLRSVRYGLAEALRDIQIQINQGECVSVVGING
+AGKTTLFKSILDFQGYEGDVRWQGTSLTGQGPGQVASQGIALCPESRELFGFMTVRENLE
+LGGHKLDRQAHESQMDRVFDLFPVLRQRQAQAAYTLSGGEQQQLTIGRALMQQPKLLILD
+EPTLGLAPLVIENISEALHKLQQDSGMTLLLGEQNLTFALRHSQRIYLLETGNLRWHGPA
+ERFIEEVGEDVL*
+
+>NODE_2#PROKKA_00126
+MQEYIKTDRQIHWLSQAIAKVNRDYVPAKKDDSHTNLFLDAAGKRLFGRWINTPKGKFIL
+ALNLKTLSFEWLDNPLSVKTSISVFDKEGSSIEKEIREFPVSMGMSSKDISKPLHFEIPD
+YGFSIIKSNRISSFGIKQWIYYRGLANFACLSVLGYLQSESEIRIWPHHFDTGVYAQVTD
+SLGFGFGWAMADSMIGEPYYYLSGYKNSSIIIYNNLSKLNFGRWVTGEQWNGTVLPLHVL
+ADNSTAKALEIINTYIKESIDWFLNL*
+
+>NODE_11#PROKKA_00019
+VNYEPCVKHKVVRNTVRDFAEAELRPIAHEVDQNSRFPWEVVEKMRGLQYFGLQAPRELG
+GAGLDSISYAIAIEELSRVCAGIGLCVTVHNSVALYPLLKFGSPEQIERLALDLISGRRI
+GAFCLTEAGAGSDAGAVETLALPCDEGYLINGTKIFVTNGGVCGLALIFAKTDLDHPRGA
+PSVLMVEKERSGFAVGEIEDLSGMRCNPVSSLFLEDCLVPPENLLGRRGDGLRIGLSALD
+TGRLGIAAQALGIAQGAFEAAVRYAKERQQFGKPIARFQTIQNYLADMATKIDAARMLLY
+RACAAKDQGQPFSAEAAKAKLFCSATAREVCNLAVQIHGGYGYSKEYEVERYYRDAKVTE
+LYEGTSEVQRMVIARAILSAPA*
+
+>NODE_8#PROKKA_00298
+MTAFPRTDVGGVSVSRLIIGTNWFLGYTHSTSAQSRTNSERVNHRDVVAGIVETFVEFGV
+DSIMCPHTDTVIPEAIEEARQRTGKPLVVISTFALPVTKRTALDGFDLGEVERILDEQVA
+RDVDIAMPHQSVTDIMLDKCSREIRQMAPVCALIRDRNMVPGLSTHAPETVIYSDETGLD
+VESYIQPFNLMGFLMQVEVDWIARIIQNAKKPVMTIKSMAAGQVRPFQALTFSWNVIRPQ
+DMVTVGTSSKHEARELCEMSLQILDRRATTQELQRTRSKASISPA*
+
+>NODE_7#PROKKA_00261
+VKKVWLSWSSGKDSAWALHILRQQKDVEVVALLTTLNEHFDRVAMHSTRRDLVEAQARAA
+GLPLVRVPLPWPCSNEQYEAAMGKACAKAVAEGVEAVAFGDLFLEDVRQYRVEKLAGTGL
+EPLFPLWGLDTRALAREMIAAGVKTRLVCVDPRKMPREFAGRDLDEAMLRELPEGVDPCG
+ENGEFHSFVYGGPMLGEEIPVESGEVVERDGFVFADVKLKH*
+
+>NODE_17#PROKKA_00044
+MWQEHIAGRKIGLETGPRPFDPHKPCLLMVHGSGGRGETFRPQLSGLAPYLNPAAIDLPG
+HGNTPGPGRDQVAHYADWLAEFIRRGPLRPALLGHSLGGAIVMQLALDHPDLAPALVLVG
+TGSRLRVLPAILDGLLSDFDATLDLVLKYAYAPGADPRWVQAGREIMSQPGPRVVHDDFA
+ACDRYDITDRLGEITAPTLLIYGDQDQLTPPKYGRFLAERLPDARLEIVAGAGHMVNLER
+HAEVNRLIHPFISAFSPPASS*
+
+>NODE_2#PROKKA_00115
+MAKQKTQEKIWYAIYVKSRAEKKVAIELEAEGIDFYLPLEKRLKQWSDRKKWVEEPLFRS
+YIFVHISHKDYYRALVQNTVKYVTFEGKAVPVPPEQIEAVKVYLEEKEPIQPNDEDWETG
+KEVEVISGKLTGLKGVLMEVKGRSRVKVEIEVVSSSIILHIPKSKLRLLE*
+
+>NODE_7#PROKKA_00264
+MKTCIDPVVGDILSSWRYDISGITPEMRIDYEEHLASCSVCRSRQRLHRAIDVVLIGLTT
+LSTIVFVLALAVIHHVEPLRTFALFIFHIRDFSVVLTLQAVAFAGLVVSMFAWLLVAVAT
+PVPTFLSGVAREQARELQSRIPEEWRNRFQRGAL*
+
+>NODE_1#PROKKA_00070
+VTETMARFRRTKIVATLGPAVDEGDVLARMIAAGVDVVRLNLSHGTHAEHRKRVKAVRKA
+AAEQGRDVGVLIDLQGPKIRIECFRDGPIELKEDDAFTLDCGLGSNAGDSKRVGVAYKNL
+PRDVQAGDMLVLADGEIVLEVREVIGEQVHCRVETGGALSDHKGLNRRGGGLSAEALTQK
+DQVDIQLAAELEADFLAISFPRVAADVERARALLRAAGGTAAIVAKIERAEAVENLDEII
+DASEVVMIARGDLAVEIGDAPLPGVQKRIVRHARARNTVVITATQMMESMVTSPTPTRAE
+VLDVANAVLDGTDAVMLSEETAVGRHPVKVVEAMARVCLGAEAEPREDRDRRIGGDRFEL
+VDEAISMAAMSVSQHTDVTALVALTESGRTPLYMSRVRSGIPIYALTRHECTRRLLTLYR
+GVYPIAFEDEHESDEVLPDVAAALLERGLVTPHALIIVTRGKLRHVSGGTNSLHLVQVAD
+VLPEQVL*
+
+>NODE_9#PROKKA_00312
+MFQFLLFVGSITAFIIGGLIVLIGIGAITGCAGGILAMCSGAIIAVLGAWSAITFFLPSP
+DPSVPARETINLIRRNGRWM*
+
+>NODE_4#PROKKA_00217
+MGELVDVYRNSVQTWECDQMGHMNVQFYLDKADAGLLALTRMLGLNRRFLNERQARVRVL
+ENHVRFLREQHAGSPLTLRAGLIDIRPDQLKLYFELTNPIQQAVAASFITQAVLESTAGK
+DHLTLPQSALEKAQQYQIDWPRPEGPMGLESTPPRTPPTLQEADDLGMMPTYLGAVSAGM
+CDADGHLAIRSYMGIVSDAVPHLLSRIRHDTREVPRPGGAALEYRWIYHQRPEQGDLVTL
+RSAITHLGNKAYRLGHWLFDAETGHCLATTEAVAVMMDLDERKALVIPQTARASLEEMLV
+KGFSI*
+
+>NODE_10#PROKKA_00011
+MAHGQEPAYEMKSEPAGNGELRVDLSGRLDMNALEGAVDQFGRLLKEQRPRRVELAVGGI
+DYLDSGGALALTLMEEAARKAGTKFQLVQAGPEVRGMLALVDMDKIRRRPLRPAERGLGF
+VEQVGQASLEVWRDFVELVTFLGDFLIALGRSLRRPRLVRWQETFFYMEQVGVNGLPIVG
+LISFLLGLIIAFMSSLQLKTFGADAYVAALVSVAMVRELGPIMTAILVAGRSGSAFAAEI
+GTMRVNEEVDALEVMGFDPTDFLAMPKVLAALAVVPMLTIYSCVAGILGGMVVGIWGLGL
+TPYTYLHHTIDSLSAYGIVTALIKSVAFALIIAGIGCQRGFMVRGGAQAVGSATTSAVVT
+AMFLIIVADSAFAILFYYVF*
+
+>NODE_12#PROKKA_00027
+MDQSKALAKYREFRPAWKSFLPYFLGVVIFTVGPRVNPQAPISPDLSHLIATCFLAFILI
+TRFSNLYELADGRLGWRRSFPRALERQAPVEQITRIDLRRGIFHRLAGVAHVHVYLENQQ
+EPYLKLFGVSEPEELRRLLLDLGASDQRVTGAWRK*
+
+>NODE_2#PROKKA_00123
+MKAIWNNTILAESNDIVKIEGNAYFPINSVKKEYLKTSETHTVCPWKGTASYYSLEVNGK
+ANPDAVWYYPEPSDLAKGIKGRVAFWKGVQVVKD*
+
+>NODE_2#PROKKA_00139
+MELNVQIDHVHLVVSVPPKVSVSRLMGILKGKLAIKLFKSYPSLKEKPYWGNHFWARGYF
+VSTVGIDEDVIKRYVKYQEEEEKKIETQQQRFDF*
+
+>NODE_7#PROKKA_00276
+VTTANTFRANWPFVLIAAIFLGTALVGALTGRIWLQMRTITRTNDKVMYWATIWCSVIMA
+GFMLLVAAHYAPVINLIKEL*
+
+>NODE_13#PROKKA_00042
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_7#PROKKA_00280
+MPDQTQFPPAESLRIRFTRDQIQSRVREMGRHIREDLHGESVVLVGVLKGAAIFLADLAR
+AINLDCTFDFVAVSSYKSGTRSSGAVQLIKDLTEPIEGRHIIVVEDILDTGVTLSFLQSH
+FERHNPRSIRVAALLDKPSRRIRPIQGHYIGFSIPNEFVVGYGMDYAERYRNLPDIRILD
+SIPAS*
+
+>NODE_1#PROKKA_00077
+MQNTITGRHLDVTPALKDYVNTKLSRLGRHHEPPTSTQIILSVENLDHKAEGILQVRGGT
+VYAEANETDMYAAIDILADRLDRQLVRHKERHASHHATPTARLNMEN*
+
+>NODE_1#PROKKA_00085
+LNRLLIRGGGRLDGEIRISGAKNATLPILAASLLAETPITIGNVPHLHDVTTTVTLLRRM
+GVDVTVGEHMALEVDSNTIKDMVAPYELVRTMRASILVLGPLLARFGCAEVSLPGGCAIG
+SRPVELHLKGLSAMGADIDVRNGYIYAKANRLRGARIFMDMVSVTGTENLMMAAVLADGE
+TVIENAAREPEVVDLANCLNKMGAEIEGAGTETLHIQGVAKLEGCYYEVMPDRIETGTYL
+VAGALTGGRVRVKRTRPDMMESVLEKLREAGAEITSKDDWIELDMKGRRPQAVTLRTAPY
+PAFPTDMQAQFTALNAVAEGSGAVTETVFENRFMHVQELVRMGARIQLEGNTAMIQGVER
+LTGAPVLATDLRASASLVLAGLVAEGETVVDRIYHIDRGYECIEEKLAQLGAHIRRVTS*
+
+>NODE_1#PROKKA_00082
+MSTPLAAIRLLALDVDGVLTDGRLWYSETAGEIKAFNAHDGAGIKRLMREGIAVALISAR
+QSPIVTHRARELGIIQVHQGVKDKGHCLTETAQAVGVRLAFCAFMGDDEADLPAFAIAGL
+RIAPANAVARVRDEADWCTQATGGQGAVREVCERLLAARQANAGGKS*
+
+>NODE_7#PROKKA_00269
+LRGQQETRVTYTLASSLDSVDKVEQTAEQMARNAGIDEDEAFRVSMAVREAAVNAVLHGN
+AYAPDKRITVTFENNGSDLIIHIMDQGEGLDPAALPDPLKPENLLSGSGRGIFLIRSFMD
+EVHFKQLHPGTELTLVKHLGTAKQSLQGGNSL*
+
+>NODE_1#PROKKA_00061
+METKTLSGNATPLTDEQWAGLARLGDLGNRLGALVDGPLSGPASAALDRIGALDGQYDLT
+ALAEKLVGTLSALDRAGLLDLLRDNAQFIADNLNTLTPMLDQWLAHIAELPADEFKADAK
+FALALLRKARLVTTFIQEKLAGELTTKAVEVTEFMQRNDTDEAVAEALVQLGRIYRSGLL
+ARLGDLADTVAGLEEGTDLDDQIDVLIKSSTAGGLGTFLIFLKSVSIAMQKVGQEPEPKL
+GGYIGMLHLLRDKEVQKGLRMLTVLPIYLEKRLEKSAS*
+
+>NODE_9#PROKKA_00308
+MSRSFKSAGRMADPSDVAADICPVPAFIPDLMAVNGLADAGFSRLIFFPGMLFGSTEKWW
+GDGGVRPSAHEGLDLCFFETSDGLRYRLDETVSVPAAFDGKIVRIMDDLLGRTVVVQSRC
+APSDAPFYTFYAHIRPDNGLRQGDTLAAGTVFAAIARIVSPKIRLPAHLHITLARANDLP
+PVDTLSWPVMNRLDRSVFLNPLDLLMCDYAIEDDTRFTPGSDAVKPVRRIRQDRKGA*
+
+>NODE_2#PROKKA_00148
+MLAISIVILLILSFQVMPVALGIDSHKMNVFHVASSIFLLILGQVLLFLLGILLGDKFMY
+LMSGFKRFVLFIGFFIIATRMIMEALEIRKGKRTYLLDKAKQFILPSIAQAINTFLAGIL
+FQLLIFNLSKDLIYLGIFALAFSVPFIFIKNEKQSMLAVSLLYMVGGGILSILSFYFLFI
+*
+
+>NODE_1#PROKKA_00056
+MRHRNSGRALSRTSSHRAALMRNMSKSLIEHEQIRTTVPKAKELRRVVEPLITLAKSDSV
+ANRRLAFSRLRDDAIVAKLFTDLGPRYRERPGGYLRILKAGFRPGDNAPVAIVQLVEEQE
+TTSAAT*
+
+>NODE_12#PROKKA_00031
+LTTLETLGRFAAGLKADELPPRLGEAVNRCLIDLLGAACAGHGSGAARMVRAVAGPLFAA
+GPAWLWFSGRRLASPGAALANAAAASAWDLDDGHRAAAGHPGAAIIPACLAAAQETGASA
+RELEAALVLGYEVACRVAAARDLARLPTMASGRWVAYGVAAAAGRLHGLDAAGLAQAMAV
+AGVLSPDLAAAGYSRLMGNLVKEGIPWATLTGLVAVKLAAHGFSGPLDILDHPDYYQAPG
+ITAGLGGGQWAIEQVYFKPYACCRWCHAAIDALLALQDEQGLDADEIAEIQVHTFERALR
+LSNETGPATLEGAQYSLPFTLAVAAVEGAAGLLPLRPELLGREDLVELAGRVRLEVDPEL
+EAMFPERSPARVVAMTRSGRRHEHTVLDPLGDPANPLSTARLEEKFRALTAGLLPPSRQQ
+ALLVRIHALEPEGLPPLLEELGRPLQPEK*
+
+>NODE_1#PROKKA_00053
+MAKPAAKARKRIKQQVVDGIVHVHASFNNTIITITDRKGNTLSWATAGGSGFRGSRKSTP
+FAAQVAAERAGAVAQEYGVKNLEVEIKGPGPGRESAVRALNNLGFRVLSISDVTPIPHNG
+CRPPKKRRV*
+
+>NODE_12#PROKKA_00030
+MIGKRIRLERVMDRGTRRTVLVPLVHGVGMGPIEGITDVLNTVDTISMGGANAVVLHKGI
+VAAGHRRGGADIGLVIHLSATCADGSQTLVTEVEEAVCLGADAVSLRIEVGGADEDESLA
+LLGAVSRVAADWGMPLLALMNPAPIPPAKMPKLLMRAARIGAELGADVVLVPYHKRFAEV
+VAATPVPVVAIGGVKKTPPKQMLEMARAAVDAGAYGVSVGRTVFQYEKPGNMIKAICQVV
+HRKATVKKAMEILAKKPIESTLYGGTVIW*
+
+>NODE_1#PROKKA_00065
+MAGSGKLRKDAGIIGLLYFSLGGIIGSGWLFGPFDAAKAAGPWSIASWIIGAAVVMLLAL
+VFAELATMMPKSGALIHISHIGHGELIGRIWSWILFLSSVVTPPIEVMAVLTYLNNKIPY
+FVDPSTHVLSTIGFFAAIVLLGVVVVVNFFAIRFVLWINNIATWWKMFIPAISIIVLMSY
+SFHPGNFHLDLGSVNAAGMLTAVSTAGIVFSFLGFRLAINLGGETKNPGKYIPIAVIGSV
+LIATLIYVGLEVTTITSVRPSDFANGWPSLAFKGDAGPFAALAVTIGAVWWSWVLYADAI
+VSPFGTGLIYTTNTSRLGYAMAEVGSAPKKMQKLSRQGVPWISLLVTYVIACIFFFPFPS
+WHQLVGYVSDITVLSYGIGPVVLLIMRKRRPEEPRPFRLKGAKVIAPMAFIASNWVIFWT
+GCTTVTFLFGLLGSLFAVYAIWYYIIARKPSKEFGWKYAWWVFPYFIGMWLLSYIGPSTL
+GPAHVSLFNVQPLDILPLGWDMIAVAVFSLAVLYTATSSALPREEADRYFDELKKLNLPE
+EYSEGTESP*
+
+>NODE_1#PROKKA_00090
+MAETAVINHKKRKNSPRIVQSNDLTEAAYSLSRDQKRMLYLFVDQIRKSDGTLQEHDGIC
+EIHVAKYAEIFGLTSAEASKDIRQALKSFAGKEVVFYRPEEDAGDEKGYESFPWFIKRAH
+SPSRGLYSVHINPYLIPFFIGLQNRFTQFRLSETKEITNPYAMRLYESLCQYRKPDGSGI
+VSLKIDWIIERYQLPQSYQRMPDFRRRFLQVCVNEINSRTPMRLSYIEKKKGRQTTHIVF
+SFRDITSMTTG*
+
+>NODE_4#PROKKA_00211
+MKPFTWEDPLLLDLALDSDERMVRDSAHDYCQNKLMPRVLEANRHEVFHREIMNEMGELG
+FLGPTIPEQYGGAGVNHVCYGLIAREVERVDSSYRSAMSVQSSLVMHPIYSFGSETVKQK
+YLPKLASGEWIGCFGLTEPDHGSDPGSMITRAKKVDGGYRLSGAKTWITNSPLADVLVIW
+AKLDDTITGFVLERGMEGLETPKIEGKFSLRASVTGQIMMDDVFVPEENRLDVTGLKGPF
+SCLNKARYGISWGSMGAAEFCWHAARQYTLDRKQFNRPLAANQLIQKKLADMQTEITLGL
+HGALRLGRLMDSGDWAPEMVSLLKRNNCGKALDIARTARDMHGGNGIADEYHVIRHVMNL
+EAVNTYEGTHDVHALILGRAQTGLQAFTG*
+
+>NODE_6#PROKKA_00257
+MEGDIINLNDEHRSTARKIVAPLIEEIKNCQTIYTFSVAGESGAGKSITAAAIAEQLELA
+GFSVKVFQQDDYFFLPPFTNDQKRRKDLEWVGIKEVDLALIDEHLKAAKDGVKTIKKPLV
+IYGKNKITSEVFDMKGVNVCIAEGTYTSLLKNVDKRIFIDRDFFDTHNDRKKRGRDLIDP
+FTEKVLEIEQCS*
+
+>NODE_10#PROKKA_00009
+MPIPGRLLTTAMAVMPHTDVDQALASALSLDIPFWPQLPRVNYYEDMYVQASEHFPGMVV
+DHKERTLVFSMDKFMVELEETLAHLEEPEYFDISPEYSVVYHRFLELELADRPAIRGQLE
+GPISFGLNVKDQDDRPILFDDTVRPFLLEVMARRVNVQLTRLKARNPNAFMFVDEPGLQF
+IFSGLSGYSDRKAKEDLDQFFAAIERPRGIHLCGNPDWDFLLNLDLDILSLDVYSNGEVF
+SSYARSIKRFLDRGGVLAWGLVPTNFEPFSAEDHVSLKARLKEIWSALESKGVDRELMLE
+RSLLSPATCCLVNPDGEKTVDKAFALVRALSAELRDEYGLDG*
+
+>NODE_1#PROKKA_00066
+VQATDWLHQIAGPALVLNFADGTVIDINAAGRRLVGIEGQGLIGQDFCGFFVSSDADCCW
+PTLQRSINLQGGFRYEGLHLRTPGGAMRRVNVSAELLQSEQERAVLMLLQPGTASSPQAT
+DHEKELAQYATVGLYRLDAEGRLTHANHALARLLGYETVGQLLDSAAVQRSQWYVCDGVS
+EERVSDVNDAAIYRCKVQLRRAHGAAFRAVEAIREIRDVRGQLMSRIGTLREISDQSSSE
+QALAISEDKYRSLVEHSQDGVFVIRDGVYVFVSQVYSSMLDYAPEEMVGESFLRFFAPED
+RQKIVDVWHERQAGHWEQGAYEAHLLKKDGTRVLVSVRAGPIRFAGAMASTGTVRDITAY
+RDTQQQLSMAEQRYRDIFEHAVIGIYQTAPDGRLLAANPAMAQILGYDSVEELQEQVDDV
+GELFFDRIERDTLIEKLEAEGRMYGAELRLRHRKGTQLWVQDSARVVYDANGKLVCYEGM
+VADITARKIVEQALHRSEQLFRTLVEHTHVGVIMVREGVVTYANRALAHMLDYAESDLLE
+QPLASLFAPESRDCVERLEQELKTAVGSNIYESSMLAADGTRRVRANLSVASVIFEDNPV
+MIITAHDLTREKRAEARLRRLATHDPLTNLPNRVVLRERLAQVLKKTRETGNVDWAVLFL
+DLDAFKLVNDSLGHAAGDELLRQVAVRLRRAVRHDDLVCHHGGDEFVVLAFNITHEIDAV
+ELAEHIETAMAEPFRISDHEIYNQITIGIALGRQEYELPEEVLRDADSAVAAGKRLGKVC
+HVVFSSSMHVAAMERLELETTLRAGLTRGEFDCYYQPIFNVKNNRIESLEALLRWHHPEQ
+GVLRPHSFLQVAEESGAIVPLGWIGLRRALAACSQWQSLGLEREVSVAVNLSDAQFRLPQ
+LPEQLAHELEQAQLPFHLLHLEVTERVFLETPGLARRTLGRLHALGVKLYLDDFGTGYSA
+LSYLRELPFDALKDRS*
+
+>NODE_9#PROKKA_00324
+MTNATNDQPFRPARFTEQRLITAILDGTCPPGSVLPAERRLAEQFGVTRPTIRETLQRLA
+AEGWITIRHGKPTRVNDFWETGGCS*
+
+>NODE_25#PROKKA_00099
+MMYGDSSAGAGIEAQSLLCPRCGKAQPVRKKLLLVLPEGDKYAYFCAVCGEEVGSKLEES
+QGGPSFIPR*
+
+>NODE_9#PROKKA_00309
+MGLFSIFGGKPPEELERRGDFHYEAGAFGDAKMAFEKAIDRIERRFPEKKHLLPRIMEKY
+HLARNALAKMHVENGDHMITVRDYEEAGALYRLAMELTSDEAFAAEIHGKIAKLKDLIAD
+EDEPEMEWVGDAREEAYVDDWGGAEEDAGGAEDDDAYADDDMTADAEGMADETDADAQLY
+DSPENLFHVLVSALPEAVQDAYLGYGEAFAAGYIALNHGEFRKAVKELSRALEENASAKT
+LIPVELATAYMHLNDPDHARQILEDFLKENPGEIRGYQLLCEILWEAGNTADARNLLSGA
+PNDIQTTRPMQMLQGETLFQVGLYDEAEKVFTRCLEIHGKDEIVNRGLAKTYEAKGQIEK
+ARDLYADILNRCIMCGSAADPIIKRRYADLCIKSGDKSLKLLELYFGLAKEDPDNRADYF
+FRIADLYEAQGKDIEARKYRKLSTQAGGGKRPQ*
+
+>NODE_4#PROKKA_00218
+MKAGMVAPLDATQQSRLRVLLALFGLVWLINAGFQAVAWLAAPNASTHFIHALAKSTTVV
+PRWVQPLLMTGLHSAQSLGLGIVAAIMVLLAILLGLALLTQRKVAFAARVGIIYSIICWI
+FLDGFGFPYANGQTDPGVFVAYAIAFLFVLSVAPVFDREGTKAPEIDERLWHWARIAFGL
+LWLFDAVLKWIPPFLLHFSSQITSVIPGQPHWIAAWLSFVAELVHAIGPIPVAVVVALAE
+TAIAIGLLSGRWMRLVIPVGMLYSVAVWTTAEAFGGPYSTAGTGVRGNVLGNVLIYLIPF
+LFLWVGNSSQRSAAETTGRTLTD*
+
+>NODE_6#PROKKA_00240
+MGDPKGFMTVPRKEASYRPRNERIYDFGEVEQTLNEEDRKLQTSRCMDCGVPFCHWGCPV
+GSKIPEWQDAYYRGNEEVAYEILHSTNSFPEITGRICPAPCEKSCVLSINEEPVTIRENE
+AANVENAFTQGWIKANPPSIRVV*
+
+>NODE_8#PROKKA_00287
+VYFRQYKVEGLGCYSYLIGCPAAGTACVVDPERHTGQYIQTAEHQGLRITHVFDTHLHAD
+HITGSAELAAATGATICVHPAIGAEYEHEDLLDGQHYRFGAAELEVVETFGHTPNSVSLA
+LTDHGRSEDVFALLTGDLLFVGDVGRPDLAGADLLEEQIHNLYESLYTKLGRFPDWTEVY
+PAHGEGSLCGKGMSAKPMTTLGFERLNNPLLADLEFAEFHRIMTEAFQVRPDNFAAIVAK
+NQRGPQLLREAPAFMELSVLQAERALAAGAQIVDTRAQSAFGAAFLPGSLNIGVSPSSVN
+WLGMLVPADTDIIIVADSKDVACQVADQFRRAGYDRLIGYVPDGVASWALQGKPMDHLPQ
+LTPASLKHVVGRYGNHVILDVRTDAEWATGHIEGAIHLPLPRLVREGIDLGKDRHITTVC
+RSGYRSNVAGSFLKSQGYEHVFSLIGGMTAWQAANR*
+
+>NODE_9#PROKKA_00320
+MPTATIRQQLIELLSENKYDARDLSQRLGVRETVVYDSIPHITRSVTSMGKKLKIVPSRC
+TSCGYTFKDRKRAAKPSRCPTCKSERIAKPKFYIV*
+
+>NODE_8#PROKKA_00300
+MTQGLGPGLVSPAPFGAEEKPRGGLGEMGAFYAKGVTYWRSVTTP*
+
+>NODE_2#PROKKA_00112
+MDWIIVIILAILLVAFIILFLLIQKGFRNPVSEHTIPEDLPFDVQEVEYPTKNGKTIYGW
+WIPADPKAATVVFVHGWGRNAQRMMPYLRKFCCGKFNLLAFDARGHGNSDHDGFSNMLQF
+SEDIIASMNFIEQEHKAENNMFYLIGLSIGGAASIYAAGHDPRVKKVLTVGAFAHPASVI
+TKQIKDRHIPYFPMIWFLYRYMKYVKNLDVDAIAPEKHIAKAQAHFLLVHGEIDQTVPVE
+QGKRLKKAAGDKADLWLMPERGHSDCHLEHGFWEKLMEFFEAPKTKVQKS*
+
+>NODE_11#PROKKA_00013
+MTAPRWSATRASASSQSSRAPPGRERCSCRRPSSRRRRAGSSSRARPREPPLMAALRRAS
+WGSSPRRVSSSTTSSGSRGEKFTRRQRLTRVGSTSRGSCTVSTRMLLGGGSSRVLSRAPE
+LARLSRPASRITTMRQPPPKGAKLSVRITSRTCSTLIWAEGESEGGSTTKKSSWLPAARR
+RQGPQAPQGVSPGSWQLAAANRARAVVVRPTPRGPTKR*
+
+>NODE_5#PROKKA_00235
+MPAKIPDPVELTRRLVAFETINPPGQEQACAAFLADLLAGAGFDCVLHPLGDDRASLVAR
+RGRPTEQRLPLAFTGHIDTVPLGAVPWKHDPFAGEIVDGRLYGRGSSDMKSGVAAFVVAA
+IAEAERIGDGAGVELVITAGEETGCDGARALADGGHLGRAGALVVAEPTANRICVGHKGA
+LWLKAITHGVTAHGSMPEHGDNAVYKAARAIGRLADFDFNVARHPVLGRPTLNVGTVSGG
+LNVNSVPDRATVGIDIRTIPGMDHAPLRDGLGGVIGEGADLETLCDLPGIWTEPELPWVQ
+RAAAAVAAVTEQPFAPESVAYFTDASVITPAYGDIQTLVLGPGEPSMAHQTDEYCEVERI
+VEATDIYRRLIADWMKPES*
+
+>NODE_8#PROKKA_00290
+LSDSSRTSSARNEPGETVLAGTGVSPGTVIGKAVVVGASVVSVREHELPVSQLEDEVGRF
+RAALEKSRRELEELRDRARDEKNQDLVDILEMQVMVIEDGMLDQEVSDRIRDTRRNSGFV
+LKNYVDEFCDQLVKAGSAFFAERTNDIQDLAGRILRQLLGSESVDLSELPEPCIIIAHDL
+SPSDTAGMDRDNVLAFVTAMGSRTSHTAIMARALGIPAVVGLGESLAQVGDGVRLVVDGT
+QGRVVVSPENATLVKYHERIEQEKAWRAKLEVNALLPAETRDGFHVSVAANVELPEEVER
+IRRVHRVGIGLFRTEFLFVKGGSISDEEQQYAAYRRVAEDVAPHSVVFRTLDIGGDKFLS
+HLDVPVEINPFLGMRAIRFCLRREDVFRSQLRAILRASAHGGVRILFPMITTMEELHATL
+AILDDVKAELERQGIPHNPDLDVGIMIEVPAAALIADKLAPHVDFFSIGTNDLVQYMMAV
+DRSNPDISYLYQPGHPSVVRLLDRVVRAANEHGRWVGICGEMAAEPLFVPLVLGLGIHEL
+SMSPVAIPIVKDLVRDINMLEAEELVDQAMACGSAEEVTQLCRSFVERIAPELFLD*
+
+>NODE_3#PROKKA_00157
+MQTLNIPSLATVTAITLLTTACANNPTPETLQSRGLHPLDTTQLHQLYSKTLQFDWRNAR
+SRSGSGEYQPNGEISIEWSGESFNGKWRILNNHFCATYASIHNGQEQCYMVYQTGARRYV
+AFLNGDYSYSFNVKKVK*
+
+>NODE_7#PROKKA_00272
+VCEGLGFESGVDKKFSEAPFFYWLYTLLIVGGAAVVLIPHFPIIEFSIFSQMLNGILLPI
+VVVFMLLLINRKDLMGEYTNSRWFNAVAWVTAVVVTVLSVVLMVQSIRQV*
+
+>NODE_25#PROKKA_00103
+LNRSLQNQISARYWSSHISSRNNIQNNENCACDPRLAPCLLVCRASLIPFLPFLEGAKLK
+KLGAFYLGRRRRLQAGKHAGSSRHQSGPGAPRRFLFGGNCDPPWRATHPPPRRQGRPAGR
+PLSTMQNKPGKGITLLSSRPPAVPPRRGRSPAAPPSPWRPAWP*
+
+>NODE_9#PROKKA_00316
+MAKADESDRTQLEALFSIGAGVRSLDELLTRRLIFLMGKGGVGKTTLSVALALTAEMMGK
+RVLLTEIGDSQGIGRYFDAQPDVRPRQVSSAIWAARVDPKDELTAYLHYHMKSGFIANRI
+TQSRLFDYLLAATPGLKEIMTLARIWRWEKAKNKAGTPLYDTIIVDAPATGHGLSLLRLP
+KMLVEMIRVGPIASQVNGVQQMLLNPERTALTLVTLPEELPVNETREMIDIAVDEVGIPV
+QAVFINGVHPVFVTPDEFSRIQELDRDCPDADPDCPDLRFALDVARRQIVRNAAQQVQMN
+EVHAAAPGHVIHVPYYYTNDLGPEEIRTIAASLHRQISEAPRGGGR*
+
+>NODE_3#PROKKA_00166
+VDESREKSGRRGAGVAENPTRELLDAYASHHRKIARDSLIRLLRNPIGSLMTWLVMGVAL
+ALPLGLMLLLASAQSLGEGWSDSSRINLYLKQNVDETAAMNLQGKLRSRGDVRDVQLVTR
+KQALAQLRKDSGLSAAFDYLNDNPLPNTLIVAPALQDPGAVQSLSQSLKQLPQVAEVQVD
+LAWLKRLRAMIGLVVNAVWALGVLLALAVLLVVGNTIRLAIENRRDEIVVAKLVGGTDAF
+VRRPFLYTGAWYGLGGSIVAIILVALFEAWLDGPVNRLASLYGSHFQLQGAGFGDFLLVI
+MVGVLLGWMGSWLAVKRHLDAIEPR*
+
+>NODE_7#PROKKA_00279
+VYESRPQTTPEQHSSSIEGSHPTDAAAAAGSRSVELAQTDFLLRLTDALNTTLNLQTLLQ
+RTADLVRTVIDYRIFAILLLDNRTNDLRMRFQTGHRPEVERMRIRLGQGVTGQVALTRKP
+MLIPDVRDVENYINANPDVHSEIAIPLIVKNRVIGVIDIQSEQPNYFQPDHLHLLTLTAS
+RIAHAIDNARLYTRVSRQAQTLEVLNEISRDLSSILDTDRLFERISQLLRRLFDYQMFTI
+WTVRPIEHVLENRFALRFGERYYPNETIPVERGIVGAAIAERRPMNIPDVRRDPRYHKVN
+EETRSELAVPLMYKSKVVGVLDVEHTQPHYFSEDHVRALTTLAAQIAIAIENAQLYQRVI
+QQEQRLDHDLQMAREVQLRLLPPSLPSRPHAEFAARFLPARTIGGDLYDYLNYDDQRGAL
+AIGDVSGKGAAAALYGAVVSGTMRSQASLKPSPAAMLQALNASLHERRLDSQYVAMLYTV
+WNDENLTLQIANAGSVQPIYCRSGEIETVPVEGFPLGMFPQAEYEEISLSMRPGDSVFFF
+SDGITDGENEAGESFEERLTDSIARHHHLPAEEAVNAVFEELQEFQGDCDRFDDETLIAL
+RVV*
+
+>NODE_9#PROKKA_00304
+MTTPDINFTDLLQFLFMGIQRGSIYAMVAMGVV*
+
+>NODE_10#PROKKA_00004
+VAEVLRVKELVKHFPVRQGFFGRRQGVVHAVDGVSFTLEENQTLGLVGESGCGKSTIAFC
+LLRLIDPTAGEVWFQGRNLAAAGSEELRRLRRDIQIVFQDPFGSLNPRMTVAQIVEEPLL
+NHLELSAARRRELVAEGLSMVGLLPEHAQRFPHEFSGGQRQRICLARALVLRPKVIICDE
+PVSALDVSVQAQVLNLLSRLQRQLGLSYIFVSHDLAVIRYVSQRVAVMYLGRIVEQAGVK
+ELYARPMHPYTQALLSAVPVPNPRRRRRRIILEGDVPSPLDPPSGCHFHPRCGRAMEICR
+HQAPELRPLADGHLVACHLYDEVRSAPGGTVEGG*
+
+>NODE_2#PROKKA_00146
+VVLLLSLAIIIAFRKFSSNIHFLENIGGVLGTVVSASFLTLIGIINFFILKNLYRMFKLY
+KKGEGAEKRIEEITENLLNKRGLLNRFFRFAYRSIDKSFKMYPLGFLFGLGFDTATEVAI
+LGISATVAKDSQLPIWGILAFPLLFAAGMSLMDSLDGLIMMRIYDWAMVDAVRKVFFNMV
+ITGTSVFVALAIGTIEWLQVVSIEAKESLSFFSFLNHLDFSVLGVGVVIIMLISWLSAFV
+YYRKVLS*
+
+>NODE_3#PROKKA_00192
+MARILIVDDSPTEVKKISSLLEKHNHEVLTADNGADGVAKARAESPDLVLMDVVMPGLNG
+FQATRQLTRSPDTADIPVVIVTTKDQETDRVWGTRQGAKGYLVKPVKEDELIKTIDDLLA
+*
+
+>NODE_5#PROKKA_00230
+MITIDQTLTPKDLTEDLARFWTLSGQKIRQLASRWNAGDGAPVFTVEGRYTSRGWTEWTE
+GFVYGSALLQFDATGEDWFLDYGRRGTREHMGGHVTHTGVHDHGFNCVSTYGNLRRLMDE
+GKLPENADERAFLDMALASSGAVQAARWTNLGHGKGYIHSFNGAHSLFVDTMRSLRSLAV
+AHMLGRDLKGEHDQSISLIERLAAHARTTAETAVFFGKGRDAYDEWGRTCHEAIFNVKDG
+HFRCPNSQQGYSPFTTWTRGQAWITLGYAEQLEFFRALEAAGRPEADDCSDLMGIMRDGA
+RATADHYIANTPTDGVCYWDTGAPGLAAMPDHKDRPADPFNEHEPVDSSASAIMAQGLLR
+LAAVLAEEGDDSAERYRQAGLTVARALLKAPYLSEADGHEGLLLHTIYHRPNGWDHIPAG
+RKVPCGESCQWGDYHVRELALMIGREAAGQEPYRFFNGLV*
+
+>NODE_2#PROKKA_00109
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_1#PROKKA_00092
+MKRAPVIPKHTLNTQPVEDTSLSTPAAPMVDSLIARVGVMARGNAITLPVCGRDVKFTLE
+VLRGDSVEKTSRVWSGNERDQELLTEDALDDLIPSFLLTGQQTPAFGRRVSGVIEIADGS
+RRRKAAALTESDYRVLVGELDDEQMAALSRLGNDYRPTSAYERGQRYASRLQNEFAGNIS
+ALADAENISRKIITRCINTAKLPKSVVALFSHPGELSARSGDALQKAFTDKEELLKQQAS
+NLHEQKKAGVIFEAEEVITLLTSVLKTSSASRTSLSSRHQFAPGATVLYKGDKMVLNLDR
+SRVPTECIEKIEAILKELEKPAP*
+
+>NODE_6#PROKKA_00247
+MIRYNLHQHSIFSDGAAEPEAYVQSALNLGFEAMGFSEHSPLPFPTKFSLKAERVEDYIR
+ETERLKEKYNDRIDLYRALEMDFIPGYSENFTEWRKKAQLDYAIGSVHMVQPEDDGELWF
+IDGPDRSIYDDGLQNFFGGDIKKAVKTYFHQVNRMVETQDFEVVGHVDKIKMHNQNRYFT
+EEEKWYRDLVEETLHLIKEKDFIVEVNTRGLYKKRSNRLFPDDYALQRISELGIPVLISS
+DAHKPEELNLLFETAEKRLLDMGLGAVVRFDHGKWKDFPLS*
+
+>NODE_39#PROKKA_00151
+MGKIVGIRFKKGGKVYDFDAGHFVLSVGDMVIVETEQGQALGEVVRPPVSHVLPELAPKN
+RCCEGCEDSGDEPAQLKQVYRLATEEDLRQLVENAKLEKEAFRYCQERIAARRMDMNLVK
+VECFFDRSKLMFYFTAEGRQDFRELVRDLVSRFRTRIEMRQIGVRHEAKLLGGLGSCGRE
+LCCATFLRDFEPVSVKMAKEQNLSLNPTKISGLCGRLMCCLTYEFETYKGLKQGMPKLGK
+RVSLNSGLEGKVIRQNVLKRQLTVILSDGREFTGTPEELEQLEPLAKPQAPPKPRGGQRQ
+QRNQQQGKGQQQTNSGGKSRSRNRRRKKKGS*
+
+>NODE_13#PROKKA_00034
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_2#PROKKA_00120
+MKIIKLAMFSKTQTMLQHKDINKLSELKNGFTQSWVEPDFIFRSLKCFSFSSLNKGLSPL
+KAKGYSFEWVMSLLISLPFMGISSVNRLAGVVEAKKDVFYRLKNNSSISWRYIQWLFACK
+FNTITSESTGNNIQPRCLIFDDTVIEKTGRFIEKVSRVWDHVQNRGVLGFKLLVMGYWDG
+TSFLPLDFSIHREVGKNKEYPYGLRKKDYRKQFKKKRSSQTHGYDRSKEAGQSKIDNMIK
+MFKRALSHGFSIDYVLVDSWFTCEAIIQAVTQVKNQTVHLIGMYKIARTLFEYQGTKQTY
+SQIRNRLGRPTRCRKLRLYYLQATVGFKGHQLQLFFTRQGKNGKWKVLLTTDCSIGFIRL
+VEIYQTRWTIEVFFKESKQLLGLGHCQSNDFDAHIADLTITMIQHMLLTLRYRYDTYESK
+GALFENVKETIAIRKLNERLWGLFVELLQILTDLFEIVDAMELLEHIITNGQALERLKLL
+FDLVPENNEAA*
+
+>NODE_2#PROKKA_00142
+MFSKIFINRPITAIVISLFIIIVGIISIFKLPVAQLPKVTPPVVSVSGHYTGANASDVEK
+AVATPVENSVNGATGMLYMNSTSANSGSFNLNVTFKIGTDVNVDAMEVQNRVNLATPILP
+AEIRQTGLSVKKASTSMLEIVGLYSPHGTHDEKFLSNYAALYIQNALSRVDGVGDVHVFG
+NSFAMRVWLNPQKMANLHLTTQDVINAVREQNAMIPAGSVGASPAPKGQTFQVTVQVKGR
+LVTAKEFGNIVVGTNPATGSVIRLKDIARVKLGSSSYAGTPRLNGKVGCGLAVYQTPGGN
+ALETADLVKAKMEQLSKNFPTDVAWTTMVDNTRFVQSSIDEVVKTLFEVLLLVIIVVFFF
+LQTWRPTLITMLAVPVSIIGTFAIFTLIGFTINTLTLFAMVLAIGIVVDDAIVVVEAVQH
+NIDRYGLTAKEAAIRAMSEVGGPVVAIALILTAVFIPVTFMPGITGMLYKQFAFTIAISV
+LLSAFVALTLTPALCSIMMRPNPVNENSKGLNRMFYKFNIWFDKTVENYGATVRKTIKHA
+PLMFILLGAIYIGTGLFSKYTSTSFLPNEDQGMVMAIAQLPPDASTQRTVKVLNQFGKIL
+NHNKNVKRYFLAPGFSVLQGAQMSNFGTAFIRLTNWSKRKGKNSSIQAVIGQLMGASSQI
+KGAKFMIIAPPPIRGLGRTNGFSFVLKQSTGSIQDLEKVQNKFLAALNKRPEIQMAYSTA
+TFNYPDIRVTIDRVKAKKMGVSLSALDNTIQTFLGGYYINDFTLFNRTFRVYAQADSSYR
+ANINDLSEYYVRNNQGNMVPVSALVNITRGTSAPVITHYNMDRNVNISGNAAPGYSSGDV
+IKVLRQVAQQVLPEGYSYEFSGTTLQEIEGGKTSTFIFILAIVFVFLFLSALYESFAVPF
+AVLLAVPIGIFGAYLSLHIGGLSSSIYAQIGIITLIGLAAKNAILIVEYCKMKYESGVPL
+VQAAVEAAKLRIRPILMTSLAFDLGVIPLMIATGAGANARINIGYTVFGGMLTATLLAIF
+FIPLFYVTIIKIRDRKKKPELVKTED*
+
+>NODE_1#PROKKA_00060
+MLVVIYALTTILTAFIGNNAAAVLVFPLAYAAATKLGQPFLPYAIAIAMAASASFTTPIA
+YQTNLMVYGPGGYRLSDFVRFGLPLNLIVGVISVVVIAWLWMP*
+
+>NODE_2#PROKKA_00136
+MDKEKKQKRYQRLYKQIQDLIVKSSNNPLSNMATINAVLYHKMETFFWCGFYLYQDGKLQ
+VGPYQGSLACINLAEGTGVCQAALTQQKTLTVPDVEAFPGHIACDSRSKSEIVIPVRNRE
+NELVGVLDVDSKEHNSFDEVDEAELEKIVRLVYFPEG*
+
+>NODE_1#PROKKA_00052
+MARIAGINIPPHKHTVIGLTAIYGIGRTRAAEICATAGVDPTRKVKDLSESELEAIRQAL
+TAYKLEGDLRRELNMNLKRLMDLGTFRGIRHRRGLPVRGQRTRTNARTRKGRVRRSAKR*
+
+>NODE_25#PROKKA_00100
+MRSIVIDELSSPDVDRLSEHLDQTLTPSGLSGVYWLELPEDLLLPLQQEHRQSCGPHRVA
+VVVEEGCLRLELLVRAQESLRCNCTAYASSAQRDFLLDYLDRLIEELGLRT*
+
+>NODE_4#PROKKA_00223
+MKTNRLFRWSITGIASVIPLALLAIFIFLLINSWPAIKFSGWHFLTGSQWSLGNEYGDLV
+TVNGQEVPPGADYGIGFLIAGTLLSSFLALLIALPISVAASAFLAEAVPKRLQNTLALFV
+ELLAGVPSVVFGLWGLVVLVPFMNHYIYPGLVHVLGDVPFFQPPTGAGYGLLTSSVVLAV
+MIAPLITSTVRGAIERVPMVQREAGLALGATRFEVLWKTVLPSVRRVVIGAGILALGRAL
+GETMAVLMVSGNALGYLPHNIYSPISTMAAFIVSQLDSALEDASGMATHALSEIALILFF
+ITLIVNVIARLLLWLARD*
+
+>NODE_2#PROKKA_00132
+MKTIDNYDFKGKKVIVRVDFNVPLNDQFEITDDTRIRATIPTIQKLRESGGAVILMAHLG
+RPKSGPEDKFSLRHVVKNLSEKLQTEVQFANDCIGDEAREKAAALKGGDVLLLENLRFYK
+EETAGDEAFAKKLADLADVYVNDAFGTAHRAHASTTIIAKFFPNDKMFGYLMENEVKSLD
+KVLHHAERPFTAILGGAKVSGKIEIINHLLDKVDNLLIGGGMMFTFIKGDGGKVGSSLVE
+DDLIETANAAREKADKLGVSLFIPKDAVTADKFANDANQKCRPSGEIPDGWMGLDIGVET
+SETFRQVIENSATILWNGPMGVFEMDAFAEGTVDVAQAIVRATEKGAFSLVGGGDSVAAI
+NKYNLQDKVSYVSTGGGAMLEYMEGKTLPGVAAIKDE*
+
+>NODE_11#PROKKA_00022
+VNYTDPQELLPVVDAQDRVIGTMTRQEIHAKGLLHRAAHVLLFDPAGRLYLQKRSAAKDT
+YPGKWTSSASGHVDPAESYAQCAARELAEELGLEAELRPLGRLPAGPRTENEFVEIFTGV
+SAEPPRPNPQEIETGRFFTPAQALKLAADPTRACPSLGAVLELWQELEGD*
+
+>NODE_9#PROKKA_00317
+MYQIKRYANGRFYDTVEKNYVTREQISKLLGAGKKISIIDTRTEKDITDDIVSRIKAKKQ
+NPSKSKKAGKSNKAVDDSTGMLVQLFRKGGDALFDYGKRYASMWQNMVTMSRDEVDKLVN
+MLVKDNKLTELEGSKLKKEIDRYRTNIQGWITRNIDNRVNEVLNRMNLANRDQILELTGK
+IEELNKRINRLGKEKKGPAKTKKTS*
+
+>NODE_4#PROKKA_00200
+VIAWVVLLALWLFVTRSRPGKAMLAASMSRTGLALVGYDIGKVYLQVWGLYGLLAGIAGV
+LLASFTGASASIAISLTVNAFIIVVLGGLGNVAGSLGAAYIIGLLGTLTAYLISPSVREI
+PGLLVLILILYVRPQGLFGRH*
+
+>NODE_2#PROKKA_00145
+MLLKKLNQNKFFSAFLAVSFLLSGFSVSLKAQGQKAVYQFNLNDCIHYALQNQASVKNKI
+LSEKISRENVKEAYSKLMPQVSAGAKYQYTIKRQVSFIQGNPVLFGVPHQLQGYLNVDQT
+LFDPSVLGSAKAAHLSENLSKENTQLSKIDVAANVKKAFYGVLVFREQLNLLNANIKRDT
+KSLADTKNQYKNGLAQKVDVDRIQVLVNNDVTARANASRNLNTLIQTLKYHMGMPIKDSL
+VIKGTISDAMLTEILPENNPMFYKNRVEFQQAQTTLAATKLLKSNVIRSYFPTLSAFYTL
+EAPYNSNTFPGLFKDKLYPTSFVGLQLSIPIFSGFNKHYQYQAAKMNIQISKNNISDLEN
+NIKLEYGNYFRQYKSDIANLKTQKENTKLAKLNYDNLKYQYDNGVQPLIEVLNAETTLLQ
+AQDNYINALYQALVDKVDLDKSLGKLKY*
+
+>NODE_42#PROKKA_00196
+MSKPKYPFEKRLEVVNHYFTTDDGYRIISARFGVPRTQVRTWVALYEKHGEKGLIPKPKG
+VSADPELRIKVVKAVIEQHMSLNQAAAHFMLAGSGSVARWLKVYEERGEAGLRALKIGTK
+RNIAISVDPEKAASALELSKDRRIEDLERQVRFLETRLMYLKKLKALAHPTKK*
+
+>NODE_12#PROKKA_00028
+MALLVSFFGKGRRGACLLGLLGLLLLAPPAVAAGAGYVVAPVNKGADLRLLPSEAWPPPE
+GSRADILIKLAYLRGIMDALQYLELAPRSAERVLNAYQGLSLQDLAARIDAFYLTDPRRR
+DLPPAVVLFRLLAPAGKDAPAVKGPARPGGQGGRSGK*
+
+>NODE_4#PROKKA_00207
+MRAPDELINGRWASEITAALPARIHQGVAQHWEADPEAEALVDHQVRWSYRELSAAVAAA
+RQWLVGQGVRPGDRLMLVSENGRALVALLLAASGLDAWAAIINARLADNEIDAIRDNCDP
+RLLIYTTEVSPDARNHAQRHDADIVHLDPLGEFAVGPAAAQSLPQPVVKDGTQVAAMIYT
+SGTTGQPKGVMLTHRAILFIARVSGGLRNLRPGRHVYGVLPSSHVFGLSSVMLGSLANGA
+CLHTVPRFEAGALLDALAGERISVLQGVPAMYARTLEYLHQHNRKLVAPALDYLSAGGAP
+LDTDLKTRVEATFGTTLHNGYGLTEASPTISQTRIGEDSEASSVGRILPGLDYEVVHLKS
+RQPVLQGEVGELRVRGPSIMRGYFRKPEATRAVLDDAGWLDTGDLARIDPDGQLHIVGRA
+KELIIRSGFNVYPPDVEAVLNEHPAVTLSAVVGRQITGNEEVVAYVQLAPGHDMTESALS
+EFAAARLSAYKRPSEIHILDQLPVTPAGKILKARLRALANQTPDR*
+
+>NODE_4#PROKKA_00214
+MHGLMMNRQLLISQILEYAAVNYPEQEIVSRTTEGPIHRYRYPELRDRSCQLAHALAGLG
+VTQDDRVATVAWNNYRHLEIYYAVSGMGAICHTINPRLPAEQFQFIVDHAQDQYLFVDLT
+FVPLLEKLHPQLNSIKGYIIMTDEAHMPETGLPNAHCYETLIKDQPTRYDWPEFDENQAS
+SLCYTSGTTGNPKGVLYSHRSTLLHAFSVMAFPGVDFGEESSLLPVVPMFHVNAWGMPYF
+ALITGSKLVFPGPRLDGASLAELINSEGVTDAWGVPTVWLGLLRHMNESGERFSKLEHVQ
+IGGSAAPRAMINEFQERYGVEAIQGWGMTEMSPVGSVSQPTPFMRERMSAEEQLTVRGKQ
+GRALFGVEMKIVDADGKALPRDGKARGELLVRGPAITSGYYRNDEANAKAFDDEGWFRTG
+DVATIDPDGYMEIVDRVKDVIKSGGEWISSIDLENEAVGHPEVAEAAVIGVRHSKWAERP
+LLVVVRNPDSAVTAEAIVEYLSERVPKWWLPNDVVFVDELPHSATGKLQKTKLRDDFKDH
+RFSDDEA*
+
+>NODE_4#PROKKA_00220
+MQRRYLATLLAGLMAVPAVAVADSGSSSSMPDMNIKLHAHLHGSVDFSNTGGRAVPNTEA
+YGEAAGTPARATNLSNNNSTIGFTGQHLVPGAFMAIFQVELALPGSETGVNNSYGKGNHV
+SKNVGLHDTYFGIANPLGTLLFQPSFENQGAYLSRPFNMFKDTVGDFNSIIDTANFPNGG
+PNGLPAISFAGQANYAISYASPKVKGFDAVLSYTEDANGGDFGTNNTYGSGYCAGTPNTN
+HYPNCYGYPNANQHNNAWSFGVQYENEFSSLQSKVNGLINYSQINVQGNTSGVPLGGFTF
+ADATQPNQTPPSSKLQLKALELAGKWDYEPTGTTAIAVWERSTGLYSRDAYSLGFSQAVP
+GNNDLMVSWIHAGNLSSPLANICDPTKTVCSGSEVKQSGANEYVAGIKHHFDKQVSAYLI
+YAYTRNNAEGLYGLGGPNHGQSVYPLNPGDNPQSLSLGMTWDF*
+
+>NODE_13#PROKKA_00041
+MRFKTLKYILVPVLAIGLSGCASTLTLLSPPSSRLVQGKNTAGAFNSYEYQYAVRGNKIY
+IKRTPLCDEVKHVMRVEQKREIGYGPALLELPLFGLGLVDIANAHAISVNSKKVTPLADY
+NTGKLMACGPLQPAANEKVIIENKNLNLYRMVRTDKNGVVNLDKVLSGIGNNVNLSVRLA
+NNHNVAFSCMYIANR*
+
+>NODE_1#PROKKA_00084
+MNLPANPRAQRRIDGLMAGQASLPGESGIDQTGRKMYAILGLDLDFSVWERLFQELLQVC
+PVHAIST*
+
+>NODE_8#PROKKA_00297
+MRWQRAMLFVAVLVACGGCSWRGKPRANHVRMYCLVDLEPVAEKLIQGFTESQGVRVDVR
+YIRPDELNKRLQRDEYVGLFLYANTWSGSAEENLLRARGNGGGRPAELGRFTPCLIVPKG
+NPKGIRSAFDLGKPGMVHGRTRQGACLLARISESGYRKPPKGPDTEPSNIRVRDTDYDVA
+RLVAGGSIDGAVVWSFTQSAMADEVEEVESKGLKRYGNVQHMVVGTPMSTPQPGLVKAFI
+EFATGPDGQAILRKTGLDVDPKCR*
+
+>NODE_7#PROKKA_00267
+MSENQVIIVSNRLPLSMTVKFGSLKVGRSSGGLVTALQPILKSRGGTWIGNGGTREDKRM
+ARALEEEARRSGFDCVPVFVTEQEDRNFYEGFSNQVLWPLFHDFIGECRFEPEYWDFYRK
+VNGKFADAVMRVYNGKQILWVHDYQLMHVAASLRERGCKGRVAFFLHTPFPSYDVFAKLP
+WRRHLLLAMLEYDLIGLQTERDVRNLVSCLRRLVPEASMSTDHGVHRVSWHGRTVVIQDF
+PISIDFDEFARAANQPAVEERMRTILARMGMGQVIFGVDRQDYTKGIPHRLRAYGELLRR
+RPEMVGKVKLVQIVVPSRQNIPGYEALKSRIEHLVASINGEYTQPGWVPIHYIHRAIPRE
+ELLALYRAAHVGLVTPLKDGMNLVAKEFCASRIDDRGVLVLSEFAGAAAEMYRGALLVNP
+FDLEGVADALEQALQMPGAQQQERMRKLRRFLKHANVHRWVEDFMEEIESVKAPRSRRG*
+
+>NODE_22#PROKKA_00097
+LHLDQDQQDFLRHIQQVVETQLAPLALEIESQSRFPQQAREIFARAGLFTLAVPRSYGGQ
+GADATRLALMVENIARVSPSAALLVFPSNAVLRTIALTGSEEQKERLFGELVQAGDQCLA
+FCLTEPDYGSEAFNLQTRAERQGDHYVVNGTKTFITLGPNARYYLTFVRTGPAPKAGGIS
+ALLIPHDAPGLGFGPPEKKMGLHGSVTTNMYMKDVPVPVANRLRGEGEGWQVLTRVCNPM
+RVWGAAAMALGTAQGLFDQTLAYVKANAERLNPADRQSRDFALADMKMRIEACRSLIYRV
+CRMVDDPRTPPQQVDAFVSMSKCYAADTGMETGELASRILGMDLMRPDCLAGRLYLDAKA
+IQIFDGTNQIQRLVVAKSLALG*
+
+>NODE_11#PROKKA_00017
+MEARTLFNGALGVKAHVRGLESVSDNIANVNTYGYKATRAQFSDLLYQEMAGGAGFPQQV
+GNGALTAVENMMMQAPLEPTENVLDMAINGRGFFTVKHPDRNEGNRYTRAGQFYLDKDYF
+LVNSEGYRVQGFAVDADGNVNVNQVQDIQIDNQIQDATATTSVDLAVNLDASDTTEFRQA
+VAIDPTDSGTYNFRMGFQVVDEDGDTQDIAVFYQKLESYTGDAPAGSQSVWKAATFHNDS
+GTLTADPSYPDNTFFLHFDTNGQLVGVTTGTPATGDSYTSNAEVSSTSASVSDRLGETFA
+YTGAGNTQTLRSTATITFSGTTTAGDTVTIGGTNYTFAALSPSDAAAWLADQINANSAGS
+YYAQDDASGTVTLYAKDGTAAAEVSASSVVISTDDTMSLTELVNTVDSGRKATGSLFVNI
+AGLTAGSSTVTVAGHTFTYGPAQDFTTLSELTTLINDLSEVDATSSGHNIYITAASVGTS
+GNSLGLATNDAANVAVSASTLLNGLDDSDATNIDASATTGSGGGQALKLDRTDVGASATI
+DVATTNTLGSNLGLDFTGGNFTQNSTASDGNGTSNTTGEVPLTFTFTKSGSTLTQQVTLD
+YSPTDGDDSTMLAGDYETFYLKTDGRGTGYLKYLEIDDQGLITAHYTNGQGVPQAALALT
+TFIAPQELLREGDNLWRATAAAGVPTVAQAGDAQTAMGEVKSYALELSTVDLAQEFVNLI
+NYQRSFQANSKSIITGDEMLKTAINLKG*
+
+>NODE_4#PROKKA_00203
+MFCNGNQGYDFSINSHPGHAHQMQRRSHATNSQSGPVP*
+
+>NODE_1#PROKKA_00068
+MIKVGINGYGRIGRNVMRALYESGRRDQLQVVAINDLGDAQTNAHLTRYDSVHGRFPGDV
+QVEQGHLVLNGDVIQVLAERDPSKLPWGKLGVDLVLECTGLFTSREKASLHLQGGAKKVL
+LSAPAKDDVDATIVYGVNHKTLEPEKHVIVSNASCTTNCLAPIAQVMHELAGIEGGIMNT
+VHAFTNDQNLLDVYHKDLRRARAATASMIPTSTGAAKAIGLVLPELDGKLDGFAIRVPTQ
+NVSFVDLTLNLTREVKVEDINRAMREAADGRLKGVLAYNEVPLVSIDFNHNSHSSTYDAG
+FTKVKGRLVKVCSWYDNEWGFSNRMLDTAAVMFGRG*
+
+>NODE_3#PROKKA_00155
+MNKGTVLRVARPTDQLEKIAQMYMEGLGFERLGEFREHDGFDGVMLGLRSHAYHLEFTQC
+QHEKAGRAPTQDHLLAFYIPDAVEWVRTCEAMVKAGFVCKPSFNPYWDRLGKTFEDVDGY
+RVVIQKEQWLD*
+
+>NODE_3#PROKKA_00174
+MRPKLSHALAAILAACVMSLAPMTQAETTQSTPSALAMTGDALFARPALLAMTLVGSAVY
+VVSLPFSLLGGNASEAGKVLVVDPAKATFTRCLGCTMNQNRQNEQKNQNQVATADNTDTT
+SN*
+
+>NODE_1#PROKKA_00073
+MNATAPLQEQEPEPGNRRFPGLLMGGARQVARWSWQHRRYGRWPLRILLVLLLVLIILVG
+AGYGLLRGSLPQTEGTVRLPGLGGRVVVTRDAQGVPTIRAHNALDAWRVLGYLEAQDRFT
+QMDFMRRVAAGDLAALVGPAALPLDRIHARFDLRARAERIYLDAPSVERARLEAYTLGVN
+EGLDNLSVRPWAYLLLGERPRAWEPADSVLVIYAMGWMLQNPLGPRMRARAALRSLYPPA
+VTAFLGAPDTHWAAPMAGQPPALPPVPGTQLINLSASGKSRATAPVPSTAMYADTVAKLI
+LPQPFPGSNSFAVSGDLTGTGHALLANDPHLSLRVPATWYRARLIYPAPGATASQPVELT
+GVFLPGVPALVIGTNGHIAWGLTNSGGDWTALVRVKATAAGSRGGPLVYATPSGTATLAI
+QHVLLKVRGQTARPMSIRRTIWGPVIGTTADGALLVSHWALAQPGGVNLRFMQLDSQTTV
+KQALMVAGSAGIPVQNFLVADDQGHIGWTLAGRIPVRKAGCDYAVPQSWADGSCGWTGWL
+APGSYPSIVDPAQGYLATANNRVDARTAAVLALGDENFADGARAHQIVSDLKALAKRGKI
+TANDLHDVQLDDRAQFLQRWHDLLLNVLSPSALEFHPHRQALREAVVNWGARAAVDSVGY
+RMVRAFRNEVAASMFMPILKRLHTRDPGAGLPFSNQLEGPLWRLLQVRPHNWLNPAYPTW
+NALLVHAADAVIHRFWNPVSGLADATWGARNTVRINQPLAVALGPLGHWLDMPPTQLPGD
+SNMPRVQTPDFGASMRMVVSPQPSAPGLFELPGGESGHPLSPWYSDEFKAWAEGLLTPLA
+PGPARKTLRFIPWSRRVSDRPTVSTGSVVPAQSGQ*
+
+>NODE_6#PROKKA_00239
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_22#PROKKA_00096
+MDFELSEELKMLREMAADFAKEQIAPYADKWDEEHYLPHEEVIKPMGELGFFGTVIPEEY
+GGNEMGWLAAMILTEEIARASSSLRVQINMLELGCAFTIYRYSLHDEVKKKYIPKLVSGE
+WLGGFGITEPNAGSDVMGMKSTAVDKGDYWLLNGSKTWISNADIANCIIYYAYTDREARG
+KGLSAFVLDLKNEDGSRPEGISVTRLDKLGSHSSPTGEIYLDNVKVPKENILGKPGDGAK
+IVFSSLNQTRLSAAAGGVGLAQACLDESIKYANEREQFGKPIAKQQMIQDQIAQMAIEVE
+AARLLVYKAACQKDAGNLGNTLEVAMAKWKAGEVANFCAQQALRILGAYGYSTEYPVARF
+YRDAPTYFMVEGSANICKWIVALDALGLRKANR*
+
+>NODE_3#PROKKA_00184
+MKLLIQNGQLLDSRTGQVRSGAVLIEDQKIVAVGEQVLDQAADRVFDADGAWISPGFIDL
+CCFVREPGDDQKGTLASETRAAAHGGFTTVCASPESSPVNDSGAVTTLILERARKQGCVR
+VLPVGALTRGLQGELLSDMASLARAGCVALSNGSLSRGNARVLRRCMAYAKTFGLTLFMR
+PENPDLAADGYAHEGVVATRLGLPGIPEIAETIAVGELIQLAEDTGVRLHLSQLSAARSV
+ALLRSARERGVPVTADVAIQQLAFNEGWLADFDSRFHCRPPLRTEADRQGLLAAVNEGWI
+DAIVSQHQPHDPAAKQAPFGETEPGLSTVESLLGLGLKLVNAGELELPRFLQALTLGPAQ
+VLNLPEPRLEAGSRADLTLFNPNGQWIPAPETLLSAGKHAPVLDQPLPGRVMLTLSRGKV
+AYADPQTEFGL*
+
+>NODE_1#PROKKA_00057
+MRKVRVAIVGAGTAGLTALAQVRRRTDEFVIVNDGPYGTTCARVGCMPSKALIHIANDFH
+RRRRFAEVGIAEGETLRIDLSKALAWVRAYRDSRTADSIKLTDPLGERNIPGRAELLSAH
+ELHIRRADGGEERIAADAVILAPGSTPVIPKSWDGFSARILTTDTLFEQRDLPRRMAVLG
+LGAIGLEMGQALARLGLQVHGFELRDRLGALTDPQLIAPAIEHFSREFDLHLGAPAELHP
+TGEYWRVETADAQVEVDAVLAAFGRRPRLDGLGLERLGVPLDAKGLPPVDPHTQRVADLP
+IFLAGDANARSPIMHEASDDGYIAAVNALDGPTPLNRRVPLVMAFTDPEMAIVGASFESL
+PAGSFDAAGYDFSRQGRAIAMRHAEGRLRVYAERNSGRLLGAEIFAPEGEHLAHLLALAL
+DRGLNVAELLRMPIYHPVLEEGLRSALRALARRVYDQPPQEFRRLPEGCPGMSSSSP*
+
+>NODE_29#PROKKA_00106
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_4#PROKKA_00225
+MGTTFRPYSPDQELLLPPSLNEWLPEGHLAYFVSDVVEELDLSALYARYDGDGRRNSPFD
+PRMMLKVLIYAYATGTFSSRKIARKLEEDVAFRVLAAGNFPRHRTICDFRKQHLAAFKAV
+FIQVVRIAQEAELITLGTLAIDGTKVRANASKHKAMSYGRMQEEEKRLSKEVDELCRQAR
+RTDEEEDQQFGPDQRGDELPEELQHRQARLDKIRAAKEKLEADQKERDKARGRSPDDDRR
+SPRGGRNFKRDYGVPDDKDQSNFTDPQSRIMKTSDGFQQCYNGQLAVDGEFQLIVANHQG
+SNPSDNGCLLPLLNDVKDTLGTYPRQCLADAGYRKEGDLQTLEVNGIDGYVSLRREGRKP
+GEIDATRYPATARMAEKLATAAGRSVYGQRKHLVEAVNGWIKHVLGFRQFSLRGLNAVQG
+EWDLVCLSLNLRRMSTLMRMV*
+
+>NODE_13#PROKKA_00037
+MNDPIYQKLATVLDTLPNGFPATEDGKEIRLLKKIFSPEEAELFCDLKLTFETAEQIANR
+TARPVEELKARLSVMQEKGQIFGIDMGGVGIYKMLPWAFGIYEFQLPHMDRELAELCEQY
+GKTYGKQFFANKPQLMQVVPIESEIKAEHEALPYERVSTIIENSRSFMYFDCICKKEKGL
+MDEPCDKPVQVCTAFAPIPGVFDDHPYGKTMTKEEAYQLLNKAEEAGLVHLTWNVKSGHF
+FICNCCGCCCGVLRGINELGIDASKVINSYYYAQIDAEACVACGTCADERCQVNAIMEGD
+DAYTVIAEKCIGCGLCITTCPGDAISLVRKPAAQIETPPDDEMDWYEKRAQLRGVDISDY
+K*
+
+>NODE_3#PROKKA_00162
+MFGITATEAQSEYEPTEEPQGETKLRVLVIEDDQDVAAYLIKGLKESDYVVDHAADGKTG
+LLMAAGEDYDMMIVDRMLPGMDGLNIIKTVRATGNTTPVLILSALGDVDDRVEGLRGGGD
+DYLTKPFSFTELLARMEVLVRRTRSSNEPETVLKVADLEMDLLARTVKRAGQSIDVQPRE
+FRLLEYLMRHAGQVVTRTMLLEKVWDYHFDPQTNVIDVHISRLRAKIDKGFEKPLLQTVR
+GAGYMLREDT*
+
+>NODE_3#PROKKA_00177
+MTGQDQLQRFLFENSNIRGSIVRLDDTFQQATGQQDYPTVVRNLVGQSLAACALMGDSLK
+FQGSLSLQAQGEGPLRLLVSDSTDQLTLRGLAHWNPEAAEAETLPALIGNGHLVITITPD
+AGQRYQGIVPLEQDTLAGCLEDYFRLSEQLATFMCLFADEKGAAGLLLQQLPGELAGPDT
+DLWPRAIKLAQTLTTEEALQLPSEELIHRLYHQEQVRLFPARATRFGCSCSRERTRLALE
+SLGQDDCMALLDEQEVIEIDCHFCGQRYRYDRADVRAVFGGPRLH*
+
+>NODE_6#PROKKA_00243
+MLIQEASKWDIITYVLDNDETCPANSLATHFVKGSNLDFDSVYRFGKMVDLLTYEMENIN
+IEALKKLKSEGHQIIPDPDILELIQDKGKQKEFYQDNNVPTAPFKIYSSRQDIVQAIKNG
+EIKFPFVQKLRTGGYDGRGVAVISDENDLDKLLDGASIIEDKVNIAKEIAVIAARNKQGE
+IKCFPVVEMVFDPEANLVDKLICPSKITAEQSEKAIEIAGKIIGLLGMQGLLAVEFFVDE
+NGEVIVNESAPRPHNSGHHTIESIITSQFEQHLRAIFNLPLGSTRPKLPAVMVNILGGEG
+YEGPVRYEGLTEIMAIEGVKIHLYGKKITRPFRKMGHITVLSDSLETALEKAEKVKQLIK
+VKSWDKN*
+
+>NODE_5#PROKKA_00234
+VATLELIVERASGDVLKVELKPGTNVPAIHPGDKVQIVTPAGETLNAVVVGQDVQITPVD
+ASGTVGETIVFKNLALYLHDGQSEVAVVNADTGQTTEITDVASLADLGTVPLQMASGEGT
+GPVSPGTSSPFQNSDAIDHGGETAGNAAGTLGDILNRGAAGTDGGRAQLAGTGETGAGTG
+TGSSTTDHVETPISESTEGGGSGTGTGTGTTTSGHAVDGYIVGATVFADANANGVLDSGE
+ASTTTSYNGTFELSGSSGQLVMTGGVDQATGESFKGTLTAPAGSTVVTPLTTLIQSLVEA
+GQSAADAQAAVKSALGLTGNSIDLTTANPVEDVENGVSGADDVLAAAIKIQNTVVQAASV
+LQGAGGSTVAMSTATNAVFAQLATTLQNNPGSNPITDATAVQNLITGAANSSSLGLSSTA
+KTQVGNAASDAASVIDAGNSHINGLSSTGSSLLTDLASAARVAQNGAAEALHDALNAVQG
+TSNSANLSTATSSYTGANLTSEIGNASSGLGTVGTASSVGTSGDDTIQGTSGNDTLNGGA
+GNDTISGGTGNDILIGGAGNDTLKGEAGNDTLDGGAGDDSLYGGAGTDKALFDGNFSGYQ
+IATDSGSSGVITVTGSGTDTIDTTEVLKFKDLTVRMVGDSGGTANGYTSLSSALSAASVG
+ERILILDSATDPSTLTLSKKVSVQKIGEDPLISIASDGALVVDGSQLSAVTTLDLSSLPG
+TTTVRFTSLGSIASISTASTETLNLSASQLDGLTVSGSGKIQTSGIVATSADLSNLSSDL
+SVASGQSLELTAAQASGKTIAGAGNVTVNALGSSAVDLSGITASGTLTANVPSSATLNTN
+TDLGTFGVSVASGQTLTLSATLADGTTIGGDGNVTVTGLAAATDLSSVSASGTVTATVTS
+TVDISSNTHLGSVDAYQVTGALTLTAAQVGDSTISGSGNVTVSGLAATTDLSGIASSLSL
+TASVTSSIDISANTNLTTVDTYQVSSGQTLTLSAAQAAGHAISGGTVTISGNITANTDLT
+DISSTLSFDDGDSGAISVASGTKLTVTPSQAAALQTAGQTITGDGTVLIDGNVTADTNLT
+NISAAVDFNGNSVSVDSGHTLTLTATQASDTTISGAGAVALSGSDTNADLSSITADITVA
+SGQTLSLSTAQLATLDSNAIPIGGDGTVSLTGNATSALNSDLSTYLGSSLNLAVPSGESL
+SLTAIQANGLTMEVAGTANITGPAGTTAADFSNISFTGSGAATFTVGADLVISEANADFG
+SVSINIPAGRTLTIDAADASGVTISGDGTLAVTGTLDSSVNMSNWGTGAIDLTNVSASNF
+SLTQLDLNGSADYHLTYAQVQALSDGIDGNNSDNTLIIDVSTAGGVTYTNNAATIDLDIS
+LLGGADRVKFDFGGTTDSGNTLTIRGPLGFGDGSDTLESRHGTISLTDPGLTLSGGPEAL
+VANSGFSLTATLFDLLYGSSGVTLQGEGTYIVSIDAGFASGASPTLDLTVLDNFVPAGGV
+LPTLQIVATGYSVVGGDDGTGDGIATLSDGTHTITIKLPDDPDNAGTFNPGNTPVIIEID
+NGTSQFFLGGLDDQRAYYESETTVYTGSQFADLATAIATDASSLGINAGDIQTIKLGDSV
+ILDSDSAVDLSAFGGVIDYNGQTIQVTSGDSLTLTAAAADGGTISGAGSVTITDLGTTAV
+DFSGLTAASVTLAISSGTVDLSAISGLDLGNVGITVTTPGAVTLTAAQADGLSISGNGDV
+TLTGLGASEVDLSGLTATNATAEISADLTLSSLTNLGSLDLTLDDGVTLTLSRAQLDGRD
+ISLASGSATLAFGGNASGLDLSQIASGIAFEVVAGRTLTLSTAQINDGHTITGAGSLVVV
+LSGTEVDLASTAIQVTGTRTAVVSTSATLDGNTDLGDFSVSILSGQTLTLSTAQAAEHAI
+SGAGNVTVTGIGSTAVDLSTITVTGTKTVSLSADATLDPDTNLGNFAIDTAGHSLQLTVA
+QANGLSITGSGTAVVTGLGSDTVDLSGITATASTTVSDTVALAAGTNLGSVAVTVDGTGS
+LTLSASQADGHTISGTGAVTVTGLTAGIDLSSLASSLDVTATVPGTVDITGNTAQLATVD
+TYEVAGALTLSASQASGHTIEGSGSIVVSGLDGSAAYDLSGITASASTTVSGTVTLDSGS
+NLGTVAVSVTGSLTLAAAQATGHTLSGDGSVTVTGLAATTNLSGLASTLSLTAAVTGTVD
+ISSNTLLGTVDSYTVSQSTDALSLTAAQASGHAISGSGTVAISGLGAAVVDLSGIAATVD
+ATATLSGTEVILTAGTDLGTVALSVGSGQTLTLGAAQASGHAISGGGDVVVNGLSASTDL
+STVTVTGTVTATVSADLDISASSQLGSVDTFQVVAGKTLTLTATQANGQAVEGGGNVTVT
+GLAAATDLSGITATGTLTATVTADTDITANTHLGAVDSFQVASSTTLTLTADQADGQAVT
+GTGNVTITGLGTTAVDLSAIAATGTLSAAISGDITLAGDTNLGDVTLTVGAGNTLTLTAA
+QADGNTITGTGAVVITGDVAGYDLTHIAGTLDLTLPVTGDVLTLTDGETVHLTVAEANAY
+DSITGDGTIQLSGNATANFDHLTSILGDGVSLAVADGDTLYLTATQASGVTIGGIGTVDA
+SGTVTDGDFSGISADLNLTDATLDGTTTLPTVGAGHTLSMTSDQINAASIALADSTATLH
+VAVSFDALSSSNDALPEIDISEIRVDGSNSPEAVWNSVDVASGSIVDKFKLFWISADKQY
+YDSTPLGQDVDANRAFVELGNLYAAYLAGADGELGTADDGTPILDVVQTKSGGVADYDAR
+QQSLHDNLLGNLSDGAIAGRFGTDDPRSDLAKLFGDRPYLAGSVDGNGLYTNDDSVAAVV
+GWDLYHGLDYTASLSGGYAVLDGDNSVTGTSGSDYIYAGGGDDTVSGGDGADVLYGGSGD
+DTLNGGAGDDTLYGGSGDDTLTGGAGADTLSGGDGTDTASYAASTEGVTVDLETGVGTGG
+DAEGDTLSGIENVTGSAEADALSGDANANVLDGGAGDDTLTGGAGDDTLSGGDGTDTAVY
+TAALTTDNITFDTDHWVVATDGAEGTDQLSGIEVIDHGGSGNILLVGGDGFASIQDAIDV
+ASDGDTIMVAPGTYAESLTIDKSLTLIGDPATGDAGAGTSAPQILGSTDWTLATVSIEAE
+NVTFSGFDVTNDTGPYGIHIKAGDADVSDNYVHDINGALSGDGIRAIFINPVDNVTVSNN
+IVEDFGNADNPSAASYTKTAAGIYYWARGGTLPGGTADIAELHNVTIENNVIHNDGLPTF
+TGTSVLGIWVGSSQGGSVLDTVSIAGNQISDLHTDNADRLTGGILVNHGSNPDGVDPLAS
+LDTPGVTTGLEISGNTIDDVSGASVFAVGLRGQTPDASVIDNVISNLALASGSSDGLLAS
+ISFQYNTTTHSVSLSGNDLGGYDLLQVGHDTSDDTLTPATADDTLTAIDGYDNILVGQSG
+DDTLTGGDGNDTLLGGNGTDTLTGGGGTDTLDGGDGTDTAIFTGTRADYTIAVDTDGHLT
+VTDTGGTDGTDSVSNVETLEFTDTSVSVLTVTETGANGTYSSIQAAIDAAADGDIIYVAD
+GTYTQTGTLNVDKAVTLIGQSEAGVVIDASAVHGYGILLTADGATLSDFTLNGPQGGDET
+VWSSYRVDYGIKVSPNGTASSLSDITLQNLTVSGSHNTEIDFNGIHDSTLSNITVDGGTG
+VAGNGISLTDSSNITVNDVTAANNPWGGVAIYTDGTHYAGGSDGVTFTGDYTYDAGSTGA
+SPIYIQATGNTYPVTNLTLPDGYDFAVTNSEYRADGNEFTFFFTSESDATAFGNSLGAGS
+FVSTPDADTLTGTANADYLYGGGGDDHLSGAAGDDRLVGGSGNDTLDGGDGMDTAAVEGN
+RADFTFTDDGSGHLVMSDTQGTNGTDTVSGVETLSFTDGNVLVVGAGSEYATIQSAIDAA
+ASGDTIVIAGGTYAESLSLDKALTLQAVSGADVVIDPASGNGLTVSGDLAGGDVTVSGLT
+FTDGTMGIQVAANADVGTLTLDGVTVEDNLQYGLRTDSGSMAAVIVTDSTFGDNGTQNVN
+GSAQMKLYNFDGDATFTRVDLVGAPAGTDQNSRPDYGIELTGLSNTGLAEGGTSPDLGTV
+VFTDVTVSGEFHKIGVAVYNYGQIDGLDIQSLDLSGTETNWGPVFNIDGVEDSTVDARNY
+NITYPAGDAIVAELQGEVPDQTATDTTIYGTDANERLMGKAGDNVLHGGGGNDELYGADK
+PGNPAEDDSGNDKLYGEAGDDLLAGGAGADILDGGDGIDTASYARAGATEGVAVDLANGT
+ASGGDAQGDVLSNIENLVGSSYDDTLTGDGNDNVLTGGAGADALDGGDGSDTVSYAGSSA
+AVNVDLATNTVSGGDAEGDILSNFENVTGSSHDDTLSGTSGDNVLVGGEGNDTVVYTTTV
+AASDVSFDTDHWVVTTASAGTDQLSGIETIEHGGGSNILLVGGGGYATIQAAIEAAGAGD
+TILVAPGTYAPFATSFGGPANITVQAMGDPGDVIIDATGGAPSNGRILDLRADGMTLDGF
+TIEGPGHAGVGISINGQGITVENNVISNVLTGIQTGTQYDTGNVTITGNTVDADYGISLQ
+NTANTVTDNTVHATTEGLGVLDVAATLSGNSFTVDAGGEGLALYGGATSSTFTTSGNTVT
+VGEGANLQHATDLAGTDGTLNIGAGTYEQVISIAKDGLTVNGSDATLVVDGSSSDVNGIA
+RVDAVTIYGDNVTLQGLTIVDSLVDQSYVTYGWPETTRGIVVKNGAENFTLTGNTIESTR
+NGILINGIDNTGSVTDNVIDNTKSGISVQYTDASGIIIAGNQEGTYGNEWGLNLHLNGYW
+DGTTYTSNNADNYPILGTAPTADWQASLLGLSTGNDGWAVMDQAYALYNRTLVTVDPDGS
+PSSFSNQGSQRSPISTIQNGVDLVVAGGTVHAHAGDYSGESVTVHVDNLILDGDAGATGI
+TVQLADGLSNLTLAGEADYTATGNAADNTLIGGAGDDVLTGGGGADTLTGGDGSDTASYA
+ASAAAVDVDLGSGTASGGDAAGDTLTSIENVIGSAYDDMLTGDAGDNVLQGGAGADSLIG
+GAGSDTASYADSSAAVDIDLAAGTIAGGDAVGDTYSGIENLTGSAYADSLTGDSGDNVLT
+GGAGNDTLTGGAGNDTIDGGAGTDTAVLSGNRATYTLGVNADGNITLSGEGTDVVKNVET
+LQFADDSASILVVDPGTSGAYATIQAAVTAASAGDIILITGGTYTENVTLDKQVTLLGAQ
+AGVDADGRTGVTESVIEGNITVSGAADNATIDGLTIHNGASVGGDLAGVYLASGATGTEI
+TNTIFTRDGTVDGDSSRGILTTYNGGNTDVTIAHNSFSGWATGTYVNPGSQDIQITDNQF
+DGNYVGLSVDGPNGAVVTGNSFTGNQFEGLGIGPGTGISGITLSNNSFADNASQVGVYTD
+AIDVNALSGNTFDGAVVISGSDTVYASIQDAVDASSDGDTILVYPGEYSELANYNPTTGE
+NSGTGNPLGLLINKSVTIQGVTADGTYITDAGDVAATVTSGAQSNWGTNFFVTADDVSIN
+GLDLVATGSTGQPYVNKSIEVVGDGFTLNHSVLGAADGLPMYTAVYVNDWSVDSGFTASA
+IASYAVLNSQLYGDMVVTNGPGTGYTADQLDMRIVGNSFLTIDGGIPNDGILVTGNDDNI
+AWRNASAALPTEISGNDFGDASGVLWVRGDGTQDFPTTAEVNGILADNSVPAYAYAVDGN
+GDLAAGTYGSSSIPSLAIRATAADFAPSELSGAGAESLMVQQAGETTPHSYSLIVGADGV
+ADSLTGTSGDEALIGGSGDDSLSGGGGNDILVGGDGNDTLTVGDGSAVVYGGDGTDTTAY
+STTVSADDISFDTDHWVVNTSSGTDQLTGVEAIDTGGSNKILLVGGDSGYATIMEAVDAA
+SAGDTILVAPGTYEPFSMGYWSPSDLTIQGMPGAVIDATSISTPARIVDLTAEGTTFSGF
+TIVGPGDVDDAGISVGISISAQGVTVSDNTISDITTGIQNHTPADQTGASSILDNTISGA
+NVGISLQNVNNTVSGNTVTTVEAHTLGVGEVALGVLGGDNTITHNTFTVSNSGKAIGLPD
+LPAVANLTTSENVVTVGEGADLQNAADLAGTNGTLHVGAGTYAQELTITTDGLTVTGDDG
+ATIQVADPGVYSPSSDAFAARTIAFTIAATGVSVSGFEINGPLSAYTYTTTDFATLGYTY
+GFFINDGVQNTTLHDITIQDIRTGMSFEGDNTATVYDNVIDNTRGAFLVRSDGVDLHDNS
+FGSTGNEWDLTMLAGTPSDYFGDPLTDPGTYGDNMMALSAANNDMTIADRMYGEGGVLAR
+AASDPDLADQYAAVANRSHVEVLAGADNDTSAGLGETRGNGFGTERLPVGTLQDGVNAVV
+QGGSVHVQGGDYSGESVTVHSDNITINGEASAIGIDVHLGIGLSAITLEGSADFTATGND
+LDNTITAGAGDDILSGGDGADILFGGDGNNTLTGGDGADKFMISAHTDGSKDTITDFGQG
+DSLDFHDVLSDPTDVVFTDDGSGNTQITTNAAPTIVLAVVEHVEPASLTVDDHGNVTLAQ
+TS*
+
+>NODE_3#PROKKA_00152
+LHACRSTLEDPTRKQPRNTSTAKAYLDEHFQHKLTLETLAGVAHLSVRQLNELFRRQIGM
+TPHHYLTEVRMQQAWQLLEGTDLSVQAVAERVGYSSLAAFSDRFHQHFGHPPSHFRRTGK
+TLRQNR*
+
+>NODE_4#PROKKA_00221
+MFDRHHQVWPEFAPLHLTLPETSICYNLEVTAHRYPHKDAIIFYDRRISYGEFQRQVEIL
+AGFLAREMGVEKGDRVLLYMQNSPQWMIAYYAILRANAVVVPVNPMNRRGELEHYASDTQ
+ARVILCAQELFDQVSPLLGEEGLSRAVVAAYSEYLPDQTDLPLPDAVSEPARAINQSGVV
+PWRQALAGEPAAPKALVGPEDHCVFPYTSGTTGAPKGCIHTHQSVMATLVGAVAWNPATA
+DSVTLVSLPLFHVTGMQVSMNAPIFVGATMVIMTRWDRRVAGALIERYGVTEWRNIVTMV
+IDFLSDPEARNYDLSSLRAIGGGGAAMPKAIAERLHEMTGLTYIEGYGLSETIAATHVNP
+VDNPRAQCLGIPVFDVDCRVLDVASGQQQDVGEVGEIVINGPQVFKGYWNRPQATAEAFT
+EVDGKSFFRTGDLGYYDEQGYFYLVDRVKRMINASGYKVWPAEVESMMYQHPAIRESCVI
+SAPDERRGETVKAVVVLTDDAPADVTEAAIQQWCQDNMAAYKVPRIIEFRDSLPRSATGK
+IQWRVLQEEERERAAG*
+
+>NODE_12#PROKKA_00032
+VARLSEDERRIRRMVGSRIRELRQALDLRATELASRAGISQSQLSKLENGKAAISIPVLT
+SLCRVLDRPLSYLFQKEEEIPRVLGTMTTVSGPENRGLEWFAAEVNRRSGGRMSIIPLWA
+TMLGSAPDQVAMLRQGVIDLFIEELIFYQHIAPAVKLISLPYVFADDAHLLSFLESPFFQ
+ERVHGPLTKSGIRILNRRWNWRRGLERVLVARQPVTRPEEVKGLKVRIFDSPALARFWEE
+LGARPVVVPWPRVREAWEAGEFDLLPTHRSHLYPLGFCRQGRFVTLLGDVPPALAVTVNE
+QKYLSLPPAVQAALEESCDAAGGFFSIEIRRAEVDNQAANLAEYGAVYLKVDLEPWRRAA
+GRVVERMAREGAVDLDAWQAVQELRPAGEGA*
+
+>NODE_10#PROKKA_00010
+VEVDISLFSNQNQFVILRVGEQAYALPAAQVREMQVLPEVTEVPRAPAHLRGIISPRGEV
+LPLFDLRRRLGMRSLAEEADELLKILEAREQEHKQWLEELESCIREEREFTLPTDPEKCA
+FGQWYQNFTTEDLALASVLERLAAPHRRVHEVAGAALEALEKEGQAAAQEVIDRARRIIL
+PKLLELFAELKRLIRETHQEIAVILESGRHTLALAVDNVDSVELLQPKDLQNLERFGPVD
+GSQDLLESVGRRANGETVYILKTAEFFQAATDLTF*
+
+>NODE_10#PROKKA_00008
+MPLGKGRGGALPWDPRAEAALGRVPFFVRSLVRRKVEERVAEAGGRRVGLEDFQEAEAAF
+RAVRAGKSQKELEAMLPAENRPGVEMVVVQACRSRLSNCPNPLIDTQKWLERVQAWVEEL
+DLSERLRRRVADDKILFHHKLKIAIAGCPNGCSRPQIADLALVGMTRPRLVEPEVCTACG
+ACAEACPDGAVSQDDGPPEFHRELCQGCLSCSRACPVGGIELDPPGVRVLMAGKLGRHPH
+LARPVMEATGPEPVLAYWTRELEEYLASAPPGRRFSAWWLEQHPAG*
+
+>NODE_3#PROKKA_00183
+MSFLIFVALLVALWLLWTISRNTADALDKQTAVQYEIIALEKRMEELSEALKAQSGETAK
+PARRSSSSRSKKEDEKEKKEGE*
+
+>NODE_6#PROKKA_00249
+MNTVSLSGSLRENVGKKDAKKQRRLGKVPCVIYGGSEQKHFTLDQLEFKPLVFTPEASVV
+NLTLGEKTYECILQDVQYHPVTDEILHADFLEIHSEKPVNIALPVELTGTAPGVVKGGKL
+RLKMRKLRVNGIIKLMPEHIVLDISKLDIGRSIKVRDINQANLTFLDPGNQVVVAVVAAR
+GLSAEEEAEEAEEGEEGEAAEGGEEGGEKSAE*
+
+>NODE_2#PROKKA_00113
+MKKFHLLLLSLLSGLLLAAAWPLHGFTPLIFIALVPLFFVQQQMGDTGKRGMLLYAWLTF
+LVWNGLTTWWIWNATPVGAIVAIVLDSLFLAIVFQVFHLSKKWLFNNKQGFFILIFYWIA
+WEHFNANWDLSWPWLTLGNVFASKHLWIQWYEYTGVLGGSLWILSVNILIYNIIKSFLEK
+RKQRALYTTILTVLFIAVPIIISLNIYHHYKETKNPVNVVVVQPNTDPYTEEFNLPPSAL
+IKRNLKLAEQKVTDSTDYVVFPESTIQEQIWEGSLNRSQSIKTLRNYVMEHPNLSMVIGA
+STFRWLKPGEHRTNAARFYKKGLYYYAYNTAFFIDHSPYIQVHHKSKLVPGVEKMPSWPI
+LKPLEHLALNLGGTVGTLKEDDHVSLFTNDSSGTKIAPMICYESVYGDYVRQYVAHGAEL
+IFVITNDGWWGNTPGYRQHFSFAILRSIETRRDVAQSSTTGYSGFVNQRGDVLQRTKYDE
+KAALSQTLNLNDKLTYFMKKGDYLAHLAGFFSILILLAAIVQGFLKKRNLPH*
+
+>NODE_4#PROKKA_00212
+MVERKHGGLIVAEHLQAAGISHLFALCGGHISPILVQAKALGIEVVDVRHEASAVFAADA
+MARLTGRPGVAAVTAGPGVTNTITALKNAQMAQSPVVVIGGATPTVLKNRGSLQDIDQLA
+LMKSLVKWQTSVGTLAQLDEAMRYALEVAAQGVPGPVFVEAPIDLLYPRDLVHSLYADQA
+GLDKMKGPVGRLLRGGLDLYLLRQERQPALSVHPNLKTLTEPAAEWHAARQLGEVVKRLA
+SAQRPALVLGSQVLVNRTAEQAKDIADAVERLGLPVWTGGMSRGLLGAEHDLLFRHHRGR
+ALAEADLVIVCGFPLDFRLKYGRGFAKGATLVSVNLSLHDLLLNRKPTVPVLAHPGDFLQ
+ALADRMSSRAAQWRAWLGELGKRENAREEEIDQQAAAPADKVNPLHFFRTLDRHLGEQDV
+LVVDGGDFVATGAYTLKPRGPLAWLDPGVYGTLGVGGGFTLGAAAARPGSRIWLIYGDGS
+SAYSLAEFDTYRRLGLAPIAIIGCDASWRQIAREQVEMLGDPVGTDLRDTDYHLVAEGYG
+GHGILVEHNHQIDAALAEAIKLSDAGTAVCINLRLAVSEFRKGSISM*
+
+>NODE_6#PROKKA_00253
+MHYNPNAFALSLRNSYSKIIGLIIPEITLYAFPSMIRGVSEFCYNAGYNVLILSSNESYK
+REVQNTELMLSSQVDGLLVAITKETRNHKHFDQLEKEGIPVVFFDRVFNNYGTSKVIIDD
+RRAAYEATEHLIKTGRKNIAYFGGNAALYITQQRLMGFRKALSDYNLEEHDLVFADDSHM
+ARNKALQIFKRKNYPDGIMSISDEVLTGIIPALQELNIKIPNEVGVISFSDGPISQMYKP
+AISIVHHSLARVGQVAVDLLIQRIEHPEDMHQQIHIIDTELIARGSTAIGK*
+
+>NODE_1#PROKKA_00078
+MNSSPRLQTGISQRLGLSPRQTEALRLLALPRPDLEQILETALEENVMLERLEPETGEGD
+PEVATVMEQTEPAGEWDELSWSSSAGTGERPDMQTFEDIRPPDLRQHLIEQLVLERFSDR
+DFLIALALVDSLDDNGYLREDLDTVSQELDALDPSPELIEIEAILHRVQRLDPIGIGARD
+TAECLSLQLEALPPDTAGLVVARELIDGHCARLTQADMATLASLTCSDEDSVRRALSLIQ
+SLNPRPGNDYSAQTAEYLIPELRTYRTPDGWQVELYPGNHPRISINATYVAWLSANRLNE
+ASQSLTRQLEEARWLIRSLAQRENTLLRVARVLVRRQTAFLDQGVMHLAPLTLREVAKEL
+DMHESTISRAVQGKAMSTPRGVITLRHLFSNALSNDNDEAISARAVHERLRHLLNHEDPA
+APLSDAALAAALARDNMPIARRTVAKYREALGFASTRARKRPAHSVAISKG*
+
+>NODE_2#PROKKA_00130
+MMKKLMNILFLSCLKATELIEKKLYFKLSLKEKVQLKAHKMMCDACTNYEKQSIFLDKGI
+SHLNQSKIKKEDLEEIKKSIQQKLNELK*
+
+>NODE_3#PROKKA_00188
+MSEANPYIRNQFLIAMPYMQDPNFNGTLTYICDHNDQGALGLVVNRPLDFSLGEILEQLD
+IECGHLDVPVYSGGPVKVERGFVLHRSRGEWQSTLEISGDLSVTTSRDVLEAIAEETGPE
+DYLVALGYAGWGAGQLEQELAGNFWLTCPADPDILFNVPWQQRLPAALARLGIDWSQLSD
+SVGHA*
+
+>NODE_17#PROKKA_00045
+MSETPRRPRDSRYMWRGIRPSEEELKTILEDHAQWLERLRSWEYSWREFIEEIPPPHDLS
+GADLLEADLSDADLTWAKLSNAILFEADLSNADLREADLSNAKLWWADLSDADLTWAKLS
+NAKLLAADLSNAELWWADLSNAKLIKADLSNADLTGADLSNCDVTGVRYHGPWLGIPFIQ
+IRKPNKLTCRGIRADTCYGSPRFRRDVMDQDFLEEMRETTGGRWLYRLWWLTSNCGRSFI
+RWAFFSLSLAVAFACVFCSSLGPECFDLHRAEGSRWVAEVAGRYLEVDPAYLGTTAASRG
+LPGDFWTMLYYSLVTFTTLGFGDVVPLTPWAAFWVTIEVVTGYIMLGGLVSILASKMARR
+AG*
+
+>NODE_1#PROKKA_00067
+MPTRRELANAIRALAMDAVQKANSGHPGMPMGMADIAEVLYNDFLRHNPANPHWPGRDRF
+LLSNGHGCMLQYAALHLSGYDLSMDEIRNFRQLHSKTPGHPEYGHTPGVEVTTGPLGQGV
+ANGVGLALAEALLAAQFNRPGHKVIDHHTYVFCGDGCLMEGISHEAASIAGTLGLGKLVM
+VYDDNGISIDGEVKGWFHDDTQKRFEAYGWHTIGPIDGHDAEALKKAFAEAQIETKRPSL
+ILARTIIGFGAPDKQGTAEAHGSALGDAEVAKARKELGWKFPPFEIPESIYAGWDARARG
+EQAETEWHERFAAYAKAHPQLAKELKRRLAGELPADWATTVEQHIAHVARNGKAQATRKA
+SGATLAALAPTLPEIVGGSADLTPSNDTCWPEAKAVKPGTPEGNYLHWGVREFAMTAILN
+GMAVHGGFVPYGGTFLTFSDYARNAVRLAALAHYPTILVYTHDSIGLGEDGPTHQPVEHV
+ASLRAMPNLTLWRPADDVETAVAWRDAIERRDGPTMLVLTRQSVPHYERKAQQIEAIHRG
+GYILHEPQNAPRALIIATGSEVDLAMQAARVLTEENLPVRVVSMPCQELFLAQDVDWQEH
+VLPAQVTARVAVEAGVSMPWYRFVGIHGRVVAMERFGESAPAKQLFEEFSFTAERVAAAV
+REAVAAAAG*
+
+>NODE_3#PROKKA_00170
+MHLWRIVWVLIVLVAVLGGVYFLFPGTIVNADKSFELWRAGLAVHDINVDDQHIHYVDSG
+GQGRVVLMLHGFAADYYSWPRMARYMKAGYRVIAPDLPGFGQSSRIAADNYGISQQAQRM
+HDFLRALNVDKVDIVGNSMGGWIAAEFAARFPAQTRTLTLIDTGGITAPHPSPFMQAVEK
+GENPLVVHNRAQFNHLLTIVFHHQPFIPGPLKGYFAKQAVEHAAFNEKVFKDLTDDYVDL
+EPLLPKLTMPTLVMWGRYDQILDPSCVEVLKAGLPNATIKWFDTGHAPMLEQPKASAEVL
+KAFLQANRGD*
+
+>NODE_3#PROKKA_00187
+MPDLKPEGQRQVMAFDFGLRRIGVAVGQEMLGTASPVTMIGARDGIPRWDEVEALIADWK
+PDFFVVGLPLNMDGSESEMCRRARKFARRLHGMYHRDYAMMDERLTSFAAKSAIVEREGG
+RDFGVKGVDDLAAVLILEGWFLQQRDQQPKIPTP*
+
+>NODE_3#PROKKA_00169
+MPPTRRSPPRQQRVTAKKAGGLSRLRIIGGQWRSRQVPFPPVEGLRPTPDRVRETLFNWL
+AGDIPASRCLDLFAGSGALGLEALSREARHLVFVDTASEVIRTLRENLRTLGCQQADVFQ
+QDAEQFLQRPPATPYDVIFLDPPFRQGWLDKVIPLLQQPGWLKPGGWVYVEHEAELNARP
+WPSHWHEHRQKEAGQVVYRLFHVADALKDTAEGVERAS*
+
+>NODE_7#PROKKA_00275
+MRKRKPKVDRIFHALGDPMRRVMVELLRKRPYSVSALAEPLGITLTAVGQHLKILEEAGL
+VRTEKLGRVRTVQLEPEGFAVLEAWAAEHKGEWALRLDRLGDVLADDG*
+
+>NODE_6#PROKKA_00238
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_7#PROKKA_00263
+MVRMTVLASGSKGNSTVVSSSRTRLLVDAGLSCREIFRRMQAAGEDVESLDAILVTHEHQ
+DHVQGLAVTARKLGIPVYFTEATHRAWMRWMTPRKRLTYAQWLEQQKAIVAAGKEPAAAG
+AEAQDAAEEDISGAKPKKDPCALPAVEYFSSGTDFQVGDIAITPYTVPHDAADPVGFVFE
+AEGVRLGIATDLGYVTPNVHLHLKKCDVLMLESNHDVDMLRDGPYPWSVKQRVMSRVGHL
+SNDAAADFLENSYDGRAAFVVLAHLSESNNLPELARVSAERALRDRMNLLGNKLMLASQQ
+TPLEPIVL*
+
+>NODE_2#PROKKA_00128
+MMVMSQLDQGKILSMTGLSVKSHSFFIGNPNVGNKAFSADPAAGLVIPVRVNVYEENGKT
+YVSYFKPSDLFGSFKNAKVKMIGQMLDKKLGMMLKMVTR*
+
+>NODE_29#PROKKA_00107
+VLKASFLASVVSFLCFCPWNEQWKSELIANNFV*
+
+>NODE_6#PROKKA_00252
+MAVEAVRGLLEKTGTKPEEVDLVICATVTPDMQFPATANLVSYKLGINNAFSFDMNAACS
+TFIYALITGSKYVESGEYKKVIVIGADKMSSIVDYTDRATCVIFGDGAGAVMLEPTASDE
+PGIMDHRFYTDGAGWIHLHQKAGGSLKPASHATVDAKEHFIYQEGQPVFKFAVTRMADVA
+AEIMERNQLKSEDIAWLVPHQANLRIIDATARRMGVSKDQVMINIQRFGNTTNGTIPLCL
+YEWEPQLKKGDNIVLAAFGGGFTWGSVYLKWAYDGKK*
+
+>NODE_12#PROKKA_00029
+MQRSSGSITQLARLVESLAELLRLHYGPDGLPAAQEEDLCSQEVEGRRLGELLAELWPDS
+GPWRGPCLGQGAIRETERLLRYRLQQAEAQNRALATRLERVRRQVAAQRRTLLEQLRAAR
+LQVEQGQARLEALSAELGGLRAELERRRERARRRRRYLEGVVPRGMNRFADAGGRILDQA
+TLRRATRELRELQALVVRTKDACARLEHRWARARLELARARSHEAGLRAELARLEPYWQA
+KTHRLARAKVVLAARQEELGPLERNLHRLRVMGLAHAEVVSRGRAALEPLLAPLASGESP
+DPVESLEESLTQAGEQARRGRRLTALMERLGRRLERRLEAIGPVLKEQRRLNKEITRLEN
+ELPGLLEPLLAGDGADPRNRQEAGARFSLLIARLEDLIPQARATQEQLDELRQALTIGLS
+RGKAWQAAWRRAGKAERAALHQAQALVEEVRLAARQAARQAEHLRRRAEPAVKALSPLRS
+QDLLPSLAALAQGVSRGQLKARQLEARAAELEGRIPRPYFGNLSKPPVALKPVSAGLRRL
+SGKQVELERLAALERAARRWQGLLDGPLVEEIRRPVEQVALRLARSLTLLERQKNLLASR
+HQKQGRELSTLKAELDQRRRREELARRRLEQVRDRNRRQQRTIRNYETELKQAQTRAALA
+QRLEDELARLGEHAQTLARRLERSDKLAAALKRKSLERHRLYRRSQYAVEWLDYWRERAL
+EQEKLLSSARAELELARREYQQARSLLASAVSERDQALKELATERAARARQALDLLGGKA
+LSVELAASRSEAGRWAKLAQDMALALAASGEHHRQETADLRAQVDQLSAEAAMLKRQLER
+IAAMVEVQVPGLEELADLPPAPSWRRPVALRLVPLGPKQVAQALDRLSAARRRLQNLGRG
+TLGHWALIAALTCGLVLTPPGTPSKATRADAPLKPPRPVLRHLAQGSPLTPIYQVPAQAR
+LLGDKVARGSLELNLLPLRGQPVAVPQSVKRRLKELAREAGLSPKVLLTSARALYAGQAA
+VDPSALEELAHTARQLARRHPLIFRELSRRGLPPAASAVAALAPEPEKAQHLFLDRLYRE
+YRSLGFSAEEALGALAANQRAFHRLTRQWTPPRRFIGKVQPVEAVEKMGLREFLQKITPY
+IQSKLKVFLRQRGMSYSGDLTLYAKNLAFDMYCAAKKFQVPVTLLLAIAHQETWYANVLG
+DANRSASPFQIYEPTRELIIKSMAEAGFVPPPKRIKLQRHLTMATFMASFHLRELMQRAY
+TPPRRGRQAVVNLDRVLQRYNGSSRYAAQVALRKRQLARFLRRQG*
+
+>NODE_7#PROKKA_00283
+VRLAQDAPVSFDPDTFKVTPPDPAVITPVLAQLEFNQLLNQFAAPPPKADYRRLSDPEEI
+EDFLKPVARKKRLAIDTETTSIQPMLAELVGVSLCHQAGEAVYIPVAHNLTPGQSQADKE
+AVLQTLAPVLADPAVTKIGQNIKYDLIVLGRCGMEINGPLFDTMVASYLLNPGKTSHNLA
+SIAAEFLGRSVISYQEATGGKNRPFADTDLDQATDYAAEDADVAWQAAQVLEKKLAESHL
+DGLFRDLEMPLVPVLARMERNGVGLDVQGLEDLGKELAAKLDEIERTCYRLAGHEFNLNS
+PKQLAQVLFEELGLTPVKKTKKGKTSSTDVSVLTVLAAKHPLPAEVLNYRTLSKLKSTYI
+DTLPKLVNPQTGRLHTSFNQAVTATGRLSSSDPNLQNIPVRSEIGERIRACFIAEKGNLL
+VSADYSQIELRVLAHLSRDPLLVEDLTKGLDVHTQTAARLFDVMPELVTKPMRARAKTVN
+FGILYGMSAFRLAREQGISRKEAQQIIDKYLGRYQGVARFQEENLRQAREKGYVTTLLGR
+RRYLPAINAGDRLARQAAERMALNTPIQGTAADIIKLAMLAAHRLLEERFPQALMILQIH
+DELLFEVPASQAEDLAQAVKQAMEGVIELAVPLVVDIGIGPDWAQAH*
+
+>NODE_2#PROKKA_00149
+MKKHLNINEPTRIRITKEFKFEMAHALKGYDGLCRNIHGHSYELMVTVSGFPIEEENHPK
+LGMVMDFGDLKKIVKEEIVGQFDHALVLSKKMPVPLVDELKNQFERIILTDYNPTSEMML
+IDFAARLKARLPENITLKHMLLRETVTSYAEWFAEDQD*
+
+>NODE_1#PROKKA_00062
+MNAKPHVLVLGGNFAGLGSAQKIREFAGDAVDITVIDRKNYLLFVPNIPADVFENKDPAV
+GQRLDLPPVLVKDDIYFVQGEVTELDVDNRIVHYTPSERPGAAPQKIAYDYLVVALGNRL
+AFDKIEGFDEFGDSVSDIYLGNKLRKKLWEGGYKGGPIAVGSAMFHQGDGAKGLEPYPGG
+SIPDALAACEGPPVEVMLSAATYLKKTGQGGPEKITVFTPAELIAEDAGEKVVGQLLDIA
+SGMGFNYVNNAKDITRVTAEGVELANGQTIEAELKILFPDWVAHDFMRGLPISDSEGFVI
+TDLLMKNPKYPEVFAAGDAAAVTMPKLGAIGHQECDIVGRQIACAVGRMNEAAANTPLQP
+VVYCIGDMGDNQAFYIRSNSWFGGDTQVLKMGHTPFLLKMQYKNLFFRTQGKMPDWGLDF
+SELMAEKIAS*
+
+>NODE_3#PROKKA_00165
+MGTSLQVMDKLIPGANVQAYIQGVNAIPMLTVEEERELAARLQQDNDLEAARRLVLSHLR
+FVVHIARSYSGYGLAQADLIQEGNVGLMKAVKRFNPDYGVRLVSFAVHWIKAEIHEFILR
+NWRIVKVATTKAQRKLFFNLRSAKKRLAWLNNDEVTAVAADLGVEPRVVREMEGRLAAQD
+TAFDAPTDDDDDNAWQAPAYYLEDRRYDPAQQLEAADWTEDSNSRLLEAMDSLDERSQDI
+LRERWLSESKSTLHELADKYGVSAERIRQLEKNAMKKIRKMMGEESIA*
+
+>NODE_7#PROKKA_00271
+MHPQRSRAGHNNEPRHHVGKERAHHHVGPRSRVVLHSNALLHHRRLQIELHPRRNRRADD
+ADHHEQVAVLPPHRAVRQRHRLQYGQVPVGRGQHARRHISNVENRSHQKDLFHPLVIALD
+RQQPHQQRAHRHRGVLRHVEQLQAARNSGKLANHVAKVHHHQQHHHHKGDAQPELLADQV
+AQPLAGHHPHAGAHFLNHDQRQRHRQNRPQQLVAKLGSRLRIDKNSARIVIDVGRDDPRP
+QHRKEQKNPGSPALQHRVDSSLVCQLNSERA*
+
+>NODE_3#PROKKA_00182
+LENSTQNALHKPELAGKIADQTQLTRAQAHEVITAFTDQVSAAMARGETVALAGFGSFNV
+RERQARTGRNPRTGEALQIPAHKTVGFRPGKAFREAIE*
+
+>NODE_9#PROKKA_00321
+VKTVSISGQTGASKIVIGERLENLSNYLPDRRIVVITDTNVAGHYGKMFPDVEVITIGCG
+ESIKTLDTAKMIYERLVSMAADRSVFIVGIGGGIVCDITGFIASTYMRGVRFGYVATTLL
+AQVDASVGGKNGVNFMGYKNMVGVFNQPEFVICDPYVLGTLPPRELACGFAEIVKHAAIS
+DKDYFADLEESHEKACARDPETLERIIRKSVVIKAGVVNADEKERGERRKLNFGHTLGHA
+IEKTLGVPHGEAVSAGMVMAAELSANRGHLPRPDIRRLKDLLTHLDLPTALPIDPERIID
+AMARDKKRQGEKIHFVLLSAIGAAFVDSISLAELEAVVTG*
+
+>NODE_2#PROKKA_00124
+MIKYYLLLAFEKKTLIRAIRVAILVGIILNLINNPDFIFHFSTNYLSLGRVLLTFIVPFL
+VSTYSSVLSNSALRTGSVSHIDAILKCKSCNKTHIHVPIGHEVEECPICKKETRWRPVRI
+FSGSGNRDELLKSLALFARYNPTPLFRINSDSIINEANQAAKDIFGSDELTGKNLAGIIP
+EIKDINLNQLIHDGAIKKTIIHKEGRDYNITLKGIPELNSVHGYLNEVTNFVEPEQKG*
+
+>NODE_6#PROKKA_00246
+VAHAATTGNNETLLCRFPTLHNNTIVFEAGGNLWRVDRTGGVATRLTTDPGYDMMPRFSP
+DGKTIAFTGQYSGNVDVYTIPADGGAVTRLTYHSDVVRKAPTRWGPDNMVMTWTPNGKDI
+VFLSRRDTWNSWFGQPFEVSKMGGLPTHLPLPKGGVMSYSPDGSKIAYNRIFRNFRTWKR
+YKGGLAQDIWIYDFKTKKIQRVTKWKGTDTYPMWYKNTIYFASDRGANHRLNIWAYSLDT
+KTFRQITHFKNYDVDWPSLGNNGIVFQDGGSLYVLDLPSEQLHKINVKVPTDGTQTLPRW
+INASKMIRSLDISPNGKRVLFGARGDIFTVPAKHGATRDITQTSDAQEQYPAWSPNGKWI
+AYLTDASGVNELAIRPSDGSGHQTYITNAKTGYYYNPTWSPNSQMLAYSDNNHVLWYISL
+KDKKPVRIAQDKYNAMRDYHWSPDNNWISYSKTNASGLSQIYIYSLADHKSYKVSDGIYS
+DNDPVFGPNGKYLFFVSARHENPLFSESESNVATEKMDGIYMVTLQKNEKSPFAPVSDEG
+MPEAKKASSSASKKTESAKDVKIDFNGLMNRVIMLPIKSGDYGNIQVTGNKVFYQTRPLI
+TIEGFLHGTGQSSIMVYDLKSKKGHTVVANGARTYGLSADGKTLVYMRRGKFFLMPSASV
+NAKGSEPVNTSHMKMKIYPHQEWSEMFHQAWRLFNNFFYNTKMNGVNWNEVGANYGKLVP
+LLGCREDVNYLVGEMIGELDNSHCYVWGGDDNYLGKTNPTGVLGVDFGLNKSSGRYYFKK
+IYAGDNSRPGYGSPLDRPGVNVKTGDYLLAVNGHQLKAPMNPYSLFVNTVGQQTTLTLAD
+KPDGKGEHTVTVKPINNSLNLRLLNWIRTKRAYVNKKSDGKIGYIYMSDMESLGMTQFIH
+QFYPQLSKQGLIMDDRFNGGGFIDQIVLERLRRVLIGMSTNRAHAAMRYPEQVLHGYKAC
+LLNHYSASDGDMFPFYFRKYGLGPLIGERTWGGVRGYNRVWTLLDGGNLVVSQNSIYGLD
+SKWAIENHGVTPDIKVDNLPGQVMEGKDPQLDTAINYIMKKLKEHPMPIPQPPAEIPAYP
+SGNDAGGTN*
+
+>NODE_2#PROKKA_00127
+MNQEKKKLVLLAFVLLLAGISPNIFPAAQSGIASMSSLAVVLLIPSVVLIFILAILSQAL
+GYNDLRKQILNGILAGLAGTVGLEIVREIGFHLGGMPGDMPKLLGVLLLNRFASGPDFWS
+NVAGWSYHFWNGAAFGIIFSLIIGRGKIWMGIVYALLIGTGFMVSPATTSLGIGVFGLHF
+KDGYQFLTTVYLAHIAFGSIVGLVVYKKNKDAPNIFKRLKLAFS*
+
+>NODE_2#PROKKA_00121
+MSQAEAPVIIKPNFKITNFLSKEPRSSLIHEIFSGLTAKQKYISSRFFYDRKGSALFEEI
+TKLPEYYPTRTEKSILSAHAKEILGNPESLVIIELGSGDCSKISILFDNFPEQKMSNVKY
+IPVDVSESAIIKSAEILSSRYEGLKIHGLLADFLKHLDLLPGATPRLICFFGSTLGNMTR
+NQATDFLWNLKNIMNPGDRLLLGLDRVKGPEILYKAYNDKQGITAQFNKNILNVVNDVSG
+TNFKTSDFGHLAFYNQNENRVEMHLKALYDMRITSKHFRDDIFIVKGESIHTENSHKFLP
+EQIEQLALSSGLKFQASFTDVNKYFSLNLFEYPKLK*
+
+>NODE_2#PROKKA_00117
+MGLSYRINFKLGANAMVISDPSMPVPASLQFRQLKSDEYVMLDIPTDSLEVAYWGTKKPV
+PAQYVLTEAQTAKVESAITSYNAEIKSLAKKYNLAFVDFNSIMKSIEHGGLTVDGIHFTT
+AFITGNLFSLDGVHLTPQGNAVVANYFIQAINKQYGSHIPSVMVSDYPSVVFP*
+
+>NODE_1#PROKKA_00091
+MKLMETLNQCINAGHEMTKAIAIAQFNDDSPEARKITRRWRIGEAADLVGVSSQAIRDAE
+KAGRLPHPDMEIRGRVEQRVGYTIEQINHMRDVFGTRLRRAEDVFPPVIGVAAHKGGVYK
+TSVSVHLAQDLALKGLRVLLVEGNDPQGTASMYHGWVPDLHIHAEDTLLPFYLGEKDDVT
+YAIKPTCWPGLDIIPSCLALHRIETELMGKFDEGKLPTDPHLMLRLAIETVAHDYDVIVI
+DSAPNLGIGTINVVCAADVLIVPTPAELFDYTSALQFFDMLRDLLKNVDLKGFEPDVRIL
+LTKYSNSNGSQSPWMEEQIRDAWGSMVLKNVVRETDEVGKGQIRMRTVFEQAIDQRSSTG
+AWRNALSIWEPVCNEIFDRLIKPRWEIR*
+
+>NODE_13#PROKKA_00039
+MKIQQIIIREFEEMMAELKEVLAKMTCPLLGEDWLPM*
+
+>NODE_6#PROKKA_00256
+MEEAKNTYSKALDLLKNGLLKEGFVAALDQQANYRRVWARDSIITGLSALLADDTTLIEG
+MKKTLISLKQHQHANGMIPSNVSFDADGNVTMVSYGTLTGKVDTNLWFIIGVMVYVRKTS
+DTDLLKEMLPAIEKVFELLLSWEFNGRGLLYVPQGGNWADEFILEGYNLSEQLLYYWALS
+EASAMDEKFSTKAKKLKDLIEINYWPTESNRSKVYHKTAFERQLEKGQTSHWLPGFKPAG
+YHTFFDCFAHGLSFVLQFNSPEQEGEIIETLVRTTSETSGSLLPSFWPPVRETDAQWETL
+QTNWIYKFRNQPGAYQNGGIWPISNGLLIAGLYRSGHKGMADKMKEALFLATALPENQFG
+FYEYIDAFSWEPGGAKHQLWSAAGVIFAEKAAQNVFIV*
+
+>NODE_3#PROKKA_00193
+MSAQAAPFAVLSDIATRSRSQSRGLPAQEEAVELWNGIGFSLAGQLYVAPMGEVVEILHL
+PRYTQVPGVRAFMVGVSNVRGRLLPLVDLGLFLDFPRSVV*
+
+>NODE_3#PROKKA_00178
+VSNTYTDLSSARLVELALERNEGKLAANGALVVNTGRRTGRSPMDRFIVEDPATAELIHW
+GPVNRPFDAAKFDALWERVESHLEERDQFVSYVHVGADPEHYLPVKMTTETAWQNLFGRN
+LFIRPDNYNPIDKGEWQILNAAGFVCEPERDGTNSDGCVILNFAERKVLIAGMRYAGEMK
+KAMFSVQNFLLPEQDVLPMHCSANVGEDGDTCLFFGLSGTGKTTLSADEDRYLIGDDEHG
+WGRGTVFNLEGGCYAKCINLSKKNEPIIWDAIRFGAIVENVVIDNDSREPDYDDVSLTEN
+SRCAYPLEHVEKRVLENRGGEPRAVIFLTCDMTGVLPPVSILNKEGAAYHFLSGYTALVG
+STEMGSSAKLRSTFSTCFGAPFFPRPAGVYANLLMKRMEEFGSRVYLVNTGWTGGPYGVG
+KRFSIPTTRAIIRGIQTGALENVQTQHLDDLNLDVPVEVPGVDSNLLNPRNTWQDKEAYH
+HKAQELIAQFVENFKKFDVSDAIVNAGPKLKD*
+
+>NODE_4#PROKKA_00219
+MVKKAPEVDVPSAKDRNFVTALARGLELLRAFGPEDDYLGNAELAERTGIPRPTVSRLTY
+TLIELGYLRYCERLEKYRLGAGVLALGYRYLSRMGLRELARGPMQALADRTDCLVALGTA
+DRLDMTYVETCQGAGPLVLRLEVGSRIPMATSAMGRAYLAALPDARRNEYREKIREVYTD
+DYEAIWQGVEQGVEQYQKLGFCTALSDWNPHIAGVGVPLVLDGGSQIMAFNCGGAAMRLS
+RSVLEKKLGPQLVEVVAEVQRQMHGRRLEAVS*
+
+>NODE_1#PROKKA_00081
+VRLSRGWAVASAWAALLGAAALTSWLFLRSHDHSPATDLASHAVERPDYLLHQAIVTRFA
+KDGSRRYIIKARRIAHMPRNNIALLTRVDLDYFPVHGKPWHLQSDNGRLFANGTRLNLIG
+HVRAHELDTPIPVHFLTTEVTVLLPEARLASRYRVILRQGHRETRGTGLAANLQTGTLSL
+LKDVTSQYAP*
+
+>NODE_8#PROKKA_00286
+MERSSLALPCSGGSCLHAAVRAQMTMQRTAFSLSIALSAVLASALLVGIVPLLRGGDNYE
+LAVKSALLVLVVGYAWLHWRAVTRRGRCLLKAAFCLNALVLVPLGATAALCHVFGGPKIV
+PREAGAIGGAIAILAAAAAAMQVILLTRCRTIELTVPKGD*
+
+>NODE_11#PROKKA_00025
+MPMDWTPPPRGGGREPDINQVVQNLKNRLPVFKKARGLWLAVAVVLAIILGASSYYTCS*
+
+>NODE_1#PROKKA_00079
+MSQLRAENLHKRYRTREVVRGLNLNVNSGEIIGLLGPNGAGKTTTFYMILGLVPTDSGNI
+YLDQRDITGLPIHARARAGLGYLPQEASIFRNLSVRDNLIAVLELGGHGTRAEQQRRADE
+LLDELGVTHLAKDKGISLSGGERRRVEIARALANEPAFMLLDEPFAGVDPVSVADIKRII
+DHLAKRGIGVLITEHNVRETLDICNRAYVMNRGTMLAEGSPKEIADNQTVREIYLGDKFT
+L*
+
+>NODE_1#PROKKA_00083
+VNRPASATGLIESGREVIQIEAAAVSALESRLNETFAAACGLLLACRGRVVVTGMGKSGH
+IGRKLAATMASTGTPAFYVHPAEASHGDLGMITSEDVMIALSNSGQTPEVVTIVPLIKRL
+GVALIALTGEPDSMLARASDCHLDISVSREACPLNLAPTASTSATLAMGDALALAVSAAR
+GFTPEDFARSHPGGRLGRRLLVRVADIMHTDDAMPIINESTRLGDALVTMSAKGLGMAMI
+TDVQGRLAGVFTDGDLRRHLDQGVNLDTPMQHLITRECTVATPDMLAAEALRLMETRHIN
+SLPVVTDDKPVGAFNMHDLLQAGVV*
+
+>NODE_4#PROKKA_00222
+MQYSSDEISNSGLDRPRAGGYRLRLALSGLGWGSTALMFALLALALIAIIAFVVIRGGAH
+VNWATLSQTTQGYHGLLNAIEGTLLVTVGSLLIAAPVGVVTGIYLSEYQHRRSARFFSFL
+CDVMIGVPSIVLGMFGYIAMVNFFGWQFSLLAGCITLSFMIMPYIARTSELALLQVPNSV
+REAAYALGAGDRVVIFRVVLASCVPQILNGLLFAAAISMGETAPLIYTLGWSNYMWGGEF
+FHHPVGYLTYVIWSFISEPSSAAHQLAYVAALLTTGFALLINILARSTIRKQSQHQSQ*
+
+>NODE_7#PROKKA_00274
+MEKPTVIHSSFTLERSYPYPAEKVFAALADPEKKRRWFADSPNHEVVKFAMDFREGGAER
+MEYRFNEGTPFPGVMLVNSGHYEDIVPGRRVVLCSTMTIAGRKISVSLVTFDLLPQGEGS
+ALLCTFQGVFFEGADGPEMRKAGWEFLVERLGEEVAREG*
+
+>NODE_1#PROKKA_00051
+MKVRASVKKICRNCKIIRRRGAVRVICSDPRHKQRQG*
+
+>NODE_7#PROKKA_00266
+MTKNQDCMTLPVRWEQAPAREDFWQELRTASRWLLLLDYDGTLAPFHQDRMKATPYAGVK
+ERLEQLLKIEKGRIVVISGRQIEDLKQLLQLSQPVEIWGSHGREHLLHDGSYRLVDLTED
+ERRVVEAVTARMSERGWAGQLERKPTAIAVHWRGLPVSEQKELREAAEQYFAEANPPDTL
+EMMPFESGVELRSRSRTKGQVVAEVLAEEPADIPTAFLGDDWTDEDGFAELRGRGVGILV
+RPEARESCADYHLTPPEELLEFLDRWLENAKESIR*
+
+>NODE_11#PROKKA_00014
+MKRAPFITLEGGEGCGKSTHASLLAQRIRELGLPALLTHEPGATELGGALRRLLADPAGP
+DPCPQAELLLYLADRAQHLEQVIRPALAAGEAVVCDRFADSTQVYQGLARGLGADRVREL
+NRWLCGDTWPDLTIVLDLDPALGLARARHRQGKQGLDRLEQAGGEFHRLVREGFLELARQ
+EPERVRLIEAAGSRPEVARRIWEVARPLLESWRKTREA*
+
+>NODE_4#PROKKA_00210
+MLDAYLYDGLRSPFGRHAGALSPLRPDDLLATVIQALIARSGFAKEQIEDIVIGCTNQAG
+EDARNVARHAGLLAGLPVETAALTVNRLCGSGLAAVADAARMITCGEGELILAGGVESMS
+RAPFVMAKAESAYSRQLRTFDSTIGARFPNPKVLAEFGSDTMPETADNVARDLGISREAA
+DAYALQSQQRYEAARQDGFYREEVLPVEVPQGRKQPPRWVSADEHPRPDTDTAKLARLSP
+LFEEGVVTAGNASGINDGAAALLIGSRSVGQRLDIKPRARILSAAAAGVPPRVMGLGPVP
+AAQKALARAGLSLNDMDIIEINEAFAAQVLGCCQQLGIAGDDPRLNPNGGAIAVGHPLGA
+SGARLTLTAMRQLERINGRYALVSLCIGVGQGVAAVIERM*
+
+>NODE_7#PROKKA_00259
+MAKGGLGVVVRGIPGYRARIRPIVSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAG
+VIAKRPAPIALPNSCAAEWRMAPDAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_4#PROKKA_00199
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_7#PROKKA_00270
+MPVRLMPMPEVDAKVTLTMLLGTPVTDATGKLRGKVRDVAVATGAEAGRVAGLVVKNRDG
+LQVVTSVDLRRTPSGTLELRADAQMRPLTGEESFLLLRQDLLDRQIIDVHGRKVVRVNDV
+ELDWWNQERGAAGQQESLRVTGVAVGLRGALRRLLLGLMPQATLDRLARKVPQRSIPWEF
+VDIVEVDPARRVKLKIEHERLARLHPSDIADILEDLAPAEREALLRSLSEELAADALEEL
+DPKLWRSLLQSMDSETAAGIVEEMDPSAAADLLADLSKADSEAILGEMDPEERQEVKELL
+EFREDSAAGRMTTEYVAVPEDATVADCVAALREFEGDPETITEIYLLGEDDLLVGVVPLA
+RLVLAREETRAQVLSEPETITCELEAHQNEVAELFDKYNLRALPVVDEQRRLAGVVEADH
+VIAFLRERR*
+
+>NODE_1#PROKKA_00049
+VSRITIHWPSFYNVVTGKTLALPNLIALQHIPLSPAGVIAKRPAPIALPNSCAAEWRMAP
+DAVFSPYASVRYFTPHMVHSQYNLL*
+
+>NODE_1#PROKKA_00075
+VLAGIAEWYGEDEAVPFRVISGTSAGAMNAAYLSANMENFAHGTQRLAQVWSQLEAQQVY
+RPEYRKVFGALLHWAWSLLSGGLGDSNPRSLLDNSPLRALLAENIDFDAIARNIERGLLR
+GVSVTVAGYSTERSLSYFQAETGVQSWWRQRREGRPVQMTLDHVMASLGLPIIFPAVKVA
+GEWCGDGSTREFAPLSPAIHLGAKRVLVIDTQYPAPQHVLGQDQAYPSLSKIMGYLFDSV
+FSDSLYADLERTKRINRTLDYIKRQSGHEPPELGLSHIDTLVIAPSRRPLEIASRYESHL
+PKSMRWILRSLGGDVSSGDQLLSYMLFQSGYCSEMVALGRHDAHARREEIGQFLGLSKIK
+VR*
+
+>NODE_3#PROKKA_00161
+VKIHSQLRNSTFQIALLYMVVFATSVFLLLAFIYWRTAGFMTAQTDETIEAEITGLAEQY
+RSRGINGLIAIVRERVARDPNGKSLYLFTTSDYDKLAGNLSAWPQNVQASNGWINFTLND
+SVGWRGEPHLARARVFKVQGGLRLLVGRDVQELTTLKHLIERAIDWGMGITLALSLFGGF
+MISRSTAKRIEVINQTARKIMNGHLSLRIPARGTGDDFDQLADNLNQMLDRIVHLMEGIR
+HVSDSIAHDLRTPLTRLRTQLENTLLTVEGDAARDQVARAVAETDQLLATFNALLRIARL
+EMTGHSADKSPVQLGPLVHDACELYEALAEDKEQEFVLDIPQDVTIEGDRDLIFQVVSNL
+IDNAIKYTPPEGNIRVLVTQEEDDAIFQVEDSGIGVPDSEKDKVFERFYRVAKSRSQPGN
+GLGLSLVSAVVDMHQGRIELADRYTDGRENPGLKVTLRFPRLKPNRRKEIKPTSTTEPEG
+SAS*
+
+>NODE_8#PROKKA_00296
+MRIATFLLPLLVAIAGAAPKVETGTDGLRVRTARYVATFSTDSGLLASLALVDGTPLLTS
+PRLYADVLPDGRKNFSAKAKAAPKAKPQPDGSLLVEVAGALLDKDGKPHPTYPFTYTASY
+RFDDTAQVRVSVSVIPGFDSDAVFGFLGQVLSTASQREFFVNTADGLISEMAATHSGRTY
+QSESEPLDLKDPYLGVLLKTGQILQFRLVSGAESLLNVFFHDSGAGPTHLFLCPLSGSNP
+RQAKTGKAWQQELVIEAMPLAEWTKSR*
+
+>NODE_6#PROKKA_00242
+MLEQKELILLNISGEDKPGLTASLTEILSQHNVNILDIGQSVIHKDLGLGILFEVPKKYR
+SASILKDLLFKAYELKSHIKFTPIPIEEYEKWVAEQGKERFIITLLAHKLTALHLSKVSS
+LIASQKLNIDTISRLSGRKSLNGNNKVTNSVVEFSVRGTPLDINAMKQSLMNIASETGID
+IAFQEDNIYRRSRRLVCFDMDSTLIQTEVIDELAQKAGVGDEVKKITESAMRGEIDFKES
+FKKRVSLLKGLDESVMKGIAENLPITNGAERLLSTLKQYGYRTAILSGGFTYFGNYLKTK
+LGFDYVFANELEIKNGKLTGKHLHEIVDGKRKAELLELLAFKEDIHLEQVIAVGDGANDL
+PMLEKAGLGIAFHAKPKVKASAQHAISATGLDTILYLLGFRDREINAS*
+
+>NODE_1#PROKKA_00072
+MSGDSILRIFWWLVLGAWMSGIGVMLGRELGLTVLLRYLGRNESERRELLAPHIERPSEG
+HQVWLLLGGGALMAAWWPLFTATLFGGLWLVLLFMVLAVLVGPVGHGYRKRLSEHTRGPW
+DLLWAGISLAALLVFGLAIGATVSGVPLHFDAHMDAMWGGFFSRFTPYSLLVPGLMAITF
+GLWLAAARAAHECTGAVAARARALLLPVGGVTLLIFAGGAAWATQLPGYAVGGLPKVGAS
+PLDGTTFAVGGAYLERFLSHLPLVIVPVLTALAIVGALFFSWRGRLQRVGPLVVIAVVGM
+VATLGAMTYPVILPSFAEPAQSLTLWNAAAERPVLVAFLVWLGILVPVVLGYELWLRRRN
+AQTVVAGSTAR*
+
+>NODE_2#PROKKA_00135
+MKRLGKHFAVLILAAGYSGRMGMPKAFLPYDANRTFLEKIVSEYLEFGCNLVGVVLNEEG
+MKLYEKMQLEHKNNITAILNPAPEKERFFSLQTGLKRLKSEGAVFLHNVDNPFLTQDILQ
+ALASAFKTQAYVVPTYHEEGGHPILLSQEIVKALIETSDYEQNLRVFMESYDQIQVPVSD
+PNVLANINSPQEYERLFGRSF*
+
+>NODE_13#PROKKA_00040
+MAVDKNEFFRQATIRICGSLDIETALERCFHYLEQMLPVDEIGLYLYDPGLNVFQRIAGV
+KSHGKNEFSPVSPLPEASKEKWSAIWADMGDITIINRVEERPEIQEVIEMYGLEHDISLM
+SMRLELEGKRVGLLLLRTRGRDRYEEKHARLMLLLHEPFAIAMTNALQHQELIRLKDILT
+DDNRYLRRQIRDLSISEIVGADLGLRHVMEMVQQVTQLDSPVLLLGETGVGKGVVAHAIH
+DASPRKNAPFVSVNCGAIPESLFDSELFGHEKGAFTGAIAQKKGRFERADKGTIFLDEIG
+ELPPHAQVRLLHVFQEKIIERVGGTTPISVDVRIISATHRNLEEMIRSGKFREDLWFRLN
+VFPIHIPPLRQRKEDIPALVHHFIEKKTIDLKMQEQPRLSPGAMDQLMAYDWPGNVRELE
+NIVERALIQFKGGMLRFDGLIFSPIASSRGGGHETTDRFLSIDEVNAIHIRRALKVTNGK
+INGPGGAAELLGINPNTLRKRMNKLNIPYKKKEIGQGVD*
+
+>NODE_9#PROKKA_00305
+VKRTLLSTAIAVLFLLSAVSVYAAQKKPYKVGCVFAITGGASWLGGPERNTAEMLAKQIN
+AAGGINGHKLELFIEDTQGDNTRAVNAVKKLIKKNHVCAIIGPSRTGTSMAVIPIVQQAK
+IPMISCAAAESIIAPVSKRKWIFKTTQNDSDAVRRIYENMDKKGIHKIGIITGTTGFGAA
+GREQLKALAPHYKIKIVADETYDPTDTDMTAQLIRIRNSGAQAVVNWSIVPAQSIVPQNM
+RQLKMKIQLYQSHGFGNIKYVEAAGAAANGLIFPGGRLLAADTVSASNPQKAILMKYQKE
+YEAAFKEPPSTFGGHAFDAISILAKALKKVGDNPAKLRNVIEHTNFVGITGVFHYTKTNH
+CGLNQNAFEMLTVKNGKFVVLHQ*
+
+>NODE_1#PROKKA_00087
+MTEKPRPSRKPYLVRALHEWMGDASLTPQIIVDATVDHVDVPVEHVHDGKIVLNLSLEAV
+RDLELGNDAITCTARFGGVARSLWVPMKAVLGIYARETGEGVAFACS*
+
+>NODE_4#PROKKA_00204
+MQRTARAALCREWNGPIQVETIRVDPPRRNEITIKLRACGVCHSDLSAATGVIPFPPPLV
+LGHEGAGTVIAVGEGVTDFQEGDHVVSSFIYMCGKCRQCSRGRPVLCEQAHKALHHLPDG
+TVRTHDGDGNPLNVFGACGVMAEYATLHVNNAVKIDPDVPLERAALVGCAVMTGAGSVFN
+TAQLEPGSTAAVFGVGGVGLNAIQGCAIAGARVIVAVDTNEEKLAMARQFGATHTVNARE
+HDDAGKAVKKMTGGGDYAFECVGSGVTVAQAYGSLGRGGTAVVVGVADVKDKTTFRTLSL
+PADERTLKGSWLGSARPQFDFPRLLGLYQGGRLKLDELVTHTYTIDEAPQAFEDLKAGRN
+ARGVILFD*
+
+>NODE_21#PROKKA_00095
+VVAFGFFHIETPMLLLEELFFFAPEFCDALVRLAQAPPERDWQGSWTGFEIPDPASRGDL
+HGAIAGRRLEGFIGALYARWPFPRDPHQFRQRTRGAAPREVVEQEAESFGRRREVVLEAR
+AGGGEFAIGQYRFHRTGFLALVDYVWRGGMPGWEGGRRPEWLLEAARRIQESDSPWLAGL
+DWDPARLGFTI*
+
+>NODE_2#PROKKA_00111
+MNPLLLFILIVSGGLYLAGHYLHKPILKYIFKPFTTFIILFFAFMQLPDVSVQYKDYILI
+GLLISLIGDIFLLWPEKRFIHGLGAFLLAHVLFILAMVSDFGPYYNWQYLIPIALYMVIF
+LWIILPKSGKFVIPIIVYALVLMVFFWQAAGRAIYLAESSSMQAMFGATLFVASDSILAY
+NKFVKNYKWAEFFIIITYWAALYFIALSV*
+
+>NODE_1#PROKKA_00050
+MFLAGALIVFRIGIHVPVPGVDPTAYAHLFNQNAGGILGIFNVFSGGALEQMSIFALGVM
+PYISASIIIQMLTSVVPSLEALKKEGQAGQRKITRYTRYSTVALALFQSLGAAFALQSQG
+VALTAGPGFIVTATVSLVTGTMFLMWLGEQVTERGLGNGISMIIFAGIVAGLPSAIASTL
+ELVRNGELSSIVAILIFVGVLLITAFVVFVESGQRRITVNYAKRQQGRRMYAAQTSHLPL
+KLNMSGVIPPIFASSIILFPVTLAGWLGQSSGFGWLNTLQLWLSPGQPLYVALFAVLIIF
+FTFFYTALTFNSDETADNLKKSGAFIPGIRPGKQTAGYIDTVLTKLTLWGALYLTAVCLL
+PEFLIAYAHVSFNFGGTSLLIVVVVAMDFMGQLQAHMMTHQYEGLLKRARMRGLQR*
+
+>NODE_7#PROKKA_00282
+VSACSHRPDARPLRIGQAQKDLRIPANKLHQEASPAGPQQILGRHLSQLPRRPRPAPPPE
+DIEDNAGPDKLKNRRRIHFLCCRHNSVRIAHPEPHLRRNAVIPVSGQLASNAPDSVPQRR
+RGHAQIQHPQGTNLIGPGLEQQRQNPGNHPAKPGKPGPADQQRWMMHQQHWLFQHMVELC
+AHHSSHRRKGDDADRIGINLPALEVLVKEVAPDHRGKPHHDAVCANR*
+
+>NODE_2#PROKKA_00144
+MEFKFEKLIIWQKAMEFGEEINSIAHKFPKDEVYNLSSQIRRAVDSIALNISEGSIGQSN
+LEFKKFMSYAIRSLAEVVSCLHKAKRRNYITEDEFKKQYEFAYNLMNMMVAFREKIK*
+
+>NODE_2#PROKKA_00141
+MNIEAFYSLSYGLYIIGTASKGKKNGYVANTAFQVTASPEQIAISCNKDNLSEQMIDESG
+YFSLSVLEKDASKEIINRFGYKSGKTLDKFEGTKYFETNNGIPVVTEECVAWFECKVEQK
+VDVGTHIIFIGRVLNGEYLDENKESLTYTYYRQVRHGLSPKNSPTYVDKSLLPEKEKKEE
+KAEETPAEKPKGKSMQKWECIVCGHIYDPAVGDPEQNIPPGTAFEDLPDDWVCPDCGAEK
+EDFEPIG*
+
+>NODE_2#PROKKA_00118
+VKWDDNWALKLLIQNISLQAIFYQPTISFNLGNKFGVGAGLVYATGNVKMNSALNYSGNS
+GFNLNGKTHNFGFNVGVHYKISDQWSLGATYRSEIKMNVKNGNAAFFVPGSLSSIIPPSN
+HFSASLPLPANFDFGVAYQATKKLLLAAELDWVRWSVYDSLSFHFATNPQLLNNSSPKLY
+KDQWIPRIGAQYQVSKKLMVRAGAYYELSPANVSGYYKTNTVVPGIGINYHF*
+
+>NODE_10#PROKKA_00002
+MGRYILKRLWHTVYVVVGISVIAFFFIHLSGDPVMLMLPADASHQEIEELRQQLGFNDPL
+YVQYWRFATKAVQGDFGESLYYHVPAMELILERLPASLELALAAMAIALVVAIPLGILSA
+VKRGSFIDLGSMLGALFGLSMPHFWLGIMLILLFSVKLGWLPTSGRGGWEHLIMPSLALG
+MSLMAMFARLTRSVMLEVLGQDYVRTARAKGLKERLVIGKHALKNALIPLVTVAGMQFGF
+LIGGTVIIETVFAWPGVGRLVVQAIFNRDYPLVQATVLVLAVLFVLVNLLVDLLYVYLDP
+QISYLEEK*
+
+>NODE_9#PROKKA_00313
+MHLVKKYANRKLYDTTDKQYITMEKLAELIKSGSEVMIIDNETGDDLTAQVVSQLLAREK
+NEDDTALPSSVLMQMLRKGRGTLFGYGKKYISLWQSAVLMSRDENEKLINTLVKDKELSE
+TEGRTLKKEITAYTNGLKTWIRENIDQRVNEALNMMNLASKEQVKELIDQVESLSLKVQS
+LEREIRRKN*
+
+>NODE_7#PROKKA_00278
+VNVLRKSFVVAVVLLSFGASAAVAQTTVAASVYGAFRSSTRTGGISNFTVENPSNAAGFL
+LELRHISNPLMGYELTYSYHRANEAYSNTLKVLCPISPGGSCPEQITTAGVSANAQEVTG
+DWVVSFPLANLKPFVLVGGGVIVTSPATGSVTATITDFDPVTNMMSQTTSSMPTQTQTKG
+VFQYGAGLDWTVLPHIGLRFQYRGNVYKAANLTKVFTSTDKFTQTAEPVVGVFFRF*
+
+>NODE_3#PROKKA_00158
+MLSRAIMAPMDLVLDTAEAQRMALFFDHILIWKLSRRTFNKEDNQRYSSELRYLRERGVA
+LLCGLDIPNLISFGRADGTTWNPMEEMKKDCDLLLPFQVGTGVPDQAENEAHADRLIRHL
+SSRLMYNDKPVVAHAEAVNLNTQGNELNALEITINNIPMPPENIPWEDLIQFRNEEETVA
+KLRALRIWLKDRSSAGQSPREIQEELEHLLYEYRKYMEIQHKKFRQGILSTLISSTPEIV
+ASVATLNFGAAIKSVFDIKGRYLGLSEAELSAPGREVSYIAKARDFLTS*
+
+>NODE_11#PROKKA_00020
+MKLVVFLKQVPGVTEIPWDPASGHLRREKAPGMMNPACRHALEAALILKEQHGGELTAIS
+MGPPAAEEILREALALGADRAVLLSDPRLAGADTPATSYTLSLAVRAVCPDCDLLLLGNQ
+TSDSETGQVGPHLAEELDLPSAINVEELELDGEVLRVKRLCDNFLETLEMDLPALVTINT
+QGHPPRQVPLGGVEDAFSRGEFLVLNAEDLKADLARVGMTGSAGRIVKVYPAGGERKGEL
+IKGAPKRCVLELLERHGDLLGGYLRKDLGGGR*
+
+>NODE_13#PROKKA_00038
+MELTNDEREFFALVNRASLLNPFSDERNDVDLKLAGLPSAAPGTGRVKKAIQSVNERIRQ
+LETDGRADISQYTGRDRELVEKAFLFELFYRFRKQFDELIESQIASDDVPARIPFYNDAF
+SAMQKRGFTEEDFRRYFALAFQIRRAFYFIGRSLVGNSASMKSLRLNLWNNVFTHNMDLY
+DRYLWNRMEDYSTLILGETGTGKGAAALAIGRSGFIPLKKKSFEESFTRSFISLNLSQFP
+ETLIESALFGHKKGAFTGAIENYQGIFEQCSPYGAILLDEIGEVSKPIQIKLLQVIQDRV
+FTPVGSQTRSRFNGRVIAATNRPLETLRGKGFFRDDFYYRLCSDIIVVPPLRQRVQEDPT
+ELDVLLDFTINRLVGRSSPELVQIVREVIDRHLGNDYPWPGNVRELEQCVRRVLLKGIYT
+GDAAVADIDLCRSLTTGIEQGNIDANSLTSGYCYLLYQRHRTFEEVARRTGLDRRTVKKY
+IQDWTSSHSTDNPPETDIPG*
+
+>NODE_1#PROKKA_00055
+MEISVSEFLKPRIAGLTELGENRTRIVLEPLERGFGYTLGNSLRRVLLSSMPGAAVVEAE
+IDGVLHEYTAIDGVQEDVVEILLNLKLLAIRMHAREEATLTLNATGAGVVTAGDIQVDHD
+VEIVNKDLVIAHLAKNGKLSVRLKVMRGRGYMPVVKRYADESQGRKIGKLKLDATFTPIR
+RVAYYVEAARVEQRTDLDKLILDIETNGTIGAEEALRRAAGILTDQLSVFADLSSVSSHT
+PTESRSVKPILLKPVEELELTVRSSNALKAERIRFVGDLVQKSEDELLKTPNLGRKSLTE
+IKDVLARHELALGMKLEDWPPAALAERRAS*
+
+>NODE_10#PROKKA_00007
+LALHTMAYLAAHPGRLISNRVIARDLGVSAAHLSKVLQRLARAGLLESLRGPTGGFRLGR
+PAGEISLMEVYEAIDGKFQPSSCLLGRPVCRGGKCVLGELGRNLERQTREYLLNTKLSEF
+EDFMCFEEGN*
+
+>NODE_2#PROKKA_00147
+MDAGEEKASPKKTILIAEDDETSFFFLKFVLAKENVNILYAQSGQEAVDICEAHPEIDLI
+LMDIKMAGMSGIEATQLIKKRNPRVPVIAQTAFALSSDKENILKAGCDDYITKPIRKEEL
+LEKVNFFLYSKKES*
+
+>NODE_1#PROKKA_00058
+MNPYERYLLPWLIDAVCALPAAARERAKIVPRARGEVLEIGIGTGHNLPYYAPRRVAGVT
+GIDPGVLRRRIMRRAHAAGIEVKLLSLSAESIPAEDASFDTLVSTFTLCSIPDVERALAE
+MRRVLKPTGRLLYLEHGTAPDPRVRRWQDRLTPWWKPLAGGCHLNRDIPRLITGAGFDIV
+EQHSEYIRGPRILSYVFRGEAQPIAVAGSK*
+
+>NODE_3#PROKKA_00190
+MSVKLGIVMDPIGAIHYKKDTSLAMLLAAQRRGWELHYMEMQDLYLRDGEPRARTQALTV
+AANPDDWYSLGEPSDRALASLDVILMRKDPPVDKEFLVTTWMLEAAERLGTLVVNPPQAL
+RDCNEKLFATWFPQCTPPLVVSRDAARLRAFHAEHGDVVLKPLDEMGGRSIFRVREDGDN
+LGVIIETLTKDGSHQIMAQKYLPEITQGDKRILLVDGEPVPYALARIPSQGEHRGNLAAG
+GRGEGRLLTDRDRWIVEQVQPMVREKGLLFVGLDVIGDYLTEINVTSPTCVRELDREYDL
+DISDQLMQVIADRLARR*
+
diff -r 000000000000 -r 68a3648c7d91 de_prokka/tbl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/de_prokka/tbl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,6309 @@
+##gff-version 3
+##sequence-region NODE_10_length_13322_cov_17.9253_ID_19 1 13322
+##sequence-region NODE_11_length_12385_cov_59.906_ID_21 1 12385
+##sequence-region NODE_12_length_10380_cov_58.6117_ID_23 1 10380
+##sequence-region NODE_13_length_9239_cov_583.686_ID_25 1 9239
+##sequence-region NODE_17_length_5536_cov_76.8441_ID_33 1 5536
+##sequence-region NODE_1_length_50014_cov_374.697_ID_1 1 50014
+##sequence-region NODE_21_length_3078_cov_41.6478_ID_41 1 3078
+##sequence-region NODE_22_length_2891_cov_11.4392_ID_43 1 2891
+##sequence-region NODE_25_length_2759_cov_91.0869_ID_49 1 2759
+##sequence-region NODE_29_length_2081_cov_1172.16_ID_57 1 2081
+##sequence-region NODE_2_length_41759_cov_213.726_ID_3 1 41759
+##sequence-region NODE_39_length_1472_cov_66.0355_ID_77 1 1472
+##sequence-region NODE_3_length_39215_cov_155.142_ID_5 1 39215
+##sequence-region NODE_42_length_1523_cov_23.4108_ID_83 1 1523
+##sequence-region NODE_4_length_32829_cov_185.347_ID_7 1 32829
+##sequence-region NODE_50_length_1320_cov_1878.61_ID_99 1 1320
+##sequence-region NODE_5_length_30845_cov_61.6996_ID_9 1 30845
+##sequence-region NODE_6_length_29555_cov_90.739_ID_11 1 29555
+##sequence-region NODE_7_length_23944_cov_113.632_ID_13 1 23944
+##sequence-region NODE_8_length_21143_cov_115.55_ID_15 1 21143
+##sequence-region NODE_9_length_20531_cov_182.121_ID_17 1 20531
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	51	356	.	+	0	ID=PROKKA_00001;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00001;product=hypothetical protein
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	865	1791	.	-	0	ID=PROKKA_00002;gene=gsiC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P75798;locus_tag=PROKKA_00002;product=Glutathione transport system permease protein GsiC
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	1853	3352	.	-	0	ID=PROKKA_00003;gene=hbpA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P33950;locus_tag=PROKKA_00003;product=Heme-binding protein A precursor
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	3401	4405	.	-	0	ID=PROKKA_00004;gene=oppF;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P24137;locus_tag=PROKKA_00004;product=Oligopeptide transport ATP-binding protein OppF
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	4398	5318	.	-	0	ID=PROKKA_00005;gene=oppD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P24136;locus_tag=PROKKA_00005;product=Oligopeptide transport ATP-binding protein OppD
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	5673	7919	.	-	0	ID=PROKKA_00006;eC_number=3.6.4.-;gene=priA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P17888;locus_tag=PROKKA_00006;product=Primosomal protein N'
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	8063	8455	.	+	0	ID=PROKKA_00007;gene=iscR;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AGK8;locus_tag=PROKKA_00007;product=HTH-type transcriptional regulator IscR
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	8455	9315	.	+	0	ID=PROKKA_00008;eC_number=1.8.1.-;gene=asrC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A1Y2;locus_tag=PROKKA_00008;product=Anaerobic sulfite reductase subunit C
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	9345	10373	.	+	0	ID=PROKKA_00009;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00009;product=hypothetical protein
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	10482	11309	.	+	0	ID=PROKKA_00010;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK09894;locus_tag=PROKKA_00010;product=diguanylate cyclase
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	11401	12543	.	+	0	ID=PROKKA_00011;gene=mlaE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P64606;locus_tag=PROKKA_00011;product=putative phospholipid ABC transporter permease protein MlaE
+NODE_10_length_13322_cov_17.9253_ID_19	Prodigal:2.60	CDS	12543	13280	.	+	0	ID=PROKKA_00012;gene=artM;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P54537;locus_tag=PROKKA_00012;product=Arginine transport ATP-binding protein ArtM
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	92	748	.	+	0	ID=PROKKA_00013;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00013;product=hypothetical protein
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	821	1477	.	-	0	ID=PROKKA_00014;eC_number=2.7.4.9;gene=tmk;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9HZN8;locus_tag=PROKKA_00014;product=Thymidylate kinase
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	1691	3073	.	-	0	ID=PROKKA_00015;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF04616.8;locus_tag=PROKKA_00015;product=Glycosyl hydrolases family 43
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	3339	3641	.	+	0	ID=PROKKA_00016;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00016;product=hypothetical protein
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	3860	6106	.	+	0	ID=PROKKA_00017;gene=flgE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A1J1;locus_tag=PROKKA_00017;product=Flagellar hook protein FlgE
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	6213	7121	.	+	0	ID=PROKKA_00018;eC_number=3.5.2.6;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P52700;locus_tag=PROKKA_00018;product=Metallo-beta-lactamase L1 precursor
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	7197	8345	.	+	0	ID=PROKKA_00019;eC_number=1.3.99.-;gene=acdA_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45867;locus_tag=PROKKA_00019;product=Acyl-CoA dehydrogenase
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	8374	9192	.	+	0	ID=PROKKA_00020;gene=acrB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:G3KIM7;locus_tag=PROKKA_00020;product=Acryloyl-CoA reductase electron transfer subunit gamma
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	9189	10205	.	+	0	ID=PROKKA_00021;gene=acrA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:G3KIM6;locus_tag=PROKKA_00021;product=Acryloyl-CoA reductase electron transfer subunit beta
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	10278	10790	.	-	0	ID=PROKKA_00022;eC_number=5.3.3.2;gene=idi;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P26173;locus_tag=PROKKA_00022;product=Isopentenyl-diphosphate Delta-isomerase
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	10787	11119	.	-	0	ID=PROKKA_00023;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00023;product=hypothetical protein
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	11233	12027	.	+	0	ID=PROKKA_00024;eC_number=3.8.1.7;gene=fcbB2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9LCU3;locus_tag=PROKKA_00024;product=4-chlorobenzoyl coenzyme A dehalogenase-2
+NODE_11_length_12385_cov_59.906_ID_21	Prodigal:2.60	CDS	12140	12319	.	+	0	ID=PROKKA_00025;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00025;product=hypothetical protein
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	274	513	.	-	0	ID=PROKKA_00026;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00026;product=hypothetical protein
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	510	977	.	-	0	ID=PROKKA_00027;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00027;product=hypothetical protein
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	987	1460	.	-	0	ID=PROKKA_00028;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00028;product=hypothetical protein
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	1514	5431	.	+	0	ID=PROKKA_00029;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00029;product=hypothetical protein
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	5657	6466	.	+	0	ID=PROKKA_00030;eC_number=4.1.2.-;gene=griI;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:A0JC77;locus_tag=PROKKA_00030;product=2-amino-4%2C5-dihydroxy-6-one-heptanoic acid-7-phosphate synthase
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	6537	7886	.	-	0	ID=PROKKA_00031;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF03972.8;locus_tag=PROKKA_00031;product=MmgE/PrpD family protein
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	7883	9058	.	-	0	ID=PROKKA_00032;gene=yiaO;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P37676;locus_tag=PROKKA_00032;product=2%2C3-diketo-L-gulonate-binding periplasmic protein YiaO precursor
+NODE_12_length_10380_cov_58.6117_ID_23	Prodigal:2.60	CDS	9065	10285	.	-	0	ID=PROKKA_00033;eC_number=1.4.1.18;gene=lysDH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9AJC6;locus_tag=PROKKA_00033;product=Lysine 6-dehydrogenase
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00034;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00034;product=hypothetical protein
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	926	1183	.	-	0	ID=PROKKA_00035;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00035;product=hypothetical protein
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	1234	2226	.	-	0	ID=PROKKA_00036;eC_number=1.1.1.95;gene=serA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A544;locus_tag=PROKKA_00036;product=D-3-phosphoglycerate dehydrogenase
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	2465	3550	.	+	0	ID=PROKKA_00037;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P00198;locus_tag=PROKKA_00037;product=Ferredoxin
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	3589	5091	.	+	0	ID=PROKKA_00038;gene=nifA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P03027;locus_tag=PROKKA_00038;product=Nif-specific regulatory protein
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	5369	5482	.	+	0	ID=PROKKA_00039;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00039;product=hypothetical protein
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	5567	7126	.	-	0	ID=PROKKA_00040;gene=fhlA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0CL46;locus_tag=PROKKA_00040;product=Formate hydrogenlyase transcriptional activator
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	7397	7984	.	+	0	ID=PROKKA_00041;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00041;product=hypothetical protein
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	8057	8314	.	+	0	ID=PROKKA_00042;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00042;product=hypothetical protein
+NODE_13_length_9239_cov_583.686_ID_25	Prodigal:2.60	CDS	8407	8508	.	-	0	ID=PROKKA_00043;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00043;product=hypothetical protein
+NODE_17_length_5536_cov_76.8441_ID_33	Prodigal:2.60	CDS	179	964	.	-	0	ID=PROKKA_00044;eC_number=3.1.1.85;gene=bioH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8GHL1;locus_tag=PROKKA_00044;product=Pimeloyl-[acyl-carrier protein] methyl ester esterase
+NODE_17_length_5536_cov_76.8441_ID_33	Prodigal:2.60	CDS	1107	2195	.	+	0	ID=PROKKA_00045;gene=pipB2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8ZMM8;locus_tag=PROKKA_00045;product=Secreted effector protein pipB2
+NODE_17_length_5536_cov_76.8441_ID_33	Prodigal:2.60	CDS	2298	3593	.	+	0	ID=PROKKA_00046;eC_number=3.7.1.19;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q93NG6;locus_tag=PROKKA_00046;product=2%2C6-dihydropseudooxynicotine hydrolase
+NODE_17_length_5536_cov_76.8441_ID_33	Prodigal:2.60	CDS	3695	5413	.	-	0	ID=PROKKA_00047;eC_number=6.1.1.10;gene=metG;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P23395;locus_tag=PROKKA_00047;product=Methionine--tRNA ligase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00048;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00048;product=hypothetical protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	926	1183	.	-	0	ID=PROKKA_00049;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00049;product=hypothetical protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	1278	2528	.	+	0	ID=PROKKA_00050;gene=secY;inference=ab initio prediction:Prodigal:2.60,protein motif:HAMAP:MF_01465;locus_tag=PROKKA_00050;product=Protein translocase subunit SecY
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	2542	2655	.	+	0	ID=PROKKA_00051;gene=rpmJ;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A7Q6;locus_tag=PROKKA_00051;product=50S ribosomal protein L36
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	2738	3097	.	+	0	ID=PROKKA_00052;gene=rpsM;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A7S9;locus_tag=PROKKA_00052;product=30S ribosomal protein S13
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	3121	3510	.	+	0	ID=PROKKA_00053;gene=rpsK;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A7R9;locus_tag=PROKKA_00053;product=30S ribosomal protein S11
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	3529	4155	.	+	0	ID=PROKKA_00054;gene=rpsD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A7V8;locus_tag=PROKKA_00054;product=30S ribosomal protein S4
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	4174	5166	.	+	0	ID=PROKKA_00055;eC_number=2.7.7.6;gene=rpoA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A0Y1;locus_tag=PROKKA_00055;product=DNA-directed RNA polymerase subunit alpha
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	5180	5560	.	+	0	ID=PROKKA_00056;gene=rplQ;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AG44;locus_tag=PROKKA_00056;product=50S ribosomal protein L17
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	5568	7001	.	+	0	ID=PROKKA_00057;eC_number=1.8.1.4;gene=lpdA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A9P0;locus_tag=PROKKA_00057;product=Dihydrolipoyl dehydrogenase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	6998	7630	.	+	0	ID=PROKKA_00058;eC_number=2.1.1.-;gene=ycgJ;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O31474;locus_tag=PROKKA_00058;product=putative methyltransferase YcgJ
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	7667	7957	.	-	0	ID=PROKKA_00059;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00059;product=hypothetical protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	8151	8462	.	-	0	ID=PROKKA_00060;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00939.13;locus_tag=PROKKA_00060;product=Sodium:sulfate symporter transmembrane region
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	8690	9526	.	-	0	ID=PROKKA_00061;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00061;product=hypothetical protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	9601	10893	.	-	0	ID=PROKKA_00062;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF07992.8;locus_tag=PROKKA_00062;product=Pyridine nucleotide-disulphide oxidoreductase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	11782	13551	.	-	0	ID=PROKKA_00063;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF03600.10;locus_tag=PROKKA_00063;product=Citrate transporter
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	13548	16400	.	-	0	ID=PROKKA_00064;gene=uvrA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A698;locus_tag=PROKKA_00064;product=UvrABC system protein A
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	16503	18152	.	+	0	ID=PROKKA_00065;gene=yveA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O07002;locus_tag=PROKKA_00065;product=Aspartate-proton symporter
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	18374	21304	.	+	0	ID=PROKKA_00066;eC_number=3.1.4.52;gene=gmr;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P77334;locus_tag=PROKKA_00066;product=Cyclic di-GMP phosphodiesterase Gmr
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	21644	23653	.	+	0	ID=PROKKA_00067;eC_number=2.2.1.1;gene=tktA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P27302;locus_tag=PROKKA_00067;product=Transketolase 1
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	23714	24724	.	+	0	ID=PROKKA_00068;eC_number=1.2.1.12;gene=gap;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P00362;locus_tag=PROKKA_00068;product=Glyceraldehyde-3-phosphate dehydrogenase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	24728	25909	.	+	0	ID=PROKKA_00069;eC_number=2.7.2.3;gene=pgk;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q3K5F2;locus_tag=PROKKA_00069;product=Phosphoglycerate kinase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	25902	27365	.	+	0	ID=PROKKA_00070;eC_number=2.7.1.40;gene=pykA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P21599;locus_tag=PROKKA_00070;product=Pyruvate kinase II
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	27365	28957	.	+	0	ID=PROKKA_00071;gene=fdhC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:M1V1V5;locus_tag=PROKKA_00071;product=Fructose dehydrogenase cytochrome subunit precursor
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	28959	30074	.	+	0	ID=PROKKA_00072;eC_number=1.10.3.10;gene=cydB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0ABK2;locus_tag=PROKKA_00072;product=Cytochrome bd-I ubiquinol oxidase subunit 2
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	30088	32715	.	+	0	ID=PROKKA_00073;eC_number=3.5.1.97;gene=quiP;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9I4U2;locus_tag=PROKKA_00073;product=Acyl-homoserine lactone acylase QuiP precursor
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	32636	33370	.	-	0	ID=PROKKA_00074;eC_number=3.6.-.-;gene=soj_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q72H90;locus_tag=PROKKA_00074;product=Chromosome-partitioning ATPase Soj
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	33526	34614	.	+	0	ID=PROKKA_00075;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01734.1;locus_tag=PROKKA_00075;product=Patatin-like phospholipase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	34623	35519	.	-	0	ID=PROKKA_00076;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK05416;locus_tag=PROKKA_00076;product=glmZ(sRNA)-inactivating NTPase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	35624	35947	.	-	0	ID=PROKKA_00077;gene=hpf;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AFX0;locus_tag=PROKKA_00077;product=Ribosome hibernation promoting factor
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	35952	37367	.	-	0	ID=PROKKA_00078;gene=rpoN;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A171;locus_tag=PROKKA_00078;product=RNA polymerase sigma-54 factor
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	37399	38124	.	-	0	ID=PROKKA_00079;eC_number=3.6.3.-;gene=lptB_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45073;locus_tag=PROKKA_00079;product=Lipopolysaccharide export system ATP-binding protein LptB
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	38121	38651	.	-	0	ID=PROKKA_00080;gene=lptA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45074;locus_tag=PROKKA_00080;product=Lipopolysaccharide export system protein LptA precursor
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	38641	39213	.	-	0	ID=PROKKA_00081;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF06835.7;locus_tag=PROKKA_00081;product=Lipopolysaccharide-assembly%2C LptC-related
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	39210	39713	.	-	0	ID=PROKKA_00082;eC_number=3.1.3.45;gene=kdsC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P67653;locus_tag=PROKKA_00082;product=3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	39710	40687	.	-	0	ID=PROKKA_00083;eC_number=5.3.1.13;gene=kdsD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9HVW0;locus_tag=PROKKA_00083;product=Arabinose 5-phosphate isomerase KdsD
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	40756	40959	.	-	0	ID=PROKKA_00084;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00084;product=hypothetical protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	41007	42266	.	+	0	ID=PROKKA_00085;eC_number=2.5.1.7;gene=murA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q3KHZ4;locus_tag=PROKKA_00085;product=UDP-N-acetylglucosamine 1-carboxyvinyltransferase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	42352	42951	.	+	0	ID=PROKKA_00086;gene=sspA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0ACA3;locus_tag=PROKKA_00086;product=Stringent starvation protein A
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	42962	43285	.	+	0	ID=PROKKA_00087;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45206;locus_tag=PROKKA_00087;note=Stringent starvation protein B homolog;product=hypothetical protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	43712	44371	.	-	0	ID=PROKKA_00088;eC_number=2.3.1.28;gene=cat;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P62577;locus_tag=PROKKA_00088;product=Chloramphenicol acetyltransferase
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	44644	44937	.	+	0	ID=PROKKA_00089;gene=xerD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A0P0;locus_tag=PROKKA_00089;product=Tyrosine recombinase XerD
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	46332	47087	.	+	0	ID=PROKKA_00090;gene=repE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P03856;locus_tag=PROKKA_00090;product=Replication initiation protein
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	47675	48841	.	+	0	ID=PROKKA_00091;eC_number=3.6.-.-;gene=soj_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P37522;locus_tag=PROKKA_00091;product=Sporulation initiation inhibitor protein Soj
+NODE_1_length_50014_cov_374.697_ID_1	Prodigal:2.60	CDS	48841	49812	.	+	0	ID=PROKKA_00092;gene=virB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A247;locus_tag=PROKKA_00092;product=Virulence regulon transcriptional activator VirB
+NODE_21_length_3078_cov_41.6478_ID_41	Prodigal:2.60	CDS	254	2167	.	+	0	ID=PROKKA_00093;gene=htpX;inference=ab initio prediction:Prodigal:2.60,protein motif:HAMAP:MF_00188;locus_tag=PROKKA_00093;product=Protease HtpX
+NODE_21_length_3078_cov_41.6478_ID_41	Prodigal:2.60	CDS	2076	2384	.	-	0	ID=PROKKA_00094;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00094;product=hypothetical protein
+NODE_21_length_3078_cov_41.6478_ID_41	Prodigal:2.60	CDS	2397	2972	.	-	0	ID=PROKKA_00095;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00095;product=hypothetical protein
+NODE_22_length_2891_cov_11.4392_ID_43	Prodigal:2.60	CDS	77	1258	.	-	0	ID=PROKKA_00096;eC_number=1.3.99.32;gene=Acd;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:C3UVB0;locus_tag=PROKKA_00096;product=Glutaryl-CoA dehydrogenase
+NODE_22_length_2891_cov_11.4392_ID_43	Prodigal:2.60	CDS	1319	2467	.	-	0	ID=PROKKA_00097;eC_number=1.3.99.-;gene=mmgC_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45857;locus_tag=PROKKA_00097;product=Acyl-CoA dehydrogenase
+NODE_22_length_2891_cov_11.4392_ID_43	Prodigal:2.60	CDS	2621	2857	.	-	0	ID=PROKKA_00098;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00098;product=hypothetical protein
+NODE_25_length_2759_cov_91.0869_ID_49	Prodigal:2.60	CDS	55	264	.	-	0	ID=PROKKA_00099;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00099;product=hypothetical protein
+NODE_25_length_2759_cov_91.0869_ID_49	Prodigal:2.60	CDS	261	596	.	-	0	ID=PROKKA_00100;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00100;product=hypothetical protein
+NODE_25_length_2759_cov_91.0869_ID_49	Prodigal:2.60	CDS	627	998	.	-	0	ID=PROKKA_00101;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00101;product=hypothetical protein
+NODE_25_length_2759_cov_91.0869_ID_49	Prodigal:2.60	CDS	995	1765	.	-	0	ID=PROKKA_00102;eC_number=2.4.2.10;gene=pyrE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9KVD5;locus_tag=PROKKA_00102;product=Orotate phosphoribosyltransferase
+NODE_25_length_2759_cov_91.0869_ID_49	Prodigal:2.60	CDS	2032	2523	.	+	0	ID=PROKKA_00103;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00103;product=hypothetical protein
+NODE_25_length_2759_cov_91.0869_ID_49	Prodigal:2.60	CDS	2429	2620	.	-	0	ID=PROKKA_00104;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00104;product=hypothetical protein
+NODE_29_length_2081_cov_1172.16_ID_57	Prodigal:2.60	CDS	140	820	.	-	0	ID=PROKKA_00105;gene=cbl;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q47083;locus_tag=PROKKA_00105;product=HTH-type transcriptional regulator cbl
+NODE_29_length_2081_cov_1172.16_ID_57	Prodigal:2.60	CDS	899	1156	.	+	0	ID=PROKKA_00106;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00106;product=hypothetical protein
+NODE_29_length_2081_cov_1172.16_ID_57	Prodigal:2.60	CDS	1249	1350	.	-	0	ID=PROKKA_00107;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00107;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00108;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00108;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	926	1183	.	-	0	ID=PROKKA_00109;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00109;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	1393	2184	.	+	0	ID=PROKKA_00110;eC_number=2.8.1.-;gene=mnmA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q931Q6;locus_tag=PROKKA_00110;product=tRNA-specific 2-thiouridylase MnmA
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	2297	2926	.	+	0	ID=PROKKA_00111;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF07947.8;locus_tag=PROKKA_00111;product=YhhN-like protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	2936	3808	.	+	0	ID=PROKKA_00112;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF12695.1;locus_tag=PROKKA_00112;product=Alpha/beta hydrolase family protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	3830	5428	.	+	0	ID=PROKKA_00113;eC_number=2.3.1.-;gene=lnt;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P23930;locus_tag=PROKKA_00113;product=Apolipoprotein N-acyltransferase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	5438	5989	.	+	0	ID=PROKKA_00114;eC_number=1.-.-.-;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q5XCB9;locus_tag=PROKKA_00114;product=Putative NAD(P)H nitroreductase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	5982	6494	.	+	0	ID=PROKKA_00115;gene=rfaH_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8FBI4;locus_tag=PROKKA_00115;product=Transcription antitermination protein RfaH
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	6555	7112	.	+	0	ID=PROKKA_00116;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF02674.10;locus_tag=PROKKA_00116;product=Colicin V production protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	7109	7630	.	-	0	ID=PROKKA_00117;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00657.1;locus_tag=PROKKA_00117;product=GDSL-like Lipase/Acylhydrolase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	7846	8544	.	-	0	ID=PROKKA_00118;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P80603;locus_tag=PROKKA_00118;product=47 kDa outer membrane protein precursor
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	9843	9995	.	-	0	ID=PROKKA_00119;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00119;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	10338	11813	.	+	0	ID=PROKKA_00120;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01609.15;locus_tag=PROKKA_00120;product=Transposase DDE domain protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	11917	12927	.	-	0	ID=PROKKA_00121;eC_number=2.1.1.44;gene=egtD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:A0R5M8;locus_tag=PROKKA_00121;product=Histidine-specific methyltransferase EgtD
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	12948	14255	.	-	0	ID=PROKKA_00122;eC_number=2.8.1.1;gene=ynjE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P78067;locus_tag=PROKKA_00122;product=Thiosulfate sulfurtransferase YnjE precursor
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	14286	14570	.	-	0	ID=PROKKA_00123;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00123;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	14853	15569	.	-	0	ID=PROKKA_00124;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00124;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	15745	17688	.	-	0	ID=PROKKA_00125;gene=ydaP;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P96591;locus_tag=PROKKA_00125;product=Putative thiamine pyrophosphate-containing protein YdaP
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	17707	18507	.	-	0	ID=PROKKA_00126;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00126;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	18637	19311	.	-	0	ID=PROKKA_00127;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00127;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	19464	19763	.	-	0	ID=PROKKA_00128;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00128;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	20185	20445	.	-	0	ID=PROKKA_00129;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00129;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	20913	21179	.	-	0	ID=PROKKA_00130;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00130;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	21183	21743	.	-	0	ID=PROKKA_00131;gene=ylaC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O07627;locus_tag=PROKKA_00131;product=RNA polymerase sigma factor YlaC
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	21952	23145	.	-	0	ID=PROKKA_00132;gene=pgk/tpi;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P36204;locus_tag=PROKKA_00132;product=Bifunctional PGK/TIM
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	23327	24418	.	+	0	ID=PROKKA_00133;eC_number=2.6.1.88;gene=ybdL;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P77806;locus_tag=PROKKA_00133;product=Methionine aminotransferase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	24430	25224	.	+	0	ID=PROKKA_00134;eC_number=3.5.1.111;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q93NG1;locus_tag=PROKKA_00134;product=2-oxoglutaramate amidase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	25365	25970	.	+	0	ID=PROKKA_00135;eC_number=2.7.7.76;gene=mocA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q46810;locus_tag=PROKKA_00135;product=Molybdenum cofactor cytidylyltransferase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	26176	26649	.	+	0	ID=PROKKA_00136;eC_number=1.8.4.14;gene=msrC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P76270;locus_tag=PROKKA_00136;product=Free methionine-R-sulfoxide reductase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	26995	28020	.	-	0	ID=PROKKA_00137;eC_number=3.5.1.46;gene=nylB';inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P07062;locus_tag=PROKKA_00137;product=6-aminohexanoate-dimer hydrolase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	28380	29045	.	-	0	ID=PROKKA_00138;eC_number=2.1.1.163;gene=ubiE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P67062;locus_tag=PROKKA_00138;product=Demethylmenaquinone methyltransferase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	29296	29580	.	-	0	ID=PROKKA_00139;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01797.10;locus_tag=PROKKA_00139;product=Transposase IS200 like protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	29866	30441	.	-	0	ID=PROKKA_00140;gene=rbr;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9AGG3;locus_tag=PROKKA_00140;product=Rubrerythrin
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	30468	31211	.	-	0	ID=PROKKA_00141;gene=hrb;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9FDN6;locus_tag=PROKKA_00141;product=High molecular weight rubredoxin
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	31492	34632	.	-	0	ID=PROKKA_00142;gene=bepE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8G2M6;locus_tag=PROKKA_00142;product=Efflux pump membrane transporter BepE
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	34663	35616	.	-	0	ID=PROKKA_00143;gene=acrE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P24180;locus_tag=PROKKA_00143;product=Multidrug export protein AcrE precursor
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	35905	36258	.	-	0	ID=PROKKA_00144;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK12275;locus_tag=PROKKA_00144;product=hypothetical protein
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	36421	37767	.	-	0	ID=PROKKA_00145;gene=tolC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q54001;locus_tag=PROKKA_00145;product=Outer membrane protein TolC precursor
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	38142	38885	.	-	0	ID=PROKKA_00146;gene=nixA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q48262;locus_tag=PROKKA_00146;product=High-affinity nickel-transport protein NixA
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	39449	39853	.	+	0	ID=PROKKA_00147;gene=divK;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q7BBW0;locus_tag=PROKKA_00147;product=Polar-differentiation response regulator DivK
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	39994	40536	.	+	0	ID=PROKKA_00148;gene=mntP;inference=ab initio prediction:Prodigal:2.60,protein motif:HAMAP:MF_01521;locus_tag=PROKKA_00148;product=manganese efflux pump MntP
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	40553	41029	.	+	0	ID=PROKKA_00149;eC_number=4.1.2.50;gene=queD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O31676;locus_tag=PROKKA_00149;product=6-carboxy-5%2C6%2C7%2C8-tetrahydropterin synthase
+NODE_2_length_41759_cov_213.726_ID_3	Prodigal:2.60	CDS	41193	41717	.	+	0	ID=PROKKA_00150;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF03544.8;locus_tag=PROKKA_00150;product=Gram-negative bacterial tonB protein
+NODE_39_length_1472_cov_66.0355_ID_77	Prodigal:2.60	CDS	184	1179	.	-	0	ID=PROKKA_00151;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF04468.6;locus_tag=PROKKA_00151;note=PSP1 C-terminal conserved region;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	22	402	.	+	0	ID=PROKKA_00152;eC_number=2.1.1.-;gene=adaA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P19219;locus_tag=PROKKA_00152;product=Bifunctional transcriptional activator/DNA repair enzyme AdaA
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	462	1367	.	+	0	ID=PROKKA_00153;gene=yddG;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P46136;locus_tag=PROKKA_00153;product=Aromatic amino acid exporter YddG
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	1387	1605	.	-	0	ID=PROKKA_00154;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00154;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	1703	2098	.	-	0	ID=PROKKA_00155;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00155;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	2529	3689	.	+	0	ID=PROKKA_00156;eC_number=2.1.1.79;gene=cfa_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A9H7;locus_tag=PROKKA_00156;product=Cyclopropane-fatty-acyl-phospholipid synthase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	3856	4269	.	+	0	ID=PROKKA_00157;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00157;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	4476	5345	.	-	0	ID=PROKKA_00158;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00158;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	5359	5838	.	-	0	ID=PROKKA_00159;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00159;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	6601	6888	.	+	0	ID=PROKKA_00160;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00160;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	6942	8393	.	-	0	ID=PROKKA_00161;eC_number=2.7.13.3;gene=yycG;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q45614;locus_tag=PROKKA_00161;product=Sensor histidine kinase YycG
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	8380	9132	.	-	0	ID=PROKKA_00162;gene=cusR;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0ACZ8;locus_tag=PROKKA_00162;product=Transcriptional regulatory protein CusR
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	9334	10113	.	-	0	ID=PROKKA_00163;eC_number=5.3.1.22;gene=hyi;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P30147;locus_tag=PROKKA_00163;product=Hydroxypyruvate isomerase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	10122	11030	.	-	0	ID=PROKKA_00164;eC_number=1.1.1.60;gene=glxR;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P77161;locus_tag=PROKKA_00164;product=2-hydroxy-3-oxopropionate reductase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	11133	11999	.	-	0	ID=PROKKA_00165;gene=rpoH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AGB3;locus_tag=PROKKA_00165;product=RNA polymerase sigma factor RpoH
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	12280	13257	.	-	0	ID=PROKKA_00166;gene=ftsX;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AC30;locus_tag=PROKKA_00166;product=Cell division protein FtsX
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	13288	13977	.	-	0	ID=PROKKA_00167;gene=ftsE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A9R7;locus_tag=PROKKA_00167;product=Cell division ATP-binding protein FtsE
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	14018	15292	.	-	0	ID=PROKKA_00168;gene=ftsY;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P10121;locus_tag=PROKKA_00168;product=Signal recognition particle receptor FtsY
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	15463	16119	.	+	0	ID=PROKKA_00169;eC_number=2.1.1.171;gene=rsmD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0ADX9;locus_tag=PROKKA_00169;product=Ribosomal RNA small subunit methyltransferase D
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	16283	17215	.	+	0	ID=PROKKA_00170;eC_number=3.1.1.3;gene=lip3;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P24640;locus_tag=PROKKA_00170;product=Lipase 3 precursor
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	17373	18560	.	-	0	ID=PROKKA_00171;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00487.18;locus_tag=PROKKA_00171;product=Fatty acid desaturase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	18737	18829	.	+	0	ID=PROKKA_00172;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00172;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	18845	19657	.	+	0	ID=PROKKA_00173;eC_number=3.2.2.23;gene=mutM;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P05523;locus_tag=PROKKA_00173;product=Formamidopyrimidine-DNA glycosylase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	20002	20370	.	+	0	ID=PROKKA_00174;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00174;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	20450	21187	.	+	0	ID=PROKKA_00175;eC_number=3.1.3.5;gene=yrfG;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P64636;locus_tag=PROKKA_00175;product=GMP/IMP nucleotidase YrfG
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	21284	21697	.	+	0	ID=PROKKA_00176;gene=hslR;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0ACG8;locus_tag=PROKKA_00176;product=Heat shock protein 15
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	21761	22618	.	+	0	ID=PROKKA_00177;gene=hslO;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A6Y5;locus_tag=PROKKA_00177;product=33 kDa chaperonin
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	23057	24595	.	+	0	ID=PROKKA_00178;eC_number=4.1.1.49;gene=pckA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q3KJP4;locus_tag=PROKKA_00178;product=Phosphoenolpyruvate carboxykinase [ATP]
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	24776	26881	.	-	0	ID=PROKKA_00179;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF06808.6;locus_tag=PROKKA_00179;product=DctM-like transporters
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	26992	28029	.	-	0	ID=PROKKA_00180;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00180;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	28105	29163	.	-	0	ID=PROKKA_00181;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00181;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	29400	29696	.	+	0	ID=PROKKA_00182;gene=hup;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A3H0;locus_tag=PROKKA_00182;product=DNA-binding protein HU
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	29965	30213	.	-	0	ID=PROKKA_00183;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00183;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	30339	31634	.	-	0	ID=PROKKA_00184;eC_number=3.5.2.3;gene=pyrC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O66990;locus_tag=PROKKA_00184;product=Dihydroorotase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	31631	32653	.	-	0	ID=PROKKA_00185;eC_number=2.1.3.2;gene=pyrB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P56585;locus_tag=PROKKA_00185;product=Aspartate carbamoyltransferase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	32684	33229	.	-	0	ID=PROKKA_00186;gene=pyrR;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q1I3U3;locus_tag=PROKKA_00186;product=Bifunctional protein PyrR
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	33244	33708	.	-	0	ID=PROKKA_00187;eC_number=3.1.-.-;gene=yqgF;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A8I1;locus_tag=PROKKA_00187;product=Putative Holliday junction resolvase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	33701	34258	.	-	0	ID=PROKKA_00188;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK00228;locus_tag=PROKKA_00188;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	34309	35184	.	-	0	ID=PROKKA_00189;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK10819;locus_tag=PROKKA_00189;product=transport protein TonB
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	35335	36288	.	-	0	ID=PROKKA_00190;eC_number=6.3.2.3;gene=gshB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P04425;locus_tag=PROKKA_00190;product=Glutathione synthetase
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	36849	37244	.	+	0	ID=PROKKA_00191;gene=phoP;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P13792;locus_tag=PROKKA_00191;product=Alkaline phosphatase synthesis transcriptional regulatory protein PhoP
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	37286	37648	.	+	0	ID=PROKKA_00192;gene=pleD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9A5I5;locus_tag=PROKKA_00192;product=Response regulator PleD
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	37680	37982	.	+	0	ID=PROKKA_00193;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01584.13;locus_tag=PROKKA_00193;product=CheW-like domain protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	38033	38290	.	+	0	ID=PROKKA_00194;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00194;product=hypothetical protein
+NODE_3_length_39215_cov_155.142_ID_5	Prodigal:2.60	CDS	38383	38484	.	-	0	ID=PROKKA_00195;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00195;product=hypothetical protein
+NODE_42_length_1523_cov_23.4108_ID_83	Prodigal:2.60	CDS	344	865	.	-	0	ID=PROKKA_00196;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00196;product=hypothetical protein
+NODE_42_length_1523_cov_23.4108_ID_83	Prodigal:2.60	CDS	942	1307	.	-	0	ID=PROKKA_00197;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00665.20;locus_tag=PROKKA_00197;product=Integrase core domain protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00198;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00198;product=hypothetical protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	926	1183	.	-	0	ID=PROKKA_00199;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00199;product=hypothetical protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	1343	1768	.	+	0	ID=PROKKA_00200;gene=livH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AEX7;locus_tag=PROKKA_00200;product=High-affinity branched-chain amino acid transport system permease protein LivH
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	1778	2707	.	+	0	ID=PROKKA_00201;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK11301;locus_tag=PROKKA_00201;product=leucine/isoleucine/valine transporter permease subunit
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	2704	4182	.	+	0	ID=PROKKA_00202;gene=livF_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P22731;locus_tag=PROKKA_00202;product=High-affinity branched-chain amino acid transport ATP-binding protein LivF
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	4172	4288	.	+	0	ID=PROKKA_00203;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00203;product=hypothetical protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	4254	5360	.	+	0	ID=PROKKA_00204;eC_number=1.1.1.1;gene=adhD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O53303;locus_tag=PROKKA_00204;product=Putative alcohol dehydrogenase D
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	5370	6791	.	+	0	ID=PROKKA_00205;eC_number=1.2.1.83;gene=ald;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:H8ZPX2;locus_tag=PROKKA_00205;product=3-succinoylsemialdehyde-pyridine dehydrogenase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	6879	7298	.	-	0	ID=PROKKA_00206;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00206;product=hypothetical protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	7437	9014	.	-	0	ID=PROKKA_00207;eC_number=6.2.1.3;gene=lcfB_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O07610;locus_tag=PROKKA_00207;product=Long-chain-fatty-acid--CoA ligase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	9014	10165	.	-	0	ID=PROKKA_00208;eC_number=1.3.99.-;gene=mmgC_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45857;locus_tag=PROKKA_00208;product=Acyl-CoA dehydrogenase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	10191	11012	.	-	0	ID=PROKKA_00209;gene=pcaR_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q52154;locus_tag=PROKKA_00209;product=Pca regulon regulatory protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	11194	12396	.	+	0	ID=PROKKA_00210;eC_number=2.3.1.174;gene=pcaF;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q43974;locus_tag=PROKKA_00210;product=Beta-ketoadipyl-CoA thiolase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	12488	13657	.	+	0	ID=PROKKA_00211;eC_number=1.3.99.-;gene=acdA_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45867;locus_tag=PROKKA_00211;product=Acyl-CoA dehydrogenase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	13749	15512	.	-	0	ID=PROKKA_00212;eC_number=2.2.1.6;gene=ilvG;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P66946;locus_tag=PROKKA_00212;product=Acetolactate synthase large subunit IlvG
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	15531	16748	.	-	0	ID=PROKKA_00213;eC_number=3.1.1.-;gene=estB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9KX40;locus_tag=PROKKA_00213;product=Esterase EstB
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	16927	18570	.	-	0	ID=PROKKA_00214;eC_number=6.2.1.3;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q5SKN9;locus_tag=PROKKA_00214;product=Long-chain-fatty-acid--CoA ligase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	18600	19049	.	-	0	ID=PROKKA_00215;eC_number=3.1.-.-;gene=ydiI;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P77781;locus_tag=PROKKA_00215;product=Esterase YdiI
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	19150	20052	.	-	0	ID=PROKKA_00216;eC_number=1.1.1.340;gene=ptlF;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q82IY9;locus_tag=PROKKA_00216;product=1-deoxy-11-beta-hydroxypentalenate dehydrogenase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	20210	21127	.	+	0	ID=PROKKA_00217;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK07531;locus_tag=PROKKA_00217;product=bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	21359	22330	.	+	0	ID=PROKKA_00218;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00218;product=hypothetical protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	22582	23400	.	+	0	ID=PROKKA_00219;gene=pcaR_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q52154;locus_tag=PROKKA_00219;product=Pca regulon regulatory protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	23458	24849	.	-	0	ID=PROKKA_00220;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00220;product=hypothetical protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	24962	26632	.	-	0	ID=PROKKA_00221;eC_number=6.2.1.3;gene=lcfB_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O07610;locus_tag=PROKKA_00221;product=Long-chain-fatty-acid--CoA ligase
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	27037	27933	.	-	0	ID=PROKKA_00222;gene=pstA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P07654;locus_tag=PROKKA_00222;product=Phosphate transport system permease protein PstA
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	28016	28972	.	-	0	ID=PROKKA_00223;gene=pstC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0AGH8;locus_tag=PROKKA_00223;product=Phosphate transport system permease protein PstC
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	29060	30142	.	-	0	ID=PROKKA_00224;gene=pstS1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P15712;locus_tag=PROKKA_00224;product=Phosphate-binding protein PstS 1 precursor
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	30554	31879	.	-	0	ID=PROKKA_00225;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01609.15;locus_tag=PROKKA_00225;product=Transposase DDE domain protein
+NODE_4_length_32829_cov_185.347_ID_7	Prodigal:2.60	CDS	32377	32736	.	-	0	ID=PROKKA_00226;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00226;product=hypothetical protein
+NODE_50_length_1320_cov_1878.61_ID_99	Prodigal:2.60	CDS	137	394	.	+	0	ID=PROKKA_00227;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00227;product=hypothetical protein
+NODE_50_length_1320_cov_1878.61_ID_99	Prodigal:2.60	CDS	487	588	.	-	0	ID=PROKKA_00228;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00228;product=hypothetical protein
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	132	797	.	+	0	ID=PROKKA_00229;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF09140.5;locus_tag=PROKKA_00229;product=ATPase MipZ
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	1047	2429	.	+	0	ID=PROKKA_00230;eC_number=3.2.1.179;gene=ugl;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9RC92;locus_tag=PROKKA_00230;product=Unsaturated glucuronyl hydrolase
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	2574	3893	.	-	0	ID=PROKKA_00231;gene=prsE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q7ANN5;locus_tag=PROKKA_00231;product=Type I secretion system membrane fusion protein PrsE
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	3900	6170	.	-	0	ID=PROKKA_00232;gene=apxIB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P26760;locus_tag=PROKKA_00232;product=Toxin RTX-I translocation ATP-binding protein
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	6298	7701	.	-	0	ID=PROKKA_00233;gene=bepC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8G0Y6;locus_tag=PROKKA_00233;product=Outer membrane efflux protein BepC precursor
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	8495	28303	.	+	0	ID=PROKKA_00234;gene=cya;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0DKX7;locus_tag=PROKKA_00234;product=Bifunctional hemolysin/adenylate cyclase precursor
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	28356	29495	.	-	0	ID=PROKKA_00235;eC_number=3.5.1.18;gene=dapE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q99SN6;locus_tag=PROKKA_00235;product=putative succinyl-diaminopimelate desuccinylase
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	29500	30261	.	-	0	ID=PROKKA_00236;gene=livF_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P22731;locus_tag=PROKKA_00236;product=High-affinity branched-chain amino acid transport ATP-binding protein LivF
+NODE_5_length_30845_cov_61.6996_ID_9	Prodigal:2.60	CDS	30282	30755	.	-	0	ID=PROKKA_00237;eC_number=3.6.3.-;gene=lptB_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45073;locus_tag=PROKKA_00237;product=Lipopolysaccharide export system ATP-binding protein LptB
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00238;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00238;product=hypothetical protein
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	926	1183	.	-	0	ID=PROKKA_00239;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00239;product=hypothetical protein
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	1234	1665	.	-	0	ID=PROKKA_00240;eC_number=1.4.1.13;gene=gltB_1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O34399;locus_tag=PROKKA_00240;product=Glutamate synthase [NADPH] small chain
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	1701	6245	.	-	0	ID=PROKKA_00241;eC_number=1.4.7.1;gene=gltB_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P55037;locus_tag=PROKKA_00241;product=Ferredoxin-dependent glutamate synthase 1
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	6766	7992	.	+	0	ID=PROKKA_00242;eC_number=3.1.3.3;gene=serB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:A0QJI1;locus_tag=PROKKA_00242;product=Phosphoserine phosphatase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	8237	9340	.	+	0	ID=PROKKA_00243;eC_number=6.3.4.18;gene=purK;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q7A695;locus_tag=PROKKA_00243;product=N5-carboxyaminoimidazole ribonucleotide synthase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	9325	9816	.	+	0	ID=PROKKA_00244;eC_number=5.4.99.18;gene=purE;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9WYS7;locus_tag=PROKKA_00244;product=N5-carboxyaminoimidazole ribonucleotide mutase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	9839	10951	.	-	0	ID=PROKKA_00245;eC_number=2.1.1.79;gene=cfa_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A9H7;locus_tag=PROKKA_00245;product=Cyclopropane-fatty-acyl-phospholipid synthase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	12207	15476	.	-	0	ID=PROKKA_00246;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9RDE2;locus_tag=PROKKA_00246;note=Tricorn protease homolog 1;product=hypothetical protein
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	15757	16602	.	+	0	ID=PROKKA_00247;eC_number=3.1.3.15;gene=hisK;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O34411;locus_tag=PROKKA_00247;product=Histidinol-phosphatase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	17064	17804	.	+	0	ID=PROKKA_00248;eC_number=2.7.6.1;gene=prs;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A717;locus_tag=PROKKA_00248;product=Ribose-phosphate pyrophosphokinase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	17827	18465	.	+	0	ID=PROKKA_00249;gene=rplY;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q7A7B3;locus_tag=PROKKA_00249;product=50S ribosomal protein L25
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	18727	19290	.	+	0	ID=PROKKA_00250;eC_number=3.1.1.29;gene=pth;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q6YP15;locus_tag=PROKKA_00250;product=Peptidyl-tRNA hydrolase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	19760	20014	.	-	0	ID=PROKKA_00251;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00251;product=hypothetical protein
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	20798	21631	.	+	0	ID=PROKKA_00252;eC_number=2.3.1.180;gene=fabH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O67185;locus_tag=PROKKA_00252;product=3-oxoacyl-[acyl-carrier-protein] synthase 3
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	21788	22663	.	-	0	ID=PROKKA_00253;gene=ccpA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P25144;locus_tag=PROKKA_00253;product=Catabolite control protein A
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	23170	25830	.	+	0	ID=PROKKA_00254;gene=btuB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P06129;locus_tag=PROKKA_00254;product=Vitamin B12 transporter BtuB precursor
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	26077	27687	.	+	0	ID=PROKKA_00255;gene=sglT;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P96169;locus_tag=PROKKA_00255;product=Sodium/glucose cotransporter
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	27696	28892	.	+	0	ID=PROKKA_00256;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF04853.6;locus_tag=PROKKA_00256;product=Plant neutral invertase
+NODE_6_length_29555_cov_90.739_ID_11	Prodigal:2.60	CDS	28910	29488	.	+	0	ID=PROKKA_00257;eC_number=2.7.1.48;gene=udk;inference=ab initio prediction:Prodigal:2.60,protein motif:HAMAP:MF_00551;locus_tag=PROKKA_00257;product=Uridine kinase
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00258;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00258;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	926	1252	.	-	0	ID=PROKKA_00259;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00259;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	1234	1539	.	-	0	ID=PROKKA_00260;gene=engB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9X1H7;locus_tag=PROKKA_00260;product=putative GTP-binding protein EngB
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	1593	2258	.	+	0	ID=PROKKA_00261;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01902.11;locus_tag=PROKKA_00261;product=ATP-binding region
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	2342	3202	.	+	0	ID=PROKKA_00262;eC_number=1.1.1.157;gene=mmgB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P45856;locus_tag=PROKKA_00262;product=putative 3-hydroxybutyryl-CoA dehydrogenase
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	3308	4234	.	+	0	ID=PROKKA_00263;eC_number=3.-.-.-;gene=yycJ;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:C0SP91;locus_tag=PROKKA_00263;product=Putative metallo-hydrolase YycJ
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	4333	4797	.	+	0	ID=PROKKA_00264;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00264;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	4884	5828	.	-	0	ID=PROKKA_00265;eC_number=1.3.1.14;gene=pyrD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P25996;locus_tag=PROKKA_00265;product=Dihydroorotate dehydrogenase B (NAD(+))%2C catalytic subunit
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	6018	6845	.	+	0	ID=PROKKA_00266;eC_number=3.1.3.12;gene=otsB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P31678;locus_tag=PROKKA_00266;product=Trehalose-6-phosphate phosphatase
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	6842	8281	.	+	0	ID=PROKKA_00267;eC_number=2.4.1.-;gene=otsA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:A0R4M9;locus_tag=PROKKA_00267;product=Trehalose-phosphate synthase
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	8386	8730	.	-	0	ID=PROKKA_00268;gene=rsbV;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9WVX8;locus_tag=PROKKA_00268;product=Anti-sigma-B factor antagonist
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	8727	9185	.	-	0	ID=PROKKA_00269;eC_number=2.7.11.1;gene=rsbW;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P17904;locus_tag=PROKKA_00269;product=Serine-protein kinase RsbW
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	9429	10718	.	+	0	ID=PROKKA_00270;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q5SMG8;locus_tag=PROKKA_00270;product=Magnesium transporter MgtE
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	10756	11571	.	-	0	ID=PROKKA_00271;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00271;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	11886	12218	.	+	0	ID=PROKKA_00272;gene=mntH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q99UZ7;locus_tag=PROKKA_00272;product=Divalent metal cation transporter MntH
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	12270	12980	.	-	0	ID=PROKKA_00273;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00273;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	13422	13901	.	+	0	ID=PROKKA_00274;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF08327.5;locus_tag=PROKKA_00274;note=Activator of Hsp90 ATPase homolog 1-like protein;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	13907	14233	.	+	0	ID=PROKKA_00275;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O53478;locus_tag=PROKKA_00275;product=HTH-type transcriptional regulator
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	14336	14578	.	-	0	ID=PROKKA_00276;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00276;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	14727	16028	.	-	0	ID=PROKKA_00277;eC_number=2.5.1.19;gene=aroA1;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9KCA6;locus_tag=PROKKA_00277;product=3-phosphoshikimate 1-carboxyvinyltransferase 1
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	16336	17046	.	+	0	ID=PROKKA_00278;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00278;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	17066	18877	.	-	0	ID=PROKKA_00279;eC_number=3.1.3.3;gene=rsbU;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P40399;locus_tag=PROKKA_00279;product=Phosphoserine phosphatase RsbU
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	19097	19654	.	-	0	ID=PROKKA_00280;eC_number=2.4.2.8;gene=hpt;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P99085;locus_tag=PROKKA_00280;product=Hypoxanthine-guanine phosphoribosyltransferase
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	19780	20622	.	+	0	ID=PROKKA_00281;eC_number=2.4.99.-;gene=lgt;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P60962;locus_tag=PROKKA_00281;product=Prolipoprotein diacylglyceryl transferase
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	20873	21556	.	-	0	ID=PROKKA_00282;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00282;product=hypothetical protein
+NODE_7_length_23944_cov_113.632_ID_13	Prodigal:2.60	CDS	21579	23522	.	+	0	ID=PROKKA_00283;eC_number=2.7.7.7;gene=polA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P00582;locus_tag=PROKKA_00283;product=DNA polymerase I
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	67	519	.	-	0	ID=PROKKA_00284;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00284;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	744	3548	.	+	0	ID=PROKKA_00285;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00285;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	3736	4218	.	+	0	ID=PROKKA_00286;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00286;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	4221	5591	.	+	0	ID=PROKKA_00287;eC_number=3.-.-.-;gene=blh;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8UAA9;locus_tag=PROKKA_00287;product=Beta-lactamase hydrolase-like protein
+NODE_8_length_21143_cov_115.55_ID_15	Aragorn:1.2	tRNA	5694	5770	.	-	0	ID=PROKKA_00288;inference=COORDINATES:profile:Aragorn:1.2;locus_tag=PROKKA_00288;product=tRNA-Arg(ccg)
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	5835	6365	.	-	0	ID=PROKKA_00289;gene=rfaH_2;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q8FBI4;locus_tag=PROKKA_00289;product=Transcription antitermination protein RfaH
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	6377	8167	.	-	0	ID=PROKKA_00290;eC_number=2.7.3.9;gene=ptsI;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P08838;locus_tag=PROKKA_00290;product=Phosphoenolpyruvate-protein phosphotransferase
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	8130	8537	.	-	0	ID=PROKKA_00291;eC_number=2.7.11.-;gene=ptsH;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9EYQ9;locus_tag=PROKKA_00291;product=Phosphocarrier protein HPr
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	8687	8983	.	-	0	ID=PROKKA_00292;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00076.16;locus_tag=PROKKA_00292;product=RNA recognition motif. (a.k.a. RRM%2C RBD%2C or RNP domain)
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	9080	9382	.	-	0	ID=PROKKA_00293;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00076.16;locus_tag=PROKKA_00293;product=RNA recognition motif. (a.k.a. RRM%2C RBD%2C or RNP domain)
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	9477	9779	.	-	0	ID=PROKKA_00294;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF00076.16;locus_tag=PROKKA_00294;product=RNA recognition motif. (a.k.a. RRM%2C RBD%2C or RNP domain)
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	10566	14414	.	+	0	ID=PROKKA_00295;eC_number=3.2.1.1;gene=amyB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P14898;locus_tag=PROKKA_00295;product=Alpha-amylase 2
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	14411	15214	.	+	0	ID=PROKKA_00296;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00296;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	15244	16038	.	-	0	ID=PROKKA_00297;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00297;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	16239	17096	.	+	0	ID=PROKKA_00298;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00298;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	17104	18843	.	+	0	ID=PROKKA_00299;eC_number=2.6.1.85;gene=pabB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P28820;locus_tag=PROKKA_00299;product=Aminodeoxychorismate synthase component 1
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	18983	19120	.	+	0	ID=PROKKA_00300;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00300;product=hypothetical protein
+NODE_8_length_21143_cov_115.55_ID_15	Prodigal:2.60	CDS	19306	21012	.	-	0	ID=PROKKA_00301;eC_number=4.1.1.32;gene=pckG;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9AEM1;locus_tag=PROKKA_00301;product=Phosphoenolpyruvate carboxykinase [GTP]
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	732	833	.	+	0	ID=PROKKA_00302;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00302;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	926	1183	.	-	0	ID=PROKKA_00303;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00303;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	1234	1335	.	-	0	ID=PROKKA_00304;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00304;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	1474	2625	.	-	0	ID=PROKKA_00305;gene=braC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P21175;locus_tag=PROKKA_00305;product=Leucine-%2C isoleucine-%2C valine-%2C threonine-%2C and alanine-binding protein precursor
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	2723	3154	.	-	0	ID=PROKKA_00306;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK11895;locus_tag=PROKKA_00306;product=acetolactate synthase 3 regulatory subunit
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	3194	4231	.	-	0	ID=PROKKA_00307;eC_number=1.2.1.38;gene=argC;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9X2A2;locus_tag=PROKKA_00307;product=N-acetyl-gamma-glutamyl-phosphate reductase
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	4476	5189	.	-	0	ID=PROKKA_00308;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00308;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	5186	6547	.	-	0	ID=PROKKA_00309;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK11788;locus_tag=PROKKA_00309;product=tetratricopeptide repeat protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	6580	7500	.	-	0	ID=PROKKA_00310;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF01734.1;locus_tag=PROKKA_00310;product=Patatin-like phospholipase
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	7519	8913	.	-	0	ID=PROKKA_00311;eC_number=3.4.21.107;gene=mucD;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q4KGQ4;locus_tag=PROKKA_00311;product=putative periplasmic serine endoprotease DegP-like precursor
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	9020	9262	.	+	0	ID=PROKKA_00312;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00312;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	9345	9914	.	-	0	ID=PROKKA_00313;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF07879.5;locus_tag=PROKKA_00313;product=PHB/PHA accumulation regulator DNA-binding domain protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	10479	12176	.	+	0	ID=PROKKA_00314;eC_number=2.3.1.20;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:O06795;locus_tag=PROKKA_00314;product=Putative diacyglycerol O-acyltransferase/MT1809
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	12271	13407	.	-	0	ID=PROKKA_00315;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK10818;locus_tag=PROKKA_00315;product=cell division inhibitor MinD
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	13404	14444	.	-	0	ID=PROKKA_00316;eC_number=3.6.3.16;gene=arsA;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P08690;locus_tag=PROKKA_00316;product=Arsenical pump-driving ATPase
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	14531	15148	.	-	0	ID=PROKKA_00317;inference=ab initio prediction:Prodigal:2.60,protein motif:Pfam:PF07879.5;locus_tag=PROKKA_00317;product=PHB/PHA accumulation regulator DNA-binding domain protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	15353	15904	.	-	0	ID=PROKKA_00318;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00318;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	16373	17275	.	+	0	ID=PROKKA_00319;inference=ab initio prediction:Prodigal:2.60,protein motif:CLUSTERS:PRK10279;locus_tag=PROKKA_00319;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	17361	17648	.	+	0	ID=PROKKA_00320;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00320;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	17663	18685	.	-	0	ID=PROKKA_00321;eC_number=4.2.3.4;gene=aroB;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9KNV2;locus_tag=PROKKA_00321;product=3-dehydroquinate synthase
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	18710	19732	.	-	0	ID=PROKKA_00322;eC_number=2.5.1.54;gene=aroF;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:Q9WYH8;locus_tag=PROKKA_00322;product=Phospho-2-dehydro-3-deoxyheptonate aldolase
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	20103	20210	.	+	0	ID=PROKKA_00323;inference=ab initio prediction:Prodigal:2.60;locus_tag=PROKKA_00323;product=hypothetical protein
+NODE_9_length_20531_cov_182.121_ID_17	Prodigal:2.60	CDS	20207	20464	.	+	0	ID=PROKKA_00324;gene=fadR;inference=ab initio prediction:Prodigal:2.60,similar to AA sequence:UniProtKB:P0A8V6;locus_tag=PROKKA_00324;product=Fatty acid metabolism regulator protein
+##FASTA
+>NODE_10_length_13322_cov_17.9253_ID_19
+GGGCGTCGCGCAAGCCGTCGCCCAGCAGGTTGATGGCCAGGATGGTTAGCATGATGGCCA
+GACCGGGCAGGGTGACCAGCCACCAGGCGTCGGTGATGTATGCGCGTCCCTCGGCCAACA
+TGCGGCCCCAGGTGGGCTGGGGCGGGGGCACCCCCATGCCGAGGAAGGAGAGTCCGCTCT
+CCCAGATGATGATATTGGCCACCCGCACCGTGCCCAGCACCAAAAGCGGCGAGAGGATGT
+TGGGCAGGATGTGGCGGCGGATGATGGTGCGGTTCCGGGTGCCCAGGCTGTGGGCCGCCT
+TGACGAACTCCTTCTCCTTCAGGGCCAGCACGCTGCCGCGCACCGTGCGGGCGTAGGTCA
+CCCAGTCGGAGACGCCCAGCACCAGGATGAGGTTGAAGATGGAGTTGCCCAGCACGGCGA
+TGATGGAGATGGTGAGCAACATGAAGGGATAGGCCATGAACACGTCGGCGATGCGCATGA
+TGATGGAATCGGTGCGCCCGCCGTAGTAGCCCGACAAGAGCCCCAGCACGATGCCCAGGG
+CCTCGGCCACCAGCACCGAGGCGAACCCCACCAGCAGGCTGACCCGGCTGCCGTAGAGTA
+TGCGGGCCAGCACGTCGCGCCCCAGGTTGTCGGTCCCCAAAGGATGCGCCAGGCTGCCGC
+CGGCCTGCCAGGCAGGCGGCGTGAGGCGGGCCATGAGGTCCTGGGCCAGCGGGTCCACCG
+GGTAGTAGAGGGGAAAGGTCAGGCTGATGCCCACGATGAGCGCCAGCATGATCCCCCCCA
+CCACCGCGCTGCGGGAGCGTTTCAGCTCGGTCAGGGTGTCGGCCCATAGGCGCAGGGTGG
+GGACCAGGGCGGCTACGCGCAGAGTCATTTCTCCTCCAGATAGCTGATCTGGGGGTCCAG
+GTAGACGTACAGCAGGTCCACCAACAGGTTGACCAGCACAAACAGCACCGCCAGCACCAG
+CACCGTGGCCTGCACCAGGGGATAGTCGCGGTTGAAGATGGCCTGCACCACCAACCGGCC
+CACCCCCGGCCAGGCAAAGACGGTCTCGATGATCACCGTCCCCCCGATGAGAAAGCCGAA
+CTGCATGCCAGCCACGGTGACCAAGGGGATCAGCGCGTTCTTGAGCGCGTGCTTGCCGAT
+GACCAGGCGTTCCTTGAGCCCCTTGGCCCGGGCGGTGCGCACGTAGTCCTGGCCCAGCAC
+CTCCAGCATCACCGAGCGGGTGAGCCGGGCGAACATGGCCATGAGGCTCATGCCCAGGGC
+CAGCGAGGGCATGATCAGGTGCTCCCAGCCGCCGCGGCCCGAGGTGGGCAGCCAGCCCAG
+CTTCACCGAAAAGAGCAGGATCAACATGATCCCCAGCCAGAAATGCGGCATGGAAAGCCC
+GAACAACGCCCCCAGCATGGAGCCCAGGTCGATGAAGGAGCCGCGTTTCACCGCCGAGAG
+GATCCCCAGCGGGATCGCCACCACCAGGGCGATGGCCATGGCCGCCAGGGCCAGTTCCAG
+GCTGGCTGGCAGACGCTCCAGGATCAGCTCCATGGCCGGCACATGGTAGTAGAGCGACTC
+GCCGAAGTCGCCTTGTACGGCCTTGGTGGCAAATCGCCAGTACTGCACGTAGAGCGGGTC
+GTTGAACCCGAGTTGCTGGCGCAGCTCCTCGATCTCCTGGTGCGAGGCGTCGGCCGGCAG
+CATGAGCATCACCGGATCGCCCGAGAGGTGGATGAAGAAGAAGGCGATCACCGAGATGCC
+CACCACCACGTAGACCGTGTGCCAGAGCCTTTTCAGGATATAGCGTCCCATGCCGCTTCC
+GCCGGGCGGGCCGGGGGGCGAGCCCCCGGCCCGGTACCGGGTCTTGAGGTTGTTACTTGG
+GCTTGGCGGTACGCATGTCCAGGAAGCCGTCGCGACGGCCCTGGTAGGCCACCTGGTTGC
+TCACCGCGAACACCTCGGGGATCACGTAGAGGTAGACCCAGGGCGCGTCGTTGTAGAGCA
+GCCGGTCGATCTTGTGGTAGACCTCGGCCCGTTTCTTGCGGTCCAGGATGGTGCGGCCCA
+GGTCCAAGAGTTTGTCCACCTCGGGGTTCTTGTAGTAGTAGTCGCGCACCTTGGAATTGA
+ACAGCGAGTACATGTAGCGGTCCGGCTCCGGGGCGTCGTCCCACCAGTAGATGTACATGG
+CGTGCTTGCGGGCCTTGTAGCGCTGCCACATCACCGCCCGCTCGTAGGGCTCCAGCCTGA
+CCTTCACACCTACCTTGGCCAGATCGGCCGCGATGGCCTCGGCCTGCTCCTGGATCTGGG
+ACATGTAGGTGGGATAGGCCAGCCGGGTCTGGAAGCCGTTGGGATAGCCAGCCTCGGCCA
+AAAGCTTCTTGGCCTTGGCCGGATCGTAGGGATAGGGCTTGAGGTTGGGGTCGTGCCCGA
+AAGTGCGGGGGCTGATGGGCCCGGCGCAGAGGATGGCCTTGCCGCCAAAGAGCGCCTTGT
+TGATCAGCTCGCGGTTGACGGCGTAGTTCATGGCCTGGCGCACCCGCACGTCATTGAAGG
+GCGGCTTGTAGGTGTTGAGCCCCAGGTAGGGCATCACGCCCATCTGGTTGGTGAGGTAGG
+CCTTGCCCGAGGCCAGGATCCTCTTGCGCTGGTGGATGGACACGCCGCTGATCACGTCGG
+CCTCGCCAGTCAGAAGCGCGGCGATGCGCGAGGCCTCCTCGGGCACGCCCTTGAAGATCA
+CCTTCTTGAAGGCCGGCTTGGGGCCGTAGTACTTGTCGTAGGCGGTGAGCACGATCTCCT
+CGCCGCGCACCCACTTCTCCAGCTTGTAGGGCCCGCAGCCGATGGGGTTGGTGTTGTACT
+TGGCGTCGCCCACCTTCTTGATGTAGCCCGGCGGCACGATGGGCAGGTAGTAGCCCAGGA
+TGTAGAGCCCCGGCGCGTAGGGTTCCTTGGTGGAGATGAGCAGGGTGTAGTCGTCCAGGA
+CCTTCACCTCCTTGAAGGCGCTCAGCTTGCCCTTGTGGGGGTTCTTGATGCTGGGCTTGA
+AGGACCGCTCGAAGGAGAACTTAACCGCCTGGGCGTTGACCGGCTCGCCGTTGTGGAAGG
+TGGCGTCGCGGCGCAGGTGGATCTTCCAGGTCAGGTCGTCCACCTTCTCCCAGCTCTCGG
+CCAACCGCGGCTTGACCGAGGCGTCCTCCTGGGGCGCGAAAAGGGTGTCGTGGATGTTGT
+AGCAGACGCTCATGGTGGTCTGGATGGAACTGGTCATCAGGTCCAGCCCCACCGGCTCGG
+CCTCCTGGATCACCACCAGCACGTCCTTTTTAGCCAGCGCCGGGCCGGCCAGGATGGCCA
+GGCCCAACGCGGCCACGCCCAAGGCCAAACACAGTCTCTTGAATTTTTTCATCTGGTCCC
+TCCTCCTGAGTATTGGTCCTGTGCCGGGCCCGGCCCGGCGTTATCCCCCCTCAACCGTTC
+CGCCCGGGGCGGAGCGAACCTCGTCATACAGGTGGCAGGCCACCAGGTGGCCATCGGCCA
+GCGGCCGCAGCTCCGGGGCCTGGTGCCGGCATATCTCCATGGCCCGGCCGCAGCGGGGAT
+GGAAGTGGCAGCCGGACGGCGGGTCCAGGGGGCTGGGCACGTCGCCCTCCAGGATGATGC
+GCCGGCGGCGGCGCCGGGGATTGGGCACCGGCACCGCCGAGAGCAGGGCCTGGGTATAGG
+GATGCATGGGCCGAGCGTAGAGTTCCTTGACCCCAGCCTGCTCCACGATGCGCCCCAGGT
+ACATCACCGCCACCCGCTGGCTGACGTAGCGGATCACCGCCAGGTCGTGGGAGACGAAGA
+TGTAGGAGAGCCCCAACTGGCGCTGCAACCGGGAGAGCAGATTGAGCACCTGGGCCTGCA
+CCGACACGTCCAGGGCCGATACCGGCTCGTCGCAGATGATCACCTTGGGCCGCAGCACCA
+GGGCCCGGGCCAGGCAGATGCGCTGGCGCTGGCCGCCGGAGAACTCGTGGGGGAAACGCT
+GGGCGTGCTCGGGCAAAAGCCCCACCATGGACAGGCCCTCGGCCACCAGCTCCCGCCGCC
+GCGCCGCCGAAAGCTCCAGGTGATTCAGAAGCGGCTCCTCGACGATCTGGGCCACGGTCA
+TGCGGGGATTCAGCGAGCCGAAGGGGTCCTGGAAGACGATCTGGATGTCGCGGCGCAGCC
+TGCGCAGCTCCTCGCTGCCCGCGGCGGCCAGGTTGCGCCCCTGGAACCAGACCTCGCCGG
+CGGTGGGGTCAATGAGACGCAGCAGGCAGAAGGCGATGGTGGACTTGCCGCAACCGCTCT
+CGCCCACCAGCCCCAGGGTCTGGTTCTCCTCCAGGGTGAAGGAGACCCCGTCCACCGCGT
+GCACCACCCCCTGCCGGCGGCCGAAGAAGCCCTGGCGCACCGGGAAGTGCTTGACCAGCT
+CCTTTACGCGCAGAACCTCAGCCACGATCCACCCTCCAACAGGCCACCCGGTGCCCGGGT
+CGCACCTCCACAAGCTCCGGCTCCTGCCTGGCGCAGCGCTCGTCGGCCAGGTGGCAGCGC
+GGCGCGAAGTTGCAGCCCGGCGGTAGATCCAGCAGGCTGGGTACCACTCCCCTGATCTCG
+TGCAGCTCCTTGTCCGCCAGCTCGGCCTCGGCGCTGGGGATGGCCTCCAATAGACCCCGG
+GTGTAGGGGTGCAGGGGGTGGTCGAACAGCTCCACGGTGGGGGCCTGTTCCACGATGCGT
+CCGGTGTACATCACCGCCAGGCGCTCGGTGGTCTCGGCCACCACCCCCAAATCGTGGGTG
+ATGAGCACCACCGCGGTGCCCAGTTCATCGCGCAACTCCAGGATCAGCTCCAGGATCTGG
+GCCTGGATGGTCACGTCCAGGGCGGTGGTGGGCTCGTCGGCCAAAAGCAGGGCCGGGCGG
+CAGGCCAGGGCCATGGCGATCATCACCCGCTGGCGCATGCCGCCCGAGAGCTGATAGGGG
+TACTCCCTGACCCGCCGCGCCGGGGCCGGTACCCCCACCATCTCCAGCATCTCCACCGCC
+CGGCGCCGGGCCTCGCGGCGCGCCAGGCCCTGGTGCACCCGAAAGACCTCGCCGAGCTGG
+TTGCCGATGGTGAAGACCGGATTCAGGGCGGTCATGGGCTCCTGGAAGATCATGCTGATC
+TGGTTGCCGCGCAGCCGGCGCAGTTCCTCGGGGTCCATCTTCAGCAGGTCGCGCCCCTTG
+AAGCGTATCTGCCCCCCGGCGAAGAAGGCCGGCGGCATGGGCAGAAGACGCAGCACCGAA
+AGCGCCAGGGCGCTCTTGCCGCAGCCGCTCTCACCCACCAGGCCCAGTATCTCGCCCCGG
+CCCACGGTGAGGTCCACACCGTCCACCGCCCGGGCCACGCCCTGGTTGGTCTGGAAACAG
+GTCTTGAGCCCCTTGATCTCCAGGACGGGAGGGGAGGGCTCGGCTTTGGAAACGCCCGCG
+TGACTGATGGCTGTCTCCCCGTTGCTGCTGGTTTTGCTGGAAAGGAGTCCCGCTGTGCCC
+GGCGGCAGGATCCCTGCGGTCGCCGCCGGCAGCCCACCCGAATACGCACGCTTGTGAACA
+TCATACTGTCAAGGGCGTCATATTCCTGTCAAGAATATTTTGCGGCCCGCAACGATTTTC
+GGGCGCATTATTATTTCCAGATAGTGAACCCTCCGCCGGCCGGCGGGGACAAAGAACAAA
+TTCATTCAACTAATTAGGGCCGAGCAGCAACATCAAATCAGGCTCACGGGGTCCACGTCC
+ACCAAAAGCCGCACCCCAGCGGGCAGCGGCGGACTGCGGTGCAACCCCAGGCGCAGGGTG
+CGCCCCGCCGCGGCGGCGGTGGGGGCCTTGAGCAGGATCATCCAGCGGTGGCGGGCCTTG
+GCCCGGGGCAGGGCCGCCGGGGCCGGGCCCAGCACCCGGGCGCCGGGCTCCAGGCGCCGG
+CGGGCCTCCTCCAGCCCGGCGGCCAGGGCCTGGGCCGCCCGCTGGCAGCGCCTGTCGTCC
+ACCGCCTCCAGGCGCAGGGCCACCAGGCGCATGAAAGGCGGATAGCCCAGGGCGCGGCGC
+TCGGCCAGCTCGGTCTGGTAGAACTCGTCGGGGCGCTGGGCCAGAGCGGCGCGCAGAGCG
+TGGTGGTCGGGGTCGTAGGCCTGCACGATGACCCGGCTTTTGCCTCCCTGTCGCCCGGCG
+CGGCCGGCCACCTGGGTGAGCAGGCCGTAGGCCCGCTCGCCGGCCCGGAAGTCGGGCAGG
+GCCAGGGCCTGGTCGGCCGAGAGCACCCCCACCAGGCCGATGCCGGGGAAGTCGTGCCCC
+TTGGTGATCATCTGGGTGCCCACCACCACCTCCACCCGCCGCTCGGCGATGGCGCGCAGA
+AGTTCGCCCAGCCGGCGGGGGTCGCCGGCGGTGTCGCGGTCCAGGCGGGCGATGCGCGCA
+CCGGGCAGGAGCTCGCCCAGCTTCTGGGCCACGGCCTCGGTGCCCAGGCCCAGGGGCCGC
+AGCTTCTCCTCCCCGGCGCCGCAGGCGGGGCAGGTGCGGGGCCGCGGCCGCTGGTGGCCG
+CAGACGTGGCAGACGAGCCGGTCGCTGCCCTGGTGCAGGGTGAGGCTCACCGCGCAGGCC
+GGGCAGCCCACGGTCTGGCCGCAGGCGGTGCAGAGATAGGCCGGGGCGAAGCCACGGCGG
+TTCAGGAAAAGGATGGCCTGCTCGCCGGCCTCGAGGGTCTGCTCCAGGGCCGCCAGCAGA
+CGCCGGCTGAGGAAGCCCCCCACCAAGCGCCCCTCCCGACGCAGGTCCACCAGCTCCATG
+CGCGGCAGGGGGGCCTCGCGCACTCGGCGCGGCAGGCGCAGGCAGACGGTGTTCCCCTCC
+TGGGCGCGGTGGTAGGTGGTCACCGCCGGCGTGGCGGTGCCCAGCACCACCGGGCAGTCC
+TGCTCGCGGCCCCGCAAAAGCGCCAGGTCCCGGGCGTGGTAGCGGAAGCGGTCCTCCTGC
+TTGTAGGCCTCGTCCTGCTCCTCGTCCACGCAGATCACCCCCGGCTCCCGCAGGGGCGCA
+AACACCGCCGAGCGCGCCCCCACCACCACCCGGGCCCGGCCCCGGGCGATGGCCAGCCAC
+TGGCCGCGCCGCGCCGCGGGGCTGAGCCCCGAGTGCAGCACCGCCACCTGCCCGGCGCCG
+AAGCGCTGGCGCAAAAGCCCCTCCAGGCGCAGGCACAAGCCTATCTCGGGCGTGAGCAGG
+AGCGCCGTGCGCCCGGCCTCCAGGGCGGCCTTGACGCAGGCCATATACAGCTCGGTCTTG
+CCCGAGCCGGTGACCCCGTGCAGCAGAAAGGACTTGAAGCCCCCGGAGTGCACCGCGGGC
+AGCAGCTCATCCAGCGCCCGCTGCTGGTCCGGGGTGTAGTGCTCGGGCTCGGGCTCGGGC
+AGGAGGGGACGGCCCAGCAGGTCCTTGACCAGGGGGCGGTGGCTGATGGTCACCCAGCCG
+CGTTTCTCCAGGTCGCGGCACAGGGCCGCGGCGCGGGGAAACTCCTCCCGCAGCTCGGGC
+AGGGGCAGAGGCCCCCGGGCCTTGAGCCGCCGCAGGATGCGCGCGGCCTGGCTCTCGGGC
+CGGGGCAGGCGCGAGTCCTCCCCCCGGCGCCAGCTCACCACCGCCACCTGCTGGGTCTTG
+GGGGCCAGGGCCTTGGCCGGCCGGGCCGAGCCCATCCCCGCCGGCAGGCACCAGGCCAGC
+ACCTGCCCCAAGGGGACGTGGTAGTAGGCCGCGGCGCGCTGGAAAAAGGGCAGCAGCTCG
+GGCGGCCACACCTGGGGGCCCTTGCCGTCCTCCAGCACGTCCAGCACCGGCTTGAGCGCG
+TCCTGCCCCCCTCCTGCCGCCAGGGGTTCACCCAGGGCGAAGCCCAGGCGGGCGCCTCCC
+CGAAGCGGCACCAGCAGCCGGGACAAGGGCTTCACCAGAGGCGCCAGCTCCGCGGGCACC
+GCGTAGGTCAGCGGCTGCCACAGGGGCGCGGCCAGGGCTACGTCCACCATGAGGGTCATG
+GCTGTAAAGGGTAGCAGAAAGGGCGGGGTGCAGAAAGCGGGGGATTGTTATTGACTGGGC
+AGGGTATTTAGTTATAATGGTACTAAAATACTTATTAGGCAAGAACATGTCACATTGGTT
+TAAGATATCAGAGGCATCCTCCTTGGCCCTGCACACCATGGCCTACCTGGCCGCCCACCC
+GGGACGGCTCATCTCCAACCGGGTGATCGCCAGGGATCTGGGGGTCTCGGCGGCCCATCT
+CTCCAAGGTCCTCCAGCGGCTGGCCCGCGCCGGGCTGCTGGAGTCCCTGCGCGGGCCCAC
+GGGAGGGTTCCGCCTGGGGCGCCCGGCGGGCGAGATAAGCCTAATGGAGGTCTACGAGGC
+CATCGACGGCAAGTTCCAACCTTCTTCCTGCCTGCTGGGACGGCCGGTCTGCCGGGGCGG
+CAAATGCGTGCTGGGCGAACTGGGGCGCAACTTGGAGCGCCAGACGCGGGAATATCTTCT
+GAATACCAAGCTGTCGGAGTTCGAGGACTTCATGTGTTTCGAGGAGGGAAACTGATGCCC
+CTGGGCAAAGGGCGTGGCGGCGCGCTGCCCTGGGACCCCCGCGCCGAGGCGGCCCTGGGG
+CGGGTGCCCTTTTTCGTGCGTTCGCTGGTGCGGCGCAAGGTGGAAGAGCGGGTGGCCGAG
+GCCGGTGGCCGGCGGGTGGGCCTGGAGGACTTCCAGGAGGCCGAGGCGGCCTTCCGGGCG
+GTGCGCGCCGGCAAGAGCCAAAAGGAACTCGAGGCCATGCTGCCGGCGGAGAACCGCCCC
+GGTGTGGAGATGGTGGTGGTCCAGGCCTGCCGCAGCCGGTTGAGCAACTGTCCCAACCCG
+CTCATCGACACCCAGAAGTGGCTGGAGAGGGTGCAGGCCTGGGTGGAGGAGCTGGATCTC
+TCCGAGCGCCTGCGCCGGCGGGTGGCGGATGACAAGATACTCTTTCACCACAAGCTCAAG
+ATAGCCATCGCCGGCTGCCCCAACGGCTGCTCGCGCCCCCAGATCGCGGACCTGGCCCTG
+GTGGGCATGACCCGGCCGCGGCTGGTGGAGCCGGAGGTCTGCACCGCCTGCGGGGCCTGC
+GCCGAGGCCTGCCCCGACGGGGCCGTGAGCCAGGACGACGGCCCGCCGGAGTTCCACCGC
+GAGCTCTGCCAGGGCTGCCTCTCTTGCAGCCGGGCCTGCCCGGTGGGGGGCATCGAGCTG
+GACCCGCCCGGGGTGCGGGTGCTCATGGCCGGCAAGCTGGGGCGGCATCCCCATCTGGCC
+CGGCCGGTGATGGAGGCCACCGGGCCAGAACCGGTGCTGGCCTACTGGACCCGGGAGCTG
+GAGGAATACCTGGCTAGCGCCCCGCCGGGGCGGCGCTTCAGCGCTTGGTGGCTGGAGCAA
+CACCCCGCGGGCTGAACCCGGAAGTCCCAGCAAGGAGGCGCGCCATGCCCATACCCGGCC
+GGCTTTTGACCACCGCCATGGCGGTGATGCCCCATACCGACGTGGACCAGGCGCTCGCCA
+GCGCGCTTAGCCTGGACATCCCCTTCTGGCCCCAACTCCCCCGGGTCAACTACTACGAGG
+ACATGTACGTCCAGGCCTCGGAGCACTTCCCGGGCATGGTGGTGGACCACAAGGAGCGCA
+CGCTCGTCTTTTCCATGGACAAGTTCATGGTCGAGCTGGAGGAGACCCTGGCTCATCTGG
+AGGAGCCGGAATACTTCGACATCTCGCCGGAGTACTCGGTGGTCTACCATCGCTTCCTGG
+AGCTGGAGCTGGCCGACCGGCCCGCCATCCGCGGCCAGTTGGAAGGGCCCATCAGCTTTG
+GGCTCAACGTCAAGGACCAAGACGACCGGCCCATCCTCTTCGACGACACGGTGCGCCCCT
+TCCTGCTGGAGGTCATGGCCCGACGGGTCAACGTGCAGCTCACCCGGCTCAAGGCCAGAA
+ACCCCAACGCCTTCATGTTCGTGGACGAGCCGGGGCTTCAGTTCATCTTCAGCGGGCTGT
+CGGGCTACAGCGACCGCAAGGCCAAGGAGGACCTGGACCAGTTTTTCGCCGCCATCGAGC
+GGCCCCGGGGCATCCACCTCTGCGGCAACCCGGACTGGGACTTTCTGCTCAACCTGGATC
+TGGACATCCTGTCGCTGGACGTCTACTCCAACGGCGAGGTCTTCTCCTCCTATGCCCGCT
+CCATCAAGCGCTTTCTGGACCGTGGCGGGGTGCTGGCCTGGGGGCTGGTGCCCACCAACT
+TCGAGCCCTTCTCGGCCGAGGACCACGTCTCGCTCAAGGCCCGGCTCAAGGAGATATGGT
+CCGCCCTGGAGTCCAAGGGGGTGGACCGGGAGCTGATGCTGGAGCGCAGCCTGCTCTCGC
+CGGCCACCTGTTGCCTGGTGAACCCCGACGGCGAGAAGACGGTGGACAAGGCCTTTGCCC
+TGGTGCGGGCGCTGTCTGCCGAGCTGCGGGACGAATACGGCCTGGACGGTTGAGGGCCAG
+CGCCCTTGACGCCTGGGTCCCGCTGTGCCATTTAGATAAGGTGAGGCCTGCCCGCAAGCG
+CCCGAAAACACGTTACTGGTAGATGGCCAGGAGGGAGCGCCGTGGAAGTGGACATCAGCC
+TGTTCTCCAACCAGAACCAGTTCGTCATCCTGCGGGTGGGCGAGCAGGCCTACGCCCTGC
+CGGCGGCCCAGGTGCGGGAGATGCAGGTGCTGCCCGAGGTCACCGAGGTGCCGCGGGCGC
+CGGCGCACCTGCGGGGCATCATCAGCCCCCGGGGCGAGGTGCTGCCGCTTTTCGACTTGC
+GGCGCCGCCTGGGGATGCGCTCCCTGGCCGAGGAGGCCGATGAACTCCTGAAGATACTGG
+AGGCCCGCGAGCAGGAGCACAAACAGTGGCTGGAGGAGCTGGAGTCCTGCATCCGCGAGG
+AACGGGAGTTCACCCTGCCCACCGATCCCGAAAAATGCGCCTTTGGCCAATGGTACCAAA
+ACTTCACCACCGAGGACCTGGCCCTGGCCTCGGTGCTGGAGCGCCTGGCCGCCCCCCACC
+GCCGGGTACACGAGGTGGCCGGCGCGGCCCTGGAGGCCCTGGAAAAAGAAGGGCAGGCCG
+CGGCCCAGGAGGTCATCGACCGGGCCCGGCGGATCATCCTGCCCAAGCTGCTGGAGCTCT
+TCGCGGAACTCAAGCGCCTGATCCGCGAAACCCACCAGGAGATCGCGGTGATCCTGGAAA
+GCGGGCGCCACACCCTGGCGCTGGCGGTGGACAACGTGGACTCGGTGGAGCTTCTACAGC
+CCAAGGACCTCCAGAACCTGGAGCGCTTCGGACCCGTCGACGGTTCGCAGGACCTCCTGG
+AGTCGGTGGGCCGCCGCGCCAACGGCGAGACGGTCTACATCCTGAAGACTGCCGAGTTCT
+TCCAGGCTGCCACCGATCTTACCTTCTAGGTGCGCCGGCGGGGCGGGACCGGCCACGGGT
+TCTCCCTGGCGGCCGGCGCGACTTTCCGGACATGACAATATATCCACACGAAGGGCGGCC
+ATGGCCCACGGGCAAGAACCAGCCTATGAGATGAAAAGCGAGCCCGCCGGTAACGGCGAG
+TTGCGGGTGGATCTCTCCGGGCGGCTGGACATGAACGCCCTGGAAGGGGCGGTGGATCAG
+TTCGGCCGTCTGCTAAAGGAGCAGCGTCCCCGCCGAGTGGAGCTGGCGGTGGGGGGGATA
+GACTACCTGGACAGCGGCGGGGCACTGGCGCTCACCCTGATGGAGGAGGCCGCCCGCAAG
+GCCGGGACCAAGTTCCAACTGGTCCAGGCCGGCCCCGAGGTGCGGGGCATGTTGGCCCTG
+GTGGACATGGACAAGATCCGCCGCAGGCCGCTTAGGCCCGCGGAACGGGGGCTGGGCTTC
+GTGGAGCAGGTGGGCCAGGCCAGCCTCGAGGTCTGGCGCGATTTCGTGGAGCTGGTCACT
+TTCCTGGGCGACTTCCTAATCGCCCTGGGGCGCTCCCTGCGCCGTCCGCGGCTGGTGCGC
+TGGCAGGAGACCTTCTTCTACATGGAGCAGGTGGGGGTCAACGGGCTGCCCATCGTGGGG
+CTGATCAGCTTCCTCTTGGGGCTCATCATCGCCTTCATGTCCTCCCTACAGCTGAAGACC
+TTCGGGGCCGACGCCTACGTGGCCGCCCTGGTCTCGGTGGCCATGGTGCGCGAGCTGGGT
+CCCATCATGACCGCCATCCTGGTGGCGGGGCGCTCGGGCTCGGCCTTTGCGGCCGAGATA
+GGCACCATGCGGGTCAACGAGGAGGTGGACGCCCTGGAGGTCATGGGCTTCGACCCCACC
+GACTTCTTGGCCATGCCCAAGGTGCTGGCCGCGCTGGCGGTGGTGCCGATGCTAACCATC
+TACTCCTGCGTGGCCGGCATCCTGGGCGGCATGGTGGTGGGCATCTGGGGCCTGGGGCTC
+ACGCCCTACACCTATCTGCACCACACCATCGACAGCCTGTCGGCCTACGGCATCGTCACA
+GCGCTCATCAAGTCGGTGGCCTTCGCGCTGATCATCGCCGGCATCGGCTGCCAGCGCGGC
+TTCATGGTGCGCGGCGGGGCCCAGGCGGTGGGCAGCGCCACCACCTCGGCGGTGGTCACC
+GCCATGTTCCTCATCATCGTGGCCGACTCGGCCTTCGCCATCCTCTTCTACTACGTGTTC
+TGATGAGCGCTGAAGATCCTATCATAGAAGTGCGGGGGCTCAAGGCCCAGTTCGGGGAGC
+AGGTTATCCTGCGTGGGGTGAGCTTTGCGGTGGCCCGGGGCGAGGTGGTGGTGGTGGCCG
+GCGGCTCGGGCTGCGGCAAGTCCACCCTGCTCAAGCACATGCTTGGCCTGTACCAGCCCG
+CGGCGGGTAGCGTACTCATCGACGGGGTGGACATCGCCCAGGCCGATGCGGCGCAACTGG
+AGTGGGTGCGGCGTCGCATCGGGGTGTTGTTCCAGTCCGGGGCGCTTCTGGGCTCGCTGA
+CCCTTCTGGAGAACGTGATGCTGCCGCTTGTGGGCTTCACCCCGCTGTCGCGCCGGGGGG
+CCGAGCTGGTGGCGCGGCTCAAGCTATCCCTGGTGGGGCTTTCGGGCTACGAGAACCACC
+TGCCCTCGGAGCTGTCGGGCGGCATGCAGAAGCGGGCCGGGCTGGCCCGGGCCATGGCCC
+TTGATCCCCAGGTGCTGTTTTTCGACGAGCCCTCGGCCGGGCTGGACCCGGTGACCTCGG
+CCGAGCTGGACCTGCTCATCAAGCGCATCAACCGCAACCTGGGCACCACCATGGTGATCG
+TTTCCCACGAGCTGGCCTCCATCTTCGAGATCGCCCACCGGGTGATCCTGCTGGACAAGC
+AGGCCAAGGGCATCATCGCCATGGGCCCGCCCCAGGAGCTGAGCGGTGTTCCTAGGCTGT
+TTCCTGGTGGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTGAGTATTCTATAGTC
+TC
+>NODE_11_length_12385_cov_59.906_ID_21
+GCCCTGGTGGCCGACCACCGCGGCGCAGGCGGCCTGGTCGCGGAAGTACTGAGCCCACAG
+CTCCAGGGTCTGGGCCAGCCCCTGGCGGTCGATGACCGCGCCGCGGTGGTCGGCCACCAG
+GGCCTCGGCCAGTTCCCAGTCCTCCAGGGCGCCGCCGGGGCGGGAGAGGTGCTCTTGCAG
+ACGCCCCAGCTCCCGGCGCAGGCGCGCCGGGTCCAGCTCCAGGGCGCGGCCCAGGGAGCC
+GCCGCTCATGGCGGCCTTGAGGCGGGCGTCTTGGGGGTCCAGCCCTCGGCGGGTGAGCTC
+GTCGACCACCAGCTCGGGGTCCAGGGGGGAGAAGTTCACCCGGCGGCAGCGACTCACCAG
+GGTGGGCAGCACCTCCCGGGGGTCCTGCACCGTGAGCACCAGGATGTTGTTGGGCGGGGG
+CTCCTCCAGGGTTTTGAGCAGGGCCCCGGAGCTGGCCAGGTTGAGCCGGCCCGCCTCGCG
+GATCACCACCATGCGCCAGCCGCCGCCAAAGGGAGCGAAACTGAGCGTGCGGATCACCTC
+ACGCACCTGCTCCACCTTGATCTGGGCCGAGGGCGAGTCCGAAGGCGGCTCCACCACCAA
+GAAGTCCTCGTGGTTGCCCGCGGCCAGGCGGCGGCAGGGGCCGCAGGCGCCGCAGGGGGT
+TTCGCCGGGGTCCTGGCAGTTGGCCGCGGCGAACAGGGCGCGGGCGGTGGTGGTGCGGCC
+CACCCCCCGGGGGCCCACGAAGAGGTAGGCGTGAGCCAGGCGGCCGGCGGCCAGCTCGGC
+CTCCAACTGGGCCCGGGCGCGGGCCTGTCCCAGTACGCCGTCAAGCCTCACGGGTCTTCC
+TCCATGACTCCAGCAGGGGCCGGGCCACCTCCCAGATGCGCCGGGCCACCTCCGGCCGGG
+AGCCGGCGGCCTCGATCAGCCGCACCCGCTCGGGTTCCTGCCGGGCCAGTTCCAAAAAGC
+CCTCCCGCACCAGGCGATGGAACTCGCCGCCGGCCTGCTCCAGGCGGTCCAGTCCCTGTT
+TGCCTTGGCGATGGCGGGCGCGGGCCAGGCCCAGGGCGGGGTCCAGGTCCAGCACGATGG
+TGAGATCGGGCCAGGTATCCCCGCAGAGCCAGCGGTTCAGCTCCCGCACCCTGTCGGCGC
+CCAGCCCTCGGGCCAGCCCCTGGTAGACCTGGGTGGAGTCGGCGAAGCGGTCGCAGACCA
+CTGCCTCTCCCGCGGCCAGGGCGGGCCGGATCACCTGCTCCAGGTGCTGGGCCCGGTCGG
+CCAGATACAGCAGCAGCTCGGCCTGGGGACAGGGGTCGGGTCCGGCGGGATCGGCCAGCA
+GACGGCGCAGGGCCCCCCCCAGCTCGGTGGCCCCCGGCTCGTGGGTGAGCAGCGCCGGCA
+GGCCCAGTTCCCGGATGCGCTGGGCCAGCAGGCTGGCGTGGGTGCTCTTGCCGCAGCCCT
+CGCCTCCTTCCAGGGTTATGAAGGGCGCACGTTTCATGACGACTCCGGCTCTGGGGCGGC
+TTCCGGCCGACGGCCGGCGGGACAACCCAAAAATGCCAGAAGCGGAGCCGGGAGTCGACC
+TCTAACTTGAAGCGGGTGGTTGGCGGATCGCAGGGGGTTTGTGTCGGGGGTCTTCACCAG
+GTCAGGGATGAAGCTCTCGCGTGTCGACGGCATCGCCCGACACGTTTTGCGAGCCGGAGT
+TTACGGCGGCTCAGACCGGTACGCCAGGGGAGGACTGGTGGGCCAAGTACATCTTCGAGG
+AGTCGCCCAGGCCGCTCAGCTCCACCCGGGCGGTGGCGTTGGCCCCGTGGCGGTAGTAGA
+GGTAGAGCTTGCCGTCCTGGAGGGAGAGCTCGGGGCCGTCCATGCCCATGCCGGGACGGT
+CGTTGACCAGAAGCGGCCTGCCGGACATCTTGACCCAGGGGCCACCGGGGCTGCTGGCCC
+GGGCCAGGTTGGTGCCCCATTGGGAGCGATGGAAGTCGGTGTTCGGCGAGCAGACCTCGT
+AGGCCATGTAGTAGAAGTCTCCCACCTTGACCACATTGCTGCGCGCCCCCACGGTACCGC
+CCTCGATGCCCTGTGGGTCCACGTCCAGCAAAGGCCCTTGGTTCACGGTAAGGTCTTGCA
+GGTTCTCGCCGTGGGCGTAGCCGATGCGAACCCTGCCGTCCTTGGCCAGGGTGTGGAAGT
+AGACGTGCCACTGGCCGCCTTCCTTGAACATGGTGGGGGTGCCCACGTCCACGGCGCTGA
+TCTCGCCGGCGTCGCCGGGCTCGATCACCGGGCCGTGCTTGGTCCAGTTGCGGCCGTCGG
+GGCTGGTGGCCAGGCAGACCGTGTTCAGGTCGTCGTGATCGGCCTTGGCCTCGTAGAGCA
+TGTACCAGGTATTGGTCTCGCCGTCGTACTGCACGGCGGGGAAGCTGGCCATCTGGGCGT
+CGAAGCCCTCGGGTCCCTTGGTGAGCACCTTGCCCTGGTACTGGAAGTTCACCCCGTCTT
+TGCTCACCGCCAGGCCCACGTCGTTCTCCGAGCCGTGGCTGTGGTCGATGAAGTAAGCGT
+AGGTGAGTCCGTTTTTTTGCACCAGGTGGGGGAAGTGGAATTGCTCCACGTCGGCGTTCA
+CCTCCTGGCGTTCACCCACCTGCACCTCGGCCCGGAAGCGGCTGCCGTGGTAGGTGCTGA
+TGGCCGACGGCAGGCCGACGTCCTCGTTTTCGTGCTCGCTGGAGGGCGGGGGCGCGGGCG
+GCGGCGGCACCGTCCGCAGGGGGAAGGTGGAGCGCGGGTTGGCGGAGTGCATGCGGTAGG
+CGCCCTTGGGCGCGGCCGGGGTGGGATCGCTCCACACCACCGGGGCGGTGAACAGCCCTG
+GCGCAGCGCCGATGCTGGCCCCCACCAGCAGCGGGGAGTGGGGGCTATAGCGCACCGGCC
+CGCCGGTTTGGCGCGTAGCGCCGGTGGAGAGATCTGCGGGCTCCCCCTGGCGCAGCTTGC
+CGTCCAGCATCCGGGCAAAGCCGGCGCCGCCGGAGACGCCGCCACTGCCGGATGTGTCGC
+CGGAGGCGGGGGGCGTCTCCTGTCCCGGACGCCACAGGCCCGCCAACGGGTAGCTGCTTT
+GTACGAACTGCACCGTCCAACCGCTCCTTGGGCTTTGGTTCCACTGCGCTAACATGCAAA
+TCACCTGCCAAGCGCCCCCAGCCCCCCTTGCGGTCAGCGGCTATTGCCATTATTATAGGA
+CGGCACAAAGCATTATGCCTTTGACCTGCCCTGCCTGCTCTTGCCTGCTCCTGCCTGCTC
+CTCTGCCTGCTCTTGCCTGTTTAAGTCTGCACAAGTGAAAAAGAGGAAGTTTTTTCCTGC
+TCACTGGGTGAGAATGGAGGTAGAGGTAACGGGGAAGTATGAGCAAGCTTTTCGGCATAC
+TGGCGGGTCTGATCGGCATCTTTCTTCTGGTAGCCAGCGTAATTTCTTTTGGCCATTTGG
+TGGAGGACGCATGGGTCAGAGGTGGGATGTTGGCCTCACTTTTGTTTGCTCTGCTGCTCC
+TGCTGGGCAGTGCGGCCTTCCTCCTCACGGCGGTGCTCCTTTTCCGTATGCGTTCCCACT
+ACTTGCCCAGACTCTACGAGTTGGAGGAGCTGGAAGGGCTGGAGGAGCCCCCACCAAAGA
+CGAAAGATTCAGGGGAATCGAACGGCCCCCGCCTGGCCTGATCCCGCGGCAAGGGAAAAA
+AATGCCCCATCCCCAAGTCCCGCTTTCCTGAAACCTCGTCCTGAATAAAGCCCTTTAATC
+CCCACGGTTAGCCCATAAGGCCCGCCGTTGGCATCCGCTTTGCTTGAGTTGAGGCCGAAG
+TGGTATCCCCGCTTGGCGGGGGCAACTGGATGAGTGCCCCGGGTTCCTCGTGGGACCCGG
+CGGGAAGGGATGTCTCGGCATGGAAGCCAGAACCTTGTTCAACGGCGCCCTGGGGGTCAA
+GGCCCACGTCCGGGGCCTGGAGAGCGTTTCGGACAACATCGCCAACGTCAACACCTACGG
+CTACAAGGCCACCCGCGCCCAGTTCAGCGACCTGCTCTATCAGGAGATGGCGGGGGGCGC
+CGGCTTTCCCCAGCAGGTGGGCAACGGCGCCTTGACCGCGGTGGAGAACATGATGATGCA
+GGCTCCCCTGGAGCCCACCGAGAACGTGCTGGACATGGCCATCAACGGCAGGGGGTTCTT
+CACGGTCAAGCATCCCGACCGCAACGAGGGCAACCGCTACACCCGCGCCGGCCAGTTCTA
+CCTGGACAAGGACTATTTCCTGGTCAATTCCGAGGGCTACCGGGTGCAGGGCTTTGCCGT
+GGACGCCGACGGCAACGTGAACGTGAACCAGGTCCAGGACATCCAGATCGACAACCAGAT
+CCAGGATGCCACCGCCACCACCAGCGTGGACCTGGCCGTGAACCTGGACGCCTCGGATAC
+CACCGAGTTCCGCCAGGCGGTGGCCATCGATCCCACCGACAGCGGCACCTACAATTTCCG
+CATGGGGTTCCAGGTGGTGGACGAGGACGGCGACACCCAGGACATCGCGGTGTTCTACCA
+GAAGCTGGAGAGCTATACCGGCGACGCCCCTGCCGGCAGCCAGAGCGTCTGGAAGGCGGC
+CACCTTCCACAACGACAGCGGCACCCTGACCGCCGACCCCAGCTACCCGGACAACACCTT
+CTTCCTGCACTTCGACACCAACGGCCAGCTGGTGGGGGTGACCACCGGCACCCCGGCCAC
+CGGCGACTCCTACACCTCCAACGCCGAGGTGTCCAGCACCAGCGCCTCGGTGAGCGACCG
+CCTGGGCGAAACCTTCGCCTACACCGGCGCCGGCAACACCCAGACCCTGCGCTCCACCGC
+CACCATCACCTTCTCCGGCACCACCACCGCCGGCGACACCGTGACCATCGGCGGCACCAA
+CTATACCTTCGCCGCGCTCTCGCCCAGCGACGCCGCCGCTTGGCTGGCCGACCAGATAAA
+CGCCAACTCGGCAGGCAGCTACTACGCCCAGGACGACGCCTCCGGCACCGTGACTCTCTA
+CGCCAAGGACGGCACCGCCGCCGCGGAGGTGAGCGCCTCCTCGGTGGTGATCTCCACCGA
+CGACACCATGAGCCTCACCGAGCTGGTGAACACCGTGGACAGCGGCCGCAAGGCCACCGG
+CTCGCTTTTCGTCAACATCGCCGGGCTCACCGCCGGCAGCTCCACGGTCACCGTGGCGGG
+CCACACCTTCACCTACGGCCCGGCCCAGGACTTCACCACCCTGAGCGAGCTTACCACGCT
+CATAAACGATCTCTCCGAGGTGGACGCCACCAGCAGCGGCCATAATATCTACATCACCGC
+CGCCAGCGTCGGCACCAGCGGCAACTCCCTGGGGCTTGCCACCAACGATGCCGCCAACGT
+GGCGGTCAGCGCCAGCACCCTGCTGAACGGCCTGGACGACAGCGACGCCACCAACATCGA
+CGCCTCGGCCACCACCGGCTCCGGCGGCGGGCAGGCGCTGAAGCTGGACCGCACCGACGT
+GGGCGCCTCGGCCACCATCGACGTGGCCACCACCAACACCCTGGGCAGCAACCTGGGGCT
+GGACTTCACCGGCGGCAACTTCACCCAGAACTCCACCGCCTCCGACGGCAACGGCACCAG
+CAACACCACCGGCGAGGTGCCGCTGACCTTCACCTTCACCAAGAGCGGCTCCACCCTCAC
+CCAGCAGGTGACCCTGGACTACTCCCCCACCGACGGCGACGATTCCACCATGCTGGCCGG
+CGACTACGAGACCTTCTATCTCAAGACCGACGGCAGGGGCACCGGATACTTGAAGTACCT
+GGAGATAGACGACCAGGGCCTCATCACCGCCCACTACACCAACGGCCAAGGCGTGCCCCA
+GGCCGCCCTGGCGCTCACCACCTTCATCGCCCCCCAGGAGCTCTTGCGCGAGGGCGACAA
+CCTCTGGCGGGCCACCGCCGCGGCCGGGGTTCCCACCGTGGCCCAGGCCGGCGACGCCCA
+GACCGCCATGGGCGAGGTCAAGTCCTACGCCCTGGAGCTCTCCACCGTGGACCTGGCCCA
+GGAATTCGTGAACCTCATCAACTACCAGCGCTCCTTCCAGGCCAACAGCAAGTCCATCAT
+CACCGGCGACGAGATGCTCAAGACCGCCATCAACCTCAAGGGCTAGCCCGCGGCACTTGC
+CAAGCCCACCCTCCGCACGGTAAAGGGGCGGTATGGCCCCTGGGCCGCCGGCCCCGCCGG
+GCGGCGCGTTTCACCCGCGCGGAGGAGTAGAGATGGACCACGCAGCCTTGCCGCAAACCC
+TGGCCCCCGGGCTGTACCGCCTGGGCAGCTATCACCTGGCCTGCTTTTTGGTCGAAACCC
+CTGATGCCGCCCTTTTGTTCGAGACCGGCATGTCGCTGGTGGCGCCGCTGATCCTGGCGC
+AACTGGACGAACTGGGAGTGCCGCGGGAGAAGATCCGCTGGATCGTGCACAGCCACGCCC
+ACTCGGACCACTCCACCGGCCAGGCCGCCCTGCTCGAGGCCCTGCCCCGGGCCGAGCTCC
+TGCTCAGCCCCACCAGCCGCAGGCACCTGGCCAAGCCCTCCACCGCCGAGCAGTTCGCCA
+AGGAAGACGACTCGACCCGCCGCGCCCTGGAGAGGATCGGCGCCCTGCCCCCCGGTTCCT
+TGCCCGATCCCCTGCCTTTGTTGCCCGCGCGCCACCGCACGGTGGAGCCGGGGGACACCC
+TGGACCTGGGCGGGCTCACCGTGGAGCTGCGCTCCGCTGCGGGGCACGTGCCCGGCGGGC
+TCTTGGCCTGGCTGCCGGAGCTGGGGGCCTTTCTGGCCTCGGACTCGGCCGGCTTCCACA
+TGGCCGCCCGGCCCAACTACCCGCTGTACTTCACGGGCTACCGCGAGTACCTGCGCACCC
+TGGAGGAGATCCGCCGCACCAACCCCGAGCTGCTCTGCCTGGGGCACCAGGGTTGGTTCC
+GGGGCGGGGAGGCCCGGCGCTATCTGGAGGCGCTCAAGGCGCACCTGGCCTTCGAGCATG
+CCACCATCTGGGAGGCCCACCGCCGCGGCGAGGACGAAGAGAGCCAGGCGCGGCGGCTGG
+TGGAGCGCTACTACCACGACGAGCTGGCCATTTATCCCCGGGACATCCTGTGGTACTGTT
+GCCGCCTGTTGGTGCGGCGCAGCCTGGAGGCGGGCGCCTGAATCGTCCCGCCGGGGTTGC
+CCTGGTGCGCTCTGGAAGGTAAAAAGGGCGATAACCCCGGGGGGAGAGGACCGCTGGTGA
+ACTACGAGCCCTGCGTGAAACACAAGGTGGTGCGCAACACGGTGCGCGACTTCGCCGAGG
+CCGAGTTGCGCCCCATCGCCCACGAGGTGGACCAGAACTCCCGCTTCCCCTGGGAGGTGG
+TGGAGAAGATGCGGGGCTTGCAGTATTTCGGCCTCCAGGCCCCCCGCGAGCTGGGCGGCG
+CCGGCCTGGACAGCATCAGCTACGCCATCGCCATCGAGGAGCTGTCCCGGGTCTGCGCCG
+GCATTGGGCTGTGCGTCACGGTGCACAACTCGGTGGCGCTGTACCCTCTGCTCAAGTTCG
+GCAGCCCCGAGCAGATCGAGCGCCTGGCTCTGGATTTGATCAGCGGCAGGCGCATCGGTG
+CCTTTTGCCTCACCGAGGCCGGGGCCGGCTCAGACGCCGGGGCGGTGGAGACCCTGGCCC
+TGCCCTGTGATGAGGGCTACCTCATCAACGGCACCAAGATATTCGTCACCAATGGCGGCG
+TCTGCGGCCTGGCGCTCATCTTCGCCAAGACCGATCTCGACCATCCCCGTGGCGCGCCCT
+CGGTGCTCATGGTGGAGAAGGAGCGCTCCGGCTTTGCGGTGGGCGAGATCGAGGACTTGT
+CGGGCATGCGCTGCAACCCGGTCTCCTCGCTTTTCCTGGAGGACTGCCTGGTGCCGCCCG
+AGAACCTGTTGGGCCGCCGGGGCGACGGGTTGCGCATCGGGCTCAGCGCCCTGGACACCG
+GTCGGCTGGGTATCGCCGCCCAGGCCCTGGGCATCGCCCAGGGCGCCTTCGAGGCCGCGG
+TGCGCTACGCCAAGGAGCGCCAGCAGTTCGGTAAACCCATCGCCCGCTTCCAGACCATCC
+AGAACTACCTGGCCGACATGGCCACCAAGATAGACGCCGCCCGCATGTTGCTCTACCGGG
+CCTGCGCGGCCAAGGACCAGGGCCAGCCCTTCTCGGCCGAGGCGGCCAAGGCCAAGCTGT
+TCTGCTCGGCCACCGCCCGGGAGGTCTGCAACCTGGCGGTCCAGATCCACGGTGGCTATG
+GCTACAGCAAGGAATACGAGGTGGAGCGCTACTACCGCGACGCCAAGGTGACCGAGCTCT
+ACGAGGGCACCAGCGAGGTGCAGCGCATGGTCATCGCCCGGGCCATCCTCTCGGCCCCGG
+CCTGAGCGCCGGCGCCGGCTGCGTGAGGGAAACATGAAACTGGTCGTCTTCCTCAAACAG
+GTTCCGGGCGTCACCGAGATCCCCTGGGATCCGGCCAGCGGTCACCTGCGCCGTGAAAAG
+GCCCCGGGCATGATGAACCCCGCCTGCCGCCACGCCCTGGAGGCGGCGCTCATCCTCAAG
+GAGCAGCACGGCGGCGAGCTCACCGCCATCAGCATGGGCCCGCCGGCGGCCGAGGAGATA
+CTGCGCGAGGCCCTGGCCCTGGGGGCCGACCGCGCGGTGCTTTTGAGCGATCCTCGTCTG
+GCCGGGGCCGACACCCCTGCCACCTCCTACACCCTCTCCCTGGCGGTGCGGGCGGTCTGC
+CCCGACTGCGACCTCCTGCTTCTGGGCAACCAGACCAGCGACTCCGAGACTGGCCAGGTG
+GGGCCGCACCTGGCCGAGGAGCTGGATTTGCCTTCCGCCATCAATGTGGAGGAGCTGGAA
+CTGGATGGCGAGGTGCTCAGGGTGAAGCGGCTGTGCGACAATTTCCTGGAAACCCTGGAG
+ATGGACCTGCCCGCCCTGGTGACCATCAACACCCAGGGCCACCCCCCGCGCCAGGTGCCC
+CTGGGCGGGGTGGAGGACGCCTTCTCCCGGGGAGAGTTCCTGGTGCTTAACGCCGAGGAC
+TTGAAGGCCGACCTGGCCCGGGTGGGGATGACCGGCTCGGCCGGGCGCATCGTGAAAGTT
+TACCCCGCCGGCGGCGAGCGCAAGGGCGAGCTGATCAAGGGAGCGCCCAAGCGCTGCGTG
+CTGGAGCTCCTGGAGCGCCACGGCGACCTGTTGGGCGGCTATTTGCGCAAGGACCTGGGG
+GGTGGGCGATGAGCCGCCGGCAGCAGGAAAACGGCGCGGTGTGGGTCTTCGGCGACTACC
+GCAACTACTTCCAGAACCGGGTCACCCTCCAACTCCTGGCCCGGGCCCGGGACCTGGCCT
+CCCATCTGGACACCAAGGTGGCGGTGGTGGTGATGGGATATCGGGTGGGGCGCTGGGTGC
+GCGAGTACGTGGCCCACGGCGCCGACGTGGTCTACGTATTGGACCATCCCTCGCTCAAGT
+ACTACCTGGTGCAGACCTACACCCGGCTTATGGAGCGCCTGGCCGGCGAGCACCAGCCCC
+AGATCATCCTGGTGGGCGCCACCGGCTTCGGCAAGGAGCTGGCCGCCCGCCTGGCCAGCC
+GCCTGGGCACCGGGCTCACCGCCGACTGCGTGGATCTCACCGTCGACGATCAGGGCCGCT
+TCATCCAGACCGCCCCCTCCTTCGGCGGCAACCTCCTGGCCCAGATCATGATCCCCCAGG
+CTCGCCCCCAGATGGCCACCGTGCGCCCGGGCACCTTCCAGGAGCTGCCCCACGACGCCG
+ACCGCCGCGGCGAGATCATCAAGCTGCCCCTGCCCGACGATCTGCCCCCCGAGAAGGCCC
+GGCTCATCCACAGCCGGCGCATCAAGCCCCGGCGGCGCAAGCTGGAGAAGGCCCGGGTGG
+TCATCTGCGGCGGGCGCGGCATGGGCAGCAAGAAGAAGTTCAAGAACCTGTACGCGCTGG
+CGCGGCTGCTGGGCGCCCAGGTGGGGGCCACCCGCCCGGTGGTCTACCAGGGCTGGGCCC
+CGGAGGATGCCCTGGTGGGCCAGGCCGGGCGCGACGTGCATCCCGAGGTGCTGTTCTCCT
+TCGGCGTCTCCGGCGCCATCCAGCACACCGCCGGTATCCACGACGCCCAGTTCATCGTGG
+CGGTGAACAAGAACCCCGCCGCCCAGATGATGAAGATGGCCGACGTGGCCATCGCCGCCG
+ACGCCAACCAGGTCTGCCTGGCGCTGATCCGGGAGCTCAAGGCCCGCCTGGAGAAGAAGA
+AGTAAGGCTCGGCGTGGGGTGACGGCGTAATCGGGGGGTTGGGGATTGGGAGCCGGCCGG
+GGTCCGCGCGGCGGAGCTCAGTCGCCCTCCAGCTCCTGCCACAGCTCCAGCACCGCCCCC
+AGGCTGGGGCAGGCGCGGGTCGGGTCGGCGGCCAGCTTCAGGGCCTGGGCCGGGGTGAAG
+AAGCGTCCGGTTTCTATCTCCTGGGGATTGGGACGGGGCGGTTCGGCGCTCACCCCGGTG
+AATATCTCCACGAACTCGTTCTCGGTGCGGGGGCCGGCCGGCAGCCGGCCCAGGGGCCGC
+AGCTCGGCCTCTAGCCCCAGTTCCTCGGCCAGCTCGCGGGCGGCGCATTGGGCGTAGCTC
+TCGGCGGGGTCCACGTGCCCCGAGGCCGAGGAGGTCCACTTGCCGGGGTAGGTGTCCTTG
+GCCGCGGAGCGCTTTTGCAGGTAGAGCCTTCCGGCGGGGTCGAAGAGCAGCACGTGCGCC
+GCCCGGTGCAGCAGGCCCTTTGCGTGTATCTCCTGGCGGGTCATGGTGCCGATCACCCGG
+TCCTGGGCGTCCACCACCGGCAAGAGCTCCTGGGGATCGGTGTAGTTCACGTCTTCTCCC
+CTCCCAGCAGGCCCAGCGCCGTCAGTTTGTCCAAAAACAGCTCCACCAGCTCCGGCGGCA
+CCAGGCAACTGCGCCGGTAGCTCACCCGGGGGTCCACCAGCACCAGTTGCAGCCCCCCTT
+CGGTTTCCTGGGCGCTCACCCGCACCTCGGGACTCTGGGCGGCCCGCTCCAGCTCGGCCA
+GAAGCGACAGAAACAGGCGATAGCAACGCCAGGCGCGTTGGCCCGCCTCGCTCTCGAACT
+CCAGCAGGTTGCGGTTGCGGGCCACCGCCCCCGGTGAGCGCAGCATCTCGGCCACGCGTT
+GCAGAACCTCCGATTCCATCTTCGGACCTCCTGCCCGGTCACCATATCTCCCTCTCTCTA
+GCTTGCCCCAAGCGGCCCCTTGTGGCAACCTGGGCCGGCAGAGTTTTACCCGTAAGCCCG
+GAGGTCCGCCCCGTGTCCCGGCCCCGCTACGTACGCACCCAGCGCCATGGCCCTGTGACG
+GTGGTGGTGATGGACAACCCCGCCACCATGAACGCCATGGACCAGGACATGGGTCCCCGC
+CTGGTGGGCGCCCTGGAGTCCCTGGCCGCCGACCGCAGCGTGCGCGCCGTGGTGCTCACC
+GGCGCCGGGGGGAGGTTCTCGGCCGGGGGCAACCTGACCCGGGCCGAGGAGTTTTTGGAG
+GAGAACCCCGGCCGGGGCGCGGCGCCGGTCTTCGCCCAGTACACCATCTGGGTGCACCGC
+CTGCTGGCGGTGCTCACCCGCCTGCCCCAGCCGGTGGTGGCGGCGGTGGAACGCGCCGCC
+TCGGGCGGCGGTCTGGGCTGGCTTCTGGCCTGCGACCTGGTGGTGCTGGCCGAGGACGCC
+CGGCTCAGTACCGGCTTTCTGGCCATCGGCCTGGCCCCGGCCGCCGGGGTGAGCTGGCAC
+CTGCCGCGGCTGGTGGGCCTGCCCCGGGCGGCGGAGCTTCTGATGCTGGGCCGCACCCTG
+GGGGCGGACCGCGCCTTGGAGCTGGGACTGGCCGACCAGCTGACCCCGCCGGGAGGGACC
+CTGGAGGCGGCGTTGGAGCTGGCTGGCGAGCTGGCCCGGGGGCCGGCCCAGGCGCTCGCC
+GCCACCAAGCAGCTTCTGGGCGGGGCCGCCCGCCGGGGACTCTTTCCCCAGGCCGAGGCC
+GAGCGCCGAGCGGTCTTGCACACCGCCGACCAGGAGGAGTTCGCCCGCAGGCTGGAGCGC
+TTCAGGCAGCGGCGGCGGCGGAGTTAGGCTCCCGCCGGCCAGGGACTTATATACGGGCGC
+CGGTTGCCCCCCGGCCCGTCAATTGGTATTATTCCTACGAGTCTTCAAACATTACCCGCC
+AAAGCTTGAAGGAGCAGCCATGCCCATGGACTGGACGCCGCCCCCGCGCGGCGGTGGGCG
+AGAGCCCGATATAAACCAGGTGGTGCAGAACCTGAAGAACCGCCTGCCCGTATTCAAGAA
+GGCCCGGGGGCTTTGGCTGGCGGTGGCCGTGGTACTGGCCATCATCCTGGGGGCCTCCTC
+CTACTACACGTGTTCCTAGGCTGTTTCCTGGTGGGATCCTCTAGAGTCGACCTGCAGGCA
+TGCAAGCTTGAGTATTCTATAGTCT
+>NODE_12_length_10380_cov_58.6117_ID_23
+CCTTGAGCAGCCAGATGAACTCGTCCCACCATCCTATGAGTCCGATGATTCCCAGAATCA
+GCGCGGCCAGTCCTCCAACCAGCGCGACCATATCATGTACCTCCCGTGGGATATAAGGTT
+TGTCGGCCGCGGGCCAGGGAGCCGGAAGGCGTCTTCATGCGCCCCGGCAAGGCGCCTTTC
+TTTGCGCCCCTACCCCTTCCGCGGGTCCCTTTCCGTAAATCCTTAATGTTTTATGCCTTG
+TTTACCACCTCTAGCACGGGGGGGACGGCGATGTCAATGCAACTCGCGGCAGAACCAGCC
+TTCTTGGCGCTGCCGCAGCTCCCAGCGCCGGCCGCGGCGATCCTCCAGGCGGTAGCGCCG
+GACATAGGCCAAGCCGCTTTCCGGGGCCACCAGCTCCTCGCCCAGCAGCCGCACCTCAAG
+CCACCTCCCCTCAACTCGTATGGCCAGCGGGGTCTGCTGGGCGCGGCCGCCGCTCATGAA
+GCGCACTTTGGCTGGGAACCAGTCGCGGCTCACTTGCGCCAGGCCCCGGTGACCCGCTGG
+TCGCTGGCCCCCAGGTCCAGGAGCAGGCGGCGCAGCTCCTCCGGCTCGGACACCCCGAAT
+AGCTTGAGATAGGGCTCTTGTTGATTCTCCAGGTAGACGTGCACGTGGGCCACGCCGGCC
+AGGCGGTGGAAGATGCCGCGTCTCAGGTCGATGCGGGTGATCTGCTCCACCGGGGCCTGG
+CGCTCCAGGGCGCGGGGGAAGGAGCGGCGCCAGCCCAGCCGGCCGTCTGCCAGCTCATAT
+AGGTTGCTGAAGCGGGTGATGAGAATAAAGGCAAGAAAGCAGGTGGCGATGAGGTGGCTT
+AGGTCGGGGCTGATGGGGGCCTGGGGGTTGACCCGGGGCCCCACGGTGAAGATCACCACC
+CCCAGGAAGTAGGGCAAAAAGGACTTCCAGGCCGGGCGGAACTCACGGTATTTGGCGAGG
+GCCTTACTTTGGTCCATACTGGTTCCTCACTTCCCCGACCGGCCGCCCTGCCCGCCGGGA
+CGGGCAGGGCCCTTCACCGCCGGGGCGTCCTTGCCGGCCGGGGCCAGCAGCCTGAAGAGC
+ACCACCGCCGGCGGCAGGTCGCGGCGTCTGGGGTCGGTCAGGTAGAAGGCGTCGATGCGG
+GCGGCCAGGTCCTGGAGGCTGAGCCCCTGATAGGCATTGAGTACCCGCTCGGCGCTGCGC
+GGGGCCAACTCCAGGTACTGCAATGCATCCATTATGCCACGCAAGTAGGCCAATTTTATC
+AAAATATCTGCCCTGCTCCCCTCGGGGGGCGGCCAGGCCTCGCTGGGCAGCAGACGCAGG
+TCGGCGCCCTTGTTCACCGGGGCCACCACGTACCCCGCCCCGGCCGCCACCGCCGGAGGG
+GCCAAAAGCAACAGCCCCAGCAGGCCCAGCAGGCAAGCCCCGCGGCGGCCCTTACCAAAA
+AAGCTGACCAAAAGCGCCATGTTATGCTATCCTTGCTGGAGTAAGCACCAGGGAAAGGCC
+CAAAAACAGGCCCATGCAGCGCTCAAGTGGCAGCATAACCCAACTGGCCCGATTGGTCGA
+GAGCCTGGCAGAGTTGCTAAGGCTTCACTACGGCCCGGACGGCCTGCCCGCCGCCCAGGA
+GGAGGACTTGTGCTCCCAGGAGGTGGAGGGCAGGCGTTTGGGTGAGCTGCTGGCCGAGTT
+GTGGCCCGATTCCGGACCCTGGCGGGGTCCCTGTCTGGGTCAGGGGGCCATCCGAGAGAC
+CGAGCGGCTGTTGCGTTATCGCCTGCAACAGGCGGAGGCGCAGAACCGGGCCCTGGCCAC
+CCGCCTGGAGCGGGTACGACGCCAGGTGGCGGCCCAACGGCGGACCCTCCTGGAGCAGTT
+GCGGGCGGCCAGGCTACAGGTGGAGCAGGGTCAAGCCCGGCTGGAGGCGCTGAGCGCGGA
+GCTTGGCGGCCTGCGGGCGGAGCTCGAGCGGCGGCGGGAGCGGGCCCGGCGGCGGCGGCG
+CTACCTGGAGGGGGTGGTCCCCCGGGGGATGAACCGCTTTGCCGACGCCGGGGGCCGGAT
+ACTGGACCAGGCCACCCTGCGGCGGGCCACCCGGGAGCTGCGGGAGTTGCAGGCCCTGGT
+GGTGCGAACCAAGGACGCCTGCGCCCGCCTGGAGCACCGCTGGGCCCGGGCACGTCTGGA
+GCTGGCCCGGGCGCGCTCCCATGAGGCCGGTCTGCGGGCCGAGCTGGCCCGCCTGGAGCC
+CTACTGGCAGGCCAAGACCCACCGCCTGGCGCGCGCCAAGGTGGTACTGGCCGCGCGGCA
+GGAGGAGCTGGGTCCCCTGGAGCGCAACCTCCACCGACTGCGGGTCATGGGTCTGGCCCA
+CGCCGAGGTGGTGTCCCGGGGGCGGGCGGCCCTGGAGCCGCTGCTGGCCCCGCTGGCCAG
+CGGGGAGTCTCCAGACCCGGTGGAGAGCCTGGAGGAGTCCCTGACCCAAGCCGGGGAGCA
+GGCCCGGCGCGGCCGGCGGCTGACCGCCCTCATGGAGCGCCTGGGCCGCCGCCTGGAGCG
+CCGCCTGGAGGCCATCGGCCCGGTCCTCAAGGAACAACGCCGTCTCAACAAGGAGATCAC
+CCGCCTGGAGAACGAGCTGCCCGGGCTGTTGGAACCCCTGCTGGCCGGCGACGGGGCCGA
+CCCCAGGAACCGCCAGGAGGCCGGGGCCCGCTTCTCCCTGCTCATCGCCCGCCTGGAGGA
+CCTGATCCCCCAGGCCCGGGCGACTCAGGAACAACTGGACGAGCTGCGGCAGGCGCTTAC
+CATCGGCCTGTCGCGGGGCAAGGCCTGGCAGGCCGCCTGGCGCCGAGCCGGCAAGGCCGA
+GCGGGCCGCCCTGCACCAGGCCCAGGCCCTGGTGGAGGAGGTGCGCCTGGCCGCCCGCCA
+GGCCGCCCGCCAGGCCGAGCACCTGCGCCGCCGGGCGGAGCCGGCGGTGAAGGCGCTCTC
+CCCCCTGCGTAGCCAGGACCTGCTGCCCTCCCTGGCCGCCCTGGCCCAGGGAGTGAGCCG
+AGGTCAGCTCAAGGCCCGGCAACTGGAGGCCCGGGCCGCCGAGCTGGAAGGGCGCATCCC
+CCGCCCCTACTTCGGCAACCTCTCCAAGCCGCCGGTGGCCCTCAAGCCGGTCTCGGCCGG
+CCTGCGGCGGCTCAGCGGCAAGCAGGTGGAGCTGGAGCGGCTGGCCGCCCTGGAGCGCGC
+CGCCCGCCGCTGGCAGGGACTGTTGGACGGGCCCTTGGTGGAGGAGATCCGCCGTCCGGT
+GGAGCAGGTGGCCCTGCGCCTGGCCCGCAGCCTCACCCTGCTGGAACGCCAGAAGAACCT
+GCTGGCCAGCCGCCATCAAAAGCAGGGCCGGGAGCTATCCACCCTCAAGGCCGAGTTGGA
+TCAGCGCCGCCGGCGCGAGGAGCTGGCCCGCCGGCGCCTGGAGCAGGTGCGGGACCGCAA
+CCGCCGGCAGCAACGCACCATCCGGAATTACGAGACGGAGCTGAAACAGGCCCAGACCCG
+GGCGGCCCTGGCCCAGCGCCTGGAGGACGAGCTGGCCCGGCTGGGCGAGCACGCCCAGAC
+CCTGGCCCGGCGCCTGGAGCGGAGCGACAAGCTGGCCGCGGCGCTCAAGCGCAAGTCCCT
+GGAGCGCCACCGCCTCTACCGCCGCTCCCAGTACGCGGTGGAGTGGCTGGACTACTGGCG
+CGAGCGGGCCCTGGAGCAGGAGAAGCTGCTCAGCAGCGCCCGGGCCGAGCTGGAGCTGGC
+CCGCCGCGAGTACCAGCAGGCCCGCAGCCTGCTGGCCAGCGCGGTGAGCGAGCGCGACCA
+GGCCCTCAAGGAGCTGGCCACCGAGCGCGCCGCCCGTGCCCGCCAAGCCCTGGACCTGTT
+GGGCGGCAAAGCGCTTTCGGTGGAGCTGGCCGCCAGCCGCAGCGAGGCCGGGCGCTGGGC
+CAAGCTGGCCCAGGACATGGCCCTGGCTCTCGCCGCCAGCGGAGAGCATCACCGCCAGGA
+AACCGCCGATCTCAGGGCCCAAGTGGACCAGCTCTCTGCCGAGGCGGCCATGCTGAAGCG
+CCAACTGGAGCGCATCGCCGCCATGGTGGAGGTACAGGTCCCGGGGCTGGAGGAGCTGGC
+CGATCTGCCGCCCGCCCCCTCCTGGCGACGGCCGGTGGCCCTGCGCCTGGTGCCCCTGGG
+GCCCAAGCAGGTGGCCCAGGCCCTGGACCGCCTGTCCGCCGCCCGCCGTCGCCTGCAAAA
+CCTGGGGCGCGGCACCCTGGGCCACTGGGCGCTCATCGCCGCGCTCACCTGCGGCCTGGT
+GCTCACCCCGCCCGGCACGCCCTCCAAGGCCACCCGGGCCGACGCCCCGCTCAAGCCCCC
+GCGTCCGGTGCTGCGCCACCTGGCCCAGGGCAGTCCGCTGACCCCCATCTACCAGGTGCC
+GGCCCAGGCCCGCCTGCTGGGCGACAAGGTGGCCCGGGGGTCTCTGGAGCTCAACCTGCT
+GCCTTTGCGCGGCCAGCCGGTGGCCGTGCCCCAGTCGGTCAAAAGACGCCTCAAGGAGCT
+GGCCCGCGAGGCCGGGCTCTCGCCCAAGGTGCTGCTCACCAGCGCCAGGGCGCTCTACGC
+CGGCCAGGCCGCGGTGGACCCCAGCGCCCTGGAGGAGCTGGCCCACACCGCCCGGCAACT
+GGCCCGGCGCCATCCCCTCATCTTCCGCGAGCTCTCCCGCCGCGGGCTGCCGCCGGCCGC
+CTCGGCGGTGGCCGCCCTGGCGCCCGAACCCGAGAAGGCCCAACATCTCTTCCTGGACCG
+ACTCTATCGCGAGTACCGCTCCCTGGGCTTCTCCGCCGAGGAGGCCCTGGGCGCCCTGGC
+CGCAAACCAGCGCGCCTTCCACCGCCTGACTCGCCAGTGGACCCCGCCGCGGCGTTTCAT
+CGGCAAGGTCCAGCCGGTGGAGGCGGTGGAGAAGATGGGCCTGCGGGAGTTCCTGCAAAA
+GATCACCCCCTACATCCAGTCCAAGCTCAAGGTCTTTCTGCGCCAGCGCGGCATGAGCTA
+CTCTGGTGACCTCACCCTCTACGCCAAGAATCTGGCCTTCGACATGTACTGCGCGGCCAA
+GAAGTTCCAGGTGCCGGTCACCCTGCTCTTGGCCATCGCCCACCAGGAGACCTGGTACGC
+CAACGTCCTGGGCGATGCCAACCGCTCGGCCAGCCCCTTCCAAATCTACGAACCCACCCG
+CGAGCTCATCATCAAGTCCATGGCCGAGGCCGGCTTCGTGCCGCCACCCAAGAGGATCAA
+GCTCCAGCGCCACCTCACCATGGCCACCTTCATGGCCTCCTTCCATCTGCGCGAGCTCAT
+GCAGCGGGCCTACACCCCGCCGCGCCGGGGACGCCAGGCGGTGGTCAACCTGGACCGGGT
+GCTCCAGCGCTACAACGGCTCCTCGCGCTACGCGGCCCAGGTGGCCCTGCGCAAGCGCCA
+ACTGGCCCGTTTCCTCCGCCGCCAGGGCTGAGGGGGCCAGGGAGGCGAGACCAGACGGGC
+GCGGGACGCGGGGAGCAGGCGGGAGACGCGAGCCGAGGGGGCAGACCGGGGAGAGACAAG
+GCGCCCCTGGCGAATCACCTGACGGCCACCGCGAGCAGGCAAGCGAGACGGCAGTGACGC
+GCCGGCCGGCGCGAGGCGCTAATCAATCCAACCCCCGCCGCCCGGGGCGGGGCGCTTCAC
+GGGAGGGAAGGGTGTCATGATCGGCAAGCGCATCAGGCTGGAACGGGTGATGGACCGCGG
+CACCAGACGCACGGTGCTGGTGCCCTTGGTGCACGGCGTGGGCATGGGGCCCATCGAGGG
+CATCACCGACGTGCTCAACACCGTGGACACCATCTCCATGGGCGGGGCCAACGCGGTGGT
+GCTCCACAAGGGCATCGTGGCCGCCGGCCATCGCCGCGGTGGGGCCGACATCGGCCTGGT
+GATCCACCTGAGCGCCACCTGCGCCGACGGCAGCCAGACCCTGGTCACCGAGGTGGAGGA
+GGCGGTCTGCCTGGGGGCCGACGCGGTGTCGCTGCGTATCGAGGTAGGCGGCGCCGACGA
+GGACGAGTCCCTGGCGCTGCTGGGTGCGGTGAGCCGCGTCGCGGCCGACTGGGGCATGCC
+GCTGTTGGCCCTCATGAACCCCGCCCCGATCCCACCTGCCAAAATGCCCAAGCTCCTCAT
+GCGGGCCGCCCGCATCGGGGCCGAGCTGGGGGCCGACGTGGTGCTGGTGCCCTACCACAA
+GCGCTTCGCCGAGGTGGTGGCCGCCACGCCGGTGCCGGTGGTGGCCATCGGCGGGGTGAA
+GAAGACCCCGCCCAAGCAGATGCTGGAGATGGCCCGGGCCGCGGTGGACGCCGGCGCCTA
+TGGGGTGAGCGTGGGGCGCACCGTGTTCCAGTACGAAAAGCCGGGCAACATGATCAAGGC
+CATCTGCCAGGTGGTGCACCGCAAGGCCACGGTGAAGAAGGCCATGGAGATCCTGGCCAA
+GAAACCCATCGAGAGCACCCTCTACGGCGGCACCGTCATCTGGTGAGAGGCCGCCGGGGG
+CTGCCTGGCTTGAACGCGCAGGCGGCGGGCCGGGGCCGACAGGCTCCGGCCCGTTTCTAT
+TTCTCCGGCTGCAAGGGCCGGCCCAGTTCCTCCAGCAAGGGCGGCAGGCCCTCTGGCTCC
+AGGGCGTGGATCCGCACCAGCAGCGCCTGCTGGCGCGAGGGCGGCAGCAGGCCGGCGGTG
+AGCGCCCGGAACTTCTCCTCCAGGCGGGCGGTGGAAAGGGGATTGGCCGGGTCGCCCAGG
+GGGTCCAGCACGGTGTGCTCGTGGCGGCGTCCGCTGCGGGTCATCGCCACCACCCGCGCC
+GGCGAGCGCTCCGGGAACATGGCCTCCAGCTCCGGGTCCACCTCCAGCCGCACCCGCCCG
+GCCAGCTCCACCAGATCCTCCCGTCCCAGCAGCTCCGGCCGCAGGGGCAAAAGCCCCGCC
+GCACCCTCCACCGCCGCCACCGCCAGGGTGAAGGGCAGGCTGTACTGGGCCCCCTCCAGG
+GTGGCCGGGCCGGTCTCGTTGCTGAGCCTCAGAGCGCGTTCGAAGGTATGGACCTGGATC
+TCTGCGATCTCGTCGGCGTCCAGACCCTGTTCGTCCTGGAGAGCCAGCAGGGCGTCGATG
+GCGGCGTGGCACCAGCGGCAGCAGGCATAGGGCTTGAAGTAGACCTGCTCGATGGCCCAC
+TGCCCGCCGCCCAGCCCGGCCGTGATGCCCGGGGCCTGGTAGTAGTCGGGGTGGTCCAGG
+ATGTCCAGGGGACCGCTGAAGCCGTGGGCGGCAAGCTTCACCGCCACCAGGCCGGTGAGG
+GTGGCCCAGGGGATGCCCTCCTTCACCAGGTTGCCCATGAGCCGGGAGTAGCCCGCCGCG
+GCCAGATCGGGCGAGAGCACCCCGGCCACGGCCATGGCCTGGGCCAGACCGGCGGCGTCC
+AGGCCGTGCAGCCGCCCGGCGGCCGCGGCCACGCCGTAGGCCACCCAGCGCCCGCTGGCC
+ATGGTGGGCAGCCGGGCCAGATCCCGCGCCGCGGCCACCCGGCAGGCCACCTCGTAGCCC
+AGCACCAACGCCGCCTCGAGCTCCCGGGCCGAAGCCCCGGTCTCCTGGGCCGCGGCCAGG
+CAGGCCGGGATAATGGCCGCGCCGGGGTGGCCGGCCGCCGCCCGATGCCCGTCGTCCAGG
+TCCCAGGCGCTGGCCGCGGCCGCGTTGGCCAGCGCCGCCCCGGGGGAGGCCAGCCTCCGG
+CCCGAGAACCACAGCCAAGCCGGGCCGGCGGCAAACAAAGGCCCGGCCACCGCCCGCACC
+ATGCGGGCCGCCCCGCTGCCGTGGCCGGCGCAGGCCGCACCCAAGAGATCGATGAGGCAG
+CGGTTGACGGCCTCGCCCAGCCGGGGCGGCAGCTCGTCCGCCTTCAGCCCGGCCGCGAAA
+CGGCCCAAGGTCTCCAGGGTGGTCAAGCTCCTTCTCCCGCGGGACGCAGCTCTTGCACCG
+CCTGCCAGGCGTCGAGGTCCACGGCCCCTTCCCGGGCCATGCGCTCGACCACGCGCCCCG
+CCGCCCGGCGCCAGGGCTCCAGGTCCACCTTCAGATACACCGCCCCGTACTCGGCCAGGT
+TGGCCGCCTGGTTGTCCACCTCGGCCCGGCGTATCTCAATGCTGAAGAACCCCCCGGCCG
+CGTCGCAGGATTCCTCCAGGGCGGCCTGCACCGCCGGCGGCAGGGAGAGGTACTTCTGCT
+CGTTTACCGTCACCGCCAAGGCCGGCGGCACGTCGCCCAGCAGGGTAACGAAGCGCCCCT
+GGCGGCAGAAGCCCAGCGGGTAGAGGTGGGAGCGGTGGGTGGGCAGCAGGTCGAACTCGC
+CGGCCTCCCAGGCCTCCCTGACCCGCGGCCAGGGCACCACCACCGGCCGCGCCCCTAACT
+CCTCCCAGAAACGGGCCAGGGCGGGCGAGTCGAAGATGCGGACCTTGAGGCCCTTCACCT
+CCTCGGGACGGGTCACCGGCTGGCGGGCCACCAGCACCCGCTCCAGGCCCCGGCGCCAGT
+TCCAGCGCCGGTTGAGGATGCGGATGCCGCTTTTGGTCAGCGGCCCGTGGACCCGCTCCT
+GGAAGAAGGGGCTCTCCAAAAAGGAGAGCAGGTGGGCGTCGTCGGCGAAGACGTAGGGCA
+GGGAGATCAGCTTCACCGCCGGGGCGATGTGCTGGTAGAAGATGAGTTCCTCGATAAAGA
+GGTCGATGACCCCCTGGCGCAGCATGGCCACCTGGTCGGGCGCCGAGCCCAGCATGGTGG
+CCCACAGGGGGATGATGGACATGCGCCCGCCGCTGCGGCGGTTGACCTCGGCCGCGAACC
+ACTCCAGCCCCCGGTTCTCCGGCCCGGAAACGGTGGTCATGGTGCCCAGCACCCGGGGTA
+TCTCCTCCTCCTTCTGGAAGAGGTAGCTCAAGGGGCGGTCCAGCACCCGGCAGAGGCTGG
+TCAGCACCGGGATGGAGATGGCCGCCTTGCCGTTCTCCAGCTTGGAGAGCTGACTCTGGG
+ATATCCCCGCCCGGGAGGCCAGCTCGGTGGCCCGCAGGTCCAAGGCCTGACGCAGCTCGC
+GGATGCGCGAGCCCACCATACGACGTATGCGTCTCTCGTCTTCGGACAAGCGGGCCACCG
+CTCTCTACTCCTCCTCCAGCCGCCGCTGCACCTTGATACCGCGCGCCGCCAGCTCATCCA
+AGAAGCGCTGGCCGTCCACCACCTTCACCGGCGAGAGCACCCCGGCGCCGGTTATCTCCC
+CCTTGAGGACCATCTGGGCCCCGATGCTGGCGGCGAAACCCACGGTGCGGTTCATGGCGA
+ACAGGCCGGTGGCCAAGTCGCGGTAGTCCACCAAGTCGTAGGTCACGGTGCGTTTGCGCC
+CCCCGCGGCGGCCCCAGACCTTGACCCTGAGCACCACCACGTCGCGCTCGTTCTCGCGGA
+ACTGCAAGCGCGGCTCCAGCAGCTTCACCAAAAACTCGCGCGGGCTGACGGACACCCCCT
+CGCCCAACTCCACCGGCTGGTCCCCCAAAAAGCCCAGCTTGGCCATGATACGCCAGAAGG
+CGCTGTGGCCGGGCCAGCGGGTGGCGAAGCGGCCCATCTCCTTCAGCTCCGGCCCCAGGC
+CGAATACCTCGACGAAGCGGGTGGCGTCGCCGTTGGGGTAGGCCTCCAGGCGCCCCAGCT
+CCGGCACCTCGATGAAGTGTATGTTCTCCTCCTGGAAGATCTCGTCACCGGGGATCTCCA
+CCGGCCGCCCCTGGCGCAGAAGCCGCGCCGGCCGGCAGTAGGCCTTGAGCACCCCGTCGA
+AGGTCCAGGTGATCTTGTACTTGAGCGGGTTGTCGCAGGCCGCCGGATCGGGCAGCCCGC
+CGCCGTAGCTGTAGAACCCCTCAACCTGGTCCAGCTCGTCCAGGGCCATGCGCCCCACGA
+TGAGGTCGATCCCCGGATCGAAGCCCATCTCGGGCAGCAGGATGACCCCCTTGTCCCGGG
+CCCGCTGGTCCAGCTCCCCCAGCCACTGGGCGTAGCTGGTGTTCACGAAAGGCACGCCGC
+ACTCCACGCAGACCTCGGCGATGCGCCCACTCAGGTGGGCCGGCAGCATGCAGACGACGA
+TATCGGATCGGTTCTCGCTTATCAAGCGCCTAAGCACCGCCGGGTCCAGGGCGTCGGCCT
+GCACGGCCCGAACCTTGTGATAACCGCCCTTGTCCAGAAAGCGCTGCGCGGCGGCCAAAT
+CGAGATCGGCCACCAGAATCCGGTCCACCAACTCACTGCGGGAAAGGTCGTGGATCACCG
+CCTTTCCCTGTAACCCGGCCCCAAGTACCAGAGCGTTCATCTTTACACTGTCTCCTGTGG
+CGTTGTGGATATCCCGGTTAGACATTCCTCAACCTGGGATCCAGGGCGTCGCGCAAGCCG
+TCGCCCAGCAGGTTGATGGCCAGGATGGTTAGCATGATGGCCAGACCGGGCAGGGTGACC
+>NODE_13_length_9239_cov_583.686_ID_25
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+CACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGTTGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCACCCGTGCCATTTCCTCCAT
+TGAAACGGACGGGAAGTTGACGGCGTTGGTAATCACCCCGTCGATAAGGCAGGCGGCCAT
+CTGCTCGGCGATCATGCGGGCCACCTTGACCTGGGCCTCTCCCGTACTCGCACCGATATG
+CGGGGAAAGAACCACGCGGGGATGCTTGAGAAGCGGAAGCGATGCATCCGGCGGTTCCTT
+TGGAAACACATCGATGGCCGCGCCGGCCACCCGGCCGCTTTCCAGCGCACGGTAAAGATC
+ATCTACGTTCACCACGTCGCCACGGGAACAGTTGATGATCCGGACTCCCGGCTTCATGCG
+GGACAGGGTGTCTGCGTTGATCATGTTCACGGTCTCTTTCAGACGCGGGACATGAAGTGA
+AATAAAATCCGATGCGGAAAAAAGTTCGTCCAGGGAAACCAGCCGCACATTGATTCTTGC
+CGCCGCATCGCAGCTGACATACGGATCGGCCGCAATTACCCGCATCTTCAAGCCCCTGGC
+CCGGTCGGCCACGATGCGTCCGACATGCCCCAGCCCGATGATTCCCAGGGTTTTGCCGGC
+GATTTCGACCCCGATGAGTTTTTTCTTGTCCCATGCGCCCTCCCGTAAAGAGGCGGTGGC
+CTGGGGGATATTGCGGGCCAGGGCCATCATCATCGAGACCGTGTGTTCGGCAGTGGTCAC
+CGTATTGCCGCCCGGTGCGTTCATGACAACGATTCCCTGGCGGGTCGCCGCCTCCAGATC
+GATATTGTCCACACCGATGCCGGCCCGTCCGATGATCTTCAGACGTCCGGCCTTTTCCAT
+GACCGCGCGCGTGACCTGCGTTCCGCTGCGGATGGCCAGGCCGTCGAACTCACCGATCAT
+CTCCGCCAGCACCTCCGGCGCATTGGCCGCCTTGTCGTTGTCCGTGACCACCTCGATCTT
+TCCGGTCGCCGTCAGTATTTCCCGTGCGACCGGAGACATGGAATCCCGAATCATGACCTT
+GAACATGTCGCCCCCACCAATATATAATGGTTAAATGCGGATGATCCCGATTCCATATAT
+TCAGAAACGCTCGGCTACGTCAAATTGAAATGATCCGGGACCGGCCTTTCCGGCGGATAA
+GCGTTGAAGAGTTGAATGAGGATATAAATGGGTGTATCGTAAATGTCATCCATCCGGAAA
+CCGGGGCATGCGCCTTCCGCAGGTATGTGCTCCAGCTTATTCCTCTTATAAAAGGAGGTA
+TTCCATGAACGACCCGATTTATCAAAAACTGGCCACCGTTTTAGACACACTCCCCAACGG
+ATTTCCCGCAACCGAAGACGGGAAAGAAATCCGGCTCCTGAAAAAAATTTTCTCCCCGGA
+GGAGGCTGAGCTCTTCTGCGACCTGAAATTGACATTTGAGACGGCCGAACAGATCGCAAA
+CCGAACGGCGCGCCCCGTGGAAGAGTTGAAAGCGCGTTTGTCCGTCATGCAGGAAAAGGG
+CCAGATTTTCGGCATCGATATGGGCGGGGTCGGTATTTACAAGATGCTGCCCTGGGCTTT
+CGGCATCTACGAGTTCCAGTTACCGCACATGGACCGGGAGCTGGCCGAACTGTGCGAGCA
+ATACGGCAAAACTTACGGGAAGCAGTTTTTCGCAAACAAGCCCCAGCTCATGCAGGTGGT
+CCCCATCGAATCCGAAATCAAGGCGGAGCATGAAGCCCTTCCCTATGAGCGGGTTTCCAC
+CATCATCGAAAACAGCCGGTCCTTCATGTATTTCGACTGCATCTGCAAGAAGGAAAAGGG
+ACTGATGGACGAACCGTGTGACAAACCCGTCCAGGTCTGTACCGCCTTTGCACCGATTCC
+CGGTGTTTTCGACGATCACCCGTATGGCAAAACCATGACAAAGGAGGAGGCCTACCAGCT
+CCTCAACAAGGCCGAGGAAGCCGGACTGGTGCACCTGACCTGGAACGTGAAAAGCGGCCA
+CTTTTTTATCTGCAATTGCTGCGGCTGCTGTTGCGGCGTATTGCGGGGCATCAACGAACT
+GGGAATCGATGCCTCAAAGGTTATCAACTCCTATTATTATGCGCAGATCGATGCGGAAGC
+CTGCGTCGCCTGCGGAACCTGCGCCGATGAGCGATGCCAGGTGAACGCCATCATGGAAGG
+GGATGATGCCTACACGGTTATCGCGGAGAAATGCATCGGCTGCGGCCTGTGCATCACCAC
+CTGCCCCGGCGACGCCATATCCCTTGTCCGTAAACCCGCAGCGCAGATCGAAACGCCGCC
+GGACGACGAAATGGACTGGTATGAGAAACGGGCGCAATTGAGAGGCGTCGACATCAGCGA
+TTATAAATAGTGCCCACCGGCAAATCATGAAGGATAAATTGGCTTAACATGGAGCTGACA
+AACGACGAAAGGGAATTCTTTGCGCTGGTCAACCGGGCCAGCCTGCTGAATCCATTCAGT
+GATGAACGAAATGACGTTGATCTGAAGCTGGCCGGTCTGCCGTCCGCAGCGCCCGGAACC
+GGACGGGTCAAAAAAGCCATCCAGTCGGTAAATGAGCGGATCCGTCAGCTTGAAACCGAC
+GGCCGGGCCGATATTTCACAATACACCGGCCGGGACCGCGAGCTTGTCGAAAAGGCGTTT
+CTCTTCGAGCTCTTTTATCGGTTCAGAAAACAGTTCGATGAACTCATTGAAAGCCAGATT
+GCGTCCGATGATGTTCCCGCCAGAATTCCCTTTTATAATGATGCCTTTTCCGCGATGCAG
+AAGCGGGGTTTTACCGAGGAGGATTTCCGCCGCTATTTCGCACTGGCCTTCCAGATCCGG
+CGTGCGTTCTATTTCATCGGCCGGAGCCTGGTGGGCAACAGCGCCAGCATGAAGTCCCTG
+CGGCTCAACCTGTGGAACAACGTGTTCACCCACAATATGGACCTCTATGACCGGTATCTC
+TGGAACCGGATGGAGGATTATTCGACCCTGATTCTGGGGGAAACCGGCACCGGCAAGGGG
+GCCGCGGCCCTGGCCATCGGCCGGTCCGGATTCATTCCGCTCAAGAAAAAAAGCTTCGAG
+GAGAGCTTCACCCGGTCCTTTATTTCCTTAAACCTGTCCCAGTTTCCCGAAACACTTATC
+GAATCGGCGCTTTTCGGCCATAAAAAAGGCGCATTTACCGGGGCAATCGAAAACTACCAG
+GGCATCTTTGAACAGTGCAGCCCCTACGGCGCCATCCTGCTGGACGAGATCGGCGAGGTG
+TCGAAACCCATCCAGATCAAACTTCTCCAGGTCATCCAGGACCGCGTCTTCACGCCGGTG
+GGAAGCCAGACCCGGAGCCGGTTCAACGGCCGGGTTATTGCGGCCACCAATCGTCCGCTC
+GAAACACTCAGGGGGAAGGGGTTCTTCCGCGATGACTTCTACTACCGCCTCTGCTCGGAT
+ATCATTGTCGTCCCGCCCCTGCGTCAGCGCGTCCAGGAAGACCCGACCGAACTGGATGTG
+CTGCTCGATTTCACCATCAACCGGCTGGTCGGCCGGTCATCGCCGGAACTGGTGCAGATC
+GTCCGTGAGGTCATCGACCGGCACCTGGGCAACGACTACCCCTGGCCCGGAAATGTCCGG
+GAACTCGAGCAGTGCGTACGCCGTGTCCTGCTCAAAGGGATCTACACCGGGGATGCCGCT
+GTCGCGGACATCGATCTGTGCAGGAGCCTGACAACCGGTATCGAACAGGGGAACATCGAC
+GCCAACAGCCTGACATCCGGGTACTGTTACCTCCTGTACCAGCGGCACCGGACCTTCGAG
+GAGGTCGCCCGCCGGACCGGACTGGACCGGCGGACCGTGAAGAAATATATCCAGGATTGG
+ACCAGCAGCCATTCAACTGACAATCCGCCGGAAACGGATATTCCGGGATAAACACCATTT
+TCGTTTTCATTCCCGCACCACCCCCTGTCGCCGCCGTTTTATTTTCTGTACCTGTTCTGT
+ACACGCCACCGACACAAACTGATGATTTCCGCTTTGAGAAAAAAGGGCCCGCGGCTGTCA
+TATTTTTTATTTTCATATAAAAAACAATATTTTAATCGTTTTTCAAAAAAGCTGGCATGA
+TGCTTGTAATATCAATAGACGGTTATTGTCGCAGTCGGATCGCAAAGCCATCCGCAATTG
+AAACCCGTTTTAAAATAAGGAGTGCATCATGAAAATCCAGCAGATCATCATCCGGGAATT
+TGAAGAAATGATGGCGGAACTCAAAGAAGTCCTTGCAAAAATGACCTGCCCGCTTCTCGG
+AGAAGACTGGCTCCCCATGTAGCCGCCGGCGGTTATCCGGGGATGGGCGGCCATCCCCGG
+ACGGCTGCGCTGCAGGCCTCCGCGGACGGCCTGCAACCCCTGCCCTTCAATCCACGCCCT
+GCCCGATCTCCTTTTTTTTATACGGGATGTTGAGTTTGTTCATCCGCTTCCGGAGCGTGT
+TGGGATTGATGCCTAAAAGCTCGGCCGCACCACCCGGGCCGTTTATTTTGCCATTGGTGA
+CTTTCAGCGCCCGCCGGATATGGATGGCATTCACCTCGTCGATGCTCAGGAACCGGTCGG
+TCGTCTCATGCCCGCCGCCCCGGGACGAGGCGATGGGGCTGAAGATCAGTCCGTCAAAAC
+GGAGCATCCCCCCCTTGAACTGGATCAATGCCCGCTCGACAATATTTTCAAGTTCCCGGA
+CATTTCCCGGCCAGTCATAAGCCATGAGCTGATCCATGGCGCCGGGGGAGAGCCGGGGCT
+GTTCCTGCATCTTAAGATCGATCGTCTTCTTTTCGATAAAATGATGGACCAGGGCCGGTA
+TATCCTCTTTCCGCTGCCGCAGCGGCGGGATGTGAATCGGAAACACATTGAGACGAAACC
+AGAGATCCTCCCGGAATTTACCGGAACGAATCATCTCCTCCAGGTTCCGATGGGTGGCCG
+ATATGATCCGGACATCCACGGAAATGGGCGTCGTTCCGCCGACCCGCTCGATGATTTTTT
+CCTGAAAGACATGCAGGAGCCGGACCTGGGCATGGGGCGGGAGCTCGCCGATTTCATCCA
+GAAAGATGGTCCCCTTATCGGCCCGCTCGAAGCGTCCCTTCTTCTGGGCAATGGCCCCGG
+TAAACGCCCCCTTCTCATGCCCGAAAAGCTCGCTGTCGAACAGGGATTCCGGAATAGCAC
+CGCAGTTGACGCTGACAAACGGTGCATTCTTCCGGGGCGATGCGTCGTGAATGGCATGCG
+CCACCACGCCCTTTCCCACACCGGTTTCGCCTAAAAGCAACACAGGGCTGTCAAGCTGCG
+TGACCTGCTGCACCATTTCCATCACGTGCCGCAACCCCAGGTCGGCGCCGACAATTTCGG
+AAATCGATAAATCCCGGATCTGGCGACGCAGGTAACGGTTGTCATCCGTCAAGATGTCCT
+TGAGGCGGATCAACTCCTGGTGCTGCAATGCATTGGTCATGGCAATGGCAAACGGCTCGT
+GCAGCAAAAGCATCAACCGCGCATGCTTCTCCTCATACCGGTCCCGCCCCCGGGTCCGGA
+GCAGCAGCAGCCCGACCCGCTTCCCTTCCAGTTCCAGCCGCATCGACATGAGGGAAATAT
+CGTGTTCCAGGCCGTACATTTCGATAACCTCTTGAATCTCCGGCCGTTCTTCCACCCGAT
+TGATGATCGTGATATCTCCCATGTCCGCCCAGATGGCCGACCACTTCTCCTTGCTCGCTT
+CGGGCAGGGGAGATACCGGGCTGAATTCATTTTTCCCGTGGCTCTTGACACCGGCGATCC
+GCTGAAAGACGTTCAGGCCCGGATCATAGAGATAAAGCCCTATTTCATCGACCGGCAGCA
+TCTGTTCCAGGTAGTGAAAGCAGCGCTCCAGCGCCGTTTCGATATCCAGGCTCCCGCAGA
+TCCGGATCGTTGCCTGCCTGAAAAATTCATTTTTATCCACAGCCATATCGCTTTCCCTCC
+CATCCGTTTTCTCACACCAAACCAGAAATACCCCATAGGATAACGATGGTCCTATTTTTA
+CACTATACGACAATATATTTTATCCCATAGCACAATCAAAAAATCAATATTTTTATAACC
+AACTGATATTCAACAATTTAAAAAGTTGGCACACTTTTCGCTATTATCTGACAATAAAAC
+GTCAAGTTGATGCATTAAAAAATGGGATCGGCCACGGCCGGAAAAACCCTTAACCCGATT
+TAGAAAGGATATAACGATGCGATTCAAAACACTCAAGTACATCCTGGTCCCGGTACTGGC
+AATCGGACTCAGCGGATGCGCCAGCACATTGACTTTACTCAGCCCGCCGTCCTCCCGGCT
+GGTTCAGGGGAAGAATACGGCCGGTGCGTTCAACAGTTACGAATACCAGTACGCCGTCCG
+CGGCAACAAGATCTATATCAAGCGGACACCGCTGTGCGATGAAGTAAAGCATGTGATGCG
+GGTGGAACAGAAGCGGGAAATCGGCTATGGCCCGGCGCTTCTGGAGCTGCCGCTGTTCGG
+GCTGGGACTTGTCGACATTGCCAATGCCCATGCAATCTCCGTTAACAGCAAAAAAGTCAC
+CCCGCTTGCCGATTACAACACCGGGAAATTGATGGCCTGCGGTCCGCTGCAGCCCGCTGC
+GAACGAGAAAGTGATTATCGAAAACAAGAATTTGAACCTTTACCGGATGGTCAGGACGGA
+TAAAAACGGTGTGGTGAACTTAGACAAGGTCCTGTCCGGCATCGGAAACAATGTCAACCT
+CAGTGTCCGACTGGCGAACAACCATAATGTGGCGTTTTCCTGCATGTACATCGCAAACCG
+GTAGTCGCCGCCGGATCGTGGTCTAGGTGTCGTTGTACGTGGGATCCCCGGGTACCGAGC
+TCGAATTCGCCCTATAGTGAGTCGTATTACAATTCACTGGCCGTCGTTTTACAACGTCGT
+GACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCC
+AGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCTGA
+ATGGCGAATGGCGCCTGATGCGGTATTTTCTCCTTACGCATCTGTGCGGTATTTCACACC
+GCATATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGCCCCGAC
+ACCCGCCAACACCCGCTGACGCGAACCCCTTGCGGCCGCATCGAATATAACTTCGTATAA
+TGTATGCTATACGAAGTTATTAGCGATGAGCTCGGACTTCCATTGTTCATTCCACGGACA
+AAAACAGAGAAAGGAAACGACAGAGGCCAAAAAGCTCGCTTTCAGCACCTGTCGTTTCCT
+TTCTTTTCAGAGGGTATTTTAAATAAAAACATTAAGTTATGACGAAGAAGAACGGAAACG
+CCTTAAACCGGAAAATTTTCATAAATAGCGAAAACCCGCGAGGTCGCCGCCCCGTAACCT
+GTCGGATCACCGGAAAGGACCCGTAAAGTGATAATGATTATCATCTACATATCACAACGT
+GCGTGGAGGCCATCAAACCACGTCAAATAATCAATTATGACGCAGGTATCGTATTAATTG
+ATCTGCATCAACTTAACGTAAAAGCAACTTCAGACAATACAAATCAGCGACACTGAATAC
+GGGGCAACCTCATGTCCGAGCTCGCGAGCTCGTCGACAGCGACACACTTGCATCGGATGC
+AGCCCGGTTAACGTGCCGGCACGGCCTGGGTAACCAGGTATTTTGTCCACATAACCGTGC
+GCAAAATGTTGTGGATAAGCAGGACACAGCAGCAATCCACAGCAGGCATACAACCGCACA
+CCGAGGTTACTCCGTTCTACAGGTTACGACGACATGTCAATACTTGCCCTTGACAGGCAT
+TGATGGAATCGTAGTCTCACGCTGATAGTCTGATCGACAATACAAGTGGGACCGTGGTCC
+CAGACCGATAATCAGACCGACAACACGAGTGGGATCGTGGTCCCAGACTAATAATCAGAC
+CGACGATACGAGTGGGACCGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGG
+>NODE_17_length_5536_cov_76.8441_ID_33
+TTTTTCAAGCAGAAGACGGCATACGAGATGCGCAGGAGTCTCGTGGGCTCGGAGATGTGT
+ATAAGGGAGAGGGATTCGAACCCCCGGACCTTTCGGTCAGCGGTTTTCAAGACCGCCGCC
+TTCGACCACTCGGCCATCCCTCCAACACCCCCCTATCTACCATCGGAGGGGGGGATAGTC
+AACTTGAGGCGGGCGGGGAAAAGGCCGAGATGAAGGGGTGAATCAAGCGGTTGACCTCGG
+CGTGGCGCTCCAGGTTCACCATGTGCCCGGCCCCGGCCACGATCTCCAGCCGGGCGTCGG
+GCAACCGCTCGGCCAGGAAGCGGCCGTACTTGGGCGGGGTGAGCTGGTCCTGGTCGCCGT
+AGATGAGAAGCGTCGGGGCGGTGATCTCGCCCAGGCGGTCGGTTATGTCGTAGCGGTCGC
+AGGCGGCGAAGTCGTCGTGGACCACCCGGGGCCCGGGCTGGCTCATGATCTCGCGGCCGG
+CCTGGACCCAGCGGGGGTCGGCGCCGGGGGCGTAGGCGTATTTGAGGACCAAGTCCAGGG
+TGGCGTCGAAGTCGCTGAGCAGGCCGTCCAGGATGGCGGGCAGGACCCGCAGGCGGGAGC
+CGGTTCCCACCAGGACCAGGGCTGGTGCCAGGTCTGGGTGGTCCAGGGCCAGTTGCATGA
+CGATGGCGCCGCCCAGGGAATGGCCCAGGAGTGCGGGGCGCAGGGGTCCGCGCCGGATGA
+ACTCGGCCAGCCAGTCGGCGTAGTGGGCCACCTGGTCGCGGCCGGGTCCGGGGGTATTGC
+CGTGTCCGGGCAGGTCGATGGCGGCGGGGTTGAGGTATGGGGCCAGGCCGCTGAGCTGGG
+GGCGGAAGGTTTCGCCGCGGCCGCCGGAGCCGTGGACCATGAGCAGGCAAGGCTTGTGGG
+GGTCGAAGGGCCGGGGCCCGGTCTCCAGGCCGATCTTCCGGCCGGCGATGTGTTCTTGCC
+ACATGGGGCGCGTCCTTTCGCTGGTGGTGATGGTCATAGGTTAATGCGAAACCGGGCGAA
+GTCAACGGGGAAGGGGGTGGAAGGACGGTGGGCTTTGGGGTTATGATGTCGGGCGCCGCC
+CCGCCATCCCACCGCGAGGCAGAACTATGAGCGAGACACCCCGCCGTCCCCGGGATAGCA
+GGTACATGTGGAGGGGCATACGTCCCAGCGAGGAGGAGCTGAAGACCATCCTGGAGGACC
+ATGCGCAGTGGCTTGAGCGGCTCCGATCCTGGGAGTACTCCTGGCGAGAATTCATAGAAG
+AAATTCCTCCTCCCCACGACCTCTCCGGCGCCGACCTGCTCGAGGCCGACCTCTCAGACG
+CTGACCTGACCTGGGCCAAACTCTCAAACGCCATACTGTTCGAGGCAGACCTCTCAAACG
+CCGACCTGCGCGAGGCAGACCTCTCAAACGCCAAACTGTGGTGGGCCGACCTCTCAGACG
+CTGACCTGACCTGGGCCAAACTCTCAAACGCCAAACTACTCGCGGCCGACCTCTCAAACG
+CCGAACTGTGGTGGGCCGACCTCTCAAACGCCAAACTGATCAAGGCAGACCTCTCAAACG
+CCGACCTGACCGGGGCCGACTTGTCCAACTGCGATGTGACTGGGGTGCGATATCATGGCC
+CCTGGCTTGGGATACCCTTCATCCAGATACGGAAGCCCAATAAACTCACGTGCCGCGGCA
+TCCGGGCTGACACCTGCTACGGCAGTCCGCGCTTTCGGCGCGACGTTATGGACCAGGACT
+TCCTGGAGGAGATGCGGGAGACCACCGGCGGCAGGTGGCTTTACCGCCTATGGTGGCTCA
+CCTCCAACTGCGGGCGCAGCTTCATCCGCTGGGCATTTTTTTCACTGTCTTTGGCGGTTG
+CCTTTGCCTGCGTCTTTTGTTCCAGCCTGGGGCCGGAGTGCTTCGACCTGCACCGGGCGG
+AGGGGAGCCGCTGGGTGGCGGAGGTGGCCGGCAGGTACCTGGAGGTTGACCCGGCGTACC
+TGGGTACCACCGCCGCCTCGCGCGGACTGCCGGGGGACTTCTGGACCATGCTCTACTACA
+GCCTGGTCACCTTCACCACCCTGGGCTTCGGCGACGTGGTGCCGCTCACCCCCTGGGCCG
+CCTTCTGGGTCACCATAGAGGTGGTGACAGGCTACATCATGCTGGGAGGACTGGTCTCCA
+TCCTGGCCAGCAAGATGGCGCGCCGCGCGGGCTGAGCAGGGGCCTGGACCCAACCAGCGG
+CCGCCTTTACTAACCCTGGCCGGGCATGCTAGCTTTGCCACATCGTTACTACCAGGGGGG
+AGTGGGGAGGTTTCGCCATGCGCGCCCGGTTGTTCAAGTGGGCCGGGGTGTTTTTCCTGT
+CGCTTGCCATGGCCGGCCCGGCCTGGGCCGCCAGTCGCGCCACACCGCACCGCCGGCCGG
+TGCTCAAGCTGCACTTCGCGGACGTGTCCTATGACTACGAGCTGAAACGGGCCATGAGCT
+ATGCGGTCAGCGGCGGTGCGGACATAAACGAATGCCTCACGGCCGCCCGGGCCATCACCG
+CCGGCGACGGCGAGAGCTGGTACCGCGGCTGGCACCGGATGGCCCGGCGCCTGGACCAGA
+TGGCCGACCAGGCCCTGAAGGCCGGCCACCGCCAGACCGCCCGCCAGTTCTGGCTGCGGG
+CCAGCAACTACTACCGCGCCGCCGAGTTCTTCCTGCACGGAAACCCCAAAGACCCCCGCA
+TACTGAGTGCCTGGGGGGCCAGCCGGCGCTGCTTCCGCCAGGCGGCCCGGCTCATGGACC
+ATCCCGTGGAGGTGATCGCCATCCCCTACGAGGGACACAAGCTGCCCGGCTACCTGGTCA
+AGCCCGACGCCTCGCTAAAGCCGCGCAAGACGCTGCTCCTCCAGACCGGCTTCGACGGCA
+CCGGCGAGGAGCTCTACATGGAAGTGGCCTGGTACGCCATCCAGCGCGGCTACAACGTGC
+TCATCTTCGAGGGCCCCGGCCAGGGCGGCGCCCTGCGCGAGCAACACCTCTACTTCCGGC
+CCGACTGGGAGAAGGTGGTCACCCCGGTGGTGGACTACGCCCTCACCCGCCCGGAAGTGG
+ACCCCAAGCGCCTGGCGCTCATGGGGCTCAGCATGGGCGGCTACCTGACCCCCCGGGCCG
+CGGCCTTTGAACACCGCCTGGCCGCCCTGGTGGCCGATCCCGGCGACTTCGACATGATGG
+TGGGACACCGCCCCACCCCCGCAGAGTGGGCCGGCATGAAAAAGTATCCCAAGCAGGCCA
+ACCAGGCCCTGCGCGCCAAGATGAAGCACGACACCGGCTTCCGCTGGCTGGTCAACAACG
+GCATGTTCACCACCGGCCGCAAGACGCCGCTGGCCTTCCTGGAGTTCTTCAGCCGCTTCG
+AGCTGACCCCCAAGATCGCGGCCCAGATCAAGTGCCCCACCCTGGTGGTGGTGGGCGCGG
+GGGATCACTTCGCCAGCCCCAAGTGGCAACGCCTGCTCTACGACAACCTCACCGCCCCCA
+AGACCCTGCTGCGTTTCGGGCCGGACAACCCCGCCCGCCAGCACTGCCAGGTGGGGGGCC
+TGCTTTGGGGCAACGCCAAGATCTTCGACTGGCTGGACCAAGTGCTGCGCTGAGCGCGGC
+CAGGGCCGCCGCGGGGAACCAGGCCAAAAGACCACCGGCCGGGAGGGACGCCCTCCTGGC
+CGGTGTCATGTCTGTACCACAGGCGGGGGGAAGCTCAGCGCACCACGCTGCCGGGGGGCA
+GCTCCTCCTCGGGCGCCACCAGGCGCACCCTGCCTTCGGCCACGCAGGCCAGCACCATGC
+CCTGGCTGATCTCGCCGCGCAGCTTGGCCGGCTTCAAGTTGGCCACCACCACCACCTGGC
+GGCCCACCAGCTCCTCGGGGCGGTAGTGCCGGGCGATGCCGGCCACGATCTGGCGGGGCT
+CGGGCTCGCCCAAATCCACCTTGAGCTTGAGCAGCTTGTCGGCGCCCTTGATGGCCCCGG
+CCTCCAGGACCCTGCCCAGGCGCAGCTCCACCTTGGCGAACTCGTCGATGGTGATGAGCC
+CGGCCTTGTCCTGGGGCTTGGCCTTCTGCTTGCCGCCGCCCTTGGCCGCCGGCTGCTGCT
+GGGCCTGCTTGGCCTCCTTGCGGGCGGCCTTGGCCTTGACCTTGTCGGTCTGCACCCGGG
+GAAAGAGCGCCTGGGGCTTTTCAGCCTTGGCGCCGGGGGTCATGAGCTCCAGGGCGAACA
+ACCGCTGCCAGTCCACCGGCACCACAAGCTCGAGCCCCAGCATGGCGGCCATCTTCTCGG
+CGGTGGCGGGCATCACCGGCCAGGCCAGGTGGGTGACCGAGGCCAGAAGCTGCACCAGGA
+TGTACAGCACGTTGTCCAGCTCGGCGGCGCGGTCCGGGTCCTTGGCCATGACCCAGGGCT
+CGCGGGCCACGATGTACTTGTTGGCCCGGCGCACCTGGCTCCAGAGGTCGGCCAGGGCGG
+TGTGGAAGCGGAACTCGCGCACCTGGGCCTGGAAGTCGTGCTCGGCGCCGGGGCCCAGGG
+AGGCGGCCAGGGCGCCTTTCATCTCCCGATCGGCCTCAGTGAGCTCCTGGGGGTGCAGCT
+CCGGCAGCAGGCCGTCGCGGTAGCGCGAGAGCATGTTCAGCACCCGGGAGAAAAGGTTGC
+CCAGGTCGTTGGCCAAATCCGCGTTGTAGCGCTCCACCAGCAGGTCCTCGGAGAAGGAGG
+CGTCCAGGCCGAAGGTCATCTCCCTGAGCAGGAAGTAGCGGAAGGGGTCCACTCCGTAGA
+TGCCGGCCAGGTCCAGGGGCTTGACCACGTTGCCGCGGCTCTTGGACATCTTGCCCTCGC
+CCACCTGCCAGTAGCCGTGCACGTTGAGGTGGCGGTAGAGGTAGTGGTCCAGGGGCCGGC
+CCTCGGCCTTGGCCAGAGCCATGAGCATGGTGGGCCAGTAGATGCCATGCGGCTTGAGGA
+TGTCCTTGGCGATGAGGTGCTGGGGGTCGGCCTTGGGTCCGGTCCAGAAGCGCTCCAGCA
+GCTCGCCGTCCGGCCAATCCAGGCCGGAGAGGTAGTTGATCAGGGCGTCGAACCAGACGT
+AGGTGACGAAGTTCTGGTCAAAGGGCAGCTCGATGCCCCAGGTGAGACGGGTCTTGGGCC
+GGCTGATGCAAAGGTCCTCCAGGCCCTGGTCCAGTATGGCCAGGACCTCGTTCTTGTAGC
+GTTCGGGCCGGATGAAGTCGGGGTTGGCCCGGATGTATTCCTTGAGCGGCTGGGTGTAGT
+CGCTCATGCGGAAGAAGTAGTTCTCCTCCTCCTGGTAGACGGGCTCGGTGCCGTGGTCGG
+GGCACTTGCCGTCGATCATCTCGTGTTCGGTGAGGAAGCGCTCGCAGCCCACGCAGTAGT
+GGCCGCCGTACTTGGCGAAGTAGATGTCGCCGGCCTCGTGGACCTTGCTGAGTATGGCCT
+GCACCACCTGCATGTGCTGGGGGTCGGTGGTACGGATGAAGTTGTCGAACTGGATGTTGA
+GCTGGGGCCAGAGGCTGCGGAACTTGCCGCTGATGCGGTCGGTGAACTCCTTGGGCTGGA
+TACCTTCCTTGGCCGC
+>NODE_1_length_50014_cov_374.697_ID_1
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+NACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGTTGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCACACATCTTTCGTTCGGGTG
+ATCTGCGTCGTCGGCTGATGTTTCTGGCCGGCGCGCTGATCGTGTTCCGTATCGGGATTC
+ACGTGCCCGTACCGGGCGTCGATCCGACCGCCTATGCGCACCTGTTCAATCAGAATGCAG
+GTGGCATTCTGGGGATTTTCAATGTCTTCTCCGGTGGTGCGCTGGAGCAGATGTCGATCT
+TTGCCTTGGGGGTTATGCCCTACATATCGGCCTCGATCATCATTCAGATGCTCACTTCGG
+TAGTGCCCAGTCTGGAAGCCTTGAAGAAGGAAGGTCAGGCGGGTCAGCGCAAAATCACCC
+GTTATACGCGCTACTCCACAGTTGCGCTGGCCCTGTTCCAGTCGCTGGGCGCAGCATTTG
+CGTTACAAAGCCAGGGGGTCGCATTGACAGCGGGACCAGGCTTCATCGTTACAGCTACCG
+TCAGTCTTGTCACGGGCACCATGTTCCTGATGTGGTTGGGTGAGCAGGTGACCGAACGTG
+GCCTGGGCAATGGTATCTCGATGATCATCTTCGCGGGTATCGTGGCCGGGCTGCCTTCAG
+CTATTGCCAGCACTCTGGAGTTGGTGCGCAACGGCGAATTATCCTCGATCGTGGCCATCC
+TCATTTTCGTGGGCGTATTGTTGATCACTGCTTTTGTGGTGTTCGTGGAAAGCGGACAGC
+GACGCATCACCGTGAATTATGCCAAACGCCAACAGGGGCGTCGCATGTACGCGGCTCAAA
+CCAGTCACTTGCCGCTCAAATTGAACATGTCGGGCGTGATTCCGCCTATTTTTGCCTCCA
+GCATCATCTTGTTCCCGGTTACCCTGGCGGGATGGTTGGGGCAGAGTTCTGGCTTTGGCT
+GGTTGAACACTTTGCAGTTATGGCTTTCGCCTGGGCAGCCCTTGTATGTGGCTCTGTTCG
+CAGTGTTGATTATATTCTTCACATTCTTCTACACCGCGCTGACGTTTAACAGTGACGAAA
+CCGCGGACAATCTGAAGAAATCCGGCGCGTTTATTCCGGGCATCCGGCCAGGCAAGCAGA
+CAGCAGGCTATATAGATACCGTGCTGACGAAACTGACTTTGTGGGGCGCGTTGTATCTGA
+CGGCAGTCTGTCTGTTGCCGGAATTCTTAATTGCTTACGCACACGTATCGTTCAACTTCG
+GCGGTACGTCACTTTTGATTGTCGTTGTCGTGGCGATGGACTTCATGGGTCAATTGCAGG
+CCCACATGATGACGCACCAGTACGAAGGATTGCTCAAGCGGGCCCGCATGCGCGGTTTGC
+AGAGGTAGTCGGGAGTTAACAATGAAGGTAAGGGCTTCGGTCAAGAAAATTTGCCGCAAT
+TGCAAGATCATCCGCCGCCGTGGTGCGGTGCGCGTGATCTGCTCGGATCCGCGGCATAAG
+CAACGCCAGGGCTGAGTCGGCTTGAGTCGACGGGTTTCTGTTGTTAAAATGAACAGTTCA
+CTTCGCGATTCTTTTGAATTGCGCTGAGAGATAAGTAATGGCACGTATTGCAGGTATCAA
+TATTCCGCCGCACAAGCACACGGTGATTGGCTTGACGGCAATCTATGGCATCGGACGGAC
+CCGAGCAGCCGAAATTTGCGCCACGGCTGGGGTGGACCCGACTCGTAAGGTCAAGGACCT
+TTCCGAAAGCGAGCTTGAAGCCATCCGTCAGGCGCTGACCGCTTACAAGCTCGAGGGCGA
+TTTGCGCCGTGAGCTCAACATGAACCTGAAACGATTGATGGACCTCGGTACTTTCCGTGG
+TATCCGTCACCGTCGTGGGTTACCGGTGCGTGGTCAGCGGACCCGTACTAACGCCCGCAC
+GCGCAAGGGTCGCGTGCGTCGTAGCGCCAAGCGCTGAAGATTTCCGGAGAATACTGATTC
+ATGGCAAAACCGGCGGCTAAAGCGCGTAAGCGCATCAAGCAACAGGTGGTGGATGGCATC
+GTGCATGTGCATGCGTCGTTCAATAACACCATCATCACCATTACCGATCGCAAGGGTAAT
+ACGCTCTCGTGGGCGACAGCTGGTGGCTCGGGCTTCCGGGGATCGCGCAAATCCACGCCG
+TTTGCTGCGCAGGTGGCTGCCGAACGTGCTGGTGCCGTGGCCCAGGAGTACGGGGTCAAG
+AACCTGGAAGTCGAGATCAAGGGGCCGGGGCCGGGTCGCGAATCTGCTGTACGTGCATTG
+AACAATCTGGGGTTCCGCGTGTTGTCGATTTCCGACGTGACACCGATCCCGCACAATGGT
+TGCCGGCCTCCCAAGAAGCGCCGGGTTTAATTAGGGGATTTGTAAAAAATGGCACGATAT
+ATCGGTCCCAAGTGCAAGCTGGCACGCCGCGAGGGTACGGATCTTTTTCTGAAGAGCCCG
+ATCAAGGCACTTGATCAAAAGTGCAAAATTGATCGGATCCCCGGGCAGCATGGTCAGGCA
+ACCCGTCGTGGTCGCATGTCCGATTATGGTTTGCAGCTGCGCGAAAAACAGAAACTGCGC
+CGCATGTATGGTGTGCTGGAGCGCCAGTTCCGACGTTATTACAAGGAGGCTGCGCGCCGC
+AAGGGTGCAACCGGTGCCCTGTTGTTGCAGTTGCTGGAGTCTCGTCTGGATAACGTAATT
+TATCGGATGGGCTTTGCCTCCACCCGGGCTGAAGCACGTCAATTGGTCAGCCATAAGGGT
+GTAACTGTCAACGGTCAGCTAGTGAACATCCCGAGCTTTGAAGTGAAGGGTGGGGATGAA
+GTTGCACTGACTGAGCGTGCGCGCAAGCAGAATCGCGTGGAAATGGCGCTGGAAATCTCA
+CGCCAGATCGAACGGCCCGCTTGGGTCGAAGTCGATGAAAAGGCGTGCAAGGGCACCTTC
+AAAGCTATGCCCGAACGCGAAGAACTTTTGCCAGATATCAACGAAAATCTGGTTGTCGAG
+TTGTATTCGAAATAAACGTCGAGGTTCGAACACATGGAAATTTCCGTATCCGAGTTCCTC
+AAGCCGCGTATTGCCGGTTTGACCGAGCTGGGTGAAAACCGTACCCGCATCGTTCTGGAA
+CCCTTGGAGCGCGGCTTCGGCTATACGCTTGGGAACAGTCTGCGCCGGGTTTTACTGTCC
+TCGATGCCTGGGGCTGCTGTAGTAGAAGCAGAAATCGATGGCGTGCTACATGAGTACACC
+GCCATTGACGGCGTGCAGGAAGACGTAGTTGAAATCCTGCTCAACCTGAAGCTGCTCGCC
+ATTCGCATGCATGCCCGTGAAGAAGCCACGTTGACTCTGAACGCAACGGGTGCGGGCGTC
+GTTACGGCTGGCGACATCCAGGTTGATCACGATGTGGAAATCGTCAATAAGGATCTGGTT
+ATTGCCCACTTGGCGAAAAACGGCAAACTGTCAGTGCGTCTCAAGGTGATGCGGGGACGT
+GGCTATATGCCAGTGGTCAAGCGCTATGCCGACGAATCCCAGGGGCGCAAGATCGGTAAG
+CTCAAGTTGGACGCCACGTTCACACCCATCCGCCGTGTGGCCTATTACGTTGAGGCTGCG
+CGCGTCGAACAGCGTACCGATCTGGATAAACTGATTCTGGATATCGAAACTAACGGTACG
+ATTGGTGCCGAAGAAGCTCTGCGTCGCGCAGCAGGCATCCTGACTGACCAGCTTTCGGTG
+TTTGCCGATCTTAGTTCGGTCAGCTCGCATACGCCAACCGAGAGCCGCAGCGTCAAGCCG
+ATCCTGCTCAAGCCGGTTGAGGAACTTGAATTAACCGTACGGTCTTCTAACGCCCTGAAA
+GCCGAACGTATTCGTTTCGTTGGAGATCTGGTGCAAAAGAGCGAAGACGAGCTGCTCAAG
+ACGCCAAACTTGGGGCGCAAATCACTGACCGAAATAAAAGATGTACTGGCCCGCCATGAA
+CTGGCGCTCGGAATGAAACTTGAAGACTGGCCCCCGGCAGCGCTTGCCGAGCGGCGCGCT
+TCCTGAGGAGGTAACTGTTATGCGTCACCGTAATTCAGGTCGTGCGCTCAGCCGCACCAG
+TTCTCATCGCGCTGCCCTGATGCGCAACATGAGCAAGTCACTAATTGAGCACGAACAGAT
+TCGTACCACCGTGCCCAAGGCCAAAGAATTGCGTCGGGTTGTGGAGCCTTTAATCACGCT
+GGCAAAGAGCGATAGCGTGGCGAATCGTCGTTTGGCGTTCAGCCGTTTGCGTGACGATGC
+CATCGTGGCTAAGCTGTTCACCGACCTCGGCCCGCGCTACCGCGAACGTCCGGGCGGCTA
+CCTGCGCATCCTGAAGGCGGGTTTCCGGCCGGGCGACAATGCGCCCGTGGCAATCGTCCA
+ACTGGTGGAAGAGCAAGAAACCACATCCGCTGCCACCTGAGCGCACCATGCGTAAGGTGC
+GGGTAGCCATTGTCGGGGCCGGTACTGCCGGACTTACCGCTCTGGCCCAGGTGAGGCGCA
+GAACCGACGAATTCGTCATCGTCAATGATGGGCCCTATGGCACGACCTGCGCCCGTGTGG
+GGTGCATGCCTTCCAAGGCGCTGATACACATCGCGAACGATTTTCATCGCCGTCGCCGCT
+TTGCGGAAGTCGGCATCGCGGAGGGCGAGACGCTGCGGATCGATCTGTCCAAGGCCCTCG
+CCTGGGTACGTGCTTACCGTGATTCACGAACAGCCGACAGCATCAAGCTTACCGACCCGC
+TGGGCGAGCGCAACATACCCGGACGGGCCGAGCTGCTCTCCGCGCATGAACTGCACATCC
+GGCGCGCCGATGGTGGAGAGGAACGCATCGCAGCCGATGCGGTGATTCTTGCCCCTGGTT
+CGACGCCGGTGATTCCGAAAAGCTGGGACGGTTTTTCCGCGCGCATATTGACTACCGATA
+CGCTGTTCGAGCAGCGCGATCTGCCGCGGCGCATGGCCGTTCTCGGGCTCGGCGCCATCG
+GCCTCGAAATGGGGCAGGCGCTCGCACGGCTCGGCTTGCAGGTACACGGCTTCGAGCTGC
+GAGATCGCCTTGGAGCATTGACCGACCCGCAACTCATCGCGCCGGCAATCGAGCACTTCT
+CCCGCGAATTCGATCTGCATCTTGGTGCGCCTGCCGAGTTGCACCCGACTGGCGAATATT
+GGCGGGTCGAAACCGCGGACGCACAGGTGGAGGTTGATGCGGTACTGGCCGCTTTCGGGC
+GCCGCCCGCGTCTCGACGGCCTGGGTCTCGAACGTCTCGGCGTTCCGCTGGACGCAAAGG
+GTCTGCCACCGGTTGATCCCCATACCCAGAGAGTAGCGGACCTGCCGATTTTTCTGGCGG
+GCGATGCCAACGCGCGCAGCCCGATCATGCACGAAGCCTCGGATGACGGCTATATTGCCG
+CAGTGAACGCCCTGGACGGGCCGACGCCTCTGAATCGGCGGGTGCCACTGGTCATGGCGT
+TTACCGATCCCGAAATGGCTATCGTGGGCGCATCGTTCGAATCCTTGCCCGCCGGCAGTT
+TCGATGCTGCGGGATACGATTTTTCCCGCCAGGGCAGGGCGATAGCCATGCGCCATGCCG
+AAGGGCGGCTGCGCGTGTATGCCGAGCGTAACAGCGGACGATTGCTGGGCGCGGAGATCT
+TCGCGCCGGAAGGCGAGCATCTTGCCCATCTACTCGCGCTGGCCCTCGATCGCGGGCTGA
+ATGTGGCGGAACTGCTGCGCATGCCCATCTACCATCCGGTCCTCGAAGAAGGCCTGCGCT
+CCGCCCTGCGTGCCTTGGCGCGCAGGGTTTACGACCAGCCTCCCCAGGAGTTTCGTCGCT
+TGCCTGAGGGGTGCCCAGGCATGTCTTCATCCTCTCCATGAATCCCTACGAACGCTACCT
+TCTGCCCTGGCTCATCGATGCAGTCTGCGCCTTGCCGGCAGCGGCCCGCGAGCGCGCCAA
+GATCGTGCCCCGCGCCCGGGGCGAGGTGCTGGAAATAGGCATCGGCACTGGGCACAACCT
+GCCCTATTACGCCCCACGCCGGGTTGCGGGGGTAACCGGCATCGATCCCGGCGTCCTGCG
+TCGCAGGATCATGCGCCGTGCCCACGCCGCTGGTATCGAAGTCAAACTGCTATCACTTTC
+CGCGGAAAGCATCCCGGCCGAAGACGCTAGCTTCGACACGCTGGTCAGCACCTTCACCCT
+GTGTTCCATTCCGGATGTCGAGCGCGCGCTGGCGGAAATGCGCCGCGTACTCAAACCCAC
+TGGCCGCTTGCTTTACCTCGAGCATGGCACCGCGCCCGATCCGCGTGTCCGTCGCTGGCA
+GGATCGGCTCACGCCGTGGTGGAAACCGCTGGCCGGAGGCTGCCATCTCAACCGCGATAT
+CCCGCGGCTGATCACCGGGGCCGGATTCGACATCGTAGAACAACACAGCGAGTATATACG
+TGGCCCCCGTATCCTGAGCTATGTATTTCGGGGCGAAGCACAGCCGATCGCTGTGGCAGG
+TAGTAAATAAGGTCTACCGCCGGAATCGAGGTATGACTGTAATCTACTACAGCACTGCGA
+ATGCCACTAACGCTATAAGCTTCGCCGCCGACGAACCGCAGAGCGGTTTGGCGATCAGCT
+GGAGCGTCTTGTTAGGGAGGTTCTCAAAAAATGATGATATTAGCTCCCGGTTGTCTCGAT
+ACTGTTGATAATCGGAAAGGTCCTTGAGTATGAATTTCGGCATCCTCTCGTGCCTGTGCG
+ACTTCTCAAAGATAGAAGCAGGGAAAAAGAAGTAGTCTGGATCAGATGCCTTGTTGTTGC
+TCGTTACCGCATCAAGATTCAACCTTACGAACACCACGAAATCACAATCGAAGCGTCTGA
+TCAGGAATCCTCCAGCTTCCCGTGTCCATCTACTCTTGACTTGAATCCTGGCAGAGCCGT
+ATAAATCTGTTGGAACGTTTCTAATACGCTGTTATTCTCAGCTGTTTTCCTTGTTTGGAG
+GTTGAGGCGGCCCAAAATTTTCGGATGCGGTTTCGCGTGCAGAGATCATTTCAGGGCATC
+CACAGCCAGGCGATGACGACGACGGAGATGACGCCCACGATGAGGTTCAACGGCAGGCCG
+AAGCGCACGAAATCGCTTAAGCGGTAACCGCCGGGACCATACACCATGAGGTTGGTCTGG
+TAGGCGATCGGTGTGGTGAAGCTGGCCGAGGCGGCCATGGCAATGGCGATGGCATAAGGC
+AGGAAGGGTTGGCCGAGTTTTGTGGCTGCCGCGTAGGCGAGCGGGAATACGAGTACGGCT
+GCGGCGTTGTTGCCAATGAAGGCGGTGAGGATCGTGGTGAGGGCATAGATAACGACCAGC
+ATGCCTAGCGGAGAGCCTCAAGTGGCTAGCTTCGTATTCTAAAGGCAAGGTTTCGCGCGG
+GTGGCAAAGTGTTCGCGGCCATTATCGAGTTGGTTGAAGGCAAGGAAACTGAAACCGCTT
+AAAGTGGGCGGAGAATTCCGACACATAAAAAACCGCCTTGCGGCGGTTTTTTTACTTTAA
+GTTTCAGCGTGGATTAAACGCCTTGCTTAGAATTTGAGTTTTGCGGGAGTCAGCTGGCGC
+TTTTTTCAAGCCGTTTTTCCAGGTAGATGGGCAACACGGTGAGCATGCGTAGACCCTTTT
+GCACTTCCTTGTCGCGCAGCAGATGTAACATGCCAATATAGCCACCGAGTTTGGGTTCCG
+GTTCCTGGCCCACTTTCTGCATGGCGATTGAGACACTCTTGAGGAATATCAAGAATGTAC
+CAAGACCACCCGCCGTGCTTGACTTGATGAGAACGTCAATCTGATCATCCAAGTCCGTGC
+CTTCTTCCAGGCCGGCGACAGTGTCGGCAAGATCGCCGAGTCGTGCAAGCAGACCGCTGC
+GATAGATACGCCCCAACTGAACGAGTGCTTCAGCGACAGCTTCGTCTGTGTCGTTGCGCT
+GCATGAACTCCGTCACTTCGACGGCTTTAGTGGTCAGTTCGCCCGCCAGTTTTTCTTGAA
+TGAAGGTGGTGACCAGTCGCGCCTTGCGTAGCAGTGCGAGTGCAAATTTGGCATCGGCCT
+TGAATTCATCGGCTGGCAATTCAGCGATGTGTGCAAGCCACTGGTCAAGCATTGGCGTCA
+ATGTGTTGAGGTTATCGGCAATGAACTGCGCATTGTCGCGCAGCAAGTCGAGTAGGCCGG
+CGCGATCAAGCGCGGATAGTGTGCCGACAAGTTTTTCAGCCAGCGCAGTTAGATCGTACT
+GGCCGTCGAGTGCGCCGATGCGATCAAGTGCGGCGCTGGCAGGGCCGGACAGTGGTCCAT
+CAACCAGTGCGCCAAGACGATTACCGAGGTCGCCCAAGCGGGCGAGTCCAGCCCATTGCT
+CGTCTGTGAGCGGGGTAGCGTTCCCCGATAGTGTTTTTGTTTCCATGGCATTCTCCTTGT
+CTAATCGAGAGAGTTCAGGCGTCCGGCTGCGAGTTGCACAGCCGGACGTTCCCGATGCCA
+TCAGGAGGCTATCTTTTCGGCCATCAGCTCGGAGAAGTCGAGGCCCCAGTCGGGCATTTT
+GCCCTGCGTACGGAAGAAAAGGTTCTTGTACTGCATTTTCAACAGGAATGGTGTGTGGCC
+CATTTTGAGGACCTGTGTATCGCCGCCGAACCAGCTATTGGAACGGATATAAAAGGCTTG
+GTTGTCGCCCATGTCGCCAATGCAGTAAACCACCGGTTGCAACGGTGTGTTGGCGGCGGC
+CTCGTTCATGCGGCCGACTGCACAGGCAATCTGCCGGCCGACGATATCGCATTCCTGATG
+ACCGATGGCTCCGAGCTTGGGCATGGTGACCGCAGCGGCGTCCCCGGCAGCGAAAACTTC
+CGGATATTTCGGGTTTTTCATCAACAGATCGGTGATAACGAAGCCTTCGCTGTCACTGAT
+CGGCAGACCGCGCATGAAGTCATGGGCTACCCAATCGGGGAACAGAATCTTCAGTTCAGC
+CTCAATGGTCTGACCATTGGCCAGCTCCACACCTTCGGCAGTGACGCGGGTTATGTCCTT
+GGCGTTGTTGACGTAGTTGAAGCCCATACCCGAGGCGATGTCGAGCAATTGGCCGACCAC
+CTTCTCACCAGCGTCCTCGGCGATCAGTTCGGCAGGGGTGAATACGGTGATCTTTTCGGG
+GCCGCCCTGGCCGGTTTTCTTCAGGTACGTGGCGGCGGAGAGCATGACCTCGACCGGTGG
+CCCTTCGCAGGCAGCCAGCGCATCGGGAATGCTGCCACCGGGGTAGGGTTCGAGGCCTTT
+GGCTCCGTCACCCTGGTGAAACATGGCCGAACCGACCGCGATCGGACCACCCTTGTAGCC
+GCCTTCCCACAGTTTTTTGCGCAGCTTGTTACCAAGGTAGATGTCGCTGACGCTGTCACC
+AAACTCATCGAAACCTTCGATCTTGTCAAAGGCCAGGCGATTGCCGAGCGCGACTACCAG
+ATAGTCGTAGGCGATTTTCTGTGGTGCGGCGCCGGGACGCTCGCTGGGTGTGTAGTGAAC
+TATGCGGTTGTCTACATCCAGCTCGGTCACTTCGCCCTGAACGAAGTAAATATCGTCTTT
+GACTAGCACCGGGGGGAGATCCAGGCGCTGTCCGACGGCAGGGTCTTTGTTCTCGAACAC
+GTCGGCCGGGATGTTGGGCACGAACAACAGGTAATTCTTGCGGTCAATCACGGTAATATC
+AACGGCGTCACCCGCAAATTCGCGAATTTTCTGCGCGCTTCCCAGTCCGGCGAAATTGCC
+GCCCAGTACGAGTACATGCGGTTTGGCGTTCATGTTGTTGCCTCCTTGAGATTATTGAAT
+AGCGCCCGGCGGAGCAGATCCGCGCCAGACGGATCGAATGCAGTATTTCAGATGCTTGCG
+CCAGAGCCCTTGTTCCATCATCGGTGCGAATATCTGATGATACGGGCCGTGGTCGAGATG
+CGCAAGTACACCGTTGCAGTGGATCGGATGTTTGTGACGTGCAACCCTGAGGCGGAGTGC
+GCCGGCTTTATCCAGGCAGGGCAGAATGCGTCGATTTTCTCGGAATTGACAGCTATGATC
+GGATCTCCGATCCGACATTGTTATCTCCTTGCTTCGTTGCGAATTGATGAACGAATGCGT
+TTTGGCAGATATTGGTTCAGACAACGAAAATCGGCTTTAGTTCAATACGATTGCGTATCC
+GGAGGGTTAGCCGTGTCTTTACGGACGGTCTTAAACGTTTGTCATTACAGATCCATTGTG
+GCGGATCTTCTTCTCATACGGCGTAATGTCTACTGACCGGGATCTTCGGACACTGACACA
+TCAGCAGAGTGGGGAACTCGCTGCGACAACGTCGGATCGCCTGATACCTCGGGACGACTT
+CCCGGCAAAGTACGTTGCCGCTGCACGAAAAAGCGCTGTTCCTTCTGAGCCAGGGCTGGC
+TCGCGCTTTATCCGCGCAGCCCCCGGCCACGGGCCACCTCGTGCTCTTGAAGACCCTGCC
+GCCGCGCGTTCCGAGTGGCACGTGAGCAGGTTCTGTCCTAATGCCCGACTTTCGAGCAAT
+CCGGGCACGATTGACTCCAGGCTGTACTTTTTCGCTTAGATATACACGCTTCTTTCGCCC
+GGTATCGGGCTTCTTTGCAGGGCGGCAGAATGGGGTAGCTCCCCAAAATCTACGGATGCA
+GTTTTGCGTGCAGGGATCATTTCAGGGCATCCACAGCCAGGCGATGACGACGACGGAGAT
+GACGCCCACGATGAGGTTCAACGGCAGGCCGAAGCGCACGAAATCGCTGAAGCGGTAACC
+GCCGGGACCATACACCATGAGGTTGGTCTGGTAGGCGATCGGTGTGGTGAAGCTGGCCGA
+GGCGGCCATGGCAATGGCGATGGCATAAGGCAGGAAGGGTTGGCCGAGTTTTGTGGCTGC
+CGCGTAGGCGAGCGGGAATACGAGTACGGCTGCGGCGTTGTTGCCAATGAAGGCGGTGAG
+GATCGTGGTGAGGGCATAGACAACGACCAGCATGCCTAGCGGAGAGCCTTCGGCCAGTGC
+AAGCAGCGGTTGTGCGATCAGGGCGGCTGCCCCGGTGTGGACAAGCGCTGCGGCAATACC
+GAAGGCCGCGCCGATTACAAGAATGACTTGCAGCTCGATGGCGCGTCGCGCCGCCGCGAG
+GTTGATGCAGCGGGTGACGACCATGGCGACGGCGGCAAAGATGGCGGCGGGGGCGAGTGG
+CACGATGCGGGCGGTGACAAGGCCGATGACGGCGGCGAGGATCAGCCAGGCGATCCAGGC
+GCGTTCATAGTGCGGTTGCACGCTTTCTTCGAGTGGACGCAGTAGCAGGAATTCACGGCT
+GTGCCGGTAGCGACGCTGGAATTCCGAAGGGGCCTCGATCAGTAGTGTGTCGCCAGCAAT
+CAGCGTGATGGCACCGATCTTCCCGGTCACGCGGTGGCCTGCGCGGGCGACGGCGATGAC
+GACGGCGCCATAGCGCGAACGGAAGCGGCCTTCGCGCACGGTGCGCCCGACCATGGGGTT
+TTCGGGTGCGATCACGGCTTCGATCAGCCGCCGGTCTGGGCGTGGCGTGTCGAGCTTGAA
+GATCTGGCCGGTGGTGGGAATGAGGCCACGCATCTTTTGCAGGTCGGCTACCGATTCGAC
+AATACCGGCAAAGACGAGTTGATCGTTTTCTTCCAATAGCTCTTCTGGTCCCGGGGCAGG
+AATGAGGTTGCCACCACGTTCGATCTCCACCAGGTATAAACCGGGCAGGTGACGTAGTCC
+GGCCGCTTCGAGTGTTTGTCCGGCCAGTGGGCTGCCTGCCGCCACGCGCATCTCCACGGT
+GTATTCGCGAGGATTGGTGAACTCGCCCATTGCGCCCTGGCGGTCGGGCAGCAGTCGGCG
+GCCAAAGAGCAGGATGTAGATGAAACCGGCAATAGCCACGGGTAAACCCACTGCGCCGAT
+CGTGAAAAAGCCCATACCGGGGCCGTGCGTGGTTGACGTCAGCAGGCCGTTCACGATGAT
+AGTGGTGCTGGTGCCGATCAGGGTGCAGGTGCCGCCGAGGATGGCGGCGAAAGACAGAGG
+CATCGCCAGGCGTGAGGCGGCGAAGCGGTGACGTTTTCCCCAGTCGAGCACGGCGGGCAG
+CAGGGCGGCGACGACCGGTGTGTTGTTGATGAACGCGCTGACGACAGCCGTCGGGAGCAT
+GATGCGCAACTGGGCGACCCACAGGCGGCGACTGCGTCCGAACAGCCAGCGCGCCGGGGC
+AGTGACGGCGCCGGTATGCCGGAGTCCGGCAGCCACGATGTAGAGCGCGGCAATCGCAAT
+AAGGCCGGGGTTGGAAAAGCCGCTGAATACTTTGTCGATGGGCGCGCAGCCGGTGACGGC
+CAGGATGGCGAGTCCACCGACAAGTGGCAGGTCCGGGGGCATGCGCGGCCAGGCCAGACC
+GAGTACCACGGCACCCAGCACGACCAGGGTCAGGATGGCTTCCCAGCTCACGTGGTCGTT
+TCCTTTTGCAGTTTGTGGGGTTTGAGCAGAGGCATGAGGTAGTGGCCGGTGTGGGAGTGC
+TCCAGCCGGGCGATGTCCTCGGGGCTGCCTTCGCCGATGATTTGGCCTCCGCCGTGACCA
+CCTTCGGGGCCGAGATCAATGATCCAGTCGGCGGTCTTGATGACGTCCAGGTTGTGCTCA
+ATCACGATCACGGTGTTGCCATGGGACCGAAGACGCAGCAGAACGGCGAGAAGTTGGCGG
+ATGTCATGGAAGTGCAGGCCGGTCGTGGGTTCGTCGAGGATATAGAGTACACGCCCCGTG
+TCGCGTCGACTCAGTTCCCGGGCGAGTTTGATACGCTGAGCTTCGCCGCCCGAAAGGGTG
+GTGGCGCTTTGGCCCAGTTTGACGTATCCGAGTCCGACCGTGACCAATGTGTCCAGGCGA
+TGATGGATGCTGGGGATGTTGGCGAAGAATTCCCTGGCTTGCTCGGTGGTCATGTTTAGA
+ACTTCTTCGATTGTGCGGCCTTTGTAATGGATTTGTAGCGTTTCCCGGTTGTAACGGGAG
+CCGTGGCACAAGTCGCAGGGCACGTAGATGTCGGGTAGGAAATGCATTTCCACTTTGACC
+AGACCGTCGCCCTGACAGGCTTCGCAGCGGCCTCCACGAACGTTGAACGAGAAACGGCCG
+GGTTTGTAACCGCGTGCCCGGGCTTCGGGCGTTTGTGCAAACAGTTCGCGAATGGCGGTG
+AACACGCCAGTGTAGGTGGCTGGATTCGAGCGTGGCGTTCGACCAATGGGGCTTTGGTCG
+ATGGCGATGACCTTGTCGAGCGCGTCCAACCCTTCGATGGATGCATGGGGCGCCGGTTCG
+GTGCGCGCGCGGTTGAGCAGCCGCTCGCCGGCGGCCTGCAGAGTGTCGAGTACCAATGTG
+GATTTACCCGAACCGGAGACGCCGGTCACGCAGGTGAACAGGCCGAGCGGAATGCTGACC
+TCGATGTGCTTGAGGTTGTTGCCATGCGCATCGCGGATGATGATGGCTTGACCCGGTTGG
+GGATGGCGGCGAGCCTGCGGTACAGGGATCGTGCGGCGACCGGACAGATAGTCGGCGGTC
+AGCGAATTCGGGTTGTTCATGACTTCTTCAGGCGTGCCGGTTGCTACCACTTCGCCGCCA
+TGAGCACCAGCGCCAGGTCCCATGTCGATCAGATAATCGGCGCTGCGGATCGCATCCTCG
+TCGTGTTCGACCACGATTACGCTGTTGTCGAGGTCGCGTAACCGCGTCAGGGTATCGATC
+AGACGCCGGTTATCGCGCTGGTGCAACCCAATGGAGGGTTCGTCCAGTACGTACATCACG
+CCGGTCAGGCCTGAACCGATCTGGCTTGCCAAGCGGATGCGTTGAGCTTCACCGCCGGAC
+AGGGTTTCGGTACTGCGGGCGAGAGTCAGGTAGCCCAGTCCGACATCCACCAGAAAGCCC
+AGGCGTGAATGCAGTTCGTGCTGGATGCGTTTGGCAATTTCGCCGCGTCGTCCGGGCAGA
+TCGAGGTCGTTGAAGAAACGCCAGACCGCATCTATGGCCAGGTTGCTGATATCCGGCAGC
+GTGGTATCCGCAATGAAAACATTGCGGGCAATTTCGCCGAGTCGCGTACCATTGCAGGCA
+GTGCAGGCGCGGCTTGACTGGTAGCGCACCAGTTCATCGCGCACGGCCTGTGAGCCGGTT
+TCGTGGTAGCGGCGTTCAAGAATATTGAGTACCCCTTCGAAGGTGTGACGGCGTTGTTGT
+TTTTGTCCGCGTGCCGATACATAGGTGAAGTCGATTTCTTCTTCGCCGCTACCGTAAAGC
+AGTACGCGGTGTGTGCGTTCAGACAGTTCGGACCACGGCGCTTCGGTGTCGAATTCGTAA
+TGCCGGGCCAGACTTTCGATCAAGCGGTAATAATAGGGGTTGCGGCGGTCCCAGCCGCGG
+ATGGCGCCGCCTGCCAGCGAGAGCGAAGGCTGGGTGATGATGCGCCCCGGGTCGAAATAA
+CTTTCTCGCCCCAAACCGGCGCATTGCGGGCAGGCACCGGCAGGGTTGTTGAATGAGAAT
+AATCGTGGTTCCAGTTCCGGGATGCTCCAGCCGCACTGTGGGCAGGCATGGCGGGCAGAG
+AAGACCATTTCGGACGTGTGGGGCTTGTCGATATCAGCGATCAGTGCACTGCCGTCCGCA
+AGCGCCAGTGCCGTTTCGAAAGATTCGGCGAGCCGGGCCGCCATGTCGGAGCGGATGCGG
+AAACGGTCAACCACAATTTCGATGTCGTGGGGCTGGTGCCCATCGAGCCGGGGCAGCGGG
+TCAAGTTCGTAGACGGTGCCGTCAATACGCGCCCGGATGAAGCCGCGGGATTTGAGATCT
+TCCAGTAGTTCCTGATATTGCCCTTTGCGACCGTGCACCACGGGGGCAAGCAACATGACC
+CGGCGTTCGGATGGATCGGCGAGCACCGTGTCCACCATTTGTGAAACGGTTTGCGCATCC
+AGGGTGAGACCGTGATGTGGGCAGCGGGGCGTGCCCGCGCGCGCAAAGAGCAGGCGCAGG
+TGGTCGTGAATCTCGGTGACCGTGCCGATAGTTGAACGCGGATTGTGTGAACTGGCTTTC
+TGCTCGATGGCAATGGCGGGTGACAACCCTTCTATCGAGTCCACATCCGGCTTTTCCATG
+AGCGCCAGGAATTGACGTGCATATGCGGAAAGAGATTCGACATAACGGCGCTGTCCTTCG
+GCGTACAAAGTGTCGAAAGCCAGCGAACTTTTACCCGATCCGGACAAGCCTGTAATCACG
+GTAAGACTGCCTCGCGGAAGCTCTACATTGATGTTTTTCAGATTGTGTGTGCGGGCGCCG
+CGTATGCGGATTGTGTCCATCAGGCAGCGTTGCTCAGGCAAATGTTTTACTATACGGCGG
+CGTGCAGGGCTTTGCAAAACACCGATCAGCCCTGTAGCTCAAAGCCAAAAAGGAGAGTAA
+GCATGGCTGGATCAGGCAAGCTTAGAAAGGATGCGGGCATTATCGGTCTGCTGTATTTTA
+GCCTGGGTGGCATCATCGGTTCGGGATGGCTTTTCGGTCCCTTCGATGCAGCCAAGGCCG
+CGGGTCCCTGGAGTATCGCCTCCTGGATTATTGGTGCCGCCGTGGTGATGTTGCTGGCAC
+TGGTGTTCGCGGAACTGGCGACAATGATGCCCAAGAGCGGGGCATTGATTCATATCAGTC
+ATATCGGGCATGGCGAATTGATAGGGCGCATCTGGTCCTGGATTCTGTTTTTATCCAGTG
+TGGTGACACCGCCGATCGAAGTTATGGCCGTATTGACTTACCTTAACAACAAGATTCCCT
+ATTTTGTCGATCCCTCGACCCATGTGCTCTCTACGATAGGTTTTTTCGCAGCCATCGTAT
+TGTTGGGTGTGGTGGTGGTCGTGAACTTCTTCGCGATCCGTTTCGTATTGTGGATCAACA
+ATATCGCGACCTGGTGGAAAATGTTCATTCCGGCAATTAGCATTATAGTGCTGATGAGCT
+ATTCCTTCCATCCGGGCAATTTCCATCTTGATCTGGGCTCGGTAAATGCCGCAGGGATGC
+TTACGGCCGTGTCCACTGCGGGTATCGTTTTCAGCTTTCTGGGTTTTCGCCTCGCCATCA
+ATCTGGGCGGAGAAACGAAGAATCCGGGCAAATACATTCCGATCGCTGTCATCGGTTCGG
+TGCTGATTGCGACCCTGATCTACGTGGGCCTGGAGGTGACGACCATCACCTCAGTGCGCC
+CTTCGGATTTCGCCAATGGATGGCCGTCGCTGGCTTTCAAGGGTGACGCCGGTCCCTTCG
+CAGCTCTCGCCGTGACCATCGGCGCGGTGTGGTGGTCCTGGGTTCTATACGCTGATGCCA
+TCGTTTCACCGTTTGGCACGGGACTCATTTATACCACCAATACCTCTCGGCTGGGTTACG
+CCATGGCCGAGGTGGGCAGTGCGCCGAAGAAGATGCAGAAGCTGAGTCGTCAAGGGGTAC
+CGTGGATTTCGTTGCTGGTGACCTATGTGATTGCCTGCATATTCTTTTTCCCGTTCCCGT
+CCTGGCACCAGTTGGTTGGCTATGTCTCCGACATCACGGTGTTGTCATACGGCATTGGTC
+CGGTGGTGCTGTTGATCATGCGCAAGCGCCGCCCGGAGGAGCCTCGTCCGTTCCGGCTCA
+AGGGTGCCAAGGTTATTGCGCCGATGGCATTTATTGCTTCCAACTGGGTGATTTTCTGGA
+CTGGCTGCACGACGGTGACCTTTCTGTTCGGGTTACTGGGTTCGCTGTTCGCGGTTTATG
+CAATCTGGTATTACATCATTGCCCGAAAGCCGTCAAAAGAGTTTGGTTGGAAGTATGCCT
+GGTGGGTGTTTCCCTATTTCATCGGGATGTGGTTGTTGTCTTATATCGGACCTTCCACTT
+TGGGACCGGCGCATGTCAGTCTGTTCAATGTCCAACCGCTTGACATCTTGCCGCTGGGCT
+GGGACATGATTGCCGTGGCGGTATTCAGTCTGGCTGTGCTCTATACTGCCACGTCCAGTG
+CTTTGCCACGCGAAGAGGCGGACCGGTACTTCGATGAGCTTAAAAAGCTTAATTTGCCGG
+AAGAGTACTCCGAAGGCACGGAATCGCCTTGATTCTGCGTGTGTCCGGGCGTGTGGCCGA
+TAGCTTTGGCCACACGCCCGGAGTGTATCTGTGGGTCTGGGAAGCCCGGTATGAAAGCGA
+TGTACGACTTTTCAGTGAATAATCATAAGCATTTTTAGCAGCGTGATACCCCCGAACAGA
+TGGTTTTGAGCTACAGTTGGAGTTCGGGCGACCGCACACTCTGATTCTGACCTGAGCGTG
+CCAAGGGGGAGCGGTGCAAGCAACCGATTGGTTACACCAGATCGCGGGGCCGGCGCTGGT
+GCTGAACTTTGCCGATGGTACGGTTATTGATATCAATGCCGCAGGCCGACGGCTTGTGGG
+CATTGAAGGCCAGGGATTGATTGGGCAGGATTTTTGTGGGTTTTTTGTGAGCAGCGACGC
+AGATTGTTGCTGGCCAACTTTACAACGCTCCATCAATCTTCAGGGCGGCTTCCGTTACGA
+AGGATTGCATTTGCGTACGCCGGGCGGCGCCATGCGACGGGTCAATGTCAGCGCGGAATT
+GCTGCAATCCGAACAAGAACGCGCTGTCCTCATGTTGTTGCAACCGGGCACTGCGTCATC
+GCCCCAGGCTACTGATCACGAAAAAGAGTTGGCTCAGTATGCAACCGTGGGGCTTTATCG
+TCTGGATGCGGAAGGGCGACTCACCCACGCGAATCATGCATTGGCCCGGTTGCTGGGCTA
+CGAGACGGTGGGTCAGTTGCTTGATTCCGCAGCGGTTCAACGCAGCCAGTGGTACGTCTG
+CGATGGGGTTTCCGAGGAGCGGGTCAGCGATGTGAACGACGCTGCAATTTACCGATGTAA
+AGTGCAACTGCGGCGTGCCCATGGAGCAGCGTTTCGGGCGGTTGAGGCGATACGTGAAAT
+ACGTGATGTCCGGGGGCAGTTGATGAGTCGGATTGGCACGCTGCGGGAGATTTCCGATCA
+ATCGTCTTCCGAACAGGCACTTGCCATTTCGGAAGATAAATATCGCAGTCTGGTCGAGCA
+CAGCCAGGACGGAGTTTTTGTTATTCGCGACGGCGTCTATGTCTTCGTCAGCCAGGTTTA
+TTCGTCCATGCTGGATTATGCGCCGGAAGAAATGGTGGGCGAGTCATTCCTGCGTTTTTT
+TGCACCGGAAGACCGCCAGAAGATTGTCGATGTCTGGCATGAACGTCAGGCGGGGCACTG
+GGAGCAGGGAGCCTACGAGGCGCATCTGCTCAAGAAGGATGGTACACGGGTGCTGGTATC
+CGTGCGGGCAGGCCCGATTCGTTTTGCAGGTGCGATGGCCAGTACCGGTACCGTGCGTGA
+CATTACCGCATACCGCGATACTCAGCAACAGTTGAGCATGGCCGAGCAGCGCTACCGCGA
+CATATTCGAACACGCGGTGATTGGGATTTATCAAACCGCGCCCGATGGCAGGTTGTTGGC
+GGCCAATCCGGCGATGGCACAGATTCTGGGTTACGACTCTGTCGAGGAACTGCAGGAGCA
+GGTGGATGATGTCGGAGAACTGTTTTTTGATCGGATTGAGCGCGATACGCTGATTGAAAA
+ACTTGAAGCCGAGGGCCGCATGTATGGGGCCGAATTGCGGCTACGTCATCGCAAGGGGAC
+GCAACTATGGGTTCAGGACAGTGCGCGCGTTGTATACGACGCAAACGGCAAGCTGGTTTG
+CTATGAAGGTATGGTTGCCGACATTACGGCACGGAAAATCGTCGAGCAGGCGCTGCACCG
+TTCGGAACAATTGTTCCGGACACTGGTGGAGCACACACATGTCGGCGTGATCATGGTGCG
+CGAGGGCGTCGTGACTTACGCCAATCGCGCGCTGGCTCACATGCTGGATTATGCGGAGTC
+CGATTTGTTGGAACAACCGCTGGCGTCTTTGTTCGCCCCGGAGTCCCGCGACTGCGTAGA
+ACGGCTGGAGCAGGAGCTGAAGACAGCCGTCGGATCCAATATTTACGAATCCTCGATGTT
+GGCAGCCGATGGAACGCGACGGGTGCGAGCCAACCTGAGCGTAGCGTCGGTCATCTTTGA
+AGATAATCCGGTGATGATCATCACGGCGCATGATTTGACCCGTGAAAAACGGGCCGAAGC
+CCGTTTGCGGCGTCTGGCTACCCACGATCCATTGACGAATCTGCCCAATCGCGTGGTGCT
+GCGGGAACGGTTGGCTCAAGTGCTGAAAAAAACGCGTGAGACCGGTAATGTCGATTGGGC
+GGTGCTATTTCTCGACCTGGATGCCTTCAAACTGGTGAATGACAGCCTGGGACACGCCGC
+CGGCGACGAGTTGCTGAGGCAGGTGGCCGTGCGTCTGCGTCGGGCTGTGCGTCACGACGA
+TCTGGTCTGCCACCACGGCGGCGATGAATTCGTGGTGCTGGCCTTCAACATTACGCACGA
+AATCGATGCAGTGGAACTGGCTGAGCACATTGAAACTGCAATGGCCGAACCGTTCCGGAT
+CAGTGACCATGAAATTTACAATCAGATCACGATCGGTATTGCTCTGGGGCGACAGGAATA
+TGAATTGCCCGAAGAGGTGCTGCGCGATGCCGATTCCGCTGTTGCTGCGGGTAAGCGCCT
+GGGAAAAGTCTGCCATGTGGTGTTCAGTTCCAGCATGCATGTTGCGGCGATGGAGCGTCT
+GGAGCTGGAAACCACATTGCGTGCTGGCCTGACGCGAGGCGAGTTCGATTGCTACTACCA
+ACCCATCTTCAACGTCAAAAACAATCGCATCGAGAGTTTAGAGGCTTTGCTGCGGTGGCA
+TCATCCGGAACAGGGCGTGTTGCGACCGCACTCATTCTTGCAGGTGGCAGAGGAAAGCGG
+TGCCATCGTGCCGCTGGGTTGGATCGGTTTGCGGCGCGCGCTTGCGGCGTGCAGTCAATG
+GCAAAGCCTGGGCTTGGAAAGAGAGGTCAGCGTCGCGGTCAATTTGTCCGATGCCCAGTT
+TCGCTTGCCGCAACTGCCGGAGCAGTTGGCTCATGAGCTGGAACAGGCTCAATTGCCGTT
+CCATCTGTTGCATCTGGAAGTAACCGAGCGGGTGTTTCTGGAAACGCCGGGTCTGGCACG
+GCGTACATTGGGTCGATTGCATGCTTTGGGGGTCAAGTTATACCTGGACGATTTTGGCAC
+CGGTTATTCGGCGTTGTCCTACCTGCGTGAACTGCCGTTTGATGCCTTGAAGGATAGATC
+GTAGCTTCATTGCCGATTTGCCCCGGGATGCGCGTACGGTCGCCATCGTGAGAAATATCA
+TTTCATTGGCCAATGACCTGGAGCTCTTGGTCGTTGCCGAAGGGGTGGAAAAGCCCGAAC
+AGGCGCGCATACTCGCTGATATGGGGTGCTATCGTTTTCAGGGGTATTACTACGGTGAGC
+CCATGGATGGCGAGACCAGTTGCAAACACCTCGATAACCGGAGGAGGCAACAAGTCGCTC
+AGCATGCCGTTGATTGAGCCGGCTGCCAGCGGATTCGGCCTCCCCGGTTGCCGCAACGGG
+AGCAGTCGGCGACAATATACGTCCTACTTCAGGAATCAGTCCCATGCCAACACGCCGCGA
+ACTCGCCAATGCCATTCGGGCATTGGCCATGGATGCCGTACAAAAAGCCAATTCTGGACA
+TCCGGGCATGCCGATGGGGATGGCCGATATAGCCGAAGTCCTGTACAACGATTTTCTGCG
+CCATAATCCAGCCAACCCGCACTGGCCGGGGCGTGATCGGTTCCTGCTCTCCAACGGCCA
+TGGCTGCATGTTGCAGTACGCAGCGCTGCATCTGTCGGGTTACGACCTGTCGATGGATGA
+GATCCGCAATTTTCGCCAGTTGCACTCGAAAACCCCGGGTCATCCCGAATACGGTCATAC
+GCCCGGCGTCGAAGTTACCACTGGCCCGCTCGGACAGGGCGTCGCCAACGGTGTGGGCCT
+GGCGTTGGCCGAGGCGTTGCTCGCCGCACAGTTTAATCGCCCAGGGCACAAAGTCATTGA
+CCATCACACGTATGTGTTCTGCGGCGACGGCTGTCTGATGGAAGGCATTTCCCACGAAGC
+GGCCTCCATCGCCGGTACGCTGGGTCTCGGCAAGCTCGTGATGGTCTATGACGACAACGG
+CATTTCCATCGATGGCGAGGTCAAGGGTTGGTTCCATGACGACACGCAAAAGCGCTTCGA
+GGCATACGGCTGGCATACGATCGGGCCGATCGACGGTCACGATGCCGAGGCTCTCAAAAA
+AGCCTTCGCCGAGGCTCAGATCGAAACGAAGCGACCGAGCCTGATTCTGGCGCGCACCAT
+CATCGGTTTTGGCGCGCCCGACAAGCAGGGCACGGCAGAAGCGCACGGTAGTGCGCTCGG
+CGATGCAGAAGTGGCCAAGGCCCGCAAGGAGTTGGGATGGAAATTCCCACCGTTCGAAAT
+TCCCGAAAGCATTTACGCCGGCTGGGATGCGCGCGCTCGTGGCGAGCAGGCCGAAACCGA
+ATGGCACGAACGCTTTGCCGCTTACGCCAAGGCGCACCCTCAATTGGCAAAAGAATTGAA
+GCGTCGGCTGGCAGGTGAATTGCCGGCGGATTGGGCCACGACGGTAGAGCAGCATATCGC
+GCATGTCGCCAGGAATGGCAAGGCACAGGCGACGCGCAAAGCCTCGGGCGCTACACTTGC
+GGCGCTGGCGCCGACGTTGCCGGAAATTGTCGGCGGATCGGCGGATTTAACGCCGTCCAA
+CGACACTTGCTGGCCGGAAGCGAAAGCCGTCAAGCCCGGCACGCCGGAAGGCAATTATCT
+GCATTGGGGTGTGCGCGAATTCGCGATGACCGCGATTCTCAATGGCATGGCTGTCCATGG
+CGGGTTTGTTCCTTATGGCGGTACGTTTCTGACTTTTTCCGATTACGCACGCAATGCAGT
+GCGTTTAGCGGCCTTGGCGCATTACCCGACCATCCTTGTTTATACCCACGACTCGATCGG
+TCTGGGCGAAGACGGCCCTACACATCAACCCGTGGAGCATGTGGCGAGCCTGCGGGCCAT
+GCCGAACCTGACTTTGTGGCGCCCGGCTGACGACGTGGAAACCGCCGTTGCGTGGCGCGA
+TGCGATCGAACGTCGCGACGGGCCGACCATGCTTGTGCTGACTCGCCAGTCGGTGCCGCA
+TTACGAGCGCAAGGCACAGCAGATCGAGGCCATACATCGAGGTGGCTACATCCTGCACGA
+ACCCCAGAACGCCCCGCGGGCGCTGATTATCGCGACCGGTTCCGAGGTGGATCTGGCGAT
+GCAGGCTGCGAGGGTATTGACCGAAGAAAATCTGCCGGTGCGGGTCGTGTCGATGCCCTG
+CCAGGAATTGTTCCTGGCACAGGATGTCGATTGGCAGGAACACGTATTGCCGGCACAGGT
+GACGGCTCGTGTAGCGGTTGAAGCAGGGGTGTCCATGCCTTGGTATCGTTTCGTCGGCAT
+CCATGGCCGGGTTGTCGCGATGGAGCGCTTTGGGGAATCGGCCCCGGCCAAACAGTTGTT
+TGAGGAATTCAGTTTTACGGCAGAGCGTGTTGCGGCCGCAGTGCGTGAAGCGGTGGCCGC
+TGCAGCCGGTTAACGGTGAGGTTGCGGGCAGAATGCCCGGTCTGTTTTGGTAATGGTTTC
+TGAGGAGCAGAAAATGATCAAGGTGGGTATCAACGGCTATGGCCGAATTGGACGCAACGT
+TATGCGCGCGTTATACGAAAGTGGACGTCGTGATCAGTTGCAGGTAGTTGCGATCAATGA
+TTTGGGCGATGCACAAACGAATGCCCATTTGACCCGTTACGACTCGGTCCATGGCCGTTT
+CCCGGGTGATGTACAGGTTGAACAGGGTCATCTTGTTCTCAATGGCGATGTGATTCAGGT
+ATTGGCCGAACGCGACCCGTCCAAATTGCCTTGGGGGAAGCTGGGCGTGGATCTGGTGCT
+GGAATGCACTGGTCTGTTTACTTCGCGCGAGAAAGCCAGTCTTCATTTGCAGGGCGGCGC
+GAAAAAGGTGCTGTTGTCTGCGCCAGCCAAGGATGATGTGGATGCCACCATTGTTTATGG
+TGTGAACCATAAGACGCTTGAACCTGAAAAGCACGTGATCGTTTCCAATGCGTCCTGCAC
+CACCAACTGCCTGGCACCAATCGCGCAGGTCATGCATGAGCTGGCCGGTATCGAGGGCGG
+TATCATGAATACGGTGCATGCATTCACCAACGATCAGAATTTGTTGGATGTCTATCACAA
+GGATCTGCGTCGTGCGCGTGCCGCCACGGCGAGCATGATTCCGACATCGACCGGTGCTGC
+CAAGGCGATCGGATTGGTGCTGCCCGAACTCGACGGCAAACTCGACGGCTTTGCCATTCG
+AGTGCCGACCCAGAACGTGTCCTTTGTGGATCTGACACTCAACCTGACTCGTGAAGTGAA
+GGTCGAAGATATCAACCGCGCCATGCGCGAAGCGGCGGATGGACGGTTAAAAGGCGTACT
+GGCTTACAACGAGGTTCCGCTGGTTTCAATTGACTTCAACCACAATTCGCATTCGTCGAC
+TTATGATGCCGGTTTTACCAAGGTCAAAGGCCGACTGGTGAAAGTCTGTTCGTGGTACGA
+CAATGAGTGGGGCTTCTCCAACCGCATGCTCGACACGGCCGCGGTCATGTTTGGTCGCGG
+CTGACGCATGGGAGTCAAATCACTCAAGGATTGCGAGCTGCAAAACCGGCGTGTGTTGAT
+GCGGGTGGACTTCAATGTGCCCGTCAACGACGGAGCCATTGCGGATGACACACGTATTCG
+GGCCGCGCTGCCCAGTATTCACGAGGCATTGAAGGCTGGGGCGCGCCTGATGCTCATGTC
+ACATTTTGGTCGTCCTGAAGAAGGCAAACCGGAATCGCGCTTTTCGTTACATCCGGTCGC
+CCGGCGTCTGGGTGAGTTGCTGGGATTCGATGTGCCACTGGTGACCGATTATCTGGCGCG
+GGACCCGGAACCCGGATCGGGACGTGCCGTACTGTTGGAAAATGTCCGTTTCAATGTCGG
+CGAAAAACGCAATGAAGAAACACTCGCCCGACGCTATGCGAACTTGTGCGATGTCTTCGT
+GATGGATGCCTTTGGCAGCGCGCATCGTGCCCAGGCTTCCACGTATGGTGTGGCGCGATT
+TGCGCCACAGGCCGTCGCGGGGGAGCTGCTCTGCGCCGAGCTCAAGGCACTGGGTCGTGC
+GCTAAAGGCGCCCGATCGACCACTGATAGCTATCGTTGGCGGCTCCAAGGTTTCAGACAA
+AATAGGGGTGCTCGATGCATTGATCGAGCGATGTGATGGGCTTGTCGTTGGCGGTGGTAT
+TGCCAATACTTTTCTGGCTGCGGCAGGGCATCCCGTGGGCAGATCGCTTTACGAACCCGG
+TTTTGTGGACGAAGCGAAACGTCTGATGATAGCGGCCCGTGAACGAGGGGTGAATTTCCC
+GTTGCCGGTCGATGCCGTGGTGGCTGAAGCCCTGGCCGAAGATGCCGAGGCCGACGTCAA
+GCCGGTGCATGCGGTGGGTGCAGGCGATATGGTTCTCGATATCGGCCCGGAAACCGCCGT
+GCTGTATCGTCCTTTGCTGGCGAATGCGGCCACCATCGTGTGGAATGGTCCGGTGGGGGT
+GTTCGAAATTGACCAGTTTGCCGAGGGTACCCGCGCGGTGGCCGAAGCGGTGGCTTCCAG
+TGGGGCTTTTTCGATTATTGGCGGTGGCGACACCATCGCGGCGCTGGCCAAGTTCGGCGT
+GACCGACCGGGTGAGTTATATTTCCACCGGTGGCGGGGCGTTCCTGGAATTTCTCGAAGG
+CAAGACCCTGCCCGCCGTGGACATTCTGGAGGCGCGTGCGAGTGACTGAGACAATGGCGC
+GGTTTCGGCGTACCAAGATCGTTGCCACGCTCGGACCGGCGGTGGATGAAGGGGACGTGC
+TGGCCCGTATGATTGCTGCTGGTGTGGACGTTGTGCGCCTCAACCTTTCGCACGGCACGC
+ACGCCGAGCATCGTAAGCGCGTCAAAGCGGTTCGCAAGGCTGCGGCCGAGCAAGGCCGTG
+ACGTGGGTGTGTTGATCGACCTGCAGGGACCCAAGATCCGGATCGAATGTTTCCGTGATG
+GGCCGATCGAGCTGAAGGAAGATGATGCCTTCACGCTGGATTGTGGCCTGGGTAGTAACG
+CAGGCGACAGCAAACGAGTGGGTGTCGCCTACAAGAATCTGCCCCGCGACGTGCAGGCTG
+GCGACATGCTGGTGCTGGCCGATGGGGAAATTGTTCTTGAGGTCCGTGAAGTGATCGGCG
+AGCAGGTGCATTGCCGGGTCGAGACGGGTGGTGCCCTGTCGGATCACAAGGGGCTGAATC
+GCAGAGGTGGAGGACTCAGTGCCGAAGCGCTGACGCAGAAAGATCAGGTGGATATCCAAC
+TTGCGGCCGAGTTGGAAGCGGATTTTCTGGCGATCTCGTTTCCCCGTGTTGCTGCGGATG
+TGGAACGGGCCCGCGCTTTGCTGCGTGCGGCGGGTGGGACGGCGGCCATCGTGGCCAAAA
+TTGAACGTGCCGAGGCGGTCGAGAATCTGGATGAGATCATCGATGCCAGTGAGGTCGTGA
+TGATTGCCCGCGGTGATTTGGCCGTCGAGATTGGCGATGCACCGCTGCCGGGGGTGCAAA
+AGCGCATTGTTCGCCATGCTCGCGCACGCAACACGGTCGTGATTACTGCAACTCAGATGA
+TGGAATCGATGGTGACCAGCCCGACGCCGACCCGCGCCGAGGTACTGGATGTTGCCAATG
+CGGTGCTCGACGGTACCGATGCGGTGATGCTCTCGGAAGAAACCGCTGTGGGCAGGCATC
+CGGTCAAGGTTGTCGAGGCCATGGCCCGGGTGTGCCTGGGGGCCGAAGCCGAACCACGTG
+AAGACCGTGATCGACGAATTGGGGGTGATCGTTTCGAGCTTGTGGACGAGGCCATTTCCA
+TGGCGGCCATGTCTGTCTCGCAGCATACCGATGTGACGGCTCTGGTTGCTTTAACGGAAT
+CGGGCCGTACACCGCTGTATATGTCACGGGTACGTTCGGGCATACCGATCTACGCCCTGA
+CGCGTCACGAATGCACCCGCCGTCTTTTAACCTTGTATCGCGGCGTGTATCCCATTGCTT
+TCGAAGACGAGCATGAATCCGACGAAGTCTTGCCGGATGTGGCGGCGGCGTTACTGGAGC
+GTGGTTTGGTCACACCACACGCGCTTATCATTGTTACCCGGGGCAAGCTACGGCATGTCT
+CGGGTGGCACCAACAGCTTGCATCTGGTGCAGGTAGCTGATGTCCTGCCTGAGCAGGTTT
+TATAATGAACGGTCATTGGGCCAGGGAAAAGAGGCGCATGCGAGTAATAAACAGGCTTTT
+GGGACTTTCCGCAGTGGTGATGGTGCTGGTCTTGGTCAGTCCCACCGCATCAGCCAGTAT
+TGCGAGCGATGCGGTGGCGTACCCACCGGTTTCGTTAAGCAATGTGCCTCCGGCCAAGGC
+CGAGGAGATTCGCAAGGGTGAATACCTCACCAAATTATCCGATTGCATGGCCTGTCATAC
+TGACCACGGTAATGGCAAAGCAGGGAAACCGTTCTCAGGCGGCTTGGCTATCAAGACGCC
+TTTCGGCAATATCTACAGCCCGAATATTACCCCCGACAAGAAAACCGGCATCGGCAACTG
+GACGTTCAAGCAGTTTGACGATGCGGTGCGTTATGGCGAGGGTCCGAATGGTTATCTGTT
+CGCCGCCATGCCGTACAACTACTACAGCATGATGAACAAGGATCAGGTCCATGCCATCTG
+GGAATATCTCAAGCATGTGCCGGCTGTAAACCGTAGAAACAAGCCACTTGGCATGCCGCC
+GCCATTCCGCTGGCGTTGGCTGCAATTCGGCTGGCGATTCATGTTCGTCAAGCCCACACA
+AGGTGAATTCAAATACGATCCCAAGCATTCCAAGGCATGGAATCGCGGACGTTTTATCGT
+TGAAGGCCCGGAACATTGCGGTGCTTGCCATACGCCGCATAACATGCTGGGCGGTTCCGA
+GAAACGTTTTTTTCTGGGTGGTTCGGATATCACCGGGTTCTGGGCTCCGAATATCAGCGG
+TCTGGCGACCAAGCCGCACCCCATCGCAACCATCATGCGGGTCTTTCGTGAAGGCAAAGG
+CCTGGGAGGGGGCGACCTGAAGGGGCCGATGATTGATGCCATAGCCAACAGCATGCGGTA
+TATGACTCCTGCGGACATGCGAGCTGTGGCGGTTTATATCCAGAGCGTGCAGAGTGAAGT
+GCCGCCGGGACCGCGGCCAGTGGCCATGGATGAGGTGAACCTTGCCCGGGGTGAAAAAAC
+TTATCAGACCGATTGTGCGGCCTGTCACGCAACGGGCATTGGAGGGGCGCCGCGTGTGGG
+TGTGGCCAAAGACTGGGATGCGCTTGGCAAAAGCCCGTTGTTCATATTGTTCGAAAACGT
+GTGGCATGGCGTGAGCATCATGCCGCCCAAGGGCGGTTGCAAAGCATGTACACGAGACGA
+TGTCACATCGGCCATCGTGTACATGCTCAAGCGGAGCACCTCCCGGTCAAGCAAACCGGC
+AGTGCAGGCCACGACTTCGAAAAGCGGCATTCCACGGGATACGGTCAGCCTGGCGGTTGG
+CGACAAGATTTATCACGCACACTGTGCCGCTTGCCATGCCAGCGGAGCTGCTGGGGCACC
+GCGTCATGGGGACATAAAGGAGTGGGCAAGTCGGCTCAAACTGGGGCTGGACAAGTTGCA
+CCACAATGCACTCGATGGCATCGGCATGATGCCGCCCAAGGGTGGATGCACCAGCTGTAG
+CAAGGATCAAATCCTCTCTGCGGTTGATTATCTGGTCGACGGCAGCGGTGGCAAGGCGCT
+GGTGGAGAAATCGCTCAGCGGCAAGCAGGGAGGTTGAGATGAGCGGGGATAGCATACTCA
+GGATTTTCTGGTGGTTGGTGCTCGGTGCCTGGATGTCCGGCATCGGTGTGATGCTGGGCC
+GTGAATTGGGCTTGACCGTTTTACTGCGATACCTGGGGCGTAACGAATCCGAACGCCGCG
+AATTGCTGGCACCACATATCGAACGTCCCAGCGAGGGGCATCAGGTGTGGCTGCTGCTCG
+GCGGAGGCGCTCTGATGGCGGCCTGGTGGCCCCTGTTTACTGCAACGCTGTTTGGTGGAC
+TCTGGCTGGTACTGCTCTTCATGGTACTGGCCGTGCTGGTGGGCCCTGTTGGGCATGGTT
+ACCGGAAACGCCTGAGCGAGCATACACGTGGGCCATGGGACCTTTTGTGGGCAGGGATTT
+CTCTGGCGGCATTGCTGGTGTTTGGGCTTGCCATTGGTGCGACTGTCAGTGGTGTGCCGC
+TGCACTTTGACGCACACATGGATGCGATGTGGGGCGGGTTCTTTTCCCGTTTTACGCCCT
+ATAGCCTGTTGGTACCGGGACTGATGGCCATCACTTTCGGCTTGTGGCTTGCTGCGGCAC
+GCGCGGCGCATGAATGTACGGGAGCCGTGGCTGCTCGGGCACGCGCGCTGTTGTTGCCGG
+TGGGGGGGGTGACATTGCTGATTTTTGCCGGTGGCGCGGCTTGGGCCACGCAGTTGCCGG
+GTTATGCCGTAGGCGGTTTGCCGAAAGTCGGAGCGAGTCCGCTTGATGGCACCACCTTCG
+CAGTGGGGGGGGCCTATCTCGAACGTTTCCTGTCGCATCTGCCGTTGGTGATTGTGCCGG
+TATTGACCGCGCTGGCCATAGTGGGTGCCCTGTTTTTCAGTTGGCGAGGGCGACTGCAAC
+GAGTGGGGCCATTGGTTGTCATCGCTGTAGTTGGCATGGTCGCGACACTGGGTGCCATGA
+CCTACCCCGTGATTCTGCCTTCGTTCGCTGAACCGGCCCAAAGTTTGACGCTCTGGAATG
+CAGCGGCCGAGCGTCCTGTGCTGGTGGCTTTCCTGGTGTGGTTGGGTATCTTGGTTCCTG
+TCGTCCTGGGTTACGAACTCTGGCTTCGTCGCCGGAATGCACAGACGGTAGTGGCCGGGA
+GTACGGCGCGCTGAATCAAGTGCGGCCATGAACGCGACCGCGCCATTGCAGGAGCAGGAG
+CCAGAGCCGGGTAACCGGCGCTTTCCTGGTCTTTTGATGGGTGGCGCACGGCAGGTCGCC
+AGATGGTCCTGGCAACATCGCCGCTATGGTCGCTGGCCGCTGCGTATCTTGCTGGTGCTT
+CTGCTGGTGCTCATCATTCTGGTGGGCGCAGGCTACGGTTTGTTGCGCGGTAGCCTGCCG
+CAAACCGAAGGCACGGTGCGTCTACCCGGTCTGGGTGGACGGGTCGTAGTGACGCGAGAT
+GCCCAGGGCGTGCCTACTATTCGCGCACACAATGCGCTCGATGCCTGGCGGGTGCTGGGG
+TATCTCGAAGCGCAGGACCGTTTCACGCAGATGGATTTCATGCGCCGAGTCGCGGCAGGT
+GATCTGGCGGCCCTGGTTGGGCCGGCGGCATTGCCGTTGGATCGTATTCATGCGCGGTTT
+GATCTGCGCGCGCGTGCCGAACGCATCTATCTGGATGCGCCATCGGTCGAGCGGGCTCGC
+CTTGAGGCTTACACCCTGGGCGTGAACGAGGGGCTCGACAATCTGTCTGTACGTCCCTGG
+GCGTACCTGTTGCTGGGTGAGCGACCGCGTGCCTGGGAGCCCGCCGATTCTGTACTGGTG
+ATCTACGCCATGGGCTGGATGCTCCAGAATCCACTCGGCCCCAGGATGCGCGCACGTGCG
+GCATTGCGTAGCCTCTATCCACCAGCAGTGACGGCCTTTCTGGGAGCGCCGGATACGCAC
+TGGGCGGCGCCCATGGCAGGGCAACCGCCAGCTTTGCCTCCGGTGCCCGGCACACAGCTC
+ATCAATTTGTCAGCATCGGGAAAATCCAGGGCAACGGCACCTGTGCCGAGCACGGCGATG
+TACGCAGACACGGTAGCCAAACTGATTTTGCCGCAACCTTTTCCGGGTTCGAACAGCTTT
+GCCGTAAGTGGAGATTTGACTGGAACCGGTCACGCCTTGTTGGCCAACGACCCGCATCTG
+AGTTTGCGTGTGCCGGCAACCTGGTATCGAGCCAGACTCATCTATCCCGCGCCCGGCGCT
+ACGGCCAGTCAACCGGTTGAACTGACGGGCGTGTTTTTACCCGGCGTACCTGCACTGGTT
+ATTGGCACCAATGGCCACATTGCCTGGGGGCTGACCAACAGTGGCGGTGACTGGACTGCG
+CTCGTGCGCGTCAAAGCGACGGCGGCCGGGTCCCGAGGCGGGCCGCTGGTGTATGCCACG
+CCGAGCGGTACGGCGACGTTGGCGATTCAGCATGTGCTATTGAAGGTGCGCGGTCAGACG
+GCTCGTCCCATGTCGATTCGACGCACGATATGGGGTCCGGTTATCGGTACGACCGCAGAT
+GGGGCGTTGCTGGTTTCGCACTGGGCACTGGCGCAACCGGGCGGAGTGAATCTCCGCTTC
+ATGCAACTCGACAGCCAGACGACGGTTAAACAGGCGTTGATGGTGGCCGGCAGTGCCGGT
+ATTCCGGTACAGAATTTTCTGGTTGCCGATGATCAAGGGCACATTGGCTGGACGCTGGCA
+GGACGTATTCCCGTGCGCAAGGCCGGATGCGATTACGCAGTGCCGCAATCCTGGGCTGAT
+GGCAGCTGCGGGTGGACCGGCTGGTTGGCGCCCGGCAGTTATCCGAGCATTGTGGATCCC
+GCGCAGGGCTATCTTGCGACCGCGAACAATCGAGTTGATGCACGCACTGCGGCGGTGCTT
+GCGTTAGGCGACGAAAATTTTGCCGATGGGGCCCGAGCGCATCAGATTGTTTCAGACCTG
+AAGGCGTTGGCAAAACGGGGCAAAATCACGGCCAATGACCTTCATGACGTGCAATTGGAT
+GACCGCGCGCAATTTCTGCAACGTTGGCATGATTTGTTGTTGAATGTGTTGTCGCCATCG
+GCGCTCGAATTCCATCCGCATCGGCAAGCGTTACGCGAAGCGGTGGTGAATTGGGGCGCA
+CGTGCCGCTGTCGATTCCGTGGGCTATCGTATGGTGCGCGCGTTCCGTAATGAAGTGGCT
+GCTTCGATGTTCATGCCGATATTGAAACGGTTGCATACCCGCGATCCGGGTGCGGGTCTG
+CCTTTTTCCAACCAACTCGAAGGGCCGTTGTGGCGTCTGCTTCAGGTGCGTCCGCATAAC
+TGGCTGAACCCGGCATATCCCACCTGGAATGCCTTGCTGGTGCATGCGGCTGACGCAGTG
+ATCCATCGGTTCTGGAATCCGGTCAGCGGTCTTGCCGATGCGACATGGGGGGCACGCAAT
+ACCGTGCGTATAAATCAGCCGTTGGCGGTGGCGCTGGGGCCGTTGGGGCATTGGCTGGAC
+ATGCCGCCGACGCAACTGCCCGGCGATAGCAACATGCCGCGTGTACAGACGCCGGATTTC
+GGAGCTTCCATGCGCATGGTGGTGTCACCACAACCGAGTGCTCCCGGTTTGTTCGAACTG
+CCGGGTGGCGAAAGTGGACACCCGTTATCGCCCTGGTACAGCGATGAATTCAAGGCGTGG
+GCCGAGGGGCTGCTGACACCGCTTGCGCCGGGACCAGCGCGAAAGACCTTGCGTTTTATT
+CCATGGAGTCGGAGGGTGTCTGACCGGCCGACTGTGTCAACAGGCTCCGTGGTCCCAGCG
+CAGTCTGGGCAGTGATTTCAAGCTCGCGCCTCTCCAGCCATTCGAGCAGCGGCACCCAAG
+CCATGCGTTCGCCGCCGATACGTCGGCGTGGCAATTCGTGCAAACCCAGGCCACTGAGGA
+TTGCGTGGCTATAAGCCTGCAGATCATGCAGTGTGGCAATGAGCGGGATGTCGAGTGCGG
+AGATGAATTTTTGCAGGCGCTCGGCGCCGAGTGTGCCACGGCGAACGCGGTTGGCGATTA
+CGGCCATGCGGCCTGAATGACGGCCAAGCTTGGCAATCAATAATAGATCGGCCACTGTGC
+GTGCGGCCGCATCGCTGTCCATGGTGCCGGGCAATACCGGGATCAACACGGCCGCTGCGC
+CGCGTACAGTATCGGCCAGTGCGATTCCGCTCAGTCCTGCCGGCGTATCTACAACCAGGC
+GTTCCGTGTCCCGTGGAATGCGTAGTGCGTAACTCAGGGTTACGCCCGAGGTTTGATTGG
+GCAGACTCAGGGTGTGAATGGACGGAAGCGATTCAGGACGGCGTCGCAACCAGCTTGTGG
+CTGCCCGTTGCGGGTCGAGGTCCAGCAGGCAGGTTTTATACCCTTCGCTTGCCCAGAAGG
+CCGCAAGCGTTGTCGAGACGGTGGTCTTCCCGCTGCCGCCTTTCAAGTTGGCGATGACGA
+TCTTTTTCATCATCGATTCCGATGAATTGTCCAGGTTAGTTTACTGCCTTGCCGCATGTA
+CTGTGCGATCATCTGTTTGCATATGTGTTGAAGTACACTAAACCGATGTCAATAACAGCC
+TTAATTCTGCAAGGTGGTGGGGCGCGCGCGGCTTATCAGGCCGGAGTGCTGGCGGGTATA
+GCCGAGTGGTACGGCGAGGATGAGGCCGTACCTTTCCGGGTTATTTCGGGAACGTCGGCG
+GGTGCCATGAATGCCGCCTATCTGTCGGCCAACATGGAAAATTTTGCGCACGGCACACAG
+CGTTTGGCCCAAGTGTGGTCGCAACTGGAAGCGCAGCAGGTTTATCGACCAGAATACCGC
+AAGGTGTTTGGTGCCTTATTGCATTGGGCCTGGTCGCTACTGTCCGGCGGGTTGGGGGAT
+TCCAATCCGCGTTCCTTGCTGGATAATTCGCCGCTACGCGCCTTGCTGGCCGAGAATATA
+GATTTTGACGCTATTGCGCGCAATATCGAGCGTGGCCTCCTGCGCGGTGTGTCGGTGACA
+GTGGCGGGATACAGCACAGAACGTTCACTGAGTTATTTTCAGGCTGAAACCGGAGTACAG
+TCCTGGTGGCGGCAACGACGGGAAGGACGCCCGGTGCAAATGACGCTCGACCATGTCATG
+GCTTCACTGGGACTGCCCATAATTTTCCCTGCCGTGAAAGTTGCCGGCGAGTGGTGCGGG
+GATGGTTCTACCCGAGAGTTCGCTCCGTTATCGCCAGCAATTCACCTGGGAGCAAAGCGG
+GTGCTGGTGATTGATACACAGTATCCTGCGCCACAGCATGTGCTAGGTCAGGACCAGGCA
+TATCCTTCATTGTCAAAAATAATGGGCTATCTGTTCGATTCCGTGTTTTCGGATAGCCTG
+TATGCCGATCTGGAACGAACCAAACGCATTAATCGCACGTTGGATTACATCAAGAGGCAG
+AGTGGGCACGAGCCCCCTGAGTTGGGTTTGAGCCACATCGACACTTTGGTGATTGCACCA
+TCGCGTCGTCCATTGGAGATTGCCAGCCGCTATGAATCGCATTTGCCCAAATCCATGCGT
+TGGATTCTGCGTTCTCTGGGCGGTGATGTGAGTAGTGGAGATCAATTGCTCAGTTACATG
+CTTTTCCAGAGCGGCTATTGCAGCGAAATGGTGGCCTTGGGTCGGCACGATGCGCATGCT
+CGTCGTGAGGAGATTGGCCAGTTTCTCGGCTTGTCGAAAATCAAGGTACGCTGAATGACG
+TTTTAGTCGTCGGCAAGGATCGGTTTGACGTCTCGTGTCGGCGTATCCAGGTCACGATGG
+CGAACGGTCACGGCCCAGCCGCCGTGCGCGAGCTGTGCGGCCAATTGTTCCGCCATGTAA
+ACCGAGCGGTGGCGCCCGCCGGTGCAGCCGATGGCAATGGTGAGATAGCTGCGGTTGCTG
+GCGGCATAGCTGGGCAGCCAGGCGTTCAGGAAGTTCACCAGATTGCTCAGCATACGAGTG
+ACGGTGCCATGCGTTTCCAGGTATTCCGCGATGGGCTGGTCAAGCCCCGTCAATTCGCGC
+AGGGTGGGTTCCCAATAAGGGTTAGGCAGGCAACGCATGTCGAAAACCAGATCGGCATCT
+TGAGCCAGCCCTCGACGGTAACCGAATGATTCGATTTGCAATGCCATGGGATGATCGCCG
+CCTTCGTTCACGCGTGCCCGGATGATTTCGCGTAGCTGATGGATATTGGTATGCGTGGTG
+TCGATACAGGCGTCAGCCAATTGGGCTAAAGGTTCCAATAGCGTGGTTTCAATCTCGATT
+GCCGCAGCCAGGTCCGTGTCGGGGCCTGTCAATGGATGACGTCGCCGCGTGGCCCGATAG
+CGTTTGACCAGGGTGCCGGGTTCGCAAAACAAGTAGATTACGGTACAGCCGTGAGGGCGC
+GTCCGCCAGATTTCTATCTGGCGGGCCAAGGCTTCGAATTCTTCCGGTGTGTTATGTGGG
+GCAATACCGATCGCAAGCCGTGAATGGTGTCGGGCGTCATCGCCCAGCATGGCGTCAATC
+GCAGGTTCGATCAGCGACAGAGGCAAATTGTCGACAATCTGATAGCCGAGATCCTCGAGC
+ATATCGAGTGCGCCGGTTTTACCGGCACCTGAGAGTCCACCCAGCAAAATGAGATTCATT
+CGGGTGAGTTTAGCGTATGAGCGTACGGGGTGCCGGTTGGCCTCGTTCCGACACCTTGCG
+ACGGTGCCGGAACGAGGTTGGGTGAGGAAAGGAATGGATGAGTTCAGTTTTCCATATTCA
+GCCGCGCGGTTGGGGTGGCGTGATGGCTGGCATGCCGTTCCTTGTGGCGCACGAGTTGCC
+GGTCAAGCCTGTCAGCCAGTATATCGATGGCAGCATACATGTCTGTTTCGTTGGCCTCTG
+CGTAAACGGTTCCTCCACGTACTTGCAGAATGCCTTCCGCCTTGTGATCAAGGTTTTCGA
+CGCTGAGGATGATCTGCGTCGAAGTGGGGGGTTCGTGGTGTCGTCCGAGTCGCGACAGCT
+TGGTATTGACGTAATCCTTCAAGGCTGGTGTGACATCCAGATGGCGGCCGGTGATCGTGT
+TTTGCATAACGTTACCCCTTGCTGATAGCTACGGAATGAGCCGGACGTTTGCGCGCCCGA
+GTGGATGCGAAACCGAGGGCTTCGCGGTATTTGGCGACGGTGCGTCGTGCAATCGGCATG
+TTGTCCCTGGCCAGTGCCGCTGCCAGTGCAGCATCGCTCAGAGGAGCTGCAGGGTCTTCA
+TGGTTCAACAGATGGCGCAGACGTTCATGCACGGCACGGGCTGATATGGCTTCGTCATTA
+TCATTAGACAAGGCGTTGGAAAATAAGTGCCGCAAAGTAATGACCCCGCGAGGGGTGGAC
+ATGGCTTTCCCCTGTACGGCTCGGGATATGGTGGACTCATGCATGTCGAGTTCTTTTGCC
+ACTTCGCGCAACGTTAATGGCGCCAGATGCATGACCCCCTGATCAAGAAAGGCTGTCTGG
+CGCCTGACCAGCACACGTGCAACACGCAGCAGGGTGTTTTCGCGTTGAGCAAGGCTGCGT
+ATCAGCCAGCGGGCTTCTTCCAGTTGCCTGGTCAGGGATTGGGATGCCTCGTTGAGCCGG
+TTTGCGCTGAGCCAGGCGACATAGGTTGCGTTTATCGATATGCGGGGGTGATTGCCCGGA
+TAGAGTTCTACTTGCCAACCATCGGGTGTGCGGTAGGTGCGTAATTCCGGGATCAGGTAT
+TCAGCTGTTTGCGCGGAATAGTCGTTTCCTGGCCTCGGATTCAGGCTCTGTATCAGGCTC
+AACGCTCTGCGGACGCTGTCTTCATCGCTACAGGTCAGGCTTGCCAGCGTGGCCATATCT
+GCTTGGGTCAGGCGGGCGCAATGGCCGTCTATCAGTTCACGGGCGACAACCAGTCCTGCC
+GTATCCGGCGGCAAAGCTTCCAGTTGCAGGGACAAGCACTCGGCGGTATCGCGGGCGCCG
+ATGCCGATCGGGTCAAGGCGTTGGACACGGTGCAGTATGGCCTCGATTTCAATCAGTTCG
+GGGCTGGGATCGAGGGCATCAAGTTCCTGACTCACAGTGTCGAGATCTTCGCGCAGATAT
+CCGTTGTCATCCAGAGAGTCGACCAGGGCCAGTGCGATCAGGAAGTCGCGATCCGAGAAT
+CGCTCCAGAACGAGTTGTTCGATCAGGTGTTGGCGCAAATCGGGTGGACGAATATCTTCG
+AAAGTCTGCATGTCGGGGCGCTCCCCCGTGCCTGCACTGCTCGACCAGGACAACTCATCC
+CACTCGCCAGCAGGTTCGGTCTGCTCCATGACGGTGGCAACCTCAGGATCGCCTTCTCCA
+GTTTCAGGCTCAAGCCGTTCGAGCATGACGTTTTCTTCCAACGCCGTTTCCAGTATCTGT
+TCCAGATCCGGGCGCGGTAATGCCAGCAAGCGCAGGGCCTCGGTTTGGCGGGGTGAAAGG
+CCCAGGCGCTGGGATATCCCGGTTTGTAGACGCGGACTGGAATTCATGAGTGGAAAATCG
+TCATTCCCATGTCCCTAGTTATAGCGTAAATTTGTCGCCCAGGTAGATTTCCCTTACGGT
+TTGGTTGTCGGCGATTTCTTTCGGACTGCCTTCGGCCAGCATGGTTCCACGGTTCATGAC
+GTAGGCCCGGTTACAGATATCGAGTGTTTCACGCACGTTGTGTTCGGTGATCAAGACGCC
+GATGCCGCGTTTGGCCAGATGATCGATGATGCGCTTGATATCGGCTACCGATACCGGATC
+GACGCCTGCAAAAGGTTCGTCCAGCAGCATGAAGGCAGGTTCATTGGCCAGCGCCCGGGC
+GATTTCCACCCGTCGTCTTTCTCCGCCCGACAGGCTGATGCCCTTGTCCTTGGCCAGGTG
+CGTCACGCCGAGTTCATCGAGCAACTCATCGGCGCGACGTTGTTGCTCCGCGCGGGTGCC
+GTGCCCACCCAATTCCAGCACGGCAATCAGATTGTCACGCACGCTCAGGTTGCGGAAGAT
+CGAAGCTTCCTGAGGCAGGTAGCCGAGTCCGGCGCGAGCGCGGGCATGTATGGGCAGGCC
+GGTTATATCGCGCTGATCCAGGTAAATATTGCCGCTGTCTGTGGGCACCAGGCCCAGGAT
+CATGTAGAAAGTCGTGGTCTTGCCGGCACCGTTGGGGCCAAGCAGGCCGATGATCTCGCC
+GGAATTGACGTTGAGGTTCAGCCCGCGCACGACCTCGCGGGTGCGATAGCGTTTGTGCAG
+GTTCTCGGCGCGTAGTTGGCTCATGGTGAGGTACGCGCGGCCGGGCTCAGTACGGCGTGT
+ACACGGCCGTTGCCATTGCCACTGGCTTCGAGCTGGCGGGTGGCGATGCGGTACGTGATG
+TGCGCGGCGGAAAAATGTTCGCCCGGGCGCGAAAAATGCACCTGTCCGTCGAGCTGCAGG
+ATATCGGTTTTTCCGTTGTATGTGATGGAATCGGCTTCGCCGAGTACGTGCGGTTTTCCG
+GGTTCGCGCAATTCAAACCGGGCGGGTGTACCGGTTACAACGACCTTGCCAATGGTATTG
+GATCGACCATGAATGACAGCGGAATGCCCGTACAGGCGCAGTGCGCCACGTGTAACGATC
+ACATGTCCCGAATAGGTCACCTCGGTGCCTTGTCCGGTGGTGTTGGCCATGGATGAGTGA
+TCGGCATTGATGGTCATCACGCCAGACACCGAAGACGAGGCGTTGGCCGACCCCGGAGCG
+GGCGTGCCCAGTGCGGGAAAGGCGCAACAAGCCAGGAGGGCGGTGCAGCAGGCGAACAAC
+TTAGGGTGCATATTGACTGGTAACATCCTTGAGCAAAGACAGCGTACCGGTTTGCAGGTT
+CGCGGCCAAGCCCGTGCCTCGTGTTTCCCGGTGTCCCTGGCGCAGGATCACGCGGTAGCG
+GCTGGCGAGGCGCGCCTCGGGCAGCAGCACGGTGACTTCGGTGGTCAGGAAATGCACGGG
+TATGGGTGTATCGAGTTCATGCGCCCGCACATGACCAATCAGATTCAGCCGGGTACCGTT
+TGCGAACAGGCGGCCGTTATCGGATTGCAAATGCCAGGGTTTGCCGTGAACGGGAAAGTA
+GTCGAGATCGACGCGGGTGAGCAGGGCAATATTGTTGCGTGGCATGTGTGCGATACGGCG
+TGCTTTGATGATGTAGCGCCGGGAGCCGTCCTTGGCGAAGCGGGTAACTATGGCTTGATG
+GAGCAGGTAGTCGGGGCGCTCTACGGCATGGGATGCCAAGTCGGTCGCGGGGGAATGGTC
+ATGACTGCGCAGGAACAGCCAACTTGTCAGGGCCGCAGCACCGAGCAAAGCTGCCCAGGC
+GCTGGCGACGGCCCAGCCGCGCGATAGCCTCACGACTTGCCGCCCGCGTTGGCCTGACGG
+GCGGCGAGCAAGCGCTCGCAAACCTCCCGTACCGCACCTTGGCCGCCCGTTGCTTGCGTA
+CACCAATCGGCCTCATCGCGAACCCGGGCCACGGCATTAGCCGGAGCAATGCGCAAGCCC
+GCTATGGCAAAAGCGGGCAAATCGGCTTCATCGTCGCCCATGAAGGCGCAGAATGCGAGT
+CTGACGCCAACGGCTTGGGCAGTCTCGGTCAGGCAATGTCCCTTGTCCTTGACGCCCTGA
+TGAACCTGGATAATACCCAATTCCCGAGCGCGATGCGTGACGATGGGAGACTGACGCGCG
+CTGATCAGAGCCACGGCAATGCCTTCGCGCATCAGCCGTTTGATGCCGGCACCGTCATGG
+GCGTTGAAGGCCTTGATTTCGCCAGCCGTTTCCGAATACCAGAGGCGTCCGTCGGTCAGC
+ACACCGTCCACATCCAGTGCCAGCAGACGGATAGCGGCCAGTGGCGTACTCATACCACCC
+CCGCTTGCAGCAAGTCATGCATGTTGAAGGCACCGACGGGTTTGTCATCCGTGACCACCG
+GCAGGCTGTTGATATGGCGGGTTTCCATTAGCCGCAGGGCCTCTGCTGCGAGCATATCGG
+GCGTAGCCACGGTACATTCGCGCGTGATCAGATGTTGCATGGGGGTATCGAGATTGACGC
+CCTGGTCCAGGTGACGGCGCAAATCGCCATCGGTAAACACCCCCGCGAGCCGGCCTTGCA
+CATCGGTGATCATTGCCATGCCGAGTCCTTTGGCGCTCATGGTGACCAATGCGTCGCCCA
+GGCGCGTACTTTCGTTAATGATCGGCATGGCGTCATCGGTATGCATGATGTCGGCGACAC
+GGACCAGTAGCCGTCGGCCGAGTCGACCGCCGGGATGCGAGCGGGCAAAATCCTCGGGAG
+TGAAACCGCGGGCCGCGGATACGGCCAGAGCCAACGCATCGCCCATGGCCAGCGTGGCGC
+TGGTGCTTGCCGTGGGGGCGAGGTTCAGGGGGCAAGCCTCTCGCGATACGGAAATATCGA
+GGTGGCAGTCGGAGGCGCGCGCGAGCATCGAATCGGGTTCTCCGGTCAGCGCGATCAGTG
+CTACGCCCAGGCGTTTGATCAGCGGCACGATGGTGACCACTTCGGGGGTCTGGCCGGAAT
+TCGACAAGGCAATCATCACATCCTCAGATGTAATCATGCCCAGGTCGCCATGGCTGGCTT
+CCGCAGGATGTACGTAAAAGGCAGGGGTTCCCGTGGAGGCCATGGTGGCCGCGAGTTTGC
+GCCCGATGTGCCCGGATTTTCCCATGCCGGTGACCACGACACGCCCGCGGCAGGCCAACA
+GGAGTCCACAGGCGGCGGCAAAGGTTTCATTCAGTCGCGACTCCAGGGCGGATACCGCAG
+CGGCTTCAATCTGGATGACTTCGCGCCCGGACTCGATCAAACCGGTCGCTGACGCAGGAC
+GGTTCACAAACACTTCTCCGATAGTGGTGCGCCCATTTTAGCCGCACGGCGCTCTGGTAA
+ACTTGGTGGTCTCAGTCAAGTGGAAATTGCATGGACCGGACAGACTTGCAGCAGCTCCTG
+GAACAGGCGTTCCCAAACGCTGAAATCGAGGTCCAGTCCGAGGATGGCGTACATTTTGCG
+GCCCGTCTGATCGATGCCGGATTCTCCGGGCAGGGACGCCTGGCCCGCCATCAGACCGTC
+TATGCGGCGTTGGGCGCGCGGGTTGGCGGGGAGATTCATGCATTATCCCTGCAGACGTTG
+ACCCCCGAAGAAGCCGGAGCCCGCGCTTGAACCGGCTGTTGATACGTGGTGGGGGCCGAT
+TGGACGGAGAAATCCGTATCTCCGGTGCCAAGAATGCCACCTTGCCCATTCTTGCCGCGT
+CACTGTTGGCCGAAACACCGATCACCATCGGCAACGTTCCGCATCTCCATGACGTGACTA
+CCACCGTAACCTTGTTGCGCCGGATGGGTGTGGATGTCACGGTGGGCGAACATATGGCGC
+TGGAAGTCGATTCCAACACTATCAAGGACATGGTTGCGCCTTATGAACTCGTGCGTACCA
+TGCGCGCCTCCATTCTGGTGCTGGGGCCGTTGCTGGCCCGTTTCGGATGCGCCGAGGTCT
+CGTTGCCCGGCGGTTGCGCTATCGGTTCGCGTCCGGTTGAGCTGCACCTGAAGGGTTTGT
+CCGCCATGGGGGCCGATATCGATGTGCGTAACGGCTACATCTATGCGAAAGCGAACCGTT
+TGCGCGGTGCGCGGATATTCATGGATATGGTCTCGGTGACCGGCACCGAGAACCTGATGA
+TGGCTGCGGTGCTGGCCGATGGTGAAACGGTTATCGAGAATGCTGCGCGCGAACCGGAAG
+TCGTTGATCTGGCCAATTGTCTGAACAAGATGGGCGCCGAAATCGAGGGTGCCGGCACCG
+AGACCTTGCATATCCAGGGCGTGGCCAAGCTCGAAGGGTGTTATTACGAAGTGATGCCTG
+ATCGTATCGAAACCGGCACCTATCTGGTGGCGGGCGCCCTGACCGGTGGTCGGGTGCGCG
+TCAAACGCACCCGACCCGACATGATGGAGTCAGTACTCGAGAAGCTGCGTGAAGCGGGTG
+CCGAAATCACCAGCAAGGATGATTGGATCGAGCTCGACATGAAAGGCCGCCGCCCACAGG
+CCGTCACCCTGCGCACGGCACCATATCCCGCGTTCCCCACAGACATGCAGGCCCAGTTCA
+CGGCTTTGAACGCAGTGGCCGAAGGCAGTGGTGCAGTTACCGAAACCGTGTTCGAGAATC
+GTTTCATGCACGTACAGGAATTGGTACGCATGGGAGCGCGCATCCAACTCGAAGGCAACA
+CCGCCATGATTCAGGGGGTAGAACGTTTAACAGGCGCGCCGGTGCTGGCAACCGACCTGC
+GTGCATCGGCCAGCCTGGTGCTGGCGGGTTTGGTTGCGGAAGGCGAAACCGTGGTGGACC
+GCATCTACCATATTGACCGCGGTTACGAATGTATCGAGGAAAAGCTGGCGCAACTGGGCG
+CGCACATCCGCCGCGTTACCTCATGAATATTGAACGTCTTCGATCCCGGTCTACCCCACG
+CTTGCCATGGCTAGGCTCTATAATCAAGGCGTTCTTGCCACCGCGGCTCTCATGATCCTT
+TACTCACGACCCGATGATCCTGCTGCCCACAGTATCCGTTTGGTACTGGCGGAAAAAGCA
+ATCGGCGTCAAAATCGTGGAAGTCGAACCCGACTCGCCACCGGAAGATTTGCTGCACCTG
+AATCCTTACGGCACCCTGCCGACACTGGTCTCGCGAGAAGTCGTCCTGTACGATCCGCGC
+ATCATTGCCGAATTCATTGATGAGCGTTACCCGCATCCGTCGTTGTTGCCCAGCGATCCG
+GTGCTGCGTGCGCGAGCACGTTTGTTTGTCAGCGAGATTGGCGGAAGCTGGTACGAGTTA
+TGTGACGAAGTCGCCAACGGTGCCGGTCGCGGACGTACACGCGCCCGACGCGAGCTGACC
+GAAGCGGTGGTCTCCAGTGACGAGTTGTTTACCGGCACGGCATATCTGCTGGGCGGAGAC
+TATGGACTCGCCGATTGCGTGGCGGCGCCCGTGCTTTGGCGTTTGCCGCATCTGGGTGTG
+CGTTTGCCACGCGAAGCGAAAGCCATTCGCGGCTATATGCAGCGGGTATTCAAGCGTCCG
+ACCTTTGTGTATGCCCTGGTGGCTTCCGAACGGGCCATGATCGAAAGCTGACCTCTGCCG
+CATGACCGAAAAGCCCCGTCCGTCCCGCAAGCCCTACCTTGTTCGCGCCCTCCATGAGTG
+GATGGGGGATGCCAGCTTGACGCCACAAATCATTGTTGATGCAACCGTGGACCATGTCGA
+TGTTCCTGTCGAGCATGTACATGATGGCAAAATCGTGTTGAACCTGAGCCTGGAAGCGGT
+GCGCGATCTCGAACTGGGGAATGACGCAATCACCTGCACGGCCCGGTTTGGCGGTGTGGC
+CCGATCATTATGGGTGCCCATGAAGGCTGTGCTGGGGATTTATGCGCGCGAGACCGGCGA
+AGGCGTGGCGTTTGCGTGTTCCTAGGCTGTTTCCTGGTGGGATCCTCTAGAGTCGACCTG
+CAGGCATGCAAGCTTGAGTATTCTATAGTCTCACCTAAATAGCTTGGCGTAATCATGGTC
+ATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGG
+AAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTT
+GCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGG
+CCAACGCGAACCCCTTGCGGCCGCCCGGGCCGTCGACCAATTCTCATGTTTGACAGCTTA
+TCATCGAATTTCTGCCATTCATCCGCTTATTATCACTTATTCAGGCGTAGCAACCAGGCG
+TTTAAGGGCACCAATAACTGCCTTAAAAAAATTACGCCCCGCCCTGCCACTCATCGCAGT
+ACTGTTGTAATTCATTAAGCATTCTGCCGACATGGAAGCCATCACAAACGGCATGATGAA
+CCTGAATCGCCAGCGGCATCAGCACCTTGTCGCCTTGCGTATAATATTTGCCCATGGTGA
+AAACGGGGGCGAAGAAGTTGTCCATATTGGCCACGTTTAAATCAAAACTGGTGAAACTCA
+CCCAGGGATTGGCTGAGACGAAAAACATATTCTCAATAAACCCTTTAGGGAAATAGGCCA
+GGTTTTCACCGTAACACGCCACATCTTGCGAATATATGTGTAGAAACTGCCGGAAATCGT
+CGTGGTATTCACTCCAGAGCGATGAAAACGTTTCAGTTTGCTCATGGAAAACGGTGTAAC
+AAGGGTGAACACTATCCCATATCACCAGCTCACCGTCTTTCATTGCCATACGAAATTCCG
+GATGAGCATTCATCAGGCGGGCAAGAATGTGAATAAAGGCCGGATAAAACTTGTGCTTAT
+TTTTCTTTACGGTCTTTAAAAAGGCCGTAATATCCAGCTGAACGGTCTGGTTATAGGTAC
+ATTGAGCAACTGACTGAAATGCCTCAAAATGTTCTTTACGATGCCATTGGGATATATCAA
+CGGTGGTATATCCAGTGATTTTTTTCTCCATTTTAGCTTCCTTAGCTCCTGAAAATCTCG
+ATAACTCAAAAAATACGCCCGGTAGTGATCTTATTTCATTATGGTGAAAGTTGGAACCTC
+TTACGTGCCGATCAACGTCTCATTTTCGCCAAAAGTTGGCCCAGGGCTTCCCGGTATCAA
+CAGGGACACCAGGATTTATTTATTCTGCGAAGTGATCTTCCGTCACAGGTATTTATTCGC
+GATAAGCTCATGGAGCGGCGTAACCGTCGCACAGGAAGGACAGAGAAAGCGCGGATCTGG
+GAAGTGACGGACAGAACGGTCAGGACCTGGATTGGGGAGGCGGTTGCCGCCGCTGCTGCT
+GACGGTGTGACGTTCTCTGTTCCGGTCACACCACATACGTTCCGCCATTCCTATGCGATG
+CACATGCTGTATGCCGGTATACCGCTGAAAGTTCTGCAAAGCCTGATGGGACATAAGTCC
+ATCAGTTCAACGGAAGTCTACACGAAGGTTTTTGCGCTGGATGTGGCTGCCCGGCACCGG
+GTGCAGTTTGCGATGCCGGAGTCTGATGCGGTTGCGATGCTGAAACAATTATCCTGAGAA
+TAAATGCCTTGGCCTTTATATGGAAATGTGGAACTGAGTGGATATGCTGTTTTTGTCTGT
+TAAACAGAGAAGCTGGCTGTTATCCACTGAGAAGCGAACGAAACAGTCGGGAAAATCTCC
+CATTATCGTAGAGATCCGCATTATTAATCTCAGGAGCCTGTGTAGCGTTTATAGGAAGTA
+GTGTTCTGTCATGATGCCTGCAAGCGGTAACGAAAACGATTTGAATATGCCTTCAGGAAC
+AATAGAAATCTTCGTGCGGTGTTACGTTGAAGTGGAGCGGATTATGTCAGCAATGGACAG
+AACAACCTAATGAACACAGAACCATGATGTGGTCTGTCCTTTTACAGCCAGTAGTGCTCG
+CCGCAGTCGAGCGACAGGGCGAAGCCCTCGGCTGGTTGCCCTCGCCGCTGGGCTGGCGGC
+CGTCTATGGCCCTGCAAACGCGCCAGAAACGCCGTCGAAGCCGTGTGCGAGACACCGCGG
+CCGGCCGCCGGCGTTGTGGATACCTCGCGGAAAACTTGGCCCTCACTGACAGATGAGGGG
+CGGACGTTGACACTTGAGGGGCCGACTCACCCGGCGCGGCGTTGACAGATGAGGGGCAGG
+CTCGATTTCGGCCGGCGACGTGGAGCTGGCCAGCCTCGCAAATCGGCGAAAACGCCTGAT
+TTTACGCGAGTTTCCCACAGATGATGTGGACAAGCCTGGGGATAAGTGCCCTGCGGTATT
+GACACTTGAGGGGCGCGACTACTGACAGATGAGGGGCGCGATCCTTGACACTTGAGGGGC
+AGAGTGCTGACAGATGAGGGGCGCACCTATTGACATTTGAGGGGCTGTCCACAGGCAGAA
+AATCCAGCATTTGCAAGGGTTTCCGCCCGTTTTTCGGCCACCGCTAACCTGTCTTTTAAC
+CTGCTTTTAAACCAATATTTATAAACCTTGTTTTTAACCAGGGCTGCGCCCTGTGCGCGT
+GACCGCGCACGCCGAAGGGGGGTGCCCCCCCTTCTCGAACCCTCCCGGTCGAGTGAGCGA
+GGAAGCACCAGGGAACAGCACTTATATATTCTGCTTACACACGATGCCTGAAAAAACTTC
+CCTTGGGGTTATCCACTTATCCACGGGGATATTTTTATAATTATTTTTTTTATAGTTTTT
+AGATCTTCTTTTTTAGAGCGCCTTGTAGGCCTTTATCCATGCTGGTTCTAGAGAAGGTGT
+TGTGACAAATTGCCCTTTCAGTGTGACAAATCACCCTCAAATGACAGTCCTGTCTGTGAC
+AAATTGCCCTTAACCCTGTGACAAATTGCCCTCAGAAGAAGCTGTTTTTTCACAAAGTTA
+TCCCTGCTTATTGACTCTTTTTTATTTAGTGTGACAATCTAAAAACTTGTCACACTTCAC
+ATGGATCTGTCATGGCGGAAACAGCGGTTATCAATCACAAGAAACGTAAAAATAGCCCGC
+GAATCGTCCAGTCAAACGACCTCACTGAGGCGGCATATAGTCTCTCCCGGGATCAAAAAC
+GTATGCTGTATCTGTTCGTTGACCAGATCAGAAAATCTGATGGCACCCTACAGGAACATG
+ACGGTATCTGCGAGATCCATGTTGCTAAATATGCTGAAATATTCGGATTGACCTCTGCGG
+AAGCCAGTAAGGATATACGGCAGGCATTGAAGAGTTTCGCGGGGAAGGAAGTGGTTTTTT
+ATCGCCCTGAAGAGGATGCCGGCGATGAAAAAGGCTATGAATCTTTTCCTTGGTTTATCA
+AACGTGCGCACAGTCCATCCAGAGGGCTTTACAGTGTACATATCAACCCATATCTCATTC
+CCTTCTTTATCGGGTTACAGAACCGGTTTACGCAGTTTCGGCTTAGTGAAACAAAAGAAA
+TCACCAATCCGTATGCCATGCGTTTATACGAATCCCTGTGTCAGTATCGTAAGCCGGATG
+GCTCAGGCATCGTCTCTCTGAAAATCGACTGGATCATAGAGCGTTACCAGCTGCCTCAAA
+GTTACCAGCGTATGCCTGACTTCCGCCGCCGCTTCCTGCAGGTCTGTGTTAATGAGATCA
+ACAGCAGAACTCCAATGCGCCTCTCATACATTGAGAAAAAGAAAGGCCGCCAGACGACTC
+ATATCGTATTTTCCTTCCGCGATATCACTTCCATGACGACAGGATAGTCTGAGGGTTATC
+TGTCACAGATTTGAGGGTGGTTCGTCACATTTGTTCTGACCTACTGAGGGTAATTTGTCA
+CAGTTTTGCTGTTTCCTTCAGCCTGCATGGATTTTCTCATACTTTTTGAACTGTAATTTT
+TAAGGAAGCCAAATTTGAGGGCAGTTTGTCACAGTTGATTTCCTTCTCTTTCCCTTCGTC
+ATGTGACTTGATATCGGGGGTTAGTTCGTCATCATTGATGAGGGTTGATTATCACAGTTT
+ATTACTCTGAATTGGCTATCCGCGTGTGTACCTCTACCTGGAGTTTTTCCCACGGTGGAT
+ATTTCTTCTTGCGCTGAGCGTAAGAGCTATCTGACAGAACAGTTCTTCTTTGCTTCCTCG
+CCAGTTCGCTCGCTATGCTCGGTTACACGGCTGCGGCGAGCGCTAGTGATAATAAGTGAC
+TGAGGTATGTGCTCTTCTTATCTCCTTTTGTAGTGTTGCTCTTATTTTAAACAACTTTGC
+GGTTTTTTGATGACTTTGCGATTTTGTTGTTGCTTTGCAGTAAATTGCAAGATTTAATAA
+AAAAACGCAAAGCAATGATTAAAGGATGTTCAGAATGAAACTCATGGAAACACTTAACCA
+GTGCATAAACGCTGGTCATGAAATGACGAAGGCTATCGCCATTGCACAGTTTAATGATGA
+CAGCCCGGAAGCGAGGAAAATAACCCGGCGCTGGAGAATAGGTGAAGCAGCGGATTTAGT
+TGGGGTTTCTTCTCAGGCTATCAGAGATGCCGAGAAAGCAGGGCGACTACCGCACCCGGA
+TATGGAAATTCGAGGACGGGTTGAGCAACGTGTTGGTTATACAATTGAACAAATTAATCA
+TATGCGTGATGTGTTTGGTACGCGATTGCGACGTGCTGAAGACGTATTTCCACCGGTGAT
+CGGGGTTGCTGCCCATAAAGGTGGCGTTTACAAAACCTCAGTTTCTGTTCATCTTGCTCA
+GGATCTGGCTCTGAAGGGGCTACGTGTTTTGCTCGTGGAAGGTAACGACCCCCAGGGAAC
+AGCCTCAATGTATCACGGATGGGTACCAGATCTTCATATTCATGCAGAAGACACTCTCCT
+GCCTTTCTATCTTGGGGAAAAGGACGATGTCACTTATGCAATAAAGCCCACTTGCTGGCC
+GGGGCTTGACATTATTCCTTCCTGTCTGGCTCTGCACCGTATTGAAACTGAGTTAATGGG
+CAAATTTGATGAAGGTAAACTGCCCACCGATCCACACCTGATGCTCCGACTGGCCATTGA
+AACTGTTGCTCATGACTATGATGTCATAGTTATTGACAGCGCGCCTAACCTGGGTATCGG
+CACGATTAATGTCGTATGTGCTGCTGATGTGCTGATTGTTCCCACGCCTGCTGAGTTGTT
+TGACTACACCTCCGCACTGCAGTTTTTCGATATGCTTCGTGATCTGCTCAAGAACGTTGA
+TCTTAAAGGGTTCGAGCCTGATGTACGTATTTTGCTTACCAAATACAGCAATAGTAATGG
+CTCTCAGTCCCCGTGGATGGAGGAGCAAATTCGGGATGCCTGGGGAAGCATGGTTCTAAA
+AAATGTTGTACGTGAAACGGATGAAGTTGGTAAAGGTCAGATCCGGATGAGAACTGTTTT
+TGAACAGGCCATTGATCAACGCTCTTCAACTGGTGCCTGGAGAAATGCTCTTTCTATTTG
+GGAACCTGTCTGCAATGAAATTTTCGATCGTCTGATTAAACCACGCTGGGAGATTAGATA
+ATGAAGCGTGCGCCTGTTATTCCAAAACATACGCTCAATACTCAACCGGTTGAAGATACT
+TCGTTATCGACACCAGCTGCCCCGATGGTGGATTCGTTAATTGCGCGCGTAGGAGTAATG
+GCTCGCGGTAATGCCATTACTTTGCCTGTATGTGGTCGGGATGTGAAGTTTACTCTTGAA
+GTGCTCCGGGGTGATAGTGTTGAGAAGACCTCTCGGGTATGGTCAGGTAATGAACGTGAC
+CAGGAGCTGCTTACTGAGGACGCACTGGATGATCTCATCCCTTCTTTTCTACTGACTGGT
+CAACAGACACCGGCGTTCGGTCGAAGAGTATCTGGTGTCATAGAAATTGCCGATGGGAGT
+CGCCGTCGTAAAGCTGCTGCACTTACCGAAAGTGATTATCGTGTTCTGGTTGGCGAGCTG
+GATGATGAGCAGATGGCTGCATTATCCAGATTGGGTAACGATTATCGCCCAACAAGTGCT
+TATGAACGTGGTCAGCGTTATGCAAGCCGATTGCAGAATGAATTTGCTGGAAATATTTCT
+GCGCTGGCTGATGCGGAAAATATTTCACGTAAGATTATTACCCGCTGTATCAACACCGCC
+AAATTGCCTAAATCAGTTGTTGCTCTTTTTTCTCACCCCGGTGAACTATCTGCCCGGTCA
+GGTGATGCACTTCAAAAAGCCTTTACAGATAAAGAGGAATTACTTAAGCAGCAGGCATCT
+AACCTTCATGAGCAGAAAAAAGCTGGGGTGATATTTGAAGCTGAAGAAGTTATCACTCTT
+TTAACTTCTGTGCTTAAAACGTCATCTGCATCAAGAACTAGTTTAAGCTCACGACATCAG
+TTTGCTCCTGGAGCGACAGTATTGTATAAGGGCGATAAAATGGTGCTTAACCTGGACAGG
+TCTCGTGTTCCAACTGAGTGTATAGAGAAAATTGAGGCCATTCTTAAGGAACTTGAAAAG
+CCAGCACCCTGATGCGACCACGTTTTAGTCTACGTTTATCTGTCTTTACTTAATGTCCTT
+TGTTACAGGCCAGAAAGCATAACTGGCCTGAATATTCTCTCTGGGCCCACTGTTCCACTT
+GTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATT
+ATTAGTCTGGGACCACGGTCCACTCGTATCGTCG
+>NODE_21_length_3078_cov_41.6478_ID_41
+GTAAGGGGGGATAGCAAAGAGGGGGGATGGGGCGGTGGCCCGGGAGGTTTCGGGTGCCGC
+CTGCCTTGACATAACGAGCCCAAGCGGAGAGATGACCGAGTGGCCGAAGGTGCTCGCCTG
+CTAAGCGAGTGAGGGGTGACAAGCTCCTCCGAGGGTTCGAATCCCTCTCTCTCCGCCATC
+AGATATCACAGGGCCTGGGCCGTCCGGCCCGGGCCCTGTTCCTTTACCCTCTCACCCGCT
+AGGGGCAAGCCGCGTGCTCTTCACCCAGATCATAGCCTTCGTCCTGGTCATGGTGGTCTA
+CCAGGCCTACGACCCCGCCCCGCCGGACTACGGCTGGGGCTGGGGGCTTTTGCTTTTCAT
+CACCGGCCCCCTGCTGGAGTGGCTCCTGGCCTCGGTCATCGCCCGCAGCGGCCTGCGCCG
+CCTGGCGCGCCCCGCCGCCGATCCGGCCCGCAGCCTGCAACGCAGCGAGATCCTTCTGCA
+CCTCTCGGCCCTGACCGTCTTCTTCCTGTTCATGGTCAGCTACGACCTCAAGGCCGGGCT
+CATCGCCACCCCCCTGCTGGCCGCCTCGGAGACCCTCTCCGGCCTGGCCGCGCTTTTCTA
+CTACGCCCTTCTGCTCATCCCGGTCTGGGGCCACTGCCACCGCCTGGAGCGCGCCGCCGG
+CCGCGCCCTGGCCCTGGACCGCCGGCGCTACATCCTGGAACAGGCCCGCTTCGTGGCCCC
+GGTGGCCTTCCCCTGGTTTCTGGTCTCCGCCCTGCGCGACCTCTTGACCCTGGCCTGGCC
+CGGTCTCACCGCCTGGCTGGAGACCCCGGCCGGCGACCTGGCCTTTCTGGGCTTCTTCCT
+CCTGGTCATCTCCTGGCTCTTTCCGCCCCTGGTGCGATCCTGGTGGGGCTGCCCGCCGCT
+CCCCCCCGGCCGGGCGCGGGAGATCTGCCAGATGGTCCTCAAGGTGGCCCGGGTGCGGGT
+GGGGGGCATCCTCTCCTGGGACGTGCTCCAGGGACGCCTGGTCACCGCCGGCATCCTGGG
+GCTGTTTCCCCGCTTCCGCTACCTGCTGCTCACGCCTGCGCTTCTGGAGGCGCTCTCGCC
+CACCGAGCTGGCCGGGGTGGTGGCCCACGAGGCGGGGCACGTGCGCCTCAAGCACATACC
+CGCCTACCTCATGTTCTTCATGGCCTTCTTCCTGCTGGCCTACGCCCTGGCCGAGCCCCT
+GGACATCCTGCTCCGCCTGGCGCTGCTGACCCTGGCCCAGAGCGACTGGGGCGCCGGCCT
+GCTCAACTCGCCCGATGCCGGCTCCACCTTGAGCATCACTTTCGCCCTGCCGCTGTTGGC
+GCTCATGATCGTCTACCTGCGCTTTGTCATGGGCTTTTTCATGCGCCACTTCGAGCGCCA
+GGCCGACCTTTTCGCCCTGAACCTCATGGGCGAGGCCGCGCCTTTGGTGGGCGCCCTGGA
+GAAGCTGGCCCTGATGTCGGGCCAGACCCGCGACCTGCCCTCCTGGCACCACTTCTCCGT
+GGCCCAGCGGGTGAGCCACCTCCTCACCGCCCAGGCCAACCCCCCCGCCTGGCTGCACCG
+CCAGGGACGCCTCATCAAGAAGGCGCTTGCGGTCTACCTGGCCGGCATGGTCCTGGTGCT
+GGGACTGGGCTGGGGCATGGCCGGGCTGGACTGGAGCCGCCAGGTCAACCAAGAGCTCGC
+CCTGGAGCTGGTCCGCCACCAACTGGCCCAGCACCCGGACGACCCCCGCCTGCGCTTCCA
+GGCCGGTATGCTCTGCTACCAACTGGGCCGGGAGGACCGCGCCCTGAGCCACTTCCGCCG
+GGCCTTTCTGGCCGCGCCCGACAACCCTGAGCTGCTCAACGCCATGGCCTGGATCTTCGC
+CACCAGCCAGGACCCACGCCGCCGCCGTCCCCAGGTGGCCCTGGTCCTGGCCCGCCGGGC
+CGTGAGCCTGTCGCCTCTGCCCCACATCTGGGACACCCTGGCCGAGGCCTACTTCGCCGC
+CGGCCAGCCGGTCAAGGCCCTGGCCGCGGCGCGGGCCGCCCTGGAGGCCGGGCCCAAGGC
+CCGCCTGGACTACTACCGCGCCCAACTGGAGCGCTTCAAGCGCGCGGTGGAGGATCTGAA
+GAAGAAGGGTCCCGCCGGCCGGCGTCCCCGTCCTGCGGCTCCGGCGCCTGGTGGTAGGCA
+GGGTTGAAGGCGGTGGTGAACAGCCTCCCCAGGATGTAGAGCAGCCCCGCCCCGCCCACC
+TGTAGGCAAAGGGCCTCCACGAAAGAGAACCACACCCAGGGCAGCACGAAAAGCGCCAGC
+ATGAAGAGGATCAAAAGCGGCGCCGCGAGCTTCCAGTAGCGCCGCAGGAAGGCGTCGCCC
+CGCTGCCGGCGGTCCAGGAGGGGGGAAGGGACGGTTGGTTCCACGGGCGCGCCTCCTCAG
+ATGGTAAAGCCCAGCCGGGCCGGGTCCCAGTCCAGGCCCGCCAGCCAGGGCGAGTCGCTC
+TCTTGGATGCGCCGGGCCGCCTCCAGGAGCCACTCCGGCCGGCGGCCTCCTTCCCAGCCC
+GGCATGCCCCCCCGCCACACGTAGTCCACCAGGGCCAGGAAGCCCGTGCGATGGAAGCGG
+TACTGGCCGATGGCGAACTCCCCGCCCCCGGCCCGGGCCTCGAGCACCACTTCCCGGCGC
+CGGCCGAAACTCTCCGCCTCCTGCTCCACCACCTCCCGCGGGGCCGCACCACGGGTGCGC
+TGGCGGAACTGGTGCGGGTCGCGGGGAAAGGGCCAGCGGGCGTACAGGGCCCCGATGAAA
+CCCTCCAGCCGGCGGCCGGCGATGGCCCCGTGCAGATCGCCTCGTGAGGCGGGGTCCGGA
+ATCTCGAACCCCGTCCAGGAGCCTTGCCAGTCCCGCTCCGGCGGGGCCTGCGCCAGCCGT
+ACCAGGGCGTCGCAGAACTCTGGGGCAAAGAAAAAGAGTTCCTCCAAAAGCAGCATGGGG
+GTCTCGATGTGGAAAAAGCCGAAGGCCACCACTCCGTGGCTGCTGGAATGGAAGGCAAGC
+GGTCTCTTATACACATCTCCGAGCCCACGAGACTCCTGAGCATCTCGTATGCCGTCTTCT
+GCTTGAAAAAAAAAACAG
+>NODE_22_length_2891_cov_11.4392_ID_43
+GTGGCGGGGGGCGCGCCAAAAGCAAAGCGGGGCCCCGGTGTTGGGGCCCCACCGGTGGTT
+GCGAGGGTATGGCAGGCTAGCGGTTGGCCTTGCGCAGGCCCAGGGCGTCCAGGGCCACGA
+TCCACTTGCAGATGTTGGCGCTGCCCTCCACCATGAAGTAGGTGGGGGCGTCGCGGTAGA
+AGCGGGCCACGGGGTACTCGGTGGAGTAGCCATAGGCGCCCAGTATGCGAAGCGCCTGCT
+GGGCGCAGAAGTTGGCCACCTCGCCGGCCTTCCACTTGGCCATGGCCACTTCCAGGGTGT
+TGCCCAGGTTGCCGGCGTCCTTCTGGCAGGCGGCCTTGTAGACCAGAAGCCGGGCGGCCT
+CGACCTCGATGGCCATCTGGGCGATCTGGTCCTGGATCATCTGCTGCTTGGCGATGGGCT
+TGCCGAACTGCTCGCGCTCGTTGGCGTACTTGATGGACTCGTCCAGGCAGGCCTGGGCCA
+GCCCCACCCCGCCGGCGGCGGCCGAGAGCCGGGTCTGGTTGAGGGAGGAGAAGACGATCT
+TGGCGCCGTCGCCGGGCTTGCCCAGGATGTTTTCCTTGGGGACCTTCACGTTGTCCAGGT
+AGATCTCGCCGGTGGGCGAGGAATGGCTGCCCAGCTTGTCCAGGCGGGTGACGCTGATGC
+CCTCGGGGCGGGAGCCGTCCTCGTTCTTGAGGTCCAGCACGAAGGCGGAAAGCCCCTTGC
+CCCGGGCCTCACGGTCGGTGTAGGCGTAGTAGATGATGCAGTTGGCGATGTCGGCGTTGC
+TGATCCAGGTCTTGGAGCCGTTGAGCAGCCAGTAGTCGCCCTTGTCCACGGCGGTGGACT
+TCATGCCCATGACGTCGCTGCCGGCGTTGGGCTCGGTGATGCCGAAGCCGCCCAGCCACT
+CGCCCGAGACCAGCTTGGGGATGTACTTCTTCTTCACCTCGTCGTGCAGGCTGTAGCGGT
+AGATGGTGAAGGCGCAGCCCAGCTCCAGCATGTTGATCTGCACCCGCAAGGAGGAGCTGG
+CGCGGGCGATCTCCTCGGTAAGGATCATGGCGGCCAGCCAACCCATCTCGTTGCCGCCGT
+ACTCCTCGGGGATGACGGTGCCGAAGAAGCCCAACTCGCCCATGGGCTTGATCACTTCCT
+CATGAGGCAGATAGTGCTCCTCATCCCACTTGTCGGCATAGGGGGCGATCTGCTCCTTGG
+CGAAGTCGGCCGCCATCTCCCTTAGCATCTTTAGTTCTTCGCTGAGTTCGAAGTCCATTT
+TTTCTCCCTCGAAAAAGAGACCGTGGTTTATGGGGAGCGCCCAAGTCTTGGTGTGGGTTT
+AACCCAAAGCGAGGGATTTGGCAACCACCAAGCGCTGTATCTGGTTGGTGCCGTCGAATA
+TCTGGATGGCCTTGGCGTCCAGGTAGAGACGTCCGGCCAGGCAGTCCGGGCGCATGAGGT
+CCATTCCCAGGATGCGGCTGGCCAGTTCTCCGGTCTCCATGCCGGTGTCGGCGGCGTAGC
+ACTTGGACATGGAGACGAAGGCGTCCACCTGCTGCGGCGGGGTGCGGGGGTCGTCCACCA
+TGCGGCAGACCCGGTAGATCAAGGAGCGGCAGGCCTCGATGCGCATCTTCATGTCGGCCA
+GGGCGAAATCCCGCGACTGCCGGTCGGCGGGGTTCAGCCGCTCGGCGTTTGCCTTGACAT
+AGGCCAAGGTCTGGTCGAAGAGCCCCTGGGCGGTGCCCAGGGCCATGGCCGCGGCGCCCC
+ACACCCGCATGGGGTTGCAGACCCGGGTGAGCACCTGCCAGCCCTCGCCCTCGCCCCGCA
+GCCGGTTGGCCACCGGCACCGGCACATCCTTCATATACATGTTGGTGGTCACCGAGCCGT
+GCAGGCCCATCTTCTTCTCCGGGGGGCCGAAGCCGAGCCCCGGGGCGTCGTGGGGGATCA
+AAAGCGCACTGATGCCGCCGGCCTTGGGAGCGGGTCCGGTGCGCACGAAGGTAAGGTAGT
+AGCGGGCGTTGGGGCCCAGGGTGATGAAGGTCTTGGTGCCGTTCACCACATAGTGGTCCC
+CTTGGCGCTCGGCCCGGGTCTGGAGGTTGAAGGCCTCGGAGCCGTAGTCCGGCTCTGTGA
+GGCAAAAGGCCAGGCACTGATCGCCGGCCTGGACCAACTCGCCGAACAAACGTTCCTTCT
+GTTCCTCGCTGCCGGTCAGGGCGATGGTGCGCAAGACCGCGTTGGAGGGAAAGACCAAAA
+GCGCGGCGCTGGGGCTCACCCGGGCGATGTTCTCCACCATCAGCGCCAGGCGGGTGGCGT
+CGGCGCCCTGGCCGCCGTAGCTGCGGGGCACGGCCAAGGTGAAAAGCCCGGCCCGGGCGA
+ATATCTCCCGGGCCTGTTGGGGGAATCGGCTTTGACTCTCGATCTCCAGTGCAAGCGGCG
+CCAGCTGGGTCTCCACTACCTGCTGGATGTGTCGTAGGAAGTCTTGCTGGTCCTGGTCAA
+GGTGCAAATTTCACCTCCTGCCGGGATGGGTTCGACGGGGGATCTGGGCAGTTATAGCCG
+ATTGCGCCTTTGTGAACAACCAAAAAGCATACTGCCGCCCTGGGGCGGGAATCTAACAAA
+AAAAATCAAGGCTGCCCACGCCGGATTGGCGGCGGGAGCCTCAAGCGGCACTGATCCTGG
+CGGTGACCGAGGCGCCCAGGGCGGAGAGCGCCTGCCAGTCGCCCTCCACCCTGCCCAGGG
+GGTAGACCTGGGAGGCGGCCACCGGCTCGGGTCCGGAGGAGGCCGGGGTGGGGCCGAAGA
+AGATGCAAAACGCGTTACCGGGCTCCCAGTAGGCCAGATCGCCCACCGACATCACGGTCT
+GGGTCTCTCCCTCGAAGCTGCCCAGGGGTTCGCCCAAATCGCCGTAGTACTCCTCGCCCC
+AACGGCTGAGC
+>NODE_25_length_2759_cov_91.0869_ID_49
+CGCCCGCGTCCTCGGCCGCTCCCCCTGTCGCCCCCCTTGGCCCCCTTGGCCTTCCTAGCG
+GGGGATGAAGCTGGGGCCGCCCTGGCTCTCCTCCAGCTTGGAGCCCACCTCCTCGCCGCA
+GACCGCGCAGAAATAGGCGTACTTGTCGCCCTCGGGCAGCACCAGAAGCAGTTTCTTGCG
+CACCGGCTGGGCCTTGCCGCAACGGGGACACAGAAGCGACTGGGCCTCTATGCCGGCGCC
+AGCGGAAGAATCACCATACATCATGTCCTAAGCCCCAACTCCTCGATGAGCCGGTCCAGG
+TAGTCCAGGAGGAAGTCGCGCTGGGCGCTGGAGGCATAGGCGGTGCAGTTGCAGCGCAGG
+CTCTCCTGGGCCCGCACCAGAAGCTCCAGCCGCAGGCAGCCCTCCTCCACCACCACCGCC
+ACCCGATGCGGTCCGCAACTCTGGCGGTGCTCCTGCTGCAAGGGCAGCAGCAGGTCCTCG
+GGCAGCTCCAGCCAGTAGACCCCGCTGAGCCCCGAAGGGGTCAGGGTCTGGTCCAGGTGT
+TCGCTGAGCCGGTCCACGTCCGGCGAAGACAACTCGTCGATCACGATGGAGCGCATATCC
+TCTCGTTTCCCCTCTGGCGGGTGCCCTCAGCTCTCCCCCTGCCCGCCCTCCGCAGCGGAG
+CGGTCCAGGCGGGCCCCCACCCGGGCGGCGTCGATCACGGCAAACAGCCAGATGCCAAGC
+CCCGCCGTGCCCAGGCCCCACAGCCAGCCGGTGCCCTGGCGGGCCAGTTGCGCCCGCAGG
+GCCTGCCATTTGTCGGCCGACTGGGCGGCGGCCTCGCCCAGGGCGCTCATGGCGTGGCTC
+ACCTGGTAGACGGTGAGGAACAGAAAGCTCATGAAGAACAGGCTCATGAGGCAGATCAAG
+AGCGCGCCCTTGCCCAGCTGGCGGTTTATGAGCTGGCCCAGCCCGGGCAGTACCAGCCCC
+GATAAAAGCGGCGCAGTTATGCGTTTGGGAAGGCTCATGCCTCCTCCCGGCCGTAGAGTT
+CCAAATACTCCCGGGCGATCTGCATGGTGAGCTCGTCCAGGGGACGCATCTCGCCCTGGA
+TCAACACCGGGATGCCTTCTTTATAAAGATAGTCCAGGGCCTGGCGGATGCCCAAGAGCG
+ACCAGACCTCAAGCCCGCTCTCCTGGCGGAAGCTCTCCATGGCGTCGGGGCCGCGCACCC
+CCTCGCGCACCCGGCCCTGGGCGTCGTAGACCGCCTGGGTCTGCTCGCGGTCCACCGCCA
+GCACCACGCCCAGAAGCTCCATGGGGCGCTCCAGGCGGGGCTTGAGCCAGGAAAGCTTCT
+TCAAGAGCTCCAGCTTGGTGCTCATGGAGGTGCCCACGTCGTCGATGATGAGCACCTTGC
+CCCCCTGGAGGGCGGCGCCGGTGACGAAGAGGTAGCCGTGGCCGGTGGCCTCGCCGTGGG
+TCTTGGCCTCCTTGCGGTCGTAGTCGTAGGCCACCTCCTTGCCGTGCAGCTCGTAGAGGG
+CGATGGCGGTGGCCTGGGCAATGGCCGAGCCCTTGTAGGAGGGCCCCACGATGCAGTCCA
+GGTCCTGGTCCAGGCCATGGTGGTGGATCCACAGGCTGAAGCAGCGCCCCAGTTCCAGGG
+CCAGTCGCCCGGTGCGGAAGACGCCCAGGTTCACAAAATAGGGGGTGGGGCGGCCGTCTT
+TGAGGCGCAGCCCCTCCTGGAAGAACAAGCCGCCGCTCTCGGCCAGCAGGCGGGCCAGGG
+TCTTTTGATACTCCTCCATGACCACTTCCCTTTCCTCGCGTCTGGCGCACCGCCCGGCGC
+CCCTTGGGGCCCGGCGCGGTGAACCGTCTTGGCTGATTTGGTGAGGATCGCACCGCCAAT
+TTAGTCCAGCCAGCCGGGGTTGTGCAAGCTTTCTTGTGGGATTTCGGGGGGTGCCGGCGG
+GTACCAGTATCGTTACCCGTCGGTTCCAGGTTTTGAACCGTTATTTTTGTTTTTATTTCA
+CGATATTAACGCCACAACGCCCTTGGGGGCGCCAGAAGGCGGTTCAAATTTTTGAACCGA
+TCCCTCCAGAATCAGATCTCGGCCCGATATTGGTCTTCACATATATCATCTCGAAATAAC
+ATACAAAACAATGAAAATTGTGCCTGCGACCCAAGGTTGGCACCCTGCTTGCTTGTATGT
+AGGGCATCCCTAATCCCCTTTCTCCCTTTCTTAGAGGGCGCCAAGCTAAAAAAGCTTGGC
+GCTTTCTATTTGGGGAGACGCCGGCGCCTCCAGGCTGGCAAGCACGCCGGGAGCTCCCGC
+CACCAGTCCGGCCCTGGAGCACCCCGGCGCTTTCTATTTGGGGGGAACTGCGACCCACCT
+TGGCGTGCAACCCACCCGCCTCCACGCAGACAGGGACGCCCAGCGGGGCGCCCCTTGTCG
+ACAATGCAAAACAAACCAGGAAAGGGGATTACTCTTCTTTCTTCTCGTCCTCCTGCGGTG
+CCTCCTCGGCGGGGGAGGAGTCCTGCTGCTCCTCCTTCTCCATGGCGGCCAGCTTGGCCT
+TGAGTTCCTCCACCTCCCGCTTGTACTTGTCCACGTCCTGTTCCTCGGGGGTGAAGGGCT
+CGCGGGCGGACTCGTCCTCGGCCTGGCGCTTGTCCTTCATCTCCTCCAGGCCCAGGTAGG
+CGGCCAGGACGCCGCCCAGGATGAGGATGGGAGGGATGGCGCCCTTGAGCAGCCAGATGA
+ACTCGTCCCACCATCCTATGAGTCCGATGATTCCCAGAATCAGCGCGGCCAGTCCTCCA
+>NODE_29_length_2081_cov_1172.16_ID_57
+ACACTAGATCGCTCGTCGGCAGCGTCAGATGTGTATAAGAGACAGGGGGTGGCGAGTTGC
+ATGGGCGGATCAGTCCGGTTGAAGGATGGGGCGGAAAGTGCCGCGAGCGGGGCCGCGCGT
+CAAGAACCGCTATCCCCGTTTATTGGGAGACCGCGGCTTCCTCCCGGACGACGGCGAGAA
+ATCCCTCCGCCAGCCGGGACAGCGACTGCGAGCGCGAATGGACGGCGCGCGGGCTGACCT
+CGACGCGCGGCCGGAAGGGCCGGCGCACCAGGGTCGGGAACCGCTCGGCTTGCACCCAGG
+GGTCGACCAGGCCGATGCCGGCGCCCGCCTCGACCAGCATGTAGACGGTCATCGTGTGGT
+TGCAGGCGATGGCGAAATCCCGCTCGACCCCCTGCTTGCGGAAGGCCTCCTCGATGCGCG
+GGGCGATGGAGTTGCGGATGTTGGTGATCAGCGGGAAGGCGCTGATGTCGCGCGGGCCCA
+ATGCCGGTTGGGCCGCCAGCGGATGATCGGGCGGCAGGACGCAGACCATCTCCGAGGCGG
+CCAGGCGCTCGAACTGTAGCAGCGGGTTTTCCGACGGGCCATGGATGAACCCCAGGTCGA
+TCTGGCCGGCCGAGGCCAGTTCGAGGGTCCGTTGCGTATGCGTGACCTCGAGAAGGATCC
+GCACGCCCGGGCGCTCCTCGCGGAACCGTTTGAGGGCATTGGCCAGGAAGGCGTAGGTCA
+GGGTCGGCGTGCTGGCGATGGACAGCACCCCCGAGCGGTTGCCGCGCAGGTCGTTGGCGA
+ATTTCTGGATGGCGCTCAGCTTGTCGAACAGGCCCTCCACCTCGGTATAGAGGTCGAGCG
+TGGTCTAGGTGTCGTTGTACGTGGGATCCCCGGGTACCGAGCTCGAATTCGCCCTATAGT
+GAGTCGTATTACAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGGC
+GTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAGCGAA
+GAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCTGAATGGCGAATGGCGCCTGA
+TGCGGTATTTTCTCCTTACGCATCTGTGCGGTATTTCACACCGCATATGGTGCACTCTCA
+GTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGCCCCGACACCCGCCAACACCCGCTG
+ACGCGAACCCCTTGCGGCCGCATCGAATATAACTTCGTATAATGTATGCTATACGAAGTT
+ATTAGCGATGAGCTCGGACTTCCATTGTTCATTCCACGGACAAAAACAGAGAAAGGAAAC
+GACAGAGGCCAAAAAGCTCGCTTTCAGCACCTGTCGTTTCCTTTCTTTTCAGAGGGTATT
+TTAAATAAAAACATTAAGTTATGACGAAGAAGAACGGAAACGCCTTAAACCGGAAAATTT
+TCATAAATAGCGAAAACCCGCGAGGTCGCCGCCCCGTAACCTGTCGGATCACCGGAAAGG
+ACCCGTAAAGTGATAATGATTATCATCTACATATCACAACGTGCGTGGAGGCCATCAAAC
+CACGTCAAATAATCAATTATGACGCAGGTATCGTATTAATTGATCTGCATCAACTTAACG
+TAAAAGCAACTTCAGACAATACAAATCAGCGACACTGAATACGGGGCAACCTCATGTCCG
+AGCTCGCGAGCTCGTCGACAGCGACACACTTGCATCGGATGCAGCCCGGTTAACGTGCCG
+GCACGGCCTGGGTAACCAGGTATTTTGTCCACATAACCGTGCGCAAAATGTTGTGGATAA
+GCAGGACACAGCAGCAATCCACAGCAGGCATACAACCGCACACCGAGGTTACTCCGTTCT
+ACAGGTTACGACGACATGTCAATACTTGCCCTTGACAGGCATTGATGGAATCGTAGTCTC
+ACGCTGATAGTCTGATCGACAATACAAGTGGGACCGTGGTCCCAGACCGATAATCAGACC
+GACAACACGAGTGGGATCGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGGAC
+CGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGG
+>NODE_2_length_41759_cov_213.726_ID_3
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+CACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGTTGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCAGTCAGAAGAAGACATTGAA
+ATCACAACCTGGATTGCAAAAAAATATGGTTGCAAGTTCGATGTGGTTGATCTCCAAAAG
+GAATATTGGGATACGGTAGTAAAATATACTATTGAAAGTGTAAAAGCCGGATTGACGCCG
+AATCCTGACATTATGTGTAATCTCCTGATTAAATTCGGGGCTTTCAACGATCGTTTTGGG
+AAAGACTTTGACCGGATTTCTACCGGTCATTATGCAACACGTTATAACACGGATGAAGGC
+GTTTTTCTTTCTACCGCAGCCGACCGCGTAAAAGACCAGACATACTTCCTGGGACAAATT
+ACCCCTGAACAGCTGGCAAAAACCATGTTCCCTATCGGCCATCTGCAAAAAAAAGAAGTC
+CGCAAAATCGCTTCGGATATGAAACTTCCAAGCGCACACCGCCCTGACAGTCAGGGAATT
+TGTTTTCTTGGGAAAATCAACTACACCGACTTTATCAAGAAATACGCAGGCGAAAAACCG
+GGAGAGATAATTGAGCTGGAAACAGGAAAAGTGCTGGGAACGCACAAAGGTTTTTGGTTT
+CACACGATTGGTCAGCGACGTGGACTGCGACTTGGTGGCGGCCCTTGGTTTGTCGTCAAA
+AAAGACATTGAAAAGAATATTGTCTACGTCTCAAATGGCTATGACCCCATCGCTCAATAC
+GATGACAAAATCTGGCTTGAAGATCTCCACTTTTTGAATAAAGTCCACGATTACAGCAAA
+CTCAACGAAATCAAATTCAAAATCAGGCATCAGCCTGAATTTAATTCAGGTAAGCTGGTT
+CGTGATGAAAAAGGGATAAGAATTGTTTCGGAAAATAAAATTTCGGGTATTGCTCCCGGC
+CAATTTGCTGTAGTTTACGATGAGGAAGAAAGAACCTGTATCGCCAGCAGTGTGATTGCA
+GAGAATCCTGAAATTGCTGTTTAACAGAAACATCAGACCACACAAAAATTTCTTCATTTC
+ACCGAAGGAAAAACCTACTTTGTTTTTAAAACAGTAAGTTTTTATAACTTAGCTTGTCTA
+AAAATTCTCGAGAACTATGAATCCTCTCCTTTTGTTCATCCTGATTGTTTCAGGTGGCCT
+TTACCTGGCCGGCCATTATCTTCATAAACCAATTCTGAAGTACATCTTCAAACCGTTTAC
+TACGTTCATAATTCTGTTTTTTGCTTTTATGCAATTACCGGATGTATCTGTGCAATACAA
+AGATTACATTCTTATCGGTTTATTGATTTCCCTTATCGGGGATATTTTTCTGCTGTGGCC
+GGAAAAAAGATTTATCCACGGACTGGGAGCATTTCTTCTGGCCCACGTCCTCTTCATCCT
+GGCAATGGTTTCCGACTTCGGCCCTTACTACAATTGGCAATATCTCATTCCCATTGCTCT
+GTACATGGTTATTTTCCTGTGGATTATTTTACCCAAATCAGGTAAATTTGTTATTCCGAT
+AATCGTTTATGCCCTGGTCCTGATGGTATTTTTCTGGCAGGCAGCTGGACGAGCCATTTA
+TCTGGCAGAAAGCAGCAGTATGCAAGCCATGTTCGGAGCCACGCTGTTTGTAGCCTCAGA
+TTCCATTCTGGCTTACAACAAGTTTGTTAAAAATTACAAATGGGCGGAATTTTTCATCAT
+CATTACTTACTGGGCAGCACTGTATTTTATAGCTTTGTCCGTTTAATTGAATATCATGGA
+TTGGATCATCGTAATCATACTGGCAATCCTGCTGGTAGCCTTTATAATTTTGTTTCTTTT
+AATACAGAAAGGATTCAGAAATCCCGTATCAGAACATACGATTCCTGAAGATTTACCTTT
+TGACGTTCAGGAAGTTGAATATCCCACTAAAAATGGGAAAACGATTTATGGATGGTGGAT
+ACCGGCAGATCCCAAAGCCGCTACTGTAGTTTTTGTCCATGGCTGGGGAAGAAACGCGCA
+GCGCATGATGCCTTATCTCCGGAAATTCTGTTGCGGAAAGTTCAACCTCCTGGCTTTTGA
+TGCCCGTGGACATGGTAACAGTGATCACGACGGCTTTTCCAACATGCTGCAATTTTCAGA
+AGATATCATTGCTTCGATGAACTTTATAGAACAAGAGCATAAAGCAGAAAATAACATGTT
+TTACCTGATTGGTTTATCCATCGGCGGTGCCGCTTCAATTTACGCAGCAGGTCACGATCC
+CCGGGTGAAAAAAGTGCTGACCGTAGGTGCTTTTGCTCATCCGGCATCCGTTATCACAAA
+ACAAATCAAAGACCGTCATATACCTTACTTTCCCATGATTTGGTTCCTCTATCGTTACAT
+GAAATACGTTAAGAATCTTGATGTGGATGCTATCGCCCCGGAAAAACATATTGCAAAGGC
+CCAGGCGCACTTTTTGCTGGTGCATGGGGAAATTGACCAAACCGTTCCCGTAGAGCAGGG
+AAAACGGCTGAAAAAAGCAGCCGGAGACAAAGCTGACCTGTGGCTCATGCCTGAAAGAGG
+CCATTCTGACTGCCATCTCGAACACGGATTCTGGGAAAAGCTCATGGAATTTTTTGAAGC
+TCCCAAAACAAAAGTTCAAAAATCTTAATTTCGCCACAAATCATTGCATATGAAAAAATT
+CCACTTGTTGTTGCTTTCTTTGCTCAGCGGTTTATTGCTGGCAGCAGCCTGGCCGTTACA
+TGGGTTTACACCCCTTATATTTATTGCTCTGGTGCCCTTGTTTTTCGTACAACAGCAAAT
+GGGCGATACCGGGAAAAGGGGAATGCTCCTCTATGCCTGGCTGACTTTTTTGGTGTGGAA
+CGGACTGACAACCTGGTGGATATGGAATGCTACGCCTGTAGGAGCTATTGTTGCTATCGT
+TCTCGATTCGTTGTTTCTGGCCATTGTCTTCCAGGTGTTTCATCTTTCGAAAAAATGGCT
+TTTCAACAACAAACAGGGATTCTTCATTTTAATTTTTTACTGGATAGCCTGGGAACATTT
+CAACGCAAACTGGGACCTGTCCTGGCCCTGGCTCACGCTGGGAAATGTCTTCGCCAGTAA
+ACATCTCTGGATTCAGTGGTACGAATACACCGGCGTTCTGGGTGGCAGTTTGTGGATTCT
+AAGCGTCAATATTCTTATCTACAACATCATCAAAAGCTTTTTGGAAAAAAGAAAACAAAG
+AGCCCTTTACACGACCATACTTACAGTACTTTTCATTGCTGTTCCCATCATCATTTCCCT
+GAACATTTATCATCATTATAAAGAAACCAAAAATCCTGTAAACGTGGTGGTCGTGCAACC
+AAATACCGACCCATACACCGAAGAATTCAATCTGCCGCCATCCGCACTGATAAAGCGAAA
+CCTGAAACTGGCAGAACAAAAAGTAACCGACAGCACAGATTATGTGGTTTTCCCGGAATC
+CACCATCCAGGAGCAGATTTGGGAAGGAAGTCTGAACCGCTCCCAAAGCATCAAAACACT
+CAGGAATTATGTCATGGAGCATCCGAATCTCTCTATGGTTATCGGCGCTTCAACCTTTCG
+CTGGCTGAAACCGGGCGAGCACCGGACCAACGCTGCGCGTTTTTACAAAAAAGGACTTTA
+CTATTACGCCTACAACACGGCATTTTTTATTGACCATTCACCTTACATCCAGGTGCATCA
+CAAATCGAAACTTGTTCCCGGTGTTGAAAAGATGCCTTCCTGGCCCATTCTGAAACCGCT
+TGAACATCTGGCACTGAACCTGGGTGGAACCGTTGGAACCCTGAAAGAAGATGACCACGT
+ATCTTTATTTACCAATGACAGTTCAGGAACGAAAATTGCTCCGATGATTTGCTACGAGTC
+CGTTTACGGAGACTATGTCCGTCAATATGTCGCGCATGGAGCTGAGCTGATTTTCGTTAT
+CACGAACGATGGCTGGTGGGGCAACACGCCGGGATACAGACAACATTTTTCATTTGCCAT
+TTTGCGTTCCATTGAAACACGTCGTGATGTAGCACAGTCTTCCACCACAGGATATTCAGG
+TTTTGTAAACCAGCGCGGAGATGTGCTGCAAAGAACAAAATATGATGAAAAGGCTGCACT
+GAGTCAGACGCTGAACCTGAACGACAAACTAACTTATTTTATGAAAAAGGGAGATTACCT
+GGCCCATCTGGCAGGTTTCTTCAGTATCCTGATTTTGTTGGCTGCCATAGTTCAGGGATT
+TTTGAAAAAGAGGAATTTACCGCACTAAATACTGACTATGAAAACATTTCTGGACCTGGT
+AAATCAACGGCAAAGCGACCGGAAATACATCGACAAACCCGTCGAAAAGGAAAAACTGAT
+GCGTTGTCTTGAAGCGGCACGTCTGGCCCCTTCAGCCAGCAATTCACAGCCGTGGACTTT
+TGTGGTGGTTAACCAGCCGGAACTATGTCAGGATGTGGGAAAGGCAGCCATGGGTCCGCT
+GTACAGCTTCAATAAATTTGCATCACAAGCTCCTGTCATTCTCGCAATTATCATGGAAAA
+ACCCAAGGTTATTACCGAAGTTGGCGGTCGCATCAAGAAAAAAGAATATCCGCTCATCGA
+CGTAGGAATTACAGCAGAACACTTTTGTTTGCAGGCAGCAGAAGAAGGCCTGGGGAGTTG
+CATGCTGGGATGGTTTGATGAAAAGAAGGTGAAAGAACTATTACATGTTCCGGAAGAGAA
+AAGCATCCCGTTGCTTATCACAGTCGGATACACCCCTGAAAATTACAAACACCGAAAAAA
+AATACGCAAACCTATCGATTCGGCAGTAAAATTCAATACTTATGGCTAAACAAAAAACCC
+AAGAGAAAATCTGGTATGCAATCTATGTTAAATCACGCGCAGAAAAGAAGGTTGCAATAG
+AACTGGAAGCGGAAGGCATAGATTTCTATTTACCGCTTGAAAAGCGCTTAAAACAATGGA
+GCGACAGGAAAAAATGGGTAGAAGAACCACTGTTTCGCTCCTATATTTTCGTCCATATTT
+CCCACAAAGACTATTACCGGGCGCTGGTTCAAAACACGGTAAAATACGTGACCTTTGAAG
+GGAAAGCCGTACCTGTACCACCGGAACAAATCGAAGCTGTTAAAGTCTATCTCGAGGAAA
+AAGAACCCATTCAACCAAACGACGAGGACTGGGAAACCGGAAAAGAAGTGGAGGTCATAT
+CCGGAAAACTTACAGGGCTAAAAGGGGTACTGATGGAAGTTAAAGGCAGAAGCCGTGTCA
+AAGTGGAAATTGAAGTAGTAAGCAGCTCCATCATTTTACACATTCCTAAGAGCAAATTGC
+GGTTGTTGGAATAAAACTTAACATTTCCAAAATTTGTATCTTTGAAATTCGTTACTTGTT
+CAAACAACAACCACATGGGCGTTAATTTACTGGATATTATCCTGGCAGTTCCGCTGATAT
+TTTTTGGCTATCACGGCTACCGAAAAGGGCTCATTATAGAGGTTACCTCGCTGGCAGCTT
+TTATCCTCGGTCTGTATTTTGCCTTCTATTTTTCCAATTTTACGGCCGGAATCCTTAAAG
+AATATTTCACCATTCAAACCAAATACATGGCCGCCATCGCCTTTGTAGTAACGTTTATTG
+TGGTGCTGCTCATTGTGCTTGCCGTTGGAAAAATCGTGGAAAAATTCATTGATATTCTTT
+TGCTTGGTTTCTTGAACAAACTGGCAGGAGGGTTGTTTGGCGTACTGAAAGGCGCGCTGT
+TTTTGAGCATTATCATATTCGTAATCAACTACTTCGATGCCAGTCATAGCATCATCAAAC
+AAAAAGCCAAAGACAATTCGGTTTTGTACAAGCCTGTAGAGTCCATCGCACCGGCACTCT
+ATTCCTGGTTGCATTTAAAGAATTTCGATTTCCATCTTCCCAGCGAAGAAAGTGTTATAA
+AAACCATCACGCATCGCGCTAACCCGGATTAAGGAAAAACAACAGACGGATAATCGCTAA
+CCATGACCGATGGAATATGAGAACCGTATTGTTTATTAATAGCCTGAATAAAGTAATTAG
+CAACAACGGCATTGCCTTGTGGGGTTAAATGAACGCCATCGAGTGAAAACAAATTCCCTG
+TAATAAACGCTGTAGTGAAATGTATTCCATCAACGGTTAATCCTCCATGTTCGATGCTTT
+TCATAATACTGTTAAAATCAACAAAGGCCAAATTATATTTCTTTGCAAGGCTCTTGATTT
+CTGCATTATAACTCGTTATGGCCGACTCTACTTTTGCAGTTTGAGCCTCTGTCAATACAT
+ATTGCGCCGGAACAGGTTTTTTTGTTCCCCAATAGGCAACTTCCAGTGAATCGGTAGGTA
+TATCGAGCATTACATATTCATCACTTTTTAATTGTCTGAATTGCAGGCTGGCAGGCACGG
+GCATGGAAGGATCGGAGATTACCATCGCGTTGGCGCCGAGCTTAAAGTTAATCCTGTAAC
+TAAGGCCCATTTGTTTCATAGCAGCATTTAACTGATCAACTTCTGTTTGAGTAGTAAAGG
+GGATGGCATTATAAGGTATCGTGTTAATATAGGGGATGGATGTAATATCCGGAATGCATT
+GGGGGTAAAATTATTTATATTGGGCTTACAGGAGGCCAGAAAAACCAGAAATACAAAAAA
+TAAAATTTTATAATATCGTCTCATGACCTTAATTTTATAAATAGATTAAAAGTGATAATT
+AATTCCGATACCGGGGACTACCGTATTGGTTTTATAATAACCGCTAACATTGGCCGGAGA
+TAATTCATAATAGGCCCCTGCCCGAACCATAAGCTTTTTAGAAACCTGGTACTGAGCCCC
+GATTCTGGGAATCCATTGATCTTTATATAACTTTGGGCTGGAATTATTGAGTAATTGCGG
+GTTGGTTGCAAAATGAAAGGATAAAGAATCATAAACACTCCACCTTACCCAATCCAGCTC
+TGCTGCAAGAAGTAACTTTTTTGTAGCCTGATAAGCAACACCAAAATCAAAGTTGGCAGG
+AAGTGGAAGGCTGGCACTAAAATGGTTCGACGGAGGTATTATACTGCTAAGGGAACCGGG
+GACAAAAAATGCTGCATTTCCATTTTTCACGTTCATCTTTATTTCGGAACGGTATGTTGC
+CCCTAACGACCACTGATCGGAAATTTTATAATGGACACCTACATTAAAACCAAAATTATG
+AGTCTTCCCATTTAAATTAAAACCGGAGTTCCCACTATAATTCAAAGCACTGTTCATTTT
+CACATTTCCCGTAGCGTAAACCAATCCGGCGCCAACACCGAATTTATTTCCCAAATTAAA
+GGATATAGTTGGCTGATAGAAAATGGCTTGAAGTGAAATGTTCTGAATCAACAGCTTTAA
+TGCCCAGTTGTCATCCCATTTCACTGAACTGCCATATGGTGTATAAATTGCCAGTCCGAC
+AGCAATATTTTTATTCAATTTTTCAGCTGCATAAAAATAAAATGGTGTTCCTATAGGATT
+ATTAGTCCTTGCCAGATAGTCACTTCCGTAACTCTCCTAAGACACATTGGAAAATATGGC
+ACTTCCTCCCAATTCAACACCAAACTTTCCTTCCATAAATGACAAAGCCCCCGGGTTATA
+AAACATCGAACTCGCCCCAAAACTGAGAGGGGCGCCAATTAACCCCATTCCTGTTTGTTT
+ATTTCCCTGAAGGCGTACCTGGTAGCCTCCGGCAAAAACGGCTGTAGATATAAATAAAAA
+CCCCACAACTAAAAAAATTGTTTTTTTCATGTGTATCTGGTTTTCTAAGTGTATAAATTA
+TCTCATATAAAATTTCAAACCACCCTTCATTAATAAAGAATAGTTCAAACCTTTCTTATA
+AATTGAATTTCAGGCACAACACCTTGCCCTTATACAAAATTAGATAAAAACAAACTCTTA
+AACGTTAAAGAATGTTAAATCTAATTATGATGGGCAACAGGTAATAATTATTAATCTCGT
+GAACGAAAAATCTTCACCATTCACACTCTGATTTTAATAGATAAACTCAGAAATCATAAC
+GGTCTATCTATCGACAGAAAAAAAGAAATTCCTTGATGGGTTTTTAAAGGCATAAAGGCC
+TCTAAAAATATCAAAAGGGACCCTGAAAAGAATCCCTTTGTTTTGACATTTTTGTCTGTC
+ACCAAAGTTTATCCCTGGCGAGTTGCTACCCAGTAAAGCTCGCTTCCGTTTAACTTAATA
+AATCAAAGGTAAGATAAAGAAAATGCTGAAGGATTTTTCTGTTAGCAAAATCACCAACTA
+TTTTGTCCACATGAACAACTCGCGTTAAAAAAACCAACTATTTTGTCCATTACGCCCTAT
+ATTGTCATATCCGCAGGCCCGGGCGATTACTTTGATCAGCTCATTTGTGGCGTCAAAAAA
+ATTGAACAATTGCTTTGCCGATGACTCGATGATAAGCCTGCTTCTTAACTTTTCTTTTTG
+GGTAGCCACGCCCACGGGGCAATTGTTGGTATGACAAGCACGCATTCCTAAACATCCAAT
+GGCCTGCAAAGCAGCATTTGAAACAGCAACTGCATCAGCGCCAAGCATGAGCGCTTTGGC
+AAAATCATCTGCAATTCGCAATCCTCCCGTGATAATTAACGAAACATTTTTTACGCCTGA
+CTTGTCGAGATATCTTCTGGCCCTTGCCAATGCAGGGATAACAGGCACATTAATATTATC
+CCTTAAAATAACGGGGGCCGCGCCTGTACCACCACTACGGCCATCAAGGATAATATAATC
+AACACCTGTTTCGAGGGCAAAATCAATATCTTCCTCAATATGGCTGGCTGCCATTTTAAA
+TCCGACCGGAACTCCGCCTGTAATTTCCCGGACATGGTTGGCCACCTTCCGGAAGTACCC
+CGCCTTCTTCGCTGCAAATACCTGTGCCGGCCATTTCCGCCCCTTTGGCTAGAGCTATTT
+TTTCCTCCTTTGAAAATGCACCAAAACTCATATCAGAAACAAATACCGGTTTCTCTAATA
+CCAAGGGCCTTTTTGCCCCAGGCACTATTACTACCTGAGTGTTAACCCGTGTATCATCAA
+ACAAAGGTTTTACGGCCAGTTGCGCCGGTAAAAATTGTATCATAATAATCATTTTACTAA
+AGTTTCGCACAATCTAAAAAGCCTAAAAACATTGAAAAAATGAGTTAAAAAAAGTAGCAT
+GATTGTTAGCTAATTTAATGAAAATCATTAAATTAGCAATGTTTTCCAAAACACAAACCA
+TGCTACAGCACAAAGATATAAATAAGTTGTCAGAGTTGAAAAACGGATTTACCCAAAGCT
+GGGTTGAACCGGATTTTATTTTTCGTTCTTTGAAATGTTTTTCATTTTCGAGCTTGAACA
+AGGGGCTGTCACCACTTAAAGCAAAAGGGTACAGTTTTGAATGGGTAATGAGCCTGTTGA
+TATCGCTACCATTTATGGGTATATCTTCAGTAAACAGGCTGGCCGGTGTGGTAGAGGCGA
+AAAAAGATGTTTTTTACCGTCTTAAGAACAATTCTTCAATTTCCTGGCGATACATCCAGT
+GGCTTTTTGCCTGCAAGTTCAATACCATTACTTCTGAAAGTACGGGTAACAATATCCAGC
+CCAGGTGTTTGATTTTTGATGACACGGTCATAGAAAAGACAGGCCGGTTCATTGAGAAAG
+TTTCCCGTGTGTGGGACCATGTTCAAAACCGCGGTGTGTTAGGGTTCAAACTCTTGGTAA
+TGGGCTATTGGGACGGGACTTCCTTTTTGCCGCTTGATTTCAGTATTCACAGGGAAGTGG
+GGAAGAACAAAGAATATCCCTACGGTTTACGGAAAAAGGATTACCGCAAACAGTTTAAGA
+AAAAAAGGTCATCCCAGACACACGGTTACGATCGCTCAAAGGAAGCCGGACAAAGCAAGA
+TCGACAACATGATAAAGATGTTCAAAAGGGCCCTTTCCCATGGGTTCAGCATTGATTATG
+TTTTAGTTGACAGTTGGTTTACCTGTGAGGCAATCATCCAAGCGGTTACGCAAGTCAAAA
+ACCAAACCGTCCATCTGATCGGCATGTATAAAATAGCCAGGACCTTATTTGAATATCAGG
+GCACCAAACAAACCTACAGCCAGATAAGAAATCGTCTTGGGCGGCCTACACGCTGCCGGA
+AGCTCAGGCTTTATTACCTACAGGCAACTGTTGGGTTCAAAGGCCATCAGCTCCAATTGT
+TTTTCACCAGGCAGGGCAAAAACGGCAAATGGAAAGTACTGTTGACCACAGACTGCTCGA
+TCGGTTTTATCCGTTTGGTTGAAATTTACCAGACACGCTGGACCATAGAAGTCTTCTTTA
+AGGAATCGAAACAGTTGCTGGGGCTGGGACATTGTCAGTCGAATGATTTTGATGCCCATA
+TTGCAGACTTAACCATTACCATGATCCAGCATATGCTTTTGACCTTAAGGTACCGCTACG
+ACACTTACGAGTCAAAAGGGGCACTTTTTGAGAACGTTAAAGAAACAATAGCCATACGAA
+AGCTCAATGAGCGGTTATGGGGGCTGTTTGTAGAACTCCTGCAGATACTGACTGATTTAT
+TTGAAATAGTAGATGCAATGGAATTACTTGAACATATTATCACAAACGGCCAAGCCCTTG
+AACGGTTAAAATTACTGTTTGACCTGGTGCCAGAAAATAACGAAGCAGCCTGACTGAAAA
+TGGAAATTTTAAAACATTGAAAAATAATAAAATACAAAAATTTACTCCTGTTAACCTGTT
+TTTTTACCGTGGGTTATGGAATGTGCGAAACATTAGTCATTTTAGTTTTGGATATTCAAA
+CAAATTCAATGAAAAATACTTATTTACATCCGTAAAGGATGCCTGAAATTTCAGCCCCGA
+TGATAAAGCAAGCTGTTCTATTTGTTCAGGCAAAAACTTATGTGAGTTCTCTGTATGGAT
+GGATTCCCCCTTAACAATAAAAATGTCATCCCGAAAGTGTTTACTTGTTATTCTCATGTC
+ATACAATGCTTTTAAATGCATTTCAACACGATTTTCATTTTGATTATAAAAAGCAAGATG
+CCCAAAATCTGATGTTTTGAAATTAGTACCGGACACATCATTTACCACATTCAGGATATT
+CTTGTTGAACTGCGCGGTAATCCCCTGTTTATCGTTATAGGCTTTATACAATATTTCAGG
+GCCTTTTACCCTGTCCAACCCCAACAAAAGCCTGTCTCCCGGGTTCATAATGTTTTTCAG
+GTTCCATAAAAAATCCGTTGCCTGATTACGGGTCATGTTGCCGAGCGTGCTTCCAAAAAA
+GCAAATAAGCCGCGGTGTTGCTCCGGGTAACAAATCAAGGTGCTTCAAGAAATCAGCAAG
+TAATCCATGAATCTTTAGCCCTTCATACCTGGATGATAATATTTCAGCCGATTTTATAAT
+GGCCGATTCACTCACATCCACGGGAATATATTTTACATTACTCATTTTCTGTTCAGGAAA
+ATTGTCAAAAAGAATGGATATTTTTGAACAATCACCGCTGCCCAGTTCGATGATTACCAG
+GGATTCGGGGTTACCTAAAATTTCCTTTGCATGGGCAGAAAGAATTGATTTTTCTGTTCT
+CGTGGGATAGTATTCCGGTAATTTGGTGATTTCTTCAAACAGAGCTGAGCCTTTTCTATC
+GTAAAAGAAACGGCTGGAAATATATTTTTGTTTTGCGGTTAATCCTGAGAAAATTTCATG
+GATTAAACTGCTGCGGGGTTCCTTTGACAGAAAATTTGTGATTTTAAAATTCGGTTTGAT
+AATAACAGGGGCTTCAGCCTGACTCATAATTTAAATTTTAAGTATGATTAATTTCGATTT
+GGATAATTTTCCGGTATTCCTGTTTCGACCGGGTTTGCCGGGTCAGCGCTCCACTCGAAC
+CAGCCACCATCGTAAACAGAAACTTTTGGCCAGCCCATGAGCCAGGCATTGAACCAGGCT
+TCACTGCCACGCCATCCGGTACCGCAATAAAAAGCCAGATGTTTGTCGGGTGTTATCCCG
+TTAGATTTCCAAATATCTTCAATTTCATGATATTCGCGGGTGGTGTGGTCGAAATTGCGG
+TAATTCTCCATGTGATAGGCGTCGCTGCCGCAATCGGCAAATATGGCGCCGGGGATGCGG
+CCTTTGGGTTCAATATAATTGTAACCACTTACTTCGCCAATGTATTCCGGCCAGCTTCTT
+ACACAAACCAGTTCGGCCCGGGACGATGCAAGCATTTCCTTAGCCTCCGGGGTGTCAACT
+GCCAGTTCAGGATGGGCGGGAATAGTTGCTCCAAAATCTGCAACCGGCTTTTTGGGCTCA
+TCTGCATAAGACACTTCATAACCGGCATCCAACCATGATTGGAATCCGCCATTCAGTACC
+CTGACATCTTTTACTCCGGCATACATCATAATTAATGCTATGCGAATGGCCCCAATATCG
+CCGGCAGCGCTTCCCGGAAATTCATCCGAATTATCAGGGAACATAAACTTGCCGTAAACG
+ATGACTGTGGTATCGACTGTTATGCCGTGTTGCTCAAAAGTCTGTTTCAGTTCTTCAGGC
+GAACGGCGGTTCCATGTTTCAGGGTCCTCGACAGCCAGCGTGTCCATGTCAATGGCACCG
+GGAATGTGGCCGGACAGGTAGGCATCCCGGTTCCGGTAATGTGCATGAACAATAACATAT
+TTGTCGTTTTCAAAATGTTGTGGTTTCCCACCGGAAATTAACTCATTTACCCAGGAGGCA
+GGGACCAGATTTTGAAAACGGAAAAGTTTCTCCATCGGCAACGTTGTATCAGGGACCCAT
+TCGTTAAGAAAGTTGAGATAGATACTCACCTTTTCAAACCCCGATTTTTTAAAACGATTT
+GCAACAAGGCGAAAGCCTTCGTCAGGGTATCCGTAAATAACAATTTCGTTTTCCGGGAGG
+ATTTTCTTCCGGTGTACCATTTCAATCCAATCTACATACTTTGTCCAGGCAAAAGGCAGA
+CTTTTTGCCCCCCGGATGTGCCCTCCGCGGGATTCACCCCGGGATGCCCAGCCATTGTAT
+GCATCCACAGGGCGGATGTCTATTAATTGAACGTCCTTATTATTTAATCTTTCTGTTAGT
+TCCCTGGTAGAAAGCTGTTTAAAAAACTGAGGCATAGCATAATCCTTTCTTTAAAACAAA
+ATTGATTAATCTTTTACTACCTGAACACCCTTCCAAAAGGCCACCCGTCCCTTAATACCT
+TTTGCCAGATCACTGGGTTCGGGATAGTACCATACTGCATCGGGATTGGCTTTACCGTTT
+ACTTCGAGCGAATAATAAGAAGCGGTTCCTTTCCAGGGACACACTGTATGCGTTTCACTG
+GTTTTTAAATATTCTTTTTTTACAGAGTTAATGGGGAAATATGCATTTCCTTCAATTTTC
+ACGATGTCGTTGCTTTCGGCAAGGATCGTATTATTCCATATAGCTTTCATTTTTTTTAAT
+TTTATATTTTAAACTTGTTATTTTATGATTGGTGAACTTAAATCAACAGATTAGACGGAG
+TTATTTCAAATCCTGACATCGCTTATTGATTTTTTGAGAAACAATTATAACAAAATATTT
+CCAAAAATTTGGTAATACAAATTTTAAAACACAATTAAAGAATGTGAAATGATTTAGGTT
+TTTTACTGTATTCGTATGCATTTGCTTAGTTTTTATAAGCTGTTTAAAATTCACAACATT
+TAAGACTCTCAGTTTAAAGGAATTTAAAACTTTCACCCTTTCTGTTCTGGTTCAACAAAA
+TTTGTCACCTCATTTAAATATCCGTGTACCGAATTTAATTCCGGAATTCCTTTAAGCGTT
+ATATTGTAATCCCTTCCCTCTTTATGTATGATGGTCTTTTTAATTGCACCGTCATGTATC
+AATTGATTAAGATTAATGTCTTTAATTTCGGGTATTATTCCTGCAAGATTCTTTCCGGTT
+AATTCATCAGAACCAAAGATATCTTTGGCTGCCTGGTTTGCTTCATTAATAATACTGTCT
+GAATTAATTCTAAAAAGGGGAGTTGGATTATACCGGGCAAAAAGTGCCAGACTTTTAAGG
+AGTTCATCACGGTTTCCTGAACCGGAAAAAATTCTTACGGGGCGCCAGCGGGTCTCCTTT
+TTACATATCGGGCATTCTTCCACTTCGTGGCCTATAGGCACATGGATATGAGTTTTGTTG
+CAGCTTTTACATTTTAATATGGCATCGATGTGCGATACGGAACCGGTCCTAAGTGCACTA
+TTACTTAATACCGATGAATAGGTTGATACCAAAAATGGGACTATGAAAGTAAGCAAAACC
+CTTCCTAAGCTTAGATAATTTGTAGAAAAATGGAAGATAAAATCCGGATTATTGATCAGG
+TTCAAAATGATGCCTACCAGAATAGCTACCCGTATTGCACGTATCAGGGTTTTCTTTTCA
+AATGCCAACAATAAATAGTACTTAATCATTTATGATAGCTTATTTTAAATATCGAGTAGC
+TTACCTGTCTGTGGGGCGAAGGGTATGGGGCTGTTTCGAATAAAAACATATCATTTGAAT
+TTTACCAGGGAAGCTGGTTCTATTCAAAACTTAAAATCATGAAACTTTTGGTCCGTTGTA
+ATTCATTTTACAACCAGGCCTTTTTTATACCAATAGTACATCAGTTACAATTTCCAATAA
+AGCAGTCCCCTTATAATCCAGAAATTCCTTCATTTTAGTTTTCAAATCCTTTCTTTTGGA
+AACCTTTATCCCCAAGGCTCCGCAACCTCTGGCGTATTCAGCAAAATCAGGATTATGCAT
+ATCCGTGGCAAATTTTTTAAAGCCGCCTGAACGCTGTTCTTTGGTAATTTTTCCAAGTTC
+CGAATTGTTTAACAAAACAAGCTTAATATTCATGTTATATTTAACAGAGGTGGCAAGCTC
+GGCCATGTATTGTGCAAATCCCCCATCACCCGCGACGGCTACTATCTGGCGTTTCCCTCG
+CGTTGCAGCCCAGGCTCCCAATGCAGCGGGAAATGCAAATCCAATGGAACCGAGATAACC
+TGACATGAGAAAACTTTGGTTCTTACTTTCAAAATATCTTCCCAGGGAATAGGCATTGTT
+ACCTACATCAACACAAACAACAGCCTCCGGATGAATCAGCTTGGATAAATTATCGAAAAC
+AGCTATTGAACTTATCCCTTTCCCACGATCCTCCAACAACCGTTTTTGTTTTTCCGTACG
+CCAGATTTTCCAGCGTTGCGCTAATTCGGTCCTCTGGTCAACTGTATTTGGCTTAACCGG
+TAATCGCTTCATCAAAATGTTGACTGTAGTGGACAACTCACCCCAAACCGGGACATCAAT
+TTTATGAAATTTACTCAATGCCAGCGGGTCAAAATCAACTTGTATAATGGGCTTTTTCGG
+TGTGATTCCGGTATGGTTACTGAAAGAAGCACCCAGTACAATGAGTAAATCGCTTTCGTT
+CATGAACCAGGAAGCAACCGGCGTACCGCTTCGACCAAGAACGCCTGCGGCCAGCGGATG
+GTCATCTGGGATTAACCCTTTTCCTTTAAAAGTTGTCAAAACGGGGGCGTTTAGATGTTC
+GGCAAATGAAATTATTTGTTCCATAACGAACCGGGCCCCATGACCAACAATAACTACCGG
+ACGTTTTGATTTTGTGATAAAATCTACAGCTTTATCCATACTTCCGGCAGCTGGTGAAAT
+TTGCAATTCTCCCATACGTCCTTCCGGGGTTTGGGATTCTTCTTTACCCTCAAGTATTTC
+CTGAATTTCATCAGGAAAAGTGAGATGAGAAACGTCCCTTTTTAAGAGGGCATGCTTAAT
+GGCCAAGCTCATCAATTCTGCATGTTTACTATCTTTTTGAACCCGGTGGTTAAAAGCTGC
+CACGGTTTGAAATGCCCTAACGAGGTCAACTTCCTGAAAATTACCTGTGCCTACCACCTG
+TGTTGCCACCTGGCCGGTCAGGGCCAGGATTGGGCTGCGATCAACCTTTGCATCCCACAA
+ACCTGTAAACATATTGGTTGCCCCCGGTCCGGCAATTGAAAAACAAGCCGCAGGTTTACC
+TTTTAATTTACCATAAGCGCTGGCTGCAAATGCACCGGCTCCCTCATGTCTGATGGCTAT
+ATATTTCAGCTTCCCTTTTTCTTCCTGTCTTCTGAATGCATCAGCAAGTCCTAAATTTGA
+ATGCCCGACCATTCCGAAAACTGTATCAACCCCCCAGTGGACCATCGTTTCTACCATAAT
+ATCCGAAAGCGTCGTTTTATGCGGTTTTTTGGGAGGAATACCTACAAAAATCCCGTTGCC
+CCGTTCTTCTACCCGATAGGTCGCAACCCCATCATCAAATCCGGGGGCTTTTCCGGTACA
+GGGATGATAATCCCATCCATGCCAGGGACAACGTAAAATACCGTTTTCAATACTTCCTTC
+ACCCAGGGGACCTCCCTGGTGGGGACAATGGTTATCCAATGCACAGATTTTTCCTTCAAA
+ATGAGACAGTGCAATTTGCTTGCTTCCGGCGTTGACAGTAATAATCCTGTTTTCAGGCAG
+GTCTTCTTTTTTTTCAAGAACTTTATGCCATTCTAAATTCTCTTTCATCTGTTGATGTTT
+TATTGTTTACAAGTTTAAAAACCAGTCGATACTTTCTTTTATGTAAGTGTTAATAATTTC
+CAAAGCTTTCGCCGTAGAATTATCAGCCAAGACATGCAAGGGGAGAACGGTGCCATTCCA
+TTGTTCTCCGGTTACCCATCTGCCAAAATTTAATTTGCTTAGATTATTATAGATTATTAT
+AGAAGAATTCTTATATCCGCTCAAATAATAGTATGGTTCCCCTATCATTGAATCTGCCAT
+GGCCCATCCAAATCCAAATCCCAGCGAATCTGTAACCTGAGCATAAACGCCCGTGTCAAA
+ATGATGCGGCCATATCCGTATTTCACTTTCCGACTGAAGATAACCTAACACAGATAAGCA
+GGCAAAATTGGCAAGTCCCCGGTAATATATCCATTGTTTTATACCAAAGGATGATATTCT
+GTTGGATTTTATGATGGAAAAACCGTAATCAGGTATTTCGAAATGTAACGGCTTCGATAT
+ATCCTTGCTGCTCATCCCCATTGAAACCGGGAATTCCCGGATTTCTTTTTCGATGGATGA
+CCCCTCTTTGTCAAAAACAGAGATGGATGTTTTTACTGATAATGGATTGTCCAGCCATTC
+AAAACTAAGGGTTTTCAGGTTTAAAGCCAGGATGAATTTACCTTTTGGAGTGTTAATCCA
+CCTGCCAAACAAACGTTTACCTGCAGCATCCAAAAAAAGATTAGTATGGCTGTCATCTTT
+TTTTGCCGGAACGTAGTCCCGGTTTACTTTTGCAATGGCCTGGCTGAGCCAATGAATCTG
+CCGGTCGGTTTTAATATATTCCTGCATAATTTATCCCTGCTATTGTCTATGATTTCTAAT
+CGGGCAATGAATGGTAATTGTTTAATTTTATGCAAATCACAAATTTATTTTGTAATGGCT
+ATAAATGGATTTTTAAAGACTCTGATTGGTTTAATTTTATGAAAAAGCCAGTTTTAACCT
+TTTAAAAATATTCGGGGCATCTTTGTTCTTTTTATAAACCACAAGCCCAACAATACTTCC
+AAAGGCAATATGGGCAAGATAAACCGTAGTGAGAAACTGGTATCCGTCTTTAAAATGCAA
+TCCGAACACCCCGATACCTAAAGAGGTTGTAGCCGGACTCACCATAAATCCTGTCCCGAT
+AAGTAAAGCGTAAACAATACCCATCCAGATTTTGCCACGGCCAATAATCAAACTGAAGAT
+GATGCCAAAGGCCGCGCCATTCCAAAAGTGATAGGACCACCCGGCTACGTTTGACCAAAA
+GTCAGGGCCTGAGGCAAAGCGGTTGAGCAGCAATACCCCGAGTAATTTGGGCATATCACC
+CGGCATTCCGCCGAGGTGGAAACCAATCTCCCTGACAATTTCCAAGCCAACGGTACCAGC
+CAGTCCGGCCAAAATCCCGTTTAAAATTTGTTTTCGTAAATCATTATATCCGAGTGCCTG
+AGACAAGATTGCCAAAATAAAAATAAGCACAACGGATGGAATTAATAACACAACGGCCAG
+GGATGACATACTTGCAATACCAGACTGTGCAGCCGGAAAAATGTTTGGGGAAATCCCAGC
+CAGCAAAAGCACGAACGCAAGCAATACTAATTTCTTCTTTTCCTGATTCATAACAGCATG
+TTTAAAAGTTTTAAAACAATTTATGAGGGTAGTCTAAAAAGCCTTCAAACTGCTGATTTT
+TATGCTTTTTAGACCCGTCTCATTTATATTAGATCGTAAAAACGGCCGGATGGCATTTTG
+CACACCCGGCCATTATAAATGGTTTACCGGGTAACCATTTTGAGCATCATCCCTAACTTT
+TTATCCAGCATTTGGCCAATCATTTTGACCTTTGCATTTTTAAAAGACCCAAAAAGGTCG
+GACGGTTTAAAGTAACTTACATAGGTCTTGCCGTTTTCTTCGTAAACATTGACCCTGACG
+GGGATTACCAGTCCGGCAGCCGGATCTGCAGAAAACGCTTTGTTCCCTACATTGGGATTA
+CCAATAAAGAATGAATGTGACTTAACGCTCAAACCGGTCATAGATAATATCTTACCTTGG
+TCCAGTTGCGACATGACCATCATACCGCCGCCAGAGACAGCCTTTTTAATGGCATTAATG
+GTTTGCTCAAAATTTTTAGAGGATTGAACCGTAACCGGTTTAACGGATTGGGCCTGTATG
+TTTGTGGAAAAACTTAAAAGGCCTGCGACTAAAACTGCTACAAACAGTGTTGAAAGTCTT
+GATTTACTCTTTTTCATAAAATTACTTTTTTTAGTTAAAAATTAAAACTGTTCACTTCCA
+AAAGAAAAAGGTGCAATTGGTTGATGAACTTAATGTCATCATAATAGACGGAGCCTGTTC
+CCAATCCTGACATCGCTCATTGTTTTTTTTTGAAATTATTTTCAGCCACCATCGTTTCAG
+CACACAAAAGAGGCTTACCTCTTTGAGGCAGCCTCTAATCTGAATCCCATGGAATTCTTC
+GAATCGTTCTAAACGTAATACTTTTTACTTTGCCATTTTTTCGGAGTTTGTCAAAGCCTC
+GGCCAGTTGTTTATTACTTCGGGCAAGGCTGATATGACTAATCAGGGATTTGTTTTTGGC
+ATCGAAAAAATACACTACTCCGGTGCTTTTAAATTTGGACATTGTTTTATAGAGGTCCAG
+TTTTTTTAACGTTTCGGCTGACTTTTGTTTGGTCTGTTTGTTAGATAAGTTGTTAAAAAC
+AAACCGGACAGCACCATCCTGATTGTTATGCATCAAGACAGACATGGCTCTTTTACCATT
+CTTCTGACATACTGGGCACCAGCTGGCTTTGTTTACCACGGCTATTACCTTTGACCCTGA
+CTGGGCCATTGCTGAAGCTGACACAAGAAGTACCAGCATTAAACTTATGACAATTGATTT
+TGAAGTTTTCATTTTACCAAAAAATTTAAAGATTAATATTTAGAATCGTCGGGAAAATAA
+ACAATACCTGACACCTAAATTTAATTTTAACATTTTTTTAGTACAAATTTTACGAATAAC
+AATTAGTATCTACCTGTTTTTGAGGTTATTTAATTTCAAATCAACTTAGGTATTCCTGGC
+AAAAAAAGTTCAGCAAAACTTATATTTAAAAAGTATTGCAAAAAATTAAACTTAACGGAC
+GGGGAGAAAATACCTCAGTTTTCTAAGCGAAATAAGAAAGGCAAATTAAAACATGCTCCA
+TTTCTTTTACAGGCAAGAAATTCTAAAATGCTTTATTTTAATTCATTCAGTTTCTGTTGG
+ATTGATTTTTTTATTTCTTCAAGGTCTTCTTTTTTTATTTTAGATTGGTTTAAATGCGAA
+ATGCCTTTATCCAGAAAAATACTTTGTTTTTCATAGTTTGTGCAGGCATCGCACATCATT
+TTATGAGCTTTCAATTGTACTTTCTCCTTCAGGCTTAGTTTGAAGTATAATTTCTTCTCA
+ATAAGCTCAGTTGCTTTCAAACAAGAAAGAAAGAGTATGTTCATTAGCTTTTTCATCATC
+GTCTAACTCCTAAACCAGTTTTGATCAACACAATCCCGTAATTTAATTTTAGCCCTGTGA
+ATGATTTGCCAGAAATTAGTCGGATTTAATCCCAATTCCTGACAAATTATCTCCCCCTTT
+TTCTCCGATAAGTATTTCATTTTAACACAAGTACTCCATTTTTCCGGTAGCGATTCAAGG
+CATTTTTGCAACACTTGCTGAAACGCACTGTCATCCAGAAGCTGTTTCTCTTCTTGATGC
+CAATCTTTCGGCTCTTTTTCTTTTTTCCAATCTCCCCTTTCGTTAAAGTAAGTAGAAAAC
+ACCTGACTATCAAAACTTACAGGCTGTTTCACTTTATTTCGGTAAACGTCTATGATTTTA
+TGGTTGAGAATGGAAAACAACCAGGTTTTAGGAGAACTTTCTCCTTTGAAAGCATCCATT
+TTTTCAGCCGCTGCCAAAAAGGTGTCCTGAACCAGGTCGCGAGCCAATTCAGCATCTGAT
+ACTTTATACATAGCCCAGGAAACCATTTCTTCTGTGTAGGTTTCTACCAGATAAGTCAAG
+TCAGTTGTTTTGGTCTGGGGCATTTATTTTTAATCTATTGACGTCCGCTAAATTTTAAAA
+TGATAAAATTAAGATATTTTCCGCTCTCCTAAATTTCAGCTATAGTCAAATAGTTTCACC
+TAACTTTAAAGTACCAAATCATTTTTCCACCTTTTCAACCTCCTCAATTAAAAAGCAAAA
+GGCCATCCGCAATAAGCAGACAGCCTTCAATCTATTATCTCTGAAAAAATTCTATTCGTC
+TTTAATAGCGGCAACGCCCGGCAGGGTTTTGCCTTCCATGTATTCCAACATGGCACCACC
+ACCGGTAGAAACATAACTTACTTTATCCTGGAGGTTGTACTTGTTGATAGCAGCAACAGA
+ATCACCGCCACCGACCAAAGAAAAAGCTCCTTTTTCAGTTGCGCGGACAATGGCCTGGGC
+CACATCAACCGTACCTTCAGCAAAGGCATCCATTTCGAAAACCCCCATCGGGCCGTTCCA
+CAAAATAGTAGCTGAATTTTCAATCACCTGACGGAACGTTTCGCTGGTTTCCACACCGAT
+ATCCAGTCCCATCCAGCCATCCGGAATTTCACCGGAAGGTCTGCATTTCTGGTTGGCATC
+ATTAGCAAATTTGTCAGCTGTCACAGCATCCTTTGGAATGAAAAGACTTACTCCTAGCTT
+GTCAGCTTTTTCGCGGGCTGCGTTGGCAGTTTCAATCAAATCATCTTCAACCAGTGAAGA
+ACCTACTTTTCCACCGTCACCTTTGATAAAGGTAAACATCATACCGCCGCCAATCAGCAG
+GTTATCCACTTTGTCAAGCAGATGATTGATGATTTCAATCTTTCCGGAAACCTTGGCACC
+ACCCAAAATAGCCGTAAAAGGTCTTTCTGCATGATGCAGGACTTTATCGAGACTCTTCAC
+TTCATTTTCCATCAGGTAGCCAAACATCTTGTCATTCGGGAAGAATTTGGCTATGATGGT
+AGTAGAAGCATGAGCCCTGTGAGCCGTTCCAAAGGCATCGTTTACATAAACATCAGCCAG
+GTCGGCAAGCTTTTTGGCGAAAGCTTCATCACCGGCAGTTTCTTCTTTGTAAAAACGCAG
+ATTTTCCAACAACAGGACATCACCGCCTTTTAATGCTGCTGCTTTCTCACGAGCTTCATC
+TCCAATGCAATCGTTAGCGAACTGCACCTCTGTTTGAAGTTTTTCTGAAAGATTTTTTAC
+AACATGACGTAATGAGAATTTATCTTCGGGGCCTGATTTTGGCCGGCCCAAATGTGCCAT
+AAGTATAACAGCACCGCCACTTTCACGCAGCTTTTGTATGGTTGGAATGGTCGCCCGGAT
+ACGGGTGTCATCTGTGATCTCAAATTGGTCATTTAAGGGCACATTAAAGTCCACACGGAC
+GATGACTTTCTTTCCCTTAAAGTCGTAATTATCAATAGTTTTCATGCTAAATTAATTTAA
+TTGGATTAACGTGTTACTTCATGCAAATCTAAAAAGATTCGATGTACGAGAATCCTAATG
+ACTCTTAAAAAAGTATTTTTGTATCACAAACACAGCTTATATGGAATCATTTAACGGAAG
+CGTCCAATCGAAATTACCGCAGACAGAGACATCCATTTTTGCGGTCATGTCACAACTGGC
+CAACGACCACAAAGCCATCAATTTATCGCAGGGTTTCCCCGATTTTCCCATCTCGGAAGA
+ATTGATTGACCTGGTGCATTATTACATGCGAAAAGGTTACAATCAGTACGCACCAATGCA
+GGGCGTTTTGCCGCTTCGGAAAGCCATTTCGACTATGTTTCAGAAAAATTACGGCATCCA
+TTACGATCCGGTTTCTGAAATTAACGTTACGGCAGGAGCCACGCAGGCACTGTTTTCTGC
+AATTTCCGCTTTCATCAAAGACGGGGATGAGGCTATCATTTTTGAACCAGCATACGACTC
+TTATGCTCCGGCGGTGAAAATTAACGGCGGTATGGTAAAATATGCGCACCTGGAATTTCC
+GGATTTTAATATCAACTGGGAAGATTTCCCGCGCCTGATAACCAACCGTACCAAGCTGAT
+TATCATCAATACACCGCAAAACCCGACCGGAAGTGTCCTCAGTGAAGATGACCTGCAACG
+GCTGGAAAGAATAACATCCGGAACCGACATCATTGTTCTTAGCGACGAAGTTTACGAGCA
+TCTGATTTTCGACGGCATCACCCATCAGAGTGTTTGCCGATTCCCGGAACTAGCCAAACG
+CACTTTGGTGATTGGTTCCTTTGGGAAAACCTTTCACGCGACGGGCTGGAAGACTGGTTT
+TGTGCTGGCTCCTGAACGCCTGATGAAGGAGTTCCGGAAAGTGCACCAATTCACTGTTTT
+TGCTTCCAATACACCCATCCAGCATGCCATTGCGGACTTTATCGGGAACGAAGACAATTA
+CAAGAACCTGGGTAAATTTTATCAGCAAAAGCGGGATATGTTTGTCAAATCCTTGAATGG
+TTCAAAATTTAATGTTTTACCTTGCTACGGAACCTATTTCCAATTGCTTGATTACAGCAA
+TATCTCCGATAAAAACGAAATGGATTTTGCCCGCTGGCTGGTGGAAAAACACAACATTGC
+CGCTATTCCTATTGCGCCTTTTTATCACAAAAAAGACGACCACAAAGTGCTGCGTTTCTG
+CTTTGCCAAAAAGGATGAAACGTTGGTGGAAGCAGGTGAAATACTGTCAAAAATCTAAAA
+ATATACATCATGAATGATTTGAAAATATTATACATCCAGTCGCGGTTGGCCTGGGAAGAT
+GCCGAAACCAACCGGAAGCATTTTGAGGAAATCATTCAGAAAGAAGCACAGCACCACGAT
+TTGATTGTGCTGCCCGAAACATTCACCACAGGATTTCCAGTGGACCCGGTACCCTTTGCC
+GAAACCGAAGACGGGGAAAGCGTTCTCTGGATGCGTGAAATGGCGGCTCAGACATGCGCC
+GTTGTCACGGGAAGCATGTTACTGAAAAACGATGGAGTTTATACCAATTCTCTCATCTGG
+ATGCGGCCCGATGGCACATACGAACGGTATAACAAACGTCATGTATTTCGCATGGGCGGG
+GAGCATGAAAAGATTCACCCGGGCGATAAAATACTTTTGGTAGAACTGAAAGGCTGGAAA
+ATCCGCCCCATGGTTTGCTACGATTTGCGTTTTCCCGTTTGGACCAAAAATCACTATGAA
+AAGGATGCTTTCGAATACGATCTGGCTTTGTTTGTCGCCAACTGGCCAGCCGTCAGAGCC
+TATCCGTGGGACCAGCTTCTGATCGCCCGCGCCATCGAAAATGAAGCATACGTTCTTGGT
+GTAAACCGCATCGGAAAAGACGGATTGGGCAATGATTACAACGGCCATTCCAAAGTGGTG
+GATGCAAAAGGAAATGTAATTTCGGAAGCCCCGGAAAATGAAGAAGCTGCTATTTCCGTG
+AAGCTTTCTTACGAAGCACTGCAAAAGTTCCGCGCCAAGTTCAATGTGGGGCAGGATTGG
+GATTCTTTTACGATTCAGAAATAAAGAACCTTACAAGTTCAGGGAAGAATTGTCATTCTG
+AACGAAGTGAAGAATCTGCAATAATTGATAAGTATTAATTGATGAAACCCTTCGTTTCAC
+TTAGGGTGACAAAAAAGTTTTACAAAAAAACCAAATAAACAAAGATGAAAAGACTTGGAA
+AACATTTTGCCGTGTTGATTCTTGCCGCCGGTTATTCCGGGCGGATGGGAATGCCCAAAG
+CCTTTTTGCCCTATGATGCCAACCGGACTTTTCTGGAGAAAATTGTCTCAGAATATCTGG
+AATTTGGTTGCAATCTGGTTGGAGTTGTATTGAATGAAGAAGGCATGAAGTTGTATGAAA
+AAATGCAATTGGAACACAAAAACAACATCACCGCCATTCTCAATCCAGCGCCTGAAAAAG
+AACGTTTTTTCTCTCTGCAAACCGGGTTGAAAAGGCTGAAATCAGAAGGAGCGGTTTTCC
+TTCACAACGTTGACAATCCATTTCTAACACAGGACATTCTACAAGCTTTGGCCTCAGCAT
+TCAAAACACAAGCTTATGTTGTTCCAACTTATCATGAAGAAGGCGGACATCCCATTTTGC
+TTTCGCAGGAAATCGTAAAAGCGTTGATAGAAACATCTGATTACGAACAGAATTTGAGGG
+TTTTTATGGAATCTTATGACCAGATTCAGGTTCCGGTAAGCGATCCAAACGTCTTGGCAA
+ATATTAATTCTCCTCAGGAATACGAAAGACTATTTGGAAGATCTTTTTAATAGTTTAAGC
+ATGACAGGCTGAACGCATGTTTTTCTGTCATTTCGAACCTTTGGGTAGCCAGTGTGTTGG
+CGTGAGAAACCTCCCGGGCAGCAGGTAGAAGCTTAGGGGATTTCTCAGTCGTCCCTCCTT
+CGAAATGACAGGGTCTTTCTCTGGGAAACAATCCCAAAAAACTTTCCTTAATTTTGCACC
+CTAATTTAAAATCTCATGGACAAAGAAAAAAAACAAAAGCGCTATCAGCGTTTATACAAA
+CAAATACAGGATTTAATTGTCAAAAGCAGCAACAATCCCCTTTCCAACATGGCCACCATC
+AATGCAGTATTGTATCATAAAATGGAAACTTTCTTCTGGTGCGGCTTCTATCTTTACCAG
+GATGGAAAACTGCAGGTTGGTCCTTATCAGGGTTCGCTGGCCTGCATCAACCTGGCAGAA
+GGCACGGGTGTTTGCCAGGCTGCACTGACACAACAAAAAACGCTGACCGTTCCTGATGTG
+GAGGCCTTTCCCGGACACATCGCCTGCGATTCACGTTCCAAATCAGAAATTGTTATCCCT
+GTAAGAAACCGGGAGAACGAACTCGTTGGCGTGCTGGATGTGGACAGTAAAGAACACAAC
+TCCTTTGATGAGGTTGATGAGGCTGAACTGGAGAAGATTGTAAGGCTTGTTTATTTCCCG
+GAAGGCTAATCTAAAAAGTGTCTTAAATGAACTAAAGTGAGCTTAAGTGACTAAAGTTAA
+GAGAGAACCCCAACTTTACAGACTTTATGAACTTAAGTCACTTTATGAACTCATCTCAAC
+CGGTTTACACAAATGATCCCCGGTATTGCTTACCCGGACACATTTCCGGCAAATAAAACG
+GGGTTCATTGACCATTAAAATAAGCTCACCCAGTTGTTCTTTTATATCGTCTTTGCTTAA
+ATCGCAAAATGTTTTTTTCTTTTTCATGACCTGATGCTTTTTCTGATCGGGTGACTAAAG
+TACGAAACTTGTTTTATCATCCGTAACTTTAGGCATTTTAGGCACTCTATGAACTTACTT
+AATCGCAGGAAAAATATAATCCGCCAGCAGGGCATACTGCTTCACTTTCCGGTTGTAATT
+GGCTCCGGTAAGCACAACGACCGTGTTAATTTCAGGTAGTACAATGATTTGCTGGCCACC
+CCAGCCGTTGGCGGAAAACCAGTGAACAGCCTTTCCATTAATCTTTTCATTCTTTGTCCA
+CCAGTTGTAGGCATAACCCATGTCGCGGAGGTCTTCGCCCGGAAGATCGATACCCCGGTT
+GTTTCCCCAGGGCTTTCTGCTTTTTTCAACCCAGTCTTCAGAAACAATGCGTTTACCATT
+CCAGATACCATTGTTCAGCATCATGGCTCCGATTTTTATCATATCCCGAGGCCTGATTTT
+CAAGCTGCCGGCGGCATGGACCTCGCCCGTAGGATATTTTAGCGCCCAGCTGGCTGTTTT
+TATTCCCATAGGTTCAAACAGATACTTTTGAGAGAATTCATCGAAGGCCATCCCCGAAAC
+ATTTTTCACAATTTCACCTAGTACTTCTACCCCGCCTCCCGAATAATTGAATCGTTGTCC
+GGGTACGGCCACAAAAGGCCGGTTTAGAACAAAATCAAGAGGTCCCTTTTTATGAAAATA
+AATGCCGACCTGGTCGTTCCTTTTACTGCTTAGCGGGGCACTCCATTCTTGCCAGAGCAA
+ACCACTGCTACAAGTCAGCAGATTTTCAACGGTGATATACTTTTTGTCACCCACATTCAG
+ATATTGATACTTTTCTGGCAGGTAATCAAAAATGGATTGATGAATATCTTTAATAAGCCC
+TTTGTCAACGGCAATACCGACGCACAAAGAGGTTATGCTTTTGCTGACGGAATGGGCACT
+GTGGGCCCTATCGGCATCCCAGACAACCATGGGGCCGTAATGTTTTTTAGCCTCCCATTT
+GTAGTCGTGCCCCTTAAAATATTCATCAAGAACCAGTTTTCCGTCTTTGTAAATGAGCAC
+CGAATGAACCTCACCGTATTTACCGCGTTCGACTCTGTTCATGGCTTTTTTTATGAGCAC
+TGTGTCAATGCCTACTTCAGATAAGGTTCCTGTTTTCAGACCATCAGTGGTTTCTGCAGG
+TTGATGATACGAGTACTGGCCTTGTGTGCAGCCCATAGAAATGAAAAGCACCAGCATGGC
+TGCAAGTTGAAAGAGTTTGAGTGTTTGCTTAGTCATGATCGTAAACTTTAGTCGTGAGTC
+AGAAAATACTTTTTGGGTTTGGAAAGGAATGTTTTTCCTTGTTTTTTCAAATATAAGAAA
+TAATTTTAAGAAACACAATGTGAGGGTATTGGAAAGGAATGGGATAAGTGTCTTAAGTGA
+ACTAAAGTGAGCTTAAGTGGCTAAAATTAGAGAACCCAAACTTTGCAGACTTTACGAACT
+CAGCTCTTCTTGAGAGCCATAAGAACTTGTGACGGAAAAGTATTCTGACTGATTTCAACA
+TCTTTGACAATCTCAAAACCAGCTTTTATCAAAAAATGTTTAAAAGACACCGGCCGGCAT
+CCGGTTAAAAGTGCGGGAAATTTCCTGGCTACCCAAAACCAAAAGCGGTGGACTTTTTTT
+GTCCCAAAAGAAAAGGTGGACATGACAACTTTTCCTCCCGGCTTCAACACCCTGAAAAAT
+TCTGTAGCAACTTTATCAAAACAATCAACCGGCAGCAAATCAACCATGTAACTGTTTATC
+AGCAAATCCTGTGAATTATCAGGAAAAGGCAAATCCAGCGCACTACCTTGCTTTAAATTA
+AAATTCAGATGGCCGGTTTTTGATAATTTCTTGCGGGCTTTGGCTATCATATCCGGCGAA
+AGATCAATACCTGAGTTTTGCCCGTCAGGATTCAATTTCACTACCTTTTCCAGCATCTCA
+CCTGTCCCGCAAGCCACATCCAAAACAGAAATTCCATTTTTTATTCCTGCAAATTCCAGA
+ACTTTTTTTGCGGCTTTCCCTTCGGTAAGTTTTCCCCAGAAATCATATATCCAGAGAACT
+TTTTTGAATTCATTTATGGTTTTATTTTCGTTTAAATAGCGTTCTAATATTTCCATTTGT
+TGCATTATTTGGCGGCTGCGATTCCATCACAACCAACTTAGTCGTTTTCCAAAAGTCGGA
+AATAATTTTCAAACAACTGCAAATGGATAAAATTGGCATGGAACGGCACGCGTTCGGAAA
+CACGCGACAGTATTTTGGTAAGAAAATAAGTGCCTTAAGTGAACTAACCTGCCAGCCGGT
+AGGCTGGAGTGAGCTTAAGTGAGTAAATAATCCACCTTCTAAGAAGGTGGCTTTGATTTG
+CCCCCACAGGGGGCTTTAAAAGTCAAACCTTTGTTGTTGGGTTTCTATTTTTTTCTCTTC
+TTCCTCCTGATATTTTACATATCTTTTGATTACATCTTCATCTATTCCTACCGTACTAAC
+AAAATACCCACGTGCCCAAAAATGATTTCCCCAATAGGGCTTCTCCTTTAATGATGGGTA
+ACTCTTAAATAATTTGATGGCCAATTTCCCTTTCAATATCCCCATTAAACGGGACACTGA
+TACCTTGGGCGGGACGGATACAACCAGATGAACATGATCAATTTGAACATTCAATTCCAT
+TGGCTCACATCCTTGCCACTCACATAACATTTTTATATCATTTGTGACAATGTCTTTGAT
+TTGACCCGTCAAAACCCGAAATCGATATTTGGGTACCCATACTATGTGATAATCACACTT
+ATAAACTACATGTGATAACTTCTTATATTTGCTCATGGTACAAATATAAGGCAAAGCATC
+AGTACATTACCACCGTCTAAGACGGTGGGTTTTCAAGTTGAAGTAAAGTTAAGAGAGACC
+CCCAACTTTACGGACTTTATTAACTTAAGTCACTTTATTAACTTCTCAGTATCCAAAAGT
+CTCTACTTCAAAAAAAGACTGCGGATGCAGGCAGGCGGGGCACTTCTTTGGAGCCTTTTT
+ACCTTCATGCAGATAACCGCAGTTGCGGCATTTCCAAACTACCACACCGTCTCTTTGAAA
+GACTTTGCCGGCTTCCAGGTTTTTATAAAGTTTTGAATACCGTGCTTCGTGTGCCTTTTC
+AACGGTGGCAATCATTTTGAAAGCTGCAGCCACTTCTTTAAAACCTTCTTCTTCTGCAAC
+CCGCGCAAACTCAGGATAAAGTTCTGTCCATTCCTCATGCTCGCCTTCTGCTGCTGCCCT
+CAGGTTTTCCAATGTGGTACCGATAATTCCGGCCGGATAAGCGGCAACAATCTCTGTGGG
+ACCACCTTCCAGAAATTTAAAGAACCTTTTGGCATGCTCTTTTTCATTCAGCGAAGTCTC
+TGTAAAAAGCGCTGAAATCTGCTCCAACCCTTCCTTTTTAGCCTGACTGGCAAAATAATC
+ATAGCGCATTCTTGCCTGGGATTCCCCGGCAAAAGCTTTCAAAAGATTTTGTTCCGTTCT
+GGTTCCTTTTAATGATTTCATGGTTAATTTTTTTAGGTTATCGTTTATTATCCAATGGGT
+TCGAAATCTTCTTTTTCGGCACCGCAATCGGGGCAAACCCAATCGTCGGGAAGATCTTCA
+AACGCCGTTCCCGGAGGAATATTTTGTTCCGGATCCCCCACAGCCGGATCATAAATATGG
+CCGCAGACAATGCATTCCCATTTCTGCATGGACTTGCCTTTGGGCTTTTCAGCCGGCGTT
+TCTTCTGCTTTTTCCTCTTTCTTTTCTTTTTCAGGCAACAAGGACTTATCCACGTAAGTA
+GGAGAGTTCTTGGGCGAAAGTCCGTGGCGCACCTGACGGTAGTAGGTATAGGTCAGGGAT
+TCTTTGTTTTCATCGAGATATTCGCCATTAAGCACCCTGCCAATGAAAATGATGTGCGTG
+CCAACATCCACTTTCTGCTCCACCTTGCATTCAAACCAGGCAACGCATTCTTCCGTTACC
+ACCGGGATACCATTATTCGTTTCAAAATACTTTGTCCCCTCGAACTTATCCAGCGTTTTT
+CCGCTCTTATATCCGAAACGGTTGATGATTTCCTTGGAAGCGTCTTTTTCGAGCACAGAG
+AGGCTGAAATAGCCGCTTTCGTCAATCATTTGTTCACTCAGGTTGTCTTTGTTGCAACTG
+ATGGCTATTTGTTCTGGAGAAGCCGTCACCTGAAAAGCCGTGTTGGCGACATACCCGTTT
+TTTTTGCCTTTGCTGGCCGTTCCGATAATATATAATCCGTACGAAAGGGAATAAAAAGCT
+TCAATATTCATGTCATTCTTATTTAATGTGTTACAAGTGTTGTTTGAGGTCTTAAAGGTC
+CTAGAAGCTCTGTTTGCAGGCCTTTTCACCTACAAAGATAAAGGAAAAGTGTCTAAAGTG
+TACTTAAGTTAATAAAGTGACTAAAGTTATTTTCTAACGACAGGGAACAACGTTTTAGTG
+AAAAGGCACGCGTTTGGAAACGTGCGCCAGTTAATGGTTAATGGTTTTAAAAAGAAGGGA
+CGCAAAATTTTGCGTCCCTGCATCTTCGGTCTTCTGACTTCGGTCTTCCGTCTAATCTTC
+CGTCTTCACCAATTCCGGTTTCTTCTTCCGGTCACGGATTTTAATAATCGTAACGTAGAA
+CAACGGGATGAAGAAAATGGCAAGCAGCGTGGCTGTTAACATACCACCGAATACGGTGTA
+ACCGATATTGATACGGGCATTGGCGCCGGCACCTGTGGCAATCATCAACGGAATGACACC
+CAAATCGAATGCCAGTGAGGTCATCAAAATCGGACGGATACGCAGTTTGGCTGCTTCCAC
+CGCAGCTTGCACCAGTGGCACACCGCTCTCGTATTTCATCTTACAGTATTCCACAATCAA
+AATGGCGTTCTTCGCCGCAAGGCCAATAAGCGTGATGATACCGATTTGCGCATAAATACT
+GCTGGATAACCCTCCTATATGCAGTGACAAGTAAGCTCCGAAAATTCCGATAGGAACCGC
+CAGCAACACAGCAAACGGCACCGCAAAACTTTCGTAGAGTGCTGACAGGAAAAGGAACAC
+AAACACTATAGCCAGTATGAAAATGAAAGTACTGGTTTTGCCGCCTTCAATTTCTTGCAG
+CGTGGTTCCGGAAAACTCATACGAATAGCCTTCCGGCAATACCTGTTGTGCCACCTGTCT
+CAAAACTTTAATAACGTCTCCCGAGCTGTAGCCCGGCGCAGCATTTCCACTGATATTCAC
+ATTCCTGTCCATGTTGTAGTGCGTAATGACAGGTGCAGAAGTACCTCGTGTAATATTAAC
+TAAAGCACTAACAGGCACCATGTTACCCTGATTATTCCGGACGTAGTATTCCGACAAATC
+GTTGATGTTGGCGCGATAGCTGGAGTCGGCTTGGGCGTAGACACGGAATGTTCTGTTAAA
+CAGCGTAAAATCATTGATGTAATAACCACCGAGGAAAGTCTGAATGGTATTATCCAGTGC
+ACTCAATGAGACACCCATTTTTTTGGCTTTTACCCGGTCGATGGTCACGCGGATATCCGG
+ATAATTAAACGTGGCCGTTGAATATGCCATCTGTATTTCGGGCCGCTTGTTTAATGCTGC
+CAGGAATTTGTTTTGAACTTTTTCCAAATCCTGAATACTTCCGGTACTTTGTTTCAGGAC
+GAATGAAAAACCGTTGGTCCTTCCAAGCCCCCGGATCGGAGGTGGAGCAATAATCATAAA
+TTTTGCACCTTTAATTTGAGATGAGGCTCCCATCAATTGCCCGATGACGGCCTGAATGGA
+ACTATTTTTCCCCTTTCGTTTGCTCCAGTTGGTGAGGCGGATAAACGCTGTTCCGAAGTT
+GGACATCTGAGCACCCTGCAGCACACTAAAACCGGGAGCCAGAAAATAACGTTTTACGTT
+CTTATTGTGATTTAGAATTTTACCGAATTGGTTCAGCACCTTAACCGTCCGCTGGGTTGA
+TGCATCCGGCGGAAGCTGGGCAATAGCCATCACCATGCCCTGGTCTTCGTTGGGCAGGAA
+TGAAGTGGAAGTATATTTTGAAAATAATCCGGTTCCAATATAAATTGCTCCCAGTAAGAT
+AAACATCAAAGGGGCATGCTTGATAGTCTTTCTAACGGTTGCTCCATAGTTTTCAACTGT
+TTTGTCAAACCAAATATTGAATTTATAGAACATCCGGTTCAGGCCTTTACTGTTTTCGTT
+TACCGGATTGGGACGCATCATAATTGAACAAAGTGCCGGCGTCAGTGTCAGCGCTACAAA
+AGCAGAAAGCAAAACGGAAATAGCAATCGTAAATGCAAACTGTTTGTAAAGCATTCCGGT
+AATGCCGGGCATAAACGTTACCGGGATAAACACAGCGGTGAGGATTAAAGCAATGGCAAC
+AACAGGGCCACCCACTTCACTCATGGCACGGATGGCTGCTTCCTTCGCCGTAAGGCCATA
+GCGGTCAATATTATGCTGCACGGCTTCTACCACCACGATGGCATCATCCACCACAATACC
+AATGGCGAGCACCATTGCAAACAATGTCAATGTATTGATTGTGAATCCAATCAGTGTAAA
+TATCGCAAAGGTTCCGATGATAGATACCGGAACGGCCAACATGGTAATCAATGTCGGGCG
+CCAGGTTTGAAGGAAAAAGAACACCACGATAATCACAAGCAGCAACACTTCAAAAAGCGT
+TTTTACCACCTCATCAATAGAAGACTGCACAAAACGAGTGTTATCAACCATGGTTGTCCA
+GGCCACATCGGTAGGAAAATTTTTGGATAGCTGTTCCATTTTAGCTTTTACCAAATCGGC
+AGTTTCCAATGCATTTCCTCCGGGCGTTTGGTACACGGCCAAACCACAACCTACTTTTCC
+ATTTAATCGTGGGGTTCCGGCATAGCTTGATGAACCCAGTTTCACACGAGCAATATCTTT
+CAGGCGAATCACAGAACCTGTTGCAGGGTTGGTTCCCACCACAATATTTCCGAATTCTTT
+AGCCGTCACAAGTCTTCCTTTCACCTGCACAGTAACCTGAAATGTCTGTCCCTTTGGTGC
+CGGAGAAGCGCCCACCGAACCGGCAGGTATCATCGCGTTTTGTTCTCTGACTGCATTTAT
+AACATCCTGAGTGGTAAGATGTAAGTTAGCCATTTTCTGTGGATTTAACCACACGCGCAT
+GGCAAAGCTGTTACCGAAAACATGCACGTCACCAACACCATCAACGCGGGACAATGCGTT
+TTGTATGTATAAAGCAGCATAGTTACTCAGGAATTTCTCATCATGCGTACCGTGCGGTGA
+ATAAAGCCCGACGATTTCCAGCATACTGGTGGAAGCTTTTTTCACAGAGAGTCCTGTCTG
+CCTGATTTCTGCAGGCAAAATCGGCGTTGCAAGGTTGACACGGTTCTGTACTTCCATGGC
+ATCCACATTCACATCCGTGCCGATTTTAAAAGTAACGTTCAAATTAAAACTACCACTGTT
+GGCACTTGTAGAGTTCATGTAAAGCATGCCCGTAGCGCCGTTCACCGAGTTTTCAACCGG
+TGTGGCCACCGCCTTTTCAACATCCGAAGCATTGGCACCGGTATAATGCCCCGAAACGCT
+TACTACCGGAGGCGTTACTTTCGGAAGCTGGGCAACAGGTAGCTTGAAAATGGAAATAAT
+CCCTACGATGATGATGAACAGCGAGATGACAATAGCTGTTATAGGTCTGTTAATAAATAT
+TTTTGAAAACATTTGTTCCTGTTTTATTCTTTTTGAATCGTTTTACTCAGGCTTGGATTG
+TTTTGCCATTCCTCCGGTTTTCATAGGAACCGTTTTGACTTTTGCTCCTGGTCTGACAGA
+TTCTATTCCTTCAACAATAACTTTAGTTCCCGGCTTTAATCCGCTTTTGATGACCTGCAT
+ATTACCGTACTCTGCGCCCAGCTCCACTTTTTGCTGAGATACAATTCCTTTACTATTCAC
+TGTATACACAAAGAACTCATTCAACAACTGTGTGACAGCCTGTTGGGGAATCACAACAAC
+TTTACCGGCGCTGTTTTGCGTGGAGCGAACCACACAGTTCATACCTGATTTTAGCAGATC
+TTCCGGATTGGGAAATTTTAACCGAACCATTAAGGTTCCTGTGGTGGGATCCACCCGGTT
+ATCAACAGCATACAACTTGCCCTTGTAAGGATACAATTTTCCATTAGGAAGTACCAGGCG
+GAAATGCGAAAGCTTTTCTTTGATGCTCTTATCGCTGGAACCCAATTGCAAATAGTCATT
+TTCCGTAATGAAAAAGTCAGCATTCATATTGCTGTTGTCCACGATGGTTACCAAGGGTGT
+TTGATAGGCTACCACTACATCGCCAAGACGAACTTTCGAAACATCGGTTGAACCGGAAAA
+TGGTGCTCTTACAGTGGCATGATCCAGATTGGTTTTGGCACTTTCCAGGTTAGCTTTGGC
+AGCGATAACAGAAGCTTTTGCTACGTTTACCTTGGCGATAGCATGGTCGAGCTGGATTTT
+ATCTACTGCATTGTGAGCCCACAAATTTTTATAACGACGGGCATCCGTAGTATCTGTAGC
+CCAGTTTGTTTCAGCAATATTCAGTTGGGCTGCAGCCTGATCGTAAGCAGCCTGGTATAA
+ACTTTTATTGATGGTATAAAGCGGCTGGCCTTTCTTCACAGAGCCGCCTTCCTTAAACAA
+AATATCTTCCACCCTTCCGTTTACTTCCGATTTCATAGTAATTTGCCTGTTGGCGACAAG
+TGTAGCGGAATATTGATCCTGTATCGGAGCAATTTTGTCTTGAGCAGTCGTCACCACCAC
+GGTTGCCATTCTGCCGTACATGCCTCTTTTCTTGTTTGTTCCGCACGAAACCAGTAGAAA
+TGAGAGAGCTATTGCTGATATTATTGTTATTCTTGATTGAATCTTTTTCATTTGTGATTC
+CATTAAATTGTTTTTAAGAAGTCCGAAGACCGAAGTCGGAAGACCGAAGAGGTCTAAAGC
+CTGGAGTTCGGAAAATATTATTCATTATTTAATTTTTTCTCTAAAAGCAACCATCATATT
+CATCAAATTATAAGCAAACTCATATTGCTTTTTAAATTCATCTTCAGTGATGTAATTTCT
+TCTTTTAGCTTTATGCAAGCAAGAAACAACTTCCGCCAGCGACCTAATAGCATAGGACAT
+AAACTTTTTGAATTCCAGATTAGATTGTCCGATAGAACCTTCAGAAATATTTAAAGCAAT
+TGAATCGACAGCCCTTCTTATCTGGGATGAAAGATTATACACTTCATCCTTTGGGAATTT
+ATGAGCTATAGAATTTATTTCCTCTCCAAATTCCATGGCTTTCTGCCAAATAATTAATTT
+TTCAAACTTAAATTCCATCTCTCATTAAACCTTATAGTTTTATTCGTCCCTTCTTCCGAC
+TTCGGTCTTCCGACTTCCGACTTCTGACTTCCGACTTCTGACTTCCGTCTTCCGTCTTCC
+GTCTTCCGTCTTCCGTCTTCCGTCTTCCGTCTTCCGTCTTCCGTCTTCCGTCTTCCATCT
+CTAATACTTTAATTTCCCCAGACTCTTATCCAAATCAACCTTATCGACCAGCGCCTGATA
+CAACGCATTGATGTAATTATCCTGCGCCTGAAGTAGCGTCGTTTCTGCATTTAAAACTTC
+GATGAGTGGCTGCACACCATTATCATACTGGTATTTCAGATTATCATAATTCAGTTTGGC
+CAATTTTGTATTTTCTTTTTGTGTTTTGAGATTGGCGATATCTGATTTGTATTGCCTGAA
+GTAGTTTCCATATTCAAGCTTGATGTTGTTTTCCAAATCACTGATGTTATTCTTGGAGAT
+TTGAATGTTCATCTTTGCAGCCTGATATTGATAATGCTTATTAAATCCCGAAAAAATCGG
+AATACTCAGTTGCAATCCAACGAAAGATGTGGGATAAAGTTTATCCTTAAATAACCCGGG
+AAAAGTATTGCTGTTATAAGGCGCTTCCAGTGTGTAAAATGCAGACAATGTTGGAAAATA
+GCTTCTAATAACATTGCTTTTCAACAGTTTGGTTGCTGCCAGCGTAGTTTGTGCCTGTTG
+GAATTCGACTCTGTTTTTATAAAACATCGGATTGTTCTCCGGCAAGATTTCCGTAAGCAT
+AGCATCGCTGATGGTTCCTTTGATTACCAAAGAATCTTTTATGGGCATTCCCATGTGATA
+TTTCAAAGTCTGAATCAGGGTATTAAGATTTCTCGAAGCATTGGCACGAGCGGTAACGTC
+GTTGTTCACCAACACCTGTATCCTATCCACATCTACTTTTTGCGCCAGCCCGTTTTTATA
+CTGGTTTTTGGTATCTGCCAAAGACTTGGTATCACGTTTGATATTCGCATTCAGCAAATT
+CAGCTGTTCGCGGAATACCAGTACACCATAAAAAGCCTTCTTGACATTGGCGGCAACATC
+AATTTTGGACAGTTGGGTGTTCTCTTTTGAAAGATTTTCGGACAAATGAGCAGCCTTAGC
+GCTTCCTAATACAGAAGGATCAAACAAGGTTTGATCTACATTGAGATAACCTTGCAATTG
+ATGAGGAACACCAAATAAAACAGGATTTCCCTGAATAAAAGAAACCTGCCTTTTGATAGT
+ATATTGATATTTAGCTCCTGCACTCACCTGAGGCATCAGCTTGCTGTATGCTTCTTTGAC
+ATTTTCCCGGCTGATTTTCTCAGACAATATTTTATTTTTTACACTAGCCTGATTCTGCAA
+CGCGTAATGAATACAATCATTCAGATTGAATTGATACACTGCTTTTTGTCCTTGGGCCTT
+TAAGCTCACGGAAAATCCGGAAAGCAAAAAAGAAACAGCTAAAAAAGCACTGAAAAATTT
+ATTCTGATTTAACTTTTTAAGTAGCATTGAACTTCCTTTATTGTTTTTGACCATTTAGGG
+GCTTCATTTTGTAATTGGTTTACCCTACAACTAAAAATGAAATGCAAAATAAACGAAATT
+TAGTTTACCCCACAACTATTCCTATTAAGAAATCTTAAACTTTTTAACATACATTAATTT
+TCCAAACCCGTTGCCGGTATTGGTTTTCAATAATATGTAAGAAGATCTATACATCAAATC
+CTTTTCAATTAATCAATCTTACAAAACTACTTGTGGGGGATTAAAGCCGAAATGGCTTCA
+GACTTCCATCTTTAAAAATTACAAAAGAAATTGAATCCTTTTTAGACAGATATTTGTTTA
+AAATGTATATTAATAAAGGCTTACGCCTGATTTTTAATCACTTAAGACAGCACCTTTCTG
+TAATACACAAATGCACTGAGCCAGCTTATCAGCATAATAATTACAACCCCCACGCCCAGC
+ACACTGAAATCCAGGTGATTTAAAAAACTGAAAAAAGACAGACTTTCTTTCGCCTCAATA
+GACACAACCTGCAACCACTCAATCGTTCCGATGGCAAGTGCCACAAAAACACTGGTTCCT
+GTAATGACCATATTAAAAAACACTTTTCTTACGGCATCAACCATAGCCCAGTCATAAATT
+CTCATCATGATTAAACCGTCCAGCGAATCCATCAGGCTCATACCTGCAGCAAATAAAAGC
+GGAAACGCCAGGATACCCCAAATGGGTAGTTGCGAATCTTTCGCCACCGTGGCCGAAATT
+CCAAGAATGGCCACTTCTGTAGCTGTGTCAAAACCCAGTCCAAAAAGAAATCCCAAGGGA
+TACATTTTGAAACTTTTGTCAATGGAACGATAAGCAAACCTAAAAAATCTGTTTAACAAT
+CCTCTCTTATTCAGTAAATTTTCAGTTATTTCTTCAATTCTTTTTTCTGCACCTTCACCT
+TTCTTGTACAGTTTAAACATGCGATAAAGGTTTTTAAGAATGAAAAAATTGATGATTCCG
+ATCAATGTCAGAAAACTGGCAGATACCACAGTACCAAGAACACCACCGATATTTTCCAAA
+AAGTGAATGTTCGAAGAAAATTTTCTGAAGGCAATAATAATTGCTAAGGACAATAGTAAA
+ACCACAGTTGAATGTCCCAGTGAAAAAAACAATCCTACCGATACAGGTTTCTTTCCATCC
+TGCCTCAGTTTGCGGGTTACATTATCAATGGCGGCAATATGGTCAGCGTCAAAAGCATGA
+CGCAATCCAAAAAAATAAGCCAAAGGCCCAAGACTTAAAAGCGGTAGTGAGAATTTTGAA
+ACCACAATTAGAAAAGCCCATGCTGATAAGTTAAAAAGCACCAGAAAAGTTATCAGGGAA
+TATGTTCTTTTCTTTGCAGACTCCATTGCCTTTCGATTATTGTTGCGGTTTTCTTAAAAA
+GTTAAAAATAACAAAATTATATAAAATTAACAGGTAGAAATCATTTGGTCTAATTTAGAA
+ACTGTTAAAATATTCTATCGATGCATTAATTGATATTATAAAAAACCAGAAAATCTTCTC
+CTGAAGAAAAATATTATTTTTCGGAAAATTGCCTGATAATTTTATAACTTTGGAAACTGG
+AAGAAATACCCCAGCGGGTAAAAGATACCACAGGCAATAGGTTATTGCCCAGGTCAAAAG
+AAAGTAGATAGATCTAAATACAAGTACTATGGATGCAGGTGAGGAAAAGGCGTCTCCCAA
+AAAAACAATTCTGATTGCTGAAGATGATGAAACCAGTTTCTTTTTTCTGAAATTTGTGCT
+GGCGAAAGAAAACGTGAATATTCTTTATGCACAATCAGGACAGGAAGCTGTTGATATCTG
+CGAGGCTCATCCGGAAATTGATCTGATTCTAATGGATATTAAAATGGCCGGCATGAGCGG
+GATTGAAGCAACACAGCTTATAAAAAAACGAAATCCGCGGGTTCCGGTTATTGCACAAAC
+GGCTTTTGCGCTCAGCAGCGATAAAGAAAATATCTTAAAAGCCGGATGCGATGACTACAT
+AACCAAGCCCATTCGCAAAGAAGAACTTCTGGAAAAAGTAAACTTCTTCCTCTATTCTAA
+AAAGGAATCATAACACGATTTTCTCTTTTTTTTCTTTAAGCCTGCTATCTACTAATCAGC
+AATAAACATGCTGGTTTTTAAGCATTTTCATTGAAATGGAAAGCGCTGATACCGCAGGAA
+TTTTTACTATTTTTGCCAACAAATTTTTTCAATATGCTTGCCATTTCTATTGTTATTCTG
+TTGATTTTATCCTTTCAGGTTATGCCTGTCGCATTAGGTATTGATAGTCATAAAATGAAT
+GTGTTTCATGTGGCATCCAGCATATTTCTGCTTATTTTGGGCCAAGTGTTGCTTTTCCTG
+CTGGGTATCCTCCTGGGCGATAAGTTTATGTATTTGATGAGTGGGTTTAAACGTTTTGTT
+TTATTCATTGGGTTTTTCATCATCGCCACGAGAATGATTATGGAGGCGCTTGAAATCAGG
+AAGGGAAAACGCACTTACCTGCTTGACAAGGCGAAACAGTTTATTTTACCTTCCATTGCT
+CAGGCCATCAACACTTTTTTAGCTGGAATCTTGTTTCAACTTCTAATTTTCAATCTATCG
+AAGGATCTGATTTATCTCGGCATCTTCGCACTGGCATTCTCAGTTCCTTTTATTTTCATT
+AAAAATGAAAAACAATCTATGCTTGCGGTTTCCCTGCTCTATATGGTCGGCGGAGGTATC
+CTGAGCATTCTCTCATTTTACTTTTTATTTATTTGATTTTCAATTTCTTTCCATGAAAAA
+GCATTTAAACATAAACGAACCAACACGCATCCGGATAACCAAAGAATTTAAGTTCGAAAT
+GGCACATGCCTTAAAAGGATATGATGGTCTCTGCCGAAATATTCACGGCCATTCTTATGA
+ACTAATGGTGACCGTTTCCGGTTTCCCCATCGAAGAAGAAAATCATCCGAAACTAGGCAT
+GGTAATGGATTTCGGAGATTTGAAAAAGATTGTCAAAGAAGAAATTGTAGGTCAGTTTGA
+CCATGCTTTGGTACTTTCCAAAAAGATGCCCGTTCCTTTAGTGGATGAATTGAAAAATCA
+ATTTGAGCGCATCATTCTTACCGATTACAATCCCACCAGCGAGATGATGCTCATTGACTT
+CGCCGCCCGGTTAAAGGCACGACTTCCTGAAAATATTACACTGAAACATATGTTGCTCCG
+GGAAACGGTAACGTCTTACGCAGAATGGTTTGCTGAAGACCAGGATTAAGAATTCACTAA
+AAAAAGGTAAGTGGCCCTGGTCAATTAAGACCATCCTTTTCTCAATGATGTTTTAAACAT
+TCTGCAAATAGGTTTATTAAAAGATCAAAAACCACATTTACCGGGAAACATTTATTTAGC
+TATTTTTATGGCGCTTAAAAATTGTGGAAGTTATGTATAAGAAATTATTACTGTTAAGCC
+TGACCTTTTTCATGTTCACAAGTTTTACAAATATTGCTTCAGCCCAAAGCAATAATATTG
+AAATTGCCCGGCTGAAACAAATTCATAAATTACTGGACTACAGATTTGTAGGAGGTTTTT
+ACGGTTTTGAAAAACTCTTTTTTCAAACTGTTTCTTATCCCGACGAGGCACGGCAAAACT
+GTACGTTGGGAATTATGATTGCCTCTTTCACTGTCAATTGTGATGGCGATTTAGTAGGTA
+TCAGGATCAGAAATTCTTTGGGTAAGCCACTGGACAACCAAGTCAGTAAATTTCTTAAAG
+CAACAAAAGGGCATTGGAATCCTTGTCAGGATAAAAAGTTTACGCATTTTGAAATTCCTA
+TTCAGTTTACACTGAAAGGAACAGAAACAGACTCCACAGCTGCTGCCCTTGTTTATGTGG
+GCAAGAGTGCGGGTTATTCATGTTACCCGGATAGTTATTACAGTGTTCCTAGGCTGTTTC
+CTGGTGGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTGAGTATTCTATAGTCTC
+>NODE_39_length_1472_cov_66.0355_ID_77
+GGCCTGGGCGATCTTGTCGCCGTGCTCGTCGGTGCCGGTCTGCATACGGACCTGGCGGCC
+GGCCAGGCGCTGGTAGCGGCAGGCCACGTCGGCCACGATGGTGGTGTAGGCGTGGCCCAG
+GTGTGGTTCGGCGTTGACGTAGTAGATGGGTGTGGTGAGGTAGAACGTCTCGGACATGGT
+GTGTCAGGATCCCTTCTTTTTCCTGCGTCGATTGCGCGAGCGGGACTTGCCGCCCGAGTT
+GGTCTGCTGCTGGCCCTTGCCCTGCTGCTGGTTGCGCTGCTGGCGCTGTCCGCCGCGGGG
+CTTGGGTGGGGCCTGGGGTTTGGCCAGAGGCTCCAGTTGCTCCAGCTCCTCGGGGGTACC
+GGTGAACTCGCGGCCGTCGCTCAGGATCACGGTAAGCTGGCGCTTGAGCACGTTCTGGCG
+GATGACCTTGCCCTCCAGGCCGCTGTTGAGGCTGACCCTTTTCCCCAGCTTGGGCATGCC
+CTGCTTGAGGCCCTTGTAGGTCTCGAACTCGTAGGTGAGACAGCACATGAGCCGGCCGCA
+GAGCCCGCTGATCTTGGTGGGGTTGAGCGAGAGGTTCTGCTCCTTGGCCATCTTGACCGA
+GACCGGTTCGAAGTCGCGCAGGAAGGTGGCGCAGCACAACTCGCGGCCGCAGGAGCCCAG
+CCCGCCCAGGAGCTTGGCCTCGTGGCGCACGCCGATCTGGCGCATCTCGATGCGGGTTCG
+GAAGCGGCTGACCAGGTCGCGCACCAGCTCGCGGAAGTCCTGGCGGCCCTCGGCGGTGAA
+GTAGAACATGAGCTTGCTGCGGTCGAAGAAGCACTCCACCTTGACCAGGTTCATGTCCAT
+GCGGCGGGCGGCGATGCGCTCCTGGCAGTAGCGGAAGGCCTCCTTCTCCAGCTTGGCGTT
+CTCCACCAGCTGCCGGAGGTCTTCCTCGGTGGCCAGGCGGTAGACCTGCTTGAGCTGGGC
+GGGCTCGTCGCCGGAGTCCTCGCAGCCCTCGCAGCAGCGGTTCTTGGGGGCCAGCTCGGG
+CAGCACGTGGCTCACCGGCGGGCGCACCACCTCGCCCAGGGCCTGGCCCTGCTCGGTCTC
+CACGATGACCATGTCGCCCACCGAGAGCACGAAGTGGCCGGCGTCGAAGTCGTATACCTT
+GCCGCCTTTCTTGAAGCGGATACCTACGATCTTGCCCATGAGCGTCCCTTGGCGGGTGTG
+GTGCCGTCTCGCGGCGGCCTGCCGGTCGTCGGCCCGGTTCCCCTGGCGCACGCCCCGGTG
+GGGCGGCGGTTATATTCTACAGGCGGATTGCACGCTTGGCATCCCCTGCCCCTGCCGCGC
+GCGGGGTGCGGAGGCTATTTGAGGCATGGTAGTGCAAAACCGGCCGCGGCACAACCCGGG
+CCTGCGGGTTTCGCATTGGCGCCGGGTCTGCATCGGGGGGCGCACTTGGTTTTTCTGACA
+AGCTGCCCGACCCCCTACGGGAGCCGAAGCCG
+>NODE_3_length_39215_cov_155.142_ID_5
+GAGACTATAGAATACTCAAGCTTGCATGCCTGCAGGTCGACTCTAGAGGATCCCACCAGG
+AAACAGCCTAGGAACACCAGCACCGCCAAGGCCTATCTGGACGAACACTTCCAGCACAAA
+CTGACATTGGAAACGCTGGCCGGGGTCGCTCACCTGAGTGTGCGCCAGCTTAACGAACTG
+TTCCGGCGCCAGATCGGCATGACGCCCCATCACTACCTGACCGAAGTGCGAATGCAACAG
+GCCTGGCAATTACTGGAAGGGACCGATCTGTCCGTCCAGGCGGTGGCGGAGCGGGTGGGT
+TACAGCTCGCTGGCCGCCTTCAGCGACCGTTTCCACCAGCACTTTGGCCATCCACCCAGC
+CATTTCCGCCGAACCGGCAAAACACTCCGCCAGAATCGGTAAGACACGCACCGTTCCACC
+CCCTAGACTGCCATCCGGAATGAGTCATCCGGGAGCCAGCCATGTCATCGCCTGTCAGAA
+CTGCCACTTTCATTGGTGCGATTTCCGTTGTCCTCTGGGGCACGCTGGCCCTGTTGACCA
+AGCTCACCGGTGGCCGGATTCCGCCTTTCCAGCTGATGAGCATGACCTTTGGCATCGCGT
+TCCTGTTGATGGCCGTACGCTGGTGGAGCCGCGGCGAGTCCGGACTTGGCTATATCCGCC
+AGCCTTTCCCGGCCTGGCTTCTGGGTGTCGGCGGCCTGTTTGGCTATCACCTGGCGTATT
+TCAAGGCCATGACGCTGGCCCCGGCGGTGGACGTCAGCCTGATCGCCTACCTCTGGCCTC
+TGTTCATCGTCCTGCTGTCCGCCCTGCTGCCCGGGCATTCGCTGCGCGCACAGCATCTGG
+TCGGCGCGGTCCTGGCACTGGCCGGCTGCTGGCTACTGGTGGGCCGAAACAGCCAGGGCT
+TTGATTGGACCTACGCTGACGGCTACCTGGTCGCTTTCGGCTGCTCGCTGATCTGGTCGA
+GCTATTCAGTGCTGAGCCGCCTGGTGCGTTCGGTGCCGACCGATGCCGTAGGCTGGTTCT
+GCGGCGTCACGGCGCTGCTGGCGCTGGGCTGCCACTTGCTTTGGGAGACCACGGTCTGGC
+CCGTGGGCACCCTGCAGTGGCTGGGCGTGATCGGCCTTGGTCTGGGTCCGGTAGGGATCG
+CTTTCTTTACCTGGGATCACGGGGTGAAATACGGCAACCTCCCGCTGCTTGGCACACTGG
+CGTACAGCGCACCGCTGATCTCGGTGGTGCTGCTGCTTCTGGCGGGCTTTGGCCAGGCCA
+GTGGAATGCTGTTCCTGGCGAGTGCACTGATTGTGGCAGGGTCGTTTGTGGCTGGCCGGG
+CAAAGCATGCATCACCCGAGCTGGCAGAAGAACCGGTGCCCGAGTAGAGACGGGCTCAAG
+GCGCGGTTAATCCGACGCGCAACAGTCGTCACCTTGCTGGACAGGCGGGCAGGGGTTGGT
+GCCAAAAGAACAGAAGACACAGCAATCGCCGGCCCTCGGCTTCAGTAACGTATGGCAGGA
+CTCACACTCATAGAAATACTGGCAGGCGTCCGTCGGCATTTGTTCGGTTTTTTGATGGCC
+GCAGGCCGGACAGATGATCGTGGATTCCAGCTGGATGTCTTTCATTGCCGCCTACCTTAC
+CAGGTGCGCCCTGTGTGGCCCTGAAAGATTCAGATGCCATGGTTGGCATGGGCGATAAGT
+CCAGCTCCCGGGCCTTTCTCCATCAATCCAACCATTGCTCCTTCTGAATGACAACCCTGT
+AGCCGTCAACGTCTTCAAAGGTTTTACCCAGTCTATCCCAGTAGGGGTTGAATGACGGCT
+TACAGACAAACCCGGCCTTTACCATCGCCTCGCAGGTCCGCACCCATTCCACCGCATCGG
+GGATATAAAAAGCCAGCAGATGATCCTGTGTCGGGGCCCGGCCTGCCTTCTCGTGCTGAC
+ACTGTGTGAACTCAAGATGGTAGGCGTGCGATCTCAGCCCCAACATAACGCCATCAAAGC
+CATCATGCTCCCTGAACTCTCCCAACCGCTCAAAGCCGAGGCCTTCCATATACATCTGAG
+CAATCTTTTCCAGTTGATCGGTGGGTCTGGCCACCCTTAGAACAGTGCCTTTATTCATGG
+GGAACTCGCAGTATTGGCTTTTGTCGGAGCGGACGTTCTCTAATTCCCCGAATAGCCGGG
+AAAAGACGCAATATAGTCCCTGCCCGCAAATTTAACCCAAAGGTTGCCATTTCGGTATTT
+GGCAATGAAGACCATATGCCCAAAACTCAATCCTGAACCACAGCCCGCCCAAGACCTGCC
+TTCCGGAGGCGATTGCACCTCTCACCGCATGCTGTGGTCGAACCCGGCATTTAAAATCAT
+CGGCAATACGTCCTGTTCCGTCAAACCGGCGCCCCCATTTATTCCAAGCTTTATTCCACT
+CTCGCCCTGTTGGTTCGCGCTGCTGGATTGAACCTCTGAGTTTTACCAGATCAATCCACC
+GAAAGAATCCCCGGCCGAAACGGCGTTAGACTGTTCAGTACATGGCTGTCTGAATCAGAG
+GAGCCTGTATGAGTCATACATCAAGCGATCATTCGATTGCCTTTCCCCTGCGCCAAAAGT
+CAAAGCTACGCCATCTCGCTCAGGAGCTTCTCGCTAAAGCGGATATCAGAATTGACGGAG
+ACCGCCCCTGGGACATGCGTATCCTCAAGGAGGGCGTGCTTGAGCGCATCCTCGGGGAAG
+GCAGTCTCGGCCTTGGCGAGAGCTACATGGACGGCGAGTGGGACGCCGAGCGCGTGGATG
+AGTTTGTCTATCACCTGATACGGGCGCAACTGGATCGTGAGGTGCGCCCCTGGAACCTGA
+TCCTGCACGGTTTGCGCTATCGCCTGTTCAACATGCAGAGCCTCAGGCGAGCCTGGATGA
+TCGGGCAACGCCACTATGACCTCGGTAATGACCTCTATGAGGCGATGCTGGATCCACTGA
+TGACCTACTCATGCGGTTACTGGAAGACCGCCACCCATCTGGCAGCCGCACAGGAAGCCA
+AGCTGGAACTGATCTGCCGGAAACTGCAGTTGAAACCCGGGATGCGCCTGCTGGATATCG
+GTTGCGGCTGGGGCAGCCTCATGGCGTATGCGGCGCAGCACTATGGCGTCGAGTGTGTCG
+GCGTCACCGTTTCGGAGGAGCAGGTGAAGTGGGCGAGGCACCAGTACAAAGGGTTACCGG
+TCGAGTTCCGCCTGCAAGATTACCGAACGCTCGACGAGCAATTTGACTGCATCGCCAGTG
+TCGGTATGTTCGAGCACGTCGGGCACAAGAACTATCGGGAGTTCATGCAGGTGGCCCACC
+GCTGCCTGGATGATGGGGGCCTGTTTCTGTTGCACAGTATTGGCAATAACAGCCGCGACT
+CCGGTAGCGACCCCTGGATCGACAAATACATCTTTCCCAACGGCGAACTCCCATCCGTGG
+GACAGATCGGCGATGCCGCGGACGATCTGTTCGTGATCGAGGATCTGCACAATTTCGGCG
+CCGACTACGACAAAACCCTGATGGCCTGGCACGCAAACTTTGAAGCCGCCTGGCCCAAAC
+TCGCCTACCTGGGCGAACGCTTCCGGCGCATGTGGACGTACTACCTGCTTTCCTGTGCCG
+GCACATTCAGAGCGAGGGACATCCAGCTGTGGCAGTGGGTACTCTCCAAGCGCGGCGTCC
+AGTCCGGGTATATTCGTCCGTACTTCTGAACCGGGCCGCATTTATCAAGTGTCCCGTCTG
+ATCTGGCGGTAGTATGATTAAAAACGTACACCGCCATTACCTCGGGCACCGACGCCTTCA
+AGTTCAGCGTTTTTGCATCAGCAGCCCTTACTGAACTCGCCGGATCAAGACAAGCTCTTA
+CCGGGAGACCATCCAATGCAAACGCTCAATATCCCCAGCCTTGCCACAGTCACCGCCATT
+ACACTTTTGACCACCGCCTGCGCAAACAATCCAACGCCGGAAACACTTCAATCCAGGGGA
+TTGCACCCTTTGGATACGACCCAGCTTCATCAGCTCTATAGCAAAACGCTTCAGTTCGAT
+TGGCGAAACGCTCGCAGCCGGTCAGGTTCGGGCGAATACCAACCCAATGGTGAGATTTCC
+ATCGAATGGAGCGGCGAATCCTTTAATGGCAAATGGCGAATCCTGAATAACCATTTCTGC
+GCCACCTATGCTTCGATTCATAACGGGCAGGAACAGTGTTACATGGTCTACCAGACAGGC
+GCCAGGAGATACGTGGCGTTCCTGAACGGCGATTATTCCTATAGTTTCAATGTCAAGAAG
+GTTAAATAGCTGGTGGTTTAGCGTTTACAGGGGATTTCTCTGAGACTCAACCAAGCATAT
+TTAAAGCACCGGCCGGGCACGCCGCCATAAAACACGCATCGGGACAGGGGGAGGGGACCT
+AACAGGCTCTGCCCCGCCCACACTACTTCTTGATGAAGTCCCCAGAACCCGCTGGCGATA
+ACGTCTCTGTAGGATATCGATAGATGTTGGGCCCGTTACGAAGTTAAAAAATCTCTGGCC
+TTAGCAATGTAAGAGACTTCTCTACCCGGGGCCGACAATTCCGCTTCAGATAAGCCTAGA
+TATCGACCTTTAATATCGAAAACCGATTTTATTGCTGCTCCAAAATTTAGAGTAGCTACA
+CTGGCTACAATTTCTGGAGTGGAAGATATAAGGGTTGATAGTATCCCTTGACGAAATTTC
+TTATGTTGGATTTCCATATACTTTCTGTATTCATATAAAAGATGCTCTAGCTCCTCCTGT
+ATTTCTCTCGGCGATTGACCAGCAGACGATCTATCTTTTAACCAAATTCTAAGAGCGCGC
+AATTTAGCAACAGTTTCTTCTTCATTCCTAAACTGAATTAAATCTTCCCAAGGGATGTTC
+TCTGGAGGCATAGGAATATTGTTAATTGTAATTTCAAGTGCGTTAAGCTCATTCCCTTGG
+GTATTAAGATTGACCGCCTCTGCATGGGCTACAACTGGTTTATCGTTATACATTAGCCTG
+CTTGATAAATGCCTGATGAGGCGATCGGCGTGAGCTTCATTTTCGGCTTGATCTGGCACT
+CCCGTTCCCACCTGGAATGGTAAAAGAAGGTCACAGTCCTTTTTCATTTCCTCCATCGGG
+TTCCATGTAGTTCCGTCTGCTCTACCAAAGCTAATAAGATTGGGAATATCCAAGCCACAT
+AAAAGTGCAACCCCACGCTCTCTAAGGTATCGAAGTTCTGATGAATAACGCTGATTATCT
+TCTTTATTGAATGTGCGCCTCGACAACTTCCAAATCAGAATGTGGTCAAAGAACAACGCC
+ATTCTTTGAGCTTCCGCTGTATCCAAAACCAGATCCATTGGTGCCATTATTGCTCTACTG
+AGCATCAGTATGATCTCCTTATAGCCTACCGCGAAATTCAGCGGCACGCTTTAGCACGTC
+CGGTGGAGTGGCCGTGAGCCACGGAACAAATTGGAATGCATGGTTAGGTTGCGGCTTTGG
+CACATAAACCAAGCCAACGGTGAACTGTGGTTTGCCCTCCACCTCATCCATTCGTCTGGT
+AAGCACCAGATCACTGGCACCTTCCCTTTCGGTATAAAGATCCACAAGCACATCCCAATA
+AGACCACATCCATTGCACGCATGATGTACTCCATGTTTCCTCAGGCAGCTCCACAAGAGT
+CTCACCATAACCAGCAATATAGTCTTGGATATGCGCAGCAACATCAGGCGGAACCGGAGA
+CACGCCCTCAATTAGCTGGCTTAATTGATAGTCACCTCTCACGAACGCGCTGACGACTTT
+GCGCAGCATCGGACGACACGAAGCGGCGATTGGGTGCGCTGCCTCTTCATCTTTTACTGC
+AACTGGTAGGTCTTGCATCAGTTATGATTGCCTAACAGGTAATTCACCGTAAACTTACAC
+ATATCACTCACGTCCGCCATCCCCACCCGCATGCAAACTTCATAACAACCAACCCATTGT
+TTCAATTGACTTAATCCAAGTTAAATCGACCAATCCATCCGGGAAACTCCGAGGCGTGAA
+ACATTCCACACGTGTTTCACGGACACATCTCCAACTTCACCACATATTCAATTCCCGGGC
+AAACGCAGGGTCGTCCACTCTTTGCATGGCATCTTCGCCACTGGATAGTCGACAGCGTTC
+GGTGATCCACAGCACAGCCATCGCGATGGTGCGAATTGCATTAGGGATGAGGGATTGTGG
+CTCAGGAGGCTGGTCGCTTCAGGCGCGCGCCCGTGCCGGGCGCACAAAAAAAACCCCGCG
+GGAGCGGGGTTAAGGCTAGCGCTGTCTTGGAGGGAGCAAATAACAATCAGAGAGCACAGA
+ACAGGGATCTCTCATTGCTCCACCGATCCCTGCCATTGTTATTCTACAGATCAGGCCTTA
+CCTCCCAGTGGCCGCAGAATTACGTTTAGGTAATTGCCACGTTTCCGGTTTGAAGTGGCT
+CATCCCCAGTGCCAGCCAGGTATGCGGGTGTTAGGTTGTGCACTCTATTTTTTGCCCTTA
+ATATTCCGCCATTACTCAAAATGCCCTGGATAGACAAGCCCTTACGTATCCGCGCTATCC
+GGTGGCCCGGCCTTGAGGTGGTGTCAGGCCGTTTGCGGATCAATGAATGGAGAGCGACAC
+ATGAACACACAAAAGTTGATTAACCGGGCGCTGAGCGGTCTGGACGATCTGGGCTATCAG
+CTGGATTCCATGGGGATCACCAGCAAGGTTAACCGCCATAATGTGATTGCCTATGTGATG
+GCCGAGCAGAAACACTGGGAAGGCGAATACGACAGTCTGGTGGCGCGGATTGACCAACAG
+CGTTTTCGGGTCGAACAGATCGTGGGCCGTGTGGAAGGACTGGTGCGCGGCGGTGCTGAG
+TTTGCGCTGAAGCCGGTCAGCGGACTGCGCAGCCTGGTCAAAGCCTGAGTCAGCGGCTGG
+GGCTCAGGCCTACTGACGCCTGAGCCCTGCACGCGCCCCGACTAGCTGGCTGAACCTTCC
+GGTTCGGTTGTGCTGGTGGGTTTGATTTCCTTGCGCCTGTTGGGTTTCAGACGGGGGAAA
+CGCAGGGTCACTTTCAGCCCGGGGTTTTCCCTGCCGTCCGTATAGCGATCCGCCAGCTCA
+ATCCTGCCCTGGTGCATGTCCACCACGGCGCTGACCAGACTCAGCCCCAGGCCATTCCCC
+GGCTGCGAGCGGCTCTTGGCCACCCGGTAAAAGCGCTCGAATACCTTGTCCTTTTCTGAA
+TCCGGCACGCCGATGCCACTGTCTTCCACCTGGAAGATCGCATCATCCTCCTCCTGCGTC
+ACCAGCACCCGGATATTACCTTCAGGCGGGGTGTACTTGATGGCGTTATCGATCAGGTTG
+CTCACCACCTGAAAGATCAGATCCCGGTCGCCCTCGATGGTGACATCCTGCGGGATATCC
+AGCACAAATTCCTGTTCCTTGTCTTCCGCCAGGGCTTCGTACAGTTCACAGGCATCGTGC
+ACCAACGGGCCCAGCTGCACGGGCGACTTGTCGGCGGAGTGGCCGGTCATTTCCAGGCGG
+GCAATTCTTAACAGCGCATTGAAGGTCGCCAGAAGCTGATCCGTCTCGGCCACCGCGCGG
+GCAACCTGATCCCGGGCGGCGTCACCCTCCACCGTGAGCAGGGTATTTTCCAGCTGGGTG
+CGCAGGCGCGTCAGGGGGGTGCGCAGGTCGTGGGCGATGCTGTCGGAGACGTGGCGGATG
+CCTTCCATCAGGTGCACGATACGATCGAGCATCTGGTTGAGGTTGTCCGCCAGCTGATCG
+AAATCATCCCCGGTGCCCCGGGCAGGTATGCGCAGCGACAGATGCCCGTTCATGATCTTG
+CGGGCGGTCTGGTTAATCACCTCGATGCGCTTGGCGGTACTTCGGCTGATCATGAAGCCG
+CCGAACAGCGACAATGCCAGGGTAATACCCATCCCCCAATCGATGGCACGTTCGATCAGG
+TGCTTGAGGGTGGTGAGTTCCTGGACATCGCGGCCTACCAGCAAGCGGAGGCCGCCCTGA
+ACCTTGAACACCCGGGCCCTCGCAAGGTGGGGCTCGCCACGCCAGCCGACGGAGTCGTTC
+AGGGTAAAGTTGATCCAGCCGTTGCTGGCCTGCACATTCTGTGGCCAGGCGGACAGGTTG
+CCGGCGAGCTTGTCGTAATCGGAGGTGGTGAACAGGTACAGGGACTTGCCGTTGGGGTCC
+CGGGCAACCCGTTCACGCACGATGGCGATCAGTCCATTGATGCCGCGGCTGCGGTATTGC
+TCGGCCAGGCCCGTGATTTCCGCCTCGATGGTTTCATCGGTCTGGGCGGTCATGAACCCG
+GCCGTTCGCCAATAGATGAAGGCGAGCAAAAGGAACACGGACGTCGCGAAGACGACCATG
+TACAGCAGCGCAATTTGGAAGGTGGAGTTTCTAAGTTGGCTATGTATCTTCACGCAGCAT
+ATATCCAGCTCCCCTTACTGTCTGGAGCAGGGGTTTCTCGAAGCCTTTGTCTATCTTGGC
+TCGTAAACGGCTGATATGCACGTCAATCACGTTGGTTTGGGGGTCAAAATGATAATCCCA
+GACCTTTTCCAGCAACATGGTGCGGGTGACCACCTGGCCGGCGTGGCGCATCAGGTATTC
+CAGCAGACGGAATTCCCGGGGCTGCACATCGATGGACTGACCGGCGCGTTTGACGGTACG
+GGCCAACAGATCCATCTCCAGGTCGGCCACTTTGAGTACGGTTTCCGGTTCGTTGGAACT
+GCGGGTGCGGCGCACCAGCACTTCCATGCGCGCCAACAACTCGGTGAAGGAGAACGGTTT
+GGTCAGGTAATCATCGCCACCACCGCGCAGGCCTTCCACCCGGTCGTCCACATCGCCCAG
+GGCACTCAGGATCAGCACCGGGGTGGTGTTGCCGGTGGCGCGGACCGTCTTGATGATGTT
+GAGGCCGTCCATGCCCGGTAGCATGCGGTCGACAATCATCATGTCATAGTCTTCGCCCGC
+GGCCATCAACAGGCCGGTTTTGCCGTCGGCTGCATGGTCCACCACGTAATCCGATTCTTT
+CAGACCCTTGATCAAGTAGGCGGCCACATCCTGATCGTCTTCAATCACCAGTACGCGCAA
+CTTGGTTTCTCCTTGCGGTTCTTCCGTCGGTTCGTATTCCGATTGAGCTTCGGTCGCGGT
+TATACCAAACATTGTTCAAACCTTTCGCCAGTGATGGGTTTCACGGCAACACCTGCATCA
+AAATCAGCGGCCCTGTTGGGCAGACACAGACGTCTAATTTTTCGCCAACATGCATAAAAG
+ATTACTGTTTCCCTGGCGAATGGCCCAGTTACGATGTCGTAATGGCCCTTCTGGCACAAC
+AGTTGATGTCAAGCTTTTCGCTGAAAATGTAATCTAGAGCCATGATTTAAGACAAGATAG
+CCCGTCGAATGTTCCCACTTCCGGTACATATTCGGCGGCCACCCAGCCTTCATACCCCCA
+GGCATCCAGCTGCTCAAAAATTCGCCTAAAGTTAATCTCCCCGGTGCCGGGTTCATGACG
+ACCGGGATTGTCGGCAAACTGGATATGGCCAATTTGGGGCAGATTGGCACCCAGGGTTCG
+CAGCAGATCCCCTTCCATGATCTGCATGTGGTAGAGGTCGTATTGAAGCTTCAGATTGGG
+CAGGTTGAGGCGATCAATCAGGTCCAGGGCCAGTTTGGAGTGGTCGAGCAGGAAACCGGG
+GACATCGACCTTGCTGTTGATGGCCTCGATCAGCAATGTGATGTCCTGTTCCGCCAGCCG
+GGGCGCCGCCCAGCGCAGATTGGCTTCAAAGGTGGCCCAATAGGGTTCAGGCGGGGCCCC
+TGTGGGCAACGGACCAGCCAGGCAGTTGATCTGCCGGCACTTCATTATCTCCGCATAGCG
+CAGGGCACGTTCCACACCCTCCCGAAAGTCCGCTTCGCGTCCGGGCAGGCAGGCGATACC
+CCGTTCGCCGCCATCCCAATCACCCGCGGGCAGGTTGAACAGGACCTGCTGCAGCCCCTG
+GCCCTGCAGTTGGGCGGCGATCGCCTCAGGTGCCCAGGCATAGGGAAACTGGCACTCGAC
+CGCCCGGAAACCGGCCCTGGCGGCCTGCTCGAAGCGTTCAAGGAAGGGGACTTCGTTGAA
+CAGCAGACTGAGATTGGCAGCAAGTCGCGGCATGGTGTTGATCAGCGCTCCTGACCATCA
+GACGGGTCACTCATACGGGTTTGATTGAGGTGTTCCAGTTGCAGCAGCAAGGCGCTGTGA
+TCACATTCCCCCTCGCCCAGCGCAATCAGGGCGCGGTAACTCTGAAAAGCCTGCTGGGCC
+AGAGGCAGCGTGAGATCTTCGGCACGGGCCTGGTCAAGAATCATGCGCATGTCCTTGAGC
+TGGATACGCGAGGGCGCGCCGGGCTCAAAATCGCGCGCCAGCATCCGCTGTCCGTGCAGC
+TCCAGGATGCGACTGCCTGCGAAGCCGCCCAATAAAGCCTCCCGTACCGCTTCCGGGTCG
+GCCCCGCCCTTGGCGGCAAGTAACAGTGCCTCGGAGACCGCACCAATGGTGATGCCGACA
+ATCGCCTGATTCGCCAACTTGGCCAGCTGGCCGCTACCGGCAGGGCCGATATGCGTGACC
+CGCCCCAGTGTTTCCAGCAAGGGACGCACGGCCTCCAGGTCTTCATGACTACCGCCAGCC
+ATAATGGACAACGTCGCCTGTTCGGCGCCCACCGTGCCCCCGGAGACAGGGGCATCGATG
+TAGCCCACCCCCCTTGCCTTCAGTCTCCCTGCATGGGACTTGGCCATCTCCGGGGCGATG
+GAACTCATATCGAGAAAAACCGCGCCCGGCTGGATCGCCTCGGCCACTCCCTGCTCAACC
+AGTACCTGCTGCACGGCGTCGCCGTTCTCCAGCATGGTGATGATGCGGTCCGCCTGAGCC
+ACGGCCTGGGCAGCGGATTCAGCCACCCCGGCCTGGCCGGCCAGCGCACGGGCCTTTTCC
+GGCGAACGGTTCCAGACGGTCACCGGATAGCCGGCATTGATCAGGTTGGTGGCCATGGGG
+CGGCCCATCAGGCCAATGCCCAGGAAGGCGATCCTTGGCAGGTCGGTCATGCGATGCGGC
+CTCGCAGTCACAGTTTCAGGGAGAGGGATAGCTTAAACAAAAAGGGCCGCCCGAAGGCAG
+CCCTTTTCGACATCCTGCTTGCCGAAGACACATCAGGCGATGGATTCTTCACCCATCATC
+TTGCGGATCTTCTTCATGGCATTCTTTTCCAGCTGGCGGATACGCTCAGCGGAAACGCCG
+TATTTGTCTGCCAGCTCGTGCAGGGTCGACTTGCTTTCCGACAGCCAGCGCTCGCGCAGG
+ATGTCCTGGCTGCGCTCGTCCAGCGAATCCATGGCCTCCAGCAGACGGCTGTTGGAATCT
+TCAGTCCAGTCGGCCGCTTCCAGTTGCTGGGCGGGGTCGTAACGCCGGTCTTCGAGATAG
+TAGGCCGGTGCCTGCCAGGCGTTGTCGTCGTCATCATCCGTCGGGGCATCGAACGCGGTG
+TCCTGGGCGGCCAGACGCCCTTCCATCTCCCGCACGACCCGGGGCTCAACGCCCAGGTCT
+GCCGCCACGGCGGTGACTTCGTCGTTGTTGAGCCAGGCCAGCCGCTTCTTGGCGCTGCGC
+AGATTGAAGAACAGCTTGCGCTGGGCCTTGGTGGTGGCCACTTTGACGATACGCCAGTTG
+CGCAGAATAAACTCGTGAATTTCCGCCTTGATCCAGTGCACCGCAAACGACACCAGGCGC
+ACACCATAATCAGGGTTGAAGCGCTTGACCGCTTTCATCAGCCCCACGTTACCTTCCTGG
+ATCAGATCTGCCTGCGCCAGTCCGTACCCGGAATAACTGCGGGCAATATGGACGACAAAA
+CGCAGGTGTGAAAGCACCAGACGACGCGCGGCTTCCAGATCGTTGTCCTGCTGCAAACGC
+GCTGCCAGCTCCCGCTCTTCTTCCACCGTGAGCATGGGAATCGCGTTAACTCCCTGAATA
+TACGCCTGAACATTGGCGCCAGGGATCAGCTTGTCCATGACTTGAAGACTGGTACCCATG
+CGTAACCTCCGCAATATTGGACCGTATAAGATAGCACTTGGCTCTCAAGACATCCAGCTC
+GAACAAAAGTTCCCTTTAATGCCCGCTTTTCATTAAACATCAATAGCTTAAGCGTGAGTA
+GGGAGATCGCCGGAAACCGAAGTGCTGTTTAACCACTGGTATGAGGCTAGTTCAGACACC
+CTTCCAACTTCAATACGCGCATGCCACTACAGTGGATGAATCCATCAGAAGTGGGGATGA
+ATCGGTCAAATACAAGCCGATTGATGAAAGACAGGCGCCTCAACGCGGCTCAATGGCATC
+CAGGTGACGTTTCACCGCCAGCCATGACCCCATCCAGCCCAGCAGTACCCCGACCATGAT
+CACCAGCAGGAAATCGCCAAAACCGGCACCCTGCAACTGGAAATGGCTGCCATAGAGGCT
+CGCCAGCCGATTGACCGGGCCATCCAGCCAGGCTTCAAACAGTGCCACCAGGATAATCGC
+CACAATACTGCCACCGAGCCCATACCAGGCCCCGGTGTAGAGGAACGGGCGACGCACGAA
+GGCATCGGTGCCTCCCACCAACTTGGCGACCACGATTTCATCCCGGCGGTTTTCGATGGC
+CAGACGGATGGTATTGCCCACCACCAGCAGCACGGCCAGTGCCAGTAGGACACCCAGGGC
+CCAGACCGCGTTCACCACCAGGCCGATCATGGCCCGCAAGCGCTTGAGCCAGGCCAGGTC
+CACCTGAACCTCGGCCACCTGGGGCAGCTGCTTCAGGGACTGGCTCAGGGATTGAACTGC
+ACCGGGGTCCTGCAGCGCGGGTGCAACGATCAGGGTATTGGGCAGCGGGTTGTCATTCAG
+GTAGTCGAAGGCGGCACTCAGGCCCGAATCCTTGCGCAGCTGGGCCAGTGCCTGCTTCCG
+GGTCACCAGCTGCACATCGCGCACGTCGCCACGACTGCGAAGCTTGCCCTGCAGGTTCAT
+GGCCGCGGTTTCGTCCACGTTCTGTTTCAGGTACAGGTTGATGCGACTGGAATCCGACCA
+GCCTTCCCCCAGGGACTGGGCACTGGCCAGCAGCAACATCAGGCCCAGGGGCAGCGCCAG
+CGCCACGCCCATGACCAGCCAGGTCATCAGACTGCCGATCGGGTTGCGCAGCAGGCGAAT
+CAGGCTGTCGCGGGCGATCTTGCGATGATGGGAGGCATAGGCGTCGAGAAGTTCCCGTGT
+GGGATTCTCTGCGACGCCAGCGCCGCGCCGGCCACTTTTTTCCCGGGATTCATCCACCAA
+GTTTCACCTCAACCATCCAGCTTCACCTTAACCATAAAGCGCTTCCTCATCCGGCATACG
+GTCGCCCTGTGCCAGCCGCCCGCCATCCAGGGTGATCACCCGGTGACCCAGATGGCGAAT
+CAGGGAAATATCGTGACTGGCCACCAGCACCGTAACGCCCACCTGATTGAAGGCTTCGAA
+CAGATGCATGATGGAAGCGGACAGTTCCGGATCCAGGTTACCGGTGGGCTCGTCCGCGAG
+GAGCAGCGGCGGTTTGTTGACCACGGCGCGGGCGATACCCACCCGCTGCTGCTCGCCGCC
+GGACAGTTCCATGGGATTCATCCGCTCCTTGCTGAGCAGCCCCACCTTATCCAGCGCCGC
+CCGCACCCGCCGGCCCACTTCCCGGGGCGCGATGCCCATCACTTCGAGTGGCAGGGCGAC
+GTTATCGTAAACCGTGCGGTCAAACAGGAGCTGGTGATTCTGGAACACCACGCCGATGTG
+GCGGCGGATGTAGGGAATGCGGCGGCGGGGCAGTTTATCCAGCACCTGGCCGCCAATCAC
+CACCTGACCTTCGCTGGCCCGCTCCATCAGCATGATCAGCTTGAGCAGCGTGCTCTTGCC
+GGCACCGGAGTGGCCTGTCAGAAAGGCCATTTCGCCGCGTTCGAGCGCGAAGCTGACATC
+CCGCAGGGCGACGTGTCCACCTTCATACCGCTTGGTTACATGCTCAAACCGGATCATCGC
+TACTGCACTCTTGAAAAAAATCAGGCTGTGAAAAGGATCAGGCCGGCTCGTCAAACAGGG
+CTTCGACGAACTCTTCAGCCTGGAACGGGCGCAAGTCACCCACCTGTTCGCCCACACCGA
+TATAACGGATGGGCAGCTTGAGCTGACGGGCGATCGCGAAAATGATGCCGCCCTTGGCGG
+TGCCATCCAGCTTGGTGAGGGTAATCCCGGAGACACCCACCGCCTGCTGGAAGATCTGGG
+CCTGGCTCAGCGCGTTCTGACCGGTGCCCGCGTCCAGAACCAGCATCACTTCGTGCGGCG
+CCTCAGGGTCGAGCTTCTTCATTACCCGAACCACTTTCTCCAGCTCGGACATGAGGTTTT
+CCTTATTCTGCAGGCGACCCGCCGTATCGGCGATCACCACGTCGAAACCCCGGGCCTGGG
+CCGACTGCACCGCGTCGTAGATAACCGAAGCGCTGTCCGAGCCGGTCTGCTGGGCAATCA
+CCGGCACGTTGTTGCGCTCACCCCAGACCTGGAGCTGTTCCACCGCGGCGGCCCGGAAAG
+TATCGCCAGCGGCCAGCATGACACGCTTGCCCTGATCCTGGAACCGTCGCGCCAGTTTGC
+CGATGGTGGTGGTCTTGCCCACGCCGTTCACGCCCACCATCAGGATGACATAGGGCTTGT
+GCCCATCGTCGATATTCAGTGGGGCGGTGCTGGGCGCCAGGATGCCATGCAGTTCTTCAC
+GCAGCGCCTGCTTGAGCGCATCGCCGTCCTTGAGCTGCTTGCGCTCCAGCTTTTCGGTCA
+GCGTGTCGATGATCTCGGTGGTGGCGGTGACACCGACATCGGCGGTGAGCAGCAGGGTTT
+CGATGTCCTCCATCAGCTCGTCGTCGATGGCCTTCTGCCCTTTCAGCAGGTTACTGAGCC
+CCTCGGAGAAATTGCCACGGGTACGACCCAGCCCCTGCTTGATGCGGGCAAACCAGTTGA
+CCGGCGCTTCTTCAACTTCAGGCTCGGCAGCCGGAGTTTCAGCCGGAGGCGCCTCGACCG
+GCGGGGCTTCCTCGGCCACCGGTGGCGCGGGTGGGGCCTCGGCCTCCGGTTCGACCACTT
+CAGCTTCAGGCTCGGCCTTCGCCGGCTTCTCTTCAGCGGCGGGGGCTTCCGGCCTGGGCG
+GGGGTGCCTTCGCCTCGGGCACGGCTTCCCGCTGCTCAGGAGCAGCCGGCGGGCGCTCGG
+CGACCGGAGGTTGGGGTTTTTGCGGCGGCTTGCGCAGCCTCAGGCCGATATCGATAACAA
+AGGCCAGTACCAACAGGGCCAGTAGGCCAACGGAAATCCACTCTGCAGTCATTTACGCGC
+TTCCGGTTTCAAATTTGGAGGCTTGGCAGCGCCATGTGAGGCCGAATCAGGACGGGCCAG
+AAAAATAAGGCGCCAACGCCGGAGAAACGCCGTATTCTACCGGGCGGTTTGTGGGGCGTC
+CAAACCCCCGCTAACATAGCGACATCTTCAAGGAGTCCATTGATGCCCCCAACCCGTCGT
+TCCCCGCCCAGACAGCAGCGCGTCACCGCAAAAAAAGCGGGCGGCCTGTCGCGGCTAAGG
+ATCATTGGGGGCCAGTGGCGCAGCCGCCAGGTGCCGTTTCCGCCGGTGGAAGGCCTGCGG
+CCGACGCCCGACCGGGTACGGGAAACCCTGTTCAACTGGCTGGCTGGCGATATCCCCGCC
+AGCCGCTGCCTGGACCTGTTTGCCGGCAGCGGCGCCCTGGGGCTGGAAGCCCTGTCACGG
+GAGGCACGGCACCTGGTTTTCGTCGACACCGCTTCCGAGGTAATCCGCACACTGCGGGAA
+AATCTGCGCACCCTGGGCTGCCAGCAGGCCGACGTCTTCCAGCAGGACGCCGAACAATTC
+CTGCAACGACCACCGGCCACGCCTTACGATGTCATCTTTCTTGACCCGCCGTTCCGTCAA
+GGCTGGCTGGACAAAGTGATCCCGCTGCTGCAGCAACCGGGCTGGCTGAAACCGGGCGGC
+TGGGTCTATGTCGAACATGAAGCGGAGCTGAACGCCAGGCCATGGCCCTCCCACTGGCAT
+GAACACCGTCAGAAGGAAGCCGGTCAGGTGGTGTATCGACTGTTTCACGTGGCCGATGCC
+CTCAAGGACACAGCTGAAGGTGTGGAACGGGCATCCTGAAAACAGAAGCCGACAACCATT
+GACCGGCTCATCACAATCGGTTTAAAACAACCGGTTTAATACAATCGATTTAATACGATT
+AATTTAAAACGGCCGATTTAATGCGATCGATTCAATAAGGTCGACTCAATGCAGTCGATC
+AATCACAACAGGGGGATATCCAATGCACCTTTGGCGCATTGTGTGGGTACTGATCGTTCT
+TGTGGCCGTCCTTGGCGGCGTTTATTTCCTGTTTCCCGGCACGATTGTCAACGCCGACAA
+AAGTTTCGAGCTCTGGCGGGCCGGCCTGGCTGTCCACGACATCAACGTCGACGACCAGCA
+CATTCACTATGTGGATAGCGGCGGCCAGGGCCGGGTGGTGCTGATGCTGCATGGCTTTGC
+GGCGGATTATTACAGTTGGCCGCGCATGGCGCGTTATATGAAGGCCGGCTACCGCGTGAT
+CGCGCCGGATTTGCCGGGTTTCGGTCAGAGTTCACGCATCGCTGCGGACAACTACGGTAT
+CAGCCAGCAGGCCCAGCGGATGCATGACTTCCTCAGGGCGCTGAATGTCGACAAAGTGGA
+CATCGTCGGCAACTCCATGGGTGGCTGGATCGCAGCAGAGTTCGCCGCCCGCTTCCCCGC
+CCAGACCCGTACCCTGACGCTGATCGATACCGGCGGCATTACCGCGCCTCACCCCAGCCC
+CTTCATGCAGGCGGTGGAAAAGGGCGAGAATCCGCTGGTGGTCCACAACCGGGCCCAGTT
+CAATCACCTGCTGACCATCGTATTCCACCACCAGCCGTTTATTCCCGGTCCGCTCAAGGG
+CTACTTCGCAAAACAGGCGGTTGAGCACGCCGCGTTCAATGAGAAGGTCTTCAAGGATCT
+TACGGATGACTACGTGGATCTGGAACCGCTACTGCCCAAGCTGACCATGCCTACCCTGGT
+CATGTGGGGCCGCTATGACCAGATCCTCGATCCCAGCTGCGTGGAGGTGCTCAAAGCCGG
+GCTGCCGAACGCCACCATCAAATGGTTCGATACCGGGCACGCACCAATGCTGGAGCAACC
+GAAGGCGAGTGCGGAGGTCCTGAAGGCCTTTTTGCAGGCGAATCGTGGGGATTAGGTAGG
+TGAGGAGTGAGGGGTGAGGCCGCGCGCTTTGCGCGCTGGTGAGGGGTGAGGAAATCTCTA
+AAACCTCCTAACTCCTAACCGCCTTACCCCTAACCCACCCACAAAAAAGGGCACCCATTC
+CTGAGTGCCCCTCTTCCAGTTTCCTACCCGGTTCAGGCGGTCTGCGGCCGCAGCGAGTAG
+CTGCGCAGCGTGGCGGCAAACTCTTCCAGATAGCGCACACCACTTTCTTCTGCCTGATGG
+CACCATTCGACCAGCGCGTTCAGCTTGTCCTGCGGGCGCATGCCCGGACGGCGCTGCCAG
+ATCGCCTGCAGTTCATGGCTCTTTTCATAAATGAGCCGGACCACCGCACTGTTCTGAAGC
+ACCTGTTCCAGGGACTGACGCTCCTGCGGCTTGATCAGGCTTTCCTCACGGAATACCAGC
+TTGCGCACGCGGCGGTACAGGGGCTTGATGTCCTTCTCCACCACGCTGCGTTGCTGACGC
+AGGACCGGCTCCAGCACGCGCTTACGGTACAGGCGCATGACATGGAAACGGTTGTTGGCG
+ATGGCCTGTACGGTTTCCACATCCATGTCCATCTTGCCCGGAATCTGGTGGGCGATGGGT
+CGGTAGCCTTTGGGCTTGGCCAGACCAAACAGCTGCAGCAGGCGGATGTAGCCCCAGCCG
+ATATCCAGCTCCCACCAACGGCGTGACAGCTTGGACGAATTGGGGAAGGTGTGATGGTTG
+TTGTGCAGCTCTTCACCGCCAATCAGGATGCCCCAGGGGACGATGTTGCGGGCGTTGTCG
+GCACACTCGAAGTTACGATAGCCCCAGAAATGGCCGATACCGTTGATAACACCGGCAGCA
+AAGATAGGGATCCACATCATCTGTACAGCCCAGATCCAGATGCCGTTCACACCGAACAAC
+AGCAGATCGATCACCGCCATCAGGGCAACACCGCCCAGGCGATAGCGGGAATAGACATTG
+CGCTCAACCCAGTCTTCAGGCGTGCGCTGTCCATACCGTTCACAGATTTCATCGGAGATT
+GCGGCGCGATAGTTTTCGGCACCCCGCCACATGATTTCACTGAACCCCTTCACCACGGGG
+CTGTGGGGATCTTCTTCAGTTTCGCAGGTAGCGTGGTGCTTGCGATGGATTGCCGTCCAC
+TCTTTGGTCACCATGCCGGTCGTCAGCCACAGCCACAACCGGAAAAAATGCGCCACCACC
+GGGTTCAGATCCACAGAATTGTGGGCCGAGTGCCGATGGAGGTAGACCGTCACGCTGACG
+ATAGTGACATGCGTCATCGCCAGGGCGATCAGAATCAGTTGCCACGCGGGCAGATGATGG
+AAAAGGCCGTAAAGCCACATTGAGCAGTTCCTCACTTTTTCACTGCACCCCGTTGGAGAC
+CGGGTGCATATTATTGCCGATGGTAGCTTACACCTGTACGCCGAACAAGGCGTAGATACC
+GCAAAATTACAAAAAGGCACAGCAGTACTGTTCTCAGTTGCAAGCCCCGTCACACGGCGT
+TTCCGGAGGCCATTTGATGGAGAACATCAACCGCATCACCACCGGGAATTGTTCTATCGA
+CCCCATTGACAACACCGAACCGCAGGCGTATCAATTGCGCGTTTTTTAACCCGGGACTGC
+CATTGTGCCTGAATTACCCGAAGTTGAAACCACCCGGCGCGGTATTGAGCCGCATTTGGT
+CGGTCATACCGTCACACAGCTGCAGGTACGTGAATCCCGTTTGCGCTGGCCCGTTCCCGA
+CAAACTGGATCAGATGCTGCCGGGCCAGAAGGTCGGCCAGGTCGCACGTCGCGGTAAATA
+TCTGCTGGTCCACCTGGAGCGGGGCACATTACTGGTTCACCTGGGCATGTCCGGCAGCCT
+GCGCGTGGTCACCCGTGCCGAAGCCCTGCGCAAGCACGACCATATCGACCTGACCACTGA
+CGCCGGCACCATCATCCGGTTCAATGACCCGCGACGCTTCGGTGCCTGGCTCTGGACCGA
+AGACTGGCAACACCACCCCCTGCTAGCTTCCCTGGGACCAGAGCCGCTTTCGCCTGCCTT
+CAGCGGCCACTACCTGCATCGCCAGTCCCGCAGGCGCAAAGCGCCGATCAAGCAATTCAT
+TATGGACAGTCACATGGTAGTGGGCGTCGGCAACATCTACGCCAATGAGGCCCTTTTTAT
+CAGCGGCATCGACCCGCGCAGGCCCGCCGGCCGGATCAGCGCCGCCCGCATGGAGGCATT
+GGTCCTGGCCATTCAGCAGGTGCTGGAGAATGCCATTGCGGTAGGGGGCACTACTCTGCG
+GGATTTCGTCAACAGCGAGGGGCAGCCGGGCTATTTCCGCCAATCCCTGCAGGTTTACGG
+ACGCGAGGGCCAGCCCTGTCGCCGTTGCGGCAAACCATTACGTCAACTGAGGCTGGGTCA
+GCGCAGCACGGTTTTCTGTGGTCATTGCCAACGCTAGCGGCCGGATGGTCAATCAAATTG
+ATGCCCAACAAGGCAGGACACCAAAATACAACAAAAATCCTTTTGAAATTGACCAAATAT
+GGACCATATTTAAAGAAGTACTAAAAATGTAATCCGGATTCCGGCGCTGGTAAGTTACAC
+TGGCGCGCGCCGAGGACAGCCACAGTTAAACAGGGAAAGGACCGGAACAAAACGCTTTTC
+CATTAACGGACTCAAAGGCTTCCTAACACAATTCGCAACGAGCAACTATACTCGTTTCGA
+GCTACCCGAGATTCTTGGCCGAACCTGGACATCACAACGACGTCAGGTTGGCTTATGAGT
+GGTTAAAAGCAGGAGAAAACCATGCGGCCCAAATTGTCCCATGCCTTGGCAGCCATCCTC
+GCTGCCTGCGTCATGAGCCTGGCACCGATGACCCAGGCGGAAACCACCCAATCCACCCCT
+TCGGCCCTGGCCATGACCGGTGATGCGCTTTTCGCCCGTCCGGCACTGCTAGCCATGACG
+CTGGTCGGAAGTGCGGTCTACGTGGTGTCCCTGCCGTTTTCGCTTCTGGGTGGTAACGCC
+TCCGAAGCCGGCAAGGTGCTGGTGGTGGATCCGGCCAAGGCAACCTTTACCCGCTGTCTG
+GGCTGCACCATGAACCAGAATCGGCAGAACGAGCAGAAAAATCAGAATCAGGTCGCCACG
+GCGGACAATACGGACACCACCAGCAACTGAGCAGGTGCCTGTACCCGACCTGGACGAACC
+GGCACCAATGGTGCCCGGAATGACCGTTTAAACATCAAGGCCAGCCTCTGTGCTGGCCTG
+TTTTTATTTTTTCGCTGATAGCCCCATGCTGAACTGGTCCCAAATCGACACCGCTTTGCT
+GGATATGGACGGGACTCTGCTCGACCTGCATTTCGACAGCCATTTCTGGCTGGAGCATTT
+GCCCCGCCGTTATGCCGAACTCAAACACCTGGATCCGGAGCATGCCCGCCAATCACTGCT
+GAGCAAGATTGAACAGTTGCGCGGCAAGCTGGACTGGTACTGCATCGATTTCTGGAGCGA
+CCTGCTGGATCTGGATGTGGTGGCGCTCAAGCGGGAAACACGGGATCGCATTGCCTGGCG
+CCCCCACAGCAAGGCCTTCCTGGAGCGCCTGCGCGCCTGTGGTATCCGGCGGGTGCTGGT
+GACCAACTCCCACCCCGACGGCCTCAACCTGAAAATCGAGACGACCGGCATTGACCAGCA
+CCTGGACCGTCTGTTTTCCAGCCACAGCTTTGGCCAGCCCAAGGAAGGCCCCGATTTCTG
+GGAGCAGCTGGCTCAACAGGAGCCGTTCGACCCCGAGCGCACCCTGCTGATCGACGACAG
+CCTGCCTGTGCTGGAAAGCGCCCGCCGTTACGGCATTCGTCACTTACTGGCCATTCTCAG
+CCCCGATAGCCAACAACCGCCCCGTCAACCGTCCCATCATCCCTGCGTCCATGATTTCGA
+TGAACTGTTCCAGTCACTGGACCAGTTCGCCCACCAGAAAAACCGAATCGACGGTCTCAG
+CGACTGAAAAACCGGCACGGCAGGGAAATTTCTTCGGCACGCCGGCCTTCGGCCCGAACC
+CCAGGCGCGGTATAATGGGCCAAGGCCAACATGACGGAGCACCATGACAGCCCATTCAGA
+CCAGCAACAGCAAGAGGCGCGTATCCGGCTCGACAAGTGGCTTTGGGCCGCGCGCTTTTA
+CAAAACGCGCACCCTGGCCAAGGAAGCGATCGAAGGTGGCAAGGTCCATTACAATGGCCA
+GCGCACCAAACCCGGTAAAGTGGTGGAACTCGGAGCCCGCATCCGGCTCAAGCAGGGCTG
+GGCGGAAAAGGAGGTCGTCATCCAGGGGCTGAGCGACCGGCGCGGCGGTGCTCCGCAGGC
+CCGCGAACTTTATCAGGAGACCGACGACAGCCAGCAGCGCCGGGAAGACGAGCACTGGCA
+GCGCAAGATGATGCAGGCGGCCCAGATGCCACCGGCGCGACGCCCCAACAAAAAGCAGCG
+CCGCGAGTTGCAGCGGCTGAAAAGCGGACAGGGCTGAAGCAGAACCGGGCCCGCCCTCCA
+CCACCCGAACCCGACGACATTGCATTCAGGGGATCATGGCATGACCGGCCAAGACCAGTT
+ACAGCGTTTTCTGTTCGAAAATTCAAATATTCGCGGCAGCATTGTGCGGCTGGACGACAC
+CTTCCAGCAGGCAACCGGGCAACAGGACTATCCGACAGTGGTTCGCAATCTGGTCGGCCA
+GAGTCTCGCTGCCTGCGCACTGATGGGGGACAGCCTGAAATTCCAGGGCAGCCTGTCCCT
+TCAGGCCCAGGGGGAAGGCCCGTTGCGCCTGCTGGTAAGCGACAGCACCGACCAGCTCAC
+CTTGCGCGGCCTGGCACACTGGAACCCGGAAGCCGCCGAGGCCGAAACCCTGCCCGCGCT
+GATCGGTAACGGTCACCTCGTGATCACCATTACGCCGGATGCAGGCCAGCGCTATCAGGG
+CATCGTGCCGCTGGAGCAGGACACCCTGGCCGGTTGCCTGGAGGACTATTTCCGGCTCTC
+CGAGCAGCTGGCCACCTTTATGTGCCTGTTTGCGGACGAGAAGGGGGCCGCAGGCCTGTT
+GCTGCAACAGTTGCCGGGAGAGCTGGCCGGCCCCGACACTGACCTCTGGCCCCGCGCTAT
+CAAGCTCGCGCAGACCCTGACCACTGAAGAGGCCCTGCAACTGCCATCGGAGGAGCTGAT
+ACACCGCCTTTATCATCAGGAACAGGTGAGACTGTTCCCGGCCCGTGCAACCCGCTTTGG
+CTGCAGCTGCTCGCGCGAGCGCACGCGGCTGGCACTGGAATCCCTGGGCCAGGACGATTG
+CATGGCCCTGCTCGACGAGCAGGAGGTCATCGAGATCGACTGCCATTTCTGCGGCCAGCG
+CTACCGTTACGACCGGGCGGATGTCCGGGCGGTCTTCGGCGGTCCGCGTCTGCATTAGGG
+AGCCTCTGATTAAGCCCCTTTCAGGCAAAGCGTGATCCTCATCAGACGTTTTGCGATGGC
+CTCGAAGTCGAATTTTTTGACAGCCTCTGGCATAATGCGCGCCTGACCCGGCCGGACCGT
+TTTCCAGGCACCCGATTTTCAGACGCATCAAGACAGGGTTCCAGGAAGACAGAGCGCGCC
+TTTGCGAAGGCAAGGCAGTTCCGCCTGACGTCAATGAATTTTACGGCGCATGGTTGATCT
+CCGTGCGCCGGCATTGAATTTTGAGCCCGTGCTGCAGGTAGAGCGTTCGACACAGGGCGG
+TTGCAGGCATGAGAACCGCGCCATCTGGTTGAGCCCCTTTTTTTACCGCCCCGTCAACTT
+CGGCAGGCATTCCGAATGACGCTTCCCGCACCAGGCCGCTGTGGATTCCACCATTTAAAA
+TAGGGCGAGGTTGAGAGTGAGCAACACTTACACAGATCTGAGCTCAGCACGACTGGTCGA
+GCTGGCACTGGAGCGTAATGAAGGGAAACTGGCCGCCAATGGCGCACTGGTTGTCAACAC
+GGGCCGCCGCACCGGGCGTTCACCGATGGACCGCTTCATTGTTGAAGATCCCGCTACGGC
+CGAACTGATCCACTGGGGTCCGGTCAACCGGCCTTTCGATGCTGCCAAATTTGATGCACT
+CTGGGAACGGGTTGAAAGCCATCTGGAAGAGCGGGACCAGTTCGTGTCCTATGTCCACGT
+AGGCGCCGACCCGGAACATTACCTGCCGGTCAAGATGACCACCGAAACCGCCTGGCAGAA
+CCTGTTCGGCCGTAACCTGTTTATCCGCCCGGACAACTACAACCCCATCGACAAGGGCGA
+ATGGCAGATTCTCAACGCTGCCGGCTTCGTCTGCGAACCTGAGCGTGATGGCACCAACAG
+TGACGGCTGTGTGATTCTCAACTTCGCTGAGCGTAAGGTGCTGATCGCAGGCATGCGTTA
+TGCCGGTGAAATGAAAAAAGCCATGTTCTCCGTGCAGAACTTCCTGCTGCCCGAGCAGGA
+CGTGCTGCCGATGCACTGCTCCGCCAATGTCGGCGAAGACGGCGATACCTGCCTGTTCTT
+CGGCCTTTCCGGCACCGGCAAGACCACCCTGTCCGCCGATGAAGACCGCTATCTGATTGG
+TGATGACGAGCACGGCTGGGGTCGCGGCACCGTTTTCAACCTGGAAGGTGGCTGCTACGC
+CAAGTGCATCAACCTGAGCAAGAAAAACGAGCCGATCATCTGGGACGCGATCCGCTTTGG
+CGCCATTGTCGAAAATGTCGTCATCGACAACGACAGCCGCGAGCCGGATTACGACGACGT
+ATCCCTGACTGAGAACAGTCGCTGCGCCTACCCGCTGGAGCACGTCGAAAAGCGCGTGCT
+GGAAAATCGCGGGGGCGAGCCCCGCGCCGTGATCTTCCTGACCTGCGATATGACAGGCGT
+GCTGCCGCCCGTATCCATCCTCAACAAAGAAGGGGCGGCGTATCACTTCCTGAGCGGCTA
+CACCGCCCTGGTAGGCTCCACCGAGATGGGCTCCAGCGCCAAGCTGCGCAGTACCTTCTC
+CACCTGCTTTGGTGCGCCTTTCTTCCCCCGCCCGGCCGGCGTTTACGCCAACCTGCTGAT
+GAAGCGTATGGAAGAGTTTGGCAGCCGCGTCTACCTGGTCAACACCGGCTGGACCGGTGG
+CCCCTACGGCGTCGGCAAGCGTTTCAGCATCCCCACCACCCGGGCGATCATTCGCGGCAT
+TCAGACCGGCGCCCTGGAAAACGTCCAGACCCAGCACCTGGATGACCTGAACCTGGACGT
+CCCGGTGGAAGTGCCCGGTGTCGACAGTAACCTGCTGAACCCGAGAAACACCTGGCAGGA
+CAAGGAAGCCTATCACCACAAGGCGCAGGAGCTGATTGCCCAGTTCGTGGAAAACTTCAA
+GAAATTCGACGTATCCGATGCCATCGTCAATGCCGGACCGAAGTTGAAGGACTGAAGCAA
+AGACAGTCAGCGGCCGGTTGATTCAGCCGGCCTGCGAGCGAAAAGGGCGCCTCTTGGGGC
+GCCCTTTTTTATGAGGTGGTGAGGTGGTGAGGTGGTGAAAAAGTATGACTCAGCTCGTCT
+TACCCCTCACCAGCGCGCACCGCGCGCATCCCTAACCCCTCACCCGGTCTTATACTCACC
+GCGCATAGAACAATAGCGGCACAAAAGCCACGATCAGCAAAGCGCTCCCCATCACCAGCA
+GCGGCATCAGAACCCGTTCATGACGCTGATAGAAGCTACCACTCTCGCGATAGGACAGAT
+TCATCTCGCTCTCACCCACGACCTGCCGTGTCAGCAAGTGGTTCAATGCCACGGGCGGGC
+TCAGATACCCCAGCTCGAACGCCACCAGCGTCACCATCCAGAAGTGCACCGGTGCAATGC
+CACTCTGATACGCCAGGTCGGCAATGGTGGCACTTACCAGGATGACCGCACCAAAGGGGT
+CCATGATCATGCCCAGGATGACCAGGATCACCACCATCAGCATCATGGCGAGCCAGGGGC
+TGGGCAGCGCCTGTGGGAACAGGCTCATGACCTGTGAGCGCTCAATCACACCACCAATAC
+TGACCGACAGCCCAAACAGCAGCAGCAGGGCACCAATTTCCGCCGTGGTTTCAGAGGTGG
+CGGTGCGGAGGCTCTTTTCCAGACCCTGATGATCCACTTCACCACTGACTTTGTTGCGGT
+CGCCGCGAAAATGGACATGCTCATAGACCAGGATGCCCACCATGATAATCGGCAGGATGC
+GTGGTGCGGAGAACTCGTTCATCGTCACACCCAGCAGCAGCCAGTAGAAGAACACCACAC
+CGGCAATCACCAGGACGTAGGGAATCAGAGGCTTGAGGCGCATCACCATCTCCGGCAGCG
+CCTCGTTCATCGGCGCGACCTTGAAGCCTTTCTGGCGATTAACGACCAGAGAAGTAATCA
+GGAACAACGTCGATGTCAGCAAAAATACCCAGCCGCCCCAGTGGAACAGGGAGTCGGTGG
+TTACCTCCCGGTTGAGGTAGGCAATGACCACCACCAGCAGACAGGGGTTCAGGACCACGC
+CCAGCGAACCGGACATGGCGGTCGAGGCCAGGGCCAACTGGCGCCGGGCACCCGCCTTGC
+GCATTTCCGAGTAGATGACAGCGCCGGCGGCGATCACGAAAATACCCGAGGCACCGGTGT
+AGGCGGTCGGCACTGCCGCCACCATGACCGCGACCACAGCCAGCAGTTCGGGTGGCAGCT
+TGAGCGGGCGCAGTACATTGAAGACCAGACTCGCCAGCCGGGTCTGCTTGAGCATCATGC
+CTGCCCAGACATAAAGGCCCACATTCAGGAACTGGTCCGCCAGCTCCATCATCTTGTCCA
+GGTAGATGCCAATTCCCGCGGGACTACCGACAAACGCGAAGAACGTGCCGGAAATCAGGC
+ACATGGTGGTATAGAGCGGCACACACAGAAAGGCATGCCCCAGCGTGCCGCCTTCCTCGG
+CATCCTCCGGCACCCGGAACAGTTGCACCAGACTGACGATGGTCAGCAGCAGGAAACCGG
+CAATCCAGATGTCGTGGGAAATTTCCTGGCCCGTGGTCACCACGGCACCGGAGTTGTGAC
+TCATCTGCCGGTACATGAAGCTCGAGATCAGCAGCATGGTATTGGCGATGAACTGCATGA
+AATGAGAGACGATATGGTCCAGTCGCGTCTCCATCCCTCGCATGGCGATGTGGTGCCGGC
+TGAAGGTTGCCGTTGCGGCACAGACCAGCACCAGTAACGCCAGTATGTAACGTTGTGATG
+CCAGTCCAAACGCCACTACATCAGAGATGAATAACTCGACTGACCGGTAGACGCGCACCC
+CTTCGGTGATCCGCCCCTTGGTCGCATTGTAATCCGCGAACTGGGCCTCACAGGCCTGCT
+TGGCATTGATGACAGACTGGCGAACCGCTGCCGGATTAACCGGGCTTGAGCCCACCAGGC
+TGCCCAGCATGCTGTCCTGTTGAGCAGCCTGCGCGGCTATCTGCCTCTTGACCTGGGCGT
+CGACATTCACATTGGGGTTACAGTCCGGTTTGACCGGGTCGACCCGCAGCTTGTAATAGC
+CACTCCAGAGCACCTGCCCCAATTGCAGCGCCTTGTTGTGGATATCGCTGCTGGTGGTGA
+ACAGCACCACCGCCATCAGCAGGATGCACGCCGGCAGGGATGAAAACCATTCCCGGGCCG
+AGCGACCGCCTATCGTGCGCTTTTGCAAATACATGGAACTCTGTTCGATGGCTTCTGACA
+TGGCGCTATTCCGCAAAAAAGCCCATTGCCTGTCTGGCGGCAATGAGGCCTGGTTACTTC
+TTGTCCTGGACTGAGCGGGCGGTCCGAACCAAACTGGACCGCCCCCAATCCCTATTCCGC
+ATTTTGCGAGCACTCACCCCGACTGGGCTGAACCTTGCAGCGGATAATCTTCATCAGCTT
+GAGCGCCTTGGCGTCATATACACCTTTGTCACGCAGGCTGAGGCGGACCGACTGCAGCAT
+CTGGTCATAGGACGCGGTCTGCTTATCGGTGGGGTACATCCAGTACTTCTTCTTGATCTC
+GTCAGTCGCCTTGTTGATGATGCTGAAGGCCTGGTTGAGATGTTCACGGGCATACTCACG
+CACGTGATTGGCATAACCCTTGGGGAAACGCGACTTGTGCAGGATGATCTGGAAGTTCAT
+CTGCGCCAGCGGGTATTGCAGCACGCCACCATCGTGTGACAGCCCTTTGTAGAGCTCCAG
+GGGGGTATAGGCCACTGCCGGTGCGTAGGCCAGGTCCACGCTACCGTTGTTGAACAGGCC
+AGCGAAGCTGGCGGAGCTGGCACCGACAACGGAGGCACCCACGTGACGCACCATTGTCAG
+CGACGCCCTGTCGTACGACAGGGTGGCGATCTTCTTGCCCTGAAGCTTGTTCACGGTATC
+GATGTTGCGGTTACGGGTGAACAGGTAAACCGCGCCAGCCGGGAGAATCCCCGCCACTTC
+ATAGTCGCCGTTGGTCAGGAGTTTGGCCGCCTTGGGCTGATTCAGGGTGTCCATCAGCAC
+ACGCTCTTCCTTGTTGCTGGTGATGGCCCCCAGCGCTTCCAGCGTACCGGTAAACTTGTT
+GAATTCCCGCGCCCGGGTGCCGGTCAGCAGGACCGAATCACACTGGCCCCCCTTGAAGTC
+CTCAGCCGCGATCTTTTCATCGGTGTAAGCCCGCATCTGGAGGTCGACGCCCCAGTCCAG
+GGCCGCCGGTTTGGTGGACTTCATCAGATTGAACAGGGGGCCGTTGGCACCGACCGGATC
+GAAGACGCAAAAACTGCGCTTGGGCAGGGAGCCCGCGTTGGCGGCCGGCTGCAGCGCCAG
+CATGCCAGCCAGGGTCAGGGAGGCCAGGCTCCAGGTTTTCAGCGAAAAACGTTTTCCAGA
+CGGCTTCACAACAAATTTCTCCTCAACATTATCCTGTCTCTGTTTCTTCCTTGGCGCCGG
+GCCCGTTTCAGAACCCGGCGTTGTTTACATGACCGAATCCAGGTCGATCACTTCGCCGGA
+ACCCTTGGAGTCGTCCCAGAAGGTCCCCAGACCGCCGATCGGGGTCCGGTGCCCGGTATG
+CTCCACCCACATGCGGTCGGAAATGGACCGCAGATAGAGGGTGGAAAGCTTGTCGATCAT
+CTTCCAGCGCGGATCGGCCGGATATTTGGCTTCCTGGGCCTGCTGCTCCCGGATCAGTTT
+CTTCACCAGCTTGGTGTCGCCCTTGTTCCAGGCGGCAATCACGTGCAGCACGTAGGCCAG
+GCGAACCCGTGCCTTGTTGGCCTTCTTGTCGGACTCGTCCAGACGCTGGAAGGGGTTCTC
+GCCATCGGGCTTGGCGCCGGGAATCATGGACCACACGGTGGCGCGCAGTGCCATGGGCAC
+CCCCCACCATTTGTCGTCACTCAGGCAGCCGCTGGCCTGGGCCACGGTGGAACCGATGTT
+CTTGGGCACGCCCTCGTCGGAGGTGGACTGAATTTCGGCCGCCAGTGCCTGAACGCCGGC
+CAGCAGGCCTGCCATATAGATAAACTGGCCTTCGTCATTCTTGAAGGTCGGGCATTGACC
+GGTGGAAGGGTCACCGTAGTAGGCAACCAGGTGTTTCCAGGCGCTGTAGTAGCGATCAGC
+CGCCTCGATGTAGTGGCGCTTCTCGACGATCATGTCGTCTTCGGCGTTTTGCGGATGCTG
+GTTACGCAACTCCTTCATGTAGGCGAGCTCGGCGTTCCAGCCCTTCTCCTCGGCGCAGGT
+GCCGGCGGACATCTGCATCATCACGCCCAACTGATCCGGCTTGGCGGTCACCTGGCCAAA
+GGACATCAGCAAAGGCGTCAGAGCCTCGCTCATGGCACAGCTCATGCCCAGGTCATCACT
+GGACAGCACATAGGGGACCGCATGGGCCTTGGCATAACCCACCATGACCTCACCCGTGGT
+CTTGTACATCATGTTGTTGACCGCACTACAGCCGCCGAGACTGAACAGCAACAACAGGGA
+AAGGGCCTTGACCGCGCTACGCCCGTGAGAGAACAAAAATGCTGAGTGAGAGAGCCACCG
+CATGCTTACGTCATCCCTTATTTTTGTGTTTGCGTGTTTTTGTCCGGCAGCTCAATAGGA
+CCACCGAAACCACTGTTACATTAAGTAACTGTTGGTAACGCGTCGCATTATCTACGAGTT
+ACCAACAAAAATGTGAGACAGGCCCCACAAAGCGCTATTATCAAAAGAGGCTCAAAGCGC
+CTTTATATCAACGTGTTCAATCACAATGACCCATCCCAAAACCACGATGGAGGCAGACCT
+TGGAGAACAGCACCCAAAATGCCCTGCATAAGCCGGAACTCGCCGGGAAAATCGCCGACC
+AGACCCAGCTGACCCGTGCCCAGGCCCACGAGGTCATTACCGCTTTTACGGATCAGGTGT
+CCGCCGCCATGGCCCGTGGGGAAACCGTTGCGCTTGCCGGTTTCGGTTCCTTCAATGTGC
+GCGAACGCCAGGCCCGTACCGGTCGTAATCCACGTACCGGGGAGGCGCTGCAGATTCCGG
+CGCACAAAACCGTTGGTTTTCGTCCCGGCAAAGCCTTCAGGGAAGCCATCGAATAGGCTT
+CAGGGTGAGCCACACCCCTGTTTGGCCCCAAATGAATGGTGACTCAAAGTATCGGGGAGG
+CGGGTGGGAAGCGTTGGCATCAATGCCGCGAAAAACCGGCAGTGCGGCAAACCTCGTTAA
+CCGGCCGGCAATACGTTCTGGCGTGACTGCAATAACGGCGGGCGATTAAGAGGAATCAGT
+TCAGGTCGGCAAGGAAAACCGGCCCGATAACTCGGGCCGGCGTATTTTTTGAAAGTGTGA
+AGACGGTCAACCGTGGGAAGACTGTCACTCGCCTTCTTTTTTCTCTTTTTCGTCTTCTTT
+CTTGCTGCGCGAGGATGACGAACGCCGGGCGGGCTTGGCGGTCTCACCAGACTGGGCCTT
+GAGTGCCTCACTCAACTCTTCCATGCGCTTCTCCAATGCAATGATTTCGTATTGCACTGC
+CGTCTGCTTGTCCAGGGCATCCGCCGTGTTGCGGGAAATCGTCCACAGCAGCCACAGGGC
+GACCAGCAGAGCCACAAAGATCAGGAAACTCATCAAACTCTCTCCTCCAAGCCTGTTGGT
+TGAAAAGGTAGCGCAAAAAACGACGGAGCGCTCCCCAAAACGGCGCAAAAATCACCATGC
+CCCATCGTCGCCGCCGCGGCAAGCTTCAGTTGCTCCGACTAAAGACCGAATTCCGTCTGT
+GGATCGGCATAAGCCACCTTTCCACGGCTCAAAGTGAGCATGACACGGCCAGGTAGCGGT
+TGATCCAGCACCGGTGCATGCTTGCCAGCTGAAAGCAGCGTTTCGGGTGCCGGTATCCAC
+TGCCCGTTGGGATTGAAGAGCGTGAGATCCGCACGGCTCCCCGCTTCCAGGCGCGGCTCG
+GGCAAATTCAGCACCTGCGCCGGGCCCAGCGTCAAAGCCTGCAGGAAACGCGGGAGTTCC
+AGCTCTCCGGCATTGACCAGCTTCAGCCCCAACCCCAACAGGCTCTCGACCGTTGAAAGG
+CCCGGCTCGGTTTCCCCAAAGGGAGCCTGCTTGGCAGCCGGATCATGGGGCTGGTGCTGG
+CTCACGATAGCGTCGATCCAACCTTCGTTGACCGCCGCCAGCAAACCCTGCCGGTCTGCT
+TCGGTCCGTAAGGGTGGACGGCAATGAAAGCGGCTGTCGAAGTCAGCCAACCAGCCTTCA
+TTAAACGCGAGCTGCTGAATGGCCACATCGGCCGTAACGGGCACACCGCGCTCGCGCGCG
+GAACGCAGCAGCGCGACGGATCGGGCAGCGGAAAGCTGGCTCAGGTGGAGCCGGACACCG
+GTATCCTCTGCCAGCTGGATCAATTCGCCCACTGCGATGGTTTCAGCGATTTCCGGGATT
+CCGGGCAAACCCAGCCGCGTTGCCACCACACCTTCATGGGCATAACCATCGGCCGCGAGA
+TCAGGATTTTCCGGACGCATAAACAGCGTCAGTCCGAAGGTTTTGGCGTAAGCCATGCAA
+CGGCGCAGCACCCGGGCGTTGCCACGGGACAGCGAGCCATTACTCAAGGCGACACAGCCG
+GCGCGCGCCAGGGAGGCCATATCGCTTAACAGTTCCCCCTGCAATCCGCGGGTCAGAGCG
+CCCACAGGCAGCACCCGCACGCAGCCCTGCTTGCGTGCCCGCTCCAGTATCAGCGTGGTG
+ACGGCACCGGAATCATTGACCGGCGAGGATTCCGGCGAGGCGCAAACCGTCGTGAACCCG
+CCATGAGCGGCAGCGCGGGTTTCACTGGCGAGCGTCCCTTTCTGGTCATCACCGGGCTCA
+CGCACGAAGCAGCACAGGTCGATGAAACCGGGACTGATCCAGGCCCCGTCCGCATCGAAG
+ACCCGATCTGCGGCCTGATCCAATACCTGCTCACCCACAGCGACGATCTTCTGGTCTTCG
+ATCAGGACGGCACCGGACCGGACCTGCCCCGTACGGGAATCCAACAGCTGACCGTTTTGA
+ATCAGTAGTTTCATAGTGTCCTGCTTTGCTCCTGGGCGGCATCACCTTGATTCAGCTGGG
+CCAGTTGACCACTCATGACCATCGACATCACTGCCATGCGCACCGCAATGCCGTTGGTCA
+CCTGGTTCAGAATCACTGACCGGGGACTGTCCGCCACGGCGGACTCAATTTCCACCCCGC
+GGTTGATCGGCCCCGGATGCATGACAATCGCGTCGGGTTTGGCGTAGCGCAGCTTTTCCG
+TGGTCAGGCCGTAGAGACGGTAGAATTCCCGCTCTCCGGGCAATAGCGCGCCCTCCATCC
+GCTCATTCTGCAGCCGCAACATGATCACTACATCCACGTCCTTCAGCCCGCGCTGCATAT
+CGTTGAAGACTTTGACGCCCAGGGACTCCACATCTCTTGGTAGCAGGGTATTGGGGCCGA
+TCACCCGGATTTCGTCAGCCCCCAGGATTTCCAGGGCCCGAATCTGGGAACGGGCCACAC
+GGGAATGCAGAATATCACCGACAATCGCTACCACCCGGCCCTCGAAACCGCCTTTGTGCT
+GCCGGATCGTCAGCATGTCCAGCATGGCCTGGGTGGGATGGGCATGACGGCCGTCACCGG
+CATTGACGATGCCCACACCGGGCGTAACGTGGCGCGCGATAAAATGCGGCGCGCCGCTCT
+GGGCATGACGCACGACAAACATATCGCTGGCCATGGCTTCCAGATTCAACAGGGTGTCCG
+AGAGCGACTCGCCCTTGGAGGCGGCGGAGGTACTGATATTGAGGTTGAGTACGTCAGCGG
+ACAGTCGTTTGGCCGCCAGCTCGAAGGTACTGCGGGTGCGGGTACTGGCCTCGAAAAACA
+GATTGACCACCGTACGCCCACGCAACAGGGGAACTTTCTTGATGCGACGCTCGCCCACTT
+CGATAAAGGAGTCGGCGGTATCGAGAATTTCAGTCAGTAGCGGACGGTCCAGGCCATCCA
+GGGTAAGAAAGTGCCGCAGGCTTCCAGCGGCATTCAACTGCAGCTGCCGGGCAGCTTCGC
+AGGTATCAATCATTCCAGGCAACCTCTCTGGGGAGCCCCCTGATCAGTGACTTTTGGTTG
+AAGCATCCTTGGCTGGGTTTTCCCGCACATTTTCCCGCAACTCTACACGCAACGGATCCG
+GGCCCATCAGCTTGACCCGCTGGTCACGCTGAAGCTGCATTTGCTGACCCACGATATCCG
+GCTGGATCGGCAGTTCCCGCGCGCCCAGATCAAGCAGAGTCACCAGAATGATGCTGGCGG
+GGCGGCCATAGTCGAACAGCTCGTTCATGGCTGCACGGATGGTGCGCCCGCTCATAATCA
+CATCGTCCACCAGAATGATGTGGCGGTCTTCGGTGGCAAACGGCAGGTTCGAGGGTTTGA
+CCCGGGGGTTCAGGCCGATGCGGCTGAAATCGTCGCGATAGAAGGAGATATCCAGTTCGC
+CGAGGGGTTCTTCCAGGCGCAGACGCTTGTGCAGATAATCCGCCAGCCAGACACCACCGG
+TCCGGATACCTGTCAACACCGGATTAACGGCGCCGCGCGCTTCCAGGGTTTGCTCGAGCT
+GCGAACACATGGTTTCCAGCAGGCGCTCGACATTGATCTGGGCAGTCATGGATACACCTC
+GGTTCAGGGCGTGGGTATCTTAGGCTGCTGGTCCCGTTGCTGCAAGAACCAGCCCTCCAG
+GATCAGCACCGCCGCCAGGTCATCGACCCCCTTCACACCGAAATCCCGTCCACCTTCGCG
+TTCCACGATGGCCGATTTGGCGGCGAAACTGGTCAGTCGTTCGTCCATCATGGCGTAATC
+GCGGTGATACATGCCATGCAGGCGGCGGGCAAACTTGCGCGCCCGGCGACACATTTCGCT
+TTCCGAGCCATCCATGTTGAGCGGCAGGCCCACCACGAAGAAATCCGGCTTCCAGTCCGC
+GATCAACGCTTCCACTTCATCCCAGCGCGGGATCCCGTCACGAGCGCCGATCATGGTGAC
+GGGACTGGCGGTGCCCAGCATTTCCTGACCAACGGCGACACCAATCCGGCGCAAGCCGAA
+ATCGAATGCCATGACCTGGCGCTGACCTTCGGGTTTCAAATCAGGCATGGCCCACGCTAT
+CGGACAGCTGGCTCCAGTCAATACCCAACCGTGCCAGGGCCGCGGGCAGCCGCTGCTGCC
+ATGGAACGTTGAACAGGATGTCCGGGTCGGCGGGACAGGTCAGCCAGAAATTGCCGGCCA
+GCTCCTGCTCCAGCTGACCCGCGCCCCAGCCGGCATAGCCCAGGGCAACCAGATAGTCTT
+CAGGCCCGGTTTCCTCGGCAATGGCCTCCAGCACATCCCTGGAGGTGGTGACGGAAAGAT
+CGCCACTGATCTCAAGCGTACTCTGCCACTCGCCCCGGGACCGATGTAAGACGAACCCCC
+GCTCTACCTTGACCGGCCCGCCGGAATACACCGGCACATCGAGGTGGCCGCATTCGATAT
+CGAGCTGTTCCAGGATCTCACCCAGGGAGAAATCCAGGGGTCGGTTCACCACCAGCCCAA
+GGGCCCCCTGATCGTTGTGATCACAGATATAGGTCAGGGTCCCATTGAAATTGGGATCCT
+GCATGTAAGGCATGGCAATCAGGAACTGATTGCGGATGTAGGGATTCGCTTCGCTCATGC
+GGGTAGTATTCGCTGAGCAAACGGCTTTGGCAAGGCTATAAAGCCGGATCAGCCGTTGGT
+GGACAATCCCCGCGGCTCAAACGACCAGTCACGTATGATTTCCAGTACATCCTTGCGCTT
+CCGCAGCTCCGGCGGGAAGGGCGCAAACGGCGCGGCCAGCCGGACGATGCGCATCGCGGC
+CTGATCCAGCACTTTATAACCGGATGACTGCAGGACCTGAATATCCTTGACGTGACCATT
+GGGCAGGATATCCACCAGCAGCCGCAAGGTTCCATGGATACCACGCCTCCGGGCCGCTTC
+AGGGTAGTTGAGGTTGCCGATTCGGGTCACCTTGTTGACCCAGGCCTGAACGTACCAGGC
+ATCGGTGGATTTGAGTGTGGAAGCGGCGGTCACGCGCAATACCCTTGGCCGCTTGGCATA
+ACGCTGGGTTTCCTGATCCAGCTTGGCCTCAAGGCTGGCGATCTCCAGCGCCCGGGACAT
+CAGACTTTTATGATTGTGTTTCTGATGCGCCTTCTGTTCCTTGTCGTCGGAATCCACCTG
+CTGCGTCGCCTGTTGGGAGACGGTCGTCACCACATGGCGCTTTTCCGGCTTGGCCTGGCT
+GTGCTGGGGCTGGGAACGGGGAATCGGCTTCACCTTGTGCACCTGCGAAGCGTTGATCGG
+CGCCCGGTGCCGTGTGGTGATCTGGGCTTTCTTGCTCAGAGTGCCACTGCCCTTCTGATT
+GGTCTGGGCCAGGTAATCGGCATGTTTCGGCGCTTTCTGGTCATCCCGCTGGGCCAGGGT
+GATATCCAGGGTACGGGCACTGGGTTGGGGCTTGTGCGCGGTGAACGTCACACCCAACAC
+CACGATGGCGTGCAAAACCAGGGCCAGGAAGAGAGTAAAAGTCAGCCGATCGGTATCACT
+GACCCGAACTGCGGATGCCGCCATAAACGCTTTTCGTAACAGGGCTTAATCTTAAATGGA
+CAGGCCGGAACCCGGTCCTCGTCGATCCTTTAGCGCCGTTGGCGCCCCATGAAGTTTGAC
+TGTAAATGGCCAACCTGTCCATGTCAGCACATTACAGTTGCGTTCACATTTTGTTCAGCG
+CCGGGCCAAACGGTCAGCAATCACCTGCATCAGCTGGTCGGAGATATCCAGATCGTACTC
+CCGATCCAGTTCCCTTACGCAGGTGGGGCTGGTGACGTTGATTTCCGTCAAATAATCACC
+GATCACATCCAGTCCCACGAAAAGCAGGCCCTTTTCGCGAACCATCGGCTGCACCTGCTC
+CACGATCCAGCGGTCCCGGTCAGTCAGTAATCGCCCCTCGCCACGACCACCTGCGGCGAG
+GTTTCCGCGGTGTTCACCCTGGGAGGGAATACGAGCCAGTGCATAGGGCACCGGTTCGCC
+GTCAACCAGCAGGATACGTTTGTCACCCTGGGTGATTTCAGGCAGGTATTTCTGGGCCAT
+GATCTGGTGGCTGCCGTCTTTGGTCAGGGTTTCGATGATCACACCCAGGTTGTCGCCGTC
+CTCGCGCACCCGGAAAATCGAACGACCACCCATTTCATCGAGCGGCTTCAACACCACATC
+ACCGTGTTCGGCATGAAAGGCCCGCAACCGGGCTGCATCGCGGCTGACCACCAGCGGCGG
+CGTGCATTGAGGGAACCAGGTGGCAAACAGCTTTTCGTTGCAGTCTCGCAGGGCCTGGGG
+TGGATTCACCACCAGTGTGCCCAGCCGCTCGGCGGCCTCCAGCATCCAGGTGGTTACCAG
+GAACTCCTTGTCCACGGGTGGGTCCTTGCGCATCAGGATGACATCCAGCGAGGCCAGCGC
+GCGGTCTGACGGTTCACCCAGCGAGTACCAGTCGTCCGGGTTGGCCGCCACGGTGAGTGC
+CTGGGTCCGCGCGCGGGGCTCACCGTCGCGCAGGTAAAGATCCTGCATCTCCATATAATG
+CAGTTCCCAGCCGCGGCGCTGGGCCGCCAGCAACATAGCCAGGGACGTGTCCTTTTTGTA
+ATGGATCGCCCCGATGGGGTCCATGACAATACCGAGTTTCACACTCATGAGCTGAAGTTT
+CCTCTACCAGGCGGGGTACGACGCAATCGCCGCTGCATTATCGGGCGGTCGCAGCCTTTC
+AAATAGCTGCTATGCTGTGAGAATGAGCGGTTTTGTGCAAGCGGTGTTTTGTCCCGCTAT
+ACGCTGCCGCCATGAGGATGGATTCGGTGGGCTTGGACGCCTGACTGCAGGCAGGACGAG
+CGCGGCGCGGTCCGCCAGGCGGTCAGGTGACGGGACGCGGTGTCGATCACATTTAGACAC
+AAACAAAATCTTTTGCGGTCCAAATCCATACACTATAACTAGTAAAGGCTTATAGAACAG
+CTTCCGAATCTGTGTTAAAAAGGCGCGTCAACGTGCCAGCCGCGATAGGAAAAGGCCTCA
+AGGAACAGACGGCATCAGTCGTTTTACGCGCATAGCGGAGCGCGTCAGATCCCTGCGATA
+GCGTCGATCCGGTGCCCGACAAGGTGCCATCGCGAGCGACCCGCGGCAGGCGGCGAACGA
+CTGCTGAGGCGGGCTGTCCCAGGGGCCCATTAACAACGAATCCCCGTTATGCGCAAGGCT
+GTTGGACAATGGAAGACAACTTCGAAAATCTCAAAATCATGGTGATCGACGATAGTAAAA
+CCATTCGTCGCACCGCGGAAACACTCCTGAAAAAAGTGGGGTGTGAAGTGATTACGGCAA
+CGGACGGATTCGATGCCCTTGCCAAGATTGCAGACTCCCATCCAGACATCATTTTCGTCG
+ACATCATGATGCCGCGGCTGGATGGCTACCAAACCTGCGCCCTGATCAAGAACAATTCAG
+CGTTCAAGAGCACGCCAGTGATCATGCTGTCCAGTAAGGATGGTCTTTTTGACAAGGCCA
+AGGGGCGTATCGTCGGGTCGGATCAGTATCTGACCAAACCCTTTAGCAAGGACGAATTGC
+TCAACACGATTCGTCAGCACATACCCAGTCGGGAAAGCACTTGATTGCAATACGCTCAAG
+ACGCCTGAAACGTACCGAGGATCCCATGGCTCGCATTCTTATCGTTGATGACTCACCTAC
+GGAAGTGAAAAAGATTTCTTCGCTGCTGGAGAAGCACAATCACGAGGTGCTGACCGCAGA
+CAACGGCGCAGACGGTGTCGCCAAGGCCCGTGCCGAAAGTCCGGACCTGGTGTTGATGGA
+CGTGGTCATGCCCGGATTGAACGGCTTCCAGGCAACTCGCCAACTGACCCGCTCTCCGGA
+TACCGCGGATATTCCCGTGGTCATCGTCACCACCAAGGATCAGGAAACCGACCGCGTCTG
+GGGAACCCGCCAGGGCGCCAAGGGCTATCTGGTGAAGCCGGTCAAGGAAGATGAACTGAT
+CAAGACGATTGACGACCTGCTTGCATAACGGGTCGCCCCTGTAACCGACGGAGTACCGCA
+TGTCCGCCCAGGCAGCTCCTTTCGCCGTTCTTTCGGATATCGCCACGCGCAGCCGGTCGC
+AATCCCGGGGGCTGCCCGCCCAGGAAGAAGCCGTCGAGCTGTGGAACGGGATCGGGTTCA
+GCCTTGCCGGGCAACTCTACGTGGCACCCATGGGCGAGGTGGTGGAAATCCTGCACCTGC
+CACGCTATACCCAGGTTCCCGGTGTCCGCGCGTTCATGGTCGGAGTTTCCAACGTTCGCG
+GCCGTCTCCTGCCGCTGGTGGACCTGGGGCTTTTCCTGGATTTTCCCCGTTCCGTGGTCT
+AGGTGTCGTTGTACGTGGGATCCCCGGGTACCGAGCTCGAATTCGCCCTATAGTGAGTCG
+TATTACAATTCACTGGCCGTCGTTTTACAACGTCGTGACTGGGAAAACCCTGGCGTTACC
+CAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCCAGCTGGCGTAATAGCGAAGAGGCC
+CGCACCGATCGCCCTTCCCAACAGTTGCGCAGCTGAATGGCGAATGGCGCCTGATGCGGT
+ATTTTCTCCTTACGCATCTGTGCGGTATTTCACACCGCATATGGTGCACTCTCAGTACAA
+TCTGCTCTGATGCCGCATAGTTAAGCCAGCCCCGACACCCGCCAACACCCGCTGACGCGA
+ACCCCTTGCGGCCGCATCGAATATAACTTCGTATAATGTATGCTATACGAAGTTATTAGC
+GATGAGCTCGGACTTCCATTGTTCATTCCACGGACAAAAACAGAGAAAGGAAACGACAGA
+GGCCAAAAAGCTCGCTTTCAGCACCTGTCGTTTCCTTTCTTTTCAGAGGGTATTTTAAAT
+AAAAACATTAAGTTATGACGAAGAAGAACGGAAACGCCTTAAACCGGAAAATTTTCATAA
+ATAGCGAAAACCCGCGAGGTCGCCGCCCCGTAACCTGTCGGATCACCGGAAAGGACCCGT
+AAAGTGATAATGATTATCATCTACATATCACAACGTGCGTGGAGGCCATCAAACCACGTC
+AAATAATCAATTATGACGCAGGTATCGTATTAATTGATCTGCATCAACTTAACGTAAAAG
+CAACTTCAGACAATACAAATCAGCGACACTGAATACGGGGCAACCTCATGTCCGAGCTCG
+CGAGCTCGTCGACAGCGACACACTTGCATCGGATGCAGCCCGGTTAACGTGCCGGCACGG
+CCTGGGTAACCAGGTATTTTGTCCACATAACCGTGCGCAAAATGTTGTGGATAAGCAGGA
+CNCAGCAGCAATCCACAGCAGGCATACAACCGCACACCGAGGTTACTCCGTTCTACAGGT
+TACGACGACATGTCAATACTTGCCCTTGACAGGCATTGATGGAATCGTAGTCTCACGCTG
+ATAGTCTGATCGACAATACAAGTGGGACCGTGGTCCCAGACCGATAATCAGACCGACAAC
+ACGAGTGGGATCGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGGACCGTGGT
+CCCAGACTAATAATCAGACCGACGATACGAGTGGG
+>NODE_42_length_1523_cov_23.4108_ID_83
+AAATCTCTTTGGAGAACATTAGGGGCGGTTTGCCCTACCTCTCCTCTGTAAGAGCGGTAT
+CGCTTGACCTTAATCGCTGCTTTAAGTGAGAGGGTTCCCATCAGGCGCTGAACAGCTTTA
+TGGTTAATCTGTTTCCCTTCTCGATGAAGAGACAGCGTTACCCTACGGTATCCGTATCGG
+CCTCTATTCTCGTGATAAATCTCACTAATACGCTTTTTAACGTCCGCATACTTGTCAGGC
+TTGCTGAGAGCCTTTAGATGATAATAAAACGTACTGCGCGGTATCTCCGCAGCCCTGAGA
+AGCTCATCAAGAGGATAAAACTGCCTTAGCTCGTTGAGTACTTTCACTTTTTCGTGGGAT
+GAGCTAAGGCTTTCAGCTTTTTTAGATACATAAGCCGCGTTTCAAGAAATCGAACTTGCC
+TTTCAAGATCCTCAATGCGTCGGTCTTTTGACAGCTCCAATGCTGATGCCGCTTTTTCTG
+GATCAACTGATATTGCAATGTTTCTTTTGGTGCCAATCTTGAGCGCGCGTAAACCAGCTT
+CTCCGCGCTCTTCATAGACCTTCAGCCACCTGGCTACAGAACCACTACCAGCAAGCATAA
+AGTGAGCAGCAGCCTGATTAAGGGACATGTGCTGCTCGATCACAGCTTTCACGACCTTAA
+TACGCAACTCTGGATCAGCACTAACGCCTTTAGGTTTGGGAATTAAACCTTTTTCTCCAT
+GTTTTTCATAGAGGGCAACCCATGTCCTGACCTGGGTTCGGGGGACACCAAAACGTGCCG
+AGATGATCCTGTAACCATCATCAGTTGTGAAGTAGTGATTCACGACTTCAAGGCGCTTTT
+CAAAAGGGTATTTTGGCTTTGACATATTAGGGGCTATTCCATTTCATCGTCCAACAAAAT
+GGGTGCAGTACACCTTGTACTGACCCCAAAAAGTTGGACAGTTAAACACGAGGCATATAG
+GTCTGATTCCGATATTCAATTGGAGTCAGACCTTTTAATTTCAGGCTAATTCTTCTGCTG
+TTGTAGTATTCAATATATTCCGTAACAGCATCCTTCAGTTCGCTTATATTACTGAACTCA
+TCAAGATAAAAACACTCCGACTTTAAGGTTCCAAAGAAACACTCCACCACAGCATTATCC
+AGACAATTGCCTTTTCTGGACATGCTTTGTTTAATACCATGTTCTTTAAGGATATTTTGA
+TATCTTCTCATACGATACTGCCATCCCTGGTCAGAGTGCAGAACAGGATGCTCGTGAGGA
+TTAAGCTTTTTGAATGCCTGATCGAGCATATTCTCAACCATGTTCATCACTGGTCTTTCC
+GAAAGGCTGTAAGAAATAACTTCGTTGTTGAAGAGATCTATTACTGGAGACAAATACAGC
+TTGCGCCCATTGACTGCAAATTCAGTAACATCGGTAACCCACTTCTCGTTTGGCCGCGTA
+GCCTTGAAATCTCTTTGGAGAACATTAGGGGCGGTTTGCCCTACCTCTCCTCTGTAAGAG
+CGGTATCGCTTGACCTTAATCGC
+>NODE_4_length_32829_cov_185.347_ID_7
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+CACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGTTGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCACCTATGTCTTCGGCTCCAG
+CCCTATCACCACACCCTCGCTGCTGGACGGTGTCTGGCGGCTGGATGGCGTAGCCATTCC
+CTACAGCCAGATCCTGATTGGCGTGATCGCCTGGGTCGTATTGCTGGCACTGTGGCTATT
+CGTCACCCGTTCGCGCCCCGGTAAGGCCATGCTGGCCGCCTCCATGAGCCGGACCGGTCT
+GGCTCTGGTGGGTTACGACATCGGCAAGGTCTATCTGCAGGTATGGGGACTTTACGGCTT
+ACTGGCCGGTATCGCGGGTGTACTACTGGCGTCGTTTACCGGCGCCAGTGCGTCGATTGC
+CATCTCGCTCACGGTCAACGCTTTCATCATCGTCGTGCTGGGGGGCCTGGGTAATGTCGC
+GGGCTCACTGGGTGCCGCCTACATCATCGGCCTGCTGGGCACGCTGACGGCTTATCTGAT
+TTCGCCGTCCGTGCGCGAAATCCCCGGGCTGCTGGTGTTGATACTGATTCTTTACGTACG
+GCCCCAGGGCCTGTTCGGCCGGCATTGAGGAGGCATCATGGCATCGCGGATTCATTGGGA
+TTGGCGCGCCGGTCTGGTTTTGCTGGCGCTGATCGTGCTGGCCTTTCTGCCTTTCGGGGT
+ATCCGGCTATATTCTGGGCGTCATGACCGTGGCGTTTTACCTGGCGGTCTATGCCATGTC
+CTGGGACCTGCTGTTCGGCTATGCCGGCGAGGTCAACTTCGGTCCCACCTTTCTGGTGGG
+TCTGGGCGCCTATGGCGCCGGGCTCAGTAACAGCGTATTCAACATCAGCGTCTGGCCCAG
+CGTGGCCATCGGCACCCTGGCAGCCGTAATCGGCGGGCTGGTGCTCGCCGGTCCCGCATT
+GCGACTGCGCGGACCGTACTTCGGCCTGGTGACGCTGGTCGCTGTCATACTTCTGGAAAA
+GGTCATTGGCCTGCTCTCCAGCTATACCGGTGGTGAAATCGGGCTGACGGTCATGGATGT
+GCTCACCATCAGCCAGAGTGGCAACTACTACTATGCCTTTGGTTTCATGGTAATTTCCGC
+CGTCATCCTGCGCATTATCGCCCGCTCTTCCATTGGCCTGATTCTGGAAGCCAGCGGCCA
+GGACCCGGTCGCTACCGAAGCGCTGGGCTTTAACGTCACCAAGTTCAAGTTCATGGCATT
+CACCCTGTCCGCGTTCTTTTCCGGACTGGCCGGCGCGCTGACGGTGTTCTACCTGGGTTC
+GGCCTCACCGGGCACGGTCGTCTCCGTGTTTGTCACCATCCAGATCATTATCGCCACCCT
+GGTGGGGGGCCGGCGCTCGATCATCGGGCCGATTCTGGGGGCGGTGTTCCTGATCGCCGC
+CGGCGAGATACTCCGCCCGCTCGGACAACTGAGTAATGCCGTGGTGGCGTTGATTGCGCT
+GCTCGTGGTGCTGTTCGCACCCAACGGCTTTATTGGCCTGTTTTCCCGCACGGGAGGTGC
+CCGATGAGCGTATTAAAGGCACAAGGACTCTATAAGCGTTTTGGTGGGTTACAGGCGGTC
+AACAACGTGTCGTTTTCGGTGGACCGCGGGGAAGTGCTGGGGTTGATCGGCCCCAACGGC
+TCGGGTAAATCCACAACGCTTTCCCTGCTGATGGGCGTCACCCGGCCTGATCGTGGCTCC
+GTCCAGCTGGACGGGCAGGAAATGGCGGGCTGGCGCACGCACCGGATTGCCAAGCAGGGC
+CTGTCGATGGTGTTTCAGCACTCCCGGCCCCTGCACCGCCAGACCGTGCTGGAAAACATC
+AAGCTGGCGCTGCTGCCGGACACTCTCTGGCAACTGTTTCCGCCGCATACGCTGGACCGG
+CGGGCCCGGGAAATCGCCGAGCGGGTTGGTCTGCATAATGTCATCGACACCCTGCCAGGC
+AACCTGCCCTTCGCCGACCTGCGAAGACTGGAGATCGCCAAAGCCCTGGCCCAGGACCCG
+TCTGTACTGTTGCTGGACGAACCCTTCGCCGGCCTCTCCCCCAGGGAAACCCGGGAGTTC
+GCCGAGTTGGTGCACCTGTTCCGGGAAGAAGGCCGGGCTGTGATCCTGGTGGATCATAAC
+GTCAAGGAAGTGGCGGGACTGGTGGATCGTATTGTGGCCATGCACGCCGGGCAGGTGATT
+GCCGAAGGAACGCCGGATGAGGTCACCCGCGACCCGAAAGTCCGCGAAGTCTATTTCGGT
+CAGTCGCTGGAAAATGCCAGCGGTATTCACGCCGACGGCGATCGGCGCTCCGAAGGCAAT
+GGCAGTGAAGCCTTGCTGGAGATCGATCTGCGGTCGGTCCGTTACGGCCTGGCCGAGGCC
+CTGCGGGATATACAGATACAGATCAATCAGGGGGAGTGTGTTTCCGTGGTCGGCATCAAC
+GGGGCCGGCAAGACCACCCTGTTCAAATCCATACTCGATTTCCAGGGTTATGAGGGCGAT
+GTCCGCTGGCAGGGCACCTCACTGACCGGCCAGGGTCCGGGCCAGGTCGCCTCCCAGGGG
+ATTGCCCTGTGCCCGGAAAGCCGCGAGCTGTTTGGTTTTATGACTGTGCGCGAAAACCTG
+GAGCTGGGTGGCCACAAGCTGGACCGGCAAGCGCACGAAAGCCAGATGGATCGGGTTTTC
+GACCTGTTCCCGGTATTGCGCCAACGCCAGGCGCAGGCCGCCTACACGCTCAGCGGGGGC
+GAGCAACAGCAGCTCACCATTGGCCGGGCCCTGATGCAGCAACCCAAACTGCTGATTCTG
+GACGAACCCACACTGGGGCTGGCGCCGCTGGTGATCGAGAACATCTCCGAAGCCCTGCAC
+AAGTTACAGCAGGACAGTGGCATGACCCTGCTGCTGGGCGAACAGAACCTGACGTTCGCA
+TTACGCCATTCGCAGCGTATCTATCTGCTGGAAACCGGTAATCTGCGCTGGCATGGACCG
+GCGGAACGGTTTATCGAGGAGGTGGGCGAGGATGTTCTGTAACGGCAATCAGGGGTACGA
+TTTTTCCATCAATTCACATCCTGGCCATGCCCATCAGATGCAACGGAGGAGCCATGCAAC
+GAACAGCCAGAGCGGCCCTGTGCCGTGAATGGAACGGCCCGATCCAGGTGGAGACGATTC
+GTGTCGACCCACCCCGCCGTAACGAAATCACCATCAAGCTGCGGGCGTGCGGCGTCTGCC
+ACAGCGACCTGTCCGCCGCTACTGGAGTTATTCCCTTCCCACCGCCGTTGGTGCTGGGGC
+ATGAGGGGGCCGGCACCGTAATTGCGGTGGGCGAAGGCGTGACGGATTTCCAGGAAGGCG
+ACCATGTGGTCAGCTCGTTCATCTATATGTGCGGCAAATGCCGCCAGTGCAGCCGCGGCC
+GCCCAGTCCTCTGCGAGCAGGCCCACAAGGCACTGCACCATCTGCCCGATGGCACGGTGC
+GCACCCATGATGGCGACGGCAATCCGCTCAATGTCTTCGGCGCCTGTGGTGTGATGGCCG
+AATATGCCACGCTGCATGTGAACAATGCCGTGAAGATTGACCCCGACGTGCCCCTGGAAC
+GGGCCGCGCTGGTGGGGTGTGCGGTGATGACCGGCGCTGGCAGCGTTTTCAATACCGCGC
+AGCTGGAACCGGGGTCCACGGCGGCGGTATTTGGTGTCGGCGGCGTGGGCCTGAATGCCA
+TCCAGGGCTGCGCCATTGCCGGGGCCCGGGTGATCGTGGCGGTAGACACCAACGAGGAGA
+AACTGGCGATGGCCCGTCAGTTTGGCGCCACGCACACGGTCAACGCCCGTGAGCACGACG
+ATGCCGGCAAGGCGGTAAAGAAAATGACTGGCGGGGGGGATTATGCCTTCGAGTGTGTGG
+GATCCGGCGTCACCGTCGCACAGGCCTACGGCTCGCTGGGCCGGGGCGGAACCGCCGTGG
+TGGTCGGCGTTGCGGACGTTAAGGATAAGACCACGTTTCGCACCTTGTCATTGCCCGCGG
+ACGAGCGCACTCTCAAAGGCAGCTGGCTGGGCTCGGCCCGGCCCCAATTCGATTTTCCCC
+GTCTGCTGGGCCTGTATCAGGGCGGCCGGCTCAAGCTCGATGAGCTGGTCACCCATACCT
+ACACCATCGACGAGGCGCCGCAGGCCTTCGAGGACCTCAAGGCCGGTCGCAATGCGCGCG
+GCGTCATCCTGTTTGACTAGGGAGTTACCATGACGATCAAAAGCTACGACAGTGTCTATT
+TCGACGGCCGCTGGCAGCCGGTGGACGGCGAGCGGCTCTCGGTTTACGAATCCGGCACCG
+GCGAGGTGATGGCCAGCATTCCCGGCGCCGCACCGGCGGTGATGCAGCAGGCCATTGATG
+CCGCCCACAACGCCTTCGACAGTTGGTCGCGTCGACCACTGAAAGAGCGGCTCAAGTACA
+TTGAAGCCCTGCACGGCCAGCTGGTGGCCCGCGCCGAAGAAATCGCCACCACCATCAGCC
+GTGAAGTGGGCATGCCGCTCAAGCTCTCGCGCAACATCCAGGCCGGCCTGCCCATCGCCA
+TTACCGACAGCTACCTGAAACTGCTGCCGGACTTTCCCTTCGAGGAAAAAGTGGGCAGCT
+CGCTGGTGCAGTACACACCGGTCGGCGTGGTGGGCTGCATTACCCCCTGGAACTACCCGC
+TGCATCAGGTGATCCTGAAAGTGGTACCGGCGCTGGCCGCGGGTTGCACCGTGGTGCTTA
+AGCCCAGTGAAGTGTCGCCCCTGAGCGCGTTCATGCTGGCCGAAATGTTCGATGCCATCG
+ATCTGCCGCCCGGAGTTTTCAATCTGGTCTCGGGCCTGGGCCACGTGGTGGGCGACAGCC
+TGACCGGTAGTAATAAGGTGCGCATGCTGTCCTTCACTGGCTCGCCCGGCACCGGCCGGC
+GCATCTTCCATGCCGCCGCCGAGGACTTCAAACGACTGGCACTGGAAATGGGCGGCAAAT
+CAGCCTCGGTGATCCTGCCCGACGCCGATCTGGCGACAGCGGTCAAGGGATCGGTCAACA
+ACTGCTACCTCAATTCGGGCCAGACCTGCATCGCCTGGACCCGCATGCTGGTCCCCGCCG
+ACAAACACGACGAAGCCTGCGAACTGGCCGTTGCCGCCGCCAAAAAACTCACGCTGGGCG
+ATCCGCTGGACGAGAACACCCGACTGGGTCCGCTGGCATCCAAAGAACAGCTCGAGCGGG
+TGCGCAATTACATCCGGGTAGGTATCGAGGAGGGCGCCAAGCTGATGACCGGCGGCCCGG
+ATGCTCCGGCAGGGCTGGACAAGGGTTACTTCGTCGAGCCCACCATCTTCGCCAATGTCG
+ACCCCCAGTCGCGTATTGCCCAGGAGGAGATCTTCGGGCCGGTACTGTGCATCATTCCCT
+ACCGGGATGAAGAGGAAGCCATCGCCATTGCCAACGGCACGCCTTACGGTTTGTCGGGGG
+GAGTCTGGTCGGCGGATCAGGATCACGCAATCGCTGTGGCCAGCCGGCTGCGCACCGGTC
+AGGTAACCGTCAATGGTGGCGCTTTCAACCCCGAGGCACCGTTTGGCGGCTTTGGCGCCT
+CTGGCCTGGGTCGGGAGTTTGGCCGCTGGGGCCTGGAGGAGTTTCTGGAGGTGCGGTCGT
+TGCAGCTTTAAGCTGCAACGCCCTGTCTGAGGTCGCAGGCCTGACGTCGCTTGATCGTTG
+GCCTGCGAATATCAGACGTGCGATGCCAGACGTTCAAATCACTTACAGGGCCCTACCCAC
+TTACCATCACTGTCCACAACGGTCTTATAGGGGCCATTGGGCGTCTGCATGAGGGCATTC
+ATGTGAATGTGATAGGACGTCTTGCTTTGAAGGGTAAACACGCCTTCGGTGCTTGCCTGT
+GATTTGCCGGTACAGGTCATTTTCCAGTGGACCTTGTTACCGCTCCGGGAGTATTCGTTC
+AGCTTACAGCCGGGTTGCTGGGCCTCTTCAATGATCGATTTGATCGAGCCAGCCTGCTCA
+GGCTTTACACAATTGGTGGAAGAGTGAGGCGGAATCTTGACTGACGAGCCGGGAATGGTG
+ACATGAATCGTCTGTTTCCACTGACCGGGCTTGATTGCGTCTTCGGCCTGGGCCACCAAC
+GGGAAAAGCAACATCAGGGCGACAATGAAACGAAGCATGAGCTCTCCTTACTCTTGTGTC
+GACAAATAGGACGGAACCGCAATTATAACGCGGATCGGCCACGAAAGTCCCTTATGACAC
+CCCCGGCTCTGCGGGATTTTTCCCAGCCTGCGATCTCAGACTTTCGACCTCAGACGTTAC
+CGGTCAGGCGTCTGGTTGGCCAATGCCCGCAAACGCGCTTTCAGAATCTTGCCTGCCGGC
+GTCACAGGCAGCTGATCCAGAATATGGATTTCGCTCGGCCGCTTGTAGGCTGAAAGCCGC
+GCGGCGGCGAATTCGGACAGCGCCGATTCAGTCATGTCATGGCCCGGCGCAAGCTGCACG
+TAAGCGACGACCTCTTCATTGCCCGTAATCTGCCGGCCCACCACGGCAGAGAGCGTCACG
+GCCGGATGCTCATTCAAAACGGCCTCCACGTCCGGTGGATAGACGTTGAAACCGGAACGG
+ATAATCAATTCCTTGGCCCGCCCGACAATATGCAGCTGACCGTCCGGATCGATACGGGCC
+AGATCGCCGGTATCCAGCCAGCCCGCGTCGTCCAGCACCGCCCGGGTCGCTTCCGGTTTG
+CGGAAATAACCACGCATGATGGAGGGCCCCCTCACCCGCAGTTCTCCCACCTCGCCCTGC
+AGCACCGGCTGACGGCTTTTCAGGTGCACCACCTCGTAGTCCAGTCCCGGCAGGATACGG
+CCGACGCTGCTGGCTTCACTGTCTTCGCCGATCCGGGTCTGGCTGATGGTGGGGCTGGCT
+TCAGTGAGGCCATAACCGTTATGCAGCGTGGTACCGAAGGTCGCTTCGACGCGGGTCTTG
+AGGTCGGTATCCAGGGGCGCGCCACCAGCAGACAGATAGTCCAGCGCCGGTGCGACCAGC
+TTCCGGTTGTGCTGATGGAGATACTCCAACGTACGCGCATACATGGCCGGCACCCCCTGC
+AGCACCGAAATCCGCTCCCCGGCCAGGGCGTCCAGCAGCGCACCCGCTTCAAACCGGGGC
+ACGGTATGCAGGCAGGCGCCGTTGGCCAGTGAGCCCAGCATCACCGAAGACAGGCCAAAT
+ACATGGGAACTGGGCAGCACCCCGTAAACATGACGGCCCGGACGCAGATTGCGCAAGCCG
+CCGGAGACGCGGGCAATGAACAGAATAGCCCGATGGGTCAGCATCACGCCCTTGGGTTGG
+CCGGTGGTGCCGGAGGTGTAGATCATCGCCGCCACCTGGGTGCCATCCTTCACCACCGGT
+TGCGGCAGGCTTTGCGCGGCGGCAGGACCTACCGCAAATTCGCCCAGGGGATCCAGGTGG
+ACGATATCGGCATCGTGACGTTGCGCATGATTACGGGCATCCGGGGAGACTTCGGTGGTG
+TAGATCAACAGGCGCGGGTCGCAGTTGTCCCGGATGGCATCAATCTCGTTATCCGCCAGG
+CGGGCATTGATGATGGCGGCCCAGGCGTCCAGCCCGCTGGCCGCCAGTAACAGCGCCACC
+AGGGCACGGCCATTCTCACTCACCAGCATGAGGCGGTCACCCGGGCGCACTCCCTGCCCA
+ACCAGCCATTGCCGGGCCGCCGCGACCGCCGCAGACAGTTCCCGGTAGGACCAGCGGACC
+TGGTGATCTACCAGCGCTTCAGCCTCCGGATCAGCCTCCCAGTGCTGGGCGACGCCCTGA
+TGAATGCGGGCAGGCAGCGCGGCGGTGATCTCGCTGGCCCACCGACCATTGATCAGTTCA
+TCCGGGGCCCGCATTAATCGGCCTCCCGCACCATATTGCGGGCGATCACCAGCTGCTGAA
+TCTGGCTGGTGCCTTCATAGATCCGGAACAGCCGTACATCGCGGTAGAAACGTTCCACCG
+CGTACTCGGCCATATAGCCGGCGCCACCGTGAACCTGCACGGCCCGGTCCGCCACGCGGC
+CCACCATTTCTGAACAGAACAGCTTGGCGCAGGAAGCCAACGTGCTGACGTTCTCACCGG
+CGTCCTTGCGTCGCGCCGCATCCAGTACCATGCAGCGGCCGGCATAGGCTTCGGATTTGC
+TGTCCGCCAGCAGGGCCTGGATCAACTGGTGCTCTGCAATAGGTTTGCCGAACTGGGTCC
+GCTCCATGGCGAAGTGCAGCGCGTCGTCGAGGACACGCTCAGCGACGCCGACGCAGACAC
+CGGAGATATGCAGCCGCCCCCGATCCAGCACCTTCATCGCGGTCTTGAAGCCGACGCCCT
+CCCGGCCGCCGATAATGTTTTCCGCCGGCACCCGGCAGTTATCGAAGATGATGTCGCAGG
+TATGGGCACCTTTCTGGCCCATCTTGCGGTCGGGTCTGCCCCGATGCAGCCCTGGCGTAT
+CGCCTTCCACGATAAAGGCCGTGATGCCACCGGCACCTTTATTATCGGGGTCGGTCCGTG
+CCATTACCGTAAACAGGCCGGCTTCAGGGCCGTTGGTGATATAGCGTTTGGTGCCGTTCA
+GCACATAATGATCGCCATCCCGGGTAGCGGTGGTGCGCAGGGATCCGGCGTCCGAGCCCA
+CATCCGGCTCGGTCAGGCAGAAAGAGCTGATCAGCTCGCCGGTGGCCAAACGGGGAATGT
+ACCTGCGCTTCTGCTCGTCCGTACCATCGATCAGAATGCCCTGGGAACCAATCCCGTTAT
+TGGTGCCGAAAATGGAACGAAAGGCCGGGGACGTCCTGCCGATCTCCATGGCGACCAGCG
+CCTCTTCTTCCATAGTCAGACCCAGGCCACCGTATTCCTCGGGGATCGACAGGCCGAACA
+GGCCCATGTCCTTCATCTCCTGCAGAATGTCCTCGGGAATGGCATCATCCTGCGCTACCT
+GCTCCTCGCTGGGAACCAGCCGTTCACGCACAAATCGGCTGATGGTATCGATAAGCTGGT
+TGAGGGTCTCTTTATCACGAATCACGGTTGATCACCTGCTGCAATGAATTCTAAAGACGC
+CGCAGCGCGGCTTCGACGTTCTGTACCAGTTGCTTGAGTTTCGGGCCCAATTCCGCATCC
+AGCCGCTCTTCAGGCAACACGAAGGACGGGCCGCCACAATTGAAGGCGTAGATATTGCCG
+TTATCCGACTGCACCAGTGGCACGCCCACGGCGTTGACATCCCGTTCCCAGGTGCCGACG
+GTCTTGACGAACCCCGTCTCCTGGTACTGGCGTATGGCCCGTTCGATTCCTCGCCGGACC
+GGTGGCCAGCGATTACCCGCGTGGCGCTTGATATGATCCATCAGATAGTTGCGCTCACCT
+TCCGGCAGGGCTGCCAGAAACGCCCGGCCGACGGCGGTCGTCGCTATGGGAATGCGCGAG
+CCCACGTCCAGCCGCAACGTCACCGCCCCGCTGCCGCGGCAATTCTCCAGATAGATCATG
+CTGAGCCTTTCCCGGGCCCCCAGGGACACGGAGGCATCGACGTCGTCCGCCAACTCCTGC
+ATCAGAGGCCGGGCGATCTGGCGGATGCCAAACGTCGACAGCGTCGCATAACCCAGGGCC
+AGTGCGCCGGTGCCCAGGGAATAGCGTTCCAGGCGCTGGGAATAGGACAGGTAACCCAGC
+TTGGTCAGGGTGTAGGTCAGCCGGGTAACGGTCGGCTTGGGCAAGCCTGTACGCCGGGCG
+ATCTCCTGATTACCGAGAAAACCGTCGCCGGGGCGAAACGCCCTTAACACCTCCAGGCCC
+CGAGCCAGCGCGGTTACGAACTTGCGGTCCTTGGCGCCATTCTGCGGGTCCAGCGCCGCG
+TCCAGGCCCAGGTCACTGTTGTCATCCACCACGATTTGCCCCCACACCCCGCGTGCTTGC
+CAATACCAACCCAAGCGGCGCCCATGGCGCCTTTCAGTTGCATTGGACTCTGTCACGCCC
+TATGCTATCTGTCAAGTTTGCGAAACGTTGTTTCGCTTTGCGGAATACACGTGAGTCCAT
+GGCCTGAGCCGCACCGTTCACGAGGACCCCACCATGCTCGACGCCTATCTTTACGACGGT
+TTACGCTCCCCCTTCGGCCGACACGCCGGCGCACTGTCGCCCCTGCGTCCTGACGACCTG
+CTGGCTACCGTCATTCAGGCTCTGATCGCACGCAGCGGCTTTGCGAAGGAACAGATCGAG
+GACATCGTGATCGGCTGTACCAACCAGGCGGGTGAGGACGCGCGCAATGTCGCCCGCCAT
+GCCGGGTTGCTGGCGGGCCTGCCTGTGGAAACGGCGGCCCTGACCGTGAACCGCCTGTGC
+GGCAGTGGTCTTGCCGCCGTCGCGGACGCCGCCCGCATGATCACCTGCGGCGAAGGCGAG
+CTGATTCTGGCCGGGGGCGTGGAGAGCATGAGTCGTGCCCCCTTCGTCATGGCCAAGGCG
+GAGAGCGCCTATAGCCGGCAGTTGCGCACCTTCGACAGCACCATCGGCGCGCGCTTTCCC
+AATCCGAAAGTGCTGGCTGAATTCGGTTCCGATACCATGCCCGAAACCGCCGACAATGTG
+GCCCGGGACCTCGGCATCAGCCGCGAGGCTGCCGACGCCTACGCCCTGCAGTCCCAGCAG
+CGCTATGAAGCCGCCCGTCAGGATGGTTTCTACCGAGAAGAAGTGCTGCCGGTGGAGGTT
+CCCCAGGGTCGAAAGCAGCCGCCACGCTGGGTAAGCGCCGACGAACATCCGCGACCGGAT
+ACCGACACCGCAAAACTGGCTCGCCTTTCCCCCCTGTTTGAAGAGGGCGTGGTCACCGCC
+GGCAACGCTTCCGGCATCAATGATGGCGCCGCGGCACTGCTGATTGGCTCACGGTCTGTC
+GGCCAGAGGCTGGACATCAAGCCCCGCGCTCGCATCCTGTCTGCCGCCGCGGCCGGTGTC
+CCGCCACGTGTTATGGGCCTGGGCCCGGTCCCGGCTGCACAAAAGGCCCTGGCCCGCGCC
+GGTCTCAGTCTGAACGACATGGACATAATTGAAATCAATGAAGCCTTCGCCGCCCAGGTG
+TTAGGCTGCTGCCAACAACTGGGTATCGCGGGCGACGACCCGCGCCTGAATCCCAATGGC
+GGCGCCATCGCCGTCGGCCACCCCCTGGGCGCCTCCGGCGCAAGGCTGACACTGACCGCC
+ATGCGCCAACTGGAACGCATCAACGGACGCTACGCGCTGGTCAGCCTCTGTATTGGCGTT
+GGACAGGGCGTCGCGGCCGTGATTGAGAGAATGTAAGGCGTGAGGAAGTCAGGAGTCAGG
+CACAGAATTCACTACGCTTCTCCTTTCGCCTCACCCCCTAACCCCTAACCGTTGCAAAGG
+AGTCACCATGAAACCCTTCACCTGGGAAGACCCCCTACTCCTGGACCTGGCCCTGGACAG
+CGACGAACGCATGGTCCGCGACTCGGCCCACGACTACTGCCAGAACAAGCTCATGCCCCG
+CGTGCTGGAAGCCAACCGCCATGAGGTGTTTCACCGTGAGATCATGAACGAGATGGGCGA
+ACTGGGTTTTCTAGGGCCGACCATTCCCGAACAGTATGGCGGGGCCGGCGTTAATCATGT
+CTGCTACGGCCTGATTGCACGGGAAGTGGAACGCGTCGATTCCAGCTACCGCTCCGCCAT
+GAGCGTGCAGTCATCCCTGGTGATGCACCCGATCTACAGCTTCGGCTCCGAAACGGTCAA
+GCAGAAATACCTGCCCAAACTGGCCAGCGGCGAGTGGATCGGCTGCTTTGGTCTGACCGA
+GCCCGATCACGGCTCCGACCCGGGCAGCATGATCACCCGCGCCAAGAAGGTGGATGGCGG
+CTACCGGCTCTCCGGCGCCAAGACCTGGATTACCAACAGTCCGTTGGCTGATGTTCTGGT
+GATCTGGGCCAAGCTGGACGACACCATTACCGGTTTTGTCCTTGAGCGTGGCATGGAGGG
+CCTGGAAACACCCAAGATCGAAGGCAAGTTCTCGCTGCGTGCCTCTGTCACCGGCCAGAT
+CATGATGGATGACGTATTCGTGCCGGAGGAAAACCGCCTGGACGTCACCGGCCTGAAAGG
+TCCGTTCAGCTGCCTCAACAAGGCCCGCTACGGCATTTCCTGGGGCTCGATGGGGGCGGC
+CGAATTCTGCTGGCATGCCGCACGCCAGTACACCCTGGACCGCAAACAGTTCAACCGCCC
+CCTGGCCGCCAACCAGCTGATCCAGAAAAAGCTCGCCGACATGCAGACCGAAATCACCCT
+GGGCCTGCACGGCGCCCTGCGTCTGGGCCGGTTGATGGACAGCGGCGACTGGGCGCCGGA
+AATGGTCTCACTGCTCAAGCGCAACAACTGCGGCAAGGCCCTCGACATCGCCCGCACCGC
+CCGTGACATGCACGGTGGCAACGGGATTGCCGATGAGTACCACGTGATCCGGCATGTGAT
+GAATCTGGAGGCGGTGAATACCTATGAAGGGACGCACGATGTGCATGCGTTGATTCTGGG
+TCGGGCGCAGACGGGATTGCAGGCTTTTACTGGGTAAGGAGGTTAGGGGTAAGGAGGTTA
+GGAGTGAGGCAGAGGGTACAGTCCAATCACCTCCTAACCCCTAACTTCCTAACTTCTCAC
+CTCAAATCTCACATCGAAATACTCCCTTTACGAAACTCACTCACCGCCAACCGCAGATTG
+ATGCAAACCGCTGTCCCGGCATCGGACAGCTTGATCGCTTCCGCCAGGGCCGCGTCAATC
+TGATGGTTGTGCTCCACCAGGATACCGTGGCCACCGTAGCCCTCGGCGACCAGATGGTAG
+TCCGTGTCCCGCAGATCGGTGCCAACCGGGTCGCCCAGCATCTCCACCTGCTCCCGGGCA
+ATCTGACGCCAGCTGGCGTCGCAGCCGATGATGGCGATCGGGGCCAGGCCCAGACGGCGG
+TAGGTGTCGAATTCGGCCAGGCTGTAGGCGCTGGAGCCGTCGCCGTAGATCAGCCAGATG
+CGGCTGCCGGGTCTGGCTGCAGCCGCACCCAGCGTAAAGCCGCCGCCGACGCCCAGCGTG
+CCGTAGACGCCGGGGTCGAGCCAGGCCAGGGGGCCGCGGGGTTTTAAGGTGTAAGCCCCC
+GTAGCGACGAAATCGCCACCGTCCACGACCAGCACGTCCTGCTCCCCAAGATGCCGATCC
+AGTGTGCGGAAGAAATGCAGGGGATTGACCTTGTCGGCCGGTGCCGCGGCCTGTTGGTCG
+ATTTCCTCCTCGCGCGCGTTTTCGCGCTTACCCAGTTCACCCAGCCACGCCCGCCATTGC
+GCCGCGCGGCTCGACATCCGATCTGCCAGCGCCTGCAGAAAATCGCCGGGATGCGCCAGC
+ACCGGGACGGTGGGTTTGCGGTTGAGCAGCAGGTCATGGAGAGAGAGATTGACGGACACA
+AGGGTCGCGCCTTTGGCAAAACCCCGACCGTACTTGAGCCGGAAATCCAGGGGAAAACCG
+CAGACAATGACCAGATCCGCTTCGGCCAGTGCGCGGCCGCGGTGGTGGCGGAACAGCAGG
+TCATGTTCGGCACCCAGCAGCCCCCGTGACATACCACCGGTCCAGACCGGTAGCCCCAGC
+CGTTCCACCGCATCAGCGATGTCCTTCGCCTGCTCAGCGGTGCGATTCACCAATACCTGA
+GAACCCAATACCAGGGCCGGCCGCTGTGCCGAGGCCAGCCGCTTGACCACTTCGCCCAGC
+TGCCGGGCGGCATGCCACTCGGCCGCCGGCTCAGTCAATGTTTTCAGATTGGGGTGAACC
+GACAGGGCTGGCTGACGTTCCTGGCGCAATAGATAAAGATCCAGCCCCCCACGCAGCAGA
+CGGCCCACCGGCCCCTTCATTTTGTCCAGACCGGCCTGATCGGCATACAGGGAGTGCACC
+AGATCCCGCGGATACAGCAGATCAATCGGCGCCTCCACAAACACCGGGCCCGGCACCCCT
+TGGGCGGCCACTTCGAGGGCATAGCGCATGGCCTCATCCAGCTGAGCCAGGGTCCCCACC
+GATGTCTGCCATTTGACCAGCGACTTCATCAGCGCCAGTTGATCGATGTCCTGCAACGAG
+CCCCGGTTCTTCAACACCGTTGGCGTGGCGCCGCCAATCACCACCACAGGCGACTGGGCC
+ATCTGGGCATTCTTGAGCGCGGTGATGGTATTGGTGACCCCCGGACCCGCGGTGACTGCC
+GCCACACCCGGGCGCCCGGTCAGCCGCGCCATGGCATCAGCGGCAAACACCGCCGAGGCT
+TCGTGACGCACATCCACCACCTCGATGCCCAGCGCCTTGGCCTGCACCAGAATCGGCGAA
+ATGTGACCGCCACAAAGGGCAAATAGATGGGAAATGCCCGCCGCTTGCAAATGCTCGGCA
+ACGATTAATCCGCCATGCTTGCGTTCAACCATCGCCAAACCTCCTCACCCTCAATCCACA
+ATGGCCCCATTGATGATCGACCTCAACTCCTGGCGGATCGGATAGGTCGACGAGGGAATC
+AACTGGGTCATGAACACCATGATCAGGTCTTCCACCGGATCCACCAGGAAATTGGTACTG
+GCCAACCCACCCCAGCCGTATTCGCCCACCGAACCGTTGGTCTGGGATTTCGCCACGTCC
+ACCTTGACCGAAAAGCCCAGGCCGAAACCGGAACCCTCGTAGGGCGTCTCACTGAACGGC
+CCGATCGACAGTCCCGGCAGATCCTGGTTGCCGGGGAGATGGTTCATGGTCATGAAATCC
+AGGGTCTTGCGGCCGATAATGCGGGCGCCGTTCAACTGGCCCCCGTTATTCAGCGCCTGG
+GCGAAGCGGTAATAGTCATCCACGGTGGACACCAGCCCACCGCCGCCGGAAAGAAATTTG
+ATCGGGCGAGTGAAATGGGAGTCCGCGGGATCATCCTGCAGAGCATAGCCCTGTTCAGGA
+TCAAACTGATAGCAGGCGGCAAAGCGCTCACGCTTGCTCTCCGGCACCATAAAGCCGGTG
+TCCGCCATTTCCAAAGGATCGAAAATATGTTCCCGGAAGTACTCATCCAGCGGTCGGTCC
+GACAGCAGCTGCACCAGATAACCCAGCACATCGGTGGCCACCGAGTAATTCCAGGCACTG
+CCGGGTGAGAATTCCAGCGGCAACTGGGACAGGCGCTCGACCAGCAGGTCCAGCGTCATC
+TCCTTGCCCCCATCCAGCTTGAGCTCACGGTAGGCCGCATCCAGGTTGGTGCGGCACATG
+AAGCCGTAAGTCAGCCCAGACATATGGGTGAACAGGTCACGGATGGTCATGGCCCGCAGG
+GTTGGTGTGGTCAGAAACTGCGGATAGACACCGCTCTGATACACCCGCAGGTTTTTCCAG
+GCCGGAATGTATTTGTGCACCGGGTCGTTGAGCAGAAAACGCCCCTGCTCGAACAACTGC
+ATCATGGCGATGGAGGTGACCGGCTTGGTCATGGAATAGATGCGGAAAATGGTATCCCGC
+GCGACGGGCTTGTTCCGTTCCACGTCCATCAGGCCCTGGGCCTTCACGTAAGCCACCTGG
+CCCCGCCGGGCCACCAGCGTCAACGTCCCCGGCAGCCGTTTGGGCTTGAGATATTTGCGG
+TCGATATGCCGCTCAATGTTGTCCAGCCGCTCCAGAGACAAACCGGCAATCACGTCAGAA
+CGCCCCATTACCTTCCCCCTATCCAACAAACAGGCATGCCAGCTTTGCGTATTGCTCAAG
+GGTCAGGGGGGTGGCCGATTCGGGACCGTCCGAGGCCAGGACGGCCGAGGTCGAACTTAC
+AGGGACGTATTTACAGCGTGTCCCGAATCGGCCACCCCCCTGACTCGAGTTACGATACAG
+GCACTCTCATGCCTCATCATCACTGAATCGATGATCCTTGAAATCATCCCGCAACTTGGT
+TTTCTGCAGTTTCCCTGTCGCACTGTGCGGCAGCTCATCCACAAAAACCACATCATTGGG
+CAGCCACCACTTCGGCACCCGCTCGCTCAGGTACTCGACAATTGCTTCCGCCGTAACGGC
+CGAATCCGGATTGCGCACCACCACCAGCAAGGGACGCTCCGCCCATTTACTGTGTCGCAC
+CCCGATCACGGCCGCTTCCGCCACTTCCGGATGCCCGACCGCCTCATTTTCCAGATCGAT
+GGAACTGATCCATTCACCCCCGGATTTGATCACATCCTTGACCCGGTCCACGATCTCCAT
+GTAACCATCTGGATCAATGGTGGCCACATCGCCCGTGCGGAACCAGCCCTCATCGTCGAA
+CGCCTTGGCATTGGCCTCGTCATTGCGATAATAGCCGCTGGTAATCGCGGGTCCGCGCAC
+CAGCAGTTCGCCACGGGCCTTGCCATCACGGGGAAGCGCCTTGCCGTCGGCATCGACGAT
+TTTCATTTCCACCCCGAACAGTGCCCGGCCCTGCTTGCCACGCACCGTCAGCTGCTCTTC
+CGCCGACATCCGCTCTCGCATGAAGGGCGTCGGCTGGGAGACGGAGCCGACTGGGCTCAT
+CTCCGTCATTCCCCAGCCCTGAATCGCCTCAACCCCATAGCGCTCCTGAAACTCGTTGAT
+CATCGCCCGAGGCGCCGCCGAACCACCAATCTGCACGTGCTCCAGCTTGGAGAACCGCTC
+ACCTGACTCATTCATATGCCGCAGCAGCCCCAACCAGACGGTCGGCACACCCCAGGCGTC
+GGTCACCCCCTCGCTGTTGATCAACTCCGCCAAAGAAGCACCGTCGAGCCTCGGCCCCGG
+AAACACCAGCTTGGAGCCGGTGATCAACGCAAAGTAAGGCATGCCCCAGGCGTTGACGTG
+AAACATCGGCACGACCGGCAACAGTGAACTCTCCTCGCCGAAATCCACCCCCGGGAAAGC
+CATCACGGAGAAGGCGTGTAACAGTGTGGAGCGGTGGGAATACAGCACGCCCTTGGGATT
+GCCCGTTGTGCCCGAGGTGTAGCACAGGGACGACGCCTGATTCTCATCGAATTCCGGCCA
+GTCATAGCGGGTCGGCTGGTCCTTGATCAGGGTTTCATAGCAGTGGGCATTTGGCAGCCC
+GGTTTCCGGCATATGGGCCTCATCAGTCATGATGATGTAGCCCTTGATGCTGTTGAGCTG
+GGGATGCAGTTTTTCCAGCAGGGGGACAAACGTCAGATCCACGAACAGGTACTGATCCTG
+CGCGTGATCGACAATGAACTGGAACTGCTCCGCCGGCAAACGCGGGTTGATGGTATGACA
+GATGGCACCCATACCGGAGACCGCATAATAGATTTCCAGGTGACGGTAATTGTTCCAGGC
+CACCGTGGCAACACGGTCATCCTGAGTGACGCCAAGACCTGCCAGGGCATGGGCCAGCTG
+GCATGACCGGTCCCGCAGTTCCGGATACCGGTAACGGTGGATGGGGCCTTCCGTCGTGCG
+GGAAACGATTTCCTGTTCCGGATAATTGACTGCGGCGTACTCCAGGATCTGGGAGATCAG
+GAGTTGCCGGTTCATCATCAGTCCATGCATCATCTACCCCCTTTATTGGCAGGCCATCCT
+CAGCGCGCGCTGACGATCGCCATGGTGATTCTTGAAATACAGATCAGTCGATCCTGCTCG
+TCTTGGATACGGATTTCCCATACCTGGGTAGCGCCTCCGATATGGAACGGTCGGGCCGTG
+CCATAGACCCAGCCCGAACGGGCTGAACGTATATGATTGGCATTGATTTCCAGGCCCACG
+CCCGCCTTGTCGGGATCGGCAATGCACAGGTTGGCACCGACGCTGCCCAGGGTTTCGGCC
+AGCGCCACCGAAGCCCCGCCATGCAGCAGACCAAAAGGCTGATGCGTGCGCTTGTCCACC
+GGCATCCGCGCTCGCAGGAAATCCGGCCCCAACTCCAGATACTCGATGGCGAGGTGCTCG
+ACCATCGTGTTCTTCGCATGCGCATTCAATGCTTCAACCGTTGCCGGGCGCTTCCAGATG
+GGCGCCTTCTGATCGGGATTCTGGGTCATTCACTATTCCTCGTTACTACCTACCGTTACT
+ACCTACCGTTACTACCCACCGTTACTACCACCGGCCCTCGTTAAAACCACCGGCTCAGTG
+CGTACCGCCTTAACCCTGCAGCTTATCACGGAGCATCTGTCCAATCTGGGGCGCCTCGGC
+GAAGGGATCACCCGGATTGCGGCCGGCCACGATATCCTCCATACGATGTTTTACGTTACC
+CAGGGCTTCCGGATGGGAGTAGATATAGAAGCGGTCCTCCCCAATCGCCTCGAAAGTCCG
+TTGCGCCACTTCCGCTGCACTCACCTTGCCCGAGGACACCGCCTTCTGGGACATGGCCTG
+GGCAATCATCTGGCTGGCCGTGGGGCCACTGTCATTCTGCAGCTCGGCGGGGCGGTTGCG
+GTGGGAATCGCTGATACCGGTGGGCACGAAATAGGGGCACAGTACCGAGGCACTGATGGG
+GGCGTTGACCAGCTTTAAATCCTGATAGAGGGTTTCCGACAGGGCCACCACCGCGTGTTT
+GGAAACGTTGTACACAGCCATGGTGGGCGGACACAGCAAGCCGGCCATGGAGGCGGTATT
+GACGATATGCCCCTCATAATCCGTCTCGCGCCTGGCGGCCTCCAGCATCAGCGGCGTGAA
+GATCCGTACCCCATGAATCACGCCCCACAGGTTGACGCCCAGGACCCACTCCCAGTCCTG
+CTCGGTGTTTTCCCAAACCAGGCCGCCGGAACCGACACCGGCATTGTTGAACACCAGATG
+CACCGTGCCAAAGCGCTCCATGGTTTTATCCGCAAGCGCCTGAACCTGCTCGCTCTTGCG
+CACATCGCACAGCATTGCCAGCACTTCGGCACCGGCTGCTTCCATCTCCGCCCGGGCCTG
+CTCCAGCGGCTCTGCCTGGACATCCGCCAGCACCAGTTTCATTCCCCGTGCCGCGCCCAC
+GCGGGCAAACTCCAGGCCAAAGCCGCTGGCCGCGCCGGTAATGACCGCAACCCGGTTCTG
+CATCTGTTTCATAGGGCCCCACCTCTTGTCATTTGTTCTGTAAGCGGGTCCTTTCACCCA
+CATTGCCTGCATGGCAATCTGGCATGGACCTGTCTTGAGGTCAACTTTTTGGAATGCTAT
+TTTGCTAAGCGAAATTCAGCAACATCAATCCACCAAAGGAAAGCTGTCCATGGGTGAACT
+CGTCGACGTCTACCGCAACAGTGTCCAGACCTGGGAATGCGACCAGATGGGCCATATGAA
+CGTTCAGTTCTACCTGGACAAGGCGGACGCGGGTCTGCTGGCCCTGACCCGGATGCTGGG
+CCTGAACCGGCGCTTTCTGAATGAAAGGCAGGCACGGGTGCGGGTGCTGGAAAACCATGT
+CCGCTTCCTCAGGGAGCAGCATGCCGGCAGCCCGCTGACGCTGCGCGCCGGGCTGATCGA
+TATTCGCCCTGACCAGCTGAAACTCTATTTCGAACTCACCAATCCGATCCAGCAAGCCGT
+CGCAGCCAGTTTCATCACCCAGGCGGTGCTGGAGTCCACCGCCGGCAAGGATCATCTCAC
+CTTACCGCAAAGCGCACTTGAAAAGGCGCAACAATACCAGATCGACTGGCCGCGCCCTGA
+AGGCCCCATGGGGCTCGAATCCACCCCACCCCGCACGCCACCCACCCTTCAGGAAGCGGA
+TGACCTGGGCATGATGCCCACCTATCTGGGCGCGGTTTCAGCAGGCATGTGCGATGCCGA
+TGGGCACCTTGCCATCCGCAGCTATATGGGCATCGTCTCCGACGCCGTCCCCCACCTGCT
+CTCGCGCATCCGCCATGATACCCGTGAAGTTCCCCGTCCCGGCGGTGCTGCGCTGGAATA
+CCGCTGGATCTACCACCAGCGCCCCGAGCAGGGTGACCTGGTCACCCTGCGCAGTGCCAT
+CACTCATCTGGGCAACAAGGCCTACCGCCTGGGACACTGGCTGTTCGACGCCGAAACCGG
+TCACTGTCTGGCAACGACCGAAGCGGTGGCAGTGATGATGGATCTGGATGAAAGAAAGGC
+GCTGGTGATTCCGCAAACGGCCCGGGCGTCGCTGGAGGAAATGCTGGTAAAAGGCTTTTC
+CATCTGAACACGTAATGGCGTTTGCATCGTCAGCCTCCGGGCGCGCCGATGATTCTGGCG
+CTCCCGGTTACAAGCTCATCGTATAGATCAAGTCGCCCTTCTGCGCTGCCTGAACTTTGA
+TTCCGGCCCTTGGTCTTTGATACAGGTCGTCGGTCATGCCTGCATTGCCGGTATGAGCAC
+CTCCCGGACAGGTCGGGTGGGCGCGATCCTCCCGATGCCTGTATCTGCGGAGGTGAGCAT
+GAAAGCTGGCATGGTGGCGCCATTGGATGCGACGCAGCAATCCAGACTGCGCGTTCTTCT
+CGCACTGTTCGGCCTGGTCTGGCTGATCAACGCAGGTTTCCAGGCCGTGGCGTGGCTGGC
+CGCGCCCAATGCCTCAACCCATTTCATCCACGCGCTCGCCAAGTCCACGACGGTGGTCCC
+CCGGTGGGTTCAGCCCTTGCTGATGACAGGGCTGCACAGTGCGCAGTCGCTTGGTCTTGG
+AATCGTCGCCGCCATCATGGTTCTTTTGGCGATCCTGCTCGGCCTGGCACTGCTGACTCA
+AAGAAAAGTCGCGTTCGCAGCGCGGGTGGGGATCATTTACAGCATCATCTGCTGGATCTT
+TCTGGACGGCTTCGGTTTTCCCTACGCCAACGGTCAGACCGATCCCGGCGTTTTTGTCGC
+CTATGCCATCGCCTTCCTGTTTGTATTATCCGTGGCACCGGTATTTGACAGAGAAGGCAC
+CAAGGCCCCTGAAATCGACGAGCGTCTGTGGCATTGGGCCCGTATCGCGTTTGGTCTGCT
+CTGGTTGTTCGATGCCGTATTGAAATGGATCCCGCCGTTCCTGCTCCATTTCAGCAGCCA
+GATTACGTCAGTGATTCCGGGCCAGCCGCACTGGATCGCGGCCTGGCTTTCGTTTGTGGC
+CGAACTTGTCCATGCGATCGGGCCGATTCCGGTTGCGGTGGTGGTGGCGCTGGCCGAGAC
+CGCAATCGCGATCGGTTTGCTGAGCGGCCGATGGATGCGCCTTGTGATTCCCGTCGGCAT
+GCTTTATTCAGTGGCGGTATGGACCACCGCCGAGGCCTTCGGCGGACCTTACTCGACGGC
+GGGGACTGGCGTGCGTGGCAACGTTCTCGGTAATGTTCTGATCTACCTGATACCCTTTCT
+GTTCCTGTGGGTAGGCAATAGCTCCCAACGAAGCGCAGCGGAAACCACCGGCCGCACCCT
+GACAGACTGACACTGTCTATTGCTGGCCGGACACCAATAAAGTGCAGTGACCGATCAATT
+CCAGCCCATGGCTGTCTGCCATGACTTGATCCAGTCGGAATAACAATGCCCCCCATAGAT
+GACGCCCCCGCCCAAGCGCTGCTATCATCATAAATAGCAACTATATCGGGTCATAAATAA
+TATTTATTTAGGCTAGCCGTTCATCTAAGCATCCCCGATGGGCTTTCCATTGTTTGTCGC
+CTGTCCGGGTTGGGTACTGTTATGGTCAAGAAAGCACCTGAAGTCGACGTTCCATCCGCG
+AAGGACCGTAATTTTGTCACCGCCCTGGCACGCGGCCTGGAGTTGCTGCGTGCGTTCGGG
+CCTGAGGATGATTACCTGGGCAACGCTGAACTGGCTGAGCGCACGGGGATTCCCCGTCCT
+ACGGTTTCCCGTCTGACCTATACCCTGATAGAACTGGGTTATCTGCGTTATTGCGAGCGT
+CTGGAGAAATATCGGCTGGGCGCGGGTGTGCTGGCACTGGGGTATCGCTACCTTTCGCGG
+ATGGGACTTCGCGAACTGGCCCGTGGACCGATGCAGGCGCTGGCGGATCGTACGGACTGT
+CTGGTGGCCCTGGGAACGGCCGATCGCCTGGACATGACATACGTGGAAACCTGTCAGGGC
+GCCGGACCGCTGGTGTTGCGTCTGGAGGTGGGCTCACGCATTCCCATGGCAACCAGTGCC
+ATGGGCCGCGCCTACCTGGCTGCACTGCCGGATGCACGCCGGAACGAGTACCGGGAGAAA
+ATCCGCGAGGTCTATACCGATGATTATGAAGCCATTTGGCAGGGGGTCGAGCAGGGGGTC
+GAGCAGTATCAGAAGCTCGGGTTCTGTACCGCGCTCAGTGATTGGAACCCACATATTGCC
+GGTGTGGGCGTGCCTTTGGTGCTGGATGGCGGCAGCCAGATCATGGCCTTCAATTGTGGC
+GGCGCGGCGATGCGCCTGAGTCGCTCAGTGCTGGAGAAGAAGCTGGGTCCGCAACTGGTG
+GAAGTGGTGGCGGAAGTACAACGCCAGATGCATGGACGGCGCCTGGAGGCGGTGTCCTGA
+TATAGCAGGAACGATGGAAAAAACGGCGGGCCAAGGCCCGCCGTTTTCATTGGTGGTTTA
+GAAATCCCAGGTCATGCCCAGGGACAGGGATTGCGGATTATCGCCAGGATTCAGCGGATA
+GACGCTCTGTCCATGGTTGGGTCCGCCCAGGCCGTATAGACCTTCGGCATTGTTCCGGGT
+GTAGGCATAAATCAGGTAGGCCGACACCTGCTTGTCGAAGTGATGCTTGATACCCGCCAC
+GTATTCGTTGGCACCGGACTGCTTGACTTCGCTGCCGCTACACACGGTCTTGGTGGGATC
+ACAGATATTGGCCAGGGGCGAGCTGAGGTTGCCGGCATGAATCCAGCTGACCATCAGATC
+GTTGTTACCCGGCACCGCCTGACTGAAGCCCAGGCTGTAGGCATCGCGCGAATACAGACC
+GGTTGAACGCTCCCACACGGCAATCGCCGTGGTTCCCGTCGGCTCATAATCCCACTTACC
+TGCCAATTCCAGAGCTTTCAGCTGCAGCTTGCTGCTGGGGGGCGTCTGGTTCGGCTGGGT
+GGCGTCGGCGAAAGTGAATCCTCCAAGCGGCACTCCCGAGGTGTTACCCTGAACATTGAT
+CTGACTGTAGTTGATCAACCCGTTGACCTTGCTCTGCAGACTGGAGAATTCGTTCTCATA
+CTGAACACCAAACGACCAGGCATTGTTATGCTGGTTGGCGTTGGGGTAGCCGTAACAGTT
+GGGGTAATGGTTCGTGTTCGGGGTACCCGCACAATAGCCGGACCCATAGGTATTATTGGT
+ACCAAAGTCCCCACCGTTGGCATCCTCAGTGTATGAAAGGACCGCATCGAACCCCTTCAC
+CTTGGGACTGGCATAGGAAATGGCGTAGTTGGCCTGCCCGGCAAAGCTGATTGCGGGTAG
+ACCGTTAGGGCCACCATTGGGGAAATTTGCGGTATCGATGATGGAGTTAAAGTCACCCAC
+GGTGTCCTTGAACATGTTGAACGGCCGCGAGAGGTATGCACCCTGGTTCTCGAATGAGGG
+CTGGAACAGCAGCGTGCCCAGAGGATTGGCAATACCGAAATAGGTATCGTGCAGGCCCAC
+GTTCTTGCTCACATGGTTGCCCTTGCCATAACTGTTATTGACGCCGGTCTCACTGCCGGG
+CAACGCCAGTTCCACCTGGAAAATGGCCATGAAGGCGCCCGGCACCAGATGCTGGCCGGT
+AAAACCGATTGTGGAATTGTTGTTGGAGAGATTAGTGGCCCGTGCCGGAGTGCCGGCGGC
+TTCGCCGTAGGCTTCGGTATTGGGCACGGCACGACCGCCGGTATTGGAGAAATCCACCGA
+ACCGTGCAGGTGTGCATGCAGTTTGATATTCATATCAGGCATGGAGCTGGAGCTGCCGCT
+GTCCGCTACCGCCACCGCCGGTACAGCCATCAGCCCTGCCAACAGGGTTGCCAGGTATCG
+TCTCTGCATTTTTGACATCCTCTTTTGTGTTTATTTTCGAGTCTGCTTCCATGCAGCTCC
+CATCCCCCACGGATGAGAGTCCACTCGCCGTTCCTGGCCAGGTTCCAGCTGCGCAAGCCG
+CTCAACCGGCGGCGCGCTCGCGTTCCTCCTCCTGCAACACCCGCCACTGGATCTTGCCGG
+TCGCCGACCGGGGCAGGCTGTCACGAAATTCGATGATGCGGGGTACCTTGTAGGCGGCCA
+TGTTGTCCTGGCACCACTGCTGGATCGCCGCTTCGGTCACATCCGCGGGAGCATCGTCCG
+TCAGGACGACCACCGCCTTGACCGTCTCGCCCCGACGTTCATCTGGCGCGGAGATCACAC
+AGGATTCGCGAATCGCCGGGTGCTGGTACATCATGGATTCCACTTCAGCGGGCCAGACCT
+TATAGCCGGAGGCGTTGATCATGCGCTTGACCCGGTCCACCAGGTAGAAATAACCCTGCT
+CATCGTAATAACCGAGATCGCCGGTCCGGAAGAAGGATTTGCCATCGACCTCAGTAAACG
+CCTCGGCCGTGGCCTGGGGCCGGTTCCAGTAGCCTTTGAACACCTGCGGACCGTTAATCA
+CGATCTCGCCCACCTCACCGACATCCTGCTGCTGGCCGCTGGCCACATCGAGCACGCGGC
+AGTCCACATCGAAGACCGGGATACCCAGGCACTGGGCCCTGGGATTGTCGACAGGATTGA
+CGTGAGTGGCGGCGATGGTTTCCGATAATCCATAGCCCTCGATGTAGGTCAGACCGGTCA
+TCTCGTGGAGGCGCTCAGCGATCGCCTTGGGCATGGCTGCTCCCCCACCGCCAATGGCAC
+GCAGGCTGGAAAGATCGTAGTTGCGGGCTTCAGGGTCGGACAGGAAATCGATCACCATGG
+TAACGATATTGCGCCATTCGGTAACGCCGTAGCGCTCGATCAGCGCACCGGCGACCCGCC
+GGTCCCAGCGGGTCATGATAACCATGGTCGCGCCCACAAAGATGGGGGCGTTCATCGACA
+CCTGCATGCCGGTGACATGGAACAGCGGCAGACTGACCAGGGTCACCGAATCGGCTGTCG
+CGGGGTTCCAGGCAACGGCGCCCACGAGGGTCGCCATGACGCTTTGATGGGTATGGATGC
+ACCCCTTGGGCGCGCCGGTGGTGCCGGAGGTATAGGGGAAGACGCAATGGTCCTCCGGCC
+CCACCAGGGCCTTCGGGGCCGCAGGTTCCCCGGCCAGCGCCTGCCGCCAGGGAACAACAC
+CGGACTGGTTGATCGCCCGGGCCGGTTCACTGACCGCATCCGGCAAGGGCAAGTCCGTTT
+GATCGGGAAGGTATTCACTGTAGGCCGCCACCACTGCCCGGCTCAGACCTTCCTCACCCA
+GCAGTGGCGAAACCTGGTCGAACAGTTCCTGGGCACAGAGAATGACACGCGCCTGCGTGT
+CCGAGGCGTAATGCTCCAGCTCGCCACGACGGTTCATGGGGTTGACCGGCACGACCACCG
+CATTGGCCCTCAGAATCGCGTAGTAGGCAATCATCCACTGCGGGGAGTTCTGCATATACA
+ACAGCACCCGGTCGCCCTTCTCCACGCCCATTTCGCGGGCCAGAAAACCGGCCAGGATCT
+CGACCTGACGCTGGAATTCGCCGTAGCTGATACGGCGGTCGTAAAAGATGATGGCATCCT
+TGTGGGGATAGCGGTGAGCGGTCACTTCCAGGTTGTAGCAGATACTGGTTTCCGGCAGCG
+TCAAGTGCAGCGGAGCGAACTCGGGCCATACCTGGTGATGGCGATCAAACATCGAATTTT
+TTCCTCCTCTGGGCCCAATAAGCGGGCACTTGTTCTTGTATCGAGGAAAGACTCTTGTTC
+GTAAAAGTCTCGGGACGGGAAAAGTTCCGAGGGCGTTGTAAGGAAACGGTTTTTCCTTGT
+GGCCCGGCCAACTCCCTGTCTATATTGGCCAATCTCGCATGGAATACTCAGGGCGTCAAT
+ATTTTTGGAATTTAATTCCGCAGAGCAGAATAAGGGAAAAAAGAATAGAAACCAGATCAC
+GGAAACGGCATTCCAGGCTCCGCCCTGAAGTGCAAGCTGGGTACGAAGACATTGAGTTGA
+AGATGACGCTACAGGACCCCTGTAGACAAGGGGCCTGCTTAAGCAGGGTCAATCTGCCCT
+GTCCCCGGACTCCTGCGGGGACCAGGGCAGAAGTCCCTATTGGGACTGATGCTGGGATTG
+TTTGCGGATGGTGCTGCGGGCAAGGATATTGATGAGCAGGGCAAAGCCGGTGGTCAGGAG
+CGCCGCCACATAGGCCAACTGGTGGGCCGCGCTGGAGGGTTCGCTGATAAAACTCCAGAT
+GACGTAGGTCAGGTAGCCCACCGGATGGTGGAAGAACTCGCCCCCCCACATGTAGTTGGA
+CCATCCCAGCGTGTAGATCAGCGGCGCCGTTTCGCCCATCGAGATGGCGGCGGCGAACAG
+CAGACCGTTGAGAATCTGGGGAACACAGCTGGCCAGCACCACCCGGAAAATCACCACCCG
+GTCACCGGCACCCAGCGCATAGGCTGCCTCCCGGACGCTGTTGGGGACCTGCAGCAGGGC
+CAGCTCGCTGGTACGCGCAATGTAAGGCATGATCATGAACGATAGCGTGATGCACCCGGC
+CAGTAACGAGAACTGCCAGCCAAAAAAGTTGACCATGGCGATGTAACCAAACATGCCCAG
+CACAATGGAAGGCACACCGATCATCACATCGCACAGGAAGCTGAAGAATCGGGCACTCCT
+GCGGTGCTGATACTCGGAGAGGTAAATGCCGGTGACCACACCCACTGGTGCAGCAATCAA
+CAGCGAGCCCACTGTCACCAGCAGCGTCCCCTCAATCGCATTCAATAGCCCGTGGTACCC
+CTGGGTGGTCTGCGACAGGGTGGCCCAATTCACGTGAGCACCACCGCGAATCACCACAAA
+GGCGATGATCGCAATCAATGCCAAGGCCAGCAGAGCGAACATCAACGCCGTGCTTCCCCA
+ACCCAGCCCGCTCAGAGCAAGGCGCAACCGGTAGCCACCGGCACGGGGCCGATCAAGTCC
+GGAGTTGCTGATTTCATCGCTGGAATATTGCATGGTCAGGGCCTATTAAAATTTCCCGGG
+CATTCTGCTTCGAGCCAGACTCCACTGCGGGTGCGCAGCTCGGGTTCATTTGCAATCAGT
+CGCGTGCCAGCCACAACAGGAGCCGGGCAATGACATTGACGATCAGCGTGATGAAAAAAA
+GGATCAGTGCGATTTCCGACAGTGCATGCGTGGCCATCCCCGAAGCGTCTTCCAAAGCAC
+TGTCGAGCTGGGAAACGATGAATGCCGCCATGGTGGAAATCGGGCTGTAGATATTATGAG
+GCAGATAGCCCAGGGCATTGCCACTGACCATCAATACCGCCATGGTTTCGCCCAGGGCCC
+GGCCCAGCGCCAGAATGCCGGCACCAATCACCACCCGGCGCACACTGGGCAGCACCGTTT
+TCCAGAGCACTTCAAAACGGGTGGCGCCCAGGGCCAGCCCCGCTTCACGCTGTACCATCG
+GCACCCGCTCAATAGCGCCACGGACCGTGGATGTAATCAGTGGTGCAATCATCACCGCCA
+GAACCACCGACGAGGTTAAAAGCCCGTAACCGGCGCCCGTCGGCGGTTGAAAGAAGGGGA
+CATCTCCCAGCACATGCACCAATCCGGGGTAGATGTAATGGTTCATGAAGGGCACCAGTA
+CCACCAGTCCCCAAAGCCCGAATACCACACTGGGTACGCCGGCGAGTAATTCCACGAACA
+GGGCGAGCGTATTCTGTAAACGCTTGGGTACCGCCTCTGCCAGAAACGCCGAAGCCGCCA
+CGGAAATCGGCAGCGCGATCAACAGGGCGAGAAAGGAACTCAACAGGGTACCGGCAATCA
+GAAAGCCGATGCCGTAATCGGCTCCTGGCGGCACTTCCTGGCCGTTGACTGTCACCAGAT
+CGCCGTATTCGTTGCCCAGTGACCATTGGCTGCCGGTCAGAAAATGCCAACCACTGAACT
+TGATCGCAGGCCAGCTGTTGATCAGCAGAAAAATGAAAATGGCCAGTAGTGCCAGCGGGA
+TAACCGACGCGATACCGGTAATCGACCAGCGAAAAAGCCGATTTGTTTTCATCAAACCAC
+TCCACTCACTTGGGTATGCCAGATACAAACAGGGTCCGACTGCCCCAAAGCAGCCGGACC
+CGGTACATCCCAAGGTGGATCAGCTGTGGATCTTGGCGATCTGCGCCTTGGTCAGCTCTT
+CAGCCTTCTTGGGCAGCGGCATGAAGTTCACAGCGCCCAGGTACTGACTGGCGTTACCGC
+CGTTGGGGCTGACAGCCCAGTTGAGGAACTGCTTGAGCGGCGCAGCCAGGTCACCCTGGT
+TGGCGTGCATGATCACATACTCATAGTTGATGATCGGGTAGGACTTCGCACCCGGCGCAA
+AAATCAGGCTGATGCGCTCATCTTTCGGCGTTTTGGGGACCATGGCGGCGGCAGCAGCCG
+GAACCGTGGTGGAGTTGGGCAGTACGAAGTTGCCAGCTTTGTTTTTCAGCATGGCTTCGC
+CCAGGTTGTCCTTGTCAATCTGGCCCTTGTAGCTGACACCGATGTAGGCAACGCTATATG
+GGTTGTCCTTCAGTGCCTGAACCATGCCCGGGTTACCGGTGGCACCGATTTCACCCTGAA
+CCGCCGGCCAGTTGACCGTGGTGCCATAGCCCAGCTTCTTGTGCCAGTACGGATGACTGA
+ACGACAGGTACTGGGTGAACAGGAAGGTGTCGCCACTGCCGTCGCTGCGATGAACCGGCA
+CGATGCGGTGATGGGGAAGATCCACACCCGGGTTCATGGCCTTGATTTCCTTGTTGTCCC
+AGTACTTCACAGTACCTTCATAGATGCGGGACAGAACCGGACCGCTCAGCTTGAGGTGCT
+TGTCGTTCAGGCCGGGAACGTTGTAGTTCACCATCTGGGAAGAAATGGCCACCGGGATAT
+TCAACATATCCGAGTGCTTCTTCATCATGGCGCCGCTCAGGTAAGCATCAGAGCCGCCCA
+TCTGCACGTTGCCGGCGATGGACTGGGCGATGCCGGTGCCGCTACCGGTGCTGGCCGCGT
+TTACCTGAATATCAGAGTGGGCCTTGCTGTAAGCCGGAATCCACTGGTTGAACAGCGGGT
+ACAGCAGGCTGGAACCGGTTTCCTGCAGGGTGGTGGACGCATTGGCAACGCCCATACCAG
+CGGTCAGCAGTGCAGCAGCGAGCGCGCCCTTGGCCATCATCGAGCCGGTACGGGTGCTTT
+TCAGACTGAACTTTCCTTTCATCTCGTTACCTCTATCTGTGCTTTGAGTCATTCATTCGG
+GCAAAAACAACGACTGGCCGATCTCCGCTTCCCTACAGCCGACCTGGGTGGTTGCCTATG
+GATTGAATCCGTTTGCAAAGCGCAACGCCGCTTCCTGAACGGCAACTTGCGGTCTCTGCA
+ACGCGGCAAAGAATGCACCTCAGGCAATGACAGTTTCGTGACAGCACCGGGGCCAAATTG
+ACCTAGGAGTCTGCGCGGCAGAAGTATTTTAAGCCAGCACTCCCACAACACCTGACAACG
+GTGTGGGCTCATGGTCGCGGCCGCCCGAGATATCCAGCCAGGCTAAATGTCGGTTTACCG
+CCGTCGCCTTGGCTACAGGCAAGGTGACAGCTGTACATTGTGCACTCTATACGTCCAGGT
+ATTCTCAGATTTTCTACACCATTCTCATCAATGTGCTCATTCGCCTGAGGTTGAGCGACA
+GGCAGACCAGATCCCATTCACCTTGTACCGCGTTGAGACCTCGCAGACTGAACTGCCGGA
+ACCCCAACACATGCTTGATCCAGCCGTTGACCGCTTCAACCAAGTGCTTGCGCTGCCCAT
+AAACGGATCGTCCGGCGGCGGTGGCCAGTTTCTCCGCCATCCGCGCCGTCGCCGGATACC
+GGGTCGCGTCTATTTCTCCGGGTTTCCTACCTTCCCGCCGCAGTGACACATAACCATCAA
+TGCCGTTGACCTCCAGCGTCTGAAGATCACCCTCCTTACGGTAGCCGGCATCGGCCAGAC
+ACTGCCGGGGATAGGTGCCCAAGGTGTCTTTCACGTCGTTCAGTAAGGGCAGTAGACAAC
+CGTTATCACTGGGATTGCTGCCCTGATGATTGGCAACAATAAGCTGGAACTCACCATCAA
+CGGCCAGCTGGCCGTTGTAGCATTGCTGGAACCCATCCGATGTTTTCATAATCCGGCTTT
+GGGGATCGGTGAAGTTACTCTGATCCTTGTCGTCCGGTACCCCGTAATCCCGCTTGAAAT
+TCCGGCCGCCACGGGGTGAGCGGCGATCGTCGTCCGGGGATCGGCCCCGGGCCTTGTCTC
+GCTCCTTCTGGTCCGCTTCCAGCTTCTCCTTGGCGGCACGGATCTTATCCAGTCGTGCCT
+GGCGGTGCTGAAGCTCTTCAGGGAGTTCATCACCGCGTTGATCCGGGCCGAACTGCTGAT
+CTTCCTCTTCATCCGTTCGACGAGCCTGGCGGCACAGCTCATCCACCTCTTTGGACAGGC
+GTTTTTCTTCTTCCTGCATACGGCCATAACTCATGGCTTTGTGCTTGCTGGCATTGGCCC
+GAACCTTGGTGCCATCAATCGCCAGCGTTCCCAGGGTGATCAGCTCTGCTTCTTGGGCGA
+TCCGGACGACCTGAATAAACACAGCCTTGAACGCCGCCAGATGCTGTTTGCGGAAATCGC
+AAATGGTTCGATGCCTGGGAAAATTGCCTGCTGCCAGTACCCGGAAGGCCACGTCCTCTT
+CCAGCTTCCGGGCGATTTTGCGGGATGAAAATGTGCCCGTCGCGTAGGCGTAGATCAGAA
+CCTTCAGCATCATCCGTGGATCGAAGGGGGAATTGCGCCGGCCGTCCCCGTCGTAACGGG
+CATAAAGCGCACTTAAATCCAGCTCCTCGACGACATCGCTGACAAAATACGCCAGATGGC
+CTTCAGGCAGCCACTCGTTCAGGCTTGGGGGGAGGAGCAATTCCTGGTCGGGAGAATACG
+GGCGGAAGGTGGTTCCCATCGGTCTTCCTGATGCTGAAGATTTTGGTCTATTCTGCCAGA
+AAGTCACTTCTGCCGCGCAGACTCCTAGGGCATCTTCGGAAAGCGCCAGGAAAGAAAAAT
+GTGTTTGTGACCTAACGTCAAAGACGGGATCAGAGTGCGCAGTTCAGGCCCGGCCGGAGG
+GCGACCGGGCGTTGCCAGGGACCCTGAGCTGGGCTCTGACATACGACGAACTTATGTTGA
+GGGACACTTAGGGAAGCACTGATTAATTCCAGCGCCCTTCTGGCTTACAGAGGATTCCAG
+AATCAAGGCGCGGTTTTCAAGGTGGGCTGGTTGCCCATCGAAAAACCGCAACGCGGAGTC
+TGGTATCCTCTGTAAGCCCCTTCGGGCAAGGCCTGAGAAGCGCATTGGACTGCGTTGCGG
+CTCTGGCAAAGGGCTGCGGCCATTCACTGCGAGCCACGCCTTGCCACTGCGCTTCTCAGG
+TCTTGCAGAAGGGTGCTGGAATTAATCAGTGCTTCCTTAGTTGCGGATATAGCGGAAGGG
+GGCTTGCTCGACCTGACTCAACTTCCCCTGCAGGCGCAGGTGATGCAAATGGGCAATGCT
+CTCGCCCATGGCGAAGAGAATGGCATGCTCGTCCAGAGGGCGCCGAAACATCAGCGACAG
+AACGTCCCGGGCTGACTGGGGGTGCTCGCAACGCTCAAGCAATCGATCGATCTGGAGTTC
+ATGGTGTCGCTGAAGCGCTTTGAGCCGTTGGTGCAGACCTTCAAAAACCAAACCATGAGA
+GGGCAGCACGCGGATATTTTCCGGCAATGCGGAGAGACGTTCCAGTGAGGCCAGAAAATC
+GCCCAAGGGATCCTTGTCCTCTTCCCCCGGCCGCATACTGATGTTGGTGGAGGTGTTCCT
+AGGCTGTTTCCTGGTGGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTGAGTATTC
+TATAGTCTC
+>NODE_50_length_1320_cov_1878.61_ID_99
+GGGCGTCGCGCAAGCCGTCGCCCAGCAGGTTGATGGCCAGGATGGTTAGCATGATGGCCA
+GACCGGGCAGGGTGACCGTGGTCTAGGTGTCGTTGTACGTGGGATCCCCGGGTACCGAGC
+TCGAATTCGCCCTATAGTGAGTCGTATTACAATTCACTGGCCGTCGTTTTACAACGTCGT
+GACTGGGAAAACCCTGGCGTTACCCAACTTAATCGCCTTGCAGCACATCCCCCTTTCGCC
+AGCTGGCGTAATAGCGAAGAGGCCCGCACCGATCGCCCTTCCCAACAGTTGCGCAGCTGA
+ATGGCGAATGGCGCCTGATGCGGTATTTTCTCCTTACGCATCTGTGCGGTATTTCACACC
+GCATATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGCCCCGAC
+ACCCGCCAACACCCGCTGACGCGAACCCCTTGCGGCCGCATCGAATATAACTTCGTATAA
+TGTATGCTATACGAAGTTATTAGCGATGAGCTCGGACTTCCATTGTTCATTCCACGGACA
+AAAACAGAGAAAGGAAACGACAGAGGCCAAAAAGCTCGCTTTCAGCACCTGTCGTTTCCT
+TTCTTTTCAGAGGGTATTTTAAATAAAAACATTAAGTTATGACGAAGAAGAACGGAAACG
+CCTTAAACCGGAAAATTTTCATAAATAGCGAAAACCCGCGAGGTCGCCGCCCCGTAACCT
+GTCGGATCACCGGAAAGGACCCGTAAAGTGATAATGATTATCATCTACATATCACAACGT
+GCGTGGAGGCCATCAAACCACGTCAAATAATCAATTATGACGCAGGTATCGTATTAATTG
+ATCTGCATCAACTTAACGTAAAAGCAACTTCAGACAATACAAATCAGCGACACTGAATAC
+GGGGCAACCTCATGTCCGAGCTCGCGAGCTCGTCGACAGCGACACACTTGCATCGGATGC
+AGCCCGGTTAACGTGCCGGCACGGCCTGGGTAACCAGGTATTTTGTCCACATAACCGTGC
+GCAAAATGTTGTGGATAAGCAGGACACAGCAGCAATCCACAGCAGGCATACAACCGCACA
+CCGAGGTTACTCCGTTCTACAGGTTACGACGACATGTCAATACTTGCCCTTGACAGGCAT
+TGATGGAATCGTAGTCTCACGCTGATAGTCTGATCGACAATACAAGTGGGACCGTGGTCC
+CAGACCGATAATCAGACCGACAACACGAGTGGGATCGTGGTCCCAGACTAATAATCAGAC
+CGACGATACGAGTGGGACCGTGGTCCCAGACTAATAATCAGACCGACGATACGAGTGGGA
+>NODE_5_length_30845_cov_61.6996_ID_9
+CTCCCTCCGCCACCTCCGATGAGGGACAAAAGCCCGCCCGCGTCCTGGTCGTCGGCAACG
+AGAAGGGCGGCAGCGGCAAGTCGACCGTCGCCATACACCTGACCGTCGGCTTCCTGCGAG
+CCGGCCTCAAGGTGGCCAGCCTCGACCTCGATGTCCGCCAGGCGTCGCTGACCCGCTACC
+TGGAAAACCGCGCCGCCTTCGCGGCCCGGCGCGGCGTCTCGCTGCCGATGCCGAGCCACC
+GGCGGGGGAACGACCCCACGGCGCCCGACGACGTCGCCGAAATGATCCGCGCCCAGGCCG
+CCGGGCACGATGTGCTGCTGGTCGACACGCCGGGCCGCGTCGACGCGGTATCGATGGCCG
+CCCATGTGGTCGCCGACACCATCGTCACCCCGGTCGGCGAAAGCCACCTCGACCTCGACC
+TGATCGGCAACGTCGACCGCAACCAGGGCCGCGCCATCCGCCCCGGCCCCTATGCCGAGT
+TCGTCTGGGCGGTGCGCCAGGAACGGGCCCGGGCCGGCCGCACGCCGACCGACTGGGTGG
+TCTGCCACAACCGGCGGCGCGCGCCGCAGACCCGCGTCGGCCGCGAGGTCGAGCGCACCC
+TGGCCGACCTGTCCAAGCGCTTCGCCTTCCGCCTGGTGCCCGGGTTCTCCGAACGGACCA
+TCTTCCAGGAACTGTTCCCCGACGGGTTGACCCTGCTGGATCTGCGCGAGTCCGAGACCG
+GCGTCGGCCTGACCCTGTCGCACGTCGCGGCGCGCAACGAGATCCGCCACCTCGTCGACG
+CGCTGGACTTTCGGTGATCGAGCCCCAATCTGGTGGACGGGGCACGCAATAATTCCGGTG
+ACAGTGCACTTGATTCACTCGCGCGGAGCTTGCCGGCAATTCCGGTGACAGGCAATTCCG
+GTGACAGTGCACTTAATTCCGTCCTCACGTCTCGATTGTCTTGGTAAAGTCGACGCTTGG
+GAATTAAGTGCACTGTCACCGGAATTAGGAATTGACGCCGAAATTAAATCAATTAACCGA
+AATCAGTTAATCAGGATTGCCGCCGCATGATCACCATTGACCAGACCCTGACCCCGAAGG
+ACCTGACCGAGGACCTCGCCCGCTTCTGGACGCTGTCCGGGCAGAAGATCCGCCAGCTGG
+CGTCCCGCTGGAACGCGGGCGACGGCGCGCCGGTTTTCACCGTCGAGGGCCGCTACACCA
+GCCGGGGCTGGACCGAATGGACCGAGGGCTTCGTCTACGGCTCGGCGCTGCTGCAGTTCG
+ACGCCACCGGCGAGGACTGGTTCCTCGACTACGGGCGGCGCGGCACCCGCGAGCACATGG
+GCGGGCACGTCACCCATACCGGGGTGCACGACCACGGCTTCAACTGCGTCTCCACCTACG
+GCAACCTGCGCCGCCTGATGGACGAGGGGAAGCTGCCGGAGAACGCCGACGAGCGGGCCT
+TCCTCGACATGGCGCTGGCCTCCAGCGGCGCCGTGCAGGCGGCGCGCTGGACCAACCTGG
+GCCACGGCAAGGGCTACATCCATTCCTTCAACGGCGCCCATTCGCTGTTCGTCGACACCA
+TGCGCTCGCTGCGCTCGCTGGCCGTCGCCCATATGCTCGGCCGCGACCTCAAGGGCGAGC
+ACGACCAGTCGATCTCGCTCATCGAGCGCCTCGCCGCCCATGCCCGCACCACGGCGGAAA
+CCGCCGTCTTCTTCGGCAAGGGCCGGGACGCCTACGACGAATGGGGCCGCACCTGCCACG
+AGGCGATCTTCAACGTCAAGGACGGCCATTTCCGCTGCCCCAACTCGCAGCAGGGCTATT
+CGCCCTTCACCACCTGGACGCGGGGCCAGGCCTGGATCACCCTGGGCTACGCCGAGCAGC
+TCGAGTTCTTCCGCGCGCTGGAGGCCGCCGGTCGTCCCGAGGCCGACGACTGCAGCGACC
+TGATGGGCATCATGCGCGACGGCGCGCGGGCCACCGCCGACCACTACATCGCCAACACGC
+CGACCGACGGCGTCTGCTACTGGGACACCGGCGCCCCCGGCCTGGCCGCCATGCCGGACC
+ACAAGGACCGGCCGGCCGATCCCTTCAACGAGCATGAGCCGGTCGACAGCTCGGCCTCGG
+CGATCATGGCCCAGGGCCTGCTGCGACTGGCCGCCGTGCTGGCCGAGGAAGGCGACGACA
+GCGCCGAGCGCTACCGCCAGGCCGGCCTCACCGTCGCCCGCGCCCTGCTGAAGGCCCCCT
+ATCTGAGCGAGGCCGACGGCCATGAGGGGCTGCTGCTGCACACCATCTACCACCGGCCCA
+ACGGCTGGGACCACATCCCGGCCGGCCGCAAGGTGCCCTGCGGCGAGAGCTGCCAGTGGG
+GCGACTACCACGTCCGCGAACTGGCCCTGATGATCGGCCGCGAGGCGGCGGGCCAGGAGC
+CTTATCGGTTCTTCAACGGGCTGGTGTGATCGGGGTTCTCTGATTTAACGGACGACGCCC
+GTCCTAATTCCGGTGACAGTGCACTTAATTCCTTGTTCCGCATGGCGGCCATCTTGGAGA
+GATTGGCGCATGGGAATTAAGTGCACTGTCACCGGAATTGACCGTCCGCGGAATCACCGC
+TCGTGGAAGGCGCGGATCGACAGCTTGTGGAAGGGCTTCATCAGGTATTGGAGGACGGTC
+CGCCGGCCGGTCTTGACGTCGACGCTGACCGTCATGCCGGGGATGATCGGCAGCGGCTTG
+CCGGTCTTGTCGAGCAGGCTGTTGGTCTTGGTCCGCAGGCGGATCATGTAGAAGCGCTCC
+TTCTTCGCCTCGTCGAAGATGGTGTCGGCGCTGATCTGGTCGAGCGTCGCCTTCAAGGAG
+CCGTAGATGGTGTAGTCGTAGGCGGTGAATCGCACCGTCGCCTCCAGCCCCGGATGCATG
+AAGGCGATGTCGGAGGGGCGGATCTTGGCCTCGACCAGCAGGTTCTCCTCGGCCGGCACG
+ATCTCCATCAGGTCCATGCCGGGGCGCACCACGCCGCCGATGGTGGTGAGGAAGATCTGC
+TTGACGACGCCGGTCACCGGCGCGCGGATCACCGTGCGGCGCAGCCGGTCGTCGCGCGAC
+GTCACCACCTGGCCGAGGGCGGCCATGTTGACCTGGGCCTCGTTCAGTTCCTTCAGGGCG
+CGGCTGCGGAACTGCGCCTTGGCCTCGGTGATCGCCTCCTTGGTCTCGTCGATGGCCGCC
+GCCAGCTTGAGAAGCTGCTGCCGGGCGACCGCCAGATCACCCGCGTCCTGGCTCTCCTCG
+CGCTTGAGCCGGATCAGCTCGATCGGCGCGTTGATGCCCTTCTTCACCAGCGGCTCGAGG
+ATGGCCATCTCCTCCTTGGCCAGCTTGATGACGGTCCGCAGGTGCTCGATCTTGGCCTTG
+GTCTCGTCGACCTCGTGGAGCTTCTGCTGGTACTGGGCCTGGAGCTTGGCCAGCGAGGCA
+TCCTCCTCGCTGCGCCGCGCCTCGAACAGGGACCGCTCGGCCTGGGCCACGGCGGGGAGC
+TGCTTCTCGACCTCGGCCGGGAATTTCAGCGCCGTTCCCTCCAGTTCGGCCTGCAGGCGC
+GTGACCGCCGCCTTGAGGCCGAGGAACTTCAGGCGGTTCTCCATGAAATCCGAGGAAAAC
+TGCGTGTCGTCCAGCTGCATCAGCACCTGGCCCTGCTTCACATGGTCGCCCTCGGCGACG
+TAAAGCTCGGAGAGGATGCCCCCTTCCAGGTTCTGGACCACCTGGACATGGCCCGAGGGG
+ATGACCCGCCCCTCGCCGGTGCTGACCTGGTCGATCTTGGCCCAGGACGCCCAGAGGATG
+GCCAGGATGAAGAACACCAGCACCGCGATGAGGATGATGTTGGCCAGGATCGTCGGCCGC
+CGGCTGACCGCGGCGCGAAGTTCGGACATGTATTCGATGTCTGGCGATGCCATGGTTCTC
+TACTTGCCCGTCTTGACCTGGCCCTTGGCCAGGCCGCCGAGAATCGTCGCCTTCGGTCCG
+TCGGCGACGATGCGTCCGGCATCCATCACGATCAGGCGATCCACCAGGCTGAGGACCGAC
+GTCCGGTGCGTCACCAGGATGATCGTCCGCCCGCCCGTCGTCCGGGCCAGGGTGTCGACC
+ACCTTCTTCTCGGTGCCGGTGTCCATCGAATTGGTCGGCTCGTCCAGCACCAGAATGGTC
+GGGGTCTTGAGCAGGGTGCGCGCCAGGGCCACCGCCTGGCGCTGGCCGCCCGACAGGCCG
+CCGCCCCGCTCGCCGACCTCGAGGTCGTAGCCCAGCGGGTGCTGGGTGATGAAATCATGC
+AGACCCAGCGCCTGGGAGACCTCGGTGATCTCGTCGTCGGTGGCGCGCGGCACGCTGATG
+GCGATGTTCTCCTTGATCGATCCCTTGAACAGGAACACGTCCTGGGGCACGAAGCCGACG
+TTGGCCCGCGCGTCGCTGGGCTCGATGTGGCGCAGGTCCGTATCGTCCAGCAGGACCGTT
+CCCGAGGTCGGCGCGTAGAGCCCGGCCAGCAGCTTGGCGATGGTGCTCTTGCCCGATCCC
+ACCCGGCCGACGATGCCGACCCGTTCGCCGGGCTCGATGACGAAGGAAATGTCCCTCAGC
+ACGTCATGATCGGTCCCCGGATAGCGGAAGGTCACTTCCTGGAACTCGATCTGGCCGCGC
+AGGCGGGGACGGTGCAGGAAGTTGGCCTCGGGCGGCCGCTCGACCGGGCCGCGCATCACC
+GCGTCGAGCGACTTGAGCGAGGTCCAGGTCTGGTGGAAACGCATCATCAGCTGCGAAACC
+TGGGCCATCGGCCCCAGGGCCCGTCCGCAGAGGATGACCGAGGCGACCAGCCCGCCCGAG
+GTCACGGTGCCGTCCTTGACCAGGAAAATGCCGGTCACCACCATGGCGATGATGGTGCCC
+TGCTGGACGAACTGGACAAAATTGACGCCCAGGTTGTTGAACAGCCGCATGCGCTGGCCG
+ACGGCGGCGCTCTGGCCGACGACGGTCTCCCACTTGGCCCGCATCCGCCCCTCGGCGCCG
+ACCATCTTGATGGTCTCGTATCCGAACAGGCTCTCCACCAGGACGCCGTGCTTGTGCTCG
+CCATGCACCATCAGCTTCTTGACGCTCTTGGCGATGGGGAACTGCACGAACATGCCCCAG
+AACAGCACCAGGGCCATGGCGCTCCCGAGCACCATGCCGATCTCGGGGCTGAGCATGAGG
+ATCACGGCGAGGAAGAACAGCGAGAACGGCAGGTCGATGAAGGCCGCCAGGGTCGCCGAG
+GTGAAGAAGTCGCGGACCGTCTCGAACTCGCGCAGCATGCTGGCGAAGGCGCCGGACGAT
+TGCGGCCGGTGCGACGCCTTGAGGTCGAGGACCTGGTCGAAGATGCGACAGGCCAGCACC
+ACGTCGGCCCGCCGGCCGACGAAATCGATGAACCAGCCGCGCAGGTTCCGAAGGATGAAA
+TCGAACAGCAGCGCCGTCGCCGCGCCGATGGCGAGCGCGATGCCGGATTCGACGGCATTG
+TTGGGCAGCACCCGGTCATAGACGTTCATGGTGAACAGCGGATTGGCGACGGCGAAGATG
+TTGATCACCACCGAGGCCATGCCGACCTGGGCATAGGTCCAGCCGTTTTTCGCCAGGGTG
+CCCCAGAACCAGGAGCGCGGCTTGGCCAGGTCGGCCCCGGTTCGCTCGCCGCCCAGGTCG
+ACCTCGGGCTTCACCAGGATGGCGAAACCGGTATAGGCCCTCTCGAGCTCCTCGGGCGAC
+AACTCGGTGGTGCCGTGACCGGCATCACCGGCAGTCACCAGGAAATGGCCGGTATCCGAC
+TTGCCGGTCAGGACCACGGCGCCGCGGTTGCGCAGCAGAAGGACGGCCGGCAGGGTCCAG
+GCATGGATGCGGCCGAGCCCGCGCCGCACCACCTGCACCGACAGCCCGGCCCGCGCCGCC
+GCCCGCTTGAACAGGTCCACCGGAATCGGCCCGTCGGGCTTGGGCAGGGCGGACAGCAGC
+ACCGATGGCGACTTGGGCTGCCCGTGGTAGGCGACCAGGAACAGCAGGCAGGACAGCAGG
+GAGTCGTCGTCCTCGGCCCCCGGAAGGGCGTCCTCCAGCGGCCCGGCCGGCCGATCGTCG
+TTCCCCGGGGCCTCGCCCGCGGGGGTGTCGACGCCGAGCGGGCGCGCCGGAGCCTCGTCC
+GTTTGCGGATCGTGGACGACCTTGATGTTCGAGGCGTTGTCGGCGGTCATCTCCCTACCC
+GTCGCAACCCAGACCCCGCGCGGCGGGGACGCGGATCCCCCGCCTTGCCAACGCCAAGCC
+TGCCGTTCGGCGAGACGCTGGGCGCCATGAATGATAGGGGATTCCAGCCGCCCTTGGCTA
+GGGAGCCTTGGGCGCCTTGCCGGTCGCGACCTTGACGCCCATGTCCTTCAGCAAGGTGCC
+CCTGACGGCCAGGAAGTCGTAAGCCGCGGAGATCTGCCGGTATTCCGCCGTCGTCAGATC
+GCTCCGCGCGAGGAACAGCTCGTTGCCGGAGTCGAGGAGCTCGATCAGCGTCCGCTGCCC
+CAACCGGAACTGCTCGCGATAGGCGGCCGTCACCTCCTTGGCCGTGGCCGCCCGCTCGCG
+CAGCAGCGCCACCTGGTCTCGGGCCACCTCGTAGTCGGTAAGGGCGACTTCCAGCTCGCG
+GCGGATCTTGCGCTCCACCTCGTGGATCCGGTACATGGCGGCGCTGGACTGCTCGAGCGC
+CCGGCGCACCTTGGCCTGGTCGGCGCCACCGCCGTAGAGGTTCCACGACAGGGTGAGCAG
+GGCCGTCGAATCGGTTTCGAAACCGCTGACTCCATCCACGCCGTCGCGCTGCTCATGCGC
+CACTTCGACGTCGACCTGGGGGAAATAGCCGCTGCGCTCGGCATTGGCCGTCAGCGTCCT
+TGCCCGCTCGGTCTCGACCGCCGCCTGGAACGAGGGATTGTTCTTCAGCGCCTCGTCACG
+CGCCTCATCGACCGAGGCCGGGATTGCCACCGTCGGCATCGGGTAGTCCTCGAGGGTTTC
+GGGCGTTTCGCCGATCGCCTCCTGGAAATCGCTGATCGAGTTGCGCAGGTTGCCCTCGGC
+CCGGCGGCGCTGCGACTGGGCGTTGTACAGGCGCGTCTTGACCTGGGTCACCCGCGTCTC
+GGAGCCGCCGCCGGAACGGGCCGCCTCCTCGACGTCGGCCAGGATGCGCCGGTGAAGGTC
+GATATTGTCGACCGCATACTGGACCAGCTTGCGATCCCGGGCCACGTCCAGATAGGCGCG
+AATGGCGCGCTGGGCGATCTTGGTCGCCGCCGACAGGACATCGAAATGCGCCGACTGGGC
+ACTCGCCTTCGCCGATTCCGCCCGATTGGCCGTTCCTTCGCCGTCATACAGCATCTGGGT
+CATCGCCAGCCGCTGCTTGTTCCGCCACTGGTTCTCCTTGATCGACGACTCGTTGACCCG
+GCGGGCGTGCTGATAACCGGAATCCGCCGTCAAATCGAGCGACGGATAGAAACCGGCCTC
+GACCTGATCGACGCTGCGCTCGGCGGCCCGATACTCGGCCTCCGTCGAGGCCACCATCGG
+ATGGGACTGGACGGCCATCTCGACCGCCTCGCGGAGTTGCTGCGCCTGGGCATCGGCCAT
+GAAGGGGCCACCGAAGACCACGAGGCCGCTCAGCAGGAGGGACCCCCAGGAGAGAGAGTG
+GCCGAGCCGGCCACTGGGCGTCGCATTACGGTGGCCGTTTCGTCGATTCGCCGCGACCCC
+GGCGTCAGAGAATGACTTCACGATGTTCCCCCACTCGTTTCTGTTCCGAGAGATCGGCGA
+TATGACAACCGCATACTTCAAGGCGTTCCGCCCTTCGTCTGTCGCCACTCCCAGGCACCC
+GAGGCCGCCCGATTCCCCTCCTAAATCAAGCCCCTCGACTACCGATAATGGAACCAAGCC
+ACGATAATACGGATAATTGGCGAATCAAAGCACAACCTTTCGTCCCGCCTCACCGCCGTC
+CGCCCTTCGGAAACGCCCGGTTTCCCGGTTGCATCGCCCCTCGCCGCCATGCGGCAACAC
+ATGCCAAATTGGCAGAAATGCCAGTCATCCTCCGGCTGCCGCTCGCGGACTTGACCGATG
+TCCGAATCACCCTCGCCCTCGCTTGCCTGTCAGCACACCCTCATAACGCAGGATTTTCAA
+CGAACACCGAAACAATCTTGAATTGATCGACCAGCGATTCCGCCAACCCACGATGCCTCG
+CGGCCAATGGAAAGCAAGGGGCAGAAATGCCACTTGGCACCTATATTTCACTTTTGGCAT
+TTCACAAGCTGGTCAGCCAACACCTTTCCGGGTATTGATCATTCATTGCTGCAACGGATA
+AAATACAGACACTGGATTGATCGCCCCCTTAAACAGGGCCGATCGTGGTCGGGGGACCTC
+AACCATAAGAAATATTTATTCAATGCCTAATAGCTGGAAGGTTGATACATCACCTCCCAT
+ATCGATTTGTTGATGCATAGGGCGCACCCGGGGAGGGCGTGCCATTCGAGGTAGCGCCGG
+TTTGGAGGGGCTTGGCGCAGAGGGGGAGAAAGCCGTGGCTACGCTTGAACTGATCGTCGA
+GCGCGCGTCGGGGGACGTGCTCAAGGTTGAACTGAAGCCCGGAACGAACGTTCCCGCCAT
+CCATCCGGGCGACAAAGTCCAAATCGTCACCCCGGCAGGCGAAACCCTGAATGCGGTGGT
+CGTCGGCCAGGACGTGCAGATCACGCCTGTCGACGCCTCGGGCACGGTCGGCGAAACCAT
+CGTCTTCAAGAACCTGGCTCTCTACCTGCATGACGGGCAGAGCGAGGTTGCCGTCGTCAA
+CGCGGATACCGGCCAGACCACCGAGATTACCGATGTCGCCTCCCTGGCCGATCTCGGCAC
+CGTCCCGTTGCAGATGGCCTCGGGCGAGGGAACCGGGCCGGTTTCCCCCGGCACCTCCTC
+CCCCTTCCAGAATTCTGACGCCATCGACCACGGAGGCGAAACCGCCGGCAACGCGGCCGG
+AACGCTGGGCGACATCCTGAACCGCGGCGCCGCCGGCACCGATGGCGGACGCGCTCAACT
+GGCCGGCACCGGCGAGACGGGGGCGGGGACAGGAACGGGCAGCAGCACCACCGACCATGT
+CGAGACTCCGATCTCCGAGTCGACGGAGGGCGGCGGCAGCGGTACCGGAACCGGCACCGG
+CACGACCACCTCCGGCCATGCGGTCGACGGCTACATCGTCGGCGCGACGGTCTTCGCCGA
+CGCCAATGCCAACGGCGTGCTCGACTCCGGCGAGGCGTCGACGACCACCTCGTACAACGG
+TACATTCGAACTGAGTGGCAGCAGCGGCCAGTTGGTCATGACCGGCGGCGTCGATCAGGC
+CACCGGCGAATCCTTCAAGGGCACGCTGACGGCGCCCGCCGGCTCGACGGTGGTGACCCC
+CCTCACCACCCTGATCCAGTCGTTGGTGGAGGCCGGGCAAAGCGCGGCCGACGCCCAGGC
+GGCGGTGAAAAGCGCCCTCGGCCTGACGGGAAACAGCATCGACCTGACCACCGCCAACCC
+GGTGGAGGACGTGGAAAACGGCGTCAGTGGCGCCGACGACGTGCTGGCGGCGGCGATCAA
+GATCCAGAACACGGTGGTCCAGGCGGCCTCCGTCCTTCAGGGCGCCGGCGGCTCCACCGT
+CGCCATGAGCACGGCGACCAACGCGGTGTTCGCCCAACTGGCGACGACGCTTCAGAACAA
+TCCGGGCAGCAATCCGATCACCGACGCGACCGCCGTCCAGAACCTGATTACCGGCGCCGC
+GAACTCCAGTTCGCTGGGTCTGAGCAGCACCGCCAAGACGCAGGTCGGTAACGCCGCCTC
+GGACGCCGCGTCCGTCATCGATGCCGGCAACAGCCATATCAACGGCCTGTCCTCGACCGG
+CAGCAGCCTGCTGACCGATCTGGCCTCGGCGGCCCGGGTGGCGCAGAACGGCGCCGCGGA
+GGCGCTCCATGACGCCTTGAACGCGGTCCAGGGGACCAGCAACAGTGCCAATCTGAGCAC
+CGCCACCAGCTCCTATACCGGCGCCAACCTGACCTCGGAGATCGGCAACGCGTCCTCGGG
+CCTGGGAACCGTCGGAACGGCCAGTTCGGTCGGCACATCGGGCGACGACACCATCCAGGG
+AACCAGCGGCAACGACACCCTGAACGGCGGCGCCGGCAACGACACGATCAGCGGCGGCAC
+CGGCAACGACATCCTGATCGGCGGAGCCGGCAACGACACGCTGAAGGGCGAGGCCGGCAA
+CGACACCCTGGATGGCGGCGCCGGCGACGACTCCCTGTATGGCGGCGCGGGAACAGACAA
+GGCCCTGTTCGACGGCAATTTCAGCGGCTATCAGATCGCCACGGACTCCGGATCGTCCGG
+CGTCATCACGGTCACCGGCAGCGGCACGGACACCATCGACACGACCGAGGTGCTGAAGTT
+CAAGGACCTGACGGTCCGCATGGTCGGCGACAGCGGTGGCACGGCCAACGGCTACACCTC
+CCTTTCCAGCGCGTTGAGCGCGGCGAGCGTCGGCGAGAGGATCCTGATCCTCGATTCCGC
+CACCGATCCCTCCACCCTTACCCTGTCCAAGAAGGTGAGCGTGCAGAAGATCGGCGAAGA
+CCCGCTGATCTCCATCGCCTCCGACGGCGCCCTGGTGGTGGACGGCAGCCAGCTTTCCGC
+CGTCACCACGCTCGACCTTTCAAGCCTGCCCGGCACCACGACGGTGCGCTTCACCAGCCT
+GGGCAGCATCGCCAGCATCAGCACCGCCTCCACCGAAACCCTGAACCTGTCGGCCAGCCA
+ACTGGACGGACTGACGGTCTCGGGAAGCGGCAAGATCCAGACTTCCGGCATCGTCGCCAC
+CAGCGCCGACCTCAGCAACCTGTCGTCCGACCTTTCGGTCGCCTCGGGACAGTCCCTGGA
+GCTGACCGCGGCCCAGGCCAGCGGCAAGACCATCGCCGGCGCCGGCAACGTGACCGTCAA
+CGCGCTCGGATCTTCGGCCGTCGACCTGTCGGGAATCACCGCGAGCGGCACGCTGACGGC
+CAACGTCCCGTCCTCGGCGACACTGAACACCAATACCGATCTCGGCACATTCGGCGTCTC
+GGTCGCCAGCGGCCAGACTCTGACTCTGTCCGCCACCCTGGCCGACGGCACCACCATCGG
+CGGCGACGGCAACGTGACCGTCACCGGGCTGGCGGCCGCCACCGACCTGTCCAGCGTTTC
+GGCGTCGGGCACGGTCACGGCCACCGTGACGTCCACCGTCGACATCAGCAGCAATACCCA
+TCTGGGCAGCGTCGACGCCTATCAGGTGACGGGCGCCCTGACCCTGACCGCTGCGCAGGT
+CGGCGACAGCACGATTTCGGGCAGCGGCAACGTGACCGTATCCGGGTTGGCGGCGACGAC
+CGATCTGTCGGGCATCGCCTCGTCCCTTTCCCTGACGGCGTCGGTAACGAGCTCCATCGA
+CATCAGCGCCAACACCAACCTGACCACGGTGGACACCTATCAGGTCTCCTCGGGCCAGAC
+TCTGACTCTGTCCGCCGCCCAGGCCGCCGGTCATGCGATTAGCGGCGGAACGGTGACGAT
+CAGCGGCAACATCACCGCCAATACCGACCTGACGGACATCTCCTCGACCCTCAGCTTCGA
+TGACGGCGACAGCGGGGCGATCTCCGTCGCCTCCGGTACGAAGCTGACCGTGACCCCGAG
+CCAGGCCGCGGCCCTGCAGACCGCAGGGCAAACCATCACCGGCGACGGAACGGTGCTGAT
+CGACGGCAACGTCACGGCCGACACCAACCTGACGAACATCAGCGCGGCGGTGGACTTCAA
+CGGCAACAGCGTCTCCGTCGACAGCGGCCATACCCTGACCCTGACCGCGACCCAGGCCAG
+CGATACGACGATCTCCGGCGCCGGCGCCGTCGCCCTTTCGGGCAGCGACACCAACGCCGA
+CCTCAGCAGCATCACGGCCGACATCACGGTCGCCAGCGGCCAGACCCTGAGCCTGAGCAC
+CGCCCAGTTGGCCACCCTCGACAGCAACGCAATCCCGATCGGCGGCGACGGCACGGTGTC
+CCTGACCGGCAATGCGACATCGGCTCTGAACAGCGACCTGAGCACCTATCTGGGCAGCAG
+CCTCAACCTGGCGGTGCCCTCCGGCGAAAGCCTGAGCCTGACCGCGATCCAGGCCAACGG
+CCTGACCATGGAGGTTGCCGGCACGGCGAACATCACCGGGCCCGCCGGCACAACGGCCGC
+CGATTTCTCGAACATCTCCTTCACCGGCAGCGGGGCCGCCACCTTCACGGTCGGCGCGGA
+CCTCGTGATCAGCGAAGCCAACGCCGACTTCGGCAGTGTCTCGATCAACATCCCGGCCGG
+CCGGACGCTGACCATCGACGCGGCCGACGCCAGCGGCGTGACGATCAGCGGCGACGGCAC
+GCTGGCCGTCACCGGCACCCTCGACAGCAGCGTCAATATGTCGAATTGGGGGACGGGCGC
+CATTGACCTGACGAACGTCTCCGCCAGCAACTTCAGCCTGACTCAGCTGGACCTCAACGG
+CTCGGCGGACTACCACCTCACCTACGCCCAGGTCCAAGCCCTCAGCGACGGCATCGACGG
+CAACAATAGCGACAACACCCTCATCATCGACGTCAGCACGGCCGGCGGCGTTACCTACAC
+CAACAACGCCGCGACGATCGATCTGGACATCAGCCTCCTGGGCGGCGCCGACCGCGTGAA
+GTTCGACTTCGGCGGCACGACCGATAGCGGCAACACGCTCACGATCAGGGGGCCCCTCGG
+CTTCGGCGACGGCTCCGACACCCTGGAATCCCGCCATGGCACCATTTCGCTCACCGATCC
+CGGCCTCACCTTGTCCGGTGGGCCGGAAGCCCTTGTTGCCAATTCGGGATTCTCACTGAC
+GGCGACCCTCTTCGATCTGCTCTACGGCAGCAGCGGCGTCACGCTCCAGGGCGAAGGCAC
+CTACATCGTCTCGATCGATGCGGGATTTGCTTCGGGCGCATCGCCAACTCTCGATCTGAC
+CGTGCTCGACAACTTCGTGCCGGCCGGCGGGGTCCTGCCGACCCTGCAGATCGTTGCGAC
+GGGGTATTCGGTGGTCGGTGGTGACGACGGAACAGGGGACGGGATCGCCACCCTGAGCGA
+CGGAACCCACACCATAACCATCAAGCTGCCGGACGACCCGGACAACGCCGGGACCTTCAA
+TCCAGGCAATACGCCGGTCATTATCGAAATCGATAATGGCACGAGCCAGTTCTTTCTCGG
+CGGCCTCGACGATCAGCGCGCCTATTACGAATCGGAGACCACCGTCTACACCGGCTCACA
+GTTCGCCGACCTGGCCACCGCGATCGCCACCGACGCAAGCAGCCTCGGCATCAATGCGGG
+TGACATCCAGACCATCAAGCTCGGTGATTCCGTCATTCTCGACAGCGATTCCGCGGTCGA
+CCTTTCCGCATTCGGCGGTGTCATCGACTACAACGGCCAAACCATCCAGGTCACCAGCGG
+CGACAGCCTGACCCTGACCGCGGCGGCGGCCGATGGGGGCACCATCAGCGGTGCCGGCTC
+CGTCACGATCACCGACCTCGGTACGACAGCCGTCGATTTCTCCGGCCTGACGGCGGCATC
+CGTTACCCTTGCGATCAGTTCCGGAACGGTGGACCTCAGCGCGATCAGCGGCCTCGATTT
+GGGCAACGTGGGCATCACGGTCACCACCCCCGGTGCCGTGACCCTGACGGCGGCCCAGGC
+GGACGGCCTGTCCATCTCGGGCAACGGCGATGTCACCCTCACCGGTCTGGGCGCCAGCGA
+GGTCGACCTTTCCGGCCTTACGGCGACCAACGCCACCGCCGAAATCTCGGCCGACCTCAC
+GCTCAGCAGCCTCACCAACCTCGGCAGTCTCGACCTGACCCTCGACGACGGCGTCACCTT
+GACGCTGAGCCGGGCGCAACTCGACGGACGCGACATCTCGCTCGCCAGCGGGTCGGCGAC
+CCTGGCCTTCGGCGGCAATGCCTCGGGGCTCGACCTCAGCCAGATCGCCTCCGGCATCGC
+CTTCGAGGTCGTCGCCGGGCGCACCCTGACGCTGTCGACAGCACAGATCAATGACGGCCA
+TACGATCACCGGCGCCGGCAGTCTCGTCGTCGTGCTCAGCGGCACGGAAGTCGACCTGGC
+CAGCACGGCGATCCAGGTGACGGGGACCAGGACCGCCGTCGTGTCGACGTCGGCCACCCT
+GGACGGCAATACCGACCTCGGCGACTTCTCCGTCTCCATCCTCAGCGGCCAGACCCTGAC
+GCTGAGCACCGCCCAGGCGGCCGAGCATGCGATCAGCGGCGCCGGCAACGTCACCGTCAC
+CGGGATCGGCAGCACGGCGGTGGATCTGTCGACCATCACCGTCACCGGGACCAAGACGGT
+CAGCCTGTCGGCCGACGCGACACTGGATCCCGATACCAACCTCGGCAACTTCGCCATCGA
+TACGGCGGGCCACAGCCTGCAATTGACGGTGGCGCAGGCCAACGGCCTGTCGATCACCGG
+CAGCGGCACGGCCGTCGTCACCGGCCTCGGCAGCGACACCGTCGACCTGTCGGGAATCAC
+CGCGACGGCCAGCACGACGGTCTCCGACACCGTCGCCCTGGCGGCCGGCACCAATCTCGG
+CAGCGTCGCCGTGACGGTGGACGGCACCGGAAGTCTGACTCTGTCCGCCTCCCAGGCCGA
+CGGCCACACCATATCCGGCACCGGCGCGGTCACCGTGACCGGACTGACGGCCGGCATCGA
+CCTGTCCAGCCTCGCGTCCTCGCTCGACGTGACGGCGACGGTCCCCGGCACCGTCGATAT
+CACCGGCAATACCGCCCAGTTGGCCACGGTCGACACCTACGAGGTTGCGGGCGCCCTGAC
+GCTGTCGGCCTCGCAGGCCAGCGGCCATACCATCGAGGGCTCCGGCAGTATTGTCGTCAG
+CGGTCTCGACGGTTCCGCCGCCTATGACCTGTCGGGCATCACGGCGAGCGCCAGCACGAC
+GGTCTCCGGCACCGTCACGCTCGATTCCGGCAGCAACCTGGGGACCGTCGCGGTCAGCGT
+GACGGGCAGCCTGACCCTGGCCGCCGCCCAGGCGACCGGCCATACCCTCAGCGGGGATGG
+CAGCGTCACCGTGACCGGCCTGGCGGCGACGACCAACCTGTCGGGCCTCGCCTCGACACT
+TTCCTTGACGGCGGCGGTCACGGGAACCGTCGATATCAGCAGCAATACCCTTCTCGGCAC
+CGTCGACAGCTATACGGTGAGCCAGTCGACCGACGCCCTGAGCCTGACGGCGGCGCAGGC
+CAGCGGCCATGCCATCTCGGGCAGCGGCACCGTTGCCATCAGCGGTCTCGGGGCTGCTGT
+CGTCGATCTGTCGGGCATCGCGGCAACCGTTGATGCCACGGCGACGCTCTCCGGCACCGA
+GGTCATCCTGACGGCGGGCACCGATCTCGGCACGGTGGCCCTCAGCGTCGGCAGCGGCCA
+GACCCTGACCCTGGGAGCCGCGCAGGCCAGCGGCCATGCCATCAGCGGCGGCGGCGACGT
+CGTCGTCAACGGACTGAGCGCGAGCACCGACCTGTCGACGGTGACGGTGACGGGAACCGT
+CACCGCAACGGTTTCCGCCGACCTCGACATCAGCGCCAGCAGCCAGTTGGGCTCGGTCGA
+CACCTTCCAGGTGGTCGCCGGCAAGACCCTGACCCTGACGGCAACCCAGGCCAACGGCCA
+GGCCGTCGAGGGCGGGGGCAACGTCACGGTCACCGGCCTGGCCGCCGCCACCGACCTGTC
+CGGCATCACCGCGACCGGAACGCTCACCGCCACGGTGACGGCCGACACCGACATCACCGC
+CAATACCCATCTCGGCGCGGTCGATAGCTTCCAGGTCGCCAGCAGCACGACCTTGACCCT
+GACGGCCGATCAGGCCGATGGCCAGGCCGTCACCGGAACCGGTAACGTCACCATCACCGG
+GCTGGGCACCACGGCGGTCGACCTCAGTGCGATCGCCGCCACCGGAACGCTGAGCGCGGC
+GATCAGTGGCGATATCACGCTGGCCGGTGACACCAACCTCGGCGACGTCACCCTGACGGT
+GGGGGCAGGCAACACGCTGACCCTGACCGCCGCCCAGGCCGACGGAAACACCATCACCGG
+CACCGGCGCCGTGGTCATCACCGGCGACGTGGCGGGATACGACCTGACCCACATCGCCGG
+GACGCTCGACCTCACCCTGCCGGTGACCGGCGACGTGCTGACCCTGACCGACGGCGAGAC
+GGTCCACCTGACGGTCGCCGAGGCCAACGCCTACGACTCGATTACCGGTGACGGCACGAT
+CCAGCTGAGCGGCAACGCGACCGCGAACTTCGACCATCTGACAAGCATCCTCGGCGATGG
+CGTCAGCCTGGCGGTGGCGGACGGCGACACGCTGTACCTGACGGCAACGCAGGCCTCCGG
+CGTGACTATCGGCGGCATCGGCACGGTGGATGCCAGCGGCACCGTGACGGACGGCGATTT
+CTCGGGCATTTCGGCCGACCTGAACCTGACCGACGCGACCCTGGACGGCACCACGACCCT
+GCCCACGGTGGGTGCCGGGCACACCCTGAGCATGACGTCGGACCAGATCAACGCGGCGAG
+CATCGCCCTCGCCGATTCGACGGCAACGCTGCATGTGGCGGTCTCGTTCGATGCCCTGAG
+CTCGAGCAACGACGCCCTGCCGGAGATCGACATCTCCGAGATCCGGGTCGACGGGAGCAA
+CAGCCCCGAGGCCGTCTGGAATTCCGTCGACGTCGCCTCCGGATCGATCGTCGACAAATT
+CAAGCTGTTCTGGATCAGCGCCGACAAGCAGTACTACGACTCGACGCCGCTCGGCCAGGA
+CGTCGATGCCAACCGGGCGTTCGTCGAACTGGGCAATCTCTACGCCGCCTACCTGGCCGG
+CGCGGACGGCGAACTCGGCACCGCCGACGACGGCACGCCGATTCTCGATGTGGTGCAGAC
+CAAGTCCGGCGGCGTCGCCGATTACGACGCCCGCCAGCAGTCCCTGCACGACAACCTGCT
+GGGCAATCTGAGCGATGGTGCGATCGCCGGCCGGTTCGGCACCGACGATCCACGCAGCGA
+TCTGGCCAAGCTGTTCGGCGACCGCCCCTACCTGGCGGGTTCCGTCGACGGCAACGGCCT
+CTACACGAACGACGATTCGGTTGCCGCCGTGGTCGGCTGGGACCTGTACCACGGCCTCGA
+CTATACGGCCAGCTTGAGCGGCGGCTACGCGGTGCTCGACGGCGACAACAGCGTGACCGG
+CACCAGCGGGAGTGACTACATCTACGCCGGTGGCGGCGATGATACCGTCAGCGGCGGCGA
+CGGGGCCGACGTCCTCTATGGCGGTTCCGGCGACGATACGTTGAACGGCGGCGCCGGCGA
+CGACACCCTTTACGGTGGTTCCGGCGACGACACCCTGACCGGTGGCGCCGGGGCCGATAC
+GCTGAGCGGCGGCGACGGAACCGATACGGCCAGCTATGCCGCTTCGACCGAGGGCGTGAC
+CGTCGACCTGGAGACCGGCGTCGGGACCGGCGGCGACGCCGAGGGCGACACCCTGAGCGG
+CATCGAGAACGTCACCGGCTCGGCCGAGGCCGACGCCCTGAGCGGCGACGCCAACGCCAA
+CGTGCTCGACGGCGGGGCCGGCGACGACACCCTGACCGGCGGCGCGGGCGACGACACCCT
+GAGCGGCGGCGACGGCACCGACACGGCCGTCTACACCGCGGCGCTGACCACAGACAACAT
+CACCTTCGACACCGACCATTGGGTGGTGGCGACCGATGGCGCCGAGGGGACGGACCAGCT
+GAGCGGCATCGAGGTCATCGACCACGGCGGCAGCGGGAACATCCTGCTGGTCGGCGGCGA
+CGGCTTTGCGAGCATCCAGGACGCCATCGACGTGGCGAGCGACGGCGACACCATCATGGT
+CGCCCCGGGGACCTACGCGGAATCGCTGACGATCGACAAGTCCCTGACCCTGATCGGCGA
+TCCGGCGACCGGCGATGCCGGGGCCGGTACGTCCGCCCCTCAAATACTCGGCAGCACGGA
+CTGGACCCTGGCCACGGTTTCCATCGAGGCGGAGAACGTCACCTTCAGCGGCTTCGACGT
+CACCAACGACACCGGCCCCTATGGCATCCACATCAAGGCCGGCGACGCCGACGTGTCCGA
+CAACTATGTCCACGACATCAACGGCGCGCTCAGCGGCGACGGCATCCGGGCGATCTTCAT
+CAACCCGGTCGACAACGTCACCGTTTCAAACAACATCGTCGAGGACTTCGGCAACGCCGA
+CAACCCGTCGGCGGCCAGCTACACCAAGACCGCCGCCGGCATCTACTACTGGGCGCGTGG
+CGGCACCCTGCCCGGCGGCACGGCCGACATCGCCGAACTGCACAACGTCACCATCGAGAA
+CAACGTCATCCACAACGACGGCCTGCCGACGTTCACCGGCACGTCGGTCCTTGGCATCTG
+GGTCGGAAGTTCGCAGGGTGGCTCGGTATTGGACACCGTGAGCATCGCCGGCAACCAGAT
+CAGCGATCTGCACACCGACAACGCGGACAGGTTGACCGGCGGGATCCTCGTCAACCACGG
+CTCCAACCCCGACGGGGTCGACCCCCTCGCCAGCCTCGACACCCCAGGGGTGACGACCGG
+GCTGGAGATTTCAGGCAACACCATCGACGACGTGTCGGGCGCCTCGGTGTTCGCCGTCGG
+GCTCCGGGGCCAGACGCCGGATGCTTCCGTCATCGACAACGTCATCAGCAATCTGGCGCT
+GGCGTCGGGTTCCTCCGACGGGCTGCTCGCCTCCATCTCGTTCCAGTACAACACGACCAC
+GCACAGCGTTTCCCTGAGCGGCAACGATCTCGGCGGCTATGACCTGCTCCAGGTGGGCCA
+CGACACGTCCGACGACACCCTGACCCCCGCCACGGCCGACGACACCCTCACCGCCATCGA
+CGGCTACGACAACATCCTCGTCGGCCAGAGCGGCGACGACACCCTGACCGGCGGCGACGG
+CAACGACACCCTGCTCGGCGGCAACGGCACCGACACCCTGACCGGCGGCGGCGGGACCGA
+CACGCTGGACGGCGGCGACGGCACGGATACCGCCATCTTCACCGGGACCCGCGCCGACTA
+CACCATCGCCGTCGACACCGACGGCCACCTGACAGTGACCGACACTGGCGGCACCGACGG
+CACCGACAGCGTCAGCAACGTCGAGACCCTGGAGTTCACTGACACCTCGGTGTCCGTCCT
+GACGGTCACCGAGACCGGGGCCAACGGCACCTACAGCTCGATTCAGGCGGCCATCGACGC
+CGCTGCCGACGGAGACATCATCTACGTCGCCGACGGCACCTACACGCAGACAGGCACCCT
+CAATGTCGACAAGGCGGTCACGCTGATCGGCCAGAGCGAAGCCGGCGTCGTCATCGACGC
+CAGTGCCGTCCACGGCTATGGCATCCTGCTCACCGCCGACGGCGCGACGCTCTCGGACTT
+CACCCTGAACGGACCGCAGGGCGGCGATGAAACCGTCTGGTCCTCCTACCGCGTCGACTA
+CGGGATCAAGGTTTCGCCGAACGGCACCGCCTCCTCGCTCTCCGACATCACCCTCCAGAA
+CCTGACCGTTTCGGGCTCGCACAACACGGAGATCGACTTCAACGGCATCCACGATTCGAC
+GCTGAGCAACATCACCGTCGATGGCGGAACCGGGGTCGCCGGCAACGGCATCTCGCTGAC
+CGACAGCAGCAACATCACCGTCAACGACGTCACGGCGGCCAACAACCCCTGGGGCGGCGT
+CGCCATCTATACCGACGGCACCCACTACGCCGGCGGCTCGGACGGCGTCACCTTCACCGG
+CGATTACACTTACGACGCCGGCTCGACCGGCGCCTCGCCGATCTACATCCAGGCGACCGG
+CAACACCTACCCCGTCACCAACCTGACCCTGCCGGACGGCTACGACTTCGCCGTGACCAA
+CAGCGAATACCGCGCGGACGGCAACGAGTTCACCTTCTTCTTCACCAGCGAGAGCGACGC
+GACGGCCTTTGGCAACTCGCTCGGCGCCGGTTCGTTCGTCAGCACCCCCGATGCCGACAC
+CCTCACCGGCACCGCCAACGCCGACTATCTGTACGGCGGCGGGGGGGACGACCATCTTTC
+CGGCGCCGCCGGCGACGACCGGCTGGTCGGCGGCAGCGGCAACGACACTCTCGACGGCGG
+CGACGGCATGGATACCGCCGCGGTCGAAGGCAACCGGGCCGACTTCACCTTCACCGACGA
+CGGATCCGGCCACCTGGTGATGAGCGACACCCAGGGAACCAACGGCACCGACACGGTCAG
+CGGGGTCGAGACCCTGTCCTTCACCGACGGCAACGTCCTGGTCGTCGGCGCCGGCAGCGA
+GTACGCGACCATCCAGTCCGCTATCGACGCGGCGGCCTCCGGTGACACCATCGTCATCGC
+CGGCGGCACCTACGCCGAATCCCTGTCGCTGGACAAGGCGCTGACCCTGCAAGCGGTGTC
+GGGCGCCGATGTCGTCATCGATCCGGCAAGCGGCAACGGCCTGACCGTCAGCGGCGACCT
+CGCCGGCGGCGACGTGACCGTGAGCGGGCTCACCTTCACCGACGGCACCATGGGCATCCA
+GGTGGCGGCGAACGCCGACGTCGGTACGCTGACGCTGGACGGCGTGACGGTCGAGGACAA
+CCTGCAATACGGCCTGCGGACCGATTCCGGGTCGATGGCCGCCGTGATCGTCACCGACAG
+CACGTTCGGGGACAACGGCACCCAGAACGTGAACGGCTCCGCCCAGATGAAGCTCTACAA
+CTTCGACGGCGACGCCACCTTCACCCGGGTCGACCTCGTCGGAGCGCCGGCCGGGACGGA
+CCAGAACAGCCGGCCCGACTACGGCATCGAGCTGACCGGCCTTTCCAACACCGGGCTGGC
+GGAAGGAGGCACGTCCCCCGACCTGGGCACCGTGGTCTTTACCGACGTGACCGTCTCCGG
+CGAATTCCACAAGATCGGCGTCGCCGTCTACAACTACGGCCAGATCGACGGCCTGGATAT
+CCAGAGCCTCGACCTTTCCGGCACCGAGACCAACTGGGGCCCGGTGTTCAACATCGACGG
+TGTCGAGGACAGCACCGTGGATGCCCGGAACTACAACATCACATACCCGGCGGGCGACGC
+CATCGTCGCCGAGCTGCAGGGCGAGGTCCCCGACCAGACCGCCACCGACACCACGATCTA
+TGGCACCGACGCCAACGAGCGCCTGATGGGCAAGGCGGGAGACAACGTGCTTCATGGCGG
+CGGCGGCAACGACGAGCTGTACGGCGCCGACAAGCCGGGCAACCCGGCGGAAGATGACAG
+CGGGAACGACAAGCTCTACGGCGAGGCGGGCGACGACCTGCTGGCCGGCGGCGCCGGTGC
+CGATATTTTGGATGGCGGCGACGGCATCGACACGGCCAGCTATGCCCGCGCCGGCGCCAC
+CGAGGGGGTGGCCGTCGACCTGGCGAACGGCACGGCCAGCGGCGGCGACGCCCAGGGCGA
+CGTCCTGAGCAATATCGAGAACCTGGTCGGCTCGTCCTATGACGACACCCTGACCGGCGA
+CGGCAACGACAACGTGCTGACCGGCGGCGCCGGGGCGGACGCCCTCGATGGCGGCGACGG
+CAGCGATACGGTCAGCTATGCCGGCTCGTCGGCGGCGGTCAACGTCGACCTTGCCACCAA
+CACGGTTTCCGGCGGCGACGCCGAAGGCGACATCCTGAGCAACTTCGAAAACGTCACCGG
+CTCGTCCCATGACGACACCCTGAGCGGCACCAGCGGCGACAACGTGCTGGTCGGCGGCGA
+GGGCAACGACACGGTCGTCTACACCACGACCGTCGCCGCCAGCGACGTCAGCTTCGACAC
+CGACCACTGGGTGGTGACGACGGCCTCCGCCGGCACCGACCAGCTTTCGGGCATCGAGAC
+CATCGAGCATGGCGGCGGCAGCAATATCCTGCTGGTCGGCGGCGGCGGCTACGCCACCAT
+CCAGGCGGCGATCGAAGCCGCCGGCGCGGGCGACACCATCCTCGTCGCCCCGGGTACCTA
+CGCCCCCTTCGCCACCTCGTTCGGCGGCCCGGCGAACATCACCGTCCAGGCCATGGGCGA
+TCCGGGCGACGTGATCATCGACGCCACCGGCGGCGCGCCGTCCAACGGCCGTATCCTCGA
+CCTGCGGGCCGACGGGATGACGCTGGACGGGTTCACCATCGAGGGACCGGGCCACGCCGG
+CGTCGGCATCTCCATCAACGGCCAGGGCATCACGGTCGAAAACAACGTCATCAGCAACGT
+GCTGACCGGCATCCAGACGGGCACCCAGTACGACACCGGGAACGTCACCATCACCGGCAA
+CACGGTGGACGCGGACTACGGCATCAGCCTGCAGAACACCGCCAACACCGTCACCGACAA
+CACGGTCCATGCGACGACGGAGGGACTTGGTGTTCTCGACGTCGCCGCCACCCTGAGCGG
+CAACAGCTTCACCGTCGACGCCGGCGGCGAGGGCCTGGCCCTGTATGGCGGCGCCACGTC
+CTCGACCTTCACGACGTCGGGCAACACGGTGACGGTCGGCGAAGGCGCCAACTTGCAGCA
+CGCAACCGATTTAGCGGGCACGGACGGCACCCTCAACATTGGGGCTGGCACCTACGAGCA
+GGTGATCAGCATCGCCAAGGACGGACTAACGGTGAATGGCAGCGACGCCACGCTGGTGGT
+CGACGGCAGTTCCAGCGACGTGAACGGGATTGCCCGGGTCGATGCCGTTACCATCTACGG
+CGACAACGTAACGCTCCAGGGTCTCACCATCGTCGACTCATTGGTGGATCAGTCCTACGT
+CACCTACGGCTGGCCCGAAACCACCCGAGGCATCGTGGTGAAGAACGGCGCCGAGAACTT
+CACCCTTACCGGCAATACCATCGAGAGCACCCGTAACGGCATTCTGATCAATGGCATCGA
+CAACACGGGCAGCGTTACCGACAACGTCATCGACAACACCAAGAGCGGCATCTCGGTCCA
+ATACACCGACGCCAGTGGCATCATCATCGCCGGCAACCAAGAGGGGACCTACGGCAACGA
+ATGGGGCCTCAACCTGCACCTGAATGGTTACTGGGACGGCACCACCTACACCTCCAACAA
+CGCGGACAACTATCCGATCCTCGGGACAGCGCCAACGGCGGACTGGCAAGCAAGCCTGCT
+CGGCCTGAGCACCGGCAATGACGGCTGGGCCGTCATGGACCAGGCCTACGCCTTGTACAA
+CCGCACTCTGGTAACGGTGGATCCAGACGGCTCGCCGAGTTCGTTCAGCAACCAGGGCAG
+CCAGCGGTCGCCGATCAGCACCATCCAGAACGGCGTCGATCTCGTCGTTGCCGGCGGCAC
+CGTCCATGCCCATGCCGGCGACTACAGTGGCGAGTCGGTCACCGTGCATGTCGACAACCT
+GATCCTCGACGGTGACGCTGGCGCCACCGGCATCACCGTGCAACTGGCCGACGGGCTTAG
+CAACCTGACCCTCGCCGGCGAGGCCGACTACACGGCCACCGGCAATGCGGCGGACAACAC
+GCTCATCGGCGGGGCCGGCGACGACGTCCTGACCGGCGGCGGCGGAGCGGACACGCTAAC
+CGGCGGCGACGGCAGCGACACCGCCAGCTATGCCGCCTCGGCGGCGGCGGTGGATGTCGA
+CCTCGGGAGCGGAACGGCTTCCGGCGGCGACGCCGCCGGCGACACGCTGACCAGCATCGA
+GAACGTGATCGGCTCGGCCTACGACGACATGCTCACCGGCGATGCCGGCGACAACGTCCT
+GCAGGGCGGCGCCGGGGCGGACTCTCTGATCGGCGGCGCCGGCAGCGACACCGCCAGCTA
+CGCCGATTCGAGCGCGGCGGTCGACATCGACCTGGCGGCCGGCACGATCGCCGGCGGCGA
+CGCGGTGGGCGACACCTACTCCGGCATCGAGAACCTGACCGGCTCGGCCTACGCCGACAG
+CTTGACCGGCGACAGCGGCGACAACGTGCTCACCGGCGGCGCCGGCAACGACACGCTGAC
+CGGCGGCGCGGGCAACGACACCATCGACGGTGGTGCCGGCACGGATACCGCGGTGCTGAG
+CGGCAACCGGGCGACCTACACCCTCGGCGTCAATGCGGACGGCAACATCACCCTGTCCGG
+CGAAGGCACCGACGTGGTGAAGAACGTCGAAACCCTTCAGTTCGCCGACGACTCGGCGTC
+GATCCTGGTGGTCGACCCCGGCACAAGCGGTGCCTACGCCACCATCCAGGCGGCGGTCAC
+CGCCGCCTCGGCCGGCGACATCATTCTGATAACCGGCGGCACCTACACGGAAAACGTCAC
+CCTCGACAAGCAGGTCACCCTTCTGGGCGCCCAGGCCGGGGTCGACGCGGATGGCCGCAC
+CGGCGTCACCGAGAGCGTGATCGAAGGCAACATCACGGTTTCCGGAGCGGCGGACAACGC
+CACCATCGACGGCCTGACCATTCACAACGGCGCCTCCGTCGGCGGCGACCTGGCGGGCGT
+CTATCTGGCATCCGGCGCCACCGGCACCGAAATCACCAATACGATCTTCACCCGCGACGG
+CACGGTCGACGGCGACAGTTCCCGCGGCATCCTCACCACCTACAACGGTGGCAACACGGA
+TGTGACGATCGCCCACAACAGCTTCTCCGGCTGGGCCACCGGCACCTACGTCAATCCGGG
+CTCACAGGACATCCAGATCACCGACAACCAGTTCGACGGCAACTACGTCGGCCTGTCGGT
+GGATGGCCCCAACGGCGCGGTCGTCACCGGCAACAGCTTCACCGGCAACCAGTTCGAGGG
+CCTGGGCATCGGCCCGGGCACCGGGATCTCGGGCATCACGCTGTCGAACAACAGCTTCGC
+CGACAACGCGTCGCAGGTCGGGGTCTATACCGACGCGATCGACGTCAACGCCCTCTCCGG
+CAACACCTTCGACGGCGCCGTGGTCATATCGGGCAGCGATACCGTCTATGCCTCCATCCA
+GGATGCCGTCGACGCCTCGAGCGACGGCGACACCATCCTGGTCTATCCGGGCGAATACAG
+CGAGCTCGCCAACTACAACCCGACGACCGGCGAGAACAGCGGGACCGGCAACCCGCTCGG
+CCTGCTGATCAACAAGAGCGTGACCATCCAGGGCGTGACGGCCGACGGCACCTACATCAC
+CGACGCCGGCGACGTGGCCGCCACCGTCACCTCGGGCGCCCAGTCCAACTGGGGGACCAA
+CTTCTTTGTTACCGCCGATGACGTGAGCATCAACGGACTCGACCTGGTGGCGACCGGCAG
+CACCGGTCAGCCCTATGTCAACAAGTCGATCGAGGTCGTCGGCGACGGGTTCACCCTGAA
+CCACAGCGTCCTCGGCGCGGCCGACGGGCTGCCGATGTATACCGCCGTCTATGTCAACGA
+CTGGTCGGTGGACAGCGGCTTCACGGCTTCGGCCATCGCCAGCTATGCCGTGCTGAACTC
+CCAGCTTTACGGCGACATGGTCGTCACCAACGGCCCGGGAACCGGTTATACCGCGGACCA
+GTTGGACATGCGGATCGTCGGCAACAGCTTCCTGACAATCGATGGCGGCATCCCGAACGA
+CGGCATCCTCGTCACCGGCAACGACGACAACATCGCCTGGCGGAACGCCTCGGCCGCGCT
+GCCCACCGAGATCAGCGGCAACGACTTCGGCGACGCCAGCGGCGTCCTCTGGGTGCGCGG
+CGACGGCACCCAGGACTTCCCGACGACGGCGGAGGTCAACGGCATCCTCGCGGACAACAG
+CGTCCCGGCCTATGCCTATGCGGTGGACGGCAACGGCGACCTGGCGGCGGGCACCTACGG
+GTCCTCGTCGATCCCGTCGCTGGCCATCCGTGCCACGGCCGCCGACTTCGCCCCCAGCGA
+ACTGTCGGGAGCCGGCGCCGAGAGCCTGATGGTTCAGCAGGCCGGCGAGACCACGCCGCA
+CAGCTACTCGCTCATCGTCGGCGCCGACGGCGTCGCCGATAGCCTGACCGGCACCAGCGG
+CGACGAGGCGCTGATCGGCGGCTCCGGCGACGACAGCCTGTCGGGCGGCGGCGGCAACGA
+CATCCTGGTGGGTGGCGACGGCAACGACACGCTGACCGTCGGCGACGGCAGCGCCGTCGT
+TTACGGCGGCGACGGGACCGACACGACGGCCTATTCGACGACCGTCTCCGCCGACGACAT
+CAGCTTCGACACCGACCACTGGGTGGTGAACACCAGCTCGGGGACCGATCAATTGACCGG
+CGTCGAAGCCATCGACACCGGCGGCAGCAACAAGATCCTGCTGGTCGGCGGCGACAGCGG
+CTACGCCACCATCATGGAGGCCGTCGACGCGGCCTCCGCCGGCGATACCATCTTGGTCGC
+CCCGGGTACCTACGAGCCCTTCTCGATGGGCTACTGGAGCCCAAGCGACCTCACCATCCA
+GGGCATGCCCGGCGCGGTGATCGACGCGACATCCATTTCGACACCCGCCCGCATCGTCGA
+TCTGACGGCCGAGGGCACCACGTTCAGCGGCTTCACCATCGTCGGACCGGGCGACGTCGA
+CGACGCCGGCATTTCCGTCGGCATCTCCATCTCCGCCCAGGGCGTCACGGTGTCGGACAA
+CACCATCAGCGACATCACGACCGGCATCCAGAACCATACCCCGGCGGATCAGACCGGAGC
+CTCGTCGATCCTCGACAACACCATCAGCGGGGCGAACGTCGGAATCAGCCTGCAGAACGT
+CAACAACACGGTTTCTGGCAACACGGTCACCACGGTCGAGGCTCATACACTCGGCGTCGG
+CGAGGTCGCGCTCGGCGTCCTCGGGGGCGACAATACCATCACCCACAACACCTTCACCGT
+CAGCAACAGCGGCAAAGCCATCGGCCTGCCGGACCTGCCCGCCGTTGCCAATCTCACCAC
+GTCCGAAAACGTGGTGACGGTCGGCGAAGGCGCGGACCTTCAGAACGCGGCCGATCTGGC
+CGGCACCAACGGCACGCTCCACGTCGGCGCCGGCACCTACGCGCAGGAACTCACCATCAC
+CACCGACGGCCTGACCGTCACCGGCGACGACGGAGCCACGATCCAGGTCGCCGATCCGGG
+GGTCTATTCGCCCTCGAGCGACGCCTTCGCCGCCCGGACCATCGCCTTCACCATCGCCGC
+GACCGGCGTGTCCGTCTCCGGCTTCGAGATCAACGGGCCGCTGAGCGCCTATACCTACAC
+CACCACCGACTTCGCGACGCTCGGCTATACCTACGGTTTCTTCATCAACGACGGCGTCCA
+GAACACCACCCTGCACGACATCACCATCCAGGATATACGGACCGGGATGTCCTTCGAGGG
+CGACAACACGGCCACCGTCTATGACAACGTCATCGACAACACGCGCGGCGCCTTCCTGGT
+GCGTTCCGACGGTGTCGACCTGCACGACAACAGCTTCGGCAGCACCGGCAACGAGTGGGA
+TCTGACCATGCTCGCCGGCACGCCCAGCGACTACTTCGGCGATCCGCTGACCGACCCCGG
+CACCTACGGCGACAACATGATGGCCCTGTCGGCCGCCAACAACGACATGACGATCGCCGA
+CCGGATGTACGGCGAGGGCGGCGTGCTGGCCCGGGCCGCCAGCGATCCGGACCTGGCCGA
+CCAGTACGCGGCGGTCGCCAACCGCTCGCACGTCGAGGTCCTGGCCGGCGCCGACAACGA
+CACCAGCGCGGGCCTGGGCGAAACTCGGGGCAACGGCTTCGGCACCGAGCGCCTGCCCGT
+CGGCACCCTGCAGGACGGCGTCAACGCCGTGGTCCAGGGCGGCTCGGTCCACGTCCAGGG
+CGGCGACTACAGCGGCGAATCCGTCACCGTCCATTCCGACAACATCACCATCAACGGTGA
+AGCCAGTGCCATCGGCATCGACGTCCATCTGGGGATCGGGCTGTCGGCCATCACGCTGGA
+AGGCAGCGCCGACTTCACCGCCACCGGCAACGATCTCGACAACACGATCACCGCCGGGGC
+CGGCGACGACATCCTGTCGGGCGGCGACGGCGCCGACATCCTGTTCGGCGGCGACGGCAA
+CAACACCCTGACGGGCGGGGACGGGGCCGACAAATTCATGATCTCGGCCCATACCGACGG
+CAGCAAGGACACGATCACCGACTTCGGCCAGGGCGACTCCCTCGACTTCCACGACGTGCT
+GAGCGACCCGACCGACGTCGTTTTCACGGACGACGGCAGCGGCAATACGCAGATCACGAC
+GAATGCCGCCCCGACCATCGTCCTCGCCGTGGTCGAGCATGTCGAGCCGGCAAGCCTGAC
+GGTGGACGATCACGGCAACGTGACCCTGGCCCAAACCAGCTGACGGCAAAAGGGGGGCGA
+AAGCCCCCCCTTTTCCGTTTGGCCGTGCCCGGTCGTCAGGATTCGGGTTTCATCCAGTCG
+GCGATCAGTCGACGGTAGATGTCGGTTGCCTCGACGATGCGCTCGACTTCGCAATACTCG
+TCGGTCTGATGGGCCATGGACGGTTCGCCCGGGCCGAGCACCAGGGTCTGGATATCGCCG
+TAGGCCGGCGTAATGACCGAGGCATCGGTGAAATAGGCCACCGATTCCGGTGCGAACGGC
+TGTTCCGTGACGGCCGCGACCGCCGCCGCGGCCCGCTGCACCCAGGGAAGTTCCGGCTCG
+GTCCAGATGCCGGGCAGATCGCACAGGGTTTCCAGGTCCGCCCCCTCGCCGATCACACCG
+CCCAGCCCGTCGCGCAGGGGGGCATGGTCCATGCCGGGGATGGTGCGGATGTCGATGCCG
+ACGGTGGCACGGTCGGGCACCGAGTTGACGTTGAGGCCGCCGCTGACCGTACCGACGTTG
+AGGGTCGGCCGGCCGAGGACGGGATGACGGGCGACGTTGAAATCGAAATCCGCCAGCCGG
+CCGATCGCTCGCGCCGCCTTGTAGACGGCGTTGTCGCCGTGCTCGGGCATCGAGCCGTGC
+GCCGTCACGCCATGGGTGATCGCCTTCAGCCACAGGGCTCCCTTGTGGCCGACGCAAATC
+CGGTTGGCCGTCGGCTCGGCGACCACCAGGGCGCCGGCCCGTCCCAGATGCCCCCCGTCG
+GCCAGGGCCCGGGCGCCGTCGCAACCGGTCTCCTCGCCGGCGGTGATCACCAGCTCGACG
+CCGGCACCGTCGCCGATCCGTTCGGCCTCGGCGATCGCCGCAACGACGAAGGCGGCGACG
+CCGCTTTTCATGTCGCTCGATCCCCGGCCGTAAAGCCGCCCGTCGACGATTTCACCGGCG
+AAGGGATCGTGCTTCCACGGCACGGCCCCCAGGGGCACGGTATCGATATGTCCGGTAAAG
+GCCAGCGGGAGGCGCTGTTCCGTCGGCCTGCCCCGTCGCGCGACCAGGCTGGCCCGGTCG
+TCGCCGAGCGGATGAAGGACGCAATCGAAGCCGGCCCCGGCCAGCAAGTCGGCGAGGAAG
+GCGGCGCAGGCCTGCTCCTGTCCCGGCGGATTGATGGTTTCGAAGGCAACCAGGCGGCGG
+GTCAGTTCGACGGGATCGGGAATTTTGGCGGGCATGGTCCTATCCGAAATAGGCGGCGTG
+CACTTCCGGGTCGTTCTGCAGGGACGCCGCCGCTCCCTGCGCGACCAGTCGCCCGCCCGA
+CACCACGTAGCCGTAGTCCGAAATGGCCAGGGTCTGATGGACGTTCTGCTCGACCAGGAA
+GACGGTTATACCGCGGGTGCGGATGTTTTCGATAATGCGAAAGTTCTCCTGCACGTATAG
+CGGCGACAGGCCCAGCGAGGGCTCGTCGATCATCAAAAGGCGCGGCGCGCCCATCAGTCC
+CCGGCCGATCGACACCATCGCCTGCTCGCCTCCCGAAAGGGTGCCGCTCAGCTGGTTGCG
+GCGCTCGGCCAAACGGGGGAAGGTCTGATAGACGTCCTCCAGAGAAGTCCTGATCTTCGC
+TTCCGACGGCTCCTGGTAGGCGCCGAGGCGCAGGTTCTCCTCCACCGTCAGCTTGGAGAA
+CATGCGGCGCCCCTCGGGAATGCAGGCAACGCCACGGGCCACGACCTTGTGGGTCGGCAG
+GCCGGTGGTGTCCTCGCCGAACAGGCGGATGGTGCCCTGGCGCGGCGGGGTCAGGCCGAG
+GATGGAGCGGATCAGCGTCGTCTTGCCGGCGCCGTTCGATCCCAGCAGGCAGGTGATCTG
+CCCCTTCGGCACGGTGAGGGATACGTCGAGCAGGACATCGGCCTTGTCGTAACCGGTGAA
+CAGCCCCTCGATCTCGACCGCCACGTCCGCGGTCTGCGGCACGGCGGCGCTATCGGAAAC
+CGCGGATGAAACGGCGGTCATGGTTGCACTCCCTCCCATTCTCAGGCCGATCCCAGATAG
+GCTTCCTGGACCAGCCGGTCGCTCGCCACGTCCTGGTAACTGCCTTCGGCGATCTTGCGG
+CCATAGTTGAGGACCACGCAGTGGTCGCTGACCCGTTCGATGACGCCCATCTCGTGCTCG
+ATGATGATGATGGCCAAGCCGTCCAGGCGATCGCGCACCGACAGGATGTCGTCCATCAAC
+TGATGCGTCTCGTCGTGGGTCATGCCGGCCGACGGCTCGTCGAGCAGCAGCAGCTTGGGG
+TGGGCGATCAGGGCCCGGCAGATCTCGATGCGACGGCGCTCGATCATCGGCAGGGCGCCG
+ACCGGGTCGAACAGACGGTCGGCCAGATTCCTGCTGAAGGTCGCGACCAGTCCGCGCGCC
+TCCTCCAGGGCCTCCTCGTACTGGCGTCGGAAGGCCCGCCGGCGGAACAGGTTGAACAGC
+AGGCCGTGCTCGAGACCGCCGTAGTTGCCGATCATGATGTTGTCGAAGGTGTTCCTAGGC
+TGTTTCCTGGTGGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTGAGTATTCTATA
+GTCTC
+>NODE_6_length_29555_cov_90.739_ID_11
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+CACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGTTGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCACCCTGATGCTGGGCGGATT
+GGCCTTAATCCAACCTTGAGTAAACGCATTTTCAACGTTAGCAGCTTCATTTTCCCGGAT
+GGTAACCGGTTCTTCATTGATAGACAGCACGCATGATTTTTCGCACGGTGCCGGACAAAT
+CCTGCCGGTAATTTCCGGGAAGCTGTTGGTGGAATGCAGAATCTCATAAGCCACTTCCTC
+ATTACCACGATAATAGGCATCCTGCCATTCGGGAATTTTACTCCCTACAGGACAGCCCCA
+GTGGCAAAAAGGCACGCCGCAATCCATGCAGCGCGAGGTCTGGAGTTTGCGATCCTCCTC
+ATTCAGCGTTTGTTCTACTTCTCCAAAATCGTATATCCGTTCGTTCCGCGGGCGATAAGA
+AGCCTCTTTTCTCGGAACCGTCATAAAACCTTTCGGGTCGCCCATTTTATATCTTATTTA
+ACTTATTATCAATCAATTTATTACTCCTGCATCACGTTAGCATCTTCCGTCATTTTCATT
+TTCTGCTCAAGCTCTCTCAGCTCTCTTTCGCGAAGTACTTTACGATATTCATAAGGAATA
+ACCTTCACGAACTTGGGCAGATATTCTTCCCACTGTGTCAGGATTTTTGCAGCCTTTGGA
+CTTTGCGTGTAAGTCAGGTGCTTACTAATCAGTCCCTGAAGTTCTTTGATGTCTTTTTTA
+TCTTCTACTTCCAACAGCTCAACCAGCCCTTTGTTGCAGTAAAAATCAAAGTCACCGTCT
+TCATCCAGCACGTAAGCAATTCCACCGCTCATTCCGGCTGCAAAGTTTCTTCCGGTTTTT
+CCCAGAACAACAACCCGGCCGCCCGTCATATATTCACAACAATGGTCGCCGGCTCCTTCG
+ATAACCGCTTCCATTCCGGAGTTTCTGACGCAAAAGCGCTCACCGGCTACGCCCTGAATA
+TACGCTTCTCCGCCTGTAGCTCCATAAAATGTGGAATTACCAATGATGATATTTTCTTCA
+GGTGTAAAGGTTGAACCCGTGGGCGGAACCACAATAATCTTTCCCCCGGATAATCCTTTT
+CCGATGTAATCATTAGAATCGCCCTCCAGGCGGAAGGTGACTCCCTTTGCCAGAAAAGCA
+CCAAAACTCTGACCTGCTGAACCGTCAAATGTTGCATGAATGGTATCTTCAGGAAGCCCG
+AATTCGCCATATTTCTGAGAAATCACTCCTGATAACATTGCACCTATTGCCCTGTCTGTA
+TTGGCAAACGGATGATGTAACCAGACTTTTTCTTTTCCTTTAATGGCCTTTCCGGATTCT
+TCAATTAATGTGTGGTCAAGATGACCGTCCAAGTTCAGAGAAGCGGAACCCGGAACATAA
+CGAATATCGAACTTGTCAGCTTCTGCCGGACGGTTCAATACAGCCGAAAAATCAACGTTT
+TTCATTTTCCAACCAAACACCTCCTTGTTTTCTTCCAACAAATCAGCGCGTCCGATAATA
+TCATCAAACTTTTTGAAGCCCATCTCAGCAAGCAACTCACGCACTTCTCCGGCCAGGAAC
+CGGAAAAAGTTAATCACCAGCTGCGGATTTCCTGTAAAACGCTCTCTCAAAGTTTCATCT
+TGAGTTGCAATACCAGTCGGACAAGTGTTTAAATGGCATTTACGCATCATGACGCAGCCG
+AGGGTGATGAGTGCAGAAGTAGCAAAACCGAACTCTTCAGCCCCCAGACAGGCCATGGTG
+ACAATGTCGTGTCCGTTTTTGAGTTGTCCGTCTACTTGGATTTTAACACGACCGCGTAAA
+TTGTTTTTTACCAATGTTTGTTGTGCTTCCGCGATGCCAATTTCTACCGGAAGTCCTGCA
+TGTTTGATGGAACTGATAGGACTTGCTCCCGTGCCGCCTTCACCACCTGAAATAATGATC
+AAATCAGCGAAAGCTTTAGCCACACCGGCAGCTACAGTGCCCACGCCATCCTGGGAAACC
+AGTTTCACAGAGATTTTAGCTTTTGGATTGGTGGCTTTCAAATCATAAATCAACTCCGCC
+AAATCCTCAATGGAATAAATATCATGATGAGGAGGCGGTGAAATCAAGGTAATTCCAGGC
+GTTGAATTTCGCAGCTTGGCAATCACTTCATTCACTTTATAACCTGGCAACTGACCGCCT
+TCACCCGGTTTTGCTCCCTGGGCAATTTTGATTTGAATTTCACGAGCGTTTGTCAAATAG
+TTACTTGTGACACCAAAACGTCCGGAGGCAATTTGCTTAATAGCACTTTGTTTCTCCGTA
+CCAAACCGGTTGTGGTCTTCACCACCTTCACCTGTGTTACTGCGTCCACCAACCGTGTTC
+ATGGCAACAGCCAGCGATTCATGAGCTTCCTTGCTAATAGAACCGTAGGACATAGCGCCT
+GTAACAAAGCGTTTCATAATTTCTTCCACAGGCTCGACTTCTTCAATAGAAATGGAATTG
+CGTTTTACCTGAAAGCATCCTCTGATAAAAGAAGGTTTCCGGTTGTACTCATCCACAGTC
+CGGCTGTATTCTTTAAATTTTTCGTAGCTGTTGGTACGCGTGGCCCATTGAAGCAGTCCG
+ATAGAATCCGGATTCCAGGCGTGATCTTCTCGATTTTTGCGCCATGCGTAAACTCCGGTT
+GTTTCAAATCTGAATTTCTCTTGGGTGGCTTCTTCACGAAATGCATCCTTATGGAACTGG
+CTGTATTCTTCGTAAATTTCTTCCAGACCAATACCACTGATGGGCGAGGAAGTTCCTTTG
+AAATATTTGTCCACCAGCTCTTTACTTAAACCAAACGCTCCAAAAATCTGAGCGCCGTGA
+TAACTTCTTACTGTTGAAATTCCCATTTTCGAGAATATCTTCAACAGACCTTTTTTGATG
+GATTTGATATAATTTCTGCGGGCATCTTTGTATTCCATGTCCAGCTTGCCCTCTTTCACC
+AGGTGATCGACAGCAGCAAAAGCCAGATAAGGATTGATGACACTGGCTCCATAACCCAAA
+AGCAACGCATAATGATTCACTTCGCGGGCCTCACCGGTTTCTACAGCAATTCCCACCTGC
+ATCCTTTTCTTTTTCTGAATCAAGTGGTGATGTACGGCCGAGACCGCCAGCAATGACGGG
+AAGGGGGCATGTTTTGAATCAATGGCCCGATCAGAAAGAATGATGAAATTCTTTTTGTCG
+TCAACAGCTTTTTCAGCCCTTTCCAGCATCTCATCAAACGCTTTCTTAAATCCTTCAAAC
+CCCTGATCTACCGGAAAGACTATCGAAATGATTTCGTGGGAAAACATTTCATCTTTCAGA
+TCTTTGATTTTTCCAAGGTCGGTGTTGGTAACGATGGGGTCGGGGAATTTGATGAGTTTA
+CAGTGGTCGGGGCTTTCTTTGAGGATGTTGGAATTTAAAGAACCGATGTAGTTGGTAAGC
+GACATGACCAGGCCTTCACGAATAGCATCTATAGGCGGGTTAGTGACTTGGGCAAACGTC
+TGCTTAAAATAATTAAACAGACGCTGGGGTTGTCGTGAAAATATCGCTGCCGGTGTGTCG
+TTACCCATGGAATTGATAGGCTCAACGGCCGTGTTGGACATGGATTGAATCAGGAATTCC
+ATATCTTCTTTAGAATAAGAGAAGACCTTGGCGTAAGTGAGAAAATCGTCCATAGTCGAC
+GGCACCCGTTGTCGTACTTTGATATCTTCCATCAGTAAACGATTTTCCTTCAACCACATT
+CCATAAGGATTGCGACGACTAAGTTGTTCTTTTACCTCTTCGTCAGGAATAATGATGCCC
+AGCCGCGTGTCTACCAGCAATATTTTTCCGGGACGCAAACGTCCTTTTTCTAGAATTTCT
+TCCGCTGCAAAATCCTGCACGCCGGTTTCCGAAGCCATCACAATTAAATCATTTTTGGTG
+ATGACATACCGCGAAGGACGCAAGCCGTTCCGGTCGAGCGTTCCACCAATGTATCTGCCA
+TCAGAAAAAACAATGGATGCCGGCCCGTCCCAGGGTTCCATGATGGTGGAATGGTATTCG
+TAAAAAGCTTTCAAGCTTTCCGGGATAGGATTCTTTTCGTTGAAAGATTCAGGAATCATC
+ATGCAAAGACTGTGGTGCAGCGAGCGGCCTGTACGATGCAGAAATTCCAACACATTATCA
+AATGATGCAGAGTCTGATTTCCCTTCTTCCAGTACAGGAAGAATTTTCGGTAAATCATCT
+CCAAAAACTTCAGATTTCAACAGCCCTTCACGGGCTTGTGTCCACAAACGATTTCCTTTG
+ATGGTATTAATTTCACCATTGTGGGCCACCAGACGGAAGGGTTGTGCCAAATCCCATGTT
+GGGAAAGTATTGGTACTGAATCGGGAGTGAATTAAAATCAGTGCCGATTTAAACAACGGA
+TGTTGCAAATCGGTAAAATAGTCTTTCATTTGATCCGGCGTCAACATCCCTTTATAAATC
+ATCGTTTTCGCCGAAAGGCTCGAATGATAATAAACTTCTTTTTGTGAAAGGTCGGAAGCT
+TGTACTGCCTTTTCAGCCCTTTTTCTGACGATATACAATTTCTGTTCAAGGATATCTTCT
+TCAAGGTTGGCCTTGATAAAAACTTGTTTAATGCGCGGTTCTGTAGTGCGTGCAATTTCT
+CCCGGGATGCTACTATCAGTAGGAACATCCCGATACCCAATCAATTGCAGGCCTTCTTCC
+TGGATGATATTTGACAAAATATCAACACAAGCATTTGCTTCTGCTTCTAGCTGAGGCAAA
+AAGATCAAACCGGTTCCATAGCTCCCTTTCGCAGGGACATCTATTTTCAGTACCTTCTTA
+ATAAATTCGTGAGGTATCTGCACCATGACACCGGCACCATCACCACTGGCATTATCCGAA
+CCCTTGGCGCCCCTGTGATCCAAATTCCTGAGTACCTCCAGCCCTCTTTCTACAATATCA
+TGCGATGCCTCTCCTTTGATGTGGGCAACAAAACCTATCCCGCAATTATCATGCTCATTG
+GCGGGATTGTACAAACCGTCCGGTTTTGGAAATCTAAACGCCATTTCCTTCCTCTTTTTT
+TCCATTCTAAAAAATTCCTTTCTTGTGAACCGACTTTAAGGTCAAGGATAAATCCGCCCG
+GGTTTATCCTATTTCATCTCTACGCTACAAAACCACCTTCACACAAAATGGTTTCCAGTT
+CCTTTTAGGTTTAAATCCTCTTAATCCTCCAAAATCTCTGCCAGGTCGGCTTTGAGATTG
+TTACGTTTTCACATATTCAAAAATACATATTTCAATAGGGGTTGGTCAAGACGGGCGAAG
+GTGACCAGAATTTCGCCCATAAAATTTTAAACCCTTTTTATCGCTATAATTATTTATTTA
+TCAACTTTTTAGTAGAATTATTTGACTATTTGACAATGAATAGTACAAATGGCATCGTGC
+GAAGGGAAAGATAATTTTCGCAAACGATTTACCTGCAACAAATAAAAGTGCCGGAAAAAA
+TTTAAACGAATCGTTAAAAAAATATAAGCTTTAAGCGGGAAAGCCATCGAAAAGAGGGTT
+AACTTGGCAATAAATAATACTTTTGGCATCTAATTATCATTCATCATGTTGGAACAAAAA
+GAACTGATTCTTTTAAACATTTCGGGCGAAGACAAACCGGGATTAACAGCTTCACTGACT
+GAAATTCTGTCGCAACACAACGTCAATATTCTTGATATTGGACAGTCTGTAATCCATAAA
+GATTTAGGATTGGGTATTTTGTTTGAAGTCCCGAAAAAGTATCGTTCTGCCAGTATTTTG
+AAAGATCTACTGTTTAAAGCCTATGAATTGAAAAGCCATATTAAGTTTACTCCGATTCCC
+ATCGAAGAATACGAAAAATGGGTGGCGGAACAAGGAAAAGAACGTTTCATCATCACCTTA
+CTTGCCCACAAACTAACAGCACTGCATCTTTCCAAAGTTTCAAGTCTGATTGCCAGTCAG
+AAGTTGAATATCGATACAATTTCCAGGTTATCCGGCAGGAAGTCCTTAAACGGGAATAAC
+AAAGTAACCAACTCTGTGGTTGAATTTTCAGTTCGCGGAACTCCTCTGGATATCAATGCC
+ATGAAACAGTCGTTGATGAATATTGCATCCGAAACCGGCATTGATATTGCGTTTCAGGAA
+GATAATATTTATCGCAGAAGCCGTCGTTTGGTTTGCTTCGATATGGATTCCACACTGATT
+CAAACGGAAGTAATCGATGAGCTGGCACAAAAAGCAGGCGTTGGCGATGAAGTGAAAAAA
+ATTACGGAAAGTGCCATGCGCGGTGAAATTGATTTTAAAGAAAGTTTTAAAAAACGGGTT
+TCATTGCTCAAAGGTCTGGATGAATCTGTGATGAAAGGAATTGCTGAGAATCTGCCGATT
+ACAAACGGTGCAGAAAGATTACTCAGCACGCTGAAACAATACGGTTACCGGACAGCTATT
+CTCTCCGGAGGTTTTACTTATTTCGGAAACTACCTGAAAACCAAGCTCGGTTTCGATTAT
+GTTTTTGCCAACGAACTGGAAATTAAAAACGGGAAACTAACAGGAAAACATTTACATGAA
+ATCGTGGATGGAAAACGAAAAGCTGAGTTATTAGAACTGCTGGCTTTCAAAGAAGATATC
+CATTTAGAACAAGTGATTGCTGTGGGTGATGGTGCCAACGATCTTCCCATGCTGGAAAAA
+GCCGGGTTAGGAATTGCTTTTCATGCCAAACCCAAAGTAAAAGCATCGGCACAACATGCT
+ATTTCCGCTACCGGATTGGATACGATTCTGTACCTTCTGGGTTTCCGTGATAGAGAAATT
+AATGCCTCATGAAGTTCATAAAGTTGGAGTTCCTTACAAAAAGTGTATGGGGGATTTTTC
+TATTTTCGTGCTGGAATTCTGTTGAAAATAATTGAAGTTTTTTTCGCTACAGGATTAACT
+TGTATTATGCGAAAATCAGTAGTTAATCAGGCATTCTTTTAAAAAGTAAGGAACTAATAT
+CCAATATATTAAGATGGAAAAACTAGTTACATCAGATTTTAAACTGGGAATTATAGCAGG
+CGGACAACTTGCCAAAATGTTGATTCAGGAAGCCAGCAAATGGGATATCATCACTTACGT
+TTTGGACAATGATGAAACCTGTCCGGCGAATAGTCTGGCAACGCATTTTGTCAAAGGAAG
+TAACCTGGATTTTGATTCGGTGTACCGGTTTGGGAAAATGGTTGATCTCCTGACTTATGA
+AATGGAGAATATCAATATTGAAGCTTTGAAAAAGCTCAAGTCCGAAGGCCATCAGATTAT
+TCCCGATCCGGATATTCTTGAACTCATTCAGGATAAAGGAAAACAAAAGGAATTTTATCA
+AGATAACAACGTACCTACGGCGCCTTTTAAAATCTATAGCAGCCGACAGGATATTGTACA
+AGCCATAAAGAATGGCGAAATCAAATTCCCGTTTGTTCAGAAATTAAGAACCGGAGGATA
+CGACGGGCGTGGGGTGGCTGTTATTAGTGATGAAAATGATTTGGATAAATTACTTGACGG
+TGCTTCTATTATTGAAGATAAAGTCAACATAGCCAAAGAAATAGCGGTGATTGCCGCCCG
+TAATAAACAAGGAGAAATAAAATGTTTCCCCGTAGTTGAAATGGTATTTGACCCTGAAGC
+AAACCTCGTGGATAAACTGATTTGTCCTTCAAAAATTACCGCCGAACAATCGGAAAAAGC
+CATTGAGATTGCTGGTAAAATCATCGGTTTACTCGGAATGCAAGGATTGCTGGCCGTTGA
+GTTTTTTGTTGATGAAAACGGGGAAGTCATTGTAAATGAATCTGCTCCGCGTCCTCACAA
+CAGCGGGCATCATACCATTGAAAGTATTATTACTTCACAGTTTGAACAACACTTACGTGC
+CATTTTTAATTTACCTTTGGGTAGCACCAGACCCAAACTTCCTGCTGTCATGGTAAATAT
+TTTAGGAGGTGAAGGTTATGAAGGTCCGGTCAGGTATGAAGGATTGACTGAAATTATGGC
+CATCGAAGGTGTGAAGATTCACCTTTACGGGAAGAAAATAACCCGGCCGTTCAGAAAGAT
+GGGACACATTACCGTGTTATCAGACTCCCTGGAAACTGCGCTGGAAAAAGCTGAAAAAGT
+TAAACAATTAATAAAGGTAAAATCGTGGGACAAAAATTAGTAAGTATCGTCATGGGTTCA
+GATTCCGATCTACCCGTCATGAAGCCGGCTGCTGAAATGCTGGAACAATTGGGTGTCGAA
+TACGAAATTGACATCGTATCAGCGCACAGAACCCCGGAAAAATTATTTGATTTCGCTTCC
+AACGCACACAAACGTGGTATTCAAGTTATCATCGCCGGTGCGGGCGGGGCTGCTCACCTG
+CCGGGCATGGTTGCATCCATGTCACCCTTGCCGGTTATCGGCGTACCGGTAAAATCTAGC
+AACTCCATTGACGGCTGGGATTCAGTACTTTCCATCTTACAGATGCCCGGTGGAGTTCCT
+GTTGCTACGGTAGCCCTGAATGGTGCCAAAAACGCGGGCATTCTTGCAGCTCAAATCATT
+TCTGTATCCGACAGCCAGGTAAGAGAAAAAATTATTGAATACAAAGCCGGACTCAAAGAA
+GCCGTCATGAAAAAAGCTAAAAACCTGAAAGGATAGAACAGCTTTTTAGAGAAACTTTTC
+AGGCAAAACGGCAATCAGGTTGTTGACGACCGGTTCGTGTCATCACAAATTGCCAGAGTT
+GTGTGGCACGTGAGCGAAAACCACCGGCGCTGCTCAACAAATAATAGCGCCACATCCTGT
+AAAACCGTTCATCGTATTGGTTTTTCAATTCCTTCCATGCTTTATTAAAACGGTCGTACC
+AGGCCATTAATGTTTTATCATAATCGGGGCCAAAGTTGTGAAAGTCCTCAATGACAAAAT
+AAGGCTCGGCTGCTTTGGCAACCTGGGCAATGGAAGGCAGCATTCCGTTAGGAAAAATAT
+ATTTATTGGTCCACCGGTTCACATAATGCGTCGTTGTATTATTTCCAATTGTATGCAGCA
+GCGAAATGCCGTTATCCGTCAGACAACGGTCAACAATTTTCATGTAAGTATCATAATTTT
+TGTAGCCCACATGTTCAAAAAACCCGACGGAAACAACGGCATCAAATTTACCTTCAACAT
+CCCGGTAGTCCTTGTAAAGCAAAGTCACCGGCAAACCTTTACAAAGTTCATTACCCAGCT
+CGATTTGTCTCTTTGAAATGCTCACCCCCAGCACTTCCACGCCATATTTTTCGGCTGCAT
+ATTTGGCAAAGCTTCCCCAACCGCAACCGATATCCAGCACTTTCATGCCCGGTTTCAGAT
+TTAGCTTTTTACAAATTAAATCCAGTTTGGCTTCCTGGGCCTGATCGATGTTTTTGGCTC
+TTTGCCAGTAACCGCAGGAATAAACCATGCGCCTGTCCAGCATTTTACTGAACAACTCAT
+TTCCCAAATCGTAATGCTCGCGACCCACCCGCTTCGATTTGACTCTGGTTTGTTGATTAA
+AAAGCCGTTTGGATAAAACATAAAAAGCCGTACTGAAATTCCTTTTGACTTTTTCTTCCA
+GTCCGGCCCGTAAAATCCTTTCAATGAATTCATCCAGGGCTAAACAATCCCACCAACCGT
+CCATGTAAGATTCGCCCAAGCCTAATTCGGCTTCGGAAAGCCATCTTTCATAGGCTCTTT
+CATCATGAACTTGTACGTCATAAGGATGCGGTCCGTTCAGGTGAACACCTGTACCGGTCA
+GTAATTCCCGGATAACAGTTTTCGGATCCATGGGTTGGATATTTTGCGGTTCTCTTCAAA
+GGTATGAAAATATGGAGTTCATAAAGTGACTAAAGTGCGCTAAAGTCCATAAAGTTGAGG
+ATGCTAGCTTCAAAAAAGCTTACTCCCCAAAGGCACTTCCTTATCGGGAACACAAAGCGC
+TACACGGCCTTTTTCATCTGCAAATCCGGTGGTAAGACATTCGGAAAAGATGGGTCCGAT
+TTGCTTTTTCGGGAAATTTAAAACGCCAACTACAAGTTCACCAACCAATTCTTCAACAGT
+ATATAATTCCGTGATTTGTGCGCTGGATTTTTTGACACCGAATTCAGGGCCAAAGTCCAC
+ATGCAAAATGTACGCAGGTTTCCGGGCTTTTTCAAAAACTTCGGCCTGGACAATTTTTCA
+CACCCGAAGCTCGACCTTTTCAAAGTCCTTCCATTCAATGAGTTCCATAAATATTCATTC
+TGAAATTTTTGGTGATTCTTTTTCTTCAGCAGCTTTAGATTTGACTTTTTCAGTACCACA
+TTTATATAAAAGCCAGCCTACAAAAGCCCAGAAAAACGGAAGTAAATAAAAACGCACATA
+TGTCCAGGTATAAAAACCCAATTTAGACCCTGTGTGATTAGCAGGCGGCTGCATAACCGG
+AGGTTTTCCATAAGCTAAATTTATAAAACCATTTGCTGCTAATAAAAAGAAAATAACAGC
+AACTATTATCATTATTATTCCGTAGCGTTTCGAATGTTCCACACTTTTTAATCTTAAAGG
+ATTAATAAAATTTGCCGACCAATTTGTTCGGAGAAACAAAATTAACGTTTAGCAAACAAT
+TTCCAAGATCGGCTGATGCAACATTTGCTGAAAAACTTTTAAAATGATTTTGCTTTTATG
+TATTTGGTGTTTCTTCTGAGGCCTCATTTACTTTTTCTATCCCAAATTTCAATAATAACC
+ATCCTCCAATAGCAATAATAACAGGGGTAACATAAAACCCAAAAAATTCACCTGTTTTAT
+AAGGAATATCATCATATTTAAATGGAGCAGTAAATGATGGATGGCCTGCCGGAAGTTTTG
+AAAAGATTATATGATAAAAGCCAACAGCGGCAAATAAAAAAAGTAAGCCTGAAATTAACA
+TGGTAAAAGTACCATACCTTAATGGATGTTTTTTCATAATTTTTGTTGTTTCAAGAGTGA
+CTTGTTAAAGACGTTTGCAAATTAAAATACCAAAAAACAAAAGGCTGTCCGCCTGAGGCG
+GACAGCCCTTTGTTAAAAATCATTTATTAATTAGTTCCGCCTGCGTCATTTCCGCTTGGA
+TAAGCCGGAATTTCTGCCGGTGGTTGTGGGATTGGCATCGGATGCTCTTTGAGCTTCTTC
+ATGATGTAGTTGATGGCAGTATCAAGCTGAGGATCTTTTCCTTCCATTACCTGACCCGGA
+AGGTTATCCACCTTGATATCTGGTGTAACACCATGATTTTCAATAGCCCATTTCGAATCA
+AGTCCGTAGATACTGTTCTGCGAAACCACAAGGTTTCCACCATCCAGAAGTGTCCATACG
+CGGTTGTAACCACGAACACCACCCCAGGTTCGTTCGCCAATTAACGGCCCTAAACCATAT
+TTCCTGAAGTAGAACGGGAACATATCGCCGTCTGATGCCGAATAATGGTTCAGCAGGCAA
+GCTTTGTATCCGTGCAGCACTTGCTCAGGATAACGCATAGCTGCGTGAGCTCTGTTGGTG
+CTCATACCAATCAATACGCGGCGCAATCTTTCCAGCACAATCTGGTCGATAAATCCACCA
+CCATTGAAACGGTCGTCCATAATCAAACCTTGTTTGCTAAGCTGCGGATAGAATTGATGG
+ATAAACTGAGTCATACCCAAAGATTCCATATCGGACATGTAGATGTAACCGATTTTTCCG
+TCAGATTTCTTGTTGACGTAAGCACGTTTCGTCCTTATCCAATTGAGCAAACGCAAATTC
+AGAGAATTATTAATCGGTTTCACGGTAACGGTATGTTCTCCTTTACCGTCAGGTTTATCA
+GCCAGGGTCAGCGTAGTTTGCTGTCCCACAGTGTTCACAAACAAACTGTAAGGATTCATC
+GGTGCTTTCAGCTGATGACCATTCACAGCAAGCAGATAATCACCGGTTTTCACATTAACA
+CCAGGCCTGTCAAGCGGAGAGCCATATCCCGGACGGGAATTATCACCAGCATAAATTTTC
+TTGAAATAATAACGACCGGAAGATTTGTTTAATCCGAAATCAACACCAAGCACGCCGGTT
+GGGTTTGTTTTGCCCAGATAATTATCATCACCACCCCAGACGTAACAGTGTGAGTTATCA
+AGCTCACCAATCATCTCACCTACAAGATAATTCACATCTTCGCGGCAACCCAATAATGGT
+ACCAGTTTACCGTAGTTTGCTCCCACTTCATTCCAGTTCACACCGTTCATTTTGGTGTTG
+TAGAAGAAGTTATTGAAAAGCCGCCAAGCCTGATGGAACATCTCACTCCATTCCTGATGA
+GGATAAATCTTCATTTTCATATGGGAAGTGTTTACAGGCTCACTGCCTTTTGCATTTACA
+GAAGCCGAAGGCATCAGGAAGAATTTACCTCTTCTCATATAAACCAAAGTTTTTCCATCA
+GCACTCAGTCCGTAAGTTCTGGCACCGTTTGCCACTACGGTATGGCCCTTTTTACTCTTC
+AGGTCGTACACCATAATAGAAGACTGACCGGTTCCATGTAAGAAACCTTCAATTGTTATC
+AATGGACGTGTTTGATAAAAGACTTTGTTGCCGGTTACCTGAATATTTCCATAATCACCC
+GATTTAATCGGAAGCATGATAACCCGGTTCATCAATCCATTGAAGTCTATTTTAACATCT
+TTAGCACTTTCTGTTTTTTTCGAAGCGGAAGAAGAAGCTTTCTTTGCTTCAGGCATTCCT
+TCGTCGGAAACCGGGGCAAAAGGAGATTTCTCATTTTTTTGCAAGGTTACCATATAAATA
+CCGTCCATTTTTTCAGTAGCAACATTGGATTCGCTTTCGCTGAAAAGCGGATTTTCGTGA
+CGTGCAGAAACAAAGAACAGATATTTTCCATTGGGGCCAAACACGGGATCATTATCAGAA
+TATATTCCGTCACTTACTTTGTAGGATTTGTGATCGGCCAGACTGTAAATATAAATCTGT
+GAAAGACCACTAGCATTGGTCTTGCTGTAAGAAATCCAATTGTTATCAGGTGACCAGTGA
+TAATCCCTCATAGCGTTGTATTTATCCTGTGCAATCCGAACCGGTTTTTTATCTTTTAAA
+CTGATATACCAAAGAACGTGATTGTTATCAGAGTAAGCCAGCATTTGGCTGTTTGGAGAC
+CAGGTAGGATTGTAGTAATATCCTGTTTTAGCGTTTGTTATATAAGTTTGATGTCCTGAA
+CCATCAGAAGGACGGATGGCCAGTTCATTGACACCGCTGGCATCTGTCAGGTAAGCAATC
+CATTTGCCATTGGGTGACCAGGCAGGATATTGTTCCTGAGCATCAGATGTTTGTGTAATA
+TCGCGGGTAGCGCCGTGTTTGGCAGGTACGGTGAAGATATCACCACGTGCACCAAAGAGA
+ACGCGTTTTCCGTTAGGAGAAATATCCAGGCTGCGGATCATCTTGCTGGCATTAATCCAG
+CGCGGGAGTGTCTGAGTTCCGTCAGTAGGAACTTTGACATTGATTTTGTGAAGTTGTTCT
+GAAGGAAGATCCAAAACATACAAAGAACCACCATCCTGGAAAACAATGCCGTTATTTCCC
+AGACTCGGCCAATCCACATCATAATTTTTAAAATGTGTTATTTGACGGAACGTTTTTGTA
+TCTAAGCTATAAGCCCAGATATTCAAACGGTGGTTTGCGCCTCTGTCAGAAGCAAAATAA
+ATGGTGTTTTTATACCACATGGGATACGTGTCGGTACCTTTCCATTTGGTAACCCGCTGG
+ATTTTCTTTGTTTTGAAATCATAAATCCAGATGTCCTGTGCCAAGCCACCTTTATAGCGT
+TTCCAGGTACGGAAGTTCCTAAAAATACGATTATAAGCAATCTTGGAGCCGTCAGGGCTA
+TAGGACATCACGCCGCCTTTAGGCAAAGGCAGGTGCGTTGGCAGGCCACCCATTTTACTT
+ACTTCAAACGGTTGGCCAAACCAGGAATTCCAGGTATCTCTTCTGGAAAGGAATACAATG
+TCTTTTCCGTTGGGTGTCCAGGTCATAACCATATTATCTGGTCCCCAGCGGGTGGGAGCT
+TTTCTCACCACATCCGAGTGATAAGTTAAACGGGTAACAGCGCCTCCGTCAGCGGGAATT
+GTATAAACATCCACATTTCCGGAATACTGACCGGTAAAGGCAATGGTTTTTCCGTCGGGG
+GAAAACCGGGGCATCATATCATAGCCCGGATCGGTTGTCAATCGTGTGGCAACACCGCCT
+GTACGATCAACTCGCCAGAGATTTCCGCCAGCTTCAAAAACAATGGTATTGTTATGAAGG
+GTTGGAAACCGGCAAAGCAAAGTCTCGTTGTTTCCTGTTGTGGCAGCATGAGCCACGAAT
+GGTGCCCCGCCTATTAATAATATCAACAGCAAGGACAACAAATTATAATGACGATTCATA
+ATAAAAAATTTAATGAGTTTATTAAATAAGCTGATCCATTAAGGTTTCTTATTTCTTGAG
+AACCTTCAAAATTAATCAAATTACCTTTCTGACAGGTAACTTTGCATGAGATTTAACGAT
+TAATAACGCTTTAAAGGGACAAGTCCCCTTTTTTTATCGATAAATGCCCCCATAGTTTCT
+ACGTAATGGTTTATTTTGCATAAATATTTTTTGCACATGATTCGTTACAACCTACATCAG
+CACAGTATTTTTTCAGATGGCGCAGCGGAACCCGAAGCCTACGTACAAAGCGCTCTAAAT
+CTGGGGTTTGAGGCTATGGGATTTTCGGAGCACAGCCCCTTGCCATTTCCCACAAAATTT
+AGTTTGAAAGCAGAACGGGTGGAAGATTATATCCGGGAAACAGAACGGCTCAAAGAAAAG
+TACAACGACCGCATTGATTTATACCGGGCACTGGAGATGGATTTTATTCCGGGGTATTCA
+GAAAACTTTACCGAGTGGCGTAAAAAGGCTCAACTTGATTATGCCATTGGTTCGGTGCAT
+ATGGTACAACCGGAAGATGACGGAGAATTATGGTTTATTGATGGCCCCGACCGCTCTATA
+TATGATGACGGACTTCAGAATTTTTTCGGCGGAGACATTAAAAAAGCAGTGAAAACATAT
+TTTCATCAGGTGAACCGGATGGTGGAAACCCAGGATTTTGAAGTTGTCGGTCATGTGGAT
+AAAATCAAAATGCACAACCAGAACCGTTATTTCACAGAAGAAGAAAAATGGTACCGCGAT
+TTAGTGGAAGAAACACTGCACCTGATAAAAGAAAAAGATTTCATTGTAGAAGTGAACACG
+CGGGGGCTTTATAAAAAGAGGTCCAACCGGCTTTTTCCTGATGACTATGCTTTGCAACGC
+ATCAGCGAGCTGGGCATTCCAGTGTTGATTTCTTCGGATGCCCATAAACCCGAAGAACTG
+AACCTGCTTTTTGAGACAGCCGAGAAACGACTATTGGACATGGGATTGGGTGCTGTGGTT
+CGTTTCGACCATGGAAAATGGAAAGATTTTCCACTCTCCTGAAACGCACATTTATACCTT
+AAAATATATAGCTACTGTGTTGTGAAGGAGACGCGTACTGAAGTGCTAAAAAACCCCTTT
+AGAAAAAACATCAAGTTTACAGCTGAATTAATTTCGTAAACAGCATTTTTTGTCAATTTT
+TCAGAATTCGACGCAAAAATTTTCTAATTTGAACAATATTATCAAATGGAAGATTTTCCA
+TTTATTTTTTTACTTTTGCAGCGCTTTCTGAAACCTAAATTGTCGTCATGAGTGAACCAA
+TCGTTAGTATCTTTTCAGGTCGTACAAGCCGCTACCTGGCGGAAAAAATCGCCCAAGCAT
+ATGGTACCCCATTGGGAAAATCTGAAGTAATCAATTTCTCCGACGGAGAGTTTCAAACAT
+CTTACGAGGAAAATGTAAGGGGTCGTGATGTGTTTATCATCATGTCAACACCCCCACCAG
+CTGAAAATATTTTGGAGCTTTTGATGATGATCGACGCTGCCAAAAGAGCTTCGGCGCGGA
+AAATTGTGGCGGTGATTCCTTATTTCGGCTATGCCAGACAAGATCGTAAAGACAAACCAC
+GGGTTTCTATTGGAGCAAAAATGATCGCCAATTTACTGACTACTACGGGAATTGACAGGC
+TAATAACCATGGATTTACACGCCGATCAAATTCAAGGTTTTATGGATTTTCCGGTGGATA
+ATCTTTATGCATCGGTTATCTTTTATCCATACCTGAAAAAGCTGAATCTTCCCAATTTGA
+TGATGGCTTCTCCGGATACGGGTGGCACACGCCGGGCAGCCAACTATGCCAAGGCTTTGG
+ATACCGGTTTTGTAATTTGTTACAAGCAAAGGACAAGACCCAATGTGGTTGAACAAATAC
+AATTGATTGGTGATGTCGCAGGAAAAGATGTGGTTTTGGTTGATGATATTATTGATACGG
+CAGGCACCATCACCAAAGCAGCCCGGGTAATTCTGGATAAAGGTGCCAACAGCGTACGCG
+CTATGGTTACGCATCCTATTCTTTCGGGAGATGCTTTTAAAATTATAGCCGATTCACCAT
+TTACCGAAGTAGTGGTTACAGATACCATCCCGGTAAAAGATGATTTAGGCGGAAAAATTA
+AAGTGTTATCAACGGCACAGTTATTTTCTGAAGTTATCAAAAGAGTTGAAAATTATAAAT
+CGATTAGTTCCCTTTTCAATTTGGGGAACCAATCCAATAAATAATCATTTTATCAAATAT
+TAAGTTATGAACACAGTATCATTGAGCGGTTCTCTTCGCGAGAACGTAGGGAAAAAAGAT
+GCTAAAAAACAGCGCAGGCTGGGTAAAGTTCCTTGTGTCATTTATGGCGGAAGCGAACAA
+AAGCACTTTACATTAGATCAATTGGAATTTAAACCTTTGGTTTTCACTCCTGAAGCTTCT
+GTGGTGAATCTCACCCTGGGAGAAAAAACTTACGAATGCATTTTGCAAGATGTTCAGTAT
+CATCCTGTTACGGACGAAATATTGCATGCGGACTTTCTGGAAATTCATTCTGAAAAGCCG
+GTTAATATTGCATTACCTGTTGAATTGACAGGAACAGCTCCCGGAGTTGTAAAAGGTGGA
+AAATTACGGTTGAAAATGAGGAAACTCCGTGTAAACGGAATCATCAAACTCATGCCCGAA
+CACATCGTTCTGGATATTTCAAAACTGGATATCGGACGTTCCATCAAAGTAAGGGATATC
+AACCAGGCAAATCTTACCTTCCTTGATCCCGGTAACCAGGTTGTGGTAGCTGTTGTTGCT
+GCCCGTGGTCTGAGCGCCGAAGAAGAAGCTGAAGAGGCTGAAGAAGGTGAAGAAGGCGAA
+GCTGCTGAAGGTGGCGAAGAAGGAGGCGAAAAAAGCGCTGAATAATTTTAGAAAACTTTT
+AATAGAAAGGCTGTCTCAAAAACTTCTGAGACAGCCTTTTTTGTCTACGATTGTCATACA
+ATAGTCAGACTGTAGTCAAATGATGGTCAGACAATTGTTTGATAACCGCTTGAAAATTGT
+TTGAAGATTGTCTCTTCTCCTTTTACCCTGCAACCTTTAAACCATTAAACCCTTAAGTCC
+AAAAAAGAAACTTCCATTTCACGCCAATCCCTCGTATCTTTGCCGAATCTTTGATAATTC
+AAAAAAATGAAATATCTAATCGCCGGGCTGGGAAACATTGGGGTTGAATATGCCAACACA
+CGCCACAACATAGGTTTTATTGTGGCCGATGCGCTGGTGAATGAGTTGAAAGGAAAATTC
+GAAACCGAACGGCTGGCGTCGGTGGCTTCCGTGAAACATAAAGGAAGAACACTGGTGGTT
+ATCAAACCCACAACTTATATGAACCTCAGTGGGAAAGCCATAAAATACTGGATAGATAAG
+GAAAAGATTCCTATTGAACGTGTGCTGATAGTGGTGGATGATATTGCTTTACCGCTGGGC
+ACTTTGCGCATGCGAAAAAAAGGTGGGGCCGCCGGTCACAACGGATTATCTGACATCATC
+ATGAAGCTGGGAACGGAAAAATTTCCCAGGCTGCGTGTGGGTATTGGTGATGACTTTGCC
+AAGGGCTACCAGGTTGATTTTGTTTTGGGACAATGGACAGATAAGGAAGTCAATGTGATG
+ATTCCGCGCGTGCAGAAAGCCGTGGAGATTGTTCAGAGCTTTGTGAGTGCCGGCATTGAT
+AATACGATGAATCTTTATAATAATAAATAGTATCATTTTTTCCTGGTTGTTTTCACGAAA
+AGTATCATTTCATTAACTAATTTTAGGCGATAGACACCAACCCAGGGAAACAACATGTCA
+TTTCGAACCACCAGGCAGGCCGGTGTGTTAGCGTGAGAAATCCCCCGGGAGAGAACCTGC
+TGCTCAGGAGATTTCTCCTCACTCCGTTCCTTCATTCGTCGAAATGACAATCTGGTTTTT
+TGGCGAAAAACCACCCCCAAAATACCAACGTCATGAAATCCCACAAGCATTTTAAAACGA
+AACTGTTAAAAAATTTGGTGAAACAGATAATTATGAATAATTTTGCCGCCCAATTTACAG
+TAAGGTGAATAAACATAGTGAGCTTATTATCCCGTTTAAAGGGTTAAGCATCGGAAATCA
+TCATTACGATTTTGTGATAAGTGATTCGTTCTTTGAGAGTTTTGAGCCTCTTAACATTCA
+GAAAGGGAAGATTGACTTATCACTTGATCTTGAAAAGGAGTCCGGATTGCTGTCGCTGCT
+TTTCCATTTCAATGGAATGGTTAGGCTGACCTGTGACCGATGCCTGGAGGAGTATGATCA
+GCCTGTAGCTGATGATTTTCGCCTGATTGTAAAATTTGGCGAAGATTTTCAGGAAATTAC
+TGACGAAATTGTTGAAATTCCGGATACGCAACATCGTTTTGATTTGAGTCAGTATATTTA
+TGAATACATTCAGCTGATGCTTCCCCTGAAACACGTGCATCCTGACGACGAGTTGGGAAA
+CAGCACCTGTAAACCGGAAATGCTGGAGAAGCTCAAAGAACTTTCCAAACCGGCAACCGA
+TCCAAGATGGGATGCTTTATCAAAATTGAAGGAAAAATAAAACAAATATAAAACTGAAGG
+AAAATGGCACATCCAAAAAGAAAAACTTCTAAAACCAGAAGAGATAAAAGAAGAACGCAT
+TTGAAAGCAAATGCCCCTGTTTTGACCACTTGTCCTACCACGGGCGCAGTGCATGTTTAT
+CACCGTGCTTATTATGTGGACGGCGATCTCTATTATAAAGGTAAACTGGTTGCTCAGGCT
+GCTGAAGCTTAAGAACTTTTTAGTCTGCTGAAAAGTTTTTTATCTGTTTCGAGCGACCCA
+AAAACACAGCCTTTGTTCAAAAAAAGACAAAGGCTTTTCTTTTTGGTTACGCTCCGGTTA
+AAAACGCAAAACTTATTGGCATTATGAGTTTTGAGGATTTTAAACAAATCGTATTTACCG
+GAAATTTCATCCGGAAAAAAGTTAGTAAAGGATAGTTCTGTTAATTCAGATCGTGTCCTT
+TTTTTAAAAATGCTATTTTTGTCTCCATCATAATTAAGAAAAGTTCACTATGACCAAAAT
+CAGAGCAGCCATTACCGGCATACACGGATGGGCTCCCGAAGACGTGCTCACGAACAGTGA
+TCTCGAAAAAATGGTTGATACAACTGATGAGTGGATTACCACCCGAACAGGAATCAAAGA
+AAGACATATTTTAAAAGGAGAAAAAGGAACTTCTGATATGGCCGTGGAAGCGGTGAGAGG
+TCTCCTGGAAAAAACCGGGACAAAACCCGAAGAAGTAGACCTGGTAATTTGCGCTACGGT
+GACTCCTGACATGCAGTTTCCTGCTACCGCGAATCTGGTGAGTTATAAATTAGGAATCAA
+TAATGCATTCAGTTTTGACATGAATGCCGCGTGCTCCACTTTTATTTACGCTTTGATTAC
+CGGTTCAAAATATGTTGAATCAGGTGAGTACAAGAAAGTAATTGTAATTGGAGCCGATAA
+GATGTCCTCCATTGTGGACTATACCGATCGGGCTACTTGCGTGATTTTTGGTGATGGTGC
+CGGTGCTGTGATGCTGGAACCTACTGCTTCAGACGAACCGGGCATCATGGACCATCGTTT
+TTATACCGACGGTGCCGGATGGATTCATCTGCATCAAAAAGCCGGCGGTTCGTTGAAACC
+CGCTTCTCACGCTACTGTTGACGCTAAGGAGCATTTTATCTACCAGGAAGGACAACCGGT
+ATTCAAATTTGCCGTAACCCGCATGGCAGATGTTGCTGCTGAAATTATGGAACGTAATCA
+ACTGAAATCGGAAGATATTGCCTGGTTGGTACCCCATCAGGCTAATTTGCGTATCATCGA
+TGCCACAGCCAGACGCATGGGCGTATCGAAAGATCAAGTCATGATCAACATTCAGCGTTT
+TGGAAATACCACCAACGGAACCATCCCACTCTGTCTTTACGAATGGGAACCGCAGTTAAA
+AAAAGGTGATAATATTGTGCTGGCTGCCTTCGGCGGTGGATTTACATGGGGCTCAGTTTA
+TTTGAAATGGGCTTACGACGGGAAGAAATAAATTCCTTTAGGAAATACCAATATTTAAAT
+CACAAATTTCAAACAAATTCCAACTTCAAAAATTCAAATTCCAGGACCGAGGCATTAGGA
+GTTTGATATATTGAAGTTTTGGTAATTATTTGATATTTGAATATTGTTATTTGGAATTTT
+AGGTATTCTACTTTCCTATAGCAGTACTTCCCCTTGCAATCAACTCCGTATCAATAATAT
+GTATTTGTTGATGCATGTCTTCAGGATGTTCGATCCGCTGAATCAGCAAATCCACAGCCA
+CCTGACCTACCCGGGCTAATGAATGATGTACAATGGAAATGGCGGGTTTATACATCTGAG
+AAATCGGACCATCGCTGAAACTGATAACGCCCACCTCGTTCGGAATCTTGATATTCAATT
+CCTGTAAAGCAGGAATAATGCCTGTCAGTACCTCATCACTGATACTCATAATTCCATCCG
+GGTAATTTTTCCTTTTAAAAATTTGCAACGCTTTGTTTCTGGCCATGTGCGAATCATCGG
+CAAACACCAAATCATGTTCTTCCAGATTATAGTCGCTGAGTGCTTTTCTAAAACCCATCA
+GCCTTTGCTGTGTGATGTATAAGGCGGCATTCCCACCAAAATAAGCAATGTTTTTTCTTC
+CCGTTTTAATAAGATGCTCCGTAGCTTCATAAGCAGCCCTTCTATCATCAATAATCACCT
+TTGAGGTTCCGTAATTATTAAAAACACGGTCAAAAAACACCACCGGAATTCCCTCTTTTT
+CAAGCTGATCAAAATGTTTATGGTTTCGGGTTTCCTTCGTGATTGCCACCAGCAAACCAT
+CCACTTGACTGGAAAGCATCAACTCTGTGTTCTGAACCTCCCGCTTATAAGATTCGTTGG
+AAGATAAAATCAATACATTATAACCGGCATTATAACAGAACTCTGAAACCCCGCGAATCA
+TTGAAGGAAAAGCATAAAGTGTGATTTCAGGAATAATCAGCCCGATAATCTTGCTGTAAG
+AGTTTCTCAAACTCAAAGCAAAAGCATTGGGATTATAATGCATTTTCTGAGCCAGCTTTC
+TGATTTGTTCTTTTCTTTCTTCACTGATATCAGGATGATTTCTCAGCGCTCTTGAAACTG
+TGGTATGCGATACTCCAAGCTGTCCGGCAATATCTTTCAAAGTAACACGTCTTCTCCTAT
+TCTGCGTCATTTTAAGCAAATTATGTGCGTGCTAATATAAAGAATATCTGGCAGTTCTGA
+GAAAAGATTCTTTCAAGACACCATTTTCATAAAAGTTATTAACAATATCACACGACTTTT
+CAACAATTCAGGTGTGTGTTCACGTGTGCGGAAAAAACACGGAATAACGACCTTGTGTTT
+CAGTTAATTAATGATATATCTTTACACGACCATTGTCCTATATTCATGAATAATAATGGG
+AATTAAAACAACATGAATTTTGCACCGGCATATCGGATTTTTTCGAGAAAACCTTTCTGA
+GTTGACCAAAAAGAAGGGAAGGTAGAGCAGGTGTTTAGTAAGTATTTTAACCATTAAAAA
+CTTAAGAGAATGAAAAAAGTTGTACAAGCCTTCATGGTATTGCTGGCCCTTACCATAACA
+ACGGGGCTCATGGCGCAGGGGACTATAAAAGGTACCCTGAAAACGACCAAAGGAAAAACT
+GTTCCGGGGGTCAACATCTTACTGAAAGGAACAACTACCGGAACTACTTCCTCACTAAAC
+GGAAGTTTTGTTCTTAAAGTTCCTGCCGGCAAGCACGTCCTACTGGTCTCTTTCACCGGG
+TTTAAACCGATAAACTATTCGTTTACCATTAAAGACGGTGAAACCTTAACTAAAAATTTT
+GTCCTCCACGAAGACCTGCTGGCACTAGACCAGGTTGTGGTGACCGGGGTACAGAATAAG
+CAAACCAAACTACAATCCAGCGTAGCCATTACCACATTATCGCCTCAGAAAATTTCACAA
+ATTGCTCCGCGAAGCGCTGCTGATTTGTTAAAAGCCATTCCGGGATTTTACGTTGAAAGT
+TCAGGAGGTAAAGGAAATGCCAACGTATTTGCCCGCGGACTTCCAAGTTCGGGCGGATTG
+CGTTACGTTCAGTTTCAGGAAGACGGGATGCCTGTATTTGAATATGGCGACCTGATGTTT
+GGTAACACAGACATTATGGTACGTATCGATCAGACCATGTCACGTATGGAAGCTGTCAGA
+GGTGGTTCTGCTTCAGTTCTTACCAGTGACGCTCCCGGTGGTATCATTAATATCATATCC
+AAAACCGGTGGCCCGACAACAAAAGGTGTATTTATGCAGACTATCGGTTTGACCTACATG
+CATGCCCGTACCGATTTTGATATCGGCGGACCTGTTTCGAAACATCTTCGTTATAACATC
+GGAGGTTTTTACCGTGCTGATAACGGAATCCGTTCTCCCGGTTTCCTCGCCAACAACGGA
+GGTCAGATTAAAGCAAACTTCACTTACACGTTTAACAAGGGTTATGTCCGGTTCAGAACC
+AAGATTTTGAATGACAAAACCATTGCTTATCTTCCGTTCCCGATGATGGGGAATCCTGCT
+AAAAGTATTCCAGGATTCAATGCCAATTACGGGACCATGAAGAGTTTGGATCTTTTGCAT
+CTTCACGCAACAACTCCCACAGGAAATTCTGTAAATGAGAGTCTTGCAGACGGAATGCAT
+CCGAAAATTTTCGCTTTCGGAGGTGAAGCATTTTTTGACCTTGGCAACAAATGGTCATTA
+AAAGATAACTTTGAAAAAACTTTTACTCACATCCAATTTAACTCCATTTTTGGGGTGAAT
+GCTCCTGAAAGTGCCAGCGCTTATGCTACCGCCCAAGGACTTACCAATTATCACTATGCT
+TTCGCAGACGGTTATAACGCCGGTAAGCCAATTACCAATATGAGTTCACTGAACGGGAAT
+GGTCTTGTAGCCACTTATGGATGGTGGTCAGTGGGCCTGAACCTCCAGGAATTTGGCAAT
+GATTTTAAACTCACCAAGCAGTCAACAAACAATACTTTTACTGCCGGTTGGTATTTTTCA
+ACCAATCAGGTGGGTGGTAACTGGTGGTGGCACAACATGTTGGTGGACATTTCCGGGCAT
+AACACCCGCAAATTGAACCTCATCAACGATAACACCGGTGAGTCGCTCACAACCAATGGT
+TATTCACAATACGGAACGTTGTACGCCGATTATAATGCATTAACCGTTATCAACGCACCT
+TATGTATATGATGAAATTGACTTGGGACGTTTGACAATCAACGCCGGTCTGCGTTGGGAT
+ATGGGAACAATTACCGGTCGTGTTGAAAACACCGGAAGTTATTCTTATGATGTGAATGGT
+GATGGTATCATCTCACCTGCTGAAAAAAATATTCAGTATGGTAATGGAACTTACACCCCT
+TTCCATTATGATTACAGTGTGTTGTCCTATTCACTGGGGTTGAATTATGAATTCAATAAA
+AGCACAGCCATTTTTGCCAGAGCCAGCCAGGGACACCGCTCTCCGGCAGACCGTGCTTAT
+GTTTTCGGTGCAACCACTTCTACACCCAACGGTTTTCCGTCCAGTGCAAAAGATGAAAGC
+ATCGAACAATACGAGCTGGGATTGAAATATAATTCGTCGAAAGTGGCTTTGTTTGCCACC
+GGTTTCTATAGCTTCTTCAACCACATTGACTTCACTGATTTCGTGAATGTCGGTGGAAAT
+TTAACAGCCATCCAGCAGTATTACAATACTTCTGCTATGGGTCTGGAATTGGAAGCTGCT
+GCACAATTGGGCAAACTGAACCTGTCCTTAACAGGAACCGCACAGAGCGCCAAATATCAT
+AACTGGGTATATCACGATCAAAGTGGTAATCTGCATGATTTCAACAATCATTTCATTCAG
+AGATTACCTAAATTGTACTTCACCTTCAGACCTTCTTATAACTTTGGAAAACTGAATGTA
+AGTGCTGCCTGGGAATACTTTGGCAAACGATACACCAATCCTGAAAACAAACAGGTATTG
+CCTCAGTTCTCACAAATCAATGCTTATATCGATTATACTGTAAGCCCGCATATTACAATT
+TCCGCTGCCGGTAACAATCTGTTTAATGTCATTGGTCTGACTGAAGGAAATCCGCGTTCA
+GGACTTGTAAGCACAGGTGGAAGCCAGTATTTCTACGCCCGTTCTATACTGGGCCGTTCT
+GCAATTTTGTCTTTTAAGTATAGCTTTTAATTAATAAAAACTGTCCTTTTCATTTTTATC
+GCTTTATTTCACAAGCTGTTAACTTTGTAAATAAAAAATAAATTTCACAACGATTTATTT
+TAGAAAAAGTGAAATAAAGCAAAGACAAATAACATGTTGATTCTTTTCATAGAGAAGCCG
+GGTAGGTTTCTCTATGAAAAGGATTTTATAAAAAGTCAGTGGCTGGTTGAGAACATGAAA
+TGATGCCTGGTTCATCTGATAAATAAAAATAAGCACGTGAAACATATTGATATAAGCCCC
+ATTGATATTGCCATCATTGTAATTTATATCGTGGGAATCGCCGTTTGGGGATTAATGTAC
+AGTAAGAAGAAGTCGAAGGGCAAAGGCCATGAAGGCTATTTTCTGGCTGGAAGAAACATG
+ACCTGGCCCATTGTGGGAATCACGTTGTACGCAGCTAACATGGGTAGCCCGGCGTTGGTT
+GGGCTGGCTGGAGATGCTTACAGCACAGGGATTTCGGTATTTAACTACGAATGGATGGCC
+CTGGTAGTACTCGTCTTTTTTGCCATTTTCTTTTTGCCGTTTTATTTGAGGAGCCGGGTT
+TATACCATGCCCGAGTTTTTGCAGCGGCGGTTTGATATTCGTTCACGTTATTATTTTTCA
+TTTATCACGCTGGTCGGAAATATTATCATCGATACAGCTGGAGTCCTCTTTTCAGGAGCC
+CTAATCGTCAAGATGATTTTTCCGGCGATGGCATTGTGGCATATTATTGCTGTTCTGGCA
+ATTATTACGGCAGCTTATACCATAACAGGAGGACTTTCCGCAGTGATGTACACCGAAGCG
+GTTCAGGGTGTTTTACTCATGCTTGGCGCCGTATTATTGACCTTCTTCGCGTTGAAACGA
+ATTGATTTCAACGTGGCACGCATCTTTACTGAAACACCTCATCACATGATGAGTCTTATC
+AGGCCCAACAGCGATAAAGCCATGCCCTGGCTTGGACTTGTGCTGGGCGTTCCACTGCTG
+GGCTTCTATTTCTGGGGCACCAACCAGTTTATGGTTCAGCGTGTTCTCAGTGCAAAAAAT
+ACAAATCACGGCCGTTGGGGCGCGTTGTTTGCAGGTATCTTAAAATTACCCGGTCTTTTT
+ATTGTTGTTTTACCCGGAATTATTGGACGCCTCATTTTTCCTCATCTCTCCGACCCTGAT
+TTGATTTATCCTATGATGCTATTCCACCTGCTTCCGGTAGGTATTCTGGGAATTGTGCTG
+GCGGGTTTGATTGCCGCAATCTCATCGAGTATCAGTGCGACACTAAACTCTGCAAGTACA
+TTGATGACCATGGACTTTGTCAACAACCTAAAACCGGGGCTAACCCCAAAACAACTCGTA
+AGAATCGGGCAGATTTTTACAGGAGTTTTCGTGGTGATTTCCGCGGCATGGGCACCGATG
+ATAGCAGGATTCCCTTCATTGTTTAAATACCTGCAACAGGTGTTGGCACTTATTTCGCCA
+CCCGTTGTGGCTGTCTTTTTACTGGGTCTTTTCTGGAAGCGGGCCAATGCTCAGGGTGCT
+TTCTACGGTTTGATGGGAGGACTGCTCATGACCATTTTTGCAGTCATTGTCAGGTATGTA
+AATCCGGATATTTTCCCGTGGCTGGGACACATCCAGTTCTTGCTGGTAGCTCCGGTTTTG
+CTGGTGGGAACCATGGCCATTATCGTTCCGGTTTCACTGATGACACCGCCGCCACCGGAG
+GAAGCTGTGGCACAGTTCACCTGGTCGTTTAAATTCTTCAATGCCGAAAGTATGGAACTG
+GCCGGAACACCCTGGTATAAAAACTATCGTTATCAAGCCATTGGCGCATTATTAGCAACG
+GCTATTTTGGTTTACATTTTCAGGTAGAAACTTCAATGGAGGAAGCAAAAAACACATATT
+CCAAGGCCCTTGACCTGTTAAAAAACGGATTGCTGAAAGAAGGGTTTGTCGCTGCACTGG
+ACCAGCAGGCTAATTACCGGCGTGTGTGGGCCCGCGACAGCATTATTACCGGCCTGAGTG
+CCTTACTTGCAGATGACACTACATTAATAGAAGGAATGAAAAAAACGTTGATTTCATTGA
+AACAACACCAGCATGCCAATGGTATGATTCCTTCCAACGTGTCTTTTGATGCTGATGGAA
+ATGTCACCATGGTGAGTTACGGTACCCTTACGGGGAAGGTTGATACAAACCTTTGGTTCA
+TCATCGGGGTAATGGTTTATGTAAGAAAAACTAGTGATACGGATCTCTTGAAAGAAATGC
+TTCCGGCTATTGAAAAGGTCTTTGAGCTTTTGCTTTCCTGGGAATTTAACGGGCGTGGAC
+TACTGTACGTTCCTCAAGGTGGAAATTGGGCTGACGAATTCATTTTGGAAGGTTATAACC
+TTTCTGAGCAGCTCTTGTACTACTGGGCGTTGTCAGAAGCATCTGCCATGGATGAAAAAT
+TTTCAACCAAAGCCAAGAAACTGAAAGACCTCATAGAGATAAATTACTGGCCCACAGAAT
+CCAATCGTTCTAAAGTATATCACAAAACCGCTTTCGAACGCCAATTAGAAAAAGGGCAAA
+CCAGTCATTGGCTGCCCGGATTCAAACCGGCGGGTTATCATACTTTTTTCGACTGTTTTG
+CCCATGGCTTGTCTTTTGTTTTGCAATTCAATTCGCCGGAACAAGAAGGGGAGATTATTG
+AAACGCTGGTCAGGACCACTAGTGAAACATCAGGATCCTTGCTTCCGTCTTTCTGGCCAC
+CTGTCAGGGAAACGGATGCACAGTGGGAAACCTTGCAAACCAATTGGATATACAAATTCA
+GAAATCAGCCCGGCGCTTATCAAAACGGTGGAATCTGGCCGATCTCCAACGGTCTTTTGA
+TTGCCGGATTGTATCGTTCGGGCCATAAAGGCATGGCCGACAAGATGAAAGAGGCATTAT
+TTCTGGCAACAGCATTGCCGGAAAATCAGTTTGGATTTTACGAGTACATCGACGCATTCA
+GCTGGGAGCCCGGTGGGGCCAAACACCAACTGTGGTCTGCGGCCGGTGTCATCTTTGCCG
+AAAAGGCTGCTCAAAATGTTTTTATTGTTTGAAAGGAGATTTGAGATTTATGGAAGGAGA
+TATTATAAATCTAAATGATGAGCACCGGAGCACGGCAAGAAAAATAGTAGCTCCGCTTAT
+CGAAGAAATAAAAAATTGTCAAACCATATATACGTTTTCCGTTGCCGGTGAATCAGGTGC
+CGGGAAATCCATCACAGCAGCCGCCATTGCGGAACAGTTGGAACTGGCCGGATTTTCCGT
+GAAAGTTTTTCAGCAGGACGACTATTTTTTCCTGCCTCCGTTTACCAACGACCAGAAACG
+CAGAAAAGATTTGGAATGGGTGGGTATCAAAGAAGTGGACCTTGCCCTGATTGACGAACA
+TCTGAAAGCCGCAAAAGACGGCGTTAAAACCATCAAAAAACCACTGGTCATTTATGGTAA
+AAATAAAATTACTTCAGAAGTATTTGACATGAAGGGCGTGAATGTTTGCATTGCAGAAGG
+AACCTATACTTCGCTTTTGAAAAACGTTGACAAACGTATTTTCATCGACCGTGATTTTTT
+TGACACCCACAACGACCGGAAGAAACGGGGTCGCGATTTAATCGACCCTTTTACCGAAAA
+AGTGCTTGAAATTGAGCAGTGTTCCTAGGCTGTTTCCTGGTGGGATCCTCTAGAGTCGAC
+CTGCAGGCATGCAAGCTTGAGTATTCTATAGTCTC
+>NODE_7_length_23944_cov_113.632_ID_13
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+CACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGATGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCACCTTTGGCCATTCGGCGGA
+GATGGATTTGGAGATTTTGGCGTAGCCGTAGCCGGGAAGGTCCGCGAAGAGGAAGTTTGG
+CTGCTGGCGGTTGGGCGAGGTAGTGAGGCTGAAAAAATTGATGGCGCGGGTGCGTCCGGG
+CGTGGAGGAGACCTTGGCTTGGCGTGAGCCAAGCAGCGCGTTAATGAGGCTGGATTTGCC
+AACGTTGGAACGGCCCAGAAAGGCGAACTCGGGTGCCGATGGCGGAGGGAAATGAGCCGG
+GGCGGTGGCGGAGAGAAGGAACTTGGGATAGACCTGCATGCAGGTTTCAGTATAGGGCTC
+GGGCGCGGAACCGGTAGTCTGGAGCGATGAAGGTGAAAAAGGTCTGGTTGAGCTGGAGCA
+GCGGAAAAGACAGTGCGTGGGCACTGCACATTCTACGGCAGCAAAAAGATGTGGAAGTGG
+TGGCGTTGTTGACGACGTTGAATGAGCACTTCGACCGCGTGGCCATGCACAGCACCAGGC
+GCGACTTGGTGGAAGCGCAGGCGCGGGCAGCGGGGCTGCCGCTGGTGCGGGTCCCGCTGC
+CATGGCCTTGCTCGAACGAGCAGTACGAAGCGGCGATGGGTAAGGCGTGCGCGAAAGCTG
+TGGCGGAAGGTGTGGAAGCGGTAGCCTTTGGGGATTTGTTTCTGGAAGACGTGCGGCAGT
+ATCGCGTGGAGAAACTGGCTGGAACGGGACTAGAGCCGTTGTTCCCGTTATGGGGGCTGG
+ATACGCGGGCACTGGCGCGGGAAATGATCGCCGCAGGTGTGAAGACTCGACTGGTGTGCG
+TGGATCCACGCAAGATGCCTCGGGAATTTGCAGGGCGTGACCTAGATGAGGCGATGCTTC
+GGGAGCTGCCGGAGGGAGTGGATCCGTGCGGCGAGAACGGGGAGTTTCACAGCTTTGTGT
+ATGGCGGACCGATGCTTGGGGAGGAAATCCCGGTAGAGAGCGGCGAGGTGGTGGAGCGCG
+ATGGGTTTGTCTTTGCGGATGTGAAGCTAAAGCACTGATGGGCGTCGGTTTCGGCTCGCG
+CGAGGAGGCTGGGCGCTGGTAGACTCTCCTGTTTTGAGTTTTGTGCAGAAGGAGAGGAAT
+CGTGAGCGAAATCCAGATTGTAGGTGTAGTGGGAGCGGGCACGATGGGCAATGGGATTGC
+GCACGTGTTTGCAAAGAGCGGCTTTCAGGTGCGGCTGTGCGACGTGGAGCAGAGGTTTCT
+GGATCGTGGCATGGATACGATCCGGAAGAATCTGGGGCGCGAGGTGACGAAGGGCAAGCT
+TATGCAGGAAGAGGCCGATGCAGCGGTGAAGCGGATTGAGGGGACGCTGGCCCGCGCGGC
+GCTGGCCGACTGCGACCTGATTGTGGAGGCGGCGACCGAGCAGTTGGAGGTAAAGCGGCA
+GATCTTTGAGGATCTGGACCGGGTGGCCAAGCCGGAAGTGATTCTGGCGAGCAATACCTC
+GTCGATCTCGATTACCAAGCTGGCGGCGTTTACCGAGCGGCCGGAGCGGGTGATCGGGAT
+GCACTTTTTCAATCCCGTGCCGGTGATGAAGCTGGTGGAGGTGATTCGCGGGCTGGCGAC
+GACGCAGGAGACCTTCGAGATGGTGAAGGCGCTGGCCGAGCGGCTGGGAAAGACTGCGGT
+GGAAGTGAACGATGCTCCGGGATTCGTTTCGAACCGAGTGCTGATGCCTCTGCTTAACGA
+GGCCATGTACGCGGTGATGGAAGGAGTGGCGACGCCGGAGGCGGTCGACCAGGTTTTTCA
+GCTGGGGATGGCGCATCCGATGGGGCCGCTGACGCTGGCAGATTTTATCGGCCTCGATGT
+GTGTTTGGATATCATGCGCGTGCTGCAGGAGGGGCTGGGAGATCCCAAGTATCGGCCCTG
+CCCGCTGCTGATCCGGATGGTGGATGCCGGATGGCTGGGGCGTAAGAGCGGACGCGGATT
+TTTTGAGTACGGCAACGCGTAAGGTATTGGCCTGAAGGCGGATCTGCCCGGCCGAGGTGG
+CCGGTATGGTTCGGCGGCGGGCTTTTCGCCGAGTCTTCCACATCGTGTCTGGCGTATTCT
+CGAAGCTATGGTTCGGATGACAGTGCTCGCCAGTGGTTCGAAAGGCAACAGCACCGTTGT
+CTCCAGCAGCCGGACACGCCTACTGGTGGATGCGGGGCTGTCGTGCCGGGAGATATTCAG
+GCGAATGCAGGCGGCAGGCGAGGACGTGGAGAGCCTGGACGCCATTCTGGTGACACACGA
+GCATCAGGATCACGTGCAAGGGCTGGCGGTGACGGCGCGGAAGCTGGGGATTCCGGTGTA
+CTTTACCGAGGCAACGCATCGGGCGTGGATGCGCTGGATGACGCCGCGCAAGCGGCTGAC
+CTATGCGCAGTGGCTGGAGCAGCAGAAGGCGATTGTAGCGGCCGGTAAAGAGCCGGCGGC
+AGCGGGAGCCGAGGCCCAGGATGCGGCCGAGGAGGATATCAGCGGAGCGAAGCCGAAGAA
+GGATCCATGTGCACTGCCGGCGGTGGAGTATTTTTCCTCCGGGACAGACTTTCAGGTTGG
+AGACATTGCGATTACGCCATACACGGTGCCGCATGACGCGGCCGATCCGGTTGGATTTGT
+CTTTGAGGCCGAAGGCGTAAGGCTGGGGATTGCGACAGATCTAGGTTATGTAACTCCTAA
+CGTGCATTTGCATCTTAAGAAGTGTGACGTTTTGATGCTCGAGTCAAATCATGACGTCGA
+TATGCTGCGGGACGGGCCGTATCCGTGGTCGGTTAAGCAACGGGTGATGTCCCGCGTGGG
+GCACTTATCGAACGACGCCGCGGCGGATTTCCTGGAGAATTCGTATGACGGACGGGCGGC
+GTTTGTGGTGCTGGCGCACTTGTCGGAGAGTAATAATCTTCCGGAGTTGGCCCGTGTCAG
+TGCTGAAAGAGCACTGCGGGACCGAATGAACCTGCTGGGGAACAAGCTGATGCTGGCCAG
+CCAGCAGACACCTCTGGAACCTATCGTTTTGTAGATAAGTGTGTTAAGCTTCCGGTAAGC
+CCCCTTTGAACCATGGGAAGCTTTCAAAGCTGAAAGAGGGACTCCAAGGGTCGCAGGGGA
+AGGTCAAAAAGAATGAAAACTTGTATTGATCCGGTAGTTGGCGACATTCTTTCGAGTTGG
+CGCTATGACATTTCCGGGATCACTCCCGAGATGCGCATTGACTACGAGGAGCATCTGGCA
+AGCTGCAGCGTATGCCGTTCGCGGCAGCGGCTGCATCGGGCTATTGACGTTGTGCTGATT
+GGCCTGACAACGTTGTCAACAATTGTGTTTGTGCTGGCGCTGGCCGTGATCCACCACGTG
+GAACCATTGCGGACTTTCGCGCTGTTTATCTTCCATATCCGGGATTTCTCGGTAGTGCTG
+ACGCTGCAGGCCGTGGCCTTTGCCGGACTGGTGGTCTCGATGTTTGCCTGGCTGCTGGTT
+GCGGTGGCAACTCCGGTGCCGACGTTCCTGTCCGGAGTAGCGCGTGAGCAGGCACGGGAG
+CTGCAGTCGCGGATTCCCGAGGAATGGCGGAATCGCTTCCAGCGGGGAGCGTTGTAGGCG
+AGAAGATTCGGCAAGTCATGGCGAAGGGCCGGATGGAAATCCGGCCCTTTGCCTTTGCTG
+TGGACCCGGTTTGCGGCTGGGGGTTATTGCCCGGTCTGCATGCCGCCAATCAGCTCTGAG
+ACTTTGGCGATATGGTGGCGGGAGCACCAATGGGCCAGCCCCTGGCCGATGTGCTCAACG
+GCGCGCGGATCTGCGTAACTGGCGGTGCCTATCTGGACGGCAGAGGCTCCGGCGAGAAGA
+AATTCAACGGCGTCTTCAGGGGTGGTAATGCCGCCCATGCCAATGACGGGAATCTTGACG
+GCCTGGGCGGCCTCCCATACCATGCGCAATGCGATGGGCTTGATGGCCGGGCCGGAGAGT
+CCTCCGGTGATGTTACTGAGGCGGGGACGGCGGGTTTCAACGTCAATGGCGAGCGAGACG
+AAGGTGTTGACCAGAGAAATCGCGTCGGCACCGGAAGACTCGGCGCTGCGGGCCATGGTT
+GCTATGGAGGTTACGTTGGGGGAAAGTTTGACGATGAGCGGGCGGCGCGAATAGTGGCGG
+GCATGGGCTACGAGGTCGGAGAGTGCGGCCCGGTCGATGCCAAAGGCAATGCCGCCAGCG
+TGGGTGTTCGGGCAGGAGACGTTGAGCTCGTAGGCCGCGATGCCTTCGGCTTCGTTAAGG
+CGGCGGATGACAGCAATATAGTCTTGCATCTGGTAGCCGAAGATGTTGACGATGACGGGG
+CACTGATAACGGGCCAGGGCTGGGAGCTTTTGTTGGACGAAGGCATCTGCTCCAATGTTC
+TGCAGGCCAATGGCGTTGATCATGCCGGCGGCGGTTTCAATCAGGCGTGGTGCCGGGTTG
+CCGGAGAGGGGTTCGCGCGAGATGCCCTTAGTGACAAATCCGCCAATATGGTCGAGGTTG
+ACGACGTCTTCGAATTCAATGCCATAGGCGAAGGTTCCGCTGGCGGCGAGGACCGGATTG
+GGCAACTGGATGTCGGCAACTTCGACGCGCATATCCACGCCGTGCTGGATGCCGCGTGTG
+GCGCTCATGATCGCCTCCGGTAGATGGCGGCGGAGCAGGCCAAACAAGAGATGGATGGAT
+AGAAGAGGAGATGGTTTGTCGAAAGCATTGCAAATTGAGTGTAAATCGGAGAGGGAAATT
+GTCCCTATGGGCATGTTGAAGGTTTTGAATAAGATCGAGGCATTCCACGGCGAAAAAACT
+GCATCTAAGGCGTATAAATGACGAAAAATCAAGACTGCATGACACTGCCAGTGCGCTGGG
+AGCAGGCTCCCGCGCGGGAAGATTTCTGGCAAGAGTTGAGAACCGCATCACGTTGGCTGC
+TTTTGCTGGACTATGACGGCACACTGGCGCCGTTTCATCAGGATCGGATGAAAGCTACGC
+CCTATGCGGGGGTGAAGGAGCGGCTGGAGCAGTTGCTGAAGATTGAGAAGGGCCGGATCG
+TGGTGATCAGCGGGCGGCAGATTGAAGATCTGAAGCAGCTGTTGCAACTGAGCCAGCCAG
+TGGAGATCTGGGGATCGCATGGGCGGGAACATCTGCTGCATGACGGCTCGTACCGCCTGG
+TGGATTTGACCGAAGATGAGCGGCGCGTAGTGGAAGCAGTGACAGCGCGGATGAGCGAGC
+GTGGATGGGCCGGGCAACTGGAGCGGAAGCCGACGGCGATCGCCGTTCACTGGCGGGGAT
+TGCCAGTGAGCGAGCAGAAAGAGCTGCGCGAGGCCGCAGAGCAGTATTTTGCCGAGGCGA
+ATCCGCCCGATACGCTGGAGATGATGCCGTTTGAGTCCGGCGTGGAGCTGAGGTCGCGTT
+CTCGGACCAAGGGACAGGTGGTGGCCGAGGTTCTAGCCGAGGAGCCCGCGGATATTCCGA
+CAGCCTTTCTGGGAGATGACTGGACAGATGAGGATGGATTCGCGGAGCTTCGCGGACGCG
+GTGTGGGCATCCTAGTGCGTCCTGAGGCGCGCGAGTCGTGTGCCGACTATCATTTGACGC
+CGCCGGAAGAGTTGCTGGAATTTCTAGACCGGTGGCTGGAAAACGCGAAAGAGAGCATTC
+GATGAGTGAAAACCAGGTCATTATTGTTTCCAACCGGCTTCCGCTGTCGATGACGGTGAA
+GTTTGGATCGCTGAAGGTGGGAAGAAGCAGTGGAGGATTGGTGACGGCATTGCAGCCGAT
+CCTGAAGAGCCGGGGAGGGACGTGGATCGGAAACGGCGGGACGCGCGAAGACAAGAGGAT
+GGCGCGCGCGCTGGAGGAAGAGGCCCGGCGGAGTGGGTTTGATTGTGTTCCGGTATTCGT
+GACCGAGCAGGAAGATCGCAATTTTTACGAAGGTTTTTCTAACCAGGTACTGTGGCCGCT
+CTTCCATGACTTTATCGGCGAGTGCCGGTTTGAGCCGGAGTACTGGGACTTTTACCGCAA
+GGTGAATGGCAAGTTTGCAGATGCGGTCATGAGGGTCTACAACGGCAAGCAGATCCTGTG
+GGTGCATGACTACCAGTTGATGCACGTGGCGGCCAGTTTGCGGGAGCGGGGATGCAAGGG
+GCGCGTTGCATTCTTTCTGCATACTCCATTTCCTTCCTACGATGTATTTGCGAAGTTGCC
+GTGGCGGCGCCATCTGCTGCTGGCTATGCTGGAGTACGACCTGATCGGGTTGCAGACCGA
+GCGCGACGTGCGGAATCTGGTGAGCTGCCTGCGGCGGCTGGTGCCGGAGGCCTCGATGTC
+GACGGATCATGGCGTGCATCGGGTGTCATGGCACGGGCGCACGGTTGTGATTCAGGACTT
+TCCGATTTCGATTGATTTCGATGAGTTTGCGCGAGCGGCCAACCAGCCGGCGGTTGAAGA
+GCGGATGCGCACGATTCTGGCACGTATGGGCATGGGACAGGTGATTTTCGGGGTAGACCG
+GCAGGACTACACGAAGGGAATTCCACACCGGCTGAGAGCCTATGGTGAGCTGTTGCGGCG
+CAGGCCTGAGATGGTCGGCAAGGTGAAGCTGGTGCAGATTGTGGTGCCCAGCCGGCAGAA
+TATTCCCGGATATGAGGCGCTGAAGTCTCGAATCGAGCACCTGGTGGCGAGCATCAATGG
+CGAATACACGCAGCCGGGTTGGGTGCCGATCCATTACATTCACCGGGCGATTCCGCGCGA
+GGAACTGCTGGCGCTGTACCGAGCCGCGCATGTGGGGCTGGTGACACCGCTGAAGGACGG
+GATGAACCTGGTGGCCAAGGAGTTCTGTGCTTCGCGGATTGACGACCGAGGTGTGCTGGT
+GCTGAGTGAATTTGCCGGTGCGGCGGCGGAGATGTACCGCGGCGCTCTGCTGGTGAATCC
+CTTTGATCTGGAAGGCGTGGCCGATGCTCTGGAACAGGCGCTGCAAATGCCAGGCGCCCA
+GCAGCAGGAGAGGATGCGCAAACTTCGCCGTTTCCTGAAGCATGCCAATGTGCATCGCTG
+GGTGGAGGATTTTATGGAGGAGATTGAATCGGTCAAAGCGCCACGCTCGCGGCGGGGATG
+ATTAGTGGGGACGCGACTCAGGATGGGTAATTTCCGAGGAATACGAAAAGAGGCTGCCTT
+AAAGGCCGCCTCTTTTTCGTGCAGGAAAACTGATTAGGGAAAACCTTAGTTGTAGGAGGC
+GATGGCCGAGGCCTCATCGTCCTTGATGTCGAAGACGGTATAAAGCTTGGTGATCTGGAG
+CACGTCATGAACGCGCTTGGTGAGATTCAGGAGCTTAAGGTCGCCGCCCTGGTTGCGCAC
+CGCAGTCAGAGCGCTGGCCATTTCGCCTATGCCCGAGCTGTCGATATAGGTCACATCCCC
+AAGGTTGAGGAGAATCTTCTTCTGGCCCTTTGCCAGGAGATCACGGACTGCGTCACGGAG
+CTGAACGCTGCCTTCGCCAAGAAGAATTCGGCCGCTAAGGTCGAGAATTGTCACACCGTC
+CACCTGACGGGTTGTCACTTTCATGCTCATAAAGAGTTTCCTCCCTGGAGACTCTGTTTG
+GCTGTCCCCAAATGTTTAACGAGTGTAAGCTCCGTTCCGGGATGCAGTTGTTTGAAGTGT
+ACTTCATCCATGAACGAACGGATGAGAAAGATACCGCGGCCGGATCCACTCAGCAGATTC
+TCAGGCTTGAGGGGATCGGGCAGGGCGGCAGGATCTAAACCTTCGCCCTGATCCATGATG
+TGGATGATGAGATCGGAGCCATTGTTCTCAAAGGTGACCGTAATGCGCTTGTCAGGGGCA
+TAAGCATTGCCGTGGAGAACAGCGTTGACGGCGGCTTCGCGCACGGCCATGCTGACTCGA
+AAGGCTTCGTCCTCATCAATACCTGCGTTGCGGGCCATCTGTTCGGCGGTTTGTTCGACT
+TTGTCAACGCTGTCGAGCGAGGATGCAAGCGTGTATGTGACGCGGGTTTCCTGTTGTCCC
+CTCAAAAAGCTCTCCCTCGCATGGCGTTTGTGGCTTTGGTCTTGTCGGCAGTTTGCTTGC
+TGGTGTGGCTGATGTCAAGCAATCCAGTCCCGACGAGCCGTCCAACCATTTACGGAAACC
+AATATACCTGAGATGAGGCACGACGTGCGCGAAGACTGCGATGGCCTCTGGCCCAGGGCC
+GTGATGCTGCTATTGAGTGATGACCACGGCTGGGACAGGGGAGCGGATTCTGATAGGGAG
+CGGGCGGAATGCCTGTTAGACTCATGCCGATGCCAGAGGTGGATGCCAAGGTAACGCTGA
+CCATGCTGCTCGGCACTCCGGTGACCGACGCCACGGGAAAGCTGCGCGGCAAGGTACGGG
+ACGTGGCCGTGGCCACGGGCGCCGAGGCCGGCCGGGTGGCGGGGCTGGTGGTGAAGAATC
+GCGACGGGCTGCAGGTGGTGACGTCGGTGGATTTGCGGCGGACGCCGAGCGGAACCCTGG
+AGTTGCGAGCCGATGCGCAGATGCGGCCGTTGACCGGGGAAGAAAGCTTTCTGCTGCTGC
+GGCAGGATCTGCTGGACCGGCAGATTATCGACGTGCACGGGCGCAAGGTGGTGCGCGTGA
+ATGACGTGGAACTGGACTGGTGGAACCAGGAGCGGGGCGCGGCCGGGCAGCAGGAATCGT
+TGCGGGTAACCGGAGTAGCGGTGGGCTTGCGGGGCGCGTTGCGGCGGCTGCTGCTGGGGC
+TGATGCCGCAGGCGACACTCGACCGGCTGGCGCGGAAGGTGCCGCAGCGGAGCATTCCCT
+GGGAGTTTGTCGACATAGTAGAGGTGGACCCGGCGCGGCGGGTGAAGCTGAAGATTGAGC
+ATGAGCGGCTGGCGCGGCTGCATCCTTCTGACATTGCCGACATTCTGGAAGATCTGGCTC
+CGGCCGAGCGCGAGGCGCTGTTGCGGAGCCTGAGCGAGGAGTTGGCCGCCGATGCGCTGG
+AGGAGTTGGATCCGAAGTTGTGGCGGTCGCTGCTGCAGTCGATGGATTCGGAGACGGCAG
+CCGGGATCGTGGAGGAAATGGATCCTTCGGCGGCGGCCGATCTGCTGGCGGATTTGAGCA
+AGGCGGATTCGGAAGCGATTCTGGGCGAGATGGATCCGGAAGAGCGGCAGGAAGTGAAGG
+AGCTGCTCGAGTTTCGGGAGGACTCGGCGGCAGGCCGCATGACGACCGAGTATGTTGCCG
+TGCCGGAGGACGCGACGGTGGCTGACTGCGTTGCGGCGCTGCGGGAGTTTGAAGGGGATC
+CGGAGACGATCACCGAGATTTATCTGCTGGGCGAAGACGATTTGCTGGTGGGCGTGGTTC
+CGCTGGCGCGGCTGGTACTGGCGCGCGAGGAGACGCGGGCGCAGGTGCTGAGCGAGCCGG
+AGACGATTACCTGCGAGCTGGAAGCGCATCAGAACGAGGTGGCCGAGCTGTTCGACAAAT
+ACAATCTGCGGGCGCTGCCGGTGGTGGATGAGCAGCGGCGGCTGGCGGGCGTGGTGGAGG
+CCGACCACGTGATTGCGTTTCTGCGCGAGCGGCGCTGATGGCGCGTGATATGTTCGCTGA
+GGGAGCTTAAGGCTTTTAGGCCCTCTCTGAATTCAACTGACAGACAAGTGATGAGTCGAC
+CCGATGCTGAAGCGCTGGCGAACCCGGATTCTTTTGTTCCTTGCGGTGCTGGGGCCGGGG
+ATCATCACGGCCAACGTCGATAACGATCCGAGCGGAATTTTTGTCTATTCGCAGGCGGGA
+GCCAAGTTTGGCTACGAGCTGCTGTGGACGATTTTGCCGGTGACGCTGGCGCTGATCGTG
+ATTCAGGAAATGTGCGCCCGCATGGGGGTGGTGACCGGCAAGGGGTTGAGCGACCTGATC
+CGCGAGGAGTTCGGGCTGCGCATCACCTTTGTGATGATGGTGCTGCTGGTGGTGGTGAAC
+TTTGGCAACGTGATTGGCGAGTTTGCCGGAATTGCGGGCAGCCTGGAGCTGTTCCACATG
+ACGAAGTACGCCTCGGTGCCGGTGTGCGCGCTGCTGGTGTGGCTGCTGGCGGTCAAGGGC
+GATTACAAGCGGGTGGAAAAGATCTTTCTGGTGGGATCGGTTTTCTACATTGCTTATGTG
+GCGACGGGCGTGCTGGCCGCGCCCAACTGGCACCTGTCCATACTGAAGACGGTGACGCTG
+CCGCACCGCTCGGTGTGGCGGCAGGACGGCTACCTGTTCATGGTGATCAGCATCATCGGC
+ACGACGATTGCGCCGTGGATGCAGTTCTATCTGCAGTCGTCGGTGGTGGAGAAGGGCATT
+CGAGTGCAGGACTACGCGGCTTCGCGGGCCGACGTGGTGGTGGGCTCGTTCTTTACCGAC
+GTGGTGGCGTGGTTCATTATTGTGGCCTGCGCGGGAACGCTGTGGGTGCATGGGCTGGGC
+AAGATCAACCTGCCTTCGGACGCGGCGGTGGCGATGCGGCCGCTGGCGGGCAATTACGCA
+TTTCTGCTGTTTGCACTGGGGCTGTTTAACGCGGGATTTTTTGCCGCCTCGGTGCTGCCG
+ATTTCCACCGCCTACACGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
+NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN
+NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCCTCGGGGCTGCCGATTTCAACCGCCT
+ACACGGTGTGCGAGGGGCTGGGGTTTGAGTCGGGCGTGGACAAGAAGTTCAGTGAGGCTC
+CGTTTTTCTACTGGCTTTACACGCTGCTGATTGTGGGTGGCGCGGCGGTGGTACTGATTC
+CTCATTTCCCGATCATTGAGTTTTCGATCTTTTCGCAGATGCTGAACGGGATTCTGTTGC
+CGATTGTGGTGGTGTTCATGCTGCTGCTGATTAACCGCAAGGACTTGATGGGCGAGTATA
+CGAACTCGCGCTGGTTCAATGCCGTGGCGTGGGTGACGGCGGTGGTGGTGACAGTGCTCT
+CCGTGGTGCTGATGGTGCAGTCAATCCGGCAGGTGTGAGGACTGGCCGTCCAGGCAGCTT
+CTAGCTCTTAGCCTCTAGCTGTTAGCTGTTCATGCGGTTCGCTGGATGTTTGCGTTGATG
+GAGAAGGCGGCCTTGGGATCGATGGGGTCGGGGATGGGTTGGTCGATGGCTTTGCGTGCG
+AGTTCGAGGGCATGGGCGCGGGACTGGCAGGCTTTCCAGCCGGTTTTGATCCAGTTCTGG
+AGTTCGGATTTGTCGGCGGGAGGGCCGGCGACGGGCGGACGGAGGGTTGAAGGCGGTTCT
+TGGCCCTGGGTGAGGTAGGCGTCGAGGGTGGCTTCATACGTGAGCCGGTTGGAGAGATGA
+CGGAGGGCCAGTAATCCCGAGTCCATGAGGGGATGCTGGGGCTGCTTTTCGGCGTGGAAC
+TGCTCGGGACCGAGGGTGTCTCCGTTGTCGTACTGGACGTAGGTTTCGACGGTATTGACG
+GGGGCGAAGTCCTTTTGCTTGACGTTGCTGGCGGCGAGGCGGAGGCCGTAGAGGTAGGTG
+CGGGCTTCGGCAGAGGTGATTTTGCCCTGGGCGAGCGCGGTGAGGACGCGGCCGATGGCG
+ATCTGGATGGAGGCGAGGTCTTCGAGGAGCGGGATTTCAATGCCGTTTTTGGGCGGCGGC
+GGGGGAGGGTCCTCGGAGCGTTTGGCTGTGCCGTTGGGCGTGCGGTGATGGAGGTGGAAG
+AAACAGTAGTCCTCTTTCCAGACGCGGTGGGCNCGGCATTGGACTCCGTTGGCGCGGACG
+TGGCGGCATTGGTTGGGCATGGATGGCTCCTTGTTTTGGGTCGGCGCTTTGCGCCGATGC
+AGTCCCACACTTTCTCCTCGAACAGCGCGAGGAGAAAGTATGGGGCACCCGGATTTTTCC
+GTTCGATTAGTACTTTGTAAGTGATTGATTCGGGGAGGGTTGCGGGAGGATTAGTCTCGT
+AAGTGCTGCGGAATCAGTAAGTTATGTTTTGAGTGTTGCGGACAGCAAAAAGGCCCAGAA
+AAAGACCGCTGGTGCGGTCCTTTTCTGAGCCTCTATTTATAGGGTAGCAATTTGAGGGTG
+AATTCCCGGCAAGAAAGTTGGCCGGTACTGGCCGCGGAACGGCTGCGGGGCCCCGTCACT
+TGGCATCCTTCATGATCTGAAATAGTGAAGTAAAAGCTTCACTATTTATACTGGGTGCTA
+TATGGTGAAGTTTATACTTCAGTTTTTAGAGGAGATTCGAAATGGAGAAACCGACGGTGA
+TTCACAGCAGTTTTACCCTGGAGCGCAGTTATCCGTACCCGGCGGAGAAGGTGTTTGCGG
+CTTTGGCCGATCCGGAGAAGAAGCGGCGGTGGTTTGCCGATTCTCCGAACCATGAGGTGG
+TGAAGTTTGCAATGGATTTCCGTGAGGGCGGCGCGGAAAGGATGGAGTACCGATTTAACG
+AGGGGACGCCGTTTCCGGGCGTGATGCTGGTGAACTCCGGACACTACGAAGATATTGTTC
+CGGGGCGGCGTGTGGTGCTGTGTTCAACGATGACGATTGCGGGGCGGAAGATTTCGGTTT
+CGCTGGTGACGTTTGACCTGCTGCCGCAGGGGGAAGGCTCGGCGCTGTTGTGCACGTTCC
+AGGGAGTGTTCTTTGAGGGCGCGGATGGACCGGAGATGCGGAAGGCTGGATGGGAGTTTC
+TGGTGGAGCGCCTGGGCGAGGAAGTGGCACGAGAGGGCTGAGACGCATGAGGAAGCGGAA
+GCCGAAGGTGGACCGGATTTTTCATGCACTGGGCGACCCGATGCGAAGGGTGATGGTGGA
+GCTGCTGCGGAAGAGGCCGTACTCCGTTTCAGCTCTGGCGGAGCCTTTGGGTATTACGCT
+GACGGCGGTGGGGCAGCACCTGAAAATTCTGGAGGAAGCCGGGCTGGTGCGGACGGAGAA
+GCTGGGGAGAGTTCGGACGGTTCAGCTGGAGCCGGAGGGTTTTGCCGTGCTGGAAGCCTG
+GGCGGCAGAACACAAGGGAGAGTGGGCGCTTCGACTGGACAGGCTGGGAGATGTGCTGGC
+GGATGACGGGTAGCGCAGAAACGGGAAGGGGAGATTTCAATCGTTTGGGGGCTGAAGTTG
+CGTTGTTGACGCTGTCCGAAATGGGAGCCCTTTTCCCGGTTGGCCTGGGCTGTTCTCAGA
+GTTCCTTGATGAGATTGATGACCGGCGCATAGTGAGCTGCTACCAGCAGCATGAATCCGG
+CCATAATTACAGAGCACCAAATAGTTGCCCAGTACATGACTTTGTCATTGGTTCGAGTGA
+TCGTGCGCATTTGCAGCCATATGCGCCCGGTCAAGGCTCCCACCAGCGCGGTGCCAAGAA
+AGATTGCGGCAATGAGTACGAAAGGCCAATTCGCTCTAAATGTGTTCGCGGTGGTCACAA
+GTTTTCTCCTCGGGTATCAGCAATTGTGTCCAGGCGTCACAGCTTTTGCGACTTCCTCCG
+AATTTAACTCTCGTTGCCCCTTTTGTCATCCGTGCGGAATGCCTTCCGGCTAAAGCAAGC
+CGGAAGGCATTCTGCTTGTTCCGGCGTCAGCGCTGGGCGATGGCGTCGAGCAGGTCAAAG
+AATTCAGGGAAGGAAATGGAGGCGCATTCGGCGCCGCGGATGAGGGTTTCTCCTTCGGCG
+CGAAGCGCGGCCACGGAGAAAGCCATGGCGATGCGATGGTCGCCGCCGGAATCGATTTCC
+GCGCCGTGGAGGGTCTGGCCGCCAGGGACATCGAGGCCGTCTTCGAACTCCTCGACTTCA
+GCGCCCATGGCGCGAAGATTTTTGACGACGAGGTCGATGCGGTCCGATTCCTTGACGCGC
+AGCTCGCGGGCGTCGCGGATGCGAATGCCGTTGTTGGTGTAGGGGCCGATGGCGGCGAGG
+ACGGGCAGCTCGTCGATGAGCTGGGCGGCGAGCGCGCCGGAGACGGTGGTTCCGGTGAGG
+CCGTCCGGCGGGGCGTTGACTTTGACGGTGCCGATGAGCTCGGAGGCCTTGTCCTCAAGG
+TCGATGACGCCGATGTGGGCGCCGAGAGCGGTAAGGACGTCGAGCAGCGAGGCGCGGGTG
+GGGTTCATTCCGAGATCGTCAAAGACGAGGTTGGAGCCGGGGAAGAGCGCGGCGGCGCAG
+AGATAAAATGCCGCCGAGGAGATGTCGCCCGGAACCTTGGCTTCGATGGCGGAGAGCTTT
+TGACCTCCGGCGATGGTGATGGAGTCGATGGTGCGTTCGAGTTCGGCACCAAAGGCGCGG
+AGGGCCAGTTCGCTGTGGTCGCGGGTGCGGACGGATTCACGCACGGTGGTGGTTCCGCTG
+GCCTGCAGACCGGCGAAAAGAATGGCGGACTTGACCTGCGCGCTGGGCACGGGCGTGGCG
+TATTCCATGGCTTTGAGCGGGATGCCGTGGATGACCATGGGCGCATGGCCCTCGGTGAGG
+GAAATGTTGGCGCCCATTTGCATCAGCGGCTTGCGGATGCGCTCCATGGGGCGGCGGCTG
+AGGGATTCGTCGCCGACGAGGGTGAATTCGCCTTGCTGGGCGGCGAGGAAGCCGGCGAGC
+ATGCGCATGGTGGAACCAGAGTTTCCGCAGTCGAGCGGGGAGGATGAGGGCTGGAACTGG
+CCGCCAACGCCGGTGACTTCGACCGAGCCGTCCTCGCCGCGGACGACCTTTGCGCCGAGG
+GCTTCGACGCAGGCGAGGCTGCTGGAGGGATCGGCTCCGGTGGAGAAATTGGTGAAGCGG
+CTGGTGCCTTCGGCGAGACCGCTGAGCAGGGCGTAGCGGTGGGAGATGCTCTTATCGCCG
+GGCAGGCGCAGGCTGCCCTCAATGTTGCGCGCGGGCGCAATAGTGCGTTCTGAAACAGAA
+AGATGCAAGATAATCGGCTCCTGTTAACAGGATAAAGCAGGGAGACCAGCCGGTGCTGGC
+CGCACGGGAGAGCCTACGCGTTGCGTGCCAAAAGTCTGCCTAATCCGCGCTTCAGGCTTA
+CTTAGGAGTGGCGCGGGCGTGGCTACGGCAGAGTGGGGAATTGCTGCTACCGGCCGCCTG
+TGGGTAGATGGCAGAAATTTACGGTGGAGCGGGAAACCTCGGGGGGGGGGGGGGAATTTG
+CATCTAAGTGCGCTGGAGTCATCAAGCCGTAAACCTTAAGTGCCATAAGAATCTTTTTCG
+CGGAGGATTGCACTGGTGAATGTGTTGAGAAAGAGCTTTGTGGTGGCGGTGGTGTTGCTG
+AGTTTTGGAGCTTCGGCTGCCGTGGCGCAGACGACGGTCGCGGCCAGCGTGTATGGGGCG
+TTTCGGTCTTCGACGAGGACGGGCGGGATTAGCAATTTCACCGTTGAAAATCCGTCGAAC
+GCGGCGGGATTTCTGCTGGAGCTGCGGCATATTTCGAATCCGCTGATGGGATACGAACTG
+ACGTACTCGTATCATCGGGCGAATGAAGCGTATTCGAACACGTTGAAGGTGCTGTGCCCG
+ATTTCACCGGGAGGGTCTTGCCCAGAGCAGATCACGACGGCTGGGGTTTCGGCGAACGCG
+CAGGAGGTGACGGGAGACTGGGTGGTTTCTTTCCCGTTGGCGAATTTGAAGCCGTTTGTG
+CTGGTAGGCGGTGGGGTGATAGTTACGTCTCCTGCGACTGGCAGTGTAACTGCAACAATT
+ACGGATTTCGATCCGGTGACAAATATGATGTCTCAGACCACCAGCAGCATGCCGACGCAG
+ACGCAGACGAAGGGTGTGTTTCAGTACGGAGCAGGGCTGGACTGGACAGTGCTGCCGCAC
+ATCGGGCTGCGCTTTCAATATCGCGGCAACGTGTACAAGGCTGCGAATCTGACCAAGGTG
+TTTACCTCTACAGACAAGTTCACGCAGACGGCAGAGCCGGTGGTGGGAGTGTTTTTCCGG
+TTCTGACGGAGGTTGCGCGGAGGATTTAGACGACGCGGAGGGCGATGAGGGTTTCGTCGT
+CGAAGCGGTCACAGTCACCCTGAAATTCCTGCAGCTCCTCGAAGACGGCGTTGACGGCTT
+CTTCTGCGGGCAGGTGATGGTGACGGGCAATAGAGTCGGTGAGGCGCTCCTCGAAGCTTT
+CTCCGGCTTCGTTTTCGCCGTCGGTAATGCCGTCGCTGAAGAAGAAAACGGAGTCGCCGG
+GGCGCATGGAAAGGCTGATTTCCTCGTATTCGGCCTGGGGGAACATGCCGAGCGGGAAGC
+CTTCGACGGGGACGGTTTCGATTTCGCCGCTGCGGCAGTAGATGGGCTGGACCGAGCCGG
+CGTTGGCGATCTGGAGGGTGAGGTTCTCGTCGTTCCAGACGGTGTAAAGCATGGCCACGT
+ACTGGGAGTCGAGGCGGCGCTCGTGGAGCGAGGCGTTGAGAGCCTGCAGCATGGCCGCGG
+GTGAGGGTTTCAGGCTGGCCTGGGAGCGCATGGTTCCGCTGACGACAGCGCCGTAAAGGG
+CGGCGGCGGCGCCTTTGCCACTGACGTCGCCGATGGCGAGCGCGCCGCGCTGATCGTCGT
+AGTTGAGATAGTCGTAGAGGTCGCCGCCGATGGTGCGCGCGGGCAGGAAGCGGGCGGCGA
+ATTCGGCGTGGGGGCGGCTGGGCAACGAAGGCGGCAGCAGGCGGAGCTGGACTTCGCGGG
+CCATTTGCAGGTCGTGGTCAAGACGCTGTTCCTGCTGGATGACACGCTGATAGAGCTGGG
+CGTTCTCAATGGCGATGGCGATTTGCGCGGCCAGGGTGGTGAGCGCACGGACGTGATCCT
+CGCTGAAGTAATGGGGTTGGGTGTGTTCGACGTCGAGGACGCCGACGACCTTGCTCTTGT
+ACATGAGCGGGACGGCCAGCTCGGAGCGGGTTTCTTCGTTGACCTTGTGGTAGCGGGGAT
+CGCGGCGAACATCGGGGATGTTCATGGGGCGGCGCTCGGCAATGGCGGCGCCGACAATGC
+CGCGTTCGACGGGGATGGTTTCGTTGGGATAGTAGCGTTCGCCAAAGCGAAGCGCGAAAC
+GGTTTTCGAGCACGTGCTCGATGGGGCGGACGGTCCAGATGGTGAACATCTGGTAGTCAA
+AGAGACGCCGCAAGAGCTGGCTGATGCGCTCGAAGAGACGATCGGTGTCGAGGATGGAGC
+TGAGGTCGCGGCTGATTTCGTTCAGGACTTCAAGGGTTTGCGCCTGGCGGGAGACGCGGG
+TGTAGAGGCGCGCGTTATCAATGGCGTGGGCGATGCGCGACGCGGTGAGAGTGAGCAGGT
+GGAGGTGGTCTGGCTGGAAGTAGTTGGGCTGCTCGGACTGAATGTCGATGACGCCGATGA
+CGCGATTCTTGACGATGAGCGGAATGGCGATCTCGGAGTGAACGTCGGGGTTGGCGTTGA
+TGTAGTTTTCGACGTCACGGACGTCGGGGATGAGCATGGGCTTGCGCGTGAGTGCCACCT
+GGCCGGTAACGCCCTGGCCGAGGCGAATGCGCATACGCTCGACCTCGGGCCGGTGGCCGG
+TCTGGAAGCGCATGCGAAGGTCGTTGGTGCGGTTATCGAGCAGAAGGATGGCGAAGATGC
+GGTAATCGATCACCGTGCGGACAAGGTCGGCGGTGCGCTGCAGCAACGTCTGGAGATTGA
+GCGTGGTATTGAGGGCGTCGGTGAGCCGCAGAAGGAAGTCAGTCTGGGCCAGCTCGACGG
+AGCGCGAACCTGCAGCCGCAGCCGCATCCGTGGGGTGGCTGCCCTCAATGGACGAAGAGT
+GCTGTTCCGGGGTGGTCTGGGGGCGCGATTCGTACACGGTTCTCCTGTTGAACTGCCATG
+ATAGAGCATCTTCGAGGCTTCTGTAGAGTGACCGGGGATAGCCCTCCCTGGACGCGGATC
+AAGGGAAGGGCCACATTTATTTTGGAACAGCTGGGTTTGCCGCTGGAATTTTTCTGAATG
+CTTTGTTCCCGTGGCGATAAAAGCTCTGTCCCCCACGGCGCAAAGTTGCCACAAAAAAGA
+CTGGCCGCTGCAGGGGTCAGGATGCGGGGATGGAATCGAGGATGCGGATATCGGGGAGAT
+TGCGGTAGCGTTCAGCGTAGTCCATGCCATAGCCGACGACAAACTCATTGGGGATGCTGA
+ACCCGATGTAATGGCCCTGAATGGGACGGATGCGGCGCGAAGGCTTGTCGAGCAGGGCCG
+CGACGCGAATGGAGCGCGGGTTGTGCCGTTCAAAGTGGCTTTGCAGAAAGCTGAGCGTGA
+CGCCGGTGTCGAGGATGTCTTCGACGACGATGATGTGACGGCCTTCGATTGGTTCGGTGA
+GGTCTTTGATGAGTTGGACGGCGCCGCTGGAACGGGTTCCGGACTTGTAGCTGGAGACGG
+CGACGAAATCAAAGGTGCAGTCGAGGTTGATGGCGCGGGCCAGGTCGGCCAGAAAGATGG
+CCGCGCCCTTGAGGACGCCAACCAGCACGACGCTTTCGCCATGGAGGTCTTCGCGGATGT
+GGCGGCCCATTTCCCGGACGCGGGACTGGATCTGATCGCGAGTGAAGCGAATGCGAAGAC
+TCTCGGCGGGCGGGAATTGGGTTTGATCGGGCATGATGTTCGAACTCAGGTTTCCAGATT
+ATCGCGAAAAGCATGAGGAAAAAGCTGTGGTGGCCAAAGATCGGTGATGCCATTGAGCGT
+TTCGTGCGTCCAATACGAAGACAGCTGTCGTTACTATCTATGTATCCATTTATTCATATT
+GGTCATTTCACTATCCCCACATACGGCATCATGATGTGGCTCGCCGCCGTGGCTGGATGC
+ATCGTCCTTTACAGGAACTTCAAGCGCTGGAAGGTGGAAGGCGATGCCATCACCATTGTG
+GCGTTTGCGACGGTGATCGGCATTATCGGCGGAAAACTCTATCACGTGCTGGAAAAGCCG
+GTGCTGCTGATGCACCATCCCGCGCTGTTGATCAGCCGGTCCGGATTTGCCTGGTACGGC
+GGGATGATTGCGGGGATTCTGGCGCTGTTGTTTCAGGCCGGAACCTATAACATTCGTCCC
+CTGCGGATGCTGGACCTGTGCGTGCCCTCGGCGGCGCTGGGTTACGGGATCGGGCGGCTG
+GGATGTTTCTTTTCCGGCGATGGCGGCTATGGTCCCCCGACCAAGATGTGGTTTGGCATG
+AGTTTCCCACATGGGACCGTGCCCACGACACAGAAGGTGTATCCGACGCCGCTGTTTGAA
+TTTGTCGCCGCGGTCATTATTTTCTATATTTTGTGGCGGCGCAGCCGTCCAGCAGCGGAG
+CGGAAACTGGGGCACATGACGGCGGAATACCTGCTGTTGGCCGGCGGAGCGCGCTTCCTG
+TTCGAATTTATTCGCATCAATCCGAAGATCTTTCTTGGGTTGTCGAATGCGCAGTGGGCG
+AGCATCGCGGAAATGCTGGGTGGAACCGCCCTGCTGTGGTGGTCACGCAAGTATGCTTCG
+ACTCCGCAACCCGGACAGCAGGGAAGGCAGCCGAAAGAAGAGCCGGCGCTGGTTGCCGCA
+GGAGATTCCGGTGGGCCGCCTACAGCGGAACAGACTCAATAAATCGTGGAAAAACGACAG
+ATTTTATTCAGGAAACAGCTCTTCCCAATGGAGGGGCTGTTTTTTGCGTGAAAGCGTTCA
+GGGCAGACTGCGCTGGAGGCTGGAAACGGATCTGTCGTGGTGGAGTTAGAGCGGAAAAAG
+TGCATGGGGGCGAAAAGCGAGAGACGGAGAATTTGCGAGCGTAGGAGCAGCGTTTTCGTC
+TATATACTCTAGATTACGGTTTTCCATGTATCCATTTATCCATGTTGGTCCCTTAACGAT
+TGGCACATACGGCATCATGATGTGGCTTGCCGCGGTGATCGGGTGCTACCTCCTTCACAA
+GAACTTCAAGCGCTGGAAGATTGATGCCGATGCGATCAGCATCATCGCCTTTGCGACGGT
+GGCTGGAGTGGTGGGCGCAAAGCTCTACCATGTGCTGGAAAAGCCAGTGCTGCTGATGCA
+TCATCCAGCGCTGCTGATCAGCCGGGCCGGGTTTGCCTGGTTTGGCGGGATGATTGCCGG
+GATTCTGGCGCTGCTGTTCCAGTCCGGGACCTATAAGATTCGTCCCCTGCGGATGCTGGA
+TTTGTGCGTGCCCTCGGCGGCGCTGGGGTACGGAATCGGGCGCATTGGATGCCAGCTGGC
+CGGAGACGGGGATTACGGCATTCCGACGAAGATGTGGTTCGGGATGAGCTATCCGCACGG
+AATTGTGCCGACAACACAGAAAGTGTATCCGACGCCGATTTTTGAGTTTATCGGGGCCTG
+CATTATCTTCTATATCCTCTGGCGGCGGAGCCGGCCGGGGACGCCGCGGAAGCTGGGACA
+GATGACGGCCGAGTATCTGCTGTGGACCGGCGGGGCTCGCTTCCTGGTGGAGTTTATTCG
+CCGGAATCCGAAGATCTTTCTGGGCCTGACCAATGCGCAGTGGGCGAGCATCGGGTCGAT
+GGGAGCACGCCGACACCGCCCGCCTGGCCAGGAAGCTGGTGCGGCTGGCCCAGGACGCGC
+CGGTCAGCTTCGATCCCGACACCTTCAAGGTAACCCCTCCCGACCCAGCCGTGATCACCC
+CGGTACTGGCCCAACTGGAGTTCAACCAACTGCTCAACCAGTTCGCAGCCCCACCACCCA
+AGGCCGACTACCGCCGCCTCAGCGACCCGGAGGAGATCGAAGACTTCCTGAAGCCCGTGG
+CCCGGAAGAAACGCTTGGCCATCGACACCGAGACCACCTCCATACAGCCCATGCTGGCCG
+AGTTGGTGGGCGTCTCCCTCTGCCATCAGGCGGGCGAGGCGGTCTACATCCCCGTGGCTC
+ACAACCTGACCCCCGGCCAGAGCCAGGCCGACAAAGAAGCCGTGCTCCAGACCCTGGCCC
+CGGTGCTGGCCGATCCGGCCGTCACCAAGATCGGCCAGAACATCAAGTACGACCTCATCG
+TGCTGGGCCGCTGCGGAATGGAGATCAACGGGCCGCTCTTCGATACCATGGTGGCCAGTT
+ACCTCTTGAACCCCGGCAAGACCAGTCACAACTTGGCCTCCATCGCCGCCGAGTTCCTGG
+GCCGCTCGGTCATCTCCTACCAGGAGGCCACCGGCGGCAAGAACCGCCCCTTCGCCGACA
+CCGACCTGGACCAGGCCACCGACTACGCCGCCGAAGACGCCGACGTGGCCTGGCAGGCCG
+CCCAGGTGCTGGAGAAGAAGCTGGCCGAAAGCCACCTGGACGGGCTTTTCCGCGACCTGG
+AGATGCCCCTGGTGCCGGTGCTGGCCCGCATGGAGCGAAACGGCGTGGGCCTGGACGTGC
+AGGGCCTGGAGGATCTGGGCAAGGAGCTGGCCGCCAAGCTGGATGAGATCGAGCGTACCT
+GCTACCGCCTGGCCGGACACGAGTTCAACCTCAACTCGCCCAAGCAACTGGCCCAGGTGC
+TCTTCGAGGAGCTGGGGCTCACCCCGGTCAAGAAGACCAAGAAGGGCAAGACCTCCTCCA
+CCGACGTCTCAGTGCTCACCGTCCTGGCCGCCAAGCACCCCCTGCCGGCCGAGGTGCTCA
+ACTACCGCACCCTGAGCAAGCTCAAGTCGACCTACATCGACACCCTGCCCAAGCTGGTGA
+ACCCCCAGACCGGCCGCCTGCACACCTCCTTCAACCAGGCCGTCACCGCCACCGGCCGCC
+TCTCCTCCAGCGACCCCAACCTCCAGAACATCCCCGTGCGCAGCGAGATCGGCGAACGCA
+TCCGCGCCTGCTTCATCGCCGAGAAAGGCAATCTCCTGGTCAGCGCCGACTATTCCCAGA
+TCGAGCTCAGGGTCCTGGCCCACCTGAGCCGCGACCCGCTTCTAGTGGAGGACCTCACCA
+AGGGCCTGGACGTGCACACCCAGACCGCCGCCCGGCTTTTCGACGTCATGCCCGAGCTGG
+TCACCAAACCCATGCGCGCCCGCGCCAAGACCGTGAACTTCGGCATCCTCTACGGCATGA
+GCGCCTTCCGCCTGGCCCGCGAACAGGGTATCAGCCGCAAGGAGGCCCAGCAGATCATCG
+ACAAGTACCTGGGACGCTACCAGGGCGTGGCCCGTTTCCAGGAGGAGAACCTCCGCCAGG
+CCCGCGAGAAGGGCTACGTCACCACCCTGCTGGGCCGCCGCCGCTACCTGCCTGCCATCA
+ACGCCGGCGACCGCCTGGCCCGCCAGGCCGCCGAACGCATGGCCCTGAACACCCCCATCC
+AGGGCACCGCCGCCGACATCATCAAGCTGGCCATGCTCGCCGCCCACCGCCTCCTGGAAG
+AACGCTTCCCCCAGGCCCTCATGATCCTTCAAATCCACGACGAGCTGCTCTTCGAGGTCC
+CCGCCTCCCAGGCCGAGGACCTGGCCCAGGCGGTCAAGCAGGCCATGGAGGGCGTCATCG
+AACTCGCCGTGCCCCTGGTGGTGGATATCGGCATCGGCCCCGACTGGGCCCAAGCCCACT
+AGGCTAGGCCTAGAGCAATATTTAGAACGGGCGATCTTCTGACTGGGGCAGCGTTTTTTA
+GGGGTATCGCCGGATGTCGCGCGCCACGCGCCACGGTGTCCCCCGCTAGGCGGGGGGCAG
+TGGGGGGAACGGGCGCTCTTCTGTTTGGGGTTACGCTTTTTAAGTGTATCGCCGGATGTC
+GCGCACCACGCGGGGCGTCGACCCGAAGGGAGCCTATGACCTTACGGCGAGGAGAAACCG
+CGCCAGCGATTTCATCCAGGTTTCTTTGAAGGGGACGGGGACACCGCTACTGGGGCGGGT
+TCTTTCCGAGCTAGACCTCAAAGGCCCATCCCCGGCCAGACACCGTCCCGCATCCCTCTA
+TTGCTCCAGGCCTAGCCTGGCGGGGAACACTTTCTTTTTTAAAAGAAAGTGTTCCCCGGC
+GGTG
+>NODE_8_length_21143_cov_115.55_ID_15
+AGACTATAGAATACTCAAGCTTGCATGCCTGCAGGTCGACTCTAGAGGATCCCACCAGGA
+AACAGCCTAGGAACACGGACTCACGGCCTGTTTGCCATCGGGCGAGACCATGTAAACAGT
+CCCAGCCAGTCGACAAGAGGTCCCATTGAGTGGGTTGTAGCAGACACCGAACGGCTGCCA
+GTCGGCAGGATCCATGTCGTTGAAGAAGAGTTGCTCGTCGGTAGCGCCCCACTGGACCTG
+CGCGCCGAGCTGGGTGTCCCAGCCCCGGCTTTCCCAAATGACTTGGCTCTTGCCGGTGTG
+CAGATCGACCAGAACCACTTCTGCCGCTTCGCCGGGCTCCGGCAGGCGTTCCGGCTGGTA
+ACGGGTGACAGCCAGGTAGCGCCCCGAAGGACTGAGCGGCGAGGTGTCGAAGAAGCGGTG
+GAACGCGCCGGGACACTGCGGTGTGAGGTCCCAGACAGGGACCTGAGGGTCGTACTCCGT
+GTAACGGGGGAAGTGGCGGTCCAGCAACGCGTGATCCACGGGCATTTCTCCTTGTGCAAT
+CGTGCTCCCATGACCGTAGTGCCGCGATGCAACCGTGCCAAGGGGAATCGCCGCCCGGGA
+CCGGGCAGGGAGCGAGAACTTGCACCTTCAGTGATGCGAAGCGATAGTCCAAATCTCGAT
+TTGATCCCCCAACCAATCGCAGAACTAGGAACATGCCTGTGAAGAACGTCCTTCTCCTCA
+CCCTTGCAATCGGAGCTGCTGCCATGGCTCAGCCATACGAAGGTCTTGTCGGCACCAGTG
+GGCGTGTCCAGGTAAACCGCAATGGCCGACCCGCATTCTCGATCTCAACTGGAGCCTTTG
+CCGATGGCTGGAGAGGTGCGTCTCTGACGCCGGCGAAGGTGGGAGAAACGACGGACGGAG
+TCTGCCTCGGGAAGATCTCCCTACCCGACAAGCTGACCATTGCCTCTGCCCTTCGGGCCA
+CCGCGGCCGGGAAGGCGATGGAACTCCGCTATACACTCACGCCGAAAGCCGATGCCAAGC
+TGAACAGCCTGCATGTGTCCTTCGGACTGCCAGCGTCCTTCCTGAAGGGTGCCTCCTACA
+CCATCGAGGGAGAGACCAAAGAGGTCCCGGCCGTGCTTGGTGCCACTCACCTCCGGGCCG
+GGGACCATGTTCCCAGCGTTCGGTTCACTTGGCCTAACGGCGACTGGCTACAGGTGGATA
+TTCTCTCCAAGACCCCTGTTCTCTTCCAGGACAACCGTCAATGGGGCGACAGCTTCGATC
+TGCGTCTTGGCCCGCAGATGGTCCCGGCCCAGACGCTTCCGGCCAACCAACCGGTCGAGA
+TTGCCATGCGCGTGAGCGCAAAGGACGGCATGAAGCTGGACTTCGACCGGCCGGTCACGA
+TCACGGCCGGCAAAGACTGGGTGCCACTGGATCTGGAGCTGGACATCGAGCCGGGATCGG
+CTCTGGACTTCTCCGGCCTGGGACAGTTCGACGCGCCGTCCGGCAAGCACGGCTGGCTGC
+AGGCGACGCCCGACGGCAAGTTCGCCTTTGCCGACAGCCTGGACACGCCGCGCCGGTTCT
+ACGGGGTCAACCTCTGTTTCACCGCGCAATACCTCTCGCACGACGAGGCGGAGCGGCTGG
+CCGAGAGGTTCCTGCGCCTCGGCTACAACACCGTCCGGTTCCACCACCACGAGTACCCGC
+TGATCGACCGCAAGAACGGCTGTTCCACCGACCTCAAGCCCGAATCCATTGACCAGCTCG
+ACTACCTCTTCGCCCAGTTCAAGAAGCGGGGCATCTACGTGACGACCGACTGCTACGTCT
+CCCGCCCGGTCTACGCCAGCGAGATCTGGGATGGGGCCAAGGGCAACGTGGAGATGAACG
+AGTTCAAGATGCTCGTTCCGGTCAACGAGCGGGCGTTCGAGAACTGGAAGACCTACAACC
+GCAACTTCCTCACCCATCGCAATCCTTACACGGGCATGCGCTACGCTGACGACCCCACCC
+TCGCCTGGCTGTCGATGATCAACGAGGCCAACTTCGGCAACTACATCCGCAGCGTGTCGG
+ACCGGGCCCGGCCCGACTGGGAGCGGGCTTGGGGCGCGTGGCTGAAGGCACGGTACGGCT
+CTGCCGAAGCCATCACGAAGGCTTGGGGCAGCACCTTTGACGGCGATCTGAGCAAACCGA
+CGGCTAAGCTCGCCAAGTCGTTCACCGACGACAACCGGCAGAGCCGGGACTTCGCGGTCT
+TCCTCGCCGATACCGAGCGGACCATGTTCCTGAAGATGAAGAAGTTCCTGCGCGAGGAGA
+TCGGCACGAAGGCGATGCTCACCAACATGAACGGCTGGACGAACACGCCCCAAAGCCAGC
+TGGCCCGGGCTGAATTCGACTACGTGGACGACCATTTCTACGTGGATCATCCGCAGTTCA
+TCGAGAAGTCCTGGCGGCTGCCCTCCCGTTGTCCGAACACCAGCCCGGTCTTGGCGGGCG
+CTCCCGGCGGGCGTGGCACGGCCTTCAATCGACTGATGAACAAGCCGTTCACGATCAGTG
+AGTACAACTACTCCGGCCCCGGCCGTTACCGTGGCGTCGGCGGCATCCTGACCGGCTGCA
+TGGCCGCGCTCCAGGACTGGTCGGTCGTCTGGCGCTTCGCCTACAGCCATCGCCGTGAGA
+ACGTCTTGAAGCCGAGCACGGCCGGCTACTTCGATATGGCCACGGACCCGCTGAACCAGG
+CCGCCGAGCGCGCCAGCATGTGTCTGTTCCTGCGCGGGGACCTGGATCCCGCTCCCCGAA
+GCGCAGCCATTACCCTCAATCCAGAGACGTTGGAGAAGGGCGACTCGCACCAGGGACGCA
+CGCCACCGAGCTGGGATGAACTCGTCCCGGTCATTCAGGTGGGTACGTTCCTCGGCGACC
+GCCAGAGCAAGGTCCCGGCCGACATTGCCCTGCCTACGACCGATGCCGCACCGGCGGCGG
+CCGACGTGGTCATGCCAAAACCCTACGACTCGGGCAAAGGCTCAGCCATCCTCAAGGAAC
+TGCGCGCGAAAGGATGGCTGGACGCTGCCAACAAGACTGATCTGGACCGCAAGCGCGGGC
+AGAGCGCGAGCGACCAGTTCCTCATGGACGGCGAGAAAGACATGATGGTCCTGGACACGC
+CCCGGACGGCAGGTGGCTACGCCGAGGCGGGCCAGACCATCCATACCCAGGCCGCAGACT
+TCTCGATCCTCGACACGGGAGCAACCGTCTGGATCTCCAGCTTGGACAAGCAGCCGATCA
+CAAGTAGTAAGCGGCTGTTGCTGACCCACCTCACCGACCTGCAGAATACCGAGGTCCGCT
+ATGCGGAACGGGGTCGGAAAACGCTCCTGGCCTGGGGCAAACTGCCGCATCTGGTCCGGG
+TGGGAGAGGCCAAAATCTCCCTGCATCGCAGCGGTGCGAAGCTGCCGAAGGTCTATGTGC
+TGGCCACGAGCGGACACCGCCTCGGCGAGGTCCCCGTGACCAAGGGCAAGAACGGCACGC
+TTGAGCTCGCCATCTCGACCAAGGGCGAAGCGGGTGCCCAACTGATGTACGAACTGGATT
+TCCGGTAGCTCTCTCTCGGAGAGTCGTTGCGCCCCGGCCGACAATGGACCTCGGCCGGGG
+CGTTTTCGTCTGGCACCAACCGGGGCTCAACCAGCAAGCGTTTCCCAGACGAAGGGAAGG
+CGCGGCTGGCTTGCCGGCCACCGTCCTGCCTGCTTGCTTGCCCCTTGGCGGCAACGCTGG
+CGGAGTGTACCTTCTATGGAGAGAAGTTCCCTCGCGCTGCCATGTTCTGGCGGCTCTTGC
+CTTCACGCCGCAGTCAGGGCCCAGATGACCATGCAACGGACTGCCTTCAGCTTGAGCATT
+GCTCTTTCGGCCGTCCTTGCGTCGGCCTTGCTGGTGGGAATTGTGCCTCTGTTGCGAGGC
+GGCGACAACTACGAGCTTGCCGTGAAGTCGGCGCTTCTCGTGCTCGTGGTCGGCTATGCT
+TGGCTGCATTGGCGGGCTGTGACGCGGCGCGGCCGGTGCCTCCTGAAGGCAGCGTTCTGC
+CTCAATGCGCTTGTGCTCGTCCCGCTTGGAGCTACGGCTGCCTTGTGCCATGTGTTCGGC
+GGACCCAAAATCGTGCCACGTGAGGCGGGCGCAATAGGTGGCGCGATCGCGATTCTCGCC
+GCTGCAGCTGCCGCCATGCAGGTCATCCTGCTGACGCGTTGCCGCACGATCGAACTCACT
+GTCCCAAAAGGAGACTGAGCGTGTATTTCAGACAATACAAAGTCGAGGGGTTGGGCTGCT
+ATTCCTACCTGATCGGCTGTCCGGCAGCAGGAACAGCCTGTGTGGTCGATCCGGAACGGC
+ACACCGGGCAATACATCCAGACCGCCGAGCACCAGGGCCTGAGGATTACGCACGTATTCG
+ACACGCACCTGCATGCCGACCACATCACCGGCAGCGCCGAGCTCGCTGCCGCTACGGGGG
+CCACGATCTGCGTCCATCCTGCCATCGGGGCGGAGTACGAGCACGAGGACCTGCTGGACG
+GGCAGCATTACCGGTTCGGCGCGGCTGAACTCGAGGTGGTCGAGACGTTCGGCCATACGC
+CGAACTCCGTCAGTCTAGCGCTGACCGACCATGGCCGGTCCGAGGATGTGTTTGCCCTCC
+TGACCGGAGACCTGCTCTTTGTTGGCGATGTCGGCCGTCCCGACTTGGCGGGCGCAGACC
+TGCTCGAGGAACAGATCCACAACCTATACGAGAGTCTCTACACCAAACTGGGGCGCTTCC
+CCGACTGGACCGAGGTCTATCCCGCCCATGGCGAAGGTTCCCTTTGTGGCAAGGGCATGA
+GTGCCAAGCCCATGACCACTCTCGGCTTCGAACGCCTAAACAACCCGTTGCTTGCTGATC
+TGGAGTTCGCGGAGTTCCACCGCATTATGACCGAGGCGTTCCAGGTGCGCCCCGACAATT
+TCGCGGCCATCGTGGCCAAGAACCAGCGTGGCCCTCAGCTTCTGCGGGAGGCACCCGCTT
+TCATGGAACTGTCCGTGCTGCAAGCGGAGCGCGCCCTGGCCGCAGGGGCACAAATCGTCG
+ACACCCGGGCCCAGAGTGCCTTTGGCGCCGCATTCCTGCCCGGATCACTCAACATCGGAG
+TCAGTCCCTCTTCGGTGAACTGGCTCGGCATGCTTGTCCCCGCCGACACGGATATCATCA
+TTGTGGCCGACAGCAAGGACGTTGCCTGCCAAGTGGCAGACCAGTTCCGGCGAGCGGGCT
+ACGACCGCCTGATCGGCTATGTTCCCGACGGCGTGGCCAGCTGGGCTCTACAGGGCAAGC
+CGATGGACCACCTGCCCCAGCTAACGCCCGCCAGCCTGAAGCATGTTGTTGGCAGGTACG
+GCAACCACGTGATTCTGGACGTGCGCACCGATGCCGAATGGGCCACCGGCCATATCGAGG
+GAGCCATTCACCTCCCCCTCCCGCGACTGGTCAGAGAGGGCATCGATCTCGGCAAGGACC
+GCCACATCACCACAGTCTGCCGCTCCGGGTACCGCTCCAACGTCGCTGGCAGCTTCCTGA
+AATCCCAAGGCTACGAACATGTGTTCAGCCTGATCGGTGGCATGACCGCCTGGCAGGCCG
+CCAACCGTTGACACCGGTACCAGCCGGGTCCTTTGCCCTCCTTTCCCCATCAAGCAAAAA
+CCCCCGCCTAGGCGGGGGTCAAAGCGGTTCCTCAGGGGAACACGGAACAGTTCTGGTATG
+CCCGGCGCGATTCGAACGCACGACCTTCTGCTCCGGAGGCAGACGCTCTATCCAGCTGAG
+CTACGGGCACCCATGAAAGGGAATCATACTGTACAGCTTGCCCAACCTAACGCAAGTGGT
+GCAGCTCGCCGTTTTCAGGCGTCCCCGTCCAATTCGAGCTCACCGAGATCCATTTCGGCG
+ACCACCGAACGCCCAACCAGTTCGACGTTGACGGTGACCCGGGTCTTGCCCTTCCGCTTC
+TCCACAACCCCGGTGATGCCCGCCAGGGGGCCATCGGTGATGGTGACCTGCGTGCCCGGC
+TTGATATCGGGCATAACTTCCAGGTCCACCGTCGCCTGGGCGGTCTCCAAGTGCTGCAGC
+TCGGTCAGTTCGGCGACCAGCGTCCTCTCCTGGGCCTCCCTGACCTCCACAATGTGGACA
+ATGCGATGGCACTCGAGGAAGGTGGTGCGGGTGTCGGGGCCGAGCTGGACAAACACGTAG
+CCGGGGAACATGGGCAGGTAGGTTTCGACCGTGCGGCGCTGGTAGCGTTTGCGTTGGCGC
+AAGAGAGGCAGGTAGCAGGGAATGTCGTGCCGCTTGCAGTAGTCGTCGACGACCTTCTCG
+GTGCGGGGACGGCAATAGGCGGGATGCCACGTAAGCCCGGGCTGGCTAGCTATGGAAATG
+GACATGGTAAGAGGAATCAGTCGAGAAAAAGTTCAGGGGCGATGCGTTCCACAAAACTAC
+GGCAGAGCTGGGTGACTTCCTCAGCGCTGCCGCAAGCCATGGCTTGGTCCACCAATTCCT
+CAGCTTCCAGCATATTGATATCGCGTACCAGATCCTTGACGATCGGGATGGCGACGGGAC
+TCATGCTCAATTCGTGGATGCCAAGGCCGAGGACCAACGGCACGAAGAGGGGTTCTGCGG
+CCATCTCGCCGCAGATGCCGACCCAGCGCCCATGCTCGTTGGCAGCACGGACGACACGAT
+CCAGCAGACGGACGACGGAGGGATGGCCGGGTTGGTAGAGGTACGAGATGTCGGGGTTCG
+AACGGTCCACAGCCATCATGTACTGGACGAGGTCGTTGGTACCGATGCTGAAGAAGTCCA
+CGTGCGGCGCCAGCTTATCCGCGATGAGGGCGGCGGCAGGAACCTCAATCATGATGCCAA
+CGTCGAGGTCCGGGTTGTGGGGAATGCCCTGGCGCTCGAGCTCCGCCTTGACGTCGTCGA
+GAATGGCCAGCGTGGCGTGCAATTCCTCCATGGTGGTGATCATGGGGAACAGGATGCGGA
+CGCCACCGTGGGCGCTGGCGCGGAGGATGGCCCGAAGCTGACTGCGAAAGACGTCTTCGC
+GTCGCAGACAGAAGCGGATGGCCCGCATGCCGAGGAAGGGATTGATCTCCACCGGTACGT
+CGAGATGGGAGAGGAACTTGTCACCACCAATGTCTAGCGTGCGGAAGACGACCGAGTGGG
+GAGCAACATCCTCGGCGACCCGGCGATAGGCCGCGTACTGCTGCTCCTCGTCGGAGATGC
+TGCCGCCCTTGACGAAGAGGAACTCCGTCCGGAAGAGCCCGATGCCGACCCTGTGCACCC
+GACGAATCCGTTCCACTTCCTCGGGCAGTTCGACGTTGGCGGCCACGCTGACGTGGAAGC
+CGTCCCGTGTCTCCGCGGGAAGCAGGGCGTTGACCTCCAGTTTGGCGCGCCACGCTTTCT
+CCTGCTCGATACGTTCATGGTACTTGACGAGAGTGGCGTTCTCGGGACTGACGACAACCC
+GTCCTTGGGTGCCGTCCACGACCAGCCTGACCCCGTCCCCGACTTGGGCCAGGGACTCGC
+CCAGCCCCACAACGGCCGGAATGCCCAAGGCACGGGCCATGATGGCGGTGTGGCTGGTGC
+GACTGCCCATGGCGGTAACAAAGGCGAGAACGTTGTCGCGATCCATGCCTGCCGTATCGG
+AGGGCGACAGATCATGGGCGATAATGATGCAGGGCTCGGGGAGTTCGGAGAGATCGACAC
+TCTCGCTGCCCAGCAACTGACGGAGGATACGTCCGGCCAAGTCCTGAATGTCGTTGGTGC
+GCTCGGCAAAGAAGGCGCTGCCAGCCTTGACGAGCTGGTCGCAGAACTCATCGACGTAGT
+TCTTCAGCACGAATCCCGAGTTGCGGCGCGTGTCTCGGATACGGTCGCTGACCTCCTGGT
+CGAGCATCCCGTCCTCGATGACCATGACTTGCATCTCCAGGATATCGACCAAGTCTTGGT
+TCTTCTCGTCGCGGGCGCGATCGCGCAGTTCCTCCAGCTCCCGGCGGGATTTCTCGAGAG
+CCGCACGGAACCGGCCCACCTCGTCCTCCAGCTGGGAGACGGGAAGTTCATGCTCCCGGA
+CACTGACCACGGAGGCGCCAACCACGACGGCCTTGCCGATCACGGTACCGGGGGACACCC
+CCGTTCCGGCCAACACGGTCTCGCCGGGTTCATTCCTCGCCGAACTTGTCCGAGAAGAGT
+CGCTCAAGGGCCTCTATGGCCTCCTCTGCGTCATGCCCTTCGGCGGTTATGGTCAGCTCC
+GTTCCCTTGCCTGCGGCAAGGAGCAGCAGAGCCATCACGCTTTTGGCGTCACTCACGGTT
+CCGCCCCGTTCGAAGGCGATCCGGGACGAGAAGGTCTTGGCCAGCTTCACGATCAACGTC
+ACAGGACGGGCGTGCAGCCCCAACTGGTTCTGCACGATAACCTGGGTTGTTCTGGTCTGT
+AACTGTGCCATCGGAGCCGAGCCGGGGGTATCTGTACCTCGCTCCCCCGTGTCTATCGCT
+AGTGCCTGGAAATATAGAAAGAAAGAGCCCCGCCAAGGGGCAAACCGCAGCAAGAGCGTG
+ACCGAAGTCCCTACCATCACTTGCGGTACCGAGTACTATAGGATTGCGCGGAGGAATGTC
+CACCAACCCACGATGTTGTCGCTGGTTGGTCCCTGGTGAGAGAAAAGGCGCGGCGGCACC
+CACCCGAAGGCAGGCGCCGCCGCGCCAGAGAGAACTAGGCTCGGTGCTAGTACCGGGGAC
+CCCGGTCGAAGCCGCCACCGCCGCGACGGGGGCCGCGGTCGGAGCGCGGACGCGCCTCGT
+TGACCGTCAGGGCACGACCGTCGAGATCCTGGCCGTTGAGGCCCTCGATCGCGGCCTTGG
+CCTCGTCGTCGTTGCCCATCTCCACAAAGCCGAAGCCCTTGGAGCGGCCGCTGTCGCGAT
+CCATGATCACGCGAGCCGAATCAACGCTACCGTATTCTTCGAACGCGGTACGGAGGGCGT
+CGTCGCCGGCGGAGTAAGGGAGGTTGCCAACGTAGATATTCATCGTGTGGACTGTTCCTG
+ATTCATCTAGGAGTGAGGACTCGGTGCCGCCCCGTTTTGGACGGCACACGAGACCGGGGT
+CAACTGATTCTGGTCTGGCCTAGTACCGGGGACGACGGTCGAAACCGCCACCGCCACCGC
+CACGACGGGGGCCGCGGTCGGCGCGGGGACGCGCCTCGTTGACGGTGAGAGGACGGCCGC
+CGAGATCCTGGCCGTTCAGGCCCTCGATGGCGGCCTGGGCCTCGTTGTCGTTGCCCATCT
+CCACGAAGCCGAAGCCCTTGGAGCGGCCGCTGTCGCGGTCCATGATGACGCGAGCGGAGT
+CAACGGCACCGTATTCCTCGAAGGCGGTACGGAGGTCATCGTCGCTGACGGAGTAGGGAA
+GATTGCCGACGTAGATATTCATGGTCTGAATGAATCCTGATTCGTTCTGGACTGGTGGTC
+CGGTGCCGCCCAGATGGTTGCGGACAGCACCGAGCCGGGGTCAATTCTGGTCTCGACTAG
+TACCGGGGACGACGGTCGAAACCGCCACCGCCACCGCCACGACGGGGGCCGCGGTCGGCA
+CGAGGACGAGCCTCGTTGACCGTCAGGGGACGACCGCTGAAATCCTGGCCGTTCAGGGCC
+TCGATGGCGGCGTTCGCCTCGGTGTCGTTGCCCATCTCCACGAAGCCGAAGCCCTTGGAG
+CGGCCGCTATCGCGATCCATGATGACGCGGGCGCTGTCGACGCTGCCGTATTCCTCGAAC
+ACACCGCGCAGCTCGTCGTCATTGACGGAGTAGGGAAGGTTGCCTACGTAGATATTCATC
+GGGGGGAGATCCTTGCTCTCGCCAAATGGTACTCGTACGTCCCGGCGTCCACTTTGGCGA
+CCATGGACAGGCGGGGGGAGTCCGCAGACTCACAGAAAGGGAATTGTGGAGGGAAGATGG
+GTAGAACCCGTCTTGCAGGATGCCTGAGCGACCTGCGTTGCTCAAGGGTCGCTGCTGCAG
+AATCCCGCGAGAGCCATCAAAGCCTCGCGATCACTGTGTACACCAACCGGCGGTCAACAA
+CATCTCGCTGCACTGTCTGTCCGCAGGGCAGAACAGCCAGCCCGATTTCTACGCCTCTGT
+CCCCTATCGGGCGTCCGAGCAGAGACGTCGCCACTAGTGCGTGGCGAATTCTGGGGCGCC
+GTTCGGGTGCGGCGCGTAAGAAACCAGCCTTCGACCTCCGGATGTGTACTGTAGAGCTTA
+GTCGGCGGCGCCGACTCCTGCATGCAGCGGGTTCGCAAGAACCTGCCTTCGGCTAAGAAT
+GTACAGTCTGCAATAGGTCGTGCAAGTGCGACACCCAAACAACCGCAGATATTTGTGAAA
+ACCGAGGAGCCCAGACCAGCCAACACGAGGGCCAAAAGCCCCGGTAAACGGCCGCGCAAA
+CTGGGCAACCAACCACTCTTCGGACCCTGATTGGGGGCCTGGAAATCGCGCCTGCTCGGC
+AACCGAAAACAGGCACCGAAACTTGCCCTGCCCGACGCCCGAACCAGAGGCAAAGTGGCA
+GCGCAAATGATGGGCCGCTAGGTTCCCAACGTAGCTTGTTTGTGTATCGCCAACGAGGAA
+CCCGCATGAAACCGCATCGGCTCGCCATCTTCCTGGGCACGTTCCCCATGCTGTTCTCTC
+TCCTGCTGGCCGGGGAAGGCACCATGAAGGAGGCCGGCAAGAGCCTTCGCTTTGGCAATG
+GTCGCCTGATCCTGACCTTTGACCGGGATACCGGCATCTGGACTGGGCTGGAGGCGTCCG
+GCGGCGCGGTCTGCTTCCGGCGAACGGCGGACAGCCCCTCGCTGAACGTGCAGGTGGACG
+GCAAGCCGGTGTTCGGAGCGGACAGGAAGATGAGCCTGCGCGAGCAGAAGGTCGTCCAGC
+TCCCGACAGCCAGTCGACTGGAGTTGACGATGGGACAGGGCGATTGGGCGGTCACGGCCG
+CCTACACGCTATGGGATTCAGGCACGCTGCAGCGCCAAGCCACGTTCGTGTACTCCGGTC
+CCAAGCCGGAGGGCGACCACGAGGTCCGGAACGCGCTCTTCGTTCTGCCCGATGTGGGTC
+TGGCCGGTACCGACGCCTTCTGGTTTGCGACGGCGGAATACCCCCCTCGGGACCACCCGT
+TCCGCCACACCGATTCGGGCCGACGCTTCGGCTTCCCCTTCTCCGAGTCCACCTTCCACG
+GCTTTCTTGCGCGCGATCCCCAAGCCAAGCTGAGTCTGGTTTCGGCCTACTACACGGAAG
+ACGAACGGGCCAAACTCCTAGTACAGGAGGGCAAAGGGACCGCAACCGCGTTCCACACTC
+ACTTGCTGGCAGAAACGCTCCGTCCCGGGCTGCGGTTCGAGGTGGGCAGCCAGTTGCTGC
+GGGTCGTTCCCGGCACACGTCAGGACGCACTTCGAGCCCTGCAAGGATTCTATGACCTGC
+CCGGGCTGCGCACCAAGATCGGCATGCCCCCCGACACGGGACGGCAGATCTTCTACTCGG
+CTCATCCCGGCGGCACCATCGATTCGTCGTTCCGGGACGTCGGCGGCTTCGCCAACTTCA
+CCAAGCTGTTGCCGAGCATCCGGGATCTTGGCGTGAACACCCTCTGGTTGATGCCCTTCT
+GGTATGGCCCCGTGTACGCTCCCTACGACTACTACCGCCTCGATCCCAAACGATGCGGCA
+CCCCGGCGGAACTCAAGGCCCTGACCGACAAGGCCCACGCTCTCGGCATGCGCGTGCTGG
+GCGATCTGATCCCACACGGGCCGCGCGAGGAGCCCGGTGCGAAGCCGAGTTTCGCCGAAC
+AACACGGGGATCTGGTCTGCCGCGACAAGGACGGGAAAATGATCCAGTGGTGGGGTTGCC
+ACTACTGCGACTACGCCAATCCGGGCTGGCAGGACTACATGGCCAAACACGCCGCGTACT
+GGGTGCGCGAATGCGGGCTGGACGGCTACCGGGTCGATGTGGCGGCGGGCGGCGCGCCCA
+ACTGGCGGCCCTACGACCACAACCGGCCGAGCTTCTCCGGCCTGCACGGCGGGTTGGCGC
+TGCTGCGCAAGGCCCGCGCGGCCTGCCTGAAGGAGAACCCAAACACCATCTTTCTCGCCG
+AGAGCACCGGCCCGACCATGTATTCCGCCGTCGAGCACGGCTACCACTGGGCCTTCTCGA
+CTCTGCTGGAAGACCACGTGCTCAAAGACGCTCCCGCCGACTTTGTCCAGGCCATGTCCG
+GCTATCTGGAAAACCAGACCTATGCGTTCCCGGCGGACGCGTTCCCGATCCGCTTCCTGA
+CCAACCACGACAAACTCCGTGCCCGCTACCGCTACGGCCCGAACCTGCACCGGACGTTGC
+TTGCCCTCTGCGCCTTCATGAAGGGCGCTCCCCTGCTCTACGAGGAGGAGGAAATGGGCA
+ACGAGGACTTCATCGCCAAGCTGTACCGCATTCGGCAGACCTACGACGAGCTATCCGTCG
+GCACGGTTAGCTACCGGAGCATCCCGGTCGAACCCAAGCATGTCTTCTGCATCGAGCGCG
+AGTACAAGGGCAAGCGCAGTGTCGTTCTCATCAACTTCTCCAACCAGATGTCCGAAGTGA
+AGCTCTCGCTTCCAAAGTCAGACCTGAAGAATCCCGGCATCTACGAGGCAGTATCGGGCC
+AGCGAGTCGATTACGCACAGGATCTCACCCAGTCCCTTGATCCCTACGCCTATGCTGTGC
+TCGTCATCCGCCAACGGGATGAATTGCCGCCCTCCGTCCCCAAGGAGAGAGGCGAGAGTC
+CGGCAGCTCCCGACGGAAGAGCGATGGATATCAAGATCACCCAAGAAGATAGCCTGACTC
+GCGTCTCGACCCCGCTCTACAGCGCGGTCATCGACAGCGCGCGTGGGGGCTTGCTACAGG
+AAGTGCGTGGTGCCGACGGCAAACTGCTCGTGAATGGTGTGGAACTAAAGGAAGGTCGGC
+GCAAACTCTTTGTGGGGCACGATTCTGTGGACTTTGCCGACTGTAGCGTCCCGCTCAGGA
+TTCTCGCCAGGGATCGGCAGTTCCCGGATGGCGGGAAGGTCTCCCTTCTCAGGGGCAGAG
+CAGAGTTGCGCGACGGCGATGGGCATGCCTGGATGGACCTCACGGTTCTCTACTCTCTCA
+GGGCCAAGAGTCTGAGCCTTAATGTTTCCCTTACTCCCCAATACAGGTTGTCACCAAGCA
+AGTCCGACCTCGGGATGAAGATCCACTTTGTGCCGACCACCCACTGGTTTGCGGAGACTG
+CGGAAGGGAACCTGCTGGGACATGTCATCCGGCGGCATCCTGCTTCGCATGGGTTTTCCG
+GGCGGTATTGGCATGGTGCCGGGGAGGCGTTCTTCAATGGCTCTCTGTATCCAGTCGTTG
+GCGAGTTCGGCGTTCTGGACACCAATCGACGGATTGCCCTCGGCAGCATGGCGTTGCGAC
+TTGATGGAGCCCCGCTTCCCGTGCGTTTGCTGGAGGACGAGCCCCCCGGTTCCCCGGTGG
+TTTTGGGGGGCCCGGCAGCAGCCACCGCAGACATCCCGTTACTTAGGGGGTCTCAGCGTG
+CTGTGTGGCAGCAAGGAAAAGCGAAAGGCATGGTGGTCACACTGGATTTCCGGTCCGTGC
+CCGCACGGTTCACTCAGTACCCAGATAGTTTCGGCGTTCGGGGATGGGATACCGGAACGC
+CGAAGCTGTGCTACCGCGGCGGCTGGTGCACGTTCGGCCCTGAGTACCTGTTCCGTGGCT
+ATGGAATGCGCGCGACCGTGGTCCGATCCCACGGTGGGGAGTTGACGGCGCTGACCGATG
+CCGCTGGGAATGGCCTGCGCGTGACGGATGCGCGGTTCTACACCGACCAAGGCCTTTTCG
+GCGACTGGCGCGACCCACGCGGCGTTCTGCGCAAGATGAGCGCGAGCAATGTGAACGACC
+CGGAACCGGACACTCAGTTGCTGCACCTCTTCGAGGGACCACAGGATTCCGCTCCTCTCC
+GCTTCCGCAGCTTCTTCCGCCATCCGCACGCAGGAGGCAGGTCGCTGCTGAATCCGAGAG
+TCGAGTATGAGATCTCGTACACCCCGCCGACCGAGAAGGGCAAGGGGCTGCGAATCGACT
+GCGGCGTCCGGCCGCACCTGGTCAAGATCGGGACCGGGGGATTCCTGGCCTACAAGATCA
+GTCTGGGCGGTTGCGACCAATGGCAGGTGGACGGCGGCGAGTGGCAGCCGCTGCCAGCGA
+AGGGAGGGCGACTCTGGGAAAACAAGGAGGCCGGGCATCTGCCCAAGACGTTGCTCTTAC
+GCAACAGCAAGACAGGTCTGTGGACCCGGTTCTCCGACTTTGTGGGCGGTCCCGACCAAG
+TGGAGAATGTGTTCCTGCACGCGGGGCAGGGCCAGGTGCACCTGTTTGTCGCTTTCTACG
+ATGCCGAACCCACCGACGTTCGCCCGGTCTGGCGGCGCGCCGCCTTCACCATGCAAGCCG
+GAGGCAAGCAATGAGAATCGCTACCTTCCTTCTACCATTGCTGGTCGCCATCGCCGGAGC
+CGCCCCCAAGGTCGAGACCGGAACCGATGGTCTGCGTGTGCGCACGGCGCGCTACGTGGC
+TACCTTCAGCACGGATTCCGGCCTGCTGGCGTCTCTGGCGTTGGTCGACGGTACGCCATT
+GCTGACCAGTCCCCGCCTCTACGCCGATGTCCTGCCGGATGGGCGCAAAAACTTCTCTGC
+CAAAGCCAAAGCCGCACCCAAGGCGAAGCCCCAGCCGGATGGCTCTCTGCTGGTCGAGGT
+GGCAGGGGCGCTGCTCGACAAGGACGGCAAACCACACCCGACCTACCCCTTCACCTATAC
+AGCCAGCTACCGGTTCGACGACACGGCACAGGTCCGTGTATCTGTCTCGGTGATCCCCGG
+CTTCGACAGCGACGCGGTGTTCGGTTTCCTGGGGCAGGTGTTGAGTACGGCGAGCCAGCG
+GGAGTTCTTCGTGAACACGGCGGACGGGCTGATCTCCGAGATGGCGGCCACCCATAGCGG
+CCGCACGTACCAGTCGGAGAGCGAGCCGCTGGATCTGAAGGACCCCTATCTCGGCGTGTT
+GCTGAAGACTGGTCAGATCCTGCAGTTCCGTCTTGTCTCGGGGGCGGAATCCCTGCTGAA
+CGTGTTCTTCCACGATTCCGGAGCGGGACCGACCCACCTTTTCCTCTGCCCCCTGAGCGG
+CTCCAACCCCCGCCAAGCCAAGACGGGCAAAGCCTGGCAGCAGGAACTGGTGATCGAGGC
+CATGCCGCTGGCCGAGTGGACCAAGAGCCGCTGAGCCGGCGGGCGGATCGCCGAGCATCG
+TGCTTATCTGCATTTGGGGTCCACGTCCAGCCCTGTCTTGCGCAGGATGGCTTGCCCGTC
+AGGTCCGGTCGCGAACTCAATGAAGGCCTTGACCAGTCCAGGCTGTGGCGTGCTCATGGG
+CGTTCCGACTACCATGTGTTGAACATTCCCATAGCGCTTCAGGCCTTTGGACTCCACTTC
+TTCCACCTCGTCCGCCATCGCGGACTGCGTGAAGCTCCAGACCACGGCACCGTCGATGCT
+CCCACCCGCCACGAGCCGCGCCACATCGTAGTCCGTGTCCCGGACCCGGATGTTGCTGGG
+CTCCGTGTCCGGGCCTTTCGGTGGCTTCCGGTACCCAGACTCAGAGATCCGCGCGAGCAG
+GCACGCGCCCTGCCTGGTCCTACCATGCACCATGCCCGGCTTGCCGAGATCAAAGGCGGA
+CCGGATTCCCTTGGGGTTGCCTTTCGGCACGATCAGGCACGGGGTGAACCGCCCAAGCTC
+GGCAGGCCTTCCGCCGCCATTTCCTCTGGCCCGAAGCAGGTTCTCTTCCGCGCTTCCGCT
+CCATGTGTTGGCATACAGGAACAGACCGACATACTCGTCCCGCTGCAGACGTTTGTTCAG
+TTCGTCGGGGCGTATGTATCTCACATCCACTCGGACGCCCTGGCTTTCGGTGAAGCCTTG
+GATCAGCTTCTCCGCCACCGGTTCCAGGTCCACCAGGCAGTACATACGGACATGGTTTGC
+CCGTGGCTTTCCCCGCCAGCTGCAGCCACCACACGCCACCAACACGGCGACGAACAGCAT
+TGCGCGTTGCCATCTCATTCCCAGCACTCCCTGTCTGTCTGCCTGCGCCACTCACGCCAG
+AACCAACCGGCGACGGACGATAGCCGTTCCCAGACCATGTTGCCAGCCGTTGGCGGCCTC
+GCAGCGCAATCGTCGCTTGTCCTGCCGTTTGCCAAGCGCAAGACGTCTCCGAAGGACTAC
+AGTACGCGTCATGTTTCACCCGCAACCGGAGGCCTACCATGACTGCATTCCCCAGAACTG
+ATGTCGGTGGTGTTTCTGTATCCCGCCTGATCATTGGCACAAACTGGTTCCTCGGGTATA
+CCCATTCGACTTCCGCGCAGAGCCGCACGAACTCCGAGCGGGTGAACCACCGCGACGTCG
+TAGCAGGAATCGTCGAGACCTTCGTCGAGTTCGGCGTGGACAGCATCATGTGCCCCCACA
+CCGACACGGTGATCCCCGAAGCGATCGAGGAAGCCCGGCAACGAACCGGCAAGCCGTTGG
+TGGTCATCAGCACCTTCGCTCTGCCCGTGACCAAGCGCACCGCGCTGGACGGCTTTGACC
+TCGGCGAAGTGGAGCGGATTCTGGACGAGCAGGTGGCGCGGGACGTGGATATTGCCATGC
+CGCACCAATCCGTCACCGACATCATGCTGGACAAGTGCTCCCGCGAAATCCGGCAGATGG
+CCCCGGTCTGTGCCCTGATTCGCGACCGGAACATGGTCCCCGGACTCAGCACCCACGCCC
+CCGAGACCGTGATCTACTCGGACGAGACCGGCCTGGACGTGGAGTCCTACATCCAGCCCT
+TCAACCTCATGGGTTTCCTCATGCAGGTGGAAGTGGACTGGATCGCCCGCATTATCCAGA
+ACGCCAAGAAACCGGTGATGACGATCAAGAGCATGGCGGCGGGCCAAGTGCGTCCCTTCC
+AAGCTCTGACCTTCAGCTGGAACGTGATCCGGCCGCAGGACATGGTCACGGTCGGCACGA
+GCTCCAAGCACGAGGCGCGCGAGCTATGCGAGATGTCGCTGCAGATTCTGGACCGGCGCG
+CCACGACCCAGGAACTGCAGCGCACCCGCTCCAAAGCCAGCATCTCCCCAGCGTAGGGAC
+TACGTGAAACCTGCCAGCGTACTTTTGGCGACCCCGGATGGCGAAGGCTTCTATCGCTTC
+TCCGATCCCGTGCGCGTGGTGACGGCGGGCTCCCTTGAGGAGGTATTGCCTACCGTGACG
+GCAGTGGAGGCGGCGGTGGCGCAGGAGGGGGTGTTTGCGACGGGCTTTGTTTCCTATGAG
+GCCGGGCCTGCTTTCGACCGGGCGCTGGCCGCCTATCCCCCCGGAGAATTCCCGCTGGTC
+TGGTTCGGCCTGTACCGCAACCGGGAGGTCGTGCCGAAAACCGAGATGCAGGATGTGCCG
+CCTCTGGCTTGGCGACCTTGCCTCGACCAAGACGAGTACGTGGCCGCGATCCGGCGCGTG
+CGCGAATACATCGAGGCGGGGGACACGTACCAAGTCAACTACACATTCCGTCTGCACGCC
+CCGTTCGCTGGGGACCCAGAGGCCCTGTTTGCTCGTTTGGCATCGGCTCAAGCGTGCCGC
+TACGCCGCCTATGTGGACACCGGGCGATATGTGGTCTGTTCAGCCTCGCCGGAGATGTTC
+TATACGCAGAATGCAGACGTGTTCCGCTCGCGACCGATGAAGGGGACGCGGCCTCGCGGC
+ATGACCTTGGCCGAGGATCGAGCGCACCGCGAAGAGCTGCTTGAGTCGGAGAAGGACCGA
+GCGGAGAACGTGATGATCGTCGACATGGTCCGCAACGACCTCGGCCACATCGCGGAGGCG
+GGGACTGTCCATGTTCCGGAGCTGTTCTCGGCGGAGCCGTACCCCACCGTCTGGCAGATG
+ACCTCGCTGGTGGAGGCGCGGTCACGGGCTGGTTTCGGACAGACGCTCAAAGCTCTGTTC
+CCGCCCGCCTCGATCACCGGCGCTCCGAAACCGCGTACGACCGAGATCATCCGCGAACTG
+GAAACGACCCCGCGCCACATCTACACGGGCACCATTGGCTACCTTGGCCCCGAGGATGCC
+CGGTTCAACGTCGCCATCCGTACGGTCCTGATCGACCGACAGACCCAGCAAGCCGAGTAC
+GGCGTAGGGGGCGGAATCGTCTGGGATTCCGACCCGCTCGCCGAATGGGAGGAATGCATG
+ACCAAGACACGTGTGTTACGGACGGTTCGCCCCGAATTCTCTCTGCTGGAGAGCCTGTTG
+TGGACTCCCGACGAGGGCTATGCGTTGCTTGATCGGCACCTGGCACGTCTATGCGACACG
+GCCGAGTACTTCGGCTATCCTGTAGACGTTGTATCCGTTCGGCAGAAGCTTGAGGAGTTG
+GCCGGGAACCTGGAACCTGTGCCGAACAAGACCCGGTTGCTCGTGGATCGTCACGGGGAG
+ATCACGGTCGAAGGCAGCCCGCTGGGACCGGCGCCCGACGCACTCGTCTGGCGGGTATGT
+GTGCACCCCGAACGGGTCGATTCCCATGATCCCTTCCTGTATCACAAGACAACCCATCGG
+GCGGTCTACACCCAAGCCGCTGCCGCCCACCCCGACTGCGACGATGTGATCCTCCAGAAC
+GAGCGCGGGGAGATTACGGAGTCTTGTCGCGCCAACGTGGTGGTCGAGATGCCTGAGGGA
+CGATTCACGCCACCGGTCTCCTGCGGCCTTCTGGCGGGCACGCAACGGGCAGAACTTCTG
+GCTCGTGGCGAGATCACCGAGAAGGTGTTGACGCCGGAAGACCTCTACGCGGCCACAAAG
+GTGTTCCTCATCAACTCCGTGCATGGCTGGGTTGTCGCAGAGTTGTCCGACTCGTCGGAC
+TAGTCGGACCAGTCGGACCCGAACTCACCGCCCCGGGCACGAGCGTCGCGCAACCTGAAC
+GCCCTGATTCAGCCGCCTTGTCGTTTTGGGGAACCCAGAGGAAGGCAAGGCCGGGGACAG
+GTCAGGACAGGAGGGGAGGACCATGACCCAGGGCTTGGGCCCTGGGCTGGTATCTCCCGC
+CCCATTCGGGGCTGAAGAGAAGCCAAGAGGAGGGCTGGGGGAGATGGGTGCCTTCTACGC
+CAAAGGCGTTACCTATTGGCGGTCCGTGACGACGCCCTGACCTGCCACAGTGCTCCGCCA
+ACGTGCCATGCCTTGCACCATGGTCGAGCAACCGGGCGTTCAGCCTGCGCGTGCCGCTGA
+GCTCTGGTCTGACTGGCCTGTGCGGCAACAGAAACGCCCCGCAACGATTGCTCGTTGCGG
+GGCGCTGAATCACCAGTCGCTAGTGGCTAGCGACGGATCGGTCGACTAGTCGAGGTCGAA
+GGGGCTGACGATCTCGCCCTTGGCGGCCTTGATGGCCTCGAGGCGCTCGCGCTGGGCCTT
+CATCTCGGCCTTCATGATCTCGGGAGTGTCCGTGACCTTCGTGGAGTAGATCTCTTCCAT
+GCGGTCGAGCTTGGCGATCAGAGCAGGGATGTTGACGCGGAACTGGAAGGCGTAGTCTTC
+CTTCGCGTAGTCCTCTTTCAAGACCTGCTTGAAGAGCTTGGCGAGATCCTCGTACTTCGG
+GATCAGGCCGTAGCCGGCGTCGATGGCATCGGCTTCGCCGTGGATCCGCAGTTCCATCCA
+CTTGACCCAGACGGACTTGTCCAACTTGCCGTTGGTGTAGCTGCCGTCCTTCTTGAGGAA
+GTAGTTGGTGCCGAAGACCTTCGGGCGCTCGATGTCCTTGGCGAAGTCCAGGTTGTTCTG
+GATGTAGCGGCCGACGGACATGGAGAGGAAGTCCATGTTGGACATCACGTTCCACTTACG
+GACGCCTTCCGCGCCGATGGTGGCGGCGGTGGTTTCGGACTCAAGCATGGCACCCATGGT
+GCAAACGCCGTGCTCCCAGCTGTAGGCTTCGCGCACGGGGGCGTTGGTGTCGCTGTCGCG
+ACCGCCGTAGATGATGCCGCCCATGGGCATGCCTTCGGGCTTGTCCCACTCGGGATCCTT
+GTTGGCCAGGTCGTTGATGCGGATGGTGTAGCGGGCGTTCTTGTGGCTGCAGCTGGCGAC
+CTTGCCATCCGGGCCTTCCATGCCCTCGGTCCACTCGGTGGAGCAGTAGTTCATGCCCGT
+GGCCGGGATGTCTTCGCCCATGCCCTGCCAGTAGGGCTTGCCGTCCTTGACGAGGATGTT
+GCCGAAGATCAGCTCGCCGGGCGTGTGCAGCACGTCCCAGATCACCGGATCGTCCTTGCT
+GTTCACGTCGGTGATGATGCCGAAGATGCCACTCTCGACGTTGACCGCGCGGAACTCGCC
+ATCGATGACCTTGAAGTAAGCAAGGTCGTCGCCGACGATGTTCTCGCCGGGGATCATGGC
+CGTGGAGGTCTTGCCGCAGGCGCTGGGATAGGCACCGGCGAGGTAGGTCTTGCGGCCGTT
+GGGGCCATTGCAGCGCATGATGAACATGTGCTCGGCCAGCCAGCCTTCCTTGTCGGCCTT
+GCGGATGGCGAGGCGCAGGGAGAGCTTCTTCAGACCGACGGTGTTACCGGCGTACTGGGT
+GTTGACCGACCGCACGCAGTTCCGGGTGTAGTCCATGTACACACGGTTCAGCTCGACGTT
+CTTGGAGGTCATGCGCTCGGTGACTTCACCGGTGGCGTGCAGGTACTTGAAGAACTCGAA
+GTTCGGGTCGGCGGCGTTCTGGCGCTTGAACTCTTCGTAGCCGCGACGGTACAGCAGCTC
+TTCGGAGTGGACGACGTAGGCGCTGTCGGTGATCTGCAGACAGGGGATCGAGAAGCTGCT
+GCCGGTGGTGCCCAGGCAGAAGAAGCGCACGAACATCTCGCGGCCCTTGTAGGAGCCACG
+CTGAAGGTCGTCCATTTCCTTGACGCCGGCTTCGCGTTCCATCTGGTTCAGGTTCTTGTC
+CAGCTCGACATCGGCAGGCACCAGGTACTTGGTGACTTCCTTCTTGCGCGCTTGGTCGTA
+GTAGTTGTCGAAGTGGACCGTGTGGCCGTTGGTGGTGAGCTGGAGCTCTTCGAGACCGTC
+GATGGCCTTCACGCGGCAGTAGGCGGCATCGCTGTCGCTGTCGTCGCCGACGAAGACGGT
+TTCGGGGTGTTCCTAGGCTGTTTCCTGGTGGGATCCTCTAGAGTCGACCTGCAGGCATGC
+AAGCTTGAGTATTCTATAGTCTC
+>NODE_9_length_20531_cov_182.121_ID_17
+CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGG
+TCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGG
+GACCACGGTCCCACTTGTATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAA
+TGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAACCTGTAGAACGGAGTAACCTCGGT
+GTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATTTTGCG
+CACGGTTATGTGGACAAAATACCTGGTTACCCAGGCCGTGCCGGCACGTTAACCGGGCTG
+CATCCGATGCAAGTGTGTCGCTGTCGACGAGCTCGCGAGCTCGGACATGAGGTTGCCCCG
+TATTCAGTGTCGCTGATTTGTATTGTCTGAAGTTGCTTTTACGTTAAGTTGATGCAGATC
+AATTAATACGATACCTGCGTCATAATTGATTATTTGACGTGGTTTGATGGCCTCCACGCA
+CGTTGTGATATGTAGATGATAATCATTATCACTTTACGGGTCCTTTCCGGTGATCCGACA
+GGTTACGGGGCGGCGACCTCGCGGGTTTTCGCTATTTATGAAAATTTTCCGGTTTAAGGC
+GTTTCCGTTCTTCTTCGTCATAACTTAATGTTTTTATTTAAAATACCCTCTGAAAAGAAA
+GGAAACGACAGGTGCTGAAAGCGAGCTTTTTGGCCTCTGTCGTTTCCTTTCTCTGTTTTT
+GTCCGTGGAATGAACAATGGAAGTCCGAGCTCATCGCTAATAACTTCGTATAGCATACAT
+TATACGAAGTTATATTCGATGCGGCCGCAAGGGGTTCGCGTCAGCGGGTGTTGGCGGGTG
+TCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCG
+GTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCCATTCGCCATT
+CAGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTG
+GCGAAAGGGGGATGTGCTGCAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCA
+CGACGTTGTAAAACGACGGCCAGTGAATTGTAATACGACTCACTATAGGGCGAATTCGAG
+CTCGGTACCCGGGGATCCCACGTACAACGACACCTAGACCACCCCCATGGCCACCATGGC
+GTAGATGCTTCCCCTTTGAATTCCCATGAACAGAAACTGAAGGAGATCGGTAAAATTGAT
+ATCGGGTGTCGTCATGTTCCCACTGCTGTATTCTTGTGAATGTGTTCCGGTGCCGGGTCC
+CATCCGATAAAATATTGTCCGCTGTCGCAGCGGAATTGCGACAGCGGACAATATGACCGG
+TTCAACAGATTGCCGTCTTCATGATCCGGCAGATTATTGGTGTAAAACGACAAACTTTCC
+GTTCTTTACGGTCAGCATCTCGAATGCATTCTGGTTCAGCCCGCAGTGATTGGTCTTGGT
+ATAGTGAAAAACACCGGTAATCCCGACAAAGTTGGTATGTTCAATTACATTGCGGAGTTT
+TGCGGGATTGTCTCCGACCTTTTTCAGGGCCTTTGCGAGAATTGAGATCGCATCAAAGGC
+ATGCCCGCCGAATGTGGAGGGCGGTTCTTTGAAGGCCGCCTCGTATTCTTTTTGGTATTT
+CATCAATATGGCTTTCTGGGGATTGCTGGCGGAAACAGTGTCTGCCGCCAGAAGACGCCC
+ACCCGGAAAAATGAGGCCGTTTGCCGCCGCACCCGCAGCCTCGACATACTTGATGTTGCC
+GAATCCATGGCTCTGGTAGAGCTGGATTTTCATTTTAAGCTGGCGCATGTTTTGCGGAAC
+GATCGACTGGGCCGGCACGATGGACCAGTTCACGACCGCCTGGGCGCCGGAATTTCGGAT
+CCGGATCAGCTGGGCCGTCATGTCCGTATCGGTCGGATCATAGGTTTCATCCGCCACAAT
+TTTGATCTTGTAATGGGGGGCCAGGGCTTTGAGCTGCTCACGGCCGGCAGCGCCGAAACC
+GGTCGTGCCGGTGATGATCCCGATCTTGTGGATCCCTTTTTTATCCATGTTTTCATATAT
+CCGTCGAACGGCATCACTGTCGTTCTGCGTGGTTTTGAATATCCATTTCCGTTTCGATAC
+CGGAGCGATAATGCTCTCGGCGGCAGCGCAGGAAATCATGGGGATCTTTGCCTGCTGGAC
+AATCGGGATTACCGCCATCGAAGTCCCGGTTCTGGAAGGGCCGATAATGGCGCATACATG
+ATTTTTTTTGATCAGTTTCTTGACCGCATTGACGGCGCGGGTGTTGTCGCCCTGGGTATC
+TTCAATGAAAAGCTCCAGCTTGTGGCCGTTGATACCGCCGGCCGCATTGATCTGTTTGGC
+CAGCATCTCGGCCGTGTTTCGTTCCGGTCCGCCCAGCCAGGACGCCCCGCCGGTGATGGC
+GAATACACAACCGACCTTGTACGGTTTTTTTTGTGCGGCATATACGCTTACCGCCGATAA
+AAGGAATAAGACTGCAATTGCTGTGGATAATAATGTCCGTTTCACGTAACCCCCCTCACT
+TCTTCAGGTTTAGAGTTAAAGGTCATTAACCCGGATTGAAGTTAATGCCATCGGATGCCT
+CGTGGTGTCGGCGGTCAGCCCGTTACAGGCGCAGCACCCGCTTCGATTCCAGCACGGCGA
+TGTCGTTTTCGATCAGGGTCGAAATGGCCCGGTCAACATCATCAAAACGGAAGATCACGA
+TCGCCTGTCCCATGTCCTTTTCCACGAAGGCATACATGTATTCCACATTCAGGCCGGCAT
+GTTCCATGATGGAAAGCACGTTCCCCAGCGCACCCGGGCTGTCGGGAATCGCAACCGCGA
+CAACCGCCGAAATCAGAACGGTAAACCCCTGGTCTTTTAAAGTTTTTTCTGCTTGTTCGG
+TATCGGACACGATCAGGCGGAGGATCCCGAAATCGGAGGTGTCCGCAAGAGACATGGCCC
+GGATATTGATCCCGGCGTTTCCCAGAACCGTGGCGATTCTGGCCAGCCGGCCGGACCTGT
+TCTCCAGAAAGATGGATAACTGTGAAATTTTCATGCTCCCCCCCTCACCCCCCGGTCGGA
+AAGAAACCGGCCGCTATACCGGAAACGGCGGCGCCGACAGCCCGGCGGTCTCCTCGAATC
+CCATCATGAGATTCATGTTCTGAACCGCCTGGCCGGCCGCCCCCTTTACCAGATTGTCGA
+TCACGGACATCAGTATGAGCCGCCGGTTGTTTTCATCCACTACAAAAGCGATGTCGCAAT
+AGTTGGTTCCCCGGACGTTGCGGGTGTCCGGCGGATGACCGTCCCGGTCGATCCGGATGA
+ACTGCCGGCCGGCATAATAATCGCACAGACACGCCGCGATGTCGTGCTTCGTCACATTGC
+CGGCAAGCCCCGCATAAATCGTGGTGGCCATTCCCCGCGTCATGGGGACCAGGTGCGGTA
+CGAACGTAATGTCCACAGGTGTGCCGGCCGATTTTGTCAGAATCGATTCGATCTCCGGTT
+CATGCCGGTGTGCGGCGACCTTGTAGGCCTTGAACGACTCATTGACTTCCGAAAAATGGA
+CGGTTAAAGACGGAGACCGCCCGGCGCCGCTGACCCCGGATTTCGAATCCACGATGATGC
+CGCCGGAATCGACCAGTCGATTTTTCAGCAACGGCACCAGCGGCAGCAGTGTACTGGTGG
+GATAACAGCCCGGATTCCCTATCAGATCGGCTTTCCGGATATCATCGGTATATACCTCGC
+TCAATCCGTAAACCGCCCGGGACAGCAGATCCGACGATGAATGGGGCTGGTAGGCGGATT
+CATACAGCCGGACGTCGGAAAACCGGAAATCCGCGGACAGGTCGATGACTTTTTTCCCGT
+TTTTGATAAGACCCGGAACGATGGCCATGGGAAGCTTGTGCGGCAGGGCCGTGAAGATCA
+CATCCGTCTGCCCGCAGACCCTTTCAACGTCAAAAGCCTCGCATTCATTGGAAACGACGC
+CGGCCAAGGCCGGGAAAACCTTTGCAAACGGAACGCCGGCATACTGCCGGGATGTCAGAG
+CCGTAATCCGAACCTCCCGATGGCCGGCAAGAATCCGGACCAGTTCCGCACCCGCATATC
+CGGTGGCGCCAGCCACTCCGACCCTGATCATATCGCCTCCTGTATCCGTATCCGATCCCG
+GAATCCCTCCGGGCATAAATCCATTCATAAATCTTTAAGGCGCGCGGCCCGCGCCCTTCC
+TGCCGTGGCATACAATTCACCTGCGCTGCGGCCCGCCGCGGATTACCGCAACACGCCGGT
+CGCAAATACGCTTATTGTGATTAGCAGAGCTTTGGTGCGATTTCAAGGCGTTTCATTCAT
+TTCACCGACGTTTTCCGCAAAAACCGGTTCCGGTGTCATGCCCCCTTCCGATCCTGCCGA
+ATGCGCCTCACCGGTTTAACGGCATCAGAACCCGGTGTAAAGCGCGTATCGTCTTCGATG
+GCATAATCACACATCAGCAGGTCAAGGGGATTTAAGAACACCGACCGGTCGAGACGGTTC
+ATCACCGGCCACGACAGGGTATCGACCGGTGGCAGATCGTTTGCCCGGGCCAGGGTAATA
+TGAAGGTGTGCCGGCAGCCGGATCTTCGGGGATACGATCCGCGCGATGGCGGCGAATACC
+GTCCCCGCAGCAAGGGTATCGCCCTGCCGGAGCCCGTTGTCCGGGCGAATATGGGCATAA
+AAGGTGTAAAAAGGCGCATCCGATGGAGCGCACCGGCTTTGAACGACTACCGTGCGCCCC
+AGAAGGTCATCCATGATGCGGACGATTTTCCCGTCAAAGGCCGCTGGGACCGACACGGTC
+TCATCCAGGCGGTATCTCAGCCCGTCGGACGTTTCAAAAAAGCAAAGGTCCAGGCCTTCA
+TGGGCAGAGGGTCTTACGCCGCCATCCCCCCACCATTTTTCAGTCGATCCGAAGAGCATG
+CCCGGGAAAAAAATCAACCGGGAAAAGCCGGCATCCGCCAGGCCGTTTACGGCCATCAGG
+TCGGGAATGAAGGCCGGTACGGGACAGATATCTGCGGCAACATCCGATGGATCCGCCATC
+CTGCCGGCCGATTTGAACGAGCGGCTCATTGCGGTCGTTTCCCGCCGCCGGCCTGGGTCG
+AAAGCTTGCGGTATTTCCGGGCTTCGATGTCCTTTCCCTGGGCTTCATACAGATCCGCGA
+TCCGGAAGAAATAGTCCGCCCGGTTGTCCGGATCTTCCTTGGCCAGGCCGAAATAAAGCT
+CAAGAAGCTTCAGCGATTTGTCGCCGCTTTTGATGCACAGATCGGCGTACCGGCGTTTGA
+TGATCGGATCGGCCGCACTGCCGCACATGATGCAGCGGTTTAAAATATCGGCATACAGAT
+CCCGGGCCTTTTCAATCTGACCTTTCGCCTCATAGGTTTTGGCCAGCCCGCGGTTGACGA
+TTTCATCTTTTCCATGGATCTCGAGGCATCGGGTAAACACCTTCTCCGCCTCGTCATAAA
+GTCCCACCTGAAACAGGGTCTCGCCCTGGAGCATCTGCATCGGCCGGGTCGTCTGGATAT
+CGTTCGGGGCGCCGGAAAGCAGGTTCCGGGCGTCAGCGGTATTGCCCGCCTCCCAGAGGA
+TTTCGCACAGCAACTGGTAACCCCGGATTTCCCCGGGGTTTTCTTTTAAAAAATCCTCGA
+GAATCTGCCGGGCGTGATCCGGATCGTTCAAATGCATATAGGCCGTGGCCAGCTCGACCG
+GTATCAGGGTCTTTGCAGACGCATTCTCCTCGAGCGCCCGCGACAGCTCTTTCACTGCCT
+TCCGGAATTCACCGTGGTTCAGTGCGATGTAGCCGGCCGCGAAAGCCTCCCCGTATCCGA
+GATAGGCATCCTGCACCGCTTCGGGCAATGCGCTGACCAGTACGTGAAACAGATTTTCCG
+GCGAATCATACAGTTGTGCATCCGCATCCGTTTCATCCGCCATACCTTCGGCATCGGCCG
+TCATATCGTCGTCTGCGTATGCATCATCATCTTCGGCCCCGCCGGCGTCCTCTTCCGCGC
+CGCCCCAATCATCGACGTACGCCTCTTCCCGGGCGTCACCGACCCACTCCATTTCGGGTT
+CGTCCTCATCGGCGATCAGGTCCTTCAGCTTTGCAATCTTCCCGTGGATCTCAGCGGCAA
+AGGCTTCATCCGACGTGAGTTCCATGGCCAGCCGGTAAAGCGCCCCGGCCTCCTCATAGT
+CCCTGACCGTGATCATGTGGTCGCCGTTTTCCACATGCATTTTGGCAAGCGCATTCCTGG
+CGAGGTGGTACTTTTCCATGATGCGCGGCAGCAGGTGCTTCTTTTCCGGAAAGCGCCTCT
+CAATCCGGTCGATGGCTTTTTCGAACGCCATTTTGGCATCCCCGAACGCGCCGGCTTCAT
+AATGGAAATCCCCCCGCCTTTCAAGTTCTTCCGGCGGTTTCCCCCCAAAGATGCTGAACA
+GACCCATAGTTTTCCTCTTTGTTTGAATTGATGTGACCGCTAAGATTTCGGTTTCAGATA
+GGCTTTGGCCGCGGCAACTCCCTGCTCGAATCCGTCAACGATCTTGTCCTCGCTCCGTGT
+CAGCCGGTTGACCTTGAAATTATCGGGCGGATAGATGATGTCGAAGTCATAGTTGGTTTC
+CAGATCGTCCAGCATCCGGTTGTAGTTACCGAAATGGTGCTCCAGTGAGTTCACCAGATA
+ACGGTACTGGGAATCCTTGTAGTATGACTCGTAAAGCGTCTTGATCCAGAAGGAGTCCCT
+TTCCTTGCGATATCCTTTCGGCCGGGTGAGCACCACCAGGATATCACGCTCGGGAAAGCC
+CATGGAAAGGGCCTTTTTAAAGGGAACCGAATCCAGCACTCCGCCGTCTAAAAGGAGATC
+GTTGCGATAATGGACAAACCCTCGATAGAAGAAGGGAATAGCGGCCGTGGCCTTCAATGC
+CTGCGGCACACTGTCGGTTTTCGTGCTCAGATAGAGCGTATCGGGCGGGAAATCCCGGCT
+GAATCGGGTAACCGTAATCAGCACGGGACAGGCGGTCGTTCTGAGCCTGCGGATGTTTAA
+CGGCTCATCACCGCCGATGATATGGTCCACCAGCCAGTCGAGATTCAGGATATGCTTTTC
+GGGTCGGAAGATGTTGCTCATCCGGATGAACCGGCCGCTGATCAGTTCGGTAAAAAAGGC
+GTCCCGGGCCATGTGAATCTGGCCCGCCGCATAGACGACGCCGCTCAATGCACCGGCGGA
+CGCACCGATGATTGTCTTCCACGGCGCATATCCGCGTTCGGAAAATGCCTGGAGCACGCC
+CACGGTAAAGATGCCCCGCATGCCGCCCCCTTCAAGGACCAGCACTTTTTTCCGGGGAAA
+GCCCTTGAGCCGGCTCCGAACAGATCTTCCGGTATGGGAAATGGCTTCAATCGGATTCAT
+CTTCCGTCGGTCCGTCTGCTATGACAACTTCAGCGTGATATAGTATCCCTGGTCTCCGCG
+CTGCAGCAGGATGACAATCGACTGTTTCCACCTGTCCTTGATCATCGCTTTGTAAAAGGA
+TTGGACGGTATTGGTGGCTTCCGCATCGACTTTCCGGATCACATCCCCGGGCCGGACACC
+GATGCCGGCGAGGGATGACTGCGGATCGATTTCGGAAATAATGACACCCTTGTCCGCGTT
+TATGGTTTGATTGAAACGGACCTTCTGCCCGATACCGACGACCTTGACCCCCAGCAGTCT
+TTGAACCAGTTCCGGCGCAAGCGATTCGGGGAACACCTCGATCCTGACCGAAAGGGTCAG
+GTGCCTGCCGTTCCGGTCGATCTTCACAACCGCATGCTGCCCTTTCCGATATCCCCGCAT
+GGCGGTCTTGTAATCGTCAATCGATTCGATTTTGTGGCCGTCGATGGCCAGCAGGATATC
+CCCTTCCCGTATGCCGGCGGCTCCGGCCGGACTCGACGGATCGACCGAACGGACGACGAC
+GCCGGAATGCTGCGGCAGATTGAGATAGGCGGCAAGCCGGGAATTGAGGTTCTGAACCGA
+CAGGCCGATCCAGCCGGGGACGACCTCGCCGTATTTGATCAGATCAGAGATGATCTTTTT
+CGCGCGGTTGATGGGGATGGCAAATCCGATCCCCTCGGCATTCTTGTAAATGGCCGTGTT
+GATGCCGATCAGCTGACCGTCGATGTTCAGCAGCGGCCCGCCGCTGTTTCCCGGATTGAT
+CGAGGCATCGGTCTGGATGAGATCACGATAAATCCGGTTCTTAATCCGGAAACTCCGGTC
+GACGGCGCTGACAACGCCGACGGTGACGGTATTTGAAAAACCGAACGGATTGCCGATGGC
+GATGACGGTCTCCCCGATCATCAAATCGGATGAATTGCCCATTGCGATGGACGGAAGCGG
+GGATTTGGTCTTGATCTTCAACACGGCGAGATCCGATTCCGGATCGATTCCGACAATGTC
+GGCATGGAACTTACGGCCGTCTTTCAATACCACCGTAATCTTGGCCCCCCGGACAACCAC
+ATGTGCGTTGGTCAGGATAAATCCGCGCCTGCCATCGATGATCACGCCGGATCCCAGGCT
+GGTCAGCTTTTCCTTGCGCTCGATGCCCTGATCGAAAAAATTATTGAAAAAATCGTTTGC
+CCCGAAGTTGGCAAAAGGATTCACCCGGGTCCGGACTTCATACTGGGTGCTGATATTGAC
+GACCGCGGGGCTGACCAGCTTGACGGCCCGGACGACGGCATCTTCACGCGGATAGTGCAG
+GACTTTGGGCCCCCCGGTTTTGGCGAACACGGCCGGGGAAAAGCAGAAAACGATACATCC
+GATGACAAGAAACAGGTGAATTTTTTTACGCATACGGGTCCCGATATTTCTGTTGATTAT
+CAAATGGGGTCATGATATTAAATTTTAACATCGTCGCTCCATTCCATAATATAAAATTTG
+AGGAATTGAAAGCGTAAACATGTTCCAGTTTCTATTGTTTGTCGGAAGTATCACAGCCTT
+TATCATCGGAGGGCTGATCGTTCTGATCGGGATCGGCGCCATTACCGGTTGTGCCGGGGG
+AATACTGGCAATGTGCAGCGGCGCCATCATCGCGGTTCTCGGCGCATGGTCCGCCATCAC
+CTTTTTTCTTCCCTCGCCCGACCCCAGTGTTCCCGCCCGGGAAACGATCAATCTGATCCG
+CCGAAACGGCCGGTGGATGTAACCGCGTACCGGTGAATTCCGAAAAGGCGCCCCCGCCCC
+TCCCCTGACGGGATACGACGGACCGGTATCCACCGGATCCGGCGCTAGTTCTTTCTCCTG
+ATTTCACGCTCCAGCGACTGAACCTTCAGGGAAAGCGATTCAACCTGGTCGATCAGCTCC
+TTTACCTGTTCCTTTGAGGCGAGATTCATCATATTGAGGGCCTCGTTGACGCGCTGATCG
+ATATTTTCCCTTATCCATGTTTTCAGGCCGTTGGTATAAGCGGTAATTTCCTTTTTGAGC
+GTCCGGCCTTCGGTTTCGGAAAGTTCCTTGTCCTTGACCAGTGTGTTGATCAGCTTTTCG
+TTTTCATCCCTGGACATGAGGACCGCACTCTGCCACAGGGAGATATATTTTTTGCCGTAG
+CCGAACAGTGTCCCGCGACCCTTCCGCAGCATCTGCATCAGAACGCTCGACGGCAGCGCC
+GTATCGTCTTCATTCTTTTCGCGGGCCAGAAGCTGCGAGACCACCTGGGCCGTCAGGTCA
+TCGCCCGTTTCGTTGTCGATAATCATGACCTCGCTTCCGGACTTGATCAATTCGGCGAGT
+TTTTCCATGGTGATATACTGTTTATCGGTCGTATCATACAATTTGCGATTGGCATATTTT
+TTGACGAGATGCATGTCCCCTCCTGAAAGTTCAACAATATAATGCTGCTTTAATATGACG
+CATTGCGTTATCCTTGTCAAGGGATTTGCCGCCGTTGCACCAACTGACAGAATACATTGA
+AATGTTTAAATAATCCAATGTATCGCATCAAACAAAGCAGACACCGCGTTGTCCGTATGC
+GACGAAAGGGATACCCTTATCTTATTGCTGGAAATAAAAAAAATAAGAGATTGAAGAGAT
+GAAGGGAAAAAGCAGAGAGCGCCGGCATCAAGGACCTCCGGTTCAGGTATGCAGTAGACG
+AAAAAAGGCATATGCCGCCGTCCGGAAAAGCCAGAAGAAAAAAGCGGACAAATCGAAAAT
+CCCCGCTTCCGGAGATCATCGGCACTGCGACGCAATGATATATTTTTACATTGCATTCGG
+CCTTCGGATCTGTTAATTGTAGTTTAAAAGTCACATCTGAACCACAATCCTTGCACAGTT
+CAAATCCAGTTGCCATATTTAAGATATGGACGGGTACCCCGCATGATTGAAGGATACAGG
+CGGGGAGTGGTATTTTATTTTCCCAAGGAGGCGCTACGATGAGAAAACAGGTTGAAATCA
+TGTCCAGTATCGACAATTTCTGGCTCTACATGGATCATCCCACCAACCTCATGATTATCA
+CCGGATTTCTCCAGTTCGACAAGCCGATCAATTTTGAGCGTTTGAAACAGACCATCAAAA
+ACCGGCTTCTCTGTTATGATCGCTTCAAAAAAAGGGTGATCCGGCCGATGACCGGTGTGG
+GAAATGCAACGTGGGAACTCGATCCCAGGTTCGATCTCCGCTCCCACCTGCATCGCGTCG
+CGCTTCCCGCGCCCGGTGACAAAGAGACGCTCCAGGAACTGATCAGCGACCTGACCGCCA
+CCCCGCTGGACCCCACAAAACCGCTGTGGCAGCTGCATTATATCGAAAACTGTGAAAACG
+GCGGATCGGTTCTGTTCGCCCGCATCCACCATTGCATCGGTGACGGCATCTCATTGATCC
+GGCTGCTGCTGTCCCTGACCGACACCGAACCGAACGCGGTCTGGAGTGATTGCTTAAATG
+AGCCGAAGATCGAAAAGGAAACCAGCTTCAACCTGTTTCCGCCGCTGGAATCGGCGATGA
+AGAAGGTCACCCGCGCCAGGAGACGGGCCCAGAAAGTGACGCGGTTCGTGAGCCGGGAAA
+TCGAAAAAAGCTTTTCGAATCCCTACCACATCGTCAAGCGGACCCGAACCGTTACCAAAT
+TCGCCCTGGATGTCGCAACCGTCATGAGCAAGATCCTCCTGCTGCCCGCCGACCGGAAAA
+CCGTTTTCAAGGGGGAACTGGGCGTGCGGAAAAGCGTGGCATGGTCCGACCCGCTCCCCC
+TGGACGACATCAAGGTGATCGGCAAATATTTCAACGCCACGATCAATGATATCCTGGTCG
+CTCTCGTGACCGGGGCGCTTCGCCGGTATCTGCAGCAGTGCAATAATCTGGTGGGAGACC
+TCGACATCCGGGTGGCCATGCCGATCAACATCCGCCCGATAGACGGGGACATCGAACTCG
+GCAATCAGTTCAGCCTGATACTGGTCGCCCTGCCGGTGCATATCGATGATCCGGTCCTCC
+GTATCCGGGAAGTGCAGCGCCGGATCAACGATCTCAAGGAAGCGCCGGATGCCGCCGTGG
+CCTACGCGGTCCTGAATGCCCTCGGGGTGTCGTCCGCCAAACTGGCCAAAACAGCGGCCA
+CCATGTTCGCCAACAAAACCACCGGCGTGTTCAGCAACGTACCCGGCCCCCGGCAGCAGC
+TCTATTTCTGCGGGGAAAAGATCAACAATATCATGTTCTGGGTCCCCCGCATCGGCGGAC
+TGGGGATCGGGATCAGCATCATCAGCTACAACAATGAGGTTTCACTCGGTATTGCGACGG
+ATTCCGGACTCGTGCAGGACCCCAAAGCGATTCTGGACCATTTCGCGAACGAATTTCGGA
+TGCTTCTGGGGATGTACAAAGCCGGACAGATGGAAAAGGAACCCCTGGTCATCAACGACC
+GGTCCGTGGAACCGCCCGTTTTCGCCTTTAACACGGAAAAAATCGCCAGCGTTCAGGCCA
+TCCGCTGCAAGGCCATCACCCGGAGCGGCACCCAGTGCCACAATCGCGCCGCCACCAATT
+CCATGTACTGCACCCTGCATCTGTCAAAGTATGAAACCATCGCCAGCAGAGAAGAAAATG
+ACATGCCGGCAGAGGCCGACAACACCCTGCCGGCCGAAGACCAGGCCGCCGGATAAATCC
+GGAAGATCAGGCGGGTTGATGAAAAATTTCAAGATTTGAAAACGCAAAAGAGGGGATCTG
+ATCGGATCCCCTCTTTTTTTATGGCAAGGATTAAATCTTAAATTCCGGATGTTTCATGAG
+CTGTGTACTGATGACCCGAAGCCCTGAAATATCATTGACGGTTTCATCGGCAAAGAGGAT
+CGGGAATACGGCCAAGCCGGGACTGATGGATGAAATGCGGTCGATGGCCGCGGCATCGCT
+TCGGGCGAGTTTCCGGTCCATGCGGTCGGCGATTTCCAGACGCTGAAAAATAGGTTTATC
+GGCTATTTTTTCCATCAGGACGCGCTTCCGGTCCGCCGCTTCCGAATCGAACGGCGAATC
+GGCCGTGTCGGAATGGACCCGGTTGACGATGAACCCGCCGAAAGGCATATTCCGCTGCTG
+CAGTTGCCGAAAGAGATAGGTCGCCTCCTGAATCGGATATTCCTGCGGGGTCGTGACAGC
+GAAAAAAGTCGTCATCGGATCGGACAGCAATGATTCGACCGCCGACGCCCGTTTGCTGAA
+ACCGTCAAACAGCATATCGTTGAAGAGCTGGAAAAAAGAAAAGATATCCGATATCGTCTG
+CCCGCCGACGACCTGCCCTACAGCGCGCAGCACCGGCATGGCCAGGAGATTGAAAAGGCG
+CCCGCTCAGTTGACCGGCCTTGATATACGGCTTGAACAGTTTTAGAAAGTACGGGTGTCC
+CAGAAGGTTGATGACCCGCTGGGGGGCTTCCAGAAAATCGAGGGCGCGACGGCTCGGCGG
+CGTATCTAGAACAATCAGATCGAACCGCTTTTCATGGTAGATCTCGTAAAGCCGCTCCAT
+GGCCATATATTCGTGGGAACCGGCCATATTATTGGACACGTGCTGGTAGTAGCGGTTTTC
+CAGAATCCGGTCGCGCAGTCCGGCTGATGAATACCGGCCGATCAGACGGTCGAAGGTCCG
+TTTGGCATCCACCATCATGGCATACAACTCACCGGAGGCAGGTACCGATGCCTCCAGCGG
+AACCCGCTGCGCCTCCATGTTCAGGGCCGATATGCCGAGTGCATCGGCCAGCCGCCGGGC
+CGGATCGATGGTGAGCACCACGGTTTTTTTGCCCATCAAAGCGCCGCATAAGCCGATAGC
+GGCGGAAATCGTCGTCTTTCCGACGCCGCCGCTGCCACAGCAGACGACAATCCTGGGATT
+GTTCGGTGTCGGCGCCGGAGCGTTCATCGCCCGCCTCCACGGGGAGCTTCGGATATCTGA
+CGATGCAGCGACGCGGCAATCGTGCGGATCTCCTCCGGCCCCAGATCATTTGTATAATAG
+TAAGGGACATGGATCACGTGACCGGGAGCGGCCGCGTGAACCTCGTTCATCTGGACCTGC
+TGGGCGGCATTGCGGACGATCTGCCGCCGGGCGACATCAAGCGCGAACCGCAGATCCGGA
+CAATCCGGATCTGCATCGGGACAATCCCGGTCAAGCTCCTGGATCCGGGAGAATTCATCG
+GGTGTGACAAACACCGGGTGTACGCCGTTAATGAATACCGCCTGAACGGGAATCCCCACC
+TCATCGACGGCAATGTCGATCATTTCACGGGTCTCATTGACGGGTAATTCTTCGGGAAGG
+GTCACGAGGGTCAGGGCCGTGCGCTCCGGGTTCAAGAGCATCTGCTGGACCCCGTTGACC
+TGGGATGCGATCGGTCCCACCCGGATCATCTCCACGAGCATTTTCGGCAGCCGAAGCAGG
+CTCAACCCGTGGCCGGTCGCCGGCGCATCAACGATGATAGTGTCATAAAGCGGCGTGCCG
+GCCTTGTTCTTCGCCTTTTCCCATCGCCAGATCCGGGCCAGCGTCATGATCTCCTTGAGA
+CCGGGAGTGGCGGCCAGCAGGTAGTCGAAAAGCCGGCTCTGGGTGATGCGGTTGGCGATA
+AAACCGGACTTCATGTGGTAATGAAGGTAGGCCGTCAGTTCATCTTTCGGATCAACACGG
+GCAGCCCAGATGGCCGATGAGACCTGCCGGGGACGGACATCGGGCTGTGCATCGAAATAG
+CGGCCGATGCCCTGGCTGTCGCCGATTTCGGTCAACAGCACCCGCTTGCCCATCATTTCG
+GCCGTCAATGCGAGAGCAACAGACAGGGTGGTCTTGCCCACCCCCCCCTTGCCCATCAAA
+AAGATCAACCGACGGGTCAGCAGTTCGTCGAGTGAGCGCACGCCGGCGCCGATCGAAAAC
+AACGCCTCAAGTTGTGTCCGGTCAGATTCATCCGCTTTTGCCATGGCATGTTCCCGAAGA
+CACAATAATCATTTACAGTGCCGGGTGAAGCGCGCAACACCCTGTAATGGCCCGGGCGGG
+CGATGCCGCATCACGAAGTTTTTTTGGTTTTAGCGGGCCCTTTTTTTTCTTTTCCCAATC
+GATTGATTCGTTTGTTCAGTTCCTCGATTTTTCCGGTCAGCTCAAGGATCTGATCCCGGT
+TGGCGAGGTTCATCCGGTTGAGCACCTCGTTGACCCGGTTGTCGATGTTGCGGGTGATCC
+ATCCCTGGATATTGGTGCGATAGCGGTCAATCTCCTTTTTGAGCTTGCTGCCCTCGAGCT
+CGGTGAGCTTGTTGTCCTTGACCAGCATATTGACCAGTTTATCGACCTCGTCTCTGGACA
+TGGTCACCATGTTCTGCCACATCGAGGCATACCGTTTTCCGTAATCGAACAGGGCGTCGC
+CACCTTTTCGAAAGAGCTGTACCAGCATACCGGTCGAATCGTCAACCGCTTTGTTACTTT
+TTCCGGCCTTTTTGGATTTTGACGGATTCTGTTTTTTGGCTTTGATCCGGGAAACGATGT
+CGTCGGTGATATCCTTCTCGGTCCGGGTATCGATAATCGAGATTTTTTTACCGGCGCCGA
+GAAGCTTTGAGATCTGCTCCCGGGTCACATAGTTTTTTTCCACCGTGTCATAAAACCGGC
+CATTGGCGTAGCGCTTAATCTGGTACATAACTCCCTCCTGTGTTTGATGGCAGCCCCTTT
+ACGGAGCCTGTGTGGAAATGGTCAGAGACATACCTTTTCGGCACGGGAGAAGATCAATCG
+GAGATGGATGTAAGGGAATGTCCTGCCTGACTGTATGTCGTTTCGGAAGAAATACCGGGC
+GATTCACGTTCAATCCGCAAATCGCCCGGTACCGGTGTTGCTTTTGTTCGAATTACTGGG
+CGCTCTGCTTTCTCAATGCTTCAATATTGGAATTCAAGGCTTCCATTGCCAGCGTCAGTT
+TCTCGATGTCGCCCTTGCCGGGCAGATTGACCACCGAAGGAACGGAATTCAAACTGGAGG
+TCACCTTCTTTTCGACCGTTTCGACCAGGGGGAGCTTGTACATGAACTTTTTGCCGTTTT
+CGACATAACCGTCCATCTTCTTCCAGGCGTCTTTTTCAAAGGACCGGCCTTTTTCAAGCC
+ACTGATCCATGGTGCCGGAAAGCTTCTTGTAGGGTCCGTCGACATATGATCTGCCTTTTT
+CAACGGCCTTTGTGATATATTTGTCGTTGTATTCCTTAAGGGTATCTTTGCCCTTTTCAA
+CGGTTTTTACCAGATATTTTTCATTGTATTCTTTCAGGGTCGCCTTTCCTTTTTCGATAT
+TTTTGGCGACGTATTTTTCATTGTAGCCTTTTACTTTATCCGTCACCGATTCGGCGGCCT
+TCTGAATTTTTCCGGTGATCTTGGTCTGGGCGGTTTCGCCCTTTTTGGTTGCGGTCTTTG
+CCATGGTACGGTCCTCCTTGGTTAAATTTGATTTCACATCCTGTTCATATCCGGGTCATC
+AGAAAAATGGTATATATGGAAAACGCAAAACTGCGATCAGAAAGAATCGGCAACCGGTTA
+TATTGCATTGCGTCATGACTGAAGAATATGACGCAATGCGTCATATGTCAAGAAAAAAAA
+TCTCCGCGCAGCTGAAATTTGAAACGAAATCCGGATAACGCATTGCGTTATCTACTTGTG
+ACGCATTGCGTTATTTTTGTCAAGCTTTTTTCCCCTCAAAATCCGTCCGATTCCCTTAAA
+CCCGGGATGAGGCGAATACCCCATGCCCCTCATCCCGCACAATCGATCTGCACGATATGA
+TTTTCCATGTTGCGATTTTATCAAACCGGATCTATTTTAGTTGTAAAGCAGGAAGCGAAA
+CCAGATTGAAGACAAAAGAGGGGACCAAACCCCTCCTCAAGCGGAGCAGATAATGGGCAA
+AACCATTCGACGGGCGCTTGTGCTGTCCGGTGGCGGAGCGCGGGGCGCCTTTGAAGTCGG
+TGTGATGCGGTACCTGAATGAAGTGAACTGGCAGCCGGATCTGATCTGCGGCACGTCGAT
+CGGCGCGATAAACGGCGCGGCCTTCGGTTCCGGCATGTCGGTGGATGAGCTGGCTCACCT
+CTGGAAAACATACCACCGCAAACAGATGTATAAGATCACCTTTCCGGCATTTTTCCGCAC
+CCTGTTGAGCGGCCGCAAATTCTCCCCTCTATCGGATAACCGGCCGACACGGTCCCTGCT
+GGAAAAGACCATCGACATCGACGCCTTGAGGAACAGCACCACTGAAATTATCATTTCCGT
+CCTGAATATGCGGACATCACAGGTTCGTTATTTCACCCACAAAGCGATCGGTATCGAGCA
+TCTCATGGCGGCCGGCGGGATTCCCATGATGTTCCCGTGGCAGTACATAGACGGGGATCC
+TTACTGGGATGCCGGCGTCATGGTCAATACGCCGATCATGCCCGCGTTTGAACGGGGAGC
+GACGGAAATCATCGTGGTGCTGCTGTCGCCCCTCGGCGCCATTCCCCAGCGTCTGCCCAG
+CACCCATCGGGAAGTGAGCGAGCTGGTGTTCGAACAGTTTTTGATCGGTTCGTATACCGC
+CTGCCTGCCCAATGCCGGATGGCGGACGAATCCGGAGGCGGACGTCTACGATACGCCCCT
+GCCGGACTCCCCCCAGCTTCAGCTTTCGATGAAAGGCGTCCGGATGGCGACCGTATATCC
+GACCCGGATGCTTGGATTTCGCTCTTTGCTTGACTTTTCTCCCCGGCAGGCCAAAACCCT
+GCTCCGGGATGGTTATGTCAATGCGCGCATGCAATTGAAGTCTTTTTTTAAATAAGACGG
+GATATTGCAGAAACGAGCGCGACCGGATTGACATCAAAGTGGCATTAAAATCCGAAAATC
+ATCAGCAAAAGGAGAAAAAAATGCCGACAGCAACGATCCGACAGCAACTGATCGAACTTT
+TGAGCGAAAACAAATATGATGCCCGGGACCTGTCCCAGCGTCTGGGCGTCCGTGAAACCG
+TCGTATACGACAGCATCCCCCATATCACCCGGTCCGTGACATCCATGGGCAAAAAACTGA
+AAATCGTTCCATCACGCTGCACGTCGTGCGGATATACGTTCAAGGACCGCAAACGCGCGG
+CAAAACCCAGCCGATGCCCGACCTGCAAGAGTGAGCGGATCGCAAAGCCGAAGTTTTATA
+TCGTCTGACCGGAAAAGTCCCGTCAGCCGGTAACGACCGCTTCCAGTTCGGCAAGGGAGA
+TGGAATCGACAAATGCGGCCCCGATGGCGGAAAGCAGGACGAAATGGATCTTTTCCCCCT
+GGCGCTTTTTATCCCGGGCCATGGCGTCGATGATGCGCTCCGGATCGATGGGGAGCGCGG
+TCGGCAGGTCCAGGTGCGTGAGCAGATCCTTTAACCGCCGGATGTCCGGGCGGGGGAGAT
+GCCCCCGGTTTGCGGACAACTCCGCCGCCATGACCATTCCGGCGCTCACCGCCTCGCCGT
+GCGGCACACCGAGGGTTTTCTCGATGGCATGGCCGAGGGTGTGCCCGAAATTCAGCTTTC
+GGCGCTCTCCCCGCTCCTTTTCGTCGGCGTTGACCACCCCGGCCTTGATCACGACCGATT
+TGCGGATGATCCGCTCCAGCGTTTCCGGGTCCCGGGCGCACGCCTTTTCGTGGCTTTCTT
+CCAGATCGGCAAAGTAATCTTTGTCGGAAATGGCGGCGTGTTTGACGATTTCGGCAAAAC
+CGCAGGCCAGCTCCCTGGGCGGAAGCGTACCGAGCACATACGGATCGCAGATGACGAACT
+CGGGCTGGTTGAAGACTCCGACCATGTTCTTGTAGCCCATGAAATTCACGCCGTTTTTCC
+CGCCCACACTGGCGTCCACCTGGGCCAGGAGCGTGGTGGCCACATAGCCGAACCGCACCC
+CCCGCATGTAGGTCGAGGCGATAAAGCCGGTGATGTCGCAGACGATGCCGCCGCCGATGC
+CGACGATAAACACCGACCGGTCCGCAGCCATTGAAACGAGCCGCTCATAAATCATCTTCG
+CGGTATCGAGCGTCTTGATCGATTCGCCGCACCCGATGGTAATGACCTCGACGTCGGGAA
+ACATTTTGCCGTAATGGCCGGCCACATTCGTGTCCGTGATCACCACGATCCGGCGATCCG
+GAAGGTAGTTAGACAGGTTTTCCAGTCGCTCGCCGATGACGATTTTCGATGCACCGGTCT
+GGCCGCTGATTGAAACGGTTTTCACAGGTATTCTCTCCAATAAGGAATATCAACGGGTTT
+CATCGGTTTCGCCGAGTATCCGGAAAATGGACCGGACCTGGCGGCACAACGTTTCGAACT
+GATCGGGGTACAACGACTGCGATCCGTCGCACTGGGCGGTATCCGGGGCATTATGGACTT
+CGATCATCAATCCGTGGGCCCGTGCCGCCGCCGCCGCCCGGCTCAGGGGAATCACCTGGT
+CCCGGAATCCGGTGGCATGACTGGGATCGACGATGATCGGCAGATGGCTTTCCCGCTGCA
+CCACCGGAATGGCCGACAGGTCCAGCGTATTGCGACTGTGCCGGACAAACGTGCGGACCC
+CCCGTTCACACAGGATGATGTTCGGATTCCCCTGCGACAATACATATTCCGCCGCCATCA
+GCCATTCGTCGATGGTGGCGGACATCCCGCGCTTTAAAAGAATCGGCTTTTTCGATTCGC
+CCGCCCGCCTGAGCAGGCTGAAATTCTGCATGTTGCGGGTACCGATCTGAACGATATCGG
+CATACGCTTCGACCATGTCGAAATATTCCAGATCCATTACCTCGGTCACGATCGGCATCC
+CGAACTGCTCCCGGGCCCTGGCAAGGATCTTGAGCCCTTCCTCGCCGAGTCCCTGGAACG
+CATAGGGAGAGGTCCGGGGTTTGAAGGCCCCGCCCCGGAAAATGTCGGCGCCCGCTTTCT
+TGACCCGTTCGGCGGTGGCCATGACCTGCGCTTCGCTTTCCACCGCGCACGGCCCGCCGA
+TGATGACCAGATGACCGTTTCCGATTTCGACGCCACCGACCCGGATAATGGTGTCATGCG
+GCTGAATCTCCCGGCTGACGAGTTTATAGGGACGTGTCACCGGAATCGTCTCCTTGACAC
+CGGGCATATCCTGGAACCAGGCCGCATCGATCGCCGTGCGATTGTTTAAAATTCCGATCG
+ATACCCGGTCCCCGCCCGGTATGGAGCGGGCCGTATATCCCCTGGCCTCGATCGCCCGGA
+TCACAGCATCAATCTGTTCCCGGCTGGCATCCTGACGCATCACGATGAGCATGGTCTCTC
+CTCCTGCAAAATCATTGTCGAATGGGTCATCCTTTAAAATAAAAAACCGTGGGGTCCTCG
+CGGGGCCCCACGGTCTCAGATACTTTTCGATACCTCAAAAACGGATCAATCCGGTATCGG
+CCGAAGGGAAAACCCCGCTGATACGGGCTTTCGCCATCCGCGCCAGAATCCGTAAATCAA
+TACTGCAAATCCATATTGTGGCATTTTAAAAACCGCCCGATTGAACCGGTTTGAATCATT
+TGGCAATTTTACATCAATTTTTATTTCAATAGGCCTTTATACGCGGCATCGTCAAGAAAA
+ATATTGTTTACTCTGGCGATTCATGGCCGACACATCAGAAAAATATGCGACAAGGTACGA
+AAATGATTCTGATTGACATTTTGCGGCGAAACTGGTATGACCTCTTACCATTGAATGAGA
+TCGGCAATATCTGCGCGGTAAAATTTGGCAACAAGGCGGCGGATCCATGACGAATGCGAC
+AAACGACCAGCCGTTTCGACCGGCCCGGTTCACCGAACAGCGGCTGATCACGGCCATTCT
+GGACGGCACCTGCCCGCCGGGGTCCGTGCTGCCGGCTGAACGCCGGCTCGCCGAACAGTT
+CGGGGTCACCCGCCCCACTATCCGGGAAACCCTGCAGCGGCTTGCGGCCGAAGGGTGGAT
+CACGATCCGCCACGGGAAACCGACCCGGGTCAACGACTTCTGGGAAACCGGCGGGTGTTC
+CTAGGCTGTTTCCTGGTGGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTTGAGTAT
+TCTATAGTCTC
diff -r 000000000000 -r 68a3648c7d91 filter_Fb/filter.fb.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/filter_Fb/filter.fb.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,22 @@
+#!/usr/bin/perl -w
+#
+$f=shift;
+$out=shift;
+open(IN,$f);
+open(OUT,">$out");
+	while(<IN>)
+	{
+		if ($_=~/^#/)
+		{
+			print OUT;
+			next;
+		}else{
+			$vl=(split())[5];
+			$gt=(split())[-1];
+			$gt=(split(/\:/,$gt))[0];
+			next unless $gt eq "1/1";
+			print OUT  if $vl>20;
+		}
+	}
+	close(OUT);
+
diff -r 000000000000 -r 68a3648c7d91 filter_Fb/filter.fb.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/filter_Fb/filter.fb.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,13 @@
+<tool id="filter_FB" name="filter_FB" version="0.">
+ <description>filter low quality variants from vcf file"</description>
+  <command> /home/inmare/galaxy/tools/filter_Fb/filter.fb.pl $f1 $o1 </command>
+   <inputs>
+   	<param name="f1" type="data" format="vcf" label="unfiltered vcf" help="vcf only"/>
+   </inputs>
+   <outputs>
+   	<data name="o1" type="data" format="vcf" label="filtered vcf"/>
+   </outputs>
+   
+   <test/>
+   <help/>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/4mers.list
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/4mers.list	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,256 @@
+AAAA
+AAAC
+AAAG
+AAAT
+AACA
+AACC
+AACG
+AACT
+AAGA
+AAGC
+AAGG
+AAGT
+AATA
+AATC
+AATG
+AATT
+ACAA
+ACAC
+ACAG
+ACAT
+ACCA
+ACCC
+ACCG
+ACCT
+ACGA
+ACGC
+ACGG
+ACGT
+ACTA
+ACTC
+ACTG
+ACTT
+AGAA
+AGAC
+AGAG
+AGAT
+AGCA
+AGCC
+AGCG
+AGCT
+AGGA
+AGGC
+AGGG
+AGGT
+AGTA
+AGTC
+AGTG
+AGTT
+ATAA
+ATAC
+ATAG
+ATAT
+ATCA
+ATCC
+ATCG
+ATCT
+ATGA
+ATGC
+ATGG
+ATGT
+ATTA
+ATTC
+ATTG
+ATTT
+CAAA
+CAAC
+CAAG
+CAAT
+CACA
+CACC
+CACG
+CACT
+CAGA
+CAGC
+CAGG
+CAGT
+CATA
+CATC
+CATG
+CATT
+CCAA
+CCAC
+CCAG
+CCAT
+CCCA
+CCCC
+CCCG
+CCCT
+CCGA
+CCGC
+CCGG
+CCGT
+CCTA
+CCTC
+CCTG
+CCTT
+CGAA
+CGAC
+CGAG
+CGAT
+CGCA
+CGCC
+CGCG
+CGCT
+CGGA
+CGGC
+CGGG
+CGGT
+CGTA
+CGTC
+CGTG
+CGTT
+CTAA
+CTAC
+CTAG
+CTAT
+CTCA
+CTCC
+CTCG
+CTCT
+CTGA
+CTGC
+CTGG
+CTGT
+CTTA
+CTTC
+CTTG
+CTTT
+GAAA
+GAAC
+GAAG
+GAAT
+GACA
+GACC
+GACG
+GACT
+GAGA
+GAGC
+GAGG
+GAGT
+GATA
+GATC
+GATG
+GATT
+GCAA
+GCAC
+GCAG
+GCAT
+GCCA
+GCCC
+GCCG
+GCCT
+GCGA
+GCGC
+GCGG
+GCGT
+GCTA
+GCTC
+GCTG
+GCTT
+GGAA
+GGAC
+GGAG
+GGAT
+GGCA
+GGCC
+GGCG
+GGCT
+GGGA
+GGGC
+GGGG
+GGGT
+GGTA
+GGTC
+GGTG
+GGTT
+GTAA
+GTAC
+GTAG
+GTAT
+GTCA
+GTCC
+GTCG
+GTCT
+GTGA
+GTGC
+GTGG
+GTGT
+GTTA
+GTTC
+GTTG
+GTTT
+TAAA
+TAAC
+TAAG
+TAAT
+TACA
+TACC
+TACG
+TACT
+TAGA
+TAGC
+TAGG
+TAGT
+TATA
+TATC
+TATG
+TATT
+TCAA
+TCAC
+TCAG
+TCAT
+TCCA
+TCCC
+TCCG
+TCCT
+TCGA
+TCGC
+TCGG
+TCGT
+TCTA
+TCTC
+TCTG
+TCTT
+TGAA
+TGAC
+TGAG
+TGAT
+TGCA
+TGCC
+TGCG
+TGCT
+TGGA
+TGGC
+TGGG
+TGGT
+TGTA
+TGTC
+TGTG
+TGTT
+TTAA
+TTAC
+TTAG
+TTAT
+TTCA
+TTCC
+TTCG
+TTCT
+TTGA
+TTGC
+TTGG
+TTGT
+TTTA
+TTTC
+TTTG
+TTTT
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/clusterF.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/clusterF.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,19 @@
+<tool id="cluster" name="FosBin" version="0.">
+ <command> /home/inmare/galaxy/tools/fosm_cluster $f1 $l $o1 $o2 </command>
+ <description> k-means clustering of assembled fosmids.</description>
+ <help>The tool was designed to tentatively assign contigs from incomplete fosmid assemblies to clusters, ideally corresponding to single fosmids. Clustering is performed based on tetra-nucleotide frequencies of the contigs and coverage. The current version is only compatible with SPAdes output as coverage is recovered from the fasta headers. Future version migth require a different set of input files. Full details are in Chiara et al. #paper id. Clustering of contigs is performed by a custom script based on the R implementation of the K-means algorithm, using 1500 starting positions for the centroids. The clustering is performed on metrics based on coverage, GC composition and tetra-nucleotide composition of each contig, which are computed directly from the fasta file. The user must input the desired number of clusters, contigs are partitioned accordingly." </help>
+ <inputs>
+ 	<param name="f1" type="data" format="fasta" label="fasta file with contigs" help="currently need to be in SPAdes format"/>
+ 	<param name="l" type="integer" label="number of clusters" value="5"  help="should correspond to the number of fosmids"/>
+ </inputs>
+ <outputs>
+ 	<data name="o1" ftype="tabular" format="txt" label="fosmids to cluster table"/>
+	<data name="o2" ftype="fasta" format="fasta" label="modified fasta file, containing cluster identifiers in the header"/>
+ </outputs>
+  <test>
+        <param  name="f1" value="sim1_galaxy.fasta"/>
+        <param  name="l" value="9" />
+        <o1 name="outfile1" value="res"/>
+	<o2 name="outfile2" value="fasta.fas"/>
+ </test>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/compute.stats.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/compute.stats.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,81 @@
+#!/usr/bin/perl -w
+$file=shift;
+$ncluster=shift;
+$ofile=shift;
+$fasfile=shift;
+$flist="4mers.list";
+open(IN,$flist);
+while(<IN>)
+{
+        chomp;
+        push (@let,$_);
+}
+close(IN);
+open(OUT,">$file.stats");
+open(IN,$file);
+%c=();
+$name=(split(/\./,$file))[0];
+while(<IN>)
+{
+	chomp;
+	if ($_=~/^>(.*)/)
+	{
+		$id=$1;
+		$M{$id}=$name;
+	}else{
+		$c{$id}.=$_;
+	}
+}
+close(IN);
+foreach $s (keys %c)
+{
+	($len,$cov)=(split(/\_/,$s))[3,5];
+	$seq=$c{$s};
+        $at=0;
+        $gc=0;
+        $le=length($seq);
+        $tt=0;
+        %DD=();
+	@seq=(split('',$c{$s}));
+
+        foreach $l (@seq)
+        {
+                if ($l eq "A" || $l eq "T")
+                {
+                        $at++;
+                }else{
+                        $gc++
+                }
+        }
+        for ($i=0;$i<=length($seq)-4;$i++)
+        {
+                $subs=substr($seq,$i,4);
+                $rc=reverse($subs);
+                $rc=~tr/ACGT/TGCA/;
+                $tt+=2;
+                $DD{$subs}++;
+                $DD{$rc}++;
+        }
+        $gc=$gc/$le;
+        next unless $len > 1000;
+        print OUT "$s\t$gc\t$cov\t";
+	foreach $L (sort @let)
+        {
+                $val=$DD{$L} ? $DD{$L}/$tt : 0;
+                print OUT "$val\t";
+        }
+        print OUT "$M{$s}\n";
+}
+
+system("./kmeans.R $file.stats $ncluster $ofile ")==0||die("no kmeans");
+
+open(OF,$ofile);
+$l=<OF>;
+open(FAS,">$fasfile");
+while(<OF>)
+{
+	($id,$cluster)=(split())[0,1];
+	$NC{$cluster}++;
+	$id=~s/\"//g;
+	print FAS ">$cluster\_$NC{$cluster}\#$id\n$c{$id}\n";		
+}
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/kmeans.R
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/kmeans.R	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,11 @@
+#!/usr/bin/env Rscript
+args = commandArgs(trailingOnly=TRUE);
+data<-read.table(args[1],sep="\t",row.names=1);
+data<-data[,1:258];
+data[,2]<-data[,2]/sum(data[,2])
+file<-(args[3])
+num=as.integer(args[2])
+K<-kmeans(data,num,nstart=1500)
+clust=K$cluster
+
+write.table(clust,file);
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/res.fasta
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/res.fasta	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,38 @@
+>9_1#NODE_2_length_40000_cov_63.1617_ID_3
+CCAGCGGCCAGGTCGATCGACAGCACGCACTGCCCGGTGTAGGGCAACAGGCGCTCGCGGTCGTCCAGGCTGCCCGCGCAGGGCTTGACCACCATGACATCGTTGGCACCGGTTTCCAGCAGATGGTCGATCACGCCGAGCAACTGCCCGCCCTGGTCGATCACCTTCAGGCCTTCCAGCTGGTGCCAGTAGTACTCACCTTCCTCGAGAGAGGGCAACTCGCTACGCGGGATGCAGATCTCGTAACCGGTGAAGGTGCGGGCCTCTTCGCGATCGTCGAGCCCCTTGAGCTTGGCGGCCAGGACCTTGCCATGCAGGCGCCCCCTGACCAGCTCGGCCTGCCGAATCTCGCCGTCGCGCCGGAGCGTCCAGCGGCGATAGTCCAGCAGGTTGTCCAACGGGTCGGTAAAGGAATACACCTTCACCTCACCGCGGATGCCGTACACCGAAACGATCTTGCCGATCACGACCAGGTCGTCGGCGGGTGTCGGCATTTCACTCATGACGGCTTAGGCGTTTGCCTTGGCAGCGTCCTTGAGCAGCTGAGCAACGCGCTCAGACGGCTGTGCACCCTGGCCGAGCCAGTAGGTAGCACGCTCCTGGTCGACGGACAGACGCACTTCGCCACCAGTCGCAACCGGGTTGAAGAAACCGATGCGCTCGACGAAGCGACCATCGCGCGCATTGCGGCTGTTGGTCACGGTCAGGTGGTAGAAGGGGCGCTTTTTGGAGCCGCCACGAGCAAGACGGATGGTTACCATGTGAACTTCGTTCCTGTAGTCGGTGCTTGCAAAATGAATGCACGCTGGGCCCACGGCCCGAAAGGCCGCATATTCTAAGGATTATCGGGGAATTTGCAAATCTCTTTTTCGGCCACCCATCGGCCGGCGCGGAGAGCGCGGGAAGCACACGGTCCGCCCGCCGGCCGACGGCGCGAAACCGCCGGCGTGGCCAGCGGCCGCGCGTCCGATCAAAGCTTGGGCATGCCCCCCGGGAACATACTGCCCATGCCTCGCATCATCTTGGCCATGCCGCCCTTGGCGGTGACCTTCTTCATCATCTTCTGCATCTGCTTGTGCTGCTTGATCAGCCGGCCGACGTCCTGCACCTGGGTACCGGAGCCAAGGGCGATGCGGCGCTTGCGCGAGCCGCTGATCATTTCCGGATCGCGCCGTTCGCCGGGCGTCATCGAGTTGATGATCGCCTCCATCTGCTTGAACTGTTTCTCCGCAGCACCCTGGGCATTGCCCATCTGCGCCAGGTTGACCCCGCCGAGCATCGGCAGCTTGTCCATGAGCCCGCCGAGGCCGCCCATGTTCTTCATCTGTTGCAACTGGTCGCGGAAGTCTTCCAGGTCGAAGCCCTTGCCCTTCTTGATCTTCTTCGCCAGCTTCTCGGCCTTGTCGCGGTCGAGGTTCTGCTCGGCCTGTTCGATCAGGCTGAGCACGTCGCCCATGCCGAGGATGCGCGAGGCCACGCGGTCGGGATGGAACGGATCGAGCGCTTCGCTCTTTTCGCCCATGCCGAGGAACTTGATCGGCTTGCCGGTGATCGCCCGCACCGAGAGCGCGGCACCACCACGCGCGTCGCCGTCGACCTTGGTCAGGACCACGCCGGTCAGCGGCAAGGCGTCATTGAAGGCCTTGGCGGTGTTGGCGGCGTCCTGGCCGGTCATGGCATCGACCACGAACAGGGTTTCCGCCGGCTTGATCGCCGCGTGCACCTGCTTGATCTCGTCCATCATGTCGGCATCGATGTGCAGGCGGCCTGCGGTATCGACGATCACCACGTCGATGAACTTCAGTCTCGCCTCGCGGATCGCCGCCTCGGCGATGGCCACCGGCTTCTGGCTGACGTCGGAAGGGAAGAAGGTTACGCCAACCTCGCCCGCCAGGGTTTCCAACTGCTTGATCGCGGCGGGTCGGTAGACGTCGGCGGAAACCACCATCACCGACTTCTTCTTGCGTTCCTTAAGGAAGCGCGCCAGCTTGCCCGCGGTGGTGGTCTTGCCCGCGCCCTGCAGGCCGGCCATCAGGATCACCGCCGGCGGCGCGACGCTCAGCGCCAGGTCCTCGTTGGCCGCCCCCATCAGCTCCTCGAGCTCGGCGCGGACGATCTTCACGAACGCCTGTCCCGGGGTCAGGCTCTTCGAGACCTCGGTACCGACGGCGCGCTCCTTGACCTTGTTGACGAAGTCCTTGACCACCGGCAGGGCCACGTCGGCCTCGAGCAGGGCCATGCGCACTTCGCGCAGAGTGTCCTTGATGTTGTCCTCGGTCAGCTTGGCCTTGCCGGTGACATGGCGAAGCGTCTGCGAGAGGCGGTCTGTAAGGTTTTCGAACATGCGCGATCCTTCCACGGGGGTTGCGGCAAGCGGCGGATTATAACCAAGAGCGCGTCGCGGGACACGCGATGAAAGACGGAGTGTGTGTCCGGCGACGACCGGAGGCCAGCCTCAAGTCCTTGATTTGCCGATGCGTTCCGTCTTTGCCGAAGCGACCGCCGGACCATGAGGTCGCGGCGCCCGCGGCAGGCGGTCCGCCAACCCGGCCACAGGTACGAGAGAACTGTTCGCAACGGCTTTCTCGCGACGCTCGATCTATGCCAAACTCCCATCCTTTCGGGCCCGCGATTACAAGGACTTATGCATCCCCTGCTGCCCAGCCTCATCGCTGCTGTTCTCTATCTCGGCACCGCCGCCTACCAGGGTGCCTGTGTGTCCAAGCGCACCGCGCCGGGCAAACCCCTGCTGCTCCTGTTCGGACTCCTGGCACTGGTCGCCCACGCCTTCAGCCTCTACCAGCAATTGCTGACCCCGGCCGGCCTGGTGCTGGACTTCTTCAACGCCGCCAGCCTGATCGCCGCCGCGGTAATTCTCCTGACCCTGCTGGCGACCTTGCGGATACCGGTGGAGAACCTGCTCCTCCTTCTATTCCCGCTGGGTGCCCTCACCACCCTGCTGGCGGTACTCATCCCCCACGGCACCGTCGAGCCGATCAACGAACAGCCAGGCATTCTGGCCCACATCCTGCTCTCGATCCTGGCCTACGGCCTGCTCACCATCGCGGTGTTCCAGGCGCTCTTGCTGCTGCTCCAGGACTACCGCCTCAAGCACAAGCATCCGTCCGGGCTGATCCGCAACTTCCCGCCCCTGCAAACCATGGAAAGCCTGCTGTTCGGCTTCCTCTGGGGCGGCTGGTCGCTGCTTTCGCTGTCGCTGCTGTCCGGATGGCTGTTCGTCGACAACCTGTTCGCCCAGCACCTGGCGCACAAGACCATCCTGTCCTGCTTCGCCTGGGTGGTCTTCGCCGTGCTCCTCTGGGGTCGCCACCAGCTCGGCTGGCGGGGCCACAAGGCGATCCGCTGGACCCTGGCCGGTTTCTGCCTGTTGATGTTGGCGTACTTCGGCAGCAAGCTGGTGCGGGAATTCATCCTGCACATCTGATGGGCCTCCTTCATGGATGAGCTGCACCCCGGGTACCTGGTCGGCCTGCTGGTTCTCCTGGTCGCCTGCTCGGCGTTCTTCTCCTGCGTCGAGACCGCCCTGCTCAACCTCGACCGTTACCGCCTGCGCCTGCAGGCCAAGCAAGGCCTGCGCGGGGCCCGGCGCAGCAGTTGGCTGCTGCTGCACGACGACCGCCTGCGCGGCACCCTGTTGTTCGGCCGCACCCTGGTCAACGTCAGCGCCGCCGCCCTGGCCAGTTGGGCCGCGCTGCGCCACTGGGGCGTCATCGGCCTGGCCGTCGCCATCCCCGGCATGACCCTGCTCCTGCTGCTGTTCGGCGCCCTGCTGCCGCGCCGCTACGGCGCCCTTCGCTCGGAACGCGTCGCCCTGCCGCTCAGCCTGCCGCTCCTGATCCTGCAGCGCCTGTGCTGGCCCCTGCTGTGGCTGCTGACCCTGCTGAGCAACGCGCTGCTGCGCCTGCTCGGCGTCGCCGCGGCGGAACAGGACGACAGCGGACGCAGCCGCGACGAAGAGGCCCTGCATCCGGCCGACAATCCCCAGGCCAGCGAGGTCAACCGGCATGACATGCTGCTCGGCCTGCTGGACCTGGAGAAGGTCACGGTCAACGACCTGATGATCCCGCGCAACGAAATCGAAGGCATCGACCTCGACGACGAACTCGAGGTCATCGTCGAGCAGTTGCGCACCACCAGCCACACCCGCCTGCCGGTCTACCGCGACGACGTCAACCAGATCGAAGGGGTCGTGCACATGCGCCAGATCGCGCGCCTGCTGACCCAGGGCCGCCTGACCAAGGAGAATCTCCGCCAGGCCTGCATGGAGCCGTATTTCGTGCCGGAAAGCACGCCGCTGTCGACCCAGTTGGTGAACTTCCAGAAGGAGAAGCGCCGTATCGGCGTGGTGGTCGACGAATATGGCGAGGTGATCGGCATCGTCACGCTGGAGGACATCCTCGAAGAGATCGTCGGCGACTTCAACGACCTCGACAGCCTCGACAACCCGGATATCCAGGCCCAGGAGGACGGCAGCTTCGTCATCGACGGCAGCGCCAACCTGCGCGAGCTGAACAAGTCGCTTGGCTGGCAATTGCCCTGCGACGGCCCGAAGACCCTCAACGGCCTGGTCACCGAAGCCCTGGAGCAGATCCCCGATTGCGCGGTGTGCCTGCGCATCGGCCCCTACTGCCTGGAAATCCAGCAGTCGGCGGAAAACCGTGTGAAAAGCGTGCGCGCCTGGCATCCCCGCGCGCTGACCCCGCTGGTCGAAAGCGACGCCAGCGTCTGATCCGGGATTGCCGAACCGGCCCCGCGGCGCTCTATAATCGACCCCAGCTTATCCAGCCCTGCCGCCGGTTCCGCCGCTACCCGCAGCCCGAGCCCCGGCCAGTCACCCGCCAGTCCCGCCTGCCCGCCCGGCCCCGATGCCGACGGTACCAGCCGGCGCACGGCGCGCAGCCCCATCCTCCCTGCGCGACCGATCTCGTCCGCCCCACCCGGGCGCCGCGCCGCCGCATCGGCGCACTGGCCATAACCATCCGGCCGCACGGAAGCACTCCGTCGTGCCCCGACTGCCAGGGACCTTCCCACCATGACCGCCGCCACCCTCGCCGCCGACGCCGCTCCGGAACCGGCCAACTCGACCACCCGGGTCGCAGTCGCCAGCTTCATCGGCACCGCCATCGAGTTCTACGATTTCTACGTCTATGCCACTGCCGCCGCCCTGGTGATCGGTCCGGTATTCTTCCCGCAGACATCCGGCACCGCGCAGATGCTCAGCGCCTTCCTCACCTTCGGCATCGCCTTCCTCGCCCGTCCGCTGGGCTCGGCGCTGTTCGGCCACTTCGGCGACCGCATCGGGCGCAAGTCGACCCTGGTCGCCTCGCTGCTGCTGATGGGGGTGTCCACCACCCTGATCGGCGTCCTCCCCGGCTACGACAGCATCGGCTACTGGGCGCCGTTGCTGCTCTGCGTGCTGCGCTTCGGCCAGGGCCTCGGCCTCGGCGGCGAGTGGGGCGGCGCCGCGCTGCTGGCCACGGAGAACGCGCCGGCCGGCAAGCGCGCCTGGTTCGGCATGTTTCCCCAGCTTGGCCCGTCGATCGGCTTCCTCGCCGCCAACGGCCTGTTCCTGGCCCTGGCGATGCTGCTCAGCGAGGAGCAGTTCCGTGAGTGGGGCTGGCGGATCCCGTTCCTGCTCAGCGCGGCGCTGGTTGTGGTCGGCCTCTACGTACGCCTGAAGCTGGCGGAAACCCCGGTGTTCGCCAAGGCCATGGCCAAGCACGAGAGGGTCCGCCTGCCGATCGCCGAGCTGTTCGCCCAGCACTGGCGGCCGACCCTGCTCGGCGCCCTGGCGATGGTGGTGTGTTATGCGCTGTTCTATATCTCCACGGTGTTCTCGCTGAGCTACGGGGTGGCCAGCCTCGGCTTCAGCCGCGAGGAGTTCCTTGGTCTGCTGTGCCTCGCGGTGCTCTTCATGGCCGCCGCCACGCCGCTGTCGGCCTGGCTCAGCGACCGCTTCGGACGCAAGCCGGTACTGCTGCTCGGCAGCCTGGCGGCGATCGCCTCCGGCTTCGCCATGGAGCCGCTGCTCAGCCAGGGCTCGACGTTCAGCGTCGCCCTGTTCCTCTGCATCGAGCTGTTCCTGATGGGGGTCACCTTCGCCCCGATGGGCGCGCTGCTGCCGGAAATATTCCCCACCCACGTGCGCTACACCGGCGCGTCGGCGGCCTACAACCTGGGCGGCATTCTCGGCGCCTCGGTGGCGCCCTATATCGCCCAGAAGCTGGTCGGCATCGGCGGCCTGGGCTGGGTCGGCGGCTACGTCTCCGCAGCGGCGCTGCTCAGCCTGCTGGCGGTGCTGTGCCTGAAGGAAACCCGCGACAACGACCTCGGCGCAGTGTCCTGAGTCTCGCTCAGGCTACCGCGACGCCGCCCTTCTCCCTCGCCGCCAACCAGTCGGCGAGGGCCCCGGCCCAGACCTGGTAGCCCAGCTGCGACGGATGAAAGCCGTCGATGGCCAGGTAGCCCGGAAGCAGGTCCAGCGAGATCGGGCAGTAGCCGGCGCCGGTCGCGCCAGCGAGATCGCACAGCGCCTCGTCGAGCAGCCGCCCGCGCCACCCCAGCAGGGCCCGCAGCAACCCGGGCAAGGCGGAAAAATGCTGCAGCGGCGGCACCGCGGTGCAGGTCACCTGCGCGCCGGCCGCCTGGAAGCCGTCGATCAGGGCCGCGCAGTCGGCGCGCCAGCGTTCGAGGGAGCGCAGGCTGGTGGTGTCATTGACGCCGAAGACCAGGATCACCTGGTCGAAGAAACGTCCCGCCACCTGCGGTAGCAAGCGTTCGCGCGCCTCGCCGCTGGTGATGCCGTTCTCGCCCAGCGCCTGCCAGGCCACCGGGCGCCGCAGACGCTCGCCCAGCGCCGCGGCCAGGCGGCCGGCCAGGGCGTAGTCCAGGCAACTGGCGCCGACCCCGGCCACTGTCGACTCACCGAACAACAGCAAGCGCAGCGGCTCTTCGGCACCGGACCCACCGACCAGCCCTTCGCGAGGTCCCGCCGCGGGCGCCAGGCGCAAGGCTCGGCGGCGGGTGCGGATAGCCAGCGGCACCGCCAGCGGCAGCAACGGCAGAGCCGCCGCCCACCAGGCCAGCGTTGCCAGCCGGCGCATCTCAGAGTTCGACGCGAACCGCCTGGGCGGCCCGGGTCGCCTTGGCGCGGGCGGCGTCGATAGACTCGTCGCGCGCCAGGGCCACGCCCATCCGCCGCTGGCCATCCACTTCCGGCTTGCCGAACAGGCGTAGCGCCGTATCCGCCTCGCTCAGCGCGGCACCGAGGTTGGCGAAAGCGACCTGCCGGGACTTGCCTTCCACCAGGATCACCGCCGAGGCCGACGGGCCGAGCTGGCGGATCACCGGGATCGGCAGGCCGAGGATCGCCCGCGCGTGCAGCGCGAACTCGGAAAGATCCTGGGAAATCAGGGTCACCAGGCCGGTATCGTGCGGGCGCGGCGACACCTCGCTGAACCACACCTGGTCGCCCTTGACGAACAGTTCGACGCCGAACAGCCCGCGTCCGCCGAGGGCCTCGGTCACTGCCCGGGCGACCCGCTCGGACTCGGCCAGGGCCTGCGCGCTCATCGCCTGCGGCTGCCAGGACTCGTGGTAGTCGCCCTTGACCTGGCGGTGACCGATCGGCGCGCAGAAAGTGGTGCCGTCGACGTGGCGCACGGTGAGCAGGGTGATTTCGTAGTCGAAATCGATGAAGCCCTCGACGATCACCCGGCCCTTGCCGGCGCGCCCGCCTTCCTGGGCATAGTCCCAGGCCGCCTGCAGGTCGTCGGGGCCTTTCAGGACGCTCTGGCCCTTGCCCGACGAACTCATGATCGGCTTCACCACGCAGGGGTAGCCGACGCGCTCGACGCCACGGCGGTAGTCCTCGAAGGTATCGGCGAAGTGATAGGGCGAGGTCGGCAAGCCGAGCTCCTCGGCAGCCAGCCGGCGGATACCCTCGCGGTTCATGGTCAGTTGCGCGGCGCGGGCGGTGGGCACCACGGTGTAGCCTTCGGCCTCCAGCTCGACCAGGGTCGCGGTGGCGATGGCCTCGATCTCCGGCACGATGTAGTGCGGCTTCTCCTGCTCGATCACCGCGCGCAGGGCGGCGCCGTCGAGCATGCTGATCACGTGGCTGCGATGTGCCACCTGCATGGCCGGCGCGTTGCCATAGCGATCGACGGCGATCACTTCGCAACCCAGGCGTTGCAGCTCGATGGCGACTTCCTTGCCCAGCTCGCCGGAGCCACAGAGAAGGACGCGGGTCGCGCTCGGCGACAGGGGGGTACCGATACGGGTCATGGAAGAACCTCGGAAATGAAAGAAAACGGAATCAGCTTCAGGCGGAACCGCTGACCAGCCCTTGCGCCTTGGCGCGCTCGAAACAGCGACCGAGCACCTCGCGGCGCTCGTCGTTGCTCATCAGGCCCCAGCGGGTGATCTCGGCCGCCGTGCGCTGGCAGCCGATACAGATGTCCTGCTCGTCCAGCGCGCAGACATGCACGCAGGGCGAAGCCACCGGTCGCTCGTTCACGCCGGGTCCTCGACGAGGTCGCGGGCGTAACGGCGGGCATTGTGCACATAGTGGGCGGCGCTGGCCTCGAGCATTTTCTTCTGCGGCTCGCTCAGCTCGCGCACTACCTTGCCCGGCGAGCCCATCACCAGCGAGCCGTCGGGAATCTCCTTGCCCTCGGGAATCAGCGCGTTGGCGCCGATGATGCAGTACTTGCCGATCTTCGCCCCATTGAGGATCACCGCGTTGATCCCCACCAGGCTGTAGTCGCCCACGCTGCAACCATGCAGCATGGCGTTGTGGCCGACGGTGACGCCCTTGCCGAGGGTCAGCGGATAGCCCATGTCGGTGTGCATCACCGAGCCGTCCTGGACGTTGCTGTGCTCGCCGATATGGATCAGCTCGTTGTCGCCGCGCAGCACCGCGCCAAACCAGACGCTGGCGCCGGCATCCAGGCGAACCTTGCCGATCACCGCTGCGCTGGGCGCGATCCAGCTGTCGGGATGGGTTTCGACGCGGGCATCGCCCAGGCGGTATTTCATCGCGATCTCCTCATGGCCGGGGTCTGCGCCCCGTCGGTCAACTCAGTTTGATGAACGAAGCCGGCGGCGTGTGCAGGTCGATGGGGTCGTCGTACAGCAGGTTGACCAGCTCCACCACCATGATGGCCGTCAGGCCCCAGATCTTGAACTCGCCGAAGCGATAGCTGGGCACGTACCAGCTGCGGCCGAAGTAGTCGATACGGTGGGTGACCTCGCGCGGGTCGTCGCGAAAGAAACTCAGCGGCACGTTGAACACCGCGGCGATCTCGCCGTCGTTGGGCTGGTACTCGACGAAGTCGGGAATGAAGGCGACATAGGGAGTGACCTCGATGCCATGCCGCGAGACCAGGGTGCTCAGCGGCCCGACCACTTCCACCAGGCCCGGCGGCAAGGCGATCTCCTCCTCCGCCTCGCGCAGGGCGGTGCGCACCAGGTCGGCATCTTCCGGGTCGCGCCGCCCGCCGGGGAAGGCGACCTCGCCGCCATGGGTGGACAAACCGGCGGCGCGCAGGGTCAGCACCAGCTCCGGATCGTCGCTGCGGGTGATGGGCACCAGCACGGCCGCTTGGGGGAAGCGCTGGTCGGTATCCAGTTGGCGGGGGCGGTGCGCCTCGATGCGTTGGCGCAGCTCGTCGAGCGTGCAGTTCATACTGCCGGGGTTTCCGAGGTCTTGTCGTTTCCCCGAGATCATGGCACGAAAGCCCCGGCCAGCCCACCCCTCCCGCACGGGGCCTTGTCGCCTCCCGGCCAGCCGAGCAAGATAGGCCTTTCCCCGAAGAAGAACCTGGCATGAAATTCTGCAGCCTGTGCGGCGCCACGGTGGTCCAGCGCATCCCGGACGGCGACAACCGCCTGCGCTACGTCTGCGACGCCTGCCACACCGTGCACTACCAGAACCCGCGTATCGTCGCCGGCAGCCTGCCGGTGTGGGACGGCCAGGTCCTGCTCTGCCGTCGCGCCATTGCGCCGCGCCTGGGCTACTGGACGCTGCCGGCCGGCTTCATGGAGAACGGCGAGACCCTCGCCCAGGCGGCGGCCCGCGAGACAGAGGAAGAAGCCAACGCGCGGATCGGCGACCTGCAGCTCTATACCCTTTTCGACCTGCCGCACATCAGCCAGGTCTACCTGTTCTTCCGCGCCGAGCTGCTCGACCTGGATTTCTCCGCCGGCGATGAAAGCCTGGAGGTGCGGCTTTTCGACGAAGCGGAGATTCCCTGGTCGGAGCTGGCTTTTCCGACCATCGGCCGTACCTTAGAATGCTACTTCAGCGACCGCCGCGAAGGCTGCTTCCCGGTGCGCAACGAAGCCATTGCACCTATGCTGGCTTCCTATAAGAAAGACTGAACGCCAAACACTCGAACACCGCCGCCGTTGCGGCTCAAGGGAACATCGGGGATTTCACTTCCATGCGCTGGTTGCTTGCTTTGCTGTGCTTGACCTTCGCCAGTCTGACCCAGGCCAATGCCGCGCCGAGCCTGGAAGGCAAGGTGGACAAGGTCCTGGTGCTCAAGTCCGAGCGAAAACTGCTGCTCCTCAACAAAGGCAACGTCCTGAAAAGCTACCGTGTCTCGCTGGGCAAGCGCCCGACCGGCCCGAAGCTGGCCGAAGGCGACAACCGCACCCCGGAAGGCTTCTACTGGATCGACTGGCGCAAGACCAGCAACAACTACAACCTCTCCATGCACATTTCCTACCCCAACGCCCGCGACGTGGCCAAGGCCCGGGAAAAGGGCCTGCCGGCCGGTGGCATGATCATGATCCACGGCACCCCGCTGGATGACGAATACCCGGAGTGGTACTTCTCCACCCTGGACTGGACCAATGGCTGTATCGCCATGAACAACACCGACATGCGCGAAGTCTGGAGCGTGGTGAAAGACGGCACGCTGATCGAGATCCGCCCCTGACAGAACCAGGCTGATACCACTCGTCAGCCGTCAGCCACGCCAGGAACGCCGCCGCGAGATTTTCCGGCGGCGTTTTCTTTTATCCGTCAAACCCTTGCATCCCTTACTCAGGCCGAGTCAATCGACGGGACGGCTGGCTGACGCGTGCGCGACGCACAACTGGCATTGACGTGGTATTCAAGTGGTATTAGTTTTCCCAGCATTACCGGGCGACAACAACACAATCCGCATCGGAACCTCTCATGAAGACAGCCCACGACCTGCTCCTGGCCCTGCGTCCCGACGAGGCGCAACCCACCCCCCTCTATCTGCAGCTGGCGCGCAATCTCGAGAGCGCGATCCATGCCGGCCAGTGGAAAGCGGAGGAAGCGCTGCCCTCCGAACGCAACCTCAGCGAAACCCTGAACATTTCCCGCGTCACCGCGCGCAAGGCCCTCGAAGTACTCTTCGAGCAGGGCCTGATCCGCCGCAACCAGGGCTCCGGCACCTTCATTACGCCGCGTCTCGAACAACCGTTGTCGCGTCTCTCCAGCTTCAGCGAGATGCTCCGCCTGAAAGGCTTCACCCCCGGCTCCACCTGGCTGGAGCGCGGCATCGCCCTGCCCACCCACGACGAACTGATCCGCCTCGGCCTCTCGCCGACCGAGAAGGTCACGCGCATGAAGCGCCTGCGCAAGGCCGACGGCACAGTGATGGCGATCGAGAACAGCACCCTGCCGGCGCGCCTGCTGCCGGACCCGACAGCGGTCGGCGATTCCCTCTACGAATACCTGGACGGCATCGGTCGCCCAGTGGTCCGCGCCCTCCAGCACGTGCGCGCGATCAACGCGTCCGCGTCCGATGCCGCGCTGGTCGGCATCGCGCCGGGCACCGCGATGCTGCTGATGACCCGGATCGGCTACCTCGAGGACAACACCCCGATCGAGCTGACCGACACCTACTGCCGCAACGACTACTACGACTTCGTCGCCGAACTGCGACGCTGACCGACACGGAGCCGCCATGCTCGAAGGCAACATTCTCACCCCGCAAGGCTGGGTCCTCGGCCGCCTACACATCCAGGACGGGCGTATCCAGCGGATCGAAGGCGAGCCCTGCGACCCGGCCGGCAACGCCGATCCGTACCTGCTGCCAGGCTTCATCGACCTGCATGTGCACGGCGGCGGCGGCCGCGACATCATGGAAGGCGGCGACGCCTTCGCCACCATCGCCCGCACCCACCGGCGCTTCGGCACGACCTCGCTGCTGGCCACCACCATGACCGCACCGCGCGAGGAGATCGCCGACATCCTCAGCCAGCTCGGCGCTTACTGCCGCCGCTCGCTGGAGGGCGGTTCACGGATACTCGGCGTGCACCTGGAAGGCCCCTACATCAACTCCGGCAAGCTCGGCGCGCAGCCCAACTTCGCCCATGCCGCGGTGCTCGAGGAAGTCGAGGACTACCTGCGCCGCGCGCCGATCCGGGTGATCACCATCGCCCCCGAGATCGCCGGACACCGGCCGCTGATCCGCGCCCTCGCCGAGCGCGGCGTACGCCTGCAGATCGGCCATACCCTGGGCAGCTACGAGGACGGCGTGGCCGCACTGGAAGCCGGCGCCAGCAGCTTCACCCACCTCTACAACGCGATGACCGGCCTGCACCACCGCGAACCGGGTATCGTCGGCGCGGCCCTGGCCCACGCACGCTACGCCGAGCTGATCCCCGACCTGCTGCATGTCCATCCCGGCGCCATCAGGGTGGCCCTGCGTTCGATCCCGTGCCTGTACTGCGTGACCGACTCCACCGCCGCCGCCGGCATGCCCGACGGCCAGTACAAGCTCGGCAGCCACACGGTGACCAAGTGCCTGGGCGGCGTGCGCCTGCCCGACGGCACCCTGGCCGGCAGCACCCTGACCATGGACCAGGCGCTGCGCAACCTGGTGAAGATCGGCCTGCCCCTGGCCGAAGCCTCGCAACGCCTTTCGCAATTCCCCGCCGATTACCTCGGCCTCGCCGAGCGCGGCCGCCTGGCGCCCGCAGCCTGGGCCGATGTGGTGCGCCTGGATCGCTCCCTGGAACTCGACGCCGTGATGGTGGAAGGAGAACTCGAATGACTTCGCTGATGCTCGAGGAAGCGCTCTCCGCCGCCGCGGTGGCGAGCCGTCAACTGGCCGTGCTCGACGCTTGCCTGCCGGCGCTTGGCCAGCGCCTGCGGGAGGTCGATCCAAACCTGGCGCTGACCGTCGCGCGCGGCAGCTCCGACCATGCCGCCAGCTACTTCGCCTACCTGGCCATGCAGCACGCCGGCTTGCCGGTGGCCTCGCTGCCCATGTCGGTAGTGACCCTGAACCGCTCGCCGCTGCGTGTCGCCGGGCAGGCCGTCTTCGCTTTCTCGCAGTCAGGACAGAGCCCCGATCTCGTGGACAGCCTGCGCATCCTGCGCGAACGCGGCGCCCTGGGCATCGCCCTGGTGAATGCCGAAGATTCGCCGCTGGAAGCCGCCAGCGAATTCGTCGTGCCGCTCTGCGCCGGCACCGAGCGCAGCGTCGCAGCGACCAAGAGCTTCATCGCCACGCTCAGCGCCAGCGCCCGCCTGCTCGCCCACTGGCAGCGCGACAATGCCCTGCTGGCCGCCGGCCAGGGCCTGGCGGCCGGGCTGGAGCAGGCCGCCAGGCTCGACTGGTCGCCGGCCATCGAGGCCCTGCGCGACTGCCAGCGGCTGATGGTGATCGGTCGCGGCGCCGGCTACGCCATCGCCCAGGAGGCCGCGCTGAAATTCAAGGAAACCTCGGCGATCCAGGCCGAGGCCTTCAGCAGCGCCGAGGTCCGCCATGGACCGATGGCGCTGGTCGAGGAGCGCTATCCGCTGCTGGTGTTCGCTCCCCGCGGCCCGGAGCAGGAAGGCCTGCTGGCGCTCGCCGAGGATATGCGCCAACGCGGTGCGCAGGTATTGCTCGCTGCCCCGGACGACATCGCCGAACGCGACCTGCCGCTGCAGCGCGCCGCGCATCCGGCGCTCGATCCGATCCTGGCGATCCAGAGCTTCTACGTCATGGCCGCCGGCCTGGCCGAAGCCCGCGGCATGGACCCGGACCAGCCACGGCACCTGAGCAAAGTCACCCGAACCCACTGAGCCTGAGCGCGCGCCCATGAACAACAAGAATCTCGCCCTCAAAGCGCCCCTGAGCGGCCCCGTGATGCCGCTCAACCGAGTACCCGACCCGGTGTTTTCCAGCGGCACCCTGGGCGAAGGCATCGCCATCGACCCACTCAACGACTGCCTGCACGCGCCCTGCGCCGGGCTGGTCAGCCACCTGGCGCGAACCCGCCACGCGCTCAGCCTGCGCGCCGACAACGGTGCCGAGCTGCTGCTGCACGTCGGCCTCGATACAGTACAGCTGCAAGGCGAAGGCTTCGAGGCGCTGGTCGAGGAAGGTGCGCGGGTGATCGAGGGCCAGCCGCTGCTGCGCTTCGACCTGGACCGCGTCGCCCGCGGCAGCCGCAGTCTGATCACGGTGATGATCCTGACCAACGGCGACGGCTTCCAGGTACGCCCGCTGACCACCAACCCGGTGGAGGTCGGCGCGCCGCTCCTGCAACTGAGTCCGGAGAAGGCCGAGCAACGTCCGGCCAATCCCGCGCCTGGCGAAGGCTCCGCGCAGCGCCAGGTCCGCGGGCGGGCGCGGGTCGCCCATCATGGCGGTCTGCACGCACGCCCGGCAGCGCTGCTACGGAAGACCGCGCAGGGCTTTTCCAGCCAGGCCGAACTGCACTTCGCCGGGCAGGTGGCCAGCGTCGACAGCCTGGTCGGCATCATGGGCCTGGGGGTCGCCGAACAGGACGAGGTAGAGGTGATCTGTCGCGGCGAAGACAGCGAGGCGGCCCTCGACGCCCTGCTCGCGGCCCTCGCCAGCGCCACCGCGGGGGCTCCGAAGGAGGCCCCGCGCGCCATCGCCTCGGGCGAGCCGGCGCGACCTGCGGCTGTCGCCGGTACCCTGGCCGGCGTCTGCGCTTCGCCCGGCCTGGCCAGCGGTCCCCTGGCGCGGCTCGGCGCCATCAGCCTGCCGGCGGATGACGGCCGGCATCGTCCCGAGGAACAGCACCTCGCCCTGGACCAGGCCCTGCAACGGGTGCGCGACGACGTACAGGGGAGCCTGCAGCAGGCCAGGCTCGGCGGCGACGAGAACGAAGCGGCGATCTTTTCCGCGCATCTCGCGCTGCTGGAAGACCCGGGTCTGCTGGACGCCGCCGACATGCTGATCGACCAGGGCGTCGGCGCCGCCCACGCCTGGCACCGGGCGATTCAGGCCCAGTGCGAGATTCTCCAGGCGCTGGGCAACCTGCTGCTGGCCGAGCGCGCCAACGACCTGCGCGACCTGGAAAAACGCGTGCTGCGGGTGCTGCTCGGCGACACCGCACCGTTGCGGGTGCCTGCTGGGGCCATCGTCGCCGCCCGGGAGATCACCCCCTCCGACCTCGCGCCGCTGGTGGATGCCGGCGCGGCTGGCCTGTGCATGGCCGAAGGCGGCGCCACCTCCCACGTGGCCATCCTCGCCCGTAGCAAGGGCCTGCCGTGCCTGGTGGCGCTCGGCGCCGGGCTGCTGGAGCTGGAGGAAGGCCGGCAGGTAGTACTGGACGCCGGCCAGGGCCGGCTGGAACTCAGCCCCGACGCTCGACGCCTGGAGCAGGTCGCCTTGCAAGTGGCGCAGCGCGAGGAACAACACCGCCGCCAGCAGGCCGATGCGCAGCGCGAGGCGCTCACCCGCGACGGCCGGCGCATCGAGATCGGCGCCAACGTCGCCTCGCCGCGCGAGGCCGCCGAAGCCTTCGCCAACGGCGCCGACGGGGTCGGCCTGCTACGCACCGAGTTTCTCTTCCTCGAGCGCCGCGCCGCGCCCGACGAAGAGGAGCAGCGCAACGCCTACCAGGAGGTCCTGGACGCCATGGGCCAGCGCAAGGTGATCATCCGCACCATCGATGTCGGCGGCGACAAGCACCTCGACTACCTGCCGCTGCCGGTGGAAGAAAACCCAGCACTGGGCCTGCGCGGCATCCGCCTCGGCCAGGCGCGCCCGGAGCTGCTCGACCAGCAGTTGCGCGCGCTGCTGAGGGTCGAACCACTGGAACGCTGCCGGATACTGCTGCCGATGGTCAGCGAGGTCGACGAACTGCGCGCCATCCGTCGCCGCCTCGGCGAGCTGGCCACGCAGTTGGGGATCGAGCGCCTGCCCGAACTCGGGGTGATGATCGAGGTGCCCTCCGCCGCCCTGCTCGCCGATCAACTGGCCGAACACGCCGACTTCCTCTCCATCGGCACCAACGACCTGTCGCAGTACGCCCTGGCCATGGACCGTTGCCACGCCGGCCTGGCCGACCGCATCGACGCCCTGCACCCGGCGCTGCTGCGGCTGATCGCCCAGACCTGCGCCGGAGCAGCCCGCCACGGCCGCTGGGTCGGCGTCTGCGGTGCGCTGGCCTCGGACCCGCTGGCGACACCGGTACTGGTCGGCCTCGGGGTCGAGGAATTGTCCGTCGGGCCGAACCTGGTCGGCGAGATCAAGACCCGGGTGCGCCAGCTCGACGCCGCCGAATGCCGCCGCCACGCCCAGGCGCTACTGGACCTGGGCAGCGCCCGGGCGGTGCGCGACGCCTGCCTGCAACACTGGCCGCTGGCCTGACAAGAACAATCGGAGACCACCGCCATGCCCCCGTTCCTGATCGAAAGCCTGCAACGCCTGGGCCGCGCCCTGATGCTGCCGATCGCGATCCTGCCGATCGCCGGCCTGCTGCTGCGCCTGGGCGACGTCGACCTGCTCGACATTCCGCTGGTCCACGACGCCGGCAAGGCGATCTTCGCCAACCTGGCGCTGATCTTCGCCATCGGCATCGCCGTCGGTTTCGCTCGCGACAACAATGGCACCGCCGGCCTCGCCGGCGCCATCGGCTACCTGGTGATGATCTCGGTGCTCAAGGTGATCGATCCGGGCATCGACATGGGCGTGCTCTCCGGCATCATCAGCGGCCTGGTGGCTGGCGCCCTGTATAACCGCTTCAAGGACGTGAAGCTGCCGGAATACCTGGCGTTCTTCGGCGGCCGCCGCTTCGTGCCGATCGCCACCGGGATCAGCGCGGTCTGCCTGGGCCTGCTGTTCGGGGTGATCTGGCCACCGCTGCAACAGGGCATCAACGGCCTCGGCCAACTCATGCTGGAAAGCGGCAGCTTCGGCGCCTTCGCCTTCGGCGTGCTGAACCGCCTGCTGATCGTCACCGGGTTGCACCACATCCTCAACAACCTGGTGTGGTTCGTCTTCGGTAGCTTCACCGACCCGGAAACCGGGCGCGTCGTCACCGGCGACCTGGCGCGCTATTTCGCCGGCGACCCGAAGGGCGGCCAGTTCATGGCCGGGATGTTCCCGGTGATGATGTTCGGCCTGCCCGCCGCCTGCCTGGCGATGTACCGCAACGCCCGTGCGGAGCGGCGCAAGCTGATCGGCGGGCTGCTCCTGTCGATGGCCTTGACCGCCTTCCTCACCGGCGTCACCGAGCCGGTGGAGTTCGCCTTCATGTTCCTCGCGCCGCTGCTCTACCTGCTGCATGCGCTGCTCACCGGCCTGTCCATGGCCCTCACCGACCTGCTCGACATCCGCCTCGGCTTCACCTTCTCCGGTGGCGCCATCGACCTCGCCCTGGGCTGGGGCCGCTCCACCCACGGCTGGATGCTCTGGCCGCTGGGCCTGCTCTATGCCGGCATCTATTACCTGGTGTTCGACTTCTGCATCCGCCGCTTCAACCTGAAGACCCCGGGCCGCGAAGACGACGCGAGCAGCGAATCGGGCGACAACGCCGAAGCCGAGCGCGCCCCGGCATTCATCCGCGCCTTGGGTGGCGCAGCCAACCTCGAAGTGGTGGACGCCTGCACCACGCGCCTGCGTCTGCGCCTGGTCGACCGCGACAAGGCCTCGGACGCCCAACTCAAGGCCCTCGGTGCGATGGCCGTGGTACGTCCGGGCAAGGCCGGCAGCCTGCAGGTGGTGGTCGGCCCACAGGCCGACAGCATCGCCGACGAGATCCGCCGCGCCCTGCCCTTCGATACGCAACCGGGCGAAGCCGTACCGCCGCTGGGCAGTCCGCACACAGCCGAAGAGGTGGTGGCGATGCAGGCCACCGTCGACGCCGCCGAAGCCCAGGCCTGGCTCGGCGCCCTCGGCGGCGCCGGCAACCTGCGCGAGGTACGGGACGTCGCACTGACCCGCCTGCGGGTCAGCGTGGCGGACGAACGCAAGCTGGCCACCGAGCAACTGCGTCGTCTCGGCGGACAGGGCGTCAGTTCCCTCGCCGGCGGCATCTGCCATATCCTGGTGGGCCCCCGCGCCGCGGCCCTGAGCCAGGCCCTGCAACCGCTGCTGCGGCGCTGACGGCAGGAGGGCTGGACCTCGGCCAATCGGCGGATAACCGCCAAGCGGTTATTCGCCCCACGCCACAGCTCCCCCGTTCGGGTTCGATAATCGCGAAGCGGTTGTTCGCGCCACGCCACAGCCCCGGGTCGGGCTCTCCCCGTGAGGCGGATAACGAAAAGGGCGGCCACTGGCCGCCCTTCTTGCTTGTCCGAGGAAAACTCAGAAGACCATGTCGGTCAGGCGCCAGACTTCGTAGGCCGGGGTCTCATAGGGATGCGCCGCCTTCAGCGCCTTGACGCTGGCGTGGATGAGCTCGTCGGCCACCACCAGCTCCACTTTCCACTCCGCCACGTGCTCGACCTGGCCGACCTGGCCCAGGTAGGGTTGGCTACCGTCCAGGGGCCGGAACTGGCCCTGGCCAAGGGACTGCCAGCAGCAACTGTCGTACGCCCCGATGCGCCCGCCACCCGCGGCGAACACCGCTTGCTTGACGACATCCAGATGGCTCTCAGGCACATAGAAACACAGCTTGTACATCGTTTTCTCCGCACGAATCGAATGCTGCACGAGGCGGTCGGTGGTTGTGCGACTGCCGACGCCAAATAATGGCACTTTGCCTTGACATGATGAATATTTGACGCTGCCTTTACGACAGATAAGCGCAACATTTGTTCGCTCGTCACAACACCTTCGTGCGGGCGTTCACAGATTTACGTTCAGCCGCGGAAACGCCGCCACCTGGCCTTCAGCCCGGAGGCGGAAGGCGCATGGCTGCCGTCGCAATACGGCAGGTCGGCGGAGCGCCCGCAGCGGCACAACAGCAACAGGCGCTCGCGGGTCGCGTGGAGCGTCAGGCCGTTGCGGCAGTCGGCGGGACAATCGGGAAGCGAAGCCGAAGCCCCGCAGGTACAGAGCCGCAAGGTGTCGCCGGGAGAGACCCGGCGAACCTCGGGAAGAAGGTCGGGCGACGAGTTGGAGTCCGCATCGCCCGCCATGCCGGATCAGTCCACCCAGACCCGGGCGTTGCGGAACATGCGCAGCCAGCCGCCGTCTTCCTGCCAGTCGTCCGGACGCCAGGAATTCTGCACGGCGCGGAACACCCGCTCGGGGTGCGGCATCATGATGGTGACCCGGCCGTCGCGGCTGCTCAGCCCGGTGATGCCGCGCGGCGACCCGTTGGGGTTGGCCGGGTAGGCTTCGGTGACCTTGCCGTGGTTGTCGACGAAACGCAGCGACACGCAGCCGGAAAGGTCGGCCTCGAGCAACGCTTCCTCCGACTCGAACTCCGCATGGCCTTCGCCATGGGCGATGGCGATCGGCAGGCGCGAACCGGCCATGCCCTGCAGGAAGATCGACGACGACTCCTGCACCTGGACCATCGCCACCCGCGCCTCGAACTGCTCGGAACGGTTGCGCACGAAGTGCGGCCAGAACTCGGTGCCGGGAATCAGCTCGTGCAGGTTGGACATCATCTGGCAGCCGTTGCAGACGCCGAGGGCGAAGCTGTCCTTGCGCGCGAAGAACGCCTGGAAGCCGTCGCGGGCGCGGGCGTTGAAGAGGATCGACTTGGCCCAGCCCTCGCCGGCGCCGAGCACGTCGCCGTAGGAGAAGCCACCGCAGGCCACCAGGCCCTTGAAGGCGTCCAGGTCGACCCGCCCGGCGAGGATGTCGCTCATGTGCACGTCGATCGCGGCGAAGCCGGCGCGGTCGAACGCCGCGGCCATCTCCACCTGGCCGTTGACGCCCTGCTCGCGGAGGATCGCCACTTTCGGCCGCACGCCCTTCTTGATGTAGGGCGCGGCGATGTCGTCGTTGACGTCGTAGCTGAGCTTGATCGACAGCCCGGGGTTGTCTTCGTCCAGCAGCGCGTCGAACTCCTGCTCGGCGCAGTCGGCGTTGTCGCGCAGACGCTGGATCTGGTAGCTGGTCTCGCTCCAGATGCGTTGCAGGATGCGGCGCTGGGCGCTGTAGACGGTCTCGCCGTTGTAGTTCAGGTTGATCTCGTAGCCGTTGACCGGCTGGCCGATCACCGCCACGCAGTCGTCGAGACCGGCGGCGCTGAACTGCGCGAGGACTTCCGGAGTGGCACCCTCGCGAACCTGGATCACCGCGCCCAGTTCCTCGCTGAACAACACGGCCGCCAGCTCTTCGCGGCTATCGGCCAGGGCATCGAGGTTCAGCTCGACGCCGCAGTGACCGGCGAAGGCCATCTCCAGCACGCTGGTGATCAGGCCGCCGTCGGAACGGTCGTGGTAGGCGAGGATATGGCCGTCGGCATTGAGCCCCTGGATCACCGCGAAGAAGGCTTTCAGGTCCTCGGCGTCGTCGACGTCCGGCACGGCGCGGCCGAGCTTGCCGTGGACCTGGGCCAGGATCGAGCCGCCGAGACGGTTCTTGCCGCGGCCGAGATCGATCAGGATCAGGTCGGTCTCGCCCTTGTCCAGGCGCAGTTGCGGGGTCAGGCTCTGGCGCACGTCGGCGACCGGGGCGAAGCCGGTGACGATCAGCGAGACCGGAGAAGTGACGCTCTTGTCCTCGCCATTGTCCTGCCAGCGGGTCTTCATGGACATCGAGTCCTTGCCCACCGGGATGGTGATGCCCAGTTCCGGGCACAGTTCCATGCCCACGGCCTTGACCGTGTCATACAGGCGCGCGTCCTCGCCGGGGTGGCCGGCGGCGGCCATCCAGTTGGCGGAAAGCTTGATGTCGGACAGCTTGCCGATACGCGCGGCAGCCAGGTTGGTGACCGTCTCGCCGATGGCCATGCGTCCGGAAGCCGGGGCGTCCAGCAGCGCCAGCGGGGTACGTTCGCCCATCGCCATGGCCTCGCCGGTGTAGACGTCGAAGCTGGTGGCGGTGACGGCGCAGTCGGCCACCGGCACCTGCCAGGGCCCGACCATCTGGTCGCGGGCCACCAGCCCGGTGATGGTGCGGTCGCCGATGGTGATCAGGAAGCTCTTGCTGGCCACGGCGGGATGGCGCAGGACGCGCTCGACGCTTTCCTGCAGCTCCAGCCCGGCGGCGTCGAAATCGTCGCCCAGCTCGGCCTCGCGGGTGACCGCGCGGTGCATGCGCGGCGCCTTGCCGAGCAGGACTTCCAGCGGCATGTCCACCGGCTTGTTGTCGAAATGGCTGTCGGCGACGGTCAGCTGGCGCTGCTCGATGGCCTCGCCGACCACCGCGAACGGGCAGCGCTCGCGCTCGCAGATGGCCTTGAAGGTCTCGAAGTCGGCGGCGTCCACCGACAGCACGTAGCGCTCCTGCGACTCGTTGCACCAGATTTCCAGCGGGCTCATGCCCGGCTCGTCGTTGGGCACCGCGCGCAGCTCGAAGCGACCGCCGCGGCCGCCGTCGTTGATCAGTTCCGGCAGGGCGTTGGACAGGCCGCCGGCACCGACGTCATGGATGAAGCTGATCGGGTTGCGCTCGCCGAGCTGCCAGCAGCGGTCGATCACTTCCTGGCAACGTCGCTCCATTTCCGGGTTGTCGCGCTGCACCGAGGCGAAGTCGAGGTCGGCGGAGCTGGCGCCGGTGGCCATCGAAGAGGCGGCGCCGCCGCCCAGGCCGATCAGCATGGCCGGGCCGCCAAGGACGATGAGCTTGGCGCCGACGCTGATCTCGCCCTTCTGCACGTGTTCGTCGCGAATGTTGCCCATGCCGCCGGCGAGCATGATCGGCTTGTGGTAGCCGCGCACTTCCTCGCCGTGAGGGGTAGCGATCTTCTGCTCGAAGGTACGGAAGTAGCCGGTCAGCGCCGGACGGCCGAACTCGTTGTTGAACGCGGCGCCGCCCAGCGGGCCCTCGATCATGATGTCCAGCGCGGTGACGATGCGCTCGGGCTTGCCGTAGGGCACTTCCCAGGGCTGTTCGAAACCGGGGATCTGCAGGTTGGACACGGTGAAGCCGGTCAGGCCGGCCTTCGGCTTGGCGCCGCGGCCGGTGGCGCCCTCGTCGCGGATCTCGCCGCCGGAACCGGTGGAGGCACCGGGGAACGGCGCGATGGCGGTCGGGTGGTTGTGGGTCTCCACCTTCATCAGGATCTGCACCGGCTCGCGGCTGGCGGCGTATTCGCGGGTCTGCGGATCGGGGAAGAAACGCCCGGCGACATGGCCGACGATGACCGCGGCGTTGTCCTTGTATGCGGACAGCACGCCTTCGCGGTTCATCTCGTAGGTGTTCTTGATCATGCCGAACAGGCTCTTGTCCTGGGCCTGCCCGTCGATGTCCCAACTGGCATTGAAGATCTTGTGCCGGCAATGCTCGGAGTTGGCCTGGGCGAACATCATCAGCTCGACGTCGTGCGGGTTGCGCCCCAGTTCGCCGAAGCTCTTCAGCAGGTAGTCGATCTCGTCCTCGGCCAGGGCCAGGCCCAACTCGACGTTGGCCTTCTCCAGCGCGGCGCGACCGCCGCCAAGCACGTCGACGGCGGTGAGCGGGCGGGGCTGCGCATGGCTGAACAGCTCGGCGGCGCCTTCCAGGCGGTCCAGCACCAGTTGGGTCATGCGGTCATGCAGGCGGGCGGCGACCTGCTGGGCGTCGCTCTCGGACAGTTCGCCCTGCACATAGTAGGCAATGCCGCGCTCCAGCCGGTCGATCTTCGCCAGGCCGCAGTTGCGGGCGATGTCGGAGGCCTTGCTCGACCACGGCGAGATGGTGCCGAAGCGCGGCACCACCAGGAACAGCCGTCCGCTGGGCTCCTGCACCGGCACGCTCGGGCCGTATTTCAGCAGCCGCGCCAGCACCTGCTCCTCGTCGGCGGTGAGCGCGCCGGTGACGTCGGCGAAATGCGCGAACTCAGCGTACAGCCCGGTAACGGCAGGTACGTGCTGGGTCAGTTGCTCGAGCAGTTTGCCGTGGCGGAAAGCGGAAAGGGCGGGAGCGCCGCGCAGGATCAGCATTGTCGGAACAGCCTCTGGAGACGGGAAGGTGTGGGGGCCGGCCGGGCCGGCCCGCAGAGGCCGTGCATTCTACCGTAAAGCACCGTCCGGCGGCACCCGCGCCGATGGCTATCGCATAGCCCTCCATCGGATCCGCGGCGGCCCGCTTCGAAGCACTTCGAGAACGGCGCCGCAGCGCTCTGCGACGGGGCAAGCGAAACGGCGGACGAACGGTATCCCGGCGATAGCAGAGAAGGTCCCGGCTGTCGAGATATGGCGCCGTCTCGCCTTTGCGTATACTGCGCCGATGTTTGCCCTGACCGCGTACCGCTTACGTTGCGCCGCCTGGCTGTTGGCGACCGGCATCTTTCTGCTGCTTGCGGGCTGTAGCGAGGCGAAAGCCCCTACCGCCCTGGAGCGCGTGCAGAAGGAGGGCGTACTGCGCGTGATCACCCGCAACAGCCCGGCCACCTACTTCCAGGACCGCAACGGCGAAACCGGCTTCGAATACGAACTGGCCAAGCGCTTCGCCGAGCGCCTCGGCGTCGAGCTGAAGATCGAGACCGCCGACAACCTCGACGACCTCTATGCCCAGCTTTCCCGCGAGGGCGGCCCGGCGCTCGCCGCGGCCGGCCTGACCCCGGGACGCGAAGACGACGCCAGCGTGCGCTACTCGCACACCTACCTCGACGTCACCCCGCAGATCATCTACCGCAACGGCCAGCAGCGCCCGACCCGCCCGGAAGACCTGGTCGGCAAGCGCATCATGGTGCTCAAGGGCAGCAGCCACGCGGAGCAGCTCGCCGAGCTGAAGAAGCAGTATCCCGAACTGAAGTACGAAGAATCCGATGCTGTCGAAGTGGTCGACCTGTTGCGCATGGTCGACGTCGGCGACATCGACCTGACCCTGGTCGACTCCAACGAACTGGCGATGAACCAGGTGTACTTCCCCAACGTCCGCGTCGCCTTCGACTTCGGCGAAGCCCGCGGGCTGGCCTGGGCCTTGCCGGGGGGCGACGACGACAGCCTGATGAACGAGGTCAACGCGTTCCTCGACCAGGCCAAGAAGGAAGGCCTGCTGCAACGCCTGAAGGACCGTTACTACGGGCATGTCGACGTACTCGGCTACGTCGGCGCCTACACCTTCGCCCAGCACCTGCAGCAACGCCTGCCGCGCTACGAAAGCCACTTCAAGCAGAGCGGCAAGCAGCTGGATACCGACTGGCGCCTGCTCGCCGCCATCGGCTACCAGGAATCGCTGTGGCAGCCCGGCGCCACCTCCAAGACCGGCGTGCGCGGCCTGATGATGCTGACCAACCGGACCGCCCAGGCGATGGGCGTGTCCAACCGGCTCGACCCGAAGCAGAGCATCCAGGGCGGCAGCAAGTATTTCGTGCAGATCCGCAGCGAACTGCCCGAGAGCATCAAGGAACCGGACCGCAGCTGGTTCGCCCTGGCCGCCTACAACATCGGCGGCGCGCACCTGGAAGACGCGCGCAAGATGGCCGAGAAGGAAGGCCTCAACCCGAACAAGTGGCTGGACGTGAAGAAGATGCTGCCGCGCCTGGCGCAGAAGCAGTGGTACGCCAAGACCCGCTACGGCTATGCGCGCGGCGGCGAGACCGTGCACTTCGTACAGAACGTGCGGCGCTACTACGACATCCTCACCTGGGTGACCCAGCCGCAGATGGAAGGCAGCCAGATCGCCGAGAGCGGGTTGCACCTGCCCGGCGTGAACAAGACGCGCCCGGAAGAAGACAGCGGCGACGAGAAACTCTAGCCGCCCCCTCCCCTCAGGATTCTCCGTCGCTTGCCAGCCAGGCGGCGTGCTCGCGCACATCGGTCGGCCAGCCGGCGATCCGCTCGGCGAAGCCCTCGCGATCCCCGGCGAACAGCGCACGCGTCGCCTCCTCGAAGCCCGGCAGGTCGCCGGCCATCGCATTCATGAAATGGTAGGCGCGCTCCTGCGCCTGCCGCGCACGCCCGGACTGGCTGCGGCGCGCCTCCTCGACCAGCTTGCGCAGCGCCACCGAGGCGCCCCCGGGCTGCGCGGCGAGCCATTCCCAGTGGCGCGGCAACAAGGTCACCTCGCGCGCCACCACGCCCAGCTTCGGCCGCCCGCGCCCGCGCGGCGCGGCCTCCTCCGCCGGTTGCCGCTCGCCTGCGACGACCAGGCGCGCCAGCTGGTCCTCGCTGGAACCACGGATATCGAGATCGACGGAGCGCCCAGTGGCATTGTCGAATACCAGCAGCGGTCCGGCTGCACCGCCGGCGACCGCTTGCTTCAAGGCCAGCGCGACCTCCGGCAGCGCCGCCGTCAGCAGCCGGCGCGTGCCGTCGAAGCAGGTGAAGGATTGGATGTATGGATCATTGGCCATGACAGGCTCCCATGGATGGAACGCCCGAATAATACCCGGATATAAATAGAGCGACAATATTATCCGGATAAAATAAATCCCATGAAAAAGGCCGCCCTATGGCGGCCTCTTCCGGCAGCGATGACCTACCAGCCGGCCGGCAGCAGGTTCATGGCGCTGCAAATGGCGTAGGCGGCGCTGGCCAGGTAGATCGTCACGATCACCGCCTGGATCGCCGGATGGGCGATCCAGCCGCATTTCCAGGCCGGCTCGAAGTCGCCGTTCCTACGCGCCGAGCGCAGCATCAGGATCGGCATGATCGAGAGAATCACCCCGCTGAAGGCCCCGGCGAAGTACAACGCGTTGACGAAGCCGACCAGCCCGCTGTAGGCCAGGACGAACGGCGGCAGCGCGACGATCGCCAGCACCAGCAGGCGGGTCTTCGGCCGGTTCTCCGGACCGAGCTTGTGGAACTTGTCGAAGATGTTGGTCAGGAAGCTACCGCCCAGGCCCCAGTAGGACGTCAGCATGGCGCACAGGGCGAAGGTGTTGGCGGTGAAGAAGGCCCATTCGCCGAGCGCCTTGCCCCAGGCCAGGGTGGCGACTTCGGACTGGTTCTCCAGGCCGGTCAGGGCGATCACCGAGAGCGGCACGATGCTGAGCAGGACGAAGGTGGTCAGCATCCCGGTGATCACCGCCTTCGGCAGGCGCTCCGGGGCGTGGCTGAAACCACGGGCCATCTCCGGGACGATGTACTGGGCGGAGAAGCAGAACACCGCGATGTTGAATACCGGCACCATGTAGATCCAGTCGCCGTCGAGCAGACGGGCGAACTCGGTATTGTCGTTGAGCAGGGTGGCCGCCACCAGGATCAGGATCATGCTGACCATGCCGATGCTGATGAACTTCTCGCCCTTGCCGATGGCGCTCAGCCCCAAGTACAGCACGCCGGCGGCCGGAATGAAGAACAGCACGCTGCCCAGGGCCGGGCTGATGCCGAAGAAGGCGCTGAGGATCTTGCCGCTGCCGCTCATGTAGGCGATCAGCGCGCCGATGCTGTTGACCGCCACGGACAGGAAGATCGCCCAGGCGCCGAAGGAGCCGACATAGCGCTGGGCAAGGCCGCTCAACTGGTTGTGGGTGCGCGTGCGCAGGGCGGTTTCCGAGACGTAGAGCATGGAAATGGTGGTGAACAGGCCGGCCACCGCCAGCCAGAGCAGCAATGGCATGAAGCCGGCCTTGCGGCTGGCGTAGGCCATGGACAGCACGCCTGCGCCGATGTTGGTTCCGACGATCATCGCCACCGCCTCGAGGAACGTCAGGCGCTTGACCTCCAGTCCCGAGGAATCGACGGCTTCCGCCCCGGCGTGATCCTGATACTGCTGGACCCGGGTATCACTCATGACAACAACTCCCTGCATTTCGAATTGGCATTGTGCGGGAGGCGGCCAGGACCGCCGTACCGATGGCCTTCTTCGAGGACAATGCAGGGCCGGGAATCGCGGACGCCTCCGGACCGGCCGCGCTTTTCGGCTGCGCGGTCCGGCGGGGGTATCCGCAGGCGGGCTCGCTCTCACCTGAAGCCATTGCCTGCGGGCCGCTTGCTCAAGCGGCCGTGCAAAATATCACACAATTCGACGAAGGAAGCGCGCGGCGACTACGACTTTACGCCTATGCCGATCGTCCGAAATATCCGGATAAATAATTGATGCAGATGGCTTTTGAAGGAGAGGAAGGGGCAAGGACGTGCTTTAACGTTTCAGCCGGAGCGTTCGAAAAGAGAAACATCCGTCAGTCTTCGCGAGGCTTCTTCGCCGCTTCGCGCCGCGCGCGGAAGAACGCCGAGAGCGCCTGGCTGCATTCTTCCGCCAGCACGCCACCCTCGACCATGACCCTATGGTTGAGATGCTCCTGCTCGAAGAATCGCCCACGGCTTTCCACTGCGCCCGACTTGGGCTCGACCGTGCCGTACACCAGGCGCTGGATGCGTGCGTGCACCAGCAGTCCGGAACACATGCTGCAGGGTTCCAGGGTCACATACAGGGTGCTGCCTGGCAGCCGGTAGTTGCCCGCCTCCGCCGCTGCCATGCGGATCGCCAGCATTTCGGCGTGGGCACTGGGATCGTGGCTACTGATCGGCCGGTTGAAGCCCCGCCCGATGATCTCGCCCTCGCGCACCAGGACCGCGCCCACCGGCACTTCGCCGAGGGCCGCGGCCTTTTCCGCCTCTGCCAGGGCCTCGCGCATGAAATGCGGGTCCCGGCTGCGATCGATGATCGGACGCACGCCTTTTACCGTCGGGTAGCCCTTGCCGTTGCTGATCAGCTTAGTCACCCGCACCAGGCCTCGCCGACCGCGATGGTCCCCATCAGGCCGGTCTCCATATGGTCGATGACGTGGCAGTGGAACATCCACAGGCCCGGATTGTCCGCCACCAGCGCCACGCGGGCAGTCTCGTTCTTGCCCAGCAGGTAGGTGTCGGTGAAGTACGGGATGATCTCCCGGCGATCCGAATCCAGCACCTTGAAGGCCATCCCATGCAGGTGGATCGGGTGCTGGTACTGCGCCATGTTGCGCAGCTCGAAGATGTAGCTCTGGCCTTCCTTGAGCTTGGCCAGCGGCGGCGCGTTGTGCTTGTGCTCCTCGCCGCCTTCCCAGGCCTTGCCGTTGATCTGCCAGAACGACGGATAGGGATTCTTGCCGCTGGTATCGGACATCGCCCCGACCCACTCGAAACGGAAACCGATCTTCTCGGCATTGGCCAGGTCCGGTTCGCTCACCGGATTCGCCGGCAACGGCTTCGGCCAGTCGCCGGCAGGTGCCTCGGCGCTGGCCACGCTGCGGATCGTCGCCAGGCGTACCGGCCCGTCGCGCAGGGACAGCTCGGTGCCCGCTTCCGGCACCTTCAGCGCCAGCTCCAGGCGCATCCCGGGACCGATCCAGTACTGCCCCTCGAAGCCGCGTGGTTCCACCGGATGGCCATCGATGGCATAGATCCTCGCCTCGCCGTTGGGCAGGTTGAGACGGTAGGTGACGGTGTTGTCGACGTTCAGCAGGCGCACCCGGACGATCTGCCCGGCCGGCAGGTCGATGGTCGGCACATGCTTGCCGTTGATCGTCGAATAGCGCCCGCGGGTGCCTTCGCGCGCGGCCTGGCGCGGCACGCTGAAGGGGGTGAAGGCGCCCTGCTCGTCCACGTGCCAGGTCTTCAGGCAGAGAACCTTCTCGTGGCGGAACCCGGTGGGTTCGCGCTCCTCGATGATCAGCGGGCCGACCAACCCGCGGCCGAGCTGCTCGCTGCTCATCAGGTGCGGGTGGTACCAGTAGCTGCCGGCGTCCTGGGTCTTGAACTGGTAGATGAAACTCTCGCCCGGCTGCACCGGCGGCTGGGAAATGTACGGCACGCCGTCCATCTCGATCGGCAGGCGGATGCCGTGCCAGTGGATGGTGGTCGGTTCGTCCAGCCTGTTGGTGAAGCGCACCCGCAGCCACTCGCCCTGCTTCGCCCGCAACTCCACGCCGGGGCACTGGCCGCCATAGGCCAGCGCCGGACTGCTGAAGCCCGGGACGATCTCCAGGTCCAGCGGCGCGGCGATCAGTTCGTAGTCGTACTCCTGCGCCACCTGCGGACGCGCCAGCCAGAAGCGCGCGCCGCCGGCGCCGAGGCCGACCACCGCCAGCCCGGCGAGGCCGCCGAGCACTTGTCTACGGGTAAATGTCATGGAGCCTTCACCTTCGCGGTACTGCGGCTGGGAAATGATAGATTTTCTCATTTCCACGCCCACAAGGCGAGTTCTCGCTCGGAACAAATACACTCCCGCTGACCTGCAGCAAGCAAAAGAGCTCCCCAGCGCCAGCGGCGGATCGCTGGTCGCGGACTACGCTCAGGCTACCTTCACGATGCGCTTGCCGAAGTTCTCGCCATTCAACAGGCCGACCAGAGCCGCCGGCAGGCTTTCCAGCCCGTAGAGCACATCCTCGTATACCTTGATCTGCCCGGAGTCGACCCATGCCTTGAGATCGGAGAGCGCCCGCTCTCTGCTCTCGAGAAAGTCGCCAAGAAGGAATCCGCGCAACGTCAGGCGCTTGATGATGAGTAGCCCGGGGATCCCGGCAGGACCGGCGGCGGGTCGGTCCAGGTCGTATTGCGAAATCGCGCCGCAACAGGCGACCCGTCCATGCTCCGCCATGTTCGGCAGGCAGGCATCGAGGATTGCACCGCCAGTGTTGTCGAAATACGCGTCGATCCCGTCCGGACAGGTCCGCCGCAAGTCATCGGCCAGCGTCCCCGTCTTGTAGTCGAGTGCCGCGTCGAAACCCAGTTCACGAACCAGCCAGGCGCATTTGCTGGCGCCTCCCGCAATGCCGATGGTACGGCAGCCCCTGATCCTGGCGATCTGCCCGACGATAGAGCCGACGGCACCGGCGGCGGCAGACACTACCAGCGTTTCGCCCTGCACCGGCCTGGCGCATTCGAGAAGGCCGAAATAGGCCGTCAGGCCTGCTACGCCGTAGACGCTGAGCAGATGCGTGAGGGGCTCCAGGCGCGGCAGCCTGATGAGCCCGGCCGCCGGCACGACCGCGAAAGTCTGCCAGCCGGTCTCGGCACAGACCAGGTCGCCGGGCTGGAACGACGCCGAGCACGATTCCACCACCTCGGCCAGTCCCAACCCCGCCATCACCTCCCCGGCCACGAGGCCGGGGCGATAGGTCGCGCCTTGCATCCAGGCCCGGCTGGCGGCGTCCAGCGGTATGTACAGGACACGAAGCAACAGCTCACCGTCGGCCGGAACCGGACAACGCACCTCGCGCCCCTGAAAATGCCGGACAGCGAGCGCAGTCCGGGGAAGCTCGCTCAGAACGATCTGACGGTTGATCATCGCTTCTCTCCCGCCGCGAGAGCGACACTGTCGCTGGCCTCACCGCCGAAAGCGGGAGGCATGTGAAACTGTCTGTCGTGCATGCTGTTCTCCGAGTCGATGGCAACCTGATGCAATCTCATTGTGAGAAAACATCTCCGGACTTAGAATGCAAAAAACTCCTATCTTCTATCGCGATCGTCCAGCATCAATGGATCCTCTCTCCGAAGTCCTTTCCCTGGTCAACAGCCAGGACTCCTCCTTCGGCGCCCTGAAGACCGGCGGCGATTGGGCACTCCGCTTTCCGGCACCGGAAGGTGTGAAGTTCAACGTGGTAGTCCGTGGCGCTTGCCTGCTGGCCACCGACGGCATGGAAGAGCCGATCCGACTGGAAGCGGGCGACTGCTTTCTGGTGTCCTGCCGCAGTCCGCTGCTGGTCGGCAGCGATCTATCCCTTCCCGCCGCCGACGCCACGCTGCTCTACCGAGATGCCCCTGACGGCGTCGCGCACTATGGGGAAAGCGAGGATTGTTTCCTGATCGGCGGTCGCTTCGCCTTTGGCGAAGAAGCCAACCTGCTGTTCGACGGGCTGCCTCCGGTGACCGTCGTGAAAAGCGATTCGGACCAGGCATCCGTACTGAGCTGGGCGCTGCACCGACTGGCCCATGAGTTTTCCTGCCCGTCACCCGGTAGCGCGCTGATCGCTCACCACCTGGGCCACATCATGCTGGCGCAGGTGCTGCGCCTCTATCTCGCCGGCAAGGGCAGCGACACGCCCAGTTGGCTGCTGGCGTTGTCCGATCCGCGCATAGGCGCGGCGATCCGGGCGATCCACGCCGAGCCGGCCAAAGTCTGGACGGTCGAGCGCCTGGCCGACGTAGCGGGTACCTCGCGCTCCACGCTGGCCCTGCGTTTCAAGCAAACCGCGGGACTGGCGCCGCTGGAATATGTATCGCACTGGCGTATGCAATTGGCGGCTCGCGCCCTGCGCGACAGCAAAGCGACGATTTCCTCGATCGCGCAAACCCTGGGCTACGGCTCGGACAGCGCCTTCAGCAACGCCTTCAAACGCATCATGAAATGCTCGCCCAGAGACTATCGCAGCCGGCAGGCCAGCAGGGCATAGCGCTCGGCGAACCGCCCATGCGGCAGGTTCCCCGAGCGGTCGAGCGCATGGTCAAACGACCGACGGAGCTTGCCACGGTATCTTTCCCGCCCGAAGGATGATCCCGATGGCCAGGACCACGCACGCGCCGAAGGCATAACGCAGGCCGAACGCTTCGGAGAGAAAGCCGATCAGCGGCGGGCCGATCAACGTGCCCAGGAATCCGATCGTCAGAACGGCTGCGATAGCCGAACTCGGCGCCATGCTCGAGGAGCGGGCGGCGGCCCCCGCCACCAGCGGAATGACGGTACAGATGCCGAGACCGACAAGGCAGAAGCCAATGATCGACGCCAGCAGGCTCGGATAGGCGATCGTCGTGACCATGCCGATCAAGGCGAGCCCCCCGCTCCACTGCAAGGTGCTGCGCGTACCGAAACGGTCGGCGACTCGGTTCAGCAGAAGCCGGCCGACAGTCATGGCGCCCATGAACACCATGAAGCCGACTCCGACCAGTTGCCGCTCGGCCGAGACCACGTCCTGGAAATAGACGACGCTCCAGTCATACATGATGCCTTCGCAGGCCATCGAGAAAAAAACGATCAGCCCGTAGTTGAAAAGCCTCCTGTCCGGCATCGTGAAGGCCCGCCCGACCCGCTCCGCGCCAGGCTGGTCGTGGAGAAAGCGCCAGCAGGCCAGGGCGGCCAGGAAGGCGATCACCGATATCACGCCGAAATGCGTGGACAAGGCAAAGTCCTGCCCGATCATCAACGCCCCGAACCCGGCGCCGACGAATCCCGCCAACCCCCATATACCGTGGAAAAACGGTAACTCGGTCTTTCCGATGAGCGCCTCCGACAGGCTTGCCTGGGTATTGTTCGACACATTGACCGCGCTATAGGAGAACCCCGATACGAACAACAGAGCAGCAAGCTGGTAGACGCTAGAAGCCAAGGGAACCAACGACAGCAGAACGGCGTTCGCGAGAATCGCCGTTACTCCAACGTTTCTGCTGCCGAGCTTCGCGATCATCCAGCCGGATACCGGCAACGAGAGCACCACCCCGGCCGACATGGCGAAAAGCGCACTGCCGAACACCCCGTCGGAAAGCTGGAGTCCGTCTTTTATCGTGGCCATCCGGGAGCTGAGGCTCCCGAAACACAATCCGAGCATGAAGAACATGCCGGAGATGGCAATACCTTTCCCTACGCTGCTGGAGGTCATTCGATCGATCCCGGTGCTTGTTTGATGGACAGAAAGCGCGGTATCCGCGACGTCTTCCGTGTGCTCGACTAGGACGCGAATGCGTCGATCCCGGTGAGCGTCGCCGAAAGCCTCCAGAGACGGCGGGCCTGCTCCGGATCGATCGCATGCTCGCGTACGCCGGCCAGGGTGCGCGAGTCGTCCGGCGCGATGCCTGCGATGTCGCAATCCTCGCAGTAGAGCCCGCCCATCCCCGCCAGCAGCGGAGAGGTCGCAGCCCACAGCTGGGTGGCAGCCCCCTGCTGCGGGGTCTTGAGCGTGTCGGGGCTGGCCGGATTGCCGGCTTCGTCCATCCAGCCCAGGGCGATCATCTCCGCCCGTGGAACATGGCGTTGCAACGGTGTGGCGATGCTGCCCGGATGCAATGCGAAGGCATGCACACCCCTCTCGCGACCCAGCGCATCCAACTGGATGGCGAACAGGGCGTTGGCAGTCTTCGACTGCGCATAAGCCAGCCACTTGTCGTAGCCCCGTTCGAACTGCACGTCGTCCCAGCGGATCGCCGAGTAGCGGTGCCCGGCGGAGGACACGGCGACCACTCGCGCGTCATCCGCGAGCGACGGCCACAAGAGGTTCACCAGGGCGTAGTGGCCAAGGTGATTGGTCGCGAACTGCGCTTCCCAGCCCGGGCCTACGCGGGTCTCGGGACAGGCCATCACACCGGCGTTGTTGATGACGATATCGGCACGACGGCGCGAGGCGGAGAAGGCCTCGGCGAACCGACGCACGCTGGCCAACTCGGCCAGGTCGAGCGCCTGCACCTCGACTTCGTCGAGCCCGAGCAGCGCCTCCCTTGCCACATCCGGTCTGCGCGCCGTAACAATGACCCGCGCGCCCGCGTCGGCCAGCGCCTTCGTGGTTTCCAGGCCAAGACCGGAGTAGCCGCCGGTCACGATGGCGGTCTTTCCGGAGAGGTCTCGCCCCGCCATCACCTCGCTGGCCTGCGTTTTCGCTCCGAATCCCGAATTGATGGGGGTTTGCCTGATAGCCATGAGAACTCTCCTCGCATGCGGAAGCGGCCAGGCGGATAGCGCTGGCTCTTGGGACGAGGGTCATTATCGAAGTGGAAAACTGGATTCCGAATGCAGCGGAATCCAGTTTCCTATCGAGATCGTCCGATCCCGTAAGCAGCTGTTTCATCACCGCTGCAAGAAAAGCACGGGACGGCGCAGAATTTGCTGTACGTTGGCGAACTCGCCAACAGCAGCTGAAGCAGGAAAAATTGATATCAACCCCAGGGCCTACTAACTAGGCAGCTGTACTAAAACTGGGGGCAGGTCACTCCACCGAACACTTCCGGGAAGGCATGGAACACAATGACGGAAAGCACCGCCACTGCGCGCAAGCCATCAATATCAGAGCGATACTTTGGTGGATAACCGTTCGACATGAGCCTGACTTGTACTTGCTTGTTGAAGCCGCTCCCTCGCTTGCTCGGGAATAGGTAAAACCACAGAAGCTTCCGCCGCCGAGCGAAGAAAATCGATGGCTAACATCACAAATTCGCCGGCCTGCCAAGACGCATACATAGAAGACGGCGACCTGTCGGCCACCCTGCCCCATGTGCGTCTCTACGACCAGTAGTCGCTCCGCCCAGTTCGTGGGTAACTTGCTGGCGACGCGGAAATGGCTCAGCCCTTGCTGAGCAGCCTGGCCACCAAACGGCGATACCCCGCCAGAAGCGAAAATCTGTCCTGGTAGAAATCGAGGATCATGGTTTGCCCATGAATGTCGATGGTATGCGGACCGCGTGCGTCCTGGAACGCCAGGTTTGCTACACGCTTCTCCGAATAATGCTCTGGATCGAGCACCTCGATTTCGTTTACGGCCAGACTGCTTCCATAACCATAGGAGTTGTTCTGACCGAACCGGTAAAGCTTTCCTCCCTCCTTGAAGATACGCCCGCCCATTCGTGCGGAGCCGGGATTCATCACCACAGGGTTACAGGGATGGGAAGTGTAGGGTCCTTCCAGGCTCTCGCCGACATAAAGATAAAGGTTGTCCGAACCTGATACCGCCTGGCCGCAGAACAGGTAGTACCTGCCCCCGTGTTCGAAAAGCGTGCCATCCAGAATCCGCTCACCCTCCATTCCCTGGAATAGCTTCTTGCTCTCCAGAGCGAAAGGAGGAGGCAGAAGACAGGGAGCGGAATGAGAGGCGACTTCCGGTATCAGATATTCGACACCAGACGCCTCGAACGAATAGGGATAGGAAAAATGATTCCCCTTCAAGATCACACGTGAAAAGTCAAGACTCTGGGCCTTCAATTCAATGATTTCACCCAGACCGTTGCTAGCATTCAAGGCTTCGAGACGTATCAGCTTACCGTCCGCACTAAAGAAAGGATCGGCGTAGAAAGTATACCCCTTCTCCACCTTCGGAATCTTTCCTGCTGAGACGGACAATTCTTGCAACGAAGGAATATCGTTGTAAGGAAGCGCAACGACATTCCATTTTTTTTCGAAAAACGCCCCGTACGATAGCCGGGCAAGCCCCCGGAAGATAGTCTTGCAGAAAAACTTGAAGACGGTGAAATTGCTGGGCAGACGGTAGTTTTTGCCCAGCTTTTCTAATACCACCTGCTCTCCCCGAGAGTAATTGACAAGCGCCTTGCGAAGCAGCACGACCGAATTCAGATAAAAGTTTCTTGAGGTTTTCTTGTAGGAGTGGTGATGAACCTTGGAGTACCCGCGCACCAAGACCTCGCCGGCGTCCAGTTTGTTGGAGAGCTTCTGGACTATGATCCCGACGCTGTCTGCATTTTCATAGATCTCATAAAAGCCCGCGGGCCGCCCCCTGTAGTACTCTGGATCGCCATGGTGGTAGGAAAGAATGTCCAGCCTCTGCAATCCTCCATCGATGCGGAGCAGAGACATGCCAAACTTGATGACCAGCTTTATTCCCTTATCCAGAATTCGGGCGCAGACATCTTCCGGGATGCGCTGCCAGGCCCCTTCGTAATCAGAATCGAAATGAATGACTTCTGAGCCACGAGAGTCTAACTGCACTCGACGAGTCATATCATTCTTCAGGGAAAGAATATTGAGAAAATAATACCCGCAATGCTTGATGACACTTTTCTTGGTCGCGCTATTACGACAACTGAGAACCAATTGAATATCAAGATACTCAGAAGAGTCTTCAATCGCCCGCTTTTGCCACTCACTCAATGAAAGATCATCAACAATCAACGCGGCCTTTATTTTCATCCCGAAACTCGCCTCTGAAACAATGAAACCCCAAAAATGCTGCGAAATTTCGACAGCCCCGAGAAACCGACACTTTTCACTGAAAAGCTGCCATGACAATTAGCAAAGCATCATTAAAGCGAAGCAGTATATCTCATGATCGACGGGCCGATTCAACCGTAAAACGGCCGTTAAACAGTTGCTGGACCACCAGCCAACGCTATACAGACATCATTTGGCGGAGCCACAAGGCTTTCGGCGGAGCCATAAAAGACAACGGCCTTACGGCCGTTGTCTTTCGGATGAATCACCAGGGAAGAAGTGGCTTCACTCCCACTCGATAGTCGCCGGCGGCTTGCTCGACACGTCGTAGGTGACCCGGGAGATACCGGCAATCTCGTTGATGATGCGGTTCGAGACCTTCTCCAGCAGTTCGTAGGGCAGGTGCGCCCAGCGCGCGGTCATGAAGTCGATGGTCTCCACCGCGCGCAGGGCGACGACCCAGGCGTAGCGACGGCCGTCGCCGACCACGCCGACCGATTTCACTGGCTGGAACACCACGAACGCCTGGCTGGTCTTGTGGTACCAGTCGAAGGCGCGCAGTTCCTCGATGAAGATGTGGTCGGCCTGGCGCAGCAGGTCGGCGTACTCCTTCTTCACCTCGCCGAGGATGCGCACGCCCAGGCCCGGGCCGGGGAACGGGTGGCGGTAGACCATGTCGTAGGGCAGGCCCAGCTCCAGGCCGATCTTGCGCACTTCGTCCTTGAACAGTTCGCGCAGCGGCTCGACCAGTTCGAACTGCATGTCCTCCGGCAGGCCGCCGACGTTGTGGTGCGACTTGATCACGTGGGCCTTGCCGGTCTTGGCGCCGGCCGACTCGATCACGTCGGGGTAGATGGTGCCCTGGGCGAGGAACTTCACGTCCTGCAGCTTGGTGGCTTCTTCGTCGAAGACTTCGATGAAGGTGCGGCCGATGATCTTGCGCTTCTCTTCCGGGTCGGCGACGCCGGCCAGGCGGCCGAGGAACTTGTCCTCGGCGTTGGCGCGGATCACCTTCACGCCCATGTTCTCGGCGAACATGGCCATCACCTGGTCGCCTTCGTGCAGGCGCAGCAGGCCGTTGTCGACGAACACGCAGGTCAGTTGGTCGCCGATGGCCTTGTGCAGCAGCGCGGCGACCACCGAGGAGTCCACGCCGCCGGAGAGGCCTAGCAGGACCTTGGAGGAACCGACCTGGGCGCGCACGGTGGCGATGGCGTCGTCGACGATGTTCGAGGGGGTCCACAGCGCGGCGCAACCGCAGATGTCGAGGACGAAGCGCGAGAGAATGCGCAGGCCCTGCTTGGTGTGGGTGACTTCCGGGTGGAATTGCACGCCGTAGTAGGCGCGGGCATCGTCGGCCATGGCGGCGATCGGGCAGCTCGGGGTGCTGGCCAGGATGTGGAAGCCGGCCGGCATCTCGGTGACCTTGTCGCCGTGGCTCATCCACACGTCGAGGCCGAGCACGCCGTCGTCGTCCACGTGGTCCTCGATGCCGTCCAGCAGGCGCGCCTTGCCGACCACGTCGACGCGGGCGTAGCCGAACTCGCGCAGGTCGGAGCCCTGCACCTTGCCGCCCATCTGCTCGGCCATGGTCTGCATGCCGTAGCAGATGCCGAACAGCGGCACCTTCAGGTCGAACACCGCCTGCGGCGCGCGCGGGCTGTCGGCTTCGTGTACCGACTCGGGGCCACCGGCGAGGATGATGCCGCGCGGCGCGAAGGCGATGATCGCCTCGTTGCTCATGTCGAAGGGATGGATTTCGCAATACACGCCGATCTCGCGCACGCGGCGGGCGATCAGTTGGGTGTACTGGGAGCCGAAATCGAGGATCAGGATACGGTGGGCGTGAATGTCTTGGGACATGGCCATCTCTCGCTACGGAATTCGAAAACGACACGGGGCTGAATCGAACAGCCCCGTGCAGCACTCATTTCAATCAGCCTCAACCAACCCGGTAGTTGGGGGCTTCCTTGGTGATCTGGACGTCGTGGACATGGGACTCGGCCATGCCCGCGCCGGTGATCCGGACGAACTGCGGCTGCGTGCGCATCTGCTGGATGTCGGCGCTGCCGGTGTAGCCCATGGCGGCGCGCAGGCCGCCCATCAGCTGGTGGACGATGGCGGACAGGGCGCCCTTGTACGGCACGCGACCCTCGATGCCTTCCGGCACCAGCTTCTCGGCGCCGGCGGAGGCGTCCTGGAAGTAGCGGTCGGACGAGCCCTGGGAGCCGGACATGGCGCCCAGCGAACCCATGCCGCGGTAGGACTTGTAGGAACGGCCCTGGAACAGCTCGATCTCGCCCGGCGCTTCCTCGGTACCGGCGAACATCGAGCCCATCATCACACAGTAGGCGCCGGCGACCATGGCCTTGGCCAGGTCGCCGGAGAAGCGGATGCCGCCGTCGGCGATCAGCGGTACGCCGGTGCCTTCGAGGGCGGCGGCAACGTTGGCGATGGCGGAGATCTGCGGCACGCCGACACCGGCGACGATGCGGGTGGTGCAGATCGAGCCCGGGCCGATGCCGACCTTGACCGCGTCGGCGCCAGCCTCGGCGAGGGCCTTGGCGGCCTCGGCGGTGGCGATGTTGCCGCCGATCACCTGGACGTCCGGGAAGGTCTGCTTGACCCAGCGCACACGCTCGATCACGCCCTTGGAGTGGCCGTGGGCGGTGTCCACCACCACCACGTCGACCCCGGCGGCGACCAGCGCGGCAACGCGCTCGCCGGTATCGGCGCCGGTGCCGACGGCGGCGCCGACGCGCAGGCGGCCCTGCTCGTCCTTGGACGCCAGCGGGTAGGTCTTGGCCTTCTCGATGTCACGGAAGGTCACCAGGCCACGCAGGTAGAAGTTCTCGTCGACCACCAGCATCTTCTCGATGCGGTTCTCGTAGAGCTTGGCCTTCATCTCTTCCAGCGGGGTGCCTTCGCGGGCGGTGACCAGCTTGTCCTTCGGGGTCATGATCGCGGCGACGGTATCGCCGGCGTTCGGCTTCACCCGCAGGTCGCGACCGGTGACGATACCGACCAGCTCGCCCTGCTCCACCACCGGGAAACCGGAGAAGCCGTACTCGCGGGCCATCTGCAGCAGTTCGATGATCTTGGTCGAGGGGGTCACGGTGACCGGGTCGCGGACGATGGCCGTTTCGTGCTTCTTGACCTTGCGGACTTCCGCGGCCTGCTGCTCGATGCCCATGTTCTTGTGGATGATGCCGATGCCGCCTTCCTGGGCCATGGCGATGGCCAGGCGGGCTTCGGTCACGGTATCCATCGCGGCGGATACCAGCGGGATGTTCAGTTCGATGCCGCGGGTCAGGCGAGTTTTCAAACTCACGTCCTTGGGCAGGACTTCGGAATAACCGGGGATCAGAAGGACGTCGTCGAAAGTCAGGGCTTCTTGACTGATTCGCAGCATGGCGGGCGCTCCCAGACGGGAAAAATGGAAGCGCGACATTATACCCAGCCACGGGCTTCCGCTCAACGCAGTTGATCGCCGAAAACGGCGAATGGGCAAATATCTTGCAAGGCGCCCGCCAGGCCCCGTTCCGCCTGTCCTATCCCGCATTTGCAGGATGGCAGCGCGGCGGCGGATGGCCGGATACTGCGTACGTCACCCAGCGACCGCCCAGGCGGCGGGACGCCGATTCCAAGAACTATAAAAGTGGGACGGGGGAGAGAATGAAAGGGAGCACTGACCCGCATTCGTCATCCGCAGCCTTGCTCGCGGCGTTCGGCGCCGCCGTGCTGGACATCAACCGGCTGGCGCGCGACAAGACCCTGGAGCGTTTCCATCGCACCGCGCTGGAACGTCTGCAGCAACTGGTGCCGTTCCAGCGTGCCTGGTGGGGCCGCGCGGCGCTGATCGACGGCGTGCCGGTGGAGCACAGCGCACACCTGTTCAACCTCGAAGAGCACTATGTCGAGGACTGGAAATCGATCAGCCACGACGACATCACCGTCGGACTGGTACA
+>6_1#NODE_3_length_40000_cov_63.0619_ID_5
+CATATCCCCAAACTAATTCTAAAAGCTTATCTCTTGAAAAAACTTGTTTTGGTTTTTGAGCCATCGTGTAAAGTAAGTCAAATTCCTTTGGAGTTAAGCCTTCAACAATATTATCATCAAAGCGCACTTCTCTTCGATCTTTTGAAATCTTTAGATGCTTAGTAATTACATCATACTTTACGCCATTAGAAGCATGCATATCTTTTTCTATACGACTTCTTCGATATAAAGCTTTAATGCGGGCAATTAGTGCTAATGGACTGAATGGTTTAGTAACATATTCATCTGCACCAATGCCCAAACCCAAAATTTGATCAGTTTCTGAGTCACGTGCAGTTAACATAATGATTGGTATTGAAAGAGAAATAGCCCTTATTTCTTTAGCTACTTCCATTCCATCCTTTCTAGGTAAGTTAAGATCTAACGTTACAATGTCATAAGAATCTGGATGCGCTTTAAACATCTCAACAGCTTCTATACCATCCTTAGCTATATCTACTTCCCATTGTTCTTTACTGAAGAACATCTTCATCATTTCTGCAACAGAATTGTCATCTTCAACCATTAATATCTTTAGCATTATTTATCCTTAAATCCTTTTACTCTAGTATGTTTAATTTTATCTGGTTCAATATAATCATGTGGTAATTCATGCCGGGCACGTAAGAAAGCCTGCAATTTTTTCTCAGTTAAGATTATCGGAGCCAAAATAAACAAATAAAAAGTAAGCAACCAGATCAAGAAATAGCGATCCCAGTGTAAGAAATGAATTCCTAATCCCAATAGAAATTGAACTAAGCCAAAAATCATGAAATAATTTCGTGCAACTTTTTGCGCATACTTGTAACTTGTTTCATTAACTGAAGCCAAATACGACATATATCCATAAACTTGATTCGGATTAGGTGAAGGAGCGATCAGCCAAATGACTCCGATTACAAACATTATTACCCCGCAACCAATATATATCATTTGACCAACTCCATTCACTTAAATTTATTCTTTACCAGGAGCTGAAATTACTAAACGTAAGTCACCGCTAAAACTAAAGTTCTTCATCTCATTAGGAATAATAAAATTAGTACCCAATTTGATATTATATTCTTTACCGTCAGCAATAAACTTACCTTTACCTTTAATTACAGATACTAAAAGATAAGGATGATCATTTAGACTCCAATCAAAACTCCCATCAACATCGATCTGCCATAAATAAAAATGCGGTGACATTGGTGGTTGAGCTAAAGTAGTAATCTTTGCATCTCCCAATGTTTCAGATGTAATTTTCAGCTTCGGATCTTTATGTGGTACTTGAATAGTATCAAGAGATTGTTTAATATGCAACTCTCTCTTTTTACCAGTTTTCTTATCTACTCGATCCCAATCATACAATCTATAGGTTACATCACTTGATTGTTGTGTTTCAATAACCATAATTCCTTTAGTTAATGCGTGAACCGTTCCAGAAGGTACATATAAAAAGTCTCCTTCTTTCACTGGTACATAACGTAAAAGCTTCGACCACTTTCCATTTTTGATCCAATCTTCTAGTTCTTCTTTACTAGTTGCATTGTGCCCATAGACAAGTTTAGCACCAGGTTCGGCATGAAGCACATACCAACTTTCAGTTTTTCCAGAATCATTTTCATGAATTCTAGCGTATTCGTCATCTGGGTGTACTTGAACAGACAAATTATCATTTGCATCTAAGAATTTAACTAATAGTGGAAATTCCTTAGCCTTGGGATTACCAAATAATTCTGGATGCTCTAAATATACTTCTCTTAACGTCTTTCCTTTTAATGGACCGGCATTAACTGTCGAAGCGTCATCTTTGTATCCAGATATTACCCAAGCTTCTCCAACTTTTCCATCTGGAATATCATATCCTAAAACTGTATTTAACTTACGTCCACCCCAAATTTTGGGTCTGAAATATGGTGTTAAAAATAATGGTTCCATAAAAAAATCACCTCAATAAAAGTATATATCTTTTTTAGATGATTTTGAAATCGATTTCAGCTATTTTTTTGAATATTTTTTTATTCCACTAATTAAACGTTTAATTCCATCCTCTACCATAGAAATTGGTGAAGCTAGATTAAGCCGTAAAAATTTATTACCATTACCGCGATAAATACTACCAGGTGAAACAATTAGACCAGTTTCTTTTCTAATATAATCAGCTAATTCTTGACTATTTGACGAAACTTTACTTACATCAAGCCACAACAAGTAAGTTGCTGGACCTGATACAATTTTTACATCTTCCAGATTATTAGTTATTTCTTTTTCAGCATAATTAAAATTACGATTAATTATCACTAACAATTCATGTAACCAGCTAAAGCCTTCAGTATATGCAGCAATTGTTGCTGGAATAGCTAAAAGATTTGGCTCAGCCAATTCATCGCTGTTAAGACCTCGATTGACGATATAACGTAAATTTTCATCTGGAATAATTACGGTTGCAGCATGAAGAGCAGCTACGTTAAAAGTCTTACTTGGAGAAACTAAACTAATTATATTATCCCTCAAAGCTTCAGAAACTGAAAATGCAGGGGTGTATTTAACGTTATCTCTGACCAAGTCTCCATGAATTTCATCTGATAGAAGAATTACGTGATATTTTTGACATAAAGATGCAATTCTCTCTACTTCCGTAGGTGTCCAAACTATCTTTACCAAAATAATCACCATTAATTTCAGCATTTTTAATTTTGACGTCCTCACAAGTCCACATTGTTTCTTCTGCATTAGAAAAGAAAACATGATCTAATGAAATATGCTTACACCGTCTAAATAACTTAGGAGCTTGTAAATCTGAATTTTTAATTGAAATATTATTAGTATACCAAATACCGCTTCGCGACATTGTTTCAAAGGTACTGTCAGCAACTTTAATATTATTCGAATACCATAAAGGATATTTATATTTAAAAATAGTAGATTTTATTTCTAAACTTTGCGTTTCTTTTAATGGTGATTCTCCTTCACCAAAAGTAATATTCTCTAAAATTGTATCCGAAAGGCCATATAGCGGTCTTTCTCCTTCAAAATACTTTTCTTTAATTATTTGCATAGATTTCCTCTTTTATTAACTCTTTCAATATTTAGTCTAAATTATGAAAAATAAATGTCTAATATTTGCTAACTATAACGAAATATATTTTTATGCTATAGATTAGTTTTGCACCAAGATTACTTTTCAAATTTATTATAGAAAAAATAAAATTTTGAGAAAATTTACAGTTTTTCATACTAGAATAAATTAAATTTATAGCAAAAAAAGGATGAGTTTCAAAGCTCATCCTTTTTAATCAATTTAGTTATTACGTTTACGCTTAGAAACACCAGCTAAGCCGATAACGCCAAGCATTGAACTTACAGCACCTACTATAGCTGCAACAATACCATTTTTAGCTCCAGCTTTTGGAAGTTCTGATTGAGTTGTCTTCTTAACTGAAGTTGTTGGAACTTCTGAAGTTGGTTTAGTTGGATTATGCGGAGTATCAGGAGTATTTGGTGTTGTTGGTGTATTAGGTTTCTCTGGAGTAGTTGGAACATTTGGAATTGGAGTTACAGGTTGATGTGGCTTCAAGTTATATCCACCGATTAAGTCCCAATCAACTGGTTTGCCCCATTCACCAGGAAGAGCAGCACTATTTGGTGCATCTTTTTTAAGAACACCCATCATATCATCGTTTTCGCTAGTGTCATCCCAAATCCAGTCACCTTGGTTAGTCATTTTAGCTAAAACAGTAGTAGTATTATCTGGATTAATTTGTAACAAGAAACTTGGTGCCCAAGTTGCGTGCATACCCTTTCCAGCAACTTCACCACGGTTAGTGATATAAGAAGTAATCAATAATTGATCATCTCTTCCTTCTACTGGAACTGCATAGTATGAGTAAGTTGCAGTACGCCAGTTTGCTGGAACAGAAGCAGTTAAAACTACTCCAGATTCATTTAATGGAACGTATCCATGAGTTAGGTTATCAGAAACGTAACCAATCATTGCAACGTTATCACCAACTGCTTTATTAGCAGCCATCCATGCATCGTCGTTACTTCCACGGTTTAATCTAGTAGCAGCAAATAAGTAATACTTGTTGCCCAAACGAACTACATCAGGACGTTCAATTTCATCACTTACCATTGGAGAACTAATAAGTGGTGTGTAGACCTTCTCAACACCAGGGTTCTTAGTATCATTGTTTAACTTAATAATACCGATTGCAGCATTAGACCATTTTGCTCTATCTTTAATATCAGAGTTAGACAAGATTTGGAAGAAATCACCTAAATTATCTTTGTTAGTGCCACCGTAATTTAACCATTGATAAATTTGGTCAGCACCTTGATAATTCTCTGTACCAGTACTTGCTTCAAAAACGATGTGGTCATTATCGACGTGTGCAATAGAAATCTTGTCTTGATCCTTTTCAAGATTTAAGTAGACAGTTGCACTTGCAATCTTTTGGTGGTTAGTGTTGTTATCACTTGTATCAACCTTAGTATAGTAAAGTTGGATTGAACCATCTTTATTTAAAGTTGCTGAGCCAGACCATTGTTGAATAACTGGAGTACCTAAGCCAAAAATAGGACCAGCATTCTTCCAATTATTAAAGTTATTGTCACCGTACTTGTTGTAAAGAAGATAAATATGATTGTCATTAGTATTTGGAACTCCCATCATTCCAACTACTAATTGATAACCATTCCAGTTAGAAACATAACCAGTTTTGCGTCTTGAACTGGCCATGAATCCCAAATTTCTAAGTCTTCTACTTTTCCTGTTTGGGCATCCATAGTTTTTGCTGCAGGCATGTTCTTAATTTTACTTGCATTAAAGAAAGGAATAGCGTAACGAGCATCTTGTTCAATTAAAGTTTTAGCAATTTTCTTAAAGTCACTGTAAGTTAATTGAGTACCGCTCTTTGCTTCTTTAGAAAAGTTAATCTTATTTAATTCATTAATTTGATCATTGGTTAATTTACTGGTATCTACATCAGATTCTTTAACAATATCTTTAATTTGACCCTTTAATTCAGCTTTGTTATCGTTTGATGCTGTTTTTGTTGAAGTTTCGTTAGCTTTTTCTTCAGTATTTGTCTTAAATGAAGTAGCTGCTTTTTCATCTTGTTTTACTGCATCGTTCTTTTTAACATCAGCAGAAGAATTAACAGGTGTCTTCTCAGTACCATCTACTGTTTCTTTAGTAGTTGTTGTAGAGGTGGTAGCAGCTTTAACATTATTTACTGGTGAAGTATTAACAGCATCTGCTTTAACTTCTTTAGTTGCTGCTGAAGTCACAGTAGTAGCTTTTTCTGCTTTAGTATCAACACTCTTTTCTGAGCTTGAATTTACTTGATTATTATTTTTATTATTTGCTGAAGTAGTAGTACTTACTGCTACAGTTTTGTTTTCATTAACGTTGTCTGCATTAGTAGTAGCAGCATTTACAGTGGAAGCACTTAATACAATTGCTGCTGTAGACAAGGTTCCCATTAATAAAGATTTTCCGCTTAAAGACATCTTCTTATGATTTTTATTTTCCAACATCTTTTCTCCTCCTACATGCTAAGCGTTTAACATTTCATCTTACAGACTATCACCTTTTGTTATAAAAATAAATATTATTTTAAAAAAATTGTATAGATTTGGCAAAATTTACTGTTTTTGTATTCAATTGCCACTTGTCAATCGTTTATCACATTAATACTAAAAAAGCCACACCAGATAATTACTCTAGTGTGGCTTTTCCAACTATTTATGGAGATGAGGGGGTTAGAAATTTACCCTTGCAAGTCCTTTAATATCAATGCTTTTAGCTATTTTAACTTTTACGTGAAGCCCAATATGAAGCCTTAAGATTGCATGTAATTAGCAAAGTTGGTGGCTGTTTCTTTGGCCTTATCCTTAGTTACATGAGTATATATATTCATAGTTGTAGTAATATCTGAATGCCCTAGCCTGTTCTTAACATCTTTCATAGATACACCAGCATCAAATAATAAGGAAGCGTGTGTATGCCTGAACCCGTGAACCTTAATCCGTCTTAATTCATACTTATCACAAATTGCAATATTCCAACGACGTGGCTTAGATAATGCTGTATGTTCTCCCTTAGTATTAGCAAAAACTAAATTACTATCATCTAAAAAGTTTAGTCCAAGTTTAAACATTTCTTTCTGTTGTTCTGTTCTCCACTCTTTCAAGTAATTCATTGTTTCGCTATCCATATCTAGCACCCTTACACTATTAGCCGTTTTTCCTGGTGTTATGATTAGTCGATTATTTTCACCCGATGATAAAGACTTATCTATATTAATGGTATTATTTTTAAAATCAATATCAGCCCATGTAAGAGCTAGACACTCACCGCGTCGCATCCCTGAATAGGCAAGCAAGCGAAAGAACATAAAATATTTAAAATTATATTCTTTGGCATCTTTCAAAAAGGCTTTTAATTCTTCCTTACTATAGTAATCAGTAAACTTTTTATTATCCCTTTCAATTTTTGGTATTCTTACCTTTTGCATTGGATTTCTTTTAACTAGCTCCATATCCATTCCATACTTAAGTAATTTTGAAGTATAGAATTTGAACCGTTTAAAAGTCTTAGGTGCTTGCTTAGACCATTCATTTACTACCTTTTGACATTCAGCAACGGTTAATTTATCCACGTAGATATTACCTAAATCTTTTAAAATATGGTTCTTGAATATCTTTTCAGTGGTCACGAAAGTACTTTCTTCTACTTCCATGCGATACTGTTTAACCCACATATCATGCAAATCTTTAACCCGTAGCTTTTTTTGTTCAACTGGTTTATACTCACCTTTAAGAACTTTCAATTTATAATTCATAAAACACTCTAAGGCTTTATCTCGACTGGTAAAGCCTTGTTTTTTTATCTGGATTGTATGCCCTGTTTTTTCATCCTTACCAGCATAAATTAGAAACTTATATCTTTTCTTACCACTTGGTGTGGTATATTCCTTAATTTCATCATTCATGTTAAATTTACCTTTCACTAATAAAAGGCGTACTGATTGGCTGATATTAAACATTTAACAAAACTGTGGAAGTTATAGGAATAATTCAAATGATTAGCTATTAGTAAAGATGATTTAAATGGTCTTAGAATTGCAATCTCAGCATTAACAAGGGAACTCATAAGTTACCATGTACATTTACACTTTAAGGTGTATTTGTAACTACACGTTGATAGCCTGTACTTTTAGGTACTCCCTACCAGCATATGTAAAAGCATGGAGGGATGTCCGTAACTGTAGTTACACTCATAGATTATACATATGCAGTTACAACTGCGGTTGTTAATTCCTAAAGGGATGCTAGCAAGCCAAATTATTATTTAACCACCACCCTGATTCAGGTTACTGGTTTGAGGGATGAACTAAGCGCTCAGCCCCTGCACTACCGAACTAGTACCGCAGATTAGGGATGCTAGTTAAACACGTCCACAGGGAGTGTTATATATATTTTTGATTTATTGCAATTTGTCCTATTTCATTTTTAGCATTAGTTAACGCATCAATTATTTTATTATATGCTTGCTCATCCATATCCTTACGAACTTTAAATGACTGCACTTTTAAACCGTTTTTCTCTTCTGGTGGCTCTAAAAAAGCTCTATTAACATTACCTATTAAACGCGTTAGCTGAAACACTATTTCTTTTTGTACTCCCTGCGTAGTCGAATAAGAAGCACCATCTAAACTTTTAACTGCTTGGTCTATTTGATGCTGAACATCGCTAGAAGCGTCTAATCTATCGGTATCTATTAGCCTTTTGATTTCATCTTTTATTTGTTTAACTGAGTAGCCCGTGTTTTTAGCCCACTCATCCCAACCGTTAATATCATTAGATAAACCCATCAAATAGGAAGTCGGAACTTGAAAGAACATTGCTAGCTTATCCCAAGTTTCTATTTTTGGCTCTCGCTTTCCACGTTCATATTGGCTAATAGTTACATATGACATATTTACTTGTTCACTCATATCTCTTAATGACAAGCCCTTTGCTTGTCTTAATTTTTTAATTCTATTCATGCTTTCACTTCCATTCTTTCACTAATCTTAACATAATGTATTCGTTTTGAAAAAATATTTGCGTTTTCATTTTGAATACTTTATCATGTATTCATAAAGAATACAAAAAAGAAGGCGAAAATATGCAACTAACAGAAAACCAAGTAACAGCGATTAAGCGAAAACGTGGCGAACTTGACATGTCTATTACAGTTTTAGCCAATACTACCAAGGTTAGTAAACGTACTTTAATAGATATTTTCAAACACAACCACAGAAATGTGACTAAAAACACGTTTAAGAAGCTAAATGATTGGCTGATTGATGAATATGAAAGGAAGCAATAGCATGAAGCGAATTTATAGAGCATTCAAAGACTGGCTATATTTACCAGATAGCAATGAAGCCGAATTATACAACTTGCTACTTTTCGGCGTTCTATTCTTAAGTGCAATTGTAGCAATCGTAAGTTTTACCAGAACACTTGCAATGTTTTTGGCATTGATTAGATAAGAATGGAGTTTTAGAAATGATGAAGAAGATGAATATTGTTTATCTACCACTGGTAGAACAAGCTTATCAGATGATGAAAAAGCTTAATAAGAACGTATCTAAGCAAGAGATTTACAAGAAACTAATTGAAACTAATATGATTGACCAGCAAGGTAATCCTACCAAGTGGGCGCTTGATAATGGGCTAGTTAGTGAATTTAACACAATTGAGGAAGCAAGAAATAAGCTTAATCAAATAAGCCCACAAAAAATAGAAGACCAAGTGGACGCAGATATAAACAACGTATTTAGTCGCGTGCCAGTTAGTGCCTTTAGATGGAAGAATGAACACGATGGATATGCAATTGATAGTGCTGAACTTAAAAAGGCTATTCTATCAGCATTAAAAGATGGTAGCTTATCCCCTATCGGTCGTAAGCACTGGCTAGAAGTATTAGCAGATATAAATTCACAGGAGAATTAAGAACAATGAAATATATTGAAGTTAAAACCTTACCTATTAATGAAGATGAAGTAATCACATTAGCAATGAATGCAAACAATCTTACCGCTGGACTTGACTACCTTGAAAGCATGGCTTTAAACCTAGAGGGCAAAAACCAGCAAGAAATAGAACAACTATCAGGATTAATAGCAGGTATGAAAGAATTATCAGCAAAGAACGCTAGAATTTTAGCAAATATCAATCTTTAGGAGGTTACACAATGGATATTAAGCTAGACGCATCCCAAGAACAGGATTTAAGCAATCACATTATTAATTTAGTGAAAGACAGCGTAAAACAAGCAGTAAACAATGAAAGCAAGCCCTATTTAAATCGTAAAGAGATAGCTAAGTATTTTGGAGTTGCTGACAGTACAATAAGTTACTGGGCTACTTTAGGGATGCCTGTTGCAGTTATTGATGGACGCAAGTTATACGGTAAGCAAAGTATAACTAACTGGCTTAAGAGCAAAGAAAAAGCCGTGAAAAGCTGAGACAATTCACGACATAAAAAATAAAAACACAATTAAATATTAACACATATAAGTGTACTGGTTGGCTGATATTAAATATTTAATATTAAAAAAAGAAAAATGGAGGTTAAAAATGAACAGCAATTCAGACTGGGCTCTTAACTATGCTAAACAGGGCTTTTCTGTCGTCCCTACTAACCCAAGTAATGTAAAAATACCCGCGATAGAACACGCAGGAAAACCACCGCTAACTCAGGAAGAAATAAAACAGCTATGGACTGAAGAACCTAATTATGGCATTGCTCTAAAAATGACTAATATTTTTAGCATTGACGTAGATACTCCACAGCATGCAGGAACAACTAAAATAGACGGCTTTAAGTCGTTAAAAGAGTGCATCCCGTCAGAATGGTTACCAGATACGTTAAACGCATTTACCCCAAGCGGTGGGATGCACTTTTATTATATGAAAGTAAACGGCTTGCCTAATAAATCAGGTGCAGCAATCATCCCTGGCGTAGACGTTCAAGCATCCCCTAATAGTATCTCTGTAGTACCACCAACTAAGCGCCAAGATGGAATTTATGAATGGAATCTAGTACCTGGGTCTAAAAATCCCGTTGCTATTCCACCTAGAGAATTAATTGATTTTATTCAAGAGAAAACAAACCAAAACGCATCAAAGCCTATTCTTTTTAAAACATTCAAAGCTAAAAATTACGCAGGCAAGTTATTAGACGCTTTATGCTTTCAACAAGTCAAGGGACAACGTAATAGCTATTTAACTTCATTAATTGGCAAAATGCTATTCTGTGGTGCTGAAGAAGAAAACTGCTACACCCTTGCAATGTTTGCCAATAGTCAATTTCAAGAACCATTACCAGAAAAAGAAGTTACTTCCATTTTTAACAGCATATTAAGGAAGGAACTAGCTAATGAAAAATAAAAAAGTAAAAATGAATAAAGAAACAAAAGAGCTAATTAATTCTCACAAGAAACAAAAAGAAAAAGCGCCTAAATTGCCAGCTTGGTGTTATGTAGATGACAATGGCAATATAAAGGTCAATATTGGATCACTCGGCGAATTAATACAGAAAGAACGCAATTACTTATTCATTATTAATAAGGATAAGGAAACACTTTACGAATATAATTATAAGCTTGGTTATTGGTTACCTATCTCTAAAGGATCAATTTCAAAAGCTATTCATGATAAATTAACGTCGGTTGGTAAATGGACGTCACAAAATCAAAGAAAAACCTATGAATTTATAAATAGTGGTATTCCAAGAAAACAGTTCCAAGATACAATCGGACACTCGCCAGAAATGGCATTTAATTTTCTTAACGGCGTTTACAACTGGTCAACGGGCAAATTAGAACCCCATAATAAAAAATATTACTTTGAGGGATGCACCAGCTACCCACTAGACATGGCAAACAATCAAACTTCTGAAACTAATAAATATTTTAAGTTGCTTTTAGGCGAAAATGCTAAAACCATGATGGAATTTATTGGTTACTCATTTTACCCAAGTTATGAACCTATTCAATGCATCGTGATATTGAAGAATGAAGGTGGAGACGGTAAAACTTGGTTTACAAACCATGTTATAAATAAAATGCTTGGAATAAATAATGTTTCTAATATTAGTTTAAATCAATTAGCGGACGTAAAAAATAACAAATTCAAACCAGCGGAACTATTTCACAAATATGTAAATGTTTCCAGCGAATTGAGTGAAAGCGAAAGCTCATTATTACCTACTGACTCTTTAAAAAAGTTATCTGGTAATGACTATATAAATGTAGATAATAAAGGACAACGTGACACACGCTTTCAAAATTACGCAAAGTTATTAATTATAACTAACACCCTTGTTCATTTTAGAGATGATAGTGATGGCTTTAGTCGTCGTGTTTATATTATGCCAGCTCATAAAATACCAGACTTTGAAAACACTATAGATGTTAGGAAAATGGAGGCAGAACGTGGAGCATTTGCGTATAAGTGCATCGAATTAGCTAAAGACGCAATGAAGCGCAAGCCTGTTAAAGGGAAAAGATACCTTACTAAAACCAACAGTATTAGCCGACTAGTAAACAACTGGATGCTAGACAATGACCCAGTGCAACAGTTTATTAATGATTGCGTTACCAAAGCACAAGGTAAAAGAGAAAAAGCGCTAGATGTAATTCAAGCTTGGAAAAATTGGTGTAGTGATAACGATTATAAGCCGTTAGGCAAAACCAACTTTAAAAATAAAATGATTAAAAAGGGGTTTAATTATCATGAAGAGAGAAAACGCGGTTCAGATGGCAAGCAACTACCGAGAAAGTATTATTTTACTAATATGACGCTTAACGAAAATGCTAACCCAGAGGGAAAAATAAACCCAGTTACTAATAACTATGACTTTAATAAATAGAAAAAAACTGAAAAATTGGATTTATGCCACTTTTTAAAATCGGGTTGAGCCCTAGGGGCTGTAGTAATATGCCACTTATCCACTTTTTTTATTAATAAAAATTAAAAATATAAATATATATAATACACATAATATATATTTATTACGTAAAAATATATTACACAGAAACCCAATGGAAAGAAAAAAAGTGGCTTTTCAGCGCATCCCTTGTGGCTCTAAGCATGAATCCACTTTTAAAAACTGGATCAAACTGGAACATAACCACTTTTTGCAATTAATTTAAGGAATTTACAGAATGAAACAAGATAGATTAAAATACGAGCTTAAAAAATACCTAAATAGTAAACTGACCTACCCACTACACACTGTGGAAGATATTAGCATAGAAAGAATATTAAAGGTTTATGGCAGCGAAAAGCCTAGCGGTTATGTAATTCAACTAATAATAACTGGGCAAGTAGGTACAATACGAAAGGATAAATAGAATGGTAGACAAAAATCTTGAACATACCGTGTTCTTTCACAGCATGGACAGCTTGAACGAATGGCAAAGAAAATACTACAAAAAGATAATTATTACTGAACGCATGGAGACAGCTAATAACGATTACTTAATTACTTTCTTTTTAAATCGGAAACATTTAAGCGTAAAGCCTAGCTATACCGACCAGCTTATGAATATTGCACTGGATGCGCAAACTATAGACTACTATCACAACGGAGTTAACATAGTAGATTTACTTTAACGCTGGTATTATAATATAGACATACATCCATATAAGAAGAGATCAGTAGCTTAATTGTCTGGCTGCTGGTCTTTTTTTGTTCGCTCTCATCCCTACCAGATGGCTTATATTAGCTTGCTGGCTAGGCTAATTGCGGTTCTCTTATGATTTATCATTTACACCTGTGGAGGTCTCACGCTGGCTTATATGCTTGTCTGCTTGGTCTTCTGGCTGTCCTGTCTTTTCGTTTTTGCTTTCTCTTTCACTGGTTTCATGCCTTGAGTTTCAGCAAGCTCAGCTAAAGAATTTAAATTAGCAACTAATTAATTAAGAAAGCTAGCCGTCCATACAATGGCTCTCTCAGCATATCGAGGGATGCGTACGAGCGTAGTTACAACTACAGACATGCTAGCACTAATAGATTATTCATACCTGTCTGCTTTATGGTCACTCAATGTAACCGCCGAAATAACTCGTTATCAATCTAATTGATTTAGAAAATTAAACCGCAATCAAAAATAAGCAATGAATGAATTTAATTTCACTCACTGTTTTTTTATTTTGCACCCCGCCCTACCTTTCAACGTTGCAGAGCCACACATTGCTGTCGCCTCGTGTGAAACATCAGTTGTTTCACAATTAATTGAGGGGGGTTATTTATAAACCTTATTACTACAGTATTTATATATGTATTCCTGCTATTTCTAGACGGAAAAAAAAGGCTATTCAAACCTTTCTGGAATGAATAACCTTGACTGAATTGATTCTTACTAGTTTTTATTATGCCGCTTCTTTATATTCGTGCAAGTCTAGAACATCTTTTACACCCTGTTTTAACTGTTCCATCAGATAAACATCGGCAAACTGCAAGAGCGCCCTTTTACGCAATACATTATATTGAGTGTGACCATATCCAAGGCAATTAGCAATGTCCCAGCTAGCTAAATGCTTAATATATCTAAGCTCTAGAATGCTCCTGTATGGCTTAGTTGGTTCATTGGTGCAATTGCCTATGGCTGGCTTTAAACACGCTAGACGGTCGTTATATGCAATTATTAAGTTATATCTGCTCGCCACTGCATCGGGATTAATTGAACTATTTACCTTGATATTATCAAAATTCAAGCCGTGGACGTTGTACCGACCAGCGCACATTGTCTCATACCATTCTAAATCCTTAGCAAAAAATTTCTCCACGTTTTTAACTGTTTCTGGTTCATTGATTTCTAGCATACCTAGCAACTCCTATATTTATATATTATTGGAATATCTAACATAATTATATTTTACTATGTTTTACCAGCTGGCTTATTAACTGCAAAATAAAAGAGCTACCTTAAAAAGGCAACTCAAGCCGACTAATTAAATATCTAAAATCAACCAATCAATACGCTATTACACTTTTAAGAATATGAAGCCTAATATGAAGCCCGAAAATACTATTTTTTATTAATTTGATTTAATCATAGAAAACAAAAAGCCTTTAATATCAACGTTTCTAATCCATTGACATTAAAGACTTTTAAATTTATGGAGATGAGGGGAATTGAACCCCTGTCCAAACGTATTCCGTCGTTAACCTCTACGATCATAGTTATATTACTTAAACTTCGCTTTGATAAAACGCCATATAACAGGGCTAAACTATCAAAACTAACCTAAGAATCTTATTTCTAACTATTAAGGTAAGTAGTTAAACGTAGCTCGTTAAATGGTAAGACCCGCAGACAGACACGAGCAATCCGTCATTGGATCACGCAGCCTGACTAAGCAGCTACTGCGTAAGAATTTTCGTTATTTGCAGTTATAATTTAACTGTGACGTTTTAACGTAGACGTGACCTACGAATCGCAGTCAACGCGAATCTACGCCTGTCGAATCCCAAAACATCCCCAGATGTTTCAATGATATCACAGTCACTGTTAAAATGCTATAACTTTGCTTTCACAGCTATTTATCTAATTTAGCTAAACGAACAACGTCACGTGCAATCATTAACTCTTCATTTGTTGGAACGATCATCGCAGTAATCTTTGATTTCGGTGTAGTGATAATTCCTTCCTTGTTAGCTTTATTAGCTTTTTCGTCATATTCAAGACCAAGCCAAGTAAGACCATCCATAATCTGTTTTCTTACACTTGCATCATGTTCACCGATTCCTGCAGTAAAGACTAAAACATCTAAGCCACCCATTTCAGTCATATAAGCCCCAATATAGCGAACAATTCGGTTAATAAAAATGTCTTTTGTAAGTTTAGCCTGTTTATCACCATTTTTAATTGCTTTTTCAATGTCTCTCATATCTGGGGAGATTCCTGAAAGACCGAGTAAACCAGATTTAGTGTTTAACATCTTAATAATTTCATTAAAGCTGGTAATGTTGCCTTTTTTCATAATAAATTGAAGCAAGGAAGGATCTACATCCCCACTTCTAGTACTCATTGTAATTCCTGCAACCGGACTGAATCCCATTGAAGTATCAAAAGACTTTCCATCTTTAATAGCAGTAACTGATGCACCACTACCTAGATGACAAAGAACCATCTTCAAATCTTCAACTGGCTTCTTTAATAAGTCAGCTGTCCGACGTGATACATAGCGAGCAGAAGTACCATGTGCACCATATTTTCTAGCACGGAACTTTTCATAATACTTATATGGTACTGAATATAAGTATTGAACAGGATCTAATGATTGGTGAAAAGAAGTATCAAAAACAGCAACCTCAGGAACGTTAGGTAAAACTTTCATAAAAGCATAGATACCGTCGGCTTCAGCTGGGTTATGCAATGGTGCATAGTCACTCATATTATAAATCTTCCAAAGATTATCATCTGTAATGACTGTACTATCAGTAAATTCTTCACCACCAGCAACAACACGATGTCCTACCCCAGCAATATCTGCTAAAGAATCGATCACATTGTATTCTTTAAGCCAGCTAAGCAACTTTGGGACTGCTTCTTCTTGATTAGCAATATCACTTTGTTCATCATGTTGACTGCCATCTGCTAAAGTCATTGTGAAAACAGATCCTGGCAAACCAACACGGTCAGCCATACCAGATGCAATTACTTTTTCATTATCTAGAGAAAATAATTTGTATTTAAATGATGAACTACCTGAGTTTACTGCTAAAACTTTTTTCATTTTATATACCTCTCGTATTATATAAATTAATCTTCACTCTTATGATACCAGTCATTTAGTTTCATATTAAATGCTACTAAAGATTCTGGTTTCTTTAATGAATCTAATTTAGCCACCAGAACCTCACGCTTAACAGCATGTTCTCCATGATTTTGAAAAACTAAAATAGATTTTTGTTGAATCTGACTTGAAAACATATCATCGGGCAAATCGACAATTGCCTGAATATTAACTTTTTTAGCTAACCAAGTCATGAATTCAGTAGATCCTTTACCAGTAAACAGTAATCTAGGTACTACTAAAAATGCAAAACCATCACGTTTAAGGTTATTTACTATTTGTTCAATAAATAAAGTATGAGCAAAAGAATGTCCCTCTTTTGCGTGATTTTCGAAGCGCTCAGCATTATTATCCAATGGATAATAACCTACTGGCACATCACTTACCACTATATCCGCCTTTTCAATCATCCATGGATCTAAAGCATCTTGACAGTATAAATCAATTTTTAAATCTTCAAGATGAGCACCAATATCTGCTAAATCCAATAATGCTTCTTCATTATCAATTCCAATTAATTTGTAATTGTTTTGTGAATGATTTTCCTGAATCAACTGTCTAATAACCGAATAAAGTAAATTTCCAGTTCCAATTGCGGGGTCAACCACAGTTTTTTTACCTTTAGAAACGATTCTTTGCCAAATTAAAGCAATTATTGTAGCAATCACTGAAGGTGTTGGCATCAAGTTATAGTCACTGGCATCTTGAGTAACTGCTTTTAAAGTTAATAGAGTAAATATTTGTACTTTTAGAGCACGTGGCAAATTATCATAATCTAATTGACGATACTCTTCAGTTAATTCAGCTACAGTTTCTTTATCTGGGGCACCCGATTCGACTTTGATCTTACCATTTTCTAGATTATCAAAGGTTTCCGTTAATGCCGATGAAAAAGAGACATTCAGAGCTTTTTGTAAATGCTCAATAGCCTTCTGAAACTTTGGATATAATTCTTCTACTTTTTGCATTTTTCTTCCTTCTTTAATATTCCTTCTAATATTTTATAGGTATCATCAAATACTAGCAAGCAAACAATGTTACTTGGAAAAATAATTTATTAAAGAAAGATTACTTTCCATATTTTCAGTAAAACTATGTTGATACATCATTACGAAAGCAATACAAATATTAATAAGCAGTAAACTACTAATTAAGGCACTTCCCTTAAGTCTTTTTACTATTATCTTTTTTCTCATCCTTTATTTTATCTTCCTTCTTCTCTGGTAAATCTGTTTTGAAAAACATCTCACTTTGCCTACCATCTTTTTCAGTTACTAAAATAGTAAAAGAATCTTTTGCAGTAGAACATTTTATTCTTTTAACTTGAAAAAGCAGTGGCATGTGCCCTCCCTCATCTGTTCTCATTCTCAAAACATCATTTGAACTCATATCAATTACATATGTATCGTAAATTAAATCACCATTCTTTTTCTTCTTATCCGATAACTTTCTAAGAACAATTTTAGTTGGATCTGAACCAGTTGTACTTACTTCAACATGTCCACTTTCTTTTAAGAAATTATTTATTTGTACATAACTATACGTAATCTCATTAACTCCGGTTTTTTGGCGATTAATTTTTCTAAGTGTACCTACAAGTCCAAATAATATTTGTGCACATAAAATAGTAACTGCGATTGCAAACACAGCTTCTAATAAGGTAAAGCCCTTTATCTTTTTCATTATTCTTACCTACGATAGAGATGATCATGCACTAATAACGTTTTTTTATCACTATGTCTAAAAATATATTCCGCATATGCCTTATCTACTCGTTTTTCAATTTGTTTCTCAGTCTGCCTATTTTGTTTAATTGTCATCCCTAAAAGCAATACTCCTAGACAAGCTATCGTAAAGCCTACACATGCTTCCCACAAAATGAAGCCCTTTATTTTTCTATTCTTCAACCATCCTACCCCATGTCATCTGTATTTTTATCTTTTTCTCTTTACTTCCACTCTTAACAGTAATTGTTCTTGGCGATATCGTTCCGCGATTGCTAATGTATAAATTATTAAAATTATAAACTCTAACATGTCGATTCAAATATACTTTTGATACTTGATGTGGCTCCATTATCTGAATTGAAGAATTATTGTCAAAATATGATAAAAAATATGACTTCTTTTCTACTGTTGAACGGTGTAAATACTTATTTATAGTTGATCTAATTTGACGCGTAGTACTATCCAAAATTATTTGTTCCTTAATATTTTTCACGTAAAGCGTTGGCATTAACACAAGTAAACAAACTATTGCTAAAGTAACTATCGTTTCAACTAAAGTAAAAGCCTTTATTCTCTTAAAAATCATTTTTGTGGTAATTTTTCATATCTCTCTTTTTGTTTTTGAGAAATATATTCTTTCTTTACCAGCTCTTCTAATGAAGTACCATCTCCATTATCTGCAGCTAATTGTCTTTGAGTCTCAACCGTTGTTCTTAAGGCTTCATCTGTTTTACTAGTTGCTCTCTCTTTTTGCTTACTTAGTCCTGGAACAATTAGCAAAATCAACATCGCAATAATGGCAATTACAATTACCATTTCAACTAAGGTAAATCCTTTTACCCGTTTATTTTTCATAATAAATTGTTTTAACTTTTTCATTTTTCCCTCTACATTGTTTCCATTAAATGATACATTGGCATTAAAATTTTCAAATACATCCCCAGAATACAAATTCCAATAAAAATAAAGCATAGTGGCTGCAAATTAACGATTAAACCATTTAATTTGAGATTTAGTTCATAAAAAAGTGTCTTGCTAAGTAATAGCGCTCTTTTCCCAATTTGCTCTCTTGTTGTTCCGGTTTCTAAAAGCATAACTAAGTTATTAGAAATAAAGGCTTCATTCTCAATAATTGTTTTAATCTCAGTTCCTTTTTCTAACTGATTCTTCACTTTTGTTCCTAAGACTTGCTGTAATGAGTTCTTTGGTTGCTGATCAGTAAGTTGGCAAATTTTTTGTAATGAAAAGCCGTTGATTAATAAAACAGCTAAGTCAGACACGATAAGATAGTGAACATATAAATTTAATGTTGGTCCAATTACAGGTATCCTAGTTAATTTCTTCAGTGCATAATAATCTTGCCTATTAAGTAGCCTGATTACCTTACTAATAAAAAATGCACCTATAATAACTAACATCACAAGTCCACCCAGCATTACATTACTCGTCCAGTCATTATCTGACATTTCTGTCTTTAAAAAAGTTTGCATACAAATTAATAGCGTAACCATCATTCCAATTAAAAGTGCTGGATAAGCTAATTCTCCTCGCAGCTTCTTTAACTGCTTATTTTTCAAGCGAATAAGTTTACTTAATTGGTCCAAACAAGACAATAAATTGCCATCAATAATTGCCATATTTATTTGTGCAGCTAAAGTACTAGAAAATCCTACTTCATGCAATACATCCCCAAGTTGCCTACCTTCTTCAACCTGTTTACTTATATAAACTAATTGATTAGAATCACCACTCCATATTTTAGGCAGCAATTTTAAACTAGCATTAAGCGAATAACCGTTAATCAGTGCTTGTCTTAAATAATCAATAAAAATTAATTGAGCAGCGCTATTTAGCTTATCCTTCTTCATAAAGATGCTTCGTATCTTCACTAATCTTTCCTCTTTCAACCAACTGCTCTAAAGCACTTTGCCAGTTGCGCAAATCATGACGCTTATCATTAGACATAATAGCTTGATCAAGTATTTTTCCATATCCAATATCCATTAAACAGGCAACTTTATTTCGATCTTTTATCGGTAACAATCTTTGATAAGAAGCAGCCGTCAAGCAATTGCACAATTCGTCTTTAGTGATTCCTAATCCTTCAAGCCGTGAAATTGTTTGTAAAGCTGTTTTTGCATGAATAGTTGCTAAAACCAAATGTCCACTTAGAGCTGCGTTAATACTGATTTTGGCAGTTTCTTGGTCTCGAATTTCTCCAATAATTAAAATATCCGGTCTATGACGTAAAGCAGCCTTTAGTAAATCTGGGTAAGTAATTCCCGCAACAAGATTCACTTGTGTTTGTAAAAAACTTGGATTCCAAACCTCGACTGGATCTTCAATAGTCATTACAACCTTTTTTTCTCCAACTAATTGCGCTAACTCATACATGGTTGAGGTCTTTCCTGATCCTGTCGGACCGCTAGTCACTATCAGCCCACGTTGATTGGTGAGTCTTTTTAGCAAATCAAATTGTTCGGGGAGAAAATAATTATTACTTTTCCCTTCATAAATTAATCGAACTACTAAAGACTCATCTCCTTCAAATTCCCCTACACTTGAGAAGCGTAAAAAGACCTTTTCACCCCGAAATTCAGTCTGATACGCCCCCACTTGTGGTCTACGACGCTCAGATATATCCATTTGCGCCTGAAACTTGAAATAATTAAGTAATTCCTTTCCTACTTTCTGGCTTAATTCTTTTATTTTACTCAAACCTAGGGCAGTTCGAATCTTTATTTCATATCCTCTAATAGCGGGAAAAATAAAGATATCACTAGCATGGCTTTCAATTGCTTTTTCTAAAATAGCTTCTGATACTTCGTTCATAATTAATCCCTCCTTTGCCATACACTTATTAGTACGCGAAAATAGGCCATATTTTTTATCATTTTAAAAATTAAGAAAAAAAAGACTGACACAAAGGTCAGCCATAAAAAATAGACCTAACAAAATTAGGTCTACTTCTTGATAAATTATTATTCATCATCATCTGCAGCAGCAGTATAAACATTAGAAACATCATCGTTATCTTCTAATGCATCAATTAAATGAGTAAATTGCTCTTTTTTATCTGCTGGAACTGGAGTGGTGTTTTGCGGAATCATAGTTAATTCAGCGTTAGCTAACTTGTAGCCAGCTTTTTCTAAAGCATCACGTACAGCAGTAAATTGCTTAGGATCAGTGTAGATTTCGAATGCATCATCACTAGTTTCTAAATCATCCCCACCAGCATCCATAACATCAAGTAAAACTTGGTCTTCATCAGCATCAGTAGTGGAACGATCAATTACGATGTAACCCTTACGGTCAAACATGTAAGCAACGGAACCAGTTGCACCGAGTGAACCACCATTACGAGTAAAGGCAACACGGACATCAGAAGCAGTACGGTTCTTGTTATCAGTTAAAGCTTCAACTAAAACTGCAACACCACCTGGTGCATAGCCTTCATAGGTAATTTCATCATAATGTTCATCTGAATTACCTTCAGCCTTCTTAATAGCACGTTCAATGTTAGTCTTAGGCATGTTTGCTGCACGTGCTTTATCCATAACCATACGTAAAGTAGGATTTCCTGAAGGGTCAGGACCACCACTCTTTGCAGCCATATAAATTTCACGAGATAATTTTTGGAAAACTTTACCTCTCTTAGCGTCTTGCGCATTCTTGCGGCCTTGAATATTGTGCCATTTTGAATGTCCTGACATAAGAATCCTTCTTTCTTTTTATTTAATATAGTTAACCTTGTCAATCATAACGCACTCAAGGTTTAAATTCAATCTATGATTAATTAGGAATTGCTTTTTTCTTGATGGTGTCTAATCCAGTAAACAAAAATACAGAGTAAAATAGCTAAAAGCGCTCCAGCTGAATCAAGAGCAACATCGTGAAGACTTGGGGTTCTATCTCCTGTCAAATATTGATGAAATTCATCTAATCCAGCTAATCCAATAATTCCTAACCAGATAAACAAAGGTCCACACCATTTTTTAAATAAACGATCTAATCCTAAACAAGCAAATAAACCAACTAAAAAATACGATGAAAAATGGGCAAATTTTCTCATGACAAATTGTGTCATTCCAGCTTCCCCATTGTCTAAAAATGCATTATGCCAGCGACCAGCATAATAAATATTCCATTTTCCAACTATTCTTTCAATAATCGGAAAATGTCGATGAATAAATCCTGGTGACATCTCTTGTTCGTGATAAGTCATCGAACTGGAAATAAATAAACCTAAAAGCACTAAGAGCATCAAACAGACAAAGATCATTTCTCGCTTAGTTAATACTGTTTTTTTCATTTTTCAACTTTCCTACTTTCAAGTTCTTCAGCAACCAAAACAATTATTTTTTTAGCAATTTCAACTTTAGTTGTTTCTGTAATATTTTCAGTTGTTTTATCTTGCCTTAAAACCATGACTTTATCTTCATCACTACCAAATACTCCATGACTGACATCATTTGCAACAATCATGTCAGCTTTTTTCTCTTGCAATTTTTTCGAAGCATTTTCTAATAAGTTATTTGTTTCAGCAGCAAAACCAACAACAACTTGATTCGCTTTTTTTATACTTCCCATTTTTTTCAAAATATCAGGAGTTTCTTTCAAATAAATTTTTAACTCATCCCCCTGATCCTGCTTTTTGATTTTATGAGCAATATAATTTACCGGTTCATAATCTGCTACAGCTGCTGCCATAATTAAAGCATCTGCACCTAAAAAAGCTGTCTTAACTGCTGAGAGCATCTGTTCTGTAGTTTCTACCTTAATGTTTTTTAAACTAGGCGAATTAGGTAATGAGACAGCAATATGACCCGAAATTAAAATCACCTCGGCTCCAGCAACAAGAGCAGCTTTAGCTAAAGCTATTCCCATCTTACCACTTGAACGGTTACCTAAAAAACGAACCGGATCAAGCGGAGATATTGTTCCACCTGCAGTAATTACAATTTTTTTACCAGCTAATATTTGTTTAGCTTGAAAAGAATCATCTATCCAAGCCATAATGTTATCTGGCTCTGGCATCCTTCCCTTACCACTATATCCTTCAGCTAAGCGCCCAGTAGCAGAATCCATTACCGCAATTCCATCTTGTTTTAATAAGGCTAGATTTCTTTGAAAGGCTGGATTACTCCACATATGACTATTCATAGCTGGAACTACATATTTAGGTGAAGCTGTTGCTAGGAAAGTTGTACTTGCCGCATCATCAGCAATACCATTTGCAATTTTAGCAATAAAATTAGCCGTTGCTGGAACTACAACAGCAATTTCTGTCCAATCGGCTAATTCAATGTGCTGAATCTGATCAGCTCTTTCTTTTTCCCAGAGATCAGTCAACACTGGATACTTAGTTAAAGCAGCTAATGTTTGCGTACCGATTAAATGGACAGCTTCTTTTGTCATAACTACTCTTACTTCATGTCCCTCTTTTTGAAAATTTCGTACAACGTTAATTGCTTTATAGGCGGCAATACTACCTGTAATATAAACTGTAGCTTTCATTTTTCTCAACCTTAATTTCATAATTTCTTTCTACTATAACACAAGCTAACTAAGACAAATTATTAAAAAATAAATTATCAAATTAAAAATCATTAACGGATTCTGATATGATTTATATTGAATAAAGATATCGATCACATACCTTGAAAGGATAAATATACAAAATGAAAAAATATTATCAAAAGATTTTTTCTCTCTTTATTGTAATGGGGGCTTTATTTCTAGTTCTTACTGGCTGCTCCAAAAAAGAAAATTCATCGTCTAACAAAATCTCGATTGTTACCAGCACCAATGTTTATGCTAATATTGCACAAAATGTTTTAGGTAAGTACGGCAAAGCAACAGCCATTATTACTAGTAGTTCCACCGATCCCCACGATTTTGAACCAACTACTGCAGATGCAAAAAAAGTTCAAGATGCCAAAATTGTTGTAGCTAATGGTTTAGGATATGATTCCTGGCTAGCAAAACTGGCTAAATCAAGTAATAAGTCTGCTGTTTTAGTTGGTGAAGACTTAATGAATTTGAAAAGCGGTGATAATCCTCATATCTGGTTTGACTTAAATATGCCAACAAAATATGTCAACTATTTGGTAAAGCGCTTATCTAAAATTGATAAAAAACACGCAAACTATTATAAAGAGAATGGAATTAAATATTTAGCAAAAATCAAAAAAGTCAAAAAAATAGCTGATTCAATTGATGGTACAAAACAAAAACCAGTATATGTTAGTGAACCAGTATTCGACTATGCTTTGAAAGCCACCCACTTTAAGATTGGCGATAAAGATTTTGAAGAGGCAATCGAAAATGAAACTGATCCGAGTGCCAAAATTGTTCATCAAATGAATCAAACTATTAATAATCGTGGTATCTCTTTCTTTGTTAAAAACTCCCAAGTAAGTAGTTCTACCGTTAACAATTTCGTTAAAAGAGCCAAATCAAAGAAGATTCCAATCTTGCAAGTTCGTGAAACTATTCCAAACAATACAACTTATTTGAAATGGATGACAGAAAATTATCAAAATTTAGCAAATATCGCTAAAAAGTTAAAATAATTACCAAAAAAGAGGCATGAGCCTCTTTTTTATTACCCTAAAATATCCTTTAATTTGTTATTAAATTGCTTAGGAATTTCTGCCATAATTACGTGACCAGTTGGTGACATAATAAAACTATCTACTTGATCATTTTTTTCTTCAAGCAACTTTTCATATCCTTCACGATAATACGGACTCTCCTTAGCAATAAAAAAAGTAATCGGAATTGTTGCGTTTTCTATAACTTTTCGCCAATCTAAGGACATATGATTTTCTAACAAGTCCACATTATCTTTTCTATTAAAGGGGTTTTCTTCTTTTGCTTTCATAAGTTTGGCATAAACACCATCATCTAGTCCTGCGAAAGTTTCATGAACATGGGGTCTTTCCTGACATTTTTTATGATAATTTTCACTTGTATAGTCCATAAAGCCATACTTCCAATTCTTATCATTAAGCATCTTAGGTGATTGATCTACCACTAATGCACGCTTAACAACAGTTGGCCATCTTTTTATTAGACAGAAAATAATCGAAGCGCCCATTGAATGTCCCATGAAAATAGCCTGTTTAATTTTCAGAAAAGAAATTAATTCTTCTAAATCTTGTGTTAAACGAACAATATTATGTCCTCTTTCTGTGCGTTGGCTCTTCCCCATATTTCGGTGGTCATAAGTAAGTACTTGATACCCTAAATTATTAAGAAATGGTACTTGAGCAGACCATATTTCTTGATATGCACCAAAACCATTTACTAGGACAATCGTCTTCCCTTTCCCAGTTAATTCATAATTAATTTTTACATTATCACTTGTTTCAAACAGCATTTTTACTCCTTATTCTGTTTAATTCTAATGAATAAACATCCAACTGCAGCAATAATCGCAATAATCAAAGCTTGACTTAATCCACTACTTAAGCTTACGTTGATCCCGTCATAAACGCTTTGCTGGAGCGAGCTTGTGGCAATTCCAGCCGCGTATGATAAAACACCATATGAACCAATTGCAGCAATCATAAGCGGTAAAATTGCAATCTTTTTACCAAATAAAACCATTACCATTGCCAAAATGTAGAGACCAATTAGTAGGAAATAAATCAAATGATAAATCTCAGCTGCTTGTTTTACATCCGCAGAATTCTGTCTTAATTGTTCATTTACTAATTGCAATATTAACTGATTAAAAACTTGTTCTTGTTGCGTATCATTATTTAGTTTTAGATCAGATGCAGCTAATTTACCATTGGCTAAATAATTAGTACTCAATTGATTTAGCCCTTGATATGATGTTTTTAATTCAATATTCTTGGGTAATTGTGATAAAAGCGTATCTTCGATTCCCGATTCTTGCAAAAAACTGACTCCCATTTGCAAATCACTATTATTCGCTTGGTCAACTACCTTATTAATTGAGCTTTTCACAAGACCAGCAGTACTATCAACTTTCAATTCAACTGGACTTGTTAAAGTCAAACTTAGTGAGATAAAGATTAATCCAATTACAACTAATCTCCAAATCCATTTTATTAATTTCATTTTTTCTCCTAACGAAAATTTTAATAGTCTTTTATAATCGCTAAAATACTACATAAAGTTTTTTTTAGTGCTATATAATAAAAGTGTAACAAATATTAAAGGAGTTCAGCATGATTGATGAAAAACTAAAAGAATTTTTCAATAAATTTCCTCATATTAAGGAAAATAAGCCTTTACAAAATACTCTGAGCAAGAAAATCAACAACCTAATAAAAAAAGAAATCCAACATGGTGCAAGTCAAGTTGAAGCGGAACAGAAAGCACTTTTAAATTTAACAGATCTAGACACTCTATTATCACAACTAAAAAATTTAGAAGAAACTGACTACAGTAAATATAATGATTTCTTTGCTAAAATCTTTGATTCAAAATTAGTTAATGAATTAAAACTTAAATTAAATCAAATTGATGAAATTCACCTTAATTACCGCTTGGGTGATATTTTAGTATTACCCACTAATTCATCAAACTTAATTGTGCATGATTTTATGTCTAGAGATATTGAAAATCTTCATTCAACGGTCGAAAAAATTGGTAACGTCTTAAAAATTACTCAAGGTCCACGTAAGCTGGTAGGAATTTTCAAAAATAAAACTTTATTATTTTTACCTAAAAATTTTACTGGCTTCCTAACAATCAGAAGTCAAAGTGGTGATATCTATATTAATAAAGTTCCAAATTATTGTATGCTGGATGTTACTGCAGTTTCTGGCAATTTATTATTGGCTCATTCTAAACTTAAACGTGTTCAAGCAGACTTAAAGTCAGGCGACATTGCTGTTTCTAATACATCTGCAAATGTATTTCACATTAATGCTCATTCTGGAATTCTAACTAGCGATCATGTTTGTGCAAAAGAAGAGATTTCTTATCATACAAGTAGTGGAAATATAGACTTAGAAAGTATTTCTACTAAAAACTTTTTTATCGATACTAAGAGTGGAAAAATTACTATTAATGACCTTAATAGCGAAAGAATGGATTTAGTTACTGATACAGGAAATATGAGCTTAAATAAGGTTAACGGTAGCGGTGATATTAAGTCTGGAATTGGGAAAATATCCTTATCAATTGCTGATAAATCTAATTTTAATTTTTCAATCACAAGTAAAGTTGGAAGTATCCGCGTAAATGTACCAAAGAAAGAATTATTTAAATTCAAAATCAATACTAAAAAAATCGGCCCTACTGATCTTCCACTTGACTCCATTATTTATGGTAATAATGAATATGATGAAATTGAAGGATATGTTGGTAATGAAAATTCAAGTAACTCACTAACGATCACAAGTGAAATTGGAAAAGTATCAATTAAGAACGAAAATTAAACAACTTCAAGCGAAAATGCTAGCAAACCTAAAATTTGCTAGCATTTTTTCTAAATTATTAAGCCTGCTTTATATCCTGCAAAAACTAAAATTAAGCCGCCACCATAGGATAATAAAGCATAAAGAAGGAATGTTTTGTAATTATGATCCTGCCAATGAGAAAGCAACTCAACATTTAATGTGGAAAAGGTCGTATAACCTCCCAGTACCCCGGTTCCAACTAAAGCATAAACAAATGGCGAAAAATTGCGCGAAAAAACTAGCCCTAACAAAAATGCCCCAGTAAGATTTATTAATAAAGTAGCATAAGGAAAGTTGCTAGACCAATGTTTTTTACCATAATTAGTAATTCCGTACCTAAGAATTGCTCCCCAAATTGCTCCAAAACCAGCTGTTACAAGTGTCGTTATCATGCTCTTATTGCCAACTTTCTACCCAATATTTTTCCTGTAATCATTCCTAAATAAGCAAATAAAAATCCAATAAAGATTGAACTAAAGAAATATATCAGCGCCTGATTATTCATTCCGCTTTCTAATTGCTTGAATGTATCCAAATGGAAACTAGAAAAGGTTGTAAATGCTCCTACAAAACCTGTACTTAATCCTGTAACTAGCCAATCTCGTCCTTCCCTAAATTCAATAAAGAAATATGTTAGAAAGGCTAATAAAAAGCAACCAATAATATTAGCTACAAAAGTTCCAGCCTGTGACCAAATCACATTTAAATAAGCACGTAATGCTCCTCCACAAAATGCAAATAAACCAACACTGATATAATTTTTCAACTTTTTATTCATTAAAAATCAACCTTCTTATTGCATACGCAATTCCATCTTCATTATTTGTTCGAGTAACATAATTAGCTCGCTTCTTTATCTCTAATACCGCGTTTCCCATAGCTACTTTATAAAAATCTGGAACGTCAAACATGGAAATATCATTCTTTTGATCACCAAAAATCATTATTTCATCTTGTCTAAGATTAAGTTTCTGCGCCAATTCTTTTAAAGCGTTTCCTTTTGAAGCTTGCTTAGAATTAATTTCGATTAATGTTTTATCAGAGGTAGAAACGTTATATTTTTCAATAACTTCTTTGGGCAGGTGCCGATAAACTCTTTCCATTTCTGATGGAGCACCTGAAAACATGGCTTTTGTAAATTTTAAATCTTTAGCTATATCTTTAAATCCACAAACCTCAATCGACATTCTAGTCAGCCAGCTTTCACGCGATAAATAATAATTAATAAAGTGATCTAATGTAATAAATTTATCACTCACTTCAATATGAAAGTTAGCCTTCAATTGTTGAGCTATTTTTTCAAAAAAAAGGAAATCTTGATAACTTAATAATTCTTCAACTACTGCATTTCCTTGTGCATTCAAAACTAGAGCACCATTAAAAGCCACAACATATTGATTAGGATCTTGCAGATCTAACTGATCTAAATACTCTTTAATTCCTGGAAATGGTCGCCCCGAACAAGGAACAATTTTAATTCCTAATCGAGATGCTTTTTGTAAAGCTTCCCTTGTTTTAACACTTATTTCTTGTTTATCATTCAATAAAGTTCCATCAAGGTCAACGGCAATTAATTTTGTCTTCATCAATTTTCTCCTATGTAATCGTTCACTTTCCTTTCTATTATACAAAAAAAGACGACACTACTCCCTTATTACACATAAGAAAGTAGGCGTCGTCAGATCTTAATCGGTTAAATTGGTGAACGCCATCACCTATTATAATTTAATAAAAACAGTTTACTTTGAGCACATCTCTTCTTCAACGACCTTAGCAACTTCTTCACAATACCCATCAGCTAATTCTTGTGTTGGTGCTTCAGTCATAACACGGAGTAAGCTTTGAGTTCCAGATGGACGAACAAAAATCCGTCCTTCATCGCTCAACTCTTCCTCTACCTTTTTAATAGCTTCGGTAATTCGCTTATGTTCTTTCCAGTCTTTCTTATCTTTGACAGGAACATTGATTAAGCGTTGTGGATATTCTTTAAAGTCGCTTAATAATTCACTTAATGACTTACCAGTATCCTTCATTACGTATAATAAATGCAATCCGGTAAGCATTCCATCACCAGTATTATGATAGTCACTGATAATAACGTGACCAGATTGTTCACCGCCTAGATTATAACCATTAGCTCTCATTTCTTCTGAAACATAACGGTCACCAACTTGAGTTCTGACATTCTTAAGGCCGCGTCTTTCTAAAGCCTTAGTAAAGCCTAAGTTACTCATTACAGTTGTAACAATCGTATCTTTCTTTAAACGGCCATGATCGGCAAGATAGGAACCAATTACATACATAATATGGTCGCCATCAACTTCATTACCGTTTTCATCAACAGCGATACAACGATCAGCATCCCCATCGAATGCTAAGCCCAGTTGAGCACCTTGCTTTACAACTTCTTCTTGTAACTTTTTAGTATGAGTTGCACCTACATGATCATTAATATTTAAGCCATTGGGATGAGTTGCGATTGTAGTAAAATCAACGCCCATATCAGCAAATAATCTTGAAATCAAAGCACTAGCTGCACCATTTGCACCATCTACAACAACTTTAATTCCACCTAATTCTTCAGGTAAAGTATTTTCAATAAATTGCAAGTACTTTGAAGCACCTTCGTGGTAATTAGTTACAGTACCTAAGCCTTCAGCTGAAGGACGTGGAAGCTTATCTTCTGGTGCATCAATTAATTTTTCAATTTCTTCTTCTTTAGCATCAGATAGTTTCAAACCATCACTACCAAAGAACTTAATTCCATTATCTTCAACTGGATTATGAGATGCTGAAATTTGAACCCCAGCATCTGCACCTTGAGCACGAACTAAGTAAGAAAGGCCCGGTGTTGTAATCACACCAACTTCTAAAACTTCAATTCCGACGGAAAGTAAACCAGAAATCAATGCATACTCTAACATTTGTCCAGAAATACGAGTATCGCGTGAAACTAATACTTTCGCTCTTTCTCCATCTTTTTTATCTTTTGTAAGAACATATCCTCCATCACGACCTAATTTAAAAGCCATTTCTGGAGTTAAGCCAGCATTAGCAACCCCCCGTACACCATCTGTTCCAAAATATTTAAGCATAATTTAACAACCTTTCCTTGTTTTATTCTTTTTTAGCAGTAGTATCAGTTACCTTAATATGAACTGGTATTACTGATGGTGAAGCCTTAACTACGCCCTTCGGCAATTTAATTGTTACATCTTTTGTAACATCTCGATTGATACCACTTAAATCAACTTTTAAGGGAAGAGATGTTATCTTCTTTAGCGTATTCTCATCACCATATATCTCAACTGTCTCTACTTTTGCGGTTAATGAGTAAACATGAGTTGATGATTCATTTTTGGACGTCACGTTTATTTTAACCTTCTTTTTCGACAAGTTAATTGGGATAGTAATGTGCGCTGTTGCTGGATCAATAGCAACATTGAGTTGATGTCCCTCTTTATCAAGTGCTACCAGCATTTCTTCACGCTCAAATGTGCTGTCTATTCCCTTTGGTAAATTTGCGTGAGCTACAACACGATCAACTTGGTTAACCTCGCTCTTAGCGCCAGTAATGTTCACAACTTCTGGATCACTCTTTGCTGTGCCAAGATTATACCCATGAGATACAGCACTCTTATTATACTCTATTTGCACAGGAAGGGTACGAGATTTTCTCTTTTGAATGTTTACACGTACTTTACTTGGACTCACACTATAAGTTAATTGAGTACTTAAACCATTTACCTTAATTGGCACCGTATGTTCTCCAGTTTTTAAATGGCTTAAATCAATATAAACACGGAAATTTTGAGTATTAATAGTAGAAGTAACCAGCGCATTTGATCCTTCTAAAGTAAGATTTATTTTTTCAGGATAACCAGTTACATAATATTTATCCGTATTAACAGAAACTTGTAGAGGAGCTTTAATTACTTGCGTCTTAGTTGCAGTTTTCAAAGTTTCTTCTCGACGTCCTTGAGTTACAAATCCCTGTTGATTAGACGAAACATAAATAGCCAGTAAAATTGCCAATATCAATGCAACAATGCGATAGAACCAAGGTTTATCAAAAAACTTTTTCATTTTTTATTTGACCCCCAATTCCAAACATGGTTTACAATTCGTTGATACCATTTCGGCTTTTCTTCTTCTTCCTTTGGAACTAGTTGAGCATTTAAGTACTTCAAATACTCTTCTCTAGTCAAATCAAGCATAAACTGGCTATTACGAGTAATTGTTACCCCACCAGTTTCTTCAGATACAACAATTGTAATCGCATCAGTAACTTCTGAAATACCTACCGCAGCCCGGTGACGAGTTCCAAGTTTTTTAGGAATCATACTATTATCTGAAAGTGGTAAATACGCAGCAGCAACTGCAATCCGATTATTTCTAATAATTACTGCACCATCATGCAATGGAGTGTTAGGAATAAAGATGTTGATTAATAACTCGCCAGTAATATCTGCATCAATTGGAATACCTGTTTCAATATAATCCTCTAAACCAGTATTTTGCTGAATTGTAATTAAAGCACCGATTCTTCTTTTGGACATATATTGAATCGCCTTATCTAGTTCTCCAATCATTTTTTCAGCGGCCTGTTTTTCAGTCATAGTTGTGCCACCAAAAATTGGCGATCTTCCTAAATGTTCAAGTCCACGTCTAATTTCTGGTTGAAAAATAACGATTATTCCAATTACAGACCATGAAAGAATTTGATCAACGAAATACGTTAGTGTATGTAAGTGCAATAAACCGGCTATAATTCTAACTATGATAATTAGTGATATTCCTTTAACTAATTGAACAGCCTTGGTTCCTCTTACCAACATAATTAAGCGATAAATAATATACCAAACAATCAGAATATCAATAATATTCATTAAATTTTGCCAAGTAAATATTTGCTCGATGTTAAATTTCACTACCCATCCCTCCTAAACCTTAATTATACCTAAACTACTGTCTTATCGACCATACATTTTAAATTCAAGAAATAGATCATTATATTCCTGAATTTTCTTAGGACCTAAATCCTGATAGACTTGTAAATTTTTCATTGCTTGTTTACTTGGATAAAATTGCTTATCGTTTTTTATCTCTTTAGGTAATAATTTTTGAGCTTTGATATTTGGCGTTGCATAACCAATATACTCCGCATTTTGAGCAGCATTTTTTGGATCAAGCATGAAATTAATAAAAGCATATGCTCCTGCTTTATTTTTGACAGTGCGAGGAATAACAAAATTATCAAACCACAAGTTTGAACCTTCTGGTGGAACCACATAATGTAAATGCTTATTATCACTTAACATTGTCCGCGCTTCGCCAGACCATGTTACACCAACTGCTGCCTCATTCTGAATCATATACATTTTTAGCTCATCAGAAATAATCGCTTTTACATTGGGACCTAATCCATCTAATTTAGTTTTAGCTAATTTAAGATCTAATGAATTAGTAGTATTTAACGACTTTCCCATCGATGCTAATGAAAGTCCCATAATATCTCTAGCAGAATCAACTAATAAAATATTATGACGATACTTTTTTGACCAAAGATCGTTCCAGTGCTTTATTTGTCCCGGTTTTACAAACTTATCATTATATACAATTCCTAAAGTTCCCCAAAAATACGGGACTGAATAAGTATTCTTAGGATCAAATGAGTGATGCAAAAATTCACTCCCAATATTTTTATAATTTGGAATTTTTTTGGTATCAATTTTCTCAAGTAACTTAGCCTTTCGCATTTTCGAAATCATGTAATCCGAAGGAACACAAATATCGTAAGCGGTGCCTCCTTGCTTTATCTTCGTATACATAGCTTCATTAGAATCAAAAGTTTCATAAATTACATGATAGCCAGTTTGCTTTTCGAATTTTTTTATCAATTTAGGATCAATATAATCACCCCAATTATAAATAATTAAATTCTTATTATTGGCGCTAACACCGCTATTATCTAACTGCTTAGCCCAAGCCTCTAATCCCAAGCAAACTGCTAGAATAGCAAAAATTCCAATCAATAACTTTTTCATTGTGCACGCCCCTTACCGATATGGGATTTATGATTAGTAATTACATAATAAATTAATACCAAAACCATTACGAAGATAAACATTAAGGTACTTAAAGCATTAATTTCTAAATTAATACCCTGCCGTGCGCGTGAATATATTTCTACAGATAATGTTGAAAAACCATTTCCAGTCACAAAAAAAGTAACTGCAAAATCATCTAATGAATAAGTCAAAGCCATAAAAAAGCCAGCGAGAATTCCTGGTGTAATAGCTGGAATCATTACTTTACTATAAACTTGCCAAGTAGAAGCACCTAAATCTCTAGCAGCATCGACCAAAGAGTAATCAAACTCCTTTAAACGCGGCAAAACCATTAAGACAACAATCGGAATCGAAAATGCAATATGACTTAATAATACTGAACCAAAGCCCAAACCAATTCCTAAAAAAGTAAAAAAGATTAAAAAGCTGGCACCAATAATTACATCTGGTGAAACCATCAAAACGTTATTTAACGCTAATAATGTTTTTTGGCCTTTTTTATTTTTAGTCTGACTAATTGCAATTGCTCCAAAAGTTCCAATTACTGTTGCAATCAAACTAGATAAGAGAGCTAATAAGATTGTTTCTAAAAAAATGGCTAGTAGTCGATTATCGTTAAATAAGTCTTGATAATGACTCAAAGTAAATTTTTCAAAATGATCCATATTATGACCACTCGAAAAAGAATAATATATTAAATAAAAAATAGGTAAATACATCGAAACAAGGACAAAAGCAAAATAAATCCGAGACCATTTTATTTTTTTCATAGCTTGATCTCCTTTTTACGACGATGATCAGACGAAGTAAATAGCATAACAATTACCATCAATACTATTAATACAACTCCAATTGTCGATCCCATTGACCAATTCATCGTAGTCATAAAATATTCTTCAATTGCAGTACCAAGCGTAATTACTCTGTTTCCGCCAATCAATCTTGTCAACATGAATAAAGAAAGTGACGGAATAAATACTGCTTGAATTCCCGACTCAACTCCAGATTTAGAAAGTGGCCATAAAACCTTAATAAACGTTTGCCACTTACTTGCTCCTAAATCATAAGCAGCTTGAATTACAGCCGGATTAATATCACAAATTGCATTATAAATTGGCAAAATCATAAATGGAATTTCAATATAAGCTGCTACAAAAATAAAAGCAAAATCAGTAAATAAAATATTCGCTGGAGCGATGCCAAAAAGCCTTAAAAAGTTATTTAGTAATCCATGTTTGCCGAAGATTCCAATAAATGCATACGCTTTTAAAAGTAAATTAATCCAAGTAGGTAGAATAATCAAAAGCAGCCAAAATTGCTGATTTTTCATTTGACTTAAAATATATGCAATTGGGTAGGAAATCAACAACGTAATTAAGGTAATTAAAAACGCATACCAAAAGGAATTTAGCGTCATTCTCAAAAAAGTTCCATTGACAAAAAACTGCTGGAAATTTTTCAAGGTAAATCCATCATCACCTTTAAAGGCATTAATAGTAATTAAAATAATCGGAGCAATCACAAATAAACTAAGCCAAAGTACATAGGGTACAAGAAAAAATAGCCTGCTCTTTTTCATATCTTACTCGTCTCCTTCATATGCCTCTAAGCGTTTATCAAATTCTGCTTCGCTTTCACCAAAACGCATCACATGAATATCTTCAGGATCAAAATATACTCCTACTTCTTTTCCAATATTAGTTGGATTAGTTGAGTGAATCAGCCATTCATTTTCATCACTATCAATGGCTTTAATTTCAAAATGATCACCCAAAAAGAGCTGACTTTCAACCATAACTCTTAATTTTCCATGCTCAATATCAGTAATATCTAGATCTTCTGGTCTTAAAACAACTTCTACTTTTTCTCCTGGTTTAATTCCAGCGTCAGCACATTCAAAACGATGATTACCAAATTCTACTTCATAATCTTTAATCATTCTTCCACTCAGAATATTTGAATCACCTATAAAGCGAGCTACGAAATCATTAACTGGCTCATCGTAAATATCAACTGGACTTCCGCTTTGTTGGATTTTTCCTTCATTTAAAACAAAAATCTCATCACTCATAGCTAAAGCTTCTTCTTGATCATGAGTAACAAAAATAAATGTAATCCCCAGTTTCTTTTGAATTTCACGTAATTCAAATTGCATGTCTTTTCTTAAACGCTTATCTAAAGCCGATAAAGACTCGTCTAAAAGTAGAACTTTTGGCTGATTAACAATTGCTCTTGCAATTGCAACACGTTGCTGTTGTCCACCACTTAATTCAGAAATTTCGCGATTTGCAAAGCCATCTAACTGAACCATATGCAGAGCTTCTTTAACGGCCGATTTTATTTCTTGCTTATCCTTTTTCTTTATTTGCAAGCCAAAAGCTACATTTTCAAAAACATTCATATGCGGAAATAAAGCATAATTCTGAAAAACCGTATTAATTTTTCTCTTGGCTGCATCTAAGTTAGTAATATCTTTTCCATCAAAAAATACTTGACCACTTGTTGGTTCACTAAATCCAGCAATTATTCTTAAAATAGTGGTCTTTCCTGACCCTGATGGTCCTAGCAATGAATAGAATTTTCCTGATTCAATCGTCAAATTAATATCTTTTAGAGCCACAAAACCATCATCATACTCTTTACGTACATGCGTTAATTTAATAATATCGCTCAACTTTTTCACCATCTCATCAAAAAAGCTACAAGCCGTTACTTGTAGCTTTGTCGTAGTATCTAATCTTTTTCTTTTCCTATAATTCTTACTTCAGTCTGCAAATCAACATCAAAATCTTTTTTGATTGTTTTTTGAATTAAATGAATTAAATCTAAATAATCAGTAGCCGTAGCACCACCAACATTAACAATAAAGCCAGCATGCTTCTTTGAATCTTCCGCTCCACCAATTCTTTTTCCTTGAAGACCAGCTTTAATTATCATTGGGCCTACAAAATGACCTGTTGGACGTTTAAAGACACTTCCACAAGAAGGATATTCAAGTGGTTGCTTTGCTCTACGTAAGCCATTGAAGTATTCCATTTTAGCCTTAATTGCCCACTTATCTCCTGGTTCAAGTCCAAAAGTAGCACTAATTACAATATCTCCAGTTTCCTGAACTAGTGAATGACGATAGCCAAATTCCATTTCATCGTGAGTATAAGTTTTAAATTTGCCTTCACGAGTTAAGACCCGAACAGATTTAATGACAAATTCCGTCTCGCCGCCATAAGCACCAGCATTCATGAAGACGGCTCCGCCGACGCTGCCCGGGATTCCTGCTGCAAACTCTAAGCCACTTAAACTAGCTTCACAGGCTGCTTCAGACGTATCGATAATTCTCGCTCCAGCATCCGCAGTAACTGTTGCTTCTTCTTGATTTGCAACAATTTTATCCATTTTAGTAAGAATTAAAACTAGACCCGCAATTCCTCCATCTCTAATAATTAAGTTAGAAGCATTTCCAATAACAGTTAAAGGTAAGTTATTAGTTTTAACTGTTTCCACTAAGATTTTTAATTCTTCTAAATTTTTAGGAAAAGCAAGATATTGCGCAGGCCCACCGGTCTTAGTAAACGTAAAGCGGCTCAATGGAATATTTTCTTGAATATCAATTCCCTGTTTTTTCAAATCCATCAGTTGCATTTTCAATCTCTCTTTTCCTTAAATAATCGTCCCTTTAATCATACCGCAATAAATAGCTAGTTTTCTACCTTAAGTGTTATACTAAAAAGAAAAATAATAATTTATTTAGAGGATAAAAATGAACTTTACTGCAATGGATTTTGAAACGGCAAACAGTCATCCTGAAAGTGCATGTTCTCTTGCCTTAGTTATGGTTAGAAACAATGAAATTGTCGACCGTTTTTATACAGTTATTAATCCGCAAATGCCTTTTGATAGTCGAAATATCAGAGTTCATGGTATTACTGCCGAAGACGTTAAAAATGCACCAACAATGGCTGAGGTTTGGCCTAAAATTAAAAAATTATATCAGCCGGGAATGTTAGTAGCTGCTCATAATGCACGTTTTGACTGCCGGGTGATGGAAAAGTCACTTGCTCGCTATAATATTCCAGCCCCTCACTACTTTGCAATTGATACTTTAGCAACTAGCAAAGCATTTGAACCCAATCTTCCTAATCACAAATTAGACACAGTTTCAGAAGCTTTAGATATCAACTTATGGCATCACCATAACGCTTTAAGTGACAGTGAAGCTTGCGCAGGAATTTTAATTGAAGAAAATAAACGTGTTGGGGATGATCCAATCAAAAAAATGGTTAAGCAAATTTAAGCTTAACCATTTTTTATTATTCAAAAGATTTTTTTATATCTGATAACCAGACTTGGTTTCTCTCACCAACAGTTTTAAATTCAACTATTCGTTTGGTTGAATCCCACGAATCATCAACACGCTTAATCGTTAATTCAAGATAATCATTTGGCAGATCATCAATAATAAATTGTGGCCATTCAATTACCACTAATCCATCTTCTGCTAGATATCCAGGCATATCAATACTTGATAAATCACCATCTTCTAGTCGATACATATCCATATGAAAAAGTGGCATTTTACCTTCACGATACTCTCTAACAATTGTAAATGTTGGACTTTTTACAGGACGTCTAATACCTAATGACCGAGCAATTCCTTTAGTCAAAGTGGTCTTTCCAGCACCTAAATCGCCAGATAAGAGGAGCAGATCATGCCCCTGGCTATTTTTTCCAATTGCCTGGCCTAATTTTTGCATTTGTTCATCAGAATTTATTTCTAATGATTCCATTTTACTTCTCCATATTTGCTTGAGCAGCAGTTAAAATAGCTAACAAGTATACATCTTCTGTTTTACATCCACGTGATAAGTCATTAATTGGAGCAGCTAATCCCTGCAATACAGGTCCAATTGCACTAAAGCCACCTAAACGCTCAGCAACTTTATATGAAATATTACCCGATTGAAGTTCTGGAAAAATGAAAACATTAGCATGTCCAGCAACTGCAGAACCTGGAGCTTTTGCTTCTCCTACTCGTGGAACAACAGCAGCATCAAACTGTAATTCACCATCGCAAACTAAATCTGGATACTTTTGATGTACTAAATCTGTTGCATCTTGAACTTTAGTTACCATCGGTCCCTTTGCTGATCCCTTAGTTGAAAAACTAAGCATTGCAATTTTAGGATCAAGCCCAACCATTTCAGCTGTTTTACTGGATTGGTAAGCAATTTCAGCTAATGTCTCACTATCAGGATCAATATTAATTGCACAATCCGCAAATATATATTTTTCGTCTTTGCGTTCCATAATCATAGCGCCAGAAACACGGCTCATTCCTTTTTTAGTTTTAATAATCTGCAAAGCTGGGCGAACCGTATTAGCTGTTGAATGAGTAGCACCGGAAACCATTCCGTCAGCCTTTCCTTCATACACTAACATTGTGCCAAAATATGAAACATCTTGTAGAATTTCCTTTGCTTCTGCCAAAGTATTCTTTCCTTTTCTTAATTCAACAAAATCTTGGCACATTTTTTCAAAATCTGAATAGACAGCTGGATTAATTATCTCAATTGAACCTAGATCAACATTTAATTTCTCAGCAGATTTTATTACTTCATCAGGTTTTCCTAACAAAAGTGGTTCAACAATTCCCTCTTCTGCGAGACGAACAGCAGCTTTAATTATTCGCTCATCATTTCCTTCAGGAAAAACAATCACTTTTTTTGATTCTTCTGCTTTTTTCTTAAGTGAGTCAAATACTTTCATAACAAATTAAGCCTTTCTTTTTATCTCTAGCTAATATTTTACAATTTCAATGCTTTTTCTCAAAACAAAAACTATGCCATATCTGATTGACTTACTTCCTGTGGCAATTGCCAATCAATTGGACTCTCACCAAATTTAGTCAAGGCATCATTACATCTAGAAAACGGACGAGAGCCAAAGAAACCACGGTCTGCTGAAAAAGGACTAGGGTGTGCAGACTTGATAATTACGTTCTTTTCTTCATCAATTAAAGGAATTTTATTTTGGGCAAATCTTCCCCACAAAATAAATACAACTTTTCCGCGATCACTAAGAGCTTTAATAGCTGCATCAGTGACTATTTCCCAGCCTTTTCCCTGATGACCATTAGCATTTCCATAAGGCACTGTTAATACTGCATTAAGCAATAAAACTCCTTGATCCGCCCACTTTTTCAAATAGCCATGATTTACTGGGATGGCACCAACATCATCATATAATTCTTTATAGATATTTTTTAACGATGGTGGCAAAGCAACCCCAGGATTAACGCTGAAACTCATCCCTGTGGCTTGGCCAGGGTTATGGTAAGGATCTTGACCTAAGATCACAACCTTCGTATCTGCAAAAGAAGTTAACTTAAAAGCAGTAAAAATGTGATACATATCTGGAAAAATCTGCTTTGTTCGATATTCACTTTTTAGAAAATCATGTAATTTTTGATACTGTTCACTCTCAAAAGCGGGTGCCAAAATTTCATCCCAATCATTTCCAATTAATTTTTTCATATTTATTCTATCCTCTTGTATCTCTAAGAAATCCAAGTTCATGATATCATATAGATAAAAGATCGGAGGACTTAAAATGATTAAACTTATTGTAAGCGATATGGATGGCACACTATTAAATAAACAAATGCAGATTTCTTCTGAAAATATTTCTGCTATTAAAGAAGCACAAGCTAAAGGAATCGAATTTTTAGTAGCAACTGGACGAGCACCTTCTGAATCTCAAGGAATACTGGCTAAAGCTGGACTTCACACTGGCTTCATTAACTTAAATGGCGCAATGGTTTTTAATACAGAAGGTAAACTAATTGTAAACGAGCCAATTCCTAAAGAAGAGAG
+>1_1#NODE_10_length_39995_cov_63.156_ID_19
+TAGATGCTCAATGTGACATATACCACATCCACAATATACCATAATATGACAAACACCACAAAAAGTTCCATCCACAGAAACGCATTGCTGCGGCGCTCGTTCCATATCTGTTTCAATAAATTCCTGTTCATGATCTAACGTTGGTTTAAAGCGTCCGTAATATTCATGCGCGATGCCCTCCAGGCAGGGATGCACGCTGACAGCAAATTCAAGAGAAGGCAGAAAATGAATGCGGCCAAGAATATCCAGGGACTGAACAACATATCTGCCGAAAGACTGGTTTCTCCTATTTGGGCACGGTTCTCGCTATTGGAAAATAAGAAATCATTCAATAAAAAAGTACATGCATAACTGAAAAGCATTCCTACTGCTCCGGCTATGAGCGTCAATAATAAATTTTCATAAAACACTTGCCTCAACAAGACATTGGCAGTAGCACCAAATGCCTTCCTCACCCCTATTTCCGACATGCGCTTCCGCATACGGGACAAAGTCATGCTACTCAAATTTATAGCCGGTACCAGCAATAAAATAACAATCACCAACAGGTAGTGCAAATAAGCTTCCTTCGCCTGTAACTCTCTTCCCCAGTGACGAAAGATAAAAGAGAAACGATCATCGGGTTGTCCACGATAAAAAATTTCGGAATCCTGCAATCCGTCATTGAATTTCTGACGCAGGCGTTCCGCCTCTTCTCTGATGGCAGGAAAATCTTTCTCCGAATGTGCCAGAATGACCACACGAAAAGTTCCCATCGCATTGTCATACCAGCACTTCCTGGCTATTTCTGTTGAATTGAAAGGTATCCAAATCTGCGCATAAGAAGAAACAGCCAGTTTGGATACATCTTTCACAACACCCACTACCGTATAATCGGCCAAGTTGAGTTGGACCGTACGTCCTACCGCTTCTACCGTACCAAACAAATTCCGGGCCACAGAAGCACTAAGTACAACCTTAGGAAGTCCGCTTTCACTATCGGCAGCCGTAAACGGCTTTCCGGCAATAAAATCAAAAGAGAACACTTTCCAAAAGGTATCGTCAGTTTCAAGGTTATCCACTGTCATCATTTTTCCAGCAGGTACAGAAATACGCATCCTGCCTCCTGTAGACACTATAGTTACCGCCTCAGGAACAGTAAGTGCCTTAAAACACTCTTTAGCCACTGTGAGTGACATACAGCCGTTTGATGAATTATCACTGGTATCTCCTTTCTGATGAATAGACATCGCTTTCATATAAAGAGAACGTGAACGGTTCACCTCGGGCACACAATCCGTAATGCGTACTTCCAACACCAGGACAATGACCATGATCATACAAATAGCCAATGCCGTTCCTATGATAGAAACCAAGCTGATGAGCCTATTCTCACGAAGTTGGTAAAAGCCTGTTTAATATATAGTTTTATCATGTTTGTGCTATGCTCTAAAACCTTTTAACAAAAAAGAGATTACTCATTATGCAATGCTTCCGCCGGCTGAACTTTCATAGCCTTACGTGCGGGAATCCAAATGCCTACTACAATCATCAATGCAATCAAAATAAAGGAAATAAGAACTGTTATTATGAAACGTCCACCTTCAATAGTAGTGCCATTCATCCAAGCATTCAATTCACTATTTGCCAGATTCCAATCAATAAAAATCGCAGGAATTGTGGCCACCGCCAATAATATCAATCCCTCTGCCAACTGACGGACAAAGATACTATGATCTGTTCCACCCAATGATTTCATCAATGCAATCTCACCACGTCGTTGCTGAGTACGGAACCAGAAAGTACCTAGCAATCCCAAGAATATATTCAACAACAAGAAACCCATTCCGAAAAGGTAACTGTTCCAGGCATTCGTATGTGACTGCTGAAAGTTACGACGGATATCGGTAAAAGAACGCACATCCGCGATAAACACATTGCCCACGCGATACAGTTTCTCACTATCCGCTTTCAAACGGGCTATAAAATCGCGATCTTGATCCTCTTTTACGCGTACACAAAACTCCGTGCCCAAATCATACCATTCTTCCGGCATAGGAGCCACCATGCAGTAACTGTTCCATGCCTCAAAATAATCCCCATAACGGACAACCTGCAAAGAAGCCGCTAAATTATATGTATTCGTTGTATCCCCGAACAAATAAAATTGTTTGTCTACCAATGAAGTCAAATCACATCCATAGCGCCGTTTATAAAGATTATCTGAAGCTAAGAAATTCTTCGGATGTTTCAGCATCTCAGCCAGTTGTTCAGGGGTCTCCCCACGGGTGCCACGATAACGGAACACACGGACAAAATCGGGAGACACCAATCTGCGTATAGTCCATCCCGGCGAACGTAATGTATCATACACCACTGACGCACTGCTGTTACTGCCATTATACGGGTAAGAATTTTGTCCTAATCCGGCTGCCTCTATGTCCGGTCTATGCTGAAGACGACTTAGAAGTTCCTTGATATCCTGCCGCTTTTCCTCGTCTGTCTGATTGGGAATAAAGTCTGGACTTTTGTCCGTAAGACGTCCCATTTGCACCAAATAGCAATGAGAAATATCAAATCCCCGTGGTTCATTATAAATTGAGGTCTGTACATACATATAGTCCACAATATACCATAAAACGACACTTACCAACAATAATTCGGTGACAAGCCAAAGATTAGACCGCCATTCATTTTTTATCTGAGTAAATAGTTTCTTATTCATCTTGATTCTTTACTTTTAATTCGTTATCACCTTAGTGAATCCTTCCTCCCAGTGCATTGACAATGCTAGTCCTTGAAGCCCTCCAAGCAGGAATGCCGCTACTCAGCAAATTCAAAACAAAGCAAAACAGCAATGCATAAAGGAAAGTGGAAGGGTGCAATAAAATACTGGAATCAACTGTAGGGGCATTCAATGTCGCACTATAAGGCTGTGCAAACAGGATATCGGTACCTAAATAAGCCATAACAATACTGATAAACAAACCTACGGCACCAGCCAACAAAGTCACGACCAGGTTTTCCATGATTATTTGTCCAACCATTTCCATGCGGGTGCTCCCAAAAGCACGGCGTACTCCTATTTCCGCCACACGTTGGCGCAACCGGCTTTGCGTCATACTGCTCAGATTTATAGCAGGTACTAACAACAGAATGATAAAAATGATAGCACGTTCACGACGAGCCGACTTCAAATCCGGCTCCAAGTTAGCTGCAAATGAAATAGACTGAGTTTCCTGATCGTATGGCCGGTTACGGTCTATCAACGTATACCCCTGATCGGCAAGAATAGAATTATACTCACTCATACGCCGCTTGGCTTCAGCACGGATTTCTCCAAAATCATCATGGCTTCGAGCCAAAATAGTGACACTCATCATCCCCATGTGCTGGTCACTCCACGTATCATTAGGCAAATCCGTCGAAGTAAAGGGAATCCATACTTGGCCATAAGAAGCATCGGCAAGAGTAGATACATCTTTCACTACCCCTACCACACGATAGGGAGCATGATTCAACAAAAACTCTTTGCCCGCAGATTCTGTGGAACCAAACAAAGCCCGCGATATGCTCTCAGTAATCACAGCCACAGGAGTGCCTGCATTGAAAGTAGCTTCATCGTATGGTTTTCCATTCACAAAACGAAAATCGAACACTTTAAAAAAAGTATCATCCGTTTCCCGCACATCCGCTCCAATAGCCGGCATAGCGGGTAATGAAACAGGAGTCGATACCGGCATACTGCAATAAATAGTGACAGCTTCAGGGGTTTTCAATGATTTATATATCTCACGCGCTGTCCGCACACTCATCGGTCCGTTACTTGTTCCGTCCCCCCAATCCTTATGACTAATACTCATATAATGCACATGCAGAAAACGATCCCGGTTTGACTCGGGAGAAAAAGGAGCGACCTTCACTTGTTGTAGCATCACTACCAACATAATAAGGAAAATGCTAAGAGCAGTTCCTGCAATGCTGATGACACTGATAAGCGGATGCTGGCGAAGTTGCGCCAAAGCTTGCTTAAAATACTGTTTAATCATCTCTGTTATTTCTTAATAAATTCCTTTTCATAGTAATCAGTAGTTATTGCACCTGACGCCCATCAAAGAAACGAATGGTTCTGGAAGTCTGTTTGGCTTGTTCTTCATTATGGGTTACCATCACAATGGTCCGTCCATCCTCTTTATTTAATTTATGCAACAATTCCATGACCTCTGCACCCATCTTTGAGTCCAGATTACCGGTAGGCTCATCCGCAAGAATAATTTCAGGATTACCCACAATAGCACGGGCTATCGCTACACGCTGGCACTGTCCTCCGGAAAGCTGTGTGGGCATGTGCCGCATACGATGACTTAAACCGACACGATCCAACACTTCTTTTGCCAGACGGGTACGCTCCTTGGCAGCCATCTTTCTATAGAGCAAAGGCAACTCCACATTGTCAATCACATTCAGCGAATTAATCAGGTGGAACGACTGGAATACAAAGCCCAAGGTCTTGTTACGGAAAGCAGCCAGTTCCTTGTCCTTCATGCTTTCTACAGACGTGCCGTTTATTTCAATCTTTCCACTGCTGGGAGCGTCCAGCAGCCCCATAATATTCAGCAAGGTAGACTTGCCGCAACCGGAAGGACCCATAATGCTGACAAACTCCCCTTTAGCCACATCCAAATTTACATTTTCCAGCGCTAATGTTTCAATCTCATTCGTACGGTAGATTTTATTGATACCGGTTAATTTAATCATTGCCATATTTTTTTCTTATTTAAATTGTTAATCTTATACACTTTCTATTTTCATGAATCAAAAGACATTCCAAAGCTATAATCATTTAATATTCAACGAATTTTAATTCTACATACTGTCCGATAACAGACGGTGTGACCGTTTTTACCGGACTAATACGACTGATGCTGTATGCCGGAAAAAAATGTCAACAAGCACTATGAATAATATAAAAAGGTAAACGATCAAAAAAACGACATAGCCTAAGAACAAATTAAATTATGTTCGGGAAATGAGTGAAAAGGATGAAAAAACACTTCATTTCCCGTAACAATCAATGTATTAATTAAGAGAGAGTTTTATCTTGTTGTTTATGTCATAGCTGCTTCTTATTTCAACTTCAGCTTATTCTTGTTTTTGTAACTGCTCATATCGCTGACAACCACCTTGTCACCCGGTTTCAACCCCGATATGACTTCCACATATTCAAAATTACTATCACCCAATTGAACCTTACGCTTTACTATTTCATCCTTACTATCCTGAACAAATAATTCATACTCACCGCGACCGACATAGTAAGAAGCATTCGCCAATCTTAAAACCCCTTCTTTCACGGCATTCATTACATATACATCCGTCTTCAAGCCGGAACGCAATCGCTTGTTATTATCTTCATTCAATTGTACAATAAAGGAAATCACCCCATTCTTACTCAACGGTGTCACACTACTTACCGTTCCTTCCAGTTTCTCATTGCCAATCTTGACTATGGCACGTCCACCTGCTGCCACACGGTCACCGTATGTATCGGCTATTTCACCTTCCACTTTAAAGTGGCTCAAATCAGAAATGATAGCTACCTGGCTGCCTTCCGCTACCTGCGCACCTACCTGATTATTTATATAGGTAAGAATCGCTTTACGCGGTGAACGAATTTGAGCGTCATCCAATGTACGTTTCATTTCAGCAAGACTCTTTGAGAAAATATTGAATTCCAATTCCTTCACTTTCAAATCAGCCTCTTTTACTTTCGATTCATTCGCGTATTGCTGACGGAGCTGTTCCAATTCCAATTTTCCGGTATTAAAGTTCAGTTCAGCCTGACGAACCTTGTCCGTTGTTCCAGAGCCCAAACTATCCAAATAACGTTCGTTACGAAGTTCCACCTCCATACGGTTCAATTTCATGGCGGAAATTTTCACTTGCATCGATAAATCACTCAGATACGTATTATTATTCACTTTCAACTGCTCTAACTGATAACGTTTCATCTGTTCTTCATCCAGTAATTTCTTGTATTCAGTTTCCGTACTCTGCAAATCAAGTTTCAAAATCGGCGTACCTACATCCACACTGTCTCCTCCCTTACGGTAAACTTCCACGATACGAGTATTAATAGGTGAGTTGATAATCTCTTCAAAAGCCGGAACAACCTTACCGGAAGCACTGACACTTACTTCAATAGTTCCATTGTCCACTTCTGAAAACACCAAATCTTTCCTATTGACGCTGCTTCGCATAAACGAAATCAATACAGCTATACATACCACTGCCGCCACACCTATTGCACCATATTTAATGAACTTCTTTTTGCGCTCCTTATCACGCACTTCTTTAGGAATTTCTCTGTCCATAACTTATTGTAATTTTATTATTATCATTTTTGTGCTAAAGAATAAACAACATCCGTGCCAAGGAAACAACTTATTGATAATCAATAACAAATAAAGCGTACAAGGTGTCCGATATCGGACACCCTGTACGCTTTTAAACATCAGTTACCGTACAATAATGATTAACGCAAACGCAATATATCACCTACTTTAGGAGAAGGGTCTTCCGGTTTCATCTTATTCATCTTATATAAATTTTTCAGACGAATACCATATTTTTGGGAAATGGAATACATAGATTCTCCCCCACGGACAACATGAACTATGTGTTCCTTATCCGCACGACGATGCTTTTTATCCAAATAAATAATATCACCTGGCTTCAATACATATCCCTTATAAAGATCATTGTATTTCCTCAACTTGCGTTGACTGATATCAAATTCTTTAGAAAGTTTTTTAAATGTATCCCCCGGACGTACCACAATATAGAGTAAATCATTAGCCAAATAAGGCTGATGCGGGTTTGGGAATTCCTTCATCCACTTTATACCATCCTTGGTATCATACTTATGTAATTCATATAATTCAATGATATCAATTAAACGATATGCATAGCGAGGGTCAGTAGCATATCCCGCTTTCTTCAGCCCATGCGCCCATCCTTTATAATCGGTGATTTTTAATTTAAAAAGAGATGCATAACGTGAACGTCCTTTTAAAAATTTAGAATGATCTTCATATGAATCACGAGGGTGCTTATAGGCACGAAAACATTCATTACGGGCATCATCATCATGCCGTACAGTACGACCAGTCCAGTCACCACCACATTTTATACCGAAATGATTATTGGATTTACGAGCCAGTGTACTTTTTCCCGCTCCTGATTCCAATAATCCTTGAGCCAGAGTGATGCTGGCAGGAATACGATACCGTTTCATCTCATCGATAGCGAGATCTTTATACTTATGAATATATTCCTCATACTGCCGGTTACGGGTTTGCGCTTGCACTGTAAAATTACATAGACAACAAAACAACCCGATTAATATAAATTTCAACGTATGTTTCATCATATAAAACTGTTTCAAAATCGCGACTATACTTTTTCCGCTATATATAGTTGCAAACTTACCATTTTTATCCGGCTGTATGCAATCTTTTTAAATTAATTACGAATTTCATTCGAATTCCAAAAGTCCAAAGAAATCCGGACGATGAAAATCCGGCTTCTCTATTTTAATAGGATTCCATGATAAGAAATGAGGCTTTTGCAATTCATCTCCACATTTATAAAAATTAGCCCGTATGCTCATTCCATCCAGCCCGGTAATGGCATGCTTAAAAAATACCTTATACGGAATCAGCAAAGCCACCTCCCAAGTACATTCTCCTATCTTTTCTTCAAAAGTTTCTCTGCCCAAGCTAGCCCAACGCTTCACCTGATCCGTTATTTCAGAAGGAGCCATTTCACGATTATTACGCTCCGAACCTGCTGCTAAAAGAATCGTAGCGATACAGTTACATTCCAAATTATAATAAATGCCATCTCCCGCAGGAATAGAGAAAAATTCCACGCAGGAATCTGTCCAAACACTACCGTTATCTTCACCGTATTTGGCACGAACACTGTCTTCTACTACTTTATAATGGACTAATATAGCATCATTTGTATAGGCTATACGAAAAGAGACTTGAGGTTGATAAGGATATTCTTTCCAGTTCACTATATTAATAGGATGATACGTAATGTTCTCATTATCAAACAAGGTCGGTATTTGTCGTGCATCTTGAACTTTACCACTTAATTTCTTTACTTTCATCGTATTGTTTTTATTAGTTAAATAGCTACTATTAGCTTCACAAAAATATATACTTCCACTGAGAAAACAAAATAGTGGCTACCATAAACAGCAGCCACTAAAAGAATAAAGCAATAAAGACAATGAAAGCACAATTTTTACATTTTCATCCATATTTATTTCTTCACATCGCCCTGTGGCATATGTCTTCTCCCATCATGCTGCTTTTTCATTCCTTGTCTTTTTCTCATCTCTTTACGGAATTTATCGCCATTGTGTTTCTCCATATTATACATTTTCTGAATTTGTTTAGGAGAAAGAAATTTCCGGAACTCATTATAATACTTCTCACGAACATCCAGTATCTTTCTACTCTGCGCGAAACGTGCCTTGATAGCCTGCTCCACTTCAGCATCTGTAGGAAGCGGTTTGGGGGTCTGTTTATCTGCAGCCGTTCTATTTGCAATATTTCGACAGGCTCCCATATGACGAGTAGCCCGCATTTCTTCCATGTATTGTTTATACACCGGAATAAATTTAGCAGTCGTTGCGTCATCCAATGCCAATCCTTTTATAATTTGATTGCACTGTATTTCCAGCATCTGCTCTTTATTAAACTGCCTTCTTTCAGATTTAGCTCCTTTCTTTTCTTGTGCAAAAAGTGTTACCTGACTTCCCATAACAATGGCTGCCAACATCATTAAAAAAAATTTTGTTCTCATCATTTTTTTGTTTTTAGTGATTAATCAATTTATAAATATATCATTTTCAGACAATTCCACCCATCCTGCTAATTCCTCATCAGACATAGATTCTATATAACGATCCAAAGTATCTGAATAAGAAGAGTCTAAATCCGTAGAAACAATAAGTGAATGAGAAGGCAACTCCTCTGCCACAGGTTGGGATATCGGAAAGAAAAGAACTCCCAACATGACAGCCGCAATAGCTAAAGCAGCCCCAATAATCAATTTTATTCTATGCTGCCTATTAAACCTCTCAGCCTGTGTACGCTCCAATACTTGCTTCTGCATTTTTCCGAAAAAGCCATCAGGGGTACGATAAGGCATCCGCTTCCCAATATTCTTAAAATCAAACTCCTTTTCCATCCTGTCTTTAATTATTTATCATGTACTCTTTTATCTTCTCTTTTGCATAATGATAATTCACTTTCAACGTATCCACTTTCGTGTCCGTAATCCTGCTAATTTCCTCATATTCCAGTTCATCATAATAACGAAGATTGAAAACTACCCGCTGCTTTTCAGGAAGCATCAAAATAGCCTGCTGAAATTTCACCGCCATTTCGTTCTCATAATCCACATAATCTGACGCCATCAACTTATTCATTAACTCTTCCTGAACTTCTTCCGCCGAAACAGCTTGTTCCTTACGCATATTCAGAAAACGGAAACACTCATTGGTCGCTATCCGGTAAATCCATGTTCCCAATGAACTTTCCTCCCTAAACTGAGGAAGATGGCGAAAGACGCGAATAAAGACTTCCTGCAGAATATCCTCTGCATCCTCATGTGATACAACCAATCTCCGGATATGCCAATATATGGGCTGTTGAAAAAAATCTATCAACAGTTTAAATCCCCGTTCCGGGTTGGAAGCCCATACTTCCCTAATTTTATCTTCGTTTATCATCTATTCGTCAAAAGTTTATAGGTTAGAACCACCCGAGAACAAGAAGTTAAAAGTGAAAATGAAGTTTTTACATTAATTATAGATGAAGTTAAAATAATCAATCACATTTCCTACAAGAGAAAAATACAACCAATCTTCCGGAATATGAATTTAAAGAATTCAAACTCAATCTTCCTATCAATAAATTTCAGTTCTTAGAAGAATTACCATATAAACAATAGGGAAATCCCTAAAAATAAATAGGGGAAAAGATAGAAGAATATACCTTTTCCCAACTTATCTTTGTTACAAACAAAAAAACAAAAAAATGAGAAAATTGAAACAAACATTATTAGCGTTAACCATTTGTACTTTAGTCATCAGTTGCAGTTTGACTACTAGTAGCACTATTATGAAAGTACAGAGAGGGATGTCCCAAGAAGAAGTCAGCCATTTACTTGGGAAACCCGATTTCCGTAGATTCGACAACGGCTCGGAACAATGGGAATATACCAAGACCAATGTGTCCACAGCTGCAAACACGGTAATTATTATCGATTTTGTAGACGGAATGGTAACAAACATGGATTCTTTTGAGTCCAACATTACTCCGCCTCCAGTTGCAGTGTGTCCGCCAAATGAAATCATTACGGTAGTTCCACCCAACCACCCTGATCATTCTGGCCCGCACAGACCAAAACACAAAGCCATGAATCCACATGATTTTGAAAACCTCTACAAAAAAGTAAAAAACAAAGCATTTAAGGACGACCAAATGGAATTATTATCTGTAGGAGTTGTAAACAACTACTTCACCTGTAAACAAACTGCCCGACTCATGTCCATATTTACATGGGACGATGAAAAAATGAAAGTATTAAGAATGGTTTCCAACCGCATTGTAGACCGTGAAAATGGAAAAGAAATCATCAAGACACTGGATTCTTTATTTAAACAAGATGATGCACGTAAAATATTGGGAATCACTAACCAATGGTAATTCAACCTAAACAACACACAAAAACATAAATATATGAGAAAATTCAAACAACTATTATTGCTTGTTATCAGTATAACACTTGTCAGCTGTCATACCACAGGAAGTATCAAACAGAAAGCATGGAAAGTACAGCAGGGAATGACAACAGAAGAAATAGGCCAACTTCTTGGAAAACCCGATTTCCGACGTTTCGATGGTTCTTTGGAACAATGGGAATATCAGAGCGGAGGAATTGCAACGTCTTGCAAATTTCTAATTATCGAATTTCGAAACGGAAAGGTAACAAGCATGGATTCCTACAATGAAATAGCTAAAGAGACTTCAGTAGGAGACCTATATTCCAGCAAAATATCCCTCCATACCGTTGGTTCAATAGACGATAACGAATTTGAAAAGATATACAATGAAACAAAAAATTCCGTATTCAAAGATTCAACTCTGGAAAAAGCCATTATAAATAAAAAATTAAGTTGCGCACAATGCCTTAAACTTATGTCACTTTATACTTTTGATAATGACAAGTTAAAAATGTTACAAGTACTGAAAGACCATATAGCTGACACAACAAATTACGATAATATTGTCAACTCACTAGATTTCATTTCAAGTAAAAACAAGGCCAAAGAGATATTAGGAATACCCTAATACAGTAAAAGCAAACGTACCTGTTGCAATAAACCTAAAAAATATTGCAACAGGCACATCTGCTTTACCTCAATCTTCTATTCTGACAGCTGTGCCGCTTGCGGTTACCATCAGCATACTACCACTGTCCCCCACAGTTTCATAATCCAAATCCACCCCAACTACAGCATTAGCTCCCAATAAAGCAGCCTGATCCTGCATTTCTCGTAACGCAGTATCTTTAGCCTGTCGAAGTACTTCTTCATAAGAACCGGAACGACCGCCTACAATGTCACGAATACTAGCAAAAAAATCACGAAACAGATTAGCACCGATAATAGTTTCACCTGTTACAATGCCATAATATTTGGTTATACGTTTTCCTTCGATAGTAGGTGTTGTTGTTGCTAACATAATCTTTCTCTTTTTTAATTATATATTCATTAGACGCACAAATAAAAGAAAAAGTTGCAACTTTCTCCTTTTTTATCGGTAACTATATTATTCTTTTCACATTCAACTCTGACAAGCAATAAGAAAACAAATAAATTTAAAACCAGATTTTAGAAAAGAAACATTGGGAGATTAAAAACAAAACATTACATTTGCAAGAAAACAAAGAGGAACGTATCATGAAACAAATCAAACTGGAAATAAACATAGAGGCTTGCCATTATGACGAACTAACAGAGAAGGACCGCAAACTGATAGACGCCGCGTGTGAAGCAACGAAAAGAAGCTATGCTCCTTACTCACATTTTGCTGTTGGAGCCGCCGCACTGTTGGAAAATGATATCGTCATTACCGGAACCAATCAAGAAAATGCAGCCTACCCATCTGGTCTTTGTGCAGAACGTACCACTTTGTTTTATGCCAATTCTCAATATCCGGATCAAGCAGTAAAAACACTCGCCATTGCTGCCCGCACAGAAAATGGTTTTCTTGACACACCTATTCCTCCTTGCGGAGCCTGTCGGCAAGTATTATTAGAAACTGAAAAACGATATGGAAAACCTATGCGGATACTGCTTTATAGTAAGACTGATATTTATATATTAGAAAACGTAAGCGGACTTTTACCTTTATCGTTTGATGGAAATTATCTGAAATGATACCTACCATCCGTCTGCACAGCCAACAGTTAATAAATCCGGTTTTCAATAATCCGAAAGATCTTGTATCATGGATGGGAGGCATTCAAGCGCAAGATTACACCATGTCCAAATGGGCTATTGGTATCCGGCTAAAGGCAGGAAATCTGCAAACAGTCAATGAGGCACTGGCAAAAGGAGATATATTGCGCATTCATGTCATGCGTCCTACTTGGCATTATGTAGCTGCAGAAGATATACGCTGGATGCTGAAGCTTTCATCCCGACGCATCATTACTGCCAATGACTCTTTTGCCAAGTCCAGAGGACAAGACATTTCAGTTGACATTTACAACAAAGCAAACCGATTATTGGAAAAGGCACTAGCAGGACACAATCATCTGACCAAGCAAGAAATTGACAACGTATTTAAAGAAGGAGGGCTGGAAACCAATGAAAGATTATCCAACCGTTTCCTGATTCACGCTGAAGCTGAAGGACTTATTTGCAGCGGAGCAGATAAAAATAATAAAATCACCTTCGCACTTTTGGATGAGCGTGTTCCTCCAATACAAGAATTACATAAAGAAGAGGCGCTAGCTATCTTGGCACGCAAGTATTTTAGAAGCCACTCTCCTGCCAGTCTGAAAGACTTTGTATGGTGGTCCGGACTTTCGGTAACGGAAGCTAGACAAGGTATAGCCGCCATTGAACAAGAATTGCTTACTGACCGTTTCCTAGCACAAAAATTATATGTTCATCAGTCTTATAAAGAAGAAAAAACAACCGACATATTGCATATCCTTCCTTCATACGATGAATACCTAATCAGCTACAAAGACCGTACTGATGTATTGAACAAAGAATACCAACACAAAGCATTCAATTCTTTCGGGATATTCCGTCCGGTTATTCTGTACAACGGGCAAATAGTTGGAAATTGGAATAAAGTCATACAAAAACAAACAACACATATAGAAATGAACTGGTTCAAGAAAAATACAAAAATCAGGTACTGTCCAAAATTTTGTGTAAATGGAAACAGGATTCAGTTGTAAGTTTGTTCTTATATCTGGATTCTGTTTTCAAATATAAGCATAAACTGGTTCATAATCAATCCCCAGTTTGAAATAGGCATTGTCCATTTCTTTTCAATCTCCATAAGTGAAAGATACACGGTCTTTTTTACGGCATCGTCCGACGGGAATGAAAGCTTTGATTTGGTGTACTTTCTGATTTTTCCGTTCAGATTCTCAATAAGATTTGTGGTATAGATTATTTTCCTGATTTCCAATGGGAACTGGAAGAAAACAGTCAGATCATCCCAGTTGTTTCTCCATGAAAGTATGGCGTATGGATACTTTCCTCCCCATTTCTTTTCCAGATTGTCAAGTTCTGCGGCAGCAACTTCCTTATTAGGTGCATTGTAGATATTCTTCATATCCGCCGTAAACTCTTTCTTATCCTTATAAACGACATATTTACAGGAGTTCCTGATCTGATGTACCACACAGATCTGAGTGGATGACTGGGGGAATACGGTACGGATGGTATCTGTAAATCCATTCAGATTGTCAGTACAGGTAATCAGTATATCCTGCACTCCACGAGCCTTCAAGTCGGTCAGGACACCCATCCAGAAAGAGGAACTTTCCGATTTGCCGACCCACATGCCAAGGACTTCCTTCAGGCCGTTCTGTTTCAGACCGACACAAAGATAGACGGTCTTGTTTATAATCTTGCCGTTATCCCGTACCTTGAAGACGATACCATCCATCCAGACTATCAGATAGACCGGATCCAGAGGACGGTTCTGCCATTCCTGCGCAGCCTGGCTTACCTTGTTTGTAATAATGGAAATAGCTGATGTAGAGAGCTCTATTTCATAAATCTCACGCATCTCCTCCTCTATATCGGAAACACTCATTCCTTTGGCATACAGGGAGATAACAAGCTTCTCTATAGAAAGTCCCCGGCTTTCATGCTTGGGGACTGCTATCGGTTCAAACTGCCCGTTGCGGTCACGCGGAATGGAGATGACAGACTCTCCATGTCCGGTCTGAATTTTCTTCGGATAACTGCCATTCCGGGAGTTGCCGGTGTTGTTCCCTGCCACGGAATTCTTCTCATACCCCAAATGGGCATCCATCTCACCTTCAAGCATCTTTTCCAATACCTGCGCATGCAACTGATTCAGAAACCTGCTCACATCCGCTTCTGTCTTGAACTGGCTAAGGAACTCCTTGCTTAATACCTCATCAGGCACTACTTGATTCTTTTCTTTCATAATCTTTTTCATTTGGTAAATGTATAAAATAAAAAATACGGAACTCGATTTTGAATCCCGTATTTTCCATTTACACAAAATATTTTATAGTGCCAAAAATCAAAAAAGAATTACTTTCCCTAGCGGAGAGAAAATACCTTACTTTTTTCTCCGAACTGTAAGAAAATTGTAAATGGATTATTTCTGCGTCATCACATTTTAAAAATAATCCATTACATTTACATTATTCAGTATTGCAATATAAAACTCTCAGCCACTTTCAAGAAACGTTCATGACCTTTTTCATTCAAATGTGCAGTATCTGTATTATTCTTGCTGTTCTGAAAATATATTTTCCTAAAATGATCATTACTTGCATAAATTCCTCCTTTTCGGGCGCTGTCAAAAATAGGAATACTATAATTTCCACAAACCTCAATCATAGCATCCACCACTTTCTCAGCATCACTTCCTGCAAAATTTTTACAGTTCCATCGGGTAAAGAAAAAAATCTTAGCTGTGGGATACTTTTCAATAAGCCCTTCACATAGCATTGCCAGCCTCTCTTTAAATACATCAATACCGCCAATTGAATCCAATTTAAAACCATCATTGTGCCCACCCACAACAATAACATAATCCAAATCATCCGGCATTTCCTTATATCTTACATACATCGCTTCCCCCCAACGCGGGCTACTATAAGCAATGCTGCTGCCGTTCTTGCCATAATTTAAATATTCCATACCATGTTTCTCGGCAAATTTATAATGCCAGGTATTCTTAACAGGTTCCTTATGATTCTTCACATAACTATCTCCAATAATTCCCAAACGTTTTCCTTTCAATTCATCAGTCCTGACGGTAACTCCTTTAATAATTTGTTCCAACTGCTTATATACCTGTTGTCCCAAATACTCTGCCGAATGAGCCGTGAAATGAAGTCTGTCATTTAACAATTCCGCGCCTGACATATCTATCAGGTGCATGTTCGGATCTTCAGCAGCCAATTGCTTCATCGCATTCTCCACTTCTCTGCTGAAATATTTATTACTTCGGGCAACAGTACCAAAAATAAAAGGCAAACGAGAATAATCCTTTCCGGTTTTTTCTGTCAGATGCATACGCACATAAGCCACCATTGTCTTCAAGTTACGGTAATAATCTTTACTTTTAGCATAATCACTTTCCCCCTGATGCCAAAGAAATGCATCTATCTGATAGCCATCCTTCAGGCGGGAAAGAGTCTTGTCTATACACATGTCTATCTCTTGAATGAAAGAAAGCAACAAGGAGTTTCCTCCATCAGAAGTTGGCTTAGCCTGTGCCAGCCATTCAGGCGCCGCAGACCAAAAACGTCCCTTGGAAGCATTATAATCAGGTGCTATAGAAGTTCCGCCAACAGCCCATTTCACCACATAAAATTTCTCCTGCAACAACTGCTCCAACCAATAATATGTCACTGCATCAAAAGCCCACATATTATTTTTTCCGCTACGTTTGGCACGAGGCCAGAAAGGAATAAATTCTCCCTTTCCGTCATTCTGAGCTATCTGACAATAACGGTAGGCACCTTCGGCATACGTCAGTGTATCCGTAGCCAATGCTTTAATATATGCCGGCAAATCTTCATTAGGAGTTCGTCCATCGGTATTAGACTGTCCGGCAGTTATAATCACATGTACAGGATTGGAAGCCATCGTATTCAAGCCAACAGCTGCAAAAATCAAAATCAAAATTAAGTTTTTCATAAGTATCATTTCATGTTTTTAATGGACACAAAAATAATCCTAATTCTAATATAACGACATGGATTATCGTCCATTATCATAGATTTTTGAACTCATTATGGTTCATACAGAATGAGAATTGCGGCTAAACCATAAAAAAAGAGCCACAGGAACAATGGCTCCCAATGACTCTTTCTTTTTCAGCTCATATTTATAATTTAATTATCTCCATACATACGCGCACGCATTTCTTTAATATGATCAGAAGTGATGTATTCATCGTATTCCATCATCTTGTCAATGATACCATTCGGGGTCAATTCAATAATACGGTTCGCCACCGTTTCAATAAATTCGTGGTCGTGGGAAGAGAACAGCACATTTCCCTTATAAGTCTTCAGATTATTATTGAAAGCCTGAATTGATTCCAAGTCCAAATGGTTGGTTGGAGTATCCAAAATCAGACAGTTCGCATTACGCAACTGCATACGGGCAATCATACAACGCATCTTCTCACCTCCGGAAAGCACATTCACTTTCTTCAATACTTCCTCTCCGGAAAACAACATACGCCCCAAGAAACCTTTCATATAGACTTCGTTACCTTCGCCAAACTGGCTCAGCCAATCTACCAAATTCAAATCACTTTCAAAGAAATCCGTATTATCCAAAGGCAAATAAGCCGTAGTAATAGTAACGCCCCACGCGAATTTACCAGCCTGCGGAGTACGATTTCCATTGATTATTTCAAAAAAAGCAGTCATGGCACGCGGATCACGGCTCAAAAAGACAATCTTATCTCCTTTTTCTACATTAAAATTCACATCATTGAACAATACCATACCGTCTTCAGTTTCCGCACGCAAGCCGGATACTTCCAAAATCTGATTGCCCGGTTCACGATCCGGAGTAAAGATGATACCGGGATATTTACGGGACGACGGCTTAATTTCATCTACATTCAGTTTTTCCAACATCTTCTTTCGGCTGGTTGTCTGCTTGCTCTTAGCCACATTGGCACTAAAACGACGGATAAATTCTTCCAACTCTTTCTTCTTCTCTTCAGCTTTAGCCTTCTGGTTCTGCTGCTGGCGAAGTGCCAACTGACTTGATTCATACCAGAAGCTATAGTTACCGGCAAACATATTCACTTTACCGAAATCAATATCTACAGTATGAGTACAAACAGAGTCCAAAAAGTGACGGTCATGACTTACCACCAACACCGTGTGTTCGAAATTAGAAAGATATTCCTCCAACCAAGTCACCGTATCCATATCCAAATCATTGGTAGGTTCATCCAACAACAAGTTGTCAGGATTACCGTAAAGTGCCTGCGCCAACATGACACGCACCTTTTCCTTACCACTCAGTTCCCCCATCAACATATAGTGCTTGTCTTCCTTTATGCCCAATCCGCTCAACAAAGAAGCAGCATCACTCTCGGCATTCCAACCATCCAGTTCGGCAAACTTCTCTTCCAATTCAGAAACTTTCAAGCCATCTTCATCTGTAAAATCAGTTTTCGCATACAGTTCTTCACGCTGTTTCATAATGTTCCACAACACAGTATGTCCCATCATAACCGTATCCATGACTGTATATTCATCCCACTTAAAGTGATCCTGGCTCAATACAGACAGACGTTCGCCCGGTCCTAATACCACTGAGCCCTTAGTCGGTTCCAGCTCACCTGAAATTGCTTTCAAGAAAGTAGATTTTCCGGCGCCGTTCGCACCGATAACCCCGTAAATATTACCATTGGTGAACTTCATATTTACGTCATTATACAACACTCTTTTACCAAATTGAATGGCCAAGTTCGAAACTGTAATCATCCTAATATACCTTATTTATATAATTATTCTATTTTGGAATTGCAAAGGTAGGCATTTTAATTCAGAAAAGTATGCCAGTGTGGCAGAAATTCCGTACTTTTGCAAAATTATTACTCTAAGAAAACAACTAGGCACGAAATTTGTTAGCAGTAAATTAACCTAAAAGACCTGACTGTTATGAGTAAAAATAAGAAAAACAAAAAGTTTAATAAGAATATGAACCCAACAGAGAAGAACCAACCTCAAGACGAGGAAGTTTTGAAAAATCAGGAAGCGGCAGAAGCTGCCATTGATGAAGAAACTCAGAAAGAAGCAACAGAAGAACTGAACGCTGAAGAGAAGGTGAACAAGGAATTGGCGGAAGCTCAGAAAACAATAGAAGAGCAGCATGACAAATACCTGCGTCTTTCAGCCGAATTTGACAATTACCGTAAACGCACCATGAAAGAGAAGGCCGAATTGATTAAGAATGGTGGAGAAAAGGCCATTACTGCCATTCTTCCTATTTTGGATGACTTGGAGCGTGCAGTAAAGACTTCAGAAACTTCGGATGATGTAAAAGCAATGCGTGAAGGAATTGAGTTGATCTACAACAAATTCCTGAAAGTATTGAACCAGGAAGGACTTCAGAAAATAGAGACTGACGGTGAGAACTTTGATACCGATTATCACGAAGCAATTGCATTAGTTCCAGCTCCTTCCGAAGAGAAGAAAGGAAAAATATTGGACTGTGTACAAACCGGTTATAAGCTGAATGACAAAGTAATACGCCACGCCAAAGTAGTTGTGGCTCAATAAAACAGTATCATAAAACGACATGGCAAAAAGAGACTATTACGAAGTTCTGGAGGTGGACAAAACAGCCACCCTTGATGTTATAAAAAAAGCATACCGCAAAAAAGCAATACAATATCATCCGGACAAGAATCCGGGAGATAAAGAAGCGGAAGAAAAATTCAAGGAAGCTGCCGAAGCTTATGATGTGTTGAGCAACCCGGATAAACGCGCCCGTTACGACCAATTCGGACATGCAGGAATGAGTGGAGCTGCCGGTGGCGGTTTTGAAGGATTCGGACAAGGTATGTCCATGGATGATATTTTCTCTATGTTCGGTGACATCTTCGGTGGACATGGAGGAGGTTTCGGAGGCTTTGGAGGTTTCGGTGGTGGCGGACGTTCCGCACAACGCAAGTTCCGTGGTTCAGACCTCCGTGTAAAAGTAAAACTGAACTTAAAAGAGATTTCTACGGGAGTAGAAAAGAAATTCAAACTGAAAAAGTACGTAACATGTGACCATTGCCATGGTTCAGGAGCCGAAGGAGAAGGAGGAACGGAAACGTGTCCCACTTGTCATGGAACAGGAAGTATCACCCGCACCCAACAAAGCATTTTTGGAATGGTGCAATCACAAAGCGTATGTCCACAATGTAACGGAGAAGGGAAAATAATTAAGAACAAATGTAAAGCTTGTGCAGGAGAAGGTATTGTATACGGAGAAGAAGTCGTGGAAGTGAAAATTCCTGCCGGTGTGGCTGAAGGAATGCAACTTTCTGTCAATGGGAAAGGAAATGCGGGCAAACATAACGGTGTTCCCGGTGATTTGCTTGTTGTCATAGAAGAAGAATCCCATCCAGACCTAATACGCGATGAAAATGATTTGATTTACAATCTGTTACTAAGCGTTCCGACTGCTGCTTTAGGAGGCACTGTAGAAATACCAACTATTGATAGCAAAGTAAAAGTAAAAATTGAACCAGGCACCCAACCAGGTAAGGTCTTACGCCTAAGAGGTAAAGGATTGCCCAATGTCAATAGTTATGGTTACAGTAACGGTACAGGTGATTTATTAGTCAATGTAAGCGTATATATTCCAGAAACGTTGAATAAAGATGAAAAACAAGCACTAGAGAAAATGCAAGAATCGGATAACTTCAAACCGAATACAAGCATTAAAGAAAAAATATTCAAGAAGTTCAAAAACTTCTTCGATTAATTTTTATACTACAAAGTGTCACAGAAAGAATACCAGGTTTTATATCTGCCTGGCATTCTTTTGTGACACTTTGCGGTAAATAAAAACATTTGCCATGAATTACGAAGAAACATTGGATTATTTATATAATAGTGCCCCATTATTCCAACATATAGGAAAAGATGCATACAAGGCAGGATTAGAAAACACTTATCTTTTAGACAAGTATTTCAACCATCCCCATCGCCAATTCCGAACCATTCATATAGCCGGGACCAATGGAAAAGGCTCTTGTTCACATACTTTAGCCGCCATTTTACAATCAGCCGGATACAAGACAGGACTTTACACTTCTCCACATCTGATAGATTTCCGTGAACGAATCCGCGTCAACGGAATTCCTGTATCCAAAGAATATGTCATAGACTTTGTAGAAAAACACCGTGCCTTTTTTGAACCTCTGCATCCTTCTTTCTTTGAACTGACTACCGCAATGGCTTTCCACTATTTTGCCCAAAGCCAAGTAGATGTAGCCATTATAGAAGTCGGCCTGGGAGGACGAATAGATTGTACAAACATCATCCGTCCGGATCTATGTGTCATAACCAATATCAGTTTCGACCATATACAATTCTTAGGTAACACATTAGCCAAAATAGCCACAGAGAAGGCCGGAATCATCAAAGAAAAGACCCCGGTAGTTATCGGTGAAACCACACCCGAAACCAAACCTATATTTACAACCCGTGCTAAAGAAGTAAACGCTCCTATCTACTTTGCAGAAGAAGAACAGTTATTACACTCCTCCAGCATAAATGAAAAAGGTAAACGAATATATCAAACAACCGACTACCTCAATCTGGAAGGCGAACTGGAAGGGCTTTGCCAACTTAAAAACACCAATACACTTTTATCTGCCATCCGCCTATTAAAACAAGCAGGTTATCAACTTACCGAAAGCAATATACGCAAAGGATTCTCACAAGTATGTGAACTCACCGGCCTGATGGGAAGATGGCAAAAATTAGAAAGTGAACCGACTTTAATATGCGATACAGGACATAATGTAGGAGGTATTTCGTATATCATAGAACAATTAAAACATCAGAAATATGAACGATTACACATTGTAATAGGTATGGTAAACGACAAGGATATCAGTGGAGTATTGTCCATGCTTCCTAAAAATGCCACCTATTATTTTACCAAAGCCAGCGTAAAGCGTGCTTTATCCGAAAAAGAATTACAAAGCTTAGCGATGCAATCCGGGCTGCACGGAGATACTTATCCTGATGTAGAAACAGCTGTAACAGCCGCTAAAGAAAAGGCTAACAAAAATGACTTTATTTTTGTTGGAGGAAGCAGCTTTATCGTTGCGGATTTATTAAAATTTCACGTTTAGTCCGTTCACTTTTATAGAAAAAGTTTGGGAATACCGAAGAAAATCTTTTTATTTGCATTAGTTTTATACATAAAATAAAAAGATTTTCAATAACATGATAAACACATCTACTTCCGATGAGAATTTATGCGGCCTGAAACGGGCCGATTTTCAGACAACAGTGAACGGGAAACAAACAGACCTCTTCATTCTGAAAAATGAAAACGGAGCTGAAATAGCTGTCACCAACTATGGTGGAGCAGTATTAGCTATTATGGTTCCGGACAAAAACGGTAAATATGCCAATGTCATTCAAGGACATGATAGTATAACCCATGTTATCAATAGCCACGAACCTTTCCTCAGTACTCTTATCGGTCGTTACGGAAACCGTATAGCAGGAGGCAAATTCATTTTAGAAGGGAAAGAATATTCACTGACTATCAACAATGGTCCCAACTCGCTGCATGGCGGTCCTACCGGATTTCATACCCGCATTTGGGATGCAGAACAGGAAACTCCCCAAAGCTTGAAATTGCATTATTTATCTGCTGATGGCGAAGAAGGATTTCCGGGAAATTTGGATATTCACGTAACGTACACTTTAAGTAATCAAAATGAATTCATCATTACTTACCACGCTACAACAGACAAAACAACATTGGTAAATCTTACTCACCACGGTTTTTTCAGCCTATCAGGCATTGCCAATCCTACGGCAACCGTTGATAACAACATCGTAACCATTAATGCTGATTTTTATACTCCGATAGATAATGTATCCATCCCTACAGGCGAAATTGCCAAAGTAGAAGGTACTCCTATGGATTTTCGTACTCCTCAAAGAGTAGACAGTAGAATCAATGACCCATTCGAACAGCTAGAATTCGGTGCCGGATATGACCACTGCTATGTATTAAACAAACGTGAAGCAGGCACACTGAGTTTTGCAGCAAAATGTGTGGAGCCCGAAAGCGGTCGTAGCATGGAAGTATACACTACAGAGCCCGGTGTACAAGTTTATACTTCAAACTGGCACAATGGTTTCGAAGGTGCTCATGGAGCAACTTTCCCAGCAAGAAGTGCCATCTGTTTTGAAGCACAACATTTTCCTGATACGCCCAATAAAGGCCATTTCCCTTCTTGTGTTCTACATCCGGGGGAAACTTACAATCAAGTAACCATCTACAAATTCGGTGTAGAAAAATAATTTTATGAAATAACCTAATTAATAAACTTATAATTTTTTCAAAACCATGAATCAACAAAAACAGAACGGTAATATCATCGCTATCATTACAATGTTCTTCCTTTTCGCGATGATTTCCTTCGTTACTAATCTTGCTGCGCCTTTCGGCACAATATGGAAAAACCAATATGCAGGTGCCAATACCTTGGGTATGATGGGAAATATGATGAATTTCCTCGCATATCTGTTTATGGGGATTCCTTCAGGTAATATGCTTGTAAAAATCGGATATAAAAAAACAGCCCTCATTGCCATGGCAGTAGGTTTCATCGGTTTGTTTATCCAATATATTTCCAGTTTGTTCGGTGCAGATATAGACGTATTCAATTTAGGAGAATATGCCATTAAAATGAATTTTATCATCTACCTGCTTGGTGCTTTCGTCTGTGGTTTTTGTGTATGTATGCTGAACACAGTAGTTAACCCGATGCTAAATCTTTTAGGTGGTGGTGGTAACAAAGGTAACCAATTAATCCAAGCCGGTGGTGCTCTAAACTCATTGTCAGGTACTTTGACTCCGCTTTTCGTAGGTGCCTTGATTGGTTCTGTTACCCCTCAAACAGCTATGTCAGATGTAGCTCCTCTGCTTTTCATCGCAATGGGTGTATTCGTATCAGCGTTTATCGCTCTTTCATTCATCGCCATTCCAGAGCCTCATCTAAGAAAAGCAGGTCATGAAAAAGAGAAATTCTCTCATAGTCCTTGGAATTTCCGCCATACTGTATTAGGTGTAATCGGTATCTTTGTGTATGTAGGTATTGAAATCGGTATTCCAGGCACATTAAATTTCTATCTTGCCGACCCAACGGAAAAAGGTGCGGGTCTGCTTGCCAACGGTGCCGCTATCGGTGGTGCTATTGCTGCCATCTATTGGTTGCTCATGTTAGTGGGACGTTCTGCAAGTAGTGTCATCAGCGGTAAAGTAGCTACACGCACACAATTGATTGTTGTTTCCGCAACAGCTATCTGTTTTATATTAATCGCAATCTTCACTCCAAAAGAAATCACTGTCTCTATGCCGGGATATAGTGTAGAAAATGGATTCGAAATGGCCTCTGTACCTGTCAGTGCCCTATTTTTGGTACTTTGTGGTTTATGTACGTCCATTATGTGGGGAGGTATCTTCAACCTCGCTGTAGAAGGTTTAGGCAAATATACCGCACAAGCTTCAGGTATTTTTATGATGATGGTTGTCGGTGGCGGTATTTTCCCATTATTGCAGCAATTCATTTCTGACGCTGTGGGATATATGGCCAGCTATTGGTTAATTATCGCTTTGCTTGCTTATCTGTTGTTCTATGGTTTGGTAGGATGCAAGAACGTAAACAAAGACATTCCTGTAGAATAATTATAAAAACATATAGTATTAACTTTAAACTATTAATATCATGGATATAGAATACGTAAGAAGTCGCTTCATCAAACATTTTGATGGCACAACAGGTTCAGTATATGCATCACCCGGACGTATTAACCTTATTGGAGAACATACCGACTATAACGGTGGTTTTGTCTTTCCCGGAGCAGTAGATAAAGGTATGATTGCTGAAATCAAACCTAATGGTACTGATAAGGTACGTGCTTATTCTATTGATCTAAAAGACTATGTAGAATTCGGCTTGAACGAAGAAGATGCCCCTAAAGCCAGTTGGGCAAGATATATTTTCGGCGTTTGCCGTGAAATGATCAAACGTGGTGTAGATGTGAAAGGTTTTGACACTGCTTTTGCGGGTGACGTACCTTTGGGTGCAGGTATGTCTTCATCTGCTGCATTGGAAAGTACGTATGCTTTCGCTATCAACGAACTTTTCGGTGACAACAAAATAGATAAATTTGAATTAGCCAAGGTAGGTCAGGCAACAGAACATAATTATTGTGGTGTAAATTGCGGTATTATGGATCAATTTGCATCTGTATTCGGAAAAGAAGGTAGTTTGATCCGTTTGGACTGTCGTTCATTGGAATATCAATACTTCCCGTTCAAACCGGAAGGTTACCGATTGGTATTGGTTGACTCGGTAGTCAAACACGAATTGGCTTCTTCTGCTTATAATAAACGTCGCCAAAGCTGCGAAGCTGCTGTAGCCGCCATCCAGAAAAAACATCCTCATGTAGAATTTTTACGTGATTGTACAATGGAAATGTTGCAGGAAGCAAAAGCCGAGATCAGTGAAGAAGACTATATGCGTGCAGAATACGTCATTGAAGAAATCCAACGTGTACTTGATGTTTGCGATGCTTTGGAAAGAGGTGATTACGAAACCGTAGGACAGAAGATGTATGAAACCCACTATGGCATGAGTAAATTGTATGAAGTAAGCTGTGAAGAACTTGACTTCTTGAATGATGTTGCTTTCGACTGCGGTGTCACCGGTTCACGTGTCATGGGTGGAGGTTTCGGTGGATGTACAATCAACCTAGTTAAAAATGAACTATACGAAACATTCATCACCACTGCCAAAGAAAGATTCAAAGAGAAGTTCGGAAGAAGTCCCAAAGTTTACGATGTAGTCATCAGTGACGGTTCTCGCAAGCTGGTATAAAAAAGATCTCAAATTCGCTAACATATGAAAAAACCGCTTTGGATTCAAAGCGGTTTTTTCTTCTTTATGCTATAAAAGTGTAGGAAATACACTTTTATGTTGCACAACATACTCTTTTCATATCCAATGTATTAGTAATAGTGTTACTTTTACACCCAAAATCATATACTCTATTACTAATTAGTACTTTTATATCATGAAAAGCATGAAAAAAACCTTTCTGGGAACCGGTATCGCACTGACCTTGTTAAGTGCTTGCGCTCCCAAACAATCTCAAGAAACACTTACAAAGTCCGGATTAAACCCCACTAATTATGAAACAATAGTGGATGGCGTAAAACCTGTTAAACTGTATACGCTAAAGAATGCAGCCGGAATGGAAGTATGCGTAACTAATTTTGGCGGACGTATTGTATCTATCATGGTCCCCGACAAAAATGGAAATCTAAAAGATGTAGTGCTGGGTTTTGACAGCATTGCTGACTACCAAAATATACCAAGCGACTTCGGTGCTTCTATCGGACGCTATGCCAACCGCATTAATAAAGGAGTCATCGTAATGGATGGAGAAACCATTCAATTACCCCAAAATAATTTTGGTCACTGCCTGCATGGAGGTCCTAAAGGATGGCAATACCAAGTTTATGAAGCAAACCAATTAAACGACAGTACTATGACACTGACTATGAAGTCACCGGATGGAGATGCCAATTTTCCGGGAAATGTAACCGCTACTGTTACTTATGCACTGACAAGAGACAATGCCATCGACATAAATTACGAAGCGACAACTGACAAAAAGACTGTTATCAATATGACCAACCACTCTTATTTCAACTTGAGTGGAAACCCTGCCAATCCGGCCACCGACCATATTCTTTATGTAAATGCAGACAGCATCACTCCCGTTGACAGCACATTCATGACCACTGGAGAAATGATGGCAGTAACAGAAACTCCATTTGATTTCAATACTCCTAAAACCATTGCCCCCGATGTGACTAACTTTGAAAACGAACAAATAAAATTCGGTAACGGATTCGACCATAATTGGGTACTTAACACGAAAGGCGATATCAACCAGCTGGCTGCCAAACTGACCAGCCCTACTAGTGGTATCACTTTGGAAGTATATACTAATGAACCGGGAATACAAGTTTATACAGGCAACTTTTTGGATGGAACCGTAAAAGGGAAAAAGGGAATTACTTATCCGCAACGCGCGTCTGTTTGTCTGGAAACACAGCACTATCCCGACAGCCCCAACAAATCACAATGGCCTTCTGTAATTCTGGAACCGGGACAGACCTATCACAGCCAATGTATCTTTAAATTCGGTGTTGAAAAATAATTGTTAAACTTTAAATATTTAATATCATGAATTGGAATTCACATGAATTCATCTGGCTGGACTGGACAATACTGGCAGTCGGCATTGTAGCTGTGATATGGGCGGTATGGCGCTCTGTACAAAAAGACAAACGCTCGCAACAAGGAGCAAGCAGTGAAGATTATCTATTTGGCAAAGGTGAGCCATGGTACATCATTGGTGCTGCTATCTTTGCAGCCAATATCGGTTCGGAACATCTGGTAGGTTTGGCAGGAACCGGTGCCAAATCCGGAGTAGGTATGGCACACTGGGAAATGCAAGGTTGGATGATTCTTCTTCTAGGATGGCTTTTTGTTCCATTCTACCAACTATTAAACAATAAAATGGGCAAAATCATTACCATGCCCGATTTCCTTAAATACCGTTATACCCCGCGTACCGGTTCATGGCTTTCTATCATCACACTGATAGCCTACATTCTTACTAAAGTGAGTGTAACCGCCTATACCGGAGGTATCTTTTTGGAGTTCTTACTTGGACTTCCTTTTTGGTATGGGGCAATCGGACTTATTGTCCTGACCGGCATCTTCACCGTACTGAGTGGAATGAAAGGAGTAATGACCCTCTCAGCTATTCAAACCCCTATTTTAATCATCGGTTCTTTCTTGGTTCTTTTCCTGGGACTGTCAGCCTTGGGAGACGGTAATATTGCTACAGGATGGACAGAAATGATGGATCATGCGCGTAGCGCCATGAATGTAGGAGCAGACGGACACGCTTATGGTGCCAACCATATGTTTCACTGGACCGAAGCAGACCCGATGTATCAAGATTATCCTGGATTCTGGGTATTTATCGGAGCTTCCATCATCGGTTTCTGGTATTGGTGTACCGACCAGCATATCGTACAGCGTGTACTTGGACAGCGTAAAGGCGAAGATAATGATGTGGTAATGAAGCGTGCCCGCAGAGGTACTATTGCAGCCGGTTATTTTAAAATCCTGCCTGTCTTCATGTTTCTTATTCCGGGGATGGTAGCTGCCGCCTTGGCTGCAAAAGGTGAATTTGATATGTCAAATACAGATGCGGCTTTTGCTGTAATGGTAAAGGATGTTCTGCCTGCCGGTGTAAAAGGTATTGTAACTATCGGATTCATCTGCGCATTGGTTGCTTCACTGGCTGCTTTCTTTAATTCATGCGCCACACTTTTTACAGAAGACTTTTACAAGCCCATGTTTAAAAACAAAAGTGAAGCTACTTATGTTATGGTAGGACGTATCGCCACCGTAGTTGTAGTTATCCTCGGCATGGCATGGATTCCTGTAATGATGAGCCTCGGCAGCCTTTACGACTACCTGCAAGGCATACAGTCCCTCCTTGCACCTGCAATGGTAGCCGTATTTGCACTTGGTATATTCTCCAAGAAAATCACTCCGAAAGCCGGTGAAACAGCCATGATTGTAGGTTTCCTAATTGGTATGCTCCGTTTGCTGACTAATATCCTCACCAATACCGGAAAAGATGTGATGACCGGCTGGTTTTGGGAAAATACAACTTGGTTTTGGCAGACAAACTGGCTTATTTTTGAAATATGGCTACTTGTATTCCTCTTGTTGTTAATGGTTGTTGTATCATGCTTCACTCCGGCTCCAACCGCCAAACAAGTGGAAGCCATCACCTTTACCGGCAGTTACAAGGAACTTATCAGAAAGAGTTGGAACAAATGGGATGTTATTACCTCTTTAGGTGTAGTTCTGCTTTGTGCACTATTCTATGCTTATTTCTGGTAAACCATAAATTAAAGGCTGTATGCTTTGAATTATCTTGAAGAATACAGCCTGTTAATTTTAAACCGACGCTAAACCATGACCACCTATTATAACATAAACCCTAAATTCTATGTATCTGTAGACTGTATCATTTTCGGTTTTGACGAAGGAGAATTAAAACTGCTTCTACTAAAACGAAATTTTGAACCGGCTATGGGAAAATGGTCTTTGATGGGAGGATTCGTACAAGAAGACGAAAGTGTAGACGCTGCCGCCAAACGGGTATTGGCAGAACTGACCGGATTGGAAAATGTATATATGGAACAAGTAGGCACATTTGGCGACTTAGAGCGCGATCCGGGAGAACGAGTCATATCAGTAGCCTATTATGCTTTAGTCAATGTAAATGAATATGACAGGGAACTAGTGCAGCAGCACAATGCCCATTGGACAAAAATAGACGAACTGCCACAGCTCATTTTCGACCATCCGATCATGATTTCCAAAGCACGTGAACTGATGAAGCACAAAGCATCATACAATCCAATTGGTTTTAACCTGCTGCCCGAACTGTTTACCCTGACACAGTTGCAAAATCTATATGAGGCAATCTATGGCGAACCGATGGACAAGCGGAATTTCCGCAAGCGGGTAGCCGAAATGGATTTCATTGAAAAAACAGATTTGATAGACAAATCAGGTTCCCGACGAGGTGCTTATCTTTATAAATTTAATGATAAGGCCTACAGAAAAGATCCGAAATTTAAACTTTAAAATAATGTGCCGATGCAATAATTTGCCAATTGACAAATTAGCAGATTGCCACATTACCCAATTATTCATTATGTTAGAAAAATTAAAAGAAAAAGTATTCCGTGCCAATCTGGATTTGGTGAAACACGGACTAGTTATTTTTACATGGGGAAATGTTTCTGCCATCGATCGTGAAACAGGTCTGGTAGTAATCAAACCCAGTGGCGTATCATACGATGATATGAAAGCTGAAGACATGGTTGTAGTAGATCTGGACGGCAACGTGGTAGAAGGTTCTCTTCGTCCGTCTTCAGATACTCCCACCCATGTAGTTCTATATAAAGCATTCCCCGAAATAGGTGGAGTGGTACATACCCACTCCACCTATGCTACCGCCTGGGCACAAGCCGGAATGGATATCCCCAATATCGGAACGACTCATGCCGATTATTTCCATGACGCCATTCCTTGTACCGCAGATATGACTGAAGAGGAAGTAAAAGGTGCCTACGAACAGGAAACAGGCAATGTGATTGTGAAACGTTTCAAGAACCTGAACCCTGTACATACTCCGGGAGTACTAGTAAAAAATCATGGTCCTTTTGCATGGGGAAAAGATGCCAATGATGCTGTACATAATGCAGTAGTCATGGAACAGGTAGCCAAAATGGCAAGTATCGCTTTTGCCGCCAACCCTCATTTAACGATGAATTCTTTATTAATAGAAAAGCATTTCAGCCGCAAACACGGCCCCAATGCCTATTATGGACAGAAATAAGAAACAAAGAAATTAATAACCCTTTTAAAATATAACATTATGGAAAAAGCATTTGATCAGTATGAAGTATGGTTTGTAACAGGAGCACAGCTTCTGTACGGAGGTGACGCAGTTATAGCAGTAGACGCTCACTCCAATGAAATGGTAAACGGACTGAACGAATCAGGGAAACTTCCTGTAAAAGTAGTATATAAAGGAACAGCCAACTCTTCTAAAGAAGTGGAAGCAGTGTTCAAAGCAGCCAACAACGATGAAAAATGTATCGGTGTCATCACTTGGATGCACACTTTCTCCCCAGCTAAAATGTGGATTCACGGTCTGCAACAGTTAAAGAAACCACTGTTACATCTACACACTCAATTCAATAAGGAAATTCCTTGGGATACCATGGATATGGACTTCATGAATCTGAATCAATCCGCCCATGGTGACCGCGAATTCGGACATATCTGTACCCGTATGCGCATCCGCCGCAAAGTAGTGGTAGGTTACTGGAAAGACGAAGACACCCAGCACAAGATTGCCGTTTGGATGCGTGTTTGTGCAGGTTGGGCAGACTCTCAGGATATGCTGATCATCCGTTTCGGCGATCAGATGAATAATGTAGCTGTAACTGACGGTGATAAAGTGGAAGCAGAACAACGTATGGGGTATCACGTAGATTACTGTCCGGCAAGCGAACTGATGGAATACCATAAAAACATCAAGGATACAGATGTAGAGGCACTTGTAGCAACTTACTTCAACGAATACGACCACGATGCTTCATTAGAAGATAAATCAACCGAAGCTTATCAGAAAGTATGGAACGCTGCAAAAGCCGAATTAGCTCTTCGTGCCATCCTTAAAGCCAAAGGCGCCAAAGGATTCACTACTAATTTTGATGATTTGGGCCAAACAGACGGCAGCTACTTCGATCAGATTCCGGGACTGGCTTCCCAGCGTCTGATGGCTGAAGGCTACGGATTCGGTGCGGAAGGTGACTGGAAATCAGCAGCTCTCTACCGTACCGTATGGGTGATGAACCAAGGACTTTCCAAAGGTTGTTCTTTCCTGGAAGATTACACATTGAACTTCGATGGTGCAAACAGTGCTATCCTGCAATCACATATGCTGGAAGTTTGCCCTCTTATCGCCGCTTCCAAACCACGTCTGGAAGTACACTTCCTAGGCATAGGTATTCGCAAGAGCCAGACAGCCCGTCTTGTATTCACTTCAAAAGTAGGCTCAGGTTGTACCGCCACTGTAGTAGACTTGGGTAACCGTTTCCGTCTGATCGTGAACGACGTAGAATGCATCGAGCCGAAACCGTTGCCCAAATTACCGGTTGCTTCCGCCCTGTGGATTCCGATGCCTAATTTCGAAGTAGGTGCAGGCGCATGGATCCTGGCAGGTGGAACACATCATTCTTGCTTCTCTTATGATCTGACAGCAGAATATTGGGAAGACTATGCTGAGATTGCAGGTATCGAAATGATCCGTATCGACAAAGATACTACCATCAGCAACTTCAAGAAAGAGCTTCGCATGAACGAAGTCTACTATATGCTGAACAAAGCACTTTGCTAATTCATCCATGAAGAGGGGATGTGTCAAGGCTAATAAGATTCTTGGCACATCCCACCTTATTTTATCATCATTATTGTTGTACCTTAAATTATAGGTTTTAATATGAAATCAGATGCAAAATCAACCATCCAAGCAGGAAAAGCTATTCTAGGCATAGAATTCGGATCAACACGAATCAAAGCTGTTTTGATTGACCAGGAAAACAAGCCCATTGCCCAGGGAAGCCACAGCTGGGAAAACCAACTGGTAGACGGACTGTGGACTTACAGTGTGGAAGCTATCTGGCATGGCCTGCAAGACTGCTATGCAGATCTCCGTTCCAACGTAAAAAAGCTATATGACACAGAAATAGAAACCTTGGCGGCAATCGGTGTCAGTGCCATGATGCATGGTTATATGGCATTCAATAAAGAAGAAGAAATCCTTGTACCTTTCCGTACATGGAGAAATACCAATACCGGTCCGGCAGCCGCCGCTTTATCTGAATTATTCGTATATAACATTCCTCTGAGATGGAGCATTTCTCATTTATACCAAGCTATTTTAGACAATGAAGAACACGTAAGTAACATTGACTATCTGACCACCCTTGCAGGTTTCATTCATTGGCAAATTACAGGTCAGAAAGTTCTGGGCATAGGTGATGCATCAGGAATGCTTCCCATAGACCCGGCTACCAAGAATTATTCTGCCGAAATGATAGCCAAGTTCGACAAGTTGGTAGCTCCTAAAGGATACCCTTGGAAACTGACAGATATCCTGCCCAAAGTCTTACCCGCCGGCGAGAATGCAGGGTTCCTTACCCCGGAAGGTGCCAAGAGGCTGGACGTGTCGGGCCACTTGAAAGCAGGTGTACCTGTCTGCCCTCCGGAAGGAGATGCCGGAACCGGCATGGTAGCAACCAACGCTGTCAAGCAACGCACCGGGAATGTATCAGCAGGCACTTCCTCATTTTCCATGATTGTATTGGAAAAAGAGTTGTCCAAGCCATACGAAATGATTGACATGGTTACCACTCCCGACGGAAGCCTTGTAGCTATGGTACATTGCAACAACTGCACCTCCGACCTCAATGCCTGGATCAATCTGTTCAAAGAATACCAAGAACTGCTGGGTATACCCGTAGATATGAATGAATTATATGGAAAACTTTACAATCATGCGCTCGCAGGCGATGCAGATTGCGGTGGTCTTATTTCGTATAATTATATTTCAGGTGAACCCGTGACAGGACTTGCCGACGGAAGGCCATTGTTTGTACGTTCTGCAAATGACAAATTCAACCTCGCCAACTTTATGCGTACCCATTTATACGCTTCAGTCGGAGTTCTTAAGATAGGTAATGACATTCTTTTCAATGAAGAGAAAATCAAAGTAGACAGAATCACAGGACACGGCGGATTATTCAAAACGAAAGGTGTAGGCCAGAGAATACTTGCAGCAGCTATAAACTCCCCTATTTCCGTAATGGAAACTGCCGGTGAAGGTGGCGCATGGGGAATCGCCCTGCTAGGTTCTTACCTTGTCAACAATGAAAAGAACCAATCCCTGGCAGATTTTCTGGAAGACAAAGTATTCGCCGGTGATGCCGGTATTGAAATATCGCCAACAGCCGAAGATGTAGCCGGATTCAACACATATATCGAAAACTATAAGGCAGGACTGCCTGTTGAAGAAGCAGCGACCCGATTTAAGAAGTGAGTCAAACGGGCTTAAAAAAGAGCCTCTTTACATGTTGCGGTTTACACATAAAGAGTTATCTTTGCAGATATTAAATAAAATAGCAAAGATAAACCGACTCACTAATAGCATTCAAATTATAATATTATTTTAATATGAACGAAAAGAAACTTATGAACCGTGCAGCGGACAACATCCGTATTCTGGCTGCTTCGATGGTAGAGAAAGCTAATTCAGGACACCCGGGTGGAGCTATGGGTGGCGCTGATTTTGTAAACGTGCTTTTCTCTGAGTTTTTAGTTTACGATCCTGAAAATCCGCGTTGGGAAGGGCGTGACCGTTTCTTCCTTGATCCAGGCCACATGTCACCGATGCTGTATTCCACTTTGGCACTGACCGGCAAGTTCACCATGGAAGAACTGGCACAGTTCCGCCAATGGGGCAGTCCGACTCCGGGACACCCTGAAGTGGACATCATGCGCGGTATTGAAAATACTTCCGGCCCGTTAGGACAAGGACACACTTTTGCAGTAGGTGCTGCTATCGCTGCCAAATTTCTGAAAGCCCGTCTGGGTCATGTCATGGACCAGACCATCTATGCCTATATATCCGATGGGGGTATTCAAGAAGAGATTTCTCAGGGTGCAGGCCGTCTGGCAGGTCATTTGGGGCTGGACAACTTGATCATGTTTTATGATTCAAACGACATCCAGCTGTCTACCGCTACCGATGCTGTTACCAGCGAAGATGTTGCCAAGAAATACGAAGCATGGCACTGGAAAGTAATTACCATCGACGGTAATGATCCCGATGCAATCCGCACGGCTCTGACAGAAGCGAAAGCCGTAACCGGCCAGCCCACATTAATTATCGGTAAGACCATTATGGGTAAAGGCGCACGCAAAGCGGATGATTCCAGTTATGAACGTAACTGTGCCACCCACGGTGCTCCTTTGGGAGGTGATGCTTACATCAATACAATCAAGAACTTAGGCGGCGATCCAACCAATCCTTTCCAAATCTTCCCTGAAGTAAAAGAGTTGTATGCCAAACGTGCAGAGGAACTGAAAAAAATTGTTGCAGAAAAATATGCGGCTAAAGCTGAATGGACTAAAGCTAACCCCGAACTGGCTGCTAAATTGGAACTATGGTTCTCTGGCAAAGCTCCGAAAGTAAATTGGAATGTTATCGAACAAAAAGCCGGAGATGCTACACGCAGCGCTTCTGCCAAAGTTCTCGGTGTACTGGCTACAGAAGTAGAAAACATGATCGTTTCTTCTGCCGACCTGTCAAATTCAGACAAGACCGACGGTTTCTTGAAGAAAACACATGCATTCACAAAAGACGACTTCACCGGTGCATTTCTGCAGGCAGGTGTTTCCGAATTAACCATGGCTTGCTGCTGCCTGGGTATGGCACTTCACGGAGGTGTGATTGCTGCATGCGCTACCTTCTTCGTATTCTCAGACTACATGAAACCCGCCATACGTATGGCTGCCTTGATGGAACTTCCCGTCAAATTCATCTGGACACACGACGCATTCCGTGTAGGTGAAGACGGTCCTACTCACGAACCGGTAGAACAAGAAGCACAAATCCGCCTGATGGAAAAACTGAAAAACCACAAAGGACACAATTCTATGTTGGTACTCCGTCCGGCAGATGCGGAAGAAACCACTGTGGCATGGAAATTGGCCATGGAAAATACCAGCACCCCCACCGCACTGATCTTCTCCCGCCAGAATATCGCGAATCTGCCTGCAGGAAACGACTATTCACAGGCTGCCAAAGGCGCTTATATTGTTGCAGGCTCCGATGAAAATCCGGATGTAATCCTAGTCGCTTCAGGTTCCGAAGTTTCCACTTTGGAGGCAGGTGCAGAACTTCTCCGCAAGGATGGCATAAAAATACGTATCGTATCCGCTCCTTCTGAGGGATTGTTCCGCAGCCAAAGCAAGGAATACCAAAACAGTATCATTCCCACAGGGGCTAAAGTATTCGGTCTGACTGCCGGTCTTCCTGTAAACCTTGAAGGTTTGGTAGGTGCCAACGGTAAGGTATTCGGTCTGGAATCATTCGGATTCTCCGCTCCTTACAAAGTATTGGATGAAAAGCTGGGCTTTACCGCACAGAACGTGTATAACCAAGTAAAAGAAATGCTGGCATGAAAAAAGTAGGACTGGCATCCGATCATGCAGGATTTGAACTGAAAGAGTTTGTAAAGACATGGTTAACTGAAAAAGGCTATCCATGCAAAGATTTCGGTACATACAGTACAGAAAGCTGTGACTATGCAGATTATGCCCATCCGCTTGCACTGGCTATAGAAGCCGGAGAATGCGGACCCGGAGTGGCAATTTGCGGAAGCGGTGAAGGCATCAGCATGACATTGAACAAACATCAGGGTATCCGTGCGGCACTATGCTGGATGCCCGAGATAGCCCATCTGTCACGTCAGCACAATGACGCCAATGTTCTGGTAATGCCGGGACGATTCATTGACCATGAAATGGCCGAAAAAATATTGGATGAATTCTTTAACAGCGGCTTCGAAGGCGGACGTCACCAAAAGCGCATTGAAAAGATACCTGTAAAGTAAAATTCACGCAATAATAATAAAAGTAAAAAAAGAGAGGCATTATAGCTTCTCTTTTTTTTTATTCCTATCTTTGCTTAGATTAAAATATAAAATAAAAAATATTACTATGAAGAAGATTCTTTTTTTAATGCTCCTATGTCTGCCATTCATCGCTATGGCACAGACAGATCCCAAATATCTGGCGGGAGCGATAACTATGGATGACGGTAAAGTTTCTTTCAAAACAGAGATACAGGCACCGTCTTTAACGAAAGACCAGCTATATGGCACCATGCTGAAATGGGCCACAGAACGTTTCAAGCCCGAAGGCAAGTTCAATGCACGTGTTCTTTACACCAATGAAGATGAAGGAACCATTGCAGCAGGTGGCGAAGAATATCTGGTATTCTCCTCCTCTGCATTGTCATTGGACAGAACCAGAATTTATTATCAGTTGTTTATCACCTGCGAAAACGGAAAATGTGATATCGAAATGACCCGTATCCGTTATTGGTATGATGAAGCTCGTGACGGAGGAGAAAAATACAGTGCAGAGGAATGGATTGTAGACGATATGGCTTTAAACAAATCGAAGACCAAGCTGGCTCCCATCTGCGGCAAATTCAGAAGAGAGACTATTGACTTGAAAGACACACTGTTCAAATCCATCCAAGATACATTGGGCAACAAGGTCTTGAACAACTCACAAATTGCAGTTGCTCCTGCTCCGGGCGTGACAGCTACTCCGATATCAAATGCAACAACAATCGTTACCGCCACTCCGGTAACTCCCCCTGCCCAACCGGCTGTCATCGGTGGTTCTGAGGGTAATACCGAAATAAAAGCAGCCAATAATGCAACTCCCAGCAAAGAACAAAGCATAGATGACCAAATCAAGGCATCCTCACGTATGACAATTACTGCCGGAAACGATGAACAATTCGAAATCGGTAAAGAATGCTGGGGAGGTTTCGGCCAGTTATTCGGCAAAGAAGTAGCATTCTGCGTAATCGACCAAGCCAAATCAATGGGCAATATGCTGATGGATCAGAGCGATAATTATAAAATTTCGTTCTACAAGCAAGGTAATAGCGAGCCGTGGTTGATAGTAAACTGCAAGAAACTGATGAAACAGACCGTTACCGGTGAGGAAGCAAAAAAGATGAACCCCAGTAATGACGGTCAGAAGGCATATAATATGTATGTAGGTGAAGTAATAAAATAGTCTTTTCTCCCATATATTTATACCGTGACAGTTTATTCTGATAATACATAAAACTTTTTTTAGGGGGAGATAACCTGACAACTCCCCCTAAAAAACATACAAACGATCTACCATATACTTCCCCAAAAGCACCATGACAAATACCATTCAAACATGTCTCCCCTTTAAGAATAAATAACACCGTTCCTCTATCAACCGTTTCACTTGAAACCATTTCTATAATAATCAAACCATTAGAAGAAATCATTCTTCCATTTTTTCCCTATCTTTCTCTCCTTTTTTTAAATGTTTTTAGCAAGAAAGCCGTTTTTTCTGCTCCAATCTTCCCTTTCATAACAAATAAAGAGTATCTTTGTAAACAACAATGAGACAATCATGCCTTATGACGGAACAATTACAGGACATAAAGACACTTATCGAACAGGGTGATACGGAAAGAGCCATTCATGCGCTAACTAATTTCATCCGAAACGATGCGCACGTCAACGATGAACCCTATTACTTACTGGGTAACGCCTACCGCAAAATGGGAGACTGGCAACAAGCTTTGAACAATTATCTGGAAGCCATCGAGCGTAATCCGGAAAGTCCGGCCGTTTCCGCCCGTGACATGATTATGAATATTCTGAATTTCTATAACAAAGACATGTATAATCAATAATAACTAACCCATGGCAAAGATTAAAGGTGCTATTGTAGTAGACACAGAGCGTTGCAAAGGTTGCAATCTATGTGTAGTGGCATGTCCGCTGCATGTAATCGCGCTCAATGCCAAACAAGTGAATAAAAAAGGATACACATTCGCCCACCAGGTATTAGAAGATACCTGCAATGGTTGCGCATCATGTGCCACAGTCTGTCCGGACGGATGCATCACTGTGTATAAAGTAAAACAACAATAAATGTAACAAATATGGCAGAAGAAGTCGTTTTAATGAAGGGAAATGAAGCCATAGCCCACGCCGCTATCCGTATCGGAGTAGACGGTTACTTTGGCTATCCCATCACTCCCCAATCGGAAATATTGGAAACGCTGGCCGAAGAGAAACCTTGGGAAACTACCGGTATGGTGGTGTTGCAGGCAGAAAGTGAAGTCGCAGCAATCAACATGGTATATGGCGGTGCAGCGAGCGGTAAAATGGTAATGACCTCATCCTCCAGTCCCGGCGTCAGTTTAAAGCAGGAAGGCATCTCGTACATTGCCGGTGCCGAACTCCCCTGCCTGATTGTCAATGTCATGCGCGGAGGTCCCGGATTAGGAACCATCCAACCTAGTCAGGCCGACTATTTCCAAACAGTGAAAGGCGGCGGTCACGGAGACTATCGCCTCATAGCCCTGGCTCCTGCATCAGTACAGGAAATGGCAGATTTCGTAGGTATAGCTTTTGATCTGGCTTTCAAATACCGCAATCCCGCCATTATTCTGGCAGACGGCGTTATCGGACAGATGATGGAAAAAGTAGTATTGCCCGAACAGCGCACACGCCTGACAGATGAAGAAGTCATAGCCCGTTGTCCGTGGGCCACTACCGGCAGAACCCACCACCGTACTCCCAACATCATCACCTCATTGGAACTCGATCCTGCCGAGATGGAAAAACGTAATATCCATCTTCAGAAAAAATATGCAGAAATAGAAGAAAACGAAGTACGTTTCGAAGAACTTCACTGCGAAGATGCCGAATATTTGATCGTAGCTTTCGGTTCTTGTGCCCGCATTGCCCAAAAAGCAATGGAAATGGCTCGGGAAGAAGGCATCAAAGTTGGTTTGCTCCGTCCTATTACCCTATGGCCGTTCCCGTCGAAAGCTATTGCAGCACGCGCCGCACAGGTAAAAGGTATCCTCACTGTAGAATTGAACGCCGGACAAATGGTAGAAGATGTCCGTCTGGCCGTAGAATGCAAAGTGCCTGTAGAACACTTCGGACGTCTGGGTGGTATTGTTCCCGATCCGGATGAAGTAATCACTGCACTGAAAGAGAAACTAATAAAATAAGACCGTATGAATATCGATCTGATCAGAAACATATTGAACATACTTTTCATGGCACTGGCACTAGCGGCTGTCATCACTTACTTCATGGCAAGTGACTTCAAAGTATTCATCTATGTCTGTGCAGCAGCTATTTTTCTCAAGCTGATGGAATTCTTTATGCGGTTCATGTTATAAGCAATAGGAGGAGAAACTATGACAAAAGAAGAAATCATAAAACCCGAAAACCTGGTTTATAAGAAACCGACACTGATGAATGACAATCCGATGCATTACTGCCCCGGATGCAGCCACGGTGTGGTTCACAAGTTAATAGCCGAAGTTATTGAAGAAATGGGCATGGAAGATAAGGCAATCGGTGTGTCACCGGTAGGATGTGCCGTTTTTGCATACAACTATCTAGACATCGATTGGCAAGAAGCCGCCCACGGACGCGCACCAGCCGTAGCTACCGCCATCAAGCGTTTATGGCCCGGACGTCTGGTATTTACCTACCAGGGAGATGGTGACCTGGCATGTATCGGCACTGCCGAAACCATCCATGCTTTAAATCGTGGCGAAAACATTACTATCATCTTTATCAACAACGCCATTTATGGAATGACCGGTGGGCAAATGGCTCCTACCACGCTGGTTGGCATGAAGACAGCCACCTGCCCCTATGGTCGTGATGTAGCCATTCATGGCTATCCGCTGAAAATGACAGAAATTGCCGCCACTTTGGAAGGCACCGCCTACGTTACCCGCCAGGCCGTACATACGGTTCCTGCCATCCGCAAAGCAAAAAAGGCTATCCGCAAGGCATTCGAAAACTCAATGAATGGCAAAGGATCCAATTTGGTGGAAATTGTATCGAC
+>7_1#NODE_12_length_39995_cov_63.3136_ID_23
+TAAATTCTTTTACTATGTTCCTTAAGATTAATAATTGAATTTATAGTTAGGTGAATTTATGAATTTTAATAATAATATATCCATTAAAAAATTAACATTACTTATTTTTGTAATTATGTATATTATATTTTTTCTAATAACAAGTTTAAATTTATATTCGTACTCAAAATACGAATTTAATAAAACAGAAAAACTTATAGAAAATTTCAATGTCAGTCTGAGTCAGCAAGTTGTAGAAAAATTAAATAATATTTCTGATGTATCAAAATATCCATTACTTATTCCTGAAGTGAGAAACTTATATTCTATACTTGCTGCTGATAAACCTTATGATATAAGTGAATATAATTATTTAAAGTACATTTGTGATATGATGCTAATCCAAAACACCTCAATAAATGGTGCTTACATATATGATTTGAGCGGAAGAGGCGTATCAAGTACACGTAATAGTTCTAATGATAAACTTAAAAATCCAAAGTCAGAAAAATGGTTTATAGATTCCTTAAATTCTAATGAATTTACATCAATTTTTCCTAATATAAATGCAAGCGATATATTTGAATTTACTTCGCAAGACTCTAAACAGTTAATAGCATTGGCTAGAAAAATAATAGATATTAAAACAAAGAAAGTAACTGGAGTATTATTAATTACTATTCCAATTGATGAAATTCGCAATTTATTAGTAAAAGATCATCTTCCATTTAATAATCAGATAGTTTCTATCTATGATATTAATGGAAATTTAATTCTAACCACAGGCGAGGAATCCAATGTATTTATTCCTACTTATGACCAGTTACACAATGCAACCACTACTCCTAGCATACAGTATATGGATAGTAATATTGAATATATAGTTTCCTACAATACTATACCTTCAACAAGCTGGATAATTGTAAATTCAATTCCTAAGTCAAATGCATATCATATAGACAACTTATATATTTTTTCGTTTATTATTAACATAACTTTCTTCTTAATTTTATTTATTGTGCTATATATATTTTTTATAAAAAGAATATTTAATCCTTTAAAGTTTTTAATCAAGAATATGGAGAGCAATGTTGAAAATAATTTAAATTATAAAGTATCTTATACTAAAAATGACGAAATTGGAATATTAATGAAATCCTATAATGAAATGAAAAGCAGAATAAGCGATTTAATTAATATTAATTATAAGAGCCAAATTGAACAGAAAGAACTAGAACTTAAGCAACTTCAAAATCAAATTAATCCTCATTTTATATATAATACCTTAGAATCTATTCGCATGATGGCAGAAATAAATGACGATATAGAAACTTCAACCATGTCTGAATATTTTGGCTCTATTACAAGGTACAGTATGAATAGAAAAATAAACACCGTCTTATTAAAGGAAGAAATAAGCATTATTGAAAATTATATTTACCTTCAAAAGATTAGATTCGATCAGCTATTCACAATTGAAAATTTGATTACCTCCGAAATTCTAGACTGCGAAATAATTAAAATGATAATTCAGCCATTAATTGAAAACTCTATCTATCATGGCTTAAGTGAATGTAGCGGTGATGGGAAAATAGTAATTAAAGGTGAACATATAACTGAAAATCTAGTACTAACCATTTCTGACAACGGTATAGGTATGGATCATGTAAAATTAAAAAAATTAAATGATTATATTAATGATAAGAATAATGATTTTAGCGGTACCGCCTTAAGGAATATAAACAAAAGATTAAAGTTGAATTATGGCAATGACTATGGATTAGAAATTCATAGTATTCTCGGAAAAGGAACAACTATGGTGCTAACTATTCCATACATTGTAAAGTGAAACTAAGTCCATGGAGCCCCCTATGGACTTAGCCTTATTTTTCTTATTTACTTATTCCCTATAAACATCTATATTCCTATTTCAGAGTTGAAAATTAAAACCTTTTATATCAATTTTACTATTTACATAACTACTCCTTTATTTCCAAAATATCACTTTACCTCGTTTATTACAAACAATTGCGACATAAAATCTTCACGTTTTCTCGACCAATATTCACTAGCTTTTTCTGTATAATCTTTTGATAATACTATTCCTAAATTCATAAGTTCATCACCGTAGTAATTTCCTTCTCTACCTTCTATTGAATACAGTTTATCCGCGTCAAGTCCCTGTAATTTTATACGATTATATTTTTCATTTGGCCTGCATAAAGCTTGATAGTAGCCCACAATGGCTTGTGACTTATCATCAGACACTACCATCCATGAAGTTTCATTGCTTTCAAAAGGATTTAGCATTCTATAAAAATCACCTTTTTGAATCAACGATTTATTTTTCTTAAAGAATTTAACTTGTTCTTTGACTATTTCCTTTTCCTCATCACTCATAGTATTAACATTAAGCTCATACCCAAAAGTTCCAAAATATGCTACATTGGCTCTTGTGTTAAGCGGAGTAAGTCTTCCTACCTGATGATTTGGTACTGCTGATACATGACTTCCTATTGCGCTTAATGGATAAATCATTGAAGTACCATATTGTATCTTTAATCTTTCTACAGCATCAGTATCATCGCTTGCCCAAGTCTGTGGTGCATAGTATAGCATTCCAGGATCAAATCTAGCCCCGCCGCCTGCGCATGATTCAATTAAAAGCTCTGGGTATTTAGTTATTATCTTTTCAGCCAACTTATATACTCCAAGAATATATCTATGGAATACTTCACCTTGTCTATCTTCTTCCAGCGCTAATGAATACGGTTCTGTTATATATCTGTTCATATCCCACTTAATATAAGAAATTTTAGAATTTCCCATTATGTTATCCATCAAACTAAATACATATTCAACAACTTCATCCCTTGAGAAATCTAGGATGAATTGGTTTCTTCCATGAGACATGTTTCTGTTAGGTGTTTGAATAGCCCATTCTGGATGTTCTTTAAATAATTTAGTATCCTTACATACCATTTCTGGCTCAAACCACAATCCAAATTTAAGTCCTATCTCTTCTACTTTTTCAGATAAACCAGCTATTCCATTTGGAAGTTTCTCTTTGTTTTCGAACCAATCTCCAAGAGAACTTGTATCATCATTTCTTTTTCCGAACCAACCATCATCAAGTACAAACAGCTCTATTCCCAGGTCCTTTGCAGCCCTTACTATAGAAAGTATCTTTTCTTCATCAAAGTCAAAATATGTTGCTTCCCAATTGTTTACAAGAATAGGACGTTCTTTATCTCTCCATTTACCTCTTGCAAGTCTTGTTCTATAAAGTTTGTGGTAAGTTTGACTCATTGCATTTAAACCATCATTAGTGTAGACAATTACACATTCTGGCGTTTGAAATTCTTCTCTTGAATCAAGTTTCCATTTGAACTCATAAGGATTAATACCCATCATAACTCTTGATACTCCATACGAATCAACTTCAACTTGTCCTAAGAAATTTCCACTGTATACTAAACTAAAGCCATACACTTCTCCTACATATTCAGTTGTATTTGGACGTTTTAATATCACAAATGGATTATGAACATGACTACTTGCACCTCTTAAACTGTGAATAGATTGCACACCTTCTGTTAACTTTCTCTTTTTAAGATGACACTCTCTAGCCCAAGCACCTGATGTATGAATCATTTCAAAATCTGAATCTGCTAAATCAACGCTACAGCTCATAGCATTGTCTATATAAAATGCCTCTTCCCCTTCATTAGTTATTTTTGCATTTCTGCATATTGCATCAAGACCTTCGTATATTGTATAACTTAGTATTAGTTTACTATTTAATATCTCATCAAATAATGCAATTTCTAATGTTTGAGCTTCTGAAGCTGCTTCAATATAAGTCGATGGTAATCCATTTAACTTATTCTTTCCTTCAAATATTTTATATCCAACATATTTATAGTTACTAATTCTACTTCCATTTTTACTTATAATCGTATGAGCCGGATATCTGTAGTCTGTAATTCCGTAGCTTGGATATTCCTGCTTTATATGTTCTAATGACGAAGTATGATTTCCCTCAAACATATTGCATGAAGGTTTAAGTTCTCTTTCCATTATATGTTTAAATGACTCTCTATGCCTTAATCGTTTACCATAATAAACATTTTCCATCTGTTCTATGCCATCGATTACTCTAATAATATAACTTATATTATTATTATAAAGATGAAACTCTCTAGTATTTTCATTAAATTTAATTCCCATCTTATCTTTCTCCTTCTTAAGTATTTACAAAATAATACTTTAGTGTTTAGTACACTGTAGATAGTGCTAAAATTCACTTAAACAATCATTTGAAGTTGGTTTACTTTTTTAAATATTCTGAAGAATATATATAGTAATATTCTTCAGAATATTTGTTTTAATTTTAAACTAAATATTTTTTATATAAATAGTTTAATAGCAATTATTTATTAATTTATAATTACCACCTAAACTACAGGATAACTTTTCAAAACTTTAAGCTTTCCTTTTATTTCATAATTTCCAAGTGCTGCAGGTATTAAATAGCTATCTCCCATTTTTATCTTTTCTAAATACCCATTTCCTTCTATTATTCCTTCTCCATCCACACAAGTTAAGATGTCAAATTTATCTTCATCACTGCTATCTTGCAATGTTTCTTCTATAGTTAATTTTTCTATTCCAAAATATTCATTTTTGCATAGTAAACTCTTTTTATAACCATCAAATGCTATTTCTTCTCCTTTAAGATTTTCACATTGAAGTTCAAAGTTTGTCACGTCTAATGCTTTTTCTACATGTATTTCTCTTGGTCTACCGTAATCATATACTCTATAGGTTACATCACTATTTTGTTGTATTTCAGCTATTATAACACCTTCACATATAGCATGAATAAGTCCACTATTTATTAAAAAGCAATCACCTTTTTTTACATCTATCTTATTTAAATATTTTTCAACTTCTCCTGATTTTATTGCCGCTTCAAATTCTTCCTTTGTACATCCTTTAGTACCAACTATCAAACTAGCATCTGGTTTAGCATCTACAACATACCATGCTTCTGTCTTACCATAATCACCTTCATATTTAGCTGCATATTCATCTCCAGGATGAACTTGTACTGAAAGTTTTTCTCTTGAATTAATTAATTTCACTAGTAAAGGTAACTTTTCTAGGCTTACCTTAGCACCAACGATGCTAGTTCCGTATTCTTTTATCAGTTCATCAAATCTGATTCCCTTGAATTCACCATTTGCTACAATTCCTGTTCCATTTGGATGACAAGCTATATCCCAGCTTTCTCCGATTTTTCCCTCTGGAAGGTTATCTCTAAAAGTTTCTAGGTCTCTTCCTCCCCATATTTTTTCGTAGTATAAATTTTCAAATCTTATTGGATACATACTTCCTCCTACTCCCTCACTCGATATATAAAAAACATATCATATATTATTAAAAACCTCACTTTAAATATATATTCTTTTCGGCAACTTGTCTATACTTTTGCAGTTAAAAGCATACTTTATTCATTTAAGATAAAATTTATTAACTTATATGTACTCACATAAACTTATGACTCTTCTCTCGAAACTCCATTCAATTAATACAGCGACTCAGCACACTCTCTCTTAATTACATATTTAGTATTAAATTTCCACTAAGGCATTTATATAAATCACTTTCAATATCCAAAATTTACATACTTCCTTAGACGAAAAAGATGCTGCGATAATGTATAATATTACTGCAACACCTTTAATTTATTTATATATTAATTTATTTATATAACTGTTATAGCTTTAAATTCAAAATTGTCATATCTGTGTCTAGAAAACGAGTACTCGAACGCTCTTCCATTTTCTAAGTATACAACCTTTTCCACTTCTGCTATTGGATCTCCATCCATTAACAATAAATATTCTTTATCAAATTCATCTGCTTTACTTACCCTAACCGTCGAATGAGCACTTTGAATCTTTAATCCTAGCTTTCTCTGTAAAAAATTATATATAGACCCATTAACATCTTCTTTTTTTATTCCCTCTGCAATTGATAACGGCATATAAGTTTTTTCTATTACAATAGGTGCCTCATCTACATACCTTACTCTATGTATGAAGTAGACAAAATCACCGTTATCTATCTTAAATGTACTTGCAATTTTCTCATCGGCATTAATAATCTTAAAATCTAAAACTTTGCTTGTGACCTCATGCCCTAAATTAGTATTAGTTAATCCCGAAAACTGTTTTTTTCGAATAATCTCTTGAATCTCTCCTTCGGTTATGTCCTTTATAAAACTTCCCGATCCCCTTCTCTTTACAACCAATCCTTCTGCAACTAACAAATCTAGAGCTTTCTTCACTGTCATTCTACTAGCATTAAATCTTTCGCATAGTTCTTTTTCAAACGGTAATTGTTCATTAGGCTTGTACTTGCCACTCAATATATATTCTTTAATCTGGGATGCTATTTTCTGATACTTTATCATAACTATTCCTTTCATATCTAATTCTTCTTATTATGCAGACTTATAATTTAATTTTTTAAATATTTAAATATCTCACATGCTCTTGACTTAAAGGGAATTATGTGGTGGTTTTCCATTGCATTTGTTATTATAACTTATTATTCCTTATACAACTTTCTTTATCAGTAATTATTGACCATTTCACTAAAAACCCCCACCATATTCCATATATTTTTTATACAACCTGCACAAATATACTCTACCCTTAATATATAATATATGTCTTTCATGCACTCCTGTCTATACTTTTATTTAGTACTTGTTTATCTCACCAATAAATAAAGAATAGGCTGATTAATACCAACCTATTCTTCGTCATTACTATTTTACTACTATATAAATAAAAATTATTTAAAATTATAATATATCCCCCTATAAAAAGACTTTTATCAAATAATCTATCTTATAGGGGATATTTTAATTGAGATTATAAGCTTTATTAATGATCTTGTTGAGCTGCTAATTCATCAGCATAAGCCATAGCATCTGCTTTCTTAAAAAATGGGAAGTAAATTACAGTAGAAACTATTAAGAATACAAATTGTGCTAAAGCGTAACTAGGTCCACCAAGAATAAATCCTGAAATTACAGTTGGAACTGTCCATGGTACTAATATTGCCCCCATTGGTGTTAGTAAGCCTGATGCAATCGCGAAGTAAAGTAATACTGCATTTATTACTGGACCAAGTATAAATGGTACACCCATGATTGGATTCATTACTACTGGAATACCAAATAATATTGGTTCATTAATATTAAATAAATTTGGAGTAAGCGCTAACTTACCTAATTGCTTAAATTGAGCCGATTTTGCAAGGAATAGTAGTAGTAGTGTAAGTCCCAATGTTTGACCACTACCTGTTAAATTAACAAAACTATCATAGAATTGTTGAGTCACTATATGAGCACCATGAGCAAGGTCTAAAGTCCCCGCTTTTTGTAATTCTGCATTGAATGCAGTATTAGCAGTTAATAATGGGCCTACCATTCCTCCTACTGTAATACCTCCATGAATTCCAAAAAACCATAAGAATGGAACAGCAAATGCAATAAGCATAGCTCCAGGTAATGAATCTGATGCTGCTTGTAATGGTGTTTGAACCACTTTATAAATAATCTCTACAAAAGAAGTTTGGAATCCAAATTTGCATAATGCATAAACAACAGCAGCTCCACTAAATATAACAGTAGCCGGAATTAAAGCTGAGAATGCATTAACAACACCTTGTGGAACACCCTCTGGCATTTTTATTGTAATGTTTCGCTTAATCATTGCGCAATAAACAAATGAAACAATCAAACTAACTACAATTGCAGTAATCATACCTGCTCCACCGGTCCAAGATGTAGGAATAGCACCGCCCACTTGAACTGGAGTCGCGTCTGGTGTCGGCTGATAAGTAACAAAGTTATTAGTAACTATAACAAATACACTTAGAGCAATTACTGATGGTGAAAACGGCTCTACTCCCTCATTCTTGCAGTATGAGTAAGTCATTCCTATAACTCCAACCAATGCCATAATGCCCATTGTTGATCCTTGTACTTTGTATAATGGATCATTCCAACCTGCACCAAAAGTTGAAGTCATAAAATCTGTAAATGCTTTTAATGGAAAAGCTGCAATTAATAAAAATACAGATCCAATAATATTCAATGGTAATGTAAACATCATACCATCTTTTAACGCTTGGACACCTTTAAGATTAACGAATTTCATAATTACTGGAACTATTTTTTCGTTAAGTGTTTGATTAAATGACATAATTATTCCTCCTTTGAATTAAAAATATAATATAAATAATTACAAATATAAATTTGCTATTATTGCCTTATTGAATTTTTATTACTTTAAATGTTTTTAAACTTAATATTATCTAAGTACTATAGCGTCTAGATTCAATATATATGCTTAAAGTACTATTTCTTAATTAAACTTAATGCTAAATCTAATACTTTAGCTCCATTCATCATTCCATAATCAACCATAGGTATCACTTCTACTGGAACTCCTTTTGGTTCACAAAGACTTTTTGCTTTTCCTAAAGTATATCCAACTTGTGGTCCTAAAAGTGCAACATCCATGCTATCTAGATGTCTATCCATTTGTGATTCTGGGAATGCTATAATTTCTGCATCTATCCCCTTAGCCTTAGCTGCTTCCTTCATCTTATTAACTAAAACACTTGTTGACATCCCTGATGCGCAGAATAATTTAATTGTAATCATAATTGTTCCTCCTTAAAATCTTTCTATAAATAAAATAATGTATTAAATACTTAAGTACGTTTACATCAACGCACTAGTAATATGTTGATAAGCAAATAATATATTTATTTATTAAGTAAAGTATTTACAACTTTTCTTAATTCTATAATTTGTTCTATTAAAGTTTTCTCAGATATAGCTGTCATTAAATGATCTTGTGCATGAACAAACAAAACTGATAATTCTATTTTTTCACCTGCGGCTTCTTTCTGAAGCATTTCTGTTTGTGCATCGTGTGCCTTAGCTAAAGCATCATTAGCCAAACCCATCTCTTTTTCAGCTTCTTCATACTTACCTTCATTTGCCATTCCTAGCGCCATATAAGCATGATTTTTACAATCTCCTGCATTAATTATAATATTCATTATTGCCATTTCTAGTTGATCCATTTTTACTCCTCCAATTTGCGTGTTATTTTTTATGCAATTATATAGAGCAATAAATATGCCAAACACTATTAATGATATAAGTTTTTATAATTTTCATCCCCAAACTTATATATATTTATAAAACAAAATGAATGAATATTATATATTATAAGTATATACATTTATTTTAAAAAGATTATATATTTTATTTTCCAAGCACACAATATTTATCAATATATGTAGTGTTTAAGCAAAGCATACAGTGTTTATATAAATATTTATAGTGTTTGAAAAAATAATATCTGGTGTTTCATTTTTTCAAACACTGAACCTTTTATTATAAAACAATATTCGATACTAAACCCTTTATCCATTATCATATATGCATCTATTACTGCTGACTTATTTTTCACTAGCCAACAATCTTCTGATATAGTCTCGTAAATCAATTTACAGAATCGAAAATTAACATATAAAAAGAGAAAGTCAAATGATTCCTTCATCTAAACTTTCTCTTAAAAACATGTTCTAAACTCGCTACTTTAATTTTTATATTTCATTATACCCAAGCACCACTTGCATCTACTGTATAACCGTCAATAACTGTATCACTAGCCATAAATCCATCACTATATAAATAGTACCATTTATCATCTACTTTCTGCCAACCTATTTGCATTTGGCCAAATGAAGCCAATAAGTACCACTTACCATTTACTAGCTGCCAGCCTGTTTGCATTGCACCAGTTTTAGCTAGCAAATACCAATTCCCCTTTACTTGTTGCCAGCCCGTTTGCGCTGTACCAGTTTCATTAGCTAAATACCAAGTACCATTTATTTGTTGCCAACCCGTTTTAGGTTGTCCATTGCTATCGAGCAATTTTACAGTCCCATCAGCACTTGTGTTTAAAATTGCTGTAGTTACACCTGTTGTAACTGAATTTTCAGTTGTTGTGCTCGTTGTTGTAGTTGACCCACTGTTCGATGAACTACTATTTGATGATGTACTTGAACTACTACTTGATGAATTTCTCGCAATAGAAGACGTAGTACTTTCAAATATCTTACCATTATAAGTAACTAATAATTTAATATAATATCCTTTATCACTGCCAATTAACCTATAAGTTTTATCAGTTCCCACTAATGCACCGTTAGTGATACTATCATCTTTATTAAATAACCTATACCAAGCATATGTTACACCTTGAGATGGAACAAACTCTGTAGAATCTGCCTTTAATAATTCAGCAGTTAGAGTTCCACCAACCCTTTCAGTTCCATTAATTGCAACTCTTGAAGGCATTACTACTTCAGCTGTTCCACCTGTTGATCCTCCTGCATTTGTATTTCCTCCTGTTTGTTCTCCACCAGTATTATTGCTACCTGAATTTGAAGAACTTACCCCTTTAATATCATCAAAATACATTACTGAGTTAACAGTATCTGTTCCAATTGTATTGCACCATATTCCCATCTTCTCTATATGAGCTTGGTCAAATGTTCCATTGTTTTTTCCTTTAAATTGGCTAAAAGGTATAGTTAGAAGTTTAGCTTCAGTTGTTGCTGCAAAATCCGGCATCCAAACTTCAAAATCTTCACCGTTTGATGTAAGTTGTATAACGAGTTTTTGACCTTTGCCATCTGGCTTAACCCAAATTTGTAATGCATCGCAACCAGACCAATCCGCATCTAATGATTGTGTAATACCAGTCCATCCGTTTGGAGCAATCTTATAATTAAACGCAAGTCCATAATCGCCACTATTTTTATTATTTGTATCTAACTTTGGTGTAACACTGCAGCCTGATCCAACATTAGTAGACCAAACGCCTTGAAGCAATGCATCTTCTCCTGAATATGATTCAAAATTATCTACCAATTTAGGATCTTTCTCTGCCTCTTTTATATTAAATATAGCTTTTATTGTATCTAATTTATTATCATCTGAATATAAATCAATAGACCCAACAGCTTGTCCTATTTTATCGAGAATAGTTTGTGAAATTGCAGCTGAATATATACCATTTTCATCTTTTGTAGCGTTAAGAGTTTCAATAGCATCTCCTGCTTTATTTTTCAATACAAACTTAACTTGTCCATCATATTCTTTTACGCTTGCTGTTACTATAGTTGGTTCAAGAATACGGCTGCTTGAAACTGGTCCTGTTATGAATCCATAAGAATATGCTGACTCTTTAGTTATTGCAGAACTAGAGTAATCTTCCACTCCATCAGCAAATATTGATTTATCTTCATTATAGTAATTTATAAAGTTATTAATCATTTCATGACCTTTTGTATCACTTACCATATATGGAGCAAAGAAACCATCCGTTTCACCAAAATTCGCCCAAGTCATATAGTACGGCATATCCGAACTTGATATTATATCAGCTACATGCTTAAACCAATCTTTATCGGCATTTCCTGATAGAGCCATAAAACCATTATTTTCATTGTTACGCAATCCTACTTCAGATACTGCTGAGAGTTTACCTTTATTCTTTGCTATATTTTGAACTAGGCTAATAGTGTCTTTGAAACTCGCCATCCATGGATCTGTAGATGCATCTTCAGTAGGATTATCATCATAATAATCAAAAGCCAAGATATCAACAAATTCATCACCTGGATAACGTGATAAGTAATCTTCCTCATTTTCAAACGGCCCATTTGGTGAATATACATATAAGAAATTATGAACTTTATCAGTATCCCTTAAATATTCAACTGTATAACGATACATATTCTTGTACGCTTCCTCGTCACAATATGCTTTACCCCACCAGAACCAGCTTCCATTATTCTCATGGAATGGCCTGAATATCACCGGAACTCCAGCATTCTCTAGTTTATGTGCATAAGTTGCAAGCATATCTAAATACCCAACATATACATCATTCAAATCTCCACCTGGCATAATCCTTGACACTATATTACCAGTTGTTGTTCCTGGAGTATATCCTGAATAATCATAATTTCCGTTTTTATCTTTTCCTTTTTCTTTAACTAATTCAAAATTTGGCATATGAGCTGACAAAGTTATTATACCGCCTTCATTTGACGCCTCTATGCTTAAATCTGCTGCTTTTGAAATCAAATCCTTTCCAGCAGCTTTCTCTTCATCAGTTAATGATAATTCGGATCCCGTTAATGACAGGGCATCAATTCCAACAATCGCAGAAATAGAACTTGTTATATCCTTTGTGTCTGAATTAGTTGGACCATTTCCAGCCTTATGATGTGTATCATTTTGATGTCCATATAAAACATAATCCGATTTACCTACACCAGTTAAATATGAGTATAAATTTGCTGTTTTTGATGTTGCACTCGAGTCAACTAACTTTACTTTTGAAGGCATTAAATCGCTTACATCAATTATATTTTGTGTTGTAGTAGTTGTTGTCTTTTCAACATATTTATCTGCTACTTGTTCTTGACTAAGTTTAATATTATCTATATATATATCACCATTATAGTTAGTGCTTGCTCCTATAATTCCAATAGTAATTGAACTGGCATCTACATCCTTAGAAGTAAACTTAAGAGTTACCTGTACTTTCTTTAATCCAGTATTACCAACATCTACCGAATTATTTAAGTCAATTGAGCCATAGGTATTTAAGCTATCTGTAATGAATAATTTTGTTTGAAATCCTCCAGTAGTCATCTTACTTGGGTTATAAATAAAATCATATGTTAATATATTATATCCTTTAAATGAAGTTGCTGCACCCAAATCTTTGTTAATTTTAAATTCACTCCAGCCACTTGCAGAATCCTTAGAATAATCAAGGGAAAGCTTCAAAGCCCCACTGCCAATCGTAGTGTTATCATAATTTACAACGTTATCAGAAGATCCATGATAATCATAGGCTCCTCCATAAAACCATCCATCACTATCATTCTCAGAATTATCAAAATTCCATTTTAAATCAGAAACACTCGGAAGTGGTGCCGTATCACCTGAAGCTTGGTTGTTTACAATTTTAATGTTATCTATAAATAGCTTACCATTGTAATTGCATTGATTTCCTACAATTTTAATATAGAAATTCGATAATCCCACAGTATCTTTGTCAGTTTTTATAGATACAGTTTTTCTTATATAACCATTAACAGCGCTTTCATTTTTGAAACCAGTTGAATCTACCGATCCCGAACCAATACCTGCATCCTTCCAATTGGAGTCTTGCAATGTGCTTTCCAAGTGAATCTCGCCAGTAAAATTAGCATTTGTTTGTGGAATTATAATATCAAATTGAATCTCAGAACCTGCTTTAATTTTTTCTGAGCTTTTAGCAATAAAATCAAGACAAGTTTCAGAATTCCATGTACTTACTCCGTCATAATTTGCATTAAATCCTAACGCATTATTTCCATTTATATCTTCTATTGCTACACTTGATATATCTGCCTTCCAATTAACTTGATCCGGCAACTTCCCATCTTCAAAACCATTATAATAAACAGCAGAAGGGGTTGTACTAATTTCAGACAGCGCTGCGACTGTGTTAGTCTCATTAGTAGCTGCGGTAACTGCTGCACTACTTGTACTGCTATTTAAATTTGTTGCATCGTTACTCCCCCCCTCCATAGTAACTGTTGTACTAGAGATGCCTGTACTATTTTCTAAAACTGTTGCATTATTATTTTCCGCTATTCCTATTGCTGAAACCGGTAAGATAGTAGTTGAAGTTGAGATTACCATAACTGTCGCTAATAGTTTTTTAATTTTTTTTGTTTTCATTAATTTTCCTCCTAATACCAAGTTATCGTTTAATTAACATTGCAAACTTTTAAAATTCACTTTTCTGATTTAGAGAATTCTTATTAGTTATTTATTTATTTTTTAATTGTAAATCTTTGGTTAAACTTTATCAGTTAAAGCATAATTGATACTATTACTTATTTGATTAATTTGCCTTGTTTATATTTTACTTTAACGATTAATTAAAGCATTTACATTATATAATAATTTAATAAGCTTTTCAATATATGGAAAAATGTTTTTATATATGAAAAAAAACTCTTTATTATACATAAAACTTATCTTGTTAAAAATTCATTACCAGCAAGACAAGCTTTTTCCATAACACATAATTGTTTAATAGTAATAAGAAAATATCTTTCTCTTAACTACTTAAAATGAATTCTTTCTAAAGAAATAACCATGAATAATCAAAAAATTATATTTCTAACTATCCATGGTCCTCATTTATAATAATTTTTAATTGAAATATTTTAGAAAGCTATTTGCATTACTCACCTTATTTAGATAATATTCCCCTTAAATATTGAGTCAACTCTTTCGCTGCTTTCTGATGCGATAGAAATCCAGGATGTTGTCTTGATCCTACTGTTTCTTCTGTTGTATTTGGAAGCTGGAATACAGAAACCTTTTTATCACCAGTCTCTTTAATATATGCATCCACAGCACGATAAATAGACGGAAGCATTGGAATTCCTAACATCCCATATACCCATACTATATTAGCCTTTTTATTATATTTTCTAAGTTTAACTAGAAAGTTATAAGCCGCTTTTTCAAAAGCTTCTAAATCTTCCTCATTAAATGTGCCATCCTCATTTAATCTTTGTTTATGAGTCTCTCCTGTAACTTCATCTCTCCACTCAGGTGAAGTAAAAGCTCCTTCATCATTTGTTCCAAGGTTAACTACTACAACATCTGGCTGCCAAGATTCAAAGTGGTTATCTTCGAAAGCTCCTAGAGATTCATTTTTATCACCAGTAAGAAGTCCGCACACCTTTTCATAATACTCTGGAATATTATAATGAGGATTATTATCCCAACTTGTAAGTATCCCCCATCCACTTTGAGAAATAATTCTATGTTCTGCATTTAAGGCTTCTGCAGTCATTGTGCTATAATTATCTATCGCACTAAACCACATAGAAATCCAATCTTCTTCTTTCTTAGCCCCTATTACTCCTTCTCCTGATGTAATACTATCTCCAATAAATTCAATCTTGTACGTTTTTTCTTCTATAGGTAGACATTCCCCATCAAATTTCACAGCATGTATTTGCATATAACTTCCTGGGTCGCCATTCATAGCCTGAACATCTCTTATAATTTTAACATTTTTTATTTCATGCTCTGTCATCCCTCTAAATATACAAACCCAGTACCTTCCGGCAATTAACATTTGTCTGCTTACAGTAGCGGAATTAACAACTATACTAATCCAAGGCTCATACATATCATAGTCCACTTCTACTTCAACCCAAAGTTCAGAGCCTTTCGCATTTAGCTCAATACCACTTCCTGTCCAAAATACTGTTAGTGGTGAAAGACATCCAGTCGTTCTCCCATGAACTTTTAAATTTTCAATATCTGATAATGGGTATATTTTTAGTTTTTCATTTTCTCTCATTATTTTCCCTCCCACAAGTTTTCAATATTCAAACTATATTTTTATTTAATCCTCATTCTAATTTAAATTATATTTATTTTTTACTCACTCTCCCTGGCTACTAATCACTTTTTGTTTCTAGTAGGCCCTCTTCATTACTTTTATATTACATCTGTAATTTCTTTAATTTATAGAACTCACCTTTTTTCTCCATCAGTTCATCATAAGTCCCAAACTCTTCTAATCCACCATTTCCTACAACTGCAATCTTATCTGCATTTCTAATTGTAGATAGCCTATGTGCAACTACTAAGGTTGTTCTATCTTTCACTAAGCTTTCAATTGATTCTTGTATCTTTTTTTCCGAAACGCTATCTAAAGCAGATGTTGCTTCATCAAGAACCAATATCTTCGGATTTCTCACAAAAGCTCTTGCAATTGATATTCTCTGACGTTGTCCACCAGAGAGATTACTTCCATGTTCAGTAATTATGGTATCTAATCCATTTGGGAGTGATTCTATTAACTCCTCCAAATTTGCCGCTTTAATTATTTTACTTAACTCTTCATCAGAAATGTTTTTTATTCCATAAAGGATATTTTCCCGAATAGTATCAGAAAATAATATTGCATTTTGTGGTACAACCGCAATCTTGGAACGATAGCTTTGAAGATTAATATTTTTAATATCCTGATTATCAATCAGTACTTGTCCGTCTGTGGCTTGGAAAAATCCTATTACTAGATTTAGAATTGTCGATTTCCCGGCTCCTGAAGTGCCTACAAACGCTACTGTTTCTCCTGGATTTATAGAGAAATTTAGATTTTTTAAAATTGGACCAGTACTATCTTTGTACTGAAATTCCACATCCTTAAATGTAATTTTCCCTTCTACATCCTTAATTTTCTTTTTCTTACGGTTATTTTCTACATCGTCAGAAAGTAATATATCTCCAATCGAATCCACAGATTCCAGTCCTTTTGCAATAGTCGGCAATAGTGTAATAATACCCGAAATCTGTGCTACTATAGACCCAAAATAAGTTTGATATAATACAACTTCACCAATTGTAATGTTTCCTTTTAATGCTATATAACCTGTAAAACCAAGACAAATTATTTGGAACACTTGAAACGAAACCCAGCTTATGGATGAGAAATATGCCTGAATAAGATCTAACTTCAAACCCTTTTTAGCAACATTCACCAACTGACTATCTATTTTCTTTGTTTCTTGCTTTTCTAACGCATGAGCTCTGGTAACAGGAATTAATTCCACCATTTCCATTACACGAACTGAAGTCTCTTCCATCTCTTTCCTATAGTCTGTATTATACCTTTTTATCTTTCCTCCAAAAGCAACTATAATAAGTACTGCTACAGGTATAGTTGCAAGAAAAAACACAAACACTGTTAAACTCTTAAAAATAACAACTCCTAAAGCTGCTACAATATTTAATACAATACCTAATATTGTTATAAAAACTTGAGATGATAGATTCTCAATCTGTTCAACATCACGCATAATCTTTGACTGTAATCTTCCTGATTGCATTTGATTATGATATGCAATAGAAAGCTGCTGAAGTCTTTTTACAAGAGTACTTCTGAGTTCTCTTTCTACACTTCTAATAGTTTTTGCATATAGAACTGTATGTACATAATTTGTTGGTATATTTTGCAGTACCATAACAAGAATTATTATAATATTAATTACAATAATATGAACTGCATTATCACCTTTATCGGTTGCTGCATTGATAATATTCGCGGATACAACTGGCAGAACCCATACAGGAGAACTTTTTAATAGGAAAAATATAATTGAAAGAAATAACTTTAAGTAATGTCCTTTATATATACCAACAAGAGTTTTTAAAGTACTATTTTCATTCTGTTTAAAAATTTTCAAAAGAGCTTCTTCGCCTGGTTCTAACTTGTCATTTGTTTTATCTTCTTCACCTATCACTTTTCCACCACCATATCATAATACTTCTTTATAACTTTTTCTGCTGGTTTTCCATATACATCATAACCTTTATAATTTTCAGCTCTATTTAGAGAATATTGATTGCACGCCCAATCCCACATAGCAAAACCAGATACCCATTCACGTTTAAGCGAAGATTCAAACATAGCCTTGTACCATTCTGCTTGTTCATTTAAATCTATATCACCTTCAAGGCTCCAATCGTTTGGAACTTCTGAAGAACCTTTAGTGGACATACAACCAGCTTCAGCAAAGAAAAATGGCTTATCGAAATTTTTGACTACTTTTTCGATTCGATCTAACTCTTTTTCCCAATCCTTAAGTGGATAATAACCACTTGAAGATATAACATCAACACAATCCCACCATTTTACATTATGCTCTTGATATTTATCAGTATTATAAGATACAGCTCCATGATAAACATCTCTAATATCAGCAATTAGTTTACGCCATTCATTTTCTCTACGCTCCGACATAACCATTTCACAGCCTGCAATAAACATTTCACAACCTGTTTTTTCTGCTATACGAGCATAATGAAGTTGGAAATCCGTGTAAGAAGCAAACCATTCACTCCATTTTGGCTCACAATGAACGTCTTCATCAAAGAAATTTATATGAGCCCTCCAAGTTCCATTTTTACAATTTACAGTCGGCTTAATCGCTATTCTAAGACCAATATGCTTTGCATAATTTATGATATTTTCTAACTCTGTATCTGAAATAGTAGAATTAGAACTATAACAAATCTCTTCTGATTGAGGAGTATCCTGAAGACCATTTGGTACCAATATTATAAAATTAATTCCAACCCTTTCTCTTAAATTATCTAAACTCTTATATGTTTCTTTTTTTAAATAGCTCCCTTTCCTCGCAAAAGGCGCAAAAGTAAACCCTTTAATAAATTTCATAAATCCCATTCCTTTCTTTAAATTAAGCGCCATGAAGAAAATAACAGATCAAAATGTAATGTATATTTTCTCAAAACAAATCAACTCTTTTGCTGTCATTTAACAAAAGATTTATAAAACAAAAGTTCTAATTCTTGTACGAAGGTTTTATATACGCTAGGCAGAATAAGGCAAATCTTGTTTGTAGCAGATTTTATATAAAAAATAACCGACGTAATATGATATTAAATAAACAAAAACATGCTGATCTATTATTTTTTTCATTGCGCCTCCGCTTACATATACTATATCAATTTCATTTTTCATCTGATATAATACAATTGTTTAAAAATAGAACAAATCTATTTTACGGAGGCTATTATGAATTATTTATTTGAAGAAATTAATGTTTTAACCTCACCCTATGAAGCCTTTTTAGCTGGCACTAAACATGGTGGCTTCCCAATAAAGGCTCACTGGCATTATTATATGGAAATTATTTTTATCATTAAAGGATCTTCATTAATAAATTGTAATAATAAGGAATATGTCCTCGAGCCTGGAGATTTAATTTTATTTCATCCACAAGCGGTGCACTCTATTTTTTCAGCTTCAAGCGAACCTTTAAAGTATGGTGTACTTAAATTTGATATAAATAATCTTCATATAAATAGTAACTATACTCCAAAACTTGGCTCAATATTCAAATGCGCTATAGACGATCCTTATGCACCTATATTACTTCCATCAAAATTATTTAAAAATTCACCAGAACGTTTATTTAATAGCTGCATTGAAGAAGTAGTAATTAAAGATTATGGTTATGACATTCGCTTTCAGTCTTTAGTTTCATCTCTACTGATAGAAATTCTTAGAATATGGAGAAAAACTGGATTTGATACGAATAACATCACTTTAATGCCCTATGATACTGATTCGTTACATACAATATTACAATATATAGATGAGCATTCACATGAATCAATAAAAGTAGAAGACCTTGCTGAAAAATGCCATATGAGTTATTCGTATTTTGCAAAAAAATTTCACGAATTGTATGGTCAATCCTGTAAGGACTATATTGAATTTATAAGATTGAGCAAAGTTAAAGATTTATTATTATTTACTAATTTTGATTTAAATTATATTAGTCAAGAGACGGGATTTGCGGACTGCAGTCATTTAATTAGAACGTTCAAAAAAAAGACAGGTATAACACCAAAACAGTTTAGAATGCTGCACATTATAGATAAATAACATGTAACTTATAGTTATGCGTATAACTAGCAAAAAAAGAAAACCCCCTGTTACTAGGCTGCCAGAAAAATTAATTGTTAATTCATTCCAATAAAAGTTGTGTCAACCATGAATGCTCCCGGTGCAAGCTCGTGACAAGCGGCGATAGAACAACTTTTATTGAAGAAATACATACAATTATTTTTTCAACACAACACTTCGTAAAAGGGCACCTTCTCTTTCTAGTATAGTATATATATCAAAGCATAAGTATGATTTTTAACTAGCTTATCTACAGTTTCTATAAATTACTACTTAAGTCTAGTAAATGTTAGAACTTGTATATCTGTAACCCAAAATTCCTACAAGCTAGATTTCAGTTTAGCTAGATCTTCTAAATTTATAACATATTCATCGTTGTAGAATTTCATCAATTCTTCTTTGGTATTCCATTCTAATTCTTTAACAAAGTTATTCCAAGTCATAAACCATAGCCAATGAGTTTCTGTTTCCTTAAGTATTTTAGGATCTGGAATCGGTCCATTTTCACTTAGAGCTACTGGTTTTACACTATTTGGAATAGCTTCTGTATTTAGAAATTCAATTGTTAGTGGGCCATGATTTTCAAGAGGAGCATAATAATCATTACTGTTAATATCTACTACATCATCTCCCGGATACCACTCTACATTGGGCGAGTTCCACACCCAAATTAAATTATTTAATTCATGATAACTTACATATCTATCATACATCAACCTATATAGCTTTATGTAGGCTTGGGGACCTTTATCTCCCCACCAAAACCATCCTCCAGAAGCTTCATGCAACGGTCTCCATAAAATCGGAATATTGTTGTTTTTAAATATCTTTAACTGTTCAGCTATTGTATCAAGATCTCTTATCATATTAATATTTTCTTCAGTACCTTCAACTAGTGCTTTTTCTAAATCAAAGTTAGTATTTTCAGTATAAAAGCTCTTCCCTCTTCCATTCATTGGAGAGAACCAGTGCCAGCATAAAGTTATAATTGCATCTGTATTTTTTCCCCAAAATAGAGCTGTTTCTATAGTCCCCTTATTATTAGCTAACTCATCTATACACTCAAAATTACTATCAGGTGTTTCAGTTGCTAGTGAGTAACTTAGTAAATCAAAGCCGACTATAGCTGGAGTCTTTCCTGTCATTCTCTTTATATATTCAAAATCTGTTCCACTTGCCTTATTGCAATGTTGACCCGATAAAATTCCTTTACCATATATTTTAGAGAATATTTTCATTAATTCTATGCATTCTTTACTTGCATCTTTATTACTTAATACAAAATTGGGGTTATCCAAAATACAATTAGTACCCTCCGTAGCTATTATGCTATCAATATTCAAATATCCAATTTGCTTTGATATTTTAATCTCATTAACTCCACTTTTTAATTTTAAGCTTCCGATTTCCTTGATAGCAAATTCACTAGCTATATCAAATACTACACTTCCATAGCATTCATCGTTAATAAAAATTCTGTGTACAGATTGTTTCTGAAATGCTGATTCAGAGATTTCTTCAGGAACCGATAATTCGGCTTTTGAAGGTAGAGCATACTTAATTCCTAATCTGTAAAATCCATTATGTGATAAATTAATTTCAGCAGTTATATAATCATCATCATTTATTAATGCAATTAAGTATCCTGAACCGCTATATCCTTTAATTATATTATTTGTTTTACCATTTATATGCTTAATCTCTGTAGAATCTATTATTATAAGGTTATTTATCATAGATTTTCTCCCTAATTCATAAATAATTAGTCTTTTAAAATTTCAGCGCTACATCACTGCCTTAAGTGTCCATGACCTAGATGAAAAATCCCCTATAACTCCTATAGTATCAATTCCAGAGTACATTAACTCATCGCCACCTGCCTCAATATCAGTACCTTCAATTATATAAGTATATTCTGGATTTAGTCCCTTAAATCTTATTTTTTTCGGAAATCTATTAGGTACTTCCAAGTCTTTAAAATAGAATGCAACCGCTTCAGTCTTATCTTCTGTAACATAAATCCAAGCAGTTTCATTCCCCTCAAACGGGCTTAGAATTCTATAAAATTCTCCGTATTGAATAATATGACGTATTTCTTTATAGCGAGCTACTTGAGATTTAACAATTTCTTTTTCCTCGTCTGAAAACTTTGTTAAATCAAGTTCGTACCCAAAATTTCCCGACATAGCCACATTACCTCTAGTTTCCAAGCTTGTTGTCCTTCCAACTTGGTGATTAGGACATGCTGATATATGAGATCCCATTGAACTTGCTGGGTATACTAAACTTGTTCCATATTGAATTTTTAATCTTTCTATCGCATCTGTGTCATCACTAGTCCAAGTTTGCGGCATATAATATAGCATTCCTGGATCAAATCTTCCACCTCCAGAGGCACAACTTTCAAATAGCACTTCTGAGAACTTACTTGTTATGGTCTCAAGAATATAATAAAGCCCTAGTACATATCTATGAGATATTTCCATTTGCTTGTTACTAGAAAGTCTGGCTGACCCTAAATCAGATATCCCCCTATTCATATCCCACTTAACATAAGATATAGGCGCACTTTCTAATATATTAGAAAGCATTTTTATAACTTCATCACATACATCCTCTCTACTTAAATCAAGAACAAGTTGAGATCTCTGAGCTCTTGATTGTTTTGGTTCTCTATTTGGTACATGAATACACCAATCCGGATGCGCACGATATAAATCACTATCAGGAGATACCATTTCTGGTTCAAACCACAATCCAAAACGGATCCCTTTATCAGTAATCTTATTTACAAGACTGTCTAACCCATCTGGTAATTTTCTCTTATCTACTACCCAATCACCCAAAGAGCAGTTATCCGAGTCTCTCTTCCCAAACCATCCATCATCTAATACAAAAAGTTCCATTCCAAATTCTTTCCCTGCCATAGCAATTTCTTCAATCTTCTCAGTAGTAAAATCAAAATAGGTAGCCTCCCAATTATTGATAAGTATTGGTCTTTCTTCAAACTGATATTTACCACGACATAATCTTTCACGATATAGTTTATGATATGTTCTCGACATTTCACCTAATCCAGCATCAGAATATACCATAACAACTTCCGGCGTTTCAAAAATATCTCCCGCAGATAATTCCCAATTAAAATCAAATGGATTTATTCCCATCTGTACTCTTGTGCAGCTAAATTGATCTACCTCTACTTCTGCTAAAAAGTTTCCACTATATACTAAGCTAAAACCATATACTTCACCATTATCTTCATTTGCATTCTTTGTTAAAAGAGCTAAGAAAGGATTCTGCTGGTGACTGCTTATACCCTTCTTACTATCTATAGACTGCATCCCCGGTACCAATGCTCTCTTATAAATATGCTTCTCACGACACCACGCACCTGATAATTGTAACAAATCAAAATTAGAATGTTCTAAATCGATGCTAAAACTTAAAGCTTTTCGCAAATTTATCTTCTCTCCATTAGACTTGCTATTTACAAACTTAGCATATCTAGTTATAACATTATAACTATTGTAAATAGTATACGATAAGATAACCGTAAGCCCCGCAATATCATCACTTAATTTTACTTCTAGTGTTTCAGCTTCCTCTTTATTATTAACATAAGTTGCAGGTAAAGACTCCATTTTAGATTTACCAGGTATAATATCATGTTTCACGTATTTTAATTCGCTAGTACTAGCTCCATTCTCAAGAATTGCTTCATAACTCGGCGTCCTAAAATCCCCTGAACCAAATGCCGAAAATTCTTGTGGTACTACATCTAAATTGGTTTCTTCAACACTAGATGAACCAATTAGTTCATAGCTATTAACTCTTTTCCCATAATATCTATGAGCTAAATAGCCCTCATTGGTTATCTGCATCACATAACTAGTTTCGTCATTGCATAAATGTAATGTTTTACTCTTTTCATTAAAACTAATAGGCATAAAATTTCTCCTCAAATATACTCTAATTTCAAATAATTTTGTATAAAATCATTTACATATACTATACCAACTTCACTACTAAGACGATATAACACAACTTACTAAAAATAGAACAAATCTATTTTGAGAATTTACTAAAACTTTAAGTTAATTTTTACACTTTCAATAAGCCATATGTTATTTACGTATAAAAATAAGGTATTACCTCCACTTCCGCAAGTAGCTGTAATACCTTATATTCTTTCTTTATGAAACTAATATTCCTAAAATAGTTATTTCTTTAGCTATATCTTCTTTAACCACATCAATCTCAATTTTATATCTCTTAACTTCATCATTCAATTCTAGTATTTCTGTTGCCGAATAATCCCCCCAACCATCTTTAAAATAAGTATCTAAAAACGCCTTGCTCTTACCATTTACACTTATATTGATTTTCCCCGAGTTTATAGAAATGCTCTTTTTATATAGTAAGATAATGTTTCTCGCCTCTAACTCAAAAACTAGTTTTCCATCTTTATTATCTTCTATAGTATATTTCCACCCATTTTGAAACACTTGAAATCCTTCATCATAATTATCAAATCCTAACATTTCTTTTGGTTGAATATTAGCATTATTAATTATTATTCCATTTATATATCTATCTTCGAACACACAAGGAGTATTTAAAACATTATCTGTTATTTTTATAATCTCTCCATCTTTATAATCATTTTCGTAGATATTATTAATAAAATTTATCAATAGTTTAGATATTATATAATGACCATCATCATTAGGATGAACTTCATCAGTTAGTACATCAGCAAATTTCATTTTGTTTTTCACAACCTCACACTTTAGAGCATCTCTAAAGCTTATCATCGGTAAGTTATATCGCTTTCCTATTTCTATTTGTTGTTCTTGAACATTAAACCCTGTATCCATCGTCATAAATACTTCTACTACTGCCGGTTTATTTTCGCTAGTTAATAATTTTCTAATTAAGCTTTCGTAAGCAACCTTACACGAATAATCTTCATGGTCATTAACTGCGGCATCAACAAAAACTATATCTGGATTTTGACTTATCACCTGCTTTTCTACTCTGTGAACTCCTATTAAAGATCCAGTTGCTCCAACTCCTGCATTTATATACCTAACATTTACCCTATTGAATTTTTCTTTTAACCAAGCATAAGTTAATTCAACATAACATTTTTCCTGAACTGTTGAGTTACATCCCTGAGTTATAGATCCTCCTAAAAATGCTACTATTAAATCTTCTCCCATCTCAGCTTTTCTGATTAACTTTAATATTCTACTTATATCCCCTTTATTAACTAATGAACTTTTAAACATTTCTTCTGTTATTTTAAATCCCATGTGTCATCCTCCTAACAACTTTTTATATAATTAGTTAATTTAATAGTATTTTAACTTAATCGTTTAAATAATAATTGAATAATTTTATTAATATAAGTATAATGATTTTTACAAACATAAACTTGCATTATTTCAGCAAATAATAACACTATTTTGATATTAAATTGAATTTATAATAAAGAGGTATTATTTATGAATAAAAATATTTTTAAAGAAACTATGTATTCTATTGATTCTATGTTCCCTTTATATAGTTCTGATATTAATATTGGGGATAAAACAAACCCGCTTAATTGCCACTGGCATGATGAAATTGAGTTTATTTTAATAACTTACGGAAAAGCCATATTTCAAATAGAAAATTCCTCCTACGAAGTAAACGAAGGCGATATCATCATCATTGGATCTGGCGAACTTCATTCTGCTTACAGCCAAAGTTTTAGTGATTCGTGTATTTGCAAATCATTGACTTTTAATTGTGATATGCTAAGCAGTAAAAGTAGTGACTCGATTCAGATTAAATTTATTAATCCGTTAATAAATAATCAATTGAACTTGCCTCATCATTTAAAATGCATCAACGATAACGAAAGAATGATAAGATCATTTTTATTAGAATTAATGTCTACACTGAGTATTAGAGAAAGCAACTTTGAATTAACAGCTAAATCATATCTATATATGATTTTTTCAAAAATAATGCTTATGGTTACTCATAAGAATGCTAATGAGTTATTAAATGTTAGTAATTCAAATAAGATAGATAACTTTAAACATGTTCTTAACTATATTCATATGAACCACAATAAATCCCTTACAATAAAAGAGCTATCTCTGCAACTTAATATGAGCGAAGGGCATTTCTGTCGTATCTTTAAATCCCTAACTTTTAAAACTCCTATTGATTACATTAACTACTATAGAACGACAAAAGCGCAGGAGTTTCTAATAAATAGCGATAAAAAAATCTTAGAAATCAGCATTGATGTTGGTTTCAATAATCTTAGCTACTTCATAAATATTTTCAAGAAGAACACTGGCTTTACGCCATCTGAATTTAGAAAAAAAATACATCTTCGTGGAGCAGACATTGAAAAATGAGCTACTATATATCTTATATAATATTTTTAAGACATATTGTAATTATTTACACAGTTGTGTTATTATTTATTATATAAGCTAAACGTTAATTCTTAATTTAATCAATCTTTTTTGCTAATACATACTTCCAATGCAAGCTACATCAAAATTTCATAATACTTAAATTTACGTATAATACTGTGAATATATAGGGGGGACAAACAAATGATTAAAAAAATACTGAAACCAGAGAAAATTAAAGTAAAAATCTTCAATTTTAAGCCAACAAATCTCAAATATATTAGCTTAAATTTTGTAAAAGAAAAATTCAAAAATCTATCTATCCGCAAAAAGTTATTTTACTCTTTTATGTTAGTATCATTTATCGGAATAATTTCCGGATTAATAGGTTTGACATTTATACAAAAAACAACCAGTGAATATAATTCTGCTTTAAAAAATTACGGTTTTTCTCAAGGTGACATAGGAAAACTTGGAATAGAAATAGAAAAGTCTAATTCTTTAGTTAGAGATACTTTATTTTTAACTGATGCTAATGAACAAAAGGATGCCAAAAATTCTCTTAATAAATCTTTAGATGAAATCGAAGAATTACTAAATACTGTTACAAAATCTGTTACTTCAAACGAAGAAAAGGAAATATTAAACAGAATAAAGATCAATCTAGCAGCATATAAACAAATCAGAACCACTGTTGTTGTAAAAGGTTTAGCAAACGATAAAGAATCTGGGCTAAAAATCTTCAAATCTGACGGATCCATCTTGATGAATAAAATCAGCTCTGATATTTCACTCTTATTGCAAACTAAAATAGATACATGTAATCTACTTTCTACCAAATTAAATGTTTTAAAATTTGTTAGTATAATAATTGTTATTACAAGCATGATAATTTCTTTAATTCTTGGCATTTTCTTAGGCAAAAATATTATAAAATCGATCAGCAACCCTATTGATCATATGAAAAATGTGGCAAGCGAAATGGCTAATGGTAACCTTGAAGTTTCAATAGATATATCTTCAAATGATGAAATAGGTGAATTAGCTTTATCTTTCTCTCAAATGATTAAAACTCTAAAAAAATATATCACTGAAATATCTACCGTTTTAGGCAGCATTTCTAATAGAAATTTTGATATCCATATTATAGAGGATTACAAAGGAAATTTTATTCAAATAAGGAGTTCACTGGACAATATAGTAGCATCCCTAAGCAATGTATTCTTAGAGATTAAAGATGCAACTATGCAAGTCAATAGCGGAGCTAGTCAAGTAGCTAGCACTTCGCAGATTATATCAGAAGGGGCAACCGAACAAGCTAATTCTATCGAAGAATTATCTGCCTCTATAGAAACGATTTACAACCAAGTTCAAAATACTGTGACTACTGCGGATAATACTAATTTAATTACCATGAACTTAGTTAAAAGTATACAAAATAGCAATTCCCAAATGAATCAAATGCTTTCTGCCATAAATGATATAGAAAGATCTTCTAAATACATCAGCAATATAATTAAGGCAATTAGCGATATAGCAACCAAGACGAATCTTCTTGCTTTAAATGCTGCCATCGAAGCCGCACGAGCTGGTGAGGCCGGTAAAGGTTTTTCCGTAGTAGCCGATGAAGTAAGAAAATTATCTTTCCAAAGTGCAGATGCAGCTAAACAAACATCATTACTTATTACCGATTCTATCAAAGCTGTAAATAAAGGTAGAGATTTAGCCAATAGCACTGCTAAAACCTTATTGGAAGTAGTTAATAGTGCGACTAATGTTACCGAATTAATATCAAATATTACATCAGTCTCTAAGGCCCAGGCCAATTCAATCGATCAAATACATGATAGTATTTTAAAAATATCTGATGTTGTTCAATCAAATTCAGCAATAGCTGAAGAAAGTGCAGCTTCTAGCGAAGAATTGACTGCCCAAGCTGAAACTTTAAATACAATGGTAGATAAATTTAAGCTTAAATCCTAAATAAAAAATAAAACAGCCGATAGCTTTACTGAATGTAAAACTATCGGTTAAATAATATAATAAAACTTATATTCCTTTTTCACTTTTATTCATAAGAATACCGGTGCAAATGGGCTAATTTCTCTTATGAATTTTTCTCTAATTTTCTAACGGTATCTTTTATAACAATTTTTCCACTTATAACTCTTCTTGCCGGCTTATAATCGCTCTTATGCACTTTCTTTATTATAGCACCAACTGCCGTTTCAGCCATTGTCTTCATATCTACTTCAAAAGTTGTGATCCCTAGGTCTGATAGTTCTGTTATTAAATAGTTATCAAATCCAACTACAGAAACATCTTCCGGAACCCTATATCCTTTATCCTGTAATTTCTTAATCAAAATATATGCTACTGAATCACAATTACATGCAAAAGCAGTTGGCATTTTCTCTGGCAACTCAAAATTTATTTCTTTCTTGCCAACTTCTCTATCTGAAATATAACTATTTGAAGAATAATCAATACCATTTTCAAGTAAAGCCTTTGTAAATCCTAAAAAACGATCTTGAATGCTGCTTGTAGCACGTGGATTTCCCACAAACGCAATATCCCTATGACCCATTTCAATTAAGTAATCAGTTAATAAATACATCCCATAATAATTATCCGAAGTTACAGTATCATAGTTACTATTTTTATCGTATGTATCTAACATCACTACAGGAACTTCATTAAGATCATTTAGATATTCTATATAATCTTTTTTCAATTCTCCCATAACTATAATTCCATCTATTTTACTATCTTGTATCATTCTTGGAATTACTTTATTATTCTCATCATCTTTGCTTATAATCTCCATAATCCCATAATATGATTTTTTAGTTAATGCATTTAATACATTTTGATACAACTCCCAATAAAAGGAATGATACATTTCAACAAATCCTTCTGGAATTAGCACCCCTACATTATAGGTATGACCATCTCTTAGAGATCGCGCAATAGAATTTTGACGATATCCCATTTCAGCCGCAACTTTCTTAATTTTTTCCCTTAATTCATCACTAACTCCCTCTTTGTCAGATAGTGCTTTAGAAACTGTAACTTTACTTACATTTAAAGCTTCAGCAATGTCAGCAAGTTTAATAGCTTTTGCCATATTATTCATTCCCTTCTTGTTGTACGTATAACTAACTATCATAGATGCTGCTTGTTTACTAACTATGATAACATACGGAATTATCAAAATATTTCAATGTTGTTGTTAAACTAATCCACTTAATAAATTTTATAACTTTACACATCTGCATTTAATATATTATAGAATGATGGGTATTATTTAATATTTTCATATGATAAAAAAGTTTTTAACTATAATTATTGTCTATAGTCAAAATTTTATCCTATTCTGTTTAAAAAATTTTCTGCTCACATTCAATTCTTTATAAATAAACGGTTAGTTTTCATTGTTCTCTAATATTATACAATAAAAAGCTGTATTTCGCTATTAGTATATACTCCAAAAGAGTTTTAATTTTAGCTAAAATACAGCTTAATAATTTTATTTTTTTATATTCTTACTTCACTTTTTAAAGTTAACGTTTAAGCGGTTTATAAAAAAAATTATAATTTCCCCTCTTGCCCGTCTATCGTTCCAAGTTCATTATGTTCTTTAATAAACTTAACAGTTTCATCAATAGTAGTATACGCCAAACCTACATACGTATCCGCAGCACCATAGTAAATAGCAATTCTTCCTGTTTCAGCATCAGTTAACGCCGCACATGGGAATACTACATTGGCTACAAATCCACGTTCTTCATACCATTCTTCTGGTGTTAACATTATACTTCCAGCCCTATATAACACTTTCGATGGACAATTCTTATCTAATATTGCTGCACTCATAGAGTAAACCAAACCGTTGCATGTTCCAGTTACACCATGATAGAACATTAACCATCCTTCATCTGTTTCAATTGGTGCAGGTCCACATCCAATTTTAATTGACTGCCACCATCCTGATCCACCTTTTTGCATTACTATTCTATGTTCTCCCCAATATTTTAAATCAGGACTTTTGCTTAAGAATACATCCCCAAATGGAGTATGTCCATTATCACTTGGTCTAGATAACATAACATATTTTCCATCAATTTTCTTAGGAAATAAAACTCCATTACGGTTAAATGGCAAGAATGGATTTTCTAGCCTTATAAATGTCTTAAAATCAGTTGTTTTAGCTATTCCAATTGCGGCACCATCAAAATCCCCACACCAAATAATATAATACGCGTCCTCGATTTTTAGTAATCTCGGGTCATATGCATAAAGTGGTTGATAATCACTTCCTTCTTCATCTACAAATTTTATTTTTTCTTTTTCAAACTCCCAATTAATTGCGTCTTTACTATACCCTAAATAAATATGTGGTCTTCCATTTATAGTTTCGCCACGGAACACTCCTATAAATTCATCCCCGTAAGGCATAACTGCACTATTAAATATTCTAGCTACACCCTCTACAGGATTTCTTTTAATAATTGGATTTTCAGTATGTCTCCATATTGGACCATTAAAGTTAGCTGGCTTCTCTTGCCATGGAATATTAGGTAGATTTTCGCCTAAAATTTTACTCATATTAATTCACCTTTCTTAAGAAATAGCCAATCTTATGTATTATTATATAATTCTAAAGAATACACAATTTAAATAGCATTTCTTTCTATATTTATTATTATTTATTAGCTTTGTTATAAATATAATTAACTTATTCTTTTACTGACCCCGATACTAATCCACTATAAATATGCTTTTGTAAAGTAACAAATACAAGAAACGTTGGAATCATAATCAGAACAATACCCGCAGATATTATTTCCCAATGGGCACCAAATGGTCCTTTAAACTTAAATAACGTTGTTGATAACGTTAATAAGTTTGGGCTAGGTGTATATAAAAATGGTGTGTAGAAATCATTATAAACACCAACACCTTTTGTGATCATAACTGTTACTATTGCTGGGGAAAGTAGCGGAAGAATAATTTTATAATAAATTTGAAAATAGTTTGCACCGTCAATAATCGCAGATTCATCTAACGAAACTGAAATATTCTCTAAAAATTGTAGGAATATATATATAGTCATTATATCAGTACCGCAATATAGAATAATCGGAGCTAATCTAGTATTAAATAAACCTAACGCATGTACAATCTGGAATGTTGCAACTTGTGTTGCTATCCCTGGGATCATTACAGCAACTAGGAACATACCATTTACAAATTTACTAAACTTTGTTTTAAATCTGCTAAATATATATGCTGCCATAGATCCAGTAAGTATTGAACCTATTAATGAAAATACTAAAACAAATAATGTATTTTTAAAACCATTTACCATATTACCTTTTTCAAAAACAGCTTTAAAATTATCTAGGTTAAGGAAAGACTTAGGTAATGCTAACGGGCTTGTAGTAGTATATTCAGCACCAGTCTTAAACGCTGTAAAAAATACACTTAATATAGGAATTATAAATACTAGTACAAAAAAGATTAAGATGGCATATTTAATTACTTCATAAACAATCTCTTTTCCACTCATTTTTTTTATTTTCATACTCTTACATTCCTTTCCTTTTCATAACTGCATTTTGTATACTAGTGATAATTATACACATCACCAATAATACCATTGCCATTGCTGAAGCCAGTCCCACTCTATGATTTTGGAATGCATACTGTACTGTTTGAACTATGAAAGTCATACTTCCATTTCCACCATTGGTCATTATATATGGTGTTTCAAACGCTGATAATGCTCCCGTAAGCGATAAAAATAATTGTAAACCTAGAATTGTTGAAATACCTGGTATTATTATATATCTAAGTTGTTGGAATCTATTAGCTCCATCTACTCTTGCCGCTTCTAATACATCTGATGAAATAGATGCCATTGCAGCCGAAAACATTACGATATTATACCCAATATATCTCCATACCGATACAGAAGCTAATGATATATTAACAATACTCGGATCCTGTAACCAATATTTCACGAAACCACCTAAACCAACTGCCTTTAAAACAGTATCTAAAGTACTATTAGGTTGGAAAAAGAATATAAAAACAAAACTAATTGCAACACTATTTATTAGCGATGGGAAGAAATATACACCTTTAAATAAATTTGAAAATTTACACCCAAATGAAACTAAGTATGCAATTGCAATACCTAATGCGATTTGAATAAATGATGCAACAAAATAATATATACTTACAAATAACGGCTCAAAATATTTAGCATCACTCATTATAAGCTTATAATTTTTAAGCCCTACAAATTCCTTAGTCTTAGAAATACCATCCCAGTCAGTAAAACTATATCCAGCCATTGCTATTGCCGGCAAATAAGTAAAGACCCCTAATAGCACTACTGGTACCATTAAAAACAGGACTGAAATTATAATTTTTTGTTTGTTATAAGGCAATGAGGAGAAGCTAATTTTTTTCTTCATATTGCTGGTGCTAGTTGCTGCATTTTTAGTATTTGCTGTGGCATTTTCAGCATTTGTTGTCATAATAACACTCCTTTACTCTTAAATTAAAAAGGCGATATTTTATTTTATTTTATATCGCCTCTTTTCAAATTAATGACTACATTAAAATACTATTTACCAATTGAGTCTACTCCAGTAGCCCAGCTCTTATTTAATGAAGCCATATATTCATCAAAAGTTTGTTTTCCATTTCCTAAACCAATCTCGATTACTGTTTTAACCCATTTACTATCATTAAGGTTAAGTAATGATTCTTTTTGAACTTTATCTAAATCAGTAGCCATTTGTGTAGTACCCATCTTTTGTTGAACTAATGTTGCTCCTGATCCCGCTAAGAAGTCTGGTAATTTTGCACCAACAAGAGAAGAAACCATATCCGAATCGTTTGGATATTTTTCTACGAAGTATTTTACGAATTCTTTTGCAATTTCTTTGTTTTTACTATGAACATTTACACCCATCATATAATCTGGGGCAATTTGCATAACTTGTTTTCCATCATGTGATATAGGTGATGCCATAAATTTAATGTCTTCAGGTGTTTTAGATTTAGCCTTCATTTGACCAACTGCCCATGATCCTAAAGCCATTACACCTATTTTACCATCAGCCACCATTTGCTTTGAAGTCTCCCAATCTGTTGTCATCGGATCTTCTTCAACTAACTTATTAGCAACTGCATCATTTAATAACTTTAATGATGTATAAAGAGGTTGCCCTTGTGCAAATACATTTTTGTCATAAATCATTTTATTTGGGTAGTCTACATCACCTGACGCGTTAACTAATTGCGCCGCAGACCAGTTAGTTAAGGCCCAGTCATCTTTATAGTTTGTATACAACGGAACTGCAGATGTCTTTTCTTTAATGGCTTTTAAATCAGCTATAAATTCCTCTGGTGTTGTTGGAGTTTTTGTAATTCCAGCTTCTTTAAAAACCTTTTCATTATAGAGAAAACCATTAGCGTTAGCACCAGTTGCTAAACCATAAACAGTTCCATCTACATCTGCATTATCAAGGAAATCATATTTACCTTTAAGTTCTTCTCTAGTTCCAATTGGTTCATAATAATCTTTATATTGATTTTTAGTTATGTTAGCAGGCAGCATTAAAACATCACCATAATCTTCTGTTCCCATTCTAGTGTTCATTGTATTTTGATAATCGTTTAACGCTTCAAAATTAACTGTGGTTCCAGGATGTTTTGATTCAAACTCTTCTTTATACTTTTTAAAAGTTTCGTCCATGTCAGTTCTATGTGTTAATACTGTAATAGTTCCACCTGATTTTCCATCACTTTTTTCTGATGTACTAGTACTACTGCTACCACAACCAGTTAGCGATCCAACAGCTACCGCACCAGCTAATAATAATGCTAATTGTTTACGGATTTTCATTTTTCATACCCCTCTTCTTTTTTAAGTTAACGTTTAATCGTTTTTAGTATATATTCAAATTTAATAATTGTCAATATTGTTAACCATAATTATATTACTTTTTAATTAATTTAACTTAAATTTTAATTATTTTTTTAATTTTTAATTAACTGATTTTTATTACTCTCTATCCTCACTATTCCTCTCCTTTTCACTTTTTAATATATATTTTTTTATTCCATTCCAAGCACAAAAACTGCTCAAAAAACTGCAAAAAGAAAATGTGAACAAAAAAAGAACAGGTATAGTGAATGGACAAAATAAAATACTTATTTCTATCAGAGATATGCATAGTATGAATGTTACGAAAGAATATTTCATATACACAACACTTAATAACATTGAATTTTTAACAATTATCCTTAATGGTAAATTTATACCTATACTCATTGGATATATGTATATCAATATAATACAGAAGAATACTCCTATTATGATAATAATTGAAGTTGCTATACTATAAATTAATCCTTCTGTGGCAATACAAAAAGCTAACAACCTTCCTAGAATCACCATAAATGCAATCACAAATAACCAAACAAGAAAGGATTGCTTCCAATTTTTCTTAAAAGCCTCCTTAAAATCATAAAATAAATCTGAAGGTTTATCCTGCACCATTTTAACTGTTACTGATGTCATCGCTCCAATAGCGGGGCCAATAGATATAATAGGAATACAGCAAATTATAAACAGTAAGTTCAATTTAAGCAGCGACGTAAATTCACGCGCAAATATATCCCCAAATAAGGCCAACCCCTCTTTAGGTGGTGCATCTTTGGAAACACCTCGCCCCTCTTTATTGTAATCAAAGAAAAATAATCTCATAATGTACCTCCAAGTTAGGTTCCAACCTTAAAGCATTAAATTTATAATAAAGCTACTTTACCCGTTATAAGTTCTATACAGCCAAAGATTGTCTACCAATTATCCAAGGATGTTCAATATAGAAAAATAGTTGGTAGCACGAACAAAAAATACCACATTAAATTCATCAAGCTAATCTATACACTTAGATTTTATCAACCACTCTATTACTTTTTCCAACTAGATTAATTTCAAATTGTTTTTCCTGTCTCTTTATCAAATAAATGCATCTTATATTCATCAATTGCTATCTTTATCATATCTCCAGGTTCTACTATAGTATCTGCTGATGCGCGAACAGTTAACTTTTTGTTATCGAAATTAACATAAAGATACACCTCCGCTCCCATTAATTCATGAAGGGCTATTTGAGCATATAGTGTACTTTTTTCATGTTCTTCTAAGAAATCATTTTCTATGCTGACATGTTCTGGCCTAATTCCAAGAACAACATTTTTTCCAATATACGCTTCAAAAGTTTCCTCTCCACCTTTACTTTTAGGAATAGGAATACTATAGCTATTGAATTTTACATAGTATTGGTTATCTTTCTTTTCAATAGTTGAATCTATAAAATTCATTTGTGGCGAGCCGATAAATCCAGCAACAAATAGGTTAGCCGGCGAATCATACAACACCATTGGCTTATCTGCTTGTTGTATGTATCCATCTTTCATAACTACAATTCTATCTCCCATTGTCATTGCCTCAATTTGGTCATGAGTAACATATACAAAGGTAACGCCTAATCTCCTATGGAGTTTAGTAATCTCCCCTCTCATTTCAGCACGAAGCTTTGCGTCTAAATTCGAAAGCGGTTCATCTAAAAGAAAAACTGCTGGTTCACGAACCATGGCTCGTCCTAAAGCTACACGCTGTCTTTGACCTCCTGAAAGCTCCTTAGGCTTACGGTTAAGTAAATACTCAATATCTAATATTTTAGCTACTTCTCTAGTTTTCTTATCTATTAATTTCTTATCTTCTTTTCTTAAATTTAGTCCAAATCCAATATTTTTGTATACAGTCATATGAGGATATAATGCATAATTTTGGAATACCATTGAAATATCTCTATCCTTAGGTGAAACCTCATTAACTAAATTATCCCCAATATATAGTTCCCCTCCACTTATATCTTCTAATCCTGCAATCATTCTTAACGTAGTAGATTTACCACATCCTGATGGTCCAACAAGAACAATGAATTCACCATCATTAATTTCTAAGTTTAGATTTTTCACAACGGTTGCATTACCAGGATAAGTTTTTTCTATATTTTTAAGTGAAATACCAGCCATATTACGCCTCCTTATTTACTTGCGTTGTTATTAAAACTATTTTTAGGTTAACGTTAATCTAAGAATAAATATAATATACCATTGTTTTTTAATCCTTACAAGATTTAAAATATTATTTTTTGTAGTTTTTAGCCCTTCAATAATTTTTAATCTTTATTGCTTACTATAGAATTTTCCGCTATCACTCTTAGTAAACGTTCTCTTATAAATAGTTTATTTATTCTATCAATGCACGTCAATGTTATAGTAATAATAGTTTATTTTTCGGTATTTTTGCATATTTCTATGTTAACTTTATAATCTAATTAACTTAATTTTTACAGAACAAAATTATTTAATTTGTTAATAATATTTTTTTACTGTAAGATCTTTATAAGACCTAATGATTAATACATTTTAATTTAAAATTACCTTATCGTTATACTTTTTTTAACTTTTTTCTATTGACTTTCATAGTGATACTAAATTATAATTTGTCTGTAAACGATATATCATAAAAGGGGGAAAAGTTATGATTAAAAAATCTAAATTCAAACTAATGCTATCTTTGTTACTGTTATCTGCATCGATGTTTACTTTCCAAACTCCAGCTAGTGCAGCCGAAGACTCTTCATGGATAAGAGGCACGAACGTACCTGCAATCTGGTATGATAGTCAATCCTATTCTTCTCTTAACAAAATTAATAGCGAAGGATTTAATACTGTTCGTCTTGTTTGGAGCACTAGCGGATCAACTTCTAGATTAAATGATTACCTTACAAAATGTGATAATTTAGGCCTTAAAGCAATAGTTGAACTTCATGATGCAACTGGTGGTACCACTACAGACTCGTTGAATACTTGTGTGAATTATTGGGTTCGTAGTGATGTATTAACAGTAATGAAGAATCACCCTAAGGCTTGGTTAAATATCGCTAATGAATGGGGTCCAGCTAACAGTAGTGTTTGGAGAGATGGTTACAAAAGTTCTATAAGTAAAATACGTACTGCTGGTTATACTGGTACTATTGTAATCGATGCAGGCGGATGGGGACAAGATAGCAGTGATATACTAAACTATGCTCTTGATGTGTACAATTCCAATACTAATAAGAATGTTATATTCAGCATACACATGTATGGATCATGGAATAGCAATTCAGATATAGATTCATTCTTAAGCAGTTGTAAAAGTAAAGGTATTCCAATTATAGTTGGAGAATTTGGTTATAACTATAATAGCGGTAATAATAATCTTGGTTGCAAAGTTGATGTTGCTCATTTATTAAGTTATTGCAAACAAAATAAAATCGGATTTATCGCATGGTCTTGGGCTGGAAATGATTCTGCAAATTCATGGCTAGATATGACTAATTCTTGGGGAAGTTATACTTGGTGGGGACAATATGTAAAAGATAATATGTGGTAATATATTATAATCACATATGTTGCTTTGTCTCGGATATAAAGAGATATTATTCTATAGATATTCCATGAGAAAGGAAATCATATTTTGAGCCAATAGCAATTTTAAACTACAAAAAAGAATTAGTGAGCTAACTAAAAAAATACTTATTTTCTATGAACGTCTCTATGATACAGATATCTTCCATTGAAATTTAAAATAATATTTAAAGAAAAATTACCGAAACGTTAGCAATATAGTTTATCCATTTTGTGAAATTACCTTGCTTCCATGAAAAACAAATATATTTCTTCATTCAAAAATTAATTGCTTAATTATATTATAAAAAATTTAAGTAAAACCTTATAATTTGCAACTATATAAAATTCATAAACATATTTTACAAAAGGAAGTAAAAGTAAGTTAATCAAATCTTATTCTTTTCATTTCCCAAAATATACCTTTCTATTCAACAAAAAAATCAGAACTTTTTCAACAAGTCCTGATTTTTTATTTATATAGGCTTAAATATCTTATAAAACTGTAACTATTTCAAAGATCAACCGTTTTAGTCAATTTGTGCTTAGCATAAATACAATTACAATTTTTCTCTTCTCTTTGTAGACTTTATAAATATCTCTTTTAAGGTTTCTTTGTCATCATATTTTATTGCATCTTTTATTTTATCCAATTCTACTTCAAAATTTTCAATGCTTTTTAATAGATTCTCTTTATTTCCAAGGAAAAGTTCGCTCCAAAGGTCTTCATTTATATTAGCAATTCTTGTTAAATCACGATAGCTATCTCCAATGAAACTTCCTGTTTCTCTTCCTTCAACATCGCTATTTACCAGTGCTACAGCTAATGAGTGCGGAAGCTGACTTGTGTAGCCAATCATTTCATCATGATATTCTGGAGTTATTCTTTTAACTCTTTTAAATCCAATTTTATAAATCAGATCTTCCACCATGTTTAAATTTTCTTCTTTATTTCTAGAAACCGGTGTTAAAATATAATTTGCACCTTTAAAAACTTGGCTACTTGCAAAATCTATTCCTTTTTTCTCCCGTCCTGCCATTGGATGGCCAAAAACAAAATCTATATTCTCCGGTAATATATTTACAATATCTTCGATAAACATTTTTTTAATTCCAGTAGCATCTGTTATTACTGCACCATCTTTAAAATTGCTTTTATTATCTATAATAAATTGCTTAACTAATCTAGGATATAATGAAATAATTATAAAATCTGCACTCTTAATTACTTCTTCTCCGTTTTTAAAACCTTCTCTTATTAATCCAAGTTTTTTAGCTTTTTCTAAAGATTCTTCATTAATATCTATTCCATAAACATCATTATACCCAGCTTCTTTTAAAGCCATAGTAAATGATCCCCCAATTACTCCAAGACCTACAACTACTATTTTCATATCTATAGCTCCCTTATATAGAATTAGATTTGCTTATCTTCAATTTTTGCTACAGCTTTAACTTTACTCATTAGCACATCAAATTGATCTGGAGTAAGTGATTGTTGTCCATCGCTTAGTGCATTTTCAGGATCGTTATGAACTTCTATCATAAGTCCATCAGCCCCAGCTATAATTGCTGCTTTTGCCATTGGTTCTACCAAGTAAGCATAACCTCCTGCATGACTTGGATCAACAATTATAGGTAAATGTGATAATTTCTTAATTACTGGAACTGCTTGCAAATCTAATGTATTTCTTGTAATAGTTTCGAATGTTCTTACTCCTCTTTCACAAAGAATTACATTTTCATTTCCACCTGCCATGATATATTCTGCTGACATAAGCCATTCTTCTATAGTTGCAGATAAACCTCTCTTTAATAGTATTGGTTTATTTGTTTTACCTATTTGCTTTAATAGATCGAAATTTTGCATATTTCTAGCACCAATTTGAATCATATCCACTTCTTCAACAAAAGTATCTACGTAATCAGTAGACATAAGTTCTGTTACTATAGGAAGTCCTGTTTCCTGTTTTGCTGTTTTTAAAAGTTTTAATCCTTCAAGCTCTAAACCTTGAAAGCTATAAGGTGAAGTTCTTGGTTTAAATGCCCCACCTCTTAAAAAGTTGGCTCCTGCTGCTTTTACTCTTTTTGCGATTTCAACAATTTGTTCTTCACTTTCTACAGAACACGGTCCAGCCATTATTCCAAGTCTCCCACCGCCAACTATTGATCCCTCAATATTAACTACTGTATCTTCAGGCTTAAATATCCTGTTTGCTTTCTTAAAAGGTTCTTGAACCTTCATAACCCTATCTACACCTTTTAATACTTGTAATTTTTTAGGATCTAATATTGAAGTATCACCAACAGCTCCTACTATAAAATATGTGTCTCCTTTAGAAAGATGAGC
+>8_1#NODE_18_length_37282_cov_67.8523_ID_35
+ACAATCACAGTGCCTGTAGTCTTGCCTGGCTTAGTTACATCTGGAGTCTTCTCCCAAGTGTACTTAGTGCCGCTTGGCATATCATCCTTGTTCTTAATGCCCTTTTCTGCTGGTGGTACTACACCTGGGGTAGTGTGAACATCTTGACCTTCTGGGGTGTACTTGTCAGCATCAGTTGGAGTTGTAGTCTTAGTGTAAGCAACTACCACATTGGTATTTGGTGTGTTAGCATTTACATTCTTATCAGCTAAAACAACTTTTGCATCTTTGCCATCAACGGTTGAAGTATAGTCAGTTACTTGTGGCACATTGTATTCTGGCCAAGTGCCTTCAGTTGCTCCAGTTGACTTCCAAGTATTGCCATCTTTTACGCCAACAGTCCATGGAGTATCAGCTTCTACATTTTCACCTTCACCGCCACGAACAAAGTGAACAGTTTGAACAATCGTTTCAGTTGTTCCATCAACCTTATTAACAGTAATCGTACGAACAACGTCTTTGTTCATGTCCTTATTATTTGGATCATATGGTGTTGGAGTTACTGTATTACTCTTTTGGTAAGTAATATGAACTGCTTCACCATCTATTCAATTGCGGAAGCTGATTGAATTTCAGTTGCTTTAGTGCCATTTACGTATGAATCGTAACTAGAAATTTGTTCTACTGCTGCAGTTGGATATTCTGCTTCGCCGCCTAAAACGAACTTGTTGTTTTCGATCTTACCAACTTCCCAAGCACCAGTTCCAGTAACTTTTCCAGTTACTAAGTCTTCAACACCGTTTCTACCAAAGTTAACAGTTTGAGTTGCAATTAATTGCTCTGCTTTGCCTGGCTTAGTTTGGTAAATCTTACGGCTAACGCTAGTAAACATGTCCTTGTACTTGTACTTAGGATCAGTTGGATTTACACCTGGAGTTGTTGGAGTAATGTCCTTTGTTTCGTGAACTAAGTTAATAACAACTGCTTCATTCTTAGCAGGAATAACTACATTTTCTGGTAATGTTTGACCTGCAGCTAGCTTGTAACCTGCTGGAATGGTTAAGTTAGTCTTTACATTAACGCCTGGCTTACCACTTACAACAATTGGGTTACCAACATTCTTCTTGTCAACAGTGTCATAGAATTGATAACTTACAGTTACATCTGCAACTGGAGTTTCACTTTGTTGGTAAGTAATGTGAACTGCTTCACCATCTACTGGCTTGCCGTTTTCAACTGCGGAAGCTGACTGAATTTCAGTTGCTTTAGTTCCATTTACATATGAATCGTAACCAGAAATTTGTTCTACTGCTGCAGTTGGATATTCTGCTTCGCCGCCTAAAACGAACTTGTTGTTTTCGATCTTACCAACTTCCCAAGCACCAGTTCCAGTAACTTTTCCAGTTACTAAGTCTTCAACACCGTTTCTACCAAAGTTAACAGTTTGAGTTGCAATTAATTGCTCTGCTTTGCCTGGTTTAGTTTGGTAAATCTTACGGCTAACACTTGTAAACATGTCCTTGTACTTAGGATCAGTTGGATCTACGCCTGGAGTTGTTGGAGTGATGTCCTTTGTTCCGTGAACTAAAGGAACAATGATTGTATTATCTGTTGTTTGATCAACTGGATAAACGAAACTTGGATCAACTTTCCAATTGGTTGGAACTTCACTATCAATATCAGCCTTCAAAGTAGAAGCCTTTAAGCCTTGATTCTTATTGAAGTTAAAGGTTAACTTGTCTTTGCCATTCTTAGTTTGCATTGGAGTATTAGTTTCAGCATCAATGTACTTAACAATTACAGTTGCATTGTAGTCTGAATCATCATGTTGCTGTTTACTTTGAGTTACTGGAACAACTAAAACTGCAGGTTGACTAGTAATATTGCTTTCAGCCGCTGGATAACTATAGCCATCTACAATACTGTAGTTAGCTGGTAAATTACTGTTAATAATATTCTTTAGTTGCTCAGCACTTAAACTTGAACCCTTGGCAATATTACCAATAGTGTAAGCTGCAACTTCTTTGCCATCATATTGGTAAGAAACTTGTTGGTTAAAGCTAGTCTTTTGATCATCTGGCTTACCTGAATTTCCATCTTTTTCAACGTTGATATTAGCCTTAACGTCAAGATAAGTACCATCGTTAAACATAATTCTTACAGTACCTGGAATATAGGCTAAAACTTCTGGTGCATTAGAATTAGTATTTTGACCATTCCAACCTTCTCTACCAAGGCTATTAACGTTAATTAAAGTACGATATTGTTATTGAGTTAAATCTGAGATATTACTATTTTGCTTAAAGTTCAATGTTGAACCTGTAGTAGCACCGTAGAAGTTGAAGTAATTATTTAGCCAATTGTTATATGCATTAACACCTAAACCTAATTTAGAAACAACATCAGCATCGTTAATTTTGAAGTTATAACGCCACTTAGAATTTCCTGGTAAACTTTCGCCTGTAGTAGTCTGCTCTGCTGGATTTACTTGACCGTTAGCTAATTGATACAAAGTATCAGCTGAACCATTAGCAAAATTACTTACATTAGTGTTTGGTGCAGAAACGCCTGGTAAATTAGTAATCCAAGAATAAGTAAATGCACTAGCTGCAAATTTATCGTTCGCATCTTTTTCGTTGACATAGTTCTTACCATCTGTACTTAGCTTATAAGTAGTTATCTTCTTGTAATCACTTGCTGAATTACCAGTACCATTCCAGTCACTGTAGAATTTAATAGTACTAATAGCACTATCATTAACCGATGGAGTGAAATCAACACTAGTCTTATGAACACTGGCTACTGGAGCAGTAAAACTAGTCATCGTTTGATCGCCATAATAAGTATTATGCTCATGATCCATACCAGTTACACTAGCTGGAACATTAACAATCTTGCTTGAGCCATCTTTGAATGTAACAACAACTGGTACATTAAAGGAACCAAGTTGAGCATTTGAATCTACTGTTTCAGTTACTTTACCTGTTGTTTGGTCAACATCCACGGTAACACCAGTTGGAGCTGTGAAAGTTCCAATCCTATAGTTAGAAACTTCATCGTTTGGCATGTCTGCTGGAATTGTTGGGTTAACAGAACCAGTATTTTGTCCTGAATCTGGACGTTCAACATTCAAATGTGGATAAGTAATGTGATATTTTTCAGAATCTTTTTCTTCTGTAGTTACATTAATAGAACTTGCTGGAATATTAATATCTAGATAAGTATTTTGTCCTTGAGCATCTTTATCATTGAAAGTAATTCTAATTACTCCGCCTTGATCTTGAACAGGCTTAGTTTGCCATGCGGTGGACTGAATTTCACTATCTGGAATATTGTTTTGAACTAAAGCCTTAAATTGTGAGCTAGTTAAATCTGAACCAGCCAAAATATCAATTGGCTCAGCTAAAGTCTTAGCACCAGCACCTTTAGCATCAATATCAAATGGGTTAGTCTTGTCAGTCTTTCCATCAATAGTGATATCAATTACGTTATTAGCAATATTCTTACCGGCAGCTGTAGCTATTTCTACAACAGTATTAGGTGTATTTTCCCAATCTGCAGTGTAATTTGTAATAGTTGTTGGCGTAGTAGCAATTTGGTGATTTTGGTCAATACTGTAAGATTGAACAGATGTAATCATGCCACTGGCAGAAATAACTTGTGAATTGTCACTTGTTTCATGTGCGTTAGCATTAGCACGACTAATTGTTACTACAGTTGCATTATCATTATTCCAAATAACAGTTTGAGTACCTTTAGTTACAACAACTGGTACATTAGCATTTTGCTTGCTGCCATCTGCGTATGTAATAGTAACAGGAATGTTGTAAGCGCCCGGTGTAGTGCTAGTTGTAGGAGTTAAAGTAACTCTACCTGTTGAAGGATCAATTTTGCTCCAAGTGGGGGTTGCTTCAGTTCCTGCAAAATGAGTACCGTCTGGAGTAGTAATTACTTCGCCAATCTTATTAGTAAAGGTTGGATCAGTTGTAGCTGTCTTTCCTTGTTCAACACTAACTGGCTTATATGAAGGAGTATATTGGTTATTTGTTTGTAATTCAGAGCCAAATTTTACACCAGAGGCATTCCACCAACTAAAGTGATTAATAAAGCTATTCAAAGCATTGGAAGCTGCAGTTTCAGTTCCTTCAGGCACAACAGAACCATCAGAGAAACTGTTCGAACCCGTCTCAGAAGGATTTGCAGTTAAAATTACTTCGTTAACACCTTTAGCTGGAGTATCAGCATTAACAGAATCAATCATATATTCTGAGCCTGGTTGATTCCAAGCACCATATTGCTTGTGGGAACGAAAGGCATAGGCAAAGTCCCCACCTTGACTAGTATTGTTTAAGTACTTGATGTTCCAAGTTACTGGATCACTAGCACCTGCTGGCACCATGGTTAATGGAGTATTATAGTTGCTATCAGCTGAATTAATCACAATGTGAGTTTGTTGGTTAGCGACATCACCAGCACCATCAGTCTTAATTAAGTAGCCTGGCTTGTTTGCTGCAGTACGTTGTAAGTTAACTAACTTAGCATTAGTGAAGTTAATGTAGTTTTGACTACTTGAACCCCACATAGTTAAAATAGCAGGCCAGCCATTTCTATATGAGCCTTTAGTTAAAGTATAGGTATCTGGTAAGTAACTTGAATATGAGGAATCTTCCAAATCTAAGCTACCACCATTCACATCAAGATGATAAGTTGCACCAAGTCCGTCCTTTGGTCCCATTGCAAGCAATGGTGAATCAGAATCAGTCACTTTAGTTCTAATAATTGAAAGTAAAGCATTTTGACCAACTCTCACCGTGCTATCAGCAGTCTTGCCATCATAATCTAAGCCAATAAGAGCAGCTGATCTCCAACCAGTGGTATTCATCTTGCTAGTTGTAACTTTTAATGAAGAATTCTCTTGTAAATCAAGATCGCTAGCATTCATAATTCCCATTGAGGAACCAGAGCCCAACTCCATCGTTACTTTAGCATTAGGCATTAAGCGAACAACACCTGAGGTTGCATTATCAATAGTTTGATTTCCTGCACCGGCACCATTAGGAATAGTAATTCCAGCCATGTTAGAAGTATTAGCACTGTTGAAATCAACTGTAGTACCATTACTTACTACAACATTGCCTGAAACGTTAATATTGCTCAAGTTATTTGAAGTACTGTTATTAGCAGCTAAAGTCGTTGATCCGTTAAGGAAGTTAACATTATTAGCTTGAATCAAGGCATTCCCAGTTGTATTTGAACTAGTTAAATTGCCTTGCAAATTATTCTTACCCTCGAAGTTAACATTAGTACCTTTATTATTAAGGAGTTGACCTGAGTCTTGACTCGTAGTAACGCCGTTAAAGGTAATTGCATCATTATTAGCAGCAGAATTCTTAAACCAGAATGGGCCATAACCACTAACAGTTTGCAAACTTAGGTCTTTTAAGACTACGTTCCAGCTATGACTAGCAGTGCTTGCTCCTTGATCATAGTGCGTATTGTCACCTAAGCTAATGTAGCGATTGCCCATGTCTAAACCATATTGATTTTGACCATCAATGGTAACTTGACGCGCACTACCATAATTATTAATTGTTTGGTAAGTATTATTACTCAAGTTAGTATTACTAAAGTCAATATTTTGATTTAATTTAATTGTATTTACGTTAGCATCTTGTAATGCATTGATGAATTGAGAATAATCACTAACTGATTGTTCTTGATTATTTGATGTGTTTTGAGCTTGAGTAATTGAGTTTGTCTGAACAGTAGACTTTACTTGCTTAGTTGCAGCTGTTTTTGCTACAGCGTTAGTGTTAGTAGTTTGCTTTACAGACTCATTTTTATTAGTTTGAACCTTATTATCAGAAACTACCTCTTTCTTTTGTACATTAGTCGTTTCTGCAGTTCTATTAGTGTCTAAAGTAATGTTTTGATTATTAGTTTGATTTTTAACTAGGCCTGGGGCTTCTTTGGAAGCTTTTGCAGTATTAGTAACATTTACTTGATTTGGATTTAAGGTATCAGCTTTTACGCTTTTACTACCTGCACCAAGACCGAAAATAGTAAAGCCAATTAAAACTGAAGCAGCTCCCACTGAAAATTTTCTAATTGAGAAACGCTCTTTTTTATTTTCCATCTTCCGAATTTTTTCTTGATAATTATTCTTAGATAACGTTATTGAATCTCCTCCGTCAATTCTACAGACCTTTCAGTGTTAACTATAGTTCTTCTTTTTATAATATTCAAGGATTTAATAACATATATTGTTTAATGCAGAACTATAAATTACGCTCTAAATATCAATAGCAAAAATTAACAGAAAATCAATATGCTATTCAGTTATTTTATGCTTAAAATCCTTGTTATAGCATAGTGTTTATACGTATAAGCATTTTATTATTGAATAGACAATTCAAAATAAAATATTGTATTTTCATTTGCAAAATATTAATTAATATTAGCCAGGGTATAAACGCCTGTTATTTTAAAACAAAAAAATAAAAATAATTAAAAAAGGAGCCGTATACTACACGACTCCCTCTTTAAATCTCTTTATCTACTAATACTATCAGCACGGCCTTTATAATCACCGTTTTCAGTTCCGATAATTAATTCTTCGCCTTCTTTAATAAAATCTGGAACAGTTACAACTAAACCAGTATCCATCGTTGCAGGTTTACCACCGCCAGCAGCAGTTGCACCCTTGATTTCTGGTTGAGTTTCTTTAACAGTCATCTTTACAGTAGATGGTAAGTTAATTCCGATTAATTTACCTTCATCAGTAAACTTAAGATCAACATCAATATTAGGCATCAAGAACTTAGCTTCTGCTGCAAGGTGTTCCTTAGGAATTAGATATTGTTCATAAGTATCAGTATCCATAAAGATAAAGTTAGCGTCATCATCATAAAGGTATTGTGCCTTCTTTAAAGCAACGTTAACTAACTCCACCTTCTCACTTGGACGCATTGTTTTGTGAACAACAGCTCCACTCATCACGTCACGTAAGTCCATTTGCATAACCGTGTTACCTTTACCAGGCTTGTGGTGGTTACTCTTTAGTACTTCAATTAACTTACCATCTTGGCTAAAAATCATACCCTTTTTTAATTCGATTGCTTGCATGTTTTCTCCCTAAAATTTTCTAATATACATATCGCTGATCTCATGATTACCATACTTTTTAATAATCATATCAGCTCTCTTCTTAGTTGGTTCGATATAGTCATGTAAATTCTTCAAGTTAACATCACGCCAGACTCTTTTGGCAAAATTATCTGCTTGTTCAAGCGGGACGTTAGCCCACTTATAAAAGAAATTATCTGGATTATTGCGATTAATCTCGAGCATTAAATGGTAGCGATCAAGATACCATTTCTCTAAGTCTTCTTCGCTTGCATCCAGATAAATTACATAATCAAAAAAGTCACTTGGGGGAGCTTGCCCTTCTGGAGGCACCTCCAGCAGGTTAATTCCCTCAACTACCAAGATATCAGGAACGCTGACATACCCCAATTCATTAGGCACCAGATCAGAAATTTCCTGCGAGTATAGTCTATATGGTACTCTTTCTTTACCAGCTTTAACGCTTGCTAAAAAAGTATAAAAGGCATCCCAGTTAAATGACGATGGGAAGCCCTTTTGATCCATTAAGTTTTTAGCTTTAAGTTCTGCATTCGACATTAAAAAACCATCAGCAGAAACTTGGGCAATTGTTTTATCTGGTTCAAGGCGTTCGAACAAGCGAGTTATTTTCTTTGCAAAAGTAGATTTCCCTACAGCAACAGACCCAGTTACTCCGATGATAAAAGGTATTTTTTGCCATTTTTCGTTATAAAAGGTCTGCTTAGTGCGGTAGATTGCATTTTTTTGGCTCATATTGTACTGAAGATTTTTCATCATGAAAATCTCCGCACTAAATTCATCGCTTGGAGGGATTAGTGTCTGCCACTTTTCAGATGTCAGATGTGTAAATTGCTCTTGCATAAAAAAGCCGCCTTCCTTCTGCCTTGTTCCTAGTATTTTTACATTGTTCAGCCTATCATATATATTGAGAGAAAGAAAAGAAGATATCTATGAAAAAATTAATTCTTTTTGGTGATTCCCTACTTGCAGGCTATATTGATGGACGCGCAACTAATATTGTAACTCAAGGACTGCAAGAAAAATTACCTAAATTTACAATTATTAATAATTCTGTACCTGGGACAACTACTGAAGAGGCAATTGATTTTTATGAGTTACGAATCAAACCTTTTAAGTATGATCTAGTTATTCTGGCCCTAGGCACTAACGACGCCAACATGCAGTTTGGTTTGAGCGCTGGACGATATGCGCATAACTTACAAGTATTGGTCGATTTAATTGGGGCTGATAAAACATTATTAATGGGACCTTCCTATACTAATTGGAAAATTGCTCAAGATCAAGCTTGGCCTAAAACTTTGCAATTTGAATTAGTTGCTCAAGAATGCCATGTTGAAAATAAAATTCCATTCTTAAATTTTGCCAAAGTAATGCGGCAGACTGGTCACCCCAATAAACTATTGCAAAAAGATGGTATTCACCTAAATAAAGCAGGAAATAAGTTATTGATTGAAAGATTAGCAGACCTAGTTGAAGAAAAAGAATTGGTTACTGCATCGTAAAAAAGCATCCCATTGTTGGGATGCTCTTTTGTACTCCGGATATTTTATTCAGTTACTTCTTGCTTTCTTAATTCATTTTGTTCAGCAACTCTAAAGAATGGTAAATAAATAAAAATACCGATAATGATTAAAATCACTTCAAAAATAATATTTCTCCAATCCATTGAACTCATATATGCCTGGAAGAAAAACGGTGTAAATGAAGGATCTACAATATACCCCATTCCAATCCAGTGTAAACTTTCAGCAATATAAGTAAGAATAATATTAATAATTGGAGCAATCAAAAATGGAATACCTAAAATAGGATTAAAACAAATTGGTGTACCAAAAATTACTGGTTCATTAATACTACAAATTCCAGGAATAATTGATAGCTTACCTAATGCACGATATTTTTCTACTTTGCTTCTCATCATTAGAATTACTAAAGCAAGTGAATTACCAGATCCACCTAAAACAGCAATTCTAAACATCTGTAAATTCATTAAATGAGTAGGTGCTAATCCCTTTGCTACTAAAGCAGCATTAGCACCGGTAGCTGCAATACCAGTTGCAAAGACAATTGGAAAAATTACATTACTTCCGTTAACACCAATTAACCATAATAGATTTCCTAAAGTTACGATCAAAATATAACCCCATAAGCTATTAGCCAAAAATGTAGCTGGAGTCAAACACTTCATAATGAAGGTAGTAAAATCAGCATGCGTTAAGTTGACTAAAATTAAATTAGCACCATAGAAAATAAAGATATTTGCTAATAGCGGTACTAAGGAATTAATAAAGTTGGCAACCATTGGGGGAATCGATGCTGGCAACTTTATCTTTAACTTACTCTTTTCAATCCCGCGGTCAATTTCGACAGCTAATAATCCAATGATAATTGCAACAAATAGTCCATTTGTTCCTAAATTATTGAGACTAATCTTATTATTCTTATCAACAGTAGTTGCAACTATTAAAAAGGTAACTAATGAGATCATCCCATCAGTAGCAGGATGAAGCCTACGATATGACTTACTTAATTCATATGCAATACCAAAAGCACAAATCATACCAAAGATTCCCATAGTCATATTGTATGGGATAGTTATTTGAGCATAATGTGCGACAGCCCAATATTTCCAACCAGCAAGCCATTGCATAAAAATATTAGCTGTTCGTGGATTATATCTATCAAGTACAATTGGTGGGTTAACAACAATTAAGAAGAATGAACCAATTACCAAAAATGGCAATCCGAAAAGCATACCATTTGATATAGCTTGTAGATGCTTTTCATTTCCAAGTTTTTGTCCAATAGGCGTTAAAACTTTATCCAATTTAGTAATCAGTGAATCTTTTTTAGCAGCAGTTTCAGCCATTAGAGATCACCTATTTTCCTTACTAAAGATAAATACAACTTAAATTTGATATGGATTGAACTTGAAAGCATTAGGTATAACTTTACTGTCATCCCAATTTTCTCTAATTTTGTGGTATTCGTCCCAATAGTCATTGTCCACTTTTAATTGTGGAGTAACCTTAGAATCGACTTCTAGAAAATGCATACTTCCTCTTCCCATCTTTTTGCCACGAGTGGTGTGCTTGTCTAATGCATAATCTGGAATTTCAGGAACATAACCTAGAGCAAAGTTCTTAATAATGATATTCTTAAGTAAATCAGAAGACCGATCCTTAGTTGATTCACATAAGTAACGAATTGCATGAACAAACATCATGGCACGATCCGGCTCATTGTAACTAAAGTTTTGTCTCATTTGATTTAGACTATTAATCAAAATTGGAGCTTGTGGATTTCCCATTCCTATATCTTCAACTGAAATAGCTTGAAGTCTACGCCATAGTTTTTCTTCCATTTGCGGAGAAGAAATATACATTTCATAAGCAAATTCACATGCTGCTCGTTCTTTGCCTTTTCTGATTGATTTTTGCAATGCAGAGATAACTTCATCAGCTGCTAATCCATTTCTAGTCCTAGTTCTGGCCCATGGATCAGCTAAAAATTCCTTATCTCTATTTTGTGGTACTTCATTTTTCTTAATATCTTTTTCTGACATCGTGAGTCCTTCTTTCAATATATAGGAGAAAACAATGAATATTCAAACTATTAGCGAAAAGTTTCAACTGAATACTGATGAACAAAAAATATTAATTTATATGAATCAACACCGTAATGAAATTAAAAATATCAATATTCGTGAACTCGCTAAACGAACATTTACATCTCCTAGCTTTATCGTTAAGACCTGTAAAAAGATGAAGCTTTCAGGATATTCAGAATTGGTCTTTCTAATTGCAGATGCGCCAAATTTTCCTAATAATACTGAAAACGACTTAAAAGTAGAGTCATACGTAAAGCCTTTTTCCAACTTGATGGATAAGCATAAAGACTCAATGATCATGATATTGGGCAGTGGATACTCTCAAAATATTGCTAATTACATGAGTGAATATCTTAATTTGAATGGCTTTCGTTGTACATCCAATTCGCATCTTGAGATGCTTAGAAAGCATAAGAATACTTTAATAATTATCATCAGCAATTCTGGAGAAACAAAGCGATTAGCTGAACTTTGCATACAAGCTCAGAAAAATAATCGTGATGTTATTTCCTTTACAGGAGATAAGAACTCAACAATTGCAAAACACTCAACGCTTGCAATAAGCTCAGATACTTTTAACCCCACTTCTTTTGACAGCCATTACCCTCAGCTGTTTTTTGGTCTAACACTCATCTATTTTGAATTATTAATGAGTAACTTTTTGTCTAATTAGGTACCTTCTTAAGACAATTCTTATACTACTTTGGTTTTTAACAATTTTGAATACTTTTCCTTGTTTTGAAAACATGTTTCCATTTTAAAAAACATTTTTATTCAGGCATCAAAAAAGGCATCCCTAACGGGATGCTTTTTTTACACACACTACTCTACGTACAAGGCTTGCTTACCTTGCTGATTATAGCTAGCCTCTATTTTCTTTAAACTTACTTTTTTATCTTTAACGCCATAAGGATCATTTACGTAAACAATCCCCTTCTTTTTATTATATCCAGTAACCACACAAGCATGAGAAGAAGGTGTCACATTAACCTTTCCCTGCTTAGTCTGCCATGTCCGCATATCATTTACCCGGTCATATTTTAAAGTCGTAATAATCATTACTGGGTGTCCTTTAGAAACTAACTTCAACACCCTAACAAAATCATTGCCAGTATAATTACGAATTCTCTTAGTATACTTCTTAGCAACATCATAGAGCGGCTCATTATAAACACACCACCCCGCGTTTTCGATACTCATATAACCAACAAAACCGACATGAGGATTTCCGCGATAATCATTGCCAATAAAAGAGGAAACATGCTTAATGTTAGAAGACAATTCTAATTTACTTACATTAATATCATAATAATTTAGGAGCATTGACAGTGACGTAACTTCACAGCCATTTGGCAGGTCCGGTAATTGCCTTTCTAAGGGGACATTCAATTTTTGCTCAGGTCTTAAAGTAAGCCAGTCATATTCATTTTGAATTTTTTCAAAATTAAGGATAATCCCAACTACTCCAGCTGTAATCAGTATTAAAATTCCATATAAAATCTTTCGTCGACGTCGATATCTCTTTGCTCTGCTTATTCTTTTCATGCTGAATATTCTATATCAGAAATGTCAAAACGCAAATTAAGTTGGCAATGTAAGAATTAAATAGATTTCATTTCTTTTGTGCTTTTAGCATAAGAATTAAATTAACTTTATTTATACTCGAAATATGGAACAAGAATTAAGTTAATTTAATTTATATGCTAAAATTAAATTAAGAATTAAATTAGTTAAAATCTTGTATCAACTATTATTAAAATTAGAGGTTAACAATGGTACCACGTGATTCTTACTTAAATATTTTAGATAAACTACGTAATAAACAAATCATTAAAGTCCTAACTGGAGTACGTCGCTGCGGTAAATCTACTATTCTTCAGTTATATCAAGAGCGATTGCTCAAGTCTGGAGTAAATACTAATCAAATTCAAACGATAAATTTTGAAGATTTAGACTTAGTATCAATTAAGACCTACCTAGACCTATATAACTACATCAATGAACATCTCATTCCTAACAAAATGAATTACATCTTTATTGATGAAATCCAAAGCATTCCTAATTTTGAAAAAGCACTCGATAGTCTTTATATAAAAAATAATGTAGATTTATATGTCACAGGATCTAATGCCTTTATGCTTTCTGGCGAATTAGCTACTCTTCTTTCGGGACGCTACATAGAAATCCCTATCTATCCTTTTTCTTTTAAAGAATTTTTACAAACAACTGAACTTTCAAAAGAAGAAGCCTTTTCAACTTACTTAGAACGAGGTGGATTTCCATTTGCTACTGAATTAAACGACAATAATACTTATCTTTCTTACATTCAAGGAATTATCAATACAGTATTAATAAAAGATATCCTAACGAGAGTGAATCGCGGTAATGCAACTTTACTTGAAGCAATTGCTAGTTTCTTAACTGAAGCCAACGGCAGTCTCGTTACTCCTGCTAAAATTGCCAATACTCTAACCTCTAATGGAATCAAGACTAGCAACGCCACAGTAATTTCATACCTCGAAAAATTAGTAAATTCCTATTTATTCTACCAATGCAATCGATATGATATTGCAGGCAAAAAATATCTACAAATTAATAGCAAGTATTACCCCGTTGACCCCGCCCTCAGACGTGCTCTTTTAGGTCAGAAACGTCCAAACATGGGCAGCAGGCTTGAAAATATCGTGTTTATGGAATTAAAGAGACGCGGTTATGAAGTATATGTCGGTAGTCTTAAAAATAAAGAAATTGATTTCGTTGCAATCAAAGACGGTGTTAAGCAATATTATCAAGTTAGTCTCACAGTCCAAGACGATAAGACTTATAATAGGGAAATTGCGCCCTTTCTTGAAATTACTGATAACTATCGGAAAATTCTTCTCACTCAAGACCCCGGTAGCTACAACGACAATGGTATTGAACAAATAAACGTTATCGACTGGCTACTAAAAGAGCAATAAATTTAAATAAACCCACAAAAAATGGAATGCCAAATTTGGCACTCCATTTTTTTATTTATTCACATAAGTCTTCTCGTCTAAATCATCAAACAGTGGGCTCTTCTCGCCTGTATAAATCAAGTCAAGTTTATACATTGCACGTGAAGTAATTGTGTAAAGCAATTGCGTTTCATCAAGTTGGTGATAATTATCCCTTGAAACATTCCAAGCAATTACTGCATCAAATTCAAGGCCTTTAGCTAAATATGATGGCATAACTAAAGTTCCAGGCACTAAACGCTGGTTAGCTGACCCAATTAAAGTTGCCTTAATTTTTCTTTCTTTCAAAACCTTAGCCACTTCTTTTGCTTCAGCCAAAGTCTTAGTAATAATGGCAGTAGTTAACTTTTGCTCATCATTTTCTACTAAGATATCTTCTAAAGCATTATATTCTTTTTCAAGACTGTCACGCTTGTAAAAAGCAGGCTTAGGACCACGTCTATCAAAGGCCTCAATCTTTTCACCTTGCCGCAGAATTTGCTTAGTAAAATTAGTTAATTCCTTAGTTGAACGATAAGACTTGGTTAATTGAACAACATCAGTCTTTTCAGGATCAAACAACTTGGAAATCTGACCTAAAAGAGTCTTACTTTCATCTTTAGTAAAAATAGCCTGGTTCAAATCTCCGAGCATCGTAAATTTAGCTCTTGGGAAGTTGTATTTAAGGTAAGCTAACTGGAATGGAGTGTAATCTTGAATTTCATCAATAAAGGCATAACGCATTTCATAGTCAGTTCTACGCCCTGTAACTAAATCGTACAAGTACAAATATGGTGAAATATCAGCCATCTTGATCTTGCCGTTTCTGAACCTATCTTTAACATTTTCAATATGTGCTTCCCACTCTTCTTGGCTAATCTCCCACTTGCTTAAATCAATCAACTTAGGAACAGCACGCAAGAAGCGCAAGTATTGCGCACGAATATTCAAGAAACGGTTCTGATGAATCTTACGACTAACTTGCTTTAATTGCTTAATTACAATTTTACGAGCTAAGAAGTGCTCTTCTTTAGCACTTGATTCAAATTCTTGGTCTGGACGATCATATAACTTATTCAATTGCTCTTGATCTAACGATTCAATCGTCTTATCAACCCAAGCCTTCTTAGTTTCTGGCTCAATTCTTCTATTTAAGCTATTAATTAAAGCTTCTTTGGTAGCTTCAATTCTGTTTCTTAAATGGTAATTTTCATTAAAACCATAGTAAATTTCCTTGATCTTTTCTTTATCAAAAAATGGTTTCTTCTTATTCTTGAAATAAATATTTTTAAAAATTAAACCATTCTTTTCAAGGTGCTTAGCATAGCGAGTTACCGCATTAAAGAATTGTAAGGAATCTTTTAAGTTAACGATCTTGTCATTTTGCTCATTATCTTCGAATTGTTCAAATAAGTTTTCAACATTCATCCCTGGAACACGACGAGAAACAAATTGCCAGTAAGTCATCTGCACCATATTTTGTTCACCCATTTCAGGTAGAACATTTTTAACATAATCGTTAAACAATTGATTAGGGCTAAACATAATAACATCGCTAGAAGTTAAATTCCCGTGATAACGGTAAAGTAGGTACGCCACACGTTGCATAATAGCTGAGGTCTTACCTGATCCTGCTGCCCCTTGAACAAATAAAAGATCTGCACTAGTATTTCTAATAATCTTATTTTGCTCACGCTGAATCGTTGTTACGATCGACTTCATCTGTGTAGAAGATTTTTCGTTTAAGACATTTAAGAGCATTTGATCCCCAATTGATTCATTGGTATCAAACATATTGGTAATCTTACCATCTTCAATTAAGAATTGCCGTTTCTTAGTCATATCAACGGTTTGCACACCATCGGGCGCATTATAAGAAACTTTACCTAACTTACCATCATAATAAATAGAAGATATCGGTGCACGCCAATCATAGATTAAAAAATGATCTTCTTTATCTGCAAAAGACCCTAAGCCAATATAAATCGTTTCAGGATCTTCATTAGGTTCTTGGAAATCAACTCTGGCAAAGTACGGTCTCTTTTCTAGACGCTGCAAAGTTGATAATTGCTTAGCAGAATGTTGCCAGGCATTTTGACGTTCTGCTGACATTTGTTGCTGCTGATGAATTGACAAGGCAGTATCCATTGAAGTTGAATAGCCATCATAATCTAATTTCACATCATCAAAAAAGTGCGAATTAATATTTTGCGCTTCATTTTGCGCATGTTCAATTGAATGATCTAATTCGCTTTCTTTCTTTTTAATTAAGCCTAGAACTTTATCTAAATGTTTTTGTTCTTTTTGTTGTTCAGTTTCTTTTACCAAAATTAAGTCACCTATTTCTAGTATTAGTAAAAACTTTGCATACTATTTTATCATATGTATACGCTTTCTAAAAGGATTTACAACTTTGAGAAAGTCTCAATTATTATTTAGTCTTTTCTTAATTAATTAGTTTTATAATTAAATAAAATTACCTAGCGAGATGAAAAAGTGAAACGATTCTTTAAAAGTATTCTAGTTCTAGCTCTTTTATTTATTGGACTTAACTTTGCTTATCAAAAGACTGCGCCAGAAATTGAAAAAACTTTTGGAACTAGAAACCCACTCCCATATTTAACAGCCAAAGTACAACAATTTATTTCACCTGAAAAAATTCAAAATGATGATACAAATGCCGACAGTTCCAAAGGACATACTTTTGAAACTAACTCTGCATCTGTTTATCTTGACCTCTCTGATCCCACCCTCAGGCAAGCCGCAATTGATGGAATCAATATTTGGAACAATACAGGGGCCTTTAATTTCAAAATTACGAATAACAAAAATAATGCCAAAATCATCATTAAAGCAATGAATGATGGACAGACTAACGCGGCTGGTTTAACTGATACGCAATATAATTCCCTAACAGGGCACTTAATTAAAGCAACTGTCCGTTTAAATTCATATTACCTTTTAAAATCCAAGTTATGGCTACAACCACGGTCGAATCGTCAACACAGTTGAACACGAATTAGGCCATGCAATCGGGTTAGGCCATAAGAACGGCATTTCCGTCATGTATCCACAAGGATCTTTCTATACCATTCAGCCAAGCGATGTTGAAGATGTTAAAAAATTATATCAAGAACAATAAGAGCGATTCTATTTTTAAGAACCGCTCTTATTTTGTATTTTTCTTTTTTAATTGGTGTTGCTTTTTAAAATAAGGAATCCAGAAAGTTATGACATAACCTACTGCAATACCTACAAAAGTCCATACCATAATATTTTTAACAAATAAACCGATAAACAAACCAATTAAGCCAAAAATCCCAATAATAAATGATTGATCTAGTTGCTTCATACTTATTTCTCCATTTCTATCTTAACTATAACAAAATTATCTTATTATAAGCATATTTTTAGACTTACTTTGCCTTGCATTTTATACTATATATCATAAATGTTTTTAGATATATTTGCTTATATGCAAACAAATATCAACACTATACAAATAAAGAAATGTATTTTAATAAAAGAAAGGAATGGTATATCCTTTATGGATAATCAGAAACAACCTCCCTCGTATTCTCAAACAACAAACGAGTTATTTTCAGATTTAGAAACAAGTTCTACTGGCTTAAGTGAGCCAGAAGCTCAGCGGCGGTTAAAGAAATATGGACCTAACGCTCTAGCTGAAAAGCCACCAAAATCAACCTTAATGATGCTCAAAGAGCAAATCATTGATCCGATGATTTTGATCTTATTAGGAGCAGCTGCTTTTTCTGCAATTTTAAATGAATGGGTAGAAGCCAGCGTAATTTTCTTTATTGTTGTCGTTAACTCAATTATTGGAATTATTCAGGAGAAAAAAGCTCAGTCTTCTCTAGCGGCTCTCAAAACGATGAGCGCGCCAACTGCTACAGTTATGCGTGGCGGTATTGAAAAGATCATCCCTGCTAGCGAATTAGTTATCGGGGATTTAGTTATTCTAGCTAGTGGCGACATGGTTCCAGCTGATTTGCGTTTAATTCAATCTGCTAACTTAAAAATTGCAGAAGCCTCTTTAACCGGTGAATCAATTGCTAGTGAAAAGAATGCGAAAGCTGTTCTTTCAGTAGATTGTCCTCTAGGCGACAGAAAGAATATGGCTTATACTTCTTCAATCGTTACTTACGGACGAGGAAGCGGGATTGTAACTAAAACTGGAATGGACACCGAAATTGGCCAAATAGCCGGTATGCTTGAAAATGATGATGCTGGTGATACTCCATTAAAGCGAAAACTTAATACAGTAGGTAAAGTCTTAACAATCATTGGCTTAATTATCTGCGTTTTAATCTTTGCAATTGGTGCCTTTTACGGCCGCCCACTTTTACCCCAATTTTTAGTAGCAATTTCTTTAGCAATTTCAATTATTCCAGAAGGTCTACCAGCAACTGCAACCATTATTATGGCGCTAGGCGTGCAACGAATGGCAAAACAACATGCCTTAATTAAGAAGTTGCCTGCTGTTGAAACTCTAGGAAACGCGACGGTTATTTGTTCTGATAAGACAGGAACATTAACGTTAAATAAAATGACTGTAACTCATTTAGCTAATGGTGATGATTTCCTTAATAAAAAAGTTCTAAGTGTAGAAAAAGCAAGTAAGGATTCTAATTCATATAAGCAATTAATCTATGCATCTAGTCTTTGTAACGATGCTAGTTTTAATTTAGAAAATCCTAAAGAAGTAATTGGAGACCCGACTGAAGGTGCACTTCTTCCTCTAGCACAAGATTTAGGTTACTCGGCTCTTAACTTAAGAAAAGAGTATCCAAGACTTAGCGAATATCCTTTCGATTCAATTAGAAAGAGAATGACTACGGTTCATGAAATAAACAATGAATACGTCGCTTACACTAAAGGTGCGCTCGATGAGTTACTGCCACTTTGTGACTACATCTACACAAATAATGGTATGCGTAAATTAACTAAGTCAGATAAAGATAATATTCTTACCTTATCGCACAAGATGTCTGATCAAGCATTAAGAGTCTTAGGCTTTGCCAGCAAAAATATGCTAAACCTGCCTCAAGAAGGAGAAAATATTGAACAGCATTTAGTTTTCTTAGGTACAGTCGGTATGATTGATCCTGCCAGAGATGAGGTTAAGGCATCAATTAAGATGGCTCGCGAAGCTGGAATTAAGACCATTATGATCACGGGTGACCACAAAAATACAGCAGTCGCTATTGCTAAAAATTTAGGTATTTATACTAATGGAAACACTGTTATTTCAGGTACTGAATTAAACGAAATGACAGATAATGAACTAGATCAAGCAGTTAAATCCGCCACTGTTTTTGCCCGCGTTTCGCCTAATGATAAATTAAGAATCATTCAAAGCCTAAAACGAAATAATGAAGTAGTAGCCATGACAGGAGATGGGGTCAATGACTCACCCACCCTAAAGGCTGCTGATATCGGTGTTGCTATGGGTATTGGTGGTACTGATGTTGCTAAAGATGTTTCAGATATGATTTTACTTAATGATAGCTTTACAACAATTACGGCAGCAATTAGAGAAGGTCGAAAAGTATATCGCAATATTCAGAAAGTAATTCAATTTTTACTAGTTGGTAATATTGCCGAAATTACTACTTTATTTGTAGCTACAATCTTCAACTGGGATGCACCGCTACTTGCTGTGCATATTCTCTGGGTTAACTTAGCTACAGCTAGTTTGCCTGCTTTAGCTTTAGGAGTAGACCCAGCAAGTAAAAATATCATGAAACATAAGCCAGTAAAGACTGGAACTTTGTTTGAAAAAGACCTTGTTTGGCGTGTTATCAGTCAAGGAATTTTCGTCGCCTTAATGACCTTAATAGCTTACTGGATTGGAGAGTCGTTTGATAATCCAATTGCTGGTCAAACAATGGCATTTTGCGTTTTAGCCTTATCCCAAATGCTTCGCGCATTTAACCAACATTCTAATACTGATCCAATCTGGGTTAGAGGCAATAAAATAAATGTTTGGTTGATTATCTCCTTTATTGTTTCAGCGGTCCTAATGGGAATCATTCTTTTCACTCCTAACTTACAAACTCTCTTCCATTTGACTAGTCTTACTTCAAGACAATGGTTAGTAGTAATTATTCTTTCTCTCTTCTCTATCCTGCAAGTTGAGATAAGCAAGTGGATTAAGAAGCTAATTAAAGCTAGACAAAAAGAAAACAAGCTGCAAACAACCAGTGACTAACATAATATAATAATTTAATTATTATGAGCATATTTTTCGACTTATGATGATTTAATTTATATAATATAAGTATAAATTTAACACTTACATCTGGCATAAAGACTTAAACAACCTTTATGCCTTCCACTTTTTGGTAATCAAAATAATCGGTATCGTAGATACCAAAACAGCCAAATTGTAGTGACCCCCGAACTTCGGACACGGATTCATCCTTACACAAACTATTTTACGGTCTCAAAGAAAGAGCTTTCAATGTCTATATACAATATTTTATATACTGTTTTAGCATAATATATATTTATGGAATATTATTTTTTTAAGATTAATTGTTGACTAAAAGTAAGTTATAGGATATTATAACTTGTGAAAAGTAAGAAAGGAGCTAATGATTATGTTTAATGTACGTCAAGCAAATTCTTGTTGTTGTAATTGTCAAAAAATTTGGCAATTATTTGGCGTACAGTCATTAGTTCACTTCAGGAATTTCTCTAGTTAGAAACTAGCTTTTCAAAGTTATAACTATGATTTTTCTCAAGAGCTGTTGGCACTAGGCCAATGGCTCTTTTTTGTTTGCTTAGAATCGGGGTTGAATAAATTGCAAACTACTCTCATTGTTTTAGTAGCCGTCGCTATTCTAGCTGGCATGGCTTACTTACATAAAAAGAATTGGGGATTTACCAAGCTAGTATTTCTCTCATTAGTCGTTGGAATCGTCTTTGGAGTTTCTATTCAATTAATGTTTGGTGCCAAAAACGAGATTGTAAAAAATAGTATTGATTGGATTTCCATTGTTGGAGATGGGTATGTCTCCTTATTACAAATGTTGGTTATCCCACTTCATTAGTTGGTGCCTTTACGCAATTAAAAATGACTACTAAAATCCGAAAAATTGCTACAAGTGTCTTAGCTATCTTGCTAGGAACTACTGCAGTTGCTTCATTCCTGGGCTTTAGCAGTGTTGCAATTTTTAATTTAGGCGGAGCTGGCTTTGCTAAGGGAATGACTGCTTCTTCAACTGCTCTTAGTGCAATTAAGGACCATCAAGAACAATTGAAAGGCCTAACTTTACCGCAACAAATTACTTCGTTTTTCCCGCAAAATATTTTTGCCGACTTTGCAGGAATGCGTTCAACTAGTACAATTGCAGTTGTAGTTTTCTCTATCTTTGTCGGAATTGCATTCTTACAAATTAAGAAAGAAAAAGCTGAAGTCGCTGCTACCTTTGCACGTGGTATTCAAGCATTACGTGCAATTATCATGCGGATAGTTAAAATTGTACTCGAACTCACTCCATACGGAATCTTTGCTCTAATTGCTAGAACTACTGCAACTAACAGTTTCGCAACAATGAGCAAATTATTGGTCTTCATCGTTGCCGCTTATGTTGCAATAATAGTTATGTTTATTGTTCACGCTGTTTTACTTTTAATTAATGGAATTAATCCTATTACTTACTTTAAGAAGGCGTGGCCAGTTTTAGTTTTTGACTTCACTTCCAGAACTAGTGGTGGTAGTTTGCCACTTAATGTTCGTACTCAACGTGAATCAATGGGCGTTAGCGACACAATTGCCGATTTCGCCGCTAGCTTTGGTTTAACTATTGGTCAAAATGGATGTGCAGGTATTTACCCATCGATGGTTGCAGCAATTACTGCTCCCCTTGTTGGAGTTAATATTTTCTCATGGCAATTTGTCTTAACCTTAGTTGTAATTGATGTTATTTCAAGTTTCGGCGTTGCCGGTGTTGGTGGCGGTGCAACATTTACTACTTTAATGGTACTTGGAGCACTTAACCTGCCAGTTACAGTACTTGGAGTTTTAATTGCTATTGACCCAATCGTTGACATGGCAAGAACTGCTCTTAATGTTAATGATTCGATGGTCGCTGGTGTAATTACTGCTAAGCGTACTGGTGAATTAGATTGGAATATCTTTAATAATCAAAAAGATGATGTAGATACTGAAATTGAATAATTTTTATAAATATTCTTGACATTATTATTTAGTCATTGTAGTATTATGACAACAAAATTAATTAAAGCTTAGAAAAGATGAGTAAGCACTTAATGCATCTCACAGAGAGTCGGAACAGGTGTAAGCCGATGTTGCTAGAGTGAAGAAGATGGTCTTGGAGCTAAATTAAAATGCGAGCTATTTAAAGTAAGCAATTTACGATTGACGTACGTTATCACGTCTGAGTCTTCCATATTTTGGAGTACTTATTAAGGAACTGATTGTGAAATCGGTTTGAATATAGGGTGGTAACACGGTATTAAGCGTCCCTAGTGTAGTGTAATAGCTATACTAAGGACGCTTTTTCTTTTGCCGATTTTTTTTTGTCAAAGGAGGGATCATTATGAAAAATAAGAATATTATTTTTAACGAACGGGTATTTAATCGAATGTGCTACTTAAATATGATCCTTCTTGTTAGTGGATCCTCAAAAAACATTTAAGTGAAAAATTTAGTTAAAATTAAGAGGTAGATTACTATGACAGAATTAGCACATTTCGACATTGTTGGTAGTTTTTTAAGACCGGAAGAATTAAAACAGGCTAGAGATAAATTTAATCACGGAGATATTTCGCAAGCTGAACTAATTCAAGTAGAAAACCAAGATATTGAAAAGTTAATTCATACAGAAGAAAACTTAGGCTTAAAAGCTGTAACTGATGGCGAATTTCGTCGCAGTTGGTGGCATCTTGAATTTTTATGGGGTTTAACTGGCGTTAAAAAATATGATTATCACGAAAGCTACAAGTTCCATGGCGCTAAAACTAGAACAGATAATGCAGAATTAGCTGGCAAAGTAGCTTATAATCCCGAGCATCCATTCTTTAAAGCGTTTGAGTTTGTTAAAGAGCATACTAATGTGACTCCTAAACAAACTATCCCATCCCCTACACTGCTTTTTAGAGATAACCGATCAGATAATTGGCCTAATTTTTATAATAATAAACGAGCTTATCTTGATGATCTGGCTAAAGCGTACCATGAAACAATCAAGCATTTTTACGACTTAGGTTGTTGCTATCTTCAAATTGATGACACAACTTGGGCTTTTTTAATCAGTAAATTGAACGAATCCAAAAATGATCCCAAGGAACATGAAAAATATATTCAATTAGCGGAAGATTCAGTGTATGTAATTAATAAGTCACTAGAAAATCTACCAGATGATCTGACTGTTGCTACACATATTTGTCGTGGTAATTTTAAATCTACATTTCTTTTTTCAGGCGGATATGAACCAATTGCTAAGTATTTGGCGCAATTAAATTATAATCGCTTTTTCTTAGAATACGACAATGACCGTGCTGGAGATTTTGCTCCAATTAAAACAATCTGGAACAACCGGGATGACGTCACAATTGTTTTAGGATTAATTACATCAAAAGATGGACAGTTAGAAAATCCTGCTGCAATTATTCAAAGAGTTAATGAAGCAGCTAAATTAGTTCCATTGTCTAACCTCGCGCTTAGTACGCAATGCGGCTTTGCCTCAACAGAAGAAGGTAATATTCTCAGCGAAGCTGATCAATGGAAAAAGATAAAATTAGTCGTTGATACTGCTAACAAAATTTGGAAATAAAAGATATTTTTATAAGGAGGAAATTTATTATGGGTAAAGTTGAAAGTTTTGAATTAGATCACACTAAAGTTAAGGCACCTTATGTTCGCCTAATTACTGTTGAAGAAGGTAAAAAAGGTGACAAGATTAGTAATTTTGATCTTCGCTTAGTTCAGCCAAATGAAAATGCCATCCCTACTGGAGGCTTACATACTATCGAGCACTTGTTAGCTGGATTATTGCGTGACCGTATTGACGGCTACATTGATTGTTCACCATTTGGTTGCCGAACGGGCTTTCATCTTTTGGTTTGGGGTACCCCATCAACTACAGATGTTGCTAAGTCTCTTAAGGAAGCACTTGAAGAAATTCGCGATAATATTCAATGGGAGGATGTTCCTGGCACTACTATTGAATCTTGTGGGAATTATCGCGACCATTCTCTATTTTCTGCTAAACAATGGTCAAGAGATATTTTAGAAAAGGGTATTTCTGATGATCCATTTGAAAGAAACGTTGTAGAATAATTATTTTTGAAAAATAGGACAAAAAAGATGCATATTACTGCTTCAAACAGTAAAAATGCATCTTTTTTCGTATTTATTTAATTTTTATCTTTTTCTTCTCTTCCTTTCTTTACCACCAATTAGTCCAATTATTGCTCCGACAGAAGCTAATGCTAATCCTGCTAATGATAAATCTGTCTTTTGACTACCAGTTTGCGGTAGTGTTGTTCTAGCACGATTAATTTGCTTAGCTGATGTGACATTTCTTGAAGTTCCAACTGCATAAGTTGTATGAGTTAAGCTTGTAGAAGTGTTTGAAGCTTCAACATTCTTGGACTTGTTTAACTTATTAATTTGCGTAACAATCTTAGATGATTCTGTTTCATTCGATTGATTTGGCTTGTTAGGTATTGTTTGTTCTTCCGGCTTTGTTGGTTCACTCGGTTGTGCTGGCTTACCTGGTGTTGTCGGTTCTTCCGGCTTCGTTAATTATTCTTTTTATATCTCTTCCACAAGACTATATTCCAAATTATCAACAAGCACACCCAAAAGATGGCTAAAATCATCGTATTCCGATAACCACTGCCTTTTTGAATCTTATTCCAAATTTCGCTAAAGTATGTTCCACTTAAAAATGCACTTAAAGTTATTATCGATAAAGTCAAAGACATCTTTTTAATTTTATCCTTAACCTTCATCAACTGAATCCAGTTATAGACAACTTCACAAATTACGATTAGTAAAACTAGTAAGTCATACCACCATTCACGTTGTTTAACAAATTCATCAATGGTAGTAATAAAATAGTAACCTGCAAGGATTGCAAATATGTTTAAGATCAACAGCTGTCCCACAACTGTACTTTGTTCTTTTTCTTTCATGATCTTCCGCACTTTCTACTTTTTCTCTTCATATAAATTATAAAACATTCGCTTTTTTTCTTGCTTAACCTAAGGCTCTATTTTTTAAACTGCCGCCAATAATTAGCAAGGTATTCTGTTGTTAAACTCACGGGATGGTTAATCAAATCTTGTGTTTGTCCTGCAGCAACGACTTTTCCACCATTTTTTCCGCCACGTGGCCCTAAATCAAGAATATTATCTGCATTAACTATCATATTTAGATCGTGCGTAATCGTAATAATAGTTGCCCCTTGATCTAGCAATTTCTGCATTACTTGAACTAAAACTTTCACATCAAGCGGATGTAATCCAATTGTAGGCTCATCAAATACAAATAAAGTATCGTCCTGTTTATGACTTAAATGTGTCACTAACTTCAAACGCTGTGCCTCTCCACCAGATAAAGTTGGTGTACTTTCACCTAAATGAAGATAATCTAGTCCAACTTCTTTTAGTAAAAGTAAGTCACGCTCAATTTTAGGTTCTTTCTTAAAAACAGGAATTGCTTCATTAATATCTAAATTTAAAATATCAACAATTGAGTAGCCGTTCCACTTTACTTTTTGAACTTCTGGATTATAGCGATTACCCTCACAGGTCGGACAAATCTGCTGCATATCAGGTAAAAATTGAATATCTAAAGTTACAATTCCAGTTCCACCACAAGTTGGACAAGCTCCCTGTTTATTATTATAAGAAAAGTAAGTTGGCGTATAATGCTTGTTTTTTGCAAGAGGCTGCCGAGCAAATAATTTACGTAAATTATCCATAATTGAAGTATATGTAGCAACAGTTGACCTGGTACTTTTACCAATTGGTGAAGCATCAACGCTAACTACTTGATTAATTGGCGATTCAAAGTTCTTAACTTGTTTAGGTAAATTTTCACCTTTTGCTTGTGCTTGAATTGCTGGAACTAAACTATCTAGAATTAAACTTGTCTTACCTGCTCCAGAAAATCCAGTCACAGCAGTTAATTGATTAACAGGAATATTCGCATGAACATCTTGCAGATTAAAATAATGATCCACATTAAATGAAATTTTTACAGAGTTAACTTTTTCTGCTCGCTTTCTCGCCATTAATTCAGCAGTTCCATCAAGATAAGGTCTAATTAAAGATTGCTTGTCTTTTTTTATTTGATCAACGCTACCTTGATCCAGAATTTCACCGCCTTGTTCACCTGATCCTGGTCCAATCTCAATTATTTCATCAGCTGCTTTAATAATATCCACATTGTGATCCACAACTACTAGTGAATTTCCTTGTGCTACTAATTTATGCAAGACCTTAATTAAGCCGTCAACATTAGCAGGATGTAGCCCAATTGAAGGTTCATCTAAGACATATAAGACGCCAGTTGTTTCTGTTCTCAACGTGCGTGCTAACTGAATTCGCTGTAATTCACCTGTGGATAAGGTGTTACCATTTCGAGCCATTGTTAAATAATCTAAGCCTAAATCAAGTAGTGGTTGCAAGTTCTCCACAAACTCTGTGAATAAGGCGCTGGCCATTTTATGCATCTCAGCTGGTAAACTCTTAAGCACTTGACCTTTCCAAGCAATCAAATCATCTAACGGCATTTCAGCTACTTCGTTAATATTTAAACTACCTACTAATTGCTTCAATAATCCTGGCTTTAATCTTGAACCATGACACACAGGACAAGTCTGATATGAGAAAAATTCTGAAATCCGCTTTTGCGCACGTTCGCTCTTACTAGTTTTGGCAGAACGTAAAACAGCTTGGTGAGCATTTTCATAAAGGGCATTAAAATCATGAAAAACTCTCCCCGTTCCTGATAAAAAGTCCATTTTATACTTCTTTTCAGGACCATTAAGAACAAAATCTTTTTCTTTATCAGTTAAATCCTTATAGGGAATGTCAATCCTAACCCCCGCATGTTCTGCTACATTGGGCATAAAGTTTCTACCAGGTAGCGACCACGAAGCAACTGCTCCCTCTTTAATAGAAAGACTAGGATCAGCAATAAACTTACTATCATCCAATTGACGTACTTTTCCTGTCCCGCCACATTCTTCACAAGCTCCATCAGAATTAAAGGCAAATTGCTCAGCACTTGGCACATAAAACTTAACACCGCAAACTGGACAAGTAAGTTGACCCATTTCTTCACCTGACTTTGCCATTGCTTCTGCAATTTCTAGACTTGGCTTTAAACGGTGACCATTAGGACAAACAGGCGAGCCTAATCTAGAAAAGATCAACCGCAAAATATTAAAAGTTTCGCTCATTGTTCCAACCGTTGCTCGTTCAGATGGAATAGTTGGACGCTGTCTTAAGGCTAAAGCTGAAGGAATATGCTTGACGCTAGTAACATTTGCCTGATTTCCCTGTTTGATTCGTCTACGCATATAAGTAGACAAGGCATCTAAATATCTTCTGGAGCCTTCTTCATATAAGATACCCATGGCTAAAGAAGATTTTCCTGAGCCTGACAAACCAGAGATTGCAACAAATTTATGAAGTGGGATATTAACATCAATATTTTTCAGATTATGAACACGTCCCCCACGCACTTCAATCTGAGTTGGTAACTTTGCAGTCAAAGTCAGTTCCTCCTTACTTTTTATCAACTACTATCTTACAACAATTATTATAAAAAATAGCCATTCTATCGTTGCCTATACAAAAAGAAGACTCTGCTTTATAAAAGTAGAGTCTTCTGAAGGAATATAACTATGAAAATTTAATTTAAGGAAATATTATTTAAGAATTGTGTAATTTGTGTTGATATATGAGGATTATGGAAAATTAAAATTTTAAGTTATTTTGTAAAGCCAACATCGTACCATGAGTTTGCTGATGGCTTAAGTGACCAGCCAGTTACCTTGTCGTTAACTGCAGTTACTGACCAGCTGTTTGTAGTAAGTACAACGTAGGCATTGTCATACATCCATTGTTGCCACTTATCAAATGCTTGTACACGGTACTTGTGGTTGAAGGCCTTAGTTGAATCAATGTTAGTAAGAAGCTTAGATTGAGTTGGAGAAACAAAACGAGCCATGTTGTATGGAGCACCTTCACTGTAAAGGTCCATTGGTGATGGTTCAGATGATAGGCTCCAACCACCTTCAAAGACATCAATCTTAGGACTATCTGCTTGAACATCTTGTACCCAAGAGTTGAATTCCATTGGACGGCCACCAACAAATTTAGCATCTAAGCCAATCTTTTGCCATTGTTGGATGTAGTTAGTCCAGATCTTTTCAGCGTTTGGTTGTGTATTACGAACAGCAACGTTAATAGTTAACTTCTTACCATTTGGTTGACGACGGTATTTTTCACCCTTACGCTTCTTGTATCCAGCCTTGTCTAACAATTCATTGGCTTTCTTCAAGTTGTATGGGTAGCCCTTGATACTCTTGTCGGAGAAGTCTCCAAATTGTGCTGGAATTAAAGTATTAATACGGAAAGTCAAGCCATTGCTGTAGCGCTTGTTAACAGCATCAATGTTCATTGCATAAGCCATCGCTTTACGTAATGAAACATTGTTCATCTTAGCGTTCTTATCTTCAACGTTCTTACCAGTCTTCTTGTCAAACTTACCTACCTTAAAGCCTAAGTAGTTGTAAGATAGAGGAATCTTACCAATGAAGTTAACGCCCTTAGTATCCTTAACATTGTTCCATTGAGAGTTGAGCACACCAGTAATATCAAACTTGTGACTCTTAATAGCTTGAGAAACAGAGTTAGTTCCAATTACTTCCATAGTAATCTTGTCTAAGTTTGGCTTACCACGCCAGTAATGTTCGTTTGGTACGTAAGTAACTGATTGGCCACGAACAACCTTTTGAACCTTGTAAGGGCCAAAGAATAGTGGTTGCTTCCGAACTTTATCATCAGATAAAAGTTTCTCAAATGGAACATCTTTCAAGTAGTGGTATGGTTCTGCACTTTCAAGGAAGTAACCGTTACCTGATTGAAGCATACCTGGCTTCATTTCTTTGAAGTGAAGTACAACTTTTCGACCATTTTCGCCATTTGGCATTTCAATACCAGAAATCTTGTCGGTCTTACCCTTATGATATTCTTCTAAACCAACAAGGTTAGCTAAAGAATCTGTATATCTTGAAGTCTTGGTCTTAGGGTTACCAACAATTTCGTAGGCGTATTCAAGGTCCTTAGCAGTTACTTGCTTACCATCAGACCACTTAACACCCTTTTTAACTTCAATGGTAATTGTCTTTGCATTCTTATCTAACTTAAAGGTAGCTGCACCCTTATTGTTAATCTTATAGCTATCGTCAACACTAAAGAGTGATTCTAAACCTGGACTTTGAATTTCTGTGTCAGTAGACGTATCAGATAATTCTGGTAAGAAAATACCTGTGAAAGGTGAGTCACTTTCAATTGCATACTTTAATGTTCCACCCTTTTTAACTTGTTTCTTAGGAACAGCTTCTTTAAAACTAACTTTCTTATCGCTAGCGTTATTATTGTTGTTATTCCCACAAGCAGTTAAAGTCAATGCCGCACCGGACAATACTGTAATTGCTCCTAACCACTTAACTTTTTTCATTTTTTCTCCCCCTTTGTGAGATGACTTAAATTTCTTGATTTTTATTATATGATATTAAAATGAAAAAAACAATACAAAATTAAAATATTTTTTGGCTAAATTTGTGTTTTATTAAAAATCTAGTATTAATACACTTGTTTTCTTTAAGGTGTAATCTGATAGTTATAAAAATCGCCAAAAGTTATAAAGAGTTATAAAAAAAGAAAGATGATACACATGAATAATAATCCTTTCAATCCTAGTTTTGGCAAAATACCAAGTATCTTTCTAAAACGCGATAATTTATCTCAAAGAATAATCGACGAATTAAATAGAGAAAATTCTCCATTTCAAACTTCACTCATTTATGGTCAAAGAAGGTCTGGAAAAACCACCCTTATGTCTGAAATTTCTTCTAAACTTAAAGAAAATAAAGACTGGATCATTATTGACTTAGTCTTTGATAATGATTTACTCATTTCTCTAACTAATCAACTTCAAGAGCATTTATTAAAATTAAAACTAATTAAAAATTTAGATATAAAAATGAACTTTCTCGGCATTGATATTAATGCTTCCTTAGCTCAAAACATCGATGCCAATTTTCAACAAATTTTGCAAACTAGTCTTGAGAAATTAACAAGAAAAGGCAAAAATGTGCTAATTAATATTGATGAGGTTCATTTAACTCCTTTACTAAAGAAATTTGCCAATTGTTATCAGATCATGATTAGAAAAAATCTTAAGGTTTCTTTATTAATGGCTGGTCTTCCAGAAAATGTTTCTGAAATTCAAAATGACGATGTCTTAACTTTTCTTCTGCGATCTAATCGGATTGTCCTCAATCCATTGAACTTAGAAACTATTAAACTTAGCTACAAGCATATTTTTCAAAATGCTAACTTCAATATTGATGATAGAACTATTTTATATATGACCAAGCAAACACAAGGATTTGCATATGCCTTTCAACTTTTGGGTTATCATATCTGGAGATATGCTACAGAACAGAATAAAAAAACTATTTCTCTTTCTTTAGTAGACGAAATCTTAGACATTTATTTGAGTGATTTAAATCGCAATGTTTACTTTAAGGTTTACAATGATCTTTCTTCTAAAGAAAAAGAGTTCGTGCAAGCAATGGTAAAAGTTGGAAAACAAAAAGTCAAAAGCCAAGAAATCGGGAAAATAATGAATAAAGGTGCTAATTATTTAGCTGTTTATCGGAGAAAATTAATAGATGATCAAGTAATCAAACCTGATGGTTATGGCTATGTCAGTTTCTTACTCCCGCATTTTGACAAGTTCATTGAACAAGAAATGATCTTAAATGAATTCTAAAATTTCAAGCAAAAAAAGCTGGTAATACCAACGCCATTTCAAGCGAAGATATTGCCAGCTTTTCTTTATATTCTCTTTTCAGAAGTTTTTTTAATTTTTCTCTTAGGTGTGAAATTCAAAGCTAAAACTGCCCCAATTACTAAAAATGTTCCTAGCCAATCCATCCCTGACATCACCAAACCAAAGATTAAAACTGAACCAACTGTAGCTGATAAGGGCTCAAAAGCATCAAGCAAACTAACCGTTGACGGCTTAACATAACGTAATGCATTCGCCATAATCTGAAAAGGCACTATTGTTCCCAGAATAATAATTGCTCCTACCCAGAGCCAAACTTTTGGTGTGTTTGGAACAGCGGGAAAGCTAGGATGAAAAATCACCAAACCAAGTCCAGCAAAAATCATCCCCCAACCAGTCAAAACTAAACTCGATATTCTTTTAACAATTTTAACTGGAATCAACGTATAGCTTGCTTCACCTAGAGCAGATAATAAGCCGAAAAATAATGCCACTGGAGTAATTGTTAAATGATTTAAATTTCCATGAGTTGACAGCAAAAATACACCAATAAAAGCCATCAGTGCTGCTAAAATATCTAACCTTCTTAAAACTTGCTGATGAGTTAAAGCAAGATAAGCAAGAACAAAAAACGGTCCAATAAATTGTAAGATAGTCGCAATCGAAGCATTCGCCATTTCAATGACAATAAAGTAAAAAATCTGTACTGGTAATAAGCCAAATACCCCATAAGCAATAATGTGCAACGTATTTTTCTTGTCTTTTAAAACTGAAATTGGCTTTTGATGTAAAATTGTCGCAATGATTAATAAGACAATCCCAGAAATAATTAGTCTTACTTGTGTCAGCCAAATAGGTGTAATTTTAGAACTGATCTTAAATAAAGACTCCGCAAATAAACCTGATATTCCCCACATCACAGCTGCTAAAGCTGCCAAAACTGTCCACAGTCTGCTTCTAGTAACTTGCTTATCCATCCAGCTTCTTCCTCACAAATAAAAATCAATCTAAATCATCATAGCATAGTTACTCTAAGCAATCATTGTAATTTCGACAAAAAAATACTGTTCAATTAGGTAAGCAACCTGAACAGTATTTTTTAATTCAAATTAATCTAAATCTTTTCCATCAGATTCAATAACTTTCTTGTACCAATAGAATGAATCCTTGGGCATTCTCTTTAAAGTACCGTTGCCTTCATCATCTCTATCCACATAGATAAAGCCATAACGCTTACTCATTTGACCGGTACCTGCAGAAACTAAGTCAATACAGCCCCAAGTAGTGTAACCAATTAAATCTACACCATCATCAATTGCACGCTCCATTGCCTTAATATGCATTCTCAAGTAATCAATCCGGTAATCATCATGAATCTTGCCATCATCGCTGATCTTATCAACTGCGCCAAGACCATTTTCAACAACCATCATTGGAATGTCGTAGCGATCATACATTACTTCAAGATAATATTGAAGTCCATCTGGATCAGTTGCCCAGCCCCATTCGGAATACTTCAAGTATGGGTTCTTAACACCAGCAGCAAAATTACCACCAACTTTATCTTTTACTTCATGGGTAGTAATAATGTTAGACATGTAGTAAGAGAAGGTATAAATGTCAACTTTTCCTTCAAGCAAGTCTTTTCGATCTTGCTCGGTAATATTTAAATGAACATTATGCTCATTCCATAAACGCTTAGCATAAGTTGGGTATTTACCTTTTGCTTGCACATCACCGCAGGTTCCCACATATGACGGTTAGCCAAAATATCCTTAGGATCTGGTGTTAATGGATAGTCTACAATACCACAAATCATATTACCAACTACATAGTTAGGATCTAATGCATGAGCAATCTTAACTGCGCGAGCACTAGCAACAAATTGATAATGCAACTTTTGGTAGGCATGTTGATATACCTTATCATCAGTTACATTATTGCCAAATGCACTCAGCATTAAAAGCGTTGAGTTAATTTCATTAAATGTAAGCCAGTACTTAACCAGTCCTCTGTATTCTTCAAACAAAGTAGTTGCATACTTAACATACATATCGATCATTTTGCGATCTCCCCAGTCATGGTATTTTTCGCTGAGGTATAGGGGATCTTCATAGTGAGAAATAGTAACTAAAGGTTCAATCCCGTACTTTTTACATTCTTCAAATACACGGTGATAAAAATCTAACCCAGCTTGATTTGGCTTTTCTTCATCGCCTTTAGGGAAAATTCTAGTCCAGGCAATTGAAAGGCGGAAGATCTTAAAGCCCATTTCAGCAAACATCTTAATGTCTTCTTTATAGTGGTGATAAAAATCAATTGCCACGTGGTTTGGGTAATATTCATTTGGATCAATTGCACCAACTGCGCCTTCTGGCAAGCCCGCCCCAGGAATACCTGGAGTTTTTTCTAACTTACCATTCAACTTATAAGTCAACATTCTTGGTGCATCTAAACTACCAGCAGTTGTAATATCAGTGACTGATAATCCTTTTCCATCTTCATCATACGCACCTTCAATTTGATTTGCGGCAGTAGCTCCGCCCCATAAAAAGTTTTTTGGAAATGACATTTATATTTCTCCTCTTTTTCAATACTAGTCATTTTTATTATATATGAAATCGATTACATTATCTAAGCCATTTGAGGATTTGAACTAGCTGCTTCTGTTTCACTAGCTCCTTCTAAGTCTAAAATCTCTTGTCCTACTTTTACCTTGCCTTGACTTACAACAGTGATCTTTTCATAATCTTTTGAGTTAGTAACTACGATTGGTGTCGTTACAACATAGCCCTTAGCATGAATTGCATCGATATCAAACTTAACTAATTCATCACCTGCTTTAACTTCGTCGCCTTTTGCAACTAAGGTTTCAAAACCATGTCCTTGTAAATTAACAGTATCCATTCCGATGTGCATCAAGATTTCTGCACCATCGCTTGTCTTCATTCCGATAGCATGTCCTGTTGGGAAGGTCATTACAACTTTACCATCTGCTGGTGCATGTAGAACTCATTCGCTAGGCTCAACAGCAACGCCTTCACCCATAGCACCGCTTGAGAAGACTTCATCTTTTACTTCTGATAGTGGCAATAATTCACCAGCAAGTGGACTAACTAGTTCAGTTGAAACATTTAAGTCGCTAGTACTTGCTAAGCTTGGGGCAGCTTTCGCAATAGTATCTGCTTGGTTTGCAACTTCTTGAACAGTCTTTGCTTGTTTTTCATCGTAAGCTTGATCAACACTCTTCTTGCCAAGAACCATTTGTAAAATAAATCCAAGAACGAATGAGACAGCCATTGCAATCATTAAACCGTAAACACTCATGTCAACACCAGTCTTTGGACCAATAGCAGCAGGGATTACGAAGACTCCCATACCACCCATCATGTACATCTTAGTACCGAAGAATCCAATCAAACCGCCACCAATACCAGCTGCAATACAACTTAAGACAAATGGCTTTTTACGTGGAAGAGTTACACCATAAATAGCTGGTTCAGTAACACCGAAAATTCCTGATAAGAATGCTGGAAGAGCAATACCTTTTAATTTTTGATCTTTAGTTTGTAATAAGATTGCTAAAACAACACCAATTTGTGCAAATGAAGCACCTAATGATAACCCTAAGATTGGGTCATAACCTAATGCAGCAATATTTGACATCATCACTGCAACAAATCCCCAGTGAACGCCGAAGATAACGAATACTTGCCAGAAGCCACCAAGTAAAATGCCAGCTAATACTGGACTAAAGTTGTAAACAGCTGAAGTAATGGCAGCAAGTGCATTACCAATCCAAGTAGCAAGTGGCCCGATAATTAAGAAAGTTAAAGGAACTACAATCAGTAAAGTAACAAATGGAACTAAGAAAGTTTTTACCACAGTTGGAATCCATTTCTTGCACCATTTTTCAACAACAGAAGCAAACCAAACCGCTAAAATAATTGGAATAACTGTTGAAGTATAGTTCATTGAAATAATTGGAATACCTAAGAATGTAGCATGAACTTGTGAATGTAAGAACGTTCCGTTAAATAAATCAAACAAAACTTTTTTGCTGCTATTCATTGCTACCATTGCTGGATAACACATTGCAGCACCAATTGTAATGGCTGTAAAGCGGTCTACCTTAAACTTCTTAGCACTAGTAATTGCTAGAATAAGTGGCAAGAAGTAAAAGAAACCATCCCCAATCGCATATAAAACTTCATAAGTACCAGAGGTTTTAGCAAGCCAGCCAAATGAAGCACACATTGCAGTTAAGCCTTTAATCATACCTGCTGCAGCCATTGGCCCCAAGATCGGAGTAAAGATACCTGAAATAAGATCGATAGCTTTATCCATTAAACTCATATTGCTGTCATCTAAATCATCATCAGCAACTTGGCCACCACCAGAAAAGCCACCTTCTTTTAAGACTGCCTCGTATACGTCAGCAACTTCATTACCAATAACTACCTGATATTGTCCACCAGCTTTAACAACTGTAACAACACCATCAGTATCTTTTAAGGCATCATCATTAGCCTTTTTTTCATCTTTTAATTTAAAACGCAAGCGTGTTGTACAGTGAACAACGCTGATTACGTTGTCTTTTCCGCCAACGTCCTTAATAATCGTTTTTGCTAGAGCATCATAGTTCTTAGCCATAGCTTTTTTCCTCCCAATAATAAAACCCAAGCTACTCAAAAACTAGAGAACGTAAATGTTCAATGTCTTTCAGTAACTTGGGTTCTTGCCTAATCGAATTAGTAACATACCTAAATATGAAAATATTTAATTTTCTTGGCGGTTTGTCACGCGCCAAATATGTAAATAAGTTGCGATTCTCTCTGCCGTATCATAGGCATGATTGTACTTAATCTTCATAAAAGCTAATAGCGAATCATCAAGTTCGCCACTTTTTTGATGCTTATTTCTTAAAAGTCTTACCAATAATACTCTTAAGTGAGTAATGAAGCGACTATAATTAAACGACTCTGTATCTAAAGTCATTTGGTATTGATACTGAATAATATCAATAATCCCGCTAATCAACTCAGTGATCTCAACTGTTTCTTGAACCTGATCATTATCAGAAGCTGCATTAACGAAGTGATAAGTCATAAAAATACTTTCACTCGGTGGTAAGTTGACTTTCATTTCTTTATTAATTAAAGCAATGACTTTTTCGCTAATCTTATACTCCTTAGGAAAAAGATTCTTAACTTCCCAGCGTGTATTAGCAGCACTCATATCAATATGATCTTCAATTCTTGAAAGAGCAAAATCAATATGGTCAGCTAAAGCTAAGTATTGAAAATCATTGAACTTCACTTTTAGAAGTGGCTCCACCATCTGGATCACCTTATTGGTTAAATCGATGGTTGAAGCATTGATTTCTTTAACTTGATTGACTTCATCTTGATGAGAAGTAGCGGTAAACCGCCTTTCAATTTTATTCTCATCAATCTTATCGCCTTTCTTTAAGCCAAAGCCCACGCCTTTGCCCAGGACTACTTGTTCTTGGCCTTGATCGTCCTGAACCAAGGCTGCACTATTGTTAAATGTTTTAAGAAATATCATCCGACGAATCACCTTTATATAGAAAAAAGCTACCACAAACTACAATATACACTTTAAGTATATCATCATTATTTGTAGTAGCTCAGACCTGATCGCATCAGTAATCCGCTTATTTACAGTAATTATAATAGCGCTTTCACATATTTGTGTCAACAAGCATTTGCAGAAAAATGCTTATTTTCATGTCAGAAAAAAAGGCTAGACCTTAATGTCTAGCCTCTTTTAGGGATTTCAAACTAACTTTTATTATTTTTGACGCTTTTTTCTATCTACGCCTAATCCGAATAAACTACCTACTGCGGCAATTGCTAAGCCTAAGATACCAGCTGTATTTTCTGACTTAGCACCAGTTTGTGGCAATGTATTCTTTTCAGCATGGTGATTTTCATTTACAGTAGCTGCTTTTGCAGTATTGGTTTCAGAATTAGTTTCTGTAGTCTTACCACCATTGTTGTCACTTGTTCCAGTAGCGTCTACATAGACCTTAACTGTTACATCTACGCTAGAGCCATCTGGATAAGTTACCGTAACAACGCCTGTATGTTCACCAATTGTAGAAACATTTGGCACTTCTTTCCAAGTGTACTTAGTACCTTCTGGCATATCGTTCCTGTTCTTAATACCTTCTGATGGGTTTGGAACAACACCTGGAGTAGTGTGAATTGGTTGTGGCTCTGGAGTTACATGGTTCGTACCGATAATTACTGTTACGTTAACCTTATCTTTTGAACCATCTGGGTAAGTCACAATCACAGTGCCTGTAGTCTTGCCTGGCTTAGTTACATCTGGAGTCTTCTCCCAAGTGTACTTAGTGCCGCTTGGCATATCATCCTTGTTCTTAATGCCCTTTTCTGCTGGTGGTACTACACCTGGGGTAGTGTGAACATCTTGACCTTCTGGGGTGTACGC
+>5_1#NODE_5_length_39999_cov_63.277_ID_9
+CGATCAATTGGTAACAGATATTCGTGAAATGAACCAGAAACCAGTTAAAAAGCAATTGCGTTTAGGCTTAACTACTTTATTTGCTGTACAATTTATGAAAGAAATTTCACGATTTTTAACAACCCATCCACATGTGAATTTAATATTACAGCAAGATGGCTCGCCAAAATTACAAACGATGTTAGCAAATAAAGAAATTGATATGGGACTAATTTCTTTCCCAAATACCTTACCTGAAATTATTCATATTGAACCTTTAGAAACGACTACCAAAGGCTACCATGTTTATGTCGTAGTACCAGAATCAAATCCTCTCTCCCAATATGAAAAATTAACTTTTAAAGATTTGAAAGATCAACGATTTTCATCGTTAAGTGATAATTTTATGATTGGTCGCCTACTACTAGATCGGACTCGGAGCTTCGGTTATGAGCCGAATATCATTTTGCATAACGATGATTTACAAGTACTTCTTTATAGTTTACAAAAAAATAATTCGATTTGTTTGCTGCCGATTGAATATTATGAAGTGGGAAAAAGTCAGGGACTGAAATGGATTCCTTTAAAAGATAAGTTTGACTATTTCCCCATCGGCATTGCTTTGCGCCGCGATTTTAGTATGACAGAAGATGTTAGAGATTTTATCCAAATCATTAAAGAAAATTAATGGATAATCTAGCCTTGATAAGCAAAGACGACTTTACTATCATAAAGTTTCAACACTTTTTCAAATAAGAATTTTGAGAATAAACCCGCGACAATTGGAACAACAAACCAAGAAAAGAATAAGGGTAAGATCCCTAAGCCCGCATCCAATGAAGCAAGTGGTCCCACGAGTCCAACCAAGCCAAATCCAGCCGATTGTGGGGTTCCTGAAATGTTGAATAGAACCACAGGAATTGCTGAAATAGTCGCTGTAAATAAACAAGGAATTAAAATAATTGGGTATTTAAATAAATTAGGCATCATCATTTTCATGCCGCCCAAAGAGACAGCCAACGTCACTCCCGATTGGTTGACATTCCAAGAATTAATCACAAGAACAACAGTTGTGGCTGCAATTCCCATTGCAGCAGCACCTGCAGACAAGCCATTCAACTGAATCGCCAAACCGATTGCCACAGTAGTGATTGGTGAAATAATCAGTGCAGCAAATGAACAAGCAATTAAAATACTCATGATAATTGGCTGGAAATCAGTAAAATTGTTAATCACTTTCCCAATGGCGACCGTAATTTGTGTCACATATGGATAAATCAACATGCCAAACAAACCTGCACCTACTCCAACAACGATCGGTAAAGCAATGATTTCCACTGAACCGAATTTTTTATCGATGACTAATAAAAGTAAGACTGCAACAGAAGCGGTAATCATAATATTAATGATGTCACCAGTGCCTGCACCAATAAAGCCTTTCACTTCTGAATTAAATTTAATCACGCCAGAGCCAGCAAATGCTGCACCGCCAGCAATCATCATTTTCTGTGGCGTTAAGCCAAATTGAAAAGCAATCAGTCCACCAATAATTAAAGGGGTGGCTAGTTGGAAAATTTGCGCCGCATGAATAATCATTTCGATAATCTTGTATTCTGCAAAATATTTTAAAATGGCTCCTAATACAGCATTGGGAATTAAGGCGATAATGGTGCCAGAAGCTGTTCCAGCTAACACTTTGTTAAAAAATATTCTTGGGGTTAATTGAGCATCCAGTTTATCAGTGGGCATTTTCAACACTCCTATTGATTATTTTTGTTTTTTTAGAACAAGTTTGAGAATGATTGAACTTTCTATTAGATAAAGAGCGGCCTCAAAGAAGAGCGCTTATTTCTTTGAGGCGCTTTTTATTTAACTAAAGCAAGGAACGATTTTTAATATACATCCGTATCCGCATTATATTTCGCTAAATTATCTTTAACATCTCGCAAGAACTTACCTGCTTGTTGTCCATCTAAAATTCGATGATCAATAGAAAGACATAAATTAACCATATCTGCCACTTTAAAGCCTCCATCTGCGGTTGGCACAAGGCGTTTATTAATTGACTCTACTTGTAATATCGCAGCTTGTGGATGGTTAATAATTCCCATCGATTGGACGGAACCTAGTGTCCCAGTATTATTAAGAGTAAAGGTCCCTCCTTGCATTTCCTTGCTTGCTAGCGTTCCTTGTCGGACTTCTTGTGCCAAGCGATTGATTTCTTTAGCTAGCCCTGCAATCGAATAGTTATCCGCTTGTTGAATCACTGGCACGTAAAGATGCTCGTCTGTCGTTACAGCTATGGATAAATTAACATCTTTATGATAAATAATTGAGCCATCATCCCAAGATGTATTGATTTTTGGATTTTTCTTTAACGCTTGAATGACTGCTTTGGCAAAAAATGGGAAGAAGCTTAGAGACAGGCCTTCTTGTTGTTTAAATTCATCTTTTAATGAATTTCTAAGTTGGACTAAGTTGGTCACATCCGCTTCCACCATTAACCAAGCGTGAGGGATTTCGTTGACACTTTGGACCATTTTTTTAGCAATCGCTTTACGTACAGGATCTGCAGAGACAATTTTATCTGGGCTTGTTTCAGTTGGACTAGCTGTTGCGGCGCTTTCATTTTGCGAAGCAACTGGCTCCTCTGAAATTGAAGGGCTAGTTCCTGGACTCACTGTTTTCTCAGGTGTTCTTCCCTGTGTTGGTGTAAAGTTTGTAACATCTTTTCTAGTAATTCGACCATCACGACCTGTCCCTGTAACTTGTGTTAAATCAATCTTTTTTTCTTGGGCAATTTTAAGGACTGCTGGGGAATAACGACCATTATTTTTTTGATGGGACGTCGCAGTGCTTGTTGTTGCAACCGTTTCATGTTCTTGCGCTTGTTCCGCACTTGCTTCTTTCACTGGTGCTAAAGTAGCTACTTCTGTTTTTTCGGTTGTTTCTTCTGTCTCTAACGTCATCACCGCTGTTCCGATGGGCACATCTGTATCTAGAGAAATCAGAAATTCTTTTACTACACCATCAAAATCTGATGGGACTTCCGTGGTGACTTTATCAGAAACGACTTCCATTAAGGGATCATAGCGTTTCACTGAATCTCCTGGTTTAACTAACCATTGGACAATGGCTGCCTCTGTGACACTTTCGCCTAGATGAGGCATTTTGATTTCTTTTGTGGCCATTTATTTTTTCCTCCTTGCTTCAATTAAAATTCTGCTAATTCTTTCATTGCTGCTAATACTTGTTCTTCATTGATTAAAAATTCTCTTTCTAAAGGTAATGCATAAGGCATGCTTGGACAATCAGGTCCTGCAAGTCGTTGAATCGGTGCATCTAAATCAAAGAGAGCATCTTCTGAAATCATTGCCGCAATTTCACTCATCACGCTGCCTTCTTTATTGTCTTCTGTTACGAGTAAGACCTTCCCTGTTTTCTTAGCTGCAGCTACTAATGTTTCGCGATCTAAAGGATATAATGAGCGAACATCGACGATTTCGGCATCAATTCCTTCAGCGACTAGTTTTTCCGCCGCAGCTAAAGCTAATTGCAAGGTCATGCCGTAACTAATCACGGTTAAATCACTACCCGTTCTAACGACATTGGCTTTGTCAATTGGTACGATATAATCATCTGCAGGCACTTCATCTTTTAGTAAACGATATAAACGCTTATGTTCGTAAAAAATGACTGGATCATCGGAACGAATCGCTGCTTTAATCATCCCTTTTGCATCATAAGGATTAGAGGGGGTCACAACTCTTAATCCTGGTTGTCCACAAAAAACTTTTTCTGTAGACTGAGAATGATACAGCCCACCACGAACACCGCCGCCATAAGGGGTCCGATAAACGATCGGCGCAGTCCAATCGCCTTTTGTTCTGTAGCGCATTGTCCGAGCCTCTGATAACAATTGATTGGTTGCAGGCAAAATGTAATCCGCAAATTGAAATTCACCAATTGCGCGATAGCCCATTAAACCTAAGCCGACAGCTAAACCACCAATTAAACCTTCTGTTAACGGTGTATTAAAACAACGCTCGTCACCGTATTTAGCAGCCAAGCCCTTTGTTACACCGAACACGCCGCCTTTGTCGCCGCCGACATCTTCTCCAAAAATAACTACTTTTTCATCACGAGCCATTTCTTCAGAAATTCCTAAGTTAATTGCTTCTAAATAAGTCATCTCAGCCATTATATTTCTTCTCCTCTTCTCTTATTTTGCATACACTTCTTCTAAAATTGATGTCGGTACAGGATCTGGCATTGCTTCTGCTTCATCCGTTGCTTGATTGATTTCTGCACGAATTTCTTCATCAATTTTGGCAATGTCTTCGTCTGTTAAATAGCCCTCTTCTAATAATTGTTTTTCAAAAAGCTTCACTGCATCGTTCTTTTTCATTTCTTCAATTTCTTCTTTTGAACGATAAACAGATTGATCATCGTCAGCGGAATGAGAAGTCAAGCGCGAAACCATTAATTCAATCAATTTTGGTCCTTTTTTCCCGCGAGCCGCTTTTACTGCTTCTTTAAATGCTAGATAGACTTCAGTAAAATCACTACCATCAACGGTTACACCTTCAAAGCCATAAGCTTTCGCGCGATCGGCCATTCGTTTATTGGCATACTGTTCTTCAATTGGGACAGAAATCGCATATTCATTATTTTCAACAACAAAAATGACTGGTAATTTTTTTACGCCTGCAAAGTTCATAGCTTCTTGGACTTCTCCTTGATTGGCAGAGCCTTCCCCAGTGGTGGTCAATGCAACAAAATCAGCTTTTTGAAGTTGCGCTGCATAACCAACACCTGTTGCTAATGGCATTTGTGTACTTACTGTTGAAGAGAAGGAAACAATATTATGCTCTTTTGAACCATAATGATTCGGCATTTGACGACCATGGGAAGAAGGATCCGCTTCTTTTCCAAAAGAACCCATTAAAATATCTTTGGAGGTCATGCCCCAAACCAAGCACGCGGTCATATCACGATAATACGGTAAAAAATAATCTTTTTGAGGATCAAAAGCCATCGCCATCGCTACTTGTGCAACTTCTGCCCCTTGACCAGAAATATTGAAAGAGGTCTTACCAATCCTTGTTAATTGCCACAACCGTTCGTCTAAACGACGTCCTCGTAGTACTTGACGATATGCCTGAATCAATTCTTCTTTTGATAAACCCGATTTTTTAAGCGTTTTCATTTTCATCAACCTTTCTCTATTTGTGAATCGCTAAGCCATAAGTATCTAAGGCTGCTTCTTGCAATACTTCTGTCATTGTTGGATGCGCATGGATTGCTTCACCAATTTCAATGGGCGCGGCATCTAAATACATGGCAGTACTTGCTTCGGCAATTAAATCCGTGACATGTGGCCCAATCATAGAAACCCCTAATAAATCATCGGTCTTCTTGTCACGAATTACTTCTATAAAGCCATCTGTTTCTCCATAAACAAGTGATTTACCATTACCATTAAAATTAAAGGTGCCAATCACTACTTCTTTATCTGCTGGTAAAGTTTCTCTAGTATAGCCGACACTTGCTATTTCAGGATTTGTATAAACACCTCGAGGCACGTTTGTATAATTTAAAGGTTCAACTGTCTCGCCTAAAAGATGCTGAACAGCTAACTCTCCTTCTTTCATAGCCACATGTGCTAGTTGGAGTGTATCGATACAATCACCGATCGCATAAATATGTCCTTCTGTGGTTTGATAAAATTCATTTACTTCAATGCCTTTGTCAGTATATTTCACTGAGGTATTCTGTAACCCTAACTTATTGATATTGGGTTGACGCCCAATTGCTACCATGACTTTGTCAACAGCGAGGCTTTCTTGTCCTGCAACTTCTATTTGAACCTTCTGCCCGGTAACTTTCGCTTCTTGGACTTTGCTACCTAATAAAATGTTAATTCCTCGTTGCTCTAAACGTTTCTTTAATTCTTTAGAAATTGTTGCACTCTCATTTATAAGTAACCGATCCAAAAATTCAATGATAGTTACGTTGACACCTAAACTATTTAATAAAGAAGCCCACTCGACACCAATAACGCCACCACCAATAATTGCAATTGATTCTGGTAGCTCTTCTAATTCAAGCATCCCATCAGAAGATAAGATAAATTCTTCATCTAGTGGCAAATTAGGTAACGTTTTAGGACTAGAACCTGTCGCAATAATGACATTTTTAGGAACGATAATTTCTTCTTCCCGTGTTGGATCATTAAACGTAACTGCCACTGCGCCAGAGACTGGTGAAAAAATGGAGGGACCTAAAATCGCACCTTCGCCTGCTAACATTTTGATTTTATTTTTTTTGCATAAGCCTTCAACACCTTTGTGTAACTGCTCAATAATTCCTTCTTTCCGTTGTTGTATTTTAGAAAAATCAATGGACGCTGCCTCTGTTTCAATCCCAAAAGAAGCCGCTTGTTTTAAGGTATCAAAAACCTCTGCGCTTCTTAATAAAGCTTTTGTAGGGATACAGCCTTTGTGCAAACAAGTGCCACCTAATTTGTATTTTTCAACAATTGTGACGTTTAGCCCTTTTTGTGCGGCTCGAATTGCTGCTACATAGCCTCCTGTTCCGCCACCTAAAATCAGTAAATCTGTTTGTTCCGCCATTTTGATCACTCCTGCTCAATTTTTGCTTCACTATAATTTAAAGCTTGTTCTTCCCCTGTTAATACTCGATTGACGCCTTCATATAAAGCAGCCATCTCCATTTCACCTGGGTAAACCTTAATTGGTGCAATCCAAGTGACTTTTTGACTAATTTCTTGAACAACGGTTTGCGAATAGGCTGCGCCCCCTGTTAAAATAATTGCATCAATTGTGCCTTCAAGAACCACGGCCATCTCGCCAATACTTTTTGCGATTTGGTAACACATTCCTTTTAAATAGTAATTTGCTGTTTGATCACCTGCAGCTATTTGTGCTTGGATATGCCGTAAATCTGTTTCACCTAGGTATGATTTAAGGCCGCTATTACCCGCAATTAGCTTTTTCACTTGGCTAATCGTTAACTCCTGTTCAAGTATCCATTGCGCAAATTCAACGAGCGGTAAGGCACCACTGCGTTCTGGCGTATAAGGACCTTCACCATCAAGCCCATTTACCACATCCACCATGCGGCCTTTTTGATGCGCCCCCAAGCTAATGCCCCCACCTAAATGAACAACGATAAAATTGCTTTGCTCATATGTTTTCCCTAAATCCTCAGCGATTTTTCGAGCGACCGCTTTTTGATTTAAGGCGTGACCAACGCTACGCCGGTGAATGCCTTTTAATCCGGAAATCCTGGCTAATGGTTGTAGCTCATCTACAACAACAGGATCGACAATAAAGGCTGGCACGTGATATTTTTCTGCAAACTCATTAGCTAAAATCGCCCCTAAATTTGAAGCATGGGTATTAAAGCGTTCTGTCCGCAAGTCTTCTAGCATTTGTTGATCGACAAGATACGTACCGCCAGGAATAGGCTTAAGCAAACCACCACGCCCTACGACAGCGGCTAATTGTGTGATGTTATGTGTTTCTAAAAATTCCGCGATCATTTGTTTTCGAAATGGTGTTTGACTGACAACATTTTCAAAAGGTGCCAATTCTTGGACGCTATGTCTAAGCGTTTCTTCCGCCAAGCAATCATGATTAGCAAAAAGCGCTAACTTCGTGGAGGTCGATCCAGGATTAATAACCAATACTGTTTCCATTGTTTTCTGCTCCTTTTTTTAAACTTGTCTCATGGCAAATCTTAATGAATGAAATTTGCTTTCTGTCGAATCACTTCTAGATGTTAAAACGACTGGGACTTTTGTGCCAACAATCGTTCCTCCCACCTTTGCGTGCCCAAACAAGGTTAATGATTTGTATAAACAATTTCCAACATCAATAGTTGGGACCACTAAAATATCTGCATCCCCCATGATAGGACCGCTGTAACGTTTATGCGCAACCGCTTCTTCAGAGGTCGCTAAATCAAGCGAAAGTGGCCCAAAAACCGTAGCCTCTTGTTGATCATTAAAATGTGCCGTGACTTCTTTTGCTAAAACAGACGAAGGCATTTTAGGATTGAAATTTTCCGCTGCGCTTAACAAAGCAATTTTCGGATGATGCAGTCCCAATTTTTGGGCGACTTCTTTAGCATTTTCAACAATTTCAATGAGGGTCGCTTGAGTGGGGGCGATATTCATCGCACAATCGGTTAACAAGAAGGTTTTTCCCGCAGGCAGCTCCACCATTGCTACATGGGAAAGAATCGGTTTATTTTTTAATTGATGCTCACTTTTCAACATTTCTTTTAGTAATGTGTGAGTCTGAATAATTCCTTTCAATAAAATTTGTGCTTGACCGGTTGCAACTAGACTGACAGCTTCCTGTGCTACCGCGGCCTCATCTGAGCAATGAACATATTTCCAGAGATTTTCAGTATCAAGATTTTCATTTGTATCAAATACAATAAACTGCAACGGTTGCTCGGCTTCTTTTAGCGCTTTTTTAACTAGCTGTAAAATCTCTGGTTGTGAACCTCCTGCAATTGAAACAGTGATCATTTTCTCACCTCATTTTTCTTCTTTACACTTTAAATCTACCTCAGTATGTAAGCGCATACAAATTGTTAATTTTTATGTCCTTATTAATATTTTTTATAGAGAAGGAAAAGCTTAGTAAATCAAGCTTTTCTTTCTCTAAACAATTGTTATCTAATTTACTTTTCATGAAAAAACTTCTTTTCTAAGAATGAAAGGAAAACTTATGCTTCGGCACAGCTGTTTATTTATGTCAGATTCTAAAGCATGTTATACTTTAGATACTTATTTTTAGGAGGAATTAAATGGCACTACTACTATTCTTTTTGTTTATCGCCCTACTAGGATTTGGTATATTAAAAATTAATAACCGCAGTATCCTCGGCGGTATCACTCTGGCTTCCGGCACCTTATTGTCATTAGTCACCTTACTATTTATCGGACTAGACAAAATTTATTTACATTTTAAGAATGGCGACCTAATTACCTTGGCCATTGCTTATCTATTAATTCCCGCTGTGTTTATCGGCATTTGCCTTTACTTTATTTTTAACTCACGTACGATGCAAACGAAAGAAGGCAAAAGTGTCACGGCTAAATTGTCGGCGGGCTTAGGGTTGAACTTATTAATTGTTTTACCAGCCTTTCTATATTTATTATCAGTTGGCACAGCGCAAATACCTTATGTGCTTTTTCTGTTCTTACTTTTTCTATTGTTAATGGATCTTTTGCTGACCTTTCTATTTGCTGCTTACGTCTTGTATTCATGGATGTACCAAATGATTCCTTTAAAAAAAGCGGTTGATTATATCATTGTTTTAGGTTCGGGAATTCGTAGCGAGGAAGTACCTCCACTTTTGAAGAGTCGGTTAGATAAAGGGATTGAATATTATGAAAAAAATCCCACCGCTAAATTTGTAGTCAGCGGTGGTCAAGGTCCTGACGAACCTGTGGCCGAAGCTTTCGCAATGAAAAAATATTTGCTTTCACAAAATATTCCTGCAGAAGCAATTTTGATGGAGGACCAATCCACAACCACTTATGAAAATATGTTGTTTTCTAAAGCAATAATTCAGGCAGATTGGCAAAAGATGCCGTCTGATTCTAAACAACCCTCTGTAATTTTTTCAACAAATAACTATCATGTCTTACGAGGAGCTATGTATGCCCATCGTGTCGGCTTAAAAGCTGAAGGTGTCGGGGCGCCAACTGCCTTATATTTTTTACCAACTGCTCTAATCCGAGAATACACTGCCTTACTGGTTCATGATAAGCGAATTGTGCTTTTTGTTTTTCTACTTGTCACTCTTCTTTTAGGAATCAGTATCTTACCCATCTAAAAAAACAGCGACTCACATTTTTGTGAGTCGCTGTTTTTATTCTTTTAATATAAAAAGGTTTAATGAACGTAATTGGCTATCAATGCAATCAGCCATAAATGAAGCGGATAGAATCCGTAAAATAAATATTTGAAAAATGGTGCTTTGCTCCCTCTCTCACCATTGTAAAGCGATATAAATGGTAACACAGTGATAAACATAAAATCAGAATTATAAGCTAACATTTCAATTGTCGTTGGCCAATCTCCCAACCATTGAAAACTTGTAACTAAGAAAAAGAGCGCTAATGCACCATATAAACAGTTCCGTAAGACAAGTCTCTTTCTGGCAAGATACGTAATCAACATAAAAGGTAACATCACAACGCCACCTTCAGCAAACATTGCTCCTATTCCTAAAATGGCTAATATACTAATCAATAAAACAATTTTTAAACTGATTTTTGGCATCTCTAGCATCGCTTTTGTCACAATTAACATACTGACACCAAGGGCTAAGGTGAAGAAAATATTGTTGTGAACAGCGACAGCTGGATTATTCACTAAATGATTTAGAAGCGTATTTCCAACAAACATGATTGCTGCCCAAATATACAAACGACCATTGTAACGATAAATATTCCGTGTATAGTTGAACCCTTCTACAGCCATGTAACCAAAAAACACACCGACACAACGAGTAATTACATGAAAAATCAGTGCCCATTCTGGCGGAACAAAATAACTAATATGGTCAAGAACCATTAACCCCATCATCAATAATTTTAAGCGATTTGCGTTCATGAATCGTCTCCTTTATTTTTTCTACAGAAACTATCATATCTTTTTATATAACAGAAAACAACGAACATTCTTGTTAGATTCAACCATTCTTTTTGTCACTTTTGTTAAACTTGGTACCGCAAAGATAAATCTTCAAATAAATAATGCTGGTATTTAAATTGTTCAAAATGAATTTTTCGAATTTCTTGCTTAATGGCTATTAAGCATTCATCGACCGTCATCAATGATTCTTCTTTCAGAAGCGCCTCTTCTATTAATAATTTGCATTGGCAGTCAATCAATAAAAGTTGACTATAGAATGTGTAAAATGTTTCTTTATTTAATTTTTCAATCAAATTTTTAGCTTGATTCTGCAGCTTTTGATAACATTTGGTCAATTTTTGATAATCCATTAAATCAACTAACTGACCTTGTTTTAACATGTTACTAAAGTCTAAATCCCAAAGCATTTCTTTAGTCGGCTGTTGCAATAAATAATACATAGAATGACTACTAATAATTTCAGTGGTCGGTTCTTCAATTGTTTCATAAAAAGTCACAAAATATTCTCGCTCAATCACAGTAATAATTTCTTCTTCTGAAAGCTCACAATCTTCTAAATTTTGATAGAATATCAATAATTTAATCCGCTCATCTATTTTATTCAGCGAAGCGACTAATTCAGGAAAAAGAACCGACTGACAATTCTCTACTAATTCTCTTGCCTTATTTTGTTCATTTTTATAAAAGCTGTATAACTTTTTCCGCTGTTTTAACGAGTTTAATAAGTTATCGGGTATATTCCAGTAATATTGTTTCTTCATAGCATTCCCACTCTTCTTTTTTATGTACAATTTTACAAAATTGGTCTTAGCCAATTTCGTCTCTAGTTATTCTATCAAAAAAGTGACGCTTTTTTACTGACAATAATTACTCGTTTTACGCCCAAAAAGTGAAAATCTAGCTGTTAAGTAATTATTGGGGCTTGTTTCCCGCGGGCCGAAAAAACTTTTTCCTTTTAAAAGTCCAGAAAAAGACCTACACTAGAGATAGACAAACGTTGGAGGGATTTAAATGGATTTACACTTAACGAATAAATTAGCATTAATTACTGGTTCAACCAAAGGAATTGGCAAAGCAATTGCGATTGAAATGGCTCGCGAAGGGACCGATGTCATTATCAATGGGCGTAATGAAGCCGAAGTAATCAAAGTTGTTGAAGAAATACAAACAATGTTTCCAGACACTCATCCTCAAGCAGGAACTGCCGATATTTCCATTGAAAGTCAACGAACTACTTTGCTTGAAAAATTCCCTAAAGTCGACATTTTAGTGAACAATATGGGGATTTTTGAACCAATGGAATACTGGGACATCGATGACGCCACTTGGGAAAAATTTTTTACTGTGAACGTGTTGTCAGGCAATGCATTAGCAAAAGCTTATCTACCTAAAATGCTTGCACAAGATTTTGGTCGCATTATTTTCATCGCTAGCGAAGAAGCGGTGATGCCTTCTGGCGAAATGCCCCAATATAGCATGACAAAAACGATGAATCTTTCCTTAGCTAAAAGTTTATCCAACTTAACTGTCGGCACACATGTCACCGTTAACACGGTTATGCCTGGCTCAACCCTTACCGAAGGTGTAGAAAAAATGTTGGAAGATATGTACGCTGATTCAGACATTCCCAAAGAGGATTGGGAAAAAGATTTCATGAAAAATCATCGTTCTCGTTCACAAATCCAACGGCTCATTCGTCCAGAAGAAATTGGTCGTTTTGTTACCTTTGTGGCCAGCCCGGATTCTTCTTCCTTCTCAGGCGAAGCCTTAAGAATCGATGGCGGCTTAGTTCCAACGATCTTCTAAATTAAACAAAAAAGACAGCCAGCAAAAATTCACATTTTTTTGCTGGCTGTCTTTTTAAGCATATTAATTGATTACTTACCAAAAGTAAGTTATATTTATCTCGAATTCGAAATAAAAAGAGGTGAAACAATGAACCAACAGCAAGAAGCTTTAAAAGCCTATATCGGTTTATTAAGAACCAGCCATCGACTAGAGCAACTTGCCAAGCAAGATGTTACTTGTTATGACTTAAACATTACAGAATTTTCAGTGTTAGAGCTGTTACTCCATAAAGGTCCTCAGACCATCCAAAAAATCAAGGAGAAAATTTTAATCGCTAGCAGTAGCACCACTTATGTTATTGACCAATTACATAAAAAAGGCTATGTAACGCGCACTCCCAGTGAAAAAGACCGACGCATTACTTACGTCGAATTAACAGAAGCTGGAAAAACATTAATTAAAGAAATTTTCCCGACGCATGCAAAGCGAATTGCAGAAGCATTTGAACAACTCTCTTCCGAAGAATTAACACTTCTTCAAAAAACTTTACGAAAAATAACAAATGAAACGAAATGAGGAAATAATGATGAAAAAAGAAGATCAATTATTAGGAATCCACCACGTTACAGCTATGACAAGTGATGCAGAAAAAAACTATCACTTCTTTACAGATGTTTTAGGGATGCGTTTAGTCAAAAAAACAGTGAATCAAGATGATATCTATACTTACCATACCTATTTTGCTGATGATTTGGGTACACCAGGTACAACCATGACCTTTTTCGATTTTCCCAATAACCCTAAAGGATTAAAAGGAACCAATACAATTTCAAGAACAGGGTTCCGGGTTCCTTCAGATGCAGCTTTGACTTATTATGAAAATCGCTTCAATGAATTTGCTGTCAAACACACAGGTATTTCTGAAGAATTCGGGAAAAAAGTCCTTCGCTTTTGGGATTTTGATGATCAAGCGTATCAATTAATCTCTGATGAATTAAATCAGGGCGTTGCAGCGGGCACCCCTTGGAAAAAAGGACCTGTTCCAACAGAATTTGCGATTTATGGATTAGGACCTGTCGAAATAGCTATTTCCTATTTTCATGAATTCAAAGAAGTCTTTGAAGAAATTCTAGGCTTTCACCTAGTGGCACAAGAAGGCAATCGCTATTTACTAGAAGTTGGCCAAGGTGGCAATGGTGCCCAAGTCGTTTTGGTAGACGATGATACTAGCTCACAAGCGCAACAAGGATATGGTGAAGTACATCACGTTGCATTCCGCCTAGCGGATCGTAAATCACTTGGGACTTGGCAAGCGCTCTTTGATCATTTAGGCTTACAAAACTCTGGCTATGTCGATCGTTATTACTTTGAATCATTGTATGTTCGCATTGGACATATTTTAGTCGAATTAGCCACCGATGAACCAGGGTTTATGGGGGATGAACCTTACGAAACATTAGGAGAAAAGTTATCTCTTGCGCCATTTTTAGAAAACCGTCGTGAGTATATTGAGAGTGTTATCAAGCCTTTCAATACAAAACGAGCCTAAGGAGGAAAAAAAACATGCATTCAATTTTAAAAAAAGGACATCCTGAAGCACCTGTCTTTGTGCTACTTCACGGTACAGGTGGTGATGAAACATCTCTCCTACCAATTGCCCAAGAACTAAATAAACAAGCTACTGTGCTAAGTATTCGTGGTGATGTTTCAGAAAATGGAATGAATCGTTATTTTAAGCGCCTAGCGGAAGGTCATTATGACTTAGAAGATCTAGAAAAACGCGGCGAGGCGCTTCATAAGTTTATTCAACAAGCCGCTAACGAGCATCAATTTTCATTGGATAAAATTATTTTTATTGGCTATTCAAATGGGGCCAATATCGTTATTCAATTATTGCTTACTCATCCCGATAGTTACCATCAAGCTGTCCTCTATCATCCCATGTTTCCTGTTGAATTGACCAATCAACCAGACTTGACCGACACTTCTGTTTTATTATCTCTAGGAGAGCATGACCCGATTGTTCCACTTCCTGAAAGTATGCGTGTGATTCAATTATTTCAGAATCATGGAGCAACCGTACAAGAGGTTTGGACACAAAGTCATCAATTAACTTATCAAGAAATTAAGGAAACACAAACTTGGTTGGCACATCTGTCCTCTTAACAAAAAAGTGGGTCCTAAGTCGAAATGACTTAGGACCCACTTTTTCTATTTTAAGATAACTCACTGTCTGAGCTTCTTTTTATTCTGCCATTTGAACAACTATTTTACCAACTGCATGGTGCGTTTCACTGAGTGCATGTGCATCATAAATCCCTTGTCTAGAAAAAGGGAAAACTTCACCAATAATTGATTTCACTTTTCCAGCTGCCATCAAATCAGCAATTTTTTGTAATTGTTCTCCATTTGGTTGAAGCCAAATACTTTCAGCAGAAACATTTTTTTCGGCTGCCAATTGTTTATCTTCAATGCCCACAATTGAAACAAGACGACCTGTGTTTGGTTTTAAGACGGCAAAACTATTTTTTTGAACCTCACCACCCATTGTATCAAAGACCAAATCAACATCAGCTAATACCTCTGCAAAATTCGTTGTATGATAATCAATCACTTCATCTGCACCAATTTTTTTCAGTAAGGCATGATTTTTGGCGCTAGCGGTCGTGATGACATGTGCGCCCGCTTCTTTTGCTAGTTGAATCGCATAAGTACCGACCCCACCTGCACCAGCATGAATTAAAACAGTTTCTCCTTCTTTAAGGTGACCATGATCAAACAATGCTTGCCAAGCGGTTAAACCAGCCAACGGAACGGCAGCCGCTTCTTCAAAGCTAATTGTTTCAGGGATTTTTGCTAATAAATGATCATCCACAATCGTTACTTCTGCATAGGTACCAAAACGAGTAGTTTCAGGACGAGCAAAAACTTTATCGCCAACTTGCCAATCCGTTACTTGACTCCCCACCTCTGTAATCACACCAGCGACATCCCAACCAAGAATAATCGGAAAGGACCAATCAAACATCTGTTTTAAATATCCTTCACGCAATTTCCAATCAATCGGATTAATTGATGTCACGTATTCTTTTACCAACACTTGATGTTCCGATAATTCTGGCAGTGTTACTTCTGCTTCTTCAAGTACCTCTTTACTTCCGTACTGATTAATCACAACAGCTTTCATAAACCAACTTCCTCTCATTTGTTTCATTTTTCACACTTTTAGTATACGCCTATTGCCTTCTTTTTATATAAGAATATGCTTTAGTTAAATTGAGAGAAAGTAGCTGTTTTTAGTCTATTATTCATAACGTAAAGATTCAATTGGATCTAATTTTGCTGCTCTTCGAGCTGGTAAAGTTCCTGCTAAAAAAGCAATAAACATAATAACTAAGATAATCGTTAGTGAAGATGGCAATGAAAATTGAATTAATTTAAATCCTGTTAAAGCCTTTAAAAAAGAATCCGTTGCCAAACGATTAACTAAATTTCCAACCCCAACAGCTCCTAAAATGCCTAATATTGAGCCAAAAAAGCCAATTAAAGCCGCCTCAACACTAAAAATTGTAAAGACTTTCCCATTGCTAAGTCCCATGGCTTTCATTAAACCAATTTCTCGCGTTCTTTCTTGGACAGACATATACAGCGTGTTAATAATGCCAAAGCTTGCAGCTAACAAGGCAATTGCACCAAACATGGTTAAGACACCAGTGATTGCATTGATTATATTACGAATCATGCCAATTTCATCTTCGACAGTAGTCGCTAAATAGCCAGCTTTGTCTAAATCTTTTTTGATGTCCTTAATCTGCTCTGGCGTGCTGTCTTTTTTAACTTCAGCAATAATCATCGCGTATTGATTTTTTAAATGTTCTGGAAGATCTGCTTGATTGATTGAGACAACTTTATCAATCAATGCTTTATTCATCAGCGAGAGCCCATTTTGAATGACACTGGCATTTCTAACGCCAACAATTTTTGCTTCAATAACTTGCTCTTGTCCTTTCAAGGAACTTGAGATACCTAATTGAACTGTTTCCCCCACGGCAGCTTTACTAGATGTATAGCCGAGCGCTTTTACATATTCTGGTGACAAATTAATTTCGAAGTCCTGGCTCGTTTGCGAAACTTTACGGCCAGCCGCTAAATCAATGGTCATCTCATCTAGCGCAGAAGTTGCTGAAAATACATATTTATGCTTATCTGCTCCTTTTATATAATCGATAGCAACGGATTTCATTGGTTCCACTGATGTAACATCCGAGATTTTTTTAATCTTCTCAATATCTTTTTCAGCAAGCATACTTTGTTGTTGAATCGTACTGGTTTTTTTCTCTGGATTATATTTACTTGGTTCTGTTCCGTTACCAACATTCATCTCCATTTTTGGCTGAATAAATAACTGATTTGCACCACCGACACTGCCGACTTGTTTGTCAATATAATCATTTACACCAATATTGACTCCTGTAGTTAAAGCTATGGTAAATGCTCCAATAAAGATTGCAATAATGGTCAATACGGTTCGACCTTTATTACGCATTAAATTGGTACTAGCTGATTTTAAAATATCTCTAAATTTCATTTACTCATCTCCTCCTACAATCAAGCCGTCTCGAACATGAACTTGCCGATCACAACGTGCTGCTAAGTCTGGATCATGTGTCACAATAATTAAGGTAATTCCTTTATTTTTATTTAAATCAAATAACAATTCTTCAATTTTCTTCCCAGTGGCAGAATCTAAATTCCCTGTAGGTTCATCTGCAAAAATAATTTGCGGATTATTAACTAAAGCACGCGCTATACATACCCGTTGTTTTTGGCCACCAGATAAATTATTCGCTTTATTTTGAACTTTATCTTCCAAACCGACTGCTTTTAACGCATCTAAAGCCATCTTTTTCCTCTTGCTACCGGAAATCCCACCAATTTTTAATGGTAAAAGAACATTATTTAAAACTGTATCCTTGGCATTCATAAAGAATTGTTGAAAAACAAAACCAAATTCTTCATTTCTCGTTTTATTCAGCACTTTCTTTCTAATACTAGTAACATTTTTACCATTTAAATAAATATCTCCTGAAGTTGGTTGATCTAACAATGCCAAAATGTGCATAAATGTTGATTTCCCAGAGCCACTTTTACCAATTATGGCCACAGATTCACCTTTTTCAACTTTTAAATCAACACCTTTTAACGCATCAAATTTTGTTTCGTTCTTTCCATAACTTTTTTTGATATTTTTTGCTTCAATTACCGCCATGTTACCCCTCCATTTTTCATTCTTTGTCGTTTACTTATTTACAAAGTTTTTTACTCTTTTCATACTCCTTTCTTCTCTTTCTATTTTGACGGAAGCCCTTTCCTTTGTCATGGTAATTCCGATGTATCTCTCAATTAAAACAATAAGAACATGTTCCAAATTCACCTCATTGAACATGTTCTTATTAATTAGTTATGCATTTACGCGTTTAATTTCACGATGTTTATTCAATAAATAGGCCAAACCAAGATTAATGCCAACAAAGCAACTGATTGTCAGAAGAAGTGGTAGGACAGTAAAACCAGTGGATTGATAACCAACCATTGCTTGCAAGACATGGAGCATTCTCAGGCGCATTGGTGCCCCCCCTAATTGTGCAATCGTGCCCAGTAAAATAGGAATCATTAATAACAGCAATAAAACAATGAGTTTTTTTACGCCATCTATCCGATCATTAAAGACACCTGCTAACAAGCCAAGTGAGCCGCTAAGCATTAGTAAGATAAAAAAGAGCAACCACGACATGAAAAAGTTTCCTTGCGCATAGACATCAATTAATTTCATTGATAATTGAAAATGAGAAATGAAATTGCCGCTAAATACTTTAATCAGTACAAGTACAGCCAAGGATCCAACCAAAGATAAAATAGCATTACTTACAAAATTCACCAAAAAAATTGTCCAGCGGGAAAGCCCGTTTTGAATAAACAGTTTAAAATCTGTGTTCATTCCCAAAAATGATAGTATCCCCATAAAAACCAGACAAGGAATTACTGCATCAGAGCTGACAGTATTCACGTCGTTAGAAAAGAGCAACCCAATAAGAGGAAAAAGAATGCCGAACAAAGCATAAAAGCCAAAATAAATTGCTAAGGAACGGACTTGATAAATAACACGATACCGCAAAGCTGTTTTAAATTTCATTTTACTTTTCCTTCTTTCTATTGGTTAATTGCACAAAATATGTTTGTAAATTTAGCGGCGCAATTTGAACCTCTGCTTTTTCAGTCGGCAAGTCGCCGTACACGTAAGCCGTAACTGCCCCACCTAAAGTGTCCATGCCTAAGATTTCCAATGACTGAGTATAGCGCTCTACTTGTTCTTTCGGCCCAGAAACAATGCGACCGTTTTTCAAAATTGTTTCAATAGATTCTGCGCGAATCAATTTTCCTTGATCAATGATGATAATATCTTCTAATAAATTCGCAATTTCTTCAATCAAATGGGTGGAAATCACAAACGTACGGGGACGTTCTTGGTATGTCTCAATTAAATAAGTATAAAATAATTCCCGATGATTGGCGTCTAAACCTAAGACTGGCTCATCTAAAAAAATATACTCACAGGGGACGGATAGCGCCACTATTAGTTTAGCAATACTCCGATAACCAGTTGATAATTTTTTGAATGTCTTTTTACCATCTAAACCAAAATCGCTTAACATTTGTTCGGCTAAAGACCAGTCAAAGGATCCATAAAAACCTTCAGTCGTTTTAAAAATATCTTTAATTTTTAACTGAGGAGGAAATAAATTATCTTCACTCATTAAGTAAATATGATTCAAAGCAGTCTCATTATCGGTCACTGTTTCTCCCGCCAATTGAACGGAACCTGAAGTGGCAAAACTTCGATTATTAATGATATTTAATAACGTACTTTTACCAGCCCCGTTTCTGCCTAAGAGCCCATAAATCGTTTCTTTTTCAAAAGTAATTGAAATATTATCTAGTGCTTTTTTTTGATGATATTTTTTACTTACTGATTCCACCCGCAAACTCATGCGTCATACCCTCTTTCAATTAGTTGTTTTAATTGTTCAGCTGTAATTCCTAATTTTTTAGCTTCTGCGACAACTTCTAAGACTTCTTTATTTAAAAATTCTTCTTTCCGTGCACTTCTTACTCTCTCTTGAGCGCCTGGTAAAACAAACATGCCAATCCCCCGTTTCTTTTCAATCAACTGTCGTTCTACTAATAAATTCATTCCTTTTAAAACGGTGGCTGGATTGATTTGATAACTTTTTGATATTTCTGTGGTTGAGGGAATTTGTTCGCCTTCTAAGTAAGCGCCATTAAAAATTCCTTCGGCAATCTGATCGGCTACTTGCTGAAATAAAGGCTTTTCCCCCGAAAAATTAAATTCCATTTTTACACCTCGCTTAAATAGTTAACTACTTATGTAACTAACTATATATCCTAGAAATTCTTTTGTCAATAAAAAAACCATTGTTTCCAAAGAAATTTTTCTTTGGAAACAATGGTGATACTTTTGAGTTTATTGAATGATTTCGTTCTTATAGGGTTCCATTGTATAACAATTCATCGGTTGTTTCGTTGACAATTTTTAAGCGATTTTGTTTTTTTATCAAAATACTTTTATAGGTCGTTCCTGTAGCCTTTTCTTCCATCACAAGAATGCGTTTATACTCATTATCAGTGACTTTCTTAATCGTTGTTTGATTTAAGGACGGAATTTTTTCTTTTAGCGTTTTTTCTTCCGCCAGACCTTTTAAGATTTCTGATTCTGTAGTGGAACTTGTGGGTTTATTAGAATCGCTTGATACACCTTCGTTATTAGACGCACTTTCAGATGACTTGCGACTTGATTCAGTTACTTTAGGCTGTGATGATTCACTGGTATTGGTTGAATTCATTTGAGTTTGGGTTTGATTCCCACATGCACCAATTAGCAACCCAACGCCTAAGATAGAACTTGCTAAAATTGTTTTTCTAATCATTTGCATGACCTCCTACATCTATCATTACTTTAACCTTAACATTTTTCAGCTAAGAGAACAATTTTTCAGATTAGAAAAGACCACTAGTCGTTATTTAAATAAACGAACTAGTGGTCTTACTTATTTAGGAATGATCTTCATATGAGTGAGTGGGTAATAAACAAATTGTGCTTTCCCTAAGATTTGATCTGCATGTATTGCACCAAAAGAACGGCTGTCTTTGGACATACGGCGATTATCACCAAGCACAAAATAGCTATCTTTAGGTAATTTTTCTTGCATTAACAATTCTTTTGAATCAAAATTCGTAGTATAAGGCATCGTTTCATGATCTTTTTTTCTGTTTTTAGTTAAATACGGTTCAGCGATTGGCTGATTATTGACATATAATTGATCGTTTTCGTAACGCACAGCTTCTCCTGGTAAACCAATCACACGTTTAATCAGAATCGATCCTGTGTCTGTTTTAAAGACCACCACATCAAACCGTTTAATGGCGGAGAATTTTTCCATCACAATCATATCTCCTTGATTCAAGGTTTTTTGCATAGAATGGCCATCCACCCGAACAGGAATCAGGAAAAATCCTCTTAAAATAAAAACGGCTACGATTGCTGGTACTAAAATTTTCAGAAAGTACATTAAATACCCAACATAATCACGTTTCTTCTTCAACTTCGTGCCACCTTTTTTCTAGTTTTTTTGAATTTCTTTGACTGCTGTATCGTAGGCAGCGTCATTTTCAAGAATTAATTTACCTAAAGTGGCTTCAATTTTTGTGGCTGTTTCATTGTCGATTTCTCCAGTTACAGGCAAGCCATTTTTCTGTTGAAGATCGCTAACCGCTGCTTTTGTTTCTGCGGTGTAGTTTGCATTGTTTTCATCAATAGGATACGCTAATACAGCTAAAATAGCATTTAAGTTCTGAATATCTTCAGATTGATCTCCTTCTTTTAGCGTTTTATCGCGAGGAATCAATTTTAAATAGGCATACTCGGGGTAATCAGCTTTGATGGTTGGTTCAATTCCTTTTTCGTTGATCCATTCACCTTTTGGTGTTAACCATTTTAAAACAGTCAATTTTATTTCGGTTTGGTCATTTAAATCTTTCACCGTTTGGACCGTTCCTTTGCCAAATGTTTTCGTTCCAATTAGTGGGACATTCGCAGATTCATGCAGTGCTGCAGCAAAAATTTCGGATGCACTGGCACTATTGCCATCAATGATAACTGCAACAGGTTCTTTTACTTTAAAGCCGCCGTCTAATTCTTTGGAAGCAACTTCTTTCATCGTACGTCCTTTTTTGTCTTCAAATTGAACAATTGTTTCGCCATTTTTTAAAAACATACTGGCCATTCGCTCTGCTTGATCTAGCAGTCCACCAGGATTTTGGCGTACATCAATTACAAAGGATTTAGCTCCTTTTTTACGTAAATTCGTGATTGTTTCTTTCAATTCTTGATATGTTTTTTTACCAAAGGACGTAATTTTAATCGAGCCAATTTGTGCATCTTTTTTGTCTAACTCACCTGTCACTGTTTTAACGGGAATTTTCCCACGTTTGATTGAGATATTTTTAGTTTCTCCCTCTCTTTGGATTGTCAATTCAACGGAAGTTCCTTTTTTACCTCGGACTTTTGAGACGACTTCTGCTAGTTTCATCCCTTTTGTAGCTGTACCATCAACTTTTTCAATAATATCGCCTTCTTTGATTCCCGCTTTTTCAGCTGGGGAATCTGCTACAGGGGCCTCTGCTACAACTGGTTCGCCATCTTTCATTGTCATAGTGGCACCAATTCCTTCAAAATTGCCAGATAAGCTTTCATTTAAATCATTGGCAGCAGATTCATTTAGATAAGTTGAGTATGGGTCTCCAATGGCTTCAGACATGCCTTTTAAGGCGCCTTCAACTAATTCATTTTTATCTACTTCACCTACATAATTGGTACTAATTTCATTATATAAATCCTGCACTTTGCTTAAATCAGCATTGGTAATTGCCCCTTCTTGACTCATCTTTTTAACACGATGATCAAAATAAATATAACTACTTCCTCCAGCTAAAAATGCGACACAGAGGAGCGAAATAATATATTGATAAAAAGGAACAGTTCGTTTGTTCTTCATAGATTTCATCTCATTTCTAACAAATTCGTCACTACTTTTGTTTACTATAACATGAATGAAAAAAGAGGAAAAGCTTTGTTTGCTTTTCCTCTGGATTTATTTATTGTTTTCAAGGTACTTTTCCCATAACTCATCAAAGATGTCCATGTTGCTTAAATAGTCAGCATTCATTTCTAAATAAGAAGAAAGTTCATGATAATCCTCGGTTTGTTTTGGAAACTGAATATCTTTGGCCGCTTCATTGGCAAAATCAGTTTCAGGATCTTTAGCCGGACCTTTTAATGTCATTAAGTAATGGTAAAAGCTTCGTCTCATGTAAATTAATCACTCCATTTTTCTTCGATAAATTCACTTCTACGTTGATGGGACAATCCATAACGCAAAGCGTCTTTTTTATAAAAGTCTTGATGGTATTCTTCAGCAGGATAAAATGGTGCTGCTGGTTCGATGGTGGTAACAATTGGTTCTGTAAAACGACCACTATTAGCTAGACGTTCTTTACTTTTCTCAGCAATTTCTTTTTGTTCTTGGGAACGATAAAAAATAACTGGCCGATAATTATCGCCGCGGTCTTGAAACTGACCGAAAGCATCAGTAGGATCTGTTTGTTGCCAATAAATATCCACTAATTGTTCGTAAGAAATAATCGCTGGATCAAAAGTGATTTCTACTGCTTCCGTATGGCCTGTTGTGTGTGTTAGAACCTGTTCATATGTTGGATTAGGCACGTGCCCACCTGTATAACCCGAAACAACTGAGATAATCCCTGGTTGTGTATCAAAAGGCTGCACCATACACCAGAAACAGCCGCCTGCAAAAATTGCTTTTTCTTCCATCTCTAACACTCCTTTTTTATTTCTCTTTTGGCAAGTATATATTCATCCGAATGTCATCGTCAACTAAATTAATCTTTTCTGCTCGAACAAATAGACCATTTTGCATTCTAAACTGATCTAAACGTAATAAAACAGTTTGATCATCTGGATTGATTTCAACCCATTTAGGTAGTTTGTAAGAACGTTTAGCAAATTTCAATACTTCTTTAATTGGCAAGCCTAACGTTCCTATAGATAAACTTTTTGCTTTTAATTGTACATTACCATTCGCCATCACGTAAGGATCAAAATATAAGTAAAAAGGAATGTCATGCCCTAACACCTGAAATGTTCCATTTAATAAAGCATCATTTTCTAAATAAAATTTATATTTAATCTCCGAGCCTTTTTGAAAGTCGGCTAAATAAAAGTCAATCAGTTTGTTCACTTGTTGTTTTTTTGACTGAATGGTGACGACTGGCTCGCCTTCTTTTTCAACAATTGCTGGTATTTTCTTTAAATCTGGTTCGCGAACTTGTGTTGCTCGAAATGTCACGAAAGCTACACTACCAATGACTAAACCCACTAGAACAAGAAAAGCGATTTTCCAGGGATTTCGTTTAAGATTGGTTGGTTGTGTCTTTTTAATTGATTTACTTGTTTTTGGCTTTTCTTCATTCATTTTATTCACTACCTTCTGATTTGGTTATCCATTCTTTCTCTGTCTTGACCATTTCATCCCGGACAGCTCCGGCCATAATTTGGTAGCCAAGATTATTCGGATGGAAGCGATCTTCTTCATATAACAAATTGTTTAAATCCTCTTTGCTAGCACTACTTCCTGTAGTTTCTGAGTCACCACCAGTTACGCCAACTTCATCGCCACGACCTTTATAGAGTAAATCATTGATAGGAATGAAATAGGCTCGTTTTTGCTCTTGAACCATTTCTTCGGTTGCTTGATTCCAGTTATCAACGATTTCTTGCATTTCTGTAATTTCGGAAAAGTTTAAGTAGAAGGGATTGTAAATTCCTAAGACATAAATAGGGGCCTTCTCGTTGTACTCTCGGATTTCTTCAAGTAGTCGTCTTACTCGGCGTTGATAGGCTTTTTGTGGACGATTGAACGAGCTGACTTTCAAGTCGAAAATATTACTACTAATTACTTTCATTAAGTCATTTCCGCCAACCGTTAGCGTAATCACGTCCGCAGAGGCAAGGCCTTTTTGAATTTCAGGTTTTTCTTTGATTCGTTTTAAAATTTGATCACTACGATCCCCATTTTTCCCAAAATTGTCTGTTTGAACACCGTTCAAGTTGTAGTGTTCTTTTAAATCATCTGCCACAATAGGAACAAAACCTCCACTATTCGTCAAATCGCCAATTCCTTCAGTTAAAGAATCACCGATTGCTGTATAATGAATGACTTCTTTTTGATTTTTTTGAGCAGTTGTGGCCACTTTCTCTTGCTTTAATAGTGGCTTTGCTTTGGGGATGGCCACACTTAACAATGTAAAAACACCTAGCGCAATGAGGATAGGTGTTAAGACGGTCAGCAAAATATGCTGTGTTTGTTTTTTCATCTTCGTCACTTCCTTTTAAATAAACCAACAAGAAATTTTCCTTTTCTTGTTAGAAAGAGGTTGCGTCTACTCATTTAAGAGTGAGACCCAACCTCGTTATTTCTTAGTCTGTATAGTACATAATAGCAAAGGCATTTTTTCCTGTATGTGTTGCAATGACTGGATTCGTATGTAATACGGGAATATCCATGTCTTTAAAGATTGCTTGTAATCCTTCTTTGAATCCATTTGCTAGTTCTAGCCCATCCGCATGAGAAATGCCAATTTGTCGAACATTTGGAATCTTACTTAATTCTGATTTCAATTCGTCAAACCATTTATTAAACGTTTTAACGCCGCGGCCTTTCGCTACAGGAATCAATTCCGTATTTTCAAAGTCCATGACAACTTTCATATTAAAAATGTTTGATAATAATCCTGTTGTACGGCTGATTCGTCCACCTTTAACCAAATTATCCAATGTTGAAATGCCGATGTATAATTTGGTATTTTGTTTGACGCGTTCAATTTCAGCTAAAATTTCTGGAACACCCGCTCCCGCTTGTGCCAATTTTGCTGCTTGAATGACTTGGAAAGACAAACCTTGGTCTGTAAAATCGCTATCAATCACCGTTACTTTACTTGATGATAAATTGCTAGCTTGACGGGCCGCTTCAACCGTTCCACTTAAGCCTTTTGTCATGTGAATCGAAATTACTTCACTGCCATCTTCACCTAAGCGATCATATAATTCTACAAATTCACCAATTGGTGGTTGACTCGTTTTGGGTAAGGCCTTCGCATTAGCCATCATGTCCATAAATTTTTCGCCTGGCAAATGATCATCATCTGGATAAACAACGCCATCAACCATAATTGATAAAGGCATCATATGGATATTTAATTCATCTCTAAGACTTTTTTCCATCGTACATGAAGAATCCGTTACGATTTTAACGTTTGTCATAAATTTATCACTCTTTCTTTAAAAGGAACCTGTTTTCATGGTAGAATACCATTAAACGGTTAATTATCTAGTTATAGTATAACAGACACTGCCGAATTTTTCATCAAATTAAAATAAAGGAAGTGAATTTATTGGAAAAAACGCATTTCTCAAAAAAATACCTAATCGTGAACGAAGTCTTGAATGCAGTTACACATGGCATAGGCGCAGGTTTAAGTATTGCTGGCTTAGTCATTTTACTTGTTAAAGGAGCTCGTTTAGGCTCACCGATTCACGTGGTATCTTATGCTATTTATGGCTCCATGTTGATTCTACTTTTTTTATCTTCAACGTTATTTCATAGTTTAATTTTTACAAGAGCCAAAAAGGTCTTTCAGGTCTTCGATCATAGTTCTATTTTCTTATTGATTGCTGGCAGCTATACGCCGTTTTGCTTAATTAGTATTGGCGGTTGGTTAGGTTGGACCTTATTTAGTTTAGTCTGGTTAATCGCCATCGTCGGTATTGTCTATAAATCCCTCACGTTGCATAAACAAGAAACAGTGAAAAACATTTCAACGATTATTTATATTGTTTTAGGTTGGCTCTGTATCATCGCTGCTCGTCCGTTATATGAATCTCTTGGGTTTACAGGAACAGCGTTATTGGTCGCAGGGGGTGTGTCTTACACATTAGGTGCAGCCTTCTATTCATTGAAAAATGTGCGGTTTATGCATGTGGTTTGGCATTTGTTCGTCATGCTTGCAGCGATCCTCATGTATTTTTCTGTTCTCTTTTATACGTAATCACAGCACAATAAGAACACGATGCTCAAAGCATCGTGTTCTTTTATTGCCCTAAATCTCTTTATTATAAAGGATTATTCTTCTTTTCGAATTATTTTAACATAAATTAGTAGAAAAGACTTTACAAAACGAACATACATTCGTATAATAACAATACGAACACTCGTTCGAATCAAATGAAGAGGTGATACACATGGAAGCAATTCGTCGTGTTGGATTTTTATTTTTTGTATTGGTTATAGGTATTTTTTTGGGAACATTAGGATTACGTCTTGCTTTTATGATCGTGACGCCGTTATTTATTCTTTGGTTTATGTCATGGGATGAGAAGCGTTATACACGTACACGTAAACAACAGCAAGCAAGATACGTTTATCGTAAGTTCCCTTAATAAATAATAAAACGGTGTGTTCCCCCCAAGCTACGCTCCGTTTTTATAAATATGTCAAAGAAAGAGCGAAGGATTAAATCCTTCGCTCTTTCTAATTAAATTAGATTAGTATTCCATTAAGGTAACAATATCGTAGCCATCAATTTTATCGCGGCCATGTAAATCCATTAATTCAATTAGGAACGCACAACCAACCACAATACCACCTAATTGTTCGACTAATTCGATGGTTGCTTTAATTGTACCACCAGTTGCTAACAAGTCATCACAAATCAAAACACGTTGGCCTGGTGTGATGGCATCTTTGTGCAACGTTAATGTATCTGAACCATATTCTAAGTCATAAGTCACTTCGATGGTTTCACGAGGAAGTTTTCCTTTTTTACGAACCGGAGCAAAGCCAACCCCTAGTTCATAAGCCACTGGACAGCCGACAATAAAGCCACGAGCTTCCGGTCCTACAACCATATCAATTCTTTTTTCTTTCGCGTAATCCACGATTTGTTTCGTTGCTTCACGATAGGCATCCCCATTAGCCATTAATGGAGAAATGTCACGGAACACGATCCCTTTCTCAGGATAATCTGGAATGCTTGCAATGTAATCTCTTAAATCCATTTTTATTTGTCCTCCTCATTCCACAGCCATTGTTGTATTGTTTGACAATCACTGTAAAGTAGAAATTCTTCTGTTTTTATTTTTTTCAATCGTTGTTGGTACACTTGACTTTCAGTCAATGGTCGATTGTCGGGTTTCTCAATACTGTTTAAAACACCGCTTTCTATTGTAACAAATCCTAAGTCAAAAAACACCTGTATCATGAAAATTAATAATTTTTCTTGGATATTTAAGTAATTTGCCACCTTCGATAGCTGGGAACGTAGATTTACTTCTTTTTGCTGCAAAATAAATTTATACAATGTTGCAAATTGTTCACGTGAAGCCATACCGTTTAAATAAGCTTCTTCTGGTGAAATAAACATCATGTATATACGTTGTATCTCAGTCGCTTCAACAATTTCTTTAACCGTGATTGCTTCCACAGGACAGTCGACAAAAACCAGTTGTTCGATTTGATTTTGAGAGACAGCTTCCACCAATTCTTCTTGGTTTGCCCAAACAATAATATTAGCGGTTGGATCTGAAATGAATTTTTGATTTTTTTCATCAAACAAAAGATAAGCTGTTGCTTCTGAAGGAATTGGTTTCGTTTGATTATTTTTGCCACGAAAATCAAATAATTGTCTTCCCAATACAGCAAAATCAGTCACCATTAATTGTGGTTTCTTACGACCATTCCATTCATTGATGGAAAGTTGGCCTGCCACATCGGCGGTTCCTTGTGCTAGTTCATCCGCTTGAGGCCCCATTTGAAAAGCAATTGCATCCAATTGTGCCCCTTCTTGATTCATTTGAAATTTCAGATGTGCATTATCTGCACCAATTTGCCGAATTTGCGTAGGCGTGATTTCCTTAAATACAAAAGTTGGAACAGTATTATCGGTCCCAAAAGGCGCCAAAATACGCAATTGATCAATAAAAGTAGTCGTGGCCTGCGAAACCGCTAAGCTCTCACTAATGAGCAACTCTTGTCCATTAGCCATATCAATTTGATTTTTTTCAATAAAGTGTGCCAAATGTTCTTGAACAAAAGGAATATTTTCAACAGGTAAAGTCATTCCCGCTGCCATATGATGCCCACCAAAATGAGTGAATTGCTCACGCACTTCGTTCAACGCCTCATAGAGATTCAATGCGCTAATGCTACGTCCAGAGCCTTTAGCGGTCGTACCAGATTCATCTATTGCTAAAATAATGGTTGGTTTCCCCGTTTCTTGCATAATGCGGCCCGCGACAATCCCTAAGACGCCTTCATGCCAGCCTTGTTTCGCTAAAATATGGACCGGCGCATTCGGGTCGATTAAATCCAGGGCTTCTTTGGCAATCGTCGTTACAATGTCTTTTCGTTCATTGTTTTGTTGATCAATATATTTAGCGATTTCCAGCGCTTGCTCTTCATCAAATGTAGTCATTAATTCAACACCTGGTGCGGCTTCCCCTAATCGACCTAACGCATTTAAACGAGGTCCGATGGTAAAGCCAATTGATTCTTCTGAAACAGCTTCCTTTTTCACACCCGCTTCTTGTAGTAAAACGTCTAAACCAATTCGATCACCAGTTTGAATCATTTGAAGGCCCATTTTGACAAACGTTCTATTTTCATCGGTTAATGAAACCAAGTCAGCAATTGTCCCAATTGCTACCAAATCTAATAACTCAATTGGCAATTCACCAAGTAACGCAGTAGCGACTTTGAAAGCCACGCCAACACCAGCTAAATCTCCAAAAGGATAGTCTCCTTGCGGATGTCTAGGGTGGACAATCGCATAGGCTTCTGGTAATTGTTCAGGCAATTCATGATGGTCAGTAACGATTACATCTACCCCTTGAGCCATAGCGTAGTTAATTGCTTCATGTCCAGCTACACCATTATCAACGGTTACAATTAATTGGACTCCTTGTTCAATTTGTTCAGCAAATACGTCTTTATTAGGCCCATATCCATGAACAAAACGATTCGGTAGAAAGTACTGAACCATGCCACCGACTAATTCGATTGCTTCTTTCATAACCGTGGTACTAGTGATGCCATCTGCATCATAATCCCCATAGACAAGGATTTGTTCACCCGCTTCGACGGCTTGCTGGATGCGGGCTACCGCTTTCTCCATATCATGCATTAAGAACGGATCATAAATATCTTCGATAGTCGGATGTAGAAACTTACGTAATGCTTCTTCTGTCCGGATATTGCGGTGCCATAAAAGTTGGCCAATTAATGGATTAATTTGTTCTTTTTTTAATTGTTCTATAAATTCTACAGGTAATTCTGTCTTTGTCTGTAACTGCCATTGATAGTTTGATTTTTTCACGACGTCACTCCTAACCAAGTAATTATAGCAAAATTTTTCCAAAAACTAAAGAAAGCATTTTTTTAAATCTGAGAAAAAAACTGTGATATCTGTTAGATAAATAGCAGATATCACAGTTTTATTTTAAAAGAAACTTAGTGATAAAGTCTCTTCCTTATTTTTGTTCCTCTTCATTCACACGAGGTTTCACATAACGATCAATACGACTACCTGACACAGGCGTTGCGTCTACTTCTGTGTTTGATGTTTGTTCGTTGACCACTGGTTCTGCGACTTGTGGTGCTGCCGCTTGTTTGGCTTGCAAATCAGCCAATTGATTATCAAAAGAACGTTGAACTTTTTCCGTTTCTTCTTTGACTAATTTATCCATATCATTTTTATAAATATCCAACTCTTTTTGTACAGCTTTTAATTCCTTACGTTGGTTCCAAATAGTGGTTGTGGAGGTTAGTAACCCAACTAGTGCGCCAATAATTGCAGAACCTAAAATAATTAAGATTAACGGTCCACTAATTTTAGTAAAACCAAAGTTTACTGGAACAGCTTGATTATTTAAAACAGCAAAAATAACAACAATTAAGACCAACACAAGGCCCAAAATAACACGCCATTGATTTTTCATGACTTGATCGACTCCTTTATTTTTTATTTAAAATATTTCCCGCTATGAAATCTCCTAAATGTGGAAACAATGTATAAAAGCGGGCAGCCGCTTCCATGACAAATGGACGATTAATCTCACGTCGAGAAGTCCCCATACTCCCAACCACTTCTTTCGCTAATTTCGTAGGGTCCAAAACAATTTTATCCACCGCAGCTAGATATGTGCCTGTCGGGTCCGCTTTATCAAAGAATTCTGTTTGGATTGGTCCTGGATTGACAGTCGTTACTGCTACACCCAACGGTTTCAATTCTAAACGTAAAGCATTTGAAAAACCTAACACAGCAAATTTCGTTGCAGAATAAACGGTTGATTTAGCTGTAGCCATCTTCCCAGCCATTGAAGCAACGTTGATAATATGTCCTTGCCCAGCTTCAATCATTTTAATAGCTACTTTTTGAGTAAACGTCATCATTCCTAGAACGTTGACATCAAACATTTGGCGTGCAACAGCCAAGTCAATTTCAACAAAATTTTCAAACAAGCCAAAACCAGCATTGTTGACTAAAACATCTATAGGACCAACTTCTGCTGAAATAGCTTCAACCACACGTTCAACACTTTCTGGATCGGCAATATCTAATTGATAAGAAAATGCTTCTCGTCCGCTTAAAACAGCACACTGCTCGCGAACTTTACCAATCAAATTAATTCTGCGGGCGCAGACAACGACGACCGCCCCTTGTTTAGCTGCTTCATAACAAATTTGTTCACCTAAACCAGCTGAACCTCCAGTTACGACAACGACTTTATTTGTTAAATCCATCTAAGCTCCTCCTTCATTGGCAAATGGAATCTCAATGATATCCATATCTTTTACGATTTTTGTATTGGGGAAAATTTCTTGGGCTTCTTCTTGAAGCTGATAGGCCTCTTTGGTTAAATAACGGGCACTAATATGCGTTAAGATAAGTTGTTTTACTTGCGCTTCTTTTGCAACTTCAGCTGCTTGTTGACTGGTTGAGTGGAAGTAGGCTTTTGCCATTTTTGCTTCGTGTTTATTAAACGTACTTTCATGGACTAAAACATCCGCTCGTCGTGCTAAGGTTACGCTATTTTTGGTTTTGCGAGTGTCTCCTAAAATCGTCACGATTCGTCCAGGTTTACGCTCTCCCACAAACGCTTGTCCATTAATTTCCTGTCCATCAAAAACAATCGTTTCACCACGTTTGAGTTTGCCATACAACGGCCCAGAAGGAATCCCTAAAGCTTGAAGTTTCTCTACTTGTAATTCTCCTTCATGCGCTGCTTCCTCAATTCGATAGCCAAAGCTCGTGATGCCATGGTCCAAGATATTACAGCGAACAGTGAATTGTTTATCTTTAAAAATAACGTCATTTTCTTTCGTTAATTCAATAAATTTCAGTGGATAGGACAACCGCGATTGCGAGACCCGTAAAGAAGTCTTGACAAAGTCAGCAATCCCAACTGGTCCATAGATTTCTAAAGGTTCTGTCCCGCCCTGAAAAGAACGACTACTTAACAAACCAGGTAAACCAAAAATATGATCCCCATGTAAATGTGTAATAAAAATCTTTTCAATTTTTCTTGGGCGAATACTACTTTTTAAAATTTGCAATTGAGTCCCTTCACCACAATCGAAGAGCCAAACTGCATTTCGTTCATCTAATAATTTCAACGCAATCCCTGTTACATTGCGATGTTTTGCTGGTACACCAGCGCCTGTTCCTAAAAATTGTATTTCCATCTGCTACCATACTTTCTTTTAAACTTCCTTTTTATTTTAGAAGAAGTTTGCTCCTTTAGCAAATAATAATTTATCTATTTTCTCAAAGTTTTCTTCTTAGTTTACCGCATTTTACGATAAAATAACAAAAAATTAACAAACTACCATAAAAAACCGTGATTTCTTAGTATTTTAAAAGACTGTTTCCCTTTATTCAGAAAACAGTCTTTGCTCCTTATTCTTCTTTCGATGTCGCTTCTTTGTGTTGTTCTTTTTTTGCTTGCCACGATTGTTTCGCTTCATTTGCAACTTCGTTCGCATCGTTAATTTCTTGTTGGACTTCCTCTAAATCAAGCCGCGTGATTTCGCCACCTAAGTCAAACATAACCAATTGGTTGAGCGGACGATTGTCTTCTTCTTCTGCAATTAATAATAATCCCGTTTGTCCTTCATCAATCTTTTGAATCACATGTTCAAAAACCGTTTGTGCTTCTTGAATTTCTTTGGCATCTTTGCTTGCACCATACATACTTCCAGCAAACCAGCCAAAAAGAATGCCCAGAGGACCACCTAATATGCCTACTAGCATCCCAATCATGCTATCTTTTGATGTATGATTGTTGCCTGTAAAATCGATAAAATCATTGATTTTAAATTGATGCTGGCCATCATTAACATGCGTAACAACCGCCATTTGCTCACCTTTAAGCTGTCTTTCTGCCTGCATCTTTTTTATTTCGGAAAATGCTTGGTACGATTTACTTTCAATATCAAAGTTCATAATGATAATTCGTTTTGTCATACAAATCGCTCCTTTATTCTGGATACATCTATTTTAGCAAGAAAGGCTTGTCTCTAGCAATGAAAACTTTTTGGTTATGTATAAAAAAAGAAGATAGCTAGGCTACCTCCTTGTTAATGCTTATTTACCATCAAGAATATTTAAACGGACCTTTTTCGGACCATCGATACGTACACTATAAACAATTGTCCGAATTGCTTTTGCAACACGCCCTTGTTTACCAATGATACGTCCAATATCTTCTTTGGCCACAGTCAAATTATACTCGAGGAAATCAGTTGATTCCTCAATTTCTAATGAGACTGCTTCAGGTTGACTGACTAACGGACGGACAATAGTTAAAATTAACTCTTTCACATCTGCCATATTCAATCACCTTATTTCTTAACGTTTTTAGCTTCATGATGTTTTTTCATAACGCCTTCTTTTGAAAGGATGTTACGAACTGTATCAGAAGGTTGCGCACCTTTAGATAACCAATCTAAAACTAAATCTTCTTTTAAAACTACTTCTGCAGGGTCTTTCAAAGGGTTGTAAGTACCTACAGTTTCGATGAAACGTCCATCACGAGGAGAACGAGAATCAGCTACTACAATACGGTAAAAAGGACTCTTTTTAGAACCCATACGTTTTAAACGAATTTTAACTGCCATTATTAAATACACCTCCATTAACTTAATCACAAGAGTTAGTTTAACAGATTAACAACAACCTGTAAAGAGTTTTTTCTTGACACCTTTACTTTTTTTCAATTTTTTTAGCCAATTTGCAGGAAAACAAACGAAATAATGAAGAATTTTTACAAAATTTGATAATAGTTGTACTGGTTTCTCACTTGAAAGCCTTCTGTTTGATAGAGATGAAGCGCTGCTTGATTTTCTGTTTCAACTTCTAAAAAAATAGTCGCTGAAGCTGAATTTTCTAAAATCATTCGGAGCGCAGACTGTAACACTTGACGGCCAAGACCGCGACCTCGTTGCGTTTTTGTCACAACAAAGCCATAAATCCCCCATTCGTTTTCAAAATGATCCAAACGTAGCGTGGCTAAAAGTTGATTGTTTTCTTTATAAATAAGTGTTCGTTGAAGGTCCTCCGGCAAAGGCGTACCTTCTAGTAACCTAGCCAAGGAATGCAAATCAGCCACTTGTGGTCGGAGAAGTGTCAGCTTCGCCAATTCCTGTGAGTAAGTTTCTCTTTGAAAAACCAGATACTGTTCTGAAAAAGCTGGCACAATTCCTTGTCTATTAAAATAATTCAGGCCAACAGATTGCTTGTCGTCCATCACGAGAAAGACTTCTTTCATTCCCCACAAAGCTGCTTGCTTTTCGAGTTCTTGAACAAGTTCTTCAAAAAATGGCCCTACATTTGGCGCAACAATCGTCGCTTCCAAGGTTTCCCCATCAAAACAATACCCTACGATATACGCTTGTATGGTTTGTTCCTTCCTGTATAAACCATAATAAGTATAAGCTGATTCCTCAGGAAATGTTTGTTCCAATTTATAAAAAGTTCCTTGTTTAATCATTTCCTTGTTTTTTAATTCAGTCAATGTTTGTTTCTCCAACTGTGTTAACTGTCGGCGCCAATTTATTTTTTTATTCAAGCAGTTGCTCCTTTACTCATCCTTTTACTAGCTATTATACGTGAAGTTACGAAGTTCAACAATGTACAAGGATAAAACGTTTGCGCTTTTTTTGAAAAAGTACTATCATAAAGTAAGTAAAAGAAAAATGGAGGGATTTACATGACAAAAAAAATTGGTATTTTTGTAGGGAGTTTAAGAAAAGATTCATTTAACAAATTGGTAGCAAAAACAATGGCGGACTTATTTCCAGCTGATTTCGAACCTGTTTTTATTAACATTGGTGATTTAGAATTATACAATCAAGATTTGGATGATGAAGGAACCCCCACCGAAGCTTGGACAACATTCCGTGAAGAAGTCAAACAAGTAGATGGTGTGATGTTTGTAACACCAGAATATAACCGTTCAGTACCAGCTGTTTTAAAAAATGCATTGGATGTCGGTTCACGTCCGTATGGCGAAAGCGTTTGGGATAAAAAACCAGGACTTGTGGTGAGTGTTTCACCAGGTGCAATTAGCGGATTTGGTGCGAACCATCATTTAAGACAATCATTAGTCTTCTTAAATGTTCCAACTTTACAACAACCTGAAGCCTATATTGGCGGTATTACGAACTTAATTGGTGAAGATGGTAAAATTATTGATGGCACTGTTGGCTTCTTACAATCAATTGTAGATGCTTACGTGGATTTCTTTAATCGCTTAACTGCCTAATTGAATCAATCGAGAAAAAGTGAGGCAACTTTTTAAAGGTTGTCTCACTTTTTTTATTTTTTTGCTTGACCCTCTCGTTACGTAAAGGTTTATGATAGATTTTGTCAGGAGGAATGAATGATGGAATATACAATTAAAAAAATGGCTTCACTATCTGGCGTCAGTGCACGGACGTTACGATATTATGATGAAATTGGTCTTCTTCAACCAGCCAGAATTAATTCTTCTGGTTATCGAATTTACGGGCAAGCCGAGGTGAATCGTTTGCAACAAATTCTTTTTTACCGTGAATTGGATCTGAAACTAGATGAAATTAAAGAAATTTTGGAGCAACCTGACTTTAATGTTGAACAGGCTTTATACGAGCATCAACAAAAACTATTGGAAAAGCGCAATGAAATTGATCGTCTTTTAGCCTCTGTTCAACAAACCTTACACCATTACAAAGGAGAGATAAACATGTCAGATCAGCAAAAATTCGAAGCATTCAAACAACAAAAAGTTCAAGAAAACGAAGAAAAATATGGTAAAGAGATTCGGGAAAAATATGGCAACGAAACGATTGAACAAGCCAACAAAAAATATTTAAACTTGACGGAAAAAGACATGCAAGCAATGCAAAACGTGGAAAAAGATTTATTTTCTAAGTTAGCCATGTATCAAAAATCACCCAAGTTGACTAGCCAACTTGCGCAAGAAATTTTCCAATTACACAAAGATTGGTTAATGTACTCTTGGTCAAGCTATTCGCCAGAAGCACATAAAGGGTTAGGGCTTATGTATGTTGGTGATGAACGATTTACGTCATATTATGAACAACACGGCGCTGGTTTTGCCGAATCGTTAAACGCAATTATCCAAAACTACGCTTAAACAGAAAGTGCGCCATCAGTCGAAGAGACTGATGGCGCACTTTCTGTTTCTTACGATAATTAACTAAAGCCTGTTTATCTTTTTTTCTTTTTCTTCTTTTTGTTTTTCTTCATCATACGATTCATAGCCATTTTACCTAGCTTGCCTTTAACGCCGCCACCTAACATTTGATCCATACCAGGAATGTTCATATCCCCTTTGGACATTTGTTGCATCATTTTTTTGGATTCTTTAAATTGTTTAATCATACGATTGACTTCAACCACACTATTTCCTGAACCAGCTGCAATTCTGCGGCGGCGACTAGGATTTAATAGATCAGGATTTTCACGTTCTGCAGGGGTCATTGATAAGACCATCGCCCGTTTCCGTGCCACATCTTTTGGATCGACTTTGACATTTTCAATACCAGGCATGTTACTCATTCCAGGGATCATTTTTAATAAGTCCTCAATCGGTCCCATGCCCATAACTTGATCCAATTGCTCAATAAAATCGTTAAAGTCAAAACTGTTTTCTTTCATTTTTTGAGCAAGTTCTTCTGCTTTTTTCTCATCGTAATCTTGTTGCGCTTTTTCAATTAGCGTCAACATGTCCCCCATACCTAGGATACGACTCGACATACGATCGGGATGGAAAATTTCTAAATCGGTTAATTTTTCACCAGAACCGACAAATTTAATCGGAGCGCCCGTTACTGCCCGAATTGACAGCGCAGCCCCCCCACGAGTATCGCCGTCCATTTTGGTAATAACAACCCCAGTAATTCCAAGCTGTTCATTAAAACTATCTGCAACGTTGACAGCATCTTGCCCCGTCATCGCATCAACAACTAACAGAATTTCATTGGGATTAGCCAACTCTTTAATTTGTTTCAATTCGTCCATTAAAGCTTCGTCAATGTGTAAACGGCCGGCCGTATCAATTAAGACATAATCATTTTTCTTTTCTTTTGCTAATGCTAACCCTTGACGAACAATTTCCACTGGATTAGCATCTGTTCCCATATCAAAAACGGGAACTTCTAATTGTTGACCTAAAACCTTCAACTGATCAATCGCTGCTGGACGATAAACGTCACCAGCGATTAAAAGCGGACGAGCGTTTTCAGTTTTCATTAAGTGTTTTGCTAATTTACCAGTAAAAGTTGTTTTACCAGCCCCTTGTAACCCTGTCATCATAATCACTGTCGGGATTTTTGGAGATTTATTCAGTTCAACCGTTTCTGAACCTAACGTTTTCGTTAATTCTTCATCAACAATTTTTACAATTTGTTGGGCTGGTGATAAGCTTTCTAATACTTCGACTCCTACTGCCCGTTCTCTGACGCGTTTTGTGAAATCTTTGACCACTTGTAAATTAACGTCGGCTTCTAATAAAGCCAAACGGATTTCTCGCATCATTTCTTTTACGTCGGCTTCGGAAACTTTTCCCTTACGACGGATTTTACTCATTGCCTGTTGTAGGCGGTTTGTTAAACTCTCAAAAGCCATAGTTTCATTCCTCTATTTCTTGAATTTGTTCAATATATTTTTTGATTTCACTATCTTTGGGATAAGTTTCTTGAACATACTGCTGTAGTTGTTCAAGATATTCTTTCCGTACAACATAGTTTGAATAAAGATGTAACTTTTTTTCGTATTCTTCTAAAATTTTTTCGGTTCGTTTAATGTTATCATAAACCGCTTGGCGACTAACCTCATATTCTTCCGCAATTTCTCCTAAAGAAAAGTCATCAGCATAGTAAAGCTCCATATAATTCATCTGCTTTTCCGTTAATAATGTCGAATAAAATTCAAATAACGCATTCATGCGGTTTGTTTTTTCCATTTCCATGAGCCGTGCTCCCATCTTCAATCCCTTATAGGTTACCGATTTCATAGGGAATAGTCAATCTTTTTTTACTAAGTTTTTACCTTTTAAAAAGAAATGTCCGCAAGTTGCCATGTTTCTTCAGAATAAACGGTCATTCCTTGTTGAATAAAATAAGCAGTTGCGACTCCAACTCCAGCTTTTTTAATGCCAGAAAATTGTCCATCATAAATCAGCTGGCTGCCACAGCTGGGACTTTTTTCTTTCAAAATCAAGGTTGTAATTTGTTGAGTTTTTAATTTTTGATACGCGCGTTGTGCCCCTGCTTTAAATGCCTCAGTCACATCTTCCCCGTTATCCGTATATACATAAGCAGTATTCGCCCAAACATCAAAGCCATCCCCGCCAATGATTTCTGCTGGCGGACGTGGAATAGGCAACTCTCCTAAAACTTCGGGACAAATCATTATTGCTTTTCCATTAGTTACAAGTTGTTTTAACGCTTCTTGTTCTTGAGATTTTCCATCGTAACGGCAACAAATCCCACCTAAGCAACTACTAATACCAATCATTCGCTTCTCCTCATTTCATTTCTCTATTATACCATGAGTTGACTTTTCTCAAAAGTAGCATTCTCGCTTACTTTAAAGTACGTTCTTCCTCTAAAAATATGTTAAACTAACAATAGTGAAATATACACTTATTTTCAGAAATTTCTTGAAGGAGTTATGTAAATGAAAAAAGTTCTTGTCGTCGATGATGAACCATCGATTTTAACTTTGTTAACCTTTAATTTGGAAAAAGAAGGCTATCAGGTGACTACTTCCGAAGATGGTAAAAACGGCTTCGAATTAGCTTTGTCTAATCAATATGATTTTATAATTTTAGATGTAATGCTTCCTGGTATGGATGGCTTAGAAATTACCAAAGCACTTCGTCGAGAAAAAATTGACACGCCTATTTTGATTTTAACTGCCAAAGATGAACAAGTAGATAAAATCATCGGCTTAGAAATTGGGGCAGATGATTATTTAACAAAACCTTTTAGTCCCAGAGAAGTCCTAGCACGCATGAAAGCTATTTTTCGTCGTTTAAAACCTACCACGACCGAACCGCTTCAAGAGGACACACCTAAAGCTCCGCTTGTGATTGGCGAGATTCGTGTGGATGAACAAAATTATGAAGTCTTTGTGCGCAATCAGCCCATTGAACTAACACCGAAAGAATTTGAATTACTCGTTTACTTTATGAAACGCAAAGATCGGGTCATTAATCGGGAAACCTTGTTGGAACGAATTTGGCAATATGACTTCGCTGGACAAAGTCGCATCGTCGATGTCCACATTAGTCATTTACGTGATAAAATCGAGCCTGATCCCAAACGGCCCGTTTACTTAGTAACTGTCCGTGGCTTTGGCTACCGTTTTCAGGAGCCAAAACGATGAAAAAGAGACTGCGGATTGAATATTTTTTAGTTGCGGCAGTCATGCTTTTATTATTTGTCGGAAGTATTGCAGCGACCAATTTTTTCTTTCAAAAAGAAATGGTTGCTCAGCAAGAAACCTATTTAAGAAGAAAAAATACCCTTTTAACAGACCAGTTGCCCCCTTCCGTTTTCGAAAAAGGGCAACTGACAAACCAACAACAACTCCTTGTCACCCATGCGTTAGATGATGCAGAAGAACGGGTAACTTTGTTGCAAAAAAATGGTACCGTCTTTTTTGACAGCAGCCAAAATGAACCGCTAGAGTCGCACAAAAAACGACCTGAAATCGCTGCGGTTCTATCAGGAGCTACCTATGGTTCAGC
+>4_1#NODE_16_length_39898_cov_63.337_ID_31
+CGCGCGCGCCGTTATTCAGTAGCTCTTCTGCCAGCGAAATCCCCATTTGTTCGGCATCTTGCGGCGCACCGCGGCGTTCACCGCGAATAATCTGCGAACCGTCCGGCGCGCCGACCAGCGCACGCAGCCAGATTTCGCCATCAATAAGCTCGGCGTAGCTACCAATTGGCACCTGACATCCGCCTTCGAGACGGGTATTCATGGCGCGTTCTGCGGTAACGCGCAGTGCAGTTTCGTGGTGATTCAGCGCGGCAAGCAGCTCGCGAGTGCGTGAATCATCAAGGCGGCATTCAATACCCACCGCACCTTGTCCTACCGCCGGAAGAGAAATCTCGGGTGGCAACGCGGCGCGAATACGTGACTCCAGACCTAAACGTTTTAGTCCGGCTACGGCAAGAATGATGGCATCGTATTCGCCGTTATCCAGTTTGCTCAGGCGAGTGCCGACGTTGCCGCGCAGGGAGCGGATAATCAGATCCGGACGGCGTTCAGCCAGTTGGCACTGGCGACGTAAACTGGACGTCCCGACGATACTGCCTGCCGGTAACGCATCCAGACTGTCATAGTTATTGGACACAAAGGCATCGCGAGGATCTTCACGCTCACAAATAGTGACCAGTCCCAGACCTTGCGGGAATTCAACCGGCACATCTTTCATTGAGTGTACGGCGATATCGGCGCGATTTTCGAGGAGCGCGACTTCCAGCTCTTTTACAAATAAGCCTTTTCCGCCTACTTTCGCCAGCGGCGTATCAAGAATCACATCGCCGCGCGTCACCATCGGTACCAGTTCAACGACCAGGCCCGGATGGCTCGCCATCAACTTGTCTTTGACATAGTGTGCCTGCCAGAGTGCAAGTGGGCTTTGGCGTGTGGCAATTCTTAAAACATTGTCTAACATGCTTGTTACCGTCATTATCATCCGTGGTCCATCCTAACATCCTTGCCAGAGTGATGTCAGTGTTGTGGTGAAACGTAGACGCCTGCGCAAACCGTAAAATGAGGTCTGGCAGTGGATCCTGACAGGCGTTTCACGCCGTTGTAATAAGGAATTTACAGAGAATAAACGGTGCTACACTTGTATGTAGCGCATCTTTCTTTACGGTCAATCAGCAAGGTGTTAAATTGATCACGTTTTAGACCATTTTTTCGTCGTGAAACTAAAAAAACCAGGCGCGAAAAGTGGTAACGGTTACCTTTGACATACGAAATATCCCGAATGCCGCGTGTTACCGTTGATGTTGGCGGAATCACAGTCATGACGGGTAGCAAATCAGGCGATACGTCTTGTACCTCTATATTGAGACTCTGAAACAGAGACTGGATGCCATAAATCAATTGCGTGTGGATCGCGCGCTTGCTGCTATGGGGCCTGCATTCCAACAGGTCTACAGTCTACTGCCGACATTGTTGCACTATCACCATCCGCTAATGCCGGGTTACCTTGATGGTAACGTTCCCAAAGGCATTTGCCTTTACACGCCTGATGAAACTCAACGCCACTACCTGAACGAGCTTGAACTGTATCGTGGAATGTCAGTACAGGATCCGCCGAAAGGTGAGCTTCCAATTACTGGTGTATACACCATGGGCAGCACCTCGTCCGTAGGGCAAAGTTGTTCCTCTGACCTGGATATCTGGGTCTGTCATCAATCCTGGCTCGATAGCGAAGAGCGCCAATTGCTACAACGTAAATGTAGCCTGCTGGAAAACTGGGCCGCCTCGCTGGGTGTGGAAGTCAGCTTCTTCCTGATTGATGAAAACCGCTTCCGTCATAATGAAAGCGGCAGCCTGGGGGGCGAAGATTGTGGCTCCACCCAGCATATACTGCTGCTTGACGAATTTTATCGTACCGCCGTGCGTCTCGCCGGTAAGCGTATTCTGTGGAATATGGTGCCGTGCGACGAAGAAGAGCATTACGACGACTATGTGATGACGCTTTACGCGCAGGGCGTGCTGACGCCAAATGAATGGCTGGATCTCGGTGGCTTAAGCTCGCTTTCTGCTGAAGAGTACTTTGGTGCCAGCCTTTGGCAGCTCTACAAGAGTATCGATTCCCCATACAAAGCGGTACTGAAAACACTGCTGCTGGAAGCCTATTCCTGGGAATACCCGAACCCACGTCTGCTGGCGAAAGATATCAAACAGCGTTTGCACGACGGCGAGATTGTATCGTTTGGTCTCGATCCATACTGCATGATGCTGGAGCGTGTTACTGAATACCTGACGGCGATTGAAGATTTTACCCGTCTGGATTTAGTACGTCGCTGCTTCTATTTAAAAGTGTGCGAAAAGCTCAGCCGTGAACGCGCCTGCGTAGGCTGGCGTCGCGCAGTGTTGAGCCAGTTAGTGAGCGAGTGGGGTTGGGACGAAGCTCGTCTGGCAATGCTCGATAACCGCGCTAACTGGAAGATTGATCAGGTGCGTGAGGCGCACAACGAGTTGCTCGACGCGATGATGCAGAGCTACCGTAATCTGATCCGCTTTGCGCGTCGCAATAACCTTAGCGTCTCCGCCAGTCCGCAGGATATCGGCGTGCTGACGCGTAAGCTGTATGCCGCGTTTGAAGCATTACCAGGTAAAGTGACGCTGGTAAACCCGCAGATTTCACCCGATCTCTCGGAACCGAATCTGACCTTTATTTATGTGCCGCCGGGCCGGGCTAACCGTTCAGGTTGGTATCTGTATAACCGCGCGCCAAATATTGAGTCGATCATCAGCCATCAGCCGCTGGAATATAACCGTTACCTGAATAAACTGGTGGCGTGGGCATGGTTTAACGGCCTGCTGACCTCGCGCACCCGTTTGTATATTAAAGGTAACGGCATTGTCGATTTGCCTAAGTTGCAGGAGATGGTCGCCGACGTGTCGCACCATTTCCCGCTGCGCTTACCTGCACCGACACCGAAGGCGCTCTACAGCCCGTGTGAGATCCGCCATCTGGCGATTATCGTTAACCTGGAATATGACCCGACAGCGGCGTTCCGCAATCAGGTGGTGCATTTCGATTTCCGTAAGCTGGATGTCTTCAGCTTTGGCGAGAATCAAAATTGCCTGGTAGGTAGCGTTGACCTGCTGTACCGCAACTCGTGGAACGAAGTGCGTACGCTGCACTTCAACGGCGAGCAATCGATGATCGAAGCCCTGAAAACTATTCTCGGCAAAATGCATCAGGACGCCGCACCGCCAGATAGCGTGGAAGTCTTCTGTTATAGCCAGCATCTGCGCGGCTTAATTCGTACTCGCGTGCAGCAACTGGTTTCTGAGTGTATTGAATTGCGTCTTTCCAGCACCCGCCAGGAAACCGGGCGTTTCAAGGCGCTGCGCGTTTCTGGTCAAACCTGGGGGTTGTTCTTCGAACGCCTGAATGTATCGGTACAGAAACTGGAAAACGCCATCGAGTTTTATGGCGCGATTTCGCATAACAAACTGCACGGCCTGTCAGTGCAGGTTGAAACCAATCACGTCAAATTACCGGCGGTGGTGGACGGCTTTGCCAGCGAAGGGATCATCCAGTTCTTTTTCGAAGAAACGCAAGACGAGAATGGCTTTAATATCTACATTCTCGACGAAAGCAACCGGGTTGAGGTATATCACCACTGCGAAGGCAGCAAAGAGGAGCTGGTACGTGACGTCAGTCGCTTCTACTCGTCATCGCATGACCGCTTTACCTACGGCTCAAGCTTCATCAACTTCAACCTGCCGCAGTTCTATCAGATTGTGAAGGTTGATGGTCGTGAACAGGTGATTCCGTTCCGCACAAAATCTATCGGTAACATGCCGCCTGCCAATCAGGATCACGATACGCCGCTATTACAGCAATATTTTTCGTGATGAACGTGCCGGAAAGCGAGGCTTATCCGGCATGCAATCTTAGCGGAAACTGACTGTTTCACCCGCCTGCTGCGTCGCCGCCTGTTCCAGCAAATCCCAGAAGGTTTCGCCGCTGCGATCACAAATCCACTCATCGCCTTTCAGGTCAAAATGGTAGCCGCCCTGTTTGGTTGCCAGCCATACCTGGTGCAGCGGCTCCTGGCGGTTGATAATGATTTTGCTGCCATTCTCAAAGGTAATGGTCAGTACGCCGCCGTTGATTTCGCAGTCGATATCGCTGTCGCCATCCCAGTCGTCCAGGCGTTCTTCAATGGTCAGCCAGAGTTGATCAGCCAGGCGATGAAATTCACTGTCGTTCATTGTTGTATCCTGTTTTTAAGTGATGGCGGCAGTATAGCGGCATGGGGTCAGGGCTTCAAAGTTTGCACCTCTGCGGCTGCGTTCCGGCACGATTCATCCGTCACCGGAATAATGATGTCTCTGTGTAGCGAAAGATTTGTCTCTTCATTAGGGCGCAGTTACACCACGTCTTTCCCTGTTTCTGGTAAACATTATGATCAGGTTTACCGAGCGAGCATCCTCACGCTGACGGAACTAAAAAAGACAACAAACAAACCACATTGCGATAGTGCATAAAGCCATCCTGGCGCGAGGTGCCGATCACGAAACTACCAGCAAAACATAAATCCCCACGAGTAAGCGTTATACTCGCAGCATTTCCTCACTTTTCAGACTTCATAAAGAGTCGCTAAACGCTTGCTTTTACGTCTTCTCCTGCGATGATAGAAAGCAGAAAGCGATGAACTTTACAGGCAATCCATAATGAAAAACGTGTTTAAGGCACTCACTGTATTACTTACTCTCTTCAGCCTGACGGGCTGCGGTCTGAAAGGTCCGCTCTATTTCCCGCCTGCAGATAAAAACGCACCGCCGCCGACCAAACCGGTAGAGACGCAAACGCAATCCACGGTGCCGGATAAAAACGATCGCGCCACTGGCGATGGTCCATCCCAGGTGAATTACTAAAAGTCAGTTTCTGTACCCGCGTGATTGGAGTAAATGATGCAGTTCTCGAAAATGCATGGCCTTGGCAACGATTTTATGGTCGTCGACGCGGTAACGCAGAATGTCTTTTTTTCACCGGAGCTGATTCGTCGCCTGGCTGATCGGCACCTGGGGGTAGGGTTTGACCAACTGCTGGTGGTTGAGCCGCCGTATGATCCTGAACTGGATTTTCACTATCGCATTTTCAATGCTGATGGCAGTGAAGTGGCGCAGTGCGGCAACGGTGCGCGCTGCTTTGCCCGTTTTGTGCGTCTGAAAGGACTGACCAATAAGCGTGATATCCGCGTCAGCACCGCCAACGGGCGGATGGTTCTGACCGTCACCGATGATGATCTGGTCCGCGTAAATATGGGCGAACCCAACTTCGAACCTTCCGCCGTGCCGTTTCGCGCTAACAAAGCGGAAAAGACCTATATTATGCGCGCCGCCGAGCAGACAATCTTATGCGGCGTGGTGTCGATGGGAAATCCGCATTGCGTGATTCAGGTCGATGATGTCGATACCGCGGCGGTAGAAACGCTTGGTCCTGTTCTGGAAAGCCACGAGCGTTTTCCGGAGCGCGCCAATATCGGTTTTATGCAAGTGGTTAAGCGCGAGCATATTCGTTTACGCGTTTATGAGCGTGGGGCAGGAGAAACCCAGGCCTGCGGCAGCGGCGCGTGTGCGGCGGTTGCAGTAGGGATTCAGCAAGGTTTGCTGGCCGAAGAAGTACGCGTGGAACTCCCCGGCGGTCGTCTTGATATCGCCTGGAAAGGTCCGGGTCACCCGTTATATATGACTGGCCCGGCGGTACATGTCTACGACGGATTTATTCATCTATGAAGCAACCAGGGGAAGAACTGCAGGAAACACTCACGGAGCTTGATGACCGGGCGGTTGTCGATTATCTGATTAAAAATCCTGAGTTTTTTATCCGTAATGCGCGCGCAGTAGAAGCGATACGTGTGCCGCATCCGGTACGCGGCACCGTTTCGTTGGTCGAGTGGCACATGGCCCGCGCACGTAATCATATTCATGTTCTGGAAGAGAACATGGCGCTGTTGATGGAACAGGCTATCGCCAACGAAGGCCTGTTTTATCGCCTACTCTACCTGCAGCGCAGTCTCACCGCCGCCAGCAGTCTCGACGATATGCTGATGCGCTTTCACCGCTGGGCGCGCGATCTCGGCCTGGCAGGTGCGAGTCTGCGCCTGTTTCCGGATCGCTGGCGCTTAGGTGCGCCGTCGAACCACACTCATCTGGCATTAAGCCGTCAGTCTTTCGAACCGCTGCGTATTCAGCGTTAGGGGCAGGAACAGCACTATCTTGGGCCGCTTAACGGACCAGAGCTGCTGGTGGTGCTACCGGAAGCGAAAGCGGTGGGATCGGTGGCGATGTCGATGCTGGGAAGCGATGCTGATTTGGGTGTCGTGCTGTTTACCAGTCGCGATGCCAGTCACTATCAACAAGGGCAAGGAACGCAGTTACTTCATGAAATTGCGCTGATGTTGCCGGAGCTTCTGGAGCGTTGGATTGAACGCGTATGACCGATTTACACACCGATGTAGAACGCTACCTACGTTATCTGAGCGTGGAGCGCCAGCTTAGCCCGATAACCCTGCTTAACTACCAGCGTCAGCTTGAGGCGATCATCAATTTTGCCAGCGAAAACGGCCTGCAAAGCTGGCAGCAATGTGATGTGACGATGGTGCGCAATTTTGCTGTACGCAGTCGCCGTAAAGGGCTGGGAGCAGCAAGTCTGGCGTTACGGCTTTCTGCGCTACGTAGCTTTTTTGACTGGCTGGTCAGCCAGAACGAACTCAAAGCTAACCCGGCGAAAGGTGTTTCGGCACCGAAAGCGCCGCGTCATCTGCCGAAAAACATCGACGTCGACGATATGAATCGGCTGCTGGATATTGATATCAATGATCCCCTCGCTGTACGCGACCGTGCAATGCTGGAAGTGATGTACGGCGCGGGTCTGCGTCTTTCTGAGCTGGTGGGGCTGGATATTAAACACCTCGACCTGGAGTCTGGTGAAGTGTGGGTTATGGGGAAAGGCAGCAAAGAGCGCCGCCTGCCGATTGGTCGCAACGCTGTGGCGTGGATTGAGCACTGGCTTGATTTGCGCGACCTGTTTGGTAGCGAAGACGACGCGCTTTTTCTGTCGAAACTGGGCAAGCGTATCTCCGCGCGTAATGTGCAGAAACGCTTTGCCGAATGGGGCATAAAACAAGGGCTGAATAATCACGTTCATCCGCATAAATTACGTCACTCGTTCGCCACGCATATGCTGGAGTCGAGCGGCGATCTTCGTGGTGTGCAGGAGCTGCTGGGTCATGCCAACCTCTCCACCACGCAAATCTATACTCATCTTGATTTTCAACACCTTGCCTCGGTGTACGATGCGGCGCATCCACGCGCCAAACGGGGGAAATAATGCGTTTTTACCGGCCTTTGGGGCGCATCTCGGCGCTCACCTTTGACCTGGATGATACCCTTTACGATAACCGTCCGGTGATTTTGCGCACCGAGCGAGAGGCGCTTACCTTTGTGCAAAATTATCATCCGGCGCTGCGCAGCTTCCAGAATGAAGATCTGCAACGCCTGCGCCAGGCGGTACGGGAAGCGGAACCCGAGATTTATCACGACGTGACGCGCTGGCGTTTTCGTTCGATTGAACAAGCGATGCTCGACGCCGGGCTGAGTGCCGAAGAAGCCAGTGCAGGCGCACACGCAGCAATGATCAACTTTGCCAAATGGCGCAGCCGAATCGACGTCCCGCAGCAAACTCACGACACCTTAAAACAGCTGGCGAAGAAATGGCCGCTGGTGGCGATCACCAACGGTAACGCCCAGCCGGAGCTGTTTGGTTTGGGGGATTATTTTGAGTTTGTGCTGCGCGCTGGCCCGCACGGGCGCTCAAAACCGTTCAGCGATATGTACTTTTTGGCTGCGGAAAAACTCAACGTGCCGATCGGCGAGATCTTACATGTTGGGGACGATCTCACCACTGACGTGGGTGGGGCAATTCGCAGCGGAATGCAGGCTTGTTGGATCAGACCGGAAAATGGCGATCTGATGCAAACCTGGGACAGCCGTTTACTGCCGCATCTGGAAATTTCCCGGTTGGCATCTCTGACCTCGCTGATATAATCAGCAAATCTGTATATATACCCAGCTTTTTGGCGGAGGGCGTTGCGCTTCTCCGCCCAACCTATTTTTACGCGGCGGTGCCAATGGACGTTTCTTACCTGCTCGACAGCCTTAATGACAAACAGCGCGAAGCGGTGGCCGCGCCACGCAGCAACCTTCTGGTGCTGGCGGGCGCGGGCAGTGGTAAGACGCGCGTACTGGTGCATCGTATCGCCTGGTTGATGAGCGTGGAAAACTGCTCGCCATACTCGATTATGGCGGTGACGTTTACCAACAAAGCGGCGGCGGAGATGCGTCATCGTATCGGGCAACTGATGGGCACGAGCCAGGGCGGTATGTGGGTCGGCACCTTCCACGGGCTGGCGCACCGTTTGCTGCGTGCGCACCATATGGACGCCAATCTGCCGCAGGATTTCCAGATCCTCGACAGTGAAGACCAGCTACGCCTGCTTAAGCGTCTGATCAAAGCCATGAACCTCGACGAGAAGCAGTGGCCGCCGCGGCAGGCAATGTGGTACATCAACAGCCAGAAAGATGAAGGCCTGCGTCCGCATCATATTCAAAGCTACGGTAATCCGGTGGAGCAGACCTGGCAGAAGGTGTATCAGGCGTATCAGGAAGCGTGTGACCGCGCGGGCCTGGTGGACTTCGCCGAGCTGCTGCTGCGCGCTCACGAGTTGTGGCTTAACAAGCCGCATATCCTGCAACACTACCGCGAACGTTTTACCAATATCCTGGTGGACGAATTCCAGGATACCAACAACATTCAGTACGCGTGGATCCGCCTGCTGGCGGGCGACACCGGCAAAGTGATGATCGTCGGTGATGACGACCAGTCAATCTACGGCTGGCGCGGGGCGCAGGTGGAGAATATTCAGCGTTTCCTTAATGATTTCCCCGGTGCCGAAACTATTCGTCTGGAGCAAAACTACCGCTCTACCAGCAATATTCTGAGCGCCGCTAACGCCCTGATTGAAAACAATAACGGGCGTCTGGGTAAAAAACTGTGGACCGATGGCGCGGACGGTGAGCCTATTTCCCTCTATTGCGCTTTTAACGAACTCGATGAAGCGCGTTTTGTGGTTAACCGCATCAAAACCTGGCAGGACAACGGCGGAGCGCTTGCCGAGTGCGCCATTCTCTACCGCAGCAACGCCCAGTCGCGGGTGCTCGAAGAGGCGTTATTGCAGGCCAGTATGCCGTACCGTATTTACGGCGGGATGCGCTTCTTCGAACGCCAGGAAATCAAAGATGCGCTCTCGTATCTGCGCCTGATTGCCAACCGCAACGACGACGCGGCCTTTGAGCGTGTGGTGAATACGCCAACGCGGGGTATTGGTGACCGGACGCTGGACGTGGTACGTCAGACATCGCGCGATCGCCAGTTAACACTCTGGCAGGCATGTCGTGAGCTGTTGCAGGAAAAAGCCCTCGCCGGGCGAGCTGCCAGCGCCTTGCAGCGATTTATGGAATTAATCGACGCCTTAGCGCAGGAAACTGCCGATATGCCGCTGCATGTACAGACTGACCGGGTAATTAAAGACTCCGGCCTGCGTACCATGTATGAGCAGGAGAAGGGCGAAAAAGGTCAGACGCGTATCGAAAACTTAGAGGAACTGGTGACGGCAACGCGCCAGTTCAGCTACAACGAAGAAGACGAAGATTTAATGCCGCTGCAGGCGTTCCTCTCCCATGCGGCACTGGAAGCAGGTGAAGGGCAGGCGGATACCTGGCAGGATGCGGTGCAGTTGATGACGCTACACTCGGCGAAAGGCCTGGAGTTCCCGCAGGTGTTTATCGTTGGTATGGAAGAGGGCATGTTCCCAAGCCAGATGTCGCTGGATGAAGGCGGGCGTCTGGAAGAAGAACGCCGTCTGGCCTACGTTGGCGTAACCCGCGCGATGCAGAAACTGACGCTGACCTACGCGGAAACCCGCCGTCTGTATGGTAAAGAGGTTTACCATCGCCCGTCGCGCTTTATCGGCGAGCTGCCGGAAGAGTGTGTGGAAGAGGTGCGCCTGCGCGCCACGGTAAGCCGCCCGGTCAGCCATCAGCGGATGGGTACGCCGATGGTCGAGAACGACAGCGGCTACAAGCTCGGCCAGCGCGTACGCCACGCTAAGTTTGGTGAAGGCACCATTGTCAATATGGAAGGCAGCGGTGAGCATAGCCGTTTGCAGGTGGCATTTCAGGGCCAGGGTATTAAATGGCTGGTGGCGGCATACGCCCGGCTGGAGTCGGTGTAACGTTGCCGGATGCGGTGCTGCGCACCTTATTTGGCCTAAAAAATCATTCAGATTCAATAAATTGCAACGTCATGTAGGCCGGATAGGGCGTTTACGCCGCATCCGGCATCTGCGCCATCTTCAGTATCTGACACAAAACTATCGTTTTAACCTTTCCGCTCGACGGAAATCATGGTGACAAAAGGATAGCGTTGCCACGGGATTGCCCCGCCTTTCATATACATATGTGAAATCGTGCCATCAAGATAAAGCAGCTGCTCAACGTTCAGTTTCGCTTTGGCATAACAGGCAAAATCATAAAAATTTGTTGCCTGCTGGCTCAACAAAAACACGGCGTTCCCATGTTTATTAATCCCAACACCGTTACGAATTTTGCTTGAGGCGACGTTGGGATGAATACGCGGATTAATTACACCGTTTTCCATCAACATTGGCCCTGACTGCACCGCAAACTGAATCTCTTTACTGGTTTTGAAGGCATCCAGACGAACGATGCCGACTTTATCTCCCGCGACATAAAACACGCCGCCAGGACGGATAAAGAAATTCCCTTCACCTGAAGCGAGATTTAACGCCACCTTCTGCTGACCGTTTTCGATGTACAAACCGAGCGGCGCATAGCTTTCATCATAGATGCCGCCGTTCATCGCCATCTGCACCTGACCCTGACTATTAATATCCGCCAGCAGAGCATGTAACGTTCCCCACGCTTCGCCATTGGCTTTTTGCCAGTACATTTTCACCCGCTCTGTTTGAGGATTAACGGTATACGCCTGTACGGTCAGCGTCGGATCTGAGAGTGCGCAATCATCAGCGGCAACAGCAAACAAGGGAAGTAAGGTGAGGGCGAGAAAAATCCGTTTGAGATTCAAGGTGATCATTCCTTTACCAATGAGTAGCTGATGCGCCATTATAGGTCCTGGATGTGGGATTTTTTTATCCTGTTAGCGACCTTGACGAGTACCAAAAAGCGCGAAGTTCAACTATTGTTCTGTGGTGTTCTGTTGCGTGTTGACGGCAAAATTTTGCTGGCGTAACATGCGCGCACGATCACTCTAAGAGGACATTCGCCTTGGACACACCCAGTAGATACTGGCTCACTATCCTGTCATCCAGGATCAACTCCTAAGGCTATCCCTTTTTGCTGATAGCCTTAGCGGTTGTCAGCGACCTCAATTTTTCCCGTCGCGCTGAGTCAGGCTGTTTAATGGTCTGAAACCCAATTTGTTTCTGTGTGCCCACCGAACTGTCCGATATTTTAAGCATTGGGAGTCCCGGTCATGCTGAGCGCATTTCAACTGGAAAATAACCGACTGACCCGGCTGGAAGTCGAAGAGTCACAACCCCTTGTAAATGCAGTATGGATTGATCTTGTCGAACCGGACGACGACGAGCGACTGCGCGTACAATCTGAACTTGGCCAGAGCCTGGCAACCCGCCCGGAACTGGAAGACATCGAAGCATCGGCACGTTTCTTTGAAGACGACGACGGCCTGCATATTCACTCCTTCTTCTTCTTTGAAGATGCGGAAGATCACGCCGGTAACTCCACTGTGGCATTTACCATCCGTGATGGTCGTCTGTTTACTCTGCGTGAGCGTGAACTGCCCGCTTTTCGTCTGTATCGTATGCGTGCCCGTAGCCAGTCGATGGTAGACGGTAACGCCTACGAGTTGCTGCTGGATCTGTTCGAAACCAAAATCGAACAGTTGGCAGATGAAATTGAAAATATCTATAGCGACCTGGAGCAGTTGAGCCGGGTGATTATGGAAGGGCATCAGGGCGATGAGTACGACGAGGCGCTCTCCACTCTGGCGGAACTGGAAGATATCGGCTGGAAAGTTCGCCTGTGTCTGATGGATACCCAGCGCGCGCTCAACTTCCTGGTGCGTAAAGCGCGTTTACCGGGTGGGCAACTGGAGCAGGCGCGTGAAATCCTGCGAGATATCGAATCCCTGCTGCCGCATAACGAATCCCTGTTCCAGAAGGTGAACTTCCTGATGCAGGCGGCAATGGGTTTTATCAACATCGAGCAGAACCGCATCATCAAAATCTTCTCGGTGGTATCCGTGGTATTCCTGCCGCCGACGCTCGTTGCTTCCAGCTATGGCATGAACTTTGAGTTTATGCCAGAACTGAAGTGGAGCTTCGGCTACCCTGGCGCGATTATCTTTATGATCCTCGCGGGCCTGGCACCGTATCTGTACTTTAAGCGGAAGAACTGGTTGTAAAAAACGAGAGCGGTGGCTTAGTCTGGCTAAGCCACCTGTTATTCAAAGGCTCCAGGTATTTAACCCTTTTACCTCTTTCTCATAGAACCATTTGTTCGTGTTAACAGCAACATAGGCTGCTACGGCAATTCCCAGAATGTTAACGCCAATTAGTGCACCAACAAATAGAGATAGAATACCAAGTAATAGAACTATAATTGCTTTTTTCCATAACCCCAGGACAAATAAATATATCCAGGAACAGAAGAAAGCAATGAAATTCATTTGAATAGTTAAGCGTTGTCTTACTTTTAATGCTTTAAATGCTGCTTTATATTCTGGTGTTGCCCCCCAGAATCCAGGAAAACCATGTTGATCATAAAAATTAAATCGGTATTTCCATTTTTCACTTAATGAACCATCGTTCATATATTCCTTACTCATAAATACTCCATAACTATTGTTTTGATGAATCAGTAGGTGCAAGCATTAGCATACTGAAAGTGGAAAAATAACAAATCAAAAAAATCATCGAACCATTGCCTGAACAGGCAAAATCTTCGGCTATCATTGTGATGATAGAGATGATATATACTGCTAATGTACCAAAAACATAAGTTTTTATATAGATGAAACCACTATCACGGAGTCGCTGGCAATTCATGTTGATGACGAGATAATGGAGTACGATGGTAGAGACTATAACAAGAAAGCCTGCTTCTCCATCGTTAAAAAAGATAATAAGAAAGGCAAAAATGAAATTTATTAAAATAAATGAAAATATATAACGACGTCTGGAAATCTTACCGTTAGATGTTGGGATAAATATACGTAACATAAATTTTACATCCTTGTATGAGTCTCCGGTCAGCATGGCAATATGCCCACTCTCATGCAAGAGTCGGCATATTTTTTCAGAATATATTTATTTTTTATTTGGACGTTCTACGCTGCGTATAAATCGCATCCATCACAAAAATTGCCAGCGCCACCCAAATAAAGGCGAAAGTCACCATCTTATCGGCACCCGGTTTTTCACCATAAAACGTCACAGCCAGCAGGAACATCAGCGTCGGGCCAATGTACTGGAAAAAGCCTAACGTTGAGAGACGCAAGCGCGTGGCAGCGGCGGTAAAACACAACAGCGGTACGGTAGTGACAATACCGGCGGCGATCAGCAGTAAATTCAGCGACATCGGGTTTTGCCCCATATGGCTGGTTGAGCTGTCGGCAATAGCAAACAGGTAAATTGCCGCCACGGGCAGCAGCCACATGGTTTCGATTAACATGCCGGTTTGCGCTTCAACGGCAATCTTCTTGCGTACCAGACCGTAGAAGGCAAAACTAAATGCCAGTCCCAGCGCGATAATAGGTAGCGAACCAAAAGTCCACAGCTGGACTAACACGCCACATATCGCCAGAATCACCGCCAGCCATTGCATCCGGCGGAATCGCTCGCCGAGGAAAATCATCCCCAGCACAATGTTCACCAGCGGGTTAATAAAGTAACCAAGGCTCGCTTCCAGCATATGGTGATTGTTCACCGCCCAGATAAACAGTAGCCAGTTGCCACCAATCAGCACGGCAGAGACTGCCAGCATAAAAATTTTCTGTGGCGTCTGAATCAGCGTTTTTAAATAGGACCACTGGCGGCAAATGCTCATCAGCACCACCATAAAGAAAAACGACCAGATCACGCGATGCGTCAGGATTTCATCGGCGGGCACGTAGTAAATCAACTTGAAGTACGCTGGCGCTATACCCCAAATAAAATAAGCGGCAAGAGCGAGTAATACGCCCTGCCGCGTTTGTTTTGCATCCATCGGGAATACTCATTTTTAATTGGTAACAGCAGTTTACCTGCTTTTATGTCTTCAACCTACCATATAGGTGGCGGTGGCACTGGCAATATAAAGCTGTTCTTCATTGTGTAATTCAACGCGGGCGACGGCGACTTTATTGCCTGCACGCAACAGGCTACTAGTAGCAGTAAAACGCTCGCCCCTGCCTGGGCGCAGATAATCAACGCGAAGATCAATGGTCCCCATCCGCGATAGCCGCTGGCGTAGTTCATCTTCACTGATGGTTTCGTGGCGGGTTAAGGTACTTCCCACGCACACCAGACCGGCGGCGACATCCAGCGCCGACGCAATGACCCCGCCGTGCAAAATGCTTTGCGCCCAGTTGCCCACCATCATTGGCTGATTTTTAAAGGCCAGCTGTGCGAACTCTTTTTCGTAACGCTCCAGTTCCATCCCCAATGCGCGGTTAAATGGCATGTGATAAACAAACATCTCACCCACTAATTTCAGGGCTTGTTCAGCGGTCAGTACGGCAGACATATCATCCTTACACTTCATTGGTTAATGAAATGTTGATTTTATGCTTCTTTGTTGTTGGTTTCTACTTTAGGAAGGGATAACTAACGGCTATGGAGTTAAGTATGTAAAATAGCCCGCAGAAAAATATTCACCTTATCAATAATTCGTTACGGAGAACACGACCGATGCGGACTCTGCAGGGCTGGTTGTTGCCGGTGTTTATGTTGCCTATGGCAGTATATGCACAAGAGGCAACGGTGAAAGAGGTGCATGACGCGCCAGCGGTGCGTGGCAGTATTATCGCCAATATGCTGCAGGAGCATGACAATCCGTTCACGCTCTATCCTTATGACACCAACTACCTCATTTACACCCAAACCAGCGATCTGAATAAAGAAGCGATTGCCAGTTACGACTGGGCGGAAAATGCGCGTAAGGATGAAGTAAAGTTTCAGTTGAGCCTGGCATTTCCGCTGTGGCGTGGGATTTTAGGCCCGAACTCGGTGTTGGGTGCGTCTTATACGCAAAAATCCTGGTGGCAACTGTCCAATAGCGAAGAGTCTTCACCGTTTCGTGAAACCAACTACGAACCGCAATTGTTCCTCGGTTTTGCCACCGATTACCGTTTTGCAGGTTGGACGCTGCGCGATGTGGAGATGGGGTATAACCACGACTCTAACGGGCGTTCCGACCCGACCTCCCGCAGCTGGAACCGCCTTTATACTCGCCTGATGGCAGAAAACGGTAACTGGCTGGTAGAAGTGAAGCCGTGGTATGTGGTGGGTAATACTGACGATAACCCGGATATCACCAAATATATGGGTTACTACCAGCTTAAAATCGGCTATCACCTCGGTGATGCGGTGCTCAGTGCGAAAGGACAGTACAACTGGAACACCGGCTACGGCGGCGCGGAGTTAGGCTTAAGTTACCCGATCACCAAACATGTGCGCCTTTATACTCAGGTTTACAGCGGCTATGGCGAATCGCTCATCGACTATAACTTCAACCAGACCCGTGTCGGTGTGGGGGTTATGCTAAACGATTTGTTTTGATGAACGGTTGAGTGGTTGGCAAATCTGGAATCCAGCATCCAGGATTACCCTCTCAGAGACTAAAAGCATTGCAGTTTCTCGCGCAGGCGCTGAAAATAGCGCCTGTTTTTATTTCAGGCAATCGGGGTGAATGTGGCGCAGGCGGAAGTGTTGAATCTGGAGTCCGGAGCTAAACAGGTTTTACAAGAAACCTTTGGCTACCAACAGTTTCGCCCCGGCCAGGAAGAAATTATCGACACTGTGCTTTCCGGCCGCGATTGCCTCGTCGTCATGCCCACTGGTGGCGGAAAATCCCTTTGCTATCAAATCCCTGCCTTATTGCTAAACGGCCTTACCGTGGTTGTTTCACCGCTGATTTCGTTGATGAAAGATCAGGTGGATCAACTGCAAGCCAACGGCGTGGCGGCGGCGTGCCTTAACTCGACGCAAACCCGCGAACAGCAACTTGAAGTGATGACAGGCTGCCGCACCGGGCAAATTCGTCTGCTTTATATCGCCCCGGAACGCCTGATGCTGGATAACTTTCTTGAGCATCTGGCGCACTGGAATCCGGTGTTATTAGCCGTTGATGAAGCGCACTGTATCTCCCAATGGGGCCACGATTTCCGCCCGGAATATGCCGCGCTCGGTCAGTTGCGCCAGCGGTTCCCGACGCTGCCGTTTATGGCGCTGACCGCCACAGCCGACGACACCACGCGCCAGGATATCGTGCGCCTGCTGGGGCTGAACGATCCGCTGATTCAAATCAGCAGTTTTGACCGTCCGAATATTCGCTACATGCTGATGGAGAAGTTCAAACCGCTCGATCAGTTGATGCGCTACGTGCAGGAACAGCGCGGTAAGTCAGGCATTATCTACTGCAACAGCCGCGCGAAAGTAGAAGACACCGCTGCGCGCCTGCAAAGCAAGGGAATTAGCGCGGCGGCCTATCATGCCGGGCTGGAAAATAATGTTCGCGCCGATGTGCAGGAAAAATTCCAGCGCGATGACCTGCAAATTGTGGTGGCGACGGTGGCGTTCGGCATGGGCATCAATAAACCAAACGTTCGCTTCGTGGTCCACTTTGATATTCCGCGCAATATCGAATCCTATTATCAGGAAACCGGACGCGCCGGGCGTGATGGCCTGCCCGCGGAAGCGATGCTGTTTTACGATCCGGCTGATATGGCGTGGCTGCGCCGTTGTCTGGAAGAGAAGCCGCAGGGGCAGTTGCAGGATATCGAGCGCCACAAACTCAATGCGATGGGCGCGTTTGCCGAAGCGCAAACTTGCCGTCGTCTGGTATTGCTGAACTATTTTGGCGAAGGGCGTCAGGAGCCGTGCGGGAACTGCGATATCTGCCTCGATCCGCCGAAACAGTACGACGGTTCAACCGATGCTCAGATTGCCCTTTCCACCATTGGTCGTGTGAATCAGCGGTTTGGGATGGGTTATGTGGTGGAAGTGATTCGTGGTGCTAATAACCAGCGTATCCGCGACTATGGTCATGACAAACTGAAAGTCTATGGCATGGGCCGTGATAAAAGCCATGAACATTGGGTGAGCGTGATCCGCCAGCTGATTCACCTCGGCCTGGTGACGCAAAATATTGCCCAGCATTCTGCCCTACAACTGACAGAGGCCGCGCGCCCGGTGCTGCGCGGCGAATCCTCTTTGCAACTTGCCGTGCCGCGTATCGTGGCGCTCAAACCGAAAGCGATGCAGAAATCGTTCGGCGGCAACTATGATCGCAAACTGTTCGCCAAATTACGCAAACTGCGTAAATCGATAGCCGATGAAAGTAATGTCCCGCCGTACGTGGTGTTTAACGACGCAACCTTGATTGAGATGGCTGAACAGATGCCGATCACCGCCAGCGAAATGCTCAGCGTTAACGGCGTTGGGATGCGCAAGCTGGAACGCTTTGGCAAACCGTTTATGGCGCTGATTCGTGCGCATGTTGATGGCGATGACGAAGAGTAGTCAGCAGCATAAAAAAGTGCCAGTATGAAGACTCCGTAAACGTTTCCCCCGCGAGTCAAATGTATGTTGATGTTATTTCTCACCGTCGCCATGGTGCACATTGTGGCGCTTATGAGCCCCGGTCCCGATTTCTTTTTTGTCTCTCAGACCGCTGTCAGTCGTTCCCGTAAAGAAGCGATGATGGGCGTGCTGGGCATTACCTGCGGCGTAATGGTTTGGGCTGGGATTGCGCTGCTTGGCCTGCATTTGATTATCGAAAAAATGGCCTGGCTGCATACGCTGATTATGGTGGGCGGTGGCCTGTATCTCTGCTGGATGGGTTACCAGATGCTACGTGGTGCACTGAAAAAAGAGGCGGTTTCTGCACCTGCGCCACAGGTCGAGCTGGCGAAAAGTGGGCGCAGTTTCCTGAAAGGTTTACTGACCAATCTCGCTAATCCGAAAGCGATTATCTACTTTGGCTCGGTGTTCTCATTGTTTGTCGGTGATAACGTTGGCACTACCGCGCGCTGGGGCATTTTTGCGCTGATCATTGTCGAAACGCTGGCGTGGTTTACCGTCGTTGCCAGCCTGTTTGCCCTGCCGCAAATGCGCCGTGGTTATCAACGTCTGGCGAAGTGGATTGATGGTTTTGCCGGGGCGTTATTTGCCGGATTTGGCATTCATTTGATTATTTCGCGGTGATGCCAGACGCGTCTTCAGAGTAAGTCGGATAAGGCGTTTACGCCGCATCCGACATTATTTTTCACGCATGCCTCGCCGATGCTAACAGCGCTCCCACCAGCATAAACAACGAGCCGAAAATCTTATTCAGCGCCTTCATCTGCTTTGGTCCTTTAATCCATAGAGCAATCCGTTGAGCAAGGGTGGCGTAACCGATCATCACAATAATATCGACCACAATAGTGGTGACGCCGAGCACGATATACTGCATCAGTTGCGGCTGTTGCGGCATGATGAATTGCGGAAATAGCGCCGCCAGAAACACAATACTTTTGGGATTGGTGAGATTCACAAAAACTGCGCGCTGGAACAAATGTCGACGCGATTGAGTAGAGGCCAGCGATTTAAGGTCAATTGCACCAGCGGCGCGCCACTGCTGGATTCCCAGCCAAATCAAGTAAGCCGCGCCTGCCCACTTCAACACTTCAAACGCAATCACTGAGCGGGAAAATAGCGTCCCCAACCCCACGCCAACCAGCACAATATGAATCGCCAGTCCGGTCTGAAGCCCAGCAATAGACGCCACCGCGCCGCGATAACCGTGGTTGAGCGAGGTGGTCATAGTGTTGATTGCACCAGAGCCTGGCGACAGGCTTAAAATGATCGATGTCAGCAGGTAGGCAAACCACCATTCTAAGGTCATGATGAACTCCCGGTGTGTCTATTTTTGTGCCACAATACGCTACTGTCGCAGCGTTGTGTCAGGCACGCTAAAAAAAACGATTTTACGTGGTTTAAGAGGCAGATTACCCGATGTTTCAGCAGCAAAAAGACTGGGAAACAAGAGAAAACGCGTTTGCTGCTTTTACCATGGGACCGCTGACTGATTTCTGGCGTCAGCGTGATGAAGCAGAGTTTACTGGTGTGGATGACATTCCGGTGCGCTTTGTCCGTTTTCGCGCACAGCACCATGACCGGGTGGTAGTCATCTGCCCGGGGCGTATTGAGAGCTACGTAAAATATGCGGAACTGGCCTATGACCTGTTCCATTTGGGGTTTGATGTCTTAATCATCGACCATCGCGGGCAGGGACGTTCCGGTCGCCTGTTAGCCGATCCGCATCTCGGGCATGTTAATCGCTTTAATGATTATGTTGATGATCTGGCGGCATTCTGGCAGCAGGAGGTTCAGCCCGGTCCGTGGCGTAAACGCTATATACTGGCACATTCGATGGGCGGTGCGATCTCCACATTATTTCTGCAACGCCATCCAGGTGTATGTGACGCCATTGCGCTAACTGCGCCAATGTTTGGGATCGTGATTCGTATGCCGTCATTTATGGCACGGCAGATCCTCAACTGGGCCGAAGCGCATCCACGTTTCCGTGATGGCTATGCAATAGGCACCGGGCGCTGGCGCGCGTTGCCGTTTGCTATCAACGTACTGACCCACAGCAGACAGCGATATCGACGTAACTTACGCTTCTATGCTGATGACCCAACGATTCGCGTCGGTGGGCCGACCTACCATTGGGTACGCGAAAGTATTCTGGCTGGCGAACAGGTGTTAGCCGGTGCGGGTGATGACGCCACGCCAACGCTTCTCTTGCAGGCTGAAGAGGAACGCGTGGTGGATAACCGCATGCATGACCGTTTTTGTGAACTCCGCACCGCCGCGGGCCATCCTGTCGAAGGAGGACGGCCGTTGGTAATTAAAGGTGCTTACCATGAGATCCTTTTTGAAAAGGACGCAATGCGCTCAGTCGCGCTCCACGCCATCGTTGATTTTTTCAACAGGCATAACTCACCCAGCGGAAACCGCTCTACAGAGGTTTAAATTTCTTATGTACCAGGTTGTTGCGTCTGATTTAGATGGCACGTTACTTTCTCCCGACCATACGTTATCCCCTTACGCCAAAGAAACTCTGAAGCTGCTCACCGCGCGCGGCATCAACTTTGTGTTTGCGACCGGTCGTCACCACGTTGATGTGGGGCAAATTCGCGATAATCTGGAGATTAAGTCTTACATGATTACCTCCAATGGTGCGCGCGTTCACGATCTGGATGGTAATCTGATTTTTGCTCATAACCTGGATCGCGACATTGCCAGCGATCTGTTTGGCGTAGTCAACGACAATCCGGACATCATTACTAACGTTTATCGCGACGACGAATGGTTTATGAATCGCCATCGCCCGGAAGAGATGCGCTTTTTTAAAGAAGCGGTGTTCCAATATGCGCTGTATGAGCCTGGATTACTGGAGCCGGAAGGCGTCAGCAAAGTGTTCTTCACCTGCGATTCCCATGAACAACTGCTGCCGCTGGAGCAGGCGATTAACGCTCGTTGGGGCGATCGCGTCAACGTCAGTTTCTCTACCTTAACCTGTCTGGAAGTGATGGCGGGCGGCGTTTCAAAAGGCCATGCGCTGGAAGCGGTGGCGAAGAAACTGGGCTACAGCCTGAAGGATTGTATTGCGTTTGGTGACGGGATGAACGACGCCGAAATGCTGTCGATGGCGGGGAAAGGCTGCATTATGGGCAGTGCGCACCAGCGTCTGAAAGACCTTCATCCCGAGCTGGAAGTGATTGGTACTAATGCCGACGACGCGGTGCCGCATTATCTGCGTAAACTCTATTTATCGTAATCGTTCTTTATTTGGTCAGTTGTCAACCTGATACTTCGCTACAATGGATACCCGTTAATCAAAGAGTTTTCCATTGTGGCGCTACTTATCATCACCACGATTCTGTGGGCCTTCTCCTTTAGCTTTTATGGCGAGTACCTTGCGGGGCACGTCGATAGCTATTTTGCGGTGCTGGTGCGCGTTGGCCTGGCGGCACTCGTTTTTCTGCCGTTTCTGCGTACCCGTGGCAATAGCCTGAAAACGGTCGGCCTGTATATGCTGGTGGGCGCGATGCAGCTTGGCGTGATGTATATGCTGAGTTTCCGCGCTTATCTCTACCTGACGGTTTCCGAGCTGCTGCTGTTCACCGTGCTGACGCCGCTCTACATCACGCTGATTTATGACATCATGAGTAAGCGCCGTCTGCGCTGGGGCTATGCCTTTAGCGCCTTGCTGGCGGTGATTGGTGCCGGGATTATTCGCTATGATCAGGTCACCGACCATTTCTGGACTGGCTTGCTGCTGGTGCAACTCTCCAATATCACTTTTGCCATTGGCATGGTGGGTTACAAACGCCTGATGGAAACTCGCCCGATGCCACAGCATAACGCCTTTGCGTGGTTCTATCTTGGCGCGTTTCTGGTGGCAGTGATTGCATGGTTCTTGCTGGGAAATGCGCAGAAAATGCCGCAAACCACGCTGCAATGGGGCATTCTGGTGTTTCTTGGCGTGGTGGCTTCCGGGATTGGCTACTTTATGTGGAACTACGGCGCGACGCAGGTGGACGCCGGAACGCTGGGCATTATGAATAATATGCACGTTTCGGCAGGGCTGCTGGTAAACCTGGCTATCTGGCACCAACAGCCGCACTGGCCAACGTTTATTACAGGCGCGCTGGTGATCCTGGCCTCACTGTGGGTGCATCGTAAGTGGGTCGCTCCGCGCTCTTCACAAACGGCAGATGATCGCAGGCGTGATTGCGCGCTGAGCGAATAAACGCTTCCGTAACTGGCTGACGCTGCTCGCCATCGCGCACGGCGGCGTACAGTCGGCTCCACAAGCCTTCGCCCAGGGTTTTGGTCACCACCAGACCCTGGCGCTCAAAACTCTCTACTACCCAATGCGGTAGCGCGGCAATACCCATCCGCGCGGCAACCATCTGAATCAACAATAAGGTGTTATCGACGCTTTTCAGTGACGGGCTGACGCCTGCCGGCTGAAGAAAATGCCGCCAGACATCCAGTCGACTACGCTGCACCGGATAAATTAATAGCGTCTCGCTGGCGAGATCTTCCGGTGTAATTCGCGTTTTCGCCGCCAGTGGATGGTCAGGTGCTAACACCAGACGCACTTCATAGTCGAACATCGGCGAATAATGCAGGCCACTGCGCGGCAGAATATCGGACGTCATTACCAGATCCAGCTCTCCCTGTTGCAAGGCGGGCTGCGGGTCAAATGTCACGCCCGATTTAAAATCCATCTCTACCTGCGGCCAGTTCTTATGGAAATTTTCTAACGCGGGTGTCAGCCACTGAATACAGCTATGGCACTCAATGGCAATGCGCAGACGCGTCTGCTGCGGTTCATTGCAGGCTTGCAGGGCCTGGCTAATTTGCGGCAGTACCTGGTTTGCCAGTTGCAACAGGATTTCTCCCTGCGGTGTAAAGCGTAGCGGCTGGCTCTTACGCACAAATAGCCGGAAGCCAAGGCGTTGTTCCAGATCGCTAAACTGGTGAGACAGGGCGGATTGCGTCTGATGCAACGTCGCCGCAGCGGCTGCGAGCGAGCCGCAGTTCCGCAACGCTTGTAGCGTTTTCAGGTGTTTTACTTCGATCATGAAAGTCCTTCACTTCGGCATGAATAATTTGCGCTTGAGGAATATACAGTAACCGCCAATTATGGATGTGTAAACATCTGGACGGCTAAAATCCTTCGTCTTTTAAATTTATGGTGCGTTGGCTGCGTTTCTCCACCCCGGTCACTTACTTCAGTAAGCTCCCGGGGATGAATAAACTTGCCGCCTTCCCTAAATTCAAAATCCATAGGATTTACATATAATTAGAGGAAGAAAAAATGACAATATTGAATCACACCCTCGGTTTCCCTCGCGTTGGCCTGCGTCGCGAGCTGAAAAAAGCGCAAGAAAGTTATTGGGCGGGGAACTCCACGCGTGAAGAACTGCTGGCGGTAGGGCGTGAATTGCGTGCTCGTCACTGGGATCAACAAAAGCAAGCGGGTATCGACCTGCTGCCGGTGGGCGATTTTGCCTGGTACGATCATGTACTGACCACCAGTCTGCTGCTGGGTAACGTTCCGGCGCGTCATCAGAACAAAGATGGTTCGGTAGATATCGACACCCTGTTCCGTATTGGTCGTGGACGTGCGCCGACTGGCGAACCTGCGGCGGCAGCGGAAATGACCAAATGGTTTAACACCAACTATCACTACATGGTGCCGGAGTTCGTTAAAGGCCAACAGTTCAAACTGACCTGGACGCAGCTGCTGGACGAAGTGGACGAGGCGCTGGCGCTGGGCCACAAGGTGAAACCTGTGCTGCTGGGGCCGGTTACCTGGCTGTGGCTGGGGAAAGTGAAAGGTGAACAATTTGACCGCCTGAGCCTGCTGAACGACATTCTGCCGGTTTATCAGCAAGTGCTGGCAGAACTGGCGAAACGCGGCATCGAGTGGGTACAGATTGATGAACCCGCGCTGGTACTGGAACTACCACAGGCGTGGCTGGACGCATACAAACCCGCTTACGACGCGCTCCAGGGACAGGTGAAACTGCTGCTGACCACCTATTTTGAAGGCGTAACGCCAAATCTCGACACGATTACTGCGCTGCCTGTTCAGGGTCTGCATGTTGACCTCGTACATGGTAAAGATGACGTTGCTGAACTGCACAAGCGCCTGCCTTCTGACTGGTTGCTGTCTGCGGGTCTGATCAATGGTCGTAACGTCTGGCGCGCCGATCTTACCGAGAAATATGCGCAAATTAAGGACATTGTCGGCAAACGTGATTTGTGGGTGGCATCTTCCTGCTCGTTGCTGCACAGCCCCATCGACCTGAGCGTGGAAACGCGTCTTGATGCAGAAGTGAAAAGCTGGTTTGCCTTCGCCCTACAAAAATGCCATGAACTGGCACTGCTGCGCGATGCGCTGAACAGTGGTGACACGGCAGCTCTGGCAGAGTGGAGCGCCCCGATTCAGGCACGTCGTCACTCTACCCGCGTACATAATCCGGCGGTAGAAAAGCGTCTGGCGGCGATCACCGCCCAGGACAGCCAGCGTGCGAATGTCTATGAAGTGCGTGCTGAAGCCCAGCGTGCGCGTTTTAAACTGCCAGCGTGGCCGACCACCACGATTGGTTCCTTCCCGCAAACCACGGAAATTCGTACCCTGCGTCTGGATTTCAAAAAGGGCAATCTCGACGCCAACAACTACCGCACGGGCATTGCGGAACATATCAAGCAGGCCATTGTTGAGCAGGAACGTTTGGGACTGGATGTGCTGGTACATGGCGAGGCCGAGCGTAATGACATGGTGGAATACTTTGGCGAGCACCTCGACGGATTTGTCTTTACGCAAAACGGTTGGGTACAGAGCTACGGTTCCCGCTGCGTGAAGCCACCGATTGTCATTGGTGACATTAGCCGCCCGGCACCGATTACCGTGGAGTGGGCGAAGTATGCGCAATCGCTGACCGACAAACCGGTGAAAGGGATGCTGACGGGGCCGGTGACCATACTCTGCTGGTCGTTCCCGCGTGAAGATGTCAGCCGTGAAACCATCGCCAAACAGATTGCGCTGGCGCTGCGTGATGAAGTGGCCGATCTGGAAGCCGCTGGAATTGGCATCATCCAGATTGACGAACCGGCGCTGCGCGAAGGTTTACCGCTGCGTCGTAGCGACTGGGATGCGTATCTCCAGTGGGGCGTAGAGGCCTTCCGTATCAACGCCGCCGTGGCGAAAGATGACACACAAATCCACACTCACATGTGTTATTGCGAGTTCAACGACATCATGGATTCGATTGCGGCGCTGGACGCAGACGTCATCACCATCGAAACCTCGCGTTCCGACATGGAGTTGCTGGAGTCGTTTGAAGAGTTTGATTATCCAAATGAAATCGGTCCTGGCGTCTATGACATTCACTCGCCAAACGTACCGAGCGTGGAATGGATTGAAGCCTTGCTGAAGAAAGCGGCAAAACGCATTCCGGCAGAGCGCCTGTGGGTCAACCCGGACTGTGGCCTGAAAACGCGCGGCTGGCCAGAAACCCGCGCGGCACTGGCGAACATGGTGCAGGCGGCGCAGAACTTGCGTCGGGGGTAAAATCCAAACCGGGTGGTAATACCACCCGGTCTTTTCTCATTACAGCGACTTCTTCCCACCATACTGCTTAAACCATTCCAGCATACGCTGCCAGCCATCTTCTGCAGATGCGGCATGATAGCTCGGGCGATAATCAGCGTTGAATGCATGCCCGGCGTCCGGGTACACGATAATCTCTGCTTTCGCATTAGCAGCCCGCAGCGCCTGGCGCATGGTTTCAACGCTCTCCTGCGGAATGCTGTTATCCTGACCACCATATAAGCCGAGAATCGGCGCGTTAAGATCGGTTGCGATATCAACAGGTTGTTTCGGTGAATTCAGCGACTTGTCGCCCGTCAGTTTGCCGTACCACGCCACTGCGGCTTTTAGCTGTGGATTATGCGCGGCATACAGCCAGGTGATACGTCCACCCCAGCAGAATCCGGTGATCATTAAACGATGAACATCGCCGCCGTTGCGGGAAGCCCAACTGGCGACATGATCGAGATCGGCCAGCACCTGCGAGTCAGGCACTTTTGCTACCAGACCGCTAAGCAACGTGGGGATATCGGCAAAATCATTCGGATCGCCTTCGCGGAAGTAAAGTTCAGGTGCGATAGCCAGATACCCCTCCAGCGCCAGACGGCGACAAATGTCGCGGATATGTTCATGCACGCCAAAAATTTCCTGCACTACAATGACCACTGGCAGTGGGCCATCGCTTTGCTTTGGTCTGGCATGGTAAGCAGGCATGTTATCCCCTTGTGAAGGGATAGAGGTGAAGCCCGCCACAATCGCGTCGTCCGGGGTCTGAACGATGGTCGAAGCGAGAGGCGATGCAGCAGGTGCAAATCCAGATTGTTGTGTTGTTGCCATGGTATTCTCCGTACCCTTATAAAAATGTTGCGCAATGTTAACTATAGTCAGCATGCAACAAATCACATTGCCTGAATCGGCTCATCTTTTATGCAGTCCTGCAGAATGAAGGGTGATTTATGTGATTTGCATCACTTTTGGTGGGTAAATTTATGCAACGCATTTGCGTCATGGTGATGAGTATCACGAAAAAATGTTAAACCCTTCGGTAAAGTGTCTTTTTGCTTCTTCTGACTAAACCGATTCACAGAGGAGTTGTATATGTCCAAGTCTGATGTTTTTCATCTCGGCCTCACTAAAAACGATTTACAAGGGGCTACGCTTGCCATCGTCCCTGGCGACCCGGATCGTGTGGAAAAGATCGCCGCGCTGATGGATAAGCCGGTTAAGCTGGCATCTCACCGCGAATTCACTACCTGGCGTGCAGAGCTGGATGGTAAACCTGTTATCGTCTGCTCTACCGGTATCGGCGGCCCGTCTACCTCTATTGCTGTTGAAGAGCTGGCACAGCTGGGCATTCGCACCTTCCTGCGTATCGGTACAACGGGCGCTATTCAGCCGCATATTAATGTGGGTGATGTCCTGGTTACCACGGCGTCTGTCCGTCTGGATGGCGCGAGCCTGCACTTCGCACCGCTGGAATTCCCGGCTGTCGCTGATTTCGAATGTACGACTGCGCTGGTTGAAGCTGCGAAATCCATTGGCGCGACAACTCACGTTGGCGTGACAGCTTCTTCTGATACCTTCTACCCAGGTCAGGAACGTTACGATACTTACTCTGGTCGCGTAGTTCGTCACTTTAAAGGTTCTATGGAAGAGTGGCAGGCGATGGGCGTAATGAACTATGAAATGGAATCTGCAACCCTGCTGACCATGTGTGCAAGTCAGGGCCTGCGTGCCGGTATGGTAGCGGGTGTTATCGTTAACCGCACCCAGCAAGAGATCCCGAATGCTGAGACGATGAAACAAACCGAAAGCCATGCGGTGAAAATCGTGGTGGAAGCGGCGCGTCGTCTGCTGTAATTCTCTTCTCCTGTCTGAAGGCCGACGCGTTCGGCCTTTTGTATTTTTGCGTAGCGCCTCGCAGGAAATGCCTTTCCAACTGGACGTTTGTACAGCACAATTCTATTTTGTGCGGGTAAGTTGTTGCGTCAGGAGGCGTTGTGGATTTCTCAATCATGGTTTACGCAGTTATTGCGTTGGTGGGTGTGGCAATTGGCTGGCTGTTTGCCAGTTATCAACATGCGCAGCAAAAAGCCGAGCAATTAGCTGAACGTGAAGAGATGGTCGCGGAGTTAAGCGCGGCAAAACAACAAATTACCCAAAGCGAGCACTGGCGTGCAGAGTGCGAGTTACTCAATAACGAAGTGCGCAGCCTGCAAAGTATTAACACCTCTCTGGAGGCCGATCTGCGTGAAGTAACCACGCGGATGGAAGCCGCACAGCAACATGCTGACGATAAAATTCGCCAGATGATTAACAGCGAGCAGCGCCTCAGTGAGCAGTTTGAAAACCTCGCCAACCGTATTTTTGAGCACAGCAATCGCCGGGTTGATGAGCAAAACCGTCAGAGTCTGAACAGCCTGTTGTCGCCGCTACGTGAACAACTGGACGGTTTCCGCCGTCAGGTTCAGGACAGCTTCGGTAAAGAAGCACAAGAACGCCATACCCTGACCCACGAAATTCGCAATCTCCAGCAACTCAACGCGCAAATGGCCCAGGAAGCGATCAACCTGACGCGCGCGCTGAAAGGCGACAATAAAACCCAGGGCAACTGGGGCGAGGTAGTATTGACGCGGGTGCTGGAGGCTTCCGGTCTGCGTGAAGGGTATGAATATGAAACCCAGGTCAGCATCGAAAATGACGCCCGCTCGCGGATGCAGCCGGATGTCATCGTGCGCCTGCCGCAGGGAAAAGATGTGGTGATCGACGCCAAAATGACGCTGGTCGCCTATGAACGCTATTTTAACGCCGAAGACGACTACACCCGCGAAAGCGCGCTACAGGAACATATCGCGTCGGTGCGTAACCATATCCGTTTGCTGGGACGCAAAGATTATCAACAGCTGCCGGGGCTGCGAACTCTGGATTACGTGCTGATGTTTATTCCCGTTGAACCCGCTTTTTTACTGGCGCTTGACCGCCAGCCGGAGCTGATCACCGAAGCGTTGAAAAACAACATCATGCTGGTTAGCCCGACTACGCTGCTGGTGGCGCTGCGCACTATCGCCAACCTGTGGCGTTATGAGCATCAAAGCCGCAACGCCCAGCAAATCGCCGATCGTGCCAGCAAGCTGTACGACAAGATGCGTTTGTTCATCGATGACATGTCCGCGATTGGTCAAAGTCTCGACAAAGCGCAGGATAATTATCGGCAGGCAATGAAAAAACTCTCTTCAGGGCGCGGAAATGTGCTGGCGCAGGCAGAAGCGTTTCGCGGTTTAGGAGTAGAAATTAAACGCGAGATTAATCCGGATTTGGCTGAACAGGCGGTGAGCCAGGATGAAGAGTATCGACTTCGGTCGGTTCCGGAGCAGCCGAATGATGAAGCTTATCAACGCGATGATGAATATAATCAGCAGTCGCGCTAGCCCATTGGGAGTAGTTAAGCCGGGTAGAAATCTAGGGCATCGACGCCCAATCTGTTACACTTCTGGAACAATTTTTTGATGAGCAGGCATTGAGATGGTGGATAAGTCACAAGAAACGACGCACTTTGGTTTTCAGACCGTCGCGAAGGAACAAAAAGCGGATATGGTCGCCCACGTTTTCCATTCCGTGGCATCAAAATACGATGTCATGAATGATTTGATGTCATTTGGTATTCATCGTTTGTGGAAGCGATTCACGATTGATTGCAGCGGCGTACGCCGTGGGCAGACCGTGCTGGATCTGGCTGGTGGCACCGGCGACCTGACAGCGAAATTCTCCCGCCTGGTCGGAGAAACTGGCAAAGTGGTCCTTGCTGATATCAATGAATCCATGCTCAAAATGGGCCGCGAGAAGCTGCGTAATATCGGTGTGATTGGCAACGTTGAGTATGTTCAGGCGAACGCTGAGGCGCTGCCGTTCCCGGATAACACCTTTGATTGCATCACCATTTCGTTTGGTCTGCGTAACGTCACCGACAAAGATAAAGCACTGCGTTCAATGTATCGCGTGCTGAAACCCGGCGGCCGCCTGCTGGTGCTTGAGTTCTCGAAGCCAATTATCGAGCCGCTGAGCAAAGCCTATGATGCATACTCCTTCCATGTGCTGCCGCGTATTGGCTCACTGGTCGCGAACGACGCCGACAGCTACCGTTATCTGGCAGAATCCATCCGTATGCATCCCGATCAGGATACCCTGAAAGCCATGATGCAGGATGCCGGATTCGAAAGTGTCGACTACTACAATCTGACGGCAGGGGTTGTGGCGCTGCATCGTGGTTATAAGTTCTGACAGGAGACCGGAAATGCCTTTTAAACCTTTAGTGACGGCAGGAATTGAAAGTCTGCTCAACACCTTCCTGTATCGCTCACCCGCGCTGAAAACGGCCCGCTCGCGTCTGCTGGGTAAAGTATTGCGCGTGGAGGTAAAAGGCTTTTCGACGTCATTGATTCTGGTGTTCAGCGAACGCCAGGTTGATGTACTGGGCGAATGGGCAGGCGATGCTGACTGCACCGTTATCGCCTACGCCAGTGTGTTGCCGAAACTTCGCGATCGCCAGCAGCTTACCGCACTGATTCGCAGTGGTGAGCTGGAAGTGCAGGGCGATATTCAGGTGGTGCAAAACTTCGTTGCGCTGGCAGATCTGGCAGAGTTCGACCCTGCGGAACTGCTGGCCCCTTATACCGGTGATATCGCCGCTGAAGGAATCAGCAAAGCCATGCGCGGAGGCGCAAAGTTCCTGCATCACGGCATTAAGCGCCAGCAACGTTATGTGGCGGAAGCCATTACTGAAGAGTGGCGTATGGCACCCGGTCCGCTTGAAGTGGCCTGGTTTGCGGAAGAGACGGCTGCCGTCGAGCGTGCTGTTGATGCCCTGACCAAACGGCTGGAAAAACTGGAGGCTAAATGACGCCAGGTGAAGTACGGCGCCTATATTTCATCATTCGCACTTTTTTAAGCTACGGACTTGATGAACTGATCCCCAAAATGCGTATCACCCTGCCGCTACGGCTATGGCGATACTCATTATTCTGGATGCCAAATCGGCATAAAGACAAACTTTTAGGTGAGCGACTACGACTGGCCCTGCAAGAACTGGGGCCGGTTTGGATCAAGTTCGGGCAAATGTTATCAACCCGCCGCGATCTTTTTCCACCGCATATTGCCGATCAGCTGGCGTTATTGCAGGACAAAGTTGCTCCGTTTGATGGCAAGCTGGCGAAGCAGCAGATTGAAGCTGCAATGGGCGGCTTGCCGGTAGAAGCGTGGTTTGACGATTTTGAAATCAAGCCGCTGGCTTCTGCTTCTATCGCCCAGGTTCATACCGCGCGATTGAAATCGAATGGTAAAGAGGTGGTGATTAAAGTCATCCGCCCGGATATTTTGCCGGTTATTAAAGCGGATCTGAAACTTATCTACCGTCTGGCTCGCTGGGTGCCGCGTTTGCTGCCGGATGGTCGCCGTCTGCGCCCAACCGAAGTGGTGCGCGAGTACGAAAAGACATTGATTGATGAACTGAATTTGCTGCGGGAATCTGCCAACGCCATTCAGCTTCGGCGCAATTTTGAAGACAGCCCGATGCTCTACATCCCGGAAGTTTACCCTGACTATTGTAGTGAAGGGATGATGGTGATGGAGCGCATTTACGGCATTCCGGTGTCTGATGTTGCGGCGCTGGAGAAAAACGGCACTAACATGAAATTGCTGGCGGAACGCGGCGTGCAGGTGTTCTTCACTCAGGTCTTTCGCGACAGCTTTTTCCATGCCGATATGCACCCTGGCAACATCTTCGTAAGCTATGAACACCCGGAAAACCCGAAATATATCGGCATTGATTGCGGGATTGTTGGCTCGCTAAACAAAGAAGATAAACGCTATCTGGCAGAAAACTTTATCGCCTTCTTTAATCGCGACTATCGCAAAGTGGCAGAGCTACACGTCGATTCTGGCTGGGTGCCACCAGATACCAACGTTGAAGAGTTCGAATTTGCCATTCGTACGGTCTGTGAACCTATCTTTGAGAAACCGCTGGCCGAAATTTCGTTTGGACATGTACTGTTAAATCTGTTTAATACGGCGCGTCGCTTCAATATGGAAGTGCAGCCGCAACTGGTGTTACTCCAGAAAACCCTGCTCTACGTCGAAGGGGTAGGACGCCAGCTTTATCCGCAACTCGATTTATGGAAAACGGCGAAGCCTTTCCTGGAGTCGTGGATTAAAGATCAGGTCGGTATTCCTGCGCTGGTGAGAGCATTTAAAGAAAAAGCGCCGTTCTGGGTCGAAAAAATGCCAGAACTGCCTGAATTGGTTTACGACAGTTTGCGCCAGGGCAAGTATTTACAGCACAGTGTTGATAAGATTGCCCGCGAGCTTCAGTCAAATCATGTACGTCAGGGACAATCGCGTTATTTTCTCGGAATTGGCGCTACGTTAGTATTAAGTGGCACATTCTTGTTGGTCAGCCGACCTGAATGGGGGCTGATGCCCGGCTGGTTAATGGCAGGTGGTCTGATCGCCTGGTTTGTCGGTTGGCGCAAAACACGCTGATTTTTTCATCGCTCAAGGCGGGCCGTGTAACGTATAATGCGGCTTTGTTTAATCATCATCTACCACAGAGGAACATGTATGGGTGGTATCAGTATTTGGCAGTTATTGATTATTGCCGTCATCGTTGTACTGCTTTTTGGCACCAAAAAGCTCGGCTCCATCGGTTCCGATCTTGGTGCGTCGATCAAAGGCTTTAAAAAAGCAATGAGCGATGATGAACCAAAGCAGGATAAAACCAGTCAGGATGCTGATTTTACTGCGAAAACTATCGCCGATAAGCAGGCGGATACGAATCAGGAACAGGCTAAAACAGAAGACGCGAAGCGCCACGATAAAGAGCAGGTGTAATCCGTGTTTGATATCGGTTTTAGCGAACTGCTATTGGTGTTCATCATCGGCCTCGTCGTTCTGGGGCCGCAACGACTGCCTGTGGCGGTAAAAACGGTAGCGGGCTGGATTCGCGCGTTGCGTTCACTGGCGACAACGGTGCAGAACGAACTGACCCAGGAGTTAAAACTCCAGGAGTTTCAGGACAGTCTGAAAAAGGTTGAAAAGGCGAGCCTCACTAACCTGACGCCCGAACTGAAAGCGTCGATGGATGAACTACGCCAGGCCGCGGAGTCGATGAAGCGTTCCTACGTTGCAAACGATCCTGAAAAGGCGAGCGATGAAGCGCACACCATCCATAACCCGGTGGTGAAAGATAATGAAGCTGCGCATGAGGGCGTAACGCCTGCCGCTGCACAAACGCAGGCCAGTTCGCCGGAACAGAAGCCAGAAACCACGCCAGAGCCGGTGGTAAAACCTGCTGCGGACGCTGAACCGAAAACCGCTGCACCTTCCCCTTCGTCGAGTGATAAACCGTAAACATGTCTGTAGAAGATACTCAACCGCTTATCACGCATCTGATTGAGCTGCGTAAGCGTCTGCTGAACTGCATTATCGCGGTGATCGTGATATTCCTGTGTCTGGTCTATTTCGCCAATGACATCTATCACCTGGTATCCGCGCCATTGATCAAGCAGTTGCCGCAAGGTTCAACGATGATCGCCACCGACGTGGCCTCGCCGTTCTTTACGCCGATCAAGCTGACCTTTATGGTGTCGCTGATTCTGTCAGCGCCGGTGATTCTCTATCAGGTGTGGGCATTTATCGCCCCAGCGCTGTATAAGCATGAACGTCGCCTGGTGGTGCCGCTGCTGGTTTCCAGCTCTCTGCTGTTTTATATCGGCATGGCATTCGCCTACTTTGTGGTCTTTCCGCTGGCATTTGGCTTCCTTGCCAATACCGCGCCGGAAGGGGTGCAGGTATCCACCGACATCGCCAGCTATTTAAGCTTCGTTATGGCGCTGTTTATGGCGTTTGGTGTCTCCTTTGAAGTGCCGGTAGCAATTGTGCTGCTGTGCTGGATGGGGATTACCTCGCCAGAAGACTTACGCAAAAAACGCCCGTATGTGCTGGTTGGTGCATTCGTTGTCGGGATGTTGCTGACGCCGCCGGATGTCTTCTCGCAAACGCTGTTGGCGATCCCGATGTACTGTCTGTTTGAAATCGGTGTCTTCTTCTCACGCTTTTACGTTGGTAAAGGGCGAAATCGGGAAGAGGAAAACGACGCTGAAGCAGAAAGCGAAAAAACTGAAGAATAAATTCAACCGCCCGTCAGGGCGGTTGTCATATGGAGTACAGGATGTTTGATATCGGCGTTAATTTGACCAGTTCGCAATTTGCGAAAGACCGTGATGATGTTGTAGCGTGCGCTTTTGACGCGGGAGTTAATGGGCTACTCATCACCGGCACTAACCTGCGTGAAAGCCAGCAGGCGCAAAAGCTGGCGCGTCAGTATTCGTCCTGTTGGTCAACGGCGGGCGTACATCCTCACGACAGCAGCCAGTGGCAAGCTGCGACTGAAGAAGCGATTATTGAGCTGGCCGCGCAGCCAGAAGTGGTGGCGATTGGTGAATGTGGTCTCGACTTTAACCGCAACTTTTCGACGCCGGAAGAGCAGGAACGCGCTTTTGTTGCCCAGCTACGCATTGCCGCAGATTTAAACATGCCGGTATTTATGCACTGTCGCGATGCCCACGAGCGGTTTATGACATTGCTGGAGCCGTGGCTGGATAAACTGCCTGGTGCGGTTCTTCATTGCTTTACCGGCACACGCGAAGAGATGCAGGCGTGCGTGGCGCATGGAATTTATATCGGCATTACCGGTTGGGTTTGCGATGAACGACGCGGACTGGAGCTGCGGGAACTTTTGCCGTTGATTCCGGCGGAAAAATTACTGATCGAAACTGATGCGCCGTATCTGCTCCCTCGCGATCTCACGCCAAAGCCATCATCCCGGCGCAACGAGCCAGCCCATCTGCCCCATATTTTGCAACGTATTGCGCACTGGCGTGGAGAAGATGCCGCATGGCTGGCTGCCACCACGGATGCTAATGTCAAAACACTGTTTGGGATTGCGTTTTAGAGTTTGCGGAACTCGGTATTCTTCACACTGTGCTTAATCTCTTTATTAATAAGATTAAGCAATAGCATGGAGCGAGCCTCACCATCGGGTTCGGTGAAAATGGCCTGAAAGCCTTCGAACGCGCCTTCGGTAATAATCACCTTATCACCCGGATAAGGGGTTGCCGGATCGACAATGTCTTTCGGTTTATATACCGATAGCTGATGAATAACCGCCGATGGGACTATCGCTGGCGACGCGCCAAAGCGCACGAAGTGGCTGACACCGCGGGTCGCGTTGATAGTCGTGGTATGAATCACTTCTGGGTCAAATTCCACAAACAGGTAGTTGGGGAACAATGGCTCACTGACTGCAGTACGTTTTCCACGCACGATTTTTTCCAGGGTGATCATCGGTGCCAGGCAATTCACAGCCTGTCTTTCGAGGTGTTCCTGGGCACGTTGAAGTTGCCCGCGCTTGCAGTACAGTAAATACCAGGATTGCATAATGACTCTTATCCGTTTAATCGGGGCGCAAGGATAGCAAAAGCTTTACGCTAAGTTAATTATATTCCCCGGTTTGCGTTATACCGTCAGAGTTCACGCTAATTTAACAAATTTACAGCATCGCAAAGATGAACGCCGTATAATGGGCGCAGATTAAGAGGCTACAATGGACGCCATGAAATATAACGATTTACGCGACTTCTTGACGCTGCTTGAACAGCAGGGTGAGCTAAAACGTATCACGCTCCCGGTGGATCCGCATCTGGAAATCACTGAAATTGCTGACCGCACTTTGCGTGCCGGTGGGCCTGCGCTGTTGTTCGAAAACCCTAAAGGCTACTCAATGCCGGTGCTGTGCAACCTGTTCGGTACGCCAAAGCGCGTGGCGATGGGCATGGGGCAGGAAGATGTTTCGGCGCTGCGTGAAGTTGGTAAATTATTGGCGTTTCTGAAAGAGCCGGAGCCGCCAAAAGGTTTCCGCGACCTGTTTGATAAACTGCCGCAGTTTAAGCAAGTATTGAACATGCCGACAAAGCGGCTGCGTGGTGCGCCCTGCCAACAAAAAATCGTCTCTGGCGATGACGTCGATCTCAATCGCATTCCCATTATGACCTGCTGGCCGGAAGATGCCGCGCCGCTGATTACCTGGGGGCTGACAGTGACGCGCGGCCCACATAAAGAGCGGCAGAATCTGGGCATTTATCGCCAGCAGCTGATTGGTAAAAACAAACTGATTATGCGCTGGCTGTCGCATCGCGGCGGCGCGCTGGATTATCAGGAGTGGTGTGCGGCGCATCCGGGCGAACGTTTCCCGGTTTCTGTGGCGCTGGGTGCCGATCCCGCCACGATTCTCGGTGCAGTCACTCCCGTTCCGGATACGCTTTCAGAGTATGCGTTTGCCGGATTGCTACGTGGCACCAAGACCGAAGTGGTGAAGTGTATCTCCAATGATCTTGAAGTGCCCGCCAGTGCGGAGATTGTGCTGGAAGGGTATATCGAACAAGGCGAAACTGCGCCGGAAGGGCCGTATGGCGACCACACCGGTTACTATAATGAAGTCGATAGTTTCCCGGTATTTACCGTGACGCATATTACCCAGCGTGAAGATGCGATTTACCATTCCACCTATACCGGGCGTCCGCCAGATGAGCCCGCGGTGCTGGGTGTCGCACTGAACGAAGTGTTTGTGCCGATTCTGCAAAAACAGTTCCCGGAAATTGTCGATTTTTACCTGCCGCCGGAAGGCTGCTCTTATCGCCTGGCGGTAGTGACAATCAAAAAACAGTACGCCGGACACGCGAAGCGCGTCATGATGGGCGTCTGGTCGTTCTTACGCCAGTTTATGTACACTAAATTTGTGATCGTTTGCGATGATGACGTTAACGCACGCGACTGGAACGATGTGATTTGGGCGATTACCACCCGTATGGACCCGGCGCGGGATACTGTTCTGGTAGAAAATACGCCTATTGATTATCTGGATTTTGCCTCGCCTGTCTCCGGGCTGGGTTCAAAAATGGGGCTGGATGCCACGAATAAATGGCCGGGGGAAACCCAGCGTGAATGGGGACGTCCCATCAAAAAAGATCCAGATGTTGTCGCGCATATTGACGCCATCTGGGATGAACTGGCTATTTTTAACAACGGTAAAAGCGCCTGATGCGCGTTTGTTTTGCCCTATTTATCGATCCGACAGAGAAAGCGCATGACAACCTTAAGCTGTAAAGTGACCTCGGTAGAAGCTATCACGGATACCGTATATCGTGTCCGCATCGTGCCAGACGCGGCCTTTTCTTTTCGTGCTGGTCAGTATTTGATGGTAGTGATGGATGAGCGCGACAAACGTCCGTTCTCAATGGCTTCGACGCCGGATGAAAAAGGGTTTATCGAGCTGCATATTGGCGCTTCTGAAATCAACCTTTACGCGAAAGCAGTCATGGACCGCATCCTCAAAGATCATCAAATCGTGGTCGACATTCCCCACGGAGAAGCGTGGCTGCGCGATGATGAAGAGCGTCCGATGATTTTGATTGCGGGCGGCACCGGGTTCTCTTATGCCCGCTCGATTTTGCTGACAGCGTTGGCGCGTAACCCAAACCGTGATATCACCATTTACTGGGGCGGGCGTGAAGAGCAGCATCTGTATGATCTCTGCGAGCTTGAGGCGCTTTCGTTGAAGCATCCTGGTCTGCAAGTGGTGCCGGTGGTTGAACAACCGGAAGCGGGCTGGCGTGGGCGTACTGGCACCGTGTTAACGGCGGTATTGCAGGATCACGGTACGCTGGCAGAGCATGATATCTATATTGCCGGACGTTTTGAGATGGCGAAAATTGCCCGCGATCTGTTTTGCAGTGAGCGTAATGCGCGGGAAGATCGCCTGTTTGGCGATGCGTTTGCATTTATCTGAGATATAAAAAAACCCGCCCCTGACAGGCGGGAAGAACGGCAACTAAACTGTTATTCAGTGGCATTTAGATCTATGACGTATCTGGCAAACCATGCCCGATGCGACGCTGTCGCGTCTTATCGTGCCTACAAATAGTCCGAACCGTAGGCCGGATAAGGCGTTTACGCCGCATCCGGCAATTGGTGCATGATGCCTGATGCGACGCTGGCGCGTCTTATCAGGCCTACATTGGTGCCGGATCGGTAGACCGGATAAGGCGTTCACGCCGCATCCGGCAAGTGGTTAAACCCGCTCAAACACCGTCGCAATACCCTGACCCAGACCGATACACATCGTCGCCAGACCAAACTGAACGTCTTTGCGTTCCATCAGATTCAGCAGCGTGGTGCTGATACGCGCACCGGAACAACCCAGCGGATGACCCAGCGCGATCGCGCCACCGTTGAGGTTGATCTTCTCGTCAATCTGCTCAATTAGTCCCAGATCTTTAATACATGGCAGGATCTGCGCGGCAAAGGCTTCGTTCATTTCAAACACGCCGATATCGCTGGCAGAAAGCCCCGCTTTTTTCAGCGCCAGTTTCGAGGCCGGAACCGGGCCGTAACCCATAATCGATGGGTCACAACCAACGACCGCCATCGAACGCACACGAGCGCGCGGCTTAAGACCTAATTCATGGGCGCGGCTTTCACTCATCACCAGCATGGCAGCTGCGCCATCGGAAAGTGCAGAAGATGTGCCCGCCGTTACCATACCGTTTACTGGATCAAACGCCGGACGCAGCGTGGCGAGGGCTTCCACGGTGGTTTCCGGGCGAATCACTTCGTCGTAATTAAACTGCTTCAGGACGCCGTCGGCATCGTGACCACCGGTCGGGATGATTTCATTTTTAAATGCGGCCGACTGCGTGGCGGCCCAGGCGCGGGCGTGTGACCGCGCGGCAAAGGCATCCTGCATTTCACGGCTGATACCGTGCATACGCGCCAGCATTTCTGCCGTTAAGCCCATCATGCCCGCCGCTTTGGCGACATTGCGGCTCAGGCCGGGGTGAAAATCGACGCCGTGACTCATCGGCACATGGCCCATATGCTCCACGCCGCCAACCAGACATGCCTGCGCATCGCCAGTCATGATCATTCGTGCTGCGTCATGCAGTGCCTGCATGGATGAACCACACAAGCGATTAACGGTAACCGCCGGGACAGAGTGTGGTACTTCTGCCAGCAGCGCCGCGTTACGGGCGATATTAAAACCCTGCTCCAGCGTCTGCTGCACACAACCCCAGTAAATATCGTCGAGGGCCGCCGCTTCCAGCGCCGGGTTACGCGCCAGCAGGCTACGCATTAAATGAGCGGAGAGATCTTCTGCACGCACGTTACGAAAAGCACCGCCCTTCGAACGGCCCATCGGGGTGCGAATTGCATCGACAATGACAACCTGTTCCATTGTGACTCCTTAAGCCGTTTTCAGGTCGCCAACCGGACGGGCTGGCTCAACCGGAGGATAGTACGGTTCGTTATGACGCGCTTTATTACGCAGACCTTCCGGCACTTCATACAGCGGGCCGAGGTGCTGATATTGCTGTGCCATATCGAGGTATTTTGCGCTACCGAGGGTGTCCAGCCAGCGGAACGCGCCGCCGTGGAACGGAGGGAAGCCCAGGCCGTAGACCAGCGCCATATCCGCTTCCGCCGGAGTGGCGATAATGCCTTCCTCCAGACAGCGCACCACTTCGTTGACCATCGGGATCATCATGCGGGCGATAATCTCTTCTTCGCTGAAATCGCGCTTCGGCTGGCTCACTTCTGCCAGCAGGTCTTCAACGGCGGCGTCTTCTTCTTTCTTCGGCTTACCTTTGCTGTCTTCTTTATAACGCCAGAAACCGAGGCCGTTCTTCTGACCAAAGCGGTTGGCATCAAACAGCGCGTCGATGGCATCGCGGTAATCTTTCTGCATCCGCTGCGGGAAGCCTGCTGCCATGACAGCCTGAGCGTGATGCGCGGTATCAATGCCCACAACGTCCAGCAGATATGCCGGGCCCATCGGCCAGCCAAACTGTTTTTCCATCACTTTGTCGATCTTGCGGAAATCCGCGCCGTCGCGCAGCAGCTGGCTGAAACCGGCGAAATACGGGAACAGCACGCGGTTAACAAAGAAGCCGGGGCAGTCGTTAACCACAATCGGCGTCTTGCCCATCTTGCTCGCCCAGGCGACAACTTTCGCGATGGTTTCGTCGGAGCTTTTCTCGCCGCGAATAATTTCTACCAACGGCATTCGGTGGACCGGGTTAAAGAAGTGCATCCCGCAGAAGTTTTCCGGGCGTTCCAGCGCGTTGGCCAGTTCGCTGATAGGAATGGTTGAAGTGTTAGACGCCAGCACGGTATCCTGGCGTACTTTTTGTTCGGTTTCTGCCAGTACGGCTTTTTTCACTTTCGGGTTTTCAACAACCGCTTCTACCACAATATCCACGCGGTCAAATCCGGCGTAGTCGAGCGTTGGGTGGATTGTGGAGATCACGCCAGCCAGTTTCAGACC
+>7_2#NODE_1_length_40000_cov_62.8079_ID_1
+TGTTATGGCTCAAGCTGTTAAAAGAATTTATAAGGATTCAAAGCTTGCTATAGGACCTGCAATAAATAATGGTTTCTATTATGATTTTGATATTGAAAACTCATTATCCAATGAAGATTTAGATAAAATTGAAGCAGAAATGAATAAAATAATAAATGAAAATCTTAGCTTTGAAAGAATCGATATTTCTAGAGACGAAGCAATAAAATTAATGGAGGAAAAGGGAGAAACATATAAAGTAGAACTTATTAAGGATCTTCCAGAAGCTGAAAAGATATCTTTATATAAACAGGGCGATTATATAGATCTTTGCAGAGGTCCTCATATTCCATCAACAAAGTATATTAAAGCATTTAAACTATTAAGCGTTGCTGGAGCATATTGGAGAGGAAATGAAAAAAATAAGATGCTTCAAAGAGTTTATGGAGTTGCATTTTCTAGTAAGAAAGAATTAGAATTACATTTGCATAATTTAGAAGAAGCAAAGAAAAGAGATCATAGAAAATTAGGAAAAGAATTAAAGTTATTCACTTTTGCAGAAGAAGGTCCAGGATTTCCATTTATGCTTCCTAAAGGAGTAATATTAAAAAATACCCTAATAGATTTTTGGAGAAAATTACATTACGAAGATGGTTATGTTGAAATTGAAACTCCAATAATGCTTAATAAGAAACTATGGGAGACTTCAGGGCATTGGTATCATTATAGAGAAAATATGTATACTTCAACAATTGATGAAGAAGAATTTGCATTAAAGCCAATGAATTGCCCAGGTGGAATGTTAGTTTATAAATCAGAATCACATTCATATAGAGATTTTCCAATGAGAGTTGGAGAACTGGGACGAGTTCATAGACATGAGCTTTCTGGAGCACTCCATGGTCTTATGAGAGTAAGAGCATTCACACAAGACGATGCACATATATTTATGTTACCAGATCAAATAAAGTCAGAAATAAAAGGTGTTATTAATTTAATTGACAAGGTATATTCAAAATTCAGATTTAAGTACAATTTAGAACTTTCTACAAGGCCAGAGGATTCAATGGGAAGCGATGAAGAATGGGAATTAGCAGAAAGCTCATTGAAGGGTGCCTTAGATGAATTAAATCTTGAATATAAAATAAATGAGGGTGACGGAGCTTTTTACGGACCTAAAATAGATTTTCATCTTGAAGATAGCATAGGCAGAACTTGGCAATGTGGAACAATTCAGTTAGATTTTCAATTGCCTCAAAGGTTTGAGTTAGAGTATGTAGGTAGTGATGGAGAAAAGCATAGACCAATAGTAATCCATAGAGTAGTCTTTGGAAGTATAGAAAGATTTATAGGAATATTAATAGAACATTTTGCTGGAAAATTCCCAACATGGCTTTCTCCAGTTCAAGTAAAAATACTTCCTATATCAAATAAATTTAATAGCTATTCAGAAAAGATTAAGGATAAATTAAGCTCAGAAGGTATAAGAGTTGAAATTGATCAGAAAGATGAAAAGATAGGCTATAAAATAAGAGAAGCTAGAAATGAGAGGGTTCCTTACATTATTATTGTTGGAGAAAAGGAAGAAGCAGAAAATAATATATCATTACGCAGCAGAAGTAATGGCGATGAGGGAACATTAAATTTAGAAGATTTAATAGAAAGAATAAATAATGAAGTTAAAAATAAAGCTCTATAATTAAGTAGAGATAATACTGAAATATTAAGATATTAAATTTAAGGAATAATTAAAGTAAATATCACTTTAATTATTCCTTTTAATATTGTATATGGACAACATCATCGAAATTTAAAATATTATTTTAAATTTCTGCAGTTTTTAATTTATTAAACAAGCAGTTATATATTATAATGTTATATATCACTTGATGAAGGAGAAGGAAAATATGTTTTTATTTGGCGGGAATAAATTAAAGGTAAGAAGCGAAGAAGATGAGGATGGAGTTAAAACTTTCGTGGAATACTATGGAATGAAGAAAAGCGATGAATTTAAAGTAAAGGTTTTAAATGAAATGATTGGAGAAAACCTTTGTTTAATAGTTTTAGACTCTAGAATGTTGTATTTTGGAAATCAAGTGGAACATGAGGTGCCAGTTGAAGAAATAATAGAGCATTTAGGAATTTCAAGAATAGCATATAAGAAGTTTGAAATAAAGAAGGTACCAGAAGTATCTATGTTTGGTATTAGCATAAAAAAGGGAACTAAAAAAACTGATAAAGATTATGTAATAGGATTTGTTGTAAATAAGTATAATTTTAAAAGAATTGAAGAATATGTAAATAGAATGAATCTATATTATTTCATAGATAACGCTGGACTTAGTGAAGAGGATTTATTACAGAAGTTGAGTGAAAATTATGAAGAAATTGATGAAATGAGTAAGGAATTTTACTGTGAGATATTTAATAATAATTACATAAGTCAGTTAGTTATTTCATCAGAAAATGAGAACGCTATGGCAATAAAGGAAACGGTTGGCAGGTGCCATTCTGAGTTAAAATAAATAGTTTCACTCTAAGAAGAATGTATGCAAATTTTATTATTTATTAATTTACTAGTGAATTCAACGTCTAATAGAATTAGCAAACATTCTTTTGCCTTGACAACATTATTAGATTATGGAATGATAATTAGATGTCGGAAAACTACTAATTGATTAATTATTTTACAAATGAAAAATTAGTTGAGATTAAAAAATGATATAAATATTATCTAGATTAAATATGAGGGAGGTATAGGAATACTTTTTTGATAGAATTATTTCTATGCGTTTTTTTGAAGCTTAACAAATTGCAAGTTTAATCTATATAATAGTAGCATACTGAAAATTTTTTAGAAAAGGTTAATGAGTAGTATGAAGAGAATAAATGAAGCTTTTAGTGATTATGAATCGGCTGGCAGCATAAATACTGCCGTTATACAATCCGTAGTCTTGCGTAAGAAAACTAAAGTGCTGGAAATGGAAATTAGTTCAGATAATTATATTGAACTAGGGGAAATTGAAAGTTTTAATAGTTTCATAAAAGATAAATTCGGATTAAATGATTCTAAAATTATTGTAAAGTATAGTGACGAGGTTGAAATAAGACCTATAGAAAAAGAATTGAAAAATATCGTATATTCCTTATCTACAAAGTATCCTGCATTAAAGGCAGCGGTTAATAATAGTGACTATGAAATAGAAGGAAATACTATAAATTTTAATTTTAAAATTCCTGTAGCGGGTTTTCTAAAAACTATGGAATATGATAAGCAAATTAATAAAGCTATAAAACATATGTATGGGAAACATTATAATATCAATTTTATTGATCAAATAGATAGCGAAGAATTGGTGAAAATCGCAGAAGATAAACGTGCTAATGAGATGAAAGTTATTAAAGAAATAAAAATTACTCAAAGCAATAATCCTCCTGAAGTACCTAAAGTTGAAGAAGGTAAGGCAGAAGTAAAAGCTGAGGGCGATGGCAAAAAGGCAAGTAATCCATTCTTGATTTTAGGAAGAAATGCTAATATTAAGGAAAACATAATTAAAATTAATGATATTACACCTGATGAAGGAAGAGTGGCTTTAGAAGGTGAAATATCAAATTTAGAAGCAAAAGAATTAAGAAGTGGAAAAATGCTAATTTCCTTTGATTTATATGATGGATCAAATTCGATGACTTGTAAGATTTTTGCAAAACCTAATGAGTATAATGAAGTGTTTTCTAGAATTAAAAAGGCTAAGGGTCTTAGACTTGCTGGAAATGCAGGCTATAGTAATTTCTCTCATGAAGTTGAACTTATTGCTAATACTGTTATTGAAACAAATGGTATAAGGAGATATAAGAGGCAGGATAATTCAGAGGTGAAGAGAGTAGAGCTTCACATGCATACTCAAATGAGCCAGATGGATGCAATGTCTAGTGCTAGTGATTTAATTAAGAGAGCTATGAGCTGGGGAATGAAGTCTATTGCTATAACTGATCATGGAGTAGTTCAGTCATTTCCAGAAGCGCACAAATTGCTTGGAAGAGATAATCCAGATATGAAAGTCATATATGGAGTTGAAGCTTATCTAGCTCCAGATAAAAAGCCATCTGTAACAAATGTTAGGGAAGAAAGTATTGATACAGTATACTGTGTTCTTGATTTAGAAACTACAGGTTTTTCTCCTCAGACAGAAAAGATTACTGAAATAGGAGTAATGAAAATTAAGGATGGTAAGGTTATAGATAAGTTCAGTACTTTTGTAAACCCTCAAAAGTCAATTCCTATGAGAGTTGTAGAGGTTACAAAGATAACTGATGATATGGTAAAAAATGCAGAAACTATTGATAAAGTTTTCCCTAAATTGCTTGAATTTATTGAAGGAAGTGTTTTAGTTGCACATAATGCTGACTTTGATATTGGATTCTTAAAGCATAATGCGAAAGTTTTAGGCTATGAGTTTGATTTTACCTATATAGATACTTTAGGATTAGCGCAAGATGTATTCCCTGATTATAAATCTTATAAGCTAGGAAGAATTGCTAAAAATCTTGGAATAAAGGTTGAAGTTGCCCATAGAGCTTTAGATGATGTTGATACAACTGTTAAGGTATTTAACATAATGATTGAAAAGCTAAAAGAAAGAGGCGCGCAAACTTTATCAGATATAGATTTATATGCAGCCGATGAAGAAGCTAAGAAAGTGGCATATAAAAAGGTTAAAACTCACCATGCAATAATACTAGCAAAAAATTACGTGGGATTAAAGAATTTATATAAATTGGTATCATATTCTCATTTAGATTATTTTTATAAAAAGCCACGTATATTAAAGAGCATGTTTAAGAAATATTCTGAAGGTTTAATTATTGGAAGTGCTTGTAGTGAAGGGGAATTATATCAAGCCATACTTCTTGGAAAACCAGAAGAACAAATTGAGGAAATTGCTAATTTCTATGATTACTTAGAAATTCAGCCTTTAGGAAATAATGATTACTTAGTAAGACAGGAGCAAGTTCCAAGTAAAGAATATTTAAAAGAAATTAATAAAAAGATCGTAGAACTTGCAGAAAGATTAGGTAAGCCTGTAGTGGCTACTGGAGATGTTCACTTCCTAGATCCTGAAGATGAAATATACAGACGTATATTAGAAGCAGGACAGGGATTTAAGGATGCAGATAATCAAGCACCATTATATTTAAGAACTACTGAAGAAATGCTCGATGAATTCTCTTATTTAGGAAGAACAAAAGCTTATGAGGTTGTAGTTACAAATACTAATATAGTAGCAGATATGTGTGAGCAAATAAGCCCTATTTCTCCTGAAAAATGTCCACCTCACATAGAAGGCTGTGAGCAGACAATAAAAGATATAGCTTATGAAAAAGCCCATGAACTTTATGGAGATCCACTTCCAGAAATAGTTCAGGCGAGACTTGATAAAGAGCTAGATTCTATTATAAAAAATGGATTCTCAGTAATGTATATCATAGCTCAGAAGCTGGTATGGAAATCAAATGAAGATGGATACTTAGTAGGTTCCAGAGGATCTGTTGGTTCATCCTTCGTTGCAAATATGACTGGTATAACAGAAGTAAATGCGCTTCCACCTCATTACAGATGCCCTAAATGTAAGTATTCTGATTTTGAGGATTATGGCGTTCTAAATGGCTTTGACTTGCCAGATAAAGTATGTCCTGTTTGTGGAGAAAATCTGTATAAAGATGGTATAGATATTCCGTTTGAAACATTCCTGGGCTTTAATGGAGATAAAGAGCCGGATATAGATTTAAACTTCTCAGGGGAATATCAGGCAAAGGCCCATAGATATACAGAAGTTATCTTTGGAAAGGGAACAACATTTAAAGCAGGGACTATTGGTACTATAGCAGAAAAAACAGCGTTTGGTTATGTTAAAAAATATTATGAAGAAAAAAATATTACAATAAACAAAGCTGAAACAATAAGAATTTCAGTAGGGTGCACTGGTATAAAGAGAACTACAGGTCAGCATCCAGGAGGAATTATAGTTGTACCAAAGGGAAGAGAAATATTTGAATTCTGCCCTGTACAGCATCCTGCGGATGACCCTAACTCAGATATTATAACAACACATTTTGATTATCACTCTATTGACCAAAATCTATTGAAGCTTGATATACTAGGGCACGATGATCCGACGGTTATAAGAATGCTTCAAGATATAACAGGGGTTGACCCACATGAGATTCCTATGGATGACAAGGATACTATGTCCTTATTCTTCTCAACAAAGGCTCTTGGGGTAACTCCAAATCAGATAAATTCAGAGGTTGGAACCTTTGGAATTCCTGAGTTTGGTACTAAGTTCGTAAGAGGAATGCTTGTGGATACAAAACCAAAGACTTTTTCAGATTTATTATGTATATCAGGACTTTCACATGGTACAGATGTATGGCTTGGAAATGCTAAGGACTTAATTGATAATGGAGTAATTACCAGCATAAGTGATGCGGTATGTACCAGAGATGATATTATGGTTTACTTAATTAGAAAAGGACTTCCACCTAATACCGCGTTTAAAATAATGGAAACTGTTCGTAAAGGTAAAGCCTTAAAAGAACCTAAATTTCCAGAATATGAAGCTATGATGAGAGAACATGATGTACCAGAATGGTATATAGAGTCTTGTAAAAAGATAAAATACATGTTCCCTAAAGCCCATGCAGCAGCTTATGTAATGATGGCATTTAGAATAGCATGGTTTAAAGTTCATATACCTCAGGCTTATTATGCAACATACTTTACTATAAGAGCAAAAGCCTTTGATGCAGAATTTATGATCTTTGGAAAAGAAAAGGTTAAAGCAAAGATGCAGGAAATTCAGGCTCTTGGAAATGAGGCTGGTCCTAAGGATAAGGATATGTATGATGACCTTGAAATAGTTTTGGAAATGTATGAAAGAGGATTTAAATTCCTTCCAATTGATTTATATAAATCTAGTGCTACAAAATTCCAGTTAGAAGAAGAGGGAATAAGACCGCCATTAAACAGTATAGCAGGTATGGGAAATGTAGCTGCAGAAGGTATAGCAAGTGCAGCAAAAGAAAAAGAATTTAATTCTGTAGATGATGTAAAGAAACGTTCAAAGATTGGAAATGCTGCCATAGAGCTACTTAGAAAATTTGATTGTTTAAATGGTCTTCCAGAAAGTGATCAAATGAGCTTCTTTGACGCAGTTTAGATTTATGACTATAGATAAAATAACTTTGAAACTAAACTTAAGTGGTAACTTACCGAAATCATAAATATTTTGTTCCGAAAAACTATGAAAATATTGCTGAAAATCCTAAGTTGCAGATTGCACCACTTCAGCATGCTCCCACTTTCAGTGTGACAAGCAAAAGTGGAACAACCTACAACTAAGAATTTTTAGCAGCTCATTTTCAAATGTTTTCTGCACAAATATATTTATGATTTCTAGTGAAGATATTACCTCAAAGTTTTAGCAAGTTTGTAAATATGTTTATATTATAGATTTAAATATTAATTTTGATATTATAGATAAACTAACTAAGATCTGAACTGGAGTATTCTCTCTTTATAGTATGGTCTAAATTATAAGTGGAATTTAGATTTTCTAGTGAAGTTGTACTTTTATTTTATTAAGTATTTTAAAATTTGAACTTAAAAATTATATAAAAAATAACGTAAAAAACACAGCCTAGTGATTAAATATATAGGCTGTGTTTTTTGTTATATATTTATTGTTAATTTAGTTATAGTATATTTAAGTAAAATAGATTATTTTCCATTATCTGTTGAGCCAACTTGATTGTTGCCTTTATCACGATTATTCTTGCCTTTCATCTTATCAACATTGCTCTTATCATTCTTATTTCTATTGTATTGAGAAGATCCCATTTTATATCACCACCTTACTTTTTATTTATTATTCGCGGAAAGAGTTTGTGATATTCATATTGAGATTAGTTTTTCGCTCTTTTCGTAAATATTGTGGGCAAATATAAAATTAGATTTTGAGCAAATAATCATTTTCTGTTTTCAAAATGCTCAATTCTAATATAATAATATTTGACATTTATAACTATAAGTATATAAACTTAAAACAAATAAGGTTATATACATTATATTTACAATTAGGAGGAATAGATTATGGCAAAACTATTAGATAATGAATATTCAATGGTATCATTTAAGGCTCGTAAAGGAGATAAGGAAGCCAGGAGAAACACAATTATAAATATTATATTAAATATTTTTGTATTAGAAGGTAAAGGTAGCAGTGGTACTAAGGAATTTATGTTTACACTTACAAATAATCATCTATACATAGATGATATTGGGTACGATTTAACTGGTCAGGTAGACATCTATCTCACAGAAAAATTTGATAGAAAAGATATAAAATCTTTTAAGGTTAGAAAAGAAGGCAATAAAGAAATAATCTCTCTTGTAACCACTAATGGCAAAACTGTAACTTATGTAAGGGACAATGAAAACGCTTCAGATTTAGCAACAGAAATGGCTAAACTAATAATTGAAAATGCAGGAAATTAAATAATATTCAATAGTCAAAGGGGGTGCTTAGATAACTCCCTTTTAAATATTGTTATATTTTTCACTATAATACATTAATAGGGTGTAAATCCTTAATAATTATTGATTTATTCATTGCGAGTACGTTTGTCAGTAAAGTTTTCTTCAACTCAACTTTATCAAGTGATTTATTTAGTTCAAGAAATCTATGCCAAAATAAATAATTATCCATATATTTAGTTGATACACCATTAAAGTGAAGATTAATCCACTTTCCAAGCCTTTTATGATATTCATTAACATGTTGCATATGATATAATTTTTCGATTACATATTGTTTTTTAGAAGCATTTACTTGCTTATGCTCTAAACCCTTCATTTTTGCAAATGATAAATAATTCTTTGCCGAGTCACTTATTAATAAAGCATTAGGGGCAATATAATTGCCTATGACATTATCTATTTGTGTAGCAGTAATACGCCCCATACCAGCATTTCTACTAATTATGTGACCATTTCTATCCATAGCAACTAAAATACAAACCTGTTCATGGCTTATGCCTCTAAATTTAGATTTACCACCTCTTTTGTTGGGTTTGCGAGTTTTACATTGGTTTTTCCCTTTAAATGGCTCTATGAAGAAGGTTTCATCTGACTCAATGATACCAGACAATTGTTCTATATCCATTGAACGTAAAGAATTAAGCACTTTATGTCTCCAATAAAAGGCTGTTGAAATACTTATATTAAGAGCCTTTGCGATTTTGGGTAGAGTTGTTCCCTCTGATATAAATTGAAAATATTTAGCCCATTTTTGAGGATAATGTGTTCCTGCCATTGGACTACAAGATACATCATTAAAGGTTTTGCCACAATCTTTACATTTATAACGTTGTCGGCTACGATATTTTCCATGACCAATAATATGTTCACTATTACAATGAGGACAAAACGTACCCTTTGAAAAACGTGTTTCTCTAATGGTTTCTATATAATCATTAACTCTATCAGAACTGTTCTTAACAAGAGGATATATCAAGTTGAAAAACATATTTTGAACCACTGGTGATAACTTTTGAAATTCATCAAATAAGATATTTATATCCATGAATGATATTCACTTCCAGAGCTGGTAAACTCAATAAAGTCATCTGACAGCATATCATTTATTTTATCTTCTGACTTTCTAACTTCTGATTTTAATAACTCATGTTCTAATTGTAATAGGTGATCTTTAATACTATTCGTGCATTCACCTCATCTTATGATATATATTTCAATATCAATCTTTCTATCAATAATGTTATTAATAATGAGTATTTAAATAATTTGCTATTTCTTCAATAAGTTCATTTCTATCTAAATCCAAAGCCATGATTGAGCAGCCATCCATATGATCGCAAGAGATATTGATTTTTAGTAATAGGAATTAAATTATGAAGAGGATTAAGACAAGTTTAGAATACATTTTTGTAAGTTCATAAGTATTGAAAAAGTAAACTATGATTTTTAGTTGTAATAATTTTAAAAAATAGGTTTACAATTTGAACTTAAAAATACTTAGAGTGTATATAAAGTAAAAATTTTCATGTTAAATTTTATATTCCAGATGAATTTAGTTAAACTTACCCCCACAAGGGGCACAATGTAGCCACAAGGTGAAAATGTCTGAGGATATATGTTATTAGCTGGTACTCCTCAGAAGTGATTGGAGTATTAGAATGGCTATATATCAGATGGATGTACATCCATGAGATTGATGCCCTCATGGAAAGATTAAAAAGGTTTAAAGTATTTCTTTTAAAGGAGAGTGAGAAACATGTCAGATATTAAATGGATTAAGTTATCTACTAACATGCATGATGATGAAAAGATGAAATTAGTAGATGCAATGCCAGAGAGATACTATTCATTATTTATGGATAAGATTACTTATACAAGCTGGCAAAACTAATGATAATGGACTTATATATCTAAATGAGAATATCCCATATACTGATGAAATGTTGTCTACAATATTCTCAAGGCCTCTAGCTTCTATTAGACTTGCACTTAAAGTATTATCAGATTTTCAAATGATTGAAATAGCTGAAAATAACGTAATTAGAATAGTGAATTGGGAGAAACACCAAAATGTTGAGGGAATGGACAGAGTTAGAGAGCAAAATAGAAAAAGAGTTCAAAACCATAGAGAAAAGAAAAAACAACTTGAAGCTGTAGTTAATGAAAGTGAAGAAACTAGTGTTGAAATTGAAGAACATAGCTTTGCTGAAATTGAAAAATATAGTATTGAAGTTACAAATGATATTTGTGATACTTCAAAAAAATCTTGTAGCGTTACAGATGATAAAAATAACGTTACTGTAACGGTGCAGAATAAGAGAGAGAATAAGAACAAGATTAAGAATGAGAATAATAAAGATAGAGAGATAAAGAAAGAAGAGAATACAGGTTATGATGCAAATGAAACTCCTACTTCTAATGCAGCGTACGTAAGTGATTTGCACAACAGACAAGCTTTTAGATCTCTGGTTAAGGAAACTTATATTCCTAATGCCATGGCAGTAAGTGATCCACATGAAACCACAGATTTTAGTTCTCTGCTTAAATCAGAATCAGCAAAGTCTTCTATCTCTCAATCTAAAGACTCAATTGCTGAGCAGGATAATAATTTAGAGGACATAAACTCTAAATCCATTGAACTTGCTAAGTATTGTGAACTAATAGCTGGAATACCTAATGTTCTTAATTTAGGCGCACTTAGGTTAGCTATAGGAATGCATGGTCAAGAATATGTAAAGATGGCTATAGATATAGCATTAAAAGCCAATAAACCTAATATGACCTACATTGATGGCATACTGAAAAATTGGAGAAGAGAAGAATATCCAGATGACAAGGAGGTAAACAAAAATGTCAATAGGAGCTATGGAAAGAATAGCAACTCAGATAAAAACAAATTTGCAGGATTCAAACCAAAGGAAACACGACGAAGCCTTACAGATGAGCAACGAAAGAAAGCTCTAGAAAACCTCATATAAGTGTGAGAAGTATTGAAATACTTCTTAGAAGAAAAGACAAGAGTAATTCAAGGCAAGAAATCATCTCAATATATTGTGGTTATGATGGCTTAGTAAATATATAAAATTTGAGATATACAAGAAATGATTTAATCATATAAAAGAAAATAATTTTGTATAGGGGAATGTAAAAATGAGAGCATCAGGAATAGTGAGAAAGCTTGATCCACTTGGAAGGATTGTAATACCAAAAGAAATAAGAAAGGTACTTGGAATTAATGATGGAGATTCTATGGAAATAATTAAAGTTGATAATGAGGTAGTTGTTAGGAAATATAGTAAAGGCTGCATATTTTGTGGAAATGATAAAGGGGTTTTTAACTTTAAAGATATACTGATTTGTAACGAGTGTAGGGAGGCATTAAAGGGAAATTAATTGAGAAAATTTAAGATGAGTTGATTAAGCTAAGCCATTAAATTTAAATTTTGAATATGTAAAGTTGACTTAGTAATAAATAAAAAAGATGGTCTTTGAAAATTTAATAATTCGATATTTACAGTTTATGCTATAATTGATTTATATTAGAAAAAGGCATGTGTTAAATAAAATAAATCGGAGAAGTAAAATGAAGAGATTAAAATTAAAAAAAGTAATATCTAGTTCATTATTAGTAATTTTAGTATTTGTATTAAATCCAATAGTTGTAAGTGCTGAATGGAAACAAGATTCTAATGGATGGTGGAATGCAGAAGGAAATTCATGGTCAGTAGGTTGGAAAGAGATTGATGGAAAGTGGTACTATTTTGGACAAGATGGATATATGAAAATGGGATGGATACAGTATGAAGATAAGTGGTATTACTTAGGTGATGATGGTGCTATGCTTAAAAATACTACTATTAACGGTTACAAATTAGATTCTGACGGAGTGTGGATTCAATCATCACAAAATGATTCATCAAATGTTGAGTCGAAAGATAAGAATGTAAGTTATGAAACCGAAGTAAGTAATAGAAAGCCAATTATCAAAGATGGAAACTATCTATATGAATCTGGTAATTTATCCAAAGTTAATATTGATGGAACAAATAAAACATACTTTGAGCAGGCATATGGAAGCATTATTGGCGTTTCTGATGGCTGGGTTTACTATGTTGATGGAAATACTGAACACCATGGCAGTAAAGGTATATACAAAATAAAGGATAATGAGAAAGTTAAGTTAACAAGTGAGGATTATATTGTTGATGCTGTCTTTTATAAAGGATCAATATATTATGCATTAGGACCTGAAATGGTTGAAAATAATGTGGTTAAGGGTGGATTATATAAAGTTGATATTGATGGAAAAAATAAAGTTCAACTTTCTGATCAGTTGGTTGAGAATATAAATATATATAAAGATTGCATATATTACAGCGGTACAAGCTCTGTTACTACTGATAATACAGTTAGCAACGAGAATTCAGGTATATTTAAAATGAACACTGATGGCACAAGCAGAACAAAAATCAGTGATCATTATGCTTCATTCTTAAAATTAAGTGGTAATAATATTTATTTTAGCAGTTTTGATTATAACTACAAATTATATAAGATTAGTATTGATGGGACAAATGAAAGAAAATTAAATGATGATATCAGCTGGGATATTCAAGTGGATGGAAATTGGGTATACTATAGTAATAATCCTTACGATGGGCATACTGATATGATTCTACCACTTGATAAGATGAGAGGAAATATTTATAAAATTACTATTGATGGAATGAATAGAACTAAGATTAATAGTGAGGCAAGTAGGTTATCTGAAGTATTAGATGGGTGGATATATTATAATAATTGGTCCGATAATAAATCTTATAAAATGAAATTAGATGGTAGCAATAAATCAGTTGTGGAATATTAGTATTATTATAATAATTCCGCTAAATAATTGATTATGTTTTATTATAGTGTTGAAATACAGCCTAAAATATATACATGGAATTGTTTATTATAATACTCAATATTCAAACAGTATAAATCACTAAAAATAAATAGTAAATTGTAAAATCGTATTATTCAAGAAATTGAATTTGCGATTTTTTTTATTCTCAAAGAGATTATATTATTGGACAACTGTGTGGACATTGTGCCCCTTGAGGGTATAACCTATGAAAATAGTTATTTTATTTTTGAAAAAATATATGCTGCAATTCATAGTGAATAATTATGGATTAAATAATTGTAAAATTTTTAAAATTTACAATGAAGAATTATTTGAAGAATTATTTTGGGAACATATATATAAAATCTATAAAAAGGGGATAAACAAAATGGAAGGGTTACGAATTTTTAAAGATGAAAGATTTGGAGAAATAAGAGGGTTAAAAATTAATAATAAAGATTATGCAGTTGGAATTGATATAGCAAAAGCTTTGGGATACAAAAACCCAAGAGATGCAATTTTAAGGCATTGCAAGGGTGTCGTGAAACACGACATAGGGGTAGTTACTGGAAAGAGGAGAGATGGAACAGAGGTTATTCAAAATATAGAAATGAGTGTAATTCCTGAAGGGGATATTTACAGGTTAGCAGCCAAATCAGAATTACCTGTGGCAGAGAAATTTGAAGCATGGATTTTTGATGAAGTATTACCTAGCATACGAAAAACAGGGATGTATGCTACAGATGAATTATTAGATAATCCTGACTTACTTATTGCTGCAGCGACTAAGTTAAAAGAAGAGAGAAAAGCAAGGCTAGAGGCTGAAAATAAAGTGAAATTATTAGAACCTAAAGGACAATTTTATGATGATGTCGCAGGATCTAAAGATAGCATTGAAGTGGGACATGTTGCAAAGGTTCTTGCTATAAGAGGAATGGGAAGAAATAATTTATTCTCACTCTTAAGAGAAAAGAAAGTTTTGGATAAAAACAATATTCCTTATCAACAGTTTGTAGATTTAGGCTATTTTAGAGTATTGGAGCAGAAATACACAGTACCTAGTGGTGAAACAAAGATAAACATTAAAACAATGGTATTTCAAAAGGGGATAGAGTTTATAAGGAGAAAAATTGGAGAGTAATAAACCCCATTCTCCTTATTTTAGGATATGCAAATATAAGAGCTTGAATATTTACATATATTTAATATAAAGCACCATGAAATTTATTAATATAAATTATATTTTAAATTTTAAAAGCAGTAGTTAGGAAGCCTTTAACTACTGCTTTTTATATTAAAAGATAAATATGAAAGGTGATAATAATTTTTTCTTATTCATGACAAAAAAATAATATGCATGGGAAAAAATGCAGAATATATTAATTAATATATTCTGGTTAAAAAATCTAAACTTAGTACTGAAAAATTTACATTTAATGTGTGGATTTGGACGTTTAGAGAAAATGCTATTTAATTAATATGAGTATTATGAGAATATGTAATTGTAAATATAAAGAATGGAAGTGAAGTTGATTTATGTCAAAAGTACTTTTTTTAAGTATACCTGCACATGGTCATATAAATCCTACATTAGGATTAATAAATGAATTAGTAAAACAAGGAGAAGAAATTACATATTTCTGCTCAGAAGATTTTAAAGAAAAAATTGAAAAAACAGGTGCCAAATTTAAAAGTTATAGAGTGGAACTGAGCCTTTTTAAAAGAAAACATAAGACTTCTAATGATATGGGGCCAGATAAACTTCTTGATTATATAAATGAAACGCTTAAATCAAGTGATAAAATTATAAAAGATATTTTAAATCAAATTGAAGGCGAAAAATTCGATTATATTATGTATACAGCCATGTTTCCTTTTGGAAGTATCATTGCTCAAATACTGAAAATACCTTCAGTTTCTTCCTTTGCAGTGTTTGCAACTCCTAAAGAATTAAGGTCGCAGCACAAAGAATTAATGAGTGAAAATTTAATAAAAAATCATCCAGTTATAGAGACTTATAAAAAAGTTTCAAGACAATTAAAAGCAGAATTTAATGTGGAAATGTCCCATAATATCTTTGATTTATTTTTTAATAAGGGTGATATAAATATTGCATATACTTCTAAATATTTTGTTGCACATCCAGAATATTATGATGATAGCTTTAAATTTATAGGGCCACCAATATATGATAGAAAAGAAAATTTAGATTTTCCTTTTGAAAAATTAGAAGGAAAGAAAGTTGTTTATATTTCACTAGGTACAGTGTTTAATAATACAGACAGCAATCTCTATGATATATTCTTTAAAACATTTGGTAATACCGATGAAGTTGTTGTAATGGCAGCATACAATGTAGACCTATCTGAATTTGATATACCTAATAACTTTATTGTAAGAAACTATGTTCCTCAATCAGAGGTTTTAAAGCATACTGATGTAGCAATAACTCATGCAGGAATGAACAGTACCAGTGACTTATTGTATAACAATGTGCCTTTTGTAGCAATACCTATAGGTGCGGATCAACCATATATGGCAAAAAGAGCTGAAGAGTTAGGTGCAACTATTTCTCTTGATAAAGATAATATTACTCCAGAGATTTTAAGGGAATCTGTTGAGAAAGTTTTAACTGATCCAAGTTATCTTGAAAATATGAGAAAAATAAGTGATTCTTTTAAAGAATCTGGTGGTTATAAAAAAGCAGTTGAAGAAATTTTTAAATTAAAACGAGATAAGATAGATCAATAAGATTTGTTAATACTAATGCATGAAAAAATAAAAGTTGCAATAAAGGTAGATTAGGTAAAAATACTTAGTCTGCCTTTTACTATGTATGTGGAAAAATCTTTGGAGCAAAGGGTTTCCTTTTTAAGAAGAACTTGTAATACGGAATACTCAAGAAAGCTATGAACGTTCTTATTATTCATGTTTACTATGCAAGCAGAAAGTAGATTGATTATTATCGCAAATTCCAAGTTGTAGTTAAATTATTTCAAATATACCTAATAAAGAAAATATTTAAGAGATTTGTAATGTAGCAGCATGATAAGTGCTGTTACATTTATTTTTTGCAGAAGTAGATAATTATTTTGTACATGAAAAAATTGTATTATAATGATATATATGGATCTATAGATAATAATAAGATTTTATTCTTATAACGTCTATAAAAGGAAGCGAGAGAGCTTCAAAAGATGTGTGTTAAATTAAAATGATAATTAATAAAATCAGTTGTATAAAAAAATGTGATTTGTGAGTAGATAAAATACTTTATTTTGTAAGCTAAAAAACAATTAAAATAAAAGTGGTGAAAATATGAAAATATCTATTGAGGAAATTGGAAGAGAATTTGAAGAAGAAATTATTGTTAAATGTCATGAGGTTAATGATGATATTTTAAAATTAATAAGCAAATTAAAAACAGAAAAAGCTGTGGTTCTTGGTTATGATGGATGTAATATTCACAGGATTCGTATTTCAGATGTGTATTATTTTGAGGCAGTAGACAACAAAGTATTTATCTACTGCAAAGACAAGGTGTTTGAGTCTAAGCAAAAGCTTTATGAATTGGAGGAAATGTGTCAAGGAAAAAAGTTTTTCAGAGCATCCAAGTCGACTATTATAAACATGACAAAAGTATTATCAGTACGACCATCTTTAAGTGGCAGGTTTGAATCAAAGCTGGATAATGGAGAAAAGGTAGTTATCTCTAGACAGTTTGTACCTATATTAAAAGAAAGGTTAGGTTTATAGGAGGAAATAGCATATGGAATTAATGGATTATATAAAAAAGTTAATAAGAAATTATTTTACTATATTTTCACTTATAGTAATATGTGTAACAGTATCAAGTCAGATTTTTTTACCAAATAAATCATTAGAATTAAAAGATATATATATTTATATGATATGCTCATTAATCATTGATTTGCTGAGCCTAATATTATATTCCACAGAAAAATTATCAGAAAAGCAAATGTGGATAAGGAGAATTATTCACTTTATTATACTCAATGGAGTGCTATTAATTTTTACTAATGTGATTGGATTTATGCATGATGCTTTAGATATAATTATATTAGAAATTCAGATAATAGTGATATATGCTATATTTCAATTTTTAGTATGGATGTACGATAAGAAGGACGCTAATGAAATTAATGAAAAATTAAATATAATGAGAGAAGAATTAGAGATTAAGAAGGAAGAAGAATAAAATGTAATTTTCAGCTTACCTCTTCTATTTTACAACTTACATGTCGTTAGTTACAGGATACTGCTTAAGCTATGTACATTTGGCTTAGTAAGTATTATTTTAGTTTTGTAGATGAAGTATGAAATTAAAGTATACTTTTAAGATTAAGGCTGGTTGTAATTAAAAGAATAAATTGAAGAGGTGGAGGAAGAATGGGAATAATAGTAGTTTCTATTGCAGCAGTTATAGAAATTGTTTTTGGAATATACTGCTTTAAGACAAAATCAAATCAGAAGAAAATAAGAAGTTTAATTCACATTAGTGTATTTATAGCATTTGTTGTATTTACATTTCTATCAGTAATACAATGGAGTTTCCGGTGGATGCTTTTGGGTGGGGTATTGCTTATTTTTGCAATTACTTCGGTAATATCACTTATACTAAAAAGGGAAGATAAGAAAAAATACAAAATTAGAAAAATGGTTGGTAAGTCTATCGCAATGTGCATAGTTGTAGTTTTAGCTGTCAGTCCTGAATTAATCTTTCCACAGCATAAGATGCCTGAATTAACAGGAAAGTACAAAGAGATAAAAACGGCAACTTATACATTCAAGGACAATAATCGTATTGATATATATAGCCCCAAAGGTGAAAATAGAGAAGTTACAGTAGAATTTTGGTATCCAGAAGATGATGAAGTCACATCTCATTATCCTCTTGTAGTATTTTCCCATGGTGCATACGGAATGAAAACTAGTAACATGTCTACTTTTAGAGAGCTAGCTAGTAATGGATATGTGGTCTGCTCAATAGATCACCCATATCAATGTTTATTTACCAGAGATGCTGATGGAAAGATAACAACAATAGATAAATCATTCATGGACGAGCTTAATGGTGCAAATAATGGAGCTTATGATGAAGAGACTGAATATAATCTTGGAGTAAAATGGTTAAATGTACGCACCGAAGATATGAATTTTGTACTTGATACAATTATTAAGAACGTAAAGGAAGGTAATACAGAAAAAGTTTATAGTCTTATTGATGCTGGTAAAATTGGATTAATAGGTCATTCATTAGGAGCTTCAGCAAGTGCACAGCTTGGAAGAGAACGCAGTGATGTAAGTGCTGTAGTTAATCTTGATGATGACTTAATAGGAGAATACACTGGTTTTAATAATGGCAAGTTGCAAATTAATCATAATATTTATCCTATACCCATTCTTAGCATTTACAGTGATGATTTAAAGCGAATATATGAAAAAACTGATCCAAGCATTATACCTCAAAAATTAATTTCAGCGACTGCTTTAAAGTCCTTTGAAGTATATTTTGATGGAACAAATCACATGAGTTTTACTGATCTTCCATTAGCATCTCCAATTCTTACAAAATTGTTATGCAATACAGCAAACAGTAAGATTGGTATACAAAAAGCAGACAAGTACTATGTAATAGAGAAGATGAATAATTTAGTATTGCAGTTCTTTAACTGTTATCTTAAGAATGAAGGAGATTTTCGACCAGAAGATAAATATTAAATCGTAGTAGTAAAATCTAATTTTGAATAGCATGGCAATGAAAAAAGCGCTATCATGTGCTATTGATATGGTGAATATTATAAAAAAATATAAGTTGTAATTTAATGAGGTGGAGAGATGAAGGTTTTAGGAATTAATGGTAGTTCAAGAAAAGATGGAAATACAGCATTGATTATGAAGATTGTTTTTGATGAATTAGAAAAAGAAGGAATTGAGACGAAAATAGTTCAATTCTCTGGTAATATAATTGAGCCTTGTAAGGGGTGCTTTGCATGTAAAGGAAAGAATAATTGTGTTTTTAAGAAAGACATATTTTATGAATGTTTTGAAAAAATGAAGTTAGCAGACGGAATTCTTTTGAGTTCTCCAGTCTATTCAGCAGATGTAACAGCAAATATGAAAGCTTTTTTAGAAAGGGCAGGGGTTGTTGTTGCAACAAATCCAGGTCTACTTAAACATAAGGTTGGTGCATCTATATCTGCTGTTCGCAGAGCTGGAGGTATGACAGCAGTAGATACAATGAATCATTTTTTATTAAACAAAGAAGTTGTTATAGCTGGTTCTACATATTGGAATATGGTTTATGGAAAAGATGTAGGCGATATATTTAAAGATGAAGAAGGAATCAATAATATGCATAATTTGGGACAAAATATGGCGTGGCTGCTAAAGAAGATTAATTAATGCTATTAACAGGATCTAAAATGGTATTTCAAAAGGGAATAAAGTTTATAAGAAGAAAAATTAATAATAAATAAAGTTGTCGTAAGCATGAAAATAATTAATATATATTGCAAAAATAATCCTTCATCATAATTCCAAAAATATTACAAGAATTTTAGCTGTAATTGTGAAATGTGAATTGCAACATATATATACTATTTTCATGCTTATATTTATAAATTAAATGGGAATTCGTCATGAGAGGAATTATATTAGGTTTGAAAATTGCGGTGTGTAAAGAGGAAAATCAATAGTGTGTGTAAAATATATATAAGTAAAGGAAAAAGTATCAATCATTTAGGGGAGACGTACTTATGACGAGAGAAAGTAATTTTGAATATGTAAAGGGGACAGATATAGAAGAATGCTACGAAAATTTAAAGAAGGCGGAATTTGTATATCAAAGTTTTCCTGATGCAACAATTATGTGTTTAAGATCAATAGCGGAAACTGTTTTAATAAAAGTCAGGAATGAATTTTACAAAAGTGCAGATAATAGTGGAACTTATTATGGAATAATGGGTGAACTCATAACTGTTTCTGAAGTAAAGTTCTCAAAAGTGTATAGAGAATTTAATATTATAAGACTTAATGGGAATTATGTACTTCATCCTGAGGCTGTAATAGAAGAAGAAACAAAAAGGACGCCCACTGAACTTTTAGAGATTATGCATAACATTCTTATCTGGTATCTTCAAGATATAAAAAATAAAAGTTCTATTGATAGTAGTAAAATCAAGTTTATAAATCCAAATAATTTTAATAATGAAAAAAAAGAATTAACTGAGGTAAAAAAGAAGATTTCAGAAAAGAATAAGAAAATATCTGAATTGAAATTAAAGATAAAGCAGCTTAAGGATTCAGAGAAGGATAAGGCTGATCAGTTATTTAAGTTAAACAAAGAAATAGATAATATAAATGTGGAAAGACTTGAATTAAAAGAAAAAGATGAGTTATTAGAAAAGAAGATTAAAGAGCATGATAAAGAAATAGAGACTATAAAAAAGAAATATAAAATTGATCTCCAAGAAAAAATTGAGAAATTTAAAAAGGAACATAGAGAATCTGAAAAAGCTTCTAATGAGGCTGAATTAGCAGCAGTTAAGAATGAAATTTTAATAAAGAATAATGAAATAGCAGAATTAAAAAGTAAGATAGATGATTTCAAAGAAGAATCTAAGGATAAATTAGAATTACAAAAGGAAATTGAAAAAATAAAAGCTGAAAAAGAAAAACTAGAATCAATGGATTCTATTTTAACTAAAGGGATTAAAGAGTATGATATTGAGGTAAAAAGAATTAAGGAGCAGCACAAAAGGGACTTAGATGACAAAATTAATGAGTTAAAAAGTAAAGAAGATACATATTTAAAAGAAAAAGAAGAATTAAATAATATTAGACAAAAAATACATTCAAAAGAAAATGAAATAAATGAACTAAAAGCAAAAGTAGATGAGTTAAGGCAACAGTCTAAAGAAATAAATTTACTTAAAATAAGTATAGATGATTTGCAAAGTGAAAAAGGTTATTTAGAAAATCGTGATAGAATATTAACTAATACGATTCTTGAAAAGAATAAAGAACTAGAAAATATAAAAGAAGCTTATAAAGCTAATGTTGAAAAGATTGAAATATTACGTAAAGAGCGTAATGAATCAAATGCGTCTCTTAAAAATAAGGAAGAAAAGCTTATTAAGGTTGAAAAAGAGAACTTTGAACTAAAAAAACAACTTAAGGAAATAGAAGAAACAGCTAAAATTGAAGCTATAAAGAGAGATGAAGAGTTAAAGAGAAAAGAAAAAGAGCTGCATGAAGGGATAGAAAAATTAAGACAAGCTTATAAAAATTCTTTTGAATTAACCAGGGAGTATCAAGATGTTCTAGAAAAAAGTGAGTATTCTTATGATAAAGAAGAAGAAAGATTATTAAATATTCAAAAGACAGATGTTAAAGAAAAATTAGTTGAAGAGGATAAGAGCTTTCATAATAATTTAAATGAATATAGTGAGGGCGTGAAAGAAACTAATGAAAGAATAAGAACCTTCAAGAAGGTATTAAAAGAGAAGAGCATTAAGGAAGGTAAACACGTAGCATTTTATAGAGGCTTTTTAGGATTAGAAGCAGAGCAACTTAGAATTTTATATACAATGCTTACTAAGACCAATATTTCCTCAATTTTAATTAGTAAGTCTAAGGAATTACTATCACAATCTAATGAAGATAAGTTCATGGAATTTATACATAAAAAAGCACGAGAATTGAATCATTTATCAGATGAGGAAGTAAGATTAAAAATTTATTATAGATTAATTAAATTAACTGATATTGAATATAAAAACATTTATGAAAGAAGAAGTTTTGTTGAAACTTTAGATGAAATAGTAAATGCAGGATATTCAATATTAGAAGGAAAAAAAGATTTCAAAGGTGGAGGCTCAAAGTTAGAAGCCATAGGTACATATTATTTAGAAAAAGTACTAGAGGATTTTAAAAATAAATATGATAGTGGAGATATAAAAGTACAGCAGGAATTAATTGATAACATTTATAATAATTTTCAAAGGTTAAGTGAAAAAGCTAAAAAAGAAATTTATGACGAGTTACATTTGAAAAGTACTTCTGAAAGTACAGTTAAAGCAGCCATAAGATCAGCCCCCTTTGTATTTTTATCTACTACTATAACTGTTGGGGGATTTTCAGCATTTAGTGCAGTTTCAAGTATAATTTTCGGAATTTCACATTTACTAGGAACAACTTTTTCATATGGGGTATATACTGGGGCTTCATCATTATTAAGCTTTTTCAGCGGGCCTTTTATGGTAATACTTTTTATTGTAAATGGAGGATTTTTGCTTACTCAACATAAAAAACAGCAATTAGAGTTAGTACCTTTATTTATAATGCAAACCATAATTACTAATGTAGCTATAGAAAAAACAAAAATAAACTTTGATAACTATGATACTATGATTGAATTATGGAAAAGAGAAAAAGGGAATTTTGACAAAATTACCATACAAAAAAGATTGCAGGAAAATATCTTAAATAATTATACAAAAGAAAGAGATGAACTTGCTGCTAAATCAGAACAAGTGTCTAGAGCTATTAATACATTATGGGAAGAACATGCAAAATATAATTATAAGTTTAAAGATATTGTGTTAAGCTCTGATAAAAAAGTATATCTAAACTCATATGCGGAGTATAGCAGTACTATAAATAAACTGGAAATGGTTCAAAAAGAAATAGATGAAACTAAAAACAAGGTAGGAACCTTAAAAAGCATATTTAGTTTAGATATGTGGAAAGGGCAATCTTCAAAGCTTGTAAATGAAATGAACATAATAAATATGGAAAAGTCATTAGTTGAAGAAGCAAAACAAAGCCAATACTTTAAGGAAGAAAGTGCTTTATTTTCAGAATTGCAGCAAAAGATAGATGTATTAAATGAAATTCAAAATAAAACTAAAGAAAAGATAAAAGATAAAAGATAAAAATAACCTAATCAGCGTTTTGAAAAATAAAGTTAACTTACTCGAAAATGATTTGGTTAAAATAAATTCAGAATATCCAGATATAAATAACGCTGAATTTAGGGCAATTGGATAGTCAGGATAAGGATAGCAAATTCATTTATTTGGGCTATAATAAATATAGATGTGGAGTAATACAGTCAGAATCTAATTACTTTTGTATGTTTCCAAGACAAGCTCGTGATATGCAGAAATAGAACAACCTTGTAAAAATACACCTTAACTTTTAAGAAGTTTCATAAATTTAAGGACTGCAATAAGATAAAAAATATCAATCTTATTGCAGTCCTTATTTTTAAGCTACTTCATATTTAGTAACTTGTCTTTGAGTAACCTGAGCACCGGATTTCTTAACTAGATCGCCAGCCTTAGTTTTAAAAACATTTTTTGAAATTATAGTGTCCATAAGTGCGTTAACTTCATCTTTTGTAAGAGTAGTTTTAACACCAGAAACACTTAAAGTGCTTTTTTCACCAGCAGAAGTTAAAAAAGTCATAGCTAAAGTATATTCCATTTAATTCACCACCTTTCATTAAGTTTAGAGTTAAGGAAACTACTCCTACTCCTATAGTTTTAGGAGTACTCACAGAGTAAGAGATCATTATCAAATCATAGATGCCTACAGGGAAAGTTCGAAGAGCGAAATATAAAATGCTCATAGAGAAAGTTCTGCTTACCAAATGTAAAATTTGGAGCATCACTTTTCGGTTCTCACTTTTGATATGCCTGCTTAACCGATTTAACTAAGTTCGAGAAGTCCAATCATAGATTTGGACTCTCACTCTTATCTCACTTATCTGCTTAAGCATTTGCTAAACTAGAAGATTCATTAATAAAGTAATCTCTAGTGTTAGCTTCTAATACACCTTTAATTGCATCTGCAATAGCATAGACATTTTCAGGTGTAGCATCTGTTTTGATACCTGAGAAAGTTTTCTTGGTATAAATTGGGTCTCCAGCCTTGTCTAGACCTTTTTGAACCTCAATACTAAGAGAAGCAGAGTCAATAGTTTTTGTTACAGCCATGTTTCATTACCTCCTTTACTTTGTTTTCATAAAGGATATATGGATGAATTTTATTTATTACATAAATAGATGAAAATTATTTGTCAATTTAGCACTATGCTGTTAGATGGATGAGTTCTATTAGTGGCAAGAATCATTTATGCCGTATGAGCCATGAAGTATTGCAAAAAAACACATGATTCTTAGTGAAGAATTAGAGAAGATAGAGGTTAATAATGCTAGTGATAAAGAAAATATTTAAGAGATTTATAATGTGGTAGCATAAACGAATATTGTCATATTTATTTCTTGTATAATTAGATAATTATTCCATGTATGAAAAAATTAGATTATAATGGGTTATATAGTATTATGGATAATGATAAGCCTGTATTCTTACAATGTTTATAATGAGAAGTTCGTGGCATGAATTTAATGATATAAAGAGGTGGAATAATTATGCTATTTGGATTATTTAATAGTAGAAAAGATAACGATGAAATTCATAATATAAAGCAGTATGCAGTAGATATAGCGACTAATTTTAATGACGAAGACAGGGAATATTTGAAGCCAATTTATACAATTAAGTATTATTCTAAATTAAATAATTCAGTTGTTAAAGAAGCAATTTTTTCTAAAAATATAGAAAATGGTGATATTACTTTAGGAGAAGCATTTTTAACGTTAGAGGAAATATTAAAACAGAGTATAGAGAGTAAGTTGTTAATTAATACAATGATTAATAAAAATTATGTGCTTACCAATGAGGAAGAAATTACAATTAATAAACTTGAAGATATAATAAGATTTGGGTTGCTATAATCAATCCAAATTTAAAAAGTGTGAAGCTTAATATAATAGATAATGTGTGTATATTCTAAAATGGATATGGAAAGAGCAATAATTTAACTTATTGCTCAGATATTAATTATGCCAATACCACGAATTTGGGATTCAGGTGGACAAAAACAACTTGTTCTTTGAGAATTGAACAGTATTATATTTTGAAAATATGTTGTTAGGATGAATTAAAATATGAATAAAGGAATGGAATAAGCTGTTATGCATATGAAGGTGAAATAGATGAATAGTTGTAAATTGTTAGAGGTTAAAGCTATAGTTCAAAATCCATATTATAAGGCTCCAAGTTGGATTGATGACAAGATCCAGAGGAGAGAATTTGTTGTTTTAGATGGGGATTCATCAGAAAACGATGTGGAATTATTTTTAATTGAATTATTAGGCTATAATAATATTAACATTGAGCAGGATACAGAATTAGTTATGAAAGAAGTTTTAGAGGAAGTTGAAATAGTAATAGCAGGAGGAATATTATTTGTTGGAGAAAATAGAAATATATTTCCAAGCTGTTGTTGCGGTTTGGAAAGTTGGAATGAAGTATTAGCTGCAGTTATTGATAAATCATCACCATGGTTAGGACACGATCCATATCCCTGCTTTGAGTATGTTGGAAACAACATTCGTATATGGTCTGATGATTTTAAGACAAAACAGTCAAGTGAGATTTACTTTGTTGAGTGTGATAGGGATATTTTAATCGAAAAACTAAAATTAGTTAGAAATGATTTAATTAAATTCTCTAAAGGGCCTTTATATAATCATATCAGTAAACATGCAAGAACATATACTGATTTGATGGTACAGCAATTTGAAAAATGGTTTTCTTTAAACCTTGTGTAATATAATCTGAATGACATGTAGCTAATTGATGAACTGATATAAATCATTATGGGATTTTAATATAAAATGATTTAATTTAATTTGTGGAGGAGGAGAATTTTAAGCTTGACTAAAAGAAATCATAAGTTTGAAATAGCGATATTAACATAGTAGTTATTGTAAATTATTTGCTGAAGGTGATGAGTTGAAGAGTATTATTTTTGAAGGTTGGAAAATAGAAATTGATAAGGAAAAAACTAAAAATTATTATTCACAGTTATATATAGATAGTTTACGTGAATGTTGTTCAGATTGTAGAAATTATTATTATGGAATAAGGCATTTGCCTAAAGTTTTTATAGATTTTTTAGAGAGCTTATTTATTGTTCCAGAAACACCTATATGCGCTTATAAGCTGGATAAAGTTGCTGATAATATATTCCTATATGATGTAAATTATTTAATTAGGGGTAACATATTAGAAAAACCTGATAATGCTGAAACTGTTTCAGAAAATGGAAAGAAGGTATTTAACACAAGTACGTTAACTGATGAGGTAGAGTTTTATTTTACAAAAGAATTACATCCAAGTTTGCGAAATCTTTCTGGTTATGAATCGTATTTTGAACTTCAATTATTTTGTGAAATTCCTTGGGTTATAGATGAGCCGTATGAATAATTGCTGGTTGAAAATTATTGCATCGCACATCTATATAATAAAAAGTTATAAATATTTAAAATAGATGAAAAACTATTAAACAATATAATTGACACTTAACAATATAAGGTATATAATTATACAAAAATAAAAGCTATGAAGAGAAGAGTAATTATGAGGGAATACTCAGAGAGTTTCCATTTGGTGTGAGGAAATTATGAAATCATAATGAAACAAGTCTCGGAGCTGCATACGGATCTTATAAAGTAAAACTTTTCAGGTGGAATTTTATTTTCGCTAAATTTAGTTTAACTTATCTTAGAGAGTGCAACCTATAACTCACATTTGAAGAAGATATGATGTTACGGATGCCTAGCTATAAGATAAAAATTAATTATAAGTGATGCTATGACGTAAGTTCACGTTACAGAACCAGAGTATGATTCAACCTATAATTTTAGGGAGATGGTGTACTTGAAGAGCCTAAAATGGTGACATTTTAGGGAAAAGGGTGGCATCGCGAAATAGAAGTTTCGCCCCTGTAGATATATTTTCTACAGGGGCTTTTTTGACTTTAAAATTAAGCATATAAAAAATTATAAGTTTAAAATATCATGGATATTTTATTTTTCGATTATCTCAAGTATGAAATTTAGAAACTTAAGGAGTGAAAAGTTTATGATAAGTAAAAGAATAGAAAAAAACGAAAGACCAACATTTCCAAAGAAGGCTGTAGTAACAGCTGGAATGCCTTATGGAAATAAGAATCTTCATTTTGGCCATGTTGGAGGAATGTTCATTCATGCAGATATATTTGCAAGATTTTTAAGAGACAGAATAGGGAAAGAAAATGTTATTTTTGTATCTGGTACAGATTGTTATGGTTCACCTATTCTTGAAAGTTATAGAAAGCTAAAGGAAAATGGATACGAAAATACTATGGAGGACTATGTTAAGGCAAATCATTTGAGTCAAAAGAAAACCTTAGAAGATTACAATATCAGCTTAAATATTTTTGGAGCTTCAGCCATTGGAAGGACAGGAGAATTTCATAATGAAGTTTCAGAAGAAATATTTAATACTTTATTTAAAAATGGTTATATAAAAAAGATGTCAGCACTGCAATTTTATGATGAAGATAAGAAAATCTTTCTTAATGGAAGGCAAGTAATAGGAAAATGTCCAATAGCCGGATGTAACTCTGATAAAGCTTATGCAGAGGAATGTTCATTAGGGCATCAATATATGGCATCAGAATTAATTAATCCCATTAGCACTTTATCAGGAAATAAACCAATATTAAAAAGTGTAGATAATTGGTATTTTACATTAGATGAATCCATGGATATAATGAAGGAACTTAATGAGTTTTTAAAGAAGAATACTAATAGACGAAAGTATGAAATTAACACTATAGATGAATTTTTAAAGAAGCCATTAATATATGTTCCAAGAAAATATATAAAGGATGTAAATGAGCTAGAAGCTAAATTTCCAAGCCATGAAACTATAGATGAAGAGAAAAAATCTTCACTAGCGTTTATTTTCCAAACACTAGAGGATAGAGATAAAGCAAAAGAAATATTGGATAATTTAAATATTAACTATACTAGTGGTAAGACATTGGTTCCTTTTAGATTGTCAGGAAATATAGAGTGGGGAGTAAAAGTACCAGATAAAGAAGATTTAAAAAATTTAACATTCTGGGTGTGGCCAGAATCCTTATGGGCTCCAATTTCTTTTACAAAAGCATATTTGGAGTCAATAGATAAGAGTCCTGAAGAGTGGAGTAATTGGTGGGATGCTGATGATTCAATGGTATATCAATTTATAGGGGAAGATAATATATATTTTTATTCAATTGCTGAAATGGCCATGTTTATTGGCTTAAAGGTGGCTAAGGGTGAAAATGTAGATGTTACTAAGCTAAATTTGCCACACATTGTTTCTAATAAGCACATTTTATTTATGGATAAAAAAGCAAGCAGCAGTTCAGATATTAAGCCACCAATGGCAGATGAATTATTAAAGTTTTATACGAAGGATCAATTACGCATGCACTTTATGAGTCTTGGATTATCTTCAAAAAGCGTTGGCTTTAAGCCACAAGTTTACATGAAGGAAGAAGAAAAAGTAGGAGCGGATCCAGTATTAAAAGAAGGAAACCTTTTAACCAATGTATTTAATAGACTCATTCGCTCATGTTTTTATACTCTACAAAGTCTTAATGAAGATATTCCTAAAGAAGAGGTAAGCAAAAAAATTAAAGAATTAACAGAAAAAGCAGTATTAGAATATGAAAGACATATGTATAATCAAGATTTTCATAGAATAGCATATGTTCTCGACGATTATATAAGGGAAGTAAATAAACATTGGGCTAGTAATATTAAAAATGAGGAATTAAAAAGAAACGTAATAGCAGATTGTTTTTACGCTTGCAAAGTTATAGCAGTACTAATACACCCTATAGCACCAGAAGGATGTGAAATGTTTAAAGATTATCTAAATATAGATGATGAACTATGGAATTGGGATAAAGTATTTGAACCTATTACTTCTTATTTTGAAGATGCTGATAACCATAAGTTTAAATTTCTTGAACCCAAAGTAGATTTCTTTAAGAAAATGGAATATCAATATTAATGGAAAAATGATATGGTTTTTACAATTTATGTTGTAATTAATCTAATTCAGATATTGTTTTATTAGAGTGTGTTGGAACAATATCGGATTAGATTAATTATTTGTTAGGGTGGTTTCTAGTGAAATATTGTTGTACTGAGTCAAATAGAAAAGGCACATGTTATCATGAATTTCGAAAAGGAAAATTTACTGGCTCTTTTTGGAATGAAGATTCGCTTTTAATACATGATGATAATTTGTATAGTTTACATCTAGCAGATATATTTCGTAGTGTTGTTCCTTGTATGAAAAAAAGATTATAATGGGTTATATAGTCTTATAGATGACAATAGGATTGTATTCTTATAATGTCTATAATAGGAAGTTGATGTGAGTAGATAAAAGTACAAAGAATACTGATTAAGGTTTAGAATAATTAAGGGTGAACCGTACCACAAGTAACGGAGGTTTTTTTGAAGCATAATTATAATCATACTATATAAGCAAATATAAATATTTAAGAGTGTAGAGCTTCATACTAATTAAAGCCAATATGAAGCTCTATACTCTATAATAAATAGACTAAATCAATAAGAAAATAAATATTTTAAAATATTCCACAAAAAAATTGTAACTGCAATGCAAGCTGAACATTGATAAATTGTTTGATAGAATAAATCATTACGACCTTTTGCTTCTGACCAGTTAACAAATTTCCGTATTAATATAATCACGATAGGTAGAAGCAGTAATTGTAAAAGAAATCAACTGTAACAGAGATTATTTAAATCTTGAAAATGGAATGCTCAAAGGAAACTGTTAAAGTACTAAGAAAAGCAATAGAAAAATAATCAAATAAGAAGATTATGAATTGAGAAATTGAAGATGTGAGAGATATGTATAAGTGACACAGCAGGATAATATATAAAAATAAATGGATGAAATACCAGGAGAAAGAAAAGTACCTGGTATTGTTTGTAATTCTAATATTCCTTGCAAACAACATCTTTAAAGAGCTTATGATTATTAGGAGCATCATGTTCACTGCATGCTTGCTGAAGTTCGGGGATATCAGTAGTTCCAGCTTCTAAAGCAGTTTTGTAGTAATTACATTTATAATTTATTAACTCCAAAGATTTCTGAAGAATTTCAATTCGTTTTTCTGCTTCTGCCTTTCTTTCTAAGAACATTTTATATCGTTTTTCAATACTAGAATCGCCTTCCACGTACCCTTCAAAAAATGTCTTGATATCTTTAATCTGCATTCCTGTATTTTTCAAACATTCAATCATATTGAGCCAGCTTATATCGTTGTCATTGAATCTTCGGATACCACGTTCTGTTCTTTCTAATAAAGGAAGAAGTCCTTCTTTATCATAATAGCGCAGTGTTGGTACTGAAAGGTTCATGATTTTTGCCACTTCACCTATAGTATATTCCATTTGTAGGCTCCTTTCTAATTTTAGGTATTGACCTAAAGTTAACTTTAGGGTGTATTATATGAATAAGCTTAATCTAAATTTATTGAAAAGTCAAGAAATATGGATTAAGAAAATATGAAACATAGCATAACAAATAAAATTTAGAGCCGATTTAAGGAGGGAATAAAACGACCAGTTCAAATGATTAGTTATGGAAATTATAAAAAGTTTAACAGAGAGGAAAGAGTTGTTATGATGAAACATGTAACATTTAAAAATGCTAATATAGAAATGAAGGGGGATTTATACACTCCAGAAAACTTTGATGAAAGCAAGAAATATCCAGCAATTGTGGCTGTTCATCCAGGTGGAGCAGTAAAGGAACAAGTATCAGGTCTTTATTCGAAGAGAATGGCAGAAATGGGATACATTGCACTAGCGTTTGACGCATCACATCAGGGAGAAAGCGGTGGAGAACCTCGCTATCTTGAAAATCCTACAGAAAGAGTAGAAGATATTCGCAGTGCTATAGACTATCTTAGTACACTTTCTTATGTTGATATGGAAAAGGTAGGAGTACTTGGTATCTGTGCAGGTGGTGGATACTCCATTAATGCTGCTTTGACAGAAAAAAGAATTAAGGCAGTTGCTACAATAAGTGCATTTGATATTGGTGCTGGTTTTAGAGGAGATGGTATGCCAGGTGGCTTAGAAGCAACATTAGAAACATTAAATAAGGTTGCAGCTATGCGTAGCGCACAGACCAACGGAGAAGATTCTTTATATATCACATATGTTCCTAATACAGAAGAGGAAGCAAAAGCTAATCCAATGGTGCTTATGAAAGAAGCATATGATTATTATCGTACACCTCGTGCACAACACCCAAATTCAACAAATAAATTACTATTTACTAGTCTTGATAAGATTATAGCATTTTCAGCATTCGGATTTGTGCCAACATTATTAACACAGCCTATTTTAGCAATAGTAGGAAGTGAAGCTAATACAAAAGGATTTAGCGAAAATGCAATTGAATTGGCAAATAGTCCAAAAGAATTATTTGAAGTAAAAGGTGCGACACATATCGCAATGTATGATGTACCTGAGTATGTTAATCAAGCAGTTAATAAACTTGGAGAGTTTTTTGGGGAAAATCTATAATTAAGGACAGCTTTAAAAAGGAAGTACTTATAATATTTAATACATTGGCTATTATAAAGTTATCAGATGATAGAAAGTGTCAGTTCTGAAATATTTCTAAATTTAAAAGATTATGTGATTGGACAACAAGCCTTAATTACCGGTGAAACAGTGATTAAGGCTTTTTCTAGTGTAAAAAATATGGAAGATTACTATGCTGAGAAAAAATGCTTTAAGACACTAAAATATCGGAAATATCAGCAATACATTAGAAGGCAGTATTGTTTAAAATTAATGATTAGTTTGCATTTCTTTTATTATTTCTAAAAACTCAATCACATCCTTGGATGGATTTAAGGGATAGAACAAGCCATAAGGTATAGTGAAATCCAAATCGCTAGGGATGGTCACTAATGAGGGATGAATATCTGACCAGGCATCTAATGTTAAGAGGATAAGGTTATTTTGCCCGCAGCGATTGAATACATCAATATCATAAAGACGAGGAACACTTTTAATATGAATTTCAGGATGGTTCTTTATGAAAAATTCACTGATTTCATCAATGGATGCACTAGTTCCACCTTTTATTACAACCAACTTTTCTCCATACAAATCTGTTACAGAAAGTTTTTTCTTAGAAGCCAGCCGATGTTTGCGAGATACAGCAAAGCAAAAATGGTAAGTTCCTAGCTTAAGTTTATGGGAATAATCATTCCAATTTTCTGTGAGGAATGGTCCTACTATGAAATCAAAATGTTTGCCAATGTTACGATAAGTGTTTGGTAATGTATATGCATCATCCTCAAAAGGGACAATTTTTATCTCGAACTGGGGATGTTTATTACTGATTTCATTCCAAAGATCCAGTAAAACCTTACAGGGATTAAGTATAGAGGTCCCAACCCGAATAATATGCTTATCTACATGCGTTGTATTACGTGTACGCAGTAGTGCTTCTTGAAAATACTGCAAAATAAATTCTGCATCCTTATTGAAGGATTTTCCTGCATCGGTCAGTTCAACACCATGGTTGGTGCGAATGAAAAGAGGTACACCCACTTCCTTCTCAAGGGAATTAATCTGTTTCATCACAGCCGTTGGGGAAACAAACAGTTTTTCAGCAGCCTTGGAAAAGCTACCAGACTCTGCTACCTGAATAAAAGCATTCAATTGTTCATTCATTTAAAGAATCTCCTTTTTGCATAAACTTTTAGTTAATGCCATGCTAACCTATTTGAACTTCCAAATCAAGCGATTATACATTAATATTAGAACTATACTAAAGAAACACAAGTTAAAAAAAGGAGATGCTTACTATGAAAACAGCATTAGTTACTGGTTCCAACAAAGGAATAGGTTTTGAAATTTCTAAAAAATTGTTAAAAGAAGGATATCACGTTTTAGTTGGTGCTCGAGATGAAAGCCGTGGCAAGAATGCAATAACAAAACTCGCTAAGTATGGTCCTGTTGATTTAATAAAAATAGATTATTCAGATAGTGAAAGTATAAAAGAGGCAGTACAGCGAGTTTCAAATGAATATAAAAAGCTTAATTTATTGGTTAATAATGCAGGCATACCTGGACCACTTATTAAACGCCCTAGCTGGGAATTTACAAAAGAAGAGCTTTTAGAAACTTATACAGTAGATTTTCTTGGTCCATTTGAGCTGTCGAAAGGATTATTACCCATTCTTATAGAGAACCATGGCAAAATAGTCAATGTTTCAATTCCAATTGAACCAATGCCATTTCCTAATATGAACCCTTTTGCATATCTAACTGGAAAAGCACCACTTAATATAATGACAAAGTCTTGGGGAATTAGCATTGATGAGATTGCTCTTCCGGTACAGATATTTGCAGTGATGCCCGGTGCCGTTTCAACTGATTTGAATAATCATACAACAGGAAAGGGTGTAAAAATGCCTGAAGAAGCTGCAGAATGGATTGCAGGTTTAGCTTTGGATGAAAAAAATCACAATGGTCAAGTTATCAATTTTGAAGGTAAGCTAGCTGACTATAAAAATTTAGTATAGTTTATTTTGTCAATAAAAAAGACACTGGCAAATGGACTTGTTATTTGATTGTGCCTAAATATAATAAGAGAGTAAGGAAAATGGAGTATCACTTATTAATGGATACGGTGAATCATAATTCCTTCTCTTATTTTCTCTTCATTAATATTTGTATAGTTCAAGCGTAAGGTATTTTTATGACCGCCATTTGGGAAAAATGCTTCGCCTGAAATAAAAGCTATACCATTTTTTTAATGCACATTTTAATAATTCAAAGTGGTACTCCGTCTAGACATCAGATAAATAAATGAATTAGAAGTTTAAAATCGGGAACTGATAATGCACAATATATTAGGAGAGATGCCATAACAATATTGAATAACTTTCTATGATGGCTAAGAATTTTTTGAAATAATGCACCAAAAAGAGTCCAGCAGGACATTGATATAAATCCTACGAATGCAAGGAATATAGCAAATAAGTATAATATTATGCTCGATTTATAATAGGGGATTATAAAAATTGAAGTTGCCGTTATACCATAAAGTATTGTTTTGGGATTCATGAATTGCATAAGAATTCCAGATTTAAATGTGTAGATGCTGTAATCATTAATTGCATTTGGGTTAGAATTACTTTTGAGTATCTTGATAGCTAAATATATTATGTATGCTGAACTAAATACCTCCATAGACAACTTTATGTTAGGAAGAAGTTTAAATAAAAATAAGTTAAGATAACCACACAATAACATGATCACAGCCATACCAGTTGTAGCACCTAGAACAAATTTGAATGTTTTTTTATATCCAAAGTTAGTACCATTTGTCATAGACATAATATTATTTGGACCAGGTGTAAAAGTTGAAACAAGAACATAAGATAAAAGTGCAGATAAATTGAACATAGCTGACCTCCTTAATGATTTAATTTGAAAAGATAGTAGTAATATGATATCATGCTACTAACAATTAGTGAAATCAATAGTTTAAATTGTAACAATCAAAATAAATGATTGATTTGGAGGCATATACAAATGGAATTTCGTCAATTAAATGCATTTATTACCGTAGCTAAGCTGAGTAATTTTACAAAAGCAGCATTTGAACTAGGATATTCACAATCTGCTATCACTGCTCAGATACAACAGTTGGAAAAAGAATTAGGTGTTAATTTGTTTGAAAGATTAGGGAAAAATATATCTTTGACTTCAGAAGGAGAACAGTTTCTTGTTTATGCTAAACAAATAATTAAGCTTTGTGATGAAGCAAAAAGTAATTTAAGTACATCAGATGTAGTAAAGGGAACTTTGACAATAGGGGCTAATGAATCACTTTGCGCTGTTAGGCTTCCTCCTCTATTAAAAGAATTTCATGACCGCTATCCGGAAATTGAAATCCTTTTAAAAATGGAAGGTAATAATAAATGTAAAACATTGATAAGAGAAAATCAGATTGATGTTGCCTTTATTATTGGTCAGAAAATAAATGATTCTGATTTAATCACAGAATTGGAATTTCCTGAACCTTTAGTTTTATTAGCAATTCCAGGACATCCACTTGCTTTCAAGAAACATGTTTATCCTGAAGATATTGCTGACTATAACATAATTGTTGCAGAAAAAGGCTGCGGATACCGAAATCTTTTTGAACGAAGTCTCAATGATGCTGGGGTAACTCCGAAATCAATAATGGAAATGGGAAGTATCCAATCAATCAAACAATTGACAATGAGCGGGCTTGGAATAACCCTGCTTCCCAAGATTGCTGCTCAGGAGGAGTTGAAACGAAAGCAATTAAGAGAACTTCAGTGGTGGCAAGATTCCTTTTATTTGACTACGCAAATGGTATATCATAGAGATAAGTGGGGTTCAAGGGCATTAAGAGCTTTTATAAATTTGAGTAAAGAAATGATGAATAGTTAATATAATATTTTGAATTCAAATAACAAAGGTATGTATTTTGTGTTCTTAGTGTTTTCTTATTTAATTAAACATTAACATTTTTATATGACGTAACAGTTAAAAATGGAATGATAAGAAGCATCTAAATAAGAATTCTTTATTTTTCAACGAAAGAACTTTTTATATAGATGATAAAGGAAAAAGAGTTATCACTTGCTATTGATACGGTGAACCATGTCATAAGTGAGTGATAAATTTATTAAGGCCAAATAATGAAAATGAATTAGAATAAAGGAACTTACCATATAAGAAAGTAATATGGTAAGTTTTATTTAATTTATAGACAATATAGAGACAAACAGAATAGAAAATTCATTGCAAAGAGCCTATAAAAAATGAAAAGAACACTATTTGATATAATGTTCTTTTCATCTTTTTAAAGTACCCATACCTGTAGAAACAAACCCAATAATCTCAGAAATTAGAACTTCTTGAGGGAGTGGTCTATTCTGAACTTCCCATTTGTAAGTTACATTATAAATGGAAGTGCTCATCATTGTTGCAACTAATTGGGCTCGTATTTGTTCATTTTCAGCTAATTCATGGTCTTTTATTAGCATCTCATAGATTATGGAATATAGCTCACAAGATATTTTATCTCCTATTAAAGGTAAAATAGAGGCAAAACCGCACTTGCAGATGCTTTTTACCATTTCAAAGTACTCACAAACGCAAAGAATGAGGCTACGTATAGTATTCTCATTTAGGCGCATCTCGCCTAGTAGTTTATGGGAAAAGATCTCAGAGAATTTCTCTACTATGACGGTGTCCAGTAGTGCATATTTATCTGTAAAATGTGCATAGAAGGTTGCACGGTTTATGGTGGCTGCGGTAGTAATATCCTTAACTGTAATGGAGTCAAAGCCTTTTTTAGTAACTAGTGAAATAAAAGCGTTGATAATAAGATCATGGGTTCTTTTTACTCTAGGATTATTTATATTTACTGACATATCATTACCTCATTTAAAAGAATTTTAGTTAAACTCATATTGCAGATTTAGTTTTATGTAAGCAACACTTTATCAATTTTGTTGGTTGAAAAATGTATAAGCTAATTTTATAATCATTATAAGCAACACGAGTTGGCTTTGCAATATGTGTAGCTATAATAATTGTTTGAAATAAATATTTATTTCTAGGGGGTTAAATATGTCAACTATAAATCCAAACTGTAAATGCATAAATAAAAGCTGTAAAAATCACGGGAATTGTAAAGCATGTCGAGAGTTTCATAAATCACAATCATATCTTAATGAAACATATTGTCAGGCTGGTGCAGTTAAATTCATAACTAAAGGATTAATATCTAAGTTAAAGTTACATTCTTAGCACGCAACCTAGCAATTCAAATGCGGACTTACTATAAAATAAAAAGGGTGGGAGTGCTGAAATATGAATTTAGATAATCCGATTTTCAAGAAGCCAATTACAGAAGTTATTAAAGCAAGAACATCTATGAGGTCATATAATGGGGTGCCTTTGGACAAAACAATAGGCGATAGCATAATGGATGTCATAAATCAGGTTAAAGCACCTTTTTGCACAAATATACGAGTTAAGATGATAAACTCTAAAGATTCAGATTTAAAGCTTGGAACCTATGGTATTATAAAAGGAACTTCTACCTTTATAGTCTCATCAATTTCAAAATCAGATAATGCATTAGTTGATTTAGGATATTTATTGGAAAGAGCAGTGCTGTATGCAACTGATTTAAATTTGGGTACATGTTGGCTAGGCGGTACCTTTAATAAAGGTCAATTTGCAGAGGTTATGGAGCTTAAAGATAATGAAATCCTTCCAATAGTTATACCTGTAGGGTATCCTAGTGAAGCAAGAAGAGGTATGGATACTTTCGTTAGGTTTATGGCAGGTTCTAAAAATAGAAAAGCCTGGTCTAAACTATTCTTTGATGTAGATTTCAATACACCTTTAAAGGAGCTGGAAAGCTTAGAGTATTTTATTCCCCTTCAAATGGTAAGGCTTGCGCCTTCAGCAGCAAACAAGCAACCTTGGAGAATAATTAAAAGTTCTAATTCATACGATTTCTATTTAGAACGAAGTAAAGACTCAAAAAGTGATAGTTATAATGATATGCACAAGATAGATATTGGCATAGCTATGTGTCATTTTGAGTTAACTTCAGCAGAATTAGGGTTAGAGGGACATAGGGAGAAACTTAAGCTTTCATCTCAAGATAATAAAAAATATATTATTTCTTGGGTTAGAAAATAGGGAAGCGAATTTGCTATAAATGAAATATATGTTGAATATGTAAGAGATATTGATTACTATAGCAAGTTATTTTCACATTTTTCTTCATGAACTTTTTTTCTTTCTTCGTTAATAATTTGCGCCGCGTTAGGAGATGTATACTTCACTATTTTGGTATGAATAAGGTCTAAATTTTCATTGAGATCATTTTAAAGGAGTTTTCTTTTTGACACAGAAACTAATTCCGCTTATTGCTGACAAAGGTGGGATTGTGAACACTTCAACAGGATTAACTCGTTTTACATCTCCAGGTTCCAGACTTTATGCTGCTGCGAAAGGTTCAGTAGAAGTCTTCACTAGATATTTAGCAAAAGAATTAGGAACTAGAGGTATAAGAGCGAATACGATAGCGCCTGGAGCTAGTAAAGGTGCCCCTTATTTTAGAAATCGCTTCATTGATTTAGTTACTTATAAATTAGAGGATGAAGTAAATGTTACAGAAGGAGTAAATTCAGGATTAAGGAAAGATGCTGGCAAGCAATTTCTTGGGCAAGCTATAGTAGGATTGATAGAATGGTGGTTTATAAATGGAATGCCTTTTTCTCCTGATGTCTTGGTGGAACATTTAGGAGAAGTGATAGAGAGAAATTTGTAATCATTAATTTAGACTGATTCAAATCCATTTAATTATAGATAGGAAATATTAAAGGAGGTTTAGAATAATTAATAGTGAACCATATCACAAATAAAGGATAATGAGTAAGTTTGGGTAAAATTAGGGATAAGAAATAAATTTAATCCTAGTAAAGCTTATTGTTGCATTACTAGGATATTTTAATACGTTCAATATTATAAAAATAGGTGCCAAAATTTTGACTCTTACGTTTAAATTGAAAAATTGTAATTGCTAGACTAAAGTATATTAAGGTTAAAAAAATATAATTAGTGAGGTGAAATCAAATGTATATTATACTGATTGCAGGAATGCCAGCAGTTGGTAAGACAACATTTGCTAACAAGGCATAGAGGTCACAGAATATCCTGAATCAATAAATCACAATGCTATTCCTGATCAAATAAAATGGGTTTCAGTGCAAATCACAAGCACTGAAACCCATTTTAATTTGAAGCTTAACGTATATATTAAAATATCATTACTAATATTTTAGGTAACAGCATGGAAACACCTACTGCATAAAGTAAATCAAGCCACATTACAGAACCAACCGCGCCAATATAAATAAGACCAATGACAGGCGCTACTAATATTTTTATTAAAAATGATACTTCTTTATTCTTTAAAATAGCATTTACAATACATTTTGCATCACCTGTACTTGGGAAGGCATGCATTAAAATAGAAAATCCAATCCAACAAATTAATAGATTAATTAAGTTTGAATATTGTCCAAATTCTACTATTTCAATTGATACTGGTAATGTAATTAGAGCTCCTATGATAGTATTTATTAAAAATGGACCTACTGAAATAAAAAATACTTTTAATGGATTATCACTAGGTTCGTGCAAAACATATCCACAAGGATTTGATAATTGGAAATATTTAACTTCATAGACTGGCACTCTCATTAGTCTGCAAAATATCTGATGTGCTAGTTCATGAACAATTACTCCAGGAAAGGTTACAATAGAAATTAAAAAACCAGGTATTATCATTAATTTTGCCCTCCATTACTTAGGTAATAATCATTTATATTTATTTTTCCATTAAAATAATCTAATGTAGTATTATCAAATTTGTTTCCTGTAGAAAGATATTCATCTTTGATTTTATTAACTTCTTCAGTT
+>6_2#NODE_17_length_39819_cov_63.5061_ID_33
+TTCAGCTTTCTTCGTTTCATTCCATTCCAATAAAATTTTATGATTTTCTTCAGGAAGAGTAATGTTTATTTTTCCAATCGGCTCGTCTTTATGATAATTATTTATCACTAATTCTAATAGATTCATAAATCTTTCTTTATGCAATGCTAGTTCCGCGCCGTTATATACTTCCGGATTCGCATCAAAATGAATCATTAACTCATTTTCATCGAAGCGCTTATATACATTAATCGATAAGTCATCGACAGGTCCTGCTGATAAATTATGTGTAATACCACGATTTCCAGCAAAGTTAAGCCCGTAATCAAAAGGCATAACATTCACTAACGGCCCAAACAACCTTTGATTTTCACCTAGTAACTTTAAGTCTCTTCTTAATTCCTCATGACGATATTTATGATGACGACGTACGTCTCGAATTTCTTTAGAAACTTGCTGTATTAATTCTACAAAAGTTATATTTGGAGTTAACTTTAGACGAAGTGGAACTAAATTCATTACCATGCTAGGTGTATGAATAGATACAGAACCAAGACGCCCCATCATCGGTAAACCTAAAACAATATCATTTGCACCTGTTAATTTATGCATATAAATACTTGTTACAGCTACAACAAATTCGGGCCAACTCGTTAACGAAATATTAATATCTTCTAGTAAAGTTTTCGTACTAGCATTTGATAAATAAGCAGTTTCTCGTAAAAATCCATTTGATGTTCTCGGCGCTTGTTCTGCTAAACTTATAACTTCCGGTTCATCTGCAAACTTTTCTAGCCAAAAAGTACGATTTTCCTGAAATTGTTTAGATTCACGATACTCATTATCTTCTTGTACAATTTTGGCAAGAGAACCAAATGGCTTTTCATTCTTATTTGTTTCTTCTATAAGTGATGTATACTCATTCGCTACCTTTTGGCTAAGAAGTGAAAATCCATAGCCATCCATCACAATGTGATGGATGCGCTGATACCAAAAGAAACGATTATTTTCAACTTGAATAAGTGCTTCAGTAAATAATTTATCTTCTTTTAAATCTATCGGTACAGATAAATCATTTTTCATCCATACTTTAGCAGCTTCTTCAGGATTTCCCTCTTTACGAACGTCAATAAAATGCATATGAAACGTTGACGATTCCTCAATAACTTGCCATGGGCCAATTTCATCCTCTTCGAAACGAACATGAAGTGCTTCTGCTTCTTTTACCACTTTACGTACAGCTAACTCGAAAATTTCATGATTAATATTTCCGTTTATTTCTATATATTCCCCAGTATTATAAATCGGATTAAGCGGATCTAATTGTTGCGCAAACCACATACCAGACTGCGCAGATGATAACGAATGGCGAATCTTTTGACTATTAGGCATTCTTTACTACCCCTTTATTATGTAGTCTATTTGTTACAGCACTTGTGCTGCTTGTGAAGATAGTAAACGGTACCAATCATCAACAGTTGGACGTTCTGCTAAATCTGCAAAAGTGATTTCTTTCCCTTCGCGGCGCCACTTCTCTACTAAACTCATAATTCTGACCGAATCAAGTCCTCTATTTAATAAGTCTTCATCAACTTCAATACTCTCTACTGGCTCACGGAGTAGTTGTGCAACTAGTTCATGTACTTTCTGTAAAGTGATTCCTTCACTCTCATCGCTTTTTACACTTTGTAAATCTTTTAATAGTAAGTTTGTTGATGTCGTTACTGCACATCTATTAGATGCATACTGCAATGCTTGTTTATGATGCTCTAGCGAAAAATCAGCAACTGCATCTGCTACAAAAAATGGCTCTATACCATCCATAAATGCTTCACAAGCTGTTAAAAGGCAGCCAATATGCGCATAAATACCGCAAATAATAAGTTGATCTCTTCCCTGCTCATTTAAAATTTCTAATAGATTCGTCTTTTTAAATGCACTATATCTCCATTTGGTTAGGAATATATCATCCTCATCTGGAGTAAGCTCATCGACAATTTTCTTTTTATCTGGTCCAGCAGGAATACCGTCACCCCAAAAGTCTTGTAATAACCCTCGTTGTTCTAACGTTTGTCCACCAGGTTGTGCTGTATAAACAACTGGTATACCAAGTTCCTTGCATCTTTCTCTTATCACCTTAATATTTGAAATTAGTTCTACTTTTGGCGATTCTTTATCGCTATATGCATCAAGAAAATATTCTTGCATGTCATGGATTAGAAGAACCGCACGTTTCGGATCTGGCGTCCAATTCACTTTATTTTTTGGTAGTTCTGATTCAATTGGCATTTTATATACTGAAATAGATGGGATAGCCATCTAATCACTTCCTTCCGATTTTTATTATTGTTTTACTGTAATAAGTTTTTCAGCAATGACTTTACGTAATTCTTTTTTGCTTACTTTTCCAACACCTGTTTGTGGGAATGATTCAATAAATTCAATTCGATCTGGAATCTTATAAGCTGCTATACCACGTTCTCTTAAGAACATTTTTAATTCGTTTGCAGTTAGGACTTGTCCACGAGCGATAACAAAAGCGCAAGTGCGTTCTCCTAAATAATCGTCAGGCATAGATACAATTGCTACATCATGTACTGCATCATGTGCTAATAGATGATTTTCAACCTCTTCCGCAGCAACCTTCTCACCGCCACGATTAATTTGATCTTTATCTCTTCCTTCTACAATGATGTAACCTTGTTCATTTACTTTCACAAGATCTCCTGTACGATAAAATCCATCCTTTGTAAATGATCGTGCATTATGCTCTTCCGCTTTATAATAACCACGAATTGTATATGGCCCTCTTGTTAATAAACTTCCTACTTCACCGGGTTTTACATCGTTATCATTTTCATCAACAACCCTTACTTCATCGAATGTAGACATCGGTCTACCTTGCGTATGAATAATGATTTCTTCAGGATCATTTAATCTTGTGTAATTTACTAACCCTTCTGCCATACCGAACACTTGCTGTAACGTACATCCAAATGTAGGGCGAATACGCTTCGCAACTTCGGCACTAAATTTCGCACCTCCTACTTGAATAACTTGCAGGCTCGATAAATCGTCGTTACGGGAAGATGCTGCATCAAGCCAAATCATTGCTAATGGTGGAACGAGCGCTGTAATCGTAACTTTTTCTTTTTCTATAAGAGCAAATGCCTCATCTGGACTACCTCCAGTTGCCAATACTACTTTTCCACCCGCATAAAAAGTTCCAAATGTCCCTGGAGAACTCATCGGGTAATTGTGTGCTACTGGAAGAACTGCCATATAGACACTTTCTGCATTTAAATTACAAATGTCAGCGCTAACACGTAAACTATAAATATAGTCATCATGTGTTCTAGGAATTAATTTAGAAAGTCCTGTCGTCCCTCCTGATAATTGGAGAAACGCAACATCACTTGGCTGAACTTCTGGTAACGGAATCGGATCCATATAAAGATCAGTTATGTTCACGAATTCTTCTTCTTCCCCCACTACGATTACATGTTGTAAAGCGGGAACTTTCTCTTTCACTTCTCTTGCTAGTTTTCGGTAATCAAAGCCGAGAGCCTTATCTGAAATAATGTAAGCACTCGCCTCACCGAACTCGCAAAAATAACTAATTTCACTACTGCGATGAGAAGGTAGTGCAAAAACAGGAAGTGCTCCAATGCGAAATAGCGCAAAGCATATTTCGAAAAACTCTATAATATTAGGTAACTGGATTACAACTCGGTCCTCTTTCTTTATTCCTAAATTCAGTAAACCTGAAGCTAAGCGATCTACCTTTTTATCAAGTTCACTATACGTTATATGCGTATTACTACTTACAACCGCAATTTGATCCCCATATTTTTCAGCACGTTCTTTTAACATCGAACCAAATGTTTCTCCAAGCCAACACCCTTCTTCTCGATAGCGATTGGCAAATTCTTTTGGCCATTCCGTATAACCTATTAACATTCTTTCTTCCCCCTATTTTTCATTCAGCAAATTATCTCTTAACCCTAAAGCCTTCAACATTGTTTGGAACTTAGCTGATGTTTCTGCTAACTCATCTTCTGGCTTTGATTCAGCAACAACTCCAGCACCTGCATATAAGCGAAGTGTATTCTCTTGCACTTCAGCACAACGAATTGTAACAATCCATTCGCCATCTCCATCTAAATCGCTCCACCCTAACATTCCTGTAAAGAATTCACGGTCAAATGGCTCAATTTTTTGAATAGCCTCTCTCGCTTCTTCCATTGGAGTTCCGCAAACTGCTGGCGTAGGATGAAGAGCAATTGCTAATTCTAAAGAAGACGTATTTGGGTCCTTTAGTTCACCTTTCACTTCCGTAGACAAATGCCACATTGCTTCACTATGAATAACTGAGGGTTTTTCTGGAACATGTAATATATGACAGTAAGGGCGAAGCGCAGCGGCAACCGCTTCAACTACTACCGCATGTTCATGTAAATCTTTTGGAGAAGAAAGTAATTCTTCTGCCCTTCTTTTATCTTCTACTGGATCCTCACTTCGTGGTCTTGAGCCAGCCAACGGATTAGAAATTACTTGCATACCATGACGTGAAACAAGTAATTCAGGACTTGCTCCAATTAACGTCTTACTGTACTCGTTTTCATCTTTCGGCAAATTAACAGCAAATGTGTAGCCGTGCTTATTATGTTCCGCTAATTCACGAAGTAGTTTTTGTTGATCAATTTTCTCGGAAGACTTAACATCCAATGATCTAGATAGAACGATTTTCCTTAAATCTCCGTCCTGAATTTTTGCTATTCCTTGCTTCACACCATCCATATAAACTTCAGGAGCTGGAACCGGTGTCATTTCAAATGTCAGTTTCTCATTTCGTTTTATCTCATTTGTCGTCTCTAACTGTAAACGCTCAGTAATTCTACTATGTTCTGGTACGATAAGTTGAACTTCTTTTCTACGATCAAAGGGCAAAGCACCAACAGCGATAGGATTCGGATTTCCGGCTTGTTTTGCATTACTTAATACCGCTTGTACAAGTTCTGGAAAGCTTTCAATTTCACGATGTTTTACTGTAGTAAACTCTCCTTCTGCTAATATTGTTCGAGTTGGTGAAGCGAAAAAGAATGAAGATTCTGTCTTATAATCTTCTAAAAGTTTTTCTGACAGTTCCTTTACGGCTGTAAGTTCATTCATAGTATAATAACCTCCTGAATTTTTTATTAAACTCCTAATGTAGCTCCGCCATCGACACATAAATTGTGCATTGTAATATGACTCGCTTTATCAGAAGCTAAAAACAATACTGCTTCAGCAATTTCTGAAGGTTGTGCAATTTTTTGTAACGGAATACCGAGTCTATATGTATTTTGAGAACCAGCAATTATATTTTCAGCTCCATTCTCATCAGCCCATAGTAATCTTTGCATTTCAGTTTCAGTAGAACCAGGAGAAACTAAGTTGCAGCGAATATTGTATGCTGCAAGCTCTAACCCTAAACACTTCATAAACATTGTCGTTGCGGCTTTTGATGCAGCGTACGCAGCCATTTCCATTCTCGGAGTATTTGCCGCATTTGAACCAACTGTAACAATTGCCCCTGACTTTCTTTGCATCATATGTTTACTTACTGCTCGAGACATATAGAAAACTCCTGTAGAATTTACAGAGAAGGTTTTATTCCAATCTTCATCACTTAAAGAGTGAATTGGTCCCATACGTAATATCCCTGCAACATTTATTAATATATCTATTGGTGCTATATCATTTTCAATACCGTTTACCATATCTTCAACAGCGGTACTATCACTCACATCTAAATGAAATATTTTCATACGTGTTTCATTTAATTCATTTTCATTTAAGAGTACGTTTAACCCCTCTTCATTTTGATCAACCGCAATAACTGTAGCTCCTCTTTCTAAAAACATTTTGGCAACAACACTGCCTATACCTTGAGCTGCACCTGTTACTAAAACCGTTTTTCCATCAAATTCCCCTAAGTTCATTTCCTCTATCCTTTCATTTGAAAATTAATCTAATTAAACAAATAGCAATAATGATAACGATTATCACTATCAATGTAAAAAATAATACACTTACTAAACTAATTGGTCAAGTGTACTTTTCATCAAAATATTATTCATTGATAATGTTTTTCATTTAATATTCTTACATCGAAATGATAATCTTTCTCAACAAACTTGTCAACCTATTTTTATTTTTCAGATAAAATATTTTAGTACTTCTCAATACAATTACATCTAAAAGCATTAATAAGTACTTACATTAAAAAATTTAATTCGTACTCCTCTTTTTAAAATTGAAGAAGATAAACTTTAGATACCTTCATTTACAAAGCCTTACCAAAAACTCAAGTATATATTTTCTCAACATTTTTCTGAAAATATCAAGAAAGTATATCTTGCAATTACCGATGCATGTCGTGTTTATAATTTAAGATTTAATAAGTATTTCGAATATAATATATCAATTTATGATATTCCAATATAATCCAAACGGATACTTTACTCATTTTTTTGCCTCTAGAAAATTCCACATGTTGTAATTCATAAAAAAGCACCCTATTAAATAGGGTGCTTTTTAGTAAACATAGTGTTAAAGAAGATTTATATACTTACGCTACACTGCGATACTCTTCTTCTTTTTCTTTTTTCTGCTTAGGCACTTGGATTAAAAGTGCGATAATAAATGATACGACACATAATACGCCGATCACCATGAAAGTTGGTTTGAATCCACCTAGAACTGCACCGATAAAGGAACCAGCGAGCGCTCCAAATCCAAATCCTTGATACACAATTCCGTAGTTCTTACTATGGTTTTTCATACCGTAGAAATCACCAACGATAGCTGGGAAAATAGTGATATTTCCACCAAAGCAAAACGCTACACTTGCTACACATACGAAGTAGATACCATAATTTAAATCTACGAAACTTAAAACCAAGACTGACGCTGCCATAACAACAAATGTACCAGTAACGATTTTTAAACGGCCGATTTTATCTGATAACGGTCCTAAAATAATACGACCTAATGTATTGAAGATTGCAACCATAGCCACCGCATTAGCTGCTGTCGCTGCGCTAAGCCCTACAAGTTGAACACCAATGTCTTTTACCATACCAATTAAGTATAAGCCACTCATACATGATGTAAATAACATAATAAATAATAAGTATACTTGTTTTGTGCCCAACATTTCTTTCGTTGTATATTCCTGAGTTTTTGTTTCATGAACTGCTCCTTGATCTGCAGCTTGATGGATTAAACAAGCGCCAAGGACAATCATAGCTGTAACAATTAAACCCCAGTATATAAACGCTTGTGATACACCAACTGATTCAATTAACTGTGCGTTAATATATTTAAAAATTAAGCTACCTGAACCATATGCAGAGACAGAAATACCAGCAATTAAACCTTTACGCTTTGGAAACCACTTTATTAAATTGGATAATGAAGTGATATATGCTGTACCATCTGCATAACCTACAACAACCCCTGCTAGTACATAAAGCAATATTAATGAGGAAGCTTGTGAACTAAGTATTAATCCAATTCCTAATGCTAGTCCAGCTATCATAATAAGTTTACGAAGTCCCCATTTTTCTTGCAATTTACTCGCAAACAAAGTTGAAAACGCTAAAGACAGGCTAGTAATTGAGAAAGTTATAGCAACAGCGTTAAGACTCCAACCGTATTTACTCACTAAGGGCTGATTGAATAAACTCCATGTATATATCGTACCAAGCCCCATTTGTACTATGACTGTTCCAAGGACAACAAGCCATGGATTAACCGATGATTTTTTCATACCATCTCTCCTCCTCTTTCTATTTCAATGCTATTCGCTAAATATGCTTTTTTTATTTTTATTTTCGCCACCTCATTCGACTTAACAACTTCATTGTATAGGATGTTTTCGCTTATGTAAGCACTTACAAGATGGAGCGTCAAAAATATGGAATCAGTTACAGAAAACGAAGGGTGAAATACAAAAAACTACTTGTTAAATACGTAGTAGTTTTTATAATGTTTTACATCAATACGACTTATGTGTGTTTTCATATCCTCTTTTATACAAAGTTATGCGCCCTGTTACACCATGGCTGGACTTCAAAATTTTGATTATCCTATATAAACAAAAAAACACCATATTCTTTTTAACTCCCCAGCTTTATAACATGTTGCGTCTATATTTCTTAATACAAATCATTTAATAGTCTTGTAATCTGGCTTCTCGTTACAATGCTTGTAATCAAAAATCCCACCATTTCCACTTCCGTATATCTTGTTTTTCTAACGAAACATACAAAAGTACAACGTTTTTTACAATTTTCTACATAAAAACAGAAAATATATAATTCATTTACATAATTTTGCACTTTAATTTTTATTAAACAACAAATATTTTATTGATAAATAAAACTAAACATTCACTAATATATCTATACGTGGTTTAATATATATAATAAACAAACATTTCTGACTTTTATAAGGAGGTACTATGAAAGCAAACGTAGGCGATACTATACTATTTCAACGAAATAACTTAAAGATCACAGCATCTGTACTAAAACTATACACTGAATCGGTCTTAGTTGAAGTCACAGATGTAAGCGGTGGTACTTTTGAATTTGACCGAACAATTGTAAATCATAAAAACTATAAAATTTTAAATGCAAATAAATAAAACAATACAATACAAAATAGCCCCTGCTTAACAGCGGAGGCTATTTTGTATAATAACAATTCATTAATTTACATATCCTAAAACACTAACAATCTTGCTTGCTTTTAAATTATTAATATAATAATAAATTTCTAACCCTCTTCTCTCAGCTCTTAGCACTTTACCTTTCATTTTTGATAAATGCTGCGAAACAGTCGATTGAGGAATATTTAATATTTCTGTTAATTGTGTTACATTACAAGTTTTGCGTGCACTTAATTCATTTACAATTTGTAATCGTATTGGATGCGCCATTATTTTTAAAATATCCACATCTTCTTCAGTTACTAAACTTTTTTTTATCTCGCTCGTATATGTTGTCATAAGACATTCCCCTTTTATTTGAATTCCTTTTTATTAAAATCTGCTTCTAAATAAAATATTATCTCTAAATATACAATTAAGACCCTTATATAGAAATAATAGGATTTTGATTATTTAAAAACAGCAATACTATACAATTTCATCTATTTGGTACATATACATAATACAATTTCAATTTGTGCTCTATGTGAAGTTAGCATAAATTTATAATGAAGATTTTTCAAACAATTCACATCTAACTATATACTTCCTCATAACACTATCCAGTGATTTTAACATATTTTAGGCGTTTGTATATACTATTGCAAAACACATTAATATTGAGGGGGACTTTATATGCCAACACCGTCACAAGAACAAGTTGAAGAAGCTCGTGAAACATATGTCAGTCGTATTATTTTAGTTGGTGGTTCAGCTTTATTTTTAACAGGTGGTGTTATATCTGCAATTTCAGCCTTTAAAAGTTATAATCGTTTGGCAAATACGCCACCTTCTTCAAATGATTCATAATTGCATCATTCATTCCTTTAAATAATAAAGATGCCGCCTCTACTATAGAGACGGCTTTATATAAAAACATTATTAAATTCATTTGAACTTAATTGAAAAAACGTTATAACAATTTGGTACAATGTTCAAAGTAAGGATAGATACTTTCAATTTGACAAGCTTATTTCACCACAAACCTCGTCTGACTACACCCATCCTTCTGCTTCGTTACTTCTAATACAGCTGGCATTGCATTTTTCAGTTCTTGAACGTGTGAAATTACACCGATAAAGCGACCTGATTTTTGCAAGTCGATTAGGGCGTCAACTGCTTTCGTTAATGACTCTTCATCTAATGAGCCGAATCCTTCATCGATAAACATCGTTTCGATGGAAATACCACCCTCATACGCTTGAATTACATCTGCCATTCCAAGTGCTAAGCAAAGTGATGCGTTAAATTTCTCACCGCCAGATAATGTTTTTACATCTCGGGTTTGACCTGTATATGCATCATATACATCTAATCCTAATCCACTTTGTCGATTCCTCTTTTCAACTCGTTCGCTTCGTTTTAAATAAAATTGTCCATTTGATAATTTACGTAGTCGTTCGTTCGCAATTTGAACAATTTGTTCTAAATACTCAATTAAGATGTAACGTTCAAAGGATATACGACTATCGTTATCCCCTTTCATTACTTCATATAAATCAACAAGTTCTTGGAATGCTTTTTCTTCCTCATGAATTTGTTCATCAATTCGTTTAATATTTTCATGTAAATCCGTAATATATGATACGGCGTTTTGAGCACGTTGTCGTTTTTCTTTAATAATATCAAGGCTAATTTCCAATTCTTTCACTTGCTCATCTAATGAAGAAATGTCCATATACTCTTTATCTTTTAAGTCTGCTTTTAATTCTTCAATTTGTTTTGTAAGTACTTCTAGAGATGAGTAATAACTTTGGATTTCTTGTTGTAACTTATCCATCTCAGCATCATTTAATTTGGATTCTTTATATGTTAATTGATCTGTAAATCCGCTTTGTTCTAGCTCTTTCATAAAGCGTGTGAACGTCTCTTCTTTCTTCTCTTTTGCACTATTAAATTGATTAGAAGCATTATCATGTTCTGCTTGAATACGTATATTTTCATTTTGCCAATGTTGATACGCCTCTTGTACTTTCTCCCATTCATCTTCCATTAACCTAAGTTCTTGCAGAGCTTGGTCAAACTGTACTTTCCAAGCTTGTACCGTTTGCAAGCTTTCCGGAATATTTTGCTTATCATGTTCATATGACGTACGAAGCTGCATACACTCCATTTCAGTACGGTGCTGCACAGTTTCTACTTCACGCTTTTGTTTCTGGAGTTCTTCTACTTTTTCTTCTACGCTTTTTATATTCACAGCAATTTGCTTACGCGTTTCTTCACTTGCTTTTAACGCATTAACTTCTGCTGCTAATTGCTTTCCTTTTTGAACGAGCGCACTATATGTTTCTACTAATTCTTCTGAGCGATAGCCTCGCTTTAGCACTTCTTCTATCACTTGTTCATATTGAACTCGATAGAAATTCCACTTTTCTTCTAATTGAACATGTAATTTTTCCGCAATAGTTTTCTTTTCTCTTAGCTCATTTAACTCTTTTTCATCAATTGCATTACTTTGCTCTGTAGCTTTTTTCGGGTGGTCCATACTACCACATACTGGACAAGATTCACCATCATGTAAATGAAGAGCTAATATACCAGCTTGTTCACTTAACCAGCGGCGTTCCATATTTTCATATGTACTAACTGCCTGTTGCATCTTATGAAACGCACTTTCTTTTTCTAGCTCGTATTTTTGTTTTTCTTGCCATACATCATATGCCTGCTTTAATACTTTTGCATCTTCTCGCATATTCGTTAGTTCTTCTACTTTAGCTACATATTGTTCAAGCGCTGCTTCTAATTGCTGTAATTCGCCAGACATTCTTTGTTTTTCATTTTTATACGCTTCTAGTTGTTCATCTAACTTTTGCATACCTTCTTTTAATTTTCCTATGTGAATTTCAGCATTTTGCAAATTTAACTTTTTCTCAGCTAATGATGCAATAATTGGCTGTAACTCTTCTAGTCTTTGAACTTGTTTTTTAGCATTTTCTCGCTCGGATGCCTTATTCTTTAATGCTTCATATTTCTCCTGAGCAAGTGCAAAACTGTTCATTATATGCTCTTTTTTTGCGATTATCTGTTTTAACAAACTTTCAGACTGCTGTTCATATTGCATCGCTTCCTCATGCCATTGCTCAAATGGTAATAATCGCTTCGCCTGTTCCGCATGTTTAAAAGATTTTTCTTTCATTTCGATTACGGCACGGTTTTCTTGTAAAATACTGTACTTCTCATTCTTTTGTTCTAAATCTTTGAATTTCTCATTTACAGCTTTTGCTGCATGAAAACGTGCCTCTGCTTCTTTTAATTGTTTCGTTTTGTCATTTTGTTCTAAGTGTAATTGCTCAACCTCTGCATTGTACCAATTTGTTTCTTGTTCTAATGCCTCTACTACTTGATGTGTATTTACATGCTCTTGCTCCACTAATGTCTCTAATAATGCCCCATCACGTATTGGTAATTTAAATACATTACGGAAATATAGCTCACGTTCTTTTTGTTTTTCTTGTAAGACGTCTTTCCATTGTTTACGCTTTTGATCTAATATCTCACGCATTAATTTATAACGATCTGTTTTAAAAATGCGGCGTAGTATTTCTTCTTTATTTTCCGTTTCAGATGTTAATAATTTTCGGAACTCTCCTTGCGGTAACATGACAATTTGGCTAAATTGATGTTTACTTAATCCAATTAAATCTTCAACTTTTTTATTTACATCCGTTACATGAAAACGATCGACACATGGAACTTTCTCCTCATCAATTACTTCATATAATTCGACTGCATGTCCTGTAATTGTTTTATTTCCTTGTTTTTTATGGCCCAGTTGTCGTTTAATTTCATAACTTTTTCCTTTTAATTGAAAAGTTAATTCCACACTTGTATAAACATCATCATCAGCAAATTGGCTACGAAGCATGTTAGTATCACTGCGCTCTTCTCCACTAGCTTCTCCATATAATACATAACAAATTGCATCAAAAATCGTTGTCTTTCCAGCTCCTGTATTTCCAGAAATAGCGAAAATACGATGCTCACCAAGATCTTTAAAATCGATTACTTCTTTCTGTTTATATGGACCAAACGCGGTCATTATAAGCTGAATCGGTCTCATCCTCGCTCACCTTCCCGTTCTTGCACTGTTTGCAAAACATCTAAAAATAGACGTTCTTTCTCTTCTGGTAGATCTAGCCCTTTCATTTCTTTATAAAATGCTTTTAAAAGAGATAAATCATCCGTTTTATGTCTTGAAACAGTTACTTCATTTTCATCTGTGAACTCTCGTCTTTGAATAGATCTTTCAACATGCATTGCATTTGGGTATACAGAACGTATTTTTTCCATTGGCTGCAAGACAGGATTTTCATCTAATAATTTCACAAATACATAATCTTCACTCACTGGATGAAGCAATAAATCGTCTATTTTCGCTTCTACTGTACGCATTTTACGACGTGGTGTAAGTAAACGTTTTTCAATTGTTGTTTCACCTTTTTCATCCAGTTCCACAATATAATATCCTTTTTTATGCTTTTCTTCAGAAATAGAATATGCAAGTGGTGAACCTGAATAACGAATTGTCTCATTACGTACAAAATGCGCTTGATGTAAATGGCCAAGCGCCGTGTAATGAAATTTATCAAAATAATGGCTATTTACATATTCAGCACCACCAATTGAAAGTGGTCGTTCCGCATCACTCGTATTTTCCTCTGCCTCTCCTGAAGAAGTTACAAATGCATGTCCTACAAATATGTGTCTCGCTTCTTTATCCATCGTTTCAGAGAGTTCGTTCATAAAAATACGCATCGCATCATCATGAGAACGAACATCTTCATTTTTCAATATATGTCTAACAATACTTGGATCTGCATACGGAACGAGATGGAAATGAACCTCTCCGTATTCATCATTTAAAACAACGGGATTGTATGGAAACTGGAATTGTCCAACAATATGTAATCCTTGTTTTTTCATTAAATTACTACCAAAATGTATGCGGTCCGGACTATCGTGGTTTCCTGCAACTGCGATTATTGGTGTTTGTAAATCAATAACTATCTTTTGTAATACATCATTTAATAAGTCTACTGCTTCTGTAGGTGGAATTGCTCGGTCATATAAATCTCCTGCAATAATTACAGCATCCGGTTTTTCCTCTTCAACAGCTTGTACAAACTGATCTAACACAATTTTTTGATCTTCAGTCATATATACACCATGAACAAGCTTACCTAAATGCCAATCCGCTGTATGAAAAAACTTCATATTACCCTTCTCCTTTTAGTTTACTGATTGTAGTGAAACAAGCTGATAGTTTAGTGTAGTTTTTCCGTTCTCCCATTCTAACTTTTGGACAATTGCACTACCGATTCTTTCTTCGTTTGATTTATATAAAGGCAATATTTCTTGAATAGTAAATAGATGATAACCATCTAAAATTAATTGAAATAAATTATCTTCTATATGTAATCTTACTTCTTTTTCATTTGAAATAATTTTTGTATGCATCTCAAATTTCATGCTAGATACAACCCCTTTTTTCTAATCTCTACATTTTAATAGTATAGTGGTCATGCAAGATTGACAAGTAAATACACCGGGATGCACATACTTTTTTAATTATAAATATTTTATGTTTTTTTATATGAAATACGGTATGTGAAATTATTAATCTACAAAAATAAAAATGCCCTTTCAGGCATCCTTATTTTTGTAAGTACTCTTTCATAACGTAGTACAATACAGTTATTAAGACAATCGCTACAAAAAACGCAAATACGGCCACAACATACCCATCTTTATTTAATAAAAAGCATATGGAAATAGATATTATAAAAATCGGAAACACGAGACGTACCTTAGCCTTCACTTCTTCTGTCGTATCTGTATGATGAAAATACTGTGTAATTCCTACCATAAGAGATGACAAAATAATAACCGACAATAGTAAAGGTCCTGGCATTCCGATCTCTCCTTTCTCTATTTCTAATTATATACAAACCCCGCGCTCTTTAAAAGTTAGATAATTCAGCCTTTTAACTTTTTCTACATCCACTCTTTAATTTACACCACGTATACTAACTCAATATAAGTTATACATATAATAGCGCCTTCAACACGACATTTTCAAATAATAGCACTTACAGTAATGTTGTAATATTCCTCTTCATTCTCTGAAATCCTGCAAATATAACTCGTCAAAATATGCGATAAGTACTAACACTAAGCACCTAATTTAGACAAAAATTATAGAGGACATTTCAGCATGTATCAAGAAATAAGAATAGAAAGATAAGTAAGGGAGGATTTATAATGACTGAACACGTTTTATTTTCTGTTAGCGAAAACGGCGTTGCATCTATTACTTTAAACCGTCCAAAAGCACTTAATTCTTTATCCTATGACATGTTACAACCAATTGGGCAAAAACTTAAAGAATGGGAGCAAGATGAGCGTATTGAACTCATCGTTTTAAAAGGAGCTGGGACGAAAGGTTTTTGTGCAGGTGGTGATATTAAAACGCTATACGAAGCACGTTCTAACGAAGTTGCATTACAACATGCAGAGCAGTTTTTTGAAGAAGAATATGAAATTGATACATTTATTTATCAATACAAAAAACCAATTATCGCTTGTTTAGATGGAATTGTAATGGGCGGTGGTGTCGGTCTGACAAATGGAGCGACGTATCGAATTGTAACAGAGCGTACGAAGTGGGCAATGCCTGAAATGAACATCGGTTTCTTCCCGGATGTCGGTGCTGCTTATTTCTTAAATAAAGCGCCTGGATATACTGGTCGATATGTTGCTTTAACGGCATCTATTTTAAAAGCTCCTGATGTATTATATATTAACGCTGCTGATTACTTTATGACATCAGATTCATTACCAAATTTCCTTACCGCACTTGAAAATGTAAATTGGAAAAAAGAAGATGTACATACTCATTTAAAAGAAGTTATTCGTACATTTGCAACTGCTCCAAACTTAGATGGCAATCTTTCTTCTTCAGTAGAAGAAATTAATTCGCATTTTGCATTCGATACAATTGAGGGAATCATTCAATCGTTAGAGAAAGATCAAAGTCCATTTGCCCAAACAACGAAAGAAAAGCTATTATCCAAATCCCCTGTTTCATTAAAGGTAACATTAAAACAGTTTATTGATGGCCAAGAAAAGTCAGTTGAAGAATGTTTCGCGACAGATCTTATACTCGCTAAAAACTTCATGCGACATGAAGATTTCTTTGAAGGAGTACGCTCCGTTGTAGTTGATAAAGACCAAAATCCAAATTATAAATATAAACAATTAAGTGATGTTTCAGAAGAAGATGTAAATCGATTCTTTAACTTACTTAACGCTTAAGCAAAGAGGCCATATATTGTAGCACACTCTCAGCTACTCTATATGGCCTCTTCTTTTTAGTTAAATAATTTTAAATATAATTTAATTTTATTTAACTAAAATGTATGTTAAACTAACGTTAATCGAATTTTCTAAAAACAAAAAAGGAAGGCGGATAACATTATGGAAGATTTTTTTCTGTTTATTATTATGTCTATATGTCTTATTATTCTACCCGGTCCTGATACAGCAATGGCTACGAAAAACACATTGATTGCCGGCAAAATCGGCGGCGTAAAAACTGTTTTTGGTACTTGTGTTGCGCTTTTAATTCACACTTTAGCTGCTGTAATTGGTCTTTCAGCACTTATTGTAAAGTCTGCTCTTTTATTTTCTATTTTTAAATATGTTGGTGCTGTATATTTAGTCTATATTGGTATTAAAGCCCTTTTAGCAGTAAGAAACACAGAAGACTTAAATACAAATGACGTTCCAATAAATAATGACAATAAACATACTTCTTGCTTTCGCCAAGGGTTTCTTACAAATTTACTAAACCCTAAGATTGCAGTCTTCTTTTTAACTTTTTTACCACAGTTTTTAAATCCAAATCATAATACATTTATACAACTTCTCGTTATGGGACTTACTTATCTCATTTTAACCGTCATTTGGTTTGCTTTTTATATATTTTTAATTGATAAAATTAGTGCTTTTATGAAAAAACCGAAGACACAGCGTTATATTCAAGGGATTACAGGAATCGTCTTAATTGGGTTTGGTATTAAATTAGCCTTTGAAAGAAATAGTTAACACAATACAAACGAAAATACACTACTCGATTATGAGTAGTGTATTTTCGTTTGTATTATTTTTATAATGAGTGGGAATGCACCCCACTCATTATCATTTCACTTTATTAAAACCAGCGCTCAGTTACAACTTTTTTACGTGTATAAAATTGAACGCCATCCGTACCATTTGTACCAAGATCTCCAAAGAATGAAGCTTTGTTTCCTGCAAATGCGAAGAATGCCATTGGTGCTGGAACATTAACGTTTACACCAATCATACCAGCATCAATATTGTCTCGGAATGTTTGTGCATGTTTTCCATTTGATGTATAAATAACAGCACCATTCGCAAATTTCGATTGATTTGTCAGCTTAATACCTTCTTCTAAATCTTTTACTCTTACAATACTTAATACCGGAGCGAAAATTTCATCTTGCCAAATTTTCATTTCTTGATTTACACCATCAAAGATTGTTGCACCAACAAAGTAACCTTCTCCAACTTCTTCATTGATTTTACGGCCATCTACTAGTAAAGTTGCTCCATCTGCTACACCACTATTAATATAGCCTAAAACACGTTCTTTATGAGATTCACGGATTAATGGTCCAACATAATTATCTTCGTTGAAACCGTCACCTACTTTTAACTTCTTCGTTTCCGCTACTAATACATCAATGAATTCATCAGCAATTTCATCAACTACTGCTACTACTGAACATGCCATGCAGCGCTCTCCACTACTTGCGAACGCAGACCCAATTACACCTTGTACTGTTTTCTCAAGGTTGCAATCTGGCATAACAACCGCATGGTTTTTCGCACCTGCTAACGCTTGTACACGTTTACCATTTTTTGTACCAGTTTCATATACGTAGCGTGCCACTGGCTCAGAGCCAACAAACGAAACTGCTTGAATATCTTTATTTTCTAAAATACTATTTACAACATCTTTTCCGCCTTGTACTAAATTTAATACCCCTTTTGGAAAACCAGCTTCATAGAATAGCTCTACAAGTCGCTCAGCTAAAAGTGGCGTTCTTTCAGATGTTTTTAATACGAATGTATTACCGCAAGCAATTGCAAGTGGGAACATCCATAATGGAATCATCATCGGGAAGTTAAACGGTGTAATACCAGCAACAACTCCGATTGGGTAGCGCCAAATCGATCCATCAATTCCACTAGCAATATTCGGAAGGGCTTGTCCCATCATTAAATTTGGTGCTGATGTTGCAAGTTCTACCGCTTCAATACCACGCTGTACTTCACCAGTTGCATCCGTTAGCGTTTTACCGTTTTCTAGCGTAATGATTTTTGCAAGCTCTTCTTTATTTTCTTGTAACAGTTGTAGATATTTGTATAGTTGTCTTGAACGATTTGGAACTGGCACTTTAGACCATGTTTTGTATGCCGCTTTTGCCGCTTCAACAGCTTTTTCAACATCTTCTTTTGGAGAAAGTGGAACGTAAGCGATGATTTTTCCGGTTGCCGGATTCGGAACCGCTTCTACTTCCGTACCAGTAGATTCTACCCATTCGCCATTAATATGATTTTTCACTCGTTTAATTTCAGTTGTAATCATTATATTCTCTCCTTTTTTATCATGGTTTTTATAAGTGCACTATTTTTGATTAGAAATTAATTGTTCGCTAACTTTCTTATATAAAGCAGCCATATCGTTTTCACCATATCCTGCCTCACTCGCTTCTTCATATACGTTTAATAGCATCTCACTTACTGGTAAGTGAAGTTCGCTTTCTTTCGCTAAATCTACCGCAAATCCTAAATCTTTCTTTAATAAATTCACAGTAAAGCCTGGCTCATAATTTTCTGATGCAATGAAACTTTTATAATTACGCTCATAAATTCTACTTTGACCGTAACTTACATTTAAAATTTCAAACATTTTATCTAAATCCATATTGTTCTTTTTCGCTAATGTTAAAGCTTCACTCACACCAGCTGTATAAAAACCAATTAATAGATTATTAATTAATTTAACAGTTGTACCACTATCAATCTGCTCACTAACATGGAAAACATTCGCTCCAAGCACTTCCATGACAGATTCAGTTTTCTCATACACTTCTTTCGATCCACCAACCATAAACGTTAATGTACGGTTTTCTGCACCAATTACCCCACCGCTAACAGGTGCTGCTAAAAAGTCTACTTTCTTTTCCTTCGCCGATTCCTCTAATTGTTTGTTTAATTGTGGAGATACTGTACTTGTATCAATTAAAGCTACATTCGAGTGGCTATTTTCAAATAATCCTTCTTCCCCAAAATATACCGCTTCAACAGCACGAGGTGATGGTAAGCTTGTAAAAATCACATCGCATGTCTCTGCTAGTTTTGAGATTGATAGGCCGATAATTCCTCCTTCTTTTTCAAAGGAAGCTTCCGCCTCTTTATTCAAGTCCACTCCATATACTGTGTAGCTAGATTTAACTAAATTTTTAGACATTGGAAGACCCATGTTACCTAAACCGATAAAACCAATCTTTTTCATATCGCTTTCCTCCTATTTACACAATATATTTCCCGCGATTTATAATAACTTTCGCAATATCTCTCTTTTTCGTAAATAAGTTTGAGTATAAAGGCACTAATAATTGACGGATTTCAGCTAATATTTCTTGTCTATTTTGTTCTTCTGTGACAGCTGCTGAAAGAATGGAAATCGCGGATTCTTCTACTTTACGATATCCTTCTTCACAAATAACATCTGTTATCATTTGTTTCGTACGCTCTTTTTCCTCACCATTTTTACTAACTGCTTTCCTCGTACGTAAAAATGCTGATTCCATGACGTACACGTCCGTCAACATATTTGATAATACGCGTGAATATTCTTGCTCTTGCTCAATTTTTAAACCTGGAGTTTTAGAGAGCGTTTTCAAAGATTGTTTCAACAATTTTTTCGCTAATAAAATGTAACGATGGTTTCTTTCTACATTTGCCACATCAATTTCTACTTCAGCATCTTCTATTTGCTCGATTTGCTTCATTAACATTTTTGCAACTGTTAATCTATTAATTTCATTCGTTCCTTCAAAAATACGACTAATCCTAGCATCACGATATAATCGTTCTACTTCGTATTCTTGCATATAACCGTAACCACCATGAATTTGTACAGCTTCATCTACGATATAAGCAAGTGTTTCAGAAGCGTTTACTTTATTCAGTGCACATTCAATTGCAAATTGGGACATTTTTTTCATAAGATCTTCATCACTCTCATGAATTGCTTCATCAATTACACCCGCTGTACGGTAAGCTGCACTTTCTGCTCCATATGTAGAAATAATCATATTGGCAATTTTCTCTTGAATCATCGTAAAATCTACTAATTCCGTTTGGAACTGTTTTCGCTCTTTTCCATATTGAACCGATAAACCAATTGCTTGTTTTGCTGTTCCAATATTTCCAAAAGCCAGTTTTAGTCTAGCAAAGTTAAGGATATTAAGAGCTACGTGATGCCCTTTCCCAACTTCCCCTAAAACATTTTCAGCAGGGATGACAACATCTTCTAAAATAAGCGTCGCTGTTGAAGAACCTTTAATCCCCATTTTCTTTTCTTCTAGTCCAATGGATACACCTTCACATGTTCTTTCGACAATAAACGCTGTCATTCCTTTATTTGTCTTCGCAAAAACAACGTATACATCTGCCATATGAGCATTTGTAATCCACTGCTTCTCACCATTTAACTTCCAAGCAGTTCCATCTTCATTCAATACTGCACTCGTTTTTGCACTTAATGCATCAGAACCAGCATTTGGCTCAGTTAAAGCATAAGCCCCAATCCATTCTCCAGACGCAATTTTCGGCAAATATTTTTCTTTCTGTTCTTTCGTTCCATAATATATGTAAGGCAACGTACCTACACCGGCGTGTATATTAAAAGAAACGCTAAATGCACCAGCGTAACCCATTTTCTCTGCTACAAGACCTGAGACAGCCTTTCCTAACTCGAATCCGCCATAATCTTCTGGTACCTCAATGCCTAATAATCCAAGTTCCCCAGCTTTCTCAAATAATTGACGAGAAACTTTATAGTTATGTTGTTCAATATTCTCAATTTGCGGGACAATTTCTTGTTTAACGAATTGTTCTGTCGTTTTTGCAATTAAATCTTCATCCCCTGAAAAATCTTCTGGTGTAAAGAAAGTATTATTCACATCTTTATTGAGTGAAAAAAATTCATCCCATGGTAACTTCGTTTTCTCCATCTGAATCCCCCTATCATTTCGGCCTTCGTTGATTTTTGCATATGCTCGTCTACGATGAGTGGAATATCTTATTATTGAAAACAGAAGGCGATGATTTTTCACATCAAGCAGTTCGTTTTGCCAAAGATGTATTTTCATCGCCTAAATCCTTCTACCTATTGATCTTCAGATAATACTGTTTTTGCAATTCCAGTATCTAACTCTTCAAAGTCATGATATGAAATTGTTTCATATAATTCACTTCTCGTTTGCATATTAGAAAGTGCATCTTTTTGAGAACCCGTTTCCTTAATTAGCGTGAACACATTCTCATATGCTTTTGCAGCAACACGAAGTGAAGTTACAGGATAAATTACCATTTGGAAGCCCATATTCGCAAATTCCTCTGCACTATAATATGGTGTTTTTCCGAACTCAGTCATATTTGCTAGTAAAGGTGCATTCACTTTGCTAGTAAATAAACGGAATTCTTCTTCCGATTGAAGCGCTTCTGGGAATATTGCATCTGCCCCTGCTTTTACATATGCATTCGCTCTTTCAATCGCTGCATCTAATCCTTCCACGCCGCGAGCATCTGTGCGTGCTACAATATATAAACTTGGCGCAACTTCTTTAATCGCTTTAATTTTTTGAACTAATTCTTCTGTAGTAACAAGTTTCTTACCATTTAAATGTCCACATTTCTTTGGTAATTGTTGATCTTCAATCTGAACAGCCGCAACTTTCGCTTCCACCATTTCTACAGCTGTCCTCGCTACGTTTAGTACTCCACCAAATCCTGTATCAATATCAACAAGAACTGGTAAATCTGTAGCTCTAACTAGATCCCTTGCTCTCTCTGCTACTTCAGTAGACGTCACGATTCCTAAATCTGGTAGTCCTTTACTTGCAGTGTAAGCAGCTCCCGATAAATATAGAGCTGAAAAACCTGTGTTTTTCGCAACAAGAGCCGCCATTGCATCATGAGCACCTGGAATTTGCAAAATTTCATTTGCTTCTACTAAAGCTCGGAAGCGATTCGCAAGCTCCTCTTGTGTTGACTGTTTATTCACAACCCAAGCCATTCTAAATTCCCCCTATTATTAAATTAAGAATAGATCTACAAATTCGTTTACATTCATATTTTCTAGTTTTTCTTCATTTAGACAAGCATCATGGATTTTTTCTTGTTGCTTACTAGAATAATGACCTGCCATATTTGCAGTGAATTTTCGAACAACTTTTGGAATTGCTTCGTCTCTACGGAAACGGTGGCCAAGTGGGTATTCACATTCCACATTTTCTGTTACAGTACCATCTTTAAAATGAACTTGAACAGCGTTGGCGATTGAGCGCTTGTTCGGGTCAAGGTAATCTAAACTGTACTGTTTGTTTTCAACAACAACCATCTTATTACGTAATTCATCTACACGTGGATCATTCGCTACTACATCCTCATAATCATCCGCAACGATATCTCCTTTTAATAAACCTATTGCCGTAATGTATTGTAGGCAGTGATCGCGATCAGCTGGGTTATTTAATGGACCTTCTTTATCGATAATACGAATTGCTGACTCATGAGTTGTAATTGTAATACGATCAATTTCATCTAATCTTTCTTTAAGTTCCGGATGTAATTTCACTGCACATTCTGCAGCTGTTTGTGCATGGAATTCTGCTGGGAATGACACTTTGAATAATACATTTTCCATTACATAAGATTCTAGCGGTCTTGCTAATTTTAATTCTTGCTTGTTAAATAACACATCTTGGAATCCCCATCCTGGTGCAGATAATGCCGTTGGGTAACCCATTTCACCTTTTAATGCAGTCATTGCAAGATGAACACCGCGGCTCGTCGCATCACCTGCTGCCCATGATTTACGTGAACCTGTATTTGGAGCATGACGATATGTACGAAGACTAGAATTATCAATCCACGCATGTGATAATGCATTAAAGATTTCCTCACGCGTTCCGCCAAGCATTTTTGCAACTACTGCAGTCGTCGCTACTTTTACGTATAATACGTGATCAAGACCAACACGGTTTAAACTGTTTTCTAAAGCAAGTACACCTTGAATTTCATGTGCTTTAATCATCATTTCTAGTACTTCACGTACTTTTAATGGTTCTTTTCCTTCTGAAATACGAACGCGGCTAATATAATCTGCAACTGCTAAAATTCCGCCTAAGTTATCCGATGGATGTCCCCACTCTGCTGCAAGCCAAGTATCGTTATAGTCTAACCAACGGATCATACATCCGATATTAAATGCGCCTTTTACTGGATCTAGCACATAAGATGTTCCTGGTACACGTGTACCATTTGGCACGATTGTTCCTGGTACAACTGGTCCTAATAATTTCGTACACTCTGGGTATTGTAGTGCTAAAATTCCACATCCAAGTGTATCAAGTAATACGTAGCGAGCCGTACTGAATGCCTCTGCACTTGTAACCTCTTTATTTAATACATAGTCCGTAATTTCTTCTAATAATGCATCTTTTTGTTTAATTTCATTTGTTTTAATCATGCTATTCTTCCCTTTCTGTCGAAAATTCGTTATTATTAATGATGGGTGTCGGTCAAACACCCATCTGGCGGGCGGCGCTAACAACTCCCCAGTTGTTTTTATTTACTAAATGCATGTCGCTCGCCAATATAATTTACACGTGGACGGAACAAACGATTGTTCGCATGTTGCTCAATTACGTGTGCACATAGCCCTACTGTTCTAGAACTAAAGAAGATTGGTGTGTAAAGTTGAATTGGAATACCAAGCATCCAATATACTGGAGCAGCATAATAATCAAGATTCGGATAAATTCCTTTTTCCTTCTCCATAATTTTTTCTCCAGCTTCACACATTTCATATAGTGTATAATCGCCTTTCACATCACATAACTGCTTTAATGCTTCCTTCATCATAAGTGCTCTTGGATCCATCTTTTTCATATAAACACGGTGTCCAAAGCCCATAATTTTTTCTTTGTTATATAGTTTCTTCTGTAATAACTCTTCAAATTTCTCAACATTACCAGCTTCTAAAAGCATGTACATAACCGCTTCATTCGCACCGCCATGAAGACTTCCTTTTAAGGATGCAACTGCTCCTGTTAAAGCGCCGTATAAGTCGGATTGCGTTGATGCAATAACGCGTGCTGTAAATGTAGAGTTTGGCATTTCATGTTCACTATATAAAACAAGGGAACGATCAAAGATTTTCTCTTCAAGTTCAGTTGGTTTCTTTCCAGTTAACATATAGAAGAAATTCGCACTATATGACAATTCTTGAAGAGGCTCAATTGGTTCCTCATTATTTAAAATATGGTAGCTATTCGCTACAATATTTGGCACTTTACTTAAAAGCTTGTATCCTCGACTTTTATTCACTTCTAACGAGCGGTTTTCGATATCACTATCGTAACCAGCTAATGCAGACACACCTGTACGTAGCCCATCCATAGGATGCGTTTCCTTAGGCAATGCCTTTAGAACATTGAATACACCTTCTGGCACTGCATATTCTTCTTTTAATTTCTTTTCAATTGTTGCTTTCTCATCCTCATTCGGTAAACGTTCTTCTAATAAAAGGTGCACAATGTCTAAATACTCTTTTGTTTTTGAGAGTTCGATTAAATCATACCCTTGAATTACAATTTCACCTTTTACTGTGTCAAGAAACGAAATTTTCGTTTCCGCTGCTACTACACCATCTAATCCCGGGGAAAATTTTTCTTCAGCTTTCATCATTATTTCCTCCAATCCTAATAGATCTTCGTGCACATAACTGTAAGCCTTTACAATAATATGAAACTACATTTCTATTTCAATGTATCAGAGTTTTTAGAAGATTTCAATTTATTTTATAATGATAAGTTTCCTATACTTTTACCGATGTAATAATACAATTTTTCAAAAATAACTTTCATCTTTTATAAAGAAAGGACAGACATCCTTTTACAATGTTTTAAAACGAAATATAACAATTATCCATATAATCCCACTAAATATACCTTTAATCCCTTTTTCTTCAACAAACATAAAAAACCGAGCTGCACTCATGCACAGCTCGGTTTTTTATAATATTTATTTCATATTCCCATAAATATAATTCTTATATAAAATTTATTTATTTTTAATAAAATTATTATTTTACATAATTAAATTAAATTTCTTCCGTTTCTTTACGATAGCTTACAACTAATTCATAGTTTTGAAAGTACGAAAGATCATCAAAATCTATAAAAATAAACTACCGTCTTTCTCAACTGACACTATTTCCCGAACTGATTTCTCAGAAACAATCCCTAAAGAATATCCGGGCTGAATTGAGCTATTTCCTCCGTACCTTACAATACATCAAATAGATTCATCATGCTTTATACGCAAAATCTTTTTTGCCTAATCGTTGTTTTACAAAAATGACAAATATAATTAAAGCTATTAATCCTGAAATTGCACTACCTGCAAATAAAATACGGTAACCAAACATTTGTGAAACTACTCCAAGTAAAATCGCACCTAATCCAATCCCTAAATCAAAAGCGGTAAAGAATGAAGCGTTAGCAACTCCTCTTTTACTAGGATCAACAATTGTCAGCATCGCTGCTTGTAAAGCGGGCTGTGCTGAACCGAATCCAACACCATATAATGCCGCTGCAATCATTACACCTATCAAACCATTTGAAATCGTTAGTACAACTATCGCTAAAATAGTAATACATAGTGCCGGAAGTATGATAAAAACTTCTCCATACTTATCTAATAGTTTTCCTGAAATAGGTCGTACAATTGTTAAAGCAATTGCATATACAAGAAAGAATGTCCCAGGATTCACATCAATTGATGACGCGAATAACGGTAAAAATGTTGTTATTCCTCCATATGCAAATGATAAAAAGAAAACAACAACCGTTATTGATAAAACGGATTTTTCAAACAGCTGAATTTTCCCTTTTTCTTTTTGTGGCGTGAATGGCATTTTCGTTATTAACGATAATACGACTGCCATAAAGGATAAAAGAGTTGCTAACAAGAATAGACCATGAAATGAATAATTTTGTACAACCCATAATCCAATCATCGGGCCAATTGCCATCGCGATTGTCATCGCCATGCCATACCAGCCCATCCCTTCACCACGACGTGAATCTGGAATAATATCAGTTATCGCTGTTCCAACTGCTGTTGTAGAAACAGCCCACGTCACTCCGTGAATAACGCGTAAAACAGCTAAAAGGACAATAGTCGATGCTAAATTATACGAATACATCGTTATCCCAAAAAATATGAGTCCGAAAATAATAAAAGATCTTCTACCATATTGATCTAGCATACCTCCAATAATCGGTCGTATTACAACTGCCGCTATTGTAAACATTCCCATCATCAGTCCAACTTGCGATTCATTTCCACCAATCTCTTTAATAAAGAGCGGGAGCGTTGGAACAAGTAAATAAAACCCCGTAAATAAAAATAACATCGCGATAGTCATTTGTATAAATGATTTCGTCCATAATCGTTCCATTAAAATCCCTCCATAAACACGTAAAATATTACAATCAACACATCAATTGTATATTTTTCATGTTCCCTTGCCCTCCGCTAATAGACGTATCTTTTCATAATAAATGGTCTACCATCAATTTAAGTTGGTCTTACGACTTTATGCCTATGTTTTAAGCAAAAAACCTATATATGTACCTTTATATGTTTTAGAAGAATATACTATTTTATTATTAAACTTAGGAGTGATCGTTTTCATGTGGGTATCACCAAGAATAACCGCCGTTGTCCCATCAGCTCCCTCAATACATGTTCCTGTCGTTCATACAGCTAGTTCTGATGTTGGTATCGAACTTCCTGCCGCTTGGCAACAATATCAATCGACTGACCAAGTCACCCCTTCATTTTGGCATCATGGTACACACCCGAGTAGTACTACTTTTTATGGCCCTAGTTATCCAATACCGCCAACTCAAATTTTTTATCATTTCCCATCAATTTACTTTCAAAATTTCTATGGTACTTTTAATATTTAAAAATAATATTACTCTTTATAATACAAAAAGCACCAAAGAAACCGTTTTTCCCGGTACCTTCGGTGCTATTAAAATGCATTATTTATTGTCCATTATTGGAAGGAGCCTCTCCTGTGTTCCCGCCAGTAGTTGGTGGATTTGGAGTTCCTTGGCCACCTCCAGTGGTTGGTGGATTTGGAGTTCCTTGGCCACCTCCAGTGGTTGGTGGATTTGGAGTTCCTTGACCATTTCCATTGTTTTGTTCATTTTGCTTATTCTGTTCATCTTGTTTCTTTTGCTCTTCTTGCTTCTTAAGTTCATCTTGTTTCTTTTGCTCTTCTTGTTTCTTTTGCTCTTCTTGTTTCTTAAGTTCTTCCTGTTTCTTTAATTCCTCTTGATTTTTCTCTTCTTCAGTTTTTTGCTGTTGATCTTGTTTTGGTTGTTCCGTTGTATCCGGTACGCTCGTATTTGGAGATGAATCACGTTTTTCACCTTTTATACGCAATTCACTACCTTCTTGAATAACACTACTTGGCATTTTAAAGCGTGATTTATCTGTAGCCATCTCGCTCATCATTTCTTTAAAGATCAACTGTGCAATTTTCGTATTTTTACTACTAATATACTCGTCTTTACCATCTTTCGTATATCCAGTCCATACTGCCATCGTATATTGCGGTGTATATCCTGCAAACCAACTATCACGAGTTGCACTTTCTGGAATTCCATATTGTGCTAGTTGTTTTGAAGAATAGTTAGTTGTACCTGTTTTACCAGCTACATCTAAAGAGGCCACATTTGCCGATGTACCAGTACCTGATGTAACTACAGAACGAAGCATATCAGTAATCATATATGCTGTAGAATCCGCCATAACTGATTTTGGTTTTTGTCCAAAACTTTGTGACTTGCCGTCTGGATAAACTACTTTCTTAACAAAATGCGGCTTCGTATACTTACCGTCATTCCCAAATGCCGCATAAGCACCTGCAATTTCAGTTGGTGACGCTTCATTTGTACCGATCGCTGTTGATTCTGTCGGTGCTACATTAAATGTAATACCTAATTTCTCAGAGAACTCTTTCGATTTACTAATACCTACCTCTTTAGCTGTTTTAATAGCTGGGATATTACGTGACTTTGTTAGTGCTTCACGCATTGAGATTGGCCCTAAATGACTTCTATCTGCATTTCTAACTTCTTGGCCAGTTGAATACTTAAATGGAGAGTCATCAATTTGATGATAAGTAGCCCATTTTAAATATTCAATTGCAGGAGCGTAATCAAAAATTGGTTTCATCGTTGAACCAGCTGCACGATCTAATTCAATCGCCATATTATGCCCTTTAAATACTGCTTTATTTTCACCGCGCCCACTACCTATAGCGCGAACTTCTCCAGTTTTCGTATCCATAAATGTGAAAGCACCTTGGAATTTATCATTTGGATAATTAATAATATTTGTATTCAAAATATTATCAGCTAATTTCTGTGCTTTCGGGTCTAATGTTGTATAGATTTCTAAACCATCTGATCCAATATTAACATCTGGTATTTCCTTTTCTACTTCTTTCACAACTGCATCCATAAATGCAGTATGAGGCATTGCTTGAACAGTTGCAGTCTTAAGTCCATCTGTTACTTTAACTTTCGAAGCTTCTTCCATTTCTGCCTTTGTAATATAACCATGTCTATTCATTAAGTTTAGTACAGTATTTCTTCTTTCTGTTGCCCTTTGAACATTTTCTTTTTTCGTTGGGTCATAGTTATTCGGTGCTTTTGGTAAGCCAGCTAGCATCGCAACTTCTGGTAATGTTAAATCTTTCAATTCTTTACCGTAGTAGTTTTGTGCTGCTGTTGCGATTCCATATGAACGGTTTCCTAAATTAATTTTATTTAAATACATCTCTAATATTTCATGTTTTGAATATTGTTGTTCTAGCTTATACGCTAAATATATTTCCTGAACTTTACGTTTTGACGTTTTTTCCATCGATAAGAAGTAGTTTTTAATAACTTGCTGCGTTATCGTACTACCACCTTGAGAGCCATAATCTCCCTTAAGACTAACTAAAACTGCACGAGCAGTACCTTTAAAATCTACTCCGCTATGCTCATAAAAACGCGAATCTTCTGTTGCTAAAAATGCATTTTCTACCAATTTAGGGATTTGATCATACGTAACATTCGTCCGCTTTTCTTTCCCATATTCATATACCAAATTCCCGTCTTTATCATAGATTTTTGAGGATAACGGATTAACAAGTTTTGCTTTCTCAAGTTTTGGTGCATCCTTAATCATTACGAAAAAGGTAGCAACCCCTGCCACTAAACCTACAATACCAAGTAGTAAACAACTGATTAAAAATTTACGAAAAAACGATGTTTTACCTTTTGGTTTTGTTTTTTTAGAAGCTGGCTGTTTTTTCTTTTGAACTTGTCGTCGCTCCTCTCGAGAACGATAATTTTCTGACATGTTACTTTCTCCTGCCTTTCAATTCTCCCGTTGATTTACTTGAAAATATTGAGGTCACTTTCCCAAATACATTTAATCAAGAAAGTATATTGACCTGGAGCATTCAATATTTTCCCAATTCACAGATTATACATTTTAGAATACTTCTTATACAAACTATTTTCACTTCTATTTTTTCTAATAATACTGCCCCTTAAAGCATAGAATGTAAGAAGTGAATTTTTAATACCTCGTATAAATAATATACCTTTTTTTCAAATGGTCAATATTTTCTTATTTATAAATCAAAGGTGAAATAAAAATAGCACAACGATATGTACTTCGTGTGAACTTCCTTATAATTACGTATAACAAACATTTAATATATTGCATATAAGTATAATACTCCTTTAATTATTAGGATTTCAACACGACAATCCCCTTCTCTACAAGAAACCATCTAAAATGAAAAATAAGGAGTTGCGTAATGATGGAGCTATCTCCCGTTATTTCAAAAAAATTAGTTGCTGTTGGCTATAATCCTTTTTCTATGATTTTACGTATTCAACTAAAGAATGGTATGTATGATTTCTTTAATGTGCCAGAAAGCATTTACACCGGTTTATTAAACGCACATTCTAAAAGTTATTATCATAATACTTATATTAAAAATTCTTACCGCTATACTAAAATTTAAACTTGATTGGCATACAAAAAAGAAAGGCGAATCAAATCCCCTTTCTTTTTTGTATGTCAATCGCAATTTACCTTCTATTTCTTTTATTAATTTCATCATACGCCTGAACTTGTTTTTTAAGTCGCCTGTCGGCTTTTTTATCATGTACGACAAGAACTGCGTGTATCGCTCCTGGAACCCAAAAAATTAAGGTTAAAATGAAATTAATAATCGCTTGAAACGGCTTTCCGCAAAATAAAACAGCTACCGGCGGAAGTAGAATTGCTAATAAGTACATCATGTCTGAAAAACTCCTTAATGTTTATTTTTCGATTCTTCCCCATCCATCTCCTACACTATCAAACCTATGAAATCATGTTATTTCTAAAAGTGTATATAAGAACTCATCATTACAAAAATCACATATAATAGTATAACTAAATGAGGAACCTCTCACTAACGTTAACAAGTTATTTTCACCTGTTCGTTTATATGTATATTCTACGCCTATATGAAAAAGCCTACAAAAACAATTAACACATCCATCTTGTCCTACTTCTAAAATTGAAATACTCCAAACTTCATTGAAATGAGTATTTCATCACCTTTTCTTAGATTCCAATCGTTGTTCCTCTACTATTTCGGTTAATCCAATTGCTGAAATTACAGTACCTATTGCCTGTATCCAAATACCTATTAGCCCTATTATACGTTGATCTTCTTTATCTATATTACTGTCTTCTTTTCCCTTTTCTTCTTTTGGTATATTTTTAATACCTTCATATGCTTGTAATCCCGCACCTAAACTTTGCATTGAATTCCCTAATACGATAATCCACTGTATTCCATTTATCTCATTCAATGCTACTTCTACTCCTAAAAAAGCGCCAATTGATTGCAAACTATTTCCAGTAATTATAAGGAAATCATTTTCTTTCATTTGTTCATTGAGATTAAAATACGTTCCTATTACATTTGAAATATTACCTAAAGCTAATAACTCAATCCCCGTTTTCGCTAGCGCTTTATTTTTATTATCTATAGTTACCTCTTGCTTCTCACATTTATCTTCATCTTTCGCATCATTAGTTGCTATAATTTGTAATATATATCCGAGAGCTTGTAATGAACTCCCTACAATAACGAGATCCGACTCAATCTTTTCTTCCCCTGCAAACCCTCTAGTTGTTCCAATTGCTGCTATAAGATTTCCTCCTACTTGAAACCAGGCACCTGTCAATTCTAAATCGCGTAGGTTCATTTCCCATCACCTATATTTAAATTTTCTAGTACATTCAAAACAAACAAATATCACCTTTAATTCATTATTCTATTTTTCATATGTAATTTTGTGCATCACATAATGTACTAATAATACAAAAGAGCACCTTTCAGGCGCTCTTTTTGACAAGGAGTTTCTCAATGAATGTATGCCGGACATGTCAATGACTCACCGTTTTTATCTATTGATATATTTAATATATAATGAATTGCTTTATGTGACCACATTTCAGGTGTAGGAGATTCTTTTACATATTGAGGTGCACATAAGTGAAGCATTGGAGTGCTAATACTGCCACCTGGATCTAAAGCAACTACTGCCATACCATTTGGCAGTTCCATTGCCATTGACTGCGTGATACCTTCAACAGCAAACTTCGAGGCACAATATGGCGCAAGTTCAGCCTCGCCTTCTCTTCCCCAACTAGAGCTCATGTTAATAATAATTCCTTCTTTCCTAGCTATCATCGCCGGGACGAACGCCCTAATGACATTTACTACCCCGTTCACATTTACACTCATTACACTTTCAAATTCTTGTGCGGTAACTTTCCATAGAGGTGCATTTTGATTAACAATCGATGCATTATTTATTAACATATCGGGAGCCCTATACTTATTAAGAATACGACTTGCCCATTTACTAACTTGGTGATGATTTGAAACATCAATTATTTGAAAATCATGTGAAGCACCGTAATATTTATTAAGTTCTTCAATTTTATTTTTTGAGCGTCCACACCCTGCTATGTTCCACCCCAATTCATGAAACCTATCAACCATTGCACGTCCTAACCCTTGCGTTACTCCAGTAATAATTACAAGTTTCCCAATGTCGTTTCGCTCCAACTTCATCTCCTCCTTTCCATTAATATTACTCTTTTTATTCTTATTCAACTTCTCACTTAAGTATCAATTCATTTCATACTTTAGAAGTATTTTTGATATTACATATTACAAACAAAAAGAGTAACCATCATAGTTACTCTTTTTGTTTGTATCATTATTATTTTTAAATTGTATCTTCTATTCCCTACATTTCTCACATCGATAAATATAGGTTACACCTTAATGAAAGTATATTTATGTTTACGGTTCGATTTATCCAAATACTTTTCAATCCACTTTTTCAACTTAACAGAGCCCACCTCTATCAATAAATTTCCACCTAGTCTTATAACATACTTTTATTTAAATTCTCAATCTCATTTTGCAACTTTTTAAAATTCAGCTCTTCATTAATTTTAACATACTTTTTGCTCGATTGATTAAACAAAGCTTCAAACATTTTTCTATTCCGGAATATTTGTCAAATGAACCAATTAGACTATACCTTCATATAGTAATGCAAACAATTACTTATAAAGCAGGTGAAAATTATGCCCTCAGTTGTTGGGAATTTAGTTGTACAAAATAGTAACGGATCTTTCAACTTAGGTGATTTCTACAATGTTTCTCCAAAAGAGAATACGAAAGCTTATAACGGCTCTGGCGCATCTAACGTTGGTTTCGTAGTGAACACTTTTAGTGGGGTTAGCGCGACTAATACATTTGATTCTGATCTAGCAGATCAAAACCAAGTTGGTACGGCCTAACCAGATCTGTAATCATTTTTGTATAACATTTTAAAATTTGTCTATACTATACTCAGGCTGATACACAGCTATCATTGATTTTTTGAGTGCCAATCTTTTTCTCCCTTTCCCTGGGACTAAGCAGCTAGCTTGCAGCTAGCTGCTTTTTCATTTAGTTCTTCACCTCTTCAAAAAATTAGGTTTTAACAGGTAGCCTGACTCACAGCCTAATTTTGAGGTGTGAATCTGCCTGTCCGTAAATAGCTAGATAAATTAAAGAAGCTAAACTTCAAAATTCAGCTTCTTTTAGGTTACATCAATTATGTCCATTGCAGAAAATATATATGTTTTATAAAATGCATCTGTACATTTTACAATTTGTTGAATTGGATTTATATGAACCACTGTCATATAACTCGTAAGTATGTATCCTTCTTCAAAATATATCACTAACATCTCTTCTTCAGACAATAATGAAGTTAATAATTTGTCTGAAATGCTGTCTTTCGCTTCATTTGTTATTAGCGGTCTTTGGACTTTTAATTTCTCTCCAATAATTTTTTTCATACTTAATAATTGTTCCGACATTACTGTAAACGGAACCCACTCTCTTCCTTTTTCCTGTATCTTTACATAATTCATTTTCTTTACTCCTCAATTTTCTATATCTATCCATTCTTGAACTACCCCACTTTCACTTCGTTTAGAAGTGGGGGATTCCTAAGTAAAGAGTTCTATCGAACTCTAATTTATTAGGCTATCTCCGCAGCCCTTGCGGTTAGAAGCCTTATCGCTTCATTCTTTATCCATCTCTTATTTATACGTAGCGTAGCTTTCCAATTCAAAACTATTTATGAATTTGTAGACATCTCCACTTCAAAAGAACATTCGTTCTAATTATACACGAACGAACGTTCTTACGGAAGTGCAACATGTAAATTTTTCAAACAAAATGCAACTTTAATATATGAAGTTTATTCATACTCATTTATTACTCCCTTTTATTAATCAAATTTCTTTGCACTTCCTATCGCATCATAGAATACGTGTAGCAACAATAAAAGCGACTCCACCTAATGTGAAGTCGCTTTTATTGAACTAATTATATTTCTAATTTTACTTTTCTATCCTAACTAACGTTCTTTCTGTAATACAAATTTCAGCTACATCTCATTAACCATCCTTCAACAAAAGCATACACTTTTATTATGAACGAACTCACAAAGCTTTAGAAACTTATGATGTAAAACAATTCATTCCTCATAAGTTTCATACATATCGACAATTACTACCATTTATCCTGCTATTTGCAGGCAGTAAGATTCACACTCATCAATTTTTCACTTTCTTTATTGAATATGCTTGGGTTGCATTATAATATGTAATTCTCTCTCTGTTTCTGTTTTTTTCGGATTCCGATAATATTCCAGTTTATATTCTAATACTTCATACTCAACCATCCCAATCTTTATCCCTTTTGTTTCTTTTAATACAGCTAATAGAACGCTTATATTTTCATTAGATGATTCAAAAATTTTCCCTCCGCCTTCTCTCTTAAAAATAACTTTCATATATTCTCCCCAAAATTAATTTAATAATCTAGTAAATATAAAAATATTCATCCTATTTTAATAAAGTGAAGGCTAATAATCAGTGGGGGTTTTACGAGCAGTAAGACTCCCACAAATAGCGGGATAAATAATTCTTATCATCATTAAGAACATCTTTTTGTACTAAATGTTCAACATGTCACTTCCTATAAAGTTAATTTATACTCCAATAAATATGATATGTACCATTCTTTAAATTATGTCCTCAATTCACTCTCCAAGAAAATATATTTAGTTTATATTTAACAAAATTAATTAACTAAAACATTATCATTTCAACATTTTGCGAATTTAATTGCTTATTCCTTTTATCTACATCCAAATTTTCCTATTGTAATTCTTAATATTTAAATGTAATATTGTATTGTCTTACTATCTATTTATAACTCACACACTAACGCGAAAACAAAAAAAACAGAAATATAGCATTATGCTAAATCTCTGTTTTTCTTCTAAACCTTATTTCTCATCTAAGAATTTAAATGTATCTTTAAATTCTTTATCTGTTACTTTAATATCTGCTTCTTTCAATAGATCATTGATTACTTGTTGTTTCCATTTACCTGTCGCATCTTGCAGTCTTTGTTGTTCTAAATCTTTTCGAATCGTATCTTTTACTTCATCAAATGGTTTCAATTCTTTTTTATCCGTCACTTTTATTATATGATAACCATAAGATGTTTTTATTGGCTCACTTACTTGTCCTGCATCTAATTTATACGCAGCTTCCTCAAACTCTTTCACAGTTTGACCAGGAGCAAAACCAGCGATTTCTCCGCCCTGTTCCTTTGAACCAGTATCTTCCGAATACTGTTTCGCTAAAGCAGTAAAATCTTCACCATTATTTATTTTCTCTTTTACTTCTTTCGCAGTTTTTTCATCTTTCACTAAAATGTGACTTACCTTCATTTCAGGTTTATGGTTATCTTTCACATCTTTATCTGTGACAGTCGCTCTAATCGCTTTCTCAAGTGCAATTTCTGGCTTCATTCTCTCTTTTAATTCATCTTCATTCTTTAATCCTACTTGCTCTAAAGCGACTTTAAACTTGTCACCCATTTGTTCCTTCGCTGCTTCTACTTGTTTTTTAGCTTCTTCATCTGAAACTTTATATTTATCTAGCAATGCCTTATTTAACATCATTTGAGATAAAGTACTTTTTCCATATGTTTGCCTTAATTCTTTACTTAACTCTTTCTCTGTCACGTTTCCTACTTTTGATGTTGCAACATTTTCTGAGGAACCACACGCAGACAATGTTAGCGCCACACATGCAATAATAGTTCCCATAAATAGCTTTTTCTTTTTCAATTCAAATACCTCACTTTGATAAATGTATATTAGGAACTATACAGCGCTATTGTGAAATCAATGTGTTTTCTGCAAGTATTTCTCTTCATGCCAGAGACAAGCTTTATTAAATAAAAAAGCCGGCATAAATCCGACTTTTAACATCATTTAATCTGCACATGTTCTTCTTTGATCCATTTGTTCCCACCTATATCTATATATCCATCTTGACGATTCCAAATACGATAAGGAACCCTCCCATCGACCGCACCTGTATCATTCCCGTTTGGCCCATCGTACGTTCTAATTTCATATCCAGGTGTATACTTTGAATATGCATAAAACCATTGTACATTAAAATGTTCTAACTTAGCCCACTGTTGTTCACCACCTAAACAAATCATATCTTTTTCGCCACCTCCCCAATAACCTTTATAGATTAAATATGGGATTTTTTTCGTAAGTCTTCCTATAAATTGTGGATTCGCAGGATTTTCATATAAATTAATTCCGTATCCATCATCATATTTTGAAACTGCAATACCAATTCCATTTGGTCGCTTACTGTCTCCAATACTAGATTGATTTGTTTGATTTGAACCTATAAACCAAGAAAGATTTTTATTCCCAATTAATTGATTCAAATCACATTTTCCAATACCAGGAACATTTCCTGAATCAGTATATTGCCAAATATCACAAGGATATGCTGGTTTATTCCCTCCATAACGAGGAATCCAAATAAAATCAGCATCAATATTGCGAGCTCCAAATGATACATACGTGTGATGTCCTACATATAAACCAATTTTTTTTGCACCTAATCGGCGTAATTCATCAATAAATGCTTGAGTCCCGCCTTGCATATCTATCATTGTTTGAACTTCTACATCTGCCACCCAAAATTTAGCGTTTTTATCGCCACGATTCCAAAAATCTTGTGCTTCTTTTTTTGCATCTGAAATAGATATAAAACGGCAAAATGCATAATTCCCAAATGGGATACTACGTTTCTTCATTTCTTTCACATAACCTTGATACATAAAATCGATCGTATTCGAACCATCTTGAACTCTAGCAATAACTAAATCTAGCTGAGACGCTGCAATATCCCAATTAATATTTCCATTCCATTTCGAAATATCTACAATATAACCCATTACTAATCAACTCCTTTTTATTATCTTATTCAAAGCTTGTTTTATTGCTAGACCCATACGCCTAATAGCAAGCTTCTATAAGACAAATAAATATATTTTCATCATTTTTTAAAACTAAATAATTTCTTTTTATCCATAATAAATAAGTCCTTCTTTTTTTGCATTTGTAAACGATAAACTTGCGTTTATTTCATACTAAATATTGGAATAAAACTATAAATAATGTACATACTACATATAAGCAATTTTTGCTTATACTCATGAATGACCTCCAAGATTTTTCAATCTCCCTGTAAAAAGGCAGCTAAAAAAAGCTGCCTTTTTACAATTTATTATATAGAGACAAGTTAATTAACGCTTATTCCCTCATATTAGTCTGTTTTTAAGCTTTTTATAAACATGATATATATTTTTTCACAACACTATTTTGATACGTAATAGAAATTACATCAACTCATACAGTATATGTAATAATCAACTACAATAAAAATTACATATTATATTAATATGTCTTCCTAATTAAAAGGAAATAAACATATAACCTCTGTTATGTAAGGAGTTTATTTAATGAAAAAAATCCCTATCGTATTCAAAGTTCCCCCGAATTCAAAGCTAAAAGTTACATTCTATGGTCCTTGTAACGAAGTAATTACAAATGTATCTTTAATTAATCAACTACTCACCACTACCTGCCAAACTGTATCTCAATATCCAGACTTCAAGAAATATATAACTGAAGTCCGATCATTATCAAATTGTTAATCGTATAATTTTATGATTTATCATTTCGAATAGTACGATAACAAAATAATAAAAAGAGCCGCATCTTTCAAAAGAAACGGCTCTTTTTCATTTCACAAAACATGACTTCATTAAAAAACTAAAATAACTCATTAATTGATATTCTGTTGATATTTTATTGATATTTTACACATATTAATGAAATGCGCATATATTATCGTATGGAGATTCTCCACTCATAAAACCTATCTTTTTTTGAGCATACTTTATTTGTATGCTCCTTTTTTATTCTTTACTTAACGGCTTACCCTGTTAATATTTCCAAATATCATCTGAACGAACATTGAATATTTCAATCTTTTCTTATTATGTGCTATGAATATAAGTTTAATAATTTATCTGTAGCTACATTTTCAGTATCACTTAAATCGACAAAATAATGAAGTTGCCACAATTGACTCTTCTTAGCTTGATTACTAATAGGTTTATCCCAAATAGGGTAAACCCTCATAGCCATTTTCCCTTTTTGATTTTGAGTTTTTAATATTTTTTCTTTTAGAAGAATCTCTTTTGGAAAAATAAATTGTCCTAGGTTATTATCCGCTATACAAGTGATAACTAAAAGGTTCGGAGCTGAATCATAAGAAAATGCCTGATTGCTCATGGAGGCATTCTTCTCCCAAAAAGAAACAAATTGTCCAATCTTATTAGGCGTAATTTTTGATACCCTAAATCGGATGCTTCTATTATTTAGCTGGAATACCCCTCCTGCATATTCTGAATTTTGCTTTTCTTCTTTTCGTTTAGTAATTAATAGATTATTAGGTTTGTAAATCATTTCATCTAGTTTTTCAATTATATTACTAAAATTTGTCATGTAAACGCACCTTTTTTATTTTCCAGTATACCAAGAACGTTCGTTCTTGTATATTAAACTTAAACAAATGTTGGCTTTGAATAGTCTTTCAAAGATTATTTTATCTACTCCATCCATAACTTCAAATTTACTTTTATAGTATTTATTACATTACTCTTCCAATTCCTTATATTCTTCATTATTTCATTAATATATTAATAAAAAACGAGGTACATATTACATGAATCCATCCAAAATTGACTTCGGCTCCATAGAGCAACCTTTATTCCTATTAATTTTATATCTTATCGCAATTCTTTTAACACTCGGCATTACATTTAGTATATGTCATTCCCTTTTACTAAATTTAAATGCACCGAGATGGGTAGCAAAACTGTTAGCTATCATATTAACTCTAGGTGTTGCTTATCAAGTGTTTATGAACTTATTTTAATATATTACCAATTTAACACCTTTAACTAAAAGGCCCTACCATAAGGTAGAGCCTTTTTCAAAAAAATAGTCCATAAATCACAAACATGTCTTTTATTTTATTGGAGATGGGAATCTTGCAGCTTCAAAATGCGTACTAATAAATCCTGGATCATTTTGTATAATCAGTCCATCTACATCACTCTCAGCAAAAATTTCAACTACATCTCCTGCATGTAATTGAAGTATTGTTGAAACAGCTACGACATTTGCAAAATTGGGTGGACCAAAAAAGTCATTATCTATCGCTATAGCTGGATTATCATTTACCCGAATTTCTACACGCGCTCTATAATTCGTATTACTATCATTAGGTGCAAAGCTGATTGTACCAATAATAGAATAAACCCCTCTAGTCTTCGGAATAAAATCTGATGTTACTGGATTATATTCATTCGCTAAATCAAACTGTTCATTTTGGAATAATACTTTAACAAAAGTATTTGCAGTGACATTTTGATTTACTGTACTAACCGCTCTAAAAGCAGATGCCCTTACAAGTTTATCTTTCTCATTATCACAACACTTATCGTAATAATCTGTACTCTTCTTACAACAAGTATGCTTTGTCTTTTTATAGCCATTGCAATGCTTACAATAATAATAAGC
+>9_2#NODE_9_length_39996_cov_63.0617_ID_17
+GCGGGATGCGCCTGGGCGTGCCGTTGCGCGAGCAGGAGTTGCGCGGGGCGCTGTGGCGCTTGCTCGAGGACCCGGCCATGGCGGCGGCCTGTCGGCGTTTCATGGAATTGTCACAACCGCACAGTATCGCTTGCGGTAAAGCGGCCCAGGTGGTCGAACGTTGTCATAGGGAGGGGGATGCGCGATGGCTGAAGGCTGCGTCCTGAACGGTGCTGGCATAACAGATAGGGTTGCCATGATTTTGCCGTATCGGCAAGGCTGCGCGCTTGACAGCGTCATACCCCGGGCCAATTCTGCTGTGATGCATTTTATCGATCAGGGCTTACTGCAATGAGGAATGACGGAGGCTTTTTGCTGTGGTGGGACGGTTTGCGTAGCGAGATGCAGCCGATCCACGACAGCCAGGGCGTGTTCGCCGTCCTGGAAAAGGAAGTGCGGCGCCTGGGCTTCGATTACTACGCCTATGGCGTGCGCCATACGATTCCCTTCACCCGGCCGAAGACCGAGGTCCATGGCACCTATCCCAAGGCCTGGCTGGAGCGATACCAGATGCAGAACTACGGGGCCGTGGATCCGGCGATCCTCAACGGCCTGCGCTCCTCGGAAATGGTGGTCTGGAGCGACAGCCTGTTCGACCAGAGCCGGATGCTCTGGAACGAGGCTCGCGATTGGGGCCTCTGTGTCGGCGCGACCCTGCCGATCCGCGCGCCGAACAATTTGCTCAGCGTGCTTTCCGTGGCGCGCGACCAGCAGAACATCTCCAGCTTCGAGCGCGAGGAAATACGCCTGCGGCTGCGTTGCATGATCGAGTTGCTGACCCAGAAGCTGACCGACCTGGAGCATCCGATGCTGATGTCCAACCCGGTCTGCCTGAGCCATCGCGAACGCGAGATCCTGCAATGGACCGCCGACGGCAAGAGCTCCGGGGAAATCGCCATCATCCTGAGCATTTCCGAGAGCACGGTGAACTTCCACCACAAGAACATCCAGAAGAAGTTCGACGCGCCGAACAAGACGCTGGCTGCCGCCTACGCCGCGGCGCTGGGCCTCATCTGATGCTTAGGGCGCGCCGGCTGGCGCGCCCTACCAGATCTGGCAGGTTGCCTGCCGTTCATCCTCCTTTAGTCTTCCCCCTCATGTGTGTGCTGGTATGTCCTCCGACTGAGAGGGCCCAGGAGTATCAGGGTAGGGATGCCGCCTTTTTTTCTCGGCCGGCACGACACGGGGACTTGGTCATGATCGAATTGCTCTCTGAATCGCTGGAAGGGCTTTCCGCCGCCATGATCGCCGAGCTGGGACGCTACCGGCATCAGGTCTTCATCGAGAAGCTGGGCTGGGACGTGGTCTCCACCTCCAGGGTCCGCGACCAGGAGTTCGACCAGTTCGACCATCCGCAAACCCGCTACATCGTCGCCATGGGCCGCCAGGGTATCTGCGGTTGTGCCCGCCTGTTGCCGACGACCGACGCCTACCTGCTCAAGGAAGTCTTCGCCTACCTGTGCAGCGAAACCCCGCCCAGCGATCCGTCGGTATGGGAGCTTTCGCGCTACGCCGCCAGCGCGGCGGACGATCCGCAACTGGCGATGAAGATATTCTGGTCCAGCCTGCAATGCGCCTGGTACCTGGGCGCCAGTTCGGTGGTGGCGGTGACCACCACGGCCATGGAGCGCTATTTCGTTCGCAACGGCGTGATCCTCCAGCGCCTCGGCCCGCCGCAGAAGGTCAAGGGCGAGACGCTGGTCGCGATCAGCTTCCCGGCCTACCAGGAGCGCGGCCTGGAGATGCTGCTGCGCTACCACCCGGAATGGCTGCAGGGCGTACCGCTGTCGATGGCGGTGTGAGGTCGTCAGCCATTTCGCGCACTTTTTTCCGCTTCTCCTGCCGCATGCTCGGCCCGCGCCCCGGCGTCATCGGGCGTTCCCCTGCATTCCGGGATTTGGCCGCGGCTGCCGACTTGCGTAGTCTCTCTGCGGTCCGCCATCCCGAGGAGTCGCCATGCCGAAGTCATTCCGCCATCTCGTCCAGGCCCTGGCCTGCCTTGCGCTGCTGGCCAGCGCCAGCCTCCAGGCGCAGGAGAGCCGCCTCGACCGCATCCTCGAAAGCGGCGTGCTGCGCGTCGCCACCACTGGCGACTACAAGCCCTTCAGCTACCGCACGGAAGAGGGCGGTTACGCCGGTTTCGACGTGGACATGGCGCAGCGCCTGGCCGAGAGCCTGGGGGCCAAGCTGGTAGTGGTGCCGACCAGTTGGCCGAACCTGATGCGCGATTTCGCCGACGACCGCTTCGACATCGCCATGAGCGGCATCTCGATCAACCTGGAGCGCCAGCGCCAGGCGTATTTCTCGATTCCCTACCTGCGCGACGGCAAGACGCCGATCACCCTCTGTAGCGAAGAAGCGCGTTTCCAGACCCTGGAGCAGATCGACCAGCCGGGCGTGACGGCCATCGTCAACCCCGGCGGCACCAACGAGAAGTTCGCCCGGGCGAACCTGAAGAAGGCCCGGATCCTGGTGCATCCGGACAACGTGACGATCTTCCAGCAGATCGTCGACGGCAAGGCCGACCTGATGATGACCGACGCCATCGAGGCCCGCCTGCAGTCGCGTCTGCACCCGGAACTCTGCGCCGTGCATCCGCAGCAACCCTTCGACTTCGCCGAGAAGGCCTACCTGCTGCCGCGCGACGAGGCCTTCAAGCGCTACGTCGACCAGTGGCTGCACATCGCCGAGCAGAGCGGCTTGTTGCGCCAGCGCATGGAGCACTGGCTCGAATACCGCTGGCCCACCGCGCACGGCAAGTAATACAGGGCCGGCGAGGGTGGCCGCGGGCCCGCGCGGCCTTCCTTGGCGGCGGCAAAAACGTTATGGTCGGCGCCCCATCCTGGTGCCTGGTCCATGCGTTATCTACTGTTCGTCACCGTCCTCTGGGCGTTCTCCTTCAACCTGATCGGCGAGTACCTCGCCGGCCAGGTCGACAGCTACTTCGCCGTGCTTACCCGGGTCCTTCTCGCTGGCCTGGTGTTTCTCCCGCTGACCCGCTGGCGCGGCGTCGAACCGCGTTTCGTCGGCGGGGTGATGCTGGTCGGCGCGCTGCAGTTCGGCATCACCTACGTCTGCCTGTACCTGAGCTTCAACGTGCTGACGGTGCCCGAGGTGCTGCTGTTCACCGTGCTGACGCCGGTCCACGTGGCCCTGTTCGACGACCTGCTCAACCGCCGCTTCAACTTCTGGGCCCTGGCCGCCGCGCTGGTGGCGGTGCTGGGCGCGGCGATCATCCGCTACGACGGGATCACCGGCGAGTTCCTCCAGGGCTTCCTGCTGCTGCAACTGGCCAACGCCACCTTCGCCGCCGGCCAGGTGCTGTACAAGCGCCTGGTGCGCAAGTACCCGTCCGAGCTGCCGCAGCGCCAGCGCTTCGGTTATTTCTTCGTTGGCGCGCTGCTGGTGGCGTTGCCTGCCTGGCTGCTGTTCGGCGATCCGCAGCGCCTGCCGGCCGGCGAGCTGCAATGGGGCGTACTGGTATGGATGGGGCTGCTGGCCACCGCCCTCGGCCAGTTCTGGTGGAACAAGGGCGCCACCGAGGTGGACGCCGGTACCCTGGCGGTGATGAACAACCTGCACGTGCCGGTCGGGTTGCTGCTCAACCTGCTGATCTGGAACCAGCACGCCGACCTGCCGCGCCTGGCCCTGGGCGGCGCGGTGATCGTCGCTTCGCTGTGGGTCAACCGGCTCGGCCGGCGCGAGGTGCGTGCATGAGGATTTCCGGACAGGGCGTGCTGCTGTCGCTGGCCGCCTCGGTGCTGTTCGTTACCCTGCCGGGCTACGTCCACCTGCTGGAGCCGCTGGACAGCCTGCAGGTGGTGGCGCATCGGGTGGTCTGGTCGATCCCGATGGTATTCCTGCTGGTCGTCGCCACCCGCCAGTGGCCGACCCTGCGCGCTGCCTGGCGCCGGCTGTTCGCCGAGCCCTGGCTGCTGGCCTGCTTCCCGCTGACCGCGGCGATGATGCTGCTGCAATGGGGCATCTTCATCTGGGCGCCGTTGGCCGGGAAAACCCTTGAACTGTCGCTGGGCTACTTCCTCCTGCCGCTGGCGATGGTGCTGGTGGGGCGGGTGTTCTACGGCGAGCGCCTGACGCCGCTGCAGGCTATCGCCGTGGCCTGCGCGCTGGCCGGGGTGCTCCACGAGTTCTGGCTGACCCGCGCGTTCTCCTGGGTCTCCCTGGTCACCGCGCTGGGCTATCCCCCGTACTTCATGCTGCGGCGCAGGATGGGCGTGGACGCGCTGTCCGGGTTCGTCTTCGAGATGCTCTTCCTGCTGCCGCTGGCGTTGGCCGCGCTGTACTGGCTGGGCGACGAGAGCCAGGCCTTCCGCGAGGCGCCGCGCCTGTGGCTGCTGCTGCCGATGCTGGGGCTGATCAGCGCGCTGGCCTTCGGCGCGATGATGGCTTCCAGCCGGCTGCTGCCGATGGGGCTGTTCGGGATTCTCAGCTACGTCGAACCGGTGCTGCTGTTCCTGGTGGCGGTACTGTTCCTCGGCGAGGCGTTCCGTCCCGAGCAGCTATGGACCTACGCGCCGATCTGGCTGGCGGTGCTGTTGACCGGCTGGGACAGCGCGCGCCTGCTGAGGAAACAGGCGCGGCGGGGCATCTGAGCGAGCCGCAGGCGCCGGAATCAGCGCTTGCGGGTGCTTTCGACCTGGGCGAGGGTGGTCGGCAGGATGCGCTTGCCGGCCAGGTAGTGGCGTTTCCAGTAGCTGCTGTTGAGGTCGGAGACGCGGACCTTCTTGCCGCGCCGCGGCGCGTGCACGAAGCGGTCGTTGCCGACGTAGATGCCGACGTGGTCGACGCTGCGGCTGCGGATCCGGAAGAACACCAGGTCGCCCGGTTGCAGCTTGCCGCGGGAGACCTTGTTGTTGTCCATGTTGTAGATGGCGCGGGCGGTCCGCGGCAGGTCGACGTCATCGACGTCCTGGAACACATAGTTGACCAGGCCGCTGCAATCGAAGCCTTTCTTCGGCGTGGTGCCGCCCCAGCGGTAGGGGGTGCCGATCATGCTGAAGGCGCGGTCGGTGACTTCGGAAGCGGCGGCCGCGACCACCGAGCGGTTGGCGGACTGGCGGGTGCTGACGACCCGGCTGGGCGACAGGGTGGAATTCTTCGACGGCTTGAAGGTGTGGGTGACCTGGTTGGAAGCCAGGCTGGGCGTCGAGAGGGCGGCCAGAAGGGCCGCGAAGCCTACAGACAGGCATGTCAAAAAGGGTGAACGCATTTCGGCATGTCTTCGCGTGCGTGAATAACGGTCCAGGCTTCCGCTGGTTCGTGGTTACTCTCTGTTCATCGGAGTGTCTTCTGGGTGACCGGAACGAGCCCTCCTGACTCTTCCGACCAGGCCGTCAAACGAAACGGCCAACTGCTTCCGGGCCTGGATGCATTCAGGTTGTCCCGGCGATAACGGGCTTCACGAAGGAAAATCGGGGACTCATCGGCGTTCCCAGCGTATTCCCCTACGAAAGCGGCGGCTATTGTGACCTATTTTGACGCCGGCCTTCTGACCATTCGTCGAATGATCGGTTCCGGATGTGACGCGCCGGTTTCGCCGTGCAAGTGGCGATACTTGCGGGTCCGGCAATGACCTGTTGTTCGCCGTGGCCTTGGAAAGCCTCTGCGCCGGGGGTATGTTCGTGTTCCCCGTACCCGAGTGAAGCCCGTAGAAGCGAGTCCAGATATGACCGAAACAGCCAAGCGTCCCTTGTACGTTCCCCATGCCGGCCCATCGCTGCTGGAGATGCCGCTGCTGAACAAAGGCAGCGCGTTCAGTACCCAGGAACGCATCGATTTCAACCTGCAGGGCCTGCTGCCGCACAACATCGAGACCATCGAGGAGCAGACCGAGCGCGCCTACAGCCAGTACAACCTGTGCAACACCGATCTGGACCGCCACATCTTCCTGCGCTCGATCCAGGACAACAACGAGACCCTGTTCTTCCGCCTGCTCGAGGAGCACCTGGAAGAAATGATGCCGATCATCTACACCCCCACGGTCGGCCAGGCCTGCCAGGAGTTCTCGAAGATCTACCGGACCCACCGCGGCCTGTTCATCTCCTACCCGGACCGCGAGCGGATCGACGACATCCTGCGCAGCGCCACCAAGAACAACGTGAAGATCGTGGTGGTCACCGACAGCGAGCGGATCCTCGGCCTGGGCGACCAGGGCATCGGCGGGATGGGCATCCCGATCGGCAAGCTGTCCCTGTACACCGCCTGCGGCGGTATCAGCCCGGCCTACACCCTGCCGGTGGTGCTGGACGTAGGCACCAACAACCCGGACCTGCTCAACGACCCGATGTACATGGGCTGGCGCCACGAGCGGGTGAGCGGGGCGCAGTACGAGGAGTTCGTCGACCTGTTCATCCAGGCGATCAAGCGCCGCTGGCCCAACGTCCTGCTGCAATTCGAGGACTTCGCCCAGACCAATGCCATGCCGTTGCTGGAGCGCTACAAGGACGAGCTGTGCTGCTTCAACGACGACATCCAGGGCACCGCCGCGGTGGCCGTGGGCACCCTGCTGGCGGCTTGCAAGGCCAAGGGCGAGAAGCTCAGCGAGCAGACCGTGACCTTCGTCGGCGCCGGCTCCGCCGGTTGCGGCATCGCCGAACAGATCATCGCCGCCATGCAACTGGAGGGCCTGGACGAGGCCCAGGCGCGTCGGCGCATCTTCATGGTCGACCGCTGGGGCCTGCTCACCGACGACATGAGCAACCTGCTCGACTTCCAGCACCGCCTGGCGCAGAAACGCGCCGATCTCGGTGCCTGGGGCGGCCAGCAGGGCGACGACCTGGCGTTGCTGGAAGTGATCCGCAATGCCCGGCCGACGGTGCTGATCGGCGTCTCCGGGCAGCGCGGGCTGTTTTCCGAAGAGGTCATCCGTGAGCTGCACAGCCATTGCAAGCAGCCGCTGGTGATGCCGCTGTCCAACCCGACCTCGCGGGTCGAGGCGACTCCGCAGGAAATCCTCAACTGGACCGACGGCCAGGCGCTGGTCGCCACCGGTAGCCCGTTCCAACCGGTGCAGGTGGGCGACAAGCGGATTCCCATCGCCCAGTGCAACAACGCCTATATCTTCCCCGGCATCGGCCTGGGGGTGATCGCCGCGCGGGCCAACCGGGTCACCGAAGGCATGCTGATGGCCGCGGCCAACGCCCTGGCCAACTGCTCGCCGATCGTTACCCAGGGCGAGGGCGCCGTGTTGCCGGCGCTGGGCGACATCCGCGAGGTCAGCAAGCGCATCGCCGTCGCCGTGGCCAAGCAGGCCCAGGCCGAGGGCAAGGCCCTGCATACCAGCGACGAGGTACTGAACGACGCCATCGAGGCGAACTTCTGGTTCCCGCGCTACCGTGCCTACCGCCGGACTTCGTTCTGAGGCTCAGCCGCAGGCTGCGCACGGGGGAGAGGCGTTAACCGCCGATATTCCGCGCGATCGGTGCGAGAACGCGAAAAGGCCACGAGGTGGCCTTTTTCGTTGACGGTAGCGCTAGCGCTAGCGCACATGATCGGGGCGCGTCCGGTGTTCGGCCTGGGTTTCCGGGTTTTCCGCCGCGCGCCGCGCCAGGGCCGGCAGGACATGATCGCGCAGCAGCGGCGCGAGATTGTCCGGCTGCGCTTGGCCGGGGACCAGCCAGGCCAGTTCCTCCAGCTCCGCCTGCGCACAGACGGCGTGGGGCAAGCGGGCGACGTAGATATCGGCATCGACGCGGGTGTTCGCCTCGTTGGCCGCCGGGGCCTGGAAGCTGCCGAGGTGCTCGAAGGTCGAGGCGCCCATCGGCAGGCGCAGTTCCTCCAGCAGTTCGCGCTGTAGCGCGGCGAGGGGCGTTTCGCCCGGCTCGCGCTTGCCGCCCGGGAGCATGAAGGCCTGGGTGCCGCGCTTGCGCACCAGCAACAGGTTGCCCTGGTCGTCGAACAGGCAGGCGGCGGAAATGCTCAGCAGGTTGTCGGTCATTGCGGGTCGTCCTCGGCGATCACCTGGTAGCGCATCTGTACGATGCCGCTGTTGTAGCCATGTTGTTCCAGCAGTTGCAGGCGCCGCTCGCGGCCGCCGGCGAACAGCGGGATGCCGGCGCCGAGCAGCTGCGGAATGACGCTGACGATCACCTCGTCGAGCAGCCCGGCCGCCAGGCAACTACCGGCGAGGCTGCCGCCGCCGGCCAGCCAGACCCGCCGGCAGCCCTGTTCGCCGAGGCGTGCGAGGCCTTCCTGGGGCGTGCCATGGCGCAACTCGACGCCTTCCACCGCGCTCTCCCGGGGATTGCGGGTGAGCACCTGGCAGGGCTTGCCCGGATACGGCCAGTCGCCGAAGCCGCGCACGATATCGTAGGTGCCGCGGCCCATCAGCAGCCCGTCGATGCCCTGGTAGAAGCCGTTGTAGCCATGGTCGTTGCCGCCCTCGGCGAAACGGTCGAGCCAGTCGACGCTACCGTCGGGACGGGCGATGAAGCCGTCCAGGCTGGTGGCGACGTAGTAGATCAGGTGCGGTTTCATGGACGGCGCTCCCCTCGCTTCAGACAGTGGCTTCGTCGCTGCGGCTCGGTGCGGCCAACGCCTCGAACGAACGGGCCTCGGCGTCACGCCCTTCGAGCATGCCCTGCAGTCCCTGGCGCAGGTCCTGGCCGCTGGGTTGCTGGTAGGCGCCGAGGCCGAACTCCGGCATCACCGCCAGCAGGTAGTCGAACACGTCGCCCTGGATGCGCTCGTAGTCGACCCAGGCGGTGGTGCGGGTGAAGCAGTATATCTCCAGCGGGATGCCCTGGGCGGTCGGCTGCAACTGGCGGACCATGCAGGTCATGTGCGGATGGATGTCCGGATGGTTCTGCAGGTAGGCGAGGGCGTAGGCGCGGAACGTACCGATGTTGGTCAGCCGGCGGCGGTTGGCGGCCAGCGGGGCGACCCCGCCGTTGGCGGCATTCCACTCCTGCAACTCGGTCTGCTTGCGGGCCATGTATTCGGTGAGCAGGCGCACCTGGCTCAGGCGCCGCTCTTCCTTCTCGTCGAGGAAACGCACCTGGCTGGAGTCGACGTAGATCGCCCGCTTGATCCGCCGTCCGCCGGACTGCTGCATGCCGCGCCAGTTCTTGAACGACTCCGACATCAGGCGCCAGGTCGGCACCGAGACGATGGTCTTGTCGAAGTTCTGCACCTTCACGGTGTACAGGGTGATGTCCACCACGTCGCCGTCGGCGCCGACCTGCGGCATCTCGATCCAGTCGCCGACTCGCAGCATGTCGTTGCTGGTGAGCTGCACGCTGGCGACGAAGGACATCAGGGTGTCCTTGTAGACCAGCAGGAGGACCGCCGACATCGCGCCGAGGCCGGACAGCAGCAGGAGCGGCGAGCGGTCGATGATGATCGAGACGATGATGATCGCGCCGAACACGAACACGGCGATCTTCGCCAGTTGCACGTAGCCCTTGATCGAGCGGGTGCGGGCGTGCTCGGTACGCGCGTAGATGTCCAGCAGGGCATTCAGCAGCGCGGTGAGGGCGAGGATCAGGAACAGCACGGTGAAGGCCAGTGCCAGGTTGCCGAGGAAGTGCGCGGCCTTGTCCGGCATCTCCGGGATCCATGGCAGGCCGAATTGCACCAGCAGCGAGGGCGTGGTCTGCGCCAGGCGCTGGAACACCTTGTTGCGGATCAGGTCGCCGAGCCAGTGCAGCGCGGGCTGGCGGGCGAGCAGGTTGGCGGCGTAGAGGACGATGTAGCGGGCCACCCGGCCGAGGATCAGGGCGCCCACCAGCAGCAGGCCGAAGGCCAGGCCGGCGTGCAGGATAGGGTGTTGGTCGAGCGCCGACCAGTACCCGGAGAGCTGGTCGAGAAGGGATGTGGAGTCCATGGACAGGCGACTTCCTTTGTTGCGGGCGGGGGGGACGGGCCGGCCCCGCGGTTGAACGGACATCCCGACGCGGGGGCCGGGAACGCACAAAGGAACCAAGAGTGCCCCATCGGGCGCCGGATCGCATCCCCGACGTGTCTACAAAGGTTTTCCGCCGACGCGCGGGCTCAGCCGGCAAGCTCCTCCAGGGTGCGCCCGCGGGTCTCGATGCCGAAGGCCCAGACCACCAGGGCGGCGACGCCGAAACAGAGGGCGCCGAGGGTGAACACCCCGCCCTGGCCGGTGAGCGGCAGGACCAGCCCGGTGACCAGCGGGCCGAGCAGCGAGCCGATCCGCCCGACCGCCGAGGCGAAGCCCGAGCCGGTGGCGCGCGCGGAGGTCGGATAGAGTTCCGGGGTATAGGTGTAGAGCACCGCCCACATGCCGAACAGGAAGAACTGCATGGCCAGGCCGAAGCCGATCAGCAGTGCCAGGCTGCCGCCGAACACCGCGGTCTGGCCGTAGGCGTAGGCCATCGCGCCGCCGCCGAGGAGCATCAGCACGCAGCTCGGCTTGCGGCCCCAGCTTTCCACCAGCCAGGCCGCGCAGAGGAAGCCGGGTATCCCGGCCAGCGAAATCAGCACCGTGTAGTACACCGACTGGGTGACGGCGAAGCCGGATTGCTGGAGCAGCGTGCTGAGCCAGGAGGTCAGGCCGTAGAAACCGAGCAGGGCGAAGAACCACAGGCCCCAGACGGTCAGGGTGCGGCGCCGGTAGGCTGGCGACCAGAGTTCGGCGAAGGCGCTGAAGAAGCCCGGACGGCTGCGTTCCCGCTGCGGCTGGCGCAGCGGCGGCGGCAGTTCGGACAGGCCCAGCGAACGCATCACCCGTGTTTCTATGTCGCGCAATACCCGGTCCGCCTGTTCGCGCCGGCCGGCCTGCTCCAGCCAGCGCGGCGACTCGGGAATCAGGAAGCGGATGGCGAGGACGAACACCGCCGGCAGCGCCAGCACCAGGAAAATGCTGCGCCAGCCGGTCAGCGGCAGCAGGAAGTAGGACAGGCAGCCGGCAGCGACGAAGCCCAGCGGCCAGAAGCCGTCCATCAGCGCAATGTACTTGCCGCGGCGGCTGGCCGGGATCATCTCCGACAGCAGCGACTGGGCGATGGGAAACTCCATCCCCATGCCGATCCCCAGCAATACCCGGTAGAAGGTCAGGCTGTCGAGGTCGCCGGCGGTGGAGCACAGGTAGCTGGCCAGGCCCCAGAGCACGATGCTGGCCTGGAATACCGGCTTGCGCCCGAAGCGGTCGGCGAGCATGCCCGACAGGGCCGCGCCGATCACCATGCCGAAGAAGCTCGAGCTGGCCAGCAGCCCGGCCTGCGCCGAGTCGAGCCCGAACTCGGCTTTGATCGAGCCGAGCAGGAAGGTCATCATCGCCAGGTCCATCGAGTCGAAGAAGAACGCCAGCGCGATGATCACGAAGACCAGTCGGTGATACGGACTCAGCGGCAGCCGTTCGAGGCGTTCGGCGGCGGATGCGGGCGCGTCGGGCATGACCTGGTTCCTCTGGGCGGCGGGCGTCGAACGAGTCTGCGATCGCCGCCCGCGCCGTGCTTGCCTGGCGGCGACCCGGCGTCGAGCCGATTGCGACGCCGGCGCTGGCCGTCGCGCCGCGCGAATAAAGCCTGCGCGCCGGCGCGGCAACCGTTAGGCTATGCACCTGTCCATTTTCACGTGCAATGCCGAGGTTTCCCTTGTTCAGCCAATTTCCCCTCCACGAACGCCTGCTGAAGGCACTGGAAAGCCTGTCCTTCAGCGAGCCGACGCCGGTCCAGGCCGCGGCCATTCCCAAGGCGCTGGAGGGGCACGACCTGCGGGTCACGGCGCAGACCGGCAGCGGCAAGACCGCGGCCTTCCTGCTGCCGCTGCTGCACCGCCTGCTGGCCGAGGACAAGCCGCGCTCCCTGGCGCGCGCGCTGATCCTCCTGCCGACCCGCGAGCTGGCCCAGCAGACCCTCAAGGAAGTCGAGCGCTTCGCCCAGTTCACCTTCATCAAGGCCTGCCTGATCACTGGCGGCGAGGACTTCAAGGTGCAGGGCGCGCGCCTGCGCAAGAACCCGGAGATCATCATCGGCACCCCCGGCCGCCTGCTCGAGCAGCGCAACGCCGGCAACCTGCCGTTGCAGGACATCGAGGTGCTGGTGCTGGACGAGGCCGACCGCATGCTCGACATGGGCTTCGCCGACGACGTGCTGGCCCTGGCCAATGCCTGCCCGGCCGAGCGCCAGACCCTGCTGTTCTCCGCCACCCACAGCGGCGCCGGGTTGAACAAGGTGATCGCCGAGGTGCTGCGCGAGCCGCAAGTGCTGCGCCTGAACCAGGTCGGCGAGCTGAACGAGAATGTCCGCCAGCAGGTCATCACCGCCGACGACGTGGCGCACAAGGAACAGTTGCTGCAATGGCTGCTGAGCAACGAGACCTACACCAAGGCCATCGTCTTCACCAATACCCGGGTCTCCGCCGATCGCCTGACCGGGCGGCTGATCGCCAACCAGCACAAGGTCTTCGTCCTGCATGGCGAGAAGGACCAGAAGGACCGCAAGCTGGCCATCGAGCGCCTGAAGCAGGGCGCGGTGAAGATCCTCGTCGCCACCGACGTCGCCGCACGCGGCCTGGACGTCGAAGGCCTGGACCTGGTGATCAACTTCGACATGCCGCGCAGCGGCGACGAGTACGTGCACCGCATCGGCCGGACCGGTCGCGCCGGCGCCGAGGGCCTGGCGATCTCGCTGATCTGCCATGGCGACTGGAACCTGATGTCGAGCGTCGAACGCTACCTCAAGCAGAACTTCGAACGACGCAACATCAAGGAACTGAAGGCCGCCTACCAGGGGCCGAAGAAACTCAAGGCGTCGGGCAAGGCCGCCGGCAGCAAGAAGAAAAAGCAGGACAGGAAGGGCGCCGCCGCCAAGCCCGCGGCCAAGCGCAAGCCCGCCGCGCGGCCGAAGGCCGGGCCGTCGGCGGTGGTCAGCGCCGACGGCATGGCGCCGCTCAAGCGCAAGAAGCCGACGGCGGAGTGATCGCGCGCCGCCGACCGCTTCGGAGGGCGGATAACCGTTTGCGGTTATCCGCCGCGCCGGCGTTGGATGGCGGATAACGCCGCTGGCGCTGTCCGCCCCGGGGGACTGCCTGGCCCCGTTCTCAGCTCCCCGCCGTCGCGCCCGCCTCGTCGTTGGCCGGCGGCGTGGCACTCTTCACCAGCGGCGTATCGTAGCTGCTCGCCTCGTAGCTCACGCAATGGCGGATCTGCGGCGGACCGTCGCCGGCATGCAGGGCGGTGACGTTGTCGATGACGATCTTGTCGGCCAGGGTCATGCGGTCGAGCATGCGCAGGTGCTGGATCCAGTTGTCCACCAGGAACAGTTCCTGCCAGACCTCCGGGTTGCTCACGTCGCGGAACAGCGACCAGCGCTCCGCGCCGTTGCGCAGGCGCAGGCGGCGCAGCGGCTGGGCGGCGCGAACGAAGTCGCGGGTGCGCTCGGCGGGAATCCGGTATTCGATGGAGACCAGCACCATGCCCCGCCGCGTGTTGAAGACGAAGCTCGGCTGCCCGGGCATGCTCGCCGGCGCGCGGGAAATACTGGCGGCGTCCATTTCCGGCAGGCGCGAGTTGTACAGGAGGATCACCGAGGCCAGCAGCAGGCAGCCGGCGGCCAGCAGCGCGCCGTGCACGGTCATGGTCTCGGCGAGATGGCCCCAGAGGAACGAACCCAGCGCCAGGCCACCGTACAGCGCGGTCTGGTACAGCGCCAGGGCGCGCGCCTTGATCCAGTCGGGGACGAGGATCTGCACCGCCGAGTTGTAGGTGGCGAGGGCGCCGATCCAGCAGCCGCCACCGAGGATCAGCACCGGGAACAGGACCCAGAGGTTGTCCACCAGGCCGAGGGTCAGCAGGATCAGCGCCAGGGTGAAGCCGGCCAGGCTGATCAGCCGGCTGCTGCCGATCCGCTGGCGCAGACGCGAGACCTGGGTGCTGCCGAGGATCGCGCCGAGGCCGAGGGCGCCGAGCATGTAGCCGTAGATCGCCGCGTCGCCGTCCGGGTTGCGGTGCGCCAGCAGCGGCAGCAGGGCCCAGACCGCGCTGGCGGAGAGGCCGAAGGCGAAGGAGCGCATCATCACCAGGCGGGTGACGGTTGAGTACTGGGTGAAGCGCAGCGCCGCGGTGACGCCTTCGAGGATGCCTTCCGGCGGCAGGCTGCGCTTGGGCACGTCGCGCCGCCACTGCCAGATCGCCCAGATCAGGGCCATGTAGCAGAAGCTGTTGAACAGGAACACCCAGGCCGGTCCCACCGCGCTCAGCAGCAGGCCGCCGAGGGCCGGGCCGGCGGCGCGGGCGACGTTGTAGTTGACGCTGTTGAGCAGCACCGCGTCGCTGACCATGCGCGCCGGCACCTGCTCGTTGACCGCCGCCTGCCAGGCCGGGATGGTCACCGAGCCGCCGAGGGAGATCCAGAGGATGGAGATGATCAGCAGCACCGGGTCGAGGTAGCCGAGGAAGGCCAGCAGGGTGGCGAACATCGCTCCGGTCATCTCGAAGCTGAGCCCCCAGAGCATGATCTTGCGCCGGTCGTGGTTGTCGGCGATGACCCCGGAGAGGATCGACAGCAGCACCAGCGGCAGTGCCGCGGCGACCTGGATCATCGCCACCATCAGCGGGCTGGCGTGGGCGTCGGTGACCACCCAGGCGGCGGCCACCGACTGGGCCCAGGTGCCGAGGTTGGCGAACAGGTTGCAGATCCAGATGATGCGGAAGGCCTGGATCGAGAACGGCGCCCAGGTGCCGGTGCGTTCTGGCTTGGCCGCTTGGCCTTCGGGTTTGAGGGGCAGGTCGTGCTTGGGCGAAACGGACTGGAGCATCAGATGGGTGCCTTGTATCAGCGTGCCTGATGTCGGGAAAGTCTAGCCGCCTGGCGCCTGGGCGCCATTGATGGCGGTCATGGGGCCGGCCCGGCGTGGATAGACATTGGTCCGATGGCGCTATCGGAGAGTTCCGATGTCCAGGCAGGACAGTGCCCTGGGTGTCCCGCATTGGTAGGCTTGCCGGCACCGAGTCGAGACAAGAGCGAAAAGCCGATGAAGTTGCTGTTGCGTTGCCTGCTGCTGGGGGCGTGGGTCGTCTCGCCGAGCCTGTGGGCCTGGTCCAACCATACGGTGGGCAGCTACCTGGCATTGCGCGAGCTGGCGGCCATCCGCGAGGCGCCGGAAGTCGAGGTGGAGCCGCTGGAGGCGTTCCTCGCCGCCGAGCGCGGCGGACTGGCCGCCCTGCTGGACGAGCAGGAAGCCTACGCCCGAGCGCATATCGGCAACTACCCGGCGCGTCCGGACGCCCTGCGCTTCGCTGCCGAGGGCGAGGCCGGCGACTTGCGTCAGGCGTTCCTCGCGGCGCTGCGGGTCAACCCGGAGATCCGCCTGGCGCTGGCGCTCCAGCCGCTTCCCGGGCAGGACCAGCCGCAGCGCCCGCACCTCAAGCCACAGGAGGTGCTGGTGTTCCAGAACCTCTCGCCGTGGACCGCCTGGCGTTTCATCCGCCTGGAGCCCGGCGAGCGAGTCGCGCCCCTGGCAGTGCTGGCCACCGCCGCCGACGAACCGGACTACGGCCACGACATCAACCTGTTCAGCGACAACCCCGGCGAAGCCGGCCAGCGCTACGGCTTCGGCACCCAGCCATTCGGCGACCCGCGCTTCGAGTTCAGCTCCCAGGCGCCGTTCCACATGGGCTTCTATCACGAGGCGGCGGTGATCTACAGCGGCGCGCCGTTCCTCGCCCGGGCCTGGCCGGAATGGCGTGCCTACCAGTACTTCGGCCTGTCCCGCTTCGCCTTCGCCAACGGTCATCCCTACTGGGGCTACCGGTTCCTTGGCTGGGGCATGCACTACATCCAGGACATCACCCAGCCCTACCACTCCACGCCGCTGCCCGGTGCCAGCCTGGCGGCGATGCTACAGATGGAGGGCAAGGCATTGCTCGGCTACCCGGAGGAAAAGCAGGCGGCCATCGAGCGTGTCGCGAACCGCCATACCGCGGTGGAGAAATACCAGTTCGACTGGCTGCGCCAACTGCTCCGCGACGGCCGCCCGCAGCCGATGCTCGACGCCTACGCCGACACCCGCCGCGACGGTGCCTATCCGGCCTATTCGCCGACCTACTTGCGCGAGGTGGTGGCCGCCGAGTCGAACGCCCACGCCGCGGCCTTCGACGCCGCCATCGGCGAATGGCTGGCCGCCCGCCCGGCCTCCGCCGCGCAGGACTTCAGCGAGAGCAACCAGCCACGCCCCGAGGCCCACGACAATGCGGGGCTGAACGCGCAACTGATCGAGCTGATCGGGCATTTCGGCGCGCATAGCCGGAACATCGTCAGGGCGGCGTTGGAGACGGAGGAGGGTGGGGCGAAGGAGTGAGGGGGCGGCGGATAAGCGGCGGATAACCGCGAGCGGTTATTCGCCCTACGGAGCGGGGGCACTGTCCGGCGTTTCCGGGGCGTGTAGGGCGAATAACGCCATGGGCGTTATCCGCCGATGTCGCGGATAAGCGGCGGATAACCGCGAGCGGTTATTCGCCCTACGGAGCGGGGACGCTGTCCGGCGTTTCCGGGGTGTGCAGGGCGAATAACGCCATGGGCGATATCCGCCGATGTCGCGGATGAGCGGCGGATGACCGCGAGCGGTTATTCGCCCTACGGAGCTGGGGCGCAGTCCGGCTTTTTCGGGGTGTGTAGGGCGAATAACGCCATGGGCGTTATCCGCCGATGTCGCGGATGAGCGGCGGATGACCGCGAGCGGCTATTCGCCCTGCGGAGCAGGGGCGCTGTCCGGCGTTTCCGGGGTGTGCAGGGCGGCGAACCCGCCCCGCCAGGCGGGTCGATGCCGCGACTCAGTCGCGCAACAGCTCCGCAGGCACCTCGCTGCGCAACATCAACTGGCACTGCTGGCTCTCCGGGTCGAACAGGATCACCGCCTCGCCCCGCCGCAAGGCATGCCGGGCGCGTTCTACACGCACGTCCAGCGGGGTCTCGTCGCCATTGTCGGTGCCTTCGCGGGTGACGAAGTCTTCCAGCAGGTTGTTCAGGGTGTCGGCTTCGAGCAGGTCGTGGGGGATCAGCATTGGCGGTACTCCGGGATGGCGGCGAATGCTAGCGCGACGCATCGCGCACTGTCATGCCTGTCGCGAAGGCTGGCCGAGCAGGCGTTCGAGGGTGGCATAGAGTTCCGCCCGGTCCACCGGCTTGCCGAGGTAGGCGTCCATGCCAGCCTCGATTCCGGCCCGGCGGTGTTCGTCGAGGATGTGCGCGGTCAGGGCGACGATCGGTACGCGTGGCCAGCCCTGGGCACGCTCCTCCCGGCGGATCAGGCGGGTCGCCTCGAAGCCGTCCATTTCCGGCATCTCGCCATCCATCAGGATCAACTGGATGCCGTTCGGATCGCGCAGGTACTCGTCCAGCGCGAGCCGTCCGTTGCCGGCCAGGCGCACCGCGTAGCCGCGCTTGGCGAGGAAGCCGCGCACCACCAGCTGGTTCACCGGGTTGTCCTCGGCGACCAGGATGCATGGGGCGTCCAGGCGTTCGTCCGGGGCCGCCTCGCTGCTCCGCCCTGGCTGTCGGCGCCGCTCCCGGTACAGTTCCAGCAGGGCTTCGCGCAGGGCCTTCACCGCCACCGGCTGGGCCAGGGCCAGCAGGCGCAGGCCTTCGTGCGGCGGCAGGTCCTGGCAGTGCTGCGGCGGGCATAGCAGGAGGATGCGCTGGCCTTGCTCCAGTTGCGCATAGAGGGTGTCCAGCCAGATCGACGGCGGCCCCGGCCAGGGCGCCGCCAGGACCAGCAGGGGCGGTGCGCTGAAGTCCTCCAGGTAGGCGTTCAGCCGTCTCGGCTGCAGGCAGCGTTCGACCCGCAGCCCCCAACGCTCCAGCAATGCCTGCAGGCAGTCCAGGGTCAGGTTGTCCTCGCTGGCCAGCAGGGCCGGGCGGTGTTGCAGCAGTTGCGCCAGTTCATCCGCTTCGCCGGCGTCGAGGGCGGGGCTGAGCGGCAGGTCGACGCTGAACCGGGTGCCCTTGCCCGGCTCGCTGCTCACCTCGATGCGCCCGCCCATCATCTGCACCAGCTCCCGGCTGATCGCCAGGCCCAGGCCGCTGCCGCCGTAGCGGCGGGTGGTGCTGGAGTCGGCCTGGGAGAAGGATTCGAACAGGGTCTTCTGCGCCTGGGCGGATATCCCGATGCCGCTGTCGCTGACGCTGTACAGCAGGCGCTCGTGTCCGCCCTCGTCGAAGCGCCGCTGCACGCGCACGGCGACATGGCCTTCGGCGGTGAACTTGAGGGCATTGCTGAGCAGGTTCATCAGTACCTGGCGCAACCGCGTCGGGTCGCCGTTGAGGCGGCGCGGCACGCCCCTGTCCAGGCCGAGATGCAGGCGCAGGCGTTTTTCCACGGCCTGGGCGCTGAACAGCGCCAGGGTGTCGGAGAGCAGTTCCTCCAGGTCGAAGTCGATGCGCTCCAGGTGCAGCTTGCCGGACTCGATGCGAGCGTAGTCGAGGATATCGTTGATCACCGACATCAGCGCGCTGCCGGAGCTGGCGATGGTCTCCACGTAGGCCGCCTGGCCGCGGTCCAGCGGGGTGTCGCGGAGCAGTTGCAGCATGCCCAGCACGCCGTTCAGCGGGGTGCGAATCTCATGGCTCATCTTCGCCAGGAAGCGGCTCTTCGCCTCGTTCTCCACCCGCGCCTGCTCGGCCGCCTGGCGCGAGCGGAAGCCTTCCTCCTTGAGCGCATTGATGCGGTCGGCGAGGCCGATGGACAGGGTCACCAGTTCCACGGTCATGCCGATCTTGACCACGCTGCTGCCGAACAGGCCGAACAGTTCGAAGCCCAGCGAGGCGGCGGTGGTGACCAGGAACGACAGCAGCAGCGCGCCCCAGGCCAGGATGTAGTAGAGGCCGTAGCGCAGGCCCTGGCGCCAGACGTGGACGCCGGCCAGCAGCAGGCTGAGGGAGACCAGCATCACCGTCAGGCTGGCGAGGACGTTCCAGGCGCGCAGCCCCACCAGCGGCTCGCTGGCCAACAGGACCACGCAGGCCAGCAGCAGGCCGCGGAGGAAGCGGTCGAGGCGCGGGAAGTCGCGGCGGGTGTAGAGGTAGCCGCGGCTGAACTGGATCGACACCAGGCAGCTCAGGTACATCAGCAGGTAGATGCCGGCCGACTCCAGCGCCACGTGTCCGGGCAGCAGCTTGAACAGCAGGCCGTCGAAGCTGGCGGAAAACAGGCCGAGGCTGAGGTTGTACAGCAGGTACCAGGCATAGGTGGCCTCGCGTAGCGAGACGAAGAGGAACAGGTTGTAGCAGAACAACCCGAACAGCACCCCGTAGAAGGCCCCGTTGAAGCCCATCAGGGTTTCCTGGCTGGCCGCGCTGGCCGCGTAGGTGCTGAAGTACAGCGGCACGTAGACGGTGCTGGTGCTCTGCACGCGCAGCAGCAGGGTGCTCTCGCCGGGCGGCAGTCGCAGCGGGAACCAGAAGTTGCGCACTTGCACCGGGCGCTGGGAGAAGGCGAACAGGTCGCCGCTCTCCTGCTGTTCGATGCGCCCATCGGCGGTCAGCAGGTAGACCTTGAGGTCGTCCAGCAGCGGGTAGTTGATCTCCAGGAAACCGGCCAGGTCGGTGCCGTTGCGGTTGTCCAGGCGCACCCTGAACCACCAGGCTGCGGCGTTCTTGCCGAAGTTCGCGTGGTCGCCGCGCAGGGCGGCGAAGGCCTGCGCCGGCAAGGCGAGGATGTCGCCCAGACGCGCCTTGCCGCCGGCGTCGCGGTAGTACTCGGCGTACTCGCCCAGGGACAGGCGCAGGTCCTCTCCGTCCAGCGGCGCGGGCGGCTGCGCCCGGGCCGGCAGCGCGCAGCAGAGCAACAGCAGGACCAGGCAGAGTCGAGACATGCAACTACTCCATGGACACGAGTCGGCACGCATGATGCTACGGAGGAAACGAGACAGGCGAGGGAACCTGCCATCAGCCTAGCAGTTGGCTGGAGAGGAGGGCGGCCTCCCCGGAGGCGGGGAGGCCGGCGCGGGCTCAGCCCTTGTCGCTGTTGTTGCTGCTGTCGAGCACTTCGTCCACCGGCGGGACGTGGGTGCAGCTTTCCATGTGCACCGGATGCTCGAGCTGCTTGTTGAAGCGTTCCAGCGAGGTTTCCCGGGGCTTGGCGTCGCTGGCGAAGACCGGCGGGCTGAGGATGTAGGCGGTGAGCAGCCGGCTCAGCGCGGCGAGACTGTCGATGTGCGTGCGCTCGTAGCCGTGGGTGGCGTCGCAGCCGAACGCCAGCAGCGCGGCGCGGGTGTCGTGGCCGGCGGCGATCGCCGACTGCGCGTCGCTGTGGTAGTAGCGGAACAGGTCGCGGCGCAGGGCGATGTCGTGGCGCTCGCCGAGCCGCAGCAGGTGCCGCGACAGATGGAAGTCGTAGGGCCCGCCGGAGTCCTGCATGGCCACGCTGACGCTGTGCTCGTTGGAATTCTGGCCTTCGGCCACCGGGGCGATGTCGATGCCGACGAACTCGCTGACGTCCCAGGGCAGGGCGCCGGCGGCGCCGGAGCCGACTTCCTCGGTGATGGTGAACAGCGGGTGGCAGTCGATCGGCGGCTCCTGGCCGCTTTCCTTGACCGCCTTCAGCGCCGCCAGCAGCGCCGCGACCCCGGCCTTGTCGTCCAGGTGGCGGGCGCTGATATGGCCGCTCTCGGTGAACTCCGGCAGCGGATCGAAGGCCACGTAGTCACCCACCGAGATGCCCAGGCTCTCGCTGTCGGCGCGACTGGCGGTATAGGCGTCGAGACGCAGCTCGATGTTGTCCCAACTGATCTTCAGGTTGTCCACCTCGGTATTGAAGGCGTGGCCCGAAGCCAGCAGCGGCAGCACGCTGCCACGGAACACGCCCTGTTCGGTGAACACCGTGACCCGGCTACCCTCGGCGAAGCGGCTCGACCAGCAGCCTACCGGGGCCAGGCCGAGGCGGCCGTTGGGCTTGATCTCGCGGACCAGCGCGCCGATCGTGTCGAGGTGCGCGGAAACCGCCCGGTCGGGGGTATTCAGGCGGCCCTGGAGGGTCGCCCGGATGGTTCCCCGGCGAGTCATCTCGAAGGGCACGCCAAGTTCGTCGAGCTGCTCGGCGACATAGCGCACGATGGTATCGGTGAAGCCGGTGGGGCTGGGGATGGCGAGCATCTCCAGCAGCACCCGTTGCAGGTAGTTGAGGTCCGGTTGTGGCAGAGGGGTCATGAAGGCACCTCGCGGCTGAGGGGGAAGAGAAGATCGACGAAGCGTTCGGCGGTCGGCTGCGGCTCGTGGTTGGCCAGGCCGGCGCGCTCGTTGGCTTCGATGATCACGTAGTCGGGCTGGTCGGCGGCCTCGACCAGGAAGTCCAGGCCCACCACCGGTATTTCCAGGGCCCGCGCGGCCTGGATTGCGGCCTCGCGGAGGGCCGGATGGAGGGCGTCGGTGACGTCCTCGAGGATGCCGCCGGTGTGCAGGTTGGCGGTGCGCCGCACGGCCAGGTGTTCGCCGCTGGGCAACACGTCGTCGTAGCCATAGCCGGCGGCCCGCAGGGTGCGCTCGGTCTCGTGGTCGAGCGGGATGCGGCTTTCCCCGCCGGTGGCGGCCTGGCGCCGGCGGCTCTGCGCCTCGATCAGCTCGCGGATGCTGTGCCGGCCGTCGCCGATCACCGCGGCGGGACGACGGATGGCGGCGGCCACCACCTCGTAGCCAATCACCAGCACGCGCAGGTCGTGGCCGGCGTGGTAGCTCTCCAGCAGCACGCGCGAATCGAAATGGCGGGCGGCCTCGATGGCCTCCTCGACCTCTTCCGCGGTGCGCAGGTCCACCGCCACGCCCTGGCCCTGCTCGCCGTCCACCGGCTTGACCACCAGCGAACCGTGCTCGGCGAGGAACGCGGCGTTTTCCTCCGCGCTGCCGGCCAGGCGCTGCTGTGGCTGGCGCAGGCCGGCGTGCTGCAGGGCGCGGTGGGTGAGGACCTTGTCCTGGCAGAGGGTCATGCTTACCGCCGTGGTCAGGTCGGAGAGCGATTCACGGCAGCGGATCTGCCGGCCGCCCTGGGTCAGGGTGAACAGGCCGCCCTCGGCGTCGTCGACGCGCACCTCGATGCCGCGCCGGTGGGCTTCGTCGACGATGATCCGGGCGTAGGGGTTGAGGTCTTCCTCCGGGCCGGGGCCGAGGAACAGCGACTGGTTGATGCCGTTCTTGCGCTTGATGGTGAAGGTCGCCAGTTCGCGGAAGCCGAGCTTGCGGTAGAGCGCCTTGGCCTGCTGGTTGTTGTGCAGCACCGAGAGGTCGAGGTAAGCCAGTTCGCGGCTCATGAAGTGCTCGACCAGGTGCCGTACCAGCGCCTCGCCGACGCCCGGCCGGCTGCATTGCGGGTCCACCGCCAGGCACCAGAGGCTGGAGCCGCCCTCCGGATCCTGGAACGCCTTGGCGTGGTTGAGGCCCATCACCGTGCCTACCGCGACGCCAGTGTCGGCGTCCTCGGCCAGCCAGTAGATCGGCCCGCCCTGGTGGCGCGGGCTGAGGCGCTCGGTCTGCACCGGAAGCATGCCGCGCGCCAGGTACAGGCGGTTGATCGCCGCCCAGTCCTCCTCGGTATGCACCCGGCGGATGCGGAAACCGCGTGGCGGACGGCGCGCCGGGCGGTAGTCGGTGAACCACAGGCGCAGGGTATCCGAGGGATCGAGGAAGAGCTGCTGCGGGGCGTGGGCCAGGACCTGCTGCGGCGCCGCCACGTAGAGCGCGATGTCGCGTTCGCCGGGGGCTTCCTGCAACAGGTCGCGGGCCAGTTCCTCGGCGTCCGGGTAGGTCTGCCCGATCAGCAGGCGGCCCCAGCCGCAGTGGATGCTCAGCGGTTTCTCGGTGGGCTCGCTGTGATCTTCGGCGAGACGCGCCTGGAGGCGTTCGTAGGTGGGCGCCTGGATACGTTGCAGGCGCTGGTTGTGCGGGTGAGGCAGATGCAAGTGGCCTTTCATGATCGCTCCTGGTTCGGGCCCCTGCGTTGGGGGCCCATTTTCAAAGTCCCTGTTCGCTGAGCCAGAGGTTGAGGGCGGCCAGCTGCCACAGCTTGGAGCCGCGCAGCGGTGTGAGGTCGCCGTCCGGATCGCTCAGCAGGCGATCGAATATCGCCGGCTGGAACAGGCCGCGGTCCTGGCTCGGGTCGAGCAGCAGTTCGCGTACCCATTCGCGGGTGCGGCCCTGCAAGTGCTTGAGGCCGGGCACCGGGAAGTAGCCCTTGGGCCGGTCGATGACTTCGCTGGGAATCACCTTGCGCGCGGCACCCTTGAGCACCTGCTTGCCGCCGTCGCCGAGCTTGAAGCGGGCGGGAATGCGCGCCGACAGCTCGGCCAGGCGGTAGTCGAGGAACGGCACGCGGGCTTCCAGGCCCCAGGCCATGGTCATGTTGTCGACCCGCTTGACCGGGTCGTCGACCAGCATGATCGTGCTATCCAGGCGCAGCGCCTTGTCCACCGCGGCCTCGGCGCCGGGGCTGGCGAAGTGGTCGCGGACGAAGCGCCCGGCGACGTCCTCGACGCGGAAGCGCTCGCCGACGGTGGCCAGGTATTCCTCGTGGTCGCGGTCGAAGAACGCCGCGCGGTACGCGGCGAAGGCGTCGTCGGCGCCATCCACCTTCGGATACCAGTGGTAGCCGGCGAACAGCTCGTCGGCGCCCTGGCCGCTCTGCACCACCTTGCAGTGCTTCGAGACTTCCCGCGCGAGCAGGTAGAAGGCGATGCAGTCGTGGCTGACCATCGGCTCGCTCATGGCGCGGAAGGCCGCCGGCAACTGCTCGATCACTTCGTGCTCGCCGATGCGCAGGCGATGGTGACGGGTGTGATAGCGCTCGGCGATCAGGTCGGAATACTGGAACTCGTCGCCGCGCTCGCCGCCGGCATCCTCGAAGCCGATGGAGAAGGTCAGCAGGTTGTCCACCCCGGCTTCGTGCAGCAGGCCCACCAGCAGGCTCGAATCGACCCCGCCGGAGAGCAGCACGCCGACCTCGCGGGCGGCGCGCTGGCGGATCGCCACCGCTTCGCGGAGGCCGTCGAGGACGCGCTCCTGCCAGTCGTCGAGCGTCAGCTCGCGCTCGTCCGGGCGTGGGCCGTAGTCCAGCGTCCACCAGGTGCGCTGCTCGCAGCTGCCGTCGAGGTCGACGCTCATCCAGGTCGCCGGCGGCAGCTTCTTCACGCCCTCCAGCAAGGTGTGCGGGGCGGGAACCACGGCGTGGAAGTTGAGGTAGAAATTCAGCGCCTGCGGATCGAGGTCGCTGGCGATGTCGCCGCCCTTGAGCAGGGCCGGCAGGCTCGAGGCGAAGCGTAGGCGCGAGCGGTCGAGGCTGTAGTAGAGCGGCTTGATGCCGAGTCGGTCACGGGCCAGGAACAGCCGCTGGCGATCGCGCTCCCAGACGGCGAAGGCGAACATCCCATTGAGCCGGGGCAATAAATCGGCGCCCCAGGCATGGTACCCCTTCAAGAGAACTTCGGTGTCGCCGCCGGAGAAGAACCGATAGCCAAGGCTTTCCAGTTCGCCACGCAGTTCGGGGTAGTTGTAGATGGCGCCATTGAACACCATGGCCAGGCCGAGATCGGGATCGATCATCGGTTGGCCGGAAGCTTCCGCCAGGTCCATGATCTTCAGCCGTCGATGTCCGAGGGCGATCGGACCCTGGGCGTGGAAGCCCCAGGCGTCGGGGCCGCGAGGGGCCAGGTGGTGGGTGATGCGTTCGACCGCTGCGAGGTCGGCTGCCTGGTTGTCGAAACGAAACTCTCCTGATATGCCGCACATATTCCTTACCGGTTCTCCGTTGGGGAAGTGGGTTGCGTACCCCTTCCGGGTACATGACTTACCTAACAGAGGACCGTTACAGTTGGAAGGAGTTCTATACGAATTTTCCGGGCCTATCAGGACCCTTAACGAAGAATTTATTATGGTTGAAAGTAATAAGACCGCTGCCGATACCTATTCGCTCGCTATTTTCCGCGCCATCCGCCGTCTCCAGCAGGCCGCCGAAATCCACTCCAAGCGTCTCAGCCGATACGGTGGCCTGACCCCGCTGCAATTGCTGATCCTGCATGTCCTGGCGGTGGAGGGAGAACTGACCGCGACGCAACTGGCCAAGCTGGTCAGCCTGTCCCAGGCATCGCTCTCCGGCGTGCTCGACCGCCTCGAAGGACGCGGCCTGCTCTATCGTCGGCGCGACGAACAGGACCGGCGCAAGTCCTGGCTGCACCTCGACCCGGCCGGCCACGAAGCCCTGGCGGAGGCGCCGCCGCTATTGCCGGAGTACGTGATCGAGCGCTTCGCCGCGTTGCCCGAGTGGGAGCGCCACGGCCTGCTGGCCGCGCTGCTGCGCGCGGCCGACCTGTTCGGCTTGCCGGAAGAGGACGTCGAAGAAGAGTGAGGGCGCCAGGTTCGCTACGAAAGACAGTCGCGTCGGCGGTCTTTACCTGGCGAACCTGCCGATGCCTGGTGGACAAGCGCGTTGTACGCCATGGCGTGACCTTCGCGTAGGGCGCATAACGCCGCTTCCCCGGTGCCCCGGCCGCCGAGGAAAGCTACCCGCCGTAGAGCTTCTGCGCCGCCAGGGAGAAGCTCACCGCCACCAGCATCAGCGCGAACAGGCGTTGCAGGGTCGGGCCGCCGAGGCGCTGCGCCAGCAGGTTGCCGCCGAGCACGCCGACCGCGCCGCCGGCGGCGAGGCCGCCGAGCAGCGGCAGCGGCGGGTGGGCGCCGGTCAGGTAGATCAGGAAGCCGCCGCCGGAGACCAGCGCGATCACCGCCATCGAGGTGGCGGTGGCGGCCATCATCGACAGCGGGGTGAACCAGAGTAGCCCCGGCACCACCAGGAAGCCGCCGCCCACGCCCATCAATCCCGACAGCAAGCCGACCGCCAGGCCGATGCCGAGCAGCGGCAGGCTCCGTGCCTGGTCGCTGGCCTCGCGTTTCATCCCGGCGCCGCGCCACATGCGCCAGGCCGACCAGAGCACCAGCAGGCAGAAGGCGACGATCAGCACGCCTTCCGGGACGAAGCGGCCGAGCCATTGGCCGACGGCGTTGCTCGGCAGGCCGGCCAGCGCCAGGACCAGCACCGGCCGCCAGGCCACCTGGCCCTGGCGCGCGCGCGGAATGGCGCCAATCAGCGCCGACAGGGCGACCGCGCCGAGGCTCACGCCGATGGCGTCGCGCAGCGGCAGGTGCAGGCTGAGCAGCAGGGGCAGGGCGACCAGCGAGCCGCCGGCGCCAGTGAGGCCGAGCAGCAGGCCGAGAACGGCGCCGATGCCCAGGGATTCGAAGAGCAGTACATCCATCGTCGATCAACTGTTTCCGCGGGTGAGCCAGCCGGTGGTCCGGTATGGCCTGCGCGTGCGGCAGGCCCGAAGGGTAGCGCAAATCGGTGCGCCCTGGGCTTCAGCCGCGCTGCCCGCGCACCAGGTCGCGGAGCAGGAAGCGGTTCGGGTGGCAGGCCTCGGCCACCGCGCGCGGCAGCGGCAGCGGCTCGCCGCAGATCCACGCCGCCAGCAGTTCGCCGGACAGCGGCGCACTGATCAGCCCGCGCGAGCCGTGGCCGCTGTTCAGGTACAGGCCTGGCAGCCAGGGGCAGGCACGCTCCGGCGCCTGGCGGGCGTCGCGGGCGAGCACCGCGTAGGCCTCGTCGAAGGCCGCGCGCTCGGCCAGCGGGCCTACCAGGGGCAGGTAGTCGGGGCTGGTGCAGCGGAATGCCGCGCGGCCTTCCAGGCGCTCCAGCGGCAGGTCGTCGGCGCCCAGGCGCTGCAACAGGTCGGGGGATATTTCCCGCAGCAGTTCGAGGTTGCCCTGGTGTTCGGCGAGGGTCGGCGCCAGGTCTTCGCTCTTGAAGTCGAAGCTGGCGCCGAGGGTGTGTTCGTCGCCACGCGGCGGTGCGACGTAGCCCTCGGCGCAGACCACGGTGCGCAGCGCCCGGCTTTGCGGGGTGGCCGGCAGGCGGGTGACCTGCCCGCGAATGCGCTTCAGCGGCAGCTCGGCGGCGGGCGGGAAGTCGCGGATGTCGGCGGCGGTGGCGAGGATCGCGAGTGGCGCGCGGGCCAGGCATTCGTCGCCGGCGTAGGCGCACCAGTCGTCGCCCTCGCGGCGCAAGCGTACTGCCCGGCCGCTCAGCAGGGTGATCCCGGGGGTGGCGGCCAGGGCCTGGCACAGCGCGGGCGGATGGACCCAGCCGGCTTCGGGATAGAACAGGCCGCCGGCGGGCAGGGCGACGCCGGCGAGGCGCTCGGCCTGCTCGCGCTCCAGGCCGTGCAGCAGGTCGGCGGGGAAGGCTGCGGCCAGTTGCGCCTGGCGTTGCGCTTCCTTGGCGTCGAAGGCCAGTTGCAGTACGCCGCAGGCATCCCAGTCGTGGCCGCGCCGCAGGCGTTCGAGCAGCCGGCGGGTATGGCCGAAGCCGCTGAGCACCAGGCGCGACAGCGGCGTGCCGTGGGCCGAGAGTTTCAGGTAGAGCACGCCTTGGGGGTTGCCCGAGGCTTCCCGGGCGAGGCCGGGATGGCGTTCGATCAGGGTCACCTGCCAGCCGCGCGCGGCGAGGCTGGCGGCGCTGGCGCAGCCGGCCAGGCCGCCGCCGACCACCAGTGCCGCGCGGCGCCCGGCGTGGGGCGCGGGGCGTGCGTACCAGGGCTTGCCGGCGTTCGCCGGCGGCCCCTGGTAGGTGCCGCTGAGCATCTCGCGCTTCTGTCCGTAGCCCGGTACCCGTTGCATGGCGAAACCGGCCTCGACCAGCCCGCGGCGAACGAAACCGGCGCTGGTGAAGGTGCCCAGGGTCGCCTGCGGCGCCGACAGTCGCGCCAGTTCGGCGAACAGTACGGGCGACCACATGTCCGGGTTCTTCGCCGGGGCGAAGCCATCGAGGAACCAGGCGTCGACCCGCGCGTCGAGCTGCGGCAGGCACTCCAGGGCATCGCCCAGCAGCAGGGTCAGGCCGACCCTTCCGCCCGCGAACGCCAGGCGCTGGAAGCCCGGGTGCACGGCAAGGTACTGGCCCAGCAGGGCCTCGCTCCAGGGCGCCAGTTCCGGCCATAGCGCCAGGGCGCGGCGCAGGTCGGCGGCGGCGAGGGGGAATTTCTCCACGCTGACGAACTCCAGGCGCGCGCCGGCCGGCGCGACCCGCTCGAACAGCTGCCAGGCGCAGAGGAAGTTTAGTCCGGTGCCGAAGCCGGTCTCGCCGATACACAGCACCTCGCCGTCGCCCAGCGCGGCGAAGCGCTCGGCCAGGCGGTTGGTGGCGAGGAACACATGGCGCGTCTCGTTGAGCCCGGAATGCCGGGAAAAATATACGTCGCCGAAGGCGCGGGATAGCGGCTGGCCGTTTTCGTCCCAGTCGAGCTGGGCATGCTGGAAGTCGGACATGGCAGAACCTGAAAAAGCGGATGGCGCATTTTACGGGGCTTTGCCGGCCAGCGGCGAGGCGCTGCGCGAACATGCCGCGGCGCCGCGCAGACAGCCGCACGCCGATCCGCTACCTTGAAGGACTCAGGTTAAGGGAGACCTCCATGTTCGAATCCGCGGAAGTTGGCCACAGCATCGACAAGGACACCTACGAGAAGGCCGTCATCGAGTTGCGCGAAGCGCTGCTCGAGGCGCAGTTCGAGCTCAAGCAGCAGGCGCGCTTCCCGGTGATCATCCTGATCAACGGCATCGAGGGCGCCGGCAAGGGGGAGACGGTCAAGCTCCTCAACGAGTGGATGGACCCGCGCCTGATCGAAGTGCAGAGCTTCCTCCGTCCCTCCGACGAGGAACTGGAGCGGCCGCCGCAGTGGCGCTTCTGGCGGCGCCTGCCGCCCAAGGGGCGGACCGGTATCTTCTTCGGCAACTGGTACAGCCAGATGCTCTACGCGCGGGTCGAGGGGCATATCAAGGAGGCCAAGCTGGATCAGGCCATCGATGCCGCCGAACGCTTCGAGCGCATGCTCTGCGACGAAGGCGCGCTGCTCTTCAAGTTCTGGTTCCACCTCTCCAAGAAACAGCTCAAGGAACGCCTCAAGGCGCTGGAAAAGGACCCGCAGCACAGCTGGAAGCTCAGTCCGCTGGACTGGAAGCAGAGCGAGGTCTACGACCGCTTCGTGCATTACGGCGAGCGCGTGCTGCGCCGCACCAGCCGGGACTACGCGCCCTGGTACGTGGTGGAAGGCGTGGACGAGCGCTACCGCGCCCTGACCGTCGGTCGCATCCTCCTCGAAGGGTTGCAGGCCGCGCTGGCCACCAAGGAGCGCGCCAAGCGCCAGCCGCACGCCGCGCCGCTGGTGTCGAGCCTGGACAACCGCGGCCTGCTGGACTCCCTGGACCTGGGCCAGTACCTGGACAAGGACGCCTACAAGGAGCAGCTCGCCGCCGAGCAGGCCCGCCTGGCCGGGCTGATCCGCGACAAGCGCTTCCGCCAGCATTCGCTGGTCGCGGTGTTCGAGGGCAACGACGCGGCCGGCAAGGGCGGCGCCATCCGCCGTGTCACCGACGCGCTGGACCCGCGCCAGTACCATATCGTGCCGATCGCCGCGCCGACCGAAGAGGAGCGTGCGCAGCCCTATCTCTGGCGCTTCTGGCGGCACATTCCGGCGCGTCGCCAGTTCACCATCTTCGACCGTTCCTGGTACGGCCGCGTGCTGGTGGAGCGCATCGAGGGCTTCTGCGCACCGGCCGACTGGCTACGCGCCTATGGCGAGATCAATGACTTCGAGGAGCAGCTCAGCGAGTACGGGATCATCGTGGTGAAGTTCTGGCTGGCGATCGACAAGCAGACCCAGATGGAGCGCTTCAAGGAACGCGAGAAAACCCCCTACAAGCGCTACAAGATCACCGAGGAAGACTGGCGCAACCGCGACAAGTGGGACCAGTACGTGGACGCGGTGGGCGATATGGTCGACCGTACCAGCACCGAGATCGCGCCCTGGACCCTGGTCGAAGCCAACGACAAGCGCTTCGCCCGGGTCAAGGTGCTGCGCACCATCAACGACGCCATCGAGGCGGCGTACAAGAAGGACAAGTGAGGCCTGCCGGAATGCGGCGCCGTCCTCTCCAGGGGATGGCGACGCATACGCCGGATGAATGATCGGTGCCTCGCGCGATTGCCTCGCCTTATCCTCGCTCGATCCGGCCGCTGCCCCGGCGGCCGACCGACAATAACAGCGAGGGTACCCCCATGCGTGAAGTGGTGATCGTCGACAGCGTCCGGACCGGCCTGGCCAAGTCCTTCCGCGGCAAGTTCAACCTGACCCGGCCGGACGACATGGCCGCCCACTGCGTCGACGCGCTGCTGGCGCGCAACGACCTCGACCCGCTGCTGGTGGATGACTGCATCGTTGGCGCCGGCTCCAACGAAGGCGCCCAGGGCCACAACATCGGGCGCAACGTGGCGGTGCTCTCCGGCCTCGGCATCCAGGTGCCGGGGATGACCCTCAACCGCTACTGTTCCTCCGGCCTGCAGGCGATCGCCATCGCCGCCAACCAGATCGCTTCCGGTTGCAGCGAGGTGATCGTCGCCGGCGGCGTCGAGTCGATCACCCTGACCCTGAAGAGCGTCAACACCGACCACCTGGTGAACCCGCTGCTGCAAAGGGAGGTGCCGGGCATCTACTACCCCATGGGGCAGACCGCCGAGATCGTCGCCCGTCGCTACGGCATCACCCGCGAGGCCCAGGACGCCTACGCCCTGCAGAGCCAGCAGCGGATGGCGCGAGCCCAGGCGGACGGGCTGTTCGCCGACGAGATCGTGCCGATGACCACCCGCTACGCGGTGGAGGACAAGGCCAGCGGCGAGAAGCAGGTGCTCGACGGAGTGGTCGACCGCGACGACTGCAACCGCCCGGACACCACCCTCGAAGGCCTGGCCTCGCTGAAGCCGGCGTTCGCCGAGGACGGTTCGGTCACCGCCGGCAACGCCTCGCAACTCTCCGACGGCGCCTCGATGACCCTGCTGATGAGCCTGGAGAAAGCGCTGGCGCTGGGCCTGGAGCCGAAGGCCTTCTTCCGTGGCTTCACCGTGGCCGGCTGCGAGCCGGACGAAATGGGCATCGGTCCGGTGTTCTCGGTGCCGAAGCTGCTCAAGGCGAAGGGGCTGAAGATCGCCGACGTCGATCTCTGGGAACTCAACGAAGCCTTCGCCTCGCAGTGCCTGTACTGCCGCGACCGGCTGGAGATCGACAACGAGAAGTACAACGTCAATGGCGGCTCCATCGCCATCGGCCACCCGTTCGGCATGACCGGCTCGCGCCAGGTCGGTCATCTGGTCCGCGAACTGCACCGGCGCAACCTGCGCTACGGCGTGGTGACCATGTGCGTCGGCGGCGGCATGGGCGCCAGCGGGCTGTTCGAAGCCGTACGCTGAGCCCGTGCGCGACGGCGGGCCCCGCAGGTCGGGGCTCGCCTCATGGGTTTTATTTACATGACGCTCCGTGCCATCCCCGGCGACTCGCGCTAGGCTAGGCGCCTTTTTCCTTGCATAGGGATGTAGCGATGTCCACCGAGCCCAACTCGCCGTTCGTCGACGACCCGCTGAGCGCCGTCGATGCACGGGTTCTCGGCAGCCTCGTCGAGAAGCAGGCGACCACCCCGGAAACCTATCCGCTGACCCTCAATGCCCTGGTCCTCGCCTGCAACCAGAAGACCAGCCGCGATCCGGTGATGAACCTCACGCCCGGCCAGGTCGGCCAGAGCCTGCGCCAGCTCGAGGGGCGCGGCCTGGTCAGGCTGGTGATGGGCAGCCGCGCCGACCGCTGGGAGCACACCCTGGGCAAGGGCCTGGAATTGGTGGCGCCACAGGTGGCGCTGCTCGGCCTGCTGTTCCTGCGTGGTCCGCAGACCCTCAACGAACTGCTCACCCGCAGCAACCGCCTGCACGATTTCGACGACGTCGAGCAGATCCGCCACCACCTGGAACGCCTCGCCGGCCGTGGCCTGGCCGTGCACCTGGAGCGTCGCGCCGGGCAGCGCGAGGAGCGCTACATGCACCTGCTCGGCAGCCAGGCCGACCTCGAGGCCGCCGTGGAGGCGATGGGCAGCGACCCGGAACGCGCCGCGCCGGCCGCTCTGTCGGCCGATGCGGAAGCGCGGATCGCCGAGCTGGAGACGCGCCTGGCGGCGCTGGAGGAGCGCCTGGCCAGGCTCGAAGGAGGGGCGTGATATCGCGGGAGGGCGCAATCGGTGACATGCAGGTTCCGGCGGATAACCGCGAGCGGTTGTTCGCCCTACGGCCCGCAGTGACTTTGTGGGCGGCGCTGCCTGTCGGGTAGGGCGGATAACGCCAGCGGCGTTATCCGCCGATGCGCCGCCCCGCAAGGCGAACGCCAACCCAAAAAAGCCCGGCTATTGCCGGGCTTTTTCATGCGCGCGCGTCGGTGGCCGATCAGGCCTCCGGCTGTACCGGCACGTGGATCAGTTGCAGGCGCTCGCTGCTCCAGGCACGGGTGCTGTTGGTCAGCTCGATGTCGTTGTTCAGCTTGCGCCCGTAAGACGGCACGATTTCCTTCAGGCGTGCCTGCCACTCGGGAGTAGCGACCTTGTCCTTGAAGGCCTTCTCCAGCACCGACAGCATGATCGGCGCGGCGGTCGAGGCGCCCGGCGAGGCGCCGAGCAGGGCGGCGACGGAGCCGTCGGCGGCGGTCACCACTTCGGTGCCGAATTGCAGTACGCCGCCTTTCTCGGCGTCCTTCTTGATGATCTGCACGCGCTGGCCGGCCTGCACCAGCTTCCAGTCCTCGTCGCGGGCTTCCGGGAAGTACTCGCGCAGCGAGGCCATGCGGTCGTCCTGGCTGAGCATCAACTGGCCGATCAGGTACTGGCTGAGATCGAAGTTGTCGATGCCGGCGTTGAACATCGGGCCGATGTTGCCGCTGGTCACCGAGCCCGGCAGGTCCCACAGCGAGCCGTTCTTCAGGAACTTGGTGGAGAAGGTGGCGAACGGACCGAACAGCAGAACCGGCTTGCCGTCGATCATGCGGGTGTCGAGGTGCGGCACCGACATCGGCGGCGAACCCACCGAAGCCTTGCCGTAGACCTTGGCCAGGTGGCGCTTGACCACGTCCGGGTTGGTGGTGGCGAGGAACGAACCGCCCACCGGGAAGCCGGCGTAGCCTTCGGCCTCGGGGATGCCGGACATCTGCAGCAGCTTCAGCGCGCCGCCGCCGGCGCCGATGAAGACGAACCTGGCCTTGACGCTGGTTTCCTTGTCGCCATTGGCCAGGTCGGCCATGGTCACGGTCCAGGTGTTGTCGTCGTTGCGCTTGAGGTCGCGGACCTCATGTTGCAGGCGCAGCTTGAAGGTGTCCTTGGCCGACAGCGAGCCCACCAGTTGGCGAGTGATCTCGCCGAAGTTGACGTCGGTGCCGATCGACATGCGCGTGGCGGCGATCTTCTGCCCCGGCTCGCGGCCTTCCATCACCAGCGGCACCCACTGCTTGATCTGCTCGGGGTCTTCCGAGTACTCCATGCCGCGGAACAGCGAGCTGTGCTGCAGGGCGGCGTGGCGCTTCTTGAGGAAGGCGACGTTGTCGTCGCCCCAGACGAAGCTCATGTGCGGGACGTTGTTGATGAACGACTTCGGATCGTTCAGCACCTTGCGGTCGACCTGGTAGGCCCAGAACTGCTTGGAGATCTCGAAGTTCTCGTTGATCGCCACCGCCTTGCTGATATCCATCGAGCCGTCCGCGGCCTCGCTGGTGTAGTTCAGTTCGCAGAACGCCGAGTGACCGGTGCCCGCGTTGTTCCAGCCGTTGGAGCTTTCTTCGGCGACCTTGTCCAGGCGCTCGACCATCTCGATGGTCCAGCCCGGTTCCAGTTCGTTCAGATAGGTACCCAGGGTGGCGCTCATGATGCCGCCACCGATCAGGAGCACGTCGACCGGTTTTTCCGATTCGACGCTGTTTTTGGAGCAACCCAGCACGCTGACGCACAAAAGCATCAATAAGATTTTTTTCATGGATTTACCGCTAGAAAACGTGGAGAAGCGTGGATACGCACGACATGGCAGGTATTCACCGGGTGAATGATACTGGAACTCACCCCCGATGTGAGTGCGTTCACATGCGGTGACATTTGCCTCGGCGTTCCGCCGAGAATACCTGCCTTCCCTTTCTTGAACGTTTCAGCCACCGGGAAATAAATTCAGCGCCTGTATCGTTTCAGCGGGAACCCGGCGCGTGGATTTCCGCCGATTGGCGCATCCTGCGGATATACGCGTCGATTTCCCGCTCCGCGTCGAAACGGGTGAAATAGGGACCTTCCAGGGTCCCTTCGCGGGTGGAGAAGAAGTACTGCCCATTCACCGAACTTATGCGATCGCTGCGAAAGCGGGTGGCCGGGGTGGGATCGGTGGAACGTTTCCCCAACATGACGGCGACTCCTCGATAGCGGGCCAAGGTGTTTTCAGTGTAGGCGGGGGTTGGCCGGGCGGCAGGCCGGCGGACGAAAGGAGACGGATTTCCAGGCGAAGGGTTGGGTATTCTATTTTTGGTTATAAGAAAATCTGAATTTATTCTTTTTAACGTCAGCCGGCCTTGGGCATAGTGGGCTCCAACACGAACAAGGAGTGACCCCATGAGCCTCAGACTCGGCGACATCGCCCCCGATTTCGAACAGGACTCCAGCGAAGGGCGCATCCGCCTCCACGAGTGGCTGGGCGACAGCTGGGGCGTGCTGTTCTCCCACCCCGCCGACTTCACCCCGGTGTGCACCACCGAGCTGGGTTTCACCGCCAAGCTCAAGGACCAGTTCGCCCAGCGCGGGGTCAAGGTCCTGGCGCTGTCGGTGGATCCGGTGGAGTCGCACCTGAAGTGGATCGACGATATCAACGAGACCCAGGACACCCGGGTCAATTTCCCGATCATCGCCGACGCCGACCGCAAGGTTTCCGAACTCTACGACCTGATCCACCCGAACGCCAACGACACGCTGACCGTGCGTTCGCTGTTCATCATCGACCCGAACAAGAAGGTGCGCCTGATCATCACCTACCCGGCGAGCACCGGGCGCAATTTCAACGAGATCCTCCGGGTGATCGATTCGCTGCAACTGACCGACGAGCACAAGGTCGCCACGCCAGCCAACTGGGAGGACGGCGACGAGGTGGTAATCGTGCCTTCGCTGAAGGACGAGGAAGAGATCAAGCGGCGTTTCCCCAAAGGCTACCGCGCGGTGAAGCCCTACCTGCGCCTGACGCCCCAGCCCAACCGCTGAGGCCGGATTCGTCCCGCCTGCATGGGCAGGCACGGCAGGCGGGACCTTTTATTCGACGGTGCGTGCCGTCATGCAACGCTGTTTAGCCACGAGCAGGGTTTTTGGCCGGTTTCGACCGGCCCTCTTTTTTATGTGCGCCAGCGCGTCGCCGCGACGCTTTTTATCCGCCATCCATTTCCGAAACCGGCTCTGACTTGCCCGCCAGACGGGGAGAAGGCTCGCTCATCCACCTCCTTCCAGGAGCAGACGCATGATCGCCGCTCTCCGTCGCTGCCGGGCCTGGCTGGCCCTGCTCGCCGTTCTTGCCGTGTTTCCCGCGGCAGAGGCCGTCGCCCCCGCTGAAATCCGTCTCGACTATGCCTACTACGCCCCCACCAGCCTGGCGCTCAGGAAGTTCGGCTGGCTGGAGAAAAGCCTGGACGGCAGCGGCACCCGGGTGCGCTGGGTGTTCAGCCAGGGCAGCAACCGTTCCCTGGAGTACCTCAACGCCGGCAGCGTCGATTTCGCCTCGACCGCCGGCCTCGCCGCGGTACTCGCGCGGGCCAACGGCAGCCCGGTACGTACCGTATACGTCGCCAGCCGCCCGGAGTGGACCGCGCTGCTGGTGCGCAAGGATTCGCCGATCCGCAGCCTCGCCGAGCTCAAGGGGCGCAAGGTGGCTGCCACCAAGGGCACCGATCCCTACCTGTTCCTGCTCCGCAGCCTGCACAGCGTGGGCCTGGACAAGAACGACCTGCGTATCGTCCACCTGCAGCATCCCGACGGCCGGGTAGCCCTGGAGAAGGGCCAGGTCGACGCCTGGGCCGGACTCGATCCACACATGGCGGCCAGCGAGTTGCAGGCCGGCTCGCGGCTGCTCTACCGCAACCTCGGCTTCAACAGCTACGGCGTGCTCAATGTCCGCGAGGATTTCGCCGAACGCCATCCGCAACTGATCCGCCAGGTGCTGGCGGCCTACGAGCAGGCGCGCCACTGGGTGATCGGGCATCCCGACGAGGCCGCGCAACTGCTTGCCGAGGAAGCCGGCCTGCCGCTGGAAGTGGCTCGCCTGCAACTGTCGCGCACCGATTTCAGCCAGCCGCTGCCGGGCGCCGAACAGGTCGCCGCGCTCAAGGCCGCGGCGCCGATCCTGGCGGACGAGCGCCTGGTGCGGCCGGGCGTGGACGTGCAGAAGGTGGTCGACGAACTGATCGCGCCGCAGTGGGCCGCCGAGGTCATCGGCGGCGCCCCGTTGGCACGCACGGAGCCCTGAGCCATGGTCAGCCAGAGCCTGCGACTGGCCCGGCGAGTCTCGCGCCGGGCGTGGCGACTGCGCGTGCCGGGCGCCTGGCGGGCCTGGGCCTTGCCGCTGCTGGCACTATCGTCGTGGGAGGCGCTGGTGCGCCTGGGCTGGCTGCCGGCCTACCAGATGCCGGCGCCGAGCGGCATCCTGCTGACCCTGGTGGAACTGGCTCGCGGCGAGCTGTGGGGGCATGTCGGCGCGAGCCTGGCGCGGGTCGCCGCCGGCTTCGCGATCGGCAGCGGCCTGGCCCTGGTGGTCGGTACCTGGGTCGGTCTCAGTCGTCGCGCCGAAGCCTACCTGGAGCCGAGCTTCCAGGCCCTGCGGGCGATCCCCAGCCTGGCCTGGGTGCCCCTGCTGCTGCTCTGGTTCGGCATCGACGAGACGCCGAAGATCGTCCTCATCGCCCTCGGCGCCTTCTTCCCGGTCTACCTCGCGCTGGTCGCCGGGGTACGCGGGGTCGATCGCAAGTGGGTGGAACTGGGGCGGCTCTACCGTTTGTCGCGCTTCGCCCTGGTCCGCCGCATCCTCCTTCCGGCGGCGCTGCCGAACCTGTTCACCGGCCTGCGCGGGGCGCTCAGCCTGAGCTGGATGTTCCTCGTCGCGGCGGAGCTGATCGCCGCTACCCAGGGCCTCGGCTACCTGCTCAGCGACGGTCGGGAAACCTCGCGTCCGGACTTGGTGATCGCCGCGATCCTGGTCCTGGCGGCCCTCGGCAAGCTCAGCGATGGCCTGCTCCGCTCGCTGGAGCGCCGGGCCCTGCGCTGGCGCGACAGCTTCGACGGGGAGGGTGGCGCATGAGCGGCCTGCTCGACCTGCTGGAGATTCGCAAGGCCTATGGCGATACGCGGGTGCTGGAGGGCGTGGCGCTGTCGCTGGCGCCCGGCGAGGTGGTCAGCCTGCTCGGCCCCAGTGGTTGCGGCAAGAGCACCCTGCTGCGGATCGCCGCCGGACTGGACGATGACTTCCAGGGCACTGTCGAACGCAACCCGATCCTCGGCTTCGGCCCGGACGGCGAGAACGGCCGCAGCGGCGGAATCGGCGTGGTGTTCCAGGAGCCGCGCCTGTTGCCCTGGCTGACGGTGGCGCAGAACGTCGGTTTCGCCGACGGCTGGCTGGAGGACGAGCACTGGGTCGAGCGCCTGCTCGCCGATGTCGGACTGGCCGGCTGCGGAGGATTGCTGCCCAAGCAACTGTCCGGCGGCATGGCGCAGCGCGCGGCGATCGCCCGCGGTCTCTACGGACGGCCGCAGGTGCTGTTGCTCGACGAGCCGTTCAGCGCGGTCGACGCCTTCACCCGCATGCGCCTCCAGGACCTGCTGCAGGACGTGGTGCAGAACTACGAGATCAGCGTCCTGCTGGTCACCCACGATCTCGACGAGGCGTTCTATCTCGCCGACCGCGTGCTGCTGATGGGCGGCCGTCCCGGACACATCCGCCGCGAGTTCCACGTACCGCTGGCGCGTCCCCGCGATCGCCGGGCGGTGGAGCTGGCCTACTTGCGCGGCGAGGCCCTGACCGAAATGCAGCGGGCGCACGTGCTCTGAGGCAAGACCCCGAACCGGGTTTTTATATGCTTTATGGAATAAATAAATGAATAAAAAACATTTATTGGAATATGAGGCCGCCTGTTAAGGTCTATGCAACTTGGTTAGCAAGCCAAACGAATATTCTGTTTTCCGGTTATAAGGAATCCCCCCATGCTCGTCGTTTCCATCGCCGGAAGTCCCAGCGTACGCTCCCGCTCCGGGGTGTTGCTGGAGCGTGCCAGGGACTGGCTGAGCCGTCGCGGCGTCGAGGTGGCCAGCCACCAGGTGCTGGATTTTCCCGCCGAAGACCTGCTGCGTGCCCGCCTCGACAGTCCGCCGGTACTGGCGCTGGCCGAGCAGATCGGCCGCGCCGACGGCCTGCTGGTCGCCACCCCGGTGTACAAGGCCTCGTTTTCCGGCGCGCTGAAGGTCCTGCTCGACCTGTTGCCCGAGCGCGCCCTGGAGCACAAGGTGGTGCTGCCGTTCGCTACCGGTGGCAGCAGTGCGCACATGCTGGCCGTGGACTATGCATTGAAGCCGGTCCTGGCCGCGCTCAAGGCCCAGGAGGTACTGCATGGCGTATTCGCCGTGGACAAGCAGATCGCCTACGCCACCGAGAGCGACCCGGCGCGCCTGGAACCGGTCCTCGAGCAGCGCCTGGAAAACGCCCTGGAAACCTTCCACCTGGCCCTCTCGCGACGGCCGCAGCCGATCGACCCGCAGTTGCTCAACGAGCGCCTGGTGAACGCCCGCTGGAGCATCTGATCCGTCCGCCGCCAGCGCACGCGCGCCGCGGCCCGATTGCACAACGCACACACGACGACCTCACTGTTCCGTCAACGGCGCGGCAGGTTCGGCACCCACAACGACAAAGGAGAGCGCCATGCGCACCATCGCTTTGCGTCGTGGACTGGCGGCCCTGCTGGTGGCGGCCCTGTCCTACGGCGTTCAGGCCGACGAGAAGTCGGCCAACACCCTGCGGATCGGCTACCAGAAATACGGCACCCTGGTCCTGCTCAAGGCCCGCGGCACCCTGGAGAAACGTCTCGCCGAAGACGGCGTGAAGGTGCAATGGACCGAGTTTCCCGGCGGCCCGCAACTGCTCGAGGGACTCAATGTCGGCAGCATCGACTTCGGCGTGACCGGGGAAACCCCGCCGGTCTTCGCCCAGGCCGCCGGCGCCGACCTGCTCTACGTGGCCTACGAACCGCCGGCGCCGACCAGCGAGGCGATCCTCCTGCCGAAGGACTCGCCGATTCGGTCGGTGGCCGAGCTGAAGGGCAGGAAAGTCGCCCTGAACAAGGGCTCCAACGTGCATTACCTGTTGGTCCGCGCCCTCGAGCAGGCCGGCCTGAAGTACAGCGACATCCAACCCGTCTACCTGCCGCCGGCCGACGCCCGCGCCGCCTTCGAGCGTCACAGCGTCGACGCCTGGGTGATCTGGGACCCCTACCAGGCCGCCGCCGAGAAGCAGTTGTCCGCGCGGGTCCTGGTGGATGGTCGCGAGCTGGTCGACAACCACCAGTTCTACCTCGCCACCCGGACTTACGCGCAACGGCATCCGCAGGTGCTCGACAAGCTGGTGGACGAGATCCGCGAGGTCGGTGATTGGTCGCGGGCCAACCCGCAGCAGGTGACCGAGCAGGTCGCGCCGCTGCTCGGGCTGCCCGCCGACATCACCCTTACCGCGGTGAAGCGCCAGGGTTACGGCGCGCAGTTGATCACCCCGGCGGTGGTCGAGGCGCAGCAGAAGATCGCCGACACCTTCACCCAGCTGAAGCTGATTCCCAAACCGCTGAGCATCAAGGACGTGATCTGGACGCCACCGGCCGGCAAGGTCGCCAGCGCACCCTGAGCCCGTACCGCCCACATACCGACACGATCATCGCGCGGCTACGCCACGCCGGCGCGCTCACCCTGGAGTCAATTGCGATGAGCCTCGAGATTTTCTGGTTCCTTCCCACCCACGGCGACGGCCACTACCTGGGCACCACCCAGGGCGCCCGTGCCGTCGACCACGGCTACCTGCAGCAGATCGCCCAGGCCGCCGACC
+>8_2#NODE_7_length_39998_cov_63.2738_ID_13
+CTACTTGCTGTAGCAGCAGGACAAAAGGTAATTGATCAAGTTACTAATCATTCACCTTTTATGGAAATGATCATTGTTTGGATTGTGGCGACGACATTTCAACAATTTTTACCATCCCTTTCGACAATGGTTCAAGGAGTTCTAACTGATAAATTAACAGGCTTTATCAATATTAGCTTGATGAAAAAATCAGCAGACTTACAATCGATCAGTATTTTTGATGATAGTAAGTATTTTGATGATTTACAAATGCTCAGAGATGATGCAAGCTGGCGTCCGGTTAATTTAATTGTTTATGGAGTATCAGTCTTACAGTCATTTCTAACGCTAGCTTTCATGCTAATATATTTGGCACGATACAATTGGTGGCTAGCCTTGCTTTTATTAGTAGTAATGGTACCGCAGAGTCTTTCTTACTATCGTATTCAGCAGCAGTCATTTGAAACAATGGTTGAAAGAAGCAAGAATGCGAGATACTTGCACTACTATAGTGGATTGTTGCTTGATCGCAGGGATGCTAAAGAAGTTAGACTTTTCAACATGTTTCCTAAGATCATCGAAAAGTATACAAGCTTATTTGAACAAACGAAAAAAGACGTTAACCAAATTCGTAAAAAGCAACTTGCGACTAGTTCACTGTTTGTTGTATTGACTGTCGGAGTGTTTGGCTATGGCTTTTATTGGTTTACTAATTCAGTAAGAACAGGTGCATTAGAAGTTGGCGTATTATTGATGTTTGTTTCAGTAATTGGCTATATTTCTACTAGCATGGCTCGGGTAGTAGAAGACAGCAGCTTGTTATACGATTCATTATTATGGGTTGAAAAATACTTTAAGTTTCTTGAGTATCAAGATGATTTCAAAAACGGTGGTCAGAACTTTCCTGATGATTTTGATGATATTAATATTAAGAATCTGTCTTTTACATATCCGTTTTCTGATACTGAAATTTTGCACAATGTTAGTTTCTCAGTTAAAAGTGGAGAAAAAGTTGCAATTGTTGGAGAAAATGGGTCAGGAAAATCCACTCTGGTAAAGCTATTAATGCGTTTTTATGACCCGACTAATGGAAAAATTTCTGTTGATAATTATGATTTAAAAGACTTTAATATCTTCGACTTACATAAAAATTTATCAGCTACTTTTCAGGATTTTTCTCGCTTTAAATTAACGCTTAAAGAAAACGTGATTACCGGATATTCATTCAATAAAGGTAGGGTAAATAATGTTCTTAAAGCAGCAGGATTGGGTGATTTGCTAGCTAATGATCATCTTAATCTGAATACGATGCTGGCTAAAGATTTCGAAAATGGAACTGATTTGTCAGGTGGTCAATGGCAAAAAATAGCTTTAGCACGAGACTTATATGCTAATGGCAAGATTGAATTTTTAGATGAACCAACGGCAGCCTTAGATGCTAAGAGCGAATCGGAAATTTATCAACGCTTTTTGAAAGAAAATGATAAAAAGACAATTTTCTTTGTTACTCACCGTTTGTCAGCAGTTAGATTTGCTGATAAGGTATTATTTCTTGACGGTGGAAAAGTTAGTGGATTTGACACGCATACTAATTTATTGCAAACTAATCCAAAATATAAAGAAATGTACGACTTACAGAAAAATGCATATCTGTAAAGTTAAATTTTGATAGATAATAAAATTCTTCATGCAAGCAGGCATGGAGAATTTTTTTGCCTTTTAACAGTTAAGATTTTTCAGTGATTTTTACGTTATAATAGAACATAGGTTTTTGGAAGAAAGGATATTTGGTAACGAATGGCAAAAAAAGATACGACACCAATGATGAAGCAATACTACGAAATTAAGGAACAATATCCCGATGCGTTTTTGTTTTATCGTGTGGGCGATTTCTATGAATTATTTGAAGACGATGCAGTTAAGGGTGCACAAATTCTAGAGTTGACCCTAACTCATCGTTCAAATAAAACTAAAAATCCAATTCCAATGGCAGGAGTTCCTCACCTAGCTGTGGATACTTACGTTAATACTTTGGTGGAAAAGGGATATAAAGTTGCGCTTTGTGAACAACTTGAAGATCCAAAAAAAGCTAAAGGAATGGTAAAGCGTGGAATTATTCAGTTAATTACGCCAGGTACCATGATGCACGAACGTCCTGACCAAGCAAAAGACAGTAACTACTTAACGTCAGTTATTTCAACAAATTCTGGCTTTGGCCTAGCTTACAGCGACTTATCCACTGGGGAAACTTTTTCCACACACTTAACTGACTTTGAAGGTGTCGCAAATGAATTATTATCCCTTCAAACAAGAGAAGTTGTGTATAACGGTCATTTAACAGAAGCAAACAAGGACTTTTTAAAGAAAGCTAATATTACTGTTTCTGAACCGGTTAAAGTAGAGGGCGAACATGCTGAGATTTCCTATGTAACGCAAAATTTAACTGACGATGCAGAAATTAAGGCTACCAAGCAACTAGTAGCTTATTTGCTGTCGACGCAAAAGCGTAGTTTGGCTCACTTACAAGTAGCACAAAGTTATGAGCCTACGCAATACTTGCAAATGTCGCATACTGTGCAAACGAACTTAGAGTTGATTAAATCAGCTAAGACTTCTAAGAAGATGGGATCTTTATTCTGGCTCTTAGATAAAACAAGCACGGCAATGGGAGGCAGACTTCTTAAATCTTGGATTGAACGTCCGCTTTTATCAGTTACTGAAATTACTCGTCGTCAAGAAATGGTTCAAGCGCTTCTTGATGATTACTTCACCAGAGAAAAAGTTATCGACAGCTTAAAGGGTGTGTATGACTTAGAAAGATTAACTGGTCGAATTGCTTTTGGTTCAGTTAATGCTCGTGAAATGCTACAACTAGCGCATTCTTTAGGTGCAATTCCTGATATTTTGAATTCCTTGCTTGAAACAAATAATCCACATCTGCAAAACTTTGCTAAGCAAATTGATCCGTTAAAGGGAATTCATGATTTGATTGTTAACACTATTGTGGATAATCCACCACTTTTAACGACGGAAGGTGGCTTGATTAGGGAAGGAGTTTCAGACCAATTAGACCGCTACCGTGATGCCATGAACAACGGTAAAAAGTGGCTATCTGAAATGGAAAGTCACGAGCGTGAAGTAACTGGAATTAACAACTTAAAGGTTGGCTACAACAAGGTCTTTGGCTACTATATTGAAGTTACGAATTCCAATAAAGATAAGGTGCCAACTGATCGCTACACTAGAAAGCAAACATTAACTAATGCAGAGCGTTATATCACGCCTGATTTAAAGGAACATGAATCCTTAATTCTAGAAGCGGAAGCTAAGTCAACAGGCTTAGAGTATGACTTGTTTGTAAAATTAAGAGAAAATGTTAAAAAGTATATTCCAGCTTTACAAAAATTAGCTAAACAAGTTGCCAGTTTAGACGTTTTGACGAATTTTGCGACAGTTAGTGAACAAAATAATTATGTTCGTCCAGACTTTACGGTTGATAAGCAAGAAATTAATGTAGTTAATGGTCGCCACCCCGTTGTTGAACAAGTGATGACGGCTGGTAGTTATATTCCTAATGACGTGAAGATGGATCAAGATACCGATATTTTCTTAATTACTGGACCTAATATGTCTGGTAAGTCTACTTATATGCGTCAAATGGCCTTAATTGCAATCATGGCGCAGATTGGCTGTTTCGTTCCAGCAGATAGTGCAACGTTGCCAATTTTTGATCAAATCTTTACTCGAATTGGTGCAGCAGATGATTTGATTTCTGGTCAGAGTACTTTTATGGTAGAAATGAGCGAAGCTAATGACGCTTTGCAGCATGCGACAAAACGTTCTTTAGTTTTATTTGATGAAATTGGACGAGGTACTGCTACCTATGATGGGATGGCCTTAGCCGGAGCAATCGTGAAGTATCTTCATGATAAGGTCGGGGCAAAAACGCTCTTTGCGACTCACTACCACGAATTAACTGACTTAGACCAGACTTTAAAGCATTTAAAGAATATTCACGTTGGGGCAACCGAAGAAAATGGCAAGTTGATTTTCTTACATAAGATCCTACCAGGACCAGCAGATCAATCTTATGGTATTCACGTTGCTCAATTGGCAGGCTTACCGCATAAGGTTTTAAGAGAAGCAACTACGATGCTTAAGCGATTAGAGAAGCAAGGAGCAGGAGAGTTGCAGCCAGCTAGCGAGCAACTTGATCTCTTTACTGCTGAAGAAGCGAGTGTACCTGCAATTTCAGATGATGAAAAAGATGTCTTGGATGATATTCAAAATGTATATCTTGCTGACAAAACTCCTTTGCAGGTTATGGAACTTGTAGCTCAATGGCAGCAAGAGTTGAAAGATAAGGATTAATAATCATGAGCAAAATTCATGAACTTTCACCTGAATTAACTAATCAAATTGCTGCTGGTGAAGTTATTGAACGGCCAGCTAGTGTTGTTAAAGAATTATGTGAAAATTCCCTTGATGCCGGTAGCAGCCGCATTAGAATTAACTTTATTGATGCAGGCTTAAAGCAAATTACGGTGCAAGACAATGGGAGCGGAATTGCAAAAGACCAGCTTAATTTAGCTTTTACTCGGCATGCAACAAGTAAGATTGCAACAGAGCGAGATTTATTTAATATTTCTACTTTAGGCTTTCGCGGAGAGGCTTTAGCGTCAATTGCGGCCGTTTCTCATGTGGAAGTAATGACTAGTAGCGATAATTTAGGCGGAGTTCGGGCAATTTTTGTAGGTAGTGAAAAAAAGCTCCAAGAAGATGCTGCTTCACCAAAGGGAACCAAGATTTCAGTTAGTGATTTATTTTTTAATACGCCAGCTAGGCTGAAATATTTACGCTCTGAAAGAACTGAAACTCTAAAGATTGTCGATATTGTTAACCGACTTGCTTTAGGACATCCTGATGTTTCTTTTACTCTTACTAATAATGGTAAGATCTTATTAAAGACCAACGGACGTAATGATTTAAGACAAGATATTGCAAATATTTATGGCCGTCAACTTGCAGAAAAGATGGAGGTTTTGAAAGGAAGCAGTCCTGATTTTAAGATTACCGGCTTACTTTCTGATCCTAATACAACTCGTTCAAGTCGAAACTTTATTTCTTTATTATTGAATGGCCGTTATATAAGAAATTACCGTCTAACTCAGGCGATTATAGCTGGATATGGCAGTAAATTAAGACCACGCCGTTATCCAATTGCTGTTGTAAACATTGAGCTAGATCCACTTTTAGTGGATGTTAACGTCCATCCAACTAAACAAGAAGTGCGCTTGTCAAAGGAGCAGGAATTAGAGCGCCTGTTAACTACAAGTATTTCAGAAGCCTTAGATCAGAATAGTCAGATTGATTCAGGTTTGAATAATTTATTAACTCCTAAAAAGTCGACAAATATTGACCAATTAAAATTTAACTTAAATAAAGATGTGGTTGATACTGTTCGTCCAGTCGAATTTACTCCGCAAGTTGAAGCTGATAAAAGTGCTGAAGTTCATGAAACAGCGGCAAGTTTTGTTAGCTTAGATAAGGTTCGTAATGACGATAAATATGTGATTACTGCAACTTGGGATGAAAATGTGGATAAGCAGGTGCAGCTAAGTCCATTTGATGAGGAAAAAGATCTGCAAGGAAAAGATGATAGCATTATTTCTTCAGGGGATGAAATCTTAGCTAATAGCCTACCTGAATTAATTTATTTAGGTCAGACTAAATCATATTTAGTTGCACGTCATGATGAGGACTTATACTTAATTGATCAAGTAGCAGCTTATCGACGCTTAGCTTATGATCAAATTTTTCGTGATTTAAATAGTGAAAATATTTCTCAGCAAGGTTTACTTAGTCCTTTAATTTTAGATTTTAGTAATGTTGACTATTTGAAGTTAAAAGAAAATCTTAATAATTTACAAGAATTAGGGATATTTTTAGAGGATTTTGGTCAAAATAGTCTGATCTTAAGAACCTATCCAATTTGGCTCCAACCTGACGTAGAAAAAAATGTCCGCATGATTTTAGATTTATATTTAAATCAAAATGAACAAGATTTTACCAAGCTTAAAGCACAAATTGCTGGTGAAATAACGCTGCGTCAAAGTACTAGAAGAAGAAATCTAAATCCAGTTGAAGCACAAGAATTATTGAAAAATTTGAGAAATAGTAGTGATCCTTATCAAGATTTTGAGGGAAAAATTATTATTATTCAGTTAAGTGAAAATGATCTCAATAAGATGTTTAAAAAAGATGAGTAGGTAAAATGTTTGAATATCTCAAAGGAATAGTAGCAAAAATCGATCCAGCTTATGTAGTATTAGATGTAAATGGCATTGGGTATAAGATCCTTTGTCCCACTCCATATAGCTATCAAGAAAATCAGCCAGCAACTATCTATGTTGAACAAGTTGTTAGAGATACAGGGATTACCTTATATGGCTTTTTATCTTTAGAAGACAAAGAATTATTTTTAAAATTATTAAGCGTTTCAGGAATTGGACCAAAGTCAGCTGTGGCGATTATGGCGGCTGAGGATACAGATTCGTTAGCTAGCGCAATTCAGAATGGAGAGGTGAAATATCTAACTCGTTTTCCAGGGGTTGGAAAAAAGACTGCTTCTCAGATTGTCTTAGACTTAAAGGGAAAGTTAGGCGACTATGTAAAGAAATCAGCAGTTGCTACCGATCTTACACCGAGCCTGCAAGATGCTTTGCTTGCCTTGGTAGCACTTGGTTATACCCAAAAAGAAGTTGACCGAATTACTCCAAAGTTAGCAAAATTGCCTGAAAATACTGCTGATGGTTATATTAAAGAGGCTTTAGCTTTACTACTTAAGAAGTAAAAGTAAAAATTAGGTAAGGATAAGGAAGTGAAAGATGTGAATGATGAAGAACGAATTATAGGCGCTGAGAGTAATGAAGAGGATGAAACGATTGAATTGTCTTTGCGTCCGCAACTACTTGCTCAATATATTGGACAAGATAAAGTAAAGAGCGAGATGAAAATCTATATTAAAGCGGCTAAGCAGCGAGACGAAGCTTTAGATCATGTTTTGTTATATGGCCCACCTGGTTTAGGTAAAACTACTTTGGCATTTGTAATCGCTAATGAAATGGGCGTTCACTTAAAGAGCACCTCGGGTCCGGCAATTGAAAAGGCGGGCGATTTGGTGGCTCTGCTTTCGGAATTAAATCCAGGGGATGTCTTATTTATTGATGAGATTCACCGTTTAGCAAAGCCAGTCGAAGAAGTCTTATATTCGGCAATGGAAGATTTTTATATCGATATTGTGGTTGGAGAAGGACAAACAACTCATGCTGTACACGTGCCACTTCCTCCATTTACTTTGATTGGAGCAACTACCAGGGCTGGTCAATTATCTGCGCCGCTAAGAGATCGTTTTGGAATTATTGAGCACATGCAGTACTATTCTATTGATGATCTAGAAAAAATAATTCAAAGATCAAGCGTAGTCTTTAACACTAAAATTGATCCAGAAGCTGCTATTGAACTAGCTCGACGTTCTCGTGGAACGCCGCGTGTTGCTAACCGTTTACTTAAGCGGGTTCGCGATTTTGCGGAAGTAAAGGGAGAAGAAGCTATTTCTTTAGCAACTACTAAGCACTCACTTCATTTGTTAGAAGTTGACGATGAAGGTTTAGATCAAACTGACAGAAAACTTTTAAGAATGATGATTGAAAATTATGGTGGCGGTCCGGTCGGGATTAAGACTATTGCAGCTAATGTTGGTGAAGATACAGATACAATTGAAGAAGTTTATGAACCATATTTACTTCAAAAAGGATTCATTACTCGAACTCCTAGAGGGAGAAGCGTTACGCAAAAAGCTTATTTACAATTAGGATATCCACCAAAAAAAGCAGAGTAAGTTTTTAGTTGGACCAAAAATACGGTATAATTATTATTTGAAAGTTAATTAATAAAAATAATGAGGTGTAATACTTTGAATACATTTTTCTTAGCACAAAGTGCTGCTGGTATGAATAACATGTTCATGATTATTGCAATGATTGCAATTTTTGTCTTCTTCTACTTCTCCATGATCAAGCCGCAAAAGAAGCAACAACAAGAACGGATGAAGATGATGTCTGAACTTAAGAAGGGCGATCAAGTAATTATGGTTGATGGCCTTCATGGTAAAGTTGATTCAATCAATGACGCAGATAAGACTGTTGTGATTGATGCCGATGGAATTTTCTTAACATTTGAAAGAATGGCTATTCGTCGCGTTCTTCCAACTGCTGCCGCTCCTGCTAAAGATGTTGAAGCTAATGAAGCAAAAGAAGAAAAAGTTGAAACAGAAGAAAAGCCTACTGAAAGCAGTAAACCGGAAGAAACAGCTTCTGATAAAACTGATGATACTAATTCTGAAGATAAATAAAAAAACGTCCGCAAGGACGTTTTTATTTTTTCATTGTCATGGCTTAGTATTGTAAAATATGAATTGGTAAAGTAAATTTTAATAAGTTTAATAGGTAGGTAGTTAGAATGGAAAATATTCCAGTTGTCATGATTATTTTTGGTGGCTCGGGTGATTTAGCTCATAGAAAGCTTTATCCAGCCTTATTCAACTTATATCAAAAGGGATTAATTCATGATCATTTTGCCGTAATTGGTACAGCTAGAAGACCATGGAGTCATGAATACTTACAAGAACAAGTTGTTGAAGCAATTAAAGAAAGCAACAGCAGCTTTGATGAGAAAGATGCAAAAGAATTTGCTTCGCATTTTTATTACCAATCACATGATGTAACTGATGTTGATCACTACATTGCTCTAAAAGAATTAGCTACAAAGCTTGATAAGAAATATCACGCAGAAGGCAACCGTATTTTCTACATGGCAATGGCACCAAGATTTTTTGGCACAATTGCAACCCATATTAACGATCAAAAGCTAGTTGGGAGTGGTTTTAACCGCTTGGTAATTGAAAAGCCATTTGGTCATGATCTAGCTTCTGCTGAAAAATTAAATCAAGAAATTAGCGAAAGTTTTGCTGAAGATTCGGTATATCGAATTGACCATTATCTCGGCAAAGAGATGGTCCAAAATATTATGCCGCTTAGAATGACTAATCCAATTGTTAATAATATTTGGTGCAAGAAATACATTGCTAATATGCAAGTTACCCTTGCTGAAAGCTTAGGCGTTGGTACTCGTGGCGGATATTATGAGACTTCTGGTGCTTTACGCGATATGGTTCAAAATCATATTTTTCAAATTATTACCCTTTTAGCCATGCCAGAACCTAAAGCCTTAGATTCAGATCATATTCATGAAGCAAAGCAAGAACTACTCGATAGTTTGGTCATTCCGACTCCAGAAATGGTAAAGCAGCATTTCTCACGTGGTCAATATTTAGCAAGTGATGATGAAGTGGAGTATTTAAAGGCCGATCAAGTTGCTCCTGATTCTAAAGTAGAAACTTTTGTTGCTGGCGAAGTTAACTTCAAGAAGGGTCCCGTAGCTGGTGTTCCAATCTACTTTAGAACCGGTAAGAAGATGAAAGACAAAGTTTCTAGAATCGATATTGTACTCCACCACATGAATAATTTATACGGCAATGCACATTCAAATAATATTTCAATTATTATTGATCCAAGAAGCGAGATTTTCTTTACTATTAACGGAAAGAAGATTACTACTGAGGGCTTAAGAAGAGAAAATCTCAGCTATAAGTTCTCTAAGGAAGAAATGGCTCAAGTCCCAGATGGCTACGAAAGATTACTTCACGATGTCTTTGTAGCTGATCGTACAAACTTTACGCACTGGTCTGAATTAAAGCAATACTGGAAGTTTGTTGATGCGGTTGAAGCTGCATGGCAAGATGAAAATAAAGATATTAAGCAACTTGAGCAATATCCAAGTGGTGAATTTGGTACTGAATCGAGTAACCATATTTTTGAAAAAGATACTGAACACTGGATTTACCGTTAATGGATTTACTGCCTAAAAATAATACTAAGCGTAAGATTATTCATCTGGATATGGATGCTTTTTATGCGTCAGTAGAGATTCGTGACAATCCTGCTTTAAGAAATAAGGCTGTTTTAATTGGCGGCGATCCTAAGAAAAATAGGGGACACGGGGTTGTGGCAACTGCTAATTATGTGGCTCGTCAATATGGTGCTCATTCAGCTATGCCGACAGCTAAGGCAATTAGGTTAATTCCAGCAGAAAAACTGGTAATTATTCAACCACATTTTGAAAAGTATCGGGCTGTTTCAGCTGAAATTCATCGTTTAATGCATAAAATGACTGATCGAGTAGAATCGGTTGCCTTAGATGAAGCATACTTAGATGTAACTGAGAATAAACTTCATCTAGCTGATCCTGTTCGGATTGCGACTATACTTCAAGAGCAAATTTATCAAAAGGTTGGATTAACAAGCTCATTCGGCGTTTCTTACAATAAGTTCTTAGCCAAAATGGGATCTGAATATGCTAAACCCTTTGGCAGAACCGTAATTCGGCCTGAAACTGCACTTGATTTCTTGGCAAAACAAAAAATTGAAAAGTTCCCTGGAATCGGTCCTAAGACGCAAGAAAGATTAGCAGAGATGGGAGTCTACACTGGAGCTGACTTAATAAAAATTCCAACGGATGTGTTGATTAAGAAATTTAATCGCATGGGCTATTTGATCGCCCAACATGCACATGGCATCGACTTACGAGCGGTAGTTACTGATTCAGAAAGAAATCGAAAGTCGATTGGGATTGAGCGAACTTTTAATCAGAGTTTGTTTGATGAAAATGAAGCTTTAACTAGACTGCGAGCTTATAGCGGTGAACTTGAGAACCGGTTGAAAAAGCGACATTTTCTTGCTAATTGTGTTGTCTTAAAGATTCGCGATGCTAATTTTAAGACAATTACTAAAAGAAGAAAGCTAAAACAAGGCACGAATGATAAAATTGTTATTTACGACACTGGTCGTGTTTTGTTTGAAACAGAAAAAGGGATGCTCACAACTGGAGTACGTTTATTAGGTCTTACGGTAACCGATTTTGAAGAACATCCAGTTGAGAATTTATCGTTAGATATTTTTGAAAACAAGTAATGATAAAATAAATTTAGTAAACAACAAGGAGAAAAGATTAATGGCAACTTTTGATGAAATTTATGAAAAAATAAAAGAATACCCAACAATTATTTTGCACCGTCACACTAGTCCTGACCCAGATGCAATTGGTTCTCAAGCTGGTTTAGCAAGATCATTGAGATTAGCTTTTCCAGATAAAAAGATTCTTTGTGCTGGTGAAAATGACGAAGGTGACCTGATCTGGATTAATAAGATGGATGAAGTTACACCTGAAGATTATCAAGGTGCTTTAGTAATTACTACTGATACTGCTAATACTCCACGTATTTCTAACAAGAATTACGATAAGGGTGATTTTTTGATCAAGATTGACCACCACCCAGATGTAGATCCATATGCAGATATGAGCTATGTAGATCCAGACGCACCAGCTGCTTCAGAAATTGTTTTTGACTTTTTGAAAGCAGAGAACTTGCCAGTTACTAAGGAAGTTGCAGCAGCTTTATATGCAGGTATTGTTGGCGATACAGGTAGATTTATGTATCCTGAAACTTCAGCTCACACTTTTGACGTTGCAGCTGAATTAACTAAGACAGGAATTAACATTACTGATATTGCTAGAGAAATTGCGGATGTTACTTTTGATGAAGCAAAATTGCAAGCTTTAGCAATGGATAAGATGGAAATTAACCCAGTTGGAGCAGCTTACACAATTTTGATGCAAGACGATTTGAAGAAGATGGGCTTAACTGATGACCAAGCAAACGTTGCTGTTTCAACTCCAGGTCGGATTAAGGACGTGTTAGCTTGGAATGTATTTGTTGAAAAGCCAGATGGTACTTTCCGCGTTCATTATCGTTCAAAGGGTCCTGTAATTAACCATTTAGCTGAAAAACATGATGGTGGTGGCCATGCATTAGCATCTGGTGCCAATGCCAAGGATATGGATGAAGTAAAACAAGTCTTTGACGAAGTAGTAGAAGTAACAAAGAAGTACAATGAAGAACATGGCACAAACAAATAGCATATTTCAAAGTGAAAAGATTAGACCAGAATTGCGAGCTGGTCTAGAAAAAATTAATTTTAGCAAACCAACTAAGGTTCAAGCTGCAGTCATTCCGGCTCTTTTAAGTAATAAAAGTGTTGTGGTTCAAGCAGCAACTGGTTCAGGTAAGACTCATGCCTACCTGCTCCCACTTTTGAACATGATTGATGAAAATGCCCCAGTAACGCAAGCAGTAGTTACCGCGCCTAGCCGAGAGTTAGCAAATCAATTGTATAAGGTAGCGCGTCAATTAAGGGATGCGAGTGGTCTAAATATTTCCATTGAATATTTGGGCGGTGGTAATGATCGTAATCGTCAAATTGAAAAAGCTGAAAATAGAGCTCCACAATTAATTATTGCTACACCAGGTCGTTTACATGACTTTGCCTCAAAGAAAGTCATTAATTTAGATAACGTCAAAGCCTTCATTATTGATGAAGCAGACATGACGCTTGATATGGGCTTTTTAAGTCAAATGGATGAGATCATCTCTAAACTAGATAAAAAGGTCGTTTTAGGCGCTTTTTCAGCTACTATCCCAGTTAAGCTAGAGAACTTTCTCAGAAAGTATATGTCAAAGCCAGACTTTATTGTTATTGATAATCCAGCAATTATTGCTCCTACAATTCAAAATGACTTAATTGATGTTGGTTCAAGAGATAAAAAAGAAATTTTATATAAGCTCTTAACGATGGGACAACCATATTTGGCCTTAGTTTTTGCTAATACTAAAAAGACTGTCGACGAATTAACTAATTATCTTGAAGAACAAGGGCTTAAGGTGGCTAAGATCCACGGCGGGATTACTGAACGTGAGCGCAAGCGTATTATTCGCCAAGTTAGAGAAGGGCAGTACCAATATGTTGTAGCTAGTGATTTAGCCGCTAGAGGAATTGACGTACCAGGAGTTAGCTTAGTAGTTAACTATGAAATTCCTAAGGATCTTGAATTTGTCATTCACCGAATTGGGAGAACTGGTCGAAATGGGCTTGAAGGTCATGCAATTACCTTGATCTATGATGAAGAGATGCCTCAAATTGAAGACTTAGAAAAGCTAGGTATTCACTTTGACTTTAAAGAAATTAAAAATGGTGAATTAGTTGAAAGAACACACTACCATCGTCGTGATAATCGCCAAGCTCGGAGTCATAAGCTTGATAATCGCATGATTGGAATGGTTAAGAAGACTAAGAAAAAAGTAAAGCCTGGTTATAAGAAGAAAATTAAGCAAGCTATTCAAAAAGATCGCCAGCAAAAGCGTAAGATCGAAGAGCGTCATCAGATTAGAAAAGCTAAACGTAGACGTAAGCGTGAACGCGAACAAGCACGCGGTAATTTTGACAACTAGAAAATTTGTAGTAAAATAAATCACGTTTAGGACATATTACTGAAGTATTTTCTTCAAAGAGAGGGCCAGGCAGGTGAGAAGGTCTAGAAATACTTAGTAATGCTACCTAATTTAACTAAAGAATTAAATATTTAAAGAGGTAACAAACACTGTTGCAATCAAGGTGGTACCGCGCTGGGAGCGTCCTTGTTTTATGCAATAGTGTTTTTTTATTTGTAGGAGACTTTTTATGAAACAATTGACTAGTTCACAAGTACGTCAAATGTTCTTGGACTTTTTTAAAGAGCATGGCCACATGGTTATGCCAAGTGCATCATTAATTCCACAAGATGATCCAACCTTATTGTGGATTAACTCTGGTGTTGCTACGATGAAGAAATATTTTGATGGTTCTGTTGTGCCTAAGAATCACCGAATTACTTCTTCTCAAAAATCAATTAGAACTAATGATATTGAGAATGTTGGTAAAACTGCACGTCACCAAACTTTCTTTGAAATGCTTGGTAACTTCTCAGTTGGGGACTACTTTAAGAAAGAAGTTATCCCTTGGGCATGGGAATTTTTAACTAGTCCAAAATGGTTAGGCTTAGATCCAGATAAGCTTTATGTAACTGTTTACCCTAAGGATACAGAAGCATATCATATGTGGCATGATGTTGTTGGCTTACCGGAAGATCACATTGTGAAGTTAGAAGACAACTTCTGGGATATTGGTGAAGGTCCATGTGGTCCTGACTCAGAAATTTTCTATGATCGTGGTCAAGAAAATAACGATGTTGCGGAAGACGATCCTGAAAACTTCCCAGGTGGGGAAAATGCTCGCTACCTTGAAATTTGGAACATCGTCTTTTCACAATTCAATCACTTACCAAATGGTAAATATGTTGATCAACCACATAAAAACATTGATACCGGTATGGGATTAGAGCGTGTTGTTTCAATTATTCAAGATGCACCAACTAACTTTGAAACTGACTTATTTATGCCAATTATTAAAGAAACTGAAAAGCTAAGTGATGGCAAGAAGTATGCAGCAAACAAGGAAGATGACGTAGCATTTAAGATTATTGCTGACCACGTTCGTGCTGTAAGTTTTGCGATTGCTGATGGGGCTCTTCCTTCAAACTCAGGTCGTGGATATGTTTTACGTCGTTTAATTAGACGTGCTGACTTGAATGGTCAACGTTTGGGTATTAAGGGCGCATTTTTGTACAAATTAGTACCTGTAGTTGGCGAAATTATGAAGAGTCACTACCCAGAAGTTGTTGATCAACAAGCATTCATTCAAAAAGTAATTAAGAATGAAGAAGAAAGATTCCAAATAACGCTTTCATCTGGTTTGAACTTGCTTGATAATATTATTGCTGAAGCTAAGAAGAGCGATGATAAGACTGTTTCTGGTAAAGATGCGTTTAAGTTATTTGATACTTATGGCTTCCCATACGAATTAACTTTTGAAGCTGCTCAAGATGCAGGTCTTAAGGTTGATAAGAAGGGCTTTGATGAAGAAATGAAAGCCCAAAAGGAACGCGCACGTAAGGCTCGTGGTAACTTACAATCAATGGGTTCACAAGATGTTACTTTGATGAATATCAAAGACAAGAGTGAATTTGAGTACGGTACTTTAGAAGAAAAGCATGCTAAGTTAATCGATATTGTTGTTAATGATAAGTTAGTTGATAAAGCTGACGGTGAACACGCAACTTTAATTTTTGATAAGACTCCATTTTATGCAGAACGTGGTGGACAAGTTGCCGATCACGGTGAAATTTTGAATCAAAATGGTGAATTGGTTGCTCGTGTAACAGATGTACAACATGCACCAAACGATCAAAACCTACACTTTGTTGATATTATTTTGCCACTTGAAAAGGGACAAGAATATATCTTGAAAGTTGATCAAAAACGTCGTCGCGGCTTAAAGCACAACCATACTGCTACTCACTTATTGCATGCTGCTTTACGTGAAGTTTTGGGTACTCACACTCACCAAGCTGGATCTTTAGTTGAACCAGATTACTTACGTTTTGACTTTACTAGCTTAGAGCCAATGACTAAGAAGGAAATTGCTAACGTTGAAAAGATCGTTAACGAAAAGATTTGGGAAGAAATTCCAGTTAAGACAACAGTTACTGATCCAGATACTGGTTTGAAGATGGGTGCTTTAGCCTTATTTGGTGAAAAATATGGTGACACAGTTCGTGTTGTTCAAATTGATGACTTCTCAACTGAATTCTGTGGTGGTACCCACTGTGAAAACACTGACCAAATCGGAATGCTTAAGATTGTTTCTGAATCTGCTGTTGGTGCTGGTACTCGTAGAATTATTGCTGTTACTGGTCCAGAAGCTTACAAATATGTAACAGACCGTGACGAAATTTTGAAAGAAGTTCAAGATGAAGTTAAGGCAACTAAGGCTGAAGATGTAACTAACAAGATTTCTTCTCTTGAAGAAGACTTACGTGCAAGTCAAAAAGAAGCTGAACAATTAAAGGCACAAATTAACAAGGCTAAAGCCGGCGACTTGTTTAATGATGTTAAGCAAGTTAAAGGTTTAACTGTAATTGCTGCTCAAGCTGATGTAGAAGGCATGAATGATTTACGTGAACTTGCTGATAACTGGAAGAGCAGTGATAAATCTGATGTGTTAGTTTTAGCTGCTGAAGTTAATGGCAAAGCCAACATGGTTATTAGTTTGAACGATAAGGCAATTAAAGCGGGTCTTAAAGCCGGCGACTTAATTAAGACTGCTGCTCCAATCTTTGGTGGTGGCGGTGGCGGTCGTCCAAATATGGCACAAGCTGGTGGTAAGAACCCAGCAGGCTTAAAGGACGCTATTGCTAAAGTGTTACAAGAAGTTGAAGAAAAACAAAATTAATTGAGTTCGTTCGATATTTCAAGTAAAATTAAGAAGATAGGAGGAATTTTATTATGAGTTCGCTAGATAAAACGATGCATTTTGACTTTAACCAAAATAAGGGTAAGAATGTATACGATACTCTACAAGACGTATACAATGCACTTGAGGAAAAGGGCTACAGCCCAATTAATCAAATTGTTGGTTACTTACTCTCAGGCGACCCTGCATATATTCCTCGGCATAATGATGCCCGTAATTTAATCTTGAAACATGAACGTGATGAAATTATTGAGGAATTGGTTAAGAGTTATTTAGGTAAAAATAAATAATGCGATTACTTGGACTAGACGTTGGCTCTAAGACTGTGGGGGTTGCAATTAGCGATCCTTTGGGAATCACTGCTCAAGAGCTTGAAACAATCAAAATTGACGAGAGCAAGTTTAGTTTTGGCATGCGCCAAATCAGAAAGCTTGTCCGTAAATACGACGTCGAAGGTTTTGTTTTAGGGCTACCCAAAAACATGGATGGCAGTAGTGGACATTCTGTAGAAAGAAGCAAGCAGTACGGTGAACGCTTGAAAGAGAAGTTTGACTTGCCTGTTCATTATATGGATGAGCGGCTTACAACCGTACAGGCTGATCGTATTCTGGTTCAAGAAGCCGGCGTACATGATCGTGTTGAAAGAAAAAAAGTTATTGACCAAATGGCTGCTGTTTTGATTTTACAAAGTTATCTAGAAGCAACCAGAAAGGATAAGTAAAATGAGTGAAAAAATTAACGCTAACCAAGATAATGATCGTCAAATCACTTTAGTTGATGATCAAGGCAATGAAGAACTTTTTGAAATATTGTTCACTTTTACGTCTGAAGATTATGGTAAATCTTATGTTTTACTATATCCAGCAGCCGTTAGCGACGATGATGATGTCGAAGTACAAGCTTTTAGCTATGATGCAGATGAAGACGGTGATGTAACCAGTTCTGACTTACACGAAATCTCTGATGATGACGAGTGGAACATGGTACAAGGCGTTTTAAATACATTTTTGTCAGACGATCGCTTAAGTGGCGAATAATCTTCAAAAAAGACTGGCGCAGAAAGGCTAGTCTTTTTTGCTTAATAAGGATGAACAATGATTTCTATTCTCATTTTATTAATTTTTATTTATTGTTGTTATGTAGGTTATCGACGTGGCATAGTGTATGAAGGCTTAGCTGCAGGTGGATATGTAGTAGGGTTAATCTTGGCAACATTATTATATAAACCTTTTAGTAACTTCTTAAATCTTTGGGTGCCATATCCCTCAGCAAGTGATCGAAGTAGCTTTGCTTTCTTTGATAAGACTACAGGATTAACATTAGATAAGTCATTTTATGCAGCAATAGCTTTTTCAATTGTTTTGGTGCTTGTTTGCTGTATATGGCGTTTGGTGATGTTAGGTTTTAATCAGTTAAGATATGTTACTGTAGATGCTAGATTAAATACATGGGGCAGCATTATTATTGCTTTTATTGTGACCCAAATTAGTGTTTATTTGCTTTTATTTATCTTAGCTACGATTCCTAACAATAGTTTGCAAAATATGCTGGGGCATTCTATTTTAGCAAGTGGTATCTTGCATTTCTCTCCAGGAATTTCGCAAATTTTCATAAAATTATTCATTACAACAATATAAAAGTGGGCCCAGCTACGGGGCCCTTTTTGCTAGGTGGAAGATATGAACTCTAAAATTATTGAAAAATTAGAATATAATCGCATAATTAGACAATTAAGTGACTTGGCAATTACTGCACCTGCAAAAGCTCAGGCTCTGAAATTAATGCCAAGTAGTGACTTTGATGAAGTAAAAAAATCAATTGATCAAACTAGAGTACTTTCGAATATCTTGCGAGTTAAGGGGCCAATGCCGATAACTGACTTTAAAGATGTTCGACCTAGTTTGAAGCGATTGAAAGTTAAGGCTAACTTAAATGGTGAAGAATTAGGTAATATATTTCTAGTTCTTAGTTTGGCTAAAGATGTAGGACAATTTGCATCGGACCTTGAAGAGCGTGAAATTGATACACGTCCTATTGAAAAGTACCTCAAAAATTTAGCAGTTCCAGAAGATTTGTTTAAGAAGTTAAATCAAGCAATTGAATATGATGGAACAGTTAAAGATACAGCTTCTTCTAAATTGATGCAGCTTAGACATGATATTCAGAGTAATGAAACTGATATTAAGAACCACATGAATGACTATATTAGTGGCAAGCATACGCAATATTTGTCAGAAAATATTGTGACTATCAGAGATGGACGTTATGTTTTGCCAGTAAAACAAGAATATAAAAATAAATTTGGTGGAGTTGTTCATGATCAAAGTGCTAGTGGTCAAACTTTATTTGTTGAGCCACAAGCAGTCTTGGTACTTAATAACCGTCAACAAAATTTGCTGGCTCAAGAACGCCAAGAAATTCACCGTATTTTAATCGAGTTATCCGAACTTGCTGGTGCTTATCAAAAAGAAATTAATAATAATGCATTAGCATTAACTCAATTAGACTTTTTAAGTGCTAAAAGCAAATTAGCTAAGAAGATGAAAGCGACAGAGCCTGTCTTAAATCAAGATCATATCATTAAGTTGAGAAAGGCACGCCACCCCTTAATTGATCCTAAAAAGGTAGTACCAAATAATATTGAATTAGGAACTACTTTTGATACTATGCTAATTACAGGACCAAACACTGGTGGTAAAACTATTACCTTAAAAACTTTAGGATTGCTACAATTAATGGCTCAAGCTGGTTTATTTATCACAGCTGAAGAAGGTAGTCAATTAACGGTCTTTAATGAAATCTATGCTGATATTGGAGATGAACAATCCATTGAGCAATCTTTGAGTACATTTTCATCGCATATGGATCAGATTATTAAAATTATGAATAATGTTACTGAAGATGATTTAGTTTTAATTGATGAACTTGGTGCTGGAACTGATCCAGAAGAAGGTGCAAGTTTAGCAATTGCAATCTTAGATGATTTACGCCAAACACAAGCAAAGATTGCGATTACTACACACTATCCAGAATTAAAGTTATATGGTTATAACCGCAAGCGAACTACTAATGCCTCAATGGAATTTGACTTAAAGAAATTGGCACCAACTTATCGCTTGAGAATTGGAATTCCTGGTCAAAGTAATGCTTTTGCGATTGCACATCAATTAGGAATGAATGAAGCTGTTGTAGATAAGGCTAGGGACCTAATGAATGATGAAGACAGCGACATTAATAAAATGATTGAGCGTTTAACAGAACAAACTAAGGCAGCTGAACAACTTCATGAAACTTTGAAGCAAAATGTTGATCAAAGTATCACCCTTAAACGTCAACTGCAAAATGGGCTTGATTGGTATAACCAACAAGTACAAAAGCAACTCGAGAAGTCTCAGGAGAAAGCTGATGAAATGCTTGCTAAGAAACGTAAGCAAGCTGAAAAGATTATCAATGATCTTGAAGAGCAAAGAAGAGCTGGCGGACAAGTTAGAACCAATAAAGTAATTGAAGCTAAAGGCGCTTTGAATAAACTTGAGCGTGAAAATCAAAACTTGGCTAATAATAAGGTGCTACAGCGTGAAAAAAAGCGTCATGATGTAAGTGTAGGCGACAATGTTAAAGTCCTGTCATATGGTCAACAAGGTGTAATTACGAAGAAGTTAGGCGAGCATGAATTTGAAGTCCAAATTGGTATTTTGAAGGTGAAGGTAACTGATCGTGATGTTGAAAAGATCGCTGCACAAGCCAGTCAAAAAAAGCCAGAGAAATCTGTTCGCTCTAGTCGTGGTCTTCGTTCTAGCCGTGCAAGTAGTGAACTTGATTTAAGAGGGCAGCGTTATGAAGAAGCTTTGACTAACTTAGATCGCTATCTTGATGCTTCACTTTTGGCTGGGTTGAATACAGTAACCATCATTCATGGTATTGGTACAGGCGCAATTAGAAATGGTGTTCAACAATATTTAAAGCGTAATCGACATGTAAAGAGTTATAATTATGCTCCAGCTAATCAAGGTGGAACAGGGGCTACAATAGTTAATTTGCAATAAGCAATATACTTGCAAAAAGTAAGTAATTATACTAAACTATACTTATAATTTAAAGAATTTATTTTGTGAGGTAATAACTATGGTTGATGAAATTACAGATGCAACTTTTGAAGATGAAACTAGCGAAGGTGTTGTTTTAACTGATTTCTGGGCAACTTGGTGTGGTCCATGTAAAATGCAATCACCAGTAATTGACCAACTTTCAGAAGAAATGGACGATATAAAGTTCACTAAGATGGATGTTGACCAAAATCAAGAAACAGCTCGAAACTTAGGAATTATGGCAATTCCAACTTTACTGATTAAAAAAGATGGTAAAATTGTTGACCGCTTAACTGGTTATACTCCTAAGGAAAAGCTTGAACAAATCTTAGATCAATACACTGATTAATTTATAGTCAAAAAGGGTAAACCGCGATTGCGATTTACCCTTTTTGATATTAGTCTTTTTGTATTCATTAAGTTGATCAATCAGACTGAGCTGTAATTTGGACGACATGCTTTTTAGTAATCGTAGCTGAGGCCTCAGTAGGAGTGCCATTTTGGCGTTCTAAACATTCTGCAATAATTCCACTTTCCAATGAAAATTCATCACTTTGGCTATCTAGTCGATCAGTAACAACTTGTCCTGAAAGTTCGAAAACTGCAGTGTGTTTACGATCCTTGAGTACTTTTAAAGTTCCAAATTGAGCCATGTCAAAAAATTCGATCAAGTCATCGATGTCTGATAAGTCATATTTGCGACTGACGTGTTTACCGGCCCAGTAAAGAATTTCTTTATCTTCGCTACCTAAGATAGTAGGTAAGATAAAGTCACGGTATAATGAATTTAAAAAATAAAGATGTTCGTTTGTGTGTTCCATGCTTTCATTTCCTTTTGTCTTCTATAACATTTTAACTTAAAATAGGTGGAGGAGAAAAGAGATTTTAATCATCATTTGTTTAAAGGAGTTTTTTTAATGGATAATCGACCAATTGGAGTTTTAGATTCAGGCTTAGGTGGCTTAACTGTTTTAAAAAAAGTAATTGAGAAGATGCCTAACGAATCAACTATTTTTATTGGTGACCAGGCTAATATGCCCTATGGAGATCGCTCAAAAGAAGAGATTATTTCTTTAACTCGCGACAGTGTAAACTTCTTATTAAGTAAAGATGTAAAGATTATTATTTTTGGTTGCAATACTGCCACTGCGGTTGCAATGTCTACTATTAAAAAAGAAATTCCTTTGCAAATAATTGGAGTAGTTCAATCTGGTGCCTTAGCTGCAGCTAGAACCACAGAAACAAAGAATGTTGCGGTAATTGGTACTAAGGCAACTGTTAATAGTCATTCTTATTTAAAAGAAATTCAATATCGTGATCCAAAAATTCAAGTAAGCGAATTTGCACAACCTAAATTAGCGCCTCTTGCTGAGGAGGATCCTGCTGAAGAGATTAAGCAGGCTGTGGTCAGCGAAAGCTTAGCGCCGTTGAAAAAGGCTGATTACGATACCCTTGTTTTAGGATGCACCCATTATCCATTATTAAGAAAGGAAATTGTTGCAGTGGTTGGTCAAGATAGAAAGATTGTTGACCCAGCTGATCAGGTGGCACAATATACCTATAATGTTTTACGACGTGATGGTTTATTTGCGGCTGGTAATTCTGATACAAAACACGAATACTATACGACAGGTGAAGCTAAGAAGTTTACTGAAATAACACGTCAATGGATGAATGATGAAACAATTGTTGGTCATCATGTAGATGCTGAGGATTAAAAATGGATACTTTATTATTTGCAACTAACAATAAAAACAAGGCTAAGGAAGTTGAAGAAGCCTTAAAAAAGAATAACTTTCCGATTCATGTGATTACTAATCAAGATTTGACTGACCCACCACATGTGTTAGAAACTGGTACCACATTTTTAGCTAATGCCAAGCTCAAGGCTCACCAGATGGCAGAATTTAGCAATCTACCGACTTTAGCTGATGATTCAGGATTATCGGTCGATAAATTAAATGGTGCTCCTGGCGTTTATTCTGCGCGGTATGGCGGGGAAGCTCATAATGATGCTCTGAACAATGCTAAATTATTAGCAGAATTAGGCGGGGTGCCAAAAGAAGCGAGAAAGGCTACTTTTCATACAACGATGGTTGTTTCTTGGCCAGGTAAATTTGAGGATGATCTAGTAACTGAAGGCGAAATTCGTGGTGAAATTTTAACTTATCCACAAGGTGAAGGCAATTTTGGTTATGATCCGCTTTTCTTTGTTTCTGATAAAGGAAAAACATTTGCTGAAATGACGGTGGATGAAAAGAATGCAATTTCTCACCGAGGTCAAGCTTTGAGAAAATTACTTGCGGAACTACCGGCCTGGTGGAAAAAGATGGAAAACAAATAAATTTCGAAGAACTTATTCTGATTAGGGGATAAGTTCTTTTTGTTTTTTCTGCTTTTAATTATAAGTATGAAAGCGCTATACTAAAATTGTGAGTTTACTTAATAAATGTAAGTTTAATTGAAATTGAGGTTATAGCGTATGAAAAAAGTTTTAGCAATTAATTCAGGAAGCTCGTCCTTTAAATATAAATTATTTTCTTTTCCTGATGAAAAAGTTATCGCTTCAGGGATGGCTGATCGAGTTGGGATGGAAAATGCTGTCTTTAAAATTAAGTTGAGTAATGGGCGAGAATATATCAAAAATATGCCGATTCATGATCAAGAAGAGGCAGTGAAGCTTTTAATTGAGGATTTGAAAAAATTTCATGTAGTTGAAGATCTGAGAGAAATTACTGGAATTGGTCACCGAATTGTAAATGGCGGTGAAATATTTAAAGAATCAGTTCGTGTTGGTGACAAAGAGTTACAAGAAATATTTGATTTAGGTGAACTTGCGCCTTTGCACAACATTCCTGAGGCAAATGGAATTAAGGCCTTTATGAATATTGTTCCTAATGTTCCACAAGTAGCAGTTTTTGATACTTCATATCATCAAACTTTAGATCCAATTCACTATCTATATTCAATTCCTTATGAATATTATGAAGATTATGGAATTAGAAAATATGGTGCGCATGGAATTTCTATTTCTTATGTTGCACCGCGTGCAGCCAAGATGCTTAAGAAAAATCCTAACTTAGTTAACTTGATTGTTTGTCACTTAGGATCAGGTGCTTCAGTCACTGCGGTTAAACGCGGAAAGTCTTATGATACTTCAATGGGAATTAGTCCGTTAACTGGTGTAACAATGGGGACGAGAAGCGGAGATTTTGATCCTTCAGCACTTCAGCGTTTAATGCATAAGACCGGAATGAATATTGATGAAGCAATTGATGTTTTGAATTATAAGTCAGGTTTATTAGGTATTTCAGGTGTATCTTCTGATATGCGTGACTTAATTGAAAGTAAAGATAAGCGTGCCAAGTTAGCACGTAAGATATTCATTAACCGTGTTGTTCGCTATGTTGGTGCTTATGCAGCAGAGTTAGGTAGAATTGATGCAGTTGTCTTTACTGCAGGAGTAGGTGAACATGATCCTGGTATTAGAGCTGGTATTATGTCCTCATTAAGATATTTGGGGTTAGAACCAGATTTTAAGGCTAATCGAACAGATGGTGAAAAGTTTATTTCTAAACCTAAGTCTAGAGTAAAGGCAATTATTGTCCCAACTAATGAAGAATTAATGATTGCTCGCGAAGTAGTTCGCGTTGTGCAATAAAAAAGGATTAAGCAATAGATAAAAGTCTGGTTGCTTAATCCTTTAAGATGCAGAGCTATTTTCTTGTTTTGTTGGCATGGGACTGAATTTAAGCCCGCGTTGATTGAATTCTTTGATATAAGCACTGAGATAGGCATTTTTAATCGTACTTTGGCTATTTGCAATTACTTGAAAATGAATTTGATAGGTAATACTTGAGCCGGTTTGATTAATGATTCCAATAATTTGAGGGCCCTTTTTGATTTGTTTTTTAAACTTATCTTTTAAAGCGGCGTTTACCGTATCAACGGCATGATTAATTTCAGTAAGATTATTTTCTACTGAAAGATTTAAATTAATATCCATGCTCCAGCCAGAGTGTGAACCATGACTCAAATTTTCAACTACGGTAATGTTGCGATTAGGAATATAGATTACAGCGCCATTAGTAGTTTTAAGGCGGGTATTGCGCAAGGTAAAGGAGAGAACAGTTCCGGTGTAGTTGCCAATTTTGACAGTATCGCCGATATTGTATTCACCTTCGCTTAAGATGTTCATCCCAGTTATGACATCGCTAACTAAGCCTTGTGCGCCCATCCCTAAAGCTAGAGATACTAATCCTACACTAGCTAATAGCGTTCCGACTGGAATTCCCATTAACGTTAAAATACTATATAAATAAAATAAGAGAATAGTATATTGAAAAAGAGCAATTCCTAGTTGAGCTAAGGTTCTTTTTCTTCCAGTCATGCGTTCCTGAAATTTAGGATTTTTTAATAGGTATTTTGTTAATAAGCGCTTTCCTATATGCCAAATTAAAAAGAAAATAATTGTAGTAATAATAATTTGGATGCCACGGCTTAACAAAGTGTGCAGTACATTGTCCCAGTTAATTAGGTAATCGATATTATTAGTTTTTTTAGTTGTAGAAGTTCCTTTTAGAAGAGTAGACCAGTTCAACTCATGCCCTCCTTATCTAGTTTCTTTAAAAATAGTATATCAAAAACTTGGGTACTATTTCATTGCTTGAGGGGAGGAATAATGCTAGACTTTTTTATGAGAGGAATAATTAATGGAGGATAGATTATGTCAATTTCATATGGTGCATTAGCTGGCTTAATTGCAGCAGTTGCCTTTTTAATCTTGGTCTTATTTACTTTACCTTTGATTGTTAGAGTTACTAAGACAATGAAAAAAGTTGACTCAACTATGGACAGCGTTAATACGGCTGTTGATGATTTAACGAAACAAACTTCTGTATTAATGAAGCAAAGTGAAGATTTATTAGAAAAAAGTAATGCTCTTTTAGCTGACGTAAATGGAAAAGTAACAGAATTAGAACCAGTTGTAAAGGCAGCAGCAGATTTAGGTGAAAGCGTGTCAGATATCAATTCTTCATCAAGAAGAATGGTTGAACGCTTCTCTGGTATGGGTATTAGAGGAGCTGGAATTGGCATCTTTTCATCTCTAGTTAGTCGCATGTTTGCAAGACGTAAACGTCGTCGCGGTGAAGACTAATATTTATTAAAGGAGAACAATTATGCGTAAACTTGGTGGATTTTTATTAGGTAGCGTTGTTGGTTTAGGTGTTGGCTTAATTGCTGGCTCATTATTGTTGCCAGAAGACGCAACTGACGATGTAAAGAAAAAACTTGCTGAAAATGAAAAATTGCAAGATTTGAAAGAAAAGTATGATAAAGGAACTGAAGCTATTAAGAATCAATTAGCTTCTTTCCCTAAGTCAGTTGAAGATGATTCCGAATTAAGAGATTTTGATGATATCGTAATTGATGACACTAACAAAGATCTTGGCGAAGATGAAAAATCTGACAAGGATGCTGTTAGCGATTTAAACAATGCTGAAGATACTGAAAATAACTAAAATTAAATATTTATAAAGAGAATCAAGTTCTACTTGGTTCTTTTTTTGCAATAAAAAACCTGTTGATAAAATTTATCAACAGGTAATTTTAGGCCTAGTCTTTAACTGGAATATATTTTAATTCCTTGCTTGTCTTAGTGAAGGTTTCAAAACCGTTTTTAGTGACTACACCACAATCTTCAATTCTAACTCCAGCTACGTTAGGGATATAAATACCAGGTTCAATTGAGAAGCACATGCCTTCCTCGAGAACTACGTCGTTTCCTTCCATGATTTGTGGAAATTCGTGAACGTTCATTCCAATACCGTGGCCAAGACGATGAATGAAGTATTCACCATAACCAGCCTTAGTGATAATATTTCTAGCAACAGCATCTAATTCGCTAGCAGTAATGCCTGGTTTAGCTGCTTCAATAGCTGCTTGTTGCGCCTCACGGTCGACTTCATAAATTTCTTTTTCTTTAGCAGTTGGTTCGCCGTAAGCGACAGTTCTACTTGAGTCAGAAGCATAGCCGTTGTGCATGGTTCCAAGATCGAATAAAACTAATTCGTTTGGTTCAATTTTGTTCATTGTTGGACCAAGGTGAGGGTTAGCAGCATTTGTACCAGCTTGGACAATTGTCTCAAAACTAGTGTGCATTACACCTTTTTGAAGCTTTAGTTGGTAATCAATTTGTCCAGCAACATAACGCTCAGTTACGCCGTTTCTTAGGGCATTAAAACCAATTTGAAAGGCAAAATCAGCTTCTGCACCAGCAGCCTTTAATTGTTCCACCTCTTCTGGAGTTTTACGTAAACGTGCTTCAGCTACGAATGGAGAAACATTATTGGTAAATGAAGAATCAGGAAAGGCAATGCGTAATTGTTCTAAACGGTCAACTGAAAGATGCGATTTTTCGATTGCAATATTATTTGGTTTACCAACACGTTGATTTACTAAATCAGCAATTTTTGCCCATGGGTTTTCATGGTCAAGATAGCCATAAACATCGCCATCCCAAGCAGAGTTTTTAGCTTCTTCAACATTTAATTCAGGTGCAAAAATAAATGCAGGCTTGTCTTTAAAAGCAATTAAAGCAAAAATTCTCTCATGTGGATCCATGCTATAGCCGGTGAAATAATTAATACTGATTGGATCAGAAATATAAGCAACATCATTATTGGTTGAAATTAACCAATTTTGTAACTTGTCTAAGTTCATAATTTTGGCTCCTTTTTTAATATATACTGGGAGTATACCATATAATATGGTAAAATAATGAGTTTTTAGTCGTAAACGGTTGCAATGTGTGAATATTCTTGATAAGTTATAAAAGAGTGTTTTTACAGGAGTGTGAGAAATTTATGCAAAAGCAAGAAGTAACAATTTATGATGTTGCTCGTGAAGCAAAAGTTTCTATGGCTACTGTTTCAAGAGTAGTAAATGGAAATAATAATGTACGTAAAGAAACACGTGAAAAAGTATTAGCTGTCATTGATCGTTTGCATTATCAACCTAATGCAGTTGCTCAAGGATTAGCTTCAAAGAGAACTACAACAGTTGGATTGATTGTCCCTGATTTGACAAATATGCACTTTGCTGAATTATCTAAGGGAATTGACGATATTGCTACAATGTATAAGTACAATATCTTACTTTCAAGTGTCGGAAATACCTTGTTAAATGAAGATCAAGTTATCCAAAATTTACTTAATAAGCAAGTTGATGGTGTAATTTACATGTCAAACTTGATGAATGAAAAGGCACAAGAAATTTTCAATCGCACTAACACACCAGTTGTTTTAGCTGGTACTGCTGATGCTAACCAAGAATTTTCTAGTGTAACTATTGACTATAAGGCTGTTGAAAAGGAAGCTTTAGGTCTTCTATTAAAAAATGGTAAGAAGAACTTGGCCTTAGTCGTAGGTGACGGAAAAGCTTATGTTAACAAGGACAACCGTTTCGTTGCCTATAAGGATTTCATGGAAGAACATAATTTAAAGAACGTTCACATCTATGAAGATGCCAAGACTTATGAAGATGGCTATGAATTATTTAAGCAAATCAAAGCTGATAATGTAGATGGAATTATTGCTACTCGTGATGTAACAGCTGCAGGTATCGTTAATGCTGCTGCTGATGCTGGTGTAAAGATCCCAGAAGATTTAGAAATTATCTCCGCTGCTTCAACTAATGTCGCTAAAATTGTTCGTCCTCAATTAACAACTGTTCAACAACCGCTTTATGATATTGGTGCTGTTGCAATGAGAATGTTAACTAAGTTGATGAATGATGAAGAATTAGACGATTCACATGTTATCTTGCCATATACTTTGAAGAAGTCTCGTTCTACTAAGTAGATCTAACTATAGAAAATCCCTTTAGGTAATTTACCTAAAGGGATTTTTTAATATATAATTTTAATTTTTCTACGGAGCAGTCGGACCACTATCAGTGGCTGTATTGCCTTCACTAGTTTCGCTGCCAGTATTTGTATTAGCAGCTGAACCTTCATTAGAACTAATATTTGAATTTACATCATTTGCGGCATTGTTGCTCTCGGAATTACTATTTTCAGTTGAAGAAGATGATTCACTTGTGGAACTTGCACGACTCCGTCTGGTAGAAGTAGATGAAGAAGAACCATTACCATTTCCGCCTTGACCAGTACTTCGAGCTTGCTGATCATTAGCTCCGACAGTCCGATTAGTCGAAGATGAGGAATTATTATTTGATTCACGATATACTTCGTGGTTTTTACCATAGTAATTTTTAGCATCTTCTGAAGTTGAGACATCAGCTACAGCAAACAGACTGTTGATATTTTTCTTCTTAGAAATTGTCTTACCAGTGTAGATTAAGACTTTACCATAATCATTATTCTTGCCTTCTAAGTAGTCGTAGAAGAGGTTGTAGTCTTTAGTTGATCCACCGATACCAAATCTTGCAGTAGCAGCTGGAGCAGGGGATAAACTTAATGCGGTAGTCTTTTTACCAGAAAGTTCAATATTATCGCCATCATAGCTTACAGTTCCTGGCAATGTTCCAGTTCTTGCTAAGACTTTATTTTTATAAACAGAGCTTGGACGACTTGGTGCATCATTTAACTTAAAGATTGACGGATCTTCTTCGTAAAGTGCATTGGCGATATTTGCCCAAAGGTTTAAGTTGGTTTCACTGGAATTAGAATCTAGGTTATATGAGTGACCATAGAAGTTGTCATACCCCATCCAACTAGAAATTGTGATTCCAGGAGTAGACCCATTGAACCAAATATCACGATAATCATTACTGGTTCCAGTTTTACCGATTAAGTTCTTGTAGTTAAACTTCAAAGTACCAGTTAAGCTTGAAGCAGTACCCTTAGTTACTACTTGGTGAAGCATCTTTTGCATGATGTAAGAGGTGCCGGTAGAGAAGACTTTTTGTGGATTTTGTTTATGCTTATAAATTACTCTACCTGATGGATCTTGAATTTCTTCAATGTAGTAAGGATCAGCTCGCTTACCATTGTTATAGAAGTTAGAGAAGGCACTAGCGTTATCAGCAACTGAAAAACCATAATCTGTACCACCGAGGGCCAAACCTAGGTTTTCAAATTCGCTTTTACTCAAGTTTAAGCCTAGTTTTTTCATATCCTGACGTAAATTAATGTTCTTATCGTTGACTAATTTATTGTATAAGTTTACAGCAGGTAAGTTATAAGATTTACTTAGAGCTTCTTGAGCTAAGATAAACCGGTTTTCAACAGTGGAATTGTAGTCAGTTGGAATATAGTTGCCAAATCTAGTAGGGAAGTCTGCTAATGCTGTTTGACTAGAAATAAACCTGTGTTCAATTGCTGGACCATAAACTAGATATGGCTTAATAGATGAACCAGGTGAACGATAAGTATCAAAGGCGTGATTAATTTGAGAGTTCTTAAAGTCAACTCCGCCGCTAAAAGCTAATACCTTGCCAGTTGCATTATCAATTACAACACTACCGTTTTCCACATGCTCGGTAGTATTAACCCACTTGTTAGTAGATGAATCAAAATCACGAGAAGTCTTATCTTGACCATATTTATTTTGCTTAACTATGCGTTGCATAGTTTGATAAAGTGGCTGTCTAATCGTGGTCTTAATATGATAGCCCTTTTGATGAAGCAGTTCAGTTGCACTAGTTAAGTATTGATTATAACGATTAGTATCTTGTTTAACATCTGATACCTTTAAACCATCTTGCTCAATTAATTTTTCTGCTAAAAGACTAGTACTCTTATTCATTACTAAATTATATAAGTAGCCACTTTGTTTCTTTTGTTTAGATGCTTTTTCAGGAGCAAGGAAGTCAGCACGTAAATCATATTTTTTAGCTGCAAGATAGTCTTTTTTACTGATATCGCCGTTTCGATACATCCGAAATAGAACAATATCTTTTCTACGCATCGCTAAATCAAGGTCTTTTTTAATTTTTCCGTTTAAACGATATGGGGTATAAACAGATGGACTTTGAGGTAAACCAGCAATAAAGGCAGCTTGAGGAAGGTTAAGTTCAGAAATAGACTTACCAAATATCCCTTGAGCTGCAGTTTTAATACCTACGATGTTTTCTCCACGGTTGTTTTTACCATAAGGAGCAGCATTTAGATATGAACGGAGAATATCTTCTTTTGAGAAATGCTTTTCAATCTTATGAGCATAAAACATTTCGGTAACTTTTCTTCTCCAAGTGGTCTGACTAGTTAAAAACTGCATTTTAACTAATTGCTGAGTTAAAGTCGATCCACCAGTTTGTACACCAACACCAGTTAGCTCAGAAAGAACAGCTCTAACTAGGGATTTAGGTAAAACCCCTTTATGAATATAGAAATTTTCATCTTCAGTAGCTGTCACAGCATTCTTAACTAAAGGAGTTAGTTCGCTTTCACTTGCCTTTTTAGTGACGGTATCTGGACGAACTGTAGCAATTTTTTTATTGCCAGCATAGTAAAGTGTGGCTGAATTTTGTGCATGGTTTATTTGCTGATTTAATTCGCTAATTGTTGGAATGGGCTGCTGGCGAACGATGCCAAGAGCATAACCACCACCAAAACCGATTAGGAGAAACAAACCAAAAACTGCAATTAAGATCAAATAATGAAAAACACGACGTAAAGTTAAATAAACGATGCCACTGTAAAATTTCCATTGGCTTTCGTCTGATTTGCTTTGAAGTGTTTTAACTTCTGGCCCCGCAGTTAGGAACTCTATGATTTTTTCTTTTAAATTTTTCACAGATCAGGATCCTTTGTTAGTTACTTTCCCCCTATTATAGCAAAAAAAGGACTAGCAATGACGCTGTCCTTTTTTACGAATTTATTAATATTTTGATTTATTTAGTTAATTCATAGATTGCTTCGGCATAAATAGCAATTGAATTAATTAAATCGTCAACCTTCATGTATTCATTTGGTTGGTGCATAACAAGTGGAGCACCTTCTGGTTGAGCACCAAAGGCTACACCATGTTTGAATAAACGGCCATATGTTCCGCCACCAATGATAACTTCGTGACCTTTCTTACCAGTTTGCTTTTCATAAACTGAAAGCAGGGTCTTAACAATTGGATCGTCTCCAGGAACGTAATGAGGAGCTTCTGCTGAACCATCAATTCTGGCGTCTAAGATATCGCCGAATTTTTCGTTAATATTTTTAACCATTTCTTCTGGCTCAATACCTTGTGGGTAGCGAACATTGTTTAATAGGTATGCGTTTTGACCTTCAAAGTTAAACATACTTGGTGAACTAGTTAGGTCGCCCATTAAGTCGTCATGATGGAAAATACCTAATTTCTTACCGTTAAAGTCTTTGTGTTCAACAGTTGCAAGGAAGTGTAAGAAATTCTTCGCTTGACCGTCAAAGTTAAGGCTATCAAGGAAGAGAGCAAGGTAAGTAGCAGCATTTCTACCAGTTTCAGGAGCAGAAGCATGAGCACCATGACCGGTTAAAGTTAATGAAAGACGGCCGCTAAGCATTTCTGCCTTTCCTTCAAGCTTATGCTCTTTCAGGAATAAGTTGAACTTTTCTTTGATGCCATCGATATCGCCTTCAAGTTGAGCATGAGCTGTTTGAGGGATAACATTAGTTGCAATTCCTGATTGGAATGTCCAAAGTTTAACATCGCCTTGGCTTGGGTCATCTTTAAAGTCAAGTTTTAAGGTAACAATGCCTTGTTCACCATTGATAATTGGAAATTCTGCGTCAGGAGAGAAAGCAACATCTGGAGCTGGTTGATGCTTTAAGTAATAGTCAATTCCAACCCAGTTAGTTTCTTCATTAGTTCCAACTACGAAGTCAATTTTCTTTTTAGGTTTAAAGCCATGCTCTTTTAAAATCAGCATGCCATAGTAAGCTGCTAAGGATGGGCCTTTATCATCAGCACTACCACGCCCATAAATTTTGCCATCTTTAATAGTCATCTTAAATGGATCAGTTTTCCAGCCTTCGCCAGCAGGAACGACATCCATGTGGCCGATAATACCAACGCGTTTGTCGCCAGAACCCATGTTGATTCGACCAGCATAGTTATCAAAGTTTTCAGTATCAAAGCCGTCACGTTTAGCAAATGATAAAAACTTCTTCATAGCCTTCACTGGGCCAGGACCTACAGGATATTCTTTGCTAGTATTGTTTAAATCTTCAGAAGAATCAATTGCAATCAATTCTTTTAAATCATTTAAAATAGCATCTTTCTTTTCTTGTGCTAATTTTTTATAATTTAGTTCTTCCATAACGTACTCCTTTAATTTTTATCTCTGATTAAATATTACAGCATTTACATCTGAATAAGTCGACCAAAAGCTTTTATTTGGGACTTTTTCAACTGGTAAATAAGGAAATAGGGCAACGTTTGTTTGACGAAAAGCAGGATCGAGTTTTCGATAATTCTTATAGGCAAATGTGTTTTTATTAAATAAGCCATAATATAAGACTTTAGACGACTTAACCCAGCCATCATCAGTAAGAAGCCATAAATCTTTAACTCCGCCACTTACACCTAGTATTTTATAGTGTTTTCTTGGCATAAGTTGATTCTTTTTACCAGATTGCTTATCAGGTTTATTATAAGTGAAAATTGGATTTTGAGTAGGGTTAATAATACTTAAATTCCAATATGGTAAAATCCATTCAGGTTGTAGGTCCAAACTAACAAGGTCAGCGGGAACAAATTCCTTATCGCCAATTTGGTAAAAAGTCTGTCCTGAAGCAATAACAGCTGAAGAAACATGAACTGGGTCTAAAAAATTAAGTTCTTTTGATGTTGTCACCTTTAGATATGGATTCTCACTAATTGTAGTAGGTACACGGCCAAAGTAAATTCCGTCCTTGTTAACGACATATTTTTTAGTGCCAGTTTTAGCTAATTTGTATTTATAGCCTCTTGCGGGGAAATTAGTGACAACTCCATCAACATCATTGTTGATTAACCAATTCCATAACTTAGGCGACTCATTCATTTCGGCCCAAACAAATACCTTTTGATGTAGCGCGTGAAGTTGACTAATTAGCTTGGGATTTTGGGTAACTAGATCAGATGAGATATTGATTCCGTTTACGTAACTTAGTACTTCAAAATTAATTCTTTGCAAAGAACCAACAATAAAGATTCTTGGAACATCTGGTAACAGTTGACTCATAGTTTTTAAACTTGGTGCAGAAAAGCTGTGAATCATTACTCGATCTTGCATATGGTATTTCTTGATACTGGCAGCAAGGAGTTCTTCCATATTTTTAGGACTATTATGCTTAGTTTTTTTTGTTTCAAGCAAAAATTTAGTGTTAGGTTTATCTTTGTAGTAATCAAATAATTGATCTAAAGAAATAATTGATTCACCATTAGCTTGTTTTAAGGTGTTTAAATAGGAAAAATTATTTTGTGATACAATAACCGATGATCCAACAACTCTGCTTAGATCGCGGTCATGAGAAACAACTAAGACGTTATCTTTGGAAACATGCAGGTCGAGCTCTACATAGTCCGCGCCATCTGCAAAAGCTGAGTTATCACTTTGAATTGTTTCTTCTGGATATTTACTGGGATTACCGCGGTGACCAATGACTAGGAATCCCGATTCAAAAATAAAAATCAAACTAAAAAAAAGGGCTAGGAAATAAAGCCTGCTTGTTTTCATGTGTACACCTCTATTCTTTTTAACAATAGCATGGATGTATACTTTTTTCTATAATTAATATAGTAGTTAATAATCATTTTTAAGAAAGTAGATGCTGCAATATGGCTTATGAGCAACTAGATTTAATCGAAGAAGTTACTCGCAATGATGGATCTAAATATTATGAAATTTCAAATATTGATCAAAATGGTATCGCTGAATTAGCCGTAGATCGTGGATTGATAAAGAAGGTGCGGATACTTCAGCTAAATTTGGCTAGAACAAAAGCACTTCAATTATATGAAGAATATATTAATAAAACGTACCAACTAGAGACTTTAACCAATGAGGATGATTGGAAAGATCCGCAGTGGGTTGAGTGGGAAAAGCCTAAAGGAAAAGTTTTAGACGCCTTTAATACAGTATTAAAAGCCAATCATATTGGTTAGAAGAGAGTAAAGTATGGAAAAATTACGTATTGTTCATACCAATGACCTACATTCTCACTTTGAACAATTTCCTAAAATAAAAAGATATTTACATCAAGCACAAAATGACAAAAGTGTTGATCAAACTTTTACCTTCGATGCTGGAGACTTTATGGATCGTTCTCATCCCTTATCTGATGCAACTGAGGGCCAAGCTAATATTAAGCTGATGAATGAATTTAACTATGATGCGATCACAATTGGTAATAATGAAGGAATCTCTAATTCACATGCAGTTTTAGAAAAATTATTTGATCATGCGAATTTTCCAGTTATTTTAGCTAACTTACGTGAAGAAGATGAAAGTATGCCTAAATGGTGTACTTCATATAAGATTTTTGAAACTAAGAAGAAAACGAGAATTGCAGTTGTTGGCTTAACTGCTGCATATCCTATGACCTATGGTCCTAACCACTGGCATGTGAAGTTGATTTCTGATACTTTAGATAAGTTACTTCCTACAATTAACGGGCAATATGATATGTTAATTATCGTTAGTCATATTGGCTTAAGAATGGATCGGTATATTGCACATCATTATCCAGAAGTGGATTTGATTGTTGGTGGGCATAGTCATGATTATTTACCAAAGGGCGAGAAAGTAAATAAAACATGGATTACCCAAACTGGAAAATGGGGTCAGCATATCGGCGATATTGCGATTCAATTAAATGATGATCACCAGGTAGTGTCAATTGTACCAAATACTGTCAAAACCGCTGATTTACCAAGTTCGGAATCTGATCAAGCTAAAATCGATGCTTGGCGTAAGCAGGGTGAACAAATGCTGCAATCACGTCAAATTGCAAAGTTACCTGCTAAATTTAACGATGATAAAATGGCAGCAATTCAAGTTTCTCTAGATGCAATTAGTGATTTTGCTGGAACTGATATTGCGGTTTTAAATAGTGGCTTATTTTTGACGCCATTTCATCAGGGAATTTTAACAGAAGCTGATTTACAAGCTGCTTTACCTCACCCAATGCATGTAGTGCAAACTAAATTATTTGGAAGTGATGTTTGGCGCATGGTAATGGAGATGGAAAAGAACCGTCATTTTCTAAGCAAGTTTGCCCTCAAAGGAATGAGTTTTAGAGGGAAAATTTTTGGCGATCTTGTTTATAAAGGCATTCAGGTTGATCATGCAAGTAGAACAGTCTACATTAACGGAAAAGAGATTGATCCTGAAAAAGAGTATACAATTGCCTTGCTTGATCATTATGTTTTAATTCCATTTTTCCCTACCATTTCAATTATGGGTAAAAACAAGTTTTTATTCCCTGATTATTTACGAACTGTAATTGGAAACTACTTAAAAGAGAAATATCCAATAGATAAATAGAAAGAAAAATAATGGAGTATAAAGAAGCAGATAAAGAACAACCGCTTTATCATCCTTTGGCTCATGTAATCGTTAATGAAGATAAGATAATGATTAATGGGCGAAAGTATGAAATTTTAGCTAATGTAAAAGATGCTCTAGATATTGAAATGCTAAAAGAGAAATATGATCCTTTCCTTGACCAGTACGATTATTTAGTAGGGGACATTTCAAGTGAGCATTTAAGATTAAAAGGATTTTACGATGAAAAAGATCGCGTTGCAATTGATAAAAAAGCTAATGCGATTGTGGATTATTTAGAGGAATATTGTAATCCTGGCAGTGCATATTTTGTTTTACGACTAGCTCAAGAAAATCAGATTAAAAAGGTTGCATTTGGCAGACAAAATAAGAGAAAAAATATGTCTAATAATCGCTATCATTCTAAACGTCCCTACTTTAAAGAAAGACGTGTCCACAAAACAAGAATTGGTGGCCATAAGACAGCTGTAAAATTTCAACGTGGAAAAGGAAGTCACAAGAATAAAGGCTTCGTAATTAAGAAAAGAAAGGGCTAATTGTGGAACATAAAGATTATAAATGTTACTTAATTGATTTGGATGGGACTATTTATCGCGGTAGCGATACGATCGAAAGTGGCGTTAGATTCATTCATCGTTTGCAAGAGAAAAATATTCCCCACTTATTTTTAACTAATAATTCTACTCGTACGCCGCGAATGGTAGTTGATAAATTGCGCGGACATGGGGTTAACACAGATATCTATCATATTTATACGCCGGTTTTAGCTACGGAGTCTTACTTGCTTGCTCAAAATCCAGATACTGCTAAGATACCAGTTTATATCATTGGACAGACAGGATTAGTGCAAGGTCTGTTAAAAAATGAACGTTTCTACTACGATGATCGAAATCCTAAATATGTTGTAGTTGGAATGGATACGGATTTAACTTATCATAAAATTCGCGTTGCTACTCGCTCAATTAGAAATGGCGCAACTTTTATTGGAACAAATGCTGATAAAAATTTGCCTTCTGGGGATGAGCTATTGCCTGGTAACGGTGCACTATGTACAATGCTAGAAGTAGCAACAGGTGTTAAGCCCATTTATATTGGTAAACCTTCATCAATTATTGTGGCTAGTGCTTTGAAGATGCTAAATGCTCAAGGCAGGGATGCAATTTTGGTTGGGGATAACTATGATACTGATATTATGGCAGGCATTAACTGTAATATTGACTCTTTGTTAACTTTGACCGGTGTAACTACTAAGAAGCAATTGGCAGAAAGAGATAAGCAGCCAACTTACGTTGTAGAAAATCTGGATGAGTGGAAACTATGAAGAAGAAACCAATCGTCGCCGTTGTTTACAATTGTTTGATGGCTCTTGCTACTGCTACTTTAGGTGCAGTAGTTTTAAGTTGGCCATTATTAGCAGTTTTTGTAAAAATTCAAAAAACGAATTTGATCGTAAAGACAACCTTAGCAAAACTATACACAACTCTTAGATTATTTATTGTCGCCATTTAATGATAGACTTCAGATGTCAAATTTCCCGACTTCTCCAAGTGCAGCGCGACATTTTTATGAGTGTAAGTTACTATTTGAATTAGCGATAATTGTTTTTGTAGTTGGATTAATTATTCTTATTTTCTTAAAAATGAGAAAAAGAATGAATTATATTTATATTTCGAGAACAACAGCGCTAATTTTCATGATTTTGCCTGTGATTATCTTACCGTTTGCTTTAATGAATTTTGATGAATTTTTTGTAGCATTTCATCATCTATTGTTCAACAATGGGGATTGGCTATTTAACCCTGCGACAGACCCAATTATTAATGTATTAACCGAAGAGTTTTTTGCTGGTTGCTTTGCAACTGGCGGAATAATTTATGAGTTATATTTTTCTTGTTTTATTTTGTCAAAAAAATAAAGGAGCTTTAACGAAGCTCCTTTTTTAATACTAATTTTTTCTTTAACCATATAATCAAGACTGGTAAAACTGAAATTAAAATGATTGCAATCACGATCAATGAGAAATGTTCCTGGACGATTGGAATATTTCCAAAGAAGAATCCTAATGCGGAAAATAAGGTTACCCAGAGAAAACCACCAATGAAGTTATAAATGATGAAAGTTCGATAATGCATCTTACTTGCACCTGATACAAATGGAACGAATGTACGAATAAATGGAATAAATCTTCCGATTACAATTGTAATACCGCCGTGTCGATCGAAGAAGTTTTCAGCGGCTTTTCGTTTATCTTGATTAATTAACTTGTTGAACCAACTGTGTTTAGTCCCTTCAGCTTGTGACCAATGTCCGATTTCATAGTTAATCGTATCACCTAAAACAGCAGCTGCTATGAAGATTAAATAGCAAACCCAGAAGTGAAGATTATATTTGGGCGTTGCTGCCATAGCACAACATGCAAATATAAGTGAATCTCCAGGTAGAAATGGAAAGATAACCAGACCTGTTTCGATAAAAATAATTGCAAATAAGATTAAGTAAGTCCAGTTTCCAAACATATTCACAATGGTGACTAAATGGTCATCAATATGAAGAATAAAATCGATAAGTCCCATAAATAAAAATAGATTCCTTTCACAAATTAAATACTGGTAGAATGAAAAGTCATTGTTTTTTCTGGAAATAGGTCTTGCATAATGTTGCTAATTGCAATTTGTGCCTCGCCAAATCCTAAAGCAATCATTGGCACTCTTCCAGGATAAGTAATAGCATCGCCAATTGCATATACATGAGGAAGGTTGGTATGCATTTTTTGAGAAACAGCGATTAGATTATGGTCTAATTTGATCCCCCATTTACGTAATTGTCGATTATCGCTCTTGAAGCCATATGCAACTAGGATTTCATCAACATTTTTAGTAACAAAATCTTGACTTGCACCAACTTTATGCAAAACTAATTCCATTCTATTATTGTTTAACTGCAGATCTTTTGGAAGATAAGGAGTTAAAAGTTCAACATTTTTTAAACTTTTAAGCTTATTGACGGAGCTTTCAAGACCGCGAAATTCATTTCTCCGGTGAATTAAGAATACATCTGATGTGTTTGCTAATTCTAGTGCCCAGTCAAGTGCAGAATCTCCACCTCCAAGAATGGCTACTTTTTTGTTAGCAAAGATTTCAGGATGCTGCATTGAGTAATGGATATGTTGGTTTACGTCTAAAGTAGTTGATAAAGGAAGAGTTTTGGGCTTAAACGCGCCAAGTCCCGTAGCAATTAATAAACTTTTTACTTCATATTTTTTGTCAACTAGGATATTTTCATTTTCTAAAAAAGAAATCTCTTTTACTTTATGAGAAAGAATGAATTTAGTATTGATGTTTTGCTCAAGTAGCTGAGAAACTAGCTTTTTACCTTTAATAGAAGGAAAAGCGGGAATATCCTTAATATTTTTTTGTGGATAAAGCATATTAATTTGACCGCCAATTTCGTCTAATGCATCAAAAGAAATTGTCTTTAGTCCATGTAAATTAGCAAAAGAGGCTGCAAAAAGTCCAATAGGACCTGCACCAATAATAGCTAAATCATATTTTTCCATCTTTATAAGAAATCCTCCATAAAAATTAAGCATAGAAGTCATGTCTTTAGCGTTAATTAAAAAGACAGTTATAATTAATATTAGTAAGGGATGAGATAGTATGCAAGTTAAAATTGGCGATATAGTTCATGGAAAAATTAGTGGGATACAACAATATGGGATTTTTGTAAGGCTAGATAGCAAAGTAGAAGGCTTGATCCATATCTCTGAAATACATGGTGGATATGTTAAAGATATCGGAAGAGAGTATCAAGTTGGTGAAACAATAAAGGTACAAGTAATTGATATAGATCCATATTCTAATCAGATTAGTTTATCTAGAAGGGCAGTCCTTCCTGAAGTAAAAGAAGCAAGAAAAAAGCGAGTCCATTTTTGGACTTCAAAACGAGTTAAGAAAGGTTTTACTCCTTTAAAAGAAGTATTGAATACTCAAATTAAAGAAGCAAAAAGTAGATATTCTAAATAAAGAGTAAATAAACGTGTTAAGGAGTAGTGCTTAACACAGTTTTTTTATATCCGAATTTT
+>1_2#NODE_6_length_39999_cov_63.2183_ID_11
+GGAGGTCACTGAGCTGGGGACGTTTTCCGTCAATACCCTCACGACTTTCCACACCACGGTTCAGCTGGCTCAGTGCGATGATGGGGATGTTCAGTTCTTTGGCTAACCCCTTCAGTGAACGTGAAATGGTACTGACCTCTTCCTGACGGCTACCGAATGACATTCCGCTGGCATTCATTAACTGAAGGTAGTCAATGATAATGATTTTTACTCCATGCTCGCGTACAAGCCGTCGTGCTTTGGTGCGTAATTCAAAGACGGACAAGGATGGTGTGTCATCCACATACATCGGAGCATCGTATAATTCTTTTATTTTATAATCCAATTGTCCCCATTCATACGGAGCCAACTGACCACTCTTGATTTTCTCACCCGGAATTTCGCACACGTTGACAATCATACGGTTGACCAACTGTACGTTGGACATTTCAAGAGAGAACAAAGCCACAGGGATTTTCGCATTTACCGCCATGTTCTTTGCCATGGAAAGCACAAAAGCCGTTTTACCCATAGCGGGGCGGGCGGCAATAATCACCAGGTCGGAATTTTGCCAGCCCGAGGTCATTTTGTCCAATGCATGGAAACCGCTTTCCAGACCACTCAGCCCGTCCGTTCGTGCCGCCGCTTTTTGAAGCATCTCATACGCTTCCTGAATGACAGGGTTGATTTGCGTATAATCCTTCTTCATGTTCTGTTGCGAGATTTCGAACAGTTTTCCTTCCGCTTCCTGCATCAGGTCGTCCACGTCTTGGGTTTCGTCGAAAGCCTTTGTCTGGATGTTGCTGGTAAAGGTAATCAGTTCGCGTGCAAGAAACTTCTGCGCGATGATACGTGCGTGATATTCTATGTGTGCGGAAGAGGCTACCTTGCCGCTTAGCTGTGTTATGTAAAAAGGACCGCCTGCATCTTCCAGTTCACCGGTGCTGCGTAATTGTTCGGCCACAGTCAAGATATCGACTGGTTGCTGGCGTAAAGCCAAAGAGGTAATAGCCGAATAAATAAGTTGGTGACGGCGTTCATAAAAAGATTCGGGACGAAGAATCTCACTTACTAATGAGTAAGCATCTTTTTCTATCATTAAGGCTCCCAATACAGCTTCCTCCAGCTCAGGTGCCTGGGGCTGTAAATGTCCGTATTCGTCAACAGGCTTTGCTTTCGAAGTTTTGGGAGTACGTGTCATTTTTCTCGTTTCTGCCATTGTCGTCTGTTTAAAGTAGGGCAAAGATAGAACTTTTTGCTGAGTTGGACACTCGTCCATTCCCAAAAATAATAAAAGAAATATGAACCTGAATCTACGGAGAAATGAACAATCTGGACAGTAAATGGTTTTTTTATATGGTAAAATGAAAAGTTTGTTCTATATTTGGCGCTCTGTCCGGATAAAAGATGGCGTGCATCTTTGTAGAACGGGCAACAATCTAACGAAACACACTAAAAATAACTATTTAAAGAACAGAATATGATTACATTTCCTAATGCAAAGATTAATTTGGGACTTAATATTGTAGAAAAGCGCCCGGATGGATACCACAATCTGGAAACCATATTTTATCCGATAAACCTGCAAGACGCTCTGGAAGTGACGCGGCGGGAAAACAATGACAAAGAATACACTTTACACATAAGCGGATCTCCTTTGGAGGGTGAACCCGAAGATAATCTGGTAGTAAAAGCCTATAAGTTATTAAAAAAAGACTATCCCGGACTGTTGCCGGTAGATATACACATGTACAAGCATATACCGGCGGGTGCCGGACTAGGTGGCGGATCATCAGATGCCGCTTGTATGATAAAGCTTCTGAATGATAAATTTTCATTGGGACTCAGTACGGAACGGATGGAGGAATATGCGGTAAAACTAGGGGCAGACTGTGCTTTTTTCATTCGGAACAAACCTGTTTTCGCTACCGGAATAGGGAATCTGTTCGAGCCTGTGGAATTGTCATTAAAGGGATACCATATAATTTTGATTAAACCTGATATCTTTGTGTCCACCCGGGATGCGTTTGCCGAAATAAAGCCTGTGCGTCCGGCTGTTTCTTTGAAAGAAATTGTAAGGCAACCTATGGAAACATGGAAAAACAGTATGAAGAATGATTTTGAAGATAGTGTCTTCAAAAAGTTCCCTGAGATTGCTGCTATCAAAGATGAATTGTATGATTTGGGGGCAGTGTATGCCGCCATGAGTGGCTCGGGGTCTTCCGTCTATGGTATTTTCAAAGCACCGATAGAGAATGTGGAAGATAAATTCTGTGGATGCTTTTGCAGACAGAGAGCGTTGGAATAGTGTGGCAGATCAGTGGTTAGTGATTAGTGGACTGCGCTGTCATGCCGCAGGTATTAACCACTAACCACTATAGTCTATCTTTTACATAGTGCCTTGAAATCACAATAGGTACATTTTTCTATGATTTCTGTTTGGGTAAATGATTTTTCCGGATTAAATATCTCTTCTAATAATCCTTGAAGTCGTTCACGGTATTCTTTTTCATATTTACTGAAATCTTCCACAGCCTCTTTGGGCTTTCGTGGCTCGCCCATTTGTATAACGGGAGAATAGGTTTCTGTAGCGGCCCGATGAATATAGAGAAGGGCCGGAGCTATCTTCATCGTTGGTTGCTTGCGGCACATGATGGCGGCATACAGGAACGTCTGGAATACATAGTTGGAACGTTTCTTGTCCGGAATAAACAGAGATTCCACATGGGGTGGGGTGTCTGCATCACCGCCTGTCTTGTAGTCCACAATACGGAGTGTGCCATCCTTGCTGTCCATACGGTCAATAATTCCCCCGATACGTGATTTTATGACTCCTTTGGGTGTTTGTATGTCGATGGGTTCATCCACTTCCATTTCCGATGCAATAAAAGTGAAGGGAGCGTAACGTAAATCATTTTGTAAAAGTTGTTTTAAATATCTTGCAATAACGGCAGAGTTGATAAGTTGTATGCCGTTATATTCCGGTTTCTCGTTTTGCGGAACATTAAAGAATAATTTCTTGAATGCTGTATCCACATAATCTTGCAGCTTCACTTCATTGCGTAGCAACGTTTCCAATGCTTCCTTATTAATGACTTTGCCATGAGTGGTCAGGTCTTTATAAATATGTTCGGCTGCATAATGGAAAATACTTCCGAATGTGGCAGAATCTATTTCCGCACTCACTTCATCGGGGGCGGAGAGGCCGGCTACATACCTATAATAAAATTTTAAAGGACAATCCAGGTAATAATTCAAGGCTGATGGAGAAAATTTTGCTTTGGGATTGGCACGGACATCAAACAGGCTTTGCATCCGGCGCATGACATCCGGGGTCTTTTCTACAGTGATAGGCGAGGTGCCTTGGGGGGACTGTCCGGCCTCCAGAAACTGGCGTGTGATGGGGTGAGGCCATTCAATAAGGAATTGCAGCATGAAACGGCTCCATTCGCCGCGGTTCAGTCCGTCCGAACTGGTATTGTACATCAAGGTAATCCTTTCTGCCCGTTGCAGCAGACGATAGAAATAGTATGCATATACGGCAATCTTATGCTCTATAGTAGTCATTCCGAAAGCTTTGCGCAGGTTGTAAGGAATAAAGGAAGAGTCTCCTCCCGATTTGGGAAGCTGCCCTTCGTTGACCGATAGTAATACCAAGTGGCGGAAATCCAGGTTACGTGTTTCCAATACCCCCATGACCTGCATACCAATGGCCGGTTCGCCATGGAATGGAATATTGGTCGCTGACAAGACCTTGACCAGCAATCGCCGGAATGTTTCGCTCTGTACGGTTAATTCATCTTCTTCTATCAGTGTGCGGAACCGGTTGATGGTGGTATAGGCTTTGAAAAGCGACTCCCGGTAAAGTTGGTTGAATGCATCTGTGTCCTCGGTACCGGAAGTGTTTGCCTGGTAAATGCCTGCCACTTGCTGCAAAGTTTCGGACAGGCGTATGCACAGATTCAGGTTTCCGGAAAGCGGAGTGAAAAGCCGGGTAAGGAATTCATCTTTACCCAATTCGCCGGGTAACGGATAGAAACGGTTGTTCCGGGTCAGTTCTTTTTCCAACAATTCGGCTTGACCGGTGAGTTGCCGGGTATAGGGGTGTTTTAACAGTGTAACAACCGATTGAAACGTGTAGCGGCCGCTTTTGAAATTAAATCCGTGGGTATGCAATTCCAGTAAGGCGATGAGGAAACTATATACAGGAGTTTGCGATAACGGAAATCCCATGGTGATATTGACATGTTTTACTTCTGCCGGCAATGAATGGAGGACCGGCTGAAGCAATGCTTCGTTACACAATACGACTGCGGTTTCCTTTTCCGGTGTAGTCAGATTGTTTCGTATCCATTGAGGCAGGTAACGGGCTTGTGCATTTTCAGTAGAAGATGCGATGTAGTGTACCTCTTTAGGTTTCGAGAGATTTTTGAATAACTCACCGGACAAAGGAGAAGGAAAGTCGCGTAAGTTCCGGCGGATAAACTCTCCGGCTTCATGGGTGACGGCTTGTCTGTTTTCCTTCATATAAAATTCGTCGTAATCCCAATAAAAAACAGCTTTCCCGGCATCTTTCAATTGGGTGAACAACGTATGTTCTACTTTGTTCAGTACATTAAATCCTACAAAAACATATTTCTCGTATGGAAGTTTGTCCACATTCAGATGCTCTATGACGTGGCGGTACATCATTCCTTCGTAGGCAATGTTTTGAGAAGCTAAGGATTCACGGAACCCTTTGTAGATGTTTCCCAATACGTCCCATAAAGAGATAAACCGTTCTTTCAGCGCTGTTCTCCGTTCGATGGAGAAGTTCTGGAAGAACTGCCGGATAGCTTCTTCCTGCTCATCGTCAATGAAGGTGTAGTCGTCCATTATGTTGCGCAGATCCTGTAAATTGGAAAACAGTTTGTCGGTATCCACTTTATTTTTGTCGGCATCGTCAAAATCACTGATCAGCATTTCTCCCCAAAAATAGAAATCATCCAGTGTTTCCGTACTTTGAGTTTCCCGTCGGAATATCTTATAAAGTTCGCATACCAGTTTTACCGGATCACCCACTTCCCATGGAGAAAGGCTACGGAACAATTCGCTGATGCTGACGTATGCGGGCGACCAAATAGGTGAATCCGACTCTTGGGCGAGATACTCATTAAAGAAAAGTCCGGCACGTTTGTTAGGAAAAACCACGGCTGTATGTGCCAGGTTTCCTTCCGTATGTTTATATAAATCGGCTGCTACCAGTTTCAAAAAGCTTTCCATTATTCTATTTCCTCCAGTTCGTTGTTAAATACATACCATAAATAGCCACGGATATGCTCATATCCCATATCCGATAATAAATCCATATATTCTTTCACCTGCTTGTTGTAAGCTTTCCGCTTTTTACCGAATTTAAAGTCCACCACAATCACCTCTCCGTCTTTCATCATCACGCGGTCCGGACGGCGGGTTTGCAGCACTCCTTTTTCCCGATAAATAATGGCACACTCATTGTATAGTTCCCAGCGGCCCGAATACCATTCTTTGACCAGCGGATGCTTCAAAGCCCATTCGGTGAGTTTTCGTATTTGTTCTTCCTGTTGTGCCGACTCTATGATTCCTTCGAAACGCAGGCGTTCTATGGCGGGAGGCACATCGTCCGTGGTACGGATTACGGAGAACAGATTATGCAACAACTGTCCTTGCCGGATGTATTTGTCTTCCGCTTCCTCTTCTCCCCGGATAAATTCGGCAGAACGGTTGGACTGCTTGAATTCGATGTTGGTTTCCAGCGTTTCCAGATGGATAGGCAAACGTCGGGCTACAGTCAGCAGCTTGTTGCCGGATACTTGTTTTTCCTCTTCGTGAGATGAGAGATAGAGCGTTCCCAGTTCGTATATTTCTTCTCCGGTGGCATAGCTCTTTCCGGTCATGTCGGATAAGGCACTTTCCAACAATTCGGATACCGTTCCTTTCTGTTCCGCCTTTCCATATATAATCAAGTTCTTTTTGGCACGGGTAAATGCCACATAAAGCAGGTTCAGATTATCCACCCATAATTGCAAGCGTTCATTCAGGAACTCTTCCCGATAAATGGATTGTTGCATGGCTGTGGAATAGTTGATGGGAACAATGTCAAGATCGCTAAACGGAGCTTGCCGGGGAGCACACCATACCAGATGATTGTAAGTCTCATTCTCCATTTTCCAGTCGCAGAAAGGTAGCAGTACGGTATGGTATTCCAATCCTTTGGACTTGTGGATGGAGAGAATGCGAATTCCTTCCACCTCGCCGGAAGGGATGGTCTTGCTGCCTAGTTTTTCTTCCCAGTAGGTGATAAAAGCGGATAATTCGGAAGAATTGCTTTGCAGATATTCCGTCACGGCATCAAAGAAGGCGCACAGATAGGCATCCTGTTGTTCGATGCAGGACATCTGGAACAGATTGAAAAGTTTTTCCATCAGCTCATACAGTGGCATGAGGCGAAGTTGCTCCGCTTCTTTTATGAAATCGAATGGCAGATAATCATCTATCTCGTTCAGCAATAGAGTGTTGAGGTCTATTCCTTTATGTAATACTTCATTCTGATAGGCAGTAGCCAGTTGTGCCTTGGCAATCCGGTTTTCGGGTTGTGACAAGTAGCGCAGGCCATCCATTATCATACATACCGCCAGTGAGGCATCCAGTCGGAATGCCTCATCGGATACGATTTTGTAAGAGGTGTTCTTGTCGAAGTAATCGGCTATTAAAGGAATGCTTCTGTTCTTGCGCACCAGGATGGCAATATCTTTCAGTTGCACGCCCTGCGCCACAAGCAGCTCCACTTCTTCTCCTAGGTGGTGCAGGGTGTTTTCCATATAGGTCATGTCTTCCGTATCCGATAGAAATTCCACTTTGACATACCCTTTTCCGGGATCTTTGTATGTTTCCTGACACACGTCGTTGTAGGCTTCCTTCAGTTCCTTGCATTCCTTTTTTTGTTCTTCCTTGTAAATGTTGTTCAACACCTCGCAGGCGGCTGTAAACACTTCGTTGTTGAAGTGAATGATGTTTGCGGCGCTCCGGCGGTTGGTGGTCAGTGTCTTTACTTTGACGGGAAAGGCTTCGATGTTTGTTTTCAATCCGTTCAGTATGCCCCAGTCACCGTTTCTCCAGCGGTAGATGGATTGTTTCACGTCTCCTACAATCAAGCTGTCTGCTCCCTGAGACAAACCTTCGAGCAGCAACAGACGGAAATTGTCCCATTGCATACGCGAAGTGTCCTGAAATTCATCGATCATTACGTTGCGTATGGTTGTTCCTATCTTTTCGAATACAAACGAGGAATCTCCTTCTTTTACCAGGTTATGAAGCAACGCGTTGGTATCCGACAGCAGGAAGCGGTTGTTTTCATGGTTCAATTCGCGTACCTCTTCGTCTATATTGGCCAGCAGACGGATATTGTTTACGTGGCGCAGGGAGAGTTGGCAGGAATTGGCCAGCATATTGTTCCGGCTTCTGTATTTTTCCGATTCATTCAGCAGAGGAATCAGTTCTTTTTCTGCCAGACCTTGGATAGCGTTGCGTATGGGGGAGGTTTTTTTCACCCATTCGTCGGGGCAGTCCAGACATTTTTCCACTGTTACATTGCGGACACTGTCATCCAGTTTACCCGATTGTAATTTATTAAAATAGCTGGCTATACCTCGGGAGCCGTTTTTCAAATCTTCTACTTTCACCCCGTTTGTATCCAATATTCCGAAGAATTGGTCGGCAAATCCTTTCATTTGTTCCTGCACCTCTTCCAAAATGGCTTGCAGCGTTTCGCGGTAATTCTTGATACAGTCTTTGTCCCGTAATTTTTCCCGTAGTCCGTTTCCTTTTTCTATATATCCTTCATCGAAGATATTTCGTCCGAAATTCTTTATCTCACCGGAAACATTCCACCTCTTGTCATCGGCTATTCTTTCTTCTATGTATTCCAACAGCCAATAGAGTACGGGAGATTGTCGGTCCAGCTTTTCTATCATGGAGTCCACGGCATCACTCAGTACCTCCATATTGTTCAGTTCGATATTCAGATTGGCACCCAATTCCAGCTCCCGTGCCAAATTGCGCATCACCGACTGGAAGAATGAGTCAATGGTTTCCACCCGGAAGCGGCTGTAATCGTGTATCATGTAGTGCAGTGCCGTACCGGCGGCTGTCCTTATGTCTTCTTGGGGCCTTTCCAGTTCTTCTGTGATTTTCTGTAAATAGGGATCAGAATCCTTATCCTTTATCCATATTCCGTATAGCTGGCTCAGAATCCGCTCTTTCATTTCGGTAGTGGCCTTGTTGGTAAAAGTCACAGCCAGTATATTACGGTATGCCCGTGGGTTCTGTATCAGCAGTTTTATATATTCCACGGCCAGTGTGAATGTTTTTCCCGAACCGGCAGAGGCTTTATAAACTAATAATTCAGGAGAATGTTTCATTTTAAATAATTTGCTAATTTGCTAATGGCTGCGCTGTGTACCGGATGGTAATTGGCTGACACATTAGTACATTTTTATTTTTAATTAAAAACCAGCACAAAAACAGTGGCCTGTCCCTTTTCCTTGTAAGGCAGCAGGGTCAGTGTGCCACCGCTCAGTCTCATGATTTGTTTGCTCAGGCTCAGTCCGATGCCGCTTCCTTCCTCTTTGGTCGTGAAGAAAGGTACAAAAATTTGTCCGGCTGCATCGGGAGGAATGGCGGGACCGTTGTTGGCTATCTCTATACGGATACTTTCTTGCGGATCACAATAAGCTTTCAAGGTGATCTTTCCGTCGGGAGCATTACCTATGGCTTGAATCGCATTTTTCAGCAGATTCGTAACCACTTGGGCTATCAGGTTCTCGTCGGCAAAGACTATCAGGTCTTCCCGGGCTTCGAGGATGGAAAGGGTGATGTTGGGGCATGGATGCTGGTGCTGTGCCAGTCGGATCATCCGTTCCAGGAAAGGACGGACATAGAACAGCGATGGCTCAGGTGATGGCAGTCGTGTCAGTTTGCGATAAGACATGACAAAATTTATCAATCCTTTACCTGTAGAGTGAATCGTTTCCAGCCCTTGTTTCATTTCTTCATTTTCTGCTCCGGGAAGAGCCAGCAGTGTTTCGCTGAGGGAAGTCACCGGGGTCAGGGAGTTCATAATTTCGTGTGTCAGCACGCGGGTAAGGCGTATCCATGAATCTATTTCCCGTTCATCCAATTCCCGATTGATATCACTCAAGGCAATAATGCGGAGTTCCTCGTCTTTGATACGGATGCCGGACACCCGTAAGGCAAGATGCACCGTTCCCCGTTCCGTATTGAACTGAATTTGCAGCTTGTCACCCGGAACTGCTTTTTCCAAAGCAGTCATCAGTTCATCCGAGATGCGGGAGAGTTGTTTGACATGAGTCAGAACATCCAGCCCCAACAGATTCATGGCCTCTTTGTTCTTTTGATAAACGGAGCCTTTGCTGTTCAGTACCACTATGCCGGTTTCTACAAAGTCCATGATGAGCTCATAATACTTCTCGCGTTGTGCCGTTTCCTGTTTTACATTGTACAAAATACGTGCGATACGGTTCAGCATGACATTGACCATGGAAGAATCGCCAGGGGAGGCATGTTCGTAAAAACGAACAGCGGGGTCGTCGTTTTCGATGGCGTCGAGCAGAAAGGCTATCTTCCGGGTATTAAAAGTGTACAGGCGGTAAAACCAGCCTATGGAAACGAGGAATGAAGGTACGATTACGCATAGCCACAACCAGTTGCGCTGCTGGATTAGTAAGGTGCAGGCAATGGCTAGAATCAGTACGGTAAATAGGCGGAAGAAGAATTGTTTCACAGCTTAATTATTTATTATTTCGTTTGAATGTTCCTTTAGTTCCTGTTTAAAAATAGATTATTGTTATTTGTTTTGTCATCCTGAACCATCGTGAAGAATGAGATGAGATAATAGGTCATAATCCGAATTTTTTCATCTTATTATAAAGCGTCTGCCGGGTAATTCCCAACTGTGCCGCTACAGCCGAGAGGTTTCCGTTGCATTTCTCTATCGCTTTCTGAATCATTTGCAATTCCATCTCCTCCAGAGTTGAGACACTTGTTTCTGTCGCAGGAGCCGCTATTTTTCGGGGAAAATGAAAATGTTCCTCACTCAATATACCATCTTCATTGATAATGACCGCTTTCTCTACGGCATGTTCCAGTTCGCGTATGTTTCCATACCACGGATATGTCCGTAACTTTTCTTGCGCACCGGTAGAAAGAAGGATATTTCCTTTGTCATATTGTTTGCAGAACCGGTCTATAAAGCGTTCGGCCAAAGGGATAATATCTTCTTTGCGTTCCCGCAGAGGGGGAATCTCGATGTGGATGGTATTGATGCGGTAAAGCAAATCTTCGCGGAATTTGCCTTTGGCCACCATCTCTTCCAAATTACAATTGGTGGCGCAAATCAAACGTATGTTGACAGGTATCGGTTCGTTGCTTCCTACTCGCACCACGCTCCGGCTCTGAATGGCGGTGAGTAGTTTGGATTGCAGGTGATAGGGCAGGTTGCCTATTTCGTCCAGAAACAAAGTCCCTTCATGGGCGGCTTCAAATTTACCTGCACGGTCGGTATGGGCATCGGTAAACGAGCCTTTTTTATGACCGAACAGTTCGCTTTCGAACAGGGATTCGGTGATGGCACCCATGTCCACTGTTATCATATCCCGCCGGTATCGGTTGGACAAGGCGTGTATTTCCCGCGCCAGCATTTCTTTTCCTGTGCCGTTCTCTCCTGTAATCAGAATATTGGCATCCGTTTGCGCCACTTTCTCTATCAGCGTCCGCAGTTGCTTCATGGCATTGCTTTCTCCCCAATACATAGAAGATACGGTTTTAGGGACTTCTGCCCTCTTCTTGTTCTTTGAGGAATTGCGGCAGGCAGACAGCAAGGTTTCTATCAACCGGGTATTGTCCCAGGGTTTGACGATGAAGTCTGTCGCCCCTTCCTTGATGCCGCGCACTGCCAAGTCTATGTCAGCGTATGCTGTGAAAAGTACTACGGGCAGGGAGGGGTGTATTTTCTTTATCTCGTGTAACCAGTACAGACCTTCATTCCCGGTATTCAGTCCGCTGCTGAAATTCATATCCAGCAGCACCACTTGCGCATTTTCTTCACGTAACGCAGCGGGCAGTGTGATGGGTGAGGGCAGTGTGACGATATGTTCGAAATGATTTTTCAGCAATAGCTTTACTGCCGACAGCACTCCTTTGTTATCATCTACCACAATGATGGTTCCTTGTTTGCTCATAAGTCGTTGTAGCTTCTTTTTTCTTTAAAGATATCTTTAGTTGTACGTTTCATGCAAAGGTACTATCTCTTCACACACTCTCATTTCCATTCCTTTATAGACCACTACTATTTTGTGTAGCTGTGTGGTGCCCACAGCATTCTTCACCCGGTCGGAATCAGCATAACGATTTGCCTGAGCGATCCCTTCCAGCCTCAGTTCTTCCACACGACTTTCAGAATCTTTGTATTTGGCATATTTCAACTCTATGATATAACTGTGCTTCATGTCCGGATAGATTTCCAGCAAAGGACACAGGAAAAGATCAGCGTATCCTTCTTGTGTATCCGCTTCAGAAATAGGGCGGTAGAAGCGGTTTTGCGCTGTCATGGCCAGTGTGAATCCATGTACGAAAAACTCTCCTTTCTGTTTGTCACGTTGTGAAGCGTAACGTTTCAGACAGTCGGCTATGTAACCGAAGTAGGCCTGCCAGTTACCATCGTATGCCAAAGCCGAGGCCAGTTCGTCTTTCTCATGACTGCTGAAACTAAGGTCGGCCTCATTGTATGTATTCAGCAAATAGGTGTATAGTTGCTCTTCCACTACCTGATTGGGAATGGTGAGTTTGTTTTTTCCTTTATGCATTCCGCTGATGGTAAGCATACCGAAATAATAGAGCAGACTTATGAAATTGTCCGGATCGACAATATTCGCAGCCGGAAAGCTATCCTTCAGTTCTCCGGTGATATATCCTTGACTTACCAGGGTTTGTATGATGGATGCATCATGAGCAAACTCCTTGTCCTTGCGAATCAGCATCCGGAGTTTTTCGTAGTCTATGCGTATGTTGCTTTCTATCATTTTCTGTGGCGCTTTGCCGCGCAGAATATAGTTTTTGACAAAATAGAGAACCATGTTGGAATTGTACAGGGTAGTTTCTCCGTAGCATTCCGGTGCGAAGCAGTAGTTGTCATACCACGGCTTCATGATATCTATCAGTTGGCCGACGGTATGGTTGAAAGGACTGTTTGTGGAATAATACGTCAGCATCTCACGCACTTCCTTTTCTGTGAATCCTGTCATTTCGTTGAACTCTGGTGAGAGGGAGTAATTGGTACCTATATTGAATCCGCTGGTGAGATCATCCATGGTTACGGGGCTTACTCCGGTGATGAAGCAACGCTTGATGCAGGAATCTGTTCCGGCTTTCACTTTGTTGAAGAATGCGCGCAGGTAACCCTCTTTGTGTGTCTCTTCAGTGTATCGGTGCAGACTTTCGGCATCGGAGAGAATGGCATTGGTAAAGTGGTCATACTCATCGATAAAAAGATAAATTTTCTGCTCAGTCTTGTTGCACTCCGTAAACAGATATTCCAATTGTTCTACCGCTCCTGATTTTTCATCCAGCTTCTCTTTGATACCTTGTGGGAGATAGTCGGCATAGATATCGCAGAAATAGTCGAACATGGTCTGGCAGTGTGCGTCCAGTCCTTGACGGTAGTTGTGCAATTCCCCGCTGATACCGGAAAAATTGAGTTTCAGCACTAGATAGCTGTTGCGGTCCGGCGTGGGGTGCTTTCCTATGTAGAGGTCTCCGAACAGGGCGTCAAACTTATCGCGGGTGCGTACATCATAATAATGTTGCAGCATGCTCAAGGTCAGACTTTTGCCAAATCGCCGGGGACGGATGAAGAAGAAAAACCGGTCCGACTGTTCTATCAGTGGGATGAAGGCGGTTTTGTCCACATAATAATAATTGTCGAAACGGATGTCTGCAAAGTTCATCATACCGTATGGCAATCGTTTCCTGTTTGAAGGTGCATATTCCATTAGTTATATTATTTTTTTTATGAATAAACTCTGGTAAAAGAGATATGTATGGCATACAAAGATACTTTCTTTTCCCTGCTTCTCCAAAAAACAAAGGTTCTTTCTTTTTGGTAACATGGAGGAAGCTGTCCGATAGGTATCCGCCAATCTTTTCTTTCAGAGAAAACTTTTCAATTTCATGAATTGTTCTATTATAAAATAGCATTTCAAATGAAAACATTTATATTAAGCATAATTGTAACCATGATTACATCGGTAGCTGGTGCACAGCAAAAAAGTTTTTATGACTTTACGGTCAAGACTATTGACGGGAAGGACTTGCCACTTTCCACATTCAAGGGTAAGAAAGTATTGGTAGTCAATGTGGCATCTAAATGCGGTTTCACTCCCCAGTACGCCAAGTTGGAGGAGTTGTATGAGAAATATGGAAAAGATGATTTTGTCGTTATCGGATTTCCTGCCAATAATTTCCTGCATCAGGAACCCGGAACGAATGAAGAAATCAAGGAGTTTTGTACGTTGAATTATGGAGTGACTTTTCCTATGATGGCTAAAATATCTGTAAAGGGAAAAGATATAGCTCCCCTCTATCAATGGCTTACGCATAAAAGTGAAAACGGGGTTTCGGATGCTAAGATAGGGTGGAACTTTCATAAGTTTCTGATTGATGAAAATGGTAGATGGGTTGCCTCAATCGGCTCTACTACCAGTCCGCTTTCACAGGAAATTGTAGGATGGATTGAAGAATAAAATGACCAGAAGATAAATAATGCCCTATTGTTATTGCACCAGCTTTCCGTTTTTCAGTTCCGACATCAGCAGGTCATAGATGTATGCCGGGCTTTCGATATACAGGCCGGTGGAGAAGTCTTCCAGTTTGACGAATGTCTCCGAATTGTGGAATGTGGAGATGGCTTCCTGCAAATCCATATCATTACGTTCCACCAAGTAACGGACTACATCGGCGGATATTCCTTCAAAGAGGAATTTTGCGGTATTCGTGTTCATAGTCGTTTCAGCATTTTAATCGCTGCCTCTGAGTGAAAGAAATATTGTGAAGTCACTTTCGAAAATGTCAGTTCGTGCAATAGTTGTTCTTCGTTAATAAAATTCTCGGTGTATAAACGTAGCAAGCGCGCAATGGTATCATCGGCAACAGGGCCAATTACGATATCGTAATCGTGGCAAGGCTGAGTAGTGTTTATATCGCGGTTCGACATGACAAAACGTGCCCATTCCCAGTCTGGCTCCTTGAAAACCTTGACTTTCAATTCGCTCGACTGCGCTTCTTCGAGGTCAAACTCAAACATAGTCAGAGTGGGGTTTCCGCTGAACATCCGCGCTGTTCTTGCGGCCATCCTTTGGGCCTGTTCCCTAATGTCGGTCAGGTAAAATCCTCTGCCGAAATCCTTATAGGGGCGGCATCTGTTGAGGTCGATGCCGTCGATTGCCGTATTTGAACCGTGGTAAAGTATCATCGCAATGTTCCTCCATTGTTTTGGCAGACGATGGTCAGGTCATCCACACAGTCGTTAAAAGAAAGCGTGTGTTCCACATCGTAAAATTCGGTGAGAAAATCAATGCCTTTGAAACGTCTGATATAATTGCTTGCCTCCCGGATTGTCAAATCGTGACGGCGCGCAAATTCGACAATGACCGTCATCACATAATCGATTAGGTTCTTGTCCGCTTTCTTTTTGGACTTGAGCGCCACTATCGGTTCGACACCCAACGCCTCCGCTATGCGGTTGACAGTGCCAAAATTAACACACAGACCGTTTTCCACTTTGGAAACCATTGCTTTTTGGACGCCAATCATCACCCCGACTTCTTCTTGTGTCAATCCTTTGTTTTTTCGGCATTGGGCCAAAAGTTCTCCTATTTTTTGCAAATTCGTATTCATACCACAAAAATAGATAAAGTTTCTTGTGTAGGAAACTTTTTAACTACAAATATATTCTTTAGATAATTATTATCTTTCCAATTAAATGGCAGCTCTGCTCTGACACGCAAGAACCCGTGTGCCGGATGATGATTGTTAGGAAAACAGGAGGGAAATCAGTTCCTTTGTACATCATAGGTTATGGAACGGTGGTTCGAAAAGAGTTGTCGCTATTTTTTTGCTTATTTATTTGTGGGGATAAATATTTATCCCTATATTGTATTAGTAAAATTAAAAATATCATGGAGAATGATTATTAAAACTGAAAGTTATGGATACAATAAAAGACATTTGGTTTGATGCTAACCGCATTTATATGAAAACGGATGGTGGAGAAACTTTCAGCCGTCCCTTAGAGGCATTCCCTTTGCTGAAGGATGCAAGTGATAGAGAGCGCCTTGATTTCAAGATAGGAAAGTTTGGTGACGATGTTCGTTGGGAATCATTGGATGAGGATATTCATATATCCAGTTTTTTCGATACAGCGGAGCCGGATTATGAAAATGAGATAGCAATGATATTTAAACGTTTCCCTCAACTAAATGTGTCAGAGGTTGCACGTAGTATGGGAATAAACAAGAGTCTTCTTTCCAAGTATATCTATGGTATTAAAAAGCCGAGTGATATAAGGAAGACGCAGATTAAAGAGGCTCTCCATCTTTGGGGAAAAGAATTACTTGCCGTTTGATTAATCTCTTAATAATAGTTTAGGTGTGATTCCATTTGGTTTCACGCCTTTTTTATGTTAATTTTTCCACAATCATAGTTTCAATAGAAAGATAATTAAATATAAGGAAGATATGGCTAGAATAAACAAATACGGCTATGTTGCTGCGTGACGTTTTTGCATCCGTCAGGGAGATGCGGTGAACAAGCCAAGCTCATACCAAGAACCGGGCAAGCATGTGATGCAGGCAGGGTAGGCGTGTACCGAGTACCAGGTAGCCTTGTTTGCTGTATCTTATATCTTACCATCTGGGCGATGATGCGCCCGGAAGAATTTGCATCAAGGTAAGTATACCGATAATCTGTTTCTTGTTTGTTTTTTGAGTAATCAAGAAACATCACTAAAAATAGCGGAATATATTTTCGTCCTATTTATTAAATTGCTATCTTTGCCACGTTTTCCACGCCGGTACTTCCGCAAGGAAGTTAGGGAGGTGGGAAATATACATATATAGAAAAGACGTTTACTTGACGTTTTGTTCTTGGCTCTACAGAACTTCGCAAATTCTAAAATCCAGCCAAAACAAAGCAACAGTAGGTGTCTGCGGGGTATGTTTATATCCTTGGTGCGCCTTTGCCGGTCAAAGGTGCATTCAAGTGTCATTATACATATCGGCGTGGGCTTCTGCGTTGCTCGTTCAGACTGGATTGGGCAATGCGAAGGCCTTGTAGGGCGGGACGAGTAACAGGTACAGATTCCCGCGCTTTTTTTATATATAGGTATTATAAATTCTGATTTAACACATAAGAACCGTCCGGTTCGGGAATCTGCGGAAGGTCATCGGTTGACCCGACAGGCTGCATCTACATCGTGCGGATTCCCATCCTCCATTTGTTGAAATAGCTTTTCTTTGGTCAGCTTAATCACAAGAGGCCGATTCCTCTTGTATTTTACGAAACTTCTCGTAATTGATTGAATTGCAGATGTATATCTGTACTTCAAAGCTCCATAACTATGCTTTCAAGTGAAAAAATGCAATGGTTTGCCATGCGTGCCACTTATCGCCGGGGGATGCAGATCAAGGCTTTGTTGGATAAAGAAGGAATCAACAATTTCATTCCCATGCGTTACGAAGTTCGTATAAGGAACGGGTGCAAGAGGCGTGAGCTGGTTCCCGTTATCAGTGATCTGATATTTGTTCATTCCGTCCAGTCCGAACTTCAGAAGGTGAAGTTCAAACTTCCGTATTTTCAATATATGATTGATATCCGCAACGGGCAGAAAATCATTGTGCCCGATGATCAGATGAGGCAGTTTATCGCTGTGGCTGGAACGTATGACGAGCATCTTATCTTCTTCAGTCCCGATGAGGTGAACCTGCGTAAAGGTACGAAAGTCCGTATTACGGGTGGTGACTTCGAGGGCTACGAGGGGGTGTTTGTAAAGGTGAAAGGTGCGAGAGACCGTCGTGTGGTTATCAGTCTGCAAGGGGTGATAGCCATGGCCATGGCGACGCTTTCGCCGGACTTGATAGAAGTGATAGAAGAGCCGAAGAAGAAATAACTTCATTTGCTACGTTAAACATTCTTATTCCTTGATTAATGGGGAAGTAAACGATCTGATAATATAAATCTTATGTATAATAATGTATAGAACCACATTCATGCCGTCAGGCATCCGGCTCCAGCATCTGATTCAGAATCAGTATAAGGAAATTTTAGCCAGGGAAAAGAATAATGATAAATTCATTCATCTGTATGACATTGGTGCGTATTGGGTGGCTTTCGAGTGTTCCGCCTGTAGGTTGAGCGGTTTGTTTTCTAAAAGTGAGCTGACTTTGTTTCGTGTCCCGGATTGTGTGGAATATGTGGTGATGGTTTCTGTTCCTGCCGATGAGGCGGAGGGCTGTTTGGGTGAGTACATTATTTTGCACGATGGAATTTACCGGAAAGTGTGGTCGGAGCATGTTTTGCCGATGGGGGATTATCGTCATTGGCATGAGATGGCTGTGAGGTCTGTTTTGTTGTAAAGAAAAGTATGCGGACTTCGTGGACCAAGTAAGTGGTGTTACTTTGCTTGGGAACATATCTTACTTTGCTTACGAAGATATCTTACTTTTTTCAATGGAATATGGTCATTCGTCATGCTCTATAGGGAATACCCTGAAAAATCCTTCAAAAACTTCAGCCTGCTCGCAAACGCCCTACCCGTGGGCATTCCGGCTGAAGGATTGGGCTCAGGAATCCTTCAGCTGGGGGTTGGAATGTTTCAGCCGAACTGATCTTCCTCCGATTCTTAGGGAATCGTTTTTCCTGAAGGATATTTTCCGGCTGAAACATTTCACAATGCATATCCTTCAGCCGGAATGCCGACAGGCAGGGTGTTTGCGGAGTGGCTGAAAGATCTGAAGGAAAAAAAGGCGTTTCGGCATGTAGATACCGTTATGGAAAAAACAACAGGTCAAATTTTAAAAAGCTCTTGTTCTTTCAATGAAAACGTCCTGTTCTTTTTTTTAAAGACCTTGTTCTTTTCGGAAAAGAACAGGATCTTTTAAGGGTTAGTAACGTGTATGCCGGAAGGTTGGTAACGTGCCACCCCACACGTTACTAATGTGTGGGGTGTAAGATTAGTAATGTTGCAGGTGGAAGATTGCATATCTTGCTAGTGATACAATCATAAACGTATGAAGTTCCAGTATATAAAAGATAAAGTTAGTGCTTATTTCACTAAGGGGAATGAGCGTAGTGTTGCGGTGAAGAAAAATATCGCCGTTTCATTAGTGTTGAAATGTATAAGTATTTTAGTTTCCTTGCAGGTCGTTCCATTGACCATCGGTTATGTTAATCCTACGAAGTATGGCATTTGGCTGACGTTGAGTTCCATTATTGCCTGGCTGTCTTATTTTGATTTGGGGTTTGCCCACGGATTTCGTAATCGTTTTGCTGAGGCAAAAGCAAAAGGGGATATGAAGTTGGCAAAAGAATATGTCAGTACTACATATGCAGTGCTCTTCTTGCTCTTTTCCGTAATTTTATTGATAACCTTGGTGGTGAATAATTATTTGGATTGGAGTCGTATTTTAAATATTGATCCTGTTTATAAGGATGAGCTGAGTCTGGTTTTCGGTTTGTTGGCATGCTTCTTTTGCCTGAACATTGTGGCAAGTGTCTTTACTACCATGCTGACGGCAGATCAAAAGCCTGCTTTAGCTTCGTTGATTCAAACGGGTGGACAGGTATTGGCATTTGTCTGTATTTATATATTGACAAAGACGACTTCAGGAAGTTTGAGCGCGTTGGCTTTTGTCTTTTCGGGGGTACCTTGTATACTGGTAATCACTATTTCTGTTATTATGTTTCATGATAAAAGATACAGTTTAGTAGCTCCTTCATTACTAAGTGTCCGTTTAGTGTTGACACGGAATATTTTGGGACTGGGTGGACAATTTTTTGTCATTATGGTTTCTACATTGTTCATTTTTCAATTCGTCAATATCATTTTATCTAGAACACAAGGACCGGAGGTCGTAACCCAATACAATATTGCCTATAGGTATTTTAATGTGGTAAATATGATATTTATCATTATCCTTAATATTTTTTGGTCTGCATTTACAGATGCATATATTAAAAAAGATAGTGGATGGATGAAGAGAATCATTAAAAAATTGGATACATTATGGCTTTTATGTATTCCTGTACTAATTTTAATGATATTGTGTTCTGAAATTATTTTTCAATGGTGGATTGGTAATTCTGTATCTGTTCCTTTTTCATTATCTGTTTGCATAGCTGTATATGTTTTTCTTCAAACAGGAGGTAATATTTATATGTACCTTATTAATGGAACAAGTAAAGTGCGTATACAATTGATTGTCTATTTATTATTTGCTTTAACAGCTATACCGTTGATGACTTTTTTTGCGAAACGTTTTGGAGTGGAAGGTGTTTTGATAGTTCCTGCTGTAGTTTTTGGCTTACAAGCTTGTATTGGAAGAATACAGATCTTGAAGATTGTAAATGGTACAGCTAAAGGTATTTGGCTGAAGTGATGAGAATAATAATGTTTAAAATAAGATTTTCAATGAGACATTGTTTGATTATGACAGCTTATAAGGATGCAGAGATGATAAATTCAATTATAGATGAAACACCTGTAAGTTGGGGAGTCTATATACATATTGATGCAAAATCATCACTTTTATCTTCCATGATAAACAATAGAGCAATTGTTATAAAAAAATATCGTATATATTGGGGTGGAATAGAACATTTATATGCATTTATAGAGCTCATGAGTATGGCGTTAAATAGTGGGGAAAATTATGATTATTATCATTTAATAACAGGTCAGGATTATTATGCTATACCTCCGCTGCAATTTGATACTATATTAGGTGGTGATGGGATGAATTATCTTGACATATTTCCACTGCCAAGACAAGGGTGGTGGGGAGATGGCTTGGATATTTTAAGGTATAGAACATTTTCCTCAAGAACAGATATTCGTAAAGGTATATATCGAAAATTGGATTCATTATGGCGTATAACTCAGAAGATGTTAGGTTTGCAGCGATCACTTCCTTCATATTCTATATATGGGGGTAGTGTGTATTGTTCGTTGACAAAAAACGCTGTAAACGAGGTCGTTAATGGAGAGACTTCAGAAGACTTATTGCAAAGGCTTAAAAATACGACTTGTGGGGAGGAAGTGTATTTCCAAACGATTTTAATGAATTCAAACTTGAGAGATACGATTTTTAATAATCAGTTACGCTATATAGATTGGAATGTGAAAAATGCACCAGGAGTATTGATTGACGAGGATTTTGATAAAATTGTTAAGGGAAAAGCTCTCTTTTGTCGGAAACTCGATTCAACAGTATCCAAATCACTATTAATTAAACTGAAAAAATATATGAGTGATTTTTCCGTTAGATAAAACGATAGGAAACTTAATAGGTATAAGCTATTTTCAAGAAAGGTGTTGGTACAATTAGTAATCATTCTTATCTGTATTGGATGCAGTATACAGATATTGAGAAATAATGGAGATAAACGGTTGGTTTATTTTTTATGGGGAATAATGTTTTGTAATTATGGCGTAGAAGTAATTCCTCATTTAAGTGTGTTGCGTGTTCTGACCATTGCTTTTTATATATCAGTGTTTATGAGAAAGAGTAACAGGCTTATTTTATTGAATATTCCATTAAAAAGACAATTCATTCTACTTTTTATTGCATATTTATGTACTGGGCTATTTGATGATAGAGGGTGTAGTGTAGGATTGTATAAAGCCATTTTGGAGTATATGGAAACTTTTGGATTTATATTGTTAGGATATATAAGTTTTTATCATACAAACGATTTACATAAATTGCTGCATGCAATATTACAGATAGCTTTATGTGTATCTATTTATTCGATAATTACATATTTGATAGGAGCGGATATTGTAAATTCACAAATACCAGGAACAGATTTTAGTATGAATAGTGGAGCGAGAGTCAGAATACCCTCTTTTTATTACAGTTCTCACATAGCAGGAGCTGCTATATCATCAATGTTGATTATAATTATTTCTCCTGAAAATAACAAAAATATAAAACATAGATTATTACTTGCATTTTTGTTATTTATAGCATTGTTATTTACGGGTTCCAGATCTTCCATTTTAGCTTTATTTGTAGGTTTGATATTTGTATATTATTATTTTTATTCTTCAAAAGTGCAATCACACAAAGTATTATTACTTGTTCTAGGATTGGGTGTTGTTGGGGTGGTGGCATCTTTTATAAGCAGGATTCCTTTTCTTTCTGATATGTTTGAGGAGGGAGGGGGAGATACTGGCGGAAGTAATATTTTTATGAGATTGCAACAATTAGTATATAGCTATGAACTTTTCTTACAATCTCCATATTTTGGAAATGGCTTTAAATATTTTTGGGAAGTTGTAAAAGTTGATGATAGCTTTTTAAGTAGTATGCTTTTGGGAGCGGAAAGTTATGTATTTGTTTTATTGATAGAGAGAGGACTAATACAAATTGTTACTATCGTTTATTTCTTCTTCTCATTAATAAAAATTTTCATGCAATATAAAGACAAAATCTTTATCATAACGTGCATGGGTTTAACATGGGCTTTCCTTTTTAATTCAATAGTTACCGGAAATGGAGATAAATGGTCGTATATGATGATATATATAGGCTGTGGCTTATCGGTAATTAGAAATTGCAGAAAGAATATATCATGTACTAAAAAACAATTATAAGATAATGTTTTCTATTATTATTCCTCTATATAACAAGGCTGATTATATTGCAGAAACACTGAAGTCAGTTCTGAATCAAACATATTGTGATTATGAAGTAATCGTGGTGAATGATTCATCGACAGATAATAGTTTGGAAGTGGCTTCTAGTTTTCAGGATGAACGAATTCATATTTATACAAAAGAAAATGAAGGTGTATCAGCAGCACGTAACTATGGTATTATGCGTGCTAAATATGATTACATTGCTTTTCTGGATGCAGATGATATTTGGGAATCCGATTATTTGGAATGCCAAAAGAAGTTGATAGAAATCTATCCTAATGCTGGGATTTATTCTACTGCTTTCTACTCTTTGGAAAAGGGAAAACGGAAACTTCGTAATGTCTTGATTAATGAACACACACACTTCCTTGTTCATGACTATTTTAAAGAATCCGTAATGAATGGATTATCCATTTGCTGGACTAGTTCCTTGTGTTTAAAGAAAGAAATTATAGAGCGGATACCAATGTTTCGAGTAGGTATTAAGCGTGGTGAGGATTTGGACCTTTGGCTTAGAATAGCGTTGAATTATGATGTAGCCTATTTGAACCTTCCGAAAGTCTTTTATAAAACAGGGTTATCTGATAGTCTTACATCAGATTATTCTAAAAATGGAGAATTTCCTTATTATGAGTGGCTTAACTTTACATCGGAAAGTTCTTATTATAGAAAGTATGTGATTTTAGCTATGTATATACATGCAAAAAATGCATTTATACATCATGATTACGATACATGTTTGGCCGAGTTGTGGAGTGTTAAAACTATTGCTTGGAGATTCAAATGGGCAAAGCGATTATTATTACTAGTAATTTCATGGATAAAAAGTAAATAATGAATATCATTTATTTTGTTCCCAATATTACCATTGCAGGAGGTATATTCCGTATAGTGTCAGATAAGATGAATTATTTGGCGGAAAATATGGAAGGACGGCTTTTTTTGGCATATTATGGTAATGGACAGGAAAAACCTATATATCCTTTGCACCCGAACATTCAACTGTTACCTATTGATATAGAGTGGAAGGTAGGCTTTGGAAAGAAAATTAATAGAGTATGGAAAAATATAAGTATTATACGTCACATATTTAAAAAATATAAGATAGATATTGCTGTCAATGCCAATGCTCCTTTATTGATATGGATATTACCATTTATTTGTCGGCGGATAAAGAAGATCCATGAGTTTCATTTTTCTTATAAAGGACAACAGATATTAGATGAGGAAATTTTTAAATCGCGAGGAAAGAAATTTTTAGTTCAATATTTAAGAAAGTGTTGTTTGACAAAATTCGATAAGGTAATTGCATTAACAGAGTCTGACAAGAAAATGTGGAATTTACCGAATATATTTGTAATACCTAATTTTAGCAATATACAACTACATGAAAGAAATGGTAGAAAAAGCAAAGTTGCTATATCAGCAGGTAGATTAGAATCTGTAAAAGGTTATAATCGATTGATTGCAGCTTGGGTGATAGTTGCACAAAAGTGTCCGGACTGGCAATTGGAAATTTGGGGTGAAGGAAGTCTGCGAGAAAGTCTTCAACGACAAATTGATGCTTTGCATCTTTCATCAGTTGTTCATCTGAAAGGTGTTTCACCTAGTATAGGTGAAGTATATTCTCATTCTTCTTTTTTTGTCATGTCATCTTTGTATGAAGGTTTCCCGTTGGTATTGGTGGAGGCGATGAATTGTGGCTTGCCTTGTGTTAGTTTTGACATTACTGGAGCAAATAGTATCATAGACAATGGTAAGAATGGATTTTTAGTGCCGGATAATGATGTAAATGCCTTGGCGGAAGCTTGTATAAAATTGATAGGAGATAGAACGTTGTTGGAAAATATGAGTAAACAAGCTTACATTTCTAGTGCTCGTTTTTCTAAATTAAAGGTGATGCAGAAATGGTTGGATTTATTTCATGAGTTGTCGGAGAAATAAATGTTATAGTTGAGATTAGATATAGCTTTTATTTTTGTAAAAATGAATTATTAAAGAATGAATTATGCTTTTATAGACTCCATGGGGTCATTGACATACAATAATGGTATTAAAATTCAAGCCATAATGTGGAAGAATGGACTTGAAAAATTGGGGCACAACGTTAAATTGGTTAATTTGTGGGAGAATATTGACTTCTCAAGTTATGATGCTGTAATCATCTTTGCTATGGGGGCAAATATTTATAAACTGATAAAAGGTCTTTCTAGGATTAATGAAAATATCATAGTAGCTCCTATTATAGATCCTAACAGAAGTGATAGGTTTTATAAATTCTTGTTTAAGTTTTATGGTAGTACAAGATTAGCGTTATCCAATCATTACCATGATATGTGGTCTGTAAAGGAAAAGGTAAAGCTATGGCTTGTTCGTTCAGAACAAGAAAGACATTATGTGAGTTATTGCCTTGATATACCGAACGATAAAATAGCTAAAGTACCATTGAATTATAGAATTCCTGAGATTGGGCAATTAGGTGAAAAAGAGGATTTCTGTTTACATGTGTCTAGATTAGATGCACCTAATAAAAATGTTCCAAGACTTATTGAAGCGGCAAAAAAATATGGTTTTGATTTGAAATTGGCAGGTCATATATCTGGAGAAAAAGAAGAGAAAAAAATCATTTCACTTATTGGTAGTACAAAGAATATAGAGTATTTGGGAGAAGTGAATGAAGAGGAATTGGTATCACTTTATAAAAGAGCTAAAGTATTTGCTCTTCCTTCTTTAAGAGAAGGAGTAGGTATGGCAGCACTTGAGGCGGCTGCTTATGGATGTGAGATAGTTCTTACTTGTGTAGGTGCGCCTAAAGAATATTATGAGGGTCGTGCTTTGTTAGTTAATCCGCAAAGTATAAATGAAATAGGTGCTGCCATAATAAAAGCTATTAATAAAGGGTATTCACAGCCTGAGTTAAAATCTTATATAGAAAAGCGTTATAGTGAGAACGCTTGTTTGAAATTATTAAATGAAAATCTGTTGAAGTTGAATGAGTGTTCACTGATATGAAAACTGTTAAGTGTTTATATAACATTCTTATATCGTTTTAATATTGAATTTATAGTTATGGAAAATAAACTGGTTTCAATAATTATACCTGTCTATAATGTTGAAAAATATATTAAAAAATGCCTTGATACTGTTTTATGTCAATCACATCATAATCTTGAAATAATTTTGGTGGATGATGGTTCTTCGGATGCTTCAGGAATTATTTGTGATGAGTATGCCCAGAAAGATAAACGTGTAAAGGTGATTCATAAAGAGAATGAAGGTGTAAGTGTAGCACGAAATACAGGCATTGATATAGCTACAGGTGAATACATTTGCTTTTCTGATGCTGACGATTATTTGCAATTGGATTATGTTGAATACCTTTTGAAGATCGCAAATGAAAATGATGCTGATATAGCAGTAACAACTGATTGGTTTATTACCTTTTTAGGAAAAGAATTTCCGGAGGATTTAAGAGATATACCACTAGTTCTGAGTCCTGAGCATGCAGCAGCAGCCATTTTATATTATCATATTCCAATAGGATGTAACAGTAAAATCTTTAAGCGAAGTTTGTTAAATAATAAGATTAGATTCTATCCTCAGCTATCCGTAGGTGAAGGCTTTAATTTTAATGTAAAAGCTTTTTTATCTGCTAATAAAGTTGCTGTAACCAAAAGGCGAATATATTATTATCGTCGTAATAATCCTGCGAGTTGTATGACAAAGTTTAAATTAGAAAAATGTAATACAGCATTGTATGCCATTCAAATGATTAAGGATAATCTTATGATTAAATCAAATAGTTTAAACAGAGCATGTGATTTTGCGGATTGGCATACACATGGTGATATGTATAATTGGATGGTATTAGCAAAAGTGAAAGATATGTATCCAGATATGTATATGAGATGCTTCAATAAAGTACGTTCTTATTCATTTAAAGCGATATTTGCTCCAATAAGTAAAAAAGAAAAATTTAGAGCGATACTTCAGTTTATACATCCTAGATTGTTGGCATTTGTATTAGAGCTTAGAAGAGCTTATTATCAGCGGTAACTATATATTTATCTGAAATAAAGCGATGAAAGTAGCAATTCTCTCCATGCAGCAAATTAAGAACTACGGTTCTTTTCTTCAAGCCTTTTCTTTAAAAAAGAATATTGAGTCATTAGGTCATACCTGTGAATTTATAAATATTATTCCCGGAGAACAATTAGAAGGATATAAGACCAGTTGTTTTTACAATATTAAATTACTTTTCCAGCGCTTATGGGGATGGGATTTTTACAAACGTTTCCAAACGATATTTGTTTTTCAGAATCGTTTTCGAAAAGAGTTCCTACCTTATTTGGGAGTAAAAAAAGGAATAAATACAAAACATTATGATGTAGTGGTTATTGGAAGTGATGAAGTATTTAATTGTACTCAAAAGACTTGGTTTGGTTTTTCGTCTCAATTATTTGGGAAAGGACTGAATGCAAGTCGGATCATTACGTATGCAGCATCCTTTGGTGCGACTACTATAGACAAATTACAACTTGTCGGCAAAAAGGAAATTGTCTCAAGTTTATTGCATGATTTAGATGCCATTTCTGTGCGTGACGAGAATAGCATGAAAGTTATTGAAGAACTAACCGGTAGAACTCCTTGGCTTCATGTTGATCCAGTGTTGATGTTTGATTATAATCAATTTATACCTGATAAATTCAATAGGAATGAATATATAATTGTTTATACATATCCGGGAAGAATTACTGATAAAAAGGAAATAAGTTCTATCAGAAATTTTGCTAAATCAAAAGAACTGAAGTTGATATCAATAGGACATTATTTTTCATGGTGTGATGAAGTTGTTATTCCTACTCCGTTTGAAGTACTAGCTTATTTTAAAGGAGCATCTTATATTATTACTGATACATTTCATGGTAGTGTATTCTCTATAAAATTTAATAAAGAATTTTGTACTATAGTACGAGATATGAATAGTAATAAATTGGTGTCTTTATTAAAACAGTTTGGACTAGAGAATCGTATAGTTACCGATATGAATAAAATGCAAAAGATTTTGGAAACTCCCATTGATTATGCAGGTGTAAATAAAATAATAATGGAGGAAACAAAACGGTCTATTACTTATTTGACACAAAATATCAGATAATGAACTCTTTGTTAGTTACCTACATCTTGCAAACAGAGAAATGGACGTCTCCCGAACTTTTCGAAACGAAAAACAGAATTTACACCTTTCTCAACCCCGTATCTTACCTCATAGCTTTAGAAAACAAATCTTTATTTGAACAATTCGATGGTATTTTTGCCGATGGCTCTTTACTGGTTTCTGCCATAAGATTAGTATACGGAAAGCGAGTGACCAGACGTAGTTTTGATATGACCTCCCTTGCTCCCGAATTGTTGAATTACCTCATGGAAAGCCGTAAAACGCTCTATATCGTAGCCTCGGGTCAAGAACAAGTGGAGTGTTCTGTGAGGATATTTCAAGAGCAGTATCCGGAGTTACGCATTGCAGGGTTCAGGAACGGATATTTCTCTTCGAATGCTGAAATGAATAAGGAAGCTTCTCATATAGTCGAATTAAATCCGGATTTTCTGATAGTAGGTATGGGGGCCTTGATGCAGGAAAAGTTTCTGCTTAAGGTAAAAAAGATGGGTTACCAAGGCATCGGCTTTACGTGTGGTGGCTTTGTTCACCAAACGGCAATGAATAGGATGCACTATTATCCGAACTGGGTTGATAAGATGAATTTGCGTTTCGTTTATAGAATGTATAAGGAGAAACATACACGTACAAGATATCTGCAAGCTGCATTCTTGTTTCCGGTACGCTTTATCGGGGAAAGAATTTTCGGATGAAAGAGCAGACTTTGCTTATTGCCATGTAAATAATGGAGAATGGCAACAACAGGACGAAGATAGCAGTAGGAATAATTTTTCCGAGTATTTTTAATACATCTGTTTTCATGCTGCAAATATAAATTAAAATTCATAGAATAGTGAAATTAAGAACTCTAATATTTCTGGGGGGACTCTTTGGAGGAATGAATGTTATCAAAGGGCAGGCTTTTTATGGTACTACAGGACTACTTCATGCACCTACTGCCGTTATGCAGAAAGATAAAACCGTTATGCTGGGAGGAAATATGCTTGATGTAAATATACTTTCCCGATATTGGGTGAGAAGTGAATATCATCCCTATACCTATAACTATTATATAAATTGTACTTTGTTTCCTTGGCTGGAAGTAGCATATACTTGTACGTTGGTAAAGGGGATACATGGTTCTTCTTATTGGCCTCAGCAAACTTGGGGCAGGTTTACCAATCAGGACAGATCGTTTCATTTCCGGTTGAGGGCATGGAAAGAAGGCTGGTGGAAGGCTTGGACGCCTCAGGTAGTGATTGGTGCGAATGATCCGGGAAGCCATTCTTCAAATGGAGGTGGAGACATAGATTGGGGGGGCGGTGGTAGCGGAAACCACAATTACTTGACACGTTATTATCTGGCGGCAACGAAACATGTTGAATTTAGTGGAATAGGTACAGTGGGGGTTCATGTAGCTTGGGTTATCGGTAAAGCTATGAGTGATGTGCATTATAGCCGTCCTGCTGCAGGGGTAAACTTTCATTTTGGCATGAAGGGCGAAGGTTTCTGGCAGAAAGCTCTGAATGGATTTAATTTGATGGCGGAAGTGTGTCCCGGACATGCGGAAGATCTGCATACAGCAACTTATACTGTGAATGTGGGTGGAACTTATTCAATATGGAAAGACCATATCAATCTTATTGCTGAACTGAATGACGGTAAATTTTTTAGCGGAGGTATATTCTTTAAATTACATCTTAAATAACTGACTTGATTTCTAGTGGATGAAGCATTATAAGAATAGCCGGAATCACTTGGAAAAAGTAGTTCCGGCTATTCTTATATAACGATATTTGTATGTCCTGTTTTTATTATCCTACAATGTATTTAGCATTCTTGCCGCTTATTTTACGAATGAATACCACAAGCAGCCACGATACGCCAAATGCCACGATTGCGGCAGCGGGAATTTGTAAAGGCACGGGAACACCGATATTGCGCATCAGGACTACACCCGGACCTGTGAAAAAATAATGTATCATATAGATGCCAAAACCACATACGGTCAAGTTTGCCAGCATACGCTGGATCAGTTCTGAGCGTACTTTTACTTTCTTGGCTATGAGGAAGAAGGGGATAGTCATCATAATCACATTCAAAGAATTATAGGTGAAGAACAGTTCCAACATTTCATCAGTGCATTGTGGTAATGCGGTCATGTGGCGGAAACCGAAGAATGTGACCATGTAACCTGCCAGAAACATGGGGATACAGACTGACAGTGTCTTACTCCATGACCAGTCGTGGTTGCGCAGATAGTGTCCCAATAGCAAGTACCCGTTGAATCCGGCAAAATAATAGAGCATATTGAACGAGTTCCACGCACAGCCTCCCCAAATGTATGGGGATACGAACTGATAATAATAAGGTAACAAGCCGGTTATTCCCCATGCGACAAGAAACCATAGTTTGGCTTTCTCCGAGGCCTTTTCTACCCATGCGGAGAAAATAGGAAGGTATAGATATAATCCGATAAGCAGATAGATATACCACATATGTACGTCTAATAAAGAGAAATTGAGAGGCATTTCTGCTATATAACCCAATGATACGTTGAGTGACTGACGGGCGGCTTCTTCACCGCTATAAGGGAAAAAGTCAAGGATTATTTCAGGATTAAGTCCCAACAATCCTGTAAACCAGGGAAATAAATTATAAATGACACTCCAGATAAGGAACGGCCAGAATACACGGCTGATTCTTTTTTTGTAGAAAGCGGATATTTCGCCACGTACGGGGAGCAGCAATGCTCCTGTAATCATGACAAACAGTGGGACACACGGACGGAGAAAGGCTCCGTAGGCGGCTCCCCAGAATTTGATTTCATCAATGTTGGCTGGCGGTTCGCCGGGGTAAAAGTTGAACGGGTCTGCACTATGGCAGCAAACTACGGTGAACATGGCTACCAAACGAACGACATCCAGCCATACCACATGTTTTCTTGTGGTGTTCATAGCAATAGGTTGATTCATAATTTAATTTTTGATTTGACAGGCACAAAGGTACGCTTTCTCTGAGGATTATTTCTTGCTTTGGAACAAAAAATAAAAAGAACTATCCGCAATCATACTACAAAATGAGAATCCTCCCACTGCAAGAGTCACAATCATTTGTCTTTTGCAGGGGGAGGAATTCTATTTAGGGTTAGAGGGTTATTTTAGTCCTCTGTTCTTCAACAAGGGATCAATACCGGGTTCTTTGCCACGGAAATTGACATACATGTCCATCGCATCGTCAATGCAGCCGGGAGTGAGGATATATTTGCGGAACTTTCCTGCTACTTCTTGATTAAAGATATCGCCTGTTTCCTTGTATGCCTCGTATGCGTCACAATCCAGCACTTCTGCCCAAATATAACTATAGTAACCGGCAGTATATCCACCACCCATGGTGTGGTTGAAATAAGTGGTGCGATAGCGTGACGGAATTTGTTTCAGCAATCCGCGCTTACCTAATGTTTCTGCTTCGAACTGCATAACGTCCATATCATCGGGAATTTCTTTTAATACATGATAATCCATATCCAGCAGGGAAGCAGCTAAATATTCAGCCGTAGCGAAGCCTTGTCCGTATTTGCCACTCTTGTCCATTTTTTCAACCAGTCCGGCAGGAATAACTTCACCTGTCTGATAATGTTTGGCATATACATTCAATACCTCCGGTTCAAAAGCCCAATGCTCATCTATCTGTGACGGCAGTTCTACAAAATCACGCGGAACACTAGCCACACCATAATAATGTACATCTTTGAAAAGATTATGTAAAGCGTGTCCGAATTCGTGGAACAAGGTATTCGCTTCGTCTGCACTGAGCAAAGCGGGTTGTCCGGCTGCCGGTTTGGTAAAGTTGCATACCACGGTTACTACAGGAGCCACTTTCTTGCCGTCCTTGTAGGTCTGTGAACGATAGCTTCCGCACCATGCGCCACCTTTCTTGCTGGCACGCGGAAAGAAGTCCATATAGAGTACACCTAGATGAGAACCGTCTTTGTCCTTACATTCGAATGCCTGTGCATCGGGATGAGGGAGGGGAAGATTGTCCAGCTGGGTGAAAGTGATACCGTACAGTTTGTTGGCAACATAGAACACACCGTCACGTACGTTTTCCAGTTTCAGATAAGGACGTACCTGATTTTCATCCAAGTCGAATTTGGCTTTCTTGGCTCGGTCTGCATAATAACGCCAGTCCCAACCTTCGGCTGTGAAGGTTTTTCCGTCTTTCTTTATTTCGGCATTGATATCTGCCAGTTCTTCTTTGGCTTTGGACAGAGTAGGTGTCCAAATCTGATCTAATAATTTATATACGGCATCCGGTGTTTTTGCCATACGTTCTTCCAGTGCAAAGGAAGCATAGTTTTCATATCCCATCAGCTTGGCTTTTTCCAGACGGGCCTTGAGCAGTTTGCGCACCACTTCCTTGTTGTCGTATTCATTTCCGTTATTTCCTCTGTTAATGTATCCTTTGAATATCTTTTCACGCAGGTCTCGGTTATCGGCATATTGCAGAAAAGGCATGACGCTGGGATTATGCAGGGTGAAAATCCATTTGCCTTCCATGCCTGCTTCTTTAGCTGTTTCGGCAGCACTGGCAATCAGGTTTTGGGGTAATCCGGCTAAGTCTTCTTCTTTGTCCACGATCAATTGGAAAGCATTGGTTTCCTTTTGCATATTTTGGCCGAAGGTGAGCTGTAACATGGAAATCTCACTATTTAATTCCCGCAGTTTTTTTTGACTGTCGGCATCCAGGTTGGCACCTCCACGTACAAAATCTTTATAGGTTTCTTCCAACAACTTCTTTTGCTCTTTGTCCAAATTGCCGGGATTTTCATAGACAGCTTTGATGCGTGCAAAAAGTTTTTCATTTAAGGCGATGTCATCGCTGTGTTTTGATTGTAGTGGAGAGAGTTCACGGCTCAGTGCGTCCATTTCATCATTGGTATTGGCGCTTTTCAGTCCGTAGAATACGGTGCTGACTTTACGAAGTAACGCTCCGCTTTGATCCAGTGCTGCAATGGTATTCTGGAAAGTGGCGGGTTCGGGGTTGTTCACTATAGCGTCAATCTCTTTCTGTTGTTCTTCCATGCCCTGCAAAAAGGCGGGTTTGTAATGTTCCATCTTGATTTGGTCGAAAGGAGGAACCTGGAAGGGAGTTGTGTACTCTGAAAGGAATGGATTTCCGGTAGGGGCTGCCTGTTTCCCTTGCGAACCGCAACCGCTTAATATGGCAACCGCACAGGCTGCCAAAAGAATGTGTTTCATAATAATTTGTTTTATATAGGTGATAATGCAAAGATAGTAAAATAAGGCAAATTCCAATAAGTTTGAAGCGTAGAACTATTTGTTTGTTTTCATAGTCTGTCTAATTATCATACATCATTGTCTAATAATTAGACAGACTGTTTCTTTTTGTTATTTTGCAATGTGTTGTTAATCAGTTATTTGTTTGCGTGGCACGGTTTTGGCATTTATATTATAGAGAACGAATTATAGAAACTTTAGTTTCTTATACACTTTATGGGAAGTAACGTTGTGAAACGGGACTTCTCTCTTTTAAAATAATAATAATTAAAAACACGAAATATGAAACAGATTTATTATGTCATTCAGGCTTTGATACATGGACGTGGAGCTAATATTATAAAAGTCGTTTCGTTAGGCTTGGGCCTGACTATGAGTATTCTGCTTTTCTCAAGAGTTGTGTATGAGCAGAGTTTTGATACTTGTTTTAAGGATCATGATAAATTATACCAATTGTGGAATATATGGACAGTAAATGGAGAGCCTTTTCCTCCGAGTGAGTTCATTATCGGTGCAGCTGCCGGAGGCATACTGGATGCAATGCCGGAAATTGTGGAATCGGCGGCAAGTACAGGCTCGTGGCCGGTTTCGGCACCTATTTATAACGGGAGTGTCCGCTTTGATGATTTTAAAGTTGCTGCTGATTCATTGTTTTTTCAGACAATGGGTATTGAGGTCTTGAGTGGTGATCCGGTACGTGAATTGCAGCAAAAAGATGTAATTTTCCTGAGTAAAGATTTGGCGGATAAAATGTTTGGCGGTGAGAACCCGATTGGTAAAATAATTAGTTTCAATAAGGAAATTGAGTTGACAGTCAAAGGAACGTATGCTGCTTTACCTGAGAATTGTACTATGCGACCGAAGGCTGTCATTTCCTTGCCTTCTATCTGGAGCCGCCGGATAGGAAATTATTCATGGAACGGTGGGGACAGCTGGAAGGAATATATCCGGTTGAAGCAGGATATTGATTTGGATGAATTGAACAAGCGTATTGATATGGTAGTACAGCAACATATTCCCAGAAGTGATAAGTTGGGAATCACTGTCATGGCAAAACCTGTTCGGGATACGTACCGTGGATATGATGAAGTGAAAAGAATGCGTAATATTATGCTTATTTTAGGTATATCTATTTTGTTTATCACGACATTGAATTATGTGTTGATTTCTATTTCTTCATTGAGCCGGCGTGCCAAAAGTATTGGTGTTCATAAATGCAGCGGAGCGGGAACGGGTACTGTTTTTGGTATGTTTATGTGGGAAACCGGTATTATTATTTTGCTTTCATTGTTTTTGATGGTTTTTTTAATGTTTAATTTCCGGGAATTTGTGGAAGATACTACAGCTGCTAAACTGGAGTCTCTTTTTGCGGTGGAACGTATTTGGGTGCCTTTTGGAGTGACTGCTGTCTTATTCCTCATTGGTGGTGTGCTGCCGGGACGAATTTTTTCAAAGATACCGGTCACACAGGTTTTCCGGCGTTATACAGAGGGTAAGAAAGGATGGAAACGTCCGTTATTGTTTATCCAATTTGCAGGAGTGGCTTTTATATGTGGATTGATGTGTGTAGTGATGCTCCAGTATCATTATGTTATTAATAAAGATCCGGGTTATAATCCTGAGCGGGTAGTGATTGGCGTTAATAATGCACCGGATGCTAAAGCCCGGCTTGCTGCCCGTCACTTTTATGAGGGGCTTCCATACGTGGAAGCATTGACTTCGGCAACTAGCTATCCGTCTAATGGATATAGCGGGCAGATGATACCGGATGAGAAAGGAACGAGTCTTTTTTCCAGCCGTTATGATTTTACTCAGGAGAATTATGTAGCTTTTATGGGAATGGTCATACAGCAAGGGCGTGTGCCTCGTGAATCCGGTGAGGTGGCAGTGAATGAGGAATTTGTACGGAGAATGCATTGGGGAAAAGATGTTTTAGGTAAGAGTATACAGACAGAAGAAGGCCGTGTCAAAATAGTAGGTGTGATTAAAGATTTTAATATTGGCGGATTCTACTCAGAGCTGAAACCGTTTGTCCTGCATCATCATCCCAAAGATTTGGCTGATCTTGTTTATCTCCGTCTGAAGGAACCCTTTGGTGAGAATCTTCAGAAACTGAAGCGTGATGCTGCCGAAGCTTTTCCTAATCAAACAGTCGGCTTTGAAAGCTTGGAACAAAAAATGGCGGATAGTTATAATTCCGTTCGTGTATTTCGTAATGCGACTTTATTGGCGGCAATTGCCATCTTGTTTATTACTTTGATGGGACTGATAGGCTATATTAATGATGAATTACAGCGACGTTCGAAAGAAATTGCTATTCGTAAAGTGAATGGAGCTGAGTCATTTGCGATATTGGAAATGTTGGTGCAAGATGTTCTTTGGATTTCTTTCCCGGCTGTAGTCGCAGGTACACTAGGGGCATGGTATGTAGGTGGTTTATGGATGGAACAGTTTGCTGTGACTGTAGGTTCGCTTGTTCCTTATTATGTATGTGTAGCTATCGTGGTCTTGATATTGATTGTCAGTTGTGTCATTTCCAAAACATGGCGCATTGCCAATGAGAATCCAGTAAAGAGTATTAAATCAGAATAAAGATCAATAGAACAAACAATTAAAATTTATTATTATGATACAGATTGAAAATTTAAGTAAGGTATTTCGTACTTCAGAAGTAGAAACAATTGCGTTGAATCATGTAAACATAGAGGTGAAAGAAGGAGAGTTTGTAGCTATTATGGGACCATCAGGTTGTGGAAAATCCACCTTATTGAATATCCTTGGTCTGCTGGACAATCCTACTGAAGGCAGTTACAAGTTGCTGGGCAACGAAGTAGCCAATCTGAAAGAAAAAGAACGCACCCGCCTGCGTAAAGGTGTAATAGGTTTTGTATTTCAAAGCTTTAATCTGATAGACGAACTGAATGTTTTTGAAAATGTGGAATTACCGTTGACTTATCTTGGAATCAAGGCCAGTGAACGTAAGGAGCGTGTTCTGGAAATTTTAAAGCGAATGAACTTGAGTCATCGTGCCAAGCATTTCCCGCAGCAGCTTTCCGGCGGTCAACAACAGCGTGTGGCTATTGCCCGTGCTGTGGTTACTAACCCTAAATTGATCCTCGCCGATGAGCCTACCGGTAATTTGGACTCAAAGAACGGTGCTGAAGTAATGAATCTATTGACCGAACTTAACAAGGAGGGGACTAGTATTGTCATGGTAACTCACTCTCAGCATGATGCCGGATTTGCTCATCGTGTCATTCATTTGTTTGACGGTAGTGTAGTGGCGAACATTAAAGAATAATAATGAAAGGGTGGTTGTAATGAAACAAATCTATTATGCAATACAATCGACATTACACGGCCGTGGAAGCAATGTGACAAAAATCATATCGCTTTCATTAGGCTTGACTATTGGTGTTCTGCTTTTTTCACAAATAGCATTTGAACTCAATTATGAAAAATGTTACCCTGATGCCGACCGATTGGTGTTGGTACGTGGAGGAGGAGAGAATGTAAAGACTGGAGAGAAAGGAGAAGGATATGATGATAGCTTGTTTGCTCCGATGGCAGAAGCATTCCGCAGTGATTTGTCACAATGGATTGAAAATGCTACAGTCATTTTCAATTTTGAGACATTAAATGTATTCAAGGATGGTCATAAGCTGAAAGACGTAAACTACGCTTATGTAGATACTTGCTATTTCCGTACTTTCGGCATCAAAGTATTGAAAGGGAATCCTGAGGAATTGCAAAGGGCAGGGAGCATATTCGTTTCTGAAACTTTTGTTCGTGATGTCTTTGGTGGACAGGACCCTGTGGGACAAAAATTATCTTTGGATAAACAGCATGAACTGACAGTCCGTGGTGTTTATCAGGATACTCCGGAAAATACGGCCTATCATTTTGATTTTGTAGCTCCCATTTATGCCGGAGGTGGTTATATAGGGGGTGGAACATGGGGGCGTAATGACATTTATTATACTATTCTCCGTTTGCGCGATGGGGTGGACAGGGAAGAAATCAATCGTCAGATATACAAGGCTATGCAAAAATATTATCCTGATTCTGCTGATGATGAATGGAGAAATTTTTATGATGCACAGCCATTGCCCGAAATTCATCTGGATGACTCAAATACCCGCACTCGCCTTTACATTTATGGTTTTTTGGGCTTTGCCATATTTTTTGTGGCAATCATGAACTATGTATTAGTAGCTATTGCTACCATGAGCCGCAGGGCAAAAAGTATAGGTGTGCATAAGTGTAGTGGTGCCAGTGCAATCAATATTTTCAGTATGTTCCTTTTTGAGACGGGGATTGTGGTATTGATGTCCGTTATAGTGGCCCTCTTTATTATTTTCAATACCAAAGATCTGATAGAAGATTTACTTTCGGTGCAGTTATCCTCACTCTTTACATTGGAAACTTTATGGGTTCCGATGCTCATTGTTTTTGTACTGTTCATAGTAGCCGGAGTGCTGCCGGGAAGATTGTTTTCACGCATTCCTGTCACTCAAGTTTTTCGTCGTTACACAGATGGGAAAAAGGGGTGGAAGCGTTCTCTTTTATTTGTACAATTTATGGGGGTATCTTTTGTGATGGGGATTTTGTTAGTATCTTTGATGCAGTATCATCATCTGATTAATAGTGATATGGGTATCCGTACTCCAGGATTGGTGGAGGCGGAAACATGGATGTCACCCGAAGAAGCAGAGAATATGGTTAACGATCTTCGTCGTCAACCCATGGTGGAAAATGCCACCCGTTCTATGCATGGTGTTCTGGGAGAATATTGGACTCGTGGGCTGATTGATAATAGTGGCAAGCGAATAGAAACCTTGATGTATAATCCTTGTGATAAGAATTATGCTGAAACCATGGGGATTACTATTATTGAAGGGAAAGATATGCAGAATGAGGGAGATGTATTGGTCAACGAAGAAGTAGTGCGGCTGATGAAATGGACAGATGGGGCAGTAGGCAAACGGTTGAATGATTTTGATAAAGCCGGAACCATTGTTGGTGTATTCCGTAATGTGCGCAATACGTCTTTTCTTTATAAGCAGTTTCCCGTGGCTTTGGTTTATAGTCATAATACCAGTCACACTTTTGATGTACGTTTAAAACAGCCATACGATGAGAGTTTGAAAAAGCTGAACGAATACATGGAGCAGGTGCATTCCACTAAGGCATTGGAATTTATTCCGATAGATACCATGCTGAAGGAAATCTATCGCAATGTATATCGTTTTCGTAATTCTGTATGGATTACTTCTACTTTTATTTTGCTTATTGTTGTTATGGGGTTGATAGGTTACGTGAATGATGAAACACAACGTCGCAGTAAGGAAATAGCTATCCGTAAGGTGAATGGTGCTGAAGCTTCGACTATTCTTCGGTTGCTGTCCCGTGATATATTATATGTTGCTGTCCCATCGGTCTTGATAGGAATTGTAGTATCGTACTTTACAGGAAAGGCTTGGTTGGATCAATTTGCCGAAACGATAGATATGAATGCGTTGTATTTTGTCGGAACAGCATTGGTGATTATCGCTCTGATAGTGGTGTGTGTCGTTGTTAGAGCTTGGCGTATTGCTAATGAGAATCCGGTAAAGAGTATTAAAATTGAGTAACTAAATAGATAGCGATGAAGCAATTATATTATGCAATACAAACGATATTACACGGTCGTGGAAGTAATGTGACGAAAGTCATATCGCTTTCATTGGGGCTGACTGTTGGCATCCTGTTGTTCTCGCAGATTGCATTTGAGTTAAGTTATGAAAAATGTTATCCTGAAGCTGGAAATCTAGGAATAGTCCGCGCATATTACCATAATTTGGAAACAGGTGAGTCGATGGGGGACGATGGGGATATCTATGATTATTCCGTTTTTGCTCCGATAGCGGCGGCTTTGGCTGAGAATATGCCAATAGAAGTGGAAAAAGCTACTTGTATAAATTCTTACACAGCCAACGGTAATTATTATTATGAAAATCAATTGTTGTCGGATGACGAACAGTGTCTTATGGTGGATACTTGTTTTTTCCAAACCTTTGGCATTCCGGTTTTAAAGGGAAATCCTAACGATTTGATTAACTCCAATACTTTGTTTGTGTCCGAGAGTTTTGCACGCCGTTTTTTGGGTGATGCAGATCCTATAGGTAAAGTGTTAATGTTGGAGCGGAAAACTGAAATGATTGTCCGTGGTGTTTATCGTGATATTCCGGAGAATACCATGTTTAAGGCAGACTTTGTAGTAAGTGTACATAAAGAAGGAGGTTATAAGGATGGAGCCGGATGGGGAGGAAATGATATTTTTTATGCAGTGTTCCGGACCGGAGAAGCTTCGGATATAGAGGTGGTAAACGATAACATCCAGCGGATGGTGGAGAAATACATGCCGACTGAACATAACGGTTGGAAACTGGAACTCAGTGTCATTCCATTGGCAACAAAGCATCAGACTTCTTCAGAAACAACAAAGCGTCTAGTTATCTATGGCTTTTTGGGTTTCTCTATCTTCTTTGTCGCTATTATGAACTATATGCTTATTGTAATTGCTACTTTGGGACGTCGTGCCAAGAGTGTCGGTGTCCATAAGTGCAATGGTGCCAATAATGGGAATATCTTCAGTATGTTTATGATGGAAACGGGCATTATTGTTCTGGTATCCATTCTGGTCTGTGCATTTATCATTTTCAATGCGCGGGATTTGATAGAAGATTTGCTGTCGGTGCGACTTGCATCACTCTTTACATGGGGAACTTTGTGGGTACCGCTGCTGGTTGTTGTACTTTTATTTTTGTTGGCAGGTGTATTGCCCGGACGTATTTTTTCACATATTCCTGTCACACAGGTATTCCGTCGTTATACTGATGGTAAAAAAGGATGGAAACGGTCACTGTTGTTTATACAGTTTACCGGTGTGTCTTTTGTCTTGGGATTATTACTGGTTACGTTAATGCAGTATAGTCATTTGATGAACAGGGATATGGGGATCAATACTGCCGGACTGGTAGAAGCCGAAAGTTGGCTGGACATTGAAATTGTTCCTCATATGCGCGATGAGATCCGGCGTCAGCCTATGGTAGAGAGCGTGGCTACAGCCAGCCATAGTGTATTGGGCCAATATTGGACAAAAGGATTGATGGGCAGTGACGGCAAGCGTATAGGTGTTCTTAATATGAACTATGTGGATTTTAATTATCCGGATGTGGTAGGCATTACGATTATAGAAGGAAAGCCGATGACCCATGCCAAAGATCTGCTGGTGAATGAAGAGATAGTCCGGCTTAAGAAATGGACGGATGGAGCCGTAGGAAAACCTTTTGATGAGATTAAGGAAGGAACTATAGTAGGTGTGTTCCGTGATGTGCGCAATCAAAGTTTCTATCAGGCGCAGCAACCCATTGTGCTGATAGGTGGTAATGCGTTTAATCATACCTTCAATGTACGGTTGAAAGAACCCTACGATGAAAATTTGAAGCGCCTGAATGAATTCATGGACAAAACTTTTCCACAAGTGGCTTTAACATTCCATACAGTGGATG
+>3_1#NODE_8_length_39997_cov_62.8364_ID_15
+GGGACAAAAACGCCGTGTTTATCGCAGCTTGGTTAGCTGAATTCCAAAACTGCACGGACTATTGTCTTATGTCAAATGCTCTAATTACGCCAGAGCGAATTGCTCTTGCGCCGCGAGCAGGCCGCTGAGCTGCTCGGCGGTGAGCGGGTAGGAGAGCGCGTAGCCCTGCCCGAGCGGGCAGCCGAGTTGGCGGGCGGCCTCGACGACCACTCAACCGCTCTTATCTCGCATCCTGCCCCGCAGGATGCACCGCACTACCCTTCGCCCTTCACGCCTCGTCTTGCATTCTGTTGATTTTGAGCAGCATCACAAATGTAGACACCCCCGTGCCCATAGCACTGTGGAACCACCCCACCCCATGCCGAACTGGGTCGTGAAACACAGCAGCGCCAATGATACTCGGACCGCAGGGTCCCGGAAAAGTCGGTCAGCGCGGGGGTTTTTTCGTTGCGGGAGTAGCTCAGCTGGTAGAGCACTACCTTGCCAAGGTAGATGTCGCGAGTTCGAATCTCGTCTCCCGCTCCATCATCCCCCCTTCGCCTCTTCCGAGGTGGAGGGGCTTTTTTGTTGGCTTGCCGCATTTCTATGAACCAGTGCGGCACAATAACAGCTGTGTTTGAATTTGAAATCAAGCAGCGTGATGGACGTGCCCGCACGGCGACGTTCCAGACGCCGCGCGGAGCGGTCACCACACCTATGTTTATGCCCGTCGGCACCCAGGGCACCGTAAAGGGCATCAGCCCACAGGAACTGCTGGAAATCGGTTCGCAGATGATCCTGGCCAATACCTATCACCTGATGCTGCGGCCAGGAGAGCAGCTGGTCAAGGCGCATGGTGGTTTGCCGGGATTCACCGCCTACCCAGGCCCCTTTCTGACTGACTCAGGCGGTTTTCAGGTCATGAGCCTGGGGCACATGCGCAAAATCAGTGAGGAAGGGGTCGTGTTCAAGAACCACCTTGATGGCAGTCGCGTCGAGCTGACGCCGGAGCGCAGCATTCAGGTGCAGGAGGCCCTGGGAGCAGACGTCATCATGGCCTTTGACGAGTGCCCTCCCTATCCTGCCGAGCGGCCTTACATCGAGGCGAGCCTGGACCGCACGGTGCGCTGGCTCGAGCGCTGCCACGCGGTGAAGACTAAAGATGACCAGGCCCTCTTCGCCATCGTGCAGGGTGGCGTGCATGAGGATTTACGTCTCAAGAGTTTAGAGGCCACCCTGCCTTTCGCCACGCCTGGGTTCGCGGTCGGCGGCCTGGCGGTCGGGGAAAGCAAGGAAGAGATGTATCCGGCGGTGGCGTTTACAGCCGGCCGTCTTCCCGAAAATAAGCCGCGTTATTTGATGGGTGTGGGCCACCCCGAAGACCTTGTGGCAGGAGTGGCACTGGGAATCGACATGTTCGACTGTGTGTATCCGACACGGACCGGGCGCTTCGGCTACGCGCTGACGGACGACGGACGGCTCAACCTCAACTCCAGTGCGCCGCGCACCCAGCTCCAGCCCATCGACGCGGAATGTGACTGCTACGCCTGCCGTCATTACACCCGCGCTTACCTGGCGCATCTGCTGAGAGCGGAAGAAATGCTGGCTCCGCGCATGTTGTCGCTGCATAACCTGCGGTATCTGCACCGGTTGGTCGAGCGAATGCGAGTGGCGATCAATGGGCAGCAGTTCCATCCCTGGGCAGCAGACTGGAGCGAGCGTTATTTTCACGGCAATGTCCCAGGCTGGTTCACCAGTGCGTTTGAGCGCAGTACCCAGTCCGAAATTTAATAAGACGGACTCGCTGCGGCCTTTTCGGCGTCACTTAAACGGTCAAAGTTGAAAATGAGAAGAAAATCTGATGGTCAACTGACGGAGAAGGGGCGAAAACAGTTTATTTGACGGTATTTAGCTCGCTCTTAGGGTTGACCCGCCCATCTTCATGCTTGTATCATCTGCACGATCTGCCCTCTTCTGTAGCCACAGGCTGCGAAGGGTGGGTTGCGCGAAGAAGGCGGAGTAAGGCCCAACTTCTCCTGGGAGAGGAAACATGGCAACTCGCCCCATCAACATCCTGCGTGCTGGAAACGCTGCTCGACGCGCACTGAGATTGGGGGTTCCCTATGAAGAAAAGTCTGATCGCTCTTACCACGGCGCTGTCGTTCGGCCTCGCTGCCGCCCAGACCGCCGCACCGGTGAGTGCACCCCAGGTTCCCGCCCTGACCGACGTTCCTGCCGGCCACTGGGCGAAGGACGCCATTGACCGTCTAGTGAGCCGCGGCGTCATCCTGGGCTACCCCGACGGCACGTTCCGTGGCACCCAGAACCTGACCCGCTACGAAGCCGCCATCATCATCGCCCGTCTGCTCGACCAGATGCGCGACGGCGAAACCCCCGCTGGCATGACCGCCGAGGACATGACCGCGCTGCAAAACGCCATTCAGGAACTGGCCGCCGACCTGGCCGCCCTGGGCGTGCGCGTCAGCGACCTCGAAGCGAACGCCGTCAGCAAGGACGACTTTGCCCGCCTGGAAGCCCGCATCGAAGAAGTGGCGGCTGCTGGCGGCGAGCAGGGCGCGACCGAAGCCCTCCAGGGCCAGATCGACGACCTGACCGCCCGTGTGGACGAGTACGACGCGCTGCGTGCCGATGTCGACGACAACGCCAGCAGCATCGCTGCCCTCAACGACCTGACCGTGCTGCTCAACCAGGACATCCTGGACCTGCAAGACCGCGTCAGCGCCGTGGAAGCCGCGCAGGCCGACTTCGTCCAGCGCAGCGACTTCGACGCCCTCGGTGGCCGCGTGACCACCGTCGAAACTCGCGTCGAAACCGTCAACAACTCGCTGACGGGCCGCATCGCTGCCCTGGAGCGCAACGCGTTTAGCGTCAAGCCCAGCCTGACCATCGGCTACAGCGTGAGCCGCACCAGCCGCAACTTCGACGTTGACCGCCTGTTCCCCCTGAACGCGGACGGCACCGTGGCCAACAACGCCTTCACCAGCGGCGGCATCGACACCGACACCGGTGCTCAGCGCCGTGACTTCGGTGACTTCGGCAACGCCTCTGACCCCGTGGTCGCGGGTGCGGCGGGCCTGTACGGCTTCGCGGACGGCGTGAGCTACACGGTGTACTTCACCGACGGCTCCACGGCGACCTTCGACGGCCTGAACCCCGCCGATTACAAGGTCCCCACCGGGAAGGTCATCGATACCACCAAGGGTCGCAACGGCTTCGGCTTCAACAACCTGGCCCGCTACAAGGAAGGCAGCACCGACATCGGTATTAGCCTGGGCTTCGACACCAGCGGCCAGTTCAGCCAGGTCACCAGCGGCACCGGTGGCAGCCTGTTCAGCACCGCGGGCCGTCTCCAGGTCAACCAGATTGACCTGAACTTCGGTCTGGTCACCGGCCTGCCGAGCGACGCTTACGTCGACACCAACGGCAACGGCAAGAAGGACGACGGCGAGGCGACTGGCCGCGGCACGTACCTCGGCAGCGGCGGCACGGCGGCCATCCTCCGCGATCCCGCTGGGAACGTCTACCGCCCCGTGTTCTTCCGCTTCAAGAACGCCACCACCCAGTTCAGCGTGGGCAACAACCCCGTTATCGTGACCTTGGGCCAGCAGCAGAAGTTCTACTTCAGCGACTACGTCTTCGACAACAACTACGATGGCCGTGGCGACGGCTTCACCGTGACCGTGGACGGCAGCAACGTGCCCGTGATCGGCGCCTGGAAGCCCCAGATCAAGGGCGTGTACGGCAGCCGCAGCGGTCTCGACGGCACCGCCGAAGCCGGCTACGGCGTGTACTACCGCGGCGTGCGTGCGCAGATCACCCCCGTCGGCACCCTGACGGCGGGCATCCACTACGCGCAGGAAGGCCGCGACATGTTCGGCGCAGCTCAGAACACCACCAGCACGCCTTCCGACGTCACCACCTACGGCGCCGACCTGCACGGCAAGGCCTTCGGTGTGGAACTGCACAGCGAGTACGCCACCAGCCGCGTGCGCCCCAACACGGCCAATGCTGCCGTTCAGACCAGCAACGCGTTCTACGCCCGCGTGGCGACCCGCAAGGACAACCTGGCGTTCGACCTGAACACGCCCGCCGCCAAGTTCGGCAACGACACCTTCGGCGTGTCGCTGTACGACCTGAACTACCGCAAGATCGACGCGGGCTACAACAACGTGGCTGGCATCAGCGAGTATGGCTACGGCTCGTACAGCCGCACCTCGGCCCAGAACATCGCCTACAACCCCGACACCGGCGTGACGGCTCCCTTTGCCAACCTCGACCGTCAGGCCTACACCGACGCCAATAACGACGGCACGTCTGACCGCAACGCTGACGGCACCGTCGTTGCAACCAACACCAAGATCGGTCAAATGGGCTTCGGCGTGAAGGCAGCGGCCAACCTCGGTCCCGTGGCCATCGGCGGCTACTACGACACCAGCACCGGCGCCAACGGCGACAATGCCAACCGCATGACCGAAGCGGGCGGCTCGGCCAAGGTGGCCTACAGCATCTTCTCGCTGCGTGGCACGTACAACACCCTGGACAGCAACCGTCCCCAGATCTACCGTGACGCCGCCGGCACCCAGATCATCGGCGACGCCAAGGTGCGCCGCTACGCCGTGCAGGCGGACGTGACCCCCGGCCTGGGCCTGTTCGTGGGCGCTTACTACCGCGACGTGAACGTCAACGGTGTGCGCTCGACCACCGACCGTGGTCTGCTGGGCCGCGGCTACCTGGCTTCCAGCTTCGAGCCCGGCGTGGGAAACAATGCCTACCGCACCGGTCTGCGCTGCGCCGACAACAACTTCGGCACCGGTACCCGGGACATCGACGGTGTGGGCGGCGTGCTCAACCCGGCGGTCAACCTCGACCAGAGCCGCACCGCCACCTGCTTCACCTCCTACGGGGTCGAAGCGGGCCACGCGGGCGACAACGCCAACGCCCTGGTCAAGGACCTGTTCTTCCGCGTGGGCTACTCGCGCGTGTACGTGCCCACCACCGCCACCGCGACGACGGGCGATTTCAGCGGCTCGGTGACCTACGGTGACGCCCGTTACGACCGCAAGGTCGGCGTGGCGAACGTGCGCCTCGCGGGCTCGTTCTCGACCACCAACACCCAGCTCGACAGCCGTCCTGCCGGGACCCGTGGCGCGGTCGGCCTGATTGTGCGCACCGATCCCCTGGAAAACGTGCCCTTCCGTCCCCAGTTCAACGGTCAGGTGGGCTACTACACCGCCGACAACCGTGTGGCCGCTGGGAACTACAACGCCAACGCGACCAAGTACGGCGCGGGCGTGGTCCTGAACGACTTCCTGCTGCCCCAGACCAAGATCGGCGTGCGCTATGACGGCTATATGGCTCAGAACCGTCAGTACACCCCCTTCGACGGCGACGGCACCCAGGGCTACTTCAGCGACGCCAACAACAACCGCCGGACCAACCTGAACGGCGTGTACGTGGAAGGCGCCTACCAGGACCTGATCTTCAGCTACGGCACCTACACCCTGAGCCAGAAGGATCTCAACGGCGTCGAGTACGGCAGCGGCATCAACAACGGCCAGCCCGCTCGCGGCCAGACCTTCAAGATCAGCTACAAGGTCAACTTCTAAAGCCCCTAGTTCCCGGCATTGCCGGGCAACGGCCCCCGCTTCGGCGGGGGTTTTTGTTGTTCTGTAGTTAGTTCCGGTGCGGCGCGGCCAAAGTCGGTAGACTGACGCCATGCTCGCTGTTTTTGGACACCTCAACCCCGATACCGACGCCATTTCGGCGGCGATGGTCTACGCCCGGCTGCTGACGCGGCAGGGCACCGAGGCCCAGGCTTACCGGCTGGGCGAACCGAACTTTGAGACGGCCTATGTGCTGCGTGAACTGGGCCTGGAAGCGCCGCCACTCCTGACCGAACTGCCCGCCGGCAGCAAGGTGGCGCTGGTGGACCACAACGAAAGCGCGCAGTCGCTGCCCGCCCTCGGCGAACTCGACGTGACCCGCGTGGTGGATCACCACAAGCTGGGCGACCTGACGACCATCAACCCGCCCTACCTGCGCTTCGAGCCGGTAGGCTGCACGGGCACCATCCTGCTGAAGCTGCACCGCGAGGCTGGCCTGAGCGTGGAACCCCAGGACGCCAAGCTGATGCTGAGCGCCATTCTGAGTGACACCCTGCACTTCCGCAGCCCGACCACCACCCAGGACGACCGCGACGCGGTGGCGTTCCTGGCCCCGGTGGCCGGGGTAAACGACGTGGAGGCCTACGCACTGGCCATGTTCGCCGCCAAGAGCGATCTGGGCAACACGCCCGCCGAGACTCTGCTGCGGATGGACTACAAGGTCTTTCCCTTCGGGGACCCTGTGCAGCCGCAAAACTGGGGCATCGGCGTGATCGAGACGACCAACCCGGCCTACGTGTTCGGGCGGCAGCAGGAACTCCTCGCAGCGATGGATCAGGTCAAGGCCGAGGACACCCTCTCGGGCATGTTGCTGAGCGTGGTGGACATCCTGAACGAAACCAACCGCACGCTGGTGCTGGGCGCCACCGAGGCCAAAGTGCTGCGCGAAGCCTTCGGCGCCGAAGCTGAGGGACAGGTAGCCGATCTGGGCAACCGCATCAGCCGCAAGAAGCAGATCGTGCCGACGCTGGAAAAATACTTCGCGCCCGAAGCCTGAGCGGGCTCTTTCAACAGGGGAGACGGGGAGCACCTCGTCTCCCTATTTACTTGCACAGTCCAGAGCGGCGGTATGCTCCGCGCGTGACGCAGGACACGAATGTGGAATGGCTGTTCGCCCGGCAGCGGTTCGGAGTGCACCCCGGCCTGGACCGGGTGCGCGAGCTGCTGGCCCGGCTCGGCGACCCGCAGCGGCAGTTCGGGGCCGTGCTGGTCGGCGGAACCAACGGCAAGGGCAGCACCGCCGCCACGCTGGCCGCCATGCTGCGGGCGGACCGCAGACGCACCGGCCTCTTCACCAGCCCGCATCTGACCCGGCTGAGCGAGCGTTTCGTGGTGGACGGGGAGGAAGTCTCGTCGGCGCAGGTCACGGCAGCGCTGGCCCGCGTGCGCCCGGTGAGCGAAGCGGTGGAGGCGTCTTTTTTTGAGGTGGTCACTGCGCTGGGGTGTGTGCTGTTCGCCGAGGCCGGAGTAGAAATCGCCGTGATGGAAGTCGGGTTGGGAGGACGGCTGGACGCCACCAACGCGCTGGAGCCCCGGCTGAGCGTGATTACCAATGTGGCACTCGACCACACCGCCATCCTGGGCGGCACCGTCGAGCAGATCGCGGCGGAGAAGGCGGGCATTCTGCGGGCCGGGCGACCTGCCGTGACGGCTGCCGCGCCCGCCGTGCTGCCCGTGCTGGAGCAGCGGGGCGCCGATCTCTGGGCGCTGGGTCGGGACTGGACGGCGCAGACCCGCAGCCTGGGCTGGCAAGGTACGGCGGTCGACGTGCAGTGGCCCGGCGGTGCGGCGCAAGTGCAGACCCCGCTGCTGGGCGAACATGGGGGCCTCAACGCGGCGCTCGCGGCAGTGGCGGCGGCGCGGCTGGGCGTCTTTAATGAAGCCATCCGGCAAGGAGCCGCGCAGACCCGCTGGCCGGGGCGGTTGGAGGTTGTCCCCTGGCAAGGGCGGCGGGTACTGCTAGACGGGGCCCATAACCCGGCGGGAGCACAGGCACTCGCGCAGGCGCTGCGTCCATTGCTGGCGGCGAGTGGCCGTGCCCAGTTGCCCATCATCTTCGGGGCAGCGGAAGACAAGGACCTGGGCGGGGTCGCCGCAGAACTGCTGCCCCTCGCCTCACGGGTCATCCTGACGCGGGCTGCGCTCAGTCCCCGGGCCGCCGACCCGGCGCAGCTCGCGGCTCTGTTTCCAGGCGTGCCATTGGAGTTGACCCAGACGCCCGCCGAGGCGCTAGCAGTACTGCGGTCTGACGATGACCTCGTCCTTATCTGCGGGAGCCTCTATCTGCTCGGCGAACTGCGTCCTTTGCTGCTGGGCGAGCAGTCGGAAGGCCACGAACGCTGGCAATAGCCACAGCAGCGGCCAATTTCTGGTTTCGAAACAGGAATAAGGCAAGTTGACTGCCCTCATTCTGTATTGACCGTAGCAAGGAGCGGTGTTACACTCCGACCAAGGGTGCCTGATTCTGCCCACAAGCAAACGCCAGGCGGGTTCCACATCATCTGTCTCTCGGGCATCCCCGACGGGTGACGGGTGGTCCGCCGCAGCCCAGGAGGTGAATGACATTGAAACTGCACGAACGACTTCGTGAATTGCGCAGCGAACGTGGGCTGCGGCTCAAGGACGTGGCCGAGGTTGCCGACATCAGCGTGCCGTACCTGAGCGACCTGGAGCGCGGGCGCACCAACCCCAGCCTCGAAACCCTCCAGACCCTCGCCGGGGCGTACAACATCACGGTTCACGACCTGCTCGAAGGGGTCGAGTTCTACGGTGAATCCACCGACGGCGCCCTGCCCAAGGGCCTCGCGGACCTGATCGCCGACCCCACGCTGGGCCCGCAGATCACGCCCGACTGGGTGCGGACCCTCTCGCGCATCGAGTTGCGTGGCAAGCGCCCGCGCGACAAGCAGGACTGGTACGAGATCTACCTGCATCTCAAACGCATCCTGAACTGATTTCCGCACAACTCCGGCCCCGTCGCCGGGGTTTTGTTCTTGGGAGATTCAAAAATGGCGCCCCCTCGCTGACCTTTCCGTCGAGGGGGCGCCGTTCTGTGAGGAGGCGTGTCAGGTCAGCGGTAAGACCTGCCGGTGCTCGGCTTCTCGCCGTTGCAGCACCAAGGTTCCCGCTCCCCAGGCGCCGCCGACGAGGGCGAGCGCGAAGGCCAGCGGACTCCAGCTCAAGCTGCCCGCAAAGAGGCTGATGCCCAGGAAAGCGCCGACCGTATCGGGCACTGGCAGGCGCAGGCGGCAGGCGAGGGCGCGGCCCAGGTCGTAGACGCTGACGCTCAGGCCAGTGGCGATCAGCAGCCCCGCCAGCGCAAGCACCAGCAGCGCCGGGCCGAGCAGACCCGCAAAGGCCAGCGCTAGTGCCGGCAACAGCAGCGCCGCGAGCAGCAGCACGCCGAGCGCCAGCGTCCGCATCGGCGCGTGCCGTTGCTGCCGGGCGAGATCTGGGGCTGTGCCTGCCACGAAGAGCAGCAGCAGCAGGCCCGCCGTGAGCGTCACGAAAATCTGCGGCCACGCGGCGGCGCCCAGCCAACCGAGCAGGGGCCGGAAGGCCGCCGCCGTTGCCAGCCGCACCCCCTGCGGCGCCGGCAACGCCCCGACCTCAGCGGCCTCGCCGGGGGTGCGGCCCAGCACCGCGCTCATTTCGCCGCTGACCTGGGCGCCGGGCGCCTGTTTGATGTCGCCCAGCAGAGTGACCACCCGGCCATTGACAGCGGCGTCGGGCGCCAGCACCACGTCTCCGCCGATGGCGACGATATTGCCCTCGACGGGTCCATGAACCTCCACCGGGTGGCCGAAGCTCAGGCCGGGTTCGCCGTTGACCAGGCTGGCGAGCGGCGGCAGCGACAGCGCGCCGGCCAGCACGAAGGCCCCGGCCCCGAAGCGCCGCACGGCGGGCGTGGGCATCCAGGTGACCAGCGCACTCGTGAGCAGCAGCAGCAACAGGCCCAGGCCAGCGACGGGTGCCACGTGCTCCAGCACCGTCTGCATGACCAGGGCGCCCGCCGCCAGGTTGGGCCACGCCGCCGTGACCGTCAGCAGGGTGAGTCCGGTCAGCAGCCCACCGACGAGCAGCAGCGGAGCGTGGCGGCTGTGGGAGGCAGAGACGGATCTGGAAGCTGGGACTTGGGCTGGTGGCGTCACTTCCAGTGAAGGTGGTGCGGAAACAACAGCCTCGGCCTGCTGCCCCTCCTGCGCGATGCGGCCCGCCAAAGATGCCGCCAGCGAGCGGGGCGGCGGGGGCACCGGCGCCTGCTGCAACACATTTCGCGTGCGGGCGTCGCTGGCAATCTCGGCAGCTAAAGATGCGGCGACAGGACGTAGCATTGGAGGCGGCGTCTGCAACAGCGCGGCGGCCCGCAGGTCGCTGAGGACGGCAGGTGCCACCGAAGCAACTGAAGGCAGAGGTGCGGCCCCCAGTTGCCGGGCCAGCGCGATGTCCTGCGAGACACTGGCCGCGAGTGAACGTGGGAGGGCTGGCGGAGCAAGAACACCGCGCAGGGTGGCACTGCTGGCAATTTCACTGCTCGTTTCGGCAGCCAATTGGTGAGCGAGTTCAGGTGCCAGCGTCGGCGCGGTGAGCTGTTTCCCCAGGCGAAGATCGGCCAGCACCGCGTCGGCCACACTGCGGGGAGCAGGCGGATTGGGGCCGGTCAGCAGCGAGATGGCCCGGTGCAGTGAGCGCCGCGCCTCCTGCACCTGCGGGTCAAGGCAGGCGGCGTCCAGGGCGGCCTGTTCGTCCGCGCTCAGGTCGACGTCCGCCTCACGGTGCAGCAGCGCCCGCAGCTCCGGTGTCAGAACCTGCGTCCATTCTGGTGTGTTCCACCCCCCCTCTTGCCGTGCGCCCATCGTCGGTCCCTCCTCGTCCCTTCCTTTACGTCAAATCCGCCTGCAAAGTTCCCGGCGGTGGGAGAACGGTCGCCGGAAATTATCTAGACAAATTAGGGATTAAGGCTGGGGCGGACGCTCGGCGGCCTGGTAGTCGCCGCTTTTGCCGCCGGTCTTGGACAGCAGCCGCACGCCGCTGACCTCGATGGCCTTGCTCGTCGCCTTGAGCATGTCGTAGACGTTGAGCGCGGCCACCGTGACGGCGGTGAGCGCTTCCATCTCGACGCCAGTGGGGGCAGTGGTTTTGACGAGGGCGGTGATGTGGATGCCCGCGTCTTTCAGCGTCACGTCCACCTCGGCACTCGTGACCGGAATCGGGTGGCACAGAAAAATCAGGTCGGCGGTGCGCTTGCTGCCTGCGAGCCCGGCGAGGCGCGCCACGCTCAGGGGGTCGCCTTTGGGCGTTTGCCCGGCGAGCAGCGCGGCCCGCGACTCGGGCGGGAGCAGCACCCACGCTTCGGCGCGGGCGGTGCGGGTGGTGGGCGCCTTGGCCGACACGTCTACCATGCGCGGCTGGCCGCCGACGAAATGGGTGAGCTGCGGGGCGTCGCCTTGCGGGTCGCTCATTCGTCGGGCAGCTCCAGGTCTTTCAGGCGCGCGAAGGGGTTTTGCTTGGCGTGGCTGCTCCCCTCGGGCGAACCGAGTTCGACGACCTGCTCCTCGATGGGCACCTGGGCGCTGTGTTCGCAGGGGCCTTCGTTGAGGTCGTGGCCGCAGACCTGACACAGGCCCTTGCACGCGGGGTCGTGCAGCACGCTCAGCGGCGCGGCGAGCAGGGTGCTTTCGGCCAGGTACGCGCTGAGGTCAAGGTCGGGATTGCCGAAGACGAGGACTTCCTCGCCAGTTTCGGCTTCTTCGATGTAAGGCTCCTCGGCGGAGGGTTCGTAGCGCATCAGCGTGCCGAGGTCGATGTCGAGCGGCACCTGCACCTCGCGCAGGCAGCGGGCACATTCCATGACCAGCGTGGGCGAAAACTGGCCTTGCAGGTACATCTCGTCGCCGCCAAGCGAGTTGATGTCCACCTCAAAAGCGGCAGGCTCGGCAAAACGCAGGGTTTGCGGCTGCTTGCCCTGAAGGTACTGGAGGTGGTCGAGTTCGCCCTCGGCGTGCGCGTCGTCGGCGGTTCGCAGCAGGGCTCCCAGGTGAATGCGGGGTTGATCGTTCATGGGCGCCATGATAGAGGGCTGGCCTGCGGGCAACTGCGGCGGCGTGGGGGTTGCGCCCTGGTGAGCGATACGGGGGAAGGGCACCGCTGCCGGTGTTCCGTTCAGGGTTCATCTGTCCTGCCCGGCGCGGCGGCATACTGCGGGGCAGTGCTCGCCCCCTCCCGTGACCAGGCCCCTGTGACTGACTTCCTTTCCTCTACCCCCCTGACCGCCTTCCGGCGTGCGCTGGCCCGTGTGCTCGCGCTGCTGGTGGGTTTCGGTCCGCTGGCGGCGCACGCTCAGGCGGCGGGCACAGCGGCGGTGAAGCCCCTGGTCGCCACGGTCGCTACGCCGTCGGCCTCGCGCCCAAACGCGGCGCTGCGCTGGACGCGGCTGGGGAACCCCAGGTCGCCCTCGCTGCTGCAAGTGCCCGCCGATTGCCAGGTGCGCAGTTGCCCGCTGGTGGTGGTGTCGCACCCCCGCGCCCAGGACGCCGCCCGACTGCGCGACAGTGCCCAGGTCGGCAAAATCTCGCAGGCGCTGCTGGCCGCCGATTTCGCGGTGCTGCTCAGCGGCGACGGCGGCGTAAACACCTGGGGCAGTCCGGCAGCGCTGCGGGAAGTCGCGCAGGTTCACCGTGAGGCCACCAGCCGATTTCGCTGGAACAGCCGGACCTACGCCCTGGGCCTGAGCATGGGCGGGCTCCTCTCGCTGCGCAGCGCCCTGCCCGATTCGCCCTATACCGTCCGGGGCGTAGCTCTTATTGACGCCTGGGTCAGCCTGCGTGGCGCGTGGGGCAGCGCCCTGTCGCGCCAGCGTGAAATCGGCAAGGCGTATGGCCTGACCGTGCCGCCCACCCCCACCCTCGACCCCCTGCCCCTCGCGCAGCGCCTGGCTCCGGTGGCGCCGCTGCCGCTGTTTCTGGCCTACAGCCCCACCGACACGGTGGTGTCCTCGCGCAAGAATGCCGAACTGCTGATTCCCAAGGCCGAACAGGGCGTGAGCGAGATCGTGCGCCTCGACGGGCCCCACCTCGGCGGCAACCGCTTCTCACCGCAGATGATTGCCCGGCTGGTCGGCTTTTATCAGGGCCTGGAGCAGCGCGCCATTGCCCGCCAGCACAAGGAATTTCCGCCTGGTCTCCCGGCTCCGGCGGTGCAGCGGGCTCAGACGGAGACGTCGAAAAGCTAAAGGCGAGGGGGCAGAGAAACCGACTTCTCTGTCCCCTCGCTTTTAATGGGTTTATACGGATTTCGTCCAATTCCCCCACCTCCGGAACGGCACCGGAGGCGGGACCATTTCCCGAAATCCTTTTTACTGCTTCTCACTCCGTTCGGATGGAATCCCCAGAACCGGGGGATCCCATCGCAGCCGGTTTACATCGCCGCCGGAATCTCGATGCCGATGAGGTCCAGGGTGTCCTCGAAGGCTTTGCGCAGCCGCACGATCAGCGCCAGCCGCGCTTCCCGCAACCCTTCTTCCGATTGCAGGACGTTGGTGGCGGGTTTGCCCTGCTTGGTTTTGGCGTTGTACCACGCGTTGAAGGATGTGGCGAGATCGAGCGCGTACTGCGCCACCACGTGCGGCGAGTGGATGCGGGCGGCCTGCGCGGCGACTTCGGGCAGCTTGGCGATCTGCTTGGCGAGCACGAGGTCGATGTCGGGCAGCGCGTCCCAGTCGGCCCCGGTGCCGTCGGTGGCATAACCGGCTTCCTCGGCCTTTTTCAGGATGTTGGCGGCGCGCACGGCGGCGTACTGCACGTAGGGCGCGGTGTCCCCGTTCAGCGCCAGCGCCTGCTCCCAGCGGAAGTCGATTTTGCGGGTCGGCTCGGCCTTGAGCATGGCGAAGCGGATGGCGCCCAGGCCGATGCGCCGGGCGATTTCGGCGGCGTCCTCGCGCGCGGCCAGGTCGGGATTGATGCCCTGCAAGACGCTCAGCGCGCGCTTCTGGGCCTCGTCCATCGCGTCGTCGGCACTGACCGCGATGCCCTTGCGCCCGCTGATGGTCTGGCCTTCCAGCGTCACGAAGGCGTAGGAGAGGTGGATGCTGCGCTCCTCCTTCTCCTGCTCGCCCGCCACACCCAGCGCCGAACGCACCACCGTCTGCGGGTGGTCCTGGCGCGAGTCGATCACGTTGATGACCTCCTGCGCGTGCCCGAAGCGCCGCTCATCGTCGGGCTGGCCGTCCGGGGCACTCGTCCAGATGGTGTTGCCTTCGGGGTCCTGCATGAAGGGCTTGAATTTCATCCCCTCGAACAGGCCGAATTTCCAGAACTGGTAGCCGATGTCCTTGGCGGCGTACATGGCGGTGCCGCCCGAGCGCACGAGGACCACGTTCGGTTCTTCCAGCCCCGGCATAAATTCCGACACGTCCATGATGAACGCCCCGGCGTACTTGCCCTCGGTGGGGCGCGAGGTGTACCTGCTGCCTTCCAGAATGTTCATGGCCTGCGCCAGAAACCCGCTGCCCACCACGTCGGATTCCCAGTTCAGCAGGTCGTAGCGCGCGCCGAGGCGAAAGCAGGTCTGAAGCTGCGCCTTCACCGTCTGCTCGACCAGGGGCCGCAGCTCCCCGGCTTCGAGCTTGTGCATGATCTCCATGATGCCGCTTTCCAGCTCGGGCTTCTGGGGGTCGGCGTTGAGCTGCACGTAGCCTTCACCGAGCCACTGGTCGTACTTCTGCACGCCGTCCCAGACGCGGCCGTAATGCTGGGTGGCGAACAGCGACTCGGCGGCCTGTCGCCCGGTGTCGTCGATGTAGTTCTGTACCTCGACGGTGTGCCCCGCCGCCCGCAGAATCCGCGCCATGGAGTCGCCCAGCACCACGTTACGCAGGTGCCCGACGTGCAGCTCTTTGTTGGGGTTGACCGAGGTGTGCTCGATGACGACCTTGCCCTCGCGCTTGGGCAGCTCGAAGGGACGCTCGACCACGCCGCGCACGAAAGCGCCCGCGTCGAGGAAAAAGTTCAGGAACGGCCCCGTGGCCTCCACCCTGCGGATGCCGGCGGGCAGCACCACCGTCTGCGCGAGCTGCGCGGCGATCTGGGCGGGGTTGCCCCCGGCCGCCTTCGCCATCTGGAAGGCGGCGGGCGTGCCGTAGTCGCCGGGTTTATTGGCGGGCGTTTCCTGAATGGCGGCGTCGACGGGCATTCCCATCTGGTGCGCGGCCTGCTCGACGGCTGCTTTGAGTTGGGCCTTCAAATCCATTCGGGCAGTTTACGGGGCGCGGGCGCTGACAGGGTCACGGGGCAGGAAAAGAGGCCATGCGCCACTTCCCGCCCCTGTGCTGAAGGCCAAAACTGTCCGGAATCGGGTATTATACGGCTTTAATCCGATTCCCGAACATCCGGAAAGGCGCCGGATGTCCGTCTATCTCCTTAAAACCGTATTTTTCCATGCGCTCCGCGCAAAATTGCGCCTGGACATGTCCGGGACTCAATTTGAAACCGTATTACCGCTGTTTCAGCGCCGCGTCCCGGTAAAAGCGCTCCAGCCCCAGCGCAATGGCCTGCGCCAGTCGCTCGCGGCCCGTGTCGCTCATCAGGGTGCGGAGGTTGCTCTTGTCGGTCAGGAAGGCCGTCTCGATCAGGATGGAAAGCTGCGTGGTGGGCCGGGTCAGCGCGAGGTTCTGGTAATGCACGCCGTCGTTGCCCACGTCGGGCAGTTTTTCCACCAGGGCACCCTGCACCGCGTCGGCCAGGGCGCGGGCCTGTGGATTGTAAAAGTACACGCCGCTGCCGCGCTTGGTCCGGGGGTCCACGCCGTCAGGCAGCGCGTTGGCGTGGATGCTGACGAGCAGCTCGGCGTTCTTCGCCTCGGCGAGCAGTGGGCGGTTGTAGATAGGCACGGTGGTGTCGGCCTCACGGGTCAGAATCACGTTGGCGCCCTTCTCGCGCAGCAACTCGGCAAGGCGTAGCGTCAGCGGCAGCGTGAGGTTCTTCTCCGGCACCCGCAGCGGTCCCGCTCCGCCGAACTCGTCGCCGCCGTGACCGGGGTCGAGGACGATGGTGCGTCCGGCAAGCGGCTGGCGGGCGTTGATGGCCGGAGCATTCCGCACCCGCAGGGTCAGGGTGTTGCGCTCGGCGGAGTCGTCGGCGCCGTAGGTCGCGTCGTAGCCCCAGGGCGCCCCGTTCAGGTCCACGTGCAGGCGGACCACGCCGTCGGCGTCCTGCACCCAGCGCACGTCGCGCACCGCGCCCGTCGGGACGTCGGAGACGATGTACTCCACGTCGGACACCGCGTGGAACAGCCGCAGGTCGAGGCTGCCGCCCTGTCCGGCCTGCTGCTCGACGGTAAAGGGCACGCGCTCGGGGAGCAGCACCTGCACTTCGCTGTGGGTGCCGCTGTTTTTCACATTGATGTTGGCGAACACGGCGCGGGGAAGGGGCGTGCCTTCCGGGCGCAGCGTCAGGGAGCTCTTCGGCGCGTTGAGCGTCAGGCCATCCGACACCTGCACGGTGTAGGTGCCCCCTTCCTCGCCCACCACGATGGTCCGGGCGCCGGGGCGGGGGTAGACCACGAAGTTGCGGCCCGCGCCGTTGCGCCACACCTGCCCGGCGGCTTGCAGGCCGCGCCCAGCGACGGTGGCGGTGACCTCGGCCACGCGGGGGCCGGTGCCAGTCACGCTGAGTTTGCCGGTGCTCTCGGCGGTGGCCGTGGTGCCGTCCGCGCCGGTCAGCGTGAAGGACACGGGCGCAGCGGCGAGTTGGGCGGGCAGCAGGAAGGTGCCCTCGTACTCGCCGGGCGACGTTTCAGCCAGGGGAAAGGGGCCGAGGTCGCCGACCTTGTAGCTCGCCTTCCCACCGGGCGTGCCGCTGAAGCCGACCGGCACGCCGCGCGTTTCCAGGTTCGCCGGTTGCAGGTAGGCCACCCGGTTCTCGTCGGGCAGCACGCTGTCGGCCACGATTTGTGCCGCGCCCCTCAGGACTGTCTGCGGGCGGCTGGTCACGCGCAGTTCTTTGGTGCTGGTCACGCCGCCGAGGGTGGTTTCGAGCTTCAGCACATTCTCGCCGGGGGTCAGCGGCACCCACTCGATAAACAGGCCGTCGGCGCCCACGTCCACCGGCTGTCCGCCGAGGCTGAAGGTCGCGCCGGGCTTGACGCTGCCTTCGAGCAGCACGTGGTCGAAACCCACGCTGTACTTGTCGGGCGGGTACGCCACAAAAATCGGCTCGTCGCTGATAGGCGGCAGCAGTCGGGTCGCGCTGGCGGGCGCCGGCGTAGGCGAGGGAGCTGCGGGCGCGGCGGTTTGCGCGGCAGCGAACGAGGCGAGCAGCAGGGCGGGGAGCAGGGTACGTTTCAAGATAAAGACCTCCCTCGAATTGTGGTTCGGGGCGCAGTGTACGTCAGTTGCCCGACTTGAGGCCAGCGCGTCTGAGTTCGTTTCTGAGTTCCGCCACCGAGTAGCGGCGCGAAGGCAGCCGCAGCAGCGTGAGGCCCCCGGAGCGGAAAATCACGTCCTTGACCGAGTCGCGGTACTGCTGCTCGGCTTTCTGGTGCGACTTGCCGTCGAGCTCGATGGCCAGCCGGGGCCGGAAGTGGTCGGCGGCGTCCACGATGATGAAATCCACGTGCTTGTCGCGCAGCCGCCCCAGCACCGCGCCGCGCTGGGCGGGGTCGTCGATGGTAAAGAGGTCGTTGAGCCGCACATTGGGAAAGGCCCGGTAGCTCGTGCCGCGCAGCGCGTCTTCCAGAGCGCGAAAAAAAGCGTTCTCGTCGGCGGAAAAGAAGTAGCGCCGCGCCGAGACGGGCAGCGAAGTCGGCACCCGTTTTTCGCCGGCCAGAGGAGATGGAGGTGAGGAAGAAGCCGGCGCGGGCGCGGCGTCCCGCAGGCCGAACAGTGAGGCGAGGCATCCCAGGGGCATGGGAGCAGTGTAGGCAGGCATGGAATCGCGGTGGATTTGGGCCTCTGCATGAGACGCGGGTCAGCGGCGGCTGGCCTATGCTATAGGGAGCCGCCAACTCGGTATACTCTCCCGAGTCTTTGTACTGAGTTCAATATTCCGCCTGCCCCGCTGCGCCGCGCCCCTGCGCTTCCCCCGGAGGTTCCCGAGTTGCTCCCCCTTGCCCATCAAATCGCCTTTTTCATCTTCGCTCTGGTGACCGGCGCTGTCGGCGCTTACGGCTTTTACCGGCTGTTTTTGCGGATTCGCCGGGGCGTCCCTGCCAGCGAGTGGCGCTGGAACGACGCCCCGCAGCGCATCGGCTACGCGCTGGTCACCTCGCTGACCCAGGAACGCACCTTCCGCAAGCGGCCCTGGATTAGCGTCCTGCACGCCTTTATCTTCTACGGCTTTACCTACTACTTGCTCGTCAACGTCGTGGACGGGCTGGAAGGCTACCTTCCCTTCTTGCACATCAGCAGTGCCACTCCGCTAGGCGCGCTCTACAACGTCCTGGCCGACATCCTGAGCCTCGGCGTGCTGATCGGCGTGATCGGGCTGGTCATTCGCCGCCTGTGGGGCAAGAGCCGGCGCGACTTCCGCTTTACCGACAAGACGCTGCTGCATCCCCTCGTCAAAGACAACTACATCAAGCGCGACTCGCTGATCGTCTCGGCCTTCATCACCTTCCACGTCGGGAGCCGCATTATCGGCAACGCCGCCAAGATGGTGCAGGAAGCCCGGCTGGACGCGGGGCACTACGACGCCTTCCAGCCGTTCTCCTCGGCGGTGGGCAGCGCGCTGTTCGGCGGCCTGAGCGACTCGGCCTTGCAGGGCTGGCGCCTCTTCGGCTTCTGGGGGGCGCTGGGCAGCATTCTGCTGTTCCTGAGCTACTTCCCCTTCTCCAAGCACATCCACATCTTCATGGCGCCGGTCAACTACGCGCTCAAGCGCCCCGTCAACAGCGGCACCCTGCCCCCCATGAAGGGCCTGGAAGAAGCGATGGAGGCCGAGGAACCCAAGCTGGGCGTGGAAAAACTGGAAGACCTGGAATGGCCCCGGTTGCTCGACGCCTACGCCTGTATTCAGTGCAACCGCTGTCAGGACGTGTGCCCGGCGAACGCCACCGGCAAGGCCCTCTCGCCCGCCGCGCTGGAAATCAACAAGCGCATGGAACTGAACGTGATCGCGGCGCAGCACAACCCCTTCGTGCTCAGGCCCGTGCCGTTCGAAGCCGGCGAAAGCACCGCCCGTCCGCTGCTGGAATACGCCATCAACGAGGAATCGGTGTGGGCCTGCACCACCTGCGGCGCCTGCATGCAGGTGTGCCCGGTGCAGGACGAGCAGATGCTCGACATCGTGGACATCCGCCGCAACCTGGTGATGGTGCAGGGCGAGTTCCCGCCGCAGCTCCAGACCGCCTTCCGCGGCATGGAACGCGCCAGCAACCCCTGGGGCATCTCGCGCGACAAGCGTATGGAGTGGGCCGAGGGCCTGAAAGTCCCCACTATCGACGAAAACCCCGAACCCGACGTGATCTACTGGGTGGGCTGCGCCGCGAGCTACGACCCCGGCGCTCAGAAGGTGGCCCGCTCCTTCGTGCAACTGCTCGACAAGGCGGGCGTGAACTACGCCGTGCTGGGCAAGAAGGAAGCCTGCACCGGGGACAGCGCCCGGCGCGCCGGGAACGAATTCTTGTACCAGCAACTCGCGCAGGAAAACGTGGAAACGCTCAATCAGGTGGCGCCCAAGCTGATCGTGGCGACCTGCCCGCACTGCATGAACGCCATCGGCAACGAGTACCGGCAGATCGGCGGCGACTACCGCACCATTCACCACACCGAATACCTCGAGCAACTCGTGGCGGCGGGCAAGCTGCCGACCGCGCAGCTGCACGACAACGTGGTCTACCACGACCCCTGCTACCTGGGCCGCCACAACGGCGTGTATGAGGCGCCCCGCCAGCTGATTTCGCAGATGGCTGGGCAAATTCTGGACATCGAACGCCAGCGCGAGAACTCGTTCTGCTGCGGTGCGGGCGGCGCTCAGTTTTGGAAGGAAGAGGAAGAAGGCCGCGAGCGCGTCTCCGACAACCGCTTCCGCGAATTGCAGGCGCGGCTCGACACCGCCGCCGAGGCGAGCGCCGAATTTGAACGCACCGGCAAGGTGCTGGCGGTGGGCTGCCCCTTCTGCAAATCCATGATGAACTCCACGCCCGAGAAGCAAAAGCGCGACGACATCATCGTGAAAGACGTGGCCGAGCTGATGCTCGAAAGCGTGCAGCGCGCCAGTGGCGAGTGGGTCGAACCTGCCGTGGCGCCCTCGCCCGAAGTCGAAGTGCCCAACGCGGCGCTGCCGATGGAACGCACCGGCGACGCCCCCTCCGCCGACGCCCCGCGCGACGACGTGGTGGGCACCACCAGCGCCGACGTGGAAAACGCCCAGCCCGGCAGCCCGGTGGCGAACGCCGGCACCCAGCCCGAGGCTCAGGCGGCGGCCCCCAGCCCTGCACCCAGCGGCGAAGGCACGCCTGTTCCGGCGGCCCGCAAGTCGTGGAAGCCCAAGGGCGGCGACGACGTGAGCGCGGCGGCTCCGGCGCCCGCCCCTGCCGCCTCCACTGCCGAGGGGGCCGCTCCCGCCCGCAAGAGCTGGAAGCCCAAGGCGAGCGCGGATGATGTGGCCTCCACCGCGACGGTTATCGAAGCCGCACCCGCAGCTCCGGCCCCCGAAGCTACCGGCACCCGCAAGGCCTGGAACCCCAAAGCGAAGGCCGACGACGTGGGCACCGCGCCCGCCGCGCAGCCTGCCGTTCCTGCTCATGCCCCTGCCGCTGAAGGTGCCGCCCCCGCCCGCAAAGCCTGGAATCCGAAGGCGAAGCCCGAGGACGCTGCCCCTGTGGCGCCCGCCCCCATGCGCGACGACGTGAACCCGGCGCCGGCAGCTCAGGCCACGGCATCTGCCGCCCCCGCCGAAACGGGCGCCACGGGACGCAAGGCCTGGAACCCCAAGGCGAAAACTCCGGCAGCGGCGGAAGGGTCGGCCCCGGTTCAGGAAGCGGTGCAGGAAGTTGCTCCTCAGCCTGCCGTCGCTCCTGCCCCCGTGCAAGGCGATATTCAGGATCCGCTGCCCCAGCCTCCGGTCCAGCAGGCCAGTGCCCCCGCCCAGAGCGGTGAGCGCAAGAAGTGGAACCCCAAGGCGAAAGCCGAAGCGGCGCCCGCTCCTGCTGCCCCCGCCGCGCCCATCACCGAACACGTCGTGCTCGACGAAGTCGGCGTCAACGGGCTGGAAGAAGGCCCCGAGGCGACCTCCGCCCCCGACGCGGCCCCGGTCACGACCCAGCCCGCCACCCCCGAGCCCTCTGCCTCCCAGACCGGCGAAGTCAACGCCGAGACGGGCCGCAAGAAGTGGCAGCCCAAGAACAAGGGCTGACACCCACTCCTGAGTCGAGTCCACTGAGTGAAGTACGCCCCCGCCGGGAAACTGGCGGGGGTTTTGCTTTGCCTGCCCTCTACAATCCGGGCGTGAACCTCCTGCTCATTCGGCACGCGCAGTCCACCAACAACCTGCTCTACGCCCAGACCGGAGGCAGCGAGGGCCGCTCCGCCGACCCGCCCCTGACCGAACTCGGCCACGCGCAGGCACGGGCGCTCGCCGAGTTCGCCCGCACCGACGAGACCCTGCGCGGCCTGACCCACCTGTATTGCAGCCTGACCACCCGCGCGGTGCAGACGGCGGCGCCACTCGCGGCGGTGCTGGGGCTCGGCGTGCAGGGCCTCACGCACGCTCACGAGACCCAGGGCCTCTTCCTGCGCGACGAGGCCGGGGTGCCCCGGCCGGTGCCGGGCCGCACCCACGCCGAGCTGCTGACTGAGAATCCCGCGCTGCTCTGGCCCGCCGACCTCGCAGCGGAGGCGGCCTGGGAAGGCGGTTTCGAGCCCGAGGACCACGCGGCTTATCTGGCCCGCGCGGCCCGCGTGGTGGGTGAACTGCGCGCGGCGCACGGCCCTCAGGACACGGTGGGGCTCGTCACCCACGGCCACTTCACCCAGTTTCTGCTGCGCGAGCTCATCAGCCACGGCACGGCGTTTTTCCGCGTCGCCAACACCTCGACCACCCTGCTCACCCTGCCCGGCCCGCAGGACCCGCCCGAGTTCGGCCCGCTGGTGGGCTGGGTCAACCGGCACGACCACCTGACGCCGGAGCAGGTCACCGTTTGACCGGAGCTGTAGTTTTGCTTACAGAGACGCACTTTTGCGGCCCTTCCCGTTAGAAATACTAAGGACGGCTGCCATCCGGTCAGGGTTTCTGCGGGTCATGCTGAGGCACTGCCACTTCGGAACCCGAGGTGGACAAAGGAGCACCCCATGAAACTGAAGATGTCCGACCTGATGATTCTGCTGGGCTACGCCTCCATCGGCTATAGCGCCTACCGTTACTTCACTGCCAGCGACGACGACTCCAAGCGCGACGCCCTGTTCGTCGGTCAGTGGGCGCCCACCTTCTTCATCCTGGGTGTGGGGGCCGAAAACCGTGAGTACCGCAAGCAGAATACCCTGGCCCTCGACGCCAACGCCTGAGCCCCGAACCTCTCCGCAGAGGCCGTCCATCCGGGCGGCTTTTTGCTTTTGCGGCCCTCCGCCCCTTTTCGATGTCAAGGTGACTTATGAACCTGACTCCCGCTCAACGCAGCAATTTCTTTCCCCTGACCGCCTGGGGGTATCCCCTGTGGCGCGCCCGTTCGCTGACGTGGCTGGCCGGAGAACCGTTCGGGCTGGCGCGGGAAGCGCGGCTGTTTCTCGGGCTGTGCCGCCCTCATGCTGGGGAACGCTGGCTGGACGTGGGCACCAGCACCGGGTTTTACGCCGGGGTGCTGGCGCGGGCGGGCTGCCGGGTGGTGGCCGCTGACCTCAGCCCCGCCATGCTGCACGCGGCGGCGCGGCGGGAACCCCGGCCCCAGATCGAGTGGGTGCAGACGAACGTGGAAGAGACCGGCTGGCGCACGGCGAGCTTCGACGGCGTGGTCGTTGGGGCGACGTTGAACGAAACCGCCGACCCCGCGCGGCTGCTCGGCGAGTGCGCGCGGCTGCTGCGTCCCGGTGGCAAGCTGTGGCTGATGTTCGTGCCGCGCACGGGCGGGCCGCTGCAAGGGCTCCTCGCCCGGCTCGGTGGGCTGACCTTTCCTGACCTGAGCGCGGTGGAGACTGCCTTGCCCGGCGGCGCCATCGTTCACGCCCGGCGGGCGGGGGCCGTGCAGTTCGCTCTGTTCGTCCGGGGCAACGGGTAGGCTGGCAACATGCCGCCCCTCCGCTCCCAGATTCGGCCCGGCCTGACCGTGGACATCGTGCAAAAGCAGGACCAGCCCACCGGCAAGCTGACCCGTGGCGTGGTCGCGGCGCTGCTCACGCGCTCGCCCTCGCACCCGCACGGCATCAAGGTCCGGCTGACGAGCGGGCAGGTGGGCCGGGTGCAGGCGGTGGTCGGCGGGGAATAAAGAAAGTCCGACTTTCTGGCGCGGGGCCGCGAGGCTTACGTTAACGCCGGAGGTGCGCCATGCCCAAAGCCTGGAGCAACAAAGACGAACGTCAGTACGAGCACGTCAAGGACAGTGAGGTCAAGCGCGGCGAGTCGCCAGACCGCGCCGAGGAAATCGCCGCCCGCACCGTCAACAAATCCCGCCGCGAAGAGGGCCGCACCCCGAACAAGCGCACCCAGGGCACCGGCAACCCGGACGCCGCGCTGAGCGACCTGACCCGCGACGAGCTCTACAACCGCGCCAAGGAAAAAGGCATCGCGGGCCGCAGCCGCATGAGCAAGGCGGAACTGGTCAGGGCGCTGAGCTGACCCCCGCTGCACCATAAAAAAGCCCCTCCCAGCCGGAGGGGTTTTCTATTTGGCCGGTGGCTCAGCGCTTGGGCATGCTCAGGCCGAGGCCGGTGAGAAAGCCGCCCGCGACGGCGAGCGCGGTCATGAGCATGACGTTGTTGACGGGGTTGGGGCCCTCGTTGCTCTTGTTGGCGTAGGCGATGGCGTGCAGCTGGTTGATGTCGATGTAGTTCTTCGCGAGATAGAACAGGCTGGCCACGATGACCACCAGGCCGATCAGCACCACCACCTTGGAGAGAATCTGCATGGTTCAAATTGTAAGTCTCCGCCCGTTTGTGCCTCTTGGCCGTTCGGAAAGATTGTGGCGGGGCAGGGTCATCAGGGTCAGTGGGTCAGCGTCCGTGCGGCGTCGCGTCCAGCCAGGCGGTCAGCGCCTGAGCCACGCCCGCCGGGTCGGTGACGACCACCGGCACGCCGAGCGAGGCTGCCGCGCTCGCTGCCGCGCACTCGCCCTGTTCCCCCATTACGGTCCCGGCGCCGGTCCAGGCGGGAAACGGGCCGCCTTCCTGGTAGGGCGCGCCGCTGAGGTCGTCCACCACCCGCGCGGGCACCTCCACCGCTGGGCCACCTGCGAGGGCCCGCTCGGCCACCACCAGCACGCCCCGGTGTTCGCCTTCTTCCAGCGCGCCGAGCAGCGGGGTCAGTCCGTCGTGGACGAGCAGCTCGAAGGTGCCCTTGCCGTCCACTGCCGCGAGGGCGGCGGGCAGCGCAGCGGCGAGTTCGGGCGGCGCGGCGACCAGCCAGCGGTGGCCCCCGGCGCGGCCCTCGAAGCTGGCGCGGGGCGAGCCGTACACGTCCGTCCAGGTGCGGGTGTGTTGCATGGCGTCATCATCGGGCATGGGGGCCAGAGGGGCAAGCGGAGTCGCCCCGCTATGCTGCGCTCATGACGCTGCCTGCTCCCCGCACCCACGGTTCCGTTCGTCTGTGGTCGCTCCCCACCGGCCCCCTTCAGGAAAACGCGCTGCTCGTGGCGGGCTCGGACAACCAGGGCTTCTTGATTGACCCCGGCGACGAAGCGGCGCGCATTCTGGACCTCGTGCGCGCGGCGGGGGTGGACGTGCAGGCGATTTTGCTCACCCACGCGCACTTCGACCACATCGGCGCGGTGCAGCCGGTGCGCGAGGCGCTCGGCGTGCCGGTTCACCTCCACGCGGACGACCTCGCCACCTATCACCTCGGCGCGGCGTCGGCGGGGCGCTGGAACCTGCCCTTCGTGCAGCCCGCCGACCCCGACCAGCAGATTGCCCAGGACCAGACCTTCACGGCAGGCGACCTCACCCTGACCGCCCGTGAGCTGCCGGGGCACGCGCCGGGGCATGTGGTGTTCGTGGGCGACGGCTTCGTGATTGCGGGCGACACCCTCTTTGCCGGGGGCATCGGGCGCACCGACCTGCCGGGCGGCAACCACCCGCAGCTCATCGCGGGCATCGAGCGCGAACTGCTGAGCCTGCCGGACGACACCTACGTCTACCCCGGCCACGGCGGCTTCACGACGATTGGACGGGAGAAGCGGAGCAATCCGTTCCTGTAGAGCCTTTGACAAAAAGATGGCACAGCTTTTTGGCGAGCGGAGCGAGTGCAAAACACGGAGCAGAACGGACTTGCAAAGCTGCGAAGCAGAGAATGGAGCGGGTGGCGGTGCTGTTCCGACGCACGCGTCATTCGGAGAACTGCTCTAAGGCAGGAAAAAAGGCGCCAAGGTGAGTTGACCTTGGCGCCGTTTCTTTTTTCTCTTCCCTCAGTCGAAATCCATCGCCCACCACGCCTCGCGCTGTTCGGCCATGCGGGCGCGGGGGTCGCCGAGGGTGTCGAGCGACGCTTGCAGGCCCTTCCAGTCCTGTTCGCTGAGGGGGTCGAGCGTGAGCGCGCGCTGGTGGTATTGCGCGGCCTCCTTGGGCTTGCCGGCCAGGCTCGCGGCGCGGGCGGCGAGGCCGAGCAGGTTCATCTGGGTCTGTTCGAGCCGCGAGCGCACGTCGTCCACCCAGGGGCTGTCGGCGCCGGGCAGGAACGTGCCGTACTGCCCGACGAGTTCCTTGAGCTCCTCGTAGCCCAGACTGCCCGCTTCGGCCTGTCCGGCGAGCAGTTCGTAGCGTTGCACGTCGTACTCGGGGTTCAGGCCAGCGGCGAGCGCGTACTTGCGGTTCTGGCTGGTCACGGCCTCGTTGTTCAGGCTCTTGCGCAGGCGGTGCAGCGTGGTGTGAAAGAGGCTGCTCGCCCGCGACTCGTCTTTTTCGGGCCACAGCGCCTCGGCGGCTTCCCAGCTGGTGACTTCCTTGTGTTCGAGCAGGTAGAAAAACAGTTCGAGCGCCTTGCGCGACACCCACGACACCTGCTGCCCCTGCCACAGCACCTGCGCGGTGCCGAGCCCCTTGGCCTGGGTGCCGCTTTCGGCCTGCGCGGTCAGGCCCACCCGGCGCAACCGGGCGTCCACAGCGGTGGTCAGGCCCTGCGGCGTAAAGGGCTTGGGCAGGTAGTCGTCGGCGCCGAGGTTCATGCCCCGGCGCACATCGGTCCGCTCGGCGTGGCTCGAGAGCAAGATGAACGGCATCGCCGAAAGGTTCTCGTGGTCGCGCACCTGTTCCAGAAATTCCAGGCCAGTCATGTACGGCATCACCACGTCGCTGATGATCAGGTCAGGGGTAAACACTTTGAGCAGGTCCAGCGCTTCCACCGGATGCGAACAGCTCCGCACCTCGTGCCCGGCGCGGCTGAGAATGACGCTGATGAGCTTGACAATGGCGGCGTCGTCGTCCACGACCAGAATGCGCGGCATATGAGAAGTCTAACAGTTCGTCTCCGCCGCCGGCCGCCCCCACCCTGACGAATAAGGGCCCCCCTTACAATCTCGTGAGAAGCGGCCTGAAGTCGGTTTGTGCGGGCGTGTGTCCTGTTGTCCTGTTTGCCCCGCTGCCGCTGTCTGCCCGCCCTCCAGATGCGCAGCGGTCAGGGCGCTATCCTTTTTCCCATGACGTATCAGGCGGTCATCGGGCTCGAAGTGCACCTGCAACTGAACACCCGGTCCAAAATCTTCAGCGCCTGCCCCGCCGACTACCACGGCGCGGGGCCGAACGAATTCACCGACCCCTTGACCCTGGGCCTGCCGGGCACGCTGCCCACCCTCAACCGCCGGGCGGTGGAACTCGCCATGATGTTCGGTCTGGGGCTGGGCTGCGACGTGTCGGGTTTTACGCAGTTTCACCGCAAGAACTACTTTTACCCCGACGCCCCCAAGAACTTTCAGCTCTCGCAGTACGATCGCCCGATTGCGCGTGACGGGTATCTGGACGTGCCGGGAGAGGGCGGCCCCGAGCGCATCCGCATCAAGCGGGCGCACCTTGAAGACGACGCGGGCAAGCTCGTGCACCCGACCTACGCGCCCTACTCGCTGCTCGACCTCAACCGGGCGGGCTCGGCGCTGATTGAAATGGTCACGGAAGCCGACATCACCGGCCCCGAGCAGGCCCGCGCCTTTCTGGAAAGCGTGCAGGCCATTGCGCAGTCGCTCGGCGTGTCCGACGCGACCCCGGAGGAAGGCAAGATGCGCTGCGACGTGAATATTTCCATTCACAAGCCCGGCGAGCCTTGGGGCACCAAGGTGGAAGTCAAGAACCTCAACTCCTTTCGCTCGGTGGCCCGCGCCATCGAGTACGAGGCCGCGCGGCAGGCGAAGGTGCTGGACGCGGGCGGCATCATCACCCAGGACACGCTCGGCTGGGACGAGGGCGGCCAGAAGACCTTCCTGATGCGGACCAAGGAAGGCGAGGCCGACTACCGCTACTTCCCCGAGCCCGACCTGCCGCCGCTCGACATCACCCCCGAGTGGATTGCCGAGGTGCGCGCCCGGATGCCCGAACTGCCCGCGCAAAAGCTGGAGCGTTACCGGGCAGCGGGCGTACGCGAGAGCGACGCGCAGACCCTGAGCCTGAGCGTCAGCCTTTCGAAGTTCTACGACGAGGCTCTCAAAAGCGGCTCCGACACCCAGAAACCGGATGCCCAGAAGCTCGCCAACTGGCTGCTCACCGACGTGGCCGGGGCACTCGCCGCGCAGGAAAAGGGAGTTGAGGACAGCGACCTCCAGCCCGCACACCTCGCTGCGCTGGTCGGCCTGATTGACGCCGGAACCATCAGTGGCAAGATTGCCAAAGACCTGCTGCCCGACGTGCTGGCGGGCCACGACCCCGCGCAGCTGGTGCAGGAGCGCGGGCTGAGCGTGGTGACTGACACCGGGGCGATTGACGCCGCCATTGACGCCGCGATGGAGGCCGACCCCGCGACTGTAGAGAAGGTGCGCGGTGGCAACGCCAAGGCGATGAACGCGCTGTTCGGCCCAGTCATGAAGGCGATGGGCGGCAAGGCCAAACCCGAAGTCGTCCGCGAGCGCCTGACCGCCAAGCTGGGCCTGTGACCGCGCCGGCAGGGGCTTCCGGCAACCGCTGGCGCCTCCCGGCTCTCACCGCGCAGTGGCTCTACGTGGCCGCCAGCTTGGGGCTGACCGCGTATACGCTGCTGCCGGGGCTGAATGAAGGCACGGTCGTCACCGGCCTGCGCTCGCTGCTCGCCGCGCTGGTGGGGGCGTGGTGGGCGGTCATTTTCGGGCGTTATCTGCTCGGCCAGGGCACGCCGGACACCGACGGCACGCTCAGGGCGCTGCGGATTTTCTTTCCCTGGCTCACGGCGCTGCGGCTGTCTTTGTGGCTCATCGGGCTGCTGGCGCTGAGCGGCAACGTGACGGCGGAGGTCAACCCGGTGGCGCTGACGGCGCTGCAAACCCTGTCGTTCGGGTACATCTTCGCCAAGAACGCGGTGTACGGCACGCTCGCCCGCTACGCGACCGACCCGGCGAACGCGCTGGGGCGCCGGCGCCTGGGCGAGTGGCTCAACGTGGCCGCGCCGCTCGCCCTTGCCATCGGGGTCATCAACACCGTGCCGCTGGGCGGCGTGAGCGAGGGCTTCCGGACGCAGGACGTGGTGATGTATGGCGTCCACGCCGCGCTGGACCTGCTCGCGCTGGGGCTGAGCCTGCTCGCACTGCGCGAGATGCAGACCCCGGTGCGGGAGCGGGAGGCCTGAGCTGGGCCGAGTGCGGCAGCCCCCTTACTCTCCTGGCCCCTTGCTATCCTGAGCCTTACGCATGACAGACGCCTCTTTTCCGGCCTTGCCGCCGCCGCTGGTGTCCCTGGGTGACCTCGCCTGGGACGTACTGGCCAAACCCGACACCCTGCTGCTGCCGGGCGGCGACACCACCGGGCGCCTGGAACTCTCCGGCGGGGGCAGCGCCGCCAACCTGGCCGTGTGGGCCGCGCGGCTCGGCGCCCCGACCACCTTCGTCGGCAAAATCGGCCAGGACCGCTTCGGCGAACTGGCGACCGCCGAACTGCGCGCCGAGGGGGTGCGCGCCGAGGTGCTGGCAAGCGCCGCGCACCCCACCGGCGTCATCCTCGCCCTGATTGACCGCCGGGGCCAGCGCGCCATGCTGACCGGGCAGGGCGCCGACTGGGAACTGCTGCCGGAGGAGCTGCCACGCGACGTGCTCTCCAGTGCCGGACACCTGCACCTGACCGCCTGGAGCCTGTTTCGTGACCCGCCCCGCGCCGCCGCGCTCGAAGCGGCCCGCATCGCCAAGGCGGGGGGCGCCACCCTCAGCTTGGACCCCGGCAGCTTTCAGATGATTCAGCAACTTGGGCGCGAAGCCTTCCTGAACATCGTGGACGCGCTGCCCTTCGACGTGATGTTTCCCAACGACGACGAGGCCCGCGCCATGAGCGGCGAGCGCGACAACGAAGCGGCGCTCACCTGGCTGCGGGCCCGCTACCCCCGCGCCCTGATTGCCCTGAAGATGGACGAGGACGGTGCCCTGATCGAAGGCCCGCAGACCGCCCGCGTGCAGGTGCCCGCCACCCGCGACCCGCTGGTGGACGCCACCGGGGCCGGGGACGCCTTCGGGGGCGCTTTCCTGTCGCAGTGGCTGCGGCACCACGACGCCGAGCGCGCCGCCCGCGTCGCCGTGCAGGTGGGCGGCTGGGTGGTCTCGCGCTTCGGGGCTCGCCCGCCCGCTGACCCTGACCTCACCCGGCGGCTGGCGAGCGTGGGCGCCGATCTGTTGACCCCTGACCCCGCAGCTGCCCCTGACCCTTCCCAAGACTCTCCTGAGGTAAACGCATGACGACCCTGAATTCCCGCCGTGGCCTGCCGCTCTGGGCCAAACTGCTGCTCGGCTTGATCGTGCTGGGCCTGCTGGCCGTGCTCGGCGCCTTTGCCTATTTCCGCAGCCTCTTCGGCCCGGCGGGCGGCGCCCCCTACACGCTGGAAGTCACGCCCGGCGAGACCGTGCCGCAAATCGCCCGCGAACTCGAAAACAAGAAGATCGTCAAAAACGCCCGCATCCTGCGCTACGCCATGCAGCAAAGCGGCGCGGCGGCGCGGCTCAAGGAAGGCGCCTACGACCTCAACGGTCAGATGACGGTGGATGAGGTCGTCAAGACGCTGGACGGCCCCGCCCGCGTTCCGGTGGTCAACGTGACCGTGCCCGAGGGCCGGCGCATCAAGGACCTGCCCGAGATTTTCCAGAAGGCGGGCTTCGACGCGGCGGCCATCACGGCGGCGCTCAACGACGCGTCGCTCAGCCGCTACGCCCGGGGCAAGCAGAAGAACCTCGAAGGCTTCGTGTTTCCCGCCACCTACGAGTTCCGCCCCAAGGACAGCGCCACTGACGTGGTGAAGAAGATGGTGGAGCGCATGGAAACCGAGTTCACGCCGGGCAACGTCGCCAAGGCGAAGGCGCTCGGCCTCGACGTGCGCGACTGGGTGACGCTGGCGAGCATGGTGCAGGCCGAGGCCGCCAACAACGAAGAGATGCCGGTCATTGCCGGGGTCTTCCTCAACCGCCTGCGCGACGGCATTCCGCTCGGCAGCGACCCCACCGTGGCCTATGGGCTGGGCAAGGACCTGCCGGAACTCGACCGCTCGGCGGGGGACTTCAAGGTGGATACGCCTTATTCCACCTACACCCGCCAGGGGTTGCCCGCTGGCCCCATCAACAACCCCGGCGAGGCCGCGCTCCTGAGCATCGTCAACCCGCAGCGCAAAATGGCGGATGGGCGCGACGCCCTGTACTTCCTGCACGCGGGCGGCAAAATCTACGTGAACCACACGTATGCGGAGCACCTGCGCGACAACGACCGCTACCGCTGAGCCGACAAAAGGGAGGGGGTGGAGTGCCCGGGACACCGTTCCCGCCGCGCTCCACCCCTTCGCTGCCCTTCTCTTTCAGCCCGTTACTTCTGCGCTTTGAGCCACGTCGTCAGGTCGTTGAGCGGCTGGGCGTCCATCCAGCCCAGAGTCGGCCTGCCGTCTTTGAGCGGCGAGAGCGAGTGCCCCAGGCCCGGATAGACGATGAGCTTCACGCGCTTGTTGCCCGCTTTTTCGGCGGCGGCCTGCGCCAATTTCGCGCCGGGGAGGATGGTCTGCGGATCGGCGGCGCCGTGCAGCATCAGCACCGGGCCGCCGTAGCCGGGCAGGTTCTGCGTGACCGAGCCGTAGGCATCGGCATCCTTGAAGTAGCGGGCGGCAGCGGGGCCGAAATCCGGCAGGTTGGGGTACGGGGCAAACGCCGCCTCCAGCCGGTCCTTGATGGGGCCGTCAATCCGGACGCGGCCCCCGGCGTCGGCCTTCATCTCGGGAAGAAAGGTCCACGTCTTGTCCTTTTGCACCACGCCGAAGGCGGACGCTTGATCGGCGAGGTCGAGCCCGAAGCGCTCGAAGCCGGCGGTCAGCTCGGCAATCGTCAGGAAGCCGTCGTGGTCGGCGTCCATCAGCTCGTGAACCTGCGCGAGGGGCCGGTCGACGAGCTGGAAATGCAGCGTTTCGCGGAAGGTGTAGCCCACCGTGCCGATGAGCACCAGCCCGCGCACCAGCTCCGGGTGCTCGCGGGCGATGCGGGCGGCGAGCATGGTGCCTTCCGAATGACCGAGCAAAAAGACCTCACCGGGGTTGACCTCGGGCAAAGTCCGCACGGTCTGGAGCACGCCCAGCGCGTCGGCGGAAAACTGCGAGACGGTGGCCTGTTCGGGGCGGGCCGCCGGGTCGATGCGGGGGCCAGCGCCCAGCACGCCGCGCTTGTTGTAGCGCACCACCGCGAAGCCCGCCTCGTTGAGCTGCCGGGCGAGTTGCAAAAAGACCTTGCTGCCGCCGGGCACGCCGCTCACCTGTTCGGGCAGCGTTTCGTTGAGGTCGTTGGGGCCGCTCCCGTGCAGCAGAATTACGGTGCGGAACTTCTGACCCGGCTTGGCCCCCGGCGGGAGGCTGAGTTCGCCGGTCAGCGCATAGCCGTCCGCGAGCTTGAAGGTCAGCGGGCGAGTGTTTTGCAGAACGATCTGCGCGGGTGGGGCCGGAGGTGGGGTGGTCATGCCCAGAGTGTCGGGCTAGGCTACTTGCCATGCCAGAGCAAAATGCAAGTAGCGTACTCGTCCAGTCCGAGGGCGCGGCGCTGGCGCTGCTGGGCGGCATCGTGAGCGGCGAACTGGGGCCTTTTCGCCAGGGGCCGCTGAGTCCCGCGCAGTGGGCCGCGCAGCGAGGGGAACCGCTCTACCGCACGCTGCGCCGGGTGCGCCGCTGGCAGGCGCTCGGCGTGCTGGACGTGCAGGACACCAAAAAAAGGGCGGGGCGGCCCGTGCGGCTCTATGGCCTGACCTCCCCCTCCTTCTACATTCCGCACGCCGTGTTGCCCGTTGACGAGGTGCTGGCGCGCATCGGTGAGCCGATGGAACGCCAACTGCGCGCCGACATCGCTCGGGCCTTTGCCGACCTGCCCGACATCGGCGGCACCCAGATCGTGATTCACGGCGAGACCTACGGCGCGTTTCTCGCTCACTCGCCCGGTCAGCCCTGGGGCGGCAAAGACGACCTGGTGCTGATTGACCGCTGGGCGAACCTGCGCCTGACCCACGCCGACGCCCTCGCCTTTCAACACGAACTCGACGAGCTGTTTGCCCGCTACGAGCACCGGTCGGGGCCACAAAGCTACTCGTTGCATCTGCGGCTGGTGGCCTCGGCGGGGGGGGGGGCGAGCCGTTAGAGAGGCACGAGCCGCGTGGAAGCAAACAAAATGCGCTGCGGCTATTCCAGAAATGCCAGTAGCTCTTGATTCACCCGCAGCGTTTCGTCACGCATGACCCAGTGGGTGGCGTGGGGAAACTTGACGGTTTTCAGGTTGGGCACCCACTTGCCGAGGTTGTCGGCGAGCTCGGGCACCAGAGCCGAATCCTTTTCGCCCCACAGCAGCAGGGTGGGGGCGTGAACCTGCCGGCCCTTGACGTTCCCGAAGCGGATCAGGGCGCGGTAATAGTTGATCATGGCGGTGGCCGCGCCGGGCTGTGTCCAGGCGGTTTCGTAGTGGTGCATGTCCTCGGCGCTGTAGCTGCCGGGCCGCGCTCCGCCCAGGCCCTTGCGTCCAAAGGGCACCAGCAGGCGCTCGGGCAGCCAGGGGAGCTGGAAAAAGCCCACGTACCACGAGCGCTTTCTCTGCTCGGGACGGCGCATTTCCCGTCCGAAGGCGCCGGGGTGCGGGGCGTTGAGAATCACCAGTTTGTCCACCACGGCGGGCCGCGAGATGGCGACCGCCCAGGCAATCACGCCGCCCCAGTCGTGCCCGACGATATGGGCGCGCTCGTGCCCGAGGTCGTGGATGAGCGCCGCCACGTCGGCCACCAGCGTATCGATGTGGTACGACTCCACGCCCTGCGGCTTTTCGCTGATGTTGTAGCCGCGTTGGTCGGGCACCACCACCCGGAACCCCGCGCGGGCGAGCGGCCCGATCTGGCGGTCCCAGCCGCGCCAGAACTCGGGAAAGCCGTGCAGCAAGATGACCGGGGGGCCCTGTTCGGGGCCGGCCTCCACGCAGTGCAGCCGCACCCCGTTCACGAGGCGTTCGGTGTGCCGAAGTTCGCTTGACATGGTCCCAGTATCCTCCCCGGCGTGCGCGGCGCCGTGACCGCTGCCGGTGCCATTGTCTTTAGTTCGGCCGCGCTAGAGCATTTGACATAAGAATGTTTCGCATTTTTGACCCTCTACCCTGGTAGGACTCGAAGAGCTGCACCAAGGGGTCTTTTTCTGTCAAATGCTCTAGAATGTCCGGCGCATTTCGCGTTCCCCCGGACCCTGACGGCCCGGCGCGCCGGACGCACGCTCTACCTTTTTTTCGCGCAGGTTCGCACAGCACAGGAGACTTCTGAAACATGGCCGGTCATAGCAAGTGGGCGCAGATCAAGCGCAAGAAGGGTGCCAACGACAAGAAACGCAGCGCGATGTATTCCAAGCACATCCGCGCCATTCAGGCCGCCGTCCGCTCGGGCGGCAGCGGTGACCCGGCGGGCAACCTCAGCCTGAAAAACGCGATTGCGGCGGCCAAGACCGACACGGTGCCCGCCGACAACATCGAAAACGCCATCAAGCGTGCGGTGGGCGCGGGCGAAGGCGCCGCCGAGTACAAGGAGCAGACCTACGAGGGCTACGGCCCCGGCGGCACCGCCATTTTCATCGAGACGCTGACCGACAACGTCAACCGCACCGTGGCCGACATCCGCGCCGTGTTCAACAAGCGCGGCGGCAGCATGGGCAACTCTGGCTCGGTGGCGTGGCAGTTCGAGAAAAAGGGCATCATCCTGCTTCGCGATGCCTCCGAGGCCGCGCAGGAAGTCGCCATCGAAAACGGCGCCGAGGACATTCAGGAATCCGACGAGGGCCTGGAAATCAGCACCGCGCCGAACGACCTCTACGCCGTGCAGGACGCCCTGAGCGCCGCCGGCTACGCCGTGGAAAGCGGCCAGATCACCATGCTGCCGACCAACACGGTGGCGGTGGCTGGCGACGACGCCCGCAAACTGCTGACGCTGGTGGAATACCTCGAAGAACTCGACGACGTGCAGAACGTGTACACCAACGCCGATCTGCCCGAGGACGAAGAGGACTGACCGAAACGAGAAAGAACAAAAAAGCGGAGGCGTAGGCTTCCGCTTTTTGCTTTGGGTGGGGATGCGTTTTCCTGAGCCGTCGCTTCAATCACACGCCAAGGCCAGCTCCGCTTGCCGGGCGAGCTGCGTCTCACGGGTCAGATACCAGCGGCTGAGGTCCGAGCCGAGTTCGCGGATGATCGCTTCGGCCTGCGGGAGCGCGGCGCGGCGGCTCTGCATATTGCGCTGCACGACGGCGGTCAGGTCGTCGAGGTTGTAGAGGTGCGCGCCGGGCACGCTGGCAATCTCGGGGTCAAGGATGCGCGGCACGCTGATGTCAATCAGGAACATGGCGCGGCCCGGACGCCCGGCGAGCGCCTCGCGCACGTTCTGGGCGGTGACCACGTAGTGCGGCGCGGCGCTCGATGCGATGACCACGTCGACTTCGGGGAGCGCGGCGGACAGTTCCTCGGCGGGGCAGGCGCGGCCCCCCAGTTTTTCGGCGAGGGCGCGGGCCCGCTCGGCGGTGCGGTTGACCACCAGCACGTCCTGCACGCCTGCCGCCCGCAGGTGGGTCAGAGTCAGCTCGGCGGTTTCGCCCGCCCCCAGAATCAGGGCGCGGCGCTGCGAGAGCTCACCGAGCGCGGCCTGCGCGAGTTCCACGGCGGCGCTCGACACGCTGACCACCTTGTCGCTCAGGCCGGTGTGCGAGCGCACCCGCTTGCCCGCCGCCAGTGCGCCCTGCACCACTTTGTTCATCAGGGTGCCGCTCAGACCGCGCTCGCGGGCACTTTGCCAGGCACGTTTGACCTGTCCCTGAATCTGGGTTTCGCCGATGACGAGGCTGTCGAGCCCCGCCGTCACGCGGTAGAGGTGCCGCACGGCGGCCTCGCCCCGGTACACGTAGAGGTGATCGAGCAGCGCGTGGCCCCAGGCGCCCTCGAAGGCGGCGAGCGGGTCGCCGTGCACCCCGGCGAGATAGACCTCGGTGCGGTTGCAGGTGGCGAGCAGCAGCACCTCGTCGGCGTGGCGCGCGAGGTGGCCGAGCAGCGCGCCTTCTTCCTCGGGCCGCACGGCGACGCGCTCGCGGACCTCGACTGGCGCGGTCTGGTGATTGAGGCCGACCACCACAAAATCGAGCGGTGCGGGCTGCGGCACCGTACGCCGGGCGAGCAGGTGCTGGGCAGTCGGACACGCGAGCGTCATGCCTGCGCCTCTGGCCGGGCCGTCCGCAGACCGCGCGGCGTGAGGGAAGCAGAGAACAGGAGCATGTTGGGCAGCATAGTCTTCCGGCGCGGGGCGCGCGTCCCGTACCGAACGGTAAGAAAGCTGTCTGGGTCGCCTTTTTTCGTTTCCGGGATTCCTGGGATGCGGGCCCCTGACATGACGACACGTCCTTCTGACGCTACCCTGCAACCGACCTATGACTGCTCCTCCCGCCTTGCAAGACGTGTATGGCGTGCCCATTCCACCCGGCAGGCCGCTGGCCCAGGGCCGGCACGCCGACCTGCTGACCCTCGGCGAGGTGCGCGGGCAGGTAGCGAAGGTCTACCTGGCGCCGCCGCCGCCCGCCCAGGCCCAGAAGGTCGAGGAACTGGTCAAGGTGCCGCCCCACCCGGACGTGGCCCGGCGCCTGGTGTGGCCGCTGGCCGCGCTCTACGGCCCCAACCGGCAACTCGCGGGGCTGCTCTTGCCCCTGCTGCCGCCCCAGCAGTTTCAGGGGGTGCGGGCGCTGCTGCGGGCCGACACGCGCCGCCGCAGTTTTCCGGAGGCCGACTGGCCCTTCGCCGTGCGGGTCGGGCGCGAACTGGCGCTCGCCTTTGCCGAACTGCACGCCGCCGGGCACCACATGGGCGACGTGCGGCCCGAGCACGCGCTGGTGTCCGACGCGGGCGAGGTGCGGCTGGTTGGGGCCGACGACTACGCGCTGCACCTCGCTGGGCGCGACTTTGCCGGGCCGGTGGCGAGCGCGGAATATCTGCCCCCCGAGCGTCAGCGCGTTGGGAGCGCCACTGGCGCTGGGGCCGACGCCGAGAGCGACGCCTTCGGGCTGGCCGTCCTGCTGTTCGAGCTGCTGCTGGGCCGCCACCCCTACGCCGGGATTCAGGCACGCGGGGCGGCGCCGGGGCCGGGCGGGGCGATTGCCGCCGGGCTCTTTGTGGACGCGCCGCAGGCCGGGCCAGGGCGGCGGACCGCGCCGGGCGAGTGGCCCTTCGCGGCGTTGCCCCCGGCGGTGCAGGCGCTGTTCGTGCAGGCGTTCGCGGTGCCGGTGGTCCCCCGCCCATCTCCCGAAACCTGGGCAGCGGCGCTCGGCGCTCTGGCCGCCGAACTGGTGCCCTGTGCCCGCCGCGCCGGTCACTGGCAGGTGCCGGGGCTCCCTTGCCCGAGTTGCGCCGCCGAGCGCGAGGGGCCGGCGCCCAGCAGCGGGGAAGACGTAACGGCGCGGGTGCAGCGGCTGTGGAACGACGTGCAGCGAGTGGTCGCGCCGCCGCCGTCGCCCCCGGTGGCCCCGGTCATCGAGGCGCCGCCGCTGCCCCCGCTGCCGCTGGCGCTGCCCGACAAACCACGGGGTTTAAACCACCGCCAGCAGTTGCAACTCCTGACCTGGACGCTGCGGGTCGCCGTCCTCGCCGCGCTGATGCTGGGGGTCGGGCTGGTGCAGCGCTCGGTGCTGGCGGGGCTGGTGGTGCCCGCACTGATCGTCTTTGCCCTCACGCTGGGGCGGCGCTTTGCGGTGGACTGGGACGGCCTGATCGACCGTTACGAGCGCTGGGAACACGACCTCGTGCGGGGGCTGTTGCCGCGCCGGGGGCCGCAGCAGCGCTACCGCCGGGCGGTGCGGCGGCGCCGGGCCGAGGTGAAGACCGAGCTCGCCGCCCGCGTCGCCCAGCGCGAGGAACTGCGTGAGCGCTACCACGTCGAGAACGCCGCCGCCCTGCACCTGCGCGAGCAGCAGGCGTTGGAGCAGCGCCGGGCGCACCTGCTGAGCCTCAGCGCGGGCGGGAGCCTGGAGGCGCTACTGGGCCGCTGGCGCGAACGCTCCCGGCAAGACTATTTGCGCCAGCAGCAGCTCAGCAGCAGCGGCGTGCCGGGCGTCGGCCCCCGCGAACTCGGGCTGGCGGTGGCGCAGGGCATTCGCACCGCGTTGGACGTGACCGCCGAGCGGGTCCGCGCTCTGCCTGCCCCGCTGGGCCGCGAGTTGCTGGCGTGGCGGCGCGGCCTGGAAGACTTTTTTCAGTTCGACCCCGGCGCAGTGCCCCGCGCCGAGCTCAACGCCGTACAGCAGCGCGGGCAGCAGCACCTCGGCGACGAAATCGAGACCTTCGAGCGGGCCGTTCATGCCTACACCAATGCTCGCTGGGACCGCCACGAGGCCGAAATTTCCCGGCAACTTGGCGTCGTCGAGCGCGAAATCGAGCAGTACAAAAAGGCGCTGAGCGAACTGCGGGCCATCAAGGTCTGAGCCTGTGCTGTTTGGCACTTTTTCGCCTTCTTTGCACCCCGTCTCAACATCGCGGGGGCGAGCACAAGGGCGCGAAATACTCTCTTGACCCCGTGTCGCGCCTGATTGGTCCGGCTCGCGGGGCACAAGGTGAACCATGACTGACAAGGCACAGACTTCTCCGGCGCGCCTGCCCCGCATCATTCAGGGGGGCATGGGCGTGGCCGTTTCCGACTGGCGGCTGGCGCAGGCGGTGTCGCGCACCGGCGAACTCGGCGTGGTGTCGGGCACCGGCATCGACAACGTGCTGGTGCGGCGCCTTCAAGACGGCGACCCGCAGGGCCACGTCCGCCGGGCGCTCGCCGAGTACCCCAACCCGGCCAAAGCGCAGGAATTCATCGCCAAGTATTTCCTCGAGGGAGGGCGTGCCGAGGGGCAACCCTACGCCCGCGTGCCGCTGCCCAGCCACCGCAACCACCAGCTCGCCTGGGAACTGTCTATCGCCGGGGCCTTTGTCGAGGTCTGGCTCGCCCGCGAGGGGCACAGCAATCCGGTGGGGCTCAACCTGCTCACCAAGCTCGAACTGATGACCCTGCCCTCGCTCTACGGCGCCATGCTCGCCGGGGTGGACACGGTCATCATGGGCGCGGGCATTCCGCGTGAAGTGCCCGCCGCGCTCGACAACTTCGCGGCGGGGCGGCCCGGCACCTTCAAACTCAGCGTGAAGGGCGACCCACAGGGCGACACGCCGGGCGTGACCCTCGACCCCGCCGCTTACGGCTTTGACGGAGTGACCACTGGGCGCCCGAAGTTCTACCCCATCGTGACCTCGCACGTGCTCGCCGGGGCGATGCTGCGCAAAAAGACCGGCGGCATCGAAGGCTTTATCGTCGAAGGCCCCACGGCGGGCGGCCACAACGCGCCCCCGCGCGGCAACTACGCGCTCGACGACCTCGGCCAGCCGGTCTACGGCGAGCGTGACGTGTGCGACCTCGGCGAAATGCGCAAATTCGGCGTCCCCTTCTGGCTGGCGGGCGGCTACGGCAAGCGCGGCGGCCTGCAAGACGCGCTCGCGGAGGGCGCTGCCGGCATTCAGGTCGGCACGCTGTTCGCCTACGCCCAGGAAGCGGGCATCCGCGACGAGTTGCAGCGGCGGGTGCTCGGCGAGGTGCAGCAGGGCGACCTCAAGGTCTACACCGACCCGCTCGCTTCGCCCACCGGCTTTCCCTTCAAGGTGGTGCAGCTCCCCGAAACACTTTCCAACCCTGAGGTCTACGCCCGCCGGATGCGGATTTGCGACATCGGCTACCTGCGCGAAGCCTACTGGGACATGGCCCCCGGCAAGGAAGGCAAAGTGGGCTGGCGCTGCGCCGCCGAGCCGGTGGACCAGTACGTCGCCAAGGGCGGCAAGGTCGAGGACACCGTGGGCCGCAAGTGCCTGTGCAACGCCCTGATGTCCGACGCGGGGCTGCCACAGATTCAGAAAAACGGCGACGTGGAAAAGTCCCTGCTCACCAGCGGCGACGGCCTGACCGAACTCGGCAGCTGGAAGCCGGGGTATACGGCGGCGGACGCTATCGAGTTTTTGCGCGGCTGAGGTGCGGCGAAGCAGGCTGGTCTCCTTCCTGCTGCTCGCCGCTGCCGTAGTGGGAGCAACGCTCAAGGTGGTGAAGGATGACCGAAGCGCCGTCCGCCTACCCCCTGCCGTGTACGTTCCGCCAAGCGGTCCCTTGATTGAGCCCAAGGAAAATGCCGGACGTTGCCTTGCCACCGCCAAAATCACGCTGCCCAAGTCCTACAACGCCTTTGCCAACCACTGGCGTTTTACGGAAGCTAAACAACTGACCGCCGAAACCTGGCAGATTCGCGGCGAACTGAGCGAGTATTCGGCGACGGGCGTCAAGGTGTTTATTTTTCAGTGTGTGGATAGCAATGAAGCGACGGGGGTAGAGCTTCACCCGAAGTAAAAATTGGGCAAGTTGGGGGCCAGGGCTGCGGCGTTGGCCCCTTTTTCCTATTGTCCGATCTCCCCCAAAATCTCCCCAATCACCTCTTCCAATCCCAGCGGTCCGGTGTCGATCACGCGGGCGTCGGGCGCGGGGGCACTCTGGGCGGCGTCCTTCCTGTCCCTGGCGATGAGGG
+>2_1#NODE_19_length_33054_cov_76.4496_ID_37
+GGCCTGTCCGGCTGACGTGCTGGCTGCGCGTGCTGAGTCCGCAGCATCAGCCGCATGGGTTGCCGCCTCACGGGCTGATGTGCTGGCATCACTGGCTGACTTCTTCGCGGCTGCCGTGTTCTGTGCCACCGCGGACGCGTTACGCGCCACCTCTTCCACCATCAGTTCAAAACGGCGCAGTGCCTCCGGACGGGCATCATCCTCCGTCATGGCACCGAGAAAATCATTCAGCGTACCGGGTTGAGAATCTTCATACACGGTAATGGTCCCGGCATGTGACGGCGGGAATCCTTCCACCAACAGAATAACGCTGTACTGACCGTACTCAACGTCCATGCTGTAACGCCCGGCTTCATCCGGATTTTCTGAGGCCAGCGTGTTCACCACCACCGTGGTGCTGTTACGTTTTGCTTTCAGCTGGATTGTGCAGTTCTGTACCGGTTTTCCTGTGCCGTCTTTCAGTACACCTGAAATCTTTACTGCCATATTCACCCCACAAAAAAGCCCGCCTGAACCGGCGGGCTGTCATAACACTGTGTTACCTGGCTAATCAGAACTTATAACCGACACCCACGATGAAACCGTCAGTGCGCCAGTCGCCACTGCCGGGGCCTTCATAAGCAATATCAATGGCCACGGATTCGGTCGGGTTAAACTGCACGCCAGCTCCCCACGCCAGAGACGTGTTGCTGTGGCGACCGTCATCACTTCCGGTCAGCACGTCGTGCGTTTTCCCCTTGGGAAGGTGCGAACAAGTTCCTGATATGAGATCATCATATTCATCCGGAGCGCATCCCAGAGGGACATCATGAGCCATCAACTCACCTTCGCCGATAGTGAATTCAGCACTAAGCGCCGTCAGACCCGAAAAGAGATTTTCCTCTCCCGCATGGAGCAGATTCTGCCATGGCAGAATATGACCGCTGTCATCGAGCCGTTTTATCCCAAGGCGGGCAATGGCCGACGGCCCTATCCGCTGGAGACCATGCTGCGTATTCACTGCATGCAGCATTGGTACAACCTGAGCGACGGTGCCATGGAAGATGCCCTGTACGAAATCGCCTCCATGCGCCTGTTTGCCCGATTATCCCTGGATAGCGCCCTGCCGGATCGCACCACCATCATGAATTTCCGCCACCTGCTCGAGCAGCATCAACTGGCCCGTCAATTGTTCAAGACCATCAATCGCTGGCTGGCCGAAGCAGGCGTCATGATGACCCAAGGCACTTTGGTGGATGCCACCATCATTGAGGCACCCAGCTCTACCAAGAACAAAGAGCAGCAACGCGATCCGGAGATGCATCAGACCAAGAAAGGCAATCAGTGGCACTTTGGCATGAAGGCCCACATTGGTGTCGATGCCAAGAGTGGCCTGACCCACAGCCTGGTCACCACCGCGGCCAACGAGCATGACCTCAATCAGCTGGGTAATCTGCTTCATGGAGAGGAGCAATTTGTCTCAGCCGATGCCGGCTACCAAGGAGCGCCACAGCGCGAGGAGCTGGCCGAGGTGGATGTGGACTGGCTGATCGCCGAGCGTCCCGGCAAGGTAAAAACCTTGAAGCAGAATCCGCGCAAGAACAAAACGGCCATCAACATCGAATACATGAAAGCCAGCATCCGTGCCAGGGTGGAGCACCCGTTTCGCATCATCAAGCGGCAGTTCGGCTTCGTGAAAGCCAGATACAAGGGGCTGCTGAAAAACGATAACCAACTGGCGATGTTATTCACCCTGGCCAACCTGTTTCGGGTGGACCAAATGATACGTCAGTGGGAGAGATCTCAGTAAAAACCGGAAATAACGCCAGAAATGGTGGAAAAAATAGCCTAAATAGGCTGATTCGATGTGTTTGCGGGAAAAAAATCGGCCCAGATCCGCGAAATTTTAATCAGCGAGTCAGCTTGGGAAGAAATGACCTGCTTATTCGCACCTTCCCTTGTTGTCAGTTACGCGGAGATAATCCCCGGAGAAAGTCGACACACGGCTGTAAGCCATACCCGCCATCGCATACGCGCTGAACCATTCATTCACGCGCACAGACGGCCCCACCATCACGCTGAACCAGCGGTTACGCACGGAATCTTCATGCCAGCGGGTATCGCTGTAACGGGTAAGCTGGCGATTCTTGTCTCCTGCATAGCTGAATGGCCGCCCTGCTGCATTAACACCATAAATGGCGACTGACCAGTGGACAACCCAACAACAATATCCGTCATTTGTGCAGGCAACATGCGCATAGCAAAAGCCGTTTGTTTTGCCGACATTCCGGTTTTGCTTAATTGTGATTGAGTAACCTCAAGCTCACTCCGCATAGCACGAAGTTTTCCAGAAAGCTCCTCATACATTTCAGGAGAAAGCATCCCCTTAGCTTTTGCTTCATTGAGCTGTTTCTGTTGTTCTACCAGACGATTAAAAGCAGTTCCGACAGGATCAAGTTGAGCAATCAGACGTTGCAAAGCAACAACCTGTTCATCATGCGCTTTTGCTGCTTCTCGCTCTGCCTGAGCCTCTCCGGTAAGCTCTCGCCGTGTTTCCTGTATTTTTCGGCTATAATTCTCAAACTGAGAACCATTTATTTTCCCGGATGCAAACGCAGCATTAAGTTCATCATGCTGTTGTTCAAGATTTCTTAGCGCCGCAGCCAGAGGGTCGATCTTGTCCAGCATTCTTTGAAAGGCCTGAGCCTGCGCTTCCTGCTGAGCGGCAGCAAGTTTTCCGGCCTTCTCGGCTTCTCTCTGCGCTTGCGCAACCCCGCTCAATTCCTCTGTGGTTTCATTAAGTTTACGGACAAGAAATTCATATTCTTCTTTATCAATAAGCCCTTTATCGAAAAATTTCTTTAATTCAGAATAGCGTCGACCGACAGTATCAATTGCGGCACCAACTGGATCAATAGCTGCTTTTAATTTTGCGAGCGCGTTCTTCTCATCTTCTGTTGCCTTAGTCACTTTCCCTGCGCTATTTGCAGCAGTTTCCCCAGCCTGCGTCATTTTGACTAATGAGGAGGTCAGATTGTCAGCATTATTTTTCGCTCCAGTGCTATCAATAATTATTGCGAGACGCGAGGTTTGCTCTGCCATTTATTAAAACTCCTGACAACAAAAAACCCACCGCGAAGTGGGTTTCAGGCGACATAATAGTAGATATAGCGATTACGAGGCCACGCAATGCTTTTCTCCAGGAGCATCATCGATTTAATTAAAGACACCATCACATCTCTGTAACAGAGTGTACGTAATTAACAACTACACACACTGCTCCTGAAAATACTGGTCATCCAGTGCAAAGATCACTGCTTCAAATTCATCGCGCTCAATCAATACCGGATGAGTGGCTAAATATTCATTTATCTCTGTCAGAGATAAAGGCAAAGGCACCCCAGCCATTCCAGCATAACGTCGGGCACGGGATATTACCGAATAGGCGTACAACAACTCCTTAAGCACCGGGTCTATTTCTGGTTCCGGTATCGGTGGCAACCTGAGTTTTTCTCGCTTCCATCTTGCCTTTTCCCCCCTTTCTCCCCCGAACTCCGATAACCACCGCTGGGCAGCTATGGCTTTTTTATCGTATCCTGCTTCTGCTGCTCTTTACCCTGGGCGATGCTGGCTGCTTCTGCAAGGATCTGCCAGTACAACTCTGGATTCTGCTTAAGCAGCGCGATCCCTCGTTCTGCCGTATATTCCAGTGCAACCTCAACACCATTAACCAGTTCACCAACCCCTTTCCAGTCTTTCAGCAGATAACGAGCGGCATTATCAATGAGTAAATCATCAACAGAATCCACCTCGGAAACCTTTGAAATATCAAACTCCTTCGTTCCGACGTGCAAACTGGCATCCATTTTCTCAATGTGGCGACGGATTAATGCATTACGGGAGCGATACTGATCGTTATCGCTGCTTCTGCTCATCCGTCAGGCCAGACAGAACAATGACCGGAACAGAATCCATTTTGAGCATTTCAGCCGCCATAACACGACCGTGACCCGCAATAATTTCGCCCTTTTCGTCAATCAGCACCGGATTAGTCCAGCCGAATTGCTTAATACTTTCTACCAGTTGTGCCACCTGCTCAGTACTGTGCGTCCTGGCGTTGTGCGCATACGGTGACAATTCTTGTAATGGGCGATAGACTATCTTTAATTTCTCGCTCATACAGCCTTGCTTTATGAATAAAACGCACCCCAGCAGCCAGTGCTACTGGGGACGGAGGTGTTGCTGGTAAAGTTAGGTATTGGATCAATGAGTGAGTCAACATAATATTAAACTCACAATTATAAATCAGCCATATATTAGGAGCGCCAAAAAAAACCTGAAAACAATATAATAACAGGATAAATTTCAAGGCGACCAAGAATCATAGCTATGCACATTAAGCATTTTGCAATGTCATTAAGCACTCCGAATGACGATGCAGTAGCCCCAAAACCTAATCCCATATTATTAATACATGCAGCCACTGTTGCAAATGATGTAAGAAAATCATATCCCATACCATTTAACACCAGTATAAAAAACACCGTGAAGAGAGTATAAAGAAAAAAGAAACTCCATACAGACCTCATTACACGATCTGTAACTATCTTCCCTCCTACATTTACACTCAACAACGCTCTGGGATGAGAAAGCTGATTTATCTCGTGTTTGCTTTGTTTGAAAAGTATAAGAAATCGAAGTGACTTAATTCCACCACAAGTTGAACCTATACATCCCCCAAAGAAACTTGACAACAGCAAAAACACTATCGTGTGCGTGGGCCAACTTGCATAATCCTGCGTAGCTAAACCATTATCAGTGAGCATGGAGCTGGCAAGAAAAAACGAATGAATAAAACTTCCATGCAAGTCATACATACCTATATGCCAGACCTGGAAAGAGGTAACAATGATCACCCCTAAGGCTATTAACAGAAAGAAACGAAGTTCAATATCTCTGATTAAAGGTTTTATCGTTTTCCTGCTAATAACAATATACCAAAGAGTGAAGTTGAAAGCCGATAGCAGGGAAAAAGAACCAGCCACCAGCTCAACCAAATAGTTATTAAAATATCCGATACTCTCGCTATGAGTTGAGAAACCACCAAGCGAAACTGTGGAAATCCCGTGACAAATAGCATCAAACAAAGGCATTCCTGCAAGTCTATAACAGACAATACAAGCAATACCTAATAAAGAATAAGTTATCCACAGTGTCCGTGACGTATCGGCCAGGCGGGGAGTGAGTTTGTCATCCTTAAATGGCCCCGGCATTTCTGACTGATAAAGCTTTGCACCACCAATACCCAATAATGGCAATACAGCAACCGCCAGAACAATAACTCCTAAACCACCTATAAAATTTAACTGTGACCGATAGTACAAATATGCCCGAGGTAATGAACTAACATCATCAATTACAGTTGCTCCTGTTGTTGTTATTCCAGAAACCCCTTCAAACAGAGCATCAATGAACGTTAAATTAAGTTCTGAGTCAATCCATAAAGGGAATGCACTAATAACAGAAAACAAAATCCAAAACATTACAATTATAATAAACCCATCACGGGTACGTAATTGAATGCCAGATTTCTTAGTTGTATACCACGCTCCGCCACCAATGCAAAAAAATATAACGAAAGTTATAAAGAAAACAAACAGGCTTTTTTCTTTATAAAACAATGCTACAACCATTGGTGGCAACATTGAAAGACTATAGAGCCAAACCAGGAACCCACACATATGAGTAACAACTCTTACATGAGATGTATTCATATCTAAATATTCTTTCAATTATAACCACCTTGCTGCAATATTATGATTATACTGTATAAAATTTAACTCCTCTTAGATCTTACTTCACTGTTCCTTATGAAACAATCATCAAAATGAATCATATTGTAGTTAAGATTTTACTTTAAACACTGCTCGGTTATGTATTGCTGAGCACCTTCAAGTTGGGCCTGCATCATTACCAGTCGTTCCCGGAGGGTGAAATAATCCCGTTCAGCGGTGTCTGCCAGTCGGGGGGAGGCTGCATTATCCACGCCGGAGGCGGTGGTGGCTTCACGCACTGACTGACAGACTGCTTTGATGTGCAACCGACGACGACCAGCGGCAACATCATCACGCAGAGCATCATTTTCAGCTTTCGCATCAGCTAACTCCTTCGTGTATTTTGCATCGAGCGCAGCAACATCACGCTGACGCATCTGCATCTCAGTAATTGCCGCGTTCGCCAGCTTCAGTTCTCTGGCATTTTTGTCGCGCTGTTCTTTGTAGGCGATGGCGTTATCACGGTAATGATTAACACCCCATGACAGGCAGACGACGATGCAGATAACCAGAGCGGAGATACCGATGCTGCTTTCGGCTCTGCTGGTAAATTATCGCCCGGTATGCAGTAACGAAATTTACCGCCCTGATTTACGCGAATCAGACGACCTTTGCTGATTGCCATTGCCAGCGTTGAAGCCACTTTGCGTGATGTGGTACCAAACAATGTAGCCAGCTCATCAGCCGTTTGTGGTCCTCGTTGTTCAATCGTCGCGGTTAAATCGCACTCTGAGATTTTCGCTACTGTTGCTGTGGTGATTTCTTCCGGCAGTTCTGCCTGCGCTGGCTGTTCCTGCTGAACATTGTTATCAGCCACACGCCAGGTGTACGCGCTTTTATCAACAAAACCAGCCTTTTTCAGTTCCCATAGTTCGTTCAGCACTTCTTCACGACTGATATCAAGTCGCGCAGCAAGTTCTATGGATGTGGCTTTTCCCATTGCTTTCAGTGCGTCAAAAACAGTCTCCATTAAATTTTTCTCCCGGTAAAAATTACTTCGCAATTCCTGGCTGGACGACATTCGGACGCCAGCTCTCCCAGTTAAAATTCACCCATCGCCCGCCGTTCATGGTCATGCGATCCATAATCCGCTCGCCGAGCAATGTTTTCATGGCCTCATAGTTCAGGTTTGTCAGCATCCCCACGCTGCGCATCGACGCTGTCCGGCGATCAACAATCTGGTGCAGTACCACCTGCTCGTTTTTCGTCTCGCGCTGAATGCCAATTTCATCAAGAACCAGCAGATCCACTTCGCACAGTTCCCGCAAAAATTTTTCGCCTGACTGCCCATCGTCATAGCTGGCGTGCAGGGCACTCATAACATCAGCCACGGTAACCACAATCACTGTCTGACCGTCTTTCAGCAGGCGATTCCCGATAGCTGCCGCTAAGTGGTTCTTCCCGGTACCAGGTTTTCCGCTGAACGCAAAATTTGTACACCCGGTCATCAGTTCATCAGCGATGGATTTCGCCTGACTCAACGCGTATCGCTGCCCTTCGTTCTGCACCTGGTAATTCGAAAACGAGCATTTGCGGTGCAATGGCTGGATGCCAGAGCGATTCAGAATTTTTTCCACCCGCAACTGACGATTCTGACGGTTGATCTCCTCACAACGTTTCTGGCCTTCGGAAAGTTGCCACTCGCGCCACTCCGCTACCGTCTTGAATGGCGCGGTTACATGTGACGGGGCCAGTCTGCGGATACGTTCAAGAACATCGCCTGTCGCAATATTTTTCATGGTCAGTTACCCCCTGAAGCCTGGCGGGATCGCACTATCCGGTAACGAGACGGTGTTAACCTGTCGGAGTAACGTCTCAGGTCGAACACCTTTCGGCGCGAACAAGCCCTGGTATTCATTGGCGATGCTGTGTCGAATCACCTGCTCAGGTGAAAAACCCTGCTGGCGGAATTTTTCCAGCTCCCGTATCGCCCCGTTAGCGCCCTGCTCCGTTCGAATCGGTTTTCGCAATGCCTGGCGAAATTCAACCCACTCACGCCAAAGCGAGACAGAAATCCAGTTCGGCAAAGTAATATCCAGAGGGTCAAACTTTTTGACACCTCGATTCCCCCGGGGGGGATTTAGGGGGGGATCTGTTTTTAGATCTTTATCTGTATCTTTATTAGTTGCCTTTGTGTTGACATCATGTTCAAACACCACTTCAACATCTGTTTGAACACCTGTTAAATTTCTCTCTTGTTTTGTTTGAACATCTGCTTCCTTTCTGCTTCTTCTGGCCTGAACAGATGCTTTTCCTGCGGCTGATTTTTTGGTTAATTTTTCCCTGACTGATGCCAGATCTTCCTCAATCCGAAGATGCACCCATTCCTCGCCGTTATCGCAAAAAAACTCCTGCAAGGATGGTTCAACATCAGCCCATCGCTCGTTAGTCAGACGGGCAATTTTTGCCAGCCTGTTTTTAGGTATTGGCTTTCCTGTTTGCCAGTAATTGAACATCAGCAACAAATACGCACCATGCTCCTCTGCTGACAAATGCATGGTGTCAGCCAGGTAATCAGCTATGTACAGTTGCATGTATGGTAATGCGGCCATAATTGCCCCGTATGATGCTGCCCGGTGGCTTAGAATAAGCACAAACAGCATGGAAACTTTTGCTTAATGAACAATGACAGAATCGTCGGAAGAACCGCCGCCGCTGAAATGCGCTTTCCGGTAAACGGCTTGGACTGCATCATCATGCGCATCAATTGCCGTACTTAACGCTTCCTGCGCCGCCAGTAATGCACGGCGTTCCAGGGTATCGAAGATGCAGAGTCGGTGACGCAGCTCGCGCGGAAGGATTGCCAGAATTGCTGGGATCAGCTTCTGAATTTTTTCTCTTTGCGTTTTCGTTTCACCTTTCAACCAACGGTGATAGATATTCTGCTGATTGTTCCAGTCCTTGCCTGGAACCAGGGGCAATTCGCCGCCCCCCTGGCGCAGATATTCTTCAGTAATTGCATTGGCTACCCATGCCTGCCCTTTTTCGGCTGCTAGGGCAAACAACACTGATTCGATGTGCTCATGCTTGATTTTCATGAATCATTTGCCTCTTGATGTTTCAGGTATGATCAAATGAGGATTTGTTACTGTCATTTAGTTGCTTCACTGACATATTCTGCGAACAACATGCCGAACGTCGTAAATATGACCAGTCAATATCAGGACGAAGTTCTTCGCACAGAACCTCACCTCTTGTTGCACGTTCAATTGCTGGACATCTCTCGGCAGGCAATTGACGTACCCCTTTGATCCATTGATTTACGCTTGGAGGTGATACACCTAAAAGCCTAGCCATTGCTGATTGCCCACCGACAACAGCACAAGCTTGCTTGAATGAATAGTTCTCTTTTTTCATCGAATGAACTCCAAAAACACACAGAAATATTAGGCGACGCCTAACGCAATTGTCAATAGGCTGTGCCTAATGCAGTAAGGGTAGGGATTGCCTAATGTAATGCGCATAGGAGAATATTAAGCAATGCTTAGTGGTAAAGACTTAGGCCGAGCGATAGAGCAGGCCATTAACAAAAAAATCGCATCGGGATCCGTCAAATCAAAGGCGGAGGTCGCACGCCACTTTAAAGTCCAACCACCATCAATTTATGACTGGATTAAGAAAGGCTCTATAAGTAAAGATAAACTTCCAGAATTATGGCGTTTCTTTTCTGATGTTGTTGGTCCAGAGCATTGGGGGCTTAACGAATACCCCATACCAACCCCCACCAATTCAGATACAAAAAGTGAACTTTTAGATATAAACAACCTTTATCAAGCAGCCTCTGATGAAATAAGAGCGATTGTAGCTTTCCTGTTATCTGGAAATGCTACAGAACCAGATTGGGTTGACCACGATGTTCGCGCCTACATAGCAGCGATGGAAATGAAAGTGGGTAAGTATCTGAAAGCTCTTGAATCTGAACGGAAAAGCCAGAACATCACAAAAACTGGAACTTAAACTTATATGGTCTGACGGAAAACTCCTGGATTCCGTTATTTAACCCCCCCATCACTTTCTGCTGTCGCCATCACCTATTAGGTTACGCTCAAAACATTAGGCATAGCCTATTGACAATCAATTAGGCATTACCTATAGTTCCAGCATACCACCCACCCCGCCCCACAGAACGCCGGGCAATACTTCGAGTTACCAGGCAGTGGTAAGGGGTTAAGTAGCCAGCCCGAGGCGTATGAACATGACGGCGGGATTCAAATTTTGCAGTGCAGCAGTTAGTTCCGCCACCCGGCGTTAAGGGGAGAGATAAGATGGTGCATTACGAAGTAGTTCAGTATTTGATGGATTGTTGCGGTATCACTTACAACCAGGCTGTGCAGGCTTTACGCAGCAACGACTGGGATCTCTGGCAGGCAGAAGTCGCTATACGTAGCAACAAGATGTGAGATTCGCAAAATGCAAAAAATCGACCTCGGCAACAACGAATCCCTGGTGTGCGGCGTGTTCCCCAACCAGGATGGAACGTTCACTGCCATGACGTATACCAAAAGCAAAACATTTAAAACCGAAACTGGTGCGCGCCGATGGTTGGAGAAGCACACAGTAAGCTAACGATTAAAACGTCTACTCCTGCTGTTCCAGAATAACTTCATAAAATGGGAGTATTTTTCGGTGACGAGATAATAAGAACAGTTTGCGCTATCACTCTGATGTTGAATGATGCCCTTCCGTTCTAATTTTTTCATAACCGGGTTACGGCAAGGAGAAGTGATAATAAGATTTCCTGTTTTAAGGAAATCTTTAAATACAGCGATTTCTTTCTCAGATAAACGAAGCAATACTCGTTGCTCTGGTAGTAATGAATAATGCTTTTGAATATGTGCTCGCAATCTTGAGAAGGAAATGGCGACCACGAAAGAAAAGGCAAAAACGATAATCTGAAAGAGCCAAGGTATTTCAGTATAAGCATTGAATGCGACAGTAAACTCTTTCGGTATCAGCCAGAGAGTGAGACCAAAAATGATAATCGTATACATAAGTCTTTCGAGTGGCTCGTTAGCAAAAAGTTTCAACAATGGAGTAAATACATCCAACATATCAATAACTCTCAACTGTAAGGGTATTGAAATGTTAACACAAGCTCTCGCTGTAGGGGTATAGCCGAGACCACCGAAGCCCGGAGGTGGTGAAATAAAACCGGGCACAACACGAAGGCGCATTTCCGATATCCATAAAGAGTCGGTCTTGTCTGTTAAATTTAAATGGTGGGAGTGCGCCTCCGGTTGTAAATAACGACATTGCTGTGTGTAGTCCTGGCGGCATCAGTTTTTTTCTTGAAGTTCGGCTGATGTCCGCCCTTTTTAAAGTGAATTTTGTGATGCGGTGAATGCGGCTAAGCGCACGTGGCACAGTTAAAAGTCATGTTAGTCCTTATTGGTTTGGGTGGGAAAGCCGACTGTAATTGTTAACTGGTTGCAGTCACCTGGAGGCACCAGACACCGCATCAACAAAGTTCATTTGTAAAAATGGAGATAATTATGATTGCACATCACTTCGGAACTGATGAAATACCACGTCAGTGTGTGACTCCTGGCGATTATGTTCTTCATGAAGGCCGGACATATATTGCCTCGGCAAACAATATTAAAAAGCGAAAACTATATATTCGTAACCTGACCACAAAAACATTCATTACTGACCGCATGATTAAAGTCTTCCTCGGTCGTGATGGTTTACCTGTAAAGGCGGAGTCATGGTGATGACTAAGAAAATAAAATGTGCTTACCACCTTTGCAAAAAAGACGTTGAAGAAAGCAAAGCTATTGAAAGAATGCTTCACTTCATGCACGGGATTTTATCAAAAGACGAACCGAGAAAATATTGCAGTGAAGCTTGTGCCGAAAAAGACCAGATGGCACATGAACTTTAATTAATTGACTATTCGAAACTGAATTTATGCCAGAAATGGCAGGTATTCGCTCAACCTTAATTAAGGAGAAAAACATGATTACCAATTATGAAGCCACTGTTGTAACTACCGATGACATTGTTCACGAGGTGAATCTGGAAGGAAAGCGCATTGGCTACGTAATTAAAACAGAAAATAAAGAAACCCCATTCACTGTGGTTGATATCGATGGTCCATCAGGCAACGTAAAAACACTTGATGAAGGTGTCAAAAAAATGTGCCTGGTGCATATCGGAAAGAATCTGCCCGCAGAAAAAAAAGCCGAATTTCTGGCAACTCTAATTGCAATGAAATTAAAAGGTGAAATCTGAAAGAAATAGCCTGCGTATGGCGCAGGCTATGAACAGTGTGTATCCGGCAAGATCATTCACTGAACAAAACGAATTTTAATCTGAGTTGAGGTTAAAAAACAATGAGCACAAAACCACTCTTCCTGTTACGGAAAGCGAAAAAATCATCCGGTGAACCTGACGTCGTCCTGTGGGCAAGCAACGATTTTGAATCGACCTGTGCCACTCTGGACTACCTGATCGTTAAGTCAGGTAAAAAACTGAGCAGCTATTTTAAAGCTGTTGCCACGAATTTTCCTGTCGTTAATGACCTGCCCGCTGAAGGTGAGATCGATTTTACCTGGAGTGAACGCTATCAACTCAGCAAAGACTCCATGACATGGGAACTAAAACCGGGAGCAGCACCAGACAACGCTCACTATCAAGGCAATACCAACGTCAACGGCGAAGACATGACTGAGATTGAGGAGAATATGCTACTCCCAATTTCTGGCCAGGAACTGCCCATTCGTTGGCTTGCTCAACACGGCAGCGAAAAACCGGTAACGCACGTTTCACGCGACGGACTCCAGGCATTACACATTGCTCGGGCTGAAGAACTACCGGCTGTTACTGCCCTGGCTGTTTCCCACAAAACCAGCCTGCTCGACCCGCTGGAAATTCGCGAACTCCACAAACTGGTTCGTGACACTGACAAAGTTTTCCCTAATCCTGGTAATTCAAACCTGGGACTGATAACTGCTTTTTTCGAAGCATACCTGAACGCTGACTACACCGATCGAGGACTGCTGACAAAAGAGTGGATGAAGGGTAATCGTGTTTCACACATCACTCGCACGGCTTCCGGTGCTAATGCTGGCGGCGGAAACCTCACCGATCGCGGCGAAGGTTTCGTACACGATCTGACGTCACTGGCGCGCGACGTAGCCACTGGCGTACTGGCCCGTTCAATGGATCTGGACATCTATAACCTTCATCCGGCACACGCTAAACGCATTGAGGAAATTATCGCTGAAAATAAACCGCCCTTTTCTGTTTTCCGCGACAAATTCATCACCATGCCTGGCGGGCTGGATTATTCCCGCGCCATCGTGGTTGCGTCCGTAAAAGAAGCACCAATTGGGATCGAGGTCATCCCCGCGCACGTCACTGAATATCTGAACAAAGTACTGACTGAAACCGATCATGCCAACCCTGATCCGGAAATCGTGGATATTGCCTGCGGTCGCTCCTCTGCCCCGATGCCGCAGCGAGTAACAGAAGAAGGAAAACAGGATGATGAAGAAAAACCGCAACCATCTGGAACAACGGCAGTTGAACAGGGAGAGGCTGAAACAATGGAACCGGACGCAACTGAACATCATCAGGACACGCAGCCGCTGGATGCTCAGTCACAGGTAAATTCTGTTGATGCGAAATATCAGGAACTGCGGGCAGAACTCCATGAAGCCCGGAAAAACATTCCATCAAAAAATCCTGTCGATGACGATAAATTGCTTGCTGCATCACGTGGTGAATTTGTTGACGGAATTAGCGACCCGAACGATCCGAAATGGGTAAAGGGGATCCAGACTCGCGATTGTGTGTACCAGAACCAGCCAGAAACGGAAAAAACCAGCCCAGATATGAATCAACCTGAGCCAGTAGTGCAACAGGAACCGGAAATAGCCTGCAATGCCTGCGGCCAGACTGGCGGGGATAACTGCCCTGACTGTGGTGCGGTGATGGGCGACGCAACATACCAGGAAACATTCGATGAAGAGAGTCAGGTTGAAGCTAAGGAAAATGATCCGGAGGAAATGGAAGGCGCTGAACATCCGCACAATGAGAATGCTGGCAGCGATCCGCATCGCGATTGCAGTGATGAAACTGGCGAAGTCGCAGATCCCGTAATCGTAGAAGACATAGAGCCAGGTATTTATTACGGAATTTCGAATGAGAATTACCACGCGGGTCCCGGTATCAGTAAGTCTCAGCTCGATGACATTGCTGATACTCCGGCACTATATTTGTGGCGTAAAAATGCCCCCGTGGACACCACAAAGACAAAAACGCTCGATTTAGGAACTGCTTTCCACTGCCGGGTACTTGAACCGGAAGAATTCAGTAACCGCTTTATCGTAGCACCTGAATTTAACCGCCGTACAAACGCCGGAAAAGAAGAAGAGAAAGCGTTTCTGATGGAATGCGCAAGCACAGGAAAAACGGTTATCACTGCGGAAGAAGGCCGGAAAATTGAACTCATGTATCAAAGCGTTATGGCTTTGCCGCTGGGGCAATGGCTTGTTGAAAGCGCCGGACACGCTGAATCATCAATTTACTGGGAAGATCCTGAAACAGGAATTTTGTGTCGGTGCCGTCCGGACAAAATTATCCCTGAATTTCACTGGATCATGGACGTGAAAACTACGGCGGATATTCAACGATTCAAAACCGCTTATTACGACTACCGCTATCACGTTCAGGATGCATTCTACAGTGACGGTTATGAAGCACAGTTTGGAGTGCAGCCAACTTTCGTTTTTCTGGTTGCCAGCACAACTATTGAATGCGGACGTTATCCGGTTGAAATTTTCATGATGGGCGAAGAAGCAAAACTGGCAGGTCAACAGGAATATCACCGCAATCTGCGAACCCTGTCTGACTGCCTGAATACCGATGAATGGCCAGCTATTAAGACATTATCACTGCCCCGCTGGGCTAAGGAATATGCAAATGACTAAGCAACCACCAATCGCAAAAGCCGATCTGCAAAAAACTCAGGGAAACCGTGCACCAGCAGCAGTTAAAAATAGCGACGTGATTAGTTTTATTAACCAGCCATCAATGAAAGAGCAACTGGCAGCAGCTCTTCCACGCCATATGACGGCTGAACGTATGATCCGTATCGCCACCACAGAAATTCGTAAAGTTCCGGCGTTAGGAAACTGTGACACTATGAGTTTTGTCAGTGCGATCGTACAGTGTTCACAGCTCGGACTTGAGCCAGGTAGCGCCCTCGGTCATGCATATTTACTGCCTTTTGGTAATAAAAACGAAAAGAGCGGTAAAAAGAACGTTCAGCTAATCATTGGCTATCGCGGCATGATTGATCTGGCTCGCCGTTCTGGTCAAATCGCCAGCCTGTCAGCCCGTGTTGTCCGTGAAGGTGACGAGTTTAGCTTCGAATTTGGCCTTGATGAAAAGTTAATACACCGCCCGGGAGAAAACGAAGATGCCCCGGTTACCCACGTCTATGCTGTCGCAAGACTGAAAGACGGAGGTACTCAGTTTGAAGTTATGACGCGCAAACAGATTGAGCTGGTGCGCAGCCTGAGTAAAGCTGGTAATAACGGGCCGTGGGTAACTCACTGGGAAGAAATGGCAAAGAAAACGGCTATTCGTCGCCTGTTCAAATATTTGCCCGTATCAATTGAGATCCAGCGTGCAGTATCAATGGATGAAAAGGAACCACTGACAATCGATCCTGCAGATTCCTCTGTATTAACCGGGGAATACAGTGTAATCGATAATTCAGAGGAATAATTCAGCCTGGCGGTGTAATGCACCGCCAACTTGAAATATTTTTTATGAGAAAAATTATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCGAGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAACCACTGGAAATAATAATGGAGGTGTTCATGTATAAAATTACCGCCACTATTGAAAAGGAAGGTGGCACTCCTACTAACTGGACAAGATATTCAAAATCTAAACTAACGAAATCAGAATGCGAAAAAATGCTCTCAGGTAAAAAAGAAGCAGGCGTTTCCAGAGAGCAGAAAGTAAAACTGATAAATTTTAATTGCGAGAAACTTCAGTCCTCGAGAATTGCATTGTATTCAAATTAAAACTTCATAGCTGATTATTAATAATCAACATCGGGCGTCAATTTCAGTCTAACATTGGCGCCTGCCAGAGGTGATGCGATGGCACAAGTAATCTTTAATGAAGAGTGGATGGTTGAATACGGCCTGATGCTTCGCACTGGTCTGGGGGCCAGACAAATTGAAGCATACCGCCAGAACTGTTGGGTGGAGGGCTTCCACTTCAAACGAGTATCTCCTTTAGGTAAGCCAGACAGCAAACGAGGGATTATCTGGTACAACTATCCAAAGATAAATCAGTTTATCAAAGACTCATGATATGTCTAAATTACCAACAGGTGTCGAGATTAGAGGTAGATACATTCGCATCTGGTTCATGTTTCGAGGAAAACGATGTCGGGAAACATTAAAAGGCTGGGAGATTACAAACAGTAATATTAAAAAGGCCGGAAATTTAAGAGCGCTGATAGTTCATGAAATAAACTCCGGTGAATTTGAGTATTTAAGACGTTTTCCCCAGTCCAGCACTGGGGCAAAAATGGTGACAACGAGAGTCATAAAAACGTTCGGAGAGCTTTGTGATATCTGGACAAAAATTAAAGAGACAGAGTTAACAACAAACACAATGAAGAAAACGAAATCACAATTAAAAACACTCAGAATAATAATTTGTGAAAGTACCCCGATATCACATATTCGTTATAGCGATATCTTAAACTACCGGAATGAACTGCTGCATGGAGAAACGCTTTACCTGGATAATCCAAGATCCAACAAAAAAGGAAGAACCGTGCGCACAGTTGATAACTATATCGCCCTGCTCTGTTCGCTGTTGCGTTTTGCGTATCAGTCGGGATTTATATCAACCAAACCATTTGAAGGAGTAAAAAAATTACAGCGAAACAGAATAAAGCCTGATCCGTTATCTAAAACAGAATTCAATGCATTAATGGAAAGTGAAAAAGGACAGAGCCAGAACTTGTGGAAATTTGCCGTTTACTCAGGACTTCGTCACGGGGAACTGGCAGCTCTGGCGTGGGAGGATGTGGATCTCGAAAAGGGAATAGTGAATGTCAGAAGAAACCTGACGATACTTGATATGTTCGGTCCCCCAAAAACAAATGCCGGGATCCGAACAGTAACACTACTGCAGCCTGCTCTTGAAGCACTGAAGGAGCAATACAAACTGACCGGGCATCATCGCAAAAGCGAAATCACCTTTTATCATCGGGAGTACGGCAGAACCGAAAAGCAAAAACTGCATTTTGTTTTCATGCCCAGGGTGTGTAACGGAAAACAAAAACCTTATTACTCGGTAAGCAGTTTGGGGGCAAGGTGGAATGCAGCAGTAAAACGTGCTGGTATTCGCCGCCGTAATCCGTACCATACGCGGCATACTTTTGCCTGCTGGCTGTTGACGGCAGGAGCGAACCCGGCATTTATAGCCAGCCAAATGGGGCATGAAACTGCGCAGATGGTGTATGAAATTTACGGTATGTGGATTGATGACATGAACGACGAACAGATAGCCATGTTGAATGCGCGGTTATCGTAGTTGCAAAGTTTGCCCCCAATTTGCCCCATTTAGTACCAGAGAACTGAAATAATGCAAGAAAATCAACAAATTACAAAGAAAGAACAATACAACCTGAACAAATTACAAAAACGTCTGCGTCGTAACGTGGGCGAAGCCATTGCTGACTTCAATATGATTGAAGAAGGCGATCGCATCATGGTTTGCCTCTCCGGGGGTAAAGACAGCTATACCATGCTGGAGATTCTGCGCAATTTGCAGCAAAGCGCGCCAATCAATTTTTCGCTGGTGGCTGTTAACCTCGATCAAAAGCAACCGGGCTTCCCGGAACACGTTCTGCCCGAGTATCTTGAAAAGCTGGGCGTTGAGTACAAGATTGTTGAAGAGAATACTTACGGTATCGTGAAAGAGAAGATTCCAGAGGGCAAAACCACTTGCTCACTGTGTTCTCGCCTTCGTCGCGGTATCCTTTATCGTACCGCAACGGAACTGGGGGCGACGAAGATCGCGTTGGGTCACCATCGTGACGATATCCTGCAAACGTTGTTCTTAAATATGTTCTACGGCGGTAAGATGAAAGGTATGCCTCCGAAACTGATGAGCGATGATGGCAAACATATCGTTATTCGTCCGCTGGCCTACTGCCGCGAGAAAGATATTCAGCGATTTGCCGATGCAAAAGCGTTCCCGATTATTCCGTGCAACCTGTGCGGTTCACAGCCTAACCTGCAACGTCAGGTGATTGCTGACATGTTGCGTGACTGGGATAAACGTTATCCAGGGCGTATCGAGACGATGTTCAGCGCGATGCAGAATGTGGTGCCGTCGCATCTGTGCGATACCAACCTGTTCGATTTCAAAGGCATCACCCACGGTTCTGAAGTGGTTAACGGGGGTGATCTGGCGTTTGATCGCGAAGAGATCCCACTACAACCGGCGTGCTGGCAGCCAGAAGAAGATGAAAATCAGTTGGATGAGTTACGGCTGAATGTGGTTGAAGTGAAATAACCAGGATAGCGCCCGATGCGCAAGCGTATCGGGCTACTCTTATGGAGGCCGGATAAGACGCGGCCAGCGTCGCATCCGGCAATCCCGAATAAGATGTTTACTCTTGCACCCGGCAATTCAACATTTCATTATTTTAATAACCGCACCCGGCACGTTTTTCCTTTAATCTTCCCGCCCTGTAACTGTTTCCATGCTTTATGAGCAACAGCCTGACGGACCGCGACATAGACATGCGCCGGATGCACGGCGATTTTGCCAATATCTGCGCCATCAAGCCCGATATCTCCTGTCAGTGCACCTAATACATCACCCGGGCGCATTTTGGCTTTTTTCCCGCCATCGATACACAACGTTGCCATTTCTGCTTCCAGCGTCGCAATGGAACTATTAGCTGGCGGCGTTTGCCAGTTAAGTTTTATCTGCAACATGTCAGAAATGATATTGGCCCGCTGTGCTTCTTCCGGAGCACAGAAACTGATCGCCAGACCGCTATTTCCTGCACGAGCTGTACGACCGATGCGATGTACATGAACTTCAGGGTCCCACGCCAGCTCAAAGTTCACCACCAGCTCAAGCGATTTAATATCCAGACCACGCGCAGCAACATCAGTCGCGACCAGTACACGGGCGCTACCGTTAGCAAAACGTACCAGGGTCTGATCGCGATCGCGTTGCTCCAAATCGCCGTGTAATGACAATGCACTTTGCCCTACTTCATTCAGCGCGTCGCAGACAGCCTGGCAATCTTTTTTGGTATTGCAAAACACCACGCAAGAGGATGGCTGATGCAAGCTTAATAACCGTTGCAACAGAGGAATTTTGCCTTTGCTGGATGTCTCATAAAATTGTTGTTCAATGGGTGGCAAAGCATCTGTTGAGTCAATTTCAATCGCCAAAGGATCGCGTTGCACTCGTCCGCTGATTGCAGCGATGGCTTCCGGCCAGGTTGCCGAAAACAGAAGCGTCTGTCGAGATGCAGGCGCAAAACGGATGACATCATCAATGGCATCGCTAAATCCCATATCCAGCATGCGGTCGGCCTCATCCATCACCAGCGTATTCAACGCATCCAGTGATACCGTGCCTTTTTGCAGGTGATCCAGCAAACGCCCCGGCGTTGCCACGATAATATGCGGCGCATGTTGCAACGAATCACGCTGCATACCGAACGGTTGACCACCGCACAACGTCAAAATTTTGGTATTTGGCAGAAAACGCGCCAGCCGACGCAATTCACCTGCCACCTGATCCGCCAGTTCACGCGTAGGACACAGCACTAAAGCCTGGGTTTGAAATAGCGACGCATCAATTTGCTGTAACAAGCCGAGGCCAAAAGCCGCCGTTTTGCCGCTGCCGGTTTTCGCCTGCACGCGAACATCTTTTCCGGCAAGGATCGCCGGAAGCGCGGCGGCCTGCACCGGCGTCATGGTTAAATAACCCAACTCATTAAGGTTCGTGAGTTGGGCGGGAGGCAAAACATTCAGGGTAGAAAAAGCGGTCACAATCTATTCTCGTGGTCATCGACGCAAAGTTAGCAGGCGCGTATCCTCGCAGATCTACGCTCACGATGCGACAATTTAATCGGTTCTTCATCGGGTGGTGGGTCAGGCATGGGTTGCGGGCGAGGGATCGGATCGGGCACTGGAACAGGATCGCCAGGAATCGGTTCAGGGACAGGAATTTGCAAATAAATAAGTGTCGTCATATTTCCCTCTGGTCATTGGGTGGACTCTTAAAGGGTAGACGCTGATAAATAACAGGCAAAAAAAAGCCGACTCATCAAAGTCGGCGTCGTACGAATCAATTGTGCTATGCAGTAATTCAAAAAAGGAAGTAAGACAATATGGAGCGCAACGCCCATCGCTTGACGTTGCATTCACCTGCAAGAGAGATATTGCCCTGAATGGGTAGAGAGTTTATTGACTTCGCTCAAACTTTGCGGCGTTTTTGTATACAGACAGCCGGAAAAATTGCTTTTGTTACAACCATTTACTACGATGCAACCATAAAGCAACACCACCAATAAGAACAACTAACAGAATACAAAAAATTGAAAATCCGAATTGCCACCCGCCGCCAGGGATCCCACCAAGGTTGACGCCAAATAACCCGGTCAGAAAGGTACTGGGTAAAAAGACCATTGCCATCAACGACATTGTATAGGTACGACGAGCTAAATTTTCCTGCATCACCTGAGCGATTTCATCCGCCATCACGCCAGTCCGTGCTATACAGGCGTCGATTTCGTCAAGGCCGCGCCCAAGGCGATCGGCAATATCCTGCATCCGACGGCGTTGGTCATCGCTCATCCACGGCAAACGTTCACTGGCAAGACGAGCATAAACATCACGTTGCGGTGCCATATAGCGACGCATCACAATTAATTGTTTGCGCAGCAGAGCCAGGAATCCACGCGGTGGAATTTGCTGATCAAGGAGATTATCTTCAAGGTCGATAATTTTATCGTGCAGCTGCTCGATAAATTCACTGGAATGATCGGTCAACGCATCGCACACATCCACCAGCCATCCCCCGCAATCGGTCGGACCCGTGCCCTCTTCCAGATCGCTCACCACATCGTCCAGCGCCAGCACTTTGCGTTGTCGGGTCGAAACAATTAACCGCCCGTCCATATATACACGCATGGCGACCAGTTGATCGGGGCGTTCATCGGTGCTGCCGTTTATACAGCGCAATGTAATCAGCGTGCCTTCACCGAGACGGCTGACTCGGGGACGCGTGCTCTCGCCCGCCAGCGCATCACGTACGTTATTGGGAAGCAGCGGTGTTGTCGCCAGCCATTGGGCGCTATCATGGTGTACATAATTAAGGTGGAGCCAACAGGGATGCGCTTCATCAATCACATCTGTATTTTCCAGCGGTTTAACGCCGCCTCTACCATCCAGCATCCAGGCAAATACTGCATCCGGGACATTAACGTCCGATCCCTTAATCGCTTCCACAGTGCCTCCATCATCAACGCATTATTTTGTAGTCTAGCCTTCTGGCCCTGTTACGCAACATCTCATCACCCCATTACCCTGAAATGATTAATAAAATTCTGTCTAAATTGAATACAAAAAGCAAAATGCTTTTCCGTATACAAACCGTGTGAAGTGTTAAATAGCGTCTATCATTATCAGAATTATCTGATCATATGACGTGGCTTTTTTGCGATCGGATAGCAACAAAAATTGATAAAAATAACGGGATCTCAATGATTACGCACAACTTCAATACCCTGGACTTACTCACCAGTCCTGTCTGGATCGTTTCGCCCTTTGAGGAACAGTTAATTTATGCCAATAGCGCGGCGAAACTGTTGATGCAAGACCTCACGTTTAGTCAGCTACGAACCGGACCCTATTCCGTCTCCTCACAAAAAGAACTGCCGAAATACCTCTCCGATCTGCAAAACCAACACGATATTATCGAAATCCTCACTGTTCAGCGTAAAGAAGAGGAAACAGCATTGAGCTGTCGGCTTGTTTTGCGAAAGCTGACAGAAACAGAACCGGTGATTATTTTCGAAGGTATCGAAGCGCCGGCAACGCTGGGTTTAAAAGCCAGTCGCTCGGCAAATTATCAGCGCAAAAAACAAGGTTTTTATGCGCGCTTTTTTCTGACTAACTCTGCACCAATGTTGTTGATTGACCCGTCACGAGATGGACAAATCGTCGATGCTAACCTCGCCGCGCTCAATTTCTATGGTTATAACCATGAAACGATGTGCCAGAAACATACCTGGGAAATAAATATGCTCGGGCGTCGCGTCATGCCTATCATGCATGAAATCTCGCATTTACCCGGTGGTCATAAACCTTTGAATTTTGTTCATAAACTGGCGGATGGTTCGACTCGTCATGTGCAGACCTATGCCGGACCGATTGAAATTTATGGCGACAAGCTCATGTTATGTATTGTGCATGATATTACTGAGCAAAAACGGCTGGAGGAGCAGCTGGAACATGCTGCTCACCATGACGCGATGACCGGATTACTGAATCGGCGACAGTTTTATCACATTACGGAACCAGGCCAAATGCAGCATCTCGCCATCGCTCAGGATTACAGCTTGTTGCTCATCGACACCGATCGTTTTAAACACATTAACGATCTCTATGGGCATTCTAAAGGTGATGAGGTGTTATGCGCCCTCGCCCGCACCCTCGAAAGTTGCGCTCGCAAAGGCGATTTGGTGTTTCGTTGGGGAGGCGAAGAGTTTGTCTTATTGCTACCAAGAACCCCACTGGATACCGCGCTTTCGCTGGCTGAAACTATCCGCGTAAGCGTGGCAAAAGTGAGTATTTCGGGCTTACCACGCTTTACCGTCAGCATTGGTGTGGCGCATCACGAAGGAAATGAAAGCATCGATGAACTGTTTAAACGCGTTGATGATGCTTTGTATCGGGCGAAAAATGATGGACGCAACCGCGTGCTGGCGGCATAAGCCGCGGATGCGTCTCGAGATCAACGACTGCGCTTAGCGTGGCGCTCCCAGTTTTCTTGCTTCGCCTGCGCCGTTTTACGTAGTGCGACGTAACACGCCCCGCTGCCGCCATGATGCGGTAGCGCGGTGCAATATGCCTGAACATCATCAAATTCGGTCAGCCAGCGCGCCACATAGCTGCGGACAATATTGGCATGCGATTTATCATCCCGCCCTTTACCATGAATAATCAGCACGTTACGCAAACCATCCGCCAGGGCTTGTTGAATAAAACTGAACACCATTTTGCGGCACTCTTCCACCGGCTGGCGCAAAAGATTCAGGCTCGCCTGTTGCGGATATTTACCACTGCGCAGCTTATCCAGCACCCCATGTTGCAACCCTTCCCGCCGAAACTCCAGCGGCTGACTTAGTGGGATGATGTCGAGAAATCCGGTGGTGAGGAAATTATCAAGCTGCAGCGTGTCGATACGCTGCGGCGCACGTTGGTTACGCGTTGGATGCCAGTGGACATCGGTAGCACGTTTCAGCGGCTGGACATCTTCCATGGCGTCAAGAAACAGCGATTTGTCGTCAAGGTTCATGTTACATCCTCCCGCAATTAAGAGCGCGATATGATAACCAGACCGGGTCGGTCCAACAACGTATTACCCAAATTTCCAGTAATAAGTTCCAAATATTGCCGATATTTTAAGCAAAATACTTATGCATGATTATTCATTCACGATATTAATAATGTAACTTATATTTTCGTGAAATCTGTCACTGAAGAAAATTGGCAACTAAAGGTTAAAACCGTTATAACACAGTCACCGGCGCAGAGGAGACAATGCCGGATTTAAGACGCGGATGCACTGCTGTGTGTACTGTAGAGTCTGGCGGATGTCGACAGACTCTATTTTTTTATGCAGTTTTAACTTTGCAGATAGCCGCATTCTCGCCGGAATTGCGTGATTAATGACGCGGTCAGTGGTGTCTGGCGACTATCACGCCGCTGAATCAAATAATAGGCCGCTTTCGGTAAAATTTCGCTAACCGGCAACATCACCAGCCCCTGTCCGTGCAAGGGATCGCAGCCCATTTCTTCAGGCAGTTTGCTGAGAAAATCGCTTTTTGCCACCAGACTGATACAGGCTGAGAACGTCTCGCAGACTACACCGACCTGTGGCGTTTGCGCCTGATCGTCAAGCAATTCACTCAACTGTTTGTAGTAGCTGCCGTGTGGCGTCGGCATTGTCCAGCTGTAATCCAGTAACTGTTTGATCGAACGGGCACCAATGGCGGGGTGTCCCGGGCGGCAAAAGATCGCGAATTGCTTTTCCAGTAATTTCTCAAAAGTAAATTCGTGGTCGTACGGTCCCTGATAATAGGTATTGATGGTGAAATCCAATTCTCCCTGACGCAATTCATTAATCATCGACACCAGTTGCCCTTCCATAATGCGTACTTTTACCTGCGGATGCTGCTGATGAAAACGAGATATGACAGCTGGCATCAGACTGCGGGAAATACTGGCCCCCATGCCGATATTAATCTGCCCTGCCAGTTGCCCTTGTCGTTGGCGAATATCCTCTTGGGCTGCGCGCAGCTCTTCAAGAATTAGACTGGCGTGCTGATAAAAACTTTCACCGGCATCAGTTAACGTCACGCCTTTACTACGGCGAAAAAAGAGTTGCGCCGCTAACCCTTCTTCTAGCTCCTGAATAGATTTACTCAGTGCCGGTTGCGACATATTCAACATTCGGCTCGCTCCGCGAATGCTGCCCTGACGAGCCACTTCAACAAAAGCCCGAATTTGATGAATTTTTACCTGAAAAGCCATGACGCCACCGATAACCGTTATTTATCAGACCAAAGAAACTGGCATCTACTTTAATGCAGATGATTGTGTCAGGGTAATTTATGAACGGTTAAAACTGTGAAAAATCAGTTAGTGATAAGTAAAAACTATCGCTACGTGAACCGGGTCACACTTTTTACTGATGACGGGAAAGGTTATGGAGTCTTTGAATCAATTTGTTAATTCGCTTGCCCCAAAATTATCGCACTGGCGACGTGATTTTCATCACTATGCAGAGTCTGGCTGGGTGGAATTCCGCACTGCCACCCTTGTTGCGGAAGAATTGCACCAGCTCGGCTATTCACTGGCGCTGGGTCGCGAAGTAGTTAATGAAAGTAGCCGGATGGGATTACCTGATGAATTCACTCTACAACGCGAATTCGAGCGCGCTCGTCAACAGGGTGCGCTAGCACAATGGATTGCGGCTTTTGAAGGTGGTTTCACTGGTATCGTCGCCACCCTGGATACCGGTCGCCCCGGTCCGGTGATGGCTTTCCGTGTCGATATGGACGCGCTGGATCTCAGTGAAGAGCAGGATGTCAGCCATCGCCCCTACCGCGACGGTTTTGCGTCATGTAACGCCGGAATGATGCATGCCTGTGGTCATGATGGACATACCGCCATTGGGCTTGGGCTGGCGCATACCCTTAAACAGTTCGAGTCCGGACTACATGGCGTCATCAAACTGATTTTTCAGCCTGCAGAGGAAGGTACGCGTGGCGCGCGGGCGATGGTCGATGCAGGTGTCGTAGATGATGTTGATTATTTTACTGCCGTGCACATTGGCACTGGCGTACCTGCGGGCACCGTGGTGTGCGGCAGTGATAATTTTATGGCAACCACCAAATTTGACGCGCACTTCACCGGTACCGCCGCTCACGCAGGCGCAAAACCAGAAGACGGTCACAATGCCTTGTTGGCGGCAGCACAAGCCACTCTTGCACTGCATGCAATCGCCCCGCACAGCGAAGGAGCTTCCAGAGTAAACGTGGGCGTTATGCAGGCAGGAAGCGGTCGTAACGTTGTTCCTGCCTCGGCGTTGCTGAAAGTGGAAACACGCGGGGCCAGCGACGTCATTAATCAATATGTTTTTGACCGTGCACAACAAGCGATTCAGGGCGCAGCAACCATGTATGGTGTCGGCGTTGAAACTCGTCTGATGGGTGCAGCTACCGCCAGTTCTCCTTCGCCGCAATGGGTCGCATGGTTGCAAAGTCAGGCGGCTCAGGTCGCGGGGGTCAATCAGGCCATTGAACGTGTTGAAGCGCCTGCGGGTTCCGAAGATGCCACATTAATGATGGCCCGCGTGCAGCAACATCAAGGGCAAGCCTCCTACGTGGTGTTTGGCACACAGCTGGCGGCAGGTCATCACAACGAAAAATTCGATTTTGACGAGCAGGTTCTCGCTATTGCCGTCGAAACGCTGGCGCGCACCGCGCTCAATTTTCCCTGGACGCGAGGTATCTGATGCAGGAAATCTATCGTTTTATCGACGATGCGATTGAAGCCGATCGCCAACGTTATACCGATATTGCCGATCAAATCTGGGATCATCCAGAAACACGTTTTGAAGAGTTCTGGTCAGCGGAGCATCTGGCTTCGGCGCTGGAATCTGCAGGCTTCACCGTTACCCGCAACGTAGGCAATATCCCAAATGCCTTTATTGCTTCGTTTGGTCAAGGCAAACCGGTTATCGCCCTGCTGGGAGAATATGACGCCCTGGCAGGTTTAAGTCAGCAAGCAGGTTGCGCGCAACCTACATCCGTGACGCCCGGTGAAAATGGTCACGGTTGCGGACACAATTTGCTGGGAACCGCCGCCTTTGCCGCTGCAATAGCCGTCAAGAAATGGCTGGAACAATATGGGCAAGGCGGCACGGTGCGCTTTTATGGTTGTCCTGGCGAAGAAGGCGGCTCGGGTAAAACGTTCATGGTTCGCGAGGGGGTATTTGATGATGTGGATGCGGCACTCACCTGGCACCCGGAAGCCTTTGCCGGTATGTTCAATACCCGCACGCTGGCAAACATTCAGGCATCATGGCGCTTTAAAGGGATCGCAGCACATGCCGCGAATTCCCCTCATTTGGGACGCAGCGCCCTTGATGCCGTAACGTTGATGACCACTGGCACCAACTTCCTCAACGAACATATTATTGAAAAAGCGCGCGTACACTATGCCATCACAAATAGCGGCGGGATCTCGCCCAACGTGGTCCAGGCGCAGGCAGAAGTGCTTTATCTTATCCGCGCCCCCGAAATGACCGACGTGCAGCATATTTATGATCGGGTCGCCAAAATCGCCGAAGGTGCGGCATTGATGACCGAAACCACGGTTGAATGCCGCTTCGACAAAGCCTGTTCCAGTTATCTCCCGAATCGCACCTTAGAAAATGCCATGTACCAGGCCCTATCCCATTTTGGTACCCCGGAATGGAACTCCGAAGAACTGGCTTTTGCGAAACAAATTCAGGCTACGCTCACCTCCAACGATCGGCAAAACAGTCTGAATAATATCGCCGCAACCGGTGGCGAAAACGGCAAGGTTTTTGCACTACGTCATCGTGAAACGGTACTGGCGAATGAAGTCGCTCCATATGCCGCCACCGATAACGTGCTTGCGGCATCGACTGATGTCGGCGACGTCAGTTGGAAACTGCCTGTTGCCCAGTGTTTCAGCCCCTGTTTTGCCGTCGGTACACCGCTACATACGTGGCAACTGGTTAGCCAGGGGCGAACATCTATTGCTCATAAAGGAATGCTGCTGGCGGCGAAAACTATGGCAGCAACCACAGTCAATCTCTTCCTTGATTCAGGGCTATTGCAAGAATGCCAACAAGAGCATCAGCAAGTAACGGACACGCAACCGTATCACTGCCCTATCCCGAAAAACGTGACACCGTCACCTTTAAAATAACAACAACAACGCAAACACAACAACCGAGGAATGCCCATGAGTATGTCATCCATACCGTCGTCCTCCCAATCCGGGAAGCTCTATGGCTGGGTCGAAAGAATTGGTAACAAGGTTCCCCATCCTTTTCTGCTCTTTATCTATTTGATTATCGTACTCATGGTGACGACGGCAATTTTGTCGGCCTTTGGCGTCAGTGCGAAAAACCCGACCGATGGTACGCCGGTCGTGGTGAAAAACCTGCTCAGTGTGGAAGGATTACACTGGTTTTTACCCAATGTTATTAAAAACTTTAGCGGTTTTGCTCCACTTGGTGCGATCCTGGCGCTGGTTTTAGGTGCCGGTCTGGCGGAGCGCGTCGGCTTACTGCCAGCACTAATGGTTAAAATGGCATCGCATGTTAATGCCCGCTACGCCAGTTATATGGTGCTGTTTATTGCTTTTTTCAGCCACATTTCTTCCGATGCGGCGTTAGTGATCATGCCACCGATGGGTGCGCTGATTTTTCTGGCGGTGGGCAGGCATCCAGTTGCAGGTTTACTGGCTGCCATTGCAGGCGTAGGTTGCGGCTTTACGGCTAATTTACTGATTGTCACAACCGACGTGTTGCTGTCGGGGATCAGCACGGAAGCGGCAGCTGCGTTCAATCCGCAAATGCACGTCAGTGTAATTGATAACTGGTATTTTATGGCCAGCTCCGTAGTCGTACTGACGATTGTTGGCGGCCTGATAACCGACAAAATCATCGAGCCACGGTTAGGTCAATGGCAGGGAAACAGCGATGAGAAACTGCAGACATTGACCGAAAGTCAGCGTTTTGGTTTACGCATAGCAGGTGTCGTATCGCTACTTTTTATTGCTGCGATTGCGCTGATGGTGATCCCGCAAAACGGGATATTGCGCGATCCGATTAATCACACCGTGATGCCATCACCCTTTATTAAAGGTATCGTGCCACTGATCATTCTTTTTTTCTTTGTTGTCTCGCTGGCTTATGGCATCGCTACCCGCACAATTCGACGTCAGGCGGATTTACCGCATTTAATGATTGAACCGATGAAAGAGATGGCGGGATTTATCGTGATGGTTTTTCCCCTCGCCCAATTTGTCGCCATGTTTAACTGGAGCAACATGGGGAAATTCATCGCCGTGGGGCTGACCGATATACTGGAAAGTTCAGGGCTTAGCGGCATCCCGGCGTTTGTCGGTCTGGCGTTGCTTTCCTCTTTCTTATGCATGTTTATTGCCAGCGGTTCCGCAATCTGGTCGATTCTCGCCCCCATTTTCGTACCAATGTTTATGCTACTTGGCTTTCACCCGGCATTTGCGCAAATCCTCTTTCGTATTGCCGACTCATCCGTATTGCCTTTAGCGCCGGTATCTCCTTTTGTTCCACTGTTTCTTGGATTCCTGCAACGCTACAAACCAGACGCGAAACTGGGTACTTACTATTCGTTAGTCTTGCCCTATCCACTTATCTTTTTGGTGGTATGGCTGCTGATGTTGCTGGCGTGGTATCTTGTCGGTCTGCCGATAGGTCCGGGTATTTACCCACGTTTGTCTTAAGAGAGAACGGATGCTGAGATTACTTGAAGAAAAAATTGCCACGCCACTGGGTCCACTGTGGGTGATTTGCGATGAGCAATTTCGCCTGCGGGCGGTTGAATGGGAAGAGTACAGCGAACGCATGGTGCAGCTGCTGGACATCCATTATCGCAAAGAAGGCTATGAGCGCATTTCTGCCACCAATCCAGGCGGTTTAAGCGACAAGCTTCGTGAATATTTTGCCGGTAATCTTAGCATTATTGATACGCTTCCCACTGCTACGGGGGGGACGCCATTTCAGCGCGAAGTCTGGAAAACACTACGCACTATCCCCTGCGGGCAGGTAATGCATTACGGCCAACTGGCTGAGCAATTGGGCCGTCCTGGCGCGGCGCGTGCCGTTGGTGCGGCAAACGGATCGAATCCCATCAGCATCGTCGTACCTTGCCATCGGGTTATTGGCCGAAACGGCACCATGACCGGATATGCAGGCGGAGTTCAGCGAAAAGAGTGGTTATTGCGCCATGAAGGTTATCTTTTGCTGTAAACATTAAACAATTTGTGCCAGCTTGTTCACACTTTTATGTAAAGTTACCCTTAACAACTTAAGGGTTTTCAAATAGATAGACATATATTTACATCTAATATCGGAATTCTCTGCTGTTAAGGTTTGCTTAGGGAAGGTGCGAATAAGCGGGGAAATTCTTCTCGGCTGACTCAGTCATTTCATTTCTTCATGTTTGAGCCGATTTTTTCTCCCGTAAATGCCTTGAATCAGCCTATTTAGACCGTTTCTTCGCCATTTAAGGCGTTATCCCCAGTTCACAATATAGTTAAATGCGATGTTTTTGACGGTGTTTTCCGCGTTACCAGCAGCGTTAACGGTGATGGTGTGTCCATGTGAACCAATCGCAACGGAGTGCGTATGAGCACCAATACCGACAGTATGCGCGTGTGCACCTGCGCTTGCAGCAGTGCCGGACAGTGAGTGGGTATGTGCGCCAGCAGATGATGTTGCATAGTTTTGATTATGCACAACAGACAATCTTGTTGATGCACTACCAGCACCGGAGTTAGCACTAGCCGTGTTCACGTTGGCTAGTGAGTGTGTGTGTGCTCCAGCCGAGTTTGTAGAGCCGCTCACACTGTGTGTATGTGCCCCGGTGTTATTCGTGGATTTAGTGCCGTAATCAAACGACGATGTGGTTTTCGTCCCCAAATCTGTACTGGATGCGCTGGCGCTGTGGGTATGCGATTTAATGCCGTCCTGTTCCTGAGACAATACGGCCCGACCACTGGCAGGTTTGCCCTTAATCGTCCAGCCACGCATATCAGGGATCACGCCTGACGGATAAGCGGCTGCAAGTTTCGGGTAAGCAGATTTGTCAAAAGCCTGCCCCTGCATCAGGGCATAACCAGACGGAACGGTATCTGATGGCCACGGGATTGGTGCGCCGACTGGGTAGCTTTCTGGTGGAAGATTTTTCGAGGTATAAACTTCTGCCCAGTCTTCCTCAAAACCATAACCGTCTCTTGAAGAACGGTAGAACAGACCACCATTTCTGTAATGCGCCTTCATCTGCAGGGTCCGGCAACTTCCGACTCCGGTATAGAAGTTAACCAGAATATAGCTGTCGCCAGAGCGGGTGACATTGTAAGCGCCAGATTCGGCATTCCATGGAACGCCACCATCCGCATCGGCATATGTATCCGTTGCCCTTCTGGCAAAAGCAGCCACATGCGCGGCGGTTAAAGTAATATCTTTGGAACCATCAAACTCAACACCAGAAACCCGTCTTGGCGTTTGCAGCTTTGTTGCTGTTAATGCATTACCGTTCAGACTTGCGGACAGTTTGGTTCCAATAACCAGTTCGCCGGTTGCGTTATCAATAGCAAACGGTCTTAATGTATTCCAGCCACCATAAACATCACCTTGATTGGTAAGCAGCAGGTAAGTTTTAGCGCCATCATTACGCCATAATGCACCATACTCCCCACCTATCATTCGAATCTGATTACCACCACGCGCTACAATTTCGTCTGTGGCAAAAAGTTTTTTGCACGACAAGTTATCGTTAACGATTAACGAATGAGACTCATAAAAACCACGCCCACTCTTAAAATCAAGGATAACGTCCGCCGCGATACATTCAGTCGCCGGATTTGTTGCCCCAAACTTATAGGTCGTATCATTAACAACGAGATCAGCACCAGGTGCGGATATTGACAGGCCATCTTCAATAAACGCAAAAACAGGGAAAGCAGCGCCATCAACATAGAACACAGAGCGCAAATCATCGCCCTTATTACTCATCATTATTGAGTGAATGGCTCGTTCATTGTTTTGATATTGCCAGAACATGCCATAAGCATAACGCCCCCTGTCAGTCCAGCCACCAGGCATAACAAATCCGTTAAACTCGCAGTTATTCATCGGATCGCCTGCGGTTCGCGTTGCCGTGGTGATAATGACTCTTGATGCCAGTTCGCTTACTGAGCCAGCAGAACGCATAACAACAACAGGGTAATATTTTCCAGATGTTGCACCTGCAGGAGCGTTAACCCGCACATAACGCATACCACGCTTATCAGCAAAGTCTGTTTTACTGACCGCGTTAATGTTGTTCAGGAAGCATCCCTTATCGGGTATATCAGCGCCGTTCTGGTCTTTCTGCAGACGTTTCTCTGCATTGTCATAGGCTGATTTTACTGCCTTTGGCGTTGCCGCCAGCGTTTCAGACGTACTGTTGGTCGCACTGCTGAGCTGTACTATCCCCTTTTTCGTCGTACTTGCATCCTCAAGCGCCACGGCGGATGCAATATCCTCTGCCCGTTTAGCTGCTGTCTCGGCGCGCGTTGCCGCGGATTCCGCCGTACTTTTGCTCTGAGCTGCCGCCGTCGCACTGCCAGCAGCCTCTGTCGCCTTCGTGGATGCCGTCGTGGCGCTGCTCTTCGCTGCTGACGCTTGTCTGGTCGCCTCATCTTTTGAAGCAGACGCCGATGATGCCGATGACGCCGCCGAACTGGCTGACGATGCGGCAGCCGTTTTTGAGGATTCTGCGCTTGTTTCCGACGCTTTCGCGTTCGTTTCGGATGTCTTCGCTGCGGAAGCAGACCTCGCTGCTGCGCTGGCCTGTTCAGTGGCTTCGCCAGCCTTCGTTGTGGCTGTTGAAGCAGACGATGCGGCGCTTTCTGCCGATTTTCCGGCGGCGGTGGCACTGGCTGAGGCCTGCCCGGCACTTGTTGACGCTGCACTGGCAGACGACGCAGCCGCTGTTTTTGAGCCTGCCGCAGCCGAGGCGCTCTGTCCCGCTGCCGTTTCAGAAGACCTGGCGTTCGTCTCGGACGTTTTTGCCGCCTTCGCGGAATTTCCTGCCGCCGTTGCCGAGGAAGCTGCACTACTGGCGCTTGATGATGCGTTCGTTTCTGATGATTTTGCCGCTTCTTTTGAGGCCGCCGCATCCCGGGCCGAGGTCGCAGCTTCTGATGCCTTCGTGGTCGCGGTGGATGCAGATGTGGCTGCTGATTGTAGTGACGCTGAAGCATTCGTTTCTGACGTTTTCGCCGCACCGGCACTGGTGGCCGCCGCGCTTTTTGAGGACTCTGCAGCGGCAGCACTTTTTGATGCTTCAGTGGCCTTTGTTGATGCCGTTCCTGCGCTGGAAGACGCTGACTGAGCCGACGACGCGGCCTGTCCGGCTGACGTGCTGGCTGCGCGTGCTGAGTCCGCAGCATCAGCCGCATGGGTTGCCGCCTCACGGGCTGATGTGCTGGCATCACTGGCTGT
+>5_2#NODE_15_length_39993_cov_62.9495_ID_29
+TCTTGATTATTGGCGATAAAGTCCCAAAAAGTATCGTGTGCTGTTTGTCCTTGGGGAATCTCATTATGTGGCTCTGGTTTAAGAGCATGAATAAGATCCGGAAATTTAATACCATCTTGAATGAAGAAAATCGGAATGTTATTACCCACTAAATCGAAATTTCCTTCCTCTGTATAAAACTTAACAGCGAATCCTCGTACATCTCGGTTCGTTTCATTTGCACCTTTTGATCCAGCAACTTCAGAAAAACGAATAAAAATAGGTGTCTTTTTAGATGGGTCTTGTAAAAAATGAGCCATTGTTAAGTCTTCTAAAGAATCATATAGCTCAAAAACACCATGTGCTCCGTAACCGCGGGCATGAACGACTCTTTCAGGAATTCGTTCACGGTCAAAATGAGCGAGTTTTTCTCGCATCAGGAAATCTTCTAAAAGTGTAGGACCACGATCGCCGGCGGTTAAAGAGTTTTCATCATTTGAAATTTTGACACCCGTATTCGTTGTCATCTCTTTTCCTTCATTGTTTTTCGTAAAGGATTGTAACTGTTCTATCTTCTTATTTTCACGACCGTCCATATAAAGCACCTCCCATATTATACGTATTATTGTTCATGGTTTTTATGCTTACATATGGTATGGGGAAGTATATTATCTATGGATTGATTTTCCTCATTTGTTCAATTTATCTTTGTTTGTCTATGAAAATCATTTATTATAATAAATGGTATTCTTTTGAAGGGGTGTTGAAGTGGAAGAGAGTTTTCTATCAGCTAAAGAAGAAAAGAAAAACGCTAAGATTTTCTTATGGGTAATACATGTTATTTTAATTGTATACGAGGTTGCATACGCGATTATATTAGAAGATACAATGCCTTTAGCAAATTGGCATAAAGGGATATGGAAGCTTGCATATATTATGGCTATATTAGGTATTAGTGTTTACTTATTTGAGAGAGAAAAAGCATATTTAGTTAAATATACATATTTATTTGCATACATGATCGCAGAGACTTTTAATATTGGATGGTATGCTTTTCATAATACAATAGCATTTGATGAAGGGAATGTAATTGAATATATTTTCATTTTCTTCGTACCGATCTTTTTGAGTAAAAGATATTTATTTGTCTTAGCGCCATTCCTTATAGGGAAATATATGATATACCTATTTGTATTTGGAGAACTTAACCTGTTTATGTCTCTTGTTATAAATATGGTGTTACTTTTCGTGTCATTTATTATTTTAAATCGATTTTTACAATATCTTTCAGCAGTAAAGGGACGTATTGCAGAGGCAAGTCATTCACAAAAATTGGCGGTTATCGGAAAAATGGCAGCGACAGTCGGACATGAAATTAAAAACCCACTTGCTTCATTAAAAGGGTTTACGCAATTACAAAAAGAGAAACACGAAAAAGATGCAACATATGAACAAATGATTCTCGAAATCGAAAATATGAATAATATGATTAGTGAATTAATGGAGGTTGCTGCATGTAAACCTTCTGTTTATGAAAAACACATTGTAAGTGATGTTTTAGTACAAGCGGTAGAAAACATGCGCGGAAAAATGAACGAGTTAAATATAAATTGTACCTTTAATGAAGAGCAAAATAGAAGCGAAATTGAATGTGATAAACGCAAATTAAAAGGAGTATTTTTGTATGTTATTAAAAATGCTTTAGAGGCAATGGAACATGGCGGAACATTAAAAATACAAGTTGAAAATAAAAAAAGAGATTATGTAATAGTAAGTATAGTAGATAGTGGTTTTGGGATAAAAAAGGATAATTTAGGACGAGTTAAGGATGCTTTTTATACAACGAAGCAAGATAGAATTGGATTAGGTCTTACGGTAGCAGAGCGAATTGTGACAGAGCACCTTGGAGAATTACACATTTCTAGTGAAGTAAAGAAAGGAACGAGAGTAGAAATACTGCTCCCGAAAAAATGTGAGCGCAATGTGACACAAGATTAAGAGGTGTTGTTAAAGGAGCTATCATATGGAAAAAGGAAATATATTTGAAAAAGAAGAGATAAAGGCATTAATAATATTTTTAAGCTTATTCTTCGTTATATTTTTTGCGTATGATTTTGCTGAAAAAGCTATTGTCCTTTTATCAGATAAAAATCAAAAACTAGCAGATGCTTTTGGAGAAGGATTAGGTTTATGGCTATATAGTTTTATGGTTGGATTATTCTTTATAGGACTTTATTTTATGAAATGGAAAAAGCCGTATATTGTGAAGTATATTATTTTAATTGGCTATAATATATTGGATTTTATTAATAACTTCATTATTTATTACGGAAGTGATGCGGAATTTGATGGCGGGAATATAGTAGAAGGATTCTTTATTTTATTTGCACCAATATTTGTGAATAAGAGGTACTTTTGGTTAGTTGCGGGAACTATTGTTGGAAAATATGCACTTATGGGATTCGTTGTTCAATCCTTTATTGTTCTTATCCCAATAGCATTATATAGCGTGTTTGTTATTATATGTTGGATTATATTTTTAAGATTCCAATCTTACGTTCGTACACTTGAAATGATGGATAAAGAAATACGAAATGTAGAGAAATTAGCAATGGTTGGAAAAATGGCGACAGTAATTGGCGATAAGATTAGAAGACCGTTAGAAAAATTGAAAAAACTTGTGAATAAGCAAGCGAAAAAATATCCAGAAGATAAAATTTATAGTGAAATTATGAGACAGGAAGTAGAGCGAATTCATACAATTGCTACAGAACTAAATGGGTTTGAGAAATCTAAATCGGTAGAATCCGAAACGTATAATATTAAAGAAATCATCTCTTATGTTATCAGGGTTATGGAAAAGCCAGCTTTAGAACAAGGAATAAAAATGCATGCTATTTATAGTAAAGATATACCATCAATTACATGTGAGGAAAAACGATTGAAACAAGTATTTTTTAATTTAATAAAAAATGCGATTGAAGCAATGTCAGTTGGCGGAACTATTACTGTAAAAGTTATAGTGGAAGATGTGATCATTGTTCAAATTATAGATGAGGGATGCGGCATTCCGAAAGATAAAATTCCGAAGCTAAATGAAGCTTTTTACACAACGAAAGAAACTGGAACAGGCTTAGGATTAGTAGTTACGGAAAAAATTATTAAAGATCACCACGGTAAATTGAACTTTGAAAGTGAAGTTGGAGTTGGAACGACTGTTGAGATTATGTTGCCGATTTAATTATAGTGGGATATTTTAAAAAGGGGAAATCACTTTCTTTAGAGTGATTTCCCTTTTCAGTGTGGAAGGAAGTACGGAATTTTAATAAACGGGATGTTTACAACATTGACAAACTGTACAAATTCACAATCCAAAATATGGGTGTTTTAAAGCGAGAGTATATAATAAATTTGTCTGTTATTTGTTTTAATTTATTTGCAATTTTTTTGGCCTCGGCATCGAGGTCCTTTTTGTAAATGAATGATTTGTAAGTGTGGATTATATATCAGTGATTAGAAAAATAGAATATACAGAACTTGCCGTAATCCCGGGGGTAATATAAAGAGATATCGCATCCCCCCTCGAAAACAGGTTTCCGGTTGTAATACTAGTCCAAGTTACAGTGGCAGGTCCAGGTGCTGGAGTAGGGTTATACACTTGAGGTTGTCTAGAGCCAATATCCGTAGGTTTAATTGAAAATGTCATAGTTCCCGTAATTTTATCTGTAGTAGTTAAAGTAATAGTAGATAGGATGTAACTAGAGGTAGGGGCAGAGAGGTTTGTTGGGACATTCCTGCAAATATCAATCGTATAAACAGCAGCGGGTAAGTTATTAATATTTATAGATGTAGCAAAACCAACTATATTTCCAGCTCCAGCAGTTACATACGGAATAACGTTAGAATCAATTCCTGGAGAACCTGCTATACGTTGAAACCCAGCATTCGTCCCTTGAAAAACAATACTTTTCGCTGTTGAACTACCAGCAGGTCCAGTAGTCCCGGTAGAACCAGTGGCACCAATAGTTCCGGTAGCTCCGGTAGAACCAGTGACTCCAGTAGAACCAGTAGCTCCGGTAGAACCAGTGACTCCAGTAGAACCAGAAGCTCCGGTAGAACCAGTGACTCCAATAGTCCCGGTAGCTCCGGTAGAACCAGTGACTCCGGTAGAACCAGTAGAACCAGTAGTTCCGGTAGAACCAGTAGAACCACCTTCTACCAATACGATATAATCTTGAGACACATTCGGAAATCCTTGAGGTGCATCTTTTTTTACAACATAGCCGCTACTCGTGTAAGTGACAACTTGTCCCGTTTTATAGTTAGGAGCGGCTGCTAGACTAAAAGCGGTAGTACTTTGCAAACCGGCCCCGGCATTGCCAGTAGGTCCAGTAGCACCAGTGGGTCCAGTAGCACCGATAGAACCGCTGTTGCGTCTACCGTCACAACTAAAGCAATTGCGTTGGTACATATATTATCTCCTTTCTATATTTTTGAAAATCTAGTTTTAAAAGTAGAACTACTATATATATATTGTAGATTCTATATTTTTGTGTGGTCGATCGTATTGTGTATATAGATTTTAAAAATAGGGGAGGTGTTATTAGTTTTATAACCACCAGGTCTCCTGCGGAATCAAAGTAACATCTACATCAAAATTCTCTTTAAACCAATCATACATCAATGTCTCTTTCACTAAATATTCAGAGGCAGAGTGTGACAAACCGATGAGTGACATATTTGTTTCTTTCGCATAATCCATAATGAGTGAGTATTTATGCCTACCATAATCATTGTCGATATGGCAATGGATTTCTCCTGTAATAAATGATTAAGTTATTGTTCTATTTCTTTTAAGGCTGGCATGTTTGGTAATCCTCCTTAAGATAGTTCTTACTTTGTTAGTTGTTTTTGTTTTTTTATGGAAAAATAAGAAGCGGATAGGAAACAAATAAAACCTAGAATCCAGCCAATAGAAGGAGAATAGGGAAGTATATGTTGTAATACCATTCCGCTAGAAATAAAAAAGCTACCTAATAGACCTAAGAAAATGAGATATCGCTGTAGTTTGAACATCAGTGATACAACCTCCTTTATCACGCATTAACTGCCCGTAACCTGATTGGCGAGGGCTAATAATCAGAGGGGGATGGATACCTCCCTGATTAAAGTTTCACTTTATCACATATATTTCAAAGTAGTCTTAATTTTCTGCATATAAGATTCGAGAAAAATGGTGGTACAATATATAAATGATACGAGAAGAGAGGATGTAGGTTAACACATGTACGTTACTGTAACAGAGGCAGCATATAAAAAGATTATGGATACGATTCCAAGTGAAACGAAATATATAAAGTTATTTTATGATAATGAAGGTTGCGGTTGTGTTATGAGCGGGATTATCGATTTAGTAGCCGTTTCAGAGAAAGATGAGCGCGATGTAGATATCGAATCAAGCGTACTAAACTTTATTGCAGATCGCACAAAGCTTGTATTTATGGATGATAAATTAACAGTTGATTGGCATGAAGTTGGAGGGACTTTCCAGCTGAAGAGCCCAAGCCAGTTTTATAATCCGAATATGAAGTTACATGTTCGAGTATAATGAAGAGAGAAGGAGTATATAATATGCTCCTTTTTCTTATGGATTTTTTCACATAATGAAATGTACATATAGTTGAATTTTCTGTATAATTCTCTTTGCGAAGGGAGTTGCGCATGAAAAGATGGGGAATTGAGTTATTAATTTTAAGTGTCGTTATTATTTGGGGGATTAACTATACGATTGCGAAATATGGACTTTTAGAATTTACAGCAATTGAGTTTACTGCAGTTCGAATGATGACAGCAGCACCACTACTGTTATTACTTACGTTCTTTATCGAAAAGTCACTTTATATGGAGCGAAAAGATATACCAAGATTAATCATCGTTAGCGTTGTAGGTATTGTACTGTATCAAACGTTATTTATGGAAACTGTAAAATACACATCCGCTACAAATGCTTCTTTACTCATATCTATTTCACCTATTTTTACAACTGTATTTGCGATTTTCTTGAAACAAGAAAAATTTTCTTCTCGAAAGTTAGTTGGTTCCATGATTGCCTTTATTGGTGCTACATTAGTTTTAGTAGCGGGGCATTCACTCGCTAGTTCTTTCTACGGAAATGGGATTGGACTTATTACATCAATATGTTGGGGACTTTACCCCGTTTTAGCAGGGCCGCTTATTAAAAAATACTCAGCATTACGTGTTACTGCATGGTCGACATTAGTTGGAGCGATTCCGCTCTTATTGTTAAGTGGCCCACATGTATTTGTCATGCCATTTCACATTACACACGGAATGACACTATTTGCTTTACTATATTCTGTTTTCTTTGTAACAGTATTCGGTTTAGTCATGTGGTATGTTGGTGTTCAAAAAATTGGTGCGTCACATACGATGGTATATATGTATATTACGCCGCTTGTAGCTGTTTTATTTGCAGCTGTATGGGCAAATGAATATGTATCGTTTCAACAAATAATCGGTGGAATCATCATTTTCTTCGGTCTATGGTTTGTGAAATCAGAGAAAGTAGAAGCTAATTCTATCGTGCAAGAACCTATATCAAAATAGGAAAACAGATCACCTATGATCTGCTTTCCTATTTTTTTATTTTTGGTAAAAATACGAGGAATAAAATGGCAGTAATAAGTGGGATTAAATTAAGAAAAGGAATGCGGAAGAGTGTAATAAGAATAATACCTGGAAGAAGAACACCGAGGACAGCATAGAAAATACTATGTTTTTTCGTGTACCAATACAAGGAAAGTCCAATAAGTGCAGGAACAATGAGATGAATGAGAGCCATTAAAAAATAAATCATTAGACGCCCCCTTTATTTATGTGCTTATTACATCATATCCGTATGTTCATAGATTGATATCAATTTTTTCATAATTGGACGGAAATGTTTTGAAAAACGTCACATTTATGAGGGATTCTATATTAAAAATCTTGTATAATATTATTTCCTAAAAGCATTTTAACAACATAAACATACCGTTTATGTTGTTTTTAATTTGAATGAAATAGATTTTAAGTAGTATGGACTCGAAAGAAATGAGTTATACAGCTTTTGTTGGATAAATAGAAAAAACATTGAAGGGGAGTACAGCATGATTAGTTTGTCATTAAAATCGTTTAAAGTTCAATCATATTATCTACTAGGTATTCTGTTATTAGGCTGGATGTTAACACCGTTTTCAGCACATTTTCTAGGTGCAGGAATTGGACTTATTGTAAGCATGTATTGTGTTTGGATTTTAGGAAGGCGTATCGAAAAGCTTGGAGATAGTATAGTAAAGAAGACGAAAGCACCGACGCTTGGTATGTTTAATCGCTTTGCAGCTGCAATTTTGGGTGCTATTATCATGTACGAAATTGAGCATCATATGGTAATGTGGGCATTTGCAATAGGTATTCTGGGTGGTTATTTCTTAATCGTTATTAATTTAGGGTATTATAGTATGAAGGATGAGGAAGAATTAACGAAGGGCTGAAAAAGATAAAAAGATGAAAAGCCTCTTTTTAGATGGGATAGAGGATCCAGCGGTGGATAGAAGCCGTTAGGGCCTTTTTTAGCCACATGCGGTGCGAAACCAGAGCGAGGTAGTGAGCAGGAATATAATTTATATGTTCGAAGCCGTAATTTGTATATATGAAAATCTGGTTATTTAAATTGAAAATTGGCTTACTCTGGAATAAGGGATCCGGCGATGGATAGTACAACAGGAAGCGTAACTTTGTATAAAATATAGGTTTCCGCTTCCAATAAGTTAATATGAAATCACTTAGTAGTATGACTCTTAGGTTCTTTAAAAAAGTTGGATACAATACAACAAACTATTCCGGTAATTAGAATAATGTATTTTATCGTTTCACTTGTATGCTCAAATAAATTAACGTTAAGCATTACAAGTCCCCAAAACATTTGAATCGCTCCATAACTGAATAAAATTTTTTCTGTACGAGAAAAATTTTTCATGGGCCTCACCCTTTCCTTTATATGTAAAATATATCATAGGAAACTACAAACGAATGATTATAAAATGAATTTTCTGTAAATTTATAGGTATTGGTATGCAATAGATGAAGAGATTAAAGTTTCACTTTATATAAGATATAGAAAGAAGCTTACGTTTTTAACGTAAGCTTCTTTTTTATGTAAGTGTGTGTAACCGTTAAGCCGCATTGGGTTTTGTCGGTGAGTACGCGGAACTTTACGGTTACACGACACTTATTCATATGAGTAAAAGGGTTATTCCAACAGAAAATTTGTAATTAAGCGATTGGACCGCCTAAGTTAATAATAGCTTCAGAAACGCTATCGAATTTTTTGAAGTTTTCTTTAAATTCGTTTGCAAGCTCAATTGCTTTCACTTTGTAAGCATCTTTATCAGCCCAAGTTTGTTCAGGCATTAATACTTCATCAGGTACACCTGGAACATGACGAGGTACTTCAAGGCCAAAGATGTCGTGTTTTGCAGTTTCAGCTTTAGCAAGTTCACCGCTTAGTGCTGCTTGAATCATTGCACGAGTGTAACCTAAGTTCATACGTTTACCAACGCCGTATTCGCCACCAGTCCAGCCAGTGTTTACTAAGAATACTTTCGCATCATGTTTCTCGATTTTTTCACCAAGCATTTCAGCATAACGAGATGCATCAAGCGGTAAGAACGGTGAACCGAAGCAAGTAGAGAATGTAGCTTGCGGAGATGTAACACCGCGCTCTGTTCCTGCTAGCTTACTAGTGTAACCGCTTAAGAAATGGTACATAGCTTGCTCTTTTGATAACTTACTGATTGGAGGCAATACGCCAGATGCATCAGCAGTTAAGAAAATAATTGTATTTGGATGTCCTGCAACACTTGGCAGTACGATATTGTCAATCGCATGCATAGGGTATGCAGCACGTGTATTTTCTGTTAAAGTAGTATCGTTATAGTCAGCGATGCGTGTTTGACCATCAATGACAACGTTTTCTAAAACTGAACCAAATTTGATTGCATCGAAGATTTGTGGTTCTTTCTCATGAGAAAGGTTTACACATTTTGCATAGCAACCGCCTTCAATATTGAATACGCCGTTATCAGACCAACCGTGCTCATCGTCACCGATTAATTTACGGTTTGGATCAGCAGATAATGTTGTTTTGCCTGTTCCAGATAAACCGAAGAATAGTGCTACGTCGCCTTCTTCGCCTACGTTTGAAGAGCAGTGCATAGAAAGAATGTCTTGTTCAGGTAGTAAGAAGTTCATAATAGAGAAGATTGATTTTTTCATTTCTCCAGCGTATTCTGTACCACCGATTAGTACGATACGTTTTTCGAATGAAACCATAATGAATGCTTCAGAATTTGTACCGTCAATTGCTGGATCTGCTTTGAAGTTTGGTGCAGAAACAATTGTGAACTCTGATTCGTGAGTTGCTAATTCTTCTTCATTTGGACGAATAAATAATTGATGTACGAACAAATTATGCCATGCATATTCGTTAACAACTTGAATTGGTAGGCGATAGTTGCGATCAGCGCCAGCAAATCCTTTGAAGATGAATAACTCTTCTTTTTCTTTTAAGTATTCTAAAACTTTTATATATAATTTATTAAAATGTTCTTCAGAGATCGGTTGGTTCACGGCTCCCCAAGCAATTTTGTCAGCAACCGATGCTTCCTTCACAATAAATTTATCCTTAGGAGAACGTCCTGTGTATTTTCCTGTTGAAGCAGAAACGGCACCAGTAGAAGTTAATTTCCCTTCGTTTCGCATTAATACTTTTTCCACTAATTGCGGAACACTTAATTGAATCTGTGCATTGCTTCCGTTCAATAATTCATGTAAACCAATTTGGACATTCACAGTACTCATATTTATATACCATCCTTTTCATTTAATGAAATATTTCTCGTAATCCCCATCAATAGTATAACACAATTATATAAATAATGTATACTATTTATTTATTTTTGTTTGTGTGAATGTATCATTTCCCTATTAATATTTCATTCTATGGGTATTGAGAAAAACTTTCAGGAAAATGTGAATATTAATTGACAAATGAATATCATTTCTTTAGTATAGGTTGGGACGGATACTCTCTTATCCCGAGCTGGCGGAGGGACAGGCCCGATGAAGCCCAGCAACCTCATTTGTAGTGGTAAATACAGGTGAATAGGTGCTAAAACCTGTGCGAGGCTAACGGTCTCGAACGATAAGAGCAAAGGGCAAAAAGCAGTATGCAAGTAGCAAATTAAACCTTTCCTCTATGTTAAGTAGGAAAGGTTTTTCTGTATGCTTGTGTGGGAGAATAAATGTATGTCGCAGTTTGTGGCAAATTAAGGATGAGTTCCGTACAATATATACAATTACTGTAGGGAGGTTTACCACATGACAAAAAAACGTCATCTGTTCACATCTGAGTCTGTAACTGAAGGACATCCAGATAAAATTTGTGACCAAATTTCTGATTCAATTTTAGATGCGATCTTAGCAAAGGACGCAAATGCACGTGTAGCTTGTGAAACAACTGTAACAACTGGTTTAGTATTGGTAGCGGGGGAAATTACGACTTCTACTTACGTAGATATTCCAAAAATCGTTCGTGAAACAATTCAAGGCATTGGTTACACACGCGCAAAATACGGATTCGATGCAGAAACTTGTGCAGTTTTAACATCTATCGATGAGCAATCTGCTGACATCGCTATGGGTGTTGACCAAGCACTAGAAGCACGCGAAGGTCAAATGACTGACGCTGAGATTGAGGCAATTGGTGCGGGAGACCAAGGTTTAATGTTTGGCTTCGCATGTAATGAAACACAAGAATTAATGCCACTTCCAATCTCGCTTGCTCACAAATTAGCTCGTCGTTTAACTGAAGTACGTAAAGATGACACATTATCATACTTACGTCCGGATGGAAAAACGCAAGTTACAGTTGAGTATGATGAAAATGGTAAACCTGTACGTGTGGATACAATTGTAATTTCTACACAACATCATCCAGATGTTACGTGGGAAGAAATCGATCGCGATTTAAAAGAGCACGTAATTAAAGCTGTAGTTCCAGCAGAATTAATGGATGGAGAAACGAAATTCTTCATTAACCCAACTGGCCGCTTCGTAATTGGTGGACCACAAGGTGATGCTGGTTTAACAGGACGTAAAATCATCGTTGATACTTACGGTGGATACGCTCGCCATGGCGGTGGTGCATTCTCTGGTAAAGATGCAACGAAAGTTGACCGTTCTGCAGCATATGCAGCTCGTTATGTTGCGAAAAACATCGTAGCAGCTGGTCTTGCTGACAAAGCAGAAGTACAACTTGCATACGCAATTGGCGTAGCACAACCAGTATCAATTTCAGTTGATACATTAGGCACTGGTAAAGTATCTGAAGACGTATTAGTAGAACTAGTTCGTAACAACTTCGATCTTCGCCCAGCTGGTATTATTAAAATGCTAGACTTACGTCGCCCAATTTACAAACAAACAGCAGCTTACGGCCACTTCGGACGTACTGATGTAGATCTTACATGGGAACGTACAGACAAAGCAGCTACTTTAAAAGAGCAAGCTGGTCTATAATATATGAAAAAAAGCTTTGCGCTGTGTGCGCAAAGCTTTTTTTATTTGGTTTTATCCCGCATTAACTGCCCGTAAAAGCCCGATTGGTTCAACTAATAATCAGTGGGGAAGAACAAAATCCCCACTGATTAAAGTTTCACTTTATTTACTACTTGAATGCAAGAACTACAATAAACTTCCCCGTCTAGCTCAATATACTTCTTCATATTTGTCATACCACTTGCCGGAAATGGCATATGAATCCACGCTTTTTCATACGTTTGTATTTCCTTTTCACATGATTTACAAAGGATTGGTTTCTTACGGAACATAGACGGTCACCCTTTCAGTTGGCGTGCTTTTCCTGCGCAAAAAGCACTGCTCAGTAAAAATAGCGTTGCGAATATAATACTCACTAATGTAGCGTATGGAATCGCGCCTTTTAAGGAAAAGCCGACAGTGATGGAAGCAACAAATAAGAGAATGAATGTTGTTGTTAATTTTTTGTAAAGTTCCATAGTGAGTGAACCTCCAAATTATTTTGTAATTTAAAATGAAATCTACTATGTAGAAAATATAAGGGGATTTAAAGAGTAGCTAATGGTGTGTAGTCCAGGCGTATAAGAAAGTATATTTTCCTTTTTGTGGTCGTATATACTTATATTGTATCACGGTGCATCATTGGCTTCATACATAATTGTGTAAAGATATGTATGATAAAATGAAGAAAAGTCTTTAGGAAAGGAAAGATGAAAAATGAGCGTAACTGAACATAAAAAACAAGCTCCAAAAGAAGTGCGCTGCAAAATCGTGACGATTTCCGATACACGTACGGAAGAGACGGATAAGAGCGGACAACTATTACATGAATTATTAAAAGAAGCAGGACATAAAGTGACCTCTTATGAAATTGTGAAAGATGATAAAGAGAGTATTCAGCAGGCTGTGTTAGCTGGTTATCATAGGGAAGATGTTGATGTCGTGCTAACGAATGGTGGAACTGGTATTACGAAACGTGATGTAACGATTGAGGCAGTATCAGTGTTATTAGATAAAGAAATTGTTGGATTTGGTGAGTTGTTCCGTATGATCAGTTATTTAGAAGATATCGGAAGTAGCGCAATGTTAAGTAGAGCGATCGGTGGTACAATCGGGCGTAAAGTTGTCTTTTCGATGCCAGGGTCTAGCGGAGCGGTTCGTCTTGCGATGAACAAGTTAATTTTACCGGAATTAGGTCATATTACATTTGAGTTGCATCGTCAATGAGTAAGTGTGCTGGAATTGTATTAGCAGGAGGTATGTCGAGCCGATTCGGTGAGCCGAAAGCGTTAGTAGGCTGGAAAGAAAGTACTTTTATTGAGCATATTGTGAAAGTAATGGAAAGCGCTGTGCAAGAAATTGTAGTCATTAGTCATACTGATATAAAAGAGAGAGTAGAGCAATTAGTACAAGTTCCAGTTATAGAAGATATGTCGCACTATAAAGGAAATGGGCCACTTGCTGGAATAGTGTCAGGAATGGAATACATAGATTCAGATTGGTATATTATCATGCCTTGTGATGCACCGAACGTTTCAAATGAATGGATTACCATTTTATTAGAGCAAACGAGCGATGAATATGATGCTGTTGTCCCTATTATTAATGGAAGAAAACAACCGTTACTTGCAGCGTATAATAACCGCGTGAAAGAAAAGATTTATGCTTTGCTTCAAGAAGAAAAAAGAAGTATGGGCCAGCTTTTATCACAATGTAATGTGAAATATATTGCTGGTGAAGATGTACAAGCGAATGTAGATTGGTTTATAAATGTGAATACGAAAGAAGAATATGTGCAGGCTCAAAAAGACCTTTCAAATGAATGAAAGGTTTTTTGGTATACAGAAATTGGAGAACAATTGCTGTATAAAGGTATGTGAGTAAGTTGATTTTAAGGGGATTTCGTGAACTACCCGCCACTTAACGTCCTAAAGGAGTGTTTGAAGTGAGGGCTTCTCGGTTAATCATTACTTCTGATAGCTAACGAATTCGTCCTAAGACAGCCGAGCTAACTCCCTTGTTCCAAAGGTTATTTTATTACAATTTATGCTGACGCTAAAAGACGTATTGCTTCATTTTTGATATTGATGGCTGAGTTATAATCTCTATCGAGATTTACACCGCATATACAAGAATAGATTCGTTCAGACAATGTCAGACTTTTCACATTTCCACAGCTACTACATGTTTTTGTTGATGGAAACCATTTGTCTATTTTCACAAGTTGTTTTCCTTGTTCGTTTAGTTTATAAGTTAAGAAAGAAGTGAACATACCCCACCCATTATCAGCGACACTTTTTCCAAAATGAAGTGCTTGCGATATTCCTTTCATGTTTAGATCTTCAATAGCTACAACATCAAAATTGGCAGCTAACTTTTTAGACTCATGATGAAGAAAATTCTTACGTTGGTTAGCTACTTTCTCATGTAACGTAGCTACACGAATACGTTGTTTATTCCAACGTTCAGAACCTTTATTGCGTCTTGATAATACTCGTTGCGCCTTTGTTAATCGGTCTAACATGTTACGATAGAACTTAGGATAATTGGCTTTCTCATCCTCAGAACTGACGTATAATCCATCCATTGCAAAGTCTAATCCAACAACTGTTTCTACTTCTTTTTGTACAATCTCTTTTTCGTATTCAGTCAAGATTGACACATAGTATTTACCAGTAGGTGTCATAGAAATCGTACAAGACTTGATCATATAATCTTGTGGTATCTCTCTATGTTTTTTGATACGTACCATTTTCAGTTTTGGCAATTTGATATGACCATTAAGCAACAGAATATTACCGTTTACTACATTCGTTGTATAAGACTTTCTGTCCTTTTTACTTTTGAATGTTGGGAAGTTATTTTGACCACTAAAGAAATTCTTATATGCAGTTTGCAAGTGTAGTTGAGCATTTGCAAAAGCTAATGAATCAACTTCTTTTAACCACTCAAATTCTGCTTTATATTTCGCAGGGGTTGGAGGCTTTTGTTTCTTTAGTTGTTCCTTATCATCTTTGTATTTTTCGTACGCTTCTTTTCGCTCAGCTAACATTCTATTGTACACGAAACGTACACAACCGAAGGTTTTACGTATAAGATTTGCTTGTTCTTCTGTTGGATACAACCGGAATTTATATGCTTTATTCTGCTTTGTCATATCATTTCACCTCACTTTTTACCTTGATTTTCAATATGTTTCTTTACTACGTCTATTGGCGAACTACCAGTAGTTAGTAAGCAAAAACTTCTTGACCAAAACATTTCTTTCTAAAGTTTTTTTCACTTGTGGAAAGTCTTTCTTGATTAGTTGAGAACTTGCACTTTTATAAGCATTAATAAATTTTGTCATTTCTTTTTAAGCGAGTAATTCTGATGCGGTGTGCTGAAGGACTGTTTCATATTGGTCAAGTAAGCCACGAAAGATTCCATCCCAGCTTTTTGATTGGGCATAAGACGAAGCAGCTATACCCATTTGCATAAGCTGCTCTTCATTTTGTAATAAAGAATGGATGGATGATAGAAATGAATCTGCATGTTTGGGTGGGCAAAGAACTCCTGTTTTTCCATCTGTAATAATATTTTTAACTCCGCCACTATTTGCACCAATGACAGGTGTACCGCATGCAAATGATTCAAGTACGACATTTCCGAACGTTTCAGTAGCTGATGGAAATACCATCATATGAGAACAAGCATATGCTTCAGCTAAATCCGTACCTTGTAAATATCCAGTAAAAGTGACATTTGTTTTCGGAACAGCTTCACGCAAATTTGTTGCTAGAGGCCCGTCTCCAGCGATGAGCCAATGAATATCGTCACGTTCTTTGTTTGTCGTTTGAATAAGTGTTTGAAGAGTATCGATATCTTTTTCAGGAGCAAGGCGTCCGACGTAGGAAAGAATATGTTTCGCTGTAATATTATATTTTTTTCGGAATAGGTCTTTATTGTAAGTTGGATGAAAGAGAGTACAATCTACACCACGTCCCCAAATATAGAGCTGTTGAAATCCTTTTTTCTTTAATTGATGTAATGTTTCAGGAGAAGGAACAAAGTTTTTTTGCATATGACTATGAAACCAGCTTAAATAGTTCCATAGCATATTGGAGAGAAATTCGATTTTGTAATAGCGTAAATAGGCGTCAAAATCAGTATGATAAGAACCGACAACTGGGATATTTAACTTTTTGGCATAATATAACCCACAAAGTCCCATATTGAAAGGCGTAGCGATGTGAATGATATCAGGTTTAAAGGCAAGAAGTTCCCGCTTAATGCGCGGAGTAGGAAAGGCAAAGCGACATTCTGGATATAATATTGTTAACGGGATACTTCTCATTTTGTTCACATTCGCTACGAAATTATCTTCTGCCGTATGCTGAGGGGCGAAAACAGAATAGGCGATATTTTCTTTTTGAAAATATTTAGTTAAACGTTCCAAAGTTTTCGCCACACCGTTGACTTGTGGTGTAAATGTATCGGTAAATATGGCGACTCTCATCATATCGCTCCTTTACATGAGTGGAATGAGTTGATAAAAAGAGATGATGCCAGAGCAAGTGCCAAGGCACATGCCTACAAATACATCTGACGGATAATGAAGCCCTAAATAAATACGGGAAATACCGACGCATAATGCTAACGGTAATAGAAAAGCAAGCAAGTTTGGATTATAGCAAATAAATGGAATGAGGACAGAGAAAACAGCCGTTGTATGTCCGGATGGAAAAGAATGATCTTTTAATGGATGAACTGGATATTTCGCATCCTGAATTGTTAAATAAGGGCGTTTTCGTGGATACCATCTTTTTAATATTTGCACAGGAATATGGCTAATTGTTAAAGAAATAGCAGTTGCAATTGCAGCTTGATGCAAATTCCCTGTTGCGAAAATTAAAAAGAATAGGGTAAGTGCAATGGAAAAACTTGCACCACCGATATGGGTAATATTGCTGAAAAAGATGTTTAATGTTTTTTGATCAAAGTAGCGATTAATTCCTTTGAAGATGTAACATTCTATTTTATATAGTCCACTGACCTTCATGAGATTTTTCCTCCCTCATTTACATATATATGGAGTTATTAACTTCTATTTTAATAAGATTTTATTGAGGGAATAATAATGTTTTGTAAAGAAAAAGTTAGATTTTTTCATAAAAAAAGCTGCCAGTCTTATGGCAGCGATAAAATCACTTTTGTAACGATTTATAATATTGTCCTTTTTCAACGTATTGTGTGCGGATACGTTCCATATCTTTACGGTCTTCTTCTGTTAATTCGCGAATGACCTTCGCAGGGCGACCGAAAGCTAACGTATTAGGAGGGATTTTCTTTCCTTGTGAAACGAGACTACCAGCACCGATGAAAGCTCCTTCACCAATTTCAGCGCCATCTAATATGATAGATCCCATTCCGATTAAAGCATCTTTTTCAATTTTGCAGCTATGTAAAATAACTTGATGCCCAACGGTAACGTCATCTTCTAAAATAAGAGGATACTGGGGGCTTTGGTGAAGTGTACATTGATCTTGTACATTTACTCTATTTCCAATTATCGTTGGTGATACATCACCGCGGATGACTGTATTAAACCAAATGCTAGATTCTTCGCCAATTGTCACATCGCCTGTAATGGTAACATAGTCAGCGATAAAAGCACTACTCGCAATTTTCGGATTTTTTTCTTTGTAAGGATATATCATGTAAAGCCTTCCTTTCCTAGAGACTAGTTTTAGTGTATCAAATTATGAGAAAGAGTGAAATGGAGGAGGTCCGTATGTGGAATTATGAAGCAGAGGAAGCGAAAGCTGTAGTCGTTATCGTGCACGGCGCAATGGAATATCACGGACGTTACGAAGCTATAGCAGAAATGTGGAATCATATCGGCTACCACGTTGTGATGGGAGACCTTCCATCACATGGAACGACTTCGAGAAATAGAGGACATATTGATTCATTTGATGAATACATAGAGGAAGTTAAATTATGGGTGAAAGAGGCAAGGAAGTATCGATTACCTATTTTTATATTTGGTCATAGTATGGGTGGTCTTATTGTCATTCGTATGATGCAAGAAACGAAGAGAGAAGATGTAGATGGTATTATTTTAAGTTCACCATGTTTAGGTGTATTAACTGGACCTTCTGCTCCGCTTCGAGCTGCCTCAAAAATATTAAATGTTGTTGCTCCAAAATTGCAATTTGCAACGAATCTTACAGTGGAAATGTCAACTCGTAATCATGAAGTGAGAGATGCGATGGAGAATGATTCATTGTTCTTGCGCAAAGTATCAGTACGTTGGTATAGTGAATTGATTAAGTCTATCGAAATTGCGCATAAAAAAATAGGCGATTTTCCAGACGTTCCACTCTTGCTAATGCAGGCTTGTGAGGATAAACTTGTAGATAAAACACGTGTCCGTACTTGGTTTGATAATGTTAAAATAAGTGATAAGGCTTTTAAAGAATGGCCGAATTGTTATCATGAGTTATTAAATGAGTATGAGCGTGATGAAATTTTGAATTATATTCAGTCATTTACTGAAATACGCATCAATAACATAATAGAAACAAATAAGTAAATTATTTGTACATTGAATAGAGGAGATGAAGGAAGAAGTGAACGTACCGAGTAATCCCATAACGCTCATGGCGAAAGTATACCGTGATGTGTTTCCGGTAGTACACCATGAGCTAGCGATGTGGAAAGAGCGTGCCTACCATATTCCGAATGACGAGCTTCATAGTCAGGCAATCGCAAGTATTGAGAATAAAACGTTTCATTGCGAGGGCGGTGGCATTTTAGCGCTACTAGCAAATGAACATCGTGAGGAATGTATTCGTTTTATCGTAGCTTATCAAACGATTAGCGACTATTTAGATAATTTATGTGATCGTAGTACATCACTTGACCCGAAAGACTTTGCGGCTCTTCATGAGTCGATGGTAATGGCATTAAGCCCTGAAGTTGAAGGGGGCGGTAACTATTATCGTTATCGTGATGATCAAGATGATGGTGGTTATTTAGATGAGCTTGTTGAAACATGTCAGGATGTTTTAAAGAAAACGAAGCATTATGATAAAATTGCTCCAATTCTTCATGAACTTGCTTGTTATTATTGTGATTTGCAAATTCATAAACACGTGAAGTTAGAAGAAAGAGAACCACGCTTAAAAACATGGTTTGAAGCGCATAAAGAAAATTTACCACCGATGAGTTGGTTTGAGTTTTCAGCATGTGCAGGTTCTACGCTTGGAATTTTCTGTCTTGTCGCATATGCATTTCATGATGAATTACATGATGAAGATATTGCGAAAATTAGACAAGGATACTTCCCTTACGTACAAGGACTTCACATTTTACTTGATTATTTCATCGATCAAGAAGAAGACCGTATAGGCGGGGATTTGAATTTCTGTAGTTATTATGAAAACGAGCAAGCTATATTAGATCGTATGAAACATTTTGTAGAAGAAGCAGAGAAGAGCATTGGTGATTTGCCTCATGCGAAGTTTCATCGTCTCATAAGCCGAGGATTACTTGGTATTTATTTATCAGATCAAAAAGTATCAGCGCAAAAGAATATGCATAAAATGGCACGGCGCATTGTAAAATACGGAGGGCTCACTTCACGATTCTTCTACTGGAACGGGAAGATGTACCGAAAGAAAATGGCGCAGTGATGAAGAGACCATCTCAAAAGGTATTTTGGGATGGTCTTTTCCTATTGTCGTATTTTGTAGTTAAGTCGATATAATTTCATGTGCTGTTGCAATCTTGCTCCATAATGAAAAAGGGACAGTCCAAAATTAGATTTTTTGGACTGTCCCTTTTTACTATGATCGTATTTTTAAAAATACATATATGAGAAGTTCAATCGCGAAAATTACTAAAACAGATAGTCCGAATAAAGGCATGACAGCGCCTAGTATAACCATCATGATAAAGAAAACGATTATGCTTTTCTTATCTCTTTGCTTTGGCGGTGCTGCTAATTTTCCTTTTGGCTTTCTTGCTAACCACATTTTTATTCCGTAATAAATGAGAAGTAATAAAGATAATGTCGTTAGTAAGCATAATATTTTATTTGGCCATCCGAATAAATGTCCTTCGTGAAGCGGGATACCGTAAGTGAACCATTGTGCAAATAATCCATAATCACGATAGTCCGTTTTCGAAATGAGTTCTCCGCTATATTGATCAAAGTAAGCTGTTATTTCTTCATTTGGTGCGACATGCATACCCGTAATACCGGAACCGCTTGATTTCGAAACGGTGAATACACCTTTCGGATCAGCCGGTAGGGAGATAACATATGGCTTCTTTATTTCAATTCCTTTTTGTAATTCATCGACAGAAATTGCTTTTGGCTCATTTGAATTCGATTCAGGAGGAGCTTCTTTTCTTGTTGCCCACGGCAATTCTTTTACCTTTGATTCAGGCGGTGCCATATACAACTTTGGATATCCAATCGATTCATTCGACGATGCGATTTTATAAATTTGGTTACCCATAAATCCTGACCAAGGCAATCCAGATGCGACTAGCAGAACGAGTGGAATTGTAAATATAATACCGATAATAGAATGACGTCGTTTTGCTTTTTCTCGCTTATTGGATGCTGGTGTGTTTTTGAATTGGCGTATACTCATATACAACCCAGTCACAATTAAAAAGATTGTCCAGCACGCTGCAAGTTCTACAATATAATTGACGACAGTGCCACCGACTAAAAGGGAACTATGTAATTCCCGCATTATATTGGAAAACGTTTCAGCTGTATTTTGATCCCCAACAATTTGATTATTGCTATCTAAATACACAAATTTTTGCTTTCCTGTATATTCATTAGCAATCGTAAGCCTAGTATTATAATCCCCATTAAACTCACTAATTTTCGTCACGCTATAATGCGGATATTTTTTCTCTGTTAAGAAAAGCGAATCAGCCATCGAAATAGATTCTGTTTGGGCGCTCTTCCCAAAATATAAATCTTTATAGATGAAATCTTCAACTTCCTCACGAAATAAATACCCAATTCCGCTCAGTGACAAAGTAATAAGAAGCGGCGTAATAAAAAGCCCGGCATAAAAATGCCAACGCCAAAAAATATAATGAAGCGAACGATTTTGTTTCATACGACAGTTCCCCTAACCTTCCCTATATGAATAAACTACTTATTTAATATAGCGAGATTAAGTGTGATTACTTTGAAAGAATTGTGAAAAAAGTTAAAAGTTTTGGGGATTTTTATCAAACACAAAGCACATTTCAAAAGGGATGTGTTTTATGTTTATGAAGACCTTTTTATATTTGATGCATAGATCCTAACAACTGCTTCCGCAAGACATTGAGCGGAATCAACAAAGTCCTCACTCACCACCACATTCAAATCGGTACATGCGATAATAGCGGTATCTACTTCGTCTTTTAACTGTAAAACGAGCAGACTCCATAATTTGCGAGCTTCCTCAATTTCTCCGCCTTTAATACAAGTAATAATTTGATTAATCATTTCTTGCCATTGTTCATTATGAATGTACTCTATATTACGTTTTGTAATCCCGTCTTGGTAAATACCTGCTTGAACAGTCGCTTCTGTTGCAAGAAGAGCGACTCTTTTTGTATTTTCAGGAATTGCTTTTAACGTCTCATCGACTATATTCAAAATAGGAATGGTAATAGAACGCTGTAATTCTTCGAAATAAAGATGCGCTGTATTACATGGCATTGCGATGAAATCTACACCAGTACTTTCAAGTCTTTGCGCTCCTTCAATAATCGCTTTTTTCATCGCCGCATGATCAATAGGGCGATCCATATAAAACGGTGTTGGGCACGAATAAATCATCATATGAGGAAAGTCCATATCATGCTTTGCTCCATATATTGTTTGGCACCCTGCTACAACTGTATCGACGAATGGTCCGGTTGATTTTGGACCCATTCCTGCTAGTATTCCAATCATTGTTTAGTCCCCTTTAATATGTAATCAAAAACGTTTTCTGCGAACGAGAAAAAGAAATAAAGTAAGTAATAAAAATGAATATACGATAGCCCAAGCTGTAAGCCATAGAGTATGAGTAAGTATATTATATTTGTATTGTCCAAGCATTATAAAGCTTTCGACAGGTGGTAAAAACCATAGTAACTCTTTTTTTAACCGGATTGAGGCAATCGTCATAAGTAATATAAATGTAAGACTAAGCCAAGCGGTGCTTGCTTTTTGAATAATATTTCTAGTAAATAATGTTGCGATTGAAATTCCTAGTATAGATAAAGACATGTGAGCGAGAAATCCGACTAGAAATAAAGAAGCTGTCATTTTTTCATTAAACATTTGCAAAATAATTGGATAGATTACGGATATAAAAGATAAAACAGTACAAATAAGAAGAGCCGTAACATATTTACCAACGTATAATGCCGAAATATTATTTGTATGTGAAATAGTGATTTGTTCTTGTACAAGATCTTCAGTATGAAAAATTGTGACTGTAATCCAGGCAGATAATAAATAAAGTGCGAGTGCTGTTTCTAAGTATGTCGGTACAATGGGAGTTGGTTTATATGTATATACAAAAAGTAAGCTTATGCAGTACATCGCAATAGGAGGAATGTACTTATACGATTTTGTGTAGTCGAGAAAATGGTAACGAATAAGCGCAAACATAATAAACCTTCTTTCGATTTAAAAATTAGGCTGTAGCAGTGTGATAGATGCTTTTTTATGTAATAAAAACTGAAGCATTTCGTTTGTATATTCCTTTTCGATTTGTAATTGAATGAGGTTTTGATTTGAATTGTGTGTAACTTGTATAAATCCTGATTGCTTTTGTAGTTCTATAGATGAAAATGTTTCGTGAACAATTGCCTCAATATAGACCTGTTCTGTTGATTTTTGCACAGAGGTATCTTCCGCAATTGTATGATTTGCTAATGTCACAATTCTATCGGCGAAGTTTTCTAGTAGTTGTTTTTCGTGACATGTGAAGAGTATAGATATGCCTTGTTGTTTTAATGAGAGTAAAATATGCTCTAGTTCTTGCTGAGAGTTAGGGTCGAGTCCGGAAAGAGGTTCATCTAAAATTAATAAATGGACGTCTGTAAGTAACGCTTGCATAATGCCTGTTTTTTGTTTCATACCTTTTGAAAAGTTACGTACAATGGAATGCTTTGCATGATGTAAATGAAAAGATTCAAGGAGGATCGGAATTTTATTTCTTAAATATTTTGTTGATAAACCGTGAATGTGGCCGAGATGATATAAATAATCCTCTAATGTAAAACGAATTTCTTCTGGAAAATGTTCAGGAACATATCCGATTTGTATATGTTCTTTTCTTTGAAGTGTCCCTGCCGTAGGTGAAATAAATCCTGCAATTATTTTGAGTAGAGTACTTTTTCCAGTCCCGTTCCCGCCAATAATAGCGAGTGCTTCTCCTTCTGGAATGGATAAATCGATGTTGTCTAGTATGAGTGATTTGCTGTACTTCTTTTGAATTCCCCTTAGTTCTACTAGCAAAGTTCTATCCTTCTTTCTTCAAATATTGTATACATCCATTATATAGGAGAATAAGAAAAAGACGTGCAATGAGTGCACGTCTTTTTTTGTTATGTTTTGTCGAACAATCGATATATCTGAAAAATCGTTGATATAATTATCCCGCTATTTGCCGGACAGTAAACCTCACTGATTAAAGTTTCACTTTATCGCTTCTCAATCGCCACAATAAATGGTGGGTTATTTTGCTGGTTAATGAAGCCGTATCGCAAAACGTGAGCTTGTTTTTGGTCGAGTTCTTCTGCAAATTTGAGAACAGCGTCGCGTTCTACTTGTCCTTCTGGATGTCCGTGGTAAATGACAAGGACGATGATACCTTCAGGTGCCATTACTTCTAATAATTGCTCGATCGCCGAGATTGTTGAGTTCGGTTTTGTAACGATATGTTTGTCACCGCCAGGAAGGTAACCTAAGTTGAAGATAGCGCCTGTTACTTTTCCTTTTGCTTCTTCTGGTAGTACGGATAAAAGTGTATCGTGACTATCGTGAACTAAAACAGTGCGTTCGAAAAGTTCTTTTTCTTTTAGGTGGATAGTAGAACTTTCGATTGCTTCTTGTTGTATATCAAATCCAAATACTTTTCCGTTATCTCCAACGATTTCAGCTAGGAAGCAAGTGTCATGCCCATTGCCGAGTGTTGCATCTACAGCGTAATCGCCTTCTTTTACTGCCGTTTGCAGCAGCGAGCGAGCAAACGGTAATACACGTTCTAATTTCATTTTTGTTTCTCCTCATTTGCATATTTTCCTTGCCAGCTTCCGCGGCGTACAAATTCTGCATCGATGGAATTTAATACTTCCCATTTATTTAAGCTCCACATTGGACCAATCATTAAGTCAGGCGGACCGTCACCTGTGATGCGGTGCACAATTACGTCTTCTGGAATCATTTCAAGTTGGTCAACAACGAGACTTACGTAATCTTCAAGAGAAAGGAATTCTAGTTGTCCTTTTTCATATTGCTTCACCATTGGTGTTCCTTTTAATAAATGAAGTAAATGAATTTTAATTCCTTGTACATCAAGCTTCGCTACTTCACGAGCTGTTTCCATCATCATGTCGTAATCTTCAAGTGGAAGACCGTTAATAATATGAGAGCAAACTCTAATGCCATGTTTGCGTAATTTATTTACGCCTTCCACATAAGATGGATAATCGTGAGCACGGTTAATAAGATTTGCAGTGCGTTCATGAACAGTTTGTAGTCCGAGTTCAACCCAAAGGTATGTACGTTTATTTAAGTCCGCTAAATATTCAACGACATCGTCTGGTAAACAATCTGGACGAGTTGCGATAGAAAGACCGACAACGTCTTTTTCTGCTAGAAGCGGTTCGAATTTTTCTTTTAACACTTCAAGTGGTGCATGTGTATTTGTGTAAGCCTGAAAATAAGCGATACATTTTCCGTCTTTCCACTTTGAGTGCATTTTTTCTTTCATTTCATGATATTGCGTTATAACATCATCGCGGCGATCGCCAGCGAAGTCACCAGATCCAGCAGCACTACAAAACGTGCAGCCGCCGTAAGCGACTGTACCGTCACGGTTCGGGCAATCGAAGCCAGCATCTAATGAAACCTTAAAGATTTTTTCACCAAATTCATTTCGTAAGTGGTAATTCCATGTATGATAACGTTTATTGTCATTTGTATATGGAAAAGGGTTTTGAACCTTCATTATTTTCCCTCCTAAGACGAGTCAAAATGAAACAAAATCCATTATAACATACTCATAAGGTTCATATGGAAGGGACACACTAAAGGGGAATTGAAGCAAGGAGGGACAATTATGGCAGAGCGTCAATCACTTGAAGAGTATATTACACAGGCAGAACAAGCGGTGGAATATGCGAAAGAACAATTAGACCAAGGCATGAGACAGGAGCATTACAATACGATGGAGTATTCGGATGCTCAGTTGCAATTAGAACAAGCATATAATGATTTACAAACGATGCAACAACATGCGAATGATGAGCAACGTGAGCAATTAAATAGAGCACGTATGGCAATTCGCCAATTGCAACATCAAATGATTATTACACCGCACTAATAAGGAGTGAATGTAATGGCGAAACGTTCAGATCAAAACAATCCAGAGCAAAAAACGCAAAACGGACATAACGCTGAGTTTTCGAATGAACTTGATCCAGTTGTTCAAGTGAAACAGCGTAATAGTAAAAAAGGACAACCTCAAAGATCAAAGCAATCAGAGTAAACCAGGTCGCATTATGACCTGGTTTTATTTTGCCTCGTGATTGGTGCGGGCTAATCAAGGGGCAAAATAATACTGATTAAAGATTTAATTCATTATATTACAATAATGTAAGATTACTGTAAGGTTTGCCGATAGTTACGATTGTCTTTTTCCAGTAGAGTAAGGGAGGATTTAATTTTGGACAAGGAGTTGTATTATGGGGAACAATATTACAAACAAACGAATTGATGAGTTAGATTACATTCGTGGCTTCGCATTACTGGGGATTATTTTAGTAAATATTCTTGCACTACTGAATATTAAAGTTCCAGATCCTAGTACAGTGGATGCAAGTTATCAAAGGTTTCTATACTTATTTGTAGAAGGTCGTTTCTTCTCAATCTTTTCATTCTTATTTGGAGTAGGATTCTATATCTTCATTACAAGAGCAATTGCGAAAGGGAAGAATGGATATGTTCTATTTCTACGCCGCTTAGTTGCACTATTTATTTTTGGTTTGATTCATCAAATGTTTCAGCCTGGGGAAGCACTAGCGTTATACGCAATTTGTGGATTAGTCACTTTACCATTTTATAAAGTGAAGAAGCAAATAAATTTAGTAATCGGTCTTATTCTTACGATAGTTTTTAGTATTATGGCAGCTAAGGAATTATTACCATTAGGTTTAATTTTATTAGGTCTTGCTGCAGGACAGTACAAAGTATTTGAAAATCTTTCAGCGAAAATAAAGCAAGTCGCTATTTTTACAGGAGTTATGTTTGTTTTAAGTGTGATAGCTTTATGGTATCAATATGGGCACGTTCCTGCTAATCCATTTGTAAATATGATACTTATGACTGAAGATGGAACAATGGACGCTGCAGGTCAATTCTTAAAAATTGGTGTTACAGTTGGACCAATTATTTCAGCTTTCTATGTAGGAGCATTAATTTTATTACTTCAGTTAAAACCAGTTCAAGCATTGTTAGCGCCACTGAAATACTATGGTCGTATGGCTTTAACAAATTATGTTGGACAAACTGCAATGATTTTAATTGCAGGCAGTGTATTTAATTTTGCAGGAAACTTAACGTACATGCAGACGCTATATGTGTGTATCGCAATTTATGCAATTCAAATTATTTTCAGTGTGATTTGGATGAAAATCTTTAAAATGGGTCCATTAGAATGGATTTGGCGTGTTATTACGTATTGGACGGTAACGCCTTTAAAGAAATAAGAGTAGGAAATAGGCTGTTCCACATGCGAAACAGCCTATTTTTATTGTCATCTTTTGTCGGTAAGTCGATATATTTGAAAAATCGCTGATAAAATTGCATTTACTAATGAAAAAACTAAGCTTACATGCTCAGTTTTTTTTCTTACAAAAGTGTAAGGTAATTGTAATGTTAATAAATAGCAGTTCACCTCCAAAAGGCGCAAAATAGGTAATGGAAAAACAAGCGTAGGAGGATATATATGACGAAACCAGTTGTAGACGTGAAAAACGTTCAAAAAGTGTACGGTAAAAAAGGTGAGAACCAATCACACGCGTTAAAAGGTGTTTCATTCTCAATTCAAGAGGGTGAGTTTGTTGGTATTATGGGACCATCTGGTTCTGGTAAAACGACATTATTAAATGTAATTTCAACGCTTGATAAAGCAACGGGCGGCGTTGTTGAAATTGCGGGTACGGATATTACGAAAATGAAGCAAGGTGAGCTTTCTGATTTCCGTTCACAAAAATTAGGATTTATCTTCCAAGACTTTAACTTATTAGAGAACTTATCTATTTATGAGAACATTGCACTTCCACTTTCCCTTCAAGGTGTTTCATCACGTAATATTGGACCGAAAGTAGAGAAAGTAGCGGATATGTTAGGGATTACAGAAATTCTTCAAAAGTATCCAACTGAAGTATCCGGTGGACAGAAACAACGTTCAGCAGCAGCACGTGCACTAGTGCATGAACCGGCAATTATTTTAGGAGACGAGCCAACAGGAGCTCTTGATTCGAAAAATGCAGCAAGTTTACTTGATGCGATGACAAACTTAAATGAAGAACAAGGCGTATCTATTATGATGGTTACGCATGATCCATATAGTGCAAGTTACTGTCAGCGTATTTTATTCATTCAAGATGGTGAGCTATATAAAGAAATTCACCGCGGTGGTACGCGTGAAGAATTTTATAAAGAAATTTTAGATGTGCTTGCGGACTTAGGCACACAAAAAGCGTAAGAAGGGAGGTCTAGGGCATGTTATTTAAACTTTCCATGTCAGGGCTAAAGAGTAAGCTGAAAGATTATATTGTCTTACTTGTTGGTCTTGTCATGTCGATTTCAATTTTTTATATGTTCCAAACGTTAGCGCTGAATAAAGCGTTTATCGAATCCAATTCTGTTATTAAGTCTATTGGTTTCGTATTCCAAGCAGGTTCATTTTTATTAGCAATTATAACGTTCTTCTACATTTTATATGCAAACTCTTTCTTATTATCTCTTCGTCAAAAAGAGTTTGGTATGTACATGATGTTAGGTGCAAAAAAGCATAAAGTTACATTACTTATGTTTATTGAAACGATTGTATTAGGTGCTGCGTCTCTTGCGATTGGACTTACAGTTGGTGTAGGACTTGCAGAAGGTATCGGACAGTTATTAATGAAACAATTAGAATTTGCTGGTGAAGGCTATAAGGCATTTTATCTACCATCTATGACTGTTACTTGCATTTTCTTCTTTGCATTATTTGTATTATCAGCAATTATGAACAGTATTAAGTTATCACGTATTTCAGTACTGCAACTTGTACATGCAGATGCACAAACAGAACGTGTTGCGGTAAAAGGAAAAATGACAGGTGTCGTTGCAATCCTTGCTGTTATTTTATTAGGAATTGGCTATGCATCAATGATTTACATGGAAAAACTAAGAGAAATGGGAATCCTTATTGCATTAATTACAACAACAACTGGTACTTACATGCTATTTGGATCACTTCTCCCAGTTATCATTAGAAAGTTAAAGAGTAATAAAAAGCGTAGTGAAAAAGGACTTAATGCTTTTACGTTTGCACAATTAAATTTCCGTATTAATAGCTTAACGAAAGTACTTGCAACAGTAGCGATGTTAGTTGCTCTTGGAGCGGGTGCAATTTCAGGTGGTATGGCGTTTAAAAATAACGTTATAAAAATGGTTGATGGTTTAGTAATATATGATTCAGTTATTCATAACCCAACAGCTGAAGAAAAGAAAATTTTAGATGGTATTACATTTAAAGAGAAAAATGAATATCGTTACAAAGTTGATAATAAATACGTTTATTATGTAAAAGAAGATTTAGAGAAAAAACCTCCTTTCGTACAAGATACAAAACAGATGGAAAGTATGAAGGATTTAGGAAAAACAAAGAAAGTTTCAGAGGAACTACCAGTAGGTGCAGTTTCTAGAGAAATGAATGAAAAAGATGCGAGTGCTAAAGAACTTCCAGAAGAATGGAACGAGGCTTTCAGAACAATTCAGCCATTTTATCTATATGAAGATCATGCAATTAAAATTGTAGATCAGAAAATGTACGATACTGTAAATGGTAAAGAAGGAATCGTAGTTACTGGAAAAACAGACGATTTTGTAGCATACACAAAAGAATGGAAAAAACTTGACGAGTTGCAGCTAGTTAAATATAAAAATGTAAAAGCTGAAAGATTAGATAGTAAATATCAATCTTACAATGGATTCTACGGCATTGCGAGTGGAACAGTATTTATGGGATTCTTCCTTGGAATTGCATTCTTAGCAATGATGGCAAGTTGTTTAATGTTTAAAATTCTTTCTGGGGCATCAAAAGATATTACGCGTTATCAAATGCTGCGTAAAATCGGTGTGCGCCGTGAATTATTAACGAAATCAATTTATAAAGAGTTATTCTTAGTATTCTTATTCCCGGCAATTGTGGGTATTGCTCACGTATTAGTTGGTATGAATATTTTCGGATTTATTTTAGTCGATCCGTACTTCCGCATTTGGGTTCCAATCGTAATTTTCGTAGTAATTTATGCGATTTATTACTTCATTACAGTTCAATTGTATAAAGGGATTGTTCTTCCGAAAGAAGATTAATGAAAAACCGAGCGAAACTGCTCGGTTTTTTATATTTTCAGAAAAAACACTTTAATGTTACTGAAATATATAATATAATGTAAATAAGTAACATAATATGTGAGTATCAGCAACTGGAAAACGAAAGGAGGAATTCGATCTATAGAAAGAAGCTGAACTTGTATCCCCTATTTTTCTACCCACACTGTATTTGTACAATCATAAATTTCCAAATGCAAATTGCCTGGACCTAAGCAGTATATTGTGAAAATAATGGATAATACATGGAAATCTCATAGCATGATAAGGTAAAATGGACAGGATAATGAGAAAATTACCGTTCATAAGATGAGGAGATACATGTATGGAAGTTGTAGAGGCATTAAAAGATATAAACCAAATTGAGGCTATGAAAAAGTATTTAAAAGAGCACTCGCAGCGAGATTATCTTTTATTTGTTATTGGGATTAACACTGGATTAAAGATTACTGAACTATTGAGTATTAAGTTTGAAGATGTATTAAATGAAGATGGAACTGTTAAAGAGTTTTATTCTCTTCCTGTGAAAGATGAAAAGTTTAAACAAGATATTTATTTAAATACAAAAGTAAAAGAGGCGCTTTTAGCGTACGTACAATCTTTTGATATTCAAAGAGAAAACTACGTATTTCAATCTAACAAAACAACAAATTCAATCTCACGCCAACAAGCGTATCGTGTTATCCATAGCGCAGCTGAAGCGGTCGGAATACTTGGTAAGATTGGAACGAACTCAATGCGAAAAACATTTGGATTTCATGCGTACAAAAGAGGAATAGCGATTGCGCTATTGCAAAAGCATTTTCATCACGCAACTCCATCAGAAACGTTAAAGTATTTAGGAATCTTAAAAGATGAGAAGTTTAAAACAGAGATTGATGTAGATTTGTAAAAGGAAAGAGCCGTAACTAAAAAATTAGGAGGCGGGAATATGAATATTAGAGAGAGTGAACTACCGGGCATTGGATGTAAATTTGAAGTGATAACAAAGGGTAATGAAAAAATGGTTATTGTTATTCATGATGATGGAAGAAGGGAAATGTACCATTTTGATGCGGATCACGATGAGAGTATTTCAAGCATTTCTCTTCGTGATTCTGAAGCGAGACAAATTGCGGCTATATTAGGCGGAATGGTATATAGGCCGCAAGCGCTAGACACAATTGAGATGGCTTTTGAAGGATTATCAATTGAATGGTTTAAGGTGGAGAATAATGCACCAGTAGTACAACAAACAATTGGGAGCTTACACGTTAGAAAAACATATAACGTAACAATCATTGCTATTTTGAAAAAGAATATGAAGAAATTCTTTAATCCAGGTCCAGACTCTATTATTGAAGCTGGCGATATGCTCGTATTATCGGGTGAAAGACATGAAGTAAAAAGAATTATTAATGAATTGCTTTCAGCAGGAGGTGATTCCTAATCGATGGATACTTTAATTTTTGAAGTTGGAACTGCGTTAGTATTAGTAGCTTTTGCAGCTATCCTCGCTGCGAAGTTAAAGTTCTCGATTATTCCGTTTCTCATTATACTCGGTATGTTAGTGGGGCCTCATGCCCCAGATTTAGGACTTATCGATTTAAGGTTTATTGAAAGCGGAGAAGTTATTTCCTTCCTCGGCCGTGTTGGCGTCATATTCCTCTTATTCTACTTAGGTTTAGAATTCTCAATAAAAAAATTAATTAAATCAGGAAAGTCGATTGCTTTTGGGGGTAGTGTTCATATATCGCTTAATTTCATATTAGGTTTACTTTATGGATATGTTATGGGTTTCCCCTTATTAGAAACATTAATTATTGCTGGAATCATTACAATCTCATCGAGTGCAATTGTTGCAAAAGTAATTGTTGATTTAAGAAGATCTGGTAATAAAGAGACAGAACTCATTTTAGGGATCATTATGTTTGATGATATCTTTTTAGCTGTATATTTATCAGTCGTTTCAGGATTAGTACTCGGAGGTGCAACATCATTTGTAGGTGCTCTTACATCCGTACTAATCGCAGTAGGATATATGTTACTATTCTTTGTAATCGCTAGAAAAGCTACGCCGTTTCTAAATAAAGTATTAGATATTTCGTCAAACGAAATTTTTATTATCGTAATATTCGCTATTTTATTCTTTGTAGCAGGATTTTCAGAAACAATTCATGTTGCGGAAGCGATTGGGGCTTTATTGTTAGGACTCGTCTTTTCAGAAACAGAGCATAGTGATCGAATCGAGCATCTCGTCGTCCCGTTTCGTGATTTCTTTGGAGCTATATTTTTCTTCAGCTTCGGTTTAAGTATAGATCCGTTTTCGCTTGGAGGAGCAGTATGGTTGGCATTAGGAGCAGTTTTCATTACTCTCATCGGTAATTTTACAGCTGGAATGATTGCAGGGCGTAAAGCCGGGTTATCGCATAAGGCTTCTGCGAATATCGGTTTAACACTTATATCACGTGGGGAATTCTCCATTATTGTCGCGAATCTCGGAATAGCGGGTGGCTTAATGGCAACGATTAAACCATTCTCAGCTTTATATGTTTTAATATTGGCGTCGTTAGGGCCATTATTAACGAAGGAATCTGGGAGAATATACTCTCTACTAGACAAAATATTTAAATGGAGTGCTAAAGAAAGTGCAAAACGTAAAAAGGAAGTTGGATAACCTTCCGCTAGGGAACGATTCCATTATTTATAGATTAATATTTTACAAAGACGATTAGAATACATTCTAATCGTCTTTGTGCTATTATCTGAATTTCATCAACTATTAATCAGTTGCCTTCCTATTTAAAAACGACTACAATTTTACTGTTATATATATGAACGAAAAAAAGAGAATAGGAGGGGAGACTATGCCAAGGAAAGTATGGCTATTAGTAGCTGGGATGATTATTAATGTCACGGGTGCTTCTTTTTTATGGCCTTTTAATACAATTTACTTACATGATAGTTTAGGGAAATCTTTATCAGTAGCCGGAATGGTATTAATGATCAACTCGCTTACTGGTGTAATCGGAAACTTGCTCGGCGGTGTTTTATTTGATAAATGGGGCGGTTATAAATCAATTTTAGTAGGGATTGTCATTACACTTGTATCGATTTTAGGTCTTGTATTTTTCCATGGTTGGCCATTATATGTTGTGTGGCTAGCATTAATCGGATTCGGTTCTGGAATGGTATTTCCATCGATGTATGCGATGGTCGGTACGGTTTGGCCAGAAGGCGGGAGACGAGCGTTCAATGCAATGTATGTTGGACAAAACGTTGGGATTGCGATTGGAACAGCGTGCGGTGGATTAGTTGCGTCTTATCGTTTTGATTATATTTTCTTAGCGAACTTTATTTTATATTTTATTTTCTTCTTAATTGCGTTTATTGGATTTCGTGGTATGGAAGCAAAAAAAGAGCAAGAGGTACAAAAAGAAGCCGAAACGAAAAAAGGTTGGTCACTTACACCTGGCTTCAAAGCGCTTCTAATCGTATGTGTAGCATATGCTTTATGCTGGGTTACATACGTACAGTGGCAAGGGGCAATTGCGACGTATATGCAAGAGTTAAATATTAGCCTTCGTCACTACAGTTTATTATGGACGATAAACGGGGCGATGATTGTTTGTGCACAGCCGCTTGTTAGTATGCTAATTCGCTGGATGAAGCGTTCTTTAAAACAACAAATTATGATTGGAATTATCATTTTTGCGGCGTCGTTTATTGTTTTAAGCCAAGCGCAGCAATTTACGATGTTTCTCGTTGCGATGGTGACATTAACAATTGGTGAATTATTCGTATGGCCGGCAGTTCCGACCATCGCAAATATACTTGCACCGAAAGATAAGCTAGGATTTTATCAAGGTGTTGTAAATAGCGCAGCGACTGTAGGGAAAATGTTCGGACCGGTCGTTGGCGGAGCGATTGTTGACTTATACAATATGGAAGTATTGTTTATTGCGATCATGGTAATGCTTGTAGTAGCGCTTATAGCAACGAGTATTTATGATAGACGAGTAAAAGTAGAAGAAACAGTTGAAGAAAAAATTGCAGTTTAGTTTGACGGAACATGCAACATGTTTTAGAATATATTTAAATAAATAGTAATAAAATATCCTTTGGAACAAGGGAGTTAGCTCGGCTGTCCTAAGAAAAATTCGTTAGTTAGCAAGAGTAACGATTAACCGAGAAGCCCTCGCTTCAAGTAAGCTCTTAAGAGATACTAAGTGGTGGGTAGTTCACATTAACTCATATTTGTAATAACAGTGAGAAGGAGTAGTAGTAATAGAAGCTGGTTTAGAGAGTTGACGGTCGGTGCAAGTCAATCCACGTTTCGTTATGAACTCGCCTTTGAGTTGCAGTTGTGAAATCATTAGTAGCAATTGCCGTTAATCCACGTTACGGATCTAAGCGAATGTATTTATTACATTAATTTAGGGTGGTACCGCGGGAATCTATAACCTCTCGTCCCTTTCTAGGGATGAGAGGTTTTTTGTATTTTGGGCGGTGAAAATAAATAGAATTTCAAGGAGGGTATCTCATGAGCTTTAATCATCAAGAAATTGAGAAGAAGTGGCAAGGGCATTGGGAAGAGAATAAAACATTCCGTACGCCAGATGAAACAGAAAAACCAAAATTTTATGCACTAGATATGTTCCCATATCCATCAGGTGCAGGCTTACACGTAGGTCATCCAGAAGGTTATACAGCGACAGATATTTTATCTCGTATGAAGCGTATGCAAGGATATAACGTTCTTCATCCAATGGGATGGGATGCATTCGGTCTTCCAGCAGAGCAATATGCACTTGATACTGGGAACAGCCCGGCTGAATTTACAGAGCTTAATATTAATACGTTCCGTAATCAAATTAAAGCATTAGGCTTCTCTTACGATTGGGATCGTGAAGTAAATACAACAGATCCAACCTACTACAAGTGGACACAATGGATCTTCCTAAAACTATTTGAAAAAGGTTTAGCTTACGTTGATGAAGTACCTGTAAACTGGTGCCCGGCACTTGGTACAGTACTTGCAAACGAAGAAATCATTGACGGTAAGAGTGAGCGCGGTGGACATCCAGTTGAGCGTCGTCCGATGAGACAGTGGATGTTAAAAATTACAGCTTACGGAGATCGTCTATTAGAAGATCTAGATGAGCTTAATTGGCCAGAAAGCTTAAAAGACATGCAACGTAACTGGATCGGTCGTTCTGAAGGTGCAGAAGTACACTTCAACATCGACGGTACAGATGAGAAGTTCACAGTTTTCACAACGCGTCCTGATACACTATTTGGATCAAGCTACTGTGTACTGGCTCCAGAGCATGCACTTGTTGCTAACATTACAACACCAGAACAAAAAGAAGCTGTAGAAGCTTACATTAATTCTGTAAAAATGAAGAGTGACCTAGAGCGTACAGAACTTGCGAAAGAAAAAACTGGTGTATTTACTGGTGCTTACGCAGTTAACCCAGTAAACGGTGAGAAATTACCAATCTGGATCGCTGATTATGTTCTTGCAACTTACGGAACAGGTGCTGTAATGGCAGTTCCAGCTCACGATGAGCGTGACTATGAATTCGCATCAACGTTCAATCTTCCAATGAAGGAAGTTGTAAAAGGCGGAGACATTTCGAAAGAAGCATATACAGGTGATGGTGCGCACGTAAACTCAGCATTCCTTGATGGTTTAAATAAAGAAGAAGCAATTGTAAAAATGATTGAGTGGCTTGAAGTAACAAGCGCAGGAAATCAAAAAGTAACGTACCGTCTACGTGACTGGTTATTTAGTCGCCAACGTTACTGGGGTGAGCCAATTCCAGTAATCCATTGGGAAGATGGTACAATGACAGCTGTGAAAGAAGAAGAATTACCATTAGTTCTTCCGAAAACAGAGAATATTCGTCCTTCAGGTACAGGTGAATCACCACTTGCAAACATTGAAGAGTGGGTAAATGTTGTTGATCCTGAAACTGGTAAAAAAGGTCGTCGTGAAACAAATACAATGCCACAATGGGCTGGTAGCTGCTGGTACTACCTACGCTACATCGATCCAAACAACAGCGAAGCACTTGTAGACCCTGAAAAAGTAAAACAATGGCTTCCAGTTGATATTTATATCGGTGGAGCAGAGCACGCTGTACTTCACTTACTATATGCTCGTTTCTGGCATAAAGTATTATATGATATCGGTGTAGTTCCAACGAAAGAACCGTTCCAACAATTATTCAACCAAGGTATGATCTTAGGTGAAAACAACGAGAAAATGAGTAAATCAAAAGGTAACGTTGTAAATCCTGATGATATCGTAGCAAGCCACGGTGCAGATACACTTCGTCTATACGAAATGTTCATGGGACCATTAGATGCTTCAATCGCTTGGTCTGAAAATGGTCTTGACGGAGCTCGTCGTTTCCTAGATCGCGTATGGCGCCTATTCATTCAAGATAACGGTGAATTAAGTGAGAAAATTACTGATGCACCAAACAAAGATCTTGAAAAAGCTTACCACCAAACAGTGAAGAAAGTAACAGAAGACTATGCAGAGCTTCGCTTCAACACAGCGATTTCTCAAATGATGGTATTCATCAACGATGCATACAAAGCTGAAACACTTCCGAAAGAATATGTAGAAGGTTTCGTAAAAATGATTGCACCAGTTGCACCTCACATCGGGGAAGAACTATGGAGCAAGCTTGGATACAATGAAACAATCACATATGCAAGCTGGCCAACATTTGATGAGTCTAAACTTGTAGAAGATGAAGTTGAAATCGTTGTTCAAATTATGGGCAAAGTTCGCGCAAAATTAACAATGAGTAAAGACGCATCAAAAGAAGAAATGGAACAACTTGCACTTGAGGAAATCAAAGAACAAATTGAAGGGAAAACAGTTCGTAAAGTAATTGTTGTTCCTGGAAAACTTGTTAACGTTGTTGCAAACTAATTAATTATTAATAAAAGCTCAGAGCGTTTATGCTCTGAGCTTTTTTGCGTGAAAAATAAGCTCAGGATCACCTTCATCTAAGTTTTCGATCATTCCACTACGCATAAATCCATTTGCTTTAAAAACTTTTTGCATATTTGTATTCGATTTGTTCGTTGAAGAAAATATTTTTTGAGTAGGAGAATGTCTTAACATATATGAGATTAATGAGCTTGCATGACCTTGTCTTCTTTTCGTTGGCGAAACAATGATTAATGAGAGGAAAGTATGACCAAAGAAATTTGTATCGTATGTTAGAAAACCAAAAATGGAATTGTCCTCTTTTGCAATTATGCAGTTTCCTTCATCAATAGCGTGTTTAATATAATCTCGTCTACTATCGTCTCCGATTACATCAACATCTATATGTAAGATTGAATCTAAATCGTCGATGGAAGCTTTTGCTATGTTTTCCAATGGAAATGCCCCCTTTCAAGTGAAAGAAAAATAATCAGTCAATTAATCCTATCATGAATGGAGAACGAAGAAAAAGGTGCGGAATTCCTATATAGACAAACACCTATTCTTCTATAGGAAATATGATAAAAAAGGTAGGTTAAATTGAGCAGAAGAGGTGAAAGGAATGAAAGGGATGGGCAATAATGCACCACATGGCTTCTTCGGAGGTGGATCGGATAGTTATGGACAAATGATGTTTATGGGAGGAGATGGTCAACACGGATATGGCGGAATCCCAAGTTGGATGGGAGGAGCAGCTGGAGGATTTCCGACGTCAGTGGCGGGTGTACAAACAGGATTCCCAACATCAGTAGCTGGAGTGCAAACAGGATTTCCGGCAGTAGTAGGAGGTACACAAGGAGGAGTGCCTGTAGGTATGCCAACTACATTTCCATCTTTCGTTGGCGGTGTACAAACAGGATTTCCTGTACCTGGCGTTGGTGTTGTAGCTGGTGGAATCGGCGGATTCCCTCAAGGTGTTCACGGTCATCATGAGCATCACGGCCATCATCATCATCATCAACACGGTCATCATCAGCACCACGGTCATCATCAGCATCATGGCCATCATCAAATTCATCCGCAGGCTGTCCTTTATCAAACACACCAAGGCCACCATCAGCACCAAGGCCACCATCAGCACCACGGTCACCATCAGCACCAAGGTCATCAAGATCATCACGGCCACCATCAGCAACAAGTACATCACCAAGGCCACCACCAAATTCATCCGCAAGCTGTTCTTTTCCAAACACACCAAGGCCAACACCATCACCAAGGCCAACATCATCACCAAGGCCAACACCATCACCAAGGCCAACATCATCACCAGGGCCAACACCATCATCAAGGTCAACACCATCATCAAGGTCAACACCATCATCAAGGTCAACAGCATCATCAAGGTCAACAGCATCATCAAGATCAACACCATCATCAAGGTCAACAGTATCATCAAGGTCAACAACAATACCAACAGTATCAGCAGCAACAACAGCCTTGGGCAGGTGGAATTGGAGCAGGAACGGCAGCAGGAGCAGCAGCTGGTACTGCAGGAGCAGCAGGACACGCGGGACACGTGGGTCATTAATAGACCAAAGGAAAAAAGACATAATAAAAAACTGCTAGGAGATCCTAGCAGTTTTTTTCTGCCTCTTGACGTTGGCGTTCGATTTCCGCACGAAGTTGTGGTTCTGGTGCTTGCCATCTTTCTGGTTTCATAATTTTGCCGTCGCCCTCGCGGAATCGAGGCTTTCCATCAGGGAATAGTTTTGCCATGTTAGCATTGTTTACAATTTCGAATCCTTTATCTGGACGTACGCCCATTTCTGCAAACGTTCCGAATGCAAAGTAAATAAGGTCAATAAGTGCATCATATTGATCTTCAACAGTTGTTGCTTCTAGAAATTCTTCTAGCTCTTCTTGCATAAAGCTAGCACGAATTTTTGCACGCTTTTCTGTTAGTTTTGTTGGAGTACTTGTCACAGGATGTCCGAATTCTTCATGCATTTTTGCAACAAGTTCGTATCCTTTATCTAAACCTTTTTCGTTTGTCATGTTGTTTCATCCTTTCTTACGTTATGCCGAATTTTATCCCGCATTAACGGGCAGTAAGACTCCCACCTCAAAAGTCGCAAATGCGAGGAAGTGAGGTGGGAGATAACTGCCCGTAAAAGCCCGATTGGTTCAACTAATAATCAGTGGGGAATGGACAAAATCCCCACTGATTAAAGTTTCACTTTATTGTAACATAAGGTAGTTATTAAATAAAAAGAACATCTTATGAGAAATAAGATGTTCGCTCGTTATTCTTCTTTCTTAATTAAAACGGATAAAATAAGATCGATGCCAAACATTCCGATGAGTAGCATTGGTATAACTACAAGTAAATAACGTGTGAAAGAAACATTTTTTAAGTATGTATGAGCAAATAAAAAGACGCCGAGAAATAAAATACCATTTAAAATAGGTTTTACTAATTTTTTAGACATAAGCTCCCCCGTAAATATCCCTTTTCTCTATTTAAAAATAAAAACTCTCCTCTCCGTTGTACCATGCCAGAGAGGGGAGTTCAATCATTAACTTATTCAATTACACCAGAATTTGTAATATTGACAGTGTATGTCACCTTAATAGGAACATCTTTATACATTCTTCGCCACTCTTCTAATTTGAATGGACGGTAATGTTCTTTATACCTTGCGCCGAGACCGAGTGGATCCACATTCAAAGATTTAAACTGTTTAATTAGTTTATTAGCTTTTGCACCTAATTGTTTTTCAACTGATTTTTCTATTTTTTTTGTGTTCTTTTTATTTTCTAAGTTGAACTGTTTAGATAGTTCTTGAATACGTGCTTCTAGTTTGACGTGTATGAAAAATGATGGTTTACCATCTTTAATACTTACTTGGTAAGTTGGGACGGATCGAATATTATTAATGATTGTGTATCCTGAGTTTGCTTTAAATTCATGTGAATCTAATCGGTGTTTTTCCAATAAACCTTTAAAGGCAAACATATCATGATAACTAATTTTGCCAATATATTTATCTCCTTTTAAAAGGCCGATGCCAGTAATTTTTATTTTATCTTTATCTTTTTTGAGAATTGGTAAATAGGAATCTTGGCCTTCACGATAATATCGATAGGCTCCTAAATGTAGATTGTCAGTAGGTAAAGGACCCGTTTTCATATTATGGTCTAACATTTTCTTTATATAAATTGCAACGTTAGATGATGTTGTATATTTACCCTTTAGTAAGTCTAGCCCTGTTCCCTCTAATAAACCGACATACATAGAGTTCCCGATATTCACATCACGAATTAACGTGTCAAAGGAAGTTGACAACCCTTTTTTAGCAATTTTTGTAGTAAATAAAGCAATACGCATTTGTCCACTTGCAAACGGTTGAGCGGATTCTAAAGAAGTATCCGCTTTTACTTGTTTTACTGCGTTTCCTACGCCTTCAAAGACTTGAACTTTATTACCTTTTTTCTGTATAGGACATACGAATGTGACTTTTACTTTATTATCTTT
+>8_3#NODE_4_length_39999_cov_63.2942_ID_7
+AAGGTTTAAGAAGGGGCAATAGAATTATGAAATCAGGAAAGTATGAAGTTAGAGCTAAGGGCCATGGCGCAAGTTTCATGCCTATGGAAGTAACCCTCTCTGAAGATGAAATTGAAGATATTAAGGTAGATGCTAAGGGCGAAACTAAGGGTGTGGCAGATGAAGTCTTTAGACGCTTGCCAGAAGAAATTGTTAAAAATCAAACTTTAAATGTTGATACCGTTAGTGGTGCCACTATTTCTAGTCATGGTGTGATTGATGGAGTAGCCAGTGCAATTAGTAAAGCTGGTGGAGACCCTGATGAGTGGAAAAAACGTGCCAAGCCTGCAGAACAAAGAGAAAAAGACGAAACATATACTACTGACGTTGTAATTGTTGGTGCTGGTGGTGCAGGTCTAGCTGCAGCAGCAAGAAGCATTCAACATAATAAAAAGGTTATTGTGCTTGAAAAATTCCCACAAATTGGTGGTAATACCAGTCGTGCTGGTGGCCCAATGAATGCGGCTGAACCTGATTGGCAAAAACAATTTAAAGCTTTAGCTGGTGAAAAGGAAACTCTTGAAGAACTGGCAGCAACTCCAATTGAAAAAATTGATCCAGAATATCGAACAGATTTTAAGGAGTTACAAAAACAAATTAAAGAATATGTTGCTTCTGGAGCTAATTACTTATTCGACTCAAAATTACTTCATGAAATTCAAACTTATTTAGGTGGTAAACGTACAGATTTAAAGGGTAATGAAATTCATGGTAATTATACCTTAGTTAAAGAATTAGTTGATAATGCTTTAGATTCAGTTCACTGGTTGGCAGATTTAGGAGTAGTTTTTGATCGCAGCCAAGTAACAATGCCAGTTGGTGCCTTGTGGAGAAGAGGACACAAGCCGGTTGAGCCAATGGGCTATGCCTTTATTCATGTTTTAGGTGATTGGGTAAAAGAACATGGTGGCACAATTTTAACTGATACTCGTGCTAAGCATTTAATTATTGAAAACGGAAAAGTTTGTGGTGTAATTGCCAAAAAGCCTGATGGCAGTAAAATTACTATTCACGCCAAAGCAGTAATTTTAACTGCTGGAGGATTTGGCGCAAATACGCCAATGGTTCAAAAATATAATACTTATTGGAAACATATTGATGATAATATTGCGACTACTAATTCTCCAGCTATTACTGGTGACGGGATTGGTCTTGGTAAAGAAGCAGGTGCAGATTTAGTTGGAATGGGCTTTATTCAAATGATGCCTGTTTCTGATCCTAAGACTGGTGAACTATTTACTGGTCTTCAAACTCCTCCGGAAAACTATATTATGGTCAATCAAAAGGGAAAGCGTTTCGTAAATGAGTTTGCGGAACGTGACGTTTTAACTAAGGCAGCGATTGATAATGGTGGTTTATTCTACTTAATCGCTGATGACAAGATCAAAGATACTGCTTATAACACAACGCAAGAATCACTTGATGCTCAAGTTAAAGCAGGTACCTTATTTAGAGCAGATAGCTTAGAAGAGTTAGCTGAACAAATCGGTATGGATCCTGATACTTTAGTCGATACAATCAAGAAATATAATTCATATGTCGATGCAGGAAAAGATCCTGATTTTGAAAAGTCTGCCTTTAACTTAAAATGCGAGGTGGCACCATTTTATGCTACGCCAAGAAAGCCTGCTATTCATCATACAATGGGTGGTTTAAAGATTGATACTGGTGCACATGTTTTAGATAAAGATGGTAAACAAATTTCTGGTTTATATGCGGCTGGGGAAGTAGCTGGCGGAATACATGCTGGCAACCGTCTAGGAGGGAATTCTCTTGCTGATATCTTTACTTTTGGTAGAATTGCCGCAAACAGTGCTATTGATGAATTAGAAAAATAGTATAGATAGATTAAAACGTTGTAAACACTAGTATTTGCAATGTTTTTTTGCTAAAATACTAAAAATACCTAATTTTTTGGAGGACTTGAATTGAGAGAAGCGCAGGAAAAAAAGTTAACTACAAAGCAATACTTAATTGTAGCATCGATGATTTTTGCACTGTTTTTTGGTGCAGGAAACTTAATTTTCCCACTTCATTTAGGCCAGCTTGCTGGTAAAAACTGGGGACCAGCAGCAATTGGTTTTTCAATTACAGGAGTAGTCTTACCCTTACTTTCACTTCTTGCAGTTGCAATTACTCGCAGTAATGGTGTTTATCAAATCGGATTACCAGTAGGAAAGGTCTTTGCTCTTTCTTTTATGACTTTGATGCAGCTAGCAATTGGTCCTTTATTTGCAGCACCAAGAAATGCCACTGTATCTTATACTGTGGGGATTGCACCTCTTTTGCCTAAGCAATTTCATGGAATCGGTTTGATTGTCTTTACAATTATCTTTTTTGCCATAGTTTATGTGATTGCCTATAACGAGAGTGATATTCTTTCTTCTTTAGGTAAAATTCTGAATCCGATCTTTTTAATTTTACTTTTTGTTGTTTTTGTAATTGCGTTTGCTCGCCCACTTGGTAATCCTGAGATGGCCGCACCTACTAAAGAATATATGAACGGCGCAATAGTTAAGGGCTTTTTAGAGGGCTATAATACTATGGATGCTTTGGCAGGCTTAGCCTTTGGGGTAACTGTGGTAACAGCAATTAAAGAGCTAGTTAATAATGACAAAAAGAAAACTGCTAAAATGACTGCTAAGTCGGGGTTAATTGCAGTTTTTGCAATTGGTATAATCTATACTTTATTAATCGTTATTGGTGCGATGTCATTAGGGCATTTTAAAATAGCGAGTGACGGCGGTATTTTATTTTCAGAGCTCGTTAAGTATTATGCTGGTATTTTTGGACAGGCTTTGTTAGCTGTTTTAATCTTTTTAGCCTGTTTAACTACCGCAGTTGGAGTCTTAGCAGCTTTTGCCTTAGATTTCAGTGCCCACTATTCAAAGATTAGCTATAAAGGTTGGCTAACAATCGGTTGTTTAGGTTCTTTAGCTACAGCAAATTTAGGTTTAGAAAAGATCATTCACTGGTCACTTCCTGTTTTAATGTTTTTGTATCCCTTGGCTATTGTGTTAATTATTTTATCTGTATGTTCACCACTATTTAAAGGTGACATGGTAGTATACAAAATTACGATGCTTTTAACTCTAGTTCCAGCGATTTTCGATCTAATTACCAACTTGCCTGCACCAATTTCTGGAACGCAGTTTTATAAAGTAGTAAGTCAGATTCGCTTGCAATATCTACCTTTAGCTAATATTGGCTTATCTTGGGTTGTACCAACAATTTTAGGATTAGTTATCAGTGTCTTGATTCATTTTGGGCGTCGTAAAGCTAATAAAATATAGTAGTTCGGCTATGGTTCATTTGAATCATGGCTTTTTTGTTGGGATAATGAAATTAGGTGATAAAAAATGAGTTTAACCAATAAAGTGCTCGAAAAAGATGTGCATGATTTATTTACTCGGGTAGCGCCGCATTATGATCAGATGAATAATTTAATTAGCTTAGGTACACAAAAAAGCTGGCGCAAGAGATTTTTAAAAGAATTAAAAGTAGCACCGGGTGATTTTGCCCTAGATTTATGTTGCGGTACAGGCGATATTACGATTGCTTTGGCAAAACAAGTTGGTCCGTCAGGAAATGTAATTGGGCTTGATTTTAACCAAGAAATGCTTGATTTAGCTGAGCAGAAAATACGTCAGCAAAATTTACAAAAAGAAATTCAGTTAAAGCAAGGGGATGCAATGCATTTGCCTTACCCAGATCAGAGTTTTGATATTGTAACGATTGGCTTTGGCTTACGGAACGTTCCTGACGCAAATCAGGTCTTGAAAGAAATTTATCGAGTATTAAAGCCAACTGGTAAAGTTGGAGTATTAGAAACATCGCAGCCAACTAATCCGCTTATTAAGCTAGGGTGGAAGAGCTATTTTAGGCTGTTTCCTAGCTTTGCGAAATTACTAGGAGCCAATGTATCTGATTATCAATATTTGTCTCATACAACCGCTGAATTTGTTTCTGCGCAGCATTTAAAAGAAATGCTTGTAAAAAATGGATTTAAAAATGTGCAGGTAAATAAATTAAATCTAGGTGCGGGTGCAATTCATGTCGGAATTAAGAAGTAAATGAGCTAAAATATAAAATAAAAACTAAAAAAAGGAGAATTTTATGAAAACTGGTACTAAAATTATTACTTTAGACAACGGTTATCACTTGTGGACTAATACTCAAGGTGAAGGCGATATTCACTTATTAGCGCTTCATGGCGGACCTGGTGGCAATCACGAGTATTGGGAAGATGCTGCAGAGCAACTGAAGAAACAAGGATTGAATGTACAAGTTACAATGTATGATCAGTTAGGTTCATTATATTCAGATCAACCAGATTATTCTGATCCAGAAATCGCTAAAAAATATTTAACTTATGAATATTTCTTAGATGAAGTTGATGAAGTTCGTGAAAAACTTGGTCTAGATAATTTTTACTTAATTGGCCAAAGCTGGGGCGGTCTTTTAGTTCAAGAATACGCTGTTAAATATGGTAAGCACTTAAAGGGTGCAATTATTTCGTCAATGGTTGATGAAATTGATGAATATGTTGATTCAGTTAACAGAAGAAGACAAGAGGTTCTTCCACAAACTGAAATTGACTTTATGCACGAATGTGAAAAGAATAATGATTACGATAATCAACGCTATCAAGATGATGTGCAAATTTTAAATATTAATTTTGTGGATAGAAAGCAACCATCAAAGCTTTACCATTTAAAAGACTTAGGTGGCAGTGCAGTTTATAATGTCTTCCAAGGTGATAATGAATTTGTTATTACTGGTAAGCTTAAAGACTGGCATTTTAGAGATCAACTTAAGAATATTAAGGTACCAACATTAATTACTTTTGGTGAAAATGAAACAATGCCAATTTCTACTGCTACAATTATGCAAAAAGAAATTCCAAATTCCCGTCTTGTTACTACGCCTAACGGTGGACACCATCATATGGTTGATAATCCTGACGTTTATTATAAGCACTTAGCTGACTTCATTCGTGAAGTTGAAAATGGTAATTTTAAGGGTGAATAAAGATAAAAAGTCCATGCGATAGTTTCTATATTGAAGCTCTAGCATGGACTTTTTAAGCATATAAATCGCTTTCATGACATATATTCTATATAATTAATAACAAATATAGTTTTATTATTTTAAGGAGAAAAGCCATGAAGAGAAAAATAAGTAAACTACTTGCAGCGACGGCTTTAATGGGGACACTAGGAATTTCAGTAGTGGCTTGCGGCAATAATGATTCAACCAGTAAAACTAAACAGTCAAGTGTAAAGAAGACTGCTAAAGATAAGGCAAGTAATACAAAAAATGCAACAAGAAAAAGTCAGATTAAACTTAGTCAAACTGAAGCAATAAATAAGTTTGATAAAAAGTATTCTGATAAAAAATTAAAAGAAATAGATCTAAAATTAGATGGTAATAAATATCTTTATGAAATTACAGGATTTGATAAGGATAAAGAATATGAAATGACCATCAATGCCACAAGTGGAAAAGAAGTCAAATCTAGTTCCGAAAAATTAGACTTAGATGAACGTTTGCAAAAGGGACTTGATTTAGATAAAGTGATATCTCGTGATCAAGCAAGTGAAATAGCAGAAAAAGAAGTTAAAAATAGTACTGCTAAAGAATGGACTCTAAAAATGGATCAAGATAAAGCCATTTGGGATGTAACTGTTGAATCAGGTTCAAGCAAACATGAAGTAGAAATTGATGCTATTTCTAAGAAAGTTATTAAATCAGAAAAAGATGATTAAACAAAAAAATTCAGAGTTTTTAAGCTCTGAATTTTTTTATTAGTATTTTTATAGAAATTAATTTAATAGGTGATTAGCTTGTCAGCGTTCATCGTTTCATCGTCTAACTTATAAGTCTTTAATTCAAAATCATTTTCAAAGTTGCAGTAATAAGTCTTAGTAGCAGCAGAGTAGCAAGCGGTGTAGACAGTGTATTCATCGCTACCCAGTTTGTTAACTACGCTACCCTTAATCATCGCAACAGACTTTAAGATGTTAAAGAACTTAGCCACGTTAGCTTTTTCACCCTTAACAGTTGGGTAATTAACATTTAAGTAAGCTGCTTTAACAAAGCGATCTGCTGGAATGCTATCACCTGGTAAACCTAAGCTGCCAGTGCCAACGCCCCATGGAGCAACTTTTTGACCGTTCCAGCTTTGAGCTGTAGCATCATGTGGATCTAAACCAGTATAGTTGCCAAGGTTAGTAAGATGCCAGTTAAAGTCTGGACTGTTAGTTAAAACGCCAAGCTTATCATCGAAGACTTTCATTCCGTATTGTTTTGAAACTTCAACAATAATAGCTTCATCTTTGTCACTAATAATCCAGTGAAGAGGAGCAACTGCAAATGATGAGTTAAGAGCTTCATTAACTAAGTTAACGTTCTTTAAAGCTTCTTTTACATCGCTAACTTTAGTAAAGTTCTGGGTGACCCAGAGCATAATTTCGTAAGAAGCTAAATTGATTTTTCCATCAATTGGACCATCGCTAAATTTAGCAAAATGTGGGAAGTTTAGACCAGCAATTCCCAAACCATCTTCATTGAAACAATCAAAGTAAGAAGGATAGCCATCAACTACAATTCCCATACCGATAACGGCTTTTTTAGTAGTCGTATTATCTAAAAACTTATATGGAAGAGGATAGTTGCGTGGTGTGATAATTACACCTTCACCATAATCTTGTCCAACATCTAAGTTACGTCCAAAGTAGAGATTTCCTTGATCATCTGTAAATCTTAAACCAGTACACATTTTAAAATCCTCCTTAACTATTTAGCAGTAGTTTTAGCTTCTTGCTGAATGATGTATTTCTTTTGACTTCTCTTAATTTGAATAACGGCAAATACTAAGATGATGAAACCAATTGCTACAAAGGCAATCATGAAGTACCAAGCAACTGTAAAGCTGGCTTTTCCTTTAATAATTCCGAATAATGGAGCACCAATAGCATATCCAATTGCATAAGCTAAACCCACATATCCTAGCATTACACCTTGATCTCTTGAACCAAAGAGATCCTTGGCCATAAATGCAGGACCAGACATGTAGCTAAATACAGCTAAACCACAGAAAATAGCATAAGCAACACCTGCGATTTTACTTACGTGAGCACCATAAGGTTGAAAACTGATCAAAACCATCATTAAGATGGATAAAACATACATGCAGCCGGCATAAGTCATTGATTTGGCAGTACCAAATTTATCAAATAAGAAGCCACCGGAAACATTTCCAATTAAACAACCAACACCGTACATTGATCCAATGAGGCCAACATCTGTTAGTGAAAGCTTAGTATCAAGAAAGGCCGCATAATCTTCATTTAAGGAAGCTAGGCCTAAGCCAATAATTAGAAAACCAAGACTGAAAATCCAGAACCATTTCATTTGTAGAACTTGTTTACTAGTCCAGCCCTTAAATTCTTTCGCCTTGGCCAATTCTGCTTCTTTTTTGCTTTCAGCTAATTCAGCATCAGAAACGACGATTTCATCTTTCTTAGGAGTTCTAATAAAGCAAGCAATAACTATACCAATTACTAATAGAGCAACTGCGAAGATGAAAAATGGTGCCATTGAGGTCAAGTGACCTGTCTTAGTGTTACCAGTCATAAAGTGCTTTAAAATAGCTTGCGTTGCAGGTTGTAAGAAAATATTACCAATCGAACCACCGCAGAAAGCAATTCCTAAAGCAGCTCCACGTCCTTTTGCAGGGAACCAGTGGTTAATAACCCAAGGAACACCTTGGCCGGAATAAAAAGTTGAACCGATCATACAAATGATAGCAGCAATATAGAATCCTGGCAGTTTTGTGCTAATTCCAAAGATTATATAGGCAATAGCAGAAAGGCCAATACCGATTAAATACATAAGTCTGAAATTAACTTTCTCTAATGCTTTACCAATAAATGGCGAAGCAACTGAAGCAAAAACTGCCCCAAACGTAAAGATTAATGTATACGATGCTAAGGTAAAGTGAAAAGTATTAACTAACGGGTGGATAAACAAAGGTTGAATATTTTGAGCAATCCCATAAGGAATGGCTTGGGTTAACATACAAAGGAAAACCATAAAATATTTATAGCCTTTGCTAACGACTTTATCTTTAGTAGCGACATCAGTAGACATGTAATTACCTTCTTTCTAAACTAATTACTTATCTAAAATAATATTTGGTTTGCTGACGACAATATTTTTTTGCATTTGCTTAATTTTAATAGCTGCAAAAATTAATAATATAAAACCAATTGCTACAAAGAAAATAGTGCAGCACCAAGCAGTTGTGAAACTGGTAGCGCCTTTTATGACGCCAAATAGTGGGGCGCCAATTGCAAAACCAACAGCATAGGCCAGGCTAATGTAACCTAAGTTAACACCTTGAGCTTTTGCACCAAATAAACTTTTCGACATAAATGCAGGACCAGACATATAGCTAAAGACAGATAGACCACTTGTAAAGGCCCAACCCATACCAGCGTAGAAATTAATGCGATCGCCGTAAGGATGAAGGCTAATAAAGATCATCATTAGGATAGCTATAATTAACATTATTCCTGCATATGCCATTGATTTTGCTGTACCGAACTTATCAAATAAATAACCCCCAGAAATGTTTCCGATGATGCCAGCAAGTCCAAAGACTGAGCCAATTATTCCGACCTCAGTTAAGGATAATTTAGTATCAAGAAAGGCCGCATAGTCTTCATTTAATGAGGCTAGGCCTAAACCGATAATTAAAAATCCAATGCTGAAAATCCAGAACCATTTCATGTGTAGAACTTGTTTGCCACTCCAGCCTTGAAATTCATGGGCTTGCTTTTGAGCAGCTTCGTGTCGGTTTTGTTCAACTTCTTGAGCAGAAGCTAAAATTTCATCTTTCTTTGGTACCCTAATAAAAGCTGCAATAATCAATCCAACTACTAATAGAGCAACAGCAAAAATAAAGAAAGGTGTCATCGAAGTTAAATGACCAGTCTTGGTATTACCAGTCATGAAATGCTTTAAAATTTCCTGGGTAATAGGTTGCAAGAAAATATCACCAATCGATCCACCACAAAATGCTAGACCTAAAGCAACACCGCGTCCTTTAAATGGAAACCAGTGATTGATAATCCAAGGGACACCCTGACCAGAATAAAAGGTTGAACCAACCATACAAATAATTCCAGCCAAATAAAAGCTAGGTAGCTTTGTACTAATTCCAAAAATTACATATGCTCCAGCTGAAAGACAAATACCTATCAGATATAAAATCTTAAAGTTTACTTTTTGCAAAGCCTTACCAACTAATGGTGAAACTAAAGACCCTACAACAGCCCCAAAGGTAAAAATTAATGTATAAGAAGCTAATGTAAAATGAAAAGTATTAACCAGAGGGTGAACAAATAAAGGCTGAATTAATTGGGCGATTCCATATGGAACAGCTTGAGTTAACATGCAGAGAAATACCATAAAGTATTTGTAGCCTCGACTGACCACCTTTTGTCTATCGTTTGACATCGTATCTCTCTTCTTTCTGACAAAATACTATTAGCTTGATAAGTTATATATTATTAAACACGTGAGCTTTGACTATAGCCACCTTTATTGTGGCTCACTAAATCGAGTAAATCAAAAAATAACGACCTATAATGTTATTTAATAGGCATAATAAAAAGCCTATCTTTTTGAGATAGACTTTAGAAAATTATTTTTTTACATATCCTGCGATGTCATCATCGTCAAAATCATAGGTTAACTTCTTATCATATGCTTTTTCATATGCTTTTTTCTTTTGTAGATAATCAATATCACGCATTCTTTTGGCATTTTGATCAACTGTTAGACGGTCAACTGGATAAATTGTTGGTAAAACGTGAAGAATGTAGCGAGTTTTGTGGAATTCGCTGCTATTTTTCTCCATTTCAGGGAGGTCCTGAATTTCTACAAAACAGGAAATAATTGGAACGTTGGCCTTAGCTGCGTAGTAGTAGGCGCCCTTTTGAAGAGGGCGAGGTTTTCGATAGTTATACCACATTTCTTGCTCCGGATAGATCAAGACCCAGCCCTTTTTATCAAAGACTTTTTGCAAATGCTTAGGAAATTCACGCCCCAAATATTGGTAGCTTTGAACAATTGGAATTGCATTAATGTTGTTCATTAGAAAACCAAAGAAACCGGGTAATTTTAAATTAGAATCTTCAATCACAACATAAAGTTTTTTGTGACATTTGTTGGCTAATTTCTTGATTGGAAGACTATCGGTTTGCTTGAAGTGATTACTGGTAATAATTGCGCCATATTTAGGTCCTTGAGCCCGCTTCTTATTTTTGATTTGCGTGTGAGCCATCAAAATTAAAGTGTCAATATTAATAATACCTTGAGCAATAATATTCTTTAGTTTATGACTAAACTTCTTTTGTTGTTTCCAATAATCGTTAACGAGTTTGATTCTTTCGCTTTTAGTCAGGATAGGATCGCCTAATTCGACTTTGGCATGCATTTTTCCCTTTTTAACGGCTGTTTTGATGTTTTCGATAACTTGCGCGCGATTTTCACCAATAATCATAATTTCACCCTTTCGCCTTTTCTTTTAATTTGAGCCCAGTTATTTGGATCAAGTGCCGTGCTCGCCTCTTTTTCAAGCATATGATCTAATTTTGCCCGATTTTCAGCTCGCTCTTGATTAGTATAGTTGTCTAACTCTGATTTTAATTCCTCATAAAAAGGTGTGCTAGAGGCATATTTCCAGAAATAATCATTATATTGGACGTCTTTAAAGTGCCAAGGTTTGAAAAATAAATTATAGTGAATTAGCCCTGGTTCAGGAATGGGGGCGGTATTTTCATTAGGCATTGCGTCCCAACGTGGATCAAGATGTAAAATTCTTCCGTCACAAATCTCATTTAGGTAGTCTTGATCAGGAGCAATACAATCAAAGTGATATTGCTCAAGTAAATGCATAAAGTGATCGATAAAGTGTTCATCCCTAAAAGCTTTAGAATTTAAGACTAACATCCCAGAATTAATATATTTCTTTGGATCGAGAGCTAGAACTTCTTTAATATATTTCACCATTTTATCTACATATTGAATCGATGAATCTGTACAAGCGGCGAATAGATTATTACCTAAGTCGTTATTATACAGTTTAGCAATGTCATCAACGACGACTGTGTCACTATCAATGTAGATTGCTTTATCATATTGTGGAAATAAGTCAGGGATAAAGAGACGATAAAAAATAGACATTGTGAAAAAGTCTGCCCGGAGATAGTTTTCTTTACGATTTTGGATCGGTTTTACCAGTTTTTCATCAATATGGAAAAATTTAACGTGCACATGGTCATTAGCAAAAGCTGCAAGTTGCTTTTGGTGTTTTTCAGACAGGTCTTGATTTAGAAAAGTAACTGTGTAATCTTTTTGCGGATTAGCATTTTTAACCAAGGAGTTTAGCGAAACTGCCGCATACTTGGCAAAATCATCACTAATACTATAAAAAACAGGGATAGTCATTTTTAAGCCTCTTTATATTTTTACAGATGTCGTTTTCTTAACTTTCGCCCAAGTTACATCTTCATCTTTGATTTCATCAACTTTTTTAATCATCCAATCAAGGTCGGCACGTGCTTTTTTACGGTCTTCATCGGTGAAGTTAGCTAATTGTTCTTTTAGTTCTCCATAATATGGAGACTTTTTAGCAACATCCCAGAAGTATTTGACATATTGAACATCTGCGAAATGCCAAGGCTTAAAAAAGAGATTATAATGGACAATTTTAGGATTTTTAATTTCATCCATGTGTTCATTGGGCATTGCATCCCACTCAAGGGGCAAATGATAAATTTTGTCTTCACAAATTTCGTTCATATAAGCTTGATCAGGATCGATATTATCGAAATGATACTTTTCAATTAATGAATAGAATTTATCAACAAATTTCTTATCTCTAAAGGCTTTCATATTGAAGAGAATAACGCCGTTATTGATATATTTTTCTGGTGGAAAAATACCTTGGCATTCCTTGATATAAACTTGAAGTGGCTTAATAAATCTGATTGACATGTCTGGTACACTAGCAAACATGTTGTCGCCGATTTCGGTGTTGTAGAGTTCAGCAATGTCAGTACAAATAATAGTATCAGCGTCTAAATAAACAGCCTTATCATACTGAGGAAAAAGGTTAGGGATAAATAAACGGTAGAAAATAGACATCGTGAAAAATTGTGCTCGTAAGTAATTCTCTTCACTGTTGTGAATCGGAGCTACCATTTCATCATCAATATGAAAAATATTAACATGGACATTTTTAGTAGAAAGATCTTCTAAATCTTTTTTGTGCTTATCGCTAATGTTTTGAACTAAAAGAGTAATGGTATAGTCTTTGTTTTGATCCACATGGTCAATTAGTGACTGAATTGAAACGGCCGCGTAGGGTGTGTAGTTGTCGCTAATTGTGTAAAAAACAGGTATAGTCATCAAAAAATAAACTCCTTATATATTAAATGTTTCTAGGCCCGCTTTAATTGTGACCTAAGCTCTACGTACTGCTTAAGTAAATCATCATATTCATGTAATTTCAAGACGCTGTGCACTCGCTCTATATCCCATGGTTTAACAGTTAAAGTATGGAAGTATGGCTTAAAACGAAAGCTAGTCGTGAAATGTTGAATTTTGGTATCTGGTCGTAAACGATATTGTTCATTGTAGCAACGTGGAGCAATTTTCTTCTCAGTAGCAAGTTTATTTAGAGCAGACTGATCTGGAAGAAGCATTTTTTTATCACTCATTTTTTCTCTTACTTTGGCAAATAATTGTGTTTTTTTAATTTCAGCCATGTTAAGAAGCAAGACGCCGGAGTTTAGGTAATCAAAAGTCTTGTGGGTATGGATATTGTGAAAGAAGAACCGACCCCAGAAGTCTAAAACACCGACTAGTTCAATATTAGCTAGATCTTGATTATAAAAGTCGCTAATATCTTTACGCACAATAATATCATCGTCTAAATATAAGATACGATCAGGAATCTGTGGTAGTTGGTCCGCAAAGAGACGCAGCATTGCATATGGCGTAAAACGAGTTTCCATATTTGCGCGTGGAGGTTCTTTTTTAAATAATTCAGTACAATCGATTAATTCAGCAGTATTGTTAGGATCCTTTTCTTTAAGCAATTTTTTAATTAGATTAAAAGCTTGTTGGTTAAAAGCTGTGTATCCCTCTGCGTGCATCGTCAAAATATAAAAGTGCAGGGGAGTTGATGTGTTTTTTAGTAAAGACAGCGTTGTAATTAAAATACCATCTTCGGCATGAGAATCGCCGCAAAACATAATATTCATTTTTGTCCTCCAATTTTTCGCTGCTGGTAGCGATAATATTCACAGTTACTCAATTTTGAACGGTTCTTCAATTGAGTAAATATTTGATCATGTAGCTTTTTTTGTTGCAGTTTTTTAGGTAGAGAAGTATCTGGAAAAAAGGGGCCATCAATATAAACAGTAATTCTAGGGTGCTTGCTATATTTTCTTTTCTGGTAGGTCGTTGTCATAACAAAGCTTGGCTTAGTTGTTTGAACTGGAAAGTTAAAACTAGTTGCTGGAAATGGACGAATATCAGTATAGTAGGGCCAAACATGAGCTTCTGGATAGATAATGATATGGGCGTTTTCCTTAATTAGAGTATTAACTGCTTTAAGCAGATGAATTGCTTGCTTAATATTTTTGCCAACTGGTAATCCTCCATAAGGCAAGAGAATTTTGCCAATTATTGGAATTCCCCAGTTTGCTTGATTAGCAATTGCATAATAATCTTTCCAGCCAAAGAGGGTTAAAGGCATAAAGACGTCGTTAACCATTTGAGTGTGATTTGCATAGACAAAATAGCCCTGATGCTTATATTTAAATAACTTATCTCTCCCTATTACTTTGACATGCATTCCGCCATAAGTAAAAAGATAAGCAAAGCCAGTAGCTAAAAAACGCATTAAATAGTTAAGAGGTGTGCGTTTAATTATTTGATAATCGCTAGGTAAGGTAAAATCTTGTTGCTTACTTTTGACAATGTCGTCAGTTAAAGAATTATAGTAAATAACATTACGTTGAGATGGTTTAGTATTCATGATATTAATTATAAAAGAAGTTTAAAAACAAAAAAAGACATCGCTTCAGCGATGTCTTATAAAATATGGGTGGTCAGGGGATCGAACCCTGGACCCACGGATTAAGAGTCCGTTGCTCTGCCAGCTGAGCTAACCACCCAATTGGATAACCAACAAATAGTATTATGCCAGGAAAAGAACTAAAGTGCAAGCTTTTTTTGCATAAGTTTAAAAAAAGTGTGGAAAACAGTATAATATAGTTATTAATATTGAGGAGGCATCATTTATGCCAAAAAAGATTTTAGTCGTTGACGATGAAAAACCAATTTCTGACATTATTAAATTTAACTTGACTAAGGAAGGCTTTGATGTCGACACTGCTTATGACGGCGAAGAAGCGGTTAAAAAAGTTGATGAATATGATCCAGACTTGATGATTCTAGATCTAATGTTGCCTAAAAAAGATGGCCTAGAAGTTGCACGGGAAGTACGTCAAACTCACGATATGCCAATTATTATGGTAACTGCGAAAGATACTGAAATTGATAAGGTATTAGGACTCGAGATGGGTGCAGATGACTATGTTACTAAGCCTTTCTCTAATCGAGAACTAGTTGCTAGAGTAAAGGCAAACCTACGTAGACGTGATTTAACCCAAAAAGCTACTGAAGATGATGAAGATAAAAATATTACTATTAGCAATTTGGTAATTATGCCTGAAGCCTATATGGTCGAAAAAAATGGCGAAAAAATTGAATTAACACATCGTGAATTTGAATTACTTCATTATTTAGCTCAGCATATGGGTCAAGTGATGACTAGGGAACACTTGCTGCAAACCGTTTGGGGCTATGATTACTTCGGGGATGTTAGAACTGTTGACGTAACTGTTAGACGTTTACGTGAAAAAATCGAAGATAATCCGAGTTCGCCAACAATTTTAGTTACACGGCGTGGAGTAGGATATTACGTTAAAAACCCATCAGATGAATAAGGATCAAAGTCACTAGTAATAGTGGCTTTTTTTGCAATTAGGACAAATGAAGAAAATAAAAAGTGTATTAAATTCTATCAATTTTAAAATCGCAGTAATTTTTATGCTGCTTTTATTAGCAACGATTGAAGTGGTTGGTGCGTCTTTTACAAGGCAACTCGAACAAAACTCAATTCAAAATTTTGAATCATCAATTCAAGTTCCAAATATTATTACTAACCAAATTTCTAGCCAATTAAGTAGGGCTAATTCTAAAAAGGCTAATCAGCAGTTAAGCCAGATTATCTCAAACTATAATTTGGGCGATATTAGCCAATTAATGGTAGTTGATAATAAGGGAGTAATTAGAGCTGTTTCAAATGTGAATGATCAAAACCGTATTGGACAGCGAACTAGTAATGTAGATATCAAGAGTGTACTCTCAAATGGAAAGCAAGTTTCAAAAGTTATTAATGACAATGGAAATTATATGGTGCAAATTTCACCTTTGACTTCTGCTAATGGAACTAATACTCCAGTAGGAGCAATTTATGTTCGCGCTAGCTTACAAGGTGTCTTTAATAACTTGAGACAGGTATCGATTTACTTCCTGATTGCTTCGCTGATTGCAGCTGTTTTGGGAGCAATTGTAGCCTTGGTTATTTCCCGGGCAATAACTAGACCTATTGAAGAGATGCGTAAACAAGCATTAAGAGTTGCAAATGGAGACTATTCTGGGCATGTTAGAGTTTATGCGCAAGATGAGTTAGGTCAACTAGCCGAGGCTTTCAATACTTTATCAGTAAGAATTGAAAGAACTCAAGAAATTTCAGACAGTGAGCGAAGACGACTAGATAATGTCTTAACACACATGACAGATGGTGTTATTGCAACAGACAGACATGGAAATATCACAATTATTAATGAAACAGCACTCGATTTTCTAGGAAAAACTGAAAAAGACGTTATTGGAAAGCCAATAACTAATTTACTTGGATTAAAAGATGTTACTATTCAGGACTTATTAAGTACTCAGCAAGAATTAGTTGTTCGAGTTAATGATAATACGCGCGATGAAATGATTTTGCATGCTAACTTTTCTTTGATCCAGCGTGTAACGGGGTTTGTTTCCGGCTTAGTTTGCGTGCTTCATGACATTACCCAACAACAAAAAAATGAACGTGAACAACAACAATTCGTTTCAAATGTTTCACATGAGCTTAGGACGCCGTTAACAAGTTTAAGAGCATATGTTGAGGCATTGAATGATGGGGCATGGAAAGATCCAAATATTGCACCACAATTTCTGCATGTTATTCAAGATGAAACTGAGCGAATGATTCGAATGATCAATGATTTGCTTAGCTTATCTAGAATGGATCGAGGAGTAGCGAGGATGGATTTAGAATGGGTTAACTTAAATGACTTTGTTAACCACGTTTTAAATCGTTTTGATATGATGCTCAAGTCTGATTCTGATAAGATGCACAAAAAGAAATATACGATTAAGCGTGAATTTCCTCATCAAGCCTTATGGGTTGAAATTGATACTGACAAGATGATGCAAGTAATTGACAATATCATGAACAATGCTATCAAGTATTCACCTGACGGTGGCGTCATCACAGTTCGCCTATTGCAGGCTCAAAAGCACGTTATCTTAAGTATTTCTGATCAAGGATTAGGAATTCCAAGAAAAGATTTAAACAAAATCTTTGATAGATTTTATCGTGTTGATAAGGCGCGTTCTCGTAAACAAGGTGGAACTGGTCTAGGACTGGCTATTTCTAAAGAAATAGTAGAAGCACACCATGGTCGAATTTGGGCAGATAGTGCTGAAGGAGCCGGCTCAACTTTCTACATTTCTTTGCCATATGAAGCAATTAGCGAGGAAGGAGAAAACTGGGATGAGGTTTAAAGATAAGTTTTCTAGAATTGCATTACGAGTTAGCTTAATTGCAATGGTTGCACTATCAATTATCTTGTCAGCTATTATTTGGGGTTCTGATGCACGATTCTCAAGGATTGAAGAGACATCTAATCAAACTCAAATTAAAGATTTAGGCCAACGTTCTTTAAGAGATATTTATTTACCTACTCAAACTTTTTATTTTAAAGATAAGCAAATGTATCAGGTTTACGATACTAAAAATAATCTTCCGCTAGAGTTTTCAAAATTAACTCAATCAGTTAAGCCACTATTGCCAATCAGAGTTTGGTCTAGTCAAAGTAAATATGAAAAGTTATTAAAAAATCCTGACTATGTTCAGTTAACATATCCGGATCAGATAACGATTTCCTTATTCTTAACTAATGTAAGAAAAACTGATAGTCGGGAATTTAATCGCTTTTTTGTGCCAGCTCGATCCAGTAAGTATATTTATTTAGGCAATGACGAAAACTATACTATTTATCGAGTTCGTCTAAATGATGTATCGTTTGACAATTTGGTGGAACATATTCAAAGCGCTAAAACACAGATGCCAGTTACGCTTCAAAAAGTTCATGATGATTATTTACTTTTCTATGAAAAGGATTTAAGTTTACCAACATACAGCTATTTAACTAATGAAGAGTCAGATTCATACTTTGTGTATCGCTTGTTAGGCTCTAATAATCCTACCCAGCATAGTTCTGGCGAAAGCATTACATATTCTAATGGAGTATACGAGCGGTTGATTGCGGCAAAACATACTCATAATTATGAATATGTTGATTATCAACAGGATCAGGTTCCGAAGACTATTAGTCGAAAATTAAATGATAGTTTATATTTTGTTCGTAAAATTGGATTATCTGAGCCAGATTTAAGGTTCTTTGATGCTGATAATAATACAGTTATTTATCAAAATTATGTTGAAGAATATCCGATCTTTTTACCAGGGAAATATAAGATGCGGGCGCAAGTTAAGTTTGCTTCTAATGGAATGACAATTAACTTTAATAGCTTAGACTTGCAGATTCCAATTCCAACTAATGGTGAAAAGAAGACGCTTATTCCGACTAATGAAGCGATGGATGAATTATATCAAAAGGGATATCACCAAAAAGATATTGAGCGCATTGTTATTGGCTATACAGCTAAGTCTGATAATAGTAAAAATAAAAAATTAGTAGATCTAGAACCAGCCTATTATGTAAAGATTAATAAGCAGTGGAAGACCCTAGATGAATGGCTAAATATTAATAATCAAATTACAAATTCTAGAAAGGAGGGGCTAGTAGATGGACTTTAAGAGAATTGAATGGATTTTTTTAGTCGTATTTATTGGAATTAATATCTTTTTGGGTATTGAGCTTTGGCAAACACCGACGCTTTTATCTGCTGGCTCTACTCCAATTCAAACTGATATTAAAAGCGAAACGAGTGCAGATCAGATAACTATCCCTAAAGTTGATGATAAGCAAGATGATGGGTATTATTTAGCTACCAAAGTGGACAATTCTTGGACAAAAAAAGCAGCAGCACAGGTAAATCAACAAGTAGAAACTAATACAAGTGAAAATAGTATTTCAGTTAATTTGAACAAACCAATTACTCTGTCGAAAGATTCCAAAAAAGCCCTGAAAGAAATTATTCACTTTAAAAATAATAGTCAAAACGTGTATGAGGGTAAAGATTATGTCTATCTTTCAGAATTATCCGAGGGAGATGATTATGTCTTTAATCAGAAAACAAAGTATGGAGAAGTTTTTGCAGCAACTGCTCTATTGCACATTATTGTTAAAAATAATCAAATTGTATCGTATTCGCAACGCTACGTTAGCAATTTGAATCCAGTACGTGAAAGACAAAATACAATTAGTTCAAAGGCTGCTGTAAATTCTTTATACACTTATAGTGAATTGCCAAATAATTCTAAGATTATCTGGTTAAAGCAAGTTTATACTAAATTGATCACTGTTCGAGGGAGCGAAATTTATATTCCTACATGGGTAGCTGCGATTGAAAACAATAATTCTCATACGATGACCCTTAAGCGCGTAAACGCATTTACAGGGACAATTATCCAAAATAATATTGCTGCTGATGATTCAAAGGAGTAGAGAAATTTGAAAGTATCAGTTTTATCAAGTGGTTCAACAGGTAATTCTACATTGATTGAGACTCCGCAGCATAAAATCTTAATGGATGCAGGTTTATCTGGAAAGAAAACTAAGGAATTACTAGCACAGGTAGGCGTTGATATTAAAGATATTGATATGGTATTTATTAGCCATGATCATACTGACCATTCTGGTGGATTAGGCGTATTGATGAGAAGATATCCTAAAATTTCAGCCTATGCGAATTCAGGTACTTGGAATTATTTAATTGAAAGCAATAAGATCGGTAAATTACCTGTTGAACAAATTAATACGTTTGAGTCTGGTATAACTAAGACTTTTGGTGATTTGGACGTGACAAGTTTTGCGACGAGTCATGATGCGGCGCAGCCACAATATTATGTCTTTACAAGTGGTGGGAAAAGATTTGCGTGTTTAACAGATACTGGTTATGTTTCAAGTACTGTTAAAGGTGAAATAAAGGATGCAGATGGCTATTTAATGGAATTTAACTATGACGATATGATGCTTAGAAATGGCCCTTATTCTTGGTCTTTGAAACATCGAATTATGTCTGATGTTGGACATCTTTCAAATGATCAAGCAGCAGACACCTTACTTGATGTAGTTTCTCCCAAAACTAAACATATTTTTTTAGCGCATCGCAGCCAGCATAATAATACTCAGTATTTAGCGCATGAAACGGCTGAAGACTTATTGGTAGCTGGGGATGCAAATTTACCAGCTGATGTTAAAATTATTGATACTAATCCAATGCAAGCTGGTTCTTTAACGAAAATATAAATTTTTAGCAAATAATTTGACTTGAATTCATAAAAAATTCAAAATTTGTGATTAGGCTAGAAATGAAGAGAAAAGGAGAAATTTTTATGGCAGAAAATAATACTAAACACCCTACTAAGCATAATGCTTTAATTAAAACTGGTATTGTTGGAGTGGTTGCCGGACTTCTTGGGGGTGGAGTTGCTTATGCAGGTTTGTCTCAAGTTAATGGGCAAAATGCACCACAAACAAGTGTTGTTCCAACGACAAAAGTTGAAAAGTCTAGCAGTAAAAATAGTAGCCAGATGACTAATGCCTTTAATACGGTAAAGAAATCAGTTGTTTCTGTTGTTAACTTAAAGAGACAAAGTTCATCTTCAAGTAGTGATCCGTTTGGTATTTTTGGCTCTGACAGTTCTAGTTCTTCAAAGAAAAATTCTAAGTCTGATTTGGAAACTTACAGCGAAGGTTCAGGTGTTATTTACATGAAGTCTAATGGCAAAGGCTACATTGTAACTAATAACCACGTTGTATCTGGAAGTGATGAGATTCAGGTCATTTTAAGCAATGGTAAAAAGGTAACTGCAAAAAAAGTAGGAACTGATTCAGAAACAGATTTAGCTGTTTTAACCATTGATGGAAAATATGTTACTCAAACTGCGCAATTTGGCTCATCTAAGAATTTAGAGCCAGGACAGCAAGTTATTGCTGTTGGTTCACCTTTAGGTAGTGAATATGCTACAAGTGTAACTCAAGGTATTATTTCAGCTAAGAATAGAACTGTTGATGTAACTAATTCTGCTGGACAGGTTACTAACCAGGCAACCGTTATCCAGACTGATGCTGCTATTAATCCGGGTAACTCAGGTGGTCCACTTGTGAATATGTCTGGTCAAGTAATTGGGATTAACTCAATGAAATTATCCTCTTCTAGTGATGGTACAGCTGTTGAGGGAATGGGATTTGCAATTCCAAGTGATGAAGTTGTTTCTATTATTAATCAATTAGTTAAGAATGGAAAAATCATTCGTCCAAAATTAGGTGTAAGAATTGTATCAGTTGACGAATTAACAGAGTATGGCCGCAAGAAACTTGGTTTGCCTGATAGTGTTAAATCTGGTGTCTATGTAGCTAGCGTTACTAAGAATGGTAGTGCAGATAAAGTAGGAATTAAGTCACATGATGTAATCACCAAGATTGATGGTAAAGATGTTGATAGTGTTGTTTCACTACATACTGCGCTTTATACACATAAAGTTGGTGATACAGTAACACTTCAAGTCGTTAGAGACGGTAAGTCACAGAATATCAAAGTTACTTTAAGTTAAGTGAATATTATTAAATAGAGATAAAAAAGCTATGATTATGCGTTTTGTAAGCGGTGATCATAGCTTTTTCTTAATATTTAAAATGTGAAACGTAATAAAGTTCGTCTTTTTGAATTGTCAAGAACTGAAAGTTATCCAGAAGATTGTGGGAAAATGTGGAAAACTCTGTGGATTGTGCATAACTCGGTCAAAGTAAAAATAAATAGTGTGGAAAACCTGTGAATTGTGTGTAAATAAAATTCTAAAATTAGCTGTTCTGAACGGCTGTTCAAGTTGATTATGTAGGGAATAGACCCAAAAGTTTGGAAAATTAGTAGTATTTATAAAAATGTGGAATAAATTTGCTAAAAAAGTTATCCACTTTTTTAGAAACCACAATTTATTGATAATTAATTAAGTCAACCACTAAATATAGTTTTCGATAATCCACAGCTAGGGGAAAAGTGATGTGGACGCTATGTCAATTAGGGGATAAAATTAAAAACTAGATGCGTGAAAGGTTAGATAGTTACAATGAATATCAAAATTGTTTGTGTAGGTAAACTAAAAGAAAAGTATTTTAAGGATGGTATTGCTGAATACGTAAAGAGAATGGGGCGTTTTGCTAAAGTAAAAATAATTCAAGTACCAGACGAAAAAGCCCCCGAAAAGCTAAGTCCTGCTGAAATGGAGCAGGTCAAAGAAATCGAGGGAAAAAGAATTCTAGATAAGATAAAAGATAAAGAATATGTTTATGTAACGGCAATTAAGGGTAAAGAAAGAACTAGCGAAGACTTTGCTAAAGAGCTAGCTGACTTAACTACTTATGGACATTCAGACATTACCTTTGTGATTGGAGGAAGTTTAGGAACAAGTAATGCAGTAAACAAACGAGCTGATGATCTAATTAGTTTTGGTAAATTTACAATGCCGCACCAATTAATGCGGTTAGTTTTAGTTGAACAAATTTACCGTGCCTTTATGATTAATAGCGGTAGTCCGTATCATAAATAATTATTTTATAAAAAATAAGATTGGTTGCAGTAGGATTAAAATACTACTAAAAATAAGCCAGTCTTTTTTTGTTAGGGCAATTGGCACGATGACATTTCGTGGTTTATCTTCACGATACCCATGTGAAATCATTCCTTCAGCAAGGCTGTTTGACCAAGAAATAGCTGCTAAAATCGCTTTAAAATATAATGTTGGCGAATAAAAAGAGAGATGATAATGCCTCATGTCTCCAACTAAGCGAATGCGATTAACTTCAGCATGGATTTTAGGAAGTACGTTGAATGCGGCTAAAGTCCCATAGGCGAATTTACTCGGTAGTTTAAAATTTTGCTCTAATGAGCGAGCGAGTGAAAGAATACTAGTGGTTTCAGTAAATGTAGCTCCTAAAAATACATAAGCGTAAATTCGTGTAAATAAAACGCTGGCATGGTAGAGACTATGACCTGGAGTAAAGTAATAGATCGTAATAAAGACTACTAAAGCTGCAAATAATGGGATTAAAAAGAGCAAGAGTAGTTTTTTAGGGCTGAGATGCTTAAACGTGAGATAGCCAAGACTAGCTATAATAATTATTATATTTCCAACCAAATTAGGAATAAGCGATATTTCAAGTGAAATAATTAAAATCAAAAATAGTTTCAATCCGGGATTCATGTTGTTTACCTTTTTAATTAGTGTAGAAAAGTTTCTGATCTTTGATAGTTAAGTGATAGTCACAGAGATGCTGAACTTGTGCAAGTTGGTGACTAATGACAAGCAAGGTGTGGTTAGAATTAAGAAAGTACTTTTTAAGCAAATAAATGACCTCTGAGACGCTTTCTTGATCTAAACCACTAAATGGTTCATCTAGAAGTAAAACCTCGGGATAAGCCATTAACATGACAAGAATTTGCAATTTTCTTTTTTGTCCTCCAGATAGAGAATAAACAACTTGTTCGCCTAAATTTTCTAAGTTGAGTTCAGTCAGCAGGTGCTTGAGCTCAGTTTTATTCAAGGAAGGGTTTTGATTGTGTTTTAGGCTAAAGTCTAATTCTTCCTTTACTGTAACATTTAAGAATTGGTCATCTGGATTTTGAAAAAATTGTCCTACTTTTGCTAGATAGGGATGCCGGCGCCATTTCTTAATGTCTTTACTTTTAAATATTAATTGTCCTTGATACGGAATAATTTTGGTTAGAGCTTTAAATAAAGATGTCTTACCGCTTCCGTTTTCGCCAGTTAATAAAGTGGCTCTTCCGGAGTAGATTTTTAGATCAGTTGGAGAAATTAGTTTTCTTTCTGGAAAAGATAATGAAAATGATTCAAGTGAAAATACTGGATTTTGTTTTAAGTCAGGAAGAGAGAAAGTTAATGCTTGATTTTTTAGCGTGTTTTCAGGCAAAGTAATAGTTTTAATATTTTTGTCTTTGATAGCCAAGACCGTGGAAACTAGCTTTTCATAGCCAGAGAAATTATGGTCGCTAATTAAAATTGTTTTTCCTTCTTTGTGAAGTGCAGCTAAGCAAGTTAGTAGAAACTTCCGATTATGAGAGTCGCAATTAGCAAAAGGTTCATCTAATAAAAATAAGTCGCTTTTCATGGCAATCAGGATAGCTAAGGCAACGCGCTGCTTTTCACCGCCTGAAAGCTGAAGAAAAGGTTGGTCTAATAAAGATGAAATATTAGTTCTAGCACTTGCGTAATTAATACGCTTTAAAGCAGCAGTACGATCAACTAGTTCATTTTCTAAGGCAAAAATTAGTTCTTCTCGAGGAGTCGCCATCGTAAATTGTCGGTTAGGGTCTTGAAATACCATGCCCCAATTAGTGAAAGGCTGTTTTAAAGAACCAGCAGTAATTTTGCCATTGAAAGTTGGGTCAAGGCCGGAGATGAGCTTTAACAGAGTTGATTTGCCACTACCGGTTTGACCAGTCAATAGAACAAAATCACCTTGATTTATGGTTAAATTTAAATCTTTAAAAATTGGCTGATTTTGATATTGAAAAGATAGCTGATTAATTTTAATTTGTTTGGACGACATGGGCTTTTACCAAGAGGTTAATGATCAATTTAACTAAAACGCAGGTAAACAAAAGCATTGAAAGCCAACGAACTACGAAGTAGAAAATCATGTTAAAAGTTGAAAAATAGCTATAGCCATTCTTAATGAAGTCATACAGGTAGGTAACGATTGTTGTCGTTGTAGCAGATAAGAAAAGGGTGAACCAGTTGTAGCGACGGTAGCTAGTAAGAGTAAAACCTAATTCGCTACCTAAGCCTTGAACAGCTCCAGAGATCAGATTTACGGCTCCCCATTGTTCTCCAGCGATAAGTTCAACGCAAGAACCTAAAAATTCTCCTAGAAATGCAGCCCCAGGTAGTCGAACTAAGAATCCCGCTAAAGGACCTGCCATACACCAGATTCCCATCATAATATCATTGGCTAACATTCCATAACCAACCGGTGTAAGGAGCGCAGTTAAGACATTATAGAGGCCGTCACTAACTAAGTAAATAAAGCCAAAAATAATAGCAATTAAAGCAATTAGGATAATATCTCGAACATGTAATTTTTTCATTTTTTCCTCCCGAAATAAAAAAGCCACCTCAAAGAGGTGACTAAATAAAAGTCTAAAAATAAATCATTTTCCCTACGCTGATGTTAATCAAACAGGTTCAATGGGTATATTCTCAGCGATCTGGCACCCCAGTTATATTTCTAGGTTTAGCTTACGCTTAATAAGCCGAAATGACAATTAAAAATAGCAAAAAGGTTATAATTAAAATAGAGTGAAAGCAAAGGGGACCGGTTGAGATGGCAACAGCGACATTAAAAAATTATTTATCAAGTTTAATGCAGAATACGCAAGGTACTGAAATAGAGATCCGTACTGAAAATCTTCTTTTGCCATATAGTCTTTATTTAGAAACAGTGCATTATGATTTTACTGAATATCAATCTAGTACTAGTCAATTAATTTACTGCTTTGCGGGTAAGTGTGAGGTTGAAATTAATAATAAAACTTTTTATTTGACGGCAGGAAATATTTTGCTAATTGAAAAAGACACTGACTATATAATTAAAGTTAGTGATAAAAACGCAATTATTGTTAAGTTTAAGCTAAAGAGTAATTTTTCATGGCAAAAACAAGTAGAACAGTTAGATGCCAATACACCCACCGAACAAAGATTGAGCACATTATTTTTAAAAAAGTTAAATCAAGATAGTGCTTTTTTATTTACAACTACCTCTGTAACGTGGGGTAGTCAAAACTTGAAAGGTATAATTCAAGACTATCTTAATAATGTCGCTTTTAATGGAACAATTGGCTTAGAGCTACTTAAAATTATAATCTTACGCAATTTGCGCGAACAAAACTTTAAAGCAAATGAAGTAAAAGAAAGTACATTTAAAGATGAAGCGTTAGATCAATACATCGACCAACACTATAATGATATTAGTTTAGCGCAAGCTGCCAAATATTTTGGCTTTAATCGTAATTATTTTTCTACAATGGTAAAAGAAAAAACGGGAAAGAGCTTTGTTGAGCATGTCGATGAAAGAAGGATGAAAGAAGCTAGAAGGTTATTGGCCAAGCCAAATGTTTCATTAAAAGAAATAATTGAAACTATTGGATATTCAAGCAAGTCGTTTTTCTATAAGAAATTTAAGCATTATTATGGCATGACTCCAGCAGAAATGAGAAAGAGACTATTTAGAGAGGCTCATATCAATTTGAAATAATAGAGTACACAAAAAGGGATGCCTTGTGCATCCCTTTTATTACATGTTTTCCAATCTCTTAATTCTGTCTGCTGTAGGCGGATGAGTATCAAATAATGAGCTCAAGCCACGCTTATGAAACGGATTTTCGATGTATAAACCAGCGCTTGACGGATCTGGATCTTTCATTGGCTCGCTATTTGAAATCTTTTCTAAAGCTGAAATTAACCCTTGAGGGTTTCTAGTAAGCTCAACTGAACTAGCATCAGCTAAATATTCACGATTACGTGAGAGAGCCATCTGAGCTAGTGCAGCAGCAAGAGGTCCTAAAATTAATGTGAAAACAATGGCCACTATTTTAAAAATTGTTTCTAGAGAGCTAGAGTCATCGTCATCACGGTCAGAATTGCCGCCCCACCACCAAATACGGGACGCAAAACTAGAGATAAATGAAATTACAGCAGCTAAAGCTACTCCAATTGTAGATACTAAAATGTCATAATTTCGAATATGAGAAATTTCATGGCCAAGAACACCCTCTAATTCACTTCGATTAAGTCGCTTTCTTAATCCAGTAGTAACAGCTACGAAACTGTGCTTAGGATCGCGCCCAGTTGCAAAGGCATTAGGACTTTCATCGTTGATAATAAAGACTCTTGGCATTGGAACCTGTCCCGCAAGTGCCATATCTTCTACAATATGCCACAATTCTGGATCATCTTCTTCATGAATCTCTCGGCCATGATTCATGCTCATGACTAAATTTCCCGGATTTTGAAGAACAATAAAAAGATAAATTAAGCTACCGATTAGGGCAATTACAATTCCTGATAGCGGTTCACCGTTAATCAAATATCCTAACCCACCACCAACAAGAGCTAGAATAATAACGAATATAACAAGCAAAAATGCTGTTTTACGCTTATTGCGTGCTATTTGTTGATAGAGCATTGATAGACCTAGAATTTAACTTTAGGCACAGCTTTTTCTTCAGTTGGTGTTTGAAGGTAGTCCATATTCTTAAAGCCGTGAATCTTAGCGACTAAGTTAGATGGGAAAGTTAATAGTTTCTCGTTAAACATAGCAACAGTTGAATTGTATAACTGACGTGAATATGCAATCTTATTTTCAGTGTTTGTAAGTTCTTCTTGAAGTGACATGAAGTTTTGATTTGCTTTTAAGTCCGGGTAATTTTCAGCTAGAGCAAAAATACTCCTCAACGAATCAGTAATTTGGTTAGAAAGTTTAATAGCTTCTTCGTGATCGGAATTAGGAATATTTACTAATTGATTTCTTAGAGCAACTACTTTTTCTAAAGTGCCGCTTTCATGTTTGGCATAACCCTTAACTGTTTCAACTAAGTTAGGAATTAGGTCGTTACGACGTTTTAATTGGACATCAATTTGACTCCACGCCTCGTCAGCATGAACTTTAGCTTTTTGCAAGCCATTGTAGATACCAATATAAACGGCCACCAGTAAAATTAAAATGATAATAATAATCCATGTTAAAGTCATAGAAATAAATCCTTTCTATTATCATAAAAATATGGTTAGAATGTTAGGAATATTGTACCAAATAAAGAAAGCTTAGAATACCAAAAAAGCGCAAAATTGCGCTTTTTTTATGATATTTAAATAACAAAATCTAATACTATCCAACCTAGAACTGTCAAAATAATTAAACCTGCAAATTCTAGAACTGAAAATACCCAGAAAAACTTTCGTTTTGAAACAGTTCCGTTTTCAACAAAACTCTTGAAAACAAGCATATTGGCCATTGAACCAACGATTGAACCGAATCCTCCGATATTTGAGCCAAGGAATAAGGCTTCCGCAAAGTTAGTAAATTTACCAATTAAAATTGTTGAAGGAACGTTAGAAATGAATTGACTGGAAATAATAGAAGTCAAGAATACAGAATGTTCGGAGAACATTGTCTTAGAAATTAAAGTAACAATAAATGGAATTTGCTGGATATCGCTAATAAAAATGAAAAAGCATGTGAAAGTTAGAAGTAGAGCATAATCCACATGTAACATAATAGAAGGATTAATAATAAGAGCAAGGATCACTGCAACAATTGCAGGAACATATGCAGGTACAATATTGAAAACGCCAAAGAAGAAGAAAATTGAAACAGCAATCGTTAAAAGCATTGGTCGAATGCTGATTCTAATGTCTTCTAAAGGCACAGTAGGGATTGGCTTATCTTTAACAAAAAAGATAAACACTAAAACAATAATTAAACTAACTAGTAATAATGGAATTGACCAACTAAAAAACTTAATTGGTGAAACATTATAACGGTTAACAACAAAGATGTTATGAGGATTCCCCCATGGCGTAAAAGCAGCGCCAATATTTGCGCCCATCCCAATTAAGGTGACAGGCAATATCTCAGGTAAGTGATGGCGTCTAGCAATCGTTAAATATAACGGTATAAGAGTTAAAACAGTTATATCATTAGTTAAAAACATCGCAGAGATAATTGACAAAATTGTGAAGATTGCAGTTAATCTTCGAGTACTCCTAGCGCTTGCAGTTAGTTTATAGGCCAAGACATCCAAAACATGTAAGTAAGAAAAAATTTGGATGATTGTAAGCATTGCTAGAATTGAGTAAAGTGTATGGAAGTTAATATCTTCAATACGCGGTCTTGCGAAGAATAAGCTTATGATCGTTATGACAACCGTAATTTGTAAAATACGGTCTTTAGCAATATTTTTGATGACGGTCATTAAGGTCCCCTCTTAAAATTAATTCAACACTACTATTTTGAACTCTTTACGGCAAGTTCGCAACGCTTTTTTCGCATTAGTCCTTCCTATTAGTAAGATTTTGAGCATTTTATTAGGAAAAACGGTAATTAACCTGCTATATTTAAGTTAGTAAAAGAGGACGGAGGAAAATAAATATGGTTGATTCCAAGAATCTTGAATTAAAAATTAAAGATAGTGCTAAAGAAGTTTTAGAAAAGAAAATTAAGCCAGGACAAGTCGTTTTGCTGGCTTTAAATGATGGTTCAAATGGCTATTCTAAATTAGGTGGAACTTGTACAATCGGTGCTAATTTTCAACTAGTGTTGCTAGATCATAAGGATCCAGAATTTTCAATTAAGGTTAACAACAACATGGGTTTAGATATGTATACATCTGATAAAGAATTAGCCTTTTTAGACGATGGTTTAGTTCTTAATGCTCGTAATGCTACTCTATCCTTATCTTCTAATGAAGGAATCATCGATGGCGGAGTTACTATTTCTGAATTCAAAGGAGAAAAACTTTCTGCTGATGAGATGAAAAAATTAGGTGGAAAGATCTGCTAGGTATTGAAGTGACGTGCTTCTTCGTGGTATGATAATAAAAGATTTTCGAAAATTTTATTTGAGAGGAAGTATAGATCTATGCGTAAAGGTGAAAACTACAACACTGGTGTTACACCAAACTTAAGACCTAAGAACAAGAAGAACTCTAAGGCTCGTGTTAAGAGAGCTGCTGAAGTGGTTGCTTTCTTAAACAAAGCTGCTAAAGATGAAAACAAGTAATTAAATTTACTGCATAAGATAAAGAGAGACGCTGGTTAGCGTCTCTCTTTTTTTGCATGTAAAAGTTATATAAATTCTAATTTATTTAATAACATTTTGTTGTAAATGAATTTATATTATTATATAAAAAGCCTTATAAAATATGAAAAATTGAACATAGGATAGAATTTTAGATGAATAACATTTCGAGAAAAGGGCTAGAAGTAAAGGCAGTTTTTGCCCTTGTTTTACCCTCTCTTTTTTTAGGACTAGCAAGTAACTTTTCCCGCAATATTTTTTTAGGAGTTATGCTGCTCTTAATTTTGGGAGCAGTCGTCGGCTTGAGCATACCAACTATTGTTAGTACCTGGCTTATTTTGATTTTGACTGTACTAGGGATTAGCTCTCTAACTCTTGGATATGCGGCGATAGATTTTTATGGAAAGACCCTGCTGCTTATTTCTTTTCCCTTAGAAACATATTTAACTAGTCAAATTAAAGAGTGCGTTTTTAGATGGCAAATATTTAAGAAAAATCAGTCTAGTGCTTACCGTTATCTTAAGCACTACGATCAAAATGTAAAATTACAAACGACATATAATGCAGAGAAGTTATATAAAAAGATTAAGAGAATTTTAACGGAGAAAAATTATTTACCATTGTGGTGTGATTTTACGATTATTGATTGGGAACATGATCAGCAGTTTGCGCAATTTAATTTAGAAGATCATGACAAAATTTTGCAGCAAATAGCAAGAGTACTTAAAACAAGTAGATTAGTTGATGAAAATTTATATTACCTGGGAAATGGTCAGTTTCTAATTATCTCTAATACGATCGCACCAGGTACATTAATGGTTTTAAATGATGAACTAAAAGCTGAGTTAAAAAGGCTACAGTATGGGGAATATCAGCCTGCTTTTAAAATGGCAACGCAGCACATTACAGAACAAGATTTTCTTGAGTATCCTAATTTTAATGCAATTCTTAAACGTCTAAAAAGAAAGCTTGAAACGGACTTAGTTGTTGAATATTTAAAGGGAGTAGAAGCATGAGTAATTGGTTCTTTTTCTTGGTAATTTTGGTTACTTTAACATTTCTAGTGGCATTTTTTGCTATGTTTCGTAGCCTCTGGACTATTTATCATCAAACTGAGCATACAGTGCGTCATTTAGGAAGAAAGCATAATGTTAAATGATTTTTTAGCTGTTTCAACTTTAGTTTCAATTTGGTTTTCGCTTTTAGCTTCGTTAGTTACTCTTTATGGTGCAACTCGTTTTTGGCTTAAGCATAGTAAAAAAGTCATTTCAATTACGCCACTAAAGCATTACCCCGCAATTACGATTGTTGTTCCAGCACATAATGAAGAAGTGGTAATTGCAAATACCACTAAGGGAATTCTTAACTTGAATTATCCTGCATCAAAGGTCGAGCTACTCTTATATGCCGATAATTGCCAAGATAAAACTGCAGCTGAAATGCGTAAGACGGTAGATTTACCTCAATATAAATACAGAAATGTACAAATAATTGAACGGCGTGGCTCAGGCGGTAAAGCAGGTGTCTTAAACGATGCCTTAAAGATAGCGCAGGGAGAATATATTTGCGTTTATGATGCAGATGCATTGCCCGAGAAAAATGCTTTATATTTTTTAGTGAAAAAAGTTTTAGAGAATCCCCAACGATATATGGCAACTTTTGGCAGAAATAAAACACGGAATGCGAAGCAAAATTTTTTAACTAAATGCATTAACCAAGAAGTTATAGTGTCTCAAAGACTTCAACATGTAGGTGTTTGGAATTTATTTAAAATTGGGCGAATTCCAGGAACCAATTTCATCATCAATACTGAATATGTAAAAAAGATTGGTGGTTGGCAAAGTGGCGCCTTGACTGAAGATACCGAAATTTCTTTTCGCATTATGGAAGATGGCTATTTGATTGCTCTAGCGTATAATTCAGAGGCTTTTGAACAGGAACCTGAGCATTTACGTGATTATTATTATCAACGATTACGTTGGGCTAAAGGAAATTATCAAGTAGTGATGAATAACTTTAAACACTTATTTGATACTAGTAACTGGCGTGTAAAGCTAGAGACTTTTTATTTAGCATGTACTTTCTTTTGGTTTAATTTAGCTGTTGTTCTTTCAGACATTATCTTTTTTGTGGATTTGGGATGTATAATTACAAGATTTTTCAATCCAGAAATCCCAATTATCTTTGCAATGAATTCTAATATTCTCTTAATGCAGCTACTATTAATTAACTGGCTATTAATGATCTTGCTCTATGTAATTCAAATAAATCTCGCTTTAGCTACTCAATATGGTCAAGCAACTAGTGATCAAATCTGGCTAGCTTTAGTGTCATATTTTACTTATTCGCAACTCTTCATTGCTATTTCTCTGCAAGCAGTCTGCTCAGTAATTGGAGATAAGGTGTTTAAACGAGATGGTACTAAGTGGGTGAAAACCAAAAGATTCGCAGATTAGGAATAAGAGATGAAAGTAAAGAATTTAATACTGATTTTAGGAACTATCATTGCTTATTTAGGAATCATCGCCTATGTGAGGATGAGCAATGATCGAACGCTAGAAGAGCGATGTTATCATTCGTGGCGTGAAGATTATATAAAAAATAAAAATCAAAATGAGCAATATGTGAATGCAGCAGGAAGAAATAATCCTTCATTTGCCTTATCTGAAGCACAAGGTTATGGAATGTTACTGGCTGCTAAAGCGGGAGAGAAACATTTAGGAAGTCGGATTGATTTTCAAAAACTAGATAATTATTACCTGGCTCATCGCTTAACAAATTCAAATTTGATGAGCTGGAAACAGAAAGATAGAAAAAATATTTGGCGTGATAATCCTGTGAGTGCAAGTGATGGTGACATAATAATTGCGCAAGCTTTGCTGCATGCTGATAGAGTTTGGCCAGGACATGGTTATAAGTCACAAGCTGTTAACTTAATTAATGATATTAAAAGGCTTGAAATCAATCAGAAAGCTAAAATGGTAACTGTCGGAAACTGGGCTAATAAAGATTCACGCTTTTATAATGTACTGAGAACATCAGATGTAATGCCAAAAGCGTTTGAAGAATTTTATCAAGTAACTGGGGATCAAGCTTGGCTAACAATTAAAAGAAAAATGCTTAACTATTTGCAAAAGTTAAGCAAGAAGTACAATACTGGTTTAGTTCCTGATTTTGCCTGGATTTCTAATAATTATGTTAGGCCCGCACAAGCTAATGAAGTGGCGATTAATGATGATGGTCACTACAGTGCAAATGCTTGCCGAGTTCCAATGTTGTTAGCTGAAAGCAATGATAAAGAAGCAGCTCAAGTAGTAAAGAAGATGCTAAAATTTTTTAAGAAAAAAGGGACTTCAGCTGGTTTTACCTTAAAAGGTGAAAAATTACATCATTATCAATCAGCGAGCTTTAGTGCGCCAATCTTTGTAGCGGCTAGTAAGTATCGTAATCAGGGTTATGATACTTTGATTGAACAAGAAAAATATATCTTTTCAAGACCACTTCCGAAAGATAACTATTACGATGCTACTTTAACGGTTTTAGCTGCTTTAAATACAAATGAGTTGACGGGATTAGAAAAATAGAGAAAGATTAAGTTGTTGAATCTTTCTCTATTTTTGATTTGCAAGAGTAGAACGGTTTTGCTATGATAGTAGAAATTTTAGACATCTTTATATTTCTGGAAGGGGTAAGTTTTTATGGGATTAAATGCATATATTCAAGGTTTTAATAGTTTAGAGTCAATCGATCGTGCACCAGGTTATTTTAAATATCAGCATCATTCTGTCGCTGATCATAGTTTTAGAACAGCTGAACTTGCTCAAATGATGGGAGATATTGAAGAAGTTGTTGGTAAACAAAAAATAAATTGGAAAGCCCTCTATGAAAAGAGTCTTAATCATGATTATACCGAGCGTTTTATTGGTGACATTAAGACTCCAGTTAAATATGCAACTCCACAATTGCGGAAGATGATTGGAGACGTTGAAGAAACAATGACTGCCAAATTTATTAAGGACGAAATTCCAAAAGAATTTCAAAAAATTTATACTAAGCGTTTGTCTGAAGGGAAAGATGATACTTTAGAAGGTAAAATCTTATCTATTTGTGATAAGTTAGATTTACTTTATGAAGCTTATGGTGAAATTGAATTAGGAAATCCAAATCCAGTTTTCATGCAAATGTTTAAAGAAAGCCTTGAAACGATTAAAAAATTTGACGACTTAACTTGCGTTCAATACTTTATTAAGAAGATTTTGCCAGACTTATTTAAAGGTGACTTTGCTGGTAAAGATAAGATGCAAAGAATTGCTTTTAGTATTTTACTAATGGGGGAAGAATAGTTTGAAATTTCAGTGCGCATCCTGTGGGTTGCGACTTGACAGCCTTCATTTTAAGCAAGAAGGATTAATGAATCCCAAGTTAACAAGTATTTGTGATATTTGCCTAACACGCAATCTAAATGCAGAAGATTATGAAAATCCAGTAATTGAGAATATTTCCCAGGTAATGCTCTATGGCTTTGTAGGAAAGAAAAATACGGGTAAGCTTAATCTAGAGTCTTTAAATCAATATCTTGTAGGAAGCGATCATAGACGCCAATATGAATCTTTTATTCAGGATTATGATGGTAATGAAGTAGCTCTCCAGCAATTGTCACGATCTGAATTTAATCAGGCAATTATTAAGAGCGAAGATAAAGAAATAAATTATATTCCTAATAGCAATGTTGATTTTGCGGTTAATATGAAAAACATGGGAATTGAAGTTGACTTTTCTTTAAATGAAGTCGATTTTGTTGACCGTGAAAGAATTCGTCATAAATATAATTATCGCTGCCAATATTGCGGTAGACGCGGGACGAGCGTAGATCACAAAGATCCAGTTTCTTTATCGCATGATAATTCTTTTGATAATCTGATTTTGTCATGTAGCGAGTGTAATCGAATTAAATCTAATATGCCTTATAATTTGTTTACTAAGCTGAATAATCAACTTACTGTTGTAAATAGAAAATTGGTTAAGTACGAAGATACTCTTGCTAATTTAAAAGAAGAATTTCAGCAGGCAAAACGTGATTTGGCTGGACAAGTTCATTTAAAAGGGGTAGTTAATGACCCTGAATTAAATGCGATGAGAAAGCAAAATAAAAAGCTTCAGGATGCAATTGATAGTTTGCAGAGCGATTATGATGCTTTAAGGAAATTGCGTAAGACATATTTTGAAACTGGTTGGAAACTAGCACAAGAAAAAGAAAATAGTGAGATTATATAGTAAAAAAATGCATTGGACATAAAAATCCAATGCATTTTTTGCTATCTTAAAGTTCATTACTTCTAAAGTTACGTAAGAATTTCTTAGTCTTCTCTTCTTGAGGATCATTAAAGATCTCTTGTGGTGTACCTTGTTCAGTGATAACTCCATCACTCATAAAGATAACTTGATCAGAAACGTCACGAGCAAATCCCATTTCGTGAGTAACAATGACCATTGTTAAGCCAGTTTTAGCTAGTAACTGCATAGTATTAAGTACTTCACCAACCATTTCAGGATCTAGCGCACTAGTTGGTTCATCGAAAAGTAAGATTTCAGGATCCATCGAAATTGCCCGCGCAATAGCTACACGCTGCTGTTGTCCACCAGATAATTGTTGAGGCTTTGCAGTTAAGAAAGGTTCCATGCCAACTTTCTTTAAGTTCTCAATTGCAACTTTTTTGGCTTCTTCTTTAGAGCGTCCAAGAACCATTTCTTGACCAATCATACAGTTTTGAAGCACGTTTTTATTATTAAATAAATTAAATTGCTGGAACACCATACCAACCTTTGATCGGAATTTATTGCGATCAAAATGAGAATCTAAAATATTGTTACCATGGAATAAGATCTTACCATTGCTTGGTTCTTCAAGAAGGTTAATACATCTAAGCATGGTCGATTTACCACCACCAGATGGCCCAATAATGGTCATTACTTCACCTTTATTAATATCAAAAGAAATATCTTTTAATACTGTGTGGTCGCCGTATTTCTTTTGTAAATGTTGTACTTGTAAAATGTTTTCTTCGTTATTATTGTTCATGTTCAAATCCAGTCTCCTTTGGATCTTCTACTTGTAATTGATTAGCCATTAAGTTGTAGTTCTTTGGACCTTCAAGCTTCTTTTCAATGAAATTAAAGATTCTAGTAATTGAGAATGTCAAAATTAAGTAGATCATTGAAATAATGAAGTAAGTTTGGAAGAATTGGAAGGTTTGACTGGCAACAGTTGTACCAACAAAGAACAATTCTGATACAGAGATAATACTTAATACTGAAGTATCCTTAATGTTAACAATAAATTCGTTAGTAATTGATGGCAAACAGTTTCTAATTGCTTGTGGTAAAATGATATGCCACATTTGTTGTGAGTGAGTCATACCGATAGCAGAAGCTGCTTCAAATTGACCTTTAGGGGTAGCGTTAATACCACCACGAATAACCTCGGCTAAGTAAGCACCAGTATTAATTGAAACAATTACTAGAGCAGCTACTGTACGGTTTAAGTTAAGGTGCCATAATTGGGCAATTCCGTAGTAGATAACAGCTGCTTGAACCATCATAGGAGTTCCACGGAACACTTCAATATAAACTGCTAAAATCCAATCAACAATCTTTAAGCCCCACTTCTTACCAGTAGACTTAGGAGTTGGGATAGTTCTAACAATACCCACAAGTAAACCAATGAAGAAACCAACAATAGTACCAACTAAAGCTAAAAGAAGAGTCATTCCAACACCGCCAAGGATCATTGAACCATAGCGATGCATAATTGACATAAACCAGTTTTCTTTCTTGCTGCCACCTGCTTGAGGCTGTTCCTTTACAGCATCAGCCATTAATTGGTCGCGCTTTTTCTTAGAAATACCATTTAAAATGCTATTAACTTGGTTAAGTAATTCAGTGTTGCCTTTCTTAACACCAATTGATGTAATTGAATCATCGTGGTCAACTTTGAATCCTTGCATCTTGTTTAAGTTAACGGCAACGATGTTAGGGTTAACTGCCTTGTAACTTTGGTATTCAATATCTTCTGCTACATAACCATCAATAGTACCTGATTGTAAGCTTTGACGCATTGCAGAAAAGCTTCTCATTGCTGGTTCACGCTTAGCGCCATGTAATTGCTTAATTAGATCATAGTGCAATGTACCTTGTTGAGCAGTTAATTTTGCGCCTTTAAAATCATTTAAGCCTTTTGCTTGAGCAAATTTTCCAGTCTTGCTTGTAATAACTACGAAAGTACTCTTTCTGTATGGTACAGAGAAGTTGATTGCCTTTCTACGTTCAGCAGTAGGAGACATACCAGCAATAATTAAATCAATTTTGCCAGAAGTTAAAGCTGGTAATAGACCATCCCATTCGGTCTTTTCAACGACAACTTTACGATGAAGCTTTTTACCGATAATTTTTGCGATTTGTACATCATATCCATTTGCATATTGCTTAGATCCATCAATTGGAACTGCACCATTTGCATCGGTTGTTTGAGTCCAATTGTATGGTGGGTAATTAGCTTCCATACCTATTTTTAGGGGTGCTTCTTTTTTAGCCGCTTCGGTTTGACTAGAATTAGAGCTAAAACCGATAACTAAACTTAAAATTAGGGCTAATAAAGCACTAAACCATCTTATTTTTGACTTCACTTTGAAATACCTCCAAAAATTATTTCAAATAAAGCCAATACAATAAAAGCGTAAATAAAAAGCCTCGCTGTTTACCAAAAACAACGAGGTTTGAAAATCATCAGTAATTAAACCAAATCATATAGCGCTCCCTGGGGACTACCAGGACAGTATGTAAGATATGCTCTCACATCCCAACAAGCTTAATTCGCGAAAGTAAGCTTGTTTCGGCGATAATCCTAAAAACTACTGTCAATGTATTCGCGTACTCAAGTAGATTTTGTGGTTATCGCAACCTCTATTGCATTGGGGATTTATTTAACTGATGAAAAGATTAAACGATTTTTAATATTTTGTCAAATAAATCCGTGATTTTTTTTGACATCTTTTTTCTTAATATCTGAAACATAGGGATTACCAGCAACTATAAATCTTAGCTTTTTCTTGGCCCATTTAGGATCTGACTGATTGATCCCAACTCTTGGAAGAGCAGTAATTTTTTCAATTTTTCGTTTATGATTAATATCAATATCAAAAGGAGAATCTTCTAAACGAGCTAAGTCCCATTTTCTACTAGTAATTCCAAAAGCCTGCATCATCTTTCCAGGGCCATTAGTTAAAAGTGGACCAGTTTTGCCGTTGCGATTTTTAATCATGGTATCAATTCCGGTCAGTGGGTCAATTGCCCTAATTAAAACTCCTTGTGGTTCACCTTCTGCTTGGCACGCAACATCAAAGAAGAAGTATTGTCTCTGAGAATAGATATACAAACTGCCACCAGGACGATATAAGCCTTCATTTGCCTGACTGCGTCTGCCACCATAAGAATGGGCAGCCCGGTCTTTTACACCAACATAGGCTTCTGCTTCAACTATTGTGCCTGATAAAAGTTCATTTCCATTGTTGAAAGATAAAGTTCTACCCAACAGATCTTTACTAATTTCACTAGTAGACCGATTAGTAAAAAATTCTTCATAGTTCATATTACTACTTCTTTCTAAAAATGTTGTACACTCGTACTTGAAAGTAAATATAAATTGTAGGGGGAATCAAAAGATGAATGAAATAAAAGTTGTTAGAATTTATGACCATGAGCAACCCGCAGGTTATAGAATCTTAGTAGATCGCTTATGGCCTCGAGGAATGAGCAAGGTAAAAGCTCATTTAGATGAATGGGATAAGGAAATTGGGCCAACTAATGAATTAAGAAAATGGTTTAATCATGAAGATGACAAGTTTCCTGAATTCAAGACTAAGTATATAGCGCAATTGAAAGCTAATCCAGTTACAACCGAGTTTGTTAAAAATGTAAAAGAAAAGCTAGCTCAAGAAGACGTTATCTTCTTATATGGTGCTAAAAATAAAAAGCACAACCAGGCAGTTGTGCTTAAAGATTTTATTGATAGTCAATTAGGTTAAGGCATTTTTTTGCCATGCAAGTTTTGTCGAACGTAATGAAAAATAATTGTTAAAATAACTGTACCAAAAACGATGCCGGCAAAGATGGCATCGGGCAGTTTGAAGTTTAGCGGTGGCAATGAAACAAGTAGCTTAACTGCAATGATTGTGATTAAAACATAGGCCATTGTTTGAAGTTCAGGAATAATTTCCATTAATTTGATAATAACTTCAGCAACTCCTCGCATGCATAGAATACCAATCATTCCGCCAACTAAGACGACAACTGGATTATTTGACATGGCTAAGGCTGCTAAAACAGAGTCAATTGAAAAGACGATATCCATTGACTCAATTGAAATAACAGTTCTCCAAAATAATGAAAGATGGTGCTTTCTTGTCTTGGAGCTCTTTTTCTTATGGGCTTCTTTTTTTGCCGCTTCTTTCTTAGCAACTTGTGCAGGGTGGCGAAGATCATAAAAATACTTATAAACTAAGTAAAGTAAATATAAACCGCCTAACAGTTTGATTTCCCAGAAATTAATTAGGTAAGTACCAATCCCAATTACAATAAAGCGAAATAGATAAGCCCCCCAAAGTCCGTAAACTAACGATTTCCTTTGCTCATCTTTAGTTGGTAAAACTTGCGTTTGTGCGGCTAAAACCACCGCATTATCAACTGATAGCAAACACTCCATTAAAATTAGAGTCAGAATCATCATCCAATCTTGTCCGCTAGTTAGGACATGAGCCCAGTTATTAGCGTCAAAAAAGGGTTGATAAAGTTTAATCAATTGCATTCAAATAGCCTTCTTCAAGTTTTATTAAGCGTTGCTATTCTTTCTCTCCCATTCTATAACTTCCAACCTTATCTGACGCTAAAATTACGCGATGACTTGGAATAAAAATTAGGGATGGATTTAGGGCTACCGCATGTGCAACTGTTCGAACCGAAGTTGAGCCATTAATAGCAGAAGCTAAATCATTGTAAGAAATGGTTGTTCCATAAGGAATATTTTCAATCATTTTAACAACTTGATTTTGAAATGGAGTACCAAAGCTTGAGTAGTCGATAGGAACGGTAAAGGAGCGACGCGTGACTGCAAAATATTCTTTTAATTGTTGAACATAAGGAGCCAATTTTTTGGAATCTTGGACCAGAATGTGGTTAGGATAAAATCCTAAAATAGAAGATTCAATATTACTATTCTTGGAACCGACGAATGCTAATCCCAAGTTACTAATGACTAATTCATAGGTCCATGGCTTAATTTCAACAAAATCGTAATAAAAAACTTTTGCTTGGGCAAGTGGCATTTAATCCTAACCTTTCTTTTAATTAATATATTAACTCCATCTTATATTGTACAACAAAAAATAACGAAACTGTCAAATTTTTTGTGTAAATAGAT
+>5_3#NODE_14_length_39993_cov_63.1132_ID_27
+ATTTCGGTACGGCCTAAACATGGCAAAATAAGCGCATCTTTACCACACACCAAGTGGCTACGATTTAACTTGGTTGCCACATGTACGGTTAAATTACATTTTCTAAGCGCTTCTTGTGTATAAGCGGTGTCAGGTGTTGCAACGGCAAAGTTTCCGCCCAAACCAATAAAGACTTTGATATCACCTTCGGCCATGGCTTTAATGGTTTCAACTACACCATATCCATTTTTTCTTGGTGATTTAATACCGAACACACGGTCAATATTGTCGAGAAGTTTCGGGCTAGGGAGTTCATTAATGCCCATAGTGCGGTCGCCTTGCACGTTACTGTGCCCGCGAACCGGACAAAGCCCTGCACCCGGTCTACCAATTTGACCACGCGCCAACAATAAATTTGCCAGCATATGTACGTTAGCAGTTCCGTGACGATGCTGGGTAATCCCCATACCCCAACAGAAAATTGAACGCTCTGACTCTAAAAAGAGTTTAGCCAGTTTTTCTAAATGTTCAGGTGACAGACCTGAGTGCTTATAAAGATCTGCCCACTCCGTTCTTTCGACCTCAGCAATCATTTCGTCGAAACCAACGGTATTGACTGCAATAAAGTTTCGGTCAAAAACGCTTGGTTTACCTGAGGCAAGGGCCTTTTTATCCCACTCATGTAAGTGCTTTAAAATACCTAACATCAGTGCATAGTCGCCGCCAATTTTAGGCTGGAAATAATAGCGACTAATTGGCGTACTGCCATTGGTCATCATTTCAAGCGGTGCTTGCGGGTCTTGGAAACGTTCGAGACCTCGCTCTTTAATTGGGTTAATCGCAATAATGTTACCGCCGCGTTTAGACACTTCACGCAAAGTACCTAACATACGTGGATGGTTGGTGCCTGGGTTGTGCCCAAAACTAAAAATGGCGTCGGCTAAATCAAAATCTTCTAGGGTGACTGTACCCTTTCCTAAACCAATCGAGTCGAGCAAACCAACACTTGTGGTTTCATGGCACATGTTTGAGCAGTCGGGAAAGTTATTTGTACCAAAGCTTCGCACAAACAATTGATATAAAAATGCTGCTTCGTTACTGGCACGGCCCGAGGTATAAAATGCAGCTTGGTCTGGATGATCTAGCGCATGTAAATGTTGAGCGATGAGTTTAAAGGCATCGTCCCATGAAATAGGCACATATTTATCGGTTGTAGCATCATAACGAACTGGGTCGGTTAAGCGGCCTAGGTCTTCTAGGAAAAAGTCACTTTGTTCTGATAACCAACTGACGGTATGCCCTGCAAAATATTCGGGAGTGACGGTTTTACTGGTTGCTTCAAAAGCAACCGCCTTTGCACCATTTTCACAAAAGTTAAATGCGTGAGCGTCTTTCTTTTCTGGCCATGCACAGCCGGGACAGTCAAAACCTGTAGGCTGGTTAATGTTGAGTAAGGTAATTGAACCTTTACCTAAAATATCTTGTCGCTTTAAGTTACGAGCAACACTTAGCAGTGCACCCCACCCGCCAGCAGGATGAGTATATGGCTCAATTCGCGCAAAACCGTTATTTTCCTGTATGTGCTTTTGTTCTTCTGAATTATCCACTTTTTCATCCTCTTATCTTTTTTACACTCAACAGGCTCAGTGAAATCACAATTTAATTATGGTTTTATCAAAGCTACCCGCTGTTTACCGATGAGTAGAGTCCACTTTTTATATTATTGCCACTATGCTAAAAGCCGGCTCAACCGTTCTTATAATATGTGCCATATTCTTTACAATTACAATAATTCAAGCCAACCACGTTATTTATATAAAAACATATAAATCAAATAGTTAAATAGATATTAATTCTATCTTTTACAGATAAAAACATTATTGGGTTTCATTTTTAACCGACTGAAAGCTTTTTAAAATTGACACTTACACGACTTTATCTATGTTTTTTTCGCATTAAGCAGTATAAAACAATTAAAAATTTATCTGCATTAGAGCATTTATGAAGGTTGTGATCGCCCCTGATTCATTTAAAGATAGCTTATCTGCTTTAAAGGTAGCTCAAGCCATTGCCAAAGGATGGCAAGCGGTTTTTCCCGATGCAGAAACGATTTTGTGCCCCATGGCAGATGGCGGTGAAGGAACCATTGAAGCAGTTTTAGAAGTCTGCGATGGACAATGGCGTGTAAAAACAGTGGTTGGACCATTAGGTCAGCCTGTTCAGGCCAAATGGGGTTGGTTAGAAACACAAAAAATTGCCATGATTGAAATGGCTCAAGCGAGCGGCATACAGTTAGTTCCACCGTCTGAGCGTGATGCCTGCCACAGCACAACGTTTGGCACAGGTCAGCTCATTTTGGAGGCTTTAGACGCAGGCGCAAAAGACATTATTTTAACTGTGGGCGGTAGTGCGACCAATGATGGCGGCACAGGCTTACTTAGTGCTTTAGGTGCAGTTTTACTCGATGCTAACCAAAAGGTTTTACCCGCTGGCGGCCTTGCCCTTAGCCACCTATCCAAAATTGATTTAACACATTTCGACTCACGTATTCAGCACACACGGTTTTTACTAGCTGCCGATGTGACCAATCCACTTTGTGGCCCAAACGGCGCATCACATATTTTTGGCCCACAAAAAGGGGCCTCTCCTGCTCAAGTCCAGTTACTCGATGCAGCCCTTGCCCATTTTGCTGATGTCACGGCACAATTTTTAGGTTTCGACAAACGAGATGAAGCGGGTTCTGGGGCTGCTGGTGGTTTGGGCTTTGCCGCCAAAAGTTATTTAAATGCAGACTTTAAAGCTGGAGTTAAAGTTGTGGCTGAACTGAATCAGCTTGAGCATAAAATTTCTAACGCAGATTGGGTAATTACGGGTGAAGGTAAATTTGACCAACAAACCTTAAGCGGTAAAACCGTTTTTGGGGTAAGCCAAATTGCCAAAGCCCACAATGTTCCGGTCATTGTGATTGCAGGGACTTTAGGTGAAGACTACCAAGCACTTTATGAGCACGGCGTAAGCGCTGCTTTCTCACTAGCCAATGGCCCCATTACCCTAGAACACGCCTGCGAACATGCAGCAGAACTCATTTATGAGCGAACAGTCGATATAGCGAGATTAATTCAGTTTAGCCAAACCAGCTTAAATGCTAAAAAAGTCTAATCGGCTAATTTTAAAAGACTCTCTCTACAACTTTCCAGGATTTCATCGCTAAGGTTTGATTGGTCTGGGCATGCACGAGACAATGCAATTGCCCCTACTGACTGAGCAAGAATATTAATAGCTTGCTTTCTCAGCTCTTCTGTTTCTAAAGAAACTTGTTTTGCGCGTTCATTCATAATGAACTCAATAAGCTGCTCAATACCCTCTTCAAACTTGACTTTTACTTCGTCGGGCTGTCTAGCGGCATCACAAGATAGCGCTGTTAAGGTACAACCCTGATCTCGGTTGTCTCGATGTGTACGAGACACATACATATGAATAAATTGGGTTAAGTTTAAACCTTCTATTCTTTTTAAAACCTGCTCAAGACCATGTTTGGCAGTAATAGTAACAAGGTCTGTTTTCGAGCTGAAATGTTTATAAAACCCACCATGAGTAAAGCCTGCGCTAGACATTAATTCGGCAATGCCCACCCCGTCGTAGCCTTTACTACGAAACAGTTGAGTCGCCTTTTCAACAATTTTATCTCGGTTTTCTTTTACCTGAGTTTTACTGACTTTCATGTTGGTGCGCTCACTTTTCTTCGCCCTGCTCGTCATTATTATACATTGATTATGATTGACATCAAAACCTGTATATTTTAGATTATAATCATCATCTAAAAAATTAAAGCGTGGAGACATCACATGTCATCTCAATCAAAAGTACTTATTACAGGGGCTTCGTCAGGAATTGGTTCTGTTTATGCAGATCGATTTGCTCAACGTGGCTATCACTTAATCTTGGTGGCACGAGACACCCACCGTTTAGATAAAATTTCAAAAGATCTTCAAGAAAAATACGGTGTACAGGTCGAGTTCATTCAAGCCGATTTATCAAATGATCAAAACATTTGCAAAATTGAAAATGTACTCAAAAACGATGCTGATATTGAAATTTTGGTAAATAACGCTGGGATTGCCCTGAACGGAAACTTTTTAACTCAAGATCGTAATGAGATTGAACAACTTCTAACTTTAAATATGACTGCGGTAGTGCGGTTGTCTCATGCAATGTCGCAATCCCTTATACGCAAAGGTAAAGGCGCCATTATTAATTTAGGCTCTGTACTTGGCTTAGCGCCTGAATTTGGTTCTACCATTTATGGCGCAAGTAAATCTTTCATCCAATTTTTTAGCCAAGGCTTACATTTAGAGCTAAAAGATCATGGGGTACACGTTCAAGCTGTATTACCTTCTGCCACTAAAACCGAAATTTGGGAACGTTCAGGTATAGATTTAAGCCAAGTTCCGCCATTAATGGATGTCAATGATTTGGTCGATGCAGCCCTGATTGGTTTTGATCGTAAAGAAACAATTACAATTCCTGTGCTGAAAGATGAAAATCAATGGAATAATTTTGAAAAATCGCGTATGACATTATTACCAAACTTCTCTTCGGCTGAAGTAGCCCAACGTTATAAAAACTAACGACTAGGGCTACCCAACTCTCAAGTAGGAAAATCTTATGAATGTTATTGATGCTCTCCGCAAACGCCGTGCAGTTAAACGCTTCGACCCTGCTTTTCAACTCTCTGAAGATGACAAGAAGCAGTTATTACAAGAAGTTTTAGCAAATGCACCAAGCGCTTTTAACTTGCAGCATTGGCGTCCAGTCATTGTTGAAGATGCAGAGTTAAGACAAAAAATTCGCGCGATTGCTTGGGACCAACCACAAGTAACAGAGTCATCATTACTGATTGTGTTATGTGCCAAAGTAAATACATGGGAAGTTGACGCTAAACGTGTATGGGATGGAGCTTCTCCAGAAGTTCAAGATATTATGGTTGGTGCAATCGACCAGTATTACCGTGACCGCCCACAAACCCAACGTGACGAAGTGATGCGTAGTGCGGGTATCTTTGCTCAAACCCTTATGTTACTTGCTCAAGAGCATGGTTTAGATAGCTGTCCAATGGACGGTTTTGACTTTGATGCAATGGCAAAGCTCATTAACTTACCTGAAGATCACGTGGTGTGTTTAATGATTGCGGTTGGTAAATCAGCTTCTGAACCTTACCCGCGCGTAGGCAAACTCCCTTACGATGATGTCATTATTAAAAATACATTCTAAGTTGTAATTCAAATTTTAGGCTTTCATTCTATTTTTGTTTTTATACTAAATAGATGGAAGCCTTTAATTTTGCATTAATTATAAAGCTGACTTTGACTCGGCTATAAACTGTCTCAAAAAGCAATTTAATAATCTCTCCCTTTCATCCGCGTACTCTGCACTCAAAAGCTGAATGATTGTGCCTTCCACCATATATAAAAATAGTTTGGCATCGGTAAAAGAGACATCGGGTTTAAGCAATCTAAGCTGGCTATAAATCTCATTTTTTAGCCATGTTCTATAGCGCACTGCGGTTTGATAAGCGTTGGGATAGCTATTTTTAATTTCAAAAACGGCTTTAAATAATAAGTAATACGGCCCTTCTACATCGGTATGTAAGTCATAAAGCTTTTTGAGTTTATCGATGGCAGGAGTGCTTAAGTCATATTCGACCATTGCGACTACTTGTTCTTGGAGCTTTTCTTTTTGCACCATCAGGCAGATTTCAATAAGCCTTTCTTTAGAGTGAAAGTAATTATAAAAAGTCGCTTTTGTAATCTCTGATTCTTTCACTATTCTGTCGACCCCAATAAGGTGAAACCCACGGTGGTGAAACAGATCAATTGCTTTATTTACAACGTATAAGGCACGTGTTGGGAGAACTAAATTTGGCATAGTTTTACCGTTATAAATTCTTGTTGTTTGTAAATGAGATACTTTTTTGGGAGAAAAAAAGGCACAGCAAAGCCTATAAAGACTGTGCTTGGCACATCTCAAGTTTTATTGTTGCTAAGTTTTTGGTTGTGACGATTTAAAGCCTGAAAGCGCTAATGGCCCTCAAACTGCTTTAAAGCTTATGTGGTGTCGTTATAGCTTTTGGCATTGAGAGCCAAGAAATAATGTATGTGCAAAGCCAACTCCTTTTTATTGGGAGTTCTGCCAGACATGAATAGGAATTATGGTGGCAGAACGGAAGAAGGTTGACAGACTAGTATTATCTCAAACTAGCACACCCGTAGGTGTCCCTCTCCCGTCCTACCGCTACGGGAAAGGGACGAGTAGTACACCACACAAGACTGTTCCTCAGAAGGAAAAGCTCTGATGCGGGAGATAATATTCAGCCTGTCAAAGCCGGCTGGCAATGTGGCCAGCAGGCAAAGAATAGTGCTCTGCTCTTTAGCAGTCAAGCACACAAAATGACATTTGTTTTAAATTAGATCATTAAAAAGTAAGGATAAATAATGAGATAGTTATTGTTAAATGGGGGTTTATAAAGGGGAAATAAAAACAGCCTAGAAGACAACGATCAAAAAAATGAGGCTTATTATAAGCCCCGTTCCGTTAATTATCTTGTATCTTCACTAGGGTTCGATGTTGATGAAGTACTATTCTTTGATTCTATTTCAGTTGCTTTTGGAGTGATTGCTATTACAGCTTTACTAGCAGCATCTTTAATTTGTTCGGCCACTTGACCCGCAAAACCTGGTACTGTTTGGGTCGCCTGTTTTACTATATCTGATGAAAACAATTCATGCCACGGACTTCCATGATTTTCATTCTCTACAAATCTCAGTGGCTGCTCATCTAGGCGTGATAAAGCCGATGCCAAAAGTCTTGTTTCCATATTCTTATCAACTCTAGCAGCCTCTCTACTATAGCCTTCATATGCACGAGATACAGAAGCTTTAAATGCATAATCTTCAGATAATCTAAAACGCTGGCCTATTTGTTTTGTTGCTAACCAAGAAAACCAAATTGGAGCGCCTAAAGATAAAAGAGAAAGAAGTAAATTAATAAAAATAATGATCGTTGAGCTATGAGTATCTTTTAAAAGCTCAGATAGGCTTGATAAACGTTGAGAACCAAAATAACCTCCAACTCCTAAAGCAAAAATTAGGCCTGCAACCCACCATTTTATAGACCTAGACAAGATATTCGAACGTTCAGTAAATGCCGCTGCCAATCCAACACTTGTTGCTGCTGAATATGCAGTTTCACAGCGTTCTAACACATTTTTAGCATTCAAAGCATAATTATTAATTTCTTCATCAAGTAATTTCGAATTTTGTTTTAATAGCTCAATTTCTTTATTTTCTTTCATTGAATCTGAAAACAAATTATTAATTTGTTGTCTCGCTTCCTTTAAAGAGGCTAAATCAGTCGGTAATTGTTCAGCTGCCTCCGATGCTTGTTCAATTCGTTCAACCATTGAAGTCAAAGAGTCTGTGCGAGGTTCTACTTCATGTATTTTTGCTTCAATAGAGCGAATACGAGCATTTAATTTTTTTAATTTTGTTAAAGCTTCAACTTGGTCAGCAGCAAGTTTATTTGCATATGGAACTAAAATAGACTCAAGTAAATTTTTAAGGCTATCAATAGTGAATAAATATGCTGGAATTGCTAAATTGACGTTAGATGACCACATTTGGGGAATGGTATGACTAACAAGATATTCTAAGCGTTTAATATAATTAGATATAAGAGCATCTTGATTCTGATCCAGTTCATCAGTTTCATAATTTTTAATAAAATCAATAATATGTTTTGATTTAGAAATGAGTTCTGTTTTGTTTAAGTTAGGACTACCCCAACTATTATGTGTTTGTGCTAAAGGCTCATTATTTTGAATAACGTTATTAAGTTGATTATTAACTGCTTCTAATTGCTGTAATATGTTTTCTAATGTAGCGTGCATGACTAACCCTTTCATTGGCTTTAAATTATTTTATTTAAACAATTATAATACATATGTAGGCTAGAAAGTGAACAAAAGAAAATAATGTGACATGTCATTCAATAGTTTCTATCAAATATAATAGACAATATAGATAAAACGGGATTTTCATATTAAGGTCAAATAACCTTTTAGTGTTGTCTTTAACTTTATATTTATTAGACAGCAAAATTTATTTTTTATACAGCAACAAACTCATTTTTTTAGTACTTATGTGATTTATATATTTTTATAGACAACACTAATATTTAGTACATTCTTTATTAATGTCCAAAATTAACTATAGCTTAGCTACAAAAAAGCCCCTGTTCTACAGAGGCTTTTTTCAATTCAACAACGTATTATTTATGAACCCAAGGCACAGCCGGTGAACCAATCCACGCAGATTTAGCCGGAATATTTTCACCTTTCATGACCAGTGTTAATGGCCCTAACACGGCATGATTGCTCACGTTTGCGTTATACAAAATAATACTGCGCGCATTGACCACTACATCATGCCCCACGTTCACTTGCCCGATTTTCATAATACGGTCTTCAAACAAGTGAGTTTGTGGGCCTGAAAAACTATTAAACTCGGCACGGTCACCAATGCTGACACAGTCAAACTCGGTAATATCAGCCGTATCCATATAAACGTCTTTACCAATACGAACCCCTAAAATACGCAAGAAGAATGGCAACATTGGCGTTCCTCTTAAGTAGTTTAAGAAGTTAGGAATCGCAACTGATTCATATAGGCTGGTAATCCCTTCACTTAACCATACGAACATGGTCCACATAGGTGCCGAACACGGTTGATAGCGACCAATCAAAATCCATTTTAATAGCGCAACAATAAGGAAACAGCCAACACCATAAAGCAGCCCTGCGAGCGTTAATGCAACCAGTCCTGTCTCAATATTGTAGTTATTAATCACATCAATAACGTCTAGCACGATCATATAACCCACCCCAATCGCAAGTGCGGCCGGCAATACAATACGAAGCCCTTCAATAAAACCGCGCATTAAACGGCGCTTAATACTTGGTTTAAAGGTTAAATGGTCAGGATATTTTTCAGCAGCTTCACGTGCAGGTAACAGCAACGCCGGAGAACCAAACCAAGTTTGTCCATCATACATTTCACGGTTATCTGGTGTTTTTGATTGCACGCCAATTAAAACATTGTCTGGTAACACTGCCCCATCAGCAATATAAGCACTATTTCCCACAAAACTACGGTTACCGATTTTGGTTGCTTTTAAAGACATCCAACCGCCTTTAATCTCTTCATCACCCAGCATTACCGCATCGGCAATAAAGCTTTCTTCACCCAAAGTCAGCATTTCTGGAATGACACCAGTTGCGGTAGAAATTTCGGTATTTTTACCTACTTTTGCTCCCAGCATACGAAACCATGTAGGCGCATAAATAGTGGCAAACAAGCCATGTAAGGTTTGTAAACTCGTCTCTAAAATTTGGGCCGCAAACCATTTACGATAATACGTGCTGCCATGAACTGCATAGGTTCCGGTTTCAAGACGCGGCAATGCAATTTTACGCAGACCTGAAGAAATCACCGCAGTAATCATCATCATCATTGCACTAGCCGGAATCGCTAAAATGAAATAGTAAAGCGCGATTTGCAAATGGTTGTTCGGGTTAATATTAAATACATTTACATCTAACCAGTCGACCAAAAGGAAGCTTGGAAAAATTGGAATAAAGAAAAGACAGGCAATAATTAATGCGCTAACGCCATAGTATCCATATTCAGCAATTTTACGTATAAACGATAGTTTAGGACGCTCTGGCAATTTAGCTTGCTCATCTATATGCCCTATTTTCTGAGCAGGTGTTCCATCCCAAATTTCGCCCTCAGGTACAACCGTGTCATATTCAATTGAAGTTAAGGCATTTACATGAGCTTGTTTTTCTAACACTGTATTTTCTTCTAATACAGCATACGAACCTACATAACTGTCTTGTTTAAGGTGAATTGAACCTAATACCAAGTGACCATGTTCAACTTTGGCATTTTCTAAATTCACCTGAGAACCGATACTCACGCCATCTTCAATAGTCAGTAAAGATGGCATACGAATATGTACAGAACTAATGGTAACGTCGTGACCGATTTTTGCACCAAGTGCTTTCAAATATAAGTTAAGTAAAGTCGAACCCGACAAGAGATAGACAGGTGAAATATTACTAATACGGTCCGCTAGCCACCAACGGAAATAGGTTAATCCCCATAATGGATAACGCCCTGCGCCAATTCCTAACATTAATAGTCGTTTTACCGTAATCGACAGTACAAAACTGCTCATAATGACACTGACATACACCAATAAAGACAACGCAATCGCATACGGAATACTGTCGCGAGTTCCACCGGTAAAGTAGTGATAGGTAAAGAATGGCGCTAACCACTGCAAAATATTAATCGAGATTAAAACCGGAATAGTTACAAGCTGTGCAATACCACATAACCATTTATAGGTCTGATTACAAGGGTTATCTTGTCCAATTTGGCTATCAAATAAAGTAGGTTCAGGCTGCTCTAACATGAGTGCAGCAATCGCGCCTACTCTTCTCGCTTGATATAAGTTTTGAATGGTCAGATGGCTATATTCCGCATGCTCACGCAGATTTGAAATTAAAACAGCGGCAAGTAGTGAATGCCCGCCTAAATCATCAAAGAAATCAGAATCGAGTTTAATCGGCATGTTTGGGAACAAACGATTCAAAATTTCAAATAGGATTTCTTCGGCTGGGTTCTGTGGCTGATCAGATTCACTGCGATCTACCACACTTGTGAGCGGTCTTGCTTTTAAAGCTTTACGGTCAATTTTCCCAGATAATAGACGTGGAACTTCTTCAATAATCTCAAAACGATTTGGCACCATATAAGGCGGTAATCGCTGACTCAAGTTATGGCGTAGTTCTTTAATTTCTATAGCTTGCTTTGCATCAATTTCTGGTGCAATAAACGCAATAAGCTGATCAATGCCGTCTTCAGGACGAAGAATAACGGCTGCCGTACCAATTCCGTCAATATCGCAAAGCGCAGCTTCGATCTCGCCAAGCTCTACACGGAAACCACGGATTTTAACTTGGTCATCGGCACGACCTAAACAGTGTACTTGACCAAACTCATCAATTTTAGCCAAATCCCCAGTACGGTAGAGTAATTCTTCCTCTATACTCATTGCCCAAGGGTTCTCAATAAACTTATCTGCGGTTAAATCAGGTCGTCCTAAATAGCCTTGTGCCACACTTGGACCAAAAATACATAACTCCCCTGTTTCACCTTGCTCGAGCAACTCTCTTTCAGAGTTAATGACCAACATACCGTAGTTTGGTAAGGGCTTGCCAATGGTGACAGGTTTGCCGCGTTCCAATAACTCAAGACTTGCAGAAACCGTGGTTTCGGTTGGTCCATAGGTGTTAAACATTTGATGATGAGGTAATGCCCAGCGGTCAACCAGTGAGTCCGGACACATTTCCCCACCTAAATTAATAATTCTTAAATTAGGTACGTCTTCAGGAAATAAGGCAAGTAACGTTGGAACAGCATGCAGTACTGTAATTTGTTCCTGCTTTAAGGTTTGGCATAACCGCTCAGGGTCACTGACAAGTGACTTCGGTGCAATCCACAACGTTGCACCTACCAAATAAGAAAGCCAAATCTCTTCAAACGACATATCAAAAGCGACTGAAAAGCCTTGATAGACCTTGTCTTGCTCTTGAATACCCAAGATACTATTTTCACTACGTAAAAAGTGACAAATATTTTTTTGAGTAATCACAATTCCTTTGGGTTTACCTGTCGAACCCGAGGTATAAATAATATAGGCAGGTTGATCTGGAGTGGTTTTCGCTAAACTTACACTTTCGCTTAATGGTTTTTGCAGCTCGGTGTTGGTCCATTTTGTTTGCGGCACTTCAGCTAAATGTTCATACCATTCATCTGTAGTAATCATTCCCACCGCTTCGGCATCTTCAAGACATACCGCAATACGGTCCGCGGGCGTATCCATATCAAAAGGAAGCCAAGCTGCACCGCTTAAACAAATGGCTAGTTGAGCTTTTAAAAGCTCAATACCACGCGGCAGCCATAGCCCTACAATATGACCTGGCTTTACCCCTTTTAAAGCCAGATGTTGAGCCATAATTAAGGCTTGCTGATACAGCTCACCATAACTCAGCGTTTTATCTGCTTCAATTAAAGCCGTTTTATCAGGAAGAGTTTGTGCAGTATGAGCAAAAATATCGGCTAAGACTTCATTCTGCAAAAATTCCGGATGATACTTTCCACGAATTACATTTTTCGTGTTCGTTACAAACTGGTTCATTTTTATACTCTCTTAATTTTCTGATTTGGCTTAAATGAAGTCATAATTTATTTTTCTGACCCATTAACGAAATCTAGATAGGCCATAAATTAATTAAGAGAACTTAAAGCAAGATTAAATTTTTTAGTTTTGATGTTTATTCAACAGAGTAAGAACCTTAGCCTCTAATTTTAAATTATAAATAAAAATCAAATATTTAATATTATTATTCAAATTTTATGATTATCTTTAAGATAAAAACGTACAAAACTAATGAAGTAAAAAGCTAGAATTCACAAGATTTATATAGTTCTTGTTTTAATTAAACTAATAAAAGCCATCCTGTATACAAATTCTCCATATTTTAAACTTAATTGTTTAGTTCTGAATTATTAAAAGAGTTCTTAAAAATAAAAGAGTTCATTTAAATTTATGCATGATGTTTGATTATTAATATTATATTAAAATTGTATGCATCAATTCTTTTTAACTTATATCTTTATCTGGATTTTATAAAAAGTTAACTCCATTAAGCGGATTGAGCGAGCAGTTATTTACACGTTCTACTCATAACTCAACCTACCCTATTTGGAGTGGTGAGTTGTGTGGGTTAAAACGAAGATACTCTTGAAAGGCGAGCTAAGATCACCTGTTTCATTTAAGCATGACGAAGTATCTTTATTTATAATATTTGAAAATGGACTTAAAAAATTAAACAGTGGTGCTGGTATGAGTCAACACATAATAACCCCAAAAGAAATACCTTTAGCATTTCAAACCGCTTGGAATAAGCATGATATGCAGGCCTTTGCTGCTCTTTTTGATAAAGATGCGACTTTCGTTAACCGTTTCGGTCACTACGTTAAAGGAGTTGATGAAATTATTGCAATGCATCAACCTATTCATGGAACCATTTATCGTGATTCAACACTAGAGAATGAGCTGATAGACCTCATACCTATGAGTGAGGATATATGTATTTCACATTTTTGGAGCCGCCTCACTGCAGGCGTAGCTCATCCTCAAGGGCCTCATCAGATTGATACTCTCATTCTTACTGTGCTCACCAAGAAGAATCATTCTTGGTACATTCAGGCGCTAGAAAATGTCACTTTGACGAACCCTCGTACGGGAGAGACCATACTTAGAAATATATAGAAAGGAGCACGATCATTTTTTTAGTAATTTATATGCATAAAAAAAAAGCCCTCGTCATTAACAAGGGCTTTTTAAGAATTTTGGCGGAAGCGGTGAGATTCGAACTCACGGAGGACTCACACCCTCGTCGGTTTTCAAGACCGGTGCATTAAACCGCTCTGCCACGCTTCCAACGAGCGCTATAATATAAACAAAAATGCAAGTTGGCAAATCTTTTATTTAATTTTTAATTCAAACGCTCAAAATAAAAACAAATCTATCTAAATTTCATCATTTTTAGGTTTTTCATAGCGAATTGCATTGATATACCACAGCTTTTTACCCAAAGGCGTGTGTACTTCTACTTCATCATCGACTTCTTTACTCAAGAGTGCACGTGCCATAGGTGACTCAATTGAAATATGCTGAGGATGGTGATCATAAATTTCATCTACCCCGACAATTCGTAAAGTTTTTTGCTCCCCTTCTTCATTTTCAATGTCGACCCAAGCACCAAAGTAAACTTTGCCTTCTTGCTCAGGTGAGTAATCAACAATTTTTAACTCTTCTAAACGCTTTCCTAAATAGCGTACTCGTCGATCAATTTTTCTAAGGAGCTGCTTGTTATATTGATAATCTGCATTCTCACTACGGTCACCGAGGCTTGCAGCCCAATTTACTTTTTTCGTAATTTCTGGTCTTTCTTCATGCCAAAGTTGTTTTAATTCAGCAACTAATTTGTCATGGCCTGACCGAGTGATTAAGTTAGATTTCATGATTAAAAACCACTGATTAACAACATAAGGGTTACAAGATGTAGCATTTTATACCCTATTTTCTCACATCAGAAGTGTATAAATTTTCTTCCTTAATAAATTCATGTTGTTATGATGATATATCGGATATTTAATTGTACAAAATTTGACAATACTTTTTCTCAATATTATGATGCGCGCATCTTAAATGTTGAGTATTTTTTAACCCACTCAAAATCTATGTAGATTTTCTACACAGTTTGCTTTTTTCATTTCATGTCATTTTGAATGACGTCATGACTGCCCACCCCTTATTGAATTTATCAACTTTTAGAAGTTATGGCAGCTTTTTGTCTGACTTTTAGGGCATAAATTACCTGTAGCGGAGACAACATGCACAGTAATTCAAGTTCTGGGTCGAGGCTTGGCCTTAGCTCTTTATTTTCTTCTCTCCCATTGAAAGTTCTTGCGCTCAGCACTATGTTTTTTCCCTTTCATAGTATCAATGCAGGAAAAACCCTACAGTACAATACTGTAGTTAACACAAACACATTAACAGTAGTTGCCGTAGAAAGCCCAACGACTGTTTTTAAAGAAGACCAGTTTTTACACGGCTTCGGTTATGACTTAGCGCGTAACTATGCACAAAGCTTAAATGTAAAGTTGGACTTCAAAATCGTGACAGACAATGCCACGGCACTTAAGTGGGTTCAGCAAGGTAAAGCAAATCTTGCCATGACAACCGCAAGCTTAAGTTCAATCGAGAACAAAGGTTTAATGTCTTTTTCTGCAAGTTGTGGTGATATCGTAAATTTGCAAAAAAATGGATTAAATCCGAATCTAAGCTGGGTGTTTAAACAAGCAGATGACCCGCTTACACAAACAGCAAGCGGTTTTGTTTGTCAAAGCAAACAAAATGGTCTAACTCAGCAACTTGCTTCTTTTTATAACCGTAATGTTGTAAAACCAGAAGCTTGGTCTACGATTCAACGTGACTTAAGTGCACGTATACCGATTTACAAAGCAAGCTTTAAACAAAGTGCTGCTCAGTACGATTTAGACTGGCATTTGCTTGCAGCGATTGGTTATCAAGAATCGTACCTAAAGCCAGAGTCTGTTTCACCAACAGGTGTACGTGGGTTAATGATGTTAACCAATAGTACAGCTCGGGCAATGGGTGTGAGTAACCGTAATGATCCAGCACAGAGTATTCAGGGCGGTGCGAAATATTATGATCTCATGTTAAGTGAGTATGATGATATTCCTTTCCCAGATCGCAACTGGTATGCGCTTGTGGCTTACAATATGGGTCCAGGTGCAGTGAACCAGATTCAAAAGCGCTTGCAAGCCCAAGGGAAAGACCCGAACCAATGGGTTAATCTCTATAATTATTTGCAGAGTAACAAAACTCGCAATGGTCGATACAAACAAGCAGTTCAGTATGTGACTCGTATACGTGCTTATCTTGAGCACATTAAAACGGCACAAACGCGAATTAATATCTAGTTTTTATCATCTAAAAGTTGATAAATTCATTGTTTGTATAAATAAAAAGCTTACCTCTCGGGTAAGCTTTTTATATGAATTCTTTTTCAGTTTAAGCGGTTTGCTCTAATACTTTTTTGAACAAATCTTTTTGTTCTTGGCTTGGTTTAGCTGTTTGTAAAGCCATTAACTGAGACATATCGCCTTGAACTTTTATTTTACCAGTCATGAATGCCTGCATAGCAGCTGCCATATCAAACTCTAGGAATACTTTACGTAAAGTTTCAGCATCCATGTTTAATGTAGTTTTAGCATTTGAAGACAAACCTTTTTGGATTTTACCCCCATCTAACGCTAATTCGGTATTTCCAGAAGCATCTGTAACTACTAAATTAATTGCCAAATTCGCAAGAGCTGGTGGCAAATTAAGATCACCTGCTTCAGCAGTTAATTTTTCGACAGTCGCAAACCAATCATCAGTTAAAAATGCAGGCATGATTCTTCCTCAAATTTATTTGTTCAATTTCTCTAGTGTTGCCTATCCAGACAACATCGTGTGAAGCACTTCTGCTTGAGCGTTGTTATAGCATGTAATTTTAAGGTTGAGCTATGACTTTTTGTACGGAACATTCATTTTTTAGTATTTTGATACATTAAAGGCACTTGTTTATAAAGTGCCTTCAATTGACTTATTAATTCGTTTTATTCAGCAGCAAAGCTTAAGTTCACTACATCTAAACGTTTTTTCAGTTCTTCCGGATCTTTAAAGTCTAATTCGCGCTGCGAGTCAAGAACTTCGAAATCGAACAAATCACGGTCAGCAAGTTGTGAAGGTGAAACGTTCTGTAACGCACCAAAAATGCTGTGTAAACGTTTTGGATACTGTTTGTCCCATTCACGAAGCATTTCATTGATCATGGCACGTTGCAAGTTCTCTTGTGAACCACAAAGGTTACACGGAATAATCGGGAACTTACGTAACTCTGCATATTTGATAATGTCCTTTTCTTCAACATAAGCCAAAGGACGAATCAAAATATTTTTCTTATCTGACGATAAAAGCTTAGGTGGCATTGCCTTTAAGCTACCGCCATGGAATAAGTTCAAGAAGAAAGTAGCAATGATGTCATCACGGTGATGCCCTAGCGCAACTTTGGTTGCACCAATTTCTTGAGCAAAGCCATAAAGCGAACCACGGCGTAAACGTGAACACACAGCGCAGTACGTTTTACCTTCAGGAGTTAAACGTTTGGTAATGCTGTAAGTGTCTTTTTCTAAAATGTAATACGGAATGTTATTCTCTTCCATATAACGTGGTAAGACATCTTCAGGGAAACCAGGCTGCTTTTGGTCAAGGTTAACCGCAACAATATCAAAATTGATCGGTGCAATACGTTTGAACTGCAACAAAATGTCGAGCAAGGTATAACTGTCTTTACCACCAGACACGCACACCATGACCTTATCACCATCTTCAATCATATTGAAGTCACGGATGGCATGTCCAACTTGACGGCGAAGCTTCTTAAGCAAACGATAATAGGCCGAGCTTGTTGGAAGTTCAGGCTTAAAATTAAATCCTTCGTTGGACTCAACTGGCGCGTACATAGACGAGATATACCCATAAATAAAAATACCGCGCAATTTTATATGATTCGGATGAGAATCGCATCAAAAGAATAGTTTCAATTCTTGAAGTCGTCATAATGCTCAGGCATGATGCAAAAGCAGTGCGCTATTTTGACCGATGAGTTCATTTTTTGCGCAAAATGCTTACTTTTTGGACTTTTCCACAGTTTTCCACAAAACCTGTGGATAAAATTGTGGATTTCTTAATACTTGACAAACTGTTTTGACCTTCTGTTAAGGGTTTTATTTAAATTGATCATTTTTTAACCAATGATTTTTACCCTTATTTTTCAAATAGTTATTCAAGTCAATAGAATCATTTTAAAAATTTTTTTTAATTTTTTTTGATGATCATTCGAGCAAAACTGCTTGATTTTTTCAAAGAGTCAAAATAAAAAAAATTACACAAAACTTCTTTAAGTAATATTTTTTGATAAACTCTTTGACAAGTTTTGAGACCCTAAAATTGTGAATAACATAAAATGAAAAATTCGGTTCAATATCTTTTTTCTTGTTTACTGGGGATGACCACTTTTTCGGTAGGTATAACGCCGACTTCAGCAGGTCAGATGTACATTTACCAAGACAAAAACGGCAGTACTTTACTGACTAACCGTAAAAGTTATGACCATTCACTCAAAAAATTAAAAGTCACCTACTACCCGGATAGTAATATTCATAGTTATAGCAACTGGGGGACTTCAGAAGCTTCGGTTCTACCAAGCTATAGCAAAAACAAAAATGCTTTTGATCATATTATTAAGCAGGCAGCACAACAGCATGGTGTTTCGGAAGGATTAATCAAAGCCGTTATGCATACCGAGTCTGGCTTTAACGTAAATGCCCGCTCTCCGGTTGGTGCCCAAGGTTTAATGCAGCTTATGCCAGCTACTGCTCGTCGTTTTAACGTATCTAACGCTTATGATCCTCAGCAAAACATCTTCGCTGGTGCTAAATATTTAAGTTGGTTGCTCAAACGTTTTAACGGTAATACGCAAATGGCGCTTGCCGCTTATAATGCAGGAGAAGGAAACGTCGATAAATATGGCGGTATTCCCCCATTCCGTGAAACCCAAGATTATGTTCGCCGAGTCACAAGCCGCTACCAAAACTTATATTCTTCTGGTGTAGGCCTTTCTTCTTTTAGCAATTCGAGTATTTCTGCCCAAGCGATAAACCAGCCAGCCATACCGCACAGTACTTCGACGCAAGTCTCTGCTCAGCCTATAAAGTATTCTTCCTCGCGCCAAATCGTGACATTGCCAGATGGTACATATACAGACGCACCTACGGGAACTTATGTCACCAATAATGCAACTGCTATTGCACATATCCGGATTGAGTAAGCTTAAAAGGCCTCATACCTTACGGTTACTTATTTAGCGGGTTCTATTATCAAAAAATTGTAATGATCTATTACCCCCACTGTCGTGTTCAGAGGGGCTCTCTAATAACTTGTTTAATTTAAATACATTCTTCGATCGCAAAGAATGTATTGATTCCTTATTTTTTTCTTGAATTTTTCCCCTAAGCGCCGCATATTAGCTGAGTGATTTATAATTTATAAATCAGATAATATTTTATTTATAAGAGGATTTTCTCAATGATGCGGATTGGTTTGTTTTTGCTTACCAACCTCGCGGTACTGGTTGTAGCTGGCATTATTTTGTCACTCTTCGGTGTCGGTAGTTACCATGGCGCGGGTGGCTTAAATCTAGGCAACCTTTTAGTCATCTGTTTTGTGTTCGGTATGGTGGGCTCTTTAGTCTCTCTATTCATGTCCAAATGGATGGCTAAGAAAACTACTGGTACAGAACTGATTGACCCAAATGCTCCTCGTAACCAAGCTGAAAGCTGGTTATTGCAAACAGTCGCTGAACTTTCTCAACGTGCTGGTATTAATATGCCAGAAGTTGGTATCTTCCCTTCATATCAGTCTAATGCCTTTGCAACAGGCTGGAATAAAAATGATGCCTTAGTTGCCGTTTCAAGTGGTCTACTTGAGCGTATGAACAAAGATGAGCTACGTGCTGTGCTCGCGCACGAGATCGGCCACGTTGCAAATGGTGATATGGTCACATTGGCACTCATCCAAGGTGTTGTAAACGCCTTCGTTATGTTCTTTGCTCGTGTAGTAGGTGACTTTATTGACCGTAATGTCTTTGGTCGTCAAGACAATGAAGCCCCAGGTATGGGTTATTTCATCATTACAATGGTTCTAGATATCGTGTTTGGTATTCTTGCCTCTGCCATTGTGATGTGGTTCTCTCGTTACCGTGAATACCGTGCAGATGAAGCCGGTGCGCGTTTAGCTGGTAAACAAGCGATGATTTCTGCTTTATTACGTTTGCAAGCTGAAACAGAGTTACCTGACCAAATGCCAAAAGAAATGAAAGCGTTCGCAATTGCGGAAGGTAAAGAACAAGGCTTTAGTTTAGCTGCATTGTTCCAAACTCACCCTACAATTGAACAACGTGTGGCAGCTCTACACCAATTAGATTGTCCATAAAACGTTTAATGTAAAAATAAAGCCTCCAAATGGAGGCTTTATTTTTTTGATTACATAGTTTGATAAAGTCCCCAAAGGTAACTTGCACCCCACCACACAGCTAAGCCAATTAATAGCAGTACAAACGCACCTAATAAATCGGGTATGTGCAACCATAACCAACTCACAACAGGGTTACGCCAGAATGCCGACTGTTGTTGCTTCTTTTCGAGCTTTTCATGTAAATACGGATGAACGACATGAATATCACTTTGGATCGCATATTCTTCACGTATATGCGTATGCACCACATCTAATGCTTTTCGACTGGGACGTATAAAAATATCGAAAATAGTCCCTGCAACCGGGACAAAACCGACTACAGCATCGACTACAGCAAGTTTGATCACTGGAGTGAGCTTATGCTGAGGCACACCTATTTGTTTAGCCTTATAAATGGCATAACACGTCAGTGCGAACCCAGCGACATCACCGGCAATTGGAATAGTACTTAAGGCAGCATCAGCGCCAATACCCTGCTTTGTAAAAGGAATACGGACCGCACTATCCATCATGGTTGCGAACTTGGCAAGATCTCGTTCTAGGGCGATAACCTGCTGCTGTGTTAATTTTTTTTCTTGAGGCATCAAAATCAAATATAAGAAGAAAAGTTAATCTTAATATACTTGATTTGATGCCCGTTTTTAAATTGTTTACTTTTAGGTTGAAGCTTTCGATTTAAACAGTGAACGTAATAATACGTACATGACCGGAATAAAAAACAGAACCAGCACAGTACCAAACATCACGCCACCTAAAATACTAATACCAATCTCTTGACGACTAACCGCACCAGCACCTTGAGCAAACACAAGCGGAATTACGCCTGCCCCAAAGGCTAAAGAGGTCATTAGAATCGGTCTTAATCGTAAGCTCGCACCTTCTAAGGCCGCCTGAATGGCATTCTTACCTTTTTCTTGCGCTAAGGCCGCGAACTCAACAATTAAAATGGCGTTTTTACATGACAAACCAATAGTCGTTAATAGCGCAATTTGGAAATACACGTCATTTGGCAAACCAAAAATATAAGAGAAAATCACACTTCCTCCTACACCAAGCGGAATAGATGTCATTACGGCGGCAGGAATACTTAAGCTTTCATATAAAGCAGCTAAACATAAGAAAATAAATCCAGCCGAAATTAAATATAACCACACCGCCTGATTAGTCGACTTCTGTTCTTCAAAAGATAAACCTGTCCACGCTAAACCAATATCTTTTTGTTGGTTAACAAGTTGTTCTACATCTTTCATCGCTTGGCCAGAACTGCTGCCACTCGCAACATCTGCTTGTAGTTGTAAAGCACTATATCCCATATAGCGTTTTACAATTTCCGGTGCCCCGCCCCAGCTAAAGTTGGCAAATGAACTAAACGGAACCATTTCATTTTGGTCATTACGTACAGACCAGTTATATAAATCTTCCGGTTTAGATCTAAACTCGGCATCACCTTGAATCATGACACGTTTAATACGGCCCCGATCAATAAAGTCATTTACATAAGTTCCGCCCCATGCGCTAGATAAAGTATTATTAATTGCCGATAGCTGTAGTCCATTTGCTAGTGCCTGTTTCTGGTCAATCTTAATATTAAGATTTGCCTTACTATTGGTTGACTGCTTATCAAAGTTTTCGAAAGTTGAATAATTTTTACTTTGAGCCTGCAATTGGCGGAAGGCACTATCTAGAAAATCTTGCCCTTGCCCATTCAAATCCTGAATCCATAAATCCAGACCATCTGTTTGACCTAAGCCATTAACTGAGGCAGGTAAAGTCACATTAATCTGTGCATTATTAAAATGACTAAAGTATTTCATTGCACGCTTTTGTATAGCCTCAGCCGAGTTTTCTTTTCCTGTTCGGACATCCCACGGTTTTAGAGCAATAAACCCTTGTGCCAAGTTTTGTCCTGTGCCCGAATAATTTCGTCCATAGCGGATTAAAACCAAATCTACGTTTTTATCTTCTTGAGTTAAGAAATATTGGCGGACTTGCTCACCAATTTTCTGACTTTGAGAAATTGGTGCGCTGTCTACGAGCTTAATTTGAACACTTAAAATCCCTTGGTCTTCTTTAGGAATAAAACCGCTTTTTAAACCGTTATAGAACAGCGTAAAAACGGCAATTAAAGCCACAAAAATCACAATAACTGATTTACTGTAATGAATACTCGTCTGAACAAGCTTGATATATTGATTTTTAAGTTGCTCAATCTTTTGGTTAAACCATACGGCCCAGCGCTGAGGTTGAGGGTTTGGTTTTAAAATTAATGCACATAAAGCCGGTGTTAAAATGAGCGCAACAATAAGGGACAACGCCATAGCGGCAACTAAAGTAATAGAAAACTGACGGTAAATCACCCCAATTGAACCGCCTAAAAAGGACATTGGAATAAAAACAGCAGTTAAAACCAACGTAATTCCGACTAAGGCACCACTAATTTCTCCCATCGACTCAATAGCAGCTTCTTTAGGAGATAAGTGCTGTTCATGCATGAGCCGCTCAACGTTTTCTACGACCACGATTGCATCATCGACCAACAAACCAATCGCGAGTACCAGCGCAAATAACGTTAAGGTGTTAATACTAAAACCAAGCACATATAAGACCGCGAAAGTTCCTAAAATTACAACTGGAACGGTAATACTCGGAATGAGCGTAGCACGCCAGCTTTGTAAGAACAGGAACATGACCAAAATAACCAGAATAATCGCCTCTACCAGAGTCTTTACTACTTCCTTAATTGACTCTTGAACAAAGGGCGTATTATCTCGTGGATAAACGATTTTATAACCCGCTGGTAGTTTCGTTGTAAGCTGATCTAGAGTTTGGTGGATGAGCTTAGAGGTCTGAATTGCATTTGCACCTGAAGATAAAGAAATACCCAAACCTGCGGCAGGATAGCCATTAATAGTGTTAAAAGACTGATAGTTTTCTGCACCTAGCTCAACTCTGGCAATATCTTTTAAATACACATAACTCGCCGTTTTATTCGACTTCACGACAATATTTTTAAAATCCTCAACTGTTTTTAAGCGAGAACCTGCTGTGACTTTTGTATTTAAATATTGACCGTCAATTACGGGTAAGTCACCAATTGCCCCTGCGGCGACCTGAGTATTTTGTGCGGTGATTGCATTCGCTACATCACTTGGCATTAAATTATATTGTTTTAATTTATCCGGATTTAACCAGATACGCATGGCATATTGTGAACCAAATACATCAGTTTCACCCACCCCTTCAATACGGTTCAGGTTATCTACCACATGCGTAGTTAAATAGTCCGATAGCTCAATGTTTCCTGTTTTACCAGTCGAGTCATATAAGCCAATTACCATAAAAGTGTCACCCAGTGACTTACTTACCGTAACACCTTGGCGTTGAACTTCATCCGGTAAGCGACGTATTACGCCACTAATACTATTTTGTACTTGGACCTGAGCAGTATCCGGATTTGTTCCGTTATCAAAACTTATAGTAATTCGACTACGTCCAGATGAGTCACTCGATGAACTAAAATAGAGTAAGTGGTCAATCCCTTGTATTTGCTGTTCTAAAATTTGAGTAACACTTTGCTCAACCGTTTGTGCATCTGCACCACTATAGTTGGCCGACACAGTAATTTTAGGTGGAGCAATGTCTGGATACCGTTCTACAGGCAAATTCATAACCGAAAAAATACCGAAAGCCATAACAATGATCGCCAATACATTGGCAAAAATGGGGCGTTGAATAAAGAATTTAGATAGCATGGCTGCTCGGTATGATGTCGTTAATTAACAGAAGTAAATGCCGCTTCGAGACCTTGTGATGATCAACGAGCGGTATAAAAAAGACAAGTAGAATTAAACAATAAATGTAATTAAGACAAAAACAAAGCGTGATTGAATATTTCCAACAAACCAATAAAAAACCAGTTAACGAGTGTCACTTAAAATTCATGAATTCTTCATGATCATGTCAAACAAAGCACCGAAACTTGAGTCGTTTCAACTAAAACAATATGAGTAGAATTATGTTTAGAAAAGCACTTTTATGCTTAAGTTTAATTAGCTTGGTTGGTTGTAATGATGACGATAAAACTGAAACGACGCCAACCACGCCAGAATATCAACTTCCTAAAATTCTAGTAGTAGGACACCGCGGCGCTAGCGCTTTACGTCCTGAACATACTTTAGCTTCATATCAAAAAGCGATTGATGACGGCGCAGATTTCATTGAACCGGATCTAGTCTCTACAAAAGATGGCGTATTGGTTGCCCGCCATGAAAATGAGATTGGTGGAACAACCAATGTAAGCACTTTAAGTCAGTTTGCAGACCGTAAAAAAACAAAAAATATTGATGGCGTCGACTTAACCGGTTGGTTCACGGAAGACTTCACTTTAAGTGAATTACAGCAGCTTAAAGCGCGTGAACGTATTCCTGAGTTTCGACCAGCCAACACAGCTTATAATGACCTTTACCCTGTCCCAACTCTAGAACAAATCATTGAGCTTGCCGAAGCTAACTATAAAAAGACGGGGAAAATTATAGGTTTATATATTGAAACGAAACATCCGACTTATTTTAAAAATCAAAATCTGGCAATGGAAGATACTCTTTTAAAAACCTTAGCCAAATATAAATATACACGTGATATTGCACCTGTCTATTTACAGTCTTTTGAAGTGAGTAATTTAAAATATTTAAAAAATGAGCTTGATCTTCATAAGACGCTTAAACATGCACAAATTATTCAGCTATACGATTCAAAAACATCTCGACCAGCAGACTTCGTAGAGTCTGGTGACACTAAAACTTATGCTGATTTAGCCACAGCTCAAGGGTTAAAAGATGTTGCCAAATATGCAAATGGTGTAGGACCAAGTAAAGGTTACATACTGACCTTTAATAACGATGGCTCTTATAAAACTAGTACGTTTATTTCTGATGCACATACGGCTGGCTTAAAAGTACATCCTTATACTTTCCGACCAGAAAATAACTTCTTACCAGCGCCGTTAAAGTGCAGCCCAGATAAACCTGCTGAACGTTGTCCATCTGGTGCGTTAAAAGAGTTTGAAGCCTATTTCAAGGCAGGTGTTGATGGCGTCTTTACAGATGACCCAGCACTCGGTCGTGAAGCTGTCACTAATTTTGAAAAAGCTGCAAAATAACTCAATCTTCATAAAAAAACAGGGCAATGAATGCCCTGTTTTTTTTATTTATCAAGACTGTTATTGAAATATAAAGGAATCCACTGATACTGCTCAGCATTCACTTTATACACATGACCAATTCCCGGGAACGGTAAATGCGGGGCAGCTACCCATTGTTGCTTATTTGAAATTTCAGCAAACATTTTTAAACGAGTATTAATTGCCTGCTCTGAATTTACATCAAAATCTACCCCAGTTTTTGGAGCATCAAACTGTAAAGAATGTGAGTGGACAATATCACCAACAAAGACAATTTGTTGCCCTTTACTCTTCAAACGGAAGCTATGATGTCCCGGTGTGTGCCCTTGTGTATTGATTACTTCAAAACCTTGAATAACATCATCATCTTTAAAGGTTTTGAATGCTTTTTTTGCTTGATAAGGTGCAAGTGCAGCTTTTACGTTTTTAACAGTACCTAAATAATTTTCTTTTTTATCCGCTGGTACAGTTTTTTCATTTGCTGGATTTAACCAATAATCTGCTTCACGTTCATGAGCATAGATCGTTGCATTAGCAAATACGGCTTTTCCATTTTGAGCAATACCGCACACATGGTCTGGATGTAAGTGGGTCAATAAAACAGTTTTCACATTGGCAAGTTGATAGCCCGCTAATTCAAGATTTTTAGCAATTGAACCTAACTGTGGACCAAAACAACTCGCAGCTCCACTGTCAACAAGCGTCAAACTTTTACCATCATCAACTAAAAAGGCATTTACTGAAGTCTGAATCCCCTTCTCATTTACAGCAGCATATTTCGTTAAAATTTTAGTTTTTTCAGCCGGACTTAAATTTTTAAACAATTTAGGATCTAGATAAATAGTGCCATCGAGCAAGGAAGTTATCCGATAATTACCAAATTGATGATGGTAATATCCGGGTACTTGTTGAGCTGAAGCTGGTTCTGCATAGCTTATATGCAAGCTACCCATGATAAGTCCTAAGGCTACAAATAGTTTTTTCATCTCTTCTTCTCTATGGAGTTATAAAGTCAAAATCTTTAAAAAAGATTTAATATTTTTTTAAGGGCTGCACTATATAATGCATGAAAAGTGTCAAAAATATAAGTGAATGGATAGTTATTCTCCCTATAAAGGTAAAAGTGGCCTAAAGCGCATCTTGAACGCTACCAGTTATTCAATTTCAGGATTTAAAGCTGCTTATCAAAATGAAGCTGCATTTCGGCAAATTGTTTTAATTAATCTTGTACTCATCCCTGTAAGCTTTTTCCTGGATGTAACTCGCGGCGAACATGCCCTGATGATCATTGTCTGTTTATTTGCCATCATTGTTGAGCTCTTCAACTCTGCCATTGAAGCAGTGGTTGACCGAGTTTCACTCGAGAAACACCAACTTTCCAAAAATGCAAAAGATATGGGTAGTGCCGCTCAGTTTGTTGCACTTTCTATTATTGTCGCCACTTGGCTTATTATTTTATTTGGATAAAAAAAACCATGCTTATAAATAGATAAGCATGGTTGTAACAAAAGAGGAACTTCTAGCTGCTGTTCCTGTTTTAATTTCAGGGTTCTGAACTTAACTTATCCTTAAAATTACTGGAAAAATAAAAAAAATCCCTGCGAATGCAGGGATTTTTTTGGGTTAAAGCGTTGATGCGTTATTACATCATTCCGCCCATACCACCCATACCGCCCATATCTGGAGCAGCTGGTTTGTCTTCAGGAATGTCAGTAATCATACATTCTGTAGTTAACATTAAGCCAGCAACAGAAGCAGCGTGCTCAAGTGCAGAACGAGTTACTTTAGCTGGGTCAAGGATACCCATTTCTAACATATCACCATATTCGCCAGTTGCAGCGTTGTAACCGAAGTTACCTTCACCATTCTTAACAGCGTTGATAACTACAGATGGCTCATCACCAGCATTCGCAACGATTTGACGAAGTGGAGCTTCGATCGCACGGCGTAAAATGTTGATACCAGCTGTTTGATCTTCGTTAGCGCCTTTTAAGCCTTCAAGAGCATTTACAGCGCGAACAAGAGCAACACCACCACCAGCAACAACACCTTCTTCAACTGCTGCACGAGTTGCGTGAAGTGCGTCGTCTACGCGGTCTTTCTTCTCTTTCATTTCAACTTCAGTTGCTGCACCGATTTTAATTACAGCAACACCGCCTGCTAACTTAGCAACACGTTCTTGTAATTTTTCACGGTCATATTCTGAAGTAGACTCTTCGATTTGAGCACGGATTTGTTGAACACGCTCAGCGATAGCAGCAGCATCACCAGCACCGTCAACAATAACTGTGTTTTCTTTAGAAACAGTGATTTTGTGCGCTGTACCTAAATCTTGAAGAGTTGCTTGTTCTAAAGACATACCAACTTCTTCAGAAATAACTGTTGCGCCAGTCAAGATCGCGATATCTTGAAGCATTGCTTTACGACGGTCACCGAAACCAGGAGCTTTAACAGCACATACTTTGATGATACCGCGCATGTTGTTTACAACAAGAGTTGCAAGCGCTTCACCTTCAACATCTTCAGCGATGATAAGAAGTGGTTTACCAGTTTTAGCAACTGCTTCTAAAACAGAAATCAATTCACGAATGTTGCTGATTTTTTTATCAACAAGAAGAATGAACGGATTTTCAAGTTCAGCAGTTAAAGTATCTTGTTTGTTTGCAAAGTACGGAGAGATATAACCACGGTCAAACTGCATACCTTCTACAACGTCTAATGCGTCTTCGAAGCCAGAACCTTCTTCTACAGTGATTACGCCTTCTTTACCTACTTTTTCCATTGCTTGAGCAATAAGTTTACCAACAGTAGTATCAGAGTTAGCAGAGATTGAACCTACTTGTTCAATTGCTTTGAAATCATCAGCTGGTTTAGCAATAGAACGGATATTTTCAACTACAGTTTTTACTGCAATGTCGATACCGCGTTTTAAATCCATTGGGTTCATACCAGCAGTTACTGATTTGATACCTTCATTTAAAATTGCTTGAGCAAGTACAGTTGCAGTTGTTGTACCGTCACCTGCGATGTCGTTAGTTTTGCTTGAAACTTCACGAACAAGTTGAGCACCCATGTTTTCAAACTTGTCTTTTAATGAAATTTCTTTTGCAACAGTTACACCGTCTTTAGTAATGTGCGGCGCACCGAAAGAGCGGTCGATCACAACATTACGGCCTTTAGGACCTAAAGTCACTTTAACCGCATCTGCAAGTACGTTTACCCCTGCAATCATTTTTGAGCGAGCTGAATCACCAAATTTTACGTCTTTAGCTGACATATTAAACTCCGAATCTTTTTAAATACTGAATCTGATAATGAATTGAGTTATGGATCGATTAGCCTTCTAATACAGCTAAGATGTCTGACTCTTTCATGATTAAGAGTTCTTCACCATTTACTTTAACTGTTGTACCTGCATAAGTACCAAATAACACCTTGTCACCAACTTTAACATCCAAAGCACGTACGCCGTTATCAGTGATTTGACCATTGCCTACTGCAATTACTTCACCTTGAGATGGTTTTTCAGCAGCAGAACCTGGCAATAAAATACCGCCAGCAGTTTTGGTTTCTTCTTCTACGCGACGAATCACAACGCGATCATGTAATGGACGAATGTTGCTCATAATTAACTCCATCAGACTTAGTCTTTTTGATTAATCGTTATTGCTTTAATCCAGAGCAATAACAAAATATTTAGATGTCACTTTTGTGGGGATGAAAAAAATGGCTTCAAGGGGAAATAAGAAAAATTTTTCTCTTTTTTGAATATTTTTTAAACAATCAATTATTTAAGCTCATCTAAACCAAATCAATATGAAGTGAATTCAGCCAGCTGTTCATTAAACCAATAATGTCGAATTTTTCCTTCATTTGAAATTGTATTAAAGCTATTTGGATTATGATGATATAAGCGAGTAGAAGTTGCTGTACCTGCATGTATATCAAAAATAGGATGATCTATTTTTAAAGAATAAATCTGAGTTAAATCATATATAGCTGTTTTATGGAGATGCCCATGTAACATTCCAAATAGACCAGTTGTACTCCACTTTTCTAAAGCGATTTTGCCCAGAACCGGACAATCTTTTATTCCATGCTTATTATCAGGCGGCGTATAAAAGGGTTGATGAAAAACAACCAGCTTTATTTTATTTTTAGGTCCCCTGTCTAAACGCTCATAAGTAGCTTGAATTTGTTCAATCGAAATATGCCCACGCGTATGATAACGACGACGTATACTATTCACCCCAACAATATAAAAATGTTCAGTTTCTAAAGTCGGCTCTAATTCACCAAAAAAATATCTATAACGGGTAAATGGAGAAAAAAAACGGTTCCAGACATGATACAAAGGTATATCGTGGTTACCAGGCACCACAAGATAAGGAATATTGAGGCTATCTAAATACTGTCGACATTTAAAAAATTGTTCATATTTGGCGCGTTGAGTAATATCGCCGCTCACAACAATCACTTCAGGCTGTTGCTGAATACAAAAATCTCTTATTGCCTCTAAACACTCTTTTTTTTCTGTCCCAAAGTGTAAATCAGACAGATGTAGTAACATTCGGCACCATAATATTTAAAGCATTTTTTTCTACAGTGAAGTTTAAAGGAGGTTTCATCTCTATGATTTCTCCATCTAAGGCCACTGTGAGTTTGGTTTTCTTTGCACATTCAACAATGACATGATCAGCACAAAAACTATATACATCTTGTGCATCTTCAACTTTACCTTGAACCCATTGCCAAAGCATATTTAATAAACTCAGCTTATCACTTTTTGTAATTACAACTCCAGCGACTCTTCCCTGTGCTGCACATTCTGCAATTCTGAGCTTCATATCACATAGTTGCAATTGGTTATTTCCAAAGAAAATAAGCGGCGCTTTAACTGGATATTTCTTGCCATCTACAGTTATAGAAAGCTTCATTGATTTATTTTCTCTCAATAAAACATCTAAAGCTGAGGTATAGGCATGTAAAGGCAGTCTTCCTAAATATTTATTATAAAGCTCACGTTTCTTTATAAATAATGGATAAAGTCCTAGACTCGCATTATTTAGATAAATATGATCATTAATAACTGCTACATGTACTGACCTAGGTTTACCTGTTGCAATAACCTCTGCTGCCTCTAAAAGGTCTAACGGAATCTCTAAAACTTTAGCAACATAATTAAAAGTCCCTAAGGGCAGAATTCCCATGGGAATAGGAGTATTTTTAAGTTTAGTTGCAACCGCATTTAAAGTACCATCTCCTCCTGCCGCAACAACCACTCCTGTATTTTCATTTTGTGAATGTCGATGAATAACATTATTTATCAAATCATCAAATAATGTATTTTCATTTAATTCAAATACTTGTATTTCAAAACCATATTCTGTAAATACAGTCATGAGCTGCTCATAGACGTCTTCATGTTTTGAAGCATGAAATCCTGATTTTTCGTTATAGATGATTGAAAGAGGTTTCAAAGGCCGCATTTTATTATCGTAAAGTCAGTTCTTTATTCTATTTTGTATATAAAATCGCCTATTAAAAGTCTCTTTATGTAAATTTTGAATGAGCTTCATTTGTATAATCAATAATAATTCTCAAAAAAATTTTTCAAGCCTAATTAATTGATTTTAAATAAAATAATTTAGATAAATAACATACATATAACATAAAAATATAAAAGCAAAAACCTTATAAAAACATATAAACATATGATTTTAATTAAAAAATAAAGAAAACTCCAAATATCTGCTAGTTAGTCTTTAGTCTTATTTTTTTTATGATTTTATGCTTTAATACAGCCACTTTTTTATTTGATCTTTCATTGTATCCCAATGAATGACTTGTACGTTGTACATATTTTGAATAGGCCTCACCATGACCACAGTGAACGCACCAGAATTCGTTCGTCATCCTAAGCTTATAGCATGGGTTGAAGAAATTGCAAACTTAACCAAACCAGCAAAAATCGAATGGTGTGACGGAAGCGAAGAAGAGTATCAACGTCTAATCGACTTGATGATCGCTAACGGCACCATGCAGAAATTAAACCAAGAAAAACATCCTGGTTCTTATCTTGCAAATTCTGACCCATCTGACGTTGCGCGTGTTGAAGATCGTACTTACATCTGCTCTCAAAATAAAGAAGATGCTGGTGCGACAAACAACTGGGAAGATCCAGCTGTTATGCGTGAAAAATTAAATGGTTTATTTGAAGGTTCAATGAAAGGCCGTACCATGTACGTTGTTCCTTTCTCTATGGGTCCTTTAGGTAGCCATATTGCTCACATTGGTATCGAGTTAACTGACTCTCCTTATGTAGCTGTTAGCATGCGCAAAATGGCACGTATGGGTAAAGCAGTTTATGATGTATTAGGTACAGATGGCGAGTTTGTTCCTTGTGTACATACAGTAGGTGCTCCACTTGCTGAAGGTCAAAAAGATGTTGCTTGGCCTTGTAACCCAGAGAAATATATCGTTCATTACCCAGAAACTCGCGAAATCTGGTCTTTCGGTTCTGGTTACGGCGGTAACGCGTTACTTGGTAAAAAATGTTTAGCTCTTCGTATCGCTTCTGTCATGGGACGCGAACAAGGTTGGTTAGCTGAACACATGCTTATTCTTGGTGTAACTAACCCTCAAGGTGAAAAACACTACATCGCTGCTGCATTCCCGTCTGCTTGTGGTAAAACAAACTTTGCAATGTTAATTCCACCAGCAGGTTATGAAGGTTGGAAAATCGAAACTGTAGGTGACGATATTGCTTGGATTAAACCAGGTGAAGATGGTCGCTTATATGCGATTAACCCTGAAGCTGGTTTCTTCGGTGTAGCACCTGGTACAAATACTAAAACTAACCCGAATTGTATGGCAACTCTTCACAAAGACGTTATCTATACAAACGTAGCAGTAACTGACGATGGTCAAGTATGGTGGGAAGGTCTTTCTAAAGAAGTTCCAGCAAACTTAACTAACTGGAAAGGTCAACCTCACGTAAACGGCGAAAAAGCAGCACATCCAAATGCTCGTTTCACTGTTGCAGCAGGTCAATGTCCATCTATCGATGCTGATTGGGAAAACCCAGCAGGTGTTCCAATTTCTGCATTCATCTTCGGTGGTCGTCGTGCAGATACAGTACCTTTAGTTTCTGAAGCTTTCGACTGGGTTGACGGTGTATATAAAGCGGCAACTATGGGTTCTGAAACTACTGCTGCTGCTGTTGGTCAACAAGGTATTGTTCGCCGTGACCCATTCGCGATGCTTCCATTTGCTGGCTATAACATGGCTGACTACTTTGACCACTGGTTAAACCTTGGTGCGAAAGTAAGTGAAAAAGCTGAAGCTTCTGGCAACAAATTACCAAAAATCTTCAACGTAAACTGGTTCCGTCGTGATGCGGAAGGCAACTTCGTATGGCCTGGTTTCGGTCAAAACATGCGTGTTCTTGAGTGGATCATTGATCGTTGTGAAGGTCGTGCGAACGCTGTTGAAACACCTATCGGTTTTGTTCCAACATATGAAGACTTGAATTGGGAAGGCACTGAGTTCACTAAAGAACAATTTGACCTCATCACAAATCAAGATAAAGACCAGTGGGTTACTGAAATTGAAAGCCACACTGAGTTATTCAATAAACTTGGCGAACGCTTACCTAAAGCATTAAAAGAACGTCAAGCAGCTTTACTTGAAGCTGTAAAAACTGGCTTCTAATTACTCTATATAAAAAAGGTCGCCATGTGCGACCTTTTTTATTATGCGGCATCGTCTTTTAATCGACGTTCTGATGAATAGGCTTCTAAAACTTTTACCTGTTTTACATCAAATGCCAAACCTAATTTAGATCTGCGCCAAAGTATATCTTCTGCTGTGTGAGCCCATTCATATTCACACAAATATCTGACTTCACACTCAAACAAATCATGGCCAAAATGTTGACCCAATTGTTCTATAGCATTTCGCTCTTTAAGCATATTCCACACTCTTGTGCCATATGCATGAGCCCAACGGTTGGCAAGTGCGTCAGAAATTCTACTTACACGTGTTTTAATCTGATTGATTAAATCATCTAGTGTGGTCCAGTTTTCGGCGCCAGGTAATGCTTCATCTGCAGTCCACTCCTCTGCCATGTCATTAAAAAAAGGAGCCAGATGTTCTAAAGCAGCTTCGGCTAACTTTCGGTAAGTTGTAATCTTGCCCCCAAACACTGAGAGCAATGGTGTGGTTTTATCTTCTGCCTGTAGAGCCAAAGTATAGTCGCGTGTAATTGCAGATGGATTATCCGACTCATCATCACATAAAGCACGCACACCCGAGTACTGACTTACAATATCAGCTCGCGTCAACTGCTTTTTAAAATGTGAATTTGTCACTGTCAAAAGGTAATCAATTTCCACATCAGTAATCTCTACTTTTTGTGGGTCGCCTATGTATTCCTGATCTGTTGTACCAATGAGGGTATATTTTTCTAAATAAGGAATTGCAAAAACGATCCGTCGATCTTCGTTTTGCATAATAAAGGCCTTATGGCAGTCATATAATTTTGGCACAACAATATGACTTCCTTGTATAAGCCTAATTTGATAAGGCGAACTTAAACCCAGGTTTTTACTAATAATTTCTTCAACCCAAGACCCCGCCGCATTTACAATAGCTTTCGCACGTATCTGATAGAACTCAGCTCCGCTTTGTAACTCCAGATGCCACAATTCCTGTTGTCTATAAGCCTTAACACAACGTGTACGTGTAACGACTTTTGCCCCTTTCTCTTTAGCTTGTAGTGCATTTAACACCACAAGACGCGCATCATCTACAGTACAGTCAGAATATTCAAAACCACGTGTTATCGCTGGTTTTAAAGGGCTGTCTTCTTTGAAATAAATGAGATTTGATCCTAATAATTTTTCTCGTTTTCCCAAATAATCATAAAAAAATAGACCTGCTCGAATTAGCCATGCAGGGCGTAAATGGGATCGATGAGGCATGATAAAACGCATTGGTTTAATAATATGTGGCGCTTTAGCTAGCAATACTTCACGCTCTGCTAATGCTTCTCTGACCAGCCTGAATTCTTTATGTTCTAAATAACGTAGGCCGCCATGAATTAATTTGCTGCTAGCAGATGAGGTATGACTGGCTAAATCATCTTTTTCACATAAAAATACCGATAATCCGCGCCCTGCTGCATCATTGGCAATACCAACACCATTAATACCGCCACCAATTACGGCAAAATCATATATTTTTGAATAATCATTAGGTTGTACTTTCATTTCTCATGTTCTTTTTATTGTTGATCTTATAAAAATTAAAACATCAAATTGATGAAACAACAATCAAAAAAGTAGAATAATCAATTTTACATCCTCTAGTATTTAACTATCCATTGACTACCCTACTATTGAATTCAACTAGTTAAGAAAAAGCTCAATCCTCTGCCCAATTTTGGCTACGCTTAACTGCTTTTAGCCAACCTTTATAAATGAGTTCAGCTTGTTCAGAAGGCATTTTCGGTTCAAATACCTTTTCTATGGCAGATTTATTTCTTAACTCATGAAGATCTTGCCAAAAACCAGTGGCCAACCCTGCCAGGAAAGCTGCACCCAATGCTGTAGTTTCTTTCATTATTGGACGTTCTACCGGTGTCGTTAAAATATCGGCCTGAAATTGCATCAAGAAATTATTTTCCGTTACTCCTCCATCAACACGGAGTGTACGAAGCTCTTCTTCTGCATCTTGTTGCATGGCATCTAAAACATCTCGAGTTTGAAAGGCTATAGACTCTAGAGTTGCGCGGATAATATGTTCAATACTAGCCCCACGCGTCAGACCAAAAATTGCGCCGCGAGCTGTCGGGTCCCAATACGGTGCTCCTAACCCGGTAAAAGCAGGTACTACATATACACCATTATTATCCTTTACACGTGTTGCATAAAGCTCGGAATCCTTAGCATTCTTAATAACCTTTAATTCATCGCGTAACCACTGTACGCAAGAACCACCGTTAAATACGGCACCCTCTAAGGCATAGTTCACCTCACCACTCGCACCACAGGCAATAGTTGTGAGTAATCCATGCTCTGAACGGACAATCTTTTTACCCGTATTCATGAGTAGAAAACAGCCGGTACCGTAGGTATTTTTAGCCTGTCCCGACTCAACACACATTTGACCAAAAAGCGCAGCCTGCTGATCACCCGCGATTCCGGCAATTGGGATCCCTACTTCTTGTCCACTAATGGTATGTGTATATCCATAAACCTCAGATGAACTACGAACCTCCGGCAACATTGCTCTAGGAATGTCTAAAGCTTGTAAAAGCTTTTCATCCCACTCAAGCTTTTCAGTATCAAACAGCATGGTTCGAGATGCATTGGTAAAATCAGTGACATGGACGGCCCCATTAGTTAGTTTCCAAATGAGCCAAGTGTCCACCGTACCGAATAATAACTCTCCCCGCTCAGCACGCTCACGGCTGCCTTCAACATGATCCAAAATCCATTTAATTTTTGTGGCCGAGAAATATGGATCAATGACTAAACCGGTGGTCTTACGGATATATTCTTGCCAACCTGCTTTATACAATTGATTGCATATTTCGGTTGTTTGTCGGCTTTGCCAAACAATCGCATTGTAAATAGGTCTTCCTGTTTTTTTGTCCCAGACAATGGTGGTTTCCCGCTGGTTTGTAATTCCAATTGCCGCAACTTGTTCACTCTTGATGCCAGCTTGAGCCAATGCTTCGACCCATACAGCACTTTGAGTTGCCCAAATTTCCATAGGATCATGCTCAACCCAACCTGGCTGAGGGTAAATCTGGGTAAATTCTCTTTGAGCAATACTGACAACGTTCGCATCATGATCTAAAACAATTGCTCTTGAGCTTGTTGTTCCCTGATCAAAAGCGACAATATATTTTTTCGGGCAATTTGACATCTGAATGTCCCTTTCATTTTCCACACACATCTAGCCCATAATGCAAAAACATCATGCCTAACTGTATTTATTTAAAATTTTCTTTGGAATATATCATTATTTTTAAGTGGCATAGGCTTTCTTCGTCCAAACATTACCCATTCTTTATCAATTTTTTACTGCATGGAAAAAAGTAATAAGAAAAATATTGAAATTAGAAGATAAAAATATGCTGATCGGCTAATTTGAAATCACATAAATATTCAACTTATTCCTTTGCTTAAATAATAAACATTGTTTTACAGACATAAAAAAAATAAAGTGAAATACTCCTGTAGATAATATGTAAAAACGGAATAAATCTTCTCTTTTTTAGCATTCAACCCAAGCGAAACATGGAGCGAATCATGGTTGATCAACCTTCTACCGCAACAACTCCACATTCTAATTTAGATACAAAAACCCGTCTAAAATCAATTTTGGGCGGTTCTGCCGGTAACCTTGTCGAATGGTACGACTGGTATGTATATGCCGCATTTACGCTCTATTTTGCTCATGCATTTTTCCCAAAAGGAAGTCAAACCGCTCAACTTCTTCAAGCTGCAGCTATTTTTGCAGTGGGTTTCCTTATGCGTCCCATTGGCGCATGGATTATGGGGATCTATTCTGACCGTAAAGGACGTAAAGCGGGCCTTACACTTTCCGTTACTTTAATGTGTATCGGTTCGCTACTGATTGCTGTTACACCCTCCTACGAAAGTATTGGTGTATTTGCTCCATTGCTTTTGGTTATTGCACGTTTAATTCAAGGCTTAAGTGTAGGCGGTGAATATGGCGCAAGTGCAACGTATTTAAGTGAAATGGCAGAAAAAGATCGTCGTGGTTTTTTCTCAAGCTTTCAATATGTCACTTTAATTGCAGGACAGCTTACAGCTTTATGCGTACTACTTATCTTGCAAATGATACTCACCGAAGAACAACTGCATGACTGGGGATGGCGTGTTCCGTTTTTCATCGGAGCCCTTTTAGCTATCGTGGTGTTCCGTATTCGTCGTGGCTTATTGGAAACTCAATCCTTTAAAAACGCTCAAGCAGAAACAGATCAGCCGAAATCAGGAATGTTTGCTTTATTTAAACATTACCCTAAAGAAGCCTTCACTGTATTATTCCTAACTGCTGGTGGTACTTTAGCTTTTTATACTTACACCACCTATTTACAGAAATATTTAGTGAATACTTCTGGTTTTACCAAGCCTGAGGCTACTCAAATTACCACTTTAGCCTTATTCATCTTTATGTGCTTACAGCCATTGGCAGGTGCCTTATCAGATCGAATTGGCCGTAAACCGCTTATGATCGCCTTCGGGGTTACAGGTGTTTTATTCACTTATATTTTGTTTGATACACTTGCAAACACGCATAACTACTGGACTGCTTTCTGGCTATGTTTAGGTGGACTGGTTATGGTAACCGGCTACACATCAATTAATGCTGTAGTGAAAGCTGAACTTTTCCCTGCACATATTCGAGCTTTAGGTGTCGCATTACCTTATGCAATTGCGAATACTTTATTTGGTGGTACAGCCGAGTTTTTTGCATTAAGTTTTAAAGAAGCCGGGCACGAATCTTGGTTCTTTATTTACGTCAGTATCATGATTTTCATTTCATTGCTGATTTATATCTTCATGAAAGACACCAAACATCATTCAAAAATTAAAGAACATTAAAATCCTTCAATTAGAGCTAATATCATAAGTGAATGTTAGCTCTAACTTAGTGAATAAGCTCCAACAACGTTTCTATTTTATGAGATACTTCATATAAGAAAATAAGGACGATACTGATGAATAAAAGTATTCTATGTTTGGCATTAAGTAGTATGTTCATTTTAACTGCCTGTCAGACTACGCCTCGACAATATAATGGTTCAACTGGCTACCAGATTGAAAACCAAACAAAAACTTCAGCGACTTTAGCTTACACTTTAGCTGGTCGTAGTAACCAGCAACTTGATGAGCGTAAATTGCAACGCGCTTGTCAAAATGTGTTAGGTGCTCAGAAAGTTTATAAATTATCAATTTTAAGCATCAATGAAATTCCTAATCCAGCTAAAGATGAGCATTACGGAATTCAACTAGGTGAAACCCGCGCTTCTTTTGGCTTATCAAATACACCTAGCTTAAATAATGGTGAAGATTATGCGACACGCCAAGCACTTGAAGCACGTCCAAGTACATTAAAAGTCGTTCGTTATACTTGTTCATAACATAAAAAAGACGCTGTTTTTACAGCGTCTTATAAAAACTTACATTTCTAAATTCTTTCGCTTCATCCAGATCTGGCCAAGTTGTTGCACTTCTTTCTTCAATTTTTTCATATTTTGGATGACTAAAATTTTTAACACGGCTATCTGCTACCCATACTTCTGGTGCAAATTTTAAAAATTCGTCTAAGAAAAAGCGATTACATTGGTCATATAACACATCGGCAGCAAGTAAAACATCGACTTGTTCAGCCTTATATAAATCATCCAAATATTCGAGTTCTACATCATTAAGTAAAGCATTTTCACGACAAGCATTTAAACTGACCTGATCAATATCACAGCAGATTACGCGTTTTGCTCCTGCCATTTTTGCAGCAATTGCCACTACACCAGAACCTGCTCCGAAATCTAACACCACTTTATCTTTAACATGGTGCGGCTCTGCAAGTATCCACTGAGCCATCGCCAAGCCTGATGCCCAACAGAAAATCCAATACGGCGTGTCATTCCAGATACGGCGAATAACTTCGTCATCCAACCGATCAGTTGGAAAAACAGGTGGAATCAACCATAAAGAAATTGGAGTTTCTGGCAACTGTTGTGCCATTAATTCACAATGAGGAATGACTTCATGTAAGGCTTGAAGTAAATGTTCAGGGGCTTTGGTCAATTGAAAGGTGCAGCTCATAAATAAGCTCAACAATTTATAATTACTATTTGATCATCTGCATCGCGAGCAAGACTAAAACAGTAGCTTAAAGCATGATATTGGCTAGTTACTAAAAATACGTTAGTTCAATTCCACTGCTTTAATTAGTGCAACCGTTTTGGTCTTGCGTAGCATTCGCTACTCATCCCGAAAGAAAAGTAACATACGAGCTCCTAACATTTTCCTTAAACGGTAGGATGCTGCCGTGAATAAATTAAATTAACCTAAAGCTTTTTCAGCAGCTTCTACAGTTTGACGAATCAAAGTTGTAATGGTCATTGGACCAACGCCACCCGGTACTGGTGTATAAGCAGAAGCAATTTCTTCAATACCTTGTAATTGAATATCGCCTACACCACCGCCATCACGTGGATGGAAACCAGCGTCAACAACAACTGCACCTTGTTTAATCCAATCTTTTTGAATAAGTTCAGCTTTACCTACAGCACCAACAATAATGTCAGCTTGTTTCACAAGCTCAGGTAAGTTTTGTGTACGTGAATGACAAATCGTTACTGTCGCATTTGCTTGCAACAACATCATTGCCATTGGTTTACCTAAAATTGCTGAACGACCAACTACAACCGCGTGTTTGCCAGCAATTTCGATATTGTTTTCTTTAAGAATCGTCATAATGCCAGCAGGAGTCGCTGAACCATATGCAGCTTCACCCATTGCCATACGGCCAAAACCAAGGCAAGTTACGCCATCTACATCTTTTGCTAAAGAGATTGCATCAAAACATGCGCGCTCATCAATTTGTGCAGGAACTGGATGCTGTAAAAGAATACCGTGAACATCTGGATTGGCATTAAGCTTTTCAATTTCAGCTAATAATTGTTCTGTTGTGGTTTCTTGTGGTAATTCGATTTTTAATGAATCCATACCTACTCGGCGGCAGGCATTCCCCTTCATACGTACATAAGTTGCAGAAGCACCATCATCCCCAACCAAAATAGTCGCTAAAATTGGGGTACGACCTGTTTTCGCTTTTAAAGCTTCAACACGTACCAACAAATTTTCTTCAATTTGCTTTGCTAATGCACGACCGTCTAAAACCAATGCCACAGCACATCTCCAAGGTAG
+>3_2#NODE_11_length_39995_cov_63.1687_ID_21
+CTGCCCAAACTGGTGCAGGCGGCGAACGGGGCAGCCCTCGCGCAGCTTCAGGTCAAGCTGTCGAACAACGACTACACCCCCGCCCGCACCCTGCAAGACGCCCAGCTCGCGCTCGCCAACGCCCAGCGCACCCTGAACGACGCGACGCGGGCGAGCAGCACCGGGGTCAGCGACGCCTACCGCGCCGTGCAAAACGCCCAGCAGCAAGTGAACATCGCCCGGCAGCAGGCGACCAACGCGCAGACCGCGCTCACCCAAGCGCAGGCCCGCCTCAAGGCCGGCACCGCCGCCGCCGTCGAAGTTCAGCAGGCGCAGGTGCAGGCGCAACAGGCGCAACTCGGCGTGCAGCAGGCGCAAGACGGCCTGTGGCAGGCGCTCGCCGCGCTCGGGGCCGCGAGCGGGACGGACGTGACCGGGCTGGTGAAATAGTGGGGACTGGTGAAATAGTGGGGGCTGGTGAAGTAGTGGGCGGCCCTCTTCAGATGGCGCGGCGGGTGACCAGAGGAGCCGCGCCGCGCCTGGCCGGTGCCCTGCTTCTCACGGCGCTGCTTGCCGGGTGCTCGCCCAAGACCGAAACGAAAACCAACGACCTCGACGCCGCGCTTCCCAAGACGACCACCCTCAGCGTGCAGACGGTGACGGCGAGGGCGGGCACGCTGACCGCCCAGCGCAGCGCGAGCGCGACCATTCAGGCCGAGCGCGACAGCCAGGTGGCGACCCAGTCCTCCGGCGCCGTGCAGAGCATTCCCGTGAGTCAGGGCGAGGCGGTGGCGAAAGGCGACGTGCTCGTCAAACTCGACGACACCGCTCAACAGCAAGCGCTCGACAACGCCCGGCTGCAACAGCGCCAGGCCCAGATCAGCCTCGACCAGACGCGGCAAAGTACGTCCCAGGGGACCGGCGCCCTGCAGGCGAGCGTGACCTCGGCGCAGGCGGCGCTCGCGCAGGCCGAGCAAAACGCCCAGAGCGCCGAGAAGCTCTACGGCCTCGGCGGCATCAGCCTCGCGGACGTGCAGGCGGCCCGCTCGCAGCTCGCGCAGGCCCAGGCGCAACTCGCGCAGGCCCGCAATACCCTGGAGCAAAACGGGCGCAGCGCCGGCAACTCGGTGCCGCTCGCGCAGGTGCAGCTCGACACGGCCCGCACTGCCGTGCGCCAGGCCGAGCAAAACCTCAGCCGCACCGCCGTCCGTGCCCCCTTCGCTGGTACGGTGGCCGACGTGCTGACCGAGGTCGGCGAGTTCGCCGGGCAGGGCACCCCGGTCATCCGCCTCGTGGACCCCGGCAGCGTCCGCGCCCGCGTGGGCGTGCCCACCGCCGACGCCGCCGCGCTCACCGAGGGCGTCAAGTTCAACCTCAGCTACGGCGGCAAAAGCTACGTGGCGACGGTGGTAGACAGCTCGGGTATCGCCGGCAAAGACCGCCTGGTGCCGATTACCGCGACCATTGAGGGCGGCAATGCTCTGCCCGTCGGCGCCGCCGCCCGCGCCAGCTACCGCGCCACACTCGGCAGCGGCCTGCTGATTCCGGCGAGTGCCCTTCAGGTGGAAGGCGGTGAAAACGCCGTCTACGTCGCCCGCAGTGGCAAGGCCGAGCGCGAAGTCGTGCAGGTCGTCGCCGAGAGCGGCAACCGGGTGGTGGTGTCGGGCCTTCAGGACGGCGACGCGGTCATCAGCCCCCTGCCCGCCGGGGTGCAGGACGGGGCGAAGGTGGTGGTGAAGTGAGGGCCATAGCGCACAGAGTCGAGGGCCGGGGGGGAGAAAACCCCTCACCCCTTGCTGCGCAAGGCCCGCTGCTTCGCAGCTTTGCAAGTCTCCCCTTGGGAGAGGGTCAACAGCGCAAAAACCTTAAGCCTTCTATGACCCTCGCCCCTTGCGGGAGAGGGCCTGCCGCAGGCAGGGGTGAGGGGGCCAGCCCGTCCTGTCTTTCCCCACACGCCCCCCAGGTCACCCCATGAGCACCCACTTCGACGAAGCCGAATTCAGGTCCGGCGGCACCCTGCCCGACGGCACACCCGAGCCGCAGATTCACCCGCTGGTGCGCTTCAGCGTCAAGAACTACGTCTTTTCCATCGGCATCTTCGTGATGGTGGTCCTGCTGGGGCTGGTGGCGACCTTCCGGCTGGGGGTCGAGCTGCTGCCCAACTTCGAGGTGCCGGTGCTGGCGGTGAGCACGTCCTACCCCGGCGCCAATCCCGACCAGGTGGACCGCGAGGTCAGCCGCCGGGTGGAAGACGCGGTGAGCACGCTCTCGGGCGTCACCGACATCAACACGACCTCGGTCAGCAATCAGTCGGCGGTGGTTATCACCTTCAGCGACTCGACCAACATTGACTCGGCGGCCAACTCGGTGTCGCAGGCGGTGGCGGCGATTCGCGGCACCCTGCCCGACGGCGCGGAGGCTCCGGTGGTGCAGAAATTCGACCCCAACGCCCAGCCGATTCTGACGCTGGCGCTGCTCGGCGGCGCGGCGCGGCCCAGCGAGGTGACGACCTTTGCCGAGGACACGCTGGTGCCCCGCCTGCAACGGGTGGAGGGCGTGGCCGACGTGACCGTGACCGGCGGGCCCGAGCGGCAGGTGCAGGTCTTGCTTGACCCGGCGCGGCTGCAAGGCTTTGACCTCGCGCCCGCACGAATCAGCGGGGCCATCGGTTCCTCGGCGCTCGACCTGCCTGCCGGGACGCTCGACCGGGGCGGCTCGACCACCTCCTACAGCACCCGCAACACCCCGCGCAGCGCCGCCGACGTGGCGCGCATCGTGGTGGACCCGTCCACCGGCCTGCGCGTGAGCGACGTGGCGACGGTGCGTGACGCCAGCGCGGCGGCCAACAGCTACGCCCGCGTCAACGGGCAGCCCGCCGTGCTGCTCGGCGTCCGCAAGGCGAGCGGCACCAACTCGGTGGCCGTGACCGACAACGTGCGCGCGGCGATGGAAGCCCAAAAGCTCCCGCCGGGCTACCGCCTCACCCTCGCCAGCGACACCACGACCAGCACGCGGGCCACAGTGAACGACACCTTCCGGGAATTCCTGATTGCGGTGGGCGCGGTAGGTCTGATTTGCCTGCTGTTCCTGGGACGGCTCAACACCGTGTTCGCCGTCATTCTCGCCATTCCGATTTCCATCAGCGCCGCGCCGCTGCTCTTCGGGACGCTCGGCTTTACCTTCAACATCATCACGCTGCTCGCCATCATCGTCGCCATCGGCATCGTGGTGGACGACTCTATCGTGGTGGCGGAGAACGTGCAGCGCTACCGCGACCTGGGCTACTCGCCGCTGCGGAGTGTGCTGCTCGGCGGCTCGGAAGTGTTTTCCGCCGTCACCGCCGCGAGTTTCTCGCTGCTGGCGGTCCTCATTCCGCTGAGCCTGATGCCGGGCATCCTGGGGCAGTTCTTCAAACAGTTCGGGCTCGGCATCGCCGCCGCCATCGTGCTGAGCTGGCTGGAAAGTCTGCTGTTCCTCACCGTCCGCATGGCGTACACCCGCGAACCCGCCCGCATCACCTGGGCTGACCTGCCCGCTGTGCTGCGCCGGCTGCCGCTCACTTTCCGCGAGTCGCTGAGCGGCGTGAAGACCTTCTGGGGCCTGCTCGGGCTGGCGCTGGCCGGGGCCGCGACGTACTTTGGCCTGCACCGCGCCGGGCTGCCCGCTGCCGCCGCCGGGGTGCTGTGCGTCCTCCTCGCGCCGGTCGTGCTGACTGTCGTCCGCTACCTCCTCACGGTGCTGTATGCCCTGCTCGAAGCGCTGACCGAGACGCTCCACACCCTCACGCTGAGTGGCGTCAACCGCGCGGCCAAAGCCTACGCCCGCTCGCTGGCAGGCGCCCTGCGGCGGCCCGGCGTGGTGATGCTGGTCGCGGGCCTCTTTCTGCTCAGTGCGCCGCTCGCCCTGCGCGGGCTGGGCTTTGCCTTCGTCCCGGCGAGCGACAGCGGCATTGCGACCATCAGCCTGACCCTGCCGGTGGGCACGCCGCTGGCCGTGACGGATGAGCTGACCCGGCAGGTGGAAGACAAGCTGCTCGCGCACCGTGAAGTCAAGCTGGTGCAGACCGCTTCGGGCAGCAGCGGGGTCCTCGGCGGTGCTAACGCCAACACCTCCGACCTCACGCTGACGCTGATTCCCAAAGCCGAGCGTCCCGGCATCGACGAGTTGCTGGAACGCTACCGCCGTGAACTTGCCCCGCTGGTCGCCCGCTACCCCGGCACCGAATTGCTGGTGGCGGGGCAGGCGGTGGGGCCGGGCGACAGTTCGGACATCTCGCTCGCGCTCACCGCCCCGAGTCAGTCGCTGCTCGAAGAACGCAACCGCGCGGTGGTCCGGCTGCTGAGTGCCGACCCCAACATCCGCACGGTGAAAAGCAGCCTCTCGGCCACCCGGCAGGAGCGCACCTTCGTTCCCGACCCGCTGCGGCTGAGCGGCACGGGCCTGAGTGCGAGCGACGTGGCGCAGGCGCTGCGAACCTACAACGACGGCACCGTGGCCGGGCAGGTCCGCGACGGCGACCGCAGCGTGGACATCGTGGTGCGGCTCGACCCCGCGCTGGTGTCGGGCGAACAGAGTCTGCTCTCGCAGACGCTCTACTCGCAGGCCCTCGGCGCCAACGTGCCGCTCTCCAGCCTGGGCCGCTTCGAGGTCGCGCAGGCGCCCGCCACGCTGCGGCGCTTCAACAAGGCGTACACCGCCACGCTCGACATCAACCTCGTGTCGGGCGGTCCCAACCCCTTCGCCTATCAGAAAGACGTGCAGCAGCGCGTCGAAAAGGCCGGGCTGCTCGCGGGCGGCGTGACCCTCGGCAACGCCAACTCCTTCGGCAGCGCGGGGCTGACCGGCGACCTGCTGTTCTACGGCCCGATTCTGATGGTGGCGGCGGTGCTGCTCACTTATCTGGTGCTGGGCAGTCAGTTCAACTCGTTCCGTTACCCGATTTATCTGTTGCTCCCGATTCCGCTCGCCATCGTGGGGGCGCTGTGGACGCTGCACCTGTTTGGCGTCAATCTGGACGTGATTACGGTGCTGGGGATGGTGATTTTGCTCGGCCTCTCCACCAAAAACTCCATCCTGTACCTCGAATTCGTGACCGAACGCGCCCGCGTCCTGCCGCTGCACGAGGCGCTGCTCGAAGCCGCCGAACTGCGGTTTCGCCCCATCCTGATGACCACGCTGACGGTGCTGGTGATTTCCATTCCCCTCATCCTCGGCCACGGCGAGGGCGCCGAATTCCGCCGCGGCCTGGGCATCGTGATTCTGGGGGGCGTGGTGACGAGCACCCTGCTGACCTTCTACGTGGTGCCGAGCGTCTTCTGGCAGTTCGAGAAAAAGCGCATGGCCACGCCACAACCGAAATTGGAGCCGGTGGCTGGAGACTGAACCCTCGCTGAAACCGTGAAGAAATGGCGCATGTGCGGCCCTCTCCTACTAAGGAAGAGGGCCGCACGCTGTAGGGACGGGCTCATAAAGTTCTCTAAAGCATTTGACAGAAAAAGACACCCTCACCCCTGCCTTCGGCAGGCCCTCTCCCATCAAGGTAGAGGGTCAAAAATGCTCTAGAAAAGGCGAATCAGTGAACTTTATTGCGGCTGCAAGGGAGCCAGTACAGCCCGGCGTTGGCCTCGTTCGGGTTGGTCGAGCCCCAGCACCAGCCCTTGGCCCGGATGCGGCGCAGCGTGGCGTCACGTTTGTCGCACATGCTCTGGGTGCTTTTGGAAGAGTGCGCCGACTGGCAGACCTTCTCCTGGGCGATGGCCTGATGAATCAGCGACCGGACGGCGGGGTCGTGGGGCTGGTGGCTGGTGCCGATTGCGCCTGCACCAGCGGTTGAGGTGAGCAGGGTCGCGGCGAGCAAGAGGGGACGCAGAGTGTTCATGGCTGCACTGTGCGGGGGCAAGGTTGGAGGCGCGTGAAAAGTGACTTCAGGGGTTAGCGACCGCCGCTCATGTGCGGGAGGTCTTCCCGTTCGGCCCTCAGCCCCCTCGTTACTGCTCACGGAGGGGCTTTTGCATTTGCCCCCCGCCGTGTATATGCATAGAATATTCAGAATGCTGGGCAAGGAAATCGGAAAAGACCAACGACAAAAGCGCATTCAGGACATCATCCTGCGGGAGAGTGTGTCCACGCAGGCCGAACTGGTCAAGCTGCTGGCGAAAGAAGGCGTGCAGGTCACGCAGGCCACCGTCAGCCGCGACATCAACGAGCTGCGGCTGGTGCGGGTGCCCATCGGCAAGGGGCGGCACCGCTATGCCCTGGCGCAGTACGGCGGCGACAGCGACATCGAGGAGCAGCTCGCCCGCCTCTTTCAGAGCTTCGTGCAGGACGTGGACCGGGGCGAGAACATCCTGGTCATCCGCACCGCCGACGGGCACGCCTCGGGGGTCGCGCTGCTGCTCGACCGCTGGAAGCGCGACGACATCGTGGGTACGCTGGCGGGCGAGGACACCATCATGGTTGTGGCCCGCTCCACCCATGACGGCGAGAGCCTGATGGAAGAATTCAACGCGCTGATGCTGGGGTAACAGCTCTCACAGCCCAGTCCAGAGCACAAAAAAGGCCCCCTTCCACACCTGGGAAGGGGCTTTTTCCTGGGCTGTTTCGGGCCGCTTATTCTTCGCGCAGCACGTAGCCGACGCCGCGCACCGTGTGAATCAGACGCCGCTCTCCGCCTTCTTCGAGCTTGCGGCGCAGGTAGCCGATGTACACGTCCACCACGTTGCTGCCGCCGGTATACTCGGGCCAGACCTTTTCCTCGATTTCAAAGCGCGAAAAGACCTTACCGGGGTTGCGGGCGAGCAGTTCGAGCAGTTCGAATTCCTTCGCCGAAAGTTCGACCCGGCGTCCGCCCCGGAAAATCTCGCGTCCATCGAGGTTCATCACCAGGTCGGCCACCCGCACTTCGCCCGTCACGGCGGGGTTGACTCGCCGCAGATGGGCGCGGACGCGGGCCAGCAGTTCCTCGATGGAAAAGGGCTTGATGAGGTAGTCGTCGGCGCCCGAGTCCAGGCCCTCCACCTTGTCCTGAATGCCGTCCTTGGCGGTCAGGATGATGATGGGGGTGTTGCTCGTCTTGCGGATGCGGCGGGCGACCTCAAGGCCGTCGAGGACCGGCAGCATCAGGTCGAGAATCACCAGATCGGGGTTGACTTCGCGGAATTTCGACAAGCCGGTCACGCCGTCAAAGGCCACCTCGGTGGCGTAGCCCTCGGCGGCCAGTTCCAGCTCGATGAAGCGGGCAATATCTTTTTCGTCTTCGATGACGAGGACGAGCGGCTTGCGTTCCATGCCCGCAGTGTAATGAGTGCTCTCATGAGAAGGCGGCGCCCCGTCCTTAAGTTCTATTCATCACAAATGCTGGCGGGGGCGGGCAGCGCTGGGCCGTCACGCGGGTCACAGGTGAGCGCCGTACACTGCCGGACGTGACCACGGGCCGTTCCACTTCTTCGCCTTCCGCCTCGCCGGGCCAGGGCACGTCGGCGCAGGACCCGGCCCCCCGGCGCTGGCTGCTGCGGCCCTCGTCGCTGCAATTGCGGCTGACGTTGCTGTACGCGGCGCTGCTGGCGCTGATGCTCGCCTCGGTGTACGGTGCCGCGCTGGTGCTCATGCGCAGCAGCTTGATTACCGGGCTTGACGAGGGGATGCGCAACACTTACAGCCAGTTCAGCGAGCTGGTGGCGCAACTTGCCCTTGACTCGCCCACCACCGAGCAAGAGCGCGACAAGGAAGGCGTGCTGCCCCGCGCCCGCACGCTGTTTCCCAACGACGCGATTCAAATCGAGAAGCTGCCTTTCGTGGACCACGACCGGCTCCTGACCCGCCTGAGCGACGCCCAAAAGCCCGCGCAGCAGCGTCAGGAATTGCAGGTGGTGCGCTCGCAGCTCACGAAGTACCGCTACCCGGTCACGGTCAACCGTGCTTCTCCGCTCGAACTCAGCGACGCCGAGCTGCTCGACCTTATCGAGTCGCCCACGGGCCGCATCTTCATCGCCCGGCAGATTCGTGAGCCCTACAGCGACAAGACGGTGCCCTACCGCATCCTCGTGACATTGGCGGAGGTGCAGTACGCGCCGCGTCCCCTCGCTTCGCTACGCGACGGCGACGTGACGGTGGATTTCATGCCGCCGCCGGTGCTTTCGATTATTTACGTAGGGCGCAGCGTGGCGGGCATCGAGGACACGCTGGGGCGGCTGCAACGGGTGTTCGCCATCGTGATGCTCTTCGGTGCTCTGCTCGCGGGCACGCTGGCTTACGTGCTGGCGGGCCGGGCGCTGCGGCCCCTGCAAGAAGTGCGCCAGGCTGCCGAGCGCATCGGGGGACAGACGCTGACCGAGCGCGTGCCCGAGCCCCAGACCGGCGACGAGGTGCAGGCCCTCGCCCGCTCGCTCAACGCCATGCTGGGGCGGCTGGAAGCGAGTTTCGAGGCGCAGCGCCGCTTTACCAGTGACGCCAGCCACGAGCTGCGGACGCCCGTCACTGCCATCAGCGGGCACGCGAGTTACCTGCTGCGCCGCACCAATCCCGGCGGGCAGGAGCGCGAGAGCCTCAACATCATCCGTTCAGAATCCGAGCGGCTGACCAACCTGATTACCAGCCTGCTGCAACTCGCCCGCTCCGACAGCGGGGCCCTGACCCTGAACCCCGCGCCGATTTTCTCGCGCCTCTTTCTGGACGACGTGAGCCGCGAACTCGCTCCGCTGGCGACCGGGGGCTCCGAGCTGCGGGTCAGCGGTCCCGACATTCCTTTCGAGGGCGACCCCGACCGGCTGCGGCAGGTCATTATCAACTTGGTCGGCAACGCGCTCAAGGCCGGGGCCAAGACGGTCACGCTGGAGAGCAGCTCGCAGGAAGAGGGCCGCGAGGTCCGCCTGAGCGTGCGCGACGACGGCCCCGGCATCCCGGCCGAGCACCTCTCGCGTCTCTTTGACCGCTTCTACCGCGTGGAAGACAGCCGCAGCCGCGACCAGGGCGGCGCGGGCCTGGGCCTGAGCATCGCGCACAGCATCGTGGACGCCCACGGCGGGCGCATCTGGCTGGAGAGCGAGGTCGGGCGCGGCACCGTGGCGCACGTCCAGCTCCTGGTGGGCGACGTGCCGGTGCTGGACGAAGACGACGTGCCGTAGGGAGACGGGGGAGAGGCAACTTCCCAGCTTCTCCATTGGTACCTCTGCGCCCCCGGCCACCTTCCCCCGCCCGCGCCCGCCCTAGACTCGGCGGGTGCGGCGTTTTCCTGTCCTGTTTCCTCTGCTTTTGCTGCTGGCGCTGACGGCCTATCTGCTGCCCGCCCGGACGCCGCAGAACGTGGAGGCCCCGCCGCCCGCCGCCACGACGACGCTGCCACAGGCGCTCCCGACCGCCGAGCGCGAGCTGTTCGCCTCGCTGCGTCCGGCGGTGGTGCGGGTGGACAGCGTGAACACGGCGACGCGCACCGGGGGCCTGGGCACCGGCTTTTTCATCAGCGGGGAGGGGCAGGTCCTGACCGCCTACCACGTCGTCAAGGCGGGGCAACTCTTCGCAGTGACGACCCTGGCGGGCAAGACCTACCCGGCGCGGGTCGCGGCTTTCGACGAGGCGGCGGACGTGGCCCTCTTGCAAGTCGCGCGCGGCGGCCCCTTTCCCTACCTTGAACTGGCGAGCGGGACACCGCAGGTGGGCGAACGGGTGCTCGCCATCGGCAACAGCGGCGGCGACTTTTTGCAGCCCCGGCGTGGCGAACTGCTGCGGTTGAACGCCGAGGCGGGCCGCAGCGATTTCCCCGAGGGCACGCTGGAAATGAACGCGCCGCTCGCGCAGGGCGACAGTGGCGGGCCGATTTTCAATGAGCGCGGCGAGGTGCTCGGCGTGGTGAGTTACATCCGGGTGAGTGGCGACGGCGTGACGCGGGCGAGCTACGCGGTGCCGGTGCCGGGCGGCGGCGACCTCATTCGCGGCCTGCAAGCGGGGGAGAGGCGCGAGTCGCCGCTGACGGCCCTCGTCGGCCTCGCCTTCGACCAGATGCACAGCGGCCTGACCGACCCGCCCGGCGCCGTGGTGCTGCGCGTCACCCCCGGCAGCGCCGCCGCCCGCGCGGGCCTGCGCGGCTGCGTGGCCGACCGCCAGGGCCAGCTCACCGGCCTGGGCGACGTGATTCTCAGCATCGGCGGCGTGCGGACGCCCGACAGCGGCACGGCGCTCGACCAGGTCAAGCGGCTCAAGGTGGGCGACCAGGTGGACGTCGAATACCTGCGCGGAGAGCAGCGGGCGCACGCCACCCTCACCCTGCGCGCGCAGCCGGTGGGCAAAACACCGCTGAATGCCGAGCCCTGCACCCGTCAGTAATTAATTCAGGCGGCAAAGGTAGAGAATCCCACAAGCCTTTTCCTATCCACGTTTGGCGCTGACCAGGCAAAATACAGAGATGTCGAGAGCTTTTGTCAAGGAAGACGGCGGCGAACGCTGGACCCCACCCGCAAAGGCCGCCGATTACCGGGTGGTCTTTGAGACGCTGGACGGCCCCGAGACGGTGTACGAGGCCGATGACCTGCTCGGCGCCCTGCGCTGGGCGGCGGCCCGCCCCGGCGCCGGCTTCGAGGTGCGCGGACGAGACGGGCGGCTGCTGGCCGTGAGCTGAGCAGAAATGAAGTAGGCGGGGAGCTGAACACACGGCTCCCCGCCTTTCTGTTCTCTGCTCTTGCCTTACCAGTCGCCCTCCACCGTGAAGCGCACCGCCCCCGCCAGCGCTTGCCCCGGCTCCAGCACCCGCAGGTCCACGCCGCCGACGCCCCGCGCCGCGAGATTGAAAGCGTCGGTGGCGTGGCTCGTCGGCTCCAGCGCGAGGCTGCCGTCGGGCGCGGCGAAGACGACGAGGTGCGAAAACACGTTGTCCGCGGTCAGGGTGAGGGCGCGCTCGCCCCAGTCCAGCCGGGCGACGCCGTCCCACGCGGTGTACGTAGCGTCGGGCGAACGCGTGCCCACCGCTGAAGGCTGGCGGAAGTCTTCCTCAGGGTTGACCGGGCGGGCTCCCCCCGTCGGCAGTTGCCGCTCGTCGGTGTCGTAGACGAGCGCGGCGTCAAAGTGCAGCGTCGGGTCCACCCCGTCCTGAATCCGCTGGAAATACGGGTGCAGGCCCATTCCAGCGGGCATCGGGCGGGCGTCGGCGTTCGTCAGGGTCACGCTGATATCGCAGTGCGGCCCATGCAGGTGGTACTCGACCTCGGCGCTGAGGTGCCAGGGCCAGTTGAAGTCAGGAAATTCGCGGCTGTCGAAGGTGCAGCGCAGGTGCGCGCCCGTGACCCGCGTGACCTGCCAGGGCCGGTTCCTCACGTCGCCGTGCTGGGTGAGGCCGTCTTTGGTGGTGACGCGCAGTTGAACGTCCTCGCTGCCGAAGGTCAAGCGGGCGTCCCGAATCCGGTTGGAAAACGGCAGCAGCGTAAAGCAAGCGCACTGGCTGCTCGTTTCGACCTGTTCCAGGTCCACTGGACGCAGCACCGGGCGACCAGATGCGGAACGCAGATTCAGGATGCTGGCGCCGAGGTCCGGCAAAATCTCAAGTTCGAGCGCCTCGCTGCGGATGGTTTCGGTGCGCCGGGTCACTTGTTCCCCCCGCTCTTTCCCCGGCTGCGGGTCATTTCATAGAGCAGGATGCCTGCCGCCACCGAGGCGTTGAGGCTCTGGACCTGTCCGCGCACCGGGATGCTGACCAGCACGTCGCATTTCTCGCGCACCAATCGGCGCATCCCTTCGCCCTCGGCCCCGATGACGAGCGCCGCCTTGCCGGAAAAGTCGGTGCGGGTCACGTCCTGCGCCGCCTCGCCCGCCGCGCCGTAGACCCACACGCCGTCGGCCTTGAGCTGGTCGATGAGCCGGGGCAGGTTCTTGGTCTGGGCGACGGGCAGGTACGCGGTGGCCCCGGCAGCGGTTTTGGCGACCACCGGGGACAGGGGAGCCGAGCGGCGCTCCTCCACGACCACGCCGTGCGCGCCGAGCACCTCCGCCGAGCGGATGATCGCGCCGAAGTTGCGCGGGTCGGTCACGCCGTCGAGCAGCACCATCAGCAGCGGTGCGCCACTCGCCTCGGCGCGGTCGAGGATGTCGTCCACCGTCGCCCATTGCAACTCCTCGACCTCGGCCACCACGCCCTGATGCTGTGTGGTTCCGACGAGCTGGTCGAGTTCGATGCGCGGCAGCCAGCGCACCCGCACCCCGGCGTCGCGGGCGAGGTCCTGCACCTGCCGGGCAAAGGCGTCCTCGACCCCGCGCGCCAGTACCACCTCGGCCACCCGTCCGGCGGGCAGGGCTTCGAGCACCGGGTTTCTTCCGTAAAGCAACATGTTCAGGAGTCTAAGCTGCCAGGGGGGGGAGCCGGCCGAGCCGTTACTCTGTGCTCGTGAACGGTCTTGCCCTCAACCTGATTCTGGCGCTGGTCTGGGCACTGTTTCTGGGCGAGGTCAGCCTGCGGAGCCTGAGCATCGGCTTCCTGCTGGGCTTCGCGGTCCTGACCCTCTTTCACCGGGCGCTGGGCAGCCGCGCCTATATCCGGGCGGTGGGCGGGGCGCTGCGGCTGACGGCGTACTTCGTGGCCGAACTGGTGCGGGCGAACTTCCAGATGGCGCGGCTCGCCCTGCGGCCCCACCCGCAACTTCACCAGATGATCGTCGCCGTGCCGTTGCGGCTGCGCGGCGAGGGGGCGCTGACCCTGCTCGCCGCGCTGACGGGGCTGCTGCCAGGCACCGTCACGCTGGGCTTCTCGCCGGACCAGGGCACCATGTATATCCACGCGGCGGGTCTGGAGCAGCGCAGCGCCGTGCGCCGCAGTGTGCAGGAAATCGAAACGCGGCTGTTGCAGATACTGGGGGAAAGGCAGGGCTCCAGCTGAAGACCCCCGCATGAGGAACGCGCGACGAGGTGCCCCGGAGCGGAGAGAAGCGGAAGAGAGTTTTCCAGCCCTAGCGCCCCTGCACCCACGTCACCAGGTCGCCCGCGCTTAGCGGCGGGGTCAGCGCGTAGCCCTGCGCGGCGTCGCAGCCCAGGTCACGCAGCATGTCGAGCTGGGCGTAGGTTTCGACCCCCACCGCCGTGACCGTCAGGCCCAGGCTGTGCGCGAGGCTGACCGTGCCCTGCACCAGCTTGAGCGATTTCTGGTCGCCCGGCAGCCGGGTGGTCAGGGTGGGGTGCAGCTTGACGCCGTAGAGCGGAAACTGGGTCAGCGCGGTCAGGCTGCTCGCGCCGTCGCCGAAGTCGTCCACGATCAGCCGGGCACCGCGCGCGCGCAGGGCGTCGAGCAGGCCCAGGGTTTCCTCGCTGTGGTCGAGCAGGCTGCTCGCACTCACCTCAATGTCCAGCGCACTCGGGCGGGTAATCAGCGGCAGCAGGCGCTCGATGGCCCCTTCGCGCCGCAGCTCTTCCAGGCTGAGGTTGACGCTGGTGCGCCAGTTGCGTTGCCCGGTGGCGTCGCGCAGCTGCGTGCGGCCCTGCACCGCCTCGCGCACCACCCATTCGCCGATGGAGGTGATGAGGTCGCTGCGCTGCGCGAGGGGCAGAAAGCGGGCGGGCGAGACGTTGCCGAGTTCGGGGTGTGTCCAGCGCAGCAGCGCCTCGGCGCCCAGCACCCGGCCGTCTTTGAGGCTGACCGCCGGCTGGTAGAGCAGCGAGAACTGCTCGTGTTGCAGGCCGCGGTCCAGCACCGCCCGCAACTGGTCTTCGAGCTCGAAGGTCTGGGCTTCCTCGGCGCGCATGTCCGGCTCGAACACCGTCAGTTGCCCGCGTCCCTGGCGCCGGGCGTGTTGCAGCGCCACCTCGGCGTCGGCCAGGGCTTGCTCGGGGGCCGCGGCCAGCAGCGGCGCGGCCCCCAGCGAAAAGGTCACCGGCACCAGCCGCTTGCCGGTCCGCAGCGGTTCGCGCAGCGCCGCCTGGAGCTTCTGGCCCCCCACGGCGGCCCCGAGCTGCGGCAGGTACACGGCGAAGGTGTCGTCGGCCAGCCGCGCCGCCTGCCCGCCTTCCAGCTCCGCGAGGTCGTTGAGCCGCGCCGCCACCTGAATAAGCAGCAGGTCGCCCGCCGTGCGGCTCAGCGCCGCGTTGAGGCCCCCGAAGCCGTCAATGTCGAGGCAGGCGACCATCCCGCCCGTTTGTGCTGCCGTGGCCTGACCCAGCGCCGCGCGCAGCCCGCTGCGGTTGAGCAGGCCGGTCAGCCCGTCGTGCGAGGCGTCGTGGCGCAGTTTGGCCTGGGCGCGGCGCAGGGTGGTCACGTCGCGCAGCGAGAGCAGCAGCTCGGGCGCGGCGCTCCGGCCCGGGGAAGCGGCCGAGGAACCGGTGGACTGACCGCTCCCCGGCAGGGCCGAGAGGCTGATTTCCAGATGCCGGGTCACGCCGCCGGGCAACACGGCCAGCACCTCGCCGTTGTGCGGCAGGGTCAGCGCCGAGAGGGGGGGCACCGTCAGCGGGTTGCCCTGCGGGGTGTGCAGCTTGATGCCGAGTTGCTGGTGCAGGCGCGGCAGCGGCAGCCCGGTCAGGGCGATGTTGTGGGGGTCGAAGCCCAGCAGCCGCGCCGCCGGCTCACTGATGAGCTGCACCCGGCCCTGCGGGTCGAGCAGTATGGTGGCCGCGCCGCTCAGGTGCAGCAGCCGCGCCGCGCCGTTGTCCTCGCTCACCGCGGCGGGTCGGACACCCTCGGCGAGCAGCAGCCCCGGCACGGTGTCGCTGCGGCGCACCAGCAGCGGCAGTTGCCCGCCGCGCGCCAGTGCAATCTCGCTCGGCACCGGGCTGGGCCGCCCCGCCTCTGCGCTCTGAATGAGGTCCTGAAGCAGCCGCGCGCCCGCCGGAGCCCAGCAGGGCCACTCGTGCAGGGGCCGCTGGGGGTGAGCCTGGGCTTCGGCGAGGTCTTCGGGTTCCCCCAGCAGTTGACGCATCCCCCGGCTCGCCCCCTGCACCGCGCCGCCCGGTCCCAGCAGCGCCAGCGGCAAGTCGGTGCCGAGCAGCGCGGCGAACTGGGTCGTCTGGGTGTGCTCGGTGCTCACGTCCTGCACGGTCCACAGCACGCCCGCCGCCGCGCCGCCGAAGTAAGGCCGCGCCGACCCACGCAGCCAGCGCTCCCCGCTGTGCCCCGGCAGGGACGGCACCCGCTCGTCGCCGAGTTGCACGGCCCGCCCAGCCGCCGCGCTGTCGAGCTGCTGCGCGAGCGCCGCGTGGTCGGGAAAAACCTCGTGGACGGTGCGGCCCAGCACATCCGCCCCGGTCAGCCCGAACAGTTCCAGAAAGGTGCGGCTGACCTGTCGGAACTCCAGCTCGGCGCTCAGCCACGCCGTTGCGGCGGGAAGCTGGGTGATCAGCATGTCGGCCTCGCGGCTCGCCCCCTCGGCACTCGCCGCCGAGAGCAGCAGCGTGAGCACCTGCACCGCGCCGTCGGGCACCGGCGCCCCGTCGGACCACAGCAGTCCCAGCAGCGCTCCGTCGCGCGTGATCCAGGCGAGGTCGCCGTGTTCGAGCCAGTCGTCGGGCGGCACCAGTTGCGCTTCCTCGGTGGGCGCGCCCTCGGCCTGAATGTTCAAAATCCGTTGCCCGATGGCGGCCAGCAGGGTGGCCTGCGGAGCGTGCAGCCGGATCAGGTCACGCAGGGCAATGGGCAACGCGGCATGGGCATCGGTCGGGGCAGCGGGCATGGGGTTCAACCTCGGAAAAAGCGGGAAGCGGGAGAAACGGGCGCGTCGGGGCGCCTTGAAATGAACTGCTGTTCTGAGCTTGCCACGTCGCCTCTTACGGTCTTCATGCAAGCCAAAGAAATAGGAGGAAACTTGCTGCTGGGCGCTTAGAGCATTGGATACAAAAAGACCCCCTCACCCCTTGCTTCGCAAGGCCCTCTCCCACCAGGGTAGAGGGTCAAAAATCCAAAGCATTCTTATGTCGAACACTCTAGGGACACCCATCGATCAACAGCAAAAGGCCCACCGCCGCGTGTGCAGGGTGGGCCTTCTGAGGAGAGGAGAATTCAGGCGCTCGGTTTGTCCGACTTGTCCTCGGCGGCGCTCTCTTCTTCGGTGCTGAGCGAAGCCTCTTCGATGGAGATACTCGCCATCAAGACCACCTTGTCACCGTCCTGCTCGACCTCGACCTTGGAGTTGCCCGAGGGGAAGTACTTTTGGACGACTTCCAGCAGGTCGTTGCGCAGGGCCTCGACCTTGCCGGGCGCGATCTTGGCGCGGTCATAGGCGAGCACCAGTTCGAGGCGGTCCTTGAGCGTTTCCTTGGAGCGGCGTCCCTTGAACCAACCGAACATCAGCTCCCACCCCCGAACAGGCGGCGAATGGCGGCCCAGATGCCTTTTTCTTCCTCGGTCAGCTTGGGAAAGGGCACGTCCTGACCCTGAATGCGCTGCGCGGTCGCCATGAAGGCGTCGCCCGCCTTGGTCTTGCCGAGCACCGCCGGCTCACCGACGTTGGTCGAGACGATGATGCCCTCGTCCTCAGGCACGATTCCGATGGGCTTGACGCCCAGGATGTCCACCATGTCGTCGATGGAGAGCATGTTGCCGCTCGCCACCATCTTGGGACGCAGGCGGTTGACGACCAGCCGAATCTCGGTGATCTGCTGCGCTTCGAGCAGGCCGATGATGCGGTCGGCGTCGCGCACCGACGACACTTCGGGGTTCACGACCACCAGGGCGCCCTCGGCGGGGGCGGCGGCGGTGCGGAAGCCCGACTCGATCCCGGCGGGCGAGTCGATCAGCACGCGGTCGAAGCCCTCTTCTTCCAGCAGGCCCTTGACGACTTCCTTGAAGACCTCGGGGTCCAGGGCGTCCTTGTCGCGGGTCTGCGAGGCGGGCAGCAGGTGCAGGTTCTCCACGCGCTTGTCGCGGATCAGTGCCTGATTCATGCGGCACTTGCCTTCCAGCACGTCCACCAAATCGAACACCACGCGGGACTCTAAGCCCATCACCACGTCCAGGTTCCGCAAACCCACGTCCACGTCGATCACAACGACTTTTTCACCCAGTCGGGCCAGGGCCGCGCCGATGTTGGCGGTGGTCGTGGTCTTGCCCACGCCCCCCTTGCCCGACGTGACGACAATCACTTTGGCATCCATGCTTGGCGCAGCATAGCAAGGCAACGTGAAAATGTAAGCCTGTGGGGGTGGAGGCCGGGGGAGGGGTTGCGGCAGGTGTGCCGGGTGGGGACAGCGGCCCCGAATGCAGGCGCCGGGAAGCCGGTAGACTGCCGGGCAGCATGACCCGACTTTCCGGAAACAATCAGAACCGCAGCGTCCTGATCATCGGCACCCTGGTCGCCGCCGCGCTGATCGCCCTCGCCCTGTTCGCCGTGCGCGGCAAGAGCACGACCACGACTGGCGAGGCGCAGACCTTCACCTACGCCAACTTGCCCTACGCGGGGCAGGCGAACGCGCCGGTCAACGTACTGGTCGTCGAGGACTTCAAGTGCCCCAACTGCAAGTCCTTCGAGGAAACGGTGGCGCCCGAACTGCGGACCAAATACGTGGGGACCGGCAAGGTCAAGATGTACTCGCTGGTCTACCCCTTCCTCGCCGACCGTCTACCCGAAGACGACAGCAAGTACGCCGCCCAGGCCGCCCGCTGCGTCTACGCTCAGGGCAAGAACGACGCTTTCAATACCTACAAGGAAATCCTGTTCCGCGCCCAGGGCCCGGAAACCGAAGTCTGGGCCACCAAGTCGCGCCTGAAGGAGCTGGCGACCAGCCTCGATATCGACCAGGCCAAGTTCGCCACTTGCCTCGACAACGACGAAACCGCCGCGCAGGTCGAGACCGACAAGCAAGAAGCCCTCAAGGCGGGCGTGGGCGGCACCCCCACCGTCTTCGTCAACGGCAAGCTGGTGAATGTCCAGAGCGATTACGTCAAGGACATCTCGGCGGCCATCGACGAAGCCCTCAAGCCGTGAGCAGCGGGGCATGAACCGCGACACCCGGTTGTACCTGGCCTGGTTGGTGGCCCTCGCCGCCACCCTTGGCAGCCTGTATTTCAGTGAGATTCGGCACTTCAACCCCTGCCCGCTGTGCTGGGCGCAGCGCATCTTCATGTACCCGCTGGCCGTCATTCTGGGCATCGCGGCGTTTGTGGGCGACCACGGCGTGCGGCGCTACGTGCTGCCGCTGGCGGCGCTGGGGCTGGGCTTCGCCATCTTCCAGAACCTCGAAACCTGGGGTTTCGTTCAGTCCATCAAGGCGTGCACCGTCAACGCTGCCGCTGCCTGCAACACCCCCTGGCCGGTGTGGGGAACCAGCCAGGACACGCTGAACCGTGCGCTCACCATCCCGGTGCTGAGCATGATCGCCTTTGCGCTGATTCTGGCGCTGCTGAGCTGGCCCCGGCAGCGCGTGACCGTGCCCGAAAGCGCGGCAGTCCAGGGCTAAAGTTGCAACTCGAGCGCCCGGCCCCCTATACTTCTCCGGCCCGGTTTGCCTGCCAGCGTGCAGCGCGAGCCTGAAAAGGAGTACGAACGTTTCTGCCCGTGAAGAGCGGGACCTCGGAGACGGTCCGCTGCCCGAAGGAGACCCCCCATGCAGACCCACATCAAGATCAACCGCGGCGAGCTGCTGCGCGGCATCGAGCAGGACCACACCCGCCAGCTTCCCGACTTCCGCCCCGGCGACACCGTGCGCGTGGACACCAAGGTGCGCGAAGGCAACCGCACCCGCAGCCAGGCCTTTGAAGGCGTCGTCATCGCCATCAACGGCTCGGGCAGCCGCAAGAGCTTTACCGTGCGCAAGATTTCGTTCGGTGAAGGTGTGGAGCGCGTGTTCCCCTTCGCTAGCCCCCTGGTCAATCAGGTGACCATCGTGGAACGCGGCAAGGTCCGCCGCGCCAAGCTGTACTACCTGCGCGAACTGCGCGGCAAGGCCGCCCGCATCAAGAGCGACCGCAGCCGCGTGATGAAAGACGCCGCCCGCGCCCAGCAGGACAAGGCGAACGCCAGCGCCAGCCAGGCCGCTGCGGCTCAGGCCGACGTGACCGTCATCAGCGCCGCTCCCGAAGTGGCCCCCGAAACCCAGGGCGAATAAGTCCAGGGCTCCCAAGCCCGCCTGCCTCCGCGTGAGGTGGGCGGGTTTCTTTTGGCTGTGGGGTGGGCGTTTACAGGTAAGCCAGTTCCCAGTCCTTGGCCCCGTGCGCCAGCCCTGCTCGCAGCAGCGCGAGGCCACTCGGCGCCGGGTCGCGCCAGTGGGGGAGGCCACTCAACTCAGCCTCGAACTCGGCCAGCGGGCGGCGGGCGACGGGCTGCACGGTGTCTGTTACGGTGCCTGCGCTGACCTCATAGACCGCGCTATACACGTTGCCTTTGCGGGCGTCGAGGCTCACCGCCTGCGGGCCGTCGCCGCGCACCAGACTTTCCAGGGTGGACACGCCGCGCACTTCGGCGCCCCACACGCGGGCGAGCCCCAGCGCGTAACTCGCGCCGACGCGCACGCCGGTATAGGAGCCGGGGCCGGTGCCGATAACGATGGTCTGGGCCTGAAACGGCAGCCCCGCCGCCCCGAACAGGGCACGGGTCTCGTCGGCCAGCCGCTCGGCGCTCGCCCGCCCGACCTCCTGCACCCGCTCCAGCTCGCCGCCGGGCCAGCTCACGGCCAGCGTGAGGAAGGGGGTGGCGGTGTCCAGGGCGAGGGTCACAGAAAGAGGGGTGACAGGGGCGGCGGAGACGGTCATCGGGCGTATTAAAGCAGAGGCCGGGGCAGGCGCCCGTGTGCCCTGCCCGCTCTCATCTCTTTGTCACCCCGGCAGGGACGTTTGACCGCCCCTTTTTCGCCCCCTGGAAGAAGGGCAGGTGTTATCCTCTGCTCACTATGTCGAACATTGCCAAAGGGCTTGAAGGTGTTCTCTTTACCGAGAGCAAGCTGACGTTTATCAACGGCTCGGAGGGCATTCTGACCCACCTGGGCATTCCGATTCAGGAATGGGCCGAAAAGAGCACCTTCGAGGAACTCAGCCTCGCGCTGCTCGACGCCAAACTGCCCACCGCCGAGGAACTCGCCAAGTTCGACGCCGAACTCAAGGCCAACCGCGCCATCCCCGATCAGCTCGTGGGCATCATCCGCGACATGCCCAAGGGCGTACACCCCATGCAGGCGCTGCGCACGGCGGTCAGCTACCTGGGCCTGCTCGACCCTCAGGCCGAGGACATCACCCCTGAGGCCCGGCGCGCCATCAGCACCCGCATGATCGCGCAGTTCTCGACCATCATCGCGGCGATCAACCGCGCCCAAGAAGGCCAGGACATCGTGGCCCCCCGCGCCGACCTGACCCACGCGGGCAACTTCCTGTACATGCTGACCGGCAACGAGCCCACCCCCGAGCAGGCCCGTCTGTTCGACATCGCGCTCGTGCTGCACGCCGACCACGGCATGAACGCCTCGACCTTCACGGCGATTGCGACCAGCTCGACCCTCAGCGACATGTACTCCTGCATGGTGAGCGCCATCGGCGCGCTCAAAGGCCCGCTGCACGGCGGCGCCAACGAAGCCGTGATGACCATGCTCGACGAAATCGGCACCGTGGACAAGGCCGAGGCGTACATCACGGGGAAGCTCGACAACAAAGAGAAGATCATGGGCGTGGGCCACCGCGTCTACAAGTACTTCGACCCCCGCTCGCGCGTGCTGCGCGACTACGCCGAGCACGTCGCCAACAAAGAAGGCAAGAGCAACTACTACCAGATCCTCGAAGCCATCGAGAAGATCATCGTGGACCGCATGGGCGCCAAGGGCATCTACCCCAACGTGGACTTCTACTCCGGCACCGTGTACAGCGACCTGGGCATCAAGAAGGAATACTTCACCCCCATCTTTGCCCTGGCCCGCATCAGCGGCTGGTGCGCCAGCGTCATCGAGTACAGCCAGGACAACCGCCTGCTGCGCCCCGACGCCGAGTACACCGGCGCCCGCGACCAGCACTACGTGGACATCAAAGACCGCCAGTAAGCGGAGAAGGTAAGAAAGGGGGCCGGAGCATGGCGCTGCGGCCCTTTTTCTTTGCTGCCTGTTTCGCTTTACAGCAGCCTGCCACCATCATGCGCTTCGGGCGTCTGCACCGGCACCCCCCGCGCATTCAGGGCCTCGCGCAGCATGGGGATGTTTTTGAGGGCATGCCCGCCAGTCGTGTTCTGGAAAAACACGTACAGCTCGGAGAGGTCACCGGCGACTGCCGCAATTTTCTCGGCCCATTCGTCCATCTCGGCGCGGTTGTAGAGGTAATCGTGGCGCTCGCCCGCGCTCTGGCCTTCCCACCAGGTTTCGCGGTTGCGCCCGTGCAGGCGCAGGTAGCCCACGTCGCCGGTTACGTGGACCTGGGGTTCGGGCATCCCACCCACTGGCGGGTAATCCGGGCTGACCCAGATGATGCCGAATTCGCCCATGCCCTCGCGGACTTCGGGTTTGTCCCAGCTCGCGTGCCGCAGTTCCACCGCGAGTTCGTGCCCAGCAAAGCGCTCGGTGAGCAGCGCCAGATACTTGCGGTTGGCGGCGGTGCGGTGAAACGAGTAGGGAAACTGCGCCAGATACGGCCCCATCATGCCGGCCTCGCGCAGTGGCTCGGGGCTCTGGAGCATTCGGTCAAAGTCGGTGTCGGTGGGAGCGCGTACGTGGGTAAAGACCTTGTTCAACTTGACGGCGAAGCGCACCCACCCGCCCGATTTGCGGACCATGCCTTCAAAGGCCTTGAGGCCGGGAATCGCGTAGAACGATGAATTGAGCTCCACCGCGTCGAAGTGGTGGGCGTAGGTCTCCAGAAAGGCGTCTTTCTTGACGCCCTCGTAAATCAGGCCCGGAGCCGTCCAGTCCTCGTCGGTGTAGCCGCCGCAGCCGATGTAGACGCGCATGGGGGAGAGGGTAGCGGGTGGGCGTGGGAAACATATTTACAGTCCGCAGAGAATCCCAGCAGAGACTTGGAACTCCAGTAGCTCTCAGGGCAAGCAGGAGCAGGCGCTGCCTTGCATTGGCGTCCTGCGCCCTGAACGTCTGACCCCGTTCCGCCTACAATCTCCCCCGTGACCCGCTCCGTCAGCCACCCGCCCTACGCCGACCCCTTCGCCCACCCGCCCGAGACTTCGCCACAGGAACTGACCGCCCAGCTGACTCCCGGCGCCCGTTTTCAGGACGTGCGCTTTGAGAACTACCGGCCCAACCCGGAGTTTCCCAGTCAGGCGCAGGCGCGCGACCAGCTTGCGGAATTCGTGCGGCAGGCGGGGCAAAAGGCGAGCGGCGGGGGCTTCTGGCCCTTCAAGCGGAGGGCCCCGGAAGGGCGCGGATTTTACCTCGACGGCGGCTTCGGCGTGGGCAAAACGCACCTGCTGGCGAGCGCTTACCACGCGGCCAAAGGGCAGTCTGGGGGCAGCGGGGGCGACGTGGCCTTCATGTCGTTTCAGGACCTGATGTACCTGATCGGGGCGCTGGGGATGCCGCAGGCCATCGAGACTTTCCGGAACTACAAGCTGCTGCTGATCGACGAATTTGAACTCGACGACCCCGGCAACACCCACATGGCGAACACCTTTCTGGGCGGGCTGATGCCGAGCGGCGTGAGCGTGGTGGCGACCTCCAACACCGAGCCGGGGGCGCTAGGCGCAGGGCGCTTCAATGCCGAGGATTTTCAGCGGCAGATTCAGGGGATCGCCGACCGCTTCGGGCCGCACCGGATAGACGGCCCCGACTACCGCCAGCGCGGCACCGAGCCCGCCCAGCCGCTCAGCGAGGCCGAGTTCGCGGCGTGGCTCGCGCGCCAGAACCCGCAGACGACGGCGCTGATGACGCACGCCGAACTCAACCGCGCTCTGCTGAGCGTGCACCCGAGCCGCTTTGCCCGCGTGCTGGAGCAGGTGAGCGGCGTAGCGGTGACGAACCTGGAACCGATGCCCGAGCAGGGAGAAGCGCTGCGCTTCGTGCATTTCGTGGACAAGGTGTACGACCTCGGGCTGAGCGCCGCGTTTACCGGGGTGCCGCTCAATGCCCTGTTTGACGACATCTACCGCAACGGCGGCTACGCCAAGAAGTACAGCCGGGCGCTGAGCCGCCTCTCGGAAATGCTGCGGGAGGCGCGGGGGTAAGGGACTTTTCCCTGTCCTCCAGCTCCCATGTTTCGCCGTGACCCCCTCATGGCCCAGTGGCGCGCCGTGGCCCGCTTGCTTGAACTGGACGACGCGCAGGCCCGCGCCCTGCTGGGGCTGGTGCGGCAAACCTTGCGGCGCGGCGGGGTGCTCGGCGTAGCGCGGGGAGACGAGCGGCAGCTGCTGACCTTCGGCGGCGTACCGGAAAATGGCGTCTTTGAGCTGGCGAGCGTGACCAAGCCCTTCACGGCGGCCCTCGCCTCGGCGCTGGTGCGCGATGGGCGGCTGGACTGGAACGCGCCCCTCGCCGCGCTCGGCGGGCCGCTGCGCCGCTTGCCCCGCGCGCTGACGCCTTATGCGCTGGCGACCCACACGGCGGGGCTGCCTCCGCAACCGGCGCGGGCTGCGCTGACCACCTTCACCCGGTTTGCCGACCCCTACGGCGGCATGTCACCGGCGGACGTGCTGGCGAGTGCCCGCCGCTGGGCCAATCCGGGGCAGGCGGGGCGCTTCGGATACTCCAACCTCGGCGCGGGGGTGCTGGCGCTGGGGCTGGCGCACGCGGCGGGGGAGGAGACGTCGGCAGCGGGCTATAAGCGGGCGCTGCGTCGCCTGGTCACCTTTCCACTCGGACTGCCGGGCGTGGGTCTGACCCCGGCGCGGGATGTCGTGCCGCCTTACGGTCTGCTCGGCGGGCAGGCGGTGACGGGCTTTGCCGAACTCGCGGGCGCGGGGGGCCTGTTCGGGAGCGCGGCGGAGTTGCTGCACTTCGGCGAGGCGCACCTGAGCGGGGCAGCAGGGCAGCACTGGCGGCAGGCGCAGGCTTTTCCCGGCTTGCCGCCGCTCTACGCCGGGGCCGCGCCGGGGTGGTTTCAATCGGGGAGCACCGTCTGGCACGACGGCATTGCCCGTGGCACCCGCACGGCGCTCGGGTTCTCGCCGCGATCCGGCGCGGTGGTCACGCTGCTGGTGCGCGGAGCGGTGCCGCTGGTGGGGGTGCGGGCGGGGGTACCGCTTTTGCTGCTCGGGTTGCTGGGCGGGACAGACCGTTAGAGCATTTGACAGAATGATCAGATCTGTCTTTGACCCTCTACCAAGGGGAGAATTGTCAAGCTGCGAAGTAGAGGGCCTTGCGGAGCAAGGGGTGAGGGGTCTTCACGTCCAGTCCTGCGCGAACTGCTCCCAACTCGCCGTGTCGCGGGGGCACCCGCCCGTCTCCGTCCATTCCCAGTAGGGGGTGTAGAGGCTGCGGGCGGTGACCAGCTCATCGCGGAAAATCCGGGCGCTGAGGCCGGTGTCCAGCAAACCGCTCGTTTCAAAGCGCTGAAGCACGCCGCTGCGGTCGTAGGGCACCCGGCGCAGCTCGGTCTGCCAGCCCTGCGGCGTGGCGGTGAGCAGCAGGTACTGCGCGCGGGGGTCGCCGTCCGCCGGAGAACCGACGGCCCCGGTGTTCAGCACCCTCACGCCGCCCACCAGCGCGTCGGCCTGGCGGTGGATGTGCGAGCCCACCAGCACGCCCGCGCCCGACTCGTCGGCAATGCGGCGAACCAGCGCGGGGTCGGTGCGTTCGCTCAGGCCCCGGCGGTAGTCGTCGGGGGTGCCGTGCGCGAGCAGCACGTCGGGCAGGCCGGGCACGCTCAGCCGCGCGGTCAGCGGCCAGTCTCCCGGTACGTCGAGCAGCCCTGCCGCGTGCAGTTGCTCGGTGCTCCAGGCCGTCGCGCCCCAGAAGGGGTCGTCGTACCAGTCCTGCGGCAATTTATCGCTGCGCGTGTGCCACAGCCGCAGCAGGTCGTCGTGGTTACCGAGGACAAACGACGTGTCGTCGCGGGCGAGCAGTTCTTCCATCACCTGCACCGAATCCGGCCCCCGGTTCACCACGTCGCCGTTGACGATCAGCCGCTCGGCGCCCTGCTCCGCCGCGTCTTTCAGCACGGCCCGCAGGGCGTCGGCGTTTCCGTGGATGTCGGCCAGCACAGCAATTCTCACGGGGGCATTGTAGGCGCCGCTTCCGAAGAAAATACTGAAGAAAACCCCATACCCGTTCAGGCCCCGTTTGTGGTTACAGTAGGGCCATGAAGCCACTGAAGATGCTGACTGTTGTTCTGCTGGGTGCTGGAACGTTCGCTTCGGCGGCTTCGGTGACTTCGGCGGTCAAGACCGAGATCAACCAGCTCGCCCGCCAATACACGGGCCGCCCGTGCCTGAGCAATGGCGAATACGGCCTGGACACCGAGCCTTTTGGCCGCAAGGTGTCGCCGAGCGAGCTGAGGACGGCGCGGGATATCCTGTACCGTCAGTTGCTGGAAGGTTTCGACCAGAGTGCACGCAAAAACCACTTCACCTACGAGGTGCGCTACAACCAGAACCGCGTCTGGGTCTGGGCCAAAGCCCCCAACTCCTCCCGGCAATATTTCACCTTCGCGACCCTCAGCCCGACCGGCATTCGAATGGTGAGCTGCCTACAGTAAGCGGACAAGAAGAAACAGGCCCCTTCCCGCTGTGGAGGGGGCCTTTTGCTGTTTAAGGTTGCCGAATCCAGTACCGCCGAATGGGCTGGTCATGATACTGGGGCACCTCAAATTCCCCTTCCAGTTCGCCGCCGTTCGCCTCAATGACGCCGCGTGAGCCGAAGTTGTCCACATCGCAGGTGACCAGCACCGGGTCTATCCCCAGTTCGCGCGCCCGCTCCAGCGCCAGCCGCAGAATCAGGGTGCCGTAGCCTTTGCGCCGCGCGCTGGGGCGGATTTCGTAGCCGATGTGGCCGCCGAACTCACGCAGGCGGTCGTTGAGGCTGTAACGGATAGAGACGCGTCCCAGGTACTCGCTCCCCTCCACCAGCCAGCGGTATTCGGAGTGGACAAAGCCCTCCGGCAACTCGTTGCCCGGTTCGTAACGGGTCAGGTCGCGCAGGACTTTGCCGAAGTCGGCGCTGATGTCGTCGAGCTTCCAGACCAGCGTCTCGCCCAGGCCACTGCCGGTTTCCTGTGCCTCGCGCACGGCGGCGAGGAAGCTGTCTTTGTACTGTTCGGAGGGGCGTACGAGGTGTGGCATGGGTCAGGGTAAAGGTTGGCGGTGGCCTGGGCATCGGCCACCCGGCCTACCCTCACCCACCAACCGGGTTGGTCAATCTGTCCCGAAATGGCGTCCGCAGCCCCATAAAGCGGCGGGTGGGGGGCGTACAATCCGGGATGTGAAAGAAGCGGCCTTCGACGTGCTTGACCTCGGCCTGCTGCCCTACCCGCAGGCGTGGGCGCGGCAGAAGCAGGAACTGGCCCGCGTGGCGGTGGGCGGGCGGCCCACGCTGCTGCTGGTGGAGCACCCCGCCGTGCTGACGCTGGGGCGCAAGGCGCAGGAGGGCGAGAACATCGTGGTCACGCGCGAGTATCTGGCTGCGCAGGGCATCGACGTGTTCGCGGTGGAGCGCGGCGGCGACGTGACCTACCACGGCCCCGGCCAGCTCGTCGCCTACGCCATTTTTCCAGTCGGGCGCCGGGTGCGCGACTTCCTGCGGCTGCTGGAAAACGCAGTGGTGACGGCGCTGGGCACCCTCGGCCTGCCCGATGCCCGGCCCAATCCCGGCTACGCGGGCGTGTACGTGGACCCGCGCGAGATCAACGGCAAGACCTACGACCAGAAAATCTGCTCCATCGGCGTGGCCATCAAGCAGAATGTCGCCCTGCACGGCATCGGCCTGAACGTCTGCACCAATCTGGACCACTTCGACCTGATCGTGCCCTGCGGCCTGACGGATACCCAGATGACCAGCGTGCAGCGTGAGTACGACCTGCGCGGTCTGGGCAGCGTCAGCATGGAGCAGGCGAAAAAGGCGCTGACCGACGCTTTCGCCTTGACCTTTGCCGACTATGATTGGAGCCTTCCGGGGGTGGCCGCCGGGCAGGAGGCGCTCTCTGTGGCCTCTCCCTAGCCTCCTTGACCAGCCGTCACCCTCCAGCGACCCTTTCCAACCGAGGAAACCGAAATGACCCAGCAAGACCCGTCCACCAAGGAACCTAAATTCATCAAAAACGGCATCTACCGCAAGGACAGCGTGCCGGTGCGCGAGAAGAAACCTGAGTGGCTGAAAGTCACCATCCCCACCGGGCAGGTGTTTACCGAAGTCCGCAAAATCGTGAAGGAGCACCGCCTGCATACGGTGTGCGAGGAAGCGATGTGCCCCAACATCGGCGAGTGCTGGTCGCGTGGGACGGCGACGTTCATGCTGATGGGCCACATCTGCACCCGCGCCTGCCGCTTTTGCGCGGTGGACACTGGCAACCCGATGGGCAAACTGGACCTCGACGAGCCGCGCAGCGTGGCCGACTCGGTGCGGCTGATGGACCTGAAGTACGTGGTGCTGACCTCGGTGGACCGCGATGACCTGCCCGACGGCGGCGCCTACCACTTCGCCAAGACGGTGAAGGCCATCAAAGAGGTCAATCCGCAGACCCGCGTGGAAGCGCTGACGCCCGACTTCGGCGGCAACACGGCCTGCGTGGACCTCGTGCTGGACAGCGGCGTGGATACCTACGCCCAGAACCTCGAAACCGTGCGGCGCCTGACCCACCCGGTGCGCGACATTCGCGCGAGCTACGACCGCACCCTGAGCGTGCTGGCCCACGCCAAGCAGGCCCGCCCCGACGTGATTACCAAGACGAGCCTCATGCTGGGCCTGGGCGAAACCCGCGAGGAAATCCGCGAGGCGATGGCTGATTGCCGCGCCGCCGGGGTGGACGTGCTCACCTTCGGGCAGTACCTGCGCCCCACCATGCACCATCTACCGGTGGAACGCTACATTTCGCCCGCCGAGTTCGACGAAATCCGCGAAGAAGGCATGCAACTTGGTTTCCTGGAAGTCGTCTCCGGTCCGCTGGTGCGCTCGTCGTACAAGGCTGAGCAGATCGTGATGGACCGGCCCGGCAACCTGCCCGAGCACCTGAGCCACTTAGACGGCGGCAGCGAATTGACCTTGATTTGAGATTGAGTGGGAAAGGGGCCGGGGCCATGCGCTCTGGCCTTTATTCTTTGGGTCGGTACTTGGCTTCGAGGCTCCACCAAAAGTCGGACGCGCCGCTGCCTACCGTCCGTTACCCTGACCTCAATGTCAAAATTCCGGCGAATACTGCTGCCCCTGGCGCTGCTGGCTGCCCTGGCTCCAGCACAGGCGGCCCCACCTACGAGCTATCAGGGGCCGGTGTACGGCGCTGGCGTGCCGAACGTCAAGGTGGTTCGCCCTCTCTGGACGTTGACGGTAGATAAGGCCGAGTACGGCGACAGGGCCGTGCTGCTCGCTGAAAACCGCGTGCTGGTGAAGGTGGGCGGGGCGTTGCAAGCCCGCGACGTGGCGACGGGCCGCGTGCGGTGGACGCTGCGGCAGCCGGGAAACCTGGGACTGGCCGACAAAAACGCTGTCTTTCTCACGTCCGGCCCCACCCTGAGCGCTTACCGGCTCAGCGACGGGCGGCGCCTGTGGACCCGCGACCTGGGCGGCGCGGTGCGCGATGTGGGCGAGTCGGGCGGCGTGCTGTACGCGACGACGGAACACGGCGGCATAGCCCTGAGCGCCGCGACGGGTCAGACACGCTGGGCCTTTAAAGAGCACGAAATGACGGGCTTCCGGACGGTTCTGGGCGACACAGGGTCAGGGGGCGTGGTGTTCTGGGACGCTTACCAGGGCGAGCCGCATTTTCCGGCCACCTACGCCTTTGACGCGGCGACGGGCAAACAGCTCTACCGCCTCGGCGGCACGACGGGGCCGCTGGGCGTGCGCGGCAAGGCGGTCCTGATGGCCGACACGAGCTTTATAGGAAGCGATGACAATGCCACCCTGACCTGGGTAAACCTGCGTTCCGGCGTCACTGAACAGGTCTTGAAGCTGGCCGCCGATTTCCGCTGCCCTGGCAGAGGCACCCTGGAGCGCCGCACGTCCGAAACCTTCTCTGCCCCGCCGCACATTTATGTCAATGACCAGTGCGGCACGCGGCTGCGGCAGTTCTGGGCGAATGACCCGGCGCTGGCTGGAAAAACGCCGTCCACGCCGCTGCCACCCGCCCGCACCTTCGCCGTGCCGGACGACGGTCGCTTTCGCCTGGGGCCAGTGGGGGAACTGTTGGTGTTTGAAAGCCGCATGGGAGAAGTGCGCTTGATTCCAACCACGGGCCGCGCGCCTATCAACTACAACGGGGTGGATATGCCGACCGGGACGGGCCTTGTCCTGCCGGGAGCGGGGCCGGTGTCGCGGTTGGACGCCCTGGGGAGCGTGCTGTATGTCGGGCGAGTGAATGGTGAGTTTCTCGCCTACGACGCCGCGAAGAAAAAGCCCCTCTACGCGGCGCAGCTTCCCTGGCGCGGCTTCGGGCCGACCTTCCGCAGTGGCAAGTACGCGGTGCTGACCACTCCCGGCGCACTGGCTGTGGTGCGCGAGCCCTGAAAACGCTGGTGGTCGGCGGCACCGGCATGCTGCTGGGACTGGTGCGCGAGCTCCTCGCGGCGGACGACGAGGTGTGGACGCTGGCCCGCCACGCCCCGGCGCTTACGCACCCGCGCCTGCATCCCCTGCTGGCGGACTACCGCGACGCAGCGGCCTTGCGCGCGGCCCTGGCCTCCGCCACGCCGTTTGACCGGGCGGTGGTCTGGATTCACTCTGCGGCGCCGGACGCGCCCTTCGTGGTGGCCGAAGCGGTGCGCGGGCCGTTTTTTCACGTCCTGGGCAGCGCGGTGGCCGACCCGTCCAGACCCGACGACGGGCGGCGGGCCCGTTTCGCCGCGCTGGGCACCGATGCGCGTGACGTAGTGCTGGGCTTCGTGCGGGAAGGCGAACACTCACGCTGGCTGACGAACGCGGAAATCTCGGCGGGGGTCTGGGAGGCTGTGCAGGGTAATGTTCAGCGGGCAGTGGTGGGAACGGTGACGCCGTGGGCCGCGCGGCCCGGCTGACCGGCGTGTTCCTGCTAGCCTCGCCTCATGCTTGACCCCCGTTCTGTTCCTTTTGCCGCTCAGATTCACCCCCAGGCCCGCCCGGCGCGGCGGCTGACCTGGGACTCGCGCGAGGCGGGGCCGGACACGGCGTTCGTCGCGCTGCCCGGCGAGAAGATGCACGGCAACAGGTTCGTCGAGCGGGCGCTCGCGGCGGGGGCGCCCTTCGTCCTGACCGACCTCGACGTGCCCCGCGCCGTGCGGGTAGATGATGCGCGGGGGGCCCTGTTCGCCTGGGCGCGGAGTGAACGGGCGAAAAACCCGCTGGTGGTGGGCATCACCGGCAGCGCGGGCAAGACGACCGCCAAGAGTTACGCGGCGGCGGCCCTGGACGCCCACTTCATGCCGGTGTTCAACACCATGCCCGCCATCGCCTGTTTTCTGGTGCAGTACGGCGCGAGCCAAAAGCCGCTGGTGGTGGAGATGGGCATCGACCACATCGGCGAAATGGCCGAGCTGATGGACCTCGTGCGGCCCGATGTGGGCGTCGTGACGACCATAGGCCCGGCGCATCTGGAGCAGTTCGGCATGGTGGAGACCATCGCCCACGAAAAGGGTCAGATTCTGACGGCGCGGCGGGCATTGGTCGGCTCGCAGGCCGCCGCCTTTTTCCCCAAGGCCCAGTTTCCCCACGTGGACAGCTACGGCTTCGGCGACGTGACGTTCCGGGGCGAGGGGCTGGAACTCTCGCCGCAGGCCGCTCGCTTCCGCTTCGGCGGCATGGGCGTGATTTTGCCGCTCGCCTCGCGGGTGCAGGCCGAGGCCGCCGTGCTGGGGATGGTCCTCGCCCGCGAAGCTGGCATCGCGCTGGCCGACGCCGCCGTGCGGATGAGCGCGGTGGAAGTGCCCGGCGGGCGCTACCGACTGCATCCGGGCCGGTTTACCGTCATTGACGACGCCTACAACGCGTCCCCGGTGGCGGTGCGCGCCGCGCTCGACGCCCTGCACGCGCTGAAGCCGGAGGGCGAGGTAGGCCGCCGCATCAGCGTGCTGGGCCGGATGCTGGAACTCGGCCCCACTGAGCGTGAGCTGCACGCCGAAGTCGGCAGCTATGCCCGCGAGCAGGCCGACCTGACCTACGGGGTGGGCGAGTTCGCGCAGGAGCTGGGCGAGCGCGCCTTCGCCACCGTGCCCGAGCTGCTCGCCGACCTGCTGAATGAAGTCCGTGACGGCGACATCGTGCTCGTCAAGGCGAGCCGGGGCATTTCCCTGACCCCGGAGCAGCGCGCGGTGACGGGCGTGGGGCTGGACGTGGTGGTGGAGGCCCTGCTCGACCAGCGCGACCGCTGACCTGCCGCTCACCCGGACCCGGCACAATCGGACCATGCCCCTCCCGCCCCGCTGGACCACACCGCGCCGCTTGCTTCGCCTTCCCGTGCTGGCCCTGCTGGGGGCCTCGCTGCTCGCCTGTGCCCCCGCGCCGTCTGCCGGGCGGGGAAGTGAGGCGGGAAGCACTGCCTCCGCCACTGGCGGGGTCCGCGCGGCCTTCAGCGACGATGGGGTGGCGTGGGTCAGTGGGGGCCGGGCGTGCGTGGCCCGCGTGCCGAGCTTTCAGCCGAGTTGCCCGCGCCTCGCCCCCGCCTCCGATGTGGGCTGGCAGCAGAGCGGTGGGCAGGGAGCCGACGCCTGGGCCGCGCTGCCGGGGCCGGGGCTGGTGGTCACGCTCGACCGGGCGCCGCGCAGCCTGAATGTGGGCGCGGTGGTCCTGCTGAGTAGCACCCGCATCTACCGCGAGGACGGCAGCGCCCTGACCTACAGCGGCGAAGCGGGTCGTGGCGTGGCCGGAGCGCCGCTGGCCGCCGTGACCGGGGGCGACGGGCGCGATTACGTGGTCCTGGGCCGCGAACTGCGCCGGGTGGACGACGGGGCAGTGCTTGACCGGGCGGCGCAGCCTTTCCTGTATGCCACCCCCAGCGGGGCCGCCAGTGCCGCCCTGCCCACCGCCAGTGACGGCCTGAGCCTTTACCGGCTGACCGGCAGCACCCTGGAACGCTTCAGTGCCGGGCAGGTGGTCGCTCGCGTGTCGCATGGCCCAGGGCAGGTGGGGCTGGTGCGCGGCGAGGTGGTTACGGTGGACGCGGCGGGCCGGGTGCGGCGATTCACTCTGCAACTCGAGCCGCTGAACTGAGCCTGGGACGCCGGGTTTCGGTGCCCTGTCCGTAGCTTGCGAGGGGCCAACGAGCGGCTCACCGACGCGCTCCGGCAGGGCCTGGGGGTGTCAGAGTTCCGTAAGCGGGGGGATGGTTCCATGGGCAGCGGTATGTCCGCCCTTGCCCTCACTCGCCGGCTTATTCCCGCAGCAGCTTCTGCCCGTTTCCGGAGCGTGGCCCAGGCCCCCGCATCGTTGCCGGGGGGGCCGGCCCGGGTAGATGAGTGAATGCTAAAATTCGCCGGACTCTGGAGGGAGCATGACGAGCCTCATTAACCGTTTTCGCAGTCGTTCCGCCGCCATCGGCGTGGAGATCGGCACCAGCACCATCAAGGTGGTGGCCCTTAAGGCAGGGGCCCCGCCTTCCCTGCAACACGCGGTGATGGTCCCCACCCCCATCGGCAGCATGCGTGACGGTCTGGTCGTCGAACCCCAGGCAGTGGCGAGCGAACTCAAAAGCCTGCTGGCCGAGCACCGCATCACCACCCGCCACGCCGTCACCGCCGTGCCCAATCAGGTGGCCGTGACCCGCAACATCATGGTGCCGCGCATGGACCGCAAGGACCTGCAAAGCGCCATTCGCTGGGAAGCCGAGCGCTACATCCCTTACCCCATCGACGAGGTCACGCTCGACTTCGACCTGCTCGACGACCCCGCCAACGTGCCCGAGGACGGGCAGATGGAAGTGGTCATCGCGGCGGCGCCCACCGAGGCCGTGCACCGTCAGATCGAGGTGCTGCGCCTCGCGGGCCTCGAACCCACCGTGGTGGACCTCAAGAGCTTCGCGGCGCTGCGGGCGCTACGCGGCAACCTGCTCGGCGAGCACCTCACCAAGAGCACCCTAACCGGCACCAACTACACCGAGGCCGGCGAGGTGGCGCTGGTGATGGAAATCGGCGCGAGCAGCAGCGTCATCAATCTGGTGCGCGGCGACCGCATCCTGATGACCCGCAACATCAACGTGTCCGCCGACGATTTCACCACTGCGCTGCAAAAGGCCTTCGACCTCGACTTTGCCGCCGCCGAGGATGTCAAGCTCGGTTACGCCACCGCCACCACCCCCACCGAGGACGAGGAAGACCTGCTCAACTTCGACCTCAGCCGCGAGCAGTACAGCCCGGCGCGCGTGTTCGAAGTGGTGCGCCCGGTGCTCGGCGACCTGATCACCGAAATCCGCCGCTCGCTGGAGTTCTACCGCGTGCAGAGCGGCGACGTGGTCATCGACCGGACCTTCCTCGCCGGGGGCGGCGCCAAGCTGCGCGGCCTGGCGGCGGCCATCGGGGACGCGCTGGGCTTCGGGGTCGAAGTCGCGTCGCCCTGGCTGACGGTGCAGACCGACCAGGCGGGCGTGGACACCGGCTACCTCCAGACCAACGCCCCCGAATTCACCGTGCCGCTGGGACTGGCGCTGCGGGGGGTGATGGGCCGTGGTTGAAATCAACCTCTTGCCCAAGGAGTATCGCCGGCAATCGCAGCCCAGCGTGTGGAAATACGCGTCCTGGGCGGCGGCTGGCCTCACGGCGGCGGTGCTCGGCGGCTGGTTCCTCTCGGTGTCGGGCGACACCAATCAGTTGCGCGAACGCTCGGCGGCGCTGCAACAGCAGATCGACGCGGTGGCCCCCCAGAAGTCCCGGTTCAACGACCTCACCGCCCAGCAGGGCGAACTCGAGCGCGTCACCCAGGTGGCGACGCAACTGCGCGACCAGAAGACCTACTGGTCCAACGACCTCGCGTCCTTCGTCGAGCGCGTGCCGGGCAACGTGGTGTTCAGCAACGTCAACATGTCCACCGTCGCGCCCGGTGCGGAGCCCAGTCTCGCCTACGCAGGCAAGCCCGTAACCCGGCAGCTTGACCTCACCGGCAGCGCCCGCAGTCAGGAAGCGATTGTCGGCTTCCTCAACGCCTTTGAGACCGACAGCAATTTCGGCGTCGATTTCAAGGGGATGCAGCATGACGCTACCAACGGCATCTACACCTTTACCGCCAGCATCGGGGTTGTGGGCGATCAGCCGAGCGCCGCGCCGGGGGCTGACCCGACAGCGCAGGGCGCGCCTGCCACTGGAACGGCACCGGCTGCCCCAGCGGCTCCTGCGCCGACGGCCACCACCCCCGCTGCCGCGCCGGCCCAGGGAGGTGCCCAGTGAAAGCCATCAAGCTCGCCCCCCACTACATCTTCGCGCTGGTTCTGACCCTGTGCTTGGTGCTGGGCTACCTCTTTTACACCATGGCGATTCAGCCCCGGCAACTCGAAATCACTTCCCTCAACGACGAGATCACCAACAAGGAAACCACGCTCGCCGCCGATCAGGCCAAAGCGGCGCGGGTGCCGACCTTGACGGCTGAAGTGGCCCGCCTCGAAGTCGAGCGCGAGAAGTTCCTGCGGGCGCTGCCGCCCACCGCCAACTTCGGTCAGGTGGTCGCCAACCTGCGCCAGACCGTGAGCGCCGCCGGGGGAGACCTCAAAACCCTCAATTTCGCTGGGAGCGGCGCGGCGGGGGCCAACCTGCCGGCGGGCGTGCGCCCCATCGGCATGACCATGTCGGTCAATGGCCGCTTTCCGCAACTGTTCCAGATTCTGCGCAGCCTGGAACTGCAAAACCGCTTTACCACCGTGGACAACGTGAGCCTGCAAACCCAGGGCGACGCCGGCACGGGCGGGGGCGGGACGCTGGGCAGCACCCTCGGCCTGACGGTCTATACCTTCGATGCGTCGGGCGCGACGAGCACCCCTGACGCGGCGGCTCCGGCAGCGGGCACGCCGGCCCCCGCTGCACCGGCCGCTGGAGGCACGCAACCATGAGCCGTTTTCCCACTGAAGACCAAACCCAGACCCAGACCATGACCGAGGTCACCAACGTCTCGCAGGAGAAATCACCGCTCAACCTCAACTTCTCGCGCGAAGTCAAGCTGGTGCTGGTGGTGCTCGGCATGGTCGCCCTGATCGGCGGCTGGTTCGTCCTGACCGGCCAGCCCGACGACCAGACCGTCACCGCGCCGGTCCCCGTGACTACCCCAGCCCCGGAGACGGCCACCACACCTGAAACCGCGCCGGCAGGAAATGCGGCCCCGGACGGTCAGACGGCGGGCACGGCCACAGAGACGACGACCACCCCAGGCACTACAGATGAGTCGTCCGGCAAGAAGGCGACAGGAACAGCCGCCAAGTCGCAGAAAGGCACGCAGTCTGGCGACGGCTCCGACGAAAGCCTGGTGGCGACGGTGCCGCCGTTGGAGGGTGAAGGCACGGCGACCCCACCGGTGCCCGTGCCCGGCGGCATCAACCCGGACCGCCCGCTCAAGACCCTCAGCGGCGCGGACCCCTTCGGCTCTCTGACGCCCAGTCCGGGAACCGGCACGGCTGGCGGGACGGCTCCAGCCACCCCGGTCGAAGCCCAAACTCCGGAAACTCAAAGCCCGGAGACGGCGCCCGAAACGCAGGCACCCACCGCGCAGAGCACTACCAATAGCCCAGCCCCGGTGGTCCTCAGCAGCCCGGCAGGCAGCAGTGTCAGCGGGCAGGGCGGCGTGCTCGATTACTCCTCGCGCCTCGATCAAGGGGCCCTGCCGACCCCTGTGATCCCAGTATCTCCGACGGAAGTCCGCAGCCCGGTGACCAGCGCTCCGGTCAGTGGCAGCTCAGTCAACGGCGACAGTGTCGGCAGCGGCATGGCGACAGCGCCCACGGTTGTGGTGAGCACTCCGGCTCAGCCCACCACCACTCCCTCGGCTTCAAGCCCAGTGGCTCGGAATACAGCGGGCCAGAGCGGAGCAGGACAGAACACGGGCGCCTCCCGCCCGGCCAGTGGCACCCCGTCGCGGGCCAGTGCTCCCAACGTGGTCGTCGTGCGTCCTCCGGCTCGCGTGTCCGGTACTTCGGCGGCGGGCGCGACGGGCAGCTCACGCACCGGCGCGGCGGGCACGCCCGCAGCAACGCCGACGCGCAACCAGTCTGCGTCCGGCACCCGCCCCGCGTCCGGGCAGACGCCGCCCCGAGTCATTGCGGTGGCCCCGGCGGGGGGCGCCCGAACTCCGGCAGCCCCCGGGAACAGACCGGCGACCGCCGCACCGACCCGGCCCAGCCCTTCCAGCACCGCTCCCAGCAAGACCGTCGTGGTGCGGCCCCCGGTCCCGGTCAGCGGGCAGCAACCGCCCCGCGTCGTGACCAGCCCCGCTGCGGGCGTCCCGGCGGGCAACGCAGCCCCAGCGCCGACCCCGCCTCCAGTCGTGGCGGCGCGGGTACCCCAGGCGAACACCGTGCCTGAGCTGGTGGCCCAGGCGGGCACGTCGGCGGCCCCGGCCACTTCCGGTGCGTCCGCCGGAACGGGCACGGCTGGTCAAGCGGGCAATGACGCCGCTGGCACGGCGGCCCTACCTCCCCTCATCACGGCGGTGGGCAGCGAGGCGGCTCCGGCCAGCACCGCTACGGCGGACGCAGGAAGCAGCACCCCGGCGGCGCCGGCAGCGACTGCCCTCGACCGCCTGCTCGCGCCGGGTCAGGTGGCCCTCAGCTCGGTGGTGCTCGGCCCGACCAACACGGCGGTGTTCCGCACGCCGCAGGGGTTCGTTGTGGTGGAGCAGGGGCAGACCGTCCCCGGCCTCACCGGCGAAGACGGCACCCCGGTCGTCTTGCAGAAAGTAGAAACCGGCGCCGTCACTGTGGCGCTTGGCACCAAGGTCAAATCTCTGGAACTGGAACAAAGGTGAGCCATGAATAAACGACACGCCCTCCTCTTGACTGCCGTGCTGGGCATGGCCACCGCTTATGCTCAAACTGCACCGACCACCACGACCGTCAATACGTTGCAGACGGTTTACCGTGACCCTAGTCTGACCTCTGCTCCAATTACAGCAAATGTAGGTAAATACGTCGGCCCCCTGTCTACTTTCTTGGCAAGCATCGCCAAATCGGCGGGCTACGAAGTGGTTTTCAATTTCAATATTGATGCGCTGGCCCTCATCAACGGTGAAATTGTTTTTGGAAATAGTACCGCTTCAGTGACGACTTCCTATGCAACTCCTTTAGGTAGGCCCCAGGAATTACCAGCCAAACCTGTAGTCCACAATTTCTCGAACGCTCCTTTCAACGAAGCTTGGCCTTTGCTTATGGATGTTTATGAGTTGGATTATCAACTAGTTAAAGTTGGTAGTGCAAATGTCATACGAATTGGTCAAAGGCCTAAGCAGTTGGCTCTGCCCCTAAAATTTATTTCGGCAGAGAGTGCCTTAACTGCCATTGAGAAATTTTTTGGTGAAGAAAAGTTTGAGACCGTGATAAGTTTGGATAGCAATAATAAACCTTTTCAAACTACTCGGCCAACAGGTAAATTTGGATTGCCTAATAGCATAAAAGTAATCCCCGATTCCAGCAATAAGCGTTTGATTATTGGTTCCAATAGTGAGGATGGAATAAGAATACGTAGTTTCGTAGAAACAATAGATGTACAATCCTCTGGTAAAGTAATATCTACTGATTCCATAAGCGAAATATATATTGTAAGAGGCCAGAAAGAAAGCGTATTACAGTTTTTGAGAGATAGTTTTCCGGAATTAATAGTTACCGATTATGCATCTGGAGGCCTTGCTATTGAAGGCCCACGAACAAGTGTTAACAGGGCTATAATCTTGCTTGGACAAGTAGACCGTGCACCTGAAATTCCTATTGTGCAGCGCATCTACACCGTGCGCGGCCAGGCCGCCGACATCACGGCGCTGCTCGCTGCCCAGTACCCTACCCTGCGCGTGACCCCGGTGGGGCAGACCGGCCAACTGGTGCTCAACGGCGCTCAGGCCCAGCTCGACACGGCGCTCGCCCTGCTCGAACAGGTGGACCGCCCCGCCCCGGTGGCCGAGTCCCGTACCGTTCAGCGCGTCTTCCAGCTCGTCAACGCCAGCGCTGAGGAAGTCAAGGCGACCCTGGAAGGCACCCTGGCGCGTGACCTGACCGCCGACAGCAATAACGACGTGCTGCCCAACGTGCCCGTCACCGCCACCGACGCCAACGGCAACACGACCGTGGTGAGCGTGCCCAACGCGCTCGGCAAGACGGCGAACCAGGGCACGGCGAATGCTCAGGCTCAGACTGCCCAGACTCCGGCCAACACCCAGCAGGCGACCCTGATCGCCGACAAGCGCACCAACAGCCTGATCGTGCGCGGCACGCCCGAACAGGTGGCGCAGGTGGCCGAGCTGGTGCCGCAGCTCGATCAGGTGGTGCCGCAGATCAACGTGCAGGTGCGGATTCAGGAGGTCAACGAGCGAGCGCTGCAATCGCTGGGCCTCAACTGGCGGGCGACCTTCGGTGGCTTCAACGTGGCGGTCTCGGGCGGCACCGGGCTGGCGGCCACCTTCAACCCCACCCAGAGCTTCCTCGGTTTCAACATTTTCCCGACCCTCACGGCGCTCGAAACCCAGGGCCTGACCCGGCGCGTGTACGACGGCAACGTGACCATGCAAAGCGGCCAGCGCTCGCTGAGTGCCACGGGCGGCGCCCAGAACGCTTCGAGCGGCGCGGCGGCCAGCGTCAAGAGTGGGGGCCGACTGGAAATCAACATCCCCTCGGCGGCGGGCAACATCGTGCGGCAGATCGATTACGGTCTCAACCTCGATTTCTTCAGCCCGCAGGTGGCGCCCGACGGCACCATCACCCTGCGTATTCGCGGTCAGGTCAACCAGCCGGCAACGGCGATCACCGCCGACAGCCTGCCCAACCTCATCGACTTCACCAACAGCGAAGCGCAAAGCACCATCACCTTCAAGAACGGCCAGACCATCCTGATGAGCGGCCTGCTCGGCAGCACCGAGACCACCAACCGCAGCGGCGTGCCCTTCCTGAGCAGCCTGCCCGGTGTGGGCGCGGCCTTCGGGGAAAAACGCACCGAGAAGACCCAGTCGCAACTGCTCGTCATCATCACCGGCACCGTCGTCAAATAACGCCTAGAGCAGTTCTCCGAATTACGCGTGCGTCGGAACAGCACCGCCACCCGCTCCATTCTCTGCTTCGCAGCTTTGCAAGTCCGTTCTGCTCCGTGTTTGTACTCGCTCTGCTCGCCAAAAAGCTGTGCCATCTTTTTGTCAAATGCTCTACGTCATACCGGCGCCTTTCTGCGAAGGGGCGCCGCTTTTTTGACTCTCGCGGCGGAGCCTGTTTGCTCAAGCCGCCGCGCCGGGGCCGCCAATCCCGCTACAGTCGCCCTATGAGGTACCTGACCGCCGGAGAATCGCACGGGCCACAGCTCACGGCCATTATCGAGGGGCTGCCCGCGCAGTTGCCGCTGGGCAAGGCCGACATCGACCCCTGGCTGAGAAAACGGCAGGGCGGCTACGGACGCGGGCGACGCATGGTCATCGAAACCGACGAGGCCGAGCTTCTGAGCGGCGTCCGTGCGGGCCGCACCACCGGCGCCCCCGTCACCCTCGCCATTCAGAACAAGGACCACCGCAACTGGACTGAAATCATGTCGCCTGAGCCGGGAGGCGAGCCGCGCAAGAAGGCGCTGACCGACGCCCGCCCCGGCCACGCCGACCTGACCGGCGGCATCAAGTACCGTCACAAGGACCTGCGCGACGTGCTCGAACGCGCCTCGGCGCGCGAAACGGCGGCGCGGGTGGCGGTAGGCAGCATTGCCCTCAAGCTGCTTTCTGAACTCGGCATCGAGGGGGCCAACTATGTCTTCAACCTTGCTGGCATTGAAACGCGGCAGGCCTTCTCCTGGGACGCACTCGACGCCATCGAGGACTCCGACCTGCGCACCCCCGATGCCGACGCCGCCGCGCAGATGCGCGAGCGCATCGACCAGGCCAAGAAGGACGGCGACACCCTGGGCGGCATCCTCGAAGTGCGCTTCCGGGGCCTACCGGTC
+>9_3#NODE_13_length_39994_cov_62.9723_ID_25
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GGTTGCGCAGCGAACCCATCATGTCGCTGCCGTCGGCCACCGGCAGCATGCGCAGCGCCAGCGCCACCGCCGCCCCACCGCTGCTGCCGCCGGCGATCCGCGCCGGATCGTAGGCATTGCGGGTGGTGCCGAACAGCGGGTTGTAGGTCTGCGAGCCGAGCCCGAACTCCGGTACGTTGGTCTTGCCGATGACGATCGCACCGCTGCTCTTCACCCGCTCGACGACGATGGCGTCGTGCTCCGGCACCTGCCCGGCGAACAGCGGCGAACCCAGGGTGGTAGGAATGCCGGAGGTGGCGGCGAGGTCCTTGATCGCCTGCGGCATGCCGTGCATCCAGCCCAGCCATTCGCCGCGCGCCAGTTGCCGGTCGCGCTCGTCGGCCTGGGCGAGCAGGCGGCTTTCCGCCTGCAGCGAGACGATGGCGTTGACCCGCGGGTTGAACCGTTCGATCTGCGCCAGGTAGGCCTGCATGACCTCGCGGCAGGACAGTTCGCGTCGGCGGATCGCCGCGGACAGCGGCAGCGCGTCAAGCGCGACGATTTCCTCGTGGCCGTCGCTTCGATGGCGGGTGGCGCTCATTCACAGACTCCTTGCCGGCTTGCCCAGGGCCGGTTCACGGGGGCGCGGGGCGGGCGTCGCGCCCTCCCGCAGATAGAGGGTGGCGAGCAGCCCGAGGAAGGCCGCGCCGAGCACGTAGAACGCCGGCGCCACTGGCGAGCCGCCGACCTCGGTGAGCCAGGTGACGATGAACGGAGCGAAACCGCCGAACAGCATCACCGCCAGGTTATACGCCACCGCCAGGCCGGTGGAACGCACCCGCACCGGAAACTGCTCGGCCACCGCGGTCGGCGCCGGGCCGAAGAAGCCGCCGATCGCCGTGCACAGCAACAGTTGCATCAGCAGCAGGCGCCCCAGGCTCGGCGCCGCGGCGACCCAGGCGAACAGCGGATAGACCATGAGCATGAAGGCCAGGGTCGCGACCAGCAGCACCGGGCGCCGCCCGACCCGGTCGGAGAGTCCCCCAGCCAACGGGATCACCAGGGTCATCAGCGCCACCGCAGCCATCTGCACCATGAACACCTCGTCCAGCGGCAGGCCCAACTGCTTGTGGGCGAAGGTCGGCATATTCACCAGCACCACGTAGAAGGACACCGTGCCGATCACCGTCAGGCCCATGCTCACCAGCACGCTGCGCCGGTATTCGCGCAGCACGCCGAGCAGCCCCTGGCGCTCGCCGGGCTCACGGATGGCTTCGAGGAAGGCCTCGGTCTCGCCCATGTAGCGGCGGATCCACAATCCCACCGGACCGATCAGCAGACCGAACAGGAACGGCACCCGCCAGCCCCAGCTCTCCAGGGACTCGGCGTCCAGGCAATGGGTGACCAGCGCGCCCATCCCCGCACCGGCGAACACCGCCAGGCACTGGCCGAACAATTGCCAGGAACCGTAGAGACCGCGCCGGTGCGGCGGCGCGCTTTCCACCAGGAAAGCCGTGGCGCTGGCGTACTCGCCGCCGGTGGCGAAACCCTGCAGCATTCGCGCGATCACGATCAGCAACGGTGCGCCGACGCCGATCGCCGCGTAGGTCGGGGCGAAGGCGATCATCGCGATGGACAGCGTCATCAGCAGGATGATCAGTTGCATCGCCGCCTTGCGTCCCCTGCGGTCGGCATACAGGCCGAGCAGGACCCCACCGACCGGACGCATGAAGAAACCGACACCGAAGGTGGCCAGGGCCATCAACAGCGAGGTGTACTCGTCGCCGGAAGGGAAGAACAGCCTGGCGATCAGGCTGGAAAGGAAGCCGTAGACGATGAAGTCGTACCACTCCAGGGCGTTGCCGATCACGGCAGCCGCCACCTGGCGGGTACGCGAGGTACCGCTCGGGCAAGCGTGCATGGGAATCTCCTGGTAACCGGGGGAATGCCGGCGCGGCTCAGGCCGCGCCGTTATTGGCGGCAGTCAGTCGAAGGCCGGACGCCGCGGGGGCGGCCAGCCAGGTCTCGGCGAGCGCGCCCCAATAGGCCGCGCCCCGGACCAGGATGTCGTCGTTGAAGTCATAGGCCGGGTTGTGCACCATCGGCCGTCCTCTGCCGTTGCCGATGAACAGGTAGCTGCCGGGGCAGCGCTGTAGCATCCAGGCGAAGTCCTCGCTGCCCATCAGCTTCGGCGTGTCGCCGTCGACCTGCTCCGCGCCGGCCAGCTCGACCCCGACCTGGCGGGCGAACTCGGTTTCCTCGACGCTGTTGACCAGCACCGGATAGGCCGGGTAGTGCTCGATGCTGGCCTGGCACCCATAGCTGGCGGCCTGCAACTCGATGATCTGGCGAACCCGCTGCAGCACCTGCTCGCGCACCTGGCCGTCGAGCGCCCGCAGGCTCAGGCGCAGCACGGCGCGCTGGGGTATGACGTTGGCCGCCTCGCCGGCCTGCAATGCGCCGACCGTGACCACCGCGGCCTTCTGCGGATCGACGTTGCGCGCCACCACGCTCTGCAGGGCCATCACCGCGCTCGACGCGGCGAGCAACGGATCGACGCTCAGGTGCGGCATCGAACCGTGTCCACCGACGCCCTCCAGGGTGACGCTCAGCAGGTCCTGGGAAGCCATCATCGGTCCCGCGCGGAAGCCCAGGTGCCCGGCCTCCAGTCCCGGCATGTTGTGCATGCCGAACAGCGCATCGCAGGGAAAGCGCTCCAGCAGCCCGTCGGCGAGCATCGCCTCGGCGCCGCCCTGGCCTTCCTCGGCGGGCTGGAAGATCAGTACCAGGGTGCCGTCGAAACGCCGCGTCGCCGCCAGGTAGCGTGCCGCGCCGAGCAGCATCGCGGTGTGTCCGTCGTGGCCGCAGGCGTGCATGCGCCCGCCGTGGCAGCTGCTGTAGCCGAGCCCCGTGGCCTCGACGATCGGCAACGCATCCATGTCCGCCCGCAGGCCGAGCCGCCGCGTGCCGTCGCCCTGGCGGAGGACGCCGACCACGCCGGTGCGGCCGATCCCTTCGTGCACTTCGTAGCCCCAGCCGCGCAGGCATTCGGCGACCAGCGCGGCGGTGCGTCGCTCCTCGAAGCCCAGTTCGGGATGGGCGTGGATGTCCTGGCGCAGGCTACGCAGGTCGTCGGCGACCTCCTCGAGCCAGGCCACGATGTGTCGATGTCGAGCCATGCCGTCTCTCCTCTGGCCGGATTGCGCTCCGGTCTTGTTGGCGGGAGGCCCGGACGCAAGGCCGGCCGGGCGTGGTCACAGCTAAGCGCGGCACGCGGCGAAGGACAACGGAAGGCGGTTCCACTGGGTGGAACCCAAGGCCCGCGCCGCCCTCCGCCGGTACGTCAGAACTGTTCCGGCGGCACTTCGCGGAAGTTCAGCACGGCGAACACCGGTACCTCGGGAGTGATCGAGGGAATATTGGCCATCTCCTTCAAGGGCTTGAGCTTCTCTTCCAGGTCGAAGTCGAGCAGCTTCAGCAGCACCGGCTCCAGGGTCGCCACCTGGACCAGCCCTTCGCCCTGGCGGGTGACCAGCACGTCGGCCTTCAGGCGGCGCTGCTGGCCGTGCAGGTCGAGGGTGAAGTCGAGCTTCTCGACCCGCGACTGGCCGACCCGCAGGTCGTCGAAGCCGGCCATGTCCAGGCGGCTCTCCACGGTGGCCTCGGGGAAGCGCGAGGTTTCGAAGAAGTTGTCCTTCATTCGCTCGTCGCGCAGGGCCAGGCCGCTGTCCAGGGTGCCCAGCGGCACCACGATGCGCGCGACGCCCTGCTTGTCGATCTGGCCGCTGAGACGATCGAAGCGCTGCACCTCGGCCATCTTCGCGCGTTTCACGGAAACGAAGCTGATCCGCGAGTAATCCGGCTCCAGTTGCCATTCCGCCGCCGACAGCAGAGGGCTGAGGAGCAACAACAGGACACACAATACAACAGGCATTCCACCTCCGGCTTCGGGCCGGCGCCGTCCCTCGCCCCGCGCCCCGACATGCGCCGCCGGTCAGTCCGGCAGCCTGTCCGCCTCGGGCATGAGCCGGCATCCCTCGCGCGGGCCCAGCCAGGCGGCCGTCTGCGTACTGCCGAGGCCGCGGGCGGTCACCCGGCGGCGGGCTTCGTCGTCGAAGAAGCCGCTGATCGGCACGTACTGTTGGGTATAGGCCCGGCAATAGTCCGCGGAGTTCCCCATCACGTAGCGGCAGGAGCAGTACTCCTTGGCCGTATAGGCGCCGATGATGGCGGGAAAGGCCGCCAGGTGGATGCGGTTCTGCCAGGCCCACGCGAGGGCGGCGAGCAGCCCCAGGACGAACAGGAAGAGCAAGGGATGGCGACGGATCATGGCCGCGCCTCCCCGGCGAACGCCGCCTGTGCCAGGCGCAGGAATTCGTTGTGGCGGAAACGCCCGTCGCGGTCGTCGGCGTAGCGCACGATCACCAGCTTCTCCTCGGGCAGCACGTAGAGCGCCTGGCCCCAGTGGCCGAGCGCGGCGAAGGCGGTCTCGGCGACGTCCGGCCAGGGCGCCGGCGCGCCTTTCACCGCACGGTTCAACCACCACTGGCCGCCCGGCACCGCCTCGCCCTCCTCTTCCGCGCTCGGCCGGTAGCGGGCGAAGGGTGTCAGGTTGAACTCGACCCATGCCAGCGGCAGCAGTTGCCGCTCGCGCCAGCGCCCGTGGCGCTGCATCAGCAGGCCGACGCGCGCCAGGTCGCGGGCGCTCATGTAGACGTACGACGAGCCGACGAACGTGCCGGCGGCGTCTCGCTCCCATACCGCCGAACGGATGCCCAGCGGCTCGAACAGCGCGCGCCAGGGGTACTCGGCATAGTCCGCGCCGAGCATGCCGTGGAGGGCCGCCGCCAGCACGTTGCTGTCGCCGCTGGAGTAGCGGAAACGCCGGCCCGGCGGCCGGGCCTGCGGGGTTTCGGCGACGAAGCCGGCCATGTCGTCACGCCCACGGGTGTAGAGCATCGCCACCACGGAGGATTTCAATGGCGCGAACTCGTAGTCCTCCTGCCAGTCCAGCCCGGAAGACCAGTTCAGCAGGTGGCGCAACGTCACCTCGGGATGACGGGCGAACGGCGGGTAGTAGCGCGCCACCGGGTCGTCGAGCTGGAAGCGCCCTTCGCCCTCGGCGACGCCAAGCAGCGTGGCGAGCAGGCTCTTGCTCACCGACCAGGTAAGGTGCGGGGTCTCTGCACGGCTCGGGCCGGCGTAGCGCTCATAGACCAGACGACCGTCGCGGATCACCACTACCGCGTCGGTGCGGATGCCTTTACGACGAACATCGTCGCGACGACCGAAGGCATAGCGCTCGAATGCCTCCAGCGCCGGCCCCGCGGGCTGTTGGGCACGGGGCCAGTCGGTGTCGGGCCAGTCTTCGGCCAGGGCAGGGAGGGCGAATACCAGGGCCAGCGCGGCGAGGGCGCGGCGGGACAACGGCAAAGCGGGCATCGGCGGGCCCTCTCGACGGTCGAGGGGCAACCCTAGCATGGCCTCGATGACGCCAGGAAGCGCGGACTCAGCCTGGCATGCGGTAGTCGTCCGGGCCGAGCAGGTCGATGCCGCACTCGAGGTTCTCGATCCAGTAGAGGAAGGCGCTGATCATTTCCTTGCCGACGAAGGGCCGCCCGTGTTGCGGCACGATCATCTCCACATCCATGTCCCGGACCATCCGCGCCCACAGGCGGCAGATCTTGTTCGCCGCCATGTAGCGGCGATGGAATCCGTCCATGTACTGGATATGCGCGGCGAAATCGCTGACCGGCGCCGCGTCGTCCACCAGCGAGGCGCCCATATCGCCCGAGAAAAGGATCTTGCTCACCGGGTCGTAGAGCTGGAAGTTGCCCACCGAATGCAGGAAATGCGCGGGGATCGCCTTCAACGAGCAGTCGCCGAGAGCGATCGCCTGGCCGCGGTCGGGCAACGGCATGACCCGGTCGTAGGTGTTGATGCCATGGCTGACCGCCAGGTAGTTGGCCGTCAGGTGCGGCAGGAAGCGCGCCCACAGCTTGGAGCAGATCACCCGGGCGCGGGTGTGCAGCAGCCACTTGTCGAGGGCGGCGATGATGTCCGGGTCCTGGTGCGAAGCGAAGATGTAGTCCAGCTCCTGCAGCGGAAAGCGTTTCGACAATTCCAGCGAGAGCGGCGTGTAGGTCAGGTCGCCGCCGGGATCGAGCAGCAGGTACTGGCCGTTGTCGACGATCAGGAACTGGTTGGACTGGACCCCTTCGCCGCTGACGAGGTCATCGAAACACAGGCACTGGTGGCTGCCGTTGTCGAACAGCACGATCGGTTCGCGTCGCATGGTCGGTGAAATCTACTCTGTGCAGGCGCCGAGGAGCATTCCTCGCCGGATGCTGCGCAGGGTAAGCGCCTGCGGCGCGGCGCCTCACTGACCTGGGTCAAGCCCGAGGCGGGTCAAGGCCTTCTCCAGGCGAACTTTGCGGGCCCCGTTGGCAATCGCCAGCAAGCCGCGATCGCGTTGCCACAATGCCTCCCAGGTCGAGGCGTTGGCGGCGAAGGCGGCATCCAGTTGCCCCTCCAGCGCCGAGAACTGTTCGAACAGCCCAGCCAGTACCGCCTGGGTGCCGACGCAGGCGACCGGATGCCGCGCGACCTCGGCGCAGCCGCCGAGGATGCCGGCCAGGCGCAGCAGCAGCGGCGAGGGCCAGCCGCATTCATGGCCGACCCCATAGAGCCAGCCGACCAGCGCCGCCAGCACATGGACATCCTCCAGCAGGCGGAACGGCCTGACGTAGTCGTCCCAACCATCGCCGGGCAGGCGCTCGCAATGGGCACCGTCGAGCAACAGGCGGGAATGCGGCACATCCGGCATCAGCGGCAGCGCCGGCAACGCCTCCAGGCGCGCCCCCGGGGCGCCGGCCAGGACCACCGTCATCGACAGTCGCGGCGGCTGCCCCGGCGCCTCGTCGCGGGCGGCCACCAGCCACCAGGAGGCGCTGTCGCCAGCGGTGACGAAATCCTTTTGTCCATGCAGGACCAGCCCCTCCAGGCGGGTCTGCAGGTCCGCCGGGCGCACGCTGCGCTTCTCGGTCACGCACAGCGCGCCGAGACCTTCCGGCGCCGCCGGCCAGAGCGCGCGCAGGGCCGCCTGGTAGCCGGCGAGGAAGGCCAGGCCCGGACTCGCGGCCAATCGTCCGCCGAGCACCGCCCGCTCCAGGGTGCCAAGACCGTCGGCGCGCGCCAGGGCGGCGGCGTGCCAGTCTTCCAGGGAGCCTTCGGTGGGCAGGCGGTCGAGCGGGCCGAGCAAGCGTTGCCAGGACATGGCGGACTCCAGTGTGGAATGTGTCGGAACCGGCATCCTGCCGAGGGTGCCAGCGTTGAACAACGGCGCGTTACATCCGGCGACAATGTCATACAAGCATCACGCCCCTGTCACAGGGGTGACACCGCGCCTTCCTAGCCTGAGCTTGCACAACAAAGCCGAGCGGCCGCAACCCGCGGCGCCGGCCCAAGGAGGCCCAGGCATGACCCAGACCGCCATTACCCGCGAACCCGTCGCCGGACGCCGCCTGAAGGCCGAGCGCCTGAACGGCGCCCGCGCCCTGCGCGAGGCCCAGGCCCTGCGCTACCGCGTATTCAGCGCCGAGTTCGACGCCAAGCTCGAAGGCGCCGAAGACGGCCTCGACCGCGACGACTACGACCGTCACTGCGCGCACATCGGCGTCCGCGACCTCGACAGCGGCGCCCTGGTGGCCACCACCCGGCTGCTCGACCATCGCGCCGCCGAACGCCTCGGGCGCTTCTACAGCGAAGAGGAGTTCCACCTCTCCGGCCTCGACGCCCTGCACGGCCCGGTCCTGGAGATCGGCCGCACCTGCGTCGCTCCCGAATACCGCAACGGCGCCACCATCGCGGTACTCTGGGGCGAACTCGCCGAGGTCCTCAACGAGGGCGGCTACCGCTACCTGATGGGCTGCGCCAGCATTCCCATGCGCGACGGCGGTATGCAGGCCAAGGCGGTGATGCAGCGGCTGCGCGAACGCTACCTGTGCACCGACTACCTGCAGGCCGAGCCGAAGAACCCGCTGCCGCCGCTGGACGTCCCGGAAAACCTCACCGCCGAGCTGCCGCCGCTGCTCAAGGCCTACATGCGCCTGGGCGCCAAGATCTGCGGCGAGCCCTGCTGGGACCCGGATTTCCAGGTCGCCGACGTGTTCATCCTGCTCAAGCGAGACGAACTCTGCCCGCGCTACGCCCGCCACTTCAAGGCAGCGGTCTGATGGCGCGGCTGCGCCTGCTGCTGCGCAGCGCCCGCCTGCTCGGGCTGGTCGCGCTCGGACTGGGCCTGGCCGCTTGGGTCAGCCTGCGCGAGCGGCTGCCCGGCGCCGACGTCACGCCGTTGCGCCAGCGCCTGACCCGCTGGTGGCTGGCGCGCCTCTGCGCGGCCCTGCCCTTCGAGGTCAGGGTCAGCGGCGAAGCGCCCCGGCAACCCATGCTGTGGGTAGCCAACCATGTGTCCTGGACCGATATCCCGCTGCTCGGCGCCCTGGCGCCGCTGACCTTCCTGTCCAAGGCCGAGGTGCGTGCCTGGCCGCTGGCCGGCTGGCTGGCGGAAAAGGCCGGCACCCTGTTCATCCGCCGCGGCTCGGGCGACAGCCGGCTGATCAACCAGCGCTTGGCCGAACAGCTGCACCGCGGACGCAACCTGCTGATCTTCCCGGAAGGCACCACCACCAACGGCGAAAGCCTGCGCACCTTCCACGGTCGCCTGATGGCCAGCGCCCTGGAAGCCGGCGTGGCGGTGCAGCCGGTGGCGATCAGCTACCGCCGCGACGGCGTGCCCGATGCGCAGGCGCCGTTCATCGGCGACGACGACTTGCTCAGCCACCTCGGCCGCCTGCTGCGCGGCGAGCGCGGCAGCGTGCATATCCAACTGCTGGAACCGATCCCCAGCCAGGGCCTGGACCGCGCCGAACTGGCCCGCCAGGCCCAGCAGGCGGTGCGCCTGGCGCTGTTCGGCACTGCCGCCACTACGCAAACCCGGCGCGCCGCCTAGTCGCGCTTGGGCGGCACCGCCAGCACGTCGCACGGCAGGTCGCCGAGGGCCGCCTCGGCCACGCTGCCGATCAGCGCGCGGCGGAAGCCGGTCAGGCCCTGGGTGCCGAGCACCGTCAACTGCGGCGCCTGGCGGCGTACCTCGGTCATGATCACGTTGATCGGCAAGCCTTCGCCGACGCGCAACTGGATGTCCTCGCGGCCCAGCCCCAGGCCGGCGACGTAGTCGCGCAGCTCGACGTTGGCCTTGAGTTCCTCCTGGTCGACGTAATGCTCGACGCGGTCTTCCTTGATCCCCGAATAACGCATCATGCCTTTGGCGAACGGCTCGAAGGCATGCAGCGCGGTGAGGCTGGCGGCGTCGAGGAAGCCGAGCTGGCCGGCCATCTGCACCGCGCGCGTCGAGGTCGGCGAGAAGTCCAGCGCCAGCAGCACCCGGCGGTACTCCTCTTCCGGCGCACCGGCCGCGCGCAGCACCGGGATCTTCGCATTGCGTACCACCCGCTCCAGGGTGGTGCCGATGAACAGGTCGCGCAGCGGCGTGTGCCGGTGCGCGCCCATCACCAGCAGGTCGGCGCCGATCTCCTCGGCCACCGCGTTGATCACCACCACCGGATCGCCGACCCGCACGATCGCCTTGGACTCGACGCCGAGGCGCTCCTTCAGGGCCTGTCCGTTCACTTCCAGCAGGTTGGCGATGGCCAGCCGTTGCGGCGCGATCAGCACCGGCGGCTGGTCGTCGTCGAGCACGTTCAGCACGGTCAGTTCGGCATTCCTCGCCTTGGCCAGCGCCGCGGCGCGCATGACCGCCAGCTCGGAACGCGAGGACAGGTCGGTCGCCACCAGGATTCGTTTCATCTTCCACCTCCATTGGCAGAGCGTTGAACGTCGGCCCCATTGAACGATCGACGCGACCGCTGCCGGTTGATGTGCATCAAGCGGATGCTTCGGACTGAAACAATTGATAGGTGATTCCGCCGGCCGGGCCAATGGCCGCTGCGCCAGGCTCAGCGCTGGCTCAGGGCGAAAGCCTGGAGTTGCGGGTAGAAGGCGCGGAAATCCGCGCTCAGGTCATCGTAGCGCTGGGCCAGTTCTTCCCAGGAACCGTCCAGCAGGTGCGGTCGCGACAGCCTCCGCGACATGCCGCCCAGCACTTCGCGCAAGACCGCGAACTCGCGGTAGCTGCCCAGCCAGTCCTGGGCCGCCATCCGCGGCGCGATGCGCGCCAGGCGCTCCGGCAGCGGCGAGGCGGTGCGCAGAGTGCCGTAGACCCGCTCGACGAACTGCGGCAGCGGTTCGTCGGCGTAGTCGTTCCAGTCGCGCGCCAGGCAGTGGTCGAAGAACACGTCCAGCAGGACGCCGGCGAAACGCCGGCGCTCCAGCGGGAAGCGCCGCTTGGCCGCATGCACCAGTGGATGGCTGTCGGTGAAGGCGTCGATGCGCCGGTGCAACTGGATGGCCCGCTCGATCTCGCCCGGCCATTGTCCCTGCAGGCGGCCCTTGACGAAGTCGCCGTACAGGCTGCCGAGCAGTTGGGCCGGTTGCGGGCCGCCGAGGTGGAGATGCGCGAGGTAGTTCATGCGGGCTAGCTTACCCCAGGGACGGAACCGTCGTTTCGATCATCGTCATCAGCCCTGTCGATAGCGACTATCGTCGCAATCGATCCCCATATCGTCCCACACCGATATATAGTTCGTCCCAACCCGATATGGACGGCCAACGGACCACCGCCATGCCACTGGACATCGACGAAATCATCAAGGCTCTCTCCCACCCGGTGCGACGCGACATGCTGCGCTGGCTGAAGGAACCGGAGAAGTACTTCGTCGAGCAGGACCACCCGTTCGAGATCGGCGTCTGCGCCGGCAAGTTCGACCAGCGTACCGGTCTCTCCCAGTCCACCGTGTCGGTACACCTCGCCACCCTGCAACGCGCCGGTCTGGTGACCAGCCGCCGGGTCGGCCAGTGGAATTTCTTCAAGCGCAACGAGGAGACCATCCAGGCCTTCCTCGACCAACTCGGCGACGAGCTGTAAGCAGCACTCGCTTCCACCCCACCACCTCGCAGTCCAGGAGCTCGACCGATGCCGGCGTCTCTTCTCGTCCTCGCTTTATCCGCCTTTGCCATCGGTACCACCGAATTCGTCATCATGGGCCTGCTGCCGCAGGTCGCCGGCGACCTGCGGGTATCCATTCCCAGCGCCGGCTGGCTGATCAGCGGCTACGCCTTCGCCGTGGCCTTCGGCGCCCCGTTGATGGCCATGGCCACCGCCCGCCTGGAACGCAAGAAAGCCCTGCTCGCGCTGATGGGCATCTTCATCGTCGGCAACCTGCTCTGCGCGGTGGCCGCCAACTACGGCCTGCTGATGCTGGCGCGGATCGTCACCGCGCTCTGCCATGGCGCCTTCTTCGGCATCGGCTCGGTGGTCGCCGCCAGCCTGGTGGCGCCGAACCGCCGCGCTTCCGCCGTGGCCCTGATGTTCACCGGCCTGACCCTGGCCAACGTGCTCGGCGTGCCGCTGGGTACCGCGCTCGGCCAGGAAGCCGGCTGGCGCGCGACCTTCTGGGTGGTGACCCTGATCGGCGTGGTCGCCTTCGTCGGCCTGGCCAGGGTGCTGCCAAACGACCGCGAGGAAGAGAAGGTCGACCTGCGCCAGGAAATGTCCGCGCTGAAGAACCCGTCGCTGTGGCTGGCCCTGGGCACCACCGTGCTGTTCGCCGCCTCGATGTTCGCCCTGTTCACCTACGTCGCGCCGCTGCTCGGCGAAGTCACCGGGGTCAGCCCGCGCGGCGTGACCTGGACCCTGCTGCTGATCGGCGTCGGCCTGACCGTCGGCAACGTGATCGGCGGCCGCCTCGCCGACTGGCGCCTGGGCACCACCATGGCCGCGGTGTTCGCCGCCATGGCGCTGGTCTCGGCGCTGTTCAGCTGGACCAGCCAGGCCCTGCTGCCGGCGGAAATCACCCTGTTCTTCTGGGCCGCCGCCGCCTTCGCCGCGGTGCCCGCACTGCAGGTCAACGTGGTCCGCGTCGGGCATGCCGCGCCGAACCTGGTGGCGACCCTGAACATCGGCGCCTTCAACGTCGGCAACGCGCTCGGCGCCTGGGTCGGCGGCAGCGTCATCGACCACGGCCTGGGCCTGACCCGCGTGCCGCTGGCCGCCGCCGCGCTGGCCGCGCTGGCGCTGCTGGCCACCCTGATCGCCTTTTCCGGAAACGGCCGCGCCCAGGCGCAGCCGGTCCTCGATTGATCCCCTGTCCGTCTATTCCCTAGTGGAGGATGTTCCATGGCTACTCTGTTCGATCCCATCGTGCTCGGCGACCTCGAGCTGCCCAACCGCATCGTCATGGCGCCGCTGACCCGCTGCCGCGCCGATGAAGGCCGCGTGCCCAACGCCCTGATGGCCGAGTACTACGCCCAGCGCGCCGATGCCGGCCTGATCCTCAGCGAGGCCACCGCGGTCACGCCGATGGGCGTGGGCTACCCCGACACCCCCGGCATCTGGTCCGATGACCAGGTCCGTGGCTGGAGCAACGTGACCAAGGCGGTGCACGCCGCCGGCGGGCGCATCTTCCTGCAACTCTGGCACGTCGGGCGGATTTCCGATCCGCTCTACCTGAATGGCGAGCTGCCGGTGGCGCCGAGCGCCATCGCCGCCGAGGGGCACGTCAGCCTGGTGCGCCCGAAGCGTCCCTACGTCACCCCGCGCGCGCTGGACACCGAGGAGATCGCCGACATCGTCGAGGCCTACCGCCAGGGCGCCGAGCGGGCCAAGGCCGCCGGCTTCGACGGCGTGGAGATCCACGGCGCCAACGGCTACCTGCTCGACCAGTTCCTCCAGGACAGCACCAACAAGCGCACCGACCGCTACGGCGGCTCCATCGAGAACCGCGCGCGCCTGCTGCTGGAGGTCACCGACGCGGCGATCTCCGTATGGGGCGCCCAGCGCGTCGGCGTACACCTGGCGCCGCGTGCCGACTCCCACGACATGGGCGATTCCAACCGCCTGGAAACCTTCAGCCATGTCGCCCGTGAGCTGGGCAAGCGCGGCATCGCCTTCATCTGCGCCCGCGAAGCGCAGGCCGACGACAGCATCGGCGTAGCCCTGAAGAAAGCCTTCGGCGGACCCTACATCGCCAACGAGCAGTTCACCCTCGACAGCGCCAACGCCATCCTGGCCAAGGGCGACGCCGATGCGGTGGCCTTCGGCGTCCCCTTCATCGCCAACCCGGACCTGGTCGAACGCCTGCGCCAGGGCGCCGAACTGAACCCGCCGCGCCCGGAAACCTTCTATACCGGCGGTACCGAAGGCTACCTGGACTATCCGACCCTGGCCTGATCGCGCCAGCCAGGAAGAGCCCGCCACGCTTGTCGTGGCGGGCTCTGTGCTTTGCCCGTCTAGCGCAGGCGGAAATACGGCTCCGGCTCCGCGCACGGATCGCGCTGGGCGCAGCCCTTGCAACCGCCGCCGCAACCGCCCGAGCTTTGCGCAGCCACCCGCTCGACCTTGCCGAGCGCGATCAGCCGCTCCAGGATCGCCTCCACCAGCGCCGGCGGCGCGTCCACCTGGCGGCTGAGCTGTTTCAGCCCACGCGCCTGGCCGTCTTCCAGGGCGGCGCGGAGCTGCATGAGTGTCGCCATCAGTGACATCCTCCCTGCCCGCTCGGGGCATCGGCCATTCGGCCTGGCAGTTGCAGTACCTGCTCACGGCCGAACAGACGCAGGCAGGTCATCAGGATCAGGTTGAAGAGCAGCACCACGGCGATGGTCAGGACGCTACGCTCGGGGTGCGCGGCGAAGGTGGCGACCTGGTAGCAGAGGGTCGCCAGCGAGTAGGCGACGTTCAGCCCCCAGAGCACCGAGAAAGCCATCCAGCCCTTGCTGCTTTCCCGGGCGATCGCGCCCATGGCGGTCACGCAGGGCACGTAGAGCAGGACGAAGACCAGATAGCTGTAGGCCGCGATGGGGCTGCCGAACTTGCTCGCCATGGTGCCCATCGAGCCGGTCTCCATGTCGCCGTCGGCCATGCTCGCCTCCACCGGGTTGGCCAGCACGCTGAGGCTGAAGGTATCGACCAGGCCGTCCCAGGTCTCGACCAGGGCCTCGCGCAGTTGCCCGGGCAGGTCGTAGCCTTCGTAGTCGAAGGCCTCGCCCTGGATCTGCTCGGCGGTGTAGAGGGTGTTCAGGGTGCCGACCACCACTTCCTTGGCCATCGCCCCGGTGACCAGGCCGACGGTGGCCTGCCAGTTGTCCGGCTGCACCCCGAGCGGCGCCAGCAGCGGAGTGAGACGCTGGCTGACGCTGGCCAGCGCGGAATGGCCGATGTCGCCCTGCACCGGCTTGCCGTCGAGGGTGATGCTGTTCAGGCCGCCGATCACCAGGCTGACCAGGATGATCACCTTGCCGGCCCGCACCACGAAGCCGCGCAGGCGCGACCAGGTCTGCAGCAGCAGGCTCTTAAGGTGTGGCACATGGTACAGCGGCAGTTCCATGACGAACGGCGAGGCCTCGCCGCGCATCAAGGTGTGCTTGAGCAACAGCCCGGTGAGGATCGCCACGACGATGCCGAGCAGGTACAGGGAGAAGATCACCAGCGCGCCGCCCTGGCCGAAGAAGGCCCCGGCGAATACGGCGAAGATCGCCAGGCGCGCGCCGCAGGACATGAACGGCGCCATCATGATGGTAATCAGCCGCTCGCGCTGCGCGTCCAGGGTCCGCGCGCCCATGATCGACGGTACGTTGCAGCCGAAACCGACGATCAGCGGCACGAACGACTTGCCCGGCAGGCCCAGCGCCTGCATCAGGCGGTCCATGACGAAGGCCGCGCGTGCCATGTAGCCGGAATCCTCGAGCAGCGAGAGGAACAGGTACATCAAGCCGATCTGCGGCACCAGCGGCAACACCGTGTTGACCCCGCCACCGATGCCCTGGGCGAGGAACACCGTGAGCCAATCGGGCAGGCCGAAGCGGATACCCAGCCACTGGATGCCGTCGATGAAGATCGCCGACGAGCCCTTGTCGAAGATCGGCTGTAGCGCCCCGCCGATGTTGATGGCGAAGAAGAACATCAGGTACATCACCAGCAGGAAGATCGGCAGACCCAGCCAGCGATTCAGGACGACCCGGTCGAGCCATTGGGTCAGCCGGTGCGGCTGAGCCTGCTGGTGGTCGCAGACCGCCGCACAGATCTCGCCGATCAGTCGGTAGCGCGCATCGACGATCGCCAGCTCGGGCTCCTCGCCGCAGCCCTGGCGCGCCTGTTCCAGGGTGGCGGGCGGCAAGCCCAGCGCCGGGCCGTTGAAGATGTCGCCTTCCAGCGCCTGTAACGCCAGCCAGCGCGGCTCGATGGCCGAGGCCGCCGGAGCGCGCGTTTCCAGAAGGTAGCCGACCTGCGCCTGGATGGCCGGTGGGTAATCCACCGCCAGCGCCGCCTGCGGGAGCTGTAGGGAGTCGATGGCCGCCTTCAGTTCGTCGATGCCATCGGCGCGGGTGGATACCAGCGGCACCACCGGGCAGCCGAGACGCCGCGCCAGACCGTCGATATCGATGCGGATGCGCTGGCTACGGGCGATGTCGAGCATGTTCAGCGCGACGATGCAGGGGATGCCCATCTCCCGCAGTTGCACCGTGAGGTACAGGTTGCGCTCCAGGTTCGCCGCATCCACCACGTTGACCAGCACGTCCACTTCGCCGCTGGCGATGTAGCGGCAGGCGATCTGCTCGTCCAGCGAGGCCTGGGCGGAAACGCTGGTCAACGAATAGGTGCCGGGCAGGTCGACCAGGCGTACCGCGTGACGGACGGTATGGAACGCACCCTCCTTGCGCTCCACGGTGACGCCGGCCCAGTTGCCGACCCGCTGGCGCGAGCCGGTGAGCTGGTTGAACAGGGTGGTCTTGCCGGAGTTGGGATTGCCGATCAGGCCGAGGGTCAATGCGGTCATGGGGATTCCGGGCGGGGTCAGTCGAGCGGGACGAGGGTCAGCAGGGCGAGGTCCTTGCGCCGCAGCGCCAGGCTGGTCTGGCGGGTCTCGACCTGGATCGGGTCGCCCAGCGGGGCGATGCGCACCACGCGCAGCGCCGCGCCGGGCAGAAGCCCCATGGAGAACAGGCGTTGGCGATAGCCGTTGCTGATGGCGGGGGAATAACCGGTGATGCGGTAGGAACGGGACGGTTGCAATGCGCTCATGGCGGATTCCAGGCAGAGGAAGGGACCAATGGCCTCCCTGGCCGGTGACCGAGAATCTAAACGACTCTCACTTAAGGCTCGCTTAAGGACGCAGTATCGGAGTGGAGGAGCAGCGGATTCGCTGATCCAGAGCAATGGAAGCGGGGATTTTCGCCGGGCGCGGCGAACTGTCGCCGCCAGCGCCCGGTGCGACGGGCGGCTGGCGGCGCAAGGGGTCAGCGGGTATTGAGCTGCTGCTGCAGGTTCTGCACCTGGGCCTGGAGGGTGTTGATGTTGCGCATCACCTGGGTGCGGAAGGCGTCGAACTCGGCGGTATTGCCGCCCTGGGCCGGGCGGTTGTCGAGCTGGCTGCGCAATACCAGCAGGTCATCCTGGATACCCTTGATCGTCTGGCTCGGGTTGCCCTGCTTCTTCAGCGCCGCGACATCGCCGCCGAGGGCCTTGAGTTGCTCGTTGGTCTTGCCCAGTTCGACCTGCAGGGCTTTCAGCTTCTCCTGTTCGGCGGCCAGTGTCTGCAGCTTGCCGTCCAGTTGCGCGACCAGTTGCGCCGCGCTTTCCTGCTGGGCCTTGAGATCGCTGGCCAGTTGGTCGAGGCGTTTGCCCTGGCCGCCGAACTGGTTGCTCACATCGGCCTGCTGGCGTTCCTGGCTGCCGAGTTTCTCCTGCAGTTGCTTGACCTGCAGGCGCAGCGCCTCGCGTTCGCTGGTGACGCTGGACTCGCTGGCGACCACCTTGCCGCGAATGTCGTCGAGGCGCCCGGCGGCTTCTTCGCTGATCCTTACGAAGCTTTCCTGGGTCGCCACCAACTGCTGTTCCATCAGGCTGATTTGCTGGTGGCTCCACCAACCCACCCCGGCGAGGGCGATCAGCATCGCCCCGAGCAGGGCCCAGAGCGGGCCGGTAGAGGCCGGACGGCGCTCCTTGGTGTCGACGACCCGGCGCTGCTCCGGTTCGTAGACGTGCCGCGGGTGGTGGCCGAATTCATCACGGTCGGCAGCATCGGTGGTCAGGCTGGGCACATCGTCGAGTTCGTCGAAAGCATCGTTACGCATGGTGAAAACCTGTGAAGGGGAACGGCATCCTGCCGGAGGCCTGGAGAAAGGGCCGAATGGCGCATTATATCGGTTCGGCCCCGCCCCTTCAGCGTCTGCTCGAAGCAAATTGCCGGACCGGGGCGCTCCACCGCGAAGCCGTGCGCCCCAAGACGGAGCGAACGCTGTCCGGCACAGACCGCCGCAGGCCGCCAGCGGTTCCCCGCCCCGCACGCCGGCGCTGGTCCGCGGCCCGCATGGCACGTCGCTTGCTTGGGCATTGCCGGGCAGATTCGAGAGCCGGAGGATGCATGGAGTTGAACAAATCCTTGCTGGATTGCATGCGCGCCGTGCGCCGACGACTACGCGAGGAACAAGCGCTGGATATCCACTTCCAGCAACGCGATGCGATCGCCGCGATGCAGGCGGCCTGCGCCCGCTCCGGCGATGCGACGACGCGGGAGCTGGGACAGCGCCTCGGCAGGCTCAGCGGGGTCGCGCTGCCGCCGGCGGAACCTTCCCTGTTGCCCGCGCAGGCGCCGAGCCGACAATACGCCGGCCCGCTGCGCGGCTGATCAGAGTCCCTGGGCGCGCCACCAGGCGCAGAACTCGTCGAGCGCGGTCCACAGGCTGACCCGCGGGTCGTAGTCGAGGTATTCGCGGGCGCGGTTGATGTCCAGGGTGAAGTTCTTCGCCATCACCGCCATGCCCAGGCGGAACAGCACCGGCTCCGGGCGCCCCGGCAGGATCCGGCAGACGCCTTCGTTGAGCGCCGCCAGGCCATAGCCGACGGCATACGGCAGGTGACCGCCGACCGGCGGCAGGTCGAGCTGGCGCATCACGTAGTTGACCGCATCCCAGAACGGTACCGGCTGCCCGTTGCTGATGTTGTAGACCTTGCCCAGCGCCGGCTCGCCGGCCAGCAGGCAACTGAACAGCGCGTCGTTGAGATTGTGCACGCTGGTGAAGTCGACCCGGTTCAGGCCGTTGCCGAGGATCCGCAGGCGTCCCTTGCGGTGGGCCTGGATCATTCGCGGGAAGATGCTGGTGTCGCCGGCGCCGACCACGAAGCGCGGACGCAGCGCCAACACTTCCAGGCCCAGGTCGCGGGCGCTGAGCACCAGTTGCTCGGCCTGGTACTTGGTCGCCCCGTAATGGTCGGAAAAACGCCGGGGTACGTACTCTTCGTTCAGGTCCAGGTGGTCGCGCCCGTCGAAATAGATCGACGGCGACGACAGATGCACCAGGCGCCGCACCTTTTGCCGCATGCAGGCCTCGACGACGCTCTCGGCAAGCCCGACGTTGGCCGCCAGGAAGCGTTCGCGCGGTCCCCAGACTCCGACCGCGCCGGCACAATGCACCACCGCCTCGACATCCTCGCAGAGGCGCAGGACCAGCGCCGGGTCGGCGAGGTCGCCGGGAACGAACTCGGCGCCCCGCGCCACCAGATGTTCCACCGCGTCCGCACGACGACCGCTGACCCGTACCGACAGGCCCTGCTCCAGGGCGAAGCGAGCGAAACGCCCGCCGATGAAGCCCGTCGCCCCCGTTACCAGAATCCGCATTGCGTTTCTCCCGTTGTTCTTCTTGTGCCGCGACTCTAGCAACCCGGAGCCGCGCCACCACTGGCACAGCATGCCAGAACAACGACCTTGCGGGCCGCCGGCACGACTTGCGTTGGGCGACAGAAGCGGCGCTGCGCGCTACAAGGTCTAACCTGAAAGCCACCTGCACGCTGGGAGACGCACCATGGCCAGTCACTGGATGATCTACGGCGCCAACGGCTACACCGGCCGGCTGGTCGCTGAACAGGCGCAGCGCGAGGGCCTGACGCCGCTCCTCGGCGGACGCAACCCGGCCGCCCTGCACGCCCTCGGCAGTCAGCTCGGGCTGGAGTGCCGGGTCTTCGACCTGGGGGATCCGCAGGCCTGCCGCGAAGCCCTGGACCAGGTGAAGGTGGTGGCCCATTGCGCCGGTCCGTTCTCCGCCACCAGCACGCCGATGATCGCCGCCTGCCGCGCCGCCGGCACCCACTACGTGGATATCACTGGAGAGATCGCGGTGTTCGAGCAGGCCCACGCCGGCGACGCCGAGGCCCGCGAGGCCGGCATCGTGGTCTGCCCGGGCGTGGGCTTCGATGTGATCCCCACCGATTGCCTGGCCGCCTGCCTGAAGGAGGCGCTGCCGGACGCGCAACGGCTGGCGCTGGGCTTCGTCACCGGCAGCGGGCTTTCGACGGGAACCGCGAAGACCAGCGTCGAAGGCCTCAAGTTCGGCGGCAAGATCCGCGAGAATGGCCGCCTGCGCGACGTGCCGTTGGGCTACAAGCGCCGCGACATCGATTTCGGCCGCGGCCTGCGGCACGCCGTGACGATTCCCTGGGGCGACGTGGCCACCGCCTACTACAGCACCGGCATCCCGGACATCGAGGTCTACCTGCCGGCGCCGCCGCTGCTGGCCCTGGGCATGCGCCTGATCGATCCGCTGCGTCCGCTGCTCGGTCGGCAACGGGTCCAGGACTGGCTCAAGGGGCAGGTCGACAAACGCATCGCCGGCCCCGACCAGGCGGCCCGCGAGCGCCTGCGCACCTGGGTCTGGGGCGAGGCGCGCAACGCCCGCGGCGAACGCCGCACGGCGCGCCTGGAGACGGCCAACGTGTACGACCTGACCCTGCACGGCGTGCTCCTGGCAGTGCGCCACCTGCTGGACTACCAGGGTCCCGGCGGCTATTTCACGCCATCGCGGTTGCTCGGCGCGCGCTGCGTCGAATCGTTGCCCGGCTCCGGACGAATCACCGTCATCGGCTGATCAGCCTGACACCCGCACCAAGCCGTCGCCGGCGCGGGCGAGCAGGTGCTCGGTGAGCGACGCGAGCAGTTCGCCGCCGTTGCGCCAGTAGTGCCAGTACAACGGTACGTCGATGACCTGGCCGGGCAGCAGCTCGACCAGTTCACCGCGCGCCAGCTCGCCTTGCACCTGGCGCTCCGGCACCAGGCCCCAGCCGAGACCGCCGGCGGTGAGGCGGACGAAACCTTCCGAGGACGGGCAGAGGTGGTGGATGAAACCGCCCTCGACGCCGAGGTCCTTGAGAAAGCGGTGTTGCAGCAGGTCGTCCGGGCCGAACACGATCGCCGGCACGCCGGCCAGGGCGGCCGCCTCGACCCCGCGGGGAAAGTGCCGGGCAATGAAATCCGGGCTGGCCAGGCCGCGATAACGCATGGCTCCGAGCAGCAGCGAACGCGCGCCGGCCACCGGCCGCGCGCTACCGCAGACGCAGCCCGCCACTTCGCCCGCGCGCATGCGCTTGAGCCCGACCTCCTGGTCCTCCACCACAAGGTCCAGCAGCACCCGCCGCTCGGCGCAGAAATCGCCCACCGCGGCGGCCCACCAGGTCGCCAGGCTATCGGCGTTGAGAGCGATGCGCAGGCGTTCCGGGGCACCGCCCTCATCCAGGTTCGGCACCCAGCGCTGCAGGTCGCCCTCCAGCAGCCGCACCTGCTGCACATGGTTGAGCAGGCGGCGCCCGAGATCGGTGGGATGCGGCGGCGTCTCGCGCACCAGGACCGGCTGGCCGACCCGCGCCTCGAGCAGCTTGATCCGCTGCGATACCGCCGACTGCGACAGCCCCAGCGCCTGTGCGGCGCGCTCGAAACCGCCCTGCTCCACCACTGCGGCCAGCGCGGCGAGCAACTTGTAGTCGAACAAAATCAGTTTTCCTAATGAGAGATCAGCAGGATTCGTTTTCCTTATAAACCGCCCGCGGCCACACTCGCCAGCACTTTTCCGATCCACCCGACGCGGACCGACCATGGCTGGCGAAACCTCGCTGCGCACCCTGCTGCGCACGCTCACTCCCGAACTCAATCCCGGCGACTATGTGTTCTGTACCTGCGCCGCTGGCGCGCTGCCGAACGGCGCCGAGCCGCTCGCCAGCTTCCGCGAGCGCGAGGGCCTGACCCTGGTGCTCGAACGCCGGCAGGCCGAACGCCTGGGCCTGCCCTACGAATACGTGGCGGCCTGGATCACCCTGACGGTGCACTCCTCGTTGGCGGCGGTGGGCCTGACCGCCGCCTTCGCCACGGCGCTGGCCGAAGCCGGGATCAGTTGCAACGTGATGGCCGGCTATTTCCACGACCACCTGTTCGTCGCCCGCGACGAGGGCCGGCGCGCCCTCGCCGTGCTCCAGCGGCTGGCGGCGGAGGCACACTGACATGTGGCAGAGCTATCTCAACGGCATCCTGGTGGCTGCCGGCCTGATCATCGCCATCGGCGCGCAGAATGCCTTCGTCCTCGCGCAGAGCCTGCGCCGCGAGCATCACCTCTCGGTAGCCGCGCTCTGCGTGTTCTGCGACGCGGTGCTGGTCAGCCTCGGCGTGTTCGGCCTGGCCAAGCTGCTGCTGGAAAACCCGACGCTGCTGGCCATCGCCCGCTGGGGCGGGATCGCCTTCCTGACCTGGTACGGGCTCAAGGCGCTGCTTCGCGCGTTGCGCCCGGACGCCCTCGGCAACGCCGCGGAAACCGGGCCACGCTCGCGCAAGGCGGTGCTTCTGGCGGCACTGGCGGTCACCCTGCTCAACCCCCACGTCTATCTCGATACCGTACTTCTTATCGGTTCGCTCGGCGCCCAGCAGGCCGCGCCGGGCGCCTATGCCCTCGGCGCGGCCAGCGCCTCGCTGATGTGGTTCTTCGCCCTCGCCCTCGGCGCGGCATGGCTGGCCCCCTGGCTGGCGCGCCCGGCCACCTGGCGCCTGCTCGACCTGATGGTGGCGGCCATGATGCTGGGCATGGCCGCGCAACTGCTGTTCCGGGGATAACGCGGTTTCTGTCTTCCCGAGCGAACCCTCGCGCCGCCAGGCAGTCCAGAGAGAATGTGGCGGTGTTCGCCGGCGAGCTTGCAGAAGCCCGTCGCAGCGCGCCGCCGCCGGCCTTTGCCCCTACAGTTGCTGCGTGGATATGCCCCGACACGGGTGCTATGATCCGGAGTTCGCGGCACTGGGAGCCTAGGCTCCGAGTCGCACCCGGCGCCCTTTCCGGAGCGCTCCGCCGAACGTCCCCCCCGGGGATCCAGGACGGGCTCCCGGACAGGCATCGGACCGGCCCCGTGAACCGGTCGCGCGCTAGCCGCGCCAGTCCTGACCTGAGGAAGAATAGGAGAGACACCATGGCTTTCGAATTGCCGCCGCTGCCTTACGAAAAGAACGCCCTTGAGCCGCACATTTCCGCAGAAACCCTGGAGTACCACCACGACAAGCACCACAACACCTACGTGGTGAACCTGAACAACCTGATCCCGGGCACCGAGTTCGAAGGCAAGAGCCTCGAAGAGATCGTCAAGAGCTCCTCCGGCGGCATCTTCAACAACGCCGCCCAGGTGTGGAACCACACCTTCTACTGGAACTGCCTGAGCCCGAACGGCGGTGGCCAGCCCACCGGCGCCCTGGCCGACGCCATCAACGCCGCCTTCGGCTCCTTCGACAAGTTCAAGGAAGAGTTCACCAAGACTTCCGTCGGCACCTTCGGTTCCGGCTGGGGCTGGCTGGTGAAGAAGGCCGACGGCTCCCTGGCCCTGGCCAGCACCATCGGTGCCGGCAACCCGCTGACCAGCGGCGACACCCCGCTGCTGACCTGCGACGTCTGGGAACACGCCTACTACATCGACTACCGCAACCTGCGTCCGAAGTACGTCGAGGCGTTCTGGAACCTGGTCAACTGGGACTTCGTAGCGAAGAATTTCGCTGCCTGAGTCTGATCAGAACCACGAAAAAGCCCGGCATTCGCCGGGCTTTTTCGTTTTAATCTGCGGTCCAGGAGCCATCGTCTACCCTCAGGAACTGGTAGACCTTCGCTCGTGATAGCCTCTTGAGGTAAACAAGCTCTTCCTACCGGCTTGTCTTTCGCCCTGGCGACGAACAAGGAAGGCCCCTTGAAACTGGACTCCCGACACAGCCTCTCGCTCAAGCTGCTGCGTGTCGTGCTACTGGCGGCGCTAGCCGTTGGCGTAGTGCTCAGTTGCGCGCAGATCGTCTTCGACGCCTACAAGGCCAAGCAGGCGGTGAGCAGCGACGCCCAACGCATCCTCGCGATGGTCCGCGACCCTTCCACCCAGGCGGTCTACAGCCTCGACCGGGAAATGGCGATGCAGGTCCTCGAAGGCCTGTTCCAGCACGAGGCGGTGCGCCAGGCGAGCATCGGCCATCCCGGCGAGCCAATGCTGGCGGAGAAATCCAGGCCGCTGCTGGACCTGCCGACGCGCTGGCTGACCGACCCGATCCTCGGCCAGGAACGCACCTTCAGCATTCGACTGATCGGCCGCCCGCCCTATAGCGAATACTACGGCGACCTGAAGATCACCCTGGACACCGCGCCCTACGGCGAGAACTTCGTCACCACTTCGGAAATCATCTTCATCTCCGGCATTCTCCGCGCCCTGGCCATGGGCCTGGTGCTGTTCCTGGTCTACCACTGGATGCTGACCAAGCCGCTGTCGAAGATCATCGAGCACCTGGTCAGCATCAATCCCGACCGCCCCAGCCAGCACCAGTTGCCGCTGCTCAAGGGGCACGAACGCAACGAGCTGGGGCTCTGGGTGACCACCGCCAACCAGTTGCTCGCCTCGATCGAAAGCAACAGCCACCTGCGCCGCGAGGCCGAGGACAACCTGCTGCGCATTTCCCAGTACGACTTCCTCACCGGCCTGCCGAACCGCCAGTTGCTGCAGCAGCAACTCGACCAGATCCTCGACGGCGCCGGCCGCCAGCAGCGCCGGGTGGCAGTGCTGTGCCTGGGCCTCGACGATTTCAAGGGGATCAACGAGCAGTACACCTACCAGCTCGGCGACCAGCTGCTGATCGCCCTCGCCGACCGCCTGCGCGGGCACAGCGCGCGGCTCGGTTCGCTGGCGCGCCTGGGCGGCGACCAGTTCGCCCTGGTCCAGGCCGACATCGAGCAACCCTACGAGGCGGCCGAACTGGCGCAGAGCATCCTCGACGGCCTGGAAGCGCCGTTCGAGATCGACCAGCACGAGGTGCGCCTGCGCGCCACCATCGGTATCACCCTGTTCCCCGAGGACGGCGAGACCACGGAGAAACTGCTGCAGAAGGCCGAGCAGACCATGACCCTGGCCAAGACCCGCTCGCGCAACCGCTACCAGTTCTACATCGCCAGCGTGGACAGCGAGATGCGTCGCCGCCGGGAACTGGAAAAGGACCTGCGCGACGCCCTGCAGCGCCACGAGCTGCACCTCGTCTACCAGCCGCAGGTGGACTACCGCGACCACCGCGTGGTCGGCGTCGAGGCGCTGCTGCGCTGGCAACATCCGTTGCACGGCTTCGTCCCGCCGGACCTGTTCATCCCGCTGGCGGAACAGAACGGCAGCATCTTCAGCATCGGCGAGTGGGTGCTCGACCAGGCCTGCCGGCAGTTGCGCGAATGGCACGACCAGGGCTTCGACGACCTGCGCATGGCGGTCAATCTTTCCACCGTGCAGCTCCACCACAACGCCCTGCCACGGGTGGTCAGCAACCTGCTGCAGGTCTACCGCCTGCCGGCGCGCAGCCTGGAGCTGGAAGTCACCGAGACCGGCCTGATGGAGGACATCTCCACTGCCGCCCAGCACCTCCTCAGCCTGCGCCGCGCCGGCGCGCTGATCGCCATCGACGATTTCGGCACCGGCTATTCCTCGCTGAGCTACCTGAAGAGCCTGCCGCTGGACAAGATCAAGATCGACAAGAGTTTCGTCCAGGACCTGCTGCAGGACGAGGACGACGCGACCATCGTTCGCGCCATCATCCAGCTCGGCAAGAGCCTGGGCATGCAGGTGATCGCCGAGGGCGTGGAAACCGCCGAGCAGGAGGCGTACATCATCGCCGAAGGTTGCAACGAAGGTCAGGGCTACCTGTACAGCAAGCCGCTGCCGGCCAGGGAACTGACCCAGTACCTCAAGCAGGCGCGACGCCTGAGCCAGGCCACCAGCAGCGAACGGCCCTGATCAGAACAGGCGGCTGAACAGCCAGCCCGCCAATAGCGCGCTGCCCAGGCAGAGCAACGCGGCCCCCGCCGCCTGGCGGCGCAGTTGCACGGCGAGATCGTCCTCGCCCTGGCTGGAGAGAATGAAGGGATGCGCCTCCCCCGGCTTGCCGAGCCGGTGGCGGGTCGGCGCGGCGCTGCTTGCCCGATGCCGATCCTCGGCCTCCAGCCGTGCCGCCAGGCGCACCCGGTTCCATTCGCGCTCGTCCAGCTCGCCGTTGCCGTCGCTGTCGAAGCGCGCCAGCAGGCCGTGGAAATCGCCCTTCCATTCACGGATCACCGCACCCTGCGCCCGTTCGGCATCGAGTCCCTGGCGACCGCCACCGCTGCTGCGGAATTCGCCCAGCGCATAGAGCGGCTCGCCGGCATGCAGGCGCTCCTCGGTGTAGCGGTAGAGCCGCTCTCCGCCGACCAGGGTGCCGAAGCTCTCCAGCAGTCGCAGGGTATCGATCGGTGCTTCGCGAAAAGCCTCCCAGCGCTGCAGGGTCAAGGGTCGCACCTCGGCGCCGCGTGGGTCGACCAGGCAGGCATCGGTGGCATCGCGCAAGCCGAATGGCGACTCGCTGGCACCTTTGTCGACGGTGCGCCAGGCCTTCTCGCGGCCACTGCGCTTTTCCTCGACTTCGATGCGGTAGCGCCACCACAGGCACGGCTTGCCGGTCAAGGGAGCCTGCAGCGGGCCTTCCGGGCCCTCCTCGAGCACCCCGTAGAGTTCGACGAAACCCTGCGCCGCCGAACGGATCCGCGAGGTCGGTACGTCGCCGAGCAGGCGCGCCCGGGCAAGGCGGTGCACGAACTGCCAGCCGGCCCAGGCGCAGAGCCCCAGGCTGGCGGCGATGAACAGCCAGCGCAGGTCGAAGTCCATCTCAGCCGAACAGGGCCTTGAGATCGACGTCGGCCTTCTCCGCCTCGCTGAACTGCAACAGCTCGGCGGCCTTGAAGCCAGCGACACGAGCGATCAGCAGGTCGGGAAATTGCTCGATGCGCACGTTGTTCAGGTTCACCGCCTCGTTGTACAGCTCGCGGCGATCGGCGATCCCGTTCTCCAGGCCGCTGATGCGCTGGGAAAGGAACTGGAAACTTTCGTTGGCCTTGAGCTGCGGGTAGTTCTCGGCCAGCGCGAAGAGCTGCCCCAGGCCGGCGCGCAGGCCGCTCTCGGCCTTGCCCAGGGCATTCACGTCGGCGCGCTCGCGGGCGCTGGCGACGGCGTTGCGGGCGGCGATGACCCGCTCCAGGGTGGCGCGCTCGTGCTGCATGTATTGCTTGCAGGCCTCGACCAGCTTCGGCAACTCGTCATGGCGCTGCTTGAGGAGCACGTCGATGTTGGCCCAGGCCTTGCCCACGGCGTGCTTCAGCCGTACCAGGCCGTTGTAGAGCACCACCGCGTAGCCGGCGAGCAGCAGCAGGACAACCCAGAAAGCGATAGCGGTCAGACTCATGGACGGAGCTCCGGACGAAGATACTGGCATTCTAGCTGCGCCCGACATGTCCAGGCACGACGGCGATCACGCTGCGCCCTTTTCAAAAATGCAAATCTTTCGCATTATGTGGCGGTTTTTTAACGCCCTCGCGGGTGTTTCCGACAAGCGCACGCCGCTTCGGCACGCCACCAATAAAGCAAAGGAATCCGCCATGACTCGTATGCCCCTGGCCACCGCCAGTCTGCTGGCCCTCGCCATCTCCCTCGCCGGCTGCGGCGACGACAAGAAAGCCGAAGCGCCCGCAACACCGGCGGCCAGCACGCAGCCCGCCGCGCCCGCCGCCGCCCCGGCCGCCAAGGTCGACGAGGCCGCCGCCAAGGCGGTGATCAAGAACTACGCGGACCTCGCCGAAGCCACCTTCGCCGATGCCCTGAGCACCGCCAAGGACCTGCAGAAAGCCATCGACGCGTTCCTCGCCAAGCCTGACGCGGAGACCCTGAAAGCCGCCAAGGAAGCCTGGTTCGCCGCTCGTACCCCCTACTCCCAGAGCGAAGCCTTCCGCTTCGGCAACGCGATCATCGACGACTGGGAAGGACAGGTTAACGCCTGGCCGCTGGACGAAGGCCTGATCGACTATGTCGCCAAGGACTACCAGCACGCCCTGGGCAACCCCGGCGCCACCGCCAACATCGTCGCCAACACCGAGATCCAGGTCGGCGAAGACAAGATCGACGTCAAGGAAATCACCGGCGAGAAACTGGCCAGCCTGAACGAGCTGGGCGGTTCCGAAGCCAACGTCGCCACCGGCTACCACGCCATCGAGTTCCTCCTCTGGGGCCAGGACCTGAACGGCACCGGTCCCGGCGCCGGCAATCGTCCGGCCACCGACTATGCCCAGGGCAAGGACTGCACCGGCGGCCATTGCGACCGTCGCGCCGCCTACCTGAAGGCCGTCACCGACCTGCTGGTCAGCGACCTCGAATACATGGCCGGACAGTGGAAAGCCGGCGTCGCCGACAACTACCGCGCCAAGCTGGAGGCCGAACCGGTGGATACCGGCCTGCGCAAGATGTTCTTCGGCATGGGCAGCCTGTCCCTCGGCGAACTGGCCGGCGAGCGCATGAAGGTCGCGCTGGAGGCCAACTCCACCGAAGACGAGCACGACTGCTTCAGCGACGACACCCACCACACCCTGTTCTTCAACGGCAAGAGCATCCGCAACATCTACCTCGGCGAGTACAAGCGCATCGACGGCAGCGTGGTCAAGGGCCCGAGCCTGGCCGACCTGGTCGCCAAGGCCGACGCCGCCGCCAACGACACCCTGAAGGCCGACCTGGCCGACACCGAGGCCAAGCTGCAGGCCATCGTCGACAGCGCCGAGAAGGATGGCGTGCACTTCGACCAGATGATCGCTCCGGACAACAAGGACGGCCAGCAGAAGATCCGCGACGCCATCGCCGCCCTGGTCAAGCAGACCGGCGCCATCGAGCAGGCCGCGGGCAAGCTGGGTATCCAGGACCTGAAGCCGGACAACGCCGACCACGAGTTCTGATTCCTTCCTGCGCCAACAGCGTGCGGCCCATGGCCGCACGCTGCGTTTCAGGGCCTCGAAAGCGGACTTCGCGGGCCTTTACAAACGCAAATCCCTCTTATTTTGATTAGCTCCAACTGGTAAGCTTGCGGGCTGTTTCTACGCAGTCCGGGATGTTCGCCGATGTCGTTGCCGTCACCTTCCATGCCGCTCGCCTGTCTCCTGACGGCGCTCCTTCTGGGCGGATGCGGCGCCGACGACGAACCGCTGCGCGCCGAGCCCGGCGAACACCTGTCCGGGGGCGCGACCACGGTGCTGCAAAGCGACCGCAACGCCTTCTCCCTGCCCTCCGCCAACCTCGCCCCGAGCCGGCGCCTGGACTTCAGCGTGGGCAACAGTTTCTTCCGCAACCCCTGGGTCATCGCCCCTTCCTCCACCACCGCGCGCGACGGTCTGGGACCGCTGTTCAATACCAACGCCTGCCAGAACTGCCATGTGAAGGACGGCCGCGGCCACCCGCCGGGAGCGGACGCGGTCAGCGCGGTGTCGATGCTGGTACGCCTGTCGATCCCGGCCGGCCCTGCGGACGGCAAGACCCTGTTGCACCAGGGGGTGATTCCCGAGCCGACCTACGGCGGCCAGTTGCAGGACGTCGGCATTCCCGGCGTCGCCCCGGAAGGCAAGGTGCGGGTGGACTACGAGCCGCTGAAGGTGAGGTTCGAGGACGGCACCGAGGTCGAACTGCGCAAGCCGATCCTGCGTATCAGCCAGCTCGGCTATGGGCCGATGCATCCGCAGACGATGTTTTCCGCCCGCGTCGCCCCGCCGATGATCGGGCTCGGCCTGCTCGAGGCGATTCCCGAAGAGGCGATCCTGGCCAATGCCGATCCGGACGACCGCAACGGCGACGGTATCCGCGGGCGCGCCAACCAGGTCTGGGATGCAGCGCGGCAGCGCACCGCGCTCGGCCGCTTCGGCTGGAAGGCCGGCCAGCCGGATATCCCGCAGCAGAACGCGCACGCCTTCGCCAACGACATGGGCCTGACCAGCAGCCTGCTGCCCCACGACGACTGCAGCGCCGCCCAGGTCGAGTGCCGCCGGGCGCCCGACGGCGGCGAGCCGGAAGTCAGCGACAACATCTTCGCCCAGGTGCTGTTCTACAGCCGCAACCTGGCGGTCCCGGCGCGGCGCAAGGTGGACGACCCGCAGGTGCTGGCCGGCAAGCGCCTGTTCGCCCAGGCCAACTGCGTGGCCTGCCACGTTCCCGCCTTCACTACCGGTTCCGACGCCAGCGAGCCGGAGCTGGCCAACCAGCGGATTCGTCCCTATTCCGACCTGTTGCTGCATGACATGGGCGACGGCTTGGCGGACAATCGCCCGGAATTTCTCGCCAGCGGGCGGGACTGGCGAACCCCGCCGCTATGGGGCATCGGCCTGACCGAAACGGTCAACGGCCACACCCAGTTCCTCCACGACGGGCGCGCCCGCAATCTGCTGGAGGCGATCCTCTGGCACGGCGGCGAAGCCGAAGCGGCCAAGCGGCACGTACTCGGCTTCGACGCCGACCAGCGCAGCGCCCTGCTGGCCTTCCTGAATTCACTCTGAGGAGCCCACATGTTCCGCCCACGACTGCTCTTGACCAGCCTCGCCATCGCCCTCGGCGCCTGCTCGCCGCAAGACCCGCAGGCCGTCACCAGTGCCGCCCTGGCGCAACAGGTGATCCTGCCGACCTACAGCCGCTGGGTGGAGGCCGACCAGGCCCTGGCCAGCAGCGCCCTGGCCTACTGCCAGGGCAAGGAAGACCTGGCCAAGGCCCGCGACGCGTTCCACGCCGCGCAGAAGGCCTGGGCCGAGCTGCAACCGCTGCTGATCGGCCCGCTGGCCGAGGGCAACCGCGCCTGGCAGGTGCAGTTCTGGCCGGACAAGAAGGACCTGGTCGGGCGCCAGGTCGAACAGTTGCTGAAGAACAACCCGCAGGTCGACGCCGCGGCCCTGGCCAAGGCCAGCGTGGTGGTGCAGGGGCTCTCCGCCTACGAATACATCCTCTTCGACAGCAAGATCGACCTCGCCGACGCCGCCACCAAGGCCCGCTATTGCCCGTTGCTGGAAGCCATCGGCACCCACCAGCAGCAACTGGCCCAGGACATCCTGGCGCGCTGGAAGAACGACGGCGGCATGCTCACCCAGATGAGCAAGTTCCCCAACGACCGCTACGCCGACGCCCACGAGGCGATCGCCGAGCTGCTGCGGGTCCAGGTCACCGCCCTGGACATGCTGAAGAAGAAACTCGGTACTCCGCTGGGCCGGCAGAGCAAGGGCATTCCCCAGCCCTACCAGGCCGAGGCCTGGCGCAGCAACGCCTCGCTGGCCAGCCTGGACGCCAGCCTGAGCGGCGCCCAGGCGCTCTGGGAAGGTATCGACGGCAAGGGCCTGAAGACCCTGCTGCCGGCCGAACAGAAGGACCTGGCCGGCAAGATCGACGCCGCCTACGCCGACAGCCACGCGAAGCTGGCGGCGCTGGAACAGAAACCGCTCTCCGAACTGCTCGCCAGCGAAGACGGGCGCAACCAGCTCAACGCCCTCTATGACAGCCTGAACGTGGTCCACCGCCTGCACGAAGGCGATCTGGCCCGCGCCCTCGGCGTGCAACTGGGCTTCAACGCCAACGATGGCGACTGAGGTCGGCACCATGCTGCGACGTCATGTGATCGGCCTGGGCAGCCTGCTGCTCGGCGCCTTGTCCTTCGGCGGCTGGAGCTTCAGCCGCCTGGGTAGCCAACCGCTGGTGCTATCGGCGCGCGACGACGCCGATGGCCAGCATTACGCGGTGGGCTACCGCCTGGACGGCAAGTGCCAGTTCGCCACCCGCGTGGCCCAGCGCTGCCACGACATCGTCCAGCACCCGAGCCTGCCGCTGGCGCTGTTCGTCGCCCGCCGGCCAGGCACCGAAAGCTACCTGATCGACCTGAACGACGGTCGCCTGCTGCAGACCCTGGTCTCGCAGAAAGACCGCCACTTCTACGGCCACGGCGTGTTCCACCAGAGCGGCGAGTGGCTCTACGCCACCGAGAACGACACTACCGATCCCGGTCGCGGCGTGCTCGGCGTCTACCGTTTCGACGGCGAGCGACTGCAGCACAGCGGCGAGATCTCCACCCACGGCCTCGGGCCGCACCAGGTTTCCTGGATGCCCGACGGCGAGACCCTGGTAGTGGCCAATGGCGGCATTCGCACCGAGGCGGAAAGCCGGGTCGAGATGAACCTCGACGCCATGGAGCCCAGCCTGGTGCTGATGCGCCGCGACGGCAACCTGCTGTCCAAGGAAACCCTGGCGCAGCAGATGAACAGCGTCCGCCACCTGGCGATCGGTCGCGACGGCACCATCGTCGCCGGCCAGCAGTTCATGGGCGATGCCCACGAACATGCCGACCTGCTGGCGATCAAGCGCCCCGGCCGTCCCTTCGAAGCCTTCCCGGTGGCCGAGGAGCAGCGCCTGGCGATGGCCCAGTACACCGCCAGCGTGGCGATCCACGACGACCTGCGCCTGGTGGCCCTGACCGCCCCGCGCGGCAACCGTTTCTTCATCTGGGACCTGGACAGCGGTGCCGTACGCCTCGACGCGCCGTTGCCGGACTGCGCCGGCGTGGGCGCGGTGAAGAACGGCTTCGTCGTCACGTCCGGACAGGGCCGTTGCCGCTTCTACGACTGCCAGGGCGAGCGCATCGCCGCGCAACCGCTGGAGCTGCCTGCCGGCCTCTGGGACAACCACCTGCACCTGGCCTGAGAGCACGGCATCAACCTCTCGCCATACCGGTCCGCGAAAGTCGGAAGCGACCTGCAACACGCTTGAAATCTTTCGCCAATCCTGTGCTTTGACAAGCCCTGAAAGCTGCACGTAATGTGTCGGATTCGCCCCGAAACGGGGCGCTCTCGGCATACCAGGGACCAGGATTATGTTGCTCCGCCGCATGTTGATCATGCTCGCCGCGGTGATCGCCGTGGTGGCGATTCTCGCCGGCTACAAGGTCTACTCCATCCGTCAGCAGATCGCCCTTTTCAGCGCACCGAAACCGCCGATCAGCGTGACCGCCAGCCTGGCCGAAAAGCGTCCCTGGCAGAGCCGCCTGCCAGCCATCGGCAGCCTCAAGGCATTCCAGGGCGTGACCCTCACCGCCGAAGTCTCCGGCACGGTACGCGACGTACTGTTCCTTTCCGGCGACCAGGTGAAGCTGGACCAACCGCTGATCCAGTTGGAAAGCGACGTCGAGGAAGCCACCCTGCGCACTGCCGAGGCCGATCTCGGCCTGGCCAGGGCCGAGTACCAGCGCGGCCGCGAACTGATCGGCAGCAAGGCCATCTCGAAAAGCGAATTCGATCGTCTCGCCGCGCAGTGGGCCAAGACCAGCGCCACCGTCGCCGAGCTGAAGGCGGCGCTGGCGAAGAAGCGCGTGCTCGCGCCCTTCGCCGGGACCATCGGCATCCGCCAGGTGGACGTCGGCGACTACGTCTCGCCCGGGACGCCGATCGCCACCTTGCAGGACCTTTCCACCCTGCTCCTGGATTTCCACCTGCCCGAGCAGGACTTCCCCCTGCTCAGCCGCGGCCAGCTGGTGAAGGTCCGGGTCGCCGCCTACCCCGGCCAGGTGTTCGACGCCGAGATCGCCGCCATCAACCCCAAGGTCGACAACGAGACCCGCAACCTGCAGGTCCGCGCTGCCCTGGAGAACCCGGACGGCAAGCTGCTGCCGGGCATGTTCGCCAACCTCGAGGTGATGTTGCCTGGCGAGGAACAACGCGTCGTGGTGCCGGAGACGGCGATCACCTTCACCCTCTACGGCGACTCGATCTACGTCGTCGGGCAGAAGAAGGACGAGCAGGGCCAGGTGTCGAAGGATGACAAGGGCCAGCCGCAACGGGTCGTCGAGCGCCGCTTCGTCAGGATCGGCGAACGCCGCGAAGGCCTGGCGGTGGTGCTCGAAGGCCTGGAGGGCGGCGAGCAGGTAGTGACTTCCGGGCAACTGAAGCTCGACAACGGCGCCGCGGTGGCCATCGTCGCCGAGCGGGACCTCCAGCAAGAGCACTGAGTCGCGCGCCTTCCCACTCCGTGGCGGAAGGCTTGCCAAGGGACTGAAACATGGCTTTTACCGATCCGTTCATCCGTCGTCCGGTCCTGGCGAGCGTGGTCAGCCTGCTGATCGTCCTGCTCGGCATGCAGGCCTTCAGCAAGCTGGTGATCCGCGAGTATCCGCAAATGGAGAACGCGCTGATCACGGTGACCACGCTCTACGCCGGCGCCAACGCGGAAACCATCCAGGGCTACATCACCCAGCCGCTGCAGCAGAGCCTGGCCAGCGCCGAAGGCATCGACTACATGACCTCGGTGAGCCGGCAGAACTATTCGACCATCTCCATCTACGCGCGGATCGGCGCCAATACCGATCGCCTGGTCACCGAGCTGCTGGCCAAGTCCAACGAAGTGAAGAGCCAGCTGCCGCCGGACGCCGAGGACCCGGTGCTGCAGAAGGAGGCCGCGGACGCCTCGGCGCTGATGTACATCAGCTTCTACAGCGAGCAGATGAACAACCCGCAGATCACCGACTACCTGTCGCGGGTGATCCAGCCCAAGCTGGCGACCCTGCCCGGTATCGCCGAGGCGGAGATCCTCGGCAACCAGGTGTTCGCCATGCGCCTGTGGCTGGACCCGGTGAAGATGGCCGCGTTCGGCGTCACCGCCGGCGAGATCAACCAGGCGGTGCAGCAGTACAACTTCCTCGCCGCCGCCGGCGAGGTGAAGGGCCAGTTGGTGGTCACCAGCGTCAATGCTTCCACCGACCTCAAGTCGCCCCAGGCCTTCGCCGCCATCCCGGTGAAGACCGACGGCGACCGCCGGGTGCTGATGGGTGATGTCGCACGGGTCGAGCTGGGCGCCGCCAGCTACGACGCGATCAGTTCGTTCAATGGGATTCCCTCGGTCTACATCGGCATCAAGGGCACGCCCAGCGCCAACCCGCTGGACGTGATCAAGGAAGTGCGGGCGAAGATGCCCGAACTGGAAGAGCAATTGCCGCCCAACCTCAAGGTGTCCATCGCCTACGACGCCACGCGCTTCATTCAGGCCTCCATCGATGAAGTGGTGAAGACCCTCGGCGAGGCGGTGCTGATCGTCATCGTGGTGGTGTTCCTGTTCCTCGGCGCGTTCCGTTCGGTACTGATCCCGGTGGTGACCATTCCGCTGTCGATGATCGGCGTATTGTTCTTCATGCAGGCCATGGGCTACTCGATCAACCTGCTGACCCTGCTGGCGATGGTCCTGGCCATCGGGCTGGTGGTGGACGACGCGATCGTGGTGGTGGAAAACATCCACCGCCACATCGAGGAGGGCAAGCCGCCCTTCGAGGCCGCCCTGGAGGGCGCGCGGGAGATCGCCGTACCGGTGGTCAGCATGACCATCACCCTCGCCGCGGTCTACGCGCCGATCGGTTTCCTCACCGGCCTCACCGGCGCCCTGTTCAAGGAGTTCGCCTTCACCCTGGCCGGCGCGGTGATCATTTCCGGGATCGTCGCCCTGACCCTGTCGCCGATGATGTGCTCGCGCCTGCTGCGCCACGAGGAGAATCCCTCGGGCCTGGCGCATCGCCTCGACCTGATCTTCGAGGGCCTGAAGCAACGCTACCAGCGCGCCCTCCACGGCACCCTGGACACCCGTCCGGTGGTCCTGGTGTTCGCCGTGCTGGTACTGGCGCTGATCCCGGTACTGCTGATGTTCACCAAGAAGGAGCTGGCGCCGGAAGAGGACCAGGGCATCGTGTTCCT
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/sim1_galaxy.fasta
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/sim1_galaxy.fasta	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,12526 @@
+>NODE_19_length_33054_cov_76.4496_ID_37
+GGCCTGTCCGGCTGACGTGCTGGCTGCGCGTGCTGAGTCCGCAGCATCAGCCGCATGGGT
+TGCCGCCTCACGGGCTGATGTGCTGGCATCACTGGCTGACTTCTTCGCGGCTGCCGTGTT
+CTGTGCCACCGCGGACGCGTTACGCGCCACCTCTTCCACCATCAGTTCAAAACGGCGCAG
+TGCCTCCGGACGGGCATCATCCTCCGTCATGGCACCGAGAAAATCATTCAGCGTACCGGG
+TTGAGAATCTTCATACACGGTAATGGTCCCGGCATGTGACGGCGGGAATCCTTCCACCAA
+CAGAATAACGCTGTACTGACCGTACTCAACGTCCATGCTGTAACGCCCGGCTTCATCCGG
+ATTTTCTGAGGCCAGCGTGTTCACCACCACCGTGGTGCTGTTACGTTTTGCTTTCAGCTG
+GATTGTGCAGTTCTGTACCGGTTTTCCTGTGCCGTCTTTCAGTACACCTGAAATCTTTAC
+TGCCATATTCACCCCACAAAAAAGCCCGCCTGAACCGGCGGGCTGTCATAACACTGTGTT
+ACCTGGCTAATCAGAACTTATAACCGACACCCACGATGAAACCGTCAGTGCGCCAGTCGC
+CACTGCCGGGGCCTTCATAAGCAATATCAATGGCCACGGATTCGGTCGGGTTAAACTGCA
+CGCCAGCTCCCCACGCCAGAGACGTGTTGCTGTGGCGACCGTCATCACTTCCGGTCAGCA
+CGTCGTGCGTTTTCCCCTTGGGAAGGTGCGAACAAGTTCCTGATATGAGATCATCATATT
+CATCCGGAGCGCATCCCAGAGGGACATCATGAGCCATCAACTCACCTTCGCCGATAGTGA
+ATTCAGCACTAAGCGCCGTCAGACCCGAAAAGAGATTTTCCTCTCCCGCATGGAGCAGAT
+TCTGCCATGGCAGAATATGACCGCTGTCATCGAGCCGTTTTATCCCAAGGCGGGCAATGG
+CCGACGGCCCTATCCGCTGGAGACCATGCTGCGTATTCACTGCATGCAGCATTGGTACAA
+CCTGAGCGACGGTGCCATGGAAGATGCCCTGTACGAAATCGCCTCCATGCGCCTGTTTGC
+CCGATTATCCCTGGATAGCGCCCTGCCGGATCGCACCACCATCATGAATTTCCGCCACCT
+GCTCGAGCAGCATCAACTGGCCCGTCAATTGTTCAAGACCATCAATCGCTGGCTGGCCGA
+AGCAGGCGTCATGATGACCCAAGGCACTTTGGTGGATGCCACCATCATTGAGGCACCCAG
+CTCTACCAAGAACAAAGAGCAGCAACGCGATCCGGAGATGCATCAGACCAAGAAAGGCAA
+TCAGTGGCACTTTGGCATGAAGGCCCACATTGGTGTCGATGCCAAGAGTGGCCTGACCCA
+CAGCCTGGTCACCACCGCGGCCAACGAGCATGACCTCAATCAGCTGGGTAATCTGCTTCA
+TGGAGAGGAGCAATTTGTCTCAGCCGATGCCGGCTACCAAGGAGCGCCACAGCGCGAGGA
+GCTGGCCGAGGTGGATGTGGACTGGCTGATCGCCGAGCGTCCCGGCAAGGTAAAAACCTT
+GAAGCAGAATCCGCGCAAGAACAAAACGGCCATCAACATCGAATACATGAAAGCCAGCAT
+CCGTGCCAGGGTGGAGCACCCGTTTCGCATCATCAAGCGGCAGTTCGGCTTCGTGAAAGC
+CAGATACAAGGGGCTGCTGAAAAACGATAACCAACTGGCGATGTTATTCACCCTGGCCAA
+CCTGTTTCGGGTGGACCAAATGATACGTCAGTGGGAGAGATCTCAGTAAAAACCGGAAAT
+AACGCCAGAAATGGTGGAAAAAATAGCCTAAATAGGCTGATTCGATGTGTTTGCGGGAAA
+AAAATCGGCCCAGATCCGCGAAATTTTAATCAGCGAGTCAGCTTGGGAAGAAATGACCTG
+CTTATTCGCACCTTCCCTTGTTGTCAGTTACGCGGAGATAATCCCCGGAGAAAGTCGACA
+CACGGCTGTAAGCCATACCCGCCATCGCATACGCGCTGAACCATTCATTCACGCGCACAG
+ACGGCCCCACCATCACGCTGAACCAGCGGTTACGCACGGAATCTTCATGCCAGCGGGTAT
+CGCTGTAACGGGTAAGCTGGCGATTCTTGTCTCCTGCATAGCTGAATGGCCGCCCTGCTG
+CATTAACACCATAAATGGCGACTGACCAGTGGACAACCCAACAACAATATCCGTCATTTG
+TGCAGGCAACATGCGCATAGCAAAAGCCGTTTGTTTTGCCGACATTCCGGTTTTGCTTAA
+TTGTGATTGAGTAACCTCAAGCTCACTCCGCATAGCACGAAGTTTTCCAGAAAGCTCCTC
+ATACATTTCAGGAGAAAGCATCCCCTTAGCTTTTGCTTCATTGAGCTGTTTCTGTTGTTC
+TACCAGACGATTAAAAGCAGTTCCGACAGGATCAAGTTGAGCAATCAGACGTTGCAAAGC
+AACAACCTGTTCATCATGCGCTTTTGCTGCTTCTCGCTCTGCCTGAGCCTCTCCGGTAAG
+CTCTCGCCGTGTTTCCTGTATTTTTCGGCTATAATTCTCAAACTGAGAACCATTTATTTT
+CCCGGATGCAAACGCAGCATTAAGTTCATCATGCTGTTGTTCAAGATTTCTTAGCGCCGC
+AGCCAGAGGGTCGATCTTGTCCAGCATTCTTTGAAAGGCCTGAGCCTGCGCTTCCTGCTG
+AGCGGCAGCAAGTTTTCCGGCCTTCTCGGCTTCTCTCTGCGCTTGCGCAACCCCGCTCAA
+TTCCTCTGTGGTTTCATTAAGTTTACGGACAAGAAATTCATATTCTTCTTTATCAATAAG
+CCCTTTATCGAAAAATTTCTTTAATTCAGAATAGCGTCGACCGACAGTATCAATTGCGGC
+ACCAACTGGATCAATAGCTGCTTTTAATTTTGCGAGCGCGTTCTTCTCATCTTCTGTTGC
+CTTAGTCACTTTCCCTGCGCTATTTGCAGCAGTTTCCCCAGCCTGCGTCATTTTGACTAA
+TGAGGAGGTCAGATTGTCAGCATTATTTTTCGCTCCAGTGCTATCAATAATTATTGCGAG
+ACGCGAGGTTTGCTCTGCCATTTATTAAAACTCCTGACAACAAAAAACCCACCGCGAAGT
+GGGTTTCAGGCGACATAATAGTAGATATAGCGATTACGAGGCCACGCAATGCTTTTCTCC
+AGGAGCATCATCGATTTAATTAAAGACACCATCACATCTCTGTAACAGAGTGTACGTAAT
+TAACAACTACACACACTGCTCCTGAAAATACTGGTCATCCAGTGCAAAGATCACTGCTTC
+AAATTCATCGCGCTCAATCAATACCGGATGAGTGGCTAAATATTCATTTATCTCTGTCAG
+AGATAAAGGCAAAGGCACCCCAGCCATTCCAGCATAACGTCGGGCACGGGATATTACCGA
+ATAGGCGTACAACAACTCCTTAAGCACCGGGTCTATTTCTGGTTCCGGTATCGGTGGCAA
+CCTGAGTTTTTCTCGCTTCCATCTTGCCTTTTCCCCCCTTTCTCCCCCGAACTCCGATAA
+CCACCGCTGGGCAGCTATGGCTTTTTTATCGTATCCTGCTTCTGCTGCTCTTTACCCTGG
+GCGATGCTGGCTGCTTCTGCAAGGATCTGCCAGTACAACTCTGGATTCTGCTTAAGCAGC
+GCGATCCCTCGTTCTGCCGTATATTCCAGTGCAACCTCAACACCATTAACCAGTTCACCA
+ACCCCTTTCCAGTCTTTCAGCAGATAACGAGCGGCATTATCAATGAGTAAATCATCAACA
+GAATCCACCTCGGAAACCTTTGAAATATCAAACTCCTTCGTTCCGACGTGCAAACTGGCA
+TCCATTTTCTCAATGTGGCGACGGATTAATGCATTACGGGAGCGATACTGATCGTTATCG
+CTGCTTCTGCTCATCCGTCAGGCCAGACAGAACAATGACCGGAACAGAATCCATTTTGAG
+CATTTCAGCCGCCATAACACGACCGTGACCCGCAATAATTTCGCCCTTTTCGTCAATCAG
+CACCGGATTAGTCCAGCCGAATTGCTTAATACTTTCTACCAGTTGTGCCACCTGCTCAGT
+ACTGTGCGTCCTGGCGTTGTGCGCATACGGTGACAATTCTTGTAATGGGCGATAGACTAT
+CTTTAATTTCTCGCTCATACAGCCTTGCTTTATGAATAAAACGCACCCCAGCAGCCAGTG
+CTACTGGGGACGGAGGTGTTGCTGGTAAAGTTAGGTATTGGATCAATGAGTGAGTCAACA
+TAATATTAAACTCACAATTATAAATCAGCCATATATTAGGAGCGCCAAAAAAAACCTGAA
+AACAATATAATAACAGGATAAATTTCAAGGCGACCAAGAATCATAGCTATGCACATTAAG
+CATTTTGCAATGTCATTAAGCACTCCGAATGACGATGCAGTAGCCCCAAAACCTAATCCC
+ATATTATTAATACATGCAGCCACTGTTGCAAATGATGTAAGAAAATCATATCCCATACCA
+TTTAACACCAGTATAAAAAACACCGTGAAGAGAGTATAAAGAAAAAAGAAACTCCATACA
+GACCTCATTACACGATCTGTAACTATCTTCCCTCCTACATTTACACTCAACAACGCTCTG
+GGATGAGAAAGCTGATTTATCTCGTGTTTGCTTTGTTTGAAAAGTATAAGAAATCGAAGT
+GACTTAATTCCACCACAAGTTGAACCTATACATCCCCCAAAGAAACTTGACAACAGCAAA
+AACACTATCGTGTGCGTGGGCCAACTTGCATAATCCTGCGTAGCTAAACCATTATCAGTG
+AGCATGGAGCTGGCAAGAAAAAACGAATGAATAAAACTTCCATGCAAGTCATACATACCT
+ATATGCCAGACCTGGAAAGAGGTAACAATGATCACCCCTAAGGCTATTAACAGAAAGAAA
+CGAAGTTCAATATCTCTGATTAAAGGTTTTATCGTTTTCCTGCTAATAACAATATACCAA
+AGAGTGAAGTTGAAAGCCGATAGCAGGGAAAAAGAACCAGCCACCAGCTCAACCAAATAG
+TTATTAAAATATCCGATACTCTCGCTATGAGTTGAGAAACCACCAAGCGAAACTGTGGAA
+ATCCCGTGACAAATAGCATCAAACAAAGGCATTCCTGCAAGTCTATAACAGACAATACAA
+GCAATACCTAATAAAGAATAAGTTATCCACAGTGTCCGTGACGTATCGGCCAGGCGGGGA
+GTGAGTTTGTCATCCTTAAATGGCCCCGGCATTTCTGACTGATAAAGCTTTGCACCACCA
+ATACCCAATAATGGCAATACAGCAACCGCCAGAACAATAACTCCTAAACCACCTATAAAA
+TTTAACTGTGACCGATAGTACAAATATGCCCGAGGTAATGAACTAACATCATCAATTACA
+GTTGCTCCTGTTGTTGTTATTCCAGAAACCCCTTCAAACAGAGCATCAATGAACGTTAAA
+TTAAGTTCTGAGTCAATCCATAAAGGGAATGCACTAATAACAGAAAACAAAATCCAAAAC
+ATTACAATTATAATAAACCCATCACGGGTACGTAATTGAATGCCAGATTTCTTAGTTGTA
+TACCACGCTCCGCCACCAATGCAAAAAAATATAACGAAAGTTATAAAGAAAACAAACAGG
+CTTTTTTCTTTATAAAACAATGCTACAACCATTGGTGGCAACATTGAAAGACTATAGAGC
+CAAACCAGGAACCCACACATATGAGTAACAACTCTTACATGAGATGTATTCATATCTAAA
+TATTCTTTCAATTATAACCACCTTGCTGCAATATTATGATTATACTGTATAAAATTTAAC
+TCCTCTTAGATCTTACTTCACTGTTCCTTATGAAACAATCATCAAAATGAATCATATTGT
+AGTTAAGATTTTACTTTAAACACTGCTCGGTTATGTATTGCTGAGCACCTTCAAGTTGGG
+CCTGCATCATTACCAGTCGTTCCCGGAGGGTGAAATAATCCCGTTCAGCGGTGTCTGCCA
+GTCGGGGGGAGGCTGCATTATCCACGCCGGAGGCGGTGGTGGCTTCACGCACTGACTGAC
+AGACTGCTTTGATGTGCAACCGACGACGACCAGCGGCAACATCATCACGCAGAGCATCAT
+TTTCAGCTTTCGCATCAGCTAACTCCTTCGTGTATTTTGCATCGAGCGCAGCAACATCAC
+GCTGACGCATCTGCATCTCAGTAATTGCCGCGTTCGCCAGCTTCAGTTCTCTGGCATTTT
+TGTCGCGCTGTTCTTTGTAGGCGATGGCGTTATCACGGTAATGATTAACACCCCATGACA
+GGCAGACGACGATGCAGATAACCAGAGCGGAGATACCGATGCTGCTTTCGGCTCTGCTGG
+TAAATTATCGCCCGGTATGCAGTAACGAAATTTACCGCCCTGATTTACGCGAATCAGACG
+ACCTTTGCTGATTGCCATTGCCAGCGTTGAAGCCACTTTGCGTGATGTGGTACCAAACAA
+TGTAGCCAGCTCATCAGCCGTTTGTGGTCCTCGTTGTTCAATCGTCGCGGTTAAATCGCA
+CTCTGAGATTTTCGCTACTGTTGCTGTGGTGATTTCTTCCGGCAGTTCTGCCTGCGCTGG
+CTGTTCCTGCTGAACATTGTTATCAGCCACACGCCAGGTGTACGCGCTTTTATCAACAAA
+ACCAGCCTTTTTCAGTTCCCATAGTTCGTTCAGCACTTCTTCACGACTGATATCAAGTCG
+CGCAGCAAGTTCTATGGATGTGGCTTTTCCCATTGCTTTCAGTGCGTCAAAAACAGTCTC
+CATTAAATTTTTCTCCCGGTAAAAATTACTTCGCAATTCCTGGCTGGACGACATTCGGAC
+GCCAGCTCTCCCAGTTAAAATTCACCCATCGCCCGCCGTTCATGGTCATGCGATCCATAA
+TCCGCTCGCCGAGCAATGTTTTCATGGCCTCATAGTTCAGGTTTGTCAGCATCCCCACGC
+TGCGCATCGACGCTGTCCGGCGATCAACAATCTGGTGCAGTACCACCTGCTCGTTTTTCG
+TCTCGCGCTGAATGCCAATTTCATCAAGAACCAGCAGATCCACTTCGCACAGTTCCCGCA
+AAAATTTTTCGCCTGACTGCCCATCGTCATAGCTGGCGTGCAGGGCACTCATAACATCAG
+CCACGGTAACCACAATCACTGTCTGACCGTCTTTCAGCAGGCGATTCCCGATAGCTGCCG
+CTAAGTGGTTCTTCCCGGTACCAGGTTTTCCGCTGAACGCAAAATTTGTACACCCGGTCA
+TCAGTTCATCAGCGATGGATTTCGCCTGACTCAACGCGTATCGCTGCCCTTCGTTCTGCA
+CCTGGTAATTCGAAAACGAGCATTTGCGGTGCAATGGCTGGATGCCAGAGCGATTCAGAA
+TTTTTTCCACCCGCAACTGACGATTCTGACGGTTGATCTCCTCACAACGTTTCTGGCCTT
+CGGAAAGTTGCCACTCGCGCCACTCCGCTACCGTCTTGAATGGCGCGGTTACATGTGACG
+GGGCCAGTCTGCGGATACGTTCAAGAACATCGCCTGTCGCAATATTTTTCATGGTCAGTT
+ACCCCCTGAAGCCTGGCGGGATCGCACTATCCGGTAACGAGACGGTGTTAACCTGTCGGA
+GTAACGTCTCAGGTCGAACACCTTTCGGCGCGAACAAGCCCTGGTATTCATTGGCGATGC
+TGTGTCGAATCACCTGCTCAGGTGAAAAACCCTGCTGGCGGAATTTTTCCAGCTCCCGTA
+TCGCCCCGTTAGCGCCCTGCTCCGTTCGAATCGGTTTTCGCAATGCCTGGCGAAATTCAA
+CCCACTCACGCCAAAGCGAGACAGAAATCCAGTTCGGCAAAGTAATATCCAGAGGGTCAA
+ACTTTTTGACACCTCGATTCCCCCGGGGGGGATTTAGGGGGGGATCTGTTTTTAGATCTT
+TATCTGTATCTTTATTAGTTGCCTTTGTGTTGACATCATGTTCAAACACCACTTCAACAT
+CTGTTTGAACACCTGTTAAATTTCTCTCTTGTTTTGTTTGAACATCTGCTTCCTTTCTGC
+TTCTTCTGGCCTGAACAGATGCTTTTCCTGCGGCTGATTTTTTGGTTAATTTTTCCCTGA
+CTGATGCCAGATCTTCCTCAATCCGAAGATGCACCCATTCCTCGCCGTTATCGCAAAAAA
+ACTCCTGCAAGGATGGTTCAACATCAGCCCATCGCTCGTTAGTCAGACGGGCAATTTTTG
+CCAGCCTGTTTTTAGGTATTGGCTTTCCTGTTTGCCAGTAATTGAACATCAGCAACAAAT
+ACGCACCATGCTCCTCTGCTGACAAATGCATGGTGTCAGCCAGGTAATCAGCTATGTACA
+GTTGCATGTATGGTAATGCGGCCATAATTGCCCCGTATGATGCTGCCCGGTGGCTTAGAA
+TAAGCACAAACAGCATGGAAACTTTTGCTTAATGAACAATGACAGAATCGTCGGAAGAAC
+CGCCGCCGCTGAAATGCGCTTTCCGGTAAACGGCTTGGACTGCATCATCATGCGCATCAA
+TTGCCGTACTTAACGCTTCCTGCGCCGCCAGTAATGCACGGCGTTCCAGGGTATCGAAGA
+TGCAGAGTCGGTGACGCAGCTCGCGCGGAAGGATTGCCAGAATTGCTGGGATCAGCTTCT
+GAATTTTTTCTCTTTGCGTTTTCGTTTCACCTTTCAACCAACGGTGATAGATATTCTGCT
+GATTGTTCCAGTCCTTGCCTGGAACCAGGGGCAATTCGCCGCCCCCCTGGCGCAGATATT
+CTTCAGTAATTGCATTGGCTACCCATGCCTGCCCTTTTTCGGCTGCTAGGGCAAACAACA
+CTGATTCGATGTGCTCATGCTTGATTTTCATGAATCATTTGCCTCTTGATGTTTCAGGTA
+TGATCAAATGAGGATTTGTTACTGTCATTTAGTTGCTTCACTGACATATTCTGCGAACAA
+CATGCCGAACGTCGTAAATATGACCAGTCAATATCAGGACGAAGTTCTTCGCACAGAACC
+TCACCTCTTGTTGCACGTTCAATTGCTGGACATCTCTCGGCAGGCAATTGACGTACCCCT
+TTGATCCATTGATTTACGCTTGGAGGTGATACACCTAAAAGCCTAGCCATTGCTGATTGC
+CCACCGACAACAGCACAAGCTTGCTTGAATGAATAGTTCTCTTTTTTCATCGAATGAACT
+CCAAAAACACACAGAAATATTAGGCGACGCCTAACGCAATTGTCAATAGGCTGTGCCTAA
+TGCAGTAAGGGTAGGGATTGCCTAATGTAATGCGCATAGGAGAATATTAAGCAATGCTTA
+GTGGTAAAGACTTAGGCCGAGCGATAGAGCAGGCCATTAACAAAAAAATCGCATCGGGAT
+CCGTCAAATCAAAGGCGGAGGTCGCACGCCACTTTAAAGTCCAACCACCATCAATTTATG
+ACTGGATTAAGAAAGGCTCTATAAGTAAAGATAAACTTCCAGAATTATGGCGTTTCTTTT
+CTGATGTTGTTGGTCCAGAGCATTGGGGGCTTAACGAATACCCCATACCAACCCCCACCA
+ATTCAGATACAAAAAGTGAACTTTTAGATATAAACAACCTTTATCAAGCAGCCTCTGATG
+AAATAAGAGCGATTGTAGCTTTCCTGTTATCTGGAAATGCTACAGAACCAGATTGGGTTG
+ACCACGATGTTCGCGCCTACATAGCAGCGATGGAAATGAAAGTGGGTAAGTATCTGAAAG
+CTCTTGAATCTGAACGGAAAAGCCAGAACATCACAAAAACTGGAACTTAAACTTATATGG
+TCTGACGGAAAACTCCTGGATTCCGTTATTTAACCCCCCCATCACTTTCTGCTGTCGCCA
+TCACCTATTAGGTTACGCTCAAAACATTAGGCATAGCCTATTGACAATCAATTAGGCATT
+ACCTATAGTTCCAGCATACCACCCACCCCGCCCCACAGAACGCCGGGCAATACTTCGAGT
+TACCAGGCAGTGGTAAGGGGTTAAGTAGCCAGCCCGAGGCGTATGAACATGACGGCGGGA
+TTCAAATTTTGCAGTGCAGCAGTTAGTTCCGCCACCCGGCGTTAAGGGGAGAGATAAGAT
+GGTGCATTACGAAGTAGTTCAGTATTTGATGGATTGTTGCGGTATCACTTACAACCAGGC
+TGTGCAGGCTTTACGCAGCAACGACTGGGATCTCTGGCAGGCAGAAGTCGCTATACGTAG
+CAACAAGATGTGAGATTCGCAAAATGCAAAAAATCGACCTCGGCAACAACGAATCCCTGG
+TGTGCGGCGTGTTCCCCAACCAGGATGGAACGTTCACTGCCATGACGTATACCAAAAGCA
+AAACATTTAAAACCGAAACTGGTGCGCGCCGATGGTTGGAGAAGCACACAGTAAGCTAAC
+GATTAAAACGTCTACTCCTGCTGTTCCAGAATAACTTCATAAAATGGGAGTATTTTTCGG
+TGACGAGATAATAAGAACAGTTTGCGCTATCACTCTGATGTTGAATGATGCCCTTCCGTT
+CTAATTTTTTCATAACCGGGTTACGGCAAGGAGAAGTGATAATAAGATTTCCTGTTTTAA
+GGAAATCTTTAAATACAGCGATTTCTTTCTCAGATAAACGAAGCAATACTCGTTGCTCTG
+GTAGTAATGAATAATGCTTTTGAATATGTGCTCGCAATCTTGAGAAGGAAATGGCGACCA
+CGAAAGAAAAGGCAAAAACGATAATCTGAAAGAGCCAAGGTATTTCAGTATAAGCATTGA
+ATGCGACAGTAAACTCTTTCGGTATCAGCCAGAGAGTGAGACCAAAAATGATAATCGTAT
+ACATAAGTCTTTCGAGTGGCTCGTTAGCAAAAAGTTTCAACAATGGAGTAAATACATCCA
+ACATATCAATAACTCTCAACTGTAAGGGTATTGAAATGTTAACACAAGCTCTCGCTGTAG
+GGGTATAGCCGAGACCACCGAAGCCCGGAGGTGGTGAAATAAAACCGGGCACAACACGAA
+GGCGCATTTCCGATATCCATAAAGAGTCGGTCTTGTCTGTTAAATTTAAATGGTGGGAGT
+GCGCCTCCGGTTGTAAATAACGACATTGCTGTGTGTAGTCCTGGCGGCATCAGTTTTTTT
+CTTGAAGTTCGGCTGATGTCCGCCCTTTTTAAAGTGAATTTTGTGATGCGGTGAATGCGG
+CTAAGCGCACGTGGCACAGTTAAAAGTCATGTTAGTCCTTATTGGTTTGGGTGGGAAAGC
+CGACTGTAATTGTTAACTGGTTGCAGTCACCTGGAGGCACCAGACACCGCATCAACAAAG
+TTCATTTGTAAAAATGGAGATAATTATGATTGCACATCACTTCGGAACTGATGAAATACC
+ACGTCAGTGTGTGACTCCTGGCGATTATGTTCTTCATGAAGGCCGGACATATATTGCCTC
+GGCAAACAATATTAAAAAGCGAAAACTATATATTCGTAACCTGACCACAAAAACATTCAT
+TACTGACCGCATGATTAAAGTCTTCCTCGGTCGTGATGGTTTACCTGTAAAGGCGGAGTC
+ATGGTGATGACTAAGAAAATAAAATGTGCTTACCACCTTTGCAAAAAAGACGTTGAAGAA
+AGCAAAGCTATTGAAAGAATGCTTCACTTCATGCACGGGATTTTATCAAAAGACGAACCG
+AGAAAATATTGCAGTGAAGCTTGTGCCGAAAAAGACCAGATGGCACATGAACTTTAATTA
+ATTGACTATTCGAAACTGAATTTATGCCAGAAATGGCAGGTATTCGCTCAACCTTAATTA
+AGGAGAAAAACATGATTACCAATTATGAAGCCACTGTTGTAACTACCGATGACATTGTTC
+ACGAGGTGAATCTGGAAGGAAAGCGCATTGGCTACGTAATTAAAACAGAAAATAAAGAAA
+CCCCATTCACTGTGGTTGATATCGATGGTCCATCAGGCAACGTAAAAACACTTGATGAAG
+GTGTCAAAAAAATGTGCCTGGTGCATATCGGAAAGAATCTGCCCGCAGAAAAAAAAGCCG
+AATTTCTGGCAACTCTAATTGCAATGAAATTAAAAGGTGAAATCTGAAAGAAATAGCCTG
+CGTATGGCGCAGGCTATGAACAGTGTGTATCCGGCAAGATCATTCACTGAACAAAACGAA
+TTTTAATCTGAGTTGAGGTTAAAAAACAATGAGCACAAAACCACTCTTCCTGTTACGGAA
+AGCGAAAAAATCATCCGGTGAACCTGACGTCGTCCTGTGGGCAAGCAACGATTTTGAATC
+GACCTGTGCCACTCTGGACTACCTGATCGTTAAGTCAGGTAAAAAACTGAGCAGCTATTT
+TAAAGCTGTTGCCACGAATTTTCCTGTCGTTAATGACCTGCCCGCTGAAGGTGAGATCGA
+TTTTACCTGGAGTGAACGCTATCAACTCAGCAAAGACTCCATGACATGGGAACTAAAACC
+GGGAGCAGCACCAGACAACGCTCACTATCAAGGCAATACCAACGTCAACGGCGAAGACAT
+GACTGAGATTGAGGAGAATATGCTACTCCCAATTTCTGGCCAGGAACTGCCCATTCGTTG
+GCTTGCTCAACACGGCAGCGAAAAACCGGTAACGCACGTTTCACGCGACGGACTCCAGGC
+ATTACACATTGCTCGGGCTGAAGAACTACCGGCTGTTACTGCCCTGGCTGTTTCCCACAA
+AACCAGCCTGCTCGACCCGCTGGAAATTCGCGAACTCCACAAACTGGTTCGTGACACTGA
+CAAAGTTTTCCCTAATCCTGGTAATTCAAACCTGGGACTGATAACTGCTTTTTTCGAAGC
+ATACCTGAACGCTGACTACACCGATCGAGGACTGCTGACAAAAGAGTGGATGAAGGGTAA
+TCGTGTTTCACACATCACTCGCACGGCTTCCGGTGCTAATGCTGGCGGCGGAAACCTCAC
+CGATCGCGGCGAAGGTTTCGTACACGATCTGACGTCACTGGCGCGCGACGTAGCCACTGG
+CGTACTGGCCCGTTCAATGGATCTGGACATCTATAACCTTCATCCGGCACACGCTAAACG
+CATTGAGGAAATTATCGCTGAAAATAAACCGCCCTTTTCTGTTTTCCGCGACAAATTCAT
+CACCATGCCTGGCGGGCTGGATTATTCCCGCGCCATCGTGGTTGCGTCCGTAAAAGAAGC
+ACCAATTGGGATCGAGGTCATCCCCGCGCACGTCACTGAATATCTGAACAAAGTACTGAC
+TGAAACCGATCATGCCAACCCTGATCCGGAAATCGTGGATATTGCCTGCGGTCGCTCCTC
+TGCCCCGATGCCGCAGCGAGTAACAGAAGAAGGAAAACAGGATGATGAAGAAAAACCGCA
+ACCATCTGGAACAACGGCAGTTGAACAGGGAGAGGCTGAAACAATGGAACCGGACGCAAC
+TGAACATCATCAGGACACGCAGCCGCTGGATGCTCAGTCACAGGTAAATTCTGTTGATGC
+GAAATATCAGGAACTGCGGGCAGAACTCCATGAAGCCCGGAAAAACATTCCATCAAAAAA
+TCCTGTCGATGACGATAAATTGCTTGCTGCATCACGTGGTGAATTTGTTGACGGAATTAG
+CGACCCGAACGATCCGAAATGGGTAAAGGGGATCCAGACTCGCGATTGTGTGTACCAGAA
+CCAGCCAGAAACGGAAAAAACCAGCCCAGATATGAATCAACCTGAGCCAGTAGTGCAACA
+GGAACCGGAAATAGCCTGCAATGCCTGCGGCCAGACTGGCGGGGATAACTGCCCTGACTG
+TGGTGCGGTGATGGGCGACGCAACATACCAGGAAACATTCGATGAAGAGAGTCAGGTTGA
+AGCTAAGGAAAATGATCCGGAGGAAATGGAAGGCGCTGAACATCCGCACAATGAGAATGC
+TGGCAGCGATCCGCATCGCGATTGCAGTGATGAAACTGGCGAAGTCGCAGATCCCGTAAT
+CGTAGAAGACATAGAGCCAGGTATTTATTACGGAATTTCGAATGAGAATTACCACGCGGG
+TCCCGGTATCAGTAAGTCTCAGCTCGATGACATTGCTGATACTCCGGCACTATATTTGTG
+GCGTAAAAATGCCCCCGTGGACACCACAAAGACAAAAACGCTCGATTTAGGAACTGCTTT
+CCACTGCCGGGTACTTGAACCGGAAGAATTCAGTAACCGCTTTATCGTAGCACCTGAATT
+TAACCGCCGTACAAACGCCGGAAAAGAAGAAGAGAAAGCGTTTCTGATGGAATGCGCAAG
+CACAGGAAAAACGGTTATCACTGCGGAAGAAGGCCGGAAAATTGAACTCATGTATCAAAG
+CGTTATGGCTTTGCCGCTGGGGCAATGGCTTGTTGAAAGCGCCGGACACGCTGAATCATC
+AATTTACTGGGAAGATCCTGAAACAGGAATTTTGTGTCGGTGCCGTCCGGACAAAATTAT
+CCCTGAATTTCACTGGATCATGGACGTGAAAACTACGGCGGATATTCAACGATTCAAAAC
+CGCTTATTACGACTACCGCTATCACGTTCAGGATGCATTCTACAGTGACGGTTATGAAGC
+ACAGTTTGGAGTGCAGCCAACTTTCGTTTTTCTGGTTGCCAGCACAACTATTGAATGCGG
+ACGTTATCCGGTTGAAATTTTCATGATGGGCGAAGAAGCAAAACTGGCAGGTCAACAGGA
+ATATCACCGCAATCTGCGAACCCTGTCTGACTGCCTGAATACCGATGAATGGCCAGCTAT
+TAAGACATTATCACTGCCCCGCTGGGCTAAGGAATATGCAAATGACTAAGCAACCACCAA
+TCGCAAAAGCCGATCTGCAAAAAACTCAGGGAAACCGTGCACCAGCAGCAGTTAAAAATA
+GCGACGTGATTAGTTTTATTAACCAGCCATCAATGAAAGAGCAACTGGCAGCAGCTCTTC
+CACGCCATATGACGGCTGAACGTATGATCCGTATCGCCACCACAGAAATTCGTAAAGTTC
+CGGCGTTAGGAAACTGTGACACTATGAGTTTTGTCAGTGCGATCGTACAGTGTTCACAGC
+TCGGACTTGAGCCAGGTAGCGCCCTCGGTCATGCATATTTACTGCCTTTTGGTAATAAAA
+ACGAAAAGAGCGGTAAAAAGAACGTTCAGCTAATCATTGGCTATCGCGGCATGATTGATC
+TGGCTCGCCGTTCTGGTCAAATCGCCAGCCTGTCAGCCCGTGTTGTCCGTGAAGGTGACG
+AGTTTAGCTTCGAATTTGGCCTTGATGAAAAGTTAATACACCGCCCGGGAGAAAACGAAG
+ATGCCCCGGTTACCCACGTCTATGCTGTCGCAAGACTGAAAGACGGAGGTACTCAGTTTG
+AAGTTATGACGCGCAAACAGATTGAGCTGGTGCGCAGCCTGAGTAAAGCTGGTAATAACG
+GGCCGTGGGTAACTCACTGGGAAGAAATGGCAAAGAAAACGGCTATTCGTCGCCTGTTCA
+AATATTTGCCCGTATCAATTGAGATCCAGCGTGCAGTATCAATGGATGAAAAGGAACCAC
+TGACAATCGATCCTGCAGATTCCTCTGTATTAACCGGGGAATACAGTGTAATCGATAATT
+CAGAGGAATAATTCAGCCTGGCGGTGTAATGCACCGCCAACTTGAAATATTTTTTATGAG
+AAAAATTATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAAC
+GGTGAAAGCCATTTCAGGATATTACCGAGCGAAGTGTAACGGATGCGAATCCCGAACCGG
+TTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAACCACTGGAAATAA
+TAATGGAGGTGTTCATGTATAAAATTACCGCCACTATTGAAAAGGAAGGTGGCACTCCTA
+CTAACTGGACAAGATATTCAAAATCTAAACTAACGAAATCAGAATGCGAAAAAATGCTCT
+CAGGTAAAAAAGAAGCAGGCGTTTCCAGAGAGCAGAAAGTAAAACTGATAAATTTTAATT
+GCGAGAAACTTCAGTCCTCGAGAATTGCATTGTATTCAAATTAAAACTTCATAGCTGATT
+ATTAATAATCAACATCGGGCGTCAATTTCAGTCTAACATTGGCGCCTGCCAGAGGTGATG
+CGATGGCACAAGTAATCTTTAATGAAGAGTGGATGGTTGAATACGGCCTGATGCTTCGCA
+CTGGTCTGGGGGCCAGACAAATTGAAGCATACCGCCAGAACTGTTGGGTGGAGGGCTTCC
+ACTTCAAACGAGTATCTCCTTTAGGTAAGCCAGACAGCAAACGAGGGATTATCTGGTACA
+ACTATCCAAAGATAAATCAGTTTATCAAAGACTCATGATATGTCTAAATTACCAACAGGT
+GTCGAGATTAGAGGTAGATACATTCGCATCTGGTTCATGTTTCGAGGAAAACGATGTCGG
+GAAACATTAAAAGGCTGGGAGATTACAAACAGTAATATTAAAAAGGCCGGAAATTTAAGA
+GCGCTGATAGTTCATGAAATAAACTCCGGTGAATTTGAGTATTTAAGACGTTTTCCCCAG
+TCCAGCACTGGGGCAAAAATGGTGACAACGAGAGTCATAAAAACGTTCGGAGAGCTTTGT
+GATATCTGGACAAAAATTAAAGAGACAGAGTTAACAACAAACACAATGAAGAAAACGAAA
+TCACAATTAAAAACACTCAGAATAATAATTTGTGAAAGTACCCCGATATCACATATTCGT
+TATAGCGATATCTTAAACTACCGGAATGAACTGCTGCATGGAGAAACGCTTTACCTGGAT
+AATCCAAGATCCAACAAAAAAGGAAGAACCGTGCGCACAGTTGATAACTATATCGCCCTG
+CTCTGTTCGCTGTTGCGTTTTGCGTATCAGTCGGGATTTATATCAACCAAACCATTTGAA
+GGAGTAAAAAAATTACAGCGAAACAGAATAAAGCCTGATCCGTTATCTAAAACAGAATTC
+AATGCATTAATGGAAAGTGAAAAAGGACAGAGCCAGAACTTGTGGAAATTTGCCGTTTAC
+TCAGGACTTCGTCACGGGGAACTGGCAGCTCTGGCGTGGGAGGATGTGGATCTCGAAAAG
+GGAATAGTGAATGTCAGAAGAAACCTGACGATACTTGATATGTTCGGTCCCCCAAAAACA
+AATGCCGGGATCCGAACAGTAACACTACTGCAGCCTGCTCTTGAAGCACTGAAGGAGCAA
+TACAAACTGACCGGGCATCATCGCAAAAGCGAAATCACCTTTTATCATCGGGAGTACGGC
+AGAACCGAAAAGCAAAAACTGCATTTTGTTTTCATGCCCAGGGTGTGTAACGGAAAACAA
+AAACCTTATTACTCGGTAAGCAGTTTGGGGGCAAGGTGGAATGCAGCAGTAAAACGTGCT
+GGTATTCGCCGCCGTAATCCGTACCATACGCGGCATACTTTTGCCTGCTGGCTGTTGACG
+GCAGGAGCGAACCCGGCATTTATAGCCAGCCAAATGGGGCATGAAACTGCGCAGATGGTG
+TATGAAATTTACGGTATGTGGATTGATGACATGAACGACGAACAGATAGCCATGTTGAAT
+GCGCGGTTATCGTAGTTGCAAAGTTTGCCCCCAATTTGCCCCATTTAGTACCAGAGAACT
+GAAATAATGCAAGAAAATCAACAAATTACAAAGAAAGAACAATACAACCTGAACAAATTA
+CAAAAACGTCTGCGTCGTAACGTGGGCGAAGCCATTGCTGACTTCAATATGATTGAAGAA
+GGCGATCGCATCATGGTTTGCCTCTCCGGGGGTAAAGACAGCTATACCATGCTGGAGATT
+CTGCGCAATTTGCAGCAAAGCGCGCCAATCAATTTTTCGCTGGTGGCTGTTAACCTCGAT
+CAAAAGCAACCGGGCTTCCCGGAACACGTTCTGCCCGAGTATCTTGAAAAGCTGGGCGTT
+GAGTACAAGATTGTTGAAGAGAATACTTACGGTATCGTGAAAGAGAAGATTCCAGAGGGC
+AAAACCACTTGCTCACTGTGTTCTCGCCTTCGTCGCGGTATCCTTTATCGTACCGCAACG
+GAACTGGGGGCGACGAAGATCGCGTTGGGTCACCATCGTGACGATATCCTGCAAACGTTG
+TTCTTAAATATGTTCTACGGCGGTAAGATGAAAGGTATGCCTCCGAAACTGATGAGCGAT
+GATGGCAAACATATCGTTATTCGTCCGCTGGCCTACTGCCGCGAGAAAGATATTCAGCGA
+TTTGCCGATGCAAAAGCGTTCCCGATTATTCCGTGCAACCTGTGCGGTTCACAGCCTAAC
+CTGCAACGTCAGGTGATTGCTGACATGTTGCGTGACTGGGATAAACGTTATCCAGGGCGT
+ATCGAGACGATGTTCAGCGCGATGCAGAATGTGGTGCCGTCGCATCTGTGCGATACCAAC
+CTGTTCGATTTCAAAGGCATCACCCACGGTTCTGAAGTGGTTAACGGGGGTGATCTGGCG
+TTTGATCGCGAAGAGATCCCACTACAACCGGCGTGCTGGCAGCCAGAAGAAGATGAAAAT
+CAGTTGGATGAGTTACGGCTGAATGTGGTTGAAGTGAAATAACCAGGATAGCGCCCGATG
+CGCAAGCGTATCGGGCTACTCTTATGGAGGCCGGATAAGACGCGGCCAGCGTCGCATCCG
+GCAATCCCGAATAAGATGTTTACTCTTGCACCCGGCAATTCAACATTTCATTATTTTAAT
+AACCGCACCCGGCACGTTTTTCCTTTAATCTTCCCGCCCTGTAACTGTTTCCATGCTTTA
+TGAGCAACAGCCTGACGGACCGCGACATAGACATGCGCCGGATGCACGGCGATTTTGCCA
+ATATCTGCGCCATCAAGCCCGATATCTCCTGTCAGTGCACCTAATACATCACCCGGGCGC
+ATTTTGGCTTTTTTCCCGCCATCGATACACAACGTTGCCATTTCTGCTTCCAGCGTCGCA
+ATGGAACTATTAGCTGGCGGCGTTTGCCAGTTAAGTTTTATCTGCAACATGTCAGAAATG
+ATATTGGCCCGCTGTGCTTCTTCCGGAGCACAGAAACTGATCGCCAGACCGCTATTTCCT
+GCACGAGCTGTACGACCGATGCGATGTACATGAACTTCAGGGTCCCACGCCAGCTCAAAG
+TTCACCACCAGCTCAAGCGATTTAATATCCAGACCACGCGCAGCAACATCAGTCGCGACC
+AGTACACGGGCGCTACCGTTAGCAAAACGTACCAGGGTCTGATCGCGATCGCGTTGCTCC
+AAATCGCCGTGTAATGACAATGCACTTTGCCCTACTTCATTCAGCGCGTCGCAGACAGCC
+TGGCAATCTTTTTTGGTATTGCAAAACACCACGCAAGAGGATGGCTGATGCAAGCTTAAT
+AACCGTTGCAACAGAGGAATTTTGCCTTTGCTGGATGTCTCATAAAATTGTTGTTCAATG
+GGTGGCAAAGCATCTGTTGAGTCAATTTCAATCGCCAAAGGATCGCGTTGCACTCGTCCG
+CTGATTGCAGCGATGGCTTCCGGCCAGGTTGCCGAAAACAGAAGCGTCTGTCGAGATGCA
+GGCGCAAAACGGATGACATCATCAATGGCATCGCTAAATCCCATATCCAGCATGCGGTCG
+GCCTCATCCATCACCAGCGTATTCAACGCATCCAGTGATACCGTGCCTTTTTGCAGGTGA
+TCCAGCAAACGCCCCGGCGTTGCCACGATAATATGCGGCGCATGTTGCAACGAATCACGC
+TGCATACCGAACGGTTGACCACCGCACAACGTCAAAATTTTGGTATTTGGCAGAAAACGC
+GCCAGCCGACGCAATTCACCTGCCACCTGATCCGCCAGTTCACGCGTAGGACACAGCACT
+AAAGCCTGGGTTTGAAATAGCGACGCATCAATTTGCTGTAACAAGCCGAGGCCAAAAGCC
+GCCGTTTTGCCGCTGCCGGTTTTCGCCTGCACGCGAACATCTTTTCCGGCAAGGATCGCC
+GGAAGCGCGGCGGCCTGCACCGGCGTCATGGTTAAATAACCCAACTCATTAAGGTTCGTG
+AGTTGGGCGGGAGGCAAAACATTCAGGGTAGAAAAAGCGGTCACAATCTATTCTCGTGGT
+CATCGACGCAAAGTTAGCAGGCGCGTATCCTCGCAGATCTACGCTCACGATGCGACAATT
+TAATCGGTTCTTCATCGGGTGGTGGGTCAGGCATGGGTTGCGGGCGAGGGATCGGATCGG
+GCACTGGAACAGGATCGCCAGGAATCGGTTCAGGGACAGGAATTTGCAAATAAATAAGTG
+TCGTCATATTTCCCTCTGGTCATTGGGTGGACTCTTAAAGGGTAGACGCTGATAAATAAC
+AGGCAAAAAAAAGCCGACTCATCAAAGTCGGCGTCGTACGAATCAATTGTGCTATGCAGT
+AATTCAAAAAAGGAAGTAAGACAATATGGAGCGCAACGCCCATCGCTTGACGTTGCATTC
+ACCTGCAAGAGAGATATTGCCCTGAATGGGTAGAGAGTTTATTGACTTCGCTCAAACTTT
+GCGGCGTTTTTGTATACAGACAGCCGGAAAAATTGCTTTTGTTACAACCATTTACTACGA
+TGCAACCATAAAGCAACACCACCAATAAGAACAACTAACAGAATACAAAAAATTGAAAAT
+CCGAATTGCCACCCGCCGCCAGGGATCCCACCAAGGTTGACGCCAAATAACCCGGTCAGA
+AAGGTACTGGGTAAAAAGACCATTGCCATCAACGACATTGTATAGGTACGACGAGCTAAA
+TTTTCCTGCATCACCTGAGCGATTTCATCCGCCATCACGCCAGTCCGTGCTATACAGGCG
+TCGATTTCGTCAAGGCCGCGCCCAAGGCGATCGGCAATATCCTGCATCCGACGGCGTTGG
+TCATCGCTCATCCACGGCAAACGTTCACTGGCAAGACGAGCATAAACATCACGTTGCGGT
+GCCATATAGCGACGCATCACAATTAATTGTTTGCGCAGCAGAGCCAGGAATCCACGCGGT
+GGAATTTGCTGATCAAGGAGATTATCTTCAAGGTCGATAATTTTATCGTGCAGCTGCTCG
+ATAAATTCACTGGAATGATCGGTCAACGCATCGCACACATCCACCAGCCATCCCCCGCAA
+TCGGTCGGACCCGTGCCCTCTTCCAGATCGCTCACCACATCGTCCAGCGCCAGCACTTTG
+CGTTGTCGGGTCGAAACAATTAACCGCCCGTCCATATATACACGCATGGCGACCAGTTGA
+TCGGGGCGTTCATCGGTGCTGCCGTTTATACAGCGCAATGTAATCAGCGTGCCTTCACCG
+AGACGGCTGACTCGGGGACGCGTGCTCTCGCCCGCCAGCGCATCACGTACGTTATTGGGA
+AGCAGCGGTGTTGTCGCCAGCCATTGGGCGCTATCATGGTGTACATAATTAAGGTGGAGC
+CAACAGGGATGCGCTTCATCAATCACATCTGTATTTTCCAGCGGTTTAACGCCGCCTCTA
+CCATCCAGCATCCAGGCAAATACTGCATCCGGGACATTAACGTCCGATCCCTTAATCGCT
+TCCACAGTGCCTCCATCATCAACGCATTATTTTGTAGTCTAGCCTTCTGGCCCTGTTACG
+CAACATCTCATCACCCCATTACCCTGAAATGATTAATAAAATTCTGTCTAAATTGAATAC
+AAAAAGCAAAATGCTTTTCCGTATACAAACCGTGTGAAGTGTTAAATAGCGTCTATCATT
+ATCAGAATTATCTGATCATATGACGTGGCTTTTTTGCGATCGGATAGCAACAAAAATTGA
+TAAAAATAACGGGATCTCAATGATTACGCACAACTTCAATACCCTGGACTTACTCACCAG
+TCCTGTCTGGATCGTTTCGCCCTTTGAGGAACAGTTAATTTATGCCAATAGCGCGGCGAA
+ACTGTTGATGCAAGACCTCACGTTTAGTCAGCTACGAACCGGACCCTATTCCGTCTCCTC
+ACAAAAAGAACTGCCGAAATACCTCTCCGATCTGCAAAACCAACACGATATTATCGAAAT
+CCTCACTGTTCAGCGTAAAGAAGAGGAAACAGCATTGAGCTGTCGGCTTGTTTTGCGAAA
+GCTGACAGAAACAGAACCGGTGATTATTTTCGAAGGTATCGAAGCGCCGGCAACGCTGGG
+TTTAAAAGCCAGTCGCTCGGCAAATTATCAGCGCAAAAAACAAGGTTTTTATGCGCGCTT
+TTTTCTGACTAACTCTGCACCAATGTTGTTGATTGACCCGTCACGAGATGGACAAATCGT
+CGATGCTAACCTCGCCGCGCTCAATTTCTATGGTTATAACCATGAAACGATGTGCCAGAA
+ACATACCTGGGAAATAAATATGCTCGGGCGTCGCGTCATGCCTATCATGCATGAAATCTC
+GCATTTACCCGGTGGTCATAAACCTTTGAATTTTGTTCATAAACTGGCGGATGGTTCGAC
+TCGTCATGTGCAGACCTATGCCGGACCGATTGAAATTTATGGCGACAAGCTCATGTTATG
+TATTGTGCATGATATTACTGAGCAAAAACGGCTGGAGGAGCAGCTGGAACATGCTGCTCA
+CCATGACGCGATGACCGGATTACTGAATCGGCGACAGTTTTATCACATTACGGAACCAGG
+CCAAATGCAGCATCTCGCCATCGCTCAGGATTACAGCTTGTTGCTCATCGACACCGATCG
+TTTTAAACACATTAACGATCTCTATGGGCATTCTAAAGGTGATGAGGTGTTATGCGCCCT
+CGCCCGCACCCTCGAAAGTTGCGCTCGCAAAGGCGATTTGGTGTTTCGTTGGGGAGGCGA
+AGAGTTTGTCTTATTGCTACCAAGAACCCCACTGGATACCGCGCTTTCGCTGGCTGAAAC
+TATCCGCGTAAGCGTGGCAAAAGTGAGTATTTCGGGCTTACCACGCTTTACCGTCAGCAT
+TGGTGTGGCGCATCACGAAGGAAATGAAAGCATCGATGAACTGTTTAAACGCGTTGATGA
+TGCTTTGTATCGGGCGAAAAATGATGGACGCAACCGCGTGCTGGCGGCATAAGCCGCGGA
+TGCGTCTCGAGATCAACGACTGCGCTTAGCGTGGCGCTCCCAGTTTTCTTGCTTCGCCTG
+CGCCGTTTTACGTAGTGCGACGTAACACGCCCCGCTGCCGCCATGATGCGGTAGCGCGGT
+GCAATATGCCTGAACATCATCAAATTCGGTCAGCCAGCGCGCCACATAGCTGCGGACAAT
+ATTGGCATGCGATTTATCATCCCGCCCTTTACCATGAATAATCAGCACGTTACGCAAACC
+ATCCGCCAGGGCTTGTTGAATAAAACTGAACACCATTTTGCGGCACTCTTCCACCGGCTG
+GCGCAAAAGATTCAGGCTCGCCTGTTGCGGATATTTACCACTGCGCAGCTTATCCAGCAC
+CCCATGTTGCAACCCTTCCCGCCGAAACTCCAGCGGCTGACTTAGTGGGATGATGTCGAG
+AAATCCGGTGGTGAGGAAATTATCAAGCTGCAGCGTGTCGATACGCTGCGGCGCACGTTG
+GTTACGCGTTGGATGCCAGTGGACATCGGTAGCACGTTTCAGCGGCTGGACATCTTCCAT
+GGCGTCAAGAAACAGCGATTTGTCGTCAAGGTTCATGTTACATCCTCCCGCAATTAAGAG
+CGCGATATGATAACCAGACCGGGTCGGTCCAACAACGTATTACCCAAATTTCCAGTAATA
+AGTTCCAAATATTGCCGATATTTTAAGCAAAATACTTATGCATGATTATTCATTCACGAT
+ATTAATAATGTAACTTATATTTTCGTGAAATCTGTCACTGAAGAAAATTGGCAACTAAAG
+GTTAAAACCGTTATAACACAGTCACCGGCGCAGAGGAGACAATGCCGGATTTAAGACGCG
+GATGCACTGCTGTGTGTACTGTAGAGTCTGGCGGATGTCGACAGACTCTATTTTTTTATG
+CAGTTTTAACTTTGCAGATAGCCGCATTCTCGCCGGAATTGCGTGATTAATGACGCGGTC
+AGTGGTGTCTGGCGACTATCACGCCGCTGAATCAAATAATAGGCCGCTTTCGGTAAAATT
+TCGCTAACCGGCAACATCACCAGCCCCTGTCCGTGCAAGGGATCGCAGCCCATTTCTTCA
+GGCAGTTTGCTGAGAAAATCGCTTTTTGCCACCAGACTGATACAGGCTGAGAACGTCTCG
+CAGACTACACCGACCTGTGGCGTTTGCGCCTGATCGTCAAGCAATTCACTCAACTGTTTG
+TAGTAGCTGCCGTGTGGCGTCGGCATTGTCCAGCTGTAATCCAGTAACTGTTTGATCGAA
+CGGGCACCAATGGCGGGGTGTCCCGGGCGGCAAAAGATCGCGAATTGCTTTTCCAGTAAT
+TTCTCAAAAGTAAATTCGTGGTCGTACGGTCCCTGATAATAGGTATTGATGGTGAAATCC
+AATTCTCCCTGACGCAATTCATTAATCATCGACACCAGTTGCCCTTCCATAATGCGTACT
+TTTACCTGCGGATGCTGCTGATGAAAACGAGATATGACAGCTGGCATCAGACTGCGGGAA
+ATACTGGCCCCCATGCCGATATTAATCTGCCCTGCCAGTTGCCCTTGTCGTTGGCGAATA
+TCCTCTTGGGCTGCGCGCAGCTCTTCAAGAATTAGACTGGCGTGCTGATAAAAACTTTCA
+CCGGCATCAGTTAACGTCACGCCTTTACTACGGCGAAAAAAGAGTTGCGCCGCTAACCCT
+TCTTCTAGCTCCTGAATAGATTTACTCAGTGCCGGTTGCGACATATTCAACATTCGGCTC
+GCTCCGCGAATGCTGCCCTGACGAGCCACTTCAACAAAAGCCCGAATTTGATGAATTTTT
+ACCTGAAAAGCCATGACGCCACCGATAACCGTTATTTATCAGACCAAAGAAACTGGCATC
+TACTTTAATGCAGATGATTGTGTCAGGGTAATTTATGAACGGTTAAAACTGTGAAAAATC
+AGTTAGTGATAAGTAAAAACTATCGCTACGTGAACCGGGTCACACTTTTTACTGATGACG
+GGAAAGGTTATGGAGTCTTTGAATCAATTTGTTAATTCGCTTGCCCCAAAATTATCGCAC
+TGGCGACGTGATTTTCATCACTATGCAGAGTCTGGCTGGGTGGAATTCCGCACTGCCACC
+CTTGTTGCGGAAGAATTGCACCAGCTCGGCTATTCACTGGCGCTGGGTCGCGAAGTAGTT
+AATGAAAGTAGCCGGATGGGATTACCTGATGAATTCACTCTACAACGCGAATTCGAGCGC
+GCTCGTCAACAGGGTGCGCTAGCACAATGGATTGCGGCTTTTGAAGGTGGTTTCACTGGT
+ATCGTCGCCACCCTGGATACCGGTCGCCCCGGTCCGGTGATGGCTTTCCGTGTCGATATG
+GACGCGCTGGATCTCAGTGAAGAGCAGGATGTCAGCCATCGCCCCTACCGCGACGGTTTT
+GCGTCATGTAACGCCGGAATGATGCATGCCTGTGGTCATGATGGACATACCGCCATTGGG
+CTTGGGCTGGCGCATACCCTTAAACAGTTCGAGTCCGGACTACATGGCGTCATCAAACTG
+ATTTTTCAGCCTGCAGAGGAAGGTACGCGTGGCGCGCGGGCGATGGTCGATGCAGGTGTC
+GTAGATGATGTTGATTATTTTACTGCCGTGCACATTGGCACTGGCGTACCTGCGGGCACC
+GTGGTGTGCGGCAGTGATAATTTTATGGCAACCACCAAATTTGACGCGCACTTCACCGGT
+ACCGCCGCTCACGCAGGCGCAAAACCAGAAGACGGTCACAATGCCTTGTTGGCGGCAGCA
+CAAGCCACTCTTGCACTGCATGCAATCGCCCCGCACAGCGAAGGAGCTTCCAGAGTAAAC
+GTGGGCGTTATGCAGGCAGGAAGCGGTCGTAACGTTGTTCCTGCCTCGGCGTTGCTGAAA
+GTGGAAACACGCGGGGCCAGCGACGTCATTAATCAATATGTTTTTGACCGTGCACAACAA
+GCGATTCAGGGCGCAGCAACCATGTATGGTGTCGGCGTTGAAACTCGTCTGATGGGTGCA
+GCTACCGCCAGTTCTCCTTCGCCGCAATGGGTCGCATGGTTGCAAAGTCAGGCGGCTCAG
+GTCGCGGGGGTCAATCAGGCCATTGAACGTGTTGAAGCGCCTGCGGGTTCCGAAGATGCC
+ACATTAATGATGGCCCGCGTGCAGCAACATCAAGGGCAAGCCTCCTACGTGGTGTTTGGC
+ACACAGCTGGCGGCAGGTCATCACAACGAAAAATTCGATTTTGACGAGCAGGTTCTCGCT
+ATTGCCGTCGAAACGCTGGCGCGCACCGCGCTCAATTTTCCCTGGACGCGAGGTATCTGA
+TGCAGGAAATCTATCGTTTTATCGACGATGCGATTGAAGCCGATCGCCAACGTTATACCG
+ATATTGCCGATCAAATCTGGGATCATCCAGAAACACGTTTTGAAGAGTTCTGGTCAGCGG
+AGCATCTGGCTTCGGCGCTGGAATCTGCAGGCTTCACCGTTACCCGCAACGTAGGCAATA
+TCCCAAATGCCTTTATTGCTTCGTTTGGTCAAGGCAAACCGGTTATCGCCCTGCTGGGAG
+AATATGACGCCCTGGCAGGTTTAAGTCAGCAAGCAGGTTGCGCGCAACCTACATCCGTGA
+CGCCCGGTGAAAATGGTCACGGTTGCGGACACAATTTGCTGGGAACCGCCGCCTTTGCCG
+CTGCAATAGCCGTCAAGAAATGGCTGGAACAATATGGGCAAGGCGGCACGGTGCGCTTTT
+ATGGTTGTCCTGGCGAAGAAGGCGGCTCGGGTAAAACGTTCATGGTTCGCGAGGGGGTAT
+TTGATGATGTGGATGCGGCACTCACCTGGCACCCGGAAGCCTTTGCCGGTATGTTCAATA
+CCCGCACGCTGGCAAACATTCAGGCATCATGGCGCTTTAAAGGGATCGCAGCACATGCCG
+CGAATTCCCCTCATTTGGGACGCAGCGCCCTTGATGCCGTAACGTTGATGACCACTGGCA
+CCAACTTCCTCAACGAACATATTATTGAAAAAGCGCGCGTACACTATGCCATCACAAATA
+GCGGCGGGATCTCGCCCAACGTGGTCCAGGCGCAGGCAGAAGTGCTTTATCTTATCCGCG
+CCCCCGAAATGACCGACGTGCAGCATATTTATGATCGGGTCGCCAAAATCGCCGAAGGTG
+CGGCATTGATGACCGAAACCACGGTTGAATGCCGCTTCGACAAAGCCTGTTCCAGTTATC
+TCCCGAATCGCACCTTAGAAAATGCCATGTACCAGGCCCTATCCCATTTTGGTACCCCGG
+AATGGAACTCCGAAGAACTGGCTTTTGCGAAACAAATTCAGGCTACGCTCACCTCCAACG
+ATCGGCAAAACAGTCTGAATAATATCGCCGCAACCGGTGGCGAAAACGGCAAGGTTTTTG
+CACTACGTCATCGTGAAACGGTACTGGCGAATGAAGTCGCTCCATATGCCGCCACCGATA
+ACGTGCTTGCGGCATCGACTGATGTCGGCGACGTCAGTTGGAAACTGCCTGTTGCCCAGT
+GTTTCAGCCCCTGTTTTGCCGTCGGTACACCGCTACATACGTGGCAACTGGTTAGCCAGG
+GGCGAACATCTATTGCTCATAAAGGAATGCTGCTGGCGGCGAAAACTATGGCAGCAACCA
+CAGTCAATCTCTTCCTTGATTCAGGGCTATTGCAAGAATGCCAACAAGAGCATCAGCAAG
+TAACGGACACGCAACCGTATCACTGCCCTATCCCGAAAAACGTGACACCGTCACCTTTAA
+AATAACAACAACAACGCAAACACAACAACCGAGGAATGCCCATGAGTATGTCATCCATAC
+CGTCGTCCTCCCAATCCGGGAAGCTCTATGGCTGGGTCGAAAGAATTGGTAACAAGGTTC
+CCCATCCTTTTCTGCTCTTTATCTATTTGATTATCGTACTCATGGTGACGACGGCAATTT
+TGTCGGCCTTTGGCGTCAGTGCGAAAAACCCGACCGATGGTACGCCGGTCGTGGTGAAAA
+ACCTGCTCAGTGTGGAAGGATTACACTGGTTTTTACCCAATGTTATTAAAAACTTTAGCG
+GTTTTGCTCCACTTGGTGCGATCCTGGCGCTGGTTTTAGGTGCCGGTCTGGCGGAGCGCG
+TCGGCTTACTGCCAGCACTAATGGTTAAAATGGCATCGCATGTTAATGCCCGCTACGCCA
+GTTATATGGTGCTGTTTATTGCTTTTTTCAGCCACATTTCTTCCGATGCGGCGTTAGTGA
+TCATGCCACCGATGGGTGCGCTGATTTTTCTGGCGGTGGGCAGGCATCCAGTTGCAGGTT
+TACTGGCTGCCATTGCAGGCGTAGGTTGCGGCTTTACGGCTAATTTACTGATTGTCACAA
+CCGACGTGTTGCTGTCGGGGATCAGCACGGAAGCGGCAGCTGCGTTCAATCCGCAAATGC
+ACGTCAGTGTAATTGATAACTGGTATTTTATGGCCAGCTCCGTAGTCGTACTGACGATTG
+TTGGCGGCCTGATAACCGACAAAATCATCGAGCCACGGTTAGGTCAATGGCAGGGAAACA
+GCGATGAGAAACTGCAGACATTGACCGAAAGTCAGCGTTTTGGTTTACGCATAGCAGGTG
+TCGTATCGCTACTTTTTATTGCTGCGATTGCGCTGATGGTGATCCCGCAAAACGGGATAT
+TGCGCGATCCGATTAATCACACCGTGATGCCATCACCCTTTATTAAAGGTATCGTGCCAC
+TGATCATTCTTTTTTTCTTTGTTGTCTCGCTGGCTTATGGCATCGCTACCCGCACAATTC
+GACGTCAGGCGGATTTACCGCATTTAATGATTGAACCGATGAAAGAGATGGCGGGATTTA
+TCGTGATGGTTTTTCCCCTCGCCCAATTTGTCGCCATGTTTAACTGGAGCAACATGGGGA
+AATTCATCGCCGTGGGGCTGACCGATATACTGGAAAGTTCAGGGCTTAGCGGCATCCCGG
+CGTTTGTCGGTCTGGCGTTGCTTTCCTCTTTCTTATGCATGTTTATTGCCAGCGGTTCCG
+CAATCTGGTCGATTCTCGCCCCCATTTTCGTACCAATGTTTATGCTACTTGGCTTTCACC
+CGGCATTTGCGCAAATCCTCTTTCGTATTGCCGACTCATCCGTATTGCCTTTAGCGCCGG
+TATCTCCTTTTGTTCCACTGTTTCTTGGATTCCTGCAACGCTACAAACCAGACGCGAAAC
+TGGGTACTTACTATTCGTTAGTCTTGCCCTATCCACTTATCTTTTTGGTGGTATGGCTGC
+TGATGTTGCTGGCGTGGTATCTTGTCGGTCTGCCGATAGGTCCGGGTATTTACCCACGTT
+TGTCTTAAGAGAGAACGGATGCTGAGATTACTTGAAGAAAAAATTGCCACGCCACTGGGT
+CCACTGTGGGTGATTTGCGATGAGCAATTTCGCCTGCGGGCGGTTGAATGGGAAGAGTAC
+AGCGAACGCATGGTGCAGCTGCTGGACATCCATTATCGCAAAGAAGGCTATGAGCGCATT
+TCTGCCACCAATCCAGGCGGTTTAAGCGACAAGCTTCGTGAATATTTTGCCGGTAATCTT
+AGCATTATTGATACGCTTCCCACTGCTACGGGGGGGACGCCATTTCAGCGCGAAGTCTGG
+AAAACACTACGCACTATCCCCTGCGGGCAGGTAATGCATTACGGCCAACTGGCTGAGCAA
+TTGGGCCGTCCTGGCGCGGCGCGTGCCGTTGGTGCGGCAAACGGATCGAATCCCATCAGC
+ATCGTCGTACCTTGCCATCGGGTTATTGGCCGAAACGGCACCATGACCGGATATGCAGGC
+GGAGTTCAGCGAAAAGAGTGGTTATTGCGCCATGAAGGTTATCTTTTGCTGTAAACATTA
+AACAATTTGTGCCAGCTTGTTCACACTTTTATGTAAAGTTACCCTTAACAACTTAAGGGT
+TTTCAAATAGATAGACATATATTTACATCTAATATCGGAATTCTCTGCTGTTAAGGTTTG
+CTTAGGGAAGGTGCGAATAAGCGGGGAAATTCTTCTCGGCTGACTCAGTCATTTCATTTC
+TTCATGTTTGAGCCGATTTTTTCTCCCGTAAATGCCTTGAATCAGCCTATTTAGACCGTT
+TCTTCGCCATTTAAGGCGTTATCCCCAGTTCACAATATAGTTAAATGCGATGTTTTTGAC
+GGTGTTTTCCGCGTTACCAGCAGCGTTAACGGTGATGGTGTGTCCATGTGAACCAATCGC
+AACGGAGTGCGTATGAGCACCAATACCGACAGTATGCGCGTGTGCACCTGCGCTTGCAGC
+AGTGCCGGACAGTGAGTGGGTATGTGCGCCAGCAGATGATGTTGCATAGTTTTGATTATG
+CACAACAGACAATCTTGTTGATGCACTACCAGCACCGGAGTTAGCACTAGCCGTGTTCAC
+GTTGGCTAGTGAGTGTGTGTGTGCTCCAGCCGAGTTTGTAGAGCCGCTCACACTGTGTGT
+ATGTGCCCCGGTGTTATTCGTGGATTTAGTGCCGTAATCAAACGACGATGTGGTTTTCGT
+CCCCAAATCTGTACTGGATGCGCTGGCGCTGTGGGTATGCGATTTAATGCCGTCCTGTTC
+CTGAGACAATACGGCCCGACCACTGGCAGGTTTGCCCTTAATCGTCCAGCCACGCATATC
+AGGGATCACGCCTGACGGATAAGCGGCTGCAAGTTTCGGGTAAGCAGATTTGTCAAAAGC
+CTGCCCCTGCATCAGGGCATAACCAGACGGAACGGTATCTGATGGCCACGGGATTGGTGC
+GCCGACTGGGTAGCTTTCTGGTGGAAGATTTTTCGAGGTATAAACTTCTGCCCAGTCTTC
+CTCAAAACCATAACCGTCTCTTGAAGAACGGTAGAACAGACCACCATTTCTGTAATGCGC
+CTTCATCTGCAGGGTCCGGCAACTTCCGACTCCGGTATAGAAGTTAACCAGAATATAGCT
+GTCGCCAGAGCGGGTGACATTGTAAGCGCCAGATTCGGCATTCCATGGAACGCCACCATC
+CGCATCGGCATATGTATCCGTTGCCCTTCTGGCAAAAGCAGCCACATGCGCGGCGGTTAA
+AGTAATATCTTTGGAACCATCAAACTCAACACCAGAAACCCGTCTTGGCGTTTGCAGCTT
+TGTTGCTGTTAATGCATTACCGTTCAGACTTGCGGACAGTTTGGTTCCAATAACCAGTTC
+GCCGGTTGCGTTATCAATAGCAAACGGTCTTAATGTATTCCAGCCACCATAAACATCACC
+TTGATTGGTAAGCAGCAGGTAAGTTTTAGCGCCATCATTACGCCATAATGCACCATACTC
+CCCACCTATCATTCGAATCTGATTACCACCACGCGCTACAATTTCGTCTGTGGCAAAAAG
+TTTTTTGCACGACAAGTTATCGTTAACGATTAACGAATGAGACTCATAAAAACCACGCCC
+ACTCTTAAAATCAAGGATAACGTCCGCCGCGATACATTCAGTCGCCGGATTTGTTGCCCC
+AAACTTATAGGTCGTATCATTAACAACGAGATCAGCACCAGGTGCGGATATTGACAGGCC
+ATCTTCAATAAACGCAAAAACAGGGAAAGCAGCGCCATCAACATAGAACACAGAGCGCAA
+ATCATCGCCCTTATTACTCATCATTATTGAGTGAATGGCTCGTTCATTGTTTTGATATTG
+CCAGAACATGCCATAAGCATAACGCCCCCTGTCAGTCCAGCCACCAGGCATAACAAATCC
+GTTAAACTCGCAGTTATTCATCGGATCGCCTGCGGTTCGCGTTGCCGTGGTGATAATGAC
+TCTTGATGCCAGTTCGCTTACTGAGCCAGCAGAACGCATAACAACAACAGGGTAATATTT
+TCCAGATGTTGCACCTGCAGGAGCGTTAACCCGCACATAACGCATACCACGCTTATCAGC
+AAAGTCTGTTTTACTGACCGCGTTAATGTTGTTCAGGAAGCATCCCTTATCGGGTATATC
+AGCGCCGTTCTGGTCTTTCTGCAGACGTTTCTCTGCATTGTCATAGGCTGATTTTACTGC
+CTTTGGCGTTGCCGCCAGCGTTTCAGACGTACTGTTGGTCGCACTGCTGAGCTGTACTAT
+CCCCTTTTTCGTCGTACTTGCATCCTCAAGCGCCACGGCGGATGCAATATCCTCTGCCCG
+TTTAGCTGCTGTCTCGGCGCGCGTTGCCGCGGATTCCGCCGTACTTTTGCTCTGAGCTGC
+CGCCGTCGCACTGCCAGCAGCCTCTGTCGCCTTCGTGGATGCCGTCGTGGCGCTGCTCTT
+CGCTGCTGACGCTTGTCTGGTCGCCTCATCTTTTGAAGCAGACGCCGATGATGCCGATGA
+CGCCGCCGAACTGGCTGACGATGCGGCAGCCGTTTTTGAGGATTCTGCGCTTGTTTCCGA
+CGCTTTCGCGTTCGTTTCGGATGTCTTCGCTGCGGAAGCAGACCTCGCTGCTGCGCTGGC
+CTGTTCAGTGGCTTCGCCAGCCTTCGTTGTGGCTGTTGAAGCAGACGATGCGGCGCTTTC
+TGCCGATTTTCCGGCGGCGGTGGCACTGGCTGAGGCCTGCCCGGCACTTGTTGACGCTGC
+ACTGGCAGACGACGCAGCCGCTGTTTTTGAGCCTGCCGCAGCCGAGGCGCTCTGTCCCGC
+TGCCGTTTCAGAAGACCTGGCGTTCGTCTCGGACGTTTTTGCCGCCTTCGCGGAATTTCC
+TGCCGCCGTTGCCGAGGAAGCTGCACTACTGGCGCTTGATGATGCGTTCGTTTCTGATGA
+TTTTGCCGCTTCTTTTGAGGCCGCCGCATCCCGGGCCGAGGTCGCAGCTTCTGATGCCTT
+CGTGGTCGCGGTGGATGCAGATGTGGCTGCTGATTGTAGTGACGCTGAAGCATTCGTTTC
+TGACGTTTTCGCCGCACCGGCACTGGTGGCCGCCGCGCTTTTTGAGGACTCTGCAGCGGC
+AGCACTTTTTGATGCTTCAGTGGCCTTTGTTGATGCCGTTCCTGCGCTGGAAGACGCTGA
+CTGAGCCGACGACGCGGCCTGTCCGGCTGACGTGCTGGCTGCGCGTGCTGAGTCCGCAGC
+ATCAGCCGCATGGGTTGCCGCCTCACGGGCTGATGTGCTGGCATCACTGGCTGT
+>NODE_17_length_39819_cov_63.5061_ID_33
+TTCAGCTTTCTTCGTTTCATTCCATTCCAATAAAATTTTATGATTTTCTTCAGGAAGAGT
+AATGTTTATTTTTCCAATCGGCTCGTCTTTATGATAATTATTTATCACTAATTCTAATAG
+ATTCATAAATCTTTCTTTATGCAATGCTAGTTCCGCGCCGTTATATACTTCCGGATTCGC
+ATCAAAATGAATCATTAACTCATTTTCATCGAAGCGCTTATATACATTAATCGATAAGTC
+ATCGACAGGTCCTGCTGATAAATTATGTGTAATACCACGATTTCCAGCAAAGTTAAGCCC
+GTAATCAAAAGGCATAACATTCACTAACGGCCCAAACAACCTTTGATTTTCACCTAGTAA
+CTTTAAGTCTCTTCTTAATTCCTCATGACGATATTTATGATGACGACGTACGTCTCGAAT
+TTCTTTAGAAACTTGCTGTATTAATTCTACAAAAGTTATATTTGGAGTTAACTTTAGACG
+AAGTGGAACTAAATTCATTACCATGCTAGGTGTATGAATAGATACAGAACCAAGACGCCC
+CATCATCGGTAAACCTAAAACAATATCATTTGCACCTGTTAATTTATGCATATAAATACT
+TGTTACAGCTACAACAAATTCGGGCCAACTCGTTAACGAAATATTAATATCTTCTAGTAA
+AGTTTTCGTACTAGCATTTGATAAATAAGCAGTTTCTCGTAAAAATCCATTTGATGTTCT
+CGGCGCTTGTTCTGCTAAACTTATAACTTCCGGTTCATCTGCAAACTTTTCTAGCCAAAA
+AGTACGATTTTCCTGAAATTGTTTAGATTCACGATACTCATTATCTTCTTGTACAATTTT
+GGCAAGAGAACCAAATGGCTTTTCATTCTTATTTGTTTCTTCTATAAGTGATGTATACTC
+ATTCGCTACCTTTTGGCTAAGAAGTGAAAATCCATAGCCATCCATCACAATGTGATGGAT
+GCGCTGATACCAAAAGAAACGATTATTTTCAACTTGAATAAGTGCTTCAGTAAATAATTT
+ATCTTCTTTTAAATCTATCGGTACAGATAAATCATTTTTCATCCATACTTTAGCAGCTTC
+TTCAGGATTTCCCTCTTTACGAACGTCAATAAAATGCATATGAAACGTTGACGATTCCTC
+AATAACTTGCCATGGGCCAATTTCATCCTCTTCGAAACGAACATGAAGTGCTTCTGCTTC
+TTTTACCACTTTACGTACAGCTAACTCGAAAATTTCATGATTAATATTTCCGTTTATTTC
+TATATATTCCCCAGTATTATAAATCGGATTAAGCGGATCTAATTGTTGCGCAAACCACAT
+ACCAGACTGCGCAGATGATAACGAATGGCGAATCTTTTGACTATTAGGCATTCTTTACTA
+CCCCTTTATTATGTAGTCTATTTGTTACAGCACTTGTGCTGCTTGTGAAGATAGTAAACG
+GTACCAATCATCAACAGTTGGACGTTCTGCTAAATCTGCAAAAGTGATTTCTTTCCCTTC
+GCGGCGCCACTTCTCTACTAAACTCATAATTCTGACCGAATCAAGTCCTCTATTTAATAA
+GTCTTCATCAACTTCAATACTCTCTACTGGCTCACGGAGTAGTTGTGCAACTAGTTCATG
+TACTTTCTGTAAAGTGATTCCTTCACTCTCATCGCTTTTTACACTTTGTAAATCTTTTAA
+TAGTAAGTTTGTTGATGTCGTTACTGCACATCTATTAGATGCATACTGCAATGCTTGTTT
+ATGATGCTCTAGCGAAAAATCAGCAACTGCATCTGCTACAAAAAATGGCTCTATACCATC
+CATAAATGCTTCACAAGCTGTTAAAAGGCAGCCAATATGCGCATAAATACCGCAAATAAT
+AAGTTGATCTCTTCCCTGCTCATTTAAAATTTCTAATAGATTCGTCTTTTTAAATGCACT
+ATATCTCCATTTGGTTAGGAATATATCATCCTCATCTGGAGTAAGCTCATCGACAATTTT
+CTTTTTATCTGGTCCAGCAGGAATACCGTCACCCCAAAAGTCTTGTAATAACCCTCGTTG
+TTCTAACGTTTGTCCACCAGGTTGTGCTGTATAAACAACTGGTATACCAAGTTCCTTGCA
+TCTTTCTCTTATCACCTTAATATTTGAAATTAGTTCTACTTTTGGCGATTCTTTATCGCT
+ATATGCATCAAGAAAATATTCTTGCATGTCATGGATTAGAAGAACCGCACGTTTCGGATC
+TGGCGTCCAATTCACTTTATTTTTTGGTAGTTCTGATTCAATTGGCATTTTATATACTGA
+AATAGATGGGATAGCCATCTAATCACTTCCTTCCGATTTTTATTATTGTTTTACTGTAAT
+AAGTTTTTCAGCAATGACTTTACGTAATTCTTTTTTGCTTACTTTTCCAACACCTGTTTG
+TGGGAATGATTCAATAAATTCAATTCGATCTGGAATCTTATAAGCTGCTATACCACGTTC
+TCTTAAGAACATTTTTAATTCGTTTGCAGTTAGGACTTGTCCACGAGCGATAACAAAAGC
+GCAAGTGCGTTCTCCTAAATAATCGTCAGGCATAGATACAATTGCTACATCATGTACTGC
+ATCATGTGCTAATAGATGATTTTCAACCTCTTCCGCAGCAACCTTCTCACCGCCACGATT
+AATTTGATCTTTATCTCTTCCTTCTACAATGATGTAACCTTGTTCATTTACTTTCACAAG
+ATCTCCTGTACGATAAAATCCATCCTTTGTAAATGATCGTGCATTATGCTCTTCCGCTTT
+ATAATAACCACGAATTGTATATGGCCCTCTTGTTAATAAACTTCCTACTTCACCGGGTTT
+TACATCGTTATCATTTTCATCAACAACCCTTACTTCATCGAATGTAGACATCGGTCTACC
+TTGCGTATGAATAATGATTTCTTCAGGATCATTTAATCTTGTGTAATTTACTAACCCTTC
+TGCCATACCGAACACTTGCTGTAACGTACATCCAAATGTAGGGCGAATACGCTTCGCAAC
+TTCGGCACTAAATTTCGCACCTCCTACTTGAATAACTTGCAGGCTCGATAAATCGTCGTT
+ACGGGAAGATGCTGCATCAAGCCAAATCATTGCTAATGGTGGAACGAGCGCTGTAATCGT
+AACTTTTTCTTTTTCTATAAGAGCAAATGCCTCATCTGGACTACCTCCAGTTGCCAATAC
+TACTTTTCCACCCGCATAAAAAGTTCCAAATGTCCCTGGAGAACTCATCGGGTAATTGTG
+TGCTACTGGAAGAACTGCCATATAGACACTTTCTGCATTTAAATTACAAATGTCAGCGCT
+AACACGTAAACTATAAATATAGTCATCATGTGTTCTAGGAATTAATTTAGAAAGTCCTGT
+CGTCCCTCCTGATAATTGGAGAAACGCAACATCACTTGGCTGAACTTCTGGTAACGGAAT
+CGGATCCATATAAAGATCAGTTATGTTCACGAATTCTTCTTCTTCCCCCACTACGATTAC
+ATGTTGTAAAGCGGGAACTTTCTCTTTCACTTCTCTTGCTAGTTTTCGGTAATCAAAGCC
+GAGAGCCTTATCTGAAATAATGTAAGCACTCGCCTCACCGAACTCGCAAAAATAACTAAT
+TTCACTACTGCGATGAGAAGGTAGTGCAAAAACAGGAAGTGCTCCAATGCGAAATAGCGC
+AAAGCATATTTCGAAAAACTCTATAATATTAGGTAACTGGATTACAACTCGGTCCTCTTT
+CTTTATTCCTAAATTCAGTAAACCTGAAGCTAAGCGATCTACCTTTTTATCAAGTTCACT
+ATACGTTATATGCGTATTACTACTTACAACCGCAATTTGATCCCCATATTTTTCAGCACG
+TTCTTTTAACATCGAACCAAATGTTTCTCCAAGCCAACACCCTTCTTCTCGATAGCGATT
+GGCAAATTCTTTTGGCCATTCCGTATAACCTATTAACATTCTTTCTTCCCCCTATTTTTC
+ATTCAGCAAATTATCTCTTAACCCTAAAGCCTTCAACATTGTTTGGAACTTAGCTGATGT
+TTCTGCTAACTCATCTTCTGGCTTTGATTCAGCAACAACTCCAGCACCTGCATATAAGCG
+AAGTGTATTCTCTTGCACTTCAGCACAACGAATTGTAACAATCCATTCGCCATCTCCATC
+TAAATCGCTCCACCCTAACATTCCTGTAAAGAATTCACGGTCAAATGGCTCAATTTTTTG
+AATAGCCTCTCTCGCTTCTTCCATTGGAGTTCCGCAAACTGCTGGCGTAGGATGAAGAGC
+AATTGCTAATTCTAAAGAAGACGTATTTGGGTCCTTTAGTTCACCTTTCACTTCCGTAGA
+CAAATGCCACATTGCTTCACTATGAATAACTGAGGGTTTTTCTGGAACATGTAATATATG
+ACAGTAAGGGCGAAGCGCAGCGGCAACCGCTTCAACTACTACCGCATGTTCATGTAAATC
+TTTTGGAGAAGAAAGTAATTCTTCTGCCCTTCTTTTATCTTCTACTGGATCCTCACTTCG
+TGGTCTTGAGCCAGCCAACGGATTAGAAATTACTTGCATACCATGACGTGAAACAAGTAA
+TTCAGGACTTGCTCCAATTAACGTCTTACTGTACTCGTTTTCATCTTTCGGCAAATTAAC
+AGCAAATGTGTAGCCGTGCTTATTATGTTCCGCTAATTCACGAAGTAGTTTTTGTTGATC
+AATTTTCTCGGAAGACTTAACATCCAATGATCTAGATAGAACGATTTTCCTTAAATCTCC
+GTCCTGAATTTTTGCTATTCCTTGCTTCACACCATCCATATAAACTTCAGGAGCTGGAAC
+CGGTGTCATTTCAAATGTCAGTTTCTCATTTCGTTTTATCTCATTTGTCGTCTCTAACTG
+TAAACGCTCAGTAATTCTACTATGTTCTGGTACGATAAGTTGAACTTCTTTTCTACGATC
+AAAGGGCAAAGCACCAACAGCGATAGGATTCGGATTTCCGGCTTGTTTTGCATTACTTAA
+TACCGCTTGTACAAGTTCTGGAAAGCTTTCAATTTCACGATGTTTTACTGTAGTAAACTC
+TCCTTCTGCTAATATTGTTCGAGTTGGTGAAGCGAAAAAGAATGAAGATTCTGTCTTATA
+ATCTTCTAAAAGTTTTTCTGACAGTTCCTTTACGGCTGTAAGTTCATTCATAGTATAATA
+ACCTCCTGAATTTTTTATTAAACTCCTAATGTAGCTCCGCCATCGACACATAAATTGTGC
+ATTGTAATATGACTCGCTTTATCAGAAGCTAAAAACAATACTGCTTCAGCAATTTCTGAA
+GGTTGTGCAATTTTTTGTAACGGAATACCGAGTCTATATGTATTTTGAGAACCAGCAATT
+ATATTTTCAGCTCCATTCTCATCAGCCCATAGTAATCTTTGCATTTCAGTTTCAGTAGAA
+CCAGGAGAAACTAAGTTGCAGCGAATATTGTATGCTGCAAGCTCTAACCCTAAACACTTC
+ATAAACATTGTCGTTGCGGCTTTTGATGCAGCGTACGCAGCCATTTCCATTCTCGGAGTA
+TTTGCCGCATTTGAACCAACTGTAACAATTGCCCCTGACTTTCTTTGCATCATATGTTTA
+CTTACTGCTCGAGACATATAGAAAACTCCTGTAGAATTTACAGAGAAGGTTTTATTCCAA
+TCTTCATCACTTAAAGAGTGAATTGGTCCCATACGTAATATCCCTGCAACATTTATTAAT
+ATATCTATTGGTGCTATATCATTTTCAATACCGTTTACCATATCTTCAACAGCGGTACTA
+TCACTCACATCTAAATGAAATATTTTCATACGTGTTTCATTTAATTCATTTTCATTTAAG
+AGTACGTTTAACCCCTCTTCATTTTGATCAACCGCAATAACTGTAGCTCCTCTTTCTAAA
+AACATTTTGGCAACAACACTGCCTATACCTTGAGCTGCACCTGTTACTAAAACCGTTTTT
+CCATCAAATTCCCCTAAGTTCATTTCCTCTATCCTTTCATTTGAAAATTAATCTAATTAA
+ACAAATAGCAATAATGATAACGATTATCACTATCAATGTAAAAAATAATACACTTACTAA
+ACTAATTGGTCAAGTGTACTTTTCATCAAAATATTATTCATTGATAATGTTTTTCATTTA
+ATATTCTTACATCGAAATGATAATCTTTCTCAACAAACTTGTCAACCTATTTTTATTTTT
+CAGATAAAATATTTTAGTACTTCTCAATACAATTACATCTAAAAGCATTAATAAGTACTT
+ACATTAAAAAATTTAATTCGTACTCCTCTTTTTAAAATTGAAGAAGATAAACTTTAGATA
+CCTTCATTTACAAAGCCTTACCAAAAACTCAAGTATATATTTTCTCAACATTTTTCTGAA
+AATATCAAGAAAGTATATCTTGCAATTACCGATGCATGTCGTGTTTATAATTTAAGATTT
+AATAAGTATTTCGAATATAATATATCAATTTATGATATTCCAATATAATCCAAACGGATA
+CTTTACTCATTTTTTTGCCTCTAGAAAATTCCACATGTTGTAATTCATAAAAAAGCACCC
+TATTAAATAGGGTGCTTTTTAGTAAACATAGTGTTAAAGAAGATTTATATACTTACGCTA
+CACTGCGATACTCTTCTTCTTTTTCTTTTTTCTGCTTAGGCACTTGGATTAAAAGTGCGA
+TAATAAATGATACGACACATAATACGCCGATCACCATGAAAGTTGGTTTGAATCCACCTA
+GAACTGCACCGATAAAGGAACCAGCGAGCGCTCCAAATCCAAATCCTTGATACACAATTC
+CGTAGTTCTTACTATGGTTTTTCATACCGTAGAAATCACCAACGATAGCTGGGAAAATAG
+TGATATTTCCACCAAAGCAAAACGCTACACTTGCTACACATACGAAGTAGATACCATAAT
+TTAAATCTACGAAACTTAAAACCAAGACTGACGCTGCCATAACAACAAATGTACCAGTAA
+CGATTTTTAAACGGCCGATTTTATCTGATAACGGTCCTAAAATAATACGACCTAATGTAT
+TGAAGATTGCAACCATAGCCACCGCATTAGCTGCTGTCGCTGCGCTAAGCCCTACAAGTT
+GAACACCAATGTCTTTTACCATACCAATTAAGTATAAGCCACTCATACATGATGTAAATA
+ACATAATAAATAATAAGTATACTTGTTTTGTGCCCAACATTTCTTTCGTTGTATATTCCT
+GAGTTTTTGTTTCATGAACTGCTCCTTGATCTGCAGCTTGATGGATTAAACAAGCGCCAA
+GGACAATCATAGCTGTAACAATTAAACCCCAGTATATAAACGCTTGTGATACACCAACTG
+ATTCAATTAACTGTGCGTTAATATATTTAAAAATTAAGCTACCTGAACCATATGCAGAGA
+CAGAAATACCAGCAATTAAACCTTTACGCTTTGGAAACCACTTTATTAAATTGGATAATG
+AAGTGATATATGCTGTACCATCTGCATAACCTACAACAACCCCTGCTAGTACATAAAGCA
+ATATTAATGAGGAAGCTTGTGAACTAAGTATTAATCCAATTCCTAATGCTAGTCCAGCTA
+TCATAATAAGTTTACGAAGTCCCCATTTTTCTTGCAATTTACTCGCAAACAAAGTTGAAA
+ACGCTAAAGACAGGCTAGTAATTGAGAAAGTTATAGCAACAGCGTTAAGACTCCAACCGT
+ATTTACTCACTAAGGGCTGATTGAATAAACTCCATGTATATATCGTACCAAGCCCCATTT
+GTACTATGACTGTTCCAAGGACAACAAGCCATGGATTAACCGATGATTTTTTCATACCAT
+CTCTCCTCCTCTTTCTATTTCAATGCTATTCGCTAAATATGCTTTTTTTATTTTTATTTT
+CGCCACCTCATTCGACTTAACAACTTCATTGTATAGGATGTTTTCGCTTATGTAAGCACT
+TACAAGATGGAGCGTCAAAAATATGGAATCAGTTACAGAAAACGAAGGGTGAAATACAAA
+AAACTACTTGTTAAATACGTAGTAGTTTTTATAATGTTTTACATCAATACGACTTATGTG
+TGTTTTCATATCCTCTTTTATACAAAGTTATGCGCCCTGTTACACCATGGCTGGACTTCA
+AAATTTTGATTATCCTATATAAACAAAAAAACACCATATTCTTTTTAACTCCCCAGCTTT
+ATAACATGTTGCGTCTATATTTCTTAATACAAATCATTTAATAGTCTTGTAATCTGGCTT
+CTCGTTACAATGCTTGTAATCAAAAATCCCACCATTTCCACTTCCGTATATCTTGTTTTT
+CTAACGAAACATACAAAAGTACAACGTTTTTTACAATTTTCTACATAAAAACAGAAAATA
+TATAATTCATTTACATAATTTTGCACTTTAATTTTTATTAAACAACAAATATTTTATTGA
+TAAATAAAACTAAACATTCACTAATATATCTATACGTGGTTTAATATATATAATAAACAA
+ACATTTCTGACTTTTATAAGGAGGTACTATGAAAGCAAACGTAGGCGATACTATACTATT
+TCAACGAAATAACTTAAAGATCACAGCATCTGTACTAAAACTATACACTGAATCGGTCTT
+AGTTGAAGTCACAGATGTAAGCGGTGGTACTTTTGAATTTGACCGAACAATTGTAAATCA
+TAAAAACTATAAAATTTTAAATGCAAATAAATAAAACAATACAATACAAAATAGCCCCTG
+CTTAACAGCGGAGGCTATTTTGTATAATAACAATTCATTAATTTACATATCCTAAAACAC
+TAACAATCTTGCTTGCTTTTAAATTATTAATATAATAATAAATTTCTAACCCTCTTCTCT
+CAGCTCTTAGCACTTTACCTTTCATTTTTGATAAATGCTGCGAAACAGTCGATTGAGGAA
+TATTTAATATTTCTGTTAATTGTGTTACATTACAAGTTTTGCGTGCACTTAATTCATTTA
+CAATTTGTAATCGTATTGGATGCGCCATTATTTTTAAAATATCCACATCTTCTTCAGTTA
+CTAAACTTTTTTTTATCTCGCTCGTATATGTTGTCATAAGACATTCCCCTTTTATTTGAA
+TTCCTTTTTATTAAAATCTGCTTCTAAATAAAATATTATCTCTAAATATACAATTAAGAC
+CCTTATATAGAAATAATAGGATTTTGATTATTTAAAAACAGCAATACTATACAATTTCAT
+CTATTTGGTACATATACATAATACAATTTCAATTTGTGCTCTATGTGAAGTTAGCATAAA
+TTTATAATGAAGATTTTTCAAACAATTCACATCTAACTATATACTTCCTCATAACACTAT
+CCAGTGATTTTAACATATTTTAGGCGTTTGTATATACTATTGCAAAACACATTAATATTG
+AGGGGGACTTTATATGCCAACACCGTCACAAGAACAAGTTGAAGAAGCTCGTGAAACATA
+TGTCAGTCGTATTATTTTAGTTGGTGGTTCAGCTTTATTTTTAACAGGTGGTGTTATATC
+TGCAATTTCAGCCTTTAAAAGTTATAATCGTTTGGCAAATACGCCACCTTCTTCAAATGA
+TTCATAATTGCATCATTCATTCCTTTAAATAATAAAGATGCCGCCTCTACTATAGAGACG
+GCTTTATATAAAAACATTATTAAATTCATTTGAACTTAATTGAAAAAACGTTATAACAAT
+TTGGTACAATGTTCAAAGTAAGGATAGATACTTTCAATTTGACAAGCTTATTTCACCACA
+AACCTCGTCTGACTACACCCATCCTTCTGCTTCGTTACTTCTAATACAGCTGGCATTGCA
+TTTTTCAGTTCTTGAACGTGTGAAATTACACCGATAAAGCGACCTGATTTTTGCAAGTCG
+ATTAGGGCGTCAACTGCTTTCGTTAATGACTCTTCATCTAATGAGCCGAATCCTTCATCG
+ATAAACATCGTTTCGATGGAAATACCACCCTCATACGCTTGAATTACATCTGCCATTCCA
+AGTGCTAAGCAAAGTGATGCGTTAAATTTCTCACCGCCAGATAATGTTTTTACATCTCGG
+GTTTGACCTGTATATGCATCATATACATCTAATCCTAATCCACTTTGTCGATTCCTCTTT
+TCAACTCGTTCGCTTCGTTTTAAATAAAATTGTCCATTTGATAATTTACGTAGTCGTTCG
+TTCGCAATTTGAACAATTTGTTCTAAATACTCAATTAAGATGTAACGTTCAAAGGATATA
+CGACTATCGTTATCCCCTTTCATTACTTCATATAAATCAACAAGTTCTTGGAATGCTTTT
+TCTTCCTCATGAATTTGTTCATCAATTCGTTTAATATTTTCATGTAAATCCGTAATATAT
+GATACGGCGTTTTGAGCACGTTGTCGTTTTTCTTTAATAATATCAAGGCTAATTTCCAAT
+TCTTTCACTTGCTCATCTAATGAAGAAATGTCCATATACTCTTTATCTTTTAAGTCTGCT
+TTTAATTCTTCAATTTGTTTTGTAAGTACTTCTAGAGATGAGTAATAACTTTGGATTTCT
+TGTTGTAACTTATCCATCTCAGCATCATTTAATTTGGATTCTTTATATGTTAATTGATCT
+GTAAATCCGCTTTGTTCTAGCTCTTTCATAAAGCGTGTGAACGTCTCTTCTTTCTTCTCT
+TTTGCACTATTAAATTGATTAGAAGCATTATCATGTTCTGCTTGAATACGTATATTTTCA
+TTTTGCCAATGTTGATACGCCTCTTGTACTTTCTCCCATTCATCTTCCATTAACCTAAGT
+TCTTGCAGAGCTTGGTCAAACTGTACTTTCCAAGCTTGTACCGTTTGCAAGCTTTCCGGA
+ATATTTTGCTTATCATGTTCATATGACGTACGAAGCTGCATACACTCCATTTCAGTACGG
+TGCTGCACAGTTTCTACTTCACGCTTTTGTTTCTGGAGTTCTTCTACTTTTTCTTCTACG
+CTTTTTATATTCACAGCAATTTGCTTACGCGTTTCTTCACTTGCTTTTAACGCATTAACT
+TCTGCTGCTAATTGCTTTCCTTTTTGAACGAGCGCACTATATGTTTCTACTAATTCTTCT
+GAGCGATAGCCTCGCTTTAGCACTTCTTCTATCACTTGTTCATATTGAACTCGATAGAAA
+TTCCACTTTTCTTCTAATTGAACATGTAATTTTTCCGCAATAGTTTTCTTTTCTCTTAGC
+TCATTTAACTCTTTTTCATCAATTGCATTACTTTGCTCTGTAGCTTTTTTCGGGTGGTCC
+ATACTACCACATACTGGACAAGATTCACCATCATGTAAATGAAGAGCTAATATACCAGCT
+TGTTCACTTAACCAGCGGCGTTCCATATTTTCATATGTACTAACTGCCTGTTGCATCTTA
+TGAAACGCACTTTCTTTTTCTAGCTCGTATTTTTGTTTTTCTTGCCATACATCATATGCC
+TGCTTTAATACTTTTGCATCTTCTCGCATATTCGTTAGTTCTTCTACTTTAGCTACATAT
+TGTTCAAGCGCTGCTTCTAATTGCTGTAATTCGCCAGACATTCTTTGTTTTTCATTTTTA
+TACGCTTCTAGTTGTTCATCTAACTTTTGCATACCTTCTTTTAATTTTCCTATGTGAATT
+TCAGCATTTTGCAAATTTAACTTTTTCTCAGCTAATGATGCAATAATTGGCTGTAACTCT
+TCTAGTCTTTGAACTTGTTTTTTAGCATTTTCTCGCTCGGATGCCTTATTCTTTAATGCT
+TCATATTTCTCCTGAGCAAGTGCAAAACTGTTCATTATATGCTCTTTTTTTGCGATTATC
+TGTTTTAACAAACTTTCAGACTGCTGTTCATATTGCATCGCTTCCTCATGCCATTGCTCA
+AATGGTAATAATCGCTTCGCCTGTTCCGCATGTTTAAAAGATTTTTCTTTCATTTCGATT
+ACGGCACGGTTTTCTTGTAAAATACTGTACTTCTCATTCTTTTGTTCTAAATCTTTGAAT
+TTCTCATTTACAGCTTTTGCTGCATGAAAACGTGCCTCTGCTTCTTTTAATTGTTTCGTT
+TTGTCATTTTGTTCTAAGTGTAATTGCTCAACCTCTGCATTGTACCAATTTGTTTCTTGT
+TCTAATGCCTCTACTACTTGATGTGTATTTACATGCTCTTGCTCCACTAATGTCTCTAAT
+AATGCCCCATCACGTATTGGTAATTTAAATACATTACGGAAATATAGCTCACGTTCTTTT
+TGTTTTTCTTGTAAGACGTCTTTCCATTGTTTACGCTTTTGATCTAATATCTCACGCATT
+AATTTATAACGATCTGTTTTAAAAATGCGGCGTAGTATTTCTTCTTTATTTTCCGTTTCA
+GATGTTAATAATTTTCGGAACTCTCCTTGCGGTAACATGACAATTTGGCTAAATTGATGT
+TTACTTAATCCAATTAAATCTTCAACTTTTTTATTTACATCCGTTACATGAAAACGATCG
+ACACATGGAACTTTCTCCTCATCAATTACTTCATATAATTCGACTGCATGTCCTGTAATT
+GTTTTATTTCCTTGTTTTTTATGGCCCAGTTGTCGTTTAATTTCATAACTTTTTCCTTTT
+AATTGAAAAGTTAATTCCACACTTGTATAAACATCATCATCAGCAAATTGGCTACGAAGC
+ATGTTAGTATCACTGCGCTCTTCTCCACTAGCTTCTCCATATAATACATAACAAATTGCA
+TCAAAAATCGTTGTCTTTCCAGCTCCTGTATTTCCAGAAATAGCGAAAATACGATGCTCA
+CCAAGATCTTTAAAATCGATTACTTCTTTCTGTTTATATGGACCAAACGCGGTCATTATA
+AGCTGAATCGGTCTCATCCTCGCTCACCTTCCCGTTCTTGCACTGTTTGCAAAACATCTA
+AAAATAGACGTTCTTTCTCTTCTGGTAGATCTAGCCCTTTCATTTCTTTATAAAATGCTT
+TTAAAAGAGATAAATCATCCGTTTTATGTCTTGAAACAGTTACTTCATTTTCATCTGTGA
+ACTCTCGTCTTTGAATAGATCTTTCAACATGCATTGCATTTGGGTATACAGAACGTATTT
+TTTCCATTGGCTGCAAGACAGGATTTTCATCTAATAATTTCACAAATACATAATCTTCAC
+TCACTGGATGAAGCAATAAATCGTCTATTTTCGCTTCTACTGTACGCATTTTACGACGTG
+GTGTAAGTAAACGTTTTTCAATTGTTGTTTCACCTTTTTCATCCAGTTCCACAATATAAT
+ATCCTTTTTTATGCTTTTCTTCAGAAATAGAATATGCAAGTGGTGAACCTGAATAACGAA
+TTGTCTCATTACGTACAAAATGCGCTTGATGTAAATGGCCAAGCGCCGTGTAATGAAATT
+TATCAAAATAATGGCTATTTACATATTCAGCACCACCAATTGAAAGTGGTCGTTCCGCAT
+CACTCGTATTTTCCTCTGCCTCTCCTGAAGAAGTTACAAATGCATGTCCTACAAATATGT
+GTCTCGCTTCTTTATCCATCGTTTCAGAGAGTTCGTTCATAAAAATACGCATCGCATCAT
+CATGAGAACGAACATCTTCATTTTTCAATATATGTCTAACAATACTTGGATCTGCATACG
+GAACGAGATGGAAATGAACCTCTCCGTATTCATCATTTAAAACAACGGGATTGTATGGAA
+ACTGGAATTGTCCAACAATATGTAATCCTTGTTTTTTCATTAAATTACTACCAAAATGTA
+TGCGGTCCGGACTATCGTGGTTTCCTGCAACTGCGATTATTGGTGTTTGTAAATCAATAA
+CTATCTTTTGTAATACATCATTTAATAAGTCTACTGCTTCTGTAGGTGGAATTGCTCGGT
+CATATAAATCTCCTGCAATAATTACAGCATCCGGTTTTTCCTCTTCAACAGCTTGTACAA
+ACTGATCTAACACAATTTTTTGATCTTCAGTCATATATACACCATGAACAAGCTTACCTA
+AATGCCAATCCGCTGTATGAAAAAACTTCATATTACCCTTCTCCTTTTAGTTTACTGATT
+GTAGTGAAACAAGCTGATAGTTTAGTGTAGTTTTTCCGTTCTCCCATTCTAACTTTTGGA
+CAATTGCACTACCGATTCTTTCTTCGTTTGATTTATATAAAGGCAATATTTCTTGAATAG
+TAAATAGATGATAACCATCTAAAATTAATTGAAATAAATTATCTTCTATATGTAATCTTA
+CTTCTTTTTCATTTGAAATAATTTTTGTATGCATCTCAAATTTCATGCTAGATACAACCC
+CTTTTTTCTAATCTCTACATTTTAATAGTATAGTGGTCATGCAAGATTGACAAGTAAATA
+CACCGGGATGCACATACTTTTTTAATTATAAATATTTTATGTTTTTTTATATGAAATACG
+GTATGTGAAATTATTAATCTACAAAAATAAAAATGCCCTTTCAGGCATCCTTATTTTTGT
+AAGTACTCTTTCATAACGTAGTACAATACAGTTATTAAGACAATCGCTACAAAAAACGCA
+AATACGGCCACAACATACCCATCTTTATTTAATAAAAAGCATATGGAAATAGATATTATA
+AAAATCGGAAACACGAGACGTACCTTAGCCTTCACTTCTTCTGTCGTATCTGTATGATGA
+AAATACTGTGTAATTCCTACCATAAGAGATGACAAAATAATAACCGACAATAGTAAAGGT
+CCTGGCATTCCGATCTCTCCTTTCTCTATTTCTAATTATATACAAACCCCGCGCTCTTTA
+AAAGTTAGATAATTCAGCCTTTTAACTTTTTCTACATCCACTCTTTAATTTACACCACGT
+ATACTAACTCAATATAAGTTATACATATAATAGCGCCTTCAACACGACATTTTCAAATAA
+TAGCACTTACAGTAATGTTGTAATATTCCTCTTCATTCTCTGAAATCCTGCAAATATAAC
+TCGTCAAAATATGCGATAAGTACTAACACTAAGCACCTAATTTAGACAAAAATTATAGAG
+GACATTTCAGCATGTATCAAGAAATAAGAATAGAAAGATAAGTAAGGGAGGATTTATAAT
+GACTGAACACGTTTTATTTTCTGTTAGCGAAAACGGCGTTGCATCTATTACTTTAAACCG
+TCCAAAAGCACTTAATTCTTTATCCTATGACATGTTACAACCAATTGGGCAAAAACTTAA
+AGAATGGGAGCAAGATGAGCGTATTGAACTCATCGTTTTAAAAGGAGCTGGGACGAAAGG
+TTTTTGTGCAGGTGGTGATATTAAAACGCTATACGAAGCACGTTCTAACGAAGTTGCATT
+ACAACATGCAGAGCAGTTTTTTGAAGAAGAATATGAAATTGATACATTTATTTATCAATA
+CAAAAAACCAATTATCGCTTGTTTAGATGGAATTGTAATGGGCGGTGGTGTCGGTCTGAC
+AAATGGAGCGACGTATCGAATTGTAACAGAGCGTACGAAGTGGGCAATGCCTGAAATGAA
+CATCGGTTTCTTCCCGGATGTCGGTGCTGCTTATTTCTTAAATAAAGCGCCTGGATATAC
+TGGTCGATATGTTGCTTTAACGGCATCTATTTTAAAAGCTCCTGATGTATTATATATTAA
+CGCTGCTGATTACTTTATGACATCAGATTCATTACCAAATTTCCTTACCGCACTTGAAAA
+TGTAAATTGGAAAAAAGAAGATGTACATACTCATTTAAAAGAAGTTATTCGTACATTTGC
+AACTGCTCCAAACTTAGATGGCAATCTTTCTTCTTCAGTAGAAGAAATTAATTCGCATTT
+TGCATTCGATACAATTGAGGGAATCATTCAATCGTTAGAGAAAGATCAAAGTCCATTTGC
+CCAAACAACGAAAGAAAAGCTATTATCCAAATCCCCTGTTTCATTAAAGGTAACATTAAA
+ACAGTTTATTGATGGCCAAGAAAAGTCAGTTGAAGAATGTTTCGCGACAGATCTTATACT
+CGCTAAAAACTTCATGCGACATGAAGATTTCTTTGAAGGAGTACGCTCCGTTGTAGTTGA
+TAAAGACCAAAATCCAAATTATAAATATAAACAATTAAGTGATGTTTCAGAAGAAGATGT
+AAATCGATTCTTTAACTTACTTAACGCTTAAGCAAAGAGGCCATATATTGTAGCACACTC
+TCAGCTACTCTATATGGCCTCTTCTTTTTAGTTAAATAATTTTAAATATAATTTAATTTT
+ATTTAACTAAAATGTATGTTAAACTAACGTTAATCGAATTTTCTAAAAACAAAAAAGGAA
+GGCGGATAACATTATGGAAGATTTTTTTCTGTTTATTATTATGTCTATATGTCTTATTAT
+TCTACCCGGTCCTGATACAGCAATGGCTACGAAAAACACATTGATTGCCGGCAAAATCGG
+CGGCGTAAAAACTGTTTTTGGTACTTGTGTTGCGCTTTTAATTCACACTTTAGCTGCTGT
+AATTGGTCTTTCAGCACTTATTGTAAAGTCTGCTCTTTTATTTTCTATTTTTAAATATGT
+TGGTGCTGTATATTTAGTCTATATTGGTATTAAAGCCCTTTTAGCAGTAAGAAACACAGA
+AGACTTAAATACAAATGACGTTCCAATAAATAATGACAATAAACATACTTCTTGCTTTCG
+CCAAGGGTTTCTTACAAATTTACTAAACCCTAAGATTGCAGTCTTCTTTTTAACTTTTTT
+ACCACAGTTTTTAAATCCAAATCATAATACATTTATACAACTTCTCGTTATGGGACTTAC
+TTATCTCATTTTAACCGTCATTTGGTTTGCTTTTTATATATTTTTAATTGATAAAATTAG
+TGCTTTTATGAAAAAACCGAAGACACAGCGTTATATTCAAGGGATTACAGGAATCGTCTT
+AATTGGGTTTGGTATTAAATTAGCCTTTGAAAGAAATAGTTAACACAATACAAACGAAAA
+TACACTACTCGATTATGAGTAGTGTATTTTCGTTTGTATTATTTTTATAATGAGTGGGAA
+TGCACCCCACTCATTATCATTTCACTTTATTAAAACCAGCGCTCAGTTACAACTTTTTTA
+CGTGTATAAAATTGAACGCCATCCGTACCATTTGTACCAAGATCTCCAAAGAATGAAGCT
+TTGTTTCCTGCAAATGCGAAGAATGCCATTGGTGCTGGAACATTAACGTTTACACCAATC
+ATACCAGCATCAATATTGTCTCGGAATGTTTGTGCATGTTTTCCATTTGATGTATAAATA
+ACAGCACCATTCGCAAATTTCGATTGATTTGTCAGCTTAATACCTTCTTCTAAATCTTTT
+ACTCTTACAATACTTAATACCGGAGCGAAAATTTCATCTTGCCAAATTTTCATTTCTTGA
+TTTACACCATCAAAGATTGTTGCACCAACAAAGTAACCTTCTCCAACTTCTTCATTGATT
+TTACGGCCATCTACTAGTAAAGTTGCTCCATCTGCTACACCACTATTAATATAGCCTAAA
+ACACGTTCTTTATGAGATTCACGGATTAATGGTCCAACATAATTATCTTCGTTGAAACCG
+TCACCTACTTTTAACTTCTTCGTTTCCGCTACTAATACATCAATGAATTCATCAGCAATT
+TCATCAACTACTGCTACTACTGAACATGCCATGCAGCGCTCTCCACTACTTGCGAACGCA
+GACCCAATTACACCTTGTACTGTTTTCTCAAGGTTGCAATCTGGCATAACAACCGCATGG
+TTTTTCGCACCTGCTAACGCTTGTACACGTTTACCATTTTTTGTACCAGTTTCATATACG
+TAGCGTGCCACTGGCTCAGAGCCAACAAACGAAACTGCTTGAATATCTTTATTTTCTAAA
+ATACTATTTACAACATCTTTTCCGCCTTGTACTAAATTTAATACCCCTTTTGGAAAACCA
+GCTTCATAGAATAGCTCTACAAGTCGCTCAGCTAAAAGTGGCGTTCTTTCAGATGTTTTT
+AATACGAATGTATTACCGCAAGCAATTGCAAGTGGGAACATCCATAATGGAATCATCATC
+GGGAAGTTAAACGGTGTAATACCAGCAACAACTCCGATTGGGTAGCGCCAAATCGATCCA
+TCAATTCCACTAGCAATATTCGGAAGGGCTTGTCCCATCATTAAATTTGGTGCTGATGTT
+GCAAGTTCTACCGCTTCAATACCACGCTGTACTTCACCAGTTGCATCCGTTAGCGTTTTA
+CCGTTTTCTAGCGTAATGATTTTTGCAAGCTCTTCTTTATTTTCTTGTAACAGTTGTAGA
+TATTTGTATAGTTGTCTTGAACGATTTGGAACTGGCACTTTAGACCATGTTTTGTATGCC
+GCTTTTGCCGCTTCAACAGCTTTTTCAACATCTTCTTTTGGAGAAAGTGGAACGTAAGCG
+ATGATTTTTCCGGTTGCCGGATTCGGAACCGCTTCTACTTCCGTACCAGTAGATTCTACC
+CATTCGCCATTAATATGATTTTTCACTCGTTTAATTTCAGTTGTAATCATTATATTCTCT
+CCTTTTTTATCATGGTTTTTATAAGTGCACTATTTTTGATTAGAAATTAATTGTTCGCTA
+ACTTTCTTATATAAAGCAGCCATATCGTTTTCACCATATCCTGCCTCACTCGCTTCTTCA
+TATACGTTTAATAGCATCTCACTTACTGGTAAGTGAAGTTCGCTTTCTTTCGCTAAATCT
+ACCGCAAATCCTAAATCTTTCTTTAATAAATTCACAGTAAAGCCTGGCTCATAATTTTCT
+GATGCAATGAAACTTTTATAATTACGCTCATAAATTCTACTTTGACCGTAACTTACATTT
+AAAATTTCAAACATTTTATCTAAATCCATATTGTTCTTTTTCGCTAATGTTAAAGCTTCA
+CTCACACCAGCTGTATAAAAACCAATTAATAGATTATTAATTAATTTAACAGTTGTACCA
+CTATCAATCTGCTCACTAACATGGAAAACATTCGCTCCAAGCACTTCCATGACAGATTCA
+GTTTTCTCATACACTTCTTTCGATCCACCAACCATAAACGTTAATGTACGGTTTTCTGCA
+CCAATTACCCCACCGCTAACAGGTGCTGCTAAAAAGTCTACTTTCTTTTCCTTCGCCGAT
+TCCTCTAATTGTTTGTTTAATTGTGGAGATACTGTACTTGTATCAATTAAAGCTACATTC
+GAGTGGCTATTTTCAAATAATCCTTCTTCCCCAAAATATACCGCTTCAACAGCACGAGGT
+GATGGTAAGCTTGTAAAAATCACATCGCATGTCTCTGCTAGTTTTGAGATTGATAGGCCG
+ATAATTCCTCCTTCTTTTTCAAAGGAAGCTTCCGCCTCTTTATTCAAGTCCACTCCATAT
+ACTGTGTAGCTAGATTTAACTAAATTTTTAGACATTGGAAGACCCATGTTACCTAAACCG
+ATAAAACCAATCTTTTTCATATCGCTTTCCTCCTATTTACACAATATATTTCCCGCGATT
+TATAATAACTTTCGCAATATCTCTCTTTTTCGTAAATAAGTTTGAGTATAAAGGCACTAA
+TAATTGACGGATTTCAGCTAATATTTCTTGTCTATTTTGTTCTTCTGTGACAGCTGCTGA
+AAGAATGGAAATCGCGGATTCTTCTACTTTACGATATCCTTCTTCACAAATAACATCTGT
+TATCATTTGTTTCGTACGCTCTTTTTCCTCACCATTTTTACTAACTGCTTTCCTCGTACG
+TAAAAATGCTGATTCCATGACGTACACGTCCGTCAACATATTTGATAATACGCGTGAATA
+TTCTTGCTCTTGCTCAATTTTTAAACCTGGAGTTTTAGAGAGCGTTTTCAAAGATTGTTT
+CAACAATTTTTTCGCTAATAAAATGTAACGATGGTTTCTTTCTACATTTGCCACATCAAT
+TTCTACTTCAGCATCTTCTATTTGCTCGATTTGCTTCATTAACATTTTTGCAACTGTTAA
+TCTATTAATTTCATTCGTTCCTTCAAAAATACGACTAATCCTAGCATCACGATATAATCG
+TTCTACTTCGTATTCTTGCATATAACCGTAACCACCATGAATTTGTACAGCTTCATCTAC
+GATATAAGCAAGTGTTTCAGAAGCGTTTACTTTATTCAGTGCACATTCAATTGCAAATTG
+GGACATTTTTTTCATAAGATCTTCATCACTCTCATGAATTGCTTCATCAATTACACCCGC
+TGTACGGTAAGCTGCACTTTCTGCTCCATATGTAGAAATAATCATATTGGCAATTTTCTC
+TTGAATCATCGTAAAATCTACTAATTCCGTTTGGAACTGTTTTCGCTCTTTTCCATATTG
+AACCGATAAACCAATTGCTTGTTTTGCTGTTCCAATATTTCCAAAAGCCAGTTTTAGTCT
+AGCAAAGTTAAGGATATTAAGAGCTACGTGATGCCCTTTCCCAACTTCCCCTAAAACATT
+TTCAGCAGGGATGACAACATCTTCTAAAATAAGCGTCGCTGTTGAAGAACCTTTAATCCC
+CATTTTCTTTTCTTCTAGTCCAATGGATACACCTTCACATGTTCTTTCGACAATAAACGC
+TGTCATTCCTTTATTTGTCTTCGCAAAAACAACGTATACATCTGCCATATGAGCATTTGT
+AATCCACTGCTTCTCACCATTTAACTTCCAAGCAGTTCCATCTTCATTCAATACTGCACT
+CGTTTTTGCACTTAATGCATCAGAACCAGCATTTGGCTCAGTTAAAGCATAAGCCCCAAT
+CCATTCTCCAGACGCAATTTTCGGCAAATATTTTTCTTTCTGTTCTTTCGTTCCATAATA
+TATGTAAGGCAACGTACCTACACCGGCGTGTATATTAAAAGAAACGCTAAATGCACCAGC
+GTAACCCATTTTCTCTGCTACAAGACCTGAGACAGCCTTTCCTAACTCGAATCCGCCATA
+ATCTTCTGGTACCTCAATGCCTAATAATCCAAGTTCCCCAGCTTTCTCAAATAATTGACG
+AGAAACTTTATAGTTATGTTGTTCAATATTCTCAATTTGCGGGACAATTTCTTGTTTAAC
+GAATTGTTCTGTCGTTTTTGCAATTAAATCTTCATCCCCTGAAAAATCTTCTGGTGTAAA
+GAAAGTATTATTCACATCTTTATTGAGTGAAAAAAATTCATCCCATGGTAACTTCGTTTT
+CTCCATCTGAATCCCCCTATCATTTCGGCCTTCGTTGATTTTTGCATATGCTCGTCTACG
+ATGAGTGGAATATCTTATTATTGAAAACAGAAGGCGATGATTTTTCACATCAAGCAGTTC
+GTTTTGCCAAAGATGTATTTTCATCGCCTAAATCCTTCTACCTATTGATCTTCAGATAAT
+ACTGTTTTTGCAATTCCAGTATCTAACTCTTCAAAGTCATGATATGAAATTGTTTCATAT
+AATTCACTTCTCGTTTGCATATTAGAAAGTGCATCTTTTTGAGAACCCGTTTCCTTAATT
+AGCGTGAACACATTCTCATATGCTTTTGCAGCAACACGAAGTGAAGTTACAGGATAAATT
+ACCATTTGGAAGCCCATATTCGCAAATTCCTCTGCACTATAATATGGTGTTTTTCCGAAC
+TCAGTCATATTTGCTAGTAAAGGTGCATTCACTTTGCTAGTAAATAAACGGAATTCTTCT
+TCCGATTGAAGCGCTTCTGGGAATATTGCATCTGCCCCTGCTTTTACATATGCATTCGCT
+CTTTCAATCGCTGCATCTAATCCTTCCACGCCGCGAGCATCTGTGCGTGCTACAATATAT
+AAACTTGGCGCAACTTCTTTAATCGCTTTAATTTTTTGAACTAATTCTTCTGTAGTAACA
+AGTTTCTTACCATTTAAATGTCCACATTTCTTTGGTAATTGTTGATCTTCAATCTGAACA
+GCCGCAACTTTCGCTTCCACCATTTCTACAGCTGTCCTCGCTACGTTTAGTACTCCACCA
+AATCCTGTATCAATATCAACAAGAACTGGTAAATCTGTAGCTCTAACTAGATCCCTTGCT
+CTCTCTGCTACTTCAGTAGACGTCACGATTCCTAAATCTGGTAGTCCTTTACTTGCAGTG
+TAAGCAGCTCCCGATAAATATAGAGCTGAAAAACCTGTGTTTTTCGCAACAAGAGCCGCC
+ATTGCATCATGAGCACCTGGAATTTGCAAAATTTCATTTGCTTCTACTAAAGCTCGGAAG
+CGATTCGCAAGCTCCTCTTGTGTTGACTGTTTATTCACAACCCAAGCCATTCTAAATTCC
+CCCTATTATTAAATTAAGAATAGATCTACAAATTCGTTTACATTCATATTTTCTAGTTTT
+TCTTCATTTAGACAAGCATCATGGATTTTTTCTTGTTGCTTACTAGAATAATGACCTGCC
+ATATTTGCAGTGAATTTTCGAACAACTTTTGGAATTGCTTCGTCTCTACGGAAACGGTGG
+CCAAGTGGGTATTCACATTCCACATTTTCTGTTACAGTACCATCTTTAAAATGAACTTGA
+ACAGCGTTGGCGATTGAGCGCTTGTTCGGGTCAAGGTAATCTAAACTGTACTGTTTGTTT
+TCAACAACAACCATCTTATTACGTAATTCATCTACACGTGGATCATTCGCTACTACATCC
+TCATAATCATCCGCAACGATATCTCCTTTTAATAAACCTATTGCCGTAATGTATTGTAGG
+CAGTGATCGCGATCAGCTGGGTTATTTAATGGACCTTCTTTATCGATAATACGAATTGCT
+GACTCATGAGTTGTAATTGTAATACGATCAATTTCATCTAATCTTTCTTTAAGTTCCGGA
+TGTAATTTCACTGCACATTCTGCAGCTGTTTGTGCATGGAATTCTGCTGGGAATGACACT
+TTGAATAATACATTTTCCATTACATAAGATTCTAGCGGTCTTGCTAATTTTAATTCTTGC
+TTGTTAAATAACACATCTTGGAATCCCCATCCTGGTGCAGATAATGCCGTTGGGTAACCC
+ATTTCACCTTTTAATGCAGTCATTGCAAGATGAACACCGCGGCTCGTCGCATCACCTGCT
+GCCCATGATTTACGTGAACCTGTATTTGGAGCATGACGATATGTACGAAGACTAGAATTA
+TCAATCCACGCATGTGATAATGCATTAAAGATTTCCTCACGCGTTCCGCCAAGCATTTTT
+GCAACTACTGCAGTCGTCGCTACTTTTACGTATAATACGTGATCAAGACCAACACGGTTT
+AAACTGTTTTCTAAAGCAAGTACACCTTGAATTTCATGTGCTTTAATCATCATTTCTAGT
+ACTTCACGTACTTTTAATGGTTCTTTTCCTTCTGAAATACGAACGCGGCTAATATAATCT
+GCAACTGCTAAAATTCCGCCTAAGTTATCCGATGGATGTCCCCACTCTGCTGCAAGCCAA
+GTATCGTTATAGTCTAACCAACGGATCATACATCCGATATTAAATGCGCCTTTTACTGGA
+TCTAGCACATAAGATGTTCCTGGTACACGTGTACCATTTGGCACGATTGTTCCTGGTACA
+ACTGGTCCTAATAATTTCGTACACTCTGGGTATTGTAGTGCTAAAATTCCACATCCAAGT
+GTATCAAGTAATACGTAGCGAGCCGTACTGAATGCCTCTGCACTTGTAACCTCTTTATTT
+AATACATAGTCCGTAATTTCTTCTAATAATGCATCTTTTTGTTTAATTTCATTTGTTTTA
+ATCATGCTATTCTTCCCTTTCTGTCGAAAATTCGTTATTATTAATGATGGGTGTCGGTCA
+AACACCCATCTGGCGGGCGGCGCTAACAACTCCCCAGTTGTTTTTATTTACTAAATGCAT
+GTCGCTCGCCAATATAATTTACACGTGGACGGAACAAACGATTGTTCGCATGTTGCTCAA
+TTACGTGTGCACATAGCCCTACTGTTCTAGAACTAAAGAAGATTGGTGTGTAAAGTTGAA
+TTGGAATACCAAGCATCCAATATACTGGAGCAGCATAATAATCAAGATTCGGATAAATTC
+CTTTTTCCTTCTCCATAATTTTTTCTCCAGCTTCACACATTTCATATAGTGTATAATCGC
+CTTTCACATCACATAACTGCTTTAATGCTTCCTTCATCATAAGTGCTCTTGGATCCATCT
+TTTTCATATAAACACGGTGTCCAAAGCCCATAATTTTTTCTTTGTTATATAGTTTCTTCT
+GTAATAACTCTTCAAATTTCTCAACATTACCAGCTTCTAAAAGCATGTACATAACCGCTT
+CATTCGCACCGCCATGAAGACTTCCTTTTAAGGATGCAACTGCTCCTGTTAAAGCGCCGT
+ATAAGTCGGATTGCGTTGATGCAATAACGCGTGCTGTAAATGTAGAGTTTGGCATTTCAT
+GTTCACTATATAAAACAAGGGAACGATCAAAGATTTTCTCTTCAAGTTCAGTTGGTTTCT
+TTCCAGTTAACATATAGAAGAAATTCGCACTATATGACAATTCTTGAAGAGGCTCAATTG
+GTTCCTCATTATTTAAAATATGGTAGCTATTCGCTACAATATTTGGCACTTTACTTAAAA
+GCTTGTATCCTCGACTTTTATTCACTTCTAACGAGCGGTTTTCGATATCACTATCGTAAC
+CAGCTAATGCAGACACACCTGTACGTAGCCCATCCATAGGATGCGTTTCCTTAGGCAATG
+CCTTTAGAACATTGAATACACCTTCTGGCACTGCATATTCTTCTTTTAATTTCTTTTCAA
+TTGTTGCTTTCTCATCCTCATTCGGTAAACGTTCTTCTAATAAAAGGTGCACAATGTCTA
+AATACTCTTTTGTTTTTGAGAGTTCGATTAAATCATACCCTTGAATTACAATTTCACCTT
+TTACTGTGTCAAGAAACGAAATTTTCGTTTCCGCTGCTACTACACCATCTAATCCCGGGG
+AAAATTTTTCTTCAGCTTTCATCATTATTTCCTCCAATCCTAATAGATCTTCGTGCACAT
+AACTGTAAGCCTTTACAATAATATGAAACTACATTTCTATTTCAATGTATCAGAGTTTTT
+AGAAGATTTCAATTTATTTTATAATGATAAGTTTCCTATACTTTTACCGATGTAATAATA
+CAATTTTTCAAAAATAACTTTCATCTTTTATAAAGAAAGGACAGACATCCTTTTACAATG
+TTTTAAAACGAAATATAACAATTATCCATATAATCCCACTAAATATACCTTTAATCCCTT
+TTTCTTCAACAAACATAAAAAACCGAGCTGCACTCATGCACAGCTCGGTTTTTTATAATA
+TTTATTTCATATTCCCATAAATATAATTCTTATATAAAATTTATTTATTTTTAATAAAAT
+TATTATTTTACATAATTAAATTAAATTTCTTCCGTTTCTTTACGATAGCTTACAACTAAT
+TCATAGTTTTGAAAGTACGAAAGATCATCAAAATCTATAAAAATAAACTACCGTCTTTCT
+CAACTGACACTATTTCCCGAACTGATTTCTCAGAAACAATCCCTAAAGAATATCCGGGCT
+GAATTGAGCTATTTCCTCCGTACCTTACAATACATCAAATAGATTCATCATGCTTTATAC
+GCAAAATCTTTTTTGCCTAATCGTTGTTTTACAAAAATGACAAATATAATTAAAGCTATT
+AATCCTGAAATTGCACTACCTGCAAATAAAATACGGTAACCAAACATTTGTGAAACTACT
+CCAAGTAAAATCGCACCTAATCCAATCCCTAAATCAAAAGCGGTAAAGAATGAAGCGTTA
+GCAACTCCTCTTTTACTAGGATCAACAATTGTCAGCATCGCTGCTTGTAAAGCGGGCTGT
+GCTGAACCGAATCCAACACCATATAATGCCGCTGCAATCATTACACCTATCAAACCATTT
+GAAATCGTTAGTACAACTATCGCTAAAATAGTAATACATAGTGCCGGAAGTATGATAAAA
+ACTTCTCCATACTTATCTAATAGTTTTCCTGAAATAGGTCGTACAATTGTTAAAGCAATT
+GCATATACAAGAAAGAATGTCCCAGGATTCACATCAATTGATGACGCGAATAACGGTAAA
+AATGTTGTTATTCCTCCATATGCAAATGATAAAAAGAAAACAACAACCGTTATTGATAAA
+ACGGATTTTTCAAACAGCTGAATTTTCCCTTTTTCTTTTTGTGGCGTGAATGGCATTTTC
+GTTATTAACGATAATACGACTGCCATAAAGGATAAAAGAGTTGCTAACAAGAATAGACCA
+TGAAATGAATAATTTTGTACAACCCATAATCCAATCATCGGGCCAATTGCCATCGCGATT
+GTCATCGCCATGCCATACCAGCCCATCCCTTCACCACGACGTGAATCTGGAATAATATCA
+GTTATCGCTGTTCCAACTGCTGTTGTAGAAACAGCCCACGTCACTCCGTGAATAACGCGT
+AAAACAGCTAAAAGGACAATAGTCGATGCTAAATTATACGAATACATCGTTATCCCAAAA
+AATATGAGTCCGAAAATAATAAAAGATCTTCTACCATATTGATCTAGCATACCTCCAATA
+ATCGGTCGTATTACAACTGCCGCTATTGTAAACATTCCCATCATCAGTCCAACTTGCGAT
+TCATTTCCACCAATCTCTTTAATAAAGAGCGGGAGCGTTGGAACAAGTAAATAAAACCCC
+GTAAATAAAAATAACATCGCGATAGTCATTTGTATAAATGATTTCGTCCATAATCGTTCC
+ATTAAAATCCCTCCATAAACACGTAAAATATTACAATCAACACATCAATTGTATATTTTT
+CATGTTCCCTTGCCCTCCGCTAATAGACGTATCTTTTCATAATAAATGGTCTACCATCAA
+TTTAAGTTGGTCTTACGACTTTATGCCTATGTTTTAAGCAAAAAACCTATATATGTACCT
+TTATATGTTTTAGAAGAATATACTATTTTATTATTAAACTTAGGAGTGATCGTTTTCATG
+TGGGTATCACCAAGAATAACCGCCGTTGTCCCATCAGCTCCCTCAATACATGTTCCTGTC
+GTTCATACAGCTAGTTCTGATGTTGGTATCGAACTTCCTGCCGCTTGGCAACAATATCAA
+TCGACTGACCAAGTCACCCCTTCATTTTGGCATCATGGTACACACCCGAGTAGTACTACT
+TTTTATGGCCCTAGTTATCCAATACCGCCAACTCAAATTTTTTATCATTTCCCATCAATT
+TACTTTCAAAATTTCTATGGTACTTTTAATATTTAAAAATAATATTACTCTTTATAATAC
+AAAAAGCACCAAAGAAACCGTTTTTCCCGGTACCTTCGGTGCTATTAAAATGCATTATTT
+ATTGTCCATTATTGGAAGGAGCCTCTCCTGTGTTCCCGCCAGTAGTTGGTGGATTTGGAG
+TTCCTTGGCCACCTCCAGTGGTTGGTGGATTTGGAGTTCCTTGGCCACCTCCAGTGGTTG
+GTGGATTTGGAGTTCCTTGACCATTTCCATTGTTTTGTTCATTTTGCTTATTCTGTTCAT
+CTTGTTTCTTTTGCTCTTCTTGCTTCTTAAGTTCATCTTGTTTCTTTTGCTCTTCTTGTT
+TCTTTTGCTCTTCTTGTTTCTTAAGTTCTTCCTGTTTCTTTAATTCCTCTTGATTTTTCT
+CTTCTTCAGTTTTTTGCTGTTGATCTTGTTTTGGTTGTTCCGTTGTATCCGGTACGCTCG
+TATTTGGAGATGAATCACGTTTTTCACCTTTTATACGCAATTCACTACCTTCTTGAATAA
+CACTACTTGGCATTTTAAAGCGTGATTTATCTGTAGCCATCTCGCTCATCATTTCTTTAA
+AGATCAACTGTGCAATTTTCGTATTTTTACTACTAATATACTCGTCTTTACCATCTTTCG
+TATATCCAGTCCATACTGCCATCGTATATTGCGGTGTATATCCTGCAAACCAACTATCAC
+GAGTTGCACTTTCTGGAATTCCATATTGTGCTAGTTGTTTTGAAGAATAGTTAGTTGTAC
+CTGTTTTACCAGCTACATCTAAAGAGGCCACATTTGCCGATGTACCAGTACCTGATGTAA
+CTACAGAACGAAGCATATCAGTAATCATATATGCTGTAGAATCCGCCATAACTGATTTTG
+GTTTTTGTCCAAAACTTTGTGACTTGCCGTCTGGATAAACTACTTTCTTAACAAAATGCG
+GCTTCGTATACTTACCGTCATTCCCAAATGCCGCATAAGCACCTGCAATTTCAGTTGGTG
+ACGCTTCATTTGTACCGATCGCTGTTGATTCTGTCGGTGCTACATTAAATGTAATACCTA
+ATTTCTCAGAGAACTCTTTCGATTTACTAATACCTACCTCTTTAGCTGTTTTAATAGCTG
+GGATATTACGTGACTTTGTTAGTGCTTCACGCATTGAGATTGGCCCTAAATGACTTCTAT
+CTGCATTTCTAACTTCTTGGCCAGTTGAATACTTAAATGGAGAGTCATCAATTTGATGAT
+AAGTAGCCCATTTTAAATATTCAATTGCAGGAGCGTAATCAAAAATTGGTTTCATCGTTG
+AACCAGCTGCACGATCTAATTCAATCGCCATATTATGCCCTTTAAATACTGCTTTATTTT
+CACCGCGCCCACTACCTATAGCGCGAACTTCTCCAGTTTTCGTATCCATAAATGTGAAAG
+CACCTTGGAATTTATCATTTGGATAATTAATAATATTTGTATTCAAAATATTATCAGCTA
+ATTTCTGTGCTTTCGGGTCTAATGTTGTATAGATTTCTAAACCATCTGATCCAATATTAA
+CATCTGGTATTTCCTTTTCTACTTCTTTCACAACTGCATCCATAAATGCAGTATGAGGCA
+TTGCTTGAACAGTTGCAGTCTTAAGTCCATCTGTTACTTTAACTTTCGAAGCTTCTTCCA
+TTTCTGCCTTTGTAATATAACCATGTCTATTCATTAAGTTTAGTACAGTATTTCTTCTTT
+CTGTTGCCCTTTGAACATTTTCTTTTTTCGTTGGGTCATAGTTATTCGGTGCTTTTGGTA
+AGCCAGCTAGCATCGCAACTTCTGGTAATGTTAAATCTTTCAATTCTTTACCGTAGTAGT
+TTTGTGCTGCTGTTGCGATTCCATATGAACGGTTTCCTAAATTAATTTTATTTAAATACA
+TCTCTAATATTTCATGTTTTGAATATTGTTGTTCTAGCTTATACGCTAAATATATTTCCT
+GAACTTTACGTTTTGACGTTTTTTCCATCGATAAGAAGTAGTTTTTAATAACTTGCTGCG
+TTATCGTACTACCACCTTGAGAGCCATAATCTCCCTTAAGACTAACTAAAACTGCACGAG
+CAGTACCTTTAAAATCTACTCCGCTATGCTCATAAAAACGCGAATCTTCTGTTGCTAAAA
+ATGCATTTTCTACCAATTTAGGGATTTGATCATACGTAACATTCGTCCGCTTTTCTTTCC
+CATATTCATATACCAAATTCCCGTCTTTATCATAGATTTTTGAGGATAACGGATTAACAA
+GTTTTGCTTTCTCAAGTTTTGGTGCATCCTTAATCATTACGAAAAAGGTAGCAACCCCTG
+CCACTAAACCTACAATACCAAGTAGTAAACAACTGATTAAAAATTTACGAAAAAACGATG
+TTTTACCTTTTGGTTTTGTTTTTTTAGAAGCTGGCTGTTTTTTCTTTTGAACTTGTCGTC
+GCTCCTCTCGAGAACGATAATTTTCTGACATGTTACTTTCTCCTGCCTTTCAATTCTCCC
+GTTGATTTACTTGAAAATATTGAGGTCACTTTCCCAAATACATTTAATCAAGAAAGTATA
+TTGACCTGGAGCATTCAATATTTTCCCAATTCACAGATTATACATTTTAGAATACTTCTT
+ATACAAACTATTTTCACTTCTATTTTTTCTAATAATACTGCCCCTTAAAGCATAGAATGT
+AAGAAGTGAATTTTTAATACCTCGTATAAATAATATACCTTTTTTTCAAATGGTCAATAT
+TTTCTTATTTATAAATCAAAGGTGAAATAAAAATAGCACAACGATATGTACTTCGTGTGA
+ACTTCCTTATAATTACGTATAACAAACATTTAATATATTGCATATAAGTATAATACTCCT
+TTAATTATTAGGATTTCAACACGACAATCCCCTTCTCTACAAGAAACCATCTAAAATGAA
+AAATAAGGAGTTGCGTAATGATGGAGCTATCTCCCGTTATTTCAAAAAAATTAGTTGCTG
+TTGGCTATAATCCTTTTTCTATGATTTTACGTATTCAACTAAAGAATGGTATGTATGATT
+TCTTTAATGTGCCAGAAAGCATTTACACCGGTTTATTAAACGCACATTCTAAAAGTTATT
+ATCATAATACTTATATTAAAAATTCTTACCGCTATACTAAAATTTAAACTTGATTGGCAT
+ACAAAAAAGAAAGGCGAATCAAATCCCCTTTCTTTTTTGTATGTCAATCGCAATTTACCT
+TCTATTTCTTTTATTAATTTCATCATACGCCTGAACTTGTTTTTTAAGTCGCCTGTCGGC
+TTTTTTATCATGTACGACAAGAACTGCGTGTATCGCTCCTGGAACCCAAAAAATTAAGGT
+TAAAATGAAATTAATAATCGCTTGAAACGGCTTTCCGCAAAATAAAACAGCTACCGGCGG
+AAGTAGAATTGCTAATAAGTACATCATGTCTGAAAAACTCCTTAATGTTTATTTTTCGAT
+TCTTCCCCATCCATCTCCTACACTATCAAACCTATGAAATCATGTTATTTCTAAAAGTGT
+ATATAAGAACTCATCATTACAAAAATCACATATAATAGTATAACTAAATGAGGAACCTCT
+CACTAACGTTAACAAGTTATTTTCACCTGTTCGTTTATATGTATATTCTACGCCTATATG
+AAAAAGCCTACAAAAACAATTAACACATCCATCTTGTCCTACTTCTAAAATTGAAATACT
+CCAAACTTCATTGAAATGAGTATTTCATCACCTTTTCTTAGATTCCAATCGTTGTTCCTC
+TACTATTTCGGTTAATCCAATTGCTGAAATTACAGTACCTATTGCCTGTATCCAAATACC
+TATTAGCCCTATTATACGTTGATCTTCTTTATCTATATTACTGTCTTCTTTTCCCTTTTC
+TTCTTTTGGTATATTTTTAATACCTTCATATGCTTGTAATCCCGCACCTAAACTTTGCAT
+TGAATTCCCTAATACGATAATCCACTGTATTCCATTTATCTCATTCAATGCTACTTCTAC
+TCCTAAAAAAGCGCCAATTGATTGCAAACTATTTCCAGTAATTATAAGGAAATCATTTTC
+TTTCATTTGTTCATTGAGATTAAAATACGTTCCTATTACATTTGAAATATTACCTAAAGC
+TAATAACTCAATCCCCGTTTTCGCTAGCGCTTTATTTTTATTATCTATAGTTACCTCTTG
+CTTCTCACATTTATCTTCATCTTTCGCATCATTAGTTGCTATAATTTGTAATATATATCC
+GAGAGCTTGTAATGAACTCCCTACAATAACGAGATCCGACTCAATCTTTTCTTCCCCTGC
+AAACCCTCTAGTTGTTCCAATTGCTGCTATAAGATTTCCTCCTACTTGAAACCAGGCACC
+TGTCAATTCTAAATCGCGTAGGTTCATTTCCCATCACCTATATTTAAATTTTCTAGTACA
+TTCAAAACAAACAAATATCACCTTTAATTCATTATTCTATTTTTCATATGTAATTTTGTG
+CATCACATAATGTACTAATAATACAAAAGAGCACCTTTCAGGCGCTCTTTTTGACAAGGA
+GTTTCTCAATGAATGTATGCCGGACATGTCAATGACTCACCGTTTTTATCTATTGATATA
+TTTAATATATAATGAATTGCTTTATGTGACCACATTTCAGGTGTAGGAGATTCTTTTACA
+TATTGAGGTGCACATAAGTGAAGCATTGGAGTGCTAATACTGCCACCTGGATCTAAAGCA
+ACTACTGCCATACCATTTGGCAGTTCCATTGCCATTGACTGCGTGATACCTTCAACAGCA
+AACTTCGAGGCACAATATGGCGCAAGTTCAGCCTCGCCTTCTCTTCCCCAACTAGAGCTC
+ATGTTAATAATAATTCCTTCTTTCCTAGCTATCATCGCCGGGACGAACGCCCTAATGACA
+TTTACTACCCCGTTCACATTTACACTCATTACACTTTCAAATTCTTGTGCGGTAACTTTC
+CATAGAGGTGCATTTTGATTAACAATCGATGCATTATTTATTAACATATCGGGAGCCCTA
+TACTTATTAAGAATACGACTTGCCCATTTACTAACTTGGTGATGATTTGAAACATCAATT
+ATTTGAAAATCATGTGAAGCACCGTAATATTTATTAAGTTCTTCAATTTTATTTTTTGAG
+CGTCCACACCCTGCTATGTTCCACCCCAATTCATGAAACCTATCAACCATTGCACGTCCT
+AACCCTTGCGTTACTCCAGTAATAATTACAAGTTTCCCAATGTCGTTTCGCTCCAACTTC
+ATCTCCTCCTTTCCATTAATATTACTCTTTTTATTCTTATTCAACTTCTCACTTAAGTAT
+CAATTCATTTCATACTTTAGAAGTATTTTTGATATTACATATTACAAACAAAAAGAGTAA
+CCATCATAGTTACTCTTTTTGTTTGTATCATTATTATTTTTAAATTGTATCTTCTATTCC
+CTACATTTCTCACATCGATAAATATAGGTTACACCTTAATGAAAGTATATTTATGTTTAC
+GGTTCGATTTATCCAAATACTTTTCAATCCACTTTTTCAACTTAACAGAGCCCACCTCTA
+TCAATAAATTTCCACCTAGTCTTATAACATACTTTTATTTAAATTCTCAATCTCATTTTG
+CAACTTTTTAAAATTCAGCTCTTCATTAATTTTAACATACTTTTTGCTCGATTGATTAAA
+CAAAGCTTCAAACATTTTTCTATTCCGGAATATTTGTCAAATGAACCAATTAGACTATAC
+CTTCATATAGTAATGCAAACAATTACTTATAAAGCAGGTGAAAATTATGCCCTCAGTTGT
+TGGGAATTTAGTTGTACAAAATAGTAACGGATCTTTCAACTTAGGTGATTTCTACAATGT
+TTCTCCAAAAGAGAATACGAAAGCTTATAACGGCTCTGGCGCATCTAACGTTGGTTTCGT
+AGTGAACACTTTTAGTGGGGTTAGCGCGACTAATACATTTGATTCTGATCTAGCAGATCA
+AAACCAAGTTGGTACGGCCTAACCAGATCTGTAATCATTTTTGTATAACATTTTAAAATT
+TGTCTATACTATACTCAGGCTGATACACAGCTATCATTGATTTTTTGAGTGCCAATCTTT
+TTCTCCCTTTCCCTGGGACTAAGCAGCTAGCTTGCAGCTAGCTGCTTTTTCATTTAGTTC
+TTCACCTCTTCAAAAAATTAGGTTTTAACAGGTAGCCTGACTCACAGCCTAATTTTGAGG
+TGTGAATCTGCCTGTCCGTAAATAGCTAGATAAATTAAAGAAGCTAAACTTCAAAATTCA
+GCTTCTTTTAGGTTACATCAATTATGTCCATTGCAGAAAATATATATGTTTTATAAAATG
+CATCTGTACATTTTACAATTTGTTGAATTGGATTTATATGAACCACTGTCATATAACTCG
+TAAGTATGTATCCTTCTTCAAAATATATCACTAACATCTCTTCTTCAGACAATAATGAAG
+TTAATAATTTGTCTGAAATGCTGTCTTTCGCTTCATTTGTTATTAGCGGTCTTTGGACTT
+TTAATTTCTCTCCAATAATTTTTTTCATACTTAATAATTGTTCCGACATTACTGTAAACG
+GAACCCACTCTCTTCCTTTTTCCTGTATCTTTACATAATTCATTTTCTTTACTCCTCAAT
+TTTCTATATCTATCCATTCTTGAACTACCCCACTTTCACTTCGTTTAGAAGTGGGGGATT
+CCTAAGTAAAGAGTTCTATCGAACTCTAATTTATTAGGCTATCTCCGCAGCCCTTGCGGT
+TAGAAGCCTTATCGCTTCATTCTTTATCCATCTCTTATTTATACGTAGCGTAGCTTTCCA
+ATTCAAAACTATTTATGAATTTGTAGACATCTCCACTTCAAAAGAACATTCGTTCTAATT
+ATACACGAACGAACGTTCTTACGGAAGTGCAACATGTAAATTTTTCAAACAAAATGCAAC
+TTTAATATATGAAGTTTATTCATACTCATTTATTACTCCCTTTTATTAATCAAATTTCTT
+TGCACTTCCTATCGCATCATAGAATACGTGTAGCAACAATAAAAGCGACTCCACCTAATG
+TGAAGTCGCTTTTATTGAACTAATTATATTTCTAATTTTACTTTTCTATCCTAACTAACG
+TTCTTTCTGTAATACAAATTTCAGCTACATCTCATTAACCATCCTTCAACAAAAGCATAC
+ACTTTTATTATGAACGAACTCACAAAGCTTTAGAAACTTATGATGTAAAACAATTCATTC
+CTCATAAGTTTCATACATATCGACAATTACTACCATTTATCCTGCTATTTGCAGGCAGTA
+AGATTCACACTCATCAATTTTTCACTTTCTTTATTGAATATGCTTGGGTTGCATTATAAT
+ATGTAATTCTCTCTCTGTTTCTGTTTTTTTCGGATTCCGATAATATTCCAGTTTATATTC
+TAATACTTCATACTCAACCATCCCAATCTTTATCCCTTTTGTTTCTTTTAATACAGCTAA
+TAGAACGCTTATATTTTCATTAGATGATTCAAAAATTTTCCCTCCGCCTTCTCTCTTAAA
+AATAACTTTCATATATTCTCCCCAAAATTAATTTAATAATCTAGTAAATATAAAAATATT
+CATCCTATTTTAATAAAGTGAAGGCTAATAATCAGTGGGGGTTTTACGAGCAGTAAGACT
+CCCACAAATAGCGGGATAAATAATTCTTATCATCATTAAGAACATCTTTTTGTACTAAAT
+GTTCAACATGTCACTTCCTATAAAGTTAATTTATACTCCAATAAATATGATATGTACCAT
+TCTTTAAATTATGTCCTCAATTCACTCTCCAAGAAAATATATTTAGTTTATATTTAACAA
+AATTAATTAACTAAAACATTATCATTTCAACATTTTGCGAATTTAATTGCTTATTCCTTT
+TATCTACATCCAAATTTTCCTATTGTAATTCTTAATATTTAAATGTAATATTGTATTGTC
+TTACTATCTATTTATAACTCACACACTAACGCGAAAACAAAAAAAACAGAAATATAGCAT
+TATGCTAAATCTCTGTTTTTCTTCTAAACCTTATTTCTCATCTAAGAATTTAAATGTATC
+TTTAAATTCTTTATCTGTTACTTTAATATCTGCTTCTTTCAATAGATCATTGATTACTTG
+TTGTTTCCATTTACCTGTCGCATCTTGCAGTCTTTGTTGTTCTAAATCTTTTCGAATCGT
+ATCTTTTACTTCATCAAATGGTTTCAATTCTTTTTTATCCGTCACTTTTATTATATGATA
+ACCATAAGATGTTTTTATTGGCTCACTTACTTGTCCTGCATCTAATTTATACGCAGCTTC
+CTCAAACTCTTTCACAGTTTGACCAGGAGCAAAACCAGCGATTTCTCCGCCCTGTTCCTT
+TGAACCAGTATCTTCCGAATACTGTTTCGCTAAAGCAGTAAAATCTTCACCATTATTTAT
+TTTCTCTTTTACTTCTTTCGCAGTTTTTTCATCTTTCACTAAAATGTGACTTACCTTCAT
+TTCAGGTTTATGGTTATCTTTCACATCTTTATCTGTGACAGTCGCTCTAATCGCTTTCTC
+AAGTGCAATTTCTGGCTTCATTCTCTCTTTTAATTCATCTTCATTCTTTAATCCTACTTG
+CTCTAAAGCGACTTTAAACTTGTCACCCATTTGTTCCTTCGCTGCTTCTACTTGTTTTTT
+AGCTTCTTCATCTGAAACTTTATATTTATCTAGCAATGCCTTATTTAACATCATTTGAGA
+TAAAGTACTTTTTCCATATGTTTGCCTTAATTCTTTACTTAACTCTTTCTCTGTCACGTT
+TCCTACTTTTGATGTTGCAACATTTTCTGAGGAACCACACGCAGACAATGTTAGCGCCAC
+ACATGCAATAATAGTTCCCATAAATAGCTTTTTCTTTTTCAATTCAAATACCTCACTTTG
+ATAAATGTATATTAGGAACTATACAGCGCTATTGTGAAATCAATGTGTTTTCTGCAAGTA
+TTTCTCTTCATGCCAGAGACAAGCTTTATTAAATAAAAAAGCCGGCATAAATCCGACTTT
+TAACATCATTTAATCTGCACATGTTCTTCTTTGATCCATTTGTTCCCACCTATATCTATA
+TATCCATCTTGACGATTCCAAATACGATAAGGAACCCTCCCATCGACCGCACCTGTATCA
+TTCCCGTTTGGCCCATCGTACGTTCTAATTTCATATCCAGGTGTATACTTTGAATATGCA
+TAAAACCATTGTACATTAAAATGTTCTAACTTAGCCCACTGTTGTTCACCACCTAAACAA
+ATCATATCTTTTTCGCCACCTCCCCAATAACCTTTATAGATTAAATATGGGATTTTTTTC
+GTAAGTCTTCCTATAAATTGTGGATTCGCAGGATTTTCATATAAATTAATTCCGTATCCA
+TCATCATATTTTGAAACTGCAATACCAATTCCATTTGGTCGCTTACTGTCTCCAATACTA
+GATTGATTTGTTTGATTTGAACCTATAAACCAAGAAAGATTTTTATTCCCAATTAATTGA
+TTCAAATCACATTTTCCAATACCAGGAACATTTCCTGAATCAGTATATTGCCAAATATCA
+CAAGGATATGCTGGTTTATTCCCTCCATAACGAGGAATCCAAATAAAATCAGCATCAATA
+TTGCGAGCTCCAAATGATACATACGTGTGATGTCCTACATATAAACCAATTTTTTTTGCA
+CCTAATCGGCGTAATTCATCAATAAATGCTTGAGTCCCGCCTTGCATATCTATCATTGTT
+TGAACTTCTACATCTGCCACCCAAAATTTAGCGTTTTTATCGCCACGATTCCAAAAATCT
+TGTGCTTCTTTTTTTGCATCTGAAATAGATATAAAACGGCAAAATGCATAATTCCCAAAT
+GGGATACTACGTTTCTTCATTTCTTTCACATAACCTTGATACATAAAATCGATCGTATTC
+GAACCATCTTGAACTCTAGCAATAACTAAATCTAGCTGAGACGCTGCAATATCCCAATTA
+ATATTTCCATTCCATTTCGAAATATCTACAATATAACCCATTACTAATCAACTCCTTTTT
+ATTATCTTATTCAAAGCTTGTTTTATTGCTAGACCCATACGCCTAATAGCAAGCTTCTAT
+AAGACAAATAAATATATTTTCATCATTTTTTAAAACTAAATAATTTCTTTTTATCCATAA
+TAAATAAGTCCTTCTTTTTTTGCATTTGTAAACGATAAACTTGCGTTTATTTCATACTAA
+ATATTGGAATAAAACTATAAATAATGTACATACTACATATAAGCAATTTTTGCTTATACT
+CATGAATGACCTCCAAGATTTTTCAATCTCCCTGTAAAAAGGCAGCTAAAAAAAGCTGCC
+TTTTTACAATTTATTATATAGAGACAAGTTAATTAACGCTTATTCCCTCATATTAGTCTG
+TTTTTAAGCTTTTTATAAACATGATATATATTTTTTCACAACACTATTTTGATACGTAAT
+AGAAATTACATCAACTCATACAGTATATGTAATAATCAACTACAATAAAAATTACATATT
+ATATTAATATGTCTTCCTAATTAAAAGGAAATAAACATATAACCTCTGTTATGTAAGGAG
+TTTATTTAATGAAAAAAATCCCTATCGTATTCAAAGTTCCCCCGAATTCAAAGCTAAAAG
+TTACATTCTATGGTCCTTGTAACGAAGTAATTACAAATGTATCTTTAATTAATCAACTAC
+TCACCACTACCTGCCAAACTGTATCTCAATATCCAGACTTCAAGAAATATATAACTGAAG
+TCCGATCATTATCAAATTGTTAATCGTATAATTTTATGATTTATCATTTCGAATAGTACG
+ATAACAAAATAATAAAAAGAGCCGCATCTTTCAAAAGAAACGGCTCTTTTTCATTTCACA
+AAACATGACTTCATTAAAAAACTAAAATAACTCATTAATTGATATTCTGTTGATATTTTA
+TTGATATTTTACACATATTAATGAAATGCGCATATATTATCGTATGGAGATTCTCCACTC
+ATAAAACCTATCTTTTTTTGAGCATACTTTATTTGTATGCTCCTTTTTTATTCTTTACTT
+AACGGCTTACCCTGTTAATATTTCCAAATATCATCTGAACGAACATTGAATATTTCAATC
+TTTTCTTATTATGTGCTATGAATATAAGTTTAATAATTTATCTGTAGCTACATTTTCAGT
+ATCACTTAAATCGACAAAATAATGAAGTTGCCACAATTGACTCTTCTTAGCTTGATTACT
+AATAGGTTTATCCCAAATAGGGTAAACCCTCATAGCCATTTTCCCTTTTTGATTTTGAGT
+TTTTAATATTTTTTCTTTTAGAAGAATCTCTTTTGGAAAAATAAATTGTCCTAGGTTATT
+ATCCGCTATACAAGTGATAACTAAAAGGTTCGGAGCTGAATCATAAGAAAATGCCTGATT
+GCTCATGGAGGCATTCTTCTCCCAAAAAGAAACAAATTGTCCAATCTTATTAGGCGTAAT
+TTTTGATACCCTAAATCGGATGCTTCTATTATTTAGCTGGAATACCCCTCCTGCATATTC
+TGAATTTTGCTTTTCTTCTTTTCGTTTAGTAATTAATAGATTATTAGGTTTGTAAATCAT
+TTCATCTAGTTTTTCAATTATATTACTAAAATTTGTCATGTAAACGCACCTTTTTTATTT
+TCCAGTATACCAAGAACGTTCGTTCTTGTATATTAAACTTAAACAAATGTTGGCTTTGAA
+TAGTCTTTCAAAGATTATTTTATCTACTCCATCCATAACTTCAAATTTACTTTTATAGTA
+TTTATTACATTACTCTTCCAATTCCTTATATTCTTCATTATTTCATTAATATATTAATAA
+AAAACGAGGTACATATTACATGAATCCATCCAAAATTGACTTCGGCTCCATAGAGCAACC
+TTTATTCCTATTAATTTTATATCTTATCGCAATTCTTTTAACACTCGGCATTACATTTAG
+TATATGTCATTCCCTTTTACTAAATTTAAATGCACCGAGATGGGTAGCAAAACTGTTAGC
+TATCATATTAACTCTAGGTGTTGCTTATCAAGTGTTTATGAACTTATTTTAATATATTAC
+CAATTTAACACCTTTAACTAAAAGGCCCTACCATAAGGTAGAGCCTTTTTCAAAAAAATA
+GTCCATAAATCACAAACATGTCTTTTATTTTATTGGAGATGGGAATCTTGCAGCTTCAAA
+ATGCGTACTAATAAATCCTGGATCATTTTGTATAATCAGTCCATCTACATCACTCTCAGC
+AAAAATTTCAACTACATCTCCTGCATGTAATTGAAGTATTGTTGAAACAGCTACGACATT
+TGCAAAATTGGGTGGACCAAAAAAGTCATTATCTATCGCTATAGCTGGATTATCATTTAC
+CCGAATTTCTACACGCGCTCTATAATTCGTATTACTATCATTAGGTGCAAAGCTGATTGT
+ACCAATAATAGAATAAACCCCTCTAGTCTTCGGAATAAAATCTGATGTTACTGGATTATA
+TTCATTCGCTAAATCAAACTGTTCATTTTGGAATAATACTTTAACAAAAGTATTTGCAGT
+GACATTTTGATTTACTGTACTAACCGCTCTAAAAGCAGATGCCCTTACAAGTTTATCTTT
+CTCATTATCACAACACTTATCGTAATAATCTGTACTCTTCTTACAACAAGTATGCTTTGT
+CTTTTTATAGCCATTGCAATGCTTACAATAATAATAAGC
+>NODE_15_length_39993_cov_62.9495_ID_29
+TCTTGATTATTGGCGATAAAGTCCCAAAAAGTATCGTGTGCTGTTTGTCCTTGGGGAATC
+TCATTATGTGGCTCTGGTTTAAGAGCATGAATAAGATCCGGAAATTTAATACCATCTTGA
+ATGAAGAAAATCGGAATGTTATTACCCACTAAATCGAAATTTCCTTCCTCTGTATAAAAC
+TTAACAGCGAATCCTCGTACATCTCGGTTCGTTTCATTTGCACCTTTTGATCCAGCAACT
+TCAGAAAAACGAATAAAAATAGGTGTCTTTTTAGATGGGTCTTGTAAAAAATGAGCCATT
+GTTAAGTCTTCTAAAGAATCATATAGCTCAAAAACACCATGTGCTCCGTAACCGCGGGCA
+TGAACGACTCTTTCAGGAATTCGTTCACGGTCAAAATGAGCGAGTTTTTCTCGCATCAGG
+AAATCTTCTAAAAGTGTAGGACCACGATCGCCGGCGGTTAAAGAGTTTTCATCATTTGAA
+ATTTTGACACCCGTATTCGTTGTCATCTCTTTTCCTTCATTGTTTTTCGTAAAGGATTGT
+AACTGTTCTATCTTCTTATTTTCACGACCGTCCATATAAAGCACCTCCCATATTATACGT
+ATTATTGTTCATGGTTTTTATGCTTACATATGGTATGGGGAAGTATATTATCTATGGATT
+GATTTTCCTCATTTGTTCAATTTATCTTTGTTTGTCTATGAAAATCATTTATTATAATAA
+ATGGTATTCTTTTGAAGGGGTGTTGAAGTGGAAGAGAGTTTTCTATCAGCTAAAGAAGAA
+AAGAAAAACGCTAAGATTTTCTTATGGGTAATACATGTTATTTTAATTGTATACGAGGTT
+GCATACGCGATTATATTAGAAGATACAATGCCTTTAGCAAATTGGCATAAAGGGATATGG
+AAGCTTGCATATATTATGGCTATATTAGGTATTAGTGTTTACTTATTTGAGAGAGAAAAA
+GCATATTTAGTTAAATATACATATTTATTTGCATACATGATCGCAGAGACTTTTAATATT
+GGATGGTATGCTTTTCATAATACAATAGCATTTGATGAAGGGAATGTAATTGAATATATT
+TTCATTTTCTTCGTACCGATCTTTTTGAGTAAAAGATATTTATTTGTCTTAGCGCCATTC
+CTTATAGGGAAATATATGATATACCTATTTGTATTTGGAGAACTTAACCTGTTTATGTCT
+CTTGTTATAAATATGGTGTTACTTTTCGTGTCATTTATTATTTTAAATCGATTTTTACAA
+TATCTTTCAGCAGTAAAGGGACGTATTGCAGAGGCAAGTCATTCACAAAAATTGGCGGTT
+ATCGGAAAAATGGCAGCGACAGTCGGACATGAAATTAAAAACCCACTTGCTTCATTAAAA
+GGGTTTACGCAATTACAAAAAGAGAAACACGAAAAAGATGCAACATATGAACAAATGATT
+CTCGAAATCGAAAATATGAATAATATGATTAGTGAATTAATGGAGGTTGCTGCATGTAAA
+CCTTCTGTTTATGAAAAACACATTGTAAGTGATGTTTTAGTACAAGCGGTAGAAAACATG
+CGCGGAAAAATGAACGAGTTAAATATAAATTGTACCTTTAATGAAGAGCAAAATAGAAGC
+GAAATTGAATGTGATAAACGCAAATTAAAAGGAGTATTTTTGTATGTTATTAAAAATGCT
+TTAGAGGCAATGGAACATGGCGGAACATTAAAAATACAAGTTGAAAATAAAAAAAGAGAT
+TATGTAATAGTAAGTATAGTAGATAGTGGTTTTGGGATAAAAAAGGATAATTTAGGACGA
+GTTAAGGATGCTTTTTATACAACGAAGCAAGATAGAATTGGATTAGGTCTTACGGTAGCA
+GAGCGAATTGTGACAGAGCACCTTGGAGAATTACACATTTCTAGTGAAGTAAAGAAAGGA
+ACGAGAGTAGAAATACTGCTCCCGAAAAAATGTGAGCGCAATGTGACACAAGATTAAGAG
+GTGTTGTTAAAGGAGCTATCATATGGAAAAAGGAAATATATTTGAAAAAGAAGAGATAAA
+GGCATTAATAATATTTTTAAGCTTATTCTTCGTTATATTTTTTGCGTATGATTTTGCTGA
+AAAAGCTATTGTCCTTTTATCAGATAAAAATCAAAAACTAGCAGATGCTTTTGGAGAAGG
+ATTAGGTTTATGGCTATATAGTTTTATGGTTGGATTATTCTTTATAGGACTTTATTTTAT
+GAAATGGAAAAAGCCGTATATTGTGAAGTATATTATTTTAATTGGCTATAATATATTGGA
+TTTTATTAATAACTTCATTATTTATTACGGAAGTGATGCGGAATTTGATGGCGGGAATAT
+AGTAGAAGGATTCTTTATTTTATTTGCACCAATATTTGTGAATAAGAGGTACTTTTGGTT
+AGTTGCGGGAACTATTGTTGGAAAATATGCACTTATGGGATTCGTTGTTCAATCCTTTAT
+TGTTCTTATCCCAATAGCATTATATAGCGTGTTTGTTATTATATGTTGGATTATATTTTT
+AAGATTCCAATCTTACGTTCGTACACTTGAAATGATGGATAAAGAAATACGAAATGTAGA
+GAAATTAGCAATGGTTGGAAAAATGGCGACAGTAATTGGCGATAAGATTAGAAGACCGTT
+AGAAAAATTGAAAAAACTTGTGAATAAGCAAGCGAAAAAATATCCAGAAGATAAAATTTA
+TAGTGAAATTATGAGACAGGAAGTAGAGCGAATTCATACAATTGCTACAGAACTAAATGG
+GTTTGAGAAATCTAAATCGGTAGAATCCGAAACGTATAATATTAAAGAAATCATCTCTTA
+TGTTATCAGGGTTATGGAAAAGCCAGCTTTAGAACAAGGAATAAAAATGCATGCTATTTA
+TAGTAAAGATATACCATCAATTACATGTGAGGAAAAACGATTGAAACAAGTATTTTTTAA
+TTTAATAAAAAATGCGATTGAAGCAATGTCAGTTGGCGGAACTATTACTGTAAAAGTTAT
+AGTGGAAGATGTGATCATTGTTCAAATTATAGATGAGGGATGCGGCATTCCGAAAGATAA
+AATTCCGAAGCTAAATGAAGCTTTTTACACAACGAAAGAAACTGGAACAGGCTTAGGATT
+AGTAGTTACGGAAAAAATTATTAAAGATCACCACGGTAAATTGAACTTTGAAAGTGAAGT
+TGGAGTTGGAACGACTGTTGAGATTATGTTGCCGATTTAATTATAGTGGGATATTTTAAA
+AAGGGGAAATCACTTTCTTTAGAGTGATTTCCCTTTTCAGTGTGGAAGGAAGTACGGAAT
+TTTAATAAACGGGATGTTTACAACATTGACAAACTGTACAAATTCACAATCCAAAATATG
+GGTGTTTTAAAGCGAGAGTATATAATAAATTTGTCTGTTATTTGTTTTAATTTATTTGCA
+ATTTTTTTGGCCTCGGCATCGAGGTCCTTTTTGTAAATGAATGATTTGTAAGTGTGGATT
+ATATATCAGTGATTAGAAAAATAGAATATACAGAACTTGCCGTAATCCCGGGGGTAATAT
+AAAGAGATATCGCATCCCCCCTCGAAAACAGGTTTCCGGTTGTAATACTAGTCCAAGTTA
+CAGTGGCAGGTCCAGGTGCTGGAGTAGGGTTATACACTTGAGGTTGTCTAGAGCCAATAT
+CCGTAGGTTTAATTGAAAATGTCATAGTTCCCGTAATTTTATCTGTAGTAGTTAAAGTAA
+TAGTAGATAGGATGTAACTAGAGGTAGGGGCAGAGAGGTTTGTTGGGACATTCCTGCAAA
+TATCAATCGTATAAACAGCAGCGGGTAAGTTATTAATATTTATAGATGTAGCAAAACCAA
+CTATATTTCCAGCTCCAGCAGTTACATACGGAATAACGTTAGAATCAATTCCTGGAGAAC
+CTGCTATACGTTGAAACCCAGCATTCGTCCCTTGAAAAACAATACTTTTCGCTGTTGAAC
+TACCAGCAGGTCCAGTAGTCCCGGTAGAACCAGTGGCACCAATAGTTCCGGTAGCTCCGG
+TAGAACCAGTGACTCCAGTAGAACCAGTAGCTCCGGTAGAACCAGTGACTCCAGTAGAAC
+CAGAAGCTCCGGTAGAACCAGTGACTCCAATAGTCCCGGTAGCTCCGGTAGAACCAGTGA
+CTCCGGTAGAACCAGTAGAACCAGTAGTTCCGGTAGAACCAGTAGAACCACCTTCTACCA
+ATACGATATAATCTTGAGACACATTCGGAAATCCTTGAGGTGCATCTTTTTTTACAACAT
+AGCCGCTACTCGTGTAAGTGACAACTTGTCCCGTTTTATAGTTAGGAGCGGCTGCTAGAC
+TAAAAGCGGTAGTACTTTGCAAACCGGCCCCGGCATTGCCAGTAGGTCCAGTAGCACCAG
+TGGGTCCAGTAGCACCGATAGAACCGCTGTTGCGTCTACCGTCACAACTAAAGCAATTGC
+GTTGGTACATATATTATCTCCTTTCTATATTTTTGAAAATCTAGTTTTAAAAGTAGAACT
+ACTATATATATATTGTAGATTCTATATTTTTGTGTGGTCGATCGTATTGTGTATATAGAT
+TTTAAAAATAGGGGAGGTGTTATTAGTTTTATAACCACCAGGTCTCCTGCGGAATCAAAG
+TAACATCTACATCAAAATTCTCTTTAAACCAATCATACATCAATGTCTCTTTCACTAAAT
+ATTCAGAGGCAGAGTGTGACAAACCGATGAGTGACATATTTGTTTCTTTCGCATAATCCA
+TAATGAGTGAGTATTTATGCCTACCATAATCATTGTCGATATGGCAATGGATTTCTCCTG
+TAATAAATGATTAAGTTATTGTTCTATTTCTTTTAAGGCTGGCATGTTTGGTAATCCTCC
+TTAAGATAGTTCTTACTTTGTTAGTTGTTTTTGTTTTTTTATGGAAAAATAAGAAGCGGA
+TAGGAAACAAATAAAACCTAGAATCCAGCCAATAGAAGGAGAATAGGGAAGTATATGTTG
+TAATACCATTCCGCTAGAAATAAAAAAGCTACCTAATAGACCTAAGAAAATGAGATATCG
+CTGTAGTTTGAACATCAGTGATACAACCTCCTTTATCACGCATTAACTGCCCGTAACCTG
+ATTGGCGAGGGCTAATAATCAGAGGGGGATGGATACCTCCCTGATTAAAGTTTCACTTTA
+TCACATATATTTCAAAGTAGTCTTAATTTTCTGCATATAAGATTCGAGAAAAATGGTGGT
+ACAATATATAAATGATACGAGAAGAGAGGATGTAGGTTAACACATGTACGTTACTGTAAC
+AGAGGCAGCATATAAAAAGATTATGGATACGATTCCAAGTGAAACGAAATATATAAAGTT
+ATTTTATGATAATGAAGGTTGCGGTTGTGTTATGAGCGGGATTATCGATTTAGTAGCCGT
+TTCAGAGAAAGATGAGCGCGATGTAGATATCGAATCAAGCGTACTAAACTTTATTGCAGA
+TCGCACAAAGCTTGTATTTATGGATGATAAATTAACAGTTGATTGGCATGAAGTTGGAGG
+GACTTTCCAGCTGAAGAGCCCAAGCCAGTTTTATAATCCGAATATGAAGTTACATGTTCG
+AGTATAATGAAGAGAGAAGGAGTATATAATATGCTCCTTTTTCTTATGGATTTTTTCACA
+TAATGAAATGTACATATAGTTGAATTTTCTGTATAATTCTCTTTGCGAAGGGAGTTGCGC
+ATGAAAAGATGGGGAATTGAGTTATTAATTTTAAGTGTCGTTATTATTTGGGGGATTAAC
+TATACGATTGCGAAATATGGACTTTTAGAATTTACAGCAATTGAGTTTACTGCAGTTCGA
+ATGATGACAGCAGCACCACTACTGTTATTACTTACGTTCTTTATCGAAAAGTCACTTTAT
+ATGGAGCGAAAAGATATACCAAGATTAATCATCGTTAGCGTTGTAGGTATTGTACTGTAT
+CAAACGTTATTTATGGAAACTGTAAAATACACATCCGCTACAAATGCTTCTTTACTCATA
+TCTATTTCACCTATTTTTACAACTGTATTTGCGATTTTCTTGAAACAAGAAAAATTTTCT
+TCTCGAAAGTTAGTTGGTTCCATGATTGCCTTTATTGGTGCTACATTAGTTTTAGTAGCG
+GGGCATTCACTCGCTAGTTCTTTCTACGGAAATGGGATTGGACTTATTACATCAATATGT
+TGGGGACTTTACCCCGTTTTAGCAGGGCCGCTTATTAAAAAATACTCAGCATTACGTGTT
+ACTGCATGGTCGACATTAGTTGGAGCGATTCCGCTCTTATTGTTAAGTGGCCCACATGTA
+TTTGTCATGCCATTTCACATTACACACGGAATGACACTATTTGCTTTACTATATTCTGTT
+TTCTTTGTAACAGTATTCGGTTTAGTCATGTGGTATGTTGGTGTTCAAAAAATTGGTGCG
+TCACATACGATGGTATATATGTATATTACGCCGCTTGTAGCTGTTTTATTTGCAGCTGTA
+TGGGCAAATGAATATGTATCGTTTCAACAAATAATCGGTGGAATCATCATTTTCTTCGGT
+CTATGGTTTGTGAAATCAGAGAAAGTAGAAGCTAATTCTATCGTGCAAGAACCTATATCA
+AAATAGGAAAACAGATCACCTATGATCTGCTTTCCTATTTTTTTATTTTTGGTAAAAATA
+CGAGGAATAAAATGGCAGTAATAAGTGGGATTAAATTAAGAAAAGGAATGCGGAAGAGTG
+TAATAAGAATAATACCTGGAAGAAGAACACCGAGGACAGCATAGAAAATACTATGTTTTT
+TCGTGTACCAATACAAGGAAAGTCCAATAAGTGCAGGAACAATGAGATGAATGAGAGCCA
+TTAAAAAATAAATCATTAGACGCCCCCTTTATTTATGTGCTTATTACATCATATCCGTAT
+GTTCATAGATTGATATCAATTTTTTCATAATTGGACGGAAATGTTTTGAAAAACGTCACA
+TTTATGAGGGATTCTATATTAAAAATCTTGTATAATATTATTTCCTAAAAGCATTTTAAC
+AACATAAACATACCGTTTATGTTGTTTTTAATTTGAATGAAATAGATTTTAAGTAGTATG
+GACTCGAAAGAAATGAGTTATACAGCTTTTGTTGGATAAATAGAAAAAACATTGAAGGGG
+AGTACAGCATGATTAGTTTGTCATTAAAATCGTTTAAAGTTCAATCATATTATCTACTAG
+GTATTCTGTTATTAGGCTGGATGTTAACACCGTTTTCAGCACATTTTCTAGGTGCAGGAA
+TTGGACTTATTGTAAGCATGTATTGTGTTTGGATTTTAGGAAGGCGTATCGAAAAGCTTG
+GAGATAGTATAGTAAAGAAGACGAAAGCACCGACGCTTGGTATGTTTAATCGCTTTGCAG
+CTGCAATTTTGGGTGCTATTATCATGTACGAAATTGAGCATCATATGGTAATGTGGGCAT
+TTGCAATAGGTATTCTGGGTGGTTATTTCTTAATCGTTATTAATTTAGGGTATTATAGTA
+TGAAGGATGAGGAAGAATTAACGAAGGGCTGAAAAAGATAAAAAGATGAAAAGCCTCTTT
+TTAGATGGGATAGAGGATCCAGCGGTGGATAGAAGCCGTTAGGGCCTTTTTTAGCCACAT
+GCGGTGCGAAACCAGAGCGAGGTAGTGAGCAGGAATATAATTTATATGTTCGAAGCCGTA
+ATTTGTATATATGAAAATCTGGTTATTTAAATTGAAAATTGGCTTACTCTGGAATAAGGG
+ATCCGGCGATGGATAGTACAACAGGAAGCGTAACTTTGTATAAAATATAGGTTTCCGCTT
+CCAATAAGTTAATATGAAATCACTTAGTAGTATGACTCTTAGGTTCTTTAAAAAAGTTGG
+ATACAATACAACAAACTATTCCGGTAATTAGAATAATGTATTTTATCGTTTCACTTGTAT
+GCTCAAATAAATTAACGTTAAGCATTACAAGTCCCCAAAACATTTGAATCGCTCCATAAC
+TGAATAAAATTTTTTCTGTACGAGAAAAATTTTTCATGGGCCTCACCCTTTCCTTTATAT
+GTAAAATATATCATAGGAAACTACAAACGAATGATTATAAAATGAATTTTCTGTAAATTT
+ATAGGTATTGGTATGCAATAGATGAAGAGATTAAAGTTTCACTTTATATAAGATATAGAA
+AGAAGCTTACGTTTTTAACGTAAGCTTCTTTTTTATGTAAGTGTGTGTAACCGTTAAGCC
+GCATTGGGTTTTGTCGGTGAGTACGCGGAACTTTACGGTTACACGACACTTATTCATATG
+AGTAAAAGGGTTATTCCAACAGAAAATTTGTAATTAAGCGATTGGACCGCCTAAGTTAAT
+AATAGCTTCAGAAACGCTATCGAATTTTTTGAAGTTTTCTTTAAATTCGTTTGCAAGCTC
+AATTGCTTTCACTTTGTAAGCATCTTTATCAGCCCAAGTTTGTTCAGGCATTAATACTTC
+ATCAGGTACACCTGGAACATGACGAGGTACTTCAAGGCCAAAGATGTCGTGTTTTGCAGT
+TTCAGCTTTAGCAAGTTCACCGCTTAGTGCTGCTTGAATCATTGCACGAGTGTAACCTAA
+GTTCATACGTTTACCAACGCCGTATTCGCCACCAGTCCAGCCAGTGTTTACTAAGAATAC
+TTTCGCATCATGTTTCTCGATTTTTTCACCAAGCATTTCAGCATAACGAGATGCATCAAG
+CGGTAAGAACGGTGAACCGAAGCAAGTAGAGAATGTAGCTTGCGGAGATGTAACACCGCG
+CTCTGTTCCTGCTAGCTTACTAGTGTAACCGCTTAAGAAATGGTACATAGCTTGCTCTTT
+TGATAACTTACTGATTGGAGGCAATACGCCAGATGCATCAGCAGTTAAGAAAATAATTGT
+ATTTGGATGTCCTGCAACACTTGGCAGTACGATATTGTCAATCGCATGCATAGGGTATGC
+AGCACGTGTATTTTCTGTTAAAGTAGTATCGTTATAGTCAGCGATGCGTGTTTGACCATC
+AATGACAACGTTTTCTAAAACTGAACCAAATTTGATTGCATCGAAGATTTGTGGTTCTTT
+CTCATGAGAAAGGTTTACACATTTTGCATAGCAACCGCCTTCAATATTGAATACGCCGTT
+ATCAGACCAACCGTGCTCATCGTCACCGATTAATTTACGGTTTGGATCAGCAGATAATGT
+TGTTTTGCCTGTTCCAGATAAACCGAAGAATAGTGCTACGTCGCCTTCTTCGCCTACGTT
+TGAAGAGCAGTGCATAGAAAGAATGTCTTGTTCAGGTAGTAAGAAGTTCATAATAGAGAA
+GATTGATTTTTTCATTTCTCCAGCGTATTCTGTACCACCGATTAGTACGATACGTTTTTC
+GAATGAAACCATAATGAATGCTTCAGAATTTGTACCGTCAATTGCTGGATCTGCTTTGAA
+GTTTGGTGCAGAAACAATTGTGAACTCTGATTCGTGAGTTGCTAATTCTTCTTCATTTGG
+ACGAATAAATAATTGATGTACGAACAAATTATGCCATGCATATTCGTTAACAACTTGAAT
+TGGTAGGCGATAGTTGCGATCAGCGCCAGCAAATCCTTTGAAGATGAATAACTCTTCTTT
+TTCTTTTAAGTATTCTAAAACTTTTATATATAATTTATTAAAATGTTCTTCAGAGATCGG
+TTGGTTCACGGCTCCCCAAGCAATTTTGTCAGCAACCGATGCTTCCTTCACAATAAATTT
+ATCCTTAGGAGAACGTCCTGTGTATTTTCCTGTTGAAGCAGAAACGGCACCAGTAGAAGT
+TAATTTCCCTTCGTTTCGCATTAATACTTTTTCCACTAATTGCGGAACACTTAATTGAAT
+CTGTGCATTGCTTCCGTTCAATAATTCATGTAAACCAATTTGGACATTCACAGTACTCAT
+ATTTATATACCATCCTTTTCATTTAATGAAATATTTCTCGTAATCCCCATCAATAGTATA
+ACACAATTATATAAATAATGTATACTATTTATTTATTTTTGTTTGTGTGAATGTATCATT
+TCCCTATTAATATTTCATTCTATGGGTATTGAGAAAAACTTTCAGGAAAATGTGAATATT
+AATTGACAAATGAATATCATTTCTTTAGTATAGGTTGGGACGGATACTCTCTTATCCCGA
+GCTGGCGGAGGGACAGGCCCGATGAAGCCCAGCAACCTCATTTGTAGTGGTAAATACAGG
+TGAATAGGTGCTAAAACCTGTGCGAGGCTAACGGTCTCGAACGATAAGAGCAAAGGGCAA
+AAAGCAGTATGCAAGTAGCAAATTAAACCTTTCCTCTATGTTAAGTAGGAAAGGTTTTTC
+TGTATGCTTGTGTGGGAGAATAAATGTATGTCGCAGTTTGTGGCAAATTAAGGATGAGTT
+CCGTACAATATATACAATTACTGTAGGGAGGTTTACCACATGACAAAAAAACGTCATCTG
+TTCACATCTGAGTCTGTAACTGAAGGACATCCAGATAAAATTTGTGACCAAATTTCTGAT
+TCAATTTTAGATGCGATCTTAGCAAAGGACGCAAATGCACGTGTAGCTTGTGAAACAACT
+GTAACAACTGGTTTAGTATTGGTAGCGGGGGAAATTACGACTTCTACTTACGTAGATATT
+CCAAAAATCGTTCGTGAAACAATTCAAGGCATTGGTTACACACGCGCAAAATACGGATTC
+GATGCAGAAACTTGTGCAGTTTTAACATCTATCGATGAGCAATCTGCTGACATCGCTATG
+GGTGTTGACCAAGCACTAGAAGCACGCGAAGGTCAAATGACTGACGCTGAGATTGAGGCA
+ATTGGTGCGGGAGACCAAGGTTTAATGTTTGGCTTCGCATGTAATGAAACACAAGAATTA
+ATGCCACTTCCAATCTCGCTTGCTCACAAATTAGCTCGTCGTTTAACTGAAGTACGTAAA
+GATGACACATTATCATACTTACGTCCGGATGGAAAAACGCAAGTTACAGTTGAGTATGAT
+GAAAATGGTAAACCTGTACGTGTGGATACAATTGTAATTTCTACACAACATCATCCAGAT
+GTTACGTGGGAAGAAATCGATCGCGATTTAAAAGAGCACGTAATTAAAGCTGTAGTTCCA
+GCAGAATTAATGGATGGAGAAACGAAATTCTTCATTAACCCAACTGGCCGCTTCGTAATT
+GGTGGACCACAAGGTGATGCTGGTTTAACAGGACGTAAAATCATCGTTGATACTTACGGT
+GGATACGCTCGCCATGGCGGTGGTGCATTCTCTGGTAAAGATGCAACGAAAGTTGACCGT
+TCTGCAGCATATGCAGCTCGTTATGTTGCGAAAAACATCGTAGCAGCTGGTCTTGCTGAC
+AAAGCAGAAGTACAACTTGCATACGCAATTGGCGTAGCACAACCAGTATCAATTTCAGTT
+GATACATTAGGCACTGGTAAAGTATCTGAAGACGTATTAGTAGAACTAGTTCGTAACAAC
+TTCGATCTTCGCCCAGCTGGTATTATTAAAATGCTAGACTTACGTCGCCCAATTTACAAA
+CAAACAGCAGCTTACGGCCACTTCGGACGTACTGATGTAGATCTTACATGGGAACGTACA
+GACAAAGCAGCTACTTTAAAAGAGCAAGCTGGTCTATAATATATGAAAAAAAGCTTTGCG
+CTGTGTGCGCAAAGCTTTTTTTATTTGGTTTTATCCCGCATTAACTGCCCGTAAAAGCCC
+GATTGGTTCAACTAATAATCAGTGGGGAAGAACAAAATCCCCACTGATTAAAGTTTCACT
+TTATTTACTACTTGAATGCAAGAACTACAATAAACTTCCCCGTCTAGCTCAATATACTTC
+TTCATATTTGTCATACCACTTGCCGGAAATGGCATATGAATCCACGCTTTTTCATACGTT
+TGTATTTCCTTTTCACATGATTTACAAAGGATTGGTTTCTTACGGAACATAGACGGTCAC
+CCTTTCAGTTGGCGTGCTTTTCCTGCGCAAAAAGCACTGCTCAGTAAAAATAGCGTTGCG
+AATATAATACTCACTAATGTAGCGTATGGAATCGCGCCTTTTAAGGAAAAGCCGACAGTG
+ATGGAAGCAACAAATAAGAGAATGAATGTTGTTGTTAATTTTTTGTAAAGTTCCATAGTG
+AGTGAACCTCCAAATTATTTTGTAATTTAAAATGAAATCTACTATGTAGAAAATATAAGG
+GGATTTAAAGAGTAGCTAATGGTGTGTAGTCCAGGCGTATAAGAAAGTATATTTTCCTTT
+TTGTGGTCGTATATACTTATATTGTATCACGGTGCATCATTGGCTTCATACATAATTGTG
+TAAAGATATGTATGATAAAATGAAGAAAAGTCTTTAGGAAAGGAAAGATGAAAAATGAGC
+GTAACTGAACATAAAAAACAAGCTCCAAAAGAAGTGCGCTGCAAAATCGTGACGATTTCC
+GATACACGTACGGAAGAGACGGATAAGAGCGGACAACTATTACATGAATTATTAAAAGAA
+GCAGGACATAAAGTGACCTCTTATGAAATTGTGAAAGATGATAAAGAGAGTATTCAGCAG
+GCTGTGTTAGCTGGTTATCATAGGGAAGATGTTGATGTCGTGCTAACGAATGGTGGAACT
+GGTATTACGAAACGTGATGTAACGATTGAGGCAGTATCAGTGTTATTAGATAAAGAAATT
+GTTGGATTTGGTGAGTTGTTCCGTATGATCAGTTATTTAGAAGATATCGGAAGTAGCGCA
+ATGTTAAGTAGAGCGATCGGTGGTACAATCGGGCGTAAAGTTGTCTTTTCGATGCCAGGG
+TCTAGCGGAGCGGTTCGTCTTGCGATGAACAAGTTAATTTTACCGGAATTAGGTCATATT
+ACATTTGAGTTGCATCGTCAATGAGTAAGTGTGCTGGAATTGTATTAGCAGGAGGTATGT
+CGAGCCGATTCGGTGAGCCGAAAGCGTTAGTAGGCTGGAAAGAAAGTACTTTTATTGAGC
+ATATTGTGAAAGTAATGGAAAGCGCTGTGCAAGAAATTGTAGTCATTAGTCATACTGATA
+TAAAAGAGAGAGTAGAGCAATTAGTACAAGTTCCAGTTATAGAAGATATGTCGCACTATA
+AAGGAAATGGGCCACTTGCTGGAATAGTGTCAGGAATGGAATACATAGATTCAGATTGGT
+ATATTATCATGCCTTGTGATGCACCGAACGTTTCAAATGAATGGATTACCATTTTATTAG
+AGCAAACGAGCGATGAATATGATGCTGTTGTCCCTATTATTAATGGAAGAAAACAACCGT
+TACTTGCAGCGTATAATAACCGCGTGAAAGAAAAGATTTATGCTTTGCTTCAAGAAGAAA
+AAAGAAGTATGGGCCAGCTTTTATCACAATGTAATGTGAAATATATTGCTGGTGAAGATG
+TACAAGCGAATGTAGATTGGTTTATAAATGTGAATACGAAAGAAGAATATGTGCAGGCTC
+AAAAAGACCTTTCAAATGAATGAAAGGTTTTTTGGTATACAGAAATTGGAGAACAATTGC
+TGTATAAAGGTATGTGAGTAAGTTGATTTTAAGGGGATTTCGTGAACTACCCGCCACTTA
+ACGTCCTAAAGGAGTGTTTGAAGTGAGGGCTTCTCGGTTAATCATTACTTCTGATAGCTA
+ACGAATTCGTCCTAAGACAGCCGAGCTAACTCCCTTGTTCCAAAGGTTATTTTATTACAA
+TTTATGCTGACGCTAAAAGACGTATTGCTTCATTTTTGATATTGATGGCTGAGTTATAAT
+CTCTATCGAGATTTACACCGCATATACAAGAATAGATTCGTTCAGACAATGTCAGACTTT
+TCACATTTCCACAGCTACTACATGTTTTTGTTGATGGAAACCATTTGTCTATTTTCACAA
+GTTGTTTTCCTTGTTCGTTTAGTTTATAAGTTAAGAAAGAAGTGAACATACCCCACCCAT
+TATCAGCGACACTTTTTCCAAAATGAAGTGCTTGCGATATTCCTTTCATGTTTAGATCTT
+CAATAGCTACAACATCAAAATTGGCAGCTAACTTTTTAGACTCATGATGAAGAAAATTCT
+TACGTTGGTTAGCTACTTTCTCATGTAACGTAGCTACACGAATACGTTGTTTATTCCAAC
+GTTCAGAACCTTTATTGCGTCTTGATAATACTCGTTGCGCCTTTGTTAATCGGTCTAACA
+TGTTACGATAGAACTTAGGATAATTGGCTTTCTCATCCTCAGAACTGACGTATAATCCAT
+CCATTGCAAAGTCTAATCCAACAACTGTTTCTACTTCTTTTTGTACAATCTCTTTTTCGT
+ATTCAGTCAAGATTGACACATAGTATTTACCAGTAGGTGTCATAGAAATCGTACAAGACT
+TGATCATATAATCTTGTGGTATCTCTCTATGTTTTTTGATACGTACCATTTTCAGTTTTG
+GCAATTTGATATGACCATTAAGCAACAGAATATTACCGTTTACTACATTCGTTGTATAAG
+ACTTTCTGTCCTTTTTACTTTTGAATGTTGGGAAGTTATTTTGACCACTAAAGAAATTCT
+TATATGCAGTTTGCAAGTGTAGTTGAGCATTTGCAAAAGCTAATGAATCAACTTCTTTTA
+ACCACTCAAATTCTGCTTTATATTTCGCAGGGGTTGGAGGCTTTTGTTTCTTTAGTTGTT
+CCTTATCATCTTTGTATTTTTCGTACGCTTCTTTTCGCTCAGCTAACATTCTATTGTACA
+CGAAACGTACACAACCGAAGGTTTTACGTATAAGATTTGCTTGTTCTTCTGTTGGATACA
+ACCGGAATTTATATGCTTTATTCTGCTTTGTCATATCATTTCACCTCACTTTTTACCTTG
+ATTTTCAATATGTTTCTTTACTACGTCTATTGGCGAACTACCAGTAGTTAGTAAGCAAAA
+ACTTCTTGACCAAAACATTTCTTTCTAAAGTTTTTTTCACTTGTGGAAAGTCTTTCTTGA
+TTAGTTGAGAACTTGCACTTTTATAAGCATTAATAAATTTTGTCATTTCTTTTTAAGCGA
+GTAATTCTGATGCGGTGTGCTGAAGGACTGTTTCATATTGGTCAAGTAAGCCACGAAAGA
+TTCCATCCCAGCTTTTTGATTGGGCATAAGACGAAGCAGCTATACCCATTTGCATAAGCT
+GCTCTTCATTTTGTAATAAAGAATGGATGGATGATAGAAATGAATCTGCATGTTTGGGTG
+GGCAAAGAACTCCTGTTTTTCCATCTGTAATAATATTTTTAACTCCGCCACTATTTGCAC
+CAATGACAGGTGTACCGCATGCAAATGATTCAAGTACGACATTTCCGAACGTTTCAGTAG
+CTGATGGAAATACCATCATATGAGAACAAGCATATGCTTCAGCTAAATCCGTACCTTGTA
+AATATCCAGTAAAAGTGACATTTGTTTTCGGAACAGCTTCACGCAAATTTGTTGCTAGAG
+GCCCGTCTCCAGCGATGAGCCAATGAATATCGTCACGTTCTTTGTTTGTCGTTTGAATAA
+GTGTTTGAAGAGTATCGATATCTTTTTCAGGAGCAAGGCGTCCGACGTAGGAAAGAATAT
+GTTTCGCTGTAATATTATATTTTTTTCGGAATAGGTCTTTATTGTAAGTTGGATGAAAGA
+GAGTACAATCTACACCACGTCCCCAAATATAGAGCTGTTGAAATCCTTTTTTCTTTAATT
+GATGTAATGTTTCAGGAGAAGGAACAAAGTTTTTTTGCATATGACTATGAAACCAGCTTA
+AATAGTTCCATAGCATATTGGAGAGAAATTCGATTTTGTAATAGCGTAAATAGGCGTCAA
+AATCAGTATGATAAGAACCGACAACTGGGATATTTAACTTTTTGGCATAATATAACCCAC
+AAAGTCCCATATTGAAAGGCGTAGCGATGTGAATGATATCAGGTTTAAAGGCAAGAAGTT
+CCCGCTTAATGCGCGGAGTAGGAAAGGCAAAGCGACATTCTGGATATAATATTGTTAACG
+GGATACTTCTCATTTTGTTCACATTCGCTACGAAATTATCTTCTGCCGTATGCTGAGGGG
+CGAAAACAGAATAGGCGATATTTTCTTTTTGAAAATATTTAGTTAAACGTTCCAAAGTTT
+TCGCCACACCGTTGACTTGTGGTGTAAATGTATCGGTAAATATGGCGACTCTCATCATAT
+CGCTCCTTTACATGAGTGGAATGAGTTGATAAAAAGAGATGATGCCAGAGCAAGTGCCAA
+GGCACATGCCTACAAATACATCTGACGGATAATGAAGCCCTAAATAAATACGGGAAATAC
+CGACGCATAATGCTAACGGTAATAGAAAAGCAAGCAAGTTTGGATTATAGCAAATAAATG
+GAATGAGGACAGAGAAAACAGCCGTTGTATGTCCGGATGGAAAAGAATGATCTTTTAATG
+GATGAACTGGATATTTCGCATCCTGAATTGTTAAATAAGGGCGTTTTCGTGGATACCATC
+TTTTTAATATTTGCACAGGAATATGGCTAATTGTTAAAGAAATAGCAGTTGCAATTGCAG
+CTTGATGCAAATTCCCTGTTGCGAAAATTAAAAAGAATAGGGTAAGTGCAATGGAAAAAC
+TTGCACCACCGATATGGGTAATATTGCTGAAAAAGATGTTTAATGTTTTTTGATCAAAGT
+AGCGATTAATTCCTTTGAAGATGTAACATTCTATTTTATATAGTCCACTGACCTTCATGA
+GATTTTTCCTCCCTCATTTACATATATATGGAGTTATTAACTTCTATTTTAATAAGATTT
+TATTGAGGGAATAATAATGTTTTGTAAAGAAAAAGTTAGATTTTTTCATAAAAAAAGCTG
+CCAGTCTTATGGCAGCGATAAAATCACTTTTGTAACGATTTATAATATTGTCCTTTTTCA
+ACGTATTGTGTGCGGATACGTTCCATATCTTTACGGTCTTCTTCTGTTAATTCGCGAATG
+ACCTTCGCAGGGCGACCGAAAGCTAACGTATTAGGAGGGATTTTCTTTCCTTGTGAAACG
+AGACTACCAGCACCGATGAAAGCTCCTTCACCAATTTCAGCGCCATCTAATATGATAGAT
+CCCATTCCGATTAAAGCATCTTTTTCAATTTTGCAGCTATGTAAAATAACTTGATGCCCA
+ACGGTAACGTCATCTTCTAAAATAAGAGGATACTGGGGGCTTTGGTGAAGTGTACATTGA
+TCTTGTACATTTACTCTATTTCCAATTATCGTTGGTGATACATCACCGCGGATGACTGTA
+TTAAACCAAATGCTAGATTCTTCGCCAATTGTCACATCGCCTGTAATGGTAACATAGTCA
+GCGATAAAAGCACTACTCGCAATTTTCGGATTTTTTTCTTTGTAAGGATATATCATGTAA
+AGCCTTCCTTTCCTAGAGACTAGTTTTAGTGTATCAAATTATGAGAAAGAGTGAAATGGA
+GGAGGTCCGTATGTGGAATTATGAAGCAGAGGAAGCGAAAGCTGTAGTCGTTATCGTGCA
+CGGCGCAATGGAATATCACGGACGTTACGAAGCTATAGCAGAAATGTGGAATCATATCGG
+CTACCACGTTGTGATGGGAGACCTTCCATCACATGGAACGACTTCGAGAAATAGAGGACA
+TATTGATTCATTTGATGAATACATAGAGGAAGTTAAATTATGGGTGAAAGAGGCAAGGAA
+GTATCGATTACCTATTTTTATATTTGGTCATAGTATGGGTGGTCTTATTGTCATTCGTAT
+GATGCAAGAAACGAAGAGAGAAGATGTAGATGGTATTATTTTAAGTTCACCATGTTTAGG
+TGTATTAACTGGACCTTCTGCTCCGCTTCGAGCTGCCTCAAAAATATTAAATGTTGTTGC
+TCCAAAATTGCAATTTGCAACGAATCTTACAGTGGAAATGTCAACTCGTAATCATGAAGT
+GAGAGATGCGATGGAGAATGATTCATTGTTCTTGCGCAAAGTATCAGTACGTTGGTATAG
+TGAATTGATTAAGTCTATCGAAATTGCGCATAAAAAAATAGGCGATTTTCCAGACGTTCC
+ACTCTTGCTAATGCAGGCTTGTGAGGATAAACTTGTAGATAAAACACGTGTCCGTACTTG
+GTTTGATAATGTTAAAATAAGTGATAAGGCTTTTAAAGAATGGCCGAATTGTTATCATGA
+GTTATTAAATGAGTATGAGCGTGATGAAATTTTGAATTATATTCAGTCATTTACTGAAAT
+ACGCATCAATAACATAATAGAAACAAATAAGTAAATTATTTGTACATTGAATAGAGGAGA
+TGAAGGAAGAAGTGAACGTACCGAGTAATCCCATAACGCTCATGGCGAAAGTATACCGTG
+ATGTGTTTCCGGTAGTACACCATGAGCTAGCGATGTGGAAAGAGCGTGCCTACCATATTC
+CGAATGACGAGCTTCATAGTCAGGCAATCGCAAGTATTGAGAATAAAACGTTTCATTGCG
+AGGGCGGTGGCATTTTAGCGCTACTAGCAAATGAACATCGTGAGGAATGTATTCGTTTTA
+TCGTAGCTTATCAAACGATTAGCGACTATTTAGATAATTTATGTGATCGTAGTACATCAC
+TTGACCCGAAAGACTTTGCGGCTCTTCATGAGTCGATGGTAATGGCATTAAGCCCTGAAG
+TTGAAGGGGGCGGTAACTATTATCGTTATCGTGATGATCAAGATGATGGTGGTTATTTAG
+ATGAGCTTGTTGAAACATGTCAGGATGTTTTAAAGAAAACGAAGCATTATGATAAAATTG
+CTCCAATTCTTCATGAACTTGCTTGTTATTATTGTGATTTGCAAATTCATAAACACGTGA
+AGTTAGAAGAAAGAGAACCACGCTTAAAAACATGGTTTGAAGCGCATAAAGAAAATTTAC
+CACCGATGAGTTGGTTTGAGTTTTCAGCATGTGCAGGTTCTACGCTTGGAATTTTCTGTC
+TTGTCGCATATGCATTTCATGATGAATTACATGATGAAGATATTGCGAAAATTAGACAAG
+GATACTTCCCTTACGTACAAGGACTTCACATTTTACTTGATTATTTCATCGATCAAGAAG
+AAGACCGTATAGGCGGGGATTTGAATTTCTGTAGTTATTATGAAAACGAGCAAGCTATAT
+TAGATCGTATGAAACATTTTGTAGAAGAAGCAGAGAAGAGCATTGGTGATTTGCCTCATG
+CGAAGTTTCATCGTCTCATAAGCCGAGGATTACTTGGTATTTATTTATCAGATCAAAAAG
+TATCAGCGCAAAAGAATATGCATAAAATGGCACGGCGCATTGTAAAATACGGAGGGCTCA
+CTTCACGATTCTTCTACTGGAACGGGAAGATGTACCGAAAGAAAATGGCGCAGTGATGAA
+GAGACCATCTCAAAAGGTATTTTGGGATGGTCTTTTCCTATTGTCGTATTTTGTAGTTAA
+GTCGATATAATTTCATGTGCTGTTGCAATCTTGCTCCATAATGAAAAAGGGACAGTCCAA
+AATTAGATTTTTTGGACTGTCCCTTTTTACTATGATCGTATTTTTAAAAATACATATATG
+AGAAGTTCAATCGCGAAAATTACTAAAACAGATAGTCCGAATAAAGGCATGACAGCGCCT
+AGTATAACCATCATGATAAAGAAAACGATTATGCTTTTCTTATCTCTTTGCTTTGGCGGT
+GCTGCTAATTTTCCTTTTGGCTTTCTTGCTAACCACATTTTTATTCCGTAATAAATGAGA
+AGTAATAAAGATAATGTCGTTAGTAAGCATAATATTTTATTTGGCCATCCGAATAAATGT
+CCTTCGTGAAGCGGGATACCGTAAGTGAACCATTGTGCAAATAATCCATAATCACGATAG
+TCCGTTTTCGAAATGAGTTCTCCGCTATATTGATCAAAGTAAGCTGTTATTTCTTCATTT
+GGTGCGACATGCATACCCGTAATACCGGAACCGCTTGATTTCGAAACGGTGAATACACCT
+TTCGGATCAGCCGGTAGGGAGATAACATATGGCTTCTTTATTTCAATTCCTTTTTGTAAT
+TCATCGACAGAAATTGCTTTTGGCTCATTTGAATTCGATTCAGGAGGAGCTTCTTTTCTT
+GTTGCCCACGGCAATTCTTTTACCTTTGATTCAGGCGGTGCCATATACAACTTTGGATAT
+CCAATCGATTCATTCGACGATGCGATTTTATAAATTTGGTTACCCATAAATCCTGACCAA
+GGCAATCCAGATGCGACTAGCAGAACGAGTGGAATTGTAAATATAATACCGATAATAGAA
+TGACGTCGTTTTGCTTTTTCTCGCTTATTGGATGCTGGTGTGTTTTTGAATTGGCGTATA
+CTCATATACAACCCAGTCACAATTAAAAAGATTGTCCAGCACGCTGCAAGTTCTACAATA
+TAATTGACGACAGTGCCACCGACTAAAAGGGAACTATGTAATTCCCGCATTATATTGGAA
+AACGTTTCAGCTGTATTTTGATCCCCAACAATTTGATTATTGCTATCTAAATACACAAAT
+TTTTGCTTTCCTGTATATTCATTAGCAATCGTAAGCCTAGTATTATAATCCCCATTAAAC
+TCACTAATTTTCGTCACGCTATAATGCGGATATTTTTTCTCTGTTAAGAAAAGCGAATCA
+GCCATCGAAATAGATTCTGTTTGGGCGCTCTTCCCAAAATATAAATCTTTATAGATGAAA
+TCTTCAACTTCCTCACGAAATAAATACCCAATTCCGCTCAGTGACAAAGTAATAAGAAGC
+GGCGTAATAAAAAGCCCGGCATAAAAATGCCAACGCCAAAAAATATAATGAAGCGAACGA
+TTTTGTTTCATACGACAGTTCCCCTAACCTTCCCTATATGAATAAACTACTTATTTAATA
+TAGCGAGATTAAGTGTGATTACTTTGAAAGAATTGTGAAAAAAGTTAAAAGTTTTGGGGA
+TTTTTATCAAACACAAAGCACATTTCAAAAGGGATGTGTTTTATGTTTATGAAGACCTTT
+TTATATTTGATGCATAGATCCTAACAACTGCTTCCGCAAGACATTGAGCGGAATCAACAA
+AGTCCTCACTCACCACCACATTCAAATCGGTACATGCGATAATAGCGGTATCTACTTCGT
+CTTTTAACTGTAAAACGAGCAGACTCCATAATTTGCGAGCTTCCTCAATTTCTCCGCCTT
+TAATACAAGTAATAATTTGATTAATCATTTCTTGCCATTGTTCATTATGAATGTACTCTA
+TATTACGTTTTGTAATCCCGTCTTGGTAAATACCTGCTTGAACAGTCGCTTCTGTTGCAA
+GAAGAGCGACTCTTTTTGTATTTTCAGGAATTGCTTTTAACGTCTCATCGACTATATTCA
+AAATAGGAATGGTAATAGAACGCTGTAATTCTTCGAAATAAAGATGCGCTGTATTACATG
+GCATTGCGATGAAATCTACACCAGTACTTTCAAGTCTTTGCGCTCCTTCAATAATCGCTT
+TTTTCATCGCCGCATGATCAATAGGGCGATCCATATAAAACGGTGTTGGGCACGAATAAA
+TCATCATATGAGGAAAGTCCATATCATGCTTTGCTCCATATATTGTTTGGCACCCTGCTA
+CAACTGTATCGACGAATGGTCCGGTTGATTTTGGACCCATTCCTGCTAGTATTCCAATCA
+TTGTTTAGTCCCCTTTAATATGTAATCAAAAACGTTTTCTGCGAACGAGAAAAAGAAATA
+AAGTAAGTAATAAAAATGAATATACGATAGCCCAAGCTGTAAGCCATAGAGTATGAGTAA
+GTATATTATATTTGTATTGTCCAAGCATTATAAAGCTTTCGACAGGTGGTAAAAACCATA
+GTAACTCTTTTTTTAACCGGATTGAGGCAATCGTCATAAGTAATATAAATGTAAGACTAA
+GCCAAGCGGTGCTTGCTTTTTGAATAATATTTCTAGTAAATAATGTTGCGATTGAAATTC
+CTAGTATAGATAAAGACATGTGAGCGAGAAATCCGACTAGAAATAAAGAAGCTGTCATTT
+TTTCATTAAACATTTGCAAAATAATTGGATAGATTACGGATATAAAAGATAAAACAGTAC
+AAATAAGAAGAGCCGTAACATATTTACCAACGTATAATGCCGAAATATTATTTGTATGTG
+AAATAGTGATTTGTTCTTGTACAAGATCTTCAGTATGAAAAATTGTGACTGTAATCCAGG
+CAGATAATAAATAAAGTGCGAGTGCTGTTTCTAAGTATGTCGGTACAATGGGAGTTGGTT
+TATATGTATATACAAAAAGTAAGCTTATGCAGTACATCGCAATAGGAGGAATGTACTTAT
+ACGATTTTGTGTAGTCGAGAAAATGGTAACGAATAAGCGCAAACATAATAAACCTTCTTT
+CGATTTAAAAATTAGGCTGTAGCAGTGTGATAGATGCTTTTTTATGTAATAAAAACTGAA
+GCATTTCGTTTGTATATTCCTTTTCGATTTGTAATTGAATGAGGTTTTGATTTGAATTGT
+GTGTAACTTGTATAAATCCTGATTGCTTTTGTAGTTCTATAGATGAAAATGTTTCGTGAA
+CAATTGCCTCAATATAGACCTGTTCTGTTGATTTTTGCACAGAGGTATCTTCCGCAATTG
+TATGATTTGCTAATGTCACAATTCTATCGGCGAAGTTTTCTAGTAGTTGTTTTTCGTGAC
+ATGTGAAGAGTATAGATATGCCTTGTTGTTTTAATGAGAGTAAAATATGCTCTAGTTCTT
+GCTGAGAGTTAGGGTCGAGTCCGGAAAGAGGTTCATCTAAAATTAATAAATGGACGTCTG
+TAAGTAACGCTTGCATAATGCCTGTTTTTTGTTTCATACCTTTTGAAAAGTTACGTACAA
+TGGAATGCTTTGCATGATGTAAATGAAAAGATTCAAGGAGGATCGGAATTTTATTTCTTA
+AATATTTTGTTGATAAACCGTGAATGTGGCCGAGATGATATAAATAATCCTCTAATGTAA
+AACGAATTTCTTCTGGAAAATGTTCAGGAACATATCCGATTTGTATATGTTCTTTTCTTT
+GAAGTGTCCCTGCCGTAGGTGAAATAAATCCTGCAATTATTTTGAGTAGAGTACTTTTTC
+CAGTCCCGTTCCCGCCAATAATAGCGAGTGCTTCTCCTTCTGGAATGGATAAATCGATGT
+TGTCTAGTATGAGTGATTTGCTGTACTTCTTTTGAATTCCCCTTAGTTCTACTAGCAAAG
+TTCTATCCTTCTTTCTTCAAATATTGTATACATCCATTATATAGGAGAATAAGAAAAAGA
+CGTGCAATGAGTGCACGTCTTTTTTTGTTATGTTTTGTCGAACAATCGATATATCTGAAA
+AATCGTTGATATAATTATCCCGCTATTTGCCGGACAGTAAACCTCACTGATTAAAGTTTC
+ACTTTATCGCTTCTCAATCGCCACAATAAATGGTGGGTTATTTTGCTGGTTAATGAAGCC
+GTATCGCAAAACGTGAGCTTGTTTTTGGTCGAGTTCTTCTGCAAATTTGAGAACAGCGTC
+GCGTTCTACTTGTCCTTCTGGATGTCCGTGGTAAATGACAAGGACGATGATACCTTCAGG
+TGCCATTACTTCTAATAATTGCTCGATCGCCGAGATTGTTGAGTTCGGTTTTGTAACGAT
+ATGTTTGTCACCGCCAGGAAGGTAACCTAAGTTGAAGATAGCGCCTGTTACTTTTCCTTT
+TGCTTCTTCTGGTAGTACGGATAAAAGTGTATCGTGACTATCGTGAACTAAAACAGTGCG
+TTCGAAAAGTTCTTTTTCTTTTAGGTGGATAGTAGAACTTTCGATTGCTTCTTGTTGTAT
+ATCAAATCCAAATACTTTTCCGTTATCTCCAACGATTTCAGCTAGGAAGCAAGTGTCATG
+CCCATTGCCGAGTGTTGCATCTACAGCGTAATCGCCTTCTTTTACTGCCGTTTGCAGCAG
+CGAGCGAGCAAACGGTAATACACGTTCTAATTTCATTTTTGTTTCTCCTCATTTGCATAT
+TTTCCTTGCCAGCTTCCGCGGCGTACAAATTCTGCATCGATGGAATTTAATACTTCCCAT
+TTATTTAAGCTCCACATTGGACCAATCATTAAGTCAGGCGGACCGTCACCTGTGATGCGG
+TGCACAATTACGTCTTCTGGAATCATTTCAAGTTGGTCAACAACGAGACTTACGTAATCT
+TCAAGAGAAAGGAATTCTAGTTGTCCTTTTTCATATTGCTTCACCATTGGTGTTCCTTTT
+AATAAATGAAGTAAATGAATTTTAATTCCTTGTACATCAAGCTTCGCTACTTCACGAGCT
+GTTTCCATCATCATGTCGTAATCTTCAAGTGGAAGACCGTTAATAATATGAGAGCAAACT
+CTAATGCCATGTTTGCGTAATTTATTTACGCCTTCCACATAAGATGGATAATCGTGAGCA
+CGGTTAATAAGATTTGCAGTGCGTTCATGAACAGTTTGTAGTCCGAGTTCAACCCAAAGG
+TATGTACGTTTATTTAAGTCCGCTAAATATTCAACGACATCGTCTGGTAAACAATCTGGA
+CGAGTTGCGATAGAAAGACCGACAACGTCTTTTTCTGCTAGAAGCGGTTCGAATTTTTCT
+TTTAACACTTCAAGTGGTGCATGTGTATTTGTGTAAGCCTGAAAATAAGCGATACATTTT
+CCGTCTTTCCACTTTGAGTGCATTTTTTCTTTCATTTCATGATATTGCGTTATAACATCA
+TCGCGGCGATCGCCAGCGAAGTCACCAGATCCAGCAGCACTACAAAACGTGCAGCCGCCG
+TAAGCGACTGTACCGTCACGGTTCGGGCAATCGAAGCCAGCATCTAATGAAACCTTAAAG
+ATTTTTTCACCAAATTCATTTCGTAAGTGGTAATTCCATGTATGATAACGTTTATTGTCA
+TTTGTATATGGAAAAGGGTTTTGAACCTTCATTATTTTCCCTCCTAAGACGAGTCAAAAT
+GAAACAAAATCCATTATAACATACTCATAAGGTTCATATGGAAGGGACACACTAAAGGGG
+AATTGAAGCAAGGAGGGACAATTATGGCAGAGCGTCAATCACTTGAAGAGTATATTACAC
+AGGCAGAACAAGCGGTGGAATATGCGAAAGAACAATTAGACCAAGGCATGAGACAGGAGC
+ATTACAATACGATGGAGTATTCGGATGCTCAGTTGCAATTAGAACAAGCATATAATGATT
+TACAAACGATGCAACAACATGCGAATGATGAGCAACGTGAGCAATTAAATAGAGCACGTA
+TGGCAATTCGCCAATTGCAACATCAAATGATTATTACACCGCACTAATAAGGAGTGAATG
+TAATGGCGAAACGTTCAGATCAAAACAATCCAGAGCAAAAAACGCAAAACGGACATAACG
+CTGAGTTTTCGAATGAACTTGATCCAGTTGTTCAAGTGAAACAGCGTAATAGTAAAAAAG
+GACAACCTCAAAGATCAAAGCAATCAGAGTAAACCAGGTCGCATTATGACCTGGTTTTAT
+TTTGCCTCGTGATTGGTGCGGGCTAATCAAGGGGCAAAATAATACTGATTAAAGATTTAA
+TTCATTATATTACAATAATGTAAGATTACTGTAAGGTTTGCCGATAGTTACGATTGTCTT
+TTTCCAGTAGAGTAAGGGAGGATTTAATTTTGGACAAGGAGTTGTATTATGGGGAACAAT
+ATTACAAACAAACGAATTGATGAGTTAGATTACATTCGTGGCTTCGCATTACTGGGGATT
+ATTTTAGTAAATATTCTTGCACTACTGAATATTAAAGTTCCAGATCCTAGTACAGTGGAT
+GCAAGTTATCAAAGGTTTCTATACTTATTTGTAGAAGGTCGTTTCTTCTCAATCTTTTCA
+TTCTTATTTGGAGTAGGATTCTATATCTTCATTACAAGAGCAATTGCGAAAGGGAAGAAT
+GGATATGTTCTATTTCTACGCCGCTTAGTTGCACTATTTATTTTTGGTTTGATTCATCAA
+ATGTTTCAGCCTGGGGAAGCACTAGCGTTATACGCAATTTGTGGATTAGTCACTTTACCA
+TTTTATAAAGTGAAGAAGCAAATAAATTTAGTAATCGGTCTTATTCTTACGATAGTTTTT
+AGTATTATGGCAGCTAAGGAATTATTACCATTAGGTTTAATTTTATTAGGTCTTGCTGCA
+GGACAGTACAAAGTATTTGAAAATCTTTCAGCGAAAATAAAGCAAGTCGCTATTTTTACA
+GGAGTTATGTTTGTTTTAAGTGTGATAGCTTTATGGTATCAATATGGGCACGTTCCTGCT
+AATCCATTTGTAAATATGATACTTATGACTGAAGATGGAACAATGGACGCTGCAGGTCAA
+TTCTTAAAAATTGGTGTTACAGTTGGACCAATTATTTCAGCTTTCTATGTAGGAGCATTA
+ATTTTATTACTTCAGTTAAAACCAGTTCAAGCATTGTTAGCGCCACTGAAATACTATGGT
+CGTATGGCTTTAACAAATTATGTTGGACAAACTGCAATGATTTTAATTGCAGGCAGTGTA
+TTTAATTTTGCAGGAAACTTAACGTACATGCAGACGCTATATGTGTGTATCGCAATTTAT
+GCAATTCAAATTATTTTCAGTGTGATTTGGATGAAAATCTTTAAAATGGGTCCATTAGAA
+TGGATTTGGCGTGTTATTACGTATTGGACGGTAACGCCTTTAAAGAAATAAGAGTAGGAA
+ATAGGCTGTTCCACATGCGAAACAGCCTATTTTTATTGTCATCTTTTGTCGGTAAGTCGA
+TATATTTGAAAAATCGCTGATAAAATTGCATTTACTAATGAAAAAACTAAGCTTACATGC
+TCAGTTTTTTTTCTTACAAAAGTGTAAGGTAATTGTAATGTTAATAAATAGCAGTTCACC
+TCCAAAAGGCGCAAAATAGGTAATGGAAAAACAAGCGTAGGAGGATATATATGACGAAAC
+CAGTTGTAGACGTGAAAAACGTTCAAAAAGTGTACGGTAAAAAAGGTGAGAACCAATCAC
+ACGCGTTAAAAGGTGTTTCATTCTCAATTCAAGAGGGTGAGTTTGTTGGTATTATGGGAC
+CATCTGGTTCTGGTAAAACGACATTATTAAATGTAATTTCAACGCTTGATAAAGCAACGG
+GCGGCGTTGTTGAAATTGCGGGTACGGATATTACGAAAATGAAGCAAGGTGAGCTTTCTG
+ATTTCCGTTCACAAAAATTAGGATTTATCTTCCAAGACTTTAACTTATTAGAGAACTTAT
+CTATTTATGAGAACATTGCACTTCCACTTTCCCTTCAAGGTGTTTCATCACGTAATATTG
+GACCGAAAGTAGAGAAAGTAGCGGATATGTTAGGGATTACAGAAATTCTTCAAAAGTATC
+CAACTGAAGTATCCGGTGGACAGAAACAACGTTCAGCAGCAGCACGTGCACTAGTGCATG
+AACCGGCAATTATTTTAGGAGACGAGCCAACAGGAGCTCTTGATTCGAAAAATGCAGCAA
+GTTTACTTGATGCGATGACAAACTTAAATGAAGAACAAGGCGTATCTATTATGATGGTTA
+CGCATGATCCATATAGTGCAAGTTACTGTCAGCGTATTTTATTCATTCAAGATGGTGAGC
+TATATAAAGAAATTCACCGCGGTGGTACGCGTGAAGAATTTTATAAAGAAATTTTAGATG
+TGCTTGCGGACTTAGGCACACAAAAAGCGTAAGAAGGGAGGTCTAGGGCATGTTATTTAA
+ACTTTCCATGTCAGGGCTAAAGAGTAAGCTGAAAGATTATATTGTCTTACTTGTTGGTCT
+TGTCATGTCGATTTCAATTTTTTATATGTTCCAAACGTTAGCGCTGAATAAAGCGTTTAT
+CGAATCCAATTCTGTTATTAAGTCTATTGGTTTCGTATTCCAAGCAGGTTCATTTTTATT
+AGCAATTATAACGTTCTTCTACATTTTATATGCAAACTCTTTCTTATTATCTCTTCGTCA
+AAAAGAGTTTGGTATGTACATGATGTTAGGTGCAAAAAAGCATAAAGTTACATTACTTAT
+GTTTATTGAAACGATTGTATTAGGTGCTGCGTCTCTTGCGATTGGACTTACAGTTGGTGT
+AGGACTTGCAGAAGGTATCGGACAGTTATTAATGAAACAATTAGAATTTGCTGGTGAAGG
+CTATAAGGCATTTTATCTACCATCTATGACTGTTACTTGCATTTTCTTCTTTGCATTATT
+TGTATTATCAGCAATTATGAACAGTATTAAGTTATCACGTATTTCAGTACTGCAACTTGT
+ACATGCAGATGCACAAACAGAACGTGTTGCGGTAAAAGGAAAAATGACAGGTGTCGTTGC
+AATCCTTGCTGTTATTTTATTAGGAATTGGCTATGCATCAATGATTTACATGGAAAAACT
+AAGAGAAATGGGAATCCTTATTGCATTAATTACAACAACAACTGGTACTTACATGCTATT
+TGGATCACTTCTCCCAGTTATCATTAGAAAGTTAAAGAGTAATAAAAAGCGTAGTGAAAA
+AGGACTTAATGCTTTTACGTTTGCACAATTAAATTTCCGTATTAATAGCTTAACGAAAGT
+ACTTGCAACAGTAGCGATGTTAGTTGCTCTTGGAGCGGGTGCAATTTCAGGTGGTATGGC
+GTTTAAAAATAACGTTATAAAAATGGTTGATGGTTTAGTAATATATGATTCAGTTATTCA
+TAACCCAACAGCTGAAGAAAAGAAAATTTTAGATGGTATTACATTTAAAGAGAAAAATGA
+ATATCGTTACAAAGTTGATAATAAATACGTTTATTATGTAAAAGAAGATTTAGAGAAAAA
+ACCTCCTTTCGTACAAGATACAAAACAGATGGAAAGTATGAAGGATTTAGGAAAAACAAA
+GAAAGTTTCAGAGGAACTACCAGTAGGTGCAGTTTCTAGAGAAATGAATGAAAAAGATGC
+GAGTGCTAAAGAACTTCCAGAAGAATGGAACGAGGCTTTCAGAACAATTCAGCCATTTTA
+TCTATATGAAGATCATGCAATTAAAATTGTAGATCAGAAAATGTACGATACTGTAAATGG
+TAAAGAAGGAATCGTAGTTACTGGAAAAACAGACGATTTTGTAGCATACACAAAAGAATG
+GAAAAAACTTGACGAGTTGCAGCTAGTTAAATATAAAAATGTAAAAGCTGAAAGATTAGA
+TAGTAAATATCAATCTTACAATGGATTCTACGGCATTGCGAGTGGAACAGTATTTATGGG
+ATTCTTCCTTGGAATTGCATTCTTAGCAATGATGGCAAGTTGTTTAATGTTTAAAATTCT
+TTCTGGGGCATCAAAAGATATTACGCGTTATCAAATGCTGCGTAAAATCGGTGTGCGCCG
+TGAATTATTAACGAAATCAATTTATAAAGAGTTATTCTTAGTATTCTTATTCCCGGCAAT
+TGTGGGTATTGCTCACGTATTAGTTGGTATGAATATTTTCGGATTTATTTTAGTCGATCC
+GTACTTCCGCATTTGGGTTCCAATCGTAATTTTCGTAGTAATTTATGCGATTTATTACTT
+CATTACAGTTCAATTGTATAAAGGGATTGTTCTTCCGAAAGAAGATTAATGAAAAACCGA
+GCGAAACTGCTCGGTTTTTTATATTTTCAGAAAAAACACTTTAATGTTACTGAAATATAT
+AATATAATGTAAATAAGTAACATAATATGTGAGTATCAGCAACTGGAAAACGAAAGGAGG
+AATTCGATCTATAGAAAGAAGCTGAACTTGTATCCCCTATTTTTCTACCCACACTGTATT
+TGTACAATCATAAATTTCCAAATGCAAATTGCCTGGACCTAAGCAGTATATTGTGAAAAT
+AATGGATAATACATGGAAATCTCATAGCATGATAAGGTAAAATGGACAGGATAATGAGAA
+AATTACCGTTCATAAGATGAGGAGATACATGTATGGAAGTTGTAGAGGCATTAAAAGATA
+TAAACCAAATTGAGGCTATGAAAAAGTATTTAAAAGAGCACTCGCAGCGAGATTATCTTT
+TATTTGTTATTGGGATTAACACTGGATTAAAGATTACTGAACTATTGAGTATTAAGTTTG
+AAGATGTATTAAATGAAGATGGAACTGTTAAAGAGTTTTATTCTCTTCCTGTGAAAGATG
+AAAAGTTTAAACAAGATATTTATTTAAATACAAAAGTAAAAGAGGCGCTTTTAGCGTACG
+TACAATCTTTTGATATTCAAAGAGAAAACTACGTATTTCAATCTAACAAAACAACAAATT
+CAATCTCACGCCAACAAGCGTATCGTGTTATCCATAGCGCAGCTGAAGCGGTCGGAATAC
+TTGGTAAGATTGGAACGAACTCAATGCGAAAAACATTTGGATTTCATGCGTACAAAAGAG
+GAATAGCGATTGCGCTATTGCAAAAGCATTTTCATCACGCAACTCCATCAGAAACGTTAA
+AGTATTTAGGAATCTTAAAAGATGAGAAGTTTAAAACAGAGATTGATGTAGATTTGTAAA
+AGGAAAGAGCCGTAACTAAAAAATTAGGAGGCGGGAATATGAATATTAGAGAGAGTGAAC
+TACCGGGCATTGGATGTAAATTTGAAGTGATAACAAAGGGTAATGAAAAAATGGTTATTG
+TTATTCATGATGATGGAAGAAGGGAAATGTACCATTTTGATGCGGATCACGATGAGAGTA
+TTTCAAGCATTTCTCTTCGTGATTCTGAAGCGAGACAAATTGCGGCTATATTAGGCGGAA
+TGGTATATAGGCCGCAAGCGCTAGACACAATTGAGATGGCTTTTGAAGGATTATCAATTG
+AATGGTTTAAGGTGGAGAATAATGCACCAGTAGTACAACAAACAATTGGGAGCTTACACG
+TTAGAAAAACATATAACGTAACAATCATTGCTATTTTGAAAAAGAATATGAAGAAATTCT
+TTAATCCAGGTCCAGACTCTATTATTGAAGCTGGCGATATGCTCGTATTATCGGGTGAAA
+GACATGAAGTAAAAAGAATTATTAATGAATTGCTTTCAGCAGGAGGTGATTCCTAATCGA
+TGGATACTTTAATTTTTGAAGTTGGAACTGCGTTAGTATTAGTAGCTTTTGCAGCTATCC
+TCGCTGCGAAGTTAAAGTTCTCGATTATTCCGTTTCTCATTATACTCGGTATGTTAGTGG
+GGCCTCATGCCCCAGATTTAGGACTTATCGATTTAAGGTTTATTGAAAGCGGAGAAGTTA
+TTTCCTTCCTCGGCCGTGTTGGCGTCATATTCCTCTTATTCTACTTAGGTTTAGAATTCT
+CAATAAAAAAATTAATTAAATCAGGAAAGTCGATTGCTTTTGGGGGTAGTGTTCATATAT
+CGCTTAATTTCATATTAGGTTTACTTTATGGATATGTTATGGGTTTCCCCTTATTAGAAA
+CATTAATTATTGCTGGAATCATTACAATCTCATCGAGTGCAATTGTTGCAAAAGTAATTG
+TTGATTTAAGAAGATCTGGTAATAAAGAGACAGAACTCATTTTAGGGATCATTATGTTTG
+ATGATATCTTTTTAGCTGTATATTTATCAGTCGTTTCAGGATTAGTACTCGGAGGTGCAA
+CATCATTTGTAGGTGCTCTTACATCCGTACTAATCGCAGTAGGATATATGTTACTATTCT
+TTGTAATCGCTAGAAAAGCTACGCCGTTTCTAAATAAAGTATTAGATATTTCGTCAAACG
+AAATTTTTATTATCGTAATATTCGCTATTTTATTCTTTGTAGCAGGATTTTCAGAAACAA
+TTCATGTTGCGGAAGCGATTGGGGCTTTATTGTTAGGACTCGTCTTTTCAGAAACAGAGC
+ATAGTGATCGAATCGAGCATCTCGTCGTCCCGTTTCGTGATTTCTTTGGAGCTATATTTT
+TCTTCAGCTTCGGTTTAAGTATAGATCCGTTTTCGCTTGGAGGAGCAGTATGGTTGGCAT
+TAGGAGCAGTTTTCATTACTCTCATCGGTAATTTTACAGCTGGAATGATTGCAGGGCGTA
+AAGCCGGGTTATCGCATAAGGCTTCTGCGAATATCGGTTTAACACTTATATCACGTGGGG
+AATTCTCCATTATTGTCGCGAATCTCGGAATAGCGGGTGGCTTAATGGCAACGATTAAAC
+CATTCTCAGCTTTATATGTTTTAATATTGGCGTCGTTAGGGCCATTATTAACGAAGGAAT
+CTGGGAGAATATACTCTCTACTAGACAAAATATTTAAATGGAGTGCTAAAGAAAGTGCAA
+AACGTAAAAAGGAAGTTGGATAACCTTCCGCTAGGGAACGATTCCATTATTTATAGATTA
+ATATTTTACAAAGACGATTAGAATACATTCTAATCGTCTTTGTGCTATTATCTGAATTTC
+ATCAACTATTAATCAGTTGCCTTCCTATTTAAAAACGACTACAATTTTACTGTTATATAT
+ATGAACGAAAAAAAGAGAATAGGAGGGGAGACTATGCCAAGGAAAGTATGGCTATTAGTA
+GCTGGGATGATTATTAATGTCACGGGTGCTTCTTTTTTATGGCCTTTTAATACAATTTAC
+TTACATGATAGTTTAGGGAAATCTTTATCAGTAGCCGGAATGGTATTAATGATCAACTCG
+CTTACTGGTGTAATCGGAAACTTGCTCGGCGGTGTTTTATTTGATAAATGGGGCGGTTAT
+AAATCAATTTTAGTAGGGATTGTCATTACACTTGTATCGATTTTAGGTCTTGTATTTTTC
+CATGGTTGGCCATTATATGTTGTGTGGCTAGCATTAATCGGATTCGGTTCTGGAATGGTA
+TTTCCATCGATGTATGCGATGGTCGGTACGGTTTGGCCAGAAGGCGGGAGACGAGCGTTC
+AATGCAATGTATGTTGGACAAAACGTTGGGATTGCGATTGGAACAGCGTGCGGTGGATTA
+GTTGCGTCTTATCGTTTTGATTATATTTTCTTAGCGAACTTTATTTTATATTTTATTTTC
+TTCTTAATTGCGTTTATTGGATTTCGTGGTATGGAAGCAAAAAAAGAGCAAGAGGTACAA
+AAAGAAGCCGAAACGAAAAAAGGTTGGTCACTTACACCTGGCTTCAAAGCGCTTCTAATC
+GTATGTGTAGCATATGCTTTATGCTGGGTTACATACGTACAGTGGCAAGGGGCAATTGCG
+ACGTATATGCAAGAGTTAAATATTAGCCTTCGTCACTACAGTTTATTATGGACGATAAAC
+GGGGCGATGATTGTTTGTGCACAGCCGCTTGTTAGTATGCTAATTCGCTGGATGAAGCGT
+TCTTTAAAACAACAAATTATGATTGGAATTATCATTTTTGCGGCGTCGTTTATTGTTTTA
+AGCCAAGCGCAGCAATTTACGATGTTTCTCGTTGCGATGGTGACATTAACAATTGGTGAA
+TTATTCGTATGGCCGGCAGTTCCGACCATCGCAAATATACTTGCACCGAAAGATAAGCTA
+GGATTTTATCAAGGTGTTGTAAATAGCGCAGCGACTGTAGGGAAAATGTTCGGACCGGTC
+GTTGGCGGAGCGATTGTTGACTTATACAATATGGAAGTATTGTTTATTGCGATCATGGTA
+ATGCTTGTAGTAGCGCTTATAGCAACGAGTATTTATGATAGACGAGTAAAAGTAGAAGAA
+ACAGTTGAAGAAAAAATTGCAGTTTAGTTTGACGGAACATGCAACATGTTTTAGAATATA
+TTTAAATAAATAGTAATAAAATATCCTTTGGAACAAGGGAGTTAGCTCGGCTGTCCTAAG
+AAAAATTCGTTAGTTAGCAAGAGTAACGATTAACCGAGAAGCCCTCGCTTCAAGTAAGCT
+CTTAAGAGATACTAAGTGGTGGGTAGTTCACATTAACTCATATTTGTAATAACAGTGAGA
+AGGAGTAGTAGTAATAGAAGCTGGTTTAGAGAGTTGACGGTCGGTGCAAGTCAATCCACG
+TTTCGTTATGAACTCGCCTTTGAGTTGCAGTTGTGAAATCATTAGTAGCAATTGCCGTTA
+ATCCACGTTACGGATCTAAGCGAATGTATTTATTACATTAATTTAGGGTGGTACCGCGGG
+AATCTATAACCTCTCGTCCCTTTCTAGGGATGAGAGGTTTTTTGTATTTTGGGCGGTGAA
+AATAAATAGAATTTCAAGGAGGGTATCTCATGAGCTTTAATCATCAAGAAATTGAGAAGA
+AGTGGCAAGGGCATTGGGAAGAGAATAAAACATTCCGTACGCCAGATGAAACAGAAAAAC
+CAAAATTTTATGCACTAGATATGTTCCCATATCCATCAGGTGCAGGCTTACACGTAGGTC
+ATCCAGAAGGTTATACAGCGACAGATATTTTATCTCGTATGAAGCGTATGCAAGGATATA
+ACGTTCTTCATCCAATGGGATGGGATGCATTCGGTCTTCCAGCAGAGCAATATGCACTTG
+ATACTGGGAACAGCCCGGCTGAATTTACAGAGCTTAATATTAATACGTTCCGTAATCAAA
+TTAAAGCATTAGGCTTCTCTTACGATTGGGATCGTGAAGTAAATACAACAGATCCAACCT
+ACTACAAGTGGACACAATGGATCTTCCTAAAACTATTTGAAAAAGGTTTAGCTTACGTTG
+ATGAAGTACCTGTAAACTGGTGCCCGGCACTTGGTACAGTACTTGCAAACGAAGAAATCA
+TTGACGGTAAGAGTGAGCGCGGTGGACATCCAGTTGAGCGTCGTCCGATGAGACAGTGGA
+TGTTAAAAATTACAGCTTACGGAGATCGTCTATTAGAAGATCTAGATGAGCTTAATTGGC
+CAGAAAGCTTAAAAGACATGCAACGTAACTGGATCGGTCGTTCTGAAGGTGCAGAAGTAC
+ACTTCAACATCGACGGTACAGATGAGAAGTTCACAGTTTTCACAACGCGTCCTGATACAC
+TATTTGGATCAAGCTACTGTGTACTGGCTCCAGAGCATGCACTTGTTGCTAACATTACAA
+CACCAGAACAAAAAGAAGCTGTAGAAGCTTACATTAATTCTGTAAAAATGAAGAGTGACC
+TAGAGCGTACAGAACTTGCGAAAGAAAAAACTGGTGTATTTACTGGTGCTTACGCAGTTA
+ACCCAGTAAACGGTGAGAAATTACCAATCTGGATCGCTGATTATGTTCTTGCAACTTACG
+GAACAGGTGCTGTAATGGCAGTTCCAGCTCACGATGAGCGTGACTATGAATTCGCATCAA
+CGTTCAATCTTCCAATGAAGGAAGTTGTAAAAGGCGGAGACATTTCGAAAGAAGCATATA
+CAGGTGATGGTGCGCACGTAAACTCAGCATTCCTTGATGGTTTAAATAAAGAAGAAGCAA
+TTGTAAAAATGATTGAGTGGCTTGAAGTAACAAGCGCAGGAAATCAAAAAGTAACGTACC
+GTCTACGTGACTGGTTATTTAGTCGCCAACGTTACTGGGGTGAGCCAATTCCAGTAATCC
+ATTGGGAAGATGGTACAATGACAGCTGTGAAAGAAGAAGAATTACCATTAGTTCTTCCGA
+AAACAGAGAATATTCGTCCTTCAGGTACAGGTGAATCACCACTTGCAAACATTGAAGAGT
+GGGTAAATGTTGTTGATCCTGAAACTGGTAAAAAAGGTCGTCGTGAAACAAATACAATGC
+CACAATGGGCTGGTAGCTGCTGGTACTACCTACGCTACATCGATCCAAACAACAGCGAAG
+CACTTGTAGACCCTGAAAAAGTAAAACAATGGCTTCCAGTTGATATTTATATCGGTGGAG
+CAGAGCACGCTGTACTTCACTTACTATATGCTCGTTTCTGGCATAAAGTATTATATGATA
+TCGGTGTAGTTCCAACGAAAGAACCGTTCCAACAATTATTCAACCAAGGTATGATCTTAG
+GTGAAAACAACGAGAAAATGAGTAAATCAAAAGGTAACGTTGTAAATCCTGATGATATCG
+TAGCAAGCCACGGTGCAGATACACTTCGTCTATACGAAATGTTCATGGGACCATTAGATG
+CTTCAATCGCTTGGTCTGAAAATGGTCTTGACGGAGCTCGTCGTTTCCTAGATCGCGTAT
+GGCGCCTATTCATTCAAGATAACGGTGAATTAAGTGAGAAAATTACTGATGCACCAAACA
+AAGATCTTGAAAAAGCTTACCACCAAACAGTGAAGAAAGTAACAGAAGACTATGCAGAGC
+TTCGCTTCAACACAGCGATTTCTCAAATGATGGTATTCATCAACGATGCATACAAAGCTG
+AAACACTTCCGAAAGAATATGTAGAAGGTTTCGTAAAAATGATTGCACCAGTTGCACCTC
+ACATCGGGGAAGAACTATGGAGCAAGCTTGGATACAATGAAACAATCACATATGCAAGCT
+GGCCAACATTTGATGAGTCTAAACTTGTAGAAGATGAAGTTGAAATCGTTGTTCAAATTA
+TGGGCAAAGTTCGCGCAAAATTAACAATGAGTAAAGACGCATCAAAAGAAGAAATGGAAC
+AACTTGCACTTGAGGAAATCAAAGAACAAATTGAAGGGAAAACAGTTCGTAAAGTAATTG
+TTGTTCCTGGAAAACTTGTTAACGTTGTTGCAAACTAATTAATTATTAATAAAAGCTCAG
+AGCGTTTATGCTCTGAGCTTTTTTGCGTGAAAAATAAGCTCAGGATCACCTTCATCTAAG
+TTTTCGATCATTCCACTACGCATAAATCCATTTGCTTTAAAAACTTTTTGCATATTTGTA
+TTCGATTTGTTCGTTGAAGAAAATATTTTTTGAGTAGGAGAATGTCTTAACATATATGAG
+ATTAATGAGCTTGCATGACCTTGTCTTCTTTTCGTTGGCGAAACAATGATTAATGAGAGG
+AAAGTATGACCAAAGAAATTTGTATCGTATGTTAGAAAACCAAAAATGGAATTGTCCTCT
+TTTGCAATTATGCAGTTTCCTTCATCAATAGCGTGTTTAATATAATCTCGTCTACTATCG
+TCTCCGATTACATCAACATCTATATGTAAGATTGAATCTAAATCGTCGATGGAAGCTTTT
+GCTATGTTTTCCAATGGAAATGCCCCCTTTCAAGTGAAAGAAAAATAATCAGTCAATTAA
+TCCTATCATGAATGGAGAACGAAGAAAAAGGTGCGGAATTCCTATATAGACAAACACCTA
+TTCTTCTATAGGAAATATGATAAAAAAGGTAGGTTAAATTGAGCAGAAGAGGTGAAAGGA
+ATGAAAGGGATGGGCAATAATGCACCACATGGCTTCTTCGGAGGTGGATCGGATAGTTAT
+GGACAAATGATGTTTATGGGAGGAGATGGTCAACACGGATATGGCGGAATCCCAAGTTGG
+ATGGGAGGAGCAGCTGGAGGATTTCCGACGTCAGTGGCGGGTGTACAAACAGGATTCCCA
+ACATCAGTAGCTGGAGTGCAAACAGGATTTCCGGCAGTAGTAGGAGGTACACAAGGAGGA
+GTGCCTGTAGGTATGCCAACTACATTTCCATCTTTCGTTGGCGGTGTACAAACAGGATTT
+CCTGTACCTGGCGTTGGTGTTGTAGCTGGTGGAATCGGCGGATTCCCTCAAGGTGTTCAC
+GGTCATCATGAGCATCACGGCCATCATCATCATCATCAACACGGTCATCATCAGCACCAC
+GGTCATCATCAGCATCATGGCCATCATCAAATTCATCCGCAGGCTGTCCTTTATCAAACA
+CACCAAGGCCACCATCAGCACCAAGGCCACCATCAGCACCACGGTCACCATCAGCACCAA
+GGTCATCAAGATCATCACGGCCACCATCAGCAACAAGTACATCACCAAGGCCACCACCAA
+ATTCATCCGCAAGCTGTTCTTTTCCAAACACACCAAGGCCAACACCATCACCAAGGCCAA
+CATCATCACCAAGGCCAACACCATCACCAAGGCCAACATCATCACCAGGGCCAACACCAT
+CATCAAGGTCAACACCATCATCAAGGTCAACACCATCATCAAGGTCAACAGCATCATCAA
+GGTCAACAGCATCATCAAGATCAACACCATCATCAAGGTCAACAGTATCATCAAGGTCAA
+CAACAATACCAACAGTATCAGCAGCAACAACAGCCTTGGGCAGGTGGAATTGGAGCAGGA
+ACGGCAGCAGGAGCAGCAGCTGGTACTGCAGGAGCAGCAGGACACGCGGGACACGTGGGT
+CATTAATAGACCAAAGGAAAAAAGACATAATAAAAAACTGCTAGGAGATCCTAGCAGTTT
+TTTTCTGCCTCTTGACGTTGGCGTTCGATTTCCGCACGAAGTTGTGGTTCTGGTGCTTGC
+CATCTTTCTGGTTTCATAATTTTGCCGTCGCCCTCGCGGAATCGAGGCTTTCCATCAGGG
+AATAGTTTTGCCATGTTAGCATTGTTTACAATTTCGAATCCTTTATCTGGACGTACGCCC
+ATTTCTGCAAACGTTCCGAATGCAAAGTAAATAAGGTCAATAAGTGCATCATATTGATCT
+TCAACAGTTGTTGCTTCTAGAAATTCTTCTAGCTCTTCTTGCATAAAGCTAGCACGAATT
+TTTGCACGCTTTTCTGTTAGTTTTGTTGGAGTACTTGTCACAGGATGTCCGAATTCTTCA
+TGCATTTTTGCAACAAGTTCGTATCCTTTATCTAAACCTTTTTCGTTTGTCATGTTGTTT
+CATCCTTTCTTACGTTATGCCGAATTTTATCCCGCATTAACGGGCAGTAAGACTCCCACC
+TCAAAAGTCGCAAATGCGAGGAAGTGAGGTGGGAGATAACTGCCCGTAAAAGCCCGATTG
+GTTCAACTAATAATCAGTGGGGAATGGACAAAATCCCCACTGATTAAAGTTTCACTTTAT
+TGTAACATAAGGTAGTTATTAAATAAAAAGAACATCTTATGAGAAATAAGATGTTCGCTC
+GTTATTCTTCTTTCTTAATTAAAACGGATAAAATAAGATCGATGCCAAACATTCCGATGA
+GTAGCATTGGTATAACTACAAGTAAATAACGTGTGAAAGAAACATTTTTTAAGTATGTAT
+GAGCAAATAAAAAGACGCCGAGAAATAAAATACCATTTAAAATAGGTTTTACTAATTTTT
+TAGACATAAGCTCCCCCGTAAATATCCCTTTTCTCTATTTAAAAATAAAAACTCTCCTCT
+CCGTTGTACCATGCCAGAGAGGGGAGTTCAATCATTAACTTATTCAATTACACCAGAATT
+TGTAATATTGACAGTGTATGTCACCTTAATAGGAACATCTTTATACATTCTTCGCCACTC
+TTCTAATTTGAATGGACGGTAATGTTCTTTATACCTTGCGCCGAGACCGAGTGGATCCAC
+ATTCAAAGATTTAAACTGTTTAATTAGTTTATTAGCTTTTGCACCTAATTGTTTTTCAAC
+TGATTTTTCTATTTTTTTTGTGTTCTTTTTATTTTCTAAGTTGAACTGTTTAGATAGTTC
+TTGAATACGTGCTTCTAGTTTGACGTGTATGAAAAATGATGGTTTACCATCTTTAATACT
+TACTTGGTAAGTTGGGACGGATCGAATATTATTAATGATTGTGTATCCTGAGTTTGCTTT
+AAATTCATGTGAATCTAATCGGTGTTTTTCCAATAAACCTTTAAAGGCAAACATATCATG
+ATAACTAATTTTGCCAATATATTTATCTCCTTTTAAAAGGCCGATGCCAGTAATTTTTAT
+TTTATCTTTATCTTTTTTGAGAATTGGTAAATAGGAATCTTGGCCTTCACGATAATATCG
+ATAGGCTCCTAAATGTAGATTGTCAGTAGGTAAAGGACCCGTTTTCATATTATGGTCTAA
+CATTTTCTTTATATAAATTGCAACGTTAGATGATGTTGTATATTTACCCTTTAGTAAGTC
+TAGCCCTGTTCCCTCTAATAAACCGACATACATAGAGTTCCCGATATTCACATCACGAAT
+TAACGTGTCAAAGGAAGTTGACAACCCTTTTTTAGCAATTTTTGTAGTAAATAAAGCAAT
+ACGCATTTGTCCACTTGCAAACGGTTGAGCGGATTCTAAAGAAGTATCCGCTTTTACTTG
+TTTTACTGCGTTTCCTACGCCTTCAAAGACTTGAACTTTATTACCTTTTTTCTGTATAGG
+ACATACGAATGTGACTTTTACTTTATTATCTTT
+>NODE_14_length_39993_cov_63.1132_ID_27
+ATTTCGGTACGGCCTAAACATGGCAAAATAAGCGCATCTTTACCACACACCAAGTGGCTA
+CGATTTAACTTGGTTGCCACATGTACGGTTAAATTACATTTTCTAAGCGCTTCTTGTGTA
+TAAGCGGTGTCAGGTGTTGCAACGGCAAAGTTTCCGCCCAAACCAATAAAGACTTTGATA
+TCACCTTCGGCCATGGCTTTAATGGTTTCAACTACACCATATCCATTTTTTCTTGGTGAT
+TTAATACCGAACACACGGTCAATATTGTCGAGAAGTTTCGGGCTAGGGAGTTCATTAATG
+CCCATAGTGCGGTCGCCTTGCACGTTACTGTGCCCGCGAACCGGACAAAGCCCTGCACCC
+GGTCTACCAATTTGACCACGCGCCAACAATAAATTTGCCAGCATATGTACGTTAGCAGTT
+CCGTGACGATGCTGGGTAATCCCCATACCCCAACAGAAAATTGAACGCTCTGACTCTAAA
+AAGAGTTTAGCCAGTTTTTCTAAATGTTCAGGTGACAGACCTGAGTGCTTATAAAGATCT
+GCCCACTCCGTTCTTTCGACCTCAGCAATCATTTCGTCGAAACCAACGGTATTGACTGCA
+ATAAAGTTTCGGTCAAAAACGCTTGGTTTACCTGAGGCAAGGGCCTTTTTATCCCACTCA
+TGTAAGTGCTTTAAAATACCTAACATCAGTGCATAGTCGCCGCCAATTTTAGGCTGGAAA
+TAATAGCGACTAATTGGCGTACTGCCATTGGTCATCATTTCAAGCGGTGCTTGCGGGTCT
+TGGAAACGTTCGAGACCTCGCTCTTTAATTGGGTTAATCGCAATAATGTTACCGCCGCGT
+TTAGACACTTCACGCAAAGTACCTAACATACGTGGATGGTTGGTGCCTGGGTTGTGCCCA
+AAACTAAAAATGGCGTCGGCTAAATCAAAATCTTCTAGGGTGACTGTACCCTTTCCTAAA
+CCAATCGAGTCGAGCAAACCAACACTTGTGGTTTCATGGCACATGTTTGAGCAGTCGGGA
+AAGTTATTTGTACCAAAGCTTCGCACAAACAATTGATATAAAAATGCTGCTTCGTTACTG
+GCACGGCCCGAGGTATAAAATGCAGCTTGGTCTGGATGATCTAGCGCATGTAAATGTTGA
+GCGATGAGTTTAAAGGCATCGTCCCATGAAATAGGCACATATTTATCGGTTGTAGCATCA
+TAACGAACTGGGTCGGTTAAGCGGCCTAGGTCTTCTAGGAAAAAGTCACTTTGTTCTGAT
+AACCAACTGACGGTATGCCCTGCAAAATATTCGGGAGTGACGGTTTTACTGGTTGCTTCA
+AAAGCAACCGCCTTTGCACCATTTTCACAAAAGTTAAATGCGTGAGCGTCTTTCTTTTCT
+GGCCATGCACAGCCGGGACAGTCAAAACCTGTAGGCTGGTTAATGTTGAGTAAGGTAATT
+GAACCTTTACCTAAAATATCTTGTCGCTTTAAGTTACGAGCAACACTTAGCAGTGCACCC
+CACCCGCCAGCAGGATGAGTATATGGCTCAATTCGCGCAAAACCGTTATTTTCCTGTATG
+TGCTTTTGTTCTTCTGAATTATCCACTTTTTCATCCTCTTATCTTTTTTACACTCAACAG
+GCTCAGTGAAATCACAATTTAATTATGGTTTTATCAAAGCTACCCGCTGTTTACCGATGA
+GTAGAGTCCACTTTTTATATTATTGCCACTATGCTAAAAGCCGGCTCAACCGTTCTTATA
+ATATGTGCCATATTCTTTACAATTACAATAATTCAAGCCAACCACGTTATTTATATAAAA
+ACATATAAATCAAATAGTTAAATAGATATTAATTCTATCTTTTACAGATAAAAACATTAT
+TGGGTTTCATTTTTAACCGACTGAAAGCTTTTTAAAATTGACACTTACACGACTTTATCT
+ATGTTTTTTTCGCATTAAGCAGTATAAAACAATTAAAAATTTATCTGCATTAGAGCATTT
+ATGAAGGTTGTGATCGCCCCTGATTCATTTAAAGATAGCTTATCTGCTTTAAAGGTAGCT
+CAAGCCATTGCCAAAGGATGGCAAGCGGTTTTTCCCGATGCAGAAACGATTTTGTGCCCC
+ATGGCAGATGGCGGTGAAGGAACCATTGAAGCAGTTTTAGAAGTCTGCGATGGACAATGG
+CGTGTAAAAACAGTGGTTGGACCATTAGGTCAGCCTGTTCAGGCCAAATGGGGTTGGTTA
+GAAACACAAAAAATTGCCATGATTGAAATGGCTCAAGCGAGCGGCATACAGTTAGTTCCA
+CCGTCTGAGCGTGATGCCTGCCACAGCACAACGTTTGGCACAGGTCAGCTCATTTTGGAG
+GCTTTAGACGCAGGCGCAAAAGACATTATTTTAACTGTGGGCGGTAGTGCGACCAATGAT
+GGCGGCACAGGCTTACTTAGTGCTTTAGGTGCAGTTTTACTCGATGCTAACCAAAAGGTT
+TTACCCGCTGGCGGCCTTGCCCTTAGCCACCTATCCAAAATTGATTTAACACATTTCGAC
+TCACGTATTCAGCACACACGGTTTTTACTAGCTGCCGATGTGACCAATCCACTTTGTGGC
+CCAAACGGCGCATCACATATTTTTGGCCCACAAAAAGGGGCCTCTCCTGCTCAAGTCCAG
+TTACTCGATGCAGCCCTTGCCCATTTTGCTGATGTCACGGCACAATTTTTAGGTTTCGAC
+AAACGAGATGAAGCGGGTTCTGGGGCTGCTGGTGGTTTGGGCTTTGCCGCCAAAAGTTAT
+TTAAATGCAGACTTTAAAGCTGGAGTTAAAGTTGTGGCTGAACTGAATCAGCTTGAGCAT
+AAAATTTCTAACGCAGATTGGGTAATTACGGGTGAAGGTAAATTTGACCAACAAACCTTA
+AGCGGTAAAACCGTTTTTGGGGTAAGCCAAATTGCCAAAGCCCACAATGTTCCGGTCATT
+GTGATTGCAGGGACTTTAGGTGAAGACTACCAAGCACTTTATGAGCACGGCGTAAGCGCT
+GCTTTCTCACTAGCCAATGGCCCCATTACCCTAGAACACGCCTGCGAACATGCAGCAGAA
+CTCATTTATGAGCGAACAGTCGATATAGCGAGATTAATTCAGTTTAGCCAAACCAGCTTA
+AATGCTAAAAAAGTCTAATCGGCTAATTTTAAAAGACTCTCTCTACAACTTTCCAGGATT
+TCATCGCTAAGGTTTGATTGGTCTGGGCATGCACGAGACAATGCAATTGCCCCTACTGAC
+TGAGCAAGAATATTAATAGCTTGCTTTCTCAGCTCTTCTGTTTCTAAAGAAACTTGTTTT
+GCGCGTTCATTCATAATGAACTCAATAAGCTGCTCAATACCCTCTTCAAACTTGACTTTT
+ACTTCGTCGGGCTGTCTAGCGGCATCACAAGATAGCGCTGTTAAGGTACAACCCTGATCT
+CGGTTGTCTCGATGTGTACGAGACACATACATATGAATAAATTGGGTTAAGTTTAAACCT
+TCTATTCTTTTTAAAACCTGCTCAAGACCATGTTTGGCAGTAATAGTAACAAGGTCTGTT
+TTCGAGCTGAAATGTTTATAAAACCCACCATGAGTAAAGCCTGCGCTAGACATTAATTCG
+GCAATGCCCACCCCGTCGTAGCCTTTACTACGAAACAGTTGAGTCGCCTTTTCAACAATT
+TTATCTCGGTTTTCTTTTACCTGAGTTTTACTGACTTTCATGTTGGTGCGCTCACTTTTC
+TTCGCCCTGCTCGTCATTATTATACATTGATTATGATTGACATCAAAACCTGTATATTTT
+AGATTATAATCATCATCTAAAAAATTAAAGCGTGGAGACATCACATGTCATCTCAATCAA
+AAGTACTTATTACAGGGGCTTCGTCAGGAATTGGTTCTGTTTATGCAGATCGATTTGCTC
+AACGTGGCTATCACTTAATCTTGGTGGCACGAGACACCCACCGTTTAGATAAAATTTCAA
+AAGATCTTCAAGAAAAATACGGTGTACAGGTCGAGTTCATTCAAGCCGATTTATCAAATG
+ATCAAAACATTTGCAAAATTGAAAATGTACTCAAAAACGATGCTGATATTGAAATTTTGG
+TAAATAACGCTGGGATTGCCCTGAACGGAAACTTTTTAACTCAAGATCGTAATGAGATTG
+AACAACTTCTAACTTTAAATATGACTGCGGTAGTGCGGTTGTCTCATGCAATGTCGCAAT
+CCCTTATACGCAAAGGTAAAGGCGCCATTATTAATTTAGGCTCTGTACTTGGCTTAGCGC
+CTGAATTTGGTTCTACCATTTATGGCGCAAGTAAATCTTTCATCCAATTTTTTAGCCAAG
+GCTTACATTTAGAGCTAAAAGATCATGGGGTACACGTTCAAGCTGTATTACCTTCTGCCA
+CTAAAACCGAAATTTGGGAACGTTCAGGTATAGATTTAAGCCAAGTTCCGCCATTAATGG
+ATGTCAATGATTTGGTCGATGCAGCCCTGATTGGTTTTGATCGTAAAGAAACAATTACAA
+TTCCTGTGCTGAAAGATGAAAATCAATGGAATAATTTTGAAAAATCGCGTATGACATTAT
+TACCAAACTTCTCTTCGGCTGAAGTAGCCCAACGTTATAAAAACTAACGACTAGGGCTAC
+CCAACTCTCAAGTAGGAAAATCTTATGAATGTTATTGATGCTCTCCGCAAACGCCGTGCA
+GTTAAACGCTTCGACCCTGCTTTTCAACTCTCTGAAGATGACAAGAAGCAGTTATTACAA
+GAAGTTTTAGCAAATGCACCAAGCGCTTTTAACTTGCAGCATTGGCGTCCAGTCATTGTT
+GAAGATGCAGAGTTAAGACAAAAAATTCGCGCGATTGCTTGGGACCAACCACAAGTAACA
+GAGTCATCATTACTGATTGTGTTATGTGCCAAAGTAAATACATGGGAAGTTGACGCTAAA
+CGTGTATGGGATGGAGCTTCTCCAGAAGTTCAAGATATTATGGTTGGTGCAATCGACCAG
+TATTACCGTGACCGCCCACAAACCCAACGTGACGAAGTGATGCGTAGTGCGGGTATCTTT
+GCTCAAACCCTTATGTTACTTGCTCAAGAGCATGGTTTAGATAGCTGTCCAATGGACGGT
+TTTGACTTTGATGCAATGGCAAAGCTCATTAACTTACCTGAAGATCACGTGGTGTGTTTA
+ATGATTGCGGTTGGTAAATCAGCTTCTGAACCTTACCCGCGCGTAGGCAAACTCCCTTAC
+GATGATGTCATTATTAAAAATACATTCTAAGTTGTAATTCAAATTTTAGGCTTTCATTCT
+ATTTTTGTTTTTATACTAAATAGATGGAAGCCTTTAATTTTGCATTAATTATAAAGCTGA
+CTTTGACTCGGCTATAAACTGTCTCAAAAAGCAATTTAATAATCTCTCCCTTTCATCCGC
+GTACTCTGCACTCAAAAGCTGAATGATTGTGCCTTCCACCATATATAAAAATAGTTTGGC
+ATCGGTAAAAGAGACATCGGGTTTAAGCAATCTAAGCTGGCTATAAATCTCATTTTTTAG
+CCATGTTCTATAGCGCACTGCGGTTTGATAAGCGTTGGGATAGCTATTTTTAATTTCAAA
+AACGGCTTTAAATAATAAGTAATACGGCCCTTCTACATCGGTATGTAAGTCATAAAGCTT
+TTTGAGTTTATCGATGGCAGGAGTGCTTAAGTCATATTCGACCATTGCGACTACTTGTTC
+TTGGAGCTTTTCTTTTTGCACCATCAGGCAGATTTCAATAAGCCTTTCTTTAGAGTGAAA
+GTAATTATAAAAAGTCGCTTTTGTAATCTCTGATTCTTTCACTATTCTGTCGACCCCAAT
+AAGGTGAAACCCACGGTGGTGAAACAGATCAATTGCTTTATTTACAACGTATAAGGCACG
+TGTTGGGAGAACTAAATTTGGCATAGTTTTACCGTTATAAATTCTTGTTGTTTGTAAATG
+AGATACTTTTTTGGGAGAAAAAAAGGCACAGCAAAGCCTATAAAGACTGTGCTTGGCACA
+TCTCAAGTTTTATTGTTGCTAAGTTTTTGGTTGTGACGATTTAAAGCCTGAAAGCGCTAA
+TGGCCCTCAAACTGCTTTAAAGCTTATGTGGTGTCGTTATAGCTTTTGGCATTGAGAGCC
+AAGAAATAATGTATGTGCAAAGCCAACTCCTTTTTATTGGGAGTTCTGCCAGACATGAAT
+AGGAATTATGGTGGCAGAACGGAAGAAGGTTGACAGACTAGTATTATCTCAAACTAGCAC
+ACCCGTAGGTGTCCCTCTCCCGTCCTACCGCTACGGGAAAGGGACGAGTAGTACACCACA
+CAAGACTGTTCCTCAGAAGGAAAAGCTCTGATGCGGGAGATAATATTCAGCCTGTCAAAG
+CCGGCTGGCAATGTGGCCAGCAGGCAAAGAATAGTGCTCTGCTCTTTAGCAGTCAAGCAC
+ACAAAATGACATTTGTTTTAAATTAGATCATTAAAAAGTAAGGATAAATAATGAGATAGT
+TATTGTTAAATGGGGGTTTATAAAGGGGAAATAAAAACAGCCTAGAAGACAACGATCAAA
+AAAATGAGGCTTATTATAAGCCCCGTTCCGTTAATTATCTTGTATCTTCACTAGGGTTCG
+ATGTTGATGAAGTACTATTCTTTGATTCTATTTCAGTTGCTTTTGGAGTGATTGCTATTA
+CAGCTTTACTAGCAGCATCTTTAATTTGTTCGGCCACTTGACCCGCAAAACCTGGTACTG
+TTTGGGTCGCCTGTTTTACTATATCTGATGAAAACAATTCATGCCACGGACTTCCATGAT
+TTTCATTCTCTACAAATCTCAGTGGCTGCTCATCTAGGCGTGATAAAGCCGATGCCAAAA
+GTCTTGTTTCCATATTCTTATCAACTCTAGCAGCCTCTCTACTATAGCCTTCATATGCAC
+GAGATACAGAAGCTTTAAATGCATAATCTTCAGATAATCTAAAACGCTGGCCTATTTGTT
+TTGTTGCTAACCAAGAAAACCAAATTGGAGCGCCTAAAGATAAAAGAGAAAGAAGTAAAT
+TAATAAAAATAATGATCGTTGAGCTATGAGTATCTTTTAAAAGCTCAGATAGGCTTGATA
+AACGTTGAGAACCAAAATAACCTCCAACTCCTAAAGCAAAAATTAGGCCTGCAACCCACC
+ATTTTATAGACCTAGACAAGATATTCGAACGTTCAGTAAATGCCGCTGCCAATCCAACAC
+TTGTTGCTGCTGAATATGCAGTTTCACAGCGTTCTAACACATTTTTAGCATTCAAAGCAT
+AATTATTAATTTCTTCATCAAGTAATTTCGAATTTTGTTTTAATAGCTCAATTTCTTTAT
+TTTCTTTCATTGAATCTGAAAACAAATTATTAATTTGTTGTCTCGCTTCCTTTAAAGAGG
+CTAAATCAGTCGGTAATTGTTCAGCTGCCTCCGATGCTTGTTCAATTCGTTCAACCATTG
+AAGTCAAAGAGTCTGTGCGAGGTTCTACTTCATGTATTTTTGCTTCAATAGAGCGAATAC
+GAGCATTTAATTTTTTTAATTTTGTTAAAGCTTCAACTTGGTCAGCAGCAAGTTTATTTG
+CATATGGAACTAAAATAGACTCAAGTAAATTTTTAAGGCTATCAATAGTGAATAAATATG
+CTGGAATTGCTAAATTGACGTTAGATGACCACATTTGGGGAATGGTATGACTAACAAGAT
+ATTCTAAGCGTTTAATATAATTAGATATAAGAGCATCTTGATTCTGATCCAGTTCATCAG
+TTTCATAATTTTTAATAAAATCAATAATATGTTTTGATTTAGAAATGAGTTCTGTTTTGT
+TTAAGTTAGGACTACCCCAACTATTATGTGTTTGTGCTAAAGGCTCATTATTTTGAATAA
+CGTTATTAAGTTGATTATTAACTGCTTCTAATTGCTGTAATATGTTTTCTAATGTAGCGT
+GCATGACTAACCCTTTCATTGGCTTTAAATTATTTTATTTAAACAATTATAATACATATG
+TAGGCTAGAAAGTGAACAAAAGAAAATAATGTGACATGTCATTCAATAGTTTCTATCAAA
+TATAATAGACAATATAGATAAAACGGGATTTTCATATTAAGGTCAAATAACCTTTTAGTG
+TTGTCTTTAACTTTATATTTATTAGACAGCAAAATTTATTTTTTATACAGCAACAAACTC
+ATTTTTTTAGTACTTATGTGATTTATATATTTTTATAGACAACACTAATATTTAGTACAT
+TCTTTATTAATGTCCAAAATTAACTATAGCTTAGCTACAAAAAAGCCCCTGTTCTACAGA
+GGCTTTTTTCAATTCAACAACGTATTATTTATGAACCCAAGGCACAGCCGGTGAACCAAT
+CCACGCAGATTTAGCCGGAATATTTTCACCTTTCATGACCAGTGTTAATGGCCCTAACAC
+GGCATGATTGCTCACGTTTGCGTTATACAAAATAATACTGCGCGCATTGACCACTACATC
+ATGCCCCACGTTCACTTGCCCGATTTTCATAATACGGTCTTCAAACAAGTGAGTTTGTGG
+GCCTGAAAAACTATTAAACTCGGCACGGTCACCAATGCTGACACAGTCAAACTCGGTAAT
+ATCAGCCGTATCCATATAAACGTCTTTACCAATACGAACCCCTAAAATACGCAAGAAGAA
+TGGCAACATTGGCGTTCCTCTTAAGTAGTTTAAGAAGTTAGGAATCGCAACTGATTCATA
+TAGGCTGGTAATCCCTTCACTTAACCATACGAACATGGTCCACATAGGTGCCGAACACGG
+TTGATAGCGACCAATCAAAATCCATTTTAATAGCGCAACAATAAGGAAACAGCCAACACC
+ATAAAGCAGCCCTGCGAGCGTTAATGCAACCAGTCCTGTCTCAATATTGTAGTTATTAAT
+CACATCAATAACGTCTAGCACGATCATATAACCCACCCCAATCGCAAGTGCGGCCGGCAA
+TACAATACGAAGCCCTTCAATAAAACCGCGCATTAAACGGCGCTTAATACTTGGTTTAAA
+GGTTAAATGGTCAGGATATTTTTCAGCAGCTTCACGTGCAGGTAACAGCAACGCCGGAGA
+ACCAAACCAAGTTTGTCCATCATACATTTCACGGTTATCTGGTGTTTTTGATTGCACGCC
+AATTAAAACATTGTCTGGTAACACTGCCCCATCAGCAATATAAGCACTATTTCCCACAAA
+ACTACGGTTACCGATTTTGGTTGCTTTTAAAGACATCCAACCGCCTTTAATCTCTTCATC
+ACCCAGCATTACCGCATCGGCAATAAAGCTTTCTTCACCCAAAGTCAGCATTTCTGGAAT
+GACACCAGTTGCGGTAGAAATTTCGGTATTTTTACCTACTTTTGCTCCCAGCATACGAAA
+CCATGTAGGCGCATAAATAGTGGCAAACAAGCCATGTAAGGTTTGTAAACTCGTCTCTAA
+AATTTGGGCCGCAAACCATTTACGATAATACGTGCTGCCATGAACTGCATAGGTTCCGGT
+TTCAAGACGCGGCAATGCAATTTTACGCAGACCTGAAGAAATCACCGCAGTAATCATCAT
+CATCATTGCACTAGCCGGAATCGCTAAAATGAAATAGTAAAGCGCGATTTGCAAATGGTT
+GTTCGGGTTAATATTAAATACATTTACATCTAACCAGTCGACCAAAAGGAAGCTTGGAAA
+AATTGGAATAAAGAAAAGACAGGCAATAATTAATGCGCTAACGCCATAGTATCCATATTC
+AGCAATTTTACGTATAAACGATAGTTTAGGACGCTCTGGCAATTTAGCTTGCTCATCTAT
+ATGCCCTATTTTCTGAGCAGGTGTTCCATCCCAAATTTCGCCCTCAGGTACAACCGTGTC
+ATATTCAATTGAAGTTAAGGCATTTACATGAGCTTGTTTTTCTAACACTGTATTTTCTTC
+TAATACAGCATACGAACCTACATAACTGTCTTGTTTAAGGTGAATTGAACCTAATACCAA
+GTGACCATGTTCAACTTTGGCATTTTCTAAATTCACCTGAGAACCGATACTCACGCCATC
+TTCAATAGTCAGTAAAGATGGCATACGAATATGTACAGAACTAATGGTAACGTCGTGACC
+GATTTTTGCACCAAGTGCTTTCAAATATAAGTTAAGTAAAGTCGAACCCGACAAGAGATA
+GACAGGTGAAATATTACTAATACGGTCCGCTAGCCACCAACGGAAATAGGTTAATCCCCA
+TAATGGATAACGCCCTGCGCCAATTCCTAACATTAATAGTCGTTTTACCGTAATCGACAG
+TACAAAACTGCTCATAATGACACTGACATACACCAATAAAGACAACGCAATCGCATACGG
+AATACTGTCGCGAGTTCCACCGGTAAAGTAGTGATAGGTAAAGAATGGCGCTAACCACTG
+CAAAATATTAATCGAGATTAAAACCGGAATAGTTACAAGCTGTGCAATACCACATAACCA
+TTTATAGGTCTGATTACAAGGGTTATCTTGTCCAATTTGGCTATCAAATAAAGTAGGTTC
+AGGCTGCTCTAACATGAGTGCAGCAATCGCGCCTACTCTTCTCGCTTGATATAAGTTTTG
+AATGGTCAGATGGCTATATTCCGCATGCTCACGCAGATTTGAAATTAAAACAGCGGCAAG
+TAGTGAATGCCCGCCTAAATCATCAAAGAAATCAGAATCGAGTTTAATCGGCATGTTTGG
+GAACAAACGATTCAAAATTTCAAATAGGATTTCTTCGGCTGGGTTCTGTGGCTGATCAGA
+TTCACTGCGATCTACCACACTTGTGAGCGGTCTTGCTTTTAAAGCTTTACGGTCAATTTT
+CCCAGATAATAGACGTGGAACTTCTTCAATAATCTCAAAACGATTTGGCACCATATAAGG
+CGGTAATCGCTGACTCAAGTTATGGCGTAGTTCTTTAATTTCTATAGCTTGCTTTGCATC
+AATTTCTGGTGCAATAAACGCAATAAGCTGATCAATGCCGTCTTCAGGACGAAGAATAAC
+GGCTGCCGTACCAATTCCGTCAATATCGCAAAGCGCAGCTTCGATCTCGCCAAGCTCTAC
+ACGGAAACCACGGATTTTAACTTGGTCATCGGCACGACCTAAACAGTGTACTTGACCAAA
+CTCATCAATTTTAGCCAAATCCCCAGTACGGTAGAGTAATTCTTCCTCTATACTCATTGC
+CCAAGGGTTCTCAATAAACTTATCTGCGGTTAAATCAGGTCGTCCTAAATAGCCTTGTGC
+CACACTTGGACCAAAAATACATAACTCCCCTGTTTCACCTTGCTCGAGCAACTCTCTTTC
+AGAGTTAATGACCAACATACCGTAGTTTGGTAAGGGCTTGCCAATGGTGACAGGTTTGCC
+GCGTTCCAATAACTCAAGACTTGCAGAAACCGTGGTTTCGGTTGGTCCATAGGTGTTAAA
+CATTTGATGATGAGGTAATGCCCAGCGGTCAACCAGTGAGTCCGGACACATTTCCCCACC
+TAAATTAATAATTCTTAAATTAGGTACGTCTTCAGGAAATAAGGCAAGTAACGTTGGAAC
+AGCATGCAGTACTGTAATTTGTTCCTGCTTTAAGGTTTGGCATAACCGCTCAGGGTCACT
+GACAAGTGACTTCGGTGCAATCCACAACGTTGCACCTACCAAATAAGAAAGCCAAATCTC
+TTCAAACGACATATCAAAAGCGACTGAAAAGCCTTGATAGACCTTGTCTTGCTCTTGAAT
+ACCCAAGATACTATTTTCACTACGTAAAAAGTGACAAATATTTTTTTGAGTAATCACAAT
+TCCTTTGGGTTTACCTGTCGAACCCGAGGTATAAATAATATAGGCAGGTTGATCTGGAGT
+GGTTTTCGCTAAACTTACACTTTCGCTTAATGGTTTTTGCAGCTCGGTGTTGGTCCATTT
+TGTTTGCGGCACTTCAGCTAAATGTTCATACCATTCATCTGTAGTAATCATTCCCACCGC
+TTCGGCATCTTCAAGACATACCGCAATACGGTCCGCGGGCGTATCCATATCAAAAGGAAG
+CCAAGCTGCACCGCTTAAACAAATGGCTAGTTGAGCTTTTAAAAGCTCAATACCACGCGG
+CAGCCATAGCCCTACAATATGACCTGGCTTTACCCCTTTTAAAGCCAGATGTTGAGCCAT
+AATTAAGGCTTGCTGATACAGCTCACCATAACTCAGCGTTTTATCTGCTTCAATTAAAGC
+CGTTTTATCAGGAAGAGTTTGTGCAGTATGAGCAAAAATATCGGCTAAGACTTCATTCTG
+CAAAAATTCCGGATGATACTTTCCACGAATTACATTTTTCGTGTTCGTTACAAACTGGTT
+CATTTTTATACTCTCTTAATTTTCTGATTTGGCTTAAATGAAGTCATAATTTATTTTTCT
+GACCCATTAACGAAATCTAGATAGGCCATAAATTAATTAAGAGAACTTAAAGCAAGATTA
+AATTTTTTAGTTTTGATGTTTATTCAACAGAGTAAGAACCTTAGCCTCTAATTTTAAATT
+ATAAATAAAAATCAAATATTTAATATTATTATTCAAATTTTATGATTATCTTTAAGATAA
+AAACGTACAAAACTAATGAAGTAAAAAGCTAGAATTCACAAGATTTATATAGTTCTTGTT
+TTAATTAAACTAATAAAAGCCATCCTGTATACAAATTCTCCATATTTTAAACTTAATTGT
+TTAGTTCTGAATTATTAAAAGAGTTCTTAAAAATAAAAGAGTTCATTTAAATTTATGCAT
+GATGTTTGATTATTAATATTATATTAAAATTGTATGCATCAATTCTTTTTAACTTATATC
+TTTATCTGGATTTTATAAAAAGTTAACTCCATTAAGCGGATTGAGCGAGCAGTTATTTAC
+ACGTTCTACTCATAACTCAACCTACCCTATTTGGAGTGGTGAGTTGTGTGGGTTAAAACG
+AAGATACTCTTGAAAGGCGAGCTAAGATCACCTGTTTCATTTAAGCATGACGAAGTATCT
+TTATTTATAATATTTGAAAATGGACTTAAAAAATTAAACAGTGGTGCTGGTATGAGTCAA
+CACATAATAACCCCAAAAGAAATACCTTTAGCATTTCAAACCGCTTGGAATAAGCATGAT
+ATGCAGGCCTTTGCTGCTCTTTTTGATAAAGATGCGACTTTCGTTAACCGTTTCGGTCAC
+TACGTTAAAGGAGTTGATGAAATTATTGCAATGCATCAACCTATTCATGGAACCATTTAT
+CGTGATTCAACACTAGAGAATGAGCTGATAGACCTCATACCTATGAGTGAGGATATATGT
+ATTTCACATTTTTGGAGCCGCCTCACTGCAGGCGTAGCTCATCCTCAAGGGCCTCATCAG
+ATTGATACTCTCATTCTTACTGTGCTCACCAAGAAGAATCATTCTTGGTACATTCAGGCG
+CTAGAAAATGTCACTTTGACGAACCCTCGTACGGGAGAGACCATACTTAGAAATATATAG
+AAAGGAGCACGATCATTTTTTTAGTAATTTATATGCATAAAAAAAAAGCCCTCGTCATTA
+ACAAGGGCTTTTTAAGAATTTTGGCGGAAGCGGTGAGATTCGAACTCACGGAGGACTCAC
+ACCCTCGTCGGTTTTCAAGACCGGTGCATTAAACCGCTCTGCCACGCTTCCAACGAGCGC
+TATAATATAAACAAAAATGCAAGTTGGCAAATCTTTTATTTAATTTTTAATTCAAACGCT
+CAAAATAAAAACAAATCTATCTAAATTTCATCATTTTTAGGTTTTTCATAGCGAATTGCA
+TTGATATACCACAGCTTTTTACCCAAAGGCGTGTGTACTTCTACTTCATCATCGACTTCT
+TTACTCAAGAGTGCACGTGCCATAGGTGACTCAATTGAAATATGCTGAGGATGGTGATCA
+TAAATTTCATCTACCCCGACAATTCGTAAAGTTTTTTGCTCCCCTTCTTCATTTTCAATG
+TCGACCCAAGCACCAAAGTAAACTTTGCCTTCTTGCTCAGGTGAGTAATCAACAATTTTT
+AACTCTTCTAAACGCTTTCCTAAATAGCGTACTCGTCGATCAATTTTTCTAAGGAGCTGC
+TTGTTATATTGATAATCTGCATTCTCACTACGGTCACCGAGGCTTGCAGCCCAATTTACT
+TTTTTCGTAATTTCTGGTCTTTCTTCATGCCAAAGTTGTTTTAATTCAGCAACTAATTTG
+TCATGGCCTGACCGAGTGATTAAGTTAGATTTCATGATTAAAAACCACTGATTAACAACA
+TAAGGGTTACAAGATGTAGCATTTTATACCCTATTTTCTCACATCAGAAGTGTATAAATT
+TTCTTCCTTAATAAATTCATGTTGTTATGATGATATATCGGATATTTAATTGTACAAAAT
+TTGACAATACTTTTTCTCAATATTATGATGCGCGCATCTTAAATGTTGAGTATTTTTTAA
+CCCACTCAAAATCTATGTAGATTTTCTACACAGTTTGCTTTTTTCATTTCATGTCATTTT
+GAATGACGTCATGACTGCCCACCCCTTATTGAATTTATCAACTTTTAGAAGTTATGGCAG
+CTTTTTGTCTGACTTTTAGGGCATAAATTACCTGTAGCGGAGACAACATGCACAGTAATT
+CAAGTTCTGGGTCGAGGCTTGGCCTTAGCTCTTTATTTTCTTCTCTCCCATTGAAAGTTC
+TTGCGCTCAGCACTATGTTTTTTCCCTTTCATAGTATCAATGCAGGAAAAACCCTACAGT
+ACAATACTGTAGTTAACACAAACACATTAACAGTAGTTGCCGTAGAAAGCCCAACGACTG
+TTTTTAAAGAAGACCAGTTTTTACACGGCTTCGGTTATGACTTAGCGCGTAACTATGCAC
+AAAGCTTAAATGTAAAGTTGGACTTCAAAATCGTGACAGACAATGCCACGGCACTTAAGT
+GGGTTCAGCAAGGTAAAGCAAATCTTGCCATGACAACCGCAAGCTTAAGTTCAATCGAGA
+ACAAAGGTTTAATGTCTTTTTCTGCAAGTTGTGGTGATATCGTAAATTTGCAAAAAAATG
+GATTAAATCCGAATCTAAGCTGGGTGTTTAAACAAGCAGATGACCCGCTTACACAAACAG
+CAAGCGGTTTTGTTTGTCAAAGCAAACAAAATGGTCTAACTCAGCAACTTGCTTCTTTTT
+ATAACCGTAATGTTGTAAAACCAGAAGCTTGGTCTACGATTCAACGTGACTTAAGTGCAC
+GTATACCGATTTACAAAGCAAGCTTTAAACAAAGTGCTGCTCAGTACGATTTAGACTGGC
+ATTTGCTTGCAGCGATTGGTTATCAAGAATCGTACCTAAAGCCAGAGTCTGTTTCACCAA
+CAGGTGTACGTGGGTTAATGATGTTAACCAATAGTACAGCTCGGGCAATGGGTGTGAGTA
+ACCGTAATGATCCAGCACAGAGTATTCAGGGCGGTGCGAAATATTATGATCTCATGTTAA
+GTGAGTATGATGATATTCCTTTCCCAGATCGCAACTGGTATGCGCTTGTGGCTTACAATA
+TGGGTCCAGGTGCAGTGAACCAGATTCAAAAGCGCTTGCAAGCCCAAGGGAAAGACCCGA
+ACCAATGGGTTAATCTCTATAATTATTTGCAGAGTAACAAAACTCGCAATGGTCGATACA
+AACAAGCAGTTCAGTATGTGACTCGTATACGTGCTTATCTTGAGCACATTAAAACGGCAC
+AAACGCGAATTAATATCTAGTTTTTATCATCTAAAAGTTGATAAATTCATTGTTTGTATA
+AATAAAAAGCTTACCTCTCGGGTAAGCTTTTTATATGAATTCTTTTTCAGTTTAAGCGGT
+TTGCTCTAATACTTTTTTGAACAAATCTTTTTGTTCTTGGCTTGGTTTAGCTGTTTGTAA
+AGCCATTAACTGAGACATATCGCCTTGAACTTTTATTTTACCAGTCATGAATGCCTGCAT
+AGCAGCTGCCATATCAAACTCTAGGAATACTTTACGTAAAGTTTCAGCATCCATGTTTAA
+TGTAGTTTTAGCATTTGAAGACAAACCTTTTTGGATTTTACCCCCATCTAACGCTAATTC
+GGTATTTCCAGAAGCATCTGTAACTACTAAATTAATTGCCAAATTCGCAAGAGCTGGTGG
+CAAATTAAGATCACCTGCTTCAGCAGTTAATTTTTCGACAGTCGCAAACCAATCATCAGT
+TAAAAATGCAGGCATGATTCTTCCTCAAATTTATTTGTTCAATTTCTCTAGTGTTGCCTA
+TCCAGACAACATCGTGTGAAGCACTTCTGCTTGAGCGTTGTTATAGCATGTAATTTTAAG
+GTTGAGCTATGACTTTTTGTACGGAACATTCATTTTTTAGTATTTTGATACATTAAAGGC
+ACTTGTTTATAAAGTGCCTTCAATTGACTTATTAATTCGTTTTATTCAGCAGCAAAGCTT
+AAGTTCACTACATCTAAACGTTTTTTCAGTTCTTCCGGATCTTTAAAGTCTAATTCGCGC
+TGCGAGTCAAGAACTTCGAAATCGAACAAATCACGGTCAGCAAGTTGTGAAGGTGAAACG
+TTCTGTAACGCACCAAAAATGCTGTGTAAACGTTTTGGATACTGTTTGTCCCATTCACGA
+AGCATTTCATTGATCATGGCACGTTGCAAGTTCTCTTGTGAACCACAAAGGTTACACGGA
+ATAATCGGGAACTTACGTAACTCTGCATATTTGATAATGTCCTTTTCTTCAACATAAGCC
+AAAGGACGAATCAAAATATTTTTCTTATCTGACGATAAAAGCTTAGGTGGCATTGCCTTT
+AAGCTACCGCCATGGAATAAGTTCAAGAAGAAAGTAGCAATGATGTCATCACGGTGATGC
+CCTAGCGCAACTTTGGTTGCACCAATTTCTTGAGCAAAGCCATAAAGCGAACCACGGCGT
+AAACGTGAACACACAGCGCAGTACGTTTTACCTTCAGGAGTTAAACGTTTGGTAATGCTG
+TAAGTGTCTTTTTCTAAAATGTAATACGGAATGTTATTCTCTTCCATATAACGTGGTAAG
+ACATCTTCAGGGAAACCAGGCTGCTTTTGGTCAAGGTTAACCGCAACAATATCAAAATTG
+ATCGGTGCAATACGTTTGAACTGCAACAAAATGTCGAGCAAGGTATAACTGTCTTTACCA
+CCAGACACGCACACCATGACCTTATCACCATCTTCAATCATATTGAAGTCACGGATGGCA
+TGTCCAACTTGACGGCGAAGCTTCTTAAGCAAACGATAATAGGCCGAGCTTGTTGGAAGT
+TCAGGCTTAAAATTAAATCCTTCGTTGGACTCAACTGGCGCGTACATAGACGAGATATAC
+CCATAAATAAAAATACCGCGCAATTTTATATGATTCGGATGAGAATCGCATCAAAAGAAT
+AGTTTCAATTCTTGAAGTCGTCATAATGCTCAGGCATGATGCAAAAGCAGTGCGCTATTT
+TGACCGATGAGTTCATTTTTTGCGCAAAATGCTTACTTTTTGGACTTTTCCACAGTTTTC
+CACAAAACCTGTGGATAAAATTGTGGATTTCTTAATACTTGACAAACTGTTTTGACCTTC
+TGTTAAGGGTTTTATTTAAATTGATCATTTTTTAACCAATGATTTTTACCCTTATTTTTC
+AAATAGTTATTCAAGTCAATAGAATCATTTTAAAAATTTTTTTTAATTTTTTTTGATGAT
+CATTCGAGCAAAACTGCTTGATTTTTTCAAAGAGTCAAAATAAAAAAAATTACACAAAAC
+TTCTTTAAGTAATATTTTTTGATAAACTCTTTGACAAGTTTTGAGACCCTAAAATTGTGA
+ATAACATAAAATGAAAAATTCGGTTCAATATCTTTTTTCTTGTTTACTGGGGATGACCAC
+TTTTTCGGTAGGTATAACGCCGACTTCAGCAGGTCAGATGTACATTTACCAAGACAAAAA
+CGGCAGTACTTTACTGACTAACCGTAAAAGTTATGACCATTCACTCAAAAAATTAAAAGT
+CACCTACTACCCGGATAGTAATATTCATAGTTATAGCAACTGGGGGACTTCAGAAGCTTC
+GGTTCTACCAAGCTATAGCAAAAACAAAAATGCTTTTGATCATATTATTAAGCAGGCAGC
+ACAACAGCATGGTGTTTCGGAAGGATTAATCAAAGCCGTTATGCATACCGAGTCTGGCTT
+TAACGTAAATGCCCGCTCTCCGGTTGGTGCCCAAGGTTTAATGCAGCTTATGCCAGCTAC
+TGCTCGTCGTTTTAACGTATCTAACGCTTATGATCCTCAGCAAAACATCTTCGCTGGTGC
+TAAATATTTAAGTTGGTTGCTCAAACGTTTTAACGGTAATACGCAAATGGCGCTTGCCGC
+TTATAATGCAGGAGAAGGAAACGTCGATAAATATGGCGGTATTCCCCCATTCCGTGAAAC
+CCAAGATTATGTTCGCCGAGTCACAAGCCGCTACCAAAACTTATATTCTTCTGGTGTAGG
+CCTTTCTTCTTTTAGCAATTCGAGTATTTCTGCCCAAGCGATAAACCAGCCAGCCATACC
+GCACAGTACTTCGACGCAAGTCTCTGCTCAGCCTATAAAGTATTCTTCCTCGCGCCAAAT
+CGTGACATTGCCAGATGGTACATATACAGACGCACCTACGGGAACTTATGTCACCAATAA
+TGCAACTGCTATTGCACATATCCGGATTGAGTAAGCTTAAAAGGCCTCATACCTTACGGT
+TACTTATTTAGCGGGTTCTATTATCAAAAAATTGTAATGATCTATTACCCCCACTGTCGT
+GTTCAGAGGGGCTCTCTAATAACTTGTTTAATTTAAATACATTCTTCGATCGCAAAGAAT
+GTATTGATTCCTTATTTTTTTCTTGAATTTTTCCCCTAAGCGCCGCATATTAGCTGAGTG
+ATTTATAATTTATAAATCAGATAATATTTTATTTATAAGAGGATTTTCTCAATGATGCGG
+ATTGGTTTGTTTTTGCTTACCAACCTCGCGGTACTGGTTGTAGCTGGCATTATTTTGTCA
+CTCTTCGGTGTCGGTAGTTACCATGGCGCGGGTGGCTTAAATCTAGGCAACCTTTTAGTC
+ATCTGTTTTGTGTTCGGTATGGTGGGCTCTTTAGTCTCTCTATTCATGTCCAAATGGATG
+GCTAAGAAAACTACTGGTACAGAACTGATTGACCCAAATGCTCCTCGTAACCAAGCTGAA
+AGCTGGTTATTGCAAACAGTCGCTGAACTTTCTCAACGTGCTGGTATTAATATGCCAGAA
+GTTGGTATCTTCCCTTCATATCAGTCTAATGCCTTTGCAACAGGCTGGAATAAAAATGAT
+GCCTTAGTTGCCGTTTCAAGTGGTCTACTTGAGCGTATGAACAAAGATGAGCTACGTGCT
+GTGCTCGCGCACGAGATCGGCCACGTTGCAAATGGTGATATGGTCACATTGGCACTCATC
+CAAGGTGTTGTAAACGCCTTCGTTATGTTCTTTGCTCGTGTAGTAGGTGACTTTATTGAC
+CGTAATGTCTTTGGTCGTCAAGACAATGAAGCCCCAGGTATGGGTTATTTCATCATTACA
+ATGGTTCTAGATATCGTGTTTGGTATTCTTGCCTCTGCCATTGTGATGTGGTTCTCTCGT
+TACCGTGAATACCGTGCAGATGAAGCCGGTGCGCGTTTAGCTGGTAAACAAGCGATGATT
+TCTGCTTTATTACGTTTGCAAGCTGAAACAGAGTTACCTGACCAAATGCCAAAAGAAATG
+AAAGCGTTCGCAATTGCGGAAGGTAAAGAACAAGGCTTTAGTTTAGCTGCATTGTTCCAA
+ACTCACCCTACAATTGAACAACGTGTGGCAGCTCTACACCAATTAGATTGTCCATAAAAC
+GTTTAATGTAAAAATAAAGCCTCCAAATGGAGGCTTTATTTTTTTGATTACATAGTTTGA
+TAAAGTCCCCAAAGGTAACTTGCACCCCACCACACAGCTAAGCCAATTAATAGCAGTACA
+AACGCACCTAATAAATCGGGTATGTGCAACCATAACCAACTCACAACAGGGTTACGCCAG
+AATGCCGACTGTTGTTGCTTCTTTTCGAGCTTTTCATGTAAATACGGATGAACGACATGA
+ATATCACTTTGGATCGCATATTCTTCACGTATATGCGTATGCACCACATCTAATGCTTTT
+CGACTGGGACGTATAAAAATATCGAAAATAGTCCCTGCAACCGGGACAAAACCGACTACA
+GCATCGACTACAGCAAGTTTGATCACTGGAGTGAGCTTATGCTGAGGCACACCTATTTGT
+TTAGCCTTATAAATGGCATAACACGTCAGTGCGAACCCAGCGACATCACCGGCAATTGGA
+ATAGTACTTAAGGCAGCATCAGCGCCAATACCCTGCTTTGTAAAAGGAATACGGACCGCA
+CTATCCATCATGGTTGCGAACTTGGCAAGATCTCGTTCTAGGGCGATAACCTGCTGCTGT
+GTTAATTTTTTTTCTTGAGGCATCAAAATCAAATATAAGAAGAAAAGTTAATCTTAATAT
+ACTTGATTTGATGCCCGTTTTTAAATTGTTTACTTTTAGGTTGAAGCTTTCGATTTAAAC
+AGTGAACGTAATAATACGTACATGACCGGAATAAAAAACAGAACCAGCACAGTACCAAAC
+ATCACGCCACCTAAAATACTAATACCAATCTCTTGACGACTAACCGCACCAGCACCTTGA
+GCAAACACAAGCGGAATTACGCCTGCCCCAAAGGCTAAAGAGGTCATTAGAATCGGTCTT
+AATCGTAAGCTCGCACCTTCTAAGGCCGCCTGAATGGCATTCTTACCTTTTTCTTGCGCT
+AAGGCCGCGAACTCAACAATTAAAATGGCGTTTTTACATGACAAACCAATAGTCGTTAAT
+AGCGCAATTTGGAAATACACGTCATTTGGCAAACCAAAAATATAAGAGAAAATCACACTT
+CCTCCTACACCAAGCGGAATAGATGTCATTACGGCGGCAGGAATACTTAAGCTTTCATAT
+AAAGCAGCTAAACATAAGAAAATAAATCCAGCCGAAATTAAATATAACCACACCGCCTGA
+TTAGTCGACTTCTGTTCTTCAAAAGATAAACCTGTCCACGCTAAACCAATATCTTTTTGT
+TGGTTAACAAGTTGTTCTACATCTTTCATCGCTTGGCCAGAACTGCTGCCACTCGCAACA
+TCTGCTTGTAGTTGTAAAGCACTATATCCCATATAGCGTTTTACAATTTCCGGTGCCCCG
+CCCCAGCTAAAGTTGGCAAATGAACTAAACGGAACCATTTCATTTTGGTCATTACGTACA
+GACCAGTTATATAAATCTTCCGGTTTAGATCTAAACTCGGCATCACCTTGAATCATGACA
+CGTTTAATACGGCCCCGATCAATAAAGTCATTTACATAAGTTCCGCCCCATGCGCTAGAT
+AAAGTATTATTAATTGCCGATAGCTGTAGTCCATTTGCTAGTGCCTGTTTCTGGTCAATC
+TTAATATTAAGATTTGCCTTACTATTGGTTGACTGCTTATCAAAGTTTTCGAAAGTTGAA
+TAATTTTTACTTTGAGCCTGCAATTGGCGGAAGGCACTATCTAGAAAATCTTGCCCTTGC
+CCATTCAAATCCTGAATCCATAAATCCAGACCATCTGTTTGACCTAAGCCATTAACTGAG
+GCAGGTAAAGTCACATTAATCTGTGCATTATTAAAATGACTAAAGTATTTCATTGCACGC
+TTTTGTATAGCCTCAGCCGAGTTTTCTTTTCCTGTTCGGACATCCCACGGTTTTAGAGCA
+ATAAACCCTTGTGCCAAGTTTTGTCCTGTGCCCGAATAATTTCGTCCATAGCGGATTAAA
+ACCAAATCTACGTTTTTATCTTCTTGAGTTAAGAAATATTGGCGGACTTGCTCACCAATT
+TTCTGACTTTGAGAAATTGGTGCGCTGTCTACGAGCTTAATTTGAACACTTAAAATCCCT
+TGGTCTTCTTTAGGAATAAAACCGCTTTTTAAACCGTTATAGAACAGCGTAAAAACGGCA
+ATTAAAGCCACAAAAATCACAATAACTGATTTACTGTAATGAATACTCGTCTGAACAAGC
+TTGATATATTGATTTTTAAGTTGCTCAATCTTTTGGTTAAACCATACGGCCCAGCGCTGA
+GGTTGAGGGTTTGGTTTTAAAATTAATGCACATAAAGCCGGTGTTAAAATGAGCGCAACA
+ATAAGGGACAACGCCATAGCGGCAACTAAAGTAATAGAAAACTGACGGTAAATCACCCCA
+ATTGAACCGCCTAAAAAGGACATTGGAATAAAAACAGCAGTTAAAACCAACGTAATTCCG
+ACTAAGGCACCACTAATTTCTCCCATCGACTCAATAGCAGCTTCTTTAGGAGATAAGTGC
+TGTTCATGCATGAGCCGCTCAACGTTTTCTACGACCACGATTGCATCATCGACCAACAAA
+CCAATCGCGAGTACCAGCGCAAATAACGTTAAGGTGTTAATACTAAAACCAAGCACATAT
+AAGACCGCGAAAGTTCCTAAAATTACAACTGGAACGGTAATACTCGGAATGAGCGTAGCA
+CGCCAGCTTTGTAAGAACAGGAACATGACCAAAATAACCAGAATAATCGCCTCTACCAGA
+GTCTTTACTACTTCCTTAATTGACTCTTGAACAAAGGGCGTATTATCTCGTGGATAAACG
+ATTTTATAACCCGCTGGTAGTTTCGTTGTAAGCTGATCTAGAGTTTGGTGGATGAGCTTA
+GAGGTCTGAATTGCATTTGCACCTGAAGATAAAGAAATACCCAAACCTGCGGCAGGATAG
+CCATTAATAGTGTTAAAAGACTGATAGTTTTCTGCACCTAGCTCAACTCTGGCAATATCT
+TTTAAATACACATAACTCGCCGTTTTATTCGACTTCACGACAATATTTTTAAAATCCTCA
+ACTGTTTTTAAGCGAGAACCTGCTGTGACTTTTGTATTTAAATATTGACCGTCAATTACG
+GGTAAGTCACCAATTGCCCCTGCGGCGACCTGAGTATTTTGTGCGGTGATTGCATTCGCT
+ACATCACTTGGCATTAAATTATATTGTTTTAATTTATCCGGATTTAACCAGATACGCATG
+GCATATTGTGAACCAAATACATCAGTTTCACCCACCCCTTCAATACGGTTCAGGTTATCT
+ACCACATGCGTAGTTAAATAGTCCGATAGCTCAATGTTTCCTGTTTTACCAGTCGAGTCA
+TATAAGCCAATTACCATAAAAGTGTCACCCAGTGACTTACTTACCGTAACACCTTGGCGT
+TGAACTTCATCCGGTAAGCGACGTATTACGCCACTAATACTATTTTGTACTTGGACCTGA
+GCAGTATCCGGATTTGTTCCGTTATCAAAACTTATAGTAATTCGACTACGTCCAGATGAG
+TCACTCGATGAACTAAAATAGAGTAAGTGGTCAATCCCTTGTATTTGCTGTTCTAAAATT
+TGAGTAACACTTTGCTCAACCGTTTGTGCATCTGCACCACTATAGTTGGCCGACACAGTA
+ATTTTAGGTGGAGCAATGTCTGGATACCGTTCTACAGGCAAATTCATAACCGAAAAAATA
+CCGAAAGCCATAACAATGATCGCCAATACATTGGCAAAAATGGGGCGTTGAATAAAGAAT
+TTAGATAGCATGGCTGCTCGGTATGATGTCGTTAATTAACAGAAGTAAATGCCGCTTCGA
+GACCTTGTGATGATCAACGAGCGGTATAAAAAAGACAAGTAGAATTAAACAATAAATGTA
+ATTAAGACAAAAACAAAGCGTGATTGAATATTTCCAACAAACCAATAAAAAACCAGTTAA
+CGAGTGTCACTTAAAATTCATGAATTCTTCATGATCATGTCAAACAAAGCACCGAAACTT
+GAGTCGTTTCAACTAAAACAATATGAGTAGAATTATGTTTAGAAAAGCACTTTTATGCTT
+AAGTTTAATTAGCTTGGTTGGTTGTAATGATGACGATAAAACTGAAACGACGCCAACCAC
+GCCAGAATATCAACTTCCTAAAATTCTAGTAGTAGGACACCGCGGCGCTAGCGCTTTACG
+TCCTGAACATACTTTAGCTTCATATCAAAAAGCGATTGATGACGGCGCAGATTTCATTGA
+ACCGGATCTAGTCTCTACAAAAGATGGCGTATTGGTTGCCCGCCATGAAAATGAGATTGG
+TGGAACAACCAATGTAAGCACTTTAAGTCAGTTTGCAGACCGTAAAAAAACAAAAAATAT
+TGATGGCGTCGACTTAACCGGTTGGTTCACGGAAGACTTCACTTTAAGTGAATTACAGCA
+GCTTAAAGCGCGTGAACGTATTCCTGAGTTTCGACCAGCCAACACAGCTTATAATGACCT
+TTACCCTGTCCCAACTCTAGAACAAATCATTGAGCTTGCCGAAGCTAACTATAAAAAGAC
+GGGGAAAATTATAGGTTTATATATTGAAACGAAACATCCGACTTATTTTAAAAATCAAAA
+TCTGGCAATGGAAGATACTCTTTTAAAAACCTTAGCCAAATATAAATATACACGTGATAT
+TGCACCTGTCTATTTACAGTCTTTTGAAGTGAGTAATTTAAAATATTTAAAAAATGAGCT
+TGATCTTCATAAGACGCTTAAACATGCACAAATTATTCAGCTATACGATTCAAAAACATC
+TCGACCAGCAGACTTCGTAGAGTCTGGTGACACTAAAACTTATGCTGATTTAGCCACAGC
+TCAAGGGTTAAAAGATGTTGCCAAATATGCAAATGGTGTAGGACCAAGTAAAGGTTACAT
+ACTGACCTTTAATAACGATGGCTCTTATAAAACTAGTACGTTTATTTCTGATGCACATAC
+GGCTGGCTTAAAAGTACATCCTTATACTTTCCGACCAGAAAATAACTTCTTACCAGCGCC
+GTTAAAGTGCAGCCCAGATAAACCTGCTGAACGTTGTCCATCTGGTGCGTTAAAAGAGTT
+TGAAGCCTATTTCAAGGCAGGTGTTGATGGCGTCTTTACAGATGACCCAGCACTCGGTCG
+TGAAGCTGTCACTAATTTTGAAAAAGCTGCAAAATAACTCAATCTTCATAAAAAAACAGG
+GCAATGAATGCCCTGTTTTTTTTATTTATCAAGACTGTTATTGAAATATAAAGGAATCCA
+CTGATACTGCTCAGCATTCACTTTATACACATGACCAATTCCCGGGAACGGTAAATGCGG
+GGCAGCTACCCATTGTTGCTTATTTGAAATTTCAGCAAACATTTTTAAACGAGTATTAAT
+TGCCTGCTCTGAATTTACATCAAAATCTACCCCAGTTTTTGGAGCATCAAACTGTAAAGA
+ATGTGAGTGGACAATATCACCAACAAAGACAATTTGTTGCCCTTTACTCTTCAAACGGAA
+GCTATGATGTCCCGGTGTGTGCCCTTGTGTATTGATTACTTCAAAACCTTGAATAACATC
+ATCATCTTTAAAGGTTTTGAATGCTTTTTTTGCTTGATAAGGTGCAAGTGCAGCTTTTAC
+GTTTTTAACAGTACCTAAATAATTTTCTTTTTTATCCGCTGGTACAGTTTTTTCATTTGC
+TGGATTTAACCAATAATCTGCTTCACGTTCATGAGCATAGATCGTTGCATTAGCAAATAC
+GGCTTTTCCATTTTGAGCAATACCGCACACATGGTCTGGATGTAAGTGGGTCAATAAAAC
+AGTTTTCACATTGGCAAGTTGATAGCCCGCTAATTCAAGATTTTTAGCAATTGAACCTAA
+CTGTGGACCAAAACAACTCGCAGCTCCACTGTCAACAAGCGTCAAACTTTTACCATCATC
+AACTAAAAAGGCATTTACTGAAGTCTGAATCCCCTTCTCATTTACAGCAGCATATTTCGT
+TAAAATTTTAGTTTTTTCAGCCGGACTTAAATTTTTAAACAATTTAGGATCTAGATAAAT
+AGTGCCATCGAGCAAGGAAGTTATCCGATAATTACCAAATTGATGATGGTAATATCCGGG
+TACTTGTTGAGCTGAAGCTGGTTCTGCATAGCTTATATGCAAGCTACCCATGATAAGTCC
+TAAGGCTACAAATAGTTTTTTCATCTCTTCTTCTCTATGGAGTTATAAAGTCAAAATCTT
+TAAAAAAGATTTAATATTTTTTTAAGGGCTGCACTATATAATGCATGAAAAGTGTCAAAA
+ATATAAGTGAATGGATAGTTATTCTCCCTATAAAGGTAAAAGTGGCCTAAAGCGCATCTT
+GAACGCTACCAGTTATTCAATTTCAGGATTTAAAGCTGCTTATCAAAATGAAGCTGCATT
+TCGGCAAATTGTTTTAATTAATCTTGTACTCATCCCTGTAAGCTTTTTCCTGGATGTAAC
+TCGCGGCGAACATGCCCTGATGATCATTGTCTGTTTATTTGCCATCATTGTTGAGCTCTT
+CAACTCTGCCATTGAAGCAGTGGTTGACCGAGTTTCACTCGAGAAACACCAACTTTCCAA
+AAATGCAAAAGATATGGGTAGTGCCGCTCAGTTTGTTGCACTTTCTATTATTGTCGCCAC
+TTGGCTTATTATTTTATTTGGATAAAAAAAACCATGCTTATAAATAGATAAGCATGGTTG
+TAACAAAAGAGGAACTTCTAGCTGCTGTTCCTGTTTTAATTTCAGGGTTCTGAACTTAAC
+TTATCCTTAAAATTACTGGAAAAATAAAAAAAATCCCTGCGAATGCAGGGATTTTTTTGG
+GTTAAAGCGTTGATGCGTTATTACATCATTCCGCCCATACCACCCATACCGCCCATATCT
+GGAGCAGCTGGTTTGTCTTCAGGAATGTCAGTAATCATACATTCTGTAGTTAACATTAAG
+CCAGCAACAGAAGCAGCGTGCTCAAGTGCAGAACGAGTTACTTTAGCTGGGTCAAGGATA
+CCCATTTCTAACATATCACCATATTCGCCAGTTGCAGCGTTGTAACCGAAGTTACCTTCA
+CCATTCTTAACAGCGTTGATAACTACAGATGGCTCATCACCAGCATTCGCAACGATTTGA
+CGAAGTGGAGCTTCGATCGCACGGCGTAAAATGTTGATACCAGCTGTTTGATCTTCGTTA
+GCGCCTTTTAAGCCTTCAAGAGCATTTACAGCGCGAACAAGAGCAACACCACCACCAGCA
+ACAACACCTTCTTCAACTGCTGCACGAGTTGCGTGAAGTGCGTCGTCTACGCGGTCTTTC
+TTCTCTTTCATTTCAACTTCAGTTGCTGCACCGATTTTAATTACAGCAACACCGCCTGCT
+AACTTAGCAACACGTTCTTGTAATTTTTCACGGTCATATTCTGAAGTAGACTCTTCGATT
+TGAGCACGGATTTGTTGAACACGCTCAGCGATAGCAGCAGCATCACCAGCACCGTCAACA
+ATAACTGTGTTTTCTTTAGAAACAGTGATTTTGTGCGCTGTACCTAAATCTTGAAGAGTT
+GCTTGTTCTAAAGACATACCAACTTCTTCAGAAATAACTGTTGCGCCAGTCAAGATCGCG
+ATATCTTGAAGCATTGCTTTACGACGGTCACCGAAACCAGGAGCTTTAACAGCACATACT
+TTGATGATACCGCGCATGTTGTTTACAACAAGAGTTGCAAGCGCTTCACCTTCAACATCT
+TCAGCGATGATAAGAAGTGGTTTACCAGTTTTAGCAACTGCTTCTAAAACAGAAATCAAT
+TCACGAATGTTGCTGATTTTTTTATCAACAAGAAGAATGAACGGATTTTCAAGTTCAGCA
+GTTAAAGTATCTTGTTTGTTTGCAAAGTACGGAGAGATATAACCACGGTCAAACTGCATA
+CCTTCTACAACGTCTAATGCGTCTTCGAAGCCAGAACCTTCTTCTACAGTGATTACGCCT
+TCTTTACCTACTTTTTCCATTGCTTGAGCAATAAGTTTACCAACAGTAGTATCAGAGTTA
+GCAGAGATTGAACCTACTTGTTCAATTGCTTTGAAATCATCAGCTGGTTTAGCAATAGAA
+CGGATATTTTCAACTACAGTTTTTACTGCAATGTCGATACCGCGTTTTAAATCCATTGGG
+TTCATACCAGCAGTTACTGATTTGATACCTTCATTTAAAATTGCTTGAGCAAGTACAGTT
+GCAGTTGTTGTACCGTCACCTGCGATGTCGTTAGTTTTGCTTGAAACTTCACGAACAAGT
+TGAGCACCCATGTTTTCAAACTTGTCTTTTAATGAAATTTCTTTTGCAACAGTTACACCG
+TCTTTAGTAATGTGCGGCGCACCGAAAGAGCGGTCGATCACAACATTACGGCCTTTAGGA
+CCTAAAGTCACTTTAACCGCATCTGCAAGTACGTTTACCCCTGCAATCATTTTTGAGCGA
+GCTGAATCACCAAATTTTACGTCTTTAGCTGACATATTAAACTCCGAATCTTTTTAAATA
+CTGAATCTGATAATGAATTGAGTTATGGATCGATTAGCCTTCTAATACAGCTAAGATGTC
+TGACTCTTTCATGATTAAGAGTTCTTCACCATTTACTTTAACTGTTGTACCTGCATAAGT
+ACCAAATAACACCTTGTCACCAACTTTAACATCCAAAGCACGTACGCCGTTATCAGTGAT
+TTGACCATTGCCTACTGCAATTACTTCACCTTGAGATGGTTTTTCAGCAGCAGAACCTGG
+CAATAAAATACCGCCAGCAGTTTTGGTTTCTTCTTCTACGCGACGAATCACAACGCGATC
+ATGTAATGGACGAATGTTGCTCATAATTAACTCCATCAGACTTAGTCTTTTTGATTAATC
+GTTATTGCTTTAATCCAGAGCAATAACAAAATATTTAGATGTCACTTTTGTGGGGATGAA
+AAAAATGGCTTCAAGGGGAAATAAGAAAAATTTTTCTCTTTTTTGAATATTTTTTAAACA
+ATCAATTATTTAAGCTCATCTAAACCAAATCAATATGAAGTGAATTCAGCCAGCTGTTCA
+TTAAACCAATAATGTCGAATTTTTCCTTCATTTGAAATTGTATTAAAGCTATTTGGATTA
+TGATGATATAAGCGAGTAGAAGTTGCTGTACCTGCATGTATATCAAAAATAGGATGATCT
+ATTTTTAAAGAATAAATCTGAGTTAAATCATATATAGCTGTTTTATGGAGATGCCCATGT
+AACATTCCAAATAGACCAGTTGTACTCCACTTTTCTAAAGCGATTTTGCCCAGAACCGGA
+CAATCTTTTATTCCATGCTTATTATCAGGCGGCGTATAAAAGGGTTGATGAAAAACAACC
+AGCTTTATTTTATTTTTAGGTCCCCTGTCTAAACGCTCATAAGTAGCTTGAATTTGTTCA
+ATCGAAATATGCCCACGCGTATGATAACGACGACGTATACTATTCACCCCAACAATATAA
+AAATGTTCAGTTTCTAAAGTCGGCTCTAATTCACCAAAAAAATATCTATAACGGGTAAAT
+GGAGAAAAAAAACGGTTCCAGACATGATACAAAGGTATATCGTGGTTACCAGGCACCACA
+AGATAAGGAATATTGAGGCTATCTAAATACTGTCGACATTTAAAAAATTGTTCATATTTG
+GCGCGTTGAGTAATATCGCCGCTCACAACAATCACTTCAGGCTGTTGCTGAATACAAAAA
+TCTCTTATTGCCTCTAAACACTCTTTTTTTTCTGTCCCAAAGTGTAAATCAGACAGATGT
+AGTAACATTCGGCACCATAATATTTAAAGCATTTTTTTCTACAGTGAAGTTTAAAGGAGG
+TTTCATCTCTATGATTTCTCCATCTAAGGCCACTGTGAGTTTGGTTTTCTTTGCACATTC
+AACAATGACATGATCAGCACAAAAACTATATACATCTTGTGCATCTTCAACTTTACCTTG
+AACCCATTGCCAAAGCATATTTAATAAACTCAGCTTATCACTTTTTGTAATTACAACTCC
+AGCGACTCTTCCCTGTGCTGCACATTCTGCAATTCTGAGCTTCATATCACATAGTTGCAA
+TTGGTTATTTCCAAAGAAAATAAGCGGCGCTTTAACTGGATATTTCTTGCCATCTACAGT
+TATAGAAAGCTTCATTGATTTATTTTCTCTCAATAAAACATCTAAAGCTGAGGTATAGGC
+ATGTAAAGGCAGTCTTCCTAAATATTTATTATAAAGCTCACGTTTCTTTATAAATAATGG
+ATAAAGTCCTAGACTCGCATTATTTAGATAAATATGATCATTAATAACTGCTACATGTAC
+TGACCTAGGTTTACCTGTTGCAATAACCTCTGCTGCCTCTAAAAGGTCTAACGGAATCTC
+TAAAACTTTAGCAACATAATTAAAAGTCCCTAAGGGCAGAATTCCCATGGGAATAGGAGT
+ATTTTTAAGTTTAGTTGCAACCGCATTTAAAGTACCATCTCCTCCTGCCGCAACAACCAC
+TCCTGTATTTTCATTTTGTGAATGTCGATGAATAACATTATTTATCAAATCATCAAATAA
+TGTATTTTCATTTAATTCAAATACTTGTATTTCAAAACCATATTCTGTAAATACAGTCAT
+GAGCTGCTCATAGACGTCTTCATGTTTTGAAGCATGAAATCCTGATTTTTCGTTATAGAT
+GATTGAAAGAGGTTTCAAAGGCCGCATTTTATTATCGTAAAGTCAGTTCTTTATTCTATT
+TTGTATATAAAATCGCCTATTAAAAGTCTCTTTATGTAAATTTTGAATGAGCTTCATTTG
+TATAATCAATAATAATTCTCAAAAAAATTTTTCAAGCCTAATTAATTGATTTTAAATAAA
+ATAATTTAGATAAATAACATACATATAACATAAAAATATAAAAGCAAAAACCTTATAAAA
+ACATATAAACATATGATTTTAATTAAAAAATAAAGAAAACTCCAAATATCTGCTAGTTAG
+TCTTTAGTCTTATTTTTTTTATGATTTTATGCTTTAATACAGCCACTTTTTTATTTGATC
+TTTCATTGTATCCCAATGAATGACTTGTACGTTGTACATATTTTGAATAGGCCTCACCAT
+GACCACAGTGAACGCACCAGAATTCGTTCGTCATCCTAAGCTTATAGCATGGGTTGAAGA
+AATTGCAAACTTAACCAAACCAGCAAAAATCGAATGGTGTGACGGAAGCGAAGAAGAGTA
+TCAACGTCTAATCGACTTGATGATCGCTAACGGCACCATGCAGAAATTAAACCAAGAAAA
+ACATCCTGGTTCTTATCTTGCAAATTCTGACCCATCTGACGTTGCGCGTGTTGAAGATCG
+TACTTACATCTGCTCTCAAAATAAAGAAGATGCTGGTGCGACAAACAACTGGGAAGATCC
+AGCTGTTATGCGTGAAAAATTAAATGGTTTATTTGAAGGTTCAATGAAAGGCCGTACCAT
+GTACGTTGTTCCTTTCTCTATGGGTCCTTTAGGTAGCCATATTGCTCACATTGGTATCGA
+GTTAACTGACTCTCCTTATGTAGCTGTTAGCATGCGCAAAATGGCACGTATGGGTAAAGC
+AGTTTATGATGTATTAGGTACAGATGGCGAGTTTGTTCCTTGTGTACATACAGTAGGTGC
+TCCACTTGCTGAAGGTCAAAAAGATGTTGCTTGGCCTTGTAACCCAGAGAAATATATCGT
+TCATTACCCAGAAACTCGCGAAATCTGGTCTTTCGGTTCTGGTTACGGCGGTAACGCGTT
+ACTTGGTAAAAAATGTTTAGCTCTTCGTATCGCTTCTGTCATGGGACGCGAACAAGGTTG
+GTTAGCTGAACACATGCTTATTCTTGGTGTAACTAACCCTCAAGGTGAAAAACACTACAT
+CGCTGCTGCATTCCCGTCTGCTTGTGGTAAAACAAACTTTGCAATGTTAATTCCACCAGC
+AGGTTATGAAGGTTGGAAAATCGAAACTGTAGGTGACGATATTGCTTGGATTAAACCAGG
+TGAAGATGGTCGCTTATATGCGATTAACCCTGAAGCTGGTTTCTTCGGTGTAGCACCTGG
+TACAAATACTAAAACTAACCCGAATTGTATGGCAACTCTTCACAAAGACGTTATCTATAC
+AAACGTAGCAGTAACTGACGATGGTCAAGTATGGTGGGAAGGTCTTTCTAAAGAAGTTCC
+AGCAAACTTAACTAACTGGAAAGGTCAACCTCACGTAAACGGCGAAAAAGCAGCACATCC
+AAATGCTCGTTTCACTGTTGCAGCAGGTCAATGTCCATCTATCGATGCTGATTGGGAAAA
+CCCAGCAGGTGTTCCAATTTCTGCATTCATCTTCGGTGGTCGTCGTGCAGATACAGTACC
+TTTAGTTTCTGAAGCTTTCGACTGGGTTGACGGTGTATATAAAGCGGCAACTATGGGTTC
+TGAAACTACTGCTGCTGCTGTTGGTCAACAAGGTATTGTTCGCCGTGACCCATTCGCGAT
+GCTTCCATTTGCTGGCTATAACATGGCTGACTACTTTGACCACTGGTTAAACCTTGGTGC
+GAAAGTAAGTGAAAAAGCTGAAGCTTCTGGCAACAAATTACCAAAAATCTTCAACGTAAA
+CTGGTTCCGTCGTGATGCGGAAGGCAACTTCGTATGGCCTGGTTTCGGTCAAAACATGCG
+TGTTCTTGAGTGGATCATTGATCGTTGTGAAGGTCGTGCGAACGCTGTTGAAACACCTAT
+CGGTTTTGTTCCAACATATGAAGACTTGAATTGGGAAGGCACTGAGTTCACTAAAGAACA
+ATTTGACCTCATCACAAATCAAGATAAAGACCAGTGGGTTACTGAAATTGAAAGCCACAC
+TGAGTTATTCAATAAACTTGGCGAACGCTTACCTAAAGCATTAAAAGAACGTCAAGCAGC
+TTTACTTGAAGCTGTAAAAACTGGCTTCTAATTACTCTATATAAAAAAGGTCGCCATGTG
+CGACCTTTTTTATTATGCGGCATCGTCTTTTAATCGACGTTCTGATGAATAGGCTTCTAA
+AACTTTTACCTGTTTTACATCAAATGCCAAACCTAATTTAGATCTGCGCCAAAGTATATC
+TTCTGCTGTGTGAGCCCATTCATATTCACACAAATATCTGACTTCACACTCAAACAAATC
+ATGGCCAAAATGTTGACCCAATTGTTCTATAGCATTTCGCTCTTTAAGCATATTCCACAC
+TCTTGTGCCATATGCATGAGCCCAACGGTTGGCAAGTGCGTCAGAAATTCTACTTACACG
+TGTTTTAATCTGATTGATTAAATCATCTAGTGTGGTCCAGTTTTCGGCGCCAGGTAATGC
+TTCATCTGCAGTCCACTCCTCTGCCATGTCATTAAAAAAAGGAGCCAGATGTTCTAAAGC
+AGCTTCGGCTAACTTTCGGTAAGTTGTAATCTTGCCCCCAAACACTGAGAGCAATGGTGT
+GGTTTTATCTTCTGCCTGTAGAGCCAAAGTATAGTCGCGTGTAATTGCAGATGGATTATC
+CGACTCATCATCACATAAAGCACGCACACCCGAGTACTGACTTACAATATCAGCTCGCGT
+CAACTGCTTTTTAAAATGTGAATTTGTCACTGTCAAAAGGTAATCAATTTCCACATCAGT
+AATCTCTACTTTTTGTGGGTCGCCTATGTATTCCTGATCTGTTGTACCAATGAGGGTATA
+TTTTTCTAAATAAGGAATTGCAAAAACGATCCGTCGATCTTCGTTTTGCATAATAAAGGC
+CTTATGGCAGTCATATAATTTTGGCACAACAATATGACTTCCTTGTATAAGCCTAATTTG
+ATAAGGCGAACTTAAACCCAGGTTTTTACTAATAATTTCTTCAACCCAAGACCCCGCCGC
+ATTTACAATAGCTTTCGCACGTATCTGATAGAACTCAGCTCCGCTTTGTAACTCCAGATG
+CCACAATTCCTGTTGTCTATAAGCCTTAACACAACGTGTACGTGTAACGACTTTTGCCCC
+TTTCTCTTTAGCTTGTAGTGCATTTAACACCACAAGACGCGCATCATCTACAGTACAGTC
+AGAATATTCAAAACCACGTGTTATCGCTGGTTTTAAAGGGCTGTCTTCTTTGAAATAAAT
+GAGATTTGATCCTAATAATTTTTCTCGTTTTCCCAAATAATCATAAAAAAATAGACCTGC
+TCGAATTAGCCATGCAGGGCGTAAATGGGATCGATGAGGCATGATAAAACGCATTGGTTT
+AATAATATGTGGCGCTTTAGCTAGCAATACTTCACGCTCTGCTAATGCTTCTCTGACCAG
+CCTGAATTCTTTATGTTCTAAATAACGTAGGCCGCCATGAATTAATTTGCTGCTAGCAGA
+TGAGGTATGACTGGCTAAATCATCTTTTTCACATAAAAATACCGATAATCCGCGCCCTGC
+TGCATCATTGGCAATACCAACACCATTAATACCGCCACCAATTACGGCAAAATCATATAT
+TTTTGAATAATCATTAGGTTGTACTTTCATTTCTCATGTTCTTTTTATTGTTGATCTTAT
+AAAAATTAAAACATCAAATTGATGAAACAACAATCAAAAAAGTAGAATAATCAATTTTAC
+ATCCTCTAGTATTTAACTATCCATTGACTACCCTACTATTGAATTCAACTAGTTAAGAAA
+AAGCTCAATCCTCTGCCCAATTTTGGCTACGCTTAACTGCTTTTAGCCAACCTTTATAAA
+TGAGTTCAGCTTGTTCAGAAGGCATTTTCGGTTCAAATACCTTTTCTATGGCAGATTTAT
+TTCTTAACTCATGAAGATCTTGCCAAAAACCAGTGGCCAACCCTGCCAGGAAAGCTGCAC
+CCAATGCTGTAGTTTCTTTCATTATTGGACGTTCTACCGGTGTCGTTAAAATATCGGCCT
+GAAATTGCATCAAGAAATTATTTTCCGTTACTCCTCCATCAACACGGAGTGTACGAAGCT
+CTTCTTCTGCATCTTGTTGCATGGCATCTAAAACATCTCGAGTTTGAAAGGCTATAGACT
+CTAGAGTTGCGCGGATAATATGTTCAATACTAGCCCCACGCGTCAGACCAAAAATTGCGC
+CGCGAGCTGTCGGGTCCCAATACGGTGCTCCTAACCCGGTAAAAGCAGGTACTACATATA
+CACCATTATTATCCTTTACACGTGTTGCATAAAGCTCGGAATCCTTAGCATTCTTAATAA
+CCTTTAATTCATCGCGTAACCACTGTACGCAAGAACCACCGTTAAATACGGCACCCTCTA
+AGGCATAGTTCACCTCACCACTCGCACCACAGGCAATAGTTGTGAGTAATCCATGCTCTG
+AACGGACAATCTTTTTACCCGTATTCATGAGTAGAAAACAGCCGGTACCGTAGGTATTTT
+TAGCCTGTCCCGACTCAACACACATTTGACCAAAAAGCGCAGCCTGCTGATCACCCGCGA
+TTCCGGCAATTGGGATCCCTACTTCTTGTCCACTAATGGTATGTGTATATCCATAAACCT
+CAGATGAACTACGAACCTCCGGCAACATTGCTCTAGGAATGTCTAAAGCTTGTAAAAGCT
+TTTCATCCCACTCAAGCTTTTCAGTATCAAACAGCATGGTTCGAGATGCATTGGTAAAAT
+CAGTGACATGGACGGCCCCATTAGTTAGTTTCCAAATGAGCCAAGTGTCCACCGTACCGA
+ATAATAACTCTCCCCGCTCAGCACGCTCACGGCTGCCTTCAACATGATCCAAAATCCATT
+TAATTTTTGTGGCCGAGAAATATGGATCAATGACTAAACCGGTGGTCTTACGGATATATT
+CTTGCCAACCTGCTTTATACAATTGATTGCATATTTCGGTTGTTTGTCGGCTTTGCCAAA
+CAATCGCATTGTAAATAGGTCTTCCTGTTTTTTTGTCCCAGACAATGGTGGTTTCCCGCT
+GGTTTGTAATTCCAATTGCCGCAACTTGTTCACTCTTGATGCCAGCTTGAGCCAATGCTT
+CGACCCATACAGCACTTTGAGTTGCCCAAATTTCCATAGGATCATGCTCAACCCAACCTG
+GCTGAGGGTAAATCTGGGTAAATTCTCTTTGAGCAATACTGACAACGTTCGCATCATGAT
+CTAAAACAATTGCTCTTGAGCTTGTTGTTCCCTGATCAAAAGCGACAATATATTTTTTCG
+GGCAATTTGACATCTGAATGTCCCTTTCATTTTCCACACACATCTAGCCCATAATGCAAA
+AACATCATGCCTAACTGTATTTATTTAAAATTTTCTTTGGAATATATCATTATTTTTAAG
+TGGCATAGGCTTTCTTCGTCCAAACATTACCCATTCTTTATCAATTTTTTACTGCATGGA
+AAAAAGTAATAAGAAAAATATTGAAATTAGAAGATAAAAATATGCTGATCGGCTAATTTG
+AAATCACATAAATATTCAACTTATTCCTTTGCTTAAATAATAAACATTGTTTTACAGACA
+TAAAAAAAATAAAGTGAAATACTCCTGTAGATAATATGTAAAAACGGAATAAATCTTCTC
+TTTTTTAGCATTCAACCCAAGCGAAACATGGAGCGAATCATGGTTGATCAACCTTCTACC
+GCAACAACTCCACATTCTAATTTAGATACAAAAACCCGTCTAAAATCAATTTTGGGCGGT
+TCTGCCGGTAACCTTGTCGAATGGTACGACTGGTATGTATATGCCGCATTTACGCTCTAT
+TTTGCTCATGCATTTTTCCCAAAAGGAAGTCAAACCGCTCAACTTCTTCAAGCTGCAGCT
+ATTTTTGCAGTGGGTTTCCTTATGCGTCCCATTGGCGCATGGATTATGGGGATCTATTCT
+GACCGTAAAGGACGTAAAGCGGGCCTTACACTTTCCGTTACTTTAATGTGTATCGGTTCG
+CTACTGATTGCTGTTACACCCTCCTACGAAAGTATTGGTGTATTTGCTCCATTGCTTTTG
+GTTATTGCACGTTTAATTCAAGGCTTAAGTGTAGGCGGTGAATATGGCGCAAGTGCAACG
+TATTTAAGTGAAATGGCAGAAAAAGATCGTCGTGGTTTTTTCTCAAGCTTTCAATATGTC
+ACTTTAATTGCAGGACAGCTTACAGCTTTATGCGTACTACTTATCTTGCAAATGATACTC
+ACCGAAGAACAACTGCATGACTGGGGATGGCGTGTTCCGTTTTTCATCGGAGCCCTTTTA
+GCTATCGTGGTGTTCCGTATTCGTCGTGGCTTATTGGAAACTCAATCCTTTAAAAACGCT
+CAAGCAGAAACAGATCAGCCGAAATCAGGAATGTTTGCTTTATTTAAACATTACCCTAAA
+GAAGCCTTCACTGTATTATTCCTAACTGCTGGTGGTACTTTAGCTTTTTATACTTACACC
+ACCTATTTACAGAAATATTTAGTGAATACTTCTGGTTTTACCAAGCCTGAGGCTACTCAA
+ATTACCACTTTAGCCTTATTCATCTTTATGTGCTTACAGCCATTGGCAGGTGCCTTATCA
+GATCGAATTGGCCGTAAACCGCTTATGATCGCCTTCGGGGTTACAGGTGTTTTATTCACT
+TATATTTTGTTTGATACACTTGCAAACACGCATAACTACTGGACTGCTTTCTGGCTATGT
+TTAGGTGGACTGGTTATGGTAACCGGCTACACATCAATTAATGCTGTAGTGAAAGCTGAA
+CTTTTCCCTGCACATATTCGAGCTTTAGGTGTCGCATTACCTTATGCAATTGCGAATACT
+TTATTTGGTGGTACAGCCGAGTTTTTTGCATTAAGTTTTAAAGAAGCCGGGCACGAATCT
+TGGTTCTTTATTTACGTCAGTATCATGATTTTCATTTCATTGCTGATTTATATCTTCATG
+AAAGACACCAAACATCATTCAAAAATTAAAGAACATTAAAATCCTTCAATTAGAGCTAAT
+ATCATAAGTGAATGTTAGCTCTAACTTAGTGAATAAGCTCCAACAACGTTTCTATTTTAT
+GAGATACTTCATATAAGAAAATAAGGACGATACTGATGAATAAAAGTATTCTATGTTTGG
+CATTAAGTAGTATGTTCATTTTAACTGCCTGTCAGACTACGCCTCGACAATATAATGGTT
+CAACTGGCTACCAGATTGAAAACCAAACAAAAACTTCAGCGACTTTAGCTTACACTTTAG
+CTGGTCGTAGTAACCAGCAACTTGATGAGCGTAAATTGCAACGCGCTTGTCAAAATGTGT
+TAGGTGCTCAGAAAGTTTATAAATTATCAATTTTAAGCATCAATGAAATTCCTAATCCAG
+CTAAAGATGAGCATTACGGAATTCAACTAGGTGAAACCCGCGCTTCTTTTGGCTTATCAA
+ATACACCTAGCTTAAATAATGGTGAAGATTATGCGACACGCCAAGCACTTGAAGCACGTC
+CAAGTACATTAAAAGTCGTTCGTTATACTTGTTCATAACATAAAAAAGACGCTGTTTTTA
+CAGCGTCTTATAAAAACTTACATTTCTAAATTCTTTCGCTTCATCCAGATCTGGCCAAGT
+TGTTGCACTTCTTTCTTCAATTTTTTCATATTTTGGATGACTAAAATTTTTAACACGGCT
+ATCTGCTACCCATACTTCTGGTGCAAATTTTAAAAATTCGTCTAAGAAAAAGCGATTACA
+TTGGTCATATAACACATCGGCAGCAAGTAAAACATCGACTTGTTCAGCCTTATATAAATC
+ATCCAAATATTCGAGTTCTACATCATTAAGTAAAGCATTTTCACGACAAGCATTTAAACT
+GACCTGATCAATATCACAGCAGATTACGCGTTTTGCTCCTGCCATTTTTGCAGCAATTGC
+CACTACACCAGAACCTGCTCCGAAATCTAACACCACTTTATCTTTAACATGGTGCGGCTC
+TGCAAGTATCCACTGAGCCATCGCCAAGCCTGATGCCCAACAGAAAATCCAATACGGCGT
+GTCATTCCAGATACGGCGAATAACTTCGTCATCCAACCGATCAGTTGGAAAAACAGGTGG
+AATCAACCATAAAGAAATTGGAGTTTCTGGCAACTGTTGTGCCATTAATTCACAATGAGG
+AATGACTTCATGTAAGGCTTGAAGTAAATGTTCAGGGGCTTTGGTCAATTGAAAGGTGCA
+GCTCATAAATAAGCTCAACAATTTATAATTACTATTTGATCATCTGCATCGCGAGCAAGA
+CTAAAACAGTAGCTTAAAGCATGATATTGGCTAGTTACTAAAAATACGTTAGTTCAATTC
+CACTGCTTTAATTAGTGCAACCGTTTTGGTCTTGCGTAGCATTCGCTACTCATCCCGAAA
+GAAAAGTAACATACGAGCTCCTAACATTTTCCTTAAACGGTAGGATGCTGCCGTGAATAA
+ATTAAATTAACCTAAAGCTTTTTCAGCAGCTTCTACAGTTTGACGAATCAAAGTTGTAAT
+GGTCATTGGACCAACGCCACCCGGTACTGGTGTATAAGCAGAAGCAATTTCTTCAATACC
+TTGTAATTGAATATCGCCTACACCACCGCCATCACGTGGATGGAAACCAGCGTCAACAAC
+AACTGCACCTTGTTTAATCCAATCTTTTTGAATAAGTTCAGCTTTACCTACAGCACCAAC
+AATAATGTCAGCTTGTTTCACAAGCTCAGGTAAGTTTTGTGTACGTGAATGACAAATCGT
+TACTGTCGCATTTGCTTGCAACAACATCATTGCCATTGGTTTACCTAAAATTGCTGAACG
+ACCAACTACAACCGCGTGTTTGCCAGCAATTTCGATATTGTTTTCTTTAAGAATCGTCAT
+AATGCCAGCAGGAGTCGCTGAACCATATGCAGCTTCACCCATTGCCATACGGCCAAAACC
+AAGGCAAGTTACGCCATCTACATCTTTTGCTAAAGAGATTGCATCAAAACATGCGCGCTC
+ATCAATTTGTGCAGGAACTGGATGCTGTAAAAGAATACCGTGAACATCTGGATTGGCATT
+AAGCTTTTCAATTTCAGCTAATAATTGTTCTGTTGTGGTTTCTTGTGGTAATTCGATTTT
+TAATGAATCCATACCTACTCGGCGGCAGGCATTCCCCTTCATACGTACATAAGTTGCAGA
+AGCACCATCATCCCCAACCAAAATAGTCGCTAAAATTGGGGTACGACCTGTTTTCGCTTT
+TAAAGCTTCAACACGTACCAACAAATTTTCTTCAATTTGCTTTGCTAATGCACGACCGTC
+TAAAACCAATGCCACAGCACATCTCCAAGGTAG
+>NODE_12_length_39995_cov_63.3136_ID_23
+TAAATTCTTTTACTATGTTCCTTAAGATTAATAATTGAATTTATAGTTAGGTGAATTTAT
+GAATTTTAATAATAATATATCCATTAAAAAATTAACATTACTTATTTTTGTAATTATGTA
+TATTATATTTTTTCTAATAACAAGTTTAAATTTATATTCGTACTCAAAATACGAATTTAA
+TAAAACAGAAAAACTTATAGAAAATTTCAATGTCAGTCTGAGTCAGCAAGTTGTAGAAAA
+ATTAAATAATATTTCTGATGTATCAAAATATCCATTACTTATTCCTGAAGTGAGAAACTT
+ATATTCTATACTTGCTGCTGATAAACCTTATGATATAAGTGAATATAATTATTTAAAGTA
+CATTTGTGATATGATGCTAATCCAAAACACCTCAATAAATGGTGCTTACATATATGATTT
+GAGCGGAAGAGGCGTATCAAGTACACGTAATAGTTCTAATGATAAACTTAAAAATCCAAA
+GTCAGAAAAATGGTTTATAGATTCCTTAAATTCTAATGAATTTACATCAATTTTTCCTAA
+TATAAATGCAAGCGATATATTTGAATTTACTTCGCAAGACTCTAAACAGTTAATAGCATT
+GGCTAGAAAAATAATAGATATTAAAACAAAGAAAGTAACTGGAGTATTATTAATTACTAT
+TCCAATTGATGAAATTCGCAATTTATTAGTAAAAGATCATCTTCCATTTAATAATCAGAT
+AGTTTCTATCTATGATATTAATGGAAATTTAATTCTAACCACAGGCGAGGAATCCAATGT
+ATTTATTCCTACTTATGACCAGTTACACAATGCAACCACTACTCCTAGCATACAGTATAT
+GGATAGTAATATTGAATATATAGTTTCCTACAATACTATACCTTCAACAAGCTGGATAAT
+TGTAAATTCAATTCCTAAGTCAAATGCATATCATATAGACAACTTATATATTTTTTCGTT
+TATTATTAACATAACTTTCTTCTTAATTTTATTTATTGTGCTATATATATTTTTTATAAA
+AAGAATATTTAATCCTTTAAAGTTTTTAATCAAGAATATGGAGAGCAATGTTGAAAATAA
+TTTAAATTATAAAGTATCTTATACTAAAAATGACGAAATTGGAATATTAATGAAATCCTA
+TAATGAAATGAAAAGCAGAATAAGCGATTTAATTAATATTAATTATAAGAGCCAAATTGA
+ACAGAAAGAACTAGAACTTAAGCAACTTCAAAATCAAATTAATCCTCATTTTATATATAA
+TACCTTAGAATCTATTCGCATGATGGCAGAAATAAATGACGATATAGAAACTTCAACCAT
+GTCTGAATATTTTGGCTCTATTACAAGGTACAGTATGAATAGAAAAATAAACACCGTCTT
+ATTAAAGGAAGAAATAAGCATTATTGAAAATTATATTTACCTTCAAAAGATTAGATTCGA
+TCAGCTATTCACAATTGAAAATTTGATTACCTCCGAAATTCTAGACTGCGAAATAATTAA
+AATGATAATTCAGCCATTAATTGAAAACTCTATCTATCATGGCTTAAGTGAATGTAGCGG
+TGATGGGAAAATAGTAATTAAAGGTGAACATATAACTGAAAATCTAGTACTAACCATTTC
+TGACAACGGTATAGGTATGGATCATGTAAAATTAAAAAAATTAAATGATTATATTAATGA
+TAAGAATAATGATTTTAGCGGTACCGCCTTAAGGAATATAAACAAAAGATTAAAGTTGAA
+TTATGGCAATGACTATGGATTAGAAATTCATAGTATTCTCGGAAAAGGAACAACTATGGT
+GCTAACTATTCCATACATTGTAAAGTGAAACTAAGTCCATGGAGCCCCCTATGGACTTAG
+CCTTATTTTTCTTATTTACTTATTCCCTATAAACATCTATATTCCTATTTCAGAGTTGAA
+AATTAAAACCTTTTATATCAATTTTACTATTTACATAACTACTCCTTTATTTCCAAAATA
+TCACTTTACCTCGTTTATTACAAACAATTGCGACATAAAATCTTCACGTTTTCTCGACCA
+ATATTCACTAGCTTTTTCTGTATAATCTTTTGATAATACTATTCCTAAATTCATAAGTTC
+ATCACCGTAGTAATTTCCTTCTCTACCTTCTATTGAATACAGTTTATCCGCGTCAAGTCC
+CTGTAATTTTATACGATTATATTTTTCATTTGGCCTGCATAAAGCTTGATAGTAGCCCAC
+AATGGCTTGTGACTTATCATCAGACACTACCATCCATGAAGTTTCATTGCTTTCAAAAGG
+ATTTAGCATTCTATAAAAATCACCTTTTTGAATCAACGATTTATTTTTCTTAAAGAATTT
+AACTTGTTCTTTGACTATTTCCTTTTCCTCATCACTCATAGTATTAACATTAAGCTCATA
+CCCAAAAGTTCCAAAATATGCTACATTGGCTCTTGTGTTAAGCGGAGTAAGTCTTCCTAC
+CTGATGATTTGGTACTGCTGATACATGACTTCCTATTGCGCTTAATGGATAAATCATTGA
+AGTACCATATTGTATCTTTAATCTTTCTACAGCATCAGTATCATCGCTTGCCCAAGTCTG
+TGGTGCATAGTATAGCATTCCAGGATCAAATCTAGCCCCGCCGCCTGCGCATGATTCAAT
+TAAAAGCTCTGGGTATTTAGTTATTATCTTTTCAGCCAACTTATATACTCCAAGAATATA
+TCTATGGAATACTTCACCTTGTCTATCTTCTTCCAGCGCTAATGAATACGGTTCTGTTAT
+ATATCTGTTCATATCCCACTTAATATAAGAAATTTTAGAATTTCCCATTATGTTATCCAT
+CAAACTAAATACATATTCAACAACTTCATCCCTTGAGAAATCTAGGATGAATTGGTTTCT
+TCCATGAGACATGTTTCTGTTAGGTGTTTGAATAGCCCATTCTGGATGTTCTTTAAATAA
+TTTAGTATCCTTACATACCATTTCTGGCTCAAACCACAATCCAAATTTAAGTCCTATCTC
+TTCTACTTTTTCAGATAAACCAGCTATTCCATTTGGAAGTTTCTCTTTGTTTTCGAACCA
+ATCTCCAAGAGAACTTGTATCATCATTTCTTTTTCCGAACCAACCATCATCAAGTACAAA
+CAGCTCTATTCCCAGGTCCTTTGCAGCCCTTACTATAGAAAGTATCTTTTCTTCATCAAA
+GTCAAAATATGTTGCTTCCCAATTGTTTACAAGAATAGGACGTTCTTTATCTCTCCATTT
+ACCTCTTGCAAGTCTTGTTCTATAAAGTTTGTGGTAAGTTTGACTCATTGCATTTAAACC
+ATCATTAGTGTAGACAATTACACATTCTGGCGTTTGAAATTCTTCTCTTGAATCAAGTTT
+CCATTTGAACTCATAAGGATTAATACCCATCATAACTCTTGATACTCCATACGAATCAAC
+TTCAACTTGTCCTAAGAAATTTCCACTGTATACTAAACTAAAGCCATACACTTCTCCTAC
+ATATTCAGTTGTATTTGGACGTTTTAATATCACAAATGGATTATGAACATGACTACTTGC
+ACCTCTTAAACTGTGAATAGATTGCACACCTTCTGTTAACTTTCTCTTTTTAAGATGACA
+CTCTCTAGCCCAAGCACCTGATGTATGAATCATTTCAAAATCTGAATCTGCTAAATCAAC
+GCTACAGCTCATAGCATTGTCTATATAAAATGCCTCTTCCCCTTCATTAGTTATTTTTGC
+ATTTCTGCATATTGCATCAAGACCTTCGTATATTGTATAACTTAGTATTAGTTTACTATT
+TAATATCTCATCAAATAATGCAATTTCTAATGTTTGAGCTTCTGAAGCTGCTTCAATATA
+AGTCGATGGTAATCCATTTAACTTATTCTTTCCTTCAAATATTTTATATCCAACATATTT
+ATAGTTACTAATTCTACTTCCATTTTTACTTATAATCGTATGAGCCGGATATCTGTAGTC
+TGTAATTCCGTAGCTTGGATATTCCTGCTTTATATGTTCTAATGACGAAGTATGATTTCC
+CTCAAACATATTGCATGAAGGTTTAAGTTCTCTTTCCATTATATGTTTAAATGACTCTCT
+ATGCCTTAATCGTTTACCATAATAAACATTTTCCATCTGTTCTATGCCATCGATTACTCT
+AATAATATAACTTATATTATTATTATAAAGATGAAACTCTCTAGTATTTTCATTAAATTT
+AATTCCCATCTTATCTTTCTCCTTCTTAAGTATTTACAAAATAATACTTTAGTGTTTAGT
+ACACTGTAGATAGTGCTAAAATTCACTTAAACAATCATTTGAAGTTGGTTTACTTTTTTA
+AATATTCTGAAGAATATATATAGTAATATTCTTCAGAATATTTGTTTTAATTTTAAACTA
+AATATTTTTTATATAAATAGTTTAATAGCAATTATTTATTAATTTATAATTACCACCTAA
+ACTACAGGATAACTTTTCAAAACTTTAAGCTTTCCTTTTATTTCATAATTTCCAAGTGCT
+GCAGGTATTAAATAGCTATCTCCCATTTTTATCTTTTCTAAATACCCATTTCCTTCTATT
+ATTCCTTCTCCATCCACACAAGTTAAGATGTCAAATTTATCTTCATCACTGCTATCTTGC
+AATGTTTCTTCTATAGTTAATTTTTCTATTCCAAAATATTCATTTTTGCATAGTAAACTC
+TTTTTATAACCATCAAATGCTATTTCTTCTCCTTTAAGATTTTCACATTGAAGTTCAAAG
+TTTGTCACGTCTAATGCTTTTTCTACATGTATTTCTCTTGGTCTACCGTAATCATATACT
+CTATAGGTTACATCACTATTTTGTTGTATTTCAGCTATTATAACACCTTCACATATAGCA
+TGAATAAGTCCACTATTTATTAAAAAGCAATCACCTTTTTTTACATCTATCTTATTTAAA
+TATTTTTCAACTTCTCCTGATTTTATTGCCGCTTCAAATTCTTCCTTTGTACATCCTTTA
+GTACCAACTATCAAACTAGCATCTGGTTTAGCATCTACAACATACCATGCTTCTGTCTTA
+CCATAATCACCTTCATATTTAGCTGCATATTCATCTCCAGGATGAACTTGTACTGAAAGT
+TTTTCTCTTGAATTAATTAATTTCACTAGTAAAGGTAACTTTTCTAGGCTTACCTTAGCA
+CCAACGATGCTAGTTCCGTATTCTTTTATCAGTTCATCAAATCTGATTCCCTTGAATTCA
+CCATTTGCTACAATTCCTGTTCCATTTGGATGACAAGCTATATCCCAGCTTTCTCCGATT
+TTTCCCTCTGGAAGGTTATCTCTAAAAGTTTCTAGGTCTCTTCCTCCCCATATTTTTTCG
+TAGTATAAATTTTCAAATCTTATTGGATACATACTTCCTCCTACTCCCTCACTCGATATA
+TAAAAAACATATCATATATTATTAAAAACCTCACTTTAAATATATATTCTTTTCGGCAAC
+TTGTCTATACTTTTGCAGTTAAAAGCATACTTTATTCATTTAAGATAAAATTTATTAACT
+TATATGTACTCACATAAACTTATGACTCTTCTCTCGAAACTCCATTCAATTAATACAGCG
+ACTCAGCACACTCTCTCTTAATTACATATTTAGTATTAAATTTCCACTAAGGCATTTATA
+TAAATCACTTTCAATATCCAAAATTTACATACTTCCTTAGACGAAAAAGATGCTGCGATA
+ATGTATAATATTACTGCAACACCTTTAATTTATTTATATATTAATTTATTTATATAACTG
+TTATAGCTTTAAATTCAAAATTGTCATATCTGTGTCTAGAAAACGAGTACTCGAACGCTC
+TTCCATTTTCTAAGTATACAACCTTTTCCACTTCTGCTATTGGATCTCCATCCATTAACA
+ATAAATATTCTTTATCAAATTCATCTGCTTTACTTACCCTAACCGTCGAATGAGCACTTT
+GAATCTTTAATCCTAGCTTTCTCTGTAAAAAATTATATATAGACCCATTAACATCTTCTT
+TTTTTATTCCCTCTGCAATTGATAACGGCATATAAGTTTTTTCTATTACAATAGGTGCCT
+CATCTACATACCTTACTCTATGTATGAAGTAGACAAAATCACCGTTATCTATCTTAAATG
+TACTTGCAATTTTCTCATCGGCATTAATAATCTTAAAATCTAAAACTTTGCTTGTGACCT
+CATGCCCTAAATTAGTATTAGTTAATCCCGAAAACTGTTTTTTTCGAATAATCTCTTGAA
+TCTCTCCTTCGGTTATGTCCTTTATAAAACTTCCCGATCCCCTTCTCTTTACAACCAATC
+CTTCTGCAACTAACAAATCTAGAGCTTTCTTCACTGTCATTCTACTAGCATTAAATCTTT
+CGCATAGTTCTTTTTCAAACGGTAATTGTTCATTAGGCTTGTACTTGCCACTCAATATAT
+ATTCTTTAATCTGGGATGCTATTTTCTGATACTTTATCATAACTATTCCTTTCATATCTA
+ATTCTTCTTATTATGCAGACTTATAATTTAATTTTTTAAATATTTAAATATCTCACATGC
+TCTTGACTTAAAGGGAATTATGTGGTGGTTTTCCATTGCATTTGTTATTATAACTTATTA
+TTCCTTATACAACTTTCTTTATCAGTAATTATTGACCATTTCACTAAAAACCCCCACCAT
+ATTCCATATATTTTTTATACAACCTGCACAAATATACTCTACCCTTAATATATAATATAT
+GTCTTTCATGCACTCCTGTCTATACTTTTATTTAGTACTTGTTTATCTCACCAATAAATA
+AAGAATAGGCTGATTAATACCAACCTATTCTTCGTCATTACTATTTTACTACTATATAAA
+TAAAAATTATTTAAAATTATAATATATCCCCCTATAAAAAGACTTTTATCAAATAATCTA
+TCTTATAGGGGATATTTTAATTGAGATTATAAGCTTTATTAATGATCTTGTTGAGCTGCT
+AATTCATCAGCATAAGCCATAGCATCTGCTTTCTTAAAAAATGGGAAGTAAATTACAGTA
+GAAACTATTAAGAATACAAATTGTGCTAAAGCGTAACTAGGTCCACCAAGAATAAATCCT
+GAAATTACAGTTGGAACTGTCCATGGTACTAATATTGCCCCCATTGGTGTTAGTAAGCCT
+GATGCAATCGCGAAGTAAAGTAATACTGCATTTATTACTGGACCAAGTATAAATGGTACA
+CCCATGATTGGATTCATTACTACTGGAATACCAAATAATATTGGTTCATTAATATTAAAT
+AAATTTGGAGTAAGCGCTAACTTACCTAATTGCTTAAATTGAGCCGATTTTGCAAGGAAT
+AGTAGTAGTAGTGTAAGTCCCAATGTTTGACCACTACCTGTTAAATTAACAAAACTATCA
+TAGAATTGTTGAGTCACTATATGAGCACCATGAGCAAGGTCTAAAGTCCCCGCTTTTTGT
+AATTCTGCATTGAATGCAGTATTAGCAGTTAATAATGGGCCTACCATTCCTCCTACTGTA
+ATACCTCCATGAATTCCAAAAAACCATAAGAATGGAACAGCAAATGCAATAAGCATAGCT
+CCAGGTAATGAATCTGATGCTGCTTGTAATGGTGTTTGAACCACTTTATAAATAATCTCT
+ACAAAAGAAGTTTGGAATCCAAATTTGCATAATGCATAAACAACAGCAGCTCCACTAAAT
+ATAACAGTAGCCGGAATTAAAGCTGAGAATGCATTAACAACACCTTGTGGAACACCCTCT
+GGCATTTTTATTGTAATGTTTCGCTTAATCATTGCGCAATAAACAAATGAAACAATCAAA
+CTAACTACAATTGCAGTAATCATACCTGCTCCACCGGTCCAAGATGTAGGAATAGCACCG
+CCCACTTGAACTGGAGTCGCGTCTGGTGTCGGCTGATAAGTAACAAAGTTATTAGTAACT
+ATAACAAATACACTTAGAGCAATTACTGATGGTGAAAACGGCTCTACTCCCTCATTCTTG
+CAGTATGAGTAAGTCATTCCTATAACTCCAACCAATGCCATAATGCCCATTGTTGATCCT
+TGTACTTTGTATAATGGATCATTCCAACCTGCACCAAAAGTTGAAGTCATAAAATCTGTA
+AATGCTTTTAATGGAAAAGCTGCAATTAATAAAAATACAGATCCAATAATATTCAATGGT
+AATGTAAACATCATACCATCTTTTAACGCTTGGACACCTTTAAGATTAACGAATTTCATA
+ATTACTGGAACTATTTTTTCGTTAAGTGTTTGATTAAATGACATAATTATTCCTCCTTTG
+AATTAAAAATATAATATAAATAATTACAAATATAAATTTGCTATTATTGCCTTATTGAAT
+TTTTATTACTTTAAATGTTTTTAAACTTAATATTATCTAAGTACTATAGCGTCTAGATTC
+AATATATATGCTTAAAGTACTATTTCTTAATTAAACTTAATGCTAAATCTAATACTTTAG
+CTCCATTCATCATTCCATAATCAACCATAGGTATCACTTCTACTGGAACTCCTTTTGGTT
+CACAAAGACTTTTTGCTTTTCCTAAAGTATATCCAACTTGTGGTCCTAAAAGTGCAACAT
+CCATGCTATCTAGATGTCTATCCATTTGTGATTCTGGGAATGCTATAATTTCTGCATCTA
+TCCCCTTAGCCTTAGCTGCTTCCTTCATCTTATTAACTAAAACACTTGTTGACATCCCTG
+ATGCGCAGAATAATTTAATTGTAATCATAATTGTTCCTCCTTAAAATCTTTCTATAAATA
+AAATAATGTATTAAATACTTAAGTACGTTTACATCAACGCACTAGTAATATGTTGATAAG
+CAAATAATATATTTATTTATTAAGTAAAGTATTTACAACTTTTCTTAATTCTATAATTTG
+TTCTATTAAAGTTTTCTCAGATATAGCTGTCATTAAATGATCTTGTGCATGAACAAACAA
+AACTGATAATTCTATTTTTTCACCTGCGGCTTCTTTCTGAAGCATTTCTGTTTGTGCATC
+GTGTGCCTTAGCTAAAGCATCATTAGCCAAACCCATCTCTTTTTCAGCTTCTTCATACTT
+ACCTTCATTTGCCATTCCTAGCGCCATATAAGCATGATTTTTACAATCTCCTGCATTAAT
+TATAATATTCATTATTGCCATTTCTAGTTGATCCATTTTTACTCCTCCAATTTGCGTGTT
+ATTTTTTATGCAATTATATAGAGCAATAAATATGCCAAACACTATTAATGATATAAGTTT
+TTATAATTTTCATCCCCAAACTTATATATATTTATAAAACAAAATGAATGAATATTATAT
+ATTATAAGTATATACATTTATTTTAAAAAGATTATATATTTTATTTTCCAAGCACACAAT
+ATTTATCAATATATGTAGTGTTTAAGCAAAGCATACAGTGTTTATATAAATATTTATAGT
+GTTTGAAAAAATAATATCTGGTGTTTCATTTTTTCAAACACTGAACCTTTTATTATAAAA
+CAATATTCGATACTAAACCCTTTATCCATTATCATATATGCATCTATTACTGCTGACTTA
+TTTTTCACTAGCCAACAATCTTCTGATATAGTCTCGTAAATCAATTTACAGAATCGAAAA
+TTAACATATAAAAAGAGAAAGTCAAATGATTCCTTCATCTAAACTTTCTCTTAAAAACAT
+GTTCTAAACTCGCTACTTTAATTTTTATATTTCATTATACCCAAGCACCACTTGCATCTA
+CTGTATAACCGTCAATAACTGTATCACTAGCCATAAATCCATCACTATATAAATAGTACC
+ATTTATCATCTACTTTCTGCCAACCTATTTGCATTTGGCCAAATGAAGCCAATAAGTACC
+ACTTACCATTTACTAGCTGCCAGCCTGTTTGCATTGCACCAGTTTTAGCTAGCAAATACC
+AATTCCCCTTTACTTGTTGCCAGCCCGTTTGCGCTGTACCAGTTTCATTAGCTAAATACC
+AAGTACCATTTATTTGTTGCCAACCCGTTTTAGGTTGTCCATTGCTATCGAGCAATTTTA
+CAGTCCCATCAGCACTTGTGTTTAAAATTGCTGTAGTTACACCTGTTGTAACTGAATTTT
+CAGTTGTTGTGCTCGTTGTTGTAGTTGACCCACTGTTCGATGAACTACTATTTGATGATG
+TACTTGAACTACTACTTGATGAATTTCTCGCAATAGAAGACGTAGTACTTTCAAATATCT
+TACCATTATAAGTAACTAATAATTTAATATAATATCCTTTATCACTGCCAATTAACCTAT
+AAGTTTTATCAGTTCCCACTAATGCACCGTTAGTGATACTATCATCTTTATTAAATAACC
+TATACCAAGCATATGTTACACCTTGAGATGGAACAAACTCTGTAGAATCTGCCTTTAATA
+ATTCAGCAGTTAGAGTTCCACCAACCCTTTCAGTTCCATTAATTGCAACTCTTGAAGGCA
+TTACTACTTCAGCTGTTCCACCTGTTGATCCTCCTGCATTTGTATTTCCTCCTGTTTGTT
+CTCCACCAGTATTATTGCTACCTGAATTTGAAGAACTTACCCCTTTAATATCATCAAAAT
+ACATTACTGAGTTAACAGTATCTGTTCCAATTGTATTGCACCATATTCCCATCTTCTCTA
+TATGAGCTTGGTCAAATGTTCCATTGTTTTTTCCTTTAAATTGGCTAAAAGGTATAGTTA
+GAAGTTTAGCTTCAGTTGTTGCTGCAAAATCCGGCATCCAAACTTCAAAATCTTCACCGT
+TTGATGTAAGTTGTATAACGAGTTTTTGACCTTTGCCATCTGGCTTAACCCAAATTTGTA
+ATGCATCGCAACCAGACCAATCCGCATCTAATGATTGTGTAATACCAGTCCATCCGTTTG
+GAGCAATCTTATAATTAAACGCAAGTCCATAATCGCCACTATTTTTATTATTTGTATCTA
+ACTTTGGTGTAACACTGCAGCCTGATCCAACATTAGTAGACCAAACGCCTTGAAGCAATG
+CATCTTCTCCTGAATATGATTCAAAATTATCTACCAATTTAGGATCTTTCTCTGCCTCTT
+TTATATTAAATATAGCTTTTATTGTATCTAATTTATTATCATCTGAATATAAATCAATAG
+ACCCAACAGCTTGTCCTATTTTATCGAGAATAGTTTGTGAAATTGCAGCTGAATATATAC
+CATTTTCATCTTTTGTAGCGTTAAGAGTTTCAATAGCATCTCCTGCTTTATTTTTCAATA
+CAAACTTAACTTGTCCATCATATTCTTTTACGCTTGCTGTTACTATAGTTGGTTCAAGAA
+TACGGCTGCTTGAAACTGGTCCTGTTATGAATCCATAAGAATATGCTGACTCTTTAGTTA
+TTGCAGAACTAGAGTAATCTTCCACTCCATCAGCAAATATTGATTTATCTTCATTATAGT
+AATTTATAAAGTTATTAATCATTTCATGACCTTTTGTATCACTTACCATATATGGAGCAA
+AGAAACCATCCGTTTCACCAAAATTCGCCCAAGTCATATAGTACGGCATATCCGAACTTG
+ATATTATATCAGCTACATGCTTAAACCAATCTTTATCGGCATTTCCTGATAGAGCCATAA
+AACCATTATTTTCATTGTTACGCAATCCTACTTCAGATACTGCTGAGAGTTTACCTTTAT
+TCTTTGCTATATTTTGAACTAGGCTAATAGTGTCTTTGAAACTCGCCATCCATGGATCTG
+TAGATGCATCTTCAGTAGGATTATCATCATAATAATCAAAAGCCAAGATATCAACAAATT
+CATCACCTGGATAACGTGATAAGTAATCTTCCTCATTTTCAAACGGCCCATTTGGTGAAT
+ATACATATAAGAAATTATGAACTTTATCAGTATCCCTTAAATATTCAACTGTATAACGAT
+ACATATTCTTGTACGCTTCCTCGTCACAATATGCTTTACCCCACCAGAACCAGCTTCCAT
+TATTCTCATGGAATGGCCTGAATATCACCGGAACTCCAGCATTCTCTAGTTTATGTGCAT
+AAGTTGCAAGCATATCTAAATACCCAACATATACATCATTCAAATCTCCACCTGGCATAA
+TCCTTGACACTATATTACCAGTTGTTGTTCCTGGAGTATATCCTGAATAATCATAATTTC
+CGTTTTTATCTTTTCCTTTTTCTTTAACTAATTCAAAATTTGGCATATGAGCTGACAAAG
+TTATTATACCGCCTTCATTTGACGCCTCTATGCTTAAATCTGCTGCTTTTGAAATCAAAT
+CCTTTCCAGCAGCTTTCTCTTCATCAGTTAATGATAATTCGGATCCCGTTAATGACAGGG
+CATCAATTCCAACAATCGCAGAAATAGAACTTGTTATATCCTTTGTGTCTGAATTAGTTG
+GACCATTTCCAGCCTTATGATGTGTATCATTTTGATGTCCATATAAAACATAATCCGATT
+TACCTACACCAGTTAAATATGAGTATAAATTTGCTGTTTTTGATGTTGCACTCGAGTCAA
+CTAACTTTACTTTTGAAGGCATTAAATCGCTTACATCAATTATATTTTGTGTTGTAGTAG
+TTGTTGTCTTTTCAACATATTTATCTGCTACTTGTTCTTGACTAAGTTTAATATTATCTA
+TATATATATCACCATTATAGTTAGTGCTTGCTCCTATAATTCCAATAGTAATTGAACTGG
+CATCTACATCCTTAGAAGTAAACTTAAGAGTTACCTGTACTTTCTTTAATCCAGTATTAC
+CAACATCTACCGAATTATTTAAGTCAATTGAGCCATAGGTATTTAAGCTATCTGTAATGA
+ATAATTTTGTTTGAAATCCTCCAGTAGTCATCTTACTTGGGTTATAAATAAAATCATATG
+TTAATATATTATATCCTTTAAATGAAGTTGCTGCACCCAAATCTTTGTTAATTTTAAATT
+CACTCCAGCCACTTGCAGAATCCTTAGAATAATCAAGGGAAAGCTTCAAAGCCCCACTGC
+CAATCGTAGTGTTATCATAATTTACAACGTTATCAGAAGATCCATGATAATCATAGGCTC
+CTCCATAAAACCATCCATCACTATCATTCTCAGAATTATCAAAATTCCATTTTAAATCAG
+AAACACTCGGAAGTGGTGCCGTATCACCTGAAGCTTGGTTGTTTACAATTTTAATGTTAT
+CTATAAATAGCTTACCATTGTAATTGCATTGATTTCCTACAATTTTAATATAGAAATTCG
+ATAATCCCACAGTATCTTTGTCAGTTTTTATAGATACAGTTTTTCTTATATAACCATTAA
+CAGCGCTTTCATTTTTGAAACCAGTTGAATCTACCGATCCCGAACCAATACCTGCATCCT
+TCCAATTGGAGTCTTGCAATGTGCTTTCCAAGTGAATCTCGCCAGTAAAATTAGCATTTG
+TTTGTGGAATTATAATATCAAATTGAATCTCAGAACCTGCTTTAATTTTTTCTGAGCTTT
+TAGCAATAAAATCAAGACAAGTTTCAGAATTCCATGTACTTACTCCGTCATAATTTGCAT
+TAAATCCTAACGCATTATTTCCATTTATATCTTCTATTGCTACACTTGATATATCTGCCT
+TCCAATTAACTTGATCCGGCAACTTCCCATCTTCAAAACCATTATAATAAACAGCAGAAG
+GGGTTGTACTAATTTCAGACAGCGCTGCGACTGTGTTAGTCTCATTAGTAGCTGCGGTAA
+CTGCTGCACTACTTGTACTGCTATTTAAATTTGTTGCATCGTTACTCCCCCCCTCCATAG
+TAACTGTTGTACTAGAGATGCCTGTACTATTTTCTAAAACTGTTGCATTATTATTTTCCG
+CTATTCCTATTGCTGAAACCGGTAAGATAGTAGTTGAAGTTGAGATTACCATAACTGTCG
+CTAATAGTTTTTTAATTTTTTTTGTTTTCATTAATTTTCCTCCTAATACCAAGTTATCGT
+TTAATTAACATTGCAAACTTTTAAAATTCACTTTTCTGATTTAGAGAATTCTTATTAGTT
+ATTTATTTATTTTTTAATTGTAAATCTTTGGTTAAACTTTATCAGTTAAAGCATAATTGA
+TACTATTACTTATTTGATTAATTTGCCTTGTTTATATTTTACTTTAACGATTAATTAAAG
+CATTTACATTATATAATAATTTAATAAGCTTTTCAATATATGGAAAAATGTTTTTATATA
+TGAAAAAAAACTCTTTATTATACATAAAACTTATCTTGTTAAAAATTCATTACCAGCAAG
+ACAAGCTTTTTCCATAACACATAATTGTTTAATAGTAATAAGAAAATATCTTTCTCTTAA
+CTACTTAAAATGAATTCTTTCTAAAGAAATAACCATGAATAATCAAAAAATTATATTTCT
+AACTATCCATGGTCCTCATTTATAATAATTTTTAATTGAAATATTTTAGAAAGCTATTTG
+CATTACTCACCTTATTTAGATAATATTCCCCTTAAATATTGAGTCAACTCTTTCGCTGCT
+TTCTGATGCGATAGAAATCCAGGATGTTGTCTTGATCCTACTGTTTCTTCTGTTGTATTT
+GGAAGCTGGAATACAGAAACCTTTTTATCACCAGTCTCTTTAATATATGCATCCACAGCA
+CGATAAATAGACGGAAGCATTGGAATTCCTAACATCCCATATACCCATACTATATTAGCC
+TTTTTATTATATTTTCTAAGTTTAACTAGAAAGTTATAAGCCGCTTTTTCAAAAGCTTCT
+AAATCTTCCTCATTAAATGTGCCATCCTCATTTAATCTTTGTTTATGAGTCTCTCCTGTA
+ACTTCATCTCTCCACTCAGGTGAAGTAAAAGCTCCTTCATCATTTGTTCCAAGGTTAACT
+ACTACAACATCTGGCTGCCAAGATTCAAAGTGGTTATCTTCGAAAGCTCCTAGAGATTCA
+TTTTTATCACCAGTAAGAAGTCCGCACACCTTTTCATAATACTCTGGAATATTATAATGA
+GGATTATTATCCCAACTTGTAAGTATCCCCCATCCACTTTGAGAAATAATTCTATGTTCT
+GCATTTAAGGCTTCTGCAGTCATTGTGCTATAATTATCTATCGCACTAAACCACATAGAA
+ATCCAATCTTCTTCTTTCTTAGCCCCTATTACTCCTTCTCCTGATGTAATACTATCTCCA
+ATAAATTCAATCTTGTACGTTTTTTCTTCTATAGGTAGACATTCCCCATCAAATTTCACA
+GCATGTATTTGCATATAACTTCCTGGGTCGCCATTCATAGCCTGAACATCTCTTATAATT
+TTAACATTTTTTATTTCATGCTCTGTCATCCCTCTAAATATACAAACCCAGTACCTTCCG
+GCAATTAACATTTGTCTGCTTACAGTAGCGGAATTAACAACTATACTAATCCAAGGCTCA
+TACATATCATAGTCCACTTCTACTTCAACCCAAAGTTCAGAGCCTTTCGCATTTAGCTCA
+ATACCACTTCCTGTCCAAAATACTGTTAGTGGTGAAAGACATCCAGTCGTTCTCCCATGA
+ACTTTTAAATTTTCAATATCTGATAATGGGTATATTTTTAGTTTTTCATTTTCTCTCATT
+ATTTTCCCTCCCACAAGTTTTCAATATTCAAACTATATTTTTATTTAATCCTCATTCTAA
+TTTAAATTATATTTATTTTTTACTCACTCTCCCTGGCTACTAATCACTTTTTGTTTCTAG
+TAGGCCCTCTTCATTACTTTTATATTACATCTGTAATTTCTTTAATTTATAGAACTCACC
+TTTTTTCTCCATCAGTTCATCATAAGTCCCAAACTCTTCTAATCCACCATTTCCTACAAC
+TGCAATCTTATCTGCATTTCTAATTGTAGATAGCCTATGTGCAACTACTAAGGTTGTTCT
+ATCTTTCACTAAGCTTTCAATTGATTCTTGTATCTTTTTTTCCGAAACGCTATCTAAAGC
+AGATGTTGCTTCATCAAGAACCAATATCTTCGGATTTCTCACAAAAGCTCTTGCAATTGA
+TATTCTCTGACGTTGTCCACCAGAGAGATTACTTCCATGTTCAGTAATTATGGTATCTAA
+TCCATTTGGGAGTGATTCTATTAACTCCTCCAAATTTGCCGCTTTAATTATTTTACTTAA
+CTCTTCATCAGAAATGTTTTTTATTCCATAAAGGATATTTTCCCGAATAGTATCAGAAAA
+TAATATTGCATTTTGTGGTACAACCGCAATCTTGGAACGATAGCTTTGAAGATTAATATT
+TTTAATATCCTGATTATCAATCAGTACTTGTCCGTCTGTGGCTTGGAAAAATCCTATTAC
+TAGATTTAGAATTGTCGATTTCCCGGCTCCTGAAGTGCCTACAAACGCTACTGTTTCTCC
+TGGATTTATAGAGAAATTTAGATTTTTTAAAATTGGACCAGTACTATCTTTGTACTGAAA
+TTCCACATCCTTAAATGTAATTTTCCCTTCTACATCCTTAATTTTCTTTTTCTTACGGTT
+ATTTTCTACATCGTCAGAAAGTAATATATCTCCAATCGAATCCACAGATTCCAGTCCTTT
+TGCAATAGTCGGCAATAGTGTAATAATACCCGAAATCTGTGCTACTATAGACCCAAAATA
+AGTTTGATATAATACAACTTCACCAATTGTAATGTTTCCTTTTAATGCTATATAACCTGT
+AAAACCAAGACAAATTATTTGGAACACTTGAAACGAAACCCAGCTTATGGATGAGAAATA
+TGCCTGAATAAGATCTAACTTCAAACCCTTTTTAGCAACATTCACCAACTGACTATCTAT
+TTTCTTTGTTTCTTGCTTTTCTAACGCATGAGCTCTGGTAACAGGAATTAATTCCACCAT
+TTCCATTACACGAACTGAAGTCTCTTCCATCTCTTTCCTATAGTCTGTATTATACCTTTT
+TATCTTTCCTCCAAAAGCAACTATAATAAGTACTGCTACAGGTATAGTTGCAAGAAAAAA
+CACAAACACTGTTAAACTCTTAAAAATAACAACTCCTAAAGCTGCTACAATATTTAATAC
+AATACCTAATATTGTTATAAAAACTTGAGATGATAGATTCTCAATCTGTTCAACATCACG
+CATAATCTTTGACTGTAATCTTCCTGATTGCATTTGATTATGATATGCAATAGAAAGCTG
+CTGAAGTCTTTTTACAAGAGTACTTCTGAGTTCTCTTTCTACACTTCTAATAGTTTTTGC
+ATATAGAACTGTATGTACATAATTTGTTGGTATATTTTGCAGTACCATAACAAGAATTAT
+TATAATATTAATTACAATAATATGAACTGCATTATCACCTTTATCGGTTGCTGCATTGAT
+AATATTCGCGGATACAACTGGCAGAACCCATACAGGAGAACTTTTTAATAGGAAAAATAT
+AATTGAAAGAAATAACTTTAAGTAATGTCCTTTATATATACCAACAAGAGTTTTTAAAGT
+ACTATTTTCATTCTGTTTAAAAATTTTCAAAAGAGCTTCTTCGCCTGGTTCTAACTTGTC
+ATTTGTTTTATCTTCTTCACCTATCACTTTTCCACCACCATATCATAATACTTCTTTATA
+ACTTTTTCTGCTGGTTTTCCATATACATCATAACCTTTATAATTTTCAGCTCTATTTAGA
+GAATATTGATTGCACGCCCAATCCCACATAGCAAAACCAGATACCCATTCACGTTTAAGC
+GAAGATTCAAACATAGCCTTGTACCATTCTGCTTGTTCATTTAAATCTATATCACCTTCA
+AGGCTCCAATCGTTTGGAACTTCTGAAGAACCTTTAGTGGACATACAACCAGCTTCAGCA
+AAGAAAAATGGCTTATCGAAATTTTTGACTACTTTTTCGATTCGATCTAACTCTTTTTCC
+CAATCCTTAAGTGGATAATAACCACTTGAAGATATAACATCAACACAATCCCACCATTTT
+ACATTATGCTCTTGATATTTATCAGTATTATAAGATACAGCTCCATGATAAACATCTCTA
+ATATCAGCAATTAGTTTACGCCATTCATTTTCTCTACGCTCCGACATAACCATTTCACAG
+CCTGCAATAAACATTTCACAACCTGTTTTTTCTGCTATACGAGCATAATGAAGTTGGAAA
+TCCGTGTAAGAAGCAAACCATTCACTCCATTTTGGCTCACAATGAACGTCTTCATCAAAG
+AAATTTATATGAGCCCTCCAAGTTCCATTTTTACAATTTACAGTCGGCTTAATCGCTATT
+CTAAGACCAATATGCTTTGCATAATTTATGATATTTTCTAACTCTGTATCTGAAATAGTA
+GAATTAGAACTATAACAAATCTCTTCTGATTGAGGAGTATCCTGAAGACCATTTGGTACC
+AATATTATAAAATTAATTCCAACCCTTTCTCTTAAATTATCTAAACTCTTATATGTTTCT
+TTTTTTAAATAGCTCCCTTTCCTCGCAAAAGGCGCAAAAGTAAACCCTTTAATAAATTTC
+ATAAATCCCATTCCTTTCTTTAAATTAAGCGCCATGAAGAAAATAACAGATCAAAATGTA
+ATGTATATTTTCTCAAAACAAATCAACTCTTTTGCTGTCATTTAACAAAAGATTTATAAA
+ACAAAAGTTCTAATTCTTGTACGAAGGTTTTATATACGCTAGGCAGAATAAGGCAAATCT
+TGTTTGTAGCAGATTTTATATAAAAAATAACCGACGTAATATGATATTAAATAAACAAAA
+ACATGCTGATCTATTATTTTTTTCATTGCGCCTCCGCTTACATATACTATATCAATTTCA
+TTTTTCATCTGATATAATACAATTGTTTAAAAATAGAACAAATCTATTTTACGGAGGCTA
+TTATGAATTATTTATTTGAAGAAATTAATGTTTTAACCTCACCCTATGAAGCCTTTTTAG
+CTGGCACTAAACATGGTGGCTTCCCAATAAAGGCTCACTGGCATTATTATATGGAAATTA
+TTTTTATCATTAAAGGATCTTCATTAATAAATTGTAATAATAAGGAATATGTCCTCGAGC
+CTGGAGATTTAATTTTATTTCATCCACAAGCGGTGCACTCTATTTTTTCAGCTTCAAGCG
+AACCTTTAAAGTATGGTGTACTTAAATTTGATATAAATAATCTTCATATAAATAGTAACT
+ATACTCCAAAACTTGGCTCAATATTCAAATGCGCTATAGACGATCCTTATGCACCTATAT
+TACTTCCATCAAAATTATTTAAAAATTCACCAGAACGTTTATTTAATAGCTGCATTGAAG
+AAGTAGTAATTAAAGATTATGGTTATGACATTCGCTTTCAGTCTTTAGTTTCATCTCTAC
+TGATAGAAATTCTTAGAATATGGAGAAAAACTGGATTTGATACGAATAACATCACTTTAA
+TGCCCTATGATACTGATTCGTTACATACAATATTACAATATATAGATGAGCATTCACATG
+AATCAATAAAAGTAGAAGACCTTGCTGAAAAATGCCATATGAGTTATTCGTATTTTGCAA
+AAAAATTTCACGAATTGTATGGTCAATCCTGTAAGGACTATATTGAATTTATAAGATTGA
+GCAAAGTTAAAGATTTATTATTATTTACTAATTTTGATTTAAATTATATTAGTCAAGAGA
+CGGGATTTGCGGACTGCAGTCATTTAATTAGAACGTTCAAAAAAAAGACAGGTATAACAC
+CAAAACAGTTTAGAATGCTGCACATTATAGATAAATAACATGTAACTTATAGTTATGCGT
+ATAACTAGCAAAAAAAGAAAACCCCCTGTTACTAGGCTGCCAGAAAAATTAATTGTTAAT
+TCATTCCAATAAAAGTTGTGTCAACCATGAATGCTCCCGGTGCAAGCTCGTGACAAGCGG
+CGATAGAACAACTTTTATTGAAGAAATACATACAATTATTTTTTCAACACAACACTTCGT
+AAAAGGGCACCTTCTCTTTCTAGTATAGTATATATATCAAAGCATAAGTATGATTTTTAA
+CTAGCTTATCTACAGTTTCTATAAATTACTACTTAAGTCTAGTAAATGTTAGAACTTGTA
+TATCTGTAACCCAAAATTCCTACAAGCTAGATTTCAGTTTAGCTAGATCTTCTAAATTTA
+TAACATATTCATCGTTGTAGAATTTCATCAATTCTTCTTTGGTATTCCATTCTAATTCTT
+TAACAAAGTTATTCCAAGTCATAAACCATAGCCAATGAGTTTCTGTTTCCTTAAGTATTT
+TAGGATCTGGAATCGGTCCATTTTCACTTAGAGCTACTGGTTTTACACTATTTGGAATAG
+CTTCTGTATTTAGAAATTCAATTGTTAGTGGGCCATGATTTTCAAGAGGAGCATAATAAT
+CATTACTGTTAATATCTACTACATCATCTCCCGGATACCACTCTACATTGGGCGAGTTCC
+ACACCCAAATTAAATTATTTAATTCATGATAACTTACATATCTATCATACATCAACCTAT
+ATAGCTTTATGTAGGCTTGGGGACCTTTATCTCCCCACCAAAACCATCCTCCAGAAGCTT
+CATGCAACGGTCTCCATAAAATCGGAATATTGTTGTTTTTAAATATCTTTAACTGTTCAG
+CTATTGTATCAAGATCTCTTATCATATTAATATTTTCTTCAGTACCTTCAACTAGTGCTT
+TTTCTAAATCAAAGTTAGTATTTTCAGTATAAAAGCTCTTCCCTCTTCCATTCATTGGAG
+AGAACCAGTGCCAGCATAAAGTTATAATTGCATCTGTATTTTTTCCCCAAAATAGAGCTG
+TTTCTATAGTCCCCTTATTATTAGCTAACTCATCTATACACTCAAAATTACTATCAGGTG
+TTTCAGTTGCTAGTGAGTAACTTAGTAAATCAAAGCCGACTATAGCTGGAGTCTTTCCTG
+TCATTCTCTTTATATATTCAAAATCTGTTCCACTTGCCTTATTGCAATGTTGACCCGATA
+AAATTCCTTTACCATATATTTTAGAGAATATTTTCATTAATTCTATGCATTCTTTACTTG
+CATCTTTATTACTTAATACAAAATTGGGGTTATCCAAAATACAATTAGTACCCTCCGTAG
+CTATTATGCTATCAATATTCAAATATCCAATTTGCTTTGATATTTTAATCTCATTAACTC
+CACTTTTTAATTTTAAGCTTCCGATTTCCTTGATAGCAAATTCACTAGCTATATCAAATA
+CTACACTTCCATAGCATTCATCGTTAATAAAAATTCTGTGTACAGATTGTTTCTGAAATG
+CTGATTCAGAGATTTCTTCAGGAACCGATAATTCGGCTTTTGAAGGTAGAGCATACTTAA
+TTCCTAATCTGTAAAATCCATTATGTGATAAATTAATTTCAGCAGTTATATAATCATCAT
+CATTTATTAATGCAATTAAGTATCCTGAACCGCTATATCCTTTAATTATATTATTTGTTT
+TACCATTTATATGCTTAATCTCTGTAGAATCTATTATTATAAGGTTATTTATCATAGATT
+TTCTCCCTAATTCATAAATAATTAGTCTTTTAAAATTTCAGCGCTACATCACTGCCTTAA
+GTGTCCATGACCTAGATGAAAAATCCCCTATAACTCCTATAGTATCAATTCCAGAGTACA
+TTAACTCATCGCCACCTGCCTCAATATCAGTACCTTCAATTATATAAGTATATTCTGGAT
+TTAGTCCCTTAAATCTTATTTTTTTCGGAAATCTATTAGGTACTTCCAAGTCTTTAAAAT
+AGAATGCAACCGCTTCAGTCTTATCTTCTGTAACATAAATCCAAGCAGTTTCATTCCCCT
+CAAACGGGCTTAGAATTCTATAAAATTCTCCGTATTGAATAATATGACGTATTTCTTTAT
+AGCGAGCTACTTGAGATTTAACAATTTCTTTTTCCTCGTCTGAAAACTTTGTTAAATCAA
+GTTCGTACCCAAAATTTCCCGACATAGCCACATTACCTCTAGTTTCCAAGCTTGTTGTCC
+TTCCAACTTGGTGATTAGGACATGCTGATATATGAGATCCCATTGAACTTGCTGGGTATA
+CTAAACTTGTTCCATATTGAATTTTTAATCTTTCTATCGCATCTGTGTCATCACTAGTCC
+AAGTTTGCGGCATATAATATAGCATTCCTGGATCAAATCTTCCACCTCCAGAGGCACAAC
+TTTCAAATAGCACTTCTGAGAACTTACTTGTTATGGTCTCAAGAATATAATAAAGCCCTA
+GTACATATCTATGAGATATTTCCATTTGCTTGTTACTAGAAAGTCTGGCTGACCCTAAAT
+CAGATATCCCCCTATTCATATCCCACTTAACATAAGATATAGGCGCACTTTCTAATATAT
+TAGAAAGCATTTTTATAACTTCATCACATACATCCTCTCTACTTAAATCAAGAACAAGTT
+GAGATCTCTGAGCTCTTGATTGTTTTGGTTCTCTATTTGGTACATGAATACACCAATCCG
+GATGCGCACGATATAAATCACTATCAGGAGATACCATTTCTGGTTCAAACCACAATCCAA
+AACGGATCCCTTTATCAGTAATCTTATTTACAAGACTGTCTAACCCATCTGGTAATTTTC
+TCTTATCTACTACCCAATCACCCAAAGAGCAGTTATCCGAGTCTCTCTTCCCAAACCATC
+CATCATCTAATACAAAAAGTTCCATTCCAAATTCTTTCCCTGCCATAGCAATTTCTTCAA
+TCTTCTCAGTAGTAAAATCAAAATAGGTAGCCTCCCAATTATTGATAAGTATTGGTCTTT
+CTTCAAACTGATATTTACCACGACATAATCTTTCACGATATAGTTTATGATATGTTCTCG
+ACATTTCACCTAATCCAGCATCAGAATATACCATAACAACTTCCGGCGTTTCAAAAATAT
+CTCCCGCAGATAATTCCCAATTAAAATCAAATGGATTTATTCCCATCTGTACTCTTGTGC
+AGCTAAATTGATCTACCTCTACTTCTGCTAAAAAGTTTCCACTATATACTAAGCTAAAAC
+CATATACTTCACCATTATCTTCATTTGCATTCTTTGTTAAAAGAGCTAAGAAAGGATTCT
+GCTGGTGACTGCTTATACCCTTCTTACTATCTATAGACTGCATCCCCGGTACCAATGCTC
+TCTTATAAATATGCTTCTCACGACACCACGCACCTGATAATTGTAACAAATCAAAATTAG
+AATGTTCTAAATCGATGCTAAAACTTAAAGCTTTTCGCAAATTTATCTTCTCTCCATTAG
+ACTTGCTATTTACAAACTTAGCATATCTAGTTATAACATTATAACTATTGTAAATAGTAT
+ACGATAAGATAACCGTAAGCCCCGCAATATCATCACTTAATTTTACTTCTAGTGTTTCAG
+CTTCCTCTTTATTATTAACATAAGTTGCAGGTAAAGACTCCATTTTAGATTTACCAGGTA
+TAATATCATGTTTCACGTATTTTAATTCGCTAGTACTAGCTCCATTCTCAAGAATTGCTT
+CATAACTCGGCGTCCTAAAATCCCCTGAACCAAATGCCGAAAATTCTTGTGGTACTACAT
+CTAAATTGGTTTCTTCAACACTAGATGAACCAATTAGTTCATAGCTATTAACTCTTTTCC
+CATAATATCTATGAGCTAAATAGCCCTCATTGGTTATCTGCATCACATAACTAGTTTCGT
+CATTGCATAAATGTAATGTTTTACTCTTTTCATTAAAACTAATAGGCATAAAATTTCTCC
+TCAAATATACTCTAATTTCAAATAATTTTGTATAAAATCATTTACATATACTATACCAAC
+TTCACTACTAAGACGATATAACACAACTTACTAAAAATAGAACAAATCTATTTTGAGAAT
+TTACTAAAACTTTAAGTTAATTTTTACACTTTCAATAAGCCATATGTTATTTACGTATAA
+AAATAAGGTATTACCTCCACTTCCGCAAGTAGCTGTAATACCTTATATTCTTTCTTTATG
+AAACTAATATTCCTAAAATAGTTATTTCTTTAGCTATATCTTCTTTAACCACATCAATCT
+CAATTTTATATCTCTTAACTTCATCATTCAATTCTAGTATTTCTGTTGCCGAATAATCCC
+CCCAACCATCTTTAAAATAAGTATCTAAAAACGCCTTGCTCTTACCATTTACACTTATAT
+TGATTTTCCCCGAGTTTATAGAAATGCTCTTTTTATATAGTAAGATAATGTTTCTCGCCT
+CTAACTCAAAAACTAGTTTTCCATCTTTATTATCTTCTATAGTATATTTCCACCCATTTT
+GAAACACTTGAAATCCTTCATCATAATTATCAAATCCTAACATTTCTTTTGGTTGAATAT
+TAGCATTATTAATTATTATTCCATTTATATATCTATCTTCGAACACACAAGGAGTATTTA
+AAACATTATCTGTTATTTTTATAATCTCTCCATCTTTATAATCATTTTCGTAGATATTAT
+TAATAAAATTTATCAATAGTTTAGATATTATATAATGACCATCATCATTAGGATGAACTT
+CATCAGTTAGTACATCAGCAAATTTCATTTTGTTTTTCACAACCTCACACTTTAGAGCAT
+CTCTAAAGCTTATCATCGGTAAGTTATATCGCTTTCCTATTTCTATTTGTTGTTCTTGAA
+CATTAAACCCTGTATCCATCGTCATAAATACTTCTACTACTGCCGGTTTATTTTCGCTAG
+TTAATAATTTTCTAATTAAGCTTTCGTAAGCAACCTTACACGAATAATCTTCATGGTCAT
+TAACTGCGGCATCAACAAAAACTATATCTGGATTTTGACTTATCACCTGCTTTTCTACTC
+TGTGAACTCCTATTAAAGATCCAGTTGCTCCAACTCCTGCATTTATATACCTAACATTTA
+CCCTATTGAATTTTTCTTTTAACCAAGCATAAGTTAATTCAACATAACATTTTTCCTGAA
+CTGTTGAGTTACATCCCTGAGTTATAGATCCTCCTAAAAATGCTACTATTAAATCTTCTC
+CCATCTCAGCTTTTCTGATTAACTTTAATATTCTACTTATATCCCCTTTATTAACTAATG
+AACTTTTAAACATTTCTTCTGTTATTTTAAATCCCATGTGTCATCCTCCTAACAACTTTT
+TATATAATTAGTTAATTTAATAGTATTTTAACTTAATCGTTTAAATAATAATTGAATAAT
+TTTATTAATATAAGTATAATGATTTTTACAAACATAAACTTGCATTATTTCAGCAAATAA
+TAACACTATTTTGATATTAAATTGAATTTATAATAAAGAGGTATTATTTATGAATAAAAA
+TATTTTTAAAGAAACTATGTATTCTATTGATTCTATGTTCCCTTTATATAGTTCTGATAT
+TAATATTGGGGATAAAACAAACCCGCTTAATTGCCACTGGCATGATGAAATTGAGTTTAT
+TTTAATAACTTACGGAAAAGCCATATTTCAAATAGAAAATTCCTCCTACGAAGTAAACGA
+AGGCGATATCATCATCATTGGATCTGGCGAACTTCATTCTGCTTACAGCCAAAGTTTTAG
+TGATTCGTGTATTTGCAAATCATTGACTTTTAATTGTGATATGCTAAGCAGTAAAAGTAG
+TGACTCGATTCAGATTAAATTTATTAATCCGTTAATAAATAATCAATTGAACTTGCCTCA
+TCATTTAAAATGCATCAACGATAACGAAAGAATGATAAGATCATTTTTATTAGAATTAAT
+GTCTACACTGAGTATTAGAGAAAGCAACTTTGAATTAACAGCTAAATCATATCTATATAT
+GATTTTTTCAAAAATAATGCTTATGGTTACTCATAAGAATGCTAATGAGTTATTAAATGT
+TAGTAATTCAAATAAGATAGATAACTTTAAACATGTTCTTAACTATATTCATATGAACCA
+CAATAAATCCCTTACAATAAAAGAGCTATCTCTGCAACTTAATATGAGCGAAGGGCATTT
+CTGTCGTATCTTTAAATCCCTAACTTTTAAAACTCCTATTGATTACATTAACTACTATAG
+AACGACAAAAGCGCAGGAGTTTCTAATAAATAGCGATAAAAAAATCTTAGAAATCAGCAT
+TGATGTTGGTTTCAATAATCTTAGCTACTTCATAAATATTTTCAAGAAGAACACTGGCTT
+TACGCCATCTGAATTTAGAAAAAAAATACATCTTCGTGGAGCAGACATTGAAAAATGAGC
+TACTATATATCTTATATAATATTTTTAAGACATATTGTAATTATTTACACAGTTGTGTTA
+TTATTTATTATATAAGCTAAACGTTAATTCTTAATTTAATCAATCTTTTTTGCTAATACA
+TACTTCCAATGCAAGCTACATCAAAATTTCATAATACTTAAATTTACGTATAATACTGTG
+AATATATAGGGGGGACAAACAAATGATTAAAAAAATACTGAAACCAGAGAAAATTAAAGT
+AAAAATCTTCAATTTTAAGCCAACAAATCTCAAATATATTAGCTTAAATTTTGTAAAAGA
+AAAATTCAAAAATCTATCTATCCGCAAAAAGTTATTTTACTCTTTTATGTTAGTATCATT
+TATCGGAATAATTTCCGGATTAATAGGTTTGACATTTATACAAAAAACAACCAGTGAATA
+TAATTCTGCTTTAAAAAATTACGGTTTTTCTCAAGGTGACATAGGAAAACTTGGAATAGA
+AATAGAAAAGTCTAATTCTTTAGTTAGAGATACTTTATTTTTAACTGATGCTAATGAACA
+AAAGGATGCCAAAAATTCTCTTAATAAATCTTTAGATGAAATCGAAGAATTACTAAATAC
+TGTTACAAAATCTGTTACTTCAAACGAAGAAAAGGAAATATTAAACAGAATAAAGATCAA
+TCTAGCAGCATATAAACAAATCAGAACCACTGTTGTTGTAAAAGGTTTAGCAAACGATAA
+AGAATCTGGGCTAAAAATCTTCAAATCTGACGGATCCATCTTGATGAATAAAATCAGCTC
+TGATATTTCACTCTTATTGCAAACTAAAATAGATACATGTAATCTACTTTCTACCAAATT
+AAATGTTTTAAAATTTGTTAGTATAATAATTGTTATTACAAGCATGATAATTTCTTTAAT
+TCTTGGCATTTTCTTAGGCAAAAATATTATAAAATCGATCAGCAACCCTATTGATCATAT
+GAAAAATGTGGCAAGCGAAATGGCTAATGGTAACCTTGAAGTTTCAATAGATATATCTTC
+AAATGATGAAATAGGTGAATTAGCTTTATCTTTCTCTCAAATGATTAAAACTCTAAAAAA
+ATATATCACTGAAATATCTACCGTTTTAGGCAGCATTTCTAATAGAAATTTTGATATCCA
+TATTATAGAGGATTACAAAGGAAATTTTATTCAAATAAGGAGTTCACTGGACAATATAGT
+AGCATCCCTAAGCAATGTATTCTTAGAGATTAAAGATGCAACTATGCAAGTCAATAGCGG
+AGCTAGTCAAGTAGCTAGCACTTCGCAGATTATATCAGAAGGGGCAACCGAACAAGCTAA
+TTCTATCGAAGAATTATCTGCCTCTATAGAAACGATTTACAACCAAGTTCAAAATACTGT
+GACTACTGCGGATAATACTAATTTAATTACCATGAACTTAGTTAAAAGTATACAAAATAG
+CAATTCCCAAATGAATCAAATGCTTTCTGCCATAAATGATATAGAAAGATCTTCTAAATA
+CATCAGCAATATAATTAAGGCAATTAGCGATATAGCAACCAAGACGAATCTTCTTGCTTT
+AAATGCTGCCATCGAAGCCGCACGAGCTGGTGAGGCCGGTAAAGGTTTTTCCGTAGTAGC
+CGATGAAGTAAGAAAATTATCTTTCCAAAGTGCAGATGCAGCTAAACAAACATCATTACT
+TATTACCGATTCTATCAAAGCTGTAAATAAAGGTAGAGATTTAGCCAATAGCACTGCTAA
+AACCTTATTGGAAGTAGTTAATAGTGCGACTAATGTTACCGAATTAATATCAAATATTAC
+ATCAGTCTCTAAGGCCCAGGCCAATTCAATCGATCAAATACATGATAGTATTTTAAAAAT
+ATCTGATGTTGTTCAATCAAATTCAGCAATAGCTGAAGAAAGTGCAGCTTCTAGCGAAGA
+ATTGACTGCCCAAGCTGAAACTTTAAATACAATGGTAGATAAATTTAAGCTTAAATCCTA
+AATAAAAAATAAAACAGCCGATAGCTTTACTGAATGTAAAACTATCGGTTAAATAATATA
+ATAAAACTTATATTCCTTTTTCACTTTTATTCATAAGAATACCGGTGCAAATGGGCTAAT
+TTCTCTTATGAATTTTTCTCTAATTTTCTAACGGTATCTTTTATAACAATTTTTCCACTT
+ATAACTCTTCTTGCCGGCTTATAATCGCTCTTATGCACTTTCTTTATTATAGCACCAACT
+GCCGTTTCAGCCATTGTCTTCATATCTACTTCAAAAGTTGTGATCCCTAGGTCTGATAGT
+TCTGTTATTAAATAGTTATCAAATCCAACTACAGAAACATCTTCCGGAACCCTATATCCT
+TTATCCTGTAATTTCTTAATCAAAATATATGCTACTGAATCACAATTACATGCAAAAGCA
+GTTGGCATTTTCTCTGGCAACTCAAAATTTATTTCTTTCTTGCCAACTTCTCTATCTGAA
+ATATAACTATTTGAAGAATAATCAATACCATTTTCAAGTAAAGCCTTTGTAAATCCTAAA
+AAACGATCTTGAATGCTGCTTGTAGCACGTGGATTTCCCACAAACGCAATATCCCTATGA
+CCCATTTCAATTAAGTAATCAGTTAATAAATACATCCCATAATAATTATCCGAAGTTACA
+GTATCATAGTTACTATTTTTATCGTATGTATCTAACATCACTACAGGAACTTCATTAAGA
+TCATTTAGATATTCTATATAATCTTTTTTCAATTCTCCCATAACTATAATTCCATCTATT
+TTACTATCTTGTATCATTCTTGGAATTACTTTATTATTCTCATCATCTTTGCTTATAATC
+TCCATAATCCCATAATATGATTTTTTAGTTAATGCATTTAATACATTTTGATACAACTCC
+CAATAAAAGGAATGATACATTTCAACAAATCCTTCTGGAATTAGCACCCCTACATTATAG
+GTATGACCATCTCTTAGAGATCGCGCAATAGAATTTTGACGATATCCCATTTCAGCCGCA
+ACTTTCTTAATTTTTTCCCTTAATTCATCACTAACTCCCTCTTTGTCAGATAGTGCTTTA
+GAAACTGTAACTTTACTTACATTTAAAGCTTCAGCAATGTCAGCAAGTTTAATAGCTTTT
+GCCATATTATTCATTCCCTTCTTGTTGTACGTATAACTAACTATCATAGATGCTGCTTGT
+TTACTAACTATGATAACATACGGAATTATCAAAATATTTCAATGTTGTTGTTAAACTAAT
+CCACTTAATAAATTTTATAACTTTACACATCTGCATTTAATATATTATAGAATGATGGGT
+ATTATTTAATATTTTCATATGATAAAAAAGTTTTTAACTATAATTATTGTCTATAGTCAA
+AATTTTATCCTATTCTGTTTAAAAAATTTTCTGCTCACATTCAATTCTTTATAAATAAAC
+GGTTAGTTTTCATTGTTCTCTAATATTATACAATAAAAAGCTGTATTTCGCTATTAGTAT
+ATACTCCAAAAGAGTTTTAATTTTAGCTAAAATACAGCTTAATAATTTTATTTTTTTATA
+TTCTTACTTCACTTTTTAAAGTTAACGTTTAAGCGGTTTATAAAAAAAATTATAATTTCC
+CCTCTTGCCCGTCTATCGTTCCAAGTTCATTATGTTCTTTAATAAACTTAACAGTTTCAT
+CAATAGTAGTATACGCCAAACCTACATACGTATCCGCAGCACCATAGTAAATAGCAATTC
+TTCCTGTTTCAGCATCAGTTAACGCCGCACATGGGAATACTACATTGGCTACAAATCCAC
+GTTCTTCATACCATTCTTCTGGTGTTAACATTATACTTCCAGCCCTATATAACACTTTCG
+ATGGACAATTCTTATCTAATATTGCTGCACTCATAGAGTAAACCAAACCGTTGCATGTTC
+CAGTTACACCATGATAGAACATTAACCATCCTTCATCTGTTTCAATTGGTGCAGGTCCAC
+ATCCAATTTTAATTGACTGCCACCATCCTGATCCACCTTTTTGCATTACTATTCTATGTT
+CTCCCCAATATTTTAAATCAGGACTTTTGCTTAAGAATACATCCCCAAATGGAGTATGTC
+CATTATCACTTGGTCTAGATAACATAACATATTTTCCATCAATTTTCTTAGGAAATAAAA
+CTCCATTACGGTTAAATGGCAAGAATGGATTTTCTAGCCTTATAAATGTCTTAAAATCAG
+TTGTTTTAGCTATTCCAATTGCGGCACCATCAAAATCCCCACACCAAATAATATAATACG
+CGTCCTCGATTTTTAGTAATCTCGGGTCATATGCATAAAGTGGTTGATAATCACTTCCTT
+CTTCATCTACAAATTTTATTTTTTCTTTTTCAAACTCCCAATTAATTGCGTCTTTACTAT
+ACCCTAAATAAATATGTGGTCTTCCATTTATAGTTTCGCCACGGAACACTCCTATAAATT
+CATCCCCGTAAGGCATAACTGCACTATTAAATATTCTAGCTACACCCTCTACAGGATTTC
+TTTTAATAATTGGATTTTCAGTATGTCTCCATATTGGACCATTAAAGTTAGCTGGCTTCT
+CTTGCCATGGAATATTAGGTAGATTTTCGCCTAAAATTTTACTCATATTAATTCACCTTT
+CTTAAGAAATAGCCAATCTTATGTATTATTATATAATTCTAAAGAATACACAATTTAAAT
+AGCATTTCTTTCTATATTTATTATTATTTATTAGCTTTGTTATAAATATAATTAACTTAT
+TCTTTTACTGACCCCGATACTAATCCACTATAAATATGCTTTTGTAAAGTAACAAATACA
+AGAAACGTTGGAATCATAATCAGAACAATACCCGCAGATATTATTTCCCAATGGGCACCA
+AATGGTCCTTTAAACTTAAATAACGTTGTTGATAACGTTAATAAGTTTGGGCTAGGTGTA
+TATAAAAATGGTGTGTAGAAATCATTATAAACACCAACACCTTTTGTGATCATAACTGTT
+ACTATTGCTGGGGAAAGTAGCGGAAGAATAATTTTATAATAAATTTGAAAATAGTTTGCA
+CCGTCAATAATCGCAGATTCATCTAACGAAACTGAAATATTCTCTAAAAATTGTAGGAAT
+ATATATATAGTCATTATATCAGTACCGCAATATAGAATAATCGGAGCTAATCTAGTATTA
+AATAAACCTAACGCATGTACAATCTGGAATGTTGCAACTTGTGTTGCTATCCCTGGGATC
+ATTACAGCAACTAGGAACATACCATTTACAAATTTACTAAACTTTGTTTTAAATCTGCTA
+AATATATATGCTGCCATAGATCCAGTAAGTATTGAACCTATTAATGAAAATACTAAAACA
+AATAATGTATTTTTAAAACCATTTACCATATTACCTTTTTCAAAAACAGCTTTAAAATTA
+TCTAGGTTAAGGAAAGACTTAGGTAATGCTAACGGGCTTGTAGTAGTATATTCAGCACCA
+GTCTTAAACGCTGTAAAAAATACACTTAATATAGGAATTATAAATACTAGTACAAAAAAG
+ATTAAGATGGCATATTTAATTACTTCATAAACAATCTCTTTTCCACTCATTTTTTTTATT
+TTCATACTCTTACATTCCTTTCCTTTTCATAACTGCATTTTGTATACTAGTGATAATTAT
+ACACATCACCAATAATACCATTGCCATTGCTGAAGCCAGTCCCACTCTATGATTTTGGAA
+TGCATACTGTACTGTTTGAACTATGAAAGTCATACTTCCATTTCCACCATTGGTCATTAT
+ATATGGTGTTTCAAACGCTGATAATGCTCCCGTAAGCGATAAAAATAATTGTAAACCTAG
+AATTGTTGAAATACCTGGTATTATTATATATCTAAGTTGTTGGAATCTATTAGCTCCATC
+TACTCTTGCCGCTTCTAATACATCTGATGAAATAGATGCCATTGCAGCCGAAAACATTAC
+GATATTATACCCAATATATCTCCATACCGATACAGAAGCTAATGATATATTAACAATACT
+CGGATCCTGTAACCAATATTTCACGAAACCACCTAAACCAACTGCCTTTAAAACAGTATC
+TAAAGTACTATTAGGTTGGAAAAAGAATATAAAAACAAAACTAATTGCAACACTATTTAT
+TAGCGATGGGAAGAAATATACACCTTTAAATAAATTTGAAAATTTACACCCAAATGAAAC
+TAAGTATGCAATTGCAATACCTAATGCGATTTGAATAAATGATGCAACAAAATAATATAT
+ACTTACAAATAACGGCTCAAAATATTTAGCATCACTCATTATAAGCTTATAATTTTTAAG
+CCCTACAAATTCCTTAGTCTTAGAAATACCATCCCAGTCAGTAAAACTATATCCAGCCAT
+TGCTATTGCCGGCAAATAAGTAAAGACCCCTAATAGCACTACTGGTACCATTAAAAACAG
+GACTGAAATTATAATTTTTTGTTTGTTATAAGGCAATGAGGAGAAGCTAATTTTTTTCTT
+CATATTGCTGGTGCTAGTTGCTGCATTTTTAGTATTTGCTGTGGCATTTTCAGCATTTGT
+TGTCATAATAACACTCCTTTACTCTTAAATTAAAAAGGCGATATTTTATTTTATTTTATA
+TCGCCTCTTTTCAAATTAATGACTACATTAAAATACTATTTACCAATTGAGTCTACTCCA
+GTAGCCCAGCTCTTATTTAATGAAGCCATATATTCATCAAAAGTTTGTTTTCCATTTCCT
+AAACCAATCTCGATTACTGTTTTAACCCATTTACTATCATTAAGGTTAAGTAATGATTCT
+TTTTGAACTTTATCTAAATCAGTAGCCATTTGTGTAGTACCCATCTTTTGTTGAACTAAT
+GTTGCTCCTGATCCCGCTAAGAAGTCTGGTAATTTTGCACCAACAAGAGAAGAAACCATA
+TCCGAATCGTTTGGATATTTTTCTACGAAGTATTTTACGAATTCTTTTGCAATTTCTTTG
+TTTTTACTATGAACATTTACACCCATCATATAATCTGGGGCAATTTGCATAACTTGTTTT
+CCATCATGTGATATAGGTGATGCCATAAATTTAATGTCTTCAGGTGTTTTAGATTTAGCC
+TTCATTTGACCAACTGCCCATGATCCTAAAGCCATTACACCTATTTTACCATCAGCCACC
+ATTTGCTTTGAAGTCTCCCAATCTGTTGTCATCGGATCTTCTTCAACTAACTTATTAGCA
+ACTGCATCATTTAATAACTTTAATGATGTATAAAGAGGTTGCCCTTGTGCAAATACATTT
+TTGTCATAAATCATTTTATTTGGGTAGTCTACATCACCTGACGCGTTAACTAATTGCGCC
+GCAGACCAGTTAGTTAAGGCCCAGTCATCTTTATAGTTTGTATACAACGGAACTGCAGAT
+GTCTTTTCTTTAATGGCTTTTAAATCAGCTATAAATTCCTCTGGTGTTGTTGGAGTTTTT
+GTAATTCCAGCTTCTTTAAAAACCTTTTCATTATAGAGAAAACCATTAGCGTTAGCACCA
+GTTGCTAAACCATAAACAGTTCCATCTACATCTGCATTATCAAGGAAATCATATTTACCT
+TTAAGTTCTTCTCTAGTTCCAATTGGTTCATAATAATCTTTATATTGATTTTTAGTTATG
+TTAGCAGGCAGCATTAAAACATCACCATAATCTTCTGTTCCCATTCTAGTGTTCATTGTA
+TTTTGATAATCGTTTAACGCTTCAAAATTAACTGTGGTTCCAGGATGTTTTGATTCAAAC
+TCTTCTTTATACTTTTTAAAAGTTTCGTCCATGTCAGTTCTATGTGTTAATACTGTAATA
+GTTCCACCTGATTTTCCATCACTTTTTTCTGATGTACTAGTACTACTGCTACCACAACCA
+GTTAGCGATCCAACAGCTACCGCACCAGCTAATAATAATGCTAATTGTTTACGGATTTTC
+ATTTTTCATACCCCTCTTCTTTTTTAAGTTAACGTTTAATCGTTTTTAGTATATATTCAA
+ATTTAATAATTGTCAATATTGTTAACCATAATTATATTACTTTTTAATTAATTTAACTTA
+AATTTTAATTATTTTTTTAATTTTTAATTAACTGATTTTTATTACTCTCTATCCTCACTA
+TTCCTCTCCTTTTCACTTTTTAATATATATTTTTTTATTCCATTCCAAGCACAAAAACTG
+CTCAAAAAACTGCAAAAAGAAAATGTGAACAAAAAAAGAACAGGTATAGTGAATGGACAA
+AATAAAATACTTATTTCTATCAGAGATATGCATAGTATGAATGTTACGAAAGAATATTTC
+ATATACACAACACTTAATAACATTGAATTTTTAACAATTATCCTTAATGGTAAATTTATA
+CCTATACTCATTGGATATATGTATATCAATATAATACAGAAGAATACTCCTATTATGATA
+ATAATTGAAGTTGCTATACTATAAATTAATCCTTCTGTGGCAATACAAAAAGCTAACAAC
+CTTCCTAGAATCACCATAAATGCAATCACAAATAACCAAACAAGAAAGGATTGCTTCCAA
+TTTTTCTTAAAAGCCTCCTTAAAATCATAAAATAAATCTGAAGGTTTATCCTGCACCATT
+TTAACTGTTACTGATGTCATCGCTCCAATAGCGGGGCCAATAGATATAATAGGAATACAG
+CAAATTATAAACAGTAAGTTCAATTTAAGCAGCGACGTAAATTCACGCGCAAATATATCC
+CCAAATAAGGCCAACCCCTCTTTAGGTGGTGCATCTTTGGAAACACCTCGCCCCTCTTTA
+TTGTAATCAAAGAAAAATAATCTCATAATGTACCTCCAAGTTAGGTTCCAACCTTAAAGC
+ATTAAATTTATAATAAAGCTACTTTACCCGTTATAAGTTCTATACAGCCAAAGATTGTCT
+ACCAATTATCCAAGGATGTTCAATATAGAAAAATAGTTGGTAGCACGAACAAAAAATACC
+ACATTAAATTCATCAAGCTAATCTATACACTTAGATTTTATCAACCACTCTATTACTTTT
+TCCAACTAGATTAATTTCAAATTGTTTTTCCTGTCTCTTTATCAAATAAATGCATCTTAT
+ATTCATCAATTGCTATCTTTATCATATCTCCAGGTTCTACTATAGTATCTGCTGATGCGC
+GAACAGTTAACTTTTTGTTATCGAAATTAACATAAAGATACACCTCCGCTCCCATTAATT
+CATGAAGGGCTATTTGAGCATATAGTGTACTTTTTTCATGTTCTTCTAAGAAATCATTTT
+CTATGCTGACATGTTCTGGCCTAATTCCAAGAACAACATTTTTTCCAATATACGCTTCAA
+AAGTTTCCTCTCCACCTTTACTTTTAGGAATAGGAATACTATAGCTATTGAATTTTACAT
+AGTATTGGTTATCTTTCTTTTCAATAGTTGAATCTATAAAATTCATTTGTGGCGAGCCGA
+TAAATCCAGCAACAAATAGGTTAGCCGGCGAATCATACAACACCATTGGCTTATCTGCTT
+GTTGTATGTATCCATCTTTCATAACTACAATTCTATCTCCCATTGTCATTGCCTCAATTT
+GGTCATGAGTAACATATACAAAGGTAACGCCTAATCTCCTATGGAGTTTAGTAATCTCCC
+CTCTCATTTCAGCACGAAGCTTTGCGTCTAAATTCGAAAGCGGTTCATCTAAAAGAAAAA
+CTGCTGGTTCACGAACCATGGCTCGTCCTAAAGCTACACGCTGTCTTTGACCTCCTGAAA
+GCTCCTTAGGCTTACGGTTAAGTAAATACTCAATATCTAATATTTTAGCTACTTCTCTAG
+TTTTCTTATCTATTAATTTCTTATCTTCTTTTCTTAAATTTAGTCCAAATCCAATATTTT
+TGTATACAGTCATATGAGGATATAATGCATAATTTTGGAATACCATTGAAATATCTCTAT
+CCTTAGGTGAAACCTCATTAACTAAATTATCCCCAATATATAGTTCCCCTCCACTTATAT
+CTTCTAATCCTGCAATCATTCTTAACGTAGTAGATTTACCACATCCTGATGGTCCAACAA
+GAACAATGAATTCACCATCATTAATTTCTAAGTTTAGATTTTTCACAACGGTTGCATTAC
+CAGGATAAGTTTTTTCTATATTTTTAAGTGAAATACCAGCCATATTACGCCTCCTTATTT
+ACTTGCGTTGTTATTAAAACTATTTTTAGGTTAACGTTAATCTAAGAATAAATATAATAT
+ACCATTGTTTTTTAATCCTTACAAGATTTAAAATATTATTTTTTGTAGTTTTTAGCCCTT
+CAATAATTTTTAATCTTTATTGCTTACTATAGAATTTTCCGCTATCACTCTTAGTAAACG
+TTCTCTTATAAATAGTTTATTTATTCTATCAATGCACGTCAATGTTATAGTAATAATAGT
+TTATTTTTCGGTATTTTTGCATATTTCTATGTTAACTTTATAATCTAATTAACTTAATTT
+TTACAGAACAAAATTATTTAATTTGTTAATAATATTTTTTTACTGTAAGATCTTTATAAG
+ACCTAATGATTAATACATTTTAATTTAAAATTACCTTATCGTTATACTTTTTTTAACTTT
+TTTCTATTGACTTTCATAGTGATACTAAATTATAATTTGTCTGTAAACGATATATCATAA
+AAGGGGGAAAAGTTATGATTAAAAAATCTAAATTCAAACTAATGCTATCTTTGTTACTGT
+TATCTGCATCGATGTTTACTTTCCAAACTCCAGCTAGTGCAGCCGAAGACTCTTCATGGA
+TAAGAGGCACGAACGTACCTGCAATCTGGTATGATAGTCAATCCTATTCTTCTCTTAACA
+AAATTAATAGCGAAGGATTTAATACTGTTCGTCTTGTTTGGAGCACTAGCGGATCAACTT
+CTAGATTAAATGATTACCTTACAAAATGTGATAATTTAGGCCTTAAAGCAATAGTTGAAC
+TTCATGATGCAACTGGTGGTACCACTACAGACTCGTTGAATACTTGTGTGAATTATTGGG
+TTCGTAGTGATGTATTAACAGTAATGAAGAATCACCCTAAGGCTTGGTTAAATATCGCTA
+ATGAATGGGGTCCAGCTAACAGTAGTGTTTGGAGAGATGGTTACAAAAGTTCTATAAGTA
+AAATACGTACTGCTGGTTATACTGGTACTATTGTAATCGATGCAGGCGGATGGGGACAAG
+ATAGCAGTGATATACTAAACTATGCTCTTGATGTGTACAATTCCAATACTAATAAGAATG
+TTATATTCAGCATACACATGTATGGATCATGGAATAGCAATTCAGATATAGATTCATTCT
+TAAGCAGTTGTAAAAGTAAAGGTATTCCAATTATAGTTGGAGAATTTGGTTATAACTATA
+ATAGCGGTAATAATAATCTTGGTTGCAAAGTTGATGTTGCTCATTTATTAAGTTATTGCA
+AACAAAATAAAATCGGATTTATCGCATGGTCTTGGGCTGGAAATGATTCTGCAAATTCAT
+GGCTAGATATGACTAATTCTTGGGGAAGTTATACTTGGTGGGGACAATATGTAAAAGATA
+ATATGTGGTAATATATTATAATCACATATGTTGCTTTGTCTCGGATATAAAGAGATATTA
+TTCTATAGATATTCCATGAGAAAGGAAATCATATTTTGAGCCAATAGCAATTTTAAACTA
+CAAAAAAGAATTAGTGAGCTAACTAAAAAAATACTTATTTTCTATGAACGTCTCTATGAT
+ACAGATATCTTCCATTGAAATTTAAAATAATATTTAAAGAAAAATTACCGAAACGTTAGC
+AATATAGTTTATCCATTTTGTGAAATTACCTTGCTTCCATGAAAAACAAATATATTTCTT
+CATTCAAAAATTAATTGCTTAATTATATTATAAAAAATTTAAGTAAAACCTTATAATTTG
+CAACTATATAAAATTCATAAACATATTTTACAAAAGGAAGTAAAAGTAAGTTAATCAAAT
+CTTATTCTTTTCATTTCCCAAAATATACCTTTCTATTCAACAAAAAAATCAGAACTTTTT
+CAACAAGTCCTGATTTTTTATTTATATAGGCTTAAATATCTTATAAAACTGTAACTATTT
+CAAAGATCAACCGTTTTAGTCAATTTGTGCTTAGCATAAATACAATTACAATTTTTCTCT
+TCTCTTTGTAGACTTTATAAATATCTCTTTTAAGGTTTCTTTGTCATCATATTTTATTGC
+ATCTTTTATTTTATCCAATTCTACTTCAAAATTTTCAATGCTTTTTAATAGATTCTCTTT
+ATTTCCAAGGAAAAGTTCGCTCCAAAGGTCTTCATTTATATTAGCAATTCTTGTTAAATC
+ACGATAGCTATCTCCAATGAAACTTCCTGTTTCTCTTCCTTCAACATCGCTATTTACCAG
+TGCTACAGCTAATGAGTGCGGAAGCTGACTTGTGTAGCCAATCATTTCATCATGATATTC
+TGGAGTTATTCTTTTAACTCTTTTAAATCCAATTTTATAAATCAGATCTTCCACCATGTT
+TAAATTTTCTTCTTTATTTCTAGAAACCGGTGTTAAAATATAATTTGCACCTTTAAAAAC
+TTGGCTACTTGCAAAATCTATTCCTTTTTTCTCCCGTCCTGCCATTGGATGGCCAAAAAC
+AAAATCTATATTCTCCGGTAATATATTTACAATATCTTCGATAAACATTTTTTTAATTCC
+AGTAGCATCTGTTATTACTGCACCATCTTTAAAATTGCTTTTATTATCTATAATAAATTG
+CTTAACTAATCTAGGATATAATGAAATAATTATAAAATCTGCACTCTTAATTACTTCTTC
+TCCGTTTTTAAAACCTTCTCTTATTAATCCAAGTTTTTTAGCTTTTTCTAAAGATTCTTC
+ATTAATATCTATTCCATAAACATCATTATACCCAGCTTCTTTTAAAGCCATAGTAAATGA
+TCCCCCAATTACTCCAAGACCTACAACTACTATTTTCATATCTATAGCTCCCTTATATAG
+AATTAGATTTGCTTATCTTCAATTTTTGCTACAGCTTTAACTTTACTCATTAGCACATCA
+AATTGATCTGGAGTAAGTGATTGTTGTCCATCGCTTAGTGCATTTTCAGGATCGTTATGA
+ACTTCTATCATAAGTCCATCAGCCCCAGCTATAATTGCTGCTTTTGCCATTGGTTCTACC
+AAGTAAGCATAACCTCCTGCATGACTTGGATCAACAATTATAGGTAAATGTGATAATTTC
+TTAATTACTGGAACTGCTTGCAAATCTAATGTATTTCTTGTAATAGTTTCGAATGTTCTT
+ACTCCTCTTTCACAAAGAATTACATTTTCATTTCCACCTGCCATGATATATTCTGCTGAC
+ATAAGCCATTCTTCTATAGTTGCAGATAAACCTCTCTTTAATAGTATTGGTTTATTTGTT
+TTACCTATTTGCTTTAATAGATCGAAATTTTGCATATTTCTAGCACCAATTTGAATCATA
+TCCACTTCTTCAACAAAAGTATCTACGTAATCAGTAGACATAAGTTCTGTTACTATAGGA
+AGTCCTGTTTCCTGTTTTGCTGTTTTTAAAAGTTTTAATCCTTCAAGCTCTAAACCTTGA
+AAGCTATAAGGTGAAGTTCTTGGTTTAAATGCCCCACCTCTTAAAAAGTTGGCTCCTGCT
+GCTTTTACTCTTTTTGCGATTTCAACAATTTGTTCTTCACTTTCTACAGAACACGGTCCA
+GCCATTATTCCAAGTCTCCCACCGCCAACTATTGATCCCTCAATATTAACTACTGTATCT
+TCAGGCTTAAATATCCTGTTTGCTTTCTTAAAAGGTTCTTGAACCTTCATAACCCTATCT
+ACACCTTTTAATACTTGTAATTTTTTAGGATCTAATATTGAAGTATCACCAACAGCTCCT
+ACTATAAAATATGTGTCTCCTTTAGAAAGATGAGC
+>NODE_16_length_39898_cov_63.337_ID_31
+CGCGCGCGCCGTTATTCAGTAGCTCTTCTGCCAGCGAAATCCCCATTTGTTCGGCATCTT
+GCGGCGCACCGCGGCGTTCACCGCGAATAATCTGCGAACCGTCCGGCGCGCCGACCAGCG
+CACGCAGCCAGATTTCGCCATCAATAAGCTCGGCGTAGCTACCAATTGGCACCTGACATC
+CGCCTTCGAGACGGGTATTCATGGCGCGTTCTGCGGTAACGCGCAGTGCAGTTTCGTGGT
+GATTCAGCGCGGCAAGCAGCTCGCGAGTGCGTGAATCATCAAGGCGGCATTCAATACCCA
+CCGCACCTTGTCCTACCGCCGGAAGAGAAATCTCGGGTGGCAACGCGGCGCGAATACGTG
+ACTCCAGACCTAAACGTTTTAGTCCGGCTACGGCAAGAATGATGGCATCGTATTCGCCGT
+TATCCAGTTTGCTCAGGCGAGTGCCGACGTTGCCGCGCAGGGAGCGGATAATCAGATCCG
+GACGGCGTTCAGCCAGTTGGCACTGGCGACGTAAACTGGACGTCCCGACGATACTGCCTG
+CCGGTAACGCATCCAGACTGTCATAGTTATTGGACACAAAGGCATCGCGAGGATCTTCAC
+GCTCACAAATAGTGACCAGTCCCAGACCTTGCGGGAATTCAACCGGCACATCTTTCATTG
+AGTGTACGGCGATATCGGCGCGATTTTCGAGGAGCGCGACTTCCAGCTCTTTTACAAATA
+AGCCTTTTCCGCCTACTTTCGCCAGCGGCGTATCAAGAATCACATCGCCGCGCGTCACCA
+TCGGTACCAGTTCAACGACCAGGCCCGGATGGCTCGCCATCAACTTGTCTTTGACATAGT
+GTGCCTGCCAGAGTGCAAGTGGGCTTTGGCGTGTGGCAATTCTTAAAACATTGTCTAACA
+TGCTTGTTACCGTCATTATCATCCGTGGTCCATCCTAACATCCTTGCCAGAGTGATGTCA
+GTGTTGTGGTGAAACGTAGACGCCTGCGCAAACCGTAAAATGAGGTCTGGCAGTGGATCC
+TGACAGGCGTTTCACGCCGTTGTAATAAGGAATTTACAGAGAATAAACGGTGCTACACTT
+GTATGTAGCGCATCTTTCTTTACGGTCAATCAGCAAGGTGTTAAATTGATCACGTTTTAG
+ACCATTTTTTCGTCGTGAAACTAAAAAAACCAGGCGCGAAAAGTGGTAACGGTTACCTTT
+GACATACGAAATATCCCGAATGCCGCGTGTTACCGTTGATGTTGGCGGAATCACAGTCAT
+GACGGGTAGCAAATCAGGCGATACGTCTTGTACCTCTATATTGAGACTCTGAAACAGAGA
+CTGGATGCCATAAATCAATTGCGTGTGGATCGCGCGCTTGCTGCTATGGGGCCTGCATTC
+CAACAGGTCTACAGTCTACTGCCGACATTGTTGCACTATCACCATCCGCTAATGCCGGGT
+TACCTTGATGGTAACGTTCCCAAAGGCATTTGCCTTTACACGCCTGATGAAACTCAACGC
+CACTACCTGAACGAGCTTGAACTGTATCGTGGAATGTCAGTACAGGATCCGCCGAAAGGT
+GAGCTTCCAATTACTGGTGTATACACCATGGGCAGCACCTCGTCCGTAGGGCAAAGTTGT
+TCCTCTGACCTGGATATCTGGGTCTGTCATCAATCCTGGCTCGATAGCGAAGAGCGCCAA
+TTGCTACAACGTAAATGTAGCCTGCTGGAAAACTGGGCCGCCTCGCTGGGTGTGGAAGTC
+AGCTTCTTCCTGATTGATGAAAACCGCTTCCGTCATAATGAAAGCGGCAGCCTGGGGGGC
+GAAGATTGTGGCTCCACCCAGCATATACTGCTGCTTGACGAATTTTATCGTACCGCCGTG
+CGTCTCGCCGGTAAGCGTATTCTGTGGAATATGGTGCCGTGCGACGAAGAAGAGCATTAC
+GACGACTATGTGATGACGCTTTACGCGCAGGGCGTGCTGACGCCAAATGAATGGCTGGAT
+CTCGGTGGCTTAAGCTCGCTTTCTGCTGAAGAGTACTTTGGTGCCAGCCTTTGGCAGCTC
+TACAAGAGTATCGATTCCCCATACAAAGCGGTACTGAAAACACTGCTGCTGGAAGCCTAT
+TCCTGGGAATACCCGAACCCACGTCTGCTGGCGAAAGATATCAAACAGCGTTTGCACGAC
+GGCGAGATTGTATCGTTTGGTCTCGATCCATACTGCATGATGCTGGAGCGTGTTACTGAA
+TACCTGACGGCGATTGAAGATTTTACCCGTCTGGATTTAGTACGTCGCTGCTTCTATTTA
+AAAGTGTGCGAAAAGCTCAGCCGTGAACGCGCCTGCGTAGGCTGGCGTCGCGCAGTGTTG
+AGCCAGTTAGTGAGCGAGTGGGGTTGGGACGAAGCTCGTCTGGCAATGCTCGATAACCGC
+GCTAACTGGAAGATTGATCAGGTGCGTGAGGCGCACAACGAGTTGCTCGACGCGATGATG
+CAGAGCTACCGTAATCTGATCCGCTTTGCGCGTCGCAATAACCTTAGCGTCTCCGCCAGT
+CCGCAGGATATCGGCGTGCTGACGCGTAAGCTGTATGCCGCGTTTGAAGCATTACCAGGT
+AAAGTGACGCTGGTAAACCCGCAGATTTCACCCGATCTCTCGGAACCGAATCTGACCTTT
+ATTTATGTGCCGCCGGGCCGGGCTAACCGTTCAGGTTGGTATCTGTATAACCGCGCGCCA
+AATATTGAGTCGATCATCAGCCATCAGCCGCTGGAATATAACCGTTACCTGAATAAACTG
+GTGGCGTGGGCATGGTTTAACGGCCTGCTGACCTCGCGCACCCGTTTGTATATTAAAGGT
+AACGGCATTGTCGATTTGCCTAAGTTGCAGGAGATGGTCGCCGACGTGTCGCACCATTTC
+CCGCTGCGCTTACCTGCACCGACACCGAAGGCGCTCTACAGCCCGTGTGAGATCCGCCAT
+CTGGCGATTATCGTTAACCTGGAATATGACCCGACAGCGGCGTTCCGCAATCAGGTGGTG
+CATTTCGATTTCCGTAAGCTGGATGTCTTCAGCTTTGGCGAGAATCAAAATTGCCTGGTA
+GGTAGCGTTGACCTGCTGTACCGCAACTCGTGGAACGAAGTGCGTACGCTGCACTTCAAC
+GGCGAGCAATCGATGATCGAAGCCCTGAAAACTATTCTCGGCAAAATGCATCAGGACGCC
+GCACCGCCAGATAGCGTGGAAGTCTTCTGTTATAGCCAGCATCTGCGCGGCTTAATTCGT
+ACTCGCGTGCAGCAACTGGTTTCTGAGTGTATTGAATTGCGTCTTTCCAGCACCCGCCAG
+GAAACCGGGCGTTTCAAGGCGCTGCGCGTTTCTGGTCAAACCTGGGGGTTGTTCTTCGAA
+CGCCTGAATGTATCGGTACAGAAACTGGAAAACGCCATCGAGTTTTATGGCGCGATTTCG
+CATAACAAACTGCACGGCCTGTCAGTGCAGGTTGAAACCAATCACGTCAAATTACCGGCG
+GTGGTGGACGGCTTTGCCAGCGAAGGGATCATCCAGTTCTTTTTCGAAGAAACGCAAGAC
+GAGAATGGCTTTAATATCTACATTCTCGACGAAAGCAACCGGGTTGAGGTATATCACCAC
+TGCGAAGGCAGCAAAGAGGAGCTGGTACGTGACGTCAGTCGCTTCTACTCGTCATCGCAT
+GACCGCTTTACCTACGGCTCAAGCTTCATCAACTTCAACCTGCCGCAGTTCTATCAGATT
+GTGAAGGTTGATGGTCGTGAACAGGTGATTCCGTTCCGCACAAAATCTATCGGTAACATG
+CCGCCTGCCAATCAGGATCACGATACGCCGCTATTACAGCAATATTTTTCGTGATGAACG
+TGCCGGAAAGCGAGGCTTATCCGGCATGCAATCTTAGCGGAAACTGACTGTTTCACCCGC
+CTGCTGCGTCGCCGCCTGTTCCAGCAAATCCCAGAAGGTTTCGCCGCTGCGATCACAAAT
+CCACTCATCGCCTTTCAGGTCAAAATGGTAGCCGCCCTGTTTGGTTGCCAGCCATACCTG
+GTGCAGCGGCTCCTGGCGGTTGATAATGATTTTGCTGCCATTCTCAAAGGTAATGGTCAG
+TACGCCGCCGTTGATTTCGCAGTCGATATCGCTGTCGCCATCCCAGTCGTCCAGGCGTTC
+TTCAATGGTCAGCCAGAGTTGATCAGCCAGGCGATGAAATTCACTGTCGTTCATTGTTGT
+ATCCTGTTTTTAAGTGATGGCGGCAGTATAGCGGCATGGGGTCAGGGCTTCAAAGTTTGC
+ACCTCTGCGGCTGCGTTCCGGCACGATTCATCCGTCACCGGAATAATGATGTCTCTGTGT
+AGCGAAAGATTTGTCTCTTCATTAGGGCGCAGTTACACCACGTCTTTCCCTGTTTCTGGT
+AAACATTATGATCAGGTTTACCGAGCGAGCATCCTCACGCTGACGGAACTAAAAAAGACA
+ACAAACAAACCACATTGCGATAGTGCATAAAGCCATCCTGGCGCGAGGTGCCGATCACGA
+AACTACCAGCAAAACATAAATCCCCACGAGTAAGCGTTATACTCGCAGCATTTCCTCACT
+TTTCAGACTTCATAAAGAGTCGCTAAACGCTTGCTTTTACGTCTTCTCCTGCGATGATAG
+AAAGCAGAAAGCGATGAACTTTACAGGCAATCCATAATGAAAAACGTGTTTAAGGCACTC
+ACTGTATTACTTACTCTCTTCAGCCTGACGGGCTGCGGTCTGAAAGGTCCGCTCTATTTC
+CCGCCTGCAGATAAAAACGCACCGCCGCCGACCAAACCGGTAGAGACGCAAACGCAATCC
+ACGGTGCCGGATAAAAACGATCGCGCCACTGGCGATGGTCCATCCCAGGTGAATTACTAA
+AAGTCAGTTTCTGTACCCGCGTGATTGGAGTAAATGATGCAGTTCTCGAAAATGCATGGC
+CTTGGCAACGATTTTATGGTCGTCGACGCGGTAACGCAGAATGTCTTTTTTTCACCGGAG
+CTGATTCGTCGCCTGGCTGATCGGCACCTGGGGGTAGGGTTTGACCAACTGCTGGTGGTT
+GAGCCGCCGTATGATCCTGAACTGGATTTTCACTATCGCATTTTCAATGCTGATGGCAGT
+GAAGTGGCGCAGTGCGGCAACGGTGCGCGCTGCTTTGCCCGTTTTGTGCGTCTGAAAGGA
+CTGACCAATAAGCGTGATATCCGCGTCAGCACCGCCAACGGGCGGATGGTTCTGACCGTC
+ACCGATGATGATCTGGTCCGCGTAAATATGGGCGAACCCAACTTCGAACCTTCCGCCGTG
+CCGTTTCGCGCTAACAAAGCGGAAAAGACCTATATTATGCGCGCCGCCGAGCAGACAATC
+TTATGCGGCGTGGTGTCGATGGGAAATCCGCATTGCGTGATTCAGGTCGATGATGTCGAT
+ACCGCGGCGGTAGAAACGCTTGGTCCTGTTCTGGAAAGCCACGAGCGTTTTCCGGAGCGC
+GCCAATATCGGTTTTATGCAAGTGGTTAAGCGCGAGCATATTCGTTTACGCGTTTATGAG
+CGTGGGGCAGGAGAAACCCAGGCCTGCGGCAGCGGCGCGTGTGCGGCGGTTGCAGTAGGG
+ATTCAGCAAGGTTTGCTGGCCGAAGAAGTACGCGTGGAACTCCCCGGCGGTCGTCTTGAT
+ATCGCCTGGAAAGGTCCGGGTCACCCGTTATATATGACTGGCCCGGCGGTACATGTCTAC
+GACGGATTTATTCATCTATGAAGCAACCAGGGGAAGAACTGCAGGAAACACTCACGGAGC
+TTGATGACCGGGCGGTTGTCGATTATCTGATTAAAAATCCTGAGTTTTTTATCCGTAATG
+CGCGCGCAGTAGAAGCGATACGTGTGCCGCATCCGGTACGCGGCACCGTTTCGTTGGTCG
+AGTGGCACATGGCCCGCGCACGTAATCATATTCATGTTCTGGAAGAGAACATGGCGCTGT
+TGATGGAACAGGCTATCGCCAACGAAGGCCTGTTTTATCGCCTACTCTACCTGCAGCGCA
+GTCTCACCGCCGCCAGCAGTCTCGACGATATGCTGATGCGCTTTCACCGCTGGGCGCGCG
+ATCTCGGCCTGGCAGGTGCGAGTCTGCGCCTGTTTCCGGATCGCTGGCGCTTAGGTGCGC
+CGTCGAACCACACTCATCTGGCATTAAGCCGTCAGTCTTTCGAACCGCTGCGTATTCAGC
+GTTAGGGGCAGGAACAGCACTATCTTGGGCCGCTTAACGGACCAGAGCTGCTGGTGGTGC
+TACCGGAAGCGAAAGCGGTGGGATCGGTGGCGATGTCGATGCTGGGAAGCGATGCTGATT
+TGGGTGTCGTGCTGTTTACCAGTCGCGATGCCAGTCACTATCAACAAGGGCAAGGAACGC
+AGTTACTTCATGAAATTGCGCTGATGTTGCCGGAGCTTCTGGAGCGTTGGATTGAACGCG
+TATGACCGATTTACACACCGATGTAGAACGCTACCTACGTTATCTGAGCGTGGAGCGCCA
+GCTTAGCCCGATAACCCTGCTTAACTACCAGCGTCAGCTTGAGGCGATCATCAATTTTGC
+CAGCGAAAACGGCCTGCAAAGCTGGCAGCAATGTGATGTGACGATGGTGCGCAATTTTGC
+TGTACGCAGTCGCCGTAAAGGGCTGGGAGCAGCAAGTCTGGCGTTACGGCTTTCTGCGCT
+ACGTAGCTTTTTTGACTGGCTGGTCAGCCAGAACGAACTCAAAGCTAACCCGGCGAAAGG
+TGTTTCGGCACCGAAAGCGCCGCGTCATCTGCCGAAAAACATCGACGTCGACGATATGAA
+TCGGCTGCTGGATATTGATATCAATGATCCCCTCGCTGTACGCGACCGTGCAATGCTGGA
+AGTGATGTACGGCGCGGGTCTGCGTCTTTCTGAGCTGGTGGGGCTGGATATTAAACACCT
+CGACCTGGAGTCTGGTGAAGTGTGGGTTATGGGGAAAGGCAGCAAAGAGCGCCGCCTGCC
+GATTGGTCGCAACGCTGTGGCGTGGATTGAGCACTGGCTTGATTTGCGCGACCTGTTTGG
+TAGCGAAGACGACGCGCTTTTTCTGTCGAAACTGGGCAAGCGTATCTCCGCGCGTAATGT
+GCAGAAACGCTTTGCCGAATGGGGCATAAAACAAGGGCTGAATAATCACGTTCATCCGCA
+TAAATTACGTCACTCGTTCGCCACGCATATGCTGGAGTCGAGCGGCGATCTTCGTGGTGT
+GCAGGAGCTGCTGGGTCATGCCAACCTCTCCACCACGCAAATCTATACTCATCTTGATTT
+TCAACACCTTGCCTCGGTGTACGATGCGGCGCATCCACGCGCCAAACGGGGGAAATAATG
+CGTTTTTACCGGCCTTTGGGGCGCATCTCGGCGCTCACCTTTGACCTGGATGATACCCTT
+TACGATAACCGTCCGGTGATTTTGCGCACCGAGCGAGAGGCGCTTACCTTTGTGCAAAAT
+TATCATCCGGCGCTGCGCAGCTTCCAGAATGAAGATCTGCAACGCCTGCGCCAGGCGGTA
+CGGGAAGCGGAACCCGAGATTTATCACGACGTGACGCGCTGGCGTTTTCGTTCGATTGAA
+CAAGCGATGCTCGACGCCGGGCTGAGTGCCGAAGAAGCCAGTGCAGGCGCACACGCAGCA
+ATGATCAACTTTGCCAAATGGCGCAGCCGAATCGACGTCCCGCAGCAAACTCACGACACC
+TTAAAACAGCTGGCGAAGAAATGGCCGCTGGTGGCGATCACCAACGGTAACGCCCAGCCG
+GAGCTGTTTGGTTTGGGGGATTATTTTGAGTTTGTGCTGCGCGCTGGCCCGCACGGGCGC
+TCAAAACCGTTCAGCGATATGTACTTTTTGGCTGCGGAAAAACTCAACGTGCCGATCGGC
+GAGATCTTACATGTTGGGGACGATCTCACCACTGACGTGGGTGGGGCAATTCGCAGCGGA
+ATGCAGGCTTGTTGGATCAGACCGGAAAATGGCGATCTGATGCAAACCTGGGACAGCCGT
+TTACTGCCGCATCTGGAAATTTCCCGGTTGGCATCTCTGACCTCGCTGATATAATCAGCA
+AATCTGTATATATACCCAGCTTTTTGGCGGAGGGCGTTGCGCTTCTCCGCCCAACCTATT
+TTTACGCGGCGGTGCCAATGGACGTTTCTTACCTGCTCGACAGCCTTAATGACAAACAGC
+GCGAAGCGGTGGCCGCGCCACGCAGCAACCTTCTGGTGCTGGCGGGCGCGGGCAGTGGTA
+AGACGCGCGTACTGGTGCATCGTATCGCCTGGTTGATGAGCGTGGAAAACTGCTCGCCAT
+ACTCGATTATGGCGGTGACGTTTACCAACAAAGCGGCGGCGGAGATGCGTCATCGTATCG
+GGCAACTGATGGGCACGAGCCAGGGCGGTATGTGGGTCGGCACCTTCCACGGGCTGGCGC
+ACCGTTTGCTGCGTGCGCACCATATGGACGCCAATCTGCCGCAGGATTTCCAGATCCTCG
+ACAGTGAAGACCAGCTACGCCTGCTTAAGCGTCTGATCAAAGCCATGAACCTCGACGAGA
+AGCAGTGGCCGCCGCGGCAGGCAATGTGGTACATCAACAGCCAGAAAGATGAAGGCCTGC
+GTCCGCATCATATTCAAAGCTACGGTAATCCGGTGGAGCAGACCTGGCAGAAGGTGTATC
+AGGCGTATCAGGAAGCGTGTGACCGCGCGGGCCTGGTGGACTTCGCCGAGCTGCTGCTGC
+GCGCTCACGAGTTGTGGCTTAACAAGCCGCATATCCTGCAACACTACCGCGAACGTTTTA
+CCAATATCCTGGTGGACGAATTCCAGGATACCAACAACATTCAGTACGCGTGGATCCGCC
+TGCTGGCGGGCGACACCGGCAAAGTGATGATCGTCGGTGATGACGACCAGTCAATCTACG
+GCTGGCGCGGGGCGCAGGTGGAGAATATTCAGCGTTTCCTTAATGATTTCCCCGGTGCCG
+AAACTATTCGTCTGGAGCAAAACTACCGCTCTACCAGCAATATTCTGAGCGCCGCTAACG
+CCCTGATTGAAAACAATAACGGGCGTCTGGGTAAAAAACTGTGGACCGATGGCGCGGACG
+GTGAGCCTATTTCCCTCTATTGCGCTTTTAACGAACTCGATGAAGCGCGTTTTGTGGTTA
+ACCGCATCAAAACCTGGCAGGACAACGGCGGAGCGCTTGCCGAGTGCGCCATTCTCTACC
+GCAGCAACGCCCAGTCGCGGGTGCTCGAAGAGGCGTTATTGCAGGCCAGTATGCCGTACC
+GTATTTACGGCGGGATGCGCTTCTTCGAACGCCAGGAAATCAAAGATGCGCTCTCGTATC
+TGCGCCTGATTGCCAACCGCAACGACGACGCGGCCTTTGAGCGTGTGGTGAATACGCCAA
+CGCGGGGTATTGGTGACCGGACGCTGGACGTGGTACGTCAGACATCGCGCGATCGCCAGT
+TAACACTCTGGCAGGCATGTCGTGAGCTGTTGCAGGAAAAAGCCCTCGCCGGGCGAGCTG
+CCAGCGCCTTGCAGCGATTTATGGAATTAATCGACGCCTTAGCGCAGGAAACTGCCGATA
+TGCCGCTGCATGTACAGACTGACCGGGTAATTAAAGACTCCGGCCTGCGTACCATGTATG
+AGCAGGAGAAGGGCGAAAAAGGTCAGACGCGTATCGAAAACTTAGAGGAACTGGTGACGG
+CAACGCGCCAGTTCAGCTACAACGAAGAAGACGAAGATTTAATGCCGCTGCAGGCGTTCC
+TCTCCCATGCGGCACTGGAAGCAGGTGAAGGGCAGGCGGATACCTGGCAGGATGCGGTGC
+AGTTGATGACGCTACACTCGGCGAAAGGCCTGGAGTTCCCGCAGGTGTTTATCGTTGGTA
+TGGAAGAGGGCATGTTCCCAAGCCAGATGTCGCTGGATGAAGGCGGGCGTCTGGAAGAAG
+AACGCCGTCTGGCCTACGTTGGCGTAACCCGCGCGATGCAGAAACTGACGCTGACCTACG
+CGGAAACCCGCCGTCTGTATGGTAAAGAGGTTTACCATCGCCCGTCGCGCTTTATCGGCG
+AGCTGCCGGAAGAGTGTGTGGAAGAGGTGCGCCTGCGCGCCACGGTAAGCCGCCCGGTCA
+GCCATCAGCGGATGGGTACGCCGATGGTCGAGAACGACAGCGGCTACAAGCTCGGCCAGC
+GCGTACGCCACGCTAAGTTTGGTGAAGGCACCATTGTCAATATGGAAGGCAGCGGTGAGC
+ATAGCCGTTTGCAGGTGGCATTTCAGGGCCAGGGTATTAAATGGCTGGTGGCGGCATACG
+CCCGGCTGGAGTCGGTGTAACGTTGCCGGATGCGGTGCTGCGCACCTTATTTGGCCTAAA
+AAATCATTCAGATTCAATAAATTGCAACGTCATGTAGGCCGGATAGGGCGTTTACGCCGC
+ATCCGGCATCTGCGCCATCTTCAGTATCTGACACAAAACTATCGTTTTAACCTTTCCGCT
+CGACGGAAATCATGGTGACAAAAGGATAGCGTTGCCACGGGATTGCCCCGCCTTTCATAT
+ACATATGTGAAATCGTGCCATCAAGATAAAGCAGCTGCTCAACGTTCAGTTTCGCTTTGG
+CATAACAGGCAAAATCATAAAAATTTGTTGCCTGCTGGCTCAACAAAAACACGGCGTTCC
+CATGTTTATTAATCCCAACACCGTTACGAATTTTGCTTGAGGCGACGTTGGGATGAATAC
+GCGGATTAATTACACCGTTTTCCATCAACATTGGCCCTGACTGCACCGCAAACTGAATCT
+CTTTACTGGTTTTGAAGGCATCCAGACGAACGATGCCGACTTTATCTCCCGCGACATAAA
+ACACGCCGCCAGGACGGATAAAGAAATTCCCTTCACCTGAAGCGAGATTTAACGCCACCT
+TCTGCTGACCGTTTTCGATGTACAAACCGAGCGGCGCATAGCTTTCATCATAGATGCCGC
+CGTTCATCGCCATCTGCACCTGACCCTGACTATTAATATCCGCCAGCAGAGCATGTAACG
+TTCCCCACGCTTCGCCATTGGCTTTTTGCCAGTACATTTTCACCCGCTCTGTTTGAGGAT
+TAACGGTATACGCCTGTACGGTCAGCGTCGGATCTGAGAGTGCGCAATCATCAGCGGCAA
+CAGCAAACAAGGGAAGTAAGGTGAGGGCGAGAAAAATCCGTTTGAGATTCAAGGTGATCA
+TTCCTTTACCAATGAGTAGCTGATGCGCCATTATAGGTCCTGGATGTGGGATTTTTTTAT
+CCTGTTAGCGACCTTGACGAGTACCAAAAAGCGCGAAGTTCAACTATTGTTCTGTGGTGT
+TCTGTTGCGTGTTGACGGCAAAATTTTGCTGGCGTAACATGCGCGCACGATCACTCTAAG
+AGGACATTCGCCTTGGACACACCCAGTAGATACTGGCTCACTATCCTGTCATCCAGGATC
+AACTCCTAAGGCTATCCCTTTTTGCTGATAGCCTTAGCGGTTGTCAGCGACCTCAATTTT
+TCCCGTCGCGCTGAGTCAGGCTGTTTAATGGTCTGAAACCCAATTTGTTTCTGTGTGCCC
+ACCGAACTGTCCGATATTTTAAGCATTGGGAGTCCCGGTCATGCTGAGCGCATTTCAACT
+GGAAAATAACCGACTGACCCGGCTGGAAGTCGAAGAGTCACAACCCCTTGTAAATGCAGT
+ATGGATTGATCTTGTCGAACCGGACGACGACGAGCGACTGCGCGTACAATCTGAACTTGG
+CCAGAGCCTGGCAACCCGCCCGGAACTGGAAGACATCGAAGCATCGGCACGTTTCTTTGA
+AGACGACGACGGCCTGCATATTCACTCCTTCTTCTTCTTTGAAGATGCGGAAGATCACGC
+CGGTAACTCCACTGTGGCATTTACCATCCGTGATGGTCGTCTGTTTACTCTGCGTGAGCG
+TGAACTGCCCGCTTTTCGTCTGTATCGTATGCGTGCCCGTAGCCAGTCGATGGTAGACGG
+TAACGCCTACGAGTTGCTGCTGGATCTGTTCGAAACCAAAATCGAACAGTTGGCAGATGA
+AATTGAAAATATCTATAGCGACCTGGAGCAGTTGAGCCGGGTGATTATGGAAGGGCATCA
+GGGCGATGAGTACGACGAGGCGCTCTCCACTCTGGCGGAACTGGAAGATATCGGCTGGAA
+AGTTCGCCTGTGTCTGATGGATACCCAGCGCGCGCTCAACTTCCTGGTGCGTAAAGCGCG
+TTTACCGGGTGGGCAACTGGAGCAGGCGCGTGAAATCCTGCGAGATATCGAATCCCTGCT
+GCCGCATAACGAATCCCTGTTCCAGAAGGTGAACTTCCTGATGCAGGCGGCAATGGGTTT
+TATCAACATCGAGCAGAACCGCATCATCAAAATCTTCTCGGTGGTATCCGTGGTATTCCT
+GCCGCCGACGCTCGTTGCTTCCAGCTATGGCATGAACTTTGAGTTTATGCCAGAACTGAA
+GTGGAGCTTCGGCTACCCTGGCGCGATTATCTTTATGATCCTCGCGGGCCTGGCACCGTA
+TCTGTACTTTAAGCGGAAGAACTGGTTGTAAAAAACGAGAGCGGTGGCTTAGTCTGGCTA
+AGCCACCTGTTATTCAAAGGCTCCAGGTATTTAACCCTTTTACCTCTTTCTCATAGAACC
+ATTTGTTCGTGTTAACAGCAACATAGGCTGCTACGGCAATTCCCAGAATGTTAACGCCAA
+TTAGTGCACCAACAAATAGAGATAGAATACCAAGTAATAGAACTATAATTGCTTTTTTCC
+ATAACCCCAGGACAAATAAATATATCCAGGAACAGAAGAAAGCAATGAAATTCATTTGAA
+TAGTTAAGCGTTGTCTTACTTTTAATGCTTTAAATGCTGCTTTATATTCTGGTGTTGCCC
+CCCAGAATCCAGGAAAACCATGTTGATCATAAAAATTAAATCGGTATTTCCATTTTTCAC
+TTAATGAACCATCGTTCATATATTCCTTACTCATAAATACTCCATAACTATTGTTTTGAT
+GAATCAGTAGGTGCAAGCATTAGCATACTGAAAGTGGAAAAATAACAAATCAAAAAAATC
+ATCGAACCATTGCCTGAACAGGCAAAATCTTCGGCTATCATTGTGATGATAGAGATGATA
+TATACTGCTAATGTACCAAAAACATAAGTTTTTATATAGATGAAACCACTATCACGGAGT
+CGCTGGCAATTCATGTTGATGACGAGATAATGGAGTACGATGGTAGAGACTATAACAAGA
+AAGCCTGCTTCTCCATCGTTAAAAAAGATAATAAGAAAGGCAAAAATGAAATTTATTAAA
+ATAAATGAAAATATATAACGACGTCTGGAAATCTTACCGTTAGATGTTGGGATAAATATA
+CGTAACATAAATTTTACATCCTTGTATGAGTCTCCGGTCAGCATGGCAATATGCCCACTC
+TCATGCAAGAGTCGGCATATTTTTTCAGAATATATTTATTTTTTATTTGGACGTTCTACG
+CTGCGTATAAATCGCATCCATCACAAAAATTGCCAGCGCCACCCAAATAAAGGCGAAAGT
+CACCATCTTATCGGCACCCGGTTTTTCACCATAAAACGTCACAGCCAGCAGGAACATCAG
+CGTCGGGCCAATGTACTGGAAAAAGCCTAACGTTGAGAGACGCAAGCGCGTGGCAGCGGC
+GGTAAAACACAACAGCGGTACGGTAGTGACAATACCGGCGGCGATCAGCAGTAAATTCAG
+CGACATCGGGTTTTGCCCCATATGGCTGGTTGAGCTGTCGGCAATAGCAAACAGGTAAAT
+TGCCGCCACGGGCAGCAGCCACATGGTTTCGATTAACATGCCGGTTTGCGCTTCAACGGC
+AATCTTCTTGCGTACCAGACCGTAGAAGGCAAAACTAAATGCCAGTCCCAGCGCGATAAT
+AGGTAGCGAACCAAAAGTCCACAGCTGGACTAACACGCCACATATCGCCAGAATCACCGC
+CAGCCATTGCATCCGGCGGAATCGCTCGCCGAGGAAAATCATCCCCAGCACAATGTTCAC
+CAGCGGGTTAATAAAGTAACCAAGGCTCGCTTCCAGCATATGGTGATTGTTCACCGCCCA
+GATAAACAGTAGCCAGTTGCCACCAATCAGCACGGCAGAGACTGCCAGCATAAAAATTTT
+CTGTGGCGTCTGAATCAGCGTTTTTAAATAGGACCACTGGCGGCAAATGCTCATCAGCAC
+CACCATAAAGAAAAACGACCAGATCACGCGATGCGTCAGGATTTCATCGGCGGGCACGTA
+GTAAATCAACTTGAAGTACGCTGGCGCTATACCCCAAATAAAATAAGCGGCAAGAGCGAG
+TAATACGCCCTGCCGCGTTTGTTTTGCATCCATCGGGAATACTCATTTTTAATTGGTAAC
+AGCAGTTTACCTGCTTTTATGTCTTCAACCTACCATATAGGTGGCGGTGGCACTGGCAAT
+ATAAAGCTGTTCTTCATTGTGTAATTCAACGCGGGCGACGGCGACTTTATTGCCTGCACG
+CAACAGGCTACTAGTAGCAGTAAAACGCTCGCCCCTGCCTGGGCGCAGATAATCAACGCG
+AAGATCAATGGTCCCCATCCGCGATAGCCGCTGGCGTAGTTCATCTTCACTGATGGTTTC
+GTGGCGGGTTAAGGTACTTCCCACGCACACCAGACCGGCGGCGACATCCAGCGCCGACGC
+AATGACCCCGCCGTGCAAAATGCTTTGCGCCCAGTTGCCCACCATCATTGGCTGATTTTT
+AAAGGCCAGCTGTGCGAACTCTTTTTCGTAACGCTCCAGTTCCATCCCCAATGCGCGGTT
+AAATGGCATGTGATAAACAAACATCTCACCCACTAATTTCAGGGCTTGTTCAGCGGTCAG
+TACGGCAGACATATCATCCTTACACTTCATTGGTTAATGAAATGTTGATTTTATGCTTCT
+TTGTTGTTGGTTTCTACTTTAGGAAGGGATAACTAACGGCTATGGAGTTAAGTATGTAAA
+ATAGCCCGCAGAAAAATATTCACCTTATCAATAATTCGTTACGGAGAACACGACCGATGC
+GGACTCTGCAGGGCTGGTTGTTGCCGGTGTTTATGTTGCCTATGGCAGTATATGCACAAG
+AGGCAACGGTGAAAGAGGTGCATGACGCGCCAGCGGTGCGTGGCAGTATTATCGCCAATA
+TGCTGCAGGAGCATGACAATCCGTTCACGCTCTATCCTTATGACACCAACTACCTCATTT
+ACACCCAAACCAGCGATCTGAATAAAGAAGCGATTGCCAGTTACGACTGGGCGGAAAATG
+CGCGTAAGGATGAAGTAAAGTTTCAGTTGAGCCTGGCATTTCCGCTGTGGCGTGGGATTT
+TAGGCCCGAACTCGGTGTTGGGTGCGTCTTATACGCAAAAATCCTGGTGGCAACTGTCCA
+ATAGCGAAGAGTCTTCACCGTTTCGTGAAACCAACTACGAACCGCAATTGTTCCTCGGTT
+TTGCCACCGATTACCGTTTTGCAGGTTGGACGCTGCGCGATGTGGAGATGGGGTATAACC
+ACGACTCTAACGGGCGTTCCGACCCGACCTCCCGCAGCTGGAACCGCCTTTATACTCGCC
+TGATGGCAGAAAACGGTAACTGGCTGGTAGAAGTGAAGCCGTGGTATGTGGTGGGTAATA
+CTGACGATAACCCGGATATCACCAAATATATGGGTTACTACCAGCTTAAAATCGGCTATC
+ACCTCGGTGATGCGGTGCTCAGTGCGAAAGGACAGTACAACTGGAACACCGGCTACGGCG
+GCGCGGAGTTAGGCTTAAGTTACCCGATCACCAAACATGTGCGCCTTTATACTCAGGTTT
+ACAGCGGCTATGGCGAATCGCTCATCGACTATAACTTCAACCAGACCCGTGTCGGTGTGG
+GGGTTATGCTAAACGATTTGTTTTGATGAACGGTTGAGTGGTTGGCAAATCTGGAATCCA
+GCATCCAGGATTACCCTCTCAGAGACTAAAAGCATTGCAGTTTCTCGCGCAGGCGCTGAA
+AATAGCGCCTGTTTTTATTTCAGGCAATCGGGGTGAATGTGGCGCAGGCGGAAGTGTTGA
+ATCTGGAGTCCGGAGCTAAACAGGTTTTACAAGAAACCTTTGGCTACCAACAGTTTCGCC
+CCGGCCAGGAAGAAATTATCGACACTGTGCTTTCCGGCCGCGATTGCCTCGTCGTCATGC
+CCACTGGTGGCGGAAAATCCCTTTGCTATCAAATCCCTGCCTTATTGCTAAACGGCCTTA
+CCGTGGTTGTTTCACCGCTGATTTCGTTGATGAAAGATCAGGTGGATCAACTGCAAGCCA
+ACGGCGTGGCGGCGGCGTGCCTTAACTCGACGCAAACCCGCGAACAGCAACTTGAAGTGA
+TGACAGGCTGCCGCACCGGGCAAATTCGTCTGCTTTATATCGCCCCGGAACGCCTGATGC
+TGGATAACTTTCTTGAGCATCTGGCGCACTGGAATCCGGTGTTATTAGCCGTTGATGAAG
+CGCACTGTATCTCCCAATGGGGCCACGATTTCCGCCCGGAATATGCCGCGCTCGGTCAGT
+TGCGCCAGCGGTTCCCGACGCTGCCGTTTATGGCGCTGACCGCCACAGCCGACGACACCA
+CGCGCCAGGATATCGTGCGCCTGCTGGGGCTGAACGATCCGCTGATTCAAATCAGCAGTT
+TTGACCGTCCGAATATTCGCTACATGCTGATGGAGAAGTTCAAACCGCTCGATCAGTTGA
+TGCGCTACGTGCAGGAACAGCGCGGTAAGTCAGGCATTATCTACTGCAACAGCCGCGCGA
+AAGTAGAAGACACCGCTGCGCGCCTGCAAAGCAAGGGAATTAGCGCGGCGGCCTATCATG
+CCGGGCTGGAAAATAATGTTCGCGCCGATGTGCAGGAAAAATTCCAGCGCGATGACCTGC
+AAATTGTGGTGGCGACGGTGGCGTTCGGCATGGGCATCAATAAACCAAACGTTCGCTTCG
+TGGTCCACTTTGATATTCCGCGCAATATCGAATCCTATTATCAGGAAACCGGACGCGCCG
+GGCGTGATGGCCTGCCCGCGGAAGCGATGCTGTTTTACGATCCGGCTGATATGGCGTGGC
+TGCGCCGTTGTCTGGAAGAGAAGCCGCAGGGGCAGTTGCAGGATATCGAGCGCCACAAAC
+TCAATGCGATGGGCGCGTTTGCCGAAGCGCAAACTTGCCGTCGTCTGGTATTGCTGAACT
+ATTTTGGCGAAGGGCGTCAGGAGCCGTGCGGGAACTGCGATATCTGCCTCGATCCGCCGA
+AACAGTACGACGGTTCAACCGATGCTCAGATTGCCCTTTCCACCATTGGTCGTGTGAATC
+AGCGGTTTGGGATGGGTTATGTGGTGGAAGTGATTCGTGGTGCTAATAACCAGCGTATCC
+GCGACTATGGTCATGACAAACTGAAAGTCTATGGCATGGGCCGTGATAAAAGCCATGAAC
+ATTGGGTGAGCGTGATCCGCCAGCTGATTCACCTCGGCCTGGTGACGCAAAATATTGCCC
+AGCATTCTGCCCTACAACTGACAGAGGCCGCGCGCCCGGTGCTGCGCGGCGAATCCTCTT
+TGCAACTTGCCGTGCCGCGTATCGTGGCGCTCAAACCGAAAGCGATGCAGAAATCGTTCG
+GCGGCAACTATGATCGCAAACTGTTCGCCAAATTACGCAAACTGCGTAAATCGATAGCCG
+ATGAAAGTAATGTCCCGCCGTACGTGGTGTTTAACGACGCAACCTTGATTGAGATGGCTG
+AACAGATGCCGATCACCGCCAGCGAAATGCTCAGCGTTAACGGCGTTGGGATGCGCAAGC
+TGGAACGCTTTGGCAAACCGTTTATGGCGCTGATTCGTGCGCATGTTGATGGCGATGACG
+AAGAGTAGTCAGCAGCATAAAAAAGTGCCAGTATGAAGACTCCGTAAACGTTTCCCCCGC
+GAGTCAAATGTATGTTGATGTTATTTCTCACCGTCGCCATGGTGCACATTGTGGCGCTTA
+TGAGCCCCGGTCCCGATTTCTTTTTTGTCTCTCAGACCGCTGTCAGTCGTTCCCGTAAAG
+AAGCGATGATGGGCGTGCTGGGCATTACCTGCGGCGTAATGGTTTGGGCTGGGATTGCGC
+TGCTTGGCCTGCATTTGATTATCGAAAAAATGGCCTGGCTGCATACGCTGATTATGGTGG
+GCGGTGGCCTGTATCTCTGCTGGATGGGTTACCAGATGCTACGTGGTGCACTGAAAAAAG
+AGGCGGTTTCTGCACCTGCGCCACAGGTCGAGCTGGCGAAAAGTGGGCGCAGTTTCCTGA
+AAGGTTTACTGACCAATCTCGCTAATCCGAAAGCGATTATCTACTTTGGCTCGGTGTTCT
+CATTGTTTGTCGGTGATAACGTTGGCACTACCGCGCGCTGGGGCATTTTTGCGCTGATCA
+TTGTCGAAACGCTGGCGTGGTTTACCGTCGTTGCCAGCCTGTTTGCCCTGCCGCAAATGC
+GCCGTGGTTATCAACGTCTGGCGAAGTGGATTGATGGTTTTGCCGGGGCGTTATTTGCCG
+GATTTGGCATTCATTTGATTATTTCGCGGTGATGCCAGACGCGTCTTCAGAGTAAGTCGG
+ATAAGGCGTTTACGCCGCATCCGACATTATTTTTCACGCATGCCTCGCCGATGCTAACAG
+CGCTCCCACCAGCATAAACAACGAGCCGAAAATCTTATTCAGCGCCTTCATCTGCTTTGG
+TCCTTTAATCCATAGAGCAATCCGTTGAGCAAGGGTGGCGTAACCGATCATCACAATAAT
+ATCGACCACAATAGTGGTGACGCCGAGCACGATATACTGCATCAGTTGCGGCTGTTGCGG
+CATGATGAATTGCGGAAATAGCGCCGCCAGAAACACAATACTTTTGGGATTGGTGAGATT
+CACAAAAACTGCGCGCTGGAACAAATGTCGACGCGATTGAGTAGAGGCCAGCGATTTAAG
+GTCAATTGCACCAGCGGCGCGCCACTGCTGGATTCCCAGCCAAATCAAGTAAGCCGCGCC
+TGCCCACTTCAACACTTCAAACGCAATCACTGAGCGGGAAAATAGCGTCCCCAACCCCAC
+GCCAACCAGCACAATATGAATCGCCAGTCCGGTCTGAAGCCCAGCAATAGACGCCACCGC
+GCCGCGATAACCGTGGTTGAGCGAGGTGGTCATAGTGTTGATTGCACCAGAGCCTGGCGA
+CAGGCTTAAAATGATCGATGTCAGCAGGTAGGCAAACCACCATTCTAAGGTCATGATGAA
+CTCCCGGTGTGTCTATTTTTGTGCCACAATACGCTACTGTCGCAGCGTTGTGTCAGGCAC
+GCTAAAAAAAACGATTTTACGTGGTTTAAGAGGCAGATTACCCGATGTTTCAGCAGCAAA
+AAGACTGGGAAACAAGAGAAAACGCGTTTGCTGCTTTTACCATGGGACCGCTGACTGATT
+TCTGGCGTCAGCGTGATGAAGCAGAGTTTACTGGTGTGGATGACATTCCGGTGCGCTTTG
+TCCGTTTTCGCGCACAGCACCATGACCGGGTGGTAGTCATCTGCCCGGGGCGTATTGAGA
+GCTACGTAAAATATGCGGAACTGGCCTATGACCTGTTCCATTTGGGGTTTGATGTCTTAA
+TCATCGACCATCGCGGGCAGGGACGTTCCGGTCGCCTGTTAGCCGATCCGCATCTCGGGC
+ATGTTAATCGCTTTAATGATTATGTTGATGATCTGGCGGCATTCTGGCAGCAGGAGGTTC
+AGCCCGGTCCGTGGCGTAAACGCTATATACTGGCACATTCGATGGGCGGTGCGATCTCCA
+CATTATTTCTGCAACGCCATCCAGGTGTATGTGACGCCATTGCGCTAACTGCGCCAATGT
+TTGGGATCGTGATTCGTATGCCGTCATTTATGGCACGGCAGATCCTCAACTGGGCCGAAG
+CGCATCCACGTTTCCGTGATGGCTATGCAATAGGCACCGGGCGCTGGCGCGCGTTGCCGT
+TTGCTATCAACGTACTGACCCACAGCAGACAGCGATATCGACGTAACTTACGCTTCTATG
+CTGATGACCCAACGATTCGCGTCGGTGGGCCGACCTACCATTGGGTACGCGAAAGTATTC
+TGGCTGGCGAACAGGTGTTAGCCGGTGCGGGTGATGACGCCACGCCAACGCTTCTCTTGC
+AGGCTGAAGAGGAACGCGTGGTGGATAACCGCATGCATGACCGTTTTTGTGAACTCCGCA
+CCGCCGCGGGCCATCCTGTCGAAGGAGGACGGCCGTTGGTAATTAAAGGTGCTTACCATG
+AGATCCTTTTTGAAAAGGACGCAATGCGCTCAGTCGCGCTCCACGCCATCGTTGATTTTT
+TCAACAGGCATAACTCACCCAGCGGAAACCGCTCTACAGAGGTTTAAATTTCTTATGTAC
+CAGGTTGTTGCGTCTGATTTAGATGGCACGTTACTTTCTCCCGACCATACGTTATCCCCT
+TACGCCAAAGAAACTCTGAAGCTGCTCACCGCGCGCGGCATCAACTTTGTGTTTGCGACC
+GGTCGTCACCACGTTGATGTGGGGCAAATTCGCGATAATCTGGAGATTAAGTCTTACATG
+ATTACCTCCAATGGTGCGCGCGTTCACGATCTGGATGGTAATCTGATTTTTGCTCATAAC
+CTGGATCGCGACATTGCCAGCGATCTGTTTGGCGTAGTCAACGACAATCCGGACATCATT
+ACTAACGTTTATCGCGACGACGAATGGTTTATGAATCGCCATCGCCCGGAAGAGATGCGC
+TTTTTTAAAGAAGCGGTGTTCCAATATGCGCTGTATGAGCCTGGATTACTGGAGCCGGAA
+GGCGTCAGCAAAGTGTTCTTCACCTGCGATTCCCATGAACAACTGCTGCCGCTGGAGCAG
+GCGATTAACGCTCGTTGGGGCGATCGCGTCAACGTCAGTTTCTCTACCTTAACCTGTCTG
+GAAGTGATGGCGGGCGGCGTTTCAAAAGGCCATGCGCTGGAAGCGGTGGCGAAGAAACTG
+GGCTACAGCCTGAAGGATTGTATTGCGTTTGGTGACGGGATGAACGACGCCGAAATGCTG
+TCGATGGCGGGGAAAGGCTGCATTATGGGCAGTGCGCACCAGCGTCTGAAAGACCTTCAT
+CCCGAGCTGGAAGTGATTGGTACTAATGCCGACGACGCGGTGCCGCATTATCTGCGTAAA
+CTCTATTTATCGTAATCGTTCTTTATTTGGTCAGTTGTCAACCTGATACTTCGCTACAAT
+GGATACCCGTTAATCAAAGAGTTTTCCATTGTGGCGCTACTTATCATCACCACGATTCTG
+TGGGCCTTCTCCTTTAGCTTTTATGGCGAGTACCTTGCGGGGCACGTCGATAGCTATTTT
+GCGGTGCTGGTGCGCGTTGGCCTGGCGGCACTCGTTTTTCTGCCGTTTCTGCGTACCCGT
+GGCAATAGCCTGAAAACGGTCGGCCTGTATATGCTGGTGGGCGCGATGCAGCTTGGCGTG
+ATGTATATGCTGAGTTTCCGCGCTTATCTCTACCTGACGGTTTCCGAGCTGCTGCTGTTC
+ACCGTGCTGACGCCGCTCTACATCACGCTGATTTATGACATCATGAGTAAGCGCCGTCTG
+CGCTGGGGCTATGCCTTTAGCGCCTTGCTGGCGGTGATTGGTGCCGGGATTATTCGCTAT
+GATCAGGTCACCGACCATTTCTGGACTGGCTTGCTGCTGGTGCAACTCTCCAATATCACT
+TTTGCCATTGGCATGGTGGGTTACAAACGCCTGATGGAAACTCGCCCGATGCCACAGCAT
+AACGCCTTTGCGTGGTTCTATCTTGGCGCGTTTCTGGTGGCAGTGATTGCATGGTTCTTG
+CTGGGAAATGCGCAGAAAATGCCGCAAACCACGCTGCAATGGGGCATTCTGGTGTTTCTT
+GGCGTGGTGGCTTCCGGGATTGGCTACTTTATGTGGAACTACGGCGCGACGCAGGTGGAC
+GCCGGAACGCTGGGCATTATGAATAATATGCACGTTTCGGCAGGGCTGCTGGTAAACCTG
+GCTATCTGGCACCAACAGCCGCACTGGCCAACGTTTATTACAGGCGCGCTGGTGATCCTG
+GCCTCACTGTGGGTGCATCGTAAGTGGGTCGCTCCGCGCTCTTCACAAACGGCAGATGAT
+CGCAGGCGTGATTGCGCGCTGAGCGAATAAACGCTTCCGTAACTGGCTGACGCTGCTCGC
+CATCGCGCACGGCGGCGTACAGTCGGCTCCACAAGCCTTCGCCCAGGGTTTTGGTCACCA
+CCAGACCCTGGCGCTCAAAACTCTCTACTACCCAATGCGGTAGCGCGGCAATACCCATCC
+GCGCGGCAACCATCTGAATCAACAATAAGGTGTTATCGACGCTTTTCAGTGACGGGCTGA
+CGCCTGCCGGCTGAAGAAAATGCCGCCAGACATCCAGTCGACTACGCTGCACCGGATAAA
+TTAATAGCGTCTCGCTGGCGAGATCTTCCGGTGTAATTCGCGTTTTCGCCGCCAGTGGAT
+GGTCAGGTGCTAACACCAGACGCACTTCATAGTCGAACATCGGCGAATAATGCAGGCCAC
+TGCGCGGCAGAATATCGGACGTCATTACCAGATCCAGCTCTCCCTGTTGCAAGGCGGGCT
+GCGGGTCAAATGTCACGCCCGATTTAAAATCCATCTCTACCTGCGGCCAGTTCTTATGGA
+AATTTTCTAACGCGGGTGTCAGCCACTGAATACAGCTATGGCACTCAATGGCAATGCGCA
+GACGCGTCTGCTGCGGTTCATTGCAGGCTTGCAGGGCCTGGCTAATTTGCGGCAGTACCT
+GGTTTGCCAGTTGCAACAGGATTTCTCCCTGCGGTGTAAAGCGTAGCGGCTGGCTCTTAC
+GCACAAATAGCCGGAAGCCAAGGCGTTGTTCCAGATCGCTAAACTGGTGAGACAGGGCGG
+ATTGCGTCTGATGCAACGTCGCCGCAGCGGCTGCGAGCGAGCCGCAGTTCCGCAACGCTT
+GTAGCGTTTTCAGGTGTTTTACTTCGATCATGAAAGTCCTTCACTTCGGCATGAATAATT
+TGCGCTTGAGGAATATACAGTAACCGCCAATTATGGATGTGTAAACATCTGGACGGCTAA
+AATCCTTCGTCTTTTAAATTTATGGTGCGTTGGCTGCGTTTCTCCACCCCGGTCACTTAC
+TTCAGTAAGCTCCCGGGGATGAATAAACTTGCCGCCTTCCCTAAATTCAAAATCCATAGG
+ATTTACATATAATTAGAGGAAGAAAAAATGACAATATTGAATCACACCCTCGGTTTCCCT
+CGCGTTGGCCTGCGTCGCGAGCTGAAAAAAGCGCAAGAAAGTTATTGGGCGGGGAACTCC
+ACGCGTGAAGAACTGCTGGCGGTAGGGCGTGAATTGCGTGCTCGTCACTGGGATCAACAA
+AAGCAAGCGGGTATCGACCTGCTGCCGGTGGGCGATTTTGCCTGGTACGATCATGTACTG
+ACCACCAGTCTGCTGCTGGGTAACGTTCCGGCGCGTCATCAGAACAAAGATGGTTCGGTA
+GATATCGACACCCTGTTCCGTATTGGTCGTGGACGTGCGCCGACTGGCGAACCTGCGGCG
+GCAGCGGAAATGACCAAATGGTTTAACACCAACTATCACTACATGGTGCCGGAGTTCGTT
+AAAGGCCAACAGTTCAAACTGACCTGGACGCAGCTGCTGGACGAAGTGGACGAGGCGCTG
+GCGCTGGGCCACAAGGTGAAACCTGTGCTGCTGGGGCCGGTTACCTGGCTGTGGCTGGGG
+AAAGTGAAAGGTGAACAATTTGACCGCCTGAGCCTGCTGAACGACATTCTGCCGGTTTAT
+CAGCAAGTGCTGGCAGAACTGGCGAAACGCGGCATCGAGTGGGTACAGATTGATGAACCC
+GCGCTGGTACTGGAACTACCACAGGCGTGGCTGGACGCATACAAACCCGCTTACGACGCG
+CTCCAGGGACAGGTGAAACTGCTGCTGACCACCTATTTTGAAGGCGTAACGCCAAATCTC
+GACACGATTACTGCGCTGCCTGTTCAGGGTCTGCATGTTGACCTCGTACATGGTAAAGAT
+GACGTTGCTGAACTGCACAAGCGCCTGCCTTCTGACTGGTTGCTGTCTGCGGGTCTGATC
+AATGGTCGTAACGTCTGGCGCGCCGATCTTACCGAGAAATATGCGCAAATTAAGGACATT
+GTCGGCAAACGTGATTTGTGGGTGGCATCTTCCTGCTCGTTGCTGCACAGCCCCATCGAC
+CTGAGCGTGGAAACGCGTCTTGATGCAGAAGTGAAAAGCTGGTTTGCCTTCGCCCTACAA
+AAATGCCATGAACTGGCACTGCTGCGCGATGCGCTGAACAGTGGTGACACGGCAGCTCTG
+GCAGAGTGGAGCGCCCCGATTCAGGCACGTCGTCACTCTACCCGCGTACATAATCCGGCG
+GTAGAAAAGCGTCTGGCGGCGATCACCGCCCAGGACAGCCAGCGTGCGAATGTCTATGAA
+GTGCGTGCTGAAGCCCAGCGTGCGCGTTTTAAACTGCCAGCGTGGCCGACCACCACGATT
+GGTTCCTTCCCGCAAACCACGGAAATTCGTACCCTGCGTCTGGATTTCAAAAAGGGCAAT
+CTCGACGCCAACAACTACCGCACGGGCATTGCGGAACATATCAAGCAGGCCATTGTTGAG
+CAGGAACGTTTGGGACTGGATGTGCTGGTACATGGCGAGGCCGAGCGTAATGACATGGTG
+GAATACTTTGGCGAGCACCTCGACGGATTTGTCTTTACGCAAAACGGTTGGGTACAGAGC
+TACGGTTCCCGCTGCGTGAAGCCACCGATTGTCATTGGTGACATTAGCCGCCCGGCACCG
+ATTACCGTGGAGTGGGCGAAGTATGCGCAATCGCTGACCGACAAACCGGTGAAAGGGATG
+CTGACGGGGCCGGTGACCATACTCTGCTGGTCGTTCCCGCGTGAAGATGTCAGCCGTGAA
+ACCATCGCCAAACAGATTGCGCTGGCGCTGCGTGATGAAGTGGCCGATCTGGAAGCCGCT
+GGAATTGGCATCATCCAGATTGACGAACCGGCGCTGCGCGAAGGTTTACCGCTGCGTCGT
+AGCGACTGGGATGCGTATCTCCAGTGGGGCGTAGAGGCCTTCCGTATCAACGCCGCCGTG
+GCGAAAGATGACACACAAATCCACACTCACATGTGTTATTGCGAGTTCAACGACATCATG
+GATTCGATTGCGGCGCTGGACGCAGACGTCATCACCATCGAAACCTCGCGTTCCGACATG
+GAGTTGCTGGAGTCGTTTGAAGAGTTTGATTATCCAAATGAAATCGGTCCTGGCGTCTAT
+GACATTCACTCGCCAAACGTACCGAGCGTGGAATGGATTGAAGCCTTGCTGAAGAAAGCG
+GCAAAACGCATTCCGGCAGAGCGCCTGTGGGTCAACCCGGACTGTGGCCTGAAAACGCGC
+GGCTGGCCAGAAACCCGCGCGGCACTGGCGAACATGGTGCAGGCGGCGCAGAACTTGCGT
+CGGGGGTAAAATCCAAACCGGGTGGTAATACCACCCGGTCTTTTCTCATTACAGCGACTT
+CTTCCCACCATACTGCTTAAACCATTCCAGCATACGCTGCCAGCCATCTTCTGCAGATGC
+GGCATGATAGCTCGGGCGATAATCAGCGTTGAATGCATGCCCGGCGTCCGGGTACACGAT
+AATCTCTGCTTTCGCATTAGCAGCCCGCAGCGCCTGGCGCATGGTTTCAACGCTCTCCTG
+CGGAATGCTGTTATCCTGACCACCATATAAGCCGAGAATCGGCGCGTTAAGATCGGTTGC
+GATATCAACAGGTTGTTTCGGTGAATTCAGCGACTTGTCGCCCGTCAGTTTGCCGTACCA
+CGCCACTGCGGCTTTTAGCTGTGGATTATGCGCGGCATACAGCCAGGTGATACGTCCACC
+CCAGCAGAATCCGGTGATCATTAAACGATGAACATCGCCGCCGTTGCGGGAAGCCCAACT
+GGCGACATGATCGAGATCGGCCAGCACCTGCGAGTCAGGCACTTTTGCTACCAGACCGCT
+AAGCAACGTGGGGATATCGGCAAAATCATTCGGATCGCCTTCGCGGAAGTAAAGTTCAGG
+TGCGATAGCCAGATACCCCTCCAGCGCCAGACGGCGACAAATGTCGCGGATATGTTCATG
+CACGCCAAAAATTTCCTGCACTACAATGACCACTGGCAGTGGGCCATCGCTTTGCTTTGG
+TCTGGCATGGTAAGCAGGCATGTTATCCCCTTGTGAAGGGATAGAGGTGAAGCCCGCCAC
+AATCGCGTCGTCCGGGGTCTGAACGATGGTCGAAGCGAGAGGCGATGCAGCAGGTGCAAA
+TCCAGATTGTTGTGTTGTTGCCATGGTATTCTCCGTACCCTTATAAAAATGTTGCGCAAT
+GTTAACTATAGTCAGCATGCAACAAATCACATTGCCTGAATCGGCTCATCTTTTATGCAG
+TCCTGCAGAATGAAGGGTGATTTATGTGATTTGCATCACTTTTGGTGGGTAAATTTATGC
+AACGCATTTGCGTCATGGTGATGAGTATCACGAAAAAATGTTAAACCCTTCGGTAAAGTG
+TCTTTTTGCTTCTTCTGACTAAACCGATTCACAGAGGAGTTGTATATGTCCAAGTCTGAT
+GTTTTTCATCTCGGCCTCACTAAAAACGATTTACAAGGGGCTACGCTTGCCATCGTCCCT
+GGCGACCCGGATCGTGTGGAAAAGATCGCCGCGCTGATGGATAAGCCGGTTAAGCTGGCA
+TCTCACCGCGAATTCACTACCTGGCGTGCAGAGCTGGATGGTAAACCTGTTATCGTCTGC
+TCTACCGGTATCGGCGGCCCGTCTACCTCTATTGCTGTTGAAGAGCTGGCACAGCTGGGC
+ATTCGCACCTTCCTGCGTATCGGTACAACGGGCGCTATTCAGCCGCATATTAATGTGGGT
+GATGTCCTGGTTACCACGGCGTCTGTCCGTCTGGATGGCGCGAGCCTGCACTTCGCACCG
+CTGGAATTCCCGGCTGTCGCTGATTTCGAATGTACGACTGCGCTGGTTGAAGCTGCGAAA
+TCCATTGGCGCGACAACTCACGTTGGCGTGACAGCTTCTTCTGATACCTTCTACCCAGGT
+CAGGAACGTTACGATACTTACTCTGGTCGCGTAGTTCGTCACTTTAAAGGTTCTATGGAA
+GAGTGGCAGGCGATGGGCGTAATGAACTATGAAATGGAATCTGCAACCCTGCTGACCATG
+TGTGCAAGTCAGGGCCTGCGTGCCGGTATGGTAGCGGGTGTTATCGTTAACCGCACCCAG
+CAAGAGATCCCGAATGCTGAGACGATGAAACAAACCGAAAGCCATGCGGTGAAAATCGTG
+GTGGAAGCGGCGCGTCGTCTGCTGTAATTCTCTTCTCCTGTCTGAAGGCCGACGCGTTCG
+GCCTTTTGTATTTTTGCGTAGCGCCTCGCAGGAAATGCCTTTCCAACTGGACGTTTGTAC
+AGCACAATTCTATTTTGTGCGGGTAAGTTGTTGCGTCAGGAGGCGTTGTGGATTTCTCAA
+TCATGGTTTACGCAGTTATTGCGTTGGTGGGTGTGGCAATTGGCTGGCTGTTTGCCAGTT
+ATCAACATGCGCAGCAAAAAGCCGAGCAATTAGCTGAACGTGAAGAGATGGTCGCGGAGT
+TAAGCGCGGCAAAACAACAAATTACCCAAAGCGAGCACTGGCGTGCAGAGTGCGAGTTAC
+TCAATAACGAAGTGCGCAGCCTGCAAAGTATTAACACCTCTCTGGAGGCCGATCTGCGTG
+AAGTAACCACGCGGATGGAAGCCGCACAGCAACATGCTGACGATAAAATTCGCCAGATGA
+TTAACAGCGAGCAGCGCCTCAGTGAGCAGTTTGAAAACCTCGCCAACCGTATTTTTGAGC
+ACAGCAATCGCCGGGTTGATGAGCAAAACCGTCAGAGTCTGAACAGCCTGTTGTCGCCGC
+TACGTGAACAACTGGACGGTTTCCGCCGTCAGGTTCAGGACAGCTTCGGTAAAGAAGCAC
+AAGAACGCCATACCCTGACCCACGAAATTCGCAATCTCCAGCAACTCAACGCGCAAATGG
+CCCAGGAAGCGATCAACCTGACGCGCGCGCTGAAAGGCGACAATAAAACCCAGGGCAACT
+GGGGCGAGGTAGTATTGACGCGGGTGCTGGAGGCTTCCGGTCTGCGTGAAGGGTATGAAT
+ATGAAACCCAGGTCAGCATCGAAAATGACGCCCGCTCGCGGATGCAGCCGGATGTCATCG
+TGCGCCTGCCGCAGGGAAAAGATGTGGTGATCGACGCCAAAATGACGCTGGTCGCCTATG
+AACGCTATTTTAACGCCGAAGACGACTACACCCGCGAAAGCGCGCTACAGGAACATATCG
+CGTCGGTGCGTAACCATATCCGTTTGCTGGGACGCAAAGATTATCAACAGCTGCCGGGGC
+TGCGAACTCTGGATTACGTGCTGATGTTTATTCCCGTTGAACCCGCTTTTTTACTGGCGC
+TTGACCGCCAGCCGGAGCTGATCACCGAAGCGTTGAAAAACAACATCATGCTGGTTAGCC
+CGACTACGCTGCTGGTGGCGCTGCGCACTATCGCCAACCTGTGGCGTTATGAGCATCAAA
+GCCGCAACGCCCAGCAAATCGCCGATCGTGCCAGCAAGCTGTACGACAAGATGCGTTTGT
+TCATCGATGACATGTCCGCGATTGGTCAAAGTCTCGACAAAGCGCAGGATAATTATCGGC
+AGGCAATGAAAAAACTCTCTTCAGGGCGCGGAAATGTGCTGGCGCAGGCAGAAGCGTTTC
+GCGGTTTAGGAGTAGAAATTAAACGCGAGATTAATCCGGATTTGGCTGAACAGGCGGTGA
+GCCAGGATGAAGAGTATCGACTTCGGTCGGTTCCGGAGCAGCCGAATGATGAAGCTTATC
+AACGCGATGATGAATATAATCAGCAGTCGCGCTAGCCCATTGGGAGTAGTTAAGCCGGGT
+AGAAATCTAGGGCATCGACGCCCAATCTGTTACACTTCTGGAACAATTTTTTGATGAGCA
+GGCATTGAGATGGTGGATAAGTCACAAGAAACGACGCACTTTGGTTTTCAGACCGTCGCG
+AAGGAACAAAAAGCGGATATGGTCGCCCACGTTTTCCATTCCGTGGCATCAAAATACGAT
+GTCATGAATGATTTGATGTCATTTGGTATTCATCGTTTGTGGAAGCGATTCACGATTGAT
+TGCAGCGGCGTACGCCGTGGGCAGACCGTGCTGGATCTGGCTGGTGGCACCGGCGACCTG
+ACAGCGAAATTCTCCCGCCTGGTCGGAGAAACTGGCAAAGTGGTCCTTGCTGATATCAAT
+GAATCCATGCTCAAAATGGGCCGCGAGAAGCTGCGTAATATCGGTGTGATTGGCAACGTT
+GAGTATGTTCAGGCGAACGCTGAGGCGCTGCCGTTCCCGGATAACACCTTTGATTGCATC
+ACCATTTCGTTTGGTCTGCGTAACGTCACCGACAAAGATAAAGCACTGCGTTCAATGTAT
+CGCGTGCTGAAACCCGGCGGCCGCCTGCTGGTGCTTGAGTTCTCGAAGCCAATTATCGAG
+CCGCTGAGCAAAGCCTATGATGCATACTCCTTCCATGTGCTGCCGCGTATTGGCTCACTG
+GTCGCGAACGACGCCGACAGCTACCGTTATCTGGCAGAATCCATCCGTATGCATCCCGAT
+CAGGATACCCTGAAAGCCATGATGCAGGATGCCGGATTCGAAAGTGTCGACTACTACAAT
+CTGACGGCAGGGGTTGTGGCGCTGCATCGTGGTTATAAGTTCTGACAGGAGACCGGAAAT
+GCCTTTTAAACCTTTAGTGACGGCAGGAATTGAAAGTCTGCTCAACACCTTCCTGTATCG
+CTCACCCGCGCTGAAAACGGCCCGCTCGCGTCTGCTGGGTAAAGTATTGCGCGTGGAGGT
+AAAAGGCTTTTCGACGTCATTGATTCTGGTGTTCAGCGAACGCCAGGTTGATGTACTGGG
+CGAATGGGCAGGCGATGCTGACTGCACCGTTATCGCCTACGCCAGTGTGTTGCCGAAACT
+TCGCGATCGCCAGCAGCTTACCGCACTGATTCGCAGTGGTGAGCTGGAAGTGCAGGGCGA
+TATTCAGGTGGTGCAAAACTTCGTTGCGCTGGCAGATCTGGCAGAGTTCGACCCTGCGGA
+ACTGCTGGCCCCTTATACCGGTGATATCGCCGCTGAAGGAATCAGCAAAGCCATGCGCGG
+AGGCGCAAAGTTCCTGCATCACGGCATTAAGCGCCAGCAACGTTATGTGGCGGAAGCCAT
+TACTGAAGAGTGGCGTATGGCACCCGGTCCGCTTGAAGTGGCCTGGTTTGCGGAAGAGAC
+GGCTGCCGTCGAGCGTGCTGTTGATGCCCTGACCAAACGGCTGGAAAAACTGGAGGCTAA
+ATGACGCCAGGTGAAGTACGGCGCCTATATTTCATCATTCGCACTTTTTTAAGCTACGGA
+CTTGATGAACTGATCCCCAAAATGCGTATCACCCTGCCGCTACGGCTATGGCGATACTCA
+TTATTCTGGATGCCAAATCGGCATAAAGACAAACTTTTAGGTGAGCGACTACGACTGGCC
+CTGCAAGAACTGGGGCCGGTTTGGATCAAGTTCGGGCAAATGTTATCAACCCGCCGCGAT
+CTTTTTCCACCGCATATTGCCGATCAGCTGGCGTTATTGCAGGACAAAGTTGCTCCGTTT
+GATGGCAAGCTGGCGAAGCAGCAGATTGAAGCTGCAATGGGCGGCTTGCCGGTAGAAGCG
+TGGTTTGACGATTTTGAAATCAAGCCGCTGGCTTCTGCTTCTATCGCCCAGGTTCATACC
+GCGCGATTGAAATCGAATGGTAAAGAGGTGGTGATTAAAGTCATCCGCCCGGATATTTTG
+CCGGTTATTAAAGCGGATCTGAAACTTATCTACCGTCTGGCTCGCTGGGTGCCGCGTTTG
+CTGCCGGATGGTCGCCGTCTGCGCCCAACCGAAGTGGTGCGCGAGTACGAAAAGACATTG
+ATTGATGAACTGAATTTGCTGCGGGAATCTGCCAACGCCATTCAGCTTCGGCGCAATTTT
+GAAGACAGCCCGATGCTCTACATCCCGGAAGTTTACCCTGACTATTGTAGTGAAGGGATG
+ATGGTGATGGAGCGCATTTACGGCATTCCGGTGTCTGATGTTGCGGCGCTGGAGAAAAAC
+GGCACTAACATGAAATTGCTGGCGGAACGCGGCGTGCAGGTGTTCTTCACTCAGGTCTTT
+CGCGACAGCTTTTTCCATGCCGATATGCACCCTGGCAACATCTTCGTAAGCTATGAACAC
+CCGGAAAACCCGAAATATATCGGCATTGATTGCGGGATTGTTGGCTCGCTAAACAAAGAA
+GATAAACGCTATCTGGCAGAAAACTTTATCGCCTTCTTTAATCGCGACTATCGCAAAGTG
+GCAGAGCTACACGTCGATTCTGGCTGGGTGCCACCAGATACCAACGTTGAAGAGTTCGAA
+TTTGCCATTCGTACGGTCTGTGAACCTATCTTTGAGAAACCGCTGGCCGAAATTTCGTTT
+GGACATGTACTGTTAAATCTGTTTAATACGGCGCGTCGCTTCAATATGGAAGTGCAGCCG
+CAACTGGTGTTACTCCAGAAAACCCTGCTCTACGTCGAAGGGGTAGGACGCCAGCTTTAT
+CCGCAACTCGATTTATGGAAAACGGCGAAGCCTTTCCTGGAGTCGTGGATTAAAGATCAG
+GTCGGTATTCCTGCGCTGGTGAGAGCATTTAAAGAAAAAGCGCCGTTCTGGGTCGAAAAA
+ATGCCAGAACTGCCTGAATTGGTTTACGACAGTTTGCGCCAGGGCAAGTATTTACAGCAC
+AGTGTTGATAAGATTGCCCGCGAGCTTCAGTCAAATCATGTACGTCAGGGACAATCGCGT
+TATTTTCTCGGAATTGGCGCTACGTTAGTATTAAGTGGCACATTCTTGTTGGTCAGCCGA
+CCTGAATGGGGGCTGATGCCCGGCTGGTTAATGGCAGGTGGTCTGATCGCCTGGTTTGTC
+GGTTGGCGCAAAACACGCTGATTTTTTCATCGCTCAAGGCGGGCCGTGTAACGTATAATG
+CGGCTTTGTTTAATCATCATCTACCACAGAGGAACATGTATGGGTGGTATCAGTATTTGG
+CAGTTATTGATTATTGCCGTCATCGTTGTACTGCTTTTTGGCACCAAAAAGCTCGGCTCC
+ATCGGTTCCGATCTTGGTGCGTCGATCAAAGGCTTTAAAAAAGCAATGAGCGATGATGAA
+CCAAAGCAGGATAAAACCAGTCAGGATGCTGATTTTACTGCGAAAACTATCGCCGATAAG
+CAGGCGGATACGAATCAGGAACAGGCTAAAACAGAAGACGCGAAGCGCCACGATAAAGAG
+CAGGTGTAATCCGTGTTTGATATCGGTTTTAGCGAACTGCTATTGGTGTTCATCATCGGC
+CTCGTCGTTCTGGGGCCGCAACGACTGCCTGTGGCGGTAAAAACGGTAGCGGGCTGGATT
+CGCGCGTTGCGTTCACTGGCGACAACGGTGCAGAACGAACTGACCCAGGAGTTAAAACTC
+CAGGAGTTTCAGGACAGTCTGAAAAAGGTTGAAAAGGCGAGCCTCACTAACCTGACGCCC
+GAACTGAAAGCGTCGATGGATGAACTACGCCAGGCCGCGGAGTCGATGAAGCGTTCCTAC
+GTTGCAAACGATCCTGAAAAGGCGAGCGATGAAGCGCACACCATCCATAACCCGGTGGTG
+AAAGATAATGAAGCTGCGCATGAGGGCGTAACGCCTGCCGCTGCACAAACGCAGGCCAGT
+TCGCCGGAACAGAAGCCAGAAACCACGCCAGAGCCGGTGGTAAAACCTGCTGCGGACGCT
+GAACCGAAAACCGCTGCACCTTCCCCTTCGTCGAGTGATAAACCGTAAACATGTCTGTAG
+AAGATACTCAACCGCTTATCACGCATCTGATTGAGCTGCGTAAGCGTCTGCTGAACTGCA
+TTATCGCGGTGATCGTGATATTCCTGTGTCTGGTCTATTTCGCCAATGACATCTATCACC
+TGGTATCCGCGCCATTGATCAAGCAGTTGCCGCAAGGTTCAACGATGATCGCCACCGACG
+TGGCCTCGCCGTTCTTTACGCCGATCAAGCTGACCTTTATGGTGTCGCTGATTCTGTCAG
+CGCCGGTGATTCTCTATCAGGTGTGGGCATTTATCGCCCCAGCGCTGTATAAGCATGAAC
+GTCGCCTGGTGGTGCCGCTGCTGGTTTCCAGCTCTCTGCTGTTTTATATCGGCATGGCAT
+TCGCCTACTTTGTGGTCTTTCCGCTGGCATTTGGCTTCCTTGCCAATACCGCGCCGGAAG
+GGGTGCAGGTATCCACCGACATCGCCAGCTATTTAAGCTTCGTTATGGCGCTGTTTATGG
+CGTTTGGTGTCTCCTTTGAAGTGCCGGTAGCAATTGTGCTGCTGTGCTGGATGGGGATTA
+CCTCGCCAGAAGACTTACGCAAAAAACGCCCGTATGTGCTGGTTGGTGCATTCGTTGTCG
+GGATGTTGCTGACGCCGCCGGATGTCTTCTCGCAAACGCTGTTGGCGATCCCGATGTACT
+GTCTGTTTGAAATCGGTGTCTTCTTCTCACGCTTTTACGTTGGTAAAGGGCGAAATCGGG
+AAGAGGAAAACGACGCTGAAGCAGAAAGCGAAAAAACTGAAGAATAAATTCAACCGCCCG
+TCAGGGCGGTTGTCATATGGAGTACAGGATGTTTGATATCGGCGTTAATTTGACCAGTTC
+GCAATTTGCGAAAGACCGTGATGATGTTGTAGCGTGCGCTTTTGACGCGGGAGTTAATGG
+GCTACTCATCACCGGCACTAACCTGCGTGAAAGCCAGCAGGCGCAAAAGCTGGCGCGTCA
+GTATTCGTCCTGTTGGTCAACGGCGGGCGTACATCCTCACGACAGCAGCCAGTGGCAAGC
+TGCGACTGAAGAAGCGATTATTGAGCTGGCCGCGCAGCCAGAAGTGGTGGCGATTGGTGA
+ATGTGGTCTCGACTTTAACCGCAACTTTTCGACGCCGGAAGAGCAGGAACGCGCTTTTGT
+TGCCCAGCTACGCATTGCCGCAGATTTAAACATGCCGGTATTTATGCACTGTCGCGATGC
+CCACGAGCGGTTTATGACATTGCTGGAGCCGTGGCTGGATAAACTGCCTGGTGCGGTTCT
+TCATTGCTTTACCGGCACACGCGAAGAGATGCAGGCGTGCGTGGCGCATGGAATTTATAT
+CGGCATTACCGGTTGGGTTTGCGATGAACGACGCGGACTGGAGCTGCGGGAACTTTTGCC
+GTTGATTCCGGCGGAAAAATTACTGATCGAAACTGATGCGCCGTATCTGCTCCCTCGCGA
+TCTCACGCCAAAGCCATCATCCCGGCGCAACGAGCCAGCCCATCTGCCCCATATTTTGCA
+ACGTATTGCGCACTGGCGTGGAGAAGATGCCGCATGGCTGGCTGCCACCACGGATGCTAA
+TGTCAAAACACTGTTTGGGATTGCGTTTTAGAGTTTGCGGAACTCGGTATTCTTCACACT
+GTGCTTAATCTCTTTATTAATAAGATTAAGCAATAGCATGGAGCGAGCCTCACCATCGGG
+TTCGGTGAAAATGGCCTGAAAGCCTTCGAACGCGCCTTCGGTAATAATCACCTTATCACC
+CGGATAAGGGGTTGCCGGATCGACAATGTCTTTCGGTTTATATACCGATAGCTGATGAAT
+AACCGCCGATGGGACTATCGCTGGCGACGCGCCAAAGCGCACGAAGTGGCTGACACCGCG
+GGTCGCGTTGATAGTCGTGGTATGAATCACTTCTGGGTCAAATTCCACAAACAGGTAGTT
+GGGGAACAATGGCTCACTGACTGCAGTACGTTTTCCACGCACGATTTTTTCCAGGGTGAT
+CATCGGTGCCAGGCAATTCACAGCCTGTCTTTCGAGGTGTTCCTGGGCACGTTGAAGTTG
+CCCGCGCTTGCAGTACAGTAAATACCAGGATTGCATAATGACTCTTATCCGTTTAATCGG
+GGCGCAAGGATAGCAAAAGCTTTACGCTAAGTTAATTATATTCCCCGGTTTGCGTTATAC
+CGTCAGAGTTCACGCTAATTTAACAAATTTACAGCATCGCAAAGATGAACGCCGTATAAT
+GGGCGCAGATTAAGAGGCTACAATGGACGCCATGAAATATAACGATTTACGCGACTTCTT
+GACGCTGCTTGAACAGCAGGGTGAGCTAAAACGTATCACGCTCCCGGTGGATCCGCATCT
+GGAAATCACTGAAATTGCTGACCGCACTTTGCGTGCCGGTGGGCCTGCGCTGTTGTTCGA
+AAACCCTAAAGGCTACTCAATGCCGGTGCTGTGCAACCTGTTCGGTACGCCAAAGCGCGT
+GGCGATGGGCATGGGGCAGGAAGATGTTTCGGCGCTGCGTGAAGTTGGTAAATTATTGGC
+GTTTCTGAAAGAGCCGGAGCCGCCAAAAGGTTTCCGCGACCTGTTTGATAAACTGCCGCA
+GTTTAAGCAAGTATTGAACATGCCGACAAAGCGGCTGCGTGGTGCGCCCTGCCAACAAAA
+AATCGTCTCTGGCGATGACGTCGATCTCAATCGCATTCCCATTATGACCTGCTGGCCGGA
+AGATGCCGCGCCGCTGATTACCTGGGGGCTGACAGTGACGCGCGGCCCACATAAAGAGCG
+GCAGAATCTGGGCATTTATCGCCAGCAGCTGATTGGTAAAAACAAACTGATTATGCGCTG
+GCTGTCGCATCGCGGCGGCGCGCTGGATTATCAGGAGTGGTGTGCGGCGCATCCGGGCGA
+ACGTTTCCCGGTTTCTGTGGCGCTGGGTGCCGATCCCGCCACGATTCTCGGTGCAGTCAC
+TCCCGTTCCGGATACGCTTTCAGAGTATGCGTTTGCCGGATTGCTACGTGGCACCAAGAC
+CGAAGTGGTGAAGTGTATCTCCAATGATCTTGAAGTGCCCGCCAGTGCGGAGATTGTGCT
+GGAAGGGTATATCGAACAAGGCGAAACTGCGCCGGAAGGGCCGTATGGCGACCACACCGG
+TTACTATAATGAAGTCGATAGTTTCCCGGTATTTACCGTGACGCATATTACCCAGCGTGA
+AGATGCGATTTACCATTCCACCTATACCGGGCGTCCGCCAGATGAGCCCGCGGTGCTGGG
+TGTCGCACTGAACGAAGTGTTTGTGCCGATTCTGCAAAAACAGTTCCCGGAAATTGTCGA
+TTTTTACCTGCCGCCGGAAGGCTGCTCTTATCGCCTGGCGGTAGTGACAATCAAAAAACA
+GTACGCCGGACACGCGAAGCGCGTCATGATGGGCGTCTGGTCGTTCTTACGCCAGTTTAT
+GTACACTAAATTTGTGATCGTTTGCGATGATGACGTTAACGCACGCGACTGGAACGATGT
+GATTTGGGCGATTACCACCCGTATGGACCCGGCGCGGGATACTGTTCTGGTAGAAAATAC
+GCCTATTGATTATCTGGATTTTGCCTCGCCTGTCTCCGGGCTGGGTTCAAAAATGGGGCT
+GGATGCCACGAATAAATGGCCGGGGGAAACCCAGCGTGAATGGGGACGTCCCATCAAAAA
+AGATCCAGATGTTGTCGCGCATATTGACGCCATCTGGGATGAACTGGCTATTTTTAACAA
+CGGTAAAAGCGCCTGATGCGCGTTTGTTTTGCCCTATTTATCGATCCGACAGAGAAAGCG
+CATGACAACCTTAAGCTGTAAAGTGACCTCGGTAGAAGCTATCACGGATACCGTATATCG
+TGTCCGCATCGTGCCAGACGCGGCCTTTTCTTTTCGTGCTGGTCAGTATTTGATGGTAGT
+GATGGATGAGCGCGACAAACGTCCGTTCTCAATGGCTTCGACGCCGGATGAAAAAGGGTT
+TATCGAGCTGCATATTGGCGCTTCTGAAATCAACCTTTACGCGAAAGCAGTCATGGACCG
+CATCCTCAAAGATCATCAAATCGTGGTCGACATTCCCCACGGAGAAGCGTGGCTGCGCGA
+TGATGAAGAGCGTCCGATGATTTTGATTGCGGGCGGCACCGGGTTCTCTTATGCCCGCTC
+GATTTTGCTGACAGCGTTGGCGCGTAACCCAAACCGTGATATCACCATTTACTGGGGCGG
+GCGTGAAGAGCAGCATCTGTATGATCTCTGCGAGCTTGAGGCGCTTTCGTTGAAGCATCC
+TGGTCTGCAAGTGGTGCCGGTGGTTGAACAACCGGAAGCGGGCTGGCGTGGGCGTACTGG
+CACCGTGTTAACGGCGGTATTGCAGGATCACGGTACGCTGGCAGAGCATGATATCTATAT
+TGCCGGACGTTTTGAGATGGCGAAAATTGCCCGCGATCTGTTTTGCAGTGAGCGTAATGC
+GCGGGAAGATCGCCTGTTTGGCGATGCGTTTGCATTTATCTGAGATATAAAAAAACCCGC
+CCCTGACAGGCGGGAAGAACGGCAACTAAACTGTTATTCAGTGGCATTTAGATCTATGAC
+GTATCTGGCAAACCATGCCCGATGCGACGCTGTCGCGTCTTATCGTGCCTACAAATAGTC
+CGAACCGTAGGCCGGATAAGGCGTTTACGCCGCATCCGGCAATTGGTGCATGATGCCTGA
+TGCGACGCTGGCGCGTCTTATCAGGCCTACATTGGTGCCGGATCGGTAGACCGGATAAGG
+CGTTCACGCCGCATCCGGCAAGTGGTTAAACCCGCTCAAACACCGTCGCAATACCCTGAC
+CCAGACCGATACACATCGTCGCCAGACCAAACTGAACGTCTTTGCGTTCCATCAGATTCA
+GCAGCGTGGTGCTGATACGCGCACCGGAACAACCCAGCGGATGACCCAGCGCGATCGCGC
+CACCGTTGAGGTTGATCTTCTCGTCAATCTGCTCAATTAGTCCCAGATCTTTAATACATG
+GCAGGATCTGCGCGGCAAAGGCTTCGTTCATTTCAAACACGCCGATATCGCTGGCAGAAA
+GCCCCGCTTTTTTCAGCGCCAGTTTCGAGGCCGGAACCGGGCCGTAACCCATAATCGATG
+GGTCACAACCAACGACCGCCATCGAACGCACACGAGCGCGCGGCTTAAGACCTAATTCAT
+GGGCGCGGCTTTCACTCATCACCAGCATGGCAGCTGCGCCATCGGAAAGTGCAGAAGATG
+TGCCCGCCGTTACCATACCGTTTACTGGATCAAACGCCGGACGCAGCGTGGCGAGGGCTT
+CCACGGTGGTTTCCGGGCGAATCACTTCGTCGTAATTAAACTGCTTCAGGACGCCGTCGG
+CATCGTGACCACCGGTCGGGATGATTTCATTTTTAAATGCGGCCGACTGCGTGGCGGCCC
+AGGCGCGGGCGTGTGACCGCGCGGCAAAGGCATCCTGCATTTCACGGCTGATACCGTGCA
+TACGCGCCAGCATTTCTGCCGTTAAGCCCATCATGCCCGCCGCTTTGGCGACATTGCGGC
+TCAGGCCGGGGTGAAAATCGACGCCGTGACTCATCGGCACATGGCCCATATGCTCCACGC
+CGCCAACCAGACATGCCTGCGCATCGCCAGTCATGATCATTCGTGCTGCGTCATGCAGTG
+CCTGCATGGATGAACCACACAAGCGATTAACGGTAACCGCCGGGACAGAGTGTGGTACTT
+CTGCCAGCAGCGCCGCGTTACGGGCGATATTAAAACCCTGCTCCAGCGTCTGCTGCACAC
+AACCCCAGTAAATATCGTCGAGGGCCGCCGCTTCCAGCGCCGGGTTACGCGCCAGCAGGC
+TACGCATTAAATGAGCGGAGAGATCTTCTGCACGCACGTTACGAAAAGCACCGCCCTTCG
+AACGGCCCATCGGGGTGCGAATTGCATCGACAATGACAACCTGTTCCATTGTGACTCCTT
+AAGCCGTTTTCAGGTCGCCAACCGGACGGGCTGGCTCAACCGGAGGATAGTACGGTTCGT
+TATGACGCGCTTTATTACGCAGACCTTCCGGCACTTCATACAGCGGGCCGAGGTGCTGAT
+ATTGCTGTGCCATATCGAGGTATTTTGCGCTACCGAGGGTGTCCAGCCAGCGGAACGCGC
+CGCCGTGGAACGGAGGGAAGCCCAGGCCGTAGACCAGCGCCATATCCGCTTCCGCCGGAG
+TGGCGATAATGCCTTCCTCCAGACAGCGCACCACTTCGTTGACCATCGGGATCATCATGC
+GGGCGATAATCTCTTCTTCGCTGAAATCGCGCTTCGGCTGGCTCACTTCTGCCAGCAGGT
+CTTCAACGGCGGCGTCTTCTTCTTTCTTCGGCTTACCTTTGCTGTCTTCTTTATAACGCC
+AGAAACCGAGGCCGTTCTTCTGACCAAAGCGGTTGGCATCAAACAGCGCGTCGATGGCAT
+CGCGGTAATCTTTCTGCATCCGCTGCGGGAAGCCTGCTGCCATGACAGCCTGAGCGTGAT
+GCGCGGTATCAATGCCCACAACGTCCAGCAGATATGCCGGGCCCATCGGCCAGCCAAACT
+GTTTTTCCATCACTTTGTCGATCTTGCGGAAATCCGCGCCGTCGCGCAGCAGCTGGCTGA
+AACCGGCGAAATACGGGAACAGCACGCGGTTAACAAAGAAGCCGGGGCAGTCGTTAACCA
+CAATCGGCGTCTTGCCCATCTTGCTCGCCCAGGCGACAACTTTCGCGATGGTTTCGTCGG
+AGCTTTTCTCGCCGCGAATAATTTCTACCAACGGCATTCGGTGGACCGGGTTAAAGAAGT
+GCATCCCGCAGAAGTTTTCCGGGCGTTCCAGCGCGTTGGCCAGTTCGCTGATAGGAATGG
+TTGAAGTGTTAGACGCCAGCACGGTATCCTGGCGTACTTTTTGTTCGGTTTCTGCCAGTA
+CGGCTTTTTTCACTTTCGGGTTTTCAACAACCGCTTCTACCACAATATCCACGCGGTCAA
+ATCCGGCGTAGTCGAGCGTTGGGTGGATTGTGGAGATCACGCCAGCCAGTTTCAGACC
+>NODE_11_length_39995_cov_63.1687_ID_21
+CTGCCCAAACTGGTGCAGGCGGCGAACGGGGCAGCCCTCGCGCAGCTTCAGGTCAAGCTG
+TCGAACAACGACTACACCCCCGCCCGCACCCTGCAAGACGCCCAGCTCGCGCTCGCCAAC
+GCCCAGCGCACCCTGAACGACGCGACGCGGGCGAGCAGCACCGGGGTCAGCGACGCCTAC
+CGCGCCGTGCAAAACGCCCAGCAGCAAGTGAACATCGCCCGGCAGCAGGCGACCAACGCG
+CAGACCGCGCTCACCCAAGCGCAGGCCCGCCTCAAGGCCGGCACCGCCGCCGCCGTCGAA
+GTTCAGCAGGCGCAGGTGCAGGCGCAACAGGCGCAACTCGGCGTGCAGCAGGCGCAAGAC
+GGCCTGTGGCAGGCGCTCGCCGCGCTCGGGGCCGCGAGCGGGACGGACGTGACCGGGCTG
+GTGAAATAGTGGGGACTGGTGAAATAGTGGGGGCTGGTGAAGTAGTGGGCGGCCCTCTTC
+AGATGGCGCGGCGGGTGACCAGAGGAGCCGCGCCGCGCCTGGCCGGTGCCCTGCTTCTCA
+CGGCGCTGCTTGCCGGGTGCTCGCCCAAGACCGAAACGAAAACCAACGACCTCGACGCCG
+CGCTTCCCAAGACGACCACCCTCAGCGTGCAGACGGTGACGGCGAGGGCGGGCACGCTGA
+CCGCCCAGCGCAGCGCGAGCGCGACCATTCAGGCCGAGCGCGACAGCCAGGTGGCGACCC
+AGTCCTCCGGCGCCGTGCAGAGCATTCCCGTGAGTCAGGGCGAGGCGGTGGCGAAAGGCG
+ACGTGCTCGTCAAACTCGACGACACCGCTCAACAGCAAGCGCTCGACAACGCCCGGCTGC
+AACAGCGCCAGGCCCAGATCAGCCTCGACCAGACGCGGCAAAGTACGTCCCAGGGGACCG
+GCGCCCTGCAGGCGAGCGTGACCTCGGCGCAGGCGGCGCTCGCGCAGGCCGAGCAAAACG
+CCCAGAGCGCCGAGAAGCTCTACGGCCTCGGCGGCATCAGCCTCGCGGACGTGCAGGCGG
+CCCGCTCGCAGCTCGCGCAGGCCCAGGCGCAACTCGCGCAGGCCCGCAATACCCTGGAGC
+AAAACGGGCGCAGCGCCGGCAACTCGGTGCCGCTCGCGCAGGTGCAGCTCGACACGGCCC
+GCACTGCCGTGCGCCAGGCCGAGCAAAACCTCAGCCGCACCGCCGTCCGTGCCCCCTTCG
+CTGGTACGGTGGCCGACGTGCTGACCGAGGTCGGCGAGTTCGCCGGGCAGGGCACCCCGG
+TCATCCGCCTCGTGGACCCCGGCAGCGTCCGCGCCCGCGTGGGCGTGCCCACCGCCGACG
+CCGCCGCGCTCACCGAGGGCGTCAAGTTCAACCTCAGCTACGGCGGCAAAAGCTACGTGG
+CGACGGTGGTAGACAGCTCGGGTATCGCCGGCAAAGACCGCCTGGTGCCGATTACCGCGA
+CCATTGAGGGCGGCAATGCTCTGCCCGTCGGCGCCGCCGCCCGCGCCAGCTACCGCGCCA
+CACTCGGCAGCGGCCTGCTGATTCCGGCGAGTGCCCTTCAGGTGGAAGGCGGTGAAAACG
+CCGTCTACGTCGCCCGCAGTGGCAAGGCCGAGCGCGAAGTCGTGCAGGTCGTCGCCGAGA
+GCGGCAACCGGGTGGTGGTGTCGGGCCTTCAGGACGGCGACGCGGTCATCAGCCCCCTGC
+CCGCCGGGGTGCAGGACGGGGCGAAGGTGGTGGTGAAGTGAGGGCCATAGCGCACAGAGT
+CGAGGGCCGGGGGGGAGAAAACCCCTCACCCCTTGCTGCGCAAGGCCCGCTGCTTCGCAG
+CTTTGCAAGTCTCCCCTTGGGAGAGGGTCAACAGCGCAAAAACCTTAAGCCTTCTATGAC
+CCTCGCCCCTTGCGGGAGAGGGCCTGCCGCAGGCAGGGGTGAGGGGGCCAGCCCGTCCTG
+TCTTTCCCCACACGCCCCCCAGGTCACCCCATGAGCACCCACTTCGACGAAGCCGAATTC
+AGGTCCGGCGGCACCCTGCCCGACGGCACACCCGAGCCGCAGATTCACCCGCTGGTGCGC
+TTCAGCGTCAAGAACTACGTCTTTTCCATCGGCATCTTCGTGATGGTGGTCCTGCTGGGG
+CTGGTGGCGACCTTCCGGCTGGGGGTCGAGCTGCTGCCCAACTTCGAGGTGCCGGTGCTG
+GCGGTGAGCACGTCCTACCCCGGCGCCAATCCCGACCAGGTGGACCGCGAGGTCAGCCGC
+CGGGTGGAAGACGCGGTGAGCACGCTCTCGGGCGTCACCGACATCAACACGACCTCGGTC
+AGCAATCAGTCGGCGGTGGTTATCACCTTCAGCGACTCGACCAACATTGACTCGGCGGCC
+AACTCGGTGTCGCAGGCGGTGGCGGCGATTCGCGGCACCCTGCCCGACGGCGCGGAGGCT
+CCGGTGGTGCAGAAATTCGACCCCAACGCCCAGCCGATTCTGACGCTGGCGCTGCTCGGC
+GGCGCGGCGCGGCCCAGCGAGGTGACGACCTTTGCCGAGGACACGCTGGTGCCCCGCCTG
+CAACGGGTGGAGGGCGTGGCCGACGTGACCGTGACCGGCGGGCCCGAGCGGCAGGTGCAG
+GTCTTGCTTGACCCGGCGCGGCTGCAAGGCTTTGACCTCGCGCCCGCACGAATCAGCGGG
+GCCATCGGTTCCTCGGCGCTCGACCTGCCTGCCGGGACGCTCGACCGGGGCGGCTCGACC
+ACCTCCTACAGCACCCGCAACACCCCGCGCAGCGCCGCCGACGTGGCGCGCATCGTGGTG
+GACCCGTCCACCGGCCTGCGCGTGAGCGACGTGGCGACGGTGCGTGACGCCAGCGCGGCG
+GCCAACAGCTACGCCCGCGTCAACGGGCAGCCCGCCGTGCTGCTCGGCGTCCGCAAGGCG
+AGCGGCACCAACTCGGTGGCCGTGACCGACAACGTGCGCGCGGCGATGGAAGCCCAAAAG
+CTCCCGCCGGGCTACCGCCTCACCCTCGCCAGCGACACCACGACCAGCACGCGGGCCACA
+GTGAACGACACCTTCCGGGAATTCCTGATTGCGGTGGGCGCGGTAGGTCTGATTTGCCTG
+CTGTTCCTGGGACGGCTCAACACCGTGTTCGCCGTCATTCTCGCCATTCCGATTTCCATC
+AGCGCCGCGCCGCTGCTCTTCGGGACGCTCGGCTTTACCTTCAACATCATCACGCTGCTC
+GCCATCATCGTCGCCATCGGCATCGTGGTGGACGACTCTATCGTGGTGGCGGAGAACGTG
+CAGCGCTACCGCGACCTGGGCTACTCGCCGCTGCGGAGTGTGCTGCTCGGCGGCTCGGAA
+GTGTTTTCCGCCGTCACCGCCGCGAGTTTCTCGCTGCTGGCGGTCCTCATTCCGCTGAGC
+CTGATGCCGGGCATCCTGGGGCAGTTCTTCAAACAGTTCGGGCTCGGCATCGCCGCCGCC
+ATCGTGCTGAGCTGGCTGGAAAGTCTGCTGTTCCTCACCGTCCGCATGGCGTACACCCGC
+GAACCCGCCCGCATCACCTGGGCTGACCTGCCCGCTGTGCTGCGCCGGCTGCCGCTCACT
+TTCCGCGAGTCGCTGAGCGGCGTGAAGACCTTCTGGGGCCTGCTCGGGCTGGCGCTGGCC
+GGGGCCGCGACGTACTTTGGCCTGCACCGCGCCGGGCTGCCCGCTGCCGCCGCCGGGGTG
+CTGTGCGTCCTCCTCGCGCCGGTCGTGCTGACTGTCGTCCGCTACCTCCTCACGGTGCTG
+TATGCCCTGCTCGAAGCGCTGACCGAGACGCTCCACACCCTCACGCTGAGTGGCGTCAAC
+CGCGCGGCCAAAGCCTACGCCCGCTCGCTGGCAGGCGCCCTGCGGCGGCCCGGCGTGGTG
+ATGCTGGTCGCGGGCCTCTTTCTGCTCAGTGCGCCGCTCGCCCTGCGCGGGCTGGGCTTT
+GCCTTCGTCCCGGCGAGCGACAGCGGCATTGCGACCATCAGCCTGACCCTGCCGGTGGGC
+ACGCCGCTGGCCGTGACGGATGAGCTGACCCGGCAGGTGGAAGACAAGCTGCTCGCGCAC
+CGTGAAGTCAAGCTGGTGCAGACCGCTTCGGGCAGCAGCGGGGTCCTCGGCGGTGCTAAC
+GCCAACACCTCCGACCTCACGCTGACGCTGATTCCCAAAGCCGAGCGTCCCGGCATCGAC
+GAGTTGCTGGAACGCTACCGCCGTGAACTTGCCCCGCTGGTCGCCCGCTACCCCGGCACC
+GAATTGCTGGTGGCGGGGCAGGCGGTGGGGCCGGGCGACAGTTCGGACATCTCGCTCGCG
+CTCACCGCCCCGAGTCAGTCGCTGCTCGAAGAACGCAACCGCGCGGTGGTCCGGCTGCTG
+AGTGCCGACCCCAACATCCGCACGGTGAAAAGCAGCCTCTCGGCCACCCGGCAGGAGCGC
+ACCTTCGTTCCCGACCCGCTGCGGCTGAGCGGCACGGGCCTGAGTGCGAGCGACGTGGCG
+CAGGCGCTGCGAACCTACAACGACGGCACCGTGGCCGGGCAGGTCCGCGACGGCGACCGC
+AGCGTGGACATCGTGGTGCGGCTCGACCCCGCGCTGGTGTCGGGCGAACAGAGTCTGCTC
+TCGCAGACGCTCTACTCGCAGGCCCTCGGCGCCAACGTGCCGCTCTCCAGCCTGGGCCGC
+TTCGAGGTCGCGCAGGCGCCCGCCACGCTGCGGCGCTTCAACAAGGCGTACACCGCCACG
+CTCGACATCAACCTCGTGTCGGGCGGTCCCAACCCCTTCGCCTATCAGAAAGACGTGCAG
+CAGCGCGTCGAAAAGGCCGGGCTGCTCGCGGGCGGCGTGACCCTCGGCAACGCCAACTCC
+TTCGGCAGCGCGGGGCTGACCGGCGACCTGCTGTTCTACGGCCCGATTCTGATGGTGGCG
+GCGGTGCTGCTCACTTATCTGGTGCTGGGCAGTCAGTTCAACTCGTTCCGTTACCCGATT
+TATCTGTTGCTCCCGATTCCGCTCGCCATCGTGGGGGCGCTGTGGACGCTGCACCTGTTT
+GGCGTCAATCTGGACGTGATTACGGTGCTGGGGATGGTGATTTTGCTCGGCCTCTCCACC
+AAAAACTCCATCCTGTACCTCGAATTCGTGACCGAACGCGCCCGCGTCCTGCCGCTGCAC
+GAGGCGCTGCTCGAAGCCGCCGAACTGCGGTTTCGCCCCATCCTGATGACCACGCTGACG
+GTGCTGGTGATTTCCATTCCCCTCATCCTCGGCCACGGCGAGGGCGCCGAATTCCGCCGC
+GGCCTGGGCATCGTGATTCTGGGGGGCGTGGTGACGAGCACCCTGCTGACCTTCTACGTG
+GTGCCGAGCGTCTTCTGGCAGTTCGAGAAAAAGCGCATGGCCACGCCACAACCGAAATTG
+GAGCCGGTGGCTGGAGACTGAACCCTCGCTGAAACCGTGAAGAAATGGCGCATGTGCGGC
+CCTCTCCTACTAAGGAAGAGGGCCGCACGCTGTAGGGACGGGCTCATAAAGTTCTCTAAA
+GCATTTGACAGAAAAAGACACCCTCACCCCTGCCTTCGGCAGGCCCTCTCCCATCAAGGT
+AGAGGGTCAAAAATGCTCTAGAAAAGGCGAATCAGTGAACTTTATTGCGGCTGCAAGGGA
+GCCAGTACAGCCCGGCGTTGGCCTCGTTCGGGTTGGTCGAGCCCCAGCACCAGCCCTTGG
+CCCGGATGCGGCGCAGCGTGGCGTCACGTTTGTCGCACATGCTCTGGGTGCTTTTGGAAG
+AGTGCGCCGACTGGCAGACCTTCTCCTGGGCGATGGCCTGATGAATCAGCGACCGGACGG
+CGGGGTCGTGGGGCTGGTGGCTGGTGCCGATTGCGCCTGCACCAGCGGTTGAGGTGAGCA
+GGGTCGCGGCGAGCAAGAGGGGACGCAGAGTGTTCATGGCTGCACTGTGCGGGGGCAAGG
+TTGGAGGCGCGTGAAAAGTGACTTCAGGGGTTAGCGACCGCCGCTCATGTGCGGGAGGTC
+TTCCCGTTCGGCCCTCAGCCCCCTCGTTACTGCTCACGGAGGGGCTTTTGCATTTGCCCC
+CCGCCGTGTATATGCATAGAATATTCAGAATGCTGGGCAAGGAAATCGGAAAAGACCAAC
+GACAAAAGCGCATTCAGGACATCATCCTGCGGGAGAGTGTGTCCACGCAGGCCGAACTGG
+TCAAGCTGCTGGCGAAAGAAGGCGTGCAGGTCACGCAGGCCACCGTCAGCCGCGACATCA
+ACGAGCTGCGGCTGGTGCGGGTGCCCATCGGCAAGGGGCGGCACCGCTATGCCCTGGCGC
+AGTACGGCGGCGACAGCGACATCGAGGAGCAGCTCGCCCGCCTCTTTCAGAGCTTCGTGC
+AGGACGTGGACCGGGGCGAGAACATCCTGGTCATCCGCACCGCCGACGGGCACGCCTCGG
+GGGTCGCGCTGCTGCTCGACCGCTGGAAGCGCGACGACATCGTGGGTACGCTGGCGGGCG
+AGGACACCATCATGGTTGTGGCCCGCTCCACCCATGACGGCGAGAGCCTGATGGAAGAAT
+TCAACGCGCTGATGCTGGGGTAACAGCTCTCACAGCCCAGTCCAGAGCACAAAAAAGGCC
+CCCTTCCACACCTGGGAAGGGGCTTTTTCCTGGGCTGTTTCGGGCCGCTTATTCTTCGCG
+CAGCACGTAGCCGACGCCGCGCACCGTGTGAATCAGACGCCGCTCTCCGCCTTCTTCGAG
+CTTGCGGCGCAGGTAGCCGATGTACACGTCCACCACGTTGCTGCCGCCGGTATACTCGGG
+CCAGACCTTTTCCTCGATTTCAAAGCGCGAAAAGACCTTACCGGGGTTGCGGGCGAGCAG
+TTCGAGCAGTTCGAATTCCTTCGCCGAAAGTTCGACCCGGCGTCCGCCCCGGAAAATCTC
+GCGTCCATCGAGGTTCATCACCAGGTCGGCCACCCGCACTTCGCCCGTCACGGCGGGGTT
+GACTCGCCGCAGATGGGCGCGGACGCGGGCCAGCAGTTCCTCGATGGAAAAGGGCTTGAT
+GAGGTAGTCGTCGGCGCCCGAGTCCAGGCCCTCCACCTTGTCCTGAATGCCGTCCTTGGC
+GGTCAGGATGATGATGGGGGTGTTGCTCGTCTTGCGGATGCGGCGGGCGACCTCAAGGCC
+GTCGAGGACCGGCAGCATCAGGTCGAGAATCACCAGATCGGGGTTGACTTCGCGGAATTT
+CGACAAGCCGGTCACGCCGTCAAAGGCCACCTCGGTGGCGTAGCCCTCGGCGGCCAGTTC
+CAGCTCGATGAAGCGGGCAATATCTTTTTCGTCTTCGATGACGAGGACGAGCGGCTTGCG
+TTCCATGCCCGCAGTGTAATGAGTGCTCTCATGAGAAGGCGGCGCCCCGTCCTTAAGTTC
+TATTCATCACAAATGCTGGCGGGGGCGGGCAGCGCTGGGCCGTCACGCGGGTCACAGGTG
+AGCGCCGTACACTGCCGGACGTGACCACGGGCCGTTCCACTTCTTCGCCTTCCGCCTCGC
+CGGGCCAGGGCACGTCGGCGCAGGACCCGGCCCCCCGGCGCTGGCTGCTGCGGCCCTCGT
+CGCTGCAATTGCGGCTGACGTTGCTGTACGCGGCGCTGCTGGCGCTGATGCTCGCCTCGG
+TGTACGGTGCCGCGCTGGTGCTCATGCGCAGCAGCTTGATTACCGGGCTTGACGAGGGGA
+TGCGCAACACTTACAGCCAGTTCAGCGAGCTGGTGGCGCAACTTGCCCTTGACTCGCCCA
+CCACCGAGCAAGAGCGCGACAAGGAAGGCGTGCTGCCCCGCGCCCGCACGCTGTTTCCCA
+ACGACGCGATTCAAATCGAGAAGCTGCCTTTCGTGGACCACGACCGGCTCCTGACCCGCC
+TGAGCGACGCCCAAAAGCCCGCGCAGCAGCGTCAGGAATTGCAGGTGGTGCGCTCGCAGC
+TCACGAAGTACCGCTACCCGGTCACGGTCAACCGTGCTTCTCCGCTCGAACTCAGCGACG
+CCGAGCTGCTCGACCTTATCGAGTCGCCCACGGGCCGCATCTTCATCGCCCGGCAGATTC
+GTGAGCCCTACAGCGACAAGACGGTGCCCTACCGCATCCTCGTGACATTGGCGGAGGTGC
+AGTACGCGCCGCGTCCCCTCGCTTCGCTACGCGACGGCGACGTGACGGTGGATTTCATGC
+CGCCGCCGGTGCTTTCGATTATTTACGTAGGGCGCAGCGTGGCGGGCATCGAGGACACGC
+TGGGGCGGCTGCAACGGGTGTTCGCCATCGTGATGCTCTTCGGTGCTCTGCTCGCGGGCA
+CGCTGGCTTACGTGCTGGCGGGCCGGGCGCTGCGGCCCCTGCAAGAAGTGCGCCAGGCTG
+CCGAGCGCATCGGGGGACAGACGCTGACCGAGCGCGTGCCCGAGCCCCAGACCGGCGACG
+AGGTGCAGGCCCTCGCCCGCTCGCTCAACGCCATGCTGGGGCGGCTGGAAGCGAGTTTCG
+AGGCGCAGCGCCGCTTTACCAGTGACGCCAGCCACGAGCTGCGGACGCCCGTCACTGCCA
+TCAGCGGGCACGCGAGTTACCTGCTGCGCCGCACCAATCCCGGCGGGCAGGAGCGCGAGA
+GCCTCAACATCATCCGTTCAGAATCCGAGCGGCTGACCAACCTGATTACCAGCCTGCTGC
+AACTCGCCCGCTCCGACAGCGGGGCCCTGACCCTGAACCCCGCGCCGATTTTCTCGCGCC
+TCTTTCTGGACGACGTGAGCCGCGAACTCGCTCCGCTGGCGACCGGGGGCTCCGAGCTGC
+GGGTCAGCGGTCCCGACATTCCTTTCGAGGGCGACCCCGACCGGCTGCGGCAGGTCATTA
+TCAACTTGGTCGGCAACGCGCTCAAGGCCGGGGCCAAGACGGTCACGCTGGAGAGCAGCT
+CGCAGGAAGAGGGCCGCGAGGTCCGCCTGAGCGTGCGCGACGACGGCCCCGGCATCCCGG
+CCGAGCACCTCTCGCGTCTCTTTGACCGCTTCTACCGCGTGGAAGACAGCCGCAGCCGCG
+ACCAGGGCGGCGCGGGCCTGGGCCTGAGCATCGCGCACAGCATCGTGGACGCCCACGGCG
+GGCGCATCTGGCTGGAGAGCGAGGTCGGGCGCGGCACCGTGGCGCACGTCCAGCTCCTGG
+TGGGCGACGTGCCGGTGCTGGACGAAGACGACGTGCCGTAGGGAGACGGGGGAGAGGCAA
+CTTCCCAGCTTCTCCATTGGTACCTCTGCGCCCCCGGCCACCTTCCCCCGCCCGCGCCCG
+CCCTAGACTCGGCGGGTGCGGCGTTTTCCTGTCCTGTTTCCTCTGCTTTTGCTGCTGGCG
+CTGACGGCCTATCTGCTGCCCGCCCGGACGCCGCAGAACGTGGAGGCCCCGCCGCCCGCC
+GCCACGACGACGCTGCCACAGGCGCTCCCGACCGCCGAGCGCGAGCTGTTCGCCTCGCTG
+CGTCCGGCGGTGGTGCGGGTGGACAGCGTGAACACGGCGACGCGCACCGGGGGCCTGGGC
+ACCGGCTTTTTCATCAGCGGGGAGGGGCAGGTCCTGACCGCCTACCACGTCGTCAAGGCG
+GGGCAACTCTTCGCAGTGACGACCCTGGCGGGCAAGACCTACCCGGCGCGGGTCGCGGCT
+TTCGACGAGGCGGCGGACGTGGCCCTCTTGCAAGTCGCGCGCGGCGGCCCCTTTCCCTAC
+CTTGAACTGGCGAGCGGGACACCGCAGGTGGGCGAACGGGTGCTCGCCATCGGCAACAGC
+GGCGGCGACTTTTTGCAGCCCCGGCGTGGCGAACTGCTGCGGTTGAACGCCGAGGCGGGC
+CGCAGCGATTTCCCCGAGGGCACGCTGGAAATGAACGCGCCGCTCGCGCAGGGCGACAGT
+GGCGGGCCGATTTTCAATGAGCGCGGCGAGGTGCTCGGCGTGGTGAGTTACATCCGGGTG
+AGTGGCGACGGCGTGACGCGGGCGAGCTACGCGGTGCCGGTGCCGGGCGGCGGCGACCTC
+ATTCGCGGCCTGCAAGCGGGGGAGAGGCGCGAGTCGCCGCTGACGGCCCTCGTCGGCCTC
+GCCTTCGACCAGATGCACAGCGGCCTGACCGACCCGCCCGGCGCCGTGGTGCTGCGCGTC
+ACCCCCGGCAGCGCCGCCGCCCGCGCGGGCCTGCGCGGCTGCGTGGCCGACCGCCAGGGC
+CAGCTCACCGGCCTGGGCGACGTGATTCTCAGCATCGGCGGCGTGCGGACGCCCGACAGC
+GGCACGGCGCTCGACCAGGTCAAGCGGCTCAAGGTGGGCGACCAGGTGGACGTCGAATAC
+CTGCGCGGAGAGCAGCGGGCGCACGCCACCCTCACCCTGCGCGCGCAGCCGGTGGGCAAA
+ACACCGCTGAATGCCGAGCCCTGCACCCGTCAGTAATTAATTCAGGCGGCAAAGGTAGAG
+AATCCCACAAGCCTTTTCCTATCCACGTTTGGCGCTGACCAGGCAAAATACAGAGATGTC
+GAGAGCTTTTGTCAAGGAAGACGGCGGCGAACGCTGGACCCCACCCGCAAAGGCCGCCGA
+TTACCGGGTGGTCTTTGAGACGCTGGACGGCCCCGAGACGGTGTACGAGGCCGATGACCT
+GCTCGGCGCCCTGCGCTGGGCGGCGGCCCGCCCCGGCGCCGGCTTCGAGGTGCGCGGACG
+AGACGGGCGGCTGCTGGCCGTGAGCTGAGCAGAAATGAAGTAGGCGGGGAGCTGAACACA
+CGGCTCCCCGCCTTTCTGTTCTCTGCTCTTGCCTTACCAGTCGCCCTCCACCGTGAAGCG
+CACCGCCCCCGCCAGCGCTTGCCCCGGCTCCAGCACCCGCAGGTCCACGCCGCCGACGCC
+CCGCGCCGCGAGATTGAAAGCGTCGGTGGCGTGGCTCGTCGGCTCCAGCGCGAGGCTGCC
+GTCGGGCGCGGCGAAGACGACGAGGTGCGAAAACACGTTGTCCGCGGTCAGGGTGAGGGC
+GCGCTCGCCCCAGTCCAGCCGGGCGACGCCGTCCCACGCGGTGTACGTAGCGTCGGGCGA
+ACGCGTGCCCACCGCTGAAGGCTGGCGGAAGTCTTCCTCAGGGTTGACCGGGCGGGCTCC
+CCCCGTCGGCAGTTGCCGCTCGTCGGTGTCGTAGACGAGCGCGGCGTCAAAGTGCAGCGT
+CGGGTCCACCCCGTCCTGAATCCGCTGGAAATACGGGTGCAGGCCCATTCCAGCGGGCAT
+CGGGCGGGCGTCGGCGTTCGTCAGGGTCACGCTGATATCGCAGTGCGGCCCATGCAGGTG
+GTACTCGACCTCGGCGCTGAGGTGCCAGGGCCAGTTGAAGTCAGGAAATTCGCGGCTGTC
+GAAGGTGCAGCGCAGGTGCGCGCCCGTGACCCGCGTGACCTGCCAGGGCCGGTTCCTCAC
+GTCGCCGTGCTGGGTGAGGCCGTCTTTGGTGGTGACGCGCAGTTGAACGTCCTCGCTGCC
+GAAGGTCAAGCGGGCGTCCCGAATCCGGTTGGAAAACGGCAGCAGCGTAAAGCAAGCGCA
+CTGGCTGCTCGTTTCGACCTGTTCCAGGTCCACTGGACGCAGCACCGGGCGACCAGATGC
+GGAACGCAGATTCAGGATGCTGGCGCCGAGGTCCGGCAAAATCTCAAGTTCGAGCGCCTC
+GCTGCGGATGGTTTCGGTGCGCCGGGTCACTTGTTCCCCCCGCTCTTTCCCCGGCTGCGG
+GTCATTTCATAGAGCAGGATGCCTGCCGCCACCGAGGCGTTGAGGCTCTGGACCTGTCCG
+CGCACCGGGATGCTGACCAGCACGTCGCATTTCTCGCGCACCAATCGGCGCATCCCTTCG
+CCCTCGGCCCCGATGACGAGCGCCGCCTTGCCGGAAAAGTCGGTGCGGGTCACGTCCTGC
+GCCGCCTCGCCCGCCGCGCCGTAGACCCACACGCCGTCGGCCTTGAGCTGGTCGATGAGC
+CGGGGCAGGTTCTTGGTCTGGGCGACGGGCAGGTACGCGGTGGCCCCGGCAGCGGTTTTG
+GCGACCACCGGGGACAGGGGAGCCGAGCGGCGCTCCTCCACGACCACGCCGTGCGCGCCG
+AGCACCTCCGCCGAGCGGATGATCGCGCCGAAGTTGCGCGGGTCGGTCACGCCGTCGAGC
+AGCACCATCAGCAGCGGTGCGCCACTCGCCTCGGCGCGGTCGAGGATGTCGTCCACCGTC
+GCCCATTGCAACTCCTCGACCTCGGCCACCACGCCCTGATGCTGTGTGGTTCCGACGAGC
+TGGTCGAGTTCGATGCGCGGCAGCCAGCGCACCCGCACCCCGGCGTCGCGGGCGAGGTCC
+TGCACCTGCCGGGCAAAGGCGTCCTCGACCCCGCGCGCCAGTACCACCTCGGCCACCCGT
+CCGGCGGGCAGGGCTTCGAGCACCGGGTTTCTTCCGTAAAGCAACATGTTCAGGAGTCTA
+AGCTGCCAGGGGGGGGAGCCGGCCGAGCCGTTACTCTGTGCTCGTGAACGGTCTTGCCCT
+CAACCTGATTCTGGCGCTGGTCTGGGCACTGTTTCTGGGCGAGGTCAGCCTGCGGAGCCT
+GAGCATCGGCTTCCTGCTGGGCTTCGCGGTCCTGACCCTCTTTCACCGGGCGCTGGGCAG
+CCGCGCCTATATCCGGGCGGTGGGCGGGGCGCTGCGGCTGACGGCGTACTTCGTGGCCGA
+ACTGGTGCGGGCGAACTTCCAGATGGCGCGGCTCGCCCTGCGGCCCCACCCGCAACTTCA
+CCAGATGATCGTCGCCGTGCCGTTGCGGCTGCGCGGCGAGGGGGCGCTGACCCTGCTCGC
+CGCGCTGACGGGGCTGCTGCCAGGCACCGTCACGCTGGGCTTCTCGCCGGACCAGGGCAC
+CATGTATATCCACGCGGCGGGTCTGGAGCAGCGCAGCGCCGTGCGCCGCAGTGTGCAGGA
+AATCGAAACGCGGCTGTTGCAGATACTGGGGGAAAGGCAGGGCTCCAGCTGAAGACCCCC
+GCATGAGGAACGCGCGACGAGGTGCCCCGGAGCGGAGAGAAGCGGAAGAGAGTTTTCCAG
+CCCTAGCGCCCCTGCACCCACGTCACCAGGTCGCCCGCGCTTAGCGGCGGGGTCAGCGCG
+TAGCCCTGCGCGGCGTCGCAGCCCAGGTCACGCAGCATGTCGAGCTGGGCGTAGGTTTCG
+ACCCCCACCGCCGTGACCGTCAGGCCCAGGCTGTGCGCGAGGCTGACCGTGCCCTGCACC
+AGCTTGAGCGATTTCTGGTCGCCCGGCAGCCGGGTGGTCAGGGTGGGGTGCAGCTTGACG
+CCGTAGAGCGGAAACTGGGTCAGCGCGGTCAGGCTGCTCGCGCCGTCGCCGAAGTCGTCC
+ACGATCAGCCGGGCACCGCGCGCGCGCAGGGCGTCGAGCAGGCCCAGGGTTTCCTCGCTG
+TGGTCGAGCAGGCTGCTCGCACTCACCTCAATGTCCAGCGCACTCGGGCGGGTAATCAGC
+GGCAGCAGGCGCTCGATGGCCCCTTCGCGCCGCAGCTCTTCCAGGCTGAGGTTGACGCTG
+GTGCGCCAGTTGCGTTGCCCGGTGGCGTCGCGCAGCTGCGTGCGGCCCTGCACCGCCTCG
+CGCACCACCCATTCGCCGATGGAGGTGATGAGGTCGCTGCGCTGCGCGAGGGGCAGAAAG
+CGGGCGGGCGAGACGTTGCCGAGTTCGGGGTGTGTCCAGCGCAGCAGCGCCTCGGCGCCC
+AGCACCCGGCCGTCTTTGAGGCTGACCGCCGGCTGGTAGAGCAGCGAGAACTGCTCGTGT
+TGCAGGCCGCGGTCCAGCACCGCCCGCAACTGGTCTTCGAGCTCGAAGGTCTGGGCTTCC
+TCGGCGCGCATGTCCGGCTCGAACACCGTCAGTTGCCCGCGTCCCTGGCGCCGGGCGTGT
+TGCAGCGCCACCTCGGCGTCGGCCAGGGCTTGCTCGGGGGCCGCGGCCAGCAGCGGCGCG
+GCCCCCAGCGAAAAGGTCACCGGCACCAGCCGCTTGCCGGTCCGCAGCGGTTCGCGCAGC
+GCCGCCTGGAGCTTCTGGCCCCCCACGGCGGCCCCGAGCTGCGGCAGGTACACGGCGAAG
+GTGTCGTCGGCCAGCCGCGCCGCCTGCCCGCCTTCCAGCTCCGCGAGGTCGTTGAGCCGC
+GCCGCCACCTGAATAAGCAGCAGGTCGCCCGCCGTGCGGCTCAGCGCCGCGTTGAGGCCC
+CCGAAGCCGTCAATGTCGAGGCAGGCGACCATCCCGCCCGTTTGTGCTGCCGTGGCCTGA
+CCCAGCGCCGCGCGCAGCCCGCTGCGGTTGAGCAGGCCGGTCAGCCCGTCGTGCGAGGCG
+TCGTGGCGCAGTTTGGCCTGGGCGCGGCGCAGGGTGGTCACGTCGCGCAGCGAGAGCAGC
+AGCTCGGGCGCGGCGCTCCGGCCCGGGGAAGCGGCCGAGGAACCGGTGGACTGACCGCTC
+CCCGGCAGGGCCGAGAGGCTGATTTCCAGATGCCGGGTCACGCCGCCGGGCAACACGGCC
+AGCACCTCGCCGTTGTGCGGCAGGGTCAGCGCCGAGAGGGGGGGCACCGTCAGCGGGTTG
+CCCTGCGGGGTGTGCAGCTTGATGCCGAGTTGCTGGTGCAGGCGCGGCAGCGGCAGCCCG
+GTCAGGGCGATGTTGTGGGGGTCGAAGCCCAGCAGCCGCGCCGCCGGCTCACTGATGAGC
+TGCACCCGGCCCTGCGGGTCGAGCAGTATGGTGGCCGCGCCGCTCAGGTGCAGCAGCCGC
+GCCGCGCCGTTGTCCTCGCTCACCGCGGCGGGTCGGACACCCTCGGCGAGCAGCAGCCCC
+GGCACGGTGTCGCTGCGGCGCACCAGCAGCGGCAGTTGCCCGCCGCGCGCCAGTGCAATC
+TCGCTCGGCACCGGGCTGGGCCGCCCCGCCTCTGCGCTCTGAATGAGGTCCTGAAGCAGC
+CGCGCGCCCGCCGGAGCCCAGCAGGGCCACTCGTGCAGGGGCCGCTGGGGGTGAGCCTGG
+GCTTCGGCGAGGTCTTCGGGTTCCCCCAGCAGTTGACGCATCCCCCGGCTCGCCCCCTGC
+ACCGCGCCGCCCGGTCCCAGCAGCGCCAGCGGCAAGTCGGTGCCGAGCAGCGCGGCGAAC
+TGGGTCGTCTGGGTGTGCTCGGTGCTCACGTCCTGCACGGTCCACAGCACGCCCGCCGCC
+GCGCCGCCGAAGTAAGGCCGCGCCGACCCACGCAGCCAGCGCTCCCCGCTGTGCCCCGGC
+AGGGACGGCACCCGCTCGTCGCCGAGTTGCACGGCCCGCCCAGCCGCCGCGCTGTCGAGC
+TGCTGCGCGAGCGCCGCGTGGTCGGGAAAAACCTCGTGGACGGTGCGGCCCAGCACATCC
+GCCCCGGTCAGCCCGAACAGTTCCAGAAAGGTGCGGCTGACCTGTCGGAACTCCAGCTCG
+GCGCTCAGCCACGCCGTTGCGGCGGGAAGCTGGGTGATCAGCATGTCGGCCTCGCGGCTC
+GCCCCCTCGGCACTCGCCGCCGAGAGCAGCAGCGTGAGCACCTGCACCGCGCCGTCGGGC
+ACCGGCGCCCCGTCGGACCACAGCAGTCCCAGCAGCGCTCCGTCGCGCGTGATCCAGGCG
+AGGTCGCCGTGTTCGAGCCAGTCGTCGGGCGGCACCAGTTGCGCTTCCTCGGTGGGCGCG
+CCCTCGGCCTGAATGTTCAAAATCCGTTGCCCGATGGCGGCCAGCAGGGTGGCCTGCGGA
+GCGTGCAGCCGGATCAGGTCACGCAGGGCAATGGGCAACGCGGCATGGGCATCGGTCGGG
+GCAGCGGGCATGGGGTTCAACCTCGGAAAAAGCGGGAAGCGGGAGAAACGGGCGCGTCGG
+GGCGCCTTGAAATGAACTGCTGTTCTGAGCTTGCCACGTCGCCTCTTACGGTCTTCATGC
+AAGCCAAAGAAATAGGAGGAAACTTGCTGCTGGGCGCTTAGAGCATTGGATACAAAAAGA
+CCCCCTCACCCCTTGCTTCGCAAGGCCCTCTCCCACCAGGGTAGAGGGTCAAAAATCCAA
+AGCATTCTTATGTCGAACACTCTAGGGACACCCATCGATCAACAGCAAAAGGCCCACCGC
+CGCGTGTGCAGGGTGGGCCTTCTGAGGAGAGGAGAATTCAGGCGCTCGGTTTGTCCGACT
+TGTCCTCGGCGGCGCTCTCTTCTTCGGTGCTGAGCGAAGCCTCTTCGATGGAGATACTCG
+CCATCAAGACCACCTTGTCACCGTCCTGCTCGACCTCGACCTTGGAGTTGCCCGAGGGGA
+AGTACTTTTGGACGACTTCCAGCAGGTCGTTGCGCAGGGCCTCGACCTTGCCGGGCGCGA
+TCTTGGCGCGGTCATAGGCGAGCACCAGTTCGAGGCGGTCCTTGAGCGTTTCCTTGGAGC
+GGCGTCCCTTGAACCAACCGAACATCAGCTCCCACCCCCGAACAGGCGGCGAATGGCGGC
+CCAGATGCCTTTTTCTTCCTCGGTCAGCTTGGGAAAGGGCACGTCCTGACCCTGAATGCG
+CTGCGCGGTCGCCATGAAGGCGTCGCCCGCCTTGGTCTTGCCGAGCACCGCCGGCTCACC
+GACGTTGGTCGAGACGATGATGCCCTCGTCCTCAGGCACGATTCCGATGGGCTTGACGCC
+CAGGATGTCCACCATGTCGTCGATGGAGAGCATGTTGCCGCTCGCCACCATCTTGGGACG
+CAGGCGGTTGACGACCAGCCGAATCTCGGTGATCTGCTGCGCTTCGAGCAGGCCGATGAT
+GCGGTCGGCGTCGCGCACCGACGACACTTCGGGGTTCACGACCACCAGGGCGCCCTCGGC
+GGGGGCGGCGGCGGTGCGGAAGCCCGACTCGATCCCGGCGGGCGAGTCGATCAGCACGCG
+GTCGAAGCCCTCTTCTTCCAGCAGGCCCTTGACGACTTCCTTGAAGACCTCGGGGTCCAG
+GGCGTCCTTGTCGCGGGTCTGCGAGGCGGGCAGCAGGTGCAGGTTCTCCACGCGCTTGTC
+GCGGATCAGTGCCTGATTCATGCGGCACTTGCCTTCCAGCACGTCCACCAAATCGAACAC
+CACGCGGGACTCTAAGCCCATCACCACGTCCAGGTTCCGCAAACCCACGTCCACGTCGAT
+CACAACGACTTTTTCACCCAGTCGGGCCAGGGCCGCGCCGATGTTGGCGGTGGTCGTGGT
+CTTGCCCACGCCCCCCTTGCCCGACGTGACGACAATCACTTTGGCATCCATGCTTGGCGC
+AGCATAGCAAGGCAACGTGAAAATGTAAGCCTGTGGGGGTGGAGGCCGGGGGAGGGGTTG
+CGGCAGGTGTGCCGGGTGGGGACAGCGGCCCCGAATGCAGGCGCCGGGAAGCCGGTAGAC
+TGCCGGGCAGCATGACCCGACTTTCCGGAAACAATCAGAACCGCAGCGTCCTGATCATCG
+GCACCCTGGTCGCCGCCGCGCTGATCGCCCTCGCCCTGTTCGCCGTGCGCGGCAAGAGCA
+CGACCACGACTGGCGAGGCGCAGACCTTCACCTACGCCAACTTGCCCTACGCGGGGCAGG
+CGAACGCGCCGGTCAACGTACTGGTCGTCGAGGACTTCAAGTGCCCCAACTGCAAGTCCT
+TCGAGGAAACGGTGGCGCCCGAACTGCGGACCAAATACGTGGGGACCGGCAAGGTCAAGA
+TGTACTCGCTGGTCTACCCCTTCCTCGCCGACCGTCTACCCGAAGACGACAGCAAGTACG
+CCGCCCAGGCCGCCCGCTGCGTCTACGCTCAGGGCAAGAACGACGCTTTCAATACCTACA
+AGGAAATCCTGTTCCGCGCCCAGGGCCCGGAAACCGAAGTCTGGGCCACCAAGTCGCGCC
+TGAAGGAGCTGGCGACCAGCCTCGATATCGACCAGGCCAAGTTCGCCACTTGCCTCGACA
+ACGACGAAACCGCCGCGCAGGTCGAGACCGACAAGCAAGAAGCCCTCAAGGCGGGCGTGG
+GCGGCACCCCCACCGTCTTCGTCAACGGCAAGCTGGTGAATGTCCAGAGCGATTACGTCA
+AGGACATCTCGGCGGCCATCGACGAAGCCCTCAAGCCGTGAGCAGCGGGGCATGAACCGC
+GACACCCGGTTGTACCTGGCCTGGTTGGTGGCCCTCGCCGCCACCCTTGGCAGCCTGTAT
+TTCAGTGAGATTCGGCACTTCAACCCCTGCCCGCTGTGCTGGGCGCAGCGCATCTTCATG
+TACCCGCTGGCCGTCATTCTGGGCATCGCGGCGTTTGTGGGCGACCACGGCGTGCGGCGC
+TACGTGCTGCCGCTGGCGGCGCTGGGGCTGGGCTTCGCCATCTTCCAGAACCTCGAAACC
+TGGGGTTTCGTTCAGTCCATCAAGGCGTGCACCGTCAACGCTGCCGCTGCCTGCAACACC
+CCCTGGCCGGTGTGGGGAACCAGCCAGGACACGCTGAACCGTGCGCTCACCATCCCGGTG
+CTGAGCATGATCGCCTTTGCGCTGATTCTGGCGCTGCTGAGCTGGCCCCGGCAGCGCGTG
+ACCGTGCCCGAAAGCGCGGCAGTCCAGGGCTAAAGTTGCAACTCGAGCGCCCGGCCCCCT
+ATACTTCTCCGGCCCGGTTTGCCTGCCAGCGTGCAGCGCGAGCCTGAAAAGGAGTACGAA
+CGTTTCTGCCCGTGAAGAGCGGGACCTCGGAGACGGTCCGCTGCCCGAAGGAGACCCCCC
+ATGCAGACCCACATCAAGATCAACCGCGGCGAGCTGCTGCGCGGCATCGAGCAGGACCAC
+ACCCGCCAGCTTCCCGACTTCCGCCCCGGCGACACCGTGCGCGTGGACACCAAGGTGCGC
+GAAGGCAACCGCACCCGCAGCCAGGCCTTTGAAGGCGTCGTCATCGCCATCAACGGCTCG
+GGCAGCCGCAAGAGCTTTACCGTGCGCAAGATTTCGTTCGGTGAAGGTGTGGAGCGCGTG
+TTCCCCTTCGCTAGCCCCCTGGTCAATCAGGTGACCATCGTGGAACGCGGCAAGGTCCGC
+CGCGCCAAGCTGTACTACCTGCGCGAACTGCGCGGCAAGGCCGCCCGCATCAAGAGCGAC
+CGCAGCCGCGTGATGAAAGACGCCGCCCGCGCCCAGCAGGACAAGGCGAACGCCAGCGCC
+AGCCAGGCCGCTGCGGCTCAGGCCGACGTGACCGTCATCAGCGCCGCTCCCGAAGTGGCC
+CCCGAAACCCAGGGCGAATAAGTCCAGGGCTCCCAAGCCCGCCTGCCTCCGCGTGAGGTG
+GGCGGGTTTCTTTTGGCTGTGGGGTGGGCGTTTACAGGTAAGCCAGTTCCCAGTCCTTGG
+CCCCGTGCGCCAGCCCTGCTCGCAGCAGCGCGAGGCCACTCGGCGCCGGGTCGCGCCAGT
+GGGGGAGGCCACTCAACTCAGCCTCGAACTCGGCCAGCGGGCGGCGGGCGACGGGCTGCA
+CGGTGTCTGTTACGGTGCCTGCGCTGACCTCATAGACCGCGCTATACACGTTGCCTTTGC
+GGGCGTCGAGGCTCACCGCCTGCGGGCCGTCGCCGCGCACCAGACTTTCCAGGGTGGACA
+CGCCGCGCACTTCGGCGCCCCACACGCGGGCGAGCCCCAGCGCGTAACTCGCGCCGACGC
+GCACGCCGGTATAGGAGCCGGGGCCGGTGCCGATAACGATGGTCTGGGCCTGAAACGGCA
+GCCCCGCCGCCCCGAACAGGGCACGGGTCTCGTCGGCCAGCCGCTCGGCGCTCGCCCGCC
+CGACCTCCTGCACCCGCTCCAGCTCGCCGCCGGGCCAGCTCACGGCCAGCGTGAGGAAGG
+GGGTGGCGGTGTCCAGGGCGAGGGTCACAGAAAGAGGGGTGACAGGGGCGGCGGAGACGG
+TCATCGGGCGTATTAAAGCAGAGGCCGGGGCAGGCGCCCGTGTGCCCTGCCCGCTCTCAT
+CTCTTTGTCACCCCGGCAGGGACGTTTGACCGCCCCTTTTTCGCCCCCTGGAAGAAGGGC
+AGGTGTTATCCTCTGCTCACTATGTCGAACATTGCCAAAGGGCTTGAAGGTGTTCTCTTT
+ACCGAGAGCAAGCTGACGTTTATCAACGGCTCGGAGGGCATTCTGACCCACCTGGGCATT
+CCGATTCAGGAATGGGCCGAAAAGAGCACCTTCGAGGAACTCAGCCTCGCGCTGCTCGAC
+GCCAAACTGCCCACCGCCGAGGAACTCGCCAAGTTCGACGCCGAACTCAAGGCCAACCGC
+GCCATCCCCGATCAGCTCGTGGGCATCATCCGCGACATGCCCAAGGGCGTACACCCCATG
+CAGGCGCTGCGCACGGCGGTCAGCTACCTGGGCCTGCTCGACCCTCAGGCCGAGGACATC
+ACCCCTGAGGCCCGGCGCGCCATCAGCACCCGCATGATCGCGCAGTTCTCGACCATCATC
+GCGGCGATCAACCGCGCCCAAGAAGGCCAGGACATCGTGGCCCCCCGCGCCGACCTGACC
+CACGCGGGCAACTTCCTGTACATGCTGACCGGCAACGAGCCCACCCCCGAGCAGGCCCGT
+CTGTTCGACATCGCGCTCGTGCTGCACGCCGACCACGGCATGAACGCCTCGACCTTCACG
+GCGATTGCGACCAGCTCGACCCTCAGCGACATGTACTCCTGCATGGTGAGCGCCATCGGC
+GCGCTCAAAGGCCCGCTGCACGGCGGCGCCAACGAAGCCGTGATGACCATGCTCGACGAA
+ATCGGCACCGTGGACAAGGCCGAGGCGTACATCACGGGGAAGCTCGACAACAAAGAGAAG
+ATCATGGGCGTGGGCCACCGCGTCTACAAGTACTTCGACCCCCGCTCGCGCGTGCTGCGC
+GACTACGCCGAGCACGTCGCCAACAAAGAAGGCAAGAGCAACTACTACCAGATCCTCGAA
+GCCATCGAGAAGATCATCGTGGACCGCATGGGCGCCAAGGGCATCTACCCCAACGTGGAC
+TTCTACTCCGGCACCGTGTACAGCGACCTGGGCATCAAGAAGGAATACTTCACCCCCATC
+TTTGCCCTGGCCCGCATCAGCGGCTGGTGCGCCAGCGTCATCGAGTACAGCCAGGACAAC
+CGCCTGCTGCGCCCCGACGCCGAGTACACCGGCGCCCGCGACCAGCACTACGTGGACATC
+AAAGACCGCCAGTAAGCGGAGAAGGTAAGAAAGGGGGCCGGAGCATGGCGCTGCGGCCCT
+TTTTCTTTGCTGCCTGTTTCGCTTTACAGCAGCCTGCCACCATCATGCGCTTCGGGCGTC
+TGCACCGGCACCCCCCGCGCATTCAGGGCCTCGCGCAGCATGGGGATGTTTTTGAGGGCA
+TGCCCGCCAGTCGTGTTCTGGAAAAACACGTACAGCTCGGAGAGGTCACCGGCGACTGCC
+GCAATTTTCTCGGCCCATTCGTCCATCTCGGCGCGGTTGTAGAGGTAATCGTGGCGCTCG
+CCCGCGCTCTGGCCTTCCCACCAGGTTTCGCGGTTGCGCCCGTGCAGGCGCAGGTAGCCC
+ACGTCGCCGGTTACGTGGACCTGGGGTTCGGGCATCCCACCCACTGGCGGGTAATCCGGG
+CTGACCCAGATGATGCCGAATTCGCCCATGCCCTCGCGGACTTCGGGTTTGTCCCAGCTC
+GCGTGCCGCAGTTCCACCGCGAGTTCGTGCCCAGCAAAGCGCTCGGTGAGCAGCGCCAGA
+TACTTGCGGTTGGCGGCGGTGCGGTGAAACGAGTAGGGAAACTGCGCCAGATACGGCCCC
+ATCATGCCGGCCTCGCGCAGTGGCTCGGGGCTCTGGAGCATTCGGTCAAAGTCGGTGTCG
+GTGGGAGCGCGTACGTGGGTAAAGACCTTGTTCAACTTGACGGCGAAGCGCACCCACCCG
+CCCGATTTGCGGACCATGCCTTCAAAGGCCTTGAGGCCGGGAATCGCGTAGAACGATGAA
+TTGAGCTCCACCGCGTCGAAGTGGTGGGCGTAGGTCTCCAGAAAGGCGTCTTTCTTGACG
+CCCTCGTAAATCAGGCCCGGAGCCGTCCAGTCCTCGTCGGTGTAGCCGCCGCAGCCGATG
+TAGACGCGCATGGGGGAGAGGGTAGCGGGTGGGCGTGGGAAACATATTTACAGTCCGCAG
+AGAATCCCAGCAGAGACTTGGAACTCCAGTAGCTCTCAGGGCAAGCAGGAGCAGGCGCTG
+CCTTGCATTGGCGTCCTGCGCCCTGAACGTCTGACCCCGTTCCGCCTACAATCTCCCCCG
+TGACCCGCTCCGTCAGCCACCCGCCCTACGCCGACCCCTTCGCCCACCCGCCCGAGACTT
+CGCCACAGGAACTGACCGCCCAGCTGACTCCCGGCGCCCGTTTTCAGGACGTGCGCTTTG
+AGAACTACCGGCCCAACCCGGAGTTTCCCAGTCAGGCGCAGGCGCGCGACCAGCTTGCGG
+AATTCGTGCGGCAGGCGGGGCAAAAGGCGAGCGGCGGGGGCTTCTGGCCCTTCAAGCGGA
+GGGCCCCGGAAGGGCGCGGATTTTACCTCGACGGCGGCTTCGGCGTGGGCAAAACGCACC
+TGCTGGCGAGCGCTTACCACGCGGCCAAAGGGCAGTCTGGGGGCAGCGGGGGCGACGTGG
+CCTTCATGTCGTTTCAGGACCTGATGTACCTGATCGGGGCGCTGGGGATGCCGCAGGCCA
+TCGAGACTTTCCGGAACTACAAGCTGCTGCTGATCGACGAATTTGAACTCGACGACCCCG
+GCAACACCCACATGGCGAACACCTTTCTGGGCGGGCTGATGCCGAGCGGCGTGAGCGTGG
+TGGCGACCTCCAACACCGAGCCGGGGGCGCTAGGCGCAGGGCGCTTCAATGCCGAGGATT
+TTCAGCGGCAGATTCAGGGGATCGCCGACCGCTTCGGGCCGCACCGGATAGACGGCCCCG
+ACTACCGCCAGCGCGGCACCGAGCCCGCCCAGCCGCTCAGCGAGGCCGAGTTCGCGGCGT
+GGCTCGCGCGCCAGAACCCGCAGACGACGGCGCTGATGACGCACGCCGAACTCAACCGCG
+CTCTGCTGAGCGTGCACCCGAGCCGCTTTGCCCGCGTGCTGGAGCAGGTGAGCGGCGTAG
+CGGTGACGAACCTGGAACCGATGCCCGAGCAGGGAGAAGCGCTGCGCTTCGTGCATTTCG
+TGGACAAGGTGTACGACCTCGGGCTGAGCGCCGCGTTTACCGGGGTGCCGCTCAATGCCC
+TGTTTGACGACATCTACCGCAACGGCGGCTACGCCAAGAAGTACAGCCGGGCGCTGAGCC
+GCCTCTCGGAAATGCTGCGGGAGGCGCGGGGGTAAGGGACTTTTCCCTGTCCTCCAGCTC
+CCATGTTTCGCCGTGACCCCCTCATGGCCCAGTGGCGCGCCGTGGCCCGCTTGCTTGAAC
+TGGACGACGCGCAGGCCCGCGCCCTGCTGGGGCTGGTGCGGCAAACCTTGCGGCGCGGCG
+GGGTGCTCGGCGTAGCGCGGGGAGACGAGCGGCAGCTGCTGACCTTCGGCGGCGTACCGG
+AAAATGGCGTCTTTGAGCTGGCGAGCGTGACCAAGCCCTTCACGGCGGCCCTCGCCTCGG
+CGCTGGTGCGCGATGGGCGGCTGGACTGGAACGCGCCCCTCGCCGCGCTCGGCGGGCCGC
+TGCGCCGCTTGCCCCGCGCGCTGACGCCTTATGCGCTGGCGACCCACACGGCGGGGCTGC
+CTCCGCAACCGGCGCGGGCTGCGCTGACCACCTTCACCCGGTTTGCCGACCCCTACGGCG
+GCATGTCACCGGCGGACGTGCTGGCGAGTGCCCGCCGCTGGGCCAATCCGGGGCAGGCGG
+GGCGCTTCGGATACTCCAACCTCGGCGCGGGGGTGCTGGCGCTGGGGCTGGCGCACGCGG
+CGGGGGAGGAGACGTCGGCAGCGGGCTATAAGCGGGCGCTGCGTCGCCTGGTCACCTTTC
+CACTCGGACTGCCGGGCGTGGGTCTGACCCCGGCGCGGGATGTCGTGCCGCCTTACGGTC
+TGCTCGGCGGGCAGGCGGTGACGGGCTTTGCCGAACTCGCGGGCGCGGGGGGCCTGTTCG
+GGAGCGCGGCGGAGTTGCTGCACTTCGGCGAGGCGCACCTGAGCGGGGCAGCAGGGCAGC
+ACTGGCGGCAGGCGCAGGCTTTTCCCGGCTTGCCGCCGCTCTACGCCGGGGCCGCGCCGG
+GGTGGTTTCAATCGGGGAGCACCGTCTGGCACGACGGCATTGCCCGTGGCACCCGCACGG
+CGCTCGGGTTCTCGCCGCGATCCGGCGCGGTGGTCACGCTGCTGGTGCGCGGAGCGGTGC
+CGCTGGTGGGGGTGCGGGCGGGGGTACCGCTTTTGCTGCTCGGGTTGCTGGGCGGGACAG
+ACCGTTAGAGCATTTGACAGAATGATCAGATCTGTCTTTGACCCTCTACCAAGGGGAGAA
+TTGTCAAGCTGCGAAGTAGAGGGCCTTGCGGAGCAAGGGGTGAGGGGTCTTCACGTCCAG
+TCCTGCGCGAACTGCTCCCAACTCGCCGTGTCGCGGGGGCACCCGCCCGTCTCCGTCCAT
+TCCCAGTAGGGGGTGTAGAGGCTGCGGGCGGTGACCAGCTCATCGCGGAAAATCCGGGCG
+CTGAGGCCGGTGTCCAGCAAACCGCTCGTTTCAAAGCGCTGAAGCACGCCGCTGCGGTCG
+TAGGGCACCCGGCGCAGCTCGGTCTGCCAGCCCTGCGGCGTGGCGGTGAGCAGCAGGTAC
+TGCGCGCGGGGGTCGCCGTCCGCCGGAGAACCGACGGCCCCGGTGTTCAGCACCCTCACG
+CCGCCCACCAGCGCGTCGGCCTGGCGGTGGATGTGCGAGCCCACCAGCACGCCCGCGCCC
+GACTCGTCGGCAATGCGGCGAACCAGCGCGGGGTCGGTGCGTTCGCTCAGGCCCCGGCGG
+TAGTCGTCGGGGGTGCCGTGCGCGAGCAGCACGTCGGGCAGGCCGGGCACGCTCAGCCGC
+GCGGTCAGCGGCCAGTCTCCCGGTACGTCGAGCAGCCCTGCCGCGTGCAGTTGCTCGGTG
+CTCCAGGCCGTCGCGCCCCAGAAGGGGTCGTCGTACCAGTCCTGCGGCAATTTATCGCTG
+CGCGTGTGCCACAGCCGCAGCAGGTCGTCGTGGTTACCGAGGACAAACGACGTGTCGTCG
+CGGGCGAGCAGTTCTTCCATCACCTGCACCGAATCCGGCCCCCGGTTCACCACGTCGCCG
+TTGACGATCAGCCGCTCGGCGCCCTGCTCCGCCGCGTCTTTCAGCACGGCCCGCAGGGCG
+TCGGCGTTTCCGTGGATGTCGGCCAGCACAGCAATTCTCACGGGGGCATTGTAGGCGCCG
+CTTCCGAAGAAAATACTGAAGAAAACCCCATACCCGTTCAGGCCCCGTTTGTGGTTACAG
+TAGGGCCATGAAGCCACTGAAGATGCTGACTGTTGTTCTGCTGGGTGCTGGAACGTTCGC
+TTCGGCGGCTTCGGTGACTTCGGCGGTCAAGACCGAGATCAACCAGCTCGCCCGCCAATA
+CACGGGCCGCCCGTGCCTGAGCAATGGCGAATACGGCCTGGACACCGAGCCTTTTGGCCG
+CAAGGTGTCGCCGAGCGAGCTGAGGACGGCGCGGGATATCCTGTACCGTCAGTTGCTGGA
+AGGTTTCGACCAGAGTGCACGCAAAAACCACTTCACCTACGAGGTGCGCTACAACCAGAA
+CCGCGTCTGGGTCTGGGCCAAAGCCCCCAACTCCTCCCGGCAATATTTCACCTTCGCGAC
+CCTCAGCCCGACCGGCATTCGAATGGTGAGCTGCCTACAGTAAGCGGACAAGAAGAAACA
+GGCCCCTTCCCGCTGTGGAGGGGGCCTTTTGCTGTTTAAGGTTGCCGAATCCAGTACCGC
+CGAATGGGCTGGTCATGATACTGGGGCACCTCAAATTCCCCTTCCAGTTCGCCGCCGTTC
+GCCTCAATGACGCCGCGTGAGCCGAAGTTGTCCACATCGCAGGTGACCAGCACCGGGTCT
+ATCCCCAGTTCGCGCGCCCGCTCCAGCGCCAGCCGCAGAATCAGGGTGCCGTAGCCTTTG
+CGCCGCGCGCTGGGGCGGATTTCGTAGCCGATGTGGCCGCCGAACTCACGCAGGCGGTCG
+TTGAGGCTGTAACGGATAGAGACGCGTCCCAGGTACTCGCTCCCCTCCACCAGCCAGCGG
+TATTCGGAGTGGACAAAGCCCTCCGGCAACTCGTTGCCCGGTTCGTAACGGGTCAGGTCG
+CGCAGGACTTTGCCGAAGTCGGCGCTGATGTCGTCGAGCTTCCAGACCAGCGTCTCGCCC
+AGGCCACTGCCGGTTTCCTGTGCCTCGCGCACGGCGGCGAGGAAGCTGTCTTTGTACTGT
+TCGGAGGGGCGTACGAGGTGTGGCATGGGTCAGGGTAAAGGTTGGCGGTGGCCTGGGCAT
+CGGCCACCCGGCCTACCCTCACCCACCAACCGGGTTGGTCAATCTGTCCCGAAATGGCGT
+CCGCAGCCCCATAAAGCGGCGGGTGGGGGGCGTACAATCCGGGATGTGAAAGAAGCGGCC
+TTCGACGTGCTTGACCTCGGCCTGCTGCCCTACCCGCAGGCGTGGGCGCGGCAGAAGCAG
+GAACTGGCCCGCGTGGCGGTGGGCGGGCGGCCCACGCTGCTGCTGGTGGAGCACCCCGCC
+GTGCTGACGCTGGGGCGCAAGGCGCAGGAGGGCGAGAACATCGTGGTCACGCGCGAGTAT
+CTGGCTGCGCAGGGCATCGACGTGTTCGCGGTGGAGCGCGGCGGCGACGTGACCTACCAC
+GGCCCCGGCCAGCTCGTCGCCTACGCCATTTTTCCAGTCGGGCGCCGGGTGCGCGACTTC
+CTGCGGCTGCTGGAAAACGCAGTGGTGACGGCGCTGGGCACCCTCGGCCTGCCCGATGCC
+CGGCCCAATCCCGGCTACGCGGGCGTGTACGTGGACCCGCGCGAGATCAACGGCAAGACC
+TACGACCAGAAAATCTGCTCCATCGGCGTGGCCATCAAGCAGAATGTCGCCCTGCACGGC
+ATCGGCCTGAACGTCTGCACCAATCTGGACCACTTCGACCTGATCGTGCCCTGCGGCCTG
+ACGGATACCCAGATGACCAGCGTGCAGCGTGAGTACGACCTGCGCGGTCTGGGCAGCGTC
+AGCATGGAGCAGGCGAAAAAGGCGCTGACCGACGCTTTCGCCTTGACCTTTGCCGACTAT
+GATTGGAGCCTTCCGGGGGTGGCCGCCGGGCAGGAGGCGCTCTCTGTGGCCTCTCCCTAG
+CCTCCTTGACCAGCCGTCACCCTCCAGCGACCCTTTCCAACCGAGGAAACCGAAATGACC
+CAGCAAGACCCGTCCACCAAGGAACCTAAATTCATCAAAAACGGCATCTACCGCAAGGAC
+AGCGTGCCGGTGCGCGAGAAGAAACCTGAGTGGCTGAAAGTCACCATCCCCACCGGGCAG
+GTGTTTACCGAAGTCCGCAAAATCGTGAAGGAGCACCGCCTGCATACGGTGTGCGAGGAA
+GCGATGTGCCCCAACATCGGCGAGTGCTGGTCGCGTGGGACGGCGACGTTCATGCTGATG
+GGCCACATCTGCACCCGCGCCTGCCGCTTTTGCGCGGTGGACACTGGCAACCCGATGGGC
+AAACTGGACCTCGACGAGCCGCGCAGCGTGGCCGACTCGGTGCGGCTGATGGACCTGAAG
+TACGTGGTGCTGACCTCGGTGGACCGCGATGACCTGCCCGACGGCGGCGCCTACCACTTC
+GCCAAGACGGTGAAGGCCATCAAAGAGGTCAATCCGCAGACCCGCGTGGAAGCGCTGACG
+CCCGACTTCGGCGGCAACACGGCCTGCGTGGACCTCGTGCTGGACAGCGGCGTGGATACC
+TACGCCCAGAACCTCGAAACCGTGCGGCGCCTGACCCACCCGGTGCGCGACATTCGCGCG
+AGCTACGACCGCACCCTGAGCGTGCTGGCCCACGCCAAGCAGGCCCGCCCCGACGTGATT
+ACCAAGACGAGCCTCATGCTGGGCCTGGGCGAAACCCGCGAGGAAATCCGCGAGGCGATG
+GCTGATTGCCGCGCCGCCGGGGTGGACGTGCTCACCTTCGGGCAGTACCTGCGCCCCACC
+ATGCACCATCTACCGGTGGAACGCTACATTTCGCCCGCCGAGTTCGACGAAATCCGCGAA
+GAAGGCATGCAACTTGGTTTCCTGGAAGTCGTCTCCGGTCCGCTGGTGCGCTCGTCGTAC
+AAGGCTGAGCAGATCGTGATGGACCGGCCCGGCAACCTGCCCGAGCACCTGAGCCACTTA
+GACGGCGGCAGCGAATTGACCTTGATTTGAGATTGAGTGGGAAAGGGGCCGGGGCCATGC
+GCTCTGGCCTTTATTCTTTGGGTCGGTACTTGGCTTCGAGGCTCCACCAAAAGTCGGACG
+CGCCGCTGCCTACCGTCCGTTACCCTGACCTCAATGTCAAAATTCCGGCGAATACTGCTG
+CCCCTGGCGCTGCTGGCTGCCCTGGCTCCAGCACAGGCGGCCCCACCTACGAGCTATCAG
+GGGCCGGTGTACGGCGCTGGCGTGCCGAACGTCAAGGTGGTTCGCCCTCTCTGGACGTTG
+ACGGTAGATAAGGCCGAGTACGGCGACAGGGCCGTGCTGCTCGCTGAAAACCGCGTGCTG
+GTGAAGGTGGGCGGGGCGTTGCAAGCCCGCGACGTGGCGACGGGCCGCGTGCGGTGGACG
+CTGCGGCAGCCGGGAAACCTGGGACTGGCCGACAAAAACGCTGTCTTTCTCACGTCCGGC
+CCCACCCTGAGCGCTTACCGGCTCAGCGACGGGCGGCGCCTGTGGACCCGCGACCTGGGC
+GGCGCGGTGCGCGATGTGGGCGAGTCGGGCGGCGTGCTGTACGCGACGACGGAACACGGC
+GGCATAGCCCTGAGCGCCGCGACGGGTCAGACACGCTGGGCCTTTAAAGAGCACGAAATG
+ACGGGCTTCCGGACGGTTCTGGGCGACACAGGGTCAGGGGGCGTGGTGTTCTGGGACGCT
+TACCAGGGCGAGCCGCATTTTCCGGCCACCTACGCCTTTGACGCGGCGACGGGCAAACAG
+CTCTACCGCCTCGGCGGCACGACGGGGCCGCTGGGCGTGCGCGGCAAGGCGGTCCTGATG
+GCCGACACGAGCTTTATAGGAAGCGATGACAATGCCACCCTGACCTGGGTAAACCTGCGT
+TCCGGCGTCACTGAACAGGTCTTGAAGCTGGCCGCCGATTTCCGCTGCCCTGGCAGAGGC
+ACCCTGGAGCGCCGCACGTCCGAAACCTTCTCTGCCCCGCCGCACATTTATGTCAATGAC
+CAGTGCGGCACGCGGCTGCGGCAGTTCTGGGCGAATGACCCGGCGCTGGCTGGAAAAACG
+CCGTCCACGCCGCTGCCACCCGCCCGCACCTTCGCCGTGCCGGACGACGGTCGCTTTCGC
+CTGGGGCCAGTGGGGGAACTGTTGGTGTTTGAAAGCCGCATGGGAGAAGTGCGCTTGATT
+CCAACCACGGGCCGCGCGCCTATCAACTACAACGGGGTGGATATGCCGACCGGGACGGGC
+CTTGTCCTGCCGGGAGCGGGGCCGGTGTCGCGGTTGGACGCCCTGGGGAGCGTGCTGTAT
+GTCGGGCGAGTGAATGGTGAGTTTCTCGCCTACGACGCCGCGAAGAAAAAGCCCCTCTAC
+GCGGCGCAGCTTCCCTGGCGCGGCTTCGGGCCGACCTTCCGCAGTGGCAAGTACGCGGTG
+CTGACCACTCCCGGCGCACTGGCTGTGGTGCGCGAGCCCTGAAAACGCTGGTGGTCGGCG
+GCACCGGCATGCTGCTGGGACTGGTGCGCGAGCTCCTCGCGGCGGACGACGAGGTGTGGA
+CGCTGGCCCGCCACGCCCCGGCGCTTACGCACCCGCGCCTGCATCCCCTGCTGGCGGACT
+ACCGCGACGCAGCGGCCTTGCGCGCGGCCCTGGCCTCCGCCACGCCGTTTGACCGGGCGG
+TGGTCTGGATTCACTCTGCGGCGCCGGACGCGCCCTTCGTGGTGGCCGAAGCGGTGCGCG
+GGCCGTTTTTTCACGTCCTGGGCAGCGCGGTGGCCGACCCGTCCAGACCCGACGACGGGC
+GGCGGGCCCGTTTCGCCGCGCTGGGCACCGATGCGCGTGACGTAGTGCTGGGCTTCGTGC
+GGGAAGGCGAACACTCACGCTGGCTGACGAACGCGGAAATCTCGGCGGGGGTCTGGGAGG
+CTGTGCAGGGTAATGTTCAGCGGGCAGTGGTGGGAACGGTGACGCCGTGGGCCGCGCGGC
+CCGGCTGACCGGCGTGTTCCTGCTAGCCTCGCCTCATGCTTGACCCCCGTTCTGTTCCTT
+TTGCCGCTCAGATTCACCCCCAGGCCCGCCCGGCGCGGCGGCTGACCTGGGACTCGCGCG
+AGGCGGGGCCGGACACGGCGTTCGTCGCGCTGCCCGGCGAGAAGATGCACGGCAACAGGT
+TCGTCGAGCGGGCGCTCGCGGCGGGGGCGCCCTTCGTCCTGACCGACCTCGACGTGCCCC
+GCGCCGTGCGGGTAGATGATGCGCGGGGGGCCCTGTTCGCCTGGGCGCGGAGTGAACGGG
+CGAAAAACCCGCTGGTGGTGGGCATCACCGGCAGCGCGGGCAAGACGACCGCCAAGAGTT
+ACGCGGCGGCGGCCCTGGACGCCCACTTCATGCCGGTGTTCAACACCATGCCCGCCATCG
+CCTGTTTTCTGGTGCAGTACGGCGCGAGCCAAAAGCCGCTGGTGGTGGAGATGGGCATCG
+ACCACATCGGCGAAATGGCCGAGCTGATGGACCTCGTGCGGCCCGATGTGGGCGTCGTGA
+CGACCATAGGCCCGGCGCATCTGGAGCAGTTCGGCATGGTGGAGACCATCGCCCACGAAA
+AGGGTCAGATTCTGACGGCGCGGCGGGCATTGGTCGGCTCGCAGGCCGCCGCCTTTTTCC
+CCAAGGCCCAGTTTCCCCACGTGGACAGCTACGGCTTCGGCGACGTGACGTTCCGGGGCG
+AGGGGCTGGAACTCTCGCCGCAGGCCGCTCGCTTCCGCTTCGGCGGCATGGGCGTGATTT
+TGCCGCTCGCCTCGCGGGTGCAGGCCGAGGCCGCCGTGCTGGGGATGGTCCTCGCCCGCG
+AAGCTGGCATCGCGCTGGCCGACGCCGCCGTGCGGATGAGCGCGGTGGAAGTGCCCGGCG
+GGCGCTACCGACTGCATCCGGGCCGGTTTACCGTCATTGACGACGCCTACAACGCGTCCC
+CGGTGGCGGTGCGCGCCGCGCTCGACGCCCTGCACGCGCTGAAGCCGGAGGGCGAGGTAG
+GCCGCCGCATCAGCGTGCTGGGCCGGATGCTGGAACTCGGCCCCACTGAGCGTGAGCTGC
+ACGCCGAAGTCGGCAGCTATGCCCGCGAGCAGGCCGACCTGACCTACGGGGTGGGCGAGT
+TCGCGCAGGAGCTGGGCGAGCGCGCCTTCGCCACCGTGCCCGAGCTGCTCGCCGACCTGC
+TGAATGAAGTCCGTGACGGCGACATCGTGCTCGTCAAGGCGAGCCGGGGCATTTCCCTGA
+CCCCGGAGCAGCGCGCGGTGACGGGCGTGGGGCTGGACGTGGTGGTGGAGGCCCTGCTCG
+ACCAGCGCGACCGCTGACCTGCCGCTCACCCGGACCCGGCACAATCGGACCATGCCCCTC
+CCGCCCCGCTGGACCACACCGCGCCGCTTGCTTCGCCTTCCCGTGCTGGCCCTGCTGGGG
+GCCTCGCTGCTCGCCTGTGCCCCCGCGCCGTCTGCCGGGCGGGGAAGTGAGGCGGGAAGC
+ACTGCCTCCGCCACTGGCGGGGTCCGCGCGGCCTTCAGCGACGATGGGGTGGCGTGGGTC
+AGTGGGGGCCGGGCGTGCGTGGCCCGCGTGCCGAGCTTTCAGCCGAGTTGCCCGCGCCTC
+GCCCCCGCCTCCGATGTGGGCTGGCAGCAGAGCGGTGGGCAGGGAGCCGACGCCTGGGCC
+GCGCTGCCGGGGCCGGGGCTGGTGGTCACGCTCGACCGGGCGCCGCGCAGCCTGAATGTG
+GGCGCGGTGGTCCTGCTGAGTAGCACCCGCATCTACCGCGAGGACGGCAGCGCCCTGACC
+TACAGCGGCGAAGCGGGTCGTGGCGTGGCCGGAGCGCCGCTGGCCGCCGTGACCGGGGGC
+GACGGGCGCGATTACGTGGTCCTGGGCCGCGAACTGCGCCGGGTGGACGACGGGGCAGTG
+CTTGACCGGGCGGCGCAGCCTTTCCTGTATGCCACCCCCAGCGGGGCCGCCAGTGCCGCC
+CTGCCCACCGCCAGTGACGGCCTGAGCCTTTACCGGCTGACCGGCAGCACCCTGGAACGC
+TTCAGTGCCGGGCAGGTGGTCGCTCGCGTGTCGCATGGCCCAGGGCAGGTGGGGCTGGTG
+CGCGGCGAGGTGGTTACGGTGGACGCGGCGGGCCGGGTGCGGCGATTCACTCTGCAACTC
+GAGCCGCTGAACTGAGCCTGGGACGCCGGGTTTCGGTGCCCTGTCCGTAGCTTGCGAGGG
+GCCAACGAGCGGCTCACCGACGCGCTCCGGCAGGGCCTGGGGGTGTCAGAGTTCCGTAAG
+CGGGGGGATGGTTCCATGGGCAGCGGTATGTCCGCCCTTGCCCTCACTCGCCGGCTTATT
+CCCGCAGCAGCTTCTGCCCGTTTCCGGAGCGTGGCCCAGGCCCCCGCATCGTTGCCGGGG
+GGGCCGGCCCGGGTAGATGAGTGAATGCTAAAATTCGCCGGACTCTGGAGGGAGCATGAC
+GAGCCTCATTAACCGTTTTCGCAGTCGTTCCGCCGCCATCGGCGTGGAGATCGGCACCAG
+CACCATCAAGGTGGTGGCCCTTAAGGCAGGGGCCCCGCCTTCCCTGCAACACGCGGTGAT
+GGTCCCCACCCCCATCGGCAGCATGCGTGACGGTCTGGTCGTCGAACCCCAGGCAGTGGC
+GAGCGAACTCAAAAGCCTGCTGGCCGAGCACCGCATCACCACCCGCCACGCCGTCACCGC
+CGTGCCCAATCAGGTGGCCGTGACCCGCAACATCATGGTGCCGCGCATGGACCGCAAGGA
+CCTGCAAAGCGCCATTCGCTGGGAAGCCGAGCGCTACATCCCTTACCCCATCGACGAGGT
+CACGCTCGACTTCGACCTGCTCGACGACCCCGCCAACGTGCCCGAGGACGGGCAGATGGA
+AGTGGTCATCGCGGCGGCGCCCACCGAGGCCGTGCACCGTCAGATCGAGGTGCTGCGCCT
+CGCGGGCCTCGAACCCACCGTGGTGGACCTCAAGAGCTTCGCGGCGCTGCGGGCGCTACG
+CGGCAACCTGCTCGGCGAGCACCTCACCAAGAGCACCCTAACCGGCACCAACTACACCGA
+GGCCGGCGAGGTGGCGCTGGTGATGGAAATCGGCGCGAGCAGCAGCGTCATCAATCTGGT
+GCGCGGCGACCGCATCCTGATGACCCGCAACATCAACGTGTCCGCCGACGATTTCACCAC
+TGCGCTGCAAAAGGCCTTCGACCTCGACTTTGCCGCCGCCGAGGATGTCAAGCTCGGTTA
+CGCCACCGCCACCACCCCCACCGAGGACGAGGAAGACCTGCTCAACTTCGACCTCAGCCG
+CGAGCAGTACAGCCCGGCGCGCGTGTTCGAAGTGGTGCGCCCGGTGCTCGGCGACCTGAT
+CACCGAAATCCGCCGCTCGCTGGAGTTCTACCGCGTGCAGAGCGGCGACGTGGTCATCGA
+CCGGACCTTCCTCGCCGGGGGCGGCGCCAAGCTGCGCGGCCTGGCGGCGGCCATCGGGGA
+CGCGCTGGGCTTCGGGGTCGAAGTCGCGTCGCCCTGGCTGACGGTGCAGACCGACCAGGC
+GGGCGTGGACACCGGCTACCTCCAGACCAACGCCCCCGAATTCACCGTGCCGCTGGGACT
+GGCGCTGCGGGGGGTGATGGGCCGTGGTTGAAATCAACCTCTTGCCCAAGGAGTATCGCC
+GGCAATCGCAGCCCAGCGTGTGGAAATACGCGTCCTGGGCGGCGGCTGGCCTCACGGCGG
+CGGTGCTCGGCGGCTGGTTCCTCTCGGTGTCGGGCGACACCAATCAGTTGCGCGAACGCT
+CGGCGGCGCTGCAACAGCAGATCGACGCGGTGGCCCCCCAGAAGTCCCGGTTCAACGACC
+TCACCGCCCAGCAGGGCGAACTCGAGCGCGTCACCCAGGTGGCGACGCAACTGCGCGACC
+AGAAGACCTACTGGTCCAACGACCTCGCGTCCTTCGTCGAGCGCGTGCCGGGCAACGTGG
+TGTTCAGCAACGTCAACATGTCCACCGTCGCGCCCGGTGCGGAGCCCAGTCTCGCCTACG
+CAGGCAAGCCCGTAACCCGGCAGCTTGACCTCACCGGCAGCGCCCGCAGTCAGGAAGCGA
+TTGTCGGCTTCCTCAACGCCTTTGAGACCGACAGCAATTTCGGCGTCGATTTCAAGGGGA
+TGCAGCATGACGCTACCAACGGCATCTACACCTTTACCGCCAGCATCGGGGTTGTGGGCG
+ATCAGCCGAGCGCCGCGCCGGGGGCTGACCCGACAGCGCAGGGCGCGCCTGCCACTGGAA
+CGGCACCGGCTGCCCCAGCGGCTCCTGCGCCGACGGCCACCACCCCCGCTGCCGCGCCGG
+CCCAGGGAGGTGCCCAGTGAAAGCCATCAAGCTCGCCCCCCACTACATCTTCGCGCTGGT
+TCTGACCCTGTGCTTGGTGCTGGGCTACCTCTTTTACACCATGGCGATTCAGCCCCGGCA
+ACTCGAAATCACTTCCCTCAACGACGAGATCACCAACAAGGAAACCACGCTCGCCGCCGA
+TCAGGCCAAAGCGGCGCGGGTGCCGACCTTGACGGCTGAAGTGGCCCGCCTCGAAGTCGA
+GCGCGAGAAGTTCCTGCGGGCGCTGCCGCCCACCGCCAACTTCGGTCAGGTGGTCGCCAA
+CCTGCGCCAGACCGTGAGCGCCGCCGGGGGAGACCTCAAAACCCTCAATTTCGCTGGGAG
+CGGCGCGGCGGGGGCCAACCTGCCGGCGGGCGTGCGCCCCATCGGCATGACCATGTCGGT
+CAATGGCCGCTTTCCGCAACTGTTCCAGATTCTGCGCAGCCTGGAACTGCAAAACCGCTT
+TACCACCGTGGACAACGTGAGCCTGCAAACCCAGGGCGACGCCGGCACGGGCGGGGGCGG
+GACGCTGGGCAGCACCCTCGGCCTGACGGTCTATACCTTCGATGCGTCGGGCGCGACGAG
+CACCCCTGACGCGGCGGCTCCGGCAGCGGGCACGCCGGCCCCCGCTGCACCGGCCGCTGG
+AGGCACGCAACCATGAGCCGTTTTCCCACTGAAGACCAAACCCAGACCCAGACCATGACC
+GAGGTCACCAACGTCTCGCAGGAGAAATCACCGCTCAACCTCAACTTCTCGCGCGAAGTC
+AAGCTGGTGCTGGTGGTGCTCGGCATGGTCGCCCTGATCGGCGGCTGGTTCGTCCTGACC
+GGCCAGCCCGACGACCAGACCGTCACCGCGCCGGTCCCCGTGACTACCCCAGCCCCGGAG
+ACGGCCACCACACCTGAAACCGCGCCGGCAGGAAATGCGGCCCCGGACGGTCAGACGGCG
+GGCACGGCCACAGAGACGACGACCACCCCAGGCACTACAGATGAGTCGTCCGGCAAGAAG
+GCGACAGGAACAGCCGCCAAGTCGCAGAAAGGCACGCAGTCTGGCGACGGCTCCGACGAA
+AGCCTGGTGGCGACGGTGCCGCCGTTGGAGGGTGAAGGCACGGCGACCCCACCGGTGCCC
+GTGCCCGGCGGCATCAACCCGGACCGCCCGCTCAAGACCCTCAGCGGCGCGGACCCCTTC
+GGCTCTCTGACGCCCAGTCCGGGAACCGGCACGGCTGGCGGGACGGCTCCAGCCACCCCG
+GTCGAAGCCCAAACTCCGGAAACTCAAAGCCCGGAGACGGCGCCCGAAACGCAGGCACCC
+ACCGCGCAGAGCACTACCAATAGCCCAGCCCCGGTGGTCCTCAGCAGCCCGGCAGGCAGC
+AGTGTCAGCGGGCAGGGCGGCGTGCTCGATTACTCCTCGCGCCTCGATCAAGGGGCCCTG
+CCGACCCCTGTGATCCCAGTATCTCCGACGGAAGTCCGCAGCCCGGTGACCAGCGCTCCG
+GTCAGTGGCAGCTCAGTCAACGGCGACAGTGTCGGCAGCGGCATGGCGACAGCGCCCACG
+GTTGTGGTGAGCACTCCGGCTCAGCCCACCACCACTCCCTCGGCTTCAAGCCCAGTGGCT
+CGGAATACAGCGGGCCAGAGCGGAGCAGGACAGAACACGGGCGCCTCCCGCCCGGCCAGT
+GGCACCCCGTCGCGGGCCAGTGCTCCCAACGTGGTCGTCGTGCGTCCTCCGGCTCGCGTG
+TCCGGTACTTCGGCGGCGGGCGCGACGGGCAGCTCACGCACCGGCGCGGCGGGCACGCCC
+GCAGCAACGCCGACGCGCAACCAGTCTGCGTCCGGCACCCGCCCCGCGTCCGGGCAGACG
+CCGCCCCGAGTCATTGCGGTGGCCCCGGCGGGGGGCGCCCGAACTCCGGCAGCCCCCGGG
+AACAGACCGGCGACCGCCGCACCGACCCGGCCCAGCCCTTCCAGCACCGCTCCCAGCAAG
+ACCGTCGTGGTGCGGCCCCCGGTCCCGGTCAGCGGGCAGCAACCGCCCCGCGTCGTGACC
+AGCCCCGCTGCGGGCGTCCCGGCGGGCAACGCAGCCCCAGCGCCGACCCCGCCTCCAGTC
+GTGGCGGCGCGGGTACCCCAGGCGAACACCGTGCCTGAGCTGGTGGCCCAGGCGGGCACG
+TCGGCGGCCCCGGCCACTTCCGGTGCGTCCGCCGGAACGGGCACGGCTGGTCAAGCGGGC
+AATGACGCCGCTGGCACGGCGGCCCTACCTCCCCTCATCACGGCGGTGGGCAGCGAGGCG
+GCTCCGGCCAGCACCGCTACGGCGGACGCAGGAAGCAGCACCCCGGCGGCGCCGGCAGCG
+ACTGCCCTCGACCGCCTGCTCGCGCCGGGTCAGGTGGCCCTCAGCTCGGTGGTGCTCGGC
+CCGACCAACACGGCGGTGTTCCGCACGCCGCAGGGGTTCGTTGTGGTGGAGCAGGGGCAG
+ACCGTCCCCGGCCTCACCGGCGAAGACGGCACCCCGGTCGTCTTGCAGAAAGTAGAAACC
+GGCGCCGTCACTGTGGCGCTTGGCACCAAGGTCAAATCTCTGGAACTGGAACAAAGGTGA
+GCCATGAATAAACGACACGCCCTCCTCTTGACTGCCGTGCTGGGCATGGCCACCGCTTAT
+GCTCAAACTGCACCGACCACCACGACCGTCAATACGTTGCAGACGGTTTACCGTGACCCT
+AGTCTGACCTCTGCTCCAATTACAGCAAATGTAGGTAAATACGTCGGCCCCCTGTCTACT
+TTCTTGGCAAGCATCGCCAAATCGGCGGGCTACGAAGTGGTTTTCAATTTCAATATTGAT
+GCGCTGGCCCTCATCAACGGTGAAATTGTTTTTGGAAATAGTACCGCTTCAGTGACGACT
+TCCTATGCAACTCCTTTAGGTAGGCCCCAGGAATTACCAGCCAAACCTGTAGTCCACAAT
+TTCTCGAACGCTCCTTTCAACGAAGCTTGGCCTTTGCTTATGGATGTTTATGAGTTGGAT
+TATCAACTAGTTAAAGTTGGTAGTGCAAATGTCATACGAATTGGTCAAAGGCCTAAGCAG
+TTGGCTCTGCCCCTAAAATTTATTTCGGCAGAGAGTGCCTTAACTGCCATTGAGAAATTT
+TTTGGTGAAGAAAAGTTTGAGACCGTGATAAGTTTGGATAGCAATAATAAACCTTTTCAA
+ACTACTCGGCCAACAGGTAAATTTGGATTGCCTAATAGCATAAAAGTAATCCCCGATTCC
+AGCAATAAGCGTTTGATTATTGGTTCCAATAGTGAGGATGGAATAAGAATACGTAGTTTC
+GTAGAAACAATAGATGTACAATCCTCTGGTAAAGTAATATCTACTGATTCCATAAGCGAA
+ATATATATTGTAAGAGGCCAGAAAGAAAGCGTATTACAGTTTTTGAGAGATAGTTTTCCG
+GAATTAATAGTTACCGATTATGCATCTGGAGGCCTTGCTATTGAAGGCCCACGAACAAGT
+GTTAACAGGGCTATAATCTTGCTTGGACAAGTAGACCGTGCACCTGAAATTCCTATTGTG
+CAGCGCATCTACACCGTGCGCGGCCAGGCCGCCGACATCACGGCGCTGCTCGCTGCCCAG
+TACCCTACCCTGCGCGTGACCCCGGTGGGGCAGACCGGCCAACTGGTGCTCAACGGCGCT
+CAGGCCCAGCTCGACACGGCGCTCGCCCTGCTCGAACAGGTGGACCGCCCCGCCCCGGTG
+GCCGAGTCCCGTACCGTTCAGCGCGTCTTCCAGCTCGTCAACGCCAGCGCTGAGGAAGTC
+AAGGCGACCCTGGAAGGCACCCTGGCGCGTGACCTGACCGCCGACAGCAATAACGACGTG
+CTGCCCAACGTGCCCGTCACCGCCACCGACGCCAACGGCAACACGACCGTGGTGAGCGTG
+CCCAACGCGCTCGGCAAGACGGCGAACCAGGGCACGGCGAATGCTCAGGCTCAGACTGCC
+CAGACTCCGGCCAACACCCAGCAGGCGACCCTGATCGCCGACAAGCGCACCAACAGCCTG
+ATCGTGCGCGGCACGCCCGAACAGGTGGCGCAGGTGGCCGAGCTGGTGCCGCAGCTCGAT
+CAGGTGGTGCCGCAGATCAACGTGCAGGTGCGGATTCAGGAGGTCAACGAGCGAGCGCTG
+CAATCGCTGGGCCTCAACTGGCGGGCGACCTTCGGTGGCTTCAACGTGGCGGTCTCGGGC
+GGCACCGGGCTGGCGGCCACCTTCAACCCCACCCAGAGCTTCCTCGGTTTCAACATTTTC
+CCGACCCTCACGGCGCTCGAAACCCAGGGCCTGACCCGGCGCGTGTACGACGGCAACGTG
+ACCATGCAAAGCGGCCAGCGCTCGCTGAGTGCCACGGGCGGCGCCCAGAACGCTTCGAGC
+GGCGCGGCGGCCAGCGTCAAGAGTGGGGGCCGACTGGAAATCAACATCCCCTCGGCGGCG
+GGCAACATCGTGCGGCAGATCGATTACGGTCTCAACCTCGATTTCTTCAGCCCGCAGGTG
+GCGCCCGACGGCACCATCACCCTGCGTATTCGCGGTCAGGTCAACCAGCCGGCAACGGCG
+ATCACCGCCGACAGCCTGCCCAACCTCATCGACTTCACCAACAGCGAAGCGCAAAGCACC
+ATCACCTTCAAGAACGGCCAGACCATCCTGATGAGCGGCCTGCTCGGCAGCACCGAGACC
+ACCAACCGCAGCGGCGTGCCCTTCCTGAGCAGCCTGCCCGGTGTGGGCGCGGCCTTCGGG
+GAAAAACGCACCGAGAAGACCCAGTCGCAACTGCTCGTCATCATCACCGGCACCGTCGTC
+AAATAACGCCTAGAGCAGTTCTCCGAATTACGCGTGCGTCGGAACAGCACCGCCACCCGC
+TCCATTCTCTGCTTCGCAGCTTTGCAAGTCCGTTCTGCTCCGTGTTTGTACTCGCTCTGC
+TCGCCAAAAAGCTGTGCCATCTTTTTGTCAAATGCTCTACGTCATACCGGCGCCTTTCTG
+CGAAGGGGCGCCGCTTTTTTGACTCTCGCGGCGGAGCCTGTTTGCTCAAGCCGCCGCGCC
+GGGGCCGCCAATCCCGCTACAGTCGCCCTATGAGGTACCTGACCGCCGGAGAATCGCACG
+GGCCACAGCTCACGGCCATTATCGAGGGGCTGCCCGCGCAGTTGCCGCTGGGCAAGGCCG
+ACATCGACCCCTGGCTGAGAAAACGGCAGGGCGGCTACGGACGCGGGCGACGCATGGTCA
+TCGAAACCGACGAGGCCGAGCTTCTGAGCGGCGTCCGTGCGGGCCGCACCACCGGCGCCC
+CCGTCACCCTCGCCATTCAGAACAAGGACCACCGCAACTGGACTGAAATCATGTCGCCTG
+AGCCGGGAGGCGAGCCGCGCAAGAAGGCGCTGACCGACGCCCGCCCCGGCCACGCCGACC
+TGACCGGCGGCATCAAGTACCGTCACAAGGACCTGCGCGACGTGCTCGAACGCGCCTCGG
+CGCGCGAAACGGCGGCGCGGGTGGCGGTAGGCAGCATTGCCCTCAAGCTGCTTTCTGAAC
+TCGGCATCGAGGGGGCCAACTATGTCTTCAACCTTGCTGGCATTGAAACGCGGCAGGCCT
+TCTCCTGGGACGCACTCGACGCCATCGAGGACTCCGACCTGCGCACCCCCGATGCCGACG
+CCGCCGCGCAGATGCGCGAGCGCATCGACCAGGCCAAGAAGGACGGCGACACCCTGGGCG
+GCATCCTCGAAGTGCGCTTCCGGGGCCTACCGGTC
+>NODE_9_length_39996_cov_63.0617_ID_17
+GCGGGATGCGCCTGGGCGTGCCGTTGCGCGAGCAGGAGTTGCGCGGGGCGCTGTGGCGCT
+TGCTCGAGGACCCGGCCATGGCGGCGGCCTGTCGGCGTTTCATGGAATTGTCACAACCGC
+ACAGTATCGCTTGCGGTAAAGCGGCCCAGGTGGTCGAACGTTGTCATAGGGAGGGGGATG
+CGCGATGGCTGAAGGCTGCGTCCTGAACGGTGCTGGCATAACAGATAGGGTTGCCATGAT
+TTTGCCGTATCGGCAAGGCTGCGCGCTTGACAGCGTCATACCCCGGGCCAATTCTGCTGT
+GATGCATTTTATCGATCAGGGCTTACTGCAATGAGGAATGACGGAGGCTTTTTGCTGTGG
+TGGGACGGTTTGCGTAGCGAGATGCAGCCGATCCACGACAGCCAGGGCGTGTTCGCCGTC
+CTGGAAAAGGAAGTGCGGCGCCTGGGCTTCGATTACTACGCCTATGGCGTGCGCCATACG
+ATTCCCTTCACCCGGCCGAAGACCGAGGTCCATGGCACCTATCCCAAGGCCTGGCTGGAG
+CGATACCAGATGCAGAACTACGGGGCCGTGGATCCGGCGATCCTCAACGGCCTGCGCTCC
+TCGGAAATGGTGGTCTGGAGCGACAGCCTGTTCGACCAGAGCCGGATGCTCTGGAACGAG
+GCTCGCGATTGGGGCCTCTGTGTCGGCGCGACCCTGCCGATCCGCGCGCCGAACAATTTG
+CTCAGCGTGCTTTCCGTGGCGCGCGACCAGCAGAACATCTCCAGCTTCGAGCGCGAGGAA
+ATACGCCTGCGGCTGCGTTGCATGATCGAGTTGCTGACCCAGAAGCTGACCGACCTGGAG
+CATCCGATGCTGATGTCCAACCCGGTCTGCCTGAGCCATCGCGAACGCGAGATCCTGCAA
+TGGACCGCCGACGGCAAGAGCTCCGGGGAAATCGCCATCATCCTGAGCATTTCCGAGAGC
+ACGGTGAACTTCCACCACAAGAACATCCAGAAGAAGTTCGACGCGCCGAACAAGACGCTG
+GCTGCCGCCTACGCCGCGGCGCTGGGCCTCATCTGATGCTTAGGGCGCGCCGGCTGGCGC
+GCCCTACCAGATCTGGCAGGTTGCCTGCCGTTCATCCTCCTTTAGTCTTCCCCCTCATGT
+GTGTGCTGGTATGTCCTCCGACTGAGAGGGCCCAGGAGTATCAGGGTAGGGATGCCGCCT
+TTTTTTCTCGGCCGGCACGACACGGGGACTTGGTCATGATCGAATTGCTCTCTGAATCGC
+TGGAAGGGCTTTCCGCCGCCATGATCGCCGAGCTGGGACGCTACCGGCATCAGGTCTTCA
+TCGAGAAGCTGGGCTGGGACGTGGTCTCCACCTCCAGGGTCCGCGACCAGGAGTTCGACC
+AGTTCGACCATCCGCAAACCCGCTACATCGTCGCCATGGGCCGCCAGGGTATCTGCGGTT
+GTGCCCGCCTGTTGCCGACGACCGACGCCTACCTGCTCAAGGAAGTCTTCGCCTACCTGT
+GCAGCGAAACCCCGCCCAGCGATCCGTCGGTATGGGAGCTTTCGCGCTACGCCGCCAGCG
+CGGCGGACGATCCGCAACTGGCGATGAAGATATTCTGGTCCAGCCTGCAATGCGCCTGGT
+ACCTGGGCGCCAGTTCGGTGGTGGCGGTGACCACCACGGCCATGGAGCGCTATTTCGTTC
+GCAACGGCGTGATCCTCCAGCGCCTCGGCCCGCCGCAGAAGGTCAAGGGCGAGACGCTGG
+TCGCGATCAGCTTCCCGGCCTACCAGGAGCGCGGCCTGGAGATGCTGCTGCGCTACCACC
+CGGAATGGCTGCAGGGCGTACCGCTGTCGATGGCGGTGTGAGGTCGTCAGCCATTTCGCG
+CACTTTTTTCCGCTTCTCCTGCCGCATGCTCGGCCCGCGCCCCGGCGTCATCGGGCGTTC
+CCCTGCATTCCGGGATTTGGCCGCGGCTGCCGACTTGCGTAGTCTCTCTGCGGTCCGCCA
+TCCCGAGGAGTCGCCATGCCGAAGTCATTCCGCCATCTCGTCCAGGCCCTGGCCTGCCTT
+GCGCTGCTGGCCAGCGCCAGCCTCCAGGCGCAGGAGAGCCGCCTCGACCGCATCCTCGAA
+AGCGGCGTGCTGCGCGTCGCCACCACTGGCGACTACAAGCCCTTCAGCTACCGCACGGAA
+GAGGGCGGTTACGCCGGTTTCGACGTGGACATGGCGCAGCGCCTGGCCGAGAGCCTGGGG
+GCCAAGCTGGTAGTGGTGCCGACCAGTTGGCCGAACCTGATGCGCGATTTCGCCGACGAC
+CGCTTCGACATCGCCATGAGCGGCATCTCGATCAACCTGGAGCGCCAGCGCCAGGCGTAT
+TTCTCGATTCCCTACCTGCGCGACGGCAAGACGCCGATCACCCTCTGTAGCGAAGAAGCG
+CGTTTCCAGACCCTGGAGCAGATCGACCAGCCGGGCGTGACGGCCATCGTCAACCCCGGC
+GGCACCAACGAGAAGTTCGCCCGGGCGAACCTGAAGAAGGCCCGGATCCTGGTGCATCCG
+GACAACGTGACGATCTTCCAGCAGATCGTCGACGGCAAGGCCGACCTGATGATGACCGAC
+GCCATCGAGGCCCGCCTGCAGTCGCGTCTGCACCCGGAACTCTGCGCCGTGCATCCGCAG
+CAACCCTTCGACTTCGCCGAGAAGGCCTACCTGCTGCCGCGCGACGAGGCCTTCAAGCGC
+TACGTCGACCAGTGGCTGCACATCGCCGAGCAGAGCGGCTTGTTGCGCCAGCGCATGGAG
+CACTGGCTCGAATACCGCTGGCCCACCGCGCACGGCAAGTAATACAGGGCCGGCGAGGGT
+GGCCGCGGGCCCGCGCGGCCTTCCTTGGCGGCGGCAAAAACGTTATGGTCGGCGCCCCAT
+CCTGGTGCCTGGTCCATGCGTTATCTACTGTTCGTCACCGTCCTCTGGGCGTTCTCCTTC
+AACCTGATCGGCGAGTACCTCGCCGGCCAGGTCGACAGCTACTTCGCCGTGCTTACCCGG
+GTCCTTCTCGCTGGCCTGGTGTTTCTCCCGCTGACCCGCTGGCGCGGCGTCGAACCGCGT
+TTCGTCGGCGGGGTGATGCTGGTCGGCGCGCTGCAGTTCGGCATCACCTACGTCTGCCTG
+TACCTGAGCTTCAACGTGCTGACGGTGCCCGAGGTGCTGCTGTTCACCGTGCTGACGCCG
+GTCCACGTGGCCCTGTTCGACGACCTGCTCAACCGCCGCTTCAACTTCTGGGCCCTGGCC
+GCCGCGCTGGTGGCGGTGCTGGGCGCGGCGATCATCCGCTACGACGGGATCACCGGCGAG
+TTCCTCCAGGGCTTCCTGCTGCTGCAACTGGCCAACGCCACCTTCGCCGCCGGCCAGGTG
+CTGTACAAGCGCCTGGTGCGCAAGTACCCGTCCGAGCTGCCGCAGCGCCAGCGCTTCGGT
+TATTTCTTCGTTGGCGCGCTGCTGGTGGCGTTGCCTGCCTGGCTGCTGTTCGGCGATCCG
+CAGCGCCTGCCGGCCGGCGAGCTGCAATGGGGCGTACTGGTATGGATGGGGCTGCTGGCC
+ACCGCCCTCGGCCAGTTCTGGTGGAACAAGGGCGCCACCGAGGTGGACGCCGGTACCCTG
+GCGGTGATGAACAACCTGCACGTGCCGGTCGGGTTGCTGCTCAACCTGCTGATCTGGAAC
+CAGCACGCCGACCTGCCGCGCCTGGCCCTGGGCGGCGCGGTGATCGTCGCTTCGCTGTGG
+GTCAACCGGCTCGGCCGGCGCGAGGTGCGTGCATGAGGATTTCCGGACAGGGCGTGCTGC
+TGTCGCTGGCCGCCTCGGTGCTGTTCGTTACCCTGCCGGGCTACGTCCACCTGCTGGAGC
+CGCTGGACAGCCTGCAGGTGGTGGCGCATCGGGTGGTCTGGTCGATCCCGATGGTATTCC
+TGCTGGTCGTCGCCACCCGCCAGTGGCCGACCCTGCGCGCTGCCTGGCGCCGGCTGTTCG
+CCGAGCCCTGGCTGCTGGCCTGCTTCCCGCTGACCGCGGCGATGATGCTGCTGCAATGGG
+GCATCTTCATCTGGGCGCCGTTGGCCGGGAAAACCCTTGAACTGTCGCTGGGCTACTTCC
+TCCTGCCGCTGGCGATGGTGCTGGTGGGGCGGGTGTTCTACGGCGAGCGCCTGACGCCGC
+TGCAGGCTATCGCCGTGGCCTGCGCGCTGGCCGGGGTGCTCCACGAGTTCTGGCTGACCC
+GCGCGTTCTCCTGGGTCTCCCTGGTCACCGCGCTGGGCTATCCCCCGTACTTCATGCTGC
+GGCGCAGGATGGGCGTGGACGCGCTGTCCGGGTTCGTCTTCGAGATGCTCTTCCTGCTGC
+CGCTGGCGTTGGCCGCGCTGTACTGGCTGGGCGACGAGAGCCAGGCCTTCCGCGAGGCGC
+CGCGCCTGTGGCTGCTGCTGCCGATGCTGGGGCTGATCAGCGCGCTGGCCTTCGGCGCGA
+TGATGGCTTCCAGCCGGCTGCTGCCGATGGGGCTGTTCGGGATTCTCAGCTACGTCGAAC
+CGGTGCTGCTGTTCCTGGTGGCGGTACTGTTCCTCGGCGAGGCGTTCCGTCCCGAGCAGC
+TATGGACCTACGCGCCGATCTGGCTGGCGGTGCTGTTGACCGGCTGGGACAGCGCGCGCC
+TGCTGAGGAAACAGGCGCGGCGGGGCATCTGAGCGAGCCGCAGGCGCCGGAATCAGCGCT
+TGCGGGTGCTTTCGACCTGGGCGAGGGTGGTCGGCAGGATGCGCTTGCCGGCCAGGTAGT
+GGCGTTTCCAGTAGCTGCTGTTGAGGTCGGAGACGCGGACCTTCTTGCCGCGCCGCGGCG
+CGTGCACGAAGCGGTCGTTGCCGACGTAGATGCCGACGTGGTCGACGCTGCGGCTGCGGA
+TCCGGAAGAACACCAGGTCGCCCGGTTGCAGCTTGCCGCGGGAGACCTTGTTGTTGTCCA
+TGTTGTAGATGGCGCGGGCGGTCCGCGGCAGGTCGACGTCATCGACGTCCTGGAACACAT
+AGTTGACCAGGCCGCTGCAATCGAAGCCTTTCTTCGGCGTGGTGCCGCCCCAGCGGTAGG
+GGGTGCCGATCATGCTGAAGGCGCGGTCGGTGACTTCGGAAGCGGCGGCCGCGACCACCG
+AGCGGTTGGCGGACTGGCGGGTGCTGACGACCCGGCTGGGCGACAGGGTGGAATTCTTCG
+ACGGCTTGAAGGTGTGGGTGACCTGGTTGGAAGCCAGGCTGGGCGTCGAGAGGGCGGCCA
+GAAGGGCCGCGAAGCCTACAGACAGGCATGTCAAAAAGGGTGAACGCATTTCGGCATGTC
+TTCGCGTGCGTGAATAACGGTCCAGGCTTCCGCTGGTTCGTGGTTACTCTCTGTTCATCG
+GAGTGTCTTCTGGGTGACCGGAACGAGCCCTCCTGACTCTTCCGACCAGGCCGTCAAACG
+AAACGGCCAACTGCTTCCGGGCCTGGATGCATTCAGGTTGTCCCGGCGATAACGGGCTTC
+ACGAAGGAAAATCGGGGACTCATCGGCGTTCCCAGCGTATTCCCCTACGAAAGCGGCGGC
+TATTGTGACCTATTTTGACGCCGGCCTTCTGACCATTCGTCGAATGATCGGTTCCGGATG
+TGACGCGCCGGTTTCGCCGTGCAAGTGGCGATACTTGCGGGTCCGGCAATGACCTGTTGT
+TCGCCGTGGCCTTGGAAAGCCTCTGCGCCGGGGGTATGTTCGTGTTCCCCGTACCCGAGT
+GAAGCCCGTAGAAGCGAGTCCAGATATGACCGAAACAGCCAAGCGTCCCTTGTACGTTCC
+CCATGCCGGCCCATCGCTGCTGGAGATGCCGCTGCTGAACAAAGGCAGCGCGTTCAGTAC
+CCAGGAACGCATCGATTTCAACCTGCAGGGCCTGCTGCCGCACAACATCGAGACCATCGA
+GGAGCAGACCGAGCGCGCCTACAGCCAGTACAACCTGTGCAACACCGATCTGGACCGCCA
+CATCTTCCTGCGCTCGATCCAGGACAACAACGAGACCCTGTTCTTCCGCCTGCTCGAGGA
+GCACCTGGAAGAAATGATGCCGATCATCTACACCCCCACGGTCGGCCAGGCCTGCCAGGA
+GTTCTCGAAGATCTACCGGACCCACCGCGGCCTGTTCATCTCCTACCCGGACCGCGAGCG
+GATCGACGACATCCTGCGCAGCGCCACCAAGAACAACGTGAAGATCGTGGTGGTCACCGA
+CAGCGAGCGGATCCTCGGCCTGGGCGACCAGGGCATCGGCGGGATGGGCATCCCGATCGG
+CAAGCTGTCCCTGTACACCGCCTGCGGCGGTATCAGCCCGGCCTACACCCTGCCGGTGGT
+GCTGGACGTAGGCACCAACAACCCGGACCTGCTCAACGACCCGATGTACATGGGCTGGCG
+CCACGAGCGGGTGAGCGGGGCGCAGTACGAGGAGTTCGTCGACCTGTTCATCCAGGCGAT
+CAAGCGCCGCTGGCCCAACGTCCTGCTGCAATTCGAGGACTTCGCCCAGACCAATGCCAT
+GCCGTTGCTGGAGCGCTACAAGGACGAGCTGTGCTGCTTCAACGACGACATCCAGGGCAC
+CGCCGCGGTGGCCGTGGGCACCCTGCTGGCGGCTTGCAAGGCCAAGGGCGAGAAGCTCAG
+CGAGCAGACCGTGACCTTCGTCGGCGCCGGCTCCGCCGGTTGCGGCATCGCCGAACAGAT
+CATCGCCGCCATGCAACTGGAGGGCCTGGACGAGGCCCAGGCGCGTCGGCGCATCTTCAT
+GGTCGACCGCTGGGGCCTGCTCACCGACGACATGAGCAACCTGCTCGACTTCCAGCACCG
+CCTGGCGCAGAAACGCGCCGATCTCGGTGCCTGGGGCGGCCAGCAGGGCGACGACCTGGC
+GTTGCTGGAAGTGATCCGCAATGCCCGGCCGACGGTGCTGATCGGCGTCTCCGGGCAGCG
+CGGGCTGTTTTCCGAAGAGGTCATCCGTGAGCTGCACAGCCATTGCAAGCAGCCGCTGGT
+GATGCCGCTGTCCAACCCGACCTCGCGGGTCGAGGCGACTCCGCAGGAAATCCTCAACTG
+GACCGACGGCCAGGCGCTGGTCGCCACCGGTAGCCCGTTCCAACCGGTGCAGGTGGGCGA
+CAAGCGGATTCCCATCGCCCAGTGCAACAACGCCTATATCTTCCCCGGCATCGGCCTGGG
+GGTGATCGCCGCGCGGGCCAACCGGGTCACCGAAGGCATGCTGATGGCCGCGGCCAACGC
+CCTGGCCAACTGCTCGCCGATCGTTACCCAGGGCGAGGGCGCCGTGTTGCCGGCGCTGGG
+CGACATCCGCGAGGTCAGCAAGCGCATCGCCGTCGCCGTGGCCAAGCAGGCCCAGGCCGA
+GGGCAAGGCCCTGCATACCAGCGACGAGGTACTGAACGACGCCATCGAGGCGAACTTCTG
+GTTCCCGCGCTACCGTGCCTACCGCCGGACTTCGTTCTGAGGCTCAGCCGCAGGCTGCGC
+ACGGGGGAGAGGCGTTAACCGCCGATATTCCGCGCGATCGGTGCGAGAACGCGAAAAGGC
+CACGAGGTGGCCTTTTTCGTTGACGGTAGCGCTAGCGCTAGCGCACATGATCGGGGCGCG
+TCCGGTGTTCGGCCTGGGTTTCCGGGTTTTCCGCCGCGCGCCGCGCCAGGGCCGGCAGGA
+CATGATCGCGCAGCAGCGGCGCGAGATTGTCCGGCTGCGCTTGGCCGGGGACCAGCCAGG
+CCAGTTCCTCCAGCTCCGCCTGCGCACAGACGGCGTGGGGCAAGCGGGCGACGTAGATAT
+CGGCATCGACGCGGGTGTTCGCCTCGTTGGCCGCCGGGGCCTGGAAGCTGCCGAGGTGCT
+CGAAGGTCGAGGCGCCCATCGGCAGGCGCAGTTCCTCCAGCAGTTCGCGCTGTAGCGCGG
+CGAGGGGCGTTTCGCCCGGCTCGCGCTTGCCGCCCGGGAGCATGAAGGCCTGGGTGCCGC
+GCTTGCGCACCAGCAACAGGTTGCCCTGGTCGTCGAACAGGCAGGCGGCGGAAATGCTCA
+GCAGGTTGTCGGTCATTGCGGGTCGTCCTCGGCGATCACCTGGTAGCGCATCTGTACGAT
+GCCGCTGTTGTAGCCATGTTGTTCCAGCAGTTGCAGGCGCCGCTCGCGGCCGCCGGCGAA
+CAGCGGGATGCCGGCGCCGAGCAGCTGCGGAATGACGCTGACGATCACCTCGTCGAGCAG
+CCCGGCCGCCAGGCAACTACCGGCGAGGCTGCCGCCGCCGGCCAGCCAGACCCGCCGGCA
+GCCCTGTTCGCCGAGGCGTGCGAGGCCTTCCTGGGGCGTGCCATGGCGCAACTCGACGCC
+TTCCACCGCGCTCTCCCGGGGATTGCGGGTGAGCACCTGGCAGGGCTTGCCCGGATACGG
+CCAGTCGCCGAAGCCGCGCACGATATCGTAGGTGCCGCGGCCCATCAGCAGCCCGTCGAT
+GCCCTGGTAGAAGCCGTTGTAGCCATGGTCGTTGCCGCCCTCGGCGAAACGGTCGAGCCA
+GTCGACGCTACCGTCGGGACGGGCGATGAAGCCGTCCAGGCTGGTGGCGACGTAGTAGAT
+CAGGTGCGGTTTCATGGACGGCGCTCCCCTCGCTTCAGACAGTGGCTTCGTCGCTGCGGC
+TCGGTGCGGCCAACGCCTCGAACGAACGGGCCTCGGCGTCACGCCCTTCGAGCATGCCCT
+GCAGTCCCTGGCGCAGGTCCTGGCCGCTGGGTTGCTGGTAGGCGCCGAGGCCGAACTCCG
+GCATCACCGCCAGCAGGTAGTCGAACACGTCGCCCTGGATGCGCTCGTAGTCGACCCAGG
+CGGTGGTGCGGGTGAAGCAGTATATCTCCAGCGGGATGCCCTGGGCGGTCGGCTGCAACT
+GGCGGACCATGCAGGTCATGTGCGGATGGATGTCCGGATGGTTCTGCAGGTAGGCGAGGG
+CGTAGGCGCGGAACGTACCGATGTTGGTCAGCCGGCGGCGGTTGGCGGCCAGCGGGGCGA
+CCCCGCCGTTGGCGGCATTCCACTCCTGCAACTCGGTCTGCTTGCGGGCCATGTATTCGG
+TGAGCAGGCGCACCTGGCTCAGGCGCCGCTCTTCCTTCTCGTCGAGGAAACGCACCTGGC
+TGGAGTCGACGTAGATCGCCCGCTTGATCCGCCGTCCGCCGGACTGCTGCATGCCGCGCC
+AGTTCTTGAACGACTCCGACATCAGGCGCCAGGTCGGCACCGAGACGATGGTCTTGTCGA
+AGTTCTGCACCTTCACGGTGTACAGGGTGATGTCCACCACGTCGCCGTCGGCGCCGACCT
+GCGGCATCTCGATCCAGTCGCCGACTCGCAGCATGTCGTTGCTGGTGAGCTGCACGCTGG
+CGACGAAGGACATCAGGGTGTCCTTGTAGACCAGCAGGAGGACCGCCGACATCGCGCCGA
+GGCCGGACAGCAGCAGGAGCGGCGAGCGGTCGATGATGATCGAGACGATGATGATCGCGC
+CGAACACGAACACGGCGATCTTCGCCAGTTGCACGTAGCCCTTGATCGAGCGGGTGCGGG
+CGTGCTCGGTACGCGCGTAGATGTCCAGCAGGGCATTCAGCAGCGCGGTGAGGGCGAGGA
+TCAGGAACAGCACGGTGAAGGCCAGTGCCAGGTTGCCGAGGAAGTGCGCGGCCTTGTCCG
+GCATCTCCGGGATCCATGGCAGGCCGAATTGCACCAGCAGCGAGGGCGTGGTCTGCGCCA
+GGCGCTGGAACACCTTGTTGCGGATCAGGTCGCCGAGCCAGTGCAGCGCGGGCTGGCGGG
+CGAGCAGGTTGGCGGCGTAGAGGACGATGTAGCGGGCCACCCGGCCGAGGATCAGGGCGC
+CCACCAGCAGCAGGCCGAAGGCCAGGCCGGCGTGCAGGATAGGGTGTTGGTCGAGCGCCG
+ACCAGTACCCGGAGAGCTGGTCGAGAAGGGATGTGGAGTCCATGGACAGGCGACTTCCTT
+TGTTGCGGGCGGGGGGGACGGGCCGGCCCCGCGGTTGAACGGACATCCCGACGCGGGGGC
+CGGGAACGCACAAAGGAACCAAGAGTGCCCCATCGGGCGCCGGATCGCATCCCCGACGTG
+TCTACAAAGGTTTTCCGCCGACGCGCGGGCTCAGCCGGCAAGCTCCTCCAGGGTGCGCCC
+GCGGGTCTCGATGCCGAAGGCCCAGACCACCAGGGCGGCGACGCCGAAACAGAGGGCGCC
+GAGGGTGAACACCCCGCCCTGGCCGGTGAGCGGCAGGACCAGCCCGGTGACCAGCGGGCC
+GAGCAGCGAGCCGATCCGCCCGACCGCCGAGGCGAAGCCCGAGCCGGTGGCGCGCGCGGA
+GGTCGGATAGAGTTCCGGGGTATAGGTGTAGAGCACCGCCCACATGCCGAACAGGAAGAA
+CTGCATGGCCAGGCCGAAGCCGATCAGCAGTGCCAGGCTGCCGCCGAACACCGCGGTCTG
+GCCGTAGGCGTAGGCCATCGCGCCGCCGCCGAGGAGCATCAGCACGCAGCTCGGCTTGCG
+GCCCCAGCTTTCCACCAGCCAGGCCGCGCAGAGGAAGCCGGGTATCCCGGCCAGCGAAAT
+CAGCACCGTGTAGTACACCGACTGGGTGACGGCGAAGCCGGATTGCTGGAGCAGCGTGCT
+GAGCCAGGAGGTCAGGCCGTAGAAACCGAGCAGGGCGAAGAACCACAGGCCCCAGACGGT
+CAGGGTGCGGCGCCGGTAGGCTGGCGACCAGAGTTCGGCGAAGGCGCTGAAGAAGCCCGG
+ACGGCTGCGTTCCCGCTGCGGCTGGCGCAGCGGCGGCGGCAGTTCGGACAGGCCCAGCGA
+ACGCATCACCCGTGTTTCTATGTCGCGCAATACCCGGTCCGCCTGTTCGCGCCGGCCGGC
+CTGCTCCAGCCAGCGCGGCGACTCGGGAATCAGGAAGCGGATGGCGAGGACGAACACCGC
+CGGCAGCGCCAGCACCAGGAAAATGCTGCGCCAGCCGGTCAGCGGCAGCAGGAAGTAGGA
+CAGGCAGCCGGCAGCGACGAAGCCCAGCGGCCAGAAGCCGTCCATCAGCGCAATGTACTT
+GCCGCGGCGGCTGGCCGGGATCATCTCCGACAGCAGCGACTGGGCGATGGGAAACTCCAT
+CCCCATGCCGATCCCCAGCAATACCCGGTAGAAGGTCAGGCTGTCGAGGTCGCCGGCGGT
+GGAGCACAGGTAGCTGGCCAGGCCCCAGAGCACGATGCTGGCCTGGAATACCGGCTTGCG
+CCCGAAGCGGTCGGCGAGCATGCCCGACAGGGCCGCGCCGATCACCATGCCGAAGAAGCT
+CGAGCTGGCCAGCAGCCCGGCCTGCGCCGAGTCGAGCCCGAACTCGGCTTTGATCGAGCC
+GAGCAGGAAGGTCATCATCGCCAGGTCCATCGAGTCGAAGAAGAACGCCAGCGCGATGAT
+CACGAAGACCAGTCGGTGATACGGACTCAGCGGCAGCCGTTCGAGGCGTTCGGCGGCGGA
+TGCGGGCGCGTCGGGCATGACCTGGTTCCTCTGGGCGGCGGGCGTCGAACGAGTCTGCGA
+TCGCCGCCCGCGCCGTGCTTGCCTGGCGGCGACCCGGCGTCGAGCCGATTGCGACGCCGG
+CGCTGGCCGTCGCGCCGCGCGAATAAAGCCTGCGCGCCGGCGCGGCAACCGTTAGGCTAT
+GCACCTGTCCATTTTCACGTGCAATGCCGAGGTTTCCCTTGTTCAGCCAATTTCCCCTCC
+ACGAACGCCTGCTGAAGGCACTGGAAAGCCTGTCCTTCAGCGAGCCGACGCCGGTCCAGG
+CCGCGGCCATTCCCAAGGCGCTGGAGGGGCACGACCTGCGGGTCACGGCGCAGACCGGCA
+GCGGCAAGACCGCGGCCTTCCTGCTGCCGCTGCTGCACCGCCTGCTGGCCGAGGACAAGC
+CGCGCTCCCTGGCGCGCGCGCTGATCCTCCTGCCGACCCGCGAGCTGGCCCAGCAGACCC
+TCAAGGAAGTCGAGCGCTTCGCCCAGTTCACCTTCATCAAGGCCTGCCTGATCACTGGCG
+GCGAGGACTTCAAGGTGCAGGGCGCGCGCCTGCGCAAGAACCCGGAGATCATCATCGGCA
+CCCCCGGCCGCCTGCTCGAGCAGCGCAACGCCGGCAACCTGCCGTTGCAGGACATCGAGG
+TGCTGGTGCTGGACGAGGCCGACCGCATGCTCGACATGGGCTTCGCCGACGACGTGCTGG
+CCCTGGCCAATGCCTGCCCGGCCGAGCGCCAGACCCTGCTGTTCTCCGCCACCCACAGCG
+GCGCCGGGTTGAACAAGGTGATCGCCGAGGTGCTGCGCGAGCCGCAAGTGCTGCGCCTGA
+ACCAGGTCGGCGAGCTGAACGAGAATGTCCGCCAGCAGGTCATCACCGCCGACGACGTGG
+CGCACAAGGAACAGTTGCTGCAATGGCTGCTGAGCAACGAGACCTACACCAAGGCCATCG
+TCTTCACCAATACCCGGGTCTCCGCCGATCGCCTGACCGGGCGGCTGATCGCCAACCAGC
+ACAAGGTCTTCGTCCTGCATGGCGAGAAGGACCAGAAGGACCGCAAGCTGGCCATCGAGC
+GCCTGAAGCAGGGCGCGGTGAAGATCCTCGTCGCCACCGACGTCGCCGCACGCGGCCTGG
+ACGTCGAAGGCCTGGACCTGGTGATCAACTTCGACATGCCGCGCAGCGGCGACGAGTACG
+TGCACCGCATCGGCCGGACCGGTCGCGCCGGCGCCGAGGGCCTGGCGATCTCGCTGATCT
+GCCATGGCGACTGGAACCTGATGTCGAGCGTCGAACGCTACCTCAAGCAGAACTTCGAAC
+GACGCAACATCAAGGAACTGAAGGCCGCCTACCAGGGGCCGAAGAAACTCAAGGCGTCGG
+GCAAGGCCGCCGGCAGCAAGAAGAAAAAGCAGGACAGGAAGGGCGCCGCCGCCAAGCCCG
+CGGCCAAGCGCAAGCCCGCCGCGCGGCCGAAGGCCGGGCCGTCGGCGGTGGTCAGCGCCG
+ACGGCATGGCGCCGCTCAAGCGCAAGAAGCCGACGGCGGAGTGATCGCGCGCCGCCGACC
+GCTTCGGAGGGCGGATAACCGTTTGCGGTTATCCGCCGCGCCGGCGTTGGATGGCGGATA
+ACGCCGCTGGCGCTGTCCGCCCCGGGGGACTGCCTGGCCCCGTTCTCAGCTCCCCGCCGT
+CGCGCCCGCCTCGTCGTTGGCCGGCGGCGTGGCACTCTTCACCAGCGGCGTATCGTAGCT
+GCTCGCCTCGTAGCTCACGCAATGGCGGATCTGCGGCGGACCGTCGCCGGCATGCAGGGC
+GGTGACGTTGTCGATGACGATCTTGTCGGCCAGGGTCATGCGGTCGAGCATGCGCAGGTG
+CTGGATCCAGTTGTCCACCAGGAACAGTTCCTGCCAGACCTCCGGGTTGCTCACGTCGCG
+GAACAGCGACCAGCGCTCCGCGCCGTTGCGCAGGCGCAGGCGGCGCAGCGGCTGGGCGGC
+GCGAACGAAGTCGCGGGTGCGCTCGGCGGGAATCCGGTATTCGATGGAGACCAGCACCAT
+GCCCCGCCGCGTGTTGAAGACGAAGCTCGGCTGCCCGGGCATGCTCGCCGGCGCGCGGGA
+AATACTGGCGGCGTCCATTTCCGGCAGGCGCGAGTTGTACAGGAGGATCACCGAGGCCAG
+CAGCAGGCAGCCGGCGGCCAGCAGCGCGCCGTGCACGGTCATGGTCTCGGCGAGATGGCC
+CCAGAGGAACGAACCCAGCGCCAGGCCACCGTACAGCGCGGTCTGGTACAGCGCCAGGGC
+GCGCGCCTTGATCCAGTCGGGGACGAGGATCTGCACCGCCGAGTTGTAGGTGGCGAGGGC
+GCCGATCCAGCAGCCGCCACCGAGGATCAGCACCGGGAACAGGACCCAGAGGTTGTCCAC
+CAGGCCGAGGGTCAGCAGGATCAGCGCCAGGGTGAAGCCGGCCAGGCTGATCAGCCGGCT
+GCTGCCGATCCGCTGGCGCAGACGCGAGACCTGGGTGCTGCCGAGGATCGCGCCGAGGCC
+GAGGGCGCCGAGCATGTAGCCGTAGATCGCCGCGTCGCCGTCCGGGTTGCGGTGCGCCAG
+CAGCGGCAGCAGGGCCCAGACCGCGCTGGCGGAGAGGCCGAAGGCGAAGGAGCGCATCAT
+CACCAGGCGGGTGACGGTTGAGTACTGGGTGAAGCGCAGCGCCGCGGTGACGCCTTCGAG
+GATGCCTTCCGGCGGCAGGCTGCGCTTGGGCACGTCGCGCCGCCACTGCCAGATCGCCCA
+GATCAGGGCCATGTAGCAGAAGCTGTTGAACAGGAACACCCAGGCCGGTCCCACCGCGCT
+CAGCAGCAGGCCGCCGAGGGCCGGGCCGGCGGCGCGGGCGACGTTGTAGTTGACGCTGTT
+GAGCAGCACCGCGTCGCTGACCATGCGCGCCGGCACCTGCTCGTTGACCGCCGCCTGCCA
+GGCCGGGATGGTCACCGAGCCGCCGAGGGAGATCCAGAGGATGGAGATGATCAGCAGCAC
+CGGGTCGAGGTAGCCGAGGAAGGCCAGCAGGGTGGCGAACATCGCTCCGGTCATCTCGAA
+GCTGAGCCCCCAGAGCATGATCTTGCGCCGGTCGTGGTTGTCGGCGATGACCCCGGAGAG
+GATCGACAGCAGCACCAGCGGCAGTGCCGCGGCGACCTGGATCATCGCCACCATCAGCGG
+GCTGGCGTGGGCGTCGGTGACCACCCAGGCGGCGGCCACCGACTGGGCCCAGGTGCCGAG
+GTTGGCGAACAGGTTGCAGATCCAGATGATGCGGAAGGCCTGGATCGAGAACGGCGCCCA
+GGTGCCGGTGCGTTCTGGCTTGGCCGCTTGGCCTTCGGGTTTGAGGGGCAGGTCGTGCTT
+GGGCGAAACGGACTGGAGCATCAGATGGGTGCCTTGTATCAGCGTGCCTGATGTCGGGAA
+AGTCTAGCCGCCTGGCGCCTGGGCGCCATTGATGGCGGTCATGGGGCCGGCCCGGCGTGG
+ATAGACATTGGTCCGATGGCGCTATCGGAGAGTTCCGATGTCCAGGCAGGACAGTGCCCT
+GGGTGTCCCGCATTGGTAGGCTTGCCGGCACCGAGTCGAGACAAGAGCGAAAAGCCGATG
+AAGTTGCTGTTGCGTTGCCTGCTGCTGGGGGCGTGGGTCGTCTCGCCGAGCCTGTGGGCC
+TGGTCCAACCATACGGTGGGCAGCTACCTGGCATTGCGCGAGCTGGCGGCCATCCGCGAG
+GCGCCGGAAGTCGAGGTGGAGCCGCTGGAGGCGTTCCTCGCCGCCGAGCGCGGCGGACTG
+GCCGCCCTGCTGGACGAGCAGGAAGCCTACGCCCGAGCGCATATCGGCAACTACCCGGCG
+CGTCCGGACGCCCTGCGCTTCGCTGCCGAGGGCGAGGCCGGCGACTTGCGTCAGGCGTTC
+CTCGCGGCGCTGCGGGTCAACCCGGAGATCCGCCTGGCGCTGGCGCTCCAGCCGCTTCCC
+GGGCAGGACCAGCCGCAGCGCCCGCACCTCAAGCCACAGGAGGTGCTGGTGTTCCAGAAC
+CTCTCGCCGTGGACCGCCTGGCGTTTCATCCGCCTGGAGCCCGGCGAGCGAGTCGCGCCC
+CTGGCAGTGCTGGCCACCGCCGCCGACGAACCGGACTACGGCCACGACATCAACCTGTTC
+AGCGACAACCCCGGCGAAGCCGGCCAGCGCTACGGCTTCGGCACCCAGCCATTCGGCGAC
+CCGCGCTTCGAGTTCAGCTCCCAGGCGCCGTTCCACATGGGCTTCTATCACGAGGCGGCG
+GTGATCTACAGCGGCGCGCCGTTCCTCGCCCGGGCCTGGCCGGAATGGCGTGCCTACCAG
+TACTTCGGCCTGTCCCGCTTCGCCTTCGCCAACGGTCATCCCTACTGGGGCTACCGGTTC
+CTTGGCTGGGGCATGCACTACATCCAGGACATCACCCAGCCCTACCACTCCACGCCGCTG
+CCCGGTGCCAGCCTGGCGGCGATGCTACAGATGGAGGGCAAGGCATTGCTCGGCTACCCG
+GAGGAAAAGCAGGCGGCCATCGAGCGTGTCGCGAACCGCCATACCGCGGTGGAGAAATAC
+CAGTTCGACTGGCTGCGCCAACTGCTCCGCGACGGCCGCCCGCAGCCGATGCTCGACGCC
+TACGCCGACACCCGCCGCGACGGTGCCTATCCGGCCTATTCGCCGACCTACTTGCGCGAG
+GTGGTGGCCGCCGAGTCGAACGCCCACGCCGCGGCCTTCGACGCCGCCATCGGCGAATGG
+CTGGCCGCCCGCCCGGCCTCCGCCGCGCAGGACTTCAGCGAGAGCAACCAGCCACGCCCC
+GAGGCCCACGACAATGCGGGGCTGAACGCGCAACTGATCGAGCTGATCGGGCATTTCGGC
+GCGCATAGCCGGAACATCGTCAGGGCGGCGTTGGAGACGGAGGAGGGTGGGGCGAAGGAG
+TGAGGGGGCGGCGGATAAGCGGCGGATAACCGCGAGCGGTTATTCGCCCTACGGAGCGGG
+GGCACTGTCCGGCGTTTCCGGGGCGTGTAGGGCGAATAACGCCATGGGCGTTATCCGCCG
+ATGTCGCGGATAAGCGGCGGATAACCGCGAGCGGTTATTCGCCCTACGGAGCGGGGACGC
+TGTCCGGCGTTTCCGGGGTGTGCAGGGCGAATAACGCCATGGGCGATATCCGCCGATGTC
+GCGGATGAGCGGCGGATGACCGCGAGCGGTTATTCGCCCTACGGAGCTGGGGCGCAGTCC
+GGCTTTTTCGGGGTGTGTAGGGCGAATAACGCCATGGGCGTTATCCGCCGATGTCGCGGA
+TGAGCGGCGGATGACCGCGAGCGGCTATTCGCCCTGCGGAGCAGGGGCGCTGTCCGGCGT
+TTCCGGGGTGTGCAGGGCGGCGAACCCGCCCCGCCAGGCGGGTCGATGCCGCGACTCAGT
+CGCGCAACAGCTCCGCAGGCACCTCGCTGCGCAACATCAACTGGCACTGCTGGCTCTCCG
+GGTCGAACAGGATCACCGCCTCGCCCCGCCGCAAGGCATGCCGGGCGCGTTCTACACGCA
+CGTCCAGCGGGGTCTCGTCGCCATTGTCGGTGCCTTCGCGGGTGACGAAGTCTTCCAGCA
+GGTTGTTCAGGGTGTCGGCTTCGAGCAGGTCGTGGGGGATCAGCATTGGCGGTACTCCGG
+GATGGCGGCGAATGCTAGCGCGACGCATCGCGCACTGTCATGCCTGTCGCGAAGGCTGGC
+CGAGCAGGCGTTCGAGGGTGGCATAGAGTTCCGCCCGGTCCACCGGCTTGCCGAGGTAGG
+CGTCCATGCCAGCCTCGATTCCGGCCCGGCGGTGTTCGTCGAGGATGTGCGCGGTCAGGG
+CGACGATCGGTACGCGTGGCCAGCCCTGGGCACGCTCCTCCCGGCGGATCAGGCGGGTCG
+CCTCGAAGCCGTCCATTTCCGGCATCTCGCCATCCATCAGGATCAACTGGATGCCGTTCG
+GATCGCGCAGGTACTCGTCCAGCGCGAGCCGTCCGTTGCCGGCCAGGCGCACCGCGTAGC
+CGCGCTTGGCGAGGAAGCCGCGCACCACCAGCTGGTTCACCGGGTTGTCCTCGGCGACCA
+GGATGCATGGGGCGTCCAGGCGTTCGTCCGGGGCCGCCTCGCTGCTCCGCCCTGGCTGTC
+GGCGCCGCTCCCGGTACAGTTCCAGCAGGGCTTCGCGCAGGGCCTTCACCGCCACCGGCT
+GGGCCAGGGCCAGCAGGCGCAGGCCTTCGTGCGGCGGCAGGTCCTGGCAGTGCTGCGGCG
+GGCATAGCAGGAGGATGCGCTGGCCTTGCTCCAGTTGCGCATAGAGGGTGTCCAGCCAGA
+TCGACGGCGGCCCCGGCCAGGGCGCCGCCAGGACCAGCAGGGGCGGTGCGCTGAAGTCCT
+CCAGGTAGGCGTTCAGCCGTCTCGGCTGCAGGCAGCGTTCGACCCGCAGCCCCCAACGCT
+CCAGCAATGCCTGCAGGCAGTCCAGGGTCAGGTTGTCCTCGCTGGCCAGCAGGGCCGGGC
+GGTGTTGCAGCAGTTGCGCCAGTTCATCCGCTTCGCCGGCGTCGAGGGCGGGGCTGAGCG
+GCAGGTCGACGCTGAACCGGGTGCCCTTGCCCGGCTCGCTGCTCACCTCGATGCGCCCGC
+CCATCATCTGCACCAGCTCCCGGCTGATCGCCAGGCCCAGGCCGCTGCCGCCGTAGCGGC
+GGGTGGTGCTGGAGTCGGCCTGGGAGAAGGATTCGAACAGGGTCTTCTGCGCCTGGGCGG
+ATATCCCGATGCCGCTGTCGCTGACGCTGTACAGCAGGCGCTCGTGTCCGCCCTCGTCGA
+AGCGCCGCTGCACGCGCACGGCGACATGGCCTTCGGCGGTGAACTTGAGGGCATTGCTGA
+GCAGGTTCATCAGTACCTGGCGCAACCGCGTCGGGTCGCCGTTGAGGCGGCGCGGCACGC
+CCCTGTCCAGGCCGAGATGCAGGCGCAGGCGTTTTTCCACGGCCTGGGCGCTGAACAGCG
+CCAGGGTGTCGGAGAGCAGTTCCTCCAGGTCGAAGTCGATGCGCTCCAGGTGCAGCTTGC
+CGGACTCGATGCGAGCGTAGTCGAGGATATCGTTGATCACCGACATCAGCGCGCTGCCGG
+AGCTGGCGATGGTCTCCACGTAGGCCGCCTGGCCGCGGTCCAGCGGGGTGTCGCGGAGCA
+GTTGCAGCATGCCCAGCACGCCGTTCAGCGGGGTGCGAATCTCATGGCTCATCTTCGCCA
+GGAAGCGGCTCTTCGCCTCGTTCTCCACCCGCGCCTGCTCGGCCGCCTGGCGCGAGCGGA
+AGCCTTCCTCCTTGAGCGCATTGATGCGGTCGGCGAGGCCGATGGACAGGGTCACCAGTT
+CCACGGTCATGCCGATCTTGACCACGCTGCTGCCGAACAGGCCGAACAGTTCGAAGCCCA
+GCGAGGCGGCGGTGGTGACCAGGAACGACAGCAGCAGCGCGCCCCAGGCCAGGATGTAGT
+AGAGGCCGTAGCGCAGGCCCTGGCGCCAGACGTGGACGCCGGCCAGCAGCAGGCTGAGGG
+AGACCAGCATCACCGTCAGGCTGGCGAGGACGTTCCAGGCGCGCAGCCCCACCAGCGGCT
+CGCTGGCCAACAGGACCACGCAGGCCAGCAGCAGGCCGCGGAGGAAGCGGTCGAGGCGCG
+GGAAGTCGCGGCGGGTGTAGAGGTAGCCGCGGCTGAACTGGATCGACACCAGGCAGCTCA
+GGTACATCAGCAGGTAGATGCCGGCCGACTCCAGCGCCACGTGTCCGGGCAGCAGCTTGA
+ACAGCAGGCCGTCGAAGCTGGCGGAAAACAGGCCGAGGCTGAGGTTGTACAGCAGGTACC
+AGGCATAGGTGGCCTCGCGTAGCGAGACGAAGAGGAACAGGTTGTAGCAGAACAACCCGA
+ACAGCACCCCGTAGAAGGCCCCGTTGAAGCCCATCAGGGTTTCCTGGCTGGCCGCGCTGG
+CCGCGTAGGTGCTGAAGTACAGCGGCACGTAGACGGTGCTGGTGCTCTGCACGCGCAGCA
+GCAGGGTGCTCTCGCCGGGCGGCAGTCGCAGCGGGAACCAGAAGTTGCGCACTTGCACCG
+GGCGCTGGGAGAAGGCGAACAGGTCGCCGCTCTCCTGCTGTTCGATGCGCCCATCGGCGG
+TCAGCAGGTAGACCTTGAGGTCGTCCAGCAGCGGGTAGTTGATCTCCAGGAAACCGGCCA
+GGTCGGTGCCGTTGCGGTTGTCCAGGCGCACCCTGAACCACCAGGCTGCGGCGTTCTTGC
+CGAAGTTCGCGTGGTCGCCGCGCAGGGCGGCGAAGGCCTGCGCCGGCAAGGCGAGGATGT
+CGCCCAGACGCGCCTTGCCGCCGGCGTCGCGGTAGTACTCGGCGTACTCGCCCAGGGACA
+GGCGCAGGTCCTCTCCGTCCAGCGGCGCGGGCGGCTGCGCCCGGGCCGGCAGCGCGCAGC
+AGAGCAACAGCAGGACCAGGCAGAGTCGAGACATGCAACTACTCCATGGACACGAGTCGG
+CACGCATGATGCTACGGAGGAAACGAGACAGGCGAGGGAACCTGCCATCAGCCTAGCAGT
+TGGCTGGAGAGGAGGGCGGCCTCCCCGGAGGCGGGGAGGCCGGCGCGGGCTCAGCCCTTG
+TCGCTGTTGTTGCTGCTGTCGAGCACTTCGTCCACCGGCGGGACGTGGGTGCAGCTTTCC
+ATGTGCACCGGATGCTCGAGCTGCTTGTTGAAGCGTTCCAGCGAGGTTTCCCGGGGCTTG
+GCGTCGCTGGCGAAGACCGGCGGGCTGAGGATGTAGGCGGTGAGCAGCCGGCTCAGCGCG
+GCGAGACTGTCGATGTGCGTGCGCTCGTAGCCGTGGGTGGCGTCGCAGCCGAACGCCAGC
+AGCGCGGCGCGGGTGTCGTGGCCGGCGGCGATCGCCGACTGCGCGTCGCTGTGGTAGTAG
+CGGAACAGGTCGCGGCGCAGGGCGATGTCGTGGCGCTCGCCGAGCCGCAGCAGGTGCCGC
+GACAGATGGAAGTCGTAGGGCCCGCCGGAGTCCTGCATGGCCACGCTGACGCTGTGCTCG
+TTGGAATTCTGGCCTTCGGCCACCGGGGCGATGTCGATGCCGACGAACTCGCTGACGTCC
+CAGGGCAGGGCGCCGGCGGCGCCGGAGCCGACTTCCTCGGTGATGGTGAACAGCGGGTGG
+CAGTCGATCGGCGGCTCCTGGCCGCTTTCCTTGACCGCCTTCAGCGCCGCCAGCAGCGCC
+GCGACCCCGGCCTTGTCGTCCAGGTGGCGGGCGCTGATATGGCCGCTCTCGGTGAACTCC
+GGCAGCGGATCGAAGGCCACGTAGTCACCCACCGAGATGCCCAGGCTCTCGCTGTCGGCG
+CGACTGGCGGTATAGGCGTCGAGACGCAGCTCGATGTTGTCCCAACTGATCTTCAGGTTG
+TCCACCTCGGTATTGAAGGCGTGGCCCGAAGCCAGCAGCGGCAGCACGCTGCCACGGAAC
+ACGCCCTGTTCGGTGAACACCGTGACCCGGCTACCCTCGGCGAAGCGGCTCGACCAGCAG
+CCTACCGGGGCCAGGCCGAGGCGGCCGTTGGGCTTGATCTCGCGGACCAGCGCGCCGATC
+GTGTCGAGGTGCGCGGAAACCGCCCGGTCGGGGGTATTCAGGCGGCCCTGGAGGGTCGCC
+CGGATGGTTCCCCGGCGAGTCATCTCGAAGGGCACGCCAAGTTCGTCGAGCTGCTCGGCG
+ACATAGCGCACGATGGTATCGGTGAAGCCGGTGGGGCTGGGGATGGCGAGCATCTCCAGC
+AGCACCCGTTGCAGGTAGTTGAGGTCCGGTTGTGGCAGAGGGGTCATGAAGGCACCTCGC
+GGCTGAGGGGGAAGAGAAGATCGACGAAGCGTTCGGCGGTCGGCTGCGGCTCGTGGTTGG
+CCAGGCCGGCGCGCTCGTTGGCTTCGATGATCACGTAGTCGGGCTGGTCGGCGGCCTCGA
+CCAGGAAGTCCAGGCCCACCACCGGTATTTCCAGGGCCCGCGCGGCCTGGATTGCGGCCT
+CGCGGAGGGCCGGATGGAGGGCGTCGGTGACGTCCTCGAGGATGCCGCCGGTGTGCAGGT
+TGGCGGTGCGCCGCACGGCCAGGTGTTCGCCGCTGGGCAACACGTCGTCGTAGCCATAGC
+CGGCGGCCCGCAGGGTGCGCTCGGTCTCGTGGTCGAGCGGGATGCGGCTTTCCCCGCCGG
+TGGCGGCCTGGCGCCGGCGGCTCTGCGCCTCGATCAGCTCGCGGATGCTGTGCCGGCCGT
+CGCCGATCACCGCGGCGGGACGACGGATGGCGGCGGCCACCACCTCGTAGCCAATCACCA
+GCACGCGCAGGTCGTGGCCGGCGTGGTAGCTCTCCAGCAGCACGCGCGAATCGAAATGGC
+GGGCGGCCTCGATGGCCTCCTCGACCTCTTCCGCGGTGCGCAGGTCCACCGCCACGCCCT
+GGCCCTGCTCGCCGTCCACCGGCTTGACCACCAGCGAACCGTGCTCGGCGAGGAACGCGG
+CGTTTTCCTCCGCGCTGCCGGCCAGGCGCTGCTGTGGCTGGCGCAGGCCGGCGTGCTGCA
+GGGCGCGGTGGGTGAGGACCTTGTCCTGGCAGAGGGTCATGCTTACCGCCGTGGTCAGGT
+CGGAGAGCGATTCACGGCAGCGGATCTGCCGGCCGCCCTGGGTCAGGGTGAACAGGCCGC
+CCTCGGCGTCGTCGACGCGCACCTCGATGCCGCGCCGGTGGGCTTCGTCGACGATGATCC
+GGGCGTAGGGGTTGAGGTCTTCCTCCGGGCCGGGGCCGAGGAACAGCGACTGGTTGATGC
+CGTTCTTGCGCTTGATGGTGAAGGTCGCCAGTTCGCGGAAGCCGAGCTTGCGGTAGAGCG
+CCTTGGCCTGCTGGTTGTTGTGCAGCACCGAGAGGTCGAGGTAAGCCAGTTCGCGGCTCA
+TGAAGTGCTCGACCAGGTGCCGTACCAGCGCCTCGCCGACGCCCGGCCGGCTGCATTGCG
+GGTCCACCGCCAGGCACCAGAGGCTGGAGCCGCCCTCCGGATCCTGGAACGCCTTGGCGT
+GGTTGAGGCCCATCACCGTGCCTACCGCGACGCCAGTGTCGGCGTCCTCGGCCAGCCAGT
+AGATCGGCCCGCCCTGGTGGCGCGGGCTGAGGCGCTCGGTCTGCACCGGAAGCATGCCGC
+GCGCCAGGTACAGGCGGTTGATCGCCGCCCAGTCCTCCTCGGTATGCACCCGGCGGATGC
+GGAAACCGCGTGGCGGACGGCGCGCCGGGCGGTAGTCGGTGAACCACAGGCGCAGGGTAT
+CCGAGGGATCGAGGAAGAGCTGCTGCGGGGCGTGGGCCAGGACCTGCTGCGGCGCCGCCA
+CGTAGAGCGCGATGTCGCGTTCGCCGGGGGCTTCCTGCAACAGGTCGCGGGCCAGTTCCT
+CGGCGTCCGGGTAGGTCTGCCCGATCAGCAGGCGGCCCCAGCCGCAGTGGATGCTCAGCG
+GTTTCTCGGTGGGCTCGCTGTGATCTTCGGCGAGACGCGCCTGGAGGCGTTCGTAGGTGG
+GCGCCTGGATACGTTGCAGGCGCTGGTTGTGCGGGTGAGGCAGATGCAAGTGGCCTTTCA
+TGATCGCTCCTGGTTCGGGCCCCTGCGTTGGGGGCCCATTTTCAAAGTCCCTGTTCGCTG
+AGCCAGAGGTTGAGGGCGGCCAGCTGCCACAGCTTGGAGCCGCGCAGCGGTGTGAGGTCG
+CCGTCCGGATCGCTCAGCAGGCGATCGAATATCGCCGGCTGGAACAGGCCGCGGTCCTGG
+CTCGGGTCGAGCAGCAGTTCGCGTACCCATTCGCGGGTGCGGCCCTGCAAGTGCTTGAGG
+CCGGGCACCGGGAAGTAGCCCTTGGGCCGGTCGATGACTTCGCTGGGAATCACCTTGCGC
+GCGGCACCCTTGAGCACCTGCTTGCCGCCGTCGCCGAGCTTGAAGCGGGCGGGAATGCGC
+GCCGACAGCTCGGCCAGGCGGTAGTCGAGGAACGGCACGCGGGCTTCCAGGCCCCAGGCC
+ATGGTCATGTTGTCGACCCGCTTGACCGGGTCGTCGACCAGCATGATCGTGCTATCCAGG
+CGCAGCGCCTTGTCCACCGCGGCCTCGGCGCCGGGGCTGGCGAAGTGGTCGCGGACGAAG
+CGCCCGGCGACGTCCTCGACGCGGAAGCGCTCGCCGACGGTGGCCAGGTATTCCTCGTGG
+TCGCGGTCGAAGAACGCCGCGCGGTACGCGGCGAAGGCGTCGTCGGCGCCATCCACCTTC
+GGATACCAGTGGTAGCCGGCGAACAGCTCGTCGGCGCCCTGGCCGCTCTGCACCACCTTG
+CAGTGCTTCGAGACTTCCCGCGCGAGCAGGTAGAAGGCGATGCAGTCGTGGCTGACCATC
+GGCTCGCTCATGGCGCGGAAGGCCGCCGGCAACTGCTCGATCACTTCGTGCTCGCCGATG
+CGCAGGCGATGGTGACGGGTGTGATAGCGCTCGGCGATCAGGTCGGAATACTGGAACTCG
+TCGCCGCGCTCGCCGCCGGCATCCTCGAAGCCGATGGAGAAGGTCAGCAGGTTGTCCACC
+CCGGCTTCGTGCAGCAGGCCCACCAGCAGGCTCGAATCGACCCCGCCGGAGAGCAGCACG
+CCGACCTCGCGGGCGGCGCGCTGGCGGATCGCCACCGCTTCGCGGAGGCCGTCGAGGACG
+CGCTCCTGCCAGTCGTCGAGCGTCAGCTCGCGCTCGTCCGGGCGTGGGCCGTAGTCCAGC
+GTCCACCAGGTGCGCTGCTCGCAGCTGCCGTCGAGGTCGACGCTCATCCAGGTCGCCGGC
+GGCAGCTTCTTCACGCCCTCCAGCAAGGTGTGCGGGGCGGGAACCACGGCGTGGAAGTTG
+AGGTAGAAATTCAGCGCCTGCGGATCGAGGTCGCTGGCGATGTCGCCGCCCTTGAGCAGG
+GCCGGCAGGCTCGAGGCGAAGCGTAGGCGCGAGCGGTCGAGGCTGTAGTAGAGCGGCTTG
+ATGCCGAGTCGGTCACGGGCCAGGAACAGCCGCTGGCGATCGCGCTCCCAGACGGCGAAG
+GCGAACATCCCATTGAGCCGGGGCAATAAATCGGCGCCCCAGGCATGGTACCCCTTCAAG
+AGAACTTCGGTGTCGCCGCCGGAGAAGAACCGATAGCCAAGGCTTTCCAGTTCGCCACGC
+AGTTCGGGGTAGTTGTAGATGGCGCCATTGAACACCATGGCCAGGCCGAGATCGGGATCG
+ATCATCGGTTGGCCGGAAGCTTCCGCCAGGTCCATGATCTTCAGCCGTCGATGTCCGAGG
+GCGATCGGACCCTGGGCGTGGAAGCCCCAGGCGTCGGGGCCGCGAGGGGCCAGGTGGTGG
+GTGATGCGTTCGACCGCTGCGAGGTCGGCTGCCTGGTTGTCGAAACGAAACTCTCCTGAT
+ATGCCGCACATATTCCTTACCGGTTCTCCGTTGGGGAAGTGGGTTGCGTACCCCTTCCGG
+GTACATGACTTACCTAACAGAGGACCGTTACAGTTGGAAGGAGTTCTATACGAATTTTCC
+GGGCCTATCAGGACCCTTAACGAAGAATTTATTATGGTTGAAAGTAATAAGACCGCTGCC
+GATACCTATTCGCTCGCTATTTTCCGCGCCATCCGCCGTCTCCAGCAGGCCGCCGAAATC
+CACTCCAAGCGTCTCAGCCGATACGGTGGCCTGACCCCGCTGCAATTGCTGATCCTGCAT
+GTCCTGGCGGTGGAGGGAGAACTGACCGCGACGCAACTGGCCAAGCTGGTCAGCCTGTCC
+CAGGCATCGCTCTCCGGCGTGCTCGACCGCCTCGAAGGACGCGGCCTGCTCTATCGTCGG
+CGCGACGAACAGGACCGGCGCAAGTCCTGGCTGCACCTCGACCCGGCCGGCCACGAAGCC
+CTGGCGGAGGCGCCGCCGCTATTGCCGGAGTACGTGATCGAGCGCTTCGCCGCGTTGCCC
+GAGTGGGAGCGCCACGGCCTGCTGGCCGCGCTGCTGCGCGCGGCCGACCTGTTCGGCTTG
+CCGGAAGAGGACGTCGAAGAAGAGTGAGGGCGCCAGGTTCGCTACGAAAGACAGTCGCGT
+CGGCGGTCTTTACCTGGCGAACCTGCCGATGCCTGGTGGACAAGCGCGTTGTACGCCATG
+GCGTGACCTTCGCGTAGGGCGCATAACGCCGCTTCCCCGGTGCCCCGGCCGCCGAGGAAA
+GCTACCCGCCGTAGAGCTTCTGCGCCGCCAGGGAGAAGCTCACCGCCACCAGCATCAGCG
+CGAACAGGCGTTGCAGGGTCGGGCCGCCGAGGCGCTGCGCCAGCAGGTTGCCGCCGAGCA
+CGCCGACCGCGCCGCCGGCGGCGAGGCCGCCGAGCAGCGGCAGCGGCGGGTGGGCGCCGG
+TCAGGTAGATCAGGAAGCCGCCGCCGGAGACCAGCGCGATCACCGCCATCGAGGTGGCGG
+TGGCGGCCATCATCGACAGCGGGGTGAACCAGAGTAGCCCCGGCACCACCAGGAAGCCGC
+CGCCCACGCCCATCAATCCCGACAGCAAGCCGACCGCCAGGCCGATGCCGAGCAGCGGCA
+GGCTCCGTGCCTGGTCGCTGGCCTCGCGTTTCATCCCGGCGCCGCGCCACATGCGCCAGG
+CCGACCAGAGCACCAGCAGGCAGAAGGCGACGATCAGCACGCCTTCCGGGACGAAGCGGC
+CGAGCCATTGGCCGACGGCGTTGCTCGGCAGGCCGGCCAGCGCCAGGACCAGCACCGGCC
+GCCAGGCCACCTGGCCCTGGCGCGCGCGCGGAATGGCGCCAATCAGCGCCGACAGGGCGA
+CCGCGCCGAGGCTCACGCCGATGGCGTCGCGCAGCGGCAGGTGCAGGCTGAGCAGCAGGG
+GCAGGGCGACCAGCGAGCCGCCGGCGCCAGTGAGGCCGAGCAGCAGGCCGAGAACGGCGC
+CGATGCCCAGGGATTCGAAGAGCAGTACATCCATCGTCGATCAACTGTTTCCGCGGGTGA
+GCCAGCCGGTGGTCCGGTATGGCCTGCGCGTGCGGCAGGCCCGAAGGGTAGCGCAAATCG
+GTGCGCCCTGGGCTTCAGCCGCGCTGCCCGCGCACCAGGTCGCGGAGCAGGAAGCGGTTC
+GGGTGGCAGGCCTCGGCCACCGCGCGCGGCAGCGGCAGCGGCTCGCCGCAGATCCACGCC
+GCCAGCAGTTCGCCGGACAGCGGCGCACTGATCAGCCCGCGCGAGCCGTGGCCGCTGTTC
+AGGTACAGGCCTGGCAGCCAGGGGCAGGCACGCTCCGGCGCCTGGCGGGCGTCGCGGGCG
+AGCACCGCGTAGGCCTCGTCGAAGGCCGCGCGCTCGGCCAGCGGGCCTACCAGGGGCAGG
+TAGTCGGGGCTGGTGCAGCGGAATGCCGCGCGGCCTTCCAGGCGCTCCAGCGGCAGGTCG
+TCGGCGCCCAGGCGCTGCAACAGGTCGGGGGATATTTCCCGCAGCAGTTCGAGGTTGCCC
+TGGTGTTCGGCGAGGGTCGGCGCCAGGTCTTCGCTCTTGAAGTCGAAGCTGGCGCCGAGG
+GTGTGTTCGTCGCCACGCGGCGGTGCGACGTAGCCCTCGGCGCAGACCACGGTGCGCAGC
+GCCCGGCTTTGCGGGGTGGCCGGCAGGCGGGTGACCTGCCCGCGAATGCGCTTCAGCGGC
+AGCTCGGCGGCGGGCGGGAAGTCGCGGATGTCGGCGGCGGTGGCGAGGATCGCGAGTGGC
+GCGCGGGCCAGGCATTCGTCGCCGGCGTAGGCGCACCAGTCGTCGCCCTCGCGGCGCAAG
+CGTACTGCCCGGCCGCTCAGCAGGGTGATCCCGGGGGTGGCGGCCAGGGCCTGGCACAGC
+GCGGGCGGATGGACCCAGCCGGCTTCGGGATAGAACAGGCCGCCGGCGGGCAGGGCGACG
+CCGGCGAGGCGCTCGGCCTGCTCGCGCTCCAGGCCGTGCAGCAGGTCGGCGGGGAAGGCT
+GCGGCCAGTTGCGCCTGGCGTTGCGCTTCCTTGGCGTCGAAGGCCAGTTGCAGTACGCCG
+CAGGCATCCCAGTCGTGGCCGCGCCGCAGGCGTTCGAGCAGCCGGCGGGTATGGCCGAAG
+CCGCTGAGCACCAGGCGCGACAGCGGCGTGCCGTGGGCCGAGAGTTTCAGGTAGAGCACG
+CCTTGGGGGTTGCCCGAGGCTTCCCGGGCGAGGCCGGGATGGCGTTCGATCAGGGTCACC
+TGCCAGCCGCGCGCGGCGAGGCTGGCGGCGCTGGCGCAGCCGGCCAGGCCGCCGCCGACC
+ACCAGTGCCGCGCGGCGCCCGGCGTGGGGCGCGGGGCGTGCGTACCAGGGCTTGCCGGCG
+TTCGCCGGCGGCCCCTGGTAGGTGCCGCTGAGCATCTCGCGCTTCTGTCCGTAGCCCGGT
+ACCCGTTGCATGGCGAAACCGGCCTCGACCAGCCCGCGGCGAACGAAACCGGCGCTGGTG
+AAGGTGCCCAGGGTCGCCTGCGGCGCCGACAGTCGCGCCAGTTCGGCGAACAGTACGGGC
+GACCACATGTCCGGGTTCTTCGCCGGGGCGAAGCCATCGAGGAACCAGGCGTCGACCCGC
+GCGTCGAGCTGCGGCAGGCACTCCAGGGCATCGCCCAGCAGCAGGGTCAGGCCGACCCTT
+CCGCCCGCGAACGCCAGGCGCTGGAAGCCCGGGTGCACGGCAAGGTACTGGCCCAGCAGG
+GCCTCGCTCCAGGGCGCCAGTTCCGGCCATAGCGCCAGGGCGCGGCGCAGGTCGGCGGCG
+GCGAGGGGGAATTTCTCCACGCTGACGAACTCCAGGCGCGCGCCGGCCGGCGCGACCCGC
+TCGAACAGCTGCCAGGCGCAGAGGAAGTTTAGTCCGGTGCCGAAGCCGGTCTCGCCGATA
+CACAGCACCTCGCCGTCGCCCAGCGCGGCGAAGCGCTCGGCCAGGCGGTTGGTGGCGAGG
+AACACATGGCGCGTCTCGTTGAGCCCGGAATGCCGGGAAAAATATACGTCGCCGAAGGCG
+CGGGATAGCGGCTGGCCGTTTTCGTCCCAGTCGAGCTGGGCATGCTGGAAGTCGGACATG
+GCAGAACCTGAAAAAGCGGATGGCGCATTTTACGGGGCTTTGCCGGCCAGCGGCGAGGCG
+CTGCGCGAACATGCCGCGGCGCCGCGCAGACAGCCGCACGCCGATCCGCTACCTTGAAGG
+ACTCAGGTTAAGGGAGACCTCCATGTTCGAATCCGCGGAAGTTGGCCACAGCATCGACAA
+GGACACCTACGAGAAGGCCGTCATCGAGTTGCGCGAAGCGCTGCTCGAGGCGCAGTTCGA
+GCTCAAGCAGCAGGCGCGCTTCCCGGTGATCATCCTGATCAACGGCATCGAGGGCGCCGG
+CAAGGGGGAGACGGTCAAGCTCCTCAACGAGTGGATGGACCCGCGCCTGATCGAAGTGCA
+GAGCTTCCTCCGTCCCTCCGACGAGGAACTGGAGCGGCCGCCGCAGTGGCGCTTCTGGCG
+GCGCCTGCCGCCCAAGGGGCGGACCGGTATCTTCTTCGGCAACTGGTACAGCCAGATGCT
+CTACGCGCGGGTCGAGGGGCATATCAAGGAGGCCAAGCTGGATCAGGCCATCGATGCCGC
+CGAACGCTTCGAGCGCATGCTCTGCGACGAAGGCGCGCTGCTCTTCAAGTTCTGGTTCCA
+CCTCTCCAAGAAACAGCTCAAGGAACGCCTCAAGGCGCTGGAAAAGGACCCGCAGCACAG
+CTGGAAGCTCAGTCCGCTGGACTGGAAGCAGAGCGAGGTCTACGACCGCTTCGTGCATTA
+CGGCGAGCGCGTGCTGCGCCGCACCAGCCGGGACTACGCGCCCTGGTACGTGGTGGAAGG
+CGTGGACGAGCGCTACCGCGCCCTGACCGTCGGTCGCATCCTCCTCGAAGGGTTGCAGGC
+CGCGCTGGCCACCAAGGAGCGCGCCAAGCGCCAGCCGCACGCCGCGCCGCTGGTGTCGAG
+CCTGGACAACCGCGGCCTGCTGGACTCCCTGGACCTGGGCCAGTACCTGGACAAGGACGC
+CTACAAGGAGCAGCTCGCCGCCGAGCAGGCCCGCCTGGCCGGGCTGATCCGCGACAAGCG
+CTTCCGCCAGCATTCGCTGGTCGCGGTGTTCGAGGGCAACGACGCGGCCGGCAAGGGCGG
+CGCCATCCGCCGTGTCACCGACGCGCTGGACCCGCGCCAGTACCATATCGTGCCGATCGC
+CGCGCCGACCGAAGAGGAGCGTGCGCAGCCCTATCTCTGGCGCTTCTGGCGGCACATTCC
+GGCGCGTCGCCAGTTCACCATCTTCGACCGTTCCTGGTACGGCCGCGTGCTGGTGGAGCG
+CATCGAGGGCTTCTGCGCACCGGCCGACTGGCTACGCGCCTATGGCGAGATCAATGACTT
+CGAGGAGCAGCTCAGCGAGTACGGGATCATCGTGGTGAAGTTCTGGCTGGCGATCGACAA
+GCAGACCCAGATGGAGCGCTTCAAGGAACGCGAGAAAACCCCCTACAAGCGCTACAAGAT
+CACCGAGGAAGACTGGCGCAACCGCGACAAGTGGGACCAGTACGTGGACGCGGTGGGCGA
+TATGGTCGACCGTACCAGCACCGAGATCGCGCCCTGGACCCTGGTCGAAGCCAACGACAA
+GCGCTTCGCCCGGGTCAAGGTGCTGCGCACCATCAACGACGCCATCGAGGCGGCGTACAA
+GAAGGACAAGTGAGGCCTGCCGGAATGCGGCGCCGTCCTCTCCAGGGGATGGCGACGCAT
+ACGCCGGATGAATGATCGGTGCCTCGCGCGATTGCCTCGCCTTATCCTCGCTCGATCCGG
+CCGCTGCCCCGGCGGCCGACCGACAATAACAGCGAGGGTACCCCCATGCGTGAAGTGGTG
+ATCGTCGACAGCGTCCGGACCGGCCTGGCCAAGTCCTTCCGCGGCAAGTTCAACCTGACC
+CGGCCGGACGACATGGCCGCCCACTGCGTCGACGCGCTGCTGGCGCGCAACGACCTCGAC
+CCGCTGCTGGTGGATGACTGCATCGTTGGCGCCGGCTCCAACGAAGGCGCCCAGGGCCAC
+AACATCGGGCGCAACGTGGCGGTGCTCTCCGGCCTCGGCATCCAGGTGCCGGGGATGACC
+CTCAACCGCTACTGTTCCTCCGGCCTGCAGGCGATCGCCATCGCCGCCAACCAGATCGCT
+TCCGGTTGCAGCGAGGTGATCGTCGCCGGCGGCGTCGAGTCGATCACCCTGACCCTGAAG
+AGCGTCAACACCGACCACCTGGTGAACCCGCTGCTGCAAAGGGAGGTGCCGGGCATCTAC
+TACCCCATGGGGCAGACCGCCGAGATCGTCGCCCGTCGCTACGGCATCACCCGCGAGGCC
+CAGGACGCCTACGCCCTGCAGAGCCAGCAGCGGATGGCGCGAGCCCAGGCGGACGGGCTG
+TTCGCCGACGAGATCGTGCCGATGACCACCCGCTACGCGGTGGAGGACAAGGCCAGCGGC
+GAGAAGCAGGTGCTCGACGGAGTGGTCGACCGCGACGACTGCAACCGCCCGGACACCACC
+CTCGAAGGCCTGGCCTCGCTGAAGCCGGCGTTCGCCGAGGACGGTTCGGTCACCGCCGGC
+AACGCCTCGCAACTCTCCGACGGCGCCTCGATGACCCTGCTGATGAGCCTGGAGAAAGCG
+CTGGCGCTGGGCCTGGAGCCGAAGGCCTTCTTCCGTGGCTTCACCGTGGCCGGCTGCGAG
+CCGGACGAAATGGGCATCGGTCCGGTGTTCTCGGTGCCGAAGCTGCTCAAGGCGAAGGGG
+CTGAAGATCGCCGACGTCGATCTCTGGGAACTCAACGAAGCCTTCGCCTCGCAGTGCCTG
+TACTGCCGCGACCGGCTGGAGATCGACAACGAGAAGTACAACGTCAATGGCGGCTCCATC
+GCCATCGGCCACCCGTTCGGCATGACCGGCTCGCGCCAGGTCGGTCATCTGGTCCGCGAA
+CTGCACCGGCGCAACCTGCGCTACGGCGTGGTGACCATGTGCGTCGGCGGCGGCATGGGC
+GCCAGCGGGCTGTTCGAAGCCGTACGCTGAGCCCGTGCGCGACGGCGGGCCCCGCAGGTC
+GGGGCTCGCCTCATGGGTTTTATTTACATGACGCTCCGTGCCATCCCCGGCGACTCGCGC
+TAGGCTAGGCGCCTTTTTCCTTGCATAGGGATGTAGCGATGTCCACCGAGCCCAACTCGC
+CGTTCGTCGACGACCCGCTGAGCGCCGTCGATGCACGGGTTCTCGGCAGCCTCGTCGAGA
+AGCAGGCGACCACCCCGGAAACCTATCCGCTGACCCTCAATGCCCTGGTCCTCGCCTGCA
+ACCAGAAGACCAGCCGCGATCCGGTGATGAACCTCACGCCCGGCCAGGTCGGCCAGAGCC
+TGCGCCAGCTCGAGGGGCGCGGCCTGGTCAGGCTGGTGATGGGCAGCCGCGCCGACCGCT
+GGGAGCACACCCTGGGCAAGGGCCTGGAATTGGTGGCGCCACAGGTGGCGCTGCTCGGCC
+TGCTGTTCCTGCGTGGTCCGCAGACCCTCAACGAACTGCTCACCCGCAGCAACCGCCTGC
+ACGATTTCGACGACGTCGAGCAGATCCGCCACCACCTGGAACGCCTCGCCGGCCGTGGCC
+TGGCCGTGCACCTGGAGCGTCGCGCCGGGCAGCGCGAGGAGCGCTACATGCACCTGCTCG
+GCAGCCAGGCCGACCTCGAGGCCGCCGTGGAGGCGATGGGCAGCGACCCGGAACGCGCCG
+CGCCGGCCGCTCTGTCGGCCGATGCGGAAGCGCGGATCGCCGAGCTGGAGACGCGCCTGG
+CGGCGCTGGAGGAGCGCCTGGCCAGGCTCGAAGGAGGGGCGTGATATCGCGGGAGGGCGC
+AATCGGTGACATGCAGGTTCCGGCGGATAACCGCGAGCGGTTGTTCGCCCTACGGCCCGC
+AGTGACTTTGTGGGCGGCGCTGCCTGTCGGGTAGGGCGGATAACGCCAGCGGCGTTATCC
+GCCGATGCGCCGCCCCGCAAGGCGAACGCCAACCCAAAAAAGCCCGGCTATTGCCGGGCT
+TTTTCATGCGCGCGCGTCGGTGGCCGATCAGGCCTCCGGCTGTACCGGCACGTGGATCAG
+TTGCAGGCGCTCGCTGCTCCAGGCACGGGTGCTGTTGGTCAGCTCGATGTCGTTGTTCAG
+CTTGCGCCCGTAAGACGGCACGATTTCCTTCAGGCGTGCCTGCCACTCGGGAGTAGCGAC
+CTTGTCCTTGAAGGCCTTCTCCAGCACCGACAGCATGATCGGCGCGGCGGTCGAGGCGCC
+CGGCGAGGCGCCGAGCAGGGCGGCGACGGAGCCGTCGGCGGCGGTCACCACTTCGGTGCC
+GAATTGCAGTACGCCGCCTTTCTCGGCGTCCTTCTTGATGATCTGCACGCGCTGGCCGGC
+CTGCACCAGCTTCCAGTCCTCGTCGCGGGCTTCCGGGAAGTACTCGCGCAGCGAGGCCAT
+GCGGTCGTCCTGGCTGAGCATCAACTGGCCGATCAGGTACTGGCTGAGATCGAAGTTGTC
+GATGCCGGCGTTGAACATCGGGCCGATGTTGCCGCTGGTCACCGAGCCCGGCAGGTCCCA
+CAGCGAGCCGTTCTTCAGGAACTTGGTGGAGAAGGTGGCGAACGGACCGAACAGCAGAAC
+CGGCTTGCCGTCGATCATGCGGGTGTCGAGGTGCGGCACCGACATCGGCGGCGAACCCAC
+CGAAGCCTTGCCGTAGACCTTGGCCAGGTGGCGCTTGACCACGTCCGGGTTGGTGGTGGC
+GAGGAACGAACCGCCCACCGGGAAGCCGGCGTAGCCTTCGGCCTCGGGGATGCCGGACAT
+CTGCAGCAGCTTCAGCGCGCCGCCGCCGGCGCCGATGAAGACGAACCTGGCCTTGACGCT
+GGTTTCCTTGTCGCCATTGGCCAGGTCGGCCATGGTCACGGTCCAGGTGTTGTCGTCGTT
+GCGCTTGAGGTCGCGGACCTCATGTTGCAGGCGCAGCTTGAAGGTGTCCTTGGCCGACAG
+CGAGCCCACCAGTTGGCGAGTGATCTCGCCGAAGTTGACGTCGGTGCCGATCGACATGCG
+CGTGGCGGCGATCTTCTGCCCCGGCTCGCGGCCTTCCATCACCAGCGGCACCCACTGCTT
+GATCTGCTCGGGGTCTTCCGAGTACTCCATGCCGCGGAACAGCGAGCTGTGCTGCAGGGC
+GGCGTGGCGCTTCTTGAGGAAGGCGACGTTGTCGTCGCCCCAGACGAAGCTCATGTGCGG
+GACGTTGTTGATGAACGACTTCGGATCGTTCAGCACCTTGCGGTCGACCTGGTAGGCCCA
+GAACTGCTTGGAGATCTCGAAGTTCTCGTTGATCGCCACCGCCTTGCTGATATCCATCGA
+GCCGTCCGCGGCCTCGCTGGTGTAGTTCAGTTCGCAGAACGCCGAGTGACCGGTGCCCGC
+GTTGTTCCAGCCGTTGGAGCTTTCTTCGGCGACCTTGTCCAGGCGCTCGACCATCTCGAT
+GGTCCAGCCCGGTTCCAGTTCGTTCAGATAGGTACCCAGGGTGGCGCTCATGATGCCGCC
+ACCGATCAGGAGCACGTCGACCGGTTTTTCCGATTCGACGCTGTTTTTGGAGCAACCCAG
+CACGCTGACGCACAAAAGCATCAATAAGATTTTTTTCATGGATTTACCGCTAGAAAACGT
+GGAGAAGCGTGGATACGCACGACATGGCAGGTATTCACCGGGTGAATGATACTGGAACTC
+ACCCCCGATGTGAGTGCGTTCACATGCGGTGACATTTGCCTCGGCGTTCCGCCGAGAATA
+CCTGCCTTCCCTTTCTTGAACGTTTCAGCCACCGGGAAATAAATTCAGCGCCTGTATCGT
+TTCAGCGGGAACCCGGCGCGTGGATTTCCGCCGATTGGCGCATCCTGCGGATATACGCGT
+CGATTTCCCGCTCCGCGTCGAAACGGGTGAAATAGGGACCTTCCAGGGTCCCTTCGCGGG
+TGGAGAAGAAGTACTGCCCATTCACCGAACTTATGCGATCGCTGCGAAAGCGGGTGGCCG
+GGGTGGGATCGGTGGAACGTTTCCCCAACATGACGGCGACTCCTCGATAGCGGGCCAAGG
+TGTTTTCAGTGTAGGCGGGGGTTGGCCGGGCGGCAGGCCGGCGGACGAAAGGAGACGGAT
+TTCCAGGCGAAGGGTTGGGTATTCTATTTTTGGTTATAAGAAAATCTGAATTTATTCTTT
+TTAACGTCAGCCGGCCTTGGGCATAGTGGGCTCCAACACGAACAAGGAGTGACCCCATGA
+GCCTCAGACTCGGCGACATCGCCCCCGATTTCGAACAGGACTCCAGCGAAGGGCGCATCC
+GCCTCCACGAGTGGCTGGGCGACAGCTGGGGCGTGCTGTTCTCCCACCCCGCCGACTTCA
+CCCCGGTGTGCACCACCGAGCTGGGTTTCACCGCCAAGCTCAAGGACCAGTTCGCCCAGC
+GCGGGGTCAAGGTCCTGGCGCTGTCGGTGGATCCGGTGGAGTCGCACCTGAAGTGGATCG
+ACGATATCAACGAGACCCAGGACACCCGGGTCAATTTCCCGATCATCGCCGACGCCGACC
+GCAAGGTTTCCGAACTCTACGACCTGATCCACCCGAACGCCAACGACACGCTGACCGTGC
+GTTCGCTGTTCATCATCGACCCGAACAAGAAGGTGCGCCTGATCATCACCTACCCGGCGA
+GCACCGGGCGCAATTTCAACGAGATCCTCCGGGTGATCGATTCGCTGCAACTGACCGACG
+AGCACAAGGTCGCCACGCCAGCCAACTGGGAGGACGGCGACGAGGTGGTAATCGTGCCTT
+CGCTGAAGGACGAGGAAGAGATCAAGCGGCGTTTCCCCAAAGGCTACCGCGCGGTGAAGC
+CCTACCTGCGCCTGACGCCCCAGCCCAACCGCTGAGGCCGGATTCGTCCCGCCTGCATGG
+GCAGGCACGGCAGGCGGGACCTTTTATTCGACGGTGCGTGCCGTCATGCAACGCTGTTTA
+GCCACGAGCAGGGTTTTTGGCCGGTTTCGACCGGCCCTCTTTTTTATGTGCGCCAGCGCG
+TCGCCGCGACGCTTTTTATCCGCCATCCATTTCCGAAACCGGCTCTGACTTGCCCGCCAG
+ACGGGGAGAAGGCTCGCTCATCCACCTCCTTCCAGGAGCAGACGCATGATCGCCGCTCTC
+CGTCGCTGCCGGGCCTGGCTGGCCCTGCTCGCCGTTCTTGCCGTGTTTCCCGCGGCAGAG
+GCCGTCGCCCCCGCTGAAATCCGTCTCGACTATGCCTACTACGCCCCCACCAGCCTGGCG
+CTCAGGAAGTTCGGCTGGCTGGAGAAAAGCCTGGACGGCAGCGGCACCCGGGTGCGCTGG
+GTGTTCAGCCAGGGCAGCAACCGTTCCCTGGAGTACCTCAACGCCGGCAGCGTCGATTTC
+GCCTCGACCGCCGGCCTCGCCGCGGTACTCGCGCGGGCCAACGGCAGCCCGGTACGTACC
+GTATACGTCGCCAGCCGCCCGGAGTGGACCGCGCTGCTGGTGCGCAAGGATTCGCCGATC
+CGCAGCCTCGCCGAGCTCAAGGGGCGCAAGGTGGCTGCCACCAAGGGCACCGATCCCTAC
+CTGTTCCTGCTCCGCAGCCTGCACAGCGTGGGCCTGGACAAGAACGACCTGCGTATCGTC
+CACCTGCAGCATCCCGACGGCCGGGTAGCCCTGGAGAAGGGCCAGGTCGACGCCTGGGCC
+GGACTCGATCCACACATGGCGGCCAGCGAGTTGCAGGCCGGCTCGCGGCTGCTCTACCGC
+AACCTCGGCTTCAACAGCTACGGCGTGCTCAATGTCCGCGAGGATTTCGCCGAACGCCAT
+CCGCAACTGATCCGCCAGGTGCTGGCGGCCTACGAGCAGGCGCGCCACTGGGTGATCGGG
+CATCCCGACGAGGCCGCGCAACTGCTTGCCGAGGAAGCCGGCCTGCCGCTGGAAGTGGCT
+CGCCTGCAACTGTCGCGCACCGATTTCAGCCAGCCGCTGCCGGGCGCCGAACAGGTCGCC
+GCGCTCAAGGCCGCGGCGCCGATCCTGGCGGACGAGCGCCTGGTGCGGCCGGGCGTGGAC
+GTGCAGAAGGTGGTCGACGAACTGATCGCGCCGCAGTGGGCCGCCGAGGTCATCGGCGGC
+GCCCCGTTGGCACGCACGGAGCCCTGAGCCATGGTCAGCCAGAGCCTGCGACTGGCCCGG
+CGAGTCTCGCGCCGGGCGTGGCGACTGCGCGTGCCGGGCGCCTGGCGGGCCTGGGCCTTG
+CCGCTGCTGGCACTATCGTCGTGGGAGGCGCTGGTGCGCCTGGGCTGGCTGCCGGCCTAC
+CAGATGCCGGCGCCGAGCGGCATCCTGCTGACCCTGGTGGAACTGGCTCGCGGCGAGCTG
+TGGGGGCATGTCGGCGCGAGCCTGGCGCGGGTCGCCGCCGGCTTCGCGATCGGCAGCGGC
+CTGGCCCTGGTGGTCGGTACCTGGGTCGGTCTCAGTCGTCGCGCCGAAGCCTACCTGGAG
+CCGAGCTTCCAGGCCCTGCGGGCGATCCCCAGCCTGGCCTGGGTGCCCCTGCTGCTGCTC
+TGGTTCGGCATCGACGAGACGCCGAAGATCGTCCTCATCGCCCTCGGCGCCTTCTTCCCG
+GTCTACCTCGCGCTGGTCGCCGGGGTACGCGGGGTCGATCGCAAGTGGGTGGAACTGGGG
+CGGCTCTACCGTTTGTCGCGCTTCGCCCTGGTCCGCCGCATCCTCCTTCCGGCGGCGCTG
+CCGAACCTGTTCACCGGCCTGCGCGGGGCGCTCAGCCTGAGCTGGATGTTCCTCGTCGCG
+GCGGAGCTGATCGCCGCTACCCAGGGCCTCGGCTACCTGCTCAGCGACGGTCGGGAAACC
+TCGCGTCCGGACTTGGTGATCGCCGCGATCCTGGTCCTGGCGGCCCTCGGCAAGCTCAGC
+GATGGCCTGCTCCGCTCGCTGGAGCGCCGGGCCCTGCGCTGGCGCGACAGCTTCGACGGG
+GAGGGTGGCGCATGAGCGGCCTGCTCGACCTGCTGGAGATTCGCAAGGCCTATGGCGATA
+CGCGGGTGCTGGAGGGCGTGGCGCTGTCGCTGGCGCCCGGCGAGGTGGTCAGCCTGCTCG
+GCCCCAGTGGTTGCGGCAAGAGCACCCTGCTGCGGATCGCCGCCGGACTGGACGATGACT
+TCCAGGGCACTGTCGAACGCAACCCGATCCTCGGCTTCGGCCCGGACGGCGAGAACGGCC
+GCAGCGGCGGAATCGGCGTGGTGTTCCAGGAGCCGCGCCTGTTGCCCTGGCTGACGGTGG
+CGCAGAACGTCGGTTTCGCCGACGGCTGGCTGGAGGACGAGCACTGGGTCGAGCGCCTGC
+TCGCCGATGTCGGACTGGCCGGCTGCGGAGGATTGCTGCCCAAGCAACTGTCCGGCGGCA
+TGGCGCAGCGCGCGGCGATCGCCCGCGGTCTCTACGGACGGCCGCAGGTGCTGTTGCTCG
+ACGAGCCGTTCAGCGCGGTCGACGCCTTCACCCGCATGCGCCTCCAGGACCTGCTGCAGG
+ACGTGGTGCAGAACTACGAGATCAGCGTCCTGCTGGTCACCCACGATCTCGACGAGGCGT
+TCTATCTCGCCGACCGCGTGCTGCTGATGGGCGGCCGTCCCGGACACATCCGCCGCGAGT
+TCCACGTACCGCTGGCGCGTCCCCGCGATCGCCGGGCGGTGGAGCTGGCCTACTTGCGCG
+GCGAGGCCCTGACCGAAATGCAGCGGGCGCACGTGCTCTGAGGCAAGACCCCGAACCGGG
+TTTTTATATGCTTTATGGAATAAATAAATGAATAAAAAACATTTATTGGAATATGAGGCC
+GCCTGTTAAGGTCTATGCAACTTGGTTAGCAAGCCAAACGAATATTCTGTTTTCCGGTTA
+TAAGGAATCCCCCCATGCTCGTCGTTTCCATCGCCGGAAGTCCCAGCGTACGCTCCCGCT
+CCGGGGTGTTGCTGGAGCGTGCCAGGGACTGGCTGAGCCGTCGCGGCGTCGAGGTGGCCA
+GCCACCAGGTGCTGGATTTTCCCGCCGAAGACCTGCTGCGTGCCCGCCTCGACAGTCCGC
+CGGTACTGGCGCTGGCCGAGCAGATCGGCCGCGCCGACGGCCTGCTGGTCGCCACCCCGG
+TGTACAAGGCCTCGTTTTCCGGCGCGCTGAAGGTCCTGCTCGACCTGTTGCCCGAGCGCG
+CCCTGGAGCACAAGGTGGTGCTGCCGTTCGCTACCGGTGGCAGCAGTGCGCACATGCTGG
+CCGTGGACTATGCATTGAAGCCGGTCCTGGCCGCGCTCAAGGCCCAGGAGGTACTGCATG
+GCGTATTCGCCGTGGACAAGCAGATCGCCTACGCCACCGAGAGCGACCCGGCGCGCCTGG
+AACCGGTCCTCGAGCAGCGCCTGGAAAACGCCCTGGAAACCTTCCACCTGGCCCTCTCGC
+GACGGCCGCAGCCGATCGACCCGCAGTTGCTCAACGAGCGCCTGGTGAACGCCCGCTGGA
+GCATCTGATCCGTCCGCCGCCAGCGCACGCGCGCCGCGGCCCGATTGCACAACGCACACA
+CGACGACCTCACTGTTCCGTCAACGGCGCGGCAGGTTCGGCACCCACAACGACAAAGGAG
+AGCGCCATGCGCACCATCGCTTTGCGTCGTGGACTGGCGGCCCTGCTGGTGGCGGCCCTG
+TCCTACGGCGTTCAGGCCGACGAGAAGTCGGCCAACACCCTGCGGATCGGCTACCAGAAA
+TACGGCACCCTGGTCCTGCTCAAGGCCCGCGGCACCCTGGAGAAACGTCTCGCCGAAGAC
+GGCGTGAAGGTGCAATGGACCGAGTTTCCCGGCGGCCCGCAACTGCTCGAGGGACTCAAT
+GTCGGCAGCATCGACTTCGGCGTGACCGGGGAAACCCCGCCGGTCTTCGCCCAGGCCGCC
+GGCGCCGACCTGCTCTACGTGGCCTACGAACCGCCGGCGCCGACCAGCGAGGCGATCCTC
+CTGCCGAAGGACTCGCCGATTCGGTCGGTGGCCGAGCTGAAGGGCAGGAAAGTCGCCCTG
+AACAAGGGCTCCAACGTGCATTACCTGTTGGTCCGCGCCCTCGAGCAGGCCGGCCTGAAG
+TACAGCGACATCCAACCCGTCTACCTGCCGCCGGCCGACGCCCGCGCCGCCTTCGAGCGT
+CACAGCGTCGACGCCTGGGTGATCTGGGACCCCTACCAGGCCGCCGCCGAGAAGCAGTTG
+TCCGCGCGGGTCCTGGTGGATGGTCGCGAGCTGGTCGACAACCACCAGTTCTACCTCGCC
+ACCCGGACTTACGCGCAACGGCATCCGCAGGTGCTCGACAAGCTGGTGGACGAGATCCGC
+GAGGTCGGTGATTGGTCGCGGGCCAACCCGCAGCAGGTGACCGAGCAGGTCGCGCCGCTG
+CTCGGGCTGCCCGCCGACATCACCCTTACCGCGGTGAAGCGCCAGGGTTACGGCGCGCAG
+TTGATCACCCCGGCGGTGGTCGAGGCGCAGCAGAAGATCGCCGACACCTTCACCCAGCTG
+AAGCTGATTCCCAAACCGCTGAGCATCAAGGACGTGATCTGGACGCCACCGGCCGGCAAG
+GTCGCCAGCGCACCCTGAGCCCGTACCGCCCACATACCGACACGATCATCGCGCGGCTAC
+GCCACGCCGGCGCGCTCACCCTGGAGTCAATTGCGATGAGCCTCGAGATTTTCTGGTTCC
+TTCCCACCCACGGCGACGGCCACTACCTGGGCACCACCCAGGGCGCCCGTGCCGTCGACC
+ACGGCTACCTGCAGCAGATCGCCCAGGCCGCCGACC
+>NODE_8_length_39997_cov_62.8364_ID_15
+GGGACAAAAACGCCGTGTTTATCGCAGCTTGGTTAGCTGAATTCCAAAACTGCACGGACT
+ATTGTCTTATGTCAAATGCTCTAATTACGCCAGAGCGAATTGCTCTTGCGCCGCGAGCAG
+GCCGCTGAGCTGCTCGGCGGTGAGCGGGTAGGAGAGCGCGTAGCCCTGCCCGAGCGGGCA
+GCCGAGTTGGCGGGCGGCCTCGACGACCACTCAACCGCTCTTATCTCGCATCCTGCCCCG
+CAGGATGCACCGCACTACCCTTCGCCCTTCACGCCTCGTCTTGCATTCTGTTGATTTTGA
+GCAGCATCACAAATGTAGACACCCCCGTGCCCATAGCACTGTGGAACCACCCCACCCCAT
+GCCGAACTGGGTCGTGAAACACAGCAGCGCCAATGATACTCGGACCGCAGGGTCCCGGAA
+AAGTCGGTCAGCGCGGGGGTTTTTTCGTTGCGGGAGTAGCTCAGCTGGTAGAGCACTACC
+TTGCCAAGGTAGATGTCGCGAGTTCGAATCTCGTCTCCCGCTCCATCATCCCCCCTTCGC
+CTCTTCCGAGGTGGAGGGGCTTTTTTGTTGGCTTGCCGCATTTCTATGAACCAGTGCGGC
+ACAATAACAGCTGTGTTTGAATTTGAAATCAAGCAGCGTGATGGACGTGCCCGCACGGCG
+ACGTTCCAGACGCCGCGCGGAGCGGTCACCACACCTATGTTTATGCCCGTCGGCACCCAG
+GGCACCGTAAAGGGCATCAGCCCACAGGAACTGCTGGAAATCGGTTCGCAGATGATCCTG
+GCCAATACCTATCACCTGATGCTGCGGCCAGGAGAGCAGCTGGTCAAGGCGCATGGTGGT
+TTGCCGGGATTCACCGCCTACCCAGGCCCCTTTCTGACTGACTCAGGCGGTTTTCAGGTC
+ATGAGCCTGGGGCACATGCGCAAAATCAGTGAGGAAGGGGTCGTGTTCAAGAACCACCTT
+GATGGCAGTCGCGTCGAGCTGACGCCGGAGCGCAGCATTCAGGTGCAGGAGGCCCTGGGA
+GCAGACGTCATCATGGCCTTTGACGAGTGCCCTCCCTATCCTGCCGAGCGGCCTTACATC
+GAGGCGAGCCTGGACCGCACGGTGCGCTGGCTCGAGCGCTGCCACGCGGTGAAGACTAAA
+GATGACCAGGCCCTCTTCGCCATCGTGCAGGGTGGCGTGCATGAGGATTTACGTCTCAAG
+AGTTTAGAGGCCACCCTGCCTTTCGCCACGCCTGGGTTCGCGGTCGGCGGCCTGGCGGTC
+GGGGAAAGCAAGGAAGAGATGTATCCGGCGGTGGCGTTTACAGCCGGCCGTCTTCCCGAA
+AATAAGCCGCGTTATTTGATGGGTGTGGGCCACCCCGAAGACCTTGTGGCAGGAGTGGCA
+CTGGGAATCGACATGTTCGACTGTGTGTATCCGACACGGACCGGGCGCTTCGGCTACGCG
+CTGACGGACGACGGACGGCTCAACCTCAACTCCAGTGCGCCGCGCACCCAGCTCCAGCCC
+ATCGACGCGGAATGTGACTGCTACGCCTGCCGTCATTACACCCGCGCTTACCTGGCGCAT
+CTGCTGAGAGCGGAAGAAATGCTGGCTCCGCGCATGTTGTCGCTGCATAACCTGCGGTAT
+CTGCACCGGTTGGTCGAGCGAATGCGAGTGGCGATCAATGGGCAGCAGTTCCATCCCTGG
+GCAGCAGACTGGAGCGAGCGTTATTTTCACGGCAATGTCCCAGGCTGGTTCACCAGTGCG
+TTTGAGCGCAGTACCCAGTCCGAAATTTAATAAGACGGACTCGCTGCGGCCTTTTCGGCG
+TCACTTAAACGGTCAAAGTTGAAAATGAGAAGAAAATCTGATGGTCAACTGACGGAGAAG
+GGGCGAAAACAGTTTATTTGACGGTATTTAGCTCGCTCTTAGGGTTGACCCGCCCATCTT
+CATGCTTGTATCATCTGCACGATCTGCCCTCTTCTGTAGCCACAGGCTGCGAAGGGTGGG
+TTGCGCGAAGAAGGCGGAGTAAGGCCCAACTTCTCCTGGGAGAGGAAACATGGCAACTCG
+CCCCATCAACATCCTGCGTGCTGGAAACGCTGCTCGACGCGCACTGAGATTGGGGGTTCC
+CTATGAAGAAAAGTCTGATCGCTCTTACCACGGCGCTGTCGTTCGGCCTCGCTGCCGCCC
+AGACCGCCGCACCGGTGAGTGCACCCCAGGTTCCCGCCCTGACCGACGTTCCTGCCGGCC
+ACTGGGCGAAGGACGCCATTGACCGTCTAGTGAGCCGCGGCGTCATCCTGGGCTACCCCG
+ACGGCACGTTCCGTGGCACCCAGAACCTGACCCGCTACGAAGCCGCCATCATCATCGCCC
+GTCTGCTCGACCAGATGCGCGACGGCGAAACCCCCGCTGGCATGACCGCCGAGGACATGA
+CCGCGCTGCAAAACGCCATTCAGGAACTGGCCGCCGACCTGGCCGCCCTGGGCGTGCGCG
+TCAGCGACCTCGAAGCGAACGCCGTCAGCAAGGACGACTTTGCCCGCCTGGAAGCCCGCA
+TCGAAGAAGTGGCGGCTGCTGGCGGCGAGCAGGGCGCGACCGAAGCCCTCCAGGGCCAGA
+TCGACGACCTGACCGCCCGTGTGGACGAGTACGACGCGCTGCGTGCCGATGTCGACGACA
+ACGCCAGCAGCATCGCTGCCCTCAACGACCTGACCGTGCTGCTCAACCAGGACATCCTGG
+ACCTGCAAGACCGCGTCAGCGCCGTGGAAGCCGCGCAGGCCGACTTCGTCCAGCGCAGCG
+ACTTCGACGCCCTCGGTGGCCGCGTGACCACCGTCGAAACTCGCGTCGAAACCGTCAACA
+ACTCGCTGACGGGCCGCATCGCTGCCCTGGAGCGCAACGCGTTTAGCGTCAAGCCCAGCC
+TGACCATCGGCTACAGCGTGAGCCGCACCAGCCGCAACTTCGACGTTGACCGCCTGTTCC
+CCCTGAACGCGGACGGCACCGTGGCCAACAACGCCTTCACCAGCGGCGGCATCGACACCG
+ACACCGGTGCTCAGCGCCGTGACTTCGGTGACTTCGGCAACGCCTCTGACCCCGTGGTCG
+CGGGTGCGGCGGGCCTGTACGGCTTCGCGGACGGCGTGAGCTACACGGTGTACTTCACCG
+ACGGCTCCACGGCGACCTTCGACGGCCTGAACCCCGCCGATTACAAGGTCCCCACCGGGA
+AGGTCATCGATACCACCAAGGGTCGCAACGGCTTCGGCTTCAACAACCTGGCCCGCTACA
+AGGAAGGCAGCACCGACATCGGTATTAGCCTGGGCTTCGACACCAGCGGCCAGTTCAGCC
+AGGTCACCAGCGGCACCGGTGGCAGCCTGTTCAGCACCGCGGGCCGTCTCCAGGTCAACC
+AGATTGACCTGAACTTCGGTCTGGTCACCGGCCTGCCGAGCGACGCTTACGTCGACACCA
+ACGGCAACGGCAAGAAGGACGACGGCGAGGCGACTGGCCGCGGCACGTACCTCGGCAGCG
+GCGGCACGGCGGCCATCCTCCGCGATCCCGCTGGGAACGTCTACCGCCCCGTGTTCTTCC
+GCTTCAAGAACGCCACCACCCAGTTCAGCGTGGGCAACAACCCCGTTATCGTGACCTTGG
+GCCAGCAGCAGAAGTTCTACTTCAGCGACTACGTCTTCGACAACAACTACGATGGCCGTG
+GCGACGGCTTCACCGTGACCGTGGACGGCAGCAACGTGCCCGTGATCGGCGCCTGGAAGC
+CCCAGATCAAGGGCGTGTACGGCAGCCGCAGCGGTCTCGACGGCACCGCCGAAGCCGGCT
+ACGGCGTGTACTACCGCGGCGTGCGTGCGCAGATCACCCCCGTCGGCACCCTGACGGCGG
+GCATCCACTACGCGCAGGAAGGCCGCGACATGTTCGGCGCAGCTCAGAACACCACCAGCA
+CGCCTTCCGACGTCACCACCTACGGCGCCGACCTGCACGGCAAGGCCTTCGGTGTGGAAC
+TGCACAGCGAGTACGCCACCAGCCGCGTGCGCCCCAACACGGCCAATGCTGCCGTTCAGA
+CCAGCAACGCGTTCTACGCCCGCGTGGCGACCCGCAAGGACAACCTGGCGTTCGACCTGA
+ACACGCCCGCCGCCAAGTTCGGCAACGACACCTTCGGCGTGTCGCTGTACGACCTGAACT
+ACCGCAAGATCGACGCGGGCTACAACAACGTGGCTGGCATCAGCGAGTATGGCTACGGCT
+CGTACAGCCGCACCTCGGCCCAGAACATCGCCTACAACCCCGACACCGGCGTGACGGCTC
+CCTTTGCCAACCTCGACCGTCAGGCCTACACCGACGCCAATAACGACGGCACGTCTGACC
+GCAACGCTGACGGCACCGTCGTTGCAACCAACACCAAGATCGGTCAAATGGGCTTCGGCG
+TGAAGGCAGCGGCCAACCTCGGTCCCGTGGCCATCGGCGGCTACTACGACACCAGCACCG
+GCGCCAACGGCGACAATGCCAACCGCATGACCGAAGCGGGCGGCTCGGCCAAGGTGGCCT
+ACAGCATCTTCTCGCTGCGTGGCACGTACAACACCCTGGACAGCAACCGTCCCCAGATCT
+ACCGTGACGCCGCCGGCACCCAGATCATCGGCGACGCCAAGGTGCGCCGCTACGCCGTGC
+AGGCGGACGTGACCCCCGGCCTGGGCCTGTTCGTGGGCGCTTACTACCGCGACGTGAACG
+TCAACGGTGTGCGCTCGACCACCGACCGTGGTCTGCTGGGCCGCGGCTACCTGGCTTCCA
+GCTTCGAGCCCGGCGTGGGAAACAATGCCTACCGCACCGGTCTGCGCTGCGCCGACAACA
+ACTTCGGCACCGGTACCCGGGACATCGACGGTGTGGGCGGCGTGCTCAACCCGGCGGTCA
+ACCTCGACCAGAGCCGCACCGCCACCTGCTTCACCTCCTACGGGGTCGAAGCGGGCCACG
+CGGGCGACAACGCCAACGCCCTGGTCAAGGACCTGTTCTTCCGCGTGGGCTACTCGCGCG
+TGTACGTGCCCACCACCGCCACCGCGACGACGGGCGATTTCAGCGGCTCGGTGACCTACG
+GTGACGCCCGTTACGACCGCAAGGTCGGCGTGGCGAACGTGCGCCTCGCGGGCTCGTTCT
+CGACCACCAACACCCAGCTCGACAGCCGTCCTGCCGGGACCCGTGGCGCGGTCGGCCTGA
+TTGTGCGCACCGATCCCCTGGAAAACGTGCCCTTCCGTCCCCAGTTCAACGGTCAGGTGG
+GCTACTACACCGCCGACAACCGTGTGGCCGCTGGGAACTACAACGCCAACGCGACCAAGT
+ACGGCGCGGGCGTGGTCCTGAACGACTTCCTGCTGCCCCAGACCAAGATCGGCGTGCGCT
+ATGACGGCTATATGGCTCAGAACCGTCAGTACACCCCCTTCGACGGCGACGGCACCCAGG
+GCTACTTCAGCGACGCCAACAACAACCGCCGGACCAACCTGAACGGCGTGTACGTGGAAG
+GCGCCTACCAGGACCTGATCTTCAGCTACGGCACCTACACCCTGAGCCAGAAGGATCTCA
+ACGGCGTCGAGTACGGCAGCGGCATCAACAACGGCCAGCCCGCTCGCGGCCAGACCTTCA
+AGATCAGCTACAAGGTCAACTTCTAAAGCCCCTAGTTCCCGGCATTGCCGGGCAACGGCC
+CCCGCTTCGGCGGGGGTTTTTGTTGTTCTGTAGTTAGTTCCGGTGCGGCGCGGCCAAAGT
+CGGTAGACTGACGCCATGCTCGCTGTTTTTGGACACCTCAACCCCGATACCGACGCCATT
+TCGGCGGCGATGGTCTACGCCCGGCTGCTGACGCGGCAGGGCACCGAGGCCCAGGCTTAC
+CGGCTGGGCGAACCGAACTTTGAGACGGCCTATGTGCTGCGTGAACTGGGCCTGGAAGCG
+CCGCCACTCCTGACCGAACTGCCCGCCGGCAGCAAGGTGGCGCTGGTGGACCACAACGAA
+AGCGCGCAGTCGCTGCCCGCCCTCGGCGAACTCGACGTGACCCGCGTGGTGGATCACCAC
+AAGCTGGGCGACCTGACGACCATCAACCCGCCCTACCTGCGCTTCGAGCCGGTAGGCTGC
+ACGGGCACCATCCTGCTGAAGCTGCACCGCGAGGCTGGCCTGAGCGTGGAACCCCAGGAC
+GCCAAGCTGATGCTGAGCGCCATTCTGAGTGACACCCTGCACTTCCGCAGCCCGACCACC
+ACCCAGGACGACCGCGACGCGGTGGCGTTCCTGGCCCCGGTGGCCGGGGTAAACGACGTG
+GAGGCCTACGCACTGGCCATGTTCGCCGCCAAGAGCGATCTGGGCAACACGCCCGCCGAG
+ACTCTGCTGCGGATGGACTACAAGGTCTTTCCCTTCGGGGACCCTGTGCAGCCGCAAAAC
+TGGGGCATCGGCGTGATCGAGACGACCAACCCGGCCTACGTGTTCGGGCGGCAGCAGGAA
+CTCCTCGCAGCGATGGATCAGGTCAAGGCCGAGGACACCCTCTCGGGCATGTTGCTGAGC
+GTGGTGGACATCCTGAACGAAACCAACCGCACGCTGGTGCTGGGCGCCACCGAGGCCAAA
+GTGCTGCGCGAAGCCTTCGGCGCCGAAGCTGAGGGACAGGTAGCCGATCTGGGCAACCGC
+ATCAGCCGCAAGAAGCAGATCGTGCCGACGCTGGAAAAATACTTCGCGCCCGAAGCCTGA
+GCGGGCTCTTTCAACAGGGGAGACGGGGAGCACCTCGTCTCCCTATTTACTTGCACAGTC
+CAGAGCGGCGGTATGCTCCGCGCGTGACGCAGGACACGAATGTGGAATGGCTGTTCGCCC
+GGCAGCGGTTCGGAGTGCACCCCGGCCTGGACCGGGTGCGCGAGCTGCTGGCCCGGCTCG
+GCGACCCGCAGCGGCAGTTCGGGGCCGTGCTGGTCGGCGGAACCAACGGCAAGGGCAGCA
+CCGCCGCCACGCTGGCCGCCATGCTGCGGGCGGACCGCAGACGCACCGGCCTCTTCACCA
+GCCCGCATCTGACCCGGCTGAGCGAGCGTTTCGTGGTGGACGGGGAGGAAGTCTCGTCGG
+CGCAGGTCACGGCAGCGCTGGCCCGCGTGCGCCCGGTGAGCGAAGCGGTGGAGGCGTCTT
+TTTTTGAGGTGGTCACTGCGCTGGGGTGTGTGCTGTTCGCCGAGGCCGGAGTAGAAATCG
+CCGTGATGGAAGTCGGGTTGGGAGGACGGCTGGACGCCACCAACGCGCTGGAGCCCCGGC
+TGAGCGTGATTACCAATGTGGCACTCGACCACACCGCCATCCTGGGCGGCACCGTCGAGC
+AGATCGCGGCGGAGAAGGCGGGCATTCTGCGGGCCGGGCGACCTGCCGTGACGGCTGCCG
+CGCCCGCCGTGCTGCCCGTGCTGGAGCAGCGGGGCGCCGATCTCTGGGCGCTGGGTCGGG
+ACTGGACGGCGCAGACCCGCAGCCTGGGCTGGCAAGGTACGGCGGTCGACGTGCAGTGGC
+CCGGCGGTGCGGCGCAAGTGCAGACCCCGCTGCTGGGCGAACATGGGGGCCTCAACGCGG
+CGCTCGCGGCAGTGGCGGCGGCGCGGCTGGGCGTCTTTAATGAAGCCATCCGGCAAGGAG
+CCGCGCAGACCCGCTGGCCGGGGCGGTTGGAGGTTGTCCCCTGGCAAGGGCGGCGGGTAC
+TGCTAGACGGGGCCCATAACCCGGCGGGAGCACAGGCACTCGCGCAGGCGCTGCGTCCAT
+TGCTGGCGGCGAGTGGCCGTGCCCAGTTGCCCATCATCTTCGGGGCAGCGGAAGACAAGG
+ACCTGGGCGGGGTCGCCGCAGAACTGCTGCCCCTCGCCTCACGGGTCATCCTGACGCGGG
+CTGCGCTCAGTCCCCGGGCCGCCGACCCGGCGCAGCTCGCGGCTCTGTTTCCAGGCGTGC
+CATTGGAGTTGACCCAGACGCCCGCCGAGGCGCTAGCAGTACTGCGGTCTGACGATGACC
+TCGTCCTTATCTGCGGGAGCCTCTATCTGCTCGGCGAACTGCGTCCTTTGCTGCTGGGCG
+AGCAGTCGGAAGGCCACGAACGCTGGCAATAGCCACAGCAGCGGCCAATTTCTGGTTTCG
+AAACAGGAATAAGGCAAGTTGACTGCCCTCATTCTGTATTGACCGTAGCAAGGAGCGGTG
+TTACACTCCGACCAAGGGTGCCTGATTCTGCCCACAAGCAAACGCCAGGCGGGTTCCACA
+TCATCTGTCTCTCGGGCATCCCCGACGGGTGACGGGTGGTCCGCCGCAGCCCAGGAGGTG
+AATGACATTGAAACTGCACGAACGACTTCGTGAATTGCGCAGCGAACGTGGGCTGCGGCT
+CAAGGACGTGGCCGAGGTTGCCGACATCAGCGTGCCGTACCTGAGCGACCTGGAGCGCGG
+GCGCACCAACCCCAGCCTCGAAACCCTCCAGACCCTCGCCGGGGCGTACAACATCACGGT
+TCACGACCTGCTCGAAGGGGTCGAGTTCTACGGTGAATCCACCGACGGCGCCCTGCCCAA
+GGGCCTCGCGGACCTGATCGCCGACCCCACGCTGGGCCCGCAGATCACGCCCGACTGGGT
+GCGGACCCTCTCGCGCATCGAGTTGCGTGGCAAGCGCCCGCGCGACAAGCAGGACTGGTA
+CGAGATCTACCTGCATCTCAAACGCATCCTGAACTGATTTCCGCACAACTCCGGCCCCGT
+CGCCGGGGTTTTGTTCTTGGGAGATTCAAAAATGGCGCCCCCTCGCTGACCTTTCCGTCG
+AGGGGGCGCCGTTCTGTGAGGAGGCGTGTCAGGTCAGCGGTAAGACCTGCCGGTGCTCGG
+CTTCTCGCCGTTGCAGCACCAAGGTTCCCGCTCCCCAGGCGCCGCCGACGAGGGCGAGCG
+CGAAGGCCAGCGGACTCCAGCTCAAGCTGCCCGCAAAGAGGCTGATGCCCAGGAAAGCGC
+CGACCGTATCGGGCACTGGCAGGCGCAGGCGGCAGGCGAGGGCGCGGCCCAGGTCGTAGA
+CGCTGACGCTCAGGCCAGTGGCGATCAGCAGCCCCGCCAGCGCAAGCACCAGCAGCGCCG
+GGCCGAGCAGACCCGCAAAGGCCAGCGCTAGTGCCGGCAACAGCAGCGCCGCGAGCAGCA
+GCACGCCGAGCGCCAGCGTCCGCATCGGCGCGTGCCGTTGCTGCCGGGCGAGATCTGGGG
+CTGTGCCTGCCACGAAGAGCAGCAGCAGCAGGCCCGCCGTGAGCGTCACGAAAATCTGCG
+GCCACGCGGCGGCGCCCAGCCAACCGAGCAGGGGCCGGAAGGCCGCCGCCGTTGCCAGCC
+GCACCCCCTGCGGCGCCGGCAACGCCCCGACCTCAGCGGCCTCGCCGGGGGTGCGGCCCA
+GCACCGCGCTCATTTCGCCGCTGACCTGGGCGCCGGGCGCCTGTTTGATGTCGCCCAGCA
+GAGTGACCACCCGGCCATTGACAGCGGCGTCGGGCGCCAGCACCACGTCTCCGCCGATGG
+CGACGATATTGCCCTCGACGGGTCCATGAACCTCCACCGGGTGGCCGAAGCTCAGGCCGG
+GTTCGCCGTTGACCAGGCTGGCGAGCGGCGGCAGCGACAGCGCGCCGGCCAGCACGAAGG
+CCCCGGCCCCGAAGCGCCGCACGGCGGGCGTGGGCATCCAGGTGACCAGCGCACTCGTGA
+GCAGCAGCAGCAACAGGCCCAGGCCAGCGACGGGTGCCACGTGCTCCAGCACCGTCTGCA
+TGACCAGGGCGCCCGCCGCCAGGTTGGGCCACGCCGCCGTGACCGTCAGCAGGGTGAGTC
+CGGTCAGCAGCCCACCGACGAGCAGCAGCGGAGCGTGGCGGCTGTGGGAGGCAGAGACGG
+ATCTGGAAGCTGGGACTTGGGCTGGTGGCGTCACTTCCAGTGAAGGTGGTGCGGAAACAA
+CAGCCTCGGCCTGCTGCCCCTCCTGCGCGATGCGGCCCGCCAAAGATGCCGCCAGCGAGC
+GGGGCGGCGGGGGCACCGGCGCCTGCTGCAACACATTTCGCGTGCGGGCGTCGCTGGCAA
+TCTCGGCAGCTAAAGATGCGGCGACAGGACGTAGCATTGGAGGCGGCGTCTGCAACAGCG
+CGGCGGCCCGCAGGTCGCTGAGGACGGCAGGTGCCACCGAAGCAACTGAAGGCAGAGGTG
+CGGCCCCCAGTTGCCGGGCCAGCGCGATGTCCTGCGAGACACTGGCCGCGAGTGAACGTG
+GGAGGGCTGGCGGAGCAAGAACACCGCGCAGGGTGGCACTGCTGGCAATTTCACTGCTCG
+TTTCGGCAGCCAATTGGTGAGCGAGTTCAGGTGCCAGCGTCGGCGCGGTGAGCTGTTTCC
+CCAGGCGAAGATCGGCCAGCACCGCGTCGGCCACACTGCGGGGAGCAGGCGGATTGGGGC
+CGGTCAGCAGCGAGATGGCCCGGTGCAGTGAGCGCCGCGCCTCCTGCACCTGCGGGTCAA
+GGCAGGCGGCGTCCAGGGCGGCCTGTTCGTCCGCGCTCAGGTCGACGTCCGCCTCACGGT
+GCAGCAGCGCCCGCAGCTCCGGTGTCAGAACCTGCGTCCATTCTGGTGTGTTCCACCCCC
+CCTCTTGCCGTGCGCCCATCGTCGGTCCCTCCTCGTCCCTTCCTTTACGTCAAATCCGCC
+TGCAAAGTTCCCGGCGGTGGGAGAACGGTCGCCGGAAATTATCTAGACAAATTAGGGATT
+AAGGCTGGGGCGGACGCTCGGCGGCCTGGTAGTCGCCGCTTTTGCCGCCGGTCTTGGACA
+GCAGCCGCACGCCGCTGACCTCGATGGCCTTGCTCGTCGCCTTGAGCATGTCGTAGACGT
+TGAGCGCGGCCACCGTGACGGCGGTGAGCGCTTCCATCTCGACGCCAGTGGGGGCAGTGG
+TTTTGACGAGGGCGGTGATGTGGATGCCCGCGTCTTTCAGCGTCACGTCCACCTCGGCAC
+TCGTGACCGGAATCGGGTGGCACAGAAAAATCAGGTCGGCGGTGCGCTTGCTGCCTGCGA
+GCCCGGCGAGGCGCGCCACGCTCAGGGGGTCGCCTTTGGGCGTTTGCCCGGCGAGCAGCG
+CGGCCCGCGACTCGGGCGGGAGCAGCACCCACGCTTCGGCGCGGGCGGTGCGGGTGGTGG
+GCGCCTTGGCCGACACGTCTACCATGCGCGGCTGGCCGCCGACGAAATGGGTGAGCTGCG
+GGGCGTCGCCTTGCGGGTCGCTCATTCGTCGGGCAGCTCCAGGTCTTTCAGGCGCGCGAA
+GGGGTTTTGCTTGGCGTGGCTGCTCCCCTCGGGCGAACCGAGTTCGACGACCTGCTCCTC
+GATGGGCACCTGGGCGCTGTGTTCGCAGGGGCCTTCGTTGAGGTCGTGGCCGCAGACCTG
+ACACAGGCCCTTGCACGCGGGGTCGTGCAGCACGCTCAGCGGCGCGGCGAGCAGGGTGCT
+TTCGGCCAGGTACGCGCTGAGGTCAAGGTCGGGATTGCCGAAGACGAGGACTTCCTCGCC
+AGTTTCGGCTTCTTCGATGTAAGGCTCCTCGGCGGAGGGTTCGTAGCGCATCAGCGTGCC
+GAGGTCGATGTCGAGCGGCACCTGCACCTCGCGCAGGCAGCGGGCACATTCCATGACCAG
+CGTGGGCGAAAACTGGCCTTGCAGGTACATCTCGTCGCCGCCAAGCGAGTTGATGTCCAC
+CTCAAAAGCGGCAGGCTCGGCAAAACGCAGGGTTTGCGGCTGCTTGCCCTGAAGGTACTG
+GAGGTGGTCGAGTTCGCCCTCGGCGTGCGCGTCGTCGGCGGTTCGCAGCAGGGCTCCCAG
+GTGAATGCGGGGTTGATCGTTCATGGGCGCCATGATAGAGGGCTGGCCTGCGGGCAACTG
+CGGCGGCGTGGGGGTTGCGCCCTGGTGAGCGATACGGGGGAAGGGCACCGCTGCCGGTGT
+TCCGTTCAGGGTTCATCTGTCCTGCCCGGCGCGGCGGCATACTGCGGGGCAGTGCTCGCC
+CCCTCCCGTGACCAGGCCCCTGTGACTGACTTCCTTTCCTCTACCCCCCTGACCGCCTTC
+CGGCGTGCGCTGGCCCGTGTGCTCGCGCTGCTGGTGGGTTTCGGTCCGCTGGCGGCGCAC
+GCTCAGGCGGCGGGCACAGCGGCGGTGAAGCCCCTGGTCGCCACGGTCGCTACGCCGTCG
+GCCTCGCGCCCAAACGCGGCGCTGCGCTGGACGCGGCTGGGGAACCCCAGGTCGCCCTCG
+CTGCTGCAAGTGCCCGCCGATTGCCAGGTGCGCAGTTGCCCGCTGGTGGTGGTGTCGCAC
+CCCCGCGCCCAGGACGCCGCCCGACTGCGCGACAGTGCCCAGGTCGGCAAAATCTCGCAG
+GCGCTGCTGGCCGCCGATTTCGCGGTGCTGCTCAGCGGCGACGGCGGCGTAAACACCTGG
+GGCAGTCCGGCAGCGCTGCGGGAAGTCGCGCAGGTTCACCGTGAGGCCACCAGCCGATTT
+CGCTGGAACAGCCGGACCTACGCCCTGGGCCTGAGCATGGGCGGGCTCCTCTCGCTGCGC
+AGCGCCCTGCCCGATTCGCCCTATACCGTCCGGGGCGTAGCTCTTATTGACGCCTGGGTC
+AGCCTGCGTGGCGCGTGGGGCAGCGCCCTGTCGCGCCAGCGTGAAATCGGCAAGGCGTAT
+GGCCTGACCGTGCCGCCCACCCCCACCCTCGACCCCCTGCCCCTCGCGCAGCGCCTGGCT
+CCGGTGGCGCCGCTGCCGCTGTTTCTGGCCTACAGCCCCACCGACACGGTGGTGTCCTCG
+CGCAAGAATGCCGAACTGCTGATTCCCAAGGCCGAACAGGGCGTGAGCGAGATCGTGCGC
+CTCGACGGGCCCCACCTCGGCGGCAACCGCTTCTCACCGCAGATGATTGCCCGGCTGGTC
+GGCTTTTATCAGGGCCTGGAGCAGCGCGCCATTGCCCGCCAGCACAAGGAATTTCCGCCT
+GGTCTCCCGGCTCCGGCGGTGCAGCGGGCTCAGACGGAGACGTCGAAAAGCTAAAGGCGA
+GGGGGCAGAGAAACCGACTTCTCTGTCCCCTCGCTTTTAATGGGTTTATACGGATTTCGT
+CCAATTCCCCCACCTCCGGAACGGCACCGGAGGCGGGACCATTTCCCGAAATCCTTTTTA
+CTGCTTCTCACTCCGTTCGGATGGAATCCCCAGAACCGGGGGATCCCATCGCAGCCGGTT
+TACATCGCCGCCGGAATCTCGATGCCGATGAGGTCCAGGGTGTCCTCGAAGGCTTTGCGC
+AGCCGCACGATCAGCGCCAGCCGCGCTTCCCGCAACCCTTCTTCCGATTGCAGGACGTTG
+GTGGCGGGTTTGCCCTGCTTGGTTTTGGCGTTGTACCACGCGTTGAAGGATGTGGCGAGA
+TCGAGCGCGTACTGCGCCACCACGTGCGGCGAGTGGATGCGGGCGGCCTGCGCGGCGACT
+TCGGGCAGCTTGGCGATCTGCTTGGCGAGCACGAGGTCGATGTCGGGCAGCGCGTCCCAG
+TCGGCCCCGGTGCCGTCGGTGGCATAACCGGCTTCCTCGGCCTTTTTCAGGATGTTGGCG
+GCGCGCACGGCGGCGTACTGCACGTAGGGCGCGGTGTCCCCGTTCAGCGCCAGCGCCTGC
+TCCCAGCGGAAGTCGATTTTGCGGGTCGGCTCGGCCTTGAGCATGGCGAAGCGGATGGCG
+CCCAGGCCGATGCGCCGGGCGATTTCGGCGGCGTCCTCGCGCGCGGCCAGGTCGGGATTG
+ATGCCCTGCAAGACGCTCAGCGCGCGCTTCTGGGCCTCGTCCATCGCGTCGTCGGCACTG
+ACCGCGATGCCCTTGCGCCCGCTGATGGTCTGGCCTTCCAGCGTCACGAAGGCGTAGGAG
+AGGTGGATGCTGCGCTCCTCCTTCTCCTGCTCGCCCGCCACACCCAGCGCCGAACGCACC
+ACCGTCTGCGGGTGGTCCTGGCGCGAGTCGATCACGTTGATGACCTCCTGCGCGTGCCCG
+AAGCGCCGCTCATCGTCGGGCTGGCCGTCCGGGGCACTCGTCCAGATGGTGTTGCCTTCG
+GGGTCCTGCATGAAGGGCTTGAATTTCATCCCCTCGAACAGGCCGAATTTCCAGAACTGG
+TAGCCGATGTCCTTGGCGGCGTACATGGCGGTGCCGCCCGAGCGCACGAGGACCACGTTC
+GGTTCTTCCAGCCCCGGCATAAATTCCGACACGTCCATGATGAACGCCCCGGCGTACTTG
+CCCTCGGTGGGGCGCGAGGTGTACCTGCTGCCTTCCAGAATGTTCATGGCCTGCGCCAGA
+AACCCGCTGCCCACCACGTCGGATTCCCAGTTCAGCAGGTCGTAGCGCGCGCCGAGGCGA
+AAGCAGGTCTGAAGCTGCGCCTTCACCGTCTGCTCGACCAGGGGCCGCAGCTCCCCGGCT
+TCGAGCTTGTGCATGATCTCCATGATGCCGCTTTCCAGCTCGGGCTTCTGGGGGTCGGCG
+TTGAGCTGCACGTAGCCTTCACCGAGCCACTGGTCGTACTTCTGCACGCCGTCCCAGACG
+CGGCCGTAATGCTGGGTGGCGAACAGCGACTCGGCGGCCTGTCGCCCGGTGTCGTCGATG
+TAGTTCTGTACCTCGACGGTGTGCCCCGCCGCCCGCAGAATCCGCGCCATGGAGTCGCCC
+AGCACCACGTTACGCAGGTGCCCGACGTGCAGCTCTTTGTTGGGGTTGACCGAGGTGTGC
+TCGATGACGACCTTGCCCTCGCGCTTGGGCAGCTCGAAGGGACGCTCGACCACGCCGCGC
+ACGAAAGCGCCCGCGTCGAGGAAAAAGTTCAGGAACGGCCCCGTGGCCTCCACCCTGCGG
+ATGCCGGCGGGCAGCACCACCGTCTGCGCGAGCTGCGCGGCGATCTGGGCGGGGTTGCCC
+CCGGCCGCCTTCGCCATCTGGAAGGCGGCGGGCGTGCCGTAGTCGCCGGGTTTATTGGCG
+GGCGTTTCCTGAATGGCGGCGTCGACGGGCATTCCCATCTGGTGCGCGGCCTGCTCGACG
+GCTGCTTTGAGTTGGGCCTTCAAATCCATTCGGGCAGTTTACGGGGCGCGGGCGCTGACA
+GGGTCACGGGGCAGGAAAAGAGGCCATGCGCCACTTCCCGCCCCTGTGCTGAAGGCCAAA
+ACTGTCCGGAATCGGGTATTATACGGCTTTAATCCGATTCCCGAACATCCGGAAAGGCGC
+CGGATGTCCGTCTATCTCCTTAAAACCGTATTTTTCCATGCGCTCCGCGCAAAATTGCGC
+CTGGACATGTCCGGGACTCAATTTGAAACCGTATTACCGCTGTTTCAGCGCCGCGTCCCG
+GTAAAAGCGCTCCAGCCCCAGCGCAATGGCCTGCGCCAGTCGCTCGCGGCCCGTGTCGCT
+CATCAGGGTGCGGAGGTTGCTCTTGTCGGTCAGGAAGGCCGTCTCGATCAGGATGGAAAG
+CTGCGTGGTGGGCCGGGTCAGCGCGAGGTTCTGGTAATGCACGCCGTCGTTGCCCACGTC
+GGGCAGTTTTTCCACCAGGGCACCCTGCACCGCGTCGGCCAGGGCGCGGGCCTGTGGATT
+GTAAAAGTACACGCCGCTGCCGCGCTTGGTCCGGGGGTCCACGCCGTCAGGCAGCGCGTT
+GGCGTGGATGCTGACGAGCAGCTCGGCGTTCTTCGCCTCGGCGAGCAGTGGGCGGTTGTA
+GATAGGCACGGTGGTGTCGGCCTCACGGGTCAGAATCACGTTGGCGCCCTTCTCGCGCAG
+CAACTCGGCAAGGCGTAGCGTCAGCGGCAGCGTGAGGTTCTTCTCCGGCACCCGCAGCGG
+TCCCGCTCCGCCGAACTCGTCGCCGCCGTGACCGGGGTCGAGGACGATGGTGCGTCCGGC
+AAGCGGCTGGCGGGCGTTGATGGCCGGAGCATTCCGCACCCGCAGGGTCAGGGTGTTGCG
+CTCGGCGGAGTCGTCGGCGCCGTAGGTCGCGTCGTAGCCCCAGGGCGCCCCGTTCAGGTC
+CACGTGCAGGCGGACCACGCCGTCGGCGTCCTGCACCCAGCGCACGTCGCGCACCGCGCC
+CGTCGGGACGTCGGAGACGATGTACTCCACGTCGGACACCGCGTGGAACAGCCGCAGGTC
+GAGGCTGCCGCCCTGTCCGGCCTGCTGCTCGACGGTAAAGGGCACGCGCTCGGGGAGCAG
+CACCTGCACTTCGCTGTGGGTGCCGCTGTTTTTCACATTGATGTTGGCGAACACGGCGCG
+GGGAAGGGGCGTGCCTTCCGGGCGCAGCGTCAGGGAGCTCTTCGGCGCGTTGAGCGTCAG
+GCCATCCGACACCTGCACGGTGTAGGTGCCCCCTTCCTCGCCCACCACGATGGTCCGGGC
+GCCGGGGCGGGGGTAGACCACGAAGTTGCGGCCCGCGCCGTTGCGCCACACCTGCCCGGC
+GGCTTGCAGGCCGCGCCCAGCGACGGTGGCGGTGACCTCGGCCACGCGGGGGCCGGTGCC
+AGTCACGCTGAGTTTGCCGGTGCTCTCGGCGGTGGCCGTGGTGCCGTCCGCGCCGGTCAG
+CGTGAAGGACACGGGCGCAGCGGCGAGTTGGGCGGGCAGCAGGAAGGTGCCCTCGTACTC
+GCCGGGCGACGTTTCAGCCAGGGGAAAGGGGCCGAGGTCGCCGACCTTGTAGCTCGCCTT
+CCCACCGGGCGTGCCGCTGAAGCCGACCGGCACGCCGCGCGTTTCCAGGTTCGCCGGTTG
+CAGGTAGGCCACCCGGTTCTCGTCGGGCAGCACGCTGTCGGCCACGATTTGTGCCGCGCC
+CCTCAGGACTGTCTGCGGGCGGCTGGTCACGCGCAGTTCTTTGGTGCTGGTCACGCCGCC
+GAGGGTGGTTTCGAGCTTCAGCACATTCTCGCCGGGGGTCAGCGGCACCCACTCGATAAA
+CAGGCCGTCGGCGCCCACGTCCACCGGCTGTCCGCCGAGGCTGAAGGTCGCGCCGGGCTT
+GACGCTGCCTTCGAGCAGCACGTGGTCGAAACCCACGCTGTACTTGTCGGGCGGGTACGC
+CACAAAAATCGGCTCGTCGCTGATAGGCGGCAGCAGTCGGGTCGCGCTGGCGGGCGCCGG
+CGTAGGCGAGGGAGCTGCGGGCGCGGCGGTTTGCGCGGCAGCGAACGAGGCGAGCAGCAG
+GGCGGGGAGCAGGGTACGTTTCAAGATAAAGACCTCCCTCGAATTGTGGTTCGGGGCGCA
+GTGTACGTCAGTTGCCCGACTTGAGGCCAGCGCGTCTGAGTTCGTTTCTGAGTTCCGCCA
+CCGAGTAGCGGCGCGAAGGCAGCCGCAGCAGCGTGAGGCCCCCGGAGCGGAAAATCACGT
+CCTTGACCGAGTCGCGGTACTGCTGCTCGGCTTTCTGGTGCGACTTGCCGTCGAGCTCGA
+TGGCCAGCCGGGGCCGGAAGTGGTCGGCGGCGTCCACGATGATGAAATCCACGTGCTTGT
+CGCGCAGCCGCCCCAGCACCGCGCCGCGCTGGGCGGGGTCGTCGATGGTAAAGAGGTCGT
+TGAGCCGCACATTGGGAAAGGCCCGGTAGCTCGTGCCGCGCAGCGCGTCTTCCAGAGCGC
+GAAAAAAAGCGTTCTCGTCGGCGGAAAAGAAGTAGCGCCGCGCCGAGACGGGCAGCGAAG
+TCGGCACCCGTTTTTCGCCGGCCAGAGGAGATGGAGGTGAGGAAGAAGCCGGCGCGGGCG
+CGGCGTCCCGCAGGCCGAACAGTGAGGCGAGGCATCCCAGGGGCATGGGAGCAGTGTAGG
+CAGGCATGGAATCGCGGTGGATTTGGGCCTCTGCATGAGACGCGGGTCAGCGGCGGCTGG
+CCTATGCTATAGGGAGCCGCCAACTCGGTATACTCTCCCGAGTCTTTGTACTGAGTTCAA
+TATTCCGCCTGCCCCGCTGCGCCGCGCCCCTGCGCTTCCCCCGGAGGTTCCCGAGTTGCT
+CCCCCTTGCCCATCAAATCGCCTTTTTCATCTTCGCTCTGGTGACCGGCGCTGTCGGCGC
+TTACGGCTTTTACCGGCTGTTTTTGCGGATTCGCCGGGGCGTCCCTGCCAGCGAGTGGCG
+CTGGAACGACGCCCCGCAGCGCATCGGCTACGCGCTGGTCACCTCGCTGACCCAGGAACG
+CACCTTCCGCAAGCGGCCCTGGATTAGCGTCCTGCACGCCTTTATCTTCTACGGCTTTAC
+CTACTACTTGCTCGTCAACGTCGTGGACGGGCTGGAAGGCTACCTTCCCTTCTTGCACAT
+CAGCAGTGCCACTCCGCTAGGCGCGCTCTACAACGTCCTGGCCGACATCCTGAGCCTCGG
+CGTGCTGATCGGCGTGATCGGGCTGGTCATTCGCCGCCTGTGGGGCAAGAGCCGGCGCGA
+CTTCCGCTTTACCGACAAGACGCTGCTGCATCCCCTCGTCAAAGACAACTACATCAAGCG
+CGACTCGCTGATCGTCTCGGCCTTCATCACCTTCCACGTCGGGAGCCGCATTATCGGCAA
+CGCCGCCAAGATGGTGCAGGAAGCCCGGCTGGACGCGGGGCACTACGACGCCTTCCAGCC
+GTTCTCCTCGGCGGTGGGCAGCGCGCTGTTCGGCGGCCTGAGCGACTCGGCCTTGCAGGG
+CTGGCGCCTCTTCGGCTTCTGGGGGGCGCTGGGCAGCATTCTGCTGTTCCTGAGCTACTT
+CCCCTTCTCCAAGCACATCCACATCTTCATGGCGCCGGTCAACTACGCGCTCAAGCGCCC
+CGTCAACAGCGGCACCCTGCCCCCCATGAAGGGCCTGGAAGAAGCGATGGAGGCCGAGGA
+ACCCAAGCTGGGCGTGGAAAAACTGGAAGACCTGGAATGGCCCCGGTTGCTCGACGCCTA
+CGCCTGTATTCAGTGCAACCGCTGTCAGGACGTGTGCCCGGCGAACGCCACCGGCAAGGC
+CCTCTCGCCCGCCGCGCTGGAAATCAACAAGCGCATGGAACTGAACGTGATCGCGGCGCA
+GCACAACCCCTTCGTGCTCAGGCCCGTGCCGTTCGAAGCCGGCGAAAGCACCGCCCGTCC
+GCTGCTGGAATACGCCATCAACGAGGAATCGGTGTGGGCCTGCACCACCTGCGGCGCCTG
+CATGCAGGTGTGCCCGGTGCAGGACGAGCAGATGCTCGACATCGTGGACATCCGCCGCAA
+CCTGGTGATGGTGCAGGGCGAGTTCCCGCCGCAGCTCCAGACCGCCTTCCGCGGCATGGA
+ACGCGCCAGCAACCCCTGGGGCATCTCGCGCGACAAGCGTATGGAGTGGGCCGAGGGCCT
+GAAAGTCCCCACTATCGACGAAAACCCCGAACCCGACGTGATCTACTGGGTGGGCTGCGC
+CGCGAGCTACGACCCCGGCGCTCAGAAGGTGGCCCGCTCCTTCGTGCAACTGCTCGACAA
+GGCGGGCGTGAACTACGCCGTGCTGGGCAAGAAGGAAGCCTGCACCGGGGACAGCGCCCG
+GCGCGCCGGGAACGAATTCTTGTACCAGCAACTCGCGCAGGAAAACGTGGAAACGCTCAA
+TCAGGTGGCGCCCAAGCTGATCGTGGCGACCTGCCCGCACTGCATGAACGCCATCGGCAA
+CGAGTACCGGCAGATCGGCGGCGACTACCGCACCATTCACCACACCGAATACCTCGAGCA
+ACTCGTGGCGGCGGGCAAGCTGCCGACCGCGCAGCTGCACGACAACGTGGTCTACCACGA
+CCCCTGCTACCTGGGCCGCCACAACGGCGTGTATGAGGCGCCCCGCCAGCTGATTTCGCA
+GATGGCTGGGCAAATTCTGGACATCGAACGCCAGCGCGAGAACTCGTTCTGCTGCGGTGC
+GGGCGGCGCTCAGTTTTGGAAGGAAGAGGAAGAAGGCCGCGAGCGCGTCTCCGACAACCG
+CTTCCGCGAATTGCAGGCGCGGCTCGACACCGCCGCCGAGGCGAGCGCCGAATTTGAACG
+CACCGGCAAGGTGCTGGCGGTGGGCTGCCCCTTCTGCAAATCCATGATGAACTCCACGCC
+CGAGAAGCAAAAGCGCGACGACATCATCGTGAAAGACGTGGCCGAGCTGATGCTCGAAAG
+CGTGCAGCGCGCCAGTGGCGAGTGGGTCGAACCTGCCGTGGCGCCCTCGCCCGAAGTCGA
+AGTGCCCAACGCGGCGCTGCCGATGGAACGCACCGGCGACGCCCCCTCCGCCGACGCCCC
+GCGCGACGACGTGGTGGGCACCACCAGCGCCGACGTGGAAAACGCCCAGCCCGGCAGCCC
+GGTGGCGAACGCCGGCACCCAGCCCGAGGCTCAGGCGGCGGCCCCCAGCCCTGCACCCAG
+CGGCGAAGGCACGCCTGTTCCGGCGGCCCGCAAGTCGTGGAAGCCCAAGGGCGGCGACGA
+CGTGAGCGCGGCGGCTCCGGCGCCCGCCCCTGCCGCCTCCACTGCCGAGGGGGCCGCTCC
+CGCCCGCAAGAGCTGGAAGCCCAAGGCGAGCGCGGATGATGTGGCCTCCACCGCGACGGT
+TATCGAAGCCGCACCCGCAGCTCCGGCCCCCGAAGCTACCGGCACCCGCAAGGCCTGGAA
+CCCCAAAGCGAAGGCCGACGACGTGGGCACCGCGCCCGCCGCGCAGCCTGCCGTTCCTGC
+TCATGCCCCTGCCGCTGAAGGTGCCGCCCCCGCCCGCAAAGCCTGGAATCCGAAGGCGAA
+GCCCGAGGACGCTGCCCCTGTGGCGCCCGCCCCCATGCGCGACGACGTGAACCCGGCGCC
+GGCAGCTCAGGCCACGGCATCTGCCGCCCCCGCCGAAACGGGCGCCACGGGACGCAAGGC
+CTGGAACCCCAAGGCGAAAACTCCGGCAGCGGCGGAAGGGTCGGCCCCGGTTCAGGAAGC
+GGTGCAGGAAGTTGCTCCTCAGCCTGCCGTCGCTCCTGCCCCCGTGCAAGGCGATATTCA
+GGATCCGCTGCCCCAGCCTCCGGTCCAGCAGGCCAGTGCCCCCGCCCAGAGCGGTGAGCG
+CAAGAAGTGGAACCCCAAGGCGAAAGCCGAAGCGGCGCCCGCTCCTGCTGCCCCCGCCGC
+GCCCATCACCGAACACGTCGTGCTCGACGAAGTCGGCGTCAACGGGCTGGAAGAAGGCCC
+CGAGGCGACCTCCGCCCCCGACGCGGCCCCGGTCACGACCCAGCCCGCCACCCCCGAGCC
+CTCTGCCTCCCAGACCGGCGAAGTCAACGCCGAGACGGGCCGCAAGAAGTGGCAGCCCAA
+GAACAAGGGCTGACACCCACTCCTGAGTCGAGTCCACTGAGTGAAGTACGCCCCCGCCGG
+GAAACTGGCGGGGGTTTTGCTTTGCCTGCCCTCTACAATCCGGGCGTGAACCTCCTGCTC
+ATTCGGCACGCGCAGTCCACCAACAACCTGCTCTACGCCCAGACCGGAGGCAGCGAGGGC
+CGCTCCGCCGACCCGCCCCTGACCGAACTCGGCCACGCGCAGGCACGGGCGCTCGCCGAG
+TTCGCCCGCACCGACGAGACCCTGCGCGGCCTGACCCACCTGTATTGCAGCCTGACCACC
+CGCGCGGTGCAGACGGCGGCGCCACTCGCGGCGGTGCTGGGGCTCGGCGTGCAGGGCCTC
+ACGCACGCTCACGAGACCCAGGGCCTCTTCCTGCGCGACGAGGCCGGGGTGCCCCGGCCG
+GTGCCGGGCCGCACCCACGCCGAGCTGCTGACTGAGAATCCCGCGCTGCTCTGGCCCGCC
+GACCTCGCAGCGGAGGCGGCCTGGGAAGGCGGTTTCGAGCCCGAGGACCACGCGGCTTAT
+CTGGCCCGCGCGGCCCGCGTGGTGGGTGAACTGCGCGCGGCGCACGGCCCTCAGGACACG
+GTGGGGCTCGTCACCCACGGCCACTTCACCCAGTTTCTGCTGCGCGAGCTCATCAGCCAC
+GGCACGGCGTTTTTCCGCGTCGCCAACACCTCGACCACCCTGCTCACCCTGCCCGGCCCG
+CAGGACCCGCCCGAGTTCGGCCCGCTGGTGGGCTGGGTCAACCGGCACGACCACCTGACG
+CCGGAGCAGGTCACCGTTTGACCGGAGCTGTAGTTTTGCTTACAGAGACGCACTTTTGCG
+GCCCTTCCCGTTAGAAATACTAAGGACGGCTGCCATCCGGTCAGGGTTTCTGCGGGTCAT
+GCTGAGGCACTGCCACTTCGGAACCCGAGGTGGACAAAGGAGCACCCCATGAAACTGAAG
+ATGTCCGACCTGATGATTCTGCTGGGCTACGCCTCCATCGGCTATAGCGCCTACCGTTAC
+TTCACTGCCAGCGACGACGACTCCAAGCGCGACGCCCTGTTCGTCGGTCAGTGGGCGCCC
+ACCTTCTTCATCCTGGGTGTGGGGGCCGAAAACCGTGAGTACCGCAAGCAGAATACCCTG
+GCCCTCGACGCCAACGCCTGAGCCCCGAACCTCTCCGCAGAGGCCGTCCATCCGGGCGGC
+TTTTTGCTTTTGCGGCCCTCCGCCCCTTTTCGATGTCAAGGTGACTTATGAACCTGACTC
+CCGCTCAACGCAGCAATTTCTTTCCCCTGACCGCCTGGGGGTATCCCCTGTGGCGCGCCC
+GTTCGCTGACGTGGCTGGCCGGAGAACCGTTCGGGCTGGCGCGGGAAGCGCGGCTGTTTC
+TCGGGCTGTGCCGCCCTCATGCTGGGGAACGCTGGCTGGACGTGGGCACCAGCACCGGGT
+TTTACGCCGGGGTGCTGGCGCGGGCGGGCTGCCGGGTGGTGGCCGCTGACCTCAGCCCCG
+CCATGCTGCACGCGGCGGCGCGGCGGGAACCCCGGCCCCAGATCGAGTGGGTGCAGACGA
+ACGTGGAAGAGACCGGCTGGCGCACGGCGAGCTTCGACGGCGTGGTCGTTGGGGCGACGT
+TGAACGAAACCGCCGACCCCGCGCGGCTGCTCGGCGAGTGCGCGCGGCTGCTGCGTCCCG
+GTGGCAAGCTGTGGCTGATGTTCGTGCCGCGCACGGGCGGGCCGCTGCAAGGGCTCCTCG
+CCCGGCTCGGTGGGCTGACCTTTCCTGACCTGAGCGCGGTGGAGACTGCCTTGCCCGGCG
+GCGCCATCGTTCACGCCCGGCGGGCGGGGGCCGTGCAGTTCGCTCTGTTCGTCCGGGGCA
+ACGGGTAGGCTGGCAACATGCCGCCCCTCCGCTCCCAGATTCGGCCCGGCCTGACCGTGG
+ACATCGTGCAAAAGCAGGACCAGCCCACCGGCAAGCTGACCCGTGGCGTGGTCGCGGCGC
+TGCTCACGCGCTCGCCCTCGCACCCGCACGGCATCAAGGTCCGGCTGACGAGCGGGCAGG
+TGGGCCGGGTGCAGGCGGTGGTCGGCGGGGAATAAAGAAAGTCCGACTTTCTGGCGCGGG
+GCCGCGAGGCTTACGTTAACGCCGGAGGTGCGCCATGCCCAAAGCCTGGAGCAACAAAGA
+CGAACGTCAGTACGAGCACGTCAAGGACAGTGAGGTCAAGCGCGGCGAGTCGCCAGACCG
+CGCCGAGGAAATCGCCGCCCGCACCGTCAACAAATCCCGCCGCGAAGAGGGCCGCACCCC
+GAACAAGCGCACCCAGGGCACCGGCAACCCGGACGCCGCGCTGAGCGACCTGACCCGCGA
+CGAGCTCTACAACCGCGCCAAGGAAAAAGGCATCGCGGGCCGCAGCCGCATGAGCAAGGC
+GGAACTGGTCAGGGCGCTGAGCTGACCCCCGCTGCACCATAAAAAAGCCCCTCCCAGCCG
+GAGGGGTTTTCTATTTGGCCGGTGGCTCAGCGCTTGGGCATGCTCAGGCCGAGGCCGGTG
+AGAAAGCCGCCCGCGACGGCGAGCGCGGTCATGAGCATGACGTTGTTGACGGGGTTGGGG
+CCCTCGTTGCTCTTGTTGGCGTAGGCGATGGCGTGCAGCTGGTTGATGTCGATGTAGTTC
+TTCGCGAGATAGAACAGGCTGGCCACGATGACCACCAGGCCGATCAGCACCACCACCTTG
+GAGAGAATCTGCATGGTTCAAATTGTAAGTCTCCGCCCGTTTGTGCCTCTTGGCCGTTCG
+GAAAGATTGTGGCGGGGCAGGGTCATCAGGGTCAGTGGGTCAGCGTCCGTGCGGCGTCGC
+GTCCAGCCAGGCGGTCAGCGCCTGAGCCACGCCCGCCGGGTCGGTGACGACCACCGGCAC
+GCCGAGCGAGGCTGCCGCGCTCGCTGCCGCGCACTCGCCCTGTTCCCCCATTACGGTCCC
+GGCGCCGGTCCAGGCGGGAAACGGGCCGCCTTCCTGGTAGGGCGCGCCGCTGAGGTCGTC
+CACCACCCGCGCGGGCACCTCCACCGCTGGGCCACCTGCGAGGGCCCGCTCGGCCACCAC
+CAGCACGCCCCGGTGTTCGCCTTCTTCCAGCGCGCCGAGCAGCGGGGTCAGTCCGTCGTG
+GACGAGCAGCTCGAAGGTGCCCTTGCCGTCCACTGCCGCGAGGGCGGCGGGCAGCGCAGC
+GGCGAGTTCGGGCGGCGCGGCGACCAGCCAGCGGTGGCCCCCGGCGCGGCCCTCGAAGCT
+GGCGCGGGGCGAGCCGTACACGTCCGTCCAGGTGCGGGTGTGTTGCATGGCGTCATCATC
+GGGCATGGGGGCCAGAGGGGCAAGCGGAGTCGCCCCGCTATGCTGCGCTCATGACGCTGC
+CTGCTCCCCGCACCCACGGTTCCGTTCGTCTGTGGTCGCTCCCCACCGGCCCCCTTCAGG
+AAAACGCGCTGCTCGTGGCGGGCTCGGACAACCAGGGCTTCTTGATTGACCCCGGCGACG
+AAGCGGCGCGCATTCTGGACCTCGTGCGCGCGGCGGGGGTGGACGTGCAGGCGATTTTGC
+TCACCCACGCGCACTTCGACCACATCGGCGCGGTGCAGCCGGTGCGCGAGGCGCTCGGCG
+TGCCGGTTCACCTCCACGCGGACGACCTCGCCACCTATCACCTCGGCGCGGCGTCGGCGG
+GGCGCTGGAACCTGCCCTTCGTGCAGCCCGCCGACCCCGACCAGCAGATTGCCCAGGACC
+AGACCTTCACGGCAGGCGACCTCACCCTGACCGCCCGTGAGCTGCCGGGGCACGCGCCGG
+GGCATGTGGTGTTCGTGGGCGACGGCTTCGTGATTGCGGGCGACACCCTCTTTGCCGGGG
+GCATCGGGCGCACCGACCTGCCGGGCGGCAACCACCCGCAGCTCATCGCGGGCATCGAGC
+GCGAACTGCTGAGCCTGCCGGACGACACCTACGTCTACCCCGGCCACGGCGGCTTCACGA
+CGATTGGACGGGAGAAGCGGAGCAATCCGTTCCTGTAGAGCCTTTGACAAAAAGATGGCA
+CAGCTTTTTGGCGAGCGGAGCGAGTGCAAAACACGGAGCAGAACGGACTTGCAAAGCTGC
+GAAGCAGAGAATGGAGCGGGTGGCGGTGCTGTTCCGACGCACGCGTCATTCGGAGAACTG
+CTCTAAGGCAGGAAAAAAGGCGCCAAGGTGAGTTGACCTTGGCGCCGTTTCTTTTTTCTC
+TTCCCTCAGTCGAAATCCATCGCCCACCACGCCTCGCGCTGTTCGGCCATGCGGGCGCGG
+GGGTCGCCGAGGGTGTCGAGCGACGCTTGCAGGCCCTTCCAGTCCTGTTCGCTGAGGGGG
+TCGAGCGTGAGCGCGCGCTGGTGGTATTGCGCGGCCTCCTTGGGCTTGCCGGCCAGGCTC
+GCGGCGCGGGCGGCGAGGCCGAGCAGGTTCATCTGGGTCTGTTCGAGCCGCGAGCGCACG
+TCGTCCACCCAGGGGCTGTCGGCGCCGGGCAGGAACGTGCCGTACTGCCCGACGAGTTCC
+TTGAGCTCCTCGTAGCCCAGACTGCCCGCTTCGGCCTGTCCGGCGAGCAGTTCGTAGCGT
+TGCACGTCGTACTCGGGGTTCAGGCCAGCGGCGAGCGCGTACTTGCGGTTCTGGCTGGTC
+ACGGCCTCGTTGTTCAGGCTCTTGCGCAGGCGGTGCAGCGTGGTGTGAAAGAGGCTGCTC
+GCCCGCGACTCGTCTTTTTCGGGCCACAGCGCCTCGGCGGCTTCCCAGCTGGTGACTTCC
+TTGTGTTCGAGCAGGTAGAAAAACAGTTCGAGCGCCTTGCGCGACACCCACGACACCTGC
+TGCCCCTGCCACAGCACCTGCGCGGTGCCGAGCCCCTTGGCCTGGGTGCCGCTTTCGGCC
+TGCGCGGTCAGGCCCACCCGGCGCAACCGGGCGTCCACAGCGGTGGTCAGGCCCTGCGGC
+GTAAAGGGCTTGGGCAGGTAGTCGTCGGCGCCGAGGTTCATGCCCCGGCGCACATCGGTC
+CGCTCGGCGTGGCTCGAGAGCAAGATGAACGGCATCGCCGAAAGGTTCTCGTGGTCGCGC
+ACCTGTTCCAGAAATTCCAGGCCAGTCATGTACGGCATCACCACGTCGCTGATGATCAGG
+TCAGGGGTAAACACTTTGAGCAGGTCCAGCGCTTCCACCGGATGCGAACAGCTCCGCACC
+TCGTGCCCGGCGCGGCTGAGAATGACGCTGATGAGCTTGACAATGGCGGCGTCGTCGTCC
+ACGACCAGAATGCGCGGCATATGAGAAGTCTAACAGTTCGTCTCCGCCGCCGGCCGCCCC
+CACCCTGACGAATAAGGGCCCCCCTTACAATCTCGTGAGAAGCGGCCTGAAGTCGGTTTG
+TGCGGGCGTGTGTCCTGTTGTCCTGTTTGCCCCGCTGCCGCTGTCTGCCCGCCCTCCAGA
+TGCGCAGCGGTCAGGGCGCTATCCTTTTTCCCATGACGTATCAGGCGGTCATCGGGCTCG
+AAGTGCACCTGCAACTGAACACCCGGTCCAAAATCTTCAGCGCCTGCCCCGCCGACTACC
+ACGGCGCGGGGCCGAACGAATTCACCGACCCCTTGACCCTGGGCCTGCCGGGCACGCTGC
+CCACCCTCAACCGCCGGGCGGTGGAACTCGCCATGATGTTCGGTCTGGGGCTGGGCTGCG
+ACGTGTCGGGTTTTACGCAGTTTCACCGCAAGAACTACTTTTACCCCGACGCCCCCAAGA
+ACTTTCAGCTCTCGCAGTACGATCGCCCGATTGCGCGTGACGGGTATCTGGACGTGCCGG
+GAGAGGGCGGCCCCGAGCGCATCCGCATCAAGCGGGCGCACCTTGAAGACGACGCGGGCA
+AGCTCGTGCACCCGACCTACGCGCCCTACTCGCTGCTCGACCTCAACCGGGCGGGCTCGG
+CGCTGATTGAAATGGTCACGGAAGCCGACATCACCGGCCCCGAGCAGGCCCGCGCCTTTC
+TGGAAAGCGTGCAGGCCATTGCGCAGTCGCTCGGCGTGTCCGACGCGACCCCGGAGGAAG
+GCAAGATGCGCTGCGACGTGAATATTTCCATTCACAAGCCCGGCGAGCCTTGGGGCACCA
+AGGTGGAAGTCAAGAACCTCAACTCCTTTCGCTCGGTGGCCCGCGCCATCGAGTACGAGG
+CCGCGCGGCAGGCGAAGGTGCTGGACGCGGGCGGCATCATCACCCAGGACACGCTCGGCT
+GGGACGAGGGCGGCCAGAAGACCTTCCTGATGCGGACCAAGGAAGGCGAGGCCGACTACC
+GCTACTTCCCCGAGCCCGACCTGCCGCCGCTCGACATCACCCCCGAGTGGATTGCCGAGG
+TGCGCGCCCGGATGCCCGAACTGCCCGCGCAAAAGCTGGAGCGTTACCGGGCAGCGGGCG
+TACGCGAGAGCGACGCGCAGACCCTGAGCCTGAGCGTCAGCCTTTCGAAGTTCTACGACG
+AGGCTCTCAAAAGCGGCTCCGACACCCAGAAACCGGATGCCCAGAAGCTCGCCAACTGGC
+TGCTCACCGACGTGGCCGGGGCACTCGCCGCGCAGGAAAAGGGAGTTGAGGACAGCGACC
+TCCAGCCCGCACACCTCGCTGCGCTGGTCGGCCTGATTGACGCCGGAACCATCAGTGGCA
+AGATTGCCAAAGACCTGCTGCCCGACGTGCTGGCGGGCCACGACCCCGCGCAGCTGGTGC
+AGGAGCGCGGGCTGAGCGTGGTGACTGACACCGGGGCGATTGACGCCGCCATTGACGCCG
+CGATGGAGGCCGACCCCGCGACTGTAGAGAAGGTGCGCGGTGGCAACGCCAAGGCGATGA
+ACGCGCTGTTCGGCCCAGTCATGAAGGCGATGGGCGGCAAGGCCAAACCCGAAGTCGTCC
+GCGAGCGCCTGACCGCCAAGCTGGGCCTGTGACCGCGCCGGCAGGGGCTTCCGGCAACCG
+CTGGCGCCTCCCGGCTCTCACCGCGCAGTGGCTCTACGTGGCCGCCAGCTTGGGGCTGAC
+CGCGTATACGCTGCTGCCGGGGCTGAATGAAGGCACGGTCGTCACCGGCCTGCGCTCGCT
+GCTCGCCGCGCTGGTGGGGGCGTGGTGGGCGGTCATTTTCGGGCGTTATCTGCTCGGCCA
+GGGCACGCCGGACACCGACGGCACGCTCAGGGCGCTGCGGATTTTCTTTCCCTGGCTCAC
+GGCGCTGCGGCTGTCTTTGTGGCTCATCGGGCTGCTGGCGCTGAGCGGCAACGTGACGGC
+GGAGGTCAACCCGGTGGCGCTGACGGCGCTGCAAACCCTGTCGTTCGGGTACATCTTCGC
+CAAGAACGCGGTGTACGGCACGCTCGCCCGCTACGCGACCGACCCGGCGAACGCGCTGGG
+GCGCCGGCGCCTGGGCGAGTGGCTCAACGTGGCCGCGCCGCTCGCCCTTGCCATCGGGGT
+CATCAACACCGTGCCGCTGGGCGGCGTGAGCGAGGGCTTCCGGACGCAGGACGTGGTGAT
+GTATGGCGTCCACGCCGCGCTGGACCTGCTCGCGCTGGGGCTGAGCCTGCTCGCACTGCG
+CGAGATGCAGACCCCGGTGCGGGAGCGGGAGGCCTGAGCTGGGCCGAGTGCGGCAGCCCC
+CTTACTCTCCTGGCCCCTTGCTATCCTGAGCCTTACGCATGACAGACGCCTCTTTTCCGG
+CCTTGCCGCCGCCGCTGGTGTCCCTGGGTGACCTCGCCTGGGACGTACTGGCCAAACCCG
+ACACCCTGCTGCTGCCGGGCGGCGACACCACCGGGCGCCTGGAACTCTCCGGCGGGGGCA
+GCGCCGCCAACCTGGCCGTGTGGGCCGCGCGGCTCGGCGCCCCGACCACCTTCGTCGGCA
+AAATCGGCCAGGACCGCTTCGGCGAACTGGCGACCGCCGAACTGCGCGCCGAGGGGGTGC
+GCGCCGAGGTGCTGGCAAGCGCCGCGCACCCCACCGGCGTCATCCTCGCCCTGATTGACC
+GCCGGGGCCAGCGCGCCATGCTGACCGGGCAGGGCGCCGACTGGGAACTGCTGCCGGAGG
+AGCTGCCACGCGACGTGCTCTCCAGTGCCGGACACCTGCACCTGACCGCCTGGAGCCTGT
+TTCGTGACCCGCCCCGCGCCGCCGCGCTCGAAGCGGCCCGCATCGCCAAGGCGGGGGGCG
+CCACCCTCAGCTTGGACCCCGGCAGCTTTCAGATGATTCAGCAACTTGGGCGCGAAGCCT
+TCCTGAACATCGTGGACGCGCTGCCCTTCGACGTGATGTTTCCCAACGACGACGAGGCCC
+GCGCCATGAGCGGCGAGCGCGACAACGAAGCGGCGCTCACCTGGCTGCGGGCCCGCTACC
+CCCGCGCCCTGATTGCCCTGAAGATGGACGAGGACGGTGCCCTGATCGAAGGCCCGCAGA
+CCGCCCGCGTGCAGGTGCCCGCCACCCGCGACCCGCTGGTGGACGCCACCGGGGCCGGGG
+ACGCCTTCGGGGGCGCTTTCCTGTCGCAGTGGCTGCGGCACCACGACGCCGAGCGCGCCG
+CCCGCGTCGCCGTGCAGGTGGGCGGCTGGGTGGTCTCGCGCTTCGGGGCTCGCCCGCCCG
+CTGACCCTGACCTCACCCGGCGGCTGGCGAGCGTGGGCGCCGATCTGTTGACCCCTGACC
+CCGCAGCTGCCCCTGACCCTTCCCAAGACTCTCCTGAGGTAAACGCATGACGACCCTGAA
+TTCCCGCCGTGGCCTGCCGCTCTGGGCCAAACTGCTGCTCGGCTTGATCGTGCTGGGCCT
+GCTGGCCGTGCTCGGCGCCTTTGCCTATTTCCGCAGCCTCTTCGGCCCGGCGGGCGGCGC
+CCCCTACACGCTGGAAGTCACGCCCGGCGAGACCGTGCCGCAAATCGCCCGCGAACTCGA
+AAACAAGAAGATCGTCAAAAACGCCCGCATCCTGCGCTACGCCATGCAGCAAAGCGGCGC
+GGCGGCGCGGCTCAAGGAAGGCGCCTACGACCTCAACGGTCAGATGACGGTGGATGAGGT
+CGTCAAGACGCTGGACGGCCCCGCCCGCGTTCCGGTGGTCAACGTGACCGTGCCCGAGGG
+CCGGCGCATCAAGGACCTGCCCGAGATTTTCCAGAAGGCGGGCTTCGACGCGGCGGCCAT
+CACGGCGGCGCTCAACGACGCGTCGCTCAGCCGCTACGCCCGGGGCAAGCAGAAGAACCT
+CGAAGGCTTCGTGTTTCCCGCCACCTACGAGTTCCGCCCCAAGGACAGCGCCACTGACGT
+GGTGAAGAAGATGGTGGAGCGCATGGAAACCGAGTTCACGCCGGGCAACGTCGCCAAGGC
+GAAGGCGCTCGGCCTCGACGTGCGCGACTGGGTGACGCTGGCGAGCATGGTGCAGGCCGA
+GGCCGCCAACAACGAAGAGATGCCGGTCATTGCCGGGGTCTTCCTCAACCGCCTGCGCGA
+CGGCATTCCGCTCGGCAGCGACCCCACCGTGGCCTATGGGCTGGGCAAGGACCTGCCGGA
+ACTCGACCGCTCGGCGGGGGACTTCAAGGTGGATACGCCTTATTCCACCTACACCCGCCA
+GGGGTTGCCCGCTGGCCCCATCAACAACCCCGGCGAGGCCGCGCTCCTGAGCATCGTCAA
+CCCGCAGCGCAAAATGGCGGATGGGCGCGACGCCCTGTACTTCCTGCACGCGGGCGGCAA
+AATCTACGTGAACCACACGTATGCGGAGCACCTGCGCGACAACGACCGCTACCGCTGAGC
+CGACAAAAGGGAGGGGGTGGAGTGCCCGGGACACCGTTCCCGCCGCGCTCCACCCCTTCG
+CTGCCCTTCTCTTTCAGCCCGTTACTTCTGCGCTTTGAGCCACGTCGTCAGGTCGTTGAG
+CGGCTGGGCGTCCATCCAGCCCAGAGTCGGCCTGCCGTCTTTGAGCGGCGAGAGCGAGTG
+CCCCAGGCCCGGATAGACGATGAGCTTCACGCGCTTGTTGCCCGCTTTTTCGGCGGCGGC
+CTGCGCCAATTTCGCGCCGGGGAGGATGGTCTGCGGATCGGCGGCGCCGTGCAGCATCAG
+CACCGGGCCGCCGTAGCCGGGCAGGTTCTGCGTGACCGAGCCGTAGGCATCGGCATCCTT
+GAAGTAGCGGGCGGCAGCGGGGCCGAAATCCGGCAGGTTGGGGTACGGGGCAAACGCCGC
+CTCCAGCCGGTCCTTGATGGGGCCGTCAATCCGGACGCGGCCCCCGGCGTCGGCCTTCAT
+CTCGGGAAGAAAGGTCCACGTCTTGTCCTTTTGCACCACGCCGAAGGCGGACGCTTGATC
+GGCGAGGTCGAGCCCGAAGCGCTCGAAGCCGGCGGTCAGCTCGGCAATCGTCAGGAAGCC
+GTCGTGGTCGGCGTCCATCAGCTCGTGAACCTGCGCGAGGGGCCGGTCGACGAGCTGGAA
+ATGCAGCGTTTCGCGGAAGGTGTAGCCCACCGTGCCGATGAGCACCAGCCCGCGCACCAG
+CTCCGGGTGCTCGCGGGCGATGCGGGCGGCGAGCATGGTGCCTTCCGAATGACCGAGCAA
+AAAGACCTCACCGGGGTTGACCTCGGGCAAAGTCCGCACGGTCTGGAGCACGCCCAGCGC
+GTCGGCGGAAAACTGCGAGACGGTGGCCTGTTCGGGGCGGGCCGCCGGGTCGATGCGGGG
+GCCAGCGCCCAGCACGCCGCGCTTGTTGTAGCGCACCACCGCGAAGCCCGCCTCGTTGAG
+CTGCCGGGCGAGTTGCAAAAAGACCTTGCTGCCGCCGGGCACGCCGCTCACCTGTTCGGG
+CAGCGTTTCGTTGAGGTCGTTGGGGCCGCTCCCGTGCAGCAGAATTACGGTGCGGAACTT
+CTGACCCGGCTTGGCCCCCGGCGGGAGGCTGAGTTCGCCGGTCAGCGCATAGCCGTCCGC
+GAGCTTGAAGGTCAGCGGGCGAGTGTTTTGCAGAACGATCTGCGCGGGTGGGGCCGGAGG
+TGGGGTGGTCATGCCCAGAGTGTCGGGCTAGGCTACTTGCCATGCCAGAGCAAAATGCAA
+GTAGCGTACTCGTCCAGTCCGAGGGCGCGGCGCTGGCGCTGCTGGGCGGCATCGTGAGCG
+GCGAACTGGGGCCTTTTCGCCAGGGGCCGCTGAGTCCCGCGCAGTGGGCCGCGCAGCGAG
+GGGAACCGCTCTACCGCACGCTGCGCCGGGTGCGCCGCTGGCAGGCGCTCGGCGTGCTGG
+ACGTGCAGGACACCAAAAAAAGGGCGGGGCGGCCCGTGCGGCTCTATGGCCTGACCTCCC
+CCTCCTTCTACATTCCGCACGCCGTGTTGCCCGTTGACGAGGTGCTGGCGCGCATCGGTG
+AGCCGATGGAACGCCAACTGCGCGCCGACATCGCTCGGGCCTTTGCCGACCTGCCCGACA
+TCGGCGGCACCCAGATCGTGATTCACGGCGAGACCTACGGCGCGTTTCTCGCTCACTCGC
+CCGGTCAGCCCTGGGGCGGCAAAGACGACCTGGTGCTGATTGACCGCTGGGCGAACCTGC
+GCCTGACCCACGCCGACGCCCTCGCCTTTCAACACGAACTCGACGAGCTGTTTGCCCGCT
+ACGAGCACCGGTCGGGGCCACAAAGCTACTCGTTGCATCTGCGGCTGGTGGCCTCGGCGG
+GGGGGGGGGCGAGCCGTTAGAGAGGCACGAGCCGCGTGGAAGCAAACAAAATGCGCTGCG
+GCTATTCCAGAAATGCCAGTAGCTCTTGATTCACCCGCAGCGTTTCGTCACGCATGACCC
+AGTGGGTGGCGTGGGGAAACTTGACGGTTTTCAGGTTGGGCACCCACTTGCCGAGGTTGT
+CGGCGAGCTCGGGCACCAGAGCCGAATCCTTTTCGCCCCACAGCAGCAGGGTGGGGGCGT
+GAACCTGCCGGCCCTTGACGTTCCCGAAGCGGATCAGGGCGCGGTAATAGTTGATCATGG
+CGGTGGCCGCGCCGGGCTGTGTCCAGGCGGTTTCGTAGTGGTGCATGTCCTCGGCGCTGT
+AGCTGCCGGGCCGCGCTCCGCCCAGGCCCTTGCGTCCAAAGGGCACCAGCAGGCGCTCGG
+GCAGCCAGGGGAGCTGGAAAAAGCCCACGTACCACGAGCGCTTTCTCTGCTCGGGACGGC
+GCATTTCCCGTCCGAAGGCGCCGGGGTGCGGGGCGTTGAGAATCACCAGTTTGTCCACCA
+CGGCGGGCCGCGAGATGGCGACCGCCCAGGCAATCACGCCGCCCCAGTCGTGCCCGACGA
+TATGGGCGCGCTCGTGCCCGAGGTCGTGGATGAGCGCCGCCACGTCGGCCACCAGCGTAT
+CGATGTGGTACGACTCCACGCCCTGCGGCTTTTCGCTGATGTTGTAGCCGCGTTGGTCGG
+GCACCACCACCCGGAACCCCGCGCGGGCGAGCGGCCCGATCTGGCGGTCCCAGCCGCGCC
+AGAACTCGGGAAAGCCGTGCAGCAAGATGACCGGGGGGCCCTGTTCGGGGCCGGCCTCCA
+CGCAGTGCAGCCGCACCCCGTTCACGAGGCGTTCGGTGTGCCGAAGTTCGCTTGACATGG
+TCCCAGTATCCTCCCCGGCGTGCGCGGCGCCGTGACCGCTGCCGGTGCCATTGTCTTTAG
+TTCGGCCGCGCTAGAGCATTTGACATAAGAATGTTTCGCATTTTTGACCCTCTACCCTGG
+TAGGACTCGAAGAGCTGCACCAAGGGGTCTTTTTCTGTCAAATGCTCTAGAATGTCCGGC
+GCATTTCGCGTTCCCCCGGACCCTGACGGCCCGGCGCGCCGGACGCACGCTCTACCTTTT
+TTTCGCGCAGGTTCGCACAGCACAGGAGACTTCTGAAACATGGCCGGTCATAGCAAGTGG
+GCGCAGATCAAGCGCAAGAAGGGTGCCAACGACAAGAAACGCAGCGCGATGTATTCCAAG
+CACATCCGCGCCATTCAGGCCGCCGTCCGCTCGGGCGGCAGCGGTGACCCGGCGGGCAAC
+CTCAGCCTGAAAAACGCGATTGCGGCGGCCAAGACCGACACGGTGCCCGCCGACAACATC
+GAAAACGCCATCAAGCGTGCGGTGGGCGCGGGCGAAGGCGCCGCCGAGTACAAGGAGCAG
+ACCTACGAGGGCTACGGCCCCGGCGGCACCGCCATTTTCATCGAGACGCTGACCGACAAC
+GTCAACCGCACCGTGGCCGACATCCGCGCCGTGTTCAACAAGCGCGGCGGCAGCATGGGC
+AACTCTGGCTCGGTGGCGTGGCAGTTCGAGAAAAAGGGCATCATCCTGCTTCGCGATGCC
+TCCGAGGCCGCGCAGGAAGTCGCCATCGAAAACGGCGCCGAGGACATTCAGGAATCCGAC
+GAGGGCCTGGAAATCAGCACCGCGCCGAACGACCTCTACGCCGTGCAGGACGCCCTGAGC
+GCCGCCGGCTACGCCGTGGAAAGCGGCCAGATCACCATGCTGCCGACCAACACGGTGGCG
+GTGGCTGGCGACGACGCCCGCAAACTGCTGACGCTGGTGGAATACCTCGAAGAACTCGAC
+GACGTGCAGAACGTGTACACCAACGCCGATCTGCCCGAGGACGAAGAGGACTGACCGAAA
+CGAGAAAGAACAAAAAAGCGGAGGCGTAGGCTTCCGCTTTTTGCTTTGGGTGGGGATGCG
+TTTTCCTGAGCCGTCGCTTCAATCACACGCCAAGGCCAGCTCCGCTTGCCGGGCGAGCTG
+CGTCTCACGGGTCAGATACCAGCGGCTGAGGTCCGAGCCGAGTTCGCGGATGATCGCTTC
+GGCCTGCGGGAGCGCGGCGCGGCGGCTCTGCATATTGCGCTGCACGACGGCGGTCAGGTC
+GTCGAGGTTGTAGAGGTGCGCGCCGGGCACGCTGGCAATCTCGGGGTCAAGGATGCGCGG
+CACGCTGATGTCAATCAGGAACATGGCGCGGCCCGGACGCCCGGCGAGCGCCTCGCGCAC
+GTTCTGGGCGGTGACCACGTAGTGCGGCGCGGCGCTCGATGCGATGACCACGTCGACTTC
+GGGGAGCGCGGCGGACAGTTCCTCGGCGGGGCAGGCGCGGCCCCCCAGTTTTTCGGCGAG
+GGCGCGGGCCCGCTCGGCGGTGCGGTTGACCACCAGCACGTCCTGCACGCCTGCCGCCCG
+CAGGTGGGTCAGAGTCAGCTCGGCGGTTTCGCCCGCCCCCAGAATCAGGGCGCGGCGCTG
+CGAGAGCTCACCGAGCGCGGCCTGCGCGAGTTCCACGGCGGCGCTCGACACGCTGACCAC
+CTTGTCGCTCAGGCCGGTGTGCGAGCGCACCCGCTTGCCCGCCGCCAGTGCGCCCTGCAC
+CACTTTGTTCATCAGGGTGCCGCTCAGACCGCGCTCGCGGGCACTTTGCCAGGCACGTTT
+GACCTGTCCCTGAATCTGGGTTTCGCCGATGACGAGGCTGTCGAGCCCCGCCGTCACGCG
+GTAGAGGTGCCGCACGGCGGCCTCGCCCCGGTACACGTAGAGGTGATCGAGCAGCGCGTG
+GCCCCAGGCGCCCTCGAAGGCGGCGAGCGGGTCGCCGTGCACCCCGGCGAGATAGACCTC
+GGTGCGGTTGCAGGTGGCGAGCAGCAGCACCTCGTCGGCGTGGCGCGCGAGGTGGCCGAG
+CAGCGCGCCTTCTTCCTCGGGCCGCACGGCGACGCGCTCGCGGACCTCGACTGGCGCGGT
+CTGGTGATTGAGGCCGACCACCACAAAATCGAGCGGTGCGGGCTGCGGCACCGTACGCCG
+GGCGAGCAGGTGCTGGGCAGTCGGACACGCGAGCGTCATGCCTGCGCCTCTGGCCGGGCC
+GTCCGCAGACCGCGCGGCGTGAGGGAAGCAGAGAACAGGAGCATGTTGGGCAGCATAGTC
+TTCCGGCGCGGGGCGCGCGTCCCGTACCGAACGGTAAGAAAGCTGTCTGGGTCGCCTTTT
+TTCGTTTCCGGGATTCCTGGGATGCGGGCCCCTGACATGACGACACGTCCTTCTGACGCT
+ACCCTGCAACCGACCTATGACTGCTCCTCCCGCCTTGCAAGACGTGTATGGCGTGCCCAT
+TCCACCCGGCAGGCCGCTGGCCCAGGGCCGGCACGCCGACCTGCTGACCCTCGGCGAGGT
+GCGCGGGCAGGTAGCGAAGGTCTACCTGGCGCCGCCGCCGCCCGCCCAGGCCCAGAAGGT
+CGAGGAACTGGTCAAGGTGCCGCCCCACCCGGACGTGGCCCGGCGCCTGGTGTGGCCGCT
+GGCCGCGCTCTACGGCCCCAACCGGCAACTCGCGGGGCTGCTCTTGCCCCTGCTGCCGCC
+CCAGCAGTTTCAGGGGGTGCGGGCGCTGCTGCGGGCCGACACGCGCCGCCGCAGTTTTCC
+GGAGGCCGACTGGCCCTTCGCCGTGCGGGTCGGGCGCGAACTGGCGCTCGCCTTTGCCGA
+ACTGCACGCCGCCGGGCACCACATGGGCGACGTGCGGCCCGAGCACGCGCTGGTGTCCGA
+CGCGGGCGAGGTGCGGCTGGTTGGGGCCGACGACTACGCGCTGCACCTCGCTGGGCGCGA
+CTTTGCCGGGCCGGTGGCGAGCGCGGAATATCTGCCCCCCGAGCGTCAGCGCGTTGGGAG
+CGCCACTGGCGCTGGGGCCGACGCCGAGAGCGACGCCTTCGGGCTGGCCGTCCTGCTGTT
+CGAGCTGCTGCTGGGCCGCCACCCCTACGCCGGGATTCAGGCACGCGGGGCGGCGCCGGG
+GCCGGGCGGGGCGATTGCCGCCGGGCTCTTTGTGGACGCGCCGCAGGCCGGGCCAGGGCG
+GCGGACCGCGCCGGGCGAGTGGCCCTTCGCGGCGTTGCCCCCGGCGGTGCAGGCGCTGTT
+CGTGCAGGCGTTCGCGGTGCCGGTGGTCCCCCGCCCATCTCCCGAAACCTGGGCAGCGGC
+GCTCGGCGCTCTGGCCGCCGAACTGGTGCCCTGTGCCCGCCGCGCCGGTCACTGGCAGGT
+GCCGGGGCTCCCTTGCCCGAGTTGCGCCGCCGAGCGCGAGGGGCCGGCGCCCAGCAGCGG
+GGAAGACGTAACGGCGCGGGTGCAGCGGCTGTGGAACGACGTGCAGCGAGTGGTCGCGCC
+GCCGCCGTCGCCCCCGGTGGCCCCGGTCATCGAGGCGCCGCCGCTGCCCCCGCTGCCGCT
+GGCGCTGCCCGACAAACCACGGGGTTTAAACCACCGCCAGCAGTTGCAACTCCTGACCTG
+GACGCTGCGGGTCGCCGTCCTCGCCGCGCTGATGCTGGGGGTCGGGCTGGTGCAGCGCTC
+GGTGCTGGCGGGGCTGGTGGTGCCCGCACTGATCGTCTTTGCCCTCACGCTGGGGCGGCG
+CTTTGCGGTGGACTGGGACGGCCTGATCGACCGTTACGAGCGCTGGGAACACGACCTCGT
+GCGGGGGCTGTTGCCGCGCCGGGGGCCGCAGCAGCGCTACCGCCGGGCGGTGCGGCGGCG
+CCGGGCCGAGGTGAAGACCGAGCTCGCCGCCCGCGTCGCCCAGCGCGAGGAACTGCGTGA
+GCGCTACCACGTCGAGAACGCCGCCGCCCTGCACCTGCGCGAGCAGCAGGCGTTGGAGCA
+GCGCCGGGCGCACCTGCTGAGCCTCAGCGCGGGCGGGAGCCTGGAGGCGCTACTGGGCCG
+CTGGCGCGAACGCTCCCGGCAAGACTATTTGCGCCAGCAGCAGCTCAGCAGCAGCGGCGT
+GCCGGGCGTCGGCCCCCGCGAACTCGGGCTGGCGGTGGCGCAGGGCATTCGCACCGCGTT
+GGACGTGACCGCCGAGCGGGTCCGCGCTCTGCCTGCCCCGCTGGGCCGCGAGTTGCTGGC
+GTGGCGGCGCGGCCTGGAAGACTTTTTTCAGTTCGACCCCGGCGCAGTGCCCCGCGCCGA
+GCTCAACGCCGTACAGCAGCGCGGGCAGCAGCACCTCGGCGACGAAATCGAGACCTTCGA
+GCGGGCCGTTCATGCCTACACCAATGCTCGCTGGGACCGCCACGAGGCCGAAATTTCCCG
+GCAACTTGGCGTCGTCGAGCGCGAAATCGAGCAGTACAAAAAGGCGCTGAGCGAACTGCG
+GGCCATCAAGGTCTGAGCCTGTGCTGTTTGGCACTTTTTCGCCTTCTTTGCACCCCGTCT
+CAACATCGCGGGGGCGAGCACAAGGGCGCGAAATACTCTCTTGACCCCGTGTCGCGCCTG
+ATTGGTCCGGCTCGCGGGGCACAAGGTGAACCATGACTGACAAGGCACAGACTTCTCCGG
+CGCGCCTGCCCCGCATCATTCAGGGGGGCATGGGCGTGGCCGTTTCCGACTGGCGGCTGG
+CGCAGGCGGTGTCGCGCACCGGCGAACTCGGCGTGGTGTCGGGCACCGGCATCGACAACG
+TGCTGGTGCGGCGCCTTCAAGACGGCGACCCGCAGGGCCACGTCCGCCGGGCGCTCGCCG
+AGTACCCCAACCCGGCCAAAGCGCAGGAATTCATCGCCAAGTATTTCCTCGAGGGAGGGC
+GTGCCGAGGGGCAACCCTACGCCCGCGTGCCGCTGCCCAGCCACCGCAACCACCAGCTCG
+CCTGGGAACTGTCTATCGCCGGGGCCTTTGTCGAGGTCTGGCTCGCCCGCGAGGGGCACA
+GCAATCCGGTGGGGCTCAACCTGCTCACCAAGCTCGAACTGATGACCCTGCCCTCGCTCT
+ACGGCGCCATGCTCGCCGGGGTGGACACGGTCATCATGGGCGCGGGCATTCCGCGTGAAG
+TGCCCGCCGCGCTCGACAACTTCGCGGCGGGGCGGCCCGGCACCTTCAAACTCAGCGTGA
+AGGGCGACCCACAGGGCGACACGCCGGGCGTGACCCTCGACCCCGCCGCTTACGGCTTTG
+ACGGAGTGACCACTGGGCGCCCGAAGTTCTACCCCATCGTGACCTCGCACGTGCTCGCCG
+GGGCGATGCTGCGCAAAAAGACCGGCGGCATCGAAGGCTTTATCGTCGAAGGCCCCACGG
+CGGGCGGCCACAACGCGCCCCCGCGCGGCAACTACGCGCTCGACGACCTCGGCCAGCCGG
+TCTACGGCGAGCGTGACGTGTGCGACCTCGGCGAAATGCGCAAATTCGGCGTCCCCTTCT
+GGCTGGCGGGCGGCTACGGCAAGCGCGGCGGCCTGCAAGACGCGCTCGCGGAGGGCGCTG
+CCGGCATTCAGGTCGGCACGCTGTTCGCCTACGCCCAGGAAGCGGGCATCCGCGACGAGT
+TGCAGCGGCGGGTGCTCGGCGAGGTGCAGCAGGGCGACCTCAAGGTCTACACCGACCCGC
+TCGCTTCGCCCACCGGCTTTCCCTTCAAGGTGGTGCAGCTCCCCGAAACACTTTCCAACC
+CTGAGGTCTACGCCCGCCGGATGCGGATTTGCGACATCGGCTACCTGCGCGAAGCCTACT
+GGGACATGGCCCCCGGCAAGGAAGGCAAAGTGGGCTGGCGCTGCGCCGCCGAGCCGGTGG
+ACCAGTACGTCGCCAAGGGCGGCAAGGTCGAGGACACCGTGGGCCGCAAGTGCCTGTGCA
+ACGCCCTGATGTCCGACGCGGGGCTGCCACAGATTCAGAAAAACGGCGACGTGGAAAAGT
+CCCTGCTCACCAGCGGCGACGGCCTGACCGAACTCGGCAGCTGGAAGCCGGGGTATACGG
+CGGCGGACGCTATCGAGTTTTTGCGCGGCTGAGGTGCGGCGAAGCAGGCTGGTCTCCTTC
+CTGCTGCTCGCCGCTGCCGTAGTGGGAGCAACGCTCAAGGTGGTGAAGGATGACCGAAGC
+GCCGTCCGCCTACCCCCTGCCGTGTACGTTCCGCCAAGCGGTCCCTTGATTGAGCCCAAG
+GAAAATGCCGGACGTTGCCTTGCCACCGCCAAAATCACGCTGCCCAAGTCCTACAACGCC
+TTTGCCAACCACTGGCGTTTTACGGAAGCTAAACAACTGACCGCCGAAACCTGGCAGATT
+CGCGGCGAACTGAGCGAGTATTCGGCGACGGGCGTCAAGGTGTTTATTTTTCAGTGTGTG
+GATAGCAATGAAGCGACGGGGGTAGAGCTTCACCCGAAGTAAAAATTGGGCAAGTTGGGG
+GCCAGGGCTGCGGCGTTGGCCCCTTTTTCCTATTGTCCGATCTCCCCCAAAATCTCCCCA
+ATCACCTCTTCCAATCCCAGCGGTCCGGTGTCGATCACGCGGGCGTCGGGCGCGGGGGCA
+CTCTGGGCGGCGTCCTTCCTGTCCCTGGCGATGAGGG
+>NODE_7_length_39998_cov_63.2738_ID_13
+CTACTTGCTGTAGCAGCAGGACAAAAGGTAATTGATCAAGTTACTAATCATTCACCTTTT
+ATGGAAATGATCATTGTTTGGATTGTGGCGACGACATTTCAACAATTTTTACCATCCCTT
+TCGACAATGGTTCAAGGAGTTCTAACTGATAAATTAACAGGCTTTATCAATATTAGCTTG
+ATGAAAAAATCAGCAGACTTACAATCGATCAGTATTTTTGATGATAGTAAGTATTTTGAT
+GATTTACAAATGCTCAGAGATGATGCAAGCTGGCGTCCGGTTAATTTAATTGTTTATGGA
+GTATCAGTCTTACAGTCATTTCTAACGCTAGCTTTCATGCTAATATATTTGGCACGATAC
+AATTGGTGGCTAGCCTTGCTTTTATTAGTAGTAATGGTACCGCAGAGTCTTTCTTACTAT
+CGTATTCAGCAGCAGTCATTTGAAACAATGGTTGAAAGAAGCAAGAATGCGAGATACTTG
+CACTACTATAGTGGATTGTTGCTTGATCGCAGGGATGCTAAAGAAGTTAGACTTTTCAAC
+ATGTTTCCTAAGATCATCGAAAAGTATACAAGCTTATTTGAACAAACGAAAAAAGACGTT
+AACCAAATTCGTAAAAAGCAACTTGCGACTAGTTCACTGTTTGTTGTATTGACTGTCGGA
+GTGTTTGGCTATGGCTTTTATTGGTTTACTAATTCAGTAAGAACAGGTGCATTAGAAGTT
+GGCGTATTATTGATGTTTGTTTCAGTAATTGGCTATATTTCTACTAGCATGGCTCGGGTA
+GTAGAAGACAGCAGCTTGTTATACGATTCATTATTATGGGTTGAAAAATACTTTAAGTTT
+CTTGAGTATCAAGATGATTTCAAAAACGGTGGTCAGAACTTTCCTGATGATTTTGATGAT
+ATTAATATTAAGAATCTGTCTTTTACATATCCGTTTTCTGATACTGAAATTTTGCACAAT
+GTTAGTTTCTCAGTTAAAAGTGGAGAAAAAGTTGCAATTGTTGGAGAAAATGGGTCAGGA
+AAATCCACTCTGGTAAAGCTATTAATGCGTTTTTATGACCCGACTAATGGAAAAATTTCT
+GTTGATAATTATGATTTAAAAGACTTTAATATCTTCGACTTACATAAAAATTTATCAGCT
+ACTTTTCAGGATTTTTCTCGCTTTAAATTAACGCTTAAAGAAAACGTGATTACCGGATAT
+TCATTCAATAAAGGTAGGGTAAATAATGTTCTTAAAGCAGCAGGATTGGGTGATTTGCTA
+GCTAATGATCATCTTAATCTGAATACGATGCTGGCTAAAGATTTCGAAAATGGAACTGAT
+TTGTCAGGTGGTCAATGGCAAAAAATAGCTTTAGCACGAGACTTATATGCTAATGGCAAG
+ATTGAATTTTTAGATGAACCAACGGCAGCCTTAGATGCTAAGAGCGAATCGGAAATTTAT
+CAACGCTTTTTGAAAGAAAATGATAAAAAGACAATTTTCTTTGTTACTCACCGTTTGTCA
+GCAGTTAGATTTGCTGATAAGGTATTATTTCTTGACGGTGGAAAAGTTAGTGGATTTGAC
+ACGCATACTAATTTATTGCAAACTAATCCAAAATATAAAGAAATGTACGACTTACAGAAA
+AATGCATATCTGTAAAGTTAAATTTTGATAGATAATAAAATTCTTCATGCAAGCAGGCAT
+GGAGAATTTTTTTGCCTTTTAACAGTTAAGATTTTTCAGTGATTTTTACGTTATAATAGA
+ACATAGGTTTTTGGAAGAAAGGATATTTGGTAACGAATGGCAAAAAAAGATACGACACCA
+ATGATGAAGCAATACTACGAAATTAAGGAACAATATCCCGATGCGTTTTTGTTTTATCGT
+GTGGGCGATTTCTATGAATTATTTGAAGACGATGCAGTTAAGGGTGCACAAATTCTAGAG
+TTGACCCTAACTCATCGTTCAAATAAAACTAAAAATCCAATTCCAATGGCAGGAGTTCCT
+CACCTAGCTGTGGATACTTACGTTAATACTTTGGTGGAAAAGGGATATAAAGTTGCGCTT
+TGTGAACAACTTGAAGATCCAAAAAAAGCTAAAGGAATGGTAAAGCGTGGAATTATTCAG
+TTAATTACGCCAGGTACCATGATGCACGAACGTCCTGACCAAGCAAAAGACAGTAACTAC
+TTAACGTCAGTTATTTCAACAAATTCTGGCTTTGGCCTAGCTTACAGCGACTTATCCACT
+GGGGAAACTTTTTCCACACACTTAACTGACTTTGAAGGTGTCGCAAATGAATTATTATCC
+CTTCAAACAAGAGAAGTTGTGTATAACGGTCATTTAACAGAAGCAAACAAGGACTTTTTA
+AAGAAAGCTAATATTACTGTTTCTGAACCGGTTAAAGTAGAGGGCGAACATGCTGAGATT
+TCCTATGTAACGCAAAATTTAACTGACGATGCAGAAATTAAGGCTACCAAGCAACTAGTA
+GCTTATTTGCTGTCGACGCAAAAGCGTAGTTTGGCTCACTTACAAGTAGCACAAAGTTAT
+GAGCCTACGCAATACTTGCAAATGTCGCATACTGTGCAAACGAACTTAGAGTTGATTAAA
+TCAGCTAAGACTTCTAAGAAGATGGGATCTTTATTCTGGCTCTTAGATAAAACAAGCACG
+GCAATGGGAGGCAGACTTCTTAAATCTTGGATTGAACGTCCGCTTTTATCAGTTACTGAA
+ATTACTCGTCGTCAAGAAATGGTTCAAGCGCTTCTTGATGATTACTTCACCAGAGAAAAA
+GTTATCGACAGCTTAAAGGGTGTGTATGACTTAGAAAGATTAACTGGTCGAATTGCTTTT
+GGTTCAGTTAATGCTCGTGAAATGCTACAACTAGCGCATTCTTTAGGTGCAATTCCTGAT
+ATTTTGAATTCCTTGCTTGAAACAAATAATCCACATCTGCAAAACTTTGCTAAGCAAATT
+GATCCGTTAAAGGGAATTCATGATTTGATTGTTAACACTATTGTGGATAATCCACCACTT
+TTAACGACGGAAGGTGGCTTGATTAGGGAAGGAGTTTCAGACCAATTAGACCGCTACCGT
+GATGCCATGAACAACGGTAAAAAGTGGCTATCTGAAATGGAAAGTCACGAGCGTGAAGTA
+ACTGGAATTAACAACTTAAAGGTTGGCTACAACAAGGTCTTTGGCTACTATATTGAAGTT
+ACGAATTCCAATAAAGATAAGGTGCCAACTGATCGCTACACTAGAAAGCAAACATTAACT
+AATGCAGAGCGTTATATCACGCCTGATTTAAAGGAACATGAATCCTTAATTCTAGAAGCG
+GAAGCTAAGTCAACAGGCTTAGAGTATGACTTGTTTGTAAAATTAAGAGAAAATGTTAAA
+AAGTATATTCCAGCTTTACAAAAATTAGCTAAACAAGTTGCCAGTTTAGACGTTTTGACG
+AATTTTGCGACAGTTAGTGAACAAAATAATTATGTTCGTCCAGACTTTACGGTTGATAAG
+CAAGAAATTAATGTAGTTAATGGTCGCCACCCCGTTGTTGAACAAGTGATGACGGCTGGT
+AGTTATATTCCTAATGACGTGAAGATGGATCAAGATACCGATATTTTCTTAATTACTGGA
+CCTAATATGTCTGGTAAGTCTACTTATATGCGTCAAATGGCCTTAATTGCAATCATGGCG
+CAGATTGGCTGTTTCGTTCCAGCAGATAGTGCAACGTTGCCAATTTTTGATCAAATCTTT
+ACTCGAATTGGTGCAGCAGATGATTTGATTTCTGGTCAGAGTACTTTTATGGTAGAAATG
+AGCGAAGCTAATGACGCTTTGCAGCATGCGACAAAACGTTCTTTAGTTTTATTTGATGAA
+ATTGGACGAGGTACTGCTACCTATGATGGGATGGCCTTAGCCGGAGCAATCGTGAAGTAT
+CTTCATGATAAGGTCGGGGCAAAAACGCTCTTTGCGACTCACTACCACGAATTAACTGAC
+TTAGACCAGACTTTAAAGCATTTAAAGAATATTCACGTTGGGGCAACCGAAGAAAATGGC
+AAGTTGATTTTCTTACATAAGATCCTACCAGGACCAGCAGATCAATCTTATGGTATTCAC
+GTTGCTCAATTGGCAGGCTTACCGCATAAGGTTTTAAGAGAAGCAACTACGATGCTTAAG
+CGATTAGAGAAGCAAGGAGCAGGAGAGTTGCAGCCAGCTAGCGAGCAACTTGATCTCTTT
+ACTGCTGAAGAAGCGAGTGTACCTGCAATTTCAGATGATGAAAAAGATGTCTTGGATGAT
+ATTCAAAATGTATATCTTGCTGACAAAACTCCTTTGCAGGTTATGGAACTTGTAGCTCAA
+TGGCAGCAAGAGTTGAAAGATAAGGATTAATAATCATGAGCAAAATTCATGAACTTTCAC
+CTGAATTAACTAATCAAATTGCTGCTGGTGAAGTTATTGAACGGCCAGCTAGTGTTGTTA
+AAGAATTATGTGAAAATTCCCTTGATGCCGGTAGCAGCCGCATTAGAATTAACTTTATTG
+ATGCAGGCTTAAAGCAAATTACGGTGCAAGACAATGGGAGCGGAATTGCAAAAGACCAGC
+TTAATTTAGCTTTTACTCGGCATGCAACAAGTAAGATTGCAACAGAGCGAGATTTATTTA
+ATATTTCTACTTTAGGCTTTCGCGGAGAGGCTTTAGCGTCAATTGCGGCCGTTTCTCATG
+TGGAAGTAATGACTAGTAGCGATAATTTAGGCGGAGTTCGGGCAATTTTTGTAGGTAGTG
+AAAAAAAGCTCCAAGAAGATGCTGCTTCACCAAAGGGAACCAAGATTTCAGTTAGTGATT
+TATTTTTTAATACGCCAGCTAGGCTGAAATATTTACGCTCTGAAAGAACTGAAACTCTAA
+AGATTGTCGATATTGTTAACCGACTTGCTTTAGGACATCCTGATGTTTCTTTTACTCTTA
+CTAATAATGGTAAGATCTTATTAAAGACCAACGGACGTAATGATTTAAGACAAGATATTG
+CAAATATTTATGGCCGTCAACTTGCAGAAAAGATGGAGGTTTTGAAAGGAAGCAGTCCTG
+ATTTTAAGATTACCGGCTTACTTTCTGATCCTAATACAACTCGTTCAAGTCGAAACTTTA
+TTTCTTTATTATTGAATGGCCGTTATATAAGAAATTACCGTCTAACTCAGGCGATTATAG
+CTGGATATGGCAGTAAATTAAGACCACGCCGTTATCCAATTGCTGTTGTAAACATTGAGC
+TAGATCCACTTTTAGTGGATGTTAACGTCCATCCAACTAAACAAGAAGTGCGCTTGTCAA
+AGGAGCAGGAATTAGAGCGCCTGTTAACTACAAGTATTTCAGAAGCCTTAGATCAGAATA
+GTCAGATTGATTCAGGTTTGAATAATTTATTAACTCCTAAAAAGTCGACAAATATTGACC
+AATTAAAATTTAACTTAAATAAAGATGTGGTTGATACTGTTCGTCCAGTCGAATTTACTC
+CGCAAGTTGAAGCTGATAAAAGTGCTGAAGTTCATGAAACAGCGGCAAGTTTTGTTAGCT
+TAGATAAGGTTCGTAATGACGATAAATATGTGATTACTGCAACTTGGGATGAAAATGTGG
+ATAAGCAGGTGCAGCTAAGTCCATTTGATGAGGAAAAAGATCTGCAAGGAAAAGATGATA
+GCATTATTTCTTCAGGGGATGAAATCTTAGCTAATAGCCTACCTGAATTAATTTATTTAG
+GTCAGACTAAATCATATTTAGTTGCACGTCATGATGAGGACTTATACTTAATTGATCAAG
+TAGCAGCTTATCGACGCTTAGCTTATGATCAAATTTTTCGTGATTTAAATAGTGAAAATA
+TTTCTCAGCAAGGTTTACTTAGTCCTTTAATTTTAGATTTTAGTAATGTTGACTATTTGA
+AGTTAAAAGAAAATCTTAATAATTTACAAGAATTAGGGATATTTTTAGAGGATTTTGGTC
+AAAATAGTCTGATCTTAAGAACCTATCCAATTTGGCTCCAACCTGACGTAGAAAAAAATG
+TCCGCATGATTTTAGATTTATATTTAAATCAAAATGAACAAGATTTTACCAAGCTTAAAG
+CACAAATTGCTGGTGAAATAACGCTGCGTCAAAGTACTAGAAGAAGAAATCTAAATCCAG
+TTGAAGCACAAGAATTATTGAAAAATTTGAGAAATAGTAGTGATCCTTATCAAGATTTTG
+AGGGAAAAATTATTATTATTCAGTTAAGTGAAAATGATCTCAATAAGATGTTTAAAAAAG
+ATGAGTAGGTAAAATGTTTGAATATCTCAAAGGAATAGTAGCAAAAATCGATCCAGCTTA
+TGTAGTATTAGATGTAAATGGCATTGGGTATAAGATCCTTTGTCCCACTCCATATAGCTA
+TCAAGAAAATCAGCCAGCAACTATCTATGTTGAACAAGTTGTTAGAGATACAGGGATTAC
+CTTATATGGCTTTTTATCTTTAGAAGACAAAGAATTATTTTTAAAATTATTAAGCGTTTC
+AGGAATTGGACCAAAGTCAGCTGTGGCGATTATGGCGGCTGAGGATACAGATTCGTTAGC
+TAGCGCAATTCAGAATGGAGAGGTGAAATATCTAACTCGTTTTCCAGGGGTTGGAAAAAA
+GACTGCTTCTCAGATTGTCTTAGACTTAAAGGGAAAGTTAGGCGACTATGTAAAGAAATC
+AGCAGTTGCTACCGATCTTACACCGAGCCTGCAAGATGCTTTGCTTGCCTTGGTAGCACT
+TGGTTATACCCAAAAAGAAGTTGACCGAATTACTCCAAAGTTAGCAAAATTGCCTGAAAA
+TACTGCTGATGGTTATATTAAAGAGGCTTTAGCTTTACTACTTAAGAAGTAAAAGTAAAA
+ATTAGGTAAGGATAAGGAAGTGAAAGATGTGAATGATGAAGAACGAATTATAGGCGCTGA
+GAGTAATGAAGAGGATGAAACGATTGAATTGTCTTTGCGTCCGCAACTACTTGCTCAATA
+TATTGGACAAGATAAAGTAAAGAGCGAGATGAAAATCTATATTAAAGCGGCTAAGCAGCG
+AGACGAAGCTTTAGATCATGTTTTGTTATATGGCCCACCTGGTTTAGGTAAAACTACTTT
+GGCATTTGTAATCGCTAATGAAATGGGCGTTCACTTAAAGAGCACCTCGGGTCCGGCAAT
+TGAAAAGGCGGGCGATTTGGTGGCTCTGCTTTCGGAATTAAATCCAGGGGATGTCTTATT
+TATTGATGAGATTCACCGTTTAGCAAAGCCAGTCGAAGAAGTCTTATATTCGGCAATGGA
+AGATTTTTATATCGATATTGTGGTTGGAGAAGGACAAACAACTCATGCTGTACACGTGCC
+ACTTCCTCCATTTACTTTGATTGGAGCAACTACCAGGGCTGGTCAATTATCTGCGCCGCT
+AAGAGATCGTTTTGGAATTATTGAGCACATGCAGTACTATTCTATTGATGATCTAGAAAA
+AATAATTCAAAGATCAAGCGTAGTCTTTAACACTAAAATTGATCCAGAAGCTGCTATTGA
+ACTAGCTCGACGTTCTCGTGGAACGCCGCGTGTTGCTAACCGTTTACTTAAGCGGGTTCG
+CGATTTTGCGGAAGTAAAGGGAGAAGAAGCTATTTCTTTAGCAACTACTAAGCACTCACT
+TCATTTGTTAGAAGTTGACGATGAAGGTTTAGATCAAACTGACAGAAAACTTTTAAGAAT
+GATGATTGAAAATTATGGTGGCGGTCCGGTCGGGATTAAGACTATTGCAGCTAATGTTGG
+TGAAGATACAGATACAATTGAAGAAGTTTATGAACCATATTTACTTCAAAAAGGATTCAT
+TACTCGAACTCCTAGAGGGAGAAGCGTTACGCAAAAAGCTTATTTACAATTAGGATATCC
+ACCAAAAAAAGCAGAGTAAGTTTTTAGTTGGACCAAAAATACGGTATAATTATTATTTGA
+AAGTTAATTAATAAAAATAATGAGGTGTAATACTTTGAATACATTTTTCTTAGCACAAAG
+TGCTGCTGGTATGAATAACATGTTCATGATTATTGCAATGATTGCAATTTTTGTCTTCTT
+CTACTTCTCCATGATCAAGCCGCAAAAGAAGCAACAACAAGAACGGATGAAGATGATGTC
+TGAACTTAAGAAGGGCGATCAAGTAATTATGGTTGATGGCCTTCATGGTAAAGTTGATTC
+AATCAATGACGCAGATAAGACTGTTGTGATTGATGCCGATGGAATTTTCTTAACATTTGA
+AAGAATGGCTATTCGTCGCGTTCTTCCAACTGCTGCCGCTCCTGCTAAAGATGTTGAAGC
+TAATGAAGCAAAAGAAGAAAAAGTTGAAACAGAAGAAAAGCCTACTGAAAGCAGTAAACC
+GGAAGAAACAGCTTCTGATAAAACTGATGATACTAATTCTGAAGATAAATAAAAAAACGT
+CCGCAAGGACGTTTTTATTTTTTCATTGTCATGGCTTAGTATTGTAAAATATGAATTGGT
+AAAGTAAATTTTAATAAGTTTAATAGGTAGGTAGTTAGAATGGAAAATATTCCAGTTGTC
+ATGATTATTTTTGGTGGCTCGGGTGATTTAGCTCATAGAAAGCTTTATCCAGCCTTATTC
+AACTTATATCAAAAGGGATTAATTCATGATCATTTTGCCGTAATTGGTACAGCTAGAAGA
+CCATGGAGTCATGAATACTTACAAGAACAAGTTGTTGAAGCAATTAAAGAAAGCAACAGC
+AGCTTTGATGAGAAAGATGCAAAAGAATTTGCTTCGCATTTTTATTACCAATCACATGAT
+GTAACTGATGTTGATCACTACATTGCTCTAAAAGAATTAGCTACAAAGCTTGATAAGAAA
+TATCACGCAGAAGGCAACCGTATTTTCTACATGGCAATGGCACCAAGATTTTTTGGCACA
+ATTGCAACCCATATTAACGATCAAAAGCTAGTTGGGAGTGGTTTTAACCGCTTGGTAATT
+GAAAAGCCATTTGGTCATGATCTAGCTTCTGCTGAAAAATTAAATCAAGAAATTAGCGAA
+AGTTTTGCTGAAGATTCGGTATATCGAATTGACCATTATCTCGGCAAAGAGATGGTCCAA
+AATATTATGCCGCTTAGAATGACTAATCCAATTGTTAATAATATTTGGTGCAAGAAATAC
+ATTGCTAATATGCAAGTTACCCTTGCTGAAAGCTTAGGCGTTGGTACTCGTGGCGGATAT
+TATGAGACTTCTGGTGCTTTACGCGATATGGTTCAAAATCATATTTTTCAAATTATTACC
+CTTTTAGCCATGCCAGAACCTAAAGCCTTAGATTCAGATCATATTCATGAAGCAAAGCAA
+GAACTACTCGATAGTTTGGTCATTCCGACTCCAGAAATGGTAAAGCAGCATTTCTCACGT
+GGTCAATATTTAGCAAGTGATGATGAAGTGGAGTATTTAAAGGCCGATCAAGTTGCTCCT
+GATTCTAAAGTAGAAACTTTTGTTGCTGGCGAAGTTAACTTCAAGAAGGGTCCCGTAGCT
+GGTGTTCCAATCTACTTTAGAACCGGTAAGAAGATGAAAGACAAAGTTTCTAGAATCGAT
+ATTGTACTCCACCACATGAATAATTTATACGGCAATGCACATTCAAATAATATTTCAATT
+ATTATTGATCCAAGAAGCGAGATTTTCTTTACTATTAACGGAAAGAAGATTACTACTGAG
+GGCTTAAGAAGAGAAAATCTCAGCTATAAGTTCTCTAAGGAAGAAATGGCTCAAGTCCCA
+GATGGCTACGAAAGATTACTTCACGATGTCTTTGTAGCTGATCGTACAAACTTTACGCAC
+TGGTCTGAATTAAAGCAATACTGGAAGTTTGTTGATGCGGTTGAAGCTGCATGGCAAGAT
+GAAAATAAAGATATTAAGCAACTTGAGCAATATCCAAGTGGTGAATTTGGTACTGAATCG
+AGTAACCATATTTTTGAAAAAGATACTGAACACTGGATTTACCGTTAATGGATTTACTGC
+CTAAAAATAATACTAAGCGTAAGATTATTCATCTGGATATGGATGCTTTTTATGCGTCAG
+TAGAGATTCGTGACAATCCTGCTTTAAGAAATAAGGCTGTTTTAATTGGCGGCGATCCTA
+AGAAAAATAGGGGACACGGGGTTGTGGCAACTGCTAATTATGTGGCTCGTCAATATGGTG
+CTCATTCAGCTATGCCGACAGCTAAGGCAATTAGGTTAATTCCAGCAGAAAAACTGGTAA
+TTATTCAACCACATTTTGAAAAGTATCGGGCTGTTTCAGCTGAAATTCATCGTTTAATGC
+ATAAAATGACTGATCGAGTAGAATCGGTTGCCTTAGATGAAGCATACTTAGATGTAACTG
+AGAATAAACTTCATCTAGCTGATCCTGTTCGGATTGCGACTATACTTCAAGAGCAAATTT
+ATCAAAAGGTTGGATTAACAAGCTCATTCGGCGTTTCTTACAATAAGTTCTTAGCCAAAA
+TGGGATCTGAATATGCTAAACCCTTTGGCAGAACCGTAATTCGGCCTGAAACTGCACTTG
+ATTTCTTGGCAAAACAAAAAATTGAAAAGTTCCCTGGAATCGGTCCTAAGACGCAAGAAA
+GATTAGCAGAGATGGGAGTCTACACTGGAGCTGACTTAATAAAAATTCCAACGGATGTGT
+TGATTAAGAAATTTAATCGCATGGGCTATTTGATCGCCCAACATGCACATGGCATCGACT
+TACGAGCGGTAGTTACTGATTCAGAAAGAAATCGAAAGTCGATTGGGATTGAGCGAACTT
+TTAATCAGAGTTTGTTTGATGAAAATGAAGCTTTAACTAGACTGCGAGCTTATAGCGGTG
+AACTTGAGAACCGGTTGAAAAAGCGACATTTTCTTGCTAATTGTGTTGTCTTAAAGATTC
+GCGATGCTAATTTTAAGACAATTACTAAAAGAAGAAAGCTAAAACAAGGCACGAATGATA
+AAATTGTTATTTACGACACTGGTCGTGTTTTGTTTGAAACAGAAAAAGGGATGCTCACAA
+CTGGAGTACGTTTATTAGGTCTTACGGTAACCGATTTTGAAGAACATCCAGTTGAGAATT
+TATCGTTAGATATTTTTGAAAACAAGTAATGATAAAATAAATTTAGTAAACAACAAGGAG
+AAAAGATTAATGGCAACTTTTGATGAAATTTATGAAAAAATAAAAGAATACCCAACAATT
+ATTTTGCACCGTCACACTAGTCCTGACCCAGATGCAATTGGTTCTCAAGCTGGTTTAGCA
+AGATCATTGAGATTAGCTTTTCCAGATAAAAAGATTCTTTGTGCTGGTGAAAATGACGAA
+GGTGACCTGATCTGGATTAATAAGATGGATGAAGTTACACCTGAAGATTATCAAGGTGCT
+TTAGTAATTACTACTGATACTGCTAATACTCCACGTATTTCTAACAAGAATTACGATAAG
+GGTGATTTTTTGATCAAGATTGACCACCACCCAGATGTAGATCCATATGCAGATATGAGC
+TATGTAGATCCAGACGCACCAGCTGCTTCAGAAATTGTTTTTGACTTTTTGAAAGCAGAG
+AACTTGCCAGTTACTAAGGAAGTTGCAGCAGCTTTATATGCAGGTATTGTTGGCGATACA
+GGTAGATTTATGTATCCTGAAACTTCAGCTCACACTTTTGACGTTGCAGCTGAATTAACT
+AAGACAGGAATTAACATTACTGATATTGCTAGAGAAATTGCGGATGTTACTTTTGATGAA
+GCAAAATTGCAAGCTTTAGCAATGGATAAGATGGAAATTAACCCAGTTGGAGCAGCTTAC
+ACAATTTTGATGCAAGACGATTTGAAGAAGATGGGCTTAACTGATGACCAAGCAAACGTT
+GCTGTTTCAACTCCAGGTCGGATTAAGGACGTGTTAGCTTGGAATGTATTTGTTGAAAAG
+CCAGATGGTACTTTCCGCGTTCATTATCGTTCAAAGGGTCCTGTAATTAACCATTTAGCT
+GAAAAACATGATGGTGGTGGCCATGCATTAGCATCTGGTGCCAATGCCAAGGATATGGAT
+GAAGTAAAACAAGTCTTTGACGAAGTAGTAGAAGTAACAAAGAAGTACAATGAAGAACAT
+GGCACAAACAAATAGCATATTTCAAAGTGAAAAGATTAGACCAGAATTGCGAGCTGGTCT
+AGAAAAAATTAATTTTAGCAAACCAACTAAGGTTCAAGCTGCAGTCATTCCGGCTCTTTT
+AAGTAATAAAAGTGTTGTGGTTCAAGCAGCAACTGGTTCAGGTAAGACTCATGCCTACCT
+GCTCCCACTTTTGAACATGATTGATGAAAATGCCCCAGTAACGCAAGCAGTAGTTACCGC
+GCCTAGCCGAGAGTTAGCAAATCAATTGTATAAGGTAGCGCGTCAATTAAGGGATGCGAG
+TGGTCTAAATATTTCCATTGAATATTTGGGCGGTGGTAATGATCGTAATCGTCAAATTGA
+AAAAGCTGAAAATAGAGCTCCACAATTAATTATTGCTACACCAGGTCGTTTACATGACTT
+TGCCTCAAAGAAAGTCATTAATTTAGATAACGTCAAAGCCTTCATTATTGATGAAGCAGA
+CATGACGCTTGATATGGGCTTTTTAAGTCAAATGGATGAGATCATCTCTAAACTAGATAA
+AAAGGTCGTTTTAGGCGCTTTTTCAGCTACTATCCCAGTTAAGCTAGAGAACTTTCTCAG
+AAAGTATATGTCAAAGCCAGACTTTATTGTTATTGATAATCCAGCAATTATTGCTCCTAC
+AATTCAAAATGACTTAATTGATGTTGGTTCAAGAGATAAAAAAGAAATTTTATATAAGCT
+CTTAACGATGGGACAACCATATTTGGCCTTAGTTTTTGCTAATACTAAAAAGACTGTCGA
+CGAATTAACTAATTATCTTGAAGAACAAGGGCTTAAGGTGGCTAAGATCCACGGCGGGAT
+TACTGAACGTGAGCGCAAGCGTATTATTCGCCAAGTTAGAGAAGGGCAGTACCAATATGT
+TGTAGCTAGTGATTTAGCCGCTAGAGGAATTGACGTACCAGGAGTTAGCTTAGTAGTTAA
+CTATGAAATTCCTAAGGATCTTGAATTTGTCATTCACCGAATTGGGAGAACTGGTCGAAA
+TGGGCTTGAAGGTCATGCAATTACCTTGATCTATGATGAAGAGATGCCTCAAATTGAAGA
+CTTAGAAAAGCTAGGTATTCACTTTGACTTTAAAGAAATTAAAAATGGTGAATTAGTTGA
+AAGAACACACTACCATCGTCGTGATAATCGCCAAGCTCGGAGTCATAAGCTTGATAATCG
+CATGATTGGAATGGTTAAGAAGACTAAGAAAAAAGTAAAGCCTGGTTATAAGAAGAAAAT
+TAAGCAAGCTATTCAAAAAGATCGCCAGCAAAAGCGTAAGATCGAAGAGCGTCATCAGAT
+TAGAAAAGCTAAACGTAGACGTAAGCGTGAACGCGAACAAGCACGCGGTAATTTTGACAA
+CTAGAAAATTTGTAGTAAAATAAATCACGTTTAGGACATATTACTGAAGTATTTTCTTCA
+AAGAGAGGGCCAGGCAGGTGAGAAGGTCTAGAAATACTTAGTAATGCTACCTAATTTAAC
+TAAAGAATTAAATATTTAAAGAGGTAACAAACACTGTTGCAATCAAGGTGGTACCGCGCT
+GGGAGCGTCCTTGTTTTATGCAATAGTGTTTTTTTATTTGTAGGAGACTTTTTATGAAAC
+AATTGACTAGTTCACAAGTACGTCAAATGTTCTTGGACTTTTTTAAAGAGCATGGCCACA
+TGGTTATGCCAAGTGCATCATTAATTCCACAAGATGATCCAACCTTATTGTGGATTAACT
+CTGGTGTTGCTACGATGAAGAAATATTTTGATGGTTCTGTTGTGCCTAAGAATCACCGAA
+TTACTTCTTCTCAAAAATCAATTAGAACTAATGATATTGAGAATGTTGGTAAAACTGCAC
+GTCACCAAACTTTCTTTGAAATGCTTGGTAACTTCTCAGTTGGGGACTACTTTAAGAAAG
+AAGTTATCCCTTGGGCATGGGAATTTTTAACTAGTCCAAAATGGTTAGGCTTAGATCCAG
+ATAAGCTTTATGTAACTGTTTACCCTAAGGATACAGAAGCATATCATATGTGGCATGATG
+TTGTTGGCTTACCGGAAGATCACATTGTGAAGTTAGAAGACAACTTCTGGGATATTGGTG
+AAGGTCCATGTGGTCCTGACTCAGAAATTTTCTATGATCGTGGTCAAGAAAATAACGATG
+TTGCGGAAGACGATCCTGAAAACTTCCCAGGTGGGGAAAATGCTCGCTACCTTGAAATTT
+GGAACATCGTCTTTTCACAATTCAATCACTTACCAAATGGTAAATATGTTGATCAACCAC
+ATAAAAACATTGATACCGGTATGGGATTAGAGCGTGTTGTTTCAATTATTCAAGATGCAC
+CAACTAACTTTGAAACTGACTTATTTATGCCAATTATTAAAGAAACTGAAAAGCTAAGTG
+ATGGCAAGAAGTATGCAGCAAACAAGGAAGATGACGTAGCATTTAAGATTATTGCTGACC
+ACGTTCGTGCTGTAAGTTTTGCGATTGCTGATGGGGCTCTTCCTTCAAACTCAGGTCGTG
+GATATGTTTTACGTCGTTTAATTAGACGTGCTGACTTGAATGGTCAACGTTTGGGTATTA
+AGGGCGCATTTTTGTACAAATTAGTACCTGTAGTTGGCGAAATTATGAAGAGTCACTACC
+CAGAAGTTGTTGATCAACAAGCATTCATTCAAAAAGTAATTAAGAATGAAGAAGAAAGAT
+TCCAAATAACGCTTTCATCTGGTTTGAACTTGCTTGATAATATTATTGCTGAAGCTAAGA
+AGAGCGATGATAAGACTGTTTCTGGTAAAGATGCGTTTAAGTTATTTGATACTTATGGCT
+TCCCATACGAATTAACTTTTGAAGCTGCTCAAGATGCAGGTCTTAAGGTTGATAAGAAGG
+GCTTTGATGAAGAAATGAAAGCCCAAAAGGAACGCGCACGTAAGGCTCGTGGTAACTTAC
+AATCAATGGGTTCACAAGATGTTACTTTGATGAATATCAAAGACAAGAGTGAATTTGAGT
+ACGGTACTTTAGAAGAAAAGCATGCTAAGTTAATCGATATTGTTGTTAATGATAAGTTAG
+TTGATAAAGCTGACGGTGAACACGCAACTTTAATTTTTGATAAGACTCCATTTTATGCAG
+AACGTGGTGGACAAGTTGCCGATCACGGTGAAATTTTGAATCAAAATGGTGAATTGGTTG
+CTCGTGTAACAGATGTACAACATGCACCAAACGATCAAAACCTACACTTTGTTGATATTA
+TTTTGCCACTTGAAAAGGGACAAGAATATATCTTGAAAGTTGATCAAAAACGTCGTCGCG
+GCTTAAAGCACAACCATACTGCTACTCACTTATTGCATGCTGCTTTACGTGAAGTTTTGG
+GTACTCACACTCACCAAGCTGGATCTTTAGTTGAACCAGATTACTTACGTTTTGACTTTA
+CTAGCTTAGAGCCAATGACTAAGAAGGAAATTGCTAACGTTGAAAAGATCGTTAACGAAA
+AGATTTGGGAAGAAATTCCAGTTAAGACAACAGTTACTGATCCAGATACTGGTTTGAAGA
+TGGGTGCTTTAGCCTTATTTGGTGAAAAATATGGTGACACAGTTCGTGTTGTTCAAATTG
+ATGACTTCTCAACTGAATTCTGTGGTGGTACCCACTGTGAAAACACTGACCAAATCGGAA
+TGCTTAAGATTGTTTCTGAATCTGCTGTTGGTGCTGGTACTCGTAGAATTATTGCTGTTA
+CTGGTCCAGAAGCTTACAAATATGTAACAGACCGTGACGAAATTTTGAAAGAAGTTCAAG
+ATGAAGTTAAGGCAACTAAGGCTGAAGATGTAACTAACAAGATTTCTTCTCTTGAAGAAG
+ACTTACGTGCAAGTCAAAAAGAAGCTGAACAATTAAAGGCACAAATTAACAAGGCTAAAG
+CCGGCGACTTGTTTAATGATGTTAAGCAAGTTAAAGGTTTAACTGTAATTGCTGCTCAAG
+CTGATGTAGAAGGCATGAATGATTTACGTGAACTTGCTGATAACTGGAAGAGCAGTGATA
+AATCTGATGTGTTAGTTTTAGCTGCTGAAGTTAATGGCAAAGCCAACATGGTTATTAGTT
+TGAACGATAAGGCAATTAAAGCGGGTCTTAAAGCCGGCGACTTAATTAAGACTGCTGCTC
+CAATCTTTGGTGGTGGCGGTGGCGGTCGTCCAAATATGGCACAAGCTGGTGGTAAGAACC
+CAGCAGGCTTAAAGGACGCTATTGCTAAAGTGTTACAAGAAGTTGAAGAAAAACAAAATT
+AATTGAGTTCGTTCGATATTTCAAGTAAAATTAAGAAGATAGGAGGAATTTTATTATGAG
+TTCGCTAGATAAAACGATGCATTTTGACTTTAACCAAAATAAGGGTAAGAATGTATACGA
+TACTCTACAAGACGTATACAATGCACTTGAGGAAAAGGGCTACAGCCCAATTAATCAAAT
+TGTTGGTTACTTACTCTCAGGCGACCCTGCATATATTCCTCGGCATAATGATGCCCGTAA
+TTTAATCTTGAAACATGAACGTGATGAAATTATTGAGGAATTGGTTAAGAGTTATTTAGG
+TAAAAATAAATAATGCGATTACTTGGACTAGACGTTGGCTCTAAGACTGTGGGGGTTGCA
+ATTAGCGATCCTTTGGGAATCACTGCTCAAGAGCTTGAAACAATCAAAATTGACGAGAGC
+AAGTTTAGTTTTGGCATGCGCCAAATCAGAAAGCTTGTCCGTAAATACGACGTCGAAGGT
+TTTGTTTTAGGGCTACCCAAAAACATGGATGGCAGTAGTGGACATTCTGTAGAAAGAAGC
+AAGCAGTACGGTGAACGCTTGAAAGAGAAGTTTGACTTGCCTGTTCATTATATGGATGAG
+CGGCTTACAACCGTACAGGCTGATCGTATTCTGGTTCAAGAAGCCGGCGTACATGATCGT
+GTTGAAAGAAAAAAAGTTATTGACCAAATGGCTGCTGTTTTGATTTTACAAAGTTATCTA
+GAAGCAACCAGAAAGGATAAGTAAAATGAGTGAAAAAATTAACGCTAACCAAGATAATGA
+TCGTCAAATCACTTTAGTTGATGATCAAGGCAATGAAGAACTTTTTGAAATATTGTTCAC
+TTTTACGTCTGAAGATTATGGTAAATCTTATGTTTTACTATATCCAGCAGCCGTTAGCGA
+CGATGATGATGTCGAAGTACAAGCTTTTAGCTATGATGCAGATGAAGACGGTGATGTAAC
+CAGTTCTGACTTACACGAAATCTCTGATGATGACGAGTGGAACATGGTACAAGGCGTTTT
+AAATACATTTTTGTCAGACGATCGCTTAAGTGGCGAATAATCTTCAAAAAAGACTGGCGC
+AGAAAGGCTAGTCTTTTTTGCTTAATAAGGATGAACAATGATTTCTATTCTCATTTTATT
+AATTTTTATTTATTGTTGTTATGTAGGTTATCGACGTGGCATAGTGTATGAAGGCTTAGC
+TGCAGGTGGATATGTAGTAGGGTTAATCTTGGCAACATTATTATATAAACCTTTTAGTAA
+CTTCTTAAATCTTTGGGTGCCATATCCCTCAGCAAGTGATCGAAGTAGCTTTGCTTTCTT
+TGATAAGACTACAGGATTAACATTAGATAAGTCATTTTATGCAGCAATAGCTTTTTCAAT
+TGTTTTGGTGCTTGTTTGCTGTATATGGCGTTTGGTGATGTTAGGTTTTAATCAGTTAAG
+ATATGTTACTGTAGATGCTAGATTAAATACATGGGGCAGCATTATTATTGCTTTTATTGT
+GACCCAAATTAGTGTTTATTTGCTTTTATTTATCTTAGCTACGATTCCTAACAATAGTTT
+GCAAAATATGCTGGGGCATTCTATTTTAGCAAGTGGTATCTTGCATTTCTCTCCAGGAAT
+TTCGCAAATTTTCATAAAATTATTCATTACAACAATATAAAAGTGGGCCCAGCTACGGGG
+CCCTTTTTGCTAGGTGGAAGATATGAACTCTAAAATTATTGAAAAATTAGAATATAATCG
+CATAATTAGACAATTAAGTGACTTGGCAATTACTGCACCTGCAAAAGCTCAGGCTCTGAA
+ATTAATGCCAAGTAGTGACTTTGATGAAGTAAAAAAATCAATTGATCAAACTAGAGTACT
+TTCGAATATCTTGCGAGTTAAGGGGCCAATGCCGATAACTGACTTTAAAGATGTTCGACC
+TAGTTTGAAGCGATTGAAAGTTAAGGCTAACTTAAATGGTGAAGAATTAGGTAATATATT
+TCTAGTTCTTAGTTTGGCTAAAGATGTAGGACAATTTGCATCGGACCTTGAAGAGCGTGA
+AATTGATACACGTCCTATTGAAAAGTACCTCAAAAATTTAGCAGTTCCAGAAGATTTGTT
+TAAGAAGTTAAATCAAGCAATTGAATATGATGGAACAGTTAAAGATACAGCTTCTTCTAA
+ATTGATGCAGCTTAGACATGATATTCAGAGTAATGAAACTGATATTAAGAACCACATGAA
+TGACTATATTAGTGGCAAGCATACGCAATATTTGTCAGAAAATATTGTGACTATCAGAGA
+TGGACGTTATGTTTTGCCAGTAAAACAAGAATATAAAAATAAATTTGGTGGAGTTGTTCA
+TGATCAAAGTGCTAGTGGTCAAACTTTATTTGTTGAGCCACAAGCAGTCTTGGTACTTAA
+TAACCGTCAACAAAATTTGCTGGCTCAAGAACGCCAAGAAATTCACCGTATTTTAATCGA
+GTTATCCGAACTTGCTGGTGCTTATCAAAAAGAAATTAATAATAATGCATTAGCATTAAC
+TCAATTAGACTTTTTAAGTGCTAAAAGCAAATTAGCTAAGAAGATGAAAGCGACAGAGCC
+TGTCTTAAATCAAGATCATATCATTAAGTTGAGAAAGGCACGCCACCCCTTAATTGATCC
+TAAAAAGGTAGTACCAAATAATATTGAATTAGGAACTACTTTTGATACTATGCTAATTAC
+AGGACCAAACACTGGTGGTAAAACTATTACCTTAAAAACTTTAGGATTGCTACAATTAAT
+GGCTCAAGCTGGTTTATTTATCACAGCTGAAGAAGGTAGTCAATTAACGGTCTTTAATGA
+AATCTATGCTGATATTGGAGATGAACAATCCATTGAGCAATCTTTGAGTACATTTTCATC
+GCATATGGATCAGATTATTAAAATTATGAATAATGTTACTGAAGATGATTTAGTTTTAAT
+TGATGAACTTGGTGCTGGAACTGATCCAGAAGAAGGTGCAAGTTTAGCAATTGCAATCTT
+AGATGATTTACGCCAAACACAAGCAAAGATTGCGATTACTACACACTATCCAGAATTAAA
+GTTATATGGTTATAACCGCAAGCGAACTACTAATGCCTCAATGGAATTTGACTTAAAGAA
+ATTGGCACCAACTTATCGCTTGAGAATTGGAATTCCTGGTCAAAGTAATGCTTTTGCGAT
+TGCACATCAATTAGGAATGAATGAAGCTGTTGTAGATAAGGCTAGGGACCTAATGAATGA
+TGAAGACAGCGACATTAATAAAATGATTGAGCGTTTAACAGAACAAACTAAGGCAGCTGA
+ACAACTTCATGAAACTTTGAAGCAAAATGTTGATCAAAGTATCACCCTTAAACGTCAACT
+GCAAAATGGGCTTGATTGGTATAACCAACAAGTACAAAAGCAACTCGAGAAGTCTCAGGA
+GAAAGCTGATGAAATGCTTGCTAAGAAACGTAAGCAAGCTGAAAAGATTATCAATGATCT
+TGAAGAGCAAAGAAGAGCTGGCGGACAAGTTAGAACCAATAAAGTAATTGAAGCTAAAGG
+CGCTTTGAATAAACTTGAGCGTGAAAATCAAAACTTGGCTAATAATAAGGTGCTACAGCG
+TGAAAAAAAGCGTCATGATGTAAGTGTAGGCGACAATGTTAAAGTCCTGTCATATGGTCA
+ACAAGGTGTAATTACGAAGAAGTTAGGCGAGCATGAATTTGAAGTCCAAATTGGTATTTT
+GAAGGTGAAGGTAACTGATCGTGATGTTGAAAAGATCGCTGCACAAGCCAGTCAAAAAAA
+GCCAGAGAAATCTGTTCGCTCTAGTCGTGGTCTTCGTTCTAGCCGTGCAAGTAGTGAACT
+TGATTTAAGAGGGCAGCGTTATGAAGAAGCTTTGACTAACTTAGATCGCTATCTTGATGC
+TTCACTTTTGGCTGGGTTGAATACAGTAACCATCATTCATGGTATTGGTACAGGCGCAAT
+TAGAAATGGTGTTCAACAATATTTAAAGCGTAATCGACATGTAAAGAGTTATAATTATGC
+TCCAGCTAATCAAGGTGGAACAGGGGCTACAATAGTTAATTTGCAATAAGCAATATACTT
+GCAAAAAGTAAGTAATTATACTAAACTATACTTATAATTTAAAGAATTTATTTTGTGAGG
+TAATAACTATGGTTGATGAAATTACAGATGCAACTTTTGAAGATGAAACTAGCGAAGGTG
+TTGTTTTAACTGATTTCTGGGCAACTTGGTGTGGTCCATGTAAAATGCAATCACCAGTAA
+TTGACCAACTTTCAGAAGAAATGGACGATATAAAGTTCACTAAGATGGATGTTGACCAAA
+ATCAAGAAACAGCTCGAAACTTAGGAATTATGGCAATTCCAACTTTACTGATTAAAAAAG
+ATGGTAAAATTGTTGACCGCTTAACTGGTTATACTCCTAAGGAAAAGCTTGAACAAATCT
+TAGATCAATACACTGATTAATTTATAGTCAAAAAGGGTAAACCGCGATTGCGATTTACCC
+TTTTTGATATTAGTCTTTTTGTATTCATTAAGTTGATCAATCAGACTGAGCTGTAATTTG
+GACGACATGCTTTTTAGTAATCGTAGCTGAGGCCTCAGTAGGAGTGCCATTTTGGCGTTC
+TAAACATTCTGCAATAATTCCACTTTCCAATGAAAATTCATCACTTTGGCTATCTAGTCG
+ATCAGTAACAACTTGTCCTGAAAGTTCGAAAACTGCAGTGTGTTTACGATCCTTGAGTAC
+TTTTAAAGTTCCAAATTGAGCCATGTCAAAAAATTCGATCAAGTCATCGATGTCTGATAA
+GTCATATTTGCGACTGACGTGTTTACCGGCCCAGTAAAGAATTTCTTTATCTTCGCTACC
+TAAGATAGTAGGTAAGATAAAGTCACGGTATAATGAATTTAAAAAATAAAGATGTTCGTT
+TGTGTGTTCCATGCTTTCATTTCCTTTTGTCTTCTATAACATTTTAACTTAAAATAGGTG
+GAGGAGAAAAGAGATTTTAATCATCATTTGTTTAAAGGAGTTTTTTTAATGGATAATCGA
+CCAATTGGAGTTTTAGATTCAGGCTTAGGTGGCTTAACTGTTTTAAAAAAAGTAATTGAG
+AAGATGCCTAACGAATCAACTATTTTTATTGGTGACCAGGCTAATATGCCCTATGGAGAT
+CGCTCAAAAGAAGAGATTATTTCTTTAACTCGCGACAGTGTAAACTTCTTATTAAGTAAA
+GATGTAAAGATTATTATTTTTGGTTGCAATACTGCCACTGCGGTTGCAATGTCTACTATT
+AAAAAAGAAATTCCTTTGCAAATAATTGGAGTAGTTCAATCTGGTGCCTTAGCTGCAGCT
+AGAACCACAGAAACAAAGAATGTTGCGGTAATTGGTACTAAGGCAACTGTTAATAGTCAT
+TCTTATTTAAAAGAAATTCAATATCGTGATCCAAAAATTCAAGTAAGCGAATTTGCACAA
+CCTAAATTAGCGCCTCTTGCTGAGGAGGATCCTGCTGAAGAGATTAAGCAGGCTGTGGTC
+AGCGAAAGCTTAGCGCCGTTGAAAAAGGCTGATTACGATACCCTTGTTTTAGGATGCACC
+CATTATCCATTATTAAGAAAGGAAATTGTTGCAGTGGTTGGTCAAGATAGAAAGATTGTT
+GACCCAGCTGATCAGGTGGCACAATATACCTATAATGTTTTACGACGTGATGGTTTATTT
+GCGGCTGGTAATTCTGATACAAAACACGAATACTATACGACAGGTGAAGCTAAGAAGTTT
+ACTGAAATAACACGTCAATGGATGAATGATGAAACAATTGTTGGTCATCATGTAGATGCT
+GAGGATTAAAAATGGATACTTTATTATTTGCAACTAACAATAAAAACAAGGCTAAGGAAG
+TTGAAGAAGCCTTAAAAAAGAATAACTTTCCGATTCATGTGATTACTAATCAAGATTTGA
+CTGACCCACCACATGTGTTAGAAACTGGTACCACATTTTTAGCTAATGCCAAGCTCAAGG
+CTCACCAGATGGCAGAATTTAGCAATCTACCGACTTTAGCTGATGATTCAGGATTATCGG
+TCGATAAATTAAATGGTGCTCCTGGCGTTTATTCTGCGCGGTATGGCGGGGAAGCTCATA
+ATGATGCTCTGAACAATGCTAAATTATTAGCAGAATTAGGCGGGGTGCCAAAAGAAGCGA
+GAAAGGCTACTTTTCATACAACGATGGTTGTTTCTTGGCCAGGTAAATTTGAGGATGATC
+TAGTAACTGAAGGCGAAATTCGTGGTGAAATTTTAACTTATCCACAAGGTGAAGGCAATT
+TTGGTTATGATCCGCTTTTCTTTGTTTCTGATAAAGGAAAAACATTTGCTGAAATGACGG
+TGGATGAAAAGAATGCAATTTCTCACCGAGGTCAAGCTTTGAGAAAATTACTTGCGGAAC
+TACCGGCCTGGTGGAAAAAGATGGAAAACAAATAAATTTCGAAGAACTTATTCTGATTAG
+GGGATAAGTTCTTTTTGTTTTTTCTGCTTTTAATTATAAGTATGAAAGCGCTATACTAAA
+ATTGTGAGTTTACTTAATAAATGTAAGTTTAATTGAAATTGAGGTTATAGCGTATGAAAA
+AAGTTTTAGCAATTAATTCAGGAAGCTCGTCCTTTAAATATAAATTATTTTCTTTTCCTG
+ATGAAAAAGTTATCGCTTCAGGGATGGCTGATCGAGTTGGGATGGAAAATGCTGTCTTTA
+AAATTAAGTTGAGTAATGGGCGAGAATATATCAAAAATATGCCGATTCATGATCAAGAAG
+AGGCAGTGAAGCTTTTAATTGAGGATTTGAAAAAATTTCATGTAGTTGAAGATCTGAGAG
+AAATTACTGGAATTGGTCACCGAATTGTAAATGGCGGTGAAATATTTAAAGAATCAGTTC
+GTGTTGGTGACAAAGAGTTACAAGAAATATTTGATTTAGGTGAACTTGCGCCTTTGCACA
+ACATTCCTGAGGCAAATGGAATTAAGGCCTTTATGAATATTGTTCCTAATGTTCCACAAG
+TAGCAGTTTTTGATACTTCATATCATCAAACTTTAGATCCAATTCACTATCTATATTCAA
+TTCCTTATGAATATTATGAAGATTATGGAATTAGAAAATATGGTGCGCATGGAATTTCTA
+TTTCTTATGTTGCACCGCGTGCAGCCAAGATGCTTAAGAAAAATCCTAACTTAGTTAACT
+TGATTGTTTGTCACTTAGGATCAGGTGCTTCAGTCACTGCGGTTAAACGCGGAAAGTCTT
+ATGATACTTCAATGGGAATTAGTCCGTTAACTGGTGTAACAATGGGGACGAGAAGCGGAG
+ATTTTGATCCTTCAGCACTTCAGCGTTTAATGCATAAGACCGGAATGAATATTGATGAAG
+CAATTGATGTTTTGAATTATAAGTCAGGTTTATTAGGTATTTCAGGTGTATCTTCTGATA
+TGCGTGACTTAATTGAAAGTAAAGATAAGCGTGCCAAGTTAGCACGTAAGATATTCATTA
+ACCGTGTTGTTCGCTATGTTGGTGCTTATGCAGCAGAGTTAGGTAGAATTGATGCAGTTG
+TCTTTACTGCAGGAGTAGGTGAACATGATCCTGGTATTAGAGCTGGTATTATGTCCTCAT
+TAAGATATTTGGGGTTAGAACCAGATTTTAAGGCTAATCGAACAGATGGTGAAAAGTTTA
+TTTCTAAACCTAAGTCTAGAGTAAAGGCAATTATTGTCCCAACTAATGAAGAATTAATGA
+TTGCTCGCGAAGTAGTTCGCGTTGTGCAATAAAAAAGGATTAAGCAATAGATAAAAGTCT
+GGTTGCTTAATCCTTTAAGATGCAGAGCTATTTTCTTGTTTTGTTGGCATGGGACTGAAT
+TTAAGCCCGCGTTGATTGAATTCTTTGATATAAGCACTGAGATAGGCATTTTTAATCGTA
+CTTTGGCTATTTGCAATTACTTGAAAATGAATTTGATAGGTAATACTTGAGCCGGTTTGA
+TTAATGATTCCAATAATTTGAGGGCCCTTTTTGATTTGTTTTTTAAACTTATCTTTTAAA
+GCGGCGTTTACCGTATCAACGGCATGATTAATTTCAGTAAGATTATTTTCTACTGAAAGA
+TTTAAATTAATATCCATGCTCCAGCCAGAGTGTGAACCATGACTCAAATTTTCAACTACG
+GTAATGTTGCGATTAGGAATATAGATTACAGCGCCATTAGTAGTTTTAAGGCGGGTATTG
+CGCAAGGTAAAGGAGAGAACAGTTCCGGTGTAGTTGCCAATTTTGACAGTATCGCCGATA
+TTGTATTCACCTTCGCTTAAGATGTTCATCCCAGTTATGACATCGCTAACTAAGCCTTGT
+GCGCCCATCCCTAAAGCTAGAGATACTAATCCTACACTAGCTAATAGCGTTCCGACTGGA
+ATTCCCATTAACGTTAAAATACTATATAAATAAAATAAGAGAATAGTATATTGAAAAAGA
+GCAATTCCTAGTTGAGCTAAGGTTCTTTTTCTTCCAGTCATGCGTTCCTGAAATTTAGGA
+TTTTTTAATAGGTATTTTGTTAATAAGCGCTTTCCTATATGCCAAATTAAAAAGAAAATA
+ATTGTAGTAATAATAATTTGGATGCCACGGCTTAACAAAGTGTGCAGTACATTGTCCCAG
+TTAATTAGGTAATCGATATTATTAGTTTTTTTAGTTGTAGAAGTTCCTTTTAGAAGAGTA
+GACCAGTTCAACTCATGCCCTCCTTATCTAGTTTCTTTAAAAATAGTATATCAAAAACTT
+GGGTACTATTTCATTGCTTGAGGGGAGGAATAATGCTAGACTTTTTTATGAGAGGAATAA
+TTAATGGAGGATAGATTATGTCAATTTCATATGGTGCATTAGCTGGCTTAATTGCAGCAG
+TTGCCTTTTTAATCTTGGTCTTATTTACTTTACCTTTGATTGTTAGAGTTACTAAGACAA
+TGAAAAAAGTTGACTCAACTATGGACAGCGTTAATACGGCTGTTGATGATTTAACGAAAC
+AAACTTCTGTATTAATGAAGCAAAGTGAAGATTTATTAGAAAAAAGTAATGCTCTTTTAG
+CTGACGTAAATGGAAAAGTAACAGAATTAGAACCAGTTGTAAAGGCAGCAGCAGATTTAG
+GTGAAAGCGTGTCAGATATCAATTCTTCATCAAGAAGAATGGTTGAACGCTTCTCTGGTA
+TGGGTATTAGAGGAGCTGGAATTGGCATCTTTTCATCTCTAGTTAGTCGCATGTTTGCAA
+GACGTAAACGTCGTCGCGGTGAAGACTAATATTTATTAAAGGAGAACAATTATGCGTAAA
+CTTGGTGGATTTTTATTAGGTAGCGTTGTTGGTTTAGGTGTTGGCTTAATTGCTGGCTCA
+TTATTGTTGCCAGAAGACGCAACTGACGATGTAAAGAAAAAACTTGCTGAAAATGAAAAA
+TTGCAAGATTTGAAAGAAAAGTATGATAAAGGAACTGAAGCTATTAAGAATCAATTAGCT
+TCTTTCCCTAAGTCAGTTGAAGATGATTCCGAATTAAGAGATTTTGATGATATCGTAATT
+GATGACACTAACAAAGATCTTGGCGAAGATGAAAAATCTGACAAGGATGCTGTTAGCGAT
+TTAAACAATGCTGAAGATACTGAAAATAACTAAAATTAAATATTTATAAAGAGAATCAAG
+TTCTACTTGGTTCTTTTTTTGCAATAAAAAACCTGTTGATAAAATTTATCAACAGGTAAT
+TTTAGGCCTAGTCTTTAACTGGAATATATTTTAATTCCTTGCTTGTCTTAGTGAAGGTTT
+CAAAACCGTTTTTAGTGACTACACCACAATCTTCAATTCTAACTCCAGCTACGTTAGGGA
+TATAAATACCAGGTTCAATTGAGAAGCACATGCCTTCCTCGAGAACTACGTCGTTTCCTT
+CCATGATTTGTGGAAATTCGTGAACGTTCATTCCAATACCGTGGCCAAGACGATGAATGA
+AGTATTCACCATAACCAGCCTTAGTGATAATATTTCTAGCAACAGCATCTAATTCGCTAG
+CAGTAATGCCTGGTTTAGCTGCTTCAATAGCTGCTTGTTGCGCCTCACGGTCGACTTCAT
+AAATTTCTTTTTCTTTAGCAGTTGGTTCGCCGTAAGCGACAGTTCTACTTGAGTCAGAAG
+CATAGCCGTTGTGCATGGTTCCAAGATCGAATAAAACTAATTCGTTTGGTTCAATTTTGT
+TCATTGTTGGACCAAGGTGAGGGTTAGCAGCATTTGTACCAGCTTGGACAATTGTCTCAA
+AACTAGTGTGCATTACACCTTTTTGAAGCTTTAGTTGGTAATCAATTTGTCCAGCAACAT
+AACGCTCAGTTACGCCGTTTCTTAGGGCATTAAAACCAATTTGAAAGGCAAAATCAGCTT
+CTGCACCAGCAGCCTTTAATTGTTCCACCTCTTCTGGAGTTTTACGTAAACGTGCTTCAG
+CTACGAATGGAGAAACATTATTGGTAAATGAAGAATCAGGAAAGGCAATGCGTAATTGTT
+CTAAACGGTCAACTGAAAGATGCGATTTTTCGATTGCAATATTATTTGGTTTACCAACAC
+GTTGATTTACTAAATCAGCAATTTTTGCCCATGGGTTTTCATGGTCAAGATAGCCATAAA
+CATCGCCATCCCAAGCAGAGTTTTTAGCTTCTTCAACATTTAATTCAGGTGCAAAAATAA
+ATGCAGGCTTGTCTTTAAAAGCAATTAAAGCAAAAATTCTCTCATGTGGATCCATGCTAT
+AGCCGGTGAAATAATTAATACTGATTGGATCAGAAATATAAGCAACATCATTATTGGTTG
+AAATTAACCAATTTTGTAACTTGTCTAAGTTCATAATTTTGGCTCCTTTTTTAATATATA
+CTGGGAGTATACCATATAATATGGTAAAATAATGAGTTTTTAGTCGTAAACGGTTGCAAT
+GTGTGAATATTCTTGATAAGTTATAAAAGAGTGTTTTTACAGGAGTGTGAGAAATTTATG
+CAAAAGCAAGAAGTAACAATTTATGATGTTGCTCGTGAAGCAAAAGTTTCTATGGCTACT
+GTTTCAAGAGTAGTAAATGGAAATAATAATGTACGTAAAGAAACACGTGAAAAAGTATTA
+GCTGTCATTGATCGTTTGCATTATCAACCTAATGCAGTTGCTCAAGGATTAGCTTCAAAG
+AGAACTACAACAGTTGGATTGATTGTCCCTGATTTGACAAATATGCACTTTGCTGAATTA
+TCTAAGGGAATTGACGATATTGCTACAATGTATAAGTACAATATCTTACTTTCAAGTGTC
+GGAAATACCTTGTTAAATGAAGATCAAGTTATCCAAAATTTACTTAATAAGCAAGTTGAT
+GGTGTAATTTACATGTCAAACTTGATGAATGAAAAGGCACAAGAAATTTTCAATCGCACT
+AACACACCAGTTGTTTTAGCTGGTACTGCTGATGCTAACCAAGAATTTTCTAGTGTAACT
+ATTGACTATAAGGCTGTTGAAAAGGAAGCTTTAGGTCTTCTATTAAAAAATGGTAAGAAG
+AACTTGGCCTTAGTCGTAGGTGACGGAAAAGCTTATGTTAACAAGGACAACCGTTTCGTT
+GCCTATAAGGATTTCATGGAAGAACATAATTTAAAGAACGTTCACATCTATGAAGATGCC
+AAGACTTATGAAGATGGCTATGAATTATTTAAGCAAATCAAAGCTGATAATGTAGATGGA
+ATTATTGCTACTCGTGATGTAACAGCTGCAGGTATCGTTAATGCTGCTGCTGATGCTGGT
+GTAAAGATCCCAGAAGATTTAGAAATTATCTCCGCTGCTTCAACTAATGTCGCTAAAATT
+GTTCGTCCTCAATTAACAACTGTTCAACAACCGCTTTATGATATTGGTGCTGTTGCAATG
+AGAATGTTAACTAAGTTGATGAATGATGAAGAATTAGACGATTCACATGTTATCTTGCCA
+TATACTTTGAAGAAGTCTCGTTCTACTAAGTAGATCTAACTATAGAAAATCCCTTTAGGT
+AATTTACCTAAAGGGATTTTTTAATATATAATTTTAATTTTTCTACGGAGCAGTCGGACC
+ACTATCAGTGGCTGTATTGCCTTCACTAGTTTCGCTGCCAGTATTTGTATTAGCAGCTGA
+ACCTTCATTAGAACTAATATTTGAATTTACATCATTTGCGGCATTGTTGCTCTCGGAATT
+ACTATTTTCAGTTGAAGAAGATGATTCACTTGTGGAACTTGCACGACTCCGTCTGGTAGA
+AGTAGATGAAGAAGAACCATTACCATTTCCGCCTTGACCAGTACTTCGAGCTTGCTGATC
+ATTAGCTCCGACAGTCCGATTAGTCGAAGATGAGGAATTATTATTTGATTCACGATATAC
+TTCGTGGTTTTTACCATAGTAATTTTTAGCATCTTCTGAAGTTGAGACATCAGCTACAGC
+AAACAGACTGTTGATATTTTTCTTCTTAGAAATTGTCTTACCAGTGTAGATTAAGACTTT
+ACCATAATCATTATTCTTGCCTTCTAAGTAGTCGTAGAAGAGGTTGTAGTCTTTAGTTGA
+TCCACCGATACCAAATCTTGCAGTAGCAGCTGGAGCAGGGGATAAACTTAATGCGGTAGT
+CTTTTTACCAGAAAGTTCAATATTATCGCCATCATAGCTTACAGTTCCTGGCAATGTTCC
+AGTTCTTGCTAAGACTTTATTTTTATAAACAGAGCTTGGACGACTTGGTGCATCATTTAA
+CTTAAAGATTGACGGATCTTCTTCGTAAAGTGCATTGGCGATATTTGCCCAAAGGTTTAA
+GTTGGTTTCACTGGAATTAGAATCTAGGTTATATGAGTGACCATAGAAGTTGTCATACCC
+CATCCAACTAGAAATTGTGATTCCAGGAGTAGACCCATTGAACCAAATATCACGATAATC
+ATTACTGGTTCCAGTTTTACCGATTAAGTTCTTGTAGTTAAACTTCAAAGTACCAGTTAA
+GCTTGAAGCAGTACCCTTAGTTACTACTTGGTGAAGCATCTTTTGCATGATGTAAGAGGT
+GCCGGTAGAGAAGACTTTTTGTGGATTTTGTTTATGCTTATAAATTACTCTACCTGATGG
+ATCTTGAATTTCTTCAATGTAGTAAGGATCAGCTCGCTTACCATTGTTATAGAAGTTAGA
+GAAGGCACTAGCGTTATCAGCAACTGAAAAACCATAATCTGTACCACCGAGGGCCAAACC
+TAGGTTTTCAAATTCGCTTTTACTCAAGTTTAAGCCTAGTTTTTTCATATCCTGACGTAA
+ATTAATGTTCTTATCGTTGACTAATTTATTGTATAAGTTTACAGCAGGTAAGTTATAAGA
+TTTACTTAGAGCTTCTTGAGCTAAGATAAACCGGTTTTCAACAGTGGAATTGTAGTCAGT
+TGGAATATAGTTGCCAAATCTAGTAGGGAAGTCTGCTAATGCTGTTTGACTAGAAATAAA
+CCTGTGTTCAATTGCTGGACCATAAACTAGATATGGCTTAATAGATGAACCAGGTGAACG
+ATAAGTATCAAAGGCGTGATTAATTTGAGAGTTCTTAAAGTCAACTCCGCCGCTAAAAGC
+TAATACCTTGCCAGTTGCATTATCAATTACAACACTACCGTTTTCCACATGCTCGGTAGT
+ATTAACCCACTTGTTAGTAGATGAATCAAAATCACGAGAAGTCTTATCTTGACCATATTT
+ATTTTGCTTAACTATGCGTTGCATAGTTTGATAAAGTGGCTGTCTAATCGTGGTCTTAAT
+ATGATAGCCCTTTTGATGAAGCAGTTCAGTTGCACTAGTTAAGTATTGATTATAACGATT
+AGTATCTTGTTTAACATCTGATACCTTTAAACCATCTTGCTCAATTAATTTTTCTGCTAA
+AAGACTAGTACTCTTATTCATTACTAAATTATATAAGTAGCCACTTTGTTTCTTTTGTTT
+AGATGCTTTTTCAGGAGCAAGGAAGTCAGCACGTAAATCATATTTTTTAGCTGCAAGATA
+GTCTTTTTTACTGATATCGCCGTTTCGATACATCCGAAATAGAACAATATCTTTTCTACG
+CATCGCTAAATCAAGGTCTTTTTTAATTTTTCCGTTTAAACGATATGGGGTATAAACAGA
+TGGACTTTGAGGTAAACCAGCAATAAAGGCAGCTTGAGGAAGGTTAAGTTCAGAAATAGA
+CTTACCAAATATCCCTTGAGCTGCAGTTTTAATACCTACGATGTTTTCTCCACGGTTGTT
+TTTACCATAAGGAGCAGCATTTAGATATGAACGGAGAATATCTTCTTTTGAGAAATGCTT
+TTCAATCTTATGAGCATAAAACATTTCGGTAACTTTTCTTCTCCAAGTGGTCTGACTAGT
+TAAAAACTGCATTTTAACTAATTGCTGAGTTAAAGTCGATCCACCAGTTTGTACACCAAC
+ACCAGTTAGCTCAGAAAGAACAGCTCTAACTAGGGATTTAGGTAAAACCCCTTTATGAAT
+ATAGAAATTTTCATCTTCAGTAGCTGTCACAGCATTCTTAACTAAAGGAGTTAGTTCGCT
+TTCACTTGCCTTTTTAGTGACGGTATCTGGACGAACTGTAGCAATTTTTTTATTGCCAGC
+ATAGTAAAGTGTGGCTGAATTTTGTGCATGGTTTATTTGCTGATTTAATTCGCTAATTGT
+TGGAATGGGCTGCTGGCGAACGATGCCAAGAGCATAACCACCACCAAAACCGATTAGGAG
+AAACAAACCAAAAACTGCAATTAAGATCAAATAATGAAAAACACGACGTAAAGTTAAATA
+AACGATGCCACTGTAAAATTTCCATTGGCTTTCGTCTGATTTGCTTTGAAGTGTTTTAAC
+TTCTGGCCCCGCAGTTAGGAACTCTATGATTTTTTCTTTTAAATTTTTCACAGATCAGGA
+TCCTTTGTTAGTTACTTTCCCCCTATTATAGCAAAAAAAGGACTAGCAATGACGCTGTCC
+TTTTTTACGAATTTATTAATATTTTGATTTATTTAGTTAATTCATAGATTGCTTCGGCAT
+AAATAGCAATTGAATTAATTAAATCGTCAACCTTCATGTATTCATTTGGTTGGTGCATAA
+CAAGTGGAGCACCTTCTGGTTGAGCACCAAAGGCTACACCATGTTTGAATAAACGGCCAT
+ATGTTCCGCCACCAATGATAACTTCGTGACCTTTCTTACCAGTTTGCTTTTCATAAACTG
+AAAGCAGGGTCTTAACAATTGGATCGTCTCCAGGAACGTAATGAGGAGCTTCTGCTGAAC
+CATCAATTCTGGCGTCTAAGATATCGCCGAATTTTTCGTTAATATTTTTAACCATTTCTT
+CTGGCTCAATACCTTGTGGGTAGCGAACATTGTTTAATAGGTATGCGTTTTGACCTTCAA
+AGTTAAACATACTTGGTGAACTAGTTAGGTCGCCCATTAAGTCGTCATGATGGAAAATAC
+CTAATTTCTTACCGTTAAAGTCTTTGTGTTCAACAGTTGCAAGGAAGTGTAAGAAATTCT
+TCGCTTGACCGTCAAAGTTAAGGCTATCAAGGAAGAGAGCAAGGTAAGTAGCAGCATTTC
+TACCAGTTTCAGGAGCAGAAGCATGAGCACCATGACCGGTTAAAGTTAATGAAAGACGGC
+CGCTAAGCATTTCTGCCTTTCCTTCAAGCTTATGCTCTTTCAGGAATAAGTTGAACTTTT
+CTTTGATGCCATCGATATCGCCTTCAAGTTGAGCATGAGCTGTTTGAGGGATAACATTAG
+TTGCAATTCCTGATTGGAATGTCCAAAGTTTAACATCGCCTTGGCTTGGGTCATCTTTAA
+AGTCAAGTTTTAAGGTAACAATGCCTTGTTCACCATTGATAATTGGAAATTCTGCGTCAG
+GAGAGAAAGCAACATCTGGAGCTGGTTGATGCTTTAAGTAATAGTCAATTCCAACCCAGT
+TAGTTTCTTCATTAGTTCCAACTACGAAGTCAATTTTCTTTTTAGGTTTAAAGCCATGCT
+CTTTTAAAATCAGCATGCCATAGTAAGCTGCTAAGGATGGGCCTTTATCATCAGCACTAC
+CACGCCCATAAATTTTGCCATCTTTAATAGTCATCTTAAATGGATCAGTTTTCCAGCCTT
+CGCCAGCAGGAACGACATCCATGTGGCCGATAATACCAACGCGTTTGTCGCCAGAACCCA
+TGTTGATTCGACCAGCATAGTTATCAAAGTTTTCAGTATCAAAGCCGTCACGTTTAGCAA
+ATGATAAAAACTTCTTCATAGCCTTCACTGGGCCAGGACCTACAGGATATTCTTTGCTAG
+TATTGTTTAAATCTTCAGAAGAATCAATTGCAATCAATTCTTTTAAATCATTTAAAATAG
+CATCTTTCTTTTCTTGTGCTAATTTTTTATAATTTAGTTCTTCCATAACGTACTCCTTTA
+ATTTTTATCTCTGATTAAATATTACAGCATTTACATCTGAATAAGTCGACCAAAAGCTTT
+TATTTGGGACTTTTTCAACTGGTAAATAAGGAAATAGGGCAACGTTTGTTTGACGAAAAG
+CAGGATCGAGTTTTCGATAATTCTTATAGGCAAATGTGTTTTTATTAAATAAGCCATAAT
+ATAAGACTTTAGACGACTTAACCCAGCCATCATCAGTAAGAAGCCATAAATCTTTAACTC
+CGCCACTTACACCTAGTATTTTATAGTGTTTTCTTGGCATAAGTTGATTCTTTTTACCAG
+ATTGCTTATCAGGTTTATTATAAGTGAAAATTGGATTTTGAGTAGGGTTAATAATACTTA
+AATTCCAATATGGTAAAATCCATTCAGGTTGTAGGTCCAAACTAACAAGGTCAGCGGGAA
+CAAATTCCTTATCGCCAATTTGGTAAAAAGTCTGTCCTGAAGCAATAACAGCTGAAGAAA
+CATGAACTGGGTCTAAAAAATTAAGTTCTTTTGATGTTGTCACCTTTAGATATGGATTCT
+CACTAATTGTAGTAGGTACACGGCCAAAGTAAATTCCGTCCTTGTTAACGACATATTTTT
+TAGTGCCAGTTTTAGCTAATTTGTATTTATAGCCTCTTGCGGGGAAATTAGTGACAACTC
+CATCAACATCATTGTTGATTAACCAATTCCATAACTTAGGCGACTCATTCATTTCGGCCC
+AAACAAATACCTTTTGATGTAGCGCGTGAAGTTGACTAATTAGCTTGGGATTTTGGGTAA
+CTAGATCAGATGAGATATTGATTCCGTTTACGTAACTTAGTACTTCAAAATTAATTCTTT
+GCAAAGAACCAACAATAAAGATTCTTGGAACATCTGGTAACAGTTGACTCATAGTTTTTA
+AACTTGGTGCAGAAAAGCTGTGAATCATTACTCGATCTTGCATATGGTATTTCTTGATAC
+TGGCAGCAAGGAGTTCTTCCATATTTTTAGGACTATTATGCTTAGTTTTTTTTGTTTCAA
+GCAAAAATTTAGTGTTAGGTTTATCTTTGTAGTAATCAAATAATTGATCTAAAGAAATAA
+TTGATTCACCATTAGCTTGTTTTAAGGTGTTTAAATAGGAAAAATTATTTTGTGATACAA
+TAACCGATGATCCAACAACTCTGCTTAGATCGCGGTCATGAGAAACAACTAAGACGTTAT
+CTTTGGAAACATGCAGGTCGAGCTCTACATAGTCCGCGCCATCTGCAAAAGCTGAGTTAT
+CACTTTGAATTGTTTCTTCTGGATATTTACTGGGATTACCGCGGTGACCAATGACTAGGA
+ATCCCGATTCAAAAATAAAAATCAAACTAAAAAAAAGGGCTAGGAAATAAAGCCTGCTTG
+TTTTCATGTGTACACCTCTATTCTTTTTAACAATAGCATGGATGTATACTTTTTTCTATA
+ATTAATATAGTAGTTAATAATCATTTTTAAGAAAGTAGATGCTGCAATATGGCTTATGAG
+CAACTAGATTTAATCGAAGAAGTTACTCGCAATGATGGATCTAAATATTATGAAATTTCA
+AATATTGATCAAAATGGTATCGCTGAATTAGCCGTAGATCGTGGATTGATAAAGAAGGTG
+CGGATACTTCAGCTAAATTTGGCTAGAACAAAAGCACTTCAATTATATGAAGAATATATT
+AATAAAACGTACCAACTAGAGACTTTAACCAATGAGGATGATTGGAAAGATCCGCAGTGG
+GTTGAGTGGGAAAAGCCTAAAGGAAAAGTTTTAGACGCCTTTAATACAGTATTAAAAGCC
+AATCATATTGGTTAGAAGAGAGTAAAGTATGGAAAAATTACGTATTGTTCATACCAATGA
+CCTACATTCTCACTTTGAACAATTTCCTAAAATAAAAAGATATTTACATCAAGCACAAAA
+TGACAAAAGTGTTGATCAAACTTTTACCTTCGATGCTGGAGACTTTATGGATCGTTCTCA
+TCCCTTATCTGATGCAACTGAGGGCCAAGCTAATATTAAGCTGATGAATGAATTTAACTA
+TGATGCGATCACAATTGGTAATAATGAAGGAATCTCTAATTCACATGCAGTTTTAGAAAA
+ATTATTTGATCATGCGAATTTTCCAGTTATTTTAGCTAACTTACGTGAAGAAGATGAAAG
+TATGCCTAAATGGTGTACTTCATATAAGATTTTTGAAACTAAGAAGAAAACGAGAATTGC
+AGTTGTTGGCTTAACTGCTGCATATCCTATGACCTATGGTCCTAACCACTGGCATGTGAA
+GTTGATTTCTGATACTTTAGATAAGTTACTTCCTACAATTAACGGGCAATATGATATGTT
+AATTATCGTTAGTCATATTGGCTTAAGAATGGATCGGTATATTGCACATCATTATCCAGA
+AGTGGATTTGATTGTTGGTGGGCATAGTCATGATTATTTACCAAAGGGCGAGAAAGTAAA
+TAAAACATGGATTACCCAAACTGGAAAATGGGGTCAGCATATCGGCGATATTGCGATTCA
+ATTAAATGATGATCACCAGGTAGTGTCAATTGTACCAAATACTGTCAAAACCGCTGATTT
+ACCAAGTTCGGAATCTGATCAAGCTAAAATCGATGCTTGGCGTAAGCAGGGTGAACAAAT
+GCTGCAATCACGTCAAATTGCAAAGTTACCTGCTAAATTTAACGATGATAAAATGGCAGC
+AATTCAAGTTTCTCTAGATGCAATTAGTGATTTTGCTGGAACTGATATTGCGGTTTTAAA
+TAGTGGCTTATTTTTGACGCCATTTCATCAGGGAATTTTAACAGAAGCTGATTTACAAGC
+TGCTTTACCTCACCCAATGCATGTAGTGCAAACTAAATTATTTGGAAGTGATGTTTGGCG
+CATGGTAATGGAGATGGAAAAGAACCGTCATTTTCTAAGCAAGTTTGCCCTCAAAGGAAT
+GAGTTTTAGAGGGAAAATTTTTGGCGATCTTGTTTATAAAGGCATTCAGGTTGATCATGC
+AAGTAGAACAGTCTACATTAACGGAAAAGAGATTGATCCTGAAAAAGAGTATACAATTGC
+CTTGCTTGATCATTATGTTTTAATTCCATTTTTCCCTACCATTTCAATTATGGGTAAAAA
+CAAGTTTTTATTCCCTGATTATTTACGAACTGTAATTGGAAACTACTTAAAAGAGAAATA
+TCCAATAGATAAATAGAAAGAAAAATAATGGAGTATAAAGAAGCAGATAAAGAACAACCG
+CTTTATCATCCTTTGGCTCATGTAATCGTTAATGAAGATAAGATAATGATTAATGGGCGA
+AAGTATGAAATTTTAGCTAATGTAAAAGATGCTCTAGATATTGAAATGCTAAAAGAGAAA
+TATGATCCTTTCCTTGACCAGTACGATTATTTAGTAGGGGACATTTCAAGTGAGCATTTA
+AGATTAAAAGGATTTTACGATGAAAAAGATCGCGTTGCAATTGATAAAAAAGCTAATGCG
+ATTGTGGATTATTTAGAGGAATATTGTAATCCTGGCAGTGCATATTTTGTTTTACGACTA
+GCTCAAGAAAATCAGATTAAAAAGGTTGCATTTGGCAGACAAAATAAGAGAAAAAATATG
+TCTAATAATCGCTATCATTCTAAACGTCCCTACTTTAAAGAAAGACGTGTCCACAAAACA
+AGAATTGGTGGCCATAAGACAGCTGTAAAATTTCAACGTGGAAAAGGAAGTCACAAGAAT
+AAAGGCTTCGTAATTAAGAAAAGAAAGGGCTAATTGTGGAACATAAAGATTATAAATGTT
+ACTTAATTGATTTGGATGGGACTATTTATCGCGGTAGCGATACGATCGAAAGTGGCGTTA
+GATTCATTCATCGTTTGCAAGAGAAAAATATTCCCCACTTATTTTTAACTAATAATTCTA
+CTCGTACGCCGCGAATGGTAGTTGATAAATTGCGCGGACATGGGGTTAACACAGATATCT
+ATCATATTTATACGCCGGTTTTAGCTACGGAGTCTTACTTGCTTGCTCAAAATCCAGATA
+CTGCTAAGATACCAGTTTATATCATTGGACAGACAGGATTAGTGCAAGGTCTGTTAAAAA
+ATGAACGTTTCTACTACGATGATCGAAATCCTAAATATGTTGTAGTTGGAATGGATACGG
+ATTTAACTTATCATAAAATTCGCGTTGCTACTCGCTCAATTAGAAATGGCGCAACTTTTA
+TTGGAACAAATGCTGATAAAAATTTGCCTTCTGGGGATGAGCTATTGCCTGGTAACGGTG
+CACTATGTACAATGCTAGAAGTAGCAACAGGTGTTAAGCCCATTTATATTGGTAAACCTT
+CATCAATTATTGTGGCTAGTGCTTTGAAGATGCTAAATGCTCAAGGCAGGGATGCAATTT
+TGGTTGGGGATAACTATGATACTGATATTATGGCAGGCATTAACTGTAATATTGACTCTT
+TGTTAACTTTGACCGGTGTAACTACTAAGAAGCAATTGGCAGAAAGAGATAAGCAGCCAA
+CTTACGTTGTAGAAAATCTGGATGAGTGGAAACTATGAAGAAGAAACCAATCGTCGCCGT
+TGTTTACAATTGTTTGATGGCTCTTGCTACTGCTACTTTAGGTGCAGTAGTTTTAAGTTG
+GCCATTATTAGCAGTTTTTGTAAAAATTCAAAAAACGAATTTGATCGTAAAGACAACCTT
+AGCAAAACTATACACAACTCTTAGATTATTTATTGTCGCCATTTAATGATAGACTTCAGA
+TGTCAAATTTCCCGACTTCTCCAAGTGCAGCGCGACATTTTTATGAGTGTAAGTTACTAT
+TTGAATTAGCGATAATTGTTTTTGTAGTTGGATTAATTATTCTTATTTTCTTAAAAATGA
+GAAAAAGAATGAATTATATTTATATTTCGAGAACAACAGCGCTAATTTTCATGATTTTGC
+CTGTGATTATCTTACCGTTTGCTTTAATGAATTTTGATGAATTTTTTGTAGCATTTCATC
+ATCTATTGTTCAACAATGGGGATTGGCTATTTAACCCTGCGACAGACCCAATTATTAATG
+TATTAACCGAAGAGTTTTTTGCTGGTTGCTTTGCAACTGGCGGAATAATTTATGAGTTAT
+ATTTTTCTTGTTTTATTTTGTCAAAAAAATAAAGGAGCTTTAACGAAGCTCCTTTTTTAA
+TACTAATTTTTTCTTTAACCATATAATCAAGACTGGTAAAACTGAAATTAAAATGATTGC
+AATCACGATCAATGAGAAATGTTCCTGGACGATTGGAATATTTCCAAAGAAGAATCCTAA
+TGCGGAAAATAAGGTTACCCAGAGAAAACCACCAATGAAGTTATAAATGATGAAAGTTCG
+ATAATGCATCTTACTTGCACCTGATACAAATGGAACGAATGTACGAATAAATGGAATAAA
+TCTTCCGATTACAATTGTAATACCGCCGTGTCGATCGAAGAAGTTTTCAGCGGCTTTTCG
+TTTATCTTGATTAATTAACTTGTTGAACCAACTGTGTTTAGTCCCTTCAGCTTGTGACCA
+ATGTCCGATTTCATAGTTAATCGTATCACCTAAAACAGCAGCTGCTATGAAGATTAAATA
+GCAAACCCAGAAGTGAAGATTATATTTGGGCGTTGCTGCCATAGCACAACATGCAAATAT
+AAGTGAATCTCCAGGTAGAAATGGAAAGATAACCAGACCTGTTTCGATAAAAATAATTGC
+AAATAAGATTAAGTAAGTCCAGTTTCCAAACATATTCACAATGGTGACTAAATGGTCATC
+AATATGAAGAATAAAATCGATAAGTCCCATAAATAAAAATAGATTCCTTTCACAAATTAA
+ATACTGGTAGAATGAAAAGTCATTGTTTTTTCTGGAAATAGGTCTTGCATAATGTTGCTA
+ATTGCAATTTGTGCCTCGCCAAATCCTAAAGCAATCATTGGCACTCTTCCAGGATAAGTA
+ATAGCATCGCCAATTGCATATACATGAGGAAGGTTGGTATGCATTTTTTGAGAAACAGCG
+ATTAGATTATGGTCTAATTTGATCCCCCATTTACGTAATTGTCGATTATCGCTCTTGAAG
+CCATATGCAACTAGGATTTCATCAACATTTTTAGTAACAAAATCTTGACTTGCACCAACT
+TTATGCAAAACTAATTCCATTCTATTATTGTTTAACTGCAGATCTTTTGGAAGATAAGGA
+GTTAAAAGTTCAACATTTTTTAAACTTTTAAGCTTATTGACGGAGCTTTCAAGACCGCGA
+AATTCATTTCTCCGGTGAATTAAGAATACATCTGATGTGTTTGCTAATTCTAGTGCCCAG
+TCAAGTGCAGAATCTCCACCTCCAAGAATGGCTACTTTTTTGTTAGCAAAGATTTCAGGA
+TGCTGCATTGAGTAATGGATATGTTGGTTTACGTCTAAAGTAGTTGATAAAGGAAGAGTT
+TTGGGCTTAAACGCGCCAAGTCCCGTAGCAATTAATAAACTTTTTACTTCATATTTTTTG
+TCAACTAGGATATTTTCATTTTCTAAAAAAGAAATCTCTTTTACTTTATGAGAAAGAATG
+AATTTAGTATTGATGTTTTGCTCAAGTAGCTGAGAAACTAGCTTTTTACCTTTAATAGAA
+GGAAAAGCGGGAATATCCTTAATATTTTTTTGTGGATAAAGCATATTAATTTGACCGCCA
+ATTTCGTCTAATGCATCAAAAGAAATTGTCTTTAGTCCATGTAAATTAGCAAAAGAGGCT
+GCAAAAAGTCCAATAGGACCTGCACCAATAATAGCTAAATCATATTTTTCCATCTTTATA
+AGAAATCCTCCATAAAAATTAAGCATAGAAGTCATGTCTTTAGCGTTAATTAAAAAGACA
+GTTATAATTAATATTAGTAAGGGATGAGATAGTATGCAAGTTAAAATTGGCGATATAGTT
+CATGGAAAAATTAGTGGGATACAACAATATGGGATTTTTGTAAGGCTAGATAGCAAAGTA
+GAAGGCTTGATCCATATCTCTGAAATACATGGTGGATATGTTAAAGATATCGGAAGAGAG
+TATCAAGTTGGTGAAACAATAAAGGTACAAGTAATTGATATAGATCCATATTCTAATCAG
+ATTAGTTTATCTAGAAGGGCAGTCCTTCCTGAAGTAAAAGAAGCAAGAAAAAAGCGAGTC
+CATTTTTGGACTTCAAAACGAGTTAAGAAAGGTTTTACTCCTTTAAAAGAAGTATTGAAT
+ACTCAAATTAAAGAAGCAAAAAGTAGATATTCTAAATAAAGAGTAAATAAACGTGTTAAG
+GAGTAGTGCTTAACACAGTTTTTTTATATCCGAATTTT
+>NODE_6_length_39999_cov_63.2183_ID_11
+GGAGGTCACTGAGCTGGGGACGTTTTCCGTCAATACCCTCACGACTTTCCACACCACGGT
+TCAGCTGGCTCAGTGCGATGATGGGGATGTTCAGTTCTTTGGCTAACCCCTTCAGTGAAC
+GTGAAATGGTACTGACCTCTTCCTGACGGCTACCGAATGACATTCCGCTGGCATTCATTA
+ACTGAAGGTAGTCAATGATAATGATTTTTACTCCATGCTCGCGTACAAGCCGTCGTGCTT
+TGGTGCGTAATTCAAAGACGGACAAGGATGGTGTGTCATCCACATACATCGGAGCATCGT
+ATAATTCTTTTATTTTATAATCCAATTGTCCCCATTCATACGGAGCCAACTGACCACTCT
+TGATTTTCTCACCCGGAATTTCGCACACGTTGACAATCATACGGTTGACCAACTGTACGT
+TGGACATTTCAAGAGAGAACAAAGCCACAGGGATTTTCGCATTTACCGCCATGTTCTTTG
+CCATGGAAAGCACAAAAGCCGTTTTACCCATAGCGGGGCGGGCGGCAATAATCACCAGGT
+CGGAATTTTGCCAGCCCGAGGTCATTTTGTCCAATGCATGGAAACCGCTTTCCAGACCAC
+TCAGCCCGTCCGTTCGTGCCGCCGCTTTTTGAAGCATCTCATACGCTTCCTGAATGACAG
+GGTTGATTTGCGTATAATCCTTCTTCATGTTCTGTTGCGAGATTTCGAACAGTTTTCCTT
+CCGCTTCCTGCATCAGGTCGTCCACGTCTTGGGTTTCGTCGAAAGCCTTTGTCTGGATGT
+TGCTGGTAAAGGTAATCAGTTCGCGTGCAAGAAACTTCTGCGCGATGATACGTGCGTGAT
+ATTCTATGTGTGCGGAAGAGGCTACCTTGCCGCTTAGCTGTGTTATGTAAAAAGGACCGC
+CTGCATCTTCCAGTTCACCGGTGCTGCGTAATTGTTCGGCCACAGTCAAGATATCGACTG
+GTTGCTGGCGTAAAGCCAAAGAGGTAATAGCCGAATAAATAAGTTGGTGACGGCGTTCAT
+AAAAAGATTCGGGACGAAGAATCTCACTTACTAATGAGTAAGCATCTTTTTCTATCATTA
+AGGCTCCCAATACAGCTTCCTCCAGCTCAGGTGCCTGGGGCTGTAAATGTCCGTATTCGT
+CAACAGGCTTTGCTTTCGAAGTTTTGGGAGTACGTGTCATTTTTCTCGTTTCTGCCATTG
+TCGTCTGTTTAAAGTAGGGCAAAGATAGAACTTTTTGCTGAGTTGGACACTCGTCCATTC
+CCAAAAATAATAAAAGAAATATGAACCTGAATCTACGGAGAAATGAACAATCTGGACAGT
+AAATGGTTTTTTTATATGGTAAAATGAAAAGTTTGTTCTATATTTGGCGCTCTGTCCGGA
+TAAAAGATGGCGTGCATCTTTGTAGAACGGGCAACAATCTAACGAAACACACTAAAAATA
+ACTATTTAAAGAACAGAATATGATTACATTTCCTAATGCAAAGATTAATTTGGGACTTAA
+TATTGTAGAAAAGCGCCCGGATGGATACCACAATCTGGAAACCATATTTTATCCGATAAA
+CCTGCAAGACGCTCTGGAAGTGACGCGGCGGGAAAACAATGACAAAGAATACACTTTACA
+CATAAGCGGATCTCCTTTGGAGGGTGAACCCGAAGATAATCTGGTAGTAAAAGCCTATAA
+GTTATTAAAAAAAGACTATCCCGGACTGTTGCCGGTAGATATACACATGTACAAGCATAT
+ACCGGCGGGTGCCGGACTAGGTGGCGGATCATCAGATGCCGCTTGTATGATAAAGCTTCT
+GAATGATAAATTTTCATTGGGACTCAGTACGGAACGGATGGAGGAATATGCGGTAAAACT
+AGGGGCAGACTGTGCTTTTTTCATTCGGAACAAACCTGTTTTCGCTACCGGAATAGGGAA
+TCTGTTCGAGCCTGTGGAATTGTCATTAAAGGGATACCATATAATTTTGATTAAACCTGA
+TATCTTTGTGTCCACCCGGGATGCGTTTGCCGAAATAAAGCCTGTGCGTCCGGCTGTTTC
+TTTGAAAGAAATTGTAAGGCAACCTATGGAAACATGGAAAAACAGTATGAAGAATGATTT
+TGAAGATAGTGTCTTCAAAAAGTTCCCTGAGATTGCTGCTATCAAAGATGAATTGTATGA
+TTTGGGGGCAGTGTATGCCGCCATGAGTGGCTCGGGGTCTTCCGTCTATGGTATTTTCAA
+AGCACCGATAGAGAATGTGGAAGATAAATTCTGTGGATGCTTTTGCAGACAGAGAGCGTT
+GGAATAGTGTGGCAGATCAGTGGTTAGTGATTAGTGGACTGCGCTGTCATGCCGCAGGTA
+TTAACCACTAACCACTATAGTCTATCTTTTACATAGTGCCTTGAAATCACAATAGGTACA
+TTTTTCTATGATTTCTGTTTGGGTAAATGATTTTTCCGGATTAAATATCTCTTCTAATAA
+TCCTTGAAGTCGTTCACGGTATTCTTTTTCATATTTACTGAAATCTTCCACAGCCTCTTT
+GGGCTTTCGTGGCTCGCCCATTTGTATAACGGGAGAATAGGTTTCTGTAGCGGCCCGATG
+AATATAGAGAAGGGCCGGAGCTATCTTCATCGTTGGTTGCTTGCGGCACATGATGGCGGC
+ATACAGGAACGTCTGGAATACATAGTTGGAACGTTTCTTGTCCGGAATAAACAGAGATTC
+CACATGGGGTGGGGTGTCTGCATCACCGCCTGTCTTGTAGTCCACAATACGGAGTGTGCC
+ATCCTTGCTGTCCATACGGTCAATAATTCCCCCGATACGTGATTTTATGACTCCTTTGGG
+TGTTTGTATGTCGATGGGTTCATCCACTTCCATTTCCGATGCAATAAAAGTGAAGGGAGC
+GTAACGTAAATCATTTTGTAAAAGTTGTTTTAAATATCTTGCAATAACGGCAGAGTTGAT
+AAGTTGTATGCCGTTATATTCCGGTTTCTCGTTTTGCGGAACATTAAAGAATAATTTCTT
+GAATGCTGTATCCACATAATCTTGCAGCTTCACTTCATTGCGTAGCAACGTTTCCAATGC
+TTCCTTATTAATGACTTTGCCATGAGTGGTCAGGTCTTTATAAATATGTTCGGCTGCATA
+ATGGAAAATACTTCCGAATGTGGCAGAATCTATTTCCGCACTCACTTCATCGGGGGCGGA
+GAGGCCGGCTACATACCTATAATAAAATTTTAAAGGACAATCCAGGTAATAATTCAAGGC
+TGATGGAGAAAATTTTGCTTTGGGATTGGCACGGACATCAAACAGGCTTTGCATCCGGCG
+CATGACATCCGGGGTCTTTTCTACAGTGATAGGCGAGGTGCCTTGGGGGGACTGTCCGGC
+CTCCAGAAACTGGCGTGTGATGGGGTGAGGCCATTCAATAAGGAATTGCAGCATGAAACG
+GCTCCATTCGCCGCGGTTCAGTCCGTCCGAACTGGTATTGTACATCAAGGTAATCCTTTC
+TGCCCGTTGCAGCAGACGATAGAAATAGTATGCATATACGGCAATCTTATGCTCTATAGT
+AGTCATTCCGAAAGCTTTGCGCAGGTTGTAAGGAATAAAGGAAGAGTCTCCTCCCGATTT
+GGGAAGCTGCCCTTCGTTGACCGATAGTAATACCAAGTGGCGGAAATCCAGGTTACGTGT
+TTCCAATACCCCCATGACCTGCATACCAATGGCCGGTTCGCCATGGAATGGAATATTGGT
+CGCTGACAAGACCTTGACCAGCAATCGCCGGAATGTTTCGCTCTGTACGGTTAATTCATC
+TTCTTCTATCAGTGTGCGGAACCGGTTGATGGTGGTATAGGCTTTGAAAAGCGACTCCCG
+GTAAAGTTGGTTGAATGCATCTGTGTCCTCGGTACCGGAAGTGTTTGCCTGGTAAATGCC
+TGCCACTTGCTGCAAAGTTTCGGACAGGCGTATGCACAGATTCAGGTTTCCGGAAAGCGG
+AGTGAAAAGCCGGGTAAGGAATTCATCTTTACCCAATTCGCCGGGTAACGGATAGAAACG
+GTTGTTCCGGGTCAGTTCTTTTTCCAACAATTCGGCTTGACCGGTGAGTTGCCGGGTATA
+GGGGTGTTTTAACAGTGTAACAACCGATTGAAACGTGTAGCGGCCGCTTTTGAAATTAAA
+TCCGTGGGTATGCAATTCCAGTAAGGCGATGAGGAAACTATATACAGGAGTTTGCGATAA
+CGGAAATCCCATGGTGATATTGACATGTTTTACTTCTGCCGGCAATGAATGGAGGACCGG
+CTGAAGCAATGCTTCGTTACACAATACGACTGCGGTTTCCTTTTCCGGTGTAGTCAGATT
+GTTTCGTATCCATTGAGGCAGGTAACGGGCTTGTGCATTTTCAGTAGAAGATGCGATGTA
+GTGTACCTCTTTAGGTTTCGAGAGATTTTTGAATAACTCACCGGACAAAGGAGAAGGAAA
+GTCGCGTAAGTTCCGGCGGATAAACTCTCCGGCTTCATGGGTGACGGCTTGTCTGTTTTC
+CTTCATATAAAATTCGTCGTAATCCCAATAAAAAACAGCTTTCCCGGCATCTTTCAATTG
+GGTGAACAACGTATGTTCTACTTTGTTCAGTACATTAAATCCTACAAAAACATATTTCTC
+GTATGGAAGTTTGTCCACATTCAGATGCTCTATGACGTGGCGGTACATCATTCCTTCGTA
+GGCAATGTTTTGAGAAGCTAAGGATTCACGGAACCCTTTGTAGATGTTTCCCAATACGTC
+CCATAAAGAGATAAACCGTTCTTTCAGCGCTGTTCTCCGTTCGATGGAGAAGTTCTGGAA
+GAACTGCCGGATAGCTTCTTCCTGCTCATCGTCAATGAAGGTGTAGTCGTCCATTATGTT
+GCGCAGATCCTGTAAATTGGAAAACAGTTTGTCGGTATCCACTTTATTTTTGTCGGCATC
+GTCAAAATCACTGATCAGCATTTCTCCCCAAAAATAGAAATCATCCAGTGTTTCCGTACT
+TTGAGTTTCCCGTCGGAATATCTTATAAAGTTCGCATACCAGTTTTACCGGATCACCCAC
+TTCCCATGGAGAAAGGCTACGGAACAATTCGCTGATGCTGACGTATGCGGGCGACCAAAT
+AGGTGAATCCGACTCTTGGGCGAGATACTCATTAAAGAAAAGTCCGGCACGTTTGTTAGG
+AAAAACCACGGCTGTATGTGCCAGGTTTCCTTCCGTATGTTTATATAAATCGGCTGCTAC
+CAGTTTCAAAAAGCTTTCCATTATTCTATTTCCTCCAGTTCGTTGTTAAATACATACCAT
+AAATAGCCACGGATATGCTCATATCCCATATCCGATAATAAATCCATATATTCTTTCACC
+TGCTTGTTGTAAGCTTTCCGCTTTTTACCGAATTTAAAGTCCACCACAATCACCTCTCCG
+TCTTTCATCATCACGCGGTCCGGACGGCGGGTTTGCAGCACTCCTTTTTCCCGATAAATA
+ATGGCACACTCATTGTATAGTTCCCAGCGGCCCGAATACCATTCTTTGACCAGCGGATGC
+TTCAAAGCCCATTCGGTGAGTTTTCGTATTTGTTCTTCCTGTTGTGCCGACTCTATGATT
+CCTTCGAAACGCAGGCGTTCTATGGCGGGAGGCACATCGTCCGTGGTACGGATTACGGAG
+AACAGATTATGCAACAACTGTCCTTGCCGGATGTATTTGTCTTCCGCTTCCTCTTCTCCC
+CGGATAAATTCGGCAGAACGGTTGGACTGCTTGAATTCGATGTTGGTTTCCAGCGTTTCC
+AGATGGATAGGCAAACGTCGGGCTACAGTCAGCAGCTTGTTGCCGGATACTTGTTTTTCC
+TCTTCGTGAGATGAGAGATAGAGCGTTCCCAGTTCGTATATTTCTTCTCCGGTGGCATAG
+CTCTTTCCGGTCATGTCGGATAAGGCACTTTCCAACAATTCGGATACCGTTCCTTTCTGT
+TCCGCCTTTCCATATATAATCAAGTTCTTTTTGGCACGGGTAAATGCCACATAAAGCAGG
+TTCAGATTATCCACCCATAATTGCAAGCGTTCATTCAGGAACTCTTCCCGATAAATGGAT
+TGTTGCATGGCTGTGGAATAGTTGATGGGAACAATGTCAAGATCGCTAAACGGAGCTTGC
+CGGGGAGCACACCATACCAGATGATTGTAAGTCTCATTCTCCATTTTCCAGTCGCAGAAA
+GGTAGCAGTACGGTATGGTATTCCAATCCTTTGGACTTGTGGATGGAGAGAATGCGAATT
+CCTTCCACCTCGCCGGAAGGGATGGTCTTGCTGCCTAGTTTTTCTTCCCAGTAGGTGATA
+AAAGCGGATAATTCGGAAGAATTGCTTTGCAGATATTCCGTCACGGCATCAAAGAAGGCG
+CACAGATAGGCATCCTGTTGTTCGATGCAGGACATCTGGAACAGATTGAAAAGTTTTTCC
+ATCAGCTCATACAGTGGCATGAGGCGAAGTTGCTCCGCTTCTTTTATGAAATCGAATGGC
+AGATAATCATCTATCTCGTTCAGCAATAGAGTGTTGAGGTCTATTCCTTTATGTAATACT
+TCATTCTGATAGGCAGTAGCCAGTTGTGCCTTGGCAATCCGGTTTTCGGGTTGTGACAAG
+TAGCGCAGGCCATCCATTATCATACATACCGCCAGTGAGGCATCCAGTCGGAATGCCTCA
+TCGGATACGATTTTGTAAGAGGTGTTCTTGTCGAAGTAATCGGCTATTAAAGGAATGCTT
+CTGTTCTTGCGCACCAGGATGGCAATATCTTTCAGTTGCACGCCCTGCGCCACAAGCAGC
+TCCACTTCTTCTCCTAGGTGGTGCAGGGTGTTTTCCATATAGGTCATGTCTTCCGTATCC
+GATAGAAATTCCACTTTGACATACCCTTTTCCGGGATCTTTGTATGTTTCCTGACACACG
+TCGTTGTAGGCTTCCTTCAGTTCCTTGCATTCCTTTTTTTGTTCTTCCTTGTAAATGTTG
+TTCAACACCTCGCAGGCGGCTGTAAACACTTCGTTGTTGAAGTGAATGATGTTTGCGGCG
+CTCCGGCGGTTGGTGGTCAGTGTCTTTACTTTGACGGGAAAGGCTTCGATGTTTGTTTTC
+AATCCGTTCAGTATGCCCCAGTCACCGTTTCTCCAGCGGTAGATGGATTGTTTCACGTCT
+CCTACAATCAAGCTGTCTGCTCCCTGAGACAAACCTTCGAGCAGCAACAGACGGAAATTG
+TCCCATTGCATACGCGAAGTGTCCTGAAATTCATCGATCATTACGTTGCGTATGGTTGTT
+CCTATCTTTTCGAATACAAACGAGGAATCTCCTTCTTTTACCAGGTTATGAAGCAACGCG
+TTGGTATCCGACAGCAGGAAGCGGTTGTTTTCATGGTTCAATTCGCGTACCTCTTCGTCT
+ATATTGGCCAGCAGACGGATATTGTTTACGTGGCGCAGGGAGAGTTGGCAGGAATTGGCC
+AGCATATTGTTCCGGCTTCTGTATTTTTCCGATTCATTCAGCAGAGGAATCAGTTCTTTT
+TCTGCCAGACCTTGGATAGCGTTGCGTATGGGGGAGGTTTTTTTCACCCATTCGTCGGGG
+CAGTCCAGACATTTTTCCACTGTTACATTGCGGACACTGTCATCCAGTTTACCCGATTGT
+AATTTATTAAAATAGCTGGCTATACCTCGGGAGCCGTTTTTCAAATCTTCTACTTTCACC
+CCGTTTGTATCCAATATTCCGAAGAATTGGTCGGCAAATCCTTTCATTTGTTCCTGCACC
+TCTTCCAAAATGGCTTGCAGCGTTTCGCGGTAATTCTTGATACAGTCTTTGTCCCGTAAT
+TTTTCCCGTAGTCCGTTTCCTTTTTCTATATATCCTTCATCGAAGATATTTCGTCCGAAA
+TTCTTTATCTCACCGGAAACATTCCACCTCTTGTCATCGGCTATTCTTTCTTCTATGTAT
+TCCAACAGCCAATAGAGTACGGGAGATTGTCGGTCCAGCTTTTCTATCATGGAGTCCACG
+GCATCACTCAGTACCTCCATATTGTTCAGTTCGATATTCAGATTGGCACCCAATTCCAGC
+TCCCGTGCCAAATTGCGCATCACCGACTGGAAGAATGAGTCAATGGTTTCCACCCGGAAG
+CGGCTGTAATCGTGTATCATGTAGTGCAGTGCCGTACCGGCGGCTGTCCTTATGTCTTCT
+TGGGGCCTTTCCAGTTCTTCTGTGATTTTCTGTAAATAGGGATCAGAATCCTTATCCTTT
+ATCCATATTCCGTATAGCTGGCTCAGAATCCGCTCTTTCATTTCGGTAGTGGCCTTGTTG
+GTAAAAGTCACAGCCAGTATATTACGGTATGCCCGTGGGTTCTGTATCAGCAGTTTTATA
+TATTCCACGGCCAGTGTGAATGTTTTTCCCGAACCGGCAGAGGCTTTATAAACTAATAAT
+TCAGGAGAATGTTTCATTTTAAATAATTTGCTAATTTGCTAATGGCTGCGCTGTGTACCG
+GATGGTAATTGGCTGACACATTAGTACATTTTTATTTTTAATTAAAAACCAGCACAAAAA
+CAGTGGCCTGTCCCTTTTCCTTGTAAGGCAGCAGGGTCAGTGTGCCACCGCTCAGTCTCA
+TGATTTGTTTGCTCAGGCTCAGTCCGATGCCGCTTCCTTCCTCTTTGGTCGTGAAGAAAG
+GTACAAAAATTTGTCCGGCTGCATCGGGAGGAATGGCGGGACCGTTGTTGGCTATCTCTA
+TACGGATACTTTCTTGCGGATCACAATAAGCTTTCAAGGTGATCTTTCCGTCGGGAGCAT
+TACCTATGGCTTGAATCGCATTTTTCAGCAGATTCGTAACCACTTGGGCTATCAGGTTCT
+CGTCGGCAAAGACTATCAGGTCTTCCCGGGCTTCGAGGATGGAAAGGGTGATGTTGGGGC
+ATGGATGCTGGTGCTGTGCCAGTCGGATCATCCGTTCCAGGAAAGGACGGACATAGAACA
+GCGATGGCTCAGGTGATGGCAGTCGTGTCAGTTTGCGATAAGACATGACAAAATTTATCA
+ATCCTTTACCTGTAGAGTGAATCGTTTCCAGCCCTTGTTTCATTTCTTCATTTTCTGCTC
+CGGGAAGAGCCAGCAGTGTTTCGCTGAGGGAAGTCACCGGGGTCAGGGAGTTCATAATTT
+CGTGTGTCAGCACGCGGGTAAGGCGTATCCATGAATCTATTTCCCGTTCATCCAATTCCC
+GATTGATATCACTCAAGGCAATAATGCGGAGTTCCTCGTCTTTGATACGGATGCCGGACA
+CCCGTAAGGCAAGATGCACCGTTCCCCGTTCCGTATTGAACTGAATTTGCAGCTTGTCAC
+CCGGAACTGCTTTTTCCAAAGCAGTCATCAGTTCATCCGAGATGCGGGAGAGTTGTTTGA
+CATGAGTCAGAACATCCAGCCCCAACAGATTCATGGCCTCTTTGTTCTTTTGATAAACGG
+AGCCTTTGCTGTTCAGTACCACTATGCCGGTTTCTACAAAGTCCATGATGAGCTCATAAT
+ACTTCTCGCGTTGTGCCGTTTCCTGTTTTACATTGTACAAAATACGTGCGATACGGTTCA
+GCATGACATTGACCATGGAAGAATCGCCAGGGGAGGCATGTTCGTAAAAACGAACAGCGG
+GGTCGTCGTTTTCGATGGCGTCGAGCAGAAAGGCTATCTTCCGGGTATTAAAAGTGTACA
+GGCGGTAAAACCAGCCTATGGAAACGAGGAATGAAGGTACGATTACGCATAGCCACAACC
+AGTTGCGCTGCTGGATTAGTAAGGTGCAGGCAATGGCTAGAATCAGTACGGTAAATAGGC
+GGAAGAAGAATTGTTTCACAGCTTAATTATTTATTATTTCGTTTGAATGTTCCTTTAGTT
+CCTGTTTAAAAATAGATTATTGTTATTTGTTTTGTCATCCTGAACCATCGTGAAGAATGA
+GATGAGATAATAGGTCATAATCCGAATTTTTTCATCTTATTATAAAGCGTCTGCCGGGTA
+ATTCCCAACTGTGCCGCTACAGCCGAGAGGTTTCCGTTGCATTTCTCTATCGCTTTCTGA
+ATCATTTGCAATTCCATCTCCTCCAGAGTTGAGACACTTGTTTCTGTCGCAGGAGCCGCT
+ATTTTTCGGGGAAAATGAAAATGTTCCTCACTCAATATACCATCTTCATTGATAATGACC
+GCTTTCTCTACGGCATGTTCCAGTTCGCGTATGTTTCCATACCACGGATATGTCCGTAAC
+TTTTCTTGCGCACCGGTAGAAAGAAGGATATTTCCTTTGTCATATTGTTTGCAGAACCGG
+TCTATAAAGCGTTCGGCCAAAGGGATAATATCTTCTTTGCGTTCCCGCAGAGGGGGAATC
+TCGATGTGGATGGTATTGATGCGGTAAAGCAAATCTTCGCGGAATTTGCCTTTGGCCACC
+ATCTCTTCCAAATTACAATTGGTGGCGCAAATCAAACGTATGTTGACAGGTATCGGTTCG
+TTGCTTCCTACTCGCACCACGCTCCGGCTCTGAATGGCGGTGAGTAGTTTGGATTGCAGG
+TGATAGGGCAGGTTGCCTATTTCGTCCAGAAACAAAGTCCCTTCATGGGCGGCTTCAAAT
+TTACCTGCACGGTCGGTATGGGCATCGGTAAACGAGCCTTTTTTATGACCGAACAGTTCG
+CTTTCGAACAGGGATTCGGTGATGGCACCCATGTCCACTGTTATCATATCCCGCCGGTAT
+CGGTTGGACAAGGCGTGTATTTCCCGCGCCAGCATTTCTTTTCCTGTGCCGTTCTCTCCT
+GTAATCAGAATATTGGCATCCGTTTGCGCCACTTTCTCTATCAGCGTCCGCAGTTGCTTC
+ATGGCATTGCTTTCTCCCCAATACATAGAAGATACGGTTTTAGGGACTTCTGCCCTCTTC
+TTGTTCTTTGAGGAATTGCGGCAGGCAGACAGCAAGGTTTCTATCAACCGGGTATTGTCC
+CAGGGTTTGACGATGAAGTCTGTCGCCCCTTCCTTGATGCCGCGCACTGCCAAGTCTATG
+TCAGCGTATGCTGTGAAAAGTACTACGGGCAGGGAGGGGTGTATTTTCTTTATCTCGTGT
+AACCAGTACAGACCTTCATTCCCGGTATTCAGTCCGCTGCTGAAATTCATATCCAGCAGC
+ACCACTTGCGCATTTTCTTCACGTAACGCAGCGGGCAGTGTGATGGGTGAGGGCAGTGTG
+ACGATATGTTCGAAATGATTTTTCAGCAATAGCTTTACTGCCGACAGCACTCCTTTGTTA
+TCATCTACCACAATGATGGTTCCTTGTTTGCTCATAAGTCGTTGTAGCTTCTTTTTTCTT
+TAAAGATATCTTTAGTTGTACGTTTCATGCAAAGGTACTATCTCTTCACACACTCTCATT
+TCCATTCCTTTATAGACCACTACTATTTTGTGTAGCTGTGTGGTGCCCACAGCATTCTTC
+ACCCGGTCGGAATCAGCATAACGATTTGCCTGAGCGATCCCTTCCAGCCTCAGTTCTTCC
+ACACGACTTTCAGAATCTTTGTATTTGGCATATTTCAACTCTATGATATAACTGTGCTTC
+ATGTCCGGATAGATTTCCAGCAAAGGACACAGGAAAAGATCAGCGTATCCTTCTTGTGTA
+TCCGCTTCAGAAATAGGGCGGTAGAAGCGGTTTTGCGCTGTCATGGCCAGTGTGAATCCA
+TGTACGAAAAACTCTCCTTTCTGTTTGTCACGTTGTGAAGCGTAACGTTTCAGACAGTCG
+GCTATGTAACCGAAGTAGGCCTGCCAGTTACCATCGTATGCCAAAGCCGAGGCCAGTTCG
+TCTTTCTCATGACTGCTGAAACTAAGGTCGGCCTCATTGTATGTATTCAGCAAATAGGTG
+TATAGTTGCTCTTCCACTACCTGATTGGGAATGGTGAGTTTGTTTTTTCCTTTATGCATT
+CCGCTGATGGTAAGCATACCGAAATAATAGAGCAGACTTATGAAATTGTCCGGATCGACA
+ATATTCGCAGCCGGAAAGCTATCCTTCAGTTCTCCGGTGATATATCCTTGACTTACCAGG
+GTTTGTATGATGGATGCATCATGAGCAAACTCCTTGTCCTTGCGAATCAGCATCCGGAGT
+TTTTCGTAGTCTATGCGTATGTTGCTTTCTATCATTTTCTGTGGCGCTTTGCCGCGCAGA
+ATATAGTTTTTGACAAAATAGAGAACCATGTTGGAATTGTACAGGGTAGTTTCTCCGTAG
+CATTCCGGTGCGAAGCAGTAGTTGTCATACCACGGCTTCATGATATCTATCAGTTGGCCG
+ACGGTATGGTTGAAAGGACTGTTTGTGGAATAATACGTCAGCATCTCACGCACTTCCTTT
+TCTGTGAATCCTGTCATTTCGTTGAACTCTGGTGAGAGGGAGTAATTGGTACCTATATTG
+AATCCGCTGGTGAGATCATCCATGGTTACGGGGCTTACTCCGGTGATGAAGCAACGCTTG
+ATGCAGGAATCTGTTCCGGCTTTCACTTTGTTGAAGAATGCGCGCAGGTAACCCTCTTTG
+TGTGTCTCTTCAGTGTATCGGTGCAGACTTTCGGCATCGGAGAGAATGGCATTGGTAAAG
+TGGTCATACTCATCGATAAAAAGATAAATTTTCTGCTCAGTCTTGTTGCACTCCGTAAAC
+AGATATTCCAATTGTTCTACCGCTCCTGATTTTTCATCCAGCTTCTCTTTGATACCTTGT
+GGGAGATAGTCGGCATAGATATCGCAGAAATAGTCGAACATGGTCTGGCAGTGTGCGTCC
+AGTCCTTGACGGTAGTTGTGCAATTCCCCGCTGATACCGGAAAAATTGAGTTTCAGCACT
+AGATAGCTGTTGCGGTCCGGCGTGGGGTGCTTTCCTATGTAGAGGTCTCCGAACAGGGCG
+TCAAACTTATCGCGGGTGCGTACATCATAATAATGTTGCAGCATGCTCAAGGTCAGACTT
+TTGCCAAATCGCCGGGGACGGATGAAGAAGAAAAACCGGTCCGACTGTTCTATCAGTGGG
+ATGAAGGCGGTTTTGTCCACATAATAATAATTGTCGAAACGGATGTCTGCAAAGTTCATC
+ATACCGTATGGCAATCGTTTCCTGTTTGAAGGTGCATATTCCATTAGTTATATTATTTTT
+TTTATGAATAAACTCTGGTAAAAGAGATATGTATGGCATACAAAGATACTTTCTTTTCCC
+TGCTTCTCCAAAAAACAAAGGTTCTTTCTTTTTGGTAACATGGAGGAAGCTGTCCGATAG
+GTATCCGCCAATCTTTTCTTTCAGAGAAAACTTTTCAATTTCATGAATTGTTCTATTATA
+AAATAGCATTTCAAATGAAAACATTTATATTAAGCATAATTGTAACCATGATTACATCGG
+TAGCTGGTGCACAGCAAAAAAGTTTTTATGACTTTACGGTCAAGACTATTGACGGGAAGG
+ACTTGCCACTTTCCACATTCAAGGGTAAGAAAGTATTGGTAGTCAATGTGGCATCTAAAT
+GCGGTTTCACTCCCCAGTACGCCAAGTTGGAGGAGTTGTATGAGAAATATGGAAAAGATG
+ATTTTGTCGTTATCGGATTTCCTGCCAATAATTTCCTGCATCAGGAACCCGGAACGAATG
+AAGAAATCAAGGAGTTTTGTACGTTGAATTATGGAGTGACTTTTCCTATGATGGCTAAAA
+TATCTGTAAAGGGAAAAGATATAGCTCCCCTCTATCAATGGCTTACGCATAAAAGTGAAA
+ACGGGGTTTCGGATGCTAAGATAGGGTGGAACTTTCATAAGTTTCTGATTGATGAAAATG
+GTAGATGGGTTGCCTCAATCGGCTCTACTACCAGTCCGCTTTCACAGGAAATTGTAGGAT
+GGATTGAAGAATAAAATGACCAGAAGATAAATAATGCCCTATTGTTATTGCACCAGCTTT
+CCGTTTTTCAGTTCCGACATCAGCAGGTCATAGATGTATGCCGGGCTTTCGATATACAGG
+CCGGTGGAGAAGTCTTCCAGTTTGACGAATGTCTCCGAATTGTGGAATGTGGAGATGGCT
+TCCTGCAAATCCATATCATTACGTTCCACCAAGTAACGGACTACATCGGCGGATATTCCT
+TCAAAGAGGAATTTTGCGGTATTCGTGTTCATAGTCGTTTCAGCATTTTAATCGCTGCCT
+CTGAGTGAAAGAAATATTGTGAAGTCACTTTCGAAAATGTCAGTTCGTGCAATAGTTGTT
+CTTCGTTAATAAAATTCTCGGTGTATAAACGTAGCAAGCGCGCAATGGTATCATCGGCAA
+CAGGGCCAATTACGATATCGTAATCGTGGCAAGGCTGAGTAGTGTTTATATCGCGGTTCG
+ACATGACAAAACGTGCCCATTCCCAGTCTGGCTCCTTGAAAACCTTGACTTTCAATTCGC
+TCGACTGCGCTTCTTCGAGGTCAAACTCAAACATAGTCAGAGTGGGGTTTCCGCTGAACA
+TCCGCGCTGTTCTTGCGGCCATCCTTTGGGCCTGTTCCCTAATGTCGGTCAGGTAAAATC
+CTCTGCCGAAATCCTTATAGGGGCGGCATCTGTTGAGGTCGATGCCGTCGATTGCCGTAT
+TTGAACCGTGGTAAAGTATCATCGCAATGTTCCTCCATTGTTTTGGCAGACGATGGTCAG
+GTCATCCACACAGTCGTTAAAAGAAAGCGTGTGTTCCACATCGTAAAATTCGGTGAGAAA
+ATCAATGCCTTTGAAACGTCTGATATAATTGCTTGCCTCCCGGATTGTCAAATCGTGACG
+GCGCGCAAATTCGACAATGACCGTCATCACATAATCGATTAGGTTCTTGTCCGCTTTCTT
+TTTGGACTTGAGCGCCACTATCGGTTCGACACCCAACGCCTCCGCTATGCGGTTGACAGT
+GCCAAAATTAACACACAGACCGTTTTCCACTTTGGAAACCATTGCTTTTTGGACGCCAAT
+CATCACCCCGACTTCTTCTTGTGTCAATCCTTTGTTTTTTCGGCATTGGGCCAAAAGTTC
+TCCTATTTTTTGCAAATTCGTATTCATACCACAAAAATAGATAAAGTTTCTTGTGTAGGA
+AACTTTTTAACTACAAATATATTCTTTAGATAATTATTATCTTTCCAATTAAATGGCAGC
+TCTGCTCTGACACGCAAGAACCCGTGTGCCGGATGATGATTGTTAGGAAAACAGGAGGGA
+AATCAGTTCCTTTGTACATCATAGGTTATGGAACGGTGGTTCGAAAAGAGTTGTCGCTAT
+TTTTTTGCTTATTTATTTGTGGGGATAAATATTTATCCCTATATTGTATTAGTAAAATTA
+AAAATATCATGGAGAATGATTATTAAAACTGAAAGTTATGGATACAATAAAAGACATTTG
+GTTTGATGCTAACCGCATTTATATGAAAACGGATGGTGGAGAAACTTTCAGCCGTCCCTT
+AGAGGCATTCCCTTTGCTGAAGGATGCAAGTGATAGAGAGCGCCTTGATTTCAAGATAGG
+AAAGTTTGGTGACGATGTTCGTTGGGAATCATTGGATGAGGATATTCATATATCCAGTTT
+TTTCGATACAGCGGAGCCGGATTATGAAAATGAGATAGCAATGATATTTAAACGTTTCCC
+TCAACTAAATGTGTCAGAGGTTGCACGTAGTATGGGAATAAACAAGAGTCTTCTTTCCAA
+GTATATCTATGGTATTAAAAAGCCGAGTGATATAAGGAAGACGCAGATTAAAGAGGCTCT
+CCATCTTTGGGGAAAAGAATTACTTGCCGTTTGATTAATCTCTTAATAATAGTTTAGGTG
+TGATTCCATTTGGTTTCACGCCTTTTTTATGTTAATTTTTCCACAATCATAGTTTCAATA
+GAAAGATAATTAAATATAAGGAAGATATGGCTAGAATAAACAAATACGGCTATGTTGCTG
+CGTGACGTTTTTGCATCCGTCAGGGAGATGCGGTGAACAAGCCAAGCTCATACCAAGAAC
+CGGGCAAGCATGTGATGCAGGCAGGGTAGGCGTGTACCGAGTACCAGGTAGCCTTGTTTG
+CTGTATCTTATATCTTACCATCTGGGCGATGATGCGCCCGGAAGAATTTGCATCAAGGTA
+AGTATACCGATAATCTGTTTCTTGTTTGTTTTTTGAGTAATCAAGAAACATCACTAAAAA
+TAGCGGAATATATTTTCGTCCTATTTATTAAATTGCTATCTTTGCCACGTTTTCCACGCC
+GGTACTTCCGCAAGGAAGTTAGGGAGGTGGGAAATATACATATATAGAAAAGACGTTTAC
+TTGACGTTTTGTTCTTGGCTCTACAGAACTTCGCAAATTCTAAAATCCAGCCAAAACAAA
+GCAACAGTAGGTGTCTGCGGGGTATGTTTATATCCTTGGTGCGCCTTTGCCGGTCAAAGG
+TGCATTCAAGTGTCATTATACATATCGGCGTGGGCTTCTGCGTTGCTCGTTCAGACTGGA
+TTGGGCAATGCGAAGGCCTTGTAGGGCGGGACGAGTAACAGGTACAGATTCCCGCGCTTT
+TTTTATATATAGGTATTATAAATTCTGATTTAACACATAAGAACCGTCCGGTTCGGGAAT
+CTGCGGAAGGTCATCGGTTGACCCGACAGGCTGCATCTACATCGTGCGGATTCCCATCCT
+CCATTTGTTGAAATAGCTTTTCTTTGGTCAGCTTAATCACAAGAGGCCGATTCCTCTTGT
+ATTTTACGAAACTTCTCGTAATTGATTGAATTGCAGATGTATATCTGTACTTCAAAGCTC
+CATAACTATGCTTTCAAGTGAAAAAATGCAATGGTTTGCCATGCGTGCCACTTATCGCCG
+GGGGATGCAGATCAAGGCTTTGTTGGATAAAGAAGGAATCAACAATTTCATTCCCATGCG
+TTACGAAGTTCGTATAAGGAACGGGTGCAAGAGGCGTGAGCTGGTTCCCGTTATCAGTGA
+TCTGATATTTGTTCATTCCGTCCAGTCCGAACTTCAGAAGGTGAAGTTCAAACTTCCGTA
+TTTTCAATATATGATTGATATCCGCAACGGGCAGAAAATCATTGTGCCCGATGATCAGAT
+GAGGCAGTTTATCGCTGTGGCTGGAACGTATGACGAGCATCTTATCTTCTTCAGTCCCGA
+TGAGGTGAACCTGCGTAAAGGTACGAAAGTCCGTATTACGGGTGGTGACTTCGAGGGCTA
+CGAGGGGGTGTTTGTAAAGGTGAAAGGTGCGAGAGACCGTCGTGTGGTTATCAGTCTGCA
+AGGGGTGATAGCCATGGCCATGGCGACGCTTTCGCCGGACTTGATAGAAGTGATAGAAGA
+GCCGAAGAAGAAATAACTTCATTTGCTACGTTAAACATTCTTATTCCTTGATTAATGGGG
+AAGTAAACGATCTGATAATATAAATCTTATGTATAATAATGTATAGAACCACATTCATGC
+CGTCAGGCATCCGGCTCCAGCATCTGATTCAGAATCAGTATAAGGAAATTTTAGCCAGGG
+AAAAGAATAATGATAAATTCATTCATCTGTATGACATTGGTGCGTATTGGGTGGCTTTCG
+AGTGTTCCGCCTGTAGGTTGAGCGGTTTGTTTTCTAAAAGTGAGCTGACTTTGTTTCGTG
+TCCCGGATTGTGTGGAATATGTGGTGATGGTTTCTGTTCCTGCCGATGAGGCGGAGGGCT
+GTTTGGGTGAGTACATTATTTTGCACGATGGAATTTACCGGAAAGTGTGGTCGGAGCATG
+TTTTGCCGATGGGGGATTATCGTCATTGGCATGAGATGGCTGTGAGGTCTGTTTTGTTGT
+AAAGAAAAGTATGCGGACTTCGTGGACCAAGTAAGTGGTGTTACTTTGCTTGGGAACATA
+TCTTACTTTGCTTACGAAGATATCTTACTTTTTTCAATGGAATATGGTCATTCGTCATGC
+TCTATAGGGAATACCCTGAAAAATCCTTCAAAAACTTCAGCCTGCTCGCAAACGCCCTAC
+CCGTGGGCATTCCGGCTGAAGGATTGGGCTCAGGAATCCTTCAGCTGGGGGTTGGAATGT
+TTCAGCCGAACTGATCTTCCTCCGATTCTTAGGGAATCGTTTTTCCTGAAGGATATTTTC
+CGGCTGAAACATTTCACAATGCATATCCTTCAGCCGGAATGCCGACAGGCAGGGTGTTTG
+CGGAGTGGCTGAAAGATCTGAAGGAAAAAAAGGCGTTTCGGCATGTAGATACCGTTATGG
+AAAAAACAACAGGTCAAATTTTAAAAAGCTCTTGTTCTTTCAATGAAAACGTCCTGTTCT
+TTTTTTTAAAGACCTTGTTCTTTTCGGAAAAGAACAGGATCTTTTAAGGGTTAGTAACGT
+GTATGCCGGAAGGTTGGTAACGTGCCACCCCACACGTTACTAATGTGTGGGGTGTAAGAT
+TAGTAATGTTGCAGGTGGAAGATTGCATATCTTGCTAGTGATACAATCATAAACGTATGA
+AGTTCCAGTATATAAAAGATAAAGTTAGTGCTTATTTCACTAAGGGGAATGAGCGTAGTG
+TTGCGGTGAAGAAAAATATCGCCGTTTCATTAGTGTTGAAATGTATAAGTATTTTAGTTT
+CCTTGCAGGTCGTTCCATTGACCATCGGTTATGTTAATCCTACGAAGTATGGCATTTGGC
+TGACGTTGAGTTCCATTATTGCCTGGCTGTCTTATTTTGATTTGGGGTTTGCCCACGGAT
+TTCGTAATCGTTTTGCTGAGGCAAAAGCAAAAGGGGATATGAAGTTGGCAAAAGAATATG
+TCAGTACTACATATGCAGTGCTCTTCTTGCTCTTTTCCGTAATTTTATTGATAACCTTGG
+TGGTGAATAATTATTTGGATTGGAGTCGTATTTTAAATATTGATCCTGTTTATAAGGATG
+AGCTGAGTCTGGTTTTCGGTTTGTTGGCATGCTTCTTTTGCCTGAACATTGTGGCAAGTG
+TCTTTACTACCATGCTGACGGCAGATCAAAAGCCTGCTTTAGCTTCGTTGATTCAAACGG
+GTGGACAGGTATTGGCATTTGTCTGTATTTATATATTGACAAAGACGACTTCAGGAAGTT
+TGAGCGCGTTGGCTTTTGTCTTTTCGGGGGTACCTTGTATACTGGTAATCACTATTTCTG
+TTATTATGTTTCATGATAAAAGATACAGTTTAGTAGCTCCTTCATTACTAAGTGTCCGTT
+TAGTGTTGACACGGAATATTTTGGGACTGGGTGGACAATTTTTTGTCATTATGGTTTCTA
+CATTGTTCATTTTTCAATTCGTCAATATCATTTTATCTAGAACACAAGGACCGGAGGTCG
+TAACCCAATACAATATTGCCTATAGGTATTTTAATGTGGTAAATATGATATTTATCATTA
+TCCTTAATATTTTTTGGTCTGCATTTACAGATGCATATATTAAAAAAGATAGTGGATGGA
+TGAAGAGAATCATTAAAAAATTGGATACATTATGGCTTTTATGTATTCCTGTACTAATTT
+TAATGATATTGTGTTCTGAAATTATTTTTCAATGGTGGATTGGTAATTCTGTATCTGTTC
+CTTTTTCATTATCTGTTTGCATAGCTGTATATGTTTTTCTTCAAACAGGAGGTAATATTT
+ATATGTACCTTATTAATGGAACAAGTAAAGTGCGTATACAATTGATTGTCTATTTATTAT
+TTGCTTTAACAGCTATACCGTTGATGACTTTTTTTGCGAAACGTTTTGGAGTGGAAGGTG
+TTTTGATAGTTCCTGCTGTAGTTTTTGGCTTACAAGCTTGTATTGGAAGAATACAGATCT
+TGAAGATTGTAAATGGTACAGCTAAAGGTATTTGGCTGAAGTGATGAGAATAATAATGTT
+TAAAATAAGATTTTCAATGAGACATTGTTTGATTATGACAGCTTATAAGGATGCAGAGAT
+GATAAATTCAATTATAGATGAAACACCTGTAAGTTGGGGAGTCTATATACATATTGATGC
+AAAATCATCACTTTTATCTTCCATGATAAACAATAGAGCAATTGTTATAAAAAAATATCG
+TATATATTGGGGTGGAATAGAACATTTATATGCATTTATAGAGCTCATGAGTATGGCGTT
+AAATAGTGGGGAAAATTATGATTATTATCATTTAATAACAGGTCAGGATTATTATGCTAT
+ACCTCCGCTGCAATTTGATACTATATTAGGTGGTGATGGGATGAATTATCTTGACATATT
+TCCACTGCCAAGACAAGGGTGGTGGGGAGATGGCTTGGATATTTTAAGGTATAGAACATT
+TTCCTCAAGAACAGATATTCGTAAAGGTATATATCGAAAATTGGATTCATTATGGCGTAT
+AACTCAGAAGATGTTAGGTTTGCAGCGATCACTTCCTTCATATTCTATATATGGGGGTAG
+TGTGTATTGTTCGTTGACAAAAAACGCTGTAAACGAGGTCGTTAATGGAGAGACTTCAGA
+AGACTTATTGCAAAGGCTTAAAAATACGACTTGTGGGGAGGAAGTGTATTTCCAAACGAT
+TTTAATGAATTCAAACTTGAGAGATACGATTTTTAATAATCAGTTACGCTATATAGATTG
+GAATGTGAAAAATGCACCAGGAGTATTGATTGACGAGGATTTTGATAAAATTGTTAAGGG
+AAAAGCTCTCTTTTGTCGGAAACTCGATTCAACAGTATCCAAATCACTATTAATTAAACT
+GAAAAAATATATGAGTGATTTTTCCGTTAGATAAAACGATAGGAAACTTAATAGGTATAA
+GCTATTTTCAAGAAAGGTGTTGGTACAATTAGTAATCATTCTTATCTGTATTGGATGCAG
+TATACAGATATTGAGAAATAATGGAGATAAACGGTTGGTTTATTTTTTATGGGGAATAAT
+GTTTTGTAATTATGGCGTAGAAGTAATTCCTCATTTAAGTGTGTTGCGTGTTCTGACCAT
+TGCTTTTTATATATCAGTGTTTATGAGAAAGAGTAACAGGCTTATTTTATTGAATATTCC
+ATTAAAAAGACAATTCATTCTACTTTTTATTGCATATTTATGTACTGGGCTATTTGATGA
+TAGAGGGTGTAGTGTAGGATTGTATAAAGCCATTTTGGAGTATATGGAAACTTTTGGATT
+TATATTGTTAGGATATATAAGTTTTTATCATACAAACGATTTACATAAATTGCTGCATGC
+AATATTACAGATAGCTTTATGTGTATCTATTTATTCGATAATTACATATTTGATAGGAGC
+GGATATTGTAAATTCACAAATACCAGGAACAGATTTTAGTATGAATAGTGGAGCGAGAGT
+CAGAATACCCTCTTTTTATTACAGTTCTCACATAGCAGGAGCTGCTATATCATCAATGTT
+GATTATAATTATTTCTCCTGAAAATAACAAAAATATAAAACATAGATTATTACTTGCATT
+TTTGTTATTTATAGCATTGTTATTTACGGGTTCCAGATCTTCCATTTTAGCTTTATTTGT
+AGGTTTGATATTTGTATATTATTATTTTTATTCTTCAAAAGTGCAATCACACAAAGTATT
+ATTACTTGTTCTAGGATTGGGTGTTGTTGGGGTGGTGGCATCTTTTATAAGCAGGATTCC
+TTTTCTTTCTGATATGTTTGAGGAGGGAGGGGGAGATACTGGCGGAAGTAATATTTTTAT
+GAGATTGCAACAATTAGTATATAGCTATGAACTTTTCTTACAATCTCCATATTTTGGAAA
+TGGCTTTAAATATTTTTGGGAAGTTGTAAAAGTTGATGATAGCTTTTTAAGTAGTATGCT
+TTTGGGAGCGGAAAGTTATGTATTTGTTTTATTGATAGAGAGAGGACTAATACAAATTGT
+TACTATCGTTTATTTCTTCTTCTCATTAATAAAAATTTTCATGCAATATAAAGACAAAAT
+CTTTATCATAACGTGCATGGGTTTAACATGGGCTTTCCTTTTTAATTCAATAGTTACCGG
+AAATGGAGATAAATGGTCGTATATGATGATATATATAGGCTGTGGCTTATCGGTAATTAG
+AAATTGCAGAAAGAATATATCATGTACTAAAAAACAATTATAAGATAATGTTTTCTATTA
+TTATTCCTCTATATAACAAGGCTGATTATATTGCAGAAACACTGAAGTCAGTTCTGAATC
+AAACATATTGTGATTATGAAGTAATCGTGGTGAATGATTCATCGACAGATAATAGTTTGG
+AAGTGGCTTCTAGTTTTCAGGATGAACGAATTCATATTTATACAAAAGAAAATGAAGGTG
+TATCAGCAGCACGTAACTATGGTATTATGCGTGCTAAATATGATTACATTGCTTTTCTGG
+ATGCAGATGATATTTGGGAATCCGATTATTTGGAATGCCAAAAGAAGTTGATAGAAATCT
+ATCCTAATGCTGGGATTTATTCTACTGCTTTCTACTCTTTGGAAAAGGGAAAACGGAAAC
+TTCGTAATGTCTTGATTAATGAACACACACACTTCCTTGTTCATGACTATTTTAAAGAAT
+CCGTAATGAATGGATTATCCATTTGCTGGACTAGTTCCTTGTGTTTAAAGAAAGAAATTA
+TAGAGCGGATACCAATGTTTCGAGTAGGTATTAAGCGTGGTGAGGATTTGGACCTTTGGC
+TTAGAATAGCGTTGAATTATGATGTAGCCTATTTGAACCTTCCGAAAGTCTTTTATAAAA
+CAGGGTTATCTGATAGTCTTACATCAGATTATTCTAAAAATGGAGAATTTCCTTATTATG
+AGTGGCTTAACTTTACATCGGAAAGTTCTTATTATAGAAAGTATGTGATTTTAGCTATGT
+ATATACATGCAAAAAATGCATTTATACATCATGATTACGATACATGTTTGGCCGAGTTGT
+GGAGTGTTAAAACTATTGCTTGGAGATTCAAATGGGCAAAGCGATTATTATTACTAGTAA
+TTTCATGGATAAAAAGTAAATAATGAATATCATTTATTTTGTTCCCAATATTACCATTGC
+AGGAGGTATATTCCGTATAGTGTCAGATAAGATGAATTATTTGGCGGAAAATATGGAAGG
+ACGGCTTTTTTTGGCATATTATGGTAATGGACAGGAAAAACCTATATATCCTTTGCACCC
+GAACATTCAACTGTTACCTATTGATATAGAGTGGAAGGTAGGCTTTGGAAAGAAAATTAA
+TAGAGTATGGAAAAATATAAGTATTATACGTCACATATTTAAAAAATATAAGATAGATAT
+TGCTGTCAATGCCAATGCTCCTTTATTGATATGGATATTACCATTTATTTGTCGGCGGAT
+AAAGAAGATCCATGAGTTTCATTTTTCTTATAAAGGACAACAGATATTAGATGAGGAAAT
+TTTTAAATCGCGAGGAAAGAAATTTTTAGTTCAATATTTAAGAAAGTGTTGTTTGACAAA
+ATTCGATAAGGTAATTGCATTAACAGAGTCTGACAAGAAAATGTGGAATTTACCGAATAT
+ATTTGTAATACCTAATTTTAGCAATATACAACTACATGAAAGAAATGGTAGAAAAAGCAA
+AGTTGCTATATCAGCAGGTAGATTAGAATCTGTAAAAGGTTATAATCGATTGATTGCAGC
+TTGGGTGATAGTTGCACAAAAGTGTCCGGACTGGCAATTGGAAATTTGGGGTGAAGGAAG
+TCTGCGAGAAAGTCTTCAACGACAAATTGATGCTTTGCATCTTTCATCAGTTGTTCATCT
+GAAAGGTGTTTCACCTAGTATAGGTGAAGTATATTCTCATTCTTCTTTTTTTGTCATGTC
+ATCTTTGTATGAAGGTTTCCCGTTGGTATTGGTGGAGGCGATGAATTGTGGCTTGCCTTG
+TGTTAGTTTTGACATTACTGGAGCAAATAGTATCATAGACAATGGTAAGAATGGATTTTT
+AGTGCCGGATAATGATGTAAATGCCTTGGCGGAAGCTTGTATAAAATTGATAGGAGATAG
+AACGTTGTTGGAAAATATGAGTAAACAAGCTTACATTTCTAGTGCTCGTTTTTCTAAATT
+AAAGGTGATGCAGAAATGGTTGGATTTATTTCATGAGTTGTCGGAGAAATAAATGTTATA
+GTTGAGATTAGATATAGCTTTTATTTTTGTAAAAATGAATTATTAAAGAATGAATTATGC
+TTTTATAGACTCCATGGGGTCATTGACATACAATAATGGTATTAAAATTCAAGCCATAAT
+GTGGAAGAATGGACTTGAAAAATTGGGGCACAACGTTAAATTGGTTAATTTGTGGGAGAA
+TATTGACTTCTCAAGTTATGATGCTGTAATCATCTTTGCTATGGGGGCAAATATTTATAA
+ACTGATAAAAGGTCTTTCTAGGATTAATGAAAATATCATAGTAGCTCCTATTATAGATCC
+TAACAGAAGTGATAGGTTTTATAAATTCTTGTTTAAGTTTTATGGTAGTACAAGATTAGC
+GTTATCCAATCATTACCATGATATGTGGTCTGTAAAGGAAAAGGTAAAGCTATGGCTTGT
+TCGTTCAGAACAAGAAAGACATTATGTGAGTTATTGCCTTGATATACCGAACGATAAAAT
+AGCTAAAGTACCATTGAATTATAGAATTCCTGAGATTGGGCAATTAGGTGAAAAAGAGGA
+TTTCTGTTTACATGTGTCTAGATTAGATGCACCTAATAAAAATGTTCCAAGACTTATTGA
+AGCGGCAAAAAAATATGGTTTTGATTTGAAATTGGCAGGTCATATATCTGGAGAAAAAGA
+AGAGAAAAAAATCATTTCACTTATTGGTAGTACAAAGAATATAGAGTATTTGGGAGAAGT
+GAATGAAGAGGAATTGGTATCACTTTATAAAAGAGCTAAAGTATTTGCTCTTCCTTCTTT
+AAGAGAAGGAGTAGGTATGGCAGCACTTGAGGCGGCTGCTTATGGATGTGAGATAGTTCT
+TACTTGTGTAGGTGCGCCTAAAGAATATTATGAGGGTCGTGCTTTGTTAGTTAATCCGCA
+AAGTATAAATGAAATAGGTGCTGCCATAATAAAAGCTATTAATAAAGGGTATTCACAGCC
+TGAGTTAAAATCTTATATAGAAAAGCGTTATAGTGAGAACGCTTGTTTGAAATTATTAAA
+TGAAAATCTGTTGAAGTTGAATGAGTGTTCACTGATATGAAAACTGTTAAGTGTTTATAT
+AACATTCTTATATCGTTTTAATATTGAATTTATAGTTATGGAAAATAAACTGGTTTCAAT
+AATTATACCTGTCTATAATGTTGAAAAATATATTAAAAAATGCCTTGATACTGTTTTATG
+TCAATCACATCATAATCTTGAAATAATTTTGGTGGATGATGGTTCTTCGGATGCTTCAGG
+AATTATTTGTGATGAGTATGCCCAGAAAGATAAACGTGTAAAGGTGATTCATAAAGAGAA
+TGAAGGTGTAAGTGTAGCACGAAATACAGGCATTGATATAGCTACAGGTGAATACATTTG
+CTTTTCTGATGCTGACGATTATTTGCAATTGGATTATGTTGAATACCTTTTGAAGATCGC
+AAATGAAAATGATGCTGATATAGCAGTAACAACTGATTGGTTTATTACCTTTTTAGGAAA
+AGAATTTCCGGAGGATTTAAGAGATATACCACTAGTTCTGAGTCCTGAGCATGCAGCAGC
+AGCCATTTTATATTATCATATTCCAATAGGATGTAACAGTAAAATCTTTAAGCGAAGTTT
+GTTAAATAATAAGATTAGATTCTATCCTCAGCTATCCGTAGGTGAAGGCTTTAATTTTAA
+TGTAAAAGCTTTTTTATCTGCTAATAAAGTTGCTGTAACCAAAAGGCGAATATATTATTA
+TCGTCGTAATAATCCTGCGAGTTGTATGACAAAGTTTAAATTAGAAAAATGTAATACAGC
+ATTGTATGCCATTCAAATGATTAAGGATAATCTTATGATTAAATCAAATAGTTTAAACAG
+AGCATGTGATTTTGCGGATTGGCATACACATGGTGATATGTATAATTGGATGGTATTAGC
+AAAAGTGAAAGATATGTATCCAGATATGTATATGAGATGCTTCAATAAAGTACGTTCTTA
+TTCATTTAAAGCGATATTTGCTCCAATAAGTAAAAAAGAAAAATTTAGAGCGATACTTCA
+GTTTATACATCCTAGATTGTTGGCATTTGTATTAGAGCTTAGAAGAGCTTATTATCAGCG
+GTAACTATATATTTATCTGAAATAAAGCGATGAAAGTAGCAATTCTCTCCATGCAGCAAA
+TTAAGAACTACGGTTCTTTTCTTCAAGCCTTTTCTTTAAAAAAGAATATTGAGTCATTAG
+GTCATACCTGTGAATTTATAAATATTATTCCCGGAGAACAATTAGAAGGATATAAGACCA
+GTTGTTTTTACAATATTAAATTACTTTTCCAGCGCTTATGGGGATGGGATTTTTACAAAC
+GTTTCCAAACGATATTTGTTTTTCAGAATCGTTTTCGAAAAGAGTTCCTACCTTATTTGG
+GAGTAAAAAAAGGAATAAATACAAAACATTATGATGTAGTGGTTATTGGAAGTGATGAAG
+TATTTAATTGTACTCAAAAGACTTGGTTTGGTTTTTCGTCTCAATTATTTGGGAAAGGAC
+TGAATGCAAGTCGGATCATTACGTATGCAGCATCCTTTGGTGCGACTACTATAGACAAAT
+TACAACTTGTCGGCAAAAAGGAAATTGTCTCAAGTTTATTGCATGATTTAGATGCCATTT
+CTGTGCGTGACGAGAATAGCATGAAAGTTATTGAAGAACTAACCGGTAGAACTCCTTGGC
+TTCATGTTGATCCAGTGTTGATGTTTGATTATAATCAATTTATACCTGATAAATTCAATA
+GGAATGAATATATAATTGTTTATACATATCCGGGAAGAATTACTGATAAAAAGGAAATAA
+GTTCTATCAGAAATTTTGCTAAATCAAAAGAACTGAAGTTGATATCAATAGGACATTATT
+TTTCATGGTGTGATGAAGTTGTTATTCCTACTCCGTTTGAAGTACTAGCTTATTTTAAAG
+GAGCATCTTATATTATTACTGATACATTTCATGGTAGTGTATTCTCTATAAAATTTAATA
+AAGAATTTTGTACTATAGTACGAGATATGAATAGTAATAAATTGGTGTCTTTATTAAAAC
+AGTTTGGACTAGAGAATCGTATAGTTACCGATATGAATAAAATGCAAAAGATTTTGGAAA
+CTCCCATTGATTATGCAGGTGTAAATAAAATAATAATGGAGGAAACAAAACGGTCTATTA
+CTTATTTGACACAAAATATCAGATAATGAACTCTTTGTTAGTTACCTACATCTTGCAAAC
+AGAGAAATGGACGTCTCCCGAACTTTTCGAAACGAAAAACAGAATTTACACCTTTCTCAA
+CCCCGTATCTTACCTCATAGCTTTAGAAAACAAATCTTTATTTGAACAATTCGATGGTAT
+TTTTGCCGATGGCTCTTTACTGGTTTCTGCCATAAGATTAGTATACGGAAAGCGAGTGAC
+CAGACGTAGTTTTGATATGACCTCCCTTGCTCCCGAATTGTTGAATTACCTCATGGAAAG
+CCGTAAAACGCTCTATATCGTAGCCTCGGGTCAAGAACAAGTGGAGTGTTCTGTGAGGAT
+ATTTCAAGAGCAGTATCCGGAGTTACGCATTGCAGGGTTCAGGAACGGATATTTCTCTTC
+GAATGCTGAAATGAATAAGGAAGCTTCTCATATAGTCGAATTAAATCCGGATTTTCTGAT
+AGTAGGTATGGGGGCCTTGATGCAGGAAAAGTTTCTGCTTAAGGTAAAAAAGATGGGTTA
+CCAAGGCATCGGCTTTACGTGTGGTGGCTTTGTTCACCAAACGGCAATGAATAGGATGCA
+CTATTATCCGAACTGGGTTGATAAGATGAATTTGCGTTTCGTTTATAGAATGTATAAGGA
+GAAACATACACGTACAAGATATCTGCAAGCTGCATTCTTGTTTCCGGTACGCTTTATCGG
+GGAAAGAATTTTCGGATGAAAGAGCAGACTTTGCTTATTGCCATGTAAATAATGGAGAAT
+GGCAACAACAGGACGAAGATAGCAGTAGGAATAATTTTTCCGAGTATTTTTAATACATCT
+GTTTTCATGCTGCAAATATAAATTAAAATTCATAGAATAGTGAAATTAAGAACTCTAATA
+TTTCTGGGGGGACTCTTTGGAGGAATGAATGTTATCAAAGGGCAGGCTTTTTATGGTACT
+ACAGGACTACTTCATGCACCTACTGCCGTTATGCAGAAAGATAAAACCGTTATGCTGGGA
+GGAAATATGCTTGATGTAAATATACTTTCCCGATATTGGGTGAGAAGTGAATATCATCCC
+TATACCTATAACTATTATATAAATTGTACTTTGTTTCCTTGGCTGGAAGTAGCATATACT
+TGTACGTTGGTAAAGGGGATACATGGTTCTTCTTATTGGCCTCAGCAAACTTGGGGCAGG
+TTTACCAATCAGGACAGATCGTTTCATTTCCGGTTGAGGGCATGGAAAGAAGGCTGGTGG
+AAGGCTTGGACGCCTCAGGTAGTGATTGGTGCGAATGATCCGGGAAGCCATTCTTCAAAT
+GGAGGTGGAGACATAGATTGGGGGGGCGGTGGTAGCGGAAACCACAATTACTTGACACGT
+TATTATCTGGCGGCAACGAAACATGTTGAATTTAGTGGAATAGGTACAGTGGGGGTTCAT
+GTAGCTTGGGTTATCGGTAAAGCTATGAGTGATGTGCATTATAGCCGTCCTGCTGCAGGG
+GTAAACTTTCATTTTGGCATGAAGGGCGAAGGTTTCTGGCAGAAAGCTCTGAATGGATTT
+AATTTGATGGCGGAAGTGTGTCCCGGACATGCGGAAGATCTGCATACAGCAACTTATACT
+GTGAATGTGGGTGGAACTTATTCAATATGGAAAGACCATATCAATCTTATTGCTGAACTG
+AATGACGGTAAATTTTTTAGCGGAGGTATATTCTTTAAATTACATCTTAAATAACTGACT
+TGATTTCTAGTGGATGAAGCATTATAAGAATAGCCGGAATCACTTGGAAAAAGTAGTTCC
+GGCTATTCTTATATAACGATATTTGTATGTCCTGTTTTTATTATCCTACAATGTATTTAG
+CATTCTTGCCGCTTATTTTACGAATGAATACCACAAGCAGCCACGATACGCCAAATGCCA
+CGATTGCGGCAGCGGGAATTTGTAAAGGCACGGGAACACCGATATTGCGCATCAGGACTA
+CACCCGGACCTGTGAAAAAATAATGTATCATATAGATGCCAAAACCACATACGGTCAAGT
+TTGCCAGCATACGCTGGATCAGTTCTGAGCGTACTTTTACTTTCTTGGCTATGAGGAAGA
+AGGGGATAGTCATCATAATCACATTCAAAGAATTATAGGTGAAGAACAGTTCCAACATTT
+CATCAGTGCATTGTGGTAATGCGGTCATGTGGCGGAAACCGAAGAATGTGACCATGTAAC
+CTGCCAGAAACATGGGGATACAGACTGACAGTGTCTTACTCCATGACCAGTCGTGGTTGC
+GCAGATAGTGTCCCAATAGCAAGTACCCGTTGAATCCGGCAAAATAATAGAGCATATTGA
+ACGAGTTCCACGCACAGCCTCCCCAAATGTATGGGGATACGAACTGATAATAATAAGGTA
+ACAAGCCGGTTATTCCCCATGCGACAAGAAACCATAGTTTGGCTTTCTCCGAGGCCTTTT
+CTACCCATGCGGAGAAAATAGGAAGGTATAGATATAATCCGATAAGCAGATAGATATACC
+ACATATGTACGTCTAATAAAGAGAAATTGAGAGGCATTTCTGCTATATAACCCAATGATA
+CGTTGAGTGACTGACGGGCGGCTTCTTCACCGCTATAAGGGAAAAAGTCAAGGATTATTT
+CAGGATTAAGTCCCAACAATCCTGTAAACCAGGGAAATAAATTATAAATGACACTCCAGA
+TAAGGAACGGCCAGAATACACGGCTGATTCTTTTTTTGTAGAAAGCGGATATTTCGCCAC
+GTACGGGGAGCAGCAATGCTCCTGTAATCATGACAAACAGTGGGACACACGGACGGAGAA
+AGGCTCCGTAGGCGGCTCCCCAGAATTTGATTTCATCAATGTTGGCTGGCGGTTCGCCGG
+GGTAAAAGTTGAACGGGTCTGCACTATGGCAGCAAACTACGGTGAACATGGCTACCAAAC
+GAACGACATCCAGCCATACCACATGTTTTCTTGTGGTGTTCATAGCAATAGGTTGATTCA
+TAATTTAATTTTTGATTTGACAGGCACAAAGGTACGCTTTCTCTGAGGATTATTTCTTGC
+TTTGGAACAAAAAATAAAAAGAACTATCCGCAATCATACTACAAAATGAGAATCCTCCCA
+CTGCAAGAGTCACAATCATTTGTCTTTTGCAGGGGGAGGAATTCTATTTAGGGTTAGAGG
+GTTATTTTAGTCCTCTGTTCTTCAACAAGGGATCAATACCGGGTTCTTTGCCACGGAAAT
+TGACATACATGTCCATCGCATCGTCAATGCAGCCGGGAGTGAGGATATATTTGCGGAACT
+TTCCTGCTACTTCTTGATTAAAGATATCGCCTGTTTCCTTGTATGCCTCGTATGCGTCAC
+AATCCAGCACTTCTGCCCAAATATAACTATAGTAACCGGCAGTATATCCACCACCCATGG
+TGTGGTTGAAATAAGTGGTGCGATAGCGTGACGGAATTTGTTTCAGCAATCCGCGCTTAC
+CTAATGTTTCTGCTTCGAACTGCATAACGTCCATATCATCGGGAATTTCTTTTAATACAT
+GATAATCCATATCCAGCAGGGAAGCAGCTAAATATTCAGCCGTAGCGAAGCCTTGTCCGT
+ATTTGCCACTCTTGTCCATTTTTTCAACCAGTCCGGCAGGAATAACTTCACCTGTCTGAT
+AATGTTTGGCATATACATTCAATACCTCCGGTTCAAAAGCCCAATGCTCATCTATCTGTG
+ACGGCAGTTCTACAAAATCACGCGGAACACTAGCCACACCATAATAATGTACATCTTTGA
+AAAGATTATGTAAAGCGTGTCCGAATTCGTGGAACAAGGTATTCGCTTCGTCTGCACTGA
+GCAAAGCGGGTTGTCCGGCTGCCGGTTTGGTAAAGTTGCATACCACGGTTACTACAGGAG
+CCACTTTCTTGCCGTCCTTGTAGGTCTGTGAACGATAGCTTCCGCACCATGCGCCACCTT
+TCTTGCTGGCACGCGGAAAGAAGTCCATATAGAGTACACCTAGATGAGAACCGTCTTTGT
+CCTTACATTCGAATGCCTGTGCATCGGGATGAGGGAGGGGAAGATTGTCCAGCTGGGTGA
+AAGTGATACCGTACAGTTTGTTGGCAACATAGAACACACCGTCACGTACGTTTTCCAGTT
+TCAGATAAGGACGTACCTGATTTTCATCCAAGTCGAATTTGGCTTTCTTGGCTCGGTCTG
+CATAATAACGCCAGTCCCAACCTTCGGCTGTGAAGGTTTTTCCGTCTTTCTTTATTTCGG
+CATTGATATCTGCCAGTTCTTCTTTGGCTTTGGACAGAGTAGGTGTCCAAATCTGATCTA
+ATAATTTATATACGGCATCCGGTGTTTTTGCCATACGTTCTTCCAGTGCAAAGGAAGCAT
+AGTTTTCATATCCCATCAGCTTGGCTTTTTCCAGACGGGCCTTGAGCAGTTTGCGCACCA
+CTTCCTTGTTGTCGTATTCATTTCCGTTATTTCCTCTGTTAATGTATCCTTTGAATATCT
+TTTCACGCAGGTCTCGGTTATCGGCATATTGCAGAAAAGGCATGACGCTGGGATTATGCA
+GGGTGAAAATCCATTTGCCTTCCATGCCTGCTTCTTTAGCTGTTTCGGCAGCACTGGCAA
+TCAGGTTTTGGGGTAATCCGGCTAAGTCTTCTTCTTTGTCCACGATCAATTGGAAAGCAT
+TGGTTTCCTTTTGCATATTTTGGCCGAAGGTGAGCTGTAACATGGAAATCTCACTATTTA
+ATTCCCGCAGTTTTTTTTGACTGTCGGCATCCAGGTTGGCACCTCCACGTACAAAATCTT
+TATAGGTTTCTTCCAACAACTTCTTTTGCTCTTTGTCCAAATTGCCGGGATTTTCATAGA
+CAGCTTTGATGCGTGCAAAAAGTTTTTCATTTAAGGCGATGTCATCGCTGTGTTTTGATT
+GTAGTGGAGAGAGTTCACGGCTCAGTGCGTCCATTTCATCATTGGTATTGGCGCTTTTCA
+GTCCGTAGAATACGGTGCTGACTTTACGAAGTAACGCTCCGCTTTGATCCAGTGCTGCAA
+TGGTATTCTGGAAAGTGGCGGGTTCGGGGTTGTTCACTATAGCGTCAATCTCTTTCTGTT
+GTTCTTCCATGCCCTGCAAAAAGGCGGGTTTGTAATGTTCCATCTTGATTTGGTCGAAAG
+GAGGAACCTGGAAGGGAGTTGTGTACTCTGAAAGGAATGGATTTCCGGTAGGGGCTGCCT
+GTTTCCCTTGCGAACCGCAACCGCTTAATATGGCAACCGCACAGGCTGCCAAAAGAATGT
+GTTTCATAATAATTTGTTTTATATAGGTGATAATGCAAAGATAGTAAAATAAGGCAAATT
+CCAATAAGTTTGAAGCGTAGAACTATTTGTTTGTTTTCATAGTCTGTCTAATTATCATAC
+ATCATTGTCTAATAATTAGACAGACTGTTTCTTTTTGTTATTTTGCAATGTGTTGTTAAT
+CAGTTATTTGTTTGCGTGGCACGGTTTTGGCATTTATATTATAGAGAACGAATTATAGAA
+ACTTTAGTTTCTTATACACTTTATGGGAAGTAACGTTGTGAAACGGGACTTCTCTCTTTT
+AAAATAATAATAATTAAAAACACGAAATATGAAACAGATTTATTATGTCATTCAGGCTTT
+GATACATGGACGTGGAGCTAATATTATAAAAGTCGTTTCGTTAGGCTTGGGCCTGACTAT
+GAGTATTCTGCTTTTCTCAAGAGTTGTGTATGAGCAGAGTTTTGATACTTGTTTTAAGGA
+TCATGATAAATTATACCAATTGTGGAATATATGGACAGTAAATGGAGAGCCTTTTCCTCC
+GAGTGAGTTCATTATCGGTGCAGCTGCCGGAGGCATACTGGATGCAATGCCGGAAATTGT
+GGAATCGGCGGCAAGTACAGGCTCGTGGCCGGTTTCGGCACCTATTTATAACGGGAGTGT
+CCGCTTTGATGATTTTAAAGTTGCTGCTGATTCATTGTTTTTTCAGACAATGGGTATTGA
+GGTCTTGAGTGGTGATCCGGTACGTGAATTGCAGCAAAAAGATGTAATTTTCCTGAGTAA
+AGATTTGGCGGATAAAATGTTTGGCGGTGAGAACCCGATTGGTAAAATAATTAGTTTCAA
+TAAGGAAATTGAGTTGACAGTCAAAGGAACGTATGCTGCTTTACCTGAGAATTGTACTAT
+GCGACCGAAGGCTGTCATTTCCTTGCCTTCTATCTGGAGCCGCCGGATAGGAAATTATTC
+ATGGAACGGTGGGGACAGCTGGAAGGAATATATCCGGTTGAAGCAGGATATTGATTTGGA
+TGAATTGAACAAGCGTATTGATATGGTAGTACAGCAACATATTCCCAGAAGTGATAAGTT
+GGGAATCACTGTCATGGCAAAACCTGTTCGGGATACGTACCGTGGATATGATGAAGTGAA
+AAGAATGCGTAATATTATGCTTATTTTAGGTATATCTATTTTGTTTATCACGACATTGAA
+TTATGTGTTGATTTCTATTTCTTCATTGAGCCGGCGTGCCAAAAGTATTGGTGTTCATAA
+ATGCAGCGGAGCGGGAACGGGTACTGTTTTTGGTATGTTTATGTGGGAAACCGGTATTAT
+TATTTTGCTTTCATTGTTTTTGATGGTTTTTTTAATGTTTAATTTCCGGGAATTTGTGGA
+AGATACTACAGCTGCTAAACTGGAGTCTCTTTTTGCGGTGGAACGTATTTGGGTGCCTTT
+TGGAGTGACTGCTGTCTTATTCCTCATTGGTGGTGTGCTGCCGGGACGAATTTTTTCAAA
+GATACCGGTCACACAGGTTTTCCGGCGTTATACAGAGGGTAAGAAAGGATGGAAACGTCC
+GTTATTGTTTATCCAATTTGCAGGAGTGGCTTTTATATGTGGATTGATGTGTGTAGTGAT
+GCTCCAGTATCATTATGTTATTAATAAAGATCCGGGTTATAATCCTGAGCGGGTAGTGAT
+TGGCGTTAATAATGCACCGGATGCTAAAGCCCGGCTTGCTGCCCGTCACTTTTATGAGGG
+GCTTCCATACGTGGAAGCATTGACTTCGGCAACTAGCTATCCGTCTAATGGATATAGCGG
+GCAGATGATACCGGATGAGAAAGGAACGAGTCTTTTTTCCAGCCGTTATGATTTTACTCA
+GGAGAATTATGTAGCTTTTATGGGAATGGTCATACAGCAAGGGCGTGTGCCTCGTGAATC
+CGGTGAGGTGGCAGTGAATGAGGAATTTGTACGGAGAATGCATTGGGGAAAAGATGTTTT
+AGGTAAGAGTATACAGACAGAAGAAGGCCGTGTCAAAATAGTAGGTGTGATTAAAGATTT
+TAATATTGGCGGATTCTACTCAGAGCTGAAACCGTTTGTCCTGCATCATCATCCCAAAGA
+TTTGGCTGATCTTGTTTATCTCCGTCTGAAGGAACCCTTTGGTGAGAATCTTCAGAAACT
+GAAGCGTGATGCTGCCGAAGCTTTTCCTAATCAAACAGTCGGCTTTGAAAGCTTGGAACA
+AAAAATGGCGGATAGTTATAATTCCGTTCGTGTATTTCGTAATGCGACTTTATTGGCGGC
+AATTGCCATCTTGTTTATTACTTTGATGGGACTGATAGGCTATATTAATGATGAATTACA
+GCGACGTTCGAAAGAAATTGCTATTCGTAAAGTGAATGGAGCTGAGTCATTTGCGATATT
+GGAAATGTTGGTGCAAGATGTTCTTTGGATTTCTTTCCCGGCTGTAGTCGCAGGTACACT
+AGGGGCATGGTATGTAGGTGGTTTATGGATGGAACAGTTTGCTGTGACTGTAGGTTCGCT
+TGTTCCTTATTATGTATGTGTAGCTATCGTGGTCTTGATATTGATTGTCAGTTGTGTCAT
+TTCCAAAACATGGCGCATTGCCAATGAGAATCCAGTAAAGAGTATTAAATCAGAATAAAG
+ATCAATAGAACAAACAATTAAAATTTATTATTATGATACAGATTGAAAATTTAAGTAAGG
+TATTTCGTACTTCAGAAGTAGAAACAATTGCGTTGAATCATGTAAACATAGAGGTGAAAG
+AAGGAGAGTTTGTAGCTATTATGGGACCATCAGGTTGTGGAAAATCCACCTTATTGAATA
+TCCTTGGTCTGCTGGACAATCCTACTGAAGGCAGTTACAAGTTGCTGGGCAACGAAGTAG
+CCAATCTGAAAGAAAAAGAACGCACCCGCCTGCGTAAAGGTGTAATAGGTTTTGTATTTC
+AAAGCTTTAATCTGATAGACGAACTGAATGTTTTTGAAAATGTGGAATTACCGTTGACTT
+ATCTTGGAATCAAGGCCAGTGAACGTAAGGAGCGTGTTCTGGAAATTTTAAAGCGAATGA
+ACTTGAGTCATCGTGCCAAGCATTTCCCGCAGCAGCTTTCCGGCGGTCAACAACAGCGTG
+TGGCTATTGCCCGTGCTGTGGTTACTAACCCTAAATTGATCCTCGCCGATGAGCCTACCG
+GTAATTTGGACTCAAAGAACGGTGCTGAAGTAATGAATCTATTGACCGAACTTAACAAGG
+AGGGGACTAGTATTGTCATGGTAACTCACTCTCAGCATGATGCCGGATTTGCTCATCGTG
+TCATTCATTTGTTTGACGGTAGTGTAGTGGCGAACATTAAAGAATAATAATGAAAGGGTG
+GTTGTAATGAAACAAATCTATTATGCAATACAATCGACATTACACGGCCGTGGAAGCAAT
+GTGACAAAAATCATATCGCTTTCATTAGGCTTGACTATTGGTGTTCTGCTTTTTTCACAA
+ATAGCATTTGAACTCAATTATGAAAAATGTTACCCTGATGCCGACCGATTGGTGTTGGTA
+CGTGGAGGAGGAGAGAATGTAAAGACTGGAGAGAAAGGAGAAGGATATGATGATAGCTTG
+TTTGCTCCGATGGCAGAAGCATTCCGCAGTGATTTGTCACAATGGATTGAAAATGCTACA
+GTCATTTTCAATTTTGAGACATTAAATGTATTCAAGGATGGTCATAAGCTGAAAGACGTA
+AACTACGCTTATGTAGATACTTGCTATTTCCGTACTTTCGGCATCAAAGTATTGAAAGGG
+AATCCTGAGGAATTGCAAAGGGCAGGGAGCATATTCGTTTCTGAAACTTTTGTTCGTGAT
+GTCTTTGGTGGACAGGACCCTGTGGGACAAAAATTATCTTTGGATAAACAGCATGAACTG
+ACAGTCCGTGGTGTTTATCAGGATACTCCGGAAAATACGGCCTATCATTTTGATTTTGTA
+GCTCCCATTTATGCCGGAGGTGGTTATATAGGGGGTGGAACATGGGGGCGTAATGACATT
+TATTATACTATTCTCCGTTTGCGCGATGGGGTGGACAGGGAAGAAATCAATCGTCAGATA
+TACAAGGCTATGCAAAAATATTATCCTGATTCTGCTGATGATGAATGGAGAAATTTTTAT
+GATGCACAGCCATTGCCCGAAATTCATCTGGATGACTCAAATACCCGCACTCGCCTTTAC
+ATTTATGGTTTTTTGGGCTTTGCCATATTTTTTGTGGCAATCATGAACTATGTATTAGTA
+GCTATTGCTACCATGAGCCGCAGGGCAAAAAGTATAGGTGTGCATAAGTGTAGTGGTGCC
+AGTGCAATCAATATTTTCAGTATGTTCCTTTTTGAGACGGGGATTGTGGTATTGATGTCC
+GTTATAGTGGCCCTCTTTATTATTTTCAATACCAAAGATCTGATAGAAGATTTACTTTCG
+GTGCAGTTATCCTCACTCTTTACATTGGAAACTTTATGGGTTCCGATGCTCATTGTTTTT
+GTACTGTTCATAGTAGCCGGAGTGCTGCCGGGAAGATTGTTTTCACGCATTCCTGTCACT
+CAAGTTTTTCGTCGTTACACAGATGGGAAAAAGGGGTGGAAGCGTTCTCTTTTATTTGTA
+CAATTTATGGGGGTATCTTTTGTGATGGGGATTTTGTTAGTATCTTTGATGCAGTATCAT
+CATCTGATTAATAGTGATATGGGTATCCGTACTCCAGGATTGGTGGAGGCGGAAACATGG
+ATGTCACCCGAAGAAGCAGAGAATATGGTTAACGATCTTCGTCGTCAACCCATGGTGGAA
+AATGCCACCCGTTCTATGCATGGTGTTCTGGGAGAATATTGGACTCGTGGGCTGATTGAT
+AATAGTGGCAAGCGAATAGAAACCTTGATGTATAATCCTTGTGATAAGAATTATGCTGAA
+ACCATGGGGATTACTATTATTGAAGGGAAAGATATGCAGAATGAGGGAGATGTATTGGTC
+AACGAAGAAGTAGTGCGGCTGATGAAATGGACAGATGGGGCAGTAGGCAAACGGTTGAAT
+GATTTTGATAAAGCCGGAACCATTGTTGGTGTATTCCGTAATGTGCGCAATACGTCTTTT
+CTTTATAAGCAGTTTCCCGTGGCTTTGGTTTATAGTCATAATACCAGTCACACTTTTGAT
+GTACGTTTAAAACAGCCATACGATGAGAGTTTGAAAAAGCTGAACGAATACATGGAGCAG
+GTGCATTCCACTAAGGCATTGGAATTTATTCCGATAGATACCATGCTGAAGGAAATCTAT
+CGCAATGTATATCGTTTTCGTAATTCTGTATGGATTACTTCTACTTTTATTTTGCTTATT
+GTTGTTATGGGGTTGATAGGTTACGTGAATGATGAAACACAACGTCGCAGTAAGGAAATA
+GCTATCCGTAAGGTGAATGGTGCTGAAGCTTCGACTATTCTTCGGTTGCTGTCCCGTGAT
+ATATTATATGTTGCTGTCCCATCGGTCTTGATAGGAATTGTAGTATCGTACTTTACAGGA
+AAGGCTTGGTTGGATCAATTTGCCGAAACGATAGATATGAATGCGTTGTATTTTGTCGGA
+ACAGCATTGGTGATTATCGCTCTGATAGTGGTGTGTGTCGTTGTTAGAGCTTGGCGTATT
+GCTAATGAGAATCCGGTAAAGAGTATTAAAATTGAGTAACTAAATAGATAGCGATGAAGC
+AATTATATTATGCAATACAAACGATATTACACGGTCGTGGAAGTAATGTGACGAAAGTCA
+TATCGCTTTCATTGGGGCTGACTGTTGGCATCCTGTTGTTCTCGCAGATTGCATTTGAGT
+TAAGTTATGAAAAATGTTATCCTGAAGCTGGAAATCTAGGAATAGTCCGCGCATATTACC
+ATAATTTGGAAACAGGTGAGTCGATGGGGGACGATGGGGATATCTATGATTATTCCGTTT
+TTGCTCCGATAGCGGCGGCTTTGGCTGAGAATATGCCAATAGAAGTGGAAAAAGCTACTT
+GTATAAATTCTTACACAGCCAACGGTAATTATTATTATGAAAATCAATTGTTGTCGGATG
+ACGAACAGTGTCTTATGGTGGATACTTGTTTTTTCCAAACCTTTGGCATTCCGGTTTTAA
+AGGGAAATCCTAACGATTTGATTAACTCCAATACTTTGTTTGTGTCCGAGAGTTTTGCAC
+GCCGTTTTTTGGGTGATGCAGATCCTATAGGTAAAGTGTTAATGTTGGAGCGGAAAACTG
+AAATGATTGTCCGTGGTGTTTATCGTGATATTCCGGAGAATACCATGTTTAAGGCAGACT
+TTGTAGTAAGTGTACATAAAGAAGGAGGTTATAAGGATGGAGCCGGATGGGGAGGAAATG
+ATATTTTTTATGCAGTGTTCCGGACCGGAGAAGCTTCGGATATAGAGGTGGTAAACGATA
+ACATCCAGCGGATGGTGGAGAAATACATGCCGACTGAACATAACGGTTGGAAACTGGAAC
+TCAGTGTCATTCCATTGGCAACAAAGCATCAGACTTCTTCAGAAACAACAAAGCGTCTAG
+TTATCTATGGCTTTTTGGGTTTCTCTATCTTCTTTGTCGCTATTATGAACTATATGCTTA
+TTGTAATTGCTACTTTGGGACGTCGTGCCAAGAGTGTCGGTGTCCATAAGTGCAATGGTG
+CCAATAATGGGAATATCTTCAGTATGTTTATGATGGAAACGGGCATTATTGTTCTGGTAT
+CCATTCTGGTCTGTGCATTTATCATTTTCAATGCGCGGGATTTGATAGAAGATTTGCTGT
+CGGTGCGACTTGCATCACTCTTTACATGGGGAACTTTGTGGGTACCGCTGCTGGTTGTTG
+TACTTTTATTTTTGTTGGCAGGTGTATTGCCCGGACGTATTTTTTCACATATTCCTGTCA
+CACAGGTATTCCGTCGTTATACTGATGGTAAAAAAGGATGGAAACGGTCACTGTTGTTTA
+TACAGTTTACCGGTGTGTCTTTTGTCTTGGGATTATTACTGGTTACGTTAATGCAGTATA
+GTCATTTGATGAACAGGGATATGGGGATCAATACTGCCGGACTGGTAGAAGCCGAAAGTT
+GGCTGGACATTGAAATTGTTCCTCATATGCGCGATGAGATCCGGCGTCAGCCTATGGTAG
+AGAGCGTGGCTACAGCCAGCCATAGTGTATTGGGCCAATATTGGACAAAAGGATTGATGG
+GCAGTGACGGCAAGCGTATAGGTGTTCTTAATATGAACTATGTGGATTTTAATTATCCGG
+ATGTGGTAGGCATTACGATTATAGAAGGAAAGCCGATGACCCATGCCAAAGATCTGCTGG
+TGAATGAAGAGATAGTCCGGCTTAAGAAATGGACGGATGGAGCCGTAGGAAAACCTTTTG
+ATGAGATTAAGGAAGGAACTATAGTAGGTGTGTTCCGTGATGTGCGCAATCAAAGTTTCT
+ATCAGGCGCAGCAACCCATTGTGCTGATAGGTGGTAATGCGTTTAATCATACCTTCAATG
+TACGGTTGAAAGAACCCTACGATGAAAATTTGAAGCGCCTGAATGAATTCATGGACAAAA
+CTTTTCCACAAGTGGCTTTAACATTCCATACAGTGGATG
+>NODE_13_length_39994_cov_62.9723_ID_25
+GCCGGGCCTGCCACCCGTCGAAAGTCCGGTTCTCCGGGAGAACGGCCTCAGGCCGGGCGC
+GGCACCTTGGCCAGCGCCGGCGCCGGCGCCGGCATCAGCCGGCGCACCAGCCACTTGCGC
+ACCGGCACCACGCCGCGCTCCTGGAACAGCACGCAGAACGCCACCAGCAGGACCAGGAAC
+AGCGGGTAGTAGAGCAGCGACGATGGCAGCGCGGCCGCCGCCTCGGTGCAGGCGCGCCAG
+TCGTCGAGACAACGCCCCGGCACGGCGATAAGGCGCTCGCTACGGGAGAACAGGGTGAAC
+ATCGGCACATGCAGGGCGAACAGCGACAGCGAGGCGGCCCCCAGGCGCGGCGACCAGTGG
+CGGACGAAAGCGCTCTTCGGGTCGGCGGGCAGCGCGCAAAGGCACACCAGCAGCAACTGG
+GCCGGTAGCAGCAGGCCGTTGTGCAGCAGGAAGTACCAATGTTTGGCGCCCTGGGTGAAC
+AGGTAGTCGGCCACCAGGAAGGCCGCCACCACCAGCGCCACCAGCGCGGCCAGCAGGCCG
+CGTCCCGGCACCATGCCACGGTCGCGGTAGCCGCGGAACAACCCGTAGGCCAGGATGCCG
+CCAAGGAATTCCGGCAGGCGCAGCAACGGATTGCGGTGCAGCAGGCCGGTCCAGGGGATC
+CCGTAGCTCTCGCTGGCCACTACCAGCGCCGGCGGGATCAGGTAGACCAGCCAGACCAGC
+GCCAGCACCTTCCACTTGTGCCGGCTGCGCATCAGCCGCGGGGCGACGAAGGGAAACGCC
+AGGTAGAAGAACATCAGCGTCGACAGCGACCACAACGGCGCGTTGAAGGTCAGGTAATAG
+GGATTCCAGGCCTGCAGCAGGAGGATCTGCAGGATGCTGTTGACGAACAGTTCGGTGTTG
+CTCATCCAGTGCAGGAAGAGTTCCGGGTGGGTGCGGCCGAGCACTTCGTTGGTGTCGTAG
+ATGACGAAGCGCGGGGTGGCCTTGTCCAGCTCGGGACCGATTCCCAGGTGGCTGAGGGCC
+AGCAACACCAGGATCGACAGCAGCAGGGAGAACAGGTGCAACGGATAGAGATTGGACAGT
+CGCTTGGTCCAGAAACTGCGGGCGCTTTCGCGCAACCGGCCGCTGCGTGCGTAGACATGG
+GCCAGGAGGAAGCCGGAAAGCACGAAGAAGGTACTGGTGGCGAAGAACCCCAGGCTGGTC
+AGTTCGTCGAGACCGGGAAACTTCTGCTCTTTCGGATAGGTATGCAGGGTGTGGTACACC
+ACCACGTACAGGCCGAGCAGGAAGCGCAACCATTCCAGTCCGATGAAACGTTCCTTGGAG
+TCGGGCGTTGCCACGCATCTCTCCTTTGTCATTGTAATGGGCGGTCCGGGGTAGACCCGC
+AAGCTCCCCGGCAAGTTTCACCGGGCCGGCCAGCGGCTACGAACGGCCGCTCCCTAGCGC
+CGGCGGTCGAGGAAATTCACCACTACCCGGTCAAGCCAACCCCACAGGCGCTGGTGCAGG
+CGCATCCACAGGGGTCGCGCGCGCCACATCGCCAGGGTCACCTCGCGGCTGTCGGCGAAG
+TCCGCCAGCAGGCTCGCCGCCGCCTCATTGGTGAAGTCCGGGTCGAGGGCCTCGAGATTG
+GCGTCGAGGTTGAAGCGTAGATTCCAATGATCGAAGTTGCAGGAGCCGACGCTCACCCAA
+TCGTCGACCATGACCATCTTCAGGTGCAGGAAGCGCGGCTGGTATTCGTGGATGCGCACG
+CCGGCGCGCAGCAGGCGCGGGTAGTAGCGCTGCCCGGCATAGCGCACCGGGGCGTGGTCG
+GTGAGCCGCCCGGCCAGCAGCAGGCGCACCTCCACGCCGCGCTGGGCGGCCTTGCGCAGG
+GCCCGGCGAACCTTCCAGGTCGGCAGGAAGTACGGCGTCGCCAGCCAGATCCGTCGGCGC
+GAGCCGTTCAGCGCGCGGACCAGCGATTGCAGGATGTCGCGGTGCTGGCGGGCGTCGGCG
+TAGGCCACCCGGCCCAACCCACGGGCCGCCCCCGGCTGCGGCGGAAGGCGGGTAAGGGTC
+ATGCCCTCGCGGGGCTTCCAGGCTTTCTCTTCGAGACAGGCCAGCCATTGCCGCTCGAAC
+AGCGCCGCCCAGTCCGCCACCACCGGGCCGTCCATCTCGACCATCACCTCGCGCCAGGCG
+CTGACGTCGCTGACCGGTTCCCAGAATTCGTCGGTGATCCCGGCGCCGCCGACATAACCG
+AGGCGCCCGTCCACCAGCAGCAGCTTGCGATGGTCGCGGTAGAGATTGCCGCCAGTCAGC
+TTCCAGCGCAGCGGGTTGTACAGCCGCAGTTCGCCGCCGGCCTCGCGCAGGCGCTGGATC
+CAGGCGCTGCCCAGGCCGAGGCAGCCGAAGCCGTCGAACAGGCAGCGCACGGCGACGCCC
+CGGCGGCGGGCATCCAGCAGGGCGACGAGAAACAGTTCGGCGCAATGCCCGTCTTCCACC
+AGGTACAGCTCCAGCTCGATGCTCCGCTGCGCCGCCTCGATGGCCAGCAGCATGCGCGGG
+AAGAACCGCACGCCGTCATTGAGCAGGGCGAAGCGGTTGTCGCTGCGCCAGGGAAAGACC
+GGGCCGCTCACCGCGAAGTGAAGATCAGCACGGCGCCGACCGGCACCGAGAGCCCGATGC
+TGCCGGCGCCGGCCAGCTTGCGCAGGGTCTCGATGCCGGGGGCGAGGTCGAAGTCGGCGG
+CGTCCAGCACCAGCGGCGACAGGGTCACCACCTGGAAGCGATGCTCGTCCAGGCGGGTCA
+CCAACAGGTCGCTGGCGTAGCTCTTGCGCTTGCCGTGCAGGCTGACGGTCACCGGCTGGC
+GCATTTCCAGTTGCACGCCGTCGGCCAGCTCGACGATCGGCGCCAGGTCGAGCTGGGCGG
+TGATCTCCGCCTCGGCGAAGCGCTTGGTCTCGAACAGATGCTCGCGGATGCGTTCGTCGC
+GCAGCGGGATGTCGGTGCTCACCGAGTCCAGCTCGACGCGCAGGCGCGCCTGCCCCTTGT
+CGTCGACCTTGCCGTGCATGACCAGGAAGCGGCCGACTTCCGAAAGGGTAGCGTTCTTGG
+TGGAGATGAAACTGAGTCGCGACGACTCGTAGTCCAGGTACCAGGCGGCCTGGACCGGCA
+AGGCCAGGAGGGCCAGGCCGAGGCAGATCAACTTGTGCATGCGGGCTCCCTTTGCGTCCG
+GCGCCACCTTAAACCGGCCGCCTGGGAGCAGGCAAACTCCCGCGTCAGTCGAGCGCGTGC
+TGCAACTGACTGACGGTATCGGCCAGGGTTCCCAGGTGCCGGCGGCGCACCCGTTCGACG
+CAATCCTGGTCGCGCGGCCAGTGCAGCGCCACGCTGCCGAGCAGGCGACCCTGGGCGCGT
+ACCGGCAAGGCCACCGCGCGGATCAGGAACGGCAGGCGCACCGGATACTCCCAGTGTCCC
+TCGGTACGCTCGCCGTAGCCCTGGCCGTGGGCCTGCTCGCGGGTGCGCAACCAGAGGTCC
+TCGTCTACCTGGTGCTGGCGCGCCAGGCGGCGCACCTCGCTGTCTGCCAGTTCGCCCAGG
+CAGGCCTTGCCCATGGCCGAATGGAACAGGCTGGCGTGCTGGCCGACCACCAGCCGGTTG
+GCCGGGTAGCGCTTGCGCAGGACGCCGGGCACCGAGCTTTCCGCCACCAGCAGGCGGTCG
+CCGTCGAGAATCGACAAATCGGCGACCAGCCCGGTGCGCTCGCTCAACTCCACCAGCAGC
+GGCGCGGAACGCTCCACCACCTGGCAACGGAAGCGCTCGGCGGCGTCACCGTAGAGGCGG
+GTGGAACGCAGCCGGTAGCGCCGGTCGGTCAAGCCGCGGTACAGCCAGCCCTGCTCCAGC
+AGGGTATGCAGCAGCCGCGACACCGTGGCCTTGGGCAGTTCGGTCAGGTAATGCAGTTCC
+TCGAGCCCCAGCGCCTGGTGCTGGCCCAGCAGATCGAGGATCGCCAGCGCCCGCTCCACC
+GAACGCACGGTTCCCGCCTCTTCTCTTTCCGGCATGACGACACCTCCACCGTCGACAGAC
+CGTTATGGCAAAGCAAGATGCAGGCCCAGGTCATGTAGGAAGAATCTGCGAATACGCCAG
+CATTGCTCCGCGGCCTAGTCGATGCCCCCTGGAGCCTCGAGCATCGCCGGCGGACGGCGG
+CTGACCCAACGGGTCAGGCCCTCGTGGGCATGGGCCAGTTGCAGCACCGCCAGGTCGGCC
+TGCGCCGGGCCGATTATCTGCAATCCCATCGGCAGGCCCGCCGCGCCGAAGCCGATCGGT
+ACGCTGATCGCCGGCAAACCGGCCAGGGTCGGGCCGATCACCACCTCCATCCAGCGGTGA
+TAGGTGTCCATCGGCCGCCCGGCGACCTGCCGCGGCCACGCCGTTTCTGCATCGAAAGGA
+AACACCTGGGCGCTGGGCAGCAAGAGGAAATCGTAACGTTCGAACAGACGCGCCAGCGCC
+CGATACCAGTCGCTGCGATCCAGCGAGGCGCGATAGACCTCGGTGGCGCCGAGGCCGAGC
+CCGGACTCCACTTCCCACTGCGCCTCCGGCTTGAGCCGGACGCGCCGTGCGGGATCGGCG
+TAAAGCTCGCCAAGCGAGCCCTGCACCAGCCACTGGCGATGGACCAGCCAGGTGCGCCAC
+AGGCGCTCCAGGGGATAGTCCGGCAGGCACGCCTCGACCTCGCAGCCCAGCTCGGCGAAA
+TCGCCCAGCGCGGCTTCGCAAAGCTCCAGCACGCCCTCCTCCATCGGCAGGTAGCCGGCG
+TAGTCACCGAGCCAGCCGAGCCGGGCTCTGCGGAAATCGCGCCCGAGGTCGTCGGCGAAC
+CTGCGCGGATCGTCGCGCAACGACAGCGGACAGCGCGGATCGTAGCCGGCCTGGGTGGCC
+AGCAGCCGGGCCAGGTCCGCCACGCTGCGCCCCATCGGGCCTTCGGTGGCCAGTTGCTGG
+ACGAACAGTTCCGCTTGCGGGCCGTGCGGCACCCGTCCCTGGGACGGGCGGAAGCCGTAG
+ACGTTGTTGTAGGCGGCGGGGTTGCGCAGCGAACCCATCATGTCGCTGCCGTCGGCCACC
+GGCAGCATGCGCAGCGCCAGCGCCACCGCCGCCCCACCGCTGCTGCCGCCGGCGATCCGC
+GCCGGATCGTAGGCATTGCGGGTGGTGCCGAACAGCGGGTTGTAGGTCTGCGAGCCGAGC
+CCGAACTCCGGTACGTTGGTCTTGCCGATGACGATCGCACCGCTGCTCTTCACCCGCTCG
+ACGACGATGGCGTCGTGCTCCGGCACCTGCCCGGCGAACAGCGGCGAACCCAGGGTGGTA
+GGAATGCCGGAGGTGGCGGCGAGGTCCTTGATCGCCTGCGGCATGCCGTGCATCCAGCCC
+AGCCATTCGCCGCGCGCCAGTTGCCGGTCGCGCTCGTCGGCCTGGGCGAGCAGGCGGCTT
+TCCGCCTGCAGCGAGACGATGGCGTTGACCCGCGGGTTGAACCGTTCGATCTGCGCCAGG
+TAGGCCTGCATGACCTCGCGGCAGGACAGTTCGCGTCGGCGGATCGCCGCGGACAGCGGC
+AGCGCGTCAAGCGCGACGATTTCCTCGTGGCCGTCGCTTCGATGGCGGGTGGCGCTCATT
+CACAGACTCCTTGCCGGCTTGCCCAGGGCCGGTTCACGGGGGCGCGGGGCGGGCGTCGCG
+CCCTCCCGCAGATAGAGGGTGGCGAGCAGCCCGAGGAAGGCCGCGCCGAGCACGTAGAAC
+GCCGGCGCCACTGGCGAGCCGCCGACCTCGGTGAGCCAGGTGACGATGAACGGAGCGAAA
+CCGCCGAACAGCATCACCGCCAGGTTATACGCCACCGCCAGGCCGGTGGAACGCACCCGC
+ACCGGAAACTGCTCGGCCACCGCGGTCGGCGCCGGGCCGAAGAAGCCGCCGATCGCCGTG
+CACAGCAACAGTTGCATCAGCAGCAGGCGCCCCAGGCTCGGCGCCGCGGCGACCCAGGCG
+AACAGCGGATAGACCATGAGCATGAAGGCCAGGGTCGCGACCAGCAGCACCGGGCGCCGC
+CCGACCCGGTCGGAGAGTCCCCCAGCCAACGGGATCACCAGGGTCATCAGCGCCACCGCA
+GCCATCTGCACCATGAACACCTCGTCCAGCGGCAGGCCCAACTGCTTGTGGGCGAAGGTC
+GGCATATTCACCAGCACCACGTAGAAGGACACCGTGCCGATCACCGTCAGGCCCATGCTC
+ACCAGCACGCTGCGCCGGTATTCGCGCAGCACGCCGAGCAGCCCCTGGCGCTCGCCGGGC
+TCACGGATGGCTTCGAGGAAGGCCTCGGTCTCGCCCATGTAGCGGCGGATCCACAATCCC
+ACCGGACCGATCAGCAGACCGAACAGGAACGGCACCCGCCAGCCCCAGCTCTCCAGGGAC
+TCGGCGTCCAGGCAATGGGTGACCAGCGCGCCCATCCCCGCACCGGCGAACACCGCCAGG
+CACTGGCCGAACAATTGCCAGGAACCGTAGAGACCGCGCCGGTGCGGCGGCGCGCTTTCC
+ACCAGGAAAGCCGTGGCGCTGGCGTACTCGCCGCCGGTGGCGAAACCCTGCAGCATTCGC
+GCGATCACGATCAGCAACGGTGCGCCGACGCCGATCGCCGCGTAGGTCGGGGCGAAGGCG
+ATCATCGCGATGGACAGCGTCATCAGCAGGATGATCAGTTGCATCGCCGCCTTGCGTCCC
+CTGCGGTCGGCATACAGGCCGAGCAGGACCCCACCGACCGGACGCATGAAGAAACCGACA
+CCGAAGGTGGCCAGGGCCATCAACAGCGAGGTGTACTCGTCGCCGGAAGGGAAGAACAGC
+CTGGCGATCAGGCTGGAAAGGAAGCCGTAGACGATGAAGTCGTACCACTCCAGGGCGTTG
+CCGATCACGGCAGCCGCCACCTGGCGGGTACGCGAGGTACCGCTCGGGCAAGCGTGCATG
+GGAATCTCCTGGTAACCGGGGGAATGCCGGCGCGGCTCAGGCCGCGCCGTTATTGGCGGC
+AGTCAGTCGAAGGCCGGACGCCGCGGGGGCGGCCAGCCAGGTCTCGGCGAGCGCGCCCCA
+ATAGGCCGCGCCCCGGACCAGGATGTCGTCGTTGAAGTCATAGGCCGGGTTGTGCACCAT
+CGGCCGTCCTCTGCCGTTGCCGATGAACAGGTAGCTGCCGGGGCAGCGCTGTAGCATCCA
+GGCGAAGTCCTCGCTGCCCATCAGCTTCGGCGTGTCGCCGTCGACCTGCTCCGCGCCGGC
+CAGCTCGACCCCGACCTGGCGGGCGAACTCGGTTTCCTCGACGCTGTTGACCAGCACCGG
+ATAGGCCGGGTAGTGCTCGATGCTGGCCTGGCACCCATAGCTGGCGGCCTGCAACTCGAT
+GATCTGGCGAACCCGCTGCAGCACCTGCTCGCGCACCTGGCCGTCGAGCGCCCGCAGGCT
+CAGGCGCAGCACGGCGCGCTGGGGTATGACGTTGGCCGCCTCGCCGGCCTGCAATGCGCC
+GACCGTGACCACCGCGGCCTTCTGCGGATCGACGTTGCGCGCCACCACGCTCTGCAGGGC
+CATCACCGCGCTCGACGCGGCGAGCAACGGATCGACGCTCAGGTGCGGCATCGAACCGTG
+TCCACCGACGCCCTCCAGGGTGACGCTCAGCAGGTCCTGGGAAGCCATCATCGGTCCCGC
+GCGGAAGCCCAGGTGCCCGGCCTCCAGTCCCGGCATGTTGTGCATGCCGAACAGCGCATC
+GCAGGGAAAGCGCTCCAGCAGCCCGTCGGCGAGCATCGCCTCGGCGCCGCCCTGGCCTTC
+CTCGGCGGGCTGGAAGATCAGTACCAGGGTGCCGTCGAAACGCCGCGTCGCCGCCAGGTA
+GCGTGCCGCGCCGAGCAGCATCGCGGTGTGTCCGTCGTGGCCGCAGGCGTGCATGCGCCC
+GCCGTGGCAGCTGCTGTAGCCGAGCCCCGTGGCCTCGACGATCGGCAACGCATCCATGTC
+CGCCCGCAGGCCGAGCCGCCGCGTGCCGTCGCCCTGGCGGAGGACGCCGACCACGCCGGT
+GCGGCCGATCCCTTCGTGCACTTCGTAGCCCCAGCCGCGCAGGCATTCGGCGACCAGCGC
+GGCGGTGCGTCGCTCCTCGAAGCCCAGTTCGGGATGGGCGTGGATGTCCTGGCGCAGGCT
+ACGCAGGTCGTCGGCGACCTCCTCGAGCCAGGCCACGATGTGTCGATGTCGAGCCATGCC
+GTCTCTCCTCTGGCCGGATTGCGCTCCGGTCTTGTTGGCGGGAGGCCCGGACGCAAGGCC
+GGCCGGGCGTGGTCACAGCTAAGCGCGGCACGCGGCGAAGGACAACGGAAGGCGGTTCCA
+CTGGGTGGAACCCAAGGCCCGCGCCGCCCTCCGCCGGTACGTCAGAACTGTTCCGGCGGC
+ACTTCGCGGAAGTTCAGCACGGCGAACACCGGTACCTCGGGAGTGATCGAGGGAATATTG
+GCCATCTCCTTCAAGGGCTTGAGCTTCTCTTCCAGGTCGAAGTCGAGCAGCTTCAGCAGC
+ACCGGCTCCAGGGTCGCCACCTGGACCAGCCCTTCGCCCTGGCGGGTGACCAGCACGTCG
+GCCTTCAGGCGGCGCTGCTGGCCGTGCAGGTCGAGGGTGAAGTCGAGCTTCTCGACCCGC
+GACTGGCCGACCCGCAGGTCGTCGAAGCCGGCCATGTCCAGGCGGCTCTCCACGGTGGCC
+TCGGGGAAGCGCGAGGTTTCGAAGAAGTTGTCCTTCATTCGCTCGTCGCGCAGGGCCAGG
+CCGCTGTCCAGGGTGCCCAGCGGCACCACGATGCGCGCGACGCCCTGCTTGTCGATCTGG
+CCGCTGAGACGATCGAAGCGCTGCACCTCGGCCATCTTCGCGCGTTTCACGGAAACGAAG
+CTGATCCGCGAGTAATCCGGCTCCAGTTGCCATTCCGCCGCCGACAGCAGAGGGCTGAGG
+AGCAACAACAGGACACACAATACAACAGGCATTCCACCTCCGGCTTCGGGCCGGCGCCGT
+CCCTCGCCCCGCGCCCCGACATGCGCCGCCGGTCAGTCCGGCAGCCTGTCCGCCTCGGGC
+ATGAGCCGGCATCCCTCGCGCGGGCCCAGCCAGGCGGCCGTCTGCGTACTGCCGAGGCCG
+CGGGCGGTCACCCGGCGGCGGGCTTCGTCGTCGAAGAAGCCGCTGATCGGCACGTACTGT
+TGGGTATAGGCCCGGCAATAGTCCGCGGAGTTCCCCATCACGTAGCGGCAGGAGCAGTAC
+TCCTTGGCCGTATAGGCGCCGATGATGGCGGGAAAGGCCGCCAGGTGGATGCGGTTCTGC
+CAGGCCCACGCGAGGGCGGCGAGCAGCCCCAGGACGAACAGGAAGAGCAAGGGATGGCGA
+CGGATCATGGCCGCGCCTCCCCGGCGAACGCCGCCTGTGCCAGGCGCAGGAATTCGTTGT
+GGCGGAAACGCCCGTCGCGGTCGTCGGCGTAGCGCACGATCACCAGCTTCTCCTCGGGCA
+GCACGTAGAGCGCCTGGCCCCAGTGGCCGAGCGCGGCGAAGGCGGTCTCGGCGACGTCCG
+GCCAGGGCGCCGGCGCGCCTTTCACCGCACGGTTCAACCACCACTGGCCGCCCGGCACCG
+CCTCGCCCTCCTCTTCCGCGCTCGGCCGGTAGCGGGCGAAGGGTGTCAGGTTGAACTCGA
+CCCATGCCAGCGGCAGCAGTTGCCGCTCGCGCCAGCGCCCGTGGCGCTGCATCAGCAGGC
+CGACGCGCGCCAGGTCGCGGGCGCTCATGTAGACGTACGACGAGCCGACGAACGTGCCGG
+CGGCGTCTCGCTCCCATACCGCCGAACGGATGCCCAGCGGCTCGAACAGCGCGCGCCAGG
+GGTACTCGGCATAGTCCGCGCCGAGCATGCCGTGGAGGGCCGCCGCCAGCACGTTGCTGT
+CGCCGCTGGAGTAGCGGAAACGCCGGCCCGGCGGCCGGGCCTGCGGGGTTTCGGCGACGA
+AGCCGGCCATGTCGTCACGCCCACGGGTGTAGAGCATCGCCACCACGGAGGATTTCAATG
+GCGCGAACTCGTAGTCCTCCTGCCAGTCCAGCCCGGAAGACCAGTTCAGCAGGTGGCGCA
+ACGTCACCTCGGGATGACGGGCGAACGGCGGGTAGTAGCGCGCCACCGGGTCGTCGAGCT
+GGAAGCGCCCTTCGCCCTCGGCGACGCCAAGCAGCGTGGCGAGCAGGCTCTTGCTCACCG
+ACCAGGTAAGGTGCGGGGTCTCTGCACGGCTCGGGCCGGCGTAGCGCTCATAGACCAGAC
+GACCGTCGCGGATCACCACTACCGCGTCGGTGCGGATGCCTTTACGACGAACATCGTCGC
+GACGACCGAAGGCATAGCGCTCGAATGCCTCCAGCGCCGGCCCCGCGGGCTGTTGGGCAC
+GGGGCCAGTCGGTGTCGGGCCAGTCTTCGGCCAGGGCAGGGAGGGCGAATACCAGGGCCA
+GCGCGGCGAGGGCGCGGCGGGACAACGGCAAAGCGGGCATCGGCGGGCCCTCTCGACGGT
+CGAGGGGCAACCCTAGCATGGCCTCGATGACGCCAGGAAGCGCGGACTCAGCCTGGCATG
+CGGTAGTCGTCCGGGCCGAGCAGGTCGATGCCGCACTCGAGGTTCTCGATCCAGTAGAGG
+AAGGCGCTGATCATTTCCTTGCCGACGAAGGGCCGCCCGTGTTGCGGCACGATCATCTCC
+ACATCCATGTCCCGGACCATCCGCGCCCACAGGCGGCAGATCTTGTTCGCCGCCATGTAG
+CGGCGATGGAATCCGTCCATGTACTGGATATGCGCGGCGAAATCGCTGACCGGCGCCGCG
+TCGTCCACCAGCGAGGCGCCCATATCGCCCGAGAAAAGGATCTTGCTCACCGGGTCGTAG
+AGCTGGAAGTTGCCCACCGAATGCAGGAAATGCGCGGGGATCGCCTTCAACGAGCAGTCG
+CCGAGAGCGATCGCCTGGCCGCGGTCGGGCAACGGCATGACCCGGTCGTAGGTGTTGATG
+CCATGGCTGACCGCCAGGTAGTTGGCCGTCAGGTGCGGCAGGAAGCGCGCCCACAGCTTG
+GAGCAGATCACCCGGGCGCGGGTGTGCAGCAGCCACTTGTCGAGGGCGGCGATGATGTCC
+GGGTCCTGGTGCGAAGCGAAGATGTAGTCCAGCTCCTGCAGCGGAAAGCGTTTCGACAAT
+TCCAGCGAGAGCGGCGTGTAGGTCAGGTCGCCGCCGGGATCGAGCAGCAGGTACTGGCCG
+TTGTCGACGATCAGGAACTGGTTGGACTGGACCCCTTCGCCGCTGACGAGGTCATCGAAA
+CACAGGCACTGGTGGCTGCCGTTGTCGAACAGCACGATCGGTTCGCGTCGCATGGTCGGT
+GAAATCTACTCTGTGCAGGCGCCGAGGAGCATTCCTCGCCGGATGCTGCGCAGGGTAAGC
+GCCTGCGGCGCGGCGCCTCACTGACCTGGGTCAAGCCCGAGGCGGGTCAAGGCCTTCTCC
+AGGCGAACTTTGCGGGCCCCGTTGGCAATCGCCAGCAAGCCGCGATCGCGTTGCCACAAT
+GCCTCCCAGGTCGAGGCGTTGGCGGCGAAGGCGGCATCCAGTTGCCCCTCCAGCGCCGAG
+AACTGTTCGAACAGCCCAGCCAGTACCGCCTGGGTGCCGACGCAGGCGACCGGATGCCGC
+GCGACCTCGGCGCAGCCGCCGAGGATGCCGGCCAGGCGCAGCAGCAGCGGCGAGGGCCAG
+CCGCATTCATGGCCGACCCCATAGAGCCAGCCGACCAGCGCCGCCAGCACATGGACATCC
+TCCAGCAGGCGGAACGGCCTGACGTAGTCGTCCCAACCATCGCCGGGCAGGCGCTCGCAA
+TGGGCACCGTCGAGCAACAGGCGGGAATGCGGCACATCCGGCATCAGCGGCAGCGCCGGC
+AACGCCTCCAGGCGCGCCCCCGGGGCGCCGGCCAGGACCACCGTCATCGACAGTCGCGGC
+GGCTGCCCCGGCGCCTCGTCGCGGGCGGCCACCAGCCACCAGGAGGCGCTGTCGCCAGCG
+GTGACGAAATCCTTTTGTCCATGCAGGACCAGCCCCTCCAGGCGGGTCTGCAGGTCCGCC
+GGGCGCACGCTGCGCTTCTCGGTCACGCACAGCGCGCCGAGACCTTCCGGCGCCGCCGGC
+CAGAGCGCGCGCAGGGCCGCCTGGTAGCCGGCGAGGAAGGCCAGGCCCGGACTCGCGGCC
+AATCGTCCGCCGAGCACCGCCCGCTCCAGGGTGCCAAGACCGTCGGCGCGCGCCAGGGCG
+GCGGCGTGCCAGTCTTCCAGGGAGCCTTCGGTGGGCAGGCGGTCGAGCGGGCCGAGCAAG
+CGTTGCCAGGACATGGCGGACTCCAGTGTGGAATGTGTCGGAACCGGCATCCTGCCGAGG
+GTGCCAGCGTTGAACAACGGCGCGTTACATCCGGCGACAATGTCATACAAGCATCACGCC
+CCTGTCACAGGGGTGACACCGCGCCTTCCTAGCCTGAGCTTGCACAACAAAGCCGAGCGG
+CCGCAACCCGCGGCGCCGGCCCAAGGAGGCCCAGGCATGACCCAGACCGCCATTACCCGC
+GAACCCGTCGCCGGACGCCGCCTGAAGGCCGAGCGCCTGAACGGCGCCCGCGCCCTGCGC
+GAGGCCCAGGCCCTGCGCTACCGCGTATTCAGCGCCGAGTTCGACGCCAAGCTCGAAGGC
+GCCGAAGACGGCCTCGACCGCGACGACTACGACCGTCACTGCGCGCACATCGGCGTCCGC
+GACCTCGACAGCGGCGCCCTGGTGGCCACCACCCGGCTGCTCGACCATCGCGCCGCCGAA
+CGCCTCGGGCGCTTCTACAGCGAAGAGGAGTTCCACCTCTCCGGCCTCGACGCCCTGCAC
+GGCCCGGTCCTGGAGATCGGCCGCACCTGCGTCGCTCCCGAATACCGCAACGGCGCCACC
+ATCGCGGTACTCTGGGGCGAACTCGCCGAGGTCCTCAACGAGGGCGGCTACCGCTACCTG
+ATGGGCTGCGCCAGCATTCCCATGCGCGACGGCGGTATGCAGGCCAAGGCGGTGATGCAG
+CGGCTGCGCGAACGCTACCTGTGCACCGACTACCTGCAGGCCGAGCCGAAGAACCCGCTG
+CCGCCGCTGGACGTCCCGGAAAACCTCACCGCCGAGCTGCCGCCGCTGCTCAAGGCCTAC
+ATGCGCCTGGGCGCCAAGATCTGCGGCGAGCCCTGCTGGGACCCGGATTTCCAGGTCGCC
+GACGTGTTCATCCTGCTCAAGCGAGACGAACTCTGCCCGCGCTACGCCCGCCACTTCAAG
+GCAGCGGTCTGATGGCGCGGCTGCGCCTGCTGCTGCGCAGCGCCCGCCTGCTCGGGCTGG
+TCGCGCTCGGACTGGGCCTGGCCGCTTGGGTCAGCCTGCGCGAGCGGCTGCCCGGCGCCG
+ACGTCACGCCGTTGCGCCAGCGCCTGACCCGCTGGTGGCTGGCGCGCCTCTGCGCGGCCC
+TGCCCTTCGAGGTCAGGGTCAGCGGCGAAGCGCCCCGGCAACCCATGCTGTGGGTAGCCA
+ACCATGTGTCCTGGACCGATATCCCGCTGCTCGGCGCCCTGGCGCCGCTGACCTTCCTGT
+CCAAGGCCGAGGTGCGTGCCTGGCCGCTGGCCGGCTGGCTGGCGGAAAAGGCCGGCACCC
+TGTTCATCCGCCGCGGCTCGGGCGACAGCCGGCTGATCAACCAGCGCTTGGCCGAACAGC
+TGCACCGCGGACGCAACCTGCTGATCTTCCCGGAAGGCACCACCACCAACGGCGAAAGCC
+TGCGCACCTTCCACGGTCGCCTGATGGCCAGCGCCCTGGAAGCCGGCGTGGCGGTGCAGC
+CGGTGGCGATCAGCTACCGCCGCGACGGCGTGCCCGATGCGCAGGCGCCGTTCATCGGCG
+ACGACGACTTGCTCAGCCACCTCGGCCGCCTGCTGCGCGGCGAGCGCGGCAGCGTGCATA
+TCCAACTGCTGGAACCGATCCCCAGCCAGGGCCTGGACCGCGCCGAACTGGCCCGCCAGG
+CCCAGCAGGCGGTGCGCCTGGCGCTGTTCGGCACTGCCGCCACTACGCAAACCCGGCGCG
+CCGCCTAGTCGCGCTTGGGCGGCACCGCCAGCACGTCGCACGGCAGGTCGCCGAGGGCCG
+CCTCGGCCACGCTGCCGATCAGCGCGCGGCGGAAGCCGGTCAGGCCCTGGGTGCCGAGCA
+CCGTCAACTGCGGCGCCTGGCGGCGTACCTCGGTCATGATCACGTTGATCGGCAAGCCTT
+CGCCGACGCGCAACTGGATGTCCTCGCGGCCCAGCCCCAGGCCGGCGACGTAGTCGCGCA
+GCTCGACGTTGGCCTTGAGTTCCTCCTGGTCGACGTAATGCTCGACGCGGTCTTCCTTGA
+TCCCCGAATAACGCATCATGCCTTTGGCGAACGGCTCGAAGGCATGCAGCGCGGTGAGGC
+TGGCGGCGTCGAGGAAGCCGAGCTGGCCGGCCATCTGCACCGCGCGCGTCGAGGTCGGCG
+AGAAGTCCAGCGCCAGCAGCACCCGGCGGTACTCCTCTTCCGGCGCACCGGCCGCGCGCA
+GCACCGGGATCTTCGCATTGCGTACCACCCGCTCCAGGGTGGTGCCGATGAACAGGTCGC
+GCAGCGGCGTGTGCCGGTGCGCGCCCATCACCAGCAGGTCGGCGCCGATCTCCTCGGCCA
+CCGCGTTGATCACCACCACCGGATCGCCGACCCGCACGATCGCCTTGGACTCGACGCCGA
+GGCGCTCCTTCAGGGCCTGTCCGTTCACTTCCAGCAGGTTGGCGATGGCCAGCCGTTGCG
+GCGCGATCAGCACCGGCGGCTGGTCGTCGTCGAGCACGTTCAGCACGGTCAGTTCGGCAT
+TCCTCGCCTTGGCCAGCGCCGCGGCGCGCATGACCGCCAGCTCGGAACGCGAGGACAGGT
+CGGTCGCCACCAGGATTCGTTTCATCTTCCACCTCCATTGGCAGAGCGTTGAACGTCGGC
+CCCATTGAACGATCGACGCGACCGCTGCCGGTTGATGTGCATCAAGCGGATGCTTCGGAC
+TGAAACAATTGATAGGTGATTCCGCCGGCCGGGCCAATGGCCGCTGCGCCAGGCTCAGCG
+CTGGCTCAGGGCGAAAGCCTGGAGTTGCGGGTAGAAGGCGCGGAAATCCGCGCTCAGGTC
+ATCGTAGCGCTGGGCCAGTTCTTCCCAGGAACCGTCCAGCAGGTGCGGTCGCGACAGCCT
+CCGCGACATGCCGCCCAGCACTTCGCGCAAGACCGCGAACTCGCGGTAGCTGCCCAGCCA
+GTCCTGGGCCGCCATCCGCGGCGCGATGCGCGCCAGGCGCTCCGGCAGCGGCGAGGCGGT
+GCGCAGAGTGCCGTAGACCCGCTCGACGAACTGCGGCAGCGGTTCGTCGGCGTAGTCGTT
+CCAGTCGCGCGCCAGGCAGTGGTCGAAGAACACGTCCAGCAGGACGCCGGCGAAACGCCG
+GCGCTCCAGCGGGAAGCGCCGCTTGGCCGCATGCACCAGTGGATGGCTGTCGGTGAAGGC
+GTCGATGCGCCGGTGCAACTGGATGGCCCGCTCGATCTCGCCCGGCCATTGTCCCTGCAG
+GCGGCCCTTGACGAAGTCGCCGTACAGGCTGCCGAGCAGTTGGGCCGGTTGCGGGCCGCC
+GAGGTGGAGATGCGCGAGGTAGTTCATGCGGGCTAGCTTACCCCAGGGACGGAACCGTCG
+TTTCGATCATCGTCATCAGCCCTGTCGATAGCGACTATCGTCGCAATCGATCCCCATATC
+GTCCCACACCGATATATAGTTCGTCCCAACCCGATATGGACGGCCAACGGACCACCGCCA
+TGCCACTGGACATCGACGAAATCATCAAGGCTCTCTCCCACCCGGTGCGACGCGACATGC
+TGCGCTGGCTGAAGGAACCGGAGAAGTACTTCGTCGAGCAGGACCACCCGTTCGAGATCG
+GCGTCTGCGCCGGCAAGTTCGACCAGCGTACCGGTCTCTCCCAGTCCACCGTGTCGGTAC
+ACCTCGCCACCCTGCAACGCGCCGGTCTGGTGACCAGCCGCCGGGTCGGCCAGTGGAATT
+TCTTCAAGCGCAACGAGGAGACCATCCAGGCCTTCCTCGACCAACTCGGCGACGAGCTGT
+AAGCAGCACTCGCTTCCACCCCACCACCTCGCAGTCCAGGAGCTCGACCGATGCCGGCGT
+CTCTTCTCGTCCTCGCTTTATCCGCCTTTGCCATCGGTACCACCGAATTCGTCATCATGG
+GCCTGCTGCCGCAGGTCGCCGGCGACCTGCGGGTATCCATTCCCAGCGCCGGCTGGCTGA
+TCAGCGGCTACGCCTTCGCCGTGGCCTTCGGCGCCCCGTTGATGGCCATGGCCACCGCCC
+GCCTGGAACGCAAGAAAGCCCTGCTCGCGCTGATGGGCATCTTCATCGTCGGCAACCTGC
+TCTGCGCGGTGGCCGCCAACTACGGCCTGCTGATGCTGGCGCGGATCGTCACCGCGCTCT
+GCCATGGCGCCTTCTTCGGCATCGGCTCGGTGGTCGCCGCCAGCCTGGTGGCGCCGAACC
+GCCGCGCTTCCGCCGTGGCCCTGATGTTCACCGGCCTGACCCTGGCCAACGTGCTCGGCG
+TGCCGCTGGGTACCGCGCTCGGCCAGGAAGCCGGCTGGCGCGCGACCTTCTGGGTGGTGA
+CCCTGATCGGCGTGGTCGCCTTCGTCGGCCTGGCCAGGGTGCTGCCAAACGACCGCGAGG
+AAGAGAAGGTCGACCTGCGCCAGGAAATGTCCGCGCTGAAGAACCCGTCGCTGTGGCTGG
+CCCTGGGCACCACCGTGCTGTTCGCCGCCTCGATGTTCGCCCTGTTCACCTACGTCGCGC
+CGCTGCTCGGCGAAGTCACCGGGGTCAGCCCGCGCGGCGTGACCTGGACCCTGCTGCTGA
+TCGGCGTCGGCCTGACCGTCGGCAACGTGATCGGCGGCCGCCTCGCCGACTGGCGCCTGG
+GCACCACCATGGCCGCGGTGTTCGCCGCCATGGCGCTGGTCTCGGCGCTGTTCAGCTGGA
+CCAGCCAGGCCCTGCTGCCGGCGGAAATCACCCTGTTCTTCTGGGCCGCCGCCGCCTTCG
+CCGCGGTGCCCGCACTGCAGGTCAACGTGGTCCGCGTCGGGCATGCCGCGCCGAACCTGG
+TGGCGACCCTGAACATCGGCGCCTTCAACGTCGGCAACGCGCTCGGCGCCTGGGTCGGCG
+GCAGCGTCATCGACCACGGCCTGGGCCTGACCCGCGTGCCGCTGGCCGCCGCCGCGCTGG
+CCGCGCTGGCGCTGCTGGCCACCCTGATCGCCTTTTCCGGAAACGGCCGCGCCCAGGCGC
+AGCCGGTCCTCGATTGATCCCCTGTCCGTCTATTCCCTAGTGGAGGATGTTCCATGGCTA
+CTCTGTTCGATCCCATCGTGCTCGGCGACCTCGAGCTGCCCAACCGCATCGTCATGGCGC
+CGCTGACCCGCTGCCGCGCCGATGAAGGCCGCGTGCCCAACGCCCTGATGGCCGAGTACT
+ACGCCCAGCGCGCCGATGCCGGCCTGATCCTCAGCGAGGCCACCGCGGTCACGCCGATGG
+GCGTGGGCTACCCCGACACCCCCGGCATCTGGTCCGATGACCAGGTCCGTGGCTGGAGCA
+ACGTGACCAAGGCGGTGCACGCCGCCGGCGGGCGCATCTTCCTGCAACTCTGGCACGTCG
+GGCGGATTTCCGATCCGCTCTACCTGAATGGCGAGCTGCCGGTGGCGCCGAGCGCCATCG
+CCGCCGAGGGGCACGTCAGCCTGGTGCGCCCGAAGCGTCCCTACGTCACCCCGCGCGCGC
+TGGACACCGAGGAGATCGCCGACATCGTCGAGGCCTACCGCCAGGGCGCCGAGCGGGCCA
+AGGCCGCCGGCTTCGACGGCGTGGAGATCCACGGCGCCAACGGCTACCTGCTCGACCAGT
+TCCTCCAGGACAGCACCAACAAGCGCACCGACCGCTACGGCGGCTCCATCGAGAACCGCG
+CGCGCCTGCTGCTGGAGGTCACCGACGCGGCGATCTCCGTATGGGGCGCCCAGCGCGTCG
+GCGTACACCTGGCGCCGCGTGCCGACTCCCACGACATGGGCGATTCCAACCGCCTGGAAA
+CCTTCAGCCATGTCGCCCGTGAGCTGGGCAAGCGCGGCATCGCCTTCATCTGCGCCCGCG
+AAGCGCAGGCCGACGACAGCATCGGCGTAGCCCTGAAGAAAGCCTTCGGCGGACCCTACA
+TCGCCAACGAGCAGTTCACCCTCGACAGCGCCAACGCCATCCTGGCCAAGGGCGACGCCG
+ATGCGGTGGCCTTCGGCGTCCCCTTCATCGCCAACCCGGACCTGGTCGAACGCCTGCGCC
+AGGGCGCCGAACTGAACCCGCCGCGCCCGGAAACCTTCTATACCGGCGGTACCGAAGGCT
+ACCTGGACTATCCGACCCTGGCCTGATCGCGCCAGCCAGGAAGAGCCCGCCACGCTTGTC
+GTGGCGGGCTCTGTGCTTTGCCCGTCTAGCGCAGGCGGAAATACGGCTCCGGCTCCGCGC
+ACGGATCGCGCTGGGCGCAGCCCTTGCAACCGCCGCCGCAACCGCCCGAGCTTTGCGCAG
+CCACCCGCTCGACCTTGCCGAGCGCGATCAGCCGCTCCAGGATCGCCTCCACCAGCGCCG
+GCGGCGCGTCCACCTGGCGGCTGAGCTGTTTCAGCCCACGCGCCTGGCCGTCTTCCAGGG
+CGGCGCGGAGCTGCATGAGTGTCGCCATCAGTGACATCCTCCCTGCCCGCTCGGGGCATC
+GGCCATTCGGCCTGGCAGTTGCAGTACCTGCTCACGGCCGAACAGACGCAGGCAGGTCAT
+CAGGATCAGGTTGAAGAGCAGCACCACGGCGATGGTCAGGACGCTACGCTCGGGGTGCGC
+GGCGAAGGTGGCGACCTGGTAGCAGAGGGTCGCCAGCGAGTAGGCGACGTTCAGCCCCCA
+GAGCACCGAGAAAGCCATCCAGCCCTTGCTGCTTTCCCGGGCGATCGCGCCCATGGCGGT
+CACGCAGGGCACGTAGAGCAGGACGAAGACCAGATAGCTGTAGGCCGCGATGGGGCTGCC
+GAACTTGCTCGCCATGGTGCCCATCGAGCCGGTCTCCATGTCGCCGTCGGCCATGCTCGC
+CTCCACCGGGTTGGCCAGCACGCTGAGGCTGAAGGTATCGACCAGGCCGTCCCAGGTCTC
+GACCAGGGCCTCGCGCAGTTGCCCGGGCAGGTCGTAGCCTTCGTAGTCGAAGGCCTCGCC
+CTGGATCTGCTCGGCGGTGTAGAGGGTGTTCAGGGTGCCGACCACCACTTCCTTGGCCAT
+CGCCCCGGTGACCAGGCCGACGGTGGCCTGCCAGTTGTCCGGCTGCACCCCGAGCGGCGC
+CAGCAGCGGAGTGAGACGCTGGCTGACGCTGGCCAGCGCGGAATGGCCGATGTCGCCCTG
+CACCGGCTTGCCGTCGAGGGTGATGCTGTTCAGGCCGCCGATCACCAGGCTGACCAGGAT
+GATCACCTTGCCGGCCCGCACCACGAAGCCGCGCAGGCGCGACCAGGTCTGCAGCAGCAG
+GCTCTTAAGGTGTGGCACATGGTACAGCGGCAGTTCCATGACGAACGGCGAGGCCTCGCC
+GCGCATCAAGGTGTGCTTGAGCAACAGCCCGGTGAGGATCGCCACGACGATGCCGAGCAG
+GTACAGGGAGAAGATCACCAGCGCGCCGCCCTGGCCGAAGAAGGCCCCGGCGAATACGGC
+GAAGATCGCCAGGCGCGCGCCGCAGGACATGAACGGCGCCATCATGATGGTAATCAGCCG
+CTCGCGCTGCGCGTCCAGGGTCCGCGCGCCCATGATCGACGGTACGTTGCAGCCGAAACC
+GACGATCAGCGGCACGAACGACTTGCCCGGCAGGCCCAGCGCCTGCATCAGGCGGTCCAT
+GACGAAGGCCGCGCGTGCCATGTAGCCGGAATCCTCGAGCAGCGAGAGGAACAGGTACAT
+CAAGCCGATCTGCGGCACCAGCGGCAACACCGTGTTGACCCCGCCACCGATGCCCTGGGC
+GAGGAACACCGTGAGCCAATCGGGCAGGCCGAAGCGGATACCCAGCCACTGGATGCCGTC
+GATGAAGATCGCCGACGAGCCCTTGTCGAAGATCGGCTGTAGCGCCCCGCCGATGTTGAT
+GGCGAAGAAGAACATCAGGTACATCACCAGCAGGAAGATCGGCAGACCCAGCCAGCGATT
+CAGGACGACCCGGTCGAGCCATTGGGTCAGCCGGTGCGGCTGAGCCTGCTGGTGGTCGCA
+GACCGCCGCACAGATCTCGCCGATCAGTCGGTAGCGCGCATCGACGATCGCCAGCTCGGG
+CTCCTCGCCGCAGCCCTGGCGCGCCTGTTCCAGGGTGGCGGGCGGCAAGCCCAGCGCCGG
+GCCGTTGAAGATGTCGCCTTCCAGCGCCTGTAACGCCAGCCAGCGCGGCTCGATGGCCGA
+GGCCGCCGGAGCGCGCGTTTCCAGAAGGTAGCCGACCTGCGCCTGGATGGCCGGTGGGTA
+ATCCACCGCCAGCGCCGCCTGCGGGAGCTGTAGGGAGTCGATGGCCGCCTTCAGTTCGTC
+GATGCCATCGGCGCGGGTGGATACCAGCGGCACCACCGGGCAGCCGAGACGCCGCGCCAG
+ACCGTCGATATCGATGCGGATGCGCTGGCTACGGGCGATGTCGAGCATGTTCAGCGCGAC
+GATGCAGGGGATGCCCATCTCCCGCAGTTGCACCGTGAGGTACAGGTTGCGCTCCAGGTT
+CGCCGCATCCACCACGTTGACCAGCACGTCCACTTCGCCGCTGGCGATGTAGCGGCAGGC
+GATCTGCTCGTCCAGCGAGGCCTGGGCGGAAACGCTGGTCAACGAATAGGTGCCGGGCAG
+GTCGACCAGGCGTACCGCGTGACGGACGGTATGGAACGCACCCTCCTTGCGCTCCACGGT
+GACGCCGGCCCAGTTGCCGACCCGCTGGCGCGAGCCGGTGAGCTGGTTGAACAGGGTGGT
+CTTGCCGGAGTTGGGATTGCCGATCAGGCCGAGGGTCAATGCGGTCATGGGGATTCCGGG
+CGGGGTCAGTCGAGCGGGACGAGGGTCAGCAGGGCGAGGTCCTTGCGCCGCAGCGCCAGG
+CTGGTCTGGCGGGTCTCGACCTGGATCGGGTCGCCCAGCGGGGCGATGCGCACCACGCGC
+AGCGCCGCGCCGGGCAGAAGCCCCATGGAGAACAGGCGTTGGCGATAGCCGTTGCTGATG
+GCGGGGGAATAACCGGTGATGCGGTAGGAACGGGACGGTTGCAATGCGCTCATGGCGGAT
+TCCAGGCAGAGGAAGGGACCAATGGCCTCCCTGGCCGGTGACCGAGAATCTAAACGACTC
+TCACTTAAGGCTCGCTTAAGGACGCAGTATCGGAGTGGAGGAGCAGCGGATTCGCTGATC
+CAGAGCAATGGAAGCGGGGATTTTCGCCGGGCGCGGCGAACTGTCGCCGCCAGCGCCCGG
+TGCGACGGGCGGCTGGCGGCGCAAGGGGTCAGCGGGTATTGAGCTGCTGCTGCAGGTTCT
+GCACCTGGGCCTGGAGGGTGTTGATGTTGCGCATCACCTGGGTGCGGAAGGCGTCGAACT
+CGGCGGTATTGCCGCCCTGGGCCGGGCGGTTGTCGAGCTGGCTGCGCAATACCAGCAGGT
+CATCCTGGATACCCTTGATCGTCTGGCTCGGGTTGCCCTGCTTCTTCAGCGCCGCGACAT
+CGCCGCCGAGGGCCTTGAGTTGCTCGTTGGTCTTGCCCAGTTCGACCTGCAGGGCTTTCA
+GCTTCTCCTGTTCGGCGGCCAGTGTCTGCAGCTTGCCGTCCAGTTGCGCGACCAGTTGCG
+CCGCGCTTTCCTGCTGGGCCTTGAGATCGCTGGCCAGTTGGTCGAGGCGTTTGCCCTGGC
+CGCCGAACTGGTTGCTCACATCGGCCTGCTGGCGTTCCTGGCTGCCGAGTTTCTCCTGCA
+GTTGCTTGACCTGCAGGCGCAGCGCCTCGCGTTCGCTGGTGACGCTGGACTCGCTGGCGA
+CCACCTTGCCGCGAATGTCGTCGAGGCGCCCGGCGGCTTCTTCGCTGATCCTTACGAAGC
+TTTCCTGGGTCGCCACCAACTGCTGTTCCATCAGGCTGATTTGCTGGTGGCTCCACCAAC
+CCACCCCGGCGAGGGCGATCAGCATCGCCCCGAGCAGGGCCCAGAGCGGGCCGGTAGAGG
+CCGGACGGCGCTCCTTGGTGTCGACGACCCGGCGCTGCTCCGGTTCGTAGACGTGCCGCG
+GGTGGTGGCCGAATTCATCACGGTCGGCAGCATCGGTGGTCAGGCTGGGCACATCGTCGA
+GTTCGTCGAAAGCATCGTTACGCATGGTGAAAACCTGTGAAGGGGAACGGCATCCTGCCG
+GAGGCCTGGAGAAAGGGCCGAATGGCGCATTATATCGGTTCGGCCCCGCCCCTTCAGCGT
+CTGCTCGAAGCAAATTGCCGGACCGGGGCGCTCCACCGCGAAGCCGTGCGCCCCAAGACG
+GAGCGAACGCTGTCCGGCACAGACCGCCGCAGGCCGCCAGCGGTTCCCCGCCCCGCACGC
+CGGCGCTGGTCCGCGGCCCGCATGGCACGTCGCTTGCTTGGGCATTGCCGGGCAGATTCG
+AGAGCCGGAGGATGCATGGAGTTGAACAAATCCTTGCTGGATTGCATGCGCGCCGTGCGC
+CGACGACTACGCGAGGAACAAGCGCTGGATATCCACTTCCAGCAACGCGATGCGATCGCC
+GCGATGCAGGCGGCCTGCGCCCGCTCCGGCGATGCGACGACGCGGGAGCTGGGACAGCGC
+CTCGGCAGGCTCAGCGGGGTCGCGCTGCCGCCGGCGGAACCTTCCCTGTTGCCCGCGCAG
+GCGCCGAGCCGACAATACGCCGGCCCGCTGCGCGGCTGATCAGAGTCCCTGGGCGCGCCA
+CCAGGCGCAGAACTCGTCGAGCGCGGTCCACAGGCTGACCCGCGGGTCGTAGTCGAGGTA
+TTCGCGGGCGCGGTTGATGTCCAGGGTGAAGTTCTTCGCCATCACCGCCATGCCCAGGCG
+GAACAGCACCGGCTCCGGGCGCCCCGGCAGGATCCGGCAGACGCCTTCGTTGAGCGCCGC
+CAGGCCATAGCCGACGGCATACGGCAGGTGACCGCCGACCGGCGGCAGGTCGAGCTGGCG
+CATCACGTAGTTGACCGCATCCCAGAACGGTACCGGCTGCCCGTTGCTGATGTTGTAGAC
+CTTGCCCAGCGCCGGCTCGCCGGCCAGCAGGCAACTGAACAGCGCGTCGTTGAGATTGTG
+CACGCTGGTGAAGTCGACCCGGTTCAGGCCGTTGCCGAGGATCCGCAGGCGTCCCTTGCG
+GTGGGCCTGGATCATTCGCGGGAAGATGCTGGTGTCGCCGGCGCCGACCACGAAGCGCGG
+ACGCAGCGCCAACACTTCCAGGCCCAGGTCGCGGGCGCTGAGCACCAGTTGCTCGGCCTG
+GTACTTGGTCGCCCCGTAATGGTCGGAAAAACGCCGGGGTACGTACTCTTCGTTCAGGTC
+CAGGTGGTCGCGCCCGTCGAAATAGATCGACGGCGACGACAGATGCACCAGGCGCCGCAC
+CTTTTGCCGCATGCAGGCCTCGACGACGCTCTCGGCAAGCCCGACGTTGGCCGCCAGGAA
+GCGTTCGCGCGGTCCCCAGACTCCGACCGCGCCGGCACAATGCACCACCGCCTCGACATC
+CTCGCAGAGGCGCAGGACCAGCGCCGGGTCGGCGAGGTCGCCGGGAACGAACTCGGCGCC
+CCGCGCCACCAGATGTTCCACCGCGTCCGCACGACGACCGCTGACCCGTACCGACAGGCC
+CTGCTCCAGGGCGAAGCGAGCGAAACGCCCGCCGATGAAGCCCGTCGCCCCCGTTACCAG
+AATCCGCATTGCGTTTCTCCCGTTGTTCTTCTTGTGCCGCGACTCTAGCAACCCGGAGCC
+GCGCCACCACTGGCACAGCATGCCAGAACAACGACCTTGCGGGCCGCCGGCACGACTTGC
+GTTGGGCGACAGAAGCGGCGCTGCGCGCTACAAGGTCTAACCTGAAAGCCACCTGCACGC
+TGGGAGACGCACCATGGCCAGTCACTGGATGATCTACGGCGCCAACGGCTACACCGGCCG
+GCTGGTCGCTGAACAGGCGCAGCGCGAGGGCCTGACGCCGCTCCTCGGCGGACGCAACCC
+GGCCGCCCTGCACGCCCTCGGCAGTCAGCTCGGGCTGGAGTGCCGGGTCTTCGACCTGGG
+GGATCCGCAGGCCTGCCGCGAAGCCCTGGACCAGGTGAAGGTGGTGGCCCATTGCGCCGG
+TCCGTTCTCCGCCACCAGCACGCCGATGATCGCCGCCTGCCGCGCCGCCGGCACCCACTA
+CGTGGATATCACTGGAGAGATCGCGGTGTTCGAGCAGGCCCACGCCGGCGACGCCGAGGC
+CCGCGAGGCCGGCATCGTGGTCTGCCCGGGCGTGGGCTTCGATGTGATCCCCACCGATTG
+CCTGGCCGCCTGCCTGAAGGAGGCGCTGCCGGACGCGCAACGGCTGGCGCTGGGCTTCGT
+CACCGGCAGCGGGCTTTCGACGGGAACCGCGAAGACCAGCGTCGAAGGCCTCAAGTTCGG
+CGGCAAGATCCGCGAGAATGGCCGCCTGCGCGACGTGCCGTTGGGCTACAAGCGCCGCGA
+CATCGATTTCGGCCGCGGCCTGCGGCACGCCGTGACGATTCCCTGGGGCGACGTGGCCAC
+CGCCTACTACAGCACCGGCATCCCGGACATCGAGGTCTACCTGCCGGCGCCGCCGCTGCT
+GGCCCTGGGCATGCGCCTGATCGATCCGCTGCGTCCGCTGCTCGGTCGGCAACGGGTCCA
+GGACTGGCTCAAGGGGCAGGTCGACAAACGCATCGCCGGCCCCGACCAGGCGGCCCGCGA
+GCGCCTGCGCACCTGGGTCTGGGGCGAGGCGCGCAACGCCCGCGGCGAACGCCGCACGGC
+GCGCCTGGAGACGGCCAACGTGTACGACCTGACCCTGCACGGCGTGCTCCTGGCAGTGCG
+CCACCTGCTGGACTACCAGGGTCCCGGCGGCTATTTCACGCCATCGCGGTTGCTCGGCGC
+GCGCTGCGTCGAATCGTTGCCCGGCTCCGGACGAATCACCGTCATCGGCTGATCAGCCTG
+ACACCCGCACCAAGCCGTCGCCGGCGCGGGCGAGCAGGTGCTCGGTGAGCGACGCGAGCA
+GTTCGCCGCCGTTGCGCCAGTAGTGCCAGTACAACGGTACGTCGATGACCTGGCCGGGCA
+GCAGCTCGACCAGTTCACCGCGCGCCAGCTCGCCTTGCACCTGGCGCTCCGGCACCAGGC
+CCCAGCCGAGACCGCCGGCGGTGAGGCGGACGAAACCTTCCGAGGACGGGCAGAGGTGGT
+GGATGAAACCGCCCTCGACGCCGAGGTCCTTGAGAAAGCGGTGTTGCAGCAGGTCGTCCG
+GGCCGAACACGATCGCCGGCACGCCGGCCAGGGCGGCCGCCTCGACCCCGCGGGGAAAGT
+GCCGGGCAATGAAATCCGGGCTGGCCAGGCCGCGATAACGCATGGCTCCGAGCAGCAGCG
+AACGCGCGCCGGCCACCGGCCGCGCGCTACCGCAGACGCAGCCCGCCACTTCGCCCGCGC
+GCATGCGCTTGAGCCCGACCTCCTGGTCCTCCACCACAAGGTCCAGCAGCACCCGCCGCT
+CGGCGCAGAAATCGCCCACCGCGGCGGCCCACCAGGTCGCCAGGCTATCGGCGTTGAGAG
+CGATGCGCAGGCGTTCCGGGGCACCGCCCTCATCCAGGTTCGGCACCCAGCGCTGCAGGT
+CGCCCTCCAGCAGCCGCACCTGCTGCACATGGTTGAGCAGGCGGCGCCCGAGATCGGTGG
+GATGCGGCGGCGTCTCGCGCACCAGGACCGGCTGGCCGACCCGCGCCTCGAGCAGCTTGA
+TCCGCTGCGATACCGCCGACTGCGACAGCCCCAGCGCCTGTGCGGCGCGCTCGAAACCGC
+CCTGCTCCACCACTGCGGCCAGCGCGGCGAGCAACTTGTAGTCGAACAAAATCAGTTTTC
+CTAATGAGAGATCAGCAGGATTCGTTTTCCTTATAAACCGCCCGCGGCCACACTCGCCAG
+CACTTTTCCGATCCACCCGACGCGGACCGACCATGGCTGGCGAAACCTCGCTGCGCACCC
+TGCTGCGCACGCTCACTCCCGAACTCAATCCCGGCGACTATGTGTTCTGTACCTGCGCCG
+CTGGCGCGCTGCCGAACGGCGCCGAGCCGCTCGCCAGCTTCCGCGAGCGCGAGGGCCTGA
+CCCTGGTGCTCGAACGCCGGCAGGCCGAACGCCTGGGCCTGCCCTACGAATACGTGGCGG
+CCTGGATCACCCTGACGGTGCACTCCTCGTTGGCGGCGGTGGGCCTGACCGCCGCCTTCG
+CCACGGCGCTGGCCGAAGCCGGGATCAGTTGCAACGTGATGGCCGGCTATTTCCACGACC
+ACCTGTTCGTCGCCCGCGACGAGGGCCGGCGCGCCCTCGCCGTGCTCCAGCGGCTGGCGG
+CGGAGGCACACTGACATGTGGCAGAGCTATCTCAACGGCATCCTGGTGGCTGCCGGCCTG
+ATCATCGCCATCGGCGCGCAGAATGCCTTCGTCCTCGCGCAGAGCCTGCGCCGCGAGCAT
+CACCTCTCGGTAGCCGCGCTCTGCGTGTTCTGCGACGCGGTGCTGGTCAGCCTCGGCGTG
+TTCGGCCTGGCCAAGCTGCTGCTGGAAAACCCGACGCTGCTGGCCATCGCCCGCTGGGGC
+GGGATCGCCTTCCTGACCTGGTACGGGCTCAAGGCGCTGCTTCGCGCGTTGCGCCCGGAC
+GCCCTCGGCAACGCCGCGGAAACCGGGCCACGCTCGCGCAAGGCGGTGCTTCTGGCGGCA
+CTGGCGGTCACCCTGCTCAACCCCCACGTCTATCTCGATACCGTACTTCTTATCGGTTCG
+CTCGGCGCCCAGCAGGCCGCGCCGGGCGCCTATGCCCTCGGCGCGGCCAGCGCCTCGCTG
+ATGTGGTTCTTCGCCCTCGCCCTCGGCGCGGCATGGCTGGCCCCCTGGCTGGCGCGCCCG
+GCCACCTGGCGCCTGCTCGACCTGATGGTGGCGGCCATGATGCTGGGCATGGCCGCGCAA
+CTGCTGTTCCGGGGATAACGCGGTTTCTGTCTTCCCGAGCGAACCCTCGCGCCGCCAGGC
+AGTCCAGAGAGAATGTGGCGGTGTTCGCCGGCGAGCTTGCAGAAGCCCGTCGCAGCGCGC
+CGCCGCCGGCCTTTGCCCCTACAGTTGCTGCGTGGATATGCCCCGACACGGGTGCTATGA
+TCCGGAGTTCGCGGCACTGGGAGCCTAGGCTCCGAGTCGCACCCGGCGCCCTTTCCGGAG
+CGCTCCGCCGAACGTCCCCCCCGGGGATCCAGGACGGGCTCCCGGACAGGCATCGGACCG
+GCCCCGTGAACCGGTCGCGCGCTAGCCGCGCCAGTCCTGACCTGAGGAAGAATAGGAGAG
+ACACCATGGCTTTCGAATTGCCGCCGCTGCCTTACGAAAAGAACGCCCTTGAGCCGCACA
+TTTCCGCAGAAACCCTGGAGTACCACCACGACAAGCACCACAACACCTACGTGGTGAACC
+TGAACAACCTGATCCCGGGCACCGAGTTCGAAGGCAAGAGCCTCGAAGAGATCGTCAAGA
+GCTCCTCCGGCGGCATCTTCAACAACGCCGCCCAGGTGTGGAACCACACCTTCTACTGGA
+ACTGCCTGAGCCCGAACGGCGGTGGCCAGCCCACCGGCGCCCTGGCCGACGCCATCAACG
+CCGCCTTCGGCTCCTTCGACAAGTTCAAGGAAGAGTTCACCAAGACTTCCGTCGGCACCT
+TCGGTTCCGGCTGGGGCTGGCTGGTGAAGAAGGCCGACGGCTCCCTGGCCCTGGCCAGCA
+CCATCGGTGCCGGCAACCCGCTGACCAGCGGCGACACCCCGCTGCTGACCTGCGACGTCT
+GGGAACACGCCTACTACATCGACTACCGCAACCTGCGTCCGAAGTACGTCGAGGCGTTCT
+GGAACCTGGTCAACTGGGACTTCGTAGCGAAGAATTTCGCTGCCTGAGTCTGATCAGAAC
+CACGAAAAAGCCCGGCATTCGCCGGGCTTTTTCGTTTTAATCTGCGGTCCAGGAGCCATC
+GTCTACCCTCAGGAACTGGTAGACCTTCGCTCGTGATAGCCTCTTGAGGTAAACAAGCTC
+TTCCTACCGGCTTGTCTTTCGCCCTGGCGACGAACAAGGAAGGCCCCTTGAAACTGGACT
+CCCGACACAGCCTCTCGCTCAAGCTGCTGCGTGTCGTGCTACTGGCGGCGCTAGCCGTTG
+GCGTAGTGCTCAGTTGCGCGCAGATCGTCTTCGACGCCTACAAGGCCAAGCAGGCGGTGA
+GCAGCGACGCCCAACGCATCCTCGCGATGGTCCGCGACCCTTCCACCCAGGCGGTCTACA
+GCCTCGACCGGGAAATGGCGATGCAGGTCCTCGAAGGCCTGTTCCAGCACGAGGCGGTGC
+GCCAGGCGAGCATCGGCCATCCCGGCGAGCCAATGCTGGCGGAGAAATCCAGGCCGCTGC
+TGGACCTGCCGACGCGCTGGCTGACCGACCCGATCCTCGGCCAGGAACGCACCTTCAGCA
+TTCGACTGATCGGCCGCCCGCCCTATAGCGAATACTACGGCGACCTGAAGATCACCCTGG
+ACACCGCGCCCTACGGCGAGAACTTCGTCACCACTTCGGAAATCATCTTCATCTCCGGCA
+TTCTCCGCGCCCTGGCCATGGGCCTGGTGCTGTTCCTGGTCTACCACTGGATGCTGACCA
+AGCCGCTGTCGAAGATCATCGAGCACCTGGTCAGCATCAATCCCGACCGCCCCAGCCAGC
+ACCAGTTGCCGCTGCTCAAGGGGCACGAACGCAACGAGCTGGGGCTCTGGGTGACCACCG
+CCAACCAGTTGCTCGCCTCGATCGAAAGCAACAGCCACCTGCGCCGCGAGGCCGAGGACA
+ACCTGCTGCGCATTTCCCAGTACGACTTCCTCACCGGCCTGCCGAACCGCCAGTTGCTGC
+AGCAGCAACTCGACCAGATCCTCGACGGCGCCGGCCGCCAGCAGCGCCGGGTGGCAGTGC
+TGTGCCTGGGCCTCGACGATTTCAAGGGGATCAACGAGCAGTACACCTACCAGCTCGGCG
+ACCAGCTGCTGATCGCCCTCGCCGACCGCCTGCGCGGGCACAGCGCGCGGCTCGGTTCGC
+TGGCGCGCCTGGGCGGCGACCAGTTCGCCCTGGTCCAGGCCGACATCGAGCAACCCTACG
+AGGCGGCCGAACTGGCGCAGAGCATCCTCGACGGCCTGGAAGCGCCGTTCGAGATCGACC
+AGCACGAGGTGCGCCTGCGCGCCACCATCGGTATCACCCTGTTCCCCGAGGACGGCGAGA
+CCACGGAGAAACTGCTGCAGAAGGCCGAGCAGACCATGACCCTGGCCAAGACCCGCTCGC
+GCAACCGCTACCAGTTCTACATCGCCAGCGTGGACAGCGAGATGCGTCGCCGCCGGGAAC
+TGGAAAAGGACCTGCGCGACGCCCTGCAGCGCCACGAGCTGCACCTCGTCTACCAGCCGC
+AGGTGGACTACCGCGACCACCGCGTGGTCGGCGTCGAGGCGCTGCTGCGCTGGCAACATC
+CGTTGCACGGCTTCGTCCCGCCGGACCTGTTCATCCCGCTGGCGGAACAGAACGGCAGCA
+TCTTCAGCATCGGCGAGTGGGTGCTCGACCAGGCCTGCCGGCAGTTGCGCGAATGGCACG
+ACCAGGGCTTCGACGACCTGCGCATGGCGGTCAATCTTTCCACCGTGCAGCTCCACCACA
+ACGCCCTGCCACGGGTGGTCAGCAACCTGCTGCAGGTCTACCGCCTGCCGGCGCGCAGCC
+TGGAGCTGGAAGTCACCGAGACCGGCCTGATGGAGGACATCTCCACTGCCGCCCAGCACC
+TCCTCAGCCTGCGCCGCGCCGGCGCGCTGATCGCCATCGACGATTTCGGCACCGGCTATT
+CCTCGCTGAGCTACCTGAAGAGCCTGCCGCTGGACAAGATCAAGATCGACAAGAGTTTCG
+TCCAGGACCTGCTGCAGGACGAGGACGACGCGACCATCGTTCGCGCCATCATCCAGCTCG
+GCAAGAGCCTGGGCATGCAGGTGATCGCCGAGGGCGTGGAAACCGCCGAGCAGGAGGCGT
+ACATCATCGCCGAAGGTTGCAACGAAGGTCAGGGCTACCTGTACAGCAAGCCGCTGCCGG
+CCAGGGAACTGACCCAGTACCTCAAGCAGGCGCGACGCCTGAGCCAGGCCACCAGCAGCG
+AACGGCCCTGATCAGAACAGGCGGCTGAACAGCCAGCCCGCCAATAGCGCGCTGCCCAGG
+CAGAGCAACGCGGCCCCCGCCGCCTGGCGGCGCAGTTGCACGGCGAGATCGTCCTCGCCC
+TGGCTGGAGAGAATGAAGGGATGCGCCTCCCCCGGCTTGCCGAGCCGGTGGCGGGTCGGC
+GCGGCGCTGCTTGCCCGATGCCGATCCTCGGCCTCCAGCCGTGCCGCCAGGCGCACCCGG
+TTCCATTCGCGCTCGTCCAGCTCGCCGTTGCCGTCGCTGTCGAAGCGCGCCAGCAGGCCG
+TGGAAATCGCCCTTCCATTCACGGATCACCGCACCCTGCGCCCGTTCGGCATCGAGTCCC
+TGGCGACCGCCACCGCTGCTGCGGAATTCGCCCAGCGCATAGAGCGGCTCGCCGGCATGC
+AGGCGCTCCTCGGTGTAGCGGTAGAGCCGCTCTCCGCCGACCAGGGTGCCGAAGCTCTCC
+AGCAGTCGCAGGGTATCGATCGGTGCTTCGCGAAAAGCCTCCCAGCGCTGCAGGGTCAAG
+GGTCGCACCTCGGCGCCGCGTGGGTCGACCAGGCAGGCATCGGTGGCATCGCGCAAGCCG
+AATGGCGACTCGCTGGCACCTTTGTCGACGGTGCGCCAGGCCTTCTCGCGGCCACTGCGC
+TTTTCCTCGACTTCGATGCGGTAGCGCCACCACAGGCACGGCTTGCCGGTCAAGGGAGCC
+TGCAGCGGGCCTTCCGGGCCCTCCTCGAGCACCCCGTAGAGTTCGACGAAACCCTGCGCC
+GCCGAACGGATCCGCGAGGTCGGTACGTCGCCGAGCAGGCGCGCCCGGGCAAGGCGGTGC
+ACGAACTGCCAGCCGGCCCAGGCGCAGAGCCCCAGGCTGGCGGCGATGAACAGCCAGCGC
+AGGTCGAAGTCCATCTCAGCCGAACAGGGCCTTGAGATCGACGTCGGCCTTCTCCGCCTC
+GCTGAACTGCAACAGCTCGGCGGCCTTGAAGCCAGCGACACGAGCGATCAGCAGGTCGGG
+AAATTGCTCGATGCGCACGTTGTTCAGGTTCACCGCCTCGTTGTACAGCTCGCGGCGATC
+GGCGATCCCGTTCTCCAGGCCGCTGATGCGCTGGGAAAGGAACTGGAAACTTTCGTTGGC
+CTTGAGCTGCGGGTAGTTCTCGGCCAGCGCGAAGAGCTGCCCCAGGCCGGCGCGCAGGCC
+GCTCTCGGCCTTGCCCAGGGCATTCACGTCGGCGCGCTCGCGGGCGCTGGCGACGGCGTT
+GCGGGCGGCGATGACCCGCTCCAGGGTGGCGCGCTCGTGCTGCATGTATTGCTTGCAGGC
+CTCGACCAGCTTCGGCAACTCGTCATGGCGCTGCTTGAGGAGCACGTCGATGTTGGCCCA
+GGCCTTGCCCACGGCGTGCTTCAGCCGTACCAGGCCGTTGTAGAGCACCACCGCGTAGCC
+GGCGAGCAGCAGCAGGACAACCCAGAAAGCGATAGCGGTCAGACTCATGGACGGAGCTCC
+GGACGAAGATACTGGCATTCTAGCTGCGCCCGACATGTCCAGGCACGACGGCGATCACGC
+TGCGCCCTTTTCAAAAATGCAAATCTTTCGCATTATGTGGCGGTTTTTTAACGCCCTCGC
+GGGTGTTTCCGACAAGCGCACGCCGCTTCGGCACGCCACCAATAAAGCAAAGGAATCCGC
+CATGACTCGTATGCCCCTGGCCACCGCCAGTCTGCTGGCCCTCGCCATCTCCCTCGCCGG
+CTGCGGCGACGACAAGAAAGCCGAAGCGCCCGCAACACCGGCGGCCAGCACGCAGCCCGC
+CGCGCCCGCCGCCGCCCCGGCCGCCAAGGTCGACGAGGCCGCCGCCAAGGCGGTGATCAA
+GAACTACGCGGACCTCGCCGAAGCCACCTTCGCCGATGCCCTGAGCACCGCCAAGGACCT
+GCAGAAAGCCATCGACGCGTTCCTCGCCAAGCCTGACGCGGAGACCCTGAAAGCCGCCAA
+GGAAGCCTGGTTCGCCGCTCGTACCCCCTACTCCCAGAGCGAAGCCTTCCGCTTCGGCAA
+CGCGATCATCGACGACTGGGAAGGACAGGTTAACGCCTGGCCGCTGGACGAAGGCCTGAT
+CGACTATGTCGCCAAGGACTACCAGCACGCCCTGGGCAACCCCGGCGCCACCGCCAACAT
+CGTCGCCAACACCGAGATCCAGGTCGGCGAAGACAAGATCGACGTCAAGGAAATCACCGG
+CGAGAAACTGGCCAGCCTGAACGAGCTGGGCGGTTCCGAAGCCAACGTCGCCACCGGCTA
+CCACGCCATCGAGTTCCTCCTCTGGGGCCAGGACCTGAACGGCACCGGTCCCGGCGCCGG
+CAATCGTCCGGCCACCGACTATGCCCAGGGCAAGGACTGCACCGGCGGCCATTGCGACCG
+TCGCGCCGCCTACCTGAAGGCCGTCACCGACCTGCTGGTCAGCGACCTCGAATACATGGC
+CGGACAGTGGAAAGCCGGCGTCGCCGACAACTACCGCGCCAAGCTGGAGGCCGAACCGGT
+GGATACCGGCCTGCGCAAGATGTTCTTCGGCATGGGCAGCCTGTCCCTCGGCGAACTGGC
+CGGCGAGCGCATGAAGGTCGCGCTGGAGGCCAACTCCACCGAAGACGAGCACGACTGCTT
+CAGCGACGACACCCACCACACCCTGTTCTTCAACGGCAAGAGCATCCGCAACATCTACCT
+CGGCGAGTACAAGCGCATCGACGGCAGCGTGGTCAAGGGCCCGAGCCTGGCCGACCTGGT
+CGCCAAGGCCGACGCCGCCGCCAACGACACCCTGAAGGCCGACCTGGCCGACACCGAGGC
+CAAGCTGCAGGCCATCGTCGACAGCGCCGAGAAGGATGGCGTGCACTTCGACCAGATGAT
+CGCTCCGGACAACAAGGACGGCCAGCAGAAGATCCGCGACGCCATCGCCGCCCTGGTCAA
+GCAGACCGGCGCCATCGAGCAGGCCGCGGGCAAGCTGGGTATCCAGGACCTGAAGCCGGA
+CAACGCCGACCACGAGTTCTGATTCCTTCCTGCGCCAACAGCGTGCGGCCCATGGCCGCA
+CGCTGCGTTTCAGGGCCTCGAAAGCGGACTTCGCGGGCCTTTACAAACGCAAATCCCTCT
+TATTTTGATTAGCTCCAACTGGTAAGCTTGCGGGCTGTTTCTACGCAGTCCGGGATGTTC
+GCCGATGTCGTTGCCGTCACCTTCCATGCCGCTCGCCTGTCTCCTGACGGCGCTCCTTCT
+GGGCGGATGCGGCGCCGACGACGAACCGCTGCGCGCCGAGCCCGGCGAACACCTGTCCGG
+GGGCGCGACCACGGTGCTGCAAAGCGACCGCAACGCCTTCTCCCTGCCCTCCGCCAACCT
+CGCCCCGAGCCGGCGCCTGGACTTCAGCGTGGGCAACAGTTTCTTCCGCAACCCCTGGGT
+CATCGCCCCTTCCTCCACCACCGCGCGCGACGGTCTGGGACCGCTGTTCAATACCAACGC
+CTGCCAGAACTGCCATGTGAAGGACGGCCGCGGCCACCCGCCGGGAGCGGACGCGGTCAG
+CGCGGTGTCGATGCTGGTACGCCTGTCGATCCCGGCCGGCCCTGCGGACGGCAAGACCCT
+GTTGCACCAGGGGGTGATTCCCGAGCCGACCTACGGCGGCCAGTTGCAGGACGTCGGCAT
+TCCCGGCGTCGCCCCGGAAGGCAAGGTGCGGGTGGACTACGAGCCGCTGAAGGTGAGGTT
+CGAGGACGGCACCGAGGTCGAACTGCGCAAGCCGATCCTGCGTATCAGCCAGCTCGGCTA
+TGGGCCGATGCATCCGCAGACGATGTTTTCCGCCCGCGTCGCCCCGCCGATGATCGGGCT
+CGGCCTGCTCGAGGCGATTCCCGAAGAGGCGATCCTGGCCAATGCCGATCCGGACGACCG
+CAACGGCGACGGTATCCGCGGGCGCGCCAACCAGGTCTGGGATGCAGCGCGGCAGCGCAC
+CGCGCTCGGCCGCTTCGGCTGGAAGGCCGGCCAGCCGGATATCCCGCAGCAGAACGCGCA
+CGCCTTCGCCAACGACATGGGCCTGACCAGCAGCCTGCTGCCCCACGACGACTGCAGCGC
+CGCCCAGGTCGAGTGCCGCCGGGCGCCCGACGGCGGCGAGCCGGAAGTCAGCGACAACAT
+CTTCGCCCAGGTGCTGTTCTACAGCCGCAACCTGGCGGTCCCGGCGCGGCGCAAGGTGGA
+CGACCCGCAGGTGCTGGCCGGCAAGCGCCTGTTCGCCCAGGCCAACTGCGTGGCCTGCCA
+CGTTCCCGCCTTCACTACCGGTTCCGACGCCAGCGAGCCGGAGCTGGCCAACCAGCGGAT
+TCGTCCCTATTCCGACCTGTTGCTGCATGACATGGGCGACGGCTTGGCGGACAATCGCCC
+GGAATTTCTCGCCAGCGGGCGGGACTGGCGAACCCCGCCGCTATGGGGCATCGGCCTGAC
+CGAAACGGTCAACGGCCACACCCAGTTCCTCCACGACGGGCGCGCCCGCAATCTGCTGGA
+GGCGATCCTCTGGCACGGCGGCGAAGCCGAAGCGGCCAAGCGGCACGTACTCGGCTTCGA
+CGCCGACCAGCGCAGCGCCCTGCTGGCCTTCCTGAATTCACTCTGAGGAGCCCACATGTT
+CCGCCCACGACTGCTCTTGACCAGCCTCGCCATCGCCCTCGGCGCCTGCTCGCCGCAAGA
+CCCGCAGGCCGTCACCAGTGCCGCCCTGGCGCAACAGGTGATCCTGCCGACCTACAGCCG
+CTGGGTGGAGGCCGACCAGGCCCTGGCCAGCAGCGCCCTGGCCTACTGCCAGGGCAAGGA
+AGACCTGGCCAAGGCCCGCGACGCGTTCCACGCCGCGCAGAAGGCCTGGGCCGAGCTGCA
+ACCGCTGCTGATCGGCCCGCTGGCCGAGGGCAACCGCGCCTGGCAGGTGCAGTTCTGGCC
+GGACAAGAAGGACCTGGTCGGGCGCCAGGTCGAACAGTTGCTGAAGAACAACCCGCAGGT
+CGACGCCGCGGCCCTGGCCAAGGCCAGCGTGGTGGTGCAGGGGCTCTCCGCCTACGAATA
+CATCCTCTTCGACAGCAAGATCGACCTCGCCGACGCCGCCACCAAGGCCCGCTATTGCCC
+GTTGCTGGAAGCCATCGGCACCCACCAGCAGCAACTGGCCCAGGACATCCTGGCGCGCTG
+GAAGAACGACGGCGGCATGCTCACCCAGATGAGCAAGTTCCCCAACGACCGCTACGCCGA
+CGCCCACGAGGCGATCGCCGAGCTGCTGCGGGTCCAGGTCACCGCCCTGGACATGCTGAA
+GAAGAAACTCGGTACTCCGCTGGGCCGGCAGAGCAAGGGCATTCCCCAGCCCTACCAGGC
+CGAGGCCTGGCGCAGCAACGCCTCGCTGGCCAGCCTGGACGCCAGCCTGAGCGGCGCCCA
+GGCGCTCTGGGAAGGTATCGACGGCAAGGGCCTGAAGACCCTGCTGCCGGCCGAACAGAA
+GGACCTGGCCGGCAAGATCGACGCCGCCTACGCCGACAGCCACGCGAAGCTGGCGGCGCT
+GGAACAGAAACCGCTCTCCGAACTGCTCGCCAGCGAAGACGGGCGCAACCAGCTCAACGC
+CCTCTATGACAGCCTGAACGTGGTCCACCGCCTGCACGAAGGCGATCTGGCCCGCGCCCT
+CGGCGTGCAACTGGGCTTCAACGCCAACGATGGCGACTGAGGTCGGCACCATGCTGCGAC
+GTCATGTGATCGGCCTGGGCAGCCTGCTGCTCGGCGCCTTGTCCTTCGGCGGCTGGAGCT
+TCAGCCGCCTGGGTAGCCAACCGCTGGTGCTATCGGCGCGCGACGACGCCGATGGCCAGC
+ATTACGCGGTGGGCTACCGCCTGGACGGCAAGTGCCAGTTCGCCACCCGCGTGGCCCAGC
+GCTGCCACGACATCGTCCAGCACCCGAGCCTGCCGCTGGCGCTGTTCGTCGCCCGCCGGC
+CAGGCACCGAAAGCTACCTGATCGACCTGAACGACGGTCGCCTGCTGCAGACCCTGGTCT
+CGCAGAAAGACCGCCACTTCTACGGCCACGGCGTGTTCCACCAGAGCGGCGAGTGGCTCT
+ACGCCACCGAGAACGACACTACCGATCCCGGTCGCGGCGTGCTCGGCGTCTACCGTTTCG
+ACGGCGAGCGACTGCAGCACAGCGGCGAGATCTCCACCCACGGCCTCGGGCCGCACCAGG
+TTTCCTGGATGCCCGACGGCGAGACCCTGGTAGTGGCCAATGGCGGCATTCGCACCGAGG
+CGGAAAGCCGGGTCGAGATGAACCTCGACGCCATGGAGCCCAGCCTGGTGCTGATGCGCC
+GCGACGGCAACCTGCTGTCCAAGGAAACCCTGGCGCAGCAGATGAACAGCGTCCGCCACC
+TGGCGATCGGTCGCGACGGCACCATCGTCGCCGGCCAGCAGTTCATGGGCGATGCCCACG
+AACATGCCGACCTGCTGGCGATCAAGCGCCCCGGCCGTCCCTTCGAAGCCTTCCCGGTGG
+CCGAGGAGCAGCGCCTGGCGATGGCCCAGTACACCGCCAGCGTGGCGATCCACGACGACC
+TGCGCCTGGTGGCCCTGACCGCCCCGCGCGGCAACCGTTTCTTCATCTGGGACCTGGACA
+GCGGTGCCGTACGCCTCGACGCGCCGTTGCCGGACTGCGCCGGCGTGGGCGCGGTGAAGA
+ACGGCTTCGTCGTCACGTCCGGACAGGGCCGTTGCCGCTTCTACGACTGCCAGGGCGAGC
+GCATCGCCGCGCAACCGCTGGAGCTGCCTGCCGGCCTCTGGGACAACCACCTGCACCTGG
+CCTGAGAGCACGGCATCAACCTCTCGCCATACCGGTCCGCGAAAGTCGGAAGCGACCTGC
+AACACGCTTGAAATCTTTCGCCAATCCTGTGCTTTGACAAGCCCTGAAAGCTGCACGTAA
+TGTGTCGGATTCGCCCCGAAACGGGGCGCTCTCGGCATACCAGGGACCAGGATTATGTTG
+CTCCGCCGCATGTTGATCATGCTCGCCGCGGTGATCGCCGTGGTGGCGATTCTCGCCGGC
+TACAAGGTCTACTCCATCCGTCAGCAGATCGCCCTTTTCAGCGCACCGAAACCGCCGATC
+AGCGTGACCGCCAGCCTGGCCGAAAAGCGTCCCTGGCAGAGCCGCCTGCCAGCCATCGGC
+AGCCTCAAGGCATTCCAGGGCGTGACCCTCACCGCCGAAGTCTCCGGCACGGTACGCGAC
+GTACTGTTCCTTTCCGGCGACCAGGTGAAGCTGGACCAACCGCTGATCCAGTTGGAAAGC
+GACGTCGAGGAAGCCACCCTGCGCACTGCCGAGGCCGATCTCGGCCTGGCCAGGGCCGAG
+TACCAGCGCGGCCGCGAACTGATCGGCAGCAAGGCCATCTCGAAAAGCGAATTCGATCGT
+CTCGCCGCGCAGTGGGCCAAGACCAGCGCCACCGTCGCCGAGCTGAAGGCGGCGCTGGCG
+AAGAAGCGCGTGCTCGCGCCCTTCGCCGGGACCATCGGCATCCGCCAGGTGGACGTCGGC
+GACTACGTCTCGCCCGGGACGCCGATCGCCACCTTGCAGGACCTTTCCACCCTGCTCCTG
+GATTTCCACCTGCCCGAGCAGGACTTCCCCCTGCTCAGCCGCGGCCAGCTGGTGAAGGTC
+CGGGTCGCCGCCTACCCCGGCCAGGTGTTCGACGCCGAGATCGCCGCCATCAACCCCAAG
+GTCGACAACGAGACCCGCAACCTGCAGGTCCGCGCTGCCCTGGAGAACCCGGACGGCAAG
+CTGCTGCCGGGCATGTTCGCCAACCTCGAGGTGATGTTGCCTGGCGAGGAACAACGCGTC
+GTGGTGCCGGAGACGGCGATCACCTTCACCCTCTACGGCGACTCGATCTACGTCGTCGGG
+CAGAAGAAGGACGAGCAGGGCCAGGTGTCGAAGGATGACAAGGGCCAGCCGCAACGGGTC
+GTCGAGCGCCGCTTCGTCAGGATCGGCGAACGCCGCGAAGGCCTGGCGGTGGTGCTCGAA
+GGCCTGGAGGGCGGCGAGCAGGTAGTGACTTCCGGGCAACTGAAGCTCGACAACGGCGCC
+GCGGTGGCCATCGTCGCCGAGCGGGACCTCCAGCAAGAGCACTGAGTCGCGCGCCTTCCC
+ACTCCGTGGCGGAAGGCTTGCCAAGGGACTGAAACATGGCTTTTACCGATCCGTTCATCC
+GTCGTCCGGTCCTGGCGAGCGTGGTCAGCCTGCTGATCGTCCTGCTCGGCATGCAGGCCT
+TCAGCAAGCTGGTGATCCGCGAGTATCCGCAAATGGAGAACGCGCTGATCACGGTGACCA
+CGCTCTACGCCGGCGCCAACGCGGAAACCATCCAGGGCTACATCACCCAGCCGCTGCAGC
+AGAGCCTGGCCAGCGCCGAAGGCATCGACTACATGACCTCGGTGAGCCGGCAGAACTATT
+CGACCATCTCCATCTACGCGCGGATCGGCGCCAATACCGATCGCCTGGTCACCGAGCTGC
+TGGCCAAGTCCAACGAAGTGAAGAGCCAGCTGCCGCCGGACGCCGAGGACCCGGTGCTGC
+AGAAGGAGGCCGCGGACGCCTCGGCGCTGATGTACATCAGCTTCTACAGCGAGCAGATGA
+ACAACCCGCAGATCACCGACTACCTGTCGCGGGTGATCCAGCCCAAGCTGGCGACCCTGC
+CCGGTATCGCCGAGGCGGAGATCCTCGGCAACCAGGTGTTCGCCATGCGCCTGTGGCTGG
+ACCCGGTGAAGATGGCCGCGTTCGGCGTCACCGCCGGCGAGATCAACCAGGCGGTGCAGC
+AGTACAACTTCCTCGCCGCCGCCGGCGAGGTGAAGGGCCAGTTGGTGGTCACCAGCGTCA
+ATGCTTCCACCGACCTCAAGTCGCCCCAGGCCTTCGCCGCCATCCCGGTGAAGACCGACG
+GCGACCGCCGGGTGCTGATGGGTGATGTCGCACGGGTCGAGCTGGGCGCCGCCAGCTACG
+ACGCGATCAGTTCGTTCAATGGGATTCCCTCGGTCTACATCGGCATCAAGGGCACGCCCA
+GCGCCAACCCGCTGGACGTGATCAAGGAAGTGCGGGCGAAGATGCCCGAACTGGAAGAGC
+AATTGCCGCCCAACCTCAAGGTGTCCATCGCCTACGACGCCACGCGCTTCATTCAGGCCT
+CCATCGATGAAGTGGTGAAGACCCTCGGCGAGGCGGTGCTGATCGTCATCGTGGTGGTGT
+TCCTGTTCCTCGGCGCGTTCCGTTCGGTACTGATCCCGGTGGTGACCATTCCGCTGTCGA
+TGATCGGCGTATTGTTCTTCATGCAGGCCATGGGCTACTCGATCAACCTGCTGACCCTGC
+TGGCGATGGTCCTGGCCATCGGGCTGGTGGTGGACGACGCGATCGTGGTGGTGGAAAACA
+TCCACCGCCACATCGAGGAGGGCAAGCCGCCCTTCGAGGCCGCCCTGGAGGGCGCGCGGG
+AGATCGCCGTACCGGTGGTCAGCATGACCATCACCCTCGCCGCGGTCTACGCGCCGATCG
+GTTTCCTCACCGGCCTCACCGGCGCCCTGTTCAAGGAGTTCGCCTTCACCCTGGCCGGCG
+CGGTGATCATTTCCGGGATCGTCGCCCTGACCCTGTCGCCGATGATGTGCTCGCGCCTGC
+TGCGCCACGAGGAGAATCCCTCGGGCCTGGCGCATCGCCTCGACCTGATCTTCGAGGGCC
+TGAAGCAACGCTACCAGCGCGCCCTCCACGGCACCCTGGACACCCGTCCGGTGGTCCTGG
+TGTTCGCCGTGCTGGTACTGGCGCTGATCCCGGTACTGCTGATGTTCACCAAGAAGGAGC
+TGGCGCCGGAAGAGGACCAGGGCATCGTGTTCCT
+>NODE_10_length_39995_cov_63.156_ID_19
+TAGATGCTCAATGTGACATATACCACATCCACAATATACCATAATATGACAAACACCACA
+AAAAGTTCCATCCACAGAAACGCATTGCTGCGGCGCTCGTTCCATATCTGTTTCAATAAA
+TTCCTGTTCATGATCTAACGTTGGTTTAAAGCGTCCGTAATATTCATGCGCGATGCCCTC
+CAGGCAGGGATGCACGCTGACAGCAAATTCAAGAGAAGGCAGAAAATGAATGCGGCCAAG
+AATATCCAGGGACTGAACAACATATCTGCCGAAAGACTGGTTTCTCCTATTTGGGCACGG
+TTCTCGCTATTGGAAAATAAGAAATCATTCAATAAAAAAGTACATGCATAACTGAAAAGC
+ATTCCTACTGCTCCGGCTATGAGCGTCAATAATAAATTTTCATAAAACACTTGCCTCAAC
+AAGACATTGGCAGTAGCACCAAATGCCTTCCTCACCCCTATTTCCGACATGCGCTTCCGC
+ATACGGGACAAAGTCATGCTACTCAAATTTATAGCCGGTACCAGCAATAAAATAACAATC
+ACCAACAGGTAGTGCAAATAAGCTTCCTTCGCCTGTAACTCTCTTCCCCAGTGACGAAAG
+ATAAAAGAGAAACGATCATCGGGTTGTCCACGATAAAAAATTTCGGAATCCTGCAATCCG
+TCATTGAATTTCTGACGCAGGCGTTCCGCCTCTTCTCTGATGGCAGGAAAATCTTTCTCC
+GAATGTGCCAGAATGACCACACGAAAAGTTCCCATCGCATTGTCATACCAGCACTTCCTG
+GCTATTTCTGTTGAATTGAAAGGTATCCAAATCTGCGCATAAGAAGAAACAGCCAGTTTG
+GATACATCTTTCACAACACCCACTACCGTATAATCGGCCAAGTTGAGTTGGACCGTACGT
+CCTACCGCTTCTACCGTACCAAACAAATTCCGGGCCACAGAAGCACTAAGTACAACCTTA
+GGAAGTCCGCTTTCACTATCGGCAGCCGTAAACGGCTTTCCGGCAATAAAATCAAAAGAG
+AACACTTTCCAAAAGGTATCGTCAGTTTCAAGGTTATCCACTGTCATCATTTTTCCAGCA
+GGTACAGAAATACGCATCCTGCCTCCTGTAGACACTATAGTTACCGCCTCAGGAACAGTA
+AGTGCCTTAAAACACTCTTTAGCCACTGTGAGTGACATACAGCCGTTTGATGAATTATCA
+CTGGTATCTCCTTTCTGATGAATAGACATCGCTTTCATATAAAGAGAACGTGAACGGTTC
+ACCTCGGGCACACAATCCGTAATGCGTACTTCCAACACCAGGACAATGACCATGATCATA
+CAAATAGCCAATGCCGTTCCTATGATAGAAACCAAGCTGATGAGCCTATTCTCACGAAGT
+TGGTAAAAGCCTGTTTAATATATAGTTTTATCATGTTTGTGCTATGCTCTAAAACCTTTT
+AACAAAAAAGAGATTACTCATTATGCAATGCTTCCGCCGGCTGAACTTTCATAGCCTTAC
+GTGCGGGAATCCAAATGCCTACTACAATCATCAATGCAATCAAAATAAAGGAAATAAGAA
+CTGTTATTATGAAACGTCCACCTTCAATAGTAGTGCCATTCATCCAAGCATTCAATTCAC
+TATTTGCCAGATTCCAATCAATAAAAATCGCAGGAATTGTGGCCACCGCCAATAATATCA
+ATCCCTCTGCCAACTGACGGACAAAGATACTATGATCTGTTCCACCCAATGATTTCATCA
+ATGCAATCTCACCACGTCGTTGCTGAGTACGGAACCAGAAAGTACCTAGCAATCCCAAGA
+ATATATTCAACAACAAGAAACCCATTCCGAAAAGGTAACTGTTCCAGGCATTCGTATGTG
+ACTGCTGAAAGTTACGACGGATATCGGTAAAAGAACGCACATCCGCGATAAACACATTGC
+CCACGCGATACAGTTTCTCACTATCCGCTTTCAAACGGGCTATAAAATCGCGATCTTGAT
+CCTCTTTTACGCGTACACAAAACTCCGTGCCCAAATCATACCATTCTTCCGGCATAGGAG
+CCACCATGCAGTAACTGTTCCATGCCTCAAAATAATCCCCATAACGGACAACCTGCAAAG
+AAGCCGCTAAATTATATGTATTCGTTGTATCCCCGAACAAATAAAATTGTTTGTCTACCA
+ATGAAGTCAAATCACATCCATAGCGCCGTTTATAAAGATTATCTGAAGCTAAGAAATTCT
+TCGGATGTTTCAGCATCTCAGCCAGTTGTTCAGGGGTCTCCCCACGGGTGCCACGATAAC
+GGAACACACGGACAAAATCGGGAGACACCAATCTGCGTATAGTCCATCCCGGCGAACGTA
+ATGTATCATACACCACTGACGCACTGCTGTTACTGCCATTATACGGGTAAGAATTTTGTC
+CTAATCCGGCTGCCTCTATGTCCGGTCTATGCTGAAGACGACTTAGAAGTTCCTTGATAT
+CCTGCCGCTTTTCCTCGTCTGTCTGATTGGGAATAAAGTCTGGACTTTTGTCCGTAAGAC
+GTCCCATTTGCACCAAATAGCAATGAGAAATATCAAATCCCCGTGGTTCATTATAAATTG
+AGGTCTGTACATACATATAGTCCACAATATACCATAAAACGACACTTACCAACAATAATT
+CGGTGACAAGCCAAAGATTAGACCGCCATTCATTTTTTATCTGAGTAAATAGTTTCTTAT
+TCATCTTGATTCTTTACTTTTAATTCGTTATCACCTTAGTGAATCCTTCCTCCCAGTGCA
+TTGACAATGCTAGTCCTTGAAGCCCTCCAAGCAGGAATGCCGCTACTCAGCAAATTCAAA
+ACAAAGCAAAACAGCAATGCATAAAGGAAAGTGGAAGGGTGCAATAAAATACTGGAATCA
+ACTGTAGGGGCATTCAATGTCGCACTATAAGGCTGTGCAAACAGGATATCGGTACCTAAA
+TAAGCCATAACAATACTGATAAACAAACCTACGGCACCAGCCAACAAAGTCACGACCAGG
+TTTTCCATGATTATTTGTCCAACCATTTCCATGCGGGTGCTCCCAAAAGCACGGCGTACT
+CCTATTTCCGCCACACGTTGGCGCAACCGGCTTTGCGTCATACTGCTCAGATTTATAGCA
+GGTACTAACAACAGAATGATAAAAATGATAGCACGTTCACGACGAGCCGACTTCAAATCC
+GGCTCCAAGTTAGCTGCAAATGAAATAGACTGAGTTTCCTGATCGTATGGCCGGTTACGG
+TCTATCAACGTATACCCCTGATCGGCAAGAATAGAATTATACTCACTCATACGCCGCTTG
+GCTTCAGCACGGATTTCTCCAAAATCATCATGGCTTCGAGCCAAAATAGTGACACTCATC
+ATCCCCATGTGCTGGTCACTCCACGTATCATTAGGCAAATCCGTCGAAGTAAAGGGAATC
+CATACTTGGCCATAAGAAGCATCGGCAAGAGTAGATACATCTTTCACTACCCCTACCACA
+CGATAGGGAGCATGATTCAACAAAAACTCTTTGCCCGCAGATTCTGTGGAACCAAACAAA
+GCCCGCGATATGCTCTCAGTAATCACAGCCACAGGAGTGCCTGCATTGAAAGTAGCTTCA
+TCGTATGGTTTTCCATTCACAAAACGAAAATCGAACACTTTAAAAAAAGTATCATCCGTT
+TCCCGCACATCCGCTCCAATAGCCGGCATAGCGGGTAATGAAACAGGAGTCGATACCGGC
+ATACTGCAATAAATAGTGACAGCTTCAGGGGTTTTCAATGATTTATATATCTCACGCGCT
+GTCCGCACACTCATCGGTCCGTTACTTGTTCCGTCCCCCCAATCCTTATGACTAATACTC
+ATATAATGCACATGCAGAAAACGATCCCGGTTTGACTCGGGAGAAAAAGGAGCGACCTTC
+ACTTGTTGTAGCATCACTACCAACATAATAAGGAAAATGCTAAGAGCAGTTCCTGCAATG
+CTGATGACACTGATAAGCGGATGCTGGCGAAGTTGCGCCAAAGCTTGCTTAAAATACTGT
+TTAATCATCTCTGTTATTTCTTAATAAATTCCTTTTCATAGTAATCAGTAGTTATTGCAC
+CTGACGCCCATCAAAGAAACGAATGGTTCTGGAAGTCTGTTTGGCTTGTTCTTCATTATG
+GGTTACCATCACAATGGTCCGTCCATCCTCTTTATTTAATTTATGCAACAATTCCATGAC
+CTCTGCACCCATCTTTGAGTCCAGATTACCGGTAGGCTCATCCGCAAGAATAATTTCAGG
+ATTACCCACAATAGCACGGGCTATCGCTACACGCTGGCACTGTCCTCCGGAAAGCTGTGT
+GGGCATGTGCCGCATACGATGACTTAAACCGACACGATCCAACACTTCTTTTGCCAGACG
+GGTACGCTCCTTGGCAGCCATCTTTCTATAGAGCAAAGGCAACTCCACATTGTCAATCAC
+ATTCAGCGAATTAATCAGGTGGAACGACTGGAATACAAAGCCCAAGGTCTTGTTACGGAA
+AGCAGCCAGTTCCTTGTCCTTCATGCTTTCTACAGACGTGCCGTTTATTTCAATCTTTCC
+ACTGCTGGGAGCGTCCAGCAGCCCCATAATATTCAGCAAGGTAGACTTGCCGCAACCGGA
+AGGACCCATAATGCTGACAAACTCCCCTTTAGCCACATCCAAATTTACATTTTCCAGCGC
+TAATGTTTCAATCTCATTCGTACGGTAGATTTTATTGATACCGGTTAATTTAATCATTGC
+CATATTTTTTTCTTATTTAAATTGTTAATCTTATACACTTTCTATTTTCATGAATCAAAA
+GACATTCCAAAGCTATAATCATTTAATATTCAACGAATTTTAATTCTACATACTGTCCGA
+TAACAGACGGTGTGACCGTTTTTACCGGACTAATACGACTGATGCTGTATGCCGGAAAAA
+AATGTCAACAAGCACTATGAATAATATAAAAAGGTAAACGATCAAAAAAACGACATAGCC
+TAAGAACAAATTAAATTATGTTCGGGAAATGAGTGAAAAGGATGAAAAAACACTTCATTT
+CCCGTAACAATCAATGTATTAATTAAGAGAGAGTTTTATCTTGTTGTTTATGTCATAGCT
+GCTTCTTATTTCAACTTCAGCTTATTCTTGTTTTTGTAACTGCTCATATCGCTGACAACC
+ACCTTGTCACCCGGTTTCAACCCCGATATGACTTCCACATATTCAAAATTACTATCACCC
+AATTGAACCTTACGCTTTACTATTTCATCCTTACTATCCTGAACAAATAATTCATACTCA
+CCGCGACCGACATAGTAAGAAGCATTCGCCAATCTTAAAACCCCTTCTTTCACGGCATTC
+ATTACATATACATCCGTCTTCAAGCCGGAACGCAATCGCTTGTTATTATCTTCATTCAAT
+TGTACAATAAAGGAAATCACCCCATTCTTACTCAACGGTGTCACACTACTTACCGTTCCT
+TCCAGTTTCTCATTGCCAATCTTGACTATGGCACGTCCACCTGCTGCCACACGGTCACCG
+TATGTATCGGCTATTTCACCTTCCACTTTAAAGTGGCTCAAATCAGAAATGATAGCTACC
+TGGCTGCCTTCCGCTACCTGCGCACCTACCTGATTATTTATATAGGTAAGAATCGCTTTA
+CGCGGTGAACGAATTTGAGCGTCATCCAATGTACGTTTCATTTCAGCAAGACTCTTTGAG
+AAAATATTGAATTCCAATTCCTTCACTTTCAAATCAGCCTCTTTTACTTTCGATTCATTC
+GCGTATTGCTGACGGAGCTGTTCCAATTCCAATTTTCCGGTATTAAAGTTCAGTTCAGCC
+TGACGAACCTTGTCCGTTGTTCCAGAGCCCAAACTATCCAAATAACGTTCGTTACGAAGT
+TCCACCTCCATACGGTTCAATTTCATGGCGGAAATTTTCACTTGCATCGATAAATCACTC
+AGATACGTATTATTATTCACTTTCAACTGCTCTAACTGATAACGTTTCATCTGTTCTTCA
+TCCAGTAATTTCTTGTATTCAGTTTCCGTACTCTGCAAATCAAGTTTCAAAATCGGCGTA
+CCTACATCCACACTGTCTCCTCCCTTACGGTAAACTTCCACGATACGAGTATTAATAGGT
+GAGTTGATAATCTCTTCAAAAGCCGGAACAACCTTACCGGAAGCACTGACACTTACTTCA
+ATAGTTCCATTGTCCACTTCTGAAAACACCAAATCTTTCCTATTGACGCTGCTTCGCATA
+AACGAAATCAATACAGCTATACATACCACTGCCGCCACACCTATTGCACCATATTTAATG
+AACTTCTTTTTGCGCTCCTTATCACGCACTTCTTTAGGAATTTCTCTGTCCATAACTTAT
+TGTAATTTTATTATTATCATTTTTGTGCTAAAGAATAAACAACATCCGTGCCAAGGAAAC
+AACTTATTGATAATCAATAACAAATAAAGCGTACAAGGTGTCCGATATCGGACACCCTGT
+ACGCTTTTAAACATCAGTTACCGTACAATAATGATTAACGCAAACGCAATATATCACCTA
+CTTTAGGAGAAGGGTCTTCCGGTTTCATCTTATTCATCTTATATAAATTTTTCAGACGAA
+TACCATATTTTTGGGAAATGGAATACATAGATTCTCCCCCACGGACAACATGAACTATGT
+GTTCCTTATCCGCACGACGATGCTTTTTATCCAAATAAATAATATCACCTGGCTTCAATA
+CATATCCCTTATAAAGATCATTGTATTTCCTCAACTTGCGTTGACTGATATCAAATTCTT
+TAGAAAGTTTTTTAAATGTATCCCCCGGACGTACCACAATATAGAGTAAATCATTAGCCA
+AATAAGGCTGATGCGGGTTTGGGAATTCCTTCATCCACTTTATACCATCCTTGGTATCAT
+ACTTATGTAATTCATATAATTCAATGATATCAATTAAACGATATGCATAGCGAGGGTCAG
+TAGCATATCCCGCTTTCTTCAGCCCATGCGCCCATCCTTTATAATCGGTGATTTTTAATT
+TAAAAAGAGATGCATAACGTGAACGTCCTTTTAAAAATTTAGAATGATCTTCATATGAAT
+CACGAGGGTGCTTATAGGCACGAAAACATTCATTACGGGCATCATCATCATGCCGTACAG
+TACGACCAGTCCAGTCACCACCACATTTTATACCGAAATGATTATTGGATTTACGAGCCA
+GTGTACTTTTTCCCGCTCCTGATTCCAATAATCCTTGAGCCAGAGTGATGCTGGCAGGAA
+TACGATACCGTTTCATCTCATCGATAGCGAGATCTTTATACTTATGAATATATTCCTCAT
+ACTGCCGGTTACGGGTTTGCGCTTGCACTGTAAAATTACATAGACAACAAAACAACCCGA
+TTAATATAAATTTCAACGTATGTTTCATCATATAAAACTGTTTCAAAATCGCGACTATAC
+TTTTTCCGCTATATATAGTTGCAAACTTACCATTTTTATCCGGCTGTATGCAATCTTTTT
+AAATTAATTACGAATTTCATTCGAATTCCAAAAGTCCAAAGAAATCCGGACGATGAAAAT
+CCGGCTTCTCTATTTTAATAGGATTCCATGATAAGAAATGAGGCTTTTGCAATTCATCTC
+CACATTTATAAAAATTAGCCCGTATGCTCATTCCATCCAGCCCGGTAATGGCATGCTTAA
+AAAATACCTTATACGGAATCAGCAAAGCCACCTCCCAAGTACATTCTCCTATCTTTTCTT
+CAAAAGTTTCTCTGCCCAAGCTAGCCCAACGCTTCACCTGATCCGTTATTTCAGAAGGAG
+CCATTTCACGATTATTACGCTCCGAACCTGCTGCTAAAAGAATCGTAGCGATACAGTTAC
+ATTCCAAATTATAATAAATGCCATCTCCCGCAGGAATAGAGAAAAATTCCACGCAGGAAT
+CTGTCCAAACACTACCGTTATCTTCACCGTATTTGGCACGAACACTGTCTTCTACTACTT
+TATAATGGACTAATATAGCATCATTTGTATAGGCTATACGAAAAGAGACTTGAGGTTGAT
+AAGGATATTCTTTCCAGTTCACTATATTAATAGGATGATACGTAATGTTCTCATTATCAA
+ACAAGGTCGGTATTTGTCGTGCATCTTGAACTTTACCACTTAATTTCTTTACTTTCATCG
+TATTGTTTTTATTAGTTAAATAGCTACTATTAGCTTCACAAAAATATATACTTCCACTGA
+GAAAACAAAATAGTGGCTACCATAAACAGCAGCCACTAAAAGAATAAAGCAATAAAGACA
+ATGAAAGCACAATTTTTACATTTTCATCCATATTTATTTCTTCACATCGCCCTGTGGCAT
+ATGTCTTCTCCCATCATGCTGCTTTTTCATTCCTTGTCTTTTTCTCATCTCTTTACGGAA
+TTTATCGCCATTGTGTTTCTCCATATTATACATTTTCTGAATTTGTTTAGGAGAAAGAAA
+TTTCCGGAACTCATTATAATACTTCTCACGAACATCCAGTATCTTTCTACTCTGCGCGAA
+ACGTGCCTTGATAGCCTGCTCCACTTCAGCATCTGTAGGAAGCGGTTTGGGGGTCTGTTT
+ATCTGCAGCCGTTCTATTTGCAATATTTCGACAGGCTCCCATATGACGAGTAGCCCGCAT
+TTCTTCCATGTATTGTTTATACACCGGAATAAATTTAGCAGTCGTTGCGTCATCCAATGC
+CAATCCTTTTATAATTTGATTGCACTGTATTTCCAGCATCTGCTCTTTATTAAACTGCCT
+TCTTTCAGATTTAGCTCCTTTCTTTTCTTGTGCAAAAAGTGTTACCTGACTTCCCATAAC
+AATGGCTGCCAACATCATTAAAAAAAATTTTGTTCTCATCATTTTTTTGTTTTTAGTGAT
+TAATCAATTTATAAATATATCATTTTCAGACAATTCCACCCATCCTGCTAATTCCTCATC
+AGACATAGATTCTATATAACGATCCAAAGTATCTGAATAAGAAGAGTCTAAATCCGTAGA
+AACAATAAGTGAATGAGAAGGCAACTCCTCTGCCACAGGTTGGGATATCGGAAAGAAAAG
+AACTCCCAACATGACAGCCGCAATAGCTAAAGCAGCCCCAATAATCAATTTTATTCTATG
+CTGCCTATTAAACCTCTCAGCCTGTGTACGCTCCAATACTTGCTTCTGCATTTTTCCGAA
+AAAGCCATCAGGGGTACGATAAGGCATCCGCTTCCCAATATTCTTAAAATCAAACTCCTT
+TTCCATCCTGTCTTTAATTATTTATCATGTACTCTTTTATCTTCTCTTTTGCATAATGAT
+AATTCACTTTCAACGTATCCACTTTCGTGTCCGTAATCCTGCTAATTTCCTCATATTCCA
+GTTCATCATAATAACGAAGATTGAAAACTACCCGCTGCTTTTCAGGAAGCATCAAAATAG
+CCTGCTGAAATTTCACCGCCATTTCGTTCTCATAATCCACATAATCTGACGCCATCAACT
+TATTCATTAACTCTTCCTGAACTTCTTCCGCCGAAACAGCTTGTTCCTTACGCATATTCA
+GAAAACGGAAACACTCATTGGTCGCTATCCGGTAAATCCATGTTCCCAATGAACTTTCCT
+CCCTAAACTGAGGAAGATGGCGAAAGACGCGAATAAAGACTTCCTGCAGAATATCCTCTG
+CATCCTCATGTGATACAACCAATCTCCGGATATGCCAATATATGGGCTGTTGAAAAAAAT
+CTATCAACAGTTTAAATCCCCGTTCCGGGTTGGAAGCCCATACTTCCCTAATTTTATCTT
+CGTTTATCATCTATTCGTCAAAAGTTTATAGGTTAGAACCACCCGAGAACAAGAAGTTAA
+AAGTGAAAATGAAGTTTTTACATTAATTATAGATGAAGTTAAAATAATCAATCACATTTC
+CTACAAGAGAAAAATACAACCAATCTTCCGGAATATGAATTTAAAGAATTCAAACTCAAT
+CTTCCTATCAATAAATTTCAGTTCTTAGAAGAATTACCATATAAACAATAGGGAAATCCC
+TAAAAATAAATAGGGGAAAAGATAGAAGAATATACCTTTTCCCAACTTATCTTTGTTACA
+AACAAAAAAACAAAAAAATGAGAAAATTGAAACAAACATTATTAGCGTTAACCATTTGTA
+CTTTAGTCATCAGTTGCAGTTTGACTACTAGTAGCACTATTATGAAAGTACAGAGAGGGA
+TGTCCCAAGAAGAAGTCAGCCATTTACTTGGGAAACCCGATTTCCGTAGATTCGACAACG
+GCTCGGAACAATGGGAATATACCAAGACCAATGTGTCCACAGCTGCAAACACGGTAATTA
+TTATCGATTTTGTAGACGGAATGGTAACAAACATGGATTCTTTTGAGTCCAACATTACTC
+CGCCTCCAGTTGCAGTGTGTCCGCCAAATGAAATCATTACGGTAGTTCCACCCAACCACC
+CTGATCATTCTGGCCCGCACAGACCAAAACACAAAGCCATGAATCCACATGATTTTGAAA
+ACCTCTACAAAAAAGTAAAAAACAAAGCATTTAAGGACGACCAAATGGAATTATTATCTG
+TAGGAGTTGTAAACAACTACTTCACCTGTAAACAAACTGCCCGACTCATGTCCATATTTA
+CATGGGACGATGAAAAAATGAAAGTATTAAGAATGGTTTCCAACCGCATTGTAGACCGTG
+AAAATGGAAAAGAAATCATCAAGACACTGGATTCTTTATTTAAACAAGATGATGCACGTA
+AAATATTGGGAATCACTAACCAATGGTAATTCAACCTAAACAACACACAAAAACATAAAT
+ATATGAGAAAATTCAAACAACTATTATTGCTTGTTATCAGTATAACACTTGTCAGCTGTC
+ATACCACAGGAAGTATCAAACAGAAAGCATGGAAAGTACAGCAGGGAATGACAACAGAAG
+AAATAGGCCAACTTCTTGGAAAACCCGATTTCCGACGTTTCGATGGTTCTTTGGAACAAT
+GGGAATATCAGAGCGGAGGAATTGCAACGTCTTGCAAATTTCTAATTATCGAATTTCGAA
+ACGGAAAGGTAACAAGCATGGATTCCTACAATGAAATAGCTAAAGAGACTTCAGTAGGAG
+ACCTATATTCCAGCAAAATATCCCTCCATACCGTTGGTTCAATAGACGATAACGAATTTG
+AAAAGATATACAATGAAACAAAAAATTCCGTATTCAAAGATTCAACTCTGGAAAAAGCCA
+TTATAAATAAAAAATTAAGTTGCGCACAATGCCTTAAACTTATGTCACTTTATACTTTTG
+ATAATGACAAGTTAAAAATGTTACAAGTACTGAAAGACCATATAGCTGACACAACAAATT
+ACGATAATATTGTCAACTCACTAGATTTCATTTCAAGTAAAAACAAGGCCAAAGAGATAT
+TAGGAATACCCTAATACAGTAAAAGCAAACGTACCTGTTGCAATAAACCTAAAAAATATT
+GCAACAGGCACATCTGCTTTACCTCAATCTTCTATTCTGACAGCTGTGCCGCTTGCGGTT
+ACCATCAGCATACTACCACTGTCCCCCACAGTTTCATAATCCAAATCCACCCCAACTACA
+GCATTAGCTCCCAATAAAGCAGCCTGATCCTGCATTTCTCGTAACGCAGTATCTTTAGCC
+TGTCGAAGTACTTCTTCATAAGAACCGGAACGACCGCCTACAATGTCACGAATACTAGCA
+AAAAAATCACGAAACAGATTAGCACCGATAATAGTTTCACCTGTTACAATGCCATAATAT
+TTGGTTATACGTTTTCCTTCGATAGTAGGTGTTGTTGTTGCTAACATAATCTTTCTCTTT
+TTTAATTATATATTCATTAGACGCACAAATAAAAGAAAAAGTTGCAACTTTCTCCTTTTT
+TATCGGTAACTATATTATTCTTTTCACATTCAACTCTGACAAGCAATAAGAAAACAAATA
+AATTTAAAACCAGATTTTAGAAAAGAAACATTGGGAGATTAAAAACAAAACATTACATTT
+GCAAGAAAACAAAGAGGAACGTATCATGAAACAAATCAAACTGGAAATAAACATAGAGGC
+TTGCCATTATGACGAACTAACAGAGAAGGACCGCAAACTGATAGACGCCGCGTGTGAAGC
+AACGAAAAGAAGCTATGCTCCTTACTCACATTTTGCTGTTGGAGCCGCCGCACTGTTGGA
+AAATGATATCGTCATTACCGGAACCAATCAAGAAAATGCAGCCTACCCATCTGGTCTTTG
+TGCAGAACGTACCACTTTGTTTTATGCCAATTCTCAATATCCGGATCAAGCAGTAAAAAC
+ACTCGCCATTGCTGCCCGCACAGAAAATGGTTTTCTTGACACACCTATTCCTCCTTGCGG
+AGCCTGTCGGCAAGTATTATTAGAAACTGAAAAACGATATGGAAAACCTATGCGGATACT
+GCTTTATAGTAAGACTGATATTTATATATTAGAAAACGTAAGCGGACTTTTACCTTTATC
+GTTTGATGGAAATTATCTGAAATGATACCTACCATCCGTCTGCACAGCCAACAGTTAATA
+AATCCGGTTTTCAATAATCCGAAAGATCTTGTATCATGGATGGGAGGCATTCAAGCGCAA
+GATTACACCATGTCCAAATGGGCTATTGGTATCCGGCTAAAGGCAGGAAATCTGCAAACA
+GTCAATGAGGCACTGGCAAAAGGAGATATATTGCGCATTCATGTCATGCGTCCTACTTGG
+CATTATGTAGCTGCAGAAGATATACGCTGGATGCTGAAGCTTTCATCCCGACGCATCATT
+ACTGCCAATGACTCTTTTGCCAAGTCCAGAGGACAAGACATTTCAGTTGACATTTACAAC
+AAAGCAAACCGATTATTGGAAAAGGCACTAGCAGGACACAATCATCTGACCAAGCAAGAA
+ATTGACAACGTATTTAAAGAAGGAGGGCTGGAAACCAATGAAAGATTATCCAACCGTTTC
+CTGATTCACGCTGAAGCTGAAGGACTTATTTGCAGCGGAGCAGATAAAAATAATAAAATC
+ACCTTCGCACTTTTGGATGAGCGTGTTCCTCCAATACAAGAATTACATAAAGAAGAGGCG
+CTAGCTATCTTGGCACGCAAGTATTTTAGAAGCCACTCTCCTGCCAGTCTGAAAGACTTT
+GTATGGTGGTCCGGACTTTCGGTAACGGAAGCTAGACAAGGTATAGCCGCCATTGAACAA
+GAATTGCTTACTGACCGTTTCCTAGCACAAAAATTATATGTTCATCAGTCTTATAAAGAA
+GAAAAAACAACCGACATATTGCATATCCTTCCTTCATACGATGAATACCTAATCAGCTAC
+AAAGACCGTACTGATGTATTGAACAAAGAATACCAACACAAAGCATTCAATTCTTTCGGG
+ATATTCCGTCCGGTTATTCTGTACAACGGGCAAATAGTTGGAAATTGGAATAAAGTCATA
+CAAAAACAAACAACACATATAGAAATGAACTGGTTCAAGAAAAATACAAAAATCAGGTAC
+TGTCCAAAATTTTGTGTAAATGGAAACAGGATTCAGTTGTAAGTTTGTTCTTATATCTGG
+ATTCTGTTTTCAAATATAAGCATAAACTGGTTCATAATCAATCCCCAGTTTGAAATAGGC
+ATTGTCCATTTCTTTTCAATCTCCATAAGTGAAAGATACACGGTCTTTTTTACGGCATCG
+TCCGACGGGAATGAAAGCTTTGATTTGGTGTACTTTCTGATTTTTCCGTTCAGATTCTCA
+ATAAGATTTGTGGTATAGATTATTTTCCTGATTTCCAATGGGAACTGGAAGAAAACAGTC
+AGATCATCCCAGTTGTTTCTCCATGAAAGTATGGCGTATGGATACTTTCCTCCCCATTTC
+TTTTCCAGATTGTCAAGTTCTGCGGCAGCAACTTCCTTATTAGGTGCATTGTAGATATTC
+TTCATATCCGCCGTAAACTCTTTCTTATCCTTATAAACGACATATTTACAGGAGTTCCTG
+ATCTGATGTACCACACAGATCTGAGTGGATGACTGGGGGAATACGGTACGGATGGTATCT
+GTAAATCCATTCAGATTGTCAGTACAGGTAATCAGTATATCCTGCACTCCACGAGCCTTC
+AAGTCGGTCAGGACACCCATCCAGAAAGAGGAACTTTCCGATTTGCCGACCCACATGCCA
+AGGACTTCCTTCAGGCCGTTCTGTTTCAGACCGACACAAAGATAGACGGTCTTGTTTATA
+ATCTTGCCGTTATCCCGTACCTTGAAGACGATACCATCCATCCAGACTATCAGATAGACC
+GGATCCAGAGGACGGTTCTGCCATTCCTGCGCAGCCTGGCTTACCTTGTTTGTAATAATG
+GAAATAGCTGATGTAGAGAGCTCTATTTCATAAATCTCACGCATCTCCTCCTCTATATCG
+GAAACACTCATTCCTTTGGCATACAGGGAGATAACAAGCTTCTCTATAGAAAGTCCCCGG
+CTTTCATGCTTGGGGACTGCTATCGGTTCAAACTGCCCGTTGCGGTCACGCGGAATGGAG
+ATGACAGACTCTCCATGTCCGGTCTGAATTTTCTTCGGATAACTGCCATTCCGGGAGTTG
+CCGGTGTTGTTCCCTGCCACGGAATTCTTCTCATACCCCAAATGGGCATCCATCTCACCT
+TCAAGCATCTTTTCCAATACCTGCGCATGCAACTGATTCAGAAACCTGCTCACATCCGCT
+TCTGTCTTGAACTGGCTAAGGAACTCCTTGCTTAATACCTCATCAGGCACTACTTGATTC
+TTTTCTTTCATAATCTTTTTCATTTGGTAAATGTATAAAATAAAAAATACGGAACTCGAT
+TTTGAATCCCGTATTTTCCATTTACACAAAATATTTTATAGTGCCAAAAATCAAAAAAGA
+ATTACTTTCCCTAGCGGAGAGAAAATACCTTACTTTTTTCTCCGAACTGTAAGAAAATTG
+TAAATGGATTATTTCTGCGTCATCACATTTTAAAAATAATCCATTACATTTACATTATTC
+AGTATTGCAATATAAAACTCTCAGCCACTTTCAAGAAACGTTCATGACCTTTTTCATTCA
+AATGTGCAGTATCTGTATTATTCTTGCTGTTCTGAAAATATATTTTCCTAAAATGATCAT
+TACTTGCATAAATTCCTCCTTTTCGGGCGCTGTCAAAAATAGGAATACTATAATTTCCAC
+AAACCTCAATCATAGCATCCACCACTTTCTCAGCATCACTTCCTGCAAAATTTTTACAGT
+TCCATCGGGTAAAGAAAAAAATCTTAGCTGTGGGATACTTTTCAATAAGCCCTTCACATA
+GCATTGCCAGCCTCTCTTTAAATACATCAATACCGCCAATTGAATCCAATTTAAAACCAT
+CATTGTGCCCACCCACAACAATAACATAATCCAAATCATCCGGCATTTCCTTATATCTTA
+CATACATCGCTTCCCCCCAACGCGGGCTACTATAAGCAATGCTGCTGCCGTTCTTGCCAT
+AATTTAAATATTCCATACCATGTTTCTCGGCAAATTTATAATGCCAGGTATTCTTAACAG
+GTTCCTTATGATTCTTCACATAACTATCTCCAATAATTCCCAAACGTTTTCCTTTCAATT
+CATCAGTCCTGACGGTAACTCCTTTAATAATTTGTTCCAACTGCTTATATACCTGTTGTC
+CCAAATACTCTGCCGAATGAGCCGTGAAATGAAGTCTGTCATTTAACAATTCCGCGCCTG
+ACATATCTATCAGGTGCATGTTCGGATCTTCAGCAGCCAATTGCTTCATCGCATTCTCCA
+CTTCTCTGCTGAAATATTTATTACTTCGGGCAACAGTACCAAAAATAAAAGGCAAACGAG
+AATAATCCTTTCCGGTTTTTTCTGTCAGATGCATACGCACATAAGCCACCATTGTCTTCA
+AGTTACGGTAATAATCTTTACTTTTAGCATAATCACTTTCCCCCTGATGCCAAAGAAATG
+CATCTATCTGATAGCCATCCTTCAGGCGGGAAAGAGTCTTGTCTATACACATGTCTATCT
+CTTGAATGAAAGAAAGCAACAAGGAGTTTCCTCCATCAGAAGTTGGCTTAGCCTGTGCCA
+GCCATTCAGGCGCCGCAGACCAAAAACGTCCCTTGGAAGCATTATAATCAGGTGCTATAG
+AAGTTCCGCCAACAGCCCATTTCACCACATAAAATTTCTCCTGCAACAACTGCTCCAACC
+AATAATATGTCACTGCATCAAAAGCCCACATATTATTTTTTCCGCTACGTTTGGCACGAG
+GCCAGAAAGGAATAAATTCTCCCTTTCCGTCATTCTGAGCTATCTGACAATAACGGTAGG
+CACCTTCGGCATACGTCAGTGTATCCGTAGCCAATGCTTTAATATATGCCGGCAAATCTT
+CATTAGGAGTTCGTCCATCGGTATTAGACTGTCCGGCAGTTATAATCACATGTACAGGAT
+TGGAAGCCATCGTATTCAAGCCAACAGCTGCAAAAATCAAAATCAAAATTAAGTTTTTCA
+TAAGTATCATTTCATGTTTTTAATGGACACAAAAATAATCCTAATTCTAATATAACGACA
+TGGATTATCGTCCATTATCATAGATTTTTGAACTCATTATGGTTCATACAGAATGAGAAT
+TGCGGCTAAACCATAAAAAAAGAGCCACAGGAACAATGGCTCCCAATGACTCTTTCTTTT
+TCAGCTCATATTTATAATTTAATTATCTCCATACATACGCGCACGCATTTCTTTAATATG
+ATCAGAAGTGATGTATTCATCGTATTCCATCATCTTGTCAATGATACCATTCGGGGTCAA
+TTCAATAATACGGTTCGCCACCGTTTCAATAAATTCGTGGTCGTGGGAAGAGAACAGCAC
+ATTTCCCTTATAAGTCTTCAGATTATTATTGAAAGCCTGAATTGATTCCAAGTCCAAATG
+GTTGGTTGGAGTATCCAAAATCAGACAGTTCGCATTACGCAACTGCATACGGGCAATCAT
+ACAACGCATCTTCTCACCTCCGGAAAGCACATTCACTTTCTTCAATACTTCCTCTCCGGA
+AAACAACATACGCCCCAAGAAACCTTTCATATAGACTTCGTTACCTTCGCCAAACTGGCT
+CAGCCAATCTACCAAATTCAAATCACTTTCAAAGAAATCCGTATTATCCAAAGGCAAATA
+AGCCGTAGTAATAGTAACGCCCCACGCGAATTTACCAGCCTGCGGAGTACGATTTCCATT
+GATTATTTCAAAAAAAGCAGTCATGGCACGCGGATCACGGCTCAAAAAGACAATCTTATC
+TCCTTTTTCTACATTAAAATTCACATCATTGAACAATACCATACCGTCTTCAGTTTCCGC
+ACGCAAGCCGGATACTTCCAAAATCTGATTGCCCGGTTCACGATCCGGAGTAAAGATGAT
+ACCGGGATATTTACGGGACGACGGCTTAATTTCATCTACATTCAGTTTTTCCAACATCTT
+CTTTCGGCTGGTTGTCTGCTTGCTCTTAGCCACATTGGCACTAAAACGACGGATAAATTC
+TTCCAACTCTTTCTTCTTCTCTTCAGCTTTAGCCTTCTGGTTCTGCTGCTGGCGAAGTGC
+CAACTGACTTGATTCATACCAGAAGCTATAGTTACCGGCAAACATATTCACTTTACCGAA
+ATCAATATCTACAGTATGAGTACAAACAGAGTCCAAAAAGTGACGGTCATGACTTACCAC
+CAACACCGTGTGTTCGAAATTAGAAAGATATTCCTCCAACCAAGTCACCGTATCCATATC
+CAAATCATTGGTAGGTTCATCCAACAACAAGTTGTCAGGATTACCGTAAAGTGCCTGCGC
+CAACATGACACGCACCTTTTCCTTACCACTCAGTTCCCCCATCAACATATAGTGCTTGTC
+TTCCTTTATGCCCAATCCGCTCAACAAAGAAGCAGCATCACTCTCGGCATTCCAACCATC
+CAGTTCGGCAAACTTCTCTTCCAATTCAGAAACTTTCAAGCCATCTTCATCTGTAAAATC
+AGTTTTCGCATACAGTTCTTCACGCTGTTTCATAATGTTCCACAACACAGTATGTCCCAT
+CATAACCGTATCCATGACTGTATATTCATCCCACTTAAAGTGATCCTGGCTCAATACAGA
+CAGACGTTCGCCCGGTCCTAATACCACTGAGCCCTTAGTCGGTTCCAGCTCACCTGAAAT
+TGCTTTCAAGAAAGTAGATTTTCCGGCGCCGTTCGCACCGATAACCCCGTAAATATTACC
+ATTGGTGAACTTCATATTTACGTCATTATACAACACTCTTTTACCAAATTGAATGGCCAA
+GTTCGAAACTGTAATCATCCTAATATACCTTATTTATATAATTATTCTATTTTGGAATTG
+CAAAGGTAGGCATTTTAATTCAGAAAAGTATGCCAGTGTGGCAGAAATTCCGTACTTTTG
+CAAAATTATTACTCTAAGAAAACAACTAGGCACGAAATTTGTTAGCAGTAAATTAACCTA
+AAAGACCTGACTGTTATGAGTAAAAATAAGAAAAACAAAAAGTTTAATAAGAATATGAAC
+CCAACAGAGAAGAACCAACCTCAAGACGAGGAAGTTTTGAAAAATCAGGAAGCGGCAGAA
+GCTGCCATTGATGAAGAAACTCAGAAAGAAGCAACAGAAGAACTGAACGCTGAAGAGAAG
+GTGAACAAGGAATTGGCGGAAGCTCAGAAAACAATAGAAGAGCAGCATGACAAATACCTG
+CGTCTTTCAGCCGAATTTGACAATTACCGTAAACGCACCATGAAAGAGAAGGCCGAATTG
+ATTAAGAATGGTGGAGAAAAGGCCATTACTGCCATTCTTCCTATTTTGGATGACTTGGAG
+CGTGCAGTAAAGACTTCAGAAACTTCGGATGATGTAAAAGCAATGCGTGAAGGAATTGAG
+TTGATCTACAACAAATTCCTGAAAGTATTGAACCAGGAAGGACTTCAGAAAATAGAGACT
+GACGGTGAGAACTTTGATACCGATTATCACGAAGCAATTGCATTAGTTCCAGCTCCTTCC
+GAAGAGAAGAAAGGAAAAATATTGGACTGTGTACAAACCGGTTATAAGCTGAATGACAAA
+GTAATACGCCACGCCAAAGTAGTTGTGGCTCAATAAAACAGTATCATAAAACGACATGGC
+AAAAAGAGACTATTACGAAGTTCTGGAGGTGGACAAAACAGCCACCCTTGATGTTATAAA
+AAAAGCATACCGCAAAAAAGCAATACAATATCATCCGGACAAGAATCCGGGAGATAAAGA
+AGCGGAAGAAAAATTCAAGGAAGCTGCCGAAGCTTATGATGTGTTGAGCAACCCGGATAA
+ACGCGCCCGTTACGACCAATTCGGACATGCAGGAATGAGTGGAGCTGCCGGTGGCGGTTT
+TGAAGGATTCGGACAAGGTATGTCCATGGATGATATTTTCTCTATGTTCGGTGACATCTT
+CGGTGGACATGGAGGAGGTTTCGGAGGCTTTGGAGGTTTCGGTGGTGGCGGACGTTCCGC
+ACAACGCAAGTTCCGTGGTTCAGACCTCCGTGTAAAAGTAAAACTGAACTTAAAAGAGAT
+TTCTACGGGAGTAGAAAAGAAATTCAAACTGAAAAAGTACGTAACATGTGACCATTGCCA
+TGGTTCAGGAGCCGAAGGAGAAGGAGGAACGGAAACGTGTCCCACTTGTCATGGAACAGG
+AAGTATCACCCGCACCCAACAAAGCATTTTTGGAATGGTGCAATCACAAAGCGTATGTCC
+ACAATGTAACGGAGAAGGGAAAATAATTAAGAACAAATGTAAAGCTTGTGCAGGAGAAGG
+TATTGTATACGGAGAAGAAGTCGTGGAAGTGAAAATTCCTGCCGGTGTGGCTGAAGGAAT
+GCAACTTTCTGTCAATGGGAAAGGAAATGCGGGCAAACATAACGGTGTTCCCGGTGATTT
+GCTTGTTGTCATAGAAGAAGAATCCCATCCAGACCTAATACGCGATGAAAATGATTTGAT
+TTACAATCTGTTACTAAGCGTTCCGACTGCTGCTTTAGGAGGCACTGTAGAAATACCAAC
+TATTGATAGCAAAGTAAAAGTAAAAATTGAACCAGGCACCCAACCAGGTAAGGTCTTACG
+CCTAAGAGGTAAAGGATTGCCCAATGTCAATAGTTATGGTTACAGTAACGGTACAGGTGA
+TTTATTAGTCAATGTAAGCGTATATATTCCAGAAACGTTGAATAAAGATGAAAAACAAGC
+ACTAGAGAAAATGCAAGAATCGGATAACTTCAAACCGAATACAAGCATTAAAGAAAAAAT
+ATTCAAGAAGTTCAAAAACTTCTTCGATTAATTTTTATACTACAAAGTGTCACAGAAAGA
+ATACCAGGTTTTATATCTGCCTGGCATTCTTTTGTGACACTTTGCGGTAAATAAAAACAT
+TTGCCATGAATTACGAAGAAACATTGGATTATTTATATAATAGTGCCCCATTATTCCAAC
+ATATAGGAAAAGATGCATACAAGGCAGGATTAGAAAACACTTATCTTTTAGACAAGTATT
+TCAACCATCCCCATCGCCAATTCCGAACCATTCATATAGCCGGGACCAATGGAAAAGGCT
+CTTGTTCACATACTTTAGCCGCCATTTTACAATCAGCCGGATACAAGACAGGACTTTACA
+CTTCTCCACATCTGATAGATTTCCGTGAACGAATCCGCGTCAACGGAATTCCTGTATCCA
+AAGAATATGTCATAGACTTTGTAGAAAAACACCGTGCCTTTTTTGAACCTCTGCATCCTT
+CTTTCTTTGAACTGACTACCGCAATGGCTTTCCACTATTTTGCCCAAAGCCAAGTAGATG
+TAGCCATTATAGAAGTCGGCCTGGGAGGACGAATAGATTGTACAAACATCATCCGTCCGG
+ATCTATGTGTCATAACCAATATCAGTTTCGACCATATACAATTCTTAGGTAACACATTAG
+CCAAAATAGCCACAGAGAAGGCCGGAATCATCAAAGAAAAGACCCCGGTAGTTATCGGTG
+AAACCACACCCGAAACCAAACCTATATTTACAACCCGTGCTAAAGAAGTAAACGCTCCTA
+TCTACTTTGCAGAAGAAGAACAGTTATTACACTCCTCCAGCATAAATGAAAAAGGTAAAC
+GAATATATCAAACAACCGACTACCTCAATCTGGAAGGCGAACTGGAAGGGCTTTGCCAAC
+TTAAAAACACCAATACACTTTTATCTGCCATCCGCCTATTAAAACAAGCAGGTTATCAAC
+TTACCGAAAGCAATATACGCAAAGGATTCTCACAAGTATGTGAACTCACCGGCCTGATGG
+GAAGATGGCAAAAATTAGAAAGTGAACCGACTTTAATATGCGATACAGGACATAATGTAG
+GAGGTATTTCGTATATCATAGAACAATTAAAACATCAGAAATATGAACGATTACACATTG
+TAATAGGTATGGTAAACGACAAGGATATCAGTGGAGTATTGTCCATGCTTCCTAAAAATG
+CCACCTATTATTTTACCAAAGCCAGCGTAAAGCGTGCTTTATCCGAAAAAGAATTACAAA
+GCTTAGCGATGCAATCCGGGCTGCACGGAGATACTTATCCTGATGTAGAAACAGCTGTAA
+CAGCCGCTAAAGAAAAGGCTAACAAAAATGACTTTATTTTTGTTGGAGGAAGCAGCTTTA
+TCGTTGCGGATTTATTAAAATTTCACGTTTAGTCCGTTCACTTTTATAGAAAAAGTTTGG
+GAATACCGAAGAAAATCTTTTTATTTGCATTAGTTTTATACATAAAATAAAAAGATTTTC
+AATAACATGATAAACACATCTACTTCCGATGAGAATTTATGCGGCCTGAAACGGGCCGAT
+TTTCAGACAACAGTGAACGGGAAACAAACAGACCTCTTCATTCTGAAAAATGAAAACGGA
+GCTGAAATAGCTGTCACCAACTATGGTGGAGCAGTATTAGCTATTATGGTTCCGGACAAA
+AACGGTAAATATGCCAATGTCATTCAAGGACATGATAGTATAACCCATGTTATCAATAGC
+CACGAACCTTTCCTCAGTACTCTTATCGGTCGTTACGGAAACCGTATAGCAGGAGGCAAA
+TTCATTTTAGAAGGGAAAGAATATTCACTGACTATCAACAATGGTCCCAACTCGCTGCAT
+GGCGGTCCTACCGGATTTCATACCCGCATTTGGGATGCAGAACAGGAAACTCCCCAAAGC
+TTGAAATTGCATTATTTATCTGCTGATGGCGAAGAAGGATTTCCGGGAAATTTGGATATT
+CACGTAACGTACACTTTAAGTAATCAAAATGAATTCATCATTACTTACCACGCTACAACA
+GACAAAACAACATTGGTAAATCTTACTCACCACGGTTTTTTCAGCCTATCAGGCATTGCC
+AATCCTACGGCAACCGTTGATAACAACATCGTAACCATTAATGCTGATTTTTATACTCCG
+ATAGATAATGTATCCATCCCTACAGGCGAAATTGCCAAAGTAGAAGGTACTCCTATGGAT
+TTTCGTACTCCTCAAAGAGTAGACAGTAGAATCAATGACCCATTCGAACAGCTAGAATTC
+GGTGCCGGATATGACCACTGCTATGTATTAAACAAACGTGAAGCAGGCACACTGAGTTTT
+GCAGCAAAATGTGTGGAGCCCGAAAGCGGTCGTAGCATGGAAGTATACACTACAGAGCCC
+GGTGTACAAGTTTATACTTCAAACTGGCACAATGGTTTCGAAGGTGCTCATGGAGCAACT
+TTCCCAGCAAGAAGTGCCATCTGTTTTGAAGCACAACATTTTCCTGATACGCCCAATAAA
+GGCCATTTCCCTTCTTGTGTTCTACATCCGGGGGAAACTTACAATCAAGTAACCATCTAC
+AAATTCGGTGTAGAAAAATAATTTTATGAAATAACCTAATTAATAAACTTATAATTTTTT
+CAAAACCATGAATCAACAAAAACAGAACGGTAATATCATCGCTATCATTACAATGTTCTT
+CCTTTTCGCGATGATTTCCTTCGTTACTAATCTTGCTGCGCCTTTCGGCACAATATGGAA
+AAACCAATATGCAGGTGCCAATACCTTGGGTATGATGGGAAATATGATGAATTTCCTCGC
+ATATCTGTTTATGGGGATTCCTTCAGGTAATATGCTTGTAAAAATCGGATATAAAAAAAC
+AGCCCTCATTGCCATGGCAGTAGGTTTCATCGGTTTGTTTATCCAATATATTTCCAGTTT
+GTTCGGTGCAGATATAGACGTATTCAATTTAGGAGAATATGCCATTAAAATGAATTTTAT
+CATCTACCTGCTTGGTGCTTTCGTCTGTGGTTTTTGTGTATGTATGCTGAACACAGTAGT
+TAACCCGATGCTAAATCTTTTAGGTGGTGGTGGTAACAAAGGTAACCAATTAATCCAAGC
+CGGTGGTGCTCTAAACTCATTGTCAGGTACTTTGACTCCGCTTTTCGTAGGTGCCTTGAT
+TGGTTCTGTTACCCCTCAAACAGCTATGTCAGATGTAGCTCCTCTGCTTTTCATCGCAAT
+GGGTGTATTCGTATCAGCGTTTATCGCTCTTTCATTCATCGCCATTCCAGAGCCTCATCT
+AAGAAAAGCAGGTCATGAAAAAGAGAAATTCTCTCATAGTCCTTGGAATTTCCGCCATAC
+TGTATTAGGTGTAATCGGTATCTTTGTGTATGTAGGTATTGAAATCGGTATTCCAGGCAC
+ATTAAATTTCTATCTTGCCGACCCAACGGAAAAAGGTGCGGGTCTGCTTGCCAACGGTGC
+CGCTATCGGTGGTGCTATTGCTGCCATCTATTGGTTGCTCATGTTAGTGGGACGTTCTGC
+AAGTAGTGTCATCAGCGGTAAAGTAGCTACACGCACACAATTGATTGTTGTTTCCGCAAC
+AGCTATCTGTTTTATATTAATCGCAATCTTCACTCCAAAAGAAATCACTGTCTCTATGCC
+GGGATATAGTGTAGAAAATGGATTCGAAATGGCCTCTGTACCTGTCAGTGCCCTATTTTT
+GGTACTTTGTGGTTTATGTACGTCCATTATGTGGGGAGGTATCTTCAACCTCGCTGTAGA
+AGGTTTAGGCAAATATACCGCACAAGCTTCAGGTATTTTTATGATGATGGTTGTCGGTGG
+CGGTATTTTCCCATTATTGCAGCAATTCATTTCTGACGCTGTGGGATATATGGCCAGCTA
+TTGGTTAATTATCGCTTTGCTTGCTTATCTGTTGTTCTATGGTTTGGTAGGATGCAAGAA
+CGTAAACAAAGACATTCCTGTAGAATAATTATAAAAACATATAGTATTAACTTTAAACTA
+TTAATATCATGGATATAGAATACGTAAGAAGTCGCTTCATCAAACATTTTGATGGCACAA
+CAGGTTCAGTATATGCATCACCCGGACGTATTAACCTTATTGGAGAACATACCGACTATA
+ACGGTGGTTTTGTCTTTCCCGGAGCAGTAGATAAAGGTATGATTGCTGAAATCAAACCTA
+ATGGTACTGATAAGGTACGTGCTTATTCTATTGATCTAAAAGACTATGTAGAATTCGGCT
+TGAACGAAGAAGATGCCCCTAAAGCCAGTTGGGCAAGATATATTTTCGGCGTTTGCCGTG
+AAATGATCAAACGTGGTGTAGATGTGAAAGGTTTTGACACTGCTTTTGCGGGTGACGTAC
+CTTTGGGTGCAGGTATGTCTTCATCTGCTGCATTGGAAAGTACGTATGCTTTCGCTATCA
+ACGAACTTTTCGGTGACAACAAAATAGATAAATTTGAATTAGCCAAGGTAGGTCAGGCAA
+CAGAACATAATTATTGTGGTGTAAATTGCGGTATTATGGATCAATTTGCATCTGTATTCG
+GAAAAGAAGGTAGTTTGATCCGTTTGGACTGTCGTTCATTGGAATATCAATACTTCCCGT
+TCAAACCGGAAGGTTACCGATTGGTATTGGTTGACTCGGTAGTCAAACACGAATTGGCTT
+CTTCTGCTTATAATAAACGTCGCCAAAGCTGCGAAGCTGCTGTAGCCGCCATCCAGAAAA
+AACATCCTCATGTAGAATTTTTACGTGATTGTACAATGGAAATGTTGCAGGAAGCAAAAG
+CCGAGATCAGTGAAGAAGACTATATGCGTGCAGAATACGTCATTGAAGAAATCCAACGTG
+TACTTGATGTTTGCGATGCTTTGGAAAGAGGTGATTACGAAACCGTAGGACAGAAGATGT
+ATGAAACCCACTATGGCATGAGTAAATTGTATGAAGTAAGCTGTGAAGAACTTGACTTCT
+TGAATGATGTTGCTTTCGACTGCGGTGTCACCGGTTCACGTGTCATGGGTGGAGGTTTCG
+GTGGATGTACAATCAACCTAGTTAAAAATGAACTATACGAAACATTCATCACCACTGCCA
+AAGAAAGATTCAAAGAGAAGTTCGGAAGAAGTCCCAAAGTTTACGATGTAGTCATCAGTG
+ACGGTTCTCGCAAGCTGGTATAAAAAAGATCTCAAATTCGCTAACATATGAAAAAACCGC
+TTTGGATTCAAAGCGGTTTTTTCTTCTTTATGCTATAAAAGTGTAGGAAATACACTTTTA
+TGTTGCACAACATACTCTTTTCATATCCAATGTATTAGTAATAGTGTTACTTTTACACCC
+AAAATCATATACTCTATTACTAATTAGTACTTTTATATCATGAAAAGCATGAAAAAAACC
+TTTCTGGGAACCGGTATCGCACTGACCTTGTTAAGTGCTTGCGCTCCCAAACAATCTCAA
+GAAACACTTACAAAGTCCGGATTAAACCCCACTAATTATGAAACAATAGTGGATGGCGTA
+AAACCTGTTAAACTGTATACGCTAAAGAATGCAGCCGGAATGGAAGTATGCGTAACTAAT
+TTTGGCGGACGTATTGTATCTATCATGGTCCCCGACAAAAATGGAAATCTAAAAGATGTA
+GTGCTGGGTTTTGACAGCATTGCTGACTACCAAAATATACCAAGCGACTTCGGTGCTTCT
+ATCGGACGCTATGCCAACCGCATTAATAAAGGAGTCATCGTAATGGATGGAGAAACCATT
+CAATTACCCCAAAATAATTTTGGTCACTGCCTGCATGGAGGTCCTAAAGGATGGCAATAC
+CAAGTTTATGAAGCAAACCAATTAAACGACAGTACTATGACACTGACTATGAAGTCACCG
+GATGGAGATGCCAATTTTCCGGGAAATGTAACCGCTACTGTTACTTATGCACTGACAAGA
+GACAATGCCATCGACATAAATTACGAAGCGACAACTGACAAAAAGACTGTTATCAATATG
+ACCAACCACTCTTATTTCAACTTGAGTGGAAACCCTGCCAATCCGGCCACCGACCATATT
+CTTTATGTAAATGCAGACAGCATCACTCCCGTTGACAGCACATTCATGACCACTGGAGAA
+ATGATGGCAGTAACAGAAACTCCATTTGATTTCAATACTCCTAAAACCATTGCCCCCGAT
+GTGACTAACTTTGAAAACGAACAAATAAAATTCGGTAACGGATTCGACCATAATTGGGTA
+CTTAACACGAAAGGCGATATCAACCAGCTGGCTGCCAAACTGACCAGCCCTACTAGTGGT
+ATCACTTTGGAAGTATATACTAATGAACCGGGAATACAAGTTTATACAGGCAACTTTTTG
+GATGGAACCGTAAAAGGGAAAAAGGGAATTACTTATCCGCAACGCGCGTCTGTTTGTCTG
+GAAACACAGCACTATCCCGACAGCCCCAACAAATCACAATGGCCTTCTGTAATTCTGGAA
+CCGGGACAGACCTATCACAGCCAATGTATCTTTAAATTCGGTGTTGAAAAATAATTGTTA
+AACTTTAAATATTTAATATCATGAATTGGAATTCACATGAATTCATCTGGCTGGACTGGA
+CAATACTGGCAGTCGGCATTGTAGCTGTGATATGGGCGGTATGGCGCTCTGTACAAAAAG
+ACAAACGCTCGCAACAAGGAGCAAGCAGTGAAGATTATCTATTTGGCAAAGGTGAGCCAT
+GGTACATCATTGGTGCTGCTATCTTTGCAGCCAATATCGGTTCGGAACATCTGGTAGGTT
+TGGCAGGAACCGGTGCCAAATCCGGAGTAGGTATGGCACACTGGGAAATGCAAGGTTGGA
+TGATTCTTCTTCTAGGATGGCTTTTTGTTCCATTCTACCAACTATTAAACAATAAAATGG
+GCAAAATCATTACCATGCCCGATTTCCTTAAATACCGTTATACCCCGCGTACCGGTTCAT
+GGCTTTCTATCATCACACTGATAGCCTACATTCTTACTAAAGTGAGTGTAACCGCCTATA
+CCGGAGGTATCTTTTTGGAGTTCTTACTTGGACTTCCTTTTTGGTATGGGGCAATCGGAC
+TTATTGTCCTGACCGGCATCTTCACCGTACTGAGTGGAATGAAAGGAGTAATGACCCTCT
+CAGCTATTCAAACCCCTATTTTAATCATCGGTTCTTTCTTGGTTCTTTTCCTGGGACTGT
+CAGCCTTGGGAGACGGTAATATTGCTACAGGATGGACAGAAATGATGGATCATGCGCGTA
+GCGCCATGAATGTAGGAGCAGACGGACACGCTTATGGTGCCAACCATATGTTTCACTGGA
+CCGAAGCAGACCCGATGTATCAAGATTATCCTGGATTCTGGGTATTTATCGGAGCTTCCA
+TCATCGGTTTCTGGTATTGGTGTACCGACCAGCATATCGTACAGCGTGTACTTGGACAGC
+GTAAAGGCGAAGATAATGATGTGGTAATGAAGCGTGCCCGCAGAGGTACTATTGCAGCCG
+GTTATTTTAAAATCCTGCCTGTCTTCATGTTTCTTATTCCGGGGATGGTAGCTGCCGCCT
+TGGCTGCAAAAGGTGAATTTGATATGTCAAATACAGATGCGGCTTTTGCTGTAATGGTAA
+AGGATGTTCTGCCTGCCGGTGTAAAAGGTATTGTAACTATCGGATTCATCTGCGCATTGG
+TTGCTTCACTGGCTGCTTTCTTTAATTCATGCGCCACACTTTTTACAGAAGACTTTTACA
+AGCCCATGTTTAAAAACAAAAGTGAAGCTACTTATGTTATGGTAGGACGTATCGCCACCG
+TAGTTGTAGTTATCCTCGGCATGGCATGGATTCCTGTAATGATGAGCCTCGGCAGCCTTT
+ACGACTACCTGCAAGGCATACAGTCCCTCCTTGCACCTGCAATGGTAGCCGTATTTGCAC
+TTGGTATATTCTCCAAGAAAATCACTCCGAAAGCCGGTGAAACAGCCATGATTGTAGGTT
+TCCTAATTGGTATGCTCCGTTTGCTGACTAATATCCTCACCAATACCGGAAAAGATGTGA
+TGACCGGCTGGTTTTGGGAAAATACAACTTGGTTTTGGCAGACAAACTGGCTTATTTTTG
+AAATATGGCTACTTGTATTCCTCTTGTTGTTAATGGTTGTTGTATCATGCTTCACTCCGG
+CTCCAACCGCCAAACAAGTGGAAGCCATCACCTTTACCGGCAGTTACAAGGAACTTATCA
+GAAAGAGTTGGAACAAATGGGATGTTATTACCTCTTTAGGTGTAGTTCTGCTTTGTGCAC
+TATTCTATGCTTATTTCTGGTAAACCATAAATTAAAGGCTGTATGCTTTGAATTATCTTG
+AAGAATACAGCCTGTTAATTTTAAACCGACGCTAAACCATGACCACCTATTATAACATAA
+ACCCTAAATTCTATGTATCTGTAGACTGTATCATTTTCGGTTTTGACGAAGGAGAATTAA
+AACTGCTTCTACTAAAACGAAATTTTGAACCGGCTATGGGAAAATGGTCTTTGATGGGAG
+GATTCGTACAAGAAGACGAAAGTGTAGACGCTGCCGCCAAACGGGTATTGGCAGAACTGA
+CCGGATTGGAAAATGTATATATGGAACAAGTAGGCACATTTGGCGACTTAGAGCGCGATC
+CGGGAGAACGAGTCATATCAGTAGCCTATTATGCTTTAGTCAATGTAAATGAATATGACA
+GGGAACTAGTGCAGCAGCACAATGCCCATTGGACAAAAATAGACGAACTGCCACAGCTCA
+TTTTCGACCATCCGATCATGATTTCCAAAGCACGTGAACTGATGAAGCACAAAGCATCAT
+ACAATCCAATTGGTTTTAACCTGCTGCCCGAACTGTTTACCCTGACACAGTTGCAAAATC
+TATATGAGGCAATCTATGGCGAACCGATGGACAAGCGGAATTTCCGCAAGCGGGTAGCCG
+AAATGGATTTCATTGAAAAAACAGATTTGATAGACAAATCAGGTTCCCGACGAGGTGCTT
+ATCTTTATAAATTTAATGATAAGGCCTACAGAAAAGATCCGAAATTTAAACTTTAAAATA
+ATGTGCCGATGCAATAATTTGCCAATTGACAAATTAGCAGATTGCCACATTACCCAATTA
+TTCATTATGTTAGAAAAATTAAAAGAAAAAGTATTCCGTGCCAATCTGGATTTGGTGAAA
+CACGGACTAGTTATTTTTACATGGGGAAATGTTTCTGCCATCGATCGTGAAACAGGTCTG
+GTAGTAATCAAACCCAGTGGCGTATCATACGATGATATGAAAGCTGAAGACATGGTTGTA
+GTAGATCTGGACGGCAACGTGGTAGAAGGTTCTCTTCGTCCGTCTTCAGATACTCCCACC
+CATGTAGTTCTATATAAAGCATTCCCCGAAATAGGTGGAGTGGTACATACCCACTCCACC
+TATGCTACCGCCTGGGCACAAGCCGGAATGGATATCCCCAATATCGGAACGACTCATGCC
+GATTATTTCCATGACGCCATTCCTTGTACCGCAGATATGACTGAAGAGGAAGTAAAAGGT
+GCCTACGAACAGGAAACAGGCAATGTGATTGTGAAACGTTTCAAGAACCTGAACCCTGTA
+CATACTCCGGGAGTACTAGTAAAAAATCATGGTCCTTTTGCATGGGGAAAAGATGCCAAT
+GATGCTGTACATAATGCAGTAGTCATGGAACAGGTAGCCAAAATGGCAAGTATCGCTTTT
+GCCGCCAACCCTCATTTAACGATGAATTCTTTATTAATAGAAAAGCATTTCAGCCGCAAA
+CACGGCCCCAATGCCTATTATGGACAGAAATAAGAAACAAAGAAATTAATAACCCTTTTA
+AAATATAACATTATGGAAAAAGCATTTGATCAGTATGAAGTATGGTTTGTAACAGGAGCA
+CAGCTTCTGTACGGAGGTGACGCAGTTATAGCAGTAGACGCTCACTCCAATGAAATGGTA
+AACGGACTGAACGAATCAGGGAAACTTCCTGTAAAAGTAGTATATAAAGGAACAGCCAAC
+TCTTCTAAAGAAGTGGAAGCAGTGTTCAAAGCAGCCAACAACGATGAAAAATGTATCGGT
+GTCATCACTTGGATGCACACTTTCTCCCCAGCTAAAATGTGGATTCACGGTCTGCAACAG
+TTAAAGAAACCACTGTTACATCTACACACTCAATTCAATAAGGAAATTCCTTGGGATACC
+ATGGATATGGACTTCATGAATCTGAATCAATCCGCCCATGGTGACCGCGAATTCGGACAT
+ATCTGTACCCGTATGCGCATCCGCCGCAAAGTAGTGGTAGGTTACTGGAAAGACGAAGAC
+ACCCAGCACAAGATTGCCGTTTGGATGCGTGTTTGTGCAGGTTGGGCAGACTCTCAGGAT
+ATGCTGATCATCCGTTTCGGCGATCAGATGAATAATGTAGCTGTAACTGACGGTGATAAA
+GTGGAAGCAGAACAACGTATGGGGTATCACGTAGATTACTGTCCGGCAAGCGAACTGATG
+GAATACCATAAAAACATCAAGGATACAGATGTAGAGGCACTTGTAGCAACTTACTTCAAC
+GAATACGACCACGATGCTTCATTAGAAGATAAATCAACCGAAGCTTATCAGAAAGTATGG
+AACGCTGCAAAAGCCGAATTAGCTCTTCGTGCCATCCTTAAAGCCAAAGGCGCCAAAGGA
+TTCACTACTAATTTTGATGATTTGGGCCAAACAGACGGCAGCTACTTCGATCAGATTCCG
+GGACTGGCTTCCCAGCGTCTGATGGCTGAAGGCTACGGATTCGGTGCGGAAGGTGACTGG
+AAATCAGCAGCTCTCTACCGTACCGTATGGGTGATGAACCAAGGACTTTCCAAAGGTTGT
+TCTTTCCTGGAAGATTACACATTGAACTTCGATGGTGCAAACAGTGCTATCCTGCAATCA
+CATATGCTGGAAGTTTGCCCTCTTATCGCCGCTTCCAAACCACGTCTGGAAGTACACTTC
+CTAGGCATAGGTATTCGCAAGAGCCAGACAGCCCGTCTTGTATTCACTTCAAAAGTAGGC
+TCAGGTTGTACCGCCACTGTAGTAGACTTGGGTAACCGTTTCCGTCTGATCGTGAACGAC
+GTAGAATGCATCGAGCCGAAACCGTTGCCCAAATTACCGGTTGCTTCCGCCCTGTGGATT
+CCGATGCCTAATTTCGAAGTAGGTGCAGGCGCATGGATCCTGGCAGGTGGAACACATCAT
+TCTTGCTTCTCTTATGATCTGACAGCAGAATATTGGGAAGACTATGCTGAGATTGCAGGT
+ATCGAAATGATCCGTATCGACAAAGATACTACCATCAGCAACTTCAAGAAAGAGCTTCGC
+ATGAACGAAGTCTACTATATGCTGAACAAAGCACTTTGCTAATTCATCCATGAAGAGGGG
+ATGTGTCAAGGCTAATAAGATTCTTGGCACATCCCACCTTATTTTATCATCATTATTGTT
+GTACCTTAAATTATAGGTTTTAATATGAAATCAGATGCAAAATCAACCATCCAAGCAGGA
+AAAGCTATTCTAGGCATAGAATTCGGATCAACACGAATCAAAGCTGTTTTGATTGACCAG
+GAAAACAAGCCCATTGCCCAGGGAAGCCACAGCTGGGAAAACCAACTGGTAGACGGACTG
+TGGACTTACAGTGTGGAAGCTATCTGGCATGGCCTGCAAGACTGCTATGCAGATCTCCGT
+TCCAACGTAAAAAAGCTATATGACACAGAAATAGAAACCTTGGCGGCAATCGGTGTCAGT
+GCCATGATGCATGGTTATATGGCATTCAATAAAGAAGAAGAAATCCTTGTACCTTTCCGT
+ACATGGAGAAATACCAATACCGGTCCGGCAGCCGCCGCTTTATCTGAATTATTCGTATAT
+AACATTCCTCTGAGATGGAGCATTTCTCATTTATACCAAGCTATTTTAGACAATGAAGAA
+CACGTAAGTAACATTGACTATCTGACCACCCTTGCAGGTTTCATTCATTGGCAAATTACA
+GGTCAGAAAGTTCTGGGCATAGGTGATGCATCAGGAATGCTTCCCATAGACCCGGCTACC
+AAGAATTATTCTGCCGAAATGATAGCCAAGTTCGACAAGTTGGTAGCTCCTAAAGGATAC
+CCTTGGAAACTGACAGATATCCTGCCCAAAGTCTTACCCGCCGGCGAGAATGCAGGGTTC
+CTTACCCCGGAAGGTGCCAAGAGGCTGGACGTGTCGGGCCACTTGAAAGCAGGTGTACCT
+GTCTGCCCTCCGGAAGGAGATGCCGGAACCGGCATGGTAGCAACCAACGCTGTCAAGCAA
+CGCACCGGGAATGTATCAGCAGGCACTTCCTCATTTTCCATGATTGTATTGGAAAAAGAG
+TTGTCCAAGCCATACGAAATGATTGACATGGTTACCACTCCCGACGGAAGCCTTGTAGCT
+ATGGTACATTGCAACAACTGCACCTCCGACCTCAATGCCTGGATCAATCTGTTCAAAGAA
+TACCAAGAACTGCTGGGTATACCCGTAGATATGAATGAATTATATGGAAAACTTTACAAT
+CATGCGCTCGCAGGCGATGCAGATTGCGGTGGTCTTATTTCGTATAATTATATTTCAGGT
+GAACCCGTGACAGGACTTGCCGACGGAAGGCCATTGTTTGTACGTTCTGCAAATGACAAA
+TTCAACCTCGCCAACTTTATGCGTACCCATTTATACGCTTCAGTCGGAGTTCTTAAGATA
+GGTAATGACATTCTTTTCAATGAAGAGAAAATCAAAGTAGACAGAATCACAGGACACGGC
+GGATTATTCAAAACGAAAGGTGTAGGCCAGAGAATACTTGCAGCAGCTATAAACTCCCCT
+ATTTCCGTAATGGAAACTGCCGGTGAAGGTGGCGCATGGGGAATCGCCCTGCTAGGTTCT
+TACCTTGTCAACAATGAAAAGAACCAATCCCTGGCAGATTTTCTGGAAGACAAAGTATTC
+GCCGGTGATGCCGGTATTGAAATATCGCCAACAGCCGAAGATGTAGCCGGATTCAACACA
+TATATCGAAAACTATAAGGCAGGACTGCCTGTTGAAGAAGCAGCGACCCGATTTAAGAAG
+TGAGTCAAACGGGCTTAAAAAAGAGCCTCTTTACATGTTGCGGTTTACACATAAAGAGTT
+ATCTTTGCAGATATTAAATAAAATAGCAAAGATAAACCGACTCACTAATAGCATTCAAAT
+TATAATATTATTTTAATATGAACGAAAAGAAACTTATGAACCGTGCAGCGGACAACATCC
+GTATTCTGGCTGCTTCGATGGTAGAGAAAGCTAATTCAGGACACCCGGGTGGAGCTATGG
+GTGGCGCTGATTTTGTAAACGTGCTTTTCTCTGAGTTTTTAGTTTACGATCCTGAAAATC
+CGCGTTGGGAAGGGCGTGACCGTTTCTTCCTTGATCCAGGCCACATGTCACCGATGCTGT
+ATTCCACTTTGGCACTGACCGGCAAGTTCACCATGGAAGAACTGGCACAGTTCCGCCAAT
+GGGGCAGTCCGACTCCGGGACACCCTGAAGTGGACATCATGCGCGGTATTGAAAATACTT
+CCGGCCCGTTAGGACAAGGACACACTTTTGCAGTAGGTGCTGCTATCGCTGCCAAATTTC
+TGAAAGCCCGTCTGGGTCATGTCATGGACCAGACCATCTATGCCTATATATCCGATGGGG
+GTATTCAAGAAGAGATTTCTCAGGGTGCAGGCCGTCTGGCAGGTCATTTGGGGCTGGACA
+ACTTGATCATGTTTTATGATTCAAACGACATCCAGCTGTCTACCGCTACCGATGCTGTTA
+CCAGCGAAGATGTTGCCAAGAAATACGAAGCATGGCACTGGAAAGTAATTACCATCGACG
+GTAATGATCCCGATGCAATCCGCACGGCTCTGACAGAAGCGAAAGCCGTAACCGGCCAGC
+CCACATTAATTATCGGTAAGACCATTATGGGTAAAGGCGCACGCAAAGCGGATGATTCCA
+GTTATGAACGTAACTGTGCCACCCACGGTGCTCCTTTGGGAGGTGATGCTTACATCAATA
+CAATCAAGAACTTAGGCGGCGATCCAACCAATCCTTTCCAAATCTTCCCTGAAGTAAAAG
+AGTTGTATGCCAAACGTGCAGAGGAACTGAAAAAAATTGTTGCAGAAAAATATGCGGCTA
+AAGCTGAATGGACTAAAGCTAACCCCGAACTGGCTGCTAAATTGGAACTATGGTTCTCTG
+GCAAAGCTCCGAAAGTAAATTGGAATGTTATCGAACAAAAAGCCGGAGATGCTACACGCA
+GCGCTTCTGCCAAAGTTCTCGGTGTACTGGCTACAGAAGTAGAAAACATGATCGTTTCTT
+CTGCCGACCTGTCAAATTCAGACAAGACCGACGGTTTCTTGAAGAAAACACATGCATTCA
+CAAAAGACGACTTCACCGGTGCATTTCTGCAGGCAGGTGTTTCCGAATTAACCATGGCTT
+GCTGCTGCCTGGGTATGGCACTTCACGGAGGTGTGATTGCTGCATGCGCTACCTTCTTCG
+TATTCTCAGACTACATGAAACCCGCCATACGTATGGCTGCCTTGATGGAACTTCCCGTCA
+AATTCATCTGGACACACGACGCATTCCGTGTAGGTGAAGACGGTCCTACTCACGAACCGG
+TAGAACAAGAAGCACAAATCCGCCTGATGGAAAAACTGAAAAACCACAAAGGACACAATT
+CTATGTTGGTACTCCGTCCGGCAGATGCGGAAGAAACCACTGTGGCATGGAAATTGGCCA
+TGGAAAATACCAGCACCCCCACCGCACTGATCTTCTCCCGCCAGAATATCGCGAATCTGC
+CTGCAGGAAACGACTATTCACAGGCTGCCAAAGGCGCTTATATTGTTGCAGGCTCCGATG
+AAAATCCGGATGTAATCCTAGTCGCTTCAGGTTCCGAAGTTTCCACTTTGGAGGCAGGTG
+CAGAACTTCTCCGCAAGGATGGCATAAAAATACGTATCGTATCCGCTCCTTCTGAGGGAT
+TGTTCCGCAGCCAAAGCAAGGAATACCAAAACAGTATCATTCCCACAGGGGCTAAAGTAT
+TCGGTCTGACTGCCGGTCTTCCTGTAAACCTTGAAGGTTTGGTAGGTGCCAACGGTAAGG
+TATTCGGTCTGGAATCATTCGGATTCTCCGCTCCTTACAAAGTATTGGATGAAAAGCTGG
+GCTTTACCGCACAGAACGTGTATAACCAAGTAAAAGAAATGCTGGCATGAAAAAAGTAGG
+ACTGGCATCCGATCATGCAGGATTTGAACTGAAAGAGTTTGTAAAGACATGGTTAACTGA
+AAAAGGCTATCCATGCAAAGATTTCGGTACATACAGTACAGAAAGCTGTGACTATGCAGA
+TTATGCCCATCCGCTTGCACTGGCTATAGAAGCCGGAGAATGCGGACCCGGAGTGGCAAT
+TTGCGGAAGCGGTGAAGGCATCAGCATGACATTGAACAAACATCAGGGTATCCGTGCGGC
+ACTATGCTGGATGCCCGAGATAGCCCATCTGTCACGTCAGCACAATGACGCCAATGTTCT
+GGTAATGCCGGGACGATTCATTGACCATGAAATGGCCGAAAAAATATTGGATGAATTCTT
+TAACAGCGGCTTCGAAGGCGGACGTCACCAAAAGCGCATTGAAAAGATACCTGTAAAGTA
+AAATTCACGCAATAATAATAAAAGTAAAAAAAGAGAGGCATTATAGCTTCTCTTTTTTTT
+TATTCCTATCTTTGCTTAGATTAAAATATAAAATAAAAAATATTACTATGAAGAAGATTC
+TTTTTTTAATGCTCCTATGTCTGCCATTCATCGCTATGGCACAGACAGATCCCAAATATC
+TGGCGGGAGCGATAACTATGGATGACGGTAAAGTTTCTTTCAAAACAGAGATACAGGCAC
+CGTCTTTAACGAAAGACCAGCTATATGGCACCATGCTGAAATGGGCCACAGAACGTTTCA
+AGCCCGAAGGCAAGTTCAATGCACGTGTTCTTTACACCAATGAAGATGAAGGAACCATTG
+CAGCAGGTGGCGAAGAATATCTGGTATTCTCCTCCTCTGCATTGTCATTGGACAGAACCA
+GAATTTATTATCAGTTGTTTATCACCTGCGAAAACGGAAAATGTGATATCGAAATGACCC
+GTATCCGTTATTGGTATGATGAAGCTCGTGACGGAGGAGAAAAATACAGTGCAGAGGAAT
+GGATTGTAGACGATATGGCTTTAAACAAATCGAAGACCAAGCTGGCTCCCATCTGCGGCA
+AATTCAGAAGAGAGACTATTGACTTGAAAGACACACTGTTCAAATCCATCCAAGATACAT
+TGGGCAACAAGGTCTTGAACAACTCACAAATTGCAGTTGCTCCTGCTCCGGGCGTGACAG
+CTACTCCGATATCAAATGCAACAACAATCGTTACCGCCACTCCGGTAACTCCCCCTGCCC
+AACCGGCTGTCATCGGTGGTTCTGAGGGTAATACCGAAATAAAAGCAGCCAATAATGCAA
+CTCCCAGCAAAGAACAAAGCATAGATGACCAAATCAAGGCATCCTCACGTATGACAATTA
+CTGCCGGAAACGATGAACAATTCGAAATCGGTAAAGAATGCTGGGGAGGTTTCGGCCAGT
+TATTCGGCAAAGAAGTAGCATTCTGCGTAATCGACCAAGCCAAATCAATGGGCAATATGC
+TGATGGATCAGAGCGATAATTATAAAATTTCGTTCTACAAGCAAGGTAATAGCGAGCCGT
+GGTTGATAGTAAACTGCAAGAAACTGATGAAACAGACCGTTACCGGTGAGGAAGCAAAAA
+AGATGAACCCCAGTAATGACGGTCAGAAGGCATATAATATGTATGTAGGTGAAGTAATAA
+AATAGTCTTTTCTCCCATATATTTATACCGTGACAGTTTATTCTGATAATACATAAAACT
+TTTTTTAGGGGGAGATAACCTGACAACTCCCCCTAAAAAACATACAAACGATCTACCATA
+TACTTCCCCAAAAGCACCATGACAAATACCATTCAAACATGTCTCCCCTTTAAGAATAAA
+TAACACCGTTCCTCTATCAACCGTTTCACTTGAAACCATTTCTATAATAATCAAACCATT
+AGAAGAAATCATTCTTCCATTTTTTCCCTATCTTTCTCTCCTTTTTTTAAATGTTTTTAG
+CAAGAAAGCCGTTTTTTCTGCTCCAATCTTCCCTTTCATAACAAATAAAGAGTATCTTTG
+TAAACAACAATGAGACAATCATGCCTTATGACGGAACAATTACAGGACATAAAGACACTT
+ATCGAACAGGGTGATACGGAAAGAGCCATTCATGCGCTAACTAATTTCATCCGAAACGAT
+GCGCACGTCAACGATGAACCCTATTACTTACTGGGTAACGCCTACCGCAAAATGGGAGAC
+TGGCAACAAGCTTTGAACAATTATCTGGAAGCCATCGAGCGTAATCCGGAAAGTCCGGCC
+GTTTCCGCCCGTGACATGATTATGAATATTCTGAATTTCTATAACAAAGACATGTATAAT
+CAATAATAACTAACCCATGGCAAAGATTAAAGGTGCTATTGTAGTAGACACAGAGCGTTG
+CAAAGGTTGCAATCTATGTGTAGTGGCATGTCCGCTGCATGTAATCGCGCTCAATGCCAA
+ACAAGTGAATAAAAAAGGATACACATTCGCCCACCAGGTATTAGAAGATACCTGCAATGG
+TTGCGCATCATGTGCCACAGTCTGTCCGGACGGATGCATCACTGTGTATAAAGTAAAACA
+ACAATAAATGTAACAAATATGGCAGAAGAAGTCGTTTTAATGAAGGGAAATGAAGCCATA
+GCCCACGCCGCTATCCGTATCGGAGTAGACGGTTACTTTGGCTATCCCATCACTCCCCAA
+TCGGAAATATTGGAAACGCTGGCCGAAGAGAAACCTTGGGAAACTACCGGTATGGTGGTG
+TTGCAGGCAGAAAGTGAAGTCGCAGCAATCAACATGGTATATGGCGGTGCAGCGAGCGGT
+AAAATGGTAATGACCTCATCCTCCAGTCCCGGCGTCAGTTTAAAGCAGGAAGGCATCTCG
+TACATTGCCGGTGCCGAACTCCCCTGCCTGATTGTCAATGTCATGCGCGGAGGTCCCGGA
+TTAGGAACCATCCAACCTAGTCAGGCCGACTATTTCCAAACAGTGAAAGGCGGCGGTCAC
+GGAGACTATCGCCTCATAGCCCTGGCTCCTGCATCAGTACAGGAAATGGCAGATTTCGTA
+GGTATAGCTTTTGATCTGGCTTTCAAATACCGCAATCCCGCCATTATTCTGGCAGACGGC
+GTTATCGGACAGATGATGGAAAAAGTAGTATTGCCCGAACAGCGCACACGCCTGACAGAT
+GAAGAAGTCATAGCCCGTTGTCCGTGGGCCACTACCGGCAGAACCCACCACCGTACTCCC
+AACATCATCACCTCATTGGAACTCGATCCTGCCGAGATGGAAAAACGTAATATCCATCTT
+CAGAAAAAATATGCAGAAATAGAAGAAAACGAAGTACGTTTCGAAGAACTTCACTGCGAA
+GATGCCGAATATTTGATCGTAGCTTTCGGTTCTTGTGCCCGCATTGCCCAAAAAGCAATG
+GAAATGGCTCGGGAAGAAGGCATCAAAGTTGGTTTGCTCCGTCCTATTACCCTATGGCCG
+TTCCCGTCGAAAGCTATTGCAGCACGCGCCGCACAGGTAAAAGGTATCCTCACTGTAGAA
+TTGAACGCCGGACAAATGGTAGAAGATGTCCGTCTGGCCGTAGAATGCAAAGTGCCTGTA
+GAACACTTCGGACGTCTGGGTGGTATTGTTCCCGATCCGGATGAAGTAATCACTGCACTG
+AAAGAGAAACTAATAAAATAAGACCGTATGAATATCGATCTGATCAGAAACATATTGAAC
+ATACTTTTCATGGCACTGGCACTAGCGGCTGTCATCACTTACTTCATGGCAAGTGACTTC
+AAAGTATTCATCTATGTCTGTGCAGCAGCTATTTTTCTCAAGCTGATGGAATTCTTTATG
+CGGTTCATGTTATAAGCAATAGGAGGAGAAACTATGACAAAAGAAGAAATCATAAAACCC
+GAAAACCTGGTTTATAAGAAACCGACACTGATGAATGACAATCCGATGCATTACTGCCCC
+GGATGCAGCCACGGTGTGGTTCACAAGTTAATAGCCGAAGTTATTGAAGAAATGGGCATG
+GAAGATAAGGCAATCGGTGTGTCACCGGTAGGATGTGCCGTTTTTGCATACAACTATCTA
+GACATCGATTGGCAAGAAGCCGCCCACGGACGCGCACCAGCCGTAGCTACCGCCATCAAG
+CGTTTATGGCCCGGACGTCTGGTATTTACCTACCAGGGAGATGGTGACCTGGCATGTATC
+GGCACTGCCGAAACCATCCATGCTTTAAATCGTGGCGAAAACATTACTATCATCTTTATC
+AACAACGCCATTTATGGAATGACCGGTGGGCAAATGGCTCCTACCACGCTGGTTGGCATG
+AAGACAGCCACCTGCCCCTATGGTCGTGATGTAGCCATTCATGGCTATCCGCTGAAAATG
+ACAGAAATTGCCGCCACTTTGGAAGGCACCGCCTACGTTACCCGCCAGGCCGTACATACG
+GTTCCTGCCATCCGCAAAGCAAAAAAGGCTATCCGCAAGGCATTCGAAAACTCAATGAAT
+GGCAAAGGATCCAATTTGGTGGAAATTGTATCGAC
+>NODE_5_length_39999_cov_63.277_ID_9
+CGATCAATTGGTAACAGATATTCGTGAAATGAACCAGAAACCAGTTAAAAAGCAATTGCG
+TTTAGGCTTAACTACTTTATTTGCTGTACAATTTATGAAAGAAATTTCACGATTTTTAAC
+AACCCATCCACATGTGAATTTAATATTACAGCAAGATGGCTCGCCAAAATTACAAACGAT
+GTTAGCAAATAAAGAAATTGATATGGGACTAATTTCTTTCCCAAATACCTTACCTGAAAT
+TATTCATATTGAACCTTTAGAAACGACTACCAAAGGCTACCATGTTTATGTCGTAGTACC
+AGAATCAAATCCTCTCTCCCAATATGAAAAATTAACTTTTAAAGATTTGAAAGATCAACG
+ATTTTCATCGTTAAGTGATAATTTTATGATTGGTCGCCTACTACTAGATCGGACTCGGAG
+CTTCGGTTATGAGCCGAATATCATTTTGCATAACGATGATTTACAAGTACTTCTTTATAG
+TTTACAAAAAAATAATTCGATTTGTTTGCTGCCGATTGAATATTATGAAGTGGGAAAAAG
+TCAGGGACTGAAATGGATTCCTTTAAAAGATAAGTTTGACTATTTCCCCATCGGCATTGC
+TTTGCGCCGCGATTTTAGTATGACAGAAGATGTTAGAGATTTTATCCAAATCATTAAAGA
+AAATTAATGGATAATCTAGCCTTGATAAGCAAAGACGACTTTACTATCATAAAGTTTCAA
+CACTTTTTCAAATAAGAATTTTGAGAATAAACCCGCGACAATTGGAACAACAAACCAAGA
+AAAGAATAAGGGTAAGATCCCTAAGCCCGCATCCAATGAAGCAAGTGGTCCCACGAGTCC
+AACCAAGCCAAATCCAGCCGATTGTGGGGTTCCTGAAATGTTGAATAGAACCACAGGAAT
+TGCTGAAATAGTCGCTGTAAATAAACAAGGAATTAAAATAATTGGGTATTTAAATAAATT
+AGGCATCATCATTTTCATGCCGCCCAAAGAGACAGCCAACGTCACTCCCGATTGGTTGAC
+ATTCCAAGAATTAATCACAAGAACAACAGTTGTGGCTGCAATTCCCATTGCAGCAGCACC
+TGCAGACAAGCCATTCAACTGAATCGCCAAACCGATTGCCACAGTAGTGATTGGTGAAAT
+AATCAGTGCAGCAAATGAACAAGCAATTAAAATACTCATGATAATTGGCTGGAAATCAGT
+AAAATTGTTAATCACTTTCCCAATGGCGACCGTAATTTGTGTCACATATGGATAAATCAA
+CATGCCAAACAAACCTGCACCTACTCCAACAACGATCGGTAAAGCAATGATTTCCACTGA
+ACCGAATTTTTTATCGATGACTAATAAAAGTAAGACTGCAACAGAAGCGGTAATCATAAT
+ATTAATGATGTCACCAGTGCCTGCACCAATAAAGCCTTTCACTTCTGAATTAAATTTAAT
+CACGCCAGAGCCAGCAAATGCTGCACCGCCAGCAATCATCATTTTCTGTGGCGTTAAGCC
+AAATTGAAAAGCAATCAGTCCACCAATAATTAAAGGGGTGGCTAGTTGGAAAATTTGCGC
+CGCATGAATAATCATTTCGATAATCTTGTATTCTGCAAAATATTTTAAAATGGCTCCTAA
+TACAGCATTGGGAATTAAGGCGATAATGGTGCCAGAAGCTGTTCCAGCTAACACTTTGTT
+AAAAAATATTCTTGGGGTTAATTGAGCATCCAGTTTATCAGTGGGCATTTTCAACACTCC
+TATTGATTATTTTTGTTTTTTTAGAACAAGTTTGAGAATGATTGAACTTTCTATTAGATA
+AAGAGCGGCCTCAAAGAAGAGCGCTTATTTCTTTGAGGCGCTTTTTATTTAACTAAAGCA
+AGGAACGATTTTTAATATACATCCGTATCCGCATTATATTTCGCTAAATTATCTTTAACA
+TCTCGCAAGAACTTACCTGCTTGTTGTCCATCTAAAATTCGATGATCAATAGAAAGACAT
+AAATTAACCATATCTGCCACTTTAAAGCCTCCATCTGCGGTTGGCACAAGGCGTTTATTA
+ATTGACTCTACTTGTAATATCGCAGCTTGTGGATGGTTAATAATTCCCATCGATTGGACG
+GAACCTAGTGTCCCAGTATTATTAAGAGTAAAGGTCCCTCCTTGCATTTCCTTGCTTGCT
+AGCGTTCCTTGTCGGACTTCTTGTGCCAAGCGATTGATTTCTTTAGCTAGCCCTGCAATC
+GAATAGTTATCCGCTTGTTGAATCACTGGCACGTAAAGATGCTCGTCTGTCGTTACAGCT
+ATGGATAAATTAACATCTTTATGATAAATAATTGAGCCATCATCCCAAGATGTATTGATT
+TTTGGATTTTTCTTTAACGCTTGAATGACTGCTTTGGCAAAAAATGGGAAGAAGCTTAGA
+GACAGGCCTTCTTGTTGTTTAAATTCATCTTTTAATGAATTTCTAAGTTGGACTAAGTTG
+GTCACATCCGCTTCCACCATTAACCAAGCGTGAGGGATTTCGTTGACACTTTGGACCATT
+TTTTTAGCAATCGCTTTACGTACAGGATCTGCAGAGACAATTTTATCTGGGCTTGTTTCA
+GTTGGACTAGCTGTTGCGGCGCTTTCATTTTGCGAAGCAACTGGCTCCTCTGAAATTGAA
+GGGCTAGTTCCTGGACTCACTGTTTTCTCAGGTGTTCTTCCCTGTGTTGGTGTAAAGTTT
+GTAACATCTTTTCTAGTAATTCGACCATCACGACCTGTCCCTGTAACTTGTGTTAAATCA
+ATCTTTTTTTCTTGGGCAATTTTAAGGACTGCTGGGGAATAACGACCATTATTTTTTTGA
+TGGGACGTCGCAGTGCTTGTTGTTGCAACCGTTTCATGTTCTTGCGCTTGTTCCGCACTT
+GCTTCTTTCACTGGTGCTAAAGTAGCTACTTCTGTTTTTTCGGTTGTTTCTTCTGTCTCT
+AACGTCATCACCGCTGTTCCGATGGGCACATCTGTATCTAGAGAAATCAGAAATTCTTTT
+ACTACACCATCAAAATCTGATGGGACTTCCGTGGTGACTTTATCAGAAACGACTTCCATT
+AAGGGATCATAGCGTTTCACTGAATCTCCTGGTTTAACTAACCATTGGACAATGGCTGCC
+TCTGTGACACTTTCGCCTAGATGAGGCATTTTGATTTCTTTTGTGGCCATTTATTTTTTC
+CTCCTTGCTTCAATTAAAATTCTGCTAATTCTTTCATTGCTGCTAATACTTGTTCTTCAT
+TGATTAAAAATTCTCTTTCTAAAGGTAATGCATAAGGCATGCTTGGACAATCAGGTCCTG
+CAAGTCGTTGAATCGGTGCATCTAAATCAAAGAGAGCATCTTCTGAAATCATTGCCGCAA
+TTTCACTCATCACGCTGCCTTCTTTATTGTCTTCTGTTACGAGTAAGACCTTCCCTGTTT
+TCTTAGCTGCAGCTACTAATGTTTCGCGATCTAAAGGATATAATGAGCGAACATCGACGA
+TTTCGGCATCAATTCCTTCAGCGACTAGTTTTTCCGCCGCAGCTAAAGCTAATTGCAAGG
+TCATGCCGTAACTAATCACGGTTAAATCACTACCCGTTCTAACGACATTGGCTTTGTCAA
+TTGGTACGATATAATCATCTGCAGGCACTTCATCTTTTAGTAAACGATATAAACGCTTAT
+GTTCGTAAAAAATGACTGGATCATCGGAACGAATCGCTGCTTTAATCATCCCTTTTGCAT
+CATAAGGATTAGAGGGGGTCACAACTCTTAATCCTGGTTGTCCACAAAAAACTTTTTCTG
+TAGACTGAGAATGATACAGCCCACCACGAACACCGCCGCCATAAGGGGTCCGATAAACGA
+TCGGCGCAGTCCAATCGCCTTTTGTTCTGTAGCGCATTGTCCGAGCCTCTGATAACAATT
+GATTGGTTGCAGGCAAAATGTAATCCGCAAATTGAAATTCACCAATTGCGCGATAGCCCA
+TTAAACCTAAGCCGACAGCTAAACCACCAATTAAACCTTCTGTTAACGGTGTATTAAAAC
+AACGCTCGTCACCGTATTTAGCAGCCAAGCCCTTTGTTACACCGAACACGCCGCCTTTGT
+CGCCGCCGACATCTTCTCCAAAAATAACTACTTTTTCATCACGAGCCATTTCTTCAGAAA
+TTCCTAAGTTAATTGCTTCTAAATAAGTCATCTCAGCCATTATATTTCTTCTCCTCTTCT
+CTTATTTTGCATACACTTCTTCTAAAATTGATGTCGGTACAGGATCTGGCATTGCTTCTG
+CTTCATCCGTTGCTTGATTGATTTCTGCACGAATTTCTTCATCAATTTTGGCAATGTCTT
+CGTCTGTTAAATAGCCCTCTTCTAATAATTGTTTTTCAAAAAGCTTCACTGCATCGTTCT
+TTTTCATTTCTTCAATTTCTTCTTTTGAACGATAAACAGATTGATCATCGTCAGCGGAAT
+GAGAAGTCAAGCGCGAAACCATTAATTCAATCAATTTTGGTCCTTTTTTCCCGCGAGCCG
+CTTTTACTGCTTCTTTAAATGCTAGATAGACTTCAGTAAAATCACTACCATCAACGGTTA
+CACCTTCAAAGCCATAAGCTTTCGCGCGATCGGCCATTCGTTTATTGGCATACTGTTCTT
+CAATTGGGACAGAAATCGCATATTCATTATTTTCAACAACAAAAATGACTGGTAATTTTT
+TTACGCCTGCAAAGTTCATAGCTTCTTGGACTTCTCCTTGATTGGCAGAGCCTTCCCCAG
+TGGTGGTCAATGCAACAAAATCAGCTTTTTGAAGTTGCGCTGCATAACCAACACCTGTTG
+CTAATGGCATTTGTGTACTTACTGTTGAAGAGAAGGAAACAATATTATGCTCTTTTGAAC
+CATAATGATTCGGCATTTGACGACCATGGGAAGAAGGATCCGCTTCTTTTCCAAAAGAAC
+CCATTAAAATATCTTTGGAGGTCATGCCCCAAACCAAGCACGCGGTCATATCACGATAAT
+ACGGTAAAAAATAATCTTTTTGAGGATCAAAAGCCATCGCCATCGCTACTTGTGCAACTT
+CTGCCCCTTGACCAGAAATATTGAAAGAGGTCTTACCAATCCTTGTTAATTGCCACAACC
+GTTCGTCTAAACGACGTCCTCGTAGTACTTGACGATATGCCTGAATCAATTCTTCTTTTG
+ATAAACCCGATTTTTTAAGCGTTTTCATTTTCATCAACCTTTCTCTATTTGTGAATCGCT
+AAGCCATAAGTATCTAAGGCTGCTTCTTGCAATACTTCTGTCATTGTTGGATGCGCATGG
+ATTGCTTCACCAATTTCAATGGGCGCGGCATCTAAATACATGGCAGTACTTGCTTCGGCA
+ATTAAATCCGTGACATGTGGCCCAATCATAGAAACCCCTAATAAATCATCGGTCTTCTTG
+TCACGAATTACTTCTATAAAGCCATCTGTTTCTCCATAAACAAGTGATTTACCATTACCA
+TTAAAATTAAAGGTGCCAATCACTACTTCTTTATCTGCTGGTAAAGTTTCTCTAGTATAG
+CCGACACTTGCTATTTCAGGATTTGTATAAACACCTCGAGGCACGTTTGTATAATTTAAA
+GGTTCAACTGTCTCGCCTAAAAGATGCTGAACAGCTAACTCTCCTTCTTTCATAGCCACA
+TGTGCTAGTTGGAGTGTATCGATACAATCACCGATCGCATAAATATGTCCTTCTGTGGTT
+TGATAAAATTCATTTACTTCAATGCCTTTGTCAGTATATTTCACTGAGGTATTCTGTAAC
+CCTAACTTATTGATATTGGGTTGACGCCCAATTGCTACCATGACTTTGTCAACAGCGAGG
+CTTTCTTGTCCTGCAACTTCTATTTGAACCTTCTGCCCGGTAACTTTCGCTTCTTGGACT
+TTGCTACCTAATAAAATGTTAATTCCTCGTTGCTCTAAACGTTTCTTTAATTCTTTAGAA
+ATTGTTGCACTCTCATTTATAAGTAACCGATCCAAAAATTCAATGATAGTTACGTTGACA
+CCTAAACTATTTAATAAAGAAGCCCACTCGACACCAATAACGCCACCACCAATAATTGCA
+ATTGATTCTGGTAGCTCTTCTAATTCAAGCATCCCATCAGAAGATAAGATAAATTCTTCA
+TCTAGTGGCAAATTAGGTAACGTTTTAGGACTAGAACCTGTCGCAATAATGACATTTTTA
+GGAACGATAATTTCTTCTTCCCGTGTTGGATCATTAAACGTAACTGCCACTGCGCCAGAG
+ACTGGTGAAAAAATGGAGGGACCTAAAATCGCACCTTCGCCTGCTAACATTTTGATTTTA
+TTTTTTTTGCATAAGCCTTCAACACCTTTGTGTAACTGCTCAATAATTCCTTCTTTCCGT
+TGTTGTATTTTAGAAAAATCAATGGACGCTGCCTCTGTTTCAATCCCAAAAGAAGCCGCT
+TGTTTTAAGGTATCAAAAACCTCTGCGCTTCTTAATAAAGCTTTTGTAGGGATACAGCCT
+TTGTGCAAACAAGTGCCACCTAATTTGTATTTTTCAACAATTGTGACGTTTAGCCCTTTT
+TGTGCGGCTCGAATTGCTGCTACATAGCCTCCTGTTCCGCCACCTAAAATCAGTAAATCT
+GTTTGTTCCGCCATTTTGATCACTCCTGCTCAATTTTTGCTTCACTATAATTTAAAGCTT
+GTTCTTCCCCTGTTAATACTCGATTGACGCCTTCATATAAAGCAGCCATCTCCATTTCAC
+CTGGGTAAACCTTAATTGGTGCAATCCAAGTGACTTTTTGACTAATTTCTTGAACAACGG
+TTTGCGAATAGGCTGCGCCCCCTGTTAAAATAATTGCATCAATTGTGCCTTCAAGAACCA
+CGGCCATCTCGCCAATACTTTTTGCGATTTGGTAACACATTCCTTTTAAATAGTAATTTG
+CTGTTTGATCACCTGCAGCTATTTGTGCTTGGATATGCCGTAAATCTGTTTCACCTAGGT
+ATGATTTAAGGCCGCTATTACCCGCAATTAGCTTTTTCACTTGGCTAATCGTTAACTCCT
+GTTCAAGTATCCATTGCGCAAATTCAACGAGCGGTAAGGCACCACTGCGTTCTGGCGTAT
+AAGGACCTTCACCATCAAGCCCATTTACCACATCCACCATGCGGCCTTTTTGATGCGCCC
+CCAAGCTAATGCCCCCACCTAAATGAACAACGATAAAATTGCTTTGCTCATATGTTTTCC
+CTAAATCCTCAGCGATTTTTCGAGCGACCGCTTTTTGATTTAAGGCGTGACCAACGCTAC
+GCCGGTGAATGCCTTTTAATCCGGAAATCCTGGCTAATGGTTGTAGCTCATCTACAACAA
+CAGGATCGACAATAAAGGCTGGCACGTGATATTTTTCTGCAAACTCATTAGCTAAAATCG
+CCCCTAAATTTGAAGCATGGGTATTAAAGCGTTCTGTCCGCAAGTCTTCTAGCATTTGTT
+GATCGACAAGATACGTACCGCCAGGAATAGGCTTAAGCAAACCACCACGCCCTACGACAG
+CGGCTAATTGTGTGATGTTATGTGTTTCTAAAAATTCCGCGATCATTTGTTTTCGAAATG
+GTGTTTGACTGACAACATTTTCAAAAGGTGCCAATTCTTGGACGCTATGTCTAAGCGTTT
+CTTCCGCCAAGCAATCATGATTAGCAAAAAGCGCTAACTTCGTGGAGGTCGATCCAGGAT
+TAATAACCAATACTGTTTCCATTGTTTTCTGCTCCTTTTTTTAAACTTGTCTCATGGCAA
+ATCTTAATGAATGAAATTTGCTTTCTGTCGAATCACTTCTAGATGTTAAAACGACTGGGA
+CTTTTGTGCCAACAATCGTTCCTCCCACCTTTGCGTGCCCAAACAAGGTTAATGATTTGT
+ATAAACAATTTCCAACATCAATAGTTGGGACCACTAAAATATCTGCATCCCCCATGATAG
+GACCGCTGTAACGTTTATGCGCAACCGCTTCTTCAGAGGTCGCTAAATCAAGCGAAAGTG
+GCCCAAAAACCGTAGCCTCTTGTTGATCATTAAAATGTGCCGTGACTTCTTTTGCTAAAA
+CAGACGAAGGCATTTTAGGATTGAAATTTTCCGCTGCGCTTAACAAAGCAATTTTCGGAT
+GATGCAGTCCCAATTTTTGGGCGACTTCTTTAGCATTTTCAACAATTTCAATGAGGGTCG
+CTTGAGTGGGGGCGATATTCATCGCACAATCGGTTAACAAGAAGGTTTTTCCCGCAGGCA
+GCTCCACCATTGCTACATGGGAAAGAATCGGTTTATTTTTTAATTGATGCTCACTTTTCA
+ACATTTCTTTTAGTAATGTGTGAGTCTGAATAATTCCTTTCAATAAAATTTGTGCTTGAC
+CGGTTGCAACTAGACTGACAGCTTCCTGTGCTACCGCGGCCTCATCTGAGCAATGAACAT
+ATTTCCAGAGATTTTCAGTATCAAGATTTTCATTTGTATCAAATACAATAAACTGCAACG
+GTTGCTCGGCTTCTTTTAGCGCTTTTTTAACTAGCTGTAAAATCTCTGGTTGTGAACCTC
+CTGCAATTGAAACAGTGATCATTTTCTCACCTCATTTTTCTTCTTTACACTTTAAATCTA
+CCTCAGTATGTAAGCGCATACAAATTGTTAATTTTTATGTCCTTATTAATATTTTTTATA
+GAGAAGGAAAAGCTTAGTAAATCAAGCTTTTCTTTCTCTAAACAATTGTTATCTAATTTA
+CTTTTCATGAAAAAACTTCTTTTCTAAGAATGAAAGGAAAACTTATGCTTCGGCACAGCT
+GTTTATTTATGTCAGATTCTAAAGCATGTTATACTTTAGATACTTATTTTTAGGAGGAAT
+TAAATGGCACTACTACTATTCTTTTTGTTTATCGCCCTACTAGGATTTGGTATATTAAAA
+ATTAATAACCGCAGTATCCTCGGCGGTATCACTCTGGCTTCCGGCACCTTATTGTCATTA
+GTCACCTTACTATTTATCGGACTAGACAAAATTTATTTACATTTTAAGAATGGCGACCTA
+ATTACCTTGGCCATTGCTTATCTATTAATTCCCGCTGTGTTTATCGGCATTTGCCTTTAC
+TTTATTTTTAACTCACGTACGATGCAAACGAAAGAAGGCAAAAGTGTCACGGCTAAATTG
+TCGGCGGGCTTAGGGTTGAACTTATTAATTGTTTTACCAGCCTTTCTATATTTATTATCA
+GTTGGCACAGCGCAAATACCTTATGTGCTTTTTCTGTTCTTACTTTTTCTATTGTTAATG
+GATCTTTTGCTGACCTTTCTATTTGCTGCTTACGTCTTGTATTCATGGATGTACCAAATG
+ATTCCTTTAAAAAAAGCGGTTGATTATATCATTGTTTTAGGTTCGGGAATTCGTAGCGAG
+GAAGTACCTCCACTTTTGAAGAGTCGGTTAGATAAAGGGATTGAATATTATGAAAAAAAT
+CCCACCGCTAAATTTGTAGTCAGCGGTGGTCAAGGTCCTGACGAACCTGTGGCCGAAGCT
+TTCGCAATGAAAAAATATTTGCTTTCACAAAATATTCCTGCAGAAGCAATTTTGATGGAG
+GACCAATCCACAACCACTTATGAAAATATGTTGTTTTCTAAAGCAATAATTCAGGCAGAT
+TGGCAAAAGATGCCGTCTGATTCTAAACAACCCTCTGTAATTTTTTCAACAAATAACTAT
+CATGTCTTACGAGGAGCTATGTATGCCCATCGTGTCGGCTTAAAAGCTGAAGGTGTCGGG
+GCGCCAACTGCCTTATATTTTTTACCAACTGCTCTAATCCGAGAATACACTGCCTTACTG
+GTTCATGATAAGCGAATTGTGCTTTTTGTTTTTCTACTTGTCACTCTTCTTTTAGGAATC
+AGTATCTTACCCATCTAAAAAAACAGCGACTCACATTTTTGTGAGTCGCTGTTTTTATTC
+TTTTAATATAAAAAGGTTTAATGAACGTAATTGGCTATCAATGCAATCAGCCATAAATGA
+AGCGGATAGAATCCGTAAAATAAATATTTGAAAAATGGTGCTTTGCTCCCTCTCTCACCA
+TTGTAAAGCGATATAAATGGTAACACAGTGATAAACATAAAATCAGAATTATAAGCTAAC
+ATTTCAATTGTCGTTGGCCAATCTCCCAACCATTGAAAACTTGTAACTAAGAAAAAGAGC
+GCTAATGCACCATATAAACAGTTCCGTAAGACAAGTCTCTTTCTGGCAAGATACGTAATC
+AACATAAAAGGTAACATCACAACGCCACCTTCAGCAAACATTGCTCCTATTCCTAAAATG
+GCTAATATACTAATCAATAAAACAATTTTTAAACTGATTTTTGGCATCTCTAGCATCGCT
+TTTGTCACAATTAACATACTGACACCAAGGGCTAAGGTGAAGAAAATATTGTTGTGAACA
+GCGACAGCTGGATTATTCACTAAATGATTTAGAAGCGTATTTCCAACAAACATGATTGCT
+GCCCAAATATACAAACGACCATTGTAACGATAAATATTCCGTGTATAGTTGAACCCTTCT
+ACAGCCATGTAACCAAAAAACACACCGACACAACGAGTAATTACATGAAAAATCAGTGCC
+CATTCTGGCGGAACAAAATAACTAATATGGTCAAGAACCATTAACCCCATCATCAATAAT
+TTTAAGCGATTTGCGTTCATGAATCGTCTCCTTTATTTTTTCTACAGAAACTATCATATC
+TTTTTATATAACAGAAAACAACGAACATTCTTGTTAGATTCAACCATTCTTTTTGTCACT
+TTTGTTAAACTTGGTACCGCAAAGATAAATCTTCAAATAAATAATGCTGGTATTTAAATT
+GTTCAAAATGAATTTTTCGAATTTCTTGCTTAATGGCTATTAAGCATTCATCGACCGTCA
+TCAATGATTCTTCTTTCAGAAGCGCCTCTTCTATTAATAATTTGCATTGGCAGTCAATCA
+ATAAAAGTTGACTATAGAATGTGTAAAATGTTTCTTTATTTAATTTTTCAATCAAATTTT
+TAGCTTGATTCTGCAGCTTTTGATAACATTTGGTCAATTTTTGATAATCCATTAAATCAA
+CTAACTGACCTTGTTTTAACATGTTACTAAAGTCTAAATCCCAAAGCATTTCTTTAGTCG
+GCTGTTGCAATAAATAATACATAGAATGACTACTAATAATTTCAGTGGTCGGTTCTTCAA
+TTGTTTCATAAAAAGTCACAAAATATTCTCGCTCAATCACAGTAATAATTTCTTCTTCTG
+AAAGCTCACAATCTTCTAAATTTTGATAGAATATCAATAATTTAATCCGCTCATCTATTT
+TATTCAGCGAAGCGACTAATTCAGGAAAAAGAACCGACTGACAATTCTCTACTAATTCTC
+TTGCCTTATTTTGTTCATTTTTATAAAAGCTGTATAACTTTTTCCGCTGTTTTAACGAGT
+TTAATAAGTTATCGGGTATATTCCAGTAATATTGTTTCTTCATAGCATTCCCACTCTTCT
+TTTTTATGTACAATTTTACAAAATTGGTCTTAGCCAATTTCGTCTCTAGTTATTCTATCA
+AAAAAGTGACGCTTTTTTACTGACAATAATTACTCGTTTTACGCCCAAAAAGTGAAAATC
+TAGCTGTTAAGTAATTATTGGGGCTTGTTTCCCGCGGGCCGAAAAAACTTTTTCCTTTTA
+AAAGTCCAGAAAAAGACCTACACTAGAGATAGACAAACGTTGGAGGGATTTAAATGGATT
+TACACTTAACGAATAAATTAGCATTAATTACTGGTTCAACCAAAGGAATTGGCAAAGCAA
+TTGCGATTGAAATGGCTCGCGAAGGGACCGATGTCATTATCAATGGGCGTAATGAAGCCG
+AAGTAATCAAAGTTGTTGAAGAAATACAAACAATGTTTCCAGACACTCATCCTCAAGCAG
+GAACTGCCGATATTTCCATTGAAAGTCAACGAACTACTTTGCTTGAAAAATTCCCTAAAG
+TCGACATTTTAGTGAACAATATGGGGATTTTTGAACCAATGGAATACTGGGACATCGATG
+ACGCCACTTGGGAAAAATTTTTTACTGTGAACGTGTTGTCAGGCAATGCATTAGCAAAAG
+CTTATCTACCTAAAATGCTTGCACAAGATTTTGGTCGCATTATTTTCATCGCTAGCGAAG
+AAGCGGTGATGCCTTCTGGCGAAATGCCCCAATATAGCATGACAAAAACGATGAATCTTT
+CCTTAGCTAAAAGTTTATCCAACTTAACTGTCGGCACACATGTCACCGTTAACACGGTTA
+TGCCTGGCTCAACCCTTACCGAAGGTGTAGAAAAAATGTTGGAAGATATGTACGCTGATT
+CAGACATTCCCAAAGAGGATTGGGAAAAAGATTTCATGAAAAATCATCGTTCTCGTTCAC
+AAATCCAACGGCTCATTCGTCCAGAAGAAATTGGTCGTTTTGTTACCTTTGTGGCCAGCC
+CGGATTCTTCTTCCTTCTCAGGCGAAGCCTTAAGAATCGATGGCGGCTTAGTTCCAACGA
+TCTTCTAAATTAAACAAAAAAGACAGCCAGCAAAAATTCACATTTTTTTGCTGGCTGTCT
+TTTTAAGCATATTAATTGATTACTTACCAAAAGTAAGTTATATTTATCTCGAATTCGAAA
+TAAAAAGAGGTGAAACAATGAACCAACAGCAAGAAGCTTTAAAAGCCTATATCGGTTTAT
+TAAGAACCAGCCATCGACTAGAGCAACTTGCCAAGCAAGATGTTACTTGTTATGACTTAA
+ACATTACAGAATTTTCAGTGTTAGAGCTGTTACTCCATAAAGGTCCTCAGACCATCCAAA
+AAATCAAGGAGAAAATTTTAATCGCTAGCAGTAGCACCACTTATGTTATTGACCAATTAC
+ATAAAAAAGGCTATGTAACGCGCACTCCCAGTGAAAAAGACCGACGCATTACTTACGTCG
+AATTAACAGAAGCTGGAAAAACATTAATTAAAGAAATTTTCCCGACGCATGCAAAGCGAA
+TTGCAGAAGCATTTGAACAACTCTCTTCCGAAGAATTAACACTTCTTCAAAAAACTTTAC
+GAAAAATAACAAATGAAACGAAATGAGGAAATAATGATGAAAAAAGAAGATCAATTATTA
+GGAATCCACCACGTTACAGCTATGACAAGTGATGCAGAAAAAAACTATCACTTCTTTACA
+GATGTTTTAGGGATGCGTTTAGTCAAAAAAACAGTGAATCAAGATGATATCTATACTTAC
+CATACCTATTTTGCTGATGATTTGGGTACACCAGGTACAACCATGACCTTTTTCGATTTT
+CCCAATAACCCTAAAGGATTAAAAGGAACCAATACAATTTCAAGAACAGGGTTCCGGGTT
+CCTTCAGATGCAGCTTTGACTTATTATGAAAATCGCTTCAATGAATTTGCTGTCAAACAC
+ACAGGTATTTCTGAAGAATTCGGGAAAAAAGTCCTTCGCTTTTGGGATTTTGATGATCAA
+GCGTATCAATTAATCTCTGATGAATTAAATCAGGGCGTTGCAGCGGGCACCCCTTGGAAA
+AAAGGACCTGTTCCAACAGAATTTGCGATTTATGGATTAGGACCTGTCGAAATAGCTATT
+TCCTATTTTCATGAATTCAAAGAAGTCTTTGAAGAAATTCTAGGCTTTCACCTAGTGGCA
+CAAGAAGGCAATCGCTATTTACTAGAAGTTGGCCAAGGTGGCAATGGTGCCCAAGTCGTT
+TTGGTAGACGATGATACTAGCTCACAAGCGCAACAAGGATATGGTGAAGTACATCACGTT
+GCATTCCGCCTAGCGGATCGTAAATCACTTGGGACTTGGCAAGCGCTCTTTGATCATTTA
+GGCTTACAAAACTCTGGCTATGTCGATCGTTATTACTTTGAATCATTGTATGTTCGCATT
+GGACATATTTTAGTCGAATTAGCCACCGATGAACCAGGGTTTATGGGGGATGAACCTTAC
+GAAACATTAGGAGAAAAGTTATCTCTTGCGCCATTTTTAGAAAACCGTCGTGAGTATATT
+GAGAGTGTTATCAAGCCTTTCAATACAAAACGAGCCTAAGGAGGAAAAAAAACATGCATT
+CAATTTTAAAAAAAGGACATCCTGAAGCACCTGTCTTTGTGCTACTTCACGGTACAGGTG
+GTGATGAAACATCTCTCCTACCAATTGCCCAAGAACTAAATAAACAAGCTACTGTGCTAA
+GTATTCGTGGTGATGTTTCAGAAAATGGAATGAATCGTTATTTTAAGCGCCTAGCGGAAG
+GTCATTATGACTTAGAAGATCTAGAAAAACGCGGCGAGGCGCTTCATAAGTTTATTCAAC
+AAGCCGCTAACGAGCATCAATTTTCATTGGATAAAATTATTTTTATTGGCTATTCAAATG
+GGGCCAATATCGTTATTCAATTATTGCTTACTCATCCCGATAGTTACCATCAAGCTGTCC
+TCTATCATCCCATGTTTCCTGTTGAATTGACCAATCAACCAGACTTGACCGACACTTCTG
+TTTTATTATCTCTAGGAGAGCATGACCCGATTGTTCCACTTCCTGAAAGTATGCGTGTGA
+TTCAATTATTTCAGAATCATGGAGCAACCGTACAAGAGGTTTGGACACAAAGTCATCAAT
+TAACTTATCAAGAAATTAAGGAAACACAAACTTGGTTGGCACATCTGTCCTCTTAACAAA
+AAAGTGGGTCCTAAGTCGAAATGACTTAGGACCCACTTTTTCTATTTTAAGATAACTCAC
+TGTCTGAGCTTCTTTTTATTCTGCCATTTGAACAACTATTTTACCAACTGCATGGTGCGT
+TTCACTGAGTGCATGTGCATCATAAATCCCTTGTCTAGAAAAAGGGAAAACTTCACCAAT
+AATTGATTTCACTTTTCCAGCTGCCATCAAATCAGCAATTTTTTGTAATTGTTCTCCATT
+TGGTTGAAGCCAAATACTTTCAGCAGAAACATTTTTTTCGGCTGCCAATTGTTTATCTTC
+AATGCCCACAATTGAAACAAGACGACCTGTGTTTGGTTTTAAGACGGCAAAACTATTTTT
+TTGAACCTCACCACCCATTGTATCAAAGACCAAATCAACATCAGCTAATACCTCTGCAAA
+ATTCGTTGTATGATAATCAATCACTTCATCTGCACCAATTTTTTTCAGTAAGGCATGATT
+TTTGGCGCTAGCGGTCGTGATGACATGTGCGCCCGCTTCTTTTGCTAGTTGAATCGCATA
+AGTACCGACCCCACCTGCACCAGCATGAATTAAAACAGTTTCTCCTTCTTTAAGGTGACC
+ATGATCAAACAATGCTTGCCAAGCGGTTAAACCAGCCAACGGAACGGCAGCCGCTTCTTC
+AAAGCTAATTGTTTCAGGGATTTTTGCTAATAAATGATCATCCACAATCGTTACTTCTGC
+ATAGGTACCAAAACGAGTAGTTTCAGGACGAGCAAAAACTTTATCGCCAACTTGCCAATC
+CGTTACTTGACTCCCCACCTCTGTAATCACACCAGCGACATCCCAACCAAGAATAATCGG
+AAAGGACCAATCAAACATCTGTTTTAAATATCCTTCACGCAATTTCCAATCAATCGGATT
+AATTGATGTCACGTATTCTTTTACCAACACTTGATGTTCCGATAATTCTGGCAGTGTTAC
+TTCTGCTTCTTCAAGTACCTCTTTACTTCCGTACTGATTAATCACAACAGCTTTCATAAA
+CCAACTTCCTCTCATTTGTTTCATTTTTCACACTTTTAGTATACGCCTATTGCCTTCTTT
+TTATATAAGAATATGCTTTAGTTAAATTGAGAGAAAGTAGCTGTTTTTAGTCTATTATTC
+ATAACGTAAAGATTCAATTGGATCTAATTTTGCTGCTCTTCGAGCTGGTAAAGTTCCTGC
+TAAAAAAGCAATAAACATAATAACTAAGATAATCGTTAGTGAAGATGGCAATGAAAATTG
+AATTAATTTAAATCCTGTTAAAGCCTTTAAAAAAGAATCCGTTGCCAAACGATTAACTAA
+ATTTCCAACCCCAACAGCTCCTAAAATGCCTAATATTGAGCCAAAAAAGCCAATTAAAGC
+CGCCTCAACACTAAAAATTGTAAAGACTTTCCCATTGCTAAGTCCCATGGCTTTCATTAA
+ACCAATTTCTCGCGTTCTTTCTTGGACAGACATATACAGCGTGTTAATAATGCCAAAGCT
+TGCAGCTAACAAGGCAATTGCACCAAACATGGTTAAGACACCAGTGATTGCATTGATTAT
+ATTACGAATCATGCCAATTTCATCTTCGACAGTAGTCGCTAAATAGCCAGCTTTGTCTAA
+ATCTTTTTTGATGTCCTTAATCTGCTCTGGCGTGCTGTCTTTTTTAACTTCAGCAATAAT
+CATCGCGTATTGATTTTTTAAATGTTCTGGAAGATCTGCTTGATTGATTGAGACAACTTT
+ATCAATCAATGCTTTATTCATCAGCGAGAGCCCATTTTGAATGACACTGGCATTTCTAAC
+GCCAACAATTTTTGCTTCAATAACTTGCTCTTGTCCTTTCAAGGAACTTGAGATACCTAA
+TTGAACTGTTTCCCCCACGGCAGCTTTACTAGATGTATAGCCGAGCGCTTTTACATATTC
+TGGTGACAAATTAATTTCGAAGTCCTGGCTCGTTTGCGAAACTTTACGGCCAGCCGCTAA
+ATCAATGGTCATCTCATCTAGCGCAGAAGTTGCTGAAAATACATATTTATGCTTATCTGC
+TCCTTTTATATAATCGATAGCAACGGATTTCATTGGTTCCACTGATGTAACATCCGAGAT
+TTTTTTAATCTTCTCAATATCTTTTTCAGCAAGCATACTTTGTTGTTGAATCGTACTGGT
+TTTTTTCTCTGGATTATATTTACTTGGTTCTGTTCCGTTACCAACATTCATCTCCATTTT
+TGGCTGAATAAATAACTGATTTGCACCACCGACACTGCCGACTTGTTTGTCAATATAATC
+ATTTACACCAATATTGACTCCTGTAGTTAAAGCTATGGTAAATGCTCCAATAAAGATTGC
+AATAATGGTCAATACGGTTCGACCTTTATTACGCATTAAATTGGTACTAGCTGATTTTAA
+AATATCTCTAAATTTCATTTACTCATCTCCTCCTACAATCAAGCCGTCTCGAACATGAAC
+TTGCCGATCACAACGTGCTGCTAAGTCTGGATCATGTGTCACAATAATTAAGGTAATTCC
+TTTATTTTTATTTAAATCAAATAACAATTCTTCAATTTTCTTCCCAGTGGCAGAATCTAA
+ATTCCCTGTAGGTTCATCTGCAAAAATAATTTGCGGATTATTAACTAAAGCACGCGCTAT
+ACATACCCGTTGTTTTTGGCCACCAGATAAATTATTCGCTTTATTTTGAACTTTATCTTC
+CAAACCGACTGCTTTTAACGCATCTAAAGCCATCTTTTTCCTCTTGCTACCGGAAATCCC
+ACCAATTTTTAATGGTAAAAGAACATTATTTAAAACTGTATCCTTGGCATTCATAAAGAA
+TTGTTGAAAAACAAAACCAAATTCTTCATTTCTCGTTTTATTCAGCACTTTCTTTCTAAT
+ACTAGTAACATTTTTACCATTTAAATAAATATCTCCTGAAGTTGGTTGATCTAACAATGC
+CAAAATGTGCATAAATGTTGATTTCCCAGAGCCACTTTTACCAATTATGGCCACAGATTC
+ACCTTTTTCAACTTTTAAATCAACACCTTTTAACGCATCAAATTTTGTTTCGTTCTTTCC
+ATAACTTTTTTTGATATTTTTTGCTTCAATTACCGCCATGTTACCCCTCCATTTTTCATT
+CTTTGTCGTTTACTTATTTACAAAGTTTTTTACTCTTTTCATACTCCTTTCTTCTCTTTC
+TATTTTGACGGAAGCCCTTTCCTTTGTCATGGTAATTCCGATGTATCTCTCAATTAAAAC
+AATAAGAACATGTTCCAAATTCACCTCATTGAACATGTTCTTATTAATTAGTTATGCATT
+TACGCGTTTAATTTCACGATGTTTATTCAATAAATAGGCCAAACCAAGATTAATGCCAAC
+AAAGCAACTGATTGTCAGAAGAAGTGGTAGGACAGTAAAACCAGTGGATTGATAACCAAC
+CATTGCTTGCAAGACATGGAGCATTCTCAGGCGCATTGGTGCCCCCCCTAATTGTGCAAT
+CGTGCCCAGTAAAATAGGAATCATTAATAACAGCAATAAAACAATGAGTTTTTTTACGCC
+ATCTATCCGATCATTAAAGACACCTGCTAACAAGCCAAGTGAGCCGCTAAGCATTAGTAA
+GATAAAAAAGAGCAACCACGACATGAAAAAGTTTCCTTGCGCATAGACATCAATTAATTT
+CATTGATAATTGAAAATGAGAAATGAAATTGCCGCTAAATACTTTAATCAGTACAAGTAC
+AGCCAAGGATCCAACCAAAGATAAAATAGCATTACTTACAAAATTCACCAAAAAAATTGT
+CCAGCGGGAAAGCCCGTTTTGAATAAACAGTTTAAAATCTGTGTTCATTCCCAAAAATGA
+TAGTATCCCCATAAAAACCAGACAAGGAATTACTGCATCAGAGCTGACAGTATTCACGTC
+GTTAGAAAAGAGCAACCCAATAAGAGGAAAAAGAATGCCGAACAAAGCATAAAAGCCAAA
+ATAAATTGCTAAGGAACGGACTTGATAAATAACACGATACCGCAAAGCTGTTTTAAATTT
+CATTTTACTTTTCCTTCTTTCTATTGGTTAATTGCACAAAATATGTTTGTAAATTTAGCG
+GCGCAATTTGAACCTCTGCTTTTTCAGTCGGCAAGTCGCCGTACACGTAAGCCGTAACTG
+CCCCACCTAAAGTGTCCATGCCTAAGATTTCCAATGACTGAGTATAGCGCTCTACTTGTT
+CTTTCGGCCCAGAAACAATGCGACCGTTTTTCAAAATTGTTTCAATAGATTCTGCGCGAA
+TCAATTTTCCTTGATCAATGATGATAATATCTTCTAATAAATTCGCAATTTCTTCAATCA
+AATGGGTGGAAATCACAAACGTACGGGGACGTTCTTGGTATGTCTCAATTAAATAAGTAT
+AAAATAATTCCCGATGATTGGCGTCTAAACCTAAGACTGGCTCATCTAAAAAAATATACT
+CACAGGGGACGGATAGCGCCACTATTAGTTTAGCAATACTCCGATAACCAGTTGATAATT
+TTTTGAATGTCTTTTTACCATCTAAACCAAAATCGCTTAACATTTGTTCGGCTAAAGACC
+AGTCAAAGGATCCATAAAAACCTTCAGTCGTTTTAAAAATATCTTTAATTTTTAACTGAG
+GAGGAAATAAATTATCTTCACTCATTAAGTAAATATGATTCAAAGCAGTCTCATTATCGG
+TCACTGTTTCTCCCGCCAATTGAACGGAACCTGAAGTGGCAAAACTTCGATTATTAATGA
+TATTTAATAACGTACTTTTACCAGCCCCGTTTCTGCCTAAGAGCCCATAAATCGTTTCTT
+TTTCAAAAGTAATTGAAATATTATCTAGTGCTTTTTTTTGATGATATTTTTTACTTACTG
+ATTCCACCCGCAAACTCATGCGTCATACCCTCTTTCAATTAGTTGTTTTAATTGTTCAGC
+TGTAATTCCTAATTTTTTAGCTTCTGCGACAACTTCTAAGACTTCTTTATTTAAAAATTC
+TTCTTTCCGTGCACTTCTTACTCTCTCTTGAGCGCCTGGTAAAACAAACATGCCAATCCC
+CCGTTTCTTTTCAATCAACTGTCGTTCTACTAATAAATTCATTCCTTTTAAAACGGTGGC
+TGGATTGATTTGATAACTTTTTGATATTTCTGTGGTTGAGGGAATTTGTTCGCCTTCTAA
+GTAAGCGCCATTAAAAATTCCTTCGGCAATCTGATCGGCTACTTGCTGAAATAAAGGCTT
+TTCCCCCGAAAAATTAAATTCCATTTTTACACCTCGCTTAAATAGTTAACTACTTATGTA
+ACTAACTATATATCCTAGAAATTCTTTTGTCAATAAAAAAACCATTGTTTCCAAAGAAAT
+TTTTCTTTGGAAACAATGGTGATACTTTTGAGTTTATTGAATGATTTCGTTCTTATAGGG
+TTCCATTGTATAACAATTCATCGGTTGTTTCGTTGACAATTTTTAAGCGATTTTGTTTTT
+TTATCAAAATACTTTTATAGGTCGTTCCTGTAGCCTTTTCTTCCATCACAAGAATGCGTT
+TATACTCATTATCAGTGACTTTCTTAATCGTTGTTTGATTTAAGGACGGAATTTTTTCTT
+TTAGCGTTTTTTCTTCCGCCAGACCTTTTAAGATTTCTGATTCTGTAGTGGAACTTGTGG
+GTTTATTAGAATCGCTTGATACACCTTCGTTATTAGACGCACTTTCAGATGACTTGCGAC
+TTGATTCAGTTACTTTAGGCTGTGATGATTCACTGGTATTGGTTGAATTCATTTGAGTTT
+GGGTTTGATTCCCACATGCACCAATTAGCAACCCAACGCCTAAGATAGAACTTGCTAAAA
+TTGTTTTTCTAATCATTTGCATGACCTCCTACATCTATCATTACTTTAACCTTAACATTT
+TTCAGCTAAGAGAACAATTTTTCAGATTAGAAAAGACCACTAGTCGTTATTTAAATAAAC
+GAACTAGTGGTCTTACTTATTTAGGAATGATCTTCATATGAGTGAGTGGGTAATAAACAA
+ATTGTGCTTTCCCTAAGATTTGATCTGCATGTATTGCACCAAAAGAACGGCTGTCTTTGG
+ACATACGGCGATTATCACCAAGCACAAAATAGCTATCTTTAGGTAATTTTTCTTGCATTA
+ACAATTCTTTTGAATCAAAATTCGTAGTATAAGGCATCGTTTCATGATCTTTTTTTCTGT
+TTTTAGTTAAATACGGTTCAGCGATTGGCTGATTATTGACATATAATTGATCGTTTTCGT
+AACGCACAGCTTCTCCTGGTAAACCAATCACACGTTTAATCAGAATCGATCCTGTGTCTG
+TTTTAAAGACCACCACATCAAACCGTTTAATGGCGGAGAATTTTTCCATCACAATCATAT
+CTCCTTGATTCAAGGTTTTTTGCATAGAATGGCCATCCACCCGAACAGGAATCAGGAAAA
+ATCCTCTTAAAATAAAAACGGCTACGATTGCTGGTACTAAAATTTTCAGAAAGTACATTA
+AATACCCAACATAATCACGTTTCTTCTTCAACTTCGTGCCACCTTTTTTCTAGTTTTTTT
+GAATTTCTTTGACTGCTGTATCGTAGGCAGCGTCATTTTCAAGAATTAATTTACCTAAAG
+TGGCTTCAATTTTTGTGGCTGTTTCATTGTCGATTTCTCCAGTTACAGGCAAGCCATTTT
+TCTGTTGAAGATCGCTAACCGCTGCTTTTGTTTCTGCGGTGTAGTTTGCATTGTTTTCAT
+CAATAGGATACGCTAATACAGCTAAAATAGCATTTAAGTTCTGAATATCTTCAGATTGAT
+CTCCTTCTTTTAGCGTTTTATCGCGAGGAATCAATTTTAAATAGGCATACTCGGGGTAAT
+CAGCTTTGATGGTTGGTTCAATTCCTTTTTCGTTGATCCATTCACCTTTTGGTGTTAACC
+ATTTTAAAACAGTCAATTTTATTTCGGTTTGGTCATTTAAATCTTTCACCGTTTGGACCG
+TTCCTTTGCCAAATGTTTTCGTTCCAATTAGTGGGACATTCGCAGATTCATGCAGTGCTG
+CAGCAAAAATTTCGGATGCACTGGCACTATTGCCATCAATGATAACTGCAACAGGTTCTT
+TTACTTTAAAGCCGCCGTCTAATTCTTTGGAAGCAACTTCTTTCATCGTACGTCCTTTTT
+TGTCTTCAAATTGAACAATTGTTTCGCCATTTTTTAAAAACATACTGGCCATTCGCTCTG
+CTTGATCTAGCAGTCCACCAGGATTTTGGCGTACATCAATTACAAAGGATTTAGCTCCTT
+TTTTACGTAAATTCGTGATTGTTTCTTTCAATTCTTGATATGTTTTTTTACCAAAGGACG
+TAATTTTAATCGAGCCAATTTGTGCATCTTTTTTGTCTAACTCACCTGTCACTGTTTTAA
+CGGGAATTTTCCCACGTTTGATTGAGATATTTTTAGTTTCTCCCTCTCTTTGGATTGTCA
+ATTCAACGGAAGTTCCTTTTTTACCTCGGACTTTTGAGACGACTTCTGCTAGTTTCATCC
+CTTTTGTAGCTGTACCATCAACTTTTTCAATAATATCGCCTTCTTTGATTCCCGCTTTTT
+CAGCTGGGGAATCTGCTACAGGGGCCTCTGCTACAACTGGTTCGCCATCTTTCATTGTCA
+TAGTGGCACCAATTCCTTCAAAATTGCCAGATAAGCTTTCATTTAAATCATTGGCAGCAG
+ATTCATTTAGATAAGTTGAGTATGGGTCTCCAATGGCTTCAGACATGCCTTTTAAGGCGC
+CTTCAACTAATTCATTTTTATCTACTTCACCTACATAATTGGTACTAATTTCATTATATA
+AATCCTGCACTTTGCTTAAATCAGCATTGGTAATTGCCCCTTCTTGACTCATCTTTTTAA
+CACGATGATCAAAATAAATATAACTACTTCCTCCAGCTAAAAATGCGACACAGAGGAGCG
+AAATAATATATTGATAAAAAGGAACAGTTCGTTTGTTCTTCATAGATTTCATCTCATTTC
+TAACAAATTCGTCACTACTTTTGTTTACTATAACATGAATGAAAAAAGAGGAAAAGCTTT
+GTTTGCTTTTCCTCTGGATTTATTTATTGTTTTCAAGGTACTTTTCCCATAACTCATCAA
+AGATGTCCATGTTGCTTAAATAGTCAGCATTCATTTCTAAATAAGAAGAAAGTTCATGAT
+AATCCTCGGTTTGTTTTGGAAACTGAATATCTTTGGCCGCTTCATTGGCAAAATCAGTTT
+CAGGATCTTTAGCCGGACCTTTTAATGTCATTAAGTAATGGTAAAAGCTTCGTCTCATGT
+AAATTAATCACTCCATTTTTCTTCGATAAATTCACTTCTACGTTGATGGGACAATCCATA
+ACGCAAAGCGTCTTTTTTATAAAAGTCTTGATGGTATTCTTCAGCAGGATAAAATGGTGC
+TGCTGGTTCGATGGTGGTAACAATTGGTTCTGTAAAACGACCACTATTAGCTAGACGTTC
+TTTACTTTTCTCAGCAATTTCTTTTTGTTCTTGGGAACGATAAAAAATAACTGGCCGATA
+ATTATCGCCGCGGTCTTGAAACTGACCGAAAGCATCAGTAGGATCTGTTTGTTGCCAATA
+AATATCCACTAATTGTTCGTAAGAAATAATCGCTGGATCAAAAGTGATTTCTACTGCTTC
+CGTATGGCCTGTTGTGTGTGTTAGAACCTGTTCATATGTTGGATTAGGCACGTGCCCACC
+TGTATAACCCGAAACAACTGAGATAATCCCTGGTTGTGTATCAAAAGGCTGCACCATACA
+CCAGAAACAGCCGCCTGCAAAAATTGCTTTTTCTTCCATCTCTAACACTCCTTTTTTATT
+TCTCTTTTGGCAAGTATATATTCATCCGAATGTCATCGTCAACTAAATTAATCTTTTCTG
+CTCGAACAAATAGACCATTTTGCATTCTAAACTGATCTAAACGTAATAAAACAGTTTGAT
+CATCTGGATTGATTTCAACCCATTTAGGTAGTTTGTAAGAACGTTTAGCAAATTTCAATA
+CTTCTTTAATTGGCAAGCCTAACGTTCCTATAGATAAACTTTTTGCTTTTAATTGTACAT
+TACCATTCGCCATCACGTAAGGATCAAAATATAAGTAAAAAGGAATGTCATGCCCTAACA
+CCTGAAATGTTCCATTTAATAAAGCATCATTTTCTAAATAAAATTTATATTTAATCTCCG
+AGCCTTTTTGAAAGTCGGCTAAATAAAAGTCAATCAGTTTGTTCACTTGTTGTTTTTTTG
+ACTGAATGGTGACGACTGGCTCGCCTTCTTTTTCAACAATTGCTGGTATTTTCTTTAAAT
+CTGGTTCGCGAACTTGTGTTGCTCGAAATGTCACGAAAGCTACACTACCAATGACTAAAC
+CCACTAGAACAAGAAAAGCGATTTTCCAGGGATTTCGTTTAAGATTGGTTGGTTGTGTCT
+TTTTAATTGATTTACTTGTTTTTGGCTTTTCTTCATTCATTTTATTCACTACCTTCTGAT
+TTGGTTATCCATTCTTTCTCTGTCTTGACCATTTCATCCCGGACAGCTCCGGCCATAATT
+TGGTAGCCAAGATTATTCGGATGGAAGCGATCTTCTTCATATAACAAATTGTTTAAATCC
+TCTTTGCTAGCACTACTTCCTGTAGTTTCTGAGTCACCACCAGTTACGCCAACTTCATCG
+CCACGACCTTTATAGAGTAAATCATTGATAGGAATGAAATAGGCTCGTTTTTGCTCTTGA
+ACCATTTCTTCGGTTGCTTGATTCCAGTTATCAACGATTTCTTGCATTTCTGTAATTTCG
+GAAAAGTTTAAGTAGAAGGGATTGTAAATTCCTAAGACATAAATAGGGGCCTTCTCGTTG
+TACTCTCGGATTTCTTCAAGTAGTCGTCTTACTCGGCGTTGATAGGCTTTTTGTGGACGA
+TTGAACGAGCTGACTTTCAAGTCGAAAATATTACTACTAATTACTTTCATTAAGTCATTT
+CCGCCAACCGTTAGCGTAATCACGTCCGCAGAGGCAAGGCCTTTTTGAATTTCAGGTTTT
+TCTTTGATTCGTTTTAAAATTTGATCACTACGATCCCCATTTTTCCCAAAATTGTCTGTT
+TGAACACCGTTCAAGTTGTAGTGTTCTTTTAAATCATCTGCCACAATAGGAACAAAACCT
+CCACTATTCGTCAAATCGCCAATTCCTTCAGTTAAAGAATCACCGATTGCTGTATAATGA
+ATGACTTCTTTTTGATTTTTTTGAGCAGTTGTGGCCACTTTCTCTTGCTTTAATAGTGGC
+TTTGCTTTGGGGATGGCCACACTTAACAATGTAAAAACACCTAGCGCAATGAGGATAGGT
+GTTAAGACGGTCAGCAAAATATGCTGTGTTTGTTTTTTCATCTTCGTCACTTCCTTTTAA
+ATAAACCAACAAGAAATTTTCCTTTTCTTGTTAGAAAGAGGTTGCGTCTACTCATTTAAG
+AGTGAGACCCAACCTCGTTATTTCTTAGTCTGTATAGTACATAATAGCAAAGGCATTTTT
+TCCTGTATGTGTTGCAATGACTGGATTCGTATGTAATACGGGAATATCCATGTCTTTAAA
+GATTGCTTGTAATCCTTCTTTGAATCCATTTGCTAGTTCTAGCCCATCCGCATGAGAAAT
+GCCAATTTGTCGAACATTTGGAATCTTACTTAATTCTGATTTCAATTCGTCAAACCATTT
+ATTAAACGTTTTAACGCCGCGGCCTTTCGCTACAGGAATCAATTCCGTATTTTCAAAGTC
+CATGACAACTTTCATATTAAAAATGTTTGATAATAATCCTGTTGTACGGCTGATTCGTCC
+ACCTTTAACCAAATTATCCAATGTTGAAATGCCGATGTATAATTTGGTATTTTGTTTGAC
+GCGTTCAATTTCAGCTAAAATTTCTGGAACACCCGCTCCCGCTTGTGCCAATTTTGCTGC
+TTGAATGACTTGGAAAGACAAACCTTGGTCTGTAAAATCGCTATCAATCACCGTTACTTT
+ACTTGATGATAAATTGCTAGCTTGACGGGCCGCTTCAACCGTTCCACTTAAGCCTTTTGT
+CATGTGAATCGAAATTACTTCACTGCCATCTTCACCTAAGCGATCATATAATTCTACAAA
+TTCACCAATTGGTGGTTGACTCGTTTTGGGTAAGGCCTTCGCATTAGCCATCATGTCCAT
+AAATTTTTCGCCTGGCAAATGATCATCATCTGGATAAACAACGCCATCAACCATAATTGA
+TAAAGGCATCATATGGATATTTAATTCATCTCTAAGACTTTTTTCCATCGTACATGAAGA
+ATCCGTTACGATTTTAACGTTTGTCATAAATTTATCACTCTTTCTTTAAAAGGAACCTGT
+TTTCATGGTAGAATACCATTAAACGGTTAATTATCTAGTTATAGTATAACAGACACTGCC
+GAATTTTTCATCAAATTAAAATAAAGGAAGTGAATTTATTGGAAAAAACGCATTTCTCAA
+AAAAATACCTAATCGTGAACGAAGTCTTGAATGCAGTTACACATGGCATAGGCGCAGGTT
+TAAGTATTGCTGGCTTAGTCATTTTACTTGTTAAAGGAGCTCGTTTAGGCTCACCGATTC
+ACGTGGTATCTTATGCTATTTATGGCTCCATGTTGATTCTACTTTTTTTATCTTCAACGT
+TATTTCATAGTTTAATTTTTACAAGAGCCAAAAAGGTCTTTCAGGTCTTCGATCATAGTT
+CTATTTTCTTATTGATTGCTGGCAGCTATACGCCGTTTTGCTTAATTAGTATTGGCGGTT
+GGTTAGGTTGGACCTTATTTAGTTTAGTCTGGTTAATCGCCATCGTCGGTATTGTCTATA
+AATCCCTCACGTTGCATAAACAAGAAACAGTGAAAAACATTTCAACGATTATTTATATTG
+TTTTAGGTTGGCTCTGTATCATCGCTGCTCGTCCGTTATATGAATCTCTTGGGTTTACAG
+GAACAGCGTTATTGGTCGCAGGGGGTGTGTCTTACACATTAGGTGCAGCCTTCTATTCAT
+TGAAAAATGTGCGGTTTATGCATGTGGTTTGGCATTTGTTCGTCATGCTTGCAGCGATCC
+TCATGTATTTTTCTGTTCTCTTTTATACGTAATCACAGCACAATAAGAACACGATGCTCA
+AAGCATCGTGTTCTTTTATTGCCCTAAATCTCTTTATTATAAAGGATTATTCTTCTTTTC
+GAATTATTTTAACATAAATTAGTAGAAAAGACTTTACAAAACGAACATACATTCGTATAA
+TAACAATACGAACACTCGTTCGAATCAAATGAAGAGGTGATACACATGGAAGCAATTCGT
+CGTGTTGGATTTTTATTTTTTGTATTGGTTATAGGTATTTTTTTGGGAACATTAGGATTA
+CGTCTTGCTTTTATGATCGTGACGCCGTTATTTATTCTTTGGTTTATGTCATGGGATGAG
+AAGCGTTATACACGTACACGTAAACAACAGCAAGCAAGATACGTTTATCGTAAGTTCCCT
+TAATAAATAATAAAACGGTGTGTTCCCCCCAAGCTACGCTCCGTTTTTATAAATATGTCA
+AAGAAAGAGCGAAGGATTAAATCCTTCGCTCTTTCTAATTAAATTAGATTAGTATTCCAT
+TAAGGTAACAATATCGTAGCCATCAATTTTATCGCGGCCATGTAAATCCATTAATTCAAT
+TAGGAACGCACAACCAACCACAATACCACCTAATTGTTCGACTAATTCGATGGTTGCTTT
+AATTGTACCACCAGTTGCTAACAAGTCATCACAAATCAAAACACGTTGGCCTGGTGTGAT
+GGCATCTTTGTGCAACGTTAATGTATCTGAACCATATTCTAAGTCATAAGTCACTTCGAT
+GGTTTCACGAGGAAGTTTTCCTTTTTTACGAACCGGAGCAAAGCCAACCCCTAGTTCATA
+AGCCACTGGACAGCCGACAATAAAGCCACGAGCTTCCGGTCCTACAACCATATCAATTCT
+TTTTTCTTTCGCGTAATCCACGATTTGTTTCGTTGCTTCACGATAGGCATCCCCATTAGC
+CATTAATGGAGAAATGTCACGGAACACGATCCCTTTCTCAGGATAATCTGGAATGCTTGC
+AATGTAATCTCTTAAATCCATTTTTATTTGTCCTCCTCATTCCACAGCCATTGTTGTATT
+GTTTGACAATCACTGTAAAGTAGAAATTCTTCTGTTTTTATTTTTTTCAATCGTTGTTGG
+TACACTTGACTTTCAGTCAATGGTCGATTGTCGGGTTTCTCAATACTGTTTAAAACACCG
+CTTTCTATTGTAACAAATCCTAAGTCAAAAAACACCTGTATCATGAAAATTAATAATTTT
+TCTTGGATATTTAAGTAATTTGCCACCTTCGATAGCTGGGAACGTAGATTTACTTCTTTT
+TGCTGCAAAATAAATTTATACAATGTTGCAAATTGTTCACGTGAAGCCATACCGTTTAAA
+TAAGCTTCTTCTGGTGAAATAAACATCATGTATATACGTTGTATCTCAGTCGCTTCAACA
+ATTTCTTTAACCGTGATTGCTTCCACAGGACAGTCGACAAAAACCAGTTGTTCGATTTGA
+TTTTGAGAGACAGCTTCCACCAATTCTTCTTGGTTTGCCCAAACAATAATATTAGCGGTT
+GGATCTGAAATGAATTTTTGATTTTTTTCATCAAACAAAAGATAAGCTGTTGCTTCTGAA
+GGAATTGGTTTCGTTTGATTATTTTTGCCACGAAAATCAAATAATTGTCTTCCCAATACA
+GCAAAATCAGTCACCATTAATTGTGGTTTCTTACGACCATTCCATTCATTGATGGAAAGT
+TGGCCTGCCACATCGGCGGTTCCTTGTGCTAGTTCATCCGCTTGAGGCCCCATTTGAAAA
+GCAATTGCATCCAATTGTGCCCCTTCTTGATTCATTTGAAATTTCAGATGTGCATTATCT
+GCACCAATTTGCCGAATTTGCGTAGGCGTGATTTCCTTAAATACAAAAGTTGGAACAGTA
+TTATCGGTCCCAAAAGGCGCCAAAATACGCAATTGATCAATAAAAGTAGTCGTGGCCTGC
+GAAACCGCTAAGCTCTCACTAATGAGCAACTCTTGTCCATTAGCCATATCAATTTGATTT
+TTTTCAATAAAGTGTGCCAAATGTTCTTGAACAAAAGGAATATTTTCAACAGGTAAAGTC
+ATTCCCGCTGCCATATGATGCCCACCAAAATGAGTGAATTGCTCACGCACTTCGTTCAAC
+GCCTCATAGAGATTCAATGCGCTAATGCTACGTCCAGAGCCTTTAGCGGTCGTACCAGAT
+TCATCTATTGCTAAAATAATGGTTGGTTTCCCCGTTTCTTGCATAATGCGGCCCGCGACA
+ATCCCTAAGACGCCTTCATGCCAGCCTTGTTTCGCTAAAATATGGACCGGCGCATTCGGG
+TCGATTAAATCCAGGGCTTCTTTGGCAATCGTCGTTACAATGTCTTTTCGTTCATTGTTT
+TGTTGATCAATATATTTAGCGATTTCCAGCGCTTGCTCTTCATCAAATGTAGTCATTAAT
+TCAACACCTGGTGCGGCTTCCCCTAATCGACCTAACGCATTTAAACGAGGTCCGATGGTA
+AAGCCAATTGATTCTTCTGAAACAGCTTCCTTTTTCACACCCGCTTCTTGTAGTAAAACG
+TCTAAACCAATTCGATCACCAGTTTGAATCATTTGAAGGCCCATTTTGACAAACGTTCTA
+TTTTCATCGGTTAATGAAACCAAGTCAGCAATTGTCCCAATTGCTACCAAATCTAATAAC
+TCAATTGGCAATTCACCAAGTAACGCAGTAGCGACTTTGAAAGCCACGCCAACACCAGCT
+AAATCTCCAAAAGGATAGTCTCCTTGCGGATGTCTAGGGTGGACAATCGCATAGGCTTCT
+GGTAATTGTTCAGGCAATTCATGATGGTCAGTAACGATTACATCTACCCCTTGAGCCATA
+GCGTAGTTAATTGCTTCATGTCCAGCTACACCATTATCAACGGTTACAATTAATTGGACT
+CCTTGTTCAATTTGTTCAGCAAATACGTCTTTATTAGGCCCATATCCATGAACAAAACGA
+TTCGGTAGAAAGTACTGAACCATGCCACCGACTAATTCGATTGCTTCTTTCATAACCGTG
+GTACTAGTGATGCCATCTGCATCATAATCCCCATAGACAAGGATTTGTTCACCCGCTTCG
+ACGGCTTGCTGGATGCGGGCTACCGCTTTCTCCATATCATGCATTAAGAACGGATCATAA
+ATATCTTCGATAGTCGGATGTAGAAACTTACGTAATGCTTCTTCTGTCCGGATATTGCGG
+TGCCATAAAAGTTGGCCAATTAATGGATTAATTTGTTCTTTTTTTAATTGTTCTATAAAT
+TCTACAGGTAATTCTGTCTTTGTCTGTAACTGCCATTGATAGTTTGATTTTTTCACGACG
+TCACTCCTAACCAAGTAATTATAGCAAAATTTTTCCAAAAACTAAAGAAAGCATTTTTTT
+AAATCTGAGAAAAAAACTGTGATATCTGTTAGATAAATAGCAGATATCACAGTTTTATTT
+TAAAAGAAACTTAGTGATAAAGTCTCTTCCTTATTTTTGTTCCTCTTCATTCACACGAGG
+TTTCACATAACGATCAATACGACTACCTGACACAGGCGTTGCGTCTACTTCTGTGTTTGA
+TGTTTGTTCGTTGACCACTGGTTCTGCGACTTGTGGTGCTGCCGCTTGTTTGGCTTGCAA
+ATCAGCCAATTGATTATCAAAAGAACGTTGAACTTTTTCCGTTTCTTCTTTGACTAATTT
+ATCCATATCATTTTTATAAATATCCAACTCTTTTTGTACAGCTTTTAATTCCTTACGTTG
+GTTCCAAATAGTGGTTGTGGAGGTTAGTAACCCAACTAGTGCGCCAATAATTGCAGAACC
+TAAAATAATTAAGATTAACGGTCCACTAATTTTAGTAAAACCAAAGTTTACTGGAACAGC
+TTGATTATTTAAAACAGCAAAAATAACAACAATTAAGACCAACACAAGGCCCAAAATAAC
+ACGCCATTGATTTTTCATGACTTGATCGACTCCTTTATTTTTTATTTAAAATATTTCCCG
+CTATGAAATCTCCTAAATGTGGAAACAATGTATAAAAGCGGGCAGCCGCTTCCATGACAA
+ATGGACGATTAATCTCACGTCGAGAAGTCCCCATACTCCCAACCACTTCTTTCGCTAATT
+TCGTAGGGTCCAAAACAATTTTATCCACCGCAGCTAGATATGTGCCTGTCGGGTCCGCTT
+TATCAAAGAATTCTGTTTGGATTGGTCCTGGATTGACAGTCGTTACTGCTACACCCAACG
+GTTTCAATTCTAAACGTAAAGCATTTGAAAAACCTAACACAGCAAATTTCGTTGCAGAAT
+AAACGGTTGATTTAGCTGTAGCCATCTTCCCAGCCATTGAAGCAACGTTGATAATATGTC
+CTTGCCCAGCTTCAATCATTTTAATAGCTACTTTTTGAGTAAACGTCATCATTCCTAGAA
+CGTTGACATCAAACATTTGGCGTGCAACAGCCAAGTCAATTTCAACAAAATTTTCAAACA
+AGCCAAAACCAGCATTGTTGACTAAAACATCTATAGGACCAACTTCTGCTGAAATAGCTT
+CAACCACACGTTCAACACTTTCTGGATCGGCAATATCTAATTGATAAGAAAATGCTTCTC
+GTCCGCTTAAAACAGCACACTGCTCGCGAACTTTACCAATCAAATTAATTCTGCGGGCGC
+AGACAACGACGACCGCCCCTTGTTTAGCTGCTTCATAACAAATTTGTTCACCTAAACCAG
+CTGAACCTCCAGTTACGACAACGACTTTATTTGTTAAATCCATCTAAGCTCCTCCTTCAT
+TGGCAAATGGAATCTCAATGATATCCATATCTTTTACGATTTTTGTATTGGGGAAAATTT
+CTTGGGCTTCTTCTTGAAGCTGATAGGCCTCTTTGGTTAAATAACGGGCACTAATATGCG
+TTAAGATAAGTTGTTTTACTTGCGCTTCTTTTGCAACTTCAGCTGCTTGTTGACTGGTTG
+AGTGGAAGTAGGCTTTTGCCATTTTTGCTTCGTGTTTATTAAACGTACTTTCATGGACTA
+AAACATCCGCTCGTCGTGCTAAGGTTACGCTATTTTTGGTTTTGCGAGTGTCTCCTAAAA
+TCGTCACGATTCGTCCAGGTTTACGCTCTCCCACAAACGCTTGTCCATTAATTTCCTGTC
+CATCAAAAACAATCGTTTCACCACGTTTGAGTTTGCCATACAACGGCCCAGAAGGAATCC
+CTAAAGCTTGAAGTTTCTCTACTTGTAATTCTCCTTCATGCGCTGCTTCCTCAATTCGAT
+AGCCAAAGCTCGTGATGCCATGGTCCAAGATATTACAGCGAACAGTGAATTGTTTATCTT
+TAAAAATAACGTCATTTTCTTTCGTTAATTCAATAAATTTCAGTGGATAGGACAACCGCG
+ATTGCGAGACCCGTAAAGAAGTCTTGACAAAGTCAGCAATCCCAACTGGTCCATAGATTT
+CTAAAGGTTCTGTCCCGCCCTGAAAAGAACGACTACTTAACAAACCAGGTAAACCAAAAA
+TATGATCCCCATGTAAATGTGTAATAAAAATCTTTTCAATTTTTCTTGGGCGAATACTAC
+TTTTTAAAATTTGCAATTGAGTCCCTTCACCACAATCGAAGAGCCAAACTGCATTTCGTT
+CATCTAATAATTTCAACGCAATCCCTGTTACATTGCGATGTTTTGCTGGTACACCAGCGC
+CTGTTCCTAAAAATTGTATTTCCATCTGCTACCATACTTTCTTTTAAACTTCCTTTTTAT
+TTTAGAAGAAGTTTGCTCCTTTAGCAAATAATAATTTATCTATTTTCTCAAAGTTTTCTT
+CTTAGTTTACCGCATTTTACGATAAAATAACAAAAAATTAACAAACTACCATAAAAAACC
+GTGATTTCTTAGTATTTTAAAAGACTGTTTCCCTTTATTCAGAAAACAGTCTTTGCTCCT
+TATTCTTCTTTCGATGTCGCTTCTTTGTGTTGTTCTTTTTTTGCTTGCCACGATTGTTTC
+GCTTCATTTGCAACTTCGTTCGCATCGTTAATTTCTTGTTGGACTTCCTCTAAATCAAGC
+CGCGTGATTTCGCCACCTAAGTCAAACATAACCAATTGGTTGAGCGGACGATTGTCTTCT
+TCTTCTGCAATTAATAATAATCCCGTTTGTCCTTCATCAATCTTTTGAATCACATGTTCA
+AAAACCGTTTGTGCTTCTTGAATTTCTTTGGCATCTTTGCTTGCACCATACATACTTCCA
+GCAAACCAGCCAAAAAGAATGCCCAGAGGACCACCTAATATGCCTACTAGCATCCCAATC
+ATGCTATCTTTTGATGTATGATTGTTGCCTGTAAAATCGATAAAATCATTGATTTTAAAT
+TGATGCTGGCCATCATTAACATGCGTAACAACCGCCATTTGCTCACCTTTAAGCTGTCTT
+TCTGCCTGCATCTTTTTTATTTCGGAAAATGCTTGGTACGATTTACTTTCAATATCAAAG
+TTCATAATGATAATTCGTTTTGTCATACAAATCGCTCCTTTATTCTGGATACATCTATTT
+TAGCAAGAAAGGCTTGTCTCTAGCAATGAAAACTTTTTGGTTATGTATAAAAAAAGAAGA
+TAGCTAGGCTACCTCCTTGTTAATGCTTATTTACCATCAAGAATATTTAAACGGACCTTT
+TTCGGACCATCGATACGTACACTATAAACAATTGTCCGAATTGCTTTTGCAACACGCCCT
+TGTTTACCAATGATACGTCCAATATCTTCTTTGGCCACAGTCAAATTATACTCGAGGAAA
+TCAGTTGATTCCTCAATTTCTAATGAGACTGCTTCAGGTTGACTGACTAACGGACGGACA
+ATAGTTAAAATTAACTCTTTCACATCTGCCATATTCAATCACCTTATTTCTTAACGTTTT
+TAGCTTCATGATGTTTTTTCATAACGCCTTCTTTTGAAAGGATGTTACGAACTGTATCAG
+AAGGTTGCGCACCTTTAGATAACCAATCTAAAACTAAATCTTCTTTTAAAACTACTTCTG
+CAGGGTCTTTCAAAGGGTTGTAAGTACCTACAGTTTCGATGAAACGTCCATCACGAGGAG
+AACGAGAATCAGCTACTACAATACGGTAAAAAGGACTCTTTTTAGAACCCATACGTTTTA
+AACGAATTTTAACTGCCATTATTAAATACACCTCCATTAACTTAATCACAAGAGTTAGTT
+TAACAGATTAACAACAACCTGTAAAGAGTTTTTTCTTGACACCTTTACTTTTTTTCAATT
+TTTTTAGCCAATTTGCAGGAAAACAAACGAAATAATGAAGAATTTTTACAAAATTTGATA
+ATAGTTGTACTGGTTTCTCACTTGAAAGCCTTCTGTTTGATAGAGATGAAGCGCTGCTTG
+ATTTTCTGTTTCAACTTCTAAAAAAATAGTCGCTGAAGCTGAATTTTCTAAAATCATTCG
+GAGCGCAGACTGTAACACTTGACGGCCAAGACCGCGACCTCGTTGCGTTTTTGTCACAAC
+AAAGCCATAAATCCCCCATTCGTTTTCAAAATGATCCAAACGTAGCGTGGCTAAAAGTTG
+ATTGTTTTCTTTATAAATAAGTGTTCGTTGAAGGTCCTCCGGCAAAGGCGTACCTTCTAG
+TAACCTAGCCAAGGAATGCAAATCAGCCACTTGTGGTCGGAGAAGTGTCAGCTTCGCCAA
+TTCCTGTGAGTAAGTTTCTCTTTGAAAAACCAGATACTGTTCTGAAAAAGCTGGCACAAT
+TCCTTGTCTATTAAAATAATTCAGGCCAACAGATTGCTTGTCGTCCATCACGAGAAAGAC
+TTCTTTCATTCCCCACAAAGCTGCTTGCTTTTCGAGTTCTTGAACAAGTTCTTCAAAAAA
+TGGCCCTACATTTGGCGCAACAATCGTCGCTTCCAAGGTTTCCCCATCAAAACAATACCC
+TACGATATACGCTTGTATGGTTTGTTCCTTCCTGTATAAACCATAATAAGTATAAGCTGA
+TTCCTCAGGAAATGTTTGTTCCAATTTATAAAAAGTTCCTTGTTTAATCATTTCCTTGTT
+TTTTAATTCAGTCAATGTTTGTTTCTCCAACTGTGTTAACTGTCGGCGCCAATTTATTTT
+TTTATTCAAGCAGTTGCTCCTTTACTCATCCTTTTACTAGCTATTATACGTGAAGTTACG
+AAGTTCAACAATGTACAAGGATAAAACGTTTGCGCTTTTTTTGAAAAAGTACTATCATAA
+AGTAAGTAAAAGAAAAATGGAGGGATTTACATGACAAAAAAAATTGGTATTTTTGTAGGG
+AGTTTAAGAAAAGATTCATTTAACAAATTGGTAGCAAAAACAATGGCGGACTTATTTCCA
+GCTGATTTCGAACCTGTTTTTATTAACATTGGTGATTTAGAATTATACAATCAAGATTTG
+GATGATGAAGGAACCCCCACCGAAGCTTGGACAACATTCCGTGAAGAAGTCAAACAAGTA
+GATGGTGTGATGTTTGTAACACCAGAATATAACCGTTCAGTACCAGCTGTTTTAAAAAAT
+GCATTGGATGTCGGTTCACGTCCGTATGGCGAAAGCGTTTGGGATAAAAAACCAGGACTT
+GTGGTGAGTGTTTCACCAGGTGCAATTAGCGGATTTGGTGCGAACCATCATTTAAGACAA
+TCATTAGTCTTCTTAAATGTTCCAACTTTACAACAACCTGAAGCCTATATTGGCGGTATT
+ACGAACTTAATTGGTGAAGATGGTAAAATTATTGATGGCACTGTTGGCTTCTTACAATCA
+ATTGTAGATGCTTACGTGGATTTCTTTAATCGCTTAACTGCCTAATTGAATCAATCGAGA
+AAAAGTGAGGCAACTTTTTAAAGGTTGTCTCACTTTTTTTATTTTTTTGCTTGACCCTCT
+CGTTACGTAAAGGTTTATGATAGATTTTGTCAGGAGGAATGAATGATGGAATATACAATT
+AAAAAAATGGCTTCACTATCTGGCGTCAGTGCACGGACGTTACGATATTATGATGAAATT
+GGTCTTCTTCAACCAGCCAGAATTAATTCTTCTGGTTATCGAATTTACGGGCAAGCCGAG
+GTGAATCGTTTGCAACAAATTCTTTTTTACCGTGAATTGGATCTGAAACTAGATGAAATT
+AAAGAAATTTTGGAGCAACCTGACTTTAATGTTGAACAGGCTTTATACGAGCATCAACAA
+AAACTATTGGAAAAGCGCAATGAAATTGATCGTCTTTTAGCCTCTGTTCAACAAACCTTA
+CACCATTACAAAGGAGAGATAAACATGTCAGATCAGCAAAAATTCGAAGCATTCAAACAA
+CAAAAAGTTCAAGAAAACGAAGAAAAATATGGTAAAGAGATTCGGGAAAAATATGGCAAC
+GAAACGATTGAACAAGCCAACAAAAAATATTTAAACTTGACGGAAAAAGACATGCAAGCA
+ATGCAAAACGTGGAAAAAGATTTATTTTCTAAGTTAGCCATGTATCAAAAATCACCCAAG
+TTGACTAGCCAACTTGCGCAAGAAATTTTCCAATTACACAAAGATTGGTTAATGTACTCT
+TGGTCAAGCTATTCGCCAGAAGCACATAAAGGGTTAGGGCTTATGTATGTTGGTGATGAA
+CGATTTACGTCATATTATGAACAACACGGCGCTGGTTTTGCCGAATCGTTAAACGCAATT
+ATCCAAAACTACGCTTAAACAGAAAGTGCGCCATCAGTCGAAGAGACTGATGGCGCACTT
+TCTGTTTCTTACGATAATTAACTAAAGCCTGTTTATCTTTTTTTCTTTTTCTTCTTTTTG
+TTTTTCTTCATCATACGATTCATAGCCATTTTACCTAGCTTGCCTTTAACGCCGCCACCT
+AACATTTGATCCATACCAGGAATGTTCATATCCCCTTTGGACATTTGTTGCATCATTTTT
+TTGGATTCTTTAAATTGTTTAATCATACGATTGACTTCAACCACACTATTTCCTGAACCA
+GCTGCAATTCTGCGGCGGCGACTAGGATTTAATAGATCAGGATTTTCACGTTCTGCAGGG
+GTCATTGATAAGACCATCGCCCGTTTCCGTGCCACATCTTTTGGATCGACTTTGACATTT
+TCAATACCAGGCATGTTACTCATTCCAGGGATCATTTTTAATAAGTCCTCAATCGGTCCC
+ATGCCCATAACTTGATCCAATTGCTCAATAAAATCGTTAAAGTCAAAACTGTTTTCTTTC
+ATTTTTTGAGCAAGTTCTTCTGCTTTTTTCTCATCGTAATCTTGTTGCGCTTTTTCAATT
+AGCGTCAACATGTCCCCCATACCTAGGATACGACTCGACATACGATCGGGATGGAAAATT
+TCTAAATCGGTTAATTTTTCACCAGAACCGACAAATTTAATCGGAGCGCCCGTTACTGCC
+CGAATTGACAGCGCAGCCCCCCCACGAGTATCGCCGTCCATTTTGGTAATAACAACCCCA
+GTAATTCCAAGCTGTTCATTAAAACTATCTGCAACGTTGACAGCATCTTGCCCCGTCATC
+GCATCAACAACTAACAGAATTTCATTGGGATTAGCCAACTCTTTAATTTGTTTCAATTCG
+TCCATTAAAGCTTCGTCAATGTGTAAACGGCCGGCCGTATCAATTAAGACATAATCATTT
+TTCTTTTCTTTTGCTAATGCTAACCCTTGACGAACAATTTCCACTGGATTAGCATCTGTT
+CCCATATCAAAAACGGGAACTTCTAATTGTTGACCTAAAACCTTCAACTGATCAATCGCT
+GCTGGACGATAAACGTCACCAGCGATTAAAAGCGGACGAGCGTTTTCAGTTTTCATTAAG
+TGTTTTGCTAATTTACCAGTAAAAGTTGTTTTACCAGCCCCTTGTAACCCTGTCATCATA
+ATCACTGTCGGGATTTTTGGAGATTTATTCAGTTCAACCGTTTCTGAACCTAACGTTTTC
+GTTAATTCTTCATCAACAATTTTTACAATTTGTTGGGCTGGTGATAAGCTTTCTAATACT
+TCGACTCCTACTGCCCGTTCTCTGACGCGTTTTGTGAAATCTTTGACCACTTGTAAATTA
+ACGTCGGCTTCTAATAAAGCCAAACGGATTTCTCGCATCATTTCTTTTACGTCGGCTTCG
+GAAACTTTTCCCTTACGACGGATTTTACTCATTGCCTGTTGTAGGCGGTTTGTTAAACTC
+TCAAAAGCCATAGTTTCATTCCTCTATTTCTTGAATTTGTTCAATATATTTTTTGATTTC
+ACTATCTTTGGGATAAGTTTCTTGAACATACTGCTGTAGTTGTTCAAGATATTCTTTCCG
+TACAACATAGTTTGAATAAAGATGTAACTTTTTTTCGTATTCTTCTAAAATTTTTTCGGT
+TCGTTTAATGTTATCATAAACCGCTTGGCGACTAACCTCATATTCTTCCGCAATTTCTCC
+TAAAGAAAAGTCATCAGCATAGTAAAGCTCCATATAATTCATCTGCTTTTCCGTTAATAA
+TGTCGAATAAAATTCAAATAACGCATTCATGCGGTTTGTTTTTTCCATTTCCATGAGCCG
+TGCTCCCATCTTCAATCCCTTATAGGTTACCGATTTCATAGGGAATAGTCAATCTTTTTT
+TACTAAGTTTTTACCTTTTAAAAAGAAATGTCCGCAAGTTGCCATGTTTCTTCAGAATAA
+ACGGTCATTCCTTGTTGAATAAAATAAGCAGTTGCGACTCCAACTCCAGCTTTTTTAATG
+CCAGAAAATTGTCCATCATAAATCAGCTGGCTGCCACAGCTGGGACTTTTTTCTTTCAAA
+ATCAAGGTTGTAATTTGTTGAGTTTTTAATTTTTGATACGCGCGTTGTGCCCCTGCTTTA
+AATGCCTCAGTCACATCTTCCCCGTTATCCGTATATACATAAGCAGTATTCGCCCAAACA
+TCAAAGCCATCCCCGCCAATGATTTCTGCTGGCGGACGTGGAATAGGCAACTCTCCTAAA
+ACTTCGGGACAAATCATTATTGCTTTTCCATTAGTTACAAGTTGTTTTAACGCTTCTTGT
+TCTTGAGATTTTCCATCGTAACGGCAACAAATCCCACCTAAGCAACTACTAATACCAATC
+ATTCGCTTCTCCTCATTTCATTTCTCTATTATACCATGAGTTGACTTTTCTCAAAAGTAG
+CATTCTCGCTTACTTTAAAGTACGTTCTTCCTCTAAAAATATGTTAAACTAACAATAGTG
+AAATATACACTTATTTTCAGAAATTTCTTGAAGGAGTTATGTAAATGAAAAAAGTTCTTG
+TCGTCGATGATGAACCATCGATTTTAACTTTGTTAACCTTTAATTTGGAAAAAGAAGGCT
+ATCAGGTGACTACTTCCGAAGATGGTAAAAACGGCTTCGAATTAGCTTTGTCTAATCAAT
+ATGATTTTATAATTTTAGATGTAATGCTTCCTGGTATGGATGGCTTAGAAATTACCAAAG
+CACTTCGTCGAGAAAAAATTGACACGCCTATTTTGATTTTAACTGCCAAAGATGAACAAG
+TAGATAAAATCATCGGCTTAGAAATTGGGGCAGATGATTATTTAACAAAACCTTTTAGTC
+CCAGAGAAGTCCTAGCACGCATGAAAGCTATTTTTCGTCGTTTAAAACCTACCACGACCG
+AACCGCTTCAAGAGGACACACCTAAAGCTCCGCTTGTGATTGGCGAGATTCGTGTGGATG
+AACAAAATTATGAAGTCTTTGTGCGCAATCAGCCCATTGAACTAACACCGAAAGAATTTG
+AATTACTCGTTTACTTTATGAAACGCAAAGATCGGGTCATTAATCGGGAAACCTTGTTGG
+AACGAATTTGGCAATATGACTTCGCTGGACAAAGTCGCATCGTCGATGTCCACATTAGTC
+ATTTACGTGATAAAATCGAGCCTGATCCCAAACGGCCCGTTTACTTAGTAACTGTCCGTG
+GCTTTGGCTACCGTTTTCAGGAGCCAAAACGATGAAAAAGAGACTGCGGATTGAATATTT
+TTTAGTTGCGGCAGTCATGCTTTTATTATTTGTCGGAAGTATTGCAGCGACCAATTTTTT
+CTTTCAAAAAGAAATGGTTGCTCAGCAAGAAACCTATTTAAGAAGAAAAAATACCCTTTT
+AACAGACCAGTTGCCCCCTTCCGTTTTCGAAAAAGGGCAACTGACAAACCAACAACAACT
+CCTTGTCACCCATGCGTTAGATGATGCAGAAGAACGGGTAACTTTGTTGCAAAAAAATGG
+TACCGTCTTTTTTGACAGCAGCCAAAATGAACCGCTAGAGTCGCACAAAAAACGACCTGA
+AATCGCTGCGGTTCTATCAGGAGCTACCTATGGTTCAGC
+>NODE_4_length_39999_cov_63.2942_ID_7
+AAGGTTTAAGAAGGGGCAATAGAATTATGAAATCAGGAAAGTATGAAGTTAGAGCTAAGG
+GCCATGGCGCAAGTTTCATGCCTATGGAAGTAACCCTCTCTGAAGATGAAATTGAAGATA
+TTAAGGTAGATGCTAAGGGCGAAACTAAGGGTGTGGCAGATGAAGTCTTTAGACGCTTGC
+CAGAAGAAATTGTTAAAAATCAAACTTTAAATGTTGATACCGTTAGTGGTGCCACTATTT
+CTAGTCATGGTGTGATTGATGGAGTAGCCAGTGCAATTAGTAAAGCTGGTGGAGACCCTG
+ATGAGTGGAAAAAACGTGCCAAGCCTGCAGAACAAAGAGAAAAAGACGAAACATATACTA
+CTGACGTTGTAATTGTTGGTGCTGGTGGTGCAGGTCTAGCTGCAGCAGCAAGAAGCATTC
+AACATAATAAAAAGGTTATTGTGCTTGAAAAATTCCCACAAATTGGTGGTAATACCAGTC
+GTGCTGGTGGCCCAATGAATGCGGCTGAACCTGATTGGCAAAAACAATTTAAAGCTTTAG
+CTGGTGAAAAGGAAACTCTTGAAGAACTGGCAGCAACTCCAATTGAAAAAATTGATCCAG
+AATATCGAACAGATTTTAAGGAGTTACAAAAACAAATTAAAGAATATGTTGCTTCTGGAG
+CTAATTACTTATTCGACTCAAAATTACTTCATGAAATTCAAACTTATTTAGGTGGTAAAC
+GTACAGATTTAAAGGGTAATGAAATTCATGGTAATTATACCTTAGTTAAAGAATTAGTTG
+ATAATGCTTTAGATTCAGTTCACTGGTTGGCAGATTTAGGAGTAGTTTTTGATCGCAGCC
+AAGTAACAATGCCAGTTGGTGCCTTGTGGAGAAGAGGACACAAGCCGGTTGAGCCAATGG
+GCTATGCCTTTATTCATGTTTTAGGTGATTGGGTAAAAGAACATGGTGGCACAATTTTAA
+CTGATACTCGTGCTAAGCATTTAATTATTGAAAACGGAAAAGTTTGTGGTGTAATTGCCA
+AAAAGCCTGATGGCAGTAAAATTACTATTCACGCCAAAGCAGTAATTTTAACTGCTGGAG
+GATTTGGCGCAAATACGCCAATGGTTCAAAAATATAATACTTATTGGAAACATATTGATG
+ATAATATTGCGACTACTAATTCTCCAGCTATTACTGGTGACGGGATTGGTCTTGGTAAAG
+AAGCAGGTGCAGATTTAGTTGGAATGGGCTTTATTCAAATGATGCCTGTTTCTGATCCTA
+AGACTGGTGAACTATTTACTGGTCTTCAAACTCCTCCGGAAAACTATATTATGGTCAATC
+AAAAGGGAAAGCGTTTCGTAAATGAGTTTGCGGAACGTGACGTTTTAACTAAGGCAGCGA
+TTGATAATGGTGGTTTATTCTACTTAATCGCTGATGACAAGATCAAAGATACTGCTTATA
+ACACAACGCAAGAATCACTTGATGCTCAAGTTAAAGCAGGTACCTTATTTAGAGCAGATA
+GCTTAGAAGAGTTAGCTGAACAAATCGGTATGGATCCTGATACTTTAGTCGATACAATCA
+AGAAATATAATTCATATGTCGATGCAGGAAAAGATCCTGATTTTGAAAAGTCTGCCTTTA
+ACTTAAAATGCGAGGTGGCACCATTTTATGCTACGCCAAGAAAGCCTGCTATTCATCATA
+CAATGGGTGGTTTAAAGATTGATACTGGTGCACATGTTTTAGATAAAGATGGTAAACAAA
+TTTCTGGTTTATATGCGGCTGGGGAAGTAGCTGGCGGAATACATGCTGGCAACCGTCTAG
+GAGGGAATTCTCTTGCTGATATCTTTACTTTTGGTAGAATTGCCGCAAACAGTGCTATTG
+ATGAATTAGAAAAATAGTATAGATAGATTAAAACGTTGTAAACACTAGTATTTGCAATGT
+TTTTTTGCTAAAATACTAAAAATACCTAATTTTTTGGAGGACTTGAATTGAGAGAAGCGC
+AGGAAAAAAAGTTAACTACAAAGCAATACTTAATTGTAGCATCGATGATTTTTGCACTGT
+TTTTTGGTGCAGGAAACTTAATTTTCCCACTTCATTTAGGCCAGCTTGCTGGTAAAAACT
+GGGGACCAGCAGCAATTGGTTTTTCAATTACAGGAGTAGTCTTACCCTTACTTTCACTTC
+TTGCAGTTGCAATTACTCGCAGTAATGGTGTTTATCAAATCGGATTACCAGTAGGAAAGG
+TCTTTGCTCTTTCTTTTATGACTTTGATGCAGCTAGCAATTGGTCCTTTATTTGCAGCAC
+CAAGAAATGCCACTGTATCTTATACTGTGGGGATTGCACCTCTTTTGCCTAAGCAATTTC
+ATGGAATCGGTTTGATTGTCTTTACAATTATCTTTTTTGCCATAGTTTATGTGATTGCCT
+ATAACGAGAGTGATATTCTTTCTTCTTTAGGTAAAATTCTGAATCCGATCTTTTTAATTT
+TACTTTTTGTTGTTTTTGTAATTGCGTTTGCTCGCCCACTTGGTAATCCTGAGATGGCCG
+CACCTACTAAAGAATATATGAACGGCGCAATAGTTAAGGGCTTTTTAGAGGGCTATAATA
+CTATGGATGCTTTGGCAGGCTTAGCCTTTGGGGTAACTGTGGTAACAGCAATTAAAGAGC
+TAGTTAATAATGACAAAAAGAAAACTGCTAAAATGACTGCTAAGTCGGGGTTAATTGCAG
+TTTTTGCAATTGGTATAATCTATACTTTATTAATCGTTATTGGTGCGATGTCATTAGGGC
+ATTTTAAAATAGCGAGTGACGGCGGTATTTTATTTTCAGAGCTCGTTAAGTATTATGCTG
+GTATTTTTGGACAGGCTTTGTTAGCTGTTTTAATCTTTTTAGCCTGTTTAACTACCGCAG
+TTGGAGTCTTAGCAGCTTTTGCCTTAGATTTCAGTGCCCACTATTCAAAGATTAGCTATA
+AAGGTTGGCTAACAATCGGTTGTTTAGGTTCTTTAGCTACAGCAAATTTAGGTTTAGAAA
+AGATCATTCACTGGTCACTTCCTGTTTTAATGTTTTTGTATCCCTTGGCTATTGTGTTAA
+TTATTTTATCTGTATGTTCACCACTATTTAAAGGTGACATGGTAGTATACAAAATTACGA
+TGCTTTTAACTCTAGTTCCAGCGATTTTCGATCTAATTACCAACTTGCCTGCACCAATTT
+CTGGAACGCAGTTTTATAAAGTAGTAAGTCAGATTCGCTTGCAATATCTACCTTTAGCTA
+ATATTGGCTTATCTTGGGTTGTACCAACAATTTTAGGATTAGTTATCAGTGTCTTGATTC
+ATTTTGGGCGTCGTAAAGCTAATAAAATATAGTAGTTCGGCTATGGTTCATTTGAATCAT
+GGCTTTTTTGTTGGGATAATGAAATTAGGTGATAAAAAATGAGTTTAACCAATAAAGTGC
+TCGAAAAAGATGTGCATGATTTATTTACTCGGGTAGCGCCGCATTATGATCAGATGAATA
+ATTTAATTAGCTTAGGTACACAAAAAAGCTGGCGCAAGAGATTTTTAAAAGAATTAAAAG
+TAGCACCGGGTGATTTTGCCCTAGATTTATGTTGCGGTACAGGCGATATTACGATTGCTT
+TGGCAAAACAAGTTGGTCCGTCAGGAAATGTAATTGGGCTTGATTTTAACCAAGAAATGC
+TTGATTTAGCTGAGCAGAAAATACGTCAGCAAAATTTACAAAAAGAAATTCAGTTAAAGC
+AAGGGGATGCAATGCATTTGCCTTACCCAGATCAGAGTTTTGATATTGTAACGATTGGCT
+TTGGCTTACGGAACGTTCCTGACGCAAATCAGGTCTTGAAAGAAATTTATCGAGTATTAA
+AGCCAACTGGTAAAGTTGGAGTATTAGAAACATCGCAGCCAACTAATCCGCTTATTAAGC
+TAGGGTGGAAGAGCTATTTTAGGCTGTTTCCTAGCTTTGCGAAATTACTAGGAGCCAATG
+TATCTGATTATCAATATTTGTCTCATACAACCGCTGAATTTGTTTCTGCGCAGCATTTAA
+AAGAAATGCTTGTAAAAAATGGATTTAAAAATGTGCAGGTAAATAAATTAAATCTAGGTG
+CGGGTGCAATTCATGTCGGAATTAAGAAGTAAATGAGCTAAAATATAAAATAAAAACTAA
+AAAAAGGAGAATTTTATGAAAACTGGTACTAAAATTATTACTTTAGACAACGGTTATCAC
+TTGTGGACTAATACTCAAGGTGAAGGCGATATTCACTTATTAGCGCTTCATGGCGGACCT
+GGTGGCAATCACGAGTATTGGGAAGATGCTGCAGAGCAACTGAAGAAACAAGGATTGAAT
+GTACAAGTTACAATGTATGATCAGTTAGGTTCATTATATTCAGATCAACCAGATTATTCT
+GATCCAGAAATCGCTAAAAAATATTTAACTTATGAATATTTCTTAGATGAAGTTGATGAA
+GTTCGTGAAAAACTTGGTCTAGATAATTTTTACTTAATTGGCCAAAGCTGGGGCGGTCTT
+TTAGTTCAAGAATACGCTGTTAAATATGGTAAGCACTTAAAGGGTGCAATTATTTCGTCA
+ATGGTTGATGAAATTGATGAATATGTTGATTCAGTTAACAGAAGAAGACAAGAGGTTCTT
+CCACAAACTGAAATTGACTTTATGCACGAATGTGAAAAGAATAATGATTACGATAATCAA
+CGCTATCAAGATGATGTGCAAATTTTAAATATTAATTTTGTGGATAGAAAGCAACCATCA
+AAGCTTTACCATTTAAAAGACTTAGGTGGCAGTGCAGTTTATAATGTCTTCCAAGGTGAT
+AATGAATTTGTTATTACTGGTAAGCTTAAAGACTGGCATTTTAGAGATCAACTTAAGAAT
+ATTAAGGTACCAACATTAATTACTTTTGGTGAAAATGAAACAATGCCAATTTCTACTGCT
+ACAATTATGCAAAAAGAAATTCCAAATTCCCGTCTTGTTACTACGCCTAACGGTGGACAC
+CATCATATGGTTGATAATCCTGACGTTTATTATAAGCACTTAGCTGACTTCATTCGTGAA
+GTTGAAAATGGTAATTTTAAGGGTGAATAAAGATAAAAAGTCCATGCGATAGTTTCTATA
+TTGAAGCTCTAGCATGGACTTTTTAAGCATATAAATCGCTTTCATGACATATATTCTATA
+TAATTAATAACAAATATAGTTTTATTATTTTAAGGAGAAAAGCCATGAAGAGAAAAATAA
+GTAAACTACTTGCAGCGACGGCTTTAATGGGGACACTAGGAATTTCAGTAGTGGCTTGCG
+GCAATAATGATTCAACCAGTAAAACTAAACAGTCAAGTGTAAAGAAGACTGCTAAAGATA
+AGGCAAGTAATACAAAAAATGCAACAAGAAAAAGTCAGATTAAACTTAGTCAAACTGAAG
+CAATAAATAAGTTTGATAAAAAGTATTCTGATAAAAAATTAAAAGAAATAGATCTAAAAT
+TAGATGGTAATAAATATCTTTATGAAATTACAGGATTTGATAAGGATAAAGAATATGAAA
+TGACCATCAATGCCACAAGTGGAAAAGAAGTCAAATCTAGTTCCGAAAAATTAGACTTAG
+ATGAACGTTTGCAAAAGGGACTTGATTTAGATAAAGTGATATCTCGTGATCAAGCAAGTG
+AAATAGCAGAAAAAGAAGTTAAAAATAGTACTGCTAAAGAATGGACTCTAAAAATGGATC
+AAGATAAAGCCATTTGGGATGTAACTGTTGAATCAGGTTCAAGCAAACATGAAGTAGAAA
+TTGATGCTATTTCTAAGAAAGTTATTAAATCAGAAAAAGATGATTAAACAAAAAAATTCA
+GAGTTTTTAAGCTCTGAATTTTTTTATTAGTATTTTTATAGAAATTAATTTAATAGGTGA
+TTAGCTTGTCAGCGTTCATCGTTTCATCGTCTAACTTATAAGTCTTTAATTCAAAATCAT
+TTTCAAAGTTGCAGTAATAAGTCTTAGTAGCAGCAGAGTAGCAAGCGGTGTAGACAGTGT
+ATTCATCGCTACCCAGTTTGTTAACTACGCTACCCTTAATCATCGCAACAGACTTTAAGA
+TGTTAAAGAACTTAGCCACGTTAGCTTTTTCACCCTTAACAGTTGGGTAATTAACATTTA
+AGTAAGCTGCTTTAACAAAGCGATCTGCTGGAATGCTATCACCTGGTAAACCTAAGCTGC
+CAGTGCCAACGCCCCATGGAGCAACTTTTTGACCGTTCCAGCTTTGAGCTGTAGCATCAT
+GTGGATCTAAACCAGTATAGTTGCCAAGGTTAGTAAGATGCCAGTTAAAGTCTGGACTGT
+TAGTTAAAACGCCAAGCTTATCATCGAAGACTTTCATTCCGTATTGTTTTGAAACTTCAA
+CAATAATAGCTTCATCTTTGTCACTAATAATCCAGTGAAGAGGAGCAACTGCAAATGATG
+AGTTAAGAGCTTCATTAACTAAGTTAACGTTCTTTAAAGCTTCTTTTACATCGCTAACTT
+TAGTAAAGTTCTGGGTGACCCAGAGCATAATTTCGTAAGAAGCTAAATTGATTTTTCCAT
+CAATTGGACCATCGCTAAATTTAGCAAAATGTGGGAAGTTTAGACCAGCAATTCCCAAAC
+CATCTTCATTGAAACAATCAAAGTAAGAAGGATAGCCATCAACTACAATTCCCATACCGA
+TAACGGCTTTTTTAGTAGTCGTATTATCTAAAAACTTATATGGAAGAGGATAGTTGCGTG
+GTGTGATAATTACACCTTCACCATAATCTTGTCCAACATCTAAGTTACGTCCAAAGTAGA
+GATTTCCTTGATCATCTGTAAATCTTAAACCAGTACACATTTTAAAATCCTCCTTAACTA
+TTTAGCAGTAGTTTTAGCTTCTTGCTGAATGATGTATTTCTTTTGACTTCTCTTAATTTG
+AATAACGGCAAATACTAAGATGATGAAACCAATTGCTACAAAGGCAATCATGAAGTACCA
+AGCAACTGTAAAGCTGGCTTTTCCTTTAATAATTCCGAATAATGGAGCACCAATAGCATA
+TCCAATTGCATAAGCTAAACCCACATATCCTAGCATTACACCTTGATCTCTTGAACCAAA
+GAGATCCTTGGCCATAAATGCAGGACCAGACATGTAGCTAAATACAGCTAAACCACAGAA
+AATAGCATAAGCAACACCTGCGATTTTACTTACGTGAGCACCATAAGGTTGAAAACTGAT
+CAAAACCATCATTAAGATGGATAAAACATACATGCAGCCGGCATAAGTCATTGATTTGGC
+AGTACCAAATTTATCAAATAAGAAGCCACCGGAAACATTTCCAATTAAACAACCAACACC
+GTACATTGATCCAATGAGGCCAACATCTGTTAGTGAAAGCTTAGTATCAAGAAAGGCCGC
+ATAATCTTCATTTAAGGAAGCTAGGCCTAAGCCAATAATTAGAAAACCAAGACTGAAAAT
+CCAGAACCATTTCATTTGTAGAACTTGTTTACTAGTCCAGCCCTTAAATTCTTTCGCCTT
+GGCCAATTCTGCTTCTTTTTTGCTTTCAGCTAATTCAGCATCAGAAACGACGATTTCATC
+TTTCTTAGGAGTTCTAATAAAGCAAGCAATAACTATACCAATTACTAATAGAGCAACTGC
+GAAGATGAAAAATGGTGCCATTGAGGTCAAGTGACCTGTCTTAGTGTTACCAGTCATAAA
+GTGCTTTAAAATAGCTTGCGTTGCAGGTTGTAAGAAAATATTACCAATCGAACCACCGCA
+GAAAGCAATTCCTAAAGCAGCTCCACGTCCTTTTGCAGGGAACCAGTGGTTAATAACCCA
+AGGAACACCTTGGCCGGAATAAAAAGTTGAACCGATCATACAAATGATAGCAGCAATATA
+GAATCCTGGCAGTTTTGTGCTAATTCCAAAGATTATATAGGCAATAGCAGAAAGGCCAAT
+ACCGATTAAATACATAAGTCTGAAATTAACTTTCTCTAATGCTTTACCAATAAATGGCGA
+AGCAACTGAAGCAAAAACTGCCCCAAACGTAAAGATTAATGTATACGATGCTAAGGTAAA
+GTGAAAAGTATTAACTAACGGGTGGATAAACAAAGGTTGAATATTTTGAGCAATCCCATA
+AGGAATGGCTTGGGTTAACATACAAAGGAAAACCATAAAATATTTATAGCCTTTGCTAAC
+GACTTTATCTTTAGTAGCGACATCAGTAGACATGTAATTACCTTCTTTCTAAACTAATTA
+CTTATCTAAAATAATATTTGGTTTGCTGACGACAATATTTTTTTGCATTTGCTTAATTTT
+AATAGCTGCAAAAATTAATAATATAAAACCAATTGCTACAAAGAAAATAGTGCAGCACCA
+AGCAGTTGTGAAACTGGTAGCGCCTTTTATGACGCCAAATAGTGGGGCGCCAATTGCAAA
+ACCAACAGCATAGGCCAGGCTAATGTAACCTAAGTTAACACCTTGAGCTTTTGCACCAAA
+TAAACTTTTCGACATAAATGCAGGACCAGACATATAGCTAAAGACAGATAGACCACTTGT
+AAAGGCCCAACCCATACCAGCGTAGAAATTAATGCGATCGCCGTAAGGATGAAGGCTAAT
+AAAGATCATCATTAGGATAGCTATAATTAACATTATTCCTGCATATGCCATTGATTTTGC
+TGTACCGAACTTATCAAATAAATAACCCCCAGAAATGTTTCCGATGATGCCAGCAAGTCC
+AAAGACTGAGCCAATTATTCCGACCTCAGTTAAGGATAATTTAGTATCAAGAAAGGCCGC
+ATAGTCTTCATTTAATGAGGCTAGGCCTAAACCGATAATTAAAAATCCAATGCTGAAAAT
+CCAGAACCATTTCATGTGTAGAACTTGTTTGCCACTCCAGCCTTGAAATTCATGGGCTTG
+CTTTTGAGCAGCTTCGTGTCGGTTTTGTTCAACTTCTTGAGCAGAAGCTAAAATTTCATC
+TTTCTTTGGTACCCTAATAAAAGCTGCAATAATCAATCCAACTACTAATAGAGCAACAGC
+AAAAATAAAGAAAGGTGTCATCGAAGTTAAATGACCAGTCTTGGTATTACCAGTCATGAA
+ATGCTTTAAAATTTCCTGGGTAATAGGTTGCAAGAAAATATCACCAATCGATCCACCACA
+AAATGCTAGACCTAAAGCAACACCGCGTCCTTTAAATGGAAACCAGTGATTGATAATCCA
+AGGGACACCCTGACCAGAATAAAAGGTTGAACCAACCATACAAATAATTCCAGCCAAATA
+AAAGCTAGGTAGCTTTGTACTAATTCCAAAAATTACATATGCTCCAGCTGAAAGACAAAT
+ACCTATCAGATATAAAATCTTAAAGTTTACTTTTTGCAAAGCCTTACCAACTAATGGTGA
+AACTAAAGACCCTACAACAGCCCCAAAGGTAAAAATTAATGTATAAGAAGCTAATGTAAA
+ATGAAAAGTATTAACCAGAGGGTGAACAAATAAAGGCTGAATTAATTGGGCGATTCCATA
+TGGAACAGCTTGAGTTAACATGCAGAGAAATACCATAAAGTATTTGTAGCCTCGACTGAC
+CACCTTTTGTCTATCGTTTGACATCGTATCTCTCTTCTTTCTGACAAAATACTATTAGCT
+TGATAAGTTATATATTATTAAACACGTGAGCTTTGACTATAGCCACCTTTATTGTGGCTC
+ACTAAATCGAGTAAATCAAAAAATAACGACCTATAATGTTATTTAATAGGCATAATAAAA
+AGCCTATCTTTTTGAGATAGACTTTAGAAAATTATTTTTTTACATATCCTGCGATGTCAT
+CATCGTCAAAATCATAGGTTAACTTCTTATCATATGCTTTTTCATATGCTTTTTTCTTTT
+GTAGATAATCAATATCACGCATTCTTTTGGCATTTTGATCAACTGTTAGACGGTCAACTG
+GATAAATTGTTGGTAAAACGTGAAGAATGTAGCGAGTTTTGTGGAATTCGCTGCTATTTT
+TCTCCATTTCAGGGAGGTCCTGAATTTCTACAAAACAGGAAATAATTGGAACGTTGGCCT
+TAGCTGCGTAGTAGTAGGCGCCCTTTTGAAGAGGGCGAGGTTTTCGATAGTTATACCACA
+TTTCTTGCTCCGGATAGATCAAGACCCAGCCCTTTTTATCAAAGACTTTTTGCAAATGCT
+TAGGAAATTCACGCCCCAAATATTGGTAGCTTTGAACAATTGGAATTGCATTAATGTTGT
+TCATTAGAAAACCAAAGAAACCGGGTAATTTTAAATTAGAATCTTCAATCACAACATAAA
+GTTTTTTGTGACATTTGTTGGCTAATTTCTTGATTGGAAGACTATCGGTTTGCTTGAAGT
+GATTACTGGTAATAATTGCGCCATATTTAGGTCCTTGAGCCCGCTTCTTATTTTTGATTT
+GCGTGTGAGCCATCAAAATTAAAGTGTCAATATTAATAATACCTTGAGCAATAATATTCT
+TTAGTTTATGACTAAACTTCTTTTGTTGTTTCCAATAATCGTTAACGAGTTTGATTCTTT
+CGCTTTTAGTCAGGATAGGATCGCCTAATTCGACTTTGGCATGCATTTTTCCCTTTTTAA
+CGGCTGTTTTGATGTTTTCGATAACTTGCGCGCGATTTTCACCAATAATCATAATTTCAC
+CCTTTCGCCTTTTCTTTTAATTTGAGCCCAGTTATTTGGATCAAGTGCCGTGCTCGCCTC
+TTTTTCAAGCATATGATCTAATTTTGCCCGATTTTCAGCTCGCTCTTGATTAGTATAGTT
+GTCTAACTCTGATTTTAATTCCTCATAAAAAGGTGTGCTAGAGGCATATTTCCAGAAATA
+ATCATTATATTGGACGTCTTTAAAGTGCCAAGGTTTGAAAAATAAATTATAGTGAATTAG
+CCCTGGTTCAGGAATGGGGGCGGTATTTTCATTAGGCATTGCGTCCCAACGTGGATCAAG
+ATGTAAAATTCTTCCGTCACAAATCTCATTTAGGTAGTCTTGATCAGGAGCAATACAATC
+AAAGTGATATTGCTCAAGTAAATGCATAAAGTGATCGATAAAGTGTTCATCCCTAAAAGC
+TTTAGAATTTAAGACTAACATCCCAGAATTAATATATTTCTTTGGATCGAGAGCTAGAAC
+TTCTTTAATATATTTCACCATTTTATCTACATATTGAATCGATGAATCTGTACAAGCGGC
+GAATAGATTATTACCTAAGTCGTTATTATACAGTTTAGCAATGTCATCAACGACGACTGT
+GTCACTATCAATGTAGATTGCTTTATCATATTGTGGAAATAAGTCAGGGATAAAGAGACG
+ATAAAAAATAGACATTGTGAAAAAGTCTGCCCGGAGATAGTTTTCTTTACGATTTTGGAT
+CGGTTTTACCAGTTTTTCATCAATATGGAAAAATTTAACGTGCACATGGTCATTAGCAAA
+AGCTGCAAGTTGCTTTTGGTGTTTTTCAGACAGGTCTTGATTTAGAAAAGTAACTGTGTA
+ATCTTTTTGCGGATTAGCATTTTTAACCAAGGAGTTTAGCGAAACTGCCGCATACTTGGC
+AAAATCATCACTAATACTATAAAAAACAGGGATAGTCATTTTTAAGCCTCTTTATATTTT
+TACAGATGTCGTTTTCTTAACTTTCGCCCAAGTTACATCTTCATCTTTGATTTCATCAAC
+TTTTTTAATCATCCAATCAAGGTCGGCACGTGCTTTTTTACGGTCTTCATCGGTGAAGTT
+AGCTAATTGTTCTTTTAGTTCTCCATAATATGGAGACTTTTTAGCAACATCCCAGAAGTA
+TTTGACATATTGAACATCTGCGAAATGCCAAGGCTTAAAAAAGAGATTATAATGGACAAT
+TTTAGGATTTTTAATTTCATCCATGTGTTCATTGGGCATTGCATCCCACTCAAGGGGCAA
+ATGATAAATTTTGTCTTCACAAATTTCGTTCATATAAGCTTGATCAGGATCGATATTATC
+GAAATGATACTTTTCAATTAATGAATAGAATTTATCAACAAATTTCTTATCTCTAAAGGC
+TTTCATATTGAAGAGAATAACGCCGTTATTGATATATTTTTCTGGTGGAAAAATACCTTG
+GCATTCCTTGATATAAACTTGAAGTGGCTTAATAAATCTGATTGACATGTCTGGTACACT
+AGCAAACATGTTGTCGCCGATTTCGGTGTTGTAGAGTTCAGCAATGTCAGTACAAATAAT
+AGTATCAGCGTCTAAATAAACAGCCTTATCATACTGAGGAAAAAGGTTAGGGATAAATAA
+ACGGTAGAAAATAGACATCGTGAAAAATTGTGCTCGTAAGTAATTCTCTTCACTGTTGTG
+AATCGGAGCTACCATTTCATCATCAATATGAAAAATATTAACATGGACATTTTTAGTAGA
+AAGATCTTCTAAATCTTTTTTGTGCTTATCGCTAATGTTTTGAACTAAAAGAGTAATGGT
+ATAGTCTTTGTTTTGATCCACATGGTCAATTAGTGACTGAATTGAAACGGCCGCGTAGGG
+TGTGTAGTTGTCGCTAATTGTGTAAAAAACAGGTATAGTCATCAAAAAATAAACTCCTTA
+TATATTAAATGTTTCTAGGCCCGCTTTAATTGTGACCTAAGCTCTACGTACTGCTTAAGT
+AAATCATCATATTCATGTAATTTCAAGACGCTGTGCACTCGCTCTATATCCCATGGTTTA
+ACAGTTAAAGTATGGAAGTATGGCTTAAAACGAAAGCTAGTCGTGAAATGTTGAATTTTG
+GTATCTGGTCGTAAACGATATTGTTCATTGTAGCAACGTGGAGCAATTTTCTTCTCAGTA
+GCAAGTTTATTTAGAGCAGACTGATCTGGAAGAAGCATTTTTTTATCACTCATTTTTTCT
+CTTACTTTGGCAAATAATTGTGTTTTTTTAATTTCAGCCATGTTAAGAAGCAAGACGCCG
+GAGTTTAGGTAATCAAAAGTCTTGTGGGTATGGATATTGTGAAAGAAGAACCGACCCCAG
+AAGTCTAAAACACCGACTAGTTCAATATTAGCTAGATCTTGATTATAAAAGTCGCTAATA
+TCTTTACGCACAATAATATCATCGTCTAAATATAAGATACGATCAGGAATCTGTGGTAGT
+TGGTCCGCAAAGAGACGCAGCATTGCATATGGCGTAAAACGAGTTTCCATATTTGCGCGT
+GGAGGTTCTTTTTTAAATAATTCAGTACAATCGATTAATTCAGCAGTATTGTTAGGATCC
+TTTTCTTTAAGCAATTTTTTAATTAGATTAAAAGCTTGTTGGTTAAAAGCTGTGTATCCC
+TCTGCGTGCATCGTCAAAATATAAAAGTGCAGGGGAGTTGATGTGTTTTTTAGTAAAGAC
+AGCGTTGTAATTAAAATACCATCTTCGGCATGAGAATCGCCGCAAAACATAATATTCATT
+TTTGTCCTCCAATTTTTCGCTGCTGGTAGCGATAATATTCACAGTTACTCAATTTTGAAC
+GGTTCTTCAATTGAGTAAATATTTGATCATGTAGCTTTTTTTGTTGCAGTTTTTTAGGTA
+GAGAAGTATCTGGAAAAAAGGGGCCATCAATATAAACAGTAATTCTAGGGTGCTTGCTAT
+ATTTTCTTTTCTGGTAGGTCGTTGTCATAACAAAGCTTGGCTTAGTTGTTTGAACTGGAA
+AGTTAAAACTAGTTGCTGGAAATGGACGAATATCAGTATAGTAGGGCCAAACATGAGCTT
+CTGGATAGATAATGATATGGGCGTTTTCCTTAATTAGAGTATTAACTGCTTTAAGCAGAT
+GAATTGCTTGCTTAATATTTTTGCCAACTGGTAATCCTCCATAAGGCAAGAGAATTTTGC
+CAATTATTGGAATTCCCCAGTTTGCTTGATTAGCAATTGCATAATAATCTTTCCAGCCAA
+AGAGGGTTAAAGGCATAAAGACGTCGTTAACCATTTGAGTGTGATTTGCATAGACAAAAT
+AGCCCTGATGCTTATATTTAAATAACTTATCTCTCCCTATTACTTTGACATGCATTCCGC
+CATAAGTAAAAAGATAAGCAAAGCCAGTAGCTAAAAAACGCATTAAATAGTTAAGAGGTG
+TGCGTTTAATTATTTGATAATCGCTAGGTAAGGTAAAATCTTGTTGCTTACTTTTGACAA
+TGTCGTCAGTTAAAGAATTATAGTAAATAACATTACGTTGAGATGGTTTAGTATTCATGA
+TATTAATTATAAAAGAAGTTTAAAAACAAAAAAAGACATCGCTTCAGCGATGTCTTATAA
+AATATGGGTGGTCAGGGGATCGAACCCTGGACCCACGGATTAAGAGTCCGTTGCTCTGCC
+AGCTGAGCTAACCACCCAATTGGATAACCAACAAATAGTATTATGCCAGGAAAAGAACTA
+AAGTGCAAGCTTTTTTTGCATAAGTTTAAAAAAAGTGTGGAAAACAGTATAATATAGTTA
+TTAATATTGAGGAGGCATCATTTATGCCAAAAAAGATTTTAGTCGTTGACGATGAAAAAC
+CAATTTCTGACATTATTAAATTTAACTTGACTAAGGAAGGCTTTGATGTCGACACTGCTT
+ATGACGGCGAAGAAGCGGTTAAAAAAGTTGATGAATATGATCCAGACTTGATGATTCTAG
+ATCTAATGTTGCCTAAAAAAGATGGCCTAGAAGTTGCACGGGAAGTACGTCAAACTCACG
+ATATGCCAATTATTATGGTAACTGCGAAAGATACTGAAATTGATAAGGTATTAGGACTCG
+AGATGGGTGCAGATGACTATGTTACTAAGCCTTTCTCTAATCGAGAACTAGTTGCTAGAG
+TAAAGGCAAACCTACGTAGACGTGATTTAACCCAAAAAGCTACTGAAGATGATGAAGATA
+AAAATATTACTATTAGCAATTTGGTAATTATGCCTGAAGCCTATATGGTCGAAAAAAATG
+GCGAAAAAATTGAATTAACACATCGTGAATTTGAATTACTTCATTATTTAGCTCAGCATA
+TGGGTCAAGTGATGACTAGGGAACACTTGCTGCAAACCGTTTGGGGCTATGATTACTTCG
+GGGATGTTAGAACTGTTGACGTAACTGTTAGACGTTTACGTGAAAAAATCGAAGATAATC
+CGAGTTCGCCAACAATTTTAGTTACACGGCGTGGAGTAGGATATTACGTTAAAAACCCAT
+CAGATGAATAAGGATCAAAGTCACTAGTAATAGTGGCTTTTTTTGCAATTAGGACAAATG
+AAGAAAATAAAAAGTGTATTAAATTCTATCAATTTTAAAATCGCAGTAATTTTTATGCTG
+CTTTTATTAGCAACGATTGAAGTGGTTGGTGCGTCTTTTACAAGGCAACTCGAACAAAAC
+TCAATTCAAAATTTTGAATCATCAATTCAAGTTCCAAATATTATTACTAACCAAATTTCT
+AGCCAATTAAGTAGGGCTAATTCTAAAAAGGCTAATCAGCAGTTAAGCCAGATTATCTCA
+AACTATAATTTGGGCGATATTAGCCAATTAATGGTAGTTGATAATAAGGGAGTAATTAGA
+GCTGTTTCAAATGTGAATGATCAAAACCGTATTGGACAGCGAACTAGTAATGTAGATATC
+AAGAGTGTACTCTCAAATGGAAAGCAAGTTTCAAAAGTTATTAATGACAATGGAAATTAT
+ATGGTGCAAATTTCACCTTTGACTTCTGCTAATGGAACTAATACTCCAGTAGGAGCAATT
+TATGTTCGCGCTAGCTTACAAGGTGTCTTTAATAACTTGAGACAGGTATCGATTTACTTC
+CTGATTGCTTCGCTGATTGCAGCTGTTTTGGGAGCAATTGTAGCCTTGGTTATTTCCCGG
+GCAATAACTAGACCTATTGAAGAGATGCGTAAACAAGCATTAAGAGTTGCAAATGGAGAC
+TATTCTGGGCATGTTAGAGTTTATGCGCAAGATGAGTTAGGTCAACTAGCCGAGGCTTTC
+AATACTTTATCAGTAAGAATTGAAAGAACTCAAGAAATTTCAGACAGTGAGCGAAGACGA
+CTAGATAATGTCTTAACACACATGACAGATGGTGTTATTGCAACAGACAGACATGGAAAT
+ATCACAATTATTAATGAAACAGCACTCGATTTTCTAGGAAAAACTGAAAAAGACGTTATT
+GGAAAGCCAATAACTAATTTACTTGGATTAAAAGATGTTACTATTCAGGACTTATTAAGT
+ACTCAGCAAGAATTAGTTGTTCGAGTTAATGATAATACGCGCGATGAAATGATTTTGCAT
+GCTAACTTTTCTTTGATCCAGCGTGTAACGGGGTTTGTTTCCGGCTTAGTTTGCGTGCTT
+CATGACATTACCCAACAACAAAAAAATGAACGTGAACAACAACAATTCGTTTCAAATGTT
+TCACATGAGCTTAGGACGCCGTTAACAAGTTTAAGAGCATATGTTGAGGCATTGAATGAT
+GGGGCATGGAAAGATCCAAATATTGCACCACAATTTCTGCATGTTATTCAAGATGAAACT
+GAGCGAATGATTCGAATGATCAATGATTTGCTTAGCTTATCTAGAATGGATCGAGGAGTA
+GCGAGGATGGATTTAGAATGGGTTAACTTAAATGACTTTGTTAACCACGTTTTAAATCGT
+TTTGATATGATGCTCAAGTCTGATTCTGATAAGATGCACAAAAAGAAATATACGATTAAG
+CGTGAATTTCCTCATCAAGCCTTATGGGTTGAAATTGATACTGACAAGATGATGCAAGTA
+ATTGACAATATCATGAACAATGCTATCAAGTATTCACCTGACGGTGGCGTCATCACAGTT
+CGCCTATTGCAGGCTCAAAAGCACGTTATCTTAAGTATTTCTGATCAAGGATTAGGAATT
+CCAAGAAAAGATTTAAACAAAATCTTTGATAGATTTTATCGTGTTGATAAGGCGCGTTCT
+CGTAAACAAGGTGGAACTGGTCTAGGACTGGCTATTTCTAAAGAAATAGTAGAAGCACAC
+CATGGTCGAATTTGGGCAGATAGTGCTGAAGGAGCCGGCTCAACTTTCTACATTTCTTTG
+CCATATGAAGCAATTAGCGAGGAAGGAGAAAACTGGGATGAGGTTTAAAGATAAGTTTTC
+TAGAATTGCATTACGAGTTAGCTTAATTGCAATGGTTGCACTATCAATTATCTTGTCAGC
+TATTATTTGGGGTTCTGATGCACGATTCTCAAGGATTGAAGAGACATCTAATCAAACTCA
+AATTAAAGATTTAGGCCAACGTTCTTTAAGAGATATTTATTTACCTACTCAAACTTTTTA
+TTTTAAAGATAAGCAAATGTATCAGGTTTACGATACTAAAAATAATCTTCCGCTAGAGTT
+TTCAAAATTAACTCAATCAGTTAAGCCACTATTGCCAATCAGAGTTTGGTCTAGTCAAAG
+TAAATATGAAAAGTTATTAAAAAATCCTGACTATGTTCAGTTAACATATCCGGATCAGAT
+AACGATTTCCTTATTCTTAACTAATGTAAGAAAAACTGATAGTCGGGAATTTAATCGCTT
+TTTTGTGCCAGCTCGATCCAGTAAGTATATTTATTTAGGCAATGACGAAAACTATACTAT
+TTATCGAGTTCGTCTAAATGATGTATCGTTTGACAATTTGGTGGAACATATTCAAAGCGC
+TAAAACACAGATGCCAGTTACGCTTCAAAAAGTTCATGATGATTATTTACTTTTCTATGA
+AAAGGATTTAAGTTTACCAACATACAGCTATTTAACTAATGAAGAGTCAGATTCATACTT
+TGTGTATCGCTTGTTAGGCTCTAATAATCCTACCCAGCATAGTTCTGGCGAAAGCATTAC
+ATATTCTAATGGAGTATACGAGCGGTTGATTGCGGCAAAACATACTCATAATTATGAATA
+TGTTGATTATCAACAGGATCAGGTTCCGAAGACTATTAGTCGAAAATTAAATGATAGTTT
+ATATTTTGTTCGTAAAATTGGATTATCTGAGCCAGATTTAAGGTTCTTTGATGCTGATAA
+TAATACAGTTATTTATCAAAATTATGTTGAAGAATATCCGATCTTTTTACCAGGGAAATA
+TAAGATGCGGGCGCAAGTTAAGTTTGCTTCTAATGGAATGACAATTAACTTTAATAGCTT
+AGACTTGCAGATTCCAATTCCAACTAATGGTGAAAAGAAGACGCTTATTCCGACTAATGA
+AGCGATGGATGAATTATATCAAAAGGGATATCACCAAAAAGATATTGAGCGCATTGTTAT
+TGGCTATACAGCTAAGTCTGATAATAGTAAAAATAAAAAATTAGTAGATCTAGAACCAGC
+CTATTATGTAAAGATTAATAAGCAGTGGAAGACCCTAGATGAATGGCTAAATATTAATAA
+TCAAATTACAAATTCTAGAAAGGAGGGGCTAGTAGATGGACTTTAAGAGAATTGAATGGA
+TTTTTTTAGTCGTATTTATTGGAATTAATATCTTTTTGGGTATTGAGCTTTGGCAAACAC
+CGACGCTTTTATCTGCTGGCTCTACTCCAATTCAAACTGATATTAAAAGCGAAACGAGTG
+CAGATCAGATAACTATCCCTAAAGTTGATGATAAGCAAGATGATGGGTATTATTTAGCTA
+CCAAAGTGGACAATTCTTGGACAAAAAAAGCAGCAGCACAGGTAAATCAACAAGTAGAAA
+CTAATACAAGTGAAAATAGTATTTCAGTTAATTTGAACAAACCAATTACTCTGTCGAAAG
+ATTCCAAAAAAGCCCTGAAAGAAATTATTCACTTTAAAAATAATAGTCAAAACGTGTATG
+AGGGTAAAGATTATGTCTATCTTTCAGAATTATCCGAGGGAGATGATTATGTCTTTAATC
+AGAAAACAAAGTATGGAGAAGTTTTTGCAGCAACTGCTCTATTGCACATTATTGTTAAAA
+ATAATCAAATTGTATCGTATTCGCAACGCTACGTTAGCAATTTGAATCCAGTACGTGAAA
+GACAAAATACAATTAGTTCAAAGGCTGCTGTAAATTCTTTATACACTTATAGTGAATTGC
+CAAATAATTCTAAGATTATCTGGTTAAAGCAAGTTTATACTAAATTGATCACTGTTCGAG
+GGAGCGAAATTTATATTCCTACATGGGTAGCTGCGATTGAAAACAATAATTCTCATACGA
+TGACCCTTAAGCGCGTAAACGCATTTACAGGGACAATTATCCAAAATAATATTGCTGCTG
+ATGATTCAAAGGAGTAGAGAAATTTGAAAGTATCAGTTTTATCAAGTGGTTCAACAGGTA
+ATTCTACATTGATTGAGACTCCGCAGCATAAAATCTTAATGGATGCAGGTTTATCTGGAA
+AGAAAACTAAGGAATTACTAGCACAGGTAGGCGTTGATATTAAAGATATTGATATGGTAT
+TTATTAGCCATGATCATACTGACCATTCTGGTGGATTAGGCGTATTGATGAGAAGATATC
+CTAAAATTTCAGCCTATGCGAATTCAGGTACTTGGAATTATTTAATTGAAAGCAATAAGA
+TCGGTAAATTACCTGTTGAACAAATTAATACGTTTGAGTCTGGTATAACTAAGACTTTTG
+GTGATTTGGACGTGACAAGTTTTGCGACGAGTCATGATGCGGCGCAGCCACAATATTATG
+TCTTTACAAGTGGTGGGAAAAGATTTGCGTGTTTAACAGATACTGGTTATGTTTCAAGTA
+CTGTTAAAGGTGAAATAAAGGATGCAGATGGCTATTTAATGGAATTTAACTATGACGATA
+TGATGCTTAGAAATGGCCCTTATTCTTGGTCTTTGAAACATCGAATTATGTCTGATGTTG
+GACATCTTTCAAATGATCAAGCAGCAGACACCTTACTTGATGTAGTTTCTCCCAAAACTA
+AACATATTTTTTTAGCGCATCGCAGCCAGCATAATAATACTCAGTATTTAGCGCATGAAA
+CGGCTGAAGACTTATTGGTAGCTGGGGATGCAAATTTACCAGCTGATGTTAAAATTATTG
+ATACTAATCCAATGCAAGCTGGTTCTTTAACGAAAATATAAATTTTTAGCAAATAATTTG
+ACTTGAATTCATAAAAAATTCAAAATTTGTGATTAGGCTAGAAATGAAGAGAAAAGGAGA
+AATTTTTATGGCAGAAAATAATACTAAACACCCTACTAAGCATAATGCTTTAATTAAAAC
+TGGTATTGTTGGAGTGGTTGCCGGACTTCTTGGGGGTGGAGTTGCTTATGCAGGTTTGTC
+TCAAGTTAATGGGCAAAATGCACCACAAACAAGTGTTGTTCCAACGACAAAAGTTGAAAA
+GTCTAGCAGTAAAAATAGTAGCCAGATGACTAATGCCTTTAATACGGTAAAGAAATCAGT
+TGTTTCTGTTGTTAACTTAAAGAGACAAAGTTCATCTTCAAGTAGTGATCCGTTTGGTAT
+TTTTGGCTCTGACAGTTCTAGTTCTTCAAAGAAAAATTCTAAGTCTGATTTGGAAACTTA
+CAGCGAAGGTTCAGGTGTTATTTACATGAAGTCTAATGGCAAAGGCTACATTGTAACTAA
+TAACCACGTTGTATCTGGAAGTGATGAGATTCAGGTCATTTTAAGCAATGGTAAAAAGGT
+AACTGCAAAAAAAGTAGGAACTGATTCAGAAACAGATTTAGCTGTTTTAACCATTGATGG
+AAAATATGTTACTCAAACTGCGCAATTTGGCTCATCTAAGAATTTAGAGCCAGGACAGCA
+AGTTATTGCTGTTGGTTCACCTTTAGGTAGTGAATATGCTACAAGTGTAACTCAAGGTAT
+TATTTCAGCTAAGAATAGAACTGTTGATGTAACTAATTCTGCTGGACAGGTTACTAACCA
+GGCAACCGTTATCCAGACTGATGCTGCTATTAATCCGGGTAACTCAGGTGGTCCACTTGT
+GAATATGTCTGGTCAAGTAATTGGGATTAACTCAATGAAATTATCCTCTTCTAGTGATGG
+TACAGCTGTTGAGGGAATGGGATTTGCAATTCCAAGTGATGAAGTTGTTTCTATTATTAA
+TCAATTAGTTAAGAATGGAAAAATCATTCGTCCAAAATTAGGTGTAAGAATTGTATCAGT
+TGACGAATTAACAGAGTATGGCCGCAAGAAACTTGGTTTGCCTGATAGTGTTAAATCTGG
+TGTCTATGTAGCTAGCGTTACTAAGAATGGTAGTGCAGATAAAGTAGGAATTAAGTCACA
+TGATGTAATCACCAAGATTGATGGTAAAGATGTTGATAGTGTTGTTTCACTACATACTGC
+GCTTTATACACATAAAGTTGGTGATACAGTAACACTTCAAGTCGTTAGAGACGGTAAGTC
+ACAGAATATCAAAGTTACTTTAAGTTAAGTGAATATTATTAAATAGAGATAAAAAAGCTA
+TGATTATGCGTTTTGTAAGCGGTGATCATAGCTTTTTCTTAATATTTAAAATGTGAAACG
+TAATAAAGTTCGTCTTTTTGAATTGTCAAGAACTGAAAGTTATCCAGAAGATTGTGGGAA
+AATGTGGAAAACTCTGTGGATTGTGCATAACTCGGTCAAAGTAAAAATAAATAGTGTGGA
+AAACCTGTGAATTGTGTGTAAATAAAATTCTAAAATTAGCTGTTCTGAACGGCTGTTCAA
+GTTGATTATGTAGGGAATAGACCCAAAAGTTTGGAAAATTAGTAGTATTTATAAAAATGT
+GGAATAAATTTGCTAAAAAAGTTATCCACTTTTTTAGAAACCACAATTTATTGATAATTA
+ATTAAGTCAACCACTAAATATAGTTTTCGATAATCCACAGCTAGGGGAAAAGTGATGTGG
+ACGCTATGTCAATTAGGGGATAAAATTAAAAACTAGATGCGTGAAAGGTTAGATAGTTAC
+AATGAATATCAAAATTGTTTGTGTAGGTAAACTAAAAGAAAAGTATTTTAAGGATGGTAT
+TGCTGAATACGTAAAGAGAATGGGGCGTTTTGCTAAAGTAAAAATAATTCAAGTACCAGA
+CGAAAAAGCCCCCGAAAAGCTAAGTCCTGCTGAAATGGAGCAGGTCAAAGAAATCGAGGG
+AAAAAGAATTCTAGATAAGATAAAAGATAAAGAATATGTTTATGTAACGGCAATTAAGGG
+TAAAGAAAGAACTAGCGAAGACTTTGCTAAAGAGCTAGCTGACTTAACTACTTATGGACA
+TTCAGACATTACCTTTGTGATTGGAGGAAGTTTAGGAACAAGTAATGCAGTAAACAAACG
+AGCTGATGATCTAATTAGTTTTGGTAAATTTACAATGCCGCACCAATTAATGCGGTTAGT
+TTTAGTTGAACAAATTTACCGTGCCTTTATGATTAATAGCGGTAGTCCGTATCATAAATA
+ATTATTTTATAAAAAATAAGATTGGTTGCAGTAGGATTAAAATACTACTAAAAATAAGCC
+AGTCTTTTTTTGTTAGGGCAATTGGCACGATGACATTTCGTGGTTTATCTTCACGATACC
+CATGTGAAATCATTCCTTCAGCAAGGCTGTTTGACCAAGAAATAGCTGCTAAAATCGCTT
+TAAAATATAATGTTGGCGAATAAAAAGAGAGATGATAATGCCTCATGTCTCCAACTAAGC
+GAATGCGATTAACTTCAGCATGGATTTTAGGAAGTACGTTGAATGCGGCTAAAGTCCCAT
+AGGCGAATTTACTCGGTAGTTTAAAATTTTGCTCTAATGAGCGAGCGAGTGAAAGAATAC
+TAGTGGTTTCAGTAAATGTAGCTCCTAAAAATACATAAGCGTAAATTCGTGTAAATAAAA
+CGCTGGCATGGTAGAGACTATGACCTGGAGTAAAGTAATAGATCGTAATAAAGACTACTA
+AAGCTGCAAATAATGGGATTAAAAAGAGCAAGAGTAGTTTTTTAGGGCTGAGATGCTTAA
+ACGTGAGATAGCCAAGACTAGCTATAATAATTATTATATTTCCAACCAAATTAGGAATAA
+GCGATATTTCAAGTGAAATAATTAAAATCAAAAATAGTTTCAATCCGGGATTCATGTTGT
+TTACCTTTTTAATTAGTGTAGAAAAGTTTCTGATCTTTGATAGTTAAGTGATAGTCACAG
+AGATGCTGAACTTGTGCAAGTTGGTGACTAATGACAAGCAAGGTGTGGTTAGAATTAAGA
+AAGTACTTTTTAAGCAAATAAATGACCTCTGAGACGCTTTCTTGATCTAAACCACTAAAT
+GGTTCATCTAGAAGTAAAACCTCGGGATAAGCCATTAACATGACAAGAATTTGCAATTTT
+CTTTTTTGTCCTCCAGATAGAGAATAAACAACTTGTTCGCCTAAATTTTCTAAGTTGAGT
+TCAGTCAGCAGGTGCTTGAGCTCAGTTTTATTCAAGGAAGGGTTTTGATTGTGTTTTAGG
+CTAAAGTCTAATTCTTCCTTTACTGTAACATTTAAGAATTGGTCATCTGGATTTTGAAAA
+AATTGTCCTACTTTTGCTAGATAGGGATGCCGGCGCCATTTCTTAATGTCTTTACTTTTA
+AATATTAATTGTCCTTGATACGGAATAATTTTGGTTAGAGCTTTAAATAAAGATGTCTTA
+CCGCTTCCGTTTTCGCCAGTTAATAAAGTGGCTCTTCCGGAGTAGATTTTTAGATCAGTT
+GGAGAAATTAGTTTTCTTTCTGGAAAAGATAATGAAAATGATTCAAGTGAAAATACTGGA
+TTTTGTTTTAAGTCAGGAAGAGAGAAAGTTAATGCTTGATTTTTTAGCGTGTTTTCAGGC
+AAAGTAATAGTTTTAATATTTTTGTCTTTGATAGCCAAGACCGTGGAAACTAGCTTTTCA
+TAGCCAGAGAAATTATGGTCGCTAATTAAAATTGTTTTTCCTTCTTTGTGAAGTGCAGCT
+AAGCAAGTTAGTAGAAACTTCCGATTATGAGAGTCGCAATTAGCAAAAGGTTCATCTAAT
+AAAAATAAGTCGCTTTTCATGGCAATCAGGATAGCTAAGGCAACGCGCTGCTTTTCACCG
+CCTGAAAGCTGAAGAAAAGGTTGGTCTAATAAAGATGAAATATTAGTTCTAGCACTTGCG
+TAATTAATACGCTTTAAAGCAGCAGTACGATCAACTAGTTCATTTTCTAAGGCAAAAATT
+AGTTCTTCTCGAGGAGTCGCCATCGTAAATTGTCGGTTAGGGTCTTGAAATACCATGCCC
+CAATTAGTGAAAGGCTGTTTTAAAGAACCAGCAGTAATTTTGCCATTGAAAGTTGGGTCA
+AGGCCGGAGATGAGCTTTAACAGAGTTGATTTGCCACTACCGGTTTGACCAGTCAATAGA
+ACAAAATCACCTTGATTTATGGTTAAATTTAAATCTTTAAAAATTGGCTGATTTTGATAT
+TGAAAAGATAGCTGATTAATTTTAATTTGTTTGGACGACATGGGCTTTTACCAAGAGGTT
+AATGATCAATTTAACTAAAACGCAGGTAAACAAAAGCATTGAAAGCCAACGAACTACGAA
+GTAGAAAATCATGTTAAAAGTTGAAAAATAGCTATAGCCATTCTTAATGAAGTCATACAG
+GTAGGTAACGATTGTTGTCGTTGTAGCAGATAAGAAAAGGGTGAACCAGTTGTAGCGACG
+GTAGCTAGTAAGAGTAAAACCTAATTCGCTACCTAAGCCTTGAACAGCTCCAGAGATCAG
+ATTTACGGCTCCCCATTGTTCTCCAGCGATAAGTTCAACGCAAGAACCTAAAAATTCTCC
+TAGAAATGCAGCCCCAGGTAGTCGAACTAAGAATCCCGCTAAAGGACCTGCCATACACCA
+GATTCCCATCATAATATCATTGGCTAACATTCCATAACCAACCGGTGTAAGGAGCGCAGT
+TAAGACATTATAGAGGCCGTCACTAACTAAGTAAATAAAGCCAAAAATAATAGCAATTAA
+AGCAATTAGGATAATATCTCGAACATGTAATTTTTTCATTTTTTCCTCCCGAAATAAAAA
+AGCCACCTCAAAGAGGTGACTAAATAAAAGTCTAAAAATAAATCATTTTCCCTACGCTGA
+TGTTAATCAAACAGGTTCAATGGGTATATTCTCAGCGATCTGGCACCCCAGTTATATTTC
+TAGGTTTAGCTTACGCTTAATAAGCCGAAATGACAATTAAAAATAGCAAAAAGGTTATAA
+TTAAAATAGAGTGAAAGCAAAGGGGACCGGTTGAGATGGCAACAGCGACATTAAAAAATT
+ATTTATCAAGTTTAATGCAGAATACGCAAGGTACTGAAATAGAGATCCGTACTGAAAATC
+TTCTTTTGCCATATAGTCTTTATTTAGAAACAGTGCATTATGATTTTACTGAATATCAAT
+CTAGTACTAGTCAATTAATTTACTGCTTTGCGGGTAAGTGTGAGGTTGAAATTAATAATA
+AAACTTTTTATTTGACGGCAGGAAATATTTTGCTAATTGAAAAAGACACTGACTATATAA
+TTAAAGTTAGTGATAAAAACGCAATTATTGTTAAGTTTAAGCTAAAGAGTAATTTTTCAT
+GGCAAAAACAAGTAGAACAGTTAGATGCCAATACACCCACCGAACAAAGATTGAGCACAT
+TATTTTTAAAAAAGTTAAATCAAGATAGTGCTTTTTTATTTACAACTACCTCTGTAACGT
+GGGGTAGTCAAAACTTGAAAGGTATAATTCAAGACTATCTTAATAATGTCGCTTTTAATG
+GAACAATTGGCTTAGAGCTACTTAAAATTATAATCTTACGCAATTTGCGCGAACAAAACT
+TTAAAGCAAATGAAGTAAAAGAAAGTACATTTAAAGATGAAGCGTTAGATCAATACATCG
+ACCAACACTATAATGATATTAGTTTAGCGCAAGCTGCCAAATATTTTGGCTTTAATCGTA
+ATTATTTTTCTACAATGGTAAAAGAAAAAACGGGAAAGAGCTTTGTTGAGCATGTCGATG
+AAAGAAGGATGAAAGAAGCTAGAAGGTTATTGGCCAAGCCAAATGTTTCATTAAAAGAAA
+TAATTGAAACTATTGGATATTCAAGCAAGTCGTTTTTCTATAAGAAATTTAAGCATTATT
+ATGGCATGACTCCAGCAGAAATGAGAAAGAGACTATTTAGAGAGGCTCATATCAATTTGA
+AATAATAGAGTACACAAAAAGGGATGCCTTGTGCATCCCTTTTATTACATGTTTTCCAAT
+CTCTTAATTCTGTCTGCTGTAGGCGGATGAGTATCAAATAATGAGCTCAAGCCACGCTTA
+TGAAACGGATTTTCGATGTATAAACCAGCGCTTGACGGATCTGGATCTTTCATTGGCTCG
+CTATTTGAAATCTTTTCTAAAGCTGAAATTAACCCTTGAGGGTTTCTAGTAAGCTCAACT
+GAACTAGCATCAGCTAAATATTCACGATTACGTGAGAGAGCCATCTGAGCTAGTGCAGCA
+GCAAGAGGTCCTAAAATTAATGTGAAAACAATGGCCACTATTTTAAAAATTGTTTCTAGA
+GAGCTAGAGTCATCGTCATCACGGTCAGAATTGCCGCCCCACCACCAAATACGGGACGCA
+AAACTAGAGATAAATGAAATTACAGCAGCTAAAGCTACTCCAATTGTAGATACTAAAATG
+TCATAATTTCGAATATGAGAAATTTCATGGCCAAGAACACCCTCTAATTCACTTCGATTA
+AGTCGCTTTCTTAATCCAGTAGTAACAGCTACGAAACTGTGCTTAGGATCGCGCCCAGTT
+GCAAAGGCATTAGGACTTTCATCGTTGATAATAAAGACTCTTGGCATTGGAACCTGTCCC
+GCAAGTGCCATATCTTCTACAATATGCCACAATTCTGGATCATCTTCTTCATGAATCTCT
+CGGCCATGATTCATGCTCATGACTAAATTTCCCGGATTTTGAAGAACAATAAAAAGATAA
+ATTAAGCTACCGATTAGGGCAATTACAATTCCTGATAGCGGTTCACCGTTAATCAAATAT
+CCTAACCCACCACCAACAAGAGCTAGAATAATAACGAATATAACAAGCAAAAATGCTGTT
+TTACGCTTATTGCGTGCTATTTGTTGATAGAGCATTGATAGACCTAGAATTTAACTTTAG
+GCACAGCTTTTTCTTCAGTTGGTGTTTGAAGGTAGTCCATATTCTTAAAGCCGTGAATCT
+TAGCGACTAAGTTAGATGGGAAAGTTAATAGTTTCTCGTTAAACATAGCAACAGTTGAAT
+TGTATAACTGACGTGAATATGCAATCTTATTTTCAGTGTTTGTAAGTTCTTCTTGAAGTG
+ACATGAAGTTTTGATTTGCTTTTAAGTCCGGGTAATTTTCAGCTAGAGCAAAAATACTCC
+TCAACGAATCAGTAATTTGGTTAGAAAGTTTAATAGCTTCTTCGTGATCGGAATTAGGAA
+TATTTACTAATTGATTTCTTAGAGCAACTACTTTTTCTAAAGTGCCGCTTTCATGTTTGG
+CATAACCCTTAACTGTTTCAACTAAGTTAGGAATTAGGTCGTTACGACGTTTTAATTGGA
+CATCAATTTGACTCCACGCCTCGTCAGCATGAACTTTAGCTTTTTGCAAGCCATTGTAGA
+TACCAATATAAACGGCCACCAGTAAAATTAAAATGATAATAATAATCCATGTTAAAGTCA
+TAGAAATAAATCCTTTCTATTATCATAAAAATATGGTTAGAATGTTAGGAATATTGTACC
+AAATAAAGAAAGCTTAGAATACCAAAAAAGCGCAAAATTGCGCTTTTTTTATGATATTTA
+AATAACAAAATCTAATACTATCCAACCTAGAACTGTCAAAATAATTAAACCTGCAAATTC
+TAGAACTGAAAATACCCAGAAAAACTTTCGTTTTGAAACAGTTCCGTTTTCAACAAAACT
+CTTGAAAACAAGCATATTGGCCATTGAACCAACGATTGAACCGAATCCTCCGATATTTGA
+GCCAAGGAATAAGGCTTCCGCAAAGTTAGTAAATTTACCAATTAAAATTGTTGAAGGAAC
+GTTAGAAATGAATTGACTGGAAATAATAGAAGTCAAGAATACAGAATGTTCGGAGAACAT
+TGTCTTAGAAATTAAAGTAACAATAAATGGAATTTGCTGGATATCGCTAATAAAAATGAA
+AAAGCATGTGAAAGTTAGAAGTAGAGCATAATCCACATGTAACATAATAGAAGGATTAAT
+AATAAGAGCAAGGATCACTGCAACAATTGCAGGAACATATGCAGGTACAATATTGAAAAC
+GCCAAAGAAGAAGAAAATTGAAACAGCAATCGTTAAAAGCATTGGTCGAATGCTGATTCT
+AATGTCTTCTAAAGGCACAGTAGGGATTGGCTTATCTTTAACAAAAAAGATAAACACTAA
+AACAATAATTAAACTAACTAGTAATAATGGAATTGACCAACTAAAAAACTTAATTGGTGA
+AACATTATAACGGTTAACAACAAAGATGTTATGAGGATTCCCCCATGGCGTAAAAGCAGC
+GCCAATATTTGCGCCCATCCCAATTAAGGTGACAGGCAATATCTCAGGTAAGTGATGGCG
+TCTAGCAATCGTTAAATATAACGGTATAAGAGTTAAAACAGTTATATCATTAGTTAAAAA
+CATCGCAGAGATAATTGACAAAATTGTGAAGATTGCAGTTAATCTTCGAGTACTCCTAGC
+GCTTGCAGTTAGTTTATAGGCCAAGACATCCAAAACATGTAAGTAAGAAAAAATTTGGAT
+GATTGTAAGCATTGCTAGAATTGAGTAAAGTGTATGGAAGTTAATATCTTCAATACGCGG
+TCTTGCGAAGAATAAGCTTATGATCGTTATGACAACCGTAATTTGTAAAATACGGTCTTT
+AGCAATATTTTTGATGACGGTCATTAAGGTCCCCTCTTAAAATTAATTCAACACTACTAT
+TTTGAACTCTTTACGGCAAGTTCGCAACGCTTTTTTCGCATTAGTCCTTCCTATTAGTAA
+GATTTTGAGCATTTTATTAGGAAAAACGGTAATTAACCTGCTATATTTAAGTTAGTAAAA
+GAGGACGGAGGAAAATAAATATGGTTGATTCCAAGAATCTTGAATTAAAAATTAAAGATA
+GTGCTAAAGAAGTTTTAGAAAAGAAAATTAAGCCAGGACAAGTCGTTTTGCTGGCTTTAA
+ATGATGGTTCAAATGGCTATTCTAAATTAGGTGGAACTTGTACAATCGGTGCTAATTTTC
+AACTAGTGTTGCTAGATCATAAGGATCCAGAATTTTCAATTAAGGTTAACAACAACATGG
+GTTTAGATATGTATACATCTGATAAAGAATTAGCCTTTTTAGACGATGGTTTAGTTCTTA
+ATGCTCGTAATGCTACTCTATCCTTATCTTCTAATGAAGGAATCATCGATGGCGGAGTTA
+CTATTTCTGAATTCAAAGGAGAAAAACTTTCTGCTGATGAGATGAAAAAATTAGGTGGAA
+AGATCTGCTAGGTATTGAAGTGACGTGCTTCTTCGTGGTATGATAATAAAAGATTTTCGA
+AAATTTTATTTGAGAGGAAGTATAGATCTATGCGTAAAGGTGAAAACTACAACACTGGTG
+TTACACCAAACTTAAGACCTAAGAACAAGAAGAACTCTAAGGCTCGTGTTAAGAGAGCTG
+CTGAAGTGGTTGCTTTCTTAAACAAAGCTGCTAAAGATGAAAACAAGTAATTAAATTTAC
+TGCATAAGATAAAGAGAGACGCTGGTTAGCGTCTCTCTTTTTTTGCATGTAAAAGTTATA
+TAAATTCTAATTTATTTAATAACATTTTGTTGTAAATGAATTTATATTATTATATAAAAA
+GCCTTATAAAATATGAAAAATTGAACATAGGATAGAATTTTAGATGAATAACATTTCGAG
+AAAAGGGCTAGAAGTAAAGGCAGTTTTTGCCCTTGTTTTACCCTCTCTTTTTTTAGGACT
+AGCAAGTAACTTTTCCCGCAATATTTTTTTAGGAGTTATGCTGCTCTTAATTTTGGGAGC
+AGTCGTCGGCTTGAGCATACCAACTATTGTTAGTACCTGGCTTATTTTGATTTTGACTGT
+ACTAGGGATTAGCTCTCTAACTCTTGGATATGCGGCGATAGATTTTTATGGAAAGACCCT
+GCTGCTTATTTCTTTTCCCTTAGAAACATATTTAACTAGTCAAATTAAAGAGTGCGTTTT
+TAGATGGCAAATATTTAAGAAAAATCAGTCTAGTGCTTACCGTTATCTTAAGCACTACGA
+TCAAAATGTAAAATTACAAACGACATATAATGCAGAGAAGTTATATAAAAAGATTAAGAG
+AATTTTAACGGAGAAAAATTATTTACCATTGTGGTGTGATTTTACGATTATTGATTGGGA
+ACATGATCAGCAGTTTGCGCAATTTAATTTAGAAGATCATGACAAAATTTTGCAGCAAAT
+AGCAAGAGTACTTAAAACAAGTAGATTAGTTGATGAAAATTTATATTACCTGGGAAATGG
+TCAGTTTCTAATTATCTCTAATACGATCGCACCAGGTACATTAATGGTTTTAAATGATGA
+ACTAAAAGCTGAGTTAAAAAGGCTACAGTATGGGGAATATCAGCCTGCTTTTAAAATGGC
+AACGCAGCACATTACAGAACAAGATTTTCTTGAGTATCCTAATTTTAATGCAATTCTTAA
+ACGTCTAAAAAGAAAGCTTGAAACGGACTTAGTTGTTGAATATTTAAAGGGAGTAGAAGC
+ATGAGTAATTGGTTCTTTTTCTTGGTAATTTTGGTTACTTTAACATTTCTAGTGGCATTT
+TTTGCTATGTTTCGTAGCCTCTGGACTATTTATCATCAAACTGAGCATACAGTGCGTCAT
+TTAGGAAGAAAGCATAATGTTAAATGATTTTTTAGCTGTTTCAACTTTAGTTTCAATTTG
+GTTTTCGCTTTTAGCTTCGTTAGTTACTCTTTATGGTGCAACTCGTTTTTGGCTTAAGCA
+TAGTAAAAAAGTCATTTCAATTACGCCACTAAAGCATTACCCCGCAATTACGATTGTTGT
+TCCAGCACATAATGAAGAAGTGGTAATTGCAAATACCACTAAGGGAATTCTTAACTTGAA
+TTATCCTGCATCAAAGGTCGAGCTACTCTTATATGCCGATAATTGCCAAGATAAAACTGC
+AGCTGAAATGCGTAAGACGGTAGATTTACCTCAATATAAATACAGAAATGTACAAATAAT
+TGAACGGCGTGGCTCAGGCGGTAAAGCAGGTGTCTTAAACGATGCCTTAAAGATAGCGCA
+GGGAGAATATATTTGCGTTTATGATGCAGATGCATTGCCCGAGAAAAATGCTTTATATTT
+TTTAGTGAAAAAAGTTTTAGAGAATCCCCAACGATATATGGCAACTTTTGGCAGAAATAA
+AACACGGAATGCGAAGCAAAATTTTTTAACTAAATGCATTAACCAAGAAGTTATAGTGTC
+TCAAAGACTTCAACATGTAGGTGTTTGGAATTTATTTAAAATTGGGCGAATTCCAGGAAC
+CAATTTCATCATCAATACTGAATATGTAAAAAAGATTGGTGGTTGGCAAAGTGGCGCCTT
+GACTGAAGATACCGAAATTTCTTTTCGCATTATGGAAGATGGCTATTTGATTGCTCTAGC
+GTATAATTCAGAGGCTTTTGAACAGGAACCTGAGCATTTACGTGATTATTATTATCAACG
+ATTACGTTGGGCTAAAGGAAATTATCAAGTAGTGATGAATAACTTTAAACACTTATTTGA
+TACTAGTAACTGGCGTGTAAAGCTAGAGACTTTTTATTTAGCATGTACTTTCTTTTGGTT
+TAATTTAGCTGTTGTTCTTTCAGACATTATCTTTTTTGTGGATTTGGGATGTATAATTAC
+AAGATTTTTCAATCCAGAAATCCCAATTATCTTTGCAATGAATTCTAATATTCTCTTAAT
+GCAGCTACTATTAATTAACTGGCTATTAATGATCTTGCTCTATGTAATTCAAATAAATCT
+CGCTTTAGCTACTCAATATGGTCAAGCAACTAGTGATCAAATCTGGCTAGCTTTAGTGTC
+ATATTTTACTTATTCGCAACTCTTCATTGCTATTTCTCTGCAAGCAGTCTGCTCAGTAAT
+TGGAGATAAGGTGTTTAAACGAGATGGTACTAAGTGGGTGAAAACCAAAAGATTCGCAGA
+TTAGGAATAAGAGATGAAAGTAAAGAATTTAATACTGATTTTAGGAACTATCATTGCTTA
+TTTAGGAATCATCGCCTATGTGAGGATGAGCAATGATCGAACGCTAGAAGAGCGATGTTA
+TCATTCGTGGCGTGAAGATTATATAAAAAATAAAAATCAAAATGAGCAATATGTGAATGC
+AGCAGGAAGAAATAATCCTTCATTTGCCTTATCTGAAGCACAAGGTTATGGAATGTTACT
+GGCTGCTAAAGCGGGAGAGAAACATTTAGGAAGTCGGATTGATTTTCAAAAACTAGATAA
+TTATTACCTGGCTCATCGCTTAACAAATTCAAATTTGATGAGCTGGAAACAGAAAGATAG
+AAAAAATATTTGGCGTGATAATCCTGTGAGTGCAAGTGATGGTGACATAATAATTGCGCA
+AGCTTTGCTGCATGCTGATAGAGTTTGGCCAGGACATGGTTATAAGTCACAAGCTGTTAA
+CTTAATTAATGATATTAAAAGGCTTGAAATCAATCAGAAAGCTAAAATGGTAACTGTCGG
+AAACTGGGCTAATAAAGATTCACGCTTTTATAATGTACTGAGAACATCAGATGTAATGCC
+AAAAGCGTTTGAAGAATTTTATCAAGTAACTGGGGATCAAGCTTGGCTAACAATTAAAAG
+AAAAATGCTTAACTATTTGCAAAAGTTAAGCAAGAAGTACAATACTGGTTTAGTTCCTGA
+TTTTGCCTGGATTTCTAATAATTATGTTAGGCCCGCACAAGCTAATGAAGTGGCGATTAA
+TGATGATGGTCACTACAGTGCAAATGCTTGCCGAGTTCCAATGTTGTTAGCTGAAAGCAA
+TGATAAAGAAGCAGCTCAAGTAGTAAAGAAGATGCTAAAATTTTTTAAGAAAAAAGGGAC
+TTCAGCTGGTTTTACCTTAAAAGGTGAAAAATTACATCATTATCAATCAGCGAGCTTTAG
+TGCGCCAATCTTTGTAGCGGCTAGTAAGTATCGTAATCAGGGTTATGATACTTTGATTGA
+ACAAGAAAAATATATCTTTTCAAGACCACTTCCGAAAGATAACTATTACGATGCTACTTT
+AACGGTTTTAGCTGCTTTAAATACAAATGAGTTGACGGGATTAGAAAAATAGAGAAAGAT
+TAAGTTGTTGAATCTTTCTCTATTTTTGATTTGCAAGAGTAGAACGGTTTTGCTATGATA
+GTAGAAATTTTAGACATCTTTATATTTCTGGAAGGGGTAAGTTTTTATGGGATTAAATGC
+ATATATTCAAGGTTTTAATAGTTTAGAGTCAATCGATCGTGCACCAGGTTATTTTAAATA
+TCAGCATCATTCTGTCGCTGATCATAGTTTTAGAACAGCTGAACTTGCTCAAATGATGGG
+AGATATTGAAGAAGTTGTTGGTAAACAAAAAATAAATTGGAAAGCCCTCTATGAAAAGAG
+TCTTAATCATGATTATACCGAGCGTTTTATTGGTGACATTAAGACTCCAGTTAAATATGC
+AACTCCACAATTGCGGAAGATGATTGGAGACGTTGAAGAAACAATGACTGCCAAATTTAT
+TAAGGACGAAATTCCAAAAGAATTTCAAAAAATTTATACTAAGCGTTTGTCTGAAGGGAA
+AGATGATACTTTAGAAGGTAAAATCTTATCTATTTGTGATAAGTTAGATTTACTTTATGA
+AGCTTATGGTGAAATTGAATTAGGAAATCCAAATCCAGTTTTCATGCAAATGTTTAAAGA
+AAGCCTTGAAACGATTAAAAAATTTGACGACTTAACTTGCGTTCAATACTTTATTAAGAA
+GATTTTGCCAGACTTATTTAAAGGTGACTTTGCTGGTAAAGATAAGATGCAAAGAATTGC
+TTTTAGTATTTTACTAATGGGGGAAGAATAGTTTGAAATTTCAGTGCGCATCCTGTGGGT
+TGCGACTTGACAGCCTTCATTTTAAGCAAGAAGGATTAATGAATCCCAAGTTAACAAGTA
+TTTGTGATATTTGCCTAACACGCAATCTAAATGCAGAAGATTATGAAAATCCAGTAATTG
+AGAATATTTCCCAGGTAATGCTCTATGGCTTTGTAGGAAAGAAAAATACGGGTAAGCTTA
+ATCTAGAGTCTTTAAATCAATATCTTGTAGGAAGCGATCATAGACGCCAATATGAATCTT
+TTATTCAGGATTATGATGGTAATGAAGTAGCTCTCCAGCAATTGTCACGATCTGAATTTA
+ATCAGGCAATTATTAAGAGCGAAGATAAAGAAATAAATTATATTCCTAATAGCAATGTTG
+ATTTTGCGGTTAATATGAAAAACATGGGAATTGAAGTTGACTTTTCTTTAAATGAAGTCG
+ATTTTGTTGACCGTGAAAGAATTCGTCATAAATATAATTATCGCTGCCAATATTGCGGTA
+GACGCGGGACGAGCGTAGATCACAAAGATCCAGTTTCTTTATCGCATGATAATTCTTTTG
+ATAATCTGATTTTGTCATGTAGCGAGTGTAATCGAATTAAATCTAATATGCCTTATAATT
+TGTTTACTAAGCTGAATAATCAACTTACTGTTGTAAATAGAAAATTGGTTAAGTACGAAG
+ATACTCTTGCTAATTTAAAAGAAGAATTTCAGCAGGCAAAACGTGATTTGGCTGGACAAG
+TTCATTTAAAAGGGGTAGTTAATGACCCTGAATTAAATGCGATGAGAAAGCAAAATAAAA
+AGCTTCAGGATGCAATTGATAGTTTGCAGAGCGATTATGATGCTTTAAGGAAATTGCGTA
+AGACATATTTTGAAACTGGTTGGAAACTAGCACAAGAAAAAGAAAATAGTGAGATTATAT
+AGTAAAAAAATGCATTGGACATAAAAATCCAATGCATTTTTTGCTATCTTAAAGTTCATT
+ACTTCTAAAGTTACGTAAGAATTTCTTAGTCTTCTCTTCTTGAGGATCATTAAAGATCTC
+TTGTGGTGTACCTTGTTCAGTGATAACTCCATCACTCATAAAGATAACTTGATCAGAAAC
+GTCACGAGCAAATCCCATTTCGTGAGTAACAATGACCATTGTTAAGCCAGTTTTAGCTAG
+TAACTGCATAGTATTAAGTACTTCACCAACCATTTCAGGATCTAGCGCACTAGTTGGTTC
+ATCGAAAAGTAAGATTTCAGGATCCATCGAAATTGCCCGCGCAATAGCTACACGCTGCTG
+TTGTCCACCAGATAATTGTTGAGGCTTTGCAGTTAAGAAAGGTTCCATGCCAACTTTCTT
+TAAGTTCTCAATTGCAACTTTTTTGGCTTCTTCTTTAGAGCGTCCAAGAACCATTTCTTG
+ACCAATCATACAGTTTTGAAGCACGTTTTTATTATTAAATAAATTAAATTGCTGGAACAC
+CATACCAACCTTTGATCGGAATTTATTGCGATCAAAATGAGAATCTAAAATATTGTTACC
+ATGGAATAAGATCTTACCATTGCTTGGTTCTTCAAGAAGGTTAATACATCTAAGCATGGT
+CGATTTACCACCACCAGATGGCCCAATAATGGTCATTACTTCACCTTTATTAATATCAAA
+AGAAATATCTTTTAATACTGTGTGGTCGCCGTATTTCTTTTGTAAATGTTGTACTTGTAA
+AATGTTTTCTTCGTTATTATTGTTCATGTTCAAATCCAGTCTCCTTTGGATCTTCTACTT
+GTAATTGATTAGCCATTAAGTTGTAGTTCTTTGGACCTTCAAGCTTCTTTTCAATGAAAT
+TAAAGATTCTAGTAATTGAGAATGTCAAAATTAAGTAGATCATTGAAATAATGAAGTAAG
+TTTGGAAGAATTGGAAGGTTTGACTGGCAACAGTTGTACCAACAAAGAACAATTCTGATA
+CAGAGATAATACTTAATACTGAAGTATCCTTAATGTTAACAATAAATTCGTTAGTAATTG
+ATGGCAAACAGTTTCTAATTGCTTGTGGTAAAATGATATGCCACATTTGTTGTGAGTGAG
+TCATACCGATAGCAGAAGCTGCTTCAAATTGACCTTTAGGGGTAGCGTTAATACCACCAC
+GAATAACCTCGGCTAAGTAAGCACCAGTATTAATTGAAACAATTACTAGAGCAGCTACTG
+TACGGTTTAAGTTAAGGTGCCATAATTGGGCAATTCCGTAGTAGATAACAGCTGCTTGAA
+CCATCATAGGAGTTCCACGGAACACTTCAATATAAACTGCTAAAATCCAATCAACAATCT
+TTAAGCCCCACTTCTTACCAGTAGACTTAGGAGTTGGGATAGTTCTAACAATACCCACAA
+GTAAACCAATGAAGAAACCAACAATAGTACCAACTAAAGCTAAAAGAAGAGTCATTCCAA
+CACCGCCAAGGATCATTGAACCATAGCGATGCATAATTGACATAAACCAGTTTTCTTTCT
+TGCTGCCACCTGCTTGAGGCTGTTCCTTTACAGCATCAGCCATTAATTGGTCGCGCTTTT
+TCTTAGAAATACCATTTAAAATGCTATTAACTTGGTTAAGTAATTCAGTGTTGCCTTTCT
+TAACACCAATTGATGTAATTGAATCATCGTGGTCAACTTTGAATCCTTGCATCTTGTTTA
+AGTTAACGGCAACGATGTTAGGGTTAACTGCCTTGTAACTTTGGTATTCAATATCTTCTG
+CTACATAACCATCAATAGTACCTGATTGTAAGCTTTGACGCATTGCAGAAAAGCTTCTCA
+TTGCTGGTTCACGCTTAGCGCCATGTAATTGCTTAATTAGATCATAGTGCAATGTACCTT
+GTTGAGCAGTTAATTTTGCGCCTTTAAAATCATTTAAGCCTTTTGCTTGAGCAAATTTTC
+CAGTCTTGCTTGTAATAACTACGAAAGTACTCTTTCTGTATGGTACAGAGAAGTTGATTG
+CCTTTCTACGTTCAGCAGTAGGAGACATACCAGCAATAATTAAATCAATTTTGCCAGAAG
+TTAAAGCTGGTAATAGACCATCCCATTCGGTCTTTTCAACGACAACTTTACGATGAAGCT
+TTTTACCGATAATTTTTGCGATTTGTACATCATATCCATTTGCATATTGCTTAGATCCAT
+CAATTGGAACTGCACCATTTGCATCGGTTGTTTGAGTCCAATTGTATGGTGGGTAATTAG
+CTTCCATACCTATTTTTAGGGGTGCTTCTTTTTTAGCCGCTTCGGTTTGACTAGAATTAG
+AGCTAAAACCGATAACTAAACTTAAAATTAGGGCTAATAAAGCACTAAACCATCTTATTT
+TTGACTTCACTTTGAAATACCTCCAAAAATTATTTCAAATAAAGCCAATACAATAAAAGC
+GTAAATAAAAAGCCTCGCTGTTTACCAAAAACAACGAGGTTTGAAAATCATCAGTAATTA
+AACCAAATCATATAGCGCTCCCTGGGGACTACCAGGACAGTATGTAAGATATGCTCTCAC
+ATCCCAACAAGCTTAATTCGCGAAAGTAAGCTTGTTTCGGCGATAATCCTAAAAACTACT
+GTCAATGTATTCGCGTACTCAAGTAGATTTTGTGGTTATCGCAACCTCTATTGCATTGGG
+GATTTATTTAACTGATGAAAAGATTAAACGATTTTTAATATTTTGTCAAATAAATCCGTG
+ATTTTTTTTGACATCTTTTTTCTTAATATCTGAAACATAGGGATTACCAGCAACTATAAA
+TCTTAGCTTTTTCTTGGCCCATTTAGGATCTGACTGATTGATCCCAACTCTTGGAAGAGC
+AGTAATTTTTTCAATTTTTCGTTTATGATTAATATCAATATCAAAAGGAGAATCTTCTAA
+ACGAGCTAAGTCCCATTTTCTACTAGTAATTCCAAAAGCCTGCATCATCTTTCCAGGGCC
+ATTAGTTAAAAGTGGACCAGTTTTGCCGTTGCGATTTTTAATCATGGTATCAATTCCGGT
+CAGTGGGTCAATTGCCCTAATTAAAACTCCTTGTGGTTCACCTTCTGCTTGGCACGCAAC
+ATCAAAGAAGAAGTATTGTCTCTGAGAATAGATATACAAACTGCCACCAGGACGATATAA
+GCCTTCATTTGCCTGACTGCGTCTGCCACCATAAGAATGGGCAGCCCGGTCTTTTACACC
+AACATAGGCTTCTGCTTCAACTATTGTGCCTGATAAAAGTTCATTTCCATTGTTGAAAGA
+TAAAGTTCTACCCAACAGATCTTTACTAATTTCACTAGTAGACCGATTAGTAAAAAATTC
+TTCATAGTTCATATTACTACTTCTTTCTAAAAATGTTGTACACTCGTACTTGAAAGTAAA
+TATAAATTGTAGGGGGAATCAAAAGATGAATGAAATAAAAGTTGTTAGAATTTATGACCA
+TGAGCAACCCGCAGGTTATAGAATCTTAGTAGATCGCTTATGGCCTCGAGGAATGAGCAA
+GGTAAAAGCTCATTTAGATGAATGGGATAAGGAAATTGGGCCAACTAATGAATTAAGAAA
+ATGGTTTAATCATGAAGATGACAAGTTTCCTGAATTCAAGACTAAGTATATAGCGCAATT
+GAAAGCTAATCCAGTTACAACCGAGTTTGTTAAAAATGTAAAAGAAAAGCTAGCTCAAGA
+AGACGTTATCTTCTTATATGGTGCTAAAAATAAAAAGCACAACCAGGCAGTTGTGCTTAA
+AGATTTTATTGATAGTCAATTAGGTTAAGGCATTTTTTTGCCATGCAAGTTTTGTCGAAC
+GTAATGAAAAATAATTGTTAAAATAACTGTACCAAAAACGATGCCGGCAAAGATGGCATC
+GGGCAGTTTGAAGTTTAGCGGTGGCAATGAAACAAGTAGCTTAACTGCAATGATTGTGAT
+TAAAACATAGGCCATTGTTTGAAGTTCAGGAATAATTTCCATTAATTTGATAATAACTTC
+AGCAACTCCTCGCATGCATAGAATACCAATCATTCCGCCAACTAAGACGACAACTGGATT
+ATTTGACATGGCTAAGGCTGCTAAAACAGAGTCAATTGAAAAGACGATATCCATTGACTC
+AATTGAAATAACAGTTCTCCAAAATAATGAAAGATGGTGCTTTCTTGTCTTGGAGCTCTT
+TTTCTTATGGGCTTCTTTTTTTGCCGCTTCTTTCTTAGCAACTTGTGCAGGGTGGCGAAG
+ATCATAAAAATACTTATAAACTAAGTAAAGTAAATATAAACCGCCTAACAGTTTGATTTC
+CCAGAAATTAATTAGGTAAGTACCAATCCCAATTACAATAAAGCGAAATAGATAAGCCCC
+CCAAAGTCCGTAAACTAACGATTTCCTTTGCTCATCTTTAGTTGGTAAAACTTGCGTTTG
+TGCGGCTAAAACCACCGCATTATCAACTGATAGCAAACACTCCATTAAAATTAGAGTCAG
+AATCATCATCCAATCTTGTCCGCTAGTTAGGACATGAGCCCAGTTATTAGCGTCAAAAAA
+GGGTTGATAAAGTTTAATCAATTGCATTCAAATAGCCTTCTTCAAGTTTTATTAAGCGTT
+GCTATTCTTTCTCTCCCATTCTATAACTTCCAACCTTATCTGACGCTAAAATTACGCGAT
+GACTTGGAATAAAAATTAGGGATGGATTTAGGGCTACCGCATGTGCAACTGTTCGAACCG
+AAGTTGAGCCATTAATAGCAGAAGCTAAATCATTGTAAGAAATGGTTGTTCCATAAGGAA
+TATTTTCAATCATTTTAACAACTTGATTTTGAAATGGAGTACCAAAGCTTGAGTAGTCGA
+TAGGAACGGTAAAGGAGCGACGCGTGACTGCAAAATATTCTTTTAATTGTTGAACATAAG
+GAGCCAATTTTTTGGAATCTTGGACCAGAATGTGGTTAGGATAAAATCCTAAAATAGAAG
+ATTCAATATTACTATTCTTGGAACCGACGAATGCTAATCCCAAGTTACTAATGACTAATT
+CATAGGTCCATGGCTTAATTTCAACAAAATCGTAATAAAAAACTTTTGCTTGGGCAAGTG
+GCATTTAATCCTAACCTTTCTTTTAATTAATATATTAACTCCATCTTATATTGTACAACA
+AAAAATAACGAAACTGTCAAATTTTTTGTGTAAATAGAT
+>NODE_3_length_40000_cov_63.0619_ID_5
+CATATCCCCAAACTAATTCTAAAAGCTTATCTCTTGAAAAAACTTGTTTTGGTTTTTGAG
+CCATCGTGTAAAGTAAGTCAAATTCCTTTGGAGTTAAGCCTTCAACAATATTATCATCAA
+AGCGCACTTCTCTTCGATCTTTTGAAATCTTTAGATGCTTAGTAATTACATCATACTTTA
+CGCCATTAGAAGCATGCATATCTTTTTCTATACGACTTCTTCGATATAAAGCTTTAATGC
+GGGCAATTAGTGCTAATGGACTGAATGGTTTAGTAACATATTCATCTGCACCAATGCCCA
+AACCCAAAATTTGATCAGTTTCTGAGTCACGTGCAGTTAACATAATGATTGGTATTGAAA
+GAGAAATAGCCCTTATTTCTTTAGCTACTTCCATTCCATCCTTTCTAGGTAAGTTAAGAT
+CTAACGTTACAATGTCATAAGAATCTGGATGCGCTTTAAACATCTCAACAGCTTCTATAC
+CATCCTTAGCTATATCTACTTCCCATTGTTCTTTACTGAAGAACATCTTCATCATTTCTG
+CAACAGAATTGTCATCTTCAACCATTAATATCTTTAGCATTATTTATCCTTAAATCCTTT
+TACTCTAGTATGTTTAATTTTATCTGGTTCAATATAATCATGTGGTAATTCATGCCGGGC
+ACGTAAGAAAGCCTGCAATTTTTTCTCAGTTAAGATTATCGGAGCCAAAATAAACAAATA
+AAAAGTAAGCAACCAGATCAAGAAATAGCGATCCCAGTGTAAGAAATGAATTCCTAATCC
+CAATAGAAATTGAACTAAGCCAAAAATCATGAAATAATTTCGTGCAACTTTTTGCGCATA
+CTTGTAACTTGTTTCATTAACTGAAGCCAAATACGACATATATCCATAAACTTGATTCGG
+ATTAGGTGAAGGAGCGATCAGCCAAATGACTCCGATTACAAACATTATTACCCCGCAACC
+AATATATATCATTTGACCAACTCCATTCACTTAAATTTATTCTTTACCAGGAGCTGAAAT
+TACTAAACGTAAGTCACCGCTAAAACTAAAGTTCTTCATCTCATTAGGAATAATAAAATT
+AGTACCCAATTTGATATTATATTCTTTACCGTCAGCAATAAACTTACCTTTACCTTTAAT
+TACAGATACTAAAAGATAAGGATGATCATTTAGACTCCAATCAAAACTCCCATCAACATC
+GATCTGCCATAAATAAAAATGCGGTGACATTGGTGGTTGAGCTAAAGTAGTAATCTTTGC
+ATCTCCCAATGTTTCAGATGTAATTTTCAGCTTCGGATCTTTATGTGGTACTTGAATAGT
+ATCAAGAGATTGTTTAATATGCAACTCTCTCTTTTTACCAGTTTTCTTATCTACTCGATC
+CCAATCATACAATCTATAGGTTACATCACTTGATTGTTGTGTTTCAATAACCATAATTCC
+TTTAGTTAATGCGTGAACCGTTCCAGAAGGTACATATAAAAAGTCTCCTTCTTTCACTGG
+TACATAACGTAAAAGCTTCGACCACTTTCCATTTTTGATCCAATCTTCTAGTTCTTCTTT
+ACTAGTTGCATTGTGCCCATAGACAAGTTTAGCACCAGGTTCGGCATGAAGCACATACCA
+ACTTTCAGTTTTTCCAGAATCATTTTCATGAATTCTAGCGTATTCGTCATCTGGGTGTAC
+TTGAACAGACAAATTATCATTTGCATCTAAGAATTTAACTAATAGTGGAAATTCCTTAGC
+CTTGGGATTACCAAATAATTCTGGATGCTCTAAATATACTTCTCTTAACGTCTTTCCTTT
+TAATGGACCGGCATTAACTGTCGAAGCGTCATCTTTGTATCCAGATATTACCCAAGCTTC
+TCCAACTTTTCCATCTGGAATATCATATCCTAAAACTGTATTTAACTTACGTCCACCCCA
+AATTTTGGGTCTGAAATATGGTGTTAAAAATAATGGTTCCATAAAAAAATCACCTCAATA
+AAAGTATATATCTTTTTTAGATGATTTTGAAATCGATTTCAGCTATTTTTTTGAATATTT
+TTTTATTCCACTAATTAAACGTTTAATTCCATCCTCTACCATAGAAATTGGTGAAGCTAG
+ATTAAGCCGTAAAAATTTATTACCATTACCGCGATAAATACTACCAGGTGAAACAATTAG
+ACCAGTTTCTTTTCTAATATAATCAGCTAATTCTTGACTATTTGACGAAACTTTACTTAC
+ATCAAGCCACAACAAGTAAGTTGCTGGACCTGATACAATTTTTACATCTTCCAGATTATT
+AGTTATTTCTTTTTCAGCATAATTAAAATTACGATTAATTATCACTAACAATTCATGTAA
+CCAGCTAAAGCCTTCAGTATATGCAGCAATTGTTGCTGGAATAGCTAAAAGATTTGGCTC
+AGCCAATTCATCGCTGTTAAGACCTCGATTGACGATATAACGTAAATTTTCATCTGGAAT
+AATTACGGTTGCAGCATGAAGAGCAGCTACGTTAAAAGTCTTACTTGGAGAAACTAAACT
+AATTATATTATCCCTCAAAGCTTCAGAAACTGAAAATGCAGGGGTGTATTTAACGTTATC
+TCTGACCAAGTCTCCATGAATTTCATCTGATAGAAGAATTACGTGATATTTTTGACATAA
+AGATGCAATTCTCTCTACTTCCGTAGGTGTCCAAACTATCTTTACCAAAATAATCACCAT
+TAATTTCAGCATTTTTAATTTTGACGTCCTCACAAGTCCACATTGTTTCTTCTGCATTAG
+AAAAGAAAACATGATCTAATGAAATATGCTTACACCGTCTAAATAACTTAGGAGCTTGTA
+AATCTGAATTTTTAATTGAAATATTATTAGTATACCAAATACCGCTTCGCGACATTGTTT
+CAAAGGTACTGTCAGCAACTTTAATATTATTCGAATACCATAAAGGATATTTATATTTAA
+AAATAGTAGATTTTATTTCTAAACTTTGCGTTTCTTTTAATGGTGATTCTCCTTCACCAA
+AAGTAATATTCTCTAAAATTGTATCCGAAAGGCCATATAGCGGTCTTTCTCCTTCAAAAT
+ACTTTTCTTTAATTATTTGCATAGATTTCCTCTTTTATTAACTCTTTCAATATTTAGTCT
+AAATTATGAAAAATAAATGTCTAATATTTGCTAACTATAACGAAATATATTTTTATGCTA
+TAGATTAGTTTTGCACCAAGATTACTTTTCAAATTTATTATAGAAAAAATAAAATTTTGA
+GAAAATTTACAGTTTTTCATACTAGAATAAATTAAATTTATAGCAAAAAAAGGATGAGTT
+TCAAAGCTCATCCTTTTTAATCAATTTAGTTATTACGTTTACGCTTAGAAACACCAGCTA
+AGCCGATAACGCCAAGCATTGAACTTACAGCACCTACTATAGCTGCAACAATACCATTTT
+TAGCTCCAGCTTTTGGAAGTTCTGATTGAGTTGTCTTCTTAACTGAAGTTGTTGGAACTT
+CTGAAGTTGGTTTAGTTGGATTATGCGGAGTATCAGGAGTATTTGGTGTTGTTGGTGTAT
+TAGGTTTCTCTGGAGTAGTTGGAACATTTGGAATTGGAGTTACAGGTTGATGTGGCTTCA
+AGTTATATCCACCGATTAAGTCCCAATCAACTGGTTTGCCCCATTCACCAGGAAGAGCAG
+CACTATTTGGTGCATCTTTTTTAAGAACACCCATCATATCATCGTTTTCGCTAGTGTCAT
+CCCAAATCCAGTCACCTTGGTTAGTCATTTTAGCTAAAACAGTAGTAGTATTATCTGGAT
+TAATTTGTAACAAGAAACTTGGTGCCCAAGTTGCGTGCATACCCTTTCCAGCAACTTCAC
+CACGGTTAGTGATATAAGAAGTAATCAATAATTGATCATCTCTTCCTTCTACTGGAACTG
+CATAGTATGAGTAAGTTGCAGTACGCCAGTTTGCTGGAACAGAAGCAGTTAAAACTACTC
+CAGATTCATTTAATGGAACGTATCCATGAGTTAGGTTATCAGAAACGTAACCAATCATTG
+CAACGTTATCACCAACTGCTTTATTAGCAGCCATCCATGCATCGTCGTTACTTCCACGGT
+TTAATCTAGTAGCAGCAAATAAGTAATACTTGTTGCCCAAACGAACTACATCAGGACGTT
+CAATTTCATCACTTACCATTGGAGAACTAATAAGTGGTGTGTAGACCTTCTCAACACCAG
+GGTTCTTAGTATCATTGTTTAACTTAATAATACCGATTGCAGCATTAGACCATTTTGCTC
+TATCTTTAATATCAGAGTTAGACAAGATTTGGAAGAAATCACCTAAATTATCTTTGTTAG
+TGCCACCGTAATTTAACCATTGATAAATTTGGTCAGCACCTTGATAATTCTCTGTACCAG
+TACTTGCTTCAAAAACGATGTGGTCATTATCGACGTGTGCAATAGAAATCTTGTCTTGAT
+CCTTTTCAAGATTTAAGTAGACAGTTGCACTTGCAATCTTTTGGTGGTTAGTGTTGTTAT
+CACTTGTATCAACCTTAGTATAGTAAAGTTGGATTGAACCATCTTTATTTAAAGTTGCTG
+AGCCAGACCATTGTTGAATAACTGGAGTACCTAAGCCAAAAATAGGACCAGCATTCTTCC
+AATTATTAAAGTTATTGTCACCGTACTTGTTGTAAAGAAGATAAATATGATTGTCATTAG
+TATTTGGAACTCCCATCATTCCAACTACTAATTGATAACCATTCCAGTTAGAAACATAAC
+CAGTTTTGCGTCTTGAACTGGCCATGAATCCCAAATTTCTAAGTCTTCTACTTTTCCTGT
+TTGGGCATCCATAGTTTTTGCTGCAGGCATGTTCTTAATTTTACTTGCATTAAAGAAAGG
+AATAGCGTAACGAGCATCTTGTTCAATTAAAGTTTTAGCAATTTTCTTAAAGTCACTGTA
+AGTTAATTGAGTACCGCTCTTTGCTTCTTTAGAAAAGTTAATCTTATTTAATTCATTAAT
+TTGATCATTGGTTAATTTACTGGTATCTACATCAGATTCTTTAACAATATCTTTAATTTG
+ACCCTTTAATTCAGCTTTGTTATCGTTTGATGCTGTTTTTGTTGAAGTTTCGTTAGCTTT
+TTCTTCAGTATTTGTCTTAAATGAAGTAGCTGCTTTTTCATCTTGTTTTACTGCATCGTT
+CTTTTTAACATCAGCAGAAGAATTAACAGGTGTCTTCTCAGTACCATCTACTGTTTCTTT
+AGTAGTTGTTGTAGAGGTGGTAGCAGCTTTAACATTATTTACTGGTGAAGTATTAACAGC
+ATCTGCTTTAACTTCTTTAGTTGCTGCTGAAGTCACAGTAGTAGCTTTTTCTGCTTTAGT
+ATCAACACTCTTTTCTGAGCTTGAATTTACTTGATTATTATTTTTATTATTTGCTGAAGT
+AGTAGTACTTACTGCTACAGTTTTGTTTTCATTAACGTTGTCTGCATTAGTAGTAGCAGC
+ATTTACAGTGGAAGCACTTAATACAATTGCTGCTGTAGACAAGGTTCCCATTAATAAAGA
+TTTTCCGCTTAAAGACATCTTCTTATGATTTTTATTTTCCAACATCTTTTCTCCTCCTAC
+ATGCTAAGCGTTTAACATTTCATCTTACAGACTATCACCTTTTGTTATAAAAATAAATAT
+TATTTTAAAAAAATTGTATAGATTTGGCAAAATTTACTGTTTTTGTATTCAATTGCCACT
+TGTCAATCGTTTATCACATTAATACTAAAAAAGCCACACCAGATAATTACTCTAGTGTGG
+CTTTTCCAACTATTTATGGAGATGAGGGGGTTAGAAATTTACCCTTGCAAGTCCTTTAAT
+ATCAATGCTTTTAGCTATTTTAACTTTTACGTGAAGCCCAATATGAAGCCTTAAGATTGC
+ATGTAATTAGCAAAGTTGGTGGCTGTTTCTTTGGCCTTATCCTTAGTTACATGAGTATAT
+ATATTCATAGTTGTAGTAATATCTGAATGCCCTAGCCTGTTCTTAACATCTTTCATAGAT
+ACACCAGCATCAAATAATAAGGAAGCGTGTGTATGCCTGAACCCGTGAACCTTAATCCGT
+CTTAATTCATACTTATCACAAATTGCAATATTCCAACGACGTGGCTTAGATAATGCTGTA
+TGTTCTCCCTTAGTATTAGCAAAAACTAAATTACTATCATCTAAAAAGTTTAGTCCAAGT
+TTAAACATTTCTTTCTGTTGTTCTGTTCTCCACTCTTTCAAGTAATTCATTGTTTCGCTA
+TCCATATCTAGCACCCTTACACTATTAGCCGTTTTTCCTGGTGTTATGATTAGTCGATTA
+TTTTCACCCGATGATAAAGACTTATCTATATTAATGGTATTATTTTTAAAATCAATATCA
+GCCCATGTAAGAGCTAGACACTCACCGCGTCGCATCCCTGAATAGGCAAGCAAGCGAAAG
+AACATAAAATATTTAAAATTATATTCTTTGGCATCTTTCAAAAAGGCTTTTAATTCTTCC
+TTACTATAGTAATCAGTAAACTTTTTATTATCCCTTTCAATTTTTGGTATTCTTACCTTT
+TGCATTGGATTTCTTTTAACTAGCTCCATATCCATTCCATACTTAAGTAATTTTGAAGTA
+TAGAATTTGAACCGTTTAAAAGTCTTAGGTGCTTGCTTAGACCATTCATTTACTACCTTT
+TGACATTCAGCAACGGTTAATTTATCCACGTAGATATTACCTAAATCTTTTAAAATATGG
+TTCTTGAATATCTTTTCAGTGGTCACGAAAGTACTTTCTTCTACTTCCATGCGATACTGT
+TTAACCCACATATCATGCAAATCTTTAACCCGTAGCTTTTTTTGTTCAACTGGTTTATAC
+TCACCTTTAAGAACTTTCAATTTATAATTCATAAAACACTCTAAGGCTTTATCTCGACTG
+GTAAAGCCTTGTTTTTTTATCTGGATTGTATGCCCTGTTTTTTCATCCTTACCAGCATAA
+ATTAGAAACTTATATCTTTTCTTACCACTTGGTGTGGTATATTCCTTAATTTCATCATTC
+ATGTTAAATTTACCTTTCACTAATAAAAGGCGTACTGATTGGCTGATATTAAACATTTAA
+CAAAACTGTGGAAGTTATAGGAATAATTCAAATGATTAGCTATTAGTAAAGATGATTTAA
+ATGGTCTTAGAATTGCAATCTCAGCATTAACAAGGGAACTCATAAGTTACCATGTACATT
+TACACTTTAAGGTGTATTTGTAACTACACGTTGATAGCCTGTACTTTTAGGTACTCCCTA
+CCAGCATATGTAAAAGCATGGAGGGATGTCCGTAACTGTAGTTACACTCATAGATTATAC
+ATATGCAGTTACAACTGCGGTTGTTAATTCCTAAAGGGATGCTAGCAAGCCAAATTATTA
+TTTAACCACCACCCTGATTCAGGTTACTGGTTTGAGGGATGAACTAAGCGCTCAGCCCCT
+GCACTACCGAACTAGTACCGCAGATTAGGGATGCTAGTTAAACACGTCCACAGGGAGTGT
+TATATATATTTTTGATTTATTGCAATTTGTCCTATTTCATTTTTAGCATTAGTTAACGCA
+TCAATTATTTTATTATATGCTTGCTCATCCATATCCTTACGAACTTTAAATGACTGCACT
+TTTAAACCGTTTTTCTCTTCTGGTGGCTCTAAAAAAGCTCTATTAACATTACCTATTAAA
+CGCGTTAGCTGAAACACTATTTCTTTTTGTACTCCCTGCGTAGTCGAATAAGAAGCACCA
+TCTAAACTTTTAACTGCTTGGTCTATTTGATGCTGAACATCGCTAGAAGCGTCTAATCTA
+TCGGTATCTATTAGCCTTTTGATTTCATCTTTTATTTGTTTAACTGAGTAGCCCGTGTTT
+TTAGCCCACTCATCCCAACCGTTAATATCATTAGATAAACCCATCAAATAGGAAGTCGGA
+ACTTGAAAGAACATTGCTAGCTTATCCCAAGTTTCTATTTTTGGCTCTCGCTTTCCACGT
+TCATATTGGCTAATAGTTACATATGACATATTTACTTGTTCACTCATATCTCTTAATGAC
+AAGCCCTTTGCTTGTCTTAATTTTTTAATTCTATTCATGCTTTCACTTCCATTCTTTCAC
+TAATCTTAACATAATGTATTCGTTTTGAAAAAATATTTGCGTTTTCATTTTGAATACTTT
+ATCATGTATTCATAAAGAATACAAAAAAGAAGGCGAAAATATGCAACTAACAGAAAACCA
+AGTAACAGCGATTAAGCGAAAACGTGGCGAACTTGACATGTCTATTACAGTTTTAGCCAA
+TACTACCAAGGTTAGTAAACGTACTTTAATAGATATTTTCAAACACAACCACAGAAATGT
+GACTAAAAACACGTTTAAGAAGCTAAATGATTGGCTGATTGATGAATATGAAAGGAAGCA
+ATAGCATGAAGCGAATTTATAGAGCATTCAAAGACTGGCTATATTTACCAGATAGCAATG
+AAGCCGAATTATACAACTTGCTACTTTTCGGCGTTCTATTCTTAAGTGCAATTGTAGCAA
+TCGTAAGTTTTACCAGAACACTTGCAATGTTTTTGGCATTGATTAGATAAGAATGGAGTT
+TTAGAAATGATGAAGAAGATGAATATTGTTTATCTACCACTGGTAGAACAAGCTTATCAG
+ATGATGAAAAAGCTTAATAAGAACGTATCTAAGCAAGAGATTTACAAGAAACTAATTGAA
+ACTAATATGATTGACCAGCAAGGTAATCCTACCAAGTGGGCGCTTGATAATGGGCTAGTT
+AGTGAATTTAACACAATTGAGGAAGCAAGAAATAAGCTTAATCAAATAAGCCCACAAAAA
+ATAGAAGACCAAGTGGACGCAGATATAAACAACGTATTTAGTCGCGTGCCAGTTAGTGCC
+TTTAGATGGAAGAATGAACACGATGGATATGCAATTGATAGTGCTGAACTTAAAAAGGCT
+ATTCTATCAGCATTAAAAGATGGTAGCTTATCCCCTATCGGTCGTAAGCACTGGCTAGAA
+GTATTAGCAGATATAAATTCACAGGAGAATTAAGAACAATGAAATATATTGAAGTTAAAA
+CCTTACCTATTAATGAAGATGAAGTAATCACATTAGCAATGAATGCAAACAATCTTACCG
+CTGGACTTGACTACCTTGAAAGCATGGCTTTAAACCTAGAGGGCAAAAACCAGCAAGAAA
+TAGAACAACTATCAGGATTAATAGCAGGTATGAAAGAATTATCAGCAAAGAACGCTAGAA
+TTTTAGCAAATATCAATCTTTAGGAGGTTACACAATGGATATTAAGCTAGACGCATCCCA
+AGAACAGGATTTAAGCAATCACATTATTAATTTAGTGAAAGACAGCGTAAAACAAGCAGT
+AAACAATGAAAGCAAGCCCTATTTAAATCGTAAAGAGATAGCTAAGTATTTTGGAGTTGC
+TGACAGTACAATAAGTTACTGGGCTACTTTAGGGATGCCTGTTGCAGTTATTGATGGACG
+CAAGTTATACGGTAAGCAAAGTATAACTAACTGGCTTAAGAGCAAAGAAAAAGCCGTGAA
+AAGCTGAGACAATTCACGACATAAAAAATAAAAACACAATTAAATATTAACACATATAAG
+TGTACTGGTTGGCTGATATTAAATATTTAATATTAAAAAAAGAAAAATGGAGGTTAAAAA
+TGAACAGCAATTCAGACTGGGCTCTTAACTATGCTAAACAGGGCTTTTCTGTCGTCCCTA
+CTAACCCAAGTAATGTAAAAATACCCGCGATAGAACACGCAGGAAAACCACCGCTAACTC
+AGGAAGAAATAAAACAGCTATGGACTGAAGAACCTAATTATGGCATTGCTCTAAAAATGA
+CTAATATTTTTAGCATTGACGTAGATACTCCACAGCATGCAGGAACAACTAAAATAGACG
+GCTTTAAGTCGTTAAAAGAGTGCATCCCGTCAGAATGGTTACCAGATACGTTAAACGCAT
+TTACCCCAAGCGGTGGGATGCACTTTTATTATATGAAAGTAAACGGCTTGCCTAATAAAT
+CAGGTGCAGCAATCATCCCTGGCGTAGACGTTCAAGCATCCCCTAATAGTATCTCTGTAG
+TACCACCAACTAAGCGCCAAGATGGAATTTATGAATGGAATCTAGTACCTGGGTCTAAAA
+ATCCCGTTGCTATTCCACCTAGAGAATTAATTGATTTTATTCAAGAGAAAACAAACCAAA
+ACGCATCAAAGCCTATTCTTTTTAAAACATTCAAAGCTAAAAATTACGCAGGCAAGTTAT
+TAGACGCTTTATGCTTTCAACAAGTCAAGGGACAACGTAATAGCTATTTAACTTCATTAA
+TTGGCAAAATGCTATTCTGTGGTGCTGAAGAAGAAAACTGCTACACCCTTGCAATGTTTG
+CCAATAGTCAATTTCAAGAACCATTACCAGAAAAAGAAGTTACTTCCATTTTTAACAGCA
+TATTAAGGAAGGAACTAGCTAATGAAAAATAAAAAAGTAAAAATGAATAAAGAAACAAAA
+GAGCTAATTAATTCTCACAAGAAACAAAAAGAAAAAGCGCCTAAATTGCCAGCTTGGTGT
+TATGTAGATGACAATGGCAATATAAAGGTCAATATTGGATCACTCGGCGAATTAATACAG
+AAAGAACGCAATTACTTATTCATTATTAATAAGGATAAGGAAACACTTTACGAATATAAT
+TATAAGCTTGGTTATTGGTTACCTATCTCTAAAGGATCAATTTCAAAAGCTATTCATGAT
+AAATTAACGTCGGTTGGTAAATGGACGTCACAAAATCAAAGAAAAACCTATGAATTTATA
+AATAGTGGTATTCCAAGAAAACAGTTCCAAGATACAATCGGACACTCGCCAGAAATGGCA
+TTTAATTTTCTTAACGGCGTTTACAACTGGTCAACGGGCAAATTAGAACCCCATAATAAA
+AAATATTACTTTGAGGGATGCACCAGCTACCCACTAGACATGGCAAACAATCAAACTTCT
+GAAACTAATAAATATTTTAAGTTGCTTTTAGGCGAAAATGCTAAAACCATGATGGAATTT
+ATTGGTTACTCATTTTACCCAAGTTATGAACCTATTCAATGCATCGTGATATTGAAGAAT
+GAAGGTGGAGACGGTAAAACTTGGTTTACAAACCATGTTATAAATAAAATGCTTGGAATA
+AATAATGTTTCTAATATTAGTTTAAATCAATTAGCGGACGTAAAAAATAACAAATTCAAA
+CCAGCGGAACTATTTCACAAATATGTAAATGTTTCCAGCGAATTGAGTGAAAGCGAAAGC
+TCATTATTACCTACTGACTCTTTAAAAAAGTTATCTGGTAATGACTATATAAATGTAGAT
+AATAAAGGACAACGTGACACACGCTTTCAAAATTACGCAAAGTTATTAATTATAACTAAC
+ACCCTTGTTCATTTTAGAGATGATAGTGATGGCTTTAGTCGTCGTGTTTATATTATGCCA
+GCTCATAAAATACCAGACTTTGAAAACACTATAGATGTTAGGAAAATGGAGGCAGAACGT
+GGAGCATTTGCGTATAAGTGCATCGAATTAGCTAAAGACGCAATGAAGCGCAAGCCTGTT
+AAAGGGAAAAGATACCTTACTAAAACCAACAGTATTAGCCGACTAGTAAACAACTGGATG
+CTAGACAATGACCCAGTGCAACAGTTTATTAATGATTGCGTTACCAAAGCACAAGGTAAA
+AGAGAAAAAGCGCTAGATGTAATTCAAGCTTGGAAAAATTGGTGTAGTGATAACGATTAT
+AAGCCGTTAGGCAAAACCAACTTTAAAAATAAAATGATTAAAAAGGGGTTTAATTATCAT
+GAAGAGAGAAAACGCGGTTCAGATGGCAAGCAACTACCGAGAAAGTATTATTTTACTAAT
+ATGACGCTTAACGAAAATGCTAACCCAGAGGGAAAAATAAACCCAGTTACTAATAACTAT
+GACTTTAATAAATAGAAAAAAACTGAAAAATTGGATTTATGCCACTTTTTAAAATCGGGT
+TGAGCCCTAGGGGCTGTAGTAATATGCCACTTATCCACTTTTTTTATTAATAAAAATTAA
+AAATATAAATATATATAATACACATAATATATATTTATTACGTAAAAATATATTACACAG
+AAACCCAATGGAAAGAAAAAAAGTGGCTTTTCAGCGCATCCCTTGTGGCTCTAAGCATGA
+ATCCACTTTTAAAAACTGGATCAAACTGGAACATAACCACTTTTTGCAATTAATTTAAGG
+AATTTACAGAATGAAACAAGATAGATTAAAATACGAGCTTAAAAAATACCTAAATAGTAA
+ACTGACCTACCCACTACACACTGTGGAAGATATTAGCATAGAAAGAATATTAAAGGTTTA
+TGGCAGCGAAAAGCCTAGCGGTTATGTAATTCAACTAATAATAACTGGGCAAGTAGGTAC
+AATACGAAAGGATAAATAGAATGGTAGACAAAAATCTTGAACATACCGTGTTCTTTCACA
+GCATGGACAGCTTGAACGAATGGCAAAGAAAATACTACAAAAAGATAATTATTACTGAAC
+GCATGGAGACAGCTAATAACGATTACTTAATTACTTTCTTTTTAAATCGGAAACATTTAA
+GCGTAAAGCCTAGCTATACCGACCAGCTTATGAATATTGCACTGGATGCGCAAACTATAG
+ACTACTATCACAACGGAGTTAACATAGTAGATTTACTTTAACGCTGGTATTATAATATAG
+ACATACATCCATATAAGAAGAGATCAGTAGCTTAATTGTCTGGCTGCTGGTCTTTTTTTG
+TTCGCTCTCATCCCTACCAGATGGCTTATATTAGCTTGCTGGCTAGGCTAATTGCGGTTC
+TCTTATGATTTATCATTTACACCTGTGGAGGTCTCACGCTGGCTTATATGCTTGTCTGCT
+TGGTCTTCTGGCTGTCCTGTCTTTTCGTTTTTGCTTTCTCTTTCACTGGTTTCATGCCTT
+GAGTTTCAGCAAGCTCAGCTAAAGAATTTAAATTAGCAACTAATTAATTAAGAAAGCTAG
+CCGTCCATACAATGGCTCTCTCAGCATATCGAGGGATGCGTACGAGCGTAGTTACAACTA
+CAGACATGCTAGCACTAATAGATTATTCATACCTGTCTGCTTTATGGTCACTCAATGTAA
+CCGCCGAAATAACTCGTTATCAATCTAATTGATTTAGAAAATTAAACCGCAATCAAAAAT
+AAGCAATGAATGAATTTAATTTCACTCACTGTTTTTTTATTTTGCACCCCGCCCTACCTT
+TCAACGTTGCAGAGCCACACATTGCTGTCGCCTCGTGTGAAACATCAGTTGTTTCACAAT
+TAATTGAGGGGGGTTATTTATAAACCTTATTACTACAGTATTTATATATGTATTCCTGCT
+ATTTCTAGACGGAAAAAAAAGGCTATTCAAACCTTTCTGGAATGAATAACCTTGACTGAA
+TTGATTCTTACTAGTTTTTATTATGCCGCTTCTTTATATTCGTGCAAGTCTAGAACATCT
+TTTACACCCTGTTTTAACTGTTCCATCAGATAAACATCGGCAAACTGCAAGAGCGCCCTT
+TTACGCAATACATTATATTGAGTGTGACCATATCCAAGGCAATTAGCAATGTCCCAGCTA
+GCTAAATGCTTAATATATCTAAGCTCTAGAATGCTCCTGTATGGCTTAGTTGGTTCATTG
+GTGCAATTGCCTATGGCTGGCTTTAAACACGCTAGACGGTCGTTATATGCAATTATTAAG
+TTATATCTGCTCGCCACTGCATCGGGATTAATTGAACTATTTACCTTGATATTATCAAAA
+TTCAAGCCGTGGACGTTGTACCGACCAGCGCACATTGTCTCATACCATTCTAAATCCTTA
+GCAAAAAATTTCTCCACGTTTTTAACTGTTTCTGGTTCATTGATTTCTAGCATACCTAGC
+AACTCCTATATTTATATATTATTGGAATATCTAACATAATTATATTTTACTATGTTTTAC
+CAGCTGGCTTATTAACTGCAAAATAAAAGAGCTACCTTAAAAAGGCAACTCAAGCCGACT
+AATTAAATATCTAAAATCAACCAATCAATACGCTATTACACTTTTAAGAATATGAAGCCT
+AATATGAAGCCCGAAAATACTATTTTTTATTAATTTGATTTAATCATAGAAAACAAAAAG
+CCTTTAATATCAACGTTTCTAATCCATTGACATTAAAGACTTTTAAATTTATGGAGATGA
+GGGGAATTGAACCCCTGTCCAAACGTATTCCGTCGTTAACCTCTACGATCATAGTTATAT
+TACTTAAACTTCGCTTTGATAAAACGCCATATAACAGGGCTAAACTATCAAAACTAACCT
+AAGAATCTTATTTCTAACTATTAAGGTAAGTAGTTAAACGTAGCTCGTTAAATGGTAAGA
+CCCGCAGACAGACACGAGCAATCCGTCATTGGATCACGCAGCCTGACTAAGCAGCTACTG
+CGTAAGAATTTTCGTTATTTGCAGTTATAATTTAACTGTGACGTTTTAACGTAGACGTGA
+CCTACGAATCGCAGTCAACGCGAATCTACGCCTGTCGAATCCCAAAACATCCCCAGATGT
+TTCAATGATATCACAGTCACTGTTAAAATGCTATAACTTTGCTTTCACAGCTATTTATCT
+AATTTAGCTAAACGAACAACGTCACGTGCAATCATTAACTCTTCATTTGTTGGAACGATC
+ATCGCAGTAATCTTTGATTTCGGTGTAGTGATAATTCCTTCCTTGTTAGCTTTATTAGCT
+TTTTCGTCATATTCAAGACCAAGCCAAGTAAGACCATCCATAATCTGTTTTCTTACACTT
+GCATCATGTTCACCGATTCCTGCAGTAAAGACTAAAACATCTAAGCCACCCATTTCAGTC
+ATATAAGCCCCAATATAGCGAACAATTCGGTTAATAAAAATGTCTTTTGTAAGTTTAGCC
+TGTTTATCACCATTTTTAATTGCTTTTTCAATGTCTCTCATATCTGGGGAGATTCCTGAA
+AGACCGAGTAAACCAGATTTAGTGTTTAACATCTTAATAATTTCATTAAAGCTGGTAATG
+TTGCCTTTTTTCATAATAAATTGAAGCAAGGAAGGATCTACATCCCCACTTCTAGTACTC
+ATTGTAATTCCTGCAACCGGACTGAATCCCATTGAAGTATCAAAAGACTTTCCATCTTTA
+ATAGCAGTAACTGATGCACCACTACCTAGATGACAAAGAACCATCTTCAAATCTTCAACT
+GGCTTCTTTAATAAGTCAGCTGTCCGACGTGATACATAGCGAGCAGAAGTACCATGTGCA
+CCATATTTTCTAGCACGGAACTTTTCATAATACTTATATGGTACTGAATATAAGTATTGA
+ACAGGATCTAATGATTGGTGAAAAGAAGTATCAAAAACAGCAACCTCAGGAACGTTAGGT
+AAAACTTTCATAAAAGCATAGATACCGTCGGCTTCAGCTGGGTTATGCAATGGTGCATAG
+TCACTCATATTATAAATCTTCCAAAGATTATCATCTGTAATGACTGTACTATCAGTAAAT
+TCTTCACCACCAGCAACAACACGATGTCCTACCCCAGCAATATCTGCTAAAGAATCGATC
+ACATTGTATTCTTTAAGCCAGCTAAGCAACTTTGGGACTGCTTCTTCTTGATTAGCAATA
+TCACTTTGTTCATCATGTTGACTGCCATCTGCTAAAGTCATTGTGAAAACAGATCCTGGC
+AAACCAACACGGTCAGCCATACCAGATGCAATTACTTTTTCATTATCTAGAGAAAATAAT
+TTGTATTTAAATGATGAACTACCTGAGTTTACTGCTAAAACTTTTTTCATTTTATATACC
+TCTCGTATTATATAAATTAATCTTCACTCTTATGATACCAGTCATTTAGTTTCATATTAA
+ATGCTACTAAAGATTCTGGTTTCTTTAATGAATCTAATTTAGCCACCAGAACCTCACGCT
+TAACAGCATGTTCTCCATGATTTTGAAAAACTAAAATAGATTTTTGTTGAATCTGACTTG
+AAAACATATCATCGGGCAAATCGACAATTGCCTGAATATTAACTTTTTTAGCTAACCAAG
+TCATGAATTCAGTAGATCCTTTACCAGTAAACAGTAATCTAGGTACTACTAAAAATGCAA
+AACCATCACGTTTAAGGTTATTTACTATTTGTTCAATAAATAAAGTATGAGCAAAAGAAT
+GTCCCTCTTTTGCGTGATTTTCGAAGCGCTCAGCATTATTATCCAATGGATAATAACCTA
+CTGGCACATCACTTACCACTATATCCGCCTTTTCAATCATCCATGGATCTAAAGCATCTT
+GACAGTATAAATCAATTTTTAAATCTTCAAGATGAGCACCAATATCTGCTAAATCCAATA
+ATGCTTCTTCATTATCAATTCCAATTAATTTGTAATTGTTTTGTGAATGATTTTCCTGAA
+TCAACTGTCTAATAACCGAATAAAGTAAATTTCCAGTTCCAATTGCGGGGTCAACCACAG
+TTTTTTTACCTTTAGAAACGATTCTTTGCCAAATTAAAGCAATTATTGTAGCAATCACTG
+AAGGTGTTGGCATCAAGTTATAGTCACTGGCATCTTGAGTAACTGCTTTTAAAGTTAATA
+GAGTAAATATTTGTACTTTTAGAGCACGTGGCAAATTATCATAATCTAATTGACGATACT
+CTTCAGTTAATTCAGCTACAGTTTCTTTATCTGGGGCACCCGATTCGACTTTGATCTTAC
+CATTTTCTAGATTATCAAAGGTTTCCGTTAATGCCGATGAAAAAGAGACATTCAGAGCTT
+TTTGTAAATGCTCAATAGCCTTCTGAAACTTTGGATATAATTCTTCTACTTTTTGCATTT
+TTCTTCCTTCTTTAATATTCCTTCTAATATTTTATAGGTATCATCAAATACTAGCAAGCA
+AACAATGTTACTTGGAAAAATAATTTATTAAAGAAAGATTACTTTCCATATTTTCAGTAA
+AACTATGTTGATACATCATTACGAAAGCAATACAAATATTAATAAGCAGTAAACTACTAA
+TTAAGGCACTTCCCTTAAGTCTTTTTACTATTATCTTTTTTCTCATCCTTTATTTTATCT
+TCCTTCTTCTCTGGTAAATCTGTTTTGAAAAACATCTCACTTTGCCTACCATCTTTTTCA
+GTTACTAAAATAGTAAAAGAATCTTTTGCAGTAGAACATTTTATTCTTTTAACTTGAAAA
+AGCAGTGGCATGTGCCCTCCCTCATCTGTTCTCATTCTCAAAACATCATTTGAACTCATA
+TCAATTACATATGTATCGTAAATTAAATCACCATTCTTTTTCTTCTTATCCGATAACTTT
+CTAAGAACAATTTTAGTTGGATCTGAACCAGTTGTACTTACTTCAACATGTCCACTTTCT
+TTTAAGAAATTATTTATTTGTACATAACTATACGTAATCTCATTAACTCCGGTTTTTTGG
+CGATTAATTTTTCTAAGTGTACCTACAAGTCCAAATAATATTTGTGCACATAAAATAGTA
+ACTGCGATTGCAAACACAGCTTCTAATAAGGTAAAGCCCTTTATCTTTTTCATTATTCTT
+ACCTACGATAGAGATGATCATGCACTAATAACGTTTTTTTATCACTATGTCTAAAAATAT
+ATTCCGCATATGCCTTATCTACTCGTTTTTCAATTTGTTTCTCAGTCTGCCTATTTTGTT
+TAATTGTCATCCCTAAAAGCAATACTCCTAGACAAGCTATCGTAAAGCCTACACATGCTT
+CCCACAAAATGAAGCCCTTTATTTTTCTATTCTTCAACCATCCTACCCCATGTCATCTGT
+ATTTTTATCTTTTTCTCTTTACTTCCACTCTTAACAGTAATTGTTCTTGGCGATATCGTT
+CCGCGATTGCTAATGTATAAATTATTAAAATTATAAACTCTAACATGTCGATTCAAATAT
+ACTTTTGATACTTGATGTGGCTCCATTATCTGAATTGAAGAATTATTGTCAAAATATGAT
+AAAAAATATGACTTCTTTTCTACTGTTGAACGGTGTAAATACTTATTTATAGTTGATCTA
+ATTTGACGCGTAGTACTATCCAAAATTATTTGTTCCTTAATATTTTTCACGTAAAGCGTT
+GGCATTAACACAAGTAAACAAACTATTGCTAAAGTAACTATCGTTTCAACTAAAGTAAAA
+GCCTTTATTCTCTTAAAAATCATTTTTGTGGTAATTTTTCATATCTCTCTTTTTGTTTTT
+GAGAAATATATTCTTTCTTTACCAGCTCTTCTAATGAAGTACCATCTCCATTATCTGCAG
+CTAATTGTCTTTGAGTCTCAACCGTTGTTCTTAAGGCTTCATCTGTTTTACTAGTTGCTC
+TCTCTTTTTGCTTACTTAGTCCTGGAACAATTAGCAAAATCAACATCGCAATAATGGCAA
+TTACAATTACCATTTCAACTAAGGTAAATCCTTTTACCCGTTTATTTTTCATAATAAATT
+GTTTTAACTTTTTCATTTTTCCCTCTACATTGTTTCCATTAAATGATACATTGGCATTAA
+AATTTTCAAATACATCCCCAGAATACAAATTCCAATAAAAATAAAGCATAGTGGCTGCAA
+ATTAACGATTAAACCATTTAATTTGAGATTTAGTTCATAAAAAAGTGTCTTGCTAAGTAA
+TAGCGCTCTTTTCCCAATTTGCTCTCTTGTTGTTCCGGTTTCTAAAAGCATAACTAAGTT
+ATTAGAAATAAAGGCTTCATTCTCAATAATTGTTTTAATCTCAGTTCCTTTTTCTAACTG
+ATTCTTCACTTTTGTTCCTAAGACTTGCTGTAATGAGTTCTTTGGTTGCTGATCAGTAAG
+TTGGCAAATTTTTTGTAATGAAAAGCCGTTGATTAATAAAACAGCTAAGTCAGACACGAT
+AAGATAGTGAACATATAAATTTAATGTTGGTCCAATTACAGGTATCCTAGTTAATTTCTT
+CAGTGCATAATAATCTTGCCTATTAAGTAGCCTGATTACCTTACTAATAAAAAATGCACC
+TATAATAACTAACATCACAAGTCCACCCAGCATTACATTACTCGTCCAGTCATTATCTGA
+CATTTCTGTCTTTAAAAAAGTTTGCATACAAATTAATAGCGTAACCATCATTCCAATTAA
+AAGTGCTGGATAAGCTAATTCTCCTCGCAGCTTCTTTAACTGCTTATTTTTCAAGCGAAT
+AAGTTTACTTAATTGGTCCAAACAAGACAATAAATTGCCATCAATAATTGCCATATTTAT
+TTGTGCAGCTAAAGTACTAGAAAATCCTACTTCATGCAATACATCCCCAAGTTGCCTACC
+TTCTTCAACCTGTTTACTTATATAAACTAATTGATTAGAATCACCACTCCATATTTTAGG
+CAGCAATTTTAAACTAGCATTAAGCGAATAACCGTTAATCAGTGCTTGTCTTAAATAATC
+AATAAAAATTAATTGAGCAGCGCTATTTAGCTTATCCTTCTTCATAAAGATGCTTCGTAT
+CTTCACTAATCTTTCCTCTTTCAACCAACTGCTCTAAAGCACTTTGCCAGTTGCGCAAAT
+CATGACGCTTATCATTAGACATAATAGCTTGATCAAGTATTTTTCCATATCCAATATCCA
+TTAAACAGGCAACTTTATTTCGATCTTTTATCGGTAACAATCTTTGATAAGAAGCAGCCG
+TCAAGCAATTGCACAATTCGTCTTTAGTGATTCCTAATCCTTCAAGCCGTGAAATTGTTT
+GTAAAGCTGTTTTTGCATGAATAGTTGCTAAAACCAAATGTCCACTTAGAGCTGCGTTAA
+TACTGATTTTGGCAGTTTCTTGGTCTCGAATTTCTCCAATAATTAAAATATCCGGTCTAT
+GACGTAAAGCAGCCTTTAGTAAATCTGGGTAAGTAATTCCCGCAACAAGATTCACTTGTG
+TTTGTAAAAAACTTGGATTCCAAACCTCGACTGGATCTTCAATAGTCATTACAACCTTTT
+TTTCTCCAACTAATTGCGCTAACTCATACATGGTTGAGGTCTTTCCTGATCCTGTCGGAC
+CGCTAGTCACTATCAGCCCACGTTGATTGGTGAGTCTTTTTAGCAAATCAAATTGTTCGG
+GGAGAAAATAATTATTACTTTTCCCTTCATAAATTAATCGAACTACTAAAGACTCATCTC
+CTTCAAATTCCCCTACACTTGAGAAGCGTAAAAAGACCTTTTCACCCCGAAATTCAGTCT
+GATACGCCCCCACTTGTGGTCTACGACGCTCAGATATATCCATTTGCGCCTGAAACTTGA
+AATAATTAAGTAATTCCTTTCCTACTTTCTGGCTTAATTCTTTTATTTTACTCAAACCTA
+GGGCAGTTCGAATCTTTATTTCATATCCTCTAATAGCGGGAAAAATAAAGATATCACTAG
+CATGGCTTTCAATTGCTTTTTCTAAAATAGCTTCTGATACTTCGTTCATAATTAATCCCT
+CCTTTGCCATACACTTATTAGTACGCGAAAATAGGCCATATTTTTTATCATTTTAAAAAT
+TAAGAAAAAAAAGACTGACACAAAGGTCAGCCATAAAAAATAGACCTAACAAAATTAGGT
+CTACTTCTTGATAAATTATTATTCATCATCATCTGCAGCAGCAGTATAAACATTAGAAAC
+ATCATCGTTATCTTCTAATGCATCAATTAAATGAGTAAATTGCTCTTTTTTATCTGCTGG
+AACTGGAGTGGTGTTTTGCGGAATCATAGTTAATTCAGCGTTAGCTAACTTGTAGCCAGC
+TTTTTCTAAAGCATCACGTACAGCAGTAAATTGCTTAGGATCAGTGTAGATTTCGAATGC
+ATCATCACTAGTTTCTAAATCATCCCCACCAGCATCCATAACATCAAGTAAAACTTGGTC
+TTCATCAGCATCAGTAGTGGAACGATCAATTACGATGTAACCCTTACGGTCAAACATGTA
+AGCAACGGAACCAGTTGCACCGAGTGAACCACCATTACGAGTAAAGGCAACACGGACATC
+AGAAGCAGTACGGTTCTTGTTATCAGTTAAAGCTTCAACTAAAACTGCAACACCACCTGG
+TGCATAGCCTTCATAGGTAATTTCATCATAATGTTCATCTGAATTACCTTCAGCCTTCTT
+AATAGCACGTTCAATGTTAGTCTTAGGCATGTTTGCTGCACGTGCTTTATCCATAACCAT
+ACGTAAAGTAGGATTTCCTGAAGGGTCAGGACCACCACTCTTTGCAGCCATATAAATTTC
+ACGAGATAATTTTTGGAAAACTTTACCTCTCTTAGCGTCTTGCGCATTCTTGCGGCCTTG
+AATATTGTGCCATTTTGAATGTCCTGACATAAGAATCCTTCTTTCTTTTTATTTAATATA
+GTTAACCTTGTCAATCATAACGCACTCAAGGTTTAAATTCAATCTATGATTAATTAGGAA
+TTGCTTTTTTCTTGATGGTGTCTAATCCAGTAAACAAAAATACAGAGTAAAATAGCTAAA
+AGCGCTCCAGCTGAATCAAGAGCAACATCGTGAAGACTTGGGGTTCTATCTCCTGTCAAA
+TATTGATGAAATTCATCTAATCCAGCTAATCCAATAATTCCTAACCAGATAAACAAAGGT
+CCACACCATTTTTTAAATAAACGATCTAATCCTAAACAAGCAAATAAACCAACTAAAAAA
+TACGATGAAAAATGGGCAAATTTTCTCATGACAAATTGTGTCATTCCAGCTTCCCCATTG
+TCTAAAAATGCATTATGCCAGCGACCAGCATAATAAATATTCCATTTTCCAACTATTCTT
+TCAATAATCGGAAAATGTCGATGAATAAATCCTGGTGACATCTCTTGTTCGTGATAAGTC
+ATCGAACTGGAAATAAATAAACCTAAAAGCACTAAGAGCATCAAACAGACAAAGATCATT
+TCTCGCTTAGTTAATACTGTTTTTTTCATTTTTCAACTTTCCTACTTTCAAGTTCTTCAG
+CAACCAAAACAATTATTTTTTTAGCAATTTCAACTTTAGTTGTTTCTGTAATATTTTCAG
+TTGTTTTATCTTGCCTTAAAACCATGACTTTATCTTCATCACTACCAAATACTCCATGAC
+TGACATCATTTGCAACAATCATGTCAGCTTTTTTCTCTTGCAATTTTTTCGAAGCATTTT
+CTAATAAGTTATTTGTTTCAGCAGCAAAACCAACAACAACTTGATTCGCTTTTTTTATAC
+TTCCCATTTTTTTCAAAATATCAGGAGTTTCTTTCAAATAAATTTTTAACTCATCCCCCT
+GATCCTGCTTTTTGATTTTATGAGCAATATAATTTACCGGTTCATAATCTGCTACAGCTG
+CTGCCATAATTAAAGCATCTGCACCTAAAAAAGCTGTCTTAACTGCTGAGAGCATCTGTT
+CTGTAGTTTCTACCTTAATGTTTTTTAAACTAGGCGAATTAGGTAATGAGACAGCAATAT
+GACCCGAAATTAAAATCACCTCGGCTCCAGCAACAAGAGCAGCTTTAGCTAAAGCTATTC
+CCATCTTACCACTTGAACGGTTACCTAAAAAACGAACCGGATCAAGCGGAGATATTGTTC
+CACCTGCAGTAATTACAATTTTTTTACCAGCTAATATTTGTTTAGCTTGAAAAGAATCAT
+CTATCCAAGCCATAATGTTATCTGGCTCTGGCATCCTTCCCTTACCACTATATCCTTCAG
+CTAAGCGCCCAGTAGCAGAATCCATTACCGCAATTCCATCTTGTTTTAATAAGGCTAGAT
+TTCTTTGAAAGGCTGGATTACTCCACATATGACTATTCATAGCTGGAACTACATATTTAG
+GTGAAGCTGTTGCTAGGAAAGTTGTACTTGCCGCATCATCAGCAATACCATTTGCAATTT
+TAGCAATAAAATTAGCCGTTGCTGGAACTACAACAGCAATTTCTGTCCAATCGGCTAATT
+CAATGTGCTGAATCTGATCAGCTCTTTCTTTTTCCCAGAGATCAGTCAACACTGGATACT
+TAGTTAAAGCAGCTAATGTTTGCGTACCGATTAAATGGACAGCTTCTTTTGTCATAACTA
+CTCTTACTTCATGTCCCTCTTTTTGAAAATTTCGTACAACGTTAATTGCTTTATAGGCGG
+CAATACTACCTGTAATATAAACTGTAGCTTTCATTTTTCTCAACCTTAATTTCATAATTT
+CTTTCTACTATAACACAAGCTAACTAAGACAAATTATTAAAAAATAAATTATCAAATTAA
+AAATCATTAACGGATTCTGATATGATTTATATTGAATAAAGATATCGATCACATACCTTG
+AAAGGATAAATATACAAAATGAAAAAATATTATCAAAAGATTTTTTCTCTCTTTATTGTA
+ATGGGGGCTTTATTTCTAGTTCTTACTGGCTGCTCCAAAAAAGAAAATTCATCGTCTAAC
+AAAATCTCGATTGTTACCAGCACCAATGTTTATGCTAATATTGCACAAAATGTTTTAGGT
+AAGTACGGCAAAGCAACAGCCATTATTACTAGTAGTTCCACCGATCCCCACGATTTTGAA
+CCAACTACTGCAGATGCAAAAAAAGTTCAAGATGCCAAAATTGTTGTAGCTAATGGTTTA
+GGATATGATTCCTGGCTAGCAAAACTGGCTAAATCAAGTAATAAGTCTGCTGTTTTAGTT
+GGTGAAGACTTAATGAATTTGAAAAGCGGTGATAATCCTCATATCTGGTTTGACTTAAAT
+ATGCCAACAAAATATGTCAACTATTTGGTAAAGCGCTTATCTAAAATTGATAAAAAACAC
+GCAAACTATTATAAAGAGAATGGAATTAAATATTTAGCAAAAATCAAAAAAGTCAAAAAA
+ATAGCTGATTCAATTGATGGTACAAAACAAAAACCAGTATATGTTAGTGAACCAGTATTC
+GACTATGCTTTGAAAGCCACCCACTTTAAGATTGGCGATAAAGATTTTGAAGAGGCAATC
+GAAAATGAAACTGATCCGAGTGCCAAAATTGTTCATCAAATGAATCAAACTATTAATAAT
+CGTGGTATCTCTTTCTTTGTTAAAAACTCCCAAGTAAGTAGTTCTACCGTTAACAATTTC
+GTTAAAAGAGCCAAATCAAAGAAGATTCCAATCTTGCAAGTTCGTGAAACTATTCCAAAC
+AATACAACTTATTTGAAATGGATGACAGAAAATTATCAAAATTTAGCAAATATCGCTAAA
+AAGTTAAAATAATTACCAAAAAAGAGGCATGAGCCTCTTTTTTATTACCCTAAAATATCC
+TTTAATTTGTTATTAAATTGCTTAGGAATTTCTGCCATAATTACGTGACCAGTTGGTGAC
+ATAATAAAACTATCTACTTGATCATTTTTTTCTTCAAGCAACTTTTCATATCCTTCACGA
+TAATACGGACTCTCCTTAGCAATAAAAAAAGTAATCGGAATTGTTGCGTTTTCTATAACT
+TTTCGCCAATCTAAGGACATATGATTTTCTAACAAGTCCACATTATCTTTTCTATTAAAG
+GGGTTTTCTTCTTTTGCTTTCATAAGTTTGGCATAAACACCATCATCTAGTCCTGCGAAA
+GTTTCATGAACATGGGGTCTTTCCTGACATTTTTTATGATAATTTTCACTTGTATAGTCC
+ATAAAGCCATACTTCCAATTCTTATCATTAAGCATCTTAGGTGATTGATCTACCACTAAT
+GCACGCTTAACAACAGTTGGCCATCTTTTTATTAGACAGAAAATAATCGAAGCGCCCATT
+GAATGTCCCATGAAAATAGCCTGTTTAATTTTCAGAAAAGAAATTAATTCTTCTAAATCT
+TGTGTTAAACGAACAATATTATGTCCTCTTTCTGTGCGTTGGCTCTTCCCCATATTTCGG
+TGGTCATAAGTAAGTACTTGATACCCTAAATTATTAAGAAATGGTACTTGAGCAGACCAT
+ATTTCTTGATATGCACCAAAACCATTTACTAGGACAATCGTCTTCCCTTTCCCAGTTAAT
+TCATAATTAATTTTTACATTATCACTTGTTTCAAACAGCATTTTTACTCCTTATTCTGTT
+TAATTCTAATGAATAAACATCCAACTGCAGCAATAATCGCAATAATCAAAGCTTGACTTA
+ATCCACTACTTAAGCTTACGTTGATCCCGTCATAAACGCTTTGCTGGAGCGAGCTTGTGG
+CAATTCCAGCCGCGTATGATAAAACACCATATGAACCAATTGCAGCAATCATAAGCGGTA
+AAATTGCAATCTTTTTACCAAATAAAACCATTACCATTGCCAAAATGTAGAGACCAATTA
+GTAGGAAATAAATCAAATGATAAATCTCAGCTGCTTGTTTTACATCCGCAGAATTCTGTC
+TTAATTGTTCATTTACTAATTGCAATATTAACTGATTAAAAACTTGTTCTTGTTGCGTAT
+CATTATTTAGTTTTAGATCAGATGCAGCTAATTTACCATTGGCTAAATAATTAGTACTCA
+ATTGATTTAGCCCTTGATATGATGTTTTTAATTCAATATTCTTGGGTAATTGTGATAAAA
+GCGTATCTTCGATTCCCGATTCTTGCAAAAAACTGACTCCCATTTGCAAATCACTATTAT
+TCGCTTGGTCAACTACCTTATTAATTGAGCTTTTCACAAGACCAGCAGTACTATCAACTT
+TCAATTCAACTGGACTTGTTAAAGTCAAACTTAGTGAGATAAAGATTAATCCAATTACAA
+CTAATCTCCAAATCCATTTTATTAATTTCATTTTTTCTCCTAACGAAAATTTTAATAGTC
+TTTTATAATCGCTAAAATACTACATAAAGTTTTTTTTAGTGCTATATAATAAAAGTGTAA
+CAAATATTAAAGGAGTTCAGCATGATTGATGAAAAACTAAAAGAATTTTTCAATAAATTT
+CCTCATATTAAGGAAAATAAGCCTTTACAAAATACTCTGAGCAAGAAAATCAACAACCTA
+ATAAAAAAAGAAATCCAACATGGTGCAAGTCAAGTTGAAGCGGAACAGAAAGCACTTTTA
+AATTTAACAGATCTAGACACTCTATTATCACAACTAAAAAATTTAGAAGAAACTGACTAC
+AGTAAATATAATGATTTCTTTGCTAAAATCTTTGATTCAAAATTAGTTAATGAATTAAAA
+CTTAAATTAAATCAAATTGATGAAATTCACCTTAATTACCGCTTGGGTGATATTTTAGTA
+TTACCCACTAATTCATCAAACTTAATTGTGCATGATTTTATGTCTAGAGATATTGAAAAT
+CTTCATTCAACGGTCGAAAAAATTGGTAACGTCTTAAAAATTACTCAAGGTCCACGTAAG
+CTGGTAGGAATTTTCAAAAATAAAACTTTATTATTTTTACCTAAAAATTTTACTGGCTTC
+CTAACAATCAGAAGTCAAAGTGGTGATATCTATATTAATAAAGTTCCAAATTATTGTATG
+CTGGATGTTACTGCAGTTTCTGGCAATTTATTATTGGCTCATTCTAAACTTAAACGTGTT
+CAAGCAGACTTAAAGTCAGGCGACATTGCTGTTTCTAATACATCTGCAAATGTATTTCAC
+ATTAATGCTCATTCTGGAATTCTAACTAGCGATCATGTTTGTGCAAAAGAAGAGATTTCT
+TATCATACAAGTAGTGGAAATATAGACTTAGAAAGTATTTCTACTAAAAACTTTTTTATC
+GATACTAAGAGTGGAAAAATTACTATTAATGACCTTAATAGCGAAAGAATGGATTTAGTT
+ACTGATACAGGAAATATGAGCTTAAATAAGGTTAACGGTAGCGGTGATATTAAGTCTGGA
+ATTGGGAAAATATCCTTATCAATTGCTGATAAATCTAATTTTAATTTTTCAATCACAAGT
+AAAGTTGGAAGTATCCGCGTAAATGTACCAAAGAAAGAATTATTTAAATTCAAAATCAAT
+ACTAAAAAAATCGGCCCTACTGATCTTCCACTTGACTCCATTATTTATGGTAATAATGAA
+TATGATGAAATTGAAGGATATGTTGGTAATGAAAATTCAAGTAACTCACTAACGATCACA
+AGTGAAATTGGAAAAGTATCAATTAAGAACGAAAATTAAACAACTTCAAGCGAAAATGCT
+AGCAAACCTAAAATTTGCTAGCATTTTTTCTAAATTATTAAGCCTGCTTTATATCCTGCA
+AAAACTAAAATTAAGCCGCCACCATAGGATAATAAAGCATAAAGAAGGAATGTTTTGTAA
+TTATGATCCTGCCAATGAGAAAGCAACTCAACATTTAATGTGGAAAAGGTCGTATAACCT
+CCCAGTACCCCGGTTCCAACTAAAGCATAAACAAATGGCGAAAAATTGCGCGAAAAAACT
+AGCCCTAACAAAAATGCCCCAGTAAGATTTATTAATAAAGTAGCATAAGGAAAGTTGCTA
+GACCAATGTTTTTTACCATAATTAGTAATTCCGTACCTAAGAATTGCTCCCCAAATTGCT
+CCAAAACCAGCTGTTACAAGTGTCGTTATCATGCTCTTATTGCCAACTTTCTACCCAATA
+TTTTTCCTGTAATCATTCCTAAATAAGCAAATAAAAATCCAATAAAGATTGAACTAAAGA
+AATATATCAGCGCCTGATTATTCATTCCGCTTTCTAATTGCTTGAATGTATCCAAATGGA
+AACTAGAAAAGGTTGTAAATGCTCCTACAAAACCTGTACTTAATCCTGTAACTAGCCAAT
+CTCGTCCTTCCCTAAATTCAATAAAGAAATATGTTAGAAAGGCTAATAAAAAGCAACCAA
+TAATATTAGCTACAAAAGTTCCAGCCTGTGACCAAATCACATTTAAATAAGCACGTAATG
+CTCCTCCACAAAATGCAAATAAACCAACACTGATATAATTTTTCAACTTTTTATTCATTA
+AAAATCAACCTTCTTATTGCATACGCAATTCCATCTTCATTATTTGTTCGAGTAACATAA
+TTAGCTCGCTTCTTTATCTCTAATACCGCGTTTCCCATAGCTACTTTATAAAAATCTGGA
+ACGTCAAACATGGAAATATCATTCTTTTGATCACCAAAAATCATTATTTCATCTTGTCTA
+AGATTAAGTTTCTGCGCCAATTCTTTTAAAGCGTTTCCTTTTGAAGCTTGCTTAGAATTA
+ATTTCGATTAATGTTTTATCAGAGGTAGAAACGTTATATTTTTCAATAACTTCTTTGGGC
+AGGTGCCGATAAACTCTTTCCATTTCTGATGGAGCACCTGAAAACATGGCTTTTGTAAAT
+TTTAAATCTTTAGCTATATCTTTAAATCCACAAACCTCAATCGACATTCTAGTCAGCCAG
+CTTTCACGCGATAAATAATAATTAATAAAGTGATCTAATGTAATAAATTTATCACTCACT
+TCAATATGAAAGTTAGCCTTCAATTGTTGAGCTATTTTTTCAAAAAAAAGGAAATCTTGA
+TAACTTAATAATTCTTCAACTACTGCATTTCCTTGTGCATTCAAAACTAGAGCACCATTA
+AAAGCCACAACATATTGATTAGGATCTTGCAGATCTAACTGATCTAAATACTCTTTAATT
+CCTGGAAATGGTCGCCCCGAACAAGGAACAATTTTAATTCCTAATCGAGATGCTTTTTGT
+AAAGCTTCCCTTGTTTTAACACTTATTTCTTGTTTATCATTCAATAAAGTTCCATCAAGG
+TCAACGGCAATTAATTTTGTCTTCATCAATTTTCTCCTATGTAATCGTTCACTTTCCTTT
+CTATTATACAAAAAAAGACGACACTACTCCCTTATTACACATAAGAAAGTAGGCGTCGTC
+AGATCTTAATCGGTTAAATTGGTGAACGCCATCACCTATTATAATTTAATAAAAACAGTT
+TACTTTGAGCACATCTCTTCTTCAACGACCTTAGCAACTTCTTCACAATACCCATCAGCT
+AATTCTTGTGTTGGTGCTTCAGTCATAACACGGAGTAAGCTTTGAGTTCCAGATGGACGA
+ACAAAAATCCGTCCTTCATCGCTCAACTCTTCCTCTACCTTTTTAATAGCTTCGGTAATT
+CGCTTATGTTCTTTCCAGTCTTTCTTATCTTTGACAGGAACATTGATTAAGCGTTGTGGA
+TATTCTTTAAAGTCGCTTAATAATTCACTTAATGACTTACCAGTATCCTTCATTACGTAT
+AATAAATGCAATCCGGTAAGCATTCCATCACCAGTATTATGATAGTCACTGATAATAACG
+TGACCAGATTGTTCACCGCCTAGATTATAACCATTAGCTCTCATTTCTTCTGAAACATAA
+CGGTCACCAACTTGAGTTCTGACATTCTTAAGGCCGCGTCTTTCTAAAGCCTTAGTAAAG
+CCTAAGTTACTCATTACAGTTGTAACAATCGTATCTTTCTTTAAACGGCCATGATCGGCA
+AGATAGGAACCAATTACATACATAATATGGTCGCCATCAACTTCATTACCGTTTTCATCA
+ACAGCGATACAACGATCAGCATCCCCATCGAATGCTAAGCCCAGTTGAGCACCTTGCTTT
+ACAACTTCTTCTTGTAACTTTTTAGTATGAGTTGCACCTACATGATCATTAATATTTAAG
+CCATTGGGATGAGTTGCGATTGTAGTAAAATCAACGCCCATATCAGCAAATAATCTTGAA
+ATCAAAGCACTAGCTGCACCATTTGCACCATCTACAACAACTTTAATTCCACCTAATTCT
+TCAGGTAAAGTATTTTCAATAAATTGCAAGTACTTTGAAGCACCTTCGTGGTAATTAGTT
+ACAGTACCTAAGCCTTCAGCTGAAGGACGTGGAAGCTTATCTTCTGGTGCATCAATTAAT
+TTTTCAATTTCTTCTTCTTTAGCATCAGATAGTTTCAAACCATCACTACCAAAGAACTTA
+ATTCCATTATCTTCAACTGGATTATGAGATGCTGAAATTTGAACCCCAGCATCTGCACCT
+TGAGCACGAACTAAGTAAGAAAGGCCCGGTGTTGTAATCACACCAACTTCTAAAACTTCA
+ATTCCGACGGAAAGTAAACCAGAAATCAATGCATACTCTAACATTTGTCCAGAAATACGA
+GTATCGCGTGAAACTAATACTTTCGCTCTTTCTCCATCTTTTTTATCTTTTGTAAGAACA
+TATCCTCCATCACGACCTAATTTAAAAGCCATTTCTGGAGTTAAGCCAGCATTAGCAACC
+CCCCGTACACCATCTGTTCCAAAATATTTAAGCATAATTTAACAACCTTTCCTTGTTTTA
+TTCTTTTTTAGCAGTAGTATCAGTTACCTTAATATGAACTGGTATTACTGATGGTGAAGC
+CTTAACTACGCCCTTCGGCAATTTAATTGTTACATCTTTTGTAACATCTCGATTGATACC
+ACTTAAATCAACTTTTAAGGGAAGAGATGTTATCTTCTTTAGCGTATTCTCATCACCATA
+TATCTCAACTGTCTCTACTTTTGCGGTTAATGAGTAAACATGAGTTGATGATTCATTTTT
+GGACGTCACGTTTATTTTAACCTTCTTTTTCGACAAGTTAATTGGGATAGTAATGTGCGC
+TGTTGCTGGATCAATAGCAACATTGAGTTGATGTCCCTCTTTATCAAGTGCTACCAGCAT
+TTCTTCACGCTCAAATGTGCTGTCTATTCCCTTTGGTAAATTTGCGTGAGCTACAACACG
+ATCAACTTGGTTAACCTCGCTCTTAGCGCCAGTAATGTTCACAACTTCTGGATCACTCTT
+TGCTGTGCCAAGATTATACCCATGAGATACAGCACTCTTATTATACTCTATTTGCACAGG
+AAGGGTACGAGATTTTCTCTTTTGAATGTTTACACGTACTTTACTTGGACTCACACTATA
+AGTTAATTGAGTACTTAAACCATTTACCTTAATTGGCACCGTATGTTCTCCAGTTTTTAA
+ATGGCTTAAATCAATATAAACACGGAAATTTTGAGTATTAATAGTAGAAGTAACCAGCGC
+ATTTGATCCTTCTAAAGTAAGATTTATTTTTTCAGGATAACCAGTTACATAATATTTATC
+CGTATTAACAGAAACTTGTAGAGGAGCTTTAATTACTTGCGTCTTAGTTGCAGTTTTCAA
+AGTTTCTTCTCGACGTCCTTGAGTTACAAATCCCTGTTGATTAGACGAAACATAAATAGC
+CAGTAAAATTGCCAATATCAATGCAACAATGCGATAGAACCAAGGTTTATCAAAAAACTT
+TTTCATTTTTTATTTGACCCCCAATTCCAAACATGGTTTACAATTCGTTGATACCATTTC
+GGCTTTTCTTCTTCTTCCTTTGGAACTAGTTGAGCATTTAAGTACTTCAAATACTCTTCT
+CTAGTCAAATCAAGCATAAACTGGCTATTACGAGTAATTGTTACCCCACCAGTTTCTTCA
+GATACAACAATTGTAATCGCATCAGTAACTTCTGAAATACCTACCGCAGCCCGGTGACGA
+GTTCCAAGTTTTTTAGGAATCATACTATTATCTGAAAGTGGTAAATACGCAGCAGCAACT
+GCAATCCGATTATTTCTAATAATTACTGCACCATCATGCAATGGAGTGTTAGGAATAAAG
+ATGTTGATTAATAACTCGCCAGTAATATCTGCATCAATTGGAATACCTGTTTCAATATAA
+TCCTCTAAACCAGTATTTTGCTGAATTGTAATTAAAGCACCGATTCTTCTTTTGGACATA
+TATTGAATCGCCTTATCTAGTTCTCCAATCATTTTTTCAGCGGCCTGTTTTTCAGTCATA
+GTTGTGCCACCAAAAATTGGCGATCTTCCTAAATGTTCAAGTCCACGTCTAATTTCTGGT
+TGAAAAATAACGATTATTCCAATTACAGACCATGAAAGAATTTGATCAACGAAATACGTT
+AGTGTATGTAAGTGCAATAAACCGGCTATAATTCTAACTATGATAATTAGTGATATTCCT
+TTAACTAATTGAACAGCCTTGGTTCCTCTTACCAACATAATTAAGCGATAAATAATATAC
+CAAACAATCAGAATATCAATAATATTCATTAAATTTTGCCAAGTAAATATTTGCTCGATG
+TTAAATTTCACTACCCATCCCTCCTAAACCTTAATTATACCTAAACTACTGTCTTATCGA
+CCATACATTTTAAATTCAAGAAATAGATCATTATATTCCTGAATTTTCTTAGGACCTAAA
+TCCTGATAGACTTGTAAATTTTTCATTGCTTGTTTACTTGGATAAAATTGCTTATCGTTT
+TTTATCTCTTTAGGTAATAATTTTTGAGCTTTGATATTTGGCGTTGCATAACCAATATAC
+TCCGCATTTTGAGCAGCATTTTTTGGATCAAGCATGAAATTAATAAAAGCATATGCTCCT
+GCTTTATTTTTGACAGTGCGAGGAATAACAAAATTATCAAACCACAAGTTTGAACCTTCT
+GGTGGAACCACATAATGTAAATGCTTATTATCACTTAACATTGTCCGCGCTTCGCCAGAC
+CATGTTACACCAACTGCTGCCTCATTCTGAATCATATACATTTTTAGCTCATCAGAAATA
+ATCGCTTTTACATTGGGACCTAATCCATCTAATTTAGTTTTAGCTAATTTAAGATCTAAT
+GAATTAGTAGTATTTAACGACTTTCCCATCGATGCTAATGAAAGTCCCATAATATCTCTA
+GCAGAATCAACTAATAAAATATTATGACGATACTTTTTTGACCAAAGATCGTTCCAGTGC
+TTTATTTGTCCCGGTTTTACAAACTTATCATTATATACAATTCCTAAAGTTCCCCAAAAA
+TACGGGACTGAATAAGTATTCTTAGGATCAAATGAGTGATGCAAAAATTCACTCCCAATA
+TTTTTATAATTTGGAATTTTTTTGGTATCAATTTTCTCAAGTAACTTAGCCTTTCGCATT
+TTCGAAATCATGTAATCCGAAGGAACACAAATATCGTAAGCGGTGCCTCCTTGCTTTATC
+TTCGTATACATAGCTTCATTAGAATCAAAAGTTTCATAAATTACATGATAGCCAGTTTGC
+TTTTCGAATTTTTTTATCAATTTAGGATCAATATAATCACCCCAATTATAAATAATTAAA
+TTCTTATTATTGGCGCTAACACCGCTATTATCTAACTGCTTAGCCCAAGCCTCTAATCCC
+AAGCAAACTGCTAGAATAGCAAAAATTCCAATCAATAACTTTTTCATTGTGCACGCCCCT
+TACCGATATGGGATTTATGATTAGTAATTACATAATAAATTAATACCAAAACCATTACGA
+AGATAAACATTAAGGTACTTAAAGCATTAATTTCTAAATTAATACCCTGCCGTGCGCGTG
+AATATATTTCTACAGATAATGTTGAAAAACCATTTCCAGTCACAAAAAAAGTAACTGCAA
+AATCATCTAATGAATAAGTCAAAGCCATAAAAAAGCCAGCGAGAATTCCTGGTGTAATAG
+CTGGAATCATTACTTTACTATAAACTTGCCAAGTAGAAGCACCTAAATCTCTAGCAGCAT
+CGACCAAAGAGTAATCAAACTCCTTTAAACGCGGCAAAACCATTAAGACAACAATCGGAA
+TCGAAAATGCAATATGACTTAATAATACTGAACCAAAGCCCAAACCAATTCCTAAAAAAG
+TAAAAAAGATTAAAAAGCTGGCACCAATAATTACATCTGGTGAAACCATCAAAACGTTAT
+TTAACGCTAATAATGTTTTTTGGCCTTTTTTATTTTTAGTCTGACTAATTGCAATTGCTC
+CAAAAGTTCCAATTACTGTTGCAATCAAACTAGATAAGAGAGCTAATAAGATTGTTTCTA
+AAAAAATGGCTAGTAGTCGATTATCGTTAAATAAGTCTTGATAATGACTCAAAGTAAATT
+TTTCAAAATGATCCATATTATGACCACTCGAAAAAGAATAATATATTAAATAAAAAATAG
+GTAAATACATCGAAACAAGGACAAAAGCAAAATAAATCCGAGACCATTTTATTTTTTTCA
+TAGCTTGATCTCCTTTTTACGACGATGATCAGACGAAGTAAATAGCATAACAATTACCAT
+CAATACTATTAATACAACTCCAATTGTCGATCCCATTGACCAATTCATCGTAGTCATAAA
+ATATTCTTCAATTGCAGTACCAAGCGTAATTACTCTGTTTCCGCCAATCAATCTTGTCAA
+CATGAATAAAGAAAGTGACGGAATAAATACTGCTTGAATTCCCGACTCAACTCCAGATTT
+AGAAAGTGGCCATAAAACCTTAATAAACGTTTGCCACTTACTTGCTCCTAAATCATAAGC
+AGCTTGAATTACAGCCGGATTAATATCACAAATTGCATTATAAATTGGCAAAATCATAAA
+TGGAATTTCAATATAAGCTGCTACAAAAATAAAAGCAAAATCAGTAAATAAAATATTCGC
+TGGAGCGATGCCAAAAAGCCTTAAAAAGTTATTTAGTAATCCATGTTTGCCGAAGATTCC
+AATAAATGCATACGCTTTTAAAAGTAAATTAATCCAAGTAGGTAGAATAATCAAAAGCAG
+CCAAAATTGCTGATTTTTCATTTGACTTAAAATATATGCAATTGGGTAGGAAATCAACAA
+CGTAATTAAGGTAATTAAAAACGCATACCAAAAGGAATTTAGCGTCATTCTCAAAAAAGT
+TCCATTGACAAAAAACTGCTGGAAATTTTTCAAGGTAAATCCATCATCACCTTTAAAGGC
+ATTAATAGTAATTAAAATAATCGGAGCAATCACAAATAAACTAAGCCAAAGTACATAGGG
+TACAAGAAAAAATAGCCTGCTCTTTTTCATATCTTACTCGTCTCCTTCATATGCCTCTAA
+GCGTTTATCAAATTCTGCTTCGCTTTCACCAAAACGCATCACATGAATATCTTCAGGATC
+AAAATATACTCCTACTTCTTTTCCAATATTAGTTGGATTAGTTGAGTGAATCAGCCATTC
+ATTTTCATCACTATCAATGGCTTTAATTTCAAAATGATCACCCAAAAAGAGCTGACTTTC
+AACCATAACTCTTAATTTTCCATGCTCAATATCAGTAATATCTAGATCTTCTGGTCTTAA
+AACAACTTCTACTTTTTCTCCTGGTTTAATTCCAGCGTCAGCACATTCAAAACGATGATT
+ACCAAATTCTACTTCATAATCTTTAATCATTCTTCCACTCAGAATATTTGAATCACCTAT
+AAAGCGAGCTACGAAATCATTAACTGGCTCATCGTAAATATCAACTGGACTTCCGCTTTG
+TTGGATTTTTCCTTCATTTAAAACAAAAATCTCATCACTCATAGCTAAAGCTTCTTCTTG
+ATCATGAGTAACAAAAATAAATGTAATCCCCAGTTTCTTTTGAATTTCACGTAATTCAAA
+TTGCATGTCTTTTCTTAAACGCTTATCTAAAGCCGATAAAGACTCGTCTAAAAGTAGAAC
+TTTTGGCTGATTAACAATTGCTCTTGCAATTGCAACACGTTGCTGTTGTCCACCACTTAA
+TTCAGAAATTTCGCGATTTGCAAAGCCATCTAACTGAACCATATGCAGAGCTTCTTTAAC
+GGCCGATTTTATTTCTTGCTTATCCTTTTTCTTTATTTGCAAGCCAAAAGCTACATTTTC
+AAAAACATTCATATGCGGAAATAAAGCATAATTCTGAAAAACCGTATTAATTTTTCTCTT
+GGCTGCATCTAAGTTAGTAATATCTTTTCCATCAAAAAATACTTGACCACTTGTTGGTTC
+ACTAAATCCAGCAATTATTCTTAAAATAGTGGTCTTTCCTGACCCTGATGGTCCTAGCAA
+TGAATAGAATTTTCCTGATTCAATCGTCAAATTAATATCTTTTAGAGCCACAAAACCATC
+ATCATACTCTTTACGTACATGCGTTAATTTAATAATATCGCTCAACTTTTTCACCATCTC
+ATCAAAAAAGCTACAAGCCGTTACTTGTAGCTTTGTCGTAGTATCTAATCTTTTTCTTTT
+CCTATAATTCTTACTTCAGTCTGCAAATCAACATCAAAATCTTTTTTGATTGTTTTTTGA
+ATTAAATGAATTAAATCTAAATAATCAGTAGCCGTAGCACCACCAACATTAACAATAAAG
+CCAGCATGCTTCTTTGAATCTTCCGCTCCACCAATTCTTTTTCCTTGAAGACCAGCTTTA
+ATTATCATTGGGCCTACAAAATGACCTGTTGGACGTTTAAAGACACTTCCACAAGAAGGA
+TATTCAAGTGGTTGCTTTGCTCTACGTAAGCCATTGAAGTATTCCATTTTAGCCTTAATT
+GCCCACTTATCTCCTGGTTCAAGTCCAAAAGTAGCACTAATTACAATATCTCCAGTTTCC
+TGAACTAGTGAATGACGATAGCCAAATTCCATTTCATCGTGAGTATAAGTTTTAAATTTG
+CCTTCACGAGTTAAGACCCGAACAGATTTAATGACAAATTCCGTCTCGCCGCCATAAGCA
+CCAGCATTCATGAAGACGGCTCCGCCGACGCTGCCCGGGATTCCTGCTGCAAACTCTAAG
+CCACTTAAACTAGCTTCACAGGCTGCTTCAGACGTATCGATAATTCTCGCTCCAGCATCC
+GCAGTAACTGTTGCTTCTTCTTGATTTGCAACAATTTTATCCATTTTAGTAAGAATTAAA
+ACTAGACCCGCAATTCCTCCATCTCTAATAATTAAGTTAGAAGCATTTCCAATAACAGTT
+AAAGGTAAGTTATTAGTTTTAACTGTTTCCACTAAGATTTTTAATTCTTCTAAATTTTTA
+GGAAAAGCAAGATATTGCGCAGGCCCACCGGTCTTAGTAAACGTAAAGCGGCTCAATGGA
+ATATTTTCTTGAATATCAATTCCCTGTTTTTTCAAATCCATCAGTTGCATTTTCAATCTC
+TCTTTTCCTTAAATAATCGTCCCTTTAATCATACCGCAATAAATAGCTAGTTTTCTACCT
+TAAGTGTTATACTAAAAAGAAAAATAATAATTTATTTAGAGGATAAAAATGAACTTTACT
+GCAATGGATTTTGAAACGGCAAACAGTCATCCTGAAAGTGCATGTTCTCTTGCCTTAGTT
+ATGGTTAGAAACAATGAAATTGTCGACCGTTTTTATACAGTTATTAATCCGCAAATGCCT
+TTTGATAGTCGAAATATCAGAGTTCATGGTATTACTGCCGAAGACGTTAAAAATGCACCA
+ACAATGGCTGAGGTTTGGCCTAAAATTAAAAAATTATATCAGCCGGGAATGTTAGTAGCT
+GCTCATAATGCACGTTTTGACTGCCGGGTGATGGAAAAGTCACTTGCTCGCTATAATATT
+CCAGCCCCTCACTACTTTGCAATTGATACTTTAGCAACTAGCAAAGCATTTGAACCCAAT
+CTTCCTAATCACAAATTAGACACAGTTTCAGAAGCTTTAGATATCAACTTATGGCATCAC
+CATAACGCTTTAAGTGACAGTGAAGCTTGCGCAGGAATTTTAATTGAAGAAAATAAACGT
+GTTGGGGATGATCCAATCAAAAAAATGGTTAAGCAAATTTAAGCTTAACCATTTTTTATT
+ATTCAAAAGATTTTTTTATATCTGATAACCAGACTTGGTTTCTCTCACCAACAGTTTTAA
+ATTCAACTATTCGTTTGGTTGAATCCCACGAATCATCAACACGCTTAATCGTTAATTCAA
+GATAATCATTTGGCAGATCATCAATAATAAATTGTGGCCATTCAATTACCACTAATCCAT
+CTTCTGCTAGATATCCAGGCATATCAATACTTGATAAATCACCATCTTCTAGTCGATACA
+TATCCATATGAAAAAGTGGCATTTTACCTTCACGATACTCTCTAACAATTGTAAATGTTG
+GACTTTTTACAGGACGTCTAATACCTAATGACCGAGCAATTCCTTTAGTCAAAGTGGTCT
+TTCCAGCACCTAAATCGCCAGATAAGAGGAGCAGATCATGCCCCTGGCTATTTTTTCCAA
+TTGCCTGGCCTAATTTTTGCATTTGTTCATCAGAATTTATTTCTAATGATTCCATTTTAC
+TTCTCCATATTTGCTTGAGCAGCAGTTAAAATAGCTAACAAGTATACATCTTCTGTTTTA
+CATCCACGTGATAAGTCATTAATTGGAGCAGCTAATCCCTGCAATACAGGTCCAATTGCA
+CTAAAGCCACCTAAACGCTCAGCAACTTTATATGAAATATTACCCGATTGAAGTTCTGGA
+AAAATGAAAACATTAGCATGTCCAGCAACTGCAGAACCTGGAGCTTTTGCTTCTCCTACT
+CGTGGAACAACAGCAGCATCAAACTGTAATTCACCATCGCAAACTAAATCTGGATACTTT
+TGATGTACTAAATCTGTTGCATCTTGAACTTTAGTTACCATCGGTCCCTTTGCTGATCCC
+TTAGTTGAAAAACTAAGCATTGCAATTTTAGGATCAAGCCCAACCATTTCAGCTGTTTTA
+CTGGATTGGTAAGCAATTTCAGCTAATGTCTCACTATCAGGATCAATATTAATTGCACAA
+TCCGCAAATATATATTTTTCGTCTTTGCGTTCCATAATCATAGCGCCAGAAACACGGCTC
+ATTCCTTTTTTAGTTTTAATAATCTGCAAAGCTGGGCGAACCGTATTAGCTGTTGAATGA
+GTAGCACCGGAAACCATTCCGTCAGCCTTTCCTTCATACACTAACATTGTGCCAAAATAT
+GAAACATCTTGTAGAATTTCCTTTGCTTCTGCCAAAGTATTCTTTCCTTTTCTTAATTCA
+ACAAAATCTTGGCACATTTTTTCAAAATCTGAATAGACAGCTGGATTAATTATCTCAATT
+GAACCTAGATCAACATTTAATTTCTCAGCAGATTTTATTACTTCATCAGGTTTTCCTAAC
+AAAAGTGGTTCAACAATTCCCTCTTCTGCGAGACGAACAGCAGCTTTAATTATTCGCTCA
+TCATTTCCTTCAGGAAAAACAATCACTTTTTTTGATTCTTCTGCTTTTTTCTTAAGTGAG
+TCAAATACTTTCATAACAAATTAAGCCTTTCTTTTTATCTCTAGCTAATATTTTACAATT
+TCAATGCTTTTTCTCAAAACAAAAACTATGCCATATCTGATTGACTTACTTCCTGTGGCA
+ATTGCCAATCAATTGGACTCTCACCAAATTTAGTCAAGGCATCATTACATCTAGAAAACG
+GACGAGAGCCAAAGAAACCACGGTCTGCTGAAAAAGGACTAGGGTGTGCAGACTTGATAA
+TTACGTTCTTTTCTTCATCAATTAAAGGAATTTTATTTTGGGCAAATCTTCCCCACAAAA
+TAAATACAACTTTTCCGCGATCACTAAGAGCTTTAATAGCTGCATCAGTGACTATTTCCC
+AGCCTTTTCCCTGATGACCATTAGCATTTCCATAAGGCACTGTTAATACTGCATTAAGCA
+ATAAAACTCCTTGATCCGCCCACTTTTTCAAATAGCCATGATTTACTGGGATGGCACCAA
+CATCATCATATAATTCTTTATAGATATTTTTTAACGATGGTGGCAAAGCAACCCCAGGAT
+TAACGCTGAAACTCATCCCTGTGGCTTGGCCAGGGTTATGGTAAGGATCTTGACCTAAGA
+TCACAACCTTCGTATCTGCAAAAGAAGTTAACTTAAAAGCAGTAAAAATGTGATACATAT
+CTGGAAAAATCTGCTTTGTTCGATATTCACTTTTTAGAAAATCATGTAATTTTTGATACT
+GTTCACTCTCAAAAGCGGGTGCCAAAATTTCATCCCAATCATTTCCAATTAATTTTTTCA
+TATTTATTCTATCCTCTTGTATCTCTAAGAAATCCAAGTTCATGATATCATATAGATAAA
+AGATCGGAGGACTTAAAATGATTAAACTTATTGTAAGCGATATGGATGGCACACTATTAA
+ATAAACAAATGCAGATTTCTTCTGAAAATATTTCTGCTATTAAAGAAGCACAAGCTAAAG
+GAATCGAATTTTTAGTAGCAACTGGACGAGCACCTTCTGAATCTCAAGGAATACTGGCTA
+AAGCTGGACTTCACACTGGCTTCATTAACTTAAATGGCGCAATGGTTTTTAATACAGAAG
+GTAAACTAATTGTAAACGAGCCAATTCCTAAAGAAGAGAG
+>NODE_18_length_37282_cov_67.8523_ID_35
+ACAATCACAGTGCCTGTAGTCTTGCCTGGCTTAGTTACATCTGGAGTCTTCTCCCAAGTG
+TACTTAGTGCCGCTTGGCATATCATCCTTGTTCTTAATGCCCTTTTCTGCTGGTGGTACT
+ACACCTGGGGTAGTGTGAACATCTTGACCTTCTGGGGTGTACTTGTCAGCATCAGTTGGA
+GTTGTAGTCTTAGTGTAAGCAACTACCACATTGGTATTTGGTGTGTTAGCATTTACATTC
+TTATCAGCTAAAACAACTTTTGCATCTTTGCCATCAACGGTTGAAGTATAGTCAGTTACT
+TGTGGCACATTGTATTCTGGCCAAGTGCCTTCAGTTGCTCCAGTTGACTTCCAAGTATTG
+CCATCTTTTACGCCAACAGTCCATGGAGTATCAGCTTCTACATTTTCACCTTCACCGCCA
+CGAACAAAGTGAACAGTTTGAACAATCGTTTCAGTTGTTCCATCAACCTTATTAACAGTA
+ATCGTACGAACAACGTCTTTGTTCATGTCCTTATTATTTGGATCATATGGTGTTGGAGTT
+ACTGTATTACTCTTTTGGTAAGTAATATGAACTGCTTCACCATCTATTCAATTGCGGAAG
+CTGATTGAATTTCAGTTGCTTTAGTGCCATTTACGTATGAATCGTAACTAGAAATTTGTT
+CTACTGCTGCAGTTGGATATTCTGCTTCGCCGCCTAAAACGAACTTGTTGTTTTCGATCT
+TACCAACTTCCCAAGCACCAGTTCCAGTAACTTTTCCAGTTACTAAGTCTTCAACACCGT
+TTCTACCAAAGTTAACAGTTTGAGTTGCAATTAATTGCTCTGCTTTGCCTGGCTTAGTTT
+GGTAAATCTTACGGCTAACGCTAGTAAACATGTCCTTGTACTTGTACTTAGGATCAGTTG
+GATTTACACCTGGAGTTGTTGGAGTAATGTCCTTTGTTTCGTGAACTAAGTTAATAACAA
+CTGCTTCATTCTTAGCAGGAATAACTACATTTTCTGGTAATGTTTGACCTGCAGCTAGCT
+TGTAACCTGCTGGAATGGTTAAGTTAGTCTTTACATTAACGCCTGGCTTACCACTTACAA
+CAATTGGGTTACCAACATTCTTCTTGTCAACAGTGTCATAGAATTGATAACTTACAGTTA
+CATCTGCAACTGGAGTTTCACTTTGTTGGTAAGTAATGTGAACTGCTTCACCATCTACTG
+GCTTGCCGTTTTCAACTGCGGAAGCTGACTGAATTTCAGTTGCTTTAGTTCCATTTACAT
+ATGAATCGTAACCAGAAATTTGTTCTACTGCTGCAGTTGGATATTCTGCTTCGCCGCCTA
+AAACGAACTTGTTGTTTTCGATCTTACCAACTTCCCAAGCACCAGTTCCAGTAACTTTTC
+CAGTTACTAAGTCTTCAACACCGTTTCTACCAAAGTTAACAGTTTGAGTTGCAATTAATT
+GCTCTGCTTTGCCTGGTTTAGTTTGGTAAATCTTACGGCTAACACTTGTAAACATGTCCT
+TGTACTTAGGATCAGTTGGATCTACGCCTGGAGTTGTTGGAGTGATGTCCTTTGTTCCGT
+GAACTAAAGGAACAATGATTGTATTATCTGTTGTTTGATCAACTGGATAAACGAAACTTG
+GATCAACTTTCCAATTGGTTGGAACTTCACTATCAATATCAGCCTTCAAAGTAGAAGCCT
+TTAAGCCTTGATTCTTATTGAAGTTAAAGGTTAACTTGTCTTTGCCATTCTTAGTTTGCA
+TTGGAGTATTAGTTTCAGCATCAATGTACTTAACAATTACAGTTGCATTGTAGTCTGAAT
+CATCATGTTGCTGTTTACTTTGAGTTACTGGAACAACTAAAACTGCAGGTTGACTAGTAA
+TATTGCTTTCAGCCGCTGGATAACTATAGCCATCTACAATACTGTAGTTAGCTGGTAAAT
+TACTGTTAATAATATTCTTTAGTTGCTCAGCACTTAAACTTGAACCCTTGGCAATATTAC
+CAATAGTGTAAGCTGCAACTTCTTTGCCATCATATTGGTAAGAAACTTGTTGGTTAAAGC
+TAGTCTTTTGATCATCTGGCTTACCTGAATTTCCATCTTTTTCAACGTTGATATTAGCCT
+TAACGTCAAGATAAGTACCATCGTTAAACATAATTCTTACAGTACCTGGAATATAGGCTA
+AAACTTCTGGTGCATTAGAATTAGTATTTTGACCATTCCAACCTTCTCTACCAAGGCTAT
+TAACGTTAATTAAAGTACGATATTGTTATTGAGTTAAATCTGAGATATTACTATTTTGCT
+TAAAGTTCAATGTTGAACCTGTAGTAGCACCGTAGAAGTTGAAGTAATTATTTAGCCAAT
+TGTTATATGCATTAACACCTAAACCTAATTTAGAAACAACATCAGCATCGTTAATTTTGA
+AGTTATAACGCCACTTAGAATTTCCTGGTAAACTTTCGCCTGTAGTAGTCTGCTCTGCTG
+GATTTACTTGACCGTTAGCTAATTGATACAAAGTATCAGCTGAACCATTAGCAAAATTAC
+TTACATTAGTGTTTGGTGCAGAAACGCCTGGTAAATTAGTAATCCAAGAATAAGTAAATG
+CACTAGCTGCAAATTTATCGTTCGCATCTTTTTCGTTGACATAGTTCTTACCATCTGTAC
+TTAGCTTATAAGTAGTTATCTTCTTGTAATCACTTGCTGAATTACCAGTACCATTCCAGT
+CACTGTAGAATTTAATAGTACTAATAGCACTATCATTAACCGATGGAGTGAAATCAACAC
+TAGTCTTATGAACACTGGCTACTGGAGCAGTAAAACTAGTCATCGTTTGATCGCCATAAT
+AAGTATTATGCTCATGATCCATACCAGTTACACTAGCTGGAACATTAACAATCTTGCTTG
+AGCCATCTTTGAATGTAACAACAACTGGTACATTAAAGGAACCAAGTTGAGCATTTGAAT
+CTACTGTTTCAGTTACTTTACCTGTTGTTTGGTCAACATCCACGGTAACACCAGTTGGAG
+CTGTGAAAGTTCCAATCCTATAGTTAGAAACTTCATCGTTTGGCATGTCTGCTGGAATTG
+TTGGGTTAACAGAACCAGTATTTTGTCCTGAATCTGGACGTTCAACATTCAAATGTGGAT
+AAGTAATGTGATATTTTTCAGAATCTTTTTCTTCTGTAGTTACATTAATAGAACTTGCTG
+GAATATTAATATCTAGATAAGTATTTTGTCCTTGAGCATCTTTATCATTGAAAGTAATTC
+TAATTACTCCGCCTTGATCTTGAACAGGCTTAGTTTGCCATGCGGTGGACTGAATTTCAC
+TATCTGGAATATTGTTTTGAACTAAAGCCTTAAATTGTGAGCTAGTTAAATCTGAACCAG
+CCAAAATATCAATTGGCTCAGCTAAAGTCTTAGCACCAGCACCTTTAGCATCAATATCAA
+ATGGGTTAGTCTTGTCAGTCTTTCCATCAATAGTGATATCAATTACGTTATTAGCAATAT
+TCTTACCGGCAGCTGTAGCTATTTCTACAACAGTATTAGGTGTATTTTCCCAATCTGCAG
+TGTAATTTGTAATAGTTGTTGGCGTAGTAGCAATTTGGTGATTTTGGTCAATACTGTAAG
+ATTGAACAGATGTAATCATGCCACTGGCAGAAATAACTTGTGAATTGTCACTTGTTTCAT
+GTGCGTTAGCATTAGCACGACTAATTGTTACTACAGTTGCATTATCATTATTCCAAATAA
+CAGTTTGAGTACCTTTAGTTACAACAACTGGTACATTAGCATTTTGCTTGCTGCCATCTG
+CGTATGTAATAGTAACAGGAATGTTGTAAGCGCCCGGTGTAGTGCTAGTTGTAGGAGTTA
+AAGTAACTCTACCTGTTGAAGGATCAATTTTGCTCCAAGTGGGGGTTGCTTCAGTTCCTG
+CAAAATGAGTACCGTCTGGAGTAGTAATTACTTCGCCAATCTTATTAGTAAAGGTTGGAT
+CAGTTGTAGCTGTCTTTCCTTGTTCAACACTAACTGGCTTATATGAAGGAGTATATTGGT
+TATTTGTTTGTAATTCAGAGCCAAATTTTACACCAGAGGCATTCCACCAACTAAAGTGAT
+TAATAAAGCTATTCAAAGCATTGGAAGCTGCAGTTTCAGTTCCTTCAGGCACAACAGAAC
+CATCAGAGAAACTGTTCGAACCCGTCTCAGAAGGATTTGCAGTTAAAATTACTTCGTTAA
+CACCTTTAGCTGGAGTATCAGCATTAACAGAATCAATCATATATTCTGAGCCTGGTTGAT
+TCCAAGCACCATATTGCTTGTGGGAACGAAAGGCATAGGCAAAGTCCCCACCTTGACTAG
+TATTGTTTAAGTACTTGATGTTCCAAGTTACTGGATCACTAGCACCTGCTGGCACCATGG
+TTAATGGAGTATTATAGTTGCTATCAGCTGAATTAATCACAATGTGAGTTTGTTGGTTAG
+CGACATCACCAGCACCATCAGTCTTAATTAAGTAGCCTGGCTTGTTTGCTGCAGTACGTT
+GTAAGTTAACTAACTTAGCATTAGTGAAGTTAATGTAGTTTTGACTACTTGAACCCCACA
+TAGTTAAAATAGCAGGCCAGCCATTTCTATATGAGCCTTTAGTTAAAGTATAGGTATCTG
+GTAAGTAACTTGAATATGAGGAATCTTCCAAATCTAAGCTACCACCATTCACATCAAGAT
+GATAAGTTGCACCAAGTCCGTCCTTTGGTCCCATTGCAAGCAATGGTGAATCAGAATCAG
+TCACTTTAGTTCTAATAATTGAAAGTAAAGCATTTTGACCAACTCTCACCGTGCTATCAG
+CAGTCTTGCCATCATAATCTAAGCCAATAAGAGCAGCTGATCTCCAACCAGTGGTATTCA
+TCTTGCTAGTTGTAACTTTTAATGAAGAATTCTCTTGTAAATCAAGATCGCTAGCATTCA
+TAATTCCCATTGAGGAACCAGAGCCCAACTCCATCGTTACTTTAGCATTAGGCATTAAGC
+GAACAACACCTGAGGTTGCATTATCAATAGTTTGATTTCCTGCACCGGCACCATTAGGAA
+TAGTAATTCCAGCCATGTTAGAAGTATTAGCACTGTTGAAATCAACTGTAGTACCATTAC
+TTACTACAACATTGCCTGAAACGTTAATATTGCTCAAGTTATTTGAAGTACTGTTATTAG
+CAGCTAAAGTCGTTGATCCGTTAAGGAAGTTAACATTATTAGCTTGAATCAAGGCATTCC
+CAGTTGTATTTGAACTAGTTAAATTGCCTTGCAAATTATTCTTACCCTCGAAGTTAACAT
+TAGTACCTTTATTATTAAGGAGTTGACCTGAGTCTTGACTCGTAGTAACGCCGTTAAAGG
+TAATTGCATCATTATTAGCAGCAGAATTCTTAAACCAGAATGGGCCATAACCACTAACAG
+TTTGCAAACTTAGGTCTTTTAAGACTACGTTCCAGCTATGACTAGCAGTGCTTGCTCCTT
+GATCATAGTGCGTATTGTCACCTAAGCTAATGTAGCGATTGCCCATGTCTAAACCATATT
+GATTTTGACCATCAATGGTAACTTGACGCGCACTACCATAATTATTAATTGTTTGGTAAG
+TATTATTACTCAAGTTAGTATTACTAAAGTCAATATTTTGATTTAATTTAATTGTATTTA
+CGTTAGCATCTTGTAATGCATTGATGAATTGAGAATAATCACTAACTGATTGTTCTTGAT
+TATTTGATGTGTTTTGAGCTTGAGTAATTGAGTTTGTCTGAACAGTAGACTTTACTTGCT
+TAGTTGCAGCTGTTTTTGCTACAGCGTTAGTGTTAGTAGTTTGCTTTACAGACTCATTTT
+TATTAGTTTGAACCTTATTATCAGAAACTACCTCTTTCTTTTGTACATTAGTCGTTTCTG
+CAGTTCTATTAGTGTCTAAAGTAATGTTTTGATTATTAGTTTGATTTTTAACTAGGCCTG
+GGGCTTCTTTGGAAGCTTTTGCAGTATTAGTAACATTTACTTGATTTGGATTTAAGGTAT
+CAGCTTTTACGCTTTTACTACCTGCACCAAGACCGAAAATAGTAAAGCCAATTAAAACTG
+AAGCAGCTCCCACTGAAAATTTTCTAATTGAGAAACGCTCTTTTTTATTTTCCATCTTCC
+GAATTTTTTCTTGATAATTATTCTTAGATAACGTTATTGAATCTCCTCCGTCAATTCTAC
+AGACCTTTCAGTGTTAACTATAGTTCTTCTTTTTATAATATTCAAGGATTTAATAACATA
+TATTGTTTAATGCAGAACTATAAATTACGCTCTAAATATCAATAGCAAAAATTAACAGAA
+AATCAATATGCTATTCAGTTATTTTATGCTTAAAATCCTTGTTATAGCATAGTGTTTATA
+CGTATAAGCATTTTATTATTGAATAGACAATTCAAAATAAAATATTGTATTTTCATTTGC
+AAAATATTAATTAATATTAGCCAGGGTATAAACGCCTGTTATTTTAAAACAAAAAAATAA
+AAATAATTAAAAAAGGAGCCGTATACTACACGACTCCCTCTTTAAATCTCTTTATCTACT
+AATACTATCAGCACGGCCTTTATAATCACCGTTTTCAGTTCCGATAATTAATTCTTCGCC
+TTCTTTAATAAAATCTGGAACAGTTACAACTAAACCAGTATCCATCGTTGCAGGTTTACC
+ACCGCCAGCAGCAGTTGCACCCTTGATTTCTGGTTGAGTTTCTTTAACAGTCATCTTTAC
+AGTAGATGGTAAGTTAATTCCGATTAATTTACCTTCATCAGTAAACTTAAGATCAACATC
+AATATTAGGCATCAAGAACTTAGCTTCTGCTGCAAGGTGTTCCTTAGGAATTAGATATTG
+TTCATAAGTATCAGTATCCATAAAGATAAAGTTAGCGTCATCATCATAAAGGTATTGTGC
+CTTCTTTAAAGCAACGTTAACTAACTCCACCTTCTCACTTGGACGCATTGTTTTGTGAAC
+AACAGCTCCACTCATCACGTCACGTAAGTCCATTTGCATAACCGTGTTACCTTTACCAGG
+CTTGTGGTGGTTACTCTTTAGTACTTCAATTAACTTACCATCTTGGCTAAAAATCATACC
+CTTTTTTAATTCGATTGCTTGCATGTTTTCTCCCTAAAATTTTCTAATATACATATCGCT
+GATCTCATGATTACCATACTTTTTAATAATCATATCAGCTCTCTTCTTAGTTGGTTCGAT
+ATAGTCATGTAAATTCTTCAAGTTAACATCACGCCAGACTCTTTTGGCAAAATTATCTGC
+TTGTTCAAGCGGGACGTTAGCCCACTTATAAAAGAAATTATCTGGATTATTGCGATTAAT
+CTCGAGCATTAAATGGTAGCGATCAAGATACCATTTCTCTAAGTCTTCTTCGCTTGCATC
+CAGATAAATTACATAATCAAAAAAGTCACTTGGGGGAGCTTGCCCTTCTGGAGGCACCTC
+CAGCAGGTTAATTCCCTCAACTACCAAGATATCAGGAACGCTGACATACCCCAATTCATT
+AGGCACCAGATCAGAAATTTCCTGCGAGTATAGTCTATATGGTACTCTTTCTTTACCAGC
+TTTAACGCTTGCTAAAAAAGTATAAAAGGCATCCCAGTTAAATGACGATGGGAAGCCCTT
+TTGATCCATTAAGTTTTTAGCTTTAAGTTCTGCATTCGACATTAAAAAACCATCAGCAGA
+AACTTGGGCAATTGTTTTATCTGGTTCAAGGCGTTCGAACAAGCGAGTTATTTTCTTTGC
+AAAAGTAGATTTCCCTACAGCAACAGACCCAGTTACTCCGATGATAAAAGGTATTTTTTG
+CCATTTTTCGTTATAAAAGGTCTGCTTAGTGCGGTAGATTGCATTTTTTTGGCTCATATT
+GTACTGAAGATTTTTCATCATGAAAATCTCCGCACTAAATTCATCGCTTGGAGGGATTAG
+TGTCTGCCACTTTTCAGATGTCAGATGTGTAAATTGCTCTTGCATAAAAAAGCCGCCTTC
+CTTCTGCCTTGTTCCTAGTATTTTTACATTGTTCAGCCTATCATATATATTGAGAGAAAG
+AAAAGAAGATATCTATGAAAAAATTAATTCTTTTTGGTGATTCCCTACTTGCAGGCTATA
+TTGATGGACGCGCAACTAATATTGTAACTCAAGGACTGCAAGAAAAATTACCTAAATTTA
+CAATTATTAATAATTCTGTACCTGGGACAACTACTGAAGAGGCAATTGATTTTTATGAGT
+TACGAATCAAACCTTTTAAGTATGATCTAGTTATTCTGGCCCTAGGCACTAACGACGCCA
+ACATGCAGTTTGGTTTGAGCGCTGGACGATATGCGCATAACTTACAAGTATTGGTCGATT
+TAATTGGGGCTGATAAAACATTATTAATGGGACCTTCCTATACTAATTGGAAAATTGCTC
+AAGATCAAGCTTGGCCTAAAACTTTGCAATTTGAATTAGTTGCTCAAGAATGCCATGTTG
+AAAATAAAATTCCATTCTTAAATTTTGCCAAAGTAATGCGGCAGACTGGTCACCCCAATA
+AACTATTGCAAAAAGATGGTATTCACCTAAATAAAGCAGGAAATAAGTTATTGATTGAAA
+GATTAGCAGACCTAGTTGAAGAAAAAGAATTGGTTACTGCATCGTAAAAAAGCATCCCAT
+TGTTGGGATGCTCTTTTGTACTCCGGATATTTTATTCAGTTACTTCTTGCTTTCTTAATT
+CATTTTGTTCAGCAACTCTAAAGAATGGTAAATAAATAAAAATACCGATAATGATTAAAA
+TCACTTCAAAAATAATATTTCTCCAATCCATTGAACTCATATATGCCTGGAAGAAAAACG
+GTGTAAATGAAGGATCTACAATATACCCCATTCCAATCCAGTGTAAACTTTCAGCAATAT
+AAGTAAGAATAATATTAATAATTGGAGCAATCAAAAATGGAATACCTAAAATAGGATTAA
+AACAAATTGGTGTACCAAAAATTACTGGTTCATTAATACTACAAATTCCAGGAATAATTG
+ATAGCTTACCTAATGCACGATATTTTTCTACTTTGCTTCTCATCATTAGAATTACTAAAG
+CAAGTGAATTACCAGATCCACCTAAAACAGCAATTCTAAACATCTGTAAATTCATTAAAT
+GAGTAGGTGCTAATCCCTTTGCTACTAAAGCAGCATTAGCACCGGTAGCTGCAATACCAG
+TTGCAAAGACAATTGGAAAAATTACATTACTTCCGTTAACACCAATTAACCATAATAGAT
+TTCCTAAAGTTACGATCAAAATATAACCCCATAAGCTATTAGCCAAAAATGTAGCTGGAG
+TCAAACACTTCATAATGAAGGTAGTAAAATCAGCATGCGTTAAGTTGACTAAAATTAAAT
+TAGCACCATAGAAAATAAAGATATTTGCTAATAGCGGTACTAAGGAATTAATAAAGTTGG
+CAACCATTGGGGGAATCGATGCTGGCAACTTTATCTTTAACTTACTCTTTTCAATCCCGC
+GGTCAATTTCGACAGCTAATAATCCAATGATAATTGCAACAAATAGTCCATTTGTTCCTA
+AATTATTGAGACTAATCTTATTATTCTTATCAACAGTAGTTGCAACTATTAAAAAGGTAA
+CTAATGAGATCATCCCATCAGTAGCAGGATGAAGCCTACGATATGACTTACTTAATTCAT
+ATGCAATACCAAAAGCACAAATCATACCAAAGATTCCCATAGTCATATTGTATGGGATAG
+TTATTTGAGCATAATGTGCGACAGCCCAATATTTCCAACCAGCAAGCCATTGCATAAAAA
+TATTAGCTGTTCGTGGATTATATCTATCAAGTACAATTGGTGGGTTAACAACAATTAAGA
+AGAATGAACCAATTACCAAAAATGGCAATCCGAAAAGCATACCATTTGATATAGCTTGTA
+GATGCTTTTCATTTCCAAGTTTTTGTCCAATAGGCGTTAAAACTTTATCCAATTTAGTAA
+TCAGTGAATCTTTTTTAGCAGCAGTTTCAGCCATTAGAGATCACCTATTTTCCTTACTAA
+AGATAAATACAACTTAAATTTGATATGGATTGAACTTGAAAGCATTAGGTATAACTTTAC
+TGTCATCCCAATTTTCTCTAATTTTGTGGTATTCGTCCCAATAGTCATTGTCCACTTTTA
+ATTGTGGAGTAACCTTAGAATCGACTTCTAGAAAATGCATACTTCCTCTTCCCATCTTTT
+TGCCACGAGTGGTGTGCTTGTCTAATGCATAATCTGGAATTTCAGGAACATAACCTAGAG
+CAAAGTTCTTAATAATGATATTCTTAAGTAAATCAGAAGACCGATCCTTAGTTGATTCAC
+ATAAGTAACGAATTGCATGAACAAACATCATGGCACGATCCGGCTCATTGTAACTAAAGT
+TTTGTCTCATTTGATTTAGACTATTAATCAAAATTGGAGCTTGTGGATTTCCCATTCCTA
+TATCTTCAACTGAAATAGCTTGAAGTCTACGCCATAGTTTTTCTTCCATTTGCGGAGAAG
+AAATATACATTTCATAAGCAAATTCACATGCTGCTCGTTCTTTGCCTTTTCTGATTGATT
+TTTGCAATGCAGAGATAACTTCATCAGCTGCTAATCCATTTCTAGTCCTAGTTCTGGCCC
+ATGGATCAGCTAAAAATTCCTTATCTCTATTTTGTGGTACTTCATTTTTCTTAATATCTT
+TTTCTGACATCGTGAGTCCTTCTTTCAATATATAGGAGAAAACAATGAATATTCAAACTA
+TTAGCGAAAAGTTTCAACTGAATACTGATGAACAAAAAATATTAATTTATATGAATCAAC
+ACCGTAATGAAATTAAAAATATCAATATTCGTGAACTCGCTAAACGAACATTTACATCTC
+CTAGCTTTATCGTTAAGACCTGTAAAAAGATGAAGCTTTCAGGATATTCAGAATTGGTCT
+TTCTAATTGCAGATGCGCCAAATTTTCCTAATAATACTGAAAACGACTTAAAAGTAGAGT
+CATACGTAAAGCCTTTTTCCAACTTGATGGATAAGCATAAAGACTCAATGATCATGATAT
+TGGGCAGTGGATACTCTCAAAATATTGCTAATTACATGAGTGAATATCTTAATTTGAATG
+GCTTTCGTTGTACATCCAATTCGCATCTTGAGATGCTTAGAAAGCATAAGAATACTTTAA
+TAATTATCATCAGCAATTCTGGAGAAACAAAGCGATTAGCTGAACTTTGCATACAAGCTC
+AGAAAAATAATCGTGATGTTATTTCCTTTACAGGAGATAAGAACTCAACAATTGCAAAAC
+ACTCAACGCTTGCAATAAGCTCAGATACTTTTAACCCCACTTCTTTTGACAGCCATTACC
+CTCAGCTGTTTTTTGGTCTAACACTCATCTATTTTGAATTATTAATGAGTAACTTTTTGT
+CTAATTAGGTACCTTCTTAAGACAATTCTTATACTACTTTGGTTTTTAACAATTTTGAAT
+ACTTTTCCTTGTTTTGAAAACATGTTTCCATTTTAAAAAACATTTTTATTCAGGCATCAA
+AAAAGGCATCCCTAACGGGATGCTTTTTTTACACACACTACTCTACGTACAAGGCTTGCT
+TACCTTGCTGATTATAGCTAGCCTCTATTTTCTTTAAACTTACTTTTTTATCTTTAACGC
+CATAAGGATCATTTACGTAAACAATCCCCTTCTTTTTATTATATCCAGTAACCACACAAG
+CATGAGAAGAAGGTGTCACATTAACCTTTCCCTGCTTAGTCTGCCATGTCCGCATATCAT
+TTACCCGGTCATATTTTAAAGTCGTAATAATCATTACTGGGTGTCCTTTAGAAACTAACT
+TCAACACCCTAACAAAATCATTGCCAGTATAATTACGAATTCTCTTAGTATACTTCTTAG
+CAACATCATAGAGCGGCTCATTATAAACACACCACCCCGCGTTTTCGATACTCATATAAC
+CAACAAAACCGACATGAGGATTTCCGCGATAATCATTGCCAATAAAAGAGGAAACATGCT
+TAATGTTAGAAGACAATTCTAATTTACTTACATTAATATCATAATAATTTAGGAGCATTG
+ACAGTGACGTAACTTCACAGCCATTTGGCAGGTCCGGTAATTGCCTTTCTAAGGGGACAT
+TCAATTTTTGCTCAGGTCTTAAAGTAAGCCAGTCATATTCATTTTGAATTTTTTCAAAAT
+TAAGGATAATCCCAACTACTCCAGCTGTAATCAGTATTAAAATTCCATATAAAATCTTTC
+GTCGACGTCGATATCTCTTTGCTCTGCTTATTCTTTTCATGCTGAATATTCTATATCAGA
+AATGTCAAAACGCAAATTAAGTTGGCAATGTAAGAATTAAATAGATTTCATTTCTTTTGT
+GCTTTTAGCATAAGAATTAAATTAACTTTATTTATACTCGAAATATGGAACAAGAATTAA
+GTTAATTTAATTTATATGCTAAAATTAAATTAAGAATTAAATTAGTTAAAATCTTGTATC
+AACTATTATTAAAATTAGAGGTTAACAATGGTACCACGTGATTCTTACTTAAATATTTTA
+GATAAACTACGTAATAAACAAATCATTAAAGTCCTAACTGGAGTACGTCGCTGCGGTAAA
+TCTACTATTCTTCAGTTATATCAAGAGCGATTGCTCAAGTCTGGAGTAAATACTAATCAA
+ATTCAAACGATAAATTTTGAAGATTTAGACTTAGTATCAATTAAGACCTACCTAGACCTA
+TATAACTACATCAATGAACATCTCATTCCTAACAAAATGAATTACATCTTTATTGATGAA
+ATCCAAAGCATTCCTAATTTTGAAAAAGCACTCGATAGTCTTTATATAAAAAATAATGTA
+GATTTATATGTCACAGGATCTAATGCCTTTATGCTTTCTGGCGAATTAGCTACTCTTCTT
+TCGGGACGCTACATAGAAATCCCTATCTATCCTTTTTCTTTTAAAGAATTTTTACAAACA
+ACTGAACTTTCAAAAGAAGAAGCCTTTTCAACTTACTTAGAACGAGGTGGATTTCCATTT
+GCTACTGAATTAAACGACAATAATACTTATCTTTCTTACATTCAAGGAATTATCAATACA
+GTATTAATAAAAGATATCCTAACGAGAGTGAATCGCGGTAATGCAACTTTACTTGAAGCA
+ATTGCTAGTTTCTTAACTGAAGCCAACGGCAGTCTCGTTACTCCTGCTAAAATTGCCAAT
+ACTCTAACCTCTAATGGAATCAAGACTAGCAACGCCACAGTAATTTCATACCTCGAAAAA
+TTAGTAAATTCCTATTTATTCTACCAATGCAATCGATATGATATTGCAGGCAAAAAATAT
+CTACAAATTAATAGCAAGTATTACCCCGTTGACCCCGCCCTCAGACGTGCTCTTTTAGGT
+CAGAAACGTCCAAACATGGGCAGCAGGCTTGAAAATATCGTGTTTATGGAATTAAAGAGA
+CGCGGTTATGAAGTATATGTCGGTAGTCTTAAAAATAAAGAAATTGATTTCGTTGCAATC
+AAAGACGGTGTTAAGCAATATTATCAAGTTAGTCTCACAGTCCAAGACGATAAGACTTAT
+AATAGGGAAATTGCGCCCTTTCTTGAAATTACTGATAACTATCGGAAAATTCTTCTCACT
+CAAGACCCCGGTAGCTACAACGACAATGGTATTGAACAAATAAACGTTATCGACTGGCTA
+CTAAAAGAGCAATAAATTTAAATAAACCCACAAAAAATGGAATGCCAAATTTGGCACTCC
+ATTTTTTTATTTATTCACATAAGTCTTCTCGTCTAAATCATCAAACAGTGGGCTCTTCTC
+GCCTGTATAAATCAAGTCAAGTTTATACATTGCACGTGAAGTAATTGTGTAAAGCAATTG
+CGTTTCATCAAGTTGGTGATAATTATCCCTTGAAACATTCCAAGCAATTACTGCATCAAA
+TTCAAGGCCTTTAGCTAAATATGATGGCATAACTAAAGTTCCAGGCACTAAACGCTGGTT
+AGCTGACCCAATTAAAGTTGCCTTAATTTTTCTTTCTTTCAAAACCTTAGCCACTTCTTT
+TGCTTCAGCCAAAGTCTTAGTAATAATGGCAGTAGTTAACTTTTGCTCATCATTTTCTAC
+TAAGATATCTTCTAAAGCATTATATTCTTTTTCAAGACTGTCACGCTTGTAAAAAGCAGG
+CTTAGGACCACGTCTATCAAAGGCCTCAATCTTTTCACCTTGCCGCAGAATTTGCTTAGT
+AAAATTAGTTAATTCCTTAGTTGAACGATAAGACTTGGTTAATTGAACAACATCAGTCTT
+TTCAGGATCAAACAACTTGGAAATCTGACCTAAAAGAGTCTTACTTTCATCTTTAGTAAA
+AATAGCCTGGTTCAAATCTCCGAGCATCGTAAATTTAGCTCTTGGGAAGTTGTATTTAAG
+GTAAGCTAACTGGAATGGAGTGTAATCTTGAATTTCATCAATAAAGGCATAACGCATTTC
+ATAGTCAGTTCTACGCCCTGTAACTAAATCGTACAAGTACAAATATGGTGAAATATCAGC
+CATCTTGATCTTGCCGTTTCTGAACCTATCTTTAACATTTTCAATATGTGCTTCCCACTC
+TTCTTGGCTAATCTCCCACTTGCTTAAATCAATCAACTTAGGAACAGCACGCAAGAAGCG
+CAAGTATTGCGCACGAATATTCAAGAAACGGTTCTGATGAATCTTACGACTAACTTGCTT
+TAATTGCTTAATTACAATTTTACGAGCTAAGAAGTGCTCTTCTTTAGCACTTGATTCAAA
+TTCTTGGTCTGGACGATCATATAACTTATTCAATTGCTCTTGATCTAACGATTCAATCGT
+CTTATCAACCCAAGCCTTCTTAGTTTCTGGCTCAATTCTTCTATTTAAGCTATTAATTAA
+AGCTTCTTTGGTAGCTTCAATTCTGTTTCTTAAATGGTAATTTTCATTAAAACCATAGTA
+AATTTCCTTGATCTTTTCTTTATCAAAAAATGGTTTCTTCTTATTCTTGAAATAAATATT
+TTTAAAAATTAAACCATTCTTTTCAAGGTGCTTAGCATAGCGAGTTACCGCATTAAAGAA
+TTGTAAGGAATCTTTTAAGTTAACGATCTTGTCATTTTGCTCATTATCTTCGAATTGTTC
+AAATAAGTTTTCAACATTCATCCCTGGAACACGACGAGAAACAAATTGCCAGTAAGTCAT
+CTGCACCATATTTTGTTCACCCATTTCAGGTAGAACATTTTTAACATAATCGTTAAACAA
+TTGATTAGGGCTAAACATAATAACATCGCTAGAAGTTAAATTCCCGTGATAACGGTAAAG
+TAGGTACGCCACACGTTGCATAATAGCTGAGGTCTTACCTGATCCTGCTGCCCCTTGAAC
+AAATAAAAGATCTGCACTAGTATTTCTAATAATCTTATTTTGCTCACGCTGAATCGTTGT
+TACGATCGACTTCATCTGTGTAGAAGATTTTTCGTTTAAGACATTTAAGAGCATTTGATC
+CCCAATTGATTCATTGGTATCAAACATATTGGTAATCTTACCATCTTCAATTAAGAATTG
+CCGTTTCTTAGTCATATCAACGGTTTGCACACCATCGGGCGCATTATAAGAAACTTTACC
+TAACTTACCATCATAATAAATAGAAGATATCGGTGCACGCCAATCATAGATTAAAAAATG
+ATCTTCTTTATCTGCAAAAGACCCTAAGCCAATATAAATCGTTTCAGGATCTTCATTAGG
+TTCTTGGAAATCAACTCTGGCAAAGTACGGTCTCTTTTCTAGACGCTGCAAAGTTGATAA
+TTGCTTAGCAGAATGTTGCCAGGCATTTTGACGTTCTGCTGACATTTGTTGCTGCTGATG
+AATTGACAAGGCAGTATCCATTGAAGTTGAATAGCCATCATAATCTAATTTCACATCATC
+AAAAAAGTGCGAATTAATATTTTGCGCTTCATTTTGCGCATGTTCAATTGAATGATCTAA
+TTCGCTTTCTTTCTTTTTAATTAAGCCTAGAACTTTATCTAAATGTTTTTGTTCTTTTTG
+TTGTTCAGTTTCTTTTACCAAAATTAAGTCACCTATTTCTAGTATTAGTAAAAACTTTGC
+ATACTATTTTATCATATGTATACGCTTTCTAAAAGGATTTACAACTTTGAGAAAGTCTCA
+ATTATTATTTAGTCTTTTCTTAATTAATTAGTTTTATAATTAAATAAAATTACCTAGCGA
+GATGAAAAAGTGAAACGATTCTTTAAAAGTATTCTAGTTCTAGCTCTTTTATTTATTGGA
+CTTAACTTTGCTTATCAAAAGACTGCGCCAGAAATTGAAAAAACTTTTGGAACTAGAAAC
+CCACTCCCATATTTAACAGCCAAAGTACAACAATTTATTTCACCTGAAAAAATTCAAAAT
+GATGATACAAATGCCGACAGTTCCAAAGGACATACTTTTGAAACTAACTCTGCATCTGTT
+TATCTTGACCTCTCTGATCCCACCCTCAGGCAAGCCGCAATTGATGGAATCAATATTTGG
+AACAATACAGGGGCCTTTAATTTCAAAATTACGAATAACAAAAATAATGCCAAAATCATC
+ATTAAAGCAATGAATGATGGACAGACTAACGCGGCTGGTTTAACTGATACGCAATATAAT
+TCCCTAACAGGGCACTTAATTAAAGCAACTGTCCGTTTAAATTCATATTACCTTTTAAAA
+TCCAAGTTATGGCTACAACCACGGTCGAATCGTCAACACAGTTGAACACGAATTAGGCCA
+TGCAATCGGGTTAGGCCATAAGAACGGCATTTCCGTCATGTATCCACAAGGATCTTTCTA
+TACCATTCAGCCAAGCGATGTTGAAGATGTTAAAAAATTATATCAAGAACAATAAGAGCG
+ATTCTATTTTTAAGAACCGCTCTTATTTTGTATTTTTCTTTTTTAATTGGTGTTGCTTTT
+TAAAATAAGGAATCCAGAAAGTTATGACATAACCTACTGCAATACCTACAAAAGTCCATA
+CCATAATATTTTTAACAAATAAACCGATAAACAAACCAATTAAGCCAAAAATCCCAATAA
+TAAATGATTGATCTAGTTGCTTCATACTTATTTCTCCATTTCTATCTTAACTATAACAAA
+ATTATCTTATTATAAGCATATTTTTAGACTTACTTTGCCTTGCATTTTATACTATATATC
+ATAAATGTTTTTAGATATATTTGCTTATATGCAAACAAATATCAACACTATACAAATAAA
+GAAATGTATTTTAATAAAAGAAAGGAATGGTATATCCTTTATGGATAATCAGAAACAACC
+TCCCTCGTATTCTCAAACAACAAACGAGTTATTTTCAGATTTAGAAACAAGTTCTACTGG
+CTTAAGTGAGCCAGAAGCTCAGCGGCGGTTAAAGAAATATGGACCTAACGCTCTAGCTGA
+AAAGCCACCAAAATCAACCTTAATGATGCTCAAAGAGCAAATCATTGATCCGATGATTTT
+GATCTTATTAGGAGCAGCTGCTTTTTCTGCAATTTTAAATGAATGGGTAGAAGCCAGCGT
+AATTTTCTTTATTGTTGTCGTTAACTCAATTATTGGAATTATTCAGGAGAAAAAAGCTCA
+GTCTTCTCTAGCGGCTCTCAAAACGATGAGCGCGCCAACTGCTACAGTTATGCGTGGCGG
+TATTGAAAAGATCATCCCTGCTAGCGAATTAGTTATCGGGGATTTAGTTATTCTAGCTAG
+TGGCGACATGGTTCCAGCTGATTTGCGTTTAATTCAATCTGCTAACTTAAAAATTGCAGA
+AGCCTCTTTAACCGGTGAATCAATTGCTAGTGAAAAGAATGCGAAAGCTGTTCTTTCAGT
+AGATTGTCCTCTAGGCGACAGAAAGAATATGGCTTATACTTCTTCAATCGTTACTTACGG
+ACGAGGAAGCGGGATTGTAACTAAAACTGGAATGGACACCGAAATTGGCCAAATAGCCGG
+TATGCTTGAAAATGATGATGCTGGTGATACTCCATTAAAGCGAAAACTTAATACAGTAGG
+TAAAGTCTTAACAATCATTGGCTTAATTATCTGCGTTTTAATCTTTGCAATTGGTGCCTT
+TTACGGCCGCCCACTTTTACCCCAATTTTTAGTAGCAATTTCTTTAGCAATTTCAATTAT
+TCCAGAAGGTCTACCAGCAACTGCAACCATTATTATGGCGCTAGGCGTGCAACGAATGGC
+AAAACAACATGCCTTAATTAAGAAGTTGCCTGCTGTTGAAACTCTAGGAAACGCGACGGT
+TATTTGTTCTGATAAGACAGGAACATTAACGTTAAATAAAATGACTGTAACTCATTTAGC
+TAATGGTGATGATTTCCTTAATAAAAAAGTTCTAAGTGTAGAAAAAGCAAGTAAGGATTC
+TAATTCATATAAGCAATTAATCTATGCATCTAGTCTTTGTAACGATGCTAGTTTTAATTT
+AGAAAATCCTAAAGAAGTAATTGGAGACCCGACTGAAGGTGCACTTCTTCCTCTAGCACA
+AGATTTAGGTTACTCGGCTCTTAACTTAAGAAAAGAGTATCCAAGACTTAGCGAATATCC
+TTTCGATTCAATTAGAAAGAGAATGACTACGGTTCATGAAATAAACAATGAATACGTCGC
+TTACACTAAAGGTGCGCTCGATGAGTTACTGCCACTTTGTGACTACATCTACACAAATAA
+TGGTATGCGTAAATTAACTAAGTCAGATAAAGATAATATTCTTACCTTATCGCACAAGAT
+GTCTGATCAAGCATTAAGAGTCTTAGGCTTTGCCAGCAAAAATATGCTAAACCTGCCTCA
+AGAAGGAGAAAATATTGAACAGCATTTAGTTTTCTTAGGTACAGTCGGTATGATTGATCC
+TGCCAGAGATGAGGTTAAGGCATCAATTAAGATGGCTCGCGAAGCTGGAATTAAGACCAT
+TATGATCACGGGTGACCACAAAAATACAGCAGTCGCTATTGCTAAAAATTTAGGTATTTA
+TACTAATGGAAACACTGTTATTTCAGGTACTGAATTAAACGAAATGACAGATAATGAACT
+AGATCAAGCAGTTAAATCCGCCACTGTTTTTGCCCGCGTTTCGCCTAATGATAAATTAAG
+AATCATTCAAAGCCTAAAACGAAATAATGAAGTAGTAGCCATGACAGGAGATGGGGTCAA
+TGACTCACCCACCCTAAAGGCTGCTGATATCGGTGTTGCTATGGGTATTGGTGGTACTGA
+TGTTGCTAAAGATGTTTCAGATATGATTTTACTTAATGATAGCTTTACAACAATTACGGC
+AGCAATTAGAGAAGGTCGAAAAGTATATCGCAATATTCAGAAAGTAATTCAATTTTTACT
+AGTTGGTAATATTGCCGAAATTACTACTTTATTTGTAGCTACAATCTTCAACTGGGATGC
+ACCGCTACTTGCTGTGCATATTCTCTGGGTTAACTTAGCTACAGCTAGTTTGCCTGCTTT
+AGCTTTAGGAGTAGACCCAGCAAGTAAAAATATCATGAAACATAAGCCAGTAAAGACTGG
+AACTTTGTTTGAAAAAGACCTTGTTTGGCGTGTTATCAGTCAAGGAATTTTCGTCGCCTT
+AATGACCTTAATAGCTTACTGGATTGGAGAGTCGTTTGATAATCCAATTGCTGGTCAAAC
+AATGGCATTTTGCGTTTTAGCCTTATCCCAAATGCTTCGCGCATTTAACCAACATTCTAA
+TACTGATCCAATCTGGGTTAGAGGCAATAAAATAAATGTTTGGTTGATTATCTCCTTTAT
+TGTTTCAGCGGTCCTAATGGGAATCATTCTTTTCACTCCTAACTTACAAACTCTCTTCCA
+TTTGACTAGTCTTACTTCAAGACAATGGTTAGTAGTAATTATTCTTTCTCTCTTCTCTAT
+CCTGCAAGTTGAGATAAGCAAGTGGATTAAGAAGCTAATTAAAGCTAGACAAAAAGAAAA
+CAAGCTGCAAACAACCAGTGACTAACATAATATAATAATTTAATTATTATGAGCATATTT
+TTCGACTTATGATGATTTAATTTATATAATATAAGTATAAATTTAACACTTACATCTGGC
+ATAAAGACTTAAACAACCTTTATGCCTTCCACTTTTTGGTAATCAAAATAATCGGTATCG
+TAGATACCAAAACAGCCAAATTGTAGTGACCCCCGAACTTCGGACACGGATTCATCCTTA
+CACAAACTATTTTACGGTCTCAAAGAAAGAGCTTTCAATGTCTATATACAATATTTTATA
+TACTGTTTTAGCATAATATATATTTATGGAATATTATTTTTTTAAGATTAATTGTTGACT
+AAAAGTAAGTTATAGGATATTATAACTTGTGAAAAGTAAGAAAGGAGCTAATGATTATGT
+TTAATGTACGTCAAGCAAATTCTTGTTGTTGTAATTGTCAAAAAATTTGGCAATTATTTG
+GCGTACAGTCATTAGTTCACTTCAGGAATTTCTCTAGTTAGAAACTAGCTTTTCAAAGTT
+ATAACTATGATTTTTCTCAAGAGCTGTTGGCACTAGGCCAATGGCTCTTTTTTGTTTGCT
+TAGAATCGGGGTTGAATAAATTGCAAACTACTCTCATTGTTTTAGTAGCCGTCGCTATTC
+TAGCTGGCATGGCTTACTTACATAAAAAGAATTGGGGATTTACCAAGCTAGTATTTCTCT
+CATTAGTCGTTGGAATCGTCTTTGGAGTTTCTATTCAATTAATGTTTGGTGCCAAAAACG
+AGATTGTAAAAAATAGTATTGATTGGATTTCCATTGTTGGAGATGGGTATGTCTCCTTAT
+TACAAATGTTGGTTATCCCACTTCATTAGTTGGTGCCTTTACGCAATTAAAAATGACTAC
+TAAAATCCGAAAAATTGCTACAAGTGTCTTAGCTATCTTGCTAGGAACTACTGCAGTTGC
+TTCATTCCTGGGCTTTAGCAGTGTTGCAATTTTTAATTTAGGCGGAGCTGGCTTTGCTAA
+GGGAATGACTGCTTCTTCAACTGCTCTTAGTGCAATTAAGGACCATCAAGAACAATTGAA
+AGGCCTAACTTTACCGCAACAAATTACTTCGTTTTTCCCGCAAAATATTTTTGCCGACTT
+TGCAGGAATGCGTTCAACTAGTACAATTGCAGTTGTAGTTTTCTCTATCTTTGTCGGAAT
+TGCATTCTTACAAATTAAGAAAGAAAAAGCTGAAGTCGCTGCTACCTTTGCACGTGGTAT
+TCAAGCATTACGTGCAATTATCATGCGGATAGTTAAAATTGTACTCGAACTCACTCCATA
+CGGAATCTTTGCTCTAATTGCTAGAACTACTGCAACTAACAGTTTCGCAACAATGAGCAA
+ATTATTGGTCTTCATCGTTGCCGCTTATGTTGCAATAATAGTTATGTTTATTGTTCACGC
+TGTTTTACTTTTAATTAATGGAATTAATCCTATTACTTACTTTAAGAAGGCGTGGCCAGT
+TTTAGTTTTTGACTTCACTTCCAGAACTAGTGGTGGTAGTTTGCCACTTAATGTTCGTAC
+TCAACGTGAATCAATGGGCGTTAGCGACACAATTGCCGATTTCGCCGCTAGCTTTGGTTT
+AACTATTGGTCAAAATGGATGTGCAGGTATTTACCCATCGATGGTTGCAGCAATTACTGC
+TCCCCTTGTTGGAGTTAATATTTTCTCATGGCAATTTGTCTTAACCTTAGTTGTAATTGA
+TGTTATTTCAAGTTTCGGCGTTGCCGGTGTTGGTGGCGGTGCAACATTTACTACTTTAAT
+GGTACTTGGAGCACTTAACCTGCCAGTTACAGTACTTGGAGTTTTAATTGCTATTGACCC
+AATCGTTGACATGGCAAGAACTGCTCTTAATGTTAATGATTCGATGGTCGCTGGTGTAAT
+TACTGCTAAGCGTACTGGTGAATTAGATTGGAATATCTTTAATAATCAAAAAGATGATGT
+AGATACTGAAATTGAATAATTTTTATAAATATTCTTGACATTATTATTTAGTCATTGTAG
+TATTATGACAACAAAATTAATTAAAGCTTAGAAAAGATGAGTAAGCACTTAATGCATCTC
+ACAGAGAGTCGGAACAGGTGTAAGCCGATGTTGCTAGAGTGAAGAAGATGGTCTTGGAGC
+TAAATTAAAATGCGAGCTATTTAAAGTAAGCAATTTACGATTGACGTACGTTATCACGTC
+TGAGTCTTCCATATTTTGGAGTACTTATTAAGGAACTGATTGTGAAATCGGTTTGAATAT
+AGGGTGGTAACACGGTATTAAGCGTCCCTAGTGTAGTGTAATAGCTATACTAAGGACGCT
+TTTTCTTTTGCCGATTTTTTTTTGTCAAAGGAGGGATCATTATGAAAAATAAGAATATTA
+TTTTTAACGAACGGGTATTTAATCGAATGTGCTACTTAAATATGATCCTTCTTGTTAGTG
+GATCCTCAAAAAACATTTAAGTGAAAAATTTAGTTAAAATTAAGAGGTAGATTACTATGA
+CAGAATTAGCACATTTCGACATTGTTGGTAGTTTTTTAAGACCGGAAGAATTAAAACAGG
+CTAGAGATAAATTTAATCACGGAGATATTTCGCAAGCTGAACTAATTCAAGTAGAAAACC
+AAGATATTGAAAAGTTAATTCATACAGAAGAAAACTTAGGCTTAAAAGCTGTAACTGATG
+GCGAATTTCGTCGCAGTTGGTGGCATCTTGAATTTTTATGGGGTTTAACTGGCGTTAAAA
+AATATGATTATCACGAAAGCTACAAGTTCCATGGCGCTAAAACTAGAACAGATAATGCAG
+AATTAGCTGGCAAAGTAGCTTATAATCCCGAGCATCCATTCTTTAAAGCGTTTGAGTTTG
+TTAAAGAGCATACTAATGTGACTCCTAAACAAACTATCCCATCCCCTACACTGCTTTTTA
+GAGATAACCGATCAGATAATTGGCCTAATTTTTATAATAATAAACGAGCTTATCTTGATG
+ATCTGGCTAAAGCGTACCATGAAACAATCAAGCATTTTTACGACTTAGGTTGTTGCTATC
+TTCAAATTGATGACACAACTTGGGCTTTTTTAATCAGTAAATTGAACGAATCCAAAAATG
+ATCCCAAGGAACATGAAAAATATATTCAATTAGCGGAAGATTCAGTGTATGTAATTAATA
+AGTCACTAGAAAATCTACCAGATGATCTGACTGTTGCTACACATATTTGTCGTGGTAATT
+TTAAATCTACATTTCTTTTTTCAGGCGGATATGAACCAATTGCTAAGTATTTGGCGCAAT
+TAAATTATAATCGCTTTTTCTTAGAATACGACAATGACCGTGCTGGAGATTTTGCTCCAA
+TTAAAACAATCTGGAACAACCGGGATGACGTCACAATTGTTTTAGGATTAATTACATCAA
+AAGATGGACAGTTAGAAAATCCTGCTGCAATTATTCAAAGAGTTAATGAAGCAGCTAAAT
+TAGTTCCATTGTCTAACCTCGCGCTTAGTACGCAATGCGGCTTTGCCTCAACAGAAGAAG
+GTAATATTCTCAGCGAAGCTGATCAATGGAAAAAGATAAAATTAGTCGTTGATACTGCTA
+ACAAAATTTGGAAATAAAAGATATTTTTATAAGGAGGAAATTTATTATGGGTAAAGTTGA
+AAGTTTTGAATTAGATCACACTAAAGTTAAGGCACCTTATGTTCGCCTAATTACTGTTGA
+AGAAGGTAAAAAAGGTGACAAGATTAGTAATTTTGATCTTCGCTTAGTTCAGCCAAATGA
+AAATGCCATCCCTACTGGAGGCTTACATACTATCGAGCACTTGTTAGCTGGATTATTGCG
+TGACCGTATTGACGGCTACATTGATTGTTCACCATTTGGTTGCCGAACGGGCTTTCATCT
+TTTGGTTTGGGGTACCCCATCAACTACAGATGTTGCTAAGTCTCTTAAGGAAGCACTTGA
+AGAAATTCGCGATAATATTCAATGGGAGGATGTTCCTGGCACTACTATTGAATCTTGTGG
+GAATTATCGCGACCATTCTCTATTTTCTGCTAAACAATGGTCAAGAGATATTTTAGAAAA
+GGGTATTTCTGATGATCCATTTGAAAGAAACGTTGTAGAATAATTATTTTTGAAAAATAG
+GACAAAAAAGATGCATATTACTGCTTCAAACAGTAAAAATGCATCTTTTTTCGTATTTAT
+TTAATTTTTATCTTTTTCTTCTCTTCCTTTCTTTACCACCAATTAGTCCAATTATTGCTC
+CGACAGAAGCTAATGCTAATCCTGCTAATGATAAATCTGTCTTTTGACTACCAGTTTGCG
+GTAGTGTTGTTCTAGCACGATTAATTTGCTTAGCTGATGTGACATTTCTTGAAGTTCCAA
+CTGCATAAGTTGTATGAGTTAAGCTTGTAGAAGTGTTTGAAGCTTCAACATTCTTGGACT
+TGTTTAACTTATTAATTTGCGTAACAATCTTAGATGATTCTGTTTCATTCGATTGATTTG
+GCTTGTTAGGTATTGTTTGTTCTTCCGGCTTTGTTGGTTCACTCGGTTGTGCTGGCTTAC
+CTGGTGTTGTCGGTTCTTCCGGCTTCGTTAATTATTCTTTTTATATCTCTTCCACAAGAC
+TATATTCCAAATTATCAACAAGCACACCCAAAAGATGGCTAAAATCATCGTATTCCGATA
+ACCACTGCCTTTTTGAATCTTATTCCAAATTTCGCTAAAGTATGTTCCACTTAAAAATGC
+ACTTAAAGTTATTATCGATAAAGTCAAAGACATCTTTTTAATTTTATCCTTAACCTTCAT
+CAACTGAATCCAGTTATAGACAACTTCACAAATTACGATTAGTAAAACTAGTAAGTCATA
+CCACCATTCACGTTGTTTAACAAATTCATCAATGGTAGTAATAAAATAGTAACCTGCAAG
+GATTGCAAATATGTTTAAGATCAACAGCTGTCCCACAACTGTACTTTGTTCTTTTTCTTT
+CATGATCTTCCGCACTTTCTACTTTTTCTCTTCATATAAATTATAAAACATTCGCTTTTT
+TTCTTGCTTAACCTAAGGCTCTATTTTTTAAACTGCCGCCAATAATTAGCAAGGTATTCT
+GTTGTTAAACTCACGGGATGGTTAATCAAATCTTGTGTTTGTCCTGCAGCAACGACTTTT
+CCACCATTTTTTCCGCCACGTGGCCCTAAATCAAGAATATTATCTGCATTAACTATCATA
+TTTAGATCGTGCGTAATCGTAATAATAGTTGCCCCTTGATCTAGCAATTTCTGCATTACT
+TGAACTAAAACTTTCACATCAAGCGGATGTAATCCAATTGTAGGCTCATCAAATACAAAT
+AAAGTATCGTCCTGTTTATGACTTAAATGTGTCACTAACTTCAAACGCTGTGCCTCTCCA
+CCAGATAAAGTTGGTGTACTTTCACCTAAATGAAGATAATCTAGTCCAACTTCTTTTAGT
+AAAAGTAAGTCACGCTCAATTTTAGGTTCTTTCTTAAAAACAGGAATTGCTTCATTAATA
+TCTAAATTTAAAATATCAACAATTGAGTAGCCGTTCCACTTTACTTTTTGAACTTCTGGA
+TTATAGCGATTACCCTCACAGGTCGGACAAATCTGCTGCATATCAGGTAAAAATTGAATA
+TCTAAAGTTACAATTCCAGTTCCACCACAAGTTGGACAAGCTCCCTGTTTATTATTATAA
+GAAAAGTAAGTTGGCGTATAATGCTTGTTTTTTGCAAGAGGCTGCCGAGCAAATAATTTA
+CGTAAATTATCCATAATTGAAGTATATGTAGCAACAGTTGACCTGGTACTTTTACCAATT
+GGTGAAGCATCAACGCTAACTACTTGATTAATTGGCGATTCAAAGTTCTTAACTTGTTTA
+GGTAAATTTTCACCTTTTGCTTGTGCTTGAATTGCTGGAACTAAACTATCTAGAATTAAA
+CTTGTCTTACCTGCTCCAGAAAATCCAGTCACAGCAGTTAATTGATTAACAGGAATATTC
+GCATGAACATCTTGCAGATTAAAATAATGATCCACATTAAATGAAATTTTTACAGAGTTA
+ACTTTTTCTGCTCGCTTTCTCGCCATTAATTCAGCAGTTCCATCAAGATAAGGTCTAATT
+AAAGATTGCTTGTCTTTTTTTATTTGATCAACGCTACCTTGATCCAGAATTTCACCGCCT
+TGTTCACCTGATCCTGGTCCAATCTCAATTATTTCATCAGCTGCTTTAATAATATCCACA
+TTGTGATCCACAACTACTAGTGAATTTCCTTGTGCTACTAATTTATGCAAGACCTTAATT
+AAGCCGTCAACATTAGCAGGATGTAGCCCAATTGAAGGTTCATCTAAGACATATAAGACG
+CCAGTTGTTTCTGTTCTCAACGTGCGTGCTAACTGAATTCGCTGTAATTCACCTGTGGAT
+AAGGTGTTACCATTTCGAGCCATTGTTAAATAATCTAAGCCTAAATCAAGTAGTGGTTGC
+AAGTTCTCCACAAACTCTGTGAATAAGGCGCTGGCCATTTTATGCATCTCAGCTGGTAAA
+CTCTTAAGCACTTGACCTTTCCAAGCAATCAAATCATCTAACGGCATTTCAGCTACTTCG
+TTAATATTTAAACTACCTACTAATTGCTTCAATAATCCTGGCTTTAATCTTGAACCATGA
+CACACAGGACAAGTCTGATATGAGAAAAATTCTGAAATCCGCTTTTGCGCACGTTCGCTC
+TTACTAGTTTTGGCAGAACGTAAAACAGCTTGGTGAGCATTTTCATAAAGGGCATTAAAA
+TCATGAAAAACTCTCCCCGTTCCTGATAAAAAGTCCATTTTATACTTCTTTTCAGGACCA
+TTAAGAACAAAATCTTTTTCTTTATCAGTTAAATCCTTATAGGGAATGTCAATCCTAACC
+CCCGCATGTTCTGCTACATTGGGCATAAAGTTTCTACCAGGTAGCGACCACGAAGCAACT
+GCTCCCTCTTTAATAGAAAGACTAGGATCAGCAATAAACTTACTATCATCCAATTGACGT
+ACTTTTCCTGTCCCGCCACATTCTTCACAAGCTCCATCAGAATTAAAGGCAAATTGCTCA
+GCACTTGGCACATAAAACTTAACACCGCAAACTGGACAAGTAAGTTGACCCATTTCTTCA
+CCTGACTTTGCCATTGCTTCTGCAATTTCTAGACTTGGCTTTAAACGGTGACCATTAGGA
+CAAACAGGCGAGCCTAATCTAGAAAAGATCAACCGCAAAATATTAAAAGTTTCGCTCATT
+GTTCCAACCGTTGCTCGTTCAGATGGAATAGTTGGACGCTGTCTTAAGGCTAAAGCTGAA
+GGAATATGCTTGACGCTAGTAACATTTGCCTGATTTCCCTGTTTGATTCGTCTACGCATA
+TAAGTAGACAAGGCATCTAAATATCTTCTGGAGCCTTCTTCATATAAGATACCCATGGCT
+AAAGAAGATTTTCCTGAGCCTGACAAACCAGAGATTGCAACAAATTTATGAAGTGGGATA
+TTAACATCAATATTTTTCAGATTATGAACACGTCCCCCACGCACTTCAATCTGAGTTGGT
+AACTTTGCAGTCAAAGTCAGTTCCTCCTTACTTTTTATCAACTACTATCTTACAACAATT
+ATTATAAAAAATAGCCATTCTATCGTTGCCTATACAAAAAGAAGACTCTGCTTTATAAAA
+GTAGAGTCTTCTGAAGGAATATAACTATGAAAATTTAATTTAAGGAAATATTATTTAAGA
+ATTGTGTAATTTGTGTTGATATATGAGGATTATGGAAAATTAAAATTTTAAGTTATTTTG
+TAAAGCCAACATCGTACCATGAGTTTGCTGATGGCTTAAGTGACCAGCCAGTTACCTTGT
+CGTTAACTGCAGTTACTGACCAGCTGTTTGTAGTAAGTACAACGTAGGCATTGTCATACA
+TCCATTGTTGCCACTTATCAAATGCTTGTACACGGTACTTGTGGTTGAAGGCCTTAGTTG
+AATCAATGTTAGTAAGAAGCTTAGATTGAGTTGGAGAAACAAAACGAGCCATGTTGTATG
+GAGCACCTTCACTGTAAAGGTCCATTGGTGATGGTTCAGATGATAGGCTCCAACCACCTT
+CAAAGACATCAATCTTAGGACTATCTGCTTGAACATCTTGTACCCAAGAGTTGAATTCCA
+TTGGACGGCCACCAACAAATTTAGCATCTAAGCCAATCTTTTGCCATTGTTGGATGTAGT
+TAGTCCAGATCTTTTCAGCGTTTGGTTGTGTATTACGAACAGCAACGTTAATAGTTAACT
+TCTTACCATTTGGTTGACGACGGTATTTTTCACCCTTACGCTTCTTGTATCCAGCCTTGT
+CTAACAATTCATTGGCTTTCTTCAAGTTGTATGGGTAGCCCTTGATACTCTTGTCGGAGA
+AGTCTCCAAATTGTGCTGGAATTAAAGTATTAATACGGAAAGTCAAGCCATTGCTGTAGC
+GCTTGTTAACAGCATCAATGTTCATTGCATAAGCCATCGCTTTACGTAATGAAACATTGT
+TCATCTTAGCGTTCTTATCTTCAACGTTCTTACCAGTCTTCTTGTCAAACTTACCTACCT
+TAAAGCCTAAGTAGTTGTAAGATAGAGGAATCTTACCAATGAAGTTAACGCCCTTAGTAT
+CCTTAACATTGTTCCATTGAGAGTTGAGCACACCAGTAATATCAAACTTGTGACTCTTAA
+TAGCTTGAGAAACAGAGTTAGTTCCAATTACTTCCATAGTAATCTTGTCTAAGTTTGGCT
+TACCACGCCAGTAATGTTCGTTTGGTACGTAAGTAACTGATTGGCCACGAACAACCTTTT
+GAACCTTGTAAGGGCCAAAGAATAGTGGTTGCTTCCGAACTTTATCATCAGATAAAAGTT
+TCTCAAATGGAACATCTTTCAAGTAGTGGTATGGTTCTGCACTTTCAAGGAAGTAACCGT
+TACCTGATTGAAGCATACCTGGCTTCATTTCTTTGAAGTGAAGTACAACTTTTCGACCAT
+TTTCGCCATTTGGCATTTCAATACCAGAAATCTTGTCGGTCTTACCCTTATGATATTCTT
+CTAAACCAACAAGGTTAGCTAAAGAATCTGTATATCTTGAAGTCTTGGTCTTAGGGTTAC
+CAACAATTTCGTAGGCGTATTCAAGGTCCTTAGCAGTTACTTGCTTACCATCAGACCACT
+TAACACCCTTTTTAACTTCAATGGTAATTGTCTTTGCATTCTTATCTAACTTAAAGGTAG
+CTGCACCCTTATTGTTAATCTTATAGCTATCGTCAACACTAAAGAGTGATTCTAAACCTG
+GACTTTGAATTTCTGTGTCAGTAGACGTATCAGATAATTCTGGTAAGAAAATACCTGTGA
+AAGGTGAGTCACTTTCAATTGCATACTTTAATGTTCCACCCTTTTTAACTTGTTTCTTAG
+GAACAGCTTCTTTAAAACTAACTTTCTTATCGCTAGCGTTATTATTGTTGTTATTCCCAC
+AAGCAGTTAAAGTCAATGCCGCACCGGACAATACTGTAATTGCTCCTAACCACTTAACTT
+TTTTCATTTTTTCTCCCCCTTTGTGAGATGACTTAAATTTCTTGATTTTTATTATATGAT
+ATTAAAATGAAAAAAACAATACAAAATTAAAATATTTTTTGGCTAAATTTGTGTTTTATT
+AAAAATCTAGTATTAATACACTTGTTTTCTTTAAGGTGTAATCTGATAGTTATAAAAATC
+GCCAAAAGTTATAAAGAGTTATAAAAAAAGAAAGATGATACACATGAATAATAATCCTTT
+CAATCCTAGTTTTGGCAAAATACCAAGTATCTTTCTAAAACGCGATAATTTATCTCAAAG
+AATAATCGACGAATTAAATAGAGAAAATTCTCCATTTCAAACTTCACTCATTTATGGTCA
+AAGAAGGTCTGGAAAAACCACCCTTATGTCTGAAATTTCTTCTAAACTTAAAGAAAATAA
+AGACTGGATCATTATTGACTTAGTCTTTGATAATGATTTACTCATTTCTCTAACTAATCA
+ACTTCAAGAGCATTTATTAAAATTAAAACTAATTAAAAATTTAGATATAAAAATGAACTT
+TCTCGGCATTGATATTAATGCTTCCTTAGCTCAAAACATCGATGCCAATTTTCAACAAAT
+TTTGCAAACTAGTCTTGAGAAATTAACAAGAAAAGGCAAAAATGTGCTAATTAATATTGA
+TGAGGTTCATTTAACTCCTTTACTAAAGAAATTTGCCAATTGTTATCAGATCATGATTAG
+AAAAAATCTTAAGGTTTCTTTATTAATGGCTGGTCTTCCAGAAAATGTTTCTGAAATTCA
+AAATGACGATGTCTTAACTTTTCTTCTGCGATCTAATCGGATTGTCCTCAATCCATTGAA
+CTTAGAAACTATTAAACTTAGCTACAAGCATATTTTTCAAAATGCTAACTTCAATATTGA
+TGATAGAACTATTTTATATATGACCAAGCAAACACAAGGATTTGCATATGCCTTTCAACT
+TTTGGGTTATCATATCTGGAGATATGCTACAGAACAGAATAAAAAAACTATTTCTCTTTC
+TTTAGTAGACGAAATCTTAGACATTTATTTGAGTGATTTAAATCGCAATGTTTACTTTAA
+GGTTTACAATGATCTTTCTTCTAAAGAAAAAGAGTTCGTGCAAGCAATGGTAAAAGTTGG
+AAAACAAAAAGTCAAAAGCCAAGAAATCGGGAAAATAATGAATAAAGGTGCTAATTATTT
+AGCTGTTTATCGGAGAAAATTAATAGATGATCAAGTAATCAAACCTGATGGTTATGGCTA
+TGTCAGTTTCTTACTCCCGCATTTTGACAAGTTCATTGAACAAGAAATGATCTTAAATGA
+ATTCTAAAATTTCAAGCAAAAAAAGCTGGTAATACCAACGCCATTTCAAGCGAAGATATT
+GCCAGCTTTTCTTTATATTCTCTTTTCAGAAGTTTTTTTAATTTTTCTCTTAGGTGTGAA
+ATTCAAAGCTAAAACTGCCCCAATTACTAAAAATGTTCCTAGCCAATCCATCCCTGACAT
+CACCAAACCAAAGATTAAAACTGAACCAACTGTAGCTGATAAGGGCTCAAAAGCATCAAG
+CAAACTAACCGTTGACGGCTTAACATAACGTAATGCATTCGCCATAATCTGAAAAGGCAC
+TATTGTTCCCAGAATAATAATTGCTCCTACCCAGAGCCAAACTTTTGGTGTGTTTGGAAC
+AGCGGGAAAGCTAGGATGAAAAATCACCAAACCAAGTCCAGCAAAAATCATCCCCCAACC
+AGTCAAAACTAAACTCGATATTCTTTTAACAATTTTAACTGGAATCAACGTATAGCTTGC
+TTCACCTAGAGCAGATAATAAGCCGAAAAATAATGCCACTGGAGTAATTGTTAAATGATT
+TAAATTTCCATGAGTTGACAGCAAAAATACACCAATAAAAGCCATCAGTGCTGCTAAAAT
+ATCTAACCTTCTTAAAACTTGCTGATGAGTTAAAGCAAGATAAGCAAGAACAAAAAACGG
+TCCAATAAATTGTAAGATAGTCGCAATCGAAGCATTCGCCATTTCAATGACAATAAAGTA
+AAAAATCTGTACTGGTAATAAGCCAAATACCCCATAAGCAATAATGTGCAACGTATTTTT
+CTTGTCTTTTAAAACTGAAATTGGCTTTTGATGTAAAATTGTCGCAATGATTAATAAGAC
+AATCCCAGAAATAATTAGTCTTACTTGTGTCAGCCAAATAGGTGTAATTTTAGAACTGAT
+CTTAAATAAAGACTCCGCAAATAAACCTGATATTCCCCACATCACAGCTGCTAAAGCTGC
+CAAAACTGTCCACAGTCTGCTTCTAGTAACTTGCTTATCCATCCAGCTTCTTCCTCACAA
+ATAAAAATCAATCTAAATCATCATAGCATAGTTACTCTAAGCAATCATTGTAATTTCGAC
+AAAAAAATACTGTTCAATTAGGTAAGCAACCTGAACAGTATTTTTTAATTCAAATTAATC
+TAAATCTTTTCCATCAGATTCAATAACTTTCTTGTACCAATAGAATGAATCCTTGGGCAT
+TCTCTTTAAAGTACCGTTGCCTTCATCATCTCTATCCACATAGATAAAGCCATAACGCTT
+ACTCATTTGACCGGTACCTGCAGAAACTAAGTCAATACAGCCCCAAGTAGTGTAACCAAT
+TAAATCTACACCATCATCAATTGCACGCTCCATTGCCTTAATATGCATTCTCAAGTAATC
+AATCCGGTAATCATCATGAATCTTGCCATCATCGCTGATCTTATCAACTGCGCCAAGACC
+ATTTTCAACAACCATCATTGGAATGTCGTAGCGATCATACATTACTTCAAGATAATATTG
+AAGTCCATCTGGATCAGTTGCCCAGCCCCATTCGGAATACTTCAAGTATGGGTTCTTAAC
+ACCAGCAGCAAAATTACCACCAACTTTATCTTTTACTTCATGGGTAGTAATAATGTTAGA
+CATGTAGTAAGAGAAGGTATAAATGTCAACTTTTCCTTCAAGCAAGTCTTTTCGATCTTG
+CTCGGTAATATTTAAATGAACATTATGCTCATTCCATAAACGCTTAGCATAAGTTGGGTA
+TTTACCTTTTGCTTGCACATCACCGCAGGTTCCCACATATGACGGTTAGCCAAAATATCC
+TTAGGATCTGGTGTTAATGGATAGTCTACAATACCACAAATCATATTACCAACTACATAG
+TTAGGATCTAATGCATGAGCAATCTTAACTGCGCGAGCACTAGCAACAAATTGATAATGC
+AACTTTTGGTAGGCATGTTGATATACCTTATCATCAGTTACATTATTGCCAAATGCACTC
+AGCATTAAAAGCGTTGAGTTAATTTCATTAAATGTAAGCCAGTACTTAACCAGTCCTCTG
+TATTCTTCAAACAAAGTAGTTGCATACTTAACATACATATCGATCATTTTGCGATCTCCC
+CAGTCATGGTATTTTTCGCTGAGGTATAGGGGATCTTCATAGTGAGAAATAGTAACTAAA
+GGTTCAATCCCGTACTTTTTACATTCTTCAAATACACGGTGATAAAAATCTAACCCAGCT
+TGATTTGGCTTTTCTTCATCGCCTTTAGGGAAAATTCTAGTCCAGGCAATTGAAAGGCGG
+AAGATCTTAAAGCCCATTTCAGCAAACATCTTAATGTCTTCTTTATAGTGGTGATAAAAA
+TCAATTGCCACGTGGTTTGGGTAATATTCATTTGGATCAATTGCACCAACTGCGCCTTCT
+GGCAAGCCCGCCCCAGGAATACCTGGAGTTTTTTCTAACTTACCATTCAACTTATAAGTC
+AACATTCTTGGTGCATCTAAACTACCAGCAGTTGTAATATCAGTGACTGATAATCCTTTT
+CCATCTTCATCATACGCACCTTCAATTTGATTTGCGGCAGTAGCTCCGCCCCATAAAAAG
+TTTTTTGGAAATGACATTTATATTTCTCCTCTTTTTCAATACTAGTCATTTTTATTATAT
+ATGAAATCGATTACATTATCTAAGCCATTTGAGGATTTGAACTAGCTGCTTCTGTTTCAC
+TAGCTCCTTCTAAGTCTAAAATCTCTTGTCCTACTTTTACCTTGCCTTGACTTACAACAG
+TGATCTTTTCATAATCTTTTGAGTTAGTAACTACGATTGGTGTCGTTACAACATAGCCCT
+TAGCATGAATTGCATCGATATCAAACTTAACTAATTCATCACCTGCTTTAACTTCGTCGC
+CTTTTGCAACTAAGGTTTCAAAACCATGTCCTTGTAAATTAACAGTATCCATTCCGATGT
+GCATCAAGATTTCTGCACCATCGCTTGTCTTCATTCCGATAGCATGTCCTGTTGGGAAGG
+TCATTACAACTTTACCATCTGCTGGTGCATGTAGAACTCATTCGCTAGGCTCAACAGCAA
+CGCCTTCACCCATAGCACCGCTTGAGAAGACTTCATCTTTTACTTCTGATAGTGGCAATA
+ATTCACCAGCAAGTGGACTAACTAGTTCAGTTGAAACATTTAAGTCGCTAGTACTTGCTA
+AGCTTGGGGCAGCTTTCGCAATAGTATCTGCTTGGTTTGCAACTTCTTGAACAGTCTTTG
+CTTGTTTTTCATCGTAAGCTTGATCAACACTCTTCTTGCCAAGAACCATTTGTAAAATAA
+ATCCAAGAACGAATGAGACAGCCATTGCAATCATTAAACCGTAAACACTCATGTCAACAC
+CAGTCTTTGGACCAATAGCAGCAGGGATTACGAAGACTCCCATACCACCCATCATGTACA
+TCTTAGTACCGAAGAATCCAATCAAACCGCCACCAATACCAGCTGCAATACAACTTAAGA
+CAAATGGCTTTTTACGTGGAAGAGTTACACCATAAATAGCTGGTTCAGTAACACCGAAAA
+TTCCTGATAAGAATGCTGGAAGAGCAATACCTTTTAATTTTTGATCTTTAGTTTGTAATA
+AGATTGCTAAAACAACACCAATTTGTGCAAATGAAGCACCTAATGATAACCCTAAGATTG
+GGTCATAACCTAATGCAGCAATATTTGACATCATCACTGCAACAAATCCCCAGTGAACGC
+CGAAGATAACGAATACTTGCCAGAAGCCACCAAGTAAAATGCCAGCTAATACTGGACTAA
+AGTTGTAAACAGCTGAAGTAATGGCAGCAAGTGCATTACCAATCCAAGTAGCAAGTGGCC
+CGATAATTAAGAAAGTTAAAGGAACTACAATCAGTAAAGTAACAAATGGAACTAAGAAAG
+TTTTTACCACAGTTGGAATCCATTTCTTGCACCATTTTTCAACAACAGAAGCAAACCAAA
+CCGCTAAAATAATTGGAATAACTGTTGAAGTATAGTTCATTGAAATAATTGGAATACCTA
+AGAATGTAGCATGAACTTGTGAATGTAAGAACGTTCCGTTAAATAAATCAAACAAAACTT
+TTTTGCTGCTATTCATTGCTACCATTGCTGGATAACACATTGCAGCACCAATTGTAATGG
+CTGTAAAGCGGTCTACCTTAAACTTCTTAGCACTAGTAATTGCTAGAATAAGTGGCAAGA
+AGTAAAAGAAACCATCCCCAATCGCATATAAAACTTCATAAGTACCAGAGGTTTTAGCAA
+GCCAGCCAAATGAAGCACACATTGCAGTTAAGCCTTTAATCATACCTGCTGCAGCCATTG
+GCCCCAAGATCGGAGTAAAGATACCTGAAATAAGATCGATAGCTTTATCCATTAAACTCA
+TATTGCTGTCATCTAAATCATCATCAGCAACTTGGCCACCACCAGAAAAGCCACCTTCTT
+TTAAGACTGCCTCGTATACGTCAGCAACTTCATTACCAATAACTACCTGATATTGTCCAC
+CAGCTTTAACAACTGTAACAACACCATCAGTATCTTTTAAGGCATCATCATTAGCCTTTT
+TTTCATCTTTTAATTTAAAACGCAAGCGTGTTGTACAGTGAACAACGCTGATTACGTTGT
+CTTTTCCGCCAACGTCCTTAATAATCGTTTTTGCTAGAGCATCATAGTTCTTAGCCATAG
+CTTTTTTCCTCCCAATAATAAAACCCAAGCTACTCAAAAACTAGAGAACGTAAATGTTCA
+ATGTCTTTCAGTAACTTGGGTTCTTGCCTAATCGAATTAGTAACATACCTAAATATGAAA
+ATATTTAATTTTCTTGGCGGTTTGTCACGCGCCAAATATGTAAATAAGTTGCGATTCTCT
+CTGCCGTATCATAGGCATGATTGTACTTAATCTTCATAAAAGCTAATAGCGAATCATCAA
+GTTCGCCACTTTTTTGATGCTTATTTCTTAAAAGTCTTACCAATAATACTCTTAAGTGAG
+TAATGAAGCGACTATAATTAAACGACTCTGTATCTAAAGTCATTTGGTATTGATACTGAA
+TAATATCAATAATCCCGCTAATCAACTCAGTGATCTCAACTGTTTCTTGAACCTGATCAT
+TATCAGAAGCTGCATTAACGAAGTGATAAGTCATAAAAATACTTTCACTCGGTGGTAAGT
+TGACTTTCATTTCTTTATTAATTAAAGCAATGACTTTTTCGCTAATCTTATACTCCTTAG
+GAAAAAGATTCTTAACTTCCCAGCGTGTATTAGCAGCACTCATATCAATATGATCTTCAA
+TTCTTGAAAGAGCAAAATCAATATGGTCAGCTAAAGCTAAGTATTGAAAATCATTGAACT
+TCACTTTTAGAAGTGGCTCCACCATCTGGATCACCTTATTGGTTAAATCGATGGTTGAAG
+CATTGATTTCTTTAACTTGATTGACTTCATCTTGATGAGAAGTAGCGGTAAACCGCCTTT
+CAATTTTATTCTCATCAATCTTATCGCCTTTCTTTAAGCCAAAGCCCACGCCTTTGCCCA
+GGACTACTTGTTCTTGGCCTTGATCGTCCTGAACCAAGGCTGCACTATTGTTAAATGTTT
+TAAGAAATATCATCCGACGAATCACCTTTATATAGAAAAAAGCTACCACAAACTACAATA
+TACACTTTAAGTATATCATCATTATTTGTAGTAGCTCAGACCTGATCGCATCAGTAATCC
+GCTTATTTACAGTAATTATAATAGCGCTTTCACATATTTGTGTCAACAAGCATTTGCAGA
+AAAATGCTTATTTTCATGTCAGAAAAAAAGGCTAGACCTTAATGTCTAGCCTCTTTTAGG
+GATTTCAAACTAACTTTTATTATTTTTGACGCTTTTTTCTATCTACGCCTAATCCGAATA
+AACTACCTACTGCGGCAATTGCTAAGCCTAAGATACCAGCTGTATTTTCTGACTTAGCAC
+CAGTTTGTGGCAATGTATTCTTTTCAGCATGGTGATTTTCATTTACAGTAGCTGCTTTTG
+CAGTATTGGTTTCAGAATTAGTTTCTGTAGTCTTACCACCATTGTTGTCACTTGTTCCAG
+TAGCGTCTACATAGACCTTAACTGTTACATCTACGCTAGAGCCATCTGGATAAGTTACCG
+TAACAACGCCTGTATGTTCACCAATTGTAGAAACATTTGGCACTTCTTTCCAAGTGTACT
+TAGTACCTTCTGGCATATCGTTCCTGTTCTTAATACCTTCTGATGGGTTTGGAACAACAC
+CTGGAGTAGTGTGAATTGGTTGTGGCTCTGGAGTTACATGGTTCGTACCGATAATTACTG
+TTACGTTAACCTTATCTTTTGAACCATCTGGGTAAGTCACAATCACAGTGCCTGTAGTCT
+TGCCTGGCTTAGTTACATCTGGAGTCTTCTCCCAAGTGTACTTAGTGCCGCTTGGCATAT
+CATCCTTGTTCTTAATGCCCTTTTCTGCTGGTGGTACTACACCTGGGGTAGTGTGAACAT
+CTTGACCTTCTGGGGTGTACGC
+>NODE_2_length_40000_cov_63.1617_ID_3
+CCAGCGGCCAGGTCGATCGACAGCACGCACTGCCCGGTGTAGGGCAACAGGCGCTCGCGG
+TCGTCCAGGCTGCCCGCGCAGGGCTTGACCACCATGACATCGTTGGCACCGGTTTCCAGC
+AGATGGTCGATCACGCCGAGCAACTGCCCGCCCTGGTCGATCACCTTCAGGCCTTCCAGC
+TGGTGCCAGTAGTACTCACCTTCCTCGAGAGAGGGCAACTCGCTACGCGGGATGCAGATC
+TCGTAACCGGTGAAGGTGCGGGCCTCTTCGCGATCGTCGAGCCCCTTGAGCTTGGCGGCC
+AGGACCTTGCCATGCAGGCGCCCCCTGACCAGCTCGGCCTGCCGAATCTCGCCGTCGCGC
+CGGAGCGTCCAGCGGCGATAGTCCAGCAGGTTGTCCAACGGGTCGGTAAAGGAATACACC
+TTCACCTCACCGCGGATGCCGTACACCGAAACGATCTTGCCGATCACGACCAGGTCGTCG
+GCGGGTGTCGGCATTTCACTCATGACGGCTTAGGCGTTTGCCTTGGCAGCGTCCTTGAGC
+AGCTGAGCAACGCGCTCAGACGGCTGTGCACCCTGGCCGAGCCAGTAGGTAGCACGCTCC
+TGGTCGACGGACAGACGCACTTCGCCACCAGTCGCAACCGGGTTGAAGAAACCGATGCGC
+TCGACGAAGCGACCATCGCGCGCATTGCGGCTGTTGGTCACGGTCAGGTGGTAGAAGGGG
+CGCTTTTTGGAGCCGCCACGAGCAAGACGGATGGTTACCATGTGAACTTCGTTCCTGTAG
+TCGGTGCTTGCAAAATGAATGCACGCTGGGCCCACGGCCCGAAAGGCCGCATATTCTAAG
+GATTATCGGGGAATTTGCAAATCTCTTTTTCGGCCACCCATCGGCCGGCGCGGAGAGCGC
+GGGAAGCACACGGTCCGCCCGCCGGCCGACGGCGCGAAACCGCCGGCGTGGCCAGCGGCC
+GCGCGTCCGATCAAAGCTTGGGCATGCCCCCCGGGAACATACTGCCCATGCCTCGCATCA
+TCTTGGCCATGCCGCCCTTGGCGGTGACCTTCTTCATCATCTTCTGCATCTGCTTGTGCT
+GCTTGATCAGCCGGCCGACGTCCTGCACCTGGGTACCGGAGCCAAGGGCGATGCGGCGCT
+TGCGCGAGCCGCTGATCATTTCCGGATCGCGCCGTTCGCCGGGCGTCATCGAGTTGATGA
+TCGCCTCCATCTGCTTGAACTGTTTCTCCGCAGCACCCTGGGCATTGCCCATCTGCGCCA
+GGTTGACCCCGCCGAGCATCGGCAGCTTGTCCATGAGCCCGCCGAGGCCGCCCATGTTCT
+TCATCTGTTGCAACTGGTCGCGGAAGTCTTCCAGGTCGAAGCCCTTGCCCTTCTTGATCT
+TCTTCGCCAGCTTCTCGGCCTTGTCGCGGTCGAGGTTCTGCTCGGCCTGTTCGATCAGGC
+TGAGCACGTCGCCCATGCCGAGGATGCGCGAGGCCACGCGGTCGGGATGGAACGGATCGA
+GCGCTTCGCTCTTTTCGCCCATGCCGAGGAACTTGATCGGCTTGCCGGTGATCGCCCGCA
+CCGAGAGCGCGGCACCACCACGCGCGTCGCCGTCGACCTTGGTCAGGACCACGCCGGTCA
+GCGGCAAGGCGTCATTGAAGGCCTTGGCGGTGTTGGCGGCGTCCTGGCCGGTCATGGCAT
+CGACCACGAACAGGGTTTCCGCCGGCTTGATCGCCGCGTGCACCTGCTTGATCTCGTCCA
+TCATGTCGGCATCGATGTGCAGGCGGCCTGCGGTATCGACGATCACCACGTCGATGAACT
+TCAGTCTCGCCTCGCGGATCGCCGCCTCGGCGATGGCCACCGGCTTCTGGCTGACGTCGG
+AAGGGAAGAAGGTTACGCCAACCTCGCCCGCCAGGGTTTCCAACTGCTTGATCGCGGCGG
+GTCGGTAGACGTCGGCGGAAACCACCATCACCGACTTCTTCTTGCGTTCCTTAAGGAAGC
+GCGCCAGCTTGCCCGCGGTGGTGGTCTTGCCCGCGCCCTGCAGGCCGGCCATCAGGATCA
+CCGCCGGCGGCGCGACGCTCAGCGCCAGGTCCTCGTTGGCCGCCCCCATCAGCTCCTCGA
+GCTCGGCGCGGACGATCTTCACGAACGCCTGTCCCGGGGTCAGGCTCTTCGAGACCTCGG
+TACCGACGGCGCGCTCCTTGACCTTGTTGACGAAGTCCTTGACCACCGGCAGGGCCACGT
+CGGCCTCGAGCAGGGCCATGCGCACTTCGCGCAGAGTGTCCTTGATGTTGTCCTCGGTCA
+GCTTGGCCTTGCCGGTGACATGGCGAAGCGTCTGCGAGAGGCGGTCTGTAAGGTTTTCGA
+ACATGCGCGATCCTTCCACGGGGGTTGCGGCAAGCGGCGGATTATAACCAAGAGCGCGTC
+GCGGGACACGCGATGAAAGACGGAGTGTGTGTCCGGCGACGACCGGAGGCCAGCCTCAAG
+TCCTTGATTTGCCGATGCGTTCCGTCTTTGCCGAAGCGACCGCCGGACCATGAGGTCGCG
+GCGCCCGCGGCAGGCGGTCCGCCAACCCGGCCACAGGTACGAGAGAACTGTTCGCAACGG
+CTTTCTCGCGACGCTCGATCTATGCCAAACTCCCATCCTTTCGGGCCCGCGATTACAAGG
+ACTTATGCATCCCCTGCTGCCCAGCCTCATCGCTGCTGTTCTCTATCTCGGCACCGCCGC
+CTACCAGGGTGCCTGTGTGTCCAAGCGCACCGCGCCGGGCAAACCCCTGCTGCTCCTGTT
+CGGACTCCTGGCACTGGTCGCCCACGCCTTCAGCCTCTACCAGCAATTGCTGACCCCGGC
+CGGCCTGGTGCTGGACTTCTTCAACGCCGCCAGCCTGATCGCCGCCGCGGTAATTCTCCT
+GACCCTGCTGGCGACCTTGCGGATACCGGTGGAGAACCTGCTCCTCCTTCTATTCCCGCT
+GGGTGCCCTCACCACCCTGCTGGCGGTACTCATCCCCCACGGCACCGTCGAGCCGATCAA
+CGAACAGCCAGGCATTCTGGCCCACATCCTGCTCTCGATCCTGGCCTACGGCCTGCTCAC
+CATCGCGGTGTTCCAGGCGCTCTTGCTGCTGCTCCAGGACTACCGCCTCAAGCACAAGCA
+TCCGTCCGGGCTGATCCGCAACTTCCCGCCCCTGCAAACCATGGAAAGCCTGCTGTTCGG
+CTTCCTCTGGGGCGGCTGGTCGCTGCTTTCGCTGTCGCTGCTGTCCGGATGGCTGTTCGT
+CGACAACCTGTTCGCCCAGCACCTGGCGCACAAGACCATCCTGTCCTGCTTCGCCTGGGT
+GGTCTTCGCCGTGCTCCTCTGGGGTCGCCACCAGCTCGGCTGGCGGGGCCACAAGGCGAT
+CCGCTGGACCCTGGCCGGTTTCTGCCTGTTGATGTTGGCGTACTTCGGCAGCAAGCTGGT
+GCGGGAATTCATCCTGCACATCTGATGGGCCTCCTTCATGGATGAGCTGCACCCCGGGTA
+CCTGGTCGGCCTGCTGGTTCTCCTGGTCGCCTGCTCGGCGTTCTTCTCCTGCGTCGAGAC
+CGCCCTGCTCAACCTCGACCGTTACCGCCTGCGCCTGCAGGCCAAGCAAGGCCTGCGCGG
+GGCCCGGCGCAGCAGTTGGCTGCTGCTGCACGACGACCGCCTGCGCGGCACCCTGTTGTT
+CGGCCGCACCCTGGTCAACGTCAGCGCCGCCGCCCTGGCCAGTTGGGCCGCGCTGCGCCA
+CTGGGGCGTCATCGGCCTGGCCGTCGCCATCCCCGGCATGACCCTGCTCCTGCTGCTGTT
+CGGCGCCCTGCTGCCGCGCCGCTACGGCGCCCTTCGCTCGGAACGCGTCGCCCTGCCGCT
+CAGCCTGCCGCTCCTGATCCTGCAGCGCCTGTGCTGGCCCCTGCTGTGGCTGCTGACCCT
+GCTGAGCAACGCGCTGCTGCGCCTGCTCGGCGTCGCCGCGGCGGAACAGGACGACAGCGG
+ACGCAGCCGCGACGAAGAGGCCCTGCATCCGGCCGACAATCCCCAGGCCAGCGAGGTCAA
+CCGGCATGACATGCTGCTCGGCCTGCTGGACCTGGAGAAGGTCACGGTCAACGACCTGAT
+GATCCCGCGCAACGAAATCGAAGGCATCGACCTCGACGACGAACTCGAGGTCATCGTCGA
+GCAGTTGCGCACCACCAGCCACACCCGCCTGCCGGTCTACCGCGACGACGTCAACCAGAT
+CGAAGGGGTCGTGCACATGCGCCAGATCGCGCGCCTGCTGACCCAGGGCCGCCTGACCAA
+GGAGAATCTCCGCCAGGCCTGCATGGAGCCGTATTTCGTGCCGGAAAGCACGCCGCTGTC
+GACCCAGTTGGTGAACTTCCAGAAGGAGAAGCGCCGTATCGGCGTGGTGGTCGACGAATA
+TGGCGAGGTGATCGGCATCGTCACGCTGGAGGACATCCTCGAAGAGATCGTCGGCGACTT
+CAACGACCTCGACAGCCTCGACAACCCGGATATCCAGGCCCAGGAGGACGGCAGCTTCGT
+CATCGACGGCAGCGCCAACCTGCGCGAGCTGAACAAGTCGCTTGGCTGGCAATTGCCCTG
+CGACGGCCCGAAGACCCTCAACGGCCTGGTCACCGAAGCCCTGGAGCAGATCCCCGATTG
+CGCGGTGTGCCTGCGCATCGGCCCCTACTGCCTGGAAATCCAGCAGTCGGCGGAAAACCG
+TGTGAAAAGCGTGCGCGCCTGGCATCCCCGCGCGCTGACCCCGCTGGTCGAAAGCGACGC
+CAGCGTCTGATCCGGGATTGCCGAACCGGCCCCGCGGCGCTCTATAATCGACCCCAGCTT
+ATCCAGCCCTGCCGCCGGTTCCGCCGCTACCCGCAGCCCGAGCCCCGGCCAGTCACCCGC
+CAGTCCCGCCTGCCCGCCCGGCCCCGATGCCGACGGTACCAGCCGGCGCACGGCGCGCAG
+CCCCATCCTCCCTGCGCGACCGATCTCGTCCGCCCCACCCGGGCGCCGCGCCGCCGCATC
+GGCGCACTGGCCATAACCATCCGGCCGCACGGAAGCACTCCGTCGTGCCCCGACTGCCAG
+GGACCTTCCCACCATGACCGCCGCCACCCTCGCCGCCGACGCCGCTCCGGAACCGGCCAA
+CTCGACCACCCGGGTCGCAGTCGCCAGCTTCATCGGCACCGCCATCGAGTTCTACGATTT
+CTACGTCTATGCCACTGCCGCCGCCCTGGTGATCGGTCCGGTATTCTTCCCGCAGACATC
+CGGCACCGCGCAGATGCTCAGCGCCTTCCTCACCTTCGGCATCGCCTTCCTCGCCCGTCC
+GCTGGGCTCGGCGCTGTTCGGCCACTTCGGCGACCGCATCGGGCGCAAGTCGACCCTGGT
+CGCCTCGCTGCTGCTGATGGGGGTGTCCACCACCCTGATCGGCGTCCTCCCCGGCTACGA
+CAGCATCGGCTACTGGGCGCCGTTGCTGCTCTGCGTGCTGCGCTTCGGCCAGGGCCTCGG
+CCTCGGCGGCGAGTGGGGCGGCGCCGCGCTGCTGGCCACGGAGAACGCGCCGGCCGGCAA
+GCGCGCCTGGTTCGGCATGTTTCCCCAGCTTGGCCCGTCGATCGGCTTCCTCGCCGCCAA
+CGGCCTGTTCCTGGCCCTGGCGATGCTGCTCAGCGAGGAGCAGTTCCGTGAGTGGGGCTG
+GCGGATCCCGTTCCTGCTCAGCGCGGCGCTGGTTGTGGTCGGCCTCTACGTACGCCTGAA
+GCTGGCGGAAACCCCGGTGTTCGCCAAGGCCATGGCCAAGCACGAGAGGGTCCGCCTGCC
+GATCGCCGAGCTGTTCGCCCAGCACTGGCGGCCGACCCTGCTCGGCGCCCTGGCGATGGT
+GGTGTGTTATGCGCTGTTCTATATCTCCACGGTGTTCTCGCTGAGCTACGGGGTGGCCAG
+CCTCGGCTTCAGCCGCGAGGAGTTCCTTGGTCTGCTGTGCCTCGCGGTGCTCTTCATGGC
+CGCCGCCACGCCGCTGTCGGCCTGGCTCAGCGACCGCTTCGGACGCAAGCCGGTACTGCT
+GCTCGGCAGCCTGGCGGCGATCGCCTCCGGCTTCGCCATGGAGCCGCTGCTCAGCCAGGG
+CTCGACGTTCAGCGTCGCCCTGTTCCTCTGCATCGAGCTGTTCCTGATGGGGGTCACCTT
+CGCCCCGATGGGCGCGCTGCTGCCGGAAATATTCCCCACCCACGTGCGCTACACCGGCGC
+GTCGGCGGCCTACAACCTGGGCGGCATTCTCGGCGCCTCGGTGGCGCCCTATATCGCCCA
+GAAGCTGGTCGGCATCGGCGGCCTGGGCTGGGTCGGCGGCTACGTCTCCGCAGCGGCGCT
+GCTCAGCCTGCTGGCGGTGCTGTGCCTGAAGGAAACCCGCGACAACGACCTCGGCGCAGT
+GTCCTGAGTCTCGCTCAGGCTACCGCGACGCCGCCCTTCTCCCTCGCCGCCAACCAGTCG
+GCGAGGGCCCCGGCCCAGACCTGGTAGCCCAGCTGCGACGGATGAAAGCCGTCGATGGCC
+AGGTAGCCCGGAAGCAGGTCCAGCGAGATCGGGCAGTAGCCGGCGCCGGTCGCGCCAGCG
+AGATCGCACAGCGCCTCGTCGAGCAGCCGCCCGCGCCACCCCAGCAGGGCCCGCAGCAAC
+CCGGGCAAGGCGGAAAAATGCTGCAGCGGCGGCACCGCGGTGCAGGTCACCTGCGCGCCG
+GCCGCCTGGAAGCCGTCGATCAGGGCCGCGCAGTCGGCGCGCCAGCGTTCGAGGGAGCGC
+AGGCTGGTGGTGTCATTGACGCCGAAGACCAGGATCACCTGGTCGAAGAAACGTCCCGCC
+ACCTGCGGTAGCAAGCGTTCGCGCGCCTCGCCGCTGGTGATGCCGTTCTCGCCCAGCGCC
+TGCCAGGCCACCGGGCGCCGCAGACGCTCGCCCAGCGCCGCGGCCAGGCGGCCGGCCAGG
+GCGTAGTCCAGGCAACTGGCGCCGACCCCGGCCACTGTCGACTCACCGAACAACAGCAAG
+CGCAGCGGCTCTTCGGCACCGGACCCACCGACCAGCCCTTCGCGAGGTCCCGCCGCGGGC
+GCCAGGCGCAAGGCTCGGCGGCGGGTGCGGATAGCCAGCGGCACCGCCAGCGGCAGCAAC
+GGCAGAGCCGCCGCCCACCAGGCCAGCGTTGCCAGCCGGCGCATCTCAGAGTTCGACGCG
+AACCGCCTGGGCGGCCCGGGTCGCCTTGGCGCGGGCGGCGTCGATAGACTCGTCGCGCGC
+CAGGGCCACGCCCATCCGCCGCTGGCCATCCACTTCCGGCTTGCCGAACAGGCGTAGCGC
+CGTATCCGCCTCGCTCAGCGCGGCACCGAGGTTGGCGAAAGCGACCTGCCGGGACTTGCC
+TTCCACCAGGATCACCGCCGAGGCCGACGGGCCGAGCTGGCGGATCACCGGGATCGGCAG
+GCCGAGGATCGCCCGCGCGTGCAGCGCGAACTCGGAAAGATCCTGGGAAATCAGGGTCAC
+CAGGCCGGTATCGTGCGGGCGCGGCGACACCTCGCTGAACCACACCTGGTCGCCCTTGAC
+GAACAGTTCGACGCCGAACAGCCCGCGTCCGCCGAGGGCCTCGGTCACTGCCCGGGCGAC
+CCGCTCGGACTCGGCCAGGGCCTGCGCGCTCATCGCCTGCGGCTGCCAGGACTCGTGGTA
+GTCGCCCTTGACCTGGCGGTGACCGATCGGCGCGCAGAAAGTGGTGCCGTCGACGTGGCG
+CACGGTGAGCAGGGTGATTTCGTAGTCGAAATCGATGAAGCCCTCGACGATCACCCGGCC
+CTTGCCGGCGCGCCCGCCTTCCTGGGCATAGTCCCAGGCCGCCTGCAGGTCGTCGGGGCC
+TTTCAGGACGCTCTGGCCCTTGCCCGACGAACTCATGATCGGCTTCACCACGCAGGGGTA
+GCCGACGCGCTCGACGCCACGGCGGTAGTCCTCGAAGGTATCGGCGAAGTGATAGGGCGA
+GGTCGGCAAGCCGAGCTCCTCGGCAGCCAGCCGGCGGATACCCTCGCGGTTCATGGTCAG
+TTGCGCGGCGCGGGCGGTGGGCACCACGGTGTAGCCTTCGGCCTCCAGCTCGACCAGGGT
+CGCGGTGGCGATGGCCTCGATCTCCGGCACGATGTAGTGCGGCTTCTCCTGCTCGATCAC
+CGCGCGCAGGGCGGCGCCGTCGAGCATGCTGATCACGTGGCTGCGATGTGCCACCTGCAT
+GGCCGGCGCGTTGCCATAGCGATCGACGGCGATCACTTCGCAACCCAGGCGTTGCAGCTC
+GATGGCGACTTCCTTGCCCAGCTCGCCGGAGCCACAGAGAAGGACGCGGGTCGCGCTCGG
+CGACAGGGGGGTACCGATACGGGTCATGGAAGAACCTCGGAAATGAAAGAAAACGGAATC
+AGCTTCAGGCGGAACCGCTGACCAGCCCTTGCGCCTTGGCGCGCTCGAAACAGCGACCGA
+GCACCTCGCGGCGCTCGTCGTTGCTCATCAGGCCCCAGCGGGTGATCTCGGCCGCCGTGC
+GCTGGCAGCCGATACAGATGTCCTGCTCGTCCAGCGCGCAGACATGCACGCAGGGCGAAG
+CCACCGGTCGCTCGTTCACGCCGGGTCCTCGACGAGGTCGCGGGCGTAACGGCGGGCATT
+GTGCACATAGTGGGCGGCGCTGGCCTCGAGCATTTTCTTCTGCGGCTCGCTCAGCTCGCG
+CACTACCTTGCCCGGCGAGCCCATCACCAGCGAGCCGTCGGGAATCTCCTTGCCCTCGGG
+AATCAGCGCGTTGGCGCCGATGATGCAGTACTTGCCGATCTTCGCCCCATTGAGGATCAC
+CGCGTTGATCCCCACCAGGCTGTAGTCGCCCACGCTGCAACCATGCAGCATGGCGTTGTG
+GCCGACGGTGACGCCCTTGCCGAGGGTCAGCGGATAGCCCATGTCGGTGTGCATCACCGA
+GCCGTCCTGGACGTTGCTGTGCTCGCCGATATGGATCAGCTCGTTGTCGCCGCGCAGCAC
+CGCGCCAAACCAGACGCTGGCGCCGGCATCCAGGCGAACCTTGCCGATCACCGCTGCGCT
+GGGCGCGATCCAGCTGTCGGGATGGGTTTCGACGCGGGCATCGCCCAGGCGGTATTTCAT
+CGCGATCTCCTCATGGCCGGGGTCTGCGCCCCGTCGGTCAACTCAGTTTGATGAACGAAG
+CCGGCGGCGTGTGCAGGTCGATGGGGTCGTCGTACAGCAGGTTGACCAGCTCCACCACCA
+TGATGGCCGTCAGGCCCCAGATCTTGAACTCGCCGAAGCGATAGCTGGGCACGTACCAGC
+TGCGGCCGAAGTAGTCGATACGGTGGGTGACCTCGCGCGGGTCGTCGCGAAAGAAACTCA
+GCGGCACGTTGAACACCGCGGCGATCTCGCCGTCGTTGGGCTGGTACTCGACGAAGTCGG
+GAATGAAGGCGACATAGGGAGTGACCTCGATGCCATGCCGCGAGACCAGGGTGCTCAGCG
+GCCCGACCACTTCCACCAGGCCCGGCGGCAAGGCGATCTCCTCCTCCGCCTCGCGCAGGG
+CGGTGCGCACCAGGTCGGCATCTTCCGGGTCGCGCCGCCCGCCGGGGAAGGCGACCTCGC
+CGCCATGGGTGGACAAACCGGCGGCGCGCAGGGTCAGCACCAGCTCCGGATCGTCGCTGC
+GGGTGATGGGCACCAGCACGGCCGCTTGGGGGAAGCGCTGGTCGGTATCCAGTTGGCGGG
+GGCGGTGCGCCTCGATGCGTTGGCGCAGCTCGTCGAGCGTGCAGTTCATACTGCCGGGGT
+TTCCGAGGTCTTGTCGTTTCCCCGAGATCATGGCACGAAAGCCCCGGCCAGCCCACCCCT
+CCCGCACGGGGCCTTGTCGCCTCCCGGCCAGCCGAGCAAGATAGGCCTTTCCCCGAAGAA
+GAACCTGGCATGAAATTCTGCAGCCTGTGCGGCGCCACGGTGGTCCAGCGCATCCCGGAC
+GGCGACAACCGCCTGCGCTACGTCTGCGACGCCTGCCACACCGTGCACTACCAGAACCCG
+CGTATCGTCGCCGGCAGCCTGCCGGTGTGGGACGGCCAGGTCCTGCTCTGCCGTCGCGCC
+ATTGCGCCGCGCCTGGGCTACTGGACGCTGCCGGCCGGCTTCATGGAGAACGGCGAGACC
+CTCGCCCAGGCGGCGGCCCGCGAGACAGAGGAAGAAGCCAACGCGCGGATCGGCGACCTG
+CAGCTCTATACCCTTTTCGACCTGCCGCACATCAGCCAGGTCTACCTGTTCTTCCGCGCC
+GAGCTGCTCGACCTGGATTTCTCCGCCGGCGATGAAAGCCTGGAGGTGCGGCTTTTCGAC
+GAAGCGGAGATTCCCTGGTCGGAGCTGGCTTTTCCGACCATCGGCCGTACCTTAGAATGC
+TACTTCAGCGACCGCCGCGAAGGCTGCTTCCCGGTGCGCAACGAAGCCATTGCACCTATG
+CTGGCTTCCTATAAGAAAGACTGAACGCCAAACACTCGAACACCGCCGCCGTTGCGGCTC
+AAGGGAACATCGGGGATTTCACTTCCATGCGCTGGTTGCTTGCTTTGCTGTGCTTGACCT
+TCGCCAGTCTGACCCAGGCCAATGCCGCGCCGAGCCTGGAAGGCAAGGTGGACAAGGTCC
+TGGTGCTCAAGTCCGAGCGAAAACTGCTGCTCCTCAACAAAGGCAACGTCCTGAAAAGCT
+ACCGTGTCTCGCTGGGCAAGCGCCCGACCGGCCCGAAGCTGGCCGAAGGCGACAACCGCA
+CCCCGGAAGGCTTCTACTGGATCGACTGGCGCAAGACCAGCAACAACTACAACCTCTCCA
+TGCACATTTCCTACCCCAACGCCCGCGACGTGGCCAAGGCCCGGGAAAAGGGCCTGCCGG
+CCGGTGGCATGATCATGATCCACGGCACCCCGCTGGATGACGAATACCCGGAGTGGTACT
+TCTCCACCCTGGACTGGACCAATGGCTGTATCGCCATGAACAACACCGACATGCGCGAAG
+TCTGGAGCGTGGTGAAAGACGGCACGCTGATCGAGATCCGCCCCTGACAGAACCAGGCTG
+ATACCACTCGTCAGCCGTCAGCCACGCCAGGAACGCCGCCGCGAGATTTTCCGGCGGCGT
+TTTCTTTTATCCGTCAAACCCTTGCATCCCTTACTCAGGCCGAGTCAATCGACGGGACGG
+CTGGCTGACGCGTGCGCGACGCACAACTGGCATTGACGTGGTATTCAAGTGGTATTAGTT
+TTCCCAGCATTACCGGGCGACAACAACACAATCCGCATCGGAACCTCTCATGAAGACAGC
+CCACGACCTGCTCCTGGCCCTGCGTCCCGACGAGGCGCAACCCACCCCCCTCTATCTGCA
+GCTGGCGCGCAATCTCGAGAGCGCGATCCATGCCGGCCAGTGGAAAGCGGAGGAAGCGCT
+GCCCTCCGAACGCAACCTCAGCGAAACCCTGAACATTTCCCGCGTCACCGCGCGCAAGGC
+CCTCGAAGTACTCTTCGAGCAGGGCCTGATCCGCCGCAACCAGGGCTCCGGCACCTTCAT
+TACGCCGCGTCTCGAACAACCGTTGTCGCGTCTCTCCAGCTTCAGCGAGATGCTCCGCCT
+GAAAGGCTTCACCCCCGGCTCCACCTGGCTGGAGCGCGGCATCGCCCTGCCCACCCACGA
+CGAACTGATCCGCCTCGGCCTCTCGCCGACCGAGAAGGTCACGCGCATGAAGCGCCTGCG
+CAAGGCCGACGGCACAGTGATGGCGATCGAGAACAGCACCCTGCCGGCGCGCCTGCTGCC
+GGACCCGACAGCGGTCGGCGATTCCCTCTACGAATACCTGGACGGCATCGGTCGCCCAGT
+GGTCCGCGCCCTCCAGCACGTGCGCGCGATCAACGCGTCCGCGTCCGATGCCGCGCTGGT
+CGGCATCGCGCCGGGCACCGCGATGCTGCTGATGACCCGGATCGGCTACCTCGAGGACAA
+CACCCCGATCGAGCTGACCGACACCTACTGCCGCAACGACTACTACGACTTCGTCGCCGA
+ACTGCGACGCTGACCGACACGGAGCCGCCATGCTCGAAGGCAACATTCTCACCCCGCAAG
+GCTGGGTCCTCGGCCGCCTACACATCCAGGACGGGCGTATCCAGCGGATCGAAGGCGAGC
+CCTGCGACCCGGCCGGCAACGCCGATCCGTACCTGCTGCCAGGCTTCATCGACCTGCATG
+TGCACGGCGGCGGCGGCCGCGACATCATGGAAGGCGGCGACGCCTTCGCCACCATCGCCC
+GCACCCACCGGCGCTTCGGCACGACCTCGCTGCTGGCCACCACCATGACCGCACCGCGCG
+AGGAGATCGCCGACATCCTCAGCCAGCTCGGCGCTTACTGCCGCCGCTCGCTGGAGGGCG
+GTTCACGGATACTCGGCGTGCACCTGGAAGGCCCCTACATCAACTCCGGCAAGCTCGGCG
+CGCAGCCCAACTTCGCCCATGCCGCGGTGCTCGAGGAAGTCGAGGACTACCTGCGCCGCG
+CGCCGATCCGGGTGATCACCATCGCCCCCGAGATCGCCGGACACCGGCCGCTGATCCGCG
+CCCTCGCCGAGCGCGGCGTACGCCTGCAGATCGGCCATACCCTGGGCAGCTACGAGGACG
+GCGTGGCCGCACTGGAAGCCGGCGCCAGCAGCTTCACCCACCTCTACAACGCGATGACCG
+GCCTGCACCACCGCGAACCGGGTATCGTCGGCGCGGCCCTGGCCCACGCACGCTACGCCG
+AGCTGATCCCCGACCTGCTGCATGTCCATCCCGGCGCCATCAGGGTGGCCCTGCGTTCGA
+TCCCGTGCCTGTACTGCGTGACCGACTCCACCGCCGCCGCCGGCATGCCCGACGGCCAGT
+ACAAGCTCGGCAGCCACACGGTGACCAAGTGCCTGGGCGGCGTGCGCCTGCCCGACGGCA
+CCCTGGCCGGCAGCACCCTGACCATGGACCAGGCGCTGCGCAACCTGGTGAAGATCGGCC
+TGCCCCTGGCCGAAGCCTCGCAACGCCTTTCGCAATTCCCCGCCGATTACCTCGGCCTCG
+CCGAGCGCGGCCGCCTGGCGCCCGCAGCCTGGGCCGATGTGGTGCGCCTGGATCGCTCCC
+TGGAACTCGACGCCGTGATGGTGGAAGGAGAACTCGAATGACTTCGCTGATGCTCGAGGA
+AGCGCTCTCCGCCGCCGCGGTGGCGAGCCGTCAACTGGCCGTGCTCGACGCTTGCCTGCC
+GGCGCTTGGCCAGCGCCTGCGGGAGGTCGATCCAAACCTGGCGCTGACCGTCGCGCGCGG
+CAGCTCCGACCATGCCGCCAGCTACTTCGCCTACCTGGCCATGCAGCACGCCGGCTTGCC
+GGTGGCCTCGCTGCCCATGTCGGTAGTGACCCTGAACCGCTCGCCGCTGCGTGTCGCCGG
+GCAGGCCGTCTTCGCTTTCTCGCAGTCAGGACAGAGCCCCGATCTCGTGGACAGCCTGCG
+CATCCTGCGCGAACGCGGCGCCCTGGGCATCGCCCTGGTGAATGCCGAAGATTCGCCGCT
+GGAAGCCGCCAGCGAATTCGTCGTGCCGCTCTGCGCCGGCACCGAGCGCAGCGTCGCAGC
+GACCAAGAGCTTCATCGCCACGCTCAGCGCCAGCGCCCGCCTGCTCGCCCACTGGCAGCG
+CGACAATGCCCTGCTGGCCGCCGGCCAGGGCCTGGCGGCCGGGCTGGAGCAGGCCGCCAG
+GCTCGACTGGTCGCCGGCCATCGAGGCCCTGCGCGACTGCCAGCGGCTGATGGTGATCGG
+TCGCGGCGCCGGCTACGCCATCGCCCAGGAGGCCGCGCTGAAATTCAAGGAAACCTCGGC
+GATCCAGGCCGAGGCCTTCAGCAGCGCCGAGGTCCGCCATGGACCGATGGCGCTGGTCGA
+GGAGCGCTATCCGCTGCTGGTGTTCGCTCCCCGCGGCCCGGAGCAGGAAGGCCTGCTGGC
+GCTCGCCGAGGATATGCGCCAACGCGGTGCGCAGGTATTGCTCGCTGCCCCGGACGACAT
+CGCCGAACGCGACCTGCCGCTGCAGCGCGCCGCGCATCCGGCGCTCGATCCGATCCTGGC
+GATCCAGAGCTTCTACGTCATGGCCGCCGGCCTGGCCGAAGCCCGCGGCATGGACCCGGA
+CCAGCCACGGCACCTGAGCAAAGTCACCCGAACCCACTGAGCCTGAGCGCGCGCCCATGA
+ACAACAAGAATCTCGCCCTCAAAGCGCCCCTGAGCGGCCCCGTGATGCCGCTCAACCGAG
+TACCCGACCCGGTGTTTTCCAGCGGCACCCTGGGCGAAGGCATCGCCATCGACCCACTCA
+ACGACTGCCTGCACGCGCCCTGCGCCGGGCTGGTCAGCCACCTGGCGCGAACCCGCCACG
+CGCTCAGCCTGCGCGCCGACAACGGTGCCGAGCTGCTGCTGCACGTCGGCCTCGATACAG
+TACAGCTGCAAGGCGAAGGCTTCGAGGCGCTGGTCGAGGAAGGTGCGCGGGTGATCGAGG
+GCCAGCCGCTGCTGCGCTTCGACCTGGACCGCGTCGCCCGCGGCAGCCGCAGTCTGATCA
+CGGTGATGATCCTGACCAACGGCGACGGCTTCCAGGTACGCCCGCTGACCACCAACCCGG
+TGGAGGTCGGCGCGCCGCTCCTGCAACTGAGTCCGGAGAAGGCCGAGCAACGTCCGGCCA
+ATCCCGCGCCTGGCGAAGGCTCCGCGCAGCGCCAGGTCCGCGGGCGGGCGCGGGTCGCCC
+ATCATGGCGGTCTGCACGCACGCCCGGCAGCGCTGCTACGGAAGACCGCGCAGGGCTTTT
+CCAGCCAGGCCGAACTGCACTTCGCCGGGCAGGTGGCCAGCGTCGACAGCCTGGTCGGCA
+TCATGGGCCTGGGGGTCGCCGAACAGGACGAGGTAGAGGTGATCTGTCGCGGCGAAGACA
+GCGAGGCGGCCCTCGACGCCCTGCTCGCGGCCCTCGCCAGCGCCACCGCGGGGGCTCCGA
+AGGAGGCCCCGCGCGCCATCGCCTCGGGCGAGCCGGCGCGACCTGCGGCTGTCGCCGGTA
+CCCTGGCCGGCGTCTGCGCTTCGCCCGGCCTGGCCAGCGGTCCCCTGGCGCGGCTCGGCG
+CCATCAGCCTGCCGGCGGATGACGGCCGGCATCGTCCCGAGGAACAGCACCTCGCCCTGG
+ACCAGGCCCTGCAACGGGTGCGCGACGACGTACAGGGGAGCCTGCAGCAGGCCAGGCTCG
+GCGGCGACGAGAACGAAGCGGCGATCTTTTCCGCGCATCTCGCGCTGCTGGAAGACCCGG
+GTCTGCTGGACGCCGCCGACATGCTGATCGACCAGGGCGTCGGCGCCGCCCACGCCTGGC
+ACCGGGCGATTCAGGCCCAGTGCGAGATTCTCCAGGCGCTGGGCAACCTGCTGCTGGCCG
+AGCGCGCCAACGACCTGCGCGACCTGGAAAAACGCGTGCTGCGGGTGCTGCTCGGCGACA
+CCGCACCGTTGCGGGTGCCTGCTGGGGCCATCGTCGCCGCCCGGGAGATCACCCCCTCCG
+ACCTCGCGCCGCTGGTGGATGCCGGCGCGGCTGGCCTGTGCATGGCCGAAGGCGGCGCCA
+CCTCCCACGTGGCCATCCTCGCCCGTAGCAAGGGCCTGCCGTGCCTGGTGGCGCTCGGCG
+CCGGGCTGCTGGAGCTGGAGGAAGGCCGGCAGGTAGTACTGGACGCCGGCCAGGGCCGGC
+TGGAACTCAGCCCCGACGCTCGACGCCTGGAGCAGGTCGCCTTGCAAGTGGCGCAGCGCG
+AGGAACAACACCGCCGCCAGCAGGCCGATGCGCAGCGCGAGGCGCTCACCCGCGACGGCC
+GGCGCATCGAGATCGGCGCCAACGTCGCCTCGCCGCGCGAGGCCGCCGAAGCCTTCGCCA
+ACGGCGCCGACGGGGTCGGCCTGCTACGCACCGAGTTTCTCTTCCTCGAGCGCCGCGCCG
+CGCCCGACGAAGAGGAGCAGCGCAACGCCTACCAGGAGGTCCTGGACGCCATGGGCCAGC
+GCAAGGTGATCATCCGCACCATCGATGTCGGCGGCGACAAGCACCTCGACTACCTGCCGC
+TGCCGGTGGAAGAAAACCCAGCACTGGGCCTGCGCGGCATCCGCCTCGGCCAGGCGCGCC
+CGGAGCTGCTCGACCAGCAGTTGCGCGCGCTGCTGAGGGTCGAACCACTGGAACGCTGCC
+GGATACTGCTGCCGATGGTCAGCGAGGTCGACGAACTGCGCGCCATCCGTCGCCGCCTCG
+GCGAGCTGGCCACGCAGTTGGGGATCGAGCGCCTGCCCGAACTCGGGGTGATGATCGAGG
+TGCCCTCCGCCGCCCTGCTCGCCGATCAACTGGCCGAACACGCCGACTTCCTCTCCATCG
+GCACCAACGACCTGTCGCAGTACGCCCTGGCCATGGACCGTTGCCACGCCGGCCTGGCCG
+ACCGCATCGACGCCCTGCACCCGGCGCTGCTGCGGCTGATCGCCCAGACCTGCGCCGGAG
+CAGCCCGCCACGGCCGCTGGGTCGGCGTCTGCGGTGCGCTGGCCTCGGACCCGCTGGCGA
+CACCGGTACTGGTCGGCCTCGGGGTCGAGGAATTGTCCGTCGGGCCGAACCTGGTCGGCG
+AGATCAAGACCCGGGTGCGCCAGCTCGACGCCGCCGAATGCCGCCGCCACGCCCAGGCGC
+TACTGGACCTGGGCAGCGCCCGGGCGGTGCGCGACGCCTGCCTGCAACACTGGCCGCTGG
+CCTGACAAGAACAATCGGAGACCACCGCCATGCCCCCGTTCCTGATCGAAAGCCTGCAAC
+GCCTGGGCCGCGCCCTGATGCTGCCGATCGCGATCCTGCCGATCGCCGGCCTGCTGCTGC
+GCCTGGGCGACGTCGACCTGCTCGACATTCCGCTGGTCCACGACGCCGGCAAGGCGATCT
+TCGCCAACCTGGCGCTGATCTTCGCCATCGGCATCGCCGTCGGTTTCGCTCGCGACAACA
+ATGGCACCGCCGGCCTCGCCGGCGCCATCGGCTACCTGGTGATGATCTCGGTGCTCAAGG
+TGATCGATCCGGGCATCGACATGGGCGTGCTCTCCGGCATCATCAGCGGCCTGGTGGCTG
+GCGCCCTGTATAACCGCTTCAAGGACGTGAAGCTGCCGGAATACCTGGCGTTCTTCGGCG
+GCCGCCGCTTCGTGCCGATCGCCACCGGGATCAGCGCGGTCTGCCTGGGCCTGCTGTTCG
+GGGTGATCTGGCCACCGCTGCAACAGGGCATCAACGGCCTCGGCCAACTCATGCTGGAAA
+GCGGCAGCTTCGGCGCCTTCGCCTTCGGCGTGCTGAACCGCCTGCTGATCGTCACCGGGT
+TGCACCACATCCTCAACAACCTGGTGTGGTTCGTCTTCGGTAGCTTCACCGACCCGGAAA
+CCGGGCGCGTCGTCACCGGCGACCTGGCGCGCTATTTCGCCGGCGACCCGAAGGGCGGCC
+AGTTCATGGCCGGGATGTTCCCGGTGATGATGTTCGGCCTGCCCGCCGCCTGCCTGGCGA
+TGTACCGCAACGCCCGTGCGGAGCGGCGCAAGCTGATCGGCGGGCTGCTCCTGTCGATGG
+CCTTGACCGCCTTCCTCACCGGCGTCACCGAGCCGGTGGAGTTCGCCTTCATGTTCCTCG
+CGCCGCTGCTCTACCTGCTGCATGCGCTGCTCACCGGCCTGTCCATGGCCCTCACCGACC
+TGCTCGACATCCGCCTCGGCTTCACCTTCTCCGGTGGCGCCATCGACCTCGCCCTGGGCT
+GGGGCCGCTCCACCCACGGCTGGATGCTCTGGCCGCTGGGCCTGCTCTATGCCGGCATCT
+ATTACCTGGTGTTCGACTTCTGCATCCGCCGCTTCAACCTGAAGACCCCGGGCCGCGAAG
+ACGACGCGAGCAGCGAATCGGGCGACAACGCCGAAGCCGAGCGCGCCCCGGCATTCATCC
+GCGCCTTGGGTGGCGCAGCCAACCTCGAAGTGGTGGACGCCTGCACCACGCGCCTGCGTC
+TGCGCCTGGTCGACCGCGACAAGGCCTCGGACGCCCAACTCAAGGCCCTCGGTGCGATGG
+CCGTGGTACGTCCGGGCAAGGCCGGCAGCCTGCAGGTGGTGGTCGGCCCACAGGCCGACA
+GCATCGCCGACGAGATCCGCCGCGCCCTGCCCTTCGATACGCAACCGGGCGAAGCCGTAC
+CGCCGCTGGGCAGTCCGCACACAGCCGAAGAGGTGGTGGCGATGCAGGCCACCGTCGACG
+CCGCCGAAGCCCAGGCCTGGCTCGGCGCCCTCGGCGGCGCCGGCAACCTGCGCGAGGTAC
+GGGACGTCGCACTGACCCGCCTGCGGGTCAGCGTGGCGGACGAACGCAAGCTGGCCACCG
+AGCAACTGCGTCGTCTCGGCGGACAGGGCGTCAGTTCCCTCGCCGGCGGCATCTGCCATA
+TCCTGGTGGGCCCCCGCGCCGCGGCCCTGAGCCAGGCCCTGCAACCGCTGCTGCGGCGCT
+GACGGCAGGAGGGCTGGACCTCGGCCAATCGGCGGATAACCGCCAAGCGGTTATTCGCCC
+CACGCCACAGCTCCCCCGTTCGGGTTCGATAATCGCGAAGCGGTTGTTCGCGCCACGCCA
+CAGCCCCGGGTCGGGCTCTCCCCGTGAGGCGGATAACGAAAAGGGCGGCCACTGGCCGCC
+CTTCTTGCTTGTCCGAGGAAAACTCAGAAGACCATGTCGGTCAGGCGCCAGACTTCGTAG
+GCCGGGGTCTCATAGGGATGCGCCGCCTTCAGCGCCTTGACGCTGGCGTGGATGAGCTCG
+TCGGCCACCACCAGCTCCACTTTCCACTCCGCCACGTGCTCGACCTGGCCGACCTGGCCC
+AGGTAGGGTTGGCTACCGTCCAGGGGCCGGAACTGGCCCTGGCCAAGGGACTGCCAGCAG
+CAACTGTCGTACGCCCCGATGCGCCCGCCACCCGCGGCGAACACCGCTTGCTTGACGACA
+TCCAGATGGCTCTCAGGCACATAGAAACACAGCTTGTACATCGTTTTCTCCGCACGAATC
+GAATGCTGCACGAGGCGGTCGGTGGTTGTGCGACTGCCGACGCCAAATAATGGCACTTTG
+CCTTGACATGATGAATATTTGACGCTGCCTTTACGACAGATAAGCGCAACATTTGTTCGC
+TCGTCACAACACCTTCGTGCGGGCGTTCACAGATTTACGTTCAGCCGCGGAAACGCCGCC
+ACCTGGCCTTCAGCCCGGAGGCGGAAGGCGCATGGCTGCCGTCGCAATACGGCAGGTCGG
+CGGAGCGCCCGCAGCGGCACAACAGCAACAGGCGCTCGCGGGTCGCGTGGAGCGTCAGGC
+CGTTGCGGCAGTCGGCGGGACAATCGGGAAGCGAAGCCGAAGCCCCGCAGGTACAGAGCC
+GCAAGGTGTCGCCGGGAGAGACCCGGCGAACCTCGGGAAGAAGGTCGGGCGACGAGTTGG
+AGTCCGCATCGCCCGCCATGCCGGATCAGTCCACCCAGACCCGGGCGTTGCGGAACATGC
+GCAGCCAGCCGCCGTCTTCCTGCCAGTCGTCCGGACGCCAGGAATTCTGCACGGCGCGGA
+ACACCCGCTCGGGGTGCGGCATCATGATGGTGACCCGGCCGTCGCGGCTGCTCAGCCCGG
+TGATGCCGCGCGGCGACCCGTTGGGGTTGGCCGGGTAGGCTTCGGTGACCTTGCCGTGGT
+TGTCGACGAAACGCAGCGACACGCAGCCGGAAAGGTCGGCCTCGAGCAACGCTTCCTCCG
+ACTCGAACTCCGCATGGCCTTCGCCATGGGCGATGGCGATCGGCAGGCGCGAACCGGCCA
+TGCCCTGCAGGAAGATCGACGACGACTCCTGCACCTGGACCATCGCCACCCGCGCCTCGA
+ACTGCTCGGAACGGTTGCGCACGAAGTGCGGCCAGAACTCGGTGCCGGGAATCAGCTCGT
+GCAGGTTGGACATCATCTGGCAGCCGTTGCAGACGCCGAGGGCGAAGCTGTCCTTGCGCG
+CGAAGAACGCCTGGAAGCCGTCGCGGGCGCGGGCGTTGAAGAGGATCGACTTGGCCCAGC
+CCTCGCCGGCGCCGAGCACGTCGCCGTAGGAGAAGCCACCGCAGGCCACCAGGCCCTTGA
+AGGCGTCCAGGTCGACCCGCCCGGCGAGGATGTCGCTCATGTGCACGTCGATCGCGGCGA
+AGCCGGCGCGGTCGAACGCCGCGGCCATCTCCACCTGGCCGTTGACGCCCTGCTCGCGGA
+GGATCGCCACTTTCGGCCGCACGCCCTTCTTGATGTAGGGCGCGGCGATGTCGTCGTTGA
+CGTCGTAGCTGAGCTTGATCGACAGCCCGGGGTTGTCTTCGTCCAGCAGCGCGTCGAACT
+CCTGCTCGGCGCAGTCGGCGTTGTCGCGCAGACGCTGGATCTGGTAGCTGGTCTCGCTCC
+AGATGCGTTGCAGGATGCGGCGCTGGGCGCTGTAGACGGTCTCGCCGTTGTAGTTCAGGT
+TGATCTCGTAGCCGTTGACCGGCTGGCCGATCACCGCCACGCAGTCGTCGAGACCGGCGG
+CGCTGAACTGCGCGAGGACTTCCGGAGTGGCACCCTCGCGAACCTGGATCACCGCGCCCA
+GTTCCTCGCTGAACAACACGGCCGCCAGCTCTTCGCGGCTATCGGCCAGGGCATCGAGGT
+TCAGCTCGACGCCGCAGTGACCGGCGAAGGCCATCTCCAGCACGCTGGTGATCAGGCCGC
+CGTCGGAACGGTCGTGGTAGGCGAGGATATGGCCGTCGGCATTGAGCCCCTGGATCACCG
+CGAAGAAGGCTTTCAGGTCCTCGGCGTCGTCGACGTCCGGCACGGCGCGGCCGAGCTTGC
+CGTGGACCTGGGCCAGGATCGAGCCGCCGAGACGGTTCTTGCCGCGGCCGAGATCGATCA
+GGATCAGGTCGGTCTCGCCCTTGTCCAGGCGCAGTTGCGGGGTCAGGCTCTGGCGCACGT
+CGGCGACCGGGGCGAAGCCGGTGACGATCAGCGAGACCGGAGAAGTGACGCTCTTGTCCT
+CGCCATTGTCCTGCCAGCGGGTCTTCATGGACATCGAGTCCTTGCCCACCGGGATGGTGA
+TGCCCAGTTCCGGGCACAGTTCCATGCCCACGGCCTTGACCGTGTCATACAGGCGCGCGT
+CCTCGCCGGGGTGGCCGGCGGCGGCCATCCAGTTGGCGGAAAGCTTGATGTCGGACAGCT
+TGCCGATACGCGCGGCAGCCAGGTTGGTGACCGTCTCGCCGATGGCCATGCGTCCGGAAG
+CCGGGGCGTCCAGCAGCGCCAGCGGGGTACGTTCGCCCATCGCCATGGCCTCGCCGGTGT
+AGACGTCGAAGCTGGTGGCGGTGACGGCGCAGTCGGCCACCGGCACCTGCCAGGGCCCGA
+CCATCTGGTCGCGGGCCACCAGCCCGGTGATGGTGCGGTCGCCGATGGTGATCAGGAAGC
+TCTTGCTGGCCACGGCGGGATGGCGCAGGACGCGCTCGACGCTTTCCTGCAGCTCCAGCC
+CGGCGGCGTCGAAATCGTCGCCCAGCTCGGCCTCGCGGGTGACCGCGCGGTGCATGCGCG
+GCGCCTTGCCGAGCAGGACTTCCAGCGGCATGTCCACCGGCTTGTTGTCGAAATGGCTGT
+CGGCGACGGTCAGCTGGCGCTGCTCGATGGCCTCGCCGACCACCGCGAACGGGCAGCGCT
+CGCGCTCGCAGATGGCCTTGAAGGTCTCGAAGTCGGCGGCGTCCACCGACAGCACGTAGC
+GCTCCTGCGACTCGTTGCACCAGATTTCCAGCGGGCTCATGCCCGGCTCGTCGTTGGGCA
+CCGCGCGCAGCTCGAAGCGACCGCCGCGGCCGCCGTCGTTGATCAGTTCCGGCAGGGCGT
+TGGACAGGCCGCCGGCACCGACGTCATGGATGAAGCTGATCGGGTTGCGCTCGCCGAGCT
+GCCAGCAGCGGTCGATCACTTCCTGGCAACGTCGCTCCATTTCCGGGTTGTCGCGCTGCA
+CCGAGGCGAAGTCGAGGTCGGCGGAGCTGGCGCCGGTGGCCATCGAAGAGGCGGCGCCGC
+CGCCCAGGCCGATCAGCATGGCCGGGCCGCCAAGGACGATGAGCTTGGCGCCGACGCTGA
+TCTCGCCCTTCTGCACGTGTTCGTCGCGAATGTTGCCCATGCCGCCGGCGAGCATGATCG
+GCTTGTGGTAGCCGCGCACTTCCTCGCCGTGAGGGGTAGCGATCTTCTGCTCGAAGGTAC
+GGAAGTAGCCGGTCAGCGCCGGACGGCCGAACTCGTTGTTGAACGCGGCGCCGCCCAGCG
+GGCCCTCGATCATGATGTCCAGCGCGGTGACGATGCGCTCGGGCTTGCCGTAGGGCACTT
+CCCAGGGCTGTTCGAAACCGGGGATCTGCAGGTTGGACACGGTGAAGCCGGTCAGGCCGG
+CCTTCGGCTTGGCGCCGCGGCCGGTGGCGCCCTCGTCGCGGATCTCGCCGCCGGAACCGG
+TGGAGGCACCGGGGAACGGCGCGATGGCGGTCGGGTGGTTGTGGGTCTCCACCTTCATCA
+GGATCTGCACCGGCTCGCGGCTGGCGGCGTATTCGCGGGTCTGCGGATCGGGGAAGAAAC
+GCCCGGCGACATGGCCGACGATGACCGCGGCGTTGTCCTTGTATGCGGACAGCACGCCTT
+CGCGGTTCATCTCGTAGGTGTTCTTGATCATGCCGAACAGGCTCTTGTCCTGGGCCTGCC
+CGTCGATGTCCCAACTGGCATTGAAGATCTTGTGCCGGCAATGCTCGGAGTTGGCCTGGG
+CGAACATCATCAGCTCGACGTCGTGCGGGTTGCGCCCCAGTTCGCCGAAGCTCTTCAGCA
+GGTAGTCGATCTCGTCCTCGGCCAGGGCCAGGCCCAACTCGACGTTGGCCTTCTCCAGCG
+CGGCGCGACCGCCGCCAAGCACGTCGACGGCGGTGAGCGGGCGGGGCTGCGCATGGCTGA
+ACAGCTCGGCGGCGCCTTCCAGGCGGTCCAGCACCAGTTGGGTCATGCGGTCATGCAGGC
+GGGCGGCGACCTGCTGGGCGTCGCTCTCGGACAGTTCGCCCTGCACATAGTAGGCAATGC
+CGCGCTCCAGCCGGTCGATCTTCGCCAGGCCGCAGTTGCGGGCGATGTCGGAGGCCTTGC
+TCGACCACGGCGAGATGGTGCCGAAGCGCGGCACCACCAGGAACAGCCGTCCGCTGGGCT
+CCTGCACCGGCACGCTCGGGCCGTATTTCAGCAGCCGCGCCAGCACCTGCTCCTCGTCGG
+CGGTGAGCGCGCCGGTGACGTCGGCGAAATGCGCGAACTCAGCGTACAGCCCGGTAACGG
+CAGGTACGTGCTGGGTCAGTTGCTCGAGCAGTTTGCCGTGGCGGAAAGCGGAAAGGGCGG
+GAGCGCCGCGCAGGATCAGCATTGTCGGAACAGCCTCTGGAGACGGGAAGGTGTGGGGGC
+CGGCCGGGCCGGCCCGCAGAGGCCGTGCATTCTACCGTAAAGCACCGTCCGGCGGCACCC
+GCGCCGATGGCTATCGCATAGCCCTCCATCGGATCCGCGGCGGCCCGCTTCGAAGCACTT
+CGAGAACGGCGCCGCAGCGCTCTGCGACGGGGCAAGCGAAACGGCGGACGAACGGTATCC
+CGGCGATAGCAGAGAAGGTCCCGGCTGTCGAGATATGGCGCCGTCTCGCCTTTGCGTATA
+CTGCGCCGATGTTTGCCCTGACCGCGTACCGCTTACGTTGCGCCGCCTGGCTGTTGGCGA
+CCGGCATCTTTCTGCTGCTTGCGGGCTGTAGCGAGGCGAAAGCCCCTACCGCCCTGGAGC
+GCGTGCAGAAGGAGGGCGTACTGCGCGTGATCACCCGCAACAGCCCGGCCACCTACTTCC
+AGGACCGCAACGGCGAAACCGGCTTCGAATACGAACTGGCCAAGCGCTTCGCCGAGCGCC
+TCGGCGTCGAGCTGAAGATCGAGACCGCCGACAACCTCGACGACCTCTATGCCCAGCTTT
+CCCGCGAGGGCGGCCCGGCGCTCGCCGCGGCCGGCCTGACCCCGGGACGCGAAGACGACG
+CCAGCGTGCGCTACTCGCACACCTACCTCGACGTCACCCCGCAGATCATCTACCGCAACG
+GCCAGCAGCGCCCGACCCGCCCGGAAGACCTGGTCGGCAAGCGCATCATGGTGCTCAAGG
+GCAGCAGCCACGCGGAGCAGCTCGCCGAGCTGAAGAAGCAGTATCCCGAACTGAAGTACG
+AAGAATCCGATGCTGTCGAAGTGGTCGACCTGTTGCGCATGGTCGACGTCGGCGACATCG
+ACCTGACCCTGGTCGACTCCAACGAACTGGCGATGAACCAGGTGTACTTCCCCAACGTCC
+GCGTCGCCTTCGACTTCGGCGAAGCCCGCGGGCTGGCCTGGGCCTTGCCGGGGGGCGACG
+ACGACAGCCTGATGAACGAGGTCAACGCGTTCCTCGACCAGGCCAAGAAGGAAGGCCTGC
+TGCAACGCCTGAAGGACCGTTACTACGGGCATGTCGACGTACTCGGCTACGTCGGCGCCT
+ACACCTTCGCCCAGCACCTGCAGCAACGCCTGCCGCGCTACGAAAGCCACTTCAAGCAGA
+GCGGCAAGCAGCTGGATACCGACTGGCGCCTGCTCGCCGCCATCGGCTACCAGGAATCGC
+TGTGGCAGCCCGGCGCCACCTCCAAGACCGGCGTGCGCGGCCTGATGATGCTGACCAACC
+GGACCGCCCAGGCGATGGGCGTGTCCAACCGGCTCGACCCGAAGCAGAGCATCCAGGGCG
+GCAGCAAGTATTTCGTGCAGATCCGCAGCGAACTGCCCGAGAGCATCAAGGAACCGGACC
+GCAGCTGGTTCGCCCTGGCCGCCTACAACATCGGCGGCGCGCACCTGGAAGACGCGCGCA
+AGATGGCCGAGAAGGAAGGCCTCAACCCGAACAAGTGGCTGGACGTGAAGAAGATGCTGC
+CGCGCCTGGCGCAGAAGCAGTGGTACGCCAAGACCCGCTACGGCTATGCGCGCGGCGGCG
+AGACCGTGCACTTCGTACAGAACGTGCGGCGCTACTACGACATCCTCACCTGGGTGACCC
+AGCCGCAGATGGAAGGCAGCCAGATCGCCGAGAGCGGGTTGCACCTGCCCGGCGTGAACA
+AGACGCGCCCGGAAGAAGACAGCGGCGACGAGAAACTCTAGCCGCCCCCTCCCCTCAGGA
+TTCTCCGTCGCTTGCCAGCCAGGCGGCGTGCTCGCGCACATCGGTCGGCCAGCCGGCGAT
+CCGCTCGGCGAAGCCCTCGCGATCCCCGGCGAACAGCGCACGCGTCGCCTCCTCGAAGCC
+CGGCAGGTCGCCGGCCATCGCATTCATGAAATGGTAGGCGCGCTCCTGCGCCTGCCGCGC
+ACGCCCGGACTGGCTGCGGCGCGCCTCCTCGACCAGCTTGCGCAGCGCCACCGAGGCGCC
+CCCGGGCTGCGCGGCGAGCCATTCCCAGTGGCGCGGCAACAAGGTCACCTCGCGCGCCAC
+CACGCCCAGCTTCGGCCGCCCGCGCCCGCGCGGCGCGGCCTCCTCCGCCGGTTGCCGCTC
+GCCTGCGACGACCAGGCGCGCCAGCTGGTCCTCGCTGGAACCACGGATATCGAGATCGAC
+GGAGCGCCCAGTGGCATTGTCGAATACCAGCAGCGGTCCGGCTGCACCGCCGGCGACCGC
+TTGCTTCAAGGCCAGCGCGACCTCCGGCAGCGCCGCCGTCAGCAGCCGGCGCGTGCCGTC
+GAAGCAGGTGAAGGATTGGATGTATGGATCATTGGCCATGACAGGCTCCCATGGATGGAA
+CGCCCGAATAATACCCGGATATAAATAGAGCGACAATATTATCCGGATAAAATAAATCCC
+ATGAAAAAGGCCGCCCTATGGCGGCCTCTTCCGGCAGCGATGACCTACCAGCCGGCCGGC
+AGCAGGTTCATGGCGCTGCAAATGGCGTAGGCGGCGCTGGCCAGGTAGATCGTCACGATC
+ACCGCCTGGATCGCCGGATGGGCGATCCAGCCGCATTTCCAGGCCGGCTCGAAGTCGCCG
+TTCCTACGCGCCGAGCGCAGCATCAGGATCGGCATGATCGAGAGAATCACCCCGCTGAAG
+GCCCCGGCGAAGTACAACGCGTTGACGAAGCCGACCAGCCCGCTGTAGGCCAGGACGAAC
+GGCGGCAGCGCGACGATCGCCAGCACCAGCAGGCGGGTCTTCGGCCGGTTCTCCGGACCG
+AGCTTGTGGAACTTGTCGAAGATGTTGGTCAGGAAGCTACCGCCCAGGCCCCAGTAGGAC
+GTCAGCATGGCGCACAGGGCGAAGGTGTTGGCGGTGAAGAAGGCCCATTCGCCGAGCGCC
+TTGCCCCAGGCCAGGGTGGCGACTTCGGACTGGTTCTCCAGGCCGGTCAGGGCGATCACC
+GAGAGCGGCACGATGCTGAGCAGGACGAAGGTGGTCAGCATCCCGGTGATCACCGCCTTC
+GGCAGGCGCTCCGGGGCGTGGCTGAAACCACGGGCCATCTCCGGGACGATGTACTGGGCG
+GAGAAGCAGAACACCGCGATGTTGAATACCGGCACCATGTAGATCCAGTCGCCGTCGAGC
+AGACGGGCGAACTCGGTATTGTCGTTGAGCAGGGTGGCCGCCACCAGGATCAGGATCATG
+CTGACCATGCCGATGCTGATGAACTTCTCGCCCTTGCCGATGGCGCTCAGCCCCAAGTAC
+AGCACGCCGGCGGCCGGAATGAAGAACAGCACGCTGCCCAGGGCCGGGCTGATGCCGAAG
+AAGGCGCTGAGGATCTTGCCGCTGCCGCTCATGTAGGCGATCAGCGCGCCGATGCTGTTG
+ACCGCCACGGACAGGAAGATCGCCCAGGCGCCGAAGGAGCCGACATAGCGCTGGGCAAGG
+CCGCTCAACTGGTTGTGGGTGCGCGTGCGCAGGGCGGTTTCCGAGACGTAGAGCATGGAA
+ATGGTGGTGAACAGGCCGGCCACCGCCAGCCAGAGCAGCAATGGCATGAAGCCGGCCTTG
+CGGCTGGCGTAGGCCATGGACAGCACGCCTGCGCCGATGTTGGTTCCGACGATCATCGCC
+ACCGCCTCGAGGAACGTCAGGCGCTTGACCTCCAGTCCCGAGGAATCGACGGCTTCCGCC
+CCGGCGTGATCCTGATACTGCTGGACCCGGGTATCACTCATGACAACAACTCCCTGCATT
+TCGAATTGGCATTGTGCGGGAGGCGGCCAGGACCGCCGTACCGATGGCCTTCTTCGAGGA
+CAATGCAGGGCCGGGAATCGCGGACGCCTCCGGACCGGCCGCGCTTTTCGGCTGCGCGGT
+CCGGCGGGGGTATCCGCAGGCGGGCTCGCTCTCACCTGAAGCCATTGCCTGCGGGCCGCT
+TGCTCAAGCGGCCGTGCAAAATATCACACAATTCGACGAAGGAAGCGCGCGGCGACTACG
+ACTTTACGCCTATGCCGATCGTCCGAAATATCCGGATAAATAATTGATGCAGATGGCTTT
+TGAAGGAGAGGAAGGGGCAAGGACGTGCTTTAACGTTTCAGCCGGAGCGTTCGAAAAGAG
+AAACATCCGTCAGTCTTCGCGAGGCTTCTTCGCCGCTTCGCGCCGCGCGCGGAAGAACGC
+CGAGAGCGCCTGGCTGCATTCTTCCGCCAGCACGCCACCCTCGACCATGACCCTATGGTT
+GAGATGCTCCTGCTCGAAGAATCGCCCACGGCTTTCCACTGCGCCCGACTTGGGCTCGAC
+CGTGCCGTACACCAGGCGCTGGATGCGTGCGTGCACCAGCAGTCCGGAACACATGCTGCA
+GGGTTCCAGGGTCACATACAGGGTGCTGCCTGGCAGCCGGTAGTTGCCCGCCTCCGCCGC
+TGCCATGCGGATCGCCAGCATTTCGGCGTGGGCACTGGGATCGTGGCTACTGATCGGCCG
+GTTGAAGCCCCGCCCGATGATCTCGCCCTCGCGCACCAGGACCGCGCCCACCGGCACTTC
+GCCGAGGGCCGCGGCCTTTTCCGCCTCTGCCAGGGCCTCGCGCATGAAATGCGGGTCCCG
+GCTGCGATCGATGATCGGACGCACGCCTTTTACCGTCGGGTAGCCCTTGCCGTTGCTGAT
+CAGCTTAGTCACCCGCACCAGGCCTCGCCGACCGCGATGGTCCCCATCAGGCCGGTCTCC
+ATATGGTCGATGACGTGGCAGTGGAACATCCACAGGCCCGGATTGTCCGCCACCAGCGCC
+ACGCGGGCAGTCTCGTTCTTGCCCAGCAGGTAGGTGTCGGTGAAGTACGGGATGATCTCC
+CGGCGATCCGAATCCAGCACCTTGAAGGCCATCCCATGCAGGTGGATCGGGTGCTGGTAC
+TGCGCCATGTTGCGCAGCTCGAAGATGTAGCTCTGGCCTTCCTTGAGCTTGGCCAGCGGC
+GGCGCGTTGTGCTTGTGCTCCTCGCCGCCTTCCCAGGCCTTGCCGTTGATCTGCCAGAAC
+GACGGATAGGGATTCTTGCCGCTGGTATCGGACATCGCCCCGACCCACTCGAAACGGAAA
+CCGATCTTCTCGGCATTGGCCAGGTCCGGTTCGCTCACCGGATTCGCCGGCAACGGCTTC
+GGCCAGTCGCCGGCAGGTGCCTCGGCGCTGGCCACGCTGCGGATCGTCGCCAGGCGTACC
+GGCCCGTCGCGCAGGGACAGCTCGGTGCCCGCTTCCGGCACCTTCAGCGCCAGCTCCAGG
+CGCATCCCGGGACCGATCCAGTACTGCCCCTCGAAGCCGCGTGGTTCCACCGGATGGCCA
+TCGATGGCATAGATCCTCGCCTCGCCGTTGGGCAGGTTGAGACGGTAGGTGACGGTGTTG
+TCGACGTTCAGCAGGCGCACCCGGACGATCTGCCCGGCCGGCAGGTCGATGGTCGGCACA
+TGCTTGCCGTTGATCGTCGAATAGCGCCCGCGGGTGCCTTCGCGCGCGGCCTGGCGCGGC
+ACGCTGAAGGGGGTGAAGGCGCCCTGCTCGTCCACGTGCCAGGTCTTCAGGCAGAGAACC
+TTCTCGTGGCGGAACCCGGTGGGTTCGCGCTCCTCGATGATCAGCGGGCCGACCAACCCG
+CGGCCGAGCTGCTCGCTGCTCATCAGGTGCGGGTGGTACCAGTAGCTGCCGGCGTCCTGG
+GTCTTGAACTGGTAGATGAAACTCTCGCCCGGCTGCACCGGCGGCTGGGAAATGTACGGC
+ACGCCGTCCATCTCGATCGGCAGGCGGATGCCGTGCCAGTGGATGGTGGTCGGTTCGTCC
+AGCCTGTTGGTGAAGCGCACCCGCAGCCACTCGCCCTGCTTCGCCCGCAACTCCACGCCG
+GGGCACTGGCCGCCATAGGCCAGCGCCGGACTGCTGAAGCCCGGGACGATCTCCAGGTCC
+AGCGGCGCGGCGATCAGTTCGTAGTCGTACTCCTGCGCCACCTGCGGACGCGCCAGCCAG
+AAGCGCGCGCCGCCGGCGCCGAGGCCGACCACCGCCAGCCCGGCGAGGCCGCCGAGCACT
+TGTCTACGGGTAAATGTCATGGAGCCTTCACCTTCGCGGTACTGCGGCTGGGAAATGATA
+GATTTTCTCATTTCCACGCCCACAAGGCGAGTTCTCGCTCGGAACAAATACACTCCCGCT
+GACCTGCAGCAAGCAAAAGAGCTCCCCAGCGCCAGCGGCGGATCGCTGGTCGCGGACTAC
+GCTCAGGCTACCTTCACGATGCGCTTGCCGAAGTTCTCGCCATTCAACAGGCCGACCAGA
+GCCGCCGGCAGGCTTTCCAGCCCGTAGAGCACATCCTCGTATACCTTGATCTGCCCGGAG
+TCGACCCATGCCTTGAGATCGGAGAGCGCCCGCTCTCTGCTCTCGAGAAAGTCGCCAAGA
+AGGAATCCGCGCAACGTCAGGCGCTTGATGATGAGTAGCCCGGGGATCCCGGCAGGACCG
+GCGGCGGGTCGGTCCAGGTCGTATTGCGAAATCGCGCCGCAACAGGCGACCCGTCCATGC
+TCCGCCATGTTCGGCAGGCAGGCATCGAGGATTGCACCGCCAGTGTTGTCGAAATACGCG
+TCGATCCCGTCCGGACAGGTCCGCCGCAAGTCATCGGCCAGCGTCCCCGTCTTGTAGTCG
+AGTGCCGCGTCGAAACCCAGTTCACGAACCAGCCAGGCGCATTTGCTGGCGCCTCCCGCA
+ATGCCGATGGTACGGCAGCCCCTGATCCTGGCGATCTGCCCGACGATAGAGCCGACGGCA
+CCGGCGGCGGCAGACACTACCAGCGTTTCGCCCTGCACCGGCCTGGCGCATTCGAGAAGG
+CCGAAATAGGCCGTCAGGCCTGCTACGCCGTAGACGCTGAGCAGATGCGTGAGGGGCTCC
+AGGCGCGGCAGCCTGATGAGCCCGGCCGCCGGCACGACCGCGAAAGTCTGCCAGCCGGTC
+TCGGCACAGACCAGGTCGCCGGGCTGGAACGACGCCGAGCACGATTCCACCACCTCGGCC
+AGTCCCAACCCCGCCATCACCTCCCCGGCCACGAGGCCGGGGCGATAGGTCGCGCCTTGC
+ATCCAGGCCCGGCTGGCGGCGTCCAGCGGTATGTACAGGACACGAAGCAACAGCTCACCG
+TCGGCCGGAACCGGACAACGCACCTCGCGCCCCTGAAAATGCCGGACAGCGAGCGCAGTC
+CGGGGAAGCTCGCTCAGAACGATCTGACGGTTGATCATCGCTTCTCTCCCGCCGCGAGAG
+CGACACTGTCGCTGGCCTCACCGCCGAAAGCGGGAGGCATGTGAAACTGTCTGTCGTGCA
+TGCTGTTCTCCGAGTCGATGGCAACCTGATGCAATCTCATTGTGAGAAAACATCTCCGGA
+CTTAGAATGCAAAAAACTCCTATCTTCTATCGCGATCGTCCAGCATCAATGGATCCTCTC
+TCCGAAGTCCTTTCCCTGGTCAACAGCCAGGACTCCTCCTTCGGCGCCCTGAAGACCGGC
+GGCGATTGGGCACTCCGCTTTCCGGCACCGGAAGGTGTGAAGTTCAACGTGGTAGTCCGT
+GGCGCTTGCCTGCTGGCCACCGACGGCATGGAAGAGCCGATCCGACTGGAAGCGGGCGAC
+TGCTTTCTGGTGTCCTGCCGCAGTCCGCTGCTGGTCGGCAGCGATCTATCCCTTCCCGCC
+GCCGACGCCACGCTGCTCTACCGAGATGCCCCTGACGGCGTCGCGCACTATGGGGAAAGC
+GAGGATTGTTTCCTGATCGGCGGTCGCTTCGCCTTTGGCGAAGAAGCCAACCTGCTGTTC
+GACGGGCTGCCTCCGGTGACCGTCGTGAAAAGCGATTCGGACCAGGCATCCGTACTGAGC
+TGGGCGCTGCACCGACTGGCCCATGAGTTTTCCTGCCCGTCACCCGGTAGCGCGCTGATC
+GCTCACCACCTGGGCCACATCATGCTGGCGCAGGTGCTGCGCCTCTATCTCGCCGGCAAG
+GGCAGCGACACGCCCAGTTGGCTGCTGGCGTTGTCCGATCCGCGCATAGGCGCGGCGATC
+CGGGCGATCCACGCCGAGCCGGCCAAAGTCTGGACGGTCGAGCGCCTGGCCGACGTAGCG
+GGTACCTCGCGCTCCACGCTGGCCCTGCGTTTCAAGCAAACCGCGGGACTGGCGCCGCTG
+GAATATGTATCGCACTGGCGTATGCAATTGGCGGCTCGCGCCCTGCGCGACAGCAAAGCG
+ACGATTTCCTCGATCGCGCAAACCCTGGGCTACGGCTCGGACAGCGCCTTCAGCAACGCC
+TTCAAACGCATCATGAAATGCTCGCCCAGAGACTATCGCAGCCGGCAGGCCAGCAGGGCA
+TAGCGCTCGGCGAACCGCCCATGCGGCAGGTTCCCCGAGCGGTCGAGCGCATGGTCAAAC
+GACCGACGGAGCTTGCCACGGTATCTTTCCCGCCCGAAGGATGATCCCGATGGCCAGGAC
+CACGCACGCGCCGAAGGCATAACGCAGGCCGAACGCTTCGGAGAGAAAGCCGATCAGCGG
+CGGGCCGATCAACGTGCCCAGGAATCCGATCGTCAGAACGGCTGCGATAGCCGAACTCGG
+CGCCATGCTCGAGGAGCGGGCGGCGGCCCCCGCCACCAGCGGAATGACGGTACAGATGCC
+GAGACCGACAAGGCAGAAGCCAATGATCGACGCCAGCAGGCTCGGATAGGCGATCGTCGT
+GACCATGCCGATCAAGGCGAGCCCCCCGCTCCACTGCAAGGTGCTGCGCGTACCGAAACG
+GTCGGCGACTCGGTTCAGCAGAAGCCGGCCGACAGTCATGGCGCCCATGAACACCATGAA
+GCCGACTCCGACCAGTTGCCGCTCGGCCGAGACCACGTCCTGGAAATAGACGACGCTCCA
+GTCATACATGATGCCTTCGCAGGCCATCGAGAAAAAAACGATCAGCCCGTAGTTGAAAAG
+CCTCCTGTCCGGCATCGTGAAGGCCCGCCCGACCCGCTCCGCGCCAGGCTGGTCGTGGAG
+AAAGCGCCAGCAGGCCAGGGCGGCCAGGAAGGCGATCACCGATATCACGCCGAAATGCGT
+GGACAAGGCAAAGTCCTGCCCGATCATCAACGCCCCGAACCCGGCGCCGACGAATCCCGC
+CAACCCCCATATACCGTGGAAAAACGGTAACTCGGTCTTTCCGATGAGCGCCTCCGACAG
+GCTTGCCTGGGTATTGTTCGACACATTGACCGCGCTATAGGAGAACCCCGATACGAACAA
+CAGAGCAGCAAGCTGGTAGACGCTAGAAGCCAAGGGAACCAACGACAGCAGAACGGCGTT
+CGCGAGAATCGCCGTTACTCCAACGTTTCTGCTGCCGAGCTTCGCGATCATCCAGCCGGA
+TACCGGCAACGAGAGCACCACCCCGGCCGACATGGCGAAAAGCGCACTGCCGAACACCCC
+GTCGGAAAGCTGGAGTCCGTCTTTTATCGTGGCCATCCGGGAGCTGAGGCTCCCGAAACA
+CAATCCGAGCATGAAGAACATGCCGGAGATGGCAATACCTTTCCCTACGCTGCTGGAGGT
+CATTCGATCGATCCCGGTGCTTGTTTGATGGACAGAAAGCGCGGTATCCGCGACGTCTTC
+CGTGTGCTCGACTAGGACGCGAATGCGTCGATCCCGGTGAGCGTCGCCGAAAGCCTCCAG
+AGACGGCGGGCCTGCTCCGGATCGATCGCATGCTCGCGTACGCCGGCCAGGGTGCGCGAG
+TCGTCCGGCGCGATGCCTGCGATGTCGCAATCCTCGCAGTAGAGCCCGCCCATCCCCGCC
+AGCAGCGGAGAGGTCGCAGCCCACAGCTGGGTGGCAGCCCCCTGCTGCGGGGTCTTGAGC
+GTGTCGGGGCTGGCCGGATTGCCGGCTTCGTCCATCCAGCCCAGGGCGATCATCTCCGCC
+CGTGGAACATGGCGTTGCAACGGTGTGGCGATGCTGCCCGGATGCAATGCGAAGGCATGC
+ACACCCCTCTCGCGACCCAGCGCATCCAACTGGATGGCGAACAGGGCGTTGGCAGTCTTC
+GACTGCGCATAAGCCAGCCACTTGTCGTAGCCCCGTTCGAACTGCACGTCGTCCCAGCGG
+ATCGCCGAGTAGCGGTGCCCGGCGGAGGACACGGCGACCACTCGCGCGTCATCCGCGAGC
+GACGGCCACAAGAGGTTCACCAGGGCGTAGTGGCCAAGGTGATTGGTCGCGAACTGCGCT
+TCCCAGCCCGGGCCTACGCGGGTCTCGGGACAGGCCATCACACCGGCGTTGTTGATGACG
+ATATCGGCACGACGGCGCGAGGCGGAGAAGGCCTCGGCGAACCGACGCACGCTGGCCAAC
+TCGGCCAGGTCGAGCGCCTGCACCTCGACTTCGTCGAGCCCGAGCAGCGCCTCCCTTGCC
+ACATCCGGTCTGCGCGCCGTAACAATGACCCGCGCGCCCGCGTCGGCCAGCGCCTTCGTG
+GTTTCCAGGCCAAGACCGGAGTAGCCGCCGGTCACGATGGCGGTCTTTCCGGAGAGGTCT
+CGCCCCGCCATCACCTCGCTGGCCTGCGTTTTCGCTCCGAATCCCGAATTGATGGGGGTT
+TGCCTGATAGCCATGAGAACTCTCCTCGCATGCGGAAGCGGCCAGGCGGATAGCGCTGGC
+TCTTGGGACGAGGGTCATTATCGAAGTGGAAAACTGGATTCCGAATGCAGCGGAATCCAG
+TTTCCTATCGAGATCGTCCGATCCCGTAAGCAGCTGTTTCATCACCGCTGCAAGAAAAGC
+ACGGGACGGCGCAGAATTTGCTGTACGTTGGCGAACTCGCCAACAGCAGCTGAAGCAGGA
+AAAATTGATATCAACCCCAGGGCCTACTAACTAGGCAGCTGTACTAAAACTGGGGGCAGG
+TCACTCCACCGAACACTTCCGGGAAGGCATGGAACACAATGACGGAAAGCACCGCCACTG
+CGCGCAAGCCATCAATATCAGAGCGATACTTTGGTGGATAACCGTTCGACATGAGCCTGA
+CTTGTACTTGCTTGTTGAAGCCGCTCCCTCGCTTGCTCGGGAATAGGTAAAACCACAGAA
+GCTTCCGCCGCCGAGCGAAGAAAATCGATGGCTAACATCACAAATTCGCCGGCCTGCCAA
+GACGCATACATAGAAGACGGCGACCTGTCGGCCACCCTGCCCCATGTGCGTCTCTACGAC
+CAGTAGTCGCTCCGCCCAGTTCGTGGGTAACTTGCTGGCGACGCGGAAATGGCTCAGCCC
+TTGCTGAGCAGCCTGGCCACCAAACGGCGATACCCCGCCAGAAGCGAAAATCTGTCCTGG
+TAGAAATCGAGGATCATGGTTTGCCCATGAATGTCGATGGTATGCGGACCGCGTGCGTCC
+TGGAACGCCAGGTTTGCTACACGCTTCTCCGAATAATGCTCTGGATCGAGCACCTCGATT
+TCGTTTACGGCCAGACTGCTTCCATAACCATAGGAGTTGTTCTGACCGAACCGGTAAAGC
+TTTCCTCCCTCCTTGAAGATACGCCCGCCCATTCGTGCGGAGCCGGGATTCATCACCACA
+GGGTTACAGGGATGGGAAGTGTAGGGTCCTTCCAGGCTCTCGCCGACATAAAGATAAAGG
+TTGTCCGAACCTGATACCGCCTGGCCGCAGAACAGGTAGTACCTGCCCCCGTGTTCGAAA
+AGCGTGCCATCCAGAATCCGCTCACCCTCCATTCCCTGGAATAGCTTCTTGCTCTCCAGA
+GCGAAAGGAGGAGGCAGAAGACAGGGAGCGGAATGAGAGGCGACTTCCGGTATCAGATAT
+TCGACACCAGACGCCTCGAACGAATAGGGATAGGAAAAATGATTCCCCTTCAAGATCACA
+CGTGAAAAGTCAAGACTCTGGGCCTTCAATTCAATGATTTCACCCAGACCGTTGCTAGCA
+TTCAAGGCTTCGAGACGTATCAGCTTACCGTCCGCACTAAAGAAAGGATCGGCGTAGAAA
+GTATACCCCTTCTCCACCTTCGGAATCTTTCCTGCTGAGACGGACAATTCTTGCAACGAA
+GGAATATCGTTGTAAGGAAGCGCAACGACATTCCATTTTTTTTCGAAAAACGCCCCGTAC
+GATAGCCGGGCAAGCCCCCGGAAGATAGTCTTGCAGAAAAACTTGAAGACGGTGAAATTG
+CTGGGCAGACGGTAGTTTTTGCCCAGCTTTTCTAATACCACCTGCTCTCCCCGAGAGTAA
+TTGACAAGCGCCTTGCGAAGCAGCACGACCGAATTCAGATAAAAGTTTCTTGAGGTTTTC
+TTGTAGGAGTGGTGATGAACCTTGGAGTACCCGCGCACCAAGACCTCGCCGGCGTCCAGT
+TTGTTGGAGAGCTTCTGGACTATGATCCCGACGCTGTCTGCATTTTCATAGATCTCATAA
+AAGCCCGCGGGCCGCCCCCTGTAGTACTCTGGATCGCCATGGTGGTAGGAAAGAATGTCC
+AGCCTCTGCAATCCTCCATCGATGCGGAGCAGAGACATGCCAAACTTGATGACCAGCTTT
+ATTCCCTTATCCAGAATTCGGGCGCAGACATCTTCCGGGATGCGCTGCCAGGCCCCTTCG
+TAATCAGAATCGAAATGAATGACTTCTGAGCCACGAGAGTCTAACTGCACTCGACGAGTC
+ATATCATTCTTCAGGGAAAGAATATTGAGAAAATAATACCCGCAATGCTTGATGACACTT
+TTCTTGGTCGCGCTATTACGACAACTGAGAACCAATTGAATATCAAGATACTCAGAAGAG
+TCTTCAATCGCCCGCTTTTGCCACTCACTCAATGAAAGATCATCAACAATCAACGCGGCC
+TTTATTTTCATCCCGAAACTCGCCTCTGAAACAATGAAACCCCAAAAATGCTGCGAAATT
+TCGACAGCCCCGAGAAACCGACACTTTTCACTGAAAAGCTGCCATGACAATTAGCAAAGC
+ATCATTAAAGCGAAGCAGTATATCTCATGATCGACGGGCCGATTCAACCGTAAAACGGCC
+GTTAAACAGTTGCTGGACCACCAGCCAACGCTATACAGACATCATTTGGCGGAGCCACAA
+GGCTTTCGGCGGAGCCATAAAAGACAACGGCCTTACGGCCGTTGTCTTTCGGATGAATCA
+CCAGGGAAGAAGTGGCTTCACTCCCACTCGATAGTCGCCGGCGGCTTGCTCGACACGTCG
+TAGGTGACCCGGGAGATACCGGCAATCTCGTTGATGATGCGGTTCGAGACCTTCTCCAGC
+AGTTCGTAGGGCAGGTGCGCCCAGCGCGCGGTCATGAAGTCGATGGTCTCCACCGCGCGC
+AGGGCGACGACCCAGGCGTAGCGACGGCCGTCGCCGACCACGCCGACCGATTTCACTGGC
+TGGAACACCACGAACGCCTGGCTGGTCTTGTGGTACCAGTCGAAGGCGCGCAGTTCCTCG
+ATGAAGATGTGGTCGGCCTGGCGCAGCAGGTCGGCGTACTCCTTCTTCACCTCGCCGAGG
+ATGCGCACGCCCAGGCCCGGGCCGGGGAACGGGTGGCGGTAGACCATGTCGTAGGGCAGG
+CCCAGCTCCAGGCCGATCTTGCGCACTTCGTCCTTGAACAGTTCGCGCAGCGGCTCGACC
+AGTTCGAACTGCATGTCCTCCGGCAGGCCGCCGACGTTGTGGTGCGACTTGATCACGTGG
+GCCTTGCCGGTCTTGGCGCCGGCCGACTCGATCACGTCGGGGTAGATGGTGCCCTGGGCG
+AGGAACTTCACGTCCTGCAGCTTGGTGGCTTCTTCGTCGAAGACTTCGATGAAGGTGCGG
+CCGATGATCTTGCGCTTCTCTTCCGGGTCGGCGACGCCGGCCAGGCGGCCGAGGAACTTG
+TCCTCGGCGTTGGCGCGGATCACCTTCACGCCCATGTTCTCGGCGAACATGGCCATCACC
+TGGTCGCCTTCGTGCAGGCGCAGCAGGCCGTTGTCGACGAACACGCAGGTCAGTTGGTCG
+CCGATGGCCTTGTGCAGCAGCGCGGCGACCACCGAGGAGTCCACGCCGCCGGAGAGGCCT
+AGCAGGACCTTGGAGGAACCGACCTGGGCGCGCACGGTGGCGATGGCGTCGTCGACGATG
+TTCGAGGGGGTCCACAGCGCGGCGCAACCGCAGATGTCGAGGACGAAGCGCGAGAGAATG
+CGCAGGCCCTGCTTGGTGTGGGTGACTTCCGGGTGGAATTGCACGCCGTAGTAGGCGCGG
+GCATCGTCGGCCATGGCGGCGATCGGGCAGCTCGGGGTGCTGGCCAGGATGTGGAAGCCG
+GCCGGCATCTCGGTGACCTTGTCGCCGTGGCTCATCCACACGTCGAGGCCGAGCACGCCG
+TCGTCGTCCACGTGGTCCTCGATGCCGTCCAGCAGGCGCGCCTTGCCGACCACGTCGACG
+CGGGCGTAGCCGAACTCGCGCAGGTCGGAGCCCTGCACCTTGCCGCCCATCTGCTCGGCC
+ATGGTCTGCATGCCGTAGCAGATGCCGAACAGCGGCACCTTCAGGTCGAACACCGCCTGC
+GGCGCGCGCGGGCTGTCGGCTTCGTGTACCGACTCGGGGCCACCGGCGAGGATGATGCCG
+CGCGGCGCGAAGGCGATGATCGCCTCGTTGCTCATGTCGAAGGGATGGATTTCGCAATAC
+ACGCCGATCTCGCGCACGCGGCGGGCGATCAGTTGGGTGTACTGGGAGCCGAAATCGAGG
+ATCAGGATACGGTGGGCGTGAATGTCTTGGGACATGGCCATCTCTCGCTACGGAATTCGA
+AAACGACACGGGGCTGAATCGAACAGCCCCGTGCAGCACTCATTTCAATCAGCCTCAACC
+AACCCGGTAGTTGGGGGCTTCCTTGGTGATCTGGACGTCGTGGACATGGGACTCGGCCAT
+GCCCGCGCCGGTGATCCGGACGAACTGCGGCTGCGTGCGCATCTGCTGGATGTCGGCGCT
+GCCGGTGTAGCCCATGGCGGCGCGCAGGCCGCCCATCAGCTGGTGGACGATGGCGGACAG
+GGCGCCCTTGTACGGCACGCGACCCTCGATGCCTTCCGGCACCAGCTTCTCGGCGCCGGC
+GGAGGCGTCCTGGAAGTAGCGGTCGGACGAGCCCTGGGAGCCGGACATGGCGCCCAGCGA
+ACCCATGCCGCGGTAGGACTTGTAGGAACGGCCCTGGAACAGCTCGATCTCGCCCGGCGC
+TTCCTCGGTACCGGCGAACATCGAGCCCATCATCACACAGTAGGCGCCGGCGACCATGGC
+CTTGGCCAGGTCGCCGGAGAAGCGGATGCCGCCGTCGGCGATCAGCGGTACGCCGGTGCC
+TTCGAGGGCGGCGGCAACGTTGGCGATGGCGGAGATCTGCGGCACGCCGACACCGGCGAC
+GATGCGGGTGGTGCAGATCGAGCCCGGGCCGATGCCGACCTTGACCGCGTCGGCGCCAGC
+CTCGGCGAGGGCCTTGGCGGCCTCGGCGGTGGCGATGTTGCCGCCGATCACCTGGACGTC
+CGGGAAGGTCTGCTTGACCCAGCGCACACGCTCGATCACGCCCTTGGAGTGGCCGTGGGC
+GGTGTCCACCACCACCACGTCGACCCCGGCGGCGACCAGCGCGGCAACGCGCTCGCCGGT
+ATCGGCGCCGGTGCCGACGGCGGCGCCGACGCGCAGGCGGCCCTGCTCGTCCTTGGACGC
+CAGCGGGTAGGTCTTGGCCTTCTCGATGTCACGGAAGGTCACCAGGCCACGCAGGTAGAA
+GTTCTCGTCGACCACCAGCATCTTCTCGATGCGGTTCTCGTAGAGCTTGGCCTTCATCTC
+TTCCAGCGGGGTGCCTTCGCGGGCGGTGACCAGCTTGTCCTTCGGGGTCATGATCGCGGC
+GACGGTATCGCCGGCGTTCGGCTTCACCCGCAGGTCGCGACCGGTGACGATACCGACCAG
+CTCGCCCTGCTCCACCACCGGGAAACCGGAGAAGCCGTACTCGCGGGCCATCTGCAGCAG
+TTCGATGATCTTGGTCGAGGGGGTCACGGTGACCGGGTCGCGGACGATGGCCGTTTCGTG
+CTTCTTGACCTTGCGGACTTCCGCGGCCTGCTGCTCGATGCCCATGTTCTTGTGGATGAT
+GCCGATGCCGCCTTCCTGGGCCATGGCGATGGCCAGGCGGGCTTCGGTCACGGTATCCAT
+CGCGGCGGATACCAGCGGGATGTTCAGTTCGATGCCGCGGGTCAGGCGAGTTTTCAAACT
+CACGTCCTTGGGCAGGACTTCGGAATAACCGGGGATCAGAAGGACGTCGTCGAAAGTCAG
+GGCTTCTTGACTGATTCGCAGCATGGCGGGCGCTCCCAGACGGGAAAAATGGAAGCGCGA
+CATTATACCCAGCCACGGGCTTCCGCTCAACGCAGTTGATCGCCGAAAACGGCGAATGGG
+CAAATATCTTGCAAGGCGCCCGCCAGGCCCCGTTCCGCCTGTCCTATCCCGCATTTGCAG
+GATGGCAGCGCGGCGGCGGATGGCCGGATACTGCGTACGTCACCCAGCGACCGCCCAGGC
+GGCGGGACGCCGATTCCAAGAACTATAAAAGTGGGACGGGGGAGAGAATGAAAGGGAGCA
+CTGACCCGCATTCGTCATCCGCAGCCTTGCTCGCGGCGTTCGGCGCCGCCGTGCTGGACA
+TCAACCGGCTGGCGCGCGACAAGACCCTGGAGCGTTTCCATCGCACCGCGCTGGAACGTC
+TGCAGCAACTGGTGCCGTTCCAGCGTGCCTGGTGGGGCCGCGCGGCGCTGATCGACGGCG
+TGCCGGTGGAGCACAGCGCACACCTGTTCAACCTCGAAGAGCACTATGTCGAGGACTGGA
+AATCGATCAGCCACGACGACATCACCGTCGGACTGGTACA
+>NODE_1_length_40000_cov_62.8079_ID_1
+TGTTATGGCTCAAGCTGTTAAAAGAATTTATAAGGATTCAAAGCTTGCTATAGGACCTGC
+AATAAATAATGGTTTCTATTATGATTTTGATATTGAAAACTCATTATCCAATGAAGATTT
+AGATAAAATTGAAGCAGAAATGAATAAAATAATAAATGAAAATCTTAGCTTTGAAAGAAT
+CGATATTTCTAGAGACGAAGCAATAAAATTAATGGAGGAAAAGGGAGAAACATATAAAGT
+AGAACTTATTAAGGATCTTCCAGAAGCTGAAAAGATATCTTTATATAAACAGGGCGATTA
+TATAGATCTTTGCAGAGGTCCTCATATTCCATCAACAAAGTATATTAAAGCATTTAAACT
+ATTAAGCGTTGCTGGAGCATATTGGAGAGGAAATGAAAAAAATAAGATGCTTCAAAGAGT
+TTATGGAGTTGCATTTTCTAGTAAGAAAGAATTAGAATTACATTTGCATAATTTAGAAGA
+AGCAAAGAAAAGAGATCATAGAAAATTAGGAAAAGAATTAAAGTTATTCACTTTTGCAGA
+AGAAGGTCCAGGATTTCCATTTATGCTTCCTAAAGGAGTAATATTAAAAAATACCCTAAT
+AGATTTTTGGAGAAAATTACATTACGAAGATGGTTATGTTGAAATTGAAACTCCAATAAT
+GCTTAATAAGAAACTATGGGAGACTTCAGGGCATTGGTATCATTATAGAGAAAATATGTA
+TACTTCAACAATTGATGAAGAAGAATTTGCATTAAAGCCAATGAATTGCCCAGGTGGAAT
+GTTAGTTTATAAATCAGAATCACATTCATATAGAGATTTTCCAATGAGAGTTGGAGAACT
+GGGACGAGTTCATAGACATGAGCTTTCTGGAGCACTCCATGGTCTTATGAGAGTAAGAGC
+ATTCACACAAGACGATGCACATATATTTATGTTACCAGATCAAATAAAGTCAGAAATAAA
+AGGTGTTATTAATTTAATTGACAAGGTATATTCAAAATTCAGATTTAAGTACAATTTAGA
+ACTTTCTACAAGGCCAGAGGATTCAATGGGAAGCGATGAAGAATGGGAATTAGCAGAAAG
+CTCATTGAAGGGTGCCTTAGATGAATTAAATCTTGAATATAAAATAAATGAGGGTGACGG
+AGCTTTTTACGGACCTAAAATAGATTTTCATCTTGAAGATAGCATAGGCAGAACTTGGCA
+ATGTGGAACAATTCAGTTAGATTTTCAATTGCCTCAAAGGTTTGAGTTAGAGTATGTAGG
+TAGTGATGGAGAAAAGCATAGACCAATAGTAATCCATAGAGTAGTCTTTGGAAGTATAGA
+AAGATTTATAGGAATATTAATAGAACATTTTGCTGGAAAATTCCCAACATGGCTTTCTCC
+AGTTCAAGTAAAAATACTTCCTATATCAAATAAATTTAATAGCTATTCAGAAAAGATTAA
+GGATAAATTAAGCTCAGAAGGTATAAGAGTTGAAATTGATCAGAAAGATGAAAAGATAGG
+CTATAAAATAAGAGAAGCTAGAAATGAGAGGGTTCCTTACATTATTATTGTTGGAGAAAA
+GGAAGAAGCAGAAAATAATATATCATTACGCAGCAGAAGTAATGGCGATGAGGGAACATT
+AAATTTAGAAGATTTAATAGAAAGAATAAATAATGAAGTTAAAAATAAAGCTCTATAATT
+AAGTAGAGATAATACTGAAATATTAAGATATTAAATTTAAGGAATAATTAAAGTAAATAT
+CACTTTAATTATTCCTTTTAATATTGTATATGGACAACATCATCGAAATTTAAAATATTA
+TTTTAAATTTCTGCAGTTTTTAATTTATTAAACAAGCAGTTATATATTATAATGTTATAT
+ATCACTTGATGAAGGAGAAGGAAAATATGTTTTTATTTGGCGGGAATAAATTAAAGGTAA
+GAAGCGAAGAAGATGAGGATGGAGTTAAAACTTTCGTGGAATACTATGGAATGAAGAAAA
+GCGATGAATTTAAAGTAAAGGTTTTAAATGAAATGATTGGAGAAAACCTTTGTTTAATAG
+TTTTAGACTCTAGAATGTTGTATTTTGGAAATCAAGTGGAACATGAGGTGCCAGTTGAAG
+AAATAATAGAGCATTTAGGAATTTCAAGAATAGCATATAAGAAGTTTGAAATAAAGAAGG
+TACCAGAAGTATCTATGTTTGGTATTAGCATAAAAAAGGGAACTAAAAAAACTGATAAAG
+ATTATGTAATAGGATTTGTTGTAAATAAGTATAATTTTAAAAGAATTGAAGAATATGTAA
+ATAGAATGAATCTATATTATTTCATAGATAACGCTGGACTTAGTGAAGAGGATTTATTAC
+AGAAGTTGAGTGAAAATTATGAAGAAATTGATGAAATGAGTAAGGAATTTTACTGTGAGA
+TATTTAATAATAATTACATAAGTCAGTTAGTTATTTCATCAGAAAATGAGAACGCTATGG
+CAATAAAGGAAACGGTTGGCAGGTGCCATTCTGAGTTAAAATAAATAGTTTCACTCTAAG
+AAGAATGTATGCAAATTTTATTATTTATTAATTTACTAGTGAATTCAACGTCTAATAGAA
+TTAGCAAACATTCTTTTGCCTTGACAACATTATTAGATTATGGAATGATAATTAGATGTC
+GGAAAACTACTAATTGATTAATTATTTTACAAATGAAAAATTAGTTGAGATTAAAAAATG
+ATATAAATATTATCTAGATTAAATATGAGGGAGGTATAGGAATACTTTTTTGATAGAATT
+ATTTCTATGCGTTTTTTTGAAGCTTAACAAATTGCAAGTTTAATCTATATAATAGTAGCA
+TACTGAAAATTTTTTAGAAAAGGTTAATGAGTAGTATGAAGAGAATAAATGAAGCTTTTA
+GTGATTATGAATCGGCTGGCAGCATAAATACTGCCGTTATACAATCCGTAGTCTTGCGTA
+AGAAAACTAAAGTGCTGGAAATGGAAATTAGTTCAGATAATTATATTGAACTAGGGGAAA
+TTGAAAGTTTTAATAGTTTCATAAAAGATAAATTCGGATTAAATGATTCTAAAATTATTG
+TAAAGTATAGTGACGAGGTTGAAATAAGACCTATAGAAAAAGAATTGAAAAATATCGTAT
+ATTCCTTATCTACAAAGTATCCTGCATTAAAGGCAGCGGTTAATAATAGTGACTATGAAA
+TAGAAGGAAATACTATAAATTTTAATTTTAAAATTCCTGTAGCGGGTTTTCTAAAAACTA
+TGGAATATGATAAGCAAATTAATAAAGCTATAAAACATATGTATGGGAAACATTATAATA
+TCAATTTTATTGATCAAATAGATAGCGAAGAATTGGTGAAAATCGCAGAAGATAAACGTG
+CTAATGAGATGAAAGTTATTAAAGAAATAAAAATTACTCAAAGCAATAATCCTCCTGAAG
+TACCTAAAGTTGAAGAAGGTAAGGCAGAAGTAAAAGCTGAGGGCGATGGCAAAAAGGCAA
+GTAATCCATTCTTGATTTTAGGAAGAAATGCTAATATTAAGGAAAACATAATTAAAATTA
+ATGATATTACACCTGATGAAGGAAGAGTGGCTTTAGAAGGTGAAATATCAAATTTAGAAG
+CAAAAGAATTAAGAAGTGGAAAAATGCTAATTTCCTTTGATTTATATGATGGATCAAATT
+CGATGACTTGTAAGATTTTTGCAAAACCTAATGAGTATAATGAAGTGTTTTCTAGAATTA
+AAAAGGCTAAGGGTCTTAGACTTGCTGGAAATGCAGGCTATAGTAATTTCTCTCATGAAG
+TTGAACTTATTGCTAATACTGTTATTGAAACAAATGGTATAAGGAGATATAAGAGGCAGG
+ATAATTCAGAGGTGAAGAGAGTAGAGCTTCACATGCATACTCAAATGAGCCAGATGGATG
+CAATGTCTAGTGCTAGTGATTTAATTAAGAGAGCTATGAGCTGGGGAATGAAGTCTATTG
+CTATAACTGATCATGGAGTAGTTCAGTCATTTCCAGAAGCGCACAAATTGCTTGGAAGAG
+ATAATCCAGATATGAAAGTCATATATGGAGTTGAAGCTTATCTAGCTCCAGATAAAAAGC
+CATCTGTAACAAATGTTAGGGAAGAAAGTATTGATACAGTATACTGTGTTCTTGATTTAG
+AAACTACAGGTTTTTCTCCTCAGACAGAAAAGATTACTGAAATAGGAGTAATGAAAATTA
+AGGATGGTAAGGTTATAGATAAGTTCAGTACTTTTGTAAACCCTCAAAAGTCAATTCCTA
+TGAGAGTTGTAGAGGTTACAAAGATAACTGATGATATGGTAAAAAATGCAGAAACTATTG
+ATAAAGTTTTCCCTAAATTGCTTGAATTTATTGAAGGAAGTGTTTTAGTTGCACATAATG
+CTGACTTTGATATTGGATTCTTAAAGCATAATGCGAAAGTTTTAGGCTATGAGTTTGATT
+TTACCTATATAGATACTTTAGGATTAGCGCAAGATGTATTCCCTGATTATAAATCTTATA
+AGCTAGGAAGAATTGCTAAAAATCTTGGAATAAAGGTTGAAGTTGCCCATAGAGCTTTAG
+ATGATGTTGATACAACTGTTAAGGTATTTAACATAATGATTGAAAAGCTAAAAGAAAGAG
+GCGCGCAAACTTTATCAGATATAGATTTATATGCAGCCGATGAAGAAGCTAAGAAAGTGG
+CATATAAAAAGGTTAAAACTCACCATGCAATAATACTAGCAAAAAATTACGTGGGATTAA
+AGAATTTATATAAATTGGTATCATATTCTCATTTAGATTATTTTTATAAAAAGCCACGTA
+TATTAAAGAGCATGTTTAAGAAATATTCTGAAGGTTTAATTATTGGAAGTGCTTGTAGTG
+AAGGGGAATTATATCAAGCCATACTTCTTGGAAAACCAGAAGAACAAATTGAGGAAATTG
+CTAATTTCTATGATTACTTAGAAATTCAGCCTTTAGGAAATAATGATTACTTAGTAAGAC
+AGGAGCAAGTTCCAAGTAAAGAATATTTAAAAGAAATTAATAAAAAGATCGTAGAACTTG
+CAGAAAGATTAGGTAAGCCTGTAGTGGCTACTGGAGATGTTCACTTCCTAGATCCTGAAG
+ATGAAATATACAGACGTATATTAGAAGCAGGACAGGGATTTAAGGATGCAGATAATCAAG
+CACCATTATATTTAAGAACTACTGAAGAAATGCTCGATGAATTCTCTTATTTAGGAAGAA
+CAAAAGCTTATGAGGTTGTAGTTACAAATACTAATATAGTAGCAGATATGTGTGAGCAAA
+TAAGCCCTATTTCTCCTGAAAAATGTCCACCTCACATAGAAGGCTGTGAGCAGACAATAA
+AAGATATAGCTTATGAAAAAGCCCATGAACTTTATGGAGATCCACTTCCAGAAATAGTTC
+AGGCGAGACTTGATAAAGAGCTAGATTCTATTATAAAAAATGGATTCTCAGTAATGTATA
+TCATAGCTCAGAAGCTGGTATGGAAATCAAATGAAGATGGATACTTAGTAGGTTCCAGAG
+GATCTGTTGGTTCATCCTTCGTTGCAAATATGACTGGTATAACAGAAGTAAATGCGCTTC
+CACCTCATTACAGATGCCCTAAATGTAAGTATTCTGATTTTGAGGATTATGGCGTTCTAA
+ATGGCTTTGACTTGCCAGATAAAGTATGTCCTGTTTGTGGAGAAAATCTGTATAAAGATG
+GTATAGATATTCCGTTTGAAACATTCCTGGGCTTTAATGGAGATAAAGAGCCGGATATAG
+ATTTAAACTTCTCAGGGGAATATCAGGCAAAGGCCCATAGATATACAGAAGTTATCTTTG
+GAAAGGGAACAACATTTAAAGCAGGGACTATTGGTACTATAGCAGAAAAAACAGCGTTTG
+GTTATGTTAAAAAATATTATGAAGAAAAAAATATTACAATAAACAAAGCTGAAACAATAA
+GAATTTCAGTAGGGTGCACTGGTATAAAGAGAACTACAGGTCAGCATCCAGGAGGAATTA
+TAGTTGTACCAAAGGGAAGAGAAATATTTGAATTCTGCCCTGTACAGCATCCTGCGGATG
+ACCCTAACTCAGATATTATAACAACACATTTTGATTATCACTCTATTGACCAAAATCTAT
+TGAAGCTTGATATACTAGGGCACGATGATCCGACGGTTATAAGAATGCTTCAAGATATAA
+CAGGGGTTGACCCACATGAGATTCCTATGGATGACAAGGATACTATGTCCTTATTCTTCT
+CAACAAAGGCTCTTGGGGTAACTCCAAATCAGATAAATTCAGAGGTTGGAACCTTTGGAA
+TTCCTGAGTTTGGTACTAAGTTCGTAAGAGGAATGCTTGTGGATACAAAACCAAAGACTT
+TTTCAGATTTATTATGTATATCAGGACTTTCACATGGTACAGATGTATGGCTTGGAAATG
+CTAAGGACTTAATTGATAATGGAGTAATTACCAGCATAAGTGATGCGGTATGTACCAGAG
+ATGATATTATGGTTTACTTAATTAGAAAAGGACTTCCACCTAATACCGCGTTTAAAATAA
+TGGAAACTGTTCGTAAAGGTAAAGCCTTAAAAGAACCTAAATTTCCAGAATATGAAGCTA
+TGATGAGAGAACATGATGTACCAGAATGGTATATAGAGTCTTGTAAAAAGATAAAATACA
+TGTTCCCTAAAGCCCATGCAGCAGCTTATGTAATGATGGCATTTAGAATAGCATGGTTTA
+AAGTTCATATACCTCAGGCTTATTATGCAACATACTTTACTATAAGAGCAAAAGCCTTTG
+ATGCAGAATTTATGATCTTTGGAAAAGAAAAGGTTAAAGCAAAGATGCAGGAAATTCAGG
+CTCTTGGAAATGAGGCTGGTCCTAAGGATAAGGATATGTATGATGACCTTGAAATAGTTT
+TGGAAATGTATGAAAGAGGATTTAAATTCCTTCCAATTGATTTATATAAATCTAGTGCTA
+CAAAATTCCAGTTAGAAGAAGAGGGAATAAGACCGCCATTAAACAGTATAGCAGGTATGG
+GAAATGTAGCTGCAGAAGGTATAGCAAGTGCAGCAAAAGAAAAAGAATTTAATTCTGTAG
+ATGATGTAAAGAAACGTTCAAAGATTGGAAATGCTGCCATAGAGCTACTTAGAAAATTTG
+ATTGTTTAAATGGTCTTCCAGAAAGTGATCAAATGAGCTTCTTTGACGCAGTTTAGATTT
+ATGACTATAGATAAAATAACTTTGAAACTAAACTTAAGTGGTAACTTACCGAAATCATAA
+ATATTTTGTTCCGAAAAACTATGAAAATATTGCTGAAAATCCTAAGTTGCAGATTGCACC
+ACTTCAGCATGCTCCCACTTTCAGTGTGACAAGCAAAAGTGGAACAACCTACAACTAAGA
+ATTTTTAGCAGCTCATTTTCAAATGTTTTCTGCACAAATATATTTATGATTTCTAGTGAA
+GATATTACCTCAAAGTTTTAGCAAGTTTGTAAATATGTTTATATTATAGATTTAAATATT
+AATTTTGATATTATAGATAAACTAACTAAGATCTGAACTGGAGTATTCTCTCTTTATAGT
+ATGGTCTAAATTATAAGTGGAATTTAGATTTTCTAGTGAAGTTGTACTTTTATTTTATTA
+AGTATTTTAAAATTTGAACTTAAAAATTATATAAAAAATAACGTAAAAAACACAGCCTAG
+TGATTAAATATATAGGCTGTGTTTTTTGTTATATATTTATTGTTAATTTAGTTATAGTAT
+ATTTAAGTAAAATAGATTATTTTCCATTATCTGTTGAGCCAACTTGATTGTTGCCTTTAT
+CACGATTATTCTTGCCTTTCATCTTATCAACATTGCTCTTATCATTCTTATTTCTATTGT
+ATTGAGAAGATCCCATTTTATATCACCACCTTACTTTTTATTTATTATTCGCGGAAAGAG
+TTTGTGATATTCATATTGAGATTAGTTTTTCGCTCTTTTCGTAAATATTGTGGGCAAATA
+TAAAATTAGATTTTGAGCAAATAATCATTTTCTGTTTTCAAAATGCTCAATTCTAATATA
+ATAATATTTGACATTTATAACTATAAGTATATAAACTTAAAACAAATAAGGTTATATACA
+TTATATTTACAATTAGGAGGAATAGATTATGGCAAAACTATTAGATAATGAATATTCAAT
+GGTATCATTTAAGGCTCGTAAAGGAGATAAGGAAGCCAGGAGAAACACAATTATAAATAT
+TATATTAAATATTTTTGTATTAGAAGGTAAAGGTAGCAGTGGTACTAAGGAATTTATGTT
+TACACTTACAAATAATCATCTATACATAGATGATATTGGGTACGATTTAACTGGTCAGGT
+AGACATCTATCTCACAGAAAAATTTGATAGAAAAGATATAAAATCTTTTAAGGTTAGAAA
+AGAAGGCAATAAAGAAATAATCTCTCTTGTAACCACTAATGGCAAAACTGTAACTTATGT
+AAGGGACAATGAAAACGCTTCAGATTTAGCAACAGAAATGGCTAAACTAATAATTGAAAA
+TGCAGGAAATTAAATAATATTCAATAGTCAAAGGGGGTGCTTAGATAACTCCCTTTTAAA
+TATTGTTATATTTTTCACTATAATACATTAATAGGGTGTAAATCCTTAATAATTATTGAT
+TTATTCATTGCGAGTACGTTTGTCAGTAAAGTTTTCTTCAACTCAACTTTATCAAGTGAT
+TTATTTAGTTCAAGAAATCTATGCCAAAATAAATAATTATCCATATATTTAGTTGATACA
+CCATTAAAGTGAAGATTAATCCACTTTCCAAGCCTTTTATGATATTCATTAACATGTTGC
+ATATGATATAATTTTTCGATTACATATTGTTTTTTAGAAGCATTTACTTGCTTATGCTCT
+AAACCCTTCATTTTTGCAAATGATAAATAATTCTTTGCCGAGTCACTTATTAATAAAGCA
+TTAGGGGCAATATAATTGCCTATGACATTATCTATTTGTGTAGCAGTAATACGCCCCATA
+CCAGCATTTCTACTAATTATGTGACCATTTCTATCCATAGCAACTAAAATACAAACCTGT
+TCATGGCTTATGCCTCTAAATTTAGATTTACCACCTCTTTTGTTGGGTTTGCGAGTTTTA
+CATTGGTTTTTCCCTTTAAATGGCTCTATGAAGAAGGTTTCATCTGACTCAATGATACCA
+GACAATTGTTCTATATCCATTGAACGTAAAGAATTAAGCACTTTATGTCTCCAATAAAAG
+GCTGTTGAAATACTTATATTAAGAGCCTTTGCGATTTTGGGTAGAGTTGTTCCCTCTGAT
+ATAAATTGAAAATATTTAGCCCATTTTTGAGGATAATGTGTTCCTGCCATTGGACTACAA
+GATACATCATTAAAGGTTTTGCCACAATCTTTACATTTATAACGTTGTCGGCTACGATAT
+TTTCCATGACCAATAATATGTTCACTATTACAATGAGGACAAAACGTACCCTTTGAAAAA
+CGTGTTTCTCTAATGGTTTCTATATAATCATTAACTCTATCAGAACTGTTCTTAACAAGA
+GGATATATCAAGTTGAAAAACATATTTTGAACCACTGGTGATAACTTTTGAAATTCATCA
+AATAAGATATTTATATCCATGAATGATATTCACTTCCAGAGCTGGTAAACTCAATAAAGT
+CATCTGACAGCATATCATTTATTTTATCTTCTGACTTTCTAACTTCTGATTTTAATAACT
+CATGTTCTAATTGTAATAGGTGATCTTTAATACTATTCGTGCATTCACCTCATCTTATGA
+TATATATTTCAATATCAATCTTTCTATCAATAATGTTATTAATAATGAGTATTTAAATAA
+TTTGCTATTTCTTCAATAAGTTCATTTCTATCTAAATCCAAAGCCATGATTGAGCAGCCA
+TCCATATGATCGCAAGAGATATTGATTTTTAGTAATAGGAATTAAATTATGAAGAGGATT
+AAGACAAGTTTAGAATACATTTTTGTAAGTTCATAAGTATTGAAAAAGTAAACTATGATT
+TTTAGTTGTAATAATTTTAAAAAATAGGTTTACAATTTGAACTTAAAAATACTTAGAGTG
+TATATAAAGTAAAAATTTTCATGTTAAATTTTATATTCCAGATGAATTTAGTTAAACTTA
+CCCCCACAAGGGGCACAATGTAGCCACAAGGTGAAAATGTCTGAGGATATATGTTATTAG
+CTGGTACTCCTCAGAAGTGATTGGAGTATTAGAATGGCTATATATCAGATGGATGTACAT
+CCATGAGATTGATGCCCTCATGGAAAGATTAAAAAGGTTTAAAGTATTTCTTTTAAAGGA
+GAGTGAGAAACATGTCAGATATTAAATGGATTAAGTTATCTACTAACATGCATGATGATG
+AAAAGATGAAATTAGTAGATGCAATGCCAGAGAGATACTATTCATTATTTATGGATAAGA
+TTACTTATACAAGCTGGCAAAACTAATGATAATGGACTTATATATCTAAATGAGAATATC
+CCATATACTGATGAAATGTTGTCTACAATATTCTCAAGGCCTCTAGCTTCTATTAGACTT
+GCACTTAAAGTATTATCAGATTTTCAAATGATTGAAATAGCTGAAAATAACGTAATTAGA
+ATAGTGAATTGGGAGAAACACCAAAATGTTGAGGGAATGGACAGAGTTAGAGAGCAAAAT
+AGAAAAAGAGTTCAAAACCATAGAGAAAAGAAAAAACAACTTGAAGCTGTAGTTAATGAA
+AGTGAAGAAACTAGTGTTGAAATTGAAGAACATAGCTTTGCTGAAATTGAAAAATATAGT
+ATTGAAGTTACAAATGATATTTGTGATACTTCAAAAAAATCTTGTAGCGTTACAGATGAT
+AAAAATAACGTTACTGTAACGGTGCAGAATAAGAGAGAGAATAAGAACAAGATTAAGAAT
+GAGAATAATAAAGATAGAGAGATAAAGAAAGAAGAGAATACAGGTTATGATGCAAATGAA
+ACTCCTACTTCTAATGCAGCGTACGTAAGTGATTTGCACAACAGACAAGCTTTTAGATCT
+CTGGTTAAGGAAACTTATATTCCTAATGCCATGGCAGTAAGTGATCCACATGAAACCACA
+GATTTTAGTTCTCTGCTTAAATCAGAATCAGCAAAGTCTTCTATCTCTCAATCTAAAGAC
+TCAATTGCTGAGCAGGATAATAATTTAGAGGACATAAACTCTAAATCCATTGAACTTGCT
+AAGTATTGTGAACTAATAGCTGGAATACCTAATGTTCTTAATTTAGGCGCACTTAGGTTA
+GCTATAGGAATGCATGGTCAAGAATATGTAAAGATGGCTATAGATATAGCATTAAAAGCC
+AATAAACCTAATATGACCTACATTGATGGCATACTGAAAAATTGGAGAAGAGAAGAATAT
+CCAGATGACAAGGAGGTAAACAAAAATGTCAATAGGAGCTATGGAAAGAATAGCAACTCA
+GATAAAAACAAATTTGCAGGATTCAAACCAAAGGAAACACGACGAAGCCTTACAGATGAG
+CAACGAAAGAAAGCTCTAGAAAACCTCATATAAGTGTGAGAAGTATTGAAATACTTCTTA
+GAAGAAAAGACAAGAGTAATTCAAGGCAAGAAATCATCTCAATATATTGTGGTTATGATG
+GCTTAGTAAATATATAAAATTTGAGATATACAAGAAATGATTTAATCATATAAAAGAAAA
+TAATTTTGTATAGGGGAATGTAAAAATGAGAGCATCAGGAATAGTGAGAAAGCTTGATCC
+ACTTGGAAGGATTGTAATACCAAAAGAAATAAGAAAGGTACTTGGAATTAATGATGGAGA
+TTCTATGGAAATAATTAAAGTTGATAATGAGGTAGTTGTTAGGAAATATAGTAAAGGCTG
+CATATTTTGTGGAAATGATAAAGGGGTTTTTAACTTTAAAGATATACTGATTTGTAACGA
+GTGTAGGGAGGCATTAAAGGGAAATTAATTGAGAAAATTTAAGATGAGTTGATTAAGCTA
+AGCCATTAAATTTAAATTTTGAATATGTAAAGTTGACTTAGTAATAAATAAAAAAGATGG
+TCTTTGAAAATTTAATAATTCGATATTTACAGTTTATGCTATAATTGATTTATATTAGAA
+AAAGGCATGTGTTAAATAAAATAAATCGGAGAAGTAAAATGAAGAGATTAAAATTAAAAA
+AAGTAATATCTAGTTCATTATTAGTAATTTTAGTATTTGTATTAAATCCAATAGTTGTAA
+GTGCTGAATGGAAACAAGATTCTAATGGATGGTGGAATGCAGAAGGAAATTCATGGTCAG
+TAGGTTGGAAAGAGATTGATGGAAAGTGGTACTATTTTGGACAAGATGGATATATGAAAA
+TGGGATGGATACAGTATGAAGATAAGTGGTATTACTTAGGTGATGATGGTGCTATGCTTA
+AAAATACTACTATTAACGGTTACAAATTAGATTCTGACGGAGTGTGGATTCAATCATCAC
+AAAATGATTCATCAAATGTTGAGTCGAAAGATAAGAATGTAAGTTATGAAACCGAAGTAA
+GTAATAGAAAGCCAATTATCAAAGATGGAAACTATCTATATGAATCTGGTAATTTATCCA
+AAGTTAATATTGATGGAACAAATAAAACATACTTTGAGCAGGCATATGGAAGCATTATTG
+GCGTTTCTGATGGCTGGGTTTACTATGTTGATGGAAATACTGAACACCATGGCAGTAAAG
+GTATATACAAAATAAAGGATAATGAGAAAGTTAAGTTAACAAGTGAGGATTATATTGTTG
+ATGCTGTCTTTTATAAAGGATCAATATATTATGCATTAGGACCTGAAATGGTTGAAAATA
+ATGTGGTTAAGGGTGGATTATATAAAGTTGATATTGATGGAAAAAATAAAGTTCAACTTT
+CTGATCAGTTGGTTGAGAATATAAATATATATAAAGATTGCATATATTACAGCGGTACAA
+GCTCTGTTACTACTGATAATACAGTTAGCAACGAGAATTCAGGTATATTTAAAATGAACA
+CTGATGGCACAAGCAGAACAAAAATCAGTGATCATTATGCTTCATTCTTAAAATTAAGTG
+GTAATAATATTTATTTTAGCAGTTTTGATTATAACTACAAATTATATAAGATTAGTATTG
+ATGGGACAAATGAAAGAAAATTAAATGATGATATCAGCTGGGATATTCAAGTGGATGGAA
+ATTGGGTATACTATAGTAATAATCCTTACGATGGGCATACTGATATGATTCTACCACTTG
+ATAAGATGAGAGGAAATATTTATAAAATTACTATTGATGGAATGAATAGAACTAAGATTA
+ATAGTGAGGCAAGTAGGTTATCTGAAGTATTAGATGGGTGGATATATTATAATAATTGGT
+CCGATAATAAATCTTATAAAATGAAATTAGATGGTAGCAATAAATCAGTTGTGGAATATT
+AGTATTATTATAATAATTCCGCTAAATAATTGATTATGTTTTATTATAGTGTTGAAATAC
+AGCCTAAAATATATACATGGAATTGTTTATTATAATACTCAATATTCAAACAGTATAAAT
+CACTAAAAATAAATAGTAAATTGTAAAATCGTATTATTCAAGAAATTGAATTTGCGATTT
+TTTTTATTCTCAAAGAGATTATATTATTGGACAACTGTGTGGACATTGTGCCCCTTGAGG
+GTATAACCTATGAAAATAGTTATTTTATTTTTGAAAAAATATATGCTGCAATTCATAGTG
+AATAATTATGGATTAAATAATTGTAAAATTTTTAAAATTTACAATGAAGAATTATTTGAA
+GAATTATTTTGGGAACATATATATAAAATCTATAAAAAGGGGATAAACAAAATGGAAGGG
+TTACGAATTTTTAAAGATGAAAGATTTGGAGAAATAAGAGGGTTAAAAATTAATAATAAA
+GATTATGCAGTTGGAATTGATATAGCAAAAGCTTTGGGATACAAAAACCCAAGAGATGCA
+ATTTTAAGGCATTGCAAGGGTGTCGTGAAACACGACATAGGGGTAGTTACTGGAAAGAGG
+AGAGATGGAACAGAGGTTATTCAAAATATAGAAATGAGTGTAATTCCTGAAGGGGATATT
+TACAGGTTAGCAGCCAAATCAGAATTACCTGTGGCAGAGAAATTTGAAGCATGGATTTTT
+GATGAAGTATTACCTAGCATACGAAAAACAGGGATGTATGCTACAGATGAATTATTAGAT
+AATCCTGACTTACTTATTGCTGCAGCGACTAAGTTAAAAGAAGAGAGAAAAGCAAGGCTA
+GAGGCTGAAAATAAAGTGAAATTATTAGAACCTAAAGGACAATTTTATGATGATGTCGCA
+GGATCTAAAGATAGCATTGAAGTGGGACATGTTGCAAAGGTTCTTGCTATAAGAGGAATG
+GGAAGAAATAATTTATTCTCACTCTTAAGAGAAAAGAAAGTTTTGGATAAAAACAATATT
+CCTTATCAACAGTTTGTAGATTTAGGCTATTTTAGAGTATTGGAGCAGAAATACACAGTA
+CCTAGTGGTGAAACAAAGATAAACATTAAAACAATGGTATTTCAAAAGGGGATAGAGTTT
+ATAAGGAGAAAAATTGGAGAGTAATAAACCCCATTCTCCTTATTTTAGGATATGCAAATA
+TAAGAGCTTGAATATTTACATATATTTAATATAAAGCACCATGAAATTTATTAATATAAA
+TTATATTTTAAATTTTAAAAGCAGTAGTTAGGAAGCCTTTAACTACTGCTTTTTATATTA
+AAAGATAAATATGAAAGGTGATAATAATTTTTTCTTATTCATGACAAAAAAATAATATGC
+ATGGGAAAAAATGCAGAATATATTAATTAATATATTCTGGTTAAAAAATCTAAACTTAGT
+ACTGAAAAATTTACATTTAATGTGTGGATTTGGACGTTTAGAGAAAATGCTATTTAATTA
+ATATGAGTATTATGAGAATATGTAATTGTAAATATAAAGAATGGAAGTGAAGTTGATTTA
+TGTCAAAAGTACTTTTTTTAAGTATACCTGCACATGGTCATATAAATCCTACATTAGGAT
+TAATAAATGAATTAGTAAAACAAGGAGAAGAAATTACATATTTCTGCTCAGAAGATTTTA
+AAGAAAAAATTGAAAAAACAGGTGCCAAATTTAAAAGTTATAGAGTGGAACTGAGCCTTT
+TTAAAAGAAAACATAAGACTTCTAATGATATGGGGCCAGATAAACTTCTTGATTATATAA
+ATGAAACGCTTAAATCAAGTGATAAAATTATAAAAGATATTTTAAATCAAATTGAAGGCG
+AAAAATTCGATTATATTATGTATACAGCCATGTTTCCTTTTGGAAGTATCATTGCTCAAA
+TACTGAAAATACCTTCAGTTTCTTCCTTTGCAGTGTTTGCAACTCCTAAAGAATTAAGGT
+CGCAGCACAAAGAATTAATGAGTGAAAATTTAATAAAAAATCATCCAGTTATAGAGACTT
+ATAAAAAAGTTTCAAGACAATTAAAAGCAGAATTTAATGTGGAAATGTCCCATAATATCT
+TTGATTTATTTTTTAATAAGGGTGATATAAATATTGCATATACTTCTAAATATTTTGTTG
+CACATCCAGAATATTATGATGATAGCTTTAAATTTATAGGGCCACCAATATATGATAGAA
+AAGAAAATTTAGATTTTCCTTTTGAAAAATTAGAAGGAAAGAAAGTTGTTTATATTTCAC
+TAGGTACAGTGTTTAATAATACAGACAGCAATCTCTATGATATATTCTTTAAAACATTTG
+GTAATACCGATGAAGTTGTTGTAATGGCAGCATACAATGTAGACCTATCTGAATTTGATA
+TACCTAATAACTTTATTGTAAGAAACTATGTTCCTCAATCAGAGGTTTTAAAGCATACTG
+ATGTAGCAATAACTCATGCAGGAATGAACAGTACCAGTGACTTATTGTATAACAATGTGC
+CTTTTGTAGCAATACCTATAGGTGCGGATCAACCATATATGGCAAAAAGAGCTGAAGAGT
+TAGGTGCAACTATTTCTCTTGATAAAGATAATATTACTCCAGAGATTTTAAGGGAATCTG
+TTGAGAAAGTTTTAACTGATCCAAGTTATCTTGAAAATATGAGAAAAATAAGTGATTCTT
+TTAAAGAATCTGGTGGTTATAAAAAAGCAGTTGAAGAAATTTTTAAATTAAAACGAGATA
+AGATAGATCAATAAGATTTGTTAATACTAATGCATGAAAAAATAAAAGTTGCAATAAAGG
+TAGATTAGGTAAAAATACTTAGTCTGCCTTTTACTATGTATGTGGAAAAATCTTTGGAGC
+AAAGGGTTTCCTTTTTAAGAAGAACTTGTAATACGGAATACTCAAGAAAGCTATGAACGT
+TCTTATTATTCATGTTTACTATGCAAGCAGAAAGTAGATTGATTATTATCGCAAATTCCA
+AGTTGTAGTTAAATTATTTCAAATATACCTAATAAAGAAAATATTTAAGAGATTTGTAAT
+GTAGCAGCATGATAAGTGCTGTTACATTTATTTTTTGCAGAAGTAGATAATTATTTTGTA
+CATGAAAAAATTGTATTATAATGATATATATGGATCTATAGATAATAATAAGATTTTATT
+CTTATAACGTCTATAAAAGGAAGCGAGAGAGCTTCAAAAGATGTGTGTTAAATTAAAATG
+ATAATTAATAAAATCAGTTGTATAAAAAAATGTGATTTGTGAGTAGATAAAATACTTTAT
+TTTGTAAGCTAAAAAACAATTAAAATAAAAGTGGTGAAAATATGAAAATATCTATTGAGG
+AAATTGGAAGAGAATTTGAAGAAGAAATTATTGTTAAATGTCATGAGGTTAATGATGATA
+TTTTAAAATTAATAAGCAAATTAAAAACAGAAAAAGCTGTGGTTCTTGGTTATGATGGAT
+GTAATATTCACAGGATTCGTATTTCAGATGTGTATTATTTTGAGGCAGTAGACAACAAAG
+TATTTATCTACTGCAAAGACAAGGTGTTTGAGTCTAAGCAAAAGCTTTATGAATTGGAGG
+AAATGTGTCAAGGAAAAAAGTTTTTCAGAGCATCCAAGTCGACTATTATAAACATGACAA
+AAGTATTATCAGTACGACCATCTTTAAGTGGCAGGTTTGAATCAAAGCTGGATAATGGAG
+AAAAGGTAGTTATCTCTAGACAGTTTGTACCTATATTAAAAGAAAGGTTAGGTTTATAGG
+AGGAAATAGCATATGGAATTAATGGATTATATAAAAAAGTTAATAAGAAATTATTTTACT
+ATATTTTCACTTATAGTAATATGTGTAACAGTATCAAGTCAGATTTTTTTACCAAATAAA
+TCATTAGAATTAAAAGATATATATATTTATATGATATGCTCATTAATCATTGATTTGCTG
+AGCCTAATATTATATTCCACAGAAAAATTATCAGAAAAGCAAATGTGGATAAGGAGAATT
+ATTCACTTTATTATACTCAATGGAGTGCTATTAATTTTTACTAATGTGATTGGATTTATG
+CATGATGCTTTAGATATAATTATATTAGAAATTCAGATAATAGTGATATATGCTATATTT
+CAATTTTTAGTATGGATGTACGATAAGAAGGACGCTAATGAAATTAATGAAAAATTAAAT
+ATAATGAGAGAAGAATTAGAGATTAAGAAGGAAGAAGAATAAAATGTAATTTTCAGCTTA
+CCTCTTCTATTTTACAACTTACATGTCGTTAGTTACAGGATACTGCTTAAGCTATGTACA
+TTTGGCTTAGTAAGTATTATTTTAGTTTTGTAGATGAAGTATGAAATTAAAGTATACTTT
+TAAGATTAAGGCTGGTTGTAATTAAAAGAATAAATTGAAGAGGTGGAGGAAGAATGGGAA
+TAATAGTAGTTTCTATTGCAGCAGTTATAGAAATTGTTTTTGGAATATACTGCTTTAAGA
+CAAAATCAAATCAGAAGAAAATAAGAAGTTTAATTCACATTAGTGTATTTATAGCATTTG
+TTGTATTTACATTTCTATCAGTAATACAATGGAGTTTCCGGTGGATGCTTTTGGGTGGGG
+TATTGCTTATTTTTGCAATTACTTCGGTAATATCACTTATACTAAAAAGGGAAGATAAGA
+AAAAATACAAAATTAGAAAAATGGTTGGTAAGTCTATCGCAATGTGCATAGTTGTAGTTT
+TAGCTGTCAGTCCTGAATTAATCTTTCCACAGCATAAGATGCCTGAATTAACAGGAAAGT
+ACAAAGAGATAAAAACGGCAACTTATACATTCAAGGACAATAATCGTATTGATATATATA
+GCCCCAAAGGTGAAAATAGAGAAGTTACAGTAGAATTTTGGTATCCAGAAGATGATGAAG
+TCACATCTCATTATCCTCTTGTAGTATTTTCCCATGGTGCATACGGAATGAAAACTAGTA
+ACATGTCTACTTTTAGAGAGCTAGCTAGTAATGGATATGTGGTCTGCTCAATAGATCACC
+CATATCAATGTTTATTTACCAGAGATGCTGATGGAAAGATAACAACAATAGATAAATCAT
+TCATGGACGAGCTTAATGGTGCAAATAATGGAGCTTATGATGAAGAGACTGAATATAATC
+TTGGAGTAAAATGGTTAAATGTACGCACCGAAGATATGAATTTTGTACTTGATACAATTA
+TTAAGAACGTAAAGGAAGGTAATACAGAAAAAGTTTATAGTCTTATTGATGCTGGTAAAA
+TTGGATTAATAGGTCATTCATTAGGAGCTTCAGCAAGTGCACAGCTTGGAAGAGAACGCA
+GTGATGTAAGTGCTGTAGTTAATCTTGATGATGACTTAATAGGAGAATACACTGGTTTTA
+ATAATGGCAAGTTGCAAATTAATCATAATATTTATCCTATACCCATTCTTAGCATTTACA
+GTGATGATTTAAAGCGAATATATGAAAAAACTGATCCAAGCATTATACCTCAAAAATTAA
+TTTCAGCGACTGCTTTAAAGTCCTTTGAAGTATATTTTGATGGAACAAATCACATGAGTT
+TTACTGATCTTCCATTAGCATCTCCAATTCTTACAAAATTGTTATGCAATACAGCAAACA
+GTAAGATTGGTATACAAAAAGCAGACAAGTACTATGTAATAGAGAAGATGAATAATTTAG
+TATTGCAGTTCTTTAACTGTTATCTTAAGAATGAAGGAGATTTTCGACCAGAAGATAAAT
+ATTAAATCGTAGTAGTAAAATCTAATTTTGAATAGCATGGCAATGAAAAAAGCGCTATCA
+TGTGCTATTGATATGGTGAATATTATAAAAAAATATAAGTTGTAATTTAATGAGGTGGAG
+AGATGAAGGTTTTAGGAATTAATGGTAGTTCAAGAAAAGATGGAAATACAGCATTGATTA
+TGAAGATTGTTTTTGATGAATTAGAAAAAGAAGGAATTGAGACGAAAATAGTTCAATTCT
+CTGGTAATATAATTGAGCCTTGTAAGGGGTGCTTTGCATGTAAAGGAAAGAATAATTGTG
+TTTTTAAGAAAGACATATTTTATGAATGTTTTGAAAAAATGAAGTTAGCAGACGGAATTC
+TTTTGAGTTCTCCAGTCTATTCAGCAGATGTAACAGCAAATATGAAAGCTTTTTTAGAAA
+GGGCAGGGGTTGTTGTTGCAACAAATCCAGGTCTACTTAAACATAAGGTTGGTGCATCTA
+TATCTGCTGTTCGCAGAGCTGGAGGTATGACAGCAGTAGATACAATGAATCATTTTTTAT
+TAAACAAAGAAGTTGTTATAGCTGGTTCTACATATTGGAATATGGTTTATGGAAAAGATG
+TAGGCGATATATTTAAAGATGAAGAAGGAATCAATAATATGCATAATTTGGGACAAAATA
+TGGCGTGGCTGCTAAAGAAGATTAATTAATGCTATTAACAGGATCTAAAATGGTATTTCA
+AAAGGGAATAAAGTTTATAAGAAGAAAAATTAATAATAAATAAAGTTGTCGTAAGCATGA
+AAATAATTAATATATATTGCAAAAATAATCCTTCATCATAATTCCAAAAATATTACAAGA
+ATTTTAGCTGTAATTGTGAAATGTGAATTGCAACATATATATACTATTTTCATGCTTATA
+TTTATAAATTAAATGGGAATTCGTCATGAGAGGAATTATATTAGGTTTGAAAATTGCGGT
+GTGTAAAGAGGAAAATCAATAGTGTGTGTAAAATATATATAAGTAAAGGAAAAAGTATCA
+ATCATTTAGGGGAGACGTACTTATGACGAGAGAAAGTAATTTTGAATATGTAAAGGGGAC
+AGATATAGAAGAATGCTACGAAAATTTAAAGAAGGCGGAATTTGTATATCAAAGTTTTCC
+TGATGCAACAATTATGTGTTTAAGATCAATAGCGGAAACTGTTTTAATAAAAGTCAGGAA
+TGAATTTTACAAAAGTGCAGATAATAGTGGAACTTATTATGGAATAATGGGTGAACTCAT
+AACTGTTTCTGAAGTAAAGTTCTCAAAAGTGTATAGAGAATTTAATATTATAAGACTTAA
+TGGGAATTATGTACTTCATCCTGAGGCTGTAATAGAAGAAGAAACAAAAAGGACGCCCAC
+TGAACTTTTAGAGATTATGCATAACATTCTTATCTGGTATCTTCAAGATATAAAAAATAA
+AAGTTCTATTGATAGTAGTAAAATCAAGTTTATAAATCCAAATAATTTTAATAATGAAAA
+AAAAGAATTAACTGAGGTAAAAAAGAAGATTTCAGAAAAGAATAAGAAAATATCTGAATT
+GAAATTAAAGATAAAGCAGCTTAAGGATTCAGAGAAGGATAAGGCTGATCAGTTATTTAA
+GTTAAACAAAGAAATAGATAATATAAATGTGGAAAGACTTGAATTAAAAGAAAAAGATGA
+GTTATTAGAAAAGAAGATTAAAGAGCATGATAAAGAAATAGAGACTATAAAAAAGAAATA
+TAAAATTGATCTCCAAGAAAAAATTGAGAAATTTAAAAAGGAACATAGAGAATCTGAAAA
+AGCTTCTAATGAGGCTGAATTAGCAGCAGTTAAGAATGAAATTTTAATAAAGAATAATGA
+AATAGCAGAATTAAAAAGTAAGATAGATGATTTCAAAGAAGAATCTAAGGATAAATTAGA
+ATTACAAAAGGAAATTGAAAAAATAAAAGCTGAAAAAGAAAAACTAGAATCAATGGATTC
+TATTTTAACTAAAGGGATTAAAGAGTATGATATTGAGGTAAAAAGAATTAAGGAGCAGCA
+CAAAAGGGACTTAGATGACAAAATTAATGAGTTAAAAAGTAAAGAAGATACATATTTAAA
+AGAAAAAGAAGAATTAAATAATATTAGACAAAAAATACATTCAAAAGAAAATGAAATAAA
+TGAACTAAAAGCAAAAGTAGATGAGTTAAGGCAACAGTCTAAAGAAATAAATTTACTTAA
+AATAAGTATAGATGATTTGCAAAGTGAAAAAGGTTATTTAGAAAATCGTGATAGAATATT
+AACTAATACGATTCTTGAAAAGAATAAAGAACTAGAAAATATAAAAGAAGCTTATAAAGC
+TAATGTTGAAAAGATTGAAATATTACGTAAAGAGCGTAATGAATCAAATGCGTCTCTTAA
+AAATAAGGAAGAAAAGCTTATTAAGGTTGAAAAAGAGAACTTTGAACTAAAAAAACAACT
+TAAGGAAATAGAAGAAACAGCTAAAATTGAAGCTATAAAGAGAGATGAAGAGTTAAAGAG
+AAAAGAAAAAGAGCTGCATGAAGGGATAGAAAAATTAAGACAAGCTTATAAAAATTCTTT
+TGAATTAACCAGGGAGTATCAAGATGTTCTAGAAAAAAGTGAGTATTCTTATGATAAAGA
+AGAAGAAAGATTATTAAATATTCAAAAGACAGATGTTAAAGAAAAATTAGTTGAAGAGGA
+TAAGAGCTTTCATAATAATTTAAATGAATATAGTGAGGGCGTGAAAGAAACTAATGAAAG
+AATAAGAACCTTCAAGAAGGTATTAAAAGAGAAGAGCATTAAGGAAGGTAAACACGTAGC
+ATTTTATAGAGGCTTTTTAGGATTAGAAGCAGAGCAACTTAGAATTTTATATACAATGCT
+TACTAAGACCAATATTTCCTCAATTTTAATTAGTAAGTCTAAGGAATTACTATCACAATC
+TAATGAAGATAAGTTCATGGAATTTATACATAAAAAAGCACGAGAATTGAATCATTTATC
+AGATGAGGAAGTAAGATTAAAAATTTATTATAGATTAATTAAATTAACTGATATTGAATA
+TAAAAACATTTATGAAAGAAGAAGTTTTGTTGAAACTTTAGATGAAATAGTAAATGCAGG
+ATATTCAATATTAGAAGGAAAAAAAGATTTCAAAGGTGGAGGCTCAAAGTTAGAAGCCAT
+AGGTACATATTATTTAGAAAAAGTACTAGAGGATTTTAAAAATAAATATGATAGTGGAGA
+TATAAAAGTACAGCAGGAATTAATTGATAACATTTATAATAATTTTCAAAGGTTAAGTGA
+AAAAGCTAAAAAAGAAATTTATGACGAGTTACATTTGAAAAGTACTTCTGAAAGTACAGT
+TAAAGCAGCCATAAGATCAGCCCCCTTTGTATTTTTATCTACTACTATAACTGTTGGGGG
+ATTTTCAGCATTTAGTGCAGTTTCAAGTATAATTTTCGGAATTTCACATTTACTAGGAAC
+AACTTTTTCATATGGGGTATATACTGGGGCTTCATCATTATTAAGCTTTTTCAGCGGGCC
+TTTTATGGTAATACTTTTTATTGTAAATGGAGGATTTTTGCTTACTCAACATAAAAAACA
+GCAATTAGAGTTAGTACCTTTATTTATAATGCAAACCATAATTACTAATGTAGCTATAGA
+AAAAACAAAAATAAACTTTGATAACTATGATACTATGATTGAATTATGGAAAAGAGAAAA
+AGGGAATTTTGACAAAATTACCATACAAAAAAGATTGCAGGAAAATATCTTAAATAATTA
+TACAAAAGAAAGAGATGAACTTGCTGCTAAATCAGAACAAGTGTCTAGAGCTATTAATAC
+ATTATGGGAAGAACATGCAAAATATAATTATAAGTTTAAAGATATTGTGTTAAGCTCTGA
+TAAAAAAGTATATCTAAACTCATATGCGGAGTATAGCAGTACTATAAATAAACTGGAAAT
+GGTTCAAAAAGAAATAGATGAAACTAAAAACAAGGTAGGAACCTTAAAAAGCATATTTAG
+TTTAGATATGTGGAAAGGGCAATCTTCAAAGCTTGTAAATGAAATGAACATAATAAATAT
+GGAAAAGTCATTAGTTGAAGAAGCAAAACAAAGCCAATACTTTAAGGAAGAAAGTGCTTT
+ATTTTCAGAATTGCAGCAAAAGATAGATGTATTAAATGAAATTCAAAATAAAACTAAAGA
+AAAGATAAAAGATAAAAGATAAAAATAACCTAATCAGCGTTTTGAAAAATAAAGTTAACT
+TACTCGAAAATGATTTGGTTAAAATAAATTCAGAATATCCAGATATAAATAACGCTGAAT
+TTAGGGCAATTGGATAGTCAGGATAAGGATAGCAAATTCATTTATTTGGGCTATAATAAA
+TATAGATGTGGAGTAATACAGTCAGAATCTAATTACTTTTGTATGTTTCCAAGACAAGCT
+CGTGATATGCAGAAATAGAACAACCTTGTAAAAATACACCTTAACTTTTAAGAAGTTTCA
+TAAATTTAAGGACTGCAATAAGATAAAAAATATCAATCTTATTGCAGTCCTTATTTTTAA
+GCTACTTCATATTTAGTAACTTGTCTTTGAGTAACCTGAGCACCGGATTTCTTAACTAGA
+TCGCCAGCCTTAGTTTTAAAAACATTTTTTGAAATTATAGTGTCCATAAGTGCGTTAACT
+TCATCTTTTGTAAGAGTAGTTTTAACACCAGAAACACTTAAAGTGCTTTTTTCACCAGCA
+GAAGTTAAAAAAGTCATAGCTAAAGTATATTCCATTTAATTCACCACCTTTCATTAAGTT
+TAGAGTTAAGGAAACTACTCCTACTCCTATAGTTTTAGGAGTACTCACAGAGTAAGAGAT
+CATTATCAAATCATAGATGCCTACAGGGAAAGTTCGAAGAGCGAAATATAAAATGCTCAT
+AGAGAAAGTTCTGCTTACCAAATGTAAAATTTGGAGCATCACTTTTCGGTTCTCACTTTT
+GATATGCCTGCTTAACCGATTTAACTAAGTTCGAGAAGTCCAATCATAGATTTGGACTCT
+CACTCTTATCTCACTTATCTGCTTAAGCATTTGCTAAACTAGAAGATTCATTAATAAAGT
+AATCTCTAGTGTTAGCTTCTAATACACCTTTAATTGCATCTGCAATAGCATAGACATTTT
+CAGGTGTAGCATCTGTTTTGATACCTGAGAAAGTTTTCTTGGTATAAATTGGGTCTCCAG
+CCTTGTCTAGACCTTTTTGAACCTCAATACTAAGAGAAGCAGAGTCAATAGTTTTTGTTA
+CAGCCATGTTTCATTACCTCCTTTACTTTGTTTTCATAAAGGATATATGGATGAATTTTA
+TTTATTACATAAATAGATGAAAATTATTTGTCAATTTAGCACTATGCTGTTAGATGGATG
+AGTTCTATTAGTGGCAAGAATCATTTATGCCGTATGAGCCATGAAGTATTGCAAAAAAAC
+ACATGATTCTTAGTGAAGAATTAGAGAAGATAGAGGTTAATAATGCTAGTGATAAAGAAA
+ATATTTAAGAGATTTATAATGTGGTAGCATAAACGAATATTGTCATATTTATTTCTTGTA
+TAATTAGATAATTATTCCATGTATGAAAAAATTAGATTATAATGGGTTATATAGTATTAT
+GGATAATGATAAGCCTGTATTCTTACAATGTTTATAATGAGAAGTTCGTGGCATGAATTT
+AATGATATAAAGAGGTGGAATAATTATGCTATTTGGATTATTTAATAGTAGAAAAGATAA
+CGATGAAATTCATAATATAAAGCAGTATGCAGTAGATATAGCGACTAATTTTAATGACGA
+AGACAGGGAATATTTGAAGCCAATTTATACAATTAAGTATTATTCTAAATTAAATAATTC
+AGTTGTTAAAGAAGCAATTTTTTCTAAAAATATAGAAAATGGTGATATTACTTTAGGAGA
+AGCATTTTTAACGTTAGAGGAAATATTAAAACAGAGTATAGAGAGTAAGTTGTTAATTAA
+TACAATGATTAATAAAAATTATGTGCTTACCAATGAGGAAGAAATTACAATTAATAAACT
+TGAAGATATAATAAGATTTGGGTTGCTATAATCAATCCAAATTTAAAAAGTGTGAAGCTT
+AATATAATAGATAATGTGTGTATATTCTAAAATGGATATGGAAAGAGCAATAATTTAACT
+TATTGCTCAGATATTAATTATGCCAATACCACGAATTTGGGATTCAGGTGGACAAAAACA
+ACTTGTTCTTTGAGAATTGAACAGTATTATATTTTGAAAATATGTTGTTAGGATGAATTA
+AAATATGAATAAAGGAATGGAATAAGCTGTTATGCATATGAAGGTGAAATAGATGAATAG
+TTGTAAATTGTTAGAGGTTAAAGCTATAGTTCAAAATCCATATTATAAGGCTCCAAGTTG
+GATTGATGACAAGATCCAGAGGAGAGAATTTGTTGTTTTAGATGGGGATTCATCAGAAAA
+CGATGTGGAATTATTTTTAATTGAATTATTAGGCTATAATAATATTAACATTGAGCAGGA
+TACAGAATTAGTTATGAAAGAAGTTTTAGAGGAAGTTGAAATAGTAATAGCAGGAGGAAT
+ATTATTTGTTGGAGAAAATAGAAATATATTTCCAAGCTGTTGTTGCGGTTTGGAAAGTTG
+GAATGAAGTATTAGCTGCAGTTATTGATAAATCATCACCATGGTTAGGACACGATCCATA
+TCCCTGCTTTGAGTATGTTGGAAACAACATTCGTATATGGTCTGATGATTTTAAGACAAA
+ACAGTCAAGTGAGATTTACTTTGTTGAGTGTGATAGGGATATTTTAATCGAAAAACTAAA
+ATTAGTTAGAAATGATTTAATTAAATTCTCTAAAGGGCCTTTATATAATCATATCAGTAA
+ACATGCAAGAACATATACTGATTTGATGGTACAGCAATTTGAAAAATGGTTTTCTTTAAA
+CCTTGTGTAATATAATCTGAATGACATGTAGCTAATTGATGAACTGATATAAATCATTAT
+GGGATTTTAATATAAAATGATTTAATTTAATTTGTGGAGGAGGAGAATTTTAAGCTTGAC
+TAAAAGAAATCATAAGTTTGAAATAGCGATATTAACATAGTAGTTATTGTAAATTATTTG
+CTGAAGGTGATGAGTTGAAGAGTATTATTTTTGAAGGTTGGAAAATAGAAATTGATAAGG
+AAAAAACTAAAAATTATTATTCACAGTTATATATAGATAGTTTACGTGAATGTTGTTCAG
+ATTGTAGAAATTATTATTATGGAATAAGGCATTTGCCTAAAGTTTTTATAGATTTTTTAG
+AGAGCTTATTTATTGTTCCAGAAACACCTATATGCGCTTATAAGCTGGATAAAGTTGCTG
+ATAATATATTCCTATATGATGTAAATTATTTAATTAGGGGTAACATATTAGAAAAACCTG
+ATAATGCTGAAACTGTTTCAGAAAATGGAAAGAAGGTATTTAACACAAGTACGTTAACTG
+ATGAGGTAGAGTTTTATTTTACAAAAGAATTACATCCAAGTTTGCGAAATCTTTCTGGTT
+ATGAATCGTATTTTGAACTTCAATTATTTTGTGAAATTCCTTGGGTTATAGATGAGCCGT
+ATGAATAATTGCTGGTTGAAAATTATTGCATCGCACATCTATATAATAAAAAGTTATAAA
+TATTTAAAATAGATGAAAAACTATTAAACAATATAATTGACACTTAACAATATAAGGTAT
+ATAATTATACAAAAATAAAAGCTATGAAGAGAAGAGTAATTATGAGGGAATACTCAGAGA
+GTTTCCATTTGGTGTGAGGAAATTATGAAATCATAATGAAACAAGTCTCGGAGCTGCATA
+CGGATCTTATAAAGTAAAACTTTTCAGGTGGAATTTTATTTTCGCTAAATTTAGTTTAAC
+TTATCTTAGAGAGTGCAACCTATAACTCACATTTGAAGAAGATATGATGTTACGGATGCC
+TAGCTATAAGATAAAAATTAATTATAAGTGATGCTATGACGTAAGTTCACGTTACAGAAC
+CAGAGTATGATTCAACCTATAATTTTAGGGAGATGGTGTACTTGAAGAGCCTAAAATGGT
+GACATTTTAGGGAAAAGGGTGGCATCGCGAAATAGAAGTTTCGCCCCTGTAGATATATTT
+TCTACAGGGGCTTTTTTGACTTTAAAATTAAGCATATAAAAAATTATAAGTTTAAAATAT
+CATGGATATTTTATTTTTCGATTATCTCAAGTATGAAATTTAGAAACTTAAGGAGTGAAA
+AGTTTATGATAAGTAAAAGAATAGAAAAAAACGAAAGACCAACATTTCCAAAGAAGGCTG
+TAGTAACAGCTGGAATGCCTTATGGAAATAAGAATCTTCATTTTGGCCATGTTGGAGGAA
+TGTTCATTCATGCAGATATATTTGCAAGATTTTTAAGAGACAGAATAGGGAAAGAAAATG
+TTATTTTTGTATCTGGTACAGATTGTTATGGTTCACCTATTCTTGAAAGTTATAGAAAGC
+TAAAGGAAAATGGATACGAAAATACTATGGAGGACTATGTTAAGGCAAATCATTTGAGTC
+AAAAGAAAACCTTAGAAGATTACAATATCAGCTTAAATATTTTTGGAGCTTCAGCCATTG
+GAAGGACAGGAGAATTTCATAATGAAGTTTCAGAAGAAATATTTAATACTTTATTTAAAA
+ATGGTTATATAAAAAAGATGTCAGCACTGCAATTTTATGATGAAGATAAGAAAATCTTTC
+TTAATGGAAGGCAAGTAATAGGAAAATGTCCAATAGCCGGATGTAACTCTGATAAAGCTT
+ATGCAGAGGAATGTTCATTAGGGCATCAATATATGGCATCAGAATTAATTAATCCCATTA
+GCACTTTATCAGGAAATAAACCAATATTAAAAAGTGTAGATAATTGGTATTTTACATTAG
+ATGAATCCATGGATATAATGAAGGAACTTAATGAGTTTTTAAAGAAGAATACTAATAGAC
+GAAAGTATGAAATTAACACTATAGATGAATTTTTAAAGAAGCCATTAATATATGTTCCAA
+GAAAATATATAAAGGATGTAAATGAGCTAGAAGCTAAATTTCCAAGCCATGAAACTATAG
+ATGAAGAGAAAAAATCTTCACTAGCGTTTATTTTCCAAACACTAGAGGATAGAGATAAAG
+CAAAAGAAATATTGGATAATTTAAATATTAACTATACTAGTGGTAAGACATTGGTTCCTT
+TTAGATTGTCAGGAAATATAGAGTGGGGAGTAAAAGTACCAGATAAAGAAGATTTAAAAA
+ATTTAACATTCTGGGTGTGGCCAGAATCCTTATGGGCTCCAATTTCTTTTACAAAAGCAT
+ATTTGGAGTCAATAGATAAGAGTCCTGAAGAGTGGAGTAATTGGTGGGATGCTGATGATT
+CAATGGTATATCAATTTATAGGGGAAGATAATATATATTTTTATTCAATTGCTGAAATGG
+CCATGTTTATTGGCTTAAAGGTGGCTAAGGGTGAAAATGTAGATGTTACTAAGCTAAATT
+TGCCACACATTGTTTCTAATAAGCACATTTTATTTATGGATAAAAAAGCAAGCAGCAGTT
+CAGATATTAAGCCACCAATGGCAGATGAATTATTAAAGTTTTATACGAAGGATCAATTAC
+GCATGCACTTTATGAGTCTTGGATTATCTTCAAAAAGCGTTGGCTTTAAGCCACAAGTTT
+ACATGAAGGAAGAAGAAAAAGTAGGAGCGGATCCAGTATTAAAAGAAGGAAACCTTTTAA
+CCAATGTATTTAATAGACTCATTCGCTCATGTTTTTATACTCTACAAAGTCTTAATGAAG
+ATATTCCTAAAGAAGAGGTAAGCAAAAAAATTAAAGAATTAACAGAAAAAGCAGTATTAG
+AATATGAAAGACATATGTATAATCAAGATTTTCATAGAATAGCATATGTTCTCGACGATT
+ATATAAGGGAAGTAAATAAACATTGGGCTAGTAATATTAAAAATGAGGAATTAAAAAGAA
+ACGTAATAGCAGATTGTTTTTACGCTTGCAAAGTTATAGCAGTACTAATACACCCTATAG
+CACCAGAAGGATGTGAAATGTTTAAAGATTATCTAAATATAGATGATGAACTATGGAATT
+GGGATAAAGTATTTGAACCTATTACTTCTTATTTTGAAGATGCTGATAACCATAAGTTTA
+AATTTCTTGAACCCAAAGTAGATTTCTTTAAGAAAATGGAATATCAATATTAATGGAAAA
+ATGATATGGTTTTTACAATTTATGTTGTAATTAATCTAATTCAGATATTGTTTTATTAGA
+GTGTGTTGGAACAATATCGGATTAGATTAATTATTTGTTAGGGTGGTTTCTAGTGAAATA
+TTGTTGTACTGAGTCAAATAGAAAAGGCACATGTTATCATGAATTTCGAAAAGGAAAATT
+TACTGGCTCTTTTTGGAATGAAGATTCGCTTTTAATACATGATGATAATTTGTATAGTTT
+ACATCTAGCAGATATATTTCGTAGTGTTGTTCCTTGTATGAAAAAAAGATTATAATGGGT
+TATATAGTCTTATAGATGACAATAGGATTGTATTCTTATAATGTCTATAATAGGAAGTTG
+ATGTGAGTAGATAAAAGTACAAAGAATACTGATTAAGGTTTAGAATAATTAAGGGTGAAC
+CGTACCACAAGTAACGGAGGTTTTTTTGAAGCATAATTATAATCATACTATATAAGCAAA
+TATAAATATTTAAGAGTGTAGAGCTTCATACTAATTAAAGCCAATATGAAGCTCTATACT
+CTATAATAAATAGACTAAATCAATAAGAAAATAAATATTTTAAAATATTCCACAAAAAAA
+TTGTAACTGCAATGCAAGCTGAACATTGATAAATTGTTTGATAGAATAAATCATTACGAC
+CTTTTGCTTCTGACCAGTTAACAAATTTCCGTATTAATATAATCACGATAGGTAGAAGCA
+GTAATTGTAAAAGAAATCAACTGTAACAGAGATTATTTAAATCTTGAAAATGGAATGCTC
+AAAGGAAACTGTTAAAGTACTAAGAAAAGCAATAGAAAAATAATCAAATAAGAAGATTAT
+GAATTGAGAAATTGAAGATGTGAGAGATATGTATAAGTGACACAGCAGGATAATATATAA
+AAATAAATGGATGAAATACCAGGAGAAAGAAAAGTACCTGGTATTGTTTGTAATTCTAAT
+ATTCCTTGCAAACAACATCTTTAAAGAGCTTATGATTATTAGGAGCATCATGTTCACTGC
+ATGCTTGCTGAAGTTCGGGGATATCAGTAGTTCCAGCTTCTAAAGCAGTTTTGTAGTAAT
+TACATTTATAATTTATTAACTCCAAAGATTTCTGAAGAATTTCAATTCGTTTTTCTGCTT
+CTGCCTTTCTTTCTAAGAACATTTTATATCGTTTTTCAATACTAGAATCGCCTTCCACGT
+ACCCTTCAAAAAATGTCTTGATATCTTTAATCTGCATTCCTGTATTTTTCAAACATTCAA
+TCATATTGAGCCAGCTTATATCGTTGTCATTGAATCTTCGGATACCACGTTCTGTTCTTT
+CTAATAAAGGAAGAAGTCCTTCTTTATCATAATAGCGCAGTGTTGGTACTGAAAGGTTCA
+TGATTTTTGCCACTTCACCTATAGTATATTCCATTTGTAGGCTCCTTTCTAATTTTAGGT
+ATTGACCTAAAGTTAACTTTAGGGTGTATTATATGAATAAGCTTAATCTAAATTTATTGA
+AAAGTCAAGAAATATGGATTAAGAAAATATGAAACATAGCATAACAAATAAAATTTAGAG
+CCGATTTAAGGAGGGAATAAAACGACCAGTTCAAATGATTAGTTATGGAAATTATAAAAA
+GTTTAACAGAGAGGAAAGAGTTGTTATGATGAAACATGTAACATTTAAAAATGCTAATAT
+AGAAATGAAGGGGGATTTATACACTCCAGAAAACTTTGATGAAAGCAAGAAATATCCAGC
+AATTGTGGCTGTTCATCCAGGTGGAGCAGTAAAGGAACAAGTATCAGGTCTTTATTCGAA
+GAGAATGGCAGAAATGGGATACATTGCACTAGCGTTTGACGCATCACATCAGGGAGAAAG
+CGGTGGAGAACCTCGCTATCTTGAAAATCCTACAGAAAGAGTAGAAGATATTCGCAGTGC
+TATAGACTATCTTAGTACACTTTCTTATGTTGATATGGAAAAGGTAGGAGTACTTGGTAT
+CTGTGCAGGTGGTGGATACTCCATTAATGCTGCTTTGACAGAAAAAAGAATTAAGGCAGT
+TGCTACAATAAGTGCATTTGATATTGGTGCTGGTTTTAGAGGAGATGGTATGCCAGGTGG
+CTTAGAAGCAACATTAGAAACATTAAATAAGGTTGCAGCTATGCGTAGCGCACAGACCAA
+CGGAGAAGATTCTTTATATATCACATATGTTCCTAATACAGAAGAGGAAGCAAAAGCTAA
+TCCAATGGTGCTTATGAAAGAAGCATATGATTATTATCGTACACCTCGTGCACAACACCC
+AAATTCAACAAATAAATTACTATTTACTAGTCTTGATAAGATTATAGCATTTTCAGCATT
+CGGATTTGTGCCAACATTATTAACACAGCCTATTTTAGCAATAGTAGGAAGTGAAGCTAA
+TACAAAAGGATTTAGCGAAAATGCAATTGAATTGGCAAATAGTCCAAAAGAATTATTTGA
+AGTAAAAGGTGCGACACATATCGCAATGTATGATGTACCTGAGTATGTTAATCAAGCAGT
+TAATAAACTTGGAGAGTTTTTTGGGGAAAATCTATAATTAAGGACAGCTTTAAAAAGGAA
+GTACTTATAATATTTAATACATTGGCTATTATAAAGTTATCAGATGATAGAAAGTGTCAG
+TTCTGAAATATTTCTAAATTTAAAAGATTATGTGATTGGACAACAAGCCTTAATTACCGG
+TGAAACAGTGATTAAGGCTTTTTCTAGTGTAAAAAATATGGAAGATTACTATGCTGAGAA
+AAAATGCTTTAAGACACTAAAATATCGGAAATATCAGCAATACATTAGAAGGCAGTATTG
+TTTAAAATTAATGATTAGTTTGCATTTCTTTTATTATTTCTAAAAACTCAATCACATCCT
+TGGATGGATTTAAGGGATAGAACAAGCCATAAGGTATAGTGAAATCCAAATCGCTAGGGA
+TGGTCACTAATGAGGGATGAATATCTGACCAGGCATCTAATGTTAAGAGGATAAGGTTAT
+TTTGCCCGCAGCGATTGAATACATCAATATCATAAAGACGAGGAACACTTTTAATATGAA
+TTTCAGGATGGTTCTTTATGAAAAATTCACTGATTTCATCAATGGATGCACTAGTTCCAC
+CTTTTATTACAACCAACTTTTCTCCATACAAATCTGTTACAGAAAGTTTTTTCTTAGAAG
+CCAGCCGATGTTTGCGAGATACAGCAAAGCAAAAATGGTAAGTTCCTAGCTTAAGTTTAT
+GGGAATAATCATTCCAATTTTCTGTGAGGAATGGTCCTACTATGAAATCAAAATGTTTGC
+CAATGTTACGATAAGTGTTTGGTAATGTATATGCATCATCCTCAAAAGGGACAATTTTTA
+TCTCGAACTGGGGATGTTTATTACTGATTTCATTCCAAAGATCCAGTAAAACCTTACAGG
+GATTAAGTATAGAGGTCCCAACCCGAATAATATGCTTATCTACATGCGTTGTATTACGTG
+TACGCAGTAGTGCTTCTTGAAAATACTGCAAAATAAATTCTGCATCCTTATTGAAGGATT
+TTCCTGCATCGGTCAGTTCAACACCATGGTTGGTGCGAATGAAAAGAGGTACACCCACTT
+CCTTCTCAAGGGAATTAATCTGTTTCATCACAGCCGTTGGGGAAACAAACAGTTTTTCAG
+CAGCCTTGGAAAAGCTACCAGACTCTGCTACCTGAATAAAAGCATTCAATTGTTCATTCA
+TTTAAAGAATCTCCTTTTTGCATAAACTTTTAGTTAATGCCATGCTAACCTATTTGAACT
+TCCAAATCAAGCGATTATACATTAATATTAGAACTATACTAAAGAAACACAAGTTAAAAA
+AAGGAGATGCTTACTATGAAAACAGCATTAGTTACTGGTTCCAACAAAGGAATAGGTTTT
+GAAATTTCTAAAAAATTGTTAAAAGAAGGATATCACGTTTTAGTTGGTGCTCGAGATGAA
+AGCCGTGGCAAGAATGCAATAACAAAACTCGCTAAGTATGGTCCTGTTGATTTAATAAAA
+ATAGATTATTCAGATAGTGAAAGTATAAAAGAGGCAGTACAGCGAGTTTCAAATGAATAT
+AAAAAGCTTAATTTATTGGTTAATAATGCAGGCATACCTGGACCACTTATTAAACGCCCT
+AGCTGGGAATTTACAAAAGAAGAGCTTTTAGAAACTTATACAGTAGATTTTCTTGGTCCA
+TTTGAGCTGTCGAAAGGATTATTACCCATTCTTATAGAGAACCATGGCAAAATAGTCAAT
+GTTTCAATTCCAATTGAACCAATGCCATTTCCTAATATGAACCCTTTTGCATATCTAACT
+GGAAAAGCACCACTTAATATAATGACAAAGTCTTGGGGAATTAGCATTGATGAGATTGCT
+CTTCCGGTACAGATATTTGCAGTGATGCCCGGTGCCGTTTCAACTGATTTGAATAATCAT
+ACAACAGGAAAGGGTGTAAAAATGCCTGAAGAAGCTGCAGAATGGATTGCAGGTTTAGCT
+TTGGATGAAAAAAATCACAATGGTCAAGTTATCAATTTTGAAGGTAAGCTAGCTGACTAT
+AAAAATTTAGTATAGTTTATTTTGTCAATAAAAAAGACACTGGCAAATGGACTTGTTATT
+TGATTGTGCCTAAATATAATAAGAGAGTAAGGAAAATGGAGTATCACTTATTAATGGATA
+CGGTGAATCATAATTCCTTCTCTTATTTTCTCTTCATTAATATTTGTATAGTTCAAGCGT
+AAGGTATTTTTATGACCGCCATTTGGGAAAAATGCTTCGCCTGAAATAAAAGCTATACCA
+TTTTTTTAATGCACATTTTAATAATTCAAAGTGGTACTCCGTCTAGACATCAGATAAATA
+AATGAATTAGAAGTTTAAAATCGGGAACTGATAATGCACAATATATTAGGAGAGATGCCA
+TAACAATATTGAATAACTTTCTATGATGGCTAAGAATTTTTTGAAATAATGCACCAAAAA
+GAGTCCAGCAGGACATTGATATAAATCCTACGAATGCAAGGAATATAGCAAATAAGTATA
+ATATTATGCTCGATTTATAATAGGGGATTATAAAAATTGAAGTTGCCGTTATACCATAAA
+GTATTGTTTTGGGATTCATGAATTGCATAAGAATTCCAGATTTAAATGTGTAGATGCTGT
+AATCATTAATTGCATTTGGGTTAGAATTACTTTTGAGTATCTTGATAGCTAAATATATTA
+TGTATGCTGAACTAAATACCTCCATAGACAACTTTATGTTAGGAAGAAGTTTAAATAAAA
+ATAAGTTAAGATAACCACACAATAACATGATCACAGCCATACCAGTTGTAGCACCTAGAA
+CAAATTTGAATGTTTTTTTATATCCAAAGTTAGTACCATTTGTCATAGACATAATATTAT
+TTGGACCAGGTGTAAAAGTTGAAACAAGAACATAAGATAAAAGTGCAGATAAATTGAACA
+TAGCTGACCTCCTTAATGATTTAATTTGAAAAGATAGTAGTAATATGATATCATGCTACT
+AACAATTAGTGAAATCAATAGTTTAAATTGTAACAATCAAAATAAATGATTGATTTGGAG
+GCATATACAAATGGAATTTCGTCAATTAAATGCATTTATTACCGTAGCTAAGCTGAGTAA
+TTTTACAAAAGCAGCATTTGAACTAGGATATTCACAATCTGCTATCACTGCTCAGATACA
+ACAGTTGGAAAAAGAATTAGGTGTTAATTTGTTTGAAAGATTAGGGAAAAATATATCTTT
+GACTTCAGAAGGAGAACAGTTTCTTGTTTATGCTAAACAAATAATTAAGCTTTGTGATGA
+AGCAAAAAGTAATTTAAGTACATCAGATGTAGTAAAGGGAACTTTGACAATAGGGGCTAA
+TGAATCACTTTGCGCTGTTAGGCTTCCTCCTCTATTAAAAGAATTTCATGACCGCTATCC
+GGAAATTGAAATCCTTTTAAAAATGGAAGGTAATAATAAATGTAAAACATTGATAAGAGA
+AAATCAGATTGATGTTGCCTTTATTATTGGTCAGAAAATAAATGATTCTGATTTAATCAC
+AGAATTGGAATTTCCTGAACCTTTAGTTTTATTAGCAATTCCAGGACATCCACTTGCTTT
+CAAGAAACATGTTTATCCTGAAGATATTGCTGACTATAACATAATTGTTGCAGAAAAAGG
+CTGCGGATACCGAAATCTTTTTGAACGAAGTCTCAATGATGCTGGGGTAACTCCGAAATC
+AATAATGGAAATGGGAAGTATCCAATCAATCAAACAATTGACAATGAGCGGGCTTGGAAT
+AACCCTGCTTCCCAAGATTGCTGCTCAGGAGGAGTTGAAACGAAAGCAATTAAGAGAACT
+TCAGTGGTGGCAAGATTCCTTTTATTTGACTACGCAAATGGTATATCATAGAGATAAGTG
+GGGTTCAAGGGCATTAAGAGCTTTTATAAATTTGAGTAAAGAAATGATGAATAGTTAATA
+TAATATTTTGAATTCAAATAACAAAGGTATGTATTTTGTGTTCTTAGTGTTTTCTTATTT
+AATTAAACATTAACATTTTTATATGACGTAACAGTTAAAAATGGAATGATAAGAAGCATC
+TAAATAAGAATTCTTTATTTTTCAACGAAAGAACTTTTTATATAGATGATAAAGGAAAAA
+GAGTTATCACTTGCTATTGATACGGTGAACCATGTCATAAGTGAGTGATAAATTTATTAA
+GGCCAAATAATGAAAATGAATTAGAATAAAGGAACTTACCATATAAGAAAGTAATATGGT
+AAGTTTTATTTAATTTATAGACAATATAGAGACAAACAGAATAGAAAATTCATTGCAAAG
+AGCCTATAAAAAATGAAAAGAACACTATTTGATATAATGTTCTTTTCATCTTTTTAAAGT
+ACCCATACCTGTAGAAACAAACCCAATAATCTCAGAAATTAGAACTTCTTGAGGGAGTGG
+TCTATTCTGAACTTCCCATTTGTAAGTTACATTATAAATGGAAGTGCTCATCATTGTTGC
+AACTAATTGGGCTCGTATTTGTTCATTTTCAGCTAATTCATGGTCTTTTATTAGCATCTC
+ATAGATTATGGAATATAGCTCACAAGATATTTTATCTCCTATTAAAGGTAAAATAGAGGC
+AAAACCGCACTTGCAGATGCTTTTTACCATTTCAAAGTACTCACAAACGCAAAGAATGAG
+GCTACGTATAGTATTCTCATTTAGGCGCATCTCGCCTAGTAGTTTATGGGAAAAGATCTC
+AGAGAATTTCTCTACTATGACGGTGTCCAGTAGTGCATATTTATCTGTAAAATGTGCATA
+GAAGGTTGCACGGTTTATGGTGGCTGCGGTAGTAATATCCTTAACTGTAATGGAGTCAAA
+GCCTTTTTTAGTAACTAGTGAAATAAAAGCGTTGATAATAAGATCATGGGTTCTTTTTAC
+TCTAGGATTATTTATATTTACTGACATATCATTACCTCATTTAAAAGAATTTTAGTTAAA
+CTCATATTGCAGATTTAGTTTTATGTAAGCAACACTTTATCAATTTTGTTGGTTGAAAAA
+TGTATAAGCTAATTTTATAATCATTATAAGCAACACGAGTTGGCTTTGCAATATGTGTAG
+CTATAATAATTGTTTGAAATAAATATTTATTTCTAGGGGGTTAAATATGTCAACTATAAA
+TCCAAACTGTAAATGCATAAATAAAAGCTGTAAAAATCACGGGAATTGTAAAGCATGTCG
+AGAGTTTCATAAATCACAATCATATCTTAATGAAACATATTGTCAGGCTGGTGCAGTTAA
+ATTCATAACTAAAGGATTAATATCTAAGTTAAAGTTACATTCTTAGCACGCAACCTAGCA
+ATTCAAATGCGGACTTACTATAAAATAAAAAGGGTGGGAGTGCTGAAATATGAATTTAGA
+TAATCCGATTTTCAAGAAGCCAATTACAGAAGTTATTAAAGCAAGAACATCTATGAGGTC
+ATATAATGGGGTGCCTTTGGACAAAACAATAGGCGATAGCATAATGGATGTCATAAATCA
+GGTTAAAGCACCTTTTTGCACAAATATACGAGTTAAGATGATAAACTCTAAAGATTCAGA
+TTTAAAGCTTGGAACCTATGGTATTATAAAAGGAACTTCTACCTTTATAGTCTCATCAAT
+TTCAAAATCAGATAATGCATTAGTTGATTTAGGATATTTATTGGAAAGAGCAGTGCTGTA
+TGCAACTGATTTAAATTTGGGTACATGTTGGCTAGGCGGTACCTTTAATAAAGGTCAATT
+TGCAGAGGTTATGGAGCTTAAAGATAATGAAATCCTTCCAATAGTTATACCTGTAGGGTA
+TCCTAGTGAAGCAAGAAGAGGTATGGATACTTTCGTTAGGTTTATGGCAGGTTCTAAAAA
+TAGAAAAGCCTGGTCTAAACTATTCTTTGATGTAGATTTCAATACACCTTTAAAGGAGCT
+GGAAAGCTTAGAGTATTTTATTCCCCTTCAAATGGTAAGGCTTGCGCCTTCAGCAGCAAA
+CAAGCAACCTTGGAGAATAATTAAAAGTTCTAATTCATACGATTTCTATTTAGAACGAAG
+TAAAGACTCAAAAAGTGATAGTTATAATGATATGCACAAGATAGATATTGGCATAGCTAT
+GTGTCATTTTGAGTTAACTTCAGCAGAATTAGGGTTAGAGGGACATAGGGAGAAACTTAA
+GCTTTCATCTCAAGATAATAAAAAATATATTATTTCTTGGGTTAGAAAATAGGGAAGCGA
+ATTTGCTATAAATGAAATATATGTTGAATATGTAAGAGATATTGATTACTATAGCAAGTT
+ATTTTCACATTTTTCTTCATGAACTTTTTTTCTTTCTTCGTTAATAATTTGCGCCGCGTT
+AGGAGATGTATACTTCACTATTTTGGTATGAATAAGGTCTAAATTTTCATTGAGATCATT
+TTAAAGGAGTTTTCTTTTTGACACAGAAACTAATTCCGCTTATTGCTGACAAAGGTGGGA
+TTGTGAACACTTCAACAGGATTAACTCGTTTTACATCTCCAGGTTCCAGACTTTATGCTG
+CTGCGAAAGGTTCAGTAGAAGTCTTCACTAGATATTTAGCAAAAGAATTAGGAACTAGAG
+GTATAAGAGCGAATACGATAGCGCCTGGAGCTAGTAAAGGTGCCCCTTATTTTAGAAATC
+GCTTCATTGATTTAGTTACTTATAAATTAGAGGATGAAGTAAATGTTACAGAAGGAGTAA
+ATTCAGGATTAAGGAAAGATGCTGGCAAGCAATTTCTTGGGCAAGCTATAGTAGGATTGA
+TAGAATGGTGGTTTATAAATGGAATGCCTTTTTCTCCTGATGTCTTGGTGGAACATTTAG
+GAGAAGTGATAGAGAGAAATTTGTAATCATTAATTTAGACTGATTCAAATCCATTTAATT
+ATAGATAGGAAATATTAAAGGAGGTTTAGAATAATTAATAGTGAACCATATCACAAATAA
+AGGATAATGAGTAAGTTTGGGTAAAATTAGGGATAAGAAATAAATTTAATCCTAGTAAAG
+CTTATTGTTGCATTACTAGGATATTTTAATACGTTCAATATTATAAAAATAGGTGCCAAA
+ATTTTGACTCTTACGTTTAAATTGAAAAATTGTAATTGCTAGACTAAAGTATATTAAGGT
+TAAAAAAATATAATTAGTGAGGTGAAATCAAATGTATATTATACTGATTGCAGGAATGCC
+AGCAGTTGGTAAGACAACATTTGCTAACAAGGCATAGAGGTCACAGAATATCCTGAATCA
+ATAAATCACAATGCTATTCCTGATCAAATAAAATGGGTTTCAGTGCAAATCACAAGCACT
+GAAACCCATTTTAATTTGAAGCTTAACGTATATATTAAAATATCATTACTAATATTTTAG
+GTAACAGCATGGAAACACCTACTGCATAAAGTAAATCAAGCCACATTACAGAACCAACCG
+CGCCAATATAAATAAGACCAATGACAGGCGCTACTAATATTTTTATTAAAAATGATACTT
+CTTTATTCTTTAAAATAGCATTTACAATACATTTTGCATCACCTGTACTTGGGAAGGCAT
+GCATTAAAATAGAAAATCCAATCCAACAAATTAATAGATTAATTAAGTTTGAATATTGTC
+CAAATTCTACTATTTCAATTGATACTGGTAATGTAATTAGAGCTCCTATGATAGTATTTA
+TTAAAAATGGACCTACTGAAATAAAAAATACTTTTAATGGATTATCACTAGGTTCGTGCA
+AAACATATCCACAAGGATTTGATAATTGGAAATATTTAACTTCATAGACTGGCACTCTCA
+TTAGTCTGCAAAATATCTGATGTGCTAGTTCATGAACAATTACTCCAGGAAAGGTTACAA
+TAGAAATTAAAAAACCAGGTATTATCATTAATTTTGCCCTCCATTACTTAGGTAATAATC
+ATTTATATTTATTTTTCCATTAAAATAATCTAATGTAGTATTATCAAATTTGTTTCCTGT
+AGAAAGATATTCATCTTTGATTTTATTAACTTCTTCAGTT
diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/sim1_galaxy.fasta.stats
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/sim1_galaxy.fasta.stats	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,19 @@
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diff -r 000000000000 -r 68a3648c7d91 fosm_cluster/test
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/fosm_cluster/test	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,20 @@
+"x"
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+"NODE_11_length_39995_cov_63.1687_ID_21" 3
+"NODE_13_length_39994_cov_62.9723_ID_25" 9
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/aaa.fplot
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/aaa.fplot	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,9 @@
+#-- forward hits sorted by %sim
+0 0 0
+0 0 0
+
+
+1 1 100
+2100 2100 100
+
+
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/aaa.gp
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/aaa.gp	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,21 @@
+set terminal png tiny size 800,800
+set output "aaa.png"
+set size 1,1
+set grid
+unset key
+set border 15
+set tics scale 0
+set xlabel "Assembly"
+set ylabel "Assembly_22"
+set format "%.0f"
+set mouse format "%.0f"
+set mouse mouseformat "[%.0f, %.0f]"
+set mouse clipboardformat "[%.0f, %.0f]"
+set xrange [1:2100]
+set yrange [1:2100]
+set style line 1  lt 1 lw 3 pt 6 ps 1
+set style line 2  lt 3 lw 3 pt 6 ps 1
+set style line 3  lt 2 lw 3 pt 6 ps 1
+plot \
+ "aaa.fplot" title "FWD" w lp ls 1, \
+ "aaa.rplot" title "REV" w lp ls 2
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/aaa.png
Binary file mytrimmer/aaa.png has changed
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/aaa.rplot
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/aaa.rplot	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,5 @@
+#-- reverse hits sorted by %sim
+0 0 0
+0 0 0
+
+
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/f1
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/f1	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,31 @@
+>Assembly
+AGAATTCGTCTTGCTCTATTCACCCTTACTTTTCTTCTTGCCCGTTCTCTTTCTTAGTATGAATCCAGTA
+TGCCTGCCTGTAATTGTTGCGCCCTACCTCTTTTGGCTGGCGGCTATTGCCGCCTCGTGTTTCACGGCCT
+CAGTTAGTACCGTTGTGACCGCCACCGGCTTGGCCCTCTCACTTCTACTCTTGGCAGCAGTGGCCAGCTC
+ATATGCCGCTGCACAAAGGAAACTGCTGACACCGGTGACAGTGCTTACTGCGGTTGTCACTTGTGAGTAC
+ACACGCACCATTTACAATGCATGATGTTCGTGAGATTGATCTGTCTCTAACAGTTCACTTCCTCTGCTTT
+TCTCCTCAGTCTTTGCAATTTGCCTAACATGGAGGATTGAGGACCCACCTTTTAATTCTCTTCTGTTTGC
+ATTGCTGGCCGCAGCTGGCGGACTACAAGGCATTTACGGTTAGTGTGCCTCTGTTATGAAATGCAGGTTT
+GACTTCATATGTATGCCTTGGCATGACGTCAACTTTACTTTTATTTCAGTTCTGGTGATGCTTGTGCTCC
+TGATACTAGCGTACAGAAGGAGATGGCGCCGTTTGACTGTTTGTGGCGGCATCATGTTTTTGGCATGTGT
+ACTTGTCCTCATCGTCGACGCTGTTTTGCAGCTGAGTCCCCTCCTTGGAGCTGTAACTGTGGTTTCCATG
+ACGCTGCTGCTACTGGCTTTCGTCCTCTGGCTCTCTTCGCCAGGGGGCCTAGGTACTCTTGGTGCAGCCC
+TTTTAACATTGGCAGCAGGTAAGCCACACGTGTGACATTGCTTGCCTTTTTGCCACATGTTTTCTGGACA
+CAGGACTAACCATGCCATCTCTGATTATAGCTCTGGCACTGCTAGCGTCACTGATTTTGGGCACACTTAA
+CTTGACTACAATGTTCCTTCTCATGCTCCTATGGACACTTGGTAAGTTTTCCCTTCCTTTAACTCATTAC
+TTGTTCTTTTGTAATCGCAGCTCTAACTTGGCATCTCTTTTACAGTGGTTCTCCTGATTTGCTCTTCGTG
+CTCTTCATGTCCACTGAGCAAGATCCTTCTGGCACGACTGTTCCTATATGCTCTCGCACTCTTGTTGCTA
+GCCTCCGCGCTAATCGCTGGTGGCAGTATTTTGCAAACAAACTTCAAGAGTTTAAGCAGCACTGAATTTA
+TACCCAGTGAGTATCTATTTGTTACTCCTGTTTAGTTGAAGAAAACAAGCTATTGGATTGTAACACACAT
+TTTACGCTTTGTTCCTTAGATTTGTTCTGCATGTTATTACTGATTGTCGCTGGCATACTCTTCATTCTTG
+CTATCCTGACCGAATGGGGCAGTGGAAATAGAACATACGGTCCAGTTTTTATGTGCCTCGGTGGCCTGCT
+CACCATGGTAGCCGGCGCTGTGTGGCTGACGGTGATGTCTAACACGCTTTTGTCTGCCTGGATTCTTACA
+GCAGGATTCCTGATTTTCCTCATTGGTAAGTGTGACACCAACAGGTGTTGCCTTGTTATGTCACCGTTCT
+GACACATGACTTACATGGGTTTGGCTTTTGTAGGCTTTGCCCTCTTTGGGGTCATTAGATGCTGCCGCTA
+CTGCTGCTACTACTGCCTTACACTGGAAAGTGAGGAGCGCCCACCGACCCCATATCGCAACACTGTATAA
+AGGTAAGTATTATTAAATTTTAGAGACACTATCACGTGTAACTTGACGTGCAAGGATGGAAGAGAGGGGC
+AGGGAAACGCAAATGCCGGTTGCCCGGTATGGGGGCCCGTTTATTATGGTAAGGCTCTTCGGGCAAGATG
+GAGAGGCAAACATACAGGAGGAAAGGCTATATGAGCTACTCTCTGACCCACGCTCCGCGCTCGGCCTAGA
+CCCGGGGCCCCTGATTGCTGAGAACCTGCTGCTAGTGGCGCTGCGTGGCACCAACAACGATCCCAGGCCT
+CAGCGTCAGGAGAGGGCCAGAGAACTGGCCCTCGTTGGCATTCTACTAGGAAACGGCGAGCAGGGTGAAC
+ACTTGGGCACGGAGAGTGCCCTGGAGGCCTCAGGCAACAACTATGTGTATGCCTACGGACCAGACTGGAT
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/f2
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/f2	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,31 @@
+>Assembly_22
+AGAATTCGTCTTGCTCTATTCACCCTTACTTTTCTTCTTGCCCGTTCTCTTTCTTAGTATGAATCCAGTA
+TGCCTGCCTGTAATTGTTGCGCCCTACCTCTTTTGGCTGGCGGCTATTGCCGCCTCGTGTTTCACGGCCT
+CAGTTAGTACCGTTGTGACCGCCACCGGCTTGGCCCTCTCACTTCTACTCTTGGCAGCAGTGGCCAGCTC
+ATATGCCGCTGCACAAAGGAAACTGCTGACACCGGTGACAGTGCTTACTGCGGTTGTCACTTGTGAGTAC
+ACACGCACCATTTACAATGCATGATGTTCGTGAGATTGATCTGTCTCTAACAGTTCACTTCCTCTGCTTT
+TCTCCTCAGTCTTTGCAATTTGCCTAACATGGAGGATTGAGGACCCACCTTTTAATTCTCTTCTGTTTGC
+ATTGCTGGCCGCAGCTGGCGGACTACAAGGCATTTACGGTTAGTGTGCCTCTGTTATGAAATGCAGGTTT
+GACTTCATATGTATGCCTTGGCATGACGTCAACTTTACTTTTATTTCAGTTCTGGTGATGCTTGTGCTCC
+TGATACTAGCGTACAGAAGGAGATGGCGCCGTTTGACTGTTTGTGGCGGCATCATGTTTTTGGCATGTGT
+ACTTGTCCTCATCGTCGACGCTGTTTTGCAGCTGAGTCCCCTCCTTGGAGCTGTAACTGTGGTTTCCATG
+ACGCTGCTGCTACTGGCTTTCGTCCTCTGGCTCTCTTCGCCAGGGGGCCTAGGTACTCTTGGTGCAGCCC
+TTTTAACATTGGCAGCAGGTAAGCCACACGTGTGACATTGCTTGCCTTTTTGCCACATGTTTTCTGGACA
+CAGGACTAACCATGCCATCTCTGATTATAGCTCTGGCACTGCTAGCGTCACTGATTTTGGGCACACTTAA
+CTTGACTACAATGTTCCTTCTCATGCTCCTATGGACACTTGGTAAGTTTTCCCTTCCTTTAACTCATTAC
+TTGTTCTTTTGTAATCGCAGCTCTAACTTGGCATCTCTTTTACAGTGGTTCTCCTGATTTGCTCTTCGTG
+CTCTTCATGTCCACTGAGCAAGATCCTTCTGGCACGACTGTTCCTATATGCTCTCGCACTCTTGTTGCTA
+GCCTCCGCGCTAATCGCTGGTGGCAGTATTTTGCAAACAAACTTCAAGAGTTTAAGCAGCACTGAATTTA
+TACCCAGTGAGTATCTATTTGTTACTCCTGTTTAGTTGAAGAAAACAAGCTATTGGATTGTAACACACAT
+TTTACGCTTTGTTCCTTAGATTTGTTCTGCATGTTATTACTGATTGTCGCTGGCATACTCTTCATTCTTG
+CTATCCTGACCGAATGGGGCAGTGGAAATAGAACATACGGTCCAGTTTTTATGTGCCTCGGTGGCCTGCT
+CACCATGGTAGCCGGCGCTGTGTGGCTGACGGTGATGTCTAACACGCTTTTGTCTGCCTGGATTCTTACA
+GCAGGATTCCTGATTTTCCTCATTGGTAAGTGTGACACCAACAGGTGTTGCCTTGTTATGTCACCGTTCT
+GACACATGACTTACATGGGTTTGGCTTTTGTAGGCTTTGCCCTCTTTGGGGTCATTAGATGCTGCCGCTA
+CTGCTGCTACTACTGCCTTACACTGGAAAGTGAGGAGCGCCCACCGACCCCATATCGCAACACTGTATAA
+AGGTAAGTATTATTAAATTTTAGAGACACTATCACGTGTAACTTGACGTGCAAGGATGGAAGAGAGGGGC
+AGGGAAACGCAAATGCCGGTTGCCCGGTATGGGGGCCCGTTTATTATGGTAAGGCTCTTCGGGCAAGATG
+GAGAGGCAAACATACAGGAGGAAAGGCTATATGAGCTACTCTCTGACCCACGCTCCGCGCTCGGCCTAGA
+CCCGGGGCCCCTGATTGCTGAGAACCTGCTGCTAGTGGCGCTGCGTGGCACCAACAACGATCCCAGGCCT
+CAGCGTCAGGAGAGGGCCAGAGAACTGGCCCTCGTTGGCATTCTACTAGGAAACGGCGAGCAGGGTGAAC
+ACTTGGGCACGGAGAGTGCCCTGGAGGCCTCAGGCAACAACTATGTGTATGCCTACGGACCAGACTGGAT
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/out.fplot
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/out.fplot	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,9 @@
+#-- forward hits sorted by %sim
+0 0 0
+0 0 0
+
+
+1 1 100
+2100 2100 100
+
+
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/out.gp
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/out.gp	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,21 @@
+set terminal png tiny size 800,800
+set output "out.png"
+set size 1,1
+set grid
+unset key
+set border 15
+set tics scale 0
+set xlabel "Assembly"
+set ylabel "Assembly_22"
+set format "%.0f"
+set mouse format "%.0f"
+set mouse mouseformat "[%.0f, %.0f]"
+set mouse clipboardformat "[%.0f, %.0f]"
+set xrange [1:2100]
+set yrange [1:2100]
+set style line 1  lt 1 lw 3 pt 6 ps 1
+set style line 2  lt 3 lw 3 pt 6 ps 1
+set style line 3  lt 2 lw 3 pt 6 ps 1
+plot \
+ "out.fplot" title "FWD" w lp ls 1, \
+ "out.rplot" title "REV" w lp ls 2
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/out.png
Binary file mytrimmer/out.png has changed
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/out.rplot
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/out.rplot	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,5 @@
+#-- reverse hits sorted by %sim
+0 0 0
+0 0 0
+
+
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/test.delta
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/test.delta	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,5 @@
+/home/inmare/galaxy/tools/mytrimmer/f1 /home/inmare/galaxy/tools/mytrimmer/f2
+NUCMER
+>Assembly Assembly_22 2100 2100
+1 2100 1 2100 0 0 0
+0
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/trim.seqs.C.cpp
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/trim.seqs.C.cpp	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,208 @@
+#include <iostream>
+#include <fstream>
+#include <algorithm>
+#include <vector>
+#include <map>
+#include <math.h>
+#include <string>
+
+using namespace std;
+int main (int argc, char *argv[]);
+int eval_quality(string & qstring,int lencutoff,int errors);
+
+int main (int argc, char *argv[])
+{
+	if (argc==9)
+	{
+		unsigned long inseq=0;
+		unsigned long outseq=0;
+		unsigned long pfile=0; 
+		ifstream infile;
+		ifstream infileP;
+		string file=argv[1];
+		string filep=argv[2];
+		ofstream outfile;
+		ofstream outfilep;
+		ofstream outfileunm;
+		string outname=(argv[6]);
+		string outnamep=(argv[7]);
+		string outunm=(argv[8]);
+		outfile.open(outname.c_str());
+		outfilep.open(outnamep.c_str());
+		outfileunm.open(outunm.c_str());
+		int cutoff=atoi(argv[3]);
+		int errors=atoi(argv[4]);
+		int discard=atoi(argv[5]);
+		infile.open(file.c_str());
+		infileP.open(filep.c_str());
+		if (!infile)
+		{
+			cerr << "Couldn't open "<< infile << "\n"; 
+			exit(1);
+		}
+		if (!infileP)
+		{
+			cerr << "Couldn't open "<< outfile << "\n"; 
+			exit(1);
+		}
+		map <int,int> Min;
+		map <int,int> Max;
+		if (infile.is_open() && infileP.is_open()){
+			string header;
+			string seq;
+			string seqp;
+			string qscore;
+			string qscorep;
+			while (!infile.eof() && !infileP.eof())
+			{
+				getline(infile,header);
+				if (header!="")
+				{
+				//read headers + sequences
+				getline(infile,seq); //
+				getline(infileP,seqp);
+				getline(infileP,seqp);//
+				//
+				//cout <<"A:" << seq << "\n" << "B:" << seqp << "\n";
+				inseq+=seq.length();
+				inseq+=seqp.length();
+
+
+				//read Qscores
+				getline(infile,qscore);
+				getline(infile,qscore);//
+				getline(infileP,qscorep);
+				getline(infileP,qscorep);//
+				if (discard >0 && discard<=seq.length())
+				{
+					seq=seq.substr(discard-1,seq.length()-discard);
+					seqp=seqp.substr(discard-1,seqp.length()-discard);
+					qscore=qscore.substr(discard-1,qscore.length()-discard);
+					qscorep=qscorep.substr(discard-1,qscorep.length()-discard);
+				}
+				if (qscore.length()!=seq.length())
+				{
+					cerr << "Invalid fastq\n" << seq << "\n" << qscore  << "\n";
+					exit(1);
+				}
+				
+				if (qscorep.length()!=seqp.length())
+                                {
+                                        cerr << "Invalid fastq\n" << seqp << "\n" << qscorep  << "\n";
+					exit(1);
+                                }
+
+	
+				//
+				//cout << qscore << "\n" << qscorep << "\n";	
+
+				//eval Qscores
+				int p=eval_quality(qscore,cutoff,errors);
+				int pp=eval_quality(qscorep,cutoff,errors);
+	
+				string Qheader=header;
+                                if (*(Qheader.end()-2)=='/') // togli gli slash
+                                {
+                                	Qheader.replace(Qheader.end()-2,Qheader.end(),"");
+                                }
+                     		string Oheader=Qheader;
+                     		Oheader[0]='+';                   
+				if (p>0)
+				{
+					seq=seq.substr(0,p);
+					qscore=qscore.substr(0,p);
+					if (pp>0)
+					{
+						seqp=seqp.substr(0,pp);
+						qscorep=qscorep.substr(0,pp);
+						outseq+=seqp.length();
+						outseq+=seq.length();
+						outfile << Qheader <<"/1" << "\n" << seq << "\n" << Oheader <<"/1" << "\n" << qscore << "\n";
+						outfilep << Qheader <<"/2" << "\n" << seqp << "\n" << Oheader<<"/2"  << "\n" << qscorep << "\n";
+					}else{
+						outseq+=seq.length();
+						outfileunm << Qheader <<"/1"  << "\n" << seq << "\n" << Oheader<<"/1"  << "\n" << qscore << "\n";
+					}
+				}else if(p==0 && pp>0){
+					seqp=seqp.substr(0,pp);
+					qscorep=qscorep.substr(0,pp);
+					outseq+=seqp.length();
+					outfileunm << Qheader <<"/2"  << "\n" << seqp << "\n" << Oheader <<"/2"  << "\n" << qscorep << "\n";
+				}	
+				}
+			}
+			
+		}else{
+			cerr << "could not open files\n";
+		}
+		//cerr << "Input "<< inseq << " bases.\nOutput " << outseq << " bases.\n";
+	}else{
+
+		cout << "input: <first_file> <second_file> <len_cutoff> <number of errors> <low qual base> <ofile1 <ofile2> <ofile3>\n";
+	}
+}
+
+int eval_quality(string & qstring,int lencutoff,int errors)
+{
+	int Nminori10=0;
+	int Nminori20=0;
+	int Nmaggiori25=0;
+	int l10=0;
+	int l20=0;
+	int p=0;
+	double total_perr=0;
+	string::iterator pos;
+	for (pos=qstring.begin();pos!=qstring.end();pos++)
+	{
+		int punteggio=static_cast<int> (*pos)-33;
+		if (punteggio>=1 && punteggio <=41)
+		{
+			double exp=(double)punteggio/-10;
+			total_perr+=pow(10,exp);
+			if (p>0)
+                	{
+                		if (punteggio<=10) //count qscores <=10
+                        	{
+                         		l10++;
+                                	Nminori20++;
+                                	Nminori10++;
+                        	}else if (punteggio<=20){ // count Qscores <=20
+                        		l20++;
+                        		Nminori10=0;
+                        		Nminori20++;
+                        	}else if (punteggio>20){
+                        		Nminori20=0;
+                        		Nminori10=0;
+					if (punteggio>=25)
+					{
+						Nmaggiori25++;
+					}
+                        	}
+			}
+			if (Nminori10>=10) // 3 or more consecutives very low quality bases
+                	{
+                		p-=Nminori10;
+                       		break;
+                	}else if (Nminori20>=15){ // 5 or more consecutives low quality bases 
+                		p-=Nminori20;
+                        	break;
+			}
+                	if (total_perr>=(double)errors) // sum of per base error probability when 5e-2 5 wrong base calls in 100 
+                	{
+				//cout << p << " " << total_perr << " " << errors << "\n";
+                		break;
+                	}
+			p++;
+		}else{
+			cerr << "Invalid Qscore" << *pos << "=" << punteggio << "\n";
+			exit(1);
+		}
+	}
+	double prop_gr_25=(double)Nmaggiori25/(double)(p);
+        if (prop_gr_25>=0.35 && p>=lencutoff && l20 <= p*0.2 && l10 <= p*0.1) // if 50% of Qscores are >= 25,size is >= cutoff a 
+	{
+		return p;
+	}else{
+		return 0;
+	}
+}
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/trimPE
Binary file mytrimmer/trimPE has changed
diff -r 000000000000 -r 68a3648c7d91 mytrimmer/trimPE.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/mytrimmer/trimPE.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,27 @@
+<tool id="trimmer" name="Custom quality trimmer" version="0.">
+ <description>trimming tool for Illumina PE data</description>
+ <command> /home/inmare/galaxy/tools/mytrimmer/trimPE $f1 $f2 $l $ne $disc  $o1 $o2 $o3</command>
+ <description> "approved by the boss" </description>
+ <inputs>
+ 	<param name="f1" type="data" format="fastq" label="R1 reads file" help="fastq only"/>
+ 	<param name="f2" type="data" format="fastq" label="R2 reads file" help="fastq only"/>
+ 	<param name="l" type="integer" label="minimum read length" value="100"  help="don't go too short!"/>
+ 	<param name="ne" type="integer" label="max number of errors" value="10"  help="usually between 2 and 10"/>
+ 	<param name="disc" type="integer" label="cut xx bp from the beginning of each read" value="15"  help="have a look to the fastqc report"/>
+ </inputs>
+ <outputs>
+ 	<data name="o1" ftype="fastq" format="fastq" label="r1 trimmed reads"/>
+ 	<data name="o2" ftype="fastq" format="fastq" label="r2 trimmed reads"/>
+ 	<data name="o3" ftype="fastq" format="fastq" label="unmated reads"/>
+ </outputs>
+ <test/>
+ <help>
+	Our custom script for quality trimming implements strict quality filters based on the provided base call quality scores. Reads are iteratively trimmed from the 3' end until all of the following conditions were satisfied:
+1. the median quality score (Qscore) of upstream bases is ≥15
+2. less than 10 bases with Qscore ≤10 and less than 15 bases with Qscore ≤ 20 are present in the upstream sequence
+3. the cumulative error probability in the upstream region is below a user defined cutoff
+4. the length of the trimmed read exceeds a user defined cutoff
+
+The program is designed to work with paired end sequencing files only, the output consists in 3 distinct files containing the pairs where both mate passed the filters (output to 2 separate files) and a third file containing all the singleton reads, for which the corresponding mate did not pass the quality filters.
+ </help>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/Active_site/as_search.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/Active_site/as_search.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,399 @@
+package Bio::Pfam::Active_site::as_search;
+
+use strict;
+use warnings;
+
+use Bio::SeqFeature::Generic;
+use Bio::SimpleAlign;
+use Bio::Pfam::Scan::Seq;
+
+=head2 find_as
+
+ Title   : find_as
+ Usage   : find_as($as_aln, $as_res, $seq_id, $seq_se, $seq_region, $family, $hmm_file)
+ Function: finds active sites in a query sequence which 
+           has a match to a Pfam active site family
+
+ Returns : An array reference of active site postions
+ Args    : Alignment object of active site sequences, hash of arrays containing seq ids => active site positions, 
+           start-end sequence in the format "3-50", sequence region, family,  file containing all Pfam models
+
+=cut
+
+sub find_as {
+  my ($as_aln, $as_res, $seq_id, $seq_se, $seq_region, $family, $hmm_file) = @_;
+
+
+  system("hmmfetch $hmm_file $family > /tmp/hmm.$$") and die "FATAL: Problem running [hmmfetch $hmm_file $family > /tmp/hmm.$$]\n";
+
+  $seq_id = "Query_".$seq_id; 
+
+  my $fasta;
+  foreach my $seq ($as_aln->each_seq) {
+      my $s = $seq->seq;
+      $s =~ s/[\-\.]//g; #Remove gaps
+
+      $fasta .= ">" . $seq->id . "/" . $seq->start . "-" . $seq->end . "\n$s\n";
+  }
+  $fasta .= ">$seq_id/$seq_se\n$seq_region";
+  open(SEQ, ">/tmp/seqs.$$") or die "Couldn't open file seqs.$$ $!\n";
+  print SEQ $fasta;
+  close SEQ;
+ 
+
+  open(OUT, "hmmalign --outformat Pfam /tmp/hmm.$$ /tmp/seqs.$$ |") or die "Couldn't open fh to hmmalign $!\n";
+
+  my $aln = new Bio::SimpleAlign;
+  my ($name, $start, $end, $seq);
+  while(<OUT>) {
+    if( /^(\S+)\/(\d+)-(\d+)\s+(\S+)\s*/ ) {
+	$name = $1;
+	$start = $2;
+	$end = $3;
+	$seq = $4;
+	    
+	$aln->add_seq(Bio::Pfam::Scan::Seq->new('-seq'=>$seq, '-id'=>$name, '-start'=>$start, '-end'=>$end, '-type'=>'aligned'));
+    }
+  }
+  close OUT;
+  
+
+  unlink "/tmp/seqs.$$";
+  unlink "/tmp/hmm.$$";
+  
+  #Locate exp as in fam
+  _exp_as($aln, $as_res);
+
+  #Store as patterns
+  my $pattern_aln = new Bio::SimpleAlign;
+  _pattern_info($aln, $pattern_aln);
+  #find pred as
+  my $array_ref = _add_pred_as($aln, $pattern_aln, $seq_id);
+  return $array_ref;
+}
+
+=head2 _exp_as
+
+ Title    : _exp_as
+ Usage    : _exp_as($aln,  $hash_of_arrays)
+ Function : Adds experimental active site data to alignment object
+ Returns  : Nothing, populates the alignment object with active site residue info
+ Args     : alignment object
+
+=cut
+
+sub _exp_as {
+ 
+  my ($aln, $as_res) = @_;
+
+
+  foreach my $seq ($aln->each_seq) {
+
+      foreach my $pos ( @{$as_res->{$seq->id}}) {
+
+        if($pos >= $seq->start and $pos <= $seq->end) { #Feature is in the alignment
+                  
+             #store column position for seq
+             my $col = $aln->column_from_residue_number($seq->id, $pos);              
+
+             #add feature to seq
+             my $aa .= uc substr($seq->seq(), $col-1, 1); 
+
+             my $feat = new Bio::SeqFeature::Generic  (  -display_name => 'experimental',
+                                                         -primary => $aa,
+							 -start => $col);
+
+
+
+	     $seq->add_SeqFeature($feat);
+	 }
+
+    }
+  }
+}
+
+
+=head2 _pattern_info
+
+ Title    : _pattern_info
+ Usage    : _pattern_info($aln_object, $aln_object)
+ Function : Takes an alignment and extracts active site patterns into a second alignment
+ Returns  : Nothing, populates a second alignment object with active site seqences
+ Args     : alignment object, empty alignment object
+
+=cut
+
+
+sub _pattern_info {
+    my ($aln, $pattern_aln) = @_;
+    my (%pat_col_seq);
+  
+    foreach my $seq ( $aln->each_seq() ) {  
+
+	next unless($seq->all_SeqFeatures());
+           my ($pat, $col);
+           foreach my $feat ( sort {$a->start <=> $b->start }  $seq->all_SeqFeatures() ) {            
+              $pat .= $feat->primary_tag();   #HEK
+              $col .= $feat->start() . " ";    #33 44 55
+	   }
+
+           unless(exists($pat_col_seq{"$pat:$col"})) {
+	       $pattern_aln->add_seq($seq);
+               $pat_col_seq{"$pat:$col"}=1;
+	   }
+
+    }
+}
+
+
+
+=head2 _add_pred_as
+
+ Title    : _add_pred_as
+ Usage    : _add_pred_as($aln_object, $aln_object)
+ Function : Predicts active sites based on known active site data
+ Returns  : array of active site pos
+ Args     : alignment, alignment of known active sites
+
+=cut
+
+
+
+
+sub _add_pred_as {
+    my ($aln, $pattern_aln, $query_seq_id) = @_;
+    my $num_seq=0;
+    my ($query_seq, @as_res);
+
+    #locate query seq
+    foreach my $seq ( $aln->each_seq() ) {  
+	    if($seq->id eq $query_seq_id) {
+		$query_seq = $seq;
+		last;
+	    }
+    }
+    die "FATAL: Can't locate query sequence [$query_seq_id] in active site alignement\n" unless($query_seq);
+
+
+    my   $aligns_with = new Bio::SimpleAlign;
+    foreach my $seq1 ( $pattern_aln->each_seq() ) {
+
+   
+           #See if all active site residues from seq1 exist in query seq
+           my $mismatch;
+           foreach my $feat ( sort {$a->start <=> $b->start }  $seq1->all_SeqFeatures() ) {
+
+              my $aa1 = $feat->primary_tag();
+              my $col = $feat->start();
+
+              my $aa2 = uc substr($query_seq->seq, $col-1, 1);
+              unless($aa1 eq $aa2) {
+                  $mismatch = 1;
+                  last;
+
+              }
+
+           }
+
+           #Store seq1 if all active site residues are present in seq1
+           unless($mismatch) {
+              $aligns_with->add_seq($seq1);
+           }
+       }
+
+
+
+       $num_seq = $aligns_with->num_sequences();
+       return unless($num_seq);
+       my (%seq_to_remove, %seq_to_rem);  #two hashes used to collect seq that need removing
+
+
+        #if query seq matches more than one pattern remove subpatterns and any patterns that overlap
+
+        #first remove sub pat
+        if($num_seq>1) {
+           foreach my $sequence1 ($aligns_with->each_seq() ) {
+              foreach my $sequence2 ($aligns_with->each_seq() ) {
+
+                   next if($sequence1 eq $sequence2);
+
+                   my (%hash1, %hash2, $num_1, $num_2, %smaller, %larger);
+                   #collect column positions
+                   foreach my $feat1 ($sequence1->all_SeqFeatures() ) {
+                       $hash1{$feat1->start} =1;
+                       $num_1++;
+                   }
+                   foreach my $feat2 ($sequence2->all_SeqFeatures() ) {
+                       $hash2{$feat2->start} =1;
+                       $num_2++;
+                   }
+
+
+                   #see if one is a subpattern of the other
+                   my $diff=0;
+                   unless($num_1 eq $num_2) {
+
+                       my $remove_seq;
+
+                       if($num_1 > $num_2) {
+                           %smaller = %hash2;
+                           %larger = %hash1;
+                           $remove_seq = $sequence2;
+
+                       }
+                       else {
+                           %smaller = %hash1;
+                           %larger = %hash2;
+                           $remove_seq = $sequence1;
+                       }
+
+
+                       foreach my $key (keys %smaller) {
+                           $diff = 1 unless(exists($larger{$key}));  #diff is true if it is not a subpattern
+                       }
+
+
+                       $seq_to_rem{$remove_seq}= $remove_seq unless($diff) ;
+                       next unless($diff);
+                   }
+             }
+
+           }
+         }
+
+         #Now remove any patterns which need removing
+         foreach my $remove (keys %seq_to_rem) {
+           $aligns_with->remove_seq($seq_to_rem{$remove});
+         }
+
+
+         unless($num_seq >=1) {
+            die "FATAL: All sequences that align with active site sequences have been removed - this should never happen\n";
+         }
+
+
+
+        $num_seq = $aligns_with->num_sequences();
+        #and then any patterns that overlap
+        if($num_seq>1) {
+
+           foreach my $sequence1 ($aligns_with->each_seq() ) {
+
+              foreach my $sequence2 ($aligns_with->each_seq() ) {
+                   next if($sequence1 eq $sequence2);
+
+                   my ($seq1_st, $seq1_en, $seq2_st, $seq2_en);
+
+                   my (%hash1, %hash2, $num_1, $num_2, %smaller, %larger);
+
+                   #see if patterns overlap - find pattern start ends and collect column positions
+                   foreach my $feat1 ($sequence1->all_SeqFeatures() ) {
+
+                       $seq1_st = $feat1->start() if(!$seq1_st or $feat1->start() < $seq1_st);
+                       $seq1_en = $feat1->start() if(!$seq1_en or $feat1->start() > $seq1_en);
+                   }
+
+                   foreach my $feat2 ($sequence2->all_SeqFeatures() ) {
+
+                       $seq2_st = $feat2->start() if(!$seq2_st or $feat2->start() < $seq2_st);
+                       $seq2_en = $feat2->start() if(!$seq2_en or $feat2->start() > $seq2_en);
+                   }
+
+                   #then see if patterns overlap - remove sequence with pattern of least identity
+                   if(($seq1_st >= $seq2_st and $seq1_st <= $seq2_en) or ($seq2_st >= $seq1_st and $seq2_st <= $seq1_en)) {
+                       my $remove = _identity($query_seq, $sequence1, $sequence2);
+                       $seq_to_remove{$remove}= $remove;
+                   }
+             }
+
+           }
+         }
+
+         #Now remove any patterns which need removing
+         foreach my $remove (keys %seq_to_remove) {
+           $aligns_with->remove_seq($seq_to_remove{$remove});
+           $num_seq = $aligns_with->num_sequences();
+           last if($num_seq eq "1"); #just in case the % identities are identical
+         }
+
+
+         $num_seq = $aligns_with->num_sequences();
+         unless($num_seq >=1) {
+            die "FATAL: All sequences that align with active site sequences have been removed - this should never happen\n";
+         }
+
+
+
+           #Add features to seq
+           foreach my $sequence ($aligns_with->each_seq() ) {
+                foreach my $feat ($sequence->all_SeqFeatures() ) {
+
+                   my $actual_pos = $query_seq->location_from_column($feat->start);
+                   $actual_pos = $actual_pos->start();
+
+
+                   push(@as_res, $actual_pos);
+
+ 
+
+               }
+           }
+           return \@as_res
+
+}
+
+
+=head2 _identity
+
+ Title    : _identity
+ Usage    : _identity($sequence1 , $sequence2, $sequence3)
+ Function : Identifies seq with lowest % identity to sequence1
+ Returns  : The sequence which has the lowest % id to sequence 1
+ Args     : sequence1, sequence2, sequence3.
+
+=cut
+
+
+sub _identity {
+    my $seq1 = shift;
+    my @aligns_with = @_;
+          my $lower_identity=100;
+          my $lower_identity_seq;
+          foreach my $s (@aligns_with) {
+             my $tmp_aln = new Bio::SimpleAlign;
+             $tmp_aln->add_seq($s);
+             $tmp_aln->add_seq($seq1);
+
+             my $identity = $tmp_aln->percentage_identity();
+             if($identity < $lower_identity) {
+                 $lower_identity = $identity;
+                 $lower_identity_seq = $s;
+             }
+
+          }
+          return $lower_identity_seq;
+}
+
+=head1 COPYRIGHT
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk),
+         Jaina Mistry (jm14@sanger.ac.uk)
+
+This is free software; you can redistribute it and/or modify it under
+the terms of the GNU General Public License as published by the Free Software
+Foundation; either version 2 of the License, or (at your option) any later
+version.
+
+This program is distributed in the hope that it will be useful, but WITHOUT
+ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+details.
+
+You should have received a copy of the GNU General Public License along with
+this program. If not, see <http://www.gnu.org/licenses/>.
+
+=cut
+
+1;
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMM.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMM.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,266 @@
+# HMM.pm
+#
+# Author:        finnr
+# Maintainer:    $Id: HMM.pm,v 1.1 2009-10-08 12:27:28 jt6 Exp $
+# Version:       $Revision: 1.1 $
+# Created:       Nov 24, 2008
+# Last Modified: $Date: 2009-10-08 12:27:28 $
+=head1 NAME
+
+Template - a short description of the class
+
+=cut
+
+package Bio::Pfam::HMM::HMM;
+
+=head1 DESCRIPTION
+
+A more detailed description of what this class does and how it does it.
+
+$Id: HMM.pm,v 1.1 2009-10-08 12:27:28 jt6 Exp $
+
+=head1 COPYRIGHT
+
+File: HMM.pm
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+ This is free software; you can redistribute it and/or
+ modify it under the terms of the GNU General Public License
+ as published by the Free Software Foundation; either version 2
+ of the License, or (at your option) any later version.
+ 
+ This program is distributed in the hope that it will be useful,
+ but WITHOUT ANY WARRANTY; without even the implied warranty of
+ MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ GNU General Public License for more details.
+ 
+ You should have received a copy of the GNU General Public License
+ along with this program; if not, write to the Free Software
+ Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.
+ or see the on-line version at http://www.gnu.org/copyleft/gpl.txt
+ 
+=cut
+
+use strict;
+use warnings;
+
+use Moose;
+use Moose::Util::TypeConstraints;
+use Carp;
+
+#-------------------------------------------------------------------------------
+
+=head1 METHODS
+
+=cut
+
+
+subtype 'hmmVersion'
+  => as Str
+  => where { $_ =~ m/^HMMER3\/f\s+\[3\.\d+[ab](\d+)?\s+|\s+\[.*\]/ }
+  => message { "|$_| does not look like as HMMER3 version" };
+
+subtype 'hmmName'
+  => as Str
+  => where { $_ =~ m/\S{1,15}/ }
+  => message { "|$_| does not look like Pfam name or SEED" };
+
+subtype 'hmmAcc'
+  => as Str
+  => where { $_ =~ m/PF\d{5}/ }
+  => message { "|$_| does not look like Pfam accession" };
+
+
+subtype 'hmmAlpha'
+  => as Str
+  => where { $_ eq 'amino' or $_ eq 'nucleic'  }
+  => message { "|$_| does not look like a HMMER3 alphabet" };
+
+
+subtype 'hmmMsvStats'
+  => as HashRef
+  => where { defined ($_->{mu}) and defined ($_->{lambda}) and ($_->{lambda} <= 0.8) and ($_->{lambda} >= 0.5) }
+  => message { "Mu |$_->{mu}| and lambda |$_->{lambda}| must be defined and lambda must be between 0.5 and 0.8" };
+
+  
+subtype 'hmmViterbiStats'
+  => as HashRef
+  => where { defined ($_->{mu}) and defined ($_->{lambda}) and ($_->{lambda} <= 0.8) and ($_->{lambda} >= 0.5) }
+  => message { "Mu |$_->{mu}| and lambda |$_->{lambda}| must be defined and lambda must be between 0.5 and 0.8" };
+
+subtype 'hmmForwardStats'
+  => as HashRef
+  => where { defined ($_->{tau}) and defined ($_->{lambda}) and ($_->{lambda} <= 0.8) and ($_->{lambda} >= 0.5) }
+  => message { "Tau |$_->{tau}| and lambda |$_->{lambda}| must be defined and lambda must be between 0.5 and 0.8" };
+  
+has 'version' => (
+  isa      => 'hmmVersion',
+  is       => 'rw',
+  required => 1
+);
+
+has 'name' => (
+  isa => 'hmmName',
+  is  => 'rw',
+  required => 1
+);
+
+has 'accession' => (
+  isa => 'hmmAcc',
+  is  => 'rw'
+);
+
+has 'description' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has 'length' => (
+  isa  => 'Int',
+  is   => 'rw',
+  required => 1
+);
+
+has 'alpha' => (
+  isa  => 'hmmAlpha',
+  is   => 'rw',
+  required => 1,
+);
+
+has 'rf' => (
+  isa  => 'Bool',
+  is   => 'rw',
+  required => 1
+);
+
+has 'mm' => (
+  isa  => 'Bool',
+  is   => 'rw',
+);
+
+has 'cons' => (
+  isa  => 'Bool',
+  is   => 'rw',
+);
+
+has 'cs' => (
+  isa  => 'Bool',
+  is   => 'rw',
+  required => 1
+);
+
+has 'map' => (
+  isa  => 'Bool',
+  is   => 'rw',
+  required => 1
+);
+
+has 'date' => (
+  isa  => 'Str',
+  is   => 'rw',
+  required => 1
+);
+
+has 'buildLine' => (
+  isa => 'HashRef[Str]',
+  is  => 'rw',
+  required => 1,
+  default => sub { {} },
+);
+
+has 'searchMethod' => (
+  isa => 'Str',
+  is  => 'rw',
+);
+
+has 'nSeq' => (
+  isa  => 'Int',
+  is   => 'rw',
+  required => 1
+);
+
+has 'msvStats' => (
+  isa => 'hmmMsvStats',
+  is => 'rw',
+  required => 1
+);
+
+has 'viterbiStats' => (
+  isa => 'hmmViterbiStats',
+  is => 'rw',
+  required => 1
+);
+
+has 'forwardStats' => (
+  isa => 'hmmForwardStats',
+  is => 'rw',
+  required => 1
+);
+
+
+has 'effn' => (
+  isa  => 'Num',
+  is   => 'rw',
+  required => 1
+);
+
+has 'cksum' => (
+  isa => 'Int',
+  is  => 'rw',
+  required => 1
+);
+
+has 'seqGA' => (
+  isa => 'Num',
+  is  => 'rw',
+);
+
+has 'domGA' => (
+  isa => 'Num',
+  is  => 'rw',
+);
+
+has 'seqTC' => (
+  isa => 'Num',
+  is  => 'rw',
+);
+
+has 'domTC' => (
+  isa => 'Num',
+  is  => 'rw',
+);
+
+has 'seqNC' => (
+  isa => 'Num',
+  is  => 'rw',
+);
+
+has 'domNC' => (
+  isa => 'Num',
+  is  => 'rw',
+);
+
+has 'emissionLines' => (
+  isa => 'ArrayRef[ArrayRef]',
+  is  => 'rw',
+  default => sub { [] },
+);
+
+has 'mapPos'=> (
+  isa => 'ArrayRef[Int]',
+  is  => 'rw',
+  default => sub{ [] }
+);
+
+has 'compLines' => (
+  isa => 'ArrayRef[Str]',
+  is  => 'rw',
+  default => sub { [] },
+);
+
+__PACKAGE__->meta->make_immutable;
+1;
+
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMMIO.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMMIO.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,329 @@
+# HMM.pm
+#
+# Author:        finnr
+# Maintainer:    $Id: HMMIO.pm,v 1.3 2010-01-12 17:00:26 jm14 Exp $
+# Version:       $Revision: 1.3 $
+# Created:       Nov 24, 2008
+# Last Modified: $Date: 2010-01-12 17:00:26 $
+=head1 NAME
+
+Template - a short description of the class
+
+=cut
+
+package Bio::Pfam::HMM::HMMIO;
+
+=head1 DESCRIPTION
+
+A more detailed description of what this class does and how it does it.
+
+$Id: HMMIO.pm,v 1.3 2010-01-12 17:00:26 jm14 Exp $
+
+=head1 COPYRIGHT
+
+File: HMM.pm
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+ This is free software; you can redistribute it and/or
+ modify it under the terms of the GNU General Public License
+ as published by the Free Software Foundation; either version 2
+ of the License, or (at your option) any later version.
+ 
+ This program is distributed in the hope that it will be useful,
+ but WITHOUT ANY WARRANTY; without even the implied warranty of
+ MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ GNU General Public License for more details.
+ 
+ You should have received a copy of the GNU General Public License
+ along with this program; if not, write to the Free Software
+ Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.
+ or see the on-line version at http://www.gnu.org/copyleft/gpl.txt
+ 
+=cut
+
+use strict;
+use warnings;
+
+use Moose;
+use Moose::Util::TypeConstraints;
+use Carp;
+use Bio::Pfam::HMM::HMM;
+
+#-------------------------------------------------------------------------------
+
+=head1 METHODS
+
+=cut
+sub readHMM {
+  my ($this, $hmm) = @_;
+  
+  unless($hmm){
+    confess("No HMM passed in!"); 
+  }
+  chomp($hmm);
+  
+  my @input;
+  if(ref($hmm) eq 'GLOB'){
+    @input = <$hmm>;
+  }elsif($hmm !~ /\n/ and -e $hmm and -s $hmm){
+    #Assume that we have a filename and try and open it;
+    open(HMM, $hmm) || confess("Could not open $hmm:[$!]");
+    @input = <HMM>;
+  }else{
+    @input = split(/\n/, $hmm); 
+  }
+  
+  
+  
+  #Parse the header section!  
+  #HMMER3/f [3.1b1 | May 2013]
+  #NAME  SEED
+  #ACC   PF000001.1
+  #DESC  A description
+  #LENG  55
+  #ALPH  amino
+  #RF    no
+  #MM    no
+  #CONS  yes
+  #CS    no
+  #MAP   yes
+  #DATE  Fri Nov 21 09:58:16 2008
+  #COM   [1] /Users/finnr/Work/Software/hmmer-3.0.20081101/bin/hmmbuild -o hmmbuild.log HMM SEED
+  #NSEQ  279
+  #EFFN  4.966292
+  #STATS LOCAL MSV      -11.4716  0.69948
+  #STATS LOCAL VITERBI  -12.3713  0.69948
+  #STATS LOCAL FORWARD   -5.5807  0.69948
+
+  #To add GA, TC, NC, CKSUM, DESC
+  my($objHash);
+  my $i =0; 
+  foreach ( @input ){  
+    if(my ($version) = $_ =~ /(HMMER3.*)/){
+      $objHash->{version} = $version;
+    }elsif(my ($acc) = $_ =~ /^ACC\s+(PF\d+\.\d+)$/){
+      $objHash->{accession} = $acc;
+    }elsif(/NAME\s+(\S+)/){ 
+      $objHash->{name} =  $1 ;
+    }elsif(/DESC\s+(.*)/){ 
+      $objHash->{description} =   $1 ;
+    }elsif(my ($length) = $_ =~ /^LENG\s+(\d+)/){
+      $objHash->{length} = $length;
+    }elsif( my ($alpha) = $_ =~ /^ALPH\s+(\S+)/){
+      $objHash->{alpha} = $alpha;
+    }elsif( my ($rf) = $_ =~ /^RF\s+(no|yes)/){
+      $objHash->{rf} = ($rf eq "no") ? 0 : 1; 
+    }elsif( my ($mm) = $_ =~ /^MM\s+(no|yes)/){
+      $objHash->{mm} = ($mm eq "no") ? 0 : 1; 
+    }elsif( my ($cons) = $_ =~ /^CONS\s+(no|yes)/){
+      $objHash->{cons} = ($cons eq "no") ? 0 : 1; 
+    }elsif(my ($cs) = $_ =~ /^CS\s+(no|yes)/ ){
+      $objHash->{cs} =  ($cs eq "no") ? 0 : 1; 
+    }elsif(my ($map) = $_ =~ /^MAP\s+(no|yes)/){
+      $objHash->{map} = ($map eq "no") ? 0 : 1; 
+    }elsif(my ($date) = $_ =~ /^DATE\s+(.*)/){
+      $objHash->{date} =  $date; 
+    }elsif(my ($sm) = $_ =~ /^SM\s+(.*)/){
+      $objHash->{searchMethod} =  $sm; 
+    
+    }elsif(my ($options, $hmmName, $alignName) = $input[$i] =~ /^BM.*hmmbuild(.*)? (\S+) (\S+)$/){
+      $objHash->{buildLine} = { cmd     => 'hmmbuild', 
+                                options => $options,
+                                name    => $hmmName,
+                                align   => $alignName } ;
+    }elsif(my($noSeqs) = $_ =~ /^NSEQ\s+(\d+)/){
+      $objHash->{nSeq} = $noSeqs;
+    }elsif( my($effn) = $_ =~ /^EFFN\s+(\d+\.\d+)/){
+       #EFFN  4.966292
+      $objHash->{effn} =  $effn ;
+    }elsif( my ( $cksum ) = $_ =~ /^CKSUM (\d+)/){
+      $objHash->{cksum} = $cksum ;
+    }elsif(/GA\s+(\S+)\s+(\S+)\;/){ 
+      $objHash->{seqGA} = $1;
+      $objHash->{domGA} = $2;
+    }elsif(/TC\s+(\S+)\s+(\S+)\;/){ 
+      $objHash->{seqTC} = $1;
+      $objHash->{domTC} = $2;
+    }elsif(/NC\s+(\S+)\s+(\S+)\;/){ 
+      $objHash->{seqNC} = $1;
+      $objHash->{domNC} = $2;
+    }elsif( my ($msv_mu, $msv_lambda ) = $_ =~ /^STATS LOCAL MSV\s+(\S+)\s+(0\.\d+)/){
+	$objHash->{msvStats} = { mu => $msv_mu, lambda => $msv_lambda};
+    }elsif( my ($viterbi_mu, $viterbi_lambda ) = $_ =~ /^STATS LOCAL VITERBI\s+(\S+)\s+(0\.\d+)/){
+	$objHash->{viterbiStats} = { mu => $viterbi_mu, lambda => $viterbi_lambda };
+    }elsif( my ($forward_tau, $forward_lambda ) = $_ =~ /^STATS LOCAL FORWARD\s+(\S+)\s+(0\.\d+)/){
+	$objHash->{forwardStats} = {tau => $forward_tau, lambda => $forward_lambda};
+    }elsif( $_ =~ /^HMM\s+A/){
+      last;
+    }else{
+      confess("Got a bad HMM header line:$input[$i]\n"); 
+    }
+    $i++;
+  }
+
+  my $hmmObj = Bio::Pfam::HMM::HMM->new($objHash);
+  
+  
+  #The next two lines are stand lines
+  #HMM          A        C        D        E        F        G        H        I        K        L        M        N        P        Q        R        S        T        V        W        Y   
+  #          m->m     m->i     m->d     i->m     i->i     d->m     d->d
+  $i++;
+
+
+  #Add the comp line
+  for( my $line = 0; $line <=2; $line++){
+    $i++;
+    my @l = split(/\s+/, $input[$i]);
+    my @c;
+    if($line == 0 ){
+      @c = @l[2..21];
+    }elsif( $line == 1){
+      @c = @l[1..20]; 
+    }elsif($line == 2){
+      @c = @l[1..7];  
+    }
+    $hmmObj->compLines->[$line] = \@c;
+  }
+  
+
+  
+  for(my $pos = 0; $pos < $hmmObj->length; $pos++){
+    #There are three lines per position - match emission line, insert emission line, state transition line
+    for( my $line = 0; $line <=2; $line++){
+      $i++;
+      my @l = split(/\s+/, $input[$i]);
+      my @e;
+      if($line == 0 ){
+        @e = @l[2..21];
+        if($hmmObj->map){
+           $hmmObj->mapPos->[$pos] = $l[22];
+        } 
+      }elsif( $line == 1){
+        @e = @l[1..20]; 
+      }elsif($line == 2){
+        @e = @l[1..7];  
+      }
+      $hmmObj->emissionLines->[$pos]->[$line] = \@e;
+    }
+  }
+  
+  if($input[$i++] =~ /^\/\/$/){
+    confess("Expected file terminator //, but got $input[$i]\n"); 
+  }
+ 
+  #No veryifiy that we have COMP line and the the number of emissionlines is equivalent to length 
+  unless(scalar( @{ $hmmObj->emissionLines } ) == $hmmObj->length){
+    confess("Number of emssionLines does not match the length of the model, got ".scalar( @{ $hmmObj->emissionLines} ).
+        " expected ".$hmmObj->length);  
+  }
+  
+  unless($hmmObj->compLines){
+    confess("No compLine set on HMM"); 
+  }
+  
+  if($hmmObj->map){
+    unless(scalar(@{$hmmObj->mapPos}) == $hmmObj->length ){
+      confess("HMM object had map set, but the number of map positions does not match the length of the HMM");  
+    }; 
+  }
+  return $hmmObj;  
+}
+
+
+
+sub writeHMM {
+  my ($this, $hmm, $hmmObj) = @_;
+  
+  unless($hmm){
+    confess("No HMM out file passed in!"); 
+  }
+  
+  unless(ref($hmm) eq 'GLOB'){
+    my $hmmFile = $hmm;
+    $hmm = undef;
+    #Assume that we have a filename and try and open it;
+    open($hmm, ">$hmmFile") || confess("Could not open $hmmFile:[$!]");
+  }
+
+  print  $hmm $hmmObj->version."\n";
+  printf $hmm ("%-5s %s\n", "NAME", $hmmObj->name);
+  printf $hmm ("%-5s %s\n", "ACC",  $hmmObj->accession) if($hmmObj->accession);
+  printf $hmm ("%-5s %s\n", "DESC", $hmmObj->description) if($hmmObj->description);
+  printf $hmm ("%-5s %d\n", "LENG", $hmmObj->length);
+  printf $hmm ("%-5s %s\n", "ALPH", $hmmObj->alpha);
+  printf $hmm ("%-5s %s\n", "RF", ($hmmObj->rf ? "yes" : "no"));
+  printf $hmm ("%-5s %s\n", "MM", ($hmmObj->mm ? "yes" : "no"));
+  printf $hmm ("%-5s %s\n", "CONS", ($hmmObj->cons ? "yes" : "no"));
+  printf $hmm ("%-5s %s\n", "CS", ($hmmObj->cs ? "yes" : "no"));
+  printf $hmm ("%-5s %s\n", "MAP", ($hmmObj->map ? "yes" : "no"));
+  printf $hmm ("%-5s %s\n", "DATE", $hmmObj->date);
+  printf $hmm ("%-5s %d\n", "NSEQ", $hmmObj->nSeq);
+  printf $hmm ("%-5s %f\n", "EFFN", $hmmObj->effn);
+  printf $hmm ("%-5s %d\n", "CKSUM", $hmmObj->cksum);
+  printf $hmm ("%-5s %.2f %.2f;\n", "GA", $hmmObj->seqGA, $hmmObj->domGA) if(defined($hmmObj->seqGA));
+  printf $hmm ("%-5s %.2f %.2f;\n", "TC", $hmmObj->seqTC, $hmmObj->domTC) if(defined($hmmObj->seqTC));
+  printf $hmm ("%-5s %.2f %.2f;\n", "NC", $hmmObj->seqNC, $hmmObj->domNC) if(defined($hmmObj->seqNC));
+  
+  printf $hmm ("%-5s %s %-9s %.4f  %.5f\n", "STATS", "LOCAL", "MSV", $hmmObj->msvStats->{mu},  $hmmObj->msvStats->{lambda});
+  printf $hmm ("%-5s %s %-9s %.4f  %.5f\n", "STATS", "LOCAL", "VITERBI", $hmmObj->viterbiStats->{mu},  $hmmObj->viterbiStats->{lambda});
+  printf $hmm ("%-5s %s %-9s %.4f  %.5f\n", "STATS", "LOCAL", "FORWARD", $hmmObj->forwardStats->{tau},  $hmmObj->forwardStats->{lambda});
+  
+  print $hmm <<EOF;
+HMM          A        C        D        E        F        G        H        I        K        L        M        N        P        Q        R        S        T        V        W        Y   
+            m->m     m->i     m->d     i->m     i->i     d->m     d->d
+EOF
+  
+  printf $hmm ("%7s ", "COMPO");
+   foreach my $s (@{$hmmObj->compLines->[0]}){
+       printf $hmm ("  %7s", $s);
+    }
+    print $hmm "\n";
+     
+    print $hmm (" " x 8);
+    foreach my $s (@{$hmmObj->compLines->[1]}){
+       printf $hmm ("  %7s", $s);
+    }
+    print $hmm "\n";
+    
+    print $hmm (" " x 8);
+    foreach my $s (@{$hmmObj->compLines->[2]}){
+       printf $hmm ("  %7s", $s);
+    }
+    print $hmm "\n";
+    
+  
+  my $pos = 1;
+  foreach my $el (@{ $hmmObj->emissionLines }){
+    printf $hmm ("%7s ", $pos);
+    foreach my $s (@{$el->[0]}){
+       printf $hmm ("  %7s", $s);
+    }
+    if($hmmObj->map){
+      printf $hmm ("%7s - -\n", $hmmObj->mapPos->[$pos - 1]);  
+    }else{
+      print $hmm "\n";
+    } 
+    print $hmm (" " x 8);
+    foreach my $s (@{$el->[1]}){
+       printf $hmm ("  %7s", $s);
+    }
+    print $hmm "\n";
+    print $hmm (" " x 8);
+    foreach my $s (@{$el->[2]}){
+       printf $hmm ("  %7s", $s);
+    }
+    print $hmm "\n"; 
+    $pos++; 
+  }
+  
+
+  print $hmm "//\n";
+}
+
+
+
+1;
+
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMMMatch.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMMMatch.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,62 @@
+
+package Bio::Pfam::HMM::HMMMatch;
+
+use strict;
+use warnings;
+
+use Moose;
+use Moose::Util::TypeConstraints;
+
+
+subtype 'evalue'
+  => as Str
+  => where { $_ =~ m/^(\d+(\.\d+){0,1}e[+|-]\d+|\d+\.\d+|\d+)$/ }
+  => message { "$_ does not look like an evalue" };
+
+has 'evalue' => (
+  isa       => 'evalue', 
+  is        => 'rw',
+  required  => 1
+);
+
+has 'bits' => (
+  isa => 'Str',
+  is  => 'rw',
+  required => 1
+);
+
+has 'name' => (
+  isa => 'Str',
+  is  => 'rw',
+  required => 1
+);
+
+has bias => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+  __PACKAGE__->meta->make_immutable;
+
+=head1 COPYRIGHT
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+This is free software; you can redistribute it and/or modify it under
+the terms of the GNU General Public License as published by the Free Software
+Foundation; either version 2 of the License, or (at your option) any later
+version.
+
+This program is distributed in the hope that it will be useful, but WITHOUT
+ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+details.
+
+You should have received a copy of the GNU General Public License along with
+this program. If not, see <http://www.gnu.org/licenses/>.
+
+=cut
+
+1;
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMMResults.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMMResults.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,582 @@
+# Bio::Pfam::HMM::HMMResults.pm
+#
+# Author:        finnr
+# Maintainer:    $Id: HMMResults.pm,v 1.3 2009-12-15 14:38:08 jt6 Exp $
+# Version:       $Revision: 1.3 $
+# Created:       Nov 19, 2008
+# Last Modified: $Date: 2009-12-15 14:38:08 $
+
+=head1 NAME
+
+Bio::Pfam::HMM::HMMResults - A object to represents the results from hmmsearch
+
+=cut
+
+package Bio::Pfam::HMM::HMMResults;
+
+=head1 DESCRIPTION
+
+A more detailed description of what this class does and how it does it.
+
+$Id: HMMResults.pm,v 1.3 2009-12-15 14:38:08 jt6 Exp $
+
+=head1 COPYRIGHT
+
+File: Bio::Pfam::HMM::HMMResults.pm
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk)
+
+ This is free software; you can redistribute it and/or
+ modify it under the terms of the GNU General Public License
+ as published by the Free Software Foundation; either version 2
+ of the License, or (at your option) any later version.
+ 
+ This program is distributed in the hope that it will be useful,
+ but WITHOUT ANY WARRANTY; without even the implied warranty of
+ MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ GNU General Public License for more details.
+ 
+ You should have received a copy of the GNU General Public License
+ along with this program; if not, write to the Free Software
+ Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA.
+ or see the on-line version at http://www.gnu.org/copyleft/gpl.txt
+ 
+=cut
+
+use strict;
+use warnings;
+
+use Moose;
+use Moose::Util::TypeConstraints;
+use Bio::Pfam::HMM::HMMSequence;
+use Bio::Pfam::HMM::HMMUnit;
+
+#
+#-------------------------------------------------------------------------------
+# Attributes
+
+has 'hmmerVersion' => (
+  isa       => 'Str', 
+  is        => 'rw', 
+);
+
+has 'hmmName' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has 'seqDB' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has hmmLength => (
+  isa => 'Int',
+  is  => 'rw'
+);
+
+has 'thisFile' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has seedName => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has 'seqs' => (
+  isa => 'HashRef',
+  is  => 'rw',
+  default => sub { {} },
+);
+
+has 'units' => (
+  isa => 'ArrayRef',
+  is  => 'rw',
+  default => sub { [] },
+);
+
+has 'domThr' => (
+  isa => 'Num',
+  is   => 'rw',
+  default => '25.0'
+);
+
+has 'seqThr' => (
+  isa => 'Num',
+  is  => 'rw',
+  default => '25.0'
+);
+
+has 'evalueThr' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+has 'domTC' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+has 'seqTC' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+has 'domNC' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+has 'seqNC' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+has 'randSeedNum' => (
+  isa => 'Int',
+  is  => 'rw'
+);
+
+has 'description' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has 'seqName' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has 'seqLength' => (
+  isa => 'Int',
+  is  => 'rw'
+);
+
+
+has 'eof' => (
+  isa => 'Int',
+  is  => 'rw',
+  default => 0
+);
+
+has 'program' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+=head1 METHODS
+
+=head2 addHMMSeq 
+
+  Title    : addHMMSeq
+  Usage    : $hmmRes->addHMMSeq( $hmmSeqObj )
+  Function : Adds a Bio::Pfam::HMM::HMMSequence object to the results object 
+  Args     : A Bio::Pfam::HMM::HMMSequence object
+  Returns  : nothing
+  
+=cut
+
+sub addHMMSeq {
+  my( $self, $hmmSeq ) = @_;
+
+  unless($hmmSeq->isa('Bio::Pfam::HMM::HMMSequence')){
+    die 'Trying to add a non Bio::Pfam::HMM::HMMSequence object';  
+  }
+
+  if($self->seqs){
+    if($self->seqs->{$hmmSeq->name}){
+      die "Trying to add the same sequence twice"; 
+    }
+  }
+  
+  $self->seqs->{$hmmSeq->name} = $hmmSeq;
+}
+
+
+=head2 eachHMMSeq 
+
+  Title    : eachHMMSeq
+  Usage    : my @seqs = $hmmRes->eachHMMSeq
+  Function : Returns an array reference containing the references to all of the
+           : Bio::Pfam::HMM::HMMSequence objects stored in the HMMResults object.
+  Args     : None
+  Returns  : Array reference
+  
+=cut
+
+sub eachHMMSeq {
+  my ($self ) = @_;
+  my @seqs;
+  my $seqRefs = $self->seqs;
+  foreach my $n (keys %{ $seqRefs }){
+    push(@seqs, $seqRefs->{$n});
+  } 
+  return(\@seqs);
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 addHMMUnit 
+
+  Title    : addHMMUnit
+  Usage    : $hmmRes 
+  Function : Adds HMM units (the actual region hit) to the HMMSequence in the object
+           : and for convenience to the the results sets. All we store are duplicates
+           : of the references. 
+  Args     : A Bio::Pfam::HMM:HMMUnit
+  Returns  : Nothing
+  
+=cut
+
+sub addHMMUnit {
+  my ($self, $hmmUnit) = @_;
+  
+  unless($hmmUnit->isa('Bio::Pfam::HMM::HMMUnit')){
+    die "Trying to add an non-Bio::Pfam::HMM::HMMUnit\n";
+  }
+  
+  if($self->seqs){
+    if($self->seqs->{$hmmUnit->name}){
+      $self->seqs->{$hmmUnit->name}->addHMMUnit($hmmUnit);
+    }else{
+      warn "Could not add hmmUnit as the sequence has not been added\n";
+    }
+  }
+  
+  #More conveinence we store the point to the hmmunit in an array
+  push(@{$self->units},$hmmUnit); 
+}
+
+
+#-------------------------------------------------------------------------------
+
+=head2  domainBitsCutoffFromEvalue
+
+  Title    : domainBitsCutoffFromEvalue
+  Usage    : $hmmRes->domainBitsCutoffFromEvalue(0.01)
+  Function : From the supplied evalue, it scans through all of the evalues in the results
+           : and calulates the bits score.  
+  Args     : An evalue. 
+  Returns  : A bits score. If no evalue is specified, returns nothing
+  
+=cut
+
+sub domainBitsCutoffFromEvalue {
+  my ($self, $eval) = @_;
+  my ($dom,$prev,@doms,$cutoff,$sep,$seen);
+  
+  unless(defined ($eval) ){
+    warn "No evalue specified\n";
+    return; 
+  }
+
+
+  $seen = 0;
+  foreach $_ ( sort { $b->bits <=> $a->bits } @{$self->units}, @{$self->eachHMMSeq} ) {
+    if( $_->evalue > $eval ) {
+	    $seen = 1;
+	    $dom = $_;
+	    last;
+	  } 
+	  $prev = $_;
+  }
+    
+  if( ! defined $prev || $seen == 0) {
+	  carp("Evalue is either above or below the list...");
+	  return undef;
+  }
+
+  $sep = $prev->bits - $dom->bits ;
+    
+  if( $sep < 1 ) {
+	    return $prev->bits();
+  }
+  if( $dom->bits < 25 && $prev->bits > 25 ) {
+	  return 25;
+  }
+
+  return $dom->bits + sprintf("%.1f",$sep/2);
+}
+
+
+#-------------------------------------------------------------------------------
+
+=head2 lowestTrue
+
+  Title    :
+  Usage    :  
+  Function :
+  Args     :
+  Returns  :
+  
+=cut
+
+sub lowestTrue {
+  my $self = shift;
+  
+  unless($self->domTC && $self->seqTC) {
+    unless($self->domThr and $self->seqThr){
+      die "Could not define TC as I am missing a threshold\n";
+    }
+    #Set it wildly high!
+    my ($lowSeq, $lowDom);
+    $lowSeq = $lowDom = 999999.99;  
+    
+    foreach my $seqId (keys %{$self->seqs} ){ 
+      if($self->seqs->{$seqId}->bits >= $self->seqThr){
+        #Is this the lowest sequence thresh
+        if($self->seqs->{$seqId}->bits < $lowSeq){
+          $lowSeq = $self->seqs->{$seqId}->bits; 
+        }
+        #For each of the regions found on the sequence, look to see if the match is great
+        #than the domain threshold.  If it is, is it lower than we we have seen previously    
+        foreach my $unit (@{ $self->seqs->{$seqId}->hmmUnits } ){
+          if( $unit->bits() >= $self->domThr && $unit->bits() < $lowDom ) {
+		        $lowDom  = $unit->bits;
+          }
+        } 
+      }
+      
+    }
+    $self->domTC($lowDom);
+    $self->seqTC($lowSeq);
+  }
+  return($self->seqTC, $self->domTC);
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 highestNoise
+
+  Title    :
+  Usage    :  
+  Function :
+  Args     :
+  Returns  :
+  
+=cut
+
+sub highestNoise {
+  my $self = shift;
+  
+  #See if it is already set
+  unless($self->domNC && $self->seqNC) {
+    unless($self->domThr and $self->seqThr){
+      die "Could not define TC as I am missing a threshold\n";
+    }
+    
+    #Set it wildly low
+    my ($highSeq, $highDom);
+    $highSeq = $highDom = -999999.99;  
+    
+    foreach my $seqId (keys %{$self->seqs} ){
+      
+      if($self->seqs->{$seqId}->bits < $self->seqThr){
+        #Is this the highest sequence thres below the cut-off
+        if($self->seqs->{$seqId}->bits > $highSeq){
+          $highSeq = $self->seqs->{$seqId}->bits; 
+        }
+      }
+      
+      #For each of the regions found on the sequence, look to see if the match is great
+      #than the domain threshold.  If it is, is it lower than we we have seen previously    
+      foreach my $unit (@{ $self->seqs->{$seqId}->hmmUnits } ){
+        if( $unit->bits < $self->domThr && $unit->bits > $highDom ) {
+		      $highDom  = $unit->bits;
+        }
+      }
+    }
+    $self->domNC($highDom);
+    $self->seqNC($highSeq); 
+  }
+
+  return($self->seqNC, $self->domNC);
+}
+
+
+sub applyEdits {
+  my ($self, $edits, $removeBadEd) = @_;
+
+  my @validEd; #If removeBadEd flag is on, collect all the valid ED lines in this array and return at end of sub 
+  foreach my $e (@$edits){
+    #{ seq => $1, oldFrom => $2, oldTo => $3, newFrom => $5, newTo => $6 }  
+    if($self->seqs->{$e->{seq}}){
+      my $matched = 0;
+      foreach my $u (@{ $self->seqs->{ $e->{seq} }->hmmUnits }){
+          if($u->envFrom == $e->{oldFrom} and $u->envTo == $e->{oldTo}) {
+	    $matched = 1; #HMM unit found
+
+            if(defined $e->{newFrom} and $e->{newTo}){
+	     
+	      #Check co-ordinates of new start and end positions are in range
+	      if( $e->{newFrom} < $u->{envFrom} or $e->{newTo} > $u->{envTo} or $e->{newFrom} > $e->{newTo}) {
+		if($removeBadEd) {
+		  print "Removing ED line due to out of range co-ordinates: " . $e->{seq}."/".$e->{newFrom}."-".$e->{newTo}. "\n";
+		}
+		else {
+		  warn $e->{seq}."/".$e->{newFrom}."-".$e->{newTo}." contains out of range co-ordinates - bad ED line\n";
+		}
+		last;
+	      }
+
+              #Modify the start end positions
+              $u->envFrom($e->{newFrom});
+              $u->envTo($e->{newTo});
+              
+              #Check that the ali-positions are still okay
+              if($u->seqFrom < $e->{newFrom}){
+                $u->seqFrom($e->{newFrom});  
+              }
+              if($u->seqTo > $e->{newTo}){
+                $u->seqTo($e->{newTo});  
+              }
+            }else{
+              #Set the score so low it will never get in the align
+              $u->bits(-999999.99);
+            }
+
+	    push(@validEd, $e) if($removeBadEd);  
+            last;    
+          }  
+      }
+      unless($matched){ #HMM unit not found - bad ED
+	if($removeBadEd) {
+	  print "Removing ED line for invalid hmm unit: " . $e->{seq}."/".$e->{oldFrom}."-".$e->{oldTo}. "\n";
+	}
+	else {
+	  warn $e->{seq}."/".$e->{oldFrom}."-".$e->{oldTo}." does not appear in the list of hmm units - bad ED line\n";
+	}
+      }
+    }else{ #Sequence not found - bad ED
+      if($removeBadEd) {
+	print "Removing ED line for invalid hmm unit: " . $e->{seq}."/".$e->{oldFrom}."-".$e->{oldTo}. "\n";
+      }
+      else {
+	warn $e->{seq}." does not appear in the list of hmm units - bad ED line\n";  
+      }
+    }
+  }
+  return(\@validEd) if($removeBadEd);
+  
+}
+
+sub remove_overlaps_by_clan {
+
+    my ($self, $clanmap, $nested) = @_;
+
+    my $new = Bio::Pfam::HMM::HMMResults->new;
+    $new->seqName($self->seqName);
+   
+    foreach my $unit ( sort { $a->evalue <=> $b->evalue }  @{ $self->units } ) {
+
+        #check if it overlaps before adding
+	my $o;
+	
+	foreach my $u ( @{ $new->units } ) {
+	    
+	    if( exists($clanmap->{$unit->name}) and exists($clanmap->{$u->name}) and ($clanmap->{$unit->name} eq $clanmap->{$u->name}) ) {
+		if( overlap( $unit, $u ) ) {
+		    if(exists($$nested{$unit->name}{$u->name})) {
+			next;
+		    }
+		    else {
+			$o=1;
+			last;
+		    }
+		}
+		
+	    }
+	}
+	unless($o) {
+	    if(! $new->seqs->{$unit->name}) {
+		
+		$new->addHMMSeq( Bio::Pfam::HMM::HMMSequence->new( {  name       => $self->seqs->{$unit->name}->name,
+								      desc       => $self->seqs->{$unit->name}->desc,
+								      bits       => $self->seqs->{$unit->name}->bits,
+								      evalue     => $self->seqs->{$unit->name}->evalue,
+								      numberHits => $self->seqs->{$unit->name}->numberHits}) );
+	    
+	    }
+	    $new->addHMMUnit($unit);
+	}
+
+    }
+    return $new;
+}
+
+
+
+sub overlap {
+    # does unit1 overlap with unit2?
+    my $unit1 = shift;
+    my $unit2 = shift;
+    my( $u1, $u2 ) = sort { $a->seqFrom <=> $b->seqFrom } ( $unit1, $unit2 );
+
+
+    if( $u2->seqFrom <= $u1->seqTo ) {
+        return 1;
+    } 
+
+    return 0;
+}
+
+
+sub results {
+  my ( $self, $pfamScanData, $e_value ) = @_;
+
+  my @results = ();
+  foreach my $unit ( sort { $a->seqFrom <=> $b->seqFrom } @{ $self->units } ) {    
+
+    my $pfamB = $unit->name =~ /^Pfam-B/;
+
+    #Filter results based on thresholds
+    if ( $unit->name =~ /^Pfam-B/ ) {
+      next unless ( $self->seqs->{$unit->name}->evalue <= 0.001 and $unit->evalue <= 0.001 );
+      $pfamB = 1;
+    }
+    else {	  
+      if ( $e_value ) {
+        next unless ( $self->seqs->{$unit->name}->evalue <= $e_value and $unit->evalue <= $e_value ) ;
+      } 
+      else {
+       next unless $unit->sig;
+      }
+    }
+
+    push @results, {
+      seq          => { from => $unit->seqFrom,
+                        to   => $unit->seqTo,
+                        name => $self->seqName },
+      env          => { from => $unit->envFrom,
+                        to   => $unit->envTo },
+
+      hmm          => { from => $unit->hmmFrom,
+                        to   => $unit->hmmTo },
+
+      model_length => $pfamScanData->{_model_len}->{ $unit->name },
+      bits         => $unit->bits,
+      evalue       => $unit->evalue,
+      acc          => $pfamScanData->{_accmap}->{ $unit->name },
+      name         => $unit->name,
+      desc         => $pfamScanData->{_desc}->{ $unit->name },
+      type         => $pfamB ? undef : $pfamScanData->{_type}->{ $unit->name },
+      clan         => $pfamB ? undef : 
+                         $pfamScanData->{_clanmap}->{ $unit->name } || 'No_clan',
+
+      act_site     => $pfamB ? undef : $unit->{act_site},
+      sig          => $pfamB ? "NA" : $unit->sig,
+      align        => [ sprintf( '#HMM       %s', $unit->hmmalign->{hmm} ),
+                        sprintf( '#MATCH     %s', $unit->hmmalign->{match} ),
+                        sprintf( '#PP        %s', $unit->hmmalign->{pp} ),
+                        sprintf( '#SEQ       %s', $unit->hmmalign->{seq} ) ]
+    };
+  }
+
+  return \@results;
+}
+
+1;
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMMResultsIO.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMMResultsIO.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,1186 @@
+# HMMResultsIO.pm
+#
+# Author:        rdf
+# Maintainer:    $Id: HMMResultsIO.pm,v 1.2 2009-12-01 15:42:20 jt6 Exp $
+# Version:       $Revision: 1.2 $
+# Created:       Nov 16, 2008
+# Last Modified: $Date: 2009-12-01 15:42:20 $
+
+=head1 NAME
+
+Template - a short description of the class
+
+=cut
+
+package Bio::Pfam::HMM::HMMResultsIO;
+
+=head1 DESCRIPTION
+
+A more detailed description of what this class does and how it does it.
+
+$Id: HMMResultsIO.pm,v 1.2 2009-12-01 15:42:20 jt6 Exp $
+
+=head1 COPYRIGHT
+
+File: HMMResultsIO.pm
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+ This is free software; you can redistribute it and/or
+ modify it under the terms of the GNU General Public License
+ as published by the Free Software Foundation; either version 2
+ of the License, or (at your option) any later version.
+ 
+ This program is distributed in the hope that it will be useful,
+ but WITHOUT ANY WARRANTY; without even the implied warranty of
+ MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+ GNU General Public License for more details.
+ 
+ You should have received a copy of the GNU General Public License
+ along with this program; if not, write to the Free Software
+ Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.
+ or see the on-line version at http://www.gnu.org/copyleft/gpl.txt
+ 
+=cut
+
+use strict;
+use warnings;
+use Moose;
+use Carp;
+
+#All the things we need to objectfy the search results
+use Bio::Pfam::HMM::HMMResults;
+use Bio::Pfam::HMM::HMMSequence;
+use Bio::Pfam::HMM::HMMUnit;
+
+#-------------------------------------------------------------------------------
+
+=head1 ATTRIBUTES
+
+
+
+=cut
+
+has 'align' => (
+  isa     => 'Int',
+  is      => 'rw',
+  default => 0
+);
+
+has 'outfile' => (
+  isa     => 'Str',
+  is      => 'rw',
+  default => 'OUTPUT'
+);
+
+has 'pfamout' => (
+  isa     => 'Str',
+  is      => 'rw',
+  default => 'PFAMOUT'
+);
+
+has 'scores' => (
+  isa     => 'Str',
+  is      => 'rw',
+  default => 'scores'
+);
+
+#-------------------------------------------------------------------------------
+
+=head1 METHODS
+
+=head2 parseHMMER3
+
+  Title    : parseHMMER 
+  Usage    : $hmmResIO->parseHMMSearch( filename )
+  Function : Parse the output from a HMMER3 search results 
+  Args     : Filename containing the search 
+  Returns  : A Bio::Pfam::HMM::HMMResults object
+  
+=cut
+
+sub parseHMMER3 {
+  my ( $self, $filename ) = @_;
+  my $fh;
+ 
+  if(ref($filename) eq 'GLOB'){
+    $fh = $filename;
+  }else{
+    open( $fh, $filename ) or confess "Could not open $filename:[$!]\n";
+  }
+  
+#  open( $fh, $filename ) or confess "Could not open $filename:[$!]\n";
+  my $hmmRes = Bio::Pfam::HMM::HMMResults->new;
+  $self->_readHeader( $fh, $hmmRes );
+  $self->_readSeqHits( $fh, $hmmRes );
+  $self->_readUnitHits( $fh, $hmmRes );
+  $self->_readFooter($fh, $hmmRes);
+  return ($hmmRes);
+}
+
+
+
+sub parseMultiHMMER3 {
+  my ( $self, $filename ) = @_;
+  my $fh;
+  
+  if(ref($filename) eq 'GLOB'){
+    $fh = $filename;
+  }elsif( ref($filename) and $filename->isa('IO::File') ) {
+      $fh = $filename;
+  }else{
+    open( $fh, $filename ) or confess "Could not open $filename:[$!]\n";
+  }  
+  
+  my @hmmResAll;
+  my $program;
+  while(!eof($fh)){
+    my $hmmRes = Bio::Pfam::HMM::HMMResults->new;
+    my $eof = $self->_readHeader( $fh, $hmmRes ); 
+    last if($eof);
+    push(@hmmResAll, $hmmRes);
+    if($hmmRes->program) {
+	$program = $hmmRes->program;
+    }
+    else {
+	$hmmRes->program($program);
+    }
+    $self->_readSeqHits( $fh, $hmmRes );
+    $self->_readUnitHits( $fh, $hmmRes );
+    $self->_readFooter($fh, $hmmRes);
+  }
+  return (\@hmmResAll);
+}
+
+sub parseSplitHMMER3 {
+  my($self, $files ) = @_;
+  
+  my $hmmRes = Bio::Pfam::HMM::HMMResults->new;
+  
+  foreach my $filename (@{$files}){
+    my ($fh);
+    open( $fh, $filename ) or confess "Could not open $filename:[$!]\n";
+    $self->_readHeader( $fh, $hmmRes );
+    $self->_readSeqHits( $fh, $hmmRes );
+    $self->_readUnitHits( $fh, $hmmRes );
+    $self->_readFooter($fh, $hmmRes);
+  }
+  
+  return ( $hmmRes );
+    
+}
+
+
+#-------------------------------------------------------------------------------
+
+=head2 convertHMMSearch 
+
+  Title    : convertHMMSearch
+  Usage    : $hmmResIO->convertHMMSearch('SEARCHFILE') 
+  Function : This wraps up a couple of methods to convert the more complex hmmsearch 
+           : results in to nice clean format that we Pfam-ers are used to. 
+  Args     : The filename of the hmmsearch output file
+  Returns  : Nothing
+  
+=cut
+
+sub convertHMMSearch {
+  my ( $self, $filename ) = @_;
+
+  unless ($filename) {
+    confess "No filename passed in to convertHMMSearch\n";
+  }
+  unless ( -s $filename ) {
+    confess "$filename does not exists\n";
+  }
+
+  #Now parse in the raw HMM output and write out the results as a PFAMOUT
+  my $hmmRes = $self->parseHMMER3($filename);
+  $self->writePFAMOUT($hmmRes);
+  return $hmmRes;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 writePFAMOUT 
+
+  Title    : writePFAMOUT
+  Usage    : $hmmResIO->writePFAMOUT( $hmmRes ) 
+  Function : Writes a Bio::Pfam::HMM:HMMResults object in to a PFAMOUT file. 
+  Args     : A Bio::Pfam::HMM:HMMResults
+  Returns  : Nothing
+  
+=cut
+
+sub writePFAMOUT {
+  my ( $self, $hmmRes ) = @_;
+
+  unless ($hmmRes) {
+    confess "A Bio::Pfam::HMM::HMMResults object was not parsed in\n";
+  }
+  unless ( $hmmRes->isa("Bio::Pfam::HMM::HMMResults") ) {
+    confess("Variable passed in is not a Bio::Pfam::HMM::Results object");
+  }
+
+  my $fh;
+  open( $fh, ">" . $self->pfamout )
+    or confess "Could not open " . $self->pfamout . ":[$!]\n";
+
+  print $fh <<HEAD;
+# ===========
+# Pfam output
+# ===========
+#
+# Sequence scores
+# ---------------
+#
+# name           description                                   bits      evalue   n   exp  bias  
+ 
+HEAD
+
+  foreach
+    my $seq ( sort { $b->bits <=> $a->bits } ( @{ $hmmRes->eachHMMSeq } ) )
+  {
+    $_ = $seq->desc;
+    my ($desc) = /^(.{1,42})/;
+    $desc = uc($desc);
+    printf $fh (
+      "%-15s  %-42s %8.1f  %9s %3d %5.1f %5.1f\n",
+      $seq->name,
+      $desc,
+      $seq->bits,
+      $seq->evalue,
+      scalar( @{ $seq->hmmUnits } ),
+      defined( $seq->exp )  ? $seq->exp  : "-",
+      defined( $seq->bias ) ? $seq->bias : "-"
+    );
+  }
+
+  print $fh <<HEAD;
+#
+# Domain scores
+# -------------
+#
+# name           env-st  env-en  ali-st  ali-en  hmm-st  hmm-en   bits     evalue    hit   bias
+#
+
+HEAD
+
+  foreach my $dom ( sort { $b->bits <=> $a->bits } @{ $hmmRes->units } ) {
+    
+    
+    printf $fh (
+      "%-15s  %6d  %6d  %6d  %6d  %6s  %6s %6.1f  %9s %6d %6.1f\n",
+      $dom->name,
+      $dom->envFrom,
+      $dom->envTo,
+      $dom->seqFrom,
+      $dom->seqTo,
+      $dom->hmmFrom,
+      $dom->hmmTo,
+      $dom->bits,
+      $dom->evalue,
+      $dom->domain,
+      defined( $dom->bias ) ? $dom->bias : "-",
+
+    );
+  }
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 parsePFAMOUT 
+
+  Title    : parsePFAMOUT
+  Usage    : $self->parsePFAMOUT($filename)
+  Function : Reads in a PFAMOUT file.  This file contains the minimal amount of information
+           : require to constrcut a pfam ALIGN file.   
+  Args     : A filename. Normally this is filename
+  Returns  : A Bio::Pfam::HMM::HMMResults object
+  
+=cut
+
+sub parsePFAMOUT {
+  my $self     = shift;
+  my $filename = shift;
+
+  unless ($filename) {
+    confess('No filename or filehandle passed to parsePFAMOUT');
+  }
+
+  my $fh;
+  if ( ref($filename) eq 'GLOB' ) {
+    $fh = $filename;
+  }
+  else {
+    open( $fh, $filename ) or confess "Could not open $filename:[$!]\n";
+  }
+  my $hmmRes = Bio::Pfam::HMM::HMMResults->new;
+
+  while (<$fh>) {
+    /^# Domain scores/ && last;
+
+    #if (/^(\S+)\s+(.*?)\s+(\S+)\s+(\S+)\s+(\d+)\s*$/) {
+    if (/^(\S+)\s+(.*?)\s+(\S+)\s+(\S+)\s+(\d+)\s+\S+\s+(\S+)\s*$/) {
+      
+      $hmmRes->addHMMSeq(
+        Bio::Pfam::HMM::HMMSequence->new(
+          {
+            name       => $1,
+            desc       => $2,
+            bits       => $3,
+            evalue     => $4,
+            numberHits => $5,
+	    bias       => $6
+          }
+        )
+      );
+    }
+    elsif (/^#|^\s+$/) {
+      next;
+    }
+    else {
+      warn "Did not parse|$_|\n";
+    }
+  }
+  while (<$fh>) {
+
+    #if (/^(\S+)\s+(\d+)\s+(\d+)\s+(\d+)\s+(\d+)\s+(\S+)\s+(\S+)\s*$/) {
+    if (
+      /^(\S+)\s+(\d+)\s+(\d+)\s+(\d+)\s+(\d+)\s+(\d+)\s+(\d+)\s+(\S+)\s+(\S+)\s+\S+\s+(\S+)/)
+    {
+      $hmmRes->addHMMUnit(
+        Bio::Pfam::HMM::HMMUnit->new(
+          {
+            name     => $1,
+            envFrom  => $2,
+            envTo    => $3,
+            seqFrom  => $4,
+            seqTo    => $5,
+            hmmFrom  => $6,
+            hmmTo    => $7,
+            bits     => $8,
+            evalue   => $9,
+	    bias     => $10
+          }
+        )
+      );
+    }
+    elsif (/^#|^\s+$/) {
+      next;
+    }
+    elsif (/^$/) {
+      next;
+    }
+    else {
+      warn "Did not parse: |$_|";
+    }
+  }
+  close($fh);
+  return ($hmmRes);
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _readHeader 
+
+  Title    : _readHeader
+  Usage    : Private method.  $self->_readHeader(\*FH, $hmmResults)
+  Function : Reads the header section from a HMMER3 hmmsearch   
+  Args     : The file handle to hmmsearch output, a Bio::Pfam::HMM::HMMResults object
+  Returns  : Nothing
+  
+=cut
+
+#Parse the header part of the output first;
+sub _readHeader {
+  my ( $self, $hs, $hmmRes ) = @_;
+
+  #Check the $hs is defined and a GLOB
+
+  while (<$hs>) {
+    if (/^Scores for complete/) {
+      last;
+    }
+    elsif (/^# query HMM file:\s+(\S+)/) {
+      $hmmRes->hmmName($1);
+    }
+    elsif (/^# target sequence database:\s+(\S+)/) {
+      $hmmRes->seqDB($1);
+    }
+    elsif (/^output directed to file:\s+(\S+)/) {
+      $hmmRes->thisFile($1);
+    }
+    elsif (/^Query:\s+(\S+)\s+\[M\=(\d+)\]/) {
+      $hmmRes->seedName($1);
+      $hmmRes->hmmLength($2);
+    }elsif(/^Query:\s+(\S+)\s+\[L\=(\d+)\]/) {
+	$hmmRes->seqName($1); 
+      $hmmRes->seqLength($2);
+    }elsif (/^sequence E-value threshold: <= (\d+)/) {
+      $hmmRes->evalueThr($1);
+    }
+    elsif (/^# Random generator seed:      (\d+)/) {
+      $hmmRes->randSeedNum($1);
+    }elsif(/^Description:\s+(.*)/){
+      $hmmRes->description($1);  
+    }elsif(/^# (phmmer|hmmsearch|hmmscan|jackhmmer)/){
+      $hmmRes->program($1);
+    }elsif (/(^#)|(^$)/) {
+      next;
+    }elsif(/^Accession/){
+      next; 
+    } elsif(/^\[ok\]/) {
+      return(1);
+    } else {
+      die "Failed to parse hmmsearch results |$_| in header section\n";
+    }
+  }
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _readSeqHits 
+
+  Title    : _readSeqHits
+  Usage    : Private method.  $self->_readSeqHits(\*FH, $hmmResults)
+  Function : Reads the sequence hits from a HMMER3 hmmsearch   
+  Args     : The file handle to hmmsearch output, a Bio::Pfam::HMM::HMMResults object
+  Returns  : Nothing
+  
+=cut
+
+sub _readSeqHits {
+  my ( $self, $hs, $hmmRes ) = @_;
+  while (<$hs>) {
+
+#Match a line like this
+# E-value  score  bias    E-value  score  bias    exp  N  Sequence Description
+#    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
+#      4e-83  285.8  10.0    5.3e-83  285.5   7.0    1.1  1  Q14SN3.1 Q14SN3_9HEPC Polyprotein (Fragment).
+    if (/^Domain annotation for each [sequence|model]/) { # This is the format for HMMER3b3
+      last;
+    }
+    elsif (/^Domain and alignment annotation for each [sequence|model]/) {  #This is the format for HMMER3b2 - can be removed later
+	last;
+    }
+    elsif (/^\s+(E-value|---)/) {
+      next;
+    }
+    elsif (/^$/) {
+      next;
+    }
+    else {
+      next if(/No hits detected that satisfy reporting thresholds/);
+
+      #Assume that we have a sequence match
+      my @sMatch = split( /\s+/, $_ );
+      unless ( scalar(@sMatch) >= 10 ) {
+        die "Expected at least 10 pieces of data: $_;\n";
+      }
+      my $desc;
+      if ( scalar(@sMatch) >= 11 ) {
+        $desc = join( " ", @sMatch[ 10 .. $#sMatch ] );
+      }
+
+      $hmmRes->addHMMSeq(
+        Bio::Pfam::HMM::HMMSequence->new(
+          {
+            evalue     => $sMatch[1],
+            bits       => $sMatch[2],
+            bias       => $sMatch[3],
+            exp        => $sMatch[7],
+            numberHits => $sMatch[8],
+            name       => $sMatch[9],
+            desc       => defined($desc) ? $desc : "-",
+          }
+        )
+      );
+      
+      next;
+    }
+    die "Failed to parse $_ in sequence section\n";
+  }
+
+}
+
+#------------------------------------------------------------------------------
+
+=head2 _readUnitHits 
+
+  Title    : _readUnitHits
+  Usage    : Private method.  $self->_readUnitHits(\*FH, $hmmResults)
+  Function : Reads the unit (domain) hits from a HMMER3 hmmsearch   
+  Args     : The file handle to hmmsearch output, a Bio::Pfam::HMM::HMMResults object
+  Returns  : Nothing
+  
+=cut
+
+no warnings 'recursion';
+
+sub _readUnitHits {
+  my ( $self, $hs, $hmmRes ) = @_;
+  
+  if($hmmRes->eof){
+    return; 
+  }
+
+#Parse the domain hits section
+#>> P37935.1  MAAY4_SCHCO Mating-type protein A-alpha Y4.
+#     # bit score    bias    E-value ind Evalue hmm from   hmm to    ali from   ali to    env from   env to    ali-acc
+#   --- --------- ------- ---------- ---------- -------- --------    -------- --------    -------- --------    -------
+#     1     244.0     0.5    9.5e-76    1.7e-70        1      146 [.        1      145 [.        1      146 [.    0.99
+#
+#  Alignments for each domain:
+#  == domain 1    score: 244.0 bits;  conditional E-value: 9.5e-76
+#      SEED   1 medrlallkaisasakdlvalaasrGaksipspvkttavkfdplptPdldalrtrlkeaklPakaiksalsayekaCarWrsdleeafdktaksvsPanlhllealrirlyteqvekWlvqvlevaerWkaemekqrahiaatmgp 146
+#               m+++la+l++isa+akd++ala+srGa+++ +p++tt+++fd+l++P+ld++rtrl+ea+lP+kaik++lsaye+aCarW++dleeafd+ta+s+sP+n+++l++lr+rly+eqv+kWl++vl+v+erWkaemekqrahi+atmgp
+#  P37935.1   1 MAELLACLQSISAHAKDMMALARSRGATGS-RPTPTTLPHFDELLPPNLDFVRTRLQEARLPPKAIKGTLSAYESACARWKHDLEEAFDRTAHSISPHNFQRLAQLRTRLYVEQVQKWLYEVLQVPERWKAEMEKQRAHINATMGP 145
+#               899***************************.******************************************************************************************************************8 PP
+
+  while (<$hs>) {
+    if (/^Internal/) {
+      last;
+    }
+    elsif (/\>\>\s+(\S+)/) {
+      my $seqId = $1;    
+      $self->_readUnitData( $seqId, $hs, $hmmRes );
+      if($hmmRes->eof){
+        return; 
+      }
+    }
+  }
+}
+
+sub _readUnitData {
+  my ( $self, $id, $hs, $hmmRes ) = @_;
+  
+  if($hmmRes->eof){
+    return; 
+  }
+  my $hmmName = $hmmRes->seedName();
+
+  my $seqName = $hmmRes->seqName;
+
+# bit score    bias    E-value ind Evalue hmm from   hmm to    ali from   ali to    env from   env to    ali-acc
+#   --- --------- ------- ---------- ---------- -------- --------    -------- --------    -------- --------    -------
+#     1     244.0     0.5    9.5e-76    1.7e-70        1      146 [.        1      145 [.        1      146 [.    0.99
+#
+#  Alignments for each domain:
+
+  my @units;
+  my $align   = 1;
+  my $recurse = 0;
+  my $eof = 0;
+  my ($nextSeqId);
+  while (<$hs>) {
+    if (/^[(\/\/|Internal)]/ ) {
+      $align   = 0;
+      $recurse = 0;
+      $eof = 1;
+      last;
+    }
+    elsif (/^\>\>\s+(\S+)/) {
+      $nextSeqId = $1;
+      $align     = 0;
+      $recurse   = 1;
+      last;
+    }
+    elsif (/^\s+Alignments for each domain:/) {
+      $align   = 1;
+      $recurse = 0;
+      last;
+    }
+    elsif (/^\s+(#\s+score|---)/){
+
+      #Two human readable lines
+      next;
+    }
+    elsif (/^$/) {
+
+      #blank line
+      next;
+    }
+    elsif (/^\s+\d+\s+/) {
+      my @dMatch = split( /\s+/, $_ );
+      unless ( scalar(@dMatch) == 17 ) {
+        die "Expected 16 elements of data: $_\n";
+      }
+
+      push(
+        @units,
+        Bio::Pfam::HMM::HMMUnit->new(
+          {
+            name      => $id,
+            domain    => $dMatch[1],
+            bits      => $dMatch[3],
+            bias      => $dMatch[4],
+            domEvalue => $dMatch[5],
+            evalue    => $dMatch[6],
+            hmmFrom   => $dMatch[7],
+            hmmTo     => $dMatch[8],
+            seqFrom   => $dMatch[10],
+            seqTo     => $dMatch[11],
+            envFrom   => $dMatch[13],
+            envTo     => $dMatch[14],
+            aliAcc    => $dMatch[16]
+          }
+        )
+      );
+      
+      next;
+    }
+    elsif(/^\s+\[No individual domains/) {
+	$align=0;
+	next;
+    }
+    else {
+      confess("Did not parse line: $_");
+    }
+  }
+
+#  == domain 1    score: 244.0 bits;  conditional E-value: 9.5e-76
+#      SEED   1 medrlallkaisasakdlvalaasrGaksipspvkttavkfdplptPdldalrtrlkeaklPakaiksalsayekaCarWrsdleeafdktaksvsPanlhllealrirlyteqvekWlvqvlevaerWkaemekqrahiaatmgp 146
+#               m+++la+l++isa+akd++ala+srGa+++ +p++tt+++fd+l++P+ld++rtrl+ea+lP+kaik++lsaye+aCarW++dleeafd+ta+s+sP+n+++l++lr+rly+eqv+kWl++vl+v+erWkaemekqrahi+atmgp
+#  P37935.1   1 MAELLACLQSISAHAKDMMALARSRGATGS-RPTPTTLPHFDELLPPNLDFVRTRLQEARLPPKAIKGTLSAYESACARWKHDLEEAFDRTAHSISPHNFQRLAQLRTRLYVEQVQKWLYEVLQVPERWKAEMEKQRAHINATMGP 145
+#               899***************************.******************************************************************************************************************8 PP
+#
+# OR....
+#
+#  == domain 1    score: 27.6 bits;  conditional E-value: 7.4e-10
+#   PF00018  17 LsfkkGdvitvleksee.eWwkaelkdg.keGlvPsnYvep 55 
+#               L++++Gd+++++++++e++Ww++++++++++G++P+n+v+p
+#  P15498.4 617 LRLNPGDIVELTKAEAEqNWWEGRNTSTnEIGWFPCNRVKP 657
+#               7899**********9999*******************9987 PP
+
+
+  if ($align) {
+    my ($pattern1, $pattern2);
+
+    if($hmmName and $hmmRes->program eq 'hmmsearch'){
+      $pattern1 = qr/^\s+$hmmName\s+\d+\s+(\S+)\s+\d+/;
+      $id =~ s/(\W)/\\$1/g; # escape any non-word character
+      # $id =~ s/\|/\\|/g;  #Escape '|', '[' and ']' characters
+      # $id =~ s/\[/\\[/g;
+      # $id =~ s/\]/\\]/g;
+      $pattern2 = qr/^\s+$id\s+\d+\s+(\S+)\s+\d+/;
+    }elsif($seqName and $hmmRes->program eq 'hmmscan'){
+      my $tmpSeqName = $seqName;
+      $tmpSeqName =~ s/(\W)/\\$1/g; # escape any non-word character
+      # $tmpSeqName =~ s/\|/\\|/g; #Escape '|', '[' and ']' characters
+      # $tmpSeqName =~ s/\[/\\[/g;  
+      # $tmpSeqName =~ s/\]/\\]/g;
+      $pattern1 = qr/^\s+$id\s+\d+\s+(\S+)\s+\d+/;
+      $pattern2 = qr/^\s+$tmpSeqName\s+\d+\s+(\S+)\s+\d+/;
+    }elsif($seqName and ($hmmRes->program eq 'phmmer' or $hmmRes->program eq 'jackhmmer') ){
+      $seqName =~ s/(\W)/\\$1/g; # escape any non-word character
+      # $seqName =~ s/\|/\|/g; #Escape '|', '[' and ']' characters
+      # $seqName =~ s/\[/\\[/g;
+      # $seqName =~ s/\]/\\]/g;
+      $pattern1 = qr/^\s+$seqName\s+\d+\s+(\S+)\s+\d+/;
+      $pattern2 = qr/^\s+$id\s+\d+\s+(\S+)\s+\d+/;
+    }
+  
+
+    $recurse = 0;
+    my $matchNo;
+    my $hmmlen = 0;
+    while (<$hs>) {
+      if (/$pattern1/) {
+        $units[ $matchNo - 1 ]->hmmalign->{hmm} .= $1;
+        $hmmlen = length($1);
+      }
+      elsif (/$pattern2/) {
+        $units[ $matchNo - 1 ]->hmmalign->{seq} .= $1;
+      }
+      elsif (/^\s+([x\.]+)\s+RF$/) {
+        my $rf = $1;
+        $units[ $matchNo - 1 ]->hmmalign->{rf} .= $rf;
+      }
+      elsif (/^\s+([0-9\*\.]+)\s+PP$/) {
+        my $pp = $1;
+        $units[ $matchNo - 1 ]->hmmalign->{pp} .= $pp;
+      }elsif (/^\s+(\S+)\s+CS$/) {
+        my $cs = $1;
+        $units[ $matchNo - 1 ]->hmmalign->{cs} .= $cs;
+      }elsif (/^\s+==\s+domain\s+(\d+)/) {
+        $matchNo = $1;
+      }
+      elsif (/^\s+(.*)\s+$/) {
+      	# $1 is *not* the match - this fails if there are prepended
+      	# or appended spaces
+        # $units[ $matchNo - 1 ]->hmmalign->{match} .= $1;
+        # Let's get a right substring based on the HMM length
+        chomp;
+        my $m1 = substr($_,-$hmmlen);
+        $units[ $matchNo - 1 ]->hmmalign->{match} .= $m1;
+      }elsif (/^$/) {
+        next;
+      }
+      elsif (/^[(\/\/|Internal)]/) {
+        $align   = 0;
+        $recurse = 0;
+        $eof = 1;
+        last;
+      }
+      elsif (/^\>\>\s+(\S+)/) {
+        $nextSeqId = $1;
+        $recurse   = 1;
+        last;
+      }
+     
+      else {
+        confess("Did not parse |$_| in units");
+      }
+    }
+  }
+
+  foreach my $u (@units) {
+    $hmmRes->addHMMUnit($u);
+  }
+      
+  $hmmRes->eof($eof);
+
+  if ($recurse and $nextSeqId) {
+    $self->_readUnitData( $nextSeqId, $hs, $hmmRes );
+  }
+  return;
+}
+use warnings 'recursion';
+
+#-------------------------------------------------------------------------------
+
+=head2 parseHMMER2 
+
+  Title    : parseHMMER2
+  Usage    : $self->parseHMMER2(\*FH )
+  Function : This is a minimal parser for reading in the output of HMMER2 hmmsearch   
+  Args     : The file handle to hmmsearch output
+  Returns  : A Bio::Pfam::HMM::HMMResults object
+  
+=cut
+
+sub parseHMMER2 {
+  my $self = shift;
+  my $file = shift;
+
+  my $hmmRes = Bio::Pfam::HMM::HMMResults->new;
+
+  my %seqh;
+  my $count = 0;
+
+  while (<$file>) {
+    /^Scores for complete sequences/ && last;
+  }
+
+  while (<$file>) {
+    /^Parsed for domains/ && last;
+    if ( my ( $id, $de, $sc, $ev, $hits ) =
+      /^(\S+)\s+(.*?)\s+(\S+)\s+(\S+)\s+(\d+)\s*$/ )
+    {
+      $hmmRes->addHMMSeq(
+        Bio::Pfam::HMM::HMMSequence->new(
+          {
+            bits       => $sc,
+            evalue     => $ev,
+            name       => $id,
+            desc       => $de,
+            numberHits => $hits
+          }
+        )
+      );
+
+      $seqh{$id} = $sc;
+    }
+  }
+
+  while (<$file>) {
+    /^Histogram of all scores/ && last;
+    if ( my ( $id, $sqfrom, $sqto, $hmmf, $hmmt, $sc, $ev ) =
+      /^(\S+)\s+\S+\s+(\d+)\s+(\d+).+?(\d+)\s+(\d+)\s+\S+\s+(\S+)\s+(\S+)\s*$/ )
+    {
+      $hmmRes->addHMMUnit(
+        Bio::Pfam::HMM::HMMUnit->new(
+          {
+            name    => $id,
+            seqFrom => $sqfrom,
+            seqTo   => $sqto,
+            hmmFrom => $hmmf,
+            hmmTo   => $hmmt,
+            bits    => $sc,
+            evalue  => $ev
+          }
+        )
+      );
+
+    }
+  }
+
+  return $hmmRes;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 parseHMMER1
+
+  Title    : parseHMMER1
+  Usage    : $self->parseHMMER1(\*FH )
+  Function : This is a minimal parser for reading in the output of HMMER1 hmmsearch.
+           : There are a few hacks to get round some of them requirements     
+  Args     : The file handle to hmmsearch output
+  Returns  : A Bio::Pfam::HMM::HMMResults object
+  
+=cut
+
+sub parseHMMER1 {
+  my $self = shift;
+  my $file = shift;
+
+  my $hmmRes = Bio::Pfam::HMM::HMMResults->new;
+
+  my %seqh;
+  my $count = 0;
+
+  while (<$file>) {
+    if ( my ( $bits, $s, $e, $id, $de ) =
+/^(-?\d+\.?\d*)\s+\(bits\)\s+f:\s+(\d+)\s+t:\s+(\d+)\s+Target:\s+(\S+)\s+(.*)/
+      )
+    {
+      if ( $id =~ /(\S+)\/(\d+)-(\d+)/ ) {
+        $id = $1;
+        $s  = $2 + $s - 1;
+        $e  = $2 + $e - 1;
+      }
+
+      if ( !$hmmRes->seqs->{$id} ) {
+        $hmmRes->addHMMSeq(
+          Bio::Pfam::HMM::HMMSequence->new(
+            {
+              bits       => $bits,
+              evalue     => 1,
+              name       => $id,
+              desc       => $de,
+              numberHits => 1
+            }
+          )
+        );
+      }
+      $hmmRes->addHMMUnit(
+        Bio::Pfam::HMM::HMMUnit->new(
+          {
+            name    => $id,
+            seqFrom => $s,
+            seqTo   => $e,
+            hmmFrom => "1",
+            hmmTo   => "1",
+            bits    => $bits,
+            evalue  => "1"
+          }
+        )
+      );
+      if ( $bits > $hmmRes->seqs->{$id}->bits ) {
+        $hmmRes->seqs->{$id}->bits($bits);
+      }
+    }
+  }
+  return $hmmRes;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 writeScoresFile
+
+  Title    : writeScoresFile
+  Usage    : $hmmResIO->writeScoresFile( $hmmRes)
+  Function : Writes a scores file for a Bio::Pfam::HMM::HMMResults object.
+  Args     : Bio::Pfam::HMM::HMMResults
+  Returns  : Nothing
+  
+=cut
+
+sub writeScoresFile {
+  my ( $self, $hmmRes ) = @_;
+
+  unless ($hmmRes) {
+    confess "A Bio::Pfam::HMM::HMMResults object was not parsed in\n";
+  }
+  unless ( $hmmRes->isa("Bio::Pfam::HMM::HMMResults") ) {
+    confess("Variable passed in is not a Bio::Pfam::HMM::Results object");
+  }
+
+  my $fh;
+  open( $fh, ">" . $self->scores )
+    or confess "Could not open " . $self->scores . ":[$!]\n";
+
+  my ( $lowSeq, $lowDom, $highSeq, $highDom );
+  $lowSeq  = $lowDom  =  999999.99;
+  $highSeq = $highDom = -999999.99;
+  unless ( defined $hmmRes->domThr and defined $hmmRes->seqThr ) {
+    warn "No threshold set, setting to 25.0 bits\n";
+    $hmmRes->domThr("25.0");
+    $hmmRes->seqThr("25.0");
+  }
+
+  my @sigUnits;
+
+  foreach my $seqId ( keys %{ $hmmRes->seqs } ) {
+
+    #Does this sequence score above or equal to the sequence threshold?
+    if ( $hmmRes->seqs->{$seqId}->bits >= $hmmRes->seqThr ) {
+
+      #Is this the lowest sequence thresh
+      if ( $hmmRes->seqs->{$seqId}->bits < $lowSeq ) {
+        $lowSeq = $hmmRes->seqs->{$seqId}->bits;
+      }
+
+#For each of the regions found on the sequence, look to see if the match is great
+#than the domain threshold.  If it is, is it lower than we we have seen previously
+      foreach my $unit ( @{ $hmmRes->seqs->{$seqId}->hmmUnits } ) {
+        if ( $unit->bits >= $hmmRes->domThr ) {
+          push( @sigUnits, $unit );
+          if ( $unit->bits < $lowDom ) {
+            $lowDom = $unit->bits();
+          }
+        }
+        elsif ( $unit->bits > $highDom ) {
+          $highDom = $unit->bits;
+        }
+      }
+    }
+    else {
+
+      #Is this the highest sequence thres below the cut-off
+      if ( $hmmRes->seqs->{$seqId}->bits > $highSeq ) {
+        $highSeq = $hmmRes->seqs->{$seqId}->bits;
+      }
+
+#For each of the regions found on the sequence, look to see if the match is great
+#than the domain threshold.  If it is, is it lower than we we have seen previously
+      foreach my $unit ( @{ $hmmRes->seqs->{$seqId}->hmmUnits } ) {
+        if ( $unit->bits < $hmmRes->domThr && $unit->bits > $highDom ) {
+          $highDom = $unit->bits;
+        }
+      }
+    }
+  }
+
+  $hmmRes->domTC($lowDom);
+  $hmmRes->seqTC($lowSeq);
+  $hmmRes->domNC($highDom);
+  $hmmRes->seqNC($highSeq);
+
+  #Print the domains to the scores file
+  foreach my $u ( sort { $b->bits <=> $a->bits } @sigUnits ) {
+    print $fh
+      sprintf( "%.1f %s/%s-%s %s-%s %s\n", $u->bits, $u->name, $u->envFrom, $u->envTo, $u->seqFrom, $u->seqTo, $u->evalue );
+  }
+  close($fh);
+
+}
+
+#-------------------------------------------------------------------------------
+
+#TODO - write _readAlign
+
+=head2 _readAlign
+
+  Title    :
+  Usage    :  
+  Function :
+  Args     :
+  Returns  :
+  
+=cut
+
+sub _readAlign {
+  my ( $self, $fh, $hmmRes ) = @_;
+
+}
+
+#Parse the alignment section
+#if($pp){
+
+#}else{
+#  while(<HS>){
+#    last if(/^\/\//)
+#  }
+#}
+
+
+
+sub _readFooter {
+  my($self, $fh, $hmmRes ) = @_;
+ 
+  # We are going to parse something like this! 
+    
+  #  Internal pipeline statistics summary:
+#-------------------------------------
+#Query sequence(s):                         1  (360 residues)
+#Target model(s):                           7  (836 nodes)
+#Passed MSV filter:                         2  (0.285714); expected 0.1 (0.02)
+#Passed Vit filter:                         1  (0.142857); expected 0.0 (0.001)
+#Passed Fwd filter:                         1  (0.142857); expected 0.0 (1e-05)
+#Initial search space (Z):                  7  [actual number of targets]
+#Domain search space  (domZ):               1  [number of targets reported over threshold]
+## CPU time: 0.00u 0.00s 00:00:00.00 Elapsed: 00:00:00
+## Mc/sec: inf
+#//  
+
+  while(<$fh>){
+    if(/\/\//){
+      last;
+    }
+  }
+}
+
+
+#Parse the internal summary section
+#Internal statistics summary:
+#----------------------------
+#Query HMM(s):      1  (0 nodes)
+#Target sequences:  5323441  (0 residues)
+#Passed MSV filter: 116519  (-37389918065567040729448769671768824784852036328367855636063687997915136.000; expected 19991592792512146725679052970637918208.000)
+#Passed Vit filter: 7579  (-0.0000; expected -35982214160587876085407389642471051723332987952235753317595472501307733302049608744822636544.0000)
+#Passed Fwd filter: 1687  (8.3e+165; expected -7.5e-266)
+#Mc/sec:            828.85
+# CPU time: 115.36u 4.45s 00:01:59.81 Elapsed: 00:03:01
+
+#sub writeHMMSearch {
+#  my ( $self, $hmmRes ) = @_;
+#  my $fh;
+#  open($fh, ">".$self->outfile."\n");
+#
+#  $self->_writeHeader($fh, $hmmRes);
+#  $self->_writeSeqHits( $fh, $hmmRes);
+#  $self->_writeDomHits( $fh, $hmmRes);
+#  $self->_writeAlign( $fh, $hmmRes) if($self->align);
+#  $self->_writeInternalSummary( $fh, $hmmRes);
+#}
+#sub mergeHMMSearch {
+#  my ( $self, $filenames ) = @_;
+#}
+
+
+sub write_ascii_out {
+
+    my ($self, $HMMResults, $fh, $scanData, $e_seq, $e_dom, $b_seq, $b_dom) = @_;
+
+
+    $scanData->{_max_seqname} = 20 unless($scanData->{_max_seqname} or $scanData->{_max_seqname} < 1);
+    
+    my $ga;
+
+    if($e_seq or $e_dom) {
+	$e_seq = $e_dom unless($e_seq);
+	$e_dom = "10" unless($e_dom);
+    } 
+    elsif($b_seq or $b_dom) {
+	$b_seq = $b_dom unless($b_seq);
+	$b_dom = "0" unless($b_dom);
+    }
+    else {
+	$ga = 1;
+    }
+
+
+    foreach my $unit ( sort { $a->seqFrom <=> $b->seqFrom } @{ $HMMResults->units } ) {    
+
+        if($unit->name =~ /Pfam\-B/) {
+
+	    next unless($HMMResults->seqs->{$unit->name}->evalue <= "0.001" and $unit->evalue <= "0.001");
+
+
+	    printf $fh "%-".$scanData->{_max_seqname}."s %6d %6d %6d %6d %-11s %-16s %7s %5d %5d %5d %8s %9s %3s %-8s\n",
+	    $HMMResults->seqName,
+	    $unit->seqFrom,
+	    $unit->seqTo,
+	    $unit->envFrom,
+	    $unit->envTo,
+	    $scanData->{_accmap}->{ $unit->name },
+	    $unit->name,
+	    "Pfam-B",
+	    $unit->hmmFrom,
+	    $unit->hmmTo,
+	    $scanData->{_model_len}->{ $unit->name },
+	    $unit->bits,
+	    $unit->evalue,
+	    "NA",
+	    "NA";
+
+
+	}
+	else {
+
+            #Filter results based on thresholds
+	    if($ga) {
+		next unless($unit->sig);
+	    }
+	    if($e_seq) {
+		next unless($HMMResults->seqs->{$unit->name}->evalue <= $e_seq and $unit->evalue <= $e_dom);
+	    }
+	    if($b_seq) {
+		
+		next unless($HMMResults->seqs->{$unit->name}->bits >= $b_seq and $unit->bits >= $b_dom);
+	    }
+	    
+	    my $clan = $scanData->{_clanmap}->{ $unit->name } || "No_clan";
+	    
+	    
+	    printf $fh "%-".$scanData->{_max_seqname}."s %6d %6d %6d %6d %-11s %-16s %7s %5d %5d %5d %8s %9s %3d %-8s ",
+	    $HMMResults->seqName,
+	    $unit->seqFrom,
+	    $unit->seqTo,
+	    $unit->envFrom,
+	    $unit->envTo,
+	    $scanData->{_accmap}->{ $unit->name },
+	    $unit->name,
+	    $scanData->{_type}->{ $unit->name },
+	    $unit->hmmFrom,
+	    $unit->hmmTo,
+	    $scanData->{_model_len}->{ $unit->name },
+	    $unit->bits,
+	    $unit->evalue,
+	    $unit->sig, 
+	    $clan;
+	
+	    
+	    if($unit->{'act_site'}) {
+		local $" = ",";
+		print $fh "predicted_active_site[@{$unit->{'act_site'}}]";
+	    }
+	
+	    if($scanData->{_translate}){
+	      my $strand = '?';
+	      my $start = '-';
+	      my $end   = '-';
+	      if(exists($scanData->{_orf}->{$HMMResults->seqName})){
+	       $strand = $scanData->{_orf}->{$HMMResults->seqName}->{strand};  
+	       if($strand eq '+'){
+	         $start = $scanData->{_orf}->{$HMMResults->seqName}->{start} + ($unit->envFrom * 3) - 3;
+	         $end = $scanData->{_orf}->{$HMMResults->seqName}->{start} + ($unit->envTo * 3) - 3;
+	       }elsif($strand eq '-'){
+	         $start = $scanData->{_orf}->{$HMMResults->seqName}->{start} - ($unit->envFrom * 3) + 3;
+           $end = $scanData->{_orf}->{$HMMResults->seqName}->{start} - ($unit->envTo * 3) + 3;
+	       }
+	      }
+	      print $fh "$strand $start $end";
+	    }
+	
+	    print $fh "\n";
+	}
+
+	if($scanData->{_align}){
+	    print $fh sprintf( "%-10s %s\n", "#HMM",   $unit->hmmalign->{hmm} );
+	    print $fh sprintf( "%-10s %s\n", "#MATCH", $unit->hmmalign->{match} );
+	    print $fh sprintf( "%-10s %s\n", "#PP",   $unit->hmmalign->{pp});
+	    print $fh sprintf( "%-10s %s\n", "#SEQ",   $unit->hmmalign->{seq});
+	    print $fh sprintf( "%-10s %s\n", "#CS",   $unit->hmmalign->{cs}) if($unit->hmmalign->{cs});
+	}
+	
+    }
+    
+}
+
+1;
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMMSequence.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMMSequence.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,102 @@
+
+package Bio::Pfam::HMM::HMMSequence;
+
+use strict;
+use warnings;
+
+use Moose;
+use Moose::Util::TypeConstraints;
+
+extends 'Bio::Pfam::HMM::HMMMatch';
+
+
+has sumEvalue => (
+  isa      => 'evalue',
+  is       => 'rw',
+);
+
+
+has H2mode => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has sumScore => (
+  isa      => 'Num',
+  is       => 'rw',
+);
+
+has desc => (
+  isa      => 'Str',
+  is       => 'rw',
+  required => 1
+);
+
+has numberHits => (
+  isa      => 'Int',
+  is       => 'rw',
+  required => 1
+);
+
+
+
+has 'exp' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+
+has hmmUnits => (
+  isa => "ArrayRef[ Bio::Pfam::HMM::HMMUnit ]",
+  is  => 'rw',
+  default => sub { [] }
+);
+
+
+#-------------------------------------------------------------------------------
+=head1 Subroutines
+
+=head2 addHMMUnit 
+
+  Title    : addHMMUnit
+  Usage    : $hmmseq->addHMMUnit($hmmUnit) 
+  Function : Adds a hmmUnit to a sequence. It checks that the variable passed in is a Bio::Pfam::HMM::HMMUnit oject
+  Args     : A Bio::Pfam::HMM::HMMUnit oject
+  Returns  : Nothing
+  
+=cut
+
+sub addHMMUnit {
+  my ( $self, $hmmUnit ) = @_;
+  if($hmmUnit->isa("Bio::Pfam::HMM::HMMUnit")){
+    push(@{$self->hmmUnits}, $hmmUnit);
+  }else{
+    warn "$hmmUnit is not a Bio::Pfam::HMM::HMMUnit, not added\n"; 
+  }
+}
+
+
+  __PACKAGE__->meta->make_immutable;
+
+=head1 COPYRIGHT
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+This is free software; you can redistribute it and/or modify it under
+the terms of the GNU General Public License as published by the Free Software
+Foundation; either version 2 of the License, or (at your option) any later
+version.
+
+This program is distributed in the hope that it will be useful, but WITHOUT
+ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+details.
+
+You should have received a copy of the GNU General Public License along with
+this program. If not, see <http://www.gnu.org/licenses/>.
+
+=cut
+
+1;
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/HMM/HMMUnit.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/HMM/HMMUnit.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,138 @@
+
+package Bio::Pfam::HMM::HMMUnit;
+
+use strict;
+use warnings;
+
+use Moose;
+use Moose::Util::TypeConstraints;
+
+extends 'Bio::Pfam::HMM::HMMMatch';
+
+subtype 'Domain'
+    => as 'Int'
+    => where { $_ > 0 };
+              
+#coerce 'Domain'
+#  => from 'Str'
+#    => via {
+#      my $d;
+#      if(/(\d+)\/\d+/){
+#        $d = $1;
+#      }
+#      return $d;
+#    };
+#    
+  
+#subtype 'proteinCoos'
+#  => as 'Int'
+#  => where { $_ > 0 && $_ < 100000 }
+#  => message { 'Protein coordinates are expected to be positive and less the 100,000'};
+
+
+has 'seqEvalue' => (
+  isa      => 'Num',
+  is       => 'rw',
+);
+
+has 'domain' => (
+  isa     => 'Domain',
+  is       => 'rw'
+);
+
+has 'seqFrom' => (
+  isa => 'Int',
+  is   => 'rw',
+  required => 1
+);
+
+has 'seqTo' => (
+  isa => 'Int',
+  is  => 'rw',
+  required => 1
+);
+
+#has 'indEvalue' => (  
+#  isa => 'evalue',
+#  is  => 'rw',
+#  required => 1,
+#);
+
+has 'domEvalue' => (
+  isa => 'evalue',
+  is  => 'rw',
+);
+
+has 'hmmalign' => (
+  isa => 'HashRef',
+  is  => 'rw',
+  default => sub { {} },
+);
+
+has 'hmmFrom' => (
+  isa => 'Int',
+  is   => 'rw',
+  required => 1
+);
+
+has 'hmmTo' => (
+  isa => 'Int',
+  is  => 'rw',
+  required => 1
+);
+
+has 'envFrom' => (
+  isa => 'Int',
+  is   => 'rw'
+);
+
+has 'envTo' => (
+  isa => 'Int',
+  is  => 'rw'
+);
+
+has 'coreFrom' => (
+  isa => 'Str',
+  is   => 'rw'
+);
+
+has 'coreTo' => (
+  isa => 'Str',
+  is  => 'rw'
+);
+
+has 'aliAcc' => (
+  isa => 'Num',
+  is  => 'rw'
+);
+
+has 'sig' => (
+  isa => 'Int',
+  is  => 'rw'
+);
+
+
+__PACKAGE__->meta->make_immutable;
+
+=head1 COPYRIGHT
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+This is free software; you can redistribute it and/or modify it under
+the terms of the GNU General Public License as published by the Free Software
+Foundation; either version 2 of the License, or (at your option) any later
+version.
+
+This program is distributed in the hope that it will be useful, but WITHOUT
+ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+details.
+
+You should have received a copy of the GNU General Public License along with
+this program. If not, see <http://www.gnu.org/licenses/>.
+
+=cut
+
+1;
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/Scan/PfamScan.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/Scan/PfamScan.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,957 @@
+
+=head1 NAME
+
+Bio::Pfam::Scan::PfamScan
+
+=cut
+
+package Bio::Pfam::Scan::PfamScan;
+
+=head1 SYNOPSIS
+
+  my $ps = Bio::Pfam::Scan::PfamScan->new(
+             -cut_off => $hmmscan_cut_off,
+             -dir => $dir,
+             -clan_overlap => $clan_overlap,
+             -fasta => $fasta,
+             -align => $align,
+             -as => $as
+           );
+
+  $ps->search;
+  $ps->write_results;
+
+=head1 DESCRIPTION
+
+$Id: PfamScan.pm,v 1.4 2010-01-12 09:41:42 jm14 Exp $
+
+=cut
+
+use strict;
+use warnings;
+
+use Bio::Pfam::HMM::HMMResultsIO;
+use Bio::Pfam::Active_site::as_search;
+use Bio::SimpleAlign;
+use Bio::Pfam::Scan::Seq;
+
+use Carp;
+use IPC::Run qw( start finish );
+
+#-------------------------------------------------------------------------------
+#- constructor -----------------------------------------------------------------
+#-------------------------------------------------------------------------------
+
+=head1 METHODS
+
+=head2 new
+
+The only constructor for the object. Accepts a set of arguments that specify
+the parameters for the search:
+
+=over
+
+=item -cut_off
+
+=item -dir
+
+=item -clan_overlap
+
+=item -fasta
+
+=item -sequence
+
+=item -align
+
+=item -hmm
+
+=item -as
+
+=back
+
+=cut
+
+sub new {
+  my ( $class, @args ) = @_;
+
+  my $self = {};
+  bless $self, $class;
+
+  # To avoid hard coding the location for the binary, we assume it will be on the path.....
+  $self->{_HMMSCAN} = 'hmmscan';
+
+  # handle arguments, if we were given any here
+  $self->_process_args(@args) if @args;
+
+  return $self;
+}
+
+#-------------------------------------------------------------------------------
+#- public methods --------------------------------------------------------------
+#-------------------------------------------------------------------------------
+
+=head2 search
+
+The main method on the object. Performs a C<hmmscan> search using the supplied
+sequence and the specified HMM library.
+
+=cut
+
+sub search {
+  my ( $self, @args ) = @_;
+
+  # handle the arguments, if we were handed any here
+  $self->_process_args(@args) if @args;
+
+  # set up the output header
+  $self->_build_header;
+
+  croak qq(FATAL: no sequence given; set the search parameters before calling "search")
+    unless defined $self->{_sequence};
+
+  my ( %AllResults, $pfamB, $firstResult );
+
+  foreach my $hmmlib ( @{ $self->{_hmmlib} } ) {
+
+    my ( @hmmscan_cut_off, $seq_evalue, $dom_evalue );
+    if ( $hmmlib !~ /Pfam\-B/ ) {
+      @hmmscan_cut_off = @{ $self->{_hmmscan_cutoff} };
+    }
+    else {
+      $pfamB      = 1;
+      $seq_evalue = 0.001;
+      $dom_evalue = 0.001;
+
+      # It's a pfamB search so use some default cut off values
+      push @hmmscan_cut_off, '-E', $seq_evalue, '--domE', $dom_evalue;
+    }
+
+    push @{ $self->{_header} },
+      "#     cpu number specified: " . $self->{_cpu} . "\n"
+      if ( $hmmlib !~ /Pfam\-B/ and $self->{_cpu} );
+
+    push @{ $self->{_header} },
+      "#        searching against: "
+      . $self->{_dir}
+      . "/$hmmlib, with cut off "
+      . join( " ", @hmmscan_cut_off ) . "\n";
+    my @params;
+    if ( $self->{_cpu} ) {
+      @params = (
+        'hmmscan', '--notextw', '--cpu', $self->{_cpu}, @hmmscan_cut_off,
+        $self->{_dir} . '/' . $hmmlib,
+        $self->{_fasta}
+      );
+    }
+    else {
+      @params = (
+        'hmmscan', '--notextw', @hmmscan_cut_off, $self->{_dir} . '/' . $hmmlib,
+        $self->{_fasta}
+      );
+
+    }
+
+    print STDERR "PfamScan::search: hmmscan command: |@params|\n"
+      if $ENV{DEBUG};
+    print STDERR 'PfamScan::search: sequence: |' . $self->{_sequence} . "|\n"
+      if $ENV{DEBUG};
+
+    my $run = start \@params, '<pipe', \*IN, '>pipe', \*OUT, '2>pipe', \*ERR
+      or croak qq(FATAL: error running hmmscan; IPC::Run returned '$?');
+
+    # print IN $self->{_sequence}; ;
+    close IN;
+
+    $self->{_hmmresultIO} = Bio::Pfam::HMM::HMMResultsIO->new;
+    $self->{_all_results} = $self->{_hmmresultIO}->parseMultiHMMER3( \*OUT );
+    close OUT;
+
+    my $err;
+    while (<ERR>) {
+      $err .= $_;
+    }
+    close ERR;
+
+    finish $run
+      or croak qq|FATAL: error running hmmscan ($err); ipc returned '$?'|;
+
+    unless ( $hmmlib =~ /Pfam\-B/ ) {
+
+      if ( $self->{_clan_overlap} ) {
+        push( @{ $self->{_header} }, "#    resolve clan overlaps: off\n" );
+      }
+      else {
+        push( @{ $self->{_header} }, "#    resolve clan overlaps: on\n" );
+        $self->_resolve_clan_overlap;
+      }
+
+      if ( $self->{_as} ) {
+        push( @{ $self->{_header} }, "#     predict active sites: on\n" );
+        $self->_pred_act_sites;
+      }
+      else {
+        push( @{ $self->{_header} }, "#     predict active sites: off\n" );
+      }
+
+      if ( $self->{_translate} ) {
+        push @{ $self->{_header} },  "#   translate DNA sequence: " . $self->{_translate} . "\n";
+      }
+    }
+
+    # Determine which hits are significant
+    foreach my $result ( @{ $self->{_all_results} } ) {
+      foreach
+        my $unit ( sort { $a->seqFrom <=> $b->seqFrom } @{ $result->units } )
+      {
+
+        unless ($pfamB) {
+
+          $unit->sig(0);
+          if ( $result->seqs->{ $unit->name }->bits >=
+            $self->{_seqGA}->{ $unit->name } )
+          {
+            if ( $unit->bits >= $self->{_domGA}->{ $unit->name } ) {
+              $unit->sig(1);
+            }
+          }
+        }
+      }
+    }
+
+    if ($firstResult) {
+      $AllResults{ $self->{_all_results} } = $self->{_all_results};
+    }
+    else {
+      $firstResult = $self->{_all_results};
+    }
+
+  }    # end of "foreach $hmmlib"
+
+  # If more than one search, merge results into one object
+  if ( keys %AllResults ) {
+
+    foreach my $AllResult ( keys %AllResults ) {
+
+      foreach my $seq_id ( keys %{ $self->{_seq_hash} } ) {
+
+        my $flag;
+
+        #If seq exists in both, add all units from $AllResult to $firstResult
+        foreach my $result ( @{$firstResult} ) {
+
+          if ( $result->seqName eq $seq_id ) {
+            $flag = 1;
+
+            foreach my $result2 ( @{ $AllResults{$AllResult} } ) {
+
+              if ( $result2->seqName eq $seq_id ) {
+                foreach my $hmmname ( keys %{ $result2->seqs } ) {
+                  $result->addHMMSeq( $result2->seqs->{$hmmname} );
+                }
+                foreach my $unit ( @{ $result2->units } ) {
+                  $result->addHMMUnit($unit);
+                }
+              }
+            }
+          }
+        }
+
+        #If seq doesn't exist in $firstResult, need to add both sequence and units to $firstResult
+        unless ($flag) {
+          foreach my $result2 ( @{ $AllResults{$AllResult} } ) {
+            if ( $result2->seqName eq $seq_id ) {
+              push @{$firstResult}, $result2;
+            }
+          }
+        }
+      }
+    }
+    $self->{_all_results} = $firstResult;
+
+  }    # end of "if keys %AllResults"
+
+  push @{ $self->{_header} }, "# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =\n#\n";
+
+  if ( $self->{_as} ) {
+    push @{ $self->{_header} }, "# <seq id> <alignment start> <alignment end> <envelope start> <envelope end> <hmm acc> <hmm name> <type> <hmm start> <hmm end> <hmm length> <bit score> <E-value> <significance> <clan> <predicted_active_site_residues>";
+  }
+  else {
+    push @{ $self->{_header} }, "# <seq id> <alignment start> <alignment end> <envelope start> <envelope end> <hmm acc> <hmm name> <type> <hmm start> <hmm end> <hmm length> <bit score> <E-value> <significance> <clan>";
+  }
+
+  if ( $self->{_translate} ) {
+    push @{ $self->{_header} }, " <strand> <nt start> <nt end>";
+  }
+  push @{ $self->{_header} }, "\n";
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 write_results
+
+Writes the results of the C<hmmscan> search. Takes a single argument, which can
+be an open filehandle or a filename. A fatal error is generated if a file of the
+given name already exists.
+
+=cut
+
+sub write_results {
+  my ( $self, $out, $e_seq, $e_dom, $b_seq, $b_dom ) = @_;
+
+  my $fh;
+
+  if ( ref $out eq 'GLOB' ) {
+
+    # we were handed a filehandle
+    $fh = $out;
+  }
+  elsif ( $out and not ref $out ) {
+
+    # we were handed a filename
+    croak qq(FATAL: output file "$out" already exists) if -f $out;
+
+    open( FH, ">$out" )
+      or croak qq(FATAL: Can\'t write to your output file "$out": $!);
+    $fh = \*FH;
+  }
+  else {
+
+    # neither filehandle nor filename, default to STDOUT
+    $fh = \*STDOUT;
+  }
+
+  if ( $self->{_header} ) {
+    my $header = join '', @{ $self->{_header} };
+    print $fh "$header\n";
+  }
+
+  foreach my $result ( @{ $self->{_all_results} } ) {
+    $self->{_hmmresultIO}
+      ->write_ascii_out( $result, $fh, $self, $e_seq, $e_dom, $b_seq, $b_dom );
+  }
+  close $fh;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 results
+
+Returns the search results.
+
+=cut
+
+sub results {
+  my ( $self, $e_value ) = @_;
+
+  unless ( defined $self->{_all_results} ) {
+    carp "WARNING: call search() before trying to retrieve results";
+    return;
+  }
+
+  my @search_results = ();
+
+  foreach my $hmm_result ( @{ $self->{_all_results} } ) {
+    push @search_results, @{ $hmm_result->results( $self, $e_value ) };
+  }
+
+  return \@search_results;
+}
+
+#-------------------------------------------------------------------------------
+#- private methods -------------------------------------------------------------
+#-------------------------------------------------------------------------------
+
+=head1 PRIVATE METHODS
+
+=head2 _process_args
+
+Handles the input arguments.
+
+=cut
+
+sub _process_args {
+  my ( $self, @args ) = @_;
+
+  # accept both a hash and a hash ref
+  my $args = ( ref $args[0] eq 'HASH' ) ? shift @args : {@args};
+
+  # make sure we get a sequence
+  if ( $args->{-fasta} and $args->{-sequence} ) {
+    croak qq(FATAL: "-fasta" and "-sequence" are mutually exclusive);
+  }
+  elsif ( $args->{-fasta} ) {
+    croak qq(FATAL: fasta file "$args->{-fasta}" doesn\'t exist)
+      unless -s $args->{-fasta};
+  }
+  elsif ( $args->{-sequence} ) {
+    croak qq(FATAL: no sequence given)
+      unless length( $args->{-sequence} );
+  }
+  else {
+    croak qq(FATAL: must specify either "-fasta" or "-sequence");
+  }
+
+  # check the cut off
+  if ( ( $args->{-e_seq} and ( $args->{-b_seq} || $args->{-b_dom} ) )
+    or ( $args->{-b_seq} and ( $args->{-e_seq} || $args->{-e_dom} ) )
+    or ( $args->{-b_dom} and $args->{-e_dom} ) )
+  {
+    croak qq(FATAL: can\'t use e value and bit score threshold together);
+  }
+
+  $self->{_hmmscan_cutoff} = ();
+  if ( $args->{-e_seq} ) {
+    croak qq(FATAL: the E-value sequence cut-off "$args->{-e_seq}" must be a positive non-zero number)
+      unless $args->{-e_seq} > 0;
+
+    push @{ $self->{_hmmscan_cutoff} }, '-E', $args->{-e_seq};
+  }
+
+  if ( $args->{-e_dom} ) {
+    croak q(FATAL: if you supply "-e_dom" you must also supply "-e_seq")
+      unless $args->{-e_seq};
+
+    croak qq(FATAL: the E-value domain cut-off "$args->{-e_dom}" must be positive non-zero number)
+      unless $args->{-e_dom} > 0;
+
+    push @{ $self->{_hmmscan_cutoff} }, '--domE', $args->{-e_dom};
+  }
+
+  if ( $args->{-b_seq} ) {
+    push @{ $self->{_hmmscan_cutoff} }, '-T', $args->{-b_seq};
+  }
+
+  if ( $args->{-b_dom} ) {
+    croak q(FATAL: if you supply "-b_dom" you must also supply "-b_seq")
+      unless $args->{-b_seq};
+
+    push @{ $self->{_hmmscan_cutoff} }, '--domT', $args->{-b_dom};
+  }
+
+  unless ( $self->{_hmmscan_cutoff} ) {
+    push @{ $self->{_hmmscan_cutoff} }, '--cut_ga';
+  }
+
+  # make sure we have a valid directory for the HMM data files
+  croak qq(FATAL: directory "$args->{-dir}" does not exist)
+    unless -d $args->{-dir};
+
+  # populate the object
+  $self->{_cut_off}      = $args->{-cut_off};
+  $self->{_dir}          = $args->{-dir};
+  $self->{_clan_overlap} = $args->{-clan_overlap};
+  $self->{_fasta}        = $args->{-fasta};
+  $self->{_align}        = $args->{-align};
+  $self->{_as}           = $args->{-as};
+  $self->{_sequence}     = $args->{-sequence};
+  $self->{_cpu}          = $args->{-cpu};
+  $self->{_translate}    = $args->{-translate};
+
+  $self->{_hmmlib} = [];
+  if ( $args->{-hmmlib} ) {
+    if ( ref $args->{-hmmlib} eq 'ARRAY' ) {
+      push @{ $self->{_hmmlib} }, @{ $args->{-hmmlib} };
+    }
+    else {
+      push @{ $self->{_hmmlib} }, $args->{-hmmlib};
+    }
+  }
+  else {
+    push @{ $self->{_hmmlib} }, "Pfam-A.hmm";
+  }
+
+  # Now check that the library exists in the data dir!
+  foreach my $hmmlib ( @{ $self->{_hmmlib} } ) {
+
+    croak qq(FATAL: can't find $hmmlib and/or $hmmlib binaries in "$args->{-dir}")
+      unless (
+      -s $self->{_dir},
+      "/$hmmlib"
+      and -s $self->{_dir} . "/$hmmlib.h3f"
+      and -s $self->{_dir} . "/$hmmlib.h3i"
+      and -s $self->{_dir} . "/$hmmlib.h3m"
+      and -s $self->{_dir} . "/$hmmlib.h3p"
+      and -s $self->{_dir} . "/$hmmlib.dat"
+      );
+
+    # read the necessary data, if it's not been read already
+    $self->_read_pfam_data;
+  }
+
+  $self->{_max_seqname} = 0;
+
+  # if there's nothing in "_sequence" try to load a fasta file
+  $self->_read_fasta
+    unless $self->{_sequence};
+
+  # check again for a sequence. If we don't have one at this point, bail with
+  # an error
+  croak qq(FATAL: no sequence given)
+    unless $self->{_sequence};
+
+  # read fasta file, store maximum sequence name and store sequences for active
+  # sites prediction
+  $self->_parse_sequence
+    unless $self->{_max_seqname};
+
+  if ( $self->{_as} ) {
+    $self->_parse_act_site_data
+      unless $self->{_read_read_act_site_data};
+  }
+
+  if ( $self->{_translate} ) {
+    $self->_translate_fasta;
+  }
+
+  # see if a version number was specified
+  $self->{_version} = $args->{version};
+
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _build_header
+
+Adds version to the header object
+
+=cut
+
+sub _build_header {
+  my ( $self, $version ) = @_;
+
+  unshift @{ $self->{_header} },
+    '#      query sequence file: ' . $self->{_fasta} . "\n";
+
+  unshift @{ $self->{_header} }, <<EOF_license;
+# Copyright (c) 2009 Genome Research Ltd\n# Freely distributed under the GNU 
+# General Public License
+#
+# Authors: Jaina Mistry (jaina\@ebi.ac.uk), 
+#          Rob Finn (rdf\@ebi.ac.uk)
+#
+# This is free software; you can redistribute it and/or modify it under
+# the terms of the GNU General Public License as published by the Free Software
+# Foundation; either version 2 of the License, or (at your option) any later version.
+# This program is distributed in the hope that it will be useful, but WITHOUT
+# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+# FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+# details.
+#
+# You should have received a copy of the GNU General Public License along with
+# this program. If not, see <http://www.gnu.org/licenses/>. 
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+EOF_license
+
+  my $v =
+    ( defined $self->{_version} )
+    ? "version $version, "
+    : '';
+
+  unshift @{ $self->{_header} },
+    "# pfam_scan.pl, $v run at " . scalar(localtime) . "\n#\n";
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _read_fasta
+
+Reads a sequence from the fasta-format file that was specified in the 
+parameters.
+
+=cut
+
+sub _read_fasta {
+  my $self = shift;
+
+  open( FASTA, $self->{_fasta} )
+    or croak qq(FATAL: Couldn't open fasta file "$self->{_fasta}" $!\n);
+  my @rows = <FASTA>;
+  close FASTA;
+
+  $self->{_sequence_rows} = \@rows;
+
+  $self->{_sequence} = join '', @rows;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _resolve_clan_overlap
+
+Resolves overlaps between clans.
+
+=cut
+
+sub _resolve_clan_overlap {
+  my $self = shift;
+
+  my @no_clan_overlap = ();
+  foreach my $result ( @{ $self->{_all_results} } ) {
+    my $new =
+      $result->remove_overlaps_by_clan( $self->{_clanmap}, $self->{_nested} );
+
+    push @no_clan_overlap, $new;
+  }
+
+  $self->{_all_results} = \@no_clan_overlap;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _pred_act_sites
+
+Predicts active sites. Takes no arguments. Populates the "act_site" field on
+each results object.
+
+=cut
+
+sub _pred_act_sites {
+  my $self = shift;
+
+  # print STDERR "predicting active sites...\n";
+
+  my $hmm_file = $self->{_dir} . '/Pfam-A.hmm';
+
+RESULT: foreach my $result ( @{ $self->{_all_results} } ) {
+
+    # print STDERR "result: |" . $result->seqName . "|\n";
+
+  UNIT: foreach my $unit ( @{ $result->units } ) {
+
+      # print STDERR "family: |" . $unit->name . "|\n";
+
+      next UNIT
+        unless ( $self->{_act_site_data}->{ $unit->name }->{'alignment'} );
+
+      my $seq_region = substr(
+        $self->{_seq_hash}->{ $result->seqName },
+        $unit->seqFrom - 1,
+        $unit->seqTo - $unit->seqFrom + 1
+      );
+
+      my $seq_se = $unit->seqFrom . '-' . $unit->seqTo;
+
+      # print STDERR "seq_id:     |" . $result->seqName . "|\n";
+      # print STDERR "seq_se:     |" . $seq_se . "|\n";
+      # print STDERR "seq_region: |" . $seq_region . "|\n";
+      # print STDERR "family:     |" . $unit->name . "|\n";
+      # print STDERR "hmm_file:   |" . $hmm_file . "|\n";
+      # print STDERR "dir:        |" . $self->{_dir} . "|\n";
+
+      $unit->{act_site} = Bio::Pfam::Active_site::as_search::find_as(
+        $self->{_act_site_data}->{ $unit->name }->{'alignment'},
+        $self->{_act_site_data}->{ $unit->name }->{'residues'},
+        $result->seqName,
+        $seq_se,
+        $seq_region,
+        $unit->name,
+        $hmm_file
+      );
+    }
+  }
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _read_pfam_data
+
+Reads the Pfam data file ("Pfam-A.scan.dat") and populates the C<accmap>, 
+C<nested> and C<clanmap> hashes on the object.
+
+=cut
+
+sub _read_pfam_data {
+  my $self = shift;
+
+  #print STDERR "reading " . $self->{_hmmlib} . ".dat\n" if($ENV{DEBUG});
+  $self->{_accmap}    = {};
+  $self->{_nested}    = {};
+  $self->{_clanmap}   = {};
+  $self->{_desc}      = {};
+  $self->{_seqGA}     = {};
+  $self->{_domGA}     = {};
+  $self->{_type}      = {};
+  $self->{_model_len} = {};
+
+  foreach my $hmmlib ( @{ $self->{_hmmlib} } ) {
+    my $scandat = $self->{_dir} . '/' . $hmmlib . '.dat';
+    open( SCANDAT, $scandat )
+      or croak qq(FATAL: Couldn't open "$scandat" data file: $!);
+    my $id;
+    while (<SCANDAT>) {
+      if (m/^\#=GF ID\s+(\S+)/) {
+        $id = $1;
+      }
+      elsif (m/^\#=GF\s+AC\s+(\S+)/) {
+        $self->{_accmap}->{$id} = $1;
+      }
+      elsif (m/^\#=GF\s+DE\s+(.+)/) {
+        $self->{_desc}->{$id} = $1;
+      }
+      elsif (m/^\#=GF\s+GA\s+(\S+)\;\s+(\S+)\;/) {
+        $self->{_seqGA}->{$id} = $1;
+        $self->{_domGA}->{$id} = $2;
+      }
+      elsif (m/^\#=GF\s+TP\s+(\S+)/) {
+        $self->{_type}->{$id} = $1;
+      }
+      elsif (m/^\#=GF\s+ML\s+(\d+)/) {
+        $self->{_model_len}->{$id} = $1;
+      }
+      elsif (/^\#=GF\s+NE\s+(\S+)/) {
+        $self->{_nested}->{$id}->{$1} = 1;
+        $self->{_nested}->{$1}->{$id} = 1;
+      }
+      elsif (/^\#=GF\s+CL\s+(\S+)/) {
+        $self->{_clanmap}->{$id} = $1;
+      }
+    }
+
+    close SCANDAT;
+
+    # set a flag to show that we've read the data files already
+    $self->{ '_read_' . $hmmlib } = 1;
+  }
+
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _read_act_site_data
+
+Reads the Pfam active site data file ("active_site.dat") and populates
+the C<act_site_data> hashes on the object.
+
+=cut
+
+sub _parse_act_site_data {
+  my $self   = shift;
+  my $as_dat = $self->{_dir} . '/active_site.dat';
+
+  $self->{_act_site_data} = {};
+
+  open( AS, $as_dat )
+    or croak qq(FATAL: Couldn\'t open "$as_dat" data file: $!);
+
+  my ( $fam_id, $aln );
+
+  while (<AS>) {
+    if (/^ID\s+(\S+)/) {
+      $fam_id = $1;
+      $aln    = new Bio::SimpleAlign;
+    }
+    elsif (/^AL\s+(\S+)\/(\d+)\-(\d+)\s+(\S+)/) {
+      my ( $seq_id, $st, $en, $seq ) = ( $1, $2, $3, $4 );
+
+      $aln->add_seq(
+        Bio::Pfam::Scan::Seq->new(
+          '-seq'   => $seq,
+          '-id'    => $seq_id,
+          '-start' => $st,
+          '-end'   => $en,
+          '-type'  => 'aligned'
+        )
+      );
+    }
+    elsif (/^RE\s+(\S+)\s+(\d+)/) {
+      my ( $seq_id, $res ) = ( $1, $2 );
+      push(
+        @{ $self->{_act_site_data}->{$fam_id}->{'residues'}->{$seq_id} },
+        $res
+      );
+
+    }
+    elsif (/^\/\//) {
+
+      $self->{_act_site_data}->{$fam_id}->{'alignment'} = $aln;
+
+      $fam_id = "";
+      $aln    = "";
+
+    }
+    else {
+      warn "Ignoring line:\n[$_]";
+    }
+  }
+  close AS;
+  $self->{_read_read_act_site_data} = 1;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _parse_sequence
+
+This method is used to parse the sequence and hash it on sequence
+identifier. It also stores the length of the longest sequence id
+
+=cut
+
+sub _parse_sequence {
+  my $self = shift;
+
+  my $seq_hash = {};
+  my $seq_id;
+  foreach ( @{ $self->{_sequence_rows} } ) {
+
+    next if m/^\s*$/;    #Ignore blank lines
+
+    if (m/^>(\S+)/) {
+      $seq_id = $1;
+
+      if ( exists( $seq_hash->{$seq_id} ) ) {
+        croak "FATAL: Sequence identifiers must be unique. Your fasta file contains two sequences with the same id ($seq_id)";
+      }
+
+      #Store the max length of seq name, use this later when printing in ascii
+      $self->{_max_seqname} = length($seq_id)
+        if ( !$self->{_max_seqname}
+        or length($seq_id) > $self->{_max_seqname} );
+    }
+    else {
+      croak "FATAL: Unrecognised format of fasta file. Each sequence must have a header line in the format '>identifier  <optional description>'"
+        unless defined $seq_id;
+      chomp;
+      $seq_hash->{$seq_id} .= $_;
+    }
+  }
+
+  $self->{_seq_hash} = $seq_hash;
+}
+
+#-------------------------------------------------------------------------------
+
+=head2 _translate_fasta
+
+Uses the HMMER v2.3.2 progam "translate" to perform a six-frame translation of
+the input sequence. Checks the parameter "-translate". 
+
+Accepted arguments are "all" and "orf", where "all" means (from the "translate"
+help text) "translate in full, with stops; no individual ORFs" and "orf" means
+"report only ORFs greater than minlen" where minlen is set to the default of
+20.
+
+=cut
+
+sub _translate_fasta {
+  my ($self) = @_;
+  my $translatedFasta = $self->{_fasta} . ".translated";
+
+  my @params = ( 'translate', '-q', );
+  if ( $self->{_translate} eq 'all' ) {
+    push( @params, '-a' );
+  }
+  elsif ( $self->{_translate} eq 'orf' ) {
+    push( @params, '-l', '20' );
+  }
+  else {
+    croak qq(Unexpected parameter '$self->{_translate}');
+  }
+  push( @params, '-o', $translatedFasta, $self->{_fasta} );
+
+  print STDERR "PfamScan::translate_fasta: translate command: |@params|\n"
+    if $ENV{DEBUG};
+
+  my $run = start \@params, '<pipe', \*IN, '>pipe', \*OUT, '2>pipe', \*ERR
+    or croak qq(FATAL: error running translate; IPC::Run returned '$?');
+
+  close IN;
+  close OUT;
+
+  my $err;
+  while (<ERR>) {
+    $err .= $_;
+  }
+  close ERR;
+
+  finish $run
+    or croak qq|FATAL: error running translate ($err); ipc returned '$?'|;
+  open( F, "<", $translatedFasta )
+    or croak qw(Could not open $translatedFasta '$!');
+  if ( $self->{_translate} eq 'orf' ) {
+    while (<F>) {
+      if (/^>\s?(\S+).*nt (\d+)\.+(\d+)/) {
+        $self->{_orf}->{$1}->{start}  = $2;
+        $self->{_orf}->{$1}->{end}    = $3;
+        $self->{_orf}->{$1}->{strand} = ( $2 < $3 ) ? '+' : '-';
+      }
+    }
+  }
+  else {
+    my $currentSeq;
+    my $currentFrame;
+    my $currentLen = 0;
+    my $maxEnd = 0;
+    while (<F>) {
+      chomp;
+      if (/^>\s?(\S+\:)(\d+)/) {
+        if ( $currentLen > 0 ) {
+          my $seqName = $currentSeq . $currentFrame;
+          if ( $currentFrame < 3 ) {
+            my $start = 1 + $currentFrame;
+            my $end   = $start + $currentLen - 1;
+            $self->{_orf}->{$seqName}->{strand} = '+';
+            $self->{_orf}->{$seqName}->{start}  = $start;
+            $self->{_orf}->{$seqName}->{end}    = $end;
+            $maxEnd = $end if ( $end > $maxEnd );
+          }
+          else {
+            my $start = $maxEnd - ( $currentFrame - 3 );
+            my $end = $start - $currentLen + 1;
+            $self->{_orf}->{$seqName}->{strand} = '-';
+            $self->{_orf}->{$seqName}->{start}  = $start;
+            $self->{_orf}->{$seqName}->{end}    = $end;
+          }
+        }
+        $currentLen   = 0;
+        $currentSeq   = $1;
+        $currentFrame = $2;
+      }
+      else {
+        $currentLen += length($_) * 3;
+      }
+    }
+    my $seqName = $currentSeq . $currentFrame;
+    if ( $currentFrame < 3 ) {
+      my $start = 1 + $currentFrame;
+      my $end   = $start + $currentLen - 1;
+      $self->{_orf}->{$seqName}->{strand} = '+';
+      $self->{_orf}->{$seqName}->{start}  = $start;
+      $self->{_orf}->{$seqName}->{end}    = $end;
+      $maxEnd = $end if ( $end > $maxEnd );
+    }
+    else {
+      my $start = $maxEnd - ( $currentFrame - 3 );
+      my $end = $start - $currentLen + 1;
+      $self->{_orf}->{$seqName}->{strand} = '-';
+      $self->{_orf}->{$seqName}->{start}  = $start;
+      $self->{_orf}->{$seqName}->{end}    = $end;
+    }
+  }
+  $self->{_fasta} = $translatedFasta;
+}
+#-------------------------------------------------------------------------------
+
+=head1 COPYRIGHT
+
+Copyright (c) 2009: Genome Research Ltd.
+
+Authors: Jaina Mistry (jm14@sanger.ac.uk), John Tate (jt6@sanger.ac.uk), Rob Finn (finnr@janelia.hhmi.org)
+
+This is free software; you can redistribute it and/or
+modify it under the terms of the GNU General Public License
+as published by the Free Software Foundation; either version 2
+of the License, or (at your option) any later version.
+
+This program is distributed in the hope that it will be useful,
+but WITHOUT ANY WARRANTY; without even the implied warranty of
+MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+GNU General Public License for more details.
+
+You should have received a copy of the GNU General Public License
+along with this program; if not, write to the Free Software
+Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.
+or see the on-line version at http://www.gnu.org/copyleft/gpl.txt
+ 
+=cut
+
+  1;
+
diff -r 000000000000 -r 68a3648c7d91 pfamScan/Bio/Pfam/Scan/Seq.pm
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/Bio/Pfam/Scan/Seq.pm	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,57 @@
+package Bio::Pfam::Scan::Seq;
+
+use strict;
+use warnings;
+
+use Bio::LocatableSeq;
+use Bio::Seq::RichSeq;
+
+use base qw(Bio::LocatableSeq Bio::Seq::RichSeq);
+
+sub new {
+  my($class, %params ) = @_;
+  my( $id, $start, $end, $seq) =
+      (
+       ($params{'-ID'}          || $params{'-id'}),
+       ($params{'-START'}       || $params{'-start'}),
+       ($params{'-END'}         || $params{'-end'}),
+       ($params{'-SEQ'}         || $params{'-seq'}),
+       );
+
+  my $self = $class->SUPER::new( %params );  # this is Bio::Pfam::Root
+                      # so we have to set Bio::LocatableSeq fields ourself
+
+
+
+
+  $self->id( $id );
+  $self->start( $start );
+  $self->end( $end );
+  $self->seq( $seq );
+
+
+  return $self; # success - we hope!
+}
+
+=head1 COPYRIGHT
+
+Copyright (c) 2007: Genome Research Ltd.
+
+Authors: Rob Finn (rdf@sanger.ac.uk), John Tate (jt6@sanger.ac.uk)
+
+This is free software; you can redistribute it and/or modify it under
+the terms of the GNU General Public License as published by the Free Software
+Foundation; either version 2 of the License, or (at your option) any later
+version.
+
+This program is distributed in the hope that it will be useful, but WITHOUT
+ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+details.
+
+You should have received a copy of the GNU General Public License along with
+this program. If not, see <http://www.gnu.org/licenses/>.
+
+=cut
+
+1
diff -r 000000000000 -r 68a3648c7d91 pfamScan/htt.fas
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/htt.fas	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,42 @@
+>gi|296434520|sp|P42858.2|HD_HUMAN RecName: Full=Huntingtin; AltName: Full=Huntington disease protein; Short=HD protein
+MATLEKLMKAFESLKSFQQQQQQQQQQQQQQQQQQQQQPPPPPPPPPPPQLPQPPPQAQPLLPQPQPPPP
+PPPPPPGPAVAEEPLHRPKKELSATKKDRVNHCLTICENIVAQSVRNSPEFQKLLGIAMELFLLCSDDAE
+SDVRMVADECLNKVIKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLL
+PCLTRTSKRPEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQH
+SRRTQYFYSWLLNVLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKDTSLKGSFGVTRKEMEVSPS
+AEQLVQVYELTLHHTQHQDHNVVTGALELLQQLFRTPPPELLQTLTAVGGIGQLTAAKEESGGRSRSGSI
+VELIAGGGSSCSPVLSRKQKGKVLLGEEEALEDDSESRSDVSSSALTASVKDEISGELAASSGVSTPGSA
+GHDIITEQPRSQHTLQADSVDLASCDLTSSATDGDEEDILSHSSSQVSAVPSDPAMDLNDGTQASSPISD
+SSQTTTEGPDSAVTPSDSSEIVLDGTDNQYLGLQIGQPQDEDEEATGILPDEASEAFRNSSMALQQAHLL
+KNMSHCRQPSDSSVDKFVLRDEATEPGDQENKPCRIKGDIGQSTDDDSAPLVHCVRLLSASFLLTGGKNV
+LVPDRDVRVSVKALALSCVGAAVALHPESFFSKLYKVPLDTTEYPEEQYVSDILNYIDHGDPQVRGATAI
+LCGTLICSILSRSRFHVGDWMGTIRTLTGNTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSS
+SYSELGLQLIIDVLTLRNSSYWLVRTELLETLAEIDFRLVSFLEAKAENLHRGAHHYTGLLKLQERVLNN
+VVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQGQADPVVAVARDQSSVYLKLLMHETQPPSHFSVSTI
+TRIYRGYNLLPSITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLLSTAFPVCIWSLGWHCGVP
+PLSASDESRKSCTVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRSSWASEEEANPAAT
+KQEEVWPALGDRALVPMVEQLFSHLLKVINICAHVLDDVAPGPAIKAALPSLTNPPSLSPIRRKGKEKEP
+GEQASVPLSPKKGSEASAASRQSDTSGPVTTSKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNST
+EKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDG
+LSSNPSKSQGRAQRLGSSSVRPGLYHYCFMAPYTHFTQALADASLRNMVQAEQENDTSGWFDVLQKVSTQ
+LKTNLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQV
+FIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIP
+ALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKENEDKWKRLSRQI
+ADIILPMLAKQQMHIDSHEALGVLNTLFEILAPSSLRPVDMLLRSMFVTPNTMASVSTVQLWISGILAIL
+RVLISQSTEDIVLSRIQELSFSPYLISCTVINRLRDGDSTSTLEEHSEGKQIKNLPEETFSRFLLQLVGI
+LLEDIVTKQLKVEMSEQQHTFYCQELGTLLMCLIHIFKSGMFRRITAAATRLFRSDGCGGSFYTLDSLNL
+RARSMITTHPALVLLWCQILLLVNHTDYRWWAEVQQTPKRHSLSSTKLLSPQMSGEEEDSDLAAKLGMCN
+REIVRRGALILFCDYVCQNLHDSEHLTWLIVNHIQDLISLSHEPPVQDFISAVHRNSAASGLFIQAIQSR
+CENLSTPTMLKKTLQCLEGIHLSQSGAVLTLYVDRLLCTPFRVLARMVDILACRRVEMLLAANLQSSMAQ
+LPMEELNRIQEYLQSSGLAQRHQRLYSLLDRFRLSTMQDSLSPSPPVSSHPLDGDGHVSLETVSPDKDWY
+VHLVKSQCWTRSDSALLEGAELVNRIPAEDMNAFMMNSEFNLSLLAPCLSLGMSEISGGQKSALFEAARE
+VTLARVSGTVQQLPAVHHVFQPELPAEPAAYWSKLNDLFGDAALYQSLPTLARALAQYLVVVSKLPSHLH
+LPPEKEKDIVKFVVATLEALSWHLIHEQIPLSLDLQAGLDCCCLALQLPGLWSVVSSTEFVTHACSLIYC
+VHFILEAVAVQPGEQLLSPERRTNTPKAISEEEEEVDPNTQNPKYITAACEMVAEMVESLQSVLALGHKR
+NSGVPAFLTPLLRNIIISLARLPLVNSYTRVPPLVWKLGWSPKPGGDFGTAFPEIPVEFLQEKEVFKEFI
+YRINTLGWTSRTQFEETWATLLGVLVTQPLVMEQEESPPEEDTERTQINVLAVQAITSLVLSAMTVPVAG
+NPAVSCLEQQPRNKPLKALDTRFGRKLSIIRGIVEQEIQAMVSKRENIATHHLYQAWDPVPSLSPATTGA
+LISHEKLLLQINPERELGSMSYKLGQVSIHSVWLGNSITPLREEEWDEEEEEEADAPAPSSPPTSPVNSR
+KHRAGVDIHSCSQFLLELYSRWILPSSSARRTPAILISEVVRSLLVVSDLFTERNQFELMYVTLTELRRV
+HPSEDEILAQYLVPATCKAAAVLGMDKAVAEPVSRLLESTLRSSHLPSRVGALHGVLYVLECDLLDDTAK
+QLIPVISDYLLSNLKGIAHCVNIHSQQHVLVMCATAFYLIENYPLDVGPEFSASIIQMCGVML
diff -r 000000000000 -r 68a3648c7d91 pfamScan/pfamScan.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/pfamScan.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,32 @@
+<tool id="pfamScam" name="PFAM Annotator">
+	<description>Annotate PFAM domains. </description>
+	<command> /home/inmare/galaxy/tools/pfamScan/pfam_scan.pl -fasta $input -cpu 2 -dir /home/inmare/galaxy/tools/pfamScan/hmm > $output</command>
+	
+	<inputs>
+		<param format="fasta" name="input" type="data" label="Source file"/>
+	</inputs>
+	
+	<outputs>
+		<data format="tabular" name="output" />
+	</outputs>
+
+	<tests>
+		<test>
+			<param name="input" value="htt.fas"/>
+			<output name="out_file1" file="htt.dom.txt"/>
+		</test>
+	</tests>
+	<citations>
+		Predicting active site residue annotations in the Pfam database.
+		(2007) BMC bioinformatics 8 :298
+		PMID: 17688688
+
+		The EMBL-EBI bioinformatics web and programmatic tools framework.
+		(2015 July 01) Nucleic acids research 43 (W1) :W580-4
+		PMID: 25845596
+
+	</citations>	
+	<help>
+		The pfam_scan.pl script is used to annotate PFAM domains on the input file sequences. Only PFAM A class domains are predicted. See http://www.ebi.ac.uk/Tools/pfa/pfamscan/help/ for instructions on how to obtain pfamSCAN and for a brief description of the output format.
+	</help>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 pfamScan/pfam_scan.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfamScan/pfam_scan.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,338 @@
+#!/usr/bin/env perl
+
+# $Id: pfam_scan.pl 9045 2015-05-26 09:09:52Z rdf $
+
+use strict;
+use warnings;
+
+BEGIN {push @INC,"/home/inmare/galaxy/tools/pfamScan"}
+use Bio::Pfam::Scan::PfamScan;
+use Getopt::Long;
+
+my $VERSION = "1.5"; 
+
+#-------------------------------------------------------------------------------
+
+# get the user options
+my ( $outfile, $e_seq, $e_dom, $b_seq, $b_dom, $dir, 
+     $clan_overlap, $fasta, $align, $help, $as, $pfamB, 
+     $json, $only_pfamB, $cpu, $translate );
+GetOptions( 'help'         => \$help,
+            'outfile=s'    => \$outfile,
+            'e_seq=f'      => \$e_seq,
+            'e_dom=f'      => \$e_dom,
+            'b_seq=f'      => \$b_seq,
+            'b_dom=f'      => \$b_dom,
+            'dir=s'        => \$dir,
+            'clan_overlap' => \$clan_overlap,
+            'fasta=s'      => \$fasta,
+            'align'        => \$align,
+            'h'            => \$help,
+            'as'           => \$as,
+            'pfamB'        => \$pfamB,
+            'only_pfamB'   => \$only_pfamB,
+            'json:s'       => \$json,
+            'cpu=i'        => \$cpu,
+            'translate:s'  => \$translate
+);
+
+help() if $help;
+help() unless ( $dir and $fasta ); # required options
+
+my $pfamA;
+if ( $only_pfamB or $pfamB ) {
+  die qq(FATAL: As of release 28.0, Pfam no longer produces Pfam-B. The -pfamB and -only_pfamB options are now obsolete.\n);
+  $pfamB=1;
+}
+else {
+  $pfamA=1;
+}
+
+my @hmmlib;
+push @hmmlib, 'Pfam-A.hmm' if $pfamA;
+push @hmmlib, 'Pfam-B.hmm' if $pfamB;
+
+#-------------------------------------------------------------------------------
+
+# check the input parameters
+
+die qq(FATAL: must specify both "-dir" and "-fasta")
+  unless ( defined $dir and defined $fasta );
+
+die qq(FATAL: can't find directory "$dir")
+  unless -d $dir;
+
+die qq(FATAL: can't find file "$fasta")
+  unless -s $fasta;
+
+foreach my $hmmlib ( @hmmlib ) {
+  die qq(FATAL: can't find "$hmmlib" and/or "$hmmlib" binaries and/or "$hmmlib.dat" file in "$dir")
+    unless ( -s "$dir/$hmmlib"     and 
+             -s "$dir/$hmmlib.h3f" and
+             -s "$dir/$hmmlib.h3i" and
+             -s "$dir/$hmmlib.h3m" and
+             -s "$dir/$hmmlib.h3p" and
+             -s "$dir/$hmmlib.dat" );
+}
+
+die qq(FATAL: can't use E-value or bit score threshold with Pfam-B searches; Pfam-B searches use a default cut_off of 0.001)
+  if ( ( $e_seq or $e_dom or $b_seq or $b_dom ) and not $pfamA ); 
+
+die qq(FATAL: can't use E-value and bit score threshold together)
+  if ( ( $e_seq and ( $b_seq or $b_dom ) ) or 
+       ( $b_seq and ( $e_seq or $e_dom ) ) or 
+       ( $b_dom and $e_dom ) );
+
+die qq(FATAL: output file "$outfile" already exists)
+  if ( $outfile and -s $outfile );
+
+if ( $as ) {
+  die qq(FATAL: "-as" option only works on Pfam-A families)
+    unless $pfamA;
+
+  die qq(FATAL: can't find "active_site.dat" in "$dir")
+    unless -s "$dir/active_site.dat";
+}
+
+if ( defined $translate ) {
+  if ( $translate eq "" ) {
+    # no argument to "-translate" was given, so make "orf" the default
+    $translate = 'orf';
+  }
+  else {
+    # there was an argument to "-translate", so make sure it's valid
+    unless ( $translate eq "all" or $translate eq "orf" ) {
+      die qq(FATAL: "-translate" option accepts only "all" and "orf");
+    }
+  }
+}
+
+#-------------------------------------------------------------------------------
+
+# build the object
+my $ps = Bio::Pfam::Scan::PfamScan->new(
+  -e_seq        => $e_seq,
+  -e_dom        => $e_dom,
+  -b_seq        => $b_seq,
+  -b_dom        => $b_dom,
+  -dir          => $dir,
+  -clan_overlap => $clan_overlap,
+  -fasta        => $fasta,
+  -align        => $align,
+  -as           => $as,
+  -hmmlib       => \@hmmlib,
+  -version      => $VERSION,
+  -cpu          => $cpu,
+  -translate    => $translate
+);
+
+# run the search
+$ps->search;
+
+# print the results
+if ( defined $json ) {
+
+  my $json_object;
+  eval {
+    require JSON;
+    $json_object = new JSON;
+  };
+  if ( $@ ) {
+    die qq(FATAL: can't load JSON module; can't write JSON-format output);
+  }
+
+  if ( $json eq 'pretty' ) {
+    $json_object->pretty( 1 ) ;
+  }
+  print $json_object->encode( $ps->results );
+
+}
+else {
+  $ps->write_results( $outfile, $e_seq, $e_dom, $b_seq, $b_dom );
+}
+
+exit;
+
+#-------------------------------------------------------------------------------
+
+sub help {
+  print STDERR <<EOF;
+
+pfam_scan.pl: search a FASTA file against a library of Pfam HMMs
+
+Usage: pfam_scan.pl -fasta <fasta_file> -dir <directory location of Pfam files>
+
+Additonal options:
+
+  -h                : show this help
+  -outfile <file>   : output file, otherwise send to STDOUT
+  -clan_overlap     : show overlapping hits within clan member families (applies to Pfam-A families only)
+  -align            : show the HMM-sequence alignment for each match
+  -e_seq <n>        : specify hmmscan evalue sequence cutoff for Pfam-A searches (default Pfam defined)
+  -e_dom <n>        : specify hmmscan evalue domain cutoff for Pfam-A searches (default Pfam defined)
+  -b_seq <n>        : specify hmmscan bit score sequence cutoff for Pfam-A searches (default Pfam defined)
+  -b_dom <n>        : specify hmmscan bit score domain cutoff for Pfam-A searches (default Pfam defined)
+  -as               : predict active site residues for Pfam-A matches
+  -json [pretty]    : write results in JSON format. If the optional value "pretty" is given,
+                      the JSON output will be formatted using the "pretty" option in the JSON
+                      module
+  -cpu <n>          : number of parallel CPU workers to use for multithreads (default all)
+  -translate [mode] : treat sequence as DNA and perform six-frame translation before searching. If the
+                      optional value "mode" is given it must be either "all", to translate everything 
+                      and produce no individual ORFs, or "orf", to report only ORFs with length greater 
+                      than 20. If "-translate" is used without a "mode" value, the default is to 
+                      report ORFs (default no translation)
+
+  For more help, check the perldoc:
+
+      shell\% perldoc pfam_scan.pl
+
+EOF
+  exit;
+
+}
+
+#-------------------------------------------------------------------------------
+
+=head1 NAME
+
+pfam_scan.pl -- Search protein sequences against the Pfam HMM library
+
+=head1 SYNOPSIS
+
+pfam_scan.pl [options] -fasta <fasta_file> -dir <Pfam_data_file_dir>
+
+=head1 OPTIONS
+
+=over
+
+=item B<-dir> I<Pfam_data_file_dir>
+
+Directory containing Pfam data files [required]
+
+=item B<-fasta> I<fasta_file>
+
+Filename of input file containing sequence(s) [required]
+
+=item B<-outfile> I<output_file>
+
+Write output to C<output_file> [default: STDOUT]
+
+=item B<-e_seq>
+
+Sequence E-value cut-off [default: use Pfam GA cutoff]
+
+=item B<-e_dom> 
+
+Domain E-value cut-off [default: use Pfam GA cutoff]
+
+=item B<-b_seq>
+
+Sequence bits score cut-off [default: use Pfam GA cutoff]
+
+=item B<-b_dom>
+
+Domain bits score cut-off [default: use Pfam GA cutoff]
+
+=item B<-clan_overlap>
+
+Allow sequences in different clans to overlap [default: false]
+
+=item B<-align>
+
+Show alignment snippets in results [default: false]
+
+=item B<-as>
+
+Search for active sites on Pfam-A matches [default: false]
+
+=item B<-json> [I<pretty>]
+
+Write the results in JSON format [default: false]
+
+=item B<-cpu>
+
+Number of parallel CPU workers to use for multithreads [default: all]
+
+=item B<-translate> [I<mode>]
+
+Treat the input sequence as DNA and perform a six-frame translation before
+searching, using the "translate" program from the HMMER v2.3.2 package. If the
+optional value I<mode> is given, it must be either "all" or "orf": "all" means
+translate in full, with stops, and produce no individual ORFs; "orf" means
+translate and report only ORFs of length greater than 20. If B<translate> is
+used but I<mode> is omitted, the default is to translate using the "orf"
+method [default: off (no translation)]
+
+=item B<-h>
+
+Display help message
+
+=back
+
+The input must be a FASTA-format file. The C<-fasta> and C<-dir> options are 
+mandatory. You cannot specify both an E-value and bits score threshold.  
+
+=head1 OVERVIEW
+
+C<pfam_scan.pl> is a script for searching one or more protein sequences against the
+library of HMMs from Pfam. It requires a local copy of the Pfam data files, which 
+can be obtained from the Pfam FTP area:
+
+  ftp://ftp.ebi.ac.uk/pub/databases/Pfam/current_release/
+
+You must also have the HMMER3 binaries installed and their locations given by your
+C<PATH> environment variable. You can download the HMMER3 package at:
+
+  ftp://selab.janelia.org/pub/software/hmmer3/
+
+=head1 OUTPUT
+
+The output format is:
+<seq id> <alignment start> <alignment end> <envelope start> <envelope end> <hmm acc> <hmm name> <type> <hmm start> <hmm end> <hmm length> <bit score> <E-value> <significance> <clan> <predicted_active_site_residues>
+Example output (-as option):
+
+  O65039.1     38     93     38     93 PF08246   Inhibitor_I29     Domain     1    58    58     45.9   2.8e-12   1 No_clan
+  O65039.1    126    342    126    342 PF00112   Peptidase_C1      Domain     1   216   216    296.0   1.1e-88   1 CL0125   predicted_active_site[150,285,307]
+
+Most of these values are derived from the output of I<hmmscan> (see HMMER3
+documentation for details). The significance value is 1 if the bit score for a
+hit is greater than or equal to the curated gathering threshold for the
+matching family, 0 otherwise. 
+
+=head1 REFERENCES
+
+Active site residues are predicted using the method described in the publication: 
+
+Mistry J., Bateman A., Finn R.D. "Predicting active site residue annotations in 
+the Pfam database." BMC Bioinformatics. 2007;8:298. PMID:17688688.
+
+=head1 AUTHORS
+
+Jaina Mistry (jaina@ebi.ac.uk), Rob Finn (rdf@ebi.ac.uk)
+
+=cut
+
+=head1 COPYRIGHT
+
+Copyright (c) 2009: Genome Research Ltd.
+
+Authors: Jaina Mistry (jaina@ebi.ac.uk), rdf (rdf@ebi.ac.uk)
+
+This is free software; you can redistribute it and/or
+modify it under the terms of the GNU General Public License
+as published by the Free Software Foundation; either version 2
+of the License, or (at your option) any later version.
+
+This program is distributed in the hope that it will be useful,
+but WITHOUT ANY WARRANTY; without even the implied warranty of
+MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+GNU General Public License for more details.
+
+You should have received a copy of the GNU General Public License
+along with this program; if not, write to the Free Software
+Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.
+or see the on-line version at http://www.gnu.org/copyleft/gpl.txt
+ 
+=cut
+
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/annota.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/annota.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,221 @@
+#!/usr/bin/perl -w
+
+use strict;
+my $d_file="/home/inmare/galaxy/tools/pfam_annot/pfamA.txt";
+open(IN,$d_file);
+my %decode=();
+my %clan_decode;
+my $id="";
+my %c=();
+
+
+my $prot_file=shift;
+my $pfam_file=shift;
+my $prefix=shift;
+
+while(<IN>)
+{
+        if ($_=~/^\d/)
+        {
+                my @vl=(split(/\t+/));
+		$decode{$vl[1]}="$vl[3]<br>";#$vl[8] $vl[9]";
+                my $cc=0;
+		my %repeated=();
+		foreach my $v (@vl)
+                {
+			$v=~s/\[\d+\]/ /g;
+			last if $v=~/hmmbuild/;
+			last if $cc>10;
+			next if $v=~/anon/;
+			next if $v=~/Bates/;
+			next if $v=~/Cogis/;
+			next if $v=~/Coggis/;
+			next if $v=~/Bateman/;
+			next if $v=~/Sonnhammer/;
+			next if $v=~/Finn/;
+			next if $v=~/Studholme/;
+			next if $v=~/Kerrison/;
+			next if $repeated{$v};
+			next if $v eq $vl[3];
+			next unless length($v)>=20 && $cc<=9;
+			$decode{$vl[1]}.="$v ";
+                	$repeated{$v}++;
+			$cc++;
+		}
+		#print "$vl[1] $decode{$vl[1]}\n";
+        }
+}
+close(IN);
+
+my $clan_file="/home/inmare/galaxy/tools/pfam_annot/clans.txt";
+open(IN,$clan_file);
+while(<IN>)
+{
+        my @vl=(split(/\t/));
+       	#$clan_decode{$vl[1]}="$vl[3]";
+	my $cc=0;
+        foreach my $v (@vl)
+	{
+		$cc++;
+		$v=~s/\[\d+\]/ /g;
+		$clan_decode{$vl[1]}.="$v " if length($v) >=30 && $cc<=10;
+	}	
+
+}
+my %plasm=();
+open(IN,"$prot_file");
+while(<IN>)
+{
+        if ($_=~/^>(.*)/)
+        {
+                $id=$1;	
+		$id=(split(/\s+/,$id))[0];
+		if ($id=~/#/)
+		{
+			my $pid=(split(/\#/,$id))[0];
+			$plasm{$pid}++;
+		}
+        }else{
+		chomp;
+                $c{$id}.=$_;
+        }
+}
+close(IN);
+
+open(OUT,">$prefix");
+print OUT "<html>\n<head>\n";
+print OUT "<style type=\"text/css\">\nspan {\n\ttext-decoration:underline;\n\tcolor:blue;\n\tcursor:pointer;\n}\n</style>\n";
+print OUT "<script>\nfunction show(elementID) {\n\tvar ele = document.getElementById(elementID);\n\tif (!ele) {\n\t\talert(\"no such element\");\t\treturn;\n\t}\n\tvar pages = document.getElementsByClassName('page');\n\tfor(var i = 0; i < pages.length; i++) {\n\t\tpages[i].style.display = 'none';\n\t}\n\tele.style.display = 'block';\n}\n</script>\n";
+#print OUT "<script src=\"script.js\"></script>\n";
+#print OUT "<script>\n\tshow(elementID)\n</script>\n";
+print OUT "</head>\n";
+my $color="\"#czb9dz\"";
+my %printed;
+open(IN,$pfam_file);
+print OUT "Proteins with PFAM domains:\n<br><br>\n";
+my @dd=keys %plasm;
+if ($#dd>0)
+{
+	print OUT "<p>Show results ";
+	for (my $i=0;$i<=$#dd;$i++)
+	{
+		if ($i==$#dd)
+		{
+			print OUT "<span onclick=\"show(\'$dd[$i]\');\">$dd[$i]</span>.</p>\n";
+		}else{
+			print OUT "<span onclick=\"show(\'$dd[$i]\');\">$dd[$i]</span>,\n"; 
+		}
+	}
+}else{
+	print OUT "<div>\n<table cellpadding=\"0\" width=650>\n"; #div per ogni plasmide|
+}
+my $ntokens=0;
+my $prev_plasmid="";
+my $curr_plasmid="";
+my $np=0;
+while(<IN>)
+{
+        next if $_=~/^\#/;
+        my ($name,$domain,$clan)=(split(/\s+/))[0,5,-1];
+        next unless $name;
+	if ($name=~/#/)
+        {
+        	$curr_plasmid=(split(/\#/,$name))[0];
+		if ($curr_plasmid ne $prev_plasmid)
+		{
+			if ($np>0)
+			{
+				print OUT "</table>\n";
+				print OUT "</div>\n";
+			}
+			print OUT "<div id=\"$curr_plasmid\" class=\"page\" style=\"\">\n";
+			print OUT "<table cellpadding=\"0\" width=650>\n";
+			$np++;
+		}
+		$prev_plasmid=$curr_plasmid;   
+        }
+
+        $domain=~s/\.\d+//;
+        unless ($printed{$name})
+	{
+		my $seq=$c{$name};
+		
+		$seq=~s/\*//g;
+		$seq=form($seq,90);
+		print OUT "<td>\n";
+		print OUT "<HR SIZE=3 WIDTH=80%></HR>\n";
+		print OUT "<center><b>$name</b><br>\n</center>\n";
+		print OUT "</td>\n<tr></tr>\n";
+                print OUT "<td bgcolor=$color>\n";
+		print OUT "<pre> \n$seq\n </pre>\n";
+		print OUT "</td>\n<tr></tr>\n<td></td>\n<tr></tr>\n";
+		$ntokens=2;
+	}
+	my $hd=uc $domain;
+	#<a href="http://www.canoro.altervista.org/" class="nav" target="_blank">www.canoro.altervista.org</a>
+	if ($decode{$domain})
+	{
+		my $ddes=$decode{$domain};
+		$ddes=~s/\s+/ /g;
+		if ($ntokens % 2==0)
+                {
+                        print OUT "<td>\n";
+                }else{
+                        print OUT "<td bgcolor=$color>\n";
+                }
+	
+		print OUT "<p align=\"left\">\n";
+        	print OUT "<a href=http://pfam.xfam.org/family/$hd> $domain</a>\n<p align=\"justify\">$ddes</p>\n\n";
+		print OUT "</p>\n</td>\n<tr></tr>\n<td></td>\n<tr></tr>\n";
+		$ntokens++;
+	}
+        if ($clan_decode{$clan})
+        {
+                my $clanD=$clan_decode{$clan};
+		$clanD=~s/\s+/ /g;
+		next if $decode{$domain} eq $clan_decode{$clan};
+		my $ddes=$decode{$domain};
+                if ($ntokens % 2==0)
+                {
+                        print OUT "<td>\n";
+                }else{
+                        print OUT "<td bgcolor=$color>\n";
+                }
+
+                print OUT "<p align=\"left\">\n";
+		print OUT "<a href=http://pfam.xfam.org/clan/$clan> $clan</a>\n <p align=\"justify\">$clanD</p>\n\n";
+		print OUT "</p>\n</td>\n<tr></tr>\n<td></td>\n<tr></tr>\n";
+		$ntokens++;
+        }
+        $printed{$name}=1;
+}
+
+#if ($curr_plasmid ne "")
+#{
+	print OUT "</table>\n";
+	print OUT "</div>\n";
+	print OUT "</body>\n";
+#}
+#print OUT "<br><br>Proteins without PFAM domains:\n<br>\n";
+#foreach my $seq (keys %c)
+#{
+#        next if $printed{$seq};
+#        print OUT "<>$seq</pre>\n\n<br><br><left>\n$c{$seq}</left><br>\n";
+#	print OUT "<HR SIZE=3 WIDTH=80%>\n";
+#}
+#print OUT "</table>\n</div>\n</body>\n</html>\n";
+#close(OUT);
+
+sub form
+{
+	my $string=$_[0];
+	my $len=$_[1];
+	my $outS="";
+	for (my $i=0;$i<=length($string);$i+=$len)
+	{
+		$outS.=substr($string,$i,$len)."\n";
+	}
+	#print "A:$outS";
+	#$outS=~s/\s+//g;
+	return $outS;
+}
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/clans.txt
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/clans.txt	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,515 @@
+1	CL0001	EGF	\N	EGF superfamily	Finn RD, Bateman A	anon	Members of this clan all belong to the EGF superfamily.  This particular superfamily is characterised as having least 6 cysteines residues.\	\	\	\	   These cysteine form disulphide bonds, in the order 1-3, 2-4, 5-6, which are essential for the stability of  the EGF fold.    These disulphide bonds are stacked in a ladder-like arrangement.  The Laminin EGF family is distinguished by having an an additional disulphide bond.  The function of the domains within  this family remains unclear, but they are though to largely  perform a structural role.  More often than not, there domains are arranged a tandem repeats in extracellular proteins.	2008-09-03 15:50:29	2004-03-17 16:02:08	26	325	6259	696	88541	1
+3	CL0003	SAM	\N	Sterile Alpha Motif (SAM) domain	Finn RD	anon	SAM domains are found in a diverse set of proteins, which include  scaffolding proteins, transcription regulators, translational  regulators tyrosine kinases and serine/threonine kinases [1-3].   SAM domains are found in all eukaryotes and some bacteria [3] .   Structures of SAM domains reveal a common five helical structure.  The SAM domain is involved in a variety of functions. The most widespread function is in domain-domain interactions.   The SAM domain performs domain-domain interactions using multifarious  arrangements of the SAM domain.  More recently, the SAM domain within  the Smaug protein has been demonstrated to bind to the Nanos 3' UTR translation control element (Rfam:RF00161) [3]. This clan currently only represents the diverse SAM domain family and does not contain the more divergent SAM/Pointed family (Pfam:PF02198).	2008-09-03 15:50:29	2004-03-17 16:21:50	20	126	742	467	11010	1
+4	CL0004	Concanavalin	\N	Concanavalin-like lectin/glucanase superfamily	Bateman A	anon	This superfamily includes a diverse range of carbohydrate binding domains and glycosyl hydrolase enzymes that share a common structure.	2008-09-03 15:50:29	2004-03-17 16:44:11	19	1631	2750	3131	34755	1
+5	CL0005	Kazal	\N	Kazal like domain	Finn RD	anon	Kazal domains are found in both serine protease inhibitors and extracellular regions of agrins. The structure of the Kazal domain is a small alpha/beta fold. Typically the Kazal domain consists of 2 short-helices and a  3-stranded anti-parallel sheet.  The fold is contains several disulphide bonds. 	2008-09-03 15:50:29	2004-03-17 17:00:11	26	106	337	450	6552	1
+6	CL0006	C1	\N	Protein kinase C, C1 domain	Finn RD	anon	The members of this clan are all variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content.  The C1 domain is the N-terminal region of conservation found in protein kinase C domains.  This domain is involved in binding many ligands, which include diacylglycerol, phorbol  esters and zinc [1].	2008-09-03 15:50:29	2004-03-17 17:47:56	19	30	728	396	10495	1
+7	CL0007	KH	\N	K-Homology (KH) domain Superfamily	Finn RD	anon	The KH domain is thought to be the second most prevalent RNA  binding motif in proteins.  The motif is characterised by a  conserved GXXXGXXG in the middle of the domain.  Structures of KH reveal that the KH domain is arranged as either a  beta-alpha-alpha-beta-beta (mini-KH domain) or  beta-alpha-alpha-beta-beta-alpha (maxi-KH domain).  The secondary elements are separated by at least four loop segments. The second loop is located between beta-1 and al  The KH domain can be found either as single or multiple copies.  The KH domain usually binds RNA as a multimer.	2008-09-03 15:50:29	2004-03-17 17:58:30	17	312	491	5344	38636	1
+9	CL0009	ENTH_VHS	\N	ENTH/ANTH/VHS superfamily	Bateman A, McMahon H	anon	This clan includes the related ENTH and ANTH domains as well as the VHS domain. The ENTH domain is approximately 150 residues in length and is a solenoid of alpha-helices. The various ENTH domains have various lipid specificities but the key feature that distinguishes it functionally from ANTH domains is its ability to bend membranes. It does  this by folding an additional N-terminal helix on lipid binding. The ANTH domain is approximately 300 residues in length and is a PtdIns(4,5)P2 binding domain. It has no membrane bending properties. The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking [5].	2008-09-03 15:50:29	2004-03-18 10:53:33	19	75	85	345	4028	1
+10	CL0010	SH3	\N	Src homology-3 domain	Finn RD	anon	Src homology-3 (SH3) domains are comprised of about 60 amino acids, performing either an assembly or regulatory role.\	       For example, SH3 domains in the Grb2 adaptor protein  are essential for protein-protein interactions and\	\	      signal transduction in the p21 Ras-dependent growth factor signaling pathway.  Alternatively, SH3 performs a regulatory role in the Src family of tyrosine kinases. SH3 domains bind a variety of peptide ligands, many of which  contain a PxxP motif.  This PxxP motif is flanked by different specificity elements [1].   Structures of SH3 domains, both free and ligand complexed, have provided insights into the mechanism of ligand recognition. The SH3 fold consists of two anti-parallel beta sheets that lie  at right angles to each other.  Within the fold, there are two variable loops, referred to as RT and n-Src loops.  When SH3 binds to its ligand, the proline rich ligand adopts a PPII helix conformation, with the PPII helix structure recognised by a pair of grooves on the surface of the SH3 domain that  bind turns of the helix.  The SH3 grooves  are formed by a series of nearly parallel, well-conserved aromatic residues [1].	2008-09-03 15:50:29	2004-03-18 11:12:55	20	564	2030	4044	40209	1
+11	CL0011	Ig	\N	Immunoglobulin superfamily	Bateman A, Finn RD	anon	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases.  Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The superfamily can be divided into discrete structural sets, by the presence or absence of beta-strands in the structure and the  length of the domains [1]. Proteins containing domains of the C1 and V-sets are mostly molecules of the vertebrate immune system. Proteins of the C2-set are mainly lymphocyte antigens, this differs from the composition of the C2-set as originally proposed [1]. The I-set is intermediate in structure between the C1 and V-sets and is found widely in cell surface proteins as well as intracellular muscle proteins.	2008-09-03 15:50:29	2004-03-18 16:23:40	25	3370	4292	3474	136715	1
+12	CL0012	Histone	\N	Histone superfamily	Bateman A	anon	Members of this clan all possess a histone fold. Generally proteins in this clan are DNA binding.	2008-09-03 15:50:29	2004-04-19 14:28:04	17	742	154	9904	23976	1
+13	CL0013	Beta-lactamase	\N	Serine beta-lactamase-like superfamily	Finn RD, Bateman A	anon	This superfamily contains proteins that have a beta-lactamase fold.  This includes beta-lactamases as well as Dala-Dala carboxypeptidases and glutaminases.	2008-09-03 15:50:29	2004-04-19 15:42:28	17	961	303	5474	58501	1
+14	CL0014	Glutaminase_I	\N	Class-I Glutamine amidotransferase superfamily	Bateman A	anon	Most members of this clan are glutaminase enzymes. This superfamily is shown to be related in [1]. The clan also contains the DJ-1/PfpI family that includes the peptidase PfpI that has a catalytic Cys-His-Glu triad that differs from the class I GAT Cys-His-Glu triad.	2008-09-03 15:50:29	2004-04-28 09:27:01	21	334	418	7216	67224	1
+15	CL0015	MFS	\N	Major Facilitator Superfamily	Bateman A	anon	The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].	2008-09-03 15:50:29	2004-04-30 16:48:27	19	22	846	6356	249360	1
+16	CL0016	PKinase	\N	Protein kinase superfamily	Studholme DJ	anon	This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.	2008-09-03 15:50:29	2004-06-11 14:28:37	21	3279	6514	9586	173964	1
+18	CL0018	bZIP	\N	bZIP-like leucine zipper	Studholme DJ	anon	This family of eukaryotic transcription factors contain a basic region adjacent to a leucine zipper.	2008-09-03 15:50:29	2004-06-16 18:30:26	14	321	111	611	8901	1
+20	CL0020	TPR		Tetratrico peptide repeat superfamily	Studholme DJ	anon	Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.	2008-09-03 15:50:29	2004-06-21 18:12:39	24	947	20914	6771	404043	1
+21	CL0021	OB	\N	OB fold	Studholme DJ, Bateman A	anon	The OB (oligonucleotide/oligosaccharide binding) was defined by Murzin [1]. The common part of the OB-fold, has a five-stranded beta-sheet coiled to form a closed beta-barrel. This barrel is capped by an alpha-helix located between the third and fourth strands [1].	2008-09-03 15:50:29	2004-06-22 18:31:10	17	1592	988	7656	210543	1
+22	CL0022	LRR		Leucine Rich Repeat	Studholme DJ	anon	Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.  This Pfam entry contains Leucine Rich Repeats not recognised by the Pfam:PF00560 model.	2008-09-03 15:50:29	2004-06-23 16:13:12	31	250	9511	3145	175606	1
+23	CL0023	P-loop_NTPase	AAA;	P-loop containing nucleoside triphosphate hydrolase superfamily	Studholme DJ	anon	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	2008-09-03 15:50:29	2004-06-23 17:05:20	33	5523	12211	50680	1511292	1
+25	CL0025	His_Kinase_A		His Kinase A (phospho-acceptor) domain	Studholme DJ	anon	This is the dimerisation and phospho-acceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea.  It comprises one of the fundamental units of the two-component signal transduction system [2-7].	2008-09-03 15:50:29	2004-06-29 14:19:46	13	497	5781	7648	242300	1
+26	CL0026	CU_oxidase	\N	Multicopper oxidase-like domain	Studholme DJ, Finn RD	anon	Many of the proteins in this family contain multiple similar  copies of this plastocyanin-like domain.	2008-09-03 15:50:29	2004-06-29 16:37:59	19	1015	245	19953	63536	1
+27	CL0027	RdRP	\N	RNA dependent RNA polymerase	Bateman A	anon	This clan represents the replicative  RNA dependent RNA polymerase. from a variety of RNA viruses [1].	2008-09-03 15:50:29	2004-08-26 14:33:23	14	852	1801	12549	220781	1
+28	CL0028	AB_hydrolase		Alpha/Beta hydrolase fold	Bateman A	anon	This catalytic domain is found in a very wide range of enzymes.	2008-09-03 15:50:29	2004-08-29 17:32:06	21	1989	2396	7428	180167	1
+29	CL0029	Cupin		Cupin fold	Bateman A	anon	This clan represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). The cupin fold is found in a wide variety of enzymes, but notably contains the non-enzymatic seed storage proteins also.	2008-09-03 15:50:29	2004-09-06 15:03:53	19	945	1162	6529	112082	1
+30	CL0030	Ion_channel	\N	Ion channel (VIC) superfamily	Bateman A	anon	This superfamily contains a diverse range of ion channels that share a pair of transmembrane helices in common. This clan is classified as the VIC (Voltage-gated Ion Channel) superfamily in TCDB.	2008-09-03 15:50:29	2004-09-08 16:21:26	15	718	809	5250	44250	1
+31	CL0031	Phosphatase	\N	Phosphatase superfamily	Bateman A	anon	This family includes tyrosine and dual specificity phosphatase enzymes.	2008-09-03 15:50:29	2004-10-26 13:53:48	12	480	558	2966	20482	1
+32	CL0032	Dim_A_B_barrel	\N	Dimeric alpha/beta barrel superfamily	Bateman A	anon	This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel.  The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases.	2008-09-03 15:50:29	2004-10-26 16:31:17	14	510	186	4601	39476	1
+33	CL0033	POZ	\N	POZ domain superfamily	Bateman A	anon	The POZ domain is found in a variety of transcription factors.  POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.	2008-09-03 15:50:29	2004-10-27 13:52:11	13	223	1167	1178	26677	1
+34	CL0034	Amidohydrolase	\N	Amidohydrolase superfamily	Bateman A	anon	This family includes a large family of metal dependent amidohydrolase enzymes [1].	2008-09-03 15:50:29	2004-10-27 17:19:50	14	704	479	5687	79783	1
+35	CL0035	Peptidase_MH	\N	Peptidase clan MH/MC/MF	Bateman A	anon	This clan contains peptidases belonging to MEROPS clan MH, MC and MF.  We also include Nicastrin that is part of the gamma secretase complex and not known to be a peptidase.	2008-09-03 15:50:29	2004-10-28 13:48:22	15	680	539	5405	63766	1
+36	CL0036	TIM_barrel		Common phosphate binding-site TIM barrel superfamily	Bateman A	anon	This large superfamily of TIM barrel enzymes all contain a common phosphate binding site. The phosphate is found in a variety of cofactors and ligands such as FMN [1,2].	2008-09-03 15:50:29	2004-10-28 15:12:01	23	3964	973	10099	253453	1
+37	CL0037	Lysozyme	\N	Lysozyme-like superfamily	Bateman A	anon	Barley chitinase, bacterial chitosanase, and lysozymes from phage and animals all hydrolyse related polysaccharides. The proteins little amino-acid similarity, but have a structurally invariant core consisting of two helices and a three-stranded beta-sheet which form the substrate-binding and catalytic cleft [1].	2008-09-03 15:50:29	2004-10-28 15:30:21	13	1502	527	5612	33680	1
+39	CL0039	HUP	PP-loop; PP-ATPase;	HUP - HIGH-signature proteins, UspA, and PP-ATPase.	Bateman A, Anantharaman V	anon	The HUP class contains the HIGH-signature proteins, UspA superfamily and the PP-ATPase superfamily [1]. The HIGH superfamily has the HIGH Nucleotidyl transferases and the class I tRNA synthetases both of  which have the HIGH and the KMSKS motif [1],[2]. The PP-loop ATPase  named after the ATP PyroPhosphatase domain, was initially  identified as a conserved amino acid sequence motif in four distinct groups of enzymes that catalyse the hydrolysis of the alpha-beta phosphate bond of ATP, namely GMP synthetases, argininosuccinate synthetases, asparagine synthetases, and ATP sulfurylases [3]. The USPA superfamily  contains USPA, ETFP and Photolyases [1]	2008-09-03 15:50:29	2004-10-29 14:36:02	11	1108	838	6582	177746	1
+40	CL0040	tRNA_synt_II	\N	Class II aminoacyl-tRNA and Biotin synthetases	Finn RD	anon	Aminoacyl-tRNA synthetases are key components of the protein translation  machinery that catalyse two basic reactions. First, the activation of  amino acids via the formation of aminoacyl adenylates and second, linking the activated amino acid to the cognate tRNAs. The aminoacyl-tRNA synthetases generate AMP as the second end product of this reaction, which differentiates them from the majority of ATP-dependent enzymes that produce ADP. In addition, there is a specific  aminoacyl-tRNA synthetases for each of the 20 amino acids and there are  two structurally distinct classes of aminoacyl-tRNA synthetases, each\	\	  encompassing 10 different specificities. The two classes have alternative modes of aminoacylation: class I aminoacylate the 2'OH of the cognate tRNA; class II aminoacylate 3'OH (with the exception of PheRS). Each class contain a conserved core domain  that is involved in ATP binding and hydrolysis and combines with  additional domains that determine the specificity of interactions with\	       the cognate amino acid and tRNA.  The class II core domain consist of a mixed-beta sheet, similar to that found in the biotin synthetases, hence why this family has also been included in  this clan.  The core domain contains three modestly conserved motifs  that are responsible for ATP binding.  The class II aminoacyl-tRNA  synthetases can contain additional nested domains, found inserted in the loops of the core domain [1] (and  reference therein).	2008-09-03 15:50:29	2004-11-08 11:24:57	16	514	340	5927	72316	1
+41	CL0041	Death	\N	Death Domain Superfamily	Finn RD	anon	The death domain superfamily is composed of three families: the death domain (DD); the death effector domain (DED) and the caspase recruitment domain (CARD).  All of the members perform a pivotal role in signalling events that regulate apoptosis.   Protein-protein interactions are mediated by self-self associations, in which CARD-CARD, DD-DD and  DED-DED contacts are formed exclusively The three families possess remarkably similar structures, each comprising an antiparallel six helical bundle in the Greek Key topology.  Structurally, the DD and CARD families are the most dissimilar.  The former is comprised of two perpendicular three-helix bundles, whereas the latter CARD domain contains six helices that are almost parallel with each other.  Interestingly, the interactions in CARD or DD containing heterodimers are quite different [1]. 	2008-09-03 15:50:29	2004-11-11 10:28:31	12	135	742	249	6544	1
+42	CL0042	Flavoprotein	\N	Flavoprotein	Finn RD	anon	Members of this clan are FMN or FAD-binding redox proteins.  Flavoproteins act in various electron-transport systems as  functional analogues of ferredoxin.  They are characterised by an open twisted alpha/beta structure consisting of five parallel  beta-sheets connected by alpha-helices which surround the sheet.	2008-09-03 15:50:29	2004-11-12 15:13:12	11	497	221	5019	35666	1
+43	CL0043	Chelatase	\N	Chelatase Superfamily	Finn RD	anon	Metallated tetrapyrroles are used as prosthetic groups in  proteins involved in biologically important processes such as  photosynthesis, oxygen transport, drug metabolism and  nitric oxide synthesis. In living organisms, metallation is catalysed  by a group of enzymes called chelatases. This clan contains  ferrochelatase (heme) and cobalt chelatase [1]. 	2008-09-03 15:50:29	2004-11-12 16:49:49	11	77	45	4178	7625	1
+44	CL0044	Ferritin		Ferritin-like Superfamily	Finn RD	anon	The members of this clan all share a distinctive four helical bundle. The four helices are arranged antiparallel with a left-handed twist. This helical bundle is distinguished from others by the long connection between the second and third helices.  Some of the members contain a Fe or Mn dimer at the centre of the helical bundle.  The ferritin fold was first described by Murzin AG and Chothia C, Cur Opin Struc Biol 1992, 2:895-903.	2008-09-03 15:50:29	2004-11-12 17:32:27	13	2058	121	6054	34310	1
+45	CL0045	Rubredoxin	\N	Rubredoxin-like	Finn RD	anon	The Rubredoxin clan is comprised of three families:Rubredoxin, COX5B and desulforedoxin.Rubredoxin domains are small domains  (5-6 kDa) and bind one iron atom tetrahedrally bound by four cysteine  residues.Similar, desulforedoxin domains are small (4 kDa), but  usually form homodimers.  Each monomer binds one iron atom, but in  a distorted tetrahedral arrangement.  COX5B domains are membrane-anchored  rubredoxin-like domains. The domain in the Rubredoxin clan are usually comprised of 2 alpha helixes and 2-3 beta strands.	2008-09-03 15:50:29	2004-11-15 11:37:59	11	172	52	2672	4680	1
+46	CL0046	Thiolase	\N	Thiolase-like Superfamily	Finn RD	anon	Thiolases are ubiquitous and form a large superfamily. Thiolases can function either degradatively, in the beta-oxidation  pathway of fatty acids, or biosynthetically. Biosynthetic thiolases  catalyse the formation of acetoacetyl-CoA from two molecules of  acetyl-CoA . This is one of the fundamental categories of carbon  skeletal assembly patterns in biological systems and is the first step  in a wide range of biosynthetic pathways [1].  Thiolase are usually dimeric or tetrameric enzymes.  Within each monomer there are two similar domains related by pseudo dyad.  The N-terminal of these two domains contains a large insertion of about 100 amino  acids.	2008-09-03 15:50:29	2004-11-15 12:47:24	15	575	1810	7516	102610	1
+47	CL0047	CuAO_N2_N3	\N	Copper amine oxidase, domains 1 and 2	Finn RD	anon	Copper amine oxidase (CuAO) are comprised of three of four domains. In the case of the four domain CuAO, the N-terminal domain (termed N1, and is not present in the three domain CuAO) and the C-terminal catalytic domain sandwich two repeated domains (termed N2 and N3).  The function of these two homologous domains is uncertain.  N2 and N3 both have a cystatin-like fold [1].	2008-09-03 15:50:29	2004-11-15 13:04:24	11	186	31	504	1887	1
+48	CL0048	LolA_LolB	\N	Lipoprotein localisation factors LolA/B	Finn RD	anon	Gram-negative bacteria lipoproteins are anchored to the periplasmic  surface of the inner or outer membrane depending on the sorting signal, which is the residue at position 2 of the polypeptide. Five Lol proteins  are involved in the sorting and membrane localisation of lipoprotein. An ATP-binding cassette (ABC) transporter, LolCDE, releases outer  membrane-specific lipoproteins from the inner membrane, causing the  formation of a complex between the released lipoproteins and the  periplasmic molecular chaperone LolA. When this complex interacts with  outer membrane receptor LolB, the lipoproteins are transferred from LolA  to LolB and then localised to the outer membrane. The structures of LolA  and LolB are remarkably similar to each other. Both have a hydrophobic  cavity consisting of an unclosed beta-barrel and an alpha-helical  lid [1,2].	2008-09-03 15:50:29	2004-11-15 13:13:26	11	10	5	2158	3976	1
+49	CL0049	Tudor	\N	Tudor domain 'Royal family'	Finn RD, Bateman A	anon	This clan covers the Tudor domain 'royal family' [1]. This includes chromo, MBT, PWWP and tudor domains.  The chromo domain is a comprised of approximately 50 amino acid residues. There are usually one to three Chromo domains found in a single protein. In some chromo domain containing proteins, a second related chromo domain has been found and is referred to as the Chromo-shadow domain.  The structure of the Chromo and Chromo-shadow domains reveal an OB-fold, a fold found in a variety of prokaryotic and eukaryotic nucleic acid binding proteins.\	More specifically,the chromo-domain structure reveals a three beta strands that are packed against an alpha helix. Interestingly, a similar structure is found in the archaeal chromatin proteins (7kDa DNA-binding domain).  These are sequence neutral DNA binding proteins.\	The DNA binding in these archaeal proteins is mediated through the triple stranded beta sheet. These archaeal domains are though to represent an ancestral chromo domain. Homologs of the chromo domain have been found in fission yeast, ciliated protozoa and all animal species, but appear to be absent in eubacteria, budding yeast and plants [2]. The precise function of the chromo domain is unclear, but the chromo domain is thought to act as a targeting module for chromosomal proteins, although the chromosomal contexts and functional contexts being targeted vary.  In all cases studies, the chromo domains are found in proteins that are involved in transcription regulation, positive and negative [2].	2008-09-03 15:50:29	2004-11-16 16:02:09	14	325	682	504	17304	1
+50	CL0050	HotDog	\N	HotDog superfamily	Bateman A	anon	The HotDog fold was first observed in the structure of Escherichia coli beta-hydroxydecanoyl thiol ester dehydratase (FabA), where Leesong et al. noticed that each subunit of this dimeric enzyme contained a mixed alpha + beta 'hot dog' fold. They described the seven-stranded antiparallel beta-sheet as the 'bun', which wraps around a five-turn alpha-helical 'sausage', This superfamily contains a diverse range of enzymes. Membership includes numerous prokaryotic, archaeal and eukaryotic proteins involved in several related, but distinct, catalytic activities, from metabolic roles such as thioester hydrolysis in fatty acid metabolism, to degradation of phenylacetic acid and the environmental pollutant 4-chlorobenzoate. The superfamily also includes FapR, a non-catalytic bacterial homologue that is involved in transcriptional regulation of fatty acid biosynthesis [1].	2008-09-03 15:50:29	2004-11-19 13:30:09	11	673	1411	5349	52323	1
+51	CL0051	NTF2		NTF2-like superfamily	Bateman A	anon	This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.	2008-09-03 15:50:29	2004-11-19 15:35:00	13	603	332	4350	23892	1
+52	CL0052	NTN	\N	NTN hydrolase superfamily	Bateman A	anon	In the N-terminal nucleophile aminohydrolases (Ntn hydrolases) the N-terminal residue provides two catalytic groups, nucleophile and proton donor. These enzymes use the side chain of the amino-terminal residue, incorporated in a beta-sheet, as the nucleophile in the catalytic attack at the carbonyl carbon. The nucleophile is cysteine in GAT, serine in penicillin acylase, and threonine in the proteasome. All the enzymes share an unusual fold in which the nucleophile and other catalytic groups occupy equivalent sites. This fold provides both the capacity for nucleophilic attack and the possibility of autocatalytic processing [1].	2008-09-03 15:50:29	2004-11-19 17:25:18	17	2263	255	5468	47927	1
+53	CL0053	4H_Cytokine		4-helical cytokine superfamily	Bateman A	anon	Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.	2008-09-03 15:50:29	2004-11-21 12:08:45	14	272	33	865	5160	1
+54	CL0054	Knottin_1	\N	Scorpion toxin-like knottin superfamily	Bateman A	anon	This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.	2008-09-03 15:50:29	2004-11-22 17:39:28	12	164	12	369	2025	1
+55	CL0055	Viral_ssRNA_CP	\N	Positive stranded ssRNA viruses coat protein	Finn RD	anon	The clan contains a set of viral coat protein families and peptidase A6. The only known peptidase  activity is an autolytic cleavage releasing a 44-residue  C-terminal fragment. The reaction is very slow and only occurs  within the assembled virion. There is debate whether this is actually a true peptidase. The virion with these coat or capsid\	proteins are icosahedral viruses containing sixty triangular  coat protein units, each unit consisting of three proteins. The coat  protein consists of two subdomains, an eight-stranded beta-barrel on  the surface and a three-helix bundle on the inner face.	2008-09-03 15:50:29	2004-11-24 13:16:32	12	790	144	9475	53300	1
+56	CL0056	C_Lectin	\N	C-type lectin-like superfamily	Bateman A	anon	This clan contains domains that have a C-type lectin fold.  Many of these are known or expected to  mediate interactions with sugars.	2008-09-03 15:50:29	2004-11-24 13:34:58	11	581	825	748	15749	1
+57	CL0057	Met_repress		MetJ/Arc repressor superfamily	Bateman A	anon	This superfamily contains the MetJ and Arc repressors that feature a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA [1].	2008-09-03 15:50:29	2004-11-24 15:10:49	13	185	88	3932	18127	1
+58	CL0058	Glyco_hydro_tim		Tim barrel glycosyl hydrolase superfamily	Bateman A	anon	This large superfamily contains a range of glycosyl hydrolase enzymes that possess a TIM barrel fold. This CLAN merges clans GH-A, GH-D, GH-H and GH-K from CAZy.	2008-09-03 15:50:29	2004-11-25 11:37:58	15	2459	2481	7032	114169	1
+59	CL0059	6_Hairpin		Six-hairpin glycosidase superfamily	Bateman A	anon	This Clan includes CAZy clans GH-L, GH-M and GH-G. The members of this clan share a common structure composed of 6 helical hairpins. Most members of this superfamily are glycosyl hydrolase enzymes.	2008-09-03 15:50:29	2004-11-26 15:47:32	14	530	867	4822	41246	1
+60	CL0060	DNA_clamp	\N	DNA clamp superfamily	Bateman A	anon	Sliding DNA clamps are ring-shaped proteins that allow DNA polymerase to achieve high processivity during chromosome replication by tethering the polymerase catalytic subunit to DNA. All of the structures share a 12-fold symmetry around the ring consisting of a simple structural repeat, though there is structural divergence in some of the repeats. Bacterial beta-clamps contain six repeats per subunit with two subunits per ring while the eukaryotic and bacteriophage clamps contain four repeats per subunit with three subunits per ring. Pairs of these repeats form a domain, which has been termed the 'processivity fold'; thus the ring of the sliding clamp contains six domains and therefore is often described as having 6-fold symmetry. A structural representative of a fourth family of processivity fold proteins, namely the herpes simplex virus UL42 protein, is also available. UL42 does not form a ring-shaped clamp, however, but rather functions as a monomer and interacts with DNA quite differently than do sliding clamps; it has been suggested that UL42 resembles a primitive ancestor of sliding clamps [2].	2008-09-03 15:50:29	2004-11-26 17:13:41	11	241	64	5243	18116	1
+61	CL0061	PLP_aminotran	\N	PLP dependent aminotransferase superfamily	Bateman A	anon	This superfamily contains a variety of PLP-dependent enzymes.	2008-09-03 15:50:29	2004-11-29 11:27:35	12	1560	574	7712	152775	1
+62	CL0062	APC		APC superfamily	Bateman A	anon	This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.	2008-09-03 15:50:29	2004-11-29 18:13:15	12	36	417	5587	126928	1
+63	CL0063	NADP_Rossmann		FAD/NAD(P)-binding Rossmann fold Superfamily	Finn RD	anon	A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site [1].  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD.	2008-09-03 15:50:29	2004-11-30 13:45:28	24	8681	8330	18998	984446	1
+64	CL0064	CPA_AT	\N	CPA/AT transporter superfamily	Bateman A	anon	This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB [1].	2008-09-03 15:50:29	2004-12-02 10:12:55	11	10	163	5252	48799	1
+65	CL0065	Cyclin	\N	Cyclin-like superfamily	Bateman A	anon	This Clan contains cyclins, Transcription factor IIB (TFIIB), and the Retinoblastoma tumour suppressor proteins. These were predicted to be related by sequence [1].	2008-09-03 15:50:29	2004-12-02 13:15:02	14	236	144	804	14080	1
+66	CL0066	Trefoil	\N	Beta-trefoil superfamily	Bateman A	anon	This family corresponds to a large set of related beta-trefoil proteins [1].  The beta-trefoil is formed by six two-stranded hairpins [2]. Three of these form a barrel structure and the other three are in a triangular array that caps the barrel. The arrangement of the secondary structures gives the molecules a pseudo 3-fold axis.	2008-09-03 15:50:29	2004-12-06 15:34:20	13	659	720	1705	12929	1
+67	CL0067	SIS	\N	SIS domain fold	Bateman A	anon	This catalytic domain catalyses isomerisation reactions of a variety of sugars [1].	2008-09-03 15:50:29	2004-12-06 16:11:44	12	275	84	6149	42474	1
+68	CL0068	RIIa	\N	RIIa-like fold	Bateman A	anon	This clan includes both the RIIa dimerisation motif as well as the Dpy-30-like motif [1].	2008-09-03 15:50:29	2004-12-07 15:58:47	11	37	67	303	1405	1
+69	CL0069	GFP	\N	GFP-like superfamily	Bateman A	anon	This superfamily has an unusual fold of an 11 stranded beta barrel enclosing an alpha-helix. This superfamily includes green fluorescent protein as well as a domain from nidogen.	2008-09-03 15:50:29	2004-12-08 17:25:21	11	623	171	194	602	1
+70	CL0070	ACT	\N	ACT-like domain	Bateman A	anon	These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains [1]. The relationship between these two families was first noticed in [2].	2008-09-03 15:50:29	2004-12-08 17:26:00	12	241	221	4906	47783	1
+71	CL0071	His_phosphatase	PGM;	Histidine phosphatase superfamily	Finn RD, Rigden DJ	anon	The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue.\	Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches [1].	2008-09-03 15:50:29	2004-12-09 14:54:21	11	292	168	4773	26470	1
+72	CL0072	Ubiquitin	\N	Ubiquitin superfamily	Bateman A	anon	This family includes proteins that share the ubiquitin fold. It currently unites four SCOP superfamilies.	2008-09-03 15:50:29	2004-12-09 18:04:44	19	1053	1522	6169	107825	1
+73	CL0073	P53-like	\N	Beta-sandwich DNA-binding domain	Bateman A	anon	This clan contains a variety of DNA-binding domains that contain an immunoglobulin-like fold. It includes the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, the T-domain and the Runt domain [1].	2008-09-03 15:50:29	2004-12-10 09:44:45	12	340	136	553	5385	1
+74	CL0074	Matrix	\N	Retroviral matrix superfamily	Bateman A	anon	This clan brings together matrix proteins from a variety of retroviruses.	2008-09-03 15:50:29	2004-12-10 10:07:15	12	41	88	280	38433	1
+75	CL0075	Defensin	\N	Defensin/myotoxin-like superfamily	Bateman A	anon	This clan includes diverse defensins as well as myotoxins.	2008-09-03 15:50:29	2004-12-10 13:40:46	12	146	13	137	1375	1
+76	CL0076	FAD_Lum_binding	\N	Riboflavin synthase/Ferredoxin reductase FAD binding domain	Finn RD	anon	Riboflavin nucleotide coenzymes and flavin adenine dinucleotide (FAD) are essential cofactors for a large number of flavoproteins involved in a diverse set of redox reactions.  There are thought to be four different FAD-binding folds [1].The FAD-binding fold of this clan is a cylindrical  beta-fold. More specifically, the domain forms a flattened six-stranded  antiparallel beta-barrel organised into two orthogonal sheets  (1-2-5 and 4-3-6) separated by one alpha-helix. The cylinder is open  between strands strand 4 and 5. This opening of the cylinder makes space  for the isoalloxazine and ribityl moieties of the FAD, to which hydrogen  bonds are formed from the open edges of the strands. The other end of  the cylinder is covered by the only helix of the domain,  which is essential for the binding of the pyrophosphate groups of the  FAD [1].The structural differences in the FAD-binding domain are  manifested mainly as loops of different length and extra extending  structural elements, which may be important for interactions with their  redox partners [1]. The structural core of all clan members is highly  conserved.	2008-09-03 15:50:29	2004-12-10 14:19:14	11	202	346	5130	31559	1
+77	CL0077	FAD_PCMH	\N	PCMH-like FAD binding	Finn RD	anon	The FAD-binding domains contained in this family fall within the PCMH (p-cresol methyl-hydroxylase) family of FAD binding proteins as defined in [1].  In this family, the structure of the FAD binding domain is comprised of two subdomains.  Both of these subdomains have an alpha-beta fold.  The first subdomain is comprised of three parallel beta strands,  surrounded by alpha helices.  The second subdomain contains five antiparallel beta strands, also surrounded by alpha helices. The junction between these two subdomains forms the FAD bind pocket, where the ligand is bound by hydrogen and van der Waals bonds [1].	2008-09-03 15:50:29	2004-12-10 16:27:25	11	247	229	5425	25538	1
+78	CL0078	DNA_ligase	\N	DNA/RNA ligase superfamily	Bateman A	anon	This superfamily contains both ATP-dependent and NAD dependent DNA ligase enzymes.  The family also includes mRNA capping enzymes.  The members of this clan were shown to be related by sequence in [1].	2008-09-03 15:50:29	2004-12-10 18:04:20	12	72	170	5269	10191	1
+79	CL0079	Cystine-knot	\N	Cystine-knot cytokine superfamily	Bateman A	anon	The cytokine families in this clan have the cystine-knot fold.  In this 6 cysteines form three disulphide bridges that are interlinked.	2008-09-03 15:50:29	2004-12-14 17:03:09	12	253	73	2754	10562	1
+80	CL0080	Mss4-like	\N	Mss4-like superfamily	Bateman A	anon	This clan contains TCTP, Mss4 and SelR families [1].	2008-09-03 15:50:29	2004-12-14 17:24:43	11	51	31	4242	6196	1
+81	CL0081	MBD-like	\N	MBD-like DNA-binding domain	Bateman A	anon	This clan contains proteins with a distinctive three stranded DNA-binding domain [1].	2008-09-03 15:50:29	2004-12-14 17:44:54	12	24	149	2355	10578	1
+82	CL0082	MIF	\N	Tautomerase/MIF superfamily	Bateman A	anon	This clan groups 5-(carboxymethyl)-2-hydroxymuconate isomerase (CHMI) and 4-oxalocrotonate tautomerase (4-OT) with macrophage inhibitory factor (MIF).  Interestingly they all share an amino-terminal proline. Members of this clan for homotrimers [1].	2008-09-03 15:50:29	2004-12-15 11:44:36	11	347	29	3218	5290	1
+83	CL0083	Omega_toxin		Omega toxin-like	Finn RD	anon	This clan contains a set of related small protein toxins and what appears to be the functionally distinct Albumin I domain. All members of this clan have a knottin-like fold.  Additional information about this clan may be found from [1].  	2008-09-03 15:50:29	2004-12-16 13:53:46	14	83	23	290	1853	1
+84	CL0084	ADP-ribosyl	\N	ADP-ribosylation Superfamily	Finn RD	anon	The members of this clan all represent ADP-ribosylating catalytic domains.  The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is  thought to have an "unusual fold".	2008-09-03 15:50:29	2004-12-16 14:31:35	12	208	320	842	3271	1
+85	CL0085	FAD_DHS	\N	DHS-like NAD/FAD-binding domain	Finn RD	anon	The members of this family adopt a Rossmann fold, similar to CLAN:CL0063. However, the members of this family are distinguished in that the FAD/NAD cofactor is bound in the opposite direction.  In this arrangement, the adenosine moiety is found bound at the  second half of the fold.\	   In addition, the conserved GxGxxG motif found in classical NADP binding Rossmann folds is absent.  Finally, another distinguishing characteristic is the formation of an internal hydrogen bond in the FAD molecule [1].	2008-09-03 15:50:29	2004-12-16 15:32:59	13	399	174	5116	30822	1
+86	CL0086	FAD_oxidored	\N	FAD-linked oxidoreductase	Finn RD	anon	The members of this clan adopt a TIM barrel fold, which is reminiscent of flavin mononucleotide binding proteins, rather than one similar to other flavin adenine dinucleotide binding domains. However, the way the FAD cofactor binds in quite different compared to  the binding of FMN in the TIM-barrel structures [1].	2008-09-03 15:50:29	2004-12-16 16:43:38	11	60	30	4179	7837	1
+87	CL0087	Acyl-CoA_dh	\N	Acyl-CoA dehydrogenase, C-terminal domain-like	Finn RD	anon	The Acyl-CoA dehydrogenase FAD binding domain forms an mostly alpha helical domain, comprised of four helices\	arranged in up-and-down bundle. In Acyl-CoA oxidase II this domain appears to have been duplicated.	2008-09-03 15:50:29	2004-12-17 10:15:37	12	254	148	3538	31652	1
+88	CL0088	Alk_phosphatase	\N	Alkaline phosphatase-like	Finn RD	anon	The members of this clan all share a common structure of their catalytic domains, which contain conserved metal binding residues [1].	2008-09-03 15:50:29	2004-12-17 11:25:45	15	217	321	5028	38421	1
+89	CL0089	GlnB-like	\N	GlnB-like superfamily	Finn RD	anon	The members of this clan are characterised by the fact the domains, each comprised of four beta-strand and two alpha helices, tend to form tetrameric structures [1].	2008-09-03 15:50:29	2004-12-17 12:10:20	12	264	47	4170	11982	1
+90	CL0090	Globin	\N	Globin-like	Finn RD	anon	The globin fold is an evolutionary conserved six helical fold that is  found in bacteria and eukaryotes.	2008-09-03 15:50:29	2004-12-17 12:17:06	11	2247	121	4808	13282	1
+91	CL0091	NAD_Ferredoxin	\N	Ferredoxin / Ferric reductase-like NAD binding	Finn RD	anon	The Ferredoxin / Ferric reductase-like NAD binding domain is  adopts a Rossmann like fold.  However, these families have been excluded from the classical NAD(P) binding Rossmann clan (CLAN:CL0063), due to a divergence of the GxGxxG motif.  In this clan, the motif phosphate binding motif is G-T/S-G-A/I-P.  The changes in the motif are a reflection of the different way that the NAD(P)H is bound by this fold and the classical Rossmann fold [1,2].	2008-09-03 15:50:29	2004-12-17 14:54:00	11	192	335	4749	22088	1
+92	CL0092	ADF	\N	Actin depolymerizing Factor	Finn RD	anon	For motile cells such as Amoeba to move, there must be the rapid recycling of their actin cytoskeleton to enable a dynamic change in their shape. Gelsolin (PFAM:PF00626) and Cofilin (PFAM:PF00241) are  two key domain families in this process.  Both of these domain are  structural and functional similar [1,2].  In particular, the beta sheet found at the core of the domain is structurally well conserved, with the helices that surround this sheet less conserved[2]. 	2008-09-03 15:50:29	2004-12-17 17:36:22	11	154	175	529	7818	1
+93	CL0093	Peptidase_CD	\N	Peptidase clan CD	Finn RD	anon	The members of this clan are all endopeptidase that have the catalytic dyad histidine followed by cysteine.  The catalytic histidine is preceded  by a block of hydrophobic residues and a glycine, where as the cysteine is preceded by a block of hydrophobic residues and a glutamine and an alanine. The members with a know structure adopt an alpha/beta fold [1].	2008-09-03 15:50:29	2004-12-21 13:25:00	13	474	1163	1706	9782	1
+94	CL0094	Peptidase_ME	\N	LuxS/MPP-like metallohydrolase	Finn RD	anon	All members of this clan are characterised by a HXXEH motif, which is  is involved in zinc binding.  Furthermore all members adopt an alpha and  beta fold. More specifically, there us a four to six stranded antiparallel beta sheet surrounded by five helices. However, LuxS (PFAM:PF02664) is not a peptidase, although its hydrolytic mechanism of catalysis appears to be conserved [1].	2008-09-03 15:50:29	2004-12-21 13:57:38	11	224	73	4739	30361	1
+95	CL0095	Peptidase_ML	\N	Peptidase Clan ML	Finn RD	anon	This clan contains HybD-like domains.  HybD is a nickel binding  endopeptidase.  Structural and sequences analyses have highlighted the  presence of two highly conserved motifs that are shared with germination proteases and HybD [1].  Members of this clan adopt an alpha/beta fold,  comprised of a central beta sheet, surrounded by alpha helices.	2008-09-03 15:50:29	2004-12-21 15:54:20	12	12	11	1706	3673	1
+96	CL0096	Pept_Inhib_IE	\N	Peptidase Inhibitor Clan IE	Finn RD	anon	The members of this clan are all cystine rich domains, which form a knottin scaffold.  This clan should also contain alpha-amylase but currently this family is a singleton and can not be put into Pfam. Also see [1].	2008-09-03 15:50:29	2004-12-22 12:16:32	11	34	2	22	52	1
+97	CL0097	TypeIII_Chap	\N	Type III secretory system chaperone	Finn RD	anon	The translocation of pathogenic proteins into a host cell is mediated by the type III secretory system. A component of this system is a  chaperone, which binds to the protein which is going to be secreted in the bacterial cytosol and is involved in translocation of the secreted  protein, although the chaperone is not translocated itself. An individual  chaperone associates with one or two specific proteins [1].  There are a large number of type III secretory system chaperones, which are small acidic proteins and exhibit significant sequence divergence.   This clan groups type III secretory system chaperones. Members with a  known structure form small compact globular domains with an alpha-beta(3)- alpha-beta(2)-alpha like organisation [1].	2008-09-03 15:50:29	2004-12-22 12:58:31	11	45	14	1697	3343	1
+98	CL0098	SPOUT	AB_Knot;	SPOUT Methyltransferase Superfamily	Finn RD	anon	A distinct class of methylases that includes the SpoU and TrmD  superfamilies and two superfamilies of predicted methylases defined  by the YbeA and MJ0421 proteins in bacteria and archaea,  respectively [1] (PFAM:PF00588 PFAM:PF01746). SPOUT is  structurally  distinct  compared to more classical methyltransferases [1]. More specifically, the members of this clan form alpha/beta knots. Knots are extremely rare in protein structures as they pose a\	folding problem. The mechanism that allow a domain to be folded as a knot are unclear, but are discussed in [2] and reference therein. All members with known structure form homodimers.	2008-09-03 15:50:29	2004-12-22 15:38:51	13	112	85	5028	32567	1
+99	CL0099	ALDH-like	\N	ALDH-like superfamily	Finn RD	anon	The aldehyde dehydrogenases (ALDHs) are a superfamily of multimeric  enzymes which catalyse the oxidation of a broad range of aldehydes into  their corresponding carboxylic acids with the reduction of their cofactor, NAD(P) into NAD(P)H.  The way that the NAD is bound is distinct from other NAD(P)-dependent oxidoreductases.  The domain represented by this  clan consists of two similar subdomains.	2008-09-03 15:50:29	2004-12-22 15:45:47	12	614	141	5455	48240	1
+100	CL0100	C1q_TNF	\N	C1q and TNF superfamily	Finn RD	anon	The members of the C1q and TNF superfamily are involved in a diverse set  of functions, which include: defense, inflammation, apoptosis, autoimmunity differentiation, organogenesis, hibernation and insulin-resistant\	obesity [1].  Both C1q and TNF domains form a compact jelly-roll beta- sandwich.  The core of these structures are conserved between the two families and corresponds to the detectable sequence similarity. Proteins containing both of these domains, form trimers before they are active.  However, the surfaces of the domains are quite different and  this difference is thought to give rise to the function difference between the clan members[1].  	2008-09-03 15:50:29	2004-12-22 15:46:56	12	294	48	443	3534	1
+101	CL0101	PELOTA	RNA_ribose_bind;	Pelota - RNA ribose binding superfamily	Finn RD	anon	The members of this clan are all involved in binding to ribose sugar of RNA[1].  Indeed, the key RNA binding residues are conserved across the different families [1].  Members of this clan form mixed alpha-helical and beta-sheet structures [1][2].	2012-10-06 18:35:16	2005-01-04 15:00:27	11	212	56	5002	13986	1
+103	CL0103	Gal_mutarotase	\N	Galactose Mutarotase-like superfamily	Bateman A	anon	This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.	2008-09-03 15:50:29	2005-01-28 16:18:34	11	539	313	4717	24927	1
+104	CL0104	Glyoxalase	\N	VOC superfamily	Bateman A	anon	This clan contains the VOC metalloenzyme superfamily [1]. The known types of reactions that are catalysed include isomerizations (glyoxalase I), epimerizations (methylmalonyl-CoA epimerase), oxidative cleavage of C-C bonds (extradiol dioxygenase), and nucleophilic substitutions (fosfomycin resistance proteins) [1].	2008-09-03 15:50:29	2005-01-28 18:11:34	12	363	157	4720	43346	1
+105	CL0105	Hybrid	\N	Barrel sandwich hybrid superfamily	Bateman A	anon	This superfamily contains proteins with a hybrid motif [1]. This motif is embedded in structurally diverse proteins.	2008-09-03 15:50:29	2005-01-31 16:15:18	12	394	669	6221	139176	1
+106	CL0106	6PGD_C	\N	6-phosphogluconate dehydrogenase C-terminal-like superfamily	Bateman A	anon	This helical domain is found associated with Rossmann domains.	2008-09-03 15:50:29	2005-01-31 18:34:00	12	232	123	5955	39015	1
+107	CL0107	KOW	\N	KOW domain	Bateman A	anon	This superfamily includes proteins involved in translation that have a KOW like SH3-fold.	2008-09-03 15:50:29	2005-03-18 14:03:54	11	584	79	6487	23716	1
+108	CL0108	Actin_ATPase	\N	Actin-like ATPase Superfamily	Finn RD	anon	The actin-like ATPase domain forms an alpha/beta canonical fold. The domain can be subdivided into 1A, 1B, 2A and 2B subdomains. Subdomains 1A and 1B share the same RNAseH-like fold (a five-stranded beta-sheet decorated by a number of alpha-helices). Domains 1A and 2A are conserved in all members of this superfamily, whereas domain 1B and 2B have a variable structure and are even missing from some homologues [1].  Within the actin-like ATPase domain the ATP-binding site is highly conserved. The phosphate part of the ATP is bound in a cleft between subdomains 1A and 2A, whereas the adenosine moiety is bound to residues from domains 2A and 2B[1].	2008-09-03 15:50:29	2005-03-22 09:34:28	15	1022	508	11461	141414	1
+109	CL0109	CDA		Cytidine deaminase-like (CDA) superfamily	Finn RD, Coin L, Iyer LM, Zhang D, Aravind L	anon	This clan contains both free nucleotide and nucleic acid deaminases that act on adenosine, cytosine, guanine and cytidine, and are  collectively known as the deaminase superfamily.  The conserved fold  consists of a three-layered alpha/beta/alpha structure with 3 helices  and 4 strands in the 2134 order [1,2].This superfamily is further  divided into two major divisions based on the presence of a  helix (helix-4) that renders the terminal strands (strands 4 and 5) either parallel to each other in its presence, or anti-parallel  in its absence [2]. Structurally, the deaminase-like fold is present in four other superfamilies including the JAB-like metalloproteins,  the C-terminal AICAR transformylase-catalyzing domains of PurH,  Tm1506 and the formate dehydrogenase accessory subunit FdhD. The active site of the deaminases is composed of three residues  that coordinate a zinc ion between conserved helices 2 and 3. The  residues are typically found as [HCD]xE and CxxC motifs at the  beginning of helices 2 and 3. The zinc ion activates a water  molecule, which forms a tetrahderal intermediate with the carbon  atom that is linked to the amine group. This is followed by  deamination of the base.  	2008-09-03 15:50:29	2005-03-22 09:57:40	11	208	1010	5319	27014	1
+110	CL0110	GT-A		Glycosyl transferase clan GT-A	Bateman A	anon	This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].	2008-09-03 15:50:29	2005-03-22 10:54:55	11	713	1496	7680	127750	1
+111	CL0111	GT-C		Glycosyl transferase GT-C superfamily	Bateman A	anon	This is the GT-C clan that contains diverse glycosyltransferases that possess 8-13 predicted transmembrane segments [1].	2008-09-03 15:50:29	2005-03-22 13:52:31	10	19	303	4345	19864	1
+112	CL0112	Yip1		Yip1/YIF1-like	Finn RD, Mistry J	anon	Yip1 and YIF1 are members of an integral membrane complex which bind to Ras-like GTPases and are required for membrane fusion of ER derived vesicles with the Golgi [1].	2008-09-03 15:50:29	2005-03-22 15:32:52	12	4	63	2706	5788	1
+113	CL0113	GT-B	\N	Glycosyl transferase clan GT-B	Bateman A	anon	This is the GT-B clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].	2008-09-03 15:50:29	2005-03-22 17:19:24	12	539	1601	8102	141567	1
+114	CL0114	HMG-box	\N	HMG-box like superfamily	Bateman A	anon	This clan includes the DNA-binding HMG-box proteins as well as the YABBY-like transcription factors.	2008-09-03 15:50:29	2005-03-23 13:44:43	11	62	241	1493	10953	1
+115	CL0115	Steroid_dh	\N	Steroid oxidoreductase superfamily	Bateman A	anon	This clan includes several enzymes, including steroid dehydrogenases and isoprenylcysteine carboxyl methyltransferase enzymes. These protein contain a varying number of transmembrane regions.	2008-09-03 15:50:29	2005-03-23 14:15:40	11	1	60	2542	7438	1
+116	CL0116	Calycin	\N	Calycin superfamily	Bateman A	anon	The calycin structural superfamily [1-3] includes the lipocalins, the fatty acid-binding proteins (FABPs).	2008-09-03 15:50:29	2005-03-23 14:57:38	12	662	102	3233	10920	1
+117	CL0117	uPAR_Ly6_toxin	\N	uPAR/Ly6/CD59/snake toxin-receptor superfamily	Bateman A	anon	This superfamily contains snake toxins as well as extracellular cysteine rich domains.	2008-09-03 15:50:29	2005-03-30 14:52:26	10	228	28	268	2910	1
+118	CL0118	Ribokinase	\N	Ribokinase-like superfamily	Bateman A	anon	All of these enzymes are phosphotransferases that have an alcohol group as an acceptor (EC:2.7.1.-). However, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMPP kinase) catalyses two phosphorylation reactions: one to a hydroxymethyl group of hydroxymethyl pyrimidine (HMP) and the second to the phosphomethyl group of HMPP [1]. The common structural feature for the enzymes in this superfamily is a central eight-stranded sheet that is flanked by eight structurally conserved helices, five on one side and three on the other [1]. The active site is located in a shallow groove along one edge of the sheet, with the phosphate acceptor hydroxyl group and -phosphate of ATP close together in the middle of the groove, and substrate and ATP binding at the ends [1].	2008-09-03 15:50:29	2005-04-01 13:48:37	11	400	155	5041	42135	1
+121	CL0121	Cystatin		Cystatin-like superfamily	Bateman A	anon	This superfamily includes cystatins and cathelicidins [1]. The cystatin superfamily comprises cysteine protease inhibitors that play key regulatory roles in protein degradation processes. The progenitor of this superfamily was most probably intracellular and lacked a signal peptide and disulfide bridges, much like the extant Giardia cystatin. A primordial gene duplication produced two ancestral eukaryotic lineages, cystatins and stefins. Stefins - included in Pfam:PF00031 - remain encoded by a single or a small number of genes throughout the eukaryotes, whereas the cystatins have undergone a more complex and dynamic evolution through numerous gene and domain duplications [2].	2008-09-03 15:50:29	2005-04-05 16:56:37	11	86	26	392	2322	1
+122	CL0122	UTRA	Chor_lyase;	Chorismate lyase/UTRA superfamily	Bateman A	anon	This clan includes chorismate lyase as well as the UTRA domain	2008-09-03 15:50:29	2005-04-05 17:05:44	10	71	33	3574	14169	1
+123	CL0123	HTH		Helix-turn-helix clan	Bateman A	anon	This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif.	2008-09-03 15:50:29	2005-04-05 17:52:07	17	2812	5699	10949	1020775	1
+124	CL0124	Peptidase_PA		Peptidase clan PA	Bateman A	anon	This clan contains a diverse set of peptidases with the trypsin fold.	2008-09-03 15:50:29	2005-04-06 15:44:18	14	2540	1159	7202	60527	1
+125	CL0125	Peptidase_CA		Peptidase clan CA	Bateman A	anon	This clan includes peptidases with the papain-like fold.	2008-09-03 15:50:29	2005-04-06 17:40:48	14	814	1796	6922	76571	1
+126	CL0126	Peptidase_MA		Peptidase clan MA	Bateman A	anon	Clan MA is one of two zinc-dependent metallopeptidases that contain the HEXXH motif.  The two histidines are zinc ligands. The structures of this clan show the active site is between its two sub-domains.	2008-09-03 15:50:29	2005-04-07 08:52:20	17	981	1676	6188	88418	1
+127	CL0127	ClpP_crotonase		ClpP/Crotonase superfamily	Bateman A	anon	This family includes several peptidases of peptidase clan SK as well as crotonase like proteins.	2008-09-03 15:50:29	2005-04-07 12:12:33	11	1093	331	8610	70137	1
+128	CL0128	vWA-like		von Willebrand factor type A	Finn RD	anon	To add.	2008-09-03 15:50:29	2005-04-07 17:59:38	11	223	1340	4970	35661	1
+129	CL0129	Peptidase_AA	\N	Peptidase clan AA	Bateman A	anon	This clan contains aspartic peptidases, including the pepsins and retropepsins. These enzymes contains a catalytic dyad composed of two aspartates. In the retropepsins one is provided by each copy of a homodimeric protein, whereas in the pepsin-like peptidases these aspartates come from a single protein composed of two duplicated domains.	2008-09-03 15:50:29	2005-04-08 09:36:39	13	1842	629	2629	138509	1
+130	CL0130	Peptidase_AD	\N	Peptidase clan AD	Bateman A	anon	Members of this clan are peptidases that are integral membrane proteins. The catalytic aspartate is in the conserved GXGD motif.	2008-09-03 15:50:29	2005-04-08 11:13:31	10	5	33	3841	6449	1
+131	CL0131	DoxD-like		DoxD-like	Mistry J	anon	The families in this clan are all membrane proteins.  The DoxD family is found on enzymes involved in elemental sulphur oxidation [1].  The other families in this clan are poorly characterised.	2008-09-03 15:50:29	2005-04-08 11:57:52	10	0	56	3235	10608	1
+132	CL0132	AbrB	\N	AbrB/MraZ DNA-binding domain	Bateman A	anon	This superfamily includes the DNA-binding domain of AbrB as well as the presumed DNA-binding protein MraZ (per. comm. A Andreeva and A Murzin).	2008-09-03 15:50:29	2005-04-08 13:53:50	12	50	24	3586	11690	1
+133	CL0133	AT14A-like	\N	AT14A-like	Mistry J	anon	This clan contains plant proteins.  DUF677 family members are AT14A-like proteins that have sequence similarity to fungal, insect and human integrins [1].  The other members of this clan are poorly characterised.	2008-09-03 15:50:29	2005-04-08 14:00:57	10	0	14	26	879	1
+135	CL0135	Arrestin_N-like	\N	Arrestin_N-like	Mistry J	anon	The families in this clan are involved in vacuolar protein trafficking, G protein signal termination and sporulation.  The Arrestin N terminal domain has an Ig-like beta sandwich fold which binds to receptors and impairs their capacity to active G proteins [1].  Arrestins have also been implicated in the endocytosis of receptors and cross talk with other signalling pathways [2].	2008-09-03 15:50:29	2005-04-12 14:27:53	10	34	59	768	5476	1
+136	CL0136	Plasmid_toxin	\N	Plasmid toxin-antitoxin system	Mistry J	anon	The families in this clan are plasmid encoded toxins involved in plasmid maintenance.  The plasmid encodes both a toxin and an antitoxin.  Upon loss of the plasmid the antitoxin is inactivated more rapidly than the toxin.  This allows the toxin to interact with its target thus killing the cell or impeding growth.	2008-09-03 15:50:29	2005-04-14 09:55:24	11	91	44	3558	18077	1
+137	CL0137	HAD		HAD superfamily	Bateman A	anon	This clan represents the haloacid dehalogenase (HAD) superfamily that includes a diverse range of enzymes that use an asp carboxylate as a nucleophile [1].	2008-09-03 15:50:29	2005-04-15 16:57:28	14	780	821	6664	120193	1
+139	CL0139	GADPH_aa-bio_dh	\N	Amino acid biosynthesis and glycosomal dehydrogenase	Mistry J	anon	This clan contains the C terminal domains of dehydrogenase enzymes involved in the biosynthesis of arginine, aspartate and aspartate derived amino acids.  It also contains the C terminal domain of GAPDH, a dehydrogenase involved in glycolysis and gluconeogenesis.	2008-09-03 15:50:29	2005-04-18 13:42:09	10	525	39	9289	24271	1
+140	CL0140	Viral_NABP	\N	Viral nucleic acid binding	Mistry J	anon	This clan contains viral nucleic acid binding protein families. Two of the families in this clan are known to contain zinc finger motifs [1][2].	2008-09-03 15:50:29	2005-04-18 14:24:28	10	0	5	71	578	1
+141	CL0141	MtN3-like		MtN3-like, vesicle-trafficking cargo-receptors	Mistry J	anon	The clan forms a large and diverse family of proteins with seven transmembrane helices, common topology and, most likely, similar function. Their coding genes exist in all eukaryota and in several prokaryota. Some are responsible for metabolic diseases (cystinosis, congenital disorder of glycosylation), others are candidate genes for genetic disorders (cleft lip and palate, certain forms of cancer) or solute uptake and efflux (SWEETs) and many have not yet been assigned a function. Comparison with the properties of well-annotated clan members suggests that the proteins could be involved in protein trafficking and serve as cargo receptors in vesicle trafficking [3].	2008-09-03 15:50:29	2005-04-19 09:24:39	11	0	74	1425	7738	1
+142	CL0142	Membrane_trans		Membrane and transport protein	Mistry J	anon	This clan contains membrane proteins involved in the transport of molecules including amino acids sugars and signalling molecules. It also includes integral membrane cell cycle proteins and some putative ammonia monooxygenases.	2008-09-03 15:50:29	2005-04-20 13:47:04	11	10	78	4928	72098	1
+143	CL0143	B_Fructosidase		Beta fructosidase superfamily	Mistry J	anon	This beta fructosidase superfamily [4] is composed of glycosyl hydrolase families.  The members of this clan adopt a five-bladed beta-propeller fold [2-3]. The beta-fructosidase superfamily is also known as furanosidase superfamily [4].	2008-09-03 15:50:29	2005-04-25 11:24:48	15	191	281	2992	11034	1
+144	CL0144	Periplas_BP	Periplas_BP-like;	Periplasmic binding protein like	Mistry J	anon	This clan includes proteins involved in chemotaxis, membrane transport of sugars and allocrites, and the LacI family transcriptional regulators.  It also includes some antigenic basic membrane lipoproteins.	2008-09-03 15:50:29	2005-04-25 15:04:24	12	462	379	4786	70533	1
+145	CL0145	Golgi-transport	\N	Golgi-transport	Mistry J	anon	This clan contains families that are involved in intracellular transport and signalling.\	\	    Arfaptins are proteins which interact with small GTPases involved in vesicular budding at the Golgi complex.  They form an elongated dimer of three helix coiled coils and are structurally very similar to the BAR domain [1][2]. The Sec34 family is involved in tethering vesicles to the Golgi [3].	2008-09-03 15:50:29	2005-04-25 16:18:47	14	49	165	766	6140	1
+146	CL0146	Herpes_glyco	\N	Herpes glycoprotein	Mistry J	anon	This clan contains herpes envelope glycoproteins [1][2].	2008-09-03 15:50:29	2005-04-25 16:48:44	11	0	3	78	288	1
+147	CL0147	Traffic	\N	Trafficking protein	Mistry J	anon	The members of this clan are involved in protein trafficking. The Sec20 family are integral membrane proteins involved in ER to Golgi transport [1] and V-SNARES are involved in membrane fusion [2].	2008-09-03 15:50:29	2005-04-26 10:46:36	10	7	29	336	2129	1
+148	CL0148	Viral_Gag	\N	Viral Gag protein	Mistry J	anon	This clan contains Gag proteins which are involved in viral assembly and replication [1][2].  	2008-09-03 15:50:29	2005-04-27 12:13:23	10	185	102	374	45347	1
+149	CL0149	CoA-acyltrans	\N	CoA-dependent acyltransferase superfamily	Finn RD	anon	All characterised families in this clan are involved in CoA-dependent acyltransferase. All families have a characteristic HXXXD motif.	2008-09-03 15:50:29	2005-04-27 14:03:23	11	193	1986	4892	38354	1
+151	CL0151	PK_TIM	\N	Pyruvate kinase-like TIM barrel superfamily	Bateman A	anon	This superfamily consists of a number of TIM barrel domains found in enzymes such as pyruvate kinase, malate synthase and citrate lyase.	2008-09-03 15:50:29	2005-05-03 14:40:00	11	507	138	6403	40855	1
+153	CL0153	dUTPase	\N	dUTPase like superfamily	Bateman A	anon	This clan contains dUTPase and many viral proteins that appear to be related. dUTPases are important in virus replication.	2008-09-03 15:50:29	2005-05-04 09:16:52	10	268	42	4817	8241	1
+154	CL0154	C2		C2 superfamily	Bateman A	anon	This superfamily includes C2 domains and C2-like domains.	2008-09-03 15:50:29	2005-05-04 15:46:49	10	222	791	571	27805	1
+155	CL0155	CBM_14_19	\N	Carbohydrate binding domain 14/19 clan	Bateman A	anon	This clan includes two different carbohydrate binding modules.	2008-09-03 15:50:29	2005-05-04 15:50:34	10	1	158	335	6959	1
+156	CL0156	Nucleocapsid	\N	Mononegaviral nucleocapsid superfamily	Bateman A	anon	This clan contains paramyxoviral and ebola type virus nucleocapsid proteins.	2008-09-03 15:50:29	2005-05-04 16:11:33	10	4	2	470	5978	1
+157	CL0157	Kleisin	\N	Kleisin superfamily	Bateman A	anon	The kleisin superfamily includes ScpA, Scc1, Rec8, and Barren [1]. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure [1].	2008-09-03 15:50:29	2005-05-04 16:26:02	10	4	11	3187	3510	1
+158	CL0158	GH_CE	\N	Glycoside hydrolase/deacetylase superfamily	Bateman A	anon	This superfamily contains diverse enzymes that act on carbohydrates including both hydrolases and deacetylases.	2008-09-03 15:50:29	2005-05-04 16:44:41	11	125	249	4786	20178	1
+159	CL0159	E-set		Ig-like fold superfamily (E-set)	Finn RD, Bateman A	anon	This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.	2008-12-15 16:59:57	2005-05-09 16:19:14	15	1072	9593	6497	213896	1
+160	CL0160	Methionine_synt		Cobalamin-independent synthase	Finn RD	anon	The N-terminal and C-terminal cobalamin-independent synthase domains are structurally similar, adopting a TIM beta/alpha barrel. However, the two domain perform functionally different roles. The N-terminal domain and C-terminal domains both define a catalytic cleft in the enzyme.  The N-terminal domain is thought to bind the substrate, in particular, the negatively charged polyglutamate chain.  The N-terminal domain is also thought to stabilise a loop from the C-terminal domain. The C-terminal domain contains the active site residues[1].	2008-09-03 15:50:29	2005-05-09 16:58:23	10	56	28	4455	12453	1
+161	CL0161	GAF	\N	GAF domain-like	Finn RD	anon	A clan of related transcriptional regulator domains.	2008-09-03 15:50:29	2005-05-09 18:32:14	11	220	3047	6850	47618	1
+162	CL0162	FBA	\N	F-box associated	Finn RD	anon	Clan containing related F-box associated families.	2008-09-03 15:50:29	2005-05-09 18:41:19	10	0	47	50	1557	1
+163	CL0163	Calcineurin		Calcineurin-like phosphoesterase superfamily	Bateman A	anon	This clan contains the calcineurin-like phosphoesterases. This clan also includes the apparently inactive homologues from the small DNA polymerase subunits [1].	2008-09-03 15:50:29	2005-05-10 16:59:39	10	274	576	5495	51255	1
+164	CL0164	CUB	\N	CUB clan	Bateman A	anon	This clan contains the CUB domain [1,2].	2008-09-03 15:50:29	2005-05-10 17:23:26	12	31	892	190	13225	1
+165	CL0165	Cache	\N	Cache-like domain	Finn RD	anon	The Cache domain an extracellular domain that is thought to have a role in small-molecule recognition in a wide range of proteins, including the animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors [1].	2008-09-03 15:50:29	2005-05-10 17:26:33	10	40	407	2883	12801	1
+166	CL0166	PRD	\N	PRD domain superfamily	Bateman A	anon	The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator of the BglG family as well as in activators such as MtlR and LevR. The PRD domain is phosphorylated on a conserved histidine residue. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators (Pfam:PF03123, see also comments for this family)) or DNA (for activators), and a duplicated PRD module which is phosphorylated on conserved histidines by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations are thought to modify the stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain.	2008-09-03 15:50:29	2005-05-11 14:46:29	11	9	110	2060	16551	1
+167	CL0167	Zn_Beta_Ribbon		Zinc beta-ribbon	Finn RD	anon	A clan of zinc-binding ribbon domains.	2008-09-03 15:50:29	2005-05-11 16:19:40	14	628	1382	6834	87461	1
+168	CL0168	PAN	\N	PAN-like	Finn RD	anon	PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions [1].  These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs.	2008-09-03 15:50:29	2005-05-11 16:56:50	14	59	399	404	5383	1
+169	CL0169	Rep	\N	Rep-like domain	Bateman A	anon	This clan includes replication proteins for viruses and plasmids. This domain is known to bind DNA. The members of this clan have three motifs.  The central HXH is conserved in most families in the clan.	2008-09-03 15:50:29	2005-05-13 18:23:32	10	25	62	3938	11895	1
+170	CL0170	Peptidase_MD	\N	Peptidase MD	Finn RD	anon	This clan is comprised of carboxypeptidases and the N-terminal domain from Sonic hedgehog proteins.  The structure of the latter is similar to the peptidases, but the N-terminal domain of hedgehog has been demonstrate not to be involved in peptidase activity, but is more likely involved in signal transduction [1].	2008-09-03 15:50:29	2005-05-19 09:30:19	10	53	142	3407	9216	1
+171	CL0171	Phospoesterase	\N	inositol polyphosphate 1 phosphatase like superfamily	Bateman A	anon	Members of this clan show metal-dependent / lithium sensitive phosphomonoesterase activity. The clan includes inositol polyphosphate 1 phosphatase and fructose 1,6-bisphosphatase [1]. 	2008-09-03 15:50:29	2005-05-19 17:12:45	10	289	56	4585	15156	1
+172	CL0172	Thioredoxin	Thioredoxin-like;	Thioredoxin-like	Mistry J	anon	This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.	2008-09-03 15:50:29	2005-05-20 15:54:37	16	2327	1079	7198	142836	1
+173	CL0173	STIR	\N	STIR superfamily	Fenech M	anon	Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus [1].	2008-09-03 15:50:29	2005-08-11 10:18:06	10	27	1046	1412	7537	1
+174	CL0174	TetR_C	\N	TetR protein, C-terminal domain-like	Fenech M	anon	This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].	2008-09-03 15:50:29	2005-08-11 10:47:22	9	244	37	2464	10523	1
+175	CL0175	TRASH		TRASH superfamily	Fenech M	anon	TRASH-like domains contain well-conserved cysteine residues that are thought to be involved in metal coordination. These domains are thus expected to be involved in metal trafficking and heavy-metal resistance. It has been suggested that the members adopt a 'treble-clef' fold, with 3/4 beta strands preceding a C-terminal alpha helix [1].	2008-09-03 15:50:29	2005-08-15 13:59:13	10	149	389	2803	12513	1
+176	CL0176	Chemosens_recp	\N	Chemosensory 7tm receptor superfamily	Finn R, Fenech M	anon	The members of this clan are families of various gustatory and odorant receptors. They are described as being seven-transmembrane receptors, and in fact all show characteristic regions of hydrophobicity on the alignment.	2008-09-03 15:50:29	2005-08-15 14:20:45	9	0	50	129	5871	1
+177	CL0177	PBP	\N	Periplasmic binding protein clan	Bateman A	anon	Periplasmic binding proteins (PBPs) consist of two large lobes that close around the bound ligand. This architecture is reiterated in transcriptional regulators, such as the lac repressors. In the process of evolution, genes encoding the PBPs have fused with genes for integral membrane proteins. Thus, diverse mammalian receptors contain extracellular ligand binding domains that are homologous to the PBPs; these include glutamate/glycine-gated ion channels such as the NMDA receptor, G protein-coupled receptors, including metabotropic glutamate, GABA-B, calcium sensing, and pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors [2].	2008-09-03 15:50:29	2005-08-22 13:15:50	15	1664	837	5964	242652	1
+178	CL0178	PUA	\N	PUA/ASCH superfamily	Bateman A	anon	This clan consists of the RNA binding PUA domain and ASCH domain. It also contains uncharacterised protein families.	2008-09-03 15:50:29	2005-08-22 16:11:13	15	169	216	5007	19669	1
+179	CL0179	ATP-grasp	\N	ATP-grasp superfamily	Bateman A	anon	The ATP-grasp domain is found in a wide variety of carboxylate-amine/thiol ligases [1]. It is composed of two subdomains, with ATP being bound in the cleft between the two.	2008-09-03 15:50:29	2005-08-23 14:07:58	13	397	518	7468	61819	1
+181	CL0181	ABC-2	\N	ABC-2-transporter-like clan	Fenech M	anon	These families are similar to the ABC-2 transporter subfamily, as described in [1] (Pfam:PF01061). Members of this family are involved in drug transport and resistance. CcmB protein family (Pfam:PF03379) members are also transporters; they are required for haem export into the periplasm [2].	2008-09-03 15:50:29	2005-08-23 16:06:40	9	3	239	5481	49701	1
+182	CL0182	IT	\N	IT (Ion Transporter) superfamily	Bateman A	anon	This superfamily of secondary carriers specific for cationic and anionic compounds, has been termed the ion transporter (IT) superfamily [1].	2008-09-03 15:50:29	2005-08-23 18:40:04	12	0	126	4842	49966	1
+183	CL0183	PAS_Fold	PAS;	PAS domain clan	Bateman A	anon	This clan contains PAS domains that are found in a wide variety of bacterial signaling proteins.	2008-09-03 15:50:29	2005-08-24 15:20:49	13	311	6949	5998	88093	1
+184	CL0184	DMT		Drug/Metabolite transporter superfamily	Bateman A	anon	This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1].  Many of these families contain a characteristic glycine rich motif close to the C-terminus.	2008-09-03 15:50:29	2005-08-25 11:36:38	10	12	341	5620	114318	1
+186	CL0186	Beta_propeller		Beta propeller clan	Bateman A	anon	This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled.  The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.	2008-09-03 15:50:29	2005-08-26 09:32:54	13	1163	8240	11212	356413	1
+187	CL0187	LysM	\N	LysM-like domain	Fenech M	anon	The LysM domain (Pfam:PF01476) is thought to be a general peptidoglycan-binding module. Although originally described in bacterial proteins, it has been also found in some eukaryotic sequences. It takes up a beta-alpha-alpha-beta conformation, with the beta strands forming an antiparallel beta sheet and the two alpha helices packing on one side of this sheet [1].	2008-09-03 15:50:29	2005-08-26 09:44:43	10	8	614	4599	29820	1
+188	CL0188	CH	\N	Calponin homology domain	Fenech M	anon	The calponin homology (CH) domain is found in a variety of contexts, ranging from proteins involved in signalling pathways to cytoskeletal proteins. They seem to have diverse cellular functions, which are thought to include actin binding, involvement in the MAP kinase signalling pathway, and regulation of GEF activity in Rho family GTPase pathways. Structurally, they are organised into three layers, with two parallel alpha helices in the core being sandwiched between another two helices, one on each side [1].	2008-09-03 15:50:29	2005-08-30 18:32:49	9	107	636	512	11687	1
+189	CL0189	Endonuclease	\N	Endonuclease V-like superfamily	Wuster A	anon	This clan contains DNA repair proteins.  In E. coli endonuclease V initiates DNA repair of deaminated DNA bases and has similarity to motifs required for the catalytic activity of the UvrC endonuclease [1].	2008-09-03 15:50:29	2005-08-31 14:14:38	9	20	27	4568	5628	1
+190	CL0190	HSP20		HSP20-like chaperone superfamily	Fenech M	anon	The small heat shock proteins (sHSPs) prevent protein aggregation during heat shock and oppose regulated cell death. A conserved arginine residue in the HSP20/alpha-crystallin domain (Pfam:PF00011) has in fact been implicated in the development of cataracts and myopathies [1]. The CS family (Pfam:PF04969) includes proteins that are known to bind HSP90 [2], as well as p23 (Swiss:Q15185), which is an HSP90 co-chaperone [3].	2008-09-03 15:50:29	2005-09-01 14:25:02	11	201	170	4085	13158	1
+191	CL0191	POTRA	\N	POTRA domain superfamily	Fenech M	anon	The polypeptide-transport-associated (POTRA) domain is predicted to be organised into three beta-strands and two alpha helices, the latter being found between strands 2 and 3. It is usually found associated with a beta-barrel outer membrane domain. It is thought to have a chaperone-like function; the proteins it is found in are involved in processes as diverse as bacterial septation and protein transport across membranes [1].	2008-09-03 15:50:29	2005-09-01 14:31:22	10	20	53	4354	20069	1
+192	CL0192	GPCR_A		Family A G protein-coupled receptor-like superfamily	Fenech M	anon	This clan contains various seven-transmembrane receptors and related proteins. A major member is Pfam:PF00001, members of which have been considered to be typical members of the rhodopsin superfamily. Many members of this clan are Caenorhabditis proteins, suggesting great expansion of the relevant families in these nematode worms.	2008-09-03 15:50:29	2005-09-02 12:58:56	12	304	924	9484	92105	1
+193	CL0193	MBB		Outer membrane beta-barrel protein superfamily	Bateman A	anon	This clan gathers together a large set of beta barrel membrane proteins.Although these proteins have different numbers of beta strands in the barrel they have significant sequence similarity between families.	2008-09-03 15:50:29	2005-09-05 10:13:31	13	356	515	4665	118601	1
+194	CL0194	DNA_pol_B-like	\N	DNA polymerase B like	Mistry J	anon	DNA polymerases replicate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of a growing chain of DNA.  They use a complementary DNA chain as a template.`	2008-09-03 15:50:29	2005-09-05 13:42:41	9	181	97	2623	7651	1
+195	CL0195	DBL	\N	Duff-binding like superfamily	Bateman A	anon	This clan includes DBL (Duffy-binding like) domains from a variety of plasmodium surface proteins.	2008-09-03 15:50:29	2005-09-05 15:25:46	9	4	55	9	832	1
+196	CL0196	DSRM	\N	DSRM-like clan	Bateman A	anon	This clan contains RNA-binding domains.	2008-09-03 15:50:29	2005-09-08 18:03:50	11	267	170	5456	15069	1
+197	CL0197	GME	\N	GME superfamily	Bateman A, Shirai H	anon	This superfamily contains a number of related enzymes such as AstB, peptidyl-arginine deiminase, arginine deiminase and amidinotransferase [1,2].	2008-09-03 15:50:29	2005-09-15 15:15:35	9	117	27	3437	6472	1
+198	CL0198	HHH		Helix-hairpin-helix superfamily	Bateman A	anon	This superfamily includes Helix-hairpin-helix DNA-binding domains.	2008-09-03 15:50:29	2005-09-16 17:04:15	15	655	587	6368	81507	1
+199	CL0199	DPBB	\N	Double Psi beta barrel glucanase	Bateman A	anon	The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions [1,2]. This clan represents the barwin like barrels.	2008-09-03 15:50:29	2005-09-16 17:23:52	11	29	104	3343	9071	1
+200	CL0200	Prefoldin	\N	Prefoldin	GriffithsJones S, Finn RD, Mistry J	anon	The Prefoldin domain forms a coiled-coil structure that is involved in substrate-binding in the the chaperone co-factor prefoldin (PFD).  Each PFD is assembled from two alpha and four beta subunits. Each alpha subunit contains two, and each beta subunit one, central beta-hairpin that is flanked N- and C-terminally by coiled-coil helices. The N-terminal regions, the prefoldin domain, are found facing into the central cavity of the chaperone. Here exposed hydrophobic patches form an interaction with the substrate (an unfolded protein) [1].	2008-09-03 15:50:29	2005-09-19 13:51:59	9	9	52	526	2970	1
+201	CL0201	Peptidase_SH	\N	Peptidase clan SH	Bateman A	anon	This clan includes the serine peptidase assemblin from herpes virus as well as other viral peptidase families predicted to be related [1].	2008-09-03 15:50:29	2005-09-20 12:38:50	9	47	16	1555	2100	1
+202	CL0202	GBD		Galactose-binding domain-like superfamily	Bateman A	anon	This large superfamily contains beta sandwich domains with a jelly roll topology. Many of these families are involved in carbohydrate recognition. Despite sharing little sequence similarity they do share a weak sequence motif, with a conserved bulge in the C-terminal beta sheet. The probable role of this bulge is in bending of the beta sheet that contains the bulge. This enables the curvature of the sheet forming the sugar binding site [1].	2008-09-03 15:50:29	2005-09-20 16:50:13	10	807	2917	4159	38880	1
+203	CL0203	CBD	\N	Carbohydrate binding domain superfamily	Bateman A	anon	This superfamily includes several carbohydrate binding domains. These domains have a beta sandwich structure.	2008-09-03 15:50:29	2005-09-21 11:02:43	11	97	423	950	3904	1
+204	CL0204	Adhesin	\N	Bacterial adhesin superfamily	Bateman A	anon	This superfamily includes a variety of bacterial adhesins that have a jelly-roll beta-barrel fold [1]. These domains are involved in sugar recognition.	2008-09-03 15:50:29	2005-09-21 11:17:50	10	156	136	1489	19890	1
+205	CL0205	Di-copper	\N	Di-copper centre-containing domain	Bateman A	anon	This superfamily includes tyrosinases and hemocyanins that share a di-copper centre [1].	2008-09-03 15:50:29	2005-09-23 12:59:27	10	106	90	1801	4482	1
+206	CL0206	TRB	\N	Transcriptional repressor beta-barrel domain	Bateman A	anon	This beta-barrel domain is found at the C-terminus of a variety of transcriptional repressor proteins.	2008-09-03 15:50:29	2005-09-23 14:02:56	10	132	32	4239	8501	1
+207	CL0207	Rhomboid-like	\N	Integral membrane protein / protease	Mistry J	anon	This clan contains proteins from both bacteria and eukaryotes. The Rhomboid protein is an intramembrane serine protease which is involved in epidermal growth factor (EGF)-dependent signalling pathways [1]. The DER1 family is involved in degradation of misfolded ER proteins [2].	2008-09-03 15:50:29	2005-12-01 11:27:30	9	16	91	4052	9025	1
+208	CL0208	UBC	\N	Ubiquitin conjugating enzyme like superfamily	Bateman A	anon	This superfamily includes a diverse set of proteins that bind to ubiquitin [1].	2008-09-03 15:50:29	2005-12-02 15:22:57	10	294	238	870	12063	1
+209	CL0209	Bet_V_1_like	\N	Bet V 1 like	Mistry J	anon	The Bet_V_I family is composed of sequences related to the major Birch (Betula verrucose) pollen antigen Betv1.  This allergen is known to cause hayfever, dermatitis, asthma and occasionally anaphylactic shock.  The other families in this clan share the same structure as Betv1 which is composed of antiparallel beta sheets and alpha helices.  There is a cavity between the beta sheet and a long C terminal helix.  The cavity appears to play roles in the binding of lipid molecules [1][2][3] which seems a common feature of the families in this clan.	2008-11-07 17:26:25	2005-12-02 17:50:32	10	443	245	4418	23609	1
+210	CL0210	HNOX-like	\N	Heme NO and oxygen binding like	Mistry J	anon	This clan contains families that bind small molecules and are predominantly involved in signalling.  Members include the heme NO binding domain.  This domain is related to soluble guanylate cyclases and is mainly alpha helical in structure.\	      Other members of this clan include V4R, which is predicted to be a small molecule binding domain, and a domain often found adjacent to this that is found on activators of aromatic catabolism, and on signalling molecules.	2008-09-03 15:50:29	2005-12-06 09:55:10	10	54	47	793	1692	1
+212	CL0212	SNARE	\N	SNARE-like superfamily	Bateman A	anon	This clan includes part of the SNARE like superfamily.	2008-09-03 15:50:29	2005-12-08 17:07:43	8	44	96	372	5553	1
+213	CL0213	ShK-like	\N	Sea anemone toxin k like	Mistry J	anon	Members of this clan include the Crisp domain which is involved in ryanodine receptor Ca2+ signalling, and the ShK domain which is named after the ShK channel inhibitor toxin.  Both domains are cysteine rich and contain multiple disulphide bonds [1][2][3].	2008-09-03 15:50:29	2006-01-03 16:32:02	8	27	121	194	2516	1
+214	CL0214	UBA	\N	UBA superfamily	Bateman A	anon	This superfamily includes domains related to the UBA domain. These domains are often involved in ubiquitin binding.	2008-09-03 15:50:29	2006-01-05 15:54:42	12	148	350	5009	18121	1
+217	CL0217	Rotavirus_VP7	\N	Rotavirus VP7 protein	Bateman A	anon	This clan consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer [1].	2008-09-03 15:50:29	2006-01-24 14:08:46	8	28	2	702	4849	1
+218	CL0218	ox_reductase_C	\N	Oxidoreductase C terminal like	Mistry J	anon	This clan contains the C terminal region of oxidoreductase proteins and putative oxidoreductase proteins.  Families in this clan form an alpha/beta structure and are usually found adjacent to an N terminal Rossman fold.	2008-09-03 15:50:29	2006-01-26 11:16:09	11	193	37	3633	12363	1
+219	CL0219	RNase_H	\N	Ribonuclease H-like superfamily	Bateman A	anon	This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H.	2008-09-03 15:50:29	2006-01-31 17:56:29	13	1007	2352	7614	190937	1
+220	CL0220	EF_hand	\N	EF-hand like superfamily	Bateman A	anon	The EF hand is a calcium binding domain found in a wide variety of proteins [1].	2008-09-03 15:50:29	2006-02-01 09:23:33	11	1170	2215	3113	56360	1
+221	CL0221	RRM	\N	RRM-like clan	Bateman A	anon	This clan contains families that are related to the RNA recognition motif domains.  However, not all these families are RNA binding.	2008-09-03 15:50:29	2006-03-05 12:30:44	10	736	1162	5818	73704	1
+222	CL0222	MviN_MATE	\N	MviN, MATE-like superfamily	Bateman A	anon	This superfamily consists of a variety of integral membrane protein families. The MATE family are known to be transporters. Other proteins have been implicated in virulence and polysaccharide biosynthesis.	2008-09-03 15:50:29	2006-03-05 13:21:19	7	4	109	5014	53746	1
+223	CL0223	MACRO	\N	MACRO domain superfamily	Bateman A	anon	This superfamily includes the Macro domain as well as the amino terminal domain from peptidase M17 proteins.	2008-09-03 15:50:29	2006-03-06 10:58:15	7	147	130	4353	8980	1
+224	CL0224	DHQS	\N	Dehydroquinate synthase-like superfamily	Bateman A	anon	This superfamily includes Dehydroquinate synthase and Iron containing alcohol dehydrogenase which have a similar active site organisation [1].	2008-09-03 15:50:29	2006-03-06 13:57:58	7	116	47	4875	18804	1
+225	CL0225	FtsL	\N	FtsL-like superfamily	Bateman A	anon	This clan includes two proteins that are known to interact, FtsL and DivIC which are part of a trimeric complex with DivIB [2]. DivIC and FtsL are bacterial proteins essential for cell division.	2008-09-03 15:50:29	2006-03-06 15:46:31	7	0	9	3920	6384	1
+226	CL0226	M6PR	\N	Mannose 6-phosphate receptor	Bateman A	anon	This clan includes cation dependent and independent mannose 6-phosphate receptors.	2008-09-03 15:50:29	2006-03-06 16:32:14	8	48	95	319	2892	1
+227	CL0227	Enolase_N	\N	Enolase N-terminal domain-like superfamily	Bateman A	anon	This domain is found at the N-terminus of the catalytic Tim barrel-like domain in enolase and other enzymes.	2008-09-03 15:50:29	2006-03-06 16:37:34	8	887	42	5636	14408	1
+228	CL0228	Acyltransferase		Acyltransferase clan	Bateman A	anon	This clan includes several families of related acyltransferases.	2008-09-03 15:50:29	2006-03-06 16:43:34	7	2	169	4885	24321	1
+229	CL0229	RING	\N	Ring-finger/U-box superfamily	Bateman A	anon	This clan includes the Ring zinc finger domains as well as the U-box domain that appears to have lost the zinc coordinating cysteine residues [1].	2008-09-03 15:50:29	2006-03-06 16:54:46	10	159	1983	4407	49901	1
+230	CL0230	HO	\N	Heme oxygenase-like superfamily	Bateman A	anon	This clan includes the Heme oxygenase family as well as the TENA/THI-4/PQQC family that are less well characterised [2].	2008-09-03 15:50:29	2006-03-06 16:57:26	7	195	41	2847	5166	1
+231	CL0231	MazG	\N	all-alpha NTP pyrophosphohydrolase superfamily	Bateman A	anon	This superfamily includes MazG, HisE and dimeric dUTPases (Not yet in Pfam) [1].	2008-09-03 15:50:29	2006-03-06 17:03:44	8	112	46	4768	13122	1
+232	CL0232	NifU	\N	NifU C-terminal domain-like superfamily	Bateman A	anon	This clan includes the C-terminal domain of NifU as well as a large family of uncharacterised domains.	2008-09-03 15:50:29	2006-03-06 17:10:22	7	28	49	4450	9837	1
+233	CL0233	SufE_NifU	\N	SufE/NifU superfamily	Bateman A	anon	This clan includes iron sulfur cluster assembly proteins.	2008-09-03 15:50:29	2006-03-06 17:18:24	7	30	26	4741	7304	1
+234	CL0234	CTPT	\N	CTP transferase-like superfamily	Bateman A	anon	This clan includes the integral membrane CTP transferase family as well as a large family of uncharacterised proteins that may also function as nucleotidyltransferases.	2008-09-03 15:50:29	2006-03-06 17:30:58	7	0	20	4821	6518	1
+235	CL0235	PspA	\N	PspA/ESCRT-III	Bateman A	anon	This clan includes PspA like proteins that are transcriptional activators as well as Snf7, a protein involved in cellular trafficking.	2008-09-03 15:50:29	2006-03-07 09:10:43	8	24	36	2194	5578	1
+236	CL0236	PDDEXK		PD-(D/E)XK nuclease superfamily	Bateman A	anon	This clan includes a large number of nuclease families related  to holliday junction resolvases [1,2].	2012-10-03 14:09:06	2006-03-07 10:09:50	16	584	895	6041	71985	1
+237	CL0237	HD_PDEase	\N	HD/PDEase superfamily	Bateman A	anon	This clan includes a range of phosphohydrolase enzymes with a common helical fold.	2008-09-03 15:50:29	2006-03-07 17:08:35	7	446	682	5155	45938	1
+238	CL0238	PP2C	\N	PP2C-like superfamily	Bateman A	anon	This clan includes the PP2C family of phosphatases as well as the SpoIIE family.  This suggests SpoIIE proteins may also be phosphatases.	2008-09-03 15:50:29	2006-03-08 17:11:21	7	81	723	3947	17476	1
+239	CL0239	Insulin	\N	Insulin-like superfamily	Bateman A	anon	This superfamily includes the insulin like hormones.	2008-09-03 15:50:29	2006-03-09 13:10:30	7	895	8	341	1563	1
+240	CL0240	PFK	\N	PFK-like superfamily	Bateman A	anon	This clan includes two SCOP superfamilies. Strong similarities between NAD kinases, DAG kinase, sphingosine kinase and PFK have previously been shown[1].	2008-09-03 15:50:29	2006-03-09 16:35:37	7	146	173	5088	20115	1
+241	CL0241	ABC_membrane	\N	ABC transporter membrane domain clan	Bateman A	anon	This clan includes families that are the membrane components of ABC transporter complexes. In general these regions are composed of six transmembrane helices [1].	2008-09-03 15:50:29	2006-03-09 17:38:52	7	22	211	5258	54224	1
+242	CL0242	DNA_primase_lrg	\N	DNA primase large subunit like	Mistry J	anon	This clan contains the large subunit of archaeal and eukaryotic DNA primase, an enzyme which synthesises the oligoribonucleotide primers essential to DNA replication.  The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays a roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase [1].  The clan also contains the Lef-2 family, which is required for the expression of late genes.  There is some evidence to suggest that LEF2 binds to both DNA and the DNA primase small subunit LEF-1 [3].	2008-09-03 15:50:29	2006-04-21 14:57:17	8	11	11	506	609	1
+243	CL0243	AEP		Archaeo-eukaryotic primase	Mistry J	anon	This clan includes the small subunit of 2 and eukaryotic DNA primase, and primase-helicase proteins from bacteriophages and plasmids.  All known cellular life forms use primases to synthesis a short RNA primer which is extended during DNA replication by a polymerase.  Bacterial DNA primase adopts a different fold to archaeal and eukaryotic primases and belongs to a different superfamily.	2008-09-03 15:50:29	2006-04-24 16:40:55	9	21	52	1612	2766	1
+244	CL0244	PGBD	\N	PGBD superfamily	Bateman A	anon	This clan consists of small putative peptidoglycan binding domains composed of three alpha helices.	2008-09-03 15:50:29	2006-05-16 17:51:06	8	23	345	3348	11009	1
+245	CL0245	EDD	\N	EDD superfamily	Bateman A	anon	The EDD superfamily was identified as an evolutionarily conserved domain (EDD) common to three different folds: mannose transporter EIIA domain (EIIA-man), dihydroxyacetone kinase (Dak), and DegV [1]. Both Dak and EIIA-man perform similar phosphotransfer reactions, suggesting a phosphotransferase activity for the DegV-like family of proteins, whose function other than lipid binding revealed in the crystal structure remains unknown [1].	2008-09-03 15:50:29	2006-05-17 09:35:18	8	92	62	3559	18450	1
+246	CL0246	ISOCOT_Fold	NagB-like;	Isomerase,CoA transferase & Translation initiation factor Superfamily	Bateman A, Anantharaman V	anon	This superfamily contains a variety of enzymes and non-enzymatic  ligand binding domains.	2008-09-03 15:50:29	2006-05-17 13:20:27	7	279	161	5233	53370	1
+247	CL0247	2H	\N	2H phosphoesterase superfamily	Bateman A	anon	This clan includes a number of phosphoesterases that contain an internal duplication.	2008-09-03 15:50:29	2006-05-17 15:53:15	8	24	78	2901	4878	1
+248	CL0248	ParBc	\N	ParB-like superfamily	Bateman A	anon	This superfamily includes nucleases related to ParB as well as uncharacterised proteins.	2008-09-03 15:50:29	2006-06-02 16:12:35	7	28	97	4788	13574	1
+249	CL0249	Phage_tail_L	\N	Phage minor tail protein L clan	Bateman A	anon	This clan includes the phage minor tail protein L as well as a group of uncharacterised proteins that are also presumably phage components.	2008-09-03 15:50:29	2006-06-02 18:35:28	7	0	7	706	1564	1
+250	CL0250	GAD	\N	GAD domain superfamily	Bateman A	anon	This domain is found as an insert within aspartyl-tRNA synthetase as well as GatB proteins.	2008-09-03 15:50:29	2006-07-27 15:00:10	6	16	17	4522	4847	1
+251	CL0251	MORN	\N	MORN repeat	Mistry J	anon	The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).\	A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis as dynamic component of cell division apparatus [1].\	It has been hypothesised to function as a linker protein between certain membrane regions and the parasite's cytoskeleton [1].	2008-09-03 15:50:29	2006-07-31 12:59:47	7	27	334	1412	30871	1
+252	CL0252	NfeD-like	\N	NfeD like	Mistry J	anon	This clan includes the NfeD family which contains several proteins described as nodulation efficiency protein D (NfeD). The nfe genes (nfeA, nfeB, and nfeD) are involved in the nodulation efficiency and competitiveness of the Sinorhizobium meliloti strain GR4 on alfalfa roots [1]. The specific function the NfeD family is unknown although it is unlikely that NfeD is specifically involved in nodulation as the family contains several different archaeal and bacterial species most of which are not symbionts.	2008-09-03 15:50:29	2006-07-31 13:35:37	6	3	8	2902	4042	1
+254	CL0254	THDP-binding		Thiamin diphosphate-binding superfamily	Mistry J, Bateman A	anon	This clan includes pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases.	2008-09-03 15:50:29	2006-07-31 17:23:48	8	598	271	5650	93998	1
+255	CL0255	ATP_synthase		ATP synthase F0 subunit	Mistry J	anon	This clan contains subunits of the F0 complex of ATP-synthase. The F0 complex is the non-catalytic unit of ATPase and is involved in proton translocation across membranes.	2008-09-03 15:50:29	2006-08-01 13:45:46	8	29	78	10710	23627	1
+256	CL0256	Enolase_TIM	\N	Enolase like TIM barrel	Mistry J	anon	This clan contains enzymes which adopt a TIM barrel fold.	2008-09-03 15:50:29	2006-08-01 15:00:35	6	1004	67	6025	21543	1
+257	CL0257	Acetyltrans	Acetyltrans-like;	N-acetyltransferase like	Mistry J	anon	This clan contains families related to N-acetyltransferases. N-acetyltransferases catalyse the transfer of acetyl groups from acetyl-CoA to arylamines.	2008-09-03 15:50:29	2006-08-02 14:16:08	8	664	967	6524	128815	1
+258	CL0258	DALR	\N	DALR superfamily	Bateman A	anon	Members of this family are anticodon binding domains from various tRNA synthetases.	2008-09-03 15:50:29	2006-08-17 18:00:51	6	13	28	4898	11747	1
+259	CL0259	OstA	\N	OstA superfamily	Bateman A	anon	This superfamily includes the OstA family as well as a large family of uncharacterised proteins.	2008-09-03 15:50:29	2006-08-22 10:05:45	6	11	32	2407	6093	1
+260	CL0260	NTP_transf	\N	Nucleotidyltransferase superfamily	Bateman A	anon	This clan contains a diverse set of nucleotidyltransferase enzymes.	2008-09-03 15:50:29	2006-08-22 16:46:46	7	338	577	5508	42917	1
+261	CL0261	NUDIX		NUDIX superfamily	Bateman A	anon	This superfamily contains the NUDIX family and one related family.	2008-09-03 15:50:29	2006-08-24 18:58:30	6	360	321	5236	48986	1
+262	CL0262	Trigger_C	\N	Trigger factor/SurA domain	Bateman A	anon	This helical domain is found in two families of chaperones.  It is found at the N terminus of the SurA proteins and at the C-terminus of the trigger factors where presumably it shares a common but as yet unknown function.	2008-09-03 15:50:29	2006-08-30 10:54:44	6	20	54	4464	9322	1
+263	CL0263	His-Me_finger		His-Me finger endonuclease superfamily	Bateman A	anon	This superfamily defined originally by SCOP contains a diverse range of endonucleases. Later Grishin identified the MH1 domain as belonging to the superfamily [1].	2008-09-03 15:50:29	2006-09-06 17:41:01	7	141	462	5328	22334	1
+264	CL0264	SGNH_hydrolase	\N	SGNH hydrolase superfamily	Bateman A	anon	This superfamily contains a diversity of hydrolytic enzyme activities.	2008-09-03 15:50:29	2006-09-07 09:23:58	6	122	427	4610	21200	1
+265	CL0265	HIT	\N	HIT superfamily	Bateman A	anon	The HIT superfamily are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides [1].	2008-09-03 15:50:29	2006-11-09 16:05:44	6	147	99	4930	15333	1
+266	CL0266	PH	\N	PH domain-like superfamily	Bateman A	anon	Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.	2008-09-03 15:50:29	2006-11-10 10:42:30	8	419	1526	2586	41992	1
+267	CL0267	S11_L18p	\N	Ribosomal protein S11/L18p superfamily	Bateman A	anon	This superfamily includes two ribosomal proteins S11 and L18p as well as a domain from eukaryotic peptide chain release factor. This superfamily is likely to share an RNA-binding function.	2008-09-03 15:50:29	2006-11-10 14:46:27	7	451	37	5925	12981	1
+268	CL0268	Pec_lyase-like	Pec_lyase; Pectate_lyase;	Pectate lyase-like beta helix	Bateman A	anon	This superfamily all contain a right handed beta helix similar to that first found in pectate lyase [1].	2008-09-03 15:50:29	2006-11-10 15:10:57	6	217	1681	4399	45644	1
+269	CL0269	Maf	\N	Maf/Ham1 superfamily	Bateman A	anon	This superfamily includes the Maf-like proteins and ITPases related to YjjX [1].	2008-09-03 15:50:29	2006-11-10 17:10:08	7	21	29	3802	6399	1
+270	CL0270	Iso_DH	\N	Isocitrate/Isopropylmalate dehydrogenase-like superfamily	Bateman A	anon	This superfamily of enzymes form dimers and have an active site between the two halves.	2008-09-03 15:50:29	2006-11-10 17:50:17	6	323	67	6496	27220	1
+271	CL0271	F-box	\N	F-box-like domain	Bateman A	anon	This clan includes classical F-boxes and the PRANC domain found in pox ankyrin proteins.	2008-09-03 15:50:29	2006-11-22 13:28:07	6	29	805	512	18595	1
+272	CL0272	RGS	\N	RGS-like superfamily	Bateman A	anon	This clan includes RGS domains that possess an alpha helical fold.	2008-09-03 15:50:29	2006-11-27 17:23:03	6	92	152	303	4401	1
+273	CL0273	CYTH	\N	CYTH-like phosphatase superfamily	Bateman A	anon	CyaB like adenylyl cyclase and the mammalian thiamine triphosphatases define a novel superfamily of catalytic domains called the CYTH domain that is present in all three superkingdoms of life. The catalytic core of these enzymes contain a novel alpha beta scaffold with 6 conserved acidic residues and 4 basic residues [1].	2008-09-03 15:50:29	2006-12-05 13:50:23	6	48	23	3410	3949	1
+274	CL0274	WRKY-GCM1	\N	WRKY-GCM1 superfamily	Bateman A	anon	WRKY and GCM1 are metal chelating DNA-binding domains (DBD) which share a four stranded fold [1]. We present evidence that they share a stabilising core, which suggests a possible origin from a BED finger-like intermediate that was in turn ultimately derived from a C2H2 Zn-finger domain [1].	2008-09-03 15:50:29	2006-12-05 13:57:43	7	5	215	443	6439	1
+275	CL0275	HAS-barrel	\N	HAS-barrel superfamily	Bateman A	anon	The HAS barrel is named after HerA-ATP Synthase. In ATP synthases, this domain is implicated in the assembly of the catalytic toroid and docking of accessory subunits, such as the subunit of the ATP synthase complex. Similar roles in docking of the functional partner, the NurA nuclease, and assembly of the HerA toroid complex appear likely for the HAS-barrel of the HerA family [1].	2008-09-03 15:50:29	2006-12-06 11:13:24	8	401	41	11124	22310	1
+276	CL0276	Nucleot_cyclase	\N	Nucleotide cyclase superfamily	Bateman A	anon	This superfamily includes adenylyl cyclase and the GGDEF domain [1].	2008-09-03 15:50:29	2006-12-06 14:41:38	7	119	2538	3679	52683	1
+277	CL0277	FAD-oxidase_C	\N	FAD-linked oxidase C-terminal domain superfamily	Bateman A	anon	This clan consists of a duplicated subdomain in a variety of FAD-liked oxidase/dehydrogenase enzymes.	2008-09-03 15:50:29	2006-12-07 10:48:02	6	129	128	3530	14475	1
+278	CL0278	AIG2	\N	AIG2/ChaC-like superfamily	Bateman A	anon	The structure consists of a five-stranded beta-barrel surrounded by two alpha-helices and a small beta-sheet.\	Conservation of residues in a hydrophilic cavity able to bind small ligands in some members suggests that this may also serve as an active site.	2008-09-03 15:50:29	2006-12-12 14:39:36	7	20	48	2219	4183	1
+279	CL0279	GatB_YqeY	\N	YqeY-like superfamily	Bateman A	anon	This superfamily includes a domain from GatB as well as one from YqeY. Although being structurally distinct they share a common sequence relationship.	2008-09-03 15:50:29	2007-01-24 12:42:11	6	38	17	4060	6337	1
+280	CL0280	PIN	\N	PIN domain superfamily	Bateman A	anon	This superfamily contains a variety of nuclease enzymes, including PIN domains and the FLAP exonucleases.	2008-09-03 15:50:29	2007-01-25 17:50:12	6	117	241	5231	29721	1
+281	CL0281	CCT	\N	CCT like-motif	Bateman A	anon	This clan includes the CCT motif as well as a related motif that is similar to the first half of the CCT motif.	2008-09-03 15:50:29	2007-01-29 13:51:28	6	21	28	152	1759	1
+282	CL0282	Serum_albumin	\N	Serum albumin superfamily	Bateman A	anon	This superfamily includes serum albumin and related families.	2008-09-03 15:50:29	2007-01-30 15:32:33	6	113	8	71	738	1
+283	CL0283	LigB	\N	LigB-like superfamily	Bateman A	anon	This clan includes the LigB subunit of the aromatic ring opening dioxygenase LigAB [1]. The clan also includes the Memo-like proteins.	2008-09-03 15:50:29	2007-02-12 17:08:37	6	13	17	2285	4015	1
+284	CL0284	Allatostatin	\N	Allatostatin superfamily	Mistry J	anon	Allatostatins are pleiotropic neuropeptides.  In some insects they are known to inhibit the synthesis of juvenile hormone, an important regulator of development and reproduction.  The full role of allatostatins in hormone production is still unclear [1].	2008-09-03 15:50:29	2007-05-04 14:22:41	5	0	16	41	455	1
+285	CL0285	YycI_YycH	\N	YycI/YycH superfamily	Bateman A	anon	Both, YycH and YycI are always found in a pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Structural studies show that these two protein families share two related domains.	2008-09-03 15:50:29	2007-05-14 11:16:06	6	13	4	723	1328	1
+286	CL0286	GCS	\N	gamma-glutamylcysteine synthetase/glutamine synthetase clan	Bateman A, Pei J	anon	This clan represents a superfamily of carboxylate-amine/ammonia ligases [1] that includes Gamma-Glutamylcysteine synthetase (gamma-GCS) and glutamine synthetase (GS). Gamma-Glutamylcysteine synthetase (gamma-GCS) catalyses the first step in the de novo biosynthesis of glutathione.	2008-09-03 15:50:29	2007-08-10 14:04:49	5	394	88	9114	22193	1
+287	CL0287	Transthyretin	\N	Transthyretin superfamily	Bateman A	anon	This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.	2008-09-03 15:50:29	2007-08-14 16:23:44	6	929	1227	4080	40864	1
+288	CL0288	DAP_epimerase	\N	DAP epimerase superfamily	Bateman A	anon	This superfamily includes DAP epimerase and proline racemase as well as the PrpF protein. It has been suggested that this fold may have evolved from the HotDog fold [1].	2008-09-03 15:50:29	2007-08-17 11:58:37	5	61	43	3955	13393	1
+289	CL0289	FBD	\N	Folate binding domain	Bateman A	anon	This folate binding domain is found in the GCV T protein as well as the sarcosine oxidase gamma subunit [1].	2008-09-03 15:50:29	2007-08-17 13:17:41	5	63	59	4863	12811	1
+290	CL0290	EPT_RTPC	\N	EPT/RTPC-like superfamily	Bateman A	anon	This superfamily includes Enolpyruvate transferase (EPT) and RNA 3'-terminal phosphate cyclase (RTPC).	2008-09-03 15:50:29	2007-08-17 13:33:07	5	195	54	4992	12126	1
+291	CL0291	KNTase_C		Nucleotidyltransferase substrate binding domain	Bateman A	anon	This alpha helical domain is found associated with a variety of nucleotidyltransferase domains.	2008-09-03 15:50:29	2007-08-20 15:49:55	6	35	91	3566	11834	1
+292	CL0292	LysE		LysE transporter superfamily	Bateman A	anon	This clan includes a diverse range of transporter families [1].	2008-09-03 15:50:29	2007-10-04 12:03:53	5	0	68	4993	52424	1
+293	CL0293	CDC	\N	Cholesterol-dependent cytolysin superfamily	Bateman A	anon	This superfamily includes the MACPF domain as well as the Cholesterol-dependent cytolysins [1].	2008-09-03 15:50:29	2007-10-19 12:42:17	5	21	68	720	2339	1
+294	CL0294	Sec10	\N	Sec10-like superfamily	Bateman A	anon	This superfamily includes large proteins that are parts of the conserved oligomeric Golgi complex and exocyst complex.	2008-09-03 15:50:29	2007-11-20 17:02:32	5	0	34	298	1198	1
+295	CL0295	Vps51		Vps51 domain superfamily	Bateman A	anon	This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.	2008-09-03 15:50:29	2007-11-20 17:11:52	6	11	168	380	6736	1
+296	CL0296	GroES	\N	GroES-like superfamily	Bateman A	anon	This superfamily includes the GroES protein as well as the N-terminal GroES-like domain from Alcohol dehydrogenase.	2008-09-03 15:50:29	2008-02-08 16:40:31	4	569	527	6115	49027	1
+297	CL0297	PhoU	\N	PhoU-like superfamily	Bateman A	anon	This superfamily includes PhoU and its relatives that contain a three helical bundle domain structure.	2008-09-03 15:50:29	2008-02-08 17:40:34	4	21	32	4083	13356	1
+298	CL0298	tRNA_bind_arm	\N	tRNA-binding arm superfamily	Bateman A	anon	This domain is found in Phe and Ser tRNA synthetases at the N-terminus, and at the C-terminus of Val tRNA synthetase. The domain is composed of two helices.	2008-09-03 15:50:29	2008-02-12 16:57:18	4	43	35	4877	13679	1
+299	CL0299	Peptidase_SF	\N	Peptidase clan SF	Mistry J, Rawlings N	anon	This clan includes the peptidase S24 and S26 families.  These families adopt a mainly beta fold.  Members of the family S24 have an additional C-terminal domain containing a bundle of three helices presumably important for binding DNA.	2008-09-03 15:50:29	2008-02-25 12:55:51	4	47	75	5096	20383	1
+300	CL0300	TAT	\N	Twin-Arginine Translocation Motif	Bateman A	anon	This motif is found in a wide range of secreted proteins. It is named after the conserved pair of arginines that is followed by a hydrophobic stretch.	2008-09-03 15:50:29	2008-02-29 15:32:23	4	26	172	1437	2441	1
+301	CL0301	PA14	\N	PA14 superfamily	Bateman A	anon	This clan includes the PA14 domain and related families.	2008-09-03 15:50:29	2008-03-03 17:31:48	5	32	336	731	2126	1
+302	CL0302	Arginase	\N	Arginase/deacetylase superfamily	Bateman A	anon	This superfamily includes arginase enzymes as well as histone deacetylases and related enzymes [1].	2008-09-03 15:50:29	2008-04-30 14:26:28	5	410	86	3456	11530	1
+303	CL0303	H2TH	\N	Helix-two-turns-helix superfamily	Bateman A	anon	This domain is thought to play a role in binding nucleic acids. It is DNA binding in nucleases and RNA-binding in ribosomal S13.	2008-09-03 15:50:29	2008-05-28 16:24:30	4	289	53	5430	13968	1
+304	CL0304	CheY	\N	CheY-like superfamily	Bateman A	anon	This clan includes the CheY-like response regulators from bacteria [1-2].	2008-09-03 15:50:29	2008-06-04 14:50:30	4	475	3478	5545	154594	1
+305	CL0305	PTH2	\N	Peptidyl-tRNA hydrolase II superfamily	Bateman A	anon	This clan includes Peptidyl-tRNA hydrolase II as well as a large family of uncharacterised proteins called DUF2000. A structure for DUF2000 shows a similar structure to PTH2. It is not clear if the DUF2000 family are also Peptidyl-tRNA hydrolases. Both families contain a conserved positively charged residue close to the amino terminus that may be part of the active site.	2008-09-03 15:50:29	2008-06-05 14:00:28	4	24	15	963	1328	1
+306	CL0306	HeH	\N	LEM/SAP HeH motif	Bateman A	anon	This superfamily includes protein domains with the helix-extended loop-helix (HeH) structure.	2008-09-03 15:50:29	2008-09-03 10:49:37	3	74	240	4102	7665	1
+307	CL0307	FUSC		Fusaric acid resistance protein-like superfamily	Bateman A	anon	Members of this clan are likely to be integral membrane bound transporters.	2008-09-05 13:12:16	2008-09-05 14:12:16	3	0	73	3485	13824	1
+308	CL0308	DMSO_reductase	\N	Dimethyl sulfoxide reductase type II family	Coggill P	anon	This clan includes members that are type II dimethyl sulfoxide reductase families, all of which are also membrane anchor proteins belonging to the iron-sulfur molybdoenzyme (CISM) family [1].	2008-09-23 15:56:29	2008-09-23 16:56:29	3	8	25	1456	4376	1
+310	CL0310	DinB		DinB-like superfamily	Bateman A	anon	This superfamily are thought to be metalloenzymes.  They possess a four helical bundle core structure with a beta hairpin. Members of the superfamily have a predicted active site composed of three histidines that chelate Nickel or Zinc.  In some cases these histidines are replaced with Aspartate or Glutamate.  Mostly they form a dimeric structure. The dinB gene is one of the DNA-damage-induced genes and the corresponding protein, DinB, is the founding member of the clan. The protein contains a four-helix up-down-down-up bundle that has previously been described in the literature in three disparate proteins: the enzyme MDMPI (mycothiol-dependent maleylpyruvate isomerase), YfiT and TTHA0303, a member of a small DUF (domain of unknown function).  Most (but not all) clan members seem to have the ability to coordinate a metal ion using a conserved histidine-triad motif.  The proteins that share the fold exhibit four different quaternary structures: monomeric and three different dimeric forms [1].	2008-10-08 12:01:30	2008-10-08 13:01:30	3	36	73	2472	9715	1
+311	CL0311	SCP2	\N	SCP-2 sterol transfer superfamily	Bateman A	anon	This superfamily includes the SCP2 family as well as a domain from the mycothiol dependent maleylpyruvate isomerase.	2008-10-13 14:19:21	2008-10-13 15:19:21	3	29	62	2115	4976	1
+312	CL0312	HemS_ChuX	\N	Heme iron utilization protein-like superfamily	Bateman A	anon	This superfamily includes HemS and ChuX like protein families.	2008-10-22 16:49:13	2008-10-22 17:49:13	3	13	11	760	1473	1
+314	CL0314	PP-binding	\N	ACP-like superfamily	Bateman A	anon	\N	2008-11-19 12:30:53	2008-11-19 12:30:53	3	127	3226	5406	42314	1
+315	CL0315	Gx_transp		Gx transporter superfamily	Bateman A	anon	This superfamily includes a wide range of transporters that contain many conserved glycine residues in the presumed transmembrane regions.	2008-11-21 16:40:49	2008-11-21 16:40:49	3	4	132	4338	23854	1
+316	CL0316	Acyl_transf_3	\N	Membrane acyl transferase superfamily	Bateman A	anon	This superfamily includes a wide variety of integral membrane acyltransferase enzymes that often acylate sugars.	2008-11-24 13:14:42	2008-11-24 13:14:42	3	0	72	4090	17608	1
+317	CL0317	Multiheme_cytos		Multiheme cytochrome superfamily	Coggill P	anon	This family includes cytochromes that contain multiple CxxCH motifs.	2008-12-10 17:38:20	2008-12-10 17:38:20	3	247	280	1655	11292	1
+318	CL0318	Cytochrome-c		Cytochrome c superfamily	Coggill P	anon	This family includes proteins where a covalently-bound haem completes the core. The core is three helices in an open folded leaf formation. The members are monodomain cytochromes.	2008-12-12 14:30:33	2008-12-12 14:30:33	3	552	457	3452	28903	1
+319	CL0319	SHS2	Rob_SOUL;	SHS2 domain	Bateman A, Anantharaman V	anon	SHS2 is a novel domain with a simple fold containing a core of 3  strands, forming a curved sheet, and a single helix in a  strand-helix-strand-strand (SHS2) configuration [1]. SHS2 is found in the bacterial cell division ATPase FtsA, the archaeo-eukaryotic RNA  polymerase subunit Rpb7p, the GyrI superfamily, and the  uncharacterized MTH1598/Tm1083-like proteins [1]. The fold exists as single copy versions in FtsA (where it is inserted into the RNAseH fold), Rbp7p and Dodecin [1]. It is found as a diad in the GyrI  superfamily. In MTH1598/Tm1083-like proteins two copies of SHS2 are found with one inserted into another [1]. The single-copy versions in FtsA and Rbp7 mediate protein–protein interactions, while the one in  Dodecin is a small molecule binding domain. The GyrI also binds small molecule, while the MTH1598 is predicted to be enzymatic [1].	2008-12-12 19:39:43	2008-12-12 19:39:43	3	250	83	4602	13173	1
+320	CL0320	PepSY	\N	PepSY domain-like superfamily	Bateman A	anon	This family includes the PepSY domain as well as a family of uncharacterised proteins.	2008-12-15 13:39:08	2008-12-15 13:39:08	3	53	124	3218	10624	1
+321	CL0321	PLAT	\N	PLAT domain like superfamily	Bateman A	anon	This domain has an 8-stranded sandwich structure.	2008-12-15 14:40:00	2008-12-15 14:40:00	3	91	192	284	3462	1
+322	CL0322	RND_permease	\N	RND permease superfamily	Bateman A	anon	Different members of the RND superfamily have been shown to transport hydrophobic drugs, fatty acids, bile salts, organic solvents, heavy metals, autoinducers and lipooligosaccharides in bacteria [1].	2008-12-18 12:52:06	2008-12-18 12:52:06	3	91	154	4816	43065	1
+323	CL0323	Patatin	\N	Patatin/FabD/lysophospholipase-like superfamily	Bateman A	anon	This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes.	2008-12-18 16:43:32	2008-12-18 16:43:32	3	75	1413	5254	25679	1
+324	CL0324	Homing_endonuc	\N	Homing endonuclease-like superfamily	Bateman A	anon	This superfamily includes a variety of LAGLIDADG-like homing endonuclease like families.	2009-01-08 17:06:53	2009-01-08 17:06:53	3	109	309	2676	6450	1
+325	CL0325	Form_Glyc_dh	\N	Formate/glycerate dehydrogenase catalytic domain-like superfamily	Bateman A	anon	This superfamily includes the catalytic domain of a variety of dehydrogenase enzymes. The domain has a flavodoxin-like fold and contains an inserted Rossman fold NAD-binding domain.	2009-01-09 10:02:56	2009-01-09 10:02:56	3	370	93	4952	24576	1
+326	CL0326	Reo_sigma	\N	Virus attachment protein superfamily	Bateman A	anon	This superfamily includes virus attachment proteins that share a common beta sandwich domain.	2009-01-09 10:44:19	2009-01-09 10:44:19	3	291	20	282	678	1
+327	CL0327	Pilus	\N	Pilus subunit	Mistry J	anon	This is a clan contains bacterial pilus subunits and proteins involved in secretion.  Pili proteins enable the transfer of plasmid between bacteria. The families in this clan adopt an alpha helical structure which is packed against a beta sheet [2-3].	2009-01-12 11:15:14	2009-01-12 11:15:14	3	115	552	3218	21160	1
+328	CL0328	2heme_cytochrom		Transmembrane di-heme cytochrome superfamily	Bateman A	anon	This superfamily includes a variety of different heme binding cytochromes.	2009-05-08 19:48:23	\N	3	111	270	42880	138619	1
+329	CL0329	S5	\N	Ribosomal protein S5 domain 2-like superfamily	Bateman A	anon	This superfamily contains a wide range of families that possess a structure similar to the second domain of ribosomal S5 protein.	2009-05-08 19:52:37	\N	3	764	344	6126	79017	1
+330	CL0330	AVL9		Late secretory pathway transport machinery	Bateman A	anon	Members of this clan are involved in vesicle formation/trafficking.	2009-05-08 19:52:58	\N	3	2	129	304	2924	1
+331	CL0331	EpsM		General secretion pathway protein M	Coggill P	anon	These families are involved in the general secretory pathways of bacteria and are normally membrane-bound.	2009-05-08 19:53:19	\N	3	6	33	1882	7823	1
+332	CL0332	AcetylDC-like		Acetyl-decarboxylase like superfamily	Coggill P	anon	These families are double psi-beta barrel structures.	2009-05-08 19:53:39	\N	3	175	114	3736	19949	1
+333	CL0333	gCrystallin	gCrystallin-like;	Gamma-Crystallin-like superfamily	Coggill P	anon	This superfamily includes a number of mammalian crystallins as well as ancestral beta gamma-crystallin precursor structures.	2009-05-08 19:54:54	\N	3	107	65	320	3580	1
+334	CL0334	THBO-biosyn		Tetrahydrobiopterin biosynthesis-like enzyme superfamily	Coggill P	anon	The families in this clan bind purine or ptein in topologically similar sites between subunits.	2009-05-08 19:57:58	\N	3	423	52	4568	17543	1
+335	CL0335	FumRed-TM		Fumarate reductase respiratory complex transmembrane subunits	Coggill P	anon	This superfamily constitutes two distinct families: in one family the common fold is contained in a single-chain subunit, in the other it is formed by two chains.	2009-05-08 19:58:20	\N	3	154	20	3092	7355	1
+336	CL0336	FMN-binding		FMN-binding split barrel superfamily	Coggill P	anon	This includes those related to the ferredoxin reductase-like FAD-binding domain and those that are Pyridoxine 5'-phosphate oxidase (PNP)-like.	2009-05-08 19:58:45	\N	3	224	139	4634	22171	1
+337	CL0337	RF	\N	Release factor superfamily	Coggill P	anon	These families are peptide chain release factors.	2009-05-08 19:59:09	\N	3	19	24	4802	12227	1
+339	CL0339	PFL-like		PFL-like glycyl radical enzyme superfamily	Coggill P	anon	The N- and C-terminal halves of the structure have similar topologies but in some cases only one is represented by the members here, viz; the C-terminal domain of the R1 subunit of ribonucleotide reductase, and the N-terminal of PFL. The full-length structure is modelled by NRDD.	2009-05-08 19:59:52	\N	3	156	130	5379	23959	1
+340	CL0340	PTase-anion_tr		Phosphotransferase/anion transport protein superfamily	Coggill P	anon	The families here are the cytoplasmic regions of anion transporter proteins.	2009-05-08 20:00:18	\N	3	25	126	3482	19584	1
+341	CL0341	LDH_C	\N	LDH C-terminal domain-like superfamily	Bateman A	anon	This superfamily includes the C-terminal domain of lactate/malate dehydrogenase as well as the C-terminal domain of the glycosyl hydrolase 4 family.	2009-05-08 20:00:39	\N	3	454	19	7644	15125	1
+342	CL0342	TolB_N		TolB, N-terminal domain	Bateman A	anon	Members of this superfamily appear to behave like the N-terminal fold of the TolB transport-portal complex protein, which is beta-stranded.	2009-05-08 20:00:59	\N	3	23	67	2109	6978	1
+343	CL0343	MHC		MHC antigen-recognition domain	Coggill P	anon	This superfamily includes all the Class I-related antigen-recognition domain families.	2009-05-08 20:01:29	\N	3	1002	27	843	46029	1
+344	CL0344	4Fe-4S		4Fe-4S ferredoxins	Bateman A	anon	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2009-05-08 20:01:52	\N	3	366	2266	6690	129668	1
+345	CL0345	Aerolisin_ETX		Aerolysin/ETX pore-forming domain superfamily	Coggill P	anon	This superfamily includes pore-forming venoms and toxins from bacteria, plants, insects and fish.	2009-05-08 20:02:15	\N	3	26	17	136	416	1
+346	CL0346	Ribo_L29	\N	Ribosomal protein L29, L29p, superfamily	Coggill P	anon	Superfamily includes Ribosomal protein L29 family and its corresponding mitochondrial ribosomal family, L47.	2009-05-08 20:02:37	\N	3	242	12	4897	5412	1
+347	CL0347	Tetraspannin		Tetraspannin-like	Mistry J, Finn RD	anon	This clan includes the tetraspanin family which contains four transmembrane regions.  The CD20 family also has four transmembrane regions, but its members are not considered true tetraspanins as they lack nearly all of the key functional tetraspanin residues [1].	2009-05-08 20:04:53	\N	3	8	50	746	6471	1
+348	CL0348	Phage_tail		Phage virion morphogenesis superfamily	Finn RD, Coggill P	anon	Families involved in joining the tail to the head of the  phage as well as those completing the head are included herein.   	2009-05-08 20:05:12	\N	3	0	8	1841	2993	1
+349	CL0349	DprA		MoCo carrier protein-like superfamily 	Bateman A	anon	Known family members of this superfamily are required for natural chromosomal and plasmid transformation. DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [1]. Superfamily includes lysine_decarboxylases.	2009-05-08 20:05:29	\N	3	59	53	4587	10964	1
+350	CL0350	PRC-barrel	\N	PRC-barrel like superfamily	Finn RD, Coggill P	anon	The PRC-barrel is an all beta barrel domain found in the photosynthetic reaction centre subunit H of the purple bacteria [1]. 	2009-05-08 20:05:48	\N	3	122	34	4098	7238	1
+351	CL0351	CHCH		Coiled-coil helix coiled-coil helix superfamily	Bateman A	anon	The conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain) superfamily members include NADH-ubiquinone oxidoreductases, some cytochrome oxidases and yeast mitochondrial ribosomal proteins. Within each helix of the CHCH domain there are two cysteines present in a C-X9-C motif.	2009-05-08 20:06:07	\N	3	58	39	353	2801	1
+352	CL0352	EsxAB		WXG100-A/WXG100-B dimer	Finn RD	anon	The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (PF06013), such as ESAT-10 (6 kDa early secreted antigenic target) and CFP-10 (10 kDa culture filtrate protein) in Mycobacterium tuberculosis or EsxA (ESAT-6-like extracellularly secreted protein A) and EsxB in Staphylococcus aureus. These two proteins, generally encoded in the same gene cluster, form a 1:1 heterodimeric complex. These proteins are virulence factors involved in host-pathogen interaction [1], as demonstrated in Mycobacterium tuberculosis, Staphylococcus aureus or Bacillus anthracis. The Wss is encoded in many other Gram-positive (monoderm) bacteria. This superfamily contains a number of DUFs which are closely related and may or may not represent the same family of proteins.	2009-05-08 20:06:25	\N	3	34	135	901	12295	1
+353	CL0353	TIMP-like	\N	TIMP-like superfamily	Bateman A	anon	This superfamily consists of the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I procollagen C-proteinase enhancer proteins, as well as the homologous N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs).	2009-05-08 20:06:43	\N	3	69	60	208	1675	1
+354	CL0354	bBprotInhib	\N	beta-Barrel protease inhibitors	Coggill P	anon	Superfamily consists of both metalloprotease- inhibitors and staphostatins.	2009-05-08 20:07:02	\N	2	12	6	424	573	1
+355	CL0355	CheC-like		CheC-like superfamily	Bateman A, Tuff TJ	anon	The chemotactic response regulator superfamily are CheY-P phosphatases. Their structure is two intertwined alpha-beta-(X)-beta(2) motifs. This superfamily comprises two classes of proteins each shown to interact with the chemotaxis response regulator CheY: the FliM switch proteins and the CheC-type phosphatases [1]. FliM is a component of the flagellar switch found across the bacteria and is responsible for binding CheY-P and changing the rotational direction of the flagella. The N-terminal domain is CheC-like and the C-terminal shares the SpoA domain with FliN and FliY. The CheC family is broadly broken down into three phosphatase subfamilies: CheC, CheX, and FliY. All three have an active site consensus sequence of D/S-X(3)-E-X(2)-N-X(22)-P.	2009-05-08 20:07:19	\N	3	20	27	2027	5059	1
+356	CL0356	AMP_N-like		Creatinase/prolidase N-terminal domain superfamily	Coggill P	anon	Bacterial amino-peptidases and creatinases, where the fold is a ribonuclease H-like motif, are grouped in this superfamily.	2009-05-08 20:07:37	\N	3	91	34	4808	10134	1
+357	CL0357	SMAD-FHA		SMAD/FHA domain superfamily	Bateman A	anon	Superfamily members carry a few short helices inserted in loops within the 11 strands in 2 sheets (greek-key) of the parent fold.	2009-05-08 20:07:54	\N	3	135	399	2102	12462	1
+359	CL0359	Intron-mat_II	\N	Type II intron maturase-like superfamily	Bateman A	anon	Superfamily includes a variety of transcription factors that bind intron RNA during reverse transcription and splicing.	2009-05-08 20:08:30	\N	3	14	51	26168	39344	1
+360	CL0360	MTH1187-YkoF		MTH1187/YkoF-like superfamily	Coggill P	anon	Putative cell-wall biogenesis proteins and HMP-binding proteins, all with the same Ferredoxin fold, are included in this superfamily.	2009-05-08 20:08:47	\N	3	35	7	1666	2146	1
+361	CL0361	C2H2-zf		Classical C2H2 and C2HC zinc fingers	Coggill P	anon	Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.	2009-05-08 20:09:05	\N	3	241	8637	2337	328673	1
+362	CL0362	RAMPS-Cas5-like		CRISPR-associated (Cas) Repair Associated Mysterious Proteins	Bateman A, Coggill P	anon	This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats [1]. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation [2]. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers [3].	2009-05-08 20:09:23	\N	3	24	24	1529	4925	1
+363	CL0363	H-int		Hedgehog/intein (Hint) superfamily	Bateman A	anon	This superfamily includes Hedgehog C-terminal (Hog) autoprocessing domain and Intein (protein splicing domain) families.	2009-05-08 20:09:41	\N	3	29	477	1142	3298	1
+364	CL0364	Leu-IlvD	\N	LeuD/IlvD-like	Bateman A	anon	Superfamily includes LeuD-like, IlvD/EDD C-terminal domain-like, and AF0055-like families.	2009-05-08 20:09:58	\N	3	36	36	4411	10971	1
+365	CL0365	MurF-HprK_N		MurF and HprK N-domain-like superfamily	Bateman A	anon	This includes both the MurE/MurF-ligases N-terminal domain and HPr kinase/phosphatase HprK N-terminal domain superfamilies.	2009-05-08 20:10:16	\N	3	14	40	3206	4809	1
+366	CL0366	JAB	Mov34-like;	JAB-like superfamily	Bateman A, Iyer LM, Zhang D, Aravind L	anon	This superfamily includes a number of proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits, regulators of transcription factors and ubiquitination-assisting protein families. In eukaryotes and in prokaryotic cognates of the ubiquitin-based  modification pathway, they function as ubiquitin isopeptidases/ deubiquitinases. JAB domains are also found in diverse metabolic pathways in prokaryotes such as siderophore and cysteine   biosynthesis. Other distinct versions of the JAB domain,  such as RadC are predicted to function as nucleases. Structurally, the  JAB domain is  related to the nucleotide deaminase and binds a Zinc ion in a similar structural location.	2009-05-08 20:10:33	\N	3	35	121	4285	10806	1
+367	CL0367	CI-2		CI-2 family of serine protease inhibitors	Bateman A	anon	This superfamily includes a range of universally found subtilases, that are serine proteases.	2009-05-08 20:10:50	\N	3	54	6	411	761	1
+368	CL0368	PhosC-NucP1	\N	Phospholipase C/P1 nuclease superfamily	Coggill P	anon	This superfamily includes the Phospholipase C and P1-nuclease families.	2009-05-08 20:11:07	\N	3	26	29	2543	5327	1
+369	CL0369	GHD		Glycosyl hydrolase domain superfamily	Bateman A	anon	This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.	2009-05-08 20:11:24	\N	3	345	276	4003	18678	1
+370	CL0370	Uteroglobin		Uteroglobin-like superfamily	Coggill P	anon	Members of this superfamily are disulfide-linked dimers of two identical chains, with 4 helices in each. They constitute important new cat, rat and rabbit allergens that are contributing to asthma world-wide.	2009-05-08 20:11:41	\N	3	12	2	47	309	1
+371	CL0371	Inovirus-Coat	\N	Inovirus (filamentous phage) major coat protein	Coggill P	anon	Superfamily contains a number of filamentous phage coat-protein families.	2009-05-08 20:11:58	\N	3	29	3	67	82	1
+372	CL0372	Hy-ly_N	\N	Hyaluronate lyase-like catalytic, N-terminal domain	Bateman A	anon	This contains virus envelope protein, Chondroitin AC lyase and hyaluronate lyase families.	2009-05-08 20:12:16	\N	3	44	53	774	1055	1
+373	CL0373	Phage-coat		Phage coat superfamily	Coggill P	anon	A number of different phage coat-proteins are collected together in this superfamily.	2009-05-08 20:12:33	\N	3	76	25	2757	4895	1
+374	CL0374	PEP-carboxyk	\N	PEP carboxykinase-like superfamily	Bateman A	anon	This includes the PEP carboxykinase C-terminal domain and HPr kinase HprK C-terminal domain families.	2009-05-08 20:12:50	\N	3	100	16	5373	7630	1
+375	CL0375	Transporter		Transporter superfamily	Bateman A	anon	The members of this superfamily are probably all transporter protein domains.	2009-05-08 20:13:08	\N	3	0	42	409	5210	1
+376	CL0376	Oxa1		Cytochrome oxidase biogenesis family	Bateman A	anon	The cytochrome oxidase biogenesis families are membrane transporters akin to the E coli protein YidC. For those proteins whose N-termini must reside in the intermembrane space, export is mediated by the Oxa1p export machinery, machinery that depends upon the membrane potential. Qxa1p homologues are found in all living organisms. TCDB:2.A.9.	2009-05-08 20:13:27	\N	3	0	30	4817	6863	1
+377	CL0377	FAH	\N	Fumarylacetoacetate hydrolase, C-terminal domain, superfamily	Bateman A	anon	Superfamily contains fumarylacetoacetate hydrolase and related enzymes,	2009-05-08 20:13:45	\N	3	104	39	3513	10941	1
+378	CL0378	ANL	Ac-CoA-synth;	ANL superfamily	Bateman A	anon	This superfamily consists of enzymes including luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely-related synthetases as well as a plant auxin-responsive promoter family.  The name ANL derives from from three of the subfamilies - Acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes [1].  Members of this superfamily catalyse the initial adenylation of a carboxylate to form an acyl-AMP intermediate, followed by a second partial reaction, most commonly the formation of a thioester [1].	2009-05-08 20:14:02	\N	3	149	2269	6257	68785	1
+379	CL0379	PgaPase	\N	Pyroglutamate aminopeptidase superfamily	Bateman A	anon	This is a collection of pyrrolidone carboxyl peptidase or pyroglutamate aminopeptidase families from bacteria and archaea.	2009-05-08 20:14:20	\N	3	60	16	1654	2070	1
+380	CL0380	IDO-like		Indolic compounds 2,3-dioxygenase-like superfamily	Bateman A	anon	Superfamily contains bacterial tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase-like families.	2009-05-08 20:14:37	\N	3	60	18	837	1644	1
+381	CL0381	Metallo-HOrase	\N	Metallo-hydrolase/oxidoreductase superfamily	Bateman A	anon	This superfamily of enzymes including beta-lactamases, thiolesterases, members of the glyoxalase II family that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid all bind two ions of zinc. An additional family of competence proteins essential for natural transformation do not appear to bind zinc, and might be a transporter involved in DNA uptake.	2009-05-08 20:14:54	\N	3	403	305	5380	50665	1
+382	CL0382	DNA-mend	\N	DNA breaking-rejoining enzyme superfamily	Bateman A	anon	This is a superfamily of DNA recombinases, topoisomerases and integrases.	2009-05-08 20:15:13	\N	3	116	209	6017	46990	1
+383	CL0383	PheT-TilS		Phenylalanine- and lysidine-tRNA synthetase domain superfamily	Coggill P	anon	Families here are thought to contain a putative tRNA-binding structural motif. The families are the C-terminal domains of tRNA-Ile-lysidine and the phenylalanine-tRNA synthetases.	2009-05-08 20:15:30	\N	3	31	54	4735	8465	1
+384	CL0384	PLC		PLC-like phosphodiesterases	Coggill P	anon	Superfamily consists of Glycerophosphoryl diester phosphodiesterase and phosphatidylinositol-specific phospholipase C families.	2009-05-08 20:15:48	\N	3	108	279	4173	15000	1
+385	CL0385	Hydrophilin	\N	Hydrophilin-like superfamily	Coggill P	anon	This superfamily includes plant and bacterial hydrophilin families.	2009-05-08 20:16:05	\N	3	0	17	752	2456	1
+386	CL0386	Ant-toxin_C	\N	Superantigen toxins, C-terminal domain superfamily	Coggill P	anon	Superfamily contains bacterial super-antigen toxins and the MAP family.	2009-05-08 20:16:23	\N	3	216	9	194	4767	1
+387	CL0387	DHFred	\N	Dihydrofolate reductase-like	Coggill P	anon	Superfamily contains the dihydrofolate reductases and the RibD C-terminal domain-like including HTP reductase families.	2009-05-08 20:16:40	\N	3	474	41	4883	12238	1
+388	CL0388	FadR-C	\N	Fatty acid responsive transcription factor FadR, C-terminal domain	Coggill P	anon	Superfamily includes C-terminal domain ligand-binding GntR families and families of fatty acid responsive transcription factors. This C-terminal domain, an antiparallel array of six alpha helices, forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain - a separate, DNA-binding winged-helix, domain.	2009-05-08 20:16:57	\N	3	24	47	3168	21611	1
+389	CL0389	TRAF	\N	TRAF domain-like superfamily	Coggill P	anon	Superfamily has a circularly permuted immunoglobulin-fold topology with extra an extra beta-strand. Families include the Math and the SIAH, or Seven in absentia, members.	2009-05-08 20:17:16	\N	3	106	201	1094	6315	1
+390	CL0390	zf-FYVE-PHD		FYVE/PHD zinc finger superfamily	Coggill P	anon	Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.	2009-05-08 20:17:33	\N	3	184	1096	1231	20485	1
+391	CL0391	CAP_C-like		Adenylate cyclase associated (CAP) C terminal like 	Mistry J	anon	Families in this clan adopt a beta super helix structure [1-2].  The clan includes the C terminal domain of adenylate cyclase which binds binds actin [1].	2009-05-08 20:17:50	\N	3	14	29	324	1064	1
+392	CL0392	Chaperone-J	\N	Chaperone J-domain superfamily	Coggill P	anon	The J-domain is found in a number of stress-response proteins.  It is found at the N-terminal of Hsc20, DnaJ-chaperone in E. coli,  and viral large T-antigen proteins; it is also in Hsc40, mammalian  auxilin and in both animal and plant DnaJ proteins. It is also  found in degenerate form in Pam16 proteins.	2009-05-08 20:18:07	\N	3	72	636	5592	28318	1
+393	CL0393	FucI-AraA_C	\N	FucI/AraA C-terminal domain-like [50443] 	Coggill P	anon	The enzymes in this superfamily function as a hexamer, which is the largest structurally known ketol isomerase, that has no  sequence or structural similarity to other ketol isomerases.	2009-05-08 20:18:26	\N	3	24	7	1558	2470	1
+394	CL0394	DsrEFH-like	\N	DsrEFH-like superfamily	Bateman A	anon	This is a superfamily of small proteins from phototrophic sulfur bacteria that are involved in oxidisation of  intracellular sulfur.	2009-05-08 20:18:45	\N	3	54	21	2423	6201	1
+395	CL0395	Tubby_C		Tubby C-terminal domain-like 	Bateman A	anon	This superfamily contains the scramblase protein family, the Tub family and the DUF567, a family of plant and bacterial proteins of hitherto unknown function. All members are membrane-tethered transcription factors.	2009-05-08 20:19:04	\N	3	9	44	886	2617	1
+396	CL0396	Marvel-like		MARVEL domain containing superfamily	Bateman A	anon	The MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families.	2009-05-08 20:19:22	\N	3	0	28	346	3075	1
+397	CL0397	TusA-like	SirA-like;	TusA-like superfamily	Bateman A	anon	Member families include sulfurtransferase TusA.	2009-05-08 20:19:39	\N	3	8	61	3075	6124	1
+398	CL0398	RMMBL_DRMBL	\N	RNA/DNA-metabolising metallo-beta-lactamase motif	Mistry J	anon	This clan contains the fifth motif found in RNA and DNA metabolising metallo-beta-lactamases.  The fifth motif appears to be specific to function [1].	2009-05-08 20:19:56	\N	3	52	66	3672	6801	1
+399	CL0399	Asp-glut_race		Aspartate/glutamate racemase superfamily	Bateman A	anon	Superfamily contains aspartate racemase, glutamate racemase, hydantoin racemase and arylmalonate decarboxylase families from fungi, plants, bacteria and archaeal species.	2009-05-08 20:20:14	\N	3	108	17	4346	8931	1
+400	CL0400	GG-leader	\N	Double-Glycine leader-peptide cleavage motif	Coggill P	anon	This is a collection of short bacterial families that  carry a distinctive GG-cleavage motif. Conservation C-terminal to the GG-motif is not apparent. However, the families are  all interconnected with critical virulence attributes of one  kind or another.	2009-05-08 20:20:32	\N	3	5	10	475	1960	1
+401	CL0401	AsmA-like		AsmA-like OmpF regulator protein superfamily 	Bateman A	anon	Families in this collection are AsmA-like. Mutations in the AsmA gene restore the assembly of OmpF, a trimeric outer membrane porin from E coli and related bacteria necessary for the cytotoxic action of group-A colicins.	2009-05-08 20:20:49	\N	3	0	60	2432	11866	1
+402	CL0402	Cdc48_2-like		Cdc48 domain 2-like	Coggill P	anon	Superfamily contains C-terminal domains of N-ethylmaleimide sensitive fusion proteins, VCP-like ATPases, membrane fusion ATPase p97 domain 2, peroxisome biogenesis factor 1 (PEX-1), domain 2, and ubiquitin fusion degradation protein UFD1 families.	2009-05-08 20:21:06	\N	3	52	46	547	1899	1
+403	CL0403	ADC-like	\N	Acetoacetate decarboxylase-like	Finn RD	anon	Superfamily contains the acetoacetate decarboxylase enzyme family EC:4.1.1.4, and a family of uncharacterized proteins from bacteria.	2009-05-08 20:21:23	\N	3	20	14	682	968	1
+404	CL0404	BPD_transp_1	BPD_transp_1-like;	BPD transporter like	Mistry J, Finn RD	anon	This clan contains families that are involved in transport of molecules across membranes.  It includes the bacterial binding protein-dependent transport system inner membrane component, Pfam:PF00528, which is ATP dependent system involved in transport of a range of substrates [1-2].	2009-05-08 20:21:41	\N	3	36	162	5100	199771	1
+405	CL0405	DNA_b-psBarrel	DNA-bdg_psBarrel;	DNA-binding pseudo-barrel domain	Finn RD	anon	Superfamily consists of type II restriction endonuclease effector (N-term) domain and plant B3 DNA binding domain families.	2009-05-08 20:21:58	\N	3	5	51	174	2348	1
+406	CL0406	YjbJ-CsbD-like		YjbJ-CsbD-like superfamily	Finn RD	anon	CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor [1]. The role of CsbD in stress response is unclear. YjbJ is a hypothetical protein with a similar structure.	2009-05-08 20:22:16	\N	3	2	5	2526	5640	1
+407	CL0407	TBP-like		TATA-binding protein like	Mistry J, Finn RD	anon	TBP is a transcription factor whose DNA binding fold is composed of a curved antiparallel beta-sheet [1].  This fold is also found in the N terminal region of DNA repair glycosylases.  The N terminal domain of DNA glycosylase has only a single copy of the fold, whereas TBP contains a duplication of this fold [2-3].	2009-05-08 20:22:35	\N	3	138	32	2007	3848	1
+408	CL0408	PUP	\N	Purine and uridine phosphorylase superfamily	Bateman A	anon	superfamily contains a number of purine nucleoside phosphorylase, uridine nucleoside phosphorylase, and various nucleosidase families of proteins.	2009-05-08 20:22:53	\N	3	825	229	4830	16130	1
+409	CL0409	GAP	\N	GTPase activation domain superfamily	Finn RD	anon	Superfamily contains BCR-homology GTPase activation domain (BH-domain) and p120GAP domain-like, including the GAP related domain of neurofibromin, families.	2009-05-08 20:23:11	\N	3	42	410	365	9451	1
+410	CL0410	LEF-8-like		LEF-8 like region of RNA polymerase Rpb2	Mistry J, Finn RD	anon	Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to domain 6 of the second largest subunit of prokaryotic DNA-directed  RNA polymerase[1].	2009-05-08 20:23:28	\N	3	138	141	12554	17032	1
+411	CL0411	Vir		Antigenic variants from Plasmodium cell-surface	Finn RD	anon	Several families of paralogous proteins are included in this superfamily, largely from Plasmodium species. The genome expresses great numbers of them, and they vary subtly from each other.	2009-05-08 20:23:45	\N	3	0	7	9	1914	1
+412	CL0412	Frag1-like	\N	Frag1 like	Mistry J, Finn RD	anon	This clan contains the Frag1/DRA</Sfk1 Pfam family (Pfam:PF10277) and related families.	2009-05-08 20:24:02	\N	3	0	22	963	1905	1
+413	CL0413	Toprim-like		Toprim domain	Finn RD	anon	This is families that have a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1].	2009-05-08 20:24:21	\N	3	91	322	8438	38368	1
+414	CL0414	TerB	AB-resistance;	Tellurits and antibiotic resistance superfamily	Finn RD	anon	A number of families which show resistance to antibiotics or tellurite are included here.	2012-09-28 17:52:30	\N	3	5	36	1833	3980	1
+416	CL0416	Anoctamin-like	\N	Transmembrane protein families of the Anoctamin type	Finn RD, Coggill P	anon	The families are transmembrane families, where some of the members have sodium tolerance activity.	2009-05-08 20:25:15	\N	3	0	98	322	3409	1
+417	CL0417	BIR-like	\N	BIR-like domains	Mistry J, Finn RD	anon	Clan of domains all involved in binding nucleic acid and sharing the sequence motif C3HC.	2009-05-08 20:25:32	\N	3	187	45	401	2356	1
+418	CL0418	GIY-YIG	\N	GIY-YIG endonuclease superfamily	Finn RD, Coggill P	anon	Based on the analysis of genomic distribution, patterns of domain fusions and phylogenetic considerations for individual families, an evolutionary scenario is proposed that explains the emergence and development of the major branches of the GIY-YIG superfamily that links the Slx-type with the UvrC-like endonucleases. Most families appear to target DNA. The GIY-YIG domain has been quite successful in forming monomeric nucleases that utilise additional domains to recognise its DNA targets; this collection of domains can range from extremely simple DNA-binding elements (as in the case of I-TevI) to modules with independent enzymatic activities (as in the case of UvrC or the Penelope elements) [1].	2009-05-08 20:25:49	\N	3	20	115	5010	11825	1
+419	CL0419	T3SS-Chaperone	\N	Type III secretion system types a and b chaperone	Finn RD, Coggill P	anon	Type III secretion systems of the two forms, a - translocation-associated, and b - bacterial flagellum, share homology between comparable parts. This superfamily includes the chaperone proteins FliJ and HrpB7.	2009-05-08 20:26:06	\N	3	1	5	1738	1982	1
+420	CL0420	GlpM-like	\N	Bacterial membrane GlpM-like group	Finn RD, Coggill P	anon	This is a group of membrane proteins of the GlpM type.	2009-05-08 20:26:23	\N	3	0	3	964	1206	1
+421	CL0421	LppaM	\N	Lipo-protein attachment motif superfamily	Bateman A	anon	Superfamily consists of those protein families wherein the lipo-protein attachmnet motif, usually at the N-terminus, is found. regions of sequence downstream of this motif may not be conserved between families in the clan.	2009-05-08 21:19:03	\N	3	0	25	1166	2588	1
+422	CL0422	Fibrinogen_C		Fibrinogen C-terminal domain-like	Finn RD	anon	This is a collection of families with C-terminal domains that are of similar structure.	2009-05-08 21:19:20	\N	3	239	308	1080	6291	1
+423	CL0423	AhpD-like	\N	AhpD-like superfamily	Bateman A	anon	Superfamily contains CMD-like, and Antioxidant defense protein AhpD families.	2009-05-08 21:19:37	\N	3	112	49	3494	9816	1
+424	CL0424	T3SS-hook		Type III secretion system-derived superfamily, hook-related	Coggill P	anon	There is homology between the proteins forming the flagellar system and those involved in translocation of effector proteins at host-infection.  Both systems, in Gram-negative bacteria, are Sec-independent but ATPase-dependent.  There are up to 9 proteins that are homologous between the two systems.  It is not clear, however, why HpaP proteins, which are essentially suppressants of HrpB2, an essential pathogenicity factor, should also be homologous to any of these families.	2009-05-08 21:19:55	\N	3	1	12	3179	4912	1
+425	CL0425	ComplexI-N	\N	NADH dehydrogenase I, subunit N	Bateman A	anon	This superfamily contains proteins from the families Oxidored_q1 and NADHdeh_related. The Oxidored_q1 family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane. Many members of the NADHdeh_related family are archaeal and bacterial, indicating the evolutionary origins of ComplexI.	2009-05-08 21:20:12	\N	3	6	58	35038	91907	1
+426	CL0426	HRDC-like	\N	HRDC-like superfamily	Coggill P	anon	Superfamily includes HRDC domain from helicases, RNA polymerase II subunit RBP4, RNase D C-terminal domains, and EXOSC10 HRDC domain-like families.	2009-05-08 21:20:30	\N	3	84	86	3700	6906	1
+428	CL0428	TolA-TonB-Cterm		TolA/TonB C-terminal	Mistry J, Finn RD	anon	This clan contains the TolA and TonB C terminal domains.  These domains adopt a structure containing anti-parallel beta sheets with some alpha helical regions. The TolA family contains an extra N-terminal helix over the common fold, and the TonB is an isolated domain that can form different segment-swapped dimers depending on the fragment length [1].	2009-05-08 21:28:43	\N	3	17	93	2250	7994	1
+429	CL0429	UcrQ-like	\N	UcrQ-like	Finn RD	anon	The families here include those that are the H and S chains of cytochrome c subunit B1.	2009-05-08 21:29:01	\N	3	51	6	247	299	1
+430	CL0430	CopD_like		Copper resistance protein D	Mistry J	anon	This clan contains families that are related to the CopD family of proteins.\	    CopD, together with CopC, performs copper uptake into the cytoplasm.	2009-05-08 21:29:20	\N	3	0	20	2640	4510	1
+431	CL0431	PF		Profilin-like superfamily	Bateman A	anon	The families here all show the Profilin-like fold, and represent both the Profilin (actin-binding protein) (55770) and the Roadblock/LC7 domain-type (103196) superfamilies.	2009-05-08 21:29:38	\N	3	97	27	918	3101	1
+433	CL0433	SPFH	\N	SPFH superfamily	Bateman A	anon	This superfamily includes the SPFH family as well as the shoulder domain from the Major Vault Protein [1].	2009-07-06 09:16:10	\N	3	46	70	4547	14789	1
+434	CL0434	Sialidase		Sialidase superfamily	Bateman A	agb	This superfamily includes sialidases enzymes.  Several viruses use sialic acid as a cell surface receptor for host invasion. These viruses then have cell surface neuraminidase enzymes to cleave sialic acid from cell surface proteins allowing them to leave the host cell after replication.  This superfamily are composed of six beta-sheets that form a six-fold beta-propeller structure. Many members of this superfamily contain BNR sequence motifs Pfam:PF02012.	2009-08-03 11:40:27	2009-08-03 12:40:27	3	387	191	30583	37487	1
+435	CL0435	NPR		Nitrogen permease regulator family	Coggill P	pcc	The several protein families of nitrogen permease regulators, that complex together and regulator TORC1 in response to amino acid starvation are likely to have arisen by a gene duplication event.	2009-08-24 12:51:07	2009-08-24 13:51:07	3	0	11	254	791	1
+436	CL0436	FliG		Flagellar motor switch family	Coggill P	pcc	This superfamily is characterised by a fragmented superhelix consisting of 3-4 helical motifs and connecting helices. Memebers include the direct flagellar motor as well as the MG2+ families.	2009-08-24 13:45:28	2009-08-24 14:45:28	3	22	37	3585	10762	1
+437	CL0437	EF-G_C		Transcription elongation factor G C-terminal	Coggill P	pcc	This superfamily is characterised by being an alpha-beta 2-Layer Sandwich. It is found in EF2 proteins from both prokaryotes and eukaryotes, as well as in some tetracycline resistance proteins, peptide chain release factors ], and in the C-terminal region of the bacterial hypothetical protein, YigZ.	2009-08-24 15:16:01	2009-08-24 16:16:01	3	77	100	5888	33570	1
+438	CL0438	TTHA10132-281		Transcriptional regulators of TTHA1013 andTTHA0281 type	Coggill P	pcc	These families are characterised by sharing a 2-layer, beta(3)-alpha-beta topology. Domains dimerise via the long C-terminal strand with the formation of a single beta-sheet.	2009-08-24 16:09:48	2009-08-24 17:09:48	3	12	22	1503	2871	1
+439	CL0439	NusG-like		NusG-like	Mistry J	jm14	Members of this clan are related to the NusG transcription termination factor.  The eukaryotic orthologue of NusG is Spt5 [1].	2009-08-25 13:27:05	2009-08-25 14:27:05	3	24	30	4806	6515	1
+441	CL0441	AlbA		RNA-DNA binding Alba-like superfamily	Coggill P	pcc	This is a family of DNA and RNA binding proteins found from archaea to humans.	2009-08-27 10:57:56	2009-08-27 11:57:56	3	32	9	406	878	1
+442	CL0442	Tubulin-like	Tubulin_C;	Tubulin, FtsZ and Misato and their C-termini, GTPase	Coggill P	pcc	This superfamily is characterised by being of alpha-beta two-layer sandwich structures.  A segmental duplication early on in the primate lineage has led to the creation of up to three tubulin-like domains in the higher primates. The most N-terminal one is the Misato domain, which probably represents the original domain [3].	2009-08-28 12:07:36	2009-08-28 13:07:36	3	172	73	11198	35977	1
+444	CL0444	YNI		YcfA-nrd-intein domain	Coggill P	pcc	This superfamily is characterised by a short approx. 55 residue fold that is found in domains associated with flagellum formation and a short region withiin the homing endonucleases.	2009-09-10 10:49:46	2009-09-10 11:49:46	3	3	8	2112	3558	1
+445	CL0445	SNARE-fusion		SNARE-fusion membrane complex superfamily	Coggill P	pcc	The SNARE-fusion complex families are characterised by being tetrameric coiled-coil structures.	2009-09-10 14:55:14	2009-09-10 15:55:14	3	106	90	533	8433	1
+446	CL0446	Bacteriocin_TLN		Translocation domain of colicin-like bacteriocins	Coggill P	pcc	A number of different bacterial species produce bacteriocins to kill competitor species, and the colicin class is a group of complex three-domain structures. The receptor-binding domain recognises and binds to specific cell surface receptors on the target cells; the N-terminal translocation domain interacts with cell membrane proteins to gain access to the cell interior; the C-terminal domain specifies a killing activity, such as pore formation or nuclease activity. This superfamily is a collection of the translocating domains.	2009-11-02 18:54:23	2009-11-02 18:54:23	2	20	31	181	342	1
+447	CL0447	Hypoth_1		DUF1304/DUF3784 clan	Bateman A	agb	This superfamily includes two related families of short uncharacterised proteins from bacteria.	2009-11-06 14:19:03	2009-11-06 14:19:03	2	0	9	1408	1614	1
+448	CL0448	Cargo_bd_muHD		Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	Coggill P	pcc	Internalisation of diverse transmembrane cargos from the plasma membrane requires a similarly diverse array of specialized adaptors, this domain is the binding domain of these endocytioc adaptors. The muHD binds directly to the cytosolic tail of the Mid2 (for the transmembrane stress sensor protein Mid2) cargo protein and mediates Mid2 internalization [1]. These are all-beta proteins.	2009-11-10 17:50:06	2009-11-10 17:50:06	2	32	35	501	2637	1
+449	CL0449	G-PATCH		DExH-box splicing factor binding site	Coggill P	pcc	This superfamily is characterised by domains which are related to the G-patch domain in proteins with RNA-binding/splicing activity. This domain affects RNA-splicing by binding to a DExH-box splicing factor.	2009-11-12 13:38:49	2009-11-12 13:38:49	2	0	141	389	3724	1
+450	CL0450	FimbA		Fimbriae A and Mfa superfamily	Xu Q, Finn RD, Coggill P	pcc	To add the reference from ActaF when it is published, A conserved fold for fimbriae components revealed by the crystal structure of a putative fimbriae assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Angstrom resolution.  This family includes the fimbrillin-A set of fimbrial proteins and the shorter Mfa1 fimbrial set and their asoociated anchor-proteins Mfa2.	2009-11-25 16:52:50	2009-11-25 16:52:50	2	11	10	96	707	1
+451	CL0451	FnI-like		von Willebrand Factor like superfamily	Coggill P	pcc	This superfamily is characterised by being disulfide-rich, all-beta with an extra C-terminal domain in the fibronectin-like, Fn1, members.	2009-12-18 14:27:48	2009-12-18 14:27:48	2	8	460	161	4895	1
+452	CL0452	Tropomyosin-lke		Tropomyosin-like superfamily	Coggill P	pcc		2009-12-18 15:27:21	2009-12-18 15:27:21	2	54	27	554	1620	1
+453	CL0453	Apoptosis-Inhib		Inhibitors of suppressors of apoptosis Bax/Bak 	Coggill P	pcc	This family includes members which are Bax inhibitors.	2009-12-23 16:41:04	2009-12-23 16:41:04	2	0	14	4078	6492	1
+454	CL0454	Protease_inhib		Protease inhibitor toxin superfamily	Coggill P	pcc	This superfamily includes several families of toxins which seem to act as protease inuibitors.	2010-01-05 09:18:17	2010-01-05 09:18:17	2	215	445	329	6504	1
+455	CL0455	MIM-OM_import		Mitochondrial membrane transporting or complex assembly	Coggill P	pcc	This superfamily is characterised by being mitochondrial membrane proteins with importing activities.	2010-01-07 14:15:14	2010-01-07 14:15:14	2	1	8	326	612	1
+456	CL0456	Golgi_traff		Shuttling between cyosol and Golgi, peripheral membrane family	Coggill P	pcc	This superfamily is characterised by comprising multiple-pass membrane proteins that are associated with various aspects of trafficking of molecules into and out of the Golgi apparatus.	2010-01-08 15:41:51	2010-01-08 15:41:51	2	0	13	303	639	1
+457	CL0457	4HB_MCP		Aspartate chemoreceptor, signal-transduction ligand-binding	Ulrich L, Coggill P	pcc	This superfamily is characterised by a four-helix bundle structure that forms a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.	2010-01-11 14:55:11	2010-01-11 14:55:11	2	16	242	1922	9476	1
+458	CL0458	IIaaRS-ABD		Class II aaRS Anticodon-binding domain-like	Coggill P	pcc	This superfamily is characterised by including the anticodon-binding domain of Class II aaRS and the Brix domain.	2010-02-01 17:01:44	2010-02-01 17:01:44	2	142	103	4984	18087	1
+459	CL0459	BRCT-like		BRCT like 	Coggill P	pcc	The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage.	2010-02-01 17:02:12	2010-02-01 17:02:12	2	112	343	4755	10126	1
+461	CL0461	Metallothionein		Metal-bound fold, usually iron, metallothionein superfamily	Coggill P	pcc	This superfamily contains related families of metallothioneins, prokaryotes and eukaryotes.	2010-02-03 17:36:45	2010-02-03 17:36:45	2	24	9	332	753	1
+462	CL0462	TPA-repeat		Transcription elongation factor C-terminal nonapeptide repeat	Coggill P	pcc	This superfamily includes several families of this nonapeptide repeat, that carries a characteristic TPA motif. The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II.	2010-02-04 11:33:22	2010-02-04 11:33:22	2	10	36	254	580	1
+464	CL0464	5_3_exonuc_C		5'-3'-exonuclease C-terminal sub-region	Coggill P	pcc	This superfamily includes C-terminal domains from a number of DNA-processing enzymes including T4 RNase H, 5' to 3' exonuclease domain of DNA polymerase Taq, T5 5'-exonuclease, Flap endonuclease-1 (Fen-1 nuclease), and other eukaryotic endonucleases.	2010-02-04 17:13:51	2010-02-04 17:13:51	2	38	66	5048	8326	1
+465	CL0465	Ank		Ankyrin repeat superfamily	Bateman A	agb	The ankyrin repeat is a short sequence region that is about 30-34 amino-acids in length. Multiple copies of the repeat composed of two beta strands and two alpha helices combine to form long arrays. In general these repeats are involved in protein-protein interactions. This superfamily also includes some families that are arrays of several repeats.	2010-02-18 14:19:32	2010-02-18 14:19:32	2	168	6571	3000	134027	1
+466	CL0466	PDZ-like		PDZ domain-like peptide-binding superfamily	Coggill P	pcc	This superfamily comprises families of PDZ domains, which are peptide binding sites.	2010-02-23 10:29:00	2010-02-23 10:29:00	2	615	901	4966	46701	1
+468	CL0468	Malectin-like		Malectin-like superfamily	Coggill P	pcc	This superfamily includes several families of Malectin-type domains.	2010-02-24 16:54:44	2010-02-24 16:54:44	2	3	227	339	1899	1
+469	CL0469	l-integrase_N		lambda integrase N-terminal domain	Coggill P	pcc	This superfamily is characterised by families having 4-5 helices in a bundle of two orthogonally packed alpha-hairpins that are involved in interactions with DNA and proteins.	2010-02-24 17:58:15	2010-02-24 17:58:15	2	29	85	4649	20176	1
+470	CL0470	UMP_1		Uncharacterised membrane protein superfamily (UMP1)	Bateman A	agb	This superfamily includes two related families of membrane proteins. One of these is known as DUF1212. As yet there is no known function for any of these proteins.	2010-02-25 14:21:20	2010-02-25 14:21:20	2	0	13	2781	7529	1
+471	CL0471	DUF362		DUF362-like superfamily	Bateman A	agb	This superfamily incldues two uncharacterised families: DUF362 and DUF2088. These families contain a number of potential conserved metal binding residues and may be metalloenzymes.	2010-03-01 12:56:12	2010-03-01 12:56:12	2	2	26	685	1641	1
+472	CL0472	Peptidase_U		Peptidase clan U	Bateman A	agb	This superfamily includes proteins classed as clan U by the MEROPS database. The proteins are membrane bound peptidases.  The clan also includes Pfam:PF10086 which is a related family of uncharacterised proteins.	2010-03-11 15:27:58	2010-03-11 15:27:58	2	0	61	3770	14791	1
+474	CL0474	SICA_like		SICA alpha/beta like extracellular domains	Finn RD	rdf	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of three domains (alpha, beta and C-terminal).  The two extracelullar domains, termed SICA alpha and beta, occur with varying copy number.  The alpha domain, although it appears to be related to the beta domain, contains few cysteine residues and is found between 1 and 2 times, compared with the beta domain that occurs between 1 and 10 times (when present) [1].	2010-03-17 15:36:20	2010-03-17 15:36:20	2	0	38	2	575	1
+475	CL0475	Cyclophil-like		Cyclophilin-like superfamily	Coggill P	pcc	This superfamily is characterised by being the core, closed, beta barrel of cyclophilin with complex topology, with some family members lacking the N-terminal strand of cyclophilin but retaining a closed barrel.	2010-03-22 18:14:27	2010-03-22 18:14:27	2	310	183	4947	18056	1
+476	CL0476	tRNA-IECD_N		tRNA-intron endonuclease catalytic domain-like N-term	Coggill P	pcc	This superfamily contains families of the N-termini of tRNA-splicing endonucleases.	2010-04-13 08:59:45	2010-04-13 09:59:45	2	33	16	391	617	1
+477	CL0477	TRD		DNA methylase specificity domain	Bateman A	agb	This superfamily includes domains that are found associated with restriction modification methylase enzymes. These domains are involved in defining the DNA substrate specificity.	2010-05-04 15:55:02	2010-05-04 16:55:02	2	29	59	3119	12266	1
+478	CL0478	ATPase_I_AtpR	F_N_ATPase_a;	F-type and N-type ATPase, I/AtpR subunit 	Galperin M, Finn RD	rdf	These two subunits from the F-type and N-type ATPases have been demonstrated to from functionally distinct components of these two different ATPases[1].	2010-05-19 12:41:39	2010-05-19 13:41:39	2	0	2	1835	2145	1
+479	CL0479	PLD		Phospholipase D superfamily	Bateman A	pcc	This superfamily includes proteins that are related to Phospholiase D.	2010-06-17 09:09:37	2010-06-17 10:09:37	2	68	157	5070	25964	1
+480	CL0480	Ribosome_L1		Ribosomal L1 protein superfamily	Coggill P	pcc	This is a superfamily of Ribosomal L1 protein families.	2010-06-29 09:40:59	2010-06-29 10:40:59	2	95	18	4960	6004	1
+481	CL0481	HUH		His-hydrophobic-His tranposase Y1,Y2 superfamily	Coggill P	pcc	This superfamily consists of families of transposases that use tyrosine as nucleophiles and contain a conserved HUH motif where U is a non-conserved hydrophobic residue. Particular examples are the Y1 and Y2 transposases. Y1 transposases come from the IS608 group and the Y2 from the IS91 group. These transposases are nucleases involved in initiating rolling-circle plasmid replication, in initiating replication of certain single-strand (ss) DNA viruses (Rep proteins), and in initiation of conjugative plasmid transfer (relaxases). The IS91 transposase contains two of the three conserved protein sequence motifs identified in RCR proteins, a His-hydrophobic-His (HUH) motif required for metal ion binding, and a YxxxY motif containing two conserved catalytic tyrosine residues. The HUH motif participates in coordinating divalent metal ions essential for catalysis.  This clan is also known as the Transposase IS200-like whose members contain extra N-terminal hairpin and C-terminal helix, both or which are involved in dimerisation; there can be helix-swapping in the dimer.	2010-07-13 12:33:47	2010-07-13 13:33:47	2	40	49	2384	6860	1
+482	CL0482	Prolamin		Di-sulfide bond pairrings	Coggill P	pcc	This superfamily is characterised by families with only slightly differing disulfide-bonding patterning.	2010-07-21 12:41:48	2010-07-21 13:41:48	2	54	35	364	5909	1
+483	CL0483	PreATP-grasp		Probable substrate-binding preceding ATP-grasp domain	Coggill P	pcc	This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.	2010-07-21 12:47:06	2010-07-21 13:47:06	2	32	18	1652	2776	1
+484	CL0484	Peroxisome		Peroxisome-like domain	Coggill P	pcc	This superfamily combines peroxisome families and a family found at the C-terminus of metazoan phosphoribosyltransferases.	2010-07-21 12:49:56	2010-07-21 13:49:56	2	0	76	283	1175	1
+486	CL0486	Fer2		2Fe-2S iron-sulfur cluster binding domain	Bateman A	agb	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domani is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	2010-07-24 11:00:26	2010-07-24 12:00:26	2	362	461	5503	37176	1
+487	CL0487	FKBP		FKBP-like superfamily	Bateman A	agb	This superfamily includes the FKBP domain which catalyses the peptidyl-prolyl cis-trans isomerisation reaction. The superfamily also includes the C-terminal domain of GreA and the c-terminal dmoain of 3-mercaptopyruvate sulfurtransferase.	2010-07-25 11:45:24	2010-07-25 12:45:24	2	104	100	4781	19148	1
+488	CL0488	FixH-like		FixH-like	Coggill P	pcc	This is a superfamily of FixH-like proteins of unknown function.	2010-07-28 13:48:41	2010-07-28 14:48:41	2	0	16	1183	1566	1
+489	CL0489	AFP_III-like		Type III antifreeze and spore coat polysaccharide	Coggill P	pcc	This is a superfamily of antifreeze proteins, flagellar FlgA, pilus and spore coat polysaccharide families.	2010-07-29 13:32:26	2010-07-29 14:32:26	2	26	28	2940	6862	1
+490	CL0490	PepSY_TM-like		PepSY_TM-like	Coggill P	pcc	This is a superfamily of PepSY-transmembrane-like domain families.	2010-08-04 15:51:29	2010-08-04 16:51:29	2	0	70	1771	6672	1
+491	CL0491	LYR-like		Complex1_LYR-like superfamily	Coggill P	pcc	This is a superfamily of sequences with the characteristic LYR, or similar, motif. In some yeasts this family plays a role in Fe-S cluster biogenesis in mitochondria.	2010-08-19 16:20:34	2010-08-19 17:20:34	2	0	33	323	2362	1
+492	CL0492	S4		S4 domain superfamily	Bateman A	agb	This superfamily includes diverse proteins related to the ribosomal S4 protein.	2010-08-27 15:46:09	2010-08-27 16:46:09	2	226	44	10099	38684	1
+493	CL0493	PTS_EIIC		Phosphotransferase system, EIIC superfamily	Bateman A	agb		2010-09-02 14:47:12	2010-09-02 15:47:12	2	4	39	2905	27857	1
+494	CL0494	DnaA_N		DNA-A N-terminal domain-like superfamily	Bateman A	agb	This superfamily includes the N-terminal domain from DnaA and the N-terminal domain from DNA polymerase III alpha subunit.	2010-09-17 12:39:03	2010-09-17 13:39:03	2	2	33	3617	4495	1
+496	CL0496	Tad-like		Flp pilus-biogenesis Tad-like superfamily	Coggill P	pcc	This is a superfamily of Tad-like protein families all involved in Flp pilus biogenesis.	2010-09-28 15:11:00	2010-09-28 16:11:00	2	0	22	1048	3415	1
+497	CL0497	GST_C		Glutathione S-transferase, C-terminal domain	Bateman A	agb	This clan represents the C-terminal domain of Glutathione S-transferase.	2010-10-04 10:28:59	2010-10-04 11:28:59	2	839	219	3208	23337	1
+498	CL0498	Nribosyltransf		N-(deoxy)ribosyltransferase-like superfamily	Bateman A	agb	This superfamily includes the N-deoxyribosyltransferase and ADP-ribosyl cyclase-like families as well as the family that includes the hypothetical protein PA1492 for which the structure is known. PA1942 has a very similar putative active site and is predicted by SCOP to have a deoxyribosyltransferase activity [1].	2010-10-07 15:46:04	2010-10-07 16:46:04	2	193	14	1181	1635	1
+499	CL0499	O-antige_ligase		O-antigen-ligase like superfamily	Coggill P	pcc	This superfamily is characterised by a group of bacterial proteins that are membrane proteins, and include O-antigen ligases and putative hydrogen carbonate transporters [1].	2010-10-07 17:04:39	2010-10-07 18:04:39	2	0	73	3419	7279	1
+500	CL0500	Glycine-zipper		Glycine-zipper TM superfamily	Coggill P	pcc	This superfamily is characterised by having long glycine-zipper motifs, characteristically GxxxGxxxG [1], often with several contiguous copies. The x following the G is frequently found to be an alanine. This sequence region can be found in both symmetric and non-symmetrical membrane structures, and is relatively common. The fact that such a large fraction of the relatively few known membrane channel structures use the glycine zipper suggests that the sequence motif plays a special role in forming these homo-oligomeric bundles [1].	2010-10-14 10:24:07	2010-10-14 11:24:07	2	0	44	2301	7226	1
+501	CL0501	Gram-pos_anchor		Cell wall anchoring	Coggill P	pcc	This superfamily is characterised by families involved in the various mechanisms by which listerial proteins are attached at the bacterial surface and their many functions, including peptidoglycan metabolism, protein processing, adhesion to host cells, and invasion of host tissues.	2010-10-26 16:08:05	2010-10-26 17:08:05	2	20	882	1222	13906	1
+502	CL0502	STAS		STAS domain superfamily	Bateman A	agb	This superfamily includes proteins that have a STAS domain.	2010-10-28 16:36:18	2010-10-28 17:36:18	2	44	161	3695	13648	1
+503	CL0503	SOR		Superoxide reductase-like superfamily	Bateman A	agb	According to SCOP this superfamily includes the superoxide reductase domain as well as the C-terminal domain of desulfoferrodoxin.	2010-11-08 17:40:12	2010-11-08 17:40:12	2	55	13	767	1038	1
+504	CL0504	Phage_barrel		Phage tail beta-barrel superfamily	Bateman A	agb	This superfamily consists of a variety of bacteriophage protein families. Structurally members of this family contain a beta barrel.	2010-11-22 16:23:10	2010-11-22 16:23:10	2	18	106	2048	9306	1
+505	CL0505	Pentapeptide		Pentapeptide repeat	Bateman A	agb	This clan includes proteins that form a four sided parallel beta helix. They are generally compoased of pentapeptide repeat motifs.	2010-11-26 10:06:54	2010-11-26 10:06:54	2	43	484	2438	18381	1
+506	CL0506	Succ_CoA_synth		Succinyl-CoA synthetase flavodoxin domain superfamily	Bateman A	agb	This superfamily includes the flavodoxin like domain of succinyl-CoA synthetase and other related enzymes.	2010-12-02 12:48:20	2010-12-02 12:48:20	2	70	59	3740	11176	1
+507	CL0507	Fungal_trans		Fungal specific transcription factor domain	Bateman A	agb	This putative domain is found in fungal transcription factors.	2010-12-06 17:47:20	2010-12-06 17:47:20	2	0	306	239	14641	1
+508	CL0508	YkuD		L,D-transpeptidase catalytic domain	Bateman A	agb	This superfamily incldues the L,D-transpeptidase catalytic domain.	2010-12-08 12:28:21	2010-12-08 12:28:21	2	8	84	3166	11690	1
+509	CL0509	RBP11-like		RBP11-like subunits of RNA polymerase	Coggill P	pcc	This superfamily is characterised by all members carrying RNA Polymerase alpha subunit, chain A, domain 2. The member families form homo- and hetero-dimers.	2010-12-09 14:07:20	2010-12-09 14:07:20	2	280	32	6187	8189	1
+511	CL0511	Retroviral_zf		Retrovirus zinc finger-like domains	Coggill P	pcc	This superfamily has zinc-finger domains from GAG proteins, HIV nucleocapsids, nucleocapsid proteins from mason-pfizer monkey virus, and from other nucleic-acid binding proteins. Sometimes the domains appears in duplicate.	2011-01-17 16:09:42	2011-01-17 16:09:42	2	46	796	752	52586	1
+512	CL0512	CRAL_TRIO		CRAL-TRIO domain superfamily	Bateman A	agb	This superfamily includes the CRAL-TRIO domain.	2011-01-21 18:16:17	2011-01-21 18:16:17	2	28	141	377	5546	1
+513	CL0513	LCCL-domain		LCCL-domain like	Coggill P	pcc	This superfamily is characterised by an unusual fold exemplified in PDB:1jbi. Vertebrate members are the cysteine-rich secretory protein LCCL domain-containing proteins including Colchin. The fungal members are found to be necessary for histone de-acetylation.	2011-01-28 14:34:24	2011-01-28 14:34:24	2	1	51	235	1023	1
+515	CL0515	LTXXQ-like		LTXXQ-like superfamily	Coggill P	pcc	This is a superfamily of members all carrying the repeated LTxxQ paired sequence-motif region.	2011-02-10 14:04:19	2011-02-10 14:04:19	2	36	8	1376	2943	1
+516	CL0516	ISP-domain		Rieske-like iron-sulphur domain	Coggill P	pcc	This superfamily is characterised by Rieske Iron-sulfur families of the [2Fe-2S] type including NADH-nitrite reductase small subunit NirD proteins. This domain has an all-beta rubredoxin-like fold.	2011-02-14 16:52:53	2011-02-14 16:52:53	2	328	118	3882	14974	1
+517	CL0517	MBOAT-like		Membrane-bound O-acyltransferase,MBOAT,superfamily	Coggill P	pcc	This is a large superfamily of different enzymes. All biochemically characterised members of the superfamily encode enzymes that transfer organic acids, typically fatty acids, onto hydroxyl groups of membrane-embedded targets.	2011-02-16 11:16:11	2011-02-16 11:16:11	2	0	40	2323	5182	1
+520	CL0520	Keratin_assoc		Keratin_associated superfamily	Coggill P	pcc	Families in this clan are cysteine-rich and are from proteins associated with Keratin.	2011-03-09 11:23:29	2011-03-09 11:23:29	2	0	33	65	2969	1
+521	CL0521	GOLD-like		Sec14-like superfamily of golgi trafficking	Coggill P	pcc	This superfamily is characterised by proteins with a sandwich structure of 8 strands in 2 sheets as a jelly-roll.  The structure has similarity to the Nucleoplasmin-like/VP fold. The members are all involved in golgi trafficking.	2011-03-21 16:36:53	2011-03-21 16:36:53	2	5	40	359	2519	1
+522	CL0522	YbjQ-like		YbjQ-like superfamily	Coggill P	pcc	This superfamily is characterised by chains that form pentamers. Family structures are beta/alpha-propellers with additional short beta-strands that promote oligomeric assembly. Family members appear to be heavy-metal binding proteins.	2011-05-13 14:50:08	2011-05-13 15:50:08	2	25	7	1982	2593	1
+523	CL0523	GAG-polyprotein		LTR-copia-type polyprtien segments	Coggill P	pcc	This superfamily is characterised by family members that ar derived from retrotransposons of the copia-type.	2011-05-13 16:31:38	2011-05-13 17:31:38	2	0	851	262	10309	1
+524	CL0524	MPT63-MPB63		Antigen MPT63/MPB63 (immunoprotective extracellular	Coggill P	pcc	This superfamily is characterised by extracellular proteins with immuno-protectivce receptor domains on their surfaces resembling Ig domains. These are putative lipoproteins.	2011-05-23 13:54:12	2011-05-23 14:54:12	2	5	23	844	1193	1
+525	CL0525	pap2		Acid phosphatase/Vanadium-dependent haloperoxidase	Coggill P	pcc	The PAP2 superfamily is characterised by being mult-helical, with the core consisting of a 5-helical bundle. Normally the family will bind cofactor at the beginning of the third helix. The superfamily includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.	2011-06-02 14:59:14	2011-06-02 15:59:14	2	44	106	4454	15593	1
+526	CL0526	SUKH		SUKH superfamily	Zhang D, Iyer LM, Aravind L	la_psag	SUKH superfamily unites a diverse group of proteins including  Smi1/Knr4, PGs2, Fbxo3, Skip16, Syd, herpesviral US22, IRS1 and TRS1, and their bacterial homologs [1].	2011-07-18 20:15:40	2011-07-18 21:15:40	2	8	49	1725	4317	1
+527	CL0527	Sm-like		Sm (Small RNA binding protein domain)	Anantharaman V	la_psag	Conserved domain of core RNA-binding proteins of mRNA splicing and rRNA processing complexes, with a SH3-like Beta-barrel	2011-09-10 05:20:17	2011-09-10 06:20:17	2	515	85	2737	9033	1
+528	CL0528	DUF1214		DUF1214-like	Finn RD	rdf	Members of this clan usually appear in pairs on the same sequence. In cases where there is only a single example of the domain, there is often a second protein containing a single domain that is located sequentially along the chromosome. The crystal structure of pdb:2P3Y reveals that Pfam:PF06863 and Pfam:PF06742 come together to from a deep, positively charged pocket or cleft.  Structural comparisons reveal that this may this pocket that may bind some form of carbohydrate. Conserved residues are predominantly found on the surface of the positively charged cleft [Jayaraman et al. personal communication].	2011-09-23 21:21:03	2011-09-23 22:21:03	2	9	15	656	2556	1
+529	CL0529	FMN-dep-NRtase		FMN-dependent nitroreductase-like	Coggill P	pcc	This superfamily is involved in the reduction of nitrogen containing compounds. Members of this family utilise FMN as a cofactor and are often found to be homodimers. Possible characteristics include Oxygen-insensitive NAD(P)H nitroreductase (FMN-dependent nitroreductase) (Dihydropteridine reductase) and NADH dehydrogenase. A number of the proteins are described as oxidoreductases. They are primarily found in bacterial lineages though a number of eukaryotic homologues have been identified: Caenorhabditis elegans, Drosophila melanogaster, mouse and human. These protein are not found in photosynthetic eukaryotes; sequences containing this entry in photosynthetic organisms are possible false positives.	2011-11-17 15:49:14	2011-11-17 15:49:14	1	206	111	4539	16601	1
+530	CL0530	DNase_I-like		DNase I-like	Coggill P	pcc	This superfamily is characterised by members with an alpha-beta four-layer sandwich structure. It includes DNase I-like families of DNA-repair enzyme exonuclease III, DNA repair endonucleases, deoxyribonuclease I, endonuclease domain of retro-transposons. It also includes families of inositol polyphosphatases and shingomyelins-phosphodiesterases.	2011-11-29 11:19:36	2011-11-29 11:19:36	1	148	496	4823	22404	1
+531	CL0531	AMP-binding_C		AMP-binding enzyme C-terminal domain superfamily	Eberhardt R	re3	This superfamily contains domains found at the C-terminus of AMP-binding enzyme.	2011-12-02 13:00:41	2011-12-02 13:00:41	1	111	1767	5099	46854	1
+532	CL0532	LIG		Lipid-binding Ig-like superfamily	Bateman A	agb	This superfamily includes a number of lipid binding families that have a similar topology to the immunoglobulin fold. The family includes The ML domain Pfam:PF02221. It includes the uncharacterised family Pfam:PF06477.	2011-12-21 10:45:29	2011-12-21 10:45:29	1	68	32	336	2678	1
+533	CL0533	PRTase-like		PRPP synthetase-associated protein 1 	Coggill P	pcc	This superfamily of phosphoribosyl-transferases (PRTases) and phosphoribosyl-pyrophosphate synthetase-like protein families is characterised by a core fold of three layers, a/b/a with a mixed beta-sheet of six strands. In one of the families consists of two domains of this fold.	2012-01-09 11:27:00	2012-01-09 11:27:00	1	392	122	5229	42734	1
+534	CL0534	YjgF-like		YjgF-like superfamily	Coggill P	pcc	This superfamily is characterised by proteins that form trimers with three closely packed beta-sheets. Some member proteins are chorismate mutases, others are endoribonucleases active on single-stranded mRNA. It is the highly conserved YjgF/YER057c/UK114 protein superfamily. Homologues of this protein occur in eubacteria, archaea, and eukaryotes. Proteins are functionally diverse and are involved in a variety of enzymatic and non-enzymatic functions. The high sequence and structural similarity between members of this protein superfamily offer an example of minimalistic changes leading to functional diversification. This feature is best exemplified by the three close homologues of YjgF proteins in mammals (human, rat, and goat) with sequence identity better than 85%. These homologues perform different functions, including tumour antigen activity in the goat homologue, translation inhibition in the human and rat homologues (hp14.5 and rp14.5), endoribonuclease activity in rp14.5, calpain activation in the bovine homologue, molecular chaperone activity in DUK114, and involvement in the regulation of purine and removal of toxic metabolites in YjgF7, and involvement in isoleucine biosynthetic pathways (YjgF, YER057c, Ibm1). In addition, members of this protein family have also been shown to regulate mitochondrial maintenance (Ibm1) in yeast. Proteins from the YjgF family in plants are involved in photosynthesis and chromoplastogenesis (CHRD).	2012-01-18 11:20:47	2012-01-18 11:20:47	1	251	69	4391	13028	1
+535	CL0535	CBM		Carbohydrate-binding superfamily	Coggill P	pcc	This clan includes families of two different carbohydrate binding modules, chitin- and cellulase-binders.	2012-01-23 14:31:27	2012-01-23 14:31:27	1	41	221	1097	3033	1
+536	CL0536	HEXAPEP		Hexapeptide repeat superfamily	Coggill P	pcc	This superfamily is characterised by superhelical turns made up of three short strands duplicated many times; the sequence hexapeptide repeats correspond to individual strands. These hexapeptide repeat regions occur in a range of transferase enzymes.	2012-01-23 14:56:06	2012-01-23 14:56:06	1	380	348	5071	79539	1
+537	CL0537	CCCH_zf		CCCH-zinc finger	Coggill P	pcc	This superfamily is characterised by families of proteins with several Cys3His zinc-binding domains in tandem.	2012-01-26 16:19:39	2012-01-26 16:19:39	1	17	263	457	8803	1
+538	CL0538	DRMIP-like		MAPK-interacting Drmip-like superfamily	Coggill P	pcc	This superfamily contains members that are similar to the MAPK-interacting DRMIP-like family.	2012-02-01 16:26:27	2012-02-01 16:26:27	1	0	20	175	786	1
+539	CL0539	RNase_III		RNase III domain-like superfamily	Coggill P	pcc	This superfamily is characterised structurally by having a core of 5 helices where one of the helices is surrounded by the others.  Many members have the endonuclease catalytic domain.	2012-02-06 18:13:43	2012-02-06 18:13:43	1	62	100	4733	7980	1
+540	CL0540	GCP		Gamma-tubulin complex superfamily	Coggill P	pcc	This superfamily carries families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome.	2012-02-09 14:22:48	2012-02-09 14:22:48	1	1	23	316	1604	1
+541	CL0541	SH2-like		SH2, phosphotyrosine-recognition domain superfamily	Coggill P	pcc	This superfamily is characterised by proteins with the SH2-like fold. The proesence of this domain guides signal-transduction towards the phosphorylated tyrosine residues on its interacting protein-partner.	2012-02-21 16:19:05	2012-02-21 16:19:05	1	387	421	453	9393	1
+542	CL0542	RAS_GEF_N		Ras guanyl-nucleotide exchange factor activity N-term	Coggill P	pcc	This is the more N-terminal domain of the RAS-GEF superfamily.	2012-02-29 11:57:43	2012-02-29 11:57:43	1	14	157	277	2682	1
+543	CL0543	Viral_gly_cn_dm		Viral glycoprotein central and dimerisation domains	Eberhardt R	re3	Flavivirus and alpha virus glycoprotein E/E1 consists of three domains. A dimerisation domain, a central domain and an immunoglobulin-like domain. The dimerisation and central domains are intertwined [1-3].	2012-03-23 15:37:00	2012-03-23 15:37:00	1	93	37	200	12815	1
+544	CL0544	AcylCoA_ox_dh_N		Acyl-coenzyme A oxidase/dehydrogenase N-terminal	Eberhardt R	re3	Acyl-CoA dehydrogenases and acyl-coenzyme A oxidases consist of three domains. An N-terminal all alpha domain, a beta-barrel middle domain and a C-terminal catalytic domain [1-2].	2012-03-27 08:17:33	2012-03-27 09:17:33	1	223	112	3478	26792	1
+545	CL0545	APCOP-app_sub		Clathrin (AP) and COPI appendage platform  subdomain	Coggill P	pcc	This superfamily is characterised by subdomains from the clathrin and coatomer appendages. The superfamily possesses a single protein/protein interaction site that in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2 [1].	2012-04-18 13:17:34	2012-04-18 14:17:34	1	0	11	303	446	1
+546	CL0546	Hexosaminidase		beta-N-acetylhexosaminidase-like domain	Coggill P	pcc	This superfamily is characterised by a mixed beta sheet with connection over the free side of the sheet. The fold is like a zincin fold lacking the catalytic centre.	2012-04-30 14:53:24	2012-04-30 15:53:24	1	124	150	1212	3278	1
+547	CL0547	GF_recep_C-rich		Growth factor receptor Cys-rich	Eberhardt R	re3	The cysteine-rich regions of growth factor receptor tyrosine kinases consist of eight disulphide-linked modules [1].	2012-05-01 09:19:56	2012-05-01 10:19:56	1	49	88	140	2125	1
+548	CL0548	IHF-likeDNA-bdg		IHF-like DNA-binding protein supewrfamily	Coggill P	pcc	This superfamily is characterised by being a dimer of identical subunits of a core of four helices in a bundle, partly opened, capped with a beta-sheet. All members appear to be prokaryotic DNA-binding domains.	2012-05-01 16:00:04	2012-05-01 17:00:04	1	60	13	4459	12213	1
+549	CL0549	NicO_HupE_DsbD		NicO/HupE/DsdD superfamily	Eberhardt R	re3	This clan contains the nickel transpot family NicO [1-2] and the HupE/UreJ proteins, which may be involved in nickel binding. NicO and HupE contain a conserved GxxHxxxDH motif, which may bind to nickel.	2012-05-31 10:50:16	2012-05-31 11:50:16	1	0	55	3953	10451	1
+550	CL0550	SRCR		SRCR-like	Eberhardt R	re3		2012-07-11 13:20:22	2012-07-11 14:20:22	1	19	402	139	9451	1
+551	CL0551	BCLiA		Bcl-2 inhibitors of programmed cell death	Coggill P	pcc	This superfamily is characterised by families of proteins that inhibit apoptosis, They are regulated by all BH3-only proteins to promote apoptosis.	2012-08-31 14:55:14	2012-08-31 15:55:14	1	151	28	348	1402	1
+552	CL0552	Hect		Hect, E3 ligase catalytic domain	Coggill P	pcc	This superfamily is characterised by fmailies with E3-ligase catalytic acitvity.  The fold consists of two alpha+beta domains; where the N-terminal domain is an array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit.	2012-09-07 15:42:50	2012-09-07 16:42:50	1	23	249	342	4684	1
+553	CL0553	HBMR		Helical backbone metal receptor superfamily	Coggill P	pcc	This superfamily is characterised by a long alpha helical insertion in the interdomain linker in the Chelatase-like fold. Representative families include the periplasmic ferric siderophore binding proteins, the TroA-like nitrogenase iron-molybdenum proteins and the putative iron(III) transporter family, TM0189-like, or periplasmic-binding family.	2012-09-12 10:08:39	2012-09-12 11:08:39	1	190	51	4828	19772	1
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/f1
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/f1	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,14831 @@
+PF00389 2-Hacid_DH; <br>D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. This family represents the largest portion of the catalytic domain  of 2-hydroxyacid dehydrogenases as the NAD binding domain is  inserted within the structural domain.. 
+PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain)<br>These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.. 
+PF04029 2-phosphosulpholactate phosphatase<br>Thought to catalyse 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor.  Involved in the second step of coenzyme M biosynthesis.  Inhibited by vanadate in Methanococcus jannaschii.  Also known as the ComB family  .. 
+PF03171 2OG-Fe(II) oxygenase superfamily<br>This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily  .  This family includes the C-terminal of prolyl 4-hydroxylase  alpha subunit.  The holoenzyme has the activity EC:1.14.11.2  catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2.  The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site  . The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.. 
+PF01073 3-beta hydroxysteroid dehydrogenase/isomerase family<br>Pfam-B_504 (release 3.0). The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene  isomerase (3 beta-HSD) catalyses the oxidation and isomerisation  of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene  steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.. 
+PF04419 4F5 protein family<br>Members of this family are short proteins that are rich in aspartate, glutamate, lysine and arginine. Although the function of these proteins is unknown, they are found to be ubiquitously expressed  .. 
+PF03061 Thioesterase superfamily<br>Pfam-B_2758 (release 6.4). This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the  biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA  thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other  long chain fatty acyl-CoA thioesters.. 
+PF02872 5_nucleotidaseC; <br>5'-nucleotidase, C-terminal domain. Pfam-B_1318 (release 3.0). 
+PF00003 7 transmembrane sweet-taste receptor of 3 GCPR<br>This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G Pfam:PF07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor Pfam:PF01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness  .. 
+PF01661 DUF27;A1pp; <br>Pfam-B_434 (release 4.1). This domain is an ADP-ribose binding module.  It is found in a number of otherwise unrelated proteins.  It is found at the C-terminus of the macro-H2A histone protein Swiss:Q02874. This domain is found in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alphaviruses Swiss:P03317. This domain is also found on its own in a family of proteins from bacteria Swiss:P75918, archaebacteria Swiss:O59182 and eukaryotes Swiss:Q17432.. 
+PF02177 A4_EXTRA;<br>Amyloid A4 N-terminal heparin-binding. Alignment kindly provided by SMART. This N-terminal domain of APP, amyloid precursor protein, is the heparin-binding domain of the protein. this region is also responsible for stimulation of neurite outgrowth. The structure reveals both a highly charged basic surface that may interact with glycosaminoglycans in the brain and an abutting hydrophobic surface that is proposed to play an important functional role such as in dimerisation or ligand-binding. Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggest the APP N-terminal domain could function as a growth factor in vivo  .. 
+PF00962 Adenosine/AMP deaminase<br>
+PF01490 Transmembrane amino acid transporter protein<br>Pfam-B_419 (release 4.0). This transmembrane region is found in many amino acid transporters  including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane  domains Swiss:P34579  . MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance Swiss:P38680. Other members of this family include proline transporters and amino acid permeases.. 
+PF00004 ATPase family associated with various cellular activities (AAA)<br>AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes  .. 
+PF00696 aakinase; <br>Amino acid kinase family. Pfam-B_100 (release 2.1). This family includes kinases that phosphorylate a variety of amino acid substrates, as well as uridylate kinase and carbamate kinase. This family includes: Aspartokinase EC:2.7.2.4, Swiss:P00561. Acetylglutamate kinase EC:2.7.2.8, Swiss:Q07905. Glutamate 5-kinase EC:2.7.2.11, Swiss:P07005. Uridylate kinase EC:2.7.4.-, Swiss:P29464. Carbamate kinase EC:2.7.2.2, Swiss:O96432.. 
+PF03109 ABC1 family<br>Pfam-B_339 (release 6.5). This family includes ABC1 from yeast   and AarF from E. coli  . These proteins have a nuclear or mitochondrial  subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex   and E. coli AarF is required for ubiquinone production  . It has been  suggested that members of the ABC1 family are novel chaperonins  . These proteins are unrelated to the ABC transporter proteins.. 
+PF01842 ACT domain<br>This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.  The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine  . Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585. 
+PF04083 abhydro_lipase; <br>Partial alpha/beta-hydrolase lipase region. Pfam-B_267 (release 7.3);. This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.. 
+PF00583 Acetyltransf; <br>Acetyltransferase (GNAT) family. MRC-LMB Genome group. This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.. 
+PF01648 4'-phosphopantetheinyl transferase superfamily<br>Pfam-B_1679 (release 4.1) & Pfam-B_3672 (Release 7.5). Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP  . This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known  , which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.. 
+PF01064 Activin types I and II receptor domain<br>Pfam-B_338 (release 3.0). This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich  ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.. 
+PF00441 Acyl-CoA_dh;<br>Acyl-CoA dehydrogenase, C-terminal domain. C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.. 
+PF01757 DUF33;<br>Acyltransferase family. Pfam-B_708 (release 4.2). This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterised C. elegans proteins and it is approximately 300 amino acids long.. 
+PF00928 Adaptor complexes medium subunit family<br>Pfam-B_1007 (release 3.0). This family also contains members which are coatomer subunits.. 
+PF00107 adh_zinc; <br>Zinc-binding dehydrogenase. 
+PF02682 DUF213; <br>Allophanate hydrolase subunit 1. This family is the first subunit of allophanate hydrolase.. 
+PF03915 Actin interacting protein 3<br>Wood V, Griffiths-Jones SR. Pfam-B_38461 (release 7.2). 
+PF00842 Ala_racemase; <br>Alanine racemase, C-terminal domain. Pfam-B_1496 (release 2.1). 
+PF01168 UPF0001;<br>Alanine racemase, N-terminal domain. 
+PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain<br>
+PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase<br>
+PF00248 aldo_ket_red; <br>Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity  .. 
+PF01263 Aldose 1-epimerase<br>
+PF03155 ALG6, ALG8 glycosyltransferase family<br>Pfam-B_3941 (release 6.5). N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid  (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one  . In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147  .. 
+PF00245 alk_phosphatase; <br>Alkaline phosphatase. 
+PF02806 alpha-amylase_C; <br>Alpha amylase, C-terminal all-beta domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the  active site, interrupted by a ~70 a.a. calcium-binding domain  protruding between beta strand 3 and alpha helix 3, and a  carboxyl-terminal Greek key beta-barrel domain.. 
+PF05111 Ameloblastin precursor (Amelin)<br>Pfam-B_6419 (release 7.7). This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and  sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which  is though to have a role in determining the prismatic structure of growing enamel crystals  .. 
+PF01510 N-acetylmuramoyl-L-alanine amidase<br>Pfam-B_735 (release 4.0). This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala).  The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.. 
+PF01520 N-acetylmuramoyl-L-alanine amidase<br>Pfam-B_888 (release 4.0). This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.. 
+PF01593 Flavin containing amine oxidoreductase<br>Pfam-B_606 (release 4.1)b. This family consists of various amine oxidases, including maze polyamine oxidase (PAO)   and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines  . In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium  . PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines  .  Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.. 
+PF00501 AMP-binding enzyme<br>
+PF05195 Aminopeptidase P, N-terminal domain<br>This domain is structurally very similar   to the creatinase N-terminal domain (Pfam:PF01321). However, little or no sequence similarity exists between the two families.. 
+PF03098 Animal haem peroxidase<br>
+PF01821 Anaphylotoxin-like domain<br>C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.. 
+PF01094 Receptor family ligand binding region<br>This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.. 
+PF00023 ank; <br>Swissprot_feature_table. Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity   .. 
+PF00191 annexin; <br>This family of annexins also includes giardin that has been shown to function as an annexin  .. 
+PF03861 ANTAR domain<br>ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the  domain consists of a coiled-coil. . 
+PF04729 Anti-silence; <br>ASF1 like histone chaperone. Pfam-B_3167 (release 7.5). This family includes the yeast and human ASF1 protein.  These proteins have histone chaperone activity  .  ASF1 participates in both the replication-dependent and replication-independent pathways.  The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers  .. 
+PF02822 Antistasin family<br>Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.. 
+PF00847 AP2-domain; <br>Pfam-B_409 (release 3.0). This 60 amino acid residue domain can bind to DNA   and is found in transcription factor proteins.. 
+PF02424 ApbE family<br>Pfam-B_1963 (release 5.4). This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis  . More specifically is may be involved in the conversion of aminoimidazole ribotide (AIR) to 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP).. 
+PF04049 Anaphase promoting complex subunit 8 / Cdc23 <br>Pfam-B_13808 (release 7.3);. The anaphase-promoting complex is composed of eight protein  subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6),  and CDC23 (APC8).. 
+PF04106 Autophagy protein Apg5 <br>Pfam-B_12134 (release 7.3);. Apg5 is directly required for the import of  aminopeptidase I via the cytoplasm-to-vacuole targeting  pathway  .. 
+PF04602 arab_transf; <br>Mycobacterial cell wall arabinan synthesis protein. Pfam-B_4670 (release 7.5). Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the   macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol  .. 
+PF03079 ARD/ARD' family<br>Pfam-B_2276 (release 6.4). The two acireductone dioxygenase enzymes (ARD and ARD', previously known as E-2 and E-2') from Klebsiella pneumoniae share the same amino acid sequence  Swiss:Q9ZFE7, but bind different metal ions: ARD binds Ni2+, ARD' binds Fe2+. ARD and ARD' can be experimentally interconverted by removal of the bound metal ion and reconstitution with the appropriate metal ion.  The two enzymes share the same substrate, 1,2-dihydroxy-3-keto-5-(methylthio)pentene, but yield different products. ARD' yields the alpha-keto precursor of methionine (and formate), thus forming part of the ubiquitous methionine salvage  pathway that converts 5'-methylthioadenosine (MTA) to methionine. This pathway is responsible for the tight control of the concentration of MTA, which is a powerful inhibitor of polyamine biosynthesis and transmethylation reactions [1,2]. ARD yields methylthiopropanoate, carbon monoxide and formate, and thus prevents the conversion of MTA to methionine. The role of the ARD catalysed reaction is unclear: methylthiopropanoate is cytotoxic, and carbon monoxide can activate guanylyl cyclase, leading to increased intracellular cGMP levels [1,2]. This family also contains other members, whose functions are not well characterised.. 
+PF01412 Putative GTPase activating protein for Arf<br>Ponting CP, Schultz J, Bork P. Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.. 
+PF01388 ARID/BRIGHT DNA binding domain<br>This domain is know as ARID for AT-Rich Interaction Domain  , and also known as the BRIGHT domain  .. 
+PF04683 ARM_1; <br>Proteasome complex subunit Rpn13 ubiquitin receptor. Pfam-B_4497 (release 7.5). This family was thought originally to be involved in cell-adhesion [1,2], but the members are now known to be proteasome subunit Rpn13, a novel ubiquitin receptor. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain  . The domain forms two contiguous anti-parallel beta-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold  . Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37  .. 
+PF00514 Armadillo_seg; <br>Armadillo/beta-catenin-like repeat. Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.. 
+PF00339 arrestin; <br>Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold.  Scop reports duplication with C-terminal domain.. 
+PF02752 arrestin_C; <br>Arrestin (or S-antigen), C-terminal domain. Ig-like beta-sandwich fold.  Scop reports duplication with N-terminal domain.. 
+PF04959 Arsenite-resistance protein 2<br>Pfam-B_5269 (release 7.6). Arsenite is a carcinogenic compound which can act as a co-mutagen by  inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance  .. 
+PF01037 ASNC_trans_reg; <br>Pfam-B_773 (release 3.0). The AsnC family is a family of similar bacterial transcription regulatory  proteins.. 
+PF05118 Aspartyl/Asparaginyl beta-hydroxylase<br>Pfam-B_2775 (release 7.7). Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes.  Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure of proline 3-hydroxylase contains the conserved motifs present in other 2-OG oxygenases including a jelly roll strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within the extended family.  This family represent the arginine, asparagine and proline hydroxylases. The aspartyl/asparaginyl beta-hydroxylase (EC:1.14.11.16) specifically hydroxylates one aspartic or asparagine residue in certain epidermal growth factor-like domains of a number of proteins  .. 
+PF01177 Asp/Glu/Hydantoin racemase<br>This family contains aspartate racemase, maleate isomerases EC:5.2.1.1  , glutamate racemase, hydantoin racemase and arylmalonate decarboxylase EC:4.1.1.76  .. 
+PF01400 Astacin (Peptidase family M12A)<br>The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3.  Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain.  All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin Swiss:P07584, a digestive enzyme from Crayfish. Meprin, Swiss:Q16819, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila Swiss:P25723.. 
+PF02178 AT hook motif<br>Alignment kindly provided by SMART. At hooks are DNA binding motifs with a preference for A/T rich regions.. 
+PF03029 ATP-bind; <br>Conserved hypothetical ATP binding protein. Pfam-B_1301 (release 6.4) & Pfam-B_2154 (Release 8.0). Members of this family are found in a range of archaea and eukaryotes and have hypothesised ATP binding activity.. 
+PF00306 ATP synthase alpha/beta chain, C terminal domain<br>Pfam-B_15 (release 1.0). 
+PF02874 ATP synthase alpha/beta family, beta-barrel domain<br>This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.. 
+PF04718 ATPsynth_g; <br>Mitochondrial ATP synthase g subunit. Pfam-B_5977 (release 7.5). The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport.  It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L). The function of subunit g is currently unknown.  The conserved region covers all but the very N-terminus of the member sequences. No prokaryotic members have been identified thus far  .. 
+PF03768 Attacin, N-terminal region<br>Pfam-B_2791 (release 7.0). This family includes attacin and sarcotoxin, but not  diptericin (which share similarity to the C-terminal region of attacin).  All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically  to kill the invading microorganism  .. 
+PF03797 Autotransporter beta-domain<br>Secretion of protein products occurs by a number of different pathways in bacteria.  One of these pathways known as the type V pathway was first described for the IgA1 protease  . The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in.  The N terminus contains the variable passenger domain that is translocated across the membrane.  Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs  .. 
+PF03547 Auxin_eff; <br>Membrane transport protein. TIGRFAMs, Griffiths-Jones SR. TIGRFAMs & Pfam-B_5261 (Release 7.5). This family includes auxin efflux carrier proteins and other transporter proteins from all domains of life.. 
+PF02310 B12 binding domain<br>Pfam-B_359 (release 5.2). This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding  .. 
+PF02607 B12 binding domain<br>This B12 binding domain is found in methionine synthase EC:2.1.1.13 Swiss:Q99707, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of Pfam:PF02310. The structure of this domain is known  , it is a  4 helix bundle. Many of the conserved residues in this domain are involved in B12 binding, such as those in the MXXVG motif.. 
+PF02362 B3 DNA binding domain<br>Pfam-B_582 (release 5.2). This is a family of plant transcription factors with various roles in development, the aligned region corresponds the B3 DNA binding domain as described in   this domain is found in VP1/AB13 transcription factors  .  Some proteins also have a second AP2 DNA binding domain Pfam:PF00847 such as RAV1 Swiss:Q9ZWM9  . DNA binding activity was demonstrated by  .. 
+PF01313 Bacterial export proteins, family 3<br>Pfam-B_898 (release 3.0). This family includes the following members;     FliQ, MopD, HrcS, Hrp, YopS and SpaQ All of these members export proteins, that do not possess signal  peptides, through the membrane.  Although the proteins that these exporters move may be different, the exporters are thought to  function in similar ways  .. 
+PF02673 Bacitracin resistance protein BacA<br>Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol  .. 
+PF01011 Bacterial_PQQ;<br>Pfam-B_1319 (release 3.0). The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilise pyrrolo-quinoline quinone as a prosthetic group.. 
+PF03704 BAD; <br>Bacterial transcriptional activator domain. Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR (Swiss:P25941) along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.. 
+PF01426 BAH domain<br>This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction  .. 
+PF01145 SPFH domain / Band 7 family<br>This family has been called SPFH  , Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.. 
+PF03594 Benzoate membrane transport protein<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02944 BESS motif<br>The BESS motif is named after the proteins in which it is found (BEAF  , Suvar(3)7   and Stonewall  ). The motif is 40 amino acid residues long and is composed of two predicted alpha helices. Based on the protein in which it is found and the presence of conserved positively charged residues it is predicted to be a DNA binding domain. This domain appears to be specific to drosophila.. 
+PF02369 Bacterial Ig-like domain (group 1)<br>This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity. . 
+PF02785 Biotin carboxylase C-terminal domain<br>Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step  in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference   are in  this C-terminal domain.. 
+PF02012 BNR/Asp-box repeat<br>Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in many glycosyl hydrolases as well as other extracellular proteins of unknown function.. 
+PF00528 BPD_transp; <br>Binding-protein-dependent transport system inner membrane component. LMB bacterial genome group and Prosite. The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.. 
+PF02237 Biotin protein ligase C terminal domain<br>The function of this structural domain is unknown.  It is found to the C terminus of the biotin protein ligase catalytic domain Pfam:PF01317. . 
+PF03099 BPL_LipA_LipB; <br>Biotin/lipoate A/B protein ligase family. This family includes biotin protein ligase, lipoate-protein ligase A and B.  Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites.  Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organism probably has only one BPL.  Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine  . Lipoate-protein ligase A (LPLA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes  . The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor  .. 
+PF02485 Core-2/I-Branching enzyme<br>Pfam-B_842 (release 5.4). This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme (eg Swiss:Q06430) and core-2 branching enzyme (eg Swiss:Q02742). I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development  . Core-2 branching enzyme forms crucial side-chain branches in  O-glycans  .. 
+PF00533 BRCA1 C Terminus (BRCT) domain<br>
+PF04089 BRICHOS domain<br>The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialised intracellular protease processing system  . This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, Pfam:PF08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region  .. 
+PF04427 Brix domain<br>
+PF03097 BRO1-like domain<br>This domain is found in a number proteins including Rhophilin Swiss:Q61085 and BRO1 Swiss:P48582.  It is known to have a role in endosomal targeting.  ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1  .. 
+PF00439 bromodomain; <br>Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine  .. 
+PF03909 BSD domain  <br>This domain contains a distinctive -FW- motif. It is found in a family  of eukaryotic transcription factors as well as a set of proteins of unknown function.. 
+PF03092 BT1 family<br>Pfam-B_1804 (release 6.4). Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants  , thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member  of this family) was previously noted  . This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted  prokaryotic proteins (from the cyanobacteria Synechocystis and  Synechococcus).. 
+PF00651 BTB/POZ domain<br>The BTB (for BR-C, ttk and bab)   or POZ (for Pox virus and Zinc finger)   domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation  . The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer.  The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule  . POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.. 
+PF03437 BtpA family<br>Pfam-B_4453 (release 6.6). The BtpA protein is tightly associated with the thylakoid membranes, where it stabilises the reaction centre proteins of photosystem I.. 
+PF03131 bZIP Maf transcription factor<br>Mifsud W, Eberhardt R. Pfam-B_482 (release 6.5). Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property  . Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].. 
+PF00168 C2 domain<br>Swissprot_feature_table. 
+PF02743 Cache; <br>
+PF04857 CAF1 family ribonuclease<br>Pfam-B_1567 (release 7.5). 
+PF03135 CagE, TrbE, VirB family, component of type IV transporter system<br>Pfam-B_843 (release 6.5). This family includes the Helicobacter pylori protein CagE  Swiss:Q48252, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system.  The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration  . Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro  . Similar type IV transport systems are also found in other bacteria. This family includes the TrbE Swiss:P54910 and VirB Swiss:P05353  proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. Homologues of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis Swiss:Q9RPY1.. 
+PF02515 CAIB-BAIF;<br>CoA-transferase family III. Pfam-B_887 (release 5.4). CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.. 
+PF02888 Calmodulin binding domain<br>Psi-blast P70604/413-489. Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM)  . CaM binds to the SK channel through this the CaM-binding domain (CaMBD), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca2+ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known  . This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other.. 
+PF01302 CAP-Gly domain<br>Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein Swiss:Q20728 CAP-Gly domain was recently solved  . The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove  .. 
+PF01039 Carboxyl transferase domain<br>Pfam-B_299 (release 3.0). All of the members in this family are biotin dependent carboxylases.  The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognised types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide.  All of the members in this family utilise acyl-CoA as the acceptor molecule.. 
+PF00755 Choline/Carnitine o-acyltransferase<br>Pfam-B_438 (release 2.1). 
+PF03378 CAS/CSE protein, C-terminus<br>Pfam-B_3786 (release 6.6). Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1  . This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation [2,3]. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation.  Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle  , as is the protein MEK, which is thought to regulate the intracellular localisation (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway  . The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins  . Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins  .. 
+PF00690 Na_K_ATPase_N; <br>Cation transporter/ATPase, N-terminus. Pfam-B_138 (release 2.1). Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.. 
+PF01545 Cation efflux family<br>Pfam-B_232 (release 4.0). Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.. 
+PF04586 Caudo_protease; <br>Caudovirus prohead protease. Pfam-B_4836 (release 7.5). Family of Caudovirus prohead proteases also found in a number of bacteria possibly as the result of horizontal transfer. . 
+PF01607 Chitin_bind_2; <br>Chitin binding Peritrophin-A domain. This domain is called the Peritrophin-A domain and is found in chitin binding proteins particularly peritrophic matrix proteins of insects and animal chitinases. Copies of the domain are also found in some baculoviruses. Relevant references that describe proteins with this domain include [1-3]. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains  .. 
+PF00942 Cellulose_bind; CBD_3; <br>Cellulose binding domain. Pfam-B_1126 (release 3.0). 
+PF02018 CBD_6; CBM_4; <br>Carbohydrate binding domain. This family includes diverse carbohydrate binding domains.. 
+PF03422 Carbohydrate binding module (family 6)<br>Pfam-B_1231 (release 6.6). 
+PF00571 CBS domain<br>
+PF02754 DUF224; <br>Cysteine-rich domain. The key element of this family is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins  . There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster  . The family includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase   Swiss:P52074 and glycerol-3-phosphate dehydrogenase.. 
+PF03379 CcmB protein<br>Pfam-B_3059 (release 6.6). CcmB is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. CcmB is required for the export of haem to the periplasm.. 
+PF04103 CD20-like family<br>Pfam-B_1979 (rel 7.3), Pfam-B_10092 (rel 9.0). This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm  . This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts  . This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton  .. 
+PF05179 Cdc73; <br>RNA pol II accessory factor, Cdc73 family. Pfam-B_6394 (release 7.7). 
+PF01066 CDP-alcohol phosphatidyltransferase<br>Pfam-B_651 (release 3.0). All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.. 
+PF00150 cellulase; <br>Cellulase (glycosyl hydrolase family 5). 
+PF04218 CENP-B N-terminal DNA-binding domain<br>Centromere Protein B (CENP-B) is a DNA-binding protein localised to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure  .. 
+PF04734 Neutral/alkaline non-lysosomal ceramidase<br>Pfam-B_3385 (release 7.5). This family represents a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes [1,2,3].. 
+PF03859 CG-1 domain<br>Pfam-B_18451 (Release 7.1). CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein  . CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs  .. 
+PF00307 actinin-binding; <br>Calponin homology (CH) domain. The CH domain is found in both cytoskeletal proteins and signal transduction proteins  .  The CH domain is involved in actin binding in some members of the family.  However in calponins there is evidence that the CH domain is not involved in its actin binding activity  .  Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin and Swiss:P15498 have only a single copy.. 
+PF04420 CHD5-like protein<br>Members of this family are probably coiled-coil proteins that are similar to the CHD5 (Congenital heart disease 5) protein. In Saccharomyces cerevisiae this protein localises to the ER and is thought to play a homeostatic role  .. 
+PF03067 Chitin binding domain<br>Pfam-B_2364 (release 6.4). This domain is found associated with a wide variety of cellulose binding domain. This domain however is a chitin binding domain. This domain is found in isolation in baculoviral spheroidins and spindolins, protein of unknown function.. 
+PF00379 insect_cuticle; <br>Insect cuticle protein. Many insect cuticular proteins include a 35-36 amino acid motif known as the R&R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region  . Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD)  .. 
+PF04968 CHORD <br>Pfam-B_1217 (release 7.0). CHORD represents a Zn binding domain. Silencing of the  C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of  the wild-type gene in nematode development  . . 
+PF02017 CIDE-N domain<br>This domain is found in CAD nuclease Swiss:O76075 , ICAD Swiss:O00273 the inhibitor of CAD nuclease. The two proteins interact through this domain.. 
+PF02487 CLN3 protein<br>Pfam-B_1060 (release 5.4). This is a family of proteins from the CLN3 gene. A missense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein (Swiss:Q13286) has been implicated in Juvenile neuronal ceroid  lipofuscinosis (Batten disease)  .. 
+PF02861 Clp amino terminal domain<br>Pfam-B_102 (release 6.0). This short domain is found in one or two copies at the amino terminus of ClpA and ClpB proteins from bacteria and eukaryotes. The function of these domains is uncertain but they may form a protein binding site  .. 
+PF02353 Mycolic acid cyclopropane synthetase<br>Pfam-B_862 (release 5.2). This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyse the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.. 
+PF00780 CNH domain<br>Alignment kindly provided by SMART. Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.. 
+PF00027 Cyclic nucleotide-binding domain<br>
+PF02629 DUF184; <br>This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.. 
+PF01144 Coenzyme A transferase<br>
+PF02514 cobN-Mg_chel; <br>CobN/Magnesium Chelatase. Pfam-B_647 (release 5.4). This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid  . Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis  .. 
+PF02492 CobW/HypB/UreG, nucleotide-binding domain<br>Pfam-B_428 (release 4.0) & Pfam-B_1247 (release 5.4). This domain is found in HypB, a hydrogenase expression / formation protein, and  UreG a urease accessory protein.  Both these proteins contain a P-loop nucleotide binding motif [2,3]. HypB has GTPase activity  and is a guanine nucleotide binding protein  . It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression  . UreG is required for functional incorporation of the urease nickel metallocenter.  GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins  . This family of domains also contains P47K (Swiss:P31521), a Pseudomonas  chlororaphis protein needed for nitrile hydratase expression, and the  cobW gene product (Swiss:P29937), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans  .. 
+PF00135 Carboxylesterase family<br>
+PF01484 Nematode cuticle collagen N-terminal domain<br>Pfam-B_200 (release 4.0). The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see Pfam:PF01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins  .. 
+PF01391 Collagen triple helix repeat (20 copies)<br>Members of this family belong to the collagen superfamily  . Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix.  The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline.  Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.. 
+PF03772 Competence protein<br>Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA [1,4]. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.. 
+PF05071 Complex1_17_2kD; <br>NADH ubiquinone oxidoreductase subunit NDUFA12. This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues.  The family also contains a second related eukaryotic protein of unknown function, e.g. Swiss:Q9BV02.. 
+PF00329 complex1_30Kd; <br>Respiratory-chain NADH dehydrogenase, 30 Kd subunit. 
+PF02950 Conotoxin<br>Pfam-B_529 (release 6.4). Conotoxins are small snail toxins that block ion channels.. 
+PF05019 Coenzyme Q (ubiquinone) biosynthesis protein Coq4<br>Pfam-B_14948 (release 7.6). Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway  .  The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).. 
+PF03471 Transporter associated domain<br>This small domain is found in a family of proteins with the Pfam:PF01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux.  The function of this domain is uncertain but might be involved in modulating transport of ion substrates.. 
+PF02389 Cornifin (SPRR) family<br>Pfam-B_1215 (release 5.2). SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid  . . 
+PF02628 Cytochrome oxidase assembly protein<br>This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus  subtilis  . COX15 is required for cytochrome c oxidase assembly in yeast (Swiss:P40086).. 
+PF02936 Cytochrome c oxidase subunit IV<br>Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium member of this family is called COX VI Swiss:P26310. The yeast protein Swiss:P53077 appears to be the yeast COX IV subunit.. 
+PF03626 Prokaryotic Cytochrome C oxidase subunit IV <br>Pfam-B_3217 (release 7.0). Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyses the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.. 
+PF02937 Cytochrome c oxidase subunit VIc<br>Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.. 
+PF02935 Cytochrome c oxidase subunit VIIc<br>Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII Swiss:P04039.. 
+PF04516 CP2 transcription factor<br>Pfam-B_2156 (release 7.5). This family represents a conserved region in the CP2 transcription factor family.. 
+PF00118 cpn60_TCP1; <br>TCP-1/cpn60 chaperonin family. This family includes members from the HSP60 chaperone family and  the TCP-1 (T-complex protein) family.. 
+PF02787 Carbamoyl-phosphate synthetase large chain, oligomerisation domain<br>Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  . 
+PF04969 CS domain<br>Pfam-B_1217 (release 7.0). The CS and CHORD (Pfam:PF04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD  . It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies  . Two CS domains are found at the C-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19) (Swiss:O94966), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2  .. 
+PF00988 Carbamoyl-phosphate synthase small chain, CPSase domain<br>Pfam-B_345 (release 3.0). The carbamoyl-phosphate synthase domain is in the amino terminus of  protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines  . The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00289. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.. 
+PF03178 CPSF A subunit region<br>Pfam-B_1224 (release 6.5). This family includes a region that lies towards the C-terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs  . The function of the aligned region is unknown but may be involved in RNA/DNA binding.. 
+PF00313 'Cold-shock' DNA-binding domain<br>
+PF04442 Cytochrome c oxidase assembly protein CtaG/Cox11<br>Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein.\.  In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre.  Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units  . The C terminal region of the protein is known to form a dimer.  Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae (Swiss:P19516).  Met 224 is also thought to play a role in copper transfer or stabilising the copper site  .. 
+PF01148 Cytidylyltrans; <br>Cytidylyltransferase family. Pfam-B_921 (release 3.0). The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast.  Sec59 is a dolichol kinase EC:2.7.1.108.. 
+PF04145 Ctr copper transporter family<br>Pfam-B_3006 (release 7.3). The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane.  A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.. 
+PF00394 Multicopper oxidase<br>Many of the proteins in this family contain multiple similar  copies of this plastocyanin-like domain.. 
+PF03712 Copper type II ascorbate-dependent monooxygenase, C-terminal domain<br>The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.. 
+PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain<br>The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.. 
+PF02845 CUE domain<br>Alignment kindly provided by SMART. CUE domains have been shown to bind ubiquitin [3-4]. It has been suggested that CUE domains are related to Pfam:PF00627   and this has been confirmed by the structure of the domain  . CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2  .. 
+PF00190 Seedstore_11s;Cupin; <br>This family represents the conserved barrel domain of the 'cupin' superfamily   ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins.  Plant seed storage proteins provide the major nitrogen source for the developing plant.. 
+PF04889 Cwf15/Cwc15 cell cycle control protein<br>Pfam-B_6589 (release 7.6). This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologues. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing  . . 
+PF04677 CwfJ_N_1; <br>Protein similar to CwfJ C-terminus 1. This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909).  CwfJ is part of the Cdc5p complex involved in mRNA splicing  .. 
+PF04676 CwfJ_N_2; <br>Protein similar to CwfJ C-terminus 2. This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909).  CwfJ is part of the Cdc5p complex involved in mRNA splicing  .. 
+PF01705 CX module<br>This domain has no known function. It is found in several C. elegans proteins. The domain contains 6 conserved cysteines that probably form three disulphide bridges.. 
+PF04673 cyclase_polyket; <br>Polyketide synthesis cyclase. Pfam-B_5596 (release 7.5). This family represents a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.. 
+PF00134 cyclin; <br>Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins  . Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.. 
+PF02276 Photosynthetic reaction centre cytochrome C subunit<br>Pfam-B_5109 (release 5.2). Photosynthesis in purple bacteria is dependent on light-induced electron transfer in the reaction centre (RC), coupled to the uptake  of protons from the cytoplasm. The RC contains a cytochrome molecule which re-reduces the oxidised electron donor.. 
+PF05038 cytochr_b558a; <br>Cytochrome Cytochrome b558 alpha-subunit. Pfam-B_5327 (release 7.7). Cytochrome b-245 light chain (p22-phox) is one of the key electron transfer elements of the NADPH oxidase in phagocytes  .. 
+PF01820 Dala_Dala_ligas; <br>D-ala D-ala ligase N-terminus. This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding  . D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF)  .. 
+PF01113 DapB; <br>Dihydrodipicolinate reductase, N-terminus. Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated  cyclic imine, dihydro-dipicolinate.  This reaction is the  second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both  protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.. 
+PF01682 DB module<br>This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig Pfam:PF00047 and fn3 Pfam:PF00041 domains, as well as in some lipases Pfam:PF00657.. 
+PF05011 Lariat debranching enzyme, C-terminal domain<br>Pfam-B_9676 (release 7.6). This presumed domain is found at the C-terminus of lariat debranching enzyme. This domain is always found in association with Pfam:PF00149.. 
+PF03107 DC1;<br>Pfam-B_16 (release 6.5). 
+PF00383 dCMP_cyt_deam;<br>Cytidine and deoxycytidylate deaminase zinc-binding region. 
+PF05026 Dcp2, box A domain<br>Pfam-B_10622 (release 7.6). This domain is always found to the amino terminal side of Pfam:PF00293.  This domain is specific to mRNA decapping protein 2 and this region has been termed Box A  .  Removal of the cap structure is catalysed by the Dcp1-Dcp2 complex  .. 
+PF03607 Doublecortin<br>
+PF03455 dDENN domain<br>This region is always found associated with Pfam:PF02141. It is predicted to form a globular domain  . This domain is predicted to be completely alpha helical. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family  .. 
+PF02791 DDT domain<br>The DDT domain is named after (DNA binding homeobox and Different  Transcription factors) and is approximately 60 residues in length   . Along with the WHIM motifs, it comprises an entirely alpha  helical module found in diverse eukaryotic chromatin proteins  .  Based on the structure of Ioc3, this module is inferred to  interact with nucleosomal linker DNA and the SLIDE domain of ISWI  proteins   . The resulting complex forms a protein ruler that  measures out the spacing between two adjacent nucleosomes  .  In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket  .. 
+PF00270 DEAD/DEAH box helicase<br>Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.. 
+PF00531 death; <br>
+PF04626 Dec-1 protein, C terminal region<br>The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing  . Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). Alternative splicing generates different carboxyl terminal ends in different protein isoforms, so this is region is the most C terminal region that is present in the main isoforms.. 
+PF02141 DENN (AEX-3) domain<br>DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways  .. 
+PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)<br>Ponting C, Schultz J, Bork P, Martemyanov K, Thorner J. The DEP domain   is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell [2-3]. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting [4-5]. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit [6-7].. 
+PF02272 DHHA1 domain<br>This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members  . This domains is also found in alanyl tRNA synthetase e.g. Swiss:P00957, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.. 
+PF04922 DIE2/ALG10 family<br>Pfam-B_9570 (release 7.6). The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterised in rat as potassium channel regulator 1  .. 
+PF01843 DIL domain<br>The DIL domain has no known function.. 
+PF03018 disease_resp; <br>Dirigent-like protein. Pfam-B_835 (release 6.4). This family contains a number of proteins which are induced during disease response in plants. Members of this family are involved in lignification.. 
+PF02377 Dishevelled specific domain<br>Pfam-B_1381 (release 5.2). This domain is specific to the signaling protein dishevelled. The domain is found adjacent to the PDZ domain Pfam:PF00595, often in conjunction with DEP (Pfam:PF00610) and DIX (Pfam:PF00778).. 
+PF02916 DNA polymerase processivity factor<br>
+PF01965 ThiJ; <br>The family includes the protease PfpI Swiss:Q51732  . This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. This N-terminal region of the full-length AdpA proteins is necessary for dimerisation of the molecule.. 
+PF00751 DM-domain; <br>DM DNA binding domain. The DM domain is named after dsx and mab-3  . dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains.  The DM domain has a pattern of conserved zinc chelating residues C2H2C4  . The dsx DM domain has been shown to dimerise and bind palindromic DNA  .. 
+PF01068 DNA_ligase; <br>ATP dependent DNA ligase domain. Pfam-B_788 (release 3.0). This domain belongs to a more diverse superfamily, including Pfam:PF01331 and Pfam:PF01653  .. 
+PF04679 ATP dependent DNA ligase C terminal region        <br>This region is found in many but not all ATP-dependent DNA ligase enzymes  (EC:6.5.1.1).  It is thought to constitute part of the catalytic core of ATP dependent DNA ligase  .. 
+PF04675 DNA ligase N terminus<br>This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1).  It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I (Swiss:P18858), and in Saccharomyces cerevisiae (Swiss:P04819), this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus (Swiss:P16272) this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation  .. 
+PF00875 DNA photolyase<br>Pfam-B_777 (release 3.0). This domain binds a light harvesting cofactor.. 
+PF00136 DNA polymerase family B<br>This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.. 
+PF03104 DNA_pol_B_exo;<br>DNA polymerase family B, exonuclease domain. This domain has 3' to 5' exonuclease activity and adopts a ribonuclease H type fold.. 
+PF04081 DNA polymerase delta, subunit 4 <br>Pfam-B_25322 (release 7.3);. 
+PF00772 DnaB-like helicase N terminal domain<br>Pfam-B_1000 (release 2.1). The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity  .. 
+PF03796 DnaB-like helicase C terminal domain<br>Pfam-B_1000 (release 2.1). The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.. 
+PF00226 DnaJ domain<br>DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction.  DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature  .. 
+PF03351 DOMON domain<br>Aravind L, Coggill P. The DOMON (named after dopamine beta-monooxygenase N-terminal) domain is 110-125 residues long. It is predicted to form an all beta fold with up to 11 strands and is secreted to the extracellular compartment. The beta-strand folding produces a hydrophobic pocket which appears to bind soluble haem. This is consistent with the predominant architectures where the protein is associated with cytochromes or enzymatic domains whose activity involves redox or electron transfer reactions potentially as a direct participant in the electron transfer process. The DOMON domain superfamily, of which this is just one member, shows (1) multiple hydrophobic residues that contribute to the hydrophobic core of the strands of the beta-sandwich, and small residues found at the boundaries of strands and loops, (2) a strongly conserved charged residue (usually arginine/lysine) at the end of strand 9, which possibly stabilises the loop between 9 and 10, and (3) a polar residue (usually histidine, lysine or arginine), that interacts or coordinates with ligands  . The suggested superfamily includes both haem- and sugar-binding members: the haem-binding families being the ethyl-Benzoate dehydrogenase family EB_dh, Pfam:PF09459, the cellobiose dehydrogenase family CBDH and this family, and the sugar-binding families being the xylanases, CBM_4_9, Pfam:PF02018. The common feature of the superfamily is the 11-beta-strand structure, although the first and eleventh strands are not well conserved either within families or between families.. 
+PF04124 Dor1-like family <br>Pfam-B_12640 (release 7.3);. Dor1 is involved in vesicle targeting to the yeast Golgi  apparatus and complexes with a number of other trafficking proteins, which include Sec34 and Sec35  .. 
+PF04173 TQO small subunit DoxD<br>Swiss:P97207 is a subunit of the terminal quinol oxidase present in the plasma  membrane of Acidianus ambivalens, with calculated molecular mass of 20.4 kDa  . Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation.  A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Swiss:Q8AAF0.. 
+PF00930 DPPIV_N_term; <br>Dipeptidyl peptidase IV (DPP IV) N-terminal region. Pfam-B_1017 (release 3.0). This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.. 
+PF05186 Dpy-30 motif<br>Pfam-B_13490 (release 7.7). 
+PF01414 Delta serrate ligand<br>Ponting CP, Schultz J, Bork P. 
+PF01666 DX module<br>This domain has no known function. It is found in several C. elegans proteins. The domain contains 6 conserved cysteines that probably form three disulphide bridges.. 
+PF00782 Dual specificity phosphatase, catalytic domain<br>Alignment kindly provided by SMART. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region  .. 
+PF00035 Double-stranded RNA binding motif<br>Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.. 
+PF01951 DUF101; <br>Archease protein family (MTH1598/TM1083). This archease family of proteins  , has two SHS2 domains  , with one inserted into another. It is predicted to be an enzyme  . It is predicted to act as a chaperone in DNA/RNA metabolism  . . 
+PF02575 DUF149;<br>YbaB/EbfC DNA-binding family. This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure [1-3]. The conformation of the DNA is changed when bound to these proteins  . In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage  .. 
+PF02580 DUF154;<br>D-Tyr-tRNA(Tyr) deacylase. This family comprises of several D-Tyr-tRNA(Tyr) deacylase proteins. Cell growth inhibition by several d-amino acids can be explained by an in vivo  production of d-aminoacyl-tRNA molecules. Escherichia coli and yeast cells express an enzyme, d-Tyr-tRNA(Tyr) deacylase, capable of recycling such d-aminoacyl-tRNA molecules into free tRNA and d-amino acid. Accordingly, upon inactivation of the genes of the above deacylases, the toxicity of d-amino acids increases. Orthologues of the deacylase are found in many cells  .. 
+PF02583 DUF156;<br>Metal-sensitive transcriptional repressor. This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [1-5].. 
+PF02588 Uncharacterized BCR, YitT family COG1284<br>This is probably a bacterial ABC transporter permease (personal obs:Yeats C).. 
+PF02639 Uncharacterized BCR, YaiI/YqxD family COG1671<br>
+PF02641 Uncharacterized ACR, COG1993<br>
+PF02958 DUF227;<br>Pfam-B_2081 (release 6.4). This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates  .. 
+PF02995 Protein of unknown function (DUF229)<br>Pfam-B_1566 (release 6.4). Members of this family are uncharacterised.  They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.. 
+PF01697 DUF23;<br>Glycosyltransferase family 92. Pfam-B_1694 (release 4.1). Members of this family act as galactosyltransferases, belonging to glycosyltransferase family 92 [1,2]. The aligned region contains several conserved cysteine residues and several charged residues that may be catalytic residues. This is supported by the inclusion of this family in the GT-A glycosyl transferase superfamily.. 
+PF02996 DUF232;<br>Pfam-B_1664 (release 6.4). This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT  .. 
+PF03080 DUF239; Glucoamylase;<br>Domain of unknown function (DUF239). Pfam-B_913 (release 6.4). This is a family of plant and bacterial proteins, a small number of which are putative carboxy-terminal peptidases (see for example Swiss:Q9XIN9).. 
+PF03087 Arabidopsis protein of unknown function<br>Pfam-B_1563 (release 6.5). This family represents a number of Arabidopsis proteins. Their functions are unknown.. 
+PF03103 Domain of unknown function (DUF243)<br>Pfam-B_1157 (release 6.5). This family of uncharacterised proteins is only found in fly proteins. It is found associated with YLP motifs Pfam:PF02757 in some proteins.. 
+PF03140 Plant protein of unknown function<br>Pfam-B_1292 (release 6.5). The function of the plant proteins constituting this family is unknown.. 
+PF03141 DUF248;<br>Putative S-adenosyl-L-methionine-dependent methyltransferase. Mifsud W, Moxon SJ, Eberhardt R. Pfam-B_1462 (release 6.5). This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [1,2].. 
+PF03164 DUF254; <br>Trafficking protein Mon1. Members of this family have been called SAND proteins   although these proteins do not contain a SAND domain.  In Saccharomyces cerevisiae a protein complex of Mon1 and Ccz1 functions with the small GTPase Ypt7 to mediate vesicle trafficking to the vacuole  . The Mon1/Ccz1 complex is conserved in eukaryotic evolution and members of this family (previously known as DUF254) are distant homologues to domains of known structure that assemble into cargo vesicle adapter (AP) complexes  .   describes orthologues in Fugu rubripes.. 
+PF03194 DUF259; <br>Pfam-B_2902 (release 6.5). This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein   with a role in splice site recognition  . The family also contains human and mouse LUC7 like (LUC7L) proteins   and human cisplatin resistance-associated overexpressed protein (CROP)  .. 
+PF01657 DUF26;<br>Salt stress response/antifungal. Pfam-B_980 (release 4.1). This domain is often found in association with the kinase domains Pfam:PF00069 or Pfam:PF07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges  . It has a role in salt stress response   and has antifungal activity  .. 
+PF03195 Protein of unknown function DUF260<br>Pfam-B_2998 (release 6.5). 
+PF03268 Caenorhabditis protein of unknown function, DUF267<br>Pfam-B_4201 (release 6.5). 
+PF03269 Caenorhabditis protein of unknown function, DUF268<br>Pfam-B_4252 (release 6.5). 
+PF03312 Protein of unknown function (DUF272)<br>Mifsud W, Pollington J. Pfam-B_3609 (release 6.5). This family of proteins is restricted to C.elegans and has no known function. The protein contains a ubiquitin fold. The GO annotation for the protein indicates that it has a function in nematode larval development.. 
+PF03409 DUF274; Glycoprotein_Ce;<br>Transmembrane glycoprotein. Pfam-B_4416 (release 6.6). This family of proteins has some GO annotations for positive regulation of growth rate and nematode larval development. This is probably a family of membrane glycoproteins  .. 
+PF03357 DUF279; SNF7; ESCRT-III; <br>Mifsud W, Moxon SJ, Mistry J, Wood V. Pfam-B_1641 (release 6.6). This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localisation, requires the formation of multivesicular bodies (MVBs).  These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins  . A few archaeal sequences are also present within this family.. 
+PF03380 Caenorhabditis protein of unknown function, DUF282<br>Pfam-B_2840 (release 6.6). 
+PF03368 DUF283; dsRNA_bind;<br>Dicer dimerisation domain. 
+PF03382 Mycoplasma protein of unknown function, DUF285<br>Pfam-B_2864 (release 6.6). This region appears distantly related to leucine rich repeats.. 
+PF01060 Worm_family_2; <br>Transthyretin-like family. This family called family 2 in  , has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones.\.      The specific function of this protein is unknown.. 
+PF03478 Protein of unknown function (DUF295)<br>Pfam-B_790 (release 7.0). This family of proteins are found in plants.  The function of the proteins is unknown.. 
+PF03556 DUF298;<br>Pfam-B_3021 (release 7.0). This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation [1-3]. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices [1,2].. 
+PF03619 DUF300;<br>Organic solute transporter Ostalpha. Pfam-B_3382 (release 7.0). This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters  . In plants they may transport brassinosteroid-like compounds and act as regulators of cell death  .. 
+PF03703 DUF304;<br>Domain found in uncharacterised family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure  .. 
+PF03713 Domain of unknown function (DUF305)<br>Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1.  This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important.  This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.. 
+PF03754 Domain of unknown function (DUF313) <br>Pfam-B_2540 (release 7.0). Family of proteins from Arabidopsis thaliana with uncharacterised function.. 
+PF03761 Domain of unknown function (DUF316) <br>Pfam-B_2972 (release 7.0). This family of proteins with unknown function are from Caenorhabditis elegans. The protein has GO references indicating the protein is a positive regulator of growth rate and is also involved in nematode larval development.. 
+PF03777 Small secreted domain (DUF320)  <br>Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.. 
+PF03860 Domain of Unknown Function (DUF326) <br>This family is a small cysteine-rich repeat. The cysteines mostly follow a C-X(2)-C-X(3)-C-X(2)-C-X(3) pattern,  though they often appear at other positions in the repeat as well.. 
+PF03935 DUF338; <br>Beta-glucan synthesis-associated protein (SKN1). This family consists of the beta-glucan synthesis-associated proteins KRE6 and SKN1. Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-glucan, and chitin. It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1. This is followed by maturation steps at the cell surface and by coupling to other cell wall macromolecules  . . 
+PF03990 Domain of unknown function (DUF348)     <br>This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593 (Swiss:P25357).  This protein is involved in sporulation part of the  SET3C complex, which is required to repress early/middle sporulation genes during meiosis ( ). The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction  with the Pfam:PF07501 domain, which is involved in various cell surface processes.. 
+PF03993 Domain of Unknown Function (DUF349)<br>This domain is found singly or as up to five tandem repeats in a small set of  bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.. 
+PF04008 DUF355; <br>Adenosine specific kinase. The structure of a member of this family from the hyperthermophilic archaeon Pyrobaculum aerophilum contains a modified histidine residue which is interpreted as stable phosphorylation  . In vitro binding studies confirmed that adenosine and AMP but not ADP or ATP bind to the protein  .. 
+PF04013 DUF358;<br>Putative SAM-dependent RNA methyltransferase. This family is likely to be an S-adenosyl-L-methionine (SAM)-dependent RNA methyltransferase  .. 
+PF04020 Membrane protein of unknown function<br>These proteins a predicted transmembrane proteins with probably four transmembrane spans. The function of these bacterial proteins is unknown. The sequences do not appear to contain any conserved polar residues that could form an active site.. 
+PF04037 Domain of unknown function (DUF382) <br>Pfam-B_10232 (release 7.3);. This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site  .. 
+PF04075 Domain of unknown function (DUF385) <br>TIGRFAMs (release 2.0);. Family of Mycobacterium tuberculosis proteins.. 
+PF04087 Domain of unknown function (DUF389) <br>TIGRFAMs (release 2.0);. Family of hypothetical bacterial proteins with  an undetermined function.. 
+PF04155 DUF398; <br>Pfam-B_3296 (release 7.3). This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides  .  . 
+PF04241 Protein of unknown function (DUF423)<br>This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.. 
+PF04255 Protein of unknown function (DUF433)<br>
+PF01862 DUF44;<br>Pyruvoyl-dependent arginine decarboxylase (PvlArgDC). Methanococcus jannaschii contains homologues of most genes required for spermidine polyamine biosynthesis. Yet genomes from neither this organism nor any other euryarchaeon have orthologues of the pyridoxal 5'-phosphate- dependent ornithine or arginine decarboxylase genes, required to produce putrescine. Instead,these organisms have a new class of arginine decarboxylase (PvlArgDC) formed by the self-cleavage of a proenzyme into a 5-kDa subunit and a 12-kDa subunit that contains a reactive pyruvoyl group. Although this extremely thermostable enzyme has no significant sequence similarity to previously characterised proteins, conserved active site residues are similar to those of the pyruvoyl-dependent histidine decarboxylase enzyme, and its subunits form a similar (alpha-beta)(3) complex. Homologues of PvlArgDC are found in several bacterial genomes, including those of Chlamydia spp., which have no agmatine ureohydrolase enzyme to convert agmatine (decarboxylated arginine) into putrescine. In these intracellular pathogens, PvlArgDC may function analogously to pyruvoyl-dependent histidine decarboxylase; the cells are proposed to import arginine and export agmatine, increasing the pH and affecting the host cell's metabolism. Phylogenetic analysis of Pvl- ArgDC proteins suggests that this gene has been recruited from the euryarchaeal polyamine biosynthetic pathway to function as a degradative enzyme in bacteria  .. 
+PF04332 Protein of unknown function (DUF475)<br>Predicted to be an integral membrane protein with multiple membrane spans.. 
+PF04720 Protein of unknown function (DUF506) <br>Pfam-B_4111 (release 7.5). Family of uncharacterised plant proteins.. 
+PF04784 Protein of unknown function, DUF547<br>Pfam-B_3926 (release 7.5). Family of uncharacterised proteins from C. elegans and A. thaliana. . 
+PF04484 Family of unknown function (DUF566) <br>Pfam-B_3992 (release 7.5). Family of related proteins that is plant specific.. 
+PF04526 Protein of unknown function (DUF568)<br>Pfam-B_4977 (release 7.5). Family of uncharacterised plant proteins.. 
+PF04502 Family of unknown function (DUF572) <br>Pfam-B_3967 (release 7.5). Family of eukaryotic proteins with undetermined function.. 
+PF04504 Protein of unknown function, DUF573<br>Pfam-B_2087 (release 7.5). 
+PF04535 Domain of unknown function (DUF588)<br>Pfam-B_1439 (release 7.5). This family of plant proteins contains a domain that may have a catalytic activity.  It has a conserved arginine and aspartate that could form an active site. These proteins are predicted to contain 3 or 4 transmembrane helices.. 
+PF01883 Domain of unknown function DUF59<br>This family has an alpha/beta topology, with 13 conserved hydrophobic residues at its core and a putative active site containing a highly conserved cysteine  . Members of this family are involved in a range of physiological functions. The family includes PaaJ (PhaH) Swiss:O84984 from Pseudomonas putida. PaaJ forms a complex with PaaG (PhaF) Swiss:O84982, PaaI (PhaG) Swiss:O84983 and PaaK (PhaI) Swiss:O84985, which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid  . It also includes PaaD Swiss:P76080 from Escherichia coli, a member of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation  . It is found near the N-terminus of the chloroplast scaffold protein HCF101 Swiss:Q8LD16, involved in the assembly of [4Fe-4S] clusters and their transfer to apoproteins  .. 
+PF04547 DUF590; <br>Calcium-activated chloride channel. Pfam-B_2735 (release 7.5). The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes  .. 
+PF04576 DUF593;<br>Mifsud W, Eberhardt R. Pfam-B_2802 (release 7.5). This domain binds to zein proteins, Pfam:PF01559  . Zein proteins are seed storage proteins.. 
+PF04642 Protein of unknown function, DUF601<br>Pfam-B_5475 (release 7.5). This family represents a conserved region found in several uncharacterised plant proteins.. 
+PF04641 DUF602;<br>Mifsud W, Pollington J. Pfam-B_5482 (release 7.5). It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site  . This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family  .. 
+PF04652 Vta1 like<br>Mifsud W, Mistry J, Wood V. Pfam-B_5537 (release 7.5). Vta1 (VPS20-associated protein 1) is a positive regulator of Vps4.  Vps4 is an ATPase that is required in the multivesicular body (MVB) sorting pathway to dissociate the endosomal sorting complex required for transport (ESCRT).  Vta1 promotes correct assembly of Vps4 and stimulates its ATPase activity through its conserved Vta1/SBP1/LIP5 region  .. 
+PF04678 Protein of unknown function, DUF607<br>Pfam-B_5620 (release 7.5). This family represents a conserved region found in several uncharacterised eukaryotic proteins.. 
+PF04685 Protein of unknown function, DUF608<br>Pfam-B_5657 (release 7.5). This family represents a conserved region with a pankaryotic distribution in a number of uncharacterised proteins.. 
+PF04727 DUF609; <br>Pfam-B_3095 (release 7.5). This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells  . ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.. 
+PF04747 Protein of unknown function, DUF612<br>Pfam-B_3614 (release 7.5). This family includes several uncharacterised proteins from Caenorhabditis elegans.. 
+PF04749 DUF614; <br>Pfam-B_3635 (release 7.5). This family includes Swiss:Q9NZF1, the Placenta-specific gene 8 protein.. 
+PF04759 Protein of unknown function, DUF617<br>Pfam-B_3842 (release 7.5). This family represents a conserved region in a number of uncharacterised plant proteins.. 
+PF04818 DUF618;<br>RNA polymerase II-binding domain.. Mifsud W, Eberhardt R. Pfam-B_3687 (release 7.6). This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II [1,2].. 
+PF04789 Protein of unknown function (DUF621)<br>Pfam-B_6219 (release 7.5). Family of uncharacterised proteins. Some (such as Swiss:O01625) are annotated as having possible G-protein-coupled receptor-like activity.. 
+PF04802 DUF625; SMK-1_Ce; <br>Component of IIS longevity pathway SMK-1. Pfam-B_6319 (release 7.5). SMK-1 is a component of the IIs longevity pathway which regulates aging in C.elegans. Specifically, SMK-1 influences DAF-16-dependant regulation of the aging process by regulating the transcriptional specificity of DAF-16 activity  . SMK-1 plays a role in longevity by modulating the transcriptional specificity of DAF-16  .. 
+PF04783 Protein of unknown function (DUF630)<br>Pfam-B_2481 (release 7.6). This region is sometimes found at the N-terminus of putative plant bZIP proteins.  Its function is not known. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF01683 EB module<br>This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains Pfam:PF00014.. 
+PF04782 Protein of unknown function (DUF632)<br>Pfam-B_2481 (release 7.6). This plant protein may be a leucine zipper, but there is no experimental evidence for this.. 
+PF04826 DUF634;<br>Pfam-B_2700 (release 7.6). This domain contains armadillo-like repeats  . Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis  , control of cellular ageing and survival  , regulation of circadian rhythm   and lysosomal sorting of G protein-coupled receptors  .. 
+PF04859 Plant protein of unknown function (DUF641)<br>Pfam-B_6069 (release 7.6). Plant protein of unknown function.. 
+PF04884 Vitamin B6 photo-protection and homoeostasis<br>Mifsud W, Eberhardt R. Pfam-B_6523 (release 7.6). In plants, this domain plays a role in auxin-transport, plant growth and development [1,2] and appears to be expressed by all cells in the plant as well as in plastids. The family has been shown to play a role in vitamin B6 photo-protection and homoeostasis in plants  .. 
+PF04900 DUF652; <br>Mifsud W, Wood V, Mistry J. Pfam-B_6634 (release 7.6). Fcf1 is a nucleolar protein involved in pre-rRNA processing  . Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits  .. 
+PF04949 DUF662;<br>Transcriptional activator. Pfam-B_6952 (release 7.6). This family of proteins may act as a transcriptional activator. It plays a role in stress response in plants  .. 
+PF04950 Protein of unknown function (DUF663)<br>Pfam-B_5147 (release 7.6). This family contains several uncharacterised eukaryotic proteins.. 
+PF05057 Putative serine esterase (DUF676)<br>Pfam-B_5941 (release 7.7). This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.. 
+PF05097 Protein of unknown function (DUF688)<br>Pfam-B_6331 (release 7.7). This family contains several uncharacterised proteins found in Arabidopsis thaliana.. 
+PF05108 Protein of unknown function (DUF690)<br>Pfam-B_6322 (release 7.7). This family contains several uncharacterised bacterial membrane proteins.. 
+PF05127 DUF699;<br>Pfam-B_884 (release 7.7). This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain  . It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases  .. 
+PF05129 DUF701; <br>Transcription elongation factor Elf1 like. Pfam-B_8884 (release 7.7). This family of short proteins contains a putative zinc binding domain with four conserved cysteines.  Swiss:P36053 has been identified as a transcription elongation factor in Saccharomyces cerevisiae  .. 
+PF05197 DUF714; <br>Pfam-B_9855 (release 7.7). TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalent cation-selective channel  .. 
+PF01031 dynamin_2; <br>Dynamin central region. Pfam-B_220 (release 3.0). This region lies between the GTPase domain, see Pfam:PF00350, and the pleckstrin  homology (PH) domain, see Pfam:PF00169.. 
+PF03028 Dynein heavy chain and region D6 of dynein motor<br>Pfam-B_928 (release 6.4). This family represents the C-terminal region of dynein heavy chain.  The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains  . The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained  .. 
+PF04261 Dyp_perox_fam; <br>Dyp-type peroxidase family . TIGRFAMs (release 2.0);. This family of dye-decolourising peroxidases lack a typical heme-binding region.. 
+PF02221 ML domain<br>ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 (Swiss:Q15668) causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.. 
+PF03271 EB1-like C-terminal motif<br>Pfam-B_1529 (release 6.5). This motif is found at the C-terminus of proteins that are related to the EB1 protein.  The EB1 proteins contain an N-terminal CH domain Pfam:PF00307. The human EB1 protein was originally discovered as a protein interacting with the C-terminus of the APC protein. This interaction is often disrupted in colon cancer, due to deletions affecting the  APC C-terminus. Several EB1 orthologues are also included in this family.  The interaction between EB1 and APC has been shown to have a potent synergistic effect on microtubule polymerisation. Neither of EB1 or APC alone has this effect. It is thought that EB1 targets APC to the + ends of microtubules, where APC promotes microtubule polymerisation. This process is regulated by APC phosphorylation by Cdc2, which disrupts APC-EB1 binding. Human EB1 protein can functionally substitute for the yeast EB1 homologue Mal3. In addition, Mal3 can substitute for human EB1 in promoting microtubule polymerisation with APC.. 
+PF05009 EBNA-3;<br>Epstein-Barr virus nuclear antigen 3 (EBNA-3). Pfam-B_4674 (release 7.6). This family contains EBNA-3A, -3B, and -3C which are latent infection nuclear proteins important for Epstein-Barr virus (EBV)-induced B-cell immortalisation and the immune response to EBV infection  .. 
+PF00679 Elongation factor G C-terminus<br>Pfam-B_40 (release 2.1). This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a  ferredoxin-like fold.. 
+PF03764 Elongation factor G, domain IV<br>Pfam-B_40 (release 2.1). This domain is found in elongation factor G, elongation  factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.. 
+PF00036 efhand; EF_hand_1;<br>The EF-hands can be divided into two classes: signaling proteins and buffering/transport proteins.  The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site.  The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.. 
+PF04189 eIF3_gamma; <br>Pfam-B_8933 (release 7.3);. eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3 [1,2]. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA  .. 
+PF03610 PTS system fructose IIA component<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01448 ELM2 domain<br>The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex  . The domain is usually found to the N terminus of a myb-like DNA binding domain Pfam:PF00249. ELM2 is also found associated with an ARID DNA binding domain Pfam:PF01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.. 
+PF02990 Endomembrane protein 70<br>Pfam-B_1312 (release 6.4). 
+PF01223 Endonuclease; <br>DNA/RNA non-specific endonuclease. 
+PF00812 Ephrin<br>Pfam-B_1390 (release 2.1). 
+PF05139 Erythromycin esterase<br>This family includes erythromycin esterase enzymes [1,2] that confer resistance to the erythromycin antibiotic.. 
+PF04800 ETC_CI_21; <br>ETC complex I subunit conserved region. Pfam-B_6275 (release 7.5). Family of pankaryotic NADH-ubiquinone oxidoreductase subunits (EC:1.6.5.3) (EC:1.6.99.3) from complex I of the electron transport chain initially identified in Neurospora crassa as a 21 kDa protein  .. 
+PF04716 ETC_CI_29_9;<br>ETC complex I subunit conserved region. Pfam-B_4159 (release 7.5). Family of eukaryotic NADH-ubiquinone oxidoreductase subunits (EC:1.6.5.3) (EC:1.6.99.3) from complex I of the electron transport chain initially identified in Neurospora crassa as a 29.9 kDa protein. The conserved region is found at the N-terminus of the member proteins  .. 
+PF04621 PEA3 subfamily ETS-domain transcription factor N terminal domain<br>The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding  . Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades.  The N terminal region contains conserved MAP kinase phosphorylation sites  .. 
+PF04777 Erv1 / Alr family<br>Pfam-B_5005 (release 7.6). Biogenesis of Fe/S clusters involves a number of essential mitochondrial  proteins. Erv1p of Saccharomyces cerevisiae mitochondria is  required for the maturation of Fe/S proteins in the cytosol. The ALR  (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the  mitochondrial intermembrane an d it thought to operate downstream of  the mitochondrial ABC transporter  .  . 
+PF03372 Endonuclease/Exonuclease/phosphatase family<br>This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling  . This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.. 
+PF02609 Exonuclease VII small subunit<br>This family consist of exonuclease VII, small subunit EC:3.1.11.6 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones  .. 
+PF00929 Exonuclease; Exonuc_X-T;<br>Pfam-B_1153 (release 3.0). This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.; . 
+PF03016 Exostosin family<br>Pfam-B_2031 (release 6.4). The EXT family is a family of tumour suppressor genes.  Mutations of EXT1 Swiss:Q16394 on 8q24.1, EXT2 Swiss:Q93063 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia.  EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities  . The nature of the defect in heparan sulphate biosynthesis in HME is unclear.. 
+PF03124 EXS family<br>Pfam-B_605 (release 6.5). We have named this region the EXS family after (ERD1, XPR1, and SYG1). This family includes C-terminus portions from the SYG1 G-protein associated signal transduction protein from Saccharomyces cerevisiae, and sequences that are thought to be murine leukaemia virus (MLV)  receptors (XPR1). N-terminus portions from these proteins are aligned in the SPX  Pfam:PF03105 family. The previously noted similarity between SYG1 and MLV receptors over their whole sequences   is thus borne out in Pfam:PF03105 and this family. While the N-termini aligned in Pfam:PF03105 are thought to be involved in signal transduction, the role of the C-terminus sequences aligned in this family is not known. This region of similarity contains several predicted transmembrane helices. This family also includes the ERD1 (ERD: ER retention  defective) yeast proteins Swiss:P16151.  ERD1 proteins are involved in the localisation of endogenous endoplasmic reticulum (ER) proteins. erd1 null mutants secrete such proteins even though they possess the C-terminal HDEL ER lumen localisation label sequence. In addition, null mutants also exhibit defects in the Golgi-dependent processing of several glycoproteins, which led to the suggestion that the sorting of luminal ER proteins actually occurs in the Golgi, with subsequent return of these proteins to the ER via  `salvage' vesicles  .. 
+PF04554 Extensin-like region<br>Pfam-B_1707 (release 7.5). 
+PF00646 F-box domain<br>This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07723) and the WD repeat (Pfam:PF00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression  .. 
+PF00754 F5/8 type C domain<br>Pfam-B_478 (release 2.1). This domain is also known as the discoidin (DS) domain family  .. 
+PF00487 Fatty acid desaturase<br>
+PF02913 FAD linked oxidases, C-terminal domain<br>This domain has a ferredoxin-like fold.. 
+PF01565 FAD binding domain <br>Pfam-B_352 (release 4.0). This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110  . The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyses the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyses the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158.  This enzyme is involved in the biosynthesis of peptidoglycan  .. 
+PF00970 Cyt_reductase; <br>Oxidoreductase FAD-binding domain. Pfam-B_143 (release 3.0). 
+PF03441 FAD binding domain of DNA photolyase<br>
+PF03101 FAR1 DNA-binding domain<br>Pfam-B_2535 (release 6.4). This domain contains a WRKY like fold and is therefore most likely a zinc binding DNA-binding domain.. 
+PF04300 F-box associated region<br>Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Swiss:Q9UK22 is involved in binding to N-glycosylated proteins.. 
+PF00611 Fes/CIP4, and EFC/F-BAR homology domain<br>Ponting C, Schultz J, Bork P. Alignment extended from  . Highly alpha-helical.  The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins  . These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localise to actin-rich structures  .. 
+PF00111 fer2; <br>2Fe-2S iron-sulfur cluster binding domain. 
+PF01799 fer2_2; <br>[2Fe-2S] binding domain. 
+PF04324 fer2_BFD; <br>BFD-like [2Fe-2S] binding domain. The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD, Swiss:P13655).  The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria  .  This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (Pfam:PF01077), Nitrite/Sulfite reductase ferredoxin-like half domain (Pfam:PF03460) and Pyridine nucleotide-disulphide oxidoreductase (Pfam:PF00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (Pfam:PF01592) and NifU-like domain (Pfam:PF01106).. 
+PF00037 fer4; <br>4Fe-4S binding domain. Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF00210 ferritin; <br>Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.. 
+PF01839 FG-GAP repeat<br>This family contains the extracellular repeat that is found in up to seven copies in alpha integrins.  This repeat has been predicted to fold into a beta propeller structure  . The repeat is called the FG-GAP repeat after two conserved motifs in the repeat  .  The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding  . A putative Ca2+ binding motif is found in some of the repeats.. 
+PF02181 Formin Homology 2 Domain<br>Alignment kindly provided by SMART. 
+PF02661 Fic/DOC family<br>This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing).  The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism  .  This family contains a central conserved motif HPFXXGNG in most members.  The exact molecular function of these proteins is uncertain.  P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation  .  A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1  . In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family  . Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc  .This domain forms complexes with Phd antitoxins containing Pfam:PF02604.. 
+PF00254 FKBP; <br>FKBP-type peptidyl-prolyl cis-trans isomerase. 
+PF01003 Flavivirus capsid protein C<br>Pfam-B_156 (release 3.0)  . Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E.  Multiple copies of the C protein  form the nucleocapsid, which contains the ssRNA molecule.. 
+PF02832 Flavivirus glycoprotein, immunoglobulin-like domain<br>Pfam-B_146 (release 3.0). 
+PF00869 Flavivirus glycoprotein, central and dimerisation domains<br>Pfam-B_146 (release 3.0). 
+PF00949 Flavi_helicase; <br>Peptidase S7, Flavivirus NS3 serine protease . Pfam-B_199 (release 3.0). The viral genome is a positive strand RNA that encodes a single  polyprotein precursor. Processing of the polyprotein precursor into mature proteins is carried out by the host signal peptidase and by NS3 serine  protease, which requires NS2B (Pfam:PF01002) as a cofactor  . . 
+PF01004 Flavivirus envelope glycoprotein M<br>Pfam-B_156 (release 3.0)  . Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.. 
+PF00948 Flavivirus non-structural Protein NS1 <br>Pfam-B_157 (release 3.0). The NS1 protein is well conserved amongst the flaviviruses. It contains 12 cysteines, and undergoes glycosylation in a similar manner to other NS proteins.  Mutational analysis has strongly  implied a role for NS1 in the early stages of RNA replication.. 
+PF01005 Flavivirus non-structural protein NS2A<br>Pfam-B_156 (release 3.0). NS2A is a hydrophobic protein about 25 kDa is size.  NS2A is  cleaved from NS1 by a membrane bound host protease  .  NS2A has been found to associate with the dsRNA within the vesicle packages.  It has also been found that NS2A associates with the  known replicase components and so NS2A has been postulated to be part of this replicase complex  . . 
+PF01002 Flavivirus non-structural protein NS2B<br>Pfam-B_156 (release 3.0). Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. All, but two, are cleaved by the NS2B-NS3 protease complex.. 
+PF01613 Flavin reductase like domain<br>Pfam-B_710 (release 4.1). This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin  . SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalysed by SnaA, SnaB heterodimer  .  This flavin reductase region characterised by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain  .. 
+PF00258 flavodoxin; <br>
+PF04500 FLYWCH zinc finger domain<br>Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in  .. 
+PF03358 NADPH-dependent FMN reductase<br>Pfam-B_2010 (release 6.6). 
+PF02434 Fringe-like<br>Pfam-B_1900 (release 5.4). The drosophila protein fringe (FNG) is a  glucosaminyltransferase that controls the response of the Notch receptor to specific ligands  . FNG is localised to the Golgi apparatus   (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homologue, lunatic fringe, has been implicated in a variety of functions.. 
+PF01534 Frizzled/Smoothened family membrane region<br>Pfam-B_949 (release 4.0). This family contains the membrane spanning region of frizzled and smoothened receptors.  This membrane region is predicted to contain seven transmembrane alpha helices.  Proteins related to Drosophila frizzled (Swiss:P18537) are receptors for Wnt (mediating the beta-catenin signalling pathway)  , but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding  .  The smoothened receptor mediates hedgehog signalling  .. 
+PF01827 DUF38; <br>Pfam-B_67 (release 4.2). This presumed domain is likely to be a protein-protein interaction module  . It is found in many proteins from C. elegans. The domain is found associated with the F-box Pfam:PF00646. This domain is named FTH after FOG-2 homology domain  .. 
+PF01913 Formylmethanofuran-tetrahydromethanopterin formyltransferase<br>This enzyme EC:2.3.1.101 is involved in archaebacteria in the formation of methane from carbon dioxide. N-terminal distal lobe of alpha+beta ferredoxin-like fold. SCOP reports fold duplication with C-terminal proximal lobe.. 
+PF02741 FTR, proximal lobe<br>The FTR (Formylmethanofuran--tetrahydromethanopterin formyltransferase) enzyme EC:2.3.1.101 is involved in archaebacteria in the formation of methane from carbon dioxide. C-terminal proximal lobe of alpha+beta ferredoxin-like fold. SCOP reports fold duplication with N-terminal distal lobe.. 
+PF01728 FtsJ-like methyltransferase<br>Pfam-B_1791 (release 4.1). This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping  .. 
+PF02687 DUF214; <br>FtsX-like permease family. This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.. 
+PF04082 Fungal specific transcription factor domain <br>Pfam-B_306 (release 7.3);. 
+PF01363 FYVE zinc finger<br>Pfam-B_655 (release 3.0). The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions  . The FYVE finger has eight potential zinc coordinating cysteine positions.  Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.  We have included members which do not conserve these histidine residues but are clearly related.. 
+PF01392 Fz domain<br>Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4].  The domain contains 10 conserved cysteines.. 
+PF01585 G7; <br>Pfam-B_585 (release 4.1). This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains.  This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.. 
+PF01019 Gamma-glutamyltranspeptidase<br>Pfam-B_878 (release 3.0). 
+PF04114 Gaa1-like, GPI transamidase component <br>Pfam-B_12685 (release 7.3);. GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex.  Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase  that adds glycosylphosphatidylinositols (GPIs) to newly  synthesised proteins. . 
+PF01590 GAF domain<br>This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.. 
+PF01140 gag_MA;<br>Matrix protein (MA), p15. Pfam-B_229 (release 3.0). The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity  .. 
+PF01141 gag_p12; <br>Gag polyprotein, inner coat protein p12. Pfam-B_821 (release 3.0). The retroviral p12 is a virion structural protein. p12 is proline rich.  The function carried out by p12 in assembly and replication is unknown.  p12 is associated with pathogenicity of the virus  .. 
+PF02140 Galactose binding lectin domain<br>
+PF03127 GAT domain<br>The GAT domain is responsible for binding of GGA proteins to several members of the ARF family including ARF1   and ARF3. The GAT domain stabilises membrane bound ARF1 in its GTP bound state, by interfering with GAP proteins  .. 
+PF00320 GATA zinc finger<br>This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors.  However there are several proteins which only contains a single copy of the domain.. 
+PF00117 Glutamine amidotransferase class-I<br>
+PF02934 PET112_N; <br>GatB/GatE catalytic domain. This domain is found in the GatB and GatE proteins  .. 
+PF02637 DUF186;<br>This domain is found in GatB. It is about 140 amino acid residues long.  This domain is found at the C terminus of GatB Swiss:O30509 which transamidates Glu-tRNA to Gln-tRNA.. 
+PF03615 GCM motif protein<br>
+PF03074 Glutamate-cysteine ligase<br>Pfam-B_541 (release 6.4). This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS).\.       This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).. 
+PF03009 Glycerophosphoryl diester phosphodiesterase family<br>Pfam-B_4008 (release 6.4). E. coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted  . This family appears to have weak but not significant matches to mammalian phospholipase C Pfam:PF00388, which suggests that this family may adopt a TIM barrel fold.. 
+PF00626 Gelsolin repeat<br>
+PF01408 Oxidoreductase family, NAD-binding Rossmann fold<br>Pfam-B_342 (release 3.0). This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.. 
+PF02894 Oxidoreductase family, C-terminal alpha/beta domain<br>Pfam-B_342 (release 3.0). This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.. 
+PF00990 DUF9; <br>Pfam-B_112 (release 3.0). This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain   and has diguanylate cyclase activity  . This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate.. 
+PF03321 GH3 auxin-responsive promoter<br>Pfam-B_3652 (release 6.5). 
+PF00288 GHMP_kinases; <br>GHMP kinases N terminal domain. This family includes homoserine kinases, galactokinases and mevalonate kinases.. 
+PF00594 gla; <br>Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain. This  domain is  responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).. 
+PF00208 E_L_F_V_dh; GLFV_dehydrog; <br>Glutamate/Leucine/Phenylalanine/Valine dehydrogenase. 
+PF00042 globin; <br>Structure_superposition. 
+PF04898 Glutamate synthase central domain<br>Pfam-B_455 (release 7.6). The central domain of glutamate synthase connects the amino terminal amidotransferase domain with the FMN-binding domain and has an alpha / beta overall topology  .  This domain appears to be a rudimentary form of the FMN-binding TIM barrel according to SCOP.. 
+PF04960 Glutaminase<br>This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.. 
+PF04488 Glycosyltransferase sugar-binding region containing DXD motif   <br>The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other  sugars, phosphates and proteins.  DXD-containing glycosyltransferases all  use nucleoside diphosphate sugars as donors and require divalent cations,  usually manganese.  The DXD motif is expected to play a carbohydrate  binding role in sugar-nucleoside diphosphate and manganese dependent  glycosyltransferases  .. 
+PF00722 glycosyl_hydro9; <br>Glycosyl hydrolases family 16. Pfam-B_759 (release 2.1). 
+PF00704 glycosyl_hydro8; <br>Glycosyl hydrolases family 18. Pfam-B_574 (release 2.1). 
+PF02055 O-Glycosyl hydrolase family 30<br>
+PF01055 Glycosyl_hydr15; <br>Glycosyl hydrolases family 31 . Pfam-B_369 (release 3.0). Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.. 
+PF01532 Glycosyl hydrolase family 47<br>Pfam-B_958 (release 4.0). Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).. 
+PF03200 Mannosyl oligosaccharide glucosidase<br>Pfam-B_2589 (release 6.5). This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyse the specific  cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway.. 
+PF03648 Glyco_hydro_67; <br>Glycosyl hydrolase family 67 N-terminus. Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the N-terminal region of alpha-glucuronidase. The N-terminal domain forms a two-layer sandwich, each layer being formed by a beta sheet of five strands. A further two helices  form part of the interface with the central, catalytic, module (Pfam:PF07488)  . . 
+PF03663 Glycosyl hydrolase family 76 <br>Family of alpha-1,6-mannanases.. 
+PF03644 Glycosyl hydrolase family 85 <br>Family of endo-beta-N-acetylglucosaminidases.  These enzymes work on a broad spectrum of substrates.. 
+PF04101 Glycosyltransferase family 28 C-terminal domain<br>Pfam-B_1105 (release 6.4). The glycosyltransferase family 28 includes  monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.. 
+PF00852 Fucosyl_transf; <br>Glycosyltransferase family 10 (fucosyltransferase). Pfam-B_1677 (release 2.1). This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage  . This family is know as glycosyltransferase family 10  .. 
+PF00982 TrehaloseP_syn;<br>Glycosyltransferase family 20. Pfam-B_1035 (release 3.0). Members of this family belong to glycosyl transferase family 20  . OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex,  .. 
+PF01755 LPS_glycoyl_T; <br>Glycosyltransferase family 25 (LPS biosynthesis protein). Pfam-B_1857 (release 4.1). Members of this family belong to Glycosyltransferase family 25   This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyse the transfer of various sugars onto the growing LPS chain during its biosynthesis.. 
+PF00777 Sialyltransf; <br>Glycosyltransferase family 29 (sialyltransferase). Pfam-B_1020 (release 2.1). Members of this family belong to glycosyltransferase family 29  .. 
+PF03360 Glyco_tranf_43;<br>Glycosyltransferase family 43. Pfam-B_1447 (release 6.6). 
+PF01501 Glycosyl transferase family 8<br>Pfam-B_730 (release 4.0) & Pfam-B_5903 (Release 7.5). This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase Swiss:P27128, lipopolysaccharide glucosyltransferase 1 Swiss:P27129, and glycogenin glucosyltransferase Swiss:P46976.. 
+PF00535 glycosyl_transf_2;<br>Glycosyl transferase family 2. MRC-LMB Genome group. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.. 
+PF00953 Glycosyl transferase family 4<br>Pfam-B_534 (release 3.0). 
+PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily<br>Pfam-B_1207 (release 3.0) & Pfam-B_5495 (Release 8.0). 
+PF04464 glyphos_transf; <br>CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase . Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerisation of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate  units from CDP-glycerol to the linkage unit lipid  .. 
+PF00958 GMP synthase C terminal domain<br>Pfam-B_1137 (release 3.0). GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. This family is the C-terminal domain specific to the GMP synthases Swiss:P49915 EC:6.3.5.2. In prokaryotes this domain mediates dimerisation. Eukaryotic GMP synthases are monomers. This domain in eukaryotes includes several large insertions that may form globular domains.. 
+PF01825 Latrophilin/CL-1-like GPS domain<br>Domain present in latrophilin/CL-1, sea urchin REJ and polycystin.. 
+PF02893 GRAM domain<br>Alignment kindly provided by SMART. The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.. 
+PF03514 GRAS domain family<br>Pfam-B_393 (release 7.0). Proteins in the GRAS (GAI, RGA, SCR) family are known as  major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development  .  Mutation of the SCARECROW (SCR) gene results in a radial  pattern defect, loss of a ground tissue layer, in the root.  The PAT1 protein is involved in phytochrome A signal  transduction  . A sequence, structure and evolutionary  analysis showed that the GRAS family emerged in bacteria  and belongs to the Rossmann-fold, AdoMET (SAM)-dependent  methyltransferase superfamily  . All bacterial, and a subset  of plant GRAS proteins, are predicted to be active and function  as small-molecule methylases. Several plant GRAS proteins  lack one or more AdoMet (SAM)-binding residues while  preserving their substrate-binding residues. Although GRAS   proteins are implicated to function as transcriptional factors,  the above analysis suggests that they instead might either   modify or bind small molecules  .. 
+PF01465 GRIP domain<br>The GRIP (golgin-97, RanBP2alpha,Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. The GRIP domain contains a completely conserved tyrosine residue. At least some of these domains have been shown to bind to GTPase Arl1, see structures in [4,5].. 
+PF02946 GTF2I-like repeat<br>Pfam-B_101 (release 6.4). This region of sequence similarity is found up to six times in a variety of proteins including GTF2I.  It has been suggested that this may be a DNA binding domain [1,2].. 
+PF01018 GTP1/OBG<br>Pfam-B_875 (release 3.0). The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.. 
+PF00009 Elongation factor Tu GTP binding domain<br>This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.. 
+PF03144 Elongation factor Tu domain 2<br>Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA  . This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.. 
+PF03143 Elongation factor Tu C-terminal domain<br>Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA   and binding to EF-Ts Pfam:PF00889  .. 
+PF01493 DUF14; <br>Pfam-B_428 (release 4.0). This domain is found in glutamate synthase, tungsten formylmethanofuran dehydrogenase subunit c (FwdC) and molybdenum formylmethanofuran dehydrogenase subunit c (FmdC). A repeated G-XX-G-XXX-G motif is seen in the alignment.. 
+PF02756 GYR motif<br>The GYR motif is found in several drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues may suggest it could be a substrate for tyrosine kinases.. 
+PF03457 Helicase associated domain<br>This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices.  The function of this domain may be to bind nucleic acid.. 
+PF04408 Helicase associated domain (HA2)<br>This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.. 
+PF04774 Hyaluronan / mRNA binding family<br>Pfam-B_2044 (release 7.6). This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1.  HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo.  It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan  . PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability  . However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.. 
+PF02183 Homeobox associated leucine zipper<br>Alignment kindly provided by SMART & Pfam-B_1492 (Release 7.5). 
+PF00672 DUF5;<br>Pfam-B_113 (release 2.1). 
+PF04849 HAP1 N-terminal conserved region<br>Pfam-B_4571 (release 7.6). This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear [1-3]. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34  .. 
+PF02184 HAT (Half-A-TPR) repeat<br>Alignment kindly provided by SMART. The HAT (Half A TPR) repeat is found in several RNA processing proteins  .. 
+PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase<br>SMART, Griffiths-Jones SR. This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.. 
+PF00955 Anion_Exchanger; <br>HCO3- transporter family. Pfam-B_1004 (release 3.0). This family contains Band 3 anion exchange proteins that exchange CL-/HCO3- such as Swiss:P48751. This family also includes cotransporters of Na+/HCO3- such as Swiss:O15153.. 
+PF01966 HD domain<br>HD domains are metal dependent phosphohydrolases.. 
+PF00271 helicase_C; <br>Helicase conserved C-terminal domain. The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.. 
+PF02602 Uroporphyrinogen-III synthase HemD<br>This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea.  This enzyme catalyses the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O.  Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with Pfam:PF00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway  . Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease  .. 
+PF00173 heme_1; <br>Cytochrome b5-like Heme/Steroid binding domain. This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors such as Swiss:O00264 [1,2]. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases.  There is no known ligand for this domain in the chitin synthases.. 
+PF01814 Hemerythrin HHE cation binding domain<br>Iteration of the HHE family ( ) found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain ( ) in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organism from toxicity ( ). However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands ( ). In Staphylococcus aureus P72360 has been noted to be important when the organism switches to living in environments with low oxygen concentrations ( ); perhaps this protein acts as an oxygen store or scavenger.. 
+PF00353 hemolysinCabind; <br>Hemolysin-type calcium-binding repeat (2 copies). 
+PF00132 hexapep; <br>Bacterial transferase hexapeptide (six repeats). 
+PF03129 Anticodon binding domain<br>This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases   it is probably the anticodon binding domain  .. 
+PF03578 HGWP repeat<br>Pfam-B_220 (release 7.0). This short (30 amino acids) repeat is found in a number of plant proteins. It contains a conserved HGWP motif, hence its name. The function of these proteins is unknown.. 
+PF00633 Helix-hairpin-helix motif<br>The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA  . The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain  .. 
+PF01079 Hint module<br>Pfam-B_766 (release 3.0). This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module. . 
+PF01634 ATP phosphoribosyltransferase<br>Pfam-B_1142 (release 4.1). 
+PF00512 signal; <br>His Kinase A (phospho-acceptor) domain. Dimerisation and phospho-acceptor domain of histidine kinases.. 
+PF00850 Histone deacetylase domain<br>Pfam-B_343 (release 3.0). Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism.  Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins  .. 
+PF00010 Helix-loop-helix DNA-binding domain<br>
+PF00403 Heavy-metal-associated domain<br>
+PF00368 HMG-CoA_red1;<br>Hydroxymethylglutaryl-coenzyme A reductase. The HMG-CoA reductases catalyse the conversion of HMG-CoA to mevalonate, which is the rate-limiting step in the synthesis of isoprenoids like cholesterol. Probably because of the critical role of this enzyme in cholesterol homeostasis, mammalian HMG-CoA reductase is heavily regulated at the transcriptional, translational, and post-translational levels  .. 
+PF02301 MAD2; <br>The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.. 
+PF00104 hormone_rec; <br>Ligand-binding domain of nuclear hormone receptor. This all helical domain is involved in binding the hormone in these receptors.. 
+PF03241 4-hydroxyphenylacetate 3-hydroxylase C terminal<br>Pfam-B_3148 (release 6.5). HpaB Swiss:Q57160 encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli  . HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This family also includes PvcC Swiss:O30372 may play a role in one of the proposed hydroxylation steps of pyoverdine chromophore biosynthesis  . . 
+PF02185 Hr1 repeat<br>Alignment kindly provided by SMART. 
+PF00570 HRDC domain<br>The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains  .. 
+PF03878 Hrf1; <br>YIF1 (Yip1 interacting factor) is an integral membrane protein that is required for membrane fusion of ER derived vesicles  . It also plays a role in the biogenesis of ER derived COPII transport vesicles  .. 
+PF02793 Hormone receptor domain<br>This extracellular domain contains four conserved cysteines that probably for disulphide bridges.  The domain is found in a variety of hormone receptors. It may be a ligand binding domain. . 
+PF01381 Helix-turn-helix<br>This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family  .. 
+PF01402 Ribbon-helix-helix protein, copG family<br>The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement  . The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected  .. 
+PF02954 Bacterial regulatory protein, Fis family<br>
+PF04005 Hus1-like protein<br>Pfam-B_12502 (release 7.3). Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo  . Hus1-Rad1-Rad9 complex may form a PCNA-like ring structure, and could function as a sliding clamp during checkpoint control. . 
+PF03810 IBN_NT; <br>Importin-beta N-terminal domain. 
+PF01485 IBR domain<br>The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (Pfam:PF00097).  This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain  .  Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms.  RBR family members play roles in protein quality control and can indirectly regulate transcription  .  Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes.  The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease   .. 
+PF01614 Bacterial transcriptional regulator<br>Pfam-B_755 (release 4.1). 
+PF04760 Translation initiation factor IF-2, N-terminal region<br>This conserved feature at the N-terminus of bacterial translation initiation factor IF2 has recently had its structure solved.  It shows structural similarity to the tRNA anticodon Stem Contact Fold domains of the methionyl-tRNA and glutaminyl-tRNA synthetases, and a similar fold is also found in the B5 domain of the phenylalanine-tRNA synthetase.. 
+PF05198 Translation initiation factor IF-3, N-terminal domain<br>Pfam-B_629 (release 2.1). 
+PF05004 Interferon-related developmental regulator (IFRD)<br>Pfam-B_4730 (release 7.6). Interferon-related developmental regulator (IFRD1) is the human homologue of the rat early response protein PC4 and its murine homologue TIS7  .  The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis  .. 
+PF00817 impB/mucB/samB family<br>Pfam-B_1349 (release 2.1). These proteins are involved in UV protection (Swiss).. 
+PF04836 Interferon-related protein conserved region<br>Pfam-B_4453 (release 7.6). Family of proteins thought to be involved in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF  .. 
+PF04762 IKI3 family<br>Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation  . This region contains WD40 like repeats.. 
+PF00478 IMP dehydrogenase / GMP reductase domain<br>This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel  structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel  . This family is a member of the common phosphate binding site TIM barrel family.. 
+PF03941 Inner centromere protein, ARK binding region<br>Wood V, Griffiths-Jones SR. Pfam-B_67765 (release 7.2). This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of  chromosome segregation with cell division in yeast.. 
+PF04179 Initiator tRNA phosphoribosyl transferase <br>Pfam-B_16986 (release 7.3);. This enzyme (EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the  modification donor. As the initiator tRNA participates both in the  initiation and elongation of translation, the 2'-O-ribosyl phosphate  modification discriminates the initiator tRNAs from the elongator  tRNAs  .. 
+PF02022 Integrase Zinc binding domain<br>Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  This domain is the amino-terminal domain zinc binding domain. The central domain is the catalytic domain Pfam:PF00665. The carboxyl terminal domain is a  DNA binding domain Pfam:PF00552.. 
+PF00520 ion_trans; <br>Ion transport protein. Pfam-B_33 (release 1.0). This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is  repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices. 
+PF03770 Inositol polyphosphate kinase <br>Pfam-B_1382 (release 7.0). ArgRIII has has been demonstrated to be an inositol polyphosphate kinase  . . 
+PF00612 IQ calmodulin-binding motif<br>Ponting C, Schultz J, Bork P. Calmodulin-binding motif.. 
+PF01007 Inward rectifier potassium channel<br>Pfam-B_18 (release 3.0). 
+PF02174 PTB domain (IRS-1 type)<br>
+PF02922 isoamylase_N; Isoamylase_N; <br>Carbohydrate-binding module 48 (Isoamylase N-terminal domain). This domain is found in a range of enzymes that act on branched substrates - isoamylase, pullulanase and branching enzyme. This family also contains the beta subunit of 5' AMP activated kinase.. 
+PF00857 Isochorismatase family<br>Pfam-B_566 (release 3.0). This family are hydrolase enzymes.. 
+PF02373 jmjC; <br>JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily  . JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification  . This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation  .. 
+PF02099 Josephin<br>
+PF02214 K_tetra;<br>Pfam-B_27 (Release 5.2). In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels  . In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor  . It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].. 
+PF02705 K+_trans; <br>K+ potassium transporter. Pfam-B_677 (release 5.5). This is a family of K+ potassium transporters that are conserved across phyla, having both bacterial (KUP) Swiss:P30016  , yeast (HAK)  Swiss:P50505  , and plant (AtKT) Swiss:O22397   sequences as members.. 
+PF01920 KE2; <br>This family includes prefoldin subunits that are not detected by Pfam:PF02996.. 
+PF01344 Kelch motif<br>The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase   for which a structure has been solved  . The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.. 
+PF00013 KH-domain; KH; <br>KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.. 
+PF00109 Beta-ketoacyl synthase, N-terminal domain<br>The structure of beta-ketoacyl synthase is similar to that of the  thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.  The N-terminal domain contains most of  the structures involved in dimer formation and also the active site  cysteine  .. 
+PF02801 ketoacyl-synt_C; <br>Beta-ketoacyl synthase, C-terminal domain. The structure of beta-ketoacyl synthase is similar to that of the  thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.. 
+PF00225 kinesin; <br>Kinesin motor domain. 
+PF00467 L24;Ribosomal_L24;<br>This family has been extended to coincide with ref  . The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.. 
+PF01352 KRAB box<br>The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation  .. 
+PF05178 Krr1; <br>Pfam-B_8372 (release 7.7). The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus  .. 
+PF02735 ku; <br>Ku70/Ku80 beta-barrel domain. The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 Swiss:P12956 and Ku80 Swiss:P13010 proteins that form a DNA binding heterodimer  .. 
+PF03730 Ku70/Ku80 C-terminal arm<br>The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C terminal arm. This alpha helical region embraces the beta-barrel domain Pfam:PF02735 of the opposite subunit  .. 
+PF03731 Ku70/Ku80 N-terminal alpha/beta domain<br>The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the amino terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface.  The domain comprises a six stranded beta sheet of the Rossman fold  .. 
+PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain<br>Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich  alpha+beta fold. BPTI (bovine pancreatic trypsin  inhibitor) is an extensively studied model structure. Certain family members are similar to the tick  anticoagulant peptide (TAP, Swiss:P17726). This is a  highly selective inhibitor of factor Xa in the blood  coagulation pathways  . TAP molecules are highly  dipolar  , and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha  helix  .. 
+PF03521 Kv21channel; <br>Kv2 voltage-gated K+ channel. 
+PF02828 L27 domain<br>Alignment kindly provided by SMART. The L27 domain is found in receptor targeting proteins Lin-2 and Lin-7.. 
+PF02448 L71 family<br>Pfam-B_1976 (release 5.4). This family of insect proteins are each about 100 amino acids long and have 6 conserved cysteine residues. They all have a predicted signal peptide and are probably excreted. The function of the proteins is unknown  .. 
+PF00753 lactamase_B; <br>Metallo-beta-lactamase superfamily. 
+PF02652 L-lactate permease<br>L-lactate permease is an integral membrane protein probably involved in L-lactate transport  .. 
+PF03798 LAG1;<br>Pfam-B_1398 (release 7.0). 
+PF03161 LAGLIDADG DNA endonuclease family<br>Pfam-B_3225 (release 6.5). This is a family of site-specific DNA endonucleases encoded by DNA mobile elements. Similar to Pfam:PF00961, the members of this family are also LAGLIDADG endonucleases.. 
+PF04916 Laminin_A; <br>Pfam-B_5721 (release 7.6). Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids.  This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast  .  In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina  .. 
+PF04031 Las1-like <br>Pfam-B_10636 (release 7.3);. Las1 is an essential nuclear protein involved in cell  morphogenesis and cell surface growth  .. 
+PF00057 ldl_recept_a;<br>Low-density lipoprotein receptor domain class A. Swissprot_feature_table. 
+PF02987 LEA; <br>Late embryogenesis abundant protein. Pfam-B_106 (release 6.4). Different types of LEA proteins are expressed at different  stages of late embryogenesis in higher plant seed embryos  and under conditions of dehydration stress.  The function of  these proteins is unknown.. 
+PF04004 Leo1-like protein<br>Pfam-B_11226 (release 7.3). Members of this family are part of the Paf1/RNA polymerase II complex [1,2]. The Paf1 complex probably functions during the elongation phase of transcription  . The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors  .. 
+PF00060 lig_chan; <br>Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.. 
+PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase<br>
+PF03893 Lipase 3 N-terminal region<br>N terminal region to Pfam:PF01764, found on a subset of Lipase 3 containing proteins. . 
+PF01764 Lipase (class 3)<br>Pfam-B_893 (release 4.2). 
+PF04571 lipin_N; <br>lipin, N-terminal conserved region. Pfam-B_4929 (release 7.5). Mutations in the lipin gene lead to fatty liver dystrophy in mice.  The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserved region is found at the N-terminus of the member proteins [1,2].. 
+PF03180 NLPA lipoprotein<br>Pfam-B_1418 (release 6.5). This family of bacterial lipoproteins contains several antigenic members, that may be involved in bacterial virulence. Their precise function is unknown. However they are probably distantly related to Pfam:PF00497 which are solute binding proteins.. 
+PF02190 ATP-dependent protease La (LON) domain<br>Alignment kindly provided by SMART. This domain has been shown to be part of the PUA superfamily  .. 
+PF00560 LRR; <br>CAUTION: This Pfam may not find all Leucine Rich Repeats in a protein.  Leucine Rich Repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations.  These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.. 
+PF01463 Leucine rich repeat C-terminal domain<br>Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.. 
+PF04180 Low temperature viability protein <br>Pfam-B_15065 (release 7.3);. The low-temperature viability protein LTV1 is involved in ribosome  biogenesis 40S subunit production  .. 
+PF02123 Viral RNA-directed RNA-polymerase<br>IPR001795 & Pfam-B_6212 (release 8.0) & Pfam-B_9867 (release 8.0). This family includes RNA-dependent RNA polymerase proteins  (RdRPs) from Luteovirus, Totivirus and Rotavirus.. 
+PF01476 PG_binding_2; <br>The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation  .  This domain may have a general peptidoglycan binding function. The structure of this domain is known  .. 
+PF03466 LysR substrate binding domain<br>The structure of this domain is known and is similar to the periplasmic binding proteins  .. 
+PF03816 Cell envelope-related transcriptional attenuator domain<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02847 MA3 domain<br>Alignment kindly provided by SMART. Domain in DAP-5, eIF4G, MA-3 and other proteins.  Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains  .. 
+PF01454 MAGE family<br>Prodom_3141 (release 99.1). The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown.  This family also contains the yeast protein, Nse3.  The Nse3 protein is part of the Smc5-6 complex [2-3]. Nse3 has been demonstrated to be important for meiosis .. 
+PF00390 Malic enzyme, N-terminal domain<br>
+PF03949 malic_N; <br>Malic enzyme, NAD binding domain. 
+PF00629 MAM domain<br>An extracellular domain found in many receptors.. 
+PF03999 Microtubule associated protein (MAP65/ASE1 family)<br>Pfam-B_12512 (release 7.3). 
+PF00917 MATH domain<br>Pfam-B_1602 (release 3.0). This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans  .. 
+PF01429 Methyl-CpG binding domain<br>The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs  .  DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair  . MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase  .. 
+PF03062 MBOAT, membrane-bound O-acyltransferase family<br>Pfam-B_2359 (release 6.4). The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue  .. 
+PF02820 mbt;<br>Pfam-B_526 (Release 6.2). The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.. 
+PF02470 mce; <br>Pfam-B_475 (release 5.4). This family of proteins contains the mce (mammalian cell entry) proteins from Mycobacterium tuberculosis. The archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage  . This family contains proteins of  unknown function from other bacteria.. 
+PF05053 Menin<br>Pfam-B_5848 (release 7.7). MEN1, the gene responsible for multiple endocrine neoplasia type 1, is a tumour suppressor gene that encodes a protein called Menin which may be an atypical GTPase stimulated by nm23 .. 
+PF00149 STphosphatase; <br>Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases  , including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.. 
+PF01420 Type I restriction modification DNA specificity domain<br>This domain is also known as the target recognition domain (TRD). Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification.  The host genome is protected from cleavage by methylation of specific nucleotides in the target sites.  In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity subunit (this family), two modification (M) subunits and two restriction (R) subunits  .. 
+PF01795 DUF36; UPF0117;<br>MraW methylase family. Pfam-B_1376 (release 4.2). Members of this family are probably SAM dependent methyltransferases based on Swiss:P18595  . This family appears to be related to Pfam:PF01596.. 
+PF05060 N-acetylglucosaminyltransferase II (MGAT2)<br>Pfam-B_6001 (release 7.7). UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides  . Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency,  unrelated to coagulation factors  .. 
+PF02142 Methylglyoxal_synth; <br>Pfam-B_220 (Release 4.4). This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the  allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site  .. 
+PF01769 Divalent cation transporter<br>
+PF00993 Class II histocompatibility antigen, alpha domain<br>Pfam-B_1288 (release 3.0). 
+PF00969 Class II histocompatibility antigen, beta domain<br>Pfam-B_331 (release 3.0). 
+PF02816 MHCK_EF2_kinase;<br>This family is a novel family of eukaryotic protein kinase catalytic  domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases [1,2] and Elongation Factor-2 kinase and a bifunctional ion channel  . This family is known as the alpha-kinase family  . The structure of the kinase domain   revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.. 
+PF02854 MIF4G domain<br>Alignment kindly provided by SMART. MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G).  Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA  .. 
+PF02815 MIR domain<br>Ponting CP (EMBL archive). The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function  .. 
+PF04212 MIT (microtubule interacting and transport) domain<br>The MIT domain forms an asymmetric three-helix bundle   and binds ESCRT-III (endosomal sorting complexes required for transport) substrates  .. 
+PF00153 mito_carr;<br>Mitochondrial carrier protein. 
+PF03637 Mob1/phocein family<br>Pfam-B_1830 (release 7.0). Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature  . This family also includes phocein Swiss:Q9QYW3, a rat protein that by yeast two hybrid interacts with striatin  .. 
+PF00994 Probable molybdopterin binding domain<br>Pfam-B_1258 (release 3.0). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation  .. 
+PF03454 MoeA C-terminal region (domain IV)<br>This domain is found in  proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known   and forms an incomplete beta barrel.. 
+PF03453 MoeA N-terminal region (domain I and II)<br>This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.. 
+PF02493 MORN repeat<br>The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).\. A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii  .  It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton  .. 
+PF03476 MOSC N-terminal beta barrel domain<br>Aravind L, Anantharaman V. This domain is found to the N-terminus of Pfam:PF03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.. 
+PF04643 motilin_assoc; <br>Motilin/ghrelin-associated peptide. Pfam-B_5485 (release 7.5). This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.. 
+PF04644 motilin_ghrelin; <br>Pfam-B_5485 (release 7.5). Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas  . This family also includes ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system  .. 
+PF01398 Mov34; JAMM;<br>JAB1/Mov34/MPN/PAD-1 ubiquitin protease. Pfam-B_738 (release 3.0). Members of this family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This family is also known as the MPN domain   and PAD-1-like domain  , JABP1 domain   or JAMM domain  .  These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes  . Versions of the domain in prokaryotic  cognates of the ubiquitin-modification pathway are predicted to have  a similar role  . . 
+PF01853 MOZ/SAS family<br>Pfam-B_3994 (Release 4.3). This region of these proteins has been suggested to be homologous to acetyltransferases  .. 
+PF04117 Mpv17 / PMP22 family <br>Pfam-B_8493 (release 7.3);. The 22-kDa peroxisomal membrane protein (PMP22) is a major component of peroxisomal membranes. PMP22 seems to be involved in pore forming activity and may contribute to the unspecific permeability of the organelle membrane. PMP22 is synthesised on free cytosolic ribosomes and then directed to the peroxisome membrane by specific targeting information  . Mpv17 is a closely related peroxisomal protein. In mouse, the Mpv17 protein is involved in the development of early-onset glomerulosclerosis  .  More recently a homolog of Mpv17 in S. cerevisiae has been been found to be an integral membrane protein of the inner mitochondrial membrane where it has been proposed to have a role in ethanol metabolism and tolerance during heat-shock  . Defects in MPV17 is associated with mitochondrial DNA depletion syndrome (MDDS) and Navajo neurohepatopathy (NNH)   .  MDDS is a clinically heterogeneous group of disorders characterised by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.  Individuals with the hepatocerebral form of mitochondrial DNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.  NNH is an autosomal recessive disease that is prevalent among Navajo children in the South Western states of America.  The major clinical features are hepatopathy, peripheral neuropathy, corneal anesthesia and scarring, acral mutilation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Infantile, childhood, and classic forms of NNH have been described. Mitochondrial DNA depletion was detected in the livers of patients, suggesting a primary defect in mtDNA maintenance  .. 
+PF03587 Mra1; Nep1; <br>EMG1/NEP1 methyltransferase. Pfam-B_3290 (release 7.0). Members of this family are essential for 40S ribosomal biogenesis.  The structure of EMG1 has revealed that it is a novel member of the superfamily of alpha/beta knot fold methyltransferases  .. 
+PF03022 Major royal jelly protein<br>Pfam-B_1099 (release 6.4). Royal jelly is the food of queen bee larvae, and is responsible for the high reproductive ability of the queen.  Major royal jelly  proteins make up around 90% of larval jelly proteins.   This family also the sequence-related yellow protein of drosophila  which controls pigmentation of the adult cuticle and larval mouth  parts.. 
+PF04707 MSF1; <br>Pfam-B_5792 (release 7.5). This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.. 
+PF00635 MSP_domain; <br>MSP (Major sperm protein) domain. Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.. 
+PF03820 Tricarboxylate carrier<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00249 myb_DNA-binding; <br>Myb-like DNA-binding domain. This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family  .. 
+PF02736 Myosin N-terminal SH3-like domain<br>Pfam-B_110 (Release 5.5). This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.. 
+PF00784 MyTH4 domain<br>Alignment kindly provided by SMART. Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.. 
+PF03485 N-Arg; <br>Arginyl tRNA synthetase N terminal domain. This domain is found at the amino terminus of Arginyl  tRNA synthetase, also called additional domain 1 (Add-1). It is about 140 residues long and it has been suggested that this domain will be involved in tRNA recognition  .. 
+PF01699 Na_Ca_Ex; <br>Sodium/calcium exchanger protein. Pfam-B_1680 (release 4.1). This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells  . Ca2+ is moved into or out of the cytosol depending on Na+ concentration  .  In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3   see Swiss:Q01728, Swiss:P48768 and Swiss:P70549 respectively.. 
+PF00999 Sodium/hydrogen exchanger family<br>Pfam-B_312 (release 3.0). Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus.\. The transmembrane regions M3-M12 share identity with other members of the family.  The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions.  The cytoplasmic region has little similarity throughout the family.. 
+PF02690 Na+/Pi-cotransporter<br>Pfam-B_509 (release 5.5). This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of  which are also Na+/Pi-cotransporters.  In the kidney the type II renal  Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the  proximal tubule  .. 
+PF02445 Quinolinate synthetase A protein<br>Pfam-B_1915 (release 5.4). Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid  . This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein".. 
+PF03822 NAF domain<br>
+PF05089 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain<br>Pfam-B_6295 (release 7.7). Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate  . Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations  . The structure shows that the enzyme is composed of three domains.  This central domain has a tim barrel fold  .. 
+PF02365 No apical meristem (NAM) protein<br>Pfam-B_530 (release 5.2). This is a family of no apical meristem (NAM) proteins these are plant development proteins.  Mutations in NAM result in the failure to develop a shoot apical meristem in petunia embryos  .  NAM is indicated as having a role in determining positions of meristems and primordial  . One member of this family NAP (NAC-like, activated by AP3/PI) is encoded by the target genes of the AP3/PI transcriptional activators and functions in the transition between growth by cell division and cell expansion in stamens and petals  .. 
+PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family<br>Pfam-B_5038 (release 7.3) & Pfam-B_5422 (Release 7.5). Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in  the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase Pfam:PF01729.. 
+PF04970 NC;<br>Lecithin retinol acyltransferase. Pfam-B_3758 (release 7.0). The full-length members of this family, eg Swiss:P53816, are representatives of a novel class II tumour-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localisation, but not necessary for the enzyme activity  .  H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyses the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester  .. 
+PF04904 NAB conserved region 1 (NCD1)<br>Pfam-B_6188 (release 7.6). Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors  . This region consists of the N-terminal NAB conserved region 1, which  interacts with the EGR1 inhibitory domain (R1)  .  It may also mediate multimerisation.. 
+PF04905 NAB conserved region 2 (NCD2)<br>Pfam-B_6188 (release 7.6). Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors  . This family consists of NAB conserved region 2, near the C-terminus of the protein.  It is necessary for transcriptional repression by the Nab  proteins  .  It is also required for transcription activation by Nab  proteins at Nab-activated promoters  .. 
+PF03096 Ndr family<br>Pfam-B_2481 (release 6.4). 
+PF03102 NeuB family<br>Pfam-B_2572 (release 6.4). NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This reaction has only been observed in prokaryotes; eukaryotes synthesise the 9-phosphate form, Neu5Ac-9-P, and utilise ManNAc-6-P instead of ManNAc. Such eukaryotic enzymes are not present in this family  . This family also contains SpsE spore coat polysaccharide biosynthesis proteins.. 
+PF02931 Neurotransmitter-gated ion-channel ligand binding domain<br>This family is the extracellular ligand binding domain of these ion channels  .  This domain forms a pentameric arrangement in the known structure.. 
+PF01436 NHL repeat<br>The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies.  It is about 40 residues long and resembles the WD repeat Pfam:PF00400.  The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localised to the repeats  . Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats  .. 
+PF03031 NLI interacting factor-like phosphatase<br>Pfam-B_1405 (release 6.4). This family contains a number of NLI interacting factor isoforms (eg. Swiss:Q9PTJ8) and also an N-terminal regions of RNA polymerase II CTC phosphatase (Swiss:Q9Y5BO) and FCP1 serine phosphatase (Swiss:Q9PT70). This region has been identified as the minimal phosphatase domain  .. 
+PF04923 Ninjurin <br>Pfam-B_5824 (release 7.6). Ninjurin (nerve injury-induced protein) is involved in nerve regeneration and in the formation and function in some tissues  .. 
+PF02613 Nitrate reductase delta subunit<br>This family is the delta subunit of the nitrate reductase enzyme, The delta subunit is not part of the nitrate reductase enzyme but is most likely needed for assembly of the multi-subunit enzyme complex  .  In the absence of the delta subunit the core alpha beta enzyme complex is unstable  .  The delta subunit is essential for enzyme activity in vivo and in vitro  .  The nitrate reductase enzyme, EC:1.7.99.4 catalyse the conversion of nitrite to nitrate via the reduction of an acceptor.\.    The nitrate reductase enzyme is composed of three subunits  .\.    Nitrate is the most widely used alternative electron acceptor after oxygen  . This family also now contains the family TorD, a family of cytoplasmic chaperone proteins; like many prokaryotic molybdoenzymes, the TMAO reductase (TorA) of Escherichia coli requires the insertion of a bis(molybdopterin guanine dinucleotide) molybdenum (bis(MGD)Mo) cofactor in its catalytic site to be active and translocated to the periplasm. The TorD chaperone increases apoTorA activation up to four-fold, allowing maturation of most of the apoprotein.   Therefore TorD is involved in the first step of TorA maturation to make it competent to receive the cofactor  .. 
+PF00877 NlpC/P60 family<br>Pfam-B_292 (release 3.0) & Pfam-B_9022 (Release 8.0). The function of this domain is unknown. It is found in several lipoproteins.. 
+PF04981 NMD3 family <br>The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway  .. 
+PF01234 NNMT/PNMT/TEMT family<br>
+PF04147 Nop14-like family <br>Pfam-B_8521 (release 7.3);. Emg1 and Nop14 are novel proteins whose interaction is  required for the maturation of the 18S rRNA and for 40S  ribosome production  .. 
+PF04153 NOT; <br>NOT2 / NOT3 / NOT5 family. Pfam-B_2131 (release 7.3). NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.. 
+PF04065 Not1 N-terminal domain, CCR4-Not complex component <br>Pfam-B_8081 (release 7.3);. 
+PF03060 NPD;<br>Nitronate monooxygenase. Pfam-B_2634 (release 6.4). Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase [1,2,3], but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms  . The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.. 
+PF05021 NPL4 family<br>Pfam-B_13681 (release 7.6). The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome  . Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.. 
+PF01909 DUF76;<br>Nucleotidyltransferase domain. Members of this family belong to a large family of nucleotidyltransferases  . This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.. 
+PF01759 UNC-6/NTR/C345C module<br>Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in  . Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs).  The TIMPs are classified as a separate family in Pfam (Pfam:PF00965)  . This expanded domain family has been named as the NTR module  .. 
+PF04142 Nucleotide-sugar transporter<br>Pfam-B_2311 (release 7.3). This family of membrane proteins transport nucleotide sugars from the cytoplasm into golgi vesicles.  Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.. 
+PF04096 Nucleoporin autopeptidase<br>Pfam-B_5132 (release 7.3);. 
+PF01733 Nucleoside transporter<br>Pfam-B_2135 (release 4.1). This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways  . Also in this family is mouse and human nucleolar protein HNP36 Swiss:Q14542 a protein of unknown function; although it has been hypothesised to be a plasma membrane nucleoside transporter  .. 
+PF04880 NUDE protein, C-terminal conserved region<br>Pfam-B_6501 (release 7.6). This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration  .. 
+PF00293 mutT; <br>
+PF03826 OAR domain<br>
+PF03137 OATP_C;<br>Organic Anion Transporter Polypeptide (OATP) family. Pfam-B_626 (release 6.5). This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al.   initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins (e.g. Swiss:Q92959) are also considered to be OATP family members. In addition, the methotrexate transporter OATK (Swiss:P70502) is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted.  Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.. 
+PF05005 Janus/Ocnus family (Ocnus)<br>Pfam-B_4799 (release 7.6). This family is comprised of the Ocnus, Janus-A and Janus-B proteins. These proteins have been found to be testes specific in Drosophila melanogaster  . . 
+PF00215 Orotidine 5'-phosphate decarboxylase / HUMPS family<br>This family includes Orotidine 5'-phosphate decarboxylase enzymes EC:4.1.1.23 that are involved in the final step of pyrimidine biosynthesis. The family also includes enzymes such as hexulose-6-phosphate synthase. This family appears to be distantly related to Pfam:PF00834.. 
+PF04084 Origin recognition complex subunit 2 <br>Pfam-B_7065 (release 7.3);. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex.  The function of ORC is reviewed in  . . 
+PF03392 Insect pheromone-binding family, A10/OS-D<br>Pfam-B_3032 (release 6.6). 
+PF04756 OST3 / OST6 family<br>The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs  . This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation  .. 
+PF01010 oxidored_q1_C; <br>NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus. Pfam-B_41 (release 3.0). This sub-family represents a carboxyl terminal extension of Pfam:PF00361. It includes subunit 5 from chloroplasts, and bacterial subunit L.  This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.. 
+PF01483 P; <br>Proprotein convertase P-domain. A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain.. 
+PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit<br>Pfam-B_6413 (release 7.3);. The seven component ARP2/3 actin-organising complex is involved in actin assembly and function.. 
+PF02331 Apoptosis preventing protein<br>Pfam-B_13247 (release 5.2). This viral protein functions to block the host apoptotic response  caused by infection by the virus. The apoptosis preventing protein (or early 35kD protein, P35) acts by blocking caspase protease  activity.. 
+PF02225 PA domain<br>Pfam-B_259 (release 5.2). The PA (Protease associated) domain is found as an insert domain in diverse proteases. The PA domain is also found in a plant vacuolar sorting receptor Swiss:O22925 and members of the RZF family Swiss:O43567. It has been suggested that this domain forms a lid-like structure that covers the active site in active proteases, and is involved in protein recognition in vacuolar sorting receptors  .. 
+PF00291 S_T_dehydratase; <br>Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16 Swiss:P04968, tryptophan synthase beta chain EC:4.2.1.20 Swiss:P00932, threonine synthase EC:4.2.99.2 Swiss:P04990, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22 Swiss:P35520, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4 Swiss:P76316.. 
+PF00024 apple; Apple;PAN; <br>The PAN domain   contains a conserved core of three disulphide bridges.  In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.. 
+PF01569 PAP2 superfamily<br>Pfam-B_486 (release 4.0). This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.. 
+PF03828 Cid1 family poly A polymerase<br>Griffiths-Jones SR, Wood V, Mistry J. This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity     . Proteins in this family have been located to both the nucleus and the cytoplasm.. 
+PF04928 Poly(A) polymerase central domain<br>Pfam-B_1341 (release 7.6). The central domain of Poly(A) polymerase shares structural similarity with the allosteric activity domain of ribonucleotide reductase R1, which comprises a four-helix bundle and a three-stranded mixed beta- sheet. Even though the two enzymes bind ATP, the ATP-recognition motifs are different.. 
+PF05028 PARG; <br>Poly (ADP-ribose) glycohydrolase (PARG). Pfam-B_5996 (release 7.6). Poly(ADP-ribose) glycohydrolase (PARG), is a ubiquitously expressed exo-  and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death  .. 
+PF01734 Patatin-like phospholipase<br>Pfam-B_2206 (release 4.1). This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of  the total soluble protein in potato tubers  . Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids  . Members of this family have been found also in vertebrates.. 
+PF02460 Patched family<br>Pfam-B_2400 (release 5.4). The transmembrane protein Patched Swiss:P18502 is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.. 
+PF02170 ZAP;<br>This domain is named PAZ after the proteins Piwi  Argonaut and Zwille. This domain is found in two families of proteins that are involved in post-transcriptional gene silencing. These are the Piwi family and the Dicer family, that includes the Carpel factory protein. The function of the domains is unknown but has been suggested to mediate complex formation between proteins of the Piwi and Dicer families by hetero-dimerisation. The three-dimensional structure of this domain has been solved [2-4]. The PAZ domain is composed of two subdomains. One subdomain is similar to the OB fold, albeit with a different topology. The OB-fold is well known as a single-stranded nucleic acid binding fold. The second subdomain is composed of a beta-hairpin followed by an alpha-helix. The PAZ domains shows low-affinity nucleic acid binding and appears to interact with the 3' ends of single-stranded regions of RNA in the cleft between the two subdomains. PAZ can bind the characteristic two-base 3' overhangs of siRNAs, indicating that although PAZ may not be a primary nucleic acid binding site in Dicer or RISC, it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.. 
+PF00564 OPR;<br>Alignment kindly provided by SMART. 
+PF00786 P21-Rho-binding domain<br>Alignment kindly provided by SMART. Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).. 
+PF01161 Phosphatidylethanolamine-binding protein<br>Prosite & Pfam-B_5394 (Release 7.5). 
+PF01399 PCI domain<br>This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15)  .. 
+PF03462 PCRF domain<br>This domain is found in peptide chain release factors.. 
+PF02153 Prephenate dehydrogenase<br>PSI-BLAST P20692/1-290. Members of this family are prephenate dehydrogenases EC:1.3.1.12 involved in tyrosine biosynthesis.. 
+PF04166 Pyridoxal phosphate biosynthetic protein PdxA<br>TIGRFAMs (release 2.0);. In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesised  de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalysed by  the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate  .. 
+PF00934 PE family<br>Pfam-B_253 (release 3.0). This family named after a PE motif near to the amino terminus of the domain.  The PE family of proteins all contain an amino-terminal region of about 110 amino acids.  The carboxyl terminus of this family are variable and fall into several classes.  The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis  .. 
+PF01095 Pectinesterase<br>
+PF04710 Pellino<br>Pfam-B_5882 (release 7.5). Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase [1,2,3].. 
+PF02452 PemK-like protein<br>Pfam-B_2134 (release 5.4). PemK is a growth inhibitor in E. coli known to bind to the promoter  region of the Pem operon, auto-regulating synthesis. This Pfam family consists of the PemK protein in addition to ChpA, ChpB and other PemK-like proteins. . 
+PF01804 Penicillin amidase<br>Pfam-B_1410 (release 4.2). Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins  . Also in the family is cephalosporin acylase Swiss:P07662 and  Swiss:P29958 aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.. 
+PF01469 Pentapeptide repeats (8 copies)<br>These repeats are found in many mycobacterial proteins.  These repeats are most common in the Pfam:PF00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to Pfam:PF00805  , however it is not clear if these two families are structurally related.. 
+PF00391 PEP-utilising enzyme, mobile domain<br>This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.. 
+PF05131 Pep3/Vps18/deep orange family<br>Pfam-B_6057 (release 7.7). This region is found in a number of protein identified as involved in golgi function and vacuolar sorting. The molecular function of this region is unknown.  The members of this family contain a C-terminal ring finger domain.. 
+PF03051 Pept_C1-like; <br>Peptidase C1-like family. Pfam-B_2136 (release 6.4). This family is closely related to the Peptidase_C1 family  Pfam:PF00112, containing several prokaryotic and eukaryotic aminopeptidases and bleomycin hydrolases.. 
+PF00112 Cys-protease; <br>Papain family cysteine protease. 
+PF01650 Peptidase C13 family<br>Pfam-B_1302 (release 4.1). Members of this family are asparaginyl peptidases  . The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation  . In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified.  This has formerly been characterised as a 'haemoglobinase', but this term is probably incorrect  .  Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue.  Both forms have been recombinantly expressed  .. 
+PF00863 Peptidase family C4<br>Pfam-B_232 (release 3.0). This peptidase is present in the nuclear inclusion protein of potyviruses.. 
+PF02902 Ulp1_C; <br>Ulp1 protease family, C-terminal catalytic domain. This domain contains the catalytic triad Cys-His-Asn.. 
+PF03416 Peptidase family C54<br>
+PF01433 Peptidase family M1<br>Members of this family are aminopeptidases.  The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues.  This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activity  .. 
+PF01431 Peptidase family M13<br>Mammalian enzymes are typically type-II membrane anchored enzymes which are known, or believed to activate or inactivate oligopeptide (pro)-hormones such as opioid peptides. The family also contains a bacterial member believed to be involved with milk protein cleavage.. 
+PF05193 Peptidase M16 inactive domain<br>Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp  .. 
+PF02789 Cytosol aminopeptidase family, N-terminal domain<br>Pfam-B_990 (release 3.0). 
+PF02127 Aminopeptidase I zinc metalloprotease (M18)<br>
+PF01546 CO_pept_M20; <br>Peptidase family M20/M25/M40. Pfam-B_253 (release 4.0). This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification  . Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.. 
+PF00814 Glycoprotease; <br>Glycoprotease family. Pfam-B_1670 (release 2.1) & Pfam-B_4550 (Release 7.5). The Peptidase M22 proteins are part of the HSP70-actin superfamily ( ). The region represented here is an insert into the fold and is not found in the rest of the family (beyond the Peptidase M22 family). Included in this family are the Rhizobial NodU proteins and the HypF regulator. This region also contains the histidine dyad believed to coordinate the metal ion and hence provide catalytic activity. Interestingly the histidines are not well conserved, and there is a lack of experimental  evidence to support peptidase activity as a general  property of this family. There also appear to be instances of this domain outside of the HSP70-actin superfamily (e.g. Swiss:Q9ZM49).. 
+PF04389 Peptidase family M28<br>
+PF01551 Peptidase_M37;<br>Peptidase family M23. Pfam-B_291 (release 4.0). Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins.  LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.. 
+PF01434 Peptidase family M41<br>
+PF02163 Peptidase family M50<br>
+PF02897 Prolyl oligopeptidase, N-terminal beta-propeller domain<br>This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see Pfam:PF00326), excluding larger peptides and proteins from proteolysis in the cytosol.. 
+PF04080 Per1-like <br>Pfam-B_12918 (release 7.3);. PER1 is required for GPI-phospholipase A2 activity and is involved in lipid remodelling of GPI-anchored proteins  .. 
+PF04695 Peroxisomal membrane anchor protein (Pex14p) conserved region<br>Pfam-B_4121 (release 7.5). Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes.  Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein [1,2].. 
+PF00294 pfkB; <br>pfkB family carbohydrate kinase. This family includes a variety of carbohydrate and pyrimidine kinases.. 
+PF00169 PH domain<br>PH stands for pleckstrin homology.. 
+PF05065 Phage capsid family <br>Pfam-B_3186 (release 7.7) & Pfam-B_9481 (release 10.0). Family of bacteriophage hypothetical proteins and capsid proteins. . 
+PF02899 Phage_integr_N;<br>Phage integrase, N-terminal SAM-like domain. 
+PF04860 Phage portal protein<br>Pfam-B_6050 (release 7.6). Bacteriophage portal proteins form a dodecamer and is located at a  five-fold vertex of the viral capsid.  The portal complex forms a channel through which the viral DNA is packaged into the capsid, and exits during  infection.  The portal protein is though to rotate during DNA packaging   . Portal proteins from different phage show little sequence homology, so  this family does not represent all portal proteins.. 
+PF05119 Phage_sml_term; <br>Phage terminase, small subunit. TIGRFAMs (release 2.0);. 
+PF03354 Phage_terminase; <br>Pfam-B_3931 (release 6.5). The majority of the members of this family are bacteriophage proteins, several of which are thought to be terminase large subunit proteins. There are also a number of bacterial proteins of unknown function.. 
+PF00628 PHD-finger<br>PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains  .  Several PHD fingers have been identified as binding modules of methylated histone H3  .. 
+PF01384 Phosphate transporter family<br>Pfam-B_923 (release 3.0). This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter  . This family also contains the leukaemia virus receptor Swiss:Q08344.. 
+PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase<br>Pfam-B_994 (release 4.1) & Pfam-B_6150 (Release 8.0). This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD,  deoxynucleotides and nucleotide sugars  . Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which  exhibits type I phosphodiesterases activity  . The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form  F. odoratum  .. 
+PF02811 PHP_C; <br>The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.. 
+PF02972 phycoerythr_ab; <br>Phycoerythrin, alpha/beta chain. This family represents the non-globular alpha and beta chain components of phycoerythrin.  The structure is a long beta-hairpin and a single alpha-helix.. 
+PF05023 Phytochelatin synthase<br>Pfam-B_9299 (release 7.6). Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols  . The crystal structure of a member of this family shows it to possess a papain fold  . The enzyme catalyses the deglycination of a GSH donor molecule  . The enzyme contains a catalytic triad of cysteine, histidine and aspartate residues.. 
+PF02567 Phenazine biosynthesis-like protein<br>
+PF00454 Phosphatidylinositol 3- and 4-kinase<br>Prosite & Pfam-B_6771 (Rlease 7.6). Some members of this family probably do not have lipid kinase activity and are protein kinases, e.g. Swiss:P42345  .. 
+PF00792 Phosphoinositide 3-kinase C2<br>SMART, Griffiths-Jones SR. Alignment kindly provided by SMART. Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family. . 
+PF00640 Phosphotyrosine interaction domain (PTB/PID)<br>
+PF04987 Phosphatidylinositolglycan class N (PIG-N)<br>Pfam-B_5307 (release 7.6). Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum  . PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localised proteins that serve many important cellular functions  .. 
+PF01850 PIN domain<br>
+PF04696 pinin_SDK_memA; <br>pinin/SDK/memA/ protein conserved region. Pfam-B_4141 (release 7.5). Members of this family have very varied localisations within the eukaryotic cell. pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque  .  SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing  .  memA is a tumour marker preferentially expressed in human melanoma cell lines.  A common feature of the members of this family is that they may all participate in regulating protein-protein interactions  .. 
+PF01504 Phosphatidylinositol-4-phosphate 5-Kinase<br>Pfam-B_571 (release 4.0). This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in  . The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the  phosphorylation of phosphatidylinositol-4-phosphate a precursor in the  phosphinositide signaling pathway.. 
+PF02171 Piwi domain<br>This domain is found in the protein Piwi and its relatives.  The function of this domain is the dsRNA guided hydrolysis of ssRNA. Determination of the crystal structure of Argonaute reveals that PIWI is an RNase H domain, and identifies Argonaute as Slicer, the enzyme that cleaves mRNA in the RNAi RISC complex  .  In addition, Mg+2 dependence and production of 3'-OH and 5' phosphate products are shared characteristics of RNaseH and RISC. The PIWI domain core has a tertiary structure belonging to the RNase H family of enzymes.  RNase H fold proteins all have a five-stranded mixed beta-sheet surrounded by helices. By analogy to RNase H enzymes which cleave single-stranded RNA guided by the DNA strand in an RNA/DNA hybrid, the PIWI domain can be inferred to cleave single-stranded RNA, for example mRNA, guided by double stranded siRNA. . 
+PF00801 PKD domain<br>This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold  .. 
+PF01477 PLAT/LH2 domain<br>This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain.  The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners.\. The structure of this domain is known for many members of the family and is composed of a beta sandwich.. 
+PF00614 Phospholipase D Active site motif<br>Ponting C, Schultz J, Bork P. Alignment kindly provided by SMART. Phosphatidylcholine-hydrolysing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of certain types of transport vesicles or may be constitutive vesicular transport to signal transduction pathways.  PC-hydrolysing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins. Each of these appears to possess a domain duplication which is apparent by the presence of two motifs containing well-conserved histidine, lysine, and/or asparagine residues which may contribute to the active site. aspartic acid.  An E. coli endonuclease (nuc) and similar proteins appear to be PLD homologues but possess only one of these motifs. The profile contained here represents only the putative active site regions, since an accurate multiple alignment of the repeat units has not been achieved.. 
+PF01690 Potato leaf roll virus readthrough protein<br>Pfam-B_1335 (release 4.1). This family consists mainly of the potato leaf roll virus  readthrough protein. This is generated via a readthrough  of open reading frame 3 a coat protein allowing transcription of open reading frame 5 to give an extended coat protein  with a large c-terminal addition or read through domain  . The readthrough protein is thought to play a role in the  circulative aphid transmission of potato leaf roll virus  . Also in the family is open reading frame 6 from beet western yellows virus and potato leaf roll virus both luteovirus and an unknown protein from cucurbit aphid-borne yellows virus a closterovirus.. 
+PF03126 Plus-3 domain<br>This domain is about 90 residues in length and is often found associated with the Pfam:PF02213 domain.  The function of this domain is uncertain. It is possible that this domain is involved in DNA binding as it has three conserved positively charged residues, hence this domain has been named the plus-3 domain. It is found in yeast Rtf1 which may be a transcription elongation factor  .. 
+PF04043 Plant invertase/pectin methylesterase inhibitor<br>This domain inhibits pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex  . It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension (see  ). It may also be involved in inhibiting microbial pathogen PMEs. It has been observed that it is often expressed as a large inactive preprotein  . It is also found at the N-termini of PMEs predicted from DNA sequences (personal obs:C Yeats), suggesting that both PMEs and their inhibitor are expressed as a single polyprotein and subsequently processed. It has two disulphide bridges and is mainly alpha-helical  .. 
+PF04721 PNGase; <br>Domain of unknown function (DUF750) . Pfam-B_4045 (release 7.5). This family of proteins with unknown function shows similarity to PNG-1, a enzyme responsible for de-N-glycosylation of misfolded glycoproteins in the cytosol  . However, unlike PNG-1, this protein does not contain a catalytic triad in its transglutaminase domain  .. 
+PF03726 Polyribonucleotide nucleotidyltransferase, RNA binding domain<br>This family contains the RNA binding domain of Polyribonucleotide nucleotidyltransferase (PNPase) PNPase is involved in mRNA degradation in a 3'-5' direction.. 
+PF01357 Pollen_allergen; <br>This family contains allergens lol PI, PII and PIII from Lolium perenne.. 
+PF01522 Polysac_deacet;Polysacc_deacet; <br>Polysaccharide deacetylase. Pfam-B_502 (release 4.0). This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB (nodulation protein B from  Rhizobium) which is a chitooligosaccharide deacetylase  . It also includes chitin deacetylase from yeast  , and endoxylanases which hydrolyses glucosidic bonds in xylan  .. 
+PF04831 Popeye protein conserved region<br>Pfam-B_3905 (release 7.6). The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains  .. 
+PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase<br>Pfam-B_350 (release 4.0). This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein.  It is not known whether the  gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms  . This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA  . The family also includes  pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited  . . 
+PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg<br>Pfam-B_323 (release 4.2). This family includes the N terminal structural domain of the pyruvate ferredoxin oxidoreductase. This domain binds thiamine diphosphate, and along with domains II and IV, is involved in inter subunit contacts  . The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited  .. 
+PF04151 Bacterial pre-peptidase C-terminal domain<br>
+PF01577 Poty_P1; <br>Potyvirus P1 protease. Pfam-B_364 (release 4.1). The potyviridae family positive stand RNA viruses with genome  encoding a polyprotein. members include zucchini yellow mosaic virus, and turnip mosaic viruses which cause considerable losses of crops  worldwide. This family consists of a C terminus region from various plant potyvirus P1 proteins (found at the N terminus of the polyprotein). The C terminus of P1 is a serine-type protease responsible for  autocatalytic cleavage between P1 and the helper component protease  Pfam:PF00851 [1,2]. The entire P1 protein may be involved in virus-host interactions  .. 
+PF03291 mRNA capping enzyme<br>Pfam-B_4078 (release 6.5) & Pfam-B_3482 (Release 7.5). This family of enzymes are related to Pfam:PF03919.. 
+PF00481 Protein phosphatase 2C<br>Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.. 
+PF00823 PPE family<br>Pfam-B_297 (release 3.0). This family named after a PPE motif near to the amino terminus of the domain.  The PPE family of proteins all contain an amino-terminal region of about 180 amino acids.  The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups.  The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis  .. 
+PF01535 DUF17; <br>Pfam-B_874 (release 4.0). This repeat has no known function. It is about 35 amino acids long and found in up to 18 copies in some proteins.  This family appears to be greatly expanded in plants. This repeat occurs in PET309 Swiss:P32522 that may be involved in RNA stabilisation  . This domain occurs in crp1 that is involved in RNA processing  .  This repeat is associated with a predicted plant protein Swiss:O49549 that has a domain organisation similar to the human BRCA1 protein. The repeat has been called PPR  .. 
+PF04193 PQ loop repeat <br>TIGRFAMs (release 2.0);. Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop  . The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes  . However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue  .. 
+PF05033 Pre-SET motif<br>This protein motif is a zinc binding motif  .  It  contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.. 
+PF00156 Phosphoribosyl transferase domain<br>This family includes a range of diverse phosphoribosyl transferase enzymes.  This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8 Swiss:P36766. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1 Swiss:P09329. Amidophosphoribosyltransferase EC:2.4.2.14 Swiss:P00496. Orotate phosphoribosyl-transferase EC:2.4.2.10 Swiss:P11172. Uracil phosphoribosyl-transferase EC:2.4.2.9 Swiss:P25532. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22 Swiss:P00501.  In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain  .. 
+PF00377 prion; <br>Prion/Doppel alpha-helical domain. The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.. 
+PF00227 proteasome; <br>The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes  . Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria  . The second is call beta-proteobacteria proteasome homologue (BPH)  .. 
+PF03371 PRP38 family<br>Members of this family are related to the pre mRNA splicing  factor PRP38 from yeast  .  Therefore all the members of this family could be involved in splicing.  This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation  . . 
+PF01789 PsbP<br>Pfam-B_1303 (release 4.2). This family consists of the 23 kDa subunit of oxygen evolving system of  photosystem II or PsbP from various plants (where it is encoded by the  nuclear genome) and Cyanobacteria. The 23 KDa PsbP protein is required for PSII to be fully operational in  vivo, it increases the affinity of the water oxidation site for Cl- and  provides the conditions required for high affinity binding of Ca2+  .. 
+PF01416 PseudoU_synt;<br>tRNA pseudouridine synthase. Howe K, Griffiths-Jones SR. Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in  all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.. 
+PF01437 Plexin_repeat;<br>
+PF04046 PSP<br>Pfam-B_PSP (release 7.3);. Proline rich domain found in numerous spliceosome associated proteins.. 
+PF04468 PSP1 C-terminal conserved region<br>This region is present in both eukaryotes and eubacteria. The yeast PSP1 protein is involved in  suppressing mutations in the DNA polymerase alpha subunit in yeast  .. 
+PF04024 PspC domain<br>This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.. 
+PF04886 PT repeat<br>Pfam-B_517 (release 7.6). This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.. 
+PF01329 Pterin 4 alpha carbinolamine dehydratase<br>Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerisation cofactor of hepatocyte nuclear factor 1-alpha).. 
+PF03095 Phosphotyrosyl phosphate activator (PTPA) protein<br>Pfam-B_2456 (release 6.4). Phosphotyrosyl phosphatase activator (PTPA) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. The specific biological role of PTPA is unknown, Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1  .. 
+PF02302 PTS system, Lactose/Cellobiose specific IIB subunit<br>Pfam-B_9339 (release 5.2). The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases.  This family also contains the fructose specific IIB subunit.. 
+PF01472 PUA domain<br>The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes  .  It is predicted that the PUA domain is an RNA binding domain.. 
+PF01480 PWI domain<br>
+PF00787 PX domain<br>Alignment kindly provided by SMART & iterated. PX domains bind to phosphoinositides.. 
+PF02194 PXA domain<br>Alignment kindly provided by SMART. This domain is associated with PX domains Pfam:PF00787.. 
+PF00070 pyr_redox; <br>Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.. 
+PF02852 pyr_redox_dim; <br>Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.. 
+PF01729 QRPTase; <br>Quinolinate phosphoribosyl transferase, C-terminal domain. Pfam-B_2063 (release 4.1). Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other.  The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.. 
+PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain<br>Pfam-B_2063 (release 4.1). Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other.  The N-terminal domain has an alpha/beta hammerhead fold.. 
+PF01424 R3H domain<br>The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues.  The function of the domain is predicted to be binding ssDNA.. 
+PF03834 Binding domain of DNA repair protein Ercc1 (rad10/Swi10)<br>TIGRFAMs, Griffiths-Jones SR, Coggill PC. Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain.  Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex  .. 
+PF04423 Rad50 zinc hook motif<br>The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side.. 
+PF04055 Radical SAM superfamily<br>Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.. 
+PF02145 Rap/ran-GAP<br>
+PF04078 Cell differentiation family, Rcd1-like <br>Pfam-B_5278 (release 7.3);. Two of the members in this family have been characterised as being  involved in regulation of Ste11 regulated sex genes [1,2]. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation  .. 
+PF05177 RCSD region<br>Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.. 
+PF01030 Receptor L domain<br>Pfam-B_244 (release 3.0). The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix  . This Pfam entry is missing the first 50 amino acid residues of the  domain.. 
+PF02010 REJ domain<br>The REJ (Receptor for Egg Jelly) domain is found in PKD1 Swiss:P98161, and the sperm receptor for egg jelly Swiss:Q26627.  The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.. 
+PF03432 Relaxase/Mobilisation nuclease domain <br>Pfam-B_4002 (release 6.6). Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalysing  trans-esterification .    . 
+PF03090 Replicase family<br>Pfam-B_2424 (release 6.4). This is a family of bacterial plasmid DNA replication initiator proteins. Pfam: PF01051 is a similar family.  These RepA proteins exist as monomers and dimers in equilibrium: monomers bind directly to repeated DNA sequences and thus activate replication; dimers repress repA transcription by binding an inversely repeated DNA operator. Dimer dissociation can occur spontaneously or be mediated by Hsp70 chaperones.. 
+PF03248 Rer1 family<br>Pfam-B_3358 (release 6.5). RER1 family protein are involved in involved in the retrieval of some endoplasmic reticulum membrane proteins from the early golgi compartment. The C terminus of yeast Rer1p interacts with a coatomer complex  .. 
+PF02453 Reticulon<br>Pfam-B_2196 (release 5.4). Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.. 
+PF04527 Drosophila Retinin like protein<br>Pfam-B_4914 (release 7.5). Family of Drosophila proteins related to the C-terminal region of the Drosophila Retinin protein. Conserved region is found towards the C-terminus of the member proteins.. 
+PF03732 Retrotransposon gag protein <br>Pfam-B_3194 (release 7.0). Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved  .. 
+PF01694 Rhomboid family<br>Pfam-B_1399 (release 4.1). This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes.\. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor.  Analysis has shown that Rhomboid-1 is an intramembrane serine protease     (EC:3.4.21.105).  Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite  .. 
+PF05104 Ribosome receptor lysine/proline rich region<br>Pfam-B_3249 (release 7.7). This highly conserved region is found towards the C-terminus of the transmembrane domain  . The function is unclear.. 
+PF00636 Ribonuclease III domain<br>
+PF04597 Ribophorin I<br>Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC:2.4.1.119).  OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum.  Ribophorin I and OST48 are though to be responsible for OST catalytic activity  . Both yeast and mammalian proteins are glycosylated but the sites are not conserved.  Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function   Most family members are predicted to have a transmembrane helix at the C terminus of this region.. 
+PF01775 Ribosomal L18ae/LX protein domain<br>This family includes eukaryotic L18ae as well as archaebacterial specific LX.  Ribosomal protein L18ae forms part of the 60S ribosomal subunit.. 
+PF00828 Ribosomal protein L18e/L15<br>Pfam-B_1295 (release 2.1). This family includes eukaryotic L18 as well as prokaryotic L15.. 
+PF01907 Ribosomal protein L37e<br>This family includes ribosomal protein L37 from eukaryotes and archaebacteria. The family contains many conserved cysteines and histidines suggesting that this protein may bind to zinc.. 
+PF00347 L6;<br>Ribosomal protein L6. 
+PF02482 Ribosomal_S30;<br>Sigma 54 modulation protein / S30EA ribosomal protein. Pfam-B_869 (release 5.4). This Pfam family contains the sigma-54 modulation protein family and the S30AE family of ribosomal proteins which includes the light- repressed protein (lrtA) (Swiss:P47908)  .. 
+PF01201 Ribosomal protein S8e<br>
+PF00652 Ricin-type beta-trefoil lectin domain<br>
+PF00355 Rieske [2Fe-2S] domain<br>Prosite & Pfam-B_31 (release 4.1). The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein  .. 
+PF00866 Ring hydroxylating beta subunit<br>Pfam-B_771 (release 3.0). This subunit has a similar structure to NTF-2 and scytalone dehydratase.. 
+PF04068 Possible Fer4-like domain in RNase L inhibitor, RLI<br>Possible metal-binding domain in endoribonuclease RNase L inhibitor.  Found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, fer4, Pfam:PF00037. Also often found adjacent to the DUF367 domain Pfam:PF04034 in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons  , and could possibly play a more general role in the regulation of RNA stability in mammalian cells.  Inhibitory activity requires concentration-dependent association of RLI with RNase L  .. 
+PF04437 RINT-1 / TIP-1 family<br>This family includes RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control  , as well as the TIP-1 protein from yeast that seems to be involved in a complex with Sec20p that is required for golgi transport  .. 
+PF01163 RIO1 family<br>This is a family of atypical serine kinases which are found in archaea, bacteria and eukaryotes.\.       Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome maintenance.  The structure of RIO1 has been determined  .. 
+PF01000 RNA polymerase Rpb3/RpoA insert domain<br>Pfam-B_172 (release 3.0). Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal. 
+PF04997 RNA polymerase Rpb1, domain 1<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 1, represents  the clamp domain, which a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [1,2]. . 
+PF00623 RNA polymerase Rpb1, domain 2<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 2, contains the active site. The invariant motif -NADFDGD- binds the active site magnesium ion [1,2].. 
+PF04983 RNA polymerase Rpb1, domain 3<br>Pfam-B_288 (release 4.2). RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking [1,2].. 
+PF05000 RNA polymerase Rpb1, domain 4<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 4, represents the funnel domain.  The funnel contain the binding site for some elongation factors [1,2].. 
+PF04998 RNA polymerase Rpb1, domain 5<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound [1,2].. 
+PF04992 RNA polymerase Rpb1, domain 6<br>Pfam-B_288 (release 4.2). RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module [1,2].  This family appears to be specific to the largest subunit of RNA polymerase II.. 
+PF05001 RNA polymerase Rpb1 C-terminal repeat <br>The repetitive C-terminal domain (CTD) of Rpb1 (RNA polymerase Pol II) plays a critical role in the regulation of gene expression. The activity of the CTD is dependent on its state of phosphorylation  .. 
+PF04565 RNA polymerase Rpb2, domain 3<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site  .. 
+PF04567 RNA polymerase Rpb2, domain 5<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain  .. 
+PF00562 RNA polymerase Rpb2, domain 6<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain  .  The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex.  This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion .  This domain is also involved in binding to Rpb1 and Rpb3  .  Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).. 
+PF04560 RNA polymerase Rpb2, domain 7<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  Rpb2 is the second largest subunit of the RNA polymerase.  This domain comprised of the structural domains anchor and clamp  . The clamp region (C-terminal) contains a zinc-binding motif  . The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription  .. 
+PF03874 RNA polymerase Rpb4<br>This family includes the Rpb4 protein.  This family also includes C17 (aka CGRP-RCP) is an essential subunit of RNA polymerase III. C17 forms a subcomplex with C25   which is likely to be the counterpart of subcomplex Rpb4/7 in Pol II  .. 
+PF01351 Ribonuclease HII<br>
+PF01138 3' exoribonuclease family, domain 1<br>This family includes 3'-5' exoribonucleases.  Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction.  The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA.  Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain  . Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.. 
+PF03725 3' exoribonuclease family, domain 2<br>This family includes 3'-5' exoribonucleases.  Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction.  The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA.  Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain  . Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.. 
+PF02755 RPEL repeat<br>The RPEL repeat is named after four conserved amino acids it contains. The function of the RPEL repeat is unknown however it might be a DNA binding repeat based on the observation that Swiss:Q9VZY2 contains a Pfam:PF02037 domain that is also implicated in DNA binding.. 
+PF04059 rrm_2; <br>RNA recognition motif 2. Pfam-B_4981 (release 7.3);. 
+PF01137 RCT; <br>RNA 3'-terminal phosphate cyclase. RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate  . The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids  . . 
+PF05189 RNA 3'-terminal phosphate cyclase (RTC), insert domain<br>RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate  . The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids  . . 
+PF00301 rubredoxin; <br>
+PF02759 RUN domain<br>This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases  .. 
+PF00853 Runt domain<br>
+PF00665 Integrase core domain<br>Pfam-B_10 (release 2.1). Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site  .. 
+PF00077 rvp; <br>Retroviral aspartyl protease. Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam:PF00026).. 
+PF00078 rvt; RVT; <br>Reverse transcriptase (RNA-dependent DNA polymerase). Published_alignment and HMM_iterative_training. A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.. 
+PF03501 Plectin/S10 domain<br>Pfam-B_2138 (release 7.0). This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.. 
+PF01479 S4 domain<br>The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation  . The S4 domain probably mediates binding to RNA.. 
+PF04382 SAB domain<br>This presumed domain is found in proteins containing FERM domains Pfam:PF00373.  This domain is found to bind to both spectrin and actin, hence the name SAB (Spectrin and Actin Binding) domain.. 
+PF03399 SAC3/GANP/Nin1/mts3/eIF-3 p25 family<br>Pfam-B_2845 (release 6.6) & Pfam-B_4388 (release 7.5). This large family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins.  The family includes the yeast nuclear export factor Sac3 Swiss:P46674, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localisation of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.  The 26S protease (or 26S proteasome) is responsible for degrading ubiquitin conjugates. It consists of 19S regulatory complexes associated with the ends of 20S proteasomes. The 19S regulatory complex is composed of about 20 different polypeptides and confers ATP-dependence and substrate specificity to the 26S enzyme.  The conserved region occurs at the C-terminal of the Nin1-like regulatory subunit [4,5,6].  This family includes several eukaryotic translation initiation factor 3 subunit 11 (eIF-3 p25) proteins. Eukaryotic initiation factor 3 (eIF3) is a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits  .. 
+PF03435 Saccharopine dehydrogenase <br>Pfam-B_4166 (release 6.6) & Pfam-B_6325 (Release 7.5). This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase.  The saccharopine dehydrogenase can also function as a saccharopine reductase.. 
+PF00536 SAM_1;<br>SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.. 
+PF02198 Sterile alpha motif (SAM)/Pointed domain<br>Alignment kindly provided by SMART. 
+PF01342 SAND domain<br>The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerisation  . This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri.  This region of RegA is known as the VARL domain  .. 
+PF02037 SAP domain<br>The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.. 
+PF05184 Saposin-like type B, region 1<br>
+PF03489 Surfactant_B;<br>Saposin-like type B, region 2. 
+PF04499 SIT4 phosphatase-associated protein<br>Pfam-B_2011 (release 7.5). This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.. 
+PF04000 Sas10/Utp3/C1D family<br>Pfam-B_6555 (release 7.3). This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex   . It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs  , and Sas10 which has been identified as a regulator of chromatin silencing  . This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein  .. 
+PF01547 SBP_bacterial_1; <br>Bacterial extracellular solute-binding protein. Pfam-B_269 (release 4.0). This family also includes the bacterial extracellular solute-binding protein family POTD/POTF.. 
+PF00497 Bacterial extracellular solute-binding proteins, family 3<br>
+PF04144 SCAMP family<br>Pfam-B_1298 (release 7.3). In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain proteins to the N-terminal NPF repeats but may have additional functions mediated by their other sequences  .. 
+PF02023 SCAN domain<br>Pfam-B_1614 (Release 5.0). The SCAN domain   (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several Pfam:PF00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerisation  .. 
+PF02404 Stem cell factor<br>Pfam-B_2598 (release 5.4). Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified  . . 
+PF00188 SCP;<br>Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes   and non-vertebrate eukaryotes  , The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins.  Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences  . The Ca++-chelating function   would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.. 
+PF03803 Scramblase <br>Pfam-B_3893 (release 7.0). Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site.  Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury  .. 
+PF01390 SEA domain<br>Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain  .. 
+PF04091 Exocyst complex subunit Sec15-like <br>Pfam-B_7871 (release 7.3);. 
+PF04815 Sec23/Sec24 helical domain<br>Pfam-B_3055 (release 7.3). COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.. 
+PF04811 Sec23/Sec24 trunk domain<br>COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.. 
+PF04136 Sec34-like family <br>Pfam-B_16464 (release 7.3);. Sec34 and Sec35 form a sub-complex, in a seven protein complex that  includes Dor1 (Pfam:PF04124).  This complex is thought to be  important for tether vesicles to the Golgi  .. 
+PF02889 Sec63 Brl domain<br>This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons  .. 
+PF04048 Sec8 exocyst complex component specific domain<br>Pfam-B_9576 (release 7.3);. 
+PF00856 SET domain<br>SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases)  .  A subset of SET domains have been called PR domains.  These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction  .  The SET domain consists of two regions known as SET-N and SET-C.  SET-C forms an unusual and conserved knot-like structure of probably functional importance.  Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure  .. 
+PF03749 Sugar fermentation stimulation protein<br>This family contains Sugar fermentation stimulation proteins. Which is probably a regulatory factor involved in maltose metabolism. SfsA has been shown to bind DNA   and it contains a helix-turn-helix motif that probably binds DNA at its C-terminus.. 
+PF05002 SGS domain <br>This domain was thought to be unique to the SGT1-like proteins  , but is also found in calcyclin binding proteins.. 
+PF03983 SLA1 homology domain 1, SHD1 <br>Pfam-B_ (release 7.2). NPFXD peptides specifically interact with the SHD1 domain. NPFXD is a clathrin-facilitated endocytic targeting signal. NPFXD was originally discovered in the cytoplasmic  domain of the furin-like protease Kex2p  . Sla1 is thought to function as an endocytic adaptor  .  . 
+PF04925 SHQ1 protein<br>Pfam-B_11411 (release 7.6). S. cerevisiae SHQ1 protein is required for SnoRNAs of the box H/ACA Quantitative accumulation (unpublished).. 
+PF01549 DUF18;ShTK; <br>Pfam-B_662 (release 4.0). This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges.  The domain is found in the potassium channel inhibitor ShK in sea anemone   .. 
+PF04542 sigma70_r2; <br>Region 2 of sigma-70 is the most conserved region of the entire protein.  All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant.  The core binding helix, interacts with the  clamp domain of the largest polymerase subunit, beta prime [1,2]. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation [1,2]. . 
+PF04545 sigma70_r4;<br>Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif  . Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.. 
+PF03145 Seven in absentia protein family<br>Pfam-B_1854 (release 6.5). The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non- neuronal cell type. The Sina protein contains an N-terminal RING finger domain Pfam:PF00097. Through this domain, Sina binds E2 ubiquitin-conjugating enzymes (UbcD1) Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination, while PHYL down-regulates the activity of TTK88. In turn, the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase, a process essential for R7 determination. It is thought that thus Sina targets TTK88 for degradation, therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue Siah-1   also binds E2 enzymes (UbcH5) and through a series of physical interactions, targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53, itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation [2,3]. Sina proteins, therefore, physically interact with a variety of proteins. The N-terminal RING finger domain that binds ubiquitin conjugating enzymes is described in Pfam:PF00097, and does not form part of the alignment for this family. The remainder C-terminal part is involved in interactions with other proteins, and is included in this alignment. In addition to the Drosophila protein and mammalian homologues, whose similarity was noted previously, this family also includes putative homologues from Caenorhabditis elegans, Arabidopsis thaliana.. 
+PF04938 Survival motor neuron (SMN) interacting protein 1 (SIP1)<br>Pfam-B_5071 (release 7.6). Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans .. 
+PF03530 Calcium-activated SK potassium channel<br>
+PF02437 SKI/SNO/DAC family<br>Pfam-B_2013 (release 5.4). This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation  . Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].. 
+PF01466 Skp1 family, dimerisation domain<br>
+PF03931 Skp1 family, tetramerisation domain<br>
+PF00395 S-layer homology domain<br>
+PF01423 Sm; <br>The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins  . Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.. 
+PF02463 RecF/RecN/SMC N terminal domain<br>This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle.  The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics  .\.  This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.. 
+PF04158 Sof1-like domain <br>Pfam-B_9404 (release 7.3);. Sof1 is essential for cell growth and is a component of  the nucleolar rRNA processing machinery  . . 
+PF01033 Somatomedin B domain<br>
+PF03700 Sorting nexin, N-terminal domain <br>Pfam-B_29150 (release 7.0) . These proteins bins to the cytoplasmic domain of plasma membrane receptors. and are involved in endocytic protein trafficking.  The N-terminal domain appears to be specific to sorting nexins 1 and 2.. 
+PF04130 Spc97 / Spc98 family<br>Pfam-B_3531 (release 7.3). The spindle pole body (SPB) functions as the microtubule-organising centre in yeast. Members of this family are spindle pole body (SBP) components such as Spc97 and Spc98 that form a complex with gamma-tubulin. This family of proteins includes the grip motif 1 and grip moti 2  . Members of this family all form components of the gamma-tubulin complex, GCP  .. 
+PF04435 DUF545; <br>Domain of unknown function (DUF545)  . Pfam-B_429 (release 7.5). Family of uncharacterised C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.. 
+PF04014 SpoVT_AbrB;<br>Antidote-toxin recognition MazE. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation  , and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules  . MazF toxin functions as an mRNA interferase, cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest  .. 
+PF00622 SPRY domain<br>Alignment kindly provided by SMART. SPRY Domain is named from SPla and the RYanodine Receptor.  Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.. 
+PF03105 SPX domain<br>Pfam-B_502 (release 6.5). We have named this region the SPX domain after (SYG1, Pho81 and XPR1). This 180 residue length domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G- protein beta subunit and inhibits transduction of the mating pheromone signal  . This finding suggests that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 Swiss:P17442 from Saccharomyces cerevisiae and NUC-2 Swiss:Q01317 from Neurospora crassa, are also members of this family [see 4,5].  The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2   NUC-2 contains several ankyrin repeats Pfam:PF00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine leukaemia viruses (MLV)  .  The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae [1,2]. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor  .. 
+PF03125 C. elegans Sre G protein-coupled chemoreceptor<br>Pfam-B_352 (release 6.5). Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognised groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra Pfam:PF02117 and Srb Pfam:PF02175 comprise the Sra group. All of the above receptors are thought to be G protein-coupled seven transmembrane domain proteins [1,2]. The existence of several different chemosensory receptors underlies the fact that in spite of having only 20-30 chemosensory neurones, C. elegans detects hundreds of different chemicals, with the ability to discern individual chemicals among combinations  .. 
+PF04086 Signal recognition particle, alpha subunit, N-terminal<br>Pfam-B_7342 (release 7.3);. SRP is a complex of six distinct polypeptides and a 7S  RNA that is essential for transferring nascent polypeptide  chains that are destined for export from the cell to the  translocation apparatus of the endoplasmic reticulum (ER)  membrane  . SRP binds hydrophobic signal sequences as  they emerge from the ribosome, and arrests translation.. 
+PF00448 SRP54-type protein, GTPase domain<br>This family includes relatives of the G-domain of the SRP54 family of proteins.. 
+PF02881 SRP54-type protein, helical bundle domain<br>
+PF02978 Signal peptide binding domain<br>
+PF00436 Single-strand binding protein family<br>This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.. 
+PF04503 Single-stranded DNA binding protein, SSDP<br>Pfam-B_2031 (release 7.5). This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.. 
+PF05030 SSXT protein (N-terminal region)<br>Pfam-B_4900 (release 7.6). The SSXT or SS18 protein is involved in synovial sarcoma in humans.  A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes  at Xp11, SSX1 or SSX2  .. 
+PF01852 START domain<br>Alignment kindly provided by SMART. 
+PF01740 SpoIIAA; <br>The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function  .. 
+PF03015 Male sterility protein<br>Pfam-B_1115 (release 6.4). This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila.  A sequence-related jojoba acyl CoA reductase is also included.. 
+PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase <br>Pfam-B_1713 (release 5.4). This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor.  The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development  .  In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally  . A related enzyme is also found in plants is Swiss:Q38944 (DET2) a steroid reductase from Arabidopsis.  Mutations in this enzyme cause defects in light-regulated development  .. 
+PF02910 succ_DH_flav_C;<br>Fumarate reductase flavoprotein C-term. This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.. 
+PF00884 Sulfatase<br>Pfam-B_784 (release 3.0) & Pfam-B_7393 (Release 8.0). 
+PF00685 Sulfotransfer; <br>Sulfotransferase domain. Pfam-B_87 (release 2.1) & Pfam-B_1885 (Release 7.5). 
+PF03567 Sulfotransfer2; <br>Sulfotransferase family. Pfam-B_3050(7.0),Pfam-B_5394(7.7),Pfam-B_7836(10.0),Pfam-B_5040(7.5). This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST).  Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development  .  Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate  .. 
+PF04935 Surfeit locus protein 6<br>Pfam-B_5497 (release 7.6). The surfeit locus protein SURF-6 is shown to be a component of the  nucleolar matrix and has a strong binding capacity for nucleic acids  .. 
+PF01805 Surp module<br>This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding  .. 
+PF02201 SWIB/MDM2 domain<br>This family includes the SWIB domain and the MDM2 domain  . The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the  p53 binding domain of MDM2  .. 
+PF04434 SWIM zinc finger<br>This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organised into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (Pfam:PF00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts  .. 
+PF04433 SWIRM domain<br>This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins.  It contains a helix-turn helix motif and binds to DNA  .. 
+PF00804 Syntaxin<br>Pfam-B_1158 (release 2.1). Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A (Swiss:O35526) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role. The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors  .. 
+PF00907 T-box<br>Pfam-B_363 (release 3.0). The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations  .. 
+PF04719 hTAFII28-like protein conserved region<br>Pfam-B_4085 (release 7.5). The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex.  The conserved region is found at the C-terminal of most member proteins.  The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits.  The conserved region contains four alpha helices and three loops arranged as in histone H3 [1,2].. 
+PF04177 TAP42-like family<br>Pfam-B_5735 (release 7.3);. The TOR signalling pathway activates a cell-growth program in response to nutrients  . TIP41 (Pfam:PF04176) interacts with TAP42 and negatively regulates the TOR signaling pathway  .. 
+PF03943 TAP C-terminal domain<br>The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling  . The structure of the C-terminal domain is composed of four helices  . The structure is related to the UBA domain.. 
+PF03134 TB2/DP1, HVA22 family<br>Pfam-B_837 (release 6.5). This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein  (e.g. Swiss:Q00765), which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein (e.g. Swiss:Q07764), which is thought to be a regulatory protein.. 
+PF00352 Transcription factor TFIID (or TATA-binding protein, TBP)<br>
+PF03148 Tektin family<br>Pfam-B_3069 (release 6.5). Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organised as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are  predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components  .. 
+PF01397 Terpene synthase, N-terminal domain<br>Pfam-B_728 (release 3.0). It has been suggested that this gene family be designated tps (for terpene synthase)  .  It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.. 
+PF00440 tetR; <br>Bacterial regulatory proteins, tetR family. 
+PF03850 Transcription factor Tfb4<br>This family appears to be distantly related to the VWA domain.. 
+PF02269 TFIID-18; <br>Transcription initiation factor IID, 18kD subunit. Pfam-B_3681 (release 5.2). This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold  . 
+PF03847 TFIID_A; <br>Transcription initiation factor TFIID subunit A. 
+PF04494 TFIID_WDA; <br>WD40 associated region in TFIID subunit. Pfam-B_9152 (release 7.5). This region, possibly a domain is found in subunits of transcription factor TFIID.  The function of this region is unknown.. 
+PF04253 Transferrin receptor-like dimerisation domain<br>This domain is involved in dimerisation of the transferrin receptor as shown in its crystal structure.. 
+PF02824 TGS domain<br>The TGS domain is named after ThrRS, GTPase, and SpoT  . Interestingly, TGS domain was detected also at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly  beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role  . . 
+PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain<br>Pfam-B_882 (release 2.1). 
+PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain<br>Pfam-B_882 (release 2.1). 
+PF00899 ThiF_family;<br>Pfam-B_59 (release 3.0). This family contains a repeated domain in ubiquitin activating enzyme E1 and members of the bacterial ThiF/MoeB/HesA family.. 
+PF02597 DUF170;<br>ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer Swiss:O32583. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS  . MoaD, Swiss:P30748 a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end.. 
+PF01833 IPT/TIG domain<br>This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognise a significant number of members.. 
+PF04280 Tim44-like domain<br>TIGRFAMs (release 2.0);. Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane  .  Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region  .  This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast.  This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane  .. 
+PF04176 TIP41-like family <br>Pfam-B_12821 (release 7.3);. The TOR signalling pathway activates a cell-growth program in response to nutrients  . TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway  .. 
+PF01582 TIR domain<br>Pfam-B_571 (release 4.1). The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (Swiss:Q99836) and TOLLIP (Toll interacting protein, Swiss:Q9H0E2). In turn, these associate with various kinases to set off signalling cascades  .. 
+PF03920 TLE_N-terminal; <br>Groucho/TLE N-terminal Q-rich domain. The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerisation.. 
+PF05154 TM2 domain<br>This family is composed of a pair of transmembrane alpha helices connected by a short linker.  The function of this domain is unknown, however it occurs in a wide range or protein contexts.. 
+PF03348 TMS_TDE; <br>Serine incorporator (Serinc). Pfam-B_3473 (release 6.5). This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid  .  Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis  .. 
+PF03459 TOBE domain<br>The TOBE domain   (Transport-associated OB) always occurs  as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately  after the ATPase domain.. 
+PF04265 Thiamin pyrophosphokinase, vitamin B1 binding domain<br>TIGRFAMs (release 2.0);. Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis  .. 
+PF04263 Thiamin pyrophosphokinase, catalytic domain<br>TIGRFAMs (release 2.0);. Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis  .. 
+PF00515 TPR;<br>Tetratricopeptide repeat. Alignment kindly provided by SMART. 
+PF01938 DUF90;<br>
+PF00486 trans_reg_C; <br>Transcriptional regulatory protein, C terminal. Pfam-B_94 (release 1.0). 
+PF02458 Transferase family<br>Pfam-B_1540 (release 5.4). This family includes a number of transferase enzymes. These include anthranilate N-hydroxycinnamoyl/benzoyltransferase that catalyses the first committed reaction of phytoalexin biosynthesis  . Deacetylvindoline 4-O-acetyltransferase EC:2.3.1.107 catalyses the last step in vindoline biosynthesis is also a member of this family  . The motif HXXXD is probably part of the active site. The family also includes trichothecene 3-O-acetyltransferase.. 
+PF01336 Aspartyl_tRNA_N; tRNA_anti;<br>OB-fold nucleic acid binding domain. This family contains OB-fold domains that bind to nucleic acids  . The family includes the anti-codon binding domain of lysyl,  aspartyl, and asparaginyl -tRNA synthetases (See Pfam:PF00152). Aminoacyl-tRNA synthetases catalyse the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a heterotrimeric complex, that contains a subunit in this family [2,3]. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.. 
+PF01841 Transglutaminase-like superfamily<br>This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase, the human blood clotting factor XIIIa'  . On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase  , it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.  . 
+PF00927 1005; Transglutamin_C; <br>Transglutaminase family, C-terminal ig like domain. Pfam-B_1005 (release 3.0). 
+PF02779 transketolaseD2; transket_pyr; <br>Transketolase, pyrimidine binding domain. This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.. 
+PF02780 transketolaseD3; transketolase_C;<br>Transketolase, C-terminal domain. The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site  .. 
+PF00335 transmembrane4; <br>
+PF00905 Penicillin binding protein transpeptidase domain<br>The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.. 
+PF01609 Transposase_11;<br>Transposase DDE domain. Pfam-B_1013 (release 4.1). Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction  . This family contains transposases for  IS4 Swiss:P03835  ,  IS421 Swiss:P11901  , IS5377 Swiss:Q45620, IS427  , IS402  , IS1355 Swiss:O69604, IS5, which was original isolated in bacteriophage lambda  .. 
+PF02371 Transposase_19; <br>Transposase IS116/IS110/IS902 family. Pfam-B_280 (release 5.2). Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with Pfam:PF01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.. 
+PF01526 Transposase_7;<br>Tn3 transposase DDE domain. Pfam-B_885 (release 4.0). This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli.  The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases  .. 
+PF01548 Transposase_9;<br>Pfam-B_646 (release 4.0). Transposase proteins are necessary for efficient DNA transposition.  This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and members of the IS111A/IS1328/IS1533 family of transposases.. 
+PF00579 tRNA synthetases class I (W and Y)<br>MRC-LMB Genome group. 
+PF01409 tRNA synthetases class II core domain (F)<br>Other tRNA synthetase sub-families are too dissimilar to be included.  This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.. 
+PF01588 Putative tRNA binding domain<br>Pfam-B_482 (release 4.1). This domain is found in prokaryotic methionyl-tRNA synthetases,  prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding  protein (G4p1 or p42, ARC1)  , human tyrosyl-tRNA synthetase  , and endothelial-monocyte activating polypeptide II.  G4p1 binds specifically to tRNA form a complex with methionyl-tRNA  synthetases  . In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme  . This domain may perform a common function in tRNA aminoacylation  .. 
+PF03250 Tropomodulin<br>Pfam-B_3359 (release 6.5). Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments  . Limited proteolysis shows this protein is composed of two domains  . The amino terminal domain contains the tropomyosin binding function  .. 
+PF00992 Troponin<br>Pfam-B_62 (release 3.0). Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I.  Troponin I binds to actin and troponin T binds to tropomyosin.. 
+PF00234 tryp_alpha_amyl; <br>Protease inhibitor/seed storage/LTP family. This family is composed of trypsin-alpha amylase inhibitors, seed  storage proteins and lipid transfer proteins from plants.. 
+PF00089 trypsin;<br>
+PF02210 TSPN; TSP_N;<br>Pfam-B_4211 (release 12.0) . This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.. 
+PF03133 Tubulin-tyrosine ligase family<br>Pfam-B_682 (release 6.5). Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL)  . The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness  . On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis  .  Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent  dioxygenase domain  .. 
+PF01167 Tub family<br>
+PF03953 tubulin_C; <br>Tubulin C-terminal domain. This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).. 
+PF00567 Tudor domain<br>Alignment kindly provided by SMART. 
+PF04906 Tweety<br>Pfam-B_5713 (release 7.6). The tweety (tty) gene has not been characterised at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in  .. 
+PF04564 U-box domain<br>Pfam-B_2801 (release 7.5). This domain is related to the Ring finger Pfam:PF00097 but lacks the zinc binding residues  .. 
+PF00627 UBA/TS-N domain<br>This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle  . This domain is found at the N terminus of EF-TS hence the name TS-N.  The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU  . The domain has been found in non EF-TS proteins such as alpha-NAC Swiss:P70670 and MJ0280 Swiss:Q57728  .. 
+PF01040 CytC_assmbly_fac; COX10_ctaB_cyoE;<br>UbiA prenyltransferase family. Pfam-B_1357 (release 3.0). 
+PF00240 Ubiquitin family<br>This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites  .. 
+PF00789 UBX domain<br>SMART, Mistry J, Wood V. Alignment kindly provided by SMART. This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module  .. 
+PF00443 UCH-2;<br>Ubiquitin carboxyl-terminal hydrolase. 
+PF03456 uDENN domain<br>This region is always found associated with Pfam:PF02141. It is predicted to form an all beta domain  .. 
+PF03167 Uracil DNA glycosylase superfamily<br>
+PF02809 Ubiquitin interaction motif<br>This motif is called the ubiquitin interaction motif. One of the proteins containing this motif is a receptor for poly-ubiquitination chains for the proteasome  . This motif has a pattern of conservation characteristic of an alpha helix.. 
+PF01027 UPF0005;<br>Inhibitor of apoptosis-promoting Bax1. Pfam-B_1376 (release 3.0) & Pfam-B_5704 (release 7.5). Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localised to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localise predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress  . BI-1 appears to exert its effect through an interaction with calmodulin  . The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner  .. 
+PF03684 Uncharacterised protein family (UPF0179)<br>The function of this family is unknown, however the proteins contain two cysteine clusters that may be iron sulphur redox centres.. 
+PF03699 Uncharacterised protein family (UPF0182)<br>This family contains uncharacterised integral membrane proteins.. 
+PF03676 Uncharacterised protein family (UPF0183)<br>This family of proteins includes Lin-10 from C. elegans. . 
+PF03671 UPF0185; <br>Ubiquitin fold modifier 1 protein. This is a family of short ubiquitin-like proteins, that is like neither type-1 or type-2. It is a ubiquitin-fold modifier 1 (Ufm1) that is synthesised in a precursor form of 85 amino-acid residues. In humans the enzyme for Ufm1 is Uba5 and the conjugating enzyme is Ufc1. Prior to activation by Uba5 the extra two amino acids at the C-terminal region of the human pro-Ufm1 protein are removed to expose Gly whose residue is necessary for conjugation to target molecule(s). The mature Ufm1 is conjugated to yet unidentified endogenous proteins, . While Ubiquitin and many Ubls possess the conserved C-terminal di-glycine that is adenylated by each specific E1 or E1-like enzyme, respectively, in an ATP-dependent manner, Ufm1(1-83) possesses a single glycine at its C-terminus, which is followed by a Ser-Cys dipeptide in the precursor form of Ufm1. The C-terminally processed Ufm1(1-83) is specifically activated by Uba5, an E1-like enzyme, and then transferred to its cognate Ufc1, an E2-like enzyme  .. 
+PF00179 Ubiquitin-conjugating enzyme<br>Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].. 
+PF02814 UreE;<br>UreE urease accessory protein, N-terminal domain. Pfam-B_6279 (release 6.1). UreE is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid.. 
+PF04192 Utp21 specific WD40 associated putative domain <br>Pfam-B_16350 (release 7.3);. Utp21 is a subunit of U3 snoRNP, which is essential for  synthesis of 18S rRNA.. 
+PF02151 UvrB/uvrC motif<br>
+PF05008 Vesicle transport v-SNARE protein N-terminus<br>Pfam-B_5492 (release 7.6). V-SNARE proteins are required for protein traffic between eukaryotic organelles. The v-SNAREs on transport vesicles interact with t-SNAREs on target membranes in order to facilitate this  .  This domain is the N-terminal half of the V-Snare proteins.. 
+PF00790 VHS domain<br>Alignment kindly provided by SMART. Domain present in VPS-27, Hrs and STAM.. 
+PF00654 voltage_CLC; <br>Voltage gated chloride channel. wublastp P37020/1-588. This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 (Swiss:P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney  . These proteins contain two Pfam:PF00571 domains.. 
+PF04840 Vps16, C-terminal region<br>Pfam-B_6003 (release 7.6). This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast  . The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole.  It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport  .  The role of VPS16 in this complex is not known.. 
+PF04841 Vps16, N-terminal region<br>Pfam-B_6003 (release 7.6). This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast  . The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole.  It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport  .  The role of VPS16 in this complex is not known.. 
+PF03635 Vacuolar protein sorting-associated protein 35 <br>Pfam-B_3569 (release 7.0). Vacuolar protein sorting-associated protein (Vps) 35 is one of around 50 proteins involved in protein trafficking.  In particular, Vps35  assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps26 and Vps29.  Vps35 contains a central region of weaker sequence similarity, thought to indicate the presence of at least three domains .. 
+PF04129 Vps52 / Sac2 family <br>Pfam-B_10164 (release 7.3);. Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events  .. 
+PF04100 Vps53-like, N-terminal <br>Pfam-B_5601 (release 7.3);. Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events  .. 
+PF02204 Vacuolar sorting protein 9 (VPS9) domain<br>Alignment kindly provided by SMART. This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind  .. 
+PF03302 Giardia variant-specific surface protein<br>Pfam-B_4536 (release 6.5). 
+PF00092 vwa; <br>von Willebrand factor type A domain. 
+PF00094 vwd; <br>von Willebrand factor type D domain. Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.. 
+PF00095 wap; <br>WAP-type (Whey Acidic Protein) 'four-disulfide core'. Swissprot_feature_table. 
+PF00400 G-beta; <br>WD domain, G-beta repeat. Pfam-B_2 (release 1.0). 
+PF00568 WH1 domain<br>Alignment kindly provided by SMART. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha  and mGluR5 bind a protein called homer, which is a WH1 domain homologue   . A subset of WH1 domains has been termed a "EVH1" domain   and  appear to bind a polyproline motif.. 
+PF02205 WH2 motif<br>Alignment kindly provided by SMART. The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP Swiss:P42768 and Scar1 (mammalian homologue) to be the region that interacts with actin.. 
+PF02467 Transcription factor WhiB<br>Pfam-B_2249 (release 5.4). WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.. 
+PF02019 WIF domain<br>The WIF domain is found in the RYK tyrosine kinase receptors Swiss:P34925 and WIF the Wnt-inhibitory- factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge.  This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt  . The WIF domain is a member of the immunoglobulin superfamily, and it comprises nine beta-strands and two alpha-helices, with two of the beta-strands (6 and 9) interrupted by four and six residues of irregular secondary structure, respectively. Considering that the activity of Wnts depends on the presence of a palmitoylated cysteine residue in their amino-terminal polypeptide segment, Wnt proteins are lipid-modified and can act as stem cell growth factors, it is likely that the WIF domain recognises and binds to Wnts that have been activated by palmitoylation and that the recognition of palmitoylated Wnts by WIF-1 is effected by its WIF domain rather than by its EGF domains. A strong binding affinity for palmitoylated cysteine residues would further explain the remarkably high affinity of human WIF-1 not only for mammalian Wnts, but also for Wnts from Xenopus and Drosophila  .. 
+PF03106 WRKY DNA -binding domain<br>Pfam-B_85 (release 6.5). 
+PF02206 Domain of unknown function<br>Alignment kindly provided by SMART. 
+PF00397 WW_rsp5_WWP; <br>The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.. 
+PF02825 WWE domain<br>The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems  .. 
+PF02706 wzz; <br>Chain length determinant protein. Pfam-B_1977 (release 5.5). This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps  . This region is also found as part of bacterial tyrosine kinases such as Swiss:P38134.. 
+PF03254 Xyloglucan fucosyltransferase<br>Pfam-B_3419 (release 6.5). Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residue  .. 
+PF05181 XPA;<br>XPA protein C-terminus. 
+PF01286 XPA; <br>XPA protein N-terminal. 
+PF00102 Protein-tyrosine phosphatase<br>Swissprot_feature_table. 
+PF04893 DUF649; <br>Pfam-B_5598 (release 7.6). The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases  .. 
+PF03226 Yippee;<br>Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. Pfam-B_2930 (release 6.5). This family includes both Yippee-type proteins and Mis18 kinetochore proteins.\. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus  .. 
+PF02757 YLP motif<br>The YLP motif is found in several drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues and its presence in Swiss:Q15303 may suggest it could be a substrate for tyrosine kinases.. 
+PF04146 YT521-B; <br>Pfam-B_1386 (release 7.3). A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells  .  It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing.  The rat protein Swiss:Q9QY02 YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner  . The YTH domain has been identified as part of the PUA superfamily  .. 
+PF00643 B-box zinc finger<br>
+PF02892 BED zinc finger<br>
+PF01530 Zinc finger, C2HC type<br>This is a DNA binding zinc finger domain.. 
+PF00097 Zinc finger, C3HC4 type (RING finger)<br>Swissprot_feature_table. The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid  . Many proteins containing a RING finger play a key role in the ubiquitination pathway  .. 
+PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar)<br>
+PF00098 Zinc knuckle<br>Overington and HMM_iterative_training. The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag  proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.. 
+PF02008 CXXC zinc finger domain<br>This domain contains eight conserved cysteine residues that bind to two zinc ions.  The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterised by two repeats  , and shows a peculiar internal duplication in which the second unit is inserted into the first one  . Each of these units is  characterised by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been  identified by NMR  . In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess  a mono-CXXC domain that is present in distinct chromatin proteins   . Structural comparisons show that the mono-CXXC is homologous  to the structural-zinc binding domain of medium chain  dehydrogenases  .. 
+PF01529 DHHC palmitoyltransferase<br>Pfam-B_945 (release 4.0). This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.. 
+PF04438 HIT zinc finger<br>This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein Swiss:P46973. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) Swiss:Q15649 that specifically interact with the ligand binding domain of the thyroid receptor.. 
+PF02891 MIZ/SP-RING zinc finger<br>This domain has SUMO (small ubiquitin-like modifier) ligase activity and is involved in DNA repair and chromosome organisation   .. 
+PF01753 MYND finger<br>
+PF05020 NPL4 family, putative zinc binding region<br>Pfam-B_13681 (release 7.6). 
+PF04810 Sec23/Sec24 zinc finger<br>COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.. 
+PF02148 Zn-finger in ubiquitin-hydrolases and other protein<br>
+PF04704 Zfx / Zfy transcription activation region<br>Zfx and Zfy are transcription factors implicated in mammalian sex  determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger  (Pfam:PF00096).  This region has been shown to activate transcription when fused to a GAL4 DNA binding domain  .. 
+PF02535 ZIP Zinc transporter<br>Pfam-B_1189 (release 5.4) & Pfam-B_1903 (Release 7.5). The ZIP family consists of zinc transport proteins and many putative metal transporters.  The main contribution to this family is from  the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant  .  Also found within this family are  C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.. 
+PF00246 Zn_carbOpept; <br>Zinc carboxypeptidase. Prosite & Pfam-B_4832 (Release 7.5). 
+PF00100 zona_pellucida; <br>Zona pellucida-like domain. Swissprot_feature_table. 
+PF01262 AlaDh_PNT; <br>Alanine dehydrogenase/PNT, C-terminal domain. Pfam-B_4166 (release 6.6). This family now also contains the lysine 2-oxoglutarate reductases. . 
+PF05222 Alanine dehydrogenase/PNT, N-terminal domain<br>This family now also contains the lysine 2-oxoglutarate reductases. . 
+PF05218 Protein of unknown function (DUF713)<br>Moxon SJ, Pollington J. Pfam-B_6651 (release 7.7). This family contains several proteins of unknown function from C.elegans. The GO annotation suggests that this protein is involved in nematode development and has a positive regulation on growth rate.. 
+PF05210 Sprouty protein (Spry)<br>Pfam-B_6527 (release 7.7). This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases  . The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice  .. 
+PF05216 UNC-50 family<br>Pfam-B_6607 (release 7.7). Gmh1p (Swiss:P36125) from S. cerevisiae is located in the Golgi membrane and interacts with ARF exchange factors  .. 
+PF00702 haloacid dehalogenase-like hydrolase<br>Pfam-B_566 (release 2.1). This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain  . Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria  .. 
+PF04227 Indigoidine synthase A like protein<br>Indigoidine is a blue pigment synthesised by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown  . The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.. 
+PF04613 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD  <br>UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyses an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]  . Members of this family also contain a hexapeptide repeat (Pfam:PF00132).  This family constitutes the non-repeating region of LPXD proteins.. 
+PF00244 14-3-3 protein<br>
+PF02826 2-Hacid_DH_C; <br>D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain. This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389.. 
+PF02834 2_5_ligase; 2_5_RNA_ligase;<br>LigT like Phosphoesterase. Members of this family are bacterial and archaeal RNA ligases that are able to ligate tRNA half molecules containing 2',3'-cyclic phosphate and 5' hydroxyl termini to products containing the 2',5' phosphodiester linkage. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family. The structure of a related protein is known  . They belong to the 2H phosphoesterase superfamily  . They share a common active site, characterised by two conserved histidines, with vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.. 
+PF03475 3-alpha domain<br>Aravind L, Anantharaman V. This small triple helical domain has been predicted to assume a topology similar to helix-turn-helix domains. These domains are found at the C-terminus of proteins related to Swiss:P32157.. 
+PF01612 3_5_exonuclease; 3_5_exonuc;<br>Pfam-B_659 (release 4.1). This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D).  Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction [4,5].  The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein  . RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.. 
+PF00803 3A/RNA2 movement protein family<br>Pfam-B_1054 (release 2.1) & Pfam-B_6332 (release 7.5). This family includes movement proteins from various viruses. The 3A protein is found in bromoviruses and Cucumoviruses. The genome of these viruses contain 3 RNA segments.  The third segment (RNA 3) contains two proteins, the coat protein and the 3A protein. The function of the 3A protein is uncertain but has been shown to be involved in cell-to- cell movement of the virus  . The family also includes movement proteins from Dianthoviruses.. 
+PF02829 3H domain<br>This domain is predicted to be a small molecule binding domain, based on its occurrence with other domains  . The domain is named after its three conserved histidine residues.. 
+PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain<br>Pfam-B_743 (release 2.1). This family also includes lambda crystallin. Some proteins include two copies of this domain.. 
+PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain<br>Pfam-B_743 (release 2.1). This family also includes lambda crystallin.. 
+PF02446 4A_glucanotrans; 4a_glucanotrans; <br>4-alpha-glucanotransferase. Pfam-B_1924 (release 5.4). These enzymes EC:2.4.1.25 transfer a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan  .. 
+PF01812 5-formyltetrahydrofolate cyclo-ligase family<br>Pfam-B_1555 (release 4.2). 5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase EC:6.3.3.2 catalyses the interchange of 5-formyltetrahydrofolate  (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+  . 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin  .. 
+PF02739 5'-3' exonuclease, N-terminal resolvase-like domain<br>Pfam-B_716 (release 3.0). 
+PF01367 5_3_exonuclease; <br>5'-3' exonuclease, C-terminal SAM fold. Pfam-B_716 (release 3.0). 
+PF03491 Serotonin (5-HT) neurotransmitter transporter, N-terminus<br>
+PF02096 60Kd inner membrane protein<br>
+PF00428 60s_ribosomal;<br>60s Acidic ribosomal protein. Pfam-B_151 (release 1.0). This family includes archaebacterial L12, eukaryotic P0, P1 and P2.. 
+PF01591 6-phosphofructo-2-kinase<br>Pfam-B_717 (release 4.1). This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis  . This enzyme contains a P-loop motif.. 
+PF00393 6-phosphogluconate dehydrogenase, C-terminal domain<br>This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase.\.  The domain contains two structural repeats of 5 helices each.. 
+PF02495 7kD viral coat protein<br>Pfam-B_2886 (release 5.4). This family consists of a 7kD coat protein from carlavirus  and potexvirus  .. 
+PF02294 7kD DNA-binding domain<br>Pfam-B_8148 (release 5.2). This family contains members of the hyper-thermophilic archaebacterium  7kD DNA-binding/endoribonuclease P2 family. There are five 7kD DNA-binding proteins, 7a-7e, found as monomers in the cell. Protein 7e shows the  tightest DNA-binding ability.. 
+PF00001 7 transmembrane receptor (rhodopsin family)<br>This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins  .. 
+PF00002 7 transmembrane receptor (Secretin family)<br>This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognised. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 (Swiss:P48960); calcium-independent receptors for latrotoxin (such as Swiss:O94910), and brain-specific angiogenesis inhibitors (such as Swiss:O14514) amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins (e.g. Swiss:P83119). Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling  .. 
+PF02949 7tm Odorant receptor<br>Pfam-B_436 (release 6.4). This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.. 
+PF00207 Alpha-2-macroglobulin family<br>This family includes the C-terminal region of the alpha-2-macroglobulin family.. 
+PF01835 MG2 domain<br>This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin  .. 
+PF01356 Alpha amylase inhibitor<br>
+PF02137 Adenosine-deaminase (editase) domain<br>Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc  .. 
+PF00324 aa_permeases; <br>
+PF03306 Alpha-acetolactate decarboxylase<br>Pfam-B_3661 (release 6.5). 
+PF04611 Mating type protein A alpha Y mating type dependent binding region <br>This region is important for the mating type dependent binding of Y protein to the A alpha Z protein of another mating type in Schizophyllum commune  .. 
+PF03417 Peptidase_C45; <br>Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase. 
+PF02496 ABA/WDS induced protein<br>Pfam-B_2496 (release 5.4). This is a family of plant proteins induced by water deficit stress (WDS)  , or abscisic acid (ABA) stress and ripening  . . 
+PF00950 ABC 3 transport family<br>Pfam-B_1591 (release 2.1). 
+PF01061 ABC-2 type transporter<br>Pfam-B_865 (release 3.0) & Pfam-B_31 (release 15.0). 
+PF00664 ABC transporter transmembrane region<br>Pfam-B_2 (release 2.1). This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (Pfam:PF00005) have two such regions.. 
+PF00005 ABC transporter<br>ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes.  ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664.  These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.. 
+PF00561 abhydrolase; <br>alpha/beta hydrolase fold. MRC-LMB Genome group. This catalytic domain is found in a very wide range of enzymes.. 
+PF03806 AbgT putative transporter family<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02230 abhydrolase_2; <br>Phospholipase/Carboxylesterase. Pfam-B_1382 (release 5.2). This family consists of both phospholipases   and carboxylesterases with broad substrate specificity, and is structurally related to  alpha/beta hydrolases Pfam:PF00561  .. 
+PF02517 CAAX protease self-immunity<br>Pfam-B_1073 (release 5.4). Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases).  The family contains the Swiss:Q03530 CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding  . While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin.  Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity  .. 
+PF03992 Antibiotic biosynthesis monooxygenase<br>This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is  suggestive that the other proteins function as  multimers. There is also a conserved histidine which is likely to be an active site residue.. 
+PF00887 Acyl CoA binding protein<br>Pfam-B_864 (release 3.0). 
+PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit<br>Pfam-B_1935 (release 6.5). Acetyl co-enzyme A carboxylase carboxyltransferase is composed of an alpha and beta subunit.. 
+PF00871 Acetokinase family<br>Pfam-B_1595 (release 2.1). This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.. 
+PF02550 Acetyl-CoA_hydro; <br>Acetyl-CoA hydrolase/transferase N-terminal domain. This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA.. 
+PF00797 Acetyltransf2; <br>Pfam-B_575 (release 2.1). Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.. 
+PF00328 acid_phosphat; Acid_phosphat_A;<br>Histidine phosphatase superfamily (branch 2). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins.  The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase.  The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.. 
+PF03767 acid_phosphat_B;<br>HAD superfamily, subfamily IIIB (Acid phosphatase). Pfam-B_2784 (release 7.0). This family proteins includes acid phosphatases and a number of vegetative storage proteins. . 
+PF00330 aconitase; <br>Aconitase family (aconitate hydratase). 
+PF00694 Aconitase C-terminal domain<br>Pfam-B_224 (release 2.1). Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism  .. 
+PF01756 Acyl-CoA oxidase<br>Pfam-B_598 (release 4.2). This is a family of Acyl-CoA oxidases EC:1.3.3.6. Acyl-coA oxidase converts acyl-CoA into trans-2- enoyl-CoA  .. 
+PF00873 AcrB/AcrD/AcrF family<br>Pfam-B_578 (release 3.0). Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer  membrane channel TolC. The structure shows the AcrB forms a  homotrimer  .. 
+PF05058 ActA Protein<br>Pfam-B_5981 (release 7.7). The ActA family is found in Listeria and is associated with motility. ActA protein acts as a scaffold to assemble and activate host cell actin cytoskeletal factors at the bacterial surface, resulting in directional actin polymerisation and propulsion of the bacterium through the cytoplasm of the host cell [1,2]. . 
+PF00976 Corticotropin ACTH domain<br>Pfam-B_1057 (release 3.0). 
+PF00022 actin; <br>
+PF01643 Acyl-ACP thioesterase<br>Pfam-B_928 (release 4.1). This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via  hydrolysing an acyl group on a fatty acid  .. 
+PF02770 Acyl-CoA dehydrogenase, middle domain<br>Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold.. 
+PF02771 Acyl-CoA dehydrogenase, N-terminal domain<br>The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha  domain.. 
+PF02551 Acyl-CoA thioesterase<br>This family represents the thioesterase II domain.  Two copies of this domain are found in a number of acyl-CoA thioesterases.. 
+PF00698 Acyl_transf; <br>Acyl transferase domain. Pfam-B_250 (release 2.1). 
+PF02273 Acyl transferase<br>Pfam-B_5787 (release 5.2). This bacterial family of Acyl transferases (or myristoyl-acp-specific thioesterases) catalyse the first step in the bioluminescent fatty acid reductase system.. 
+PF00708 Acylphosphatase<br>Pfam-B_686 (release 2.1). 
+PF01553 Acyltransferase<br>Pfam-B_128 (release 4.0) & Pfam-B_5069 (Release 7.5). This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function  .  This family also includes tafazzin Swiss:Q16635, the Barth syndrome gene  .. 
+PF02805 Metal binding domain of Ada<br>The Escherichia coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue. This domain contains four conserved cysteines that form a zinc binding site [1,2]. One of these cysteines is a methyl group acceptor. The methylated domain can then specifically bind to the ada box on a DNA duplex  .. 
+PF01602 Adaptin N terminal region<br>Pfam-B_491 (release 4.0). This family consists of the N terminal region of various alpha,  beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles  . The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family ; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles  .. 
+PF03352 Methyladenine glycosylase<br>Pfam-B_3953 (release 6.5). The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA. . 
+PF02438 adeno_100; <br>Pfam-B_1583 (release 5.4). The late 100kD protein is a non-structural viral protein involved in the transport of hexon from the cytoplasm to the nucleus.. 
+PF03052 Adenoviral protein L1 52/55-kDa<br>Pfam-B_2151 (release 6.4). The adenoviral protein L1 52/55-kDa is expressed in both the early and late stages of infection which suggests that it could play multiple roles in the viral life cycle.  The L1 52/55 kDa protein interacts with the viral IVa2 protein and is required for DNA packaging   . L1 53/55-kDa is required to mediate stable association between the viral DNA and empty capsid  .. 
+PF02703 Early E1A protein<br>Pfam-B_1193 (release 5.5). This is a family of adenovirus early E1A proteins.  The E1A protein is  32 kDa it can however be cleaved to yield the 28 kDa protein.  The E1A protein is responsible for the transcriptional activation of the early genes with in the viral genome at the start of the infection process as  well as some cellular genes  .. 
+PF01691 Adenovirus E1B 19K protein / small t-antigen<br>Pfam-B_1569 (release 4.1). This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell  . It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen  . E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein  .  The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis  .. 
+PF01696 Adenovirus EB1 55K protein / large t-antigen<br>Pfam-B_1728 (release 4.1). This family consists of adenovirus E1B 55K protein or large t-antigen. E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site  .  This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein  .  The E1B region of adenovirus encodes two proteins E1B 55K the large t-antigen as found in this family and E1B 19K Pfam:PF01691 the small t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.  This family shows distant similarities to the pectate lyase superfamily.. 
+PF04623 Adenovirus E1B protein N-terminus<br>This family constitutes the amino termini of E1B 55 kDa (Pfam:PF01696). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site  . This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein  . The role of the N terminus in the function of E1B is not known.. 
+PF04834 Early E3 14.5 kDa protein<br>Pfam-B_4148 (release 7.6). The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm.  It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis.  It achieves this through the interaction with E3 10.4 kDa protein [1,2].. 
+PF03307 Adenovirus 15.3kD protein in E3 region<br>Pfam-B_3512 (release 6.5). 
+PF02440 Adenovirus E3 region protein CR1<br>Pfam-B_1854 (release 5.4). 
+PF02439 Adenovirus E3 region protein CR2<br>Pfam-B_1854 (release 5.4). Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host  . This region called CR2 (conserved region 1)   is found in Adenovirus type 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR2 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 50 amino acid region is unknown.. 
+PF03376 Adenovirus E3B protein<br>Pfam-B_3736 (release 6.6). 
+PF04528 Adenovirus early E4 34 kDa protein conserved region<br>Pfam-B_4904 (release 7.5). Conserved region found in the Adenovirus E4 34 kDa protein.. 
+PF00541 adeno_fiber; <br>Adenoviral fibre protein (knob domain). Specific  attachment of adenovirus is achieved through interactions  between host-cell receptors and the adenovirus fibre protein and is  mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.. 
+PF00608 adeno_fiber2; <br>Adenoviral fibre protein (repeat/shaft region). There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.. 
+PF04881 Adenovirus GP19K<br>Pfam-B_6142 (release 7.6). This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER).  The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes  .. 
+PF01065 Hexon, adenovirus major coat protein, N-terminal domain<br>Pfam-B_885 (release 3.0). Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX.  The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices  . The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.. 
+PF03678 Hexon, adenovirus major coat protein, C-terminal domain<br>Pfam-B_885 (release 3.0). Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX.  The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices  . The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.. 
+PF02456 Adenovirus IVa2 protein<br>Pfam-B_1982 (release 5.4). IVa2 protein can interact with the adenoviral packaging signal and that this interaction involves DNA sequences that have previously been demonstrated to be required for packaging  . During the course of lytic infection, the adenovirus major late promoter (MLP) is induced to high levels after replication of viral DNA has started. IVa2 is a transcriptional activator of the major late promoter  . . 
+PF01686 Adenovirus penton base protein<br>Pfam-B_1180 (release 4.1). This family consists of various adenovirus penton base proteins, from both the Mastadenoviradae having mammalian hosts and the Aviadenoviradae having avian hosts. The penton base is a major structural protein forming part of the penton which consists of a base and a fibre, the pentons hold a morphologically prominent position at the vertex capsomer in the adenovirus particle  . In mammalian adenovirus there is only one tail on each base where as in avian adenovirus there are two  .. 
+PF03955 Adenovirus hexon-associated protein (IX)<br>Hexon (PF01065) is the major coat protein from  adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together  by 12 copies of polypeptide IX.. 
+PF03910 Adenovirus minor core protein PV<br>
+PF01310 Adenovirus hexon associated protein, protein VIII<br>Pfam-B_1405 (release 3.0). See Pfam:PF01065. This family represents Hexon.. 
+PF02459 Adenoviral DNA terminal protein<br>Pfam-B_1602 (release 5.4). This protein is covalently attached to the terminii of replicating DNA in vivo  .. 
+PF03228 Adenoviral core protein VII<br>Pfam-B_3049 (release 6.5). The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.. 
+PF04439 Streptomycin adenylyltransferase<br>Also known as Aminoglycoside 6- adenylyltransferase (EC:2.7.7.-), this protein confers resistance to aminoglycoside antibiotics.. 
+PF01928 Adenylate_cyc_2; <br>These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate.  Six distinct non-homologous classes of AC have been identified.  The structure of three classes of adenylyl cyclases have been solved  .. 
+PF01295 Adenylate_cycla; <br>Adenylate cyclase, class-I. 
+PF00709 Adenylosuccinate synthetase<br>Pfam-B_690 (release 2.1). 
+PF00106 short chain dehydrogenase<br>This family contains a wide variety of dehydrogenases.. 
+PF04619 Dr-family adhesin<br>This family of adhesins bind to the Dr blood group antigen component of decay-accelerating factor.  This mediates adherence of uropathogenic Escherichia coli to the urinary tract.  This family contains both fimbriated and afimbriated adherence structures  .  This protein also confers the phenotype of mannose-resistant hemagglutination, which can be inhibited by chloramphenicol.  The N terminal portion of the protein is though to be responsible for chloramphenicol sensitivity  .. 
+PF03257 Mycoplasma adhesin P1<br>Pfam-B_4117 (release 6.5). This family corresponds to a short 100 residue region found in adhesins from Mycoplasmas.. 
+PF00406 adenylatekinase; <br>
+PF05191 Adenylate kinase, active site lid<br>Comparisons of adenylate kinases have revealed  a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly  structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely  structural function  .. 
+PF05221 S-adenosyl-L-homocysteine hydrolase<br>Pfam-B_157 (release 2.1). 
+PF00670 AdoHcyase; <br>S-adenosyl-L-homocysteine hydrolase, NAD binding domain. Pfam-B_157 (release 2.1). 
+PF03747 ADP-ribosyl_GH;<br>ADP-ribosylglycohydrolase. This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine  . The family also includes  dinitrogenase reductase activating glycohydrolase  . Most surprisingly the family also includes jellyfish crystallins  , these proteins appear to have lost the presumed active site residues.. 
+PF04587 ADP-specific Phosphofructokinase/Glucokinase conserved region<br>Pfam-B_4731 (release 7.5). In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilises two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase.  This conserved region is present at the C-terminal of both these proteins.  Interestingly this family contains sequences from higher eukaryotes. [1,2,3]. . 
+PF01117 Aerolysin toxin<br>This family represents the pore forming lobe of aerolysin.. 
+PF05110 AF-4 proto-oncoprotein<br>Pfam-B_6407 (release 7.7). This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation  . The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain.  Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila  .. 
+PF03969 AFG1-like ATPase<br>This family of proteins contains a P-loop motif and are predicted to be ATPases.. 
+PF01314 AFOR; <br>Aldehyde ferredoxin oxidoreductase, domains 2 & 3. Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible  oxidation of aldehydes to their corresponding carboxylic acids  with their accompanying reduction of the redox protein ferredoxin.  This family is composed of two structural domains that bind the  tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR  .. 
+PF02730 Aldehyde ferredoxin oxidoreductase, N-terminal domain<br>Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This domain interacts with the tungsten cofactor  .. 
+PF02420 Insect antifreeze protein repeat<br>This family of extracellular proteins is involved in stopping the formation of ice crystals at low temperatures. The proteins are composed of a 12 residue repeat that forms a structural repeat. The structure of the repeats is a beta helix  . Each repeat contains two cys residues that form a disulphide bridge.. 
+PF03756 AfsA_repeat; <br>A-factor biosynthesis hotdog domain. The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain  .. 
+PF04671 Erythrocyte membrane-associated giant protein antigen 332 <br>Pfam-B_4587 (release 7.5). To date many different Plasmodium antigens recognised by the hyperimmune system human sera have been cloned, sequenced and characterised.  The majority contain tandemly repeated amino acid sequences which make up a considerable portion of the protein sequence. It has been suggested that these repeat-containing antigens may provide an immunological 'smokescreen' to the parasite in order to evade the human immune system. This repeat is found exclusively in the Plasmodium falciparum Ag332 protein and occupies most of its length  .. 
+PF01453 Agglutinin; MMBL2; MMBL; Agglutinin;<br>D-mannose binding lectin. Prodom_2511 (release 99.1). These proteins include mannose-specific lectins from plants  as well as bacteriocins from bacteria  .. 
+PF05039 agouti; <br>Pfam-B_5381 (release 7.7). The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation    .. 
+PF04647 Accessory gene regulator B<br>Pfam-B_5200 (release 7.5). The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system.  AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing.  AgrB is a transmembrane protein  .. 
+PF04730 Agrobacterium VirD5 protein<br>Pfam-B_3261 (release 7.5). The virD operon in Agrobacterium encodes a site-specific endonuclease, and a number of other poorly characterised products. This family represents the VirD5 protein.. 
+PF00578 AhpC/TSA family<br>MRC-LMB Genome group. This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA). . 
+PF02626 DUF183; <br>Allophanate hydrolase subunit 2. This domain forms the second subunit of allophanate hydrolase. In yeast urea amidolyase (Swiss:P32528) this domain is found between Pfam:PF00289 and Pfam:PF00364.. 
+PF01808 AICARFT/IMPCHase bienzyme<br>Pfam-B_1613 (release 4.2). This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide  ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate  . This is catalysed by a pair of C-terminal deaminase fold domains in the protein  , where the active site is formed by the dimeric interface of two monomeric units  . The last  step is catalysed by the N-terminal IMP (Inosine monophosphate)  cyclohydrolase domain EC:3.5.4.10 (IMPCHase), cyclizing FAICAR  (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP  . . 
+PF04548 AIG1 family<br>Pfam-B_1846 (release 7.5). Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.. 
+PF00731 AIR carboxylase<br>Pfam-B_462 (release 2.1). Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.. 
+PF00586 AIR synthase related protein, N-terminal domain<br>MRC-LMB Genome Group. This family includes Hydrogen expression/formation protein  HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain  .. 
+PF02769 AIR synthase related protein, C-terminal domain<br>MRC-LMB Genome Group. This family includes Hydrogen expression/formation protein  HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site  .. 
+PF04988 A-kinase anchoring protein 95 (AKAP95)<br>Pfam-B_5366 (release 7.6). A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic  chromosome condensation by acting as a targeting molecule for the  condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA  .. 
+PF02983 AL_protease; <br>Alpha-lytic protease prodomain. 
+PF00490 Delta-aminolevulinic acid dehydratase<br>
+PF00171 aldedh; <br>Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases Swiss:P00352 EC:1.2.1.3. Succinate-semialdehyde dehydrogenase Swiss:P25526 EC:1.2.1.16. Lactaldehyde dehydrogenase Swiss:P25553 EC:1.2.1.22. Benzaldehyde dehydrogenase Swiss:P43503 EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase Swiss:Q02252 EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase Swiss:P81406 EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase Swiss:P30038 EC: 1.5.1.12. Acetaldehyde dehydrogenase Swiss:P17547 EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase Swiss:P07004 EC:1.2.1.41. This family also includes omega crystallin Swiss:P30842 an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.. 
+PF01081 KDPG and KHG aldolase<br>This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate  aldolase (KDPG-aldolase). 
+PF00596 Aldolase_class_II; <br>Class II Aldolase and Adducin N-terminal domain. MRC-LMB Genome Group. This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.. 
+PF03752 DUF312; <br>Short repeats of unknown function. This set of repeats is found in a small family of secreted proteins of no known function, though they are possibly involved in signal transduction. ALF stands for Alanine-rich (AL) - conserved Phenylalanine (F).. 
+PF05208 ALG3 protein<br>Pfam-B_3416 (release 7.7). The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man  . ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.. 
+PF03561 Allantoicase repeat<br>This family is found in pairs in Allantoicases, forming the majority of the protein. These  proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction: allantoate + H(2)0 =  (-)-ureidoglycolate + urea.. 
+PF04864 Allinase<br>Pfam-B_4527 (release 7.6). Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase (EC:4.4.1.4), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system.. 
+PF04030 D-arabinono-1,4-lactone oxidase <br>Pfam-B_33547 (release 7.3);. This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.- , which is involved in the final step of the  D-erythroascorbic acid biosynthesis pathway  .. 
+PF00128 alpha-amylase; <br>Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the  active site, interrupted by a ~70 a.a. calcium-binding domain  protruding between beta strand 3 and alpha helix 3, and a  carboxyl-terminal Greek key beta-barrel domain.. 
+PF02903 alpha-amylase_N; <br>Alpha amylase, N-terminal ig-like domain. 
+PF02296 Alpha adaptin AP2, C-terminal domain<br>Pfam-B_8859 (release 5.2). Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.. 
+PF02883 Adaptin C-terminal domain<br>Pfam-B_8859 (release 5.2). Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.  This ig-fold domain is found in alpha, beta and gamma adaptins.. 
+PF00944 Alpha_core; <br>Alphavirus core protein . Pfam-B_266 (release 3.0). Also known as coat protein C and capsid protein C. This makes the literature very confusing.  Alphaviruses consist of a nucleoprotein core, a lipid membrane which envelopes the core, and glycoprotein spikes protruding from the lipid membrane.. 
+PF01589 Alphavirus E1 glycoprotein<br>Pfam-B_587 (release 4.1). E1 forms a heterodimer with E2 Pfam:PF00943.  The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus)  .. 
+PF00943 Alphavirus E2 glycoprotein<br>Pfam-B_308 (release 3.0). E2 forms a heterodimer with E1.  The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus)  .. 
+PF01563 Alphavirus E3 glycoprotein<br>Pfam-B_285 (release 4.0). This protein is found in some alphaviruses as a virion associated spike protein  .. 
+PF03229 Alphavirus glycoprotein J<br>Pfam-B_3350 (release 6.5). 
+PF01120 Alpha-L-fucosidase<br>
+PF02232 Alpha trans-inducing protein (Alpha-TIF) <br>Pfam-B_1799 (release 5.2). Alpha-TIF, a virion protein (VP16), is involved in transcriptional activation of viral immediate early (IE) promoters (alpha genes). Specificity of Swiss:P23990 for IE genes is conferred by the  400 residue N-terminal, the 80 residue C-terminal is responsible for transcriptional activation  .. 
+PF02430 Apical membrane antigen 1<br>Pfam-B_2016 (release 5.4). Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites  .. 
+PF03913 Amb V Allergen<br>
+PF02948 Amelogenin<br>Pfam-B_402 (release 6.4). Amelogenins play a role in biomineralisation. They seem to regulate the  formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta  .. 
+PF04709 Anti-Mullerian hormone, N terminal region<br>Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation  .  Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism  . This family represents the N terminal part of the protein, which is not thought to be essential for activity  .\.  AMH contains a TGF-beta domain (Pfam:PF00019), at the C terminus.. 
+PF01425 Amidase<br>Pfam-B_191 (release 2.1). 
+PF01832 Amidase_4; <br>Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase. Pfam-B_888 (release 4.0). This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J Swiss:P75942 that has been shown to hydrolyse peptidoglycan  .. 
+PF02274 Amidinotransferase<br>Pfam-B_5784 (release 5.2) and Pfam-B_1850 (release 5.5). This family contains glycine (EC:2.1.4.1) and inosamine  (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively.  This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyse the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumour glycoprotein    (Swiss:P16962).. 
+PF01979 Adenine_deam;<br>Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily  . The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source  . This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate +  H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit  . Dihydroorotases (EC:3.5.2.3) are also included [4-5]. . 
+PF04909 Amidohydrolase<br>Pfam-B_4687 (release 7.6). These proteins are amidohydrolases that are related to Pfam:PF01979  .. 
+PF00155 aminotran_1; aminotran_1_2; <br>Aminotransferase class I and II. 
+PF00202 aminotran_3; <br>Aminotransferase class-III. 
+PF01063 AA_transferase_C4;aminotran_4; <br>Aminotransferase class IV. Pfam-B_607 (release 3.0). The D-amino acid transferases (D-AAT) are required by bacteria to  catalyse the synthesis of D-glutamic acid and D-alanine, which are  essential constituents of bacterial cell wall and are the building block for other D-amino acids.  Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.. 
+PF00266 aminotran_5; <br>Aminotransferase class-V. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.. 
+PF02293 AmiS/UreI family transporter<br>This family includes UreI and proton gated urea channel as well as putative amide transporters  .. 
+PF02461 Ammonia monooxygenase<br>Pfam-B_2301 (release 5.4). Ammonia monooxygenase plays a key role in the nitrogen cycle and degrades a wide range of hydrocarbons and halogenated hydrocarbons.. 
+PF00909 Ammonium Transporter Family<br>Pfam-B_596 (release 3.0). 
+PF05145 Putative ammonia monooxygenase<br>This family are annotated by COGS as putative ammonia monooxygenase enzymes.. 
+PF04896 Ammonia monooxygenase/methane monooxygenase, subunit C<br>Pfam-B_6611 (release 7.6). Ammonia monooxygenase plays a key role in the nitrogen cycle and degrades a wide range of hydrocarbons and halogenated hydrocarbons. This family represents the AmoC subunit. It also includes the particulate methane monooxygenase subunit PmoC from methanotrophic bacteria [1,2].. 
+PF03782 AMOP domain<br>This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges  .. 
+PF04739 5'-AMP-activated protein kinase beta subunit, interation domain<br>This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex  . This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known  .  The isoamylase N-terminal domain (Pfam:PF02922) is sometimes found in proteins belonging to this family.. 
+PF02166 Androgen receptor<br>
+PF03139 Vanadium/alternative nitrogenase delta subunit<br>Pfam-B_1227 (release 6.5). The nitrogenase complex EC:1.18.6.1 catalyses the conversion of molecular nitrogen to ammonia (nitrogen fixation) as follows: 8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP <=> 8 oxidised ferredoxin + 2 NH(3) + 16 ADP + 16 phosphate. The complex is hexameric, consisting of 2 alpha, 2 beta, and 2 delta subunits. This family represents the delta subunit of a group of nitrogenases that do not utilise molybdenum (Mo) as a cofactor, but instead use either vanadium (V nitrogenases), or iron (alternative nitrogenases). V nitrogenases are encoded by vnf operons, and alternative nitrogenases by anf operons. The delta subunits are VnfG and AnfG, respectively.. 
+PF00212 Atrial natriuretic peptide<br>
+PF03452 Anp1<br>Pfam-B_4441 (release 6.6). The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for proper Golgi function. These proteins co-localise within the cis Golgi, and that they are physically associated in two distinct  complexes .. 
+PF03374 Phage antirepressor protein KilAC domain<br>Pfam-B_3485 (release 6.6). This domain was called the KilAC domain by Iyer and colleagues  .. 
+PF04715 Anthranilate synthase component I, N terminal region<br>Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the  biosynthesis of tryptophan.  Component I catalyses the formation of  anthranilate using ammonia and chorismate.  The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family  (Pfam:PF00425). This region is involved in feedback inhibition by tryptophan  .  This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).. 
+PF03497 Anthrax toxin LF subunit<br>
+PF02522 Aminoglycoside 3-N-acetyltransferase<br>Pfam-B_1432 (release 5.4). This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic.\.      The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.. 
+PF03230 Antirestriction protein<br>Pfam-B_3190 (release 6.5). This family includes various protein that are involved in antirestriction. The ArdB protein Swiss:Q47057 efficiently inhibits restriction by members of the three known families of type I systems of E. coli  .. 
+PF03589 Antitermination protein<br>
+PF01786 Alternative oxidase<br>Pfam-B_1154 (release 4.2). The alternative oxidase is used as a second terminal oxidase  in the mitochondria, electrons are transfered directly from reduced ubiquinol to oxygen forming water  . This is not coupled to ATP synthesis and is not inhibited by cyanide, this pathway is a single step process  . In rice the transcript levels of the alternative oxidase are increased by low temperature  .. 
+PF01261 AP_endonulease2; <br>Xylose isomerase-like TIM barrel. Prosite & Pfam-B_3980 (Release 7.5). This TIM alpha/beta barrel structure is found in xylose isomerase (Swiss:P19148) and in endonuclease IV (Swiss:P12638, EC:3.1.21.2).  This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae  .. 
+PF01636 Phosphotransferase enzyme family<br>Pfam-B_840 (release 4.1). This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation  . This family also includes homoserine kinase. This family is related to fructosamine kinase Pfam:PF03881.. 
+PF02558 Ketopantoate reductase PanE/ApbA<br>This is a family of 2-dehydropantoate 2-reductases also known as  ketopantoate reductases, EC:1.1.1.169.  The reaction catalysed by this  enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway  .  ApbA and PanE are allelic  .  ApbA, the ketopantoate reductase enzyme is required for  the synthesis of thiamine via the APB biosynthetic pathway  .. 
+PF03256 Anaphase-promoting complex, subunit 10 (APC10)<br>Pfam-B_4273 (release 6.5). 
+PF04110 Ubiquitin-like autophagy protein Apg12 <br>Pfam-B_9471 (release 7.3);. In yeast, 15 Apg proteins coordinate the formation of autophagosomes.  Autophagy is a bulk degradation process induced by starvation in eukaryotic cells  . The Apg12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. It was first discovered in yeast during systematic analyses of the apg mutants defective in autophagy. Covalent attachment of Apg12-Apg5 is essential for autophagy [2,3,4].. 
+PF04108 Autophagy protein Apg17 <br>Pfam-B_71163 (release 7.3);. Apg17 is required for activating Apg1 protein kinases  .. 
+PF04111 Autophagy protein Apg6<br>Pfam-B_11747 (release 7.3);. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in  eukaryotic cells  . Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the  carboxypeptidase Y sorting pathway  .. 
+PF04109 Autophagy protein Apg9 <br>Pfam-B_12479 (release 7.3);. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in  eukaryotic cells  . Apg9 plays a direct role in the formation of the cytoplasm to  vacuole targeting and autophagic vesicles, possibly serving as a  marker for a specialised compartment essential for these  vesicle-mediated alternative targeting pathways  .. 
+PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase<br>Pfam-B_4369 (release 7.5). The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety [1,2,3].. 
+PF00807 Apidaecin<br>Pfam-B_1489 (release 2.1). These antibacterial peptides are found in bees. These heat-stable, non-helical peptides are active against a wide range of plant-associated bacteria and some human pathogens  . The Pfam alignment includes the propeptide and apidaecin sequence.. 
+PF04711 Apolipoprotein A-II (ApoA-II)<br>Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma.\.  Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge  . ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear  . In bovine serum, the ApoA-II homologue is present in almost free form.\.        Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS)  .. 
+PF04691 Apolipoprotein C-I (ApoC-1)<br>Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein.  It solubalises lipids and regulates lipid metabolism.  ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons.  ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway  . ApoC-1 has been implicated in hypertriglyceridemia  , and Alzheimer's disease  .. 
+PF01333 Apocytochrome_F; <br>Apocytochrome F, C-terminal. Pfam-B_1294 (release 3.0). This is a sub-family of cytochrome C.  See Pfam:PF00034.. 
+PF01442 Apolipoprotein A1/A4/E domain<br>Prodom_1521 (release 99.1). These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Swiss:P02647 Apolipoprotein A-I. Swiss:P06727 Apolipoprotein A-IV. Swiss:P02649 Apolipoprotein E.. 
+PF01583 Adenylylsulphate kinase<br>Pfam-B_578 (release 4.1). Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate.  This domain contains an ATP binding P-loop motif.. 
+PF03440 Aerolysin/Pertussis toxin (APT) domain<br>This family represents the N-terminal domain of aerolysin and pertussis toxin and has a type-C lectin like fold.. 
+PF02610 L-arabinose isomerase<br>This is a family of L-arabinose isomerases, AraA, EC:5.3.1.4.  These enzymes catalyse the reaction: L-arabinose <=> L-ribulose.  This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into  L-ribulose by the L-arabinose isomerases enzyme  .. 
+PF02311 AraC-like ligand binding domain<br>Pfam-B_12588 (release 5.2). This family represents the arabinose-binding and dimerisation  domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH)  DNA-binding motif Pfam:PF00165. This domain is distantly related to the Cupin domain Pfam:PF00190.. 
+PF03869 Arc-like DNA binding domain<br>Arc repressor act by he cooperative binding of two Arc repressor dimers to a 21-base-pair operator site.  Each Arc dimer uses an antiparallel beta-sheet to recognise bases in the major groove  .. 
+PF04659 Archaeal flagella protein <br>Pfam-B_4437 (release 7.5). Family of archaeal flaD and flaE proteins.  Conserved region found at N-terminus of flaE but towards the C-terminus of flaD  . . 
+PF01917 Archaebacterial flagellin<br>Enright A & COG3354 & COG3353. Members of this family are the proteins that form the flagella in archaebacteria.. 
+PF01637 Archaeal_ATPase; <br>Pfam-B_1507 (release 4.1). This family contain a conserved P-loop motif that is involved in binding ATP. This family is almost exclusively found in archaebacteria and particularly in Methanococcus jannaschii that encodes sixteen members of this family.. 
+PF00798 Arenavirus glycoprotein<br>Pfam-B_1047 (release 2.1). 
+PF00843 Arenavirus nucleocapsid protein<br>Pfam-B_1333 (release 2.1). 
+PF00025 arf; <br>ADP-ribosylation factor family. Pfam combines a number of different Prosite families together. 
+PF01316 Arginine repressor, DNA binding domain<br>
+PF02863 Arginine repressor, C-terminal domain<br>
+PF00491 arginase; <br>
+PF00764 Arginosuccinate synthase<br>Pfam-B_888 (release 2.1). This family contains a PP-loop motif  .. 
+PF01960 ArgJ family<br>Members of the ArgJ family catalyse the first EC:2.3.1.1 and fifth steps EC:2.3.1.35 in arginine biosynthesis. . 
+PF03308 ArgK protein<br>Pfam-B_3540 (release 6.5). The ArgK protein acts as an ATPase enzyme and as a kinase, and phosphorylates periplasmic binding proteins involved in the LAO (lysine, arginine, ornithine)/AO transport systems.. 
+PF02374 Anion-transporting ATPase<br>Pfam-B_1201 (release 5.2). This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell. . 
+PF02040 Arsenical pump membrane protein<br>
+PF03960 ArsC family<br>This family is related to glutaredoxins Pfam:PF00462.. 
+PF01129 NAD:arginine ADP-ribosyltransferase<br>
+PF02497 Art_glycop; <br>Arterivirus glycoprotein. Pfam-B_787 (release 5.4). This is a family of structural glycoproteins from arterivirus that corresponds to open reading frame 4 (ORF4) of the virus.. 
+PF01481 Arte_nucleocap;<br>Arterivirus nucleocapsid protein. Prodom_2418 (release 99.1). 
+PF01606 Arterivirus envelope protein<br>Pfam-B_664 (release 4.1). This family consists of viral envelope proteins from the arterivirus genus; this includes porcine reproductive and  respiratory virus (PRRSV) envelope protein GP3 and lactate  dehydrogenase elevating virus (LDV) structural glycoprotein. Arteriviruses consists of positive ssRNA and do not have a DNA stage.. 
+PF00951 Arteri_glycop; <br>Arterivirus GL envelope glycoprotein. Pfam-B_425 (release 3.0). Arteriviruses encode 4 envelope proteins, Gl, Gs, M and N. Gl   envelope protein, is encoded in ORF5, and is 30- 45 kDa in size. Gl is heterogenously glycosylated with N-acetyllactosamine in  a cell-type-specific manner. The Gl glycoprotein expresses the  neutralisation determinants.. 
+PF01097 Defensin; Arthro_defensin; <br>
+PF04161 Arv1-like family <br>Pfam-B_9351 (release 7.3);. Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis  .. 
+PF01731 Arylesterase<br>Pfam-B_2101 (release 4.1). This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity  . Human arylesterase (PON1) Swiss:P27169 is associated with HDL and may protect against LDL oxidation  .. 
+PF00858 Amiloride-sensitive sodium channel<br>Pfam-B_415 (release 3.0). 
+PF01671 African swine fever virus multigene family 360 protein<br>Pfam-B_1174 (release 4.1). The multigene family 360 protein are found within the African swine fever virus (ASF) genome which consist of dsDNA and has similar structural features to the poxyviruses  . The biological function of this family is not known  . Although Swiss:Q65137 is a major structural protein  .. 
+PF05170 AsmA family<br>The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli  . AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant  . AsmA may have a role in LPS biogenesis  .. 
+PF00733 Asparagine synthase<br>Pfam-B_443 (release 2.1). This family is always found associated with Pfam:PF00310. Members of this family catalyse the conversion of aspartate to asparagine.. 
+PF03590 Aspartate-ammonia ligase<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00026 asp; <br>Eukaryotic aspartyl protease. Aspartyl (acid) proteases include pepsins, cathepsins, and renins.  Two-domain structure, probably arising from ancestral duplication.  This family does not include the retroviral nor retrotransposon proteases (Pfam:PF00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.. 
+PF02261 Aspartate decarboxylase<br>Pfam-B_3879 (release 5.2). Decarboxylation of aspartate is the major route of beta-alanine  production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.. 
+PF00710 Asparaginase<br>Pfam-B_652 (release 2.1). 
+PF01112 Asparaginase<br>
+PF04958 Arginine N-succinyltransferase beta subunit<br>Arginine N-succinyltransferase EC:2.3.1.109 catalyses the transfer of succinyl-CoA to arginine to produce succinylarginine. This is the first step in arginine catabolism by the arginine succinyltransferase pathway.. 
+PF04996 Succinylarginine dihydrolase<br>This enzyme transforms N(2)-succinylglutamate into succinate and glutamate. This is the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway.. 
+PF04952 Aste_AspA; <br>Succinylglutamate desuccinylase / Aspartoacylase family. COG2988 & Pfam-B_15640 (release 10.0). 
+PF03115 Astrovirus capsid protein precursor<br>Pfam-B_2957 (release 6.5). This product is encoded by astrovirus ORF2, one of the three astrovirus ORFs (1a, 1b, 2). The 87kD precursor protein undergoes an intracellular cleavage to form a 79kD protein. Subsequently, extracellular trypsin cleavage yields the three proteins forming the infectious virion  .. 
+PF04377 Arginine-tRNA-protein transferase, C terminus<br>This family represents the C terminal region of the enzyme  arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway  of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis.  N terminal cysteine is sometimes  modified  .. 
+PF04376 Arginine-tRNA-protein transferase, N terminus<br>This family represents the N terminal region of the enzyme  arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway  of protein degradation by conjugating a de-stabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis.  N terminal cysteine is sometimes  modified  . In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important  for activity  .  Of these, only Cys 94 appears to be completely conserved in this family.. 
+PF03078 ATHILA ORF-1 family<br>Pfam-B_2240 (release 6.4). ATHILA is a group of Arabidopsis thaliana retrotransposons    belonging to the Ty3/gypsy family of the long terminal repeat (LTR) class of eukaryotic retrotransposons[2,3]. The central region of ATHILA retrotransposons contains two or three open reading frames (ORFs). This family represents the ORF1 product. The function of ORF1 is unknown.. 
+PF03477 ATP cone domain<br>
+PF02222 ATP-grasp domain<br>Pfam-B_157 (release 5.2). This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.. 
+PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain<br>The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.. 
+PF02807 ATP:guanido phosphotransferase, N-terminal domain<br>The N-terminal domain has an all-alpha fold.. 
+PF01747 ATP-sulfurylase<br>Pfam-B_494 (release 4.2). This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulphate  . ATP sulfurylase catalyses the synthesis of adenosine-phosphosulfate APS from ATP and inorganic sulphate  .. 
+PF00231 ATP synthase<br>
+PF05176 ATP10 protein<br>ATP 10 is essential for the assembly of a functional mitochondrial ATPase complex  .. 
+PF00895 ATP synthase protein 8<br>Pfam-B_446 (release 3.0). 
+PF00119 ATP synthase A chain<br>
+PF00006 ATP synthase alpha/beta family, nucleotide-binding domain<br>This family includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.. 
+PF00430 ATP synthase B/B' CF(0)<br>Pfam-B_137 (release 1.0). Part of the CF(0) (base unit) of the  ATP synthase. The base unit is thought to translocate protons through membrane  (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits.  This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in Pfam:PF00006. 
+PF00137 ATP synthase subunit C<br>
+PF01813 ATP synthase subunit D <br>Pfam-B_1304 (release 4.2). This is a family of subunit D form various ATP synthases including V-type H+ transporting and Na+ dependent. Subunit D is suggested to be an integral part of the catalytic sector of the V-ATPase  .. 
+PF00401 ATP synthase, Delta/Epsilon chain, long alpha-helix domain<br>Pfam-B_114 (release 1.0). Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. This subunit is called epsilon in bacteria and delta in  mitochondria.  In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).. 
+PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain<br>Pfam-B_114 (release 1.0). Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria.  In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).. 
+PF04627 ATP-synt_E;<br>Mitochondrial ATP synthase epsilon chain. This family constitutes the mitochondrial ATP synthase epsilon subunit.  This is not to be confused with the bacterial epsilon subunit, which is homologous to the mitochondrial delta subunit (Pfam:PF00401 and Pfam:PF02823) The epsilon subunit is located in the extrinsic membrane section F1, which is the catalytic site of ATP synthesis.  The epsilon subunit was not well ordered in the crystal structure of bovine F1  , but it is known to be located in the stalk region of F1  . E subunit is thought to be involved in the regulation of ATP synthase, since a null mutation increased oligomycin sensitivity and decreased inhibition by inhibitor protein IF1  .. 
+PF01990 ATP synthase (F/14-kDa) subunit<br>This family includes 14-kDa subunit from vATPases  , which is in the peripheral catalytic part of the complex  . The family also includes archaebacterial ATP synthase subunit F  .. 
+PF04911 ATP synthase j chain<br>
+PF02038 ATP1G1/PLM/MAT8 family<br>
+PF03899 ATP synthase I chain<br>
+PF03154 Atrophin-1 family<br>Pfam-B_3427 (release 6.5). Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins [1,2]. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity  .. 
+PF03769 Attacin, C-terminal region<br>Pfam-B_2791 (release 7.0). This family includes attacin, sarcotoxin and diptericin.  All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically to kill the invading microorganism  .. 
+PF03472 Autoinducer binding domain<br>This domain is found a a large family of transcriptional regulators.  This domain specifically binds to autoinducer molecules.. 
+PF00765 Autoinducer synthetase<br>Pfam-B_881 (release 2.1). 
+PF03987 Autophagy_C; <br>Autophagocytosis associated protein, active-site domain . Pfam-B_10019 (release 7.3). Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex  .. 
+PF03986 Autophagocytosis associated protein (Atg3), N-terminal domain <br>Pfam-B_10019 (release 7.3). 
+PF02309 AUX/IAA family<br>Pfam-B_801 (release 5.2). Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin. Some members of this family are longer and contain an N terminal DNA binding domain, such as Swiss:O64965. The function of this region is uncertain.. 
+PF02041 Auxin binding protein<br>
+PF02519 Auxin responsive protein<br>Pfam-B_1263 (release 5.4). This family consists of the protein products of the ARG7 auxin responsive genes family none of which have any identified functional role. . 
+PF03708 Avian retrovirus envelope protein, gp85 <br>Pfam-B_3651 (release 7.0). Family of a vain specific viral glycoproteins that forms a  receptor-binding gp85 polypeptide that is linked through disulfide  to a membrane-spanning gp37 spike.  Gp85 confers a high degree of subgroup  specificity for interaction with distinct cell receptors  .. 
+PF01382 Avidin family<br>
+PF03377 Xanthomonas avirulence protein, Avr/PthA<br>Pfam-B_3936 (release 6.6). 
+PF03591 AzlC protein<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02216 B domain<br>Pfam-B_1782 (release 5.2). This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.. 
+PF04182 B-block binding subunit of TFIIIC<br>Pfam-B_68239 (release 7.3);. Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding  .. 
+PF02246 Protein L b1 domain<br>Pfam-B_3438 (release 5.2). Protein L is a bacterial protein with immunoglobulin (Ig) light  chain-binding properties. It contains a number of homologous b1 repeats towards the N-terminus. These repeats have been found to  be responsible for the interaction of protein L with Ig light  chains  .. 
+PF03483 S3_4;<br>Pfam-B_1005 (release 7.0). This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.. 
+PF03484 tRNA synthetase B5 domain<br>Pfam-B_1005 (release 7.0). This domain is found in phenylalanine-tRNA synthetase beta subunits.. 
+PF01603 Protein phosphatase 2A regulatory B subunit (B56 family)<br>Pfam-B_984 (release 4.1). Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also Pfam:PF01240), this family is called the B56 family  .. 
+PF02043 Bacteriochlorophyll C binding protein<br>
+PF00216 Bacterial DNA-binding protein<br>
+PF00308 bac_dnaA; <br>Bacterial dnaA  protein. 
+PF01311 Bacterial export proteins, family 1<br>Pfam-B_1442 (release 3.0). This family includes the following members;     FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal  peptides, through the membrane.  Although the proteins that these exporters move may be different, the exporters are thought to  function in similar ways  .. 
+PF01312 FlhB HrpN YscU SpaS Family<br>Pfam-B_1200 (release 3.0). This family includes the following members:   FlhB, HrpN, YscU, SpaS, HrcU SsaU and YopU. All of these proteins export peptides using the type III secretion system.  The peptides exported are quite diverse.. 
+PF05088 Bacterial NAD-glutamate dehydrogenase<br>Pfam-B_6291 (release 7.7). This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to  ketoglutarate and ammonia  .. 
+PF01152 Globin;<br>Bacterial-like globin. This family of heme binding proteins are found mainly in bacteria. However they can also be found in some protozoa and plants as well.. 
+PF00296 bac_luciferase; <br>Luciferase-like monooxygenase. 
+PF01036 Bacteriorhodopsin-like protein<br>Pfam-B_1412 (release 3.0). The bacterial opsins are retinal-binding proteins that provide light- dependent ion transport and sensory functions to a family of halophilic bacteria [2,3]. They are integral membrane proteins believed to contain seven transmembrane (TM) domains, the last of which contains the attachment point for retinal (a conserved lysine). This family also includes distantly related proteins that do not contain the retinal binding lysine and so cannot function as opsins.  Some fungal examples are: Swiss:O74870, Swiss:P25619, Swiss:P38079, Swiss:Q12117.. 
+PF01103 Bac_suface_Ag; <br>Pfam-B_1201 (release 3.0). This entry includes the following surface antigens;    D15 antigen from H.influenzae,    OMA87 from P.multocida,    OMP85 from N.meningitidis and N.gonorrhoeae. The family also includes a number of eukaryotic proteins that are members of the UPF0140 family. There also appears to be a relationship to Pfam:PF03865 (personal obs: C Yeats). In eukaryotes, it appears that these proteins are not surface antigens; S. cerevisiae YNL026W (SAM50, Swiss:P53969) is an essential component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The protein was localised to the mitochondria  .. 
+PF01338 Bacillus thuringiensis toxin<br>
+PF01654 Bacterial Cytochrome Ubiquinol Oxidase<br>Pfam-B_1148 (release 4.1). This family are the alternative oxidases found in many bacteria which oxidise ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II. 
+PF00936 Bact_microcomp; Bac_microcomp; <br>Pfam-B_1071 (release 3.0). Bacterial microcompartments are primitive organelles composed entirely of protein subunits. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure  .. 
+PF02397 Bact_transf; <br>Bacterial sugar transferase. Pfam-B_1538 (release 5.4). This Pfam family represents a conserved region from a number of  different bacterial sugar transferases, involved in diverse  biosynthesis pathways.. 
+PF01721 Class II bacteriocin<br>Pfam-B_1954 (release 4.1). The bacteriocins are small peptides that inhibit the growth of various bacteria. Bacteriocins of lactic acid  bacteria may inhibit their target cells by permeabilising the cell  membrane  .. 
+PF04798 Baculovirus 19 kDa protein conserved region<br>Pfam-B_6291 (release 7.5). Family of Baculovirus proteins of approximate mass 19 kDa. . 
+PF04631 Baculovirus hypothetical protein<br>Pfam-B_5343 (release 7.5). This family includes several hypothetical baculoviral proteins, with predicted molecular weights of approximately 44 kD.. 
+PF04786 ssDNA binding protein <br>Pfam-B_6251 (release 7.5). Family of Baculovirus ssDNA binding proteins.. 
+PF04639 Baculoviral E56 protein, specific to ODV envelope<br>Pfam-B_5446 (release 7.5). This family represents the E56 protein, which is localises to the occlusion derived virus (ODV) envelope, but not to the budded virus (BV) envelope  .. 
+PF04850 Baculovirus E66 occlusion-derived virus envelope protein<br>Pfam-B_4624 (release 7.6). 
+PF03258 Baculovirus FP protein<br>Pfam-B_4275 (release 6.5). The FP protein is missing in baculovirus (Few Polyhedra) mutants  .. 
+PF04700 Structural glycoprotein p40/gp41 conserved region<br>Pfam-B_4278 (release 7.5). Family of viral structural glycoproteins  .. 
+PF03273 Baculovirus gp64 envelope glycoprotein family<br>Pfam-B_4223 (release 6.5). This family includes the gp64 glycoprotein from baculovirus as well as other viruses e.g. Swiss:P28970.. 
+PF04735 Baculovirus DNA helicase<br>Pfam-B_3393 (release 7.5). 
+PF04838 Baculoviridae late expression factor 5 <br>Pfam-B_5141 (release 7.6). 
+PF05073 Baculovirus P24 capsid protein<br>Pfam-B_6005 (release 7.7). Baculovirus P24 is associated with nucleocapsids of budded and polyhedra-derived virions [1,2].. 
+PF04766 Nucleopolyhedrovirus p26 protein<br>Pfam-B_6066 (release 7.5). Family of Baculovirus p26 proteins. . 
+PF05214 Baculo_P33; <br>Pfam-B_6583 (release 7.7). This family consists of a series of Baculovirus P33 protein homologues of unknown function.. 
+PF02961 Barrier to autointegration factor<br>The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif.  The protein is involved in the prevention of retroviral DNA integration.. 
+PF05112 Baculo_P47; <br>Baculovirus P47 protein. Pfam-B_6441 (release 7.7). This family consists of several Baculovirus P47 proteins which is one of the primary components of Baculovirus encoded RNA polymerase, which  initiates transcription from late and very late promoters  .. 
+PF04878 Baculo_P48; <br>Baculovirus P48 protein. Pfam-B_6510 (release 7.6). 
+PF04583 Baculoviridae p74 conserved region<br>Pfam-B_4744 (release 7.5). Baculoviruses are distinct from other virus families in that there are two viral phenotypes: budded virus (BV) and occlusion-derived virus (ODV). BVs disseminate viral infection throughout the tissues of the host and ODVs transmit baculovirus between insect hosts.  GFP tagging experiments implicate p74 as an ODV envelope protein [1,2].. 
+PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus <br>Polyhedra are large crystalline occlusion bodies containing  nucleopolyhedrovirus virions, and surrounded by an electron-dense  structure called the polyhedron envelope or polyhedron calyx.  The  polyhedron envelope (associated) protein PEP is thought to be an  integral part of the polyhedron envelope. PEP is concentrated at the surface of polyhedra, and is thought to be important for the proper  formation of the periphery of polyhedra.  It is thought that PEP may  stabilise polyhedra and protect them from fusion or aggregation  .. 
+PF04512 Baculovirus polyhedron envelope protein, PEP, N terminus<br>Polyhedra are large crystalline occlusion bodies containing  nucleopolyhedrovirus virions, and surrounded by an electron-dense  structure called the polyhedron envelope or polyhedron calyx.  The  polyhedron envelope (associated) protein PEP is thought to be an  integral part of the polyhedron envelope. PEP is concentrated at the surface of polyhedra, and is thought to be important for the proper  formation of the periphery of polyhedra.  It is thought that PEP may  stabilise polyhedra and protect them from fusion or aggregation  .. 
+PF04501 Baculovirus major capsid protein VP39<br>This family constitutes the 39 kDa major capsid protein of the Baculoviridae  .. 
+PF04913 Baculovirus Y142 protein<br>Pfam-B_6688 (release 7.6). 
+PF04684 BAF1 / ABF1 chromatin reorganising factor<br>ABF1 is a sequence-specific DNA binding protein involved in transcription  activation, gene silencing and initiation of DNA replication. ABF1 is known to remodel chromatin, and it is proposed that it mediates its effects on  transcription and gene expression by modifying local chromatin architecture  . These functions require a conserved stretch of 20 amino acids in the  C-terminal region of ABF1 (amino acids 639 to 662 S. cerevisiae  (Swiss:P14164))  .  The N-terminal two thirds of the protein are  necessary for DNA binding, and the N-terminus (amino acids 9 to 91 in S.  cerevisiae) is thought to contain a novel zinc-finger motif which may  stabilise the protein structure  .. 
+PF02179 BAG domain<br>Alignment kindly provided by SMART. Domain present in Hsp70 regulators.. 
+PF02923 Restriction endonuclease BamHI<br>
+PF00373 Band_41; <br>This domain is the central structural domain of the FERM domain.. 
+PF03114 BAR domain<br>BAR domains are dimerisation, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like Pfam:PF00169 and Pfam:PF00787 domains in beta centaurins and sorting nexins respectively.. 
+PF01337 Barstar (barnase inhibitor)<br>
+PF00967 Barwin family<br>
+PF04865 Baseplate J-like protein<br>Pfam-B_4777 (release 7.6). The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologues, which are thought to have been horizontally transferred.. 
+PF01586 Myogenic Basic domain<br>Pfam-B_427 (release 4.1). This basic domain is found in the MyoD family of muscle specific proteins  that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding  . With 12 residues of the basic domain involved in DNA binding  . The basic domain forms an extended alpha helix in the structure.. 
+PF02028 BCCT family transporter<br>
+PF02327 Bacteriochlorophyll A protein<br>Pfam-B_38317 (release 5.2). Bacteriochlorophyll A protein is involved in the energy transfer system of green photosynthetic bacteria. The protein forms a homotrimer, with each monomer unit containing seven molecules of bacteriochlorophyll A.. 
+PF00452 Apoptosis regulator proteins, Bcl-2 family<br>
+PF04538 Brain expressed X-linked like family <br>Pfam-B_3086 (release 7.5). This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals  . TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in Pfam:PF07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way  .. 
+PF04714 BCL7, N-terminal conserver region<br>Pfam-B_5900 (release 7.5). Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome  .. 
+PF01869 BadF/BadG/BcrA/BcrD ATPase family<br>Enright A & Pfam-B_5854 (Release 7.5). This family includes the BadF Swiss:O07462 and BadG Swiss:O07463 proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase Swiss:P11568. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerise. This family appears to be related to Pfam:PF00370.. 
+PF03170 Bacterial cellulose synthase subunit<br>Pfam-B_3954 (release 6.5). This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells.  While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalysed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognised sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase (Swiss:Q59167), which corresponds to BcsB.. 
+PF02138 Beige/BEACH domain<br>
+PF00407 Bet_v_I; <br>Pathogenesis-related protein Bet v I family. This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants  . In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10  : - Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1 (Swiss:Q8H1L1), an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones  . - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine  . -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber  . The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens (Swiss:Q9AXI3).. 
+PF03494 Beta-amyloid peptide (beta-APP)<br>
+PF00144 beta-lactamase; <br>Prosite and Pfam-B_106 (Release 7.5). This family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.. 
+PF01212 Beta-eliminating lyase<br>
+PF02929 Beta galactosidase small chain<br>Pfam-B_592 (Release 6.3). This domain comprises the small chain of dimeric beta-galactosidases EC:3.2.1.23.  This domain is also found in single chain beta-galactosidase.. 
+PF02180 Bcl-2 homology region 4<br>Alignment kindly provided by SMART. 
+PF02368 Bacterial Ig-like domain (group 2)<br>This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial and phage surface proteins such as intimins.. 
+PF04775 Acyl-CoA thioester hydrolase/BAAT N-terminal region<br>Pfam-B_2191 (release 7.6). This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT)  .  This region is not thought to contain the active site of either enzyme.  Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism  .  For example, in peroxisomes, the hydrolase acts on bile-CoA esters  .. 
+PF03496 Binary_toxA;<br>ADP-ribosyltransferase exoenzyme. This is a family of bacterial and viral bi-glutamic acid ADP-ribosyltransferases, where, in Swiss:Q93Q17, E403 is the catalytic residue and E401 contributes to the transfer of ADP-ribose to the target protein. In clostridial species it is actin that is being ADP-ribosylated; this result is lethal and dermonecrotic in infected mammals.. 
+PF03495 Clostridial binary toxin B/anthrax toxin PA<br>The N-terminal region of this family contains a  calcium-binding motif that may be an EF-hand.. 
+PF02084 Bindin<br>
+PF00351 biopterin_H; <br>Biopterin-dependent aromatic amino acid hydroxylase. This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.. 
+PF00364 biotin_req_enzy; biotin_lipoyl; <br>Biotin-requiring enzyme. This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins.. 
+PF03744 6-carboxyhexanoate--CoA ligase<br>This family contains the enzyme 6-carboxyhexanoate--CoA ligase EC:6.2.1.14. This enzyme is involved in the first step of biotin synthesis, where it converts pimelate into pimeloyl-CoA  . The enzyme requires magnesium as a cofactor and forms a homodimer  .. 
+PF02632 BioY family<br>A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin  . BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes  .. 
+PF00653 Inhibitor of Apoptosis domain<br>BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin (Swiss:O15392)  .. 
+PF04197 Birnavirus RNA dependent RNA polymerase (VP1)<br>Pfam-B_2204 (release 7.3). Birnaviruses are dsRNA viruses. This family corresponds to the RNA dependent RNA polymerase. This protein is also known as VP1. All of the birnavirus VP1 proteins contain conserved RdRp motifs that reside in the catalytic "palm" domain of all classes of polymerases. However, the birnavirus RdRps lack the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RdRps  .. 
+PF01766 Birnavirus VP2 protein<br>Pfam-B_946 (release 4.2). VP2 is the major structural protein of birnaviruses  . The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C)  .. 
+PF01767 Birnavirus VP3 protein<br>Pfam-B_946 (release 4.2). VP3 is a minor structural component of the virus. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C)  .. 
+PF01768 Birnavirus VP4 protein<br>Pfam-B_946 (release 4.2). VP4 is a viral protease  . The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C)  .. 
+PF03042 Birnavirus VP5 protein<br>Pfam-B_1772 (release 6.4). 
+PF03493 Calcium-activated BK potassium channel alpha subunit<br>
+PF04940 Sensors of blue-light using FAD<br>The BLUF domain has been shown to bind FAD in the AppA protein (Swiss:Q53119). AppA is  involved in the repression of photosynthesis genes in response to blue-light.. 
+PF02608 Basic membrane protein<br>This is a family of basic membrane lipoproteins form Borrelia and various putative lipoproteins form other bacteria.  All of these proteins are  outer membrane proteins and are thus antigenic in nature when possessed by the pathogenic members of the family.  One protein Swiss:032436 is a transcriptional activator  .. 
+PF01722 BolA-like protein<br>Pfam-B_1996 (release 4.1). This family consist of the morphoprotein BolA from E. coli and its various homologues. In E. coli over expression of this protein causes round morphology and may be involved in  switching the cell between elongation and septation systems during  cell division  . The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase  . BolA is also induced by stress during early stages of  growth   and may have a general role in stress response.  It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [2,1].. 
+PF02044 Bombesin-like peptide<br>
+PF02414 Borrelia ORF-A<br>Pfam-B_1805 (release 5.4). This protein is encoded by an open reading frame in plasmid borne DNA repeats of Borrelia species. This protein is known as ORF-A  . The function of this putative protein is unknown.. 
+PF03183 Borrelia repeat protein<br>Pfam-B_2029 (release 6.5). 
+PF00228 Bowman-Birk serine protease inhibitor family<br>
+PF02653 Branched-chain amino acid transport system / permease component<br>COG0559 & Pfam-B_654 (Release 7.5). This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH Swiss:P08340 and LivM  Swiss:P22729 both of which are form the LIV-I transport system  . Also found with in this family are proteins from the galactose transport system permease   and a ribose transport system  .. 
+PF00634 BRCA2_repeat;<br>The alignment covers only the most conserved region of the repeat.. 
+PF02498 BRO; <br>BRO family, N-terminal domain. Pfam-B_1235 (release 5.4). This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown.  It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription  . This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins  .. 
+PF03032 Brevenin/esculentin/gaegurin/rugosin family<br>Pfam-B_1232 (release 6.4). This family contains a number of defence peptides secreted from the skin of amphibians, including the opiate-like dermorphins and deltorphins, and the antimicrobial  dermoseptins and temporins. The alignment for this family includes the signal peptide.. 
+PF01318 Bromo_CP; <br>Bromovirus coat protein. 
+PF01573 Bromovirus movement protein<br>Pfam-B_508 (release 4.1). 
+PF04450 Peptidase of plants and bacteria<br>Pfam-B_5066 (release 7.5). These basic secretory proteins (BSPs) are believed to be part of the plants defence mechanism against pathogens  . . 
+PF00779 BTK motif<br>Alignment kindly provided by SMART. Zinc-binding motif containing conserved cysteines and a histidine. Always found C-terminal to PH domains. The crystal structure   shows this motif packs against the PH domain. The PH+Btk module pair has been called the Tec homology (TH) region  .. 
+PF04514 Bluetongue virus non-structural protein NS2<br>This family includes NS2 proteins from other members of the Orbivirus genus.  NS2 is a non-specific single-stranded RNA-binding protein that forms large homomultimers and accumulates in viral inclusion bodies of infected cells. Three RNA binding regions have been identified in Bluetongue virus serotype 17 (Swiss:P33473) at residues 2-11, 153-166 and 274-286  . NS2 multimers also possess nucleotidyl phosphatase activity  . The precise function of NS2 is not known, but it may be involved in the transport and condensation of viral mRNAs  .. 
+PF04426 Bul1 C terminus<br>This family contains the C terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524)  .  The complex containing Bul1 and Rsp5 is involved in  intracellular trafficking of the general amino acid permease Gap1  , degradation of Rog1 in cooperation with Bul2 and GSK-3  , and  mitochondrial inheritance  . Bul1 may contain HEAT repeats.. 
+PF04425 Bul1 N terminus<br>This family contains the N terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524)  .  The complex containing Bul1 and Rsp5 is involved in  intracellular trafficking of the general amino acid permease Gap1  , degradation of Rog1 in cooperation with Bul2 and GSK-3  , and  mitochondrial inheritance  . Bul1 may contain HEAT repeats.. 
+PF03557 Bunyavirus glycoprotein G1<br>Pfam-B_653 (release 7.0). Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G1 glycoprotein which is the viral attachment protein  .. 
+PF03563 Bunyavirus glycoprotein G2<br>Pfam-B_1048 (release 7.0). Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G2 glycoprotein which interacts with the Pfam:PF03557 G1 glycoprotein  .. 
+PF01104 Bunyavirus non-structural protein NS-s<br>Pfam-B_880 (release 3.0). The NS-s protein is encoded by the S RNA. This segment also encodes for the N protein.  These two proteins are encoded by overlapping reading frames.. 
+PF03231 Bunyavirus non-structural protein NS-S<br>Pfam-B_3018 (release 6.5). This family represents the Bunyavirus NS-S family. Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.. 
+PF00952 Bunyavirus nucleocapsid (N) protein<br>Pfam-B_587 (release 3.0). The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein  is encode on the small (S) genomic RNA. The N protein is the major  component of the nucleocapsids.  This protein is thought to  interact with the L protein, virus RNA and/or other N proteins.. 
+PF04196 Bunyavirus RNA dependent RNA polymerase<br>Pfam-B_2559 (release 7.3). The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein is encode on the small (S) genomic RNA. The L segment codes for an RNA polymerase. This family contains the RNA dependent RNA polymerase on the L segment.. 
+PF03181 BURP domain<br>Pfam-B_1432 (release 6.5). The BURP domain is found at the C-terminus of several different plant proteins. It was named after the proteins in which it was first  identified: the BNM2 clone-derived protein from Brassica napus Swiss:O65009; USPs and USP-like proteins Swiss:P21746 Swiss:P21747 Swiss:Q06765  Swiss:O24482; RD22 from Arabidopsis thaliana Swiss:Q08298; and PG1beta from Lycopersicon esculentum Swiss:Q40161. This domain is around 230 amino acid residues long. It possesses the following conserved features: two phenylalanine residues at its N-terminus; two cysteine residues; and four repeated cysteine-histidine motifs, arranged as: CH-X(10)-CH-X(25-27)-CH-X(25-26)-CH, where X can be any amino acid  . The function of this domain is unknown.. 
+PF03309 Bvg_acc_factor;<br>Type III pantothenate kinase. Pfam-B_3452 (release 6.5). Type III pantothenate kinase catalyses the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.. 
+PF04681 Blastomyces yeast-phase-specific protein<br>Pfam-B_5640 (release 7.5). The molecular function of this protein is not known. Its expression is specific to the high temperature, unicellular yeast morphology (as opposed to the lower temperature, multicellular mycelium form)  .. 
+PF00170 bZIP;<br>bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.. 
+PF00386 C1q domain<br>C1q is  a subunit of the C1 enzyme complex that activates the serum complement system.. 
+PF01413 C-terminal tandem repeated domain in type 4 procollagen<br>Ponting CP, Schultz J, Bork P. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.. 
+PF03595 C4dic_mal_tran;<br>Voltage-dependent anion channel. This family of transporters has ten alpha helical transmembrane segments  .  The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterised as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore  . Many homologues are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.. 
+PF01681 C6 domain<br>This domain of unknown function is found in the C. elegans protein Swiss:Q19522. It is presumed to be an extracellular domain.  The C6 domain contains six conserved cysteine residues in most copies of the domain. However some copies of the domain are missing cysteine residues 1 and 3 suggesting that these form a disulphide bridge.. 
+PF03596 Cadmium resistance transporter<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00028 cadherin; <br>Swissprot_feature_table. 
+PF01049 Cadherin_C_term; <br>Cadherin cytoplasmic region. Pfam-B_257 (release 3.0). Cadherins are vital in cell-cell adhesion during tissue differentiation.  Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the   cadherin.  Cadherins cluster to form foci of homophilic binding units.  A key determinant to the strength of the  binding that it is mediated by cadherins is the juxtamembrane region of the cadherin.  This region induces clustering  and also binds to the protein p120ctn  .. 
+PF03507 CagA exotoxin<br>Pfam-B_918 (release 7.0). 
+PF03524 cagX; <br>Conjugal transfer protein. PRINTS & Pfam-B_5812 (Release 7.5). This family includes type IV secretion system CagX conjugation protein. Other members of this family are involved in conjugal transfer to plant cells of T-DNA.. 
+PF03185 Calcium-activated potassium channel, beta subunit<br>Pfam-B_2176 (release 6.5). 
+PF00214 Calcitonin / CGRP / IAPP family<br>
+PF04847 Calcipressin<br>Pfam-B_4547 (release 7.6). Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain  .. 
+PF02029 Caldesmon<br>
+PF05042 Caleosin related protein<br>Pfam-B_5163 (release 7.7). This family contains plant proteins related to caleosin. Caleosins contain calcium-binding domains and have an oleosin-like association with lipid  bodies. Caleosins are present at relatively low levels and are mainly bound to microsomal membrane fractions at the early stages of seed development. As the seeds mature, overall levels of caleosins increased dramatically and they were associated almost exclusively with storage lipid bodies  . This family is probably related to EF hands Pfam:PF00036.. 
+PF00915 Calicivirus coat protein<br>Pfam-B_202 (release 3.0). 
+PF01067 Calpain large subunit, domain III<br>Pfam-B_852 (release 3.0). The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.. 
+PF00748 Calpain inhibitor<br>Pfam-B_543 (release 2.1). This region is found multiple times in calpain inhibitor proteins.. 
+PF00402 calponin; <br>Calponin family repeat. 
+PF00262 calreticulin; <br>
+PF01216 Calsequestrin<br>
+PF03160 Calx-beta domain<br>
+PF01213 CAP; <br>Adenylate cyclase associated (CAP) N terminal. 
+PF04451 Capsid_Iridovir; <br>Large eukaryotic DNA virus major capsid protein. DOMO:DM04206; Iyer L. This family includes the major capsid protein of iridoviruses, chlorella virus and Spodoptera ascovirus, which are all dsDNA viruses with no RNA stage. This is the most abundant structural protein and can account for up to 45% of virion protein  .  In Chlorella virus PBCV-1 the major capsid protein is a glycoprotein  . The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, are referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV. The virions of different NCLDV have dramatically different structures. The major capsid proteins of iridoviruses and phycodnaviruses, both of which have icosahedral capsids surrounding an inner lipid membrane, showed a high level of sequence conservation. A more limited, but statistically significant sequence similarity was observed between these proteins and the major capsid protein (p72) of ASFV, which also has an icosahedral capsid. It was surprising, however, to find that all of these proteins shared a conserved domain with the poxvirus protein D13L, which is an integral virion component thought to form a scaffold for the formation of viral crescents and immature virion  .. 
+PF05159 Capsule polysaccharide biosynthesis protein<br>This family includes export proteins involved in capsule polysaccharide biosynthesis, such as KpsS Swiss:P42218 and LipB Swiss:P57038.. 
+PF00194 carb_anhydrase; <br>Eukaryotic-type carbonic anhydrase. 
+PF02977 Carboxypeptidase A inhibitor<br>
+PF00619 Caspase recruitment domain<br>Ponting C, Schultz J, Bork P. Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (Pfam:PF00531) domain-like fold .. 
+PF01623 Carlavirus putative nucleic acid binding protein<br>Pfam-B_808 (release 4.1). This family of carlavirus nucleic acid binding proteins includes a motif for a potential C-4 type zinc finger this has four highly conserved cysteine residues and is a conserved feature of the carlaviruses 3' terminal ORF  . These proteins may function as viral transcriptional regulators. The carlavirus family includes garlic latent virus and potato virus S and M, these viruses are positive strand, ssRNA with no DNA stage.. 
+PF00997 casein_kappa; <br>Pfam-B_1298 (release 3.0). Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.. 
+PF00363 caseins; <br>
+PF00302 Chloramphenicol acetyltransferase<br>
+PF03123 CAT RNA binding domain<br>P39805/1-60 Psi-blast. This RNA binding domain is found at the amino terminus of transcriptional antitermination proteins such as BglG, SacY and LicT. These proteins control the expression of sugar metabolising operons in Gram+ and Gram- bacteria. This domain has been called the CAT (Co-AntiTerminator) domain. It binds as a dimer   to short Ribonucleotidic Anti-Terminator (RAT) hairpin, each monomer interacting symmetrically with both strands of the RAT hairpin  . In the full-length protein, CAT is followed by two phosphorylatable PTS regulation domains (Pfam:PF00874) that modulate the RNA binding activity of CAT. Upon activation, the dimeric proteins bind to RAT targets in the nascent mRNA, thereby preventing abortive dissociation of the RNA polymerase from the DNA template  .. 
+PF00199 catalase; <br>
+PF00666 Cathelicidin<br>Pfam-B_276 (release 2.1). A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.. 
+PF04731 Caudal like protein activation region<br>This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family.  This region is thought to mediate transcription activation.  The level of activation caused by mouse Cdx2  (Swiss:P43241) is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway  .  Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (Pfam:PF00046).. 
+PF00689 Na_K_ATPase_C;<br>Cation transporting ATPase, C-terminus. Pfam-B_137 (release 2.1). Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.. 
+PF03310 Caulimovirus DNA-binding protein<br>Pfam-B_3746 (release 6.5). 
+PF03233 Caulimo_AT; <br>Aphid transmission protein. Pfam-B_3118 (release 6.5). This protein is found in various caulimoviruses. It codes for an 18 kDa protein (PII), which is dispensable for infection but which is required for aphid transmission of the virus  . This protein interacts with the PIII protein  .. 
+PF01693 Caulimo_VI;<br>Caulimovirus viroplasmin. Pfam-B_1373 (release 4.1). This family consists of various caulimovirus viroplasmin proteins.  The viroplasmin protein is encoded by gene VI and is the main component of viral inclusion bodies or viroplasms  . Inclusions are the site of viral assembly, DNA synthesis and accumulation  . Two domains exist within gene VI corresponding approximately to the 5' third and middle third of gene VI, these influence systemic infection in a light-dependent manner  .. 
+PF04771 Chicken anaemia virus VP-3 protein<br>Pfam-B_2147 (release 7.6). This protein is found in the nucleus of infected cells and may act as a transcriptional regulator.  It induces apoptosis, and is also known as apoptin [SwissProt annotation for Swiss:P54094].. 
+PF01146 Caveolin<br>All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localised and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumour suppression  .. 
+PF02275 Linear amide C-N hydrolases, choloylglycine hydrolase family<br>Pfam-B_5806 (release 5.2). This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides.  These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, Pfam:PF15508.. 
+PF03914 CBF/Mak21 family<br>Wood V, Griffiths-Jones SR. Pfam-B_3822 (release 7.2). 
+PF02312 Core binding factor beta subunit<br>Pfam-B_12381 (release 5.2). Core binding factor (CBF) is a heterodimeric transcription  factor essential for genetic regulation of hematopoiesis and  osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold  .. 
+PF02045 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B<br>
+PF00808 Archael_histone; Arch_histone; <br>Histone-like transcription factor (CBF/NF-Y) and archaeal histone. Pfam-B_1351 (Rel 2.1) & Pfam-B_3673 (Rel 7.5) & Pfam-B_2078 (Rel 8.0). This family includes archaebacterial histones and histone like transcription factors from eukaryotes.. 
+PF01656 CBIA;<br>CobQ/CobB/MinD/ParA nucleotide binding domain. Pfam-B_782 (release 4.1). This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA Swiss:P29946 and CbiP Swiss:Q05597 from  S.typhimurium  , and CobQ Swiss:Q52686 from R. capsulatus  . These amidases catalyse amidations to various side chains of  hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis  of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many  plants and animals and is primarily produced by bacteria  . The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family  .. 
+PF02570 Precorrin-8X methylmutase<br>This is a family Precorrin-8X methylmutases also known as Precorrin  isomerase, CbiC/CobH,  EC:5.4.1.2.  This enzyme catalyses the reaction: Precorrin-8X <=> hydrogenobyrinate.  This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyses a methyl rearrangement  [1,2].. 
+PF01888 CbiD<br>CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process  .. 
+PF01890 CbiG; <br>Cobalamin synthesis G C-terminus. Members of this family are involved in cobalamin synthesis.  The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process  . Within the cobalamin synthesis pathway CbiG catalyses the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B  . This family is the C-terminal region, and the mid- and N-termival parts are conserved independently in other families.. 
+PF02571 Precorrin-6x reductase CbiJ/CobK<br>This family consists of Precorrin-6x reductase EC:1.3.1.54. This enzyme catalyses the reaction: precorrin-6Y + NADP(+)  <=> precorrin-6X + NADPH.  CbiJ and CobK both catalyse the reduction of macocycle in the colbalmin biosynthesis pathway [1,2].. 
+PF01891 Cobalt uptake substrate-specific transmembrane region<br>This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein  . The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway  . The NikM protein is Pfam:PF10670.. 
+PF02553 Cobalt transport protein component CbiN<br>CbiN is part of the active cobalt transport system involved in  uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12).  It has been suggested that CbiN may function as the periplasmic binding protein component of the active cobalt transport  system  .. 
+PF02361 Cobalt transport protein<br>Pfam-B_673 (release 5.2). This family consists of various cobalt transport proteins Most of which are found in Cobalamin (Vitamin B12) biosynthesis operons.  In Salmonella the cbiN cbiQ (product CbiQ in this family) and cbiO are likely to form an active cobalt transport system  .. 
+PF01903 CbiX<br>The function of CbiX is uncertain, however it is found in cobalamin biosynthesis operons and so may have a related function. Some CbiX proteins contain a striking histidine-rich region at their C-terminus, which suggests that it might be involved in metal chelation  .. 
+PF02262 CBL proto-oncogene N-terminal domain 1<br>Pfam-B_3949 (release 5.2). Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.. 
+PF02761 CBL proto-oncogene N-terminus, EF hand-like domain<br>Pfam-B_3949 (release 5.2). Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.. 
+PF02762 CBL proto-oncogene N-terminus, SH2-like domain<br>Pfam-B_3949 (release 5.2). Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.. 
+PF00734 CBD_fungal; CBD_1; <br>Fungal cellulose binding domain. Pfam-B_444 (release 2.1). 
+PF02013 CBD_5; <br>Cellulose or protein binding domain. PSI-BLAST P10476/668-713. This domain is found in two distinct sets of proteins with different functions. Those found in aerobic bacteria bind cellulose (or other carbohydrates); but in anaerobic fungi they are protein binding domains, referred to as dockerin domains or docking domains. They are believed to be responsible for the assembly of a multiprotein cellulase/hemicellulase complex, similar to the cellulosome found in certain anaerobic bacteria.. 
+PF03425 Carbohydrate binding domain (family 11)<br>
+PF03426 Carbohydrate binding domain (family 15)<br>
+PF03424 CBM_28;<br>Carbohydrate binding domain (family 17/28). 
+PF03427 Carbohydrate binding domain (family 19)<br>
+PF00553 CBD_1; CBD_2; <br>Cellulose binding domain. Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.. 
+PF00686 CBD_2; CBD_4; <br>Starch binding domain. Pfam-B_111 (release 2.1). 
+PF03370 PRS; <br>Putative phosphatase regulatory subunit. Pfam-B_2433 (release 6.6). This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localises it to glycogen.  Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.. 
+PF03423 Carbohydrate binding domain (family 25)<br>
+PF02839 CBD_7; CBM_5; <br>Carbohydrate binding domain. This short domain is found in many different glycosyl hydrolase enzymes and is presumed to have a carbohydrate binding function. The domain has six aromatic groups that may be important for binding.. 
+PF04942 CC domain<br>Pfam-B_4563 (release 7.5). This short domain contains four conserved cysteines that probably for two disulphide bonds. The domain is named after the characteristic CC motif.. 
+PF01845 CcdB protein<br>
+PF04995 Heme exporter protein D (CcmD)<br>The CcmD protein is part of a C-type cytochrome biogenesis operon  .  The exact function of this protein is uncertain. It has been proposed that CcmC, CcmD and CcmE interact directly with each other, establishing a cytoplasm to periplasm haem delivery pathway for cytochrome c maturation  . This protein is found fused to CcmE in Swiss:P52224. These proteins contain a predicted transmembrane helix.. 
+PF03100 CcmE<br>Pfam-B_2583 (release 6.4). CcmE is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor.. 
+PF03918 Cytochrome C biogenesis protein<br>Members of this family include NrfF, CcmH, CycL, Ccl2.. 
+PF03597 Cytochrome oxidase maturation protein cbb3-type<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03150 Di-haem cytochrome c peroxidase<br>Pfam-B_3135 (release 6.5). This is a family of distinct cytochrome c peroxidases (CCPs) that contain two haem groups. Similar to other cytochrome c peroxidases, they reduce hydrogen peroxide to water using c-type haem as an oxidisable substrate. However, since they possess two, instead of one, haem prosthetic groups, bacterial CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two haem groups have significantly different redox potentials. The high potential (+320 mV) haem feeds electrons from electron shuttle proteins to the low potential (-330 mV) haem, where peroxide is reduced (indeed, the low potential site is known as the peroxidatic site)  . The CCP protein itself is structured into two domains, each containing one c-type haem group, with a calcium-binding site at the domain interface. This family also includes MauG proteins, whose similarity to di-haem CCP was previously recognised  .. 
+PF04505 CD225;<br>Interferon-induced transmembrane protein. Pfam-B_2070 (release 7.5). This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression  .. 
+PF01130 CD36 family<br>Pfam-B_1229 (release 3.0). The CD36 family is thought to be a novel class of scavenger  receptors.  There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.. 
+PF04549 CD47 transmembrane region<br>Pfam-B_2739 (release 7.5). This family represents the transmembrane region of CD47 leukocyte antigen [1-2].. 
+PF03234 Cdc37;CDC37; <br>Cdc37 N terminal kinase binding. Pfam-B_3345 (release 6.5). Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domain corresponds to the N terminal domain which binds predominantly to protein kinases   and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain Pfam:PF08565.  Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability.  This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function  .. 
+PF02724 CDC45-like protein<br>Pfam-B_1919 (release 5.5). CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae (Swiss:Q08032), forming a complex with MCM5/CDC46. Homologues of CDC45 have been identified in  human  , mouse and smut fungus (Swiss:Q99107) among others. . 
+PF02933 cdc48_2; <br>Cell division protein 48 (CDC48), domain 2. Pfam-B_799 (release 5.2). This domain has a double psi-beta barrel fold and includes VCP-like  ATPase and N-ethylmaleimide sensitive fusion protein N-terminal  domains.  Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate  185-residue recognition domain  .. 
+PF02359 VAT-Nn; cdc48_N; <br>Cell division protein 48 (CDC48), N-terminal domain. Pfam-B_799 (release 5.2). This domain has a double psi-beta barrel fold and includes VCP-like  ATPase and N-ethylmaleimide sensitive fusion protein N-terminal  domains.  Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate  185-residue recognition domain  .. 
+PF03381 DUF284; <br>LEM3 (ligand-effect modulator 3) family / CDC50 family. Pfam-B_2846 (release 6.6). Members of this family have been predicted to contain transmembrane helices. The family member LEM3 (Swiss:P42838) is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells  . The products of genes YNR048w (Swiss:P53740), YNL323w (Swiss:P42838) and YCR094w (Swiss:P25656) (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39  . CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure  . One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway  . It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants   may be due to inactivation of CDC39.  The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.. 
+PF02611 CDP-diacylglycerol pyrophosphatase<br>This is a family of CDP-diacylglycerol pyrophosphatases, EC:3.6.1.26.  This enzyme catalyses the reaction CDP-diacylglycerol + H2O <=> CMP + phosphatidate.. 
+PF03598 CO dehydrogenase/acetyl-CoA synthase complex beta subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03599 CO dehydrogenase/acetyl-CoA synthase delta subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02234 Cyclin-dependent kinase inhibitor<br>Pfam-B_1698 (release 5.2) & Pfam-B_5787 (Release 8.0). Cell cycle progression is negatively controlled by cyclin-dependent  kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.. 
+PF03261 Cyclin-dependent kinase 5 activator protein<br>Pfam-B_4160 (release 6.5). 
+PF05174 Cysteine-rich D. radiodurans N terminus<br>This domain is found individually and at the N terminus of a few multi-domain proteins. . 
+PF03498 Cytolethal distending toxin A/C family<br>
+PF00272 cecropin; <br>
+PF02927 celD_N; <br>N-terminal ig-like domain of cellulase. 
+PF03500 Cellulose synthase subunit D<br>
+PF03552 Cellulose synthase<br>Pfam-B_1346 (release 7.0). Cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues, is the major component of wood and thus paper, and is synthesised by plants, most algae, some bacteria and fungi, and even some animals. The genes that synthesise cellulose in higher plants differ greatly from the well-characterised genes found in Acetobacter and Agrobacterium sp. More correctly designated as 'cellulose synthase catalytic subunits', plant cellulose synthase (CesA) proteins are integral membrane proteins, approximately 1,000 amino acids in length.  There are a number of highly conserved residues, including several motifs shown to be necessary for processive glycosyltransferase activity  .. 
+PF03040 CemA family<br>Pfam-B_1775 (release 6.4). Members of this family are probable integral membrane proteins.  Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane  . A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself  . They are predicted to be haem-binding however this has not been proven experimentally  .. 
+PF03879 Cgr1 family<br>Members of this family are coiled-coil proteins that are involved in pre-rRNA processing  .. 
+PF04752 ChaC-like protein<br>Pfam-B_3722 (release 7.5). The ChaC protein is thought to be associated with the putative ChaA Ca2+/H+ cation transport protein in Escherichia coli. Its function is not known. This family also includes homologues regions from several other bacterial and eukaryotic proteins.. 
+PF00195 Chal_stil_synt; <br>Chalcone and stilbene synthases, N-terminal domain. The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase.\.   The differences in activity are accounted for by differences in this N-terminal domain.. 
+PF02797 Chal_stil_syntC; <br>Chalcone and stilbene synthases, C-terminal domain. This domain of chalcone synthase is reported to be structurally  similar to domains in thiolase and beta-ketoacyl synthase.   The differences in activity are accounted for by differences  in the N-terminal domain.. 
+PF02431 Chalcone-flavanone isomerase<br>Pfam-B_2073 (release 5.4). 
+PF03502 Nucleoside-specific channel-forming protein, Tsx<br>
+PF03924 CHASE domain<br>This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases [1,2].  Predicted to be a ligand binding domain  .. 
+PF03173 Putative carbohydrate binding domain<br>Pfam-B_8666 (release 6.5). This domain represents the N terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure that is similar in structure to the cellulose binding domain of cellulase from Cellulomonas fimi  .  This suggests that this may be a carbohydrate binding domain.. 
+PF03174 Chitobiase/beta-hexosaminidase C-terminal domain<br>Pfam-B_8666 (release 6.5). This short domain represents the C terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure  . The function of this domain is unknown.. 
+PF01339 CheB methylesterase<br>
+PF04509 CheC-like family<br>The restoration of pre-stimulus levels of the chemotactic response regulator, CheY-P, is important for allowing bacteria to respond to new environmental stimuli.  The members of this family, CheC, CheX, CheA and FliY are CheY-P phosphatase [1,2]. CheC appears to be primarily involved in restoring normal CheY-P levels, whereas FliY seems to act on CheY-P constitutively. CheD enhances the activity of CheC 5-fold, which is normally relatively low [1,2].  In some cases, the region represented by this entry is present as multiple copies.. 
+PF03975 CheD chemotactic sensory transduction<br>This chemotaxis protein stimulates methylation of MCP proteins  . The chemotaxis machinery of Bacillus subtilis is similar to that of the well characterised system of Escherichia coli. However, B. subtilis contains several chemotaxis genes not found in the E. coli genome, such as CheC and CheD, indicating that the B. subtilis chemotactic system is more complex. CheD plays an important role in chemotactic sensory transduction for many organisms. CheD deamidates other B. subtilis chemoreceptors including McpB and McpC. Deamidation by CheD is required for B. subtilis chemoreceptors to effectively transduce signals to the CheA kinase  . The structure of a complex between the signal-terminating phosphatase, CheC, and the receptor-modifying deamidase, CheD, reveals how CheC mimics receptor substrates to inhibit CheD and how CheD stimulates CheC phosphatase activity. CheD resembles other cysteine deamidases from bacterial pathogens that inactivate host Rho-GTPases. Phospho-CheY, the intracellular signal and CheC target, stabilises the CheC-CheD complex and reduces availability of CheD  . A model is proposed whereby CheC acts as a CheY-P-induced regulator of CheD; CheY-P would cause CheC to sequester CheD from the chemoreceptors, inducing adaptation of the chemotaxis system  .. 
+PF01739 CheR methyltransferase, SAM binding domain<br>Pfam-B_694 (release 4.2). CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase - the C-terminal domain (this one) binds SAM.. 
+PF03705 CheR methyltransferase, all-alpha domain<br>Pfam-B_694 (release 4.2). CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase.. 
+PF01584 CheW-like domain<br>Pfam-B_579 (release 4.1). CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis.  The CheW-like regulatory domain in CheA   binds to CheW, suggesting that these domains can interact with each other.. 
+PF01111 Cyclin-dependent kinase regulatory subunit<br>
+PF04344 Chemotaxis phosphatase, CheZ<br>This family represents the bacterial chemotaxis phosphatase, CheZ. This protein forms a dimer characterised by a long four-helix bundle, composed of two helices from each monomer. CheZ dephosphorylates CheY in a reaction that is essential to maintain a continuous chemotactic response to environmental changes. It is thought that CheZ's conserved residue Gln 147 orientates a water molecule for nucleophilic attack at the CheY active site.. 
+PF00187 chitin_binding; <br>Chitin recognition protein. 
+PF01644 Chitin_synth; <br>Pfam-B_892 (release 4.1). This region is found commonly in chitin synthases classes I, II and III. Chitin a linear homopolymer of GlcNAc residues, it is an important component of the cell wall of fungi and is synthesised on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases  .. 
+PF03142 Chitin synthase<br>Pfam-B_1787 (release 6.5). Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyse chitin synthesis as follows:  UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).. 
+PF03503 Chlamydia cysteine-rich outer membrane protein 3<br>PRINTS, Griffiths-Jones SR. 
+PF03504 Chlamydia cysteine-rich outer membrane protein 6<br>PRINTS, Griffiths-Jones SR. 
+PF01308 Chlamydia_OMP; <br>Chlamydia major outer membrane protein. Pfam-B_1429 (release 3.0). The major outer membrane protein of Chlamydia contains four symmetrically spaced variable domains (VDs I to IV).  This protein is believed to be an integral part to the pathogenesis, possibly adhesion. Along with the lipopolysaccharide, the major out membrane  protein (MOMP) makes up the surface of the elementary body cell.   The MOMP is the protein used to determine the different serotypes.. 
+PF00504 chloroa_b-bind;<br>Chlorophyll A-B binding protein. Pfam-B_54 (release 1.0) & Pfam-B_5772 (Release 7.5). 
+PF02962 5-carboxymethyl-2-hydroxymuconate isomerase<br>
+PF04428 Choline kinase N terminus<br>Found N terminal to choline/ethanolamine kinase regions (Pfam:PF01633) in some plant and fungal choline kinase enzymes (EC:2.7.1.32).  This region is only found in some members of the choline kinase family, and is therefore unlikely to contribute to catalysis.. 
+PF01633 Choline/ethanolamine kinase<br>Pfam-B_1165 (release 4.1). Choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway  . This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family. . 
+PF04345 Chorismate lyase<br>Chorismate lyase catalyses the first step in ubiquinone synthesis, i.e. the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate.. 
+PF01723 Chorion; <br>Pfam-B_1914 (release 4.1). This family consists of the chorion superfamily proteins classes A, B, CA, CB and high-cysteine HCB from silk,  gypsy and polyphemus moths. The chorion proteins make up the moths egg shell a complex extracellular structure  .. 
+PF03964 Chorion family 2<br>The chorion genes of Drosophila are amplified in  response to developmental signals in the follicle  cells of the ovary . . 
+PF00425 chorismate_bind; <br>chorismate binding enzyme. Pfam-B_164 (release 1.0). This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.. 
+PF01817 Chorismate_mut; <br>Chorismate mutase type II. Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].. 
+PF01264 Chorismate_synth;<br>
+PF02417 Chromate transporter<br>Pfam-B_1872 (release 5.4). Members of this family probably act as chromate transporters [1,2].  Members of this family are found in both bacteria and archaebacteria.  The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.. 
+PF00385 chromo; <br>Chromo (CHRromatin Organisation MOdifier) domain. 
+PF01393 Chromo shadow domain<br>This domain is distantly related to Pfam:PF00385. This domain is always found in association with a chromo domain.. 
+PF00878 CIMR_repeat;<br>Cation-independent mannose-6-phosphate receptor repeat. Pfam-B_764 (release 3.0). The cation-independent mannose-6-phosphate receptor contains 15 copies of a repeat.. 
+PF02464 Competence-damaged protein<br>Pfam-B_2197 (release 5.4). CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some  stage in the process of transformation  . This Pfam family  consists of putative competence-damaged proteins from the  cin operon.. 
+PF04162 Circo_coat; <br>Gyrovirus capsid protein (VP1). Pfam-B_1772 (release 7.3). Gyroviruses are small circular single stranded viruses. This family includes the VP1 protein from the chicken anaemia virus which is the viral capsid protein.. 
+PF02443 Circo_ORF2; <br>Circovirus capsid protein. Pfam-B_1890 (release 5.4). Circoviruses are small circular single stranded viruses.  This family is the capsid protein from viruses such as porcine circovirus   and beak and feather disease virus Swiss:Q9YUC8. These proteins are about 220 amino acids long.. 
+PF04487 CITED<br>Pfam-B_3987 (release 7.5). CITED, CBP/p300-interacting transactivator with ED-rich tail,  are characterised by a conserved 32-amino acid sequence at  the C-terminus. CITED proteins do not bind DNA directly  and are thought to function as transcriptional co-activators  . . 
+PF04223 Citrate lyase, alpha subunit (CitF)<br>In citrate-utilising prokaryotes, citrate lyase EC:4.1.3.6 cleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits. The gamma subunit serves as an acyl carrier protein (ACP), and has a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group. The citrate lyase is active only if this prosthetic group is acetylated; this acetylation is catalysed by an acetate:SH-citrate lyase ligase. The alpha subunit substitutes citryl for the acetyl group to form citryl-S-ACP. The beta subunit completes the reaction by cleaving the citryl to yield oxaloacetate and (regenerated) acetyl-S-ACP. This family represents the alpha subunit EC:2.8.3.10.. 
+PF01874 ATP:dephospho-CoA triphosphoribosyl transferase <br>The citG gene is found in a gene cluster with citrate lyase subunits  .  The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase [2-3].. 
+PF03600 Citrate transporter<br>
+PF00285 citrate_synt; <br>
+PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase<br>
+PF01214 Casein kinase II regulatory subunit<br>
+PF03805 Cytoadherence-linked asexual protein<br>Clag (cytoadherence linked asexual gene) is a malaria surface protein which has been shown to be involved in the binding of Plasmodium falciparum infected erythrocytes to host endothelial cells, a process termed cytoadherence. The cytoadherence phenomenon is associated with the sequestration of infected erythrocytes in the blood vessels of the brain, cerebral malaria. Clag is a multi-gene family in Plasmodium falciparum with at least 9 members identified to date.  Orthologous proteins in the rodent malaria species Plasmodium chabaudi (Lawson D Unpubl. obs.) suggest that the gene family is found in other malaria species and may play a more generic role in cytoadherence.. 
+PF01217 Clathrin_adapt_s;<br>Clathrin adaptor complex small chain. 
+PF00637 Clathrin_repeat; <br>Region in Clathrin and VPS. Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.. 
+PF01086 Clathrin light chain<br>
+PF01394 Clathrin propeller repeat<br>Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles.  The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure.  Each leg contains one heavy and one light chain.  The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller  .. 
+PF03505 Clostridium enterotoxin<br>
+PF03515 Colicin-like bacteriocin tRNase domain<br>The C-terminal region of colicin-like bacteriocins is either a pore-forming or an endonuclease-like domain. Cloacin and Pyocins have similar structures and activities to the colicins from E coli and the klebicins from Klebsiella spp. Colicins E5 and D cleave the anticodon loops of distinct tRNAs of Escherichia coli both in vivo and in vitro  . The full-length molecule has an N-terminal translocation domain and a middle, double alpha-helical region which is receptor-binding  .. 
+PF03513 Cloacin immunity protein<br>
+PF01785 Closterovirus coat protein<br>Pfam-B_1309 (release 4.2) & Pfam-B_6985 (release 8.0). This family consist of coat proteins from closteroviruses a member of the closteroviridae.  The viral coat protein encapsulates and protects the viral genome. Both the large cp1 and smaller cp2 coat protein originate from the same primary transcript  .  Members of the closteroviridae include Sugar beet  yellow virus and Grapevine leafroll-associated virus,  closteroviruses have a positive strand ssRNA genome with no DNA  stage during replication. . 
+PF00574 Clp protease<br>The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111, his-136 and asp-185 form the catalytic triad. Swiss:P48254 has lost all of these active site residues and is therefore inactive. Swiss:P42379 contains two large insertions, Swiss:P42380 contains one large insertion.. 
+PF01093 Clusterin<br>
+PF03026 Influenza C virus M1 protein<br>Pfam-B_1290 (release 6.4). This family represents the matrix 1 protein of influenza C virus. The protein is the product of a spliced mRNA. Small quantities of the unspliced mRNA are found in the cell additionally encoding the M2 protein (see Pfam:PF03021).. 
+PF03021 Influenza C virus M2 protein<br>Pfam-B_1092 (release 6.4). Influenza C virus M1 protein is encoded by a spliced mRNA.  The unspliced mRNA is also found in small quantities and can encode  the protein represented by this family.. 
+PF02543 Carbamoyltransferase<br>Pfam-B_1740 (release 5.4). This family consists of NodU from Rhizobium and CmcH from Nocardia lactamdurans.  NodU a Rhizobium nodulation protein involved in the synthesis of nodulation factors has 6-O-carbamoyltransferase-like activity  .  CmcH is involved in cephamycin (antibiotic) biosynthesis and has 3-hydroxymethylcephem carbamoyltransferase activity  , EC:2.1.3.7 catalysing the reaction: Carbamoyl phosphate + 3-hydroxymethylceph-3-EM-4-carboxylate <=> phosphate + 3-carbamoyloxymethylcephem.. 
+PF04989 Cephalosporin hydroxylase<br>Members of this family are about 220 amino acids long. The CmcI protein Swiss:O85726 is presumed to represent the cephalosporin-7--hydroxylase  . However this has not been experimentally verified. . 
+PF02627 Carboxymuconolactone decarboxylase family<br>Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway  . In these bifunctional proteins (e.g. Swiss:O67982) CMD represents the C-terminal domain, Pfam:PF00561 represents the  N-terminal domain. . 
+PF00795 Nitrilase;<br>Carbon-nitrogen hydrolase. Pfam-B_1042 (release 2.1) & Pfam-B_5155 (Release 7.5). This family contains hydrolases that break carbon-nitrogen bonds  .  The family includes: Nitrilase EC:3.5.5.1 Swiss:Q42965, Aliphatic amidase EC:3.5.1.4 Swiss:Q01360, Biotidinase EC:3.5.1.12 Swiss:P43251, Beta-ureidopropionase EC:3.5.1.6 Swiss:Q03248.  Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins  .. 
+PF01110 Ciliary neurotrophic factor<br>
+PF03450 CO dehydrogenase flavoprotein C-terminal domain<br>
+PF00473 Corticotropin-releasing factor family<br>
+PF02552 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit<br>This family consists of Carbon monoxide dehydrogenase I/II beta subunit  EC:1.2.99.2 and acetyl-CoA synthase epsilon subunit.  Carbon monoxide beta subunit catalyses the reaction: CO + H2O + acceptor <=> CO2 + reduced  acceptor.. 
+PF01121 UPF0038;<br>Dephospho-CoA kinase. This family catalyses the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form Coenzyme A EC:2.7.1.24. This enzyme uses ATP in its reaction.. 
+PF02035 Coagulin<br>
+PF04733 Coatomer epsilon subunit<br>Pfam-B_3343 (release 7.5). This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex  .. 
+PF04053 Coatomer WD associated region <br>Pfam-B_1269 (release 7.3);. This region is composed of WD40 repeats.. 
+PF02572 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP<br>This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis.  These enzymes catalyse the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.. 
+PF01122 Eukaryotic cobalamin-binding protein<br>
+PF03186 CobD/Cbib protein<br>Pfam-B_2468 (release 6.5). This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein  . This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate  .. 
+PF02654 Cobalamin-5-phosphate synthase<br>This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyses the synthesis of AdoCbl-5'-p from AdoCbi-GDP  and alpha-ribazole-5'-P  .  This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop  assembly stage in conjunction with CobC, CobU and CobT  .. 
+PF02283 COBU; <br>Cobinamide kinase / cobinamide phosphate guanyltransferase. Pfam-B_7022 (release 5.2). This family is composed of a group of bifunctional cobalamin  biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape  .. 
+PF00241 cofilin_ADF; <br>Cofilin/tropomyosin-type actin-binding protein. Severs actin filaments and binds to actin monomers.. 
+PF00963 Cohesin domain<br>Cohesin domains interact with a complementary domain, termed the dockerin domain.  The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome  .. 
+PF01410 Fibrillar collagen C-terminal domain<br>Ponting CP, Schultz J, Bork P. Pfam-B_464 (release 3.0). Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.. 
+PF01024 Colicin pore forming domain<br>
+PF03857 Colicin immunity protein<br>Colicin immunity proteins are plasmid-encoded proteins necessary for protecting the cell against colicins. Colicins are toxins released by bacteria during times of stress  .. 
+PF01320 Colicin immunity protein / pyocin immunity protein<br>
+PF02674 Colicin V production protein<br>Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30  . This protein is coded for in the purF operon. . 
+PF01114 Colipase, N-terminal domain<br>SCOP reports duplication of common fold with Colipase  C-terminal domain.. 
+PF00325 crp; <br>Bacterial regulatory proteins, crp family. 
+PF02740 Colipase, C-terminal domain<br>SCOP reports duplication of common fold with Colipase  N-terminal domain.. 
+PF03047 COMC family<br>Pfam-B_2107 (release 6.4). This family consists exclusively of streptococcal competence stimulating peptide precursors, which are generally up to 50 amino acid residues long. In all the members of this family, the leader sequence is cleaved after two conserved glycine residues; thus the leader sequence is of the double- glycine type  . Competence stimulating peptides (CSP) are small (less than 25 amino acid residues) cationic peptides. The N-terminal amino acid residue is negatively charged, either glutamate or aspartate. The C-terminal end is positively charged. The third residue is also positively charged: a highly conserved arginine  . A few COMC proteins and their precursors (not included in this family) do not fully follow the above description. In particular: the leader sequence in the CSP precursor from Streptococcus sanguis NCTC 7863 Swiss:O33758 is not of the double-glycine type; the CSP from Streptococcus gordonii NCTC 3165 Swiss:O33645 does not have a negatively charged N-terminus residue and has a lysine instead of arginine at the third position.  Functionally, CSP act as pheromones, stimulating competence for genetic transformation in streptococci. In streptococci, the (CSP mediated) competence response requires exponential cell growth at a critical density, a relatively simple requirement when compared to the stationary-phase requirement of Haemophilus, or the late-logarithmic- phase of Bacillus  . All bacteria induced to competence by a particular CSP are said to belong to the same pherotype, because each CSP is recognised by a specific receptor (the signalling domain of a histidine kinase ComD). Pherotypes are not necessarily species-specific. In addition, an organism may change pherotype. There are two possible mechanisms for pherotype switching: horizontal gene transfer, and accumulation of point mutations. The biological significance of pherotypes and pherotype switching is not definitively determined. Pherotype switching occurs frequently enough in naturally competent streptococci to suggest that it may be an important contributor to genetic exchange between different bacterial species  . The family Antibacterial16, streptolysins from group A streptococci, has been merged into this family. . 
+PF02247 Large coat protein<br>Pfam-B_2294 (release 5.2). This family contains the large coat protein (LCP)   of the  comoviridae viral family.. 
+PF02248 Small coat protein<br>Pfam-B_2294 (release 5.2). This family contains the small coat protein (SCP)   of the  comoviridae viral family.. 
+PF01257 complex1_24kD; Complex1_24kDa;<br>Thioredoxin-like [2Fe-2S] ferredoxin. 
+PF00346 complex1_49Kd; <br>Respiratory-chain NADH dehydrogenase, 49 Kd subunit. 
+PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit<br>Pfam-B_780 (release 4.0). 
+PF00668 DUF4;<br>Pfam-B_130 (release 2.1). This domain is found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (Pfam:PF00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site  .. 
+PF00029 connexin; <br>
+PF03508 Gap junction alpha-1 protein (Cx43)<br>
+PF03509 Gap junction alpha-8 protein (Cx50)<br>
+PF03601 Conserved hypothetical protein 698<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03602 Conserved hypothetical protein 95<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04234 CopC domain<br>CopC is a bacterial blue copper protein that binds 1 atom of copper per  protein molecule.  Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm  .. 
+PF00127 copper-bind; <br>Copper binding proteins, plastocyanin/azurin family. 
+PF00649 Copper fist DNA binding domain<br>
+PF01218 Coproporphyrinogen III oxidase<br>
+PF03232 Ubiquinone biosynthesis protein COQ7<br>Pfam-B_3545 (release 6.5). Members of this family contain two repeats of about 90 amino acids, that contains two conserved motifs. One of these DXEXXH may be part of an enzyme active site.. 
+PF04803 Cor1/Xlr/Xmr conserved region<br>Pfam-B_6320 (release 7.5). Cor1 is a component of the chromosome core in the meiotic prophase chromosomes  .  Xlr is a lymphoid cell specific protein  . Xlm is abundantly transcribed in testis in a tissue-specific and developmentally regulated manner.\.      The protein is located in the nuclei of spermatocytes, early in the prophase of the first meiotic division, and later becomes concentrated in the XY nuclear subregion where it is in particular associated with the axes of sex chromosomes  .. 
+PF01544 CorA-like Mg2+ transporter protein<br>Pfam-B_944 (release 4.0) & Pfam-B_3206 (release 7.5). The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli.  CorA is virtually ubiquitous in the Bacteria and Archaea.  There are also eukaryotic relatives of this protein. The family includes the MRS2 protein Swiss:Q01926 from yeast that is thought to be an RNA splicing protein  .  However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.. 
+PF03311 Cornichon protein<br>Pfam-B_3813 (release 6.5). 
+PF04694 Coronavirus ORF3 protein<br>Pfam-B_5763 (release 7.5). 
+PF03262 Coronavirus 6B/7B protein<br>Pfam-B_4476 (release 6.5). 
+PF02398 Coronavirus protein 7<br>Pfam-B_1574 (release 5.4). This is a family of proteins from coronavirus which may function in  viral assembly. . 
+PF03187 Corona nucleocapsid I protein<br>Pfam-B_2926 (release 6.5). 
+PF01635 Coronavirus M matrix/glycoprotein<br>Pfam-B_845 (release 4.1). This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The M protein or E1 glycoprotein is The coronavirus M protein is implicated in virus assembly  . The E1 viral membrane protein is required for formation of the viral  envelope and is transported via the Golgi complex  .. 
+PF04753 Coronavirus non-structural protein NS2<br>Pfam-B_3747 (release 7.5). 
+PF05213 Coronavirus NS2A protein<br>Pfam-B_6568 (release 7.7). This family contains a number of corona virus non-structural proteins of unknown function. The family also includes a polymerase protein fragment from Berne virus and does not seem to be related to the Pfam:PF04753 Coronavirus NS2 family. This family is part of the 2H phosphoesterase superfamily  .. 
+PF03053 ORF3b coronavirus protein<br>Pfam-B_2130 (release 6.4). Members of this family are non-structural proteins, approximately 250 amino acid residues long. They are found in transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) isolates. These proteins are found on the same mRNA as another product, designated ORF3a. While ORF3a/b has been implicated in TGEV and PRCV pathogenesis, its precise role remains unclear (see [2,3]).. 
+PF03905 Coronavirus_NS4; <br>Coronavirus non-structural protein NS4. 
+PF00937 Coronavirus nucleocapsid protein<br>Pfam-B_267 (release 3.0). 
+PF01600 Coronavirus S1 glycoprotein<br>The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 and S2 Pfam:PF01601  .. 
+PF01601 Coronavirus S2 glycoprotein<br>The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 Pfam:PF01600 and S2  .. 
+PF00115 Cytochrome C and Quinol oxidase polypeptide I<br>Pfam-B_23 (release 1.0) and Prosite. 
+PF05051 Cytochrome C oxidase copper chaperone (COX17)<br>Moxon SJ, Mistry J, Wood V. Pfam-B_5838 (release 7.7). Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast  . The structure of Cox17   shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.. 
+PF00431 CUB domain<br>Pfam-B_136 (release 1.0). 
+PF00116 Cytochrome C oxidase subunit II, periplasmic domain<br>
+PF02790 Cytochrome C oxidase subunit II, transmembrane domain<br>The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.. 
+PF00510 Cytochrome c oxidase subunit III<br>Pfam-B_78 (release 1.0). 
+PF02284 Cytochrome c oxidase subunit Va<br>Pfam-B_7466 (release 5.2). Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit Va.. 
+PF01215 Cytochrome c oxidase subunit Vb<br>
+PF02046 Cytochrome c oxidase subunit VIa<br>
+PF02297 Cytochrome oxidase c subunit VIb<br>Pfam-B_9188 (release 5.2). Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.. 
+PF02238 Cytochrome c oxidase subunit VIIa<br>Pfam-B_3023 (release 5.2). Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the heart and liver isoforms of cytochrome c oxidase  subunit VIIa.. 
+PF02285 Cytochrome oxidase c subunit VIII<br>Pfam-B_6423 (release 5.2). Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIII.. 
+PF02672 CP12 domain<br>
+PF01383 CpcD/allophycocyanin linker domain<br>Pfam-B_887 (release 3.0). 
+PF00166 cpn10; <br>Chaperonin 10 Kd subunit. This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis  . . 
+PF05205 Cps15; <br>COMPASS (Complex proteins associated with Set1p) component shg1. The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes  .. 
+PF00289 CPSase; <br>Carbamoyl-phosphate synthase L chain, N-terminal domain. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines  . The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.. 
+PF02786 CPSase; <br>Carbamoyl-phosphate synthase L chain, ATP binding domain. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines  . The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. The ATP binding domain (this one) has an ATP-grasp fold.. 
+PF00650 CRAL/TRIO domain<br>
+PF03765 CRAL/TRIO, N-terminal domain<br>This all-alpha domain is found to the N-terminus of Pfam:PF00650.. 
+PF02537 CrcB-like protein<br>CRCB is a putative integral membrane protein possibly involved in chromosome condensation. Over expression in E. coli also leads to  camphor resistance  . . 
+PF01321 Creatinase/Prolidase N-terminal domain<br>This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.. 
+PF00030 crystall; <br>Beta/Gamma crystallin. Swissprot_feature_table. The alignment comprises two Greek key motifs since the similarity between them is very low.. 
+PF02633 Creatinine amidohydrolase<br>Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyses  the hydrolysis of creatinine to creatine  . . 
+PF03858 Crustacean neurohormone H<br>These proteins are referred to as precursor-related peptides as they are typically co-transcribed and translated with the CHH neurohormone (Pfam:PF01147).  However, in some species this neuropeptide is synthesised as a separate protein. Furthermore, neurohormone H can undergo proteolysis to give rise to 5 different neuropeptides  .  . 
+PF01147 Crustacean CHH/MIH/GIH neurohormone family<br>
+PF00525 crystallin; <br>Alpha crystallin A chain, N terminal. Pfam-B_97 (release 1.0). 
+PF03783 Curli production assembly/transport component CsgG<br>CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB  .. 
+PF02599 Global regulator protein family<br>This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay  .  In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis  . In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes  . RmsA binds to RmsB regulatory RNA.. 
+PF02554 Carbon starvation protein CstA<br>This family consists of Carbon starvation protein CstA a predicted membrane protein.\.   It has been suggested that CstA is involved in peptide utilisation  .. 
+PF00859 CTF/NF-I family transcription modulation region<br>Pfam-B_362 (release 3.0). 
+PF01467 Cytidylyltransf; <br>Cytidylyltransferase. This family includes: Cholinephosphate cytidylyltransferase Swiss:P49585. Glycerol-3-phosphate cytidylyltransferase Swiss:P27623.. 
+PF02348 Cytidylyl_trans; <br>Cytidylyltransferase. Pfam-B_886 (release 5.2). This family consists of two main Cytidylyltransferase activities: 1) 3-deoxy-manno-octulosonate cytidylyltransferase,  , EC:2.7.7.38 catalysing the reaction:- CTP + 3-deoxy-D-manno-octulosonate <=> diphosphate + CMP-3-deoxy-D-manno-octulosonate, 2) acylneuraminate cytidylyltransferase EC:2.7.7.43, [1,2], catalysing  the reaction:- CTP + N-acylneuraminate <=> diphosphate + CMP-N-acylneuraminate. NeuAc cytydilyltransferase of Mannheimia haemolytica has been characterised describing kinetics and regulation by substrate charge, energetic charge and amino-sugar demand .. 
+PF04808 Citrus tristeza virus (CTV) P23 protein <br>Pfam-B_2595 (release 7.6). This family consists of protein P23 from the citrus tristeza virus, which is a member of the Closteroviridae.\.  CTV viruses produce more positive than negative RNA strands, and P23 controls this asymmetrical RNA accumulation. Amino acids 42-180 are essential for function and are thought to contain RNA-binding and zinc finger domains  .. 
+PF01179 Copper amine oxidase, enzyme domain<br>Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ). This family corresponds to the catalytic domain of the enzyme. . 
+PF02727 Copper amine oxidase, N2 domain<br>This domain is the first or second structural domain in copper amine oxidases, it is known as the N2 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).. 
+PF02728 Copper amine oxidase, N3 domain<br>This domain is the second or third structural domain in copper amine oxidases, it is known as the N3 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).. 
+PF02298 Plastocyanin-like domain<br>Pfam-B_398 (release 5.2). This family represents a domain found in flowering plants related to the copper binding protein plastocyanin. Some members of this family (eg  Swiss:P93328) may not bind copper due to the lack of key residues.. 
+PF03263 Cucumovirus protein 2B<br>Pfam-B_4373 (release 6.5). This protein may be a viral movement protein.. 
+PF00760 Cucumovirus coat protein<br>Pfam-B_867 (release 2.1). 
+PF02376 CUT domain<br>Pfam-B_770 (release 5.2). The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein (eg Swiss:P10180).. 
+PF00888 Cullin family<br>Pfam-B_1149 (release 3.0). 
+PF03091 CutA1 divalent ion tolerance protein<br>Pfam-B_2307 (release 6.4). Several gene loci with a possible involvement in cellular tolerance to copper have been identified  . One such locus in eubacteria and  archaebacteria, cutA, is thought to be  involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognised structural motifs  . This family also contains putative proteins from eukaryotes (human and Drosophila).. 
+PF03932 CutC family<br>Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.. 
+PF01083 Cutinase<br>
+PF01473 Putative cell wall binding repeat<br>These repeats are characterised by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins.  The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls  . Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding   as well as in the related dextransucrases of Leuconostoc mesenteroides.  Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known.. 
+PF04122 Putative cell wall binding repeat 2<br>This repeat is found in multiple tandem copies in proteins including  amidase enhancers   and adhesins  .. 
+PF03638 CXC;<br>Tesmin/TSO1-like CXC domain, cysteine-rich domain. Pfam-B_1144 (release 7.0). This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin Swiss:Q9Y4I5   and TSO1 Swiss:Q9LE32  . This family is called a CXC domain in  .. 
+PF03128 CXCXC repeat<br>Pfam-B_252 (release 6.5). This repeat contains the conserved pattern CXCXC where X can be any amino acid.  The repeat is found in up to five copies in Vascular endothelial growth factor C  . In the salivary glands of the dipteran Chironomus tentans, a specific messenger ribonucleoprotein (mRNP) particle, the Balbiani ring (BR) granule, can be visualised during its assembly on the gene and during its nucleocytoplasmic transport. This repeat is found over 70 copies in the balbiani ring protein 3 Swiss:Q03376. It is also found in some silk proteins  .. 
+PF02560 Cyanate lyase C-terminal domain<br>Cyanate lyase (also known as cyanase) EC:4.2.1.104 is responsible for the hydrolysis of cyanate, allowing organisms that possess the enzyme to overcome the toxicity of environmental cyanate. This enzyme is composed of two domains, an N-terminal helix-turn-helix and this structurally unique C-terminal domain  .. 
+PF04199 Putative cyclase<br>Pfam-B_1440 (release 7.3). Proteins in this family are thought to be cyclase enzymes.  They are found in proteins involved in antibiotic synthesis.  However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.. 
+PF02984 cyclin_C; <br>Cyclin, C-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins  . Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.. 
+PF03784 Cyclotide family<br>This family contains a set of cyclic peptides with a variety of activities. The structure consists of a distorted triple-stranded beta-sheet and a cysteine-knot arrangement of the disulfide bonds  . Cyclotides can be separated into two subfamilies, namely bracelet and moebius. The bracelet cyclotide subfamily tends to contain a larger number of positively charged residues and has a bracelet-like circularisation of the backbone  . The moebius cyclotide subfamily contains a backbone twist due to a cis-Pro peptide bond and may conceptually be regarded as a molecular Moebius strip  .. 
+PF00548 Cys-protease-3C; <br>3C cysteine protease (picornain 3C). Picornaviral proteins are expressed as a single polyprotein which is cleaved by the viral 3C cysteine protease.. 
+PF00007 Cystine-knot domain<br>Published_alignment enriched with PDOC00234 members.. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins.  It is believed to be involved in disulfide-linked dimerisation.. 
+PF01053 Cys/Met metabolism PLP-dependent enzyme<br>Pfam-B_366 (release 3.0). This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase,  O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.. 
+PF00839 cys_rich_FGFR; <br>Cysteine rich repeat. Pfam-B_297 (release 3.0). This cysteine rich repeat contains four cysteines.  It is found in multiple copies in a protein that binds to fibroblast growth factors  . The repeat is also found in MG160 and E-selectin ligand (ESL-1).. 
+PF00031 cystatin; <br>Very diverse family.  Attempts to define separate sub-families failed.  Typically, either the N-terminal or C-terminal end is very divergent.  But splitting into two domains would make very short families. All members except Swiss:Q03196 and Swiss:Q10993 are found. Pfam:PF00666 are related to this family but have not been included.. 
+PF01578 CytC_asm; <br>Cytochrome C assembly protein. Pfam-B_114 (release 4.1) Pfam-B_8014 (Release 8.0). This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium ,  CcmC from E. coli and Paracoccus denitrificans [2,1] and orf240 from wheat mitochondria  .  The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an  ABC (ATP binding cassette) transporter complex. It is also proposed  that this transporter is necessary for transport of some component  needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif  , orf240 also contains a putative heme-binding motif and is a proposed  ABC transporter with c-type heme as its proposed substrate  . However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither  .. 
+PF02224 Cytidylate kinase<br>Pfam-B_1582 (release 5.2). Cytidylate kinase EC:2.7.4.14 catalyses the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.. 
+PF01265 Cytochrome c/c1 heme lyase<br>
+PF02322 Cytochrome oxidase subunit II<br>Pfam-B_997 (release 5.2). This Family consists of cytochrome bd type terminal oxidases that catalyses Quinol dependent, Na+ independent oxygen uptake  .  Members of this family are integral membrane proteins andi  contain a protohaem IX centre B558. One member of the family  Swiss:O05192 is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella  pneumoniae  .. 
+PF00283 cytochr_b559; <br>Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits. 
+PF00284 cytochr_b559a; <br>Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit. This family is the lumenal portion of cytochrome b559 alpha chain, matches to this family should be accompanied by a match to the Pfam:PF00283 family also. The Prosite pattern pattern matches the transmembrane region of the cytochrome b559 alpha and beta subunits.. 
+PF02335 cytochr_c552; <br>Pfam-B_19175 (release 5.2). Cytochrome c552 (cytochrome c nitrite reductase) is a crucial enzyme  in the nitrogen cycle catalysing the reduction of nitrite to ammonia. The crystal structure of cytochrome c552 reveals it to be a dimer, with with 10 close-packed type c haem groups.. 
+PF03188 Cytochrome_B561; <br>Eukaryotic cytochrome b561. Pfam-B_2927 (release 6.5) & Pfam-B_7165 (Release 8.0). Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.. 
+PF00032 cytochrome_b_C; <br>Cytochrome b(C-terminal)/b6/petD. 
+PF00033 cytochrome_b_N; <br>Cytochrome b(N-terminal)/b6/petB. 
+PF00034 cytochrome_c; <br>The Pfam entry does not include all Prosite members.  The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, Pfam:PF06181, has now been merged into this family.. 
+PF02167 Cytochrome_C1; <br>Cytochrome C1 family. 
+PF01322 Cytochrome_C_2; <br>
+PF02085 Cytochrome_CIII; <br>Class III cytochrome C family. 
+PF03264 Cytochrome_NNT; <br>NapC/NirT cytochrome c family, N-terminal region. Pfam-B_1404 (release 6.5). Within the NapC/NirT family of cytochrome c proteins, some members, such as NapC Swiss:P33932 and NirT Swiss:P24038, bind four haem groups, while others, such as TorC Swiss:P33226, bind five haems. This family aligns the common N-terminal region that contains four haem-binding C-X(2)-CH motifs.. 
+PF01801 Cytomegalo_gL; <br>Cytomegalovirus glycoprotein L . Pfam-B_1420 (release 4.2). Glycoprotein L from cytomegalovirus serves a chaperone for the correct folding and surface expression of glycoprotein H  (gH)  . Glycoprotein L is a member of the heterotrimeric gCIII complex of  glycoprotein which also includes gH and gO and has an essential  role in viral fusion  .. 
+PF02239 D1_heme; <br>Cytochrome D1 heme domain. Pfam-B_3322 (release 5.2). Cytochrome cd1 (nitrite reductase) catalyses the conversion of  nitrite to nitric oxide in the nitrogen cycle. This family represents the d1 heme binding domain of cytochrome cd1, in which His/Tyr side  chains ligate the d1 heme iron of the active site in the oxidised  state  .. 
+PF02109 DAD family<br>Members of this family are thought to be integral membrane proteins.  Some members of this family have been shown to cause apoptosis if mutated  , these proteins are known as DAD for defender against death.  The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation  .. 
+PF00130 DAG_PE-bind; C1;<br>Phorbol esters/diacylglycerol binding domain (C1 domain). This domain is also known as the Protein kinase C conserved region 1 (C1) domain.. 
+PF03982 Diacylglycerol acyltransferase <br>Pfam-B_11378 (release 7.2). The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT) [1,2].. 
+PF01219 Prokaryotic diacylglycerol kinase<br>
+PF00609 DAGKa; <br>Diacylglycerol kinase accessory domain. Ponting C, Schultz J, Bork P. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.. 
+PF00781 DAGKc; <br>Diacylglycerol kinase catalytic domain. Alignment kindly provided by SMART. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family  .. 
+PF00793 DAHP_synthetase;<br>DAHP synthetase I family. Pfam-B_1032 (release 2.1). Members of this family catalyse the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.. 
+PF01474 Class-II DAHP synthetase family<br>Prodom_1974 (release 99.1). Members of this family are aldolase enzymes that catalyse the first step of the shikimate pathway.. 
+PF02733 Dak1 domain<br>This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29. . 
+PF02734 DAK2 domain<br>This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.. 
+PF03045 DAN domain<br>Pfam-B_1968 (release 6.4). This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges.  This family of proteins has been termed the DAN family   after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling.  It is postulated that all members of this family antagonise different TGF beta Pfam:PF00019 ligands  . Recent work shows that the DAN protein is not an efficient antagonist of  BMP-2/4 class signals, we found that DAN was able to interact with  GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo  .. 
+PF01266 FAD dependent oxidoreductase<br>This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.. 
+PF01678 Diaminopimelate epimerase<br>Pfam-B_2089 (release 4.1). Diaminopimelate epimerase contains two domains of the same alpha/beta fold, both contained in this family.. 
+PF05173 Dihydrodipicolinate reductase, C-terminus<br>Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate.  This  reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The C-terminal domain of DapB has been proposed to be the substrate- binding domain.. 
+PF03344 Daxx Family<br>Pfam-B_3933 (release 6.5). The Daxx protein (also known as the Fas-binding protein) is thought  to play a role in apoptosis, but precise role played by Daxx remains to be determined. Daxx forms a complex with Axin. . 
+PF02277 Phosphoribosyltransferase<br>Pfam-B_5739 (release 5.2). This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin  .. 
+PF03880 YxiN_DEAD; <br>DbpA RNA binding domain   . This RNA binding domain is found at the C-terminus of a number of DEAD helicase proteins  .  It is sufficient to confer specificity  for hairpin 92 of 23S rRNA, which is part of the ribosomal A-site. However, several members of this family lack specificity for 23S rRNA. These can proteins can generally be distinguished by a basic region that extends beyond this domain [Karl Kossen, unpublished data].. 
+PF04290 Tripartite ATP-independent periplasmic transporters, DctQ component<br>The function of the members of this family is unknown, but DctQ homologues are invariably found in the tripartite ATP-independent periplasmic transporters  . . 
+PF03605 Dcu; <br>Anaerobic c4-dicarboxylate membrane transporter. TIGRFAMs, Griffiths-Jones SR. 
+PF03606 C4-dicarboxylate anaerobic carrier<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03184 CENP-B; DDE;<br>DDE superfamily endonuclease. Pfam-B_2254 (release 6.5). This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localised to the centromere.. 
+PF02862 DDHD domain<br>The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues.  This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3)  . This suggests that this region is involved in functionally important interactions in other members of this family.. 
+PF03345 Oligosaccharyltransferase 48 kDa subunit beta<br>Pfam-B_3520 (release 6.5). Members of this family are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST), also known as oligosaccharyltransferase EC:2.4.1.119, transfers the high-mannose sugar GlcNAc(2)-Man(9)-Glc(3) from a dolichol-linked donor to an asparagine acceptor in a consensus Asn-X-Ser/Thr motif. In most eukaryotes, the DDOST complex is composed of three subunits, which in humans are described as a 48kD subunit, ribophorin I, and ribophorin II. However, the yeast DDOST appears to consist of six subunits (alpha, beta, gamma, delta, epsilon, zeta). The yeast beta subunit is a 45kD polypeptide, previously discovered as the Wbp1 protein, with known sequence similarity to the human 48kD subunit and the other orthologues. This family includes the 48kD-like subunits from several eukaryotes; it also includes the yeast DDOST beta subunit Wbp1.. 
+PF04625 DEC-1 protein, N-terminal region<br>The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing  .  Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa).. 
+PF04624 DEC-1_REPEAT;<br>The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing  . Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). This repeat is usually found in 12 copies in the central region of the protein. Its function is unknown.  Length polymorphisms of Dec-1 have been observed in wild-type strains, and are caused by changes in the numbers of the first five repeats  .. 
+PF02352 Decorin binding protein<br>Pfam-B_800 (release 5.2). This family consists of decorin binding proteins from Borrelia.  The decorin binding protein of Borrelia  burgdorferi the lyme disease spirochetes adheres to the  proteoglycan decorin found on collagen fibres  .. 
+PF01335 Death effector domain<br>
+PF00711 Beta defensin<br>Pfam-B_675 (release 2.1). The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation  .. 
+PF00879 Defensin propeptide<br>Pfam-B_517 (release 3.0). 
+PF00323 defensins; <br>
+PF01041 DegT_DnrJ_EryC1_fam;<br>DegT/DnrJ/EryC1/StrS aminotransferase family. Pfam-B_239 (release 3.0). The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA Swiss:P72454, StsC Swiss:P77952  and StsS  . The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyses the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin  .. 
+PF02286 Dehydratase large subunit<br>Pfam-B_7927 (release 5.2). This family contains the large subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.. 
+PF02288 Dehydratase medium subunit<br>Pfam-B_7081 (release 5.2). This family contains the medium subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.. 
+PF02287 Dehydratase small subunit<br>Pfam-B_6588 (release 5.2). This family contains the small subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.. 
+PF00257 dehydrin; <br>Prosite & Pfam-B_3306 (Release 7.5). 
+PF02336 denso_VP4; <br>Pfam-B_19701 (release 5.2). Four different translation initiation sites of the densovirus capsid protein mRNA give rise to four viral  proteins, VP1 to VP4. This family represents VP4.. 
+PF01791 DeoC/LacD family aldolase<br>This family includes diverse aldolase enzymes.  This family includes the enzyme deoxyribose-phosphate aldolase EC:4.1.2.4, which is involved in nucleotide metabolism. The family also includes a group of related bacterial proteins of unknown function, see examples Swiss:Q57843 and Swiss:P76143.  The family also includes tagatose 1,6-diphosphate aldolase (EC:4.1.2.40) is part of the tagatose-6-phosphate pathway of galactose-6-phosphate degradation  .. 
+PF00455 deoR; DeoR;<br>DeoR C terminal sensor domain. The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site  . DeorC  senses diverse sugar derivatives such as deoxyribose nucleoside  (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR)  ,  ,  .. 
+PF04511 Der1-like family<br>Pfam-B_1901 (release 7.5). 
+PF01880 Desulfoferrodoxin<br>Desulfoferrodoxins contains two types of iron: an Fe-S4 site very similar to that found in desulforedoxin from Desulfovibrio gigas and an octahedral coordinated high-spin ferrous site most probably with nitrogen/oxygen-containing ligands. Due to this rather unusual combination of active centres, this novel protein is named desulfoferrodoxin  .. 
+PF04598 DFNA5; <br>Pfam-B_5153 (release 7.5). The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form  . In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells  . This family also includes the gasdermin protein  . 
+PF04127 dfp;<br>DNA / pantothenate metabolism flavoprotein. Pfam-B_6559 (release 7.3);. The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.. 
+PF05035 2-keto-3-deoxy-galactonokinase<br>2-keto-3-deoxy-galactonokinase EC:2.7.1.58 catalyses the second step in D-galactonate degradation.. 
+PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase<br>Pfam-B_1148 (release 3.0). 
+PF00701 Dihydrodipicolinate synthetase family<br>Pfam-B_557 (release 2.1). This family has a TIM barrel structure.. 
+PF01368 DHH family<br>Pfam-B_1245 (release 3.0). It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ.. 
+PF02833 DHHA2 domain<br>This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members  . The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.. 
+PF01180 DHOdehase; <br>Dihydroorotate dehydrogenase. 
+PF01761 3-dehydroquinate synthase<br>Pfam-B_1327 (release 4.2). The 3-dehydroquinate synthase EC:4.6.1.3 domain is present in isolation in various bacterial 3-dehydroquinate  synthases and also present as a domain in the pentafunctional AROM polypeptide Swiss:P07547  . 3-dehydroquinate (DHQ) synthase catalyses the formation of  dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate  . This reaction is part of the shikimate pathway which is involved  in the biosynthesis of aromatic amino acids.  . 
+PF01487 Type I 3-dehydroquinase<br>Pfam-B_2492 (release 4.0). Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Type II 3-dehydroquinase catalyses the trans-dehydration of 3-dehydroshikimate see Pfam:PF01220.. 
+PF01220 Dehydroquinase class II<br>
+PF04706 dickkopf_N; <br>Dickkopf N-terminal cysteine-rich region. Pfam-B_5838 (release 7.5). Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one  . The C-terminal region has been found to share significant sequence similarity to the colipase fold, Pfam:PF01114, Pfam:PF02740  .. 
+PF05086 Dict_REP; <br>Dictyostelium (Slime Mold) REP protein. Pfam-B_6278 (release 7.7). This family consists of REP proteins from Dictyostelium (Slime molds). REP protein is likely involved in transcription regulation and control of DNA replication, specifically amplification of plasmid at low copy numbers. The formation of homomultimers may be required for their regulatory activity  .. 
+PF04562 Dict_spore_N;<br>Dictyostelium spore coat protein, N terminus. The Dictyostelium spore coat is a polarised extracellular matrix composed of glycoproteins and cellulose. Four of the major coat glycoproteins exist as a multi-protein complex within the prespore vesicles before secretion.  Of these, SP96 and SP70 are members of this family. The presence of SP96 and SP70 in the complex is necessary for the cellulose binding activity of the complex, which is in turn necessary for normal spore coat assembly  . The function of this region of these proteins is not known.. 
+PF00186 DiHfolate_red; <br>Dihydrofolate reductase. 
+PF02966 Mitosis protein DIM1<br>
+PF05163 DinB family<br>DNA damage-inducible (din) genes in Bacillus subtilis are coordinately regulated and together compose a global regulatory network that has been termed the SOS-like or SOB regulon. This family includes DinB from B. subtilis  .. 
+PF00775 Dioxygenase; <br>Pfam-B_1018 (release 2.1). 
+PF04444 Catechol dioxygenase N terminus<br>This family consists of the N termini of catechol, chlorocatechol or  hydroxyquinol 1,2-dioxygenase proteins.  This region is always found  adjacent to the dioxygenase domain (Pfam:PF00775).. 
+PF01866 Putative diphthamide synthesis protein<br>Swiss:Q16439 is a candidate tumour suppressor gene  . DPH2 from yeast Swiss:P32461  , which confers resistance to diphtheria toxin has been found to be involved in diphthamide synthesis. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in EF2.  The exact function of the members of this family is unknown.. 
+PF02763 Diphtheria toxin, C domain<br>N-terminal catalytic (C) domain - blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of EF-2.. 
+PF01324 Diphtheria_tox; <br>Diphtheria toxin, R domain. C-terminal receptor binding (R) domain - binds to cell surface receptor, permitting the toxin to enter the cell by receptor  mediated endocytosis.. 
+PF02764 Diphtheria toxin, T domain<br>Central domain of diphtheria toxin is the translocation (T) domain.   pH induced conformational change in this domain triggers insertion  into the endosomal membrane and facilitates the transfer of the  catalytic domain into the cytoplasm.. 
+PF00200 disintegrin; <br>
+PF05141 Pyoverdine/dityrosine biosynthesis protein<br>DIT1 is involved in synthesising dityrosine  . Dityrosine is a sporulation-specific component of the yeast ascospore wall that is essential for the resistance of the spores to adverse environmental conditions. Pyoverdine biosynthesis protein PvcA is involved in the biosynthesis of pyoverdine, a cyclized isocyano derivative of tyrosine [2,3]. It has a modified Rossmann fold  .. 
+PF04977 Septum formation initiator<br>DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation  . These proteins are mainly composed of an amino terminal coiled-coil.. 
+PF05103 DivIVA protein<br>The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells  . Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype  . These proteins appear to contain coiled-coils.. 
+PF00778 DAX; <br>Alignment kindly provided by SMART. The DIX domain is present in Dishevelled and axin  . This domain is involved in homo- and hetero-oligomerisation. It is involved in the homo- oligomerisation of mouse axin Swiss:O35625  . The axin DIX domain also interacts with the dishevelled DIX domain  .  The DIX domain has also been called the DAX domain.. 
+PF01738 Dienelactone hydrolase family<br>Pfam-B_757 (release 4.2). 
+PF04914 DltD C-terminal region<br>Pfam-B_6216 (release 7.6). DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.   It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis  . This family consists of the C-terminal region of DltD.. 
+PF04918 DltD_central; <br>Pfam-B_6216 (release 7.6). DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.   It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis  . This family consists of the central region of DltD.. 
+PF04915 DltD N-terminal region<br>Pfam-B_6216 (release 7.6). DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.  It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis  . This family consists of the N-terminal region of DltD.. 
+PF03474 DMRTA motif<br>This region is found to the C-terminus of the Pfam:PF00751  . DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown.. 
+PF00885 6,7-dimethyl-8-ribityllumazine synthase<br>Pfam-B_1503 (release 3.0). This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example Swiss:O28856.. 
+PF04976 DMSO reductase anchor subunit (DmsC)<br>The terminal electron transfer enzyme Me2SO reductase of Escherichia coli is a heterotrimeric enzyme composed of a membrane extrinsic catalytic dimer (DmsAB) and a membrane intrinsic polytopic anchor subunit (DmsC)  .. 
+PF03989 DNA gyrase C-terminal domain, beta-propeller<br>This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a  beta-propeller structure  . This region has been shown to bind DNA non-specifically and may stabilise the DNA-topoisomerase complex  .. 
+PF00204 DNA_topoisoII; <br>This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold.  This family is structurally related to PF01119.. 
+PF00986 DNA gyrase B subunit, carboxyl terminus<br>Pfam-B_332 (release 3.0). The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B  protein is thought to catalyse the ATP-dependent super-coiling of  DNA. See Pfam:PF00204. The carboxyl-terminal end supports the  complexation with the DNA gyrase A protein and the ATP-independent  relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase,  .. 
+PF03603 DNA polymerase III psi subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01653 DNA_ligase_N; <br>NAD-dependent DNA ligase adenylation domain. Pfam-B_1334 (release 4.1). DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor  . This domain is the catalytic adenylation domain.  The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism  .. 
+PF03120 NAD-dependent DNA ligase OB-fold domain<br>Pfam-B_1334 (release 4.1). DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor  . This family is a small domain found after the adenylation domain Pfam:PF01653 in NAD dependent ligases  . OB-fold domains generally are involved in nucleic acid binding. . 
+PF03119 NAD-dependent DNA ligase C4 zinc finger domain<br>Pfam-B_1334 (release 4.1). DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor  . This family is a small zinc binding motif that is presumably DNA binding  . IT is found only in NAD dependent DNA ligases  .. 
+PF00145 C-5 cytosine-specific DNA methylase<br>
+PF01119 DNA mismatch repair protein, C-terminal domain<br>This family represents the C-terminal domain of the  mutL/hexB/PMS1 family.  This domain has a ribosomal S5  domain 2-like fold.. 
+PF02499 Probable DNA packing protein, C-terminus<br>Pfam-B_1283 (release 5.4). This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is found at the C-terminus of the protein.. 
+PF02500 Probable DNA packing protein, N-terminus <br>Pfam-B_1179 (release 5.4). This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is normally found at the N-terminus of the protein.. 
+PF00712 DNA polymerase III beta subunit, N-terminal domain<br>Pfam-B_631 (release 2.1). A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.. 
+PF02767 DNA polymerase III beta subunit, central domain<br>Pfam-B_631 (release 2.1). A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.. 
+PF02768 DNA polymerase III beta subunit, C-terminal domain<br>Pfam-B_631 (release 2.1). A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.. 
+PF04364 DNA polymerase III chi subunit, HolC<br>The DNA polymerase III holoenzyme (EC:2.7.7.7) is the polymerase responsible for the replication of the Escherichia coli chromosome.  The holoenzyme is composed of the DNA polymerase III core, the sliding clamp, and the DnaX clamp loading complex. The DnaX complex contains either either the tau or gamma product of gene dnax, complexed to delta.delta' and to chi psi. Chi forms a 1:1 heterodimer with psi.\. The chi psi complex functions by increasing the affinity of tau and gamma for delta.delta' allowing a functional clamp-loading complex to form at physiological subunit concentrations.  Psi is responsible for the interaction with DnaX (gamma/tau), but psi is insoluble unless it is in a complex with chi  .. 
+PF00476 DNA polymerase family A<br>
+PF03175 DNA polymerase type B, organellar and viral<br>Pfam-B_236 (release 6.5). Like Pfam:PF00136, members of this family are also DNA polymerase type B proteins. Those included here are found in plant and fungal mitochondria, and in viruses.. 
+PF04042 DNA polymerase alpha/epsilon subunit B<br>Pfam-B_12632 (release 7.3) and Pfam-B_5821 (release 7.3). This family contains a number of DNA polymerase subunits.\.      The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner.  DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast.  The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18.  Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure  .. 
+PF04931 DNA_pol_V; <br>Pfam-B_10566 (release 7.6). This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localised exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.. 
+PF00336 DNA polymerase (viral) C-terminal domain<br>Pfam-B_107 (release 1.0). 
+PF00242 DNA polymerase (viral) N-terminal domain<br>Pfam-B_107 (release 1.0). 
+PF04104 Eukaryotic and archaeal DNA primase, large subunit<br>DNA primase is the polymerase that synthesises small RNA primers for the Okazaki fragments made during discontinuous DNA replication.  DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae)  .  The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase  .. 
+PF01896 Eukaryotic and archaeal DNA primase small subunit<br>DNA primase synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. DNA primase is a heterodimer of large and small subunits.  This family also includes baculovirus late expression factor 1 or LEF-1 proteins. Baculovirus LEF-1 is a DNA primase enzyme  .  Bacterial DNA primase adopts a different fold to archaeal and eukaryotic primases.. 
+PF03604 DNA directed RNA polymerase, 7 kDa subunit<br>
+PF00521 DNA gyrase/topoisomerase IV, subunit A<br>Pfam-B_55 (release 1.0). 
+PF01556 DnaJ_C;<br>DnaJ C terminal domain. Pfam-B_342 (release 4.0). This family consists of the C terminal region form the DnaJ protein.  It is always found associated with Pfam:PF00226 and Pfam:PF00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and this, CTDII, are necessary for maintaining the J-domains in their specific relative positions  .. 
+PF00684 DnaJ central domain<br>Pfam-B_89 (release 2.1). The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc.  Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found  .. 
+PF03265 Deoxyribonuclease II<br>Pfam-B_4508 (release 6.5). 
+PF01712 Deoxynucleoside kinase<br>Pfam-B_1744 (release 4.1). This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76  and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine  and deoxycytosine.) These enzymes catalyse the production of  deoxynucleotide 5'-monophosphate from a deoxynucleoside.  Using ATP and yielding ADP in the process.. 
+PF00404 celCC;<br>Dockerin type I repeat. The dockerin repeat is the binding partner of the cohesin domain Pfam:PF00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome  . The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium  .. 
+PF04118 Dopey, N-terminal<br>Pfam-B_17466 (release 7.3);. DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organisation of multicellular structures  in the filamentous fungus Aspergillus nidulans. DopA homologues are found in mammals.  S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis  .. 
+PF04556 DpmII;<br>DpnII restriction endonuclease. Members of this family are type II restriction enzymes (EC:3.1.21.4).  They recognise the double-stranded unmethylated sequence GATC and cleave before G-1  . http://rebase.neb.com/rebase/enz/DpnII.html. 
+PF04244 DUF426; <br>Deoxyribodipyrimidine photo-lyase-related protein. This family appears to be related to Pfam:PF00875.. 
+PF05219 DREV methyltransferase<br>Pfam-B_6662 (release 7.7). 
+PF02635 DsrE/DsrF-like family<br>DsrE is a small soluble protein involved in intracellular sulfur  reduction  . This family also includes DsrF.. 
+PF01916 Deoxyhypusine synthase<br>Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation  .. 
+PF01323 DSBA-like thioredoxin domain<br>This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways [2,3,4].  This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. Swiss:P24473), whose similarity to HCCA isomerases was not previously recognised.  The sequence Swiss:O07298 has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence Swiss:Q9ZI67 has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum Swiss:Q52782 protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see  ).. 
+PF02600 Disulfide bond formation protein DsbB<br>This family consists of disulfide bond formation protein DsbB from bacteria.\.   The DsbB protein oxidises the periplasmic protein DsbA which in turn oxidises cysteines in other periplasmic proteins in order to make disulfide bonds  .  DsbB acts as a redox potential transducer across the cytoplasmic membrane and is an integral membrane protein  . DsbB posses six cysteines four of which are necessary for it proper function in vivo  .. 
+PF02683 Cytochrome C biogenesis protein transmembrane region<br>This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange  proteins.  These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.. 
+PF01984 DUF122; <br>Double-stranded DNA-binding domain. This domain is believed to bind double-stranded DNA   of 20 bases length.. 
+PF04077 DsrH like protein<br>DsrH  is involved in oxidation of intracellular sulphur in the phototrophic sulphur bacterium Chromatium vinosum D  .. 
+PF05160 DSS1/SEM1 family<br>Pfam-B_22209 (release 7.7). This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homologue SEM1, both of which are short acidic proteins.  DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe  .. 
+PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase<br>Pfam-B_540 (release 3.0). This family catalyse the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.. 
+PF03942 DTW domain<br>This presumed domain is found in bacterial and eukaryotic proteins.  Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.. 
+PF01950 DUF100; <br>Fructose-1,6-bisphosphatase. This is a family of bacterial and archaeal fructose-1,6-bisphosphatases (FBPases).  FBPase catalyses the hydrolysis of D-fructose-1,6-bisphosphate (FBP) to D-fructose-6-phosphate (F6P) and orthophosphate and is an essential regulatory enzyme in the glyconeogenic pathway.. 
+PF01954 Protein of unknown function DUF104<br>This family includes short archaebacterial proteins of unknown function.\.       Archaeoglobus fulgidus has twelve copies of this protein, with several being clustered together in the genome.. 
+PF01955 DUF105; <br>Adenosylcobinamide amidohydrolase. This prokaryotic protein family includes CbiZ which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route  .. 
+PF01956 DUF106; Methyltrn_RNA_3;<br>Integral membrane protein DUF106. This archaebacterial protein family has no known function. Members are predicted to be integral membrane proteins.. 
+PF01957 DUF107; <br>NfeD-like C-terminal, partner-binding. NfeD-like proteins are widely distributed throughout prokaryotes and are frequently associated with genes encoding stomatin-like proteins (slipins). There appear to be three major groups: an ancestral group with only an N-terminal serine protease domain and this C-terminal beta sheet-rich domain which is structurally very similar to the OB-fold domain, associated with its neighbouring slipin cluster; a second major group with an additional middle, membrane-spanning domain, associated in some species with eoslipin and in others with yqfA; a final 'artificial' group which unites truncated forms lacking the protease region and associated with their ancestral gene partner, either yqfA or eoslipin. This NefD, C-terminal, domain appears to be the major one for relating to the associated protein. NfeD homologues are clearly reliant on their conserved gene neighbour which is assumed to be necessary for function, either through direct physical interaction or by functioning in the same pathway, possibly involve with lipid-rafts  .. 
+PF01958 Domain of unknown function DUF108<br>This family has no known function.  It is found to compose the complete protein in archaebacteria and a single domain in a large C. elegans protein Swiss:Q19527.. 
+PF01959 DUF109; <br>3-dehydroquinate synthase (EC 4.6.1.3). 3-Dehydroquinate synthase is an enzyme in the common pathway of aromatic amino acid biosynthesis that catalyses the conversion of  3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) into 3-dehydroquinic acid  . This synthesis of aromatic amino acids is an essential metabolic function for most prokaryotic as well as lower eukaryotic cells, including plants. The pathway is absent in humans; therefore, DHQS represents a potential target for the development of novel and selective antimicrobial agents. Owing to the threat posed by the spread of pathogenic bacteria resistant to many currently used antimicrobial drugs, there is clearly a need to develop new anti-infective drugs acting at novel targets. A further potential use for DHQS inhibitors is as herbicides  .. 
+PF01345 Domain of unknown function DUF11<br>Pfam-B_1553 (release 3.0). A domain of unknown function found in multiple copies in several archaebacterial proteins.. 
+PF01969 Protein of unknown function DUF111<br>This prokaryotic family has no known function.. 
+PF01970 DUF112;<br>Tripartite tricarboxylate transporter TctA family. This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families  . TctA is part of the tripartite TctABC system which, as characterised in S. typhimurium  , is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules  .. 
+PF01972 DUF114;<br>Serine dehydrogenase proteinase. This family of archaebacterial proteins, formerly known as DUF114, has been found to be a serine dehydrogenase proteinase distantly related to ClpP proteinases that belong to the serine proteinase superfamily. The family has a catalytic triad of Ser, Asp, His residues, which shows an altered residue ordering compared with the ClpP proteinases but similar to that of the carboxypeptidase clan  .. 
+PF01973 DUF115;<br>Protein of unknown function DUF115. This family of archaebacterial proteins has no known function.. 
+PF01976 Protein of unknown function DUF116<br>This archaebacterial protein has no known function. The protein contains seven conserved cysteines and may also be an integral membrane protein.. 
+PF01978 DUF118; <br>Sugar-specific transcriptional regulator TrmB. One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter   in Thermococcus litoralis.. 
+PF01982 DUF120; <br>Domain of unknown function DUF120. This domain is a CTP-dependent riboflavin kinase (RFK), found in archaea, that catalyses the phosphorylation of riboflavin to form flavin mononucleotide in riboflavin biosynthesis EC:2.7.1.26. Its structure resembles a RIFT barrel, structurally similar to but topologically distinct from bacterial and eukaryotic examples. The N-terminal is a winged helix-turn-helix DNA-binding domain, and the C-terminal half is most similar in sequence to a group of cradle-loop barrels. Swiss:O28174 has this domain attached to Pfam:PF00325.. 
+PF01983 DUF121;<br>Guanylyl transferase CofC like. Coenzyme F420 is a hydride carrier cofactor that functions during methanogenesis.  This family of proteins represents CofC, a nucleotidyl transferase that is involved in coenzyme F420 biosynthesis.  CofC has been shown to catalyse the formation of lactyl-2-diphospho-5'-guanosine from 2-phospho-L-lactate and GTP  .. 
+PF01986 Domain of unknown function DUF123<br>
+PF01987 DUF124;<br>Mitochondrial biogenesis AIM24. In eukaryotes, this domain is involved in mitochondrial biogenesis  . Its function in prokaryotes in unknown.. 
+PF01988 DUF125;<br>This family includes the vacuolar Fe2+/Mn2+ uptake transporter Swiss:P47818, Ccc1   and the vacuolar iron transporter VIT1 Swiss:Q9ZUA5.. 
+PF01989 Protein of unknown function DUF126<br>This archaebacterial protein family has no known function.. 
+PF01994 DUF127;<br>tRNA ribose 2'-O-methyltransferase, aTrm56. This family is an aTrm56 that catalyses the 2'-O-methylation of the cytidine residue in archaeal tRNA, using S-adenosyl-L-methionine. Biochemical assays showed that aTrm56 forms a dimer and prefers the L-shaped tRNA to the lambda form as its substrate    .  aTrm56 consists of the SPOUT domain, which contains the characteristic deep trefoil knot for AdoMet binding, and a unique C-terminal beta-hairpin  .. 
+PF01995 Domain of unknown function DUF128<br>This archaebacterial protein family has no known function. The domain is found duplicated in Swiss:O27611. Many of these are attached to an N-terminal winged helix domain suggesting these are transcriptional regulators and that this domain has a ligand binding function.. 
+PF01996 DUF129; <br>F420-0:Gamma-glutamyl ligase. F420-0:Gamma-glutamyl ligase (EC:6.3.2.-) is an enzyme involved in F420 biosynthesis pathway.  It catalyses the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0). This reaction produces polyglutamated F420 derivatives.  GTP + F420-0 + n L-glutamate -> GDP + phosphate + F420-n. 
+PF02343 DUF130; R03H10.4; <br>TRA-1 regulated protein R03H10.4. Pfam-B_814 (release 5.2). This family of proteins represents the protein product of the gene R03H10.4 which is located near a sequence that matches the TRA-1 binding consensus. TRA-1 is a transcription factor which controls sexual differentiation in C.elegans. R03H10.4 shows male-enriched reporter gene expression and acts as a direct target of TRA-1 regulation  .. 
+PF01998 Protein of unknown function DUF131<br>This archaebacterial protein family has no known function. The proteins are predicted to contain two transmembrane helices.. 
+PF02001 Protein of unknown function  DUF134<br>This family of archaeal proteins has no known function.. 
+PF02006 Protein of unknown function DUF137<br>This family of archaeal proteins has no known function.. 
+PF02363 DUF139; <br>Cysteine rich repeat. Pfam-B_602 (release 5.2). This Cysteine repeat C-X3-C-X3-C is repeated in sequences of  this family, 34 times in Swiss:O17970. The function of these repeats is unknown as is the function of the proteins in which they  occur.  Most of the sequences in this family are from C. elegans.. 
+PF02405 DUF140;<br>Pfam-B_1126 (release 5.2). This domain functions as a permease. In Swiss:Q7DD59 it is involved in L-glutamate import into the cell  . In Swiss:Q8L4R0 it is involved in lipid transfer within the cell  .. 
+PF02408 DUF141; <br>Pfam-B_1716 (release 5.4). This is a family of hypothetical C. elegans proteins.  The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.. 
+PF02410 DUF143;<br>Oligomerisation domain. Pfam-B_1798 (release 5.4). In yeasts, this domain is required for the oligomerisation of ATP synthase subunit 9 into a ring structure  .. 
+PF02413 DUF144; <br>Caudovirales tail fibre assembly protein. Pfam-B_1800 (release 5.4). This family contains bacterial and phage tail fibre assembly proteins  . E.coli contains several members of this family although the function of these proteins is uncertain.. 
+PF02415 DUF145; Chlamydia_PMP; <br>Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat. This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. Common for the Pmps are the tetrapeptide GGA(I/V/L) motif repeated several times in the N-terminal part. The C-terminal half is characterised by conserved tryptophans and a carboxy-terminal phenylalanine. A signal peptide leader sequence is predicted in 20 C. pneumoniae Pmps, which indicates an outer membrane localisation. Pmp10 and Pmp11 contain a signal peptidase II cleavage site suggesting lipid modification. The C. pneumoniae pmp genes represent 17.5% of the chlamydia-specific coding capacity and they are all transcribed during chlamydial growth but the function of Pmps remains unknown  . This family shows some similarity to Pfam:PF05594 and hence is likely to also form a beta-helical structure (personal obs:C Yeats).. 
+PF02457 DUF147; <br>DisA bacterial checkpoint controller nucleotide-binding. Pfam-B_1846 (release 5.4). The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. This domain is the first and is a globular, nucleotide-binding region; the next 146-289 residues constitute the DisA-linker family, Pfam:PF10635, that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), which thus forms a spine like-linker between domains 1 and 3. The C-terminal residues, of domain 3, are represented by family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis  .. 
+PF02520 Domain of unknown function DUF148<br>Pfam-B_1103 (release 5.4). This domain has no known function nor do any of the proteins that possess it.  In one member of this family Swiss:Q23614 the aligned region is repeated twice.. 
+PF02576 Uncharacterised BCR, YhbC family COG0779<br>
+PF02577 DUF151;<br>Bifunctional nuclease. This family is a bifunctional nuclease, with both DNase and RNase activity  . It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site  .. 
+PF02578 DUF152; Cu_oxidase_4; <br>Multi-copper polyphenol oxidoreductase laccase. Laccases are multi-copper oxidoreductases able to oxidise a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms  .. 
+PF02579 DUF153;<br>Dinitrogenase iron-molybdenum cofactor. This family contains several NIF (B, Y and X) proteins which are iron-molybdenum cofactors (FeMo-co) in the dinitrogenase enzyme which catalyses the reduction of dinitrogen to ammonium. Dinitrogenase is a hetero-tetrameric (alpha(2)beta(2)) enzyme which contains the iron-molybdenum cofactor (FeMo-co) at its active site  .. 
+PF02582 Uncharacterised ACR, YagE family COG1723<br>
+PF02585 DUF158; <br>GlcNAc-PI de-N-acetylase. Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyses the second step in GPI biosynthesis  .. 
+PF02586 Uncharacterised ACR, COG2135<br>
+PF01519 Protein of unknown function DUF16<br>Pfam-B_764 (release 4.0). The function of this protein is unknown.  It appears to only occur in Mycoplasma pneumoniae. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils  .. 
+PF02589 Uncharacterised ACR, YkgG family COG1556<br>
+PF02590 DUF163; <br>Predicted SPOUT methyltransferase. This family of proteins are predicted to be SPOUT methyltransferases  .. 
+PF02591 Putative zinc ribbon domain<br>Structural modelling suggests this domain may bind nucleic acids  .. 
+PF02592 Uncharacterized ACR, YhhQ family COG1738<br>
+PF02593 DUF166;<br>Thymidylate synthase. This family catalyses the synthesis of thymidine monophosphate (dTMP) from deoxyuridine monophosphate (dUMP). The physiological co-substrate has not yet been identified  .. 
+PF02594 Uncharacterised ACR, YggU family COG1872<br>
+PF02596 Uncharacterised ArCR, COG2043<br>
+PF02598 DUF171;<br>Putative RNA methyltransferase. This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA  , and may function as a methyltransferase [2,3].. 
+PF02604 DUF172; PhdYeFM;<br>Antitoxin Phd_YefM, type II toxin-antitoxin system. Members of this family act as antitoxins in type II toxin-antitoxin systems  .  When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin  .  This domain complexes with Txe toxins containing Pfam:PF06769, Fic/DOC toxins containing Pfam:PF02661 and YafO toxins containing Pfam:PF13957.. 
+PF02616 DUF173; <br>ScpA and ScpB participate in chromosomal partition during cell division. It may act via the formation of a condensin-like complex containing smc that pull DNA away from mid-cell into both cell halves. These proteins are part of the Kleisin superfamily.. 
+PF02617 DUF174; <br>ATP-dependent Clp protease adaptor protein ClpS. In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins  .. 
+PF02618 DUF175; ADC_lyase;<br>This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of Swiss:P28306 was solved by X-ray crystallography.. 
+PF02620 Uncharacterized ACR, COG1399<br>
+PF02621 DUF178;<br>Menaquinone biosynthesis. This family includes two enzymes which are involved in menaquinone biosynthesis. One which catalyses the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate, and one which may be involved in the conversion of chorismate to futalosine  . These enzymes comprise two domains with alpha/beta structures, a large domain and a small domain. A pocket between the two domains may form the active site, a conserved histidine located within this pocket could be the catalytic base  .. 
+PF02622 Uncharacterized ACR, COG1678<br>
+PF02623 DUF180; <br>The protein BSU35380 from Bacillus subtilis (renamed FliW) was characterised as being a flagellar assembly factor. Experimental characterisation was also carried out in Treponema pallidum (TP0658).  In Campylobacter jejuni, Cj1075 has been shown to be involved in motility and flagellin biosynthesis. The two paralogues in Helicobacter pylori (HP1154 and HP1377) were found to be able to bind to flagellin. FliW proteins are involved in flagellar assembly  . FliW is part of a three-part feedback loop: in Bacillus subtilis FliW inhibits CsrA (an RNA-binding protein) which inhibits FliC translation; hence FliW is required for FliC (flagellin) production  .. 
+PF02624 DUF181; <br>
+PF02636 DUF185;<br>Putative S-adenosyl-L-methionine-dependent methyltransferase. This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [1,2]. In eukaryotes it plays a role in mitochondrial complex I activity  .. 
+PF02638 Glycosyl hydrolase like GH101<br>
+PF01579 Domain of unknown function (DUF19)<br>Pfam-B_402 (release 4.1). This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins.  It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges.  The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.. 
+PF02643 Uncharacterized ACR, COG1430<br>Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologues are also present in several Plasmodium species).  TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homologue of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homologue in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).. 
+PF02645 DUF194; <br>Uncharacterised protein, DegV family COG1307. The structure of this protein revealed a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that this family has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism  .. 
+PF02646 DUF195; <br>This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures  . 
+PF02649 DUF198;<br>Type I GTP cyclohydrolase folE2. This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens . The invariate, highly conserved glutamate residue at position 216 in Swiss:Q5F9K6 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent  .. 
+PF02650 DUF199; <br>WhiA C-terminal HTH domain. This domain is found at the C-terminus of the sporulation regulator WhiA.  It is predicted to form a DNA-binding helix-turn-helix structure  .  The WhiA protein also contains two N-terminal domains that are distant homologues of LAGLIDADG homing endonucleases  .. 
+PF02655 DUF201; <br>
+PF02656 Domain of unknown function (DUF202)<br>This family consists of hypothetical proteins some of which are putative membrane proteins.  No functional information or experimental verification of function is known.  This domain is around 100 amino acids long.. 
+PF02659 Domain of unknown function DUF<br>This family consists of hypothetical transmembrane proteins non of which have any known function, the aligned region is 180 amino acids long.. 
+PF02660 DUF205;<br>Glycerol-3-phosphate acyltransferase. This family of enzymes catalyses the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid  ].. 
+PF02675 DUF206; AdoMetDC; <br>S-adenosylmethionine decarboxylase . This family contains several S-adenosylmethionine decarboxylase proteins from bacterial and archaebacterial species. S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesised as a proenzyme, which is cleaved post translationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity [1,2].. 
+PF02676 DUF207; <br>Methyltransferase TYW3. The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis  .  yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA.  TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner  .. 
+PF02677 Uncharacterized BCR, COG1636<br>
+PF02678 DUF209;<br>This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function of Pirin is unknown but the gene coding for this protein is known to be expressed in all tissues in the human body although it is expressed most strongly in the liver and heart. Pirin is known to be a nuclear protein, exclusively localised within the nucleoplasma and predominantly concentrated within dot-like subnuclear structures  . A tomato homologue of human Pirin has been found to be induced during programmed cell death  . Human Pirin interacts with Bcl-3 and NFI   and hence is probably involved in the regulation of DNA transcription and replication. It appears to be an Fe(II)-containing member of the Cupin superfamily.. 
+PF01595 Domain of unknown function DUF21<br>Pfam-B_618 (release 4.1). This transmembrane region has no known function.  Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Swiss:Q54318 that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains Pfam:PF00571.. 
+PF02679 DUF210;<br>(2R)-phospho-3-sulfolactate synthase (ComA). In methanobacteria (2R)-phospho-3-sulfolactate synthase (ComA) catalyses the first step of the biosynthesis of coenzyme M from phosphoenolpyruvate (P-enolpyruvate). This novel enzyme catalyses the stereospecific Michael addition of sulfite to P-enolpyruvate, forming L-2-phospho-3-sulfolactate (PSL). It is suggested that the ComA-catalysed reaction is analogous to those reactions catalysed by beta-elimination enzymes that proceed through an enolate intermediate  .. 
+PF02680 Uncharacterized ArCR, COG1888<br>
+PF02681 Divergent PAP2 family<br>This family is related to the Pfam:PF01569 family (personal obs: C Yeats).. 
+PF02697 Uncharacterized ACR, COG1753<br>Structural modelling suggests this domain may bind nucleic acids  .. 
+PF02698 DUF218 domain<br>
+PF01629 Domain of unknown function DUF22<br>Pfam-B_1137 (release 4.1). This domain is found in 1 to 3 copies in archaebacterial proteins.  The function of the domain is unknown. This family appears to be expanded in Archaeoglobus fulgidus.. 
+PF02713 Domain of unknown function DUF220<br>Pfam-B_1412 (release 5.5). This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned  region contains two cysteine residues.. 
+PF02714 Domain of unknown function DUF221<br>Pfam-B_1596 (release 5.5). This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.. 
+PF02720 Domain of unknown function (DUF222)<br>Pfam-B_1711 (release 5.5). This family is often found associated to the N-terminus of the HNH endonuclease domain Pfam:PF01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family  .. 
+PF02721 Domain of unknown function DUF223<br>Pfam-B_1714 (release 5.5). 
+PF02890 Borrelia family of unknown function DUF226<br>Pfam-B_1255 (release 6.0). This family of proteins are found in Borrelia.  The proteins are about 190 amino acids long and have no known function.. 
+PF02989 Lyme disease proteins of unknown function<br>Pfam-B_1298 (release 6.4). 
+PF03003 Poxvirus proteins of unknown function<br>Pfam-B_1300 (release 6.4). 
+PF03008 Archaea bacterial proteins of unknown function<br>Pfam-B_1430 (release 6.4). 
+PF03057 Protein of unknown function<br>Pfam-B_488 (release 6.4). This family represents the C-terminal region of a number of C. elegans proteins of unknown function.. 
+PF03072 MG032/MG096/MG288 family 1<br>Pfam-B_2298 (release 6.4). This family consists entirely of mycoplasmal proteins. Their function is unknown. Another related family, Pfam:PF03086, also consists entirely of mycoplasmal proteins of the MG032/MG096/MG288 family. Some proteins, such as Swiss:P75072, are included in both families, but of course differ in the aligned residues.. 
+PF01638 DUF24;<br>HxlR-like helix-turn-helix. Pfam-B_1509 (release 4.1). HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.. 
+PF03086 MG032/MG096/MG288 family 2<br>Pfam-B_2385 (release 6.4). This family consists entirely of mycoplasmal proteins. Their function is unknown. Another related family, Pfam:PF03072, also consists entirely of mycoplasmal proteins of the MG032/MG096/MG288 family. Some proteins, such as Swiss:P75072, are included in both families, but of course differ in the aligned residues.. 
+PF03112 Uncharacterized protein family (ORF7) DUF<br>Pfam-B_2667 (release 6.5). Several members of this family are Borrelia burgdorferi plasmid proteins of uncharacterized function.. 
+PF03136 DUF245; Proteosome_20S;<br>Pfam-B_3042 (release 6.5). Pupylation is a novel protein modification system found in some bacteria  . This family of proteins are the enzyme that can conjugate proteins of the Pup family to lysine residues in target proteins marking them for degradation. The archetypal protein in this family is PafA (proteasome accessory factor) from Mycobacterium tuberculosis  . It has been suggested that these proteins are related to gamma-glutamyl-cysteine synthetases  .. 
+PF03158 Multigene family 530 protein<br>Pfam-B_2304 (release 6.5). Members of this family are multigene family 530 proteins from African swine fever viruses. These proteins may be involved in promoting survival of infected macrophages  .. 
+PF03151 DUF250; <br>Triose-phosphate Transporter family. Pfam-B_3234 (release 6.5). This family includes transporters with a specificity for triose phosphate  .. 
+PF03159 DUF251; <br>XRN 5'-3' exonuclease N-terminus. Pfam-B_2349 (release 6.5). This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus  .. 
+PF03162 DUF252; <br>Tyrosine phosphatase family. Pfam-B_3756 (release 6.5). This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.. 
+PF03190 DUF255;<br>Protein of unknown function, DUF255. Pfam-B_2331 (release 6.5). 
+PF03192 Pyrococcus protein of unknown function, DUF257<br>Pfam-B_2788 (release 6.5). 
+PF03193 Protein of unknown function, DUF258<br>Pfam-B_2832 (release 6.5). 
+PF03196 Protein of unknown function, DUF261<br>Pfam-B_2687 (release 6.5). 
+PF03235 Protein of unknown function DUF262<br>Pfam-B_3462 (release 6.5). 
+PF03237 DUF264; <br>Terminase-like family. Pfam-B_3575 (release 6.5). This family represents a group of terminase proteins.. 
+PF03266 DUF265;<br>Pfam-B_4081 (release 6.5). This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase  . The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme  . The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue  .. 
+PF03270 Protein of unknown function, DUF269<br>Pfam-B_4172 (release 6.5). Members of this family may be involved in nitrogen fixation, since they are found within nitrogen fixation operons.. 
+PF03189 DUF270; <br>Pfam-B_2323 (release 6.5). 
+PF03407 DUF271; <br>Nucleotide-diphospho-sugar transferase. Pfam-B_4460 (release 6.6). Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.. 
+PF03314 Protein of unknown function, DUF273<br>Pfam-B_3636 (release 6.5). 
+PF03434 DUF276 <br>Pfam-B_4450 (release 6.6). This family is specific to Borrelia burgdorferi.  The protein is encoded on extra-chromosomal DNA.\.     This domain has no known function.. 
+PF03353 DUF278; Lin-8_Ec; Lin-8_Ce; <br>Ras-mediated vulval-induction antagonist. Pfam-B_3924 (release 6.5). LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb.Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling  . The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity  .. 
+PF01709 DUF28;<br>Transcriptional regulator. Pfam-B_1741 (release 4.1). This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1  . In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region  .. 
+PF03436 Domain of unknown function (DUF281) <br>Pfam-B_4313 (release 6.6). This family of worm domain has no known function. The boundaries of the presumed domain are rather uncertain.. 
+PF03383 DUF286; <br>Caenorhabditis serpentine receptor-like protein, class xa. Pfam-B_2888 (release 6.6). This family contains various Caenorhabditis proteins, some of which are annotated as being serpentine receptors, mainly of the xa class.. 
+PF03384 Drosophila protein of unknown function, DUF287<br>Pfam-B_2926 (release 6.6). 
+PF03385 Protein of unknown function, DUF288<br>Pfam-B_3134 (release 6.6). 
+PF01062 Worm_family_8;DUF289; <br>Bestrophin, RFP-TM, chloride channel. Bestrophin is a 68-kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a depressed light peak in the electrooculogram  .  VMD2 encodes a 585-amino acid protein with an approximate mass of 68 kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif.  Bestrophin is a plasma membrane protein, localised to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of chloride channels, indicating a direct role for bestrophin in generating the light peak  . The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal RFP-TM domain implying important functional properties  . The bestrophins are four-pass transmembrane chloride-channel proteins  , and the RFP-TM or bestrophin domain extends from the N-terminus through approximately 350 amino acids and contains all of the TM domains as well as nearly all reported disease causing mutations  . Interestingly, the RFP motif is not conserved evolutionarily back beyond Metazoa, neither is it in plant members.. 
+PF01724 Domain of unknown function DUF29<br>Pfam-B_2003 (release 4.1). This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Swiss:Q2RPE2, PDB:3fcn, is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerisation module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.. 
+PF03442 DUF291;<br>Carbohydrate binding domain X2. This domain binds to cellulose and to bacterial cell walls. It is found in glycosyl hydrolases and in scaffolding proteins of cellulosomes (multiprotein glycosyl hydrolase complexes). In the cellulosome it may aid cellulose degradation by anchoring the cellulosome to the bacterial cell wall and by binding it to its substrate  . This domain has an Ig-like fold  .. 
+PF03398 DUF292; <br>Regulator of Vps4 activity in the MVB pathway. Pfam-B_3833 (release 6.6). ESCRT-I, -II, and -III are endosomal sorting complexes required for transporting proteins and carry out cargo sorting and vesicle formation in the multivesicular bodies, MVBs, pathway. These complexes are transiently recruited from the cytoplasm to the endosomal membrane where they bind transmembrane proteins previously marked for degradation by mono-ubiquitination. Assembly of ESCRT-III, a complex composed of at least four subunits (Vps2, Vps24, Vps20, Snf7), is intimately linked with MVB vesicle formation, its disassembly being an essential step in the MVB vesicle formation, a reaction that is carried out by Vps4, an AAA-type ATPase. The family Ist1 is a regulator of Vps4 activity; by interacting with Did2 and Vps4, Ist1 appears to regulate the recruitment and oligomerisation of Vps4. Together Ist1, Did2, and Vta1 form a network of interconnected regulatory proteins that modulate Vps4 activity, thereby regulating the flow of cargo through the MVB pathway  .. 
+PF03444 DUF293;<br>Winged helix-turn-helix transcription repressor, HrcA DNA-binding. This domain is always found with a pair of CBS domains Pfam:PF00571.. 
+PF03445 Putative nucleotidyltransferase DUF294<br>This domain is found associated with Pfam:PF00571.  This region is uncharacterised, however it seems to be similar to Pfam:PF01909, conserving the DXD motif.\. 
+PF03479 Domain of unknown function (DUF296)<br>Pfam-B_796 (release 7.0) & Dlakic M. This putative domain is found in proteins that contain AT-hook motifs Pfam:PF02178, which strongly suggests a DNA-binding function for the proteins as a whole. There are three highly conserved histidine residues, eg at 117, 119 and 133 in Swiss:Q46QL5, which should be a structurally conserved metal-binding unit, based on structural comparison with known metal-binding structures. The proteins should work as trimers.. 
+PF03537 DUF297; Glyco_hydro_114; GHL7;<br>Glycoside-hydrolase family GH114. This family is recognised as a glycosyl-hydrolase family, number 114.  It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases  .. 
+PF03618 DUF299;<br>Kinase/pyrophosphorylase. Pfam-B_3403 (release 7.0). This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity [1-3].. 
+PF03625 Domain of unknown function DUF302 <br>Domain is found in an undescribed set of proteins. Normally occurs uniquely within a sequence, but is found as a tandem repeat (Swiss:Q9X8B8). Shows interesting phylogenetic distribution with majority of examples in bacteria and archaea, but also in in D.melanogaster (e.g. Swiss:Q9VA18).. 
+PF03629 Domain of unknown function (DUF303) <br>Pfam-B_3622 (release 7.0). Distribution of this domain seems limited to prokaryotes and viruses. . 
+PF03733 Domain of unknown function (DUF307)<br>Domain occurs as one or more copies in a small family of putative membrane proteins.. 
+PF03729 RUF1; <br>Short repeat of unknown function (DUF308). Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X  (#=hydrophobic).. 
+PF03745 Domain of unknown function (DUF309)<br>This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.. 
+PF01732 Putative peptidase (DUF31)<br>Pfam-B_2152 (release 4.1). This domain has no known function. It is found in various hypothetical proteins and putative lipoproteins from mycoplasmas. It appears to be related to the superfamily of trypsin peptidases and so may have a peptidase function.. 
+PF03750 Protein of unknown function (DUF310)<br>This family contains a number of archaeal proteins that are completely uncharacterised. The proteins are between 130 and 160 amino acids long. Their C-terminus contains several conserved residues.. 
+PF03759 DUF315; <br>PRONE (Plant-specific Rop nucleotide exchanger). Pfam-B_3610 (release 7.0). This is a functional guanine exchange factor (GEF) of plant Rho GTPase  .. 
+PF03773 Predicted permease<br>This family of integral membrane proteins are predicted to be permeases of unknown specificity.. 
+PF03778 Protein of unknown function (DUF321) <br>Pfam-B_876 (release 7.0). This family may be related to the FARP (FMRFamide) family, Pfam:PF01581.  Currently this repeat was only detectable in Arabidopsis thaliana. . 
+PF03780 DUF322;<br>The alkaline shock protein Asp23 was identified as an alkaline shock protein   that was expressed in a sigmaB-dependent manner in Staphylococcus aureus.. 
+PF03781 DUF323; <br>Sulfatase-modifying factor enzyme 1. This domain is found in eukaryotic proteins   required for post-translational sulfatase modification (SUMF1).  These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD)  . The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase.  Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases  . FGE is localised to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesised sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilised by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidised cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases  . In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase [5,6].. 
+PF03787 DUF324; <br>COG1332, COG1567, COG1367. The molecular function of these proteins is not yet known.  However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.. 
+PF03804 Viral domain of unknown function<br>
+PF03885 Protein of unknown function (DUF327)<br>The proteins in this family are around 140-170 residues in length. The proteins contain many conserved residues. with the most conserved motifs found in the central and C-terminal region. The function of these proteins is unknown.. 
+PF03883 Protein of unknown function (DUF328)<br>Members of this family are functionally uncharacterised. They are about 250 amino acids in length.. 
+PF03884 Domain of unknown function (DUF329)<br>The function of this short domain is unknown it contains four conserved cysteines and may therefore be involved in zinc binding.. 
+PF03886 Protein of unknown function (DUF330)<br>The proteins in this family are uncharacterised. The proteins are 170-190 amino residues in length.. 
+PF03889 Domain of unknown function<br>Members of this family are uncharacterised proteins from a number of bacterial species.  The proteins range in size from 50-70 residues.. 
+PF03891 Domain of unknown function (DUF333)<br>This small domain of about 70 residues is found in a number of bacterial proteins.  It is found at the N-terminus the of Swiss:O28332 protein. The proteins containing this domain are uncharacterised.. 
+PF03904 Domain of unknown function (DUF334)<br>Staphylococcus aureus plasmid proteins with no characterised function.. 
+PF03928 Domain of unknown function (DUF336)<br>This family contains uncharacterised sequences, including several GlcG proteins. The alignment contains many conserved motifs that are suggestive of cofactor binding and  enzymatic activity.. 
+PF03929 DUF337;<br>PepSY-associated TM helix. 
+PF03937 DUF339; TPR_div1;<br>Flavinator of succinate dehydrogenase. This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle.\. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans  . Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria  .  This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true.. 
+PF01784 DUF34;<br>NIF3 (NGG1p interacting factor 3). Pfam-B_1006 (release 4.2). This family contains several NIF3 (NGG1p interacting factor 3) protein homologues. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown [1,2].. 
+PF03956 Membrane protein of unknown function (DUF340)<br>Members of this family contain a conserved core of four predicted transmembrane segments.  Some members have an additional pair of N-terminal transmembrane helices. The functions of the proteins in this family are unknown.. 
+PF03959 DUF341; <br>Serine hydrolase (FSH1). This is a family of serine hydrolases  .. 
+PF03961 Protein of unknown function (DUF342)<br>This family of bacterial proteins has no known function. The proteins are in the region of 500-600 amino acid residues in length.. 
+PF03966 DUF343; <br>Trm112p-like protein. The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length.  The C terminus contains the strongest conservation.  Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W  . The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast  . The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices  .. 
+PF03976 DUF344; <br>Polyphosphate kinase 2 (PPK2). Inorganic polyphosphate (polyP) plays a role in metabolism and regulation and has been proposed to serve as a energy source in a pre-ATP world.  In prokaryotes, the synthesis and utilisation of polyP are catalysed by PPK1, PPK2 and polyphosphatases.  Proteins with a single PPK2 domain catalyse polyP-dependent phosphorylation of ADP to ATP, whereas proteins containing 2 fused PPK2 domains phosphorylate AMP to ADP.\.       The structure of PPK2 from Pseudomonas aeruginosa has revealed a a 3-layer alpha/beta/alpha sandwich fold with an alpha-helical lid similar to the structures of microbial thymidylate kinases  .. 
+PF03978 DUF345; <br>Borrelia burgdorferi REV protein. Pfam-B_26177 (release 7.2). This family consists of several REV proteins from Borrelia burgdorferi (Lyme disease spirochete). The function of REV is unknown although it known that gene is induced during the ingesting of host blood suggesting a role in the metabolic activation of borreliae to adapt to physiological stimuli  .. 
+PF03984 Repeat of unknown function (DUF346)  <br>This repeat was found as seven tandem copies in one protein. It is predicted to be composed of beta-strands. Thus it is likely that it forms a beta-propeller structure. It is found in association with BNR repeats, which also form a  beta-propeller.. 
+PF03988 Repeat of Unknown Function (DUF347) <br>This repeat is found as four tandem repeats in a family of bacterial membrane proteins. Each repeat contains two transmembrane regions and a conserved tryptophan.. 
+PF01796 DUF35 OB-fold domain<br>Pfam-B_1390 (release 4.2). This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins. The domain is approximately 70 amino acids long. The domain is duplicated in Swiss:O53566.  The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain and a C-terminal OB fold domain represented in this entry.  OB-folds are frequently found to bind nucleic acids suggesting this domain might bind to DNA or RNA.. 
+PF03994 Domain of Unknown Function (DUF350) <br>This domain occurs in a small set of of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues.. 
+PF03995 DUF351;<br>Peptidase inhibitor family I36. This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C (Swiss:Q9ADK5) and SCO3675 (Swiss:Q9X8V7) also have probable beta-propellers at their C-termini. This family includes Swiss:P01077 a known peptidase inhibitor of known structure. This protein has a crystallin like fold Pfam:PF00030 and is distantly related by sequence.  It is not known whether other members of this family are peptidase inhibitors.. 
+PF04001 DUF352; <br>Transcription factor Vhr1. Vhr1 is a transcription factor which regulates the biotin-dependent expression of transporters VHT1 and BIO5  .. 
+PF04007 Protein of unknown function (DUF354)<br>Members of this family are around 350 amino acids in length. They are found in archaebacteria and have no known function.. 
+PF04009 Protein of unknown function (DUF356)<br>Members of this family are around 120 amino acids in length and are found in some archaebacteria.  The function of this family is unknown.  However it contains a conserved motif IHPPAH that may be involved in its function.. 
+PF04010 Protein of unknown function (DUF357)<br>Members of this family are short (less than 100 amino acid) proteins found in archaebacteria.  The function of these proteins is unknown.. 
+PF04019 Protein of unknown function (DUF359)<br>This family of archaebacterial proteins are about 170 amino acids in length.  They have no known function. The most conserved portion of the protein contains the sequence GEEDL that may be important for its function.. 
+PF04021 DUF361; Type_III_signal; <br>Class III signal peptide. This family of archaeal proteins contains.  an amino terminal motif QXSXEXXXL that has been suggested to be part of a class III signal sequence. With the Q being the +1 residue of the signal peptidase cleavage site  . Two members of this family are cleaved by a type IV pilin-like signal peptidase.. 
+PF04015 Domain of unknown function (DUF362) <br>Domain that is sometimes present in iron-sulphur proteins.. 
+PF04016 Domain of unknown function (DUF364)<br>This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, Pfam:PF13938.. 
+PF04033 Domain of unknown function (DUF365)<br>Archaeal domain of unknown function.. 
+PF04017 Domain of unknown function (DUF366)<br>Archaeal domain of unknown function.. 
+PF04034 Domain of unknown function (DUF367)<br>
+PF04018 Domain of unknown function (DUF368)<br>Predicted transmembrane domain of unknown function.  Family members have between 6 and 9 predicted transmembrane segments.. 
+PF04126 DUF369;<br>This domain has a cyclophilin-like fold, consisting of an eight-stranded beta-barrel with an alpha helix located between the beta-2 and beta-3 strands and a 310 helix located between the beta-7 and beta-8 strands. The catalytic site found in human cyclophilin is not conserved in this domain, suggesting a different function for this domain [1,2].. 
+PF01809 DUF37;<br>Pfam-B_1485 (release 4.2). This domain has haemolytic activity  . It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.. 
+PF04025 Domain of unknown function (DUF370)<br>Bacterial domain of unknown function.. 
+PF04027 Domain of unknown function (DUF371)<br>Archaeal domain of unknown function.. 
+PF04036 Domain of unknown function (DUF372)<br>Domain of unknown function.. 
+PF04123 Domain of unknown function (DUF373)<br>Archaeal domain of unknown function.  Predicted to be an integral membrane protein with six transmembrane regions.. 
+PF04028 Domain of unknown function (DUF374)<br>Bacterial domain of unknown function.. 
+PF04041 Domain of unknown function (DUF377)<br>This family contains many hypothetical proteins, some of which are predicted to be glycosyl hydrolases. This family was noted to belong to the Beta fructosidase superfamily in  .. 
+PF04070 Domain of unknown function (DUF378)<br>Predicted transmembrane domain of unknown function.  The majority of the family have two predicted transmembrane regions.. 
+PF04038 Domain of unknown function (DUF381)<br>Archaeal domain of unknown function.  Strongly conserved YPLM motif.. 
+PF04063 Domain of unknown function (DUF383)<br>
+PF04064 Domain of unknown function (DUF384)<br>
+PF04074 Domain of unknown function (DUF386)<br>TIGRFAMs (release 2.0);. This family consists of conserved hypothetical proteins,  typically about 150 amino acids in length, with no known  function.. 
+PF04079 Putative transcriptional regulators (Ypuh-like)<br>TIGRFAMs (release 2.0);. This family of conserved bacterial proteins are thought to possibly be helix-turn-helix type transcriptional regulators.. 
+PF04076 DUF388; <br>Bacterial OB fold (BOF) protein. TIGRFAMs (release 2.0);. Proteins in this family form an OB-fold.  Analysis of the predicted binding site of BOF family proteins implies that they lack nucleic acid-binding properties  .  They contain an predicted N-terminal signal peptide which indicates that they localise in the periplasm where they may function to bind proteins, small molecules, or other typical OB-fold ligands  . As hypothesised for the distantly related OB-fold containing bacterial enterotoxins, the loss of nucleotide-binding function and the rapid evolution of the BOF ligand-binding site may be associated with the presence of BOF proteins in mobile genetic elements and their potential role in bacterial pathogenicity  .. 
+PF01837 Domain of unknown function DUF39<br>Pfam-B_7373 (release 4.0). This presumed domain is about is about 360 residues long. The function of this domain is unknown. It is found in some proteins that have two C-terminal CBS Pfam:PF00571 domains. There are also proteins that contain two inserted Fe4S domains near the C-terminal end of the domain.  The protein Swiss:O26943 has been misannotated as an inosine monophosphate dehydrogenase based on the similarity to the CBS domains.. 
+PF04094 Protein of unknown function (DUF390)<br>Pfam-B_1698 (release 7.3). This is a family of long proteins currently only found in the rice genome. They have no known function. However they may be some kind of transposable element.. 
+PF04134 Protein of unknown function, DUF393<br>Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.. 
+PF04143 DUF395;<br>Pfam-B_2577 (release 7.3). This is an integral membrane protein. It is predicted to have a function in the transport of sulphur-containing molecules  .  It contains several conserved glycines and an invariant cysteine that is probably an important functional residue.. 
+PF04148 DUF396; <br>Transmembrane adaptor Erv26. Pfam-B_22900 (release 7.3);. Erv26 is an integral membrane protein that is packed into COPII vesicles and cycles between the ER and Golgi compartments.  It directs pro-alkaline phosphatase into endoplasmic reticulum-derived COPII transport vesicles  .. 
+PF04149 Domain of unknown function (DUF397)<br>Pfam-B_3066 (release 7.3). The function of this family is unknown. It has been suggested that some members of this family are regulators of transcription. In  particular, it is thought that this may regulator of antibiotic production in Streptomyces coelicolor  .  . 
+PF04187 Protein of unknown function, DUF399<br>No function is known for any member of this family.. 
+PF04165 Protein of unknown function (DUF401) <br>TIGRFAMs (release 2.0);. Members if this family are predicted to have 10 transmembrane  regions.. 
+PF04167 Protein of unknown function (DUF402)<br>Family member FomD is a predicted protein from a fosfomycin biosynthesis gene cluster in Streptomyces wedmorensis  .  Its function is unknown.. 
+PF04168 DUF403;<br>A predicted alpha-helical domain with a conserved ER motif.. An uncharacterized alpha helical domain containing a highly  conserved ER motif and typically found as a tandem duplication.  Contextual analysis suggests that it functions in a distinct peptide  synthesis/modification system comprising of a transglutaminase,  a peptidase of the NTN-hydrolase superfamily, an active and inactive  circularly permuted ATP-grasp domains and a transglutaminase fused  N-terminal to a circularly permuted COOH-NH2 ligase domain  .. 
+PF04175 Protein of unknown function (DUF406) <br>TIGRFAMs (release 2.0);. Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterised enzyme specific for gamma proteobacteria.. 
+PF04174 DUF407;<br>A circularly permuted ATPgrasp . An ATP-grasp family that is present both as catalytically active  and inactive versions. Contextual analysis suggests that  it functions in a distinct peptide synthesis/modification system  that additionally contains a transglutaminase, an NTN-hydrolase,  the Alpha-E domain, and a transglutaminase fused N-terminal to a  circularly permuted COOH-NH2 ligase. The inactive forms are often  fused N-terminal to the Alpha-E domain  .. 
+PF04181 DUF408; <br>Pfam-B_22202 (release 7.3);. This family includes the human RPAP2 (RNAP II associated polypeptide) protein and the yeast Rtr1 protein  . It has been suggested that this family of proteins are regulators of core RNA polymerase II function  .. 
+PF04188 DUF409; <br>Mannosyltransferase (PIG-V)). Pfam-B_9248 (release 7.3);. This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface.  Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI    .. 
+PF04190 Protein of unknown function (DUF410) <br>Pfam-B_12495 (release 7.3);. This family of proteins is from Caenorhabditis elegans and has no known function. The protein has some GO references indicating that the protein has a positive regulation of growth rate and is involved in nematode larval development.. 
+PF04214 Protein of unknown function, DUF<br>The function of the members of this bacterial protein family is unknown. Some members may be involved in conferring cation resistance.. 
+PF04217 Protein of unknown function, DUF412<br>This family consists of bacterial uncharacterised proteins.. 
+PF04219 Protein of unknown function, DUF<br>
+PF04220 DUF414;<br>Der GTPase activator (YihI). YihI activates the GTPase activity of Der, a 50S ribosomal subunit stability factor  .  The stimulation is specific to Der as YihI does not stimulate the GTPase activity of Era or ObgE. The interaction of YihI with Der requires only the C-terminal 78 amino acids of YihI  . A yihI deletion mutant is viable and shows a shorter lag period, but the same post-lag growth rate as a wild-type strain. yihI is expressed during the lag period. Overexpression of yihI inhibits cell growth and biogenesis of the 50S ribosomal subunit  . YihI is an unusual, highly hydrophilic protein with an uneven distribution of charged residues, resulting in an N-terminal region with high pI and a C-terminal region with low pI  .. 
+PF04222 Protein of unknown function (DUF416)<br>This is a bacterial protein family of unknown function.  Proteins in this family adopt an alpha helical structure.  Genome context analysis has suggested a high probability of a functional association with histidine kinases, which implicates proteins in this family to play a role in signalling (information from TOPSAN 2Q9R).. 
+PF04224 Protein of unknown function, DUF417<br>This family of uncharacterised proteins appears to be restricted to proteobacteria.. 
+PF04235 Protein of unknown function (DUF418)<br>Probable integral membrane protein.. 
+PF04237 DUF419;<br>YjbR has a CyaY-like fold  . 
+PF04238 Protein of unknown function (DUF420)<br>Predicted membrane protein with four transmembrane helices.. 
+PF04239 Protein of unknown function (DUF421)<br>
+PF04240 Protein of unknown function (DUF422)<br>Predicted to be an integral membrane protein.. 
+PF04242 Protein of unknown function (DUF424)<br>This is a family of uncharacterised proteins.. 
+PF04248 Domain of unknown function (DUF427)<br>
+PF04250 Protein of unknown function (DUF429)<br>
+PF01861 Protein of unknown function DUF43<br>This family includes archaebacterial proteins of unknown function.  All the members are 350-400 amino acids long.. 
+PF04254 Protein of unknown function (DUF432)<br>Archaeal protein of unknown function.. 
+PF04256 Protein of unknown function (DUF434)<br>
+PF04258 DUF435; <br>Signal peptide peptidase. The members of this family are membrane proteins. In some proteins this region is found associated with Pfam:PF02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with Pfam:PF01080.. 
+PF04260 Protein of unknown function (DUF436) <br>TIGRFAMs (release 2.0);. Family of bacterial proteins with undetermined function. . 
+PF04266 DUF437; <br>The ASCH domain adopts a beta-barrel fold similar to the Pfam:PF01472 domain  .  It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation  .. 
+PF04282 Family of unknown function (DUF438)<br>
+PF04283 DUF439;<br>Chemotaxis signal transduction system protein F from archaea. This is a family of proteins that are archaea-specific components of the bacterial-like chemotaxis signal transduction system of archaea. In H. salinarum, the CheF proteins interact with the chemotaxis proteins CheY, CheD and CheC2 as well as the flagella-accessory proteins FlaCE and FlaD, and are essential for any tactic response. CheF probably functions at the interface between the bacterial-like chemotaxis signal transduction system and the archaeal flagellar apparatus.. 
+PF04269 Protein of unknown function, DUF440<br>This family consists of uncharacterised bacterial proteins.. 
+PF04284 Protein of unknown function (DUF441)<br>Predicted to be an integral membrane protein.. 
+PF04273 Putative phosphatase (DUF442)<br>TIGRFAMs (release 2.0);. Although this domain is uncharacterised it seems likely that it performs a phosphatase function.. 
+PF04276 Protein of unknown function (DUF443) <br>TIGRFAMs (release 2.0);. Family of uncharacterised proteins.. 
+PF04285 Protein of unknown function (DUF444)<br>Bacterial protein of unknown function.  One family member (Swiss:Q97LI1) is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA).. 
+PF04286 Protein of unknown function (DUF445)<br>Predicted to be a membrane protein.. 
+PF04287 tRNA pseudouridine synthase C<br>This family is suggested to be the catalytic domain of tRNA pseudouridine synthase C by association. The structure has been solved for one member, as PDB:2HGK, which by inference is designated in this way.. 
+PF04289 Protein of unknown function (DUF447)<br>Archaeal protein of unknown function.. 
+PF04296 Protein of unknown function (DUF448)<br>
+PF01863 Protein of unknown function DUF45<br>This protein has no known function.  Members are found in some archaebacteria, as well as Helicobacter pylori.  The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved histidines.  This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.. 
+PF04313 DUF450; <br>Type I restriction enzyme R protein N terminus (HSDR_N). This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA  . Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA  .. 
+PF04301 Protein of unknown function (DUF452)<br>
+PF04303 DUF453;<br>PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerise trans-aconitate to cis-aconitate  .. 
+PF04304 Protein of unknown function (DUF454)<br>Predicted membrane protein.. 
+PF04305 Protein of unknown function (DUF455)<br>
+PF04306 Protein of unknown function (DUF456)<br>This family is a putative membrane protein that contains glycine zipper motifs  .. 
+PF04307 Predicted membrane-bound metal-dependent hydrolase (DUF457)<br>Family of predicted membrane-bound metal-dependent hydrolases, based on Swiss:Q97LP7. May act as phospholipases.. 
+PF04308 Protein of unknown function (DUF458) <br>Family of uncharacterised eubacterial proteins.. 
+PF04311 Protein of unknown function (DUF459)<br>Putative periplasmic protein.. 
+PF01864 Putative integral membrane protein DUF46<br>This archaebacterial protein has no known function. It contains several predicted transmembrane regions, suggesting it is an integral membrane protein.. 
+PF04312 Protein of unknown function (DUF460)<br>Archaeal protein of unknown function.. 
+PF04314 Protein of unknown function (DUF461)<br>Putative membrane or periplasmic protein.. 
+PF04315 Protein of unknown function, DUF462<br>This family consists of bacterial proteins of uncharacterised function.. 
+PF04317 YcjX-like family, DUF463<br>These proteins possess a P-loop motif.. 
+PF04327 Protein of unknown function (DUF464)<br>
+PF04325 Protein of unknown function (DUF465)<br>Family members are found in small bacterial proteins, and also in the heavy chains of eukaryotic myosin and kinesin, C terminal of the motor domain (Myosin Pfam:PF00063, Kinesin Pfam:PF00225). Members of this family may form coiled coil structures.. 
+PF04328 Protein of unknown function (DUF466)<br>Small bacterial protein of unknown function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF04326 DUF467; AAA_div; <br>Divergent AAA domain. This family is related to the Pfam:PF00004 family, and presumably has the same function (ATP-binding).. 
+PF04318 Protein of unknown function (DUF468) <br>These conserved ORFs probably are probably not translated into protein [Personal communication, Val Wood].. 
+PF04320 Protein with unknown function (DUF469)<br>Family of bacteria protein with no known function.. 
+PF01865 DUF47; <br>Protein of unknown function DUF47. This family includes prokaryotic proteins of unknown function, as well as a protein annotated as the pit accessory protein from Sinorhizobium meliloti Swiss:O30498. However, the function of this protein is also unknown (Pit stands for Phosphate transport). It is probably distantly related to Pfam:PF01895 (personal obs:Yeats C).. 
+PF04322 Protein of unknown function (DUF473)<br>Family of uncharacterised Archaeal proteins.. 
+PF04536 DUF477; Repair_PSII; Phosphatase;<br>TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase. COG1512 & Pfam-B_18715 (release 10.0). This family has a Rossmann-like fold. It has phosphatase activity  .. 
+PF04334 Protein of unknown function (DUF478)<br>This family contains uncharacterised protein encoded on Trypanosoma kinetoplast minicircles.. 
+PF04336 Protein of unknown function, DUF479<br>This family includes several bacterial proteins of uncharacterised function.. 
+PF01867 DUF48;<br>CRISPR associated protein Cas1. Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein.  Cas1 may be involved in linking DNA segments to CRISPR  .. 
+PF04337 Protein of unknown function, DUF480<br>This family consists of several proteins of uncharacterised function.. 
+PF04338 Protein of unknown function, DUF481<br>This family includes several proteins of uncharacterised function.. 
+PF04339 Protein of unknown function, DUF482<br>This family contains several proteins of uncharacterised function.. 
+PF04467 Protein of unknown function (DUF483)<br>Family of uncharacterised prokaryotic proteins.. 
+PF04340 Protein of unknown function, DUF484<br>This family consists of several proteins of uncharacterised function.. 
+PF04341 Protein of unknown function, DUF485<br>This family includes several putative integral membrane proteins.. 
+PF04342 Protein of unknown function, DUF486<br>This family contains several proteins of uncharacterised function.. 
+PF04343 Protein of unknown function, DUF488<br>This family includes several proteins of uncharacterised function.. 
+PF04356 Protein of unknown function (DUF489)<br>Protein of unknown function, cotranscribed with purB in Escherichia coli, but with function unrelated to purine biosynthesis  .. 
+PF04357 Family of unknown function (DUF490)<br>
+PF04361 Protein of unknown function (DUF494)<br>Members of this family of uncharacterised proteins are often named Smg.. 
+PF04362 DUF495; <br>Bacterial Fe(2+) trafficking. This is a family of bacterial Fe(2+) trafficking proteins.. 
+PF04363 Protein of unknown function (DUF496)<br>
+PF04365 Protein of unknown function (DUF497)<br>
+PF04430 Protein of unknown function (DUF498/DUF598)<br>This is a large family of uncharacterised proteins found in all domains of life.  The structure shows a novel fold with three beta sheets.  A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid  .. 
+PF00674 DUP family<br>Pfam-B_99 (release 2.1). This family consists of several yeast proteins of unknown functions.  Swiss-prot annotates these as belonging to the DUP family. Several members of this family contain an internal duplication of this region.. 
+PF04465 Protein of unknown function (DUF499)<br>Family of uncharacterised hypothetical prokaryotic proteins.. 
+PF04366 Family of unknown function (DUF500)<br>Proteins in this family often also contain an SH3 domain (Pfam:PF00018), or a FYVE zinc finger (Pfam:PF01363).. 
+PF04417 Protein of unknown function (DUF501)<br>Family of uncharacterised bacterial proteins.. 
+PF04367 Protein of unknown function (DUF502)<br>Predicted to be an integral membrane protein.. 
+PF04456 Protein of unknown function (DUF503)<br>Family of hypothetical bacterial proteins.. 
+PF04457 Protein of unknown function (DUF504)<br>Family of uncharacterised proteins.. 
+PF04458 Protein of unknown function (DUF505)<br>Family of uncharacterised prokaryotic proteins.. 
+PF04368 Protein of unknown function (DUF507)<br>Bacterial protein of unknown function.. 
+PF04370 Domain of unknown function (DUF508) <br>This is a family of uncharacterised proteins from C. elegans.. 
+PF01871 DUF51; <br>This family consists of several AMMECR1 as well as several uncharacterised proteins. The contiguous gene deletion syndrome AMME is characterised by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1  . This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery  .. 
+PF04459 Protein of unknown function (DUF512)<br>Family of uncharacterised prokaryotic proteins.. 
+PF04375 DUF513; <br>This family consists of several bacterial HemX proteins. The hemX gene is not essential for haem synthesis in B. subtilis. HemX is a polytopic membrane protein which by an unknown mechanism down-regulates the level of HemA  .. 
+PF04415 Protein of unknown function (DUF515)    <br>Family of hypothetical Archaeal proteins.. 
+PF04414 DUF516; <br>D-aminoacyl-tRNA deacylase. Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tRNA. D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules.. 
+PF04378 DUF519;<br>Ribosomal RNA small subunit methyltransferase D, RsmJ. RsmJ is the tenth to be found of the ten methyltransferases required for full methylation of 16S ribosomal RNA (rRNA). It specifically methylates m(2)G1516. A strain of E.coli lacking RsmJ due to deletion of the rsmJ(yhiQ) gene is missing the methyl group at G1516 and exhibits a cold-sensitive phenotype.. 
+PF04461 Protein of unknown function (DUF520)<br>Family of uncharacterised proteins.. 
+PF04412 Protein of unknown function (DUF521)<br>Family of hypothetical proteins.. 
+PF04463 Protein of unknown function (DUF523)<br>Family of uncharacterised bacterial proteins.. 
+PF04411 Protein of unknown function (DUF524)<br>This domain has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches  .  The domain has two additional beta-strands inserted to the core fold after the first core alpha-helix.\.       It has been speculated that it could function as s methylation-dependent restriction  .. 
+PF04379 Protein of unknown function (DUF525)<br>Members of this family include the bacterial protein ApaG and the C termini of some F-box proteins (Pfam:PF00646).  F-box proteins contain a carboxyl-terminal domain that interacts with protein substrates  , so this family may be involved in protein-protein interaction.  The function of ApaG proteins is unknown, but mutations in the Salmonella typhimurium ApaG homologue corD gives a phenotype of low-level cobalt resistance and decreased magnesium efflux by effects on the CorA magnesium transport system  .. 
+PF04380 DUF526;<br>Membrane fusogenic activity. BMFP consists of two structural domains, a coiled-coil C-terminal domain via which the protein self-associates as a trimer, and an N-terminal domain disordered at neutral pH but adopting an amphipathic alpha-helical structure in the presence of phospholipid vesicles, high ionic strength, acidic pH or SDS. BMFP interacts with phospholipid vesicles though the predicted amphipathic alpha-helix induced in the N-terminal half of the protein and promotes aggregation and fusion of vesicles in vitro.. 
+PF04384 DUF528;<br>Iron-sulphur cluster assembly. This family of proteins is likely to be involved in the assembly of iron-sulphur clusters. It may function as an adaptor protein. In Escherichia coli Swiss:P0C0L9 forms part of the isc operon, which encodes genes involved in iron-sulphur cluster assembly. Its structure is entirely alpha helical, and it contains a modified wing-helix structure, usually found in DNA-binding proteins. It binds to Fe2+ and Fe3+ ions and to the cysteine desulfurase IscS, the same surface of the protein is involved in both binding to iron and to IscS [1,2].. 
+PF04385 DUF529; <br>Domain of unknown function, DUF529. This family represents a repeated region found in several Theileria parva proteins. The repeat is normally about 70 residues long and contains a conserved aromatic  residue in the middle. . 
+PF04409 Protein of unknown function (DUF530)<br>Family of hypothetical archaeal proteins.. 
+PF04407 Protein of unknown function (DUF531)<br>Family of hypothetical archaeal proteins.. 
+PF04391 Protein of unknown function (DUF533)<br>Some family members may be secreted or integral membrane proteins.. 
+PF04392 DUF534; <br>ABC transporter substrate binding protein. This family contains many hypothetical proteins and some ABC transporter substrate binding proteins.. 
+PF04393 Protein of unknown function (DUF535)<br>Family member Shigella flexneri VirK (Swiss:Q99QA5) is a virulence protein required for the expression, or correct membrane localisation of IcsA  (VirG) on the bacterial cell surface  ,  . This family also includes Pasteurella haemolytica lapB (Swiss:P32181),  which is thought to be membrane-associated.. 
+PF04394 Protein of unknown function, DUF536<br>Pfam-B_2107 (release 7.3). This family aligns the C-terminal region from several bacterial proteins of unknown function that may be involved in a theta-type replication mechanism.. 
+PF04398 Protein of unknown function, DUF538<br>Pfam-B_2637 (release 7.3). This family consists of several plant proteins of unknown function.. 
+PF04400 Protein of unknown function (DUF539)<br>Putative periplasmic protein.. 
+PF01877 DUF54;<br>PH1010 Swiss:O58738 is composed of five alpha-helices (1-5) and eight beta-strands (1-8) with the following topology: beta-1, alpha-1, beta-2, beta-3, alpha-2, alpha-3, beta-4, beta-5, alpha-4, beta-6, alpha-5, beta-7, beta-8. The first six beta-strands (1-6) form a slightly twisted antiparallel beta-sheet and face five alpha-helices on one side. The last two beta-strands form an antiparallel beta-sheet in the C-terminus. PH1010 forms a characteristic homodimer structure in the crystal.\.       Dimerisation of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5  . Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family  . Despite this, these proteins bind to double-stranded RNA in a non-sequence specific manner  .. 
+PF04402 DUF541; <br>Protein of unknown function (DUF541). Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries.  However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase).  SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity  . Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerisation. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics  . In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.. 
+PF04418 Domain of unknown function (DUF543)<br>This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long.  However the Arabidopsis homologue is over 300 residues long.  The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.. 
+PF04424 Protein of unknown function (DUF544)     <br>Eukaryotic protein of unknown function.. 
+PF04440 DUF546; <br>Dysbindin (Dystrobrevin binding protein 1). Pfam-B_3919 (release 7.5). Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localises with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane  . Genetic variation in the  human dysbindin gene is also thought to be associated with Schizophrenia  .. 
+PF04445 DUF548;<br>Putative SAM-dependent methyltransferase. This is a family of putative SAM-dependent methyltransferases.. 
+PF04446 DUF549; <br>tRNAHis guanylyltransferase. The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His  . The catalytic domain Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases,  diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system  . Thg1 possesses an active site with three  acidic residues that chelate Mg++ cations  . Thg1 catalyzes  polymerization similar to the 5'-3' polymerases   .. 
+PF01878 DUF55;<br>This domain was formerly known as DUF55.  Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding  .. 
+PF04447 Protein of unknown function (DUF550)<br>This family is found in a range of Proteobacteria and a few P-22 dsDNA virus particles. The function is currently not known.. 
+PF04448 Protein of unknown function (DUF551)   <br>This family represents the carboxy terminus of a protein of unknown  function, found in dsDNA viruses with no RNA stage, including  bacteriophages lambda and P22, and also in some Escherichia coli prophages.. 
+PF04472 Protein of unknown function (DUF552)<br>Family of uncharacterised proteins.. 
+PF04473 Transglutaminase-like domain<br>This family of uncharacterised archaeal proteins are related to Transglutaminase-like domains. This family has previously been called DUF553 and UPF0252.. 
+PF04474 Protein of unknown function (DUF554)<br>Family of uncharacterised prokaryotic proteins.  Multiple predicted transmembrane regions suggest that the region is membrane associated. . 
+PF04475 Protein of unknown function (DUF555)<br>Family of uncharacterised, hypothetical archaeal proteins. . 
+PF04476 Protein of unknown function (DUF556)<br>Family of uncharacterised, hypothetical prokaryotic proteins.. 
+PF04452 DUF558; <br>RNA methyltransferase. RNA methyltransferases modify nucleotides during ribosomal RNA maturation in a site-specific manner.  The Escherichia coli member is specific for U1498 methylation   .. 
+PF04480 Protein of unknown function (DUF559)<br>
+PF04575 Protein of unknown function (DUF560)<br>Pfam-B_4010 (release 7.5). Family of hypothetical bacterial proteins. . 
+PF04481 Protein of unknown function (DUF561)<br>Protein of unknown function found in a cyanobacterium, and the chloroplasts of algae.. 
+PF04763 Protein of unknown function (DUF562)<br>Pfam-B_6057 (release 7.5). Family of uncharacterised proteins.. 
+PF04577 Protein of unknown function (DUF563)<br>Pfam-B_4026 (release 7.5). Family of uncharacterised proteins.. 
+PF04483 Protein of unknown function (DUF565)<br>Predicted transmembrane protein found in plants, chloroplasts and cyanobacteria.  This family is also known as YCF20.. 
+PF04525 DUF567;<br>Pfam-B_4998 (release 7.5). The structure of this family has been solved. It comprises a 12-stranded beta barrel with a central C-terminal alpha helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein  . In plants it plays a role in defense against pathogens  .. 
+PF04601 Protein of unknown function (DUF569)<br>Pfam-B_4902 (release 7.5). Family of hypothetical proteins. Some family members contain a two copies of the region.. 
+PF01881 DUF57;<br>CRISPR associated protein Cas6. This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats  . It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation  . Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers  .. 
+PF04489 Protein of unknown function (DUF570)    <br>Protein of unknown function, found in herpesvirus and cytomegalovirus.. 
+PF04672 DUF574;<br>S-adenosyl methyltransferase. Pfam-B_4601 (release 7.5). This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw from Swiss:Q82L35 suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22 . The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).. 
+PF04746 Protein of unknown function (DUF575)<br>Pfam-B_6048 (release 7.5). Family of uncharacterised proteins.  Contains several chlamydial members. . 
+PF04507 Protein of unknown function, DUF576<br>Pfam-B_2120 (release 7.5). This family contains several uncharacterised staphylococcal proteins.. 
+PF04510 Family of unknown function (DUF577)<br>Pfam-B_3938 (release 7.5). Family of Arabidopsis thaliana proteins.  Many of these members contain a repeated region.. 
+PF04669 DUF579;<br>Polysaccharide biosynthesis. Pfam-B_4574 (release 7.5). This family of proteins plays a role in xylan biosynthesis in plant cell walls. Its precise role in xylan biosynthesis is unknown [1,2]. Its function in other organisms is unknown.. 
+PF01882 Protein of unknown function DUF58<br>This family of prokaryotic proteins have no known function. Swiss:P71138 a protein of unknown function in the family has been misannotated as alpha-dextrin 6-glucanohydrolase.. 
+PF04515 DUF580; <br>Plasma-membrane choline transporter. Mifsud W, Pollington J. Pfam-B_2258 (release 7.5). This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals  .. 
+PF04570 Protein of unknown function (DUF581)<br>Pfam-B_4765 (release 7.5). Family of uncharacterised proteins.. 
+PF04518 DUF582;<br>Effector from type III secretion system. Mifsud W, Eberhardt R. Pfam-B_2447 (release 7.5). This is a family of effector proteins which are secreted by the type III secretion system [1,2]. The precise function of this family is unknown.. 
+PF04519 DUF583;<br>Polymer-forming cytoskeletal. Pfam-B_2455 (release 7.5). This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localisation and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.. 
+PF04520 DUF584;<br>Senescence regulator. Pfam-B_2571 (release 7.5). This protein regulates the expression of proteins associated with leaf senescence in plants [1,2].. 
+PF04522 Protein of unknown function (DUF585)<br>This region represents the N terminus of bromovirus 2a protein, and is always found N terminal to a predicted RNA-dependent RNA polymerase region (Pfam:PF00978).. 
+PF04532 Protein of unknown function (DUF587)<br>This family consists of the N termini of some human herpesvirus U58 proteins, and some cytomegalovirus UL87 proteins. This region is always found N terminal to the Pfam family UL87 (Pfam:PF03043), which has no known function.. 
+PF04569 Protein of unknown function<br>Pfam-B_2799 (release 7.5). This family represents a conserved region in a number of uncharacterised plant proteins.. 
+PF04574 Protein of unknown function (DUF592)<br>This region is found in some SIR2 family proteins (Pfam:PF02146).. 
+PF04578 Protein of unknown function, DUF594<br>Pfam-B_2859 (release 7.5). 
+PF04591 Protein of unknown function, DUF596<br>Pfam-B_5061 (release 7.5). This family contains several uncharacterised proteins.. 
+PF04640 DUF597; <br>PLATZ transcription factor. Mifsud W, Riaño-Pachón D, Mistry J. Pfam-B_5458 (release 7.5). Plant AT-rich sequence and zinc-binding proteins (PLATZ) are zinc dependant DNA binding proteins.  They bind to AT rich sequences and functions in transcriptional repression  .. 
+PF04654 Protein of unknown function, DUF599<br>Pfam-B_5550 (release 7.5). This family includes several uncharacterised proteins.. 
+PF00892 DUF6;<br>EamA-like transporter family. Pfam-B_177 (release 3.0). This family includes many hypothetical membrane proteins of unknown function.\.       Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6.. 
+PF04634 Protein of unknown function, DUF600<br>Pfam-B_5411 (release 7.5). This conserved region is found in several uncharacterised proteins from Gram positive bacteria.. 
+PF04645 Protein of unknown function, DUF603<br>Pfam-B_5498 (release 7.5). This family includes several uncharacterised proteins from Borrelia species.. 
+PF04646 Protein of unknown function, DUF604<br>Pfam-B_5503 (release 7.5). This family includes a conserved region found in several uncharacterised plant proteins.. 
+PF04657 Protein of unknown function, DUF606<br>Pfam-B_5554 (release 7.5). This family includes several uncharacterised bacterial proteins.. 
+PF01886 Protein of unknown function DUF61<br>Protein found in Archaebacteria. These proteins have no known  function.. 
+PF04748 DUF610; div_psaccdeacet; <br>Divergent polysaccharide deacetylase. Pfam-B_5949 (release 7.5). This family is divergently related to Pfam:PF01522 (personal obs:Yeats C).. 
+PF04764 Protein of unknown function (DUF613)<br>Pfam-B_6084 (release 7.5). Family of chloroplast proteins of unknown function.  Some members have two copies of the conserved region.. 
+PF04751 Protein of unknown function (DUF615)<br>This family of bacterial proteins has no known function.. 
+PF04765 Protein of unknown function (DUF616)<br>Pfam-B_6152 (release 7.5). Family of uncharacterised proteins.. 
+PF04768 Protein of unknown function (DUF619)<br>This region of unknown function is found at the C-terminus of Neurospora crassa acetylglutamate synthase (amino-acid acetyltransferase, EC: 2.3.1.1) (Swiss:Q12643).  It is also found C-terminal to the amino acid kinase  region (Pfam:PF00696) in some fungal acetylglutamate kinase enzymes.. 
+PF01887 DUF62;<br>S-adenosyl-l-methionine hydroxide adenosyltransferase. This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme  . S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion  . This family used to be known as DUF62.. 
+PF04788 Protein of unknown function (DUF620)<br>Pfam-B_6213 (release 7.5). Family of uncharacterised proteins.. 
+PF04822 DUF622;<br>Mifsud W, Eberhardt R. Pfam-B_3835 (release 7.6). This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity  .. 
+PF04844 DUF623;<br>Transcriptional repressor, ovate. Mifsud W, Eberhardt R. Pfam-B_4487 (release 7.6). This is a family of transcriptional repressors. In plants, these proteins are important regulators of growth and development [1,2].. 
+PF04854 Protein of unknown function, DUF624<br>Pfam-B_4640 (release 7.6). This family includes several uncharacterised bacterial proteins.. 
+PF04776 Protein of unknown function (DUF626)<br>Pfam-B_2357 (release 7.6). Protein of unknown function, currently only identified in Brassicaceae.. 
+PF04781 Protein of unknown function (DUF627)<br>Pfam-B_2475 (release 7.6). This family represents the N-terminal region of several plant proteins of unknown function.. 
+PF04780 Protein of unknown function (DUF629)<br>Pfam-B_2475 (release 7.6). This family represents a region of several plant proteins of unknown  function. A C2H2 zinc finger is predicted in this region in some family members, but the spacing between the cysteine residues is not conserved throughout the family.. 
+PF01889 Membrane protein of unknown function DUF63<br>Proteins found in Archaebacteria of unknown function. These proteins are probably transmembrane proteins.. 
+PF04816 Family of unknown function (DUF633) <br>Pfam-B_5077 (release 7.6). This family of proteins are uncharacterised have no known function.. 
+PF04827 DUF635; <br>Plant transposon protein. Pfam-B_2859 (release 7.6). This family contains plant transposases which are putative members of the PIF / Ping-Pong family   .. 
+PF04828 DUF636; <br>Glutathione-dependent formaldehyde-activating enzyme. Pfam-B_2779 (release 7.6). 
+PF04830 Possible hemagglutinin (DUF637)<br>Pfam-B_2732 (release 7.6). This family represents a conserved region found in a bacterial protein which may be a hemagglutinin or hemolysin.. 
+PF04829 DUF638;<br>Pre-toxin domain with VENN motif. Pfam-B_2732 (release 7.6). This family represents a conserved region found in many bacterial porlymorphic toxins which is located before the C-terminal toxin modules   .. 
+PF04842 Plant protein of unknown function (DUF639)<br>Pfam-B_6010 (release 7.6). Plant protein of unknown function.. 
+PF04852 Protein of unknown function (DUF640)<br>Pfam-B_6053 (release 7.6). This family represents a conserved region found in plant  proteins including Resistance protein-like protein (Swiss:O49468).. 
+PF04862 Protein of unknown function (DUF642)<br>Pfam-B_4723 (release 7.6). This family represents a duplicated conserved region found in a number of uncharacterised plant proteins, potentially in the stem. There is a conserved CGP sequence motif.. 
+PF04867 Protein of unknown function (DUF643)<br>Pfam-B_6086 (release 7.6). Protein of unknown function found in Borrelia burgdorferi, the Lyme disease spirochete.. 
+PF04870 DUF644;<br>Mifsud W, Eberhardt R. Pfam-B_4889 (release 7.6). This family of proteins plays a role in the moulting cycle of nematodes, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle  .. 
+PF04875 Protein of unknown function, DUF645<br>Mifsud W, Eberhardt R, Haft D. Pfam-B_4997 (release 7.6). This family includes several uncharacterised proteins from Vibrio cholerae. There is some doubt regarding the existence of these proteins, they are encoded by open reading frames contained within a repeated region in the Vibrio superintegron.. 
+PF04883 DUF646;<br>Bacteriophage HK97-gp10, putative tail-component. Pfam-B_6160 (release 7.6). This family of proteins is found in the caudovirales.  It may be a tail component.. 
+PF04890 Family of unknown function (DUF648) <br>Pfam-B_5530 (release 7.6). Family of hypothetical Chlamydia proteins.  This family may well comprise of two domains, as some members only match the N-terminus. . 
+PF04894 Archaeal protein of unknown function (DUF650)<br>Pfam-B_6199 (release 7.6). This family represents the amino terminal region of an archaeal protein of unknown function.. 
+PF04895 Archaeal protein of unknown function (DUF651)<br>Pfam-B_6199 (release 7.6). This family represents the carboxy terminal region of an archaeal protein of unknown function.. 
+PF04910 DUF654;<br>Transcriptional repressor TCF25. Mifsud W, Eberhardt R. Pfam-B_6652 (release 7.6). Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions  .. 
+PF04919 Protein of unknown function (DUF655)<br>Pfam-B_6697 (release 7.6). This family includes several uncharacterised archaeal proteins. This protein appears to contain two HHH motifs.. 
+PF04920 Family of unknown function (DUF656) <br>Pfam-B_5777 (release 7.6). A family of hypothetical proteins from Beet necrotic yellow vein virus.. 
+PF04936 Protein of unknown function (DUF658)<br>Pfam-B_5062 (release 7.6). Protein of unknown function found in Lactococcus lactis bacteriophages.. 
+PF04937 Protein of unknown function (DUF 659)<br>Pfam-B_5061 (release 7.6). Transposase-like protein with no known function.. 
+PF04939 DUF660; <br>Ribosome biogenesis regulatory protein (RRS1). Pfam-B_6906 (release 7.6). This family consists of several eukaryotic ribosome biogenesis regulatory (RRS1) proteins. RRS1 is a nuclear protein that is essential for the maturation of 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae  .. 
+PF04978 Protein of unknown function (DUF664)<br>Pfam-B_5281 (release 7.6). This family is commonly found in Streptomyces coelicolor and is of unknown  function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.. 
+PF05006 Protein of unknown function (DUF666)<br>Pfam-B_5319 (release 7.6). This family contains several uncharacterised viral proteins.. 
+PF05018 Protein of unknown function (DUF667)<br>This family of proteins are highly conserved in eukaryotes. Some proteins in the family are annotated as transcription factors. However, there is currently no support for this in the literature.. 
+PF05003 Protein of unknown function (DUF668)<br>Pfam-B_4700 (release 7.6). Uncharacterised plant protein.. 
+PF05037 Protein of unknown function (DUF669)<br>Pfam-B_5014 (release 7.7). Members of this family are found in various phage proteins.. 
+PF05050 DUF672;<br>Methyltransferase FkbM domain. Pfam-B_5811 (release 7.7). This family has members from bacteria to human, and appears to be a methyltransferase.. 
+PF05054 Protein of unknown function (DUF673)<br>Pfam-B_5918 (release 7.7). Family of uncharacterised viral proteins.. 
+PF05056 Protein of unknown function (DUF674)<br>Pfam-B_5937 (release 7.7). This family is found in Arabidopsis thaliana and contains several uncharacterised proteins.. 
+PF05055 Protein of unknown function (DUF677)<br>Pfam-B_5920 (release 7.7). This family consists of AT14A like proteins from Arabidopsis thaliana. At14a has a small domain that has sequence similarities to integrins from fungi, insects and humans. Transcripts of At14a are found in all  Arabidopsis tissues and localises partly to the plasma membrane  .. 
+PF05077 Protein of unknown function (DUF678)<br>Pfam-B_6127 (release 7.7). This family contains several poxvirus proteins of unknown function.. 
+PF05078 Protein of unknown function (DUF679)<br>Pfam-B_6129 (release 7.7). This family contains several uncharacterised plant proteins.. 
+PF05079 Protein of unknown function (DUF680)<br>Pfam-B_6131 (release 7.7). This family contains several uncharacterised proteins which seem to be found exclusively in Rhizobium loti.. 
+PF05080 Protein of unknown function (DUF681)<br>Pfam-B_6137 (release 7.7). This family contains several uncharacterised beak and feather disease virus proteins.. 
+PF05081 Protein of unknown function (DUF682)<br>Pfam-B_6152 (release 7.7). This family consists if several uncharacterised baculovirus proteins.. 
+PF05082 DUF683;<br>Moxon SJ, Eberhardt R. Pfam-B_6161 (release 7.7). This family contains several uncharacterised bacterial proteins. These proteins are found in nitrogen fixation operons so are likely to play some role in this process. They consist of two alpha helices which are joined by a four residue linker. The helices form an antiparallel bundle and cross towards their termini. They are likely to form a rod-like dimer  . They have structural similarity to the regulatory protein Rop, Pfam:PF01815.. 
+PF05075 Protein of unknown function (DUF684)<br>Moxon SJ, Pollington J. Pfam-B_6081 (release 7.7). This family contains several uncharacterised proteins from Caenorhabditis elegans. The GO annotation suggests that the protein is involved in nematode larval development and has a positive regulation on growth rate.. 
+PF05085 Protein of unknown function (DUF685)<br>Pfam-B_6261 (release 7.7). This family consists of several uncharacterised proteins from Borrelia burgdorferi (Lyme disease spirochete). There is some evidence to suggest that the proteins may be outer surface proteins.. 
+PF05092 DUF686;<br>Pfam-B_6313 (release 7.7). This is a family of dsDNA Baculovirus proteins. It is required for the infectivity of the OBs or occlusion bodies. It is a structural protein of the ODV envelope required only in the first steps of per os larva infection, as viruses being produced in cells expressing the gene for this protein but not containing it in their genomes are able to produce successful infections. Baculoviruses are large DNA viruses that infect arthropods, mainly members of the order Lepidoptera. In their life cycle, they produce two kinds of particles, a budded, non-occluded virus (BV), which buds out of the infected cell and is responsible for the cell-to-cell transmission of the virus, and an occluded form, the occlusion body (OB), which is responsible for protecting the virus between encounters with larvae. A variable number of virions are included in the para-crystalline structure of the OB, mainly constituted by the virus-encoded polyhedrin protein; these virions are called occlusion body-derived virions or ODVs. . 
+PF05095 Protein of unknown function (DUF687)<br>Pfam-B_6321 (release 7.7). This family contains several uncharacterised Chlamydia proteins.. 
+PF05093 DUF689; <br>Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis. Pfam-B_6320 (release 7.7), Wood V. Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS)  .  CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis  . Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress  .. 
+PF05148 DUF691; Methyltransf_hyp; <br>Hypothetical methyltransferase. Pfam-B_6432 (release 7.7). This family consists of several uncharacterised eukaryotic proteins which  are related to methyltransferases Pfam:PF01209.. 
+PF05114 Protein of unknown function (DUF692)<br>Pfam-B_6476 (release 7.7). This family consists of several uncharacterised bacterial proteins.. 
+PF05113 Protein of unknown function (DUF693)<br>Pfam-B_6473 (release 7.7). This family consists of several uncharacterised proteins from Borrelia  burgdorferi (Lyme disease spirochete).. 
+PF05107 Family of unknown function (DUF694) <br>TIGRFAMs (release 2.0);. Family of hypothetical bacterial proteins.. 
+PF05117 Family of unknown function (DUF695) <br>TIGRFAMs (release 2.0);. Family of uncharacterised bacterial proteins.. 
+PF05128 Domain of unknown function (DUF697) <br>TIGRFAMs (release 2.0);. Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.. 
+PF01901 Protein of unknown function  DUF70<br>Archaebacterial proteins of unknown function. Members of this family may be transmembrane proteins. . 
+PF05142 Domain of unknown function (DUF702) <br>Members of this family are found in various putative zinc finger proteins.. 
+PF05152 Protein of unknown function (DUF705)<br>Pfam-B_6448 (release 7.7). This family contains several uncharacterised Baculovirus proteins. . 
+PF05153 Family of unknown function (DUF706) <br>Pfam-B_2804 (release 7.7). Family of uncharacterised eukaryotic function.  Some members have a described putative function, but a common theme is not evident.. 
+PF05212 Protein of unknown function (DUF707)<br>Pfam-B_6598 (release 7.7). This family consists of several uncharacterised proteins from Arabidopsis thaliana.. 
+PF05166 DUF709; <br>This family of proteins formerly called DUF709 includes the E. coli gene ycgL. Homologues of YcgL are found in gammaproteobacteria. The structure of this protein shows a novel alpha/beta/alpha sandwich structure  .. 
+PF01902 DUF71; ATP_bind4;<br>This family of proteins probably binds ATP. This domain is about 200 amino acids long with a strongly conserved motif SGGKD at the N terminus.In some members of this family e.g. Swiss:Q12429, this domain is associated with Pfam:PF01042. . 
+PF05164 DUF710; <br>Cell division protein ZapA. ZapA is a cell division protein which interacts with FtsZ.  FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related proteins early in the bacterial cell cycle.  The interaction of FtsZ with ZapA drives its polymerisation and promotes FtsZ filament bundling thereby contributing to the spatio-temporal tuning of the Z-ring   .. 
+PF05167 Uncharacterised ACR (DUF711)<br>The proteins in this family are functionally uncharacterised. The proteins are around 450 amino acids long. It is likely that this family represents a group of glycerol-3-phosphate dehydrogenases.. 
+PF05168 DUF712; <br>
+PF05206 DUF715; <br>Methyltransferase TRM13. Pfam-B_10143 (release 7.7). This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4  .  TRM13 shows no sequence similarity to other known methyltransferases.. 
+PF01904 Protein of unknown function DUF72<br>The function of this family is unknown.. 
+PF01905 DUF73;<br>CRISPR-associated negative auto-regulator DevR/Csa2. This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats  . It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation  . Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers  . This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system  .. 
+PF01906 DUF74;<br>Putative heavy-metal-binding. From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerises as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.. 
+PF01910 Domain of unknown function DUF77<br>Enright A, Ouzounis C, Cerutti L. Domain of unknown function.  The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is  likely to exists as at least homodimers.  Sulphate ions are  are located at the dimer interfaces, which are thought to confer additional stability.  Although the function of this domain remains to be identified, its structure suggests a role in  protein-protein interactions possibly regulated by the binding of small-molecule ligands  .. 
+PF01918 DUF78; <br>Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.. 
+PF01923 DUF80;<br>Cobalamin adenosyltransferase. Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation  .The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12  .. 
+PF01925 DUF81;<br>Sulfite exporter TauE/SafE. Enright A & Pfam-B_3578 (Release 7.5). This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane   during taurine metabolism as an exporter of sulfoacetate  . This family used to be known as DUF81.. 
+PF01927 DUF82;<br>RNAse domain of the PIN fold   with an inserted Zinc Ribbon at the C terminus  .. 
+PF01930 DUF83;<br>Domain of unknown function DUF83. This domain has no known function.  The domain contains three conserved cysteines at its C terminus.. 
+PF01931 DUF84;<br>Protein of unknown function DUF84. The function of this prokaryotic protein family is unknown.. 
+PF01934 Protein of unknown function DUF86<br>The function of members of this family is unknown.. 
+PF01935 Domain of unknown function DUF87<br>The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.. 
+PF01936 DUF88;<br>These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion, unlike the FLAP/5' --> 3' exonuclease superfamily, which binds two metal ions.  Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.. 
+PF01937 Protein of unknown function DUF89<br>This family has no known function.. 
+PF01939 Protein of unknown function DUF91<br>The function of this prokaryotic protein is unknown.. 
+PF01940 Integral membrane protein DUF92<br>Members of this family have several predicted transmembrane helices.  The function of these prokaryotic proteins is unknown.. 
+PF01941 DUF93; <br>S-adenosylmethionine synthetase (AdoMet synthetase). This family consists of several archaebacterial S-adenosylmethionine synthetase C(AdoMet synthetase or MAT) (EC 2.5.1.6). S-Adenosylmethionine (AdoMet) occupies a central role in the metabolism of all cells. The biological roles of AdoMet include acting as the primary methyl group donor, as a precursor to the polyamines, and as a progenitor of a 5'-deoxyadenosyl radical. S-Adenosylmethionine synthetase catalyses the only known route of AdoMet biosynthesis. The synthetic process occurs in a unique reaction in which the complete triphosphate chain is displaced from ATP and a sulfonium ion formed. MATs from various organisms contain ~400-amino acid polypeptide chains  . . 
+PF01944 Integral membrane protein DUF95<br>Members of this family have several predicted transmembrane regions.  The function of this family is unknown.. 
+PF01947 Protein of unknown function (DUF98)<br>This is a family of uncharacterised proteins.. 
+PF01949 Protein of unknown function DUF99<br>The function of this archaebacterial protein family is unknown.. 
+PF01207 UPF0034;<br>Dihydrouridine synthase (Dus). Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA.  Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae.  Most dihydrouridines are found in the D loop of t-RNAs.  The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap.  Dus 1 (Swiss:Q9HGN6) from Saccharomyces cerevisiae acts on pre-tRNA-Phe, while Dus 2 (Swiss:P53720) acts on pre-tRNA-Tyr and pre-tRNA-Leu.  Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD  .  Some family members may be targeted to the mitochondria and even have a role in mitochondria  .. 
+PF00692 dUTPase<br>Pfam-B_127 (release 2.1). dUTPase hydrolyses dUTP to dUMP and pyrophosphate.. 
+PF02670 1-deoxy-D-xylulose 5-phosphate reductoisomerase<br>This is a family of 1-deoxy-D-xylulose 5-phosphate reductoisomerases.  This enzyme catalyses the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH  . This reaction is part of the terpenoid biosynthesis pathway.. 
+PF00350 dynamin; <br>
+PF04912 Dynamitin <br>Pfam-B_5757 (release 7.6). Dynamitin is a subunit of the microtubule-dependent motor complex and in implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS)  .. 
+PF01221 Dynein light chain type 1 <br>
+PF00519 E1; <br>Papillomavirus helicase. Pfam-B_48 (release 1.0). This protein is a DNA helicase that is required for initiation of viral DNA replication.  This protein forms a complex with the E2 protein Pfam:PF00508.. 
+PF00122 E1-E2 ATPase<br>
+PF00676 E1_dehydrog; <br>Dehydrogenase E1 component. Pfam-B_117 (release 2.1). This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.. 
+PF00524 E1_N; <br>E1 Protein, N terminal domain. Pfam-B_98 (release 1.0). 
+PF00511 E2_C; <br>E2 (early) protein, C terminal. Pfam-B_87 (release 1.0). 
+PF00508 E2_N; <br>E2 (early) protein, N terminal. Pfam-B_76 (release 1.0). 
+PF02319 E2F/DP family winged-helix DNA-binding domain<br>Pfam-B_8420 (release 5.2). This family contains the transcription factor E2F and  its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a  homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows  that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.. 
+PF02817 e3_binding; <br>This family represents a small domain of the E2 subunit of 2-oxo-acid dehydrogenases responsible for the binding of the E3 subunit.. 
+PF00518 Early Protein (E6)<br>Pfam-B_57 (release 1.0). 
+PF00527 E7 protein, Early protein<br>Pfam-B_95 (release 1.0). 
+PF00563 DUF2; <br>Alignment kindly provided by SMART. This domain is found in diverse bacterial signaling proteins.  It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function  . The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site  .. 
+PF04157 EAP30/Vps36 family<br>Pfam-B_8830 (release 7.3);. This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking.  EAP30 is a subunit of the ELL complex.  The ELL is an 80-kDa RNA polymerase II transcription factor.  ELL interacts with three other proteins to form the complex known as ELL complex.  The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity  .. 
+PF01309 EAV_env_prot; <br>Equine arteritis virus small envelope glycoprotein . Pfam-B_656 (release 3.0). Equine arteritis virus small envelope glycoprotein (Gs) is a  class I transmembrane protein which adopts a number of different conformations. . 
+PF02905 EBNA1; <br>Epstein Barr virus nuclear antigen-1, DNA-binding domain. This domain has a ferredoxin-like fold.. 
+PF00378 Enoyl-CoA hydratase/isomerase family<br>This family contains a diverse set of enzymes including: Enoyl-CoA hydratase (Swiss:Q13011). Napthoate synthase (Swiss:P27290). Carnitate racemase (Swiss:P31551). 3-hydoxybutyryl-CoA dehydratase (Swiss:P52046). Dodecanoyl-CoA delta-isomerase (Swiss:P42126).. 
+PF04736 Eclosion hormone<br>Eclosion hormone is an insect neuropeptide that triggers the performance of ecdysis behaviour, which causes shedding of the old cuticle at the end of a molt  ,  .. 
+PF02963 Restriction endonuclease EcoRI<br>
+PF03974 Ecotin<br>Pfam-B_54504 (release 7.2). Ecotin is a broad range serine protease inhibitor, which forms homodimers. The C-terminal region contains the dimerisation motif  . Interestingly, the binding sites show a fluidity of protein contacts binding sites show a fluidity of protein contacts derived from ecotin's  innate flexibility in fitting itself to proteases while [4,5].. 
+PF00736 EF1BD; <br>EF-1 guanine nucleotide exchange domain. Pfam-B_488 (release 2.1). This family is the guanine nucleotide exchange domain of EF-1 beta and EF-1 delta chains.. 
+PF00647 EF1G_domain;<br>Elongation factor 1 gamma, conserved domain. 
+PF00889 Elongation factor TS<br>Pfam-B_1408 (release 3.0). 
+PF01132 Elongation factor P (EF-P) OB domain<br>
+PF04863 Alliinase EGF-like domain<br>Pfam-B_4527 (release 7.6). Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase (EC:4.4.1.4), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system. This family represents the  N-terminal EGF-like domain  .. 
+PF01303 Egg lysin (Sperm-lysin)<br>Pfam-B_1464 (release 3.0). Egg lysin creates a hole in the envelope of the egg thereby allowing  the sperm to pass through the envelope and fuse with the egg.. 
+PF00971 EIAV coat protein, gp90<br>Pfam-B_210 (release 3.0). Equine infectious anaemia (EIAV). EIAV belongs to the family Retroviridae. EIAV gp90 is hypervariable in the carboxyl-end region and more stable in the amino-end region.  This variability is a pathogenicity factor that allows the evasion of the host's immune response.. 
+PF01176 Translation initiation factor 1A / IF-1<br>This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.. 
+PF05091 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)<br>Pfam-B_6311 (release 7.7). This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery  . The gene coding for the protein has been implicated in cancer in mammals  .. 
+PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold<br>eIF5A, previously thought to be an initiation factor, has been shown to be required for peptide chain elongation in yeast  .. 
+PF01873 eIF5_eIF2B; <br>Domain found in IF2B/IF5. This family includes the N terminus of eIF-5 Swiss:P55010, and the C terminus of eIF-2 beta Swiss:P20042. This region corresponds to the whole of the archaebacterial eIF-2 beta homologue. The region contains a putative zinc binding C4 finger.. 
+PF01912 eIF6; <br>This family includes eukaryotic translation initiation factor 6 as well as presumed archaebacterial homologues.. 
+PF03608 PTS system enzyme II sorbitol-specific factor<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03609 PTS system sorbose-specific iic component<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03612 EIIBC-GUT; <br>Sorbitol phosphotransferase enzyme II N-terminus. TIGRFAMs, Griffiths-Jones SR, Yeats C. 
+PF03611 PTS system sugar-specific permease component<br>This family includes bacterial transmembrane proteins with a putative sugar-specific permease function, including and analogous to the IIC component of the PTS system. It has been suggested that this permease may form part of an L-ascorbate utilisation pathway, with proposed specificity for 3-keto-L-gulonate (formed by hydrolysis of L-ascorbate) . This family includes the IIC component of the galactitol specific GAT family PTS system.. 
+PF03613 PTS system mannose/fructose/sorbose family IID component<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04873 Ethylene insensitive 3<br>Pfam-B_4883 (release 7.6). Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence. . 
+PF03317 ELF protein<br>Pfam-B_3282 (release 6.5). This is a family of hypothetical proteins from cereal crops.. 
+PF02323 Egg-laying hormone precursor    <br>Pfam-B_953 (release 5.2). This family consists of egg-laying hormone (ELH) precursor and atrial gland peptides form little and California sea hare. The family also includes ovulation prohormone precursor from great pond snail. This family thus represents a conserved gastropoda ovulation and  egg production prohormone.  Note that many of the proteins present  are further cleaved to give individual peptides  . Neuropeptidergic bag cells of the marine mollusk Aplysia californica synthesise an egg-laying hormone (ELH) precursor protein which is  cleaved to generate several bioactive peptides including ELH,  bag cell peptides (BCP) and acidic peptide (AP)  .. 
+PF00964 Elicitin<br>Elicitins form a novel class of plant necrotic proteins which are secreted by Phytophthora and Pythium fungi, parasites of many economically important crops. These proteins induce leaf necrosis in infected plants and elicit an incompatible hypersensitive-like reaction, leading to the development of a systemic acquired resistance against a range of fungal and bacterial plant pathogens  .. 
+PF03789 ELK domain <br>Pfam-B_3136 (release 7.0). This domain is required for the nuclear localisation of these proteins  .  All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox Pfam:PF00046. . 
+PF01151 GNS1_SUR4; <br>Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and  sphingolipid synthesis  .  Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum.   Yeast ELO3 (Swiss:P40319) affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1  .. 
+PF02488 Merozoite Antigen<br>Pfam-B_924 (release 5.4). This family represents the immunodominant surface antigen of Theileria parasites including equi merozoite antigen-1 (EMA-1) and equi merozoite antigen-2 (EMA-2)  . The protein shows variation at a putative glycosylation site, a potential mechanism for host immune response evasion  .. 
+PF01105 emp24/gp25L/p24 family/GOLD<br>Pfam-B_803 (release 3.0). Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains.  This domain corresponds closely to the beta-strand rich GOLD domain described in  .\.  The GOLD domain is always found combined with lipid- or membrane-association domains  .. 
+PF04493 Endonuc_V; <br>Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents  .. 
+PF02945 endonuclease_7; <br>Recombination endonuclease VII. 
+PF04231 Endonuclease_I;<br>Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species.  It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown  .  Other family members are known to be extracellular  .  This family also includes a non-specific, Mg2+ activated ribonuclease precursor (Swiss:Q03091)  .. 
+PF04667 endosulfine; <br>cAMP-regulated phosphoprotein/endosulfine conserved region. Pfam-B_4454 (release 7.5). Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19.  Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism.  In both cases the region occupies the majority of the protein [1,2]. . 
+PF00322 endothelin; <br>
+PF00555 endotoxin; <br>This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.. 
+PF03944 endotoxin_C; <br>This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.. 
+PF03945 endotoxin_N; <br>delta endotoxin, N-terminal domain. This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.. 
+PF03272 Viral enhancin protein<br>Pfam-B_4236 (release 6.5). 
+PF03386 Early nodulin 93 ENOD93 protein<br>Pfam-B_2931 (release 6.6). 
+PF00113 enolase; <br>Enolase, C-terminal TIM barrel domain. 
+PF03952 enolase_N; <br>Enolase, N-terminal domain. 
+PF03735 ENT domain<br>This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts  with BRCA2. The N terminus of this protein is found to be  similar to other vertebrate and plant proteins of unknown function.  This domain has a completely conserved histidine residue that may be functionally important.. 
+PF01375 Enterotoxin_A; <br>Heat-labile enterotoxin alpha chain. 
+PF01376 Enterotoxin_B; <br>Heat-labile enterotoxin beta chain. 
+PF02048 Enterotoxin_HS;<br>Heat-stable enterotoxin ST. This family consists of the heat stable enterotoxin ST from Escherichia coli. ST is a small peptide of 18 or 19 amino acid residues produced by enterotoxigenic E. coli and is one of the causes of acute diarrhoea in infants and travellers in developing countries. ST triggers a biological response by binding to a membrane-associated guanylyl cyclase C which is located on intestinal epithelial cell membranes  .. 
+PF01417 ENTH domain<br>The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery.  The function of the ENTH domain is unknown.. 
+PF00429 ENV_polyprotein; <br>ENV polyprotein (coat polyprotein). Pfam-B_145 (release 1.0). 
+PF00811 Ependymin<br>Pfam-B_1391 (release 2.1). 
+PF01404 EPH_lbd; <br>Ephrin receptor ligand binding domain. The Eph receptors, which bind to ephrins Pfam:PF00812 are a large family of receptor tyrosine kinases.  This family represents the amino terminal domain which binds the ephrin ligand  .. 
+PF01370 NAD dependent epimerase/dehydratase family<br>Pfam-B_93 (release 3.0). This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.. 
+PF02350 UDP-N-acetylglucosamine 2-epimerase<br>Pfam-B_888 (release 5.2) & Pfam-B_4862 (Release 7.5). This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc.  Note that some of the enzymes is this family are bifunctional such as Swiss:O35826 and Swiss:Q9Z0P6 in this instance Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of Swiss:O35826 is the kinase domain  .. 
+PF00758 Erythropoietin/thrombopoietin<br>Pfam-B_990 (release 2.1). 
+PF00275 EPSP_syntase; <br>EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase). 
+PF03736 EPTP domain<br>Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section.  The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold  .. 
+PF01133 Enhancer of rudimentary<br>Enhancer of rudimentary is a protein of unknown function that is highly conserved in plants and animals. This protein is found to be an enhancer of the rudimentary gene Swiss:P05990.. 
+PF00810 ER lumen protein retaining receptor<br>Pfam-B_1387 (release 2.1). 
+PF02732 ERCC4 domain<br>This domain is a family of nucleases. The family includes EME1 which is an essential component of a Holliday junction resolvase [2-3].  EME1 interacts with MUS81 to form a DNA structure-specific endonuclease.. 
+PF04404 ERF superfamily<br>The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to ERF  .. 
+PF03463 eRF1 domain 1<br>The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known  . The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site  . This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.. 
+PF03464 eRF1 domain 2<br>The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known  . The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site  . This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.. 
+PF03465 eRF1 domain 3<br>The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known  . The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site  . This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.. 
+PF03734 ErfK_YbiS_YhnG; <br>L,D-transpeptidase catalytic domain. This family of proteins are found in a range of bacteria. It has been shown that this domain can act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking  .  This gives bacteria resistance to beta-lactam antibiotics that inhibit PBPs which usually carry out the cross-linking reaction.  The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.  Several members of this family contain peptidoglycan binding domains.  The molecular structure of YkuD protein shows this domain has a novel tertiary fold consisting of a beta-sandwich with two mixed sheets, one containing five strands and the other, six strands. The two beta-sheets form a cradle capped by an alpha-helix. This family was formerly called the ErfK/YbiS/YcfS/YnhG family, but is now named after the first protein of known structure.. 
+PF03694 UPF0143; <br>This is a family of integral membrane proteins, which may contain four  transmembrane helices.  Members of this family are thought to be involved  in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p  (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the  endoplasmic reticulum or may facilitate interaction between these proteins  .  The family contains a conserved arginine and histidine that may be  functionally important.. 
+PF04622 ERG2 and Sigma1 receptor like protein<br>This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyses a  reaction in ergosterol biosynthesis, which results in unsaturation at C-7  in the B ring of sterols  . Sigma 1 receptor is a low molecular mass mammalian protein located in the  endoplasmic reticulum  , which interacts with endogenous steroid  hormones, such as progesterone and testosterone  .  It also binds the  sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine  .   Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA  receptor function, the alpha-adrenergic system and opioid analgesia.. 
+PF01222 Ergosterol biosynthesis ERG4/ERG24 family<br>
+PF00769 Ezrin/radixin/moesin family<br>Pfam-B_851 (release 2.1). This family of proteins contain a band 4.1 domain (Pfam:PF00373), at their amino terminus.  This family represents the rest of these proteins.. 
+PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)<br>Pfam-B_4729 (release 7.3);. Members of this family are required for the formation of disulphide bonds in the ER [1,2].. 
+PF03238 ESAG protein<br>Pfam-B_3037 (release 6.5). Expression-site-associated gene (ESAG) proteins are thought  to be involved in VSG activation. This family includes ESAG 117A Swiss:P04477 as well as ESAG IM Swiss: Q26705.. 
+PF03433 ESPA; <br>EspA-like secreted protein . Pfam-B_4100 (release 6.6). EspA is the prototypical member of this family. EspA, together with EspB, EspD and Tir are exported by a type III secretion system.  These proteins are essential for attaching and effacing lesion formation. EspA is a structural protein and a major component of a large, transiently expressed, filamentous surface organelle which forms a direct link between the bacterium and the host cell [1,2].. 
+PF04806 EspF protein repeat<br>Pfam-B_3518 (release 7.6). The enteropathogenic Escherichia coli EspF secreted protein induces host cell apoptosis. Its proline-rich structure suggests that it may act by binding to SH3 domains or EVH1 domains of host cell signalling proteins  . . 
+PF00756 Putative esterase<br>Pfam-B_476 (release 2.1) & Pfam-B_4968 (Release 7.5). This family contains Esterase D Swiss:P10768. However it is not clear if all members of the family have the same function.  This family is related to the Pfam:PF00135 family.. 
+PF01684 ET module<br>This domain has no known function. It is found in several C. elegans proteins. The domain contains 8-10 conserved cysteines that probably form 4-5 disulphide bridges. By inspection of the conservation of cysteines it looks like cysteines 1,2,3,4,9 and 10 are always present and that sometimes the pair 5 and 8 or the pair 6 and 7 are missing. This suggests that cysteines 5/8 and 6/7 make disulphide bridges. . 
+PF00766 Electron transfer flavoprotein FAD-binding domain<br>Pfam-B_853 (release 2.1) & Pfam-B_1321 (release 3.0). This domain found at the C-terminus of electron transfer flavoprotein alpha chain and binds to FAD  . The fold consists of a five-stranded parallel beta sheet as the core of the domain, flanked by alternating helices.  A small part of this domain is donated by the beta chain  .. 
+PF01012 ETF_beta; <br>Electron transfer flavoprotein domain. Pfam-B_1321 (release 3.0). This family includes the homologous domain shared between the alpha and beta subunits of the electron transfer flavoprotein  .. 
+PF05187 ETFD; <br>Electron transfer flavoprotein-ubiquinone oxidoreductase. Pfam-B_2305 (release 7.7). Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4Fe4S] cluster, are present in a 64-kDa monomer  . . 
+PF00178 Ets-domain<br>
+PF03318 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2<br>Pfam-B_3569 (release 6.5). This family appears to be distantly related to Pfam:PF01117.. 
+PF01459 Euk_porin; <br>Prodom_3211 (release 99.1) & Pfam-B__3211 (release 7.5). 
+PF04346 Ethanolamine utilisation protein, EutH<br>EutH is a bacterial membrane protein whose molecular function is unknown. It has been suggested that it may act as an ethanolamine transporter, responsible for carrying ethanolamine from the periplasm to the cytoplasm  .. 
+PF03319 Ethanolamine utilisation protein EutN/carboxysome<br>Pfam-B_3053 (release 6.5). The crystal structure of EutN contains a central five-stranded beta-barrel, with an alpha-helix at the open end of this barrel (PDB:2HD3). The structure also contains three additional beta-strands, which help the formation of a tight hexamer, with a hole in the center. this suggests that EutN forms a pore, with an opening of 26 Angstrom in diameter on one face and 14 Angstrom on the other face  . EutN is involved in the cobalamin-dependent degradation of ethanolamine  .. 
+PF02472 Biopolymer transport protein ExbD/TolR<br>Pfam-B_2343 (release 5.4). This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria  . The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various  receptor bound substrates including colicins  .. 
+PF01541 Exci_endo_N; <br>GIY-YIG catalytic domain. Pfam-B_489 (release 4.0). This domain called GIY-YIG is found in the amino terminal region of excinuclease abc subunit c (uvrC), bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage.  The structure of I-TevI a GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices  . The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site.. 
+PF03081 Exo70 exocyst complex subunit<br>Pfam-B_2462 (release 6.4). The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae  , Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast  . Exo70 interacts with the Rho3 GTPase  . This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud)  . In humans, the functions of Exo70 and the exocyst complex are less well characterised: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis  .. 
+PF04257 Exodeoxyribonuclease V, gamma subunit <br>TIGRFAMs (release 2.0);. The Exodeoxyribonuclease V enzyme is a multi-subunit enzyme comprised of the proteins RecB, RecC (this family) and  RecD.  This enzyme plays an important role in homologous genetic recombination, repair of double strand DNA breaks resistance to UV irradiation and chemical DNA-damage. The enzyme (EC:3.1.11.5) catalyses ssDNA or dsDNA-dependent ATP hydrolysis, hydrolysis of ssDNA or dsDNA and unwinding of dsDNA  . This family consists of two AAA domains.. 
+PF02601 Exonuclease_VII; <br>Exonuclease VII, large subunit. This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones  .. 
+PF02095 Extensin; <br>Extensin-like protein repeat. 
+PF01267 F-actin capping protein alpha subunit<br>
+PF00469 Negative factor, (F-Protein) or Nef<br>Pfam-B_128 (release 1.0). Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to  bind specifically to a subset of the Src kinase family.. 
+PF03807 NADP oxidoreductase coenzyme F420-dependent<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01115 F-actin capping protein, beta subunit<br>
+PF01116 Fructose-bisphosphate aldolase class-II<br>
+PF03405 Fatty acid desaturase<br>
+PF04116 Fatty_acid_hyrd; <br>Fatty acid hydroxylase superfamily. Pfam-B_7847 (release 7.3) & DOMO:DM04600 & Pfam-B_905 (release 4.1);. This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases.  Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways  .  This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif.  Members of this family are integral membrane proteins.. 
+PF02504 Fatty acid synthesis protein<br>Pfam-B_1671 (release 5.4). The plsX gene is part of the bacterial fab gene cluster which encodes several key fatty acid biosynthetic enzymes  . The exact function of the plsX protein in fatty acid synthesis is unknown.. 
+PF01557 Fumarylacetoacetate (FAA) hydrolase family<br>Pfam-B_641 (release 4.0) & Pfam-B_1228 (release 4.1). This family consists of fumarylacetoacetate (FAA) hydrolase,  or fumarylacetoacetate hydrolase (FAH) and it also includes  HHDD isomerase/OPET decarboxylase from E. coli strain W.    FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses  fumarylacetoacetate into fumarate and acetoacetate which then join the  citric acid cycle  . Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to  liver cirrhosis, hepatocellular carcinoma, renal tubular damages and  neurologic crises amongst other symptoms  . The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites  . The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED.  The final products of this pathway are pyruvic acid and succinic  semialdehyde. This family also includes various hydratases and 4-oxalocrotonate  decarboxylases which are involved in the bacterial meta-cleavage  pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli Swiss:P77608 is involved in the phenylpropionic acid pathway of E. coli and catalyses the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor  . OHED hydratase encoded by hpcG in E. coli Swiss:P42270 is involved  in the homoprotocatechuic acid (HPC) catabolism  . XylI in P. putida Swiss:P49155 is a 4-Oxalocrotonate decarboxylase  .. 
+PF00667 FAD_binding; <br>Pfam-B_180 (release 2.1). This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.. 
+PF00890 FAD binding domain<br>Pfam-B_255 (release 3.0). This family includes members that bind FAD.  This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.. 
+PF01494 FAD binding domain<br>Pfam-B_549 (release 4.0). This domain is involved in FAD binding in a number of enzymes.. 
+PF00941 dehydrog_molyb; <br>FAD binding domain in molybdopterin dehydrogenase. Pfam-B_1112 (release 3.0). 
+PF01687 FAD_Synth; <br>Pfam-B_1221 (release 4.1). This family represents the C-terminal region of the bifunctional riboflavin biosynthesis protein known as RibC in Bacillus subtilis.  The RibC protein from Bacillus subtilis has both flavokinase and flavin adenine dinucleotide synthetase (FAD-synthetase) activities. RibC plays an essential role in the flavin metabolism  .  This domain is thought to have kinase activity  .. 
+PF04703 FaeA-like protein<br>Pfam-B_5784 (release 7.5). This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase [1,2].. 
+PF02106 Fanconi; <br>Fanconi anaemia group C protein. 
+PF03511 Fanconia; <br>Fanconi anaemia group A protein. 
+PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain<br>Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges  .. 
+PF04750 FAR-17a/AIG1-like protein<br>Pfam-B_3664 (release 7.5). This family includes the hamster androgen-induced FAR-17a protein (Swiss:Q60534)  ,  and its human homologue, the AIG1 protein (Swiss:Q9NVV5)  . The function of these proteins is unknown. This family also includes homologous regions from a number of other metazoan proteins.. 
+PF01581 FMRFamide related peptide family<br>Pfam-B_666 (release 4.1). The neuroactive peptide Phe-Met-Arg-Phe-NH2 (FMRF-amide) has a variety of effects on both mammalian and invertebrate tissues  .. 
+PF02469 Fasciclin domain<br>Pfam-B_562 (release 5.4). This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria  .. 
+PF02259 FAT domain<br>(Keith and Schreiber, Science 270:50). The FAT domain is named after FRAP, ATM and TRRAP.. 
+PF02260 FATC domain<br>(Keith and Schreiber, Science 270:50). The FATC domain is named after FRAP, ATM, TRRAP C-terminal  . The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability  .. 
+PF00316 Fructose-1-6-bisphosphatase<br>
+PF03320 Bacterial fructose-1,6-bisphosphatase, glpX-encoded<br>Pfam-B_3515 (release 6.5). 
+PF02634 FdhD/NarQ family<br>A pan-bacterial lineage of proteins. Nitrate assimilation protein,  NarQ,   and FdhD (Swiss:P32177) are required for formate  dehydrogenase activity. Structurally, they possess a deaminase fold with a characteristic binding pocket, suggesting that they  might bind a nucleotide or related molecule allosterically to  regulate the formate dehydrogenase catalytic subunit  .. 
+PF04216 Protein involved in formate dehydrogenase formation<br>The function of these proteins is unknown. They may possibly be involved in the formation of formate dehydrogenase.. 
+PF03147 Ferredoxin-fold anticodon binding domain<br>This is the anticodon binding domain found in some phenylalanyl tRNA synthetases.  The domain has a ferredoxin fold [1,2].. 
+PF00465 Iron-containing alcohol dehydrogenase <br>
+PF02742 Iron dependent repressor, metal binding and dimerisation domain<br>This family includes the Diphtheria toxin repressor.. 
+PF01325 Iron dependent repressor, N-terminal DNA binding domain<br>This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.. 
+PF02906 Iron only hydrogenase large subunit, C-terminal domain<br>
+PF02256 Iron hydrogenase small subunit<br>Pfam-B_3750 (release 5.2). This family represents the small subunit of the Fe-only hydrogenases EC:1.18.99.1. The subunit is comprised of alternating random coil and alpha helical structures that encompasses the large subunit in a novel protein fold  .. 
+PF01032 FecCD_family;<br>FecCD transport family. Pfam-B_377 (release 3.0). This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.. 
+PF04773 FecR protein<br>Pfam-B_3234 (release 7.5). FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognises iron dicitrate in the periplasm.. 
+PF02388 FemAB family<br>Pfam-B_1214 (release 5.2). The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan  . These proteins are also considered as a factor influencing the level of methicillin resistance  .. 
+PF04023 FeoA domain<br>This family includes FeoA a small protein, probably involved in Fe2+ transport  . This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators.  This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.. 
+PF02421 FeoB; <br>Ferrous iron transport protein B. Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions  . FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent  .. 
+PF00142 fer4_NifH; <br>4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family. 
+PF01794 Ferric reductase like transmembrane component<br>Pfam-B_728 (release 4.2). This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane  . The Frp1 protein Swiss:Q04800 from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake  . Cytochrome B-245 heavy chain Swiss:P04839 is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants  . Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterised by the absence of a functional plasma membrane associated NADPH oxidase  .  The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease  .. 
+PF00762 Ferrochelatase<br>Pfam-B_879 (release 2.1). 
+PF04060 Putative Fe-S cluster<br>This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.. 
+PF02941 FeThRed; FeThRed_beta; <br>Ferredoxin thioredoxin reductase variable alpha chain. 
+PF02943 FeThRed_alpha; <br>Ferredoxin thioredoxin reductase catalytic beta chain. 
+PF01846 FF domain<br>This domain has been predicted to be involved in protein-protein interaction  . This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions  .. 
+PF05013 N-formylglutamate amidohydrolase<br>Formylglutamate amidohydrolase (FGase) catalyses the terminal reaction in the five-step pathway for histidine utilisation in Pseudomonas putida. By this action, N-formyl-L-glutamate (FG) is hydrolysed to produce L-glutamate plus formate  .. 
+PF00167 Fibroblast growth factor<br>Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans  . Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors.  These receptors can each bind several different members of this family.  Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular  . They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms  .. 
+PF00370 FGGY; <br>FGGY family of carbohydrate kinases, N-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.. 
+PF02782 FGGY family of carbohydrate kinases, C-terminal domain<br>This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.. 
+PF00498 FHA domain<br>The FHA (Forkhead-associated) domain is a phosphopeptide binding motif  .. 
+PF00771 FHIPEP family<br>Pfam-B_983 (release 2.1). 
+PF01269 Fibrillarin<br>
+PF00147 fibrinogen_C; <br>Fibrinogen beta and gamma chains, C-terminal globular domain. 
+PF03516 Filaggrin<br>
+PF00038 filament; <br>Intermediate filament protein. 
+PF04732 filament_head; <br>Intermediate filament head (DNA binding) region. This family represents the N-terminal head region of intermediate  filaments.  Intermediate filament heads bind DNA  .  Vimentin heads are  able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis  .   Phosphorylation of the head region can affect filament stability  .  The head has been shown to interaction with the rod domain of the same protein  .. 
+PF00630 Filamin/ABP280 repeat<br>
+PF01611 Filovirus glycoprotein<br>Pfam-B_1023 (release 4.1). This family includes an extracellular region from the envelope glycoprotein of Ebola and Marburg viruses. This region is also produced as a separate transcript that gives rise to a non-structural, secreted glycoprotein, which is produced in large amounts and has an unknown function  . Processing of this protein may be involved in viral pathogenicity  .. 
+PF02097 Filoviridae VP35<br>
+PF00419 Fimbrial protein<br>Pfam-B_196 (release 1.0) & Jackhmmer:B2PIN3. 
+PF04449 CS1 type fimbrial major subunit<br>Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia  . The major subunit of CS1 pili is called CooA.  Periplasmic CooA is mostly complexed with the assembly protein CooB.  In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown  . A member of this family has also been identified in Salmonella typhi and Salmonella enterica  .. 
+PF02432 Fibrimal; <br>Fimbrial, major and minor subunit. Pfam-B_2036 (release 5.4). Fimbriae (also know as pili) are polar filaments found on the bacterial surface, allowing colonisation of the host. This family consists of the minor and major fimbrial subunits.. 
+PF05182 Fip1 motif<br>Pfam-B_4652 (release 7.7). This short motif is about 40 amino acids in length.  In the Fip1 protein that is a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase  . This region of Fip1 is needed for the interaction with the Th1 subunit of the complex and for specific polyadenylation of the cleaved mRNA precursor  .. 
+PF02433 Cytochrome C oxidase, mono-heme subunit/FixO<br>Pfam-B_2045 (release 5.4). The bacterial oxidase complex, fixNOPQ or cytochrome cbb3, is thought to be required for respiration in endosymbiosis. FixO is a membrane bound mono-heme constituent of the fixNOPQ complex.. 
+PF01346 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase<br>Pfam-B_402 (release 3.0). This family is only found at the amino terminus of Pfam:PF00254. This domain is of unknown function.. 
+PF04620 Flagellar filament outer layer protein Flaa<br>Periplasmic flagella are the organelles of spirochete mobility, and are structurally different from the flagella of other motile bacteria. They reside inside the cell within the periplasmic space, and confer mobility in viscous gel-like media such connective tissue  . The flagella are composed of an outer sheath of FlaA proteins and a core filament of FlaB proteins. Each species usually has several FlaA protein species  .. 
+PF03646 FlaG protein<br>Pfam-B_2985 (release 7.0). Although important for flagella the exact function of this protein is unknown.. 
+PF03614 Repressor of phase-1 flagellin<br>
+PF05149 Paraflagellar rod protein<br>Pfam-B_6464 (release 7.7). This family consists of several eukaryotic paraflagellar rod component proteins. The eukaryotic flagellum represents one of the most complex macromolecular structures found in any organism and contains more than 250 proteins  . In addition to its locomotive role, the flagellum is probably involved in nutrient uptake since receptors for host low-density lipoproteins are localised on the flagellar membrane as well as on the flagellar pocket membrane  .. 
+PF00700 Bacterial flagellin C-terminal helical region<br>Pfam-B_41 (release 2.1). Flagellins polymerise to form bacterial flagella.\.     There is some similarity between this family and Pfam:PF00669, particularly the motif NRFXSXIXXL. It has been suggested that these two regions associate   and this is shown to be correct as structurally this family forms an extended helix that interacts with Pfam:PF00700.. 
+PF00669 Bacterial flagellin N-terminal helical region<br>Pfam-B_37 (release 2.1). Flagellins polymerise to form bacterial flagella. This family includes flagellins and hook associated protein 3. Structurally this family forms an extended helix that interacts with Pfam:PF00700.. 
+PF01350 Flavivirus non-structural protein NS4A<br>Pfam-B_211 (release 3.0). Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning regions  .  NS4A has only been found in cells infected by Kunjin virus  .. 
+PF01349 Flavivirus non-structural protein NS4B<br>Pfam-B_211 (release 3.0). Flaviviruses encode a single polyprotein.\.      This is cleaved into three structural and seven non-structural proteins. The NS4B protein is small and poorly conserved among the Flaviviruses. NS4B contains multiple hydrophobic potential membrane spanning regions  .  NS4B may form membrane components of the viral replication complex and could be involved in membrane localisation of NS3 and Pfam:PF00972  .. 
+PF00972 Flavivirus RNA-directed RNA polymerase<br>Pfam-B_200 (release 3.0). Flaviviruses produce a polyprotein from the ssRNA genome. This protein is also known as NS5. This RNA-directed RNA polymerase possesses a number of short regions and motifs homologous to other RNA-directed RNA polymerases  .. 
+PF01570 Flavivirus polyprotein propeptide<br>Pfam-B_304 (release 4.1). The flaviviruses are small enveloped animal viruses containing a single positive strand genomic RNA  .  The genome encodes one large ORF a polyprotein which undergos proteolytic processing into mature viral  peptide chains. This family consists of a propeptide region of approximately 90 amino acid length.. 
+PF02525 NADHdh_2; <br>Flavodoxin-like fold. Pfam-B_1456 (release 5.4). This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2.  These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species  .\.     This enzyme uses a FAD co-factor.  The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy  . The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP  . This family is related to Pfam:PF03358 and Pfam:PF00258.. 
+PF02441 Flavoprotein<br>Pfam-B_1622 (release 5.4). This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD Swiss:P30197, which has been shown to be a flavoprotein that binds FMN  . This enzyme catalyses the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance  . dipicolinate synthase catalyses the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase Swiss:P33751 (EC:4.1.1.-)  .. 
+PF00460 flg_bb_rod; <br>Flagella basal body rod protein. 
+PF02120 Flagellar hook-length control protein FliK<br>This is the C terminal domain of FliK. FliK controls the length of the flagellar hook by directly measuring the hook length as a molecular ruler  .  This family also includes YscP of the Yersinia type III secretion system, and equivalent proteins in other pathogenic bacterial type III secretion systems.. 
+PF03963 Flagellar hook capping protein - N-terminal region<br>FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum  . It appears to act as a hook-capping protein to enable assembly of hook protein subunits  .  FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerisation and also plays a role in determination of the correct hook length, with the help of the FliK protein  .  This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallisation  .. 
+PF02107 Flagellar L-ring protein<br>
+PF02119 Flagellar P-ring protein<br>
+PF04316 Anti-sigma-28 factor, FlgM<br>FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis.  Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28.  All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium (Swiss:P26477).  The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery  .. 
+PF05130 FlgN protein<br>This family includes the FlgN protein and export chaperone involved in flagellar synthesis  .. 
+PF02465 Flagellar hook-associated protein 2 N-terminus<br>The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria  . This alignment covers the N-terminal region of this family of proteins.. 
+PF02049 Flagellar hook-basal body complex protein FliE<br>
+PF01706 FliG-C; <br>FliG C-terminal domain. FliG is a component of the flageller rotor, present in about 25 copies per flagellum.  This domain functions specifically in motor rotation.. 
+PF02108 Flagellar assembly protein FliH<br>
+PF02050 Flagellar FliJ protein<br>
+PF03748 Flagellar basal body-associated protein FliL<br>This FliL protein controls the rotational direction of the flagella during chemotaxis  . FliL is a cytoplasmic membrane protein associated with the basal body  .. 
+PF02154 Flagellar motor switch protein FliM<br>
+PF04347 Flagellar biosynthesis protein, FliO<br>FliO is an essential component of the flagellum-specific protein export apparatus  . It is an integral membrane protein. Its precise molecular function is unknown.. 
+PF00813 FliP family<br>Pfam-B_1679 (release 2.1). 
+PF02561 Flagellar protein FliS<br>FliS is coded for by the FliD operon and is transcribed in conjunction with FliD and FliT, however this protein has no known function.. 
+PF01698 Floricaula / Leafy protein<br>Pfam-B_1633 (release 4.1). This family consists of various plant development proteins which are homologues of floricaula (FLO)  and Leafy (LFY) proteins which are floral meristem identity proteins. Mutations in the sequences of these proteins affect  flower and leaf development.. 
+PF00624 Flocculin repeat<br>Pfam-B_51 (release 2.1). This short repeat is rich in serine and threonine residues.. 
+PF05202 Recombinase Flp protein<br>
+PF04964 Flp/Fap pilin component<br>
+PF03930 Flp;<br>Recombinase Flp protein N-terminus. 
+PF02662 Methyl-viologen-reducing hydrogenase, delta subunit<br>This family consist of methyl-viologen-reducing hydrogenase, delta subunit / heterodisulphide reductase.  No specific functions have been assigned to this  subunit.  The aligned region corresponds to almost the entire delta chain sequence and contains 4 conserved cysteine residues.  However, in  two Archaeoglobus sequences this region corresponds to only the C-terminus of these proteins Swiss:O29030 and Swiss:029595.. 
+PF02947 flt3_lig; <br>The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.. 
+PF04772 Influenza B matrix protein 2 (BM2)<br>Pfam-B_2165 (release 7.6). M2 is synthesised in the late phase of infection and incorporated into the virion.  It may be phosphorylated in vivo.  The function of BM2 is unknown  .. 
+PF02942 Influenza B non-structural protein (NS1)<br>Pfam-B_198 (Release 6.4). A specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 Swiss:Q64339 to its target proteins both in vitro and in infected cells. Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most predominant. Influenza A virus employs a different strategy: its NS1 protein does not bind the ISG15 protein, but little or no ISG15 protein is produced during infection  .. 
+PF03506 Influenza C non-structural protein (NS1)<br>Pfam-B_980 (release 7.0). The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment  encodes a 286 amino acid  non-structural protein NS1  . This protein contains 6 conserved cysteines that may be functionally important, perhaps binding to a metal ion.. 
+PF03555 Influenza C non-structural protein (NS2)<br>Pfam-B_346 (release 7.0). The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment  encodes a 286 amino acid  non-structural protein NS1 Pfam:PF03506 as well as the NS2 protein. The NS2 protein is only about 60 amino acids in length and of unknown function.. 
+PF00598 Influenza Matrix protein (M1)<br>This protein forms a continuous shell on the inner side of the lipid bilayer, but its function is unclear.. 
+PF00599 Influenza Matrix protein (M2)<br>This protein spans the viral membrane with an extracellular amino-terminus external and a cytoplasmic carboxy-terminus.. 
+PF00506 flu_virus_nuc;<br>Influenza virus nucleoprotein. Pfam-B_10 (release 1.0). 
+PF00600 Influenza non-structural protein (NS1)<br>NS1 is a homodimeric RNA-binding protein that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.. 
+PF00601 Influenza non-structural protein (NS2)<br>NS2 may play a role in promoting normal replication of the genomic RNAs by preventing the replication of short-length RNA species  . . 
+PF00603 Influenza RNA-dependent RNA polymerase subunit PA<br>
+PF00602 Influenza RNA-dependent RNA polymerase subunit PB1<br>Two GTP binding sites exist in this protein  .. 
+PF00604 Influenza RNA-dependent RNA polymerase subunit PB2<br>PB2 can bind 5' end cap structure of RNA  .. 
+PF03069 Acetamidase/Formamidase family<br>Pfam-B_2541 (release 6.4). This family includes amidohydrolases of formamide EC:3.5.1.49 and acetamide. Swiss:Q50228 forms a homotrimer suggesting all the members of this family also do.. 
+PF01070 FMN-dependent dehydrogenase<br>Pfam-B_829 (release 3.0). 
+PF00743 Flavin-binding monooxygenase-like<br>Pfam-B_437 (release 2.1). 
+PF00039 Fibronectin type I domain<br>Swissprot_feature_table. 
+PF00040 Fibronectin type II domain<br>
+PF00041 Fibronectin type III domain<br>Swissprot_feature_table. 
+PF02986 Fibronectin binding repeat<br>Griffiths-Jones SR, Schwarz-Linek U. Pfam-B_2661 (release 6.4). The ability of bacteria to bind fibronectin is thought to enable the colonisation of wound tissue and blood clots.  The fibronectin binding repeat is found in bacterial fibronectin binding proteins and serum opacity factor.  Bacterial fibronectin binding proteins are surface proteins that covalently link to the bacterial cell wall, mediate adherence of the bacteria to host cells   and trigger the fibronectin/integrin-mediated uptake of bacteria by host cells  . Each fibronectin binding repeat is an array of short motifs that bind to fibronectin type I domains  . Fibronectin binding repeats are natively unfolded in the absence of fibronectin and are thought to adopt a well-defined conformation (tandem beta-zipper) upon binding  .. 
+PF03274 Foamy virus BEL 1/2 protein<br>Pfam-B_4337 (release 6.5). 
+PF03408 Foamy virus envelope protein  <br>Pfam-B_4411 (release 6.6). Expression of the envelope (Env) glycoprotein is essential for viral  particle egress.  This feature is unique to the Spumavirinae, a  subclass of the Retroviridae.. 
+PF03623 Focal adhesion targeting region<br>Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin  . The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.. 
+PF02980 Restriction endonuclease FokI, catalytic domain<br>
+PF02981 Restriction endonuclease FokI, recognition domain<br>
+PF01770 Reduced folate carrier<br>Pfam-B_1123 (release 4.2). The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy  , such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules  .. 
+PF03024 Folate receptor family<br>Pfam-B_1966 (release 6.4). This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.. 
+PF02152 Dihydroneopterin aldolase<br>This enzyme EC:4.1.2.25 catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.. 
+PF00250 FKH;<br>
+PF01226 Formate/nitrite transporter<br>
+PF02971 formiminotr; <br>Formiminotransferase domain. 
+PF02911 formyl_trans_C; <br>Formyl transferase, C-terminal domain. 
+PF00551 formyl_transf; <br>This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces formate from formyl- tetrahydrofolate. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. Inclusion of the following members is supported by PSI-blast. HOXX_BRAJA (P31907) contains a related domain of unknown function. PRTH_PORGI (P46071) contains a related domain of unknown function. Y09P_MYCTU (Q50721) contains a related domain of unknown function.. 
+PF01491 Frataxin-like domain<br>This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia.  This domain is found in a family of bacterial proteins.\.   The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.. 
+PF03197 Bacteriophage FRD2 protein<br>Pfam-B_2816 (release 6.5). 
+PF04422 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term<br>Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420.  This family contains the N termini of F420 hydrogenase and dehydrogenase beta subunits  ,  .  The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family  . This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).. 
+PF03881 Fructosamine kinase<br>This family includes eukaryotic fructosamine-3-kinase enzymes  . The family also includes bacterial members that have not been characterised but probably have a similar or identical function.. 
+PF04961 Formiminotransferase-cyclodeaminase<br>Members of this family are thought to be Formiminotransferase- cyclodeaminase enzymes EC:4.3.1.4. This domain is found in  the C-terminus of the bifunctional animal members of the family.. 
+PF01268 Formate--tetrahydrofolate ligase<br>
+PF03239 Iron permease FTR1 family<br>Pfam-B_3227 (release 6.5). 
+PF02491 FtsA;<br>SHS2 domain inserted in FTSA. FtsA is essential for bacterial cell division, and co-localises to  the septal ring with FtsZ. The SHS2 domain is inserted in to the RNAseH fold of FtsA  , and is involved in protein-protein  interaction  .. 
+PF01580 FtsK/SpoIIIE family<br>Pfam-B_458 (release 4.1). FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids  , termed the FtsK/SpoIIIE family.  This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli Swiss:P46889 and the stage III sporulation protein E SpoIIIE Swiss:P21458 which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification  . The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer  .. 
+PF04999 Cell division protein FtsL<br>In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein Pfam:PF04977  , however this interaction may be indirect  .. 
+PF03799 Cell division protein FtsQ<br>Pfam-B_1605 (release 7.0). FtsQ is one of several cell division proteins.  FtsQ interacts with other Fts proteins, reviewed in  .  The precise function of FtsQ is unknown.. 
+PF01098 Cell cycle protein<br>This entry includes the following members;    FtsW, RodA, SpoVE. 
+PF03867 Fushi tarazu (FTZ), N-terminal region<br>This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represents a category of LXXLL motif-dependent co-activators for nuclear receptors.. 
+PF02952 fucose_iso_C; <br>L-fucose isomerase, C-terminal domain. Pfam-B_9303 (Release 8.0). 
+PF02300 Fumarate reductase subunit C<br>Pfam-B_11568 (release 5.2). Fumarate reductase is a membrane-bound flavoenzyme consisting of  four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hydrophobic subunit C.. 
+PF02313 Fumarate reductase subunit D<br>Pfam-B_12414 (release 5.2). Fumarate reductase is a membrane-bound flavoenzyme consisting of  four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hydrophobic subunit D.. 
+PF03630 Fumble <br>Pfam-B_3299 (release 7.0). Fumble is required for cell division in Drosophila.  Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with  high similarity to the pantothenate kinases of A. nidulans and mouse . A role of fumble in membrane synthesis has been proposed .. 
+PF04930 FUN14 family<br>Pfam-B_8237 (release 7.5). This family of short proteins are found in eukaryotes and some archaea.  Although the function of these proteins is not known they may contain transmembrane helices.. 
+PF01475 Ferric uptake regulator family<br>Prodom_2003 (release 99.1). This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes.  This family is also known as the FUR family.. 
+PF00757 Furin-like cysteine rich region<br>
+PF04632 Fusaric acid resistance protein family<br>Pfam-B_5345 (release 7.5). This family includes a conserved region found in two proteins associated with fusaric acid resistance, Swiss:P24128 from Burkholderia cepacia  and Swiss:Q48403 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.. 
+PF00523 fusion_gly; <br>Fusion glycoprotein F0. Pfam-B_102 (release 1.0). 
+PF01621 Cell fusion glycoprotein K<br>Pfam-B_1083 (release 4.1). This protein is probably an integral membrane bound glycoprotein that is involved in viral fusion with the host cell  . . 
+PF02663 FwdE;<br>FmdE, Molybdenum formylmethanofuran dehydrogenase operon . This entry represents the FmdE protein that is encode by the molybdenum formylmethanofuran dehydrogenase operon.  FmdE does not co-purify with the molybdenum isozyme that is formed by FmdC and FmdB  .  The domain is typically found as a single copy, but is repeated in some sequence two to three times.  It is also common place to find this domain co-occurs with a zinc-beta ribbon domain, suggesting that is may bind nucleic acid and be involved in transcription regulation.. 
+PF04186 FxsA cytoplasmic membrane protein <br>This is a bacterial family of cytoplasmic membrane proteins. It includes two transmembrane regions. The molecular function of FxsA is unknown, but in Escherichia coli its over-expression has been shown to alleviate the exclusion of phage T7 in those cells with an F plasmid.. 
+PF04799 fzo_mitofusin; <br>fzo-like conserved region. Pfam-B_6217 (release 7.5). Family of putative transmembrane GTPase.  The fzo protein is a mediator of mitochondrial fusion  . This conserved region is also found in the  human mitofusin protein  .. 
+PF01125 G10 protein<br>
+PF00503 G-protein alpha subunit<br>G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring  of residues centered on the nucleotide binding site  . A Ggamma is  found fused to an inactive Galpha in the Dictyostelium protein gbqA   .. 
+PF00631 G_protein_gamma; <br>G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins  . It is also found fused to an inactive  Galpha in the Dictyostelium protein gbqA  . G-gamma likely shares a common origin with the helical N-terminal unit of G-beta  . All organisms that posses a G-beta possess a G-gamma  .. 
+PF04466 G2P; <br>Phage terminase large subunit. Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit.  This region is found on the large subunit and possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction.  This region is also found in bacterial sequences [1,2].. 
+PF04309 Glycerol-3-phosphate responsive antiterminator<br>Intracellular glycerol is usually converted to glycerol-3-phosphate in an  ATP-requiring phosphorylation reaction catalysed by glycerol kinase (GlpK) glycerol-3-phosphate activates the antiterminator GlpP  .. 
+PF00479 G6PD; <br>Glucose-6-phosphate dehydrogenase, NAD binding domain. 
+PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain<br>
+PF01468 GA module<br>Pfam-B_895 (release 4.0). The GA (protein G-related Albumin-binding) module is composed of three alpha helices  . This module is found in a range of bacterial cell surface proteins. The GA module from Swiss:Q51911 shows a strong affinity for albumin.. 
+PF02938 GAD domain<br>This domain is found in some members of the GatB and aspartyl tRNA synthetases.. 
+PF02337 Retroviral GAG p10 protein<br>Pfam-B_959 (release 5.2). This family consists of various retroviral GAG (core) polyproteins and  encompasses the p10 region producing the p10 protein upon proteolytic  cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope  glycoproteins in most mammalian retroviruses and may be involved in  virus particle assembly, transport and budding  . Some of the GAG polyproteins have alternate cleavage sites leading to  the production of alternative and longer cleavage products (e.g. p19  Swiss:P21411) the alignment of this family only covers the approximately  N-terminal (GAG) 100 amino acid region of homology to p10.. 
+PF00540 gag_p17; <br>gag gene protein p17 (matrix protein). The matrix protein forms an icosahedral shell associated with the inner membrane of the mature immunodeficiency virus.. 
+PF02228 gag_p19; <br>Major core protein p19. Pfam-B_1307 (release 5.2). p19 is a component of the inner protein layer of the viral  nucleocapsid.. 
+PF00607 gag_p24; <br>gag gene protein p24 (core nucleocapsid protein). p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus  replication both in vivo and in vitro.. 
+PF02093 Gag P30 core shell protein<br>According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly  .. 
+PF03276 Spumavirus gag protein<br>Pfam-B_1878 (release 6.5). 
+PF00337 Galactoside-binding lectin<br>This family contains galactoside binding lectins.\.   The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).. 
+PF03902 Gal4-like dimerisation domain<br>
+PF01762 Galactosyltransferase<br>Pfam-B_885 (release 4.2). This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferas e Swiss:O43825   and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase  Swiss:O54904  .  Specific galactosyltransferases transfer galactose to GlcNAc terminal  chains in the synthesis of the lacto-series oligosaccharides types 1  and 2  .. 
+PF02709 Galactosyl_T_2; Glyco_transf_2C;<br>N-terminal domain of galactosyltransferase. Pfam-B_834 (release 5.5). This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.. 
+PF01296 Galanin<br>
+PF02052 Gallidermin<br>
+PF02744 GalP_UDP_trans_C; <br>Galactose-1-phosphate uridyl transferase, C-terminal domain. SCOP reports fold duplication with N-terminal domain.  Both involved in Zn and Fe binding.. 
+PF01087 Galactose-1-phosphate uridyl transferase, N-terminal domain<br>SCOP reports fold duplication with C-terminal domain.  Both involved in Zn and Fe binding.. 
+PF00304 Gamma-thionin family<br>
+PF04410 Gar1/Naf1 RNA binding region<br>Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation  . It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex  . In humans, Gar1 is also component of telomerase in vivo  .  Naf1 is an essentail protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1  .. 
+PF01071 GARS; <br>Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain. Pfam-B_916 (release 3.0). Phosphoribosylglycinamide synthetase catalyses the second step in  the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin  carboxylase/carbamoyl phosphate synthetase (see Pfam:PF02786).. 
+PF02843 Phosphoribosylglycinamide synthetase, C domain<br>Pfam-B_916 (release 3.0). Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see Pfam:PF02787).. 
+PF02844 Phosphoribosylglycinamide synthetase, N domain<br>Pfam-B_916 (release 3.0). Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see Pfam:PF00289).. 
+PF03198 GAS1; <br>Glucanosyltransferase. Pfam-B_2209 (release 6.5). This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261  .. 
+PF02187 Growth-Arrest-Specific Protein 2 Domain<br>Alignment kindly provided by SMART. 
+PF00741 Gas vesicle protein<br>Pfam-B_545 (release 2.1). 
+PF01304 Gas vesicles protein GVPc repeated domain<br>
+PF02704 Gibberellin regulated protein<br>Pfam-B_1221 (release 5.5). This is the GASA gibberellin regulated cysteine rich protein family.  The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have some role in plant development. There are 12 cysteine residues conserved within the alignment giving the potential for these proteins to posses 6 disulphide bonds.. 
+PF00918 Gastrin/cholecystokinin family<br>Pfam-B_1542 (release 3.0). 
+PF00310 Glutamine amidotransferases class-II<br>Prosite & Pfam-B_5381 (Release 7.5) & Pfam-B_455 (release 7.6). 
+PF04572 Alpha 1,4-glycosyltransferase conserved region<br>Pfam-B_4980 (release 7.5). The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilise UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region  .  . 
+PF02263 Guanylate-binding protein, N-terminal domain<br>Pfam-B_4308 (release 5.2) & Pfam-B_9065 (release 8.0). Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.. 
+PF02841 Guanylate-binding protein, C-terminal domain<br>Pfam-B_4308 (release 5.2). Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.. 
+PF02425 Paralytic/GBP/PSP peptide<br>Pfam-B_2690 (release 5.4). This family includes insect peptides that are short (23 amino acids) and contain 1 disulphide bridge.  The family includes growth-blocking peptide (GBP) of Pseudaletia separata and the paralytic peptides from Manduca sexta, Heliothis virescens, and Spodoptera exigua   as well as plasmatocyte-spreading peptide (PSP1)  . These peptides function to halt metamorphosis from larvae to pupae.. 
+PF02526 Glycophorin-binding protein<br>Pfam-B_1047 (release 5.4). This family contains glycophorin binding proteins from P. falciparum the malarial parasite  . Glycophorin is a cell surface protein of erythrocytes. The Glycophorin binding protein contains a tandem 38 residue repeat. In Swiss:P02895 the repeat occurs 11 times.. 
+PF04551 GcpE protein<br>Pfam-B_1482 (release 7.5). In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway  .. 
+PF02155 Glucocorticoid receptor<br>
+PF04107 Glutamate-cysteine ligase family 2(GCS2)<br>Also known as gamma-glutamylcysteine synthetase and gamma-ECS (EC:6.3.2.2). This enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis. Members of this family are found in archaea, bacteria and plants. May and Leaver   discuss the possible evolutionary origins of glutamate-cysteine ligase enzymes in different organisms and suggest that it evolved independently in different eukaryotes, from an ancestral bacterial enzyme. They also state that Arabidopsis thaliana gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast and Escherichia coli homologues. In plants, there are separate cytosolic and chloroplast forms of the enzyme.. 
+PF01597 Glycine cleavage H-protein<br>Pfam-B_988 (release 4.1). This is a family of glycine cleavage H-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.. 
+PF01571 Aminomethyltransferase folate-binding domain<br>Pfam-B_933 (release 4.0). This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase. . 
+PF04295 D-galactarate dehydratase / Altronate hydrolase, C terminus<br>Family members include the C termini of D-galactarate dehydratase  (EC:4.2.1.42) which is thought to catalyse the reaction  D-galactarate = 5-keto-4-deoxy-D-glucarate + H2O,   and altronate  hydrolase (altronic acid hydratase, EC:4.2.1.7), which catalyses D-altronate = 2-keto-2-deoxygluconate + H2O  . As purified, both enzymes are catalytically inactive in the absence of  added Fe2+, Mn2+, and beta-mercaptoethanol.  Synergistic activation of altronate hydrolase activity is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre, but the function of  the single bound Fe2+ ion is unknown.  The hydratase has no Fe-S core  .. 
+PF01150 GDA1_CD39_NTPase; <br>GDA1/CD39 (nucleoside phosphatase) family. 
+PF02347 Glycine cleavage system P-protein<br>Pfam-B_840 (release 5.2). This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources.  The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC)  also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T  .  The reaction catalysed by this protein is:-  Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. 
+PF00996 GDP dissociation inhibitor<br>Pfam-B_1220 (release 3.0). 
+PF02351 GDNF/GAS1 domain<br>Pfam-B_889 (release 5.2). This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons  .  GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity  .. 
+PF02212 Dynamin GTPase effector domain<br>Alignment kindly provided by SMART. 
+PF04807 Geminivirus AC4/5 conserved region<br>Pfam-B_3520 (release 7.6). 
+PF00799 Geminivirus_AL1;<br>Geminivirus Rep catalytic domain. Pfam-B_286 (release 2.1). The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome  . For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer  .. 
+PF01440 Geminivirus AL2 protein<br>Prodom_1117 (release 99.1). Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL2 gene product transactivates expression of TGMV coat protein gene  , and BR1 movement protein.. 
+PF01407 Geminivirus AL3 protein<br>Pfam-B_1874 (release 3.0). Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL3 protein comprises approximately 0.05% of the cellular proteins and is present in the soluble and organelle fractions  . AL3 may form oligomers  . Immunoprecipitation of AL3 in a baculovirus expression system extracts expressing both AL1 Pfam:PF00799 and AL3 showed that the two proteins also complex with each other  . The AL3 protein is involved in viral replication.. 
+PF00845 Geminivirus BL1 movement protein<br>Pfam-B_1535 (release 2.1). Geminiviruses encode two movement proteins that are essential for systemic infection of their host but dispensable for replication and encapsidation.. 
+PF01492 Geminivirus C4 protein<br>Pfam-B_453 (release 4.0). This family consists of the N terminal region of geminivirus C4 or AC4 proteins.  In Tomato yellow leaf curl geminivirus (TYLCV) the C4 protein is necessary for efficient spreading of the virus in tomato plants  .. 
+PF00844 Geminivirus coat protein/nuclear export factor BR1 family<br>Pfam-B_1430 (release 2.1). It has been shown that the 104 N-terminal amino acids of the maize streak virus coat protein bind DNA non- specifically  . This family also includes various geminivirus movement proteins that are nuclear export factors or shuttles. One member BR1 facilitates the export of both ds and ss DNA form the nucleus  .. 
+PF01708 Geminivirus putative movement protein <br>Pfam-B_1771 (release 4.1). This family consists of putative movement proteins from Maize streak and wheat dwarf virus.. 
+PF01524 Geminivirus V1 protein<br>Pfam-B_893 (release 4.0). Disruption of the V1 gene in Tomato yellow leaf curl virus (TYLCV) stopped its ability to systemically infect tomato plants, suggesting that the V1 gene product is required for successful infection of the host  .. 
+PF02053 Gene 66 (IR5) protein<br>
+PF03323 Bacillus/Clostridium GerA spore germination protein<br>Pfam-B_3821 (release 6.5). 
+PF00196 Bacterial regulatory proteins, luxR family<br>
+PF01353 Green fluorescent protein<br>
+PF05165 GGDN family<br>I have named this protein family of unknown function GGDN after the most conserved motif. The proteins are 200-270 amino acids in length.. 
+PF01134 Glucose inhibited division protein A<br>Prosite & Pfam-B_4007 (Release 8.0). 
+PF02527 rRNA small subunit methyltransferase G<br>Pfam-B_1265 (release 5.4). This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision  . GidB has been shown to be a methyltransferase G specific to the rRNA small subunit [2, 3]. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA  .. 
+PF03227 Gamma interferon inducible lysosomal thiol reductase (GILT)<br>Pfam-B_1477 (release 6.5). This family includes the two characterised human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: Swiss:P13284   and Swiss:Q9UL08  . It also contains several other eukaryotic putative proteins with similarity to GILT  . The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.. 
+PF03359 Guanylate-kinase-associated protein (GKAP) protein<br>Pfam-B_1892 (release 6.6). 
+PF03275 UDP-galactopyranose mutase<br>Pfam-B_4203 (release 6.5). 
+PF02812 E_L_F_V_dh; GLFV_dehydrog_N; <br>Glu/Leu/Phe/Val dehydrogenase, dimerisation domain. 
+PF00120 gln-synt; <br>Glutamine synthetase, catalytic domain. 
+PF03951 gln-synt_N; <br>Glutamine synthetase, beta-Grasp domain. 
+PF03710 Glutamate-ammonia ligase adenylyltransferase<br>Conserved repeated domain found in GlnE proteins. These proteins  adenylate and deadenylate glutamine synthases: ATP + {L-Glutamate:ammonia ligase (ADP-forming)} = Diphosphate + Adenylyl-{L-Glutamate:Ammonia ligase  (ADP-forming)}. The family is related to the  Pfam:PF01909 domain.. 
+PF03616 Sodium/glutamate symporter<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01744 GLTT repeat (6 copies)<br>Pfam-B_681 (release 4.2). This short repeat of unknown function is found in multiple copies in several C. elegans proteins. The repeat is five residues long and consists of XGLTT where X can be any amino acid.. 
+PF02686 Glu-tRNAGln amidotransferase C subunit<br>This is a family of Glu-tRNAGln amidotransferase C subunits. The Glu-tRNA Gln amidotransferase enzyme itself is an important translational fidelity mechanism replacing incorrectly charged Glu-tRNAGln with the correct Gln-tRANGln via transmidation of the misacylated Glu-tRNAGln  .  This activity supplements the lack  of glutaminyl-tRNA synthetase activity in gram-positive eubacterteria, cyanobacteria, Archaea, and organelles  .. 
+PF05096 Glutamine cyclotransferase<br>This family of enzymes EC:2.3.2.5 catalyse the cyclization of free L-glutamine and N-terminal glutaminyl residues in proteins to pyroglutamate (5-oxoproline) and pyroglutamyl residues respectively  . This family includes plant and bacterial enzymes and seems unrelated to the mammalian enzymes.. 
+PF04262 glu_cys_ligase; <br>Glutamate-cysteine ligase . TIGRFAMs (release 2.0);. Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that carry out the first step of the glutathione biosynthesis pathway.. 
+PF01645 Conserved region in glutamate synthase<br>Pfam-B_719 (release 4.1). This family represents a region of the glutamate synthase protein.  This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organisms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster.. 
+PF02364 1,3-beta-glucan synthase component <br>Pfam-B_686 (release 5.2). This family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2 and Gls3 from yeast. 1,3-beta-glucan synthase EC:2.4.1.34 also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall  . The reaction catalysed is:- UDP-glucose + {(1,3)-beta-D-glucosyl}(N) <=> UDP + {(1,3)-beta-D-glucosyl}(N+1).. 
+PF02685 Glucokinase<br>This is a family of glucokinases or glucose kinases EC:2.7.1.2. These enzymes phosphorylate glucose using ATP as a donor to give glucose-6-phosphate and ADP.. 
+PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase<br>
+PF00462 glutaredoxin; <br>Prosite & Pfam-B_3081 (Release 8.0). 
+PF04399 Glutaredoxin 2, C terminal domain<br>Glutaredoxins are a multifunctional family of glutathione-dependent disulphide oxidoreductases.  Unlike other glutaredoxins, glutaredoxin 2 (Grx2) cannot reduce ribonucleotide reductase.  Grx2 has significantly higher catalytic activity in the reduction of mixed disulphides with glutathione (GSH) compared with other glutaredoxins. The active site residues (Cys9-Pro10-Tyr11-Cys12, in Escherichia coli Grx2, Swiss:P39811), which are found at the interface between the N- and C-terminal domains are identical to other glutaredoxins, but there is no other similarity between glutaredoxin 2 and other glutaredoxins. Grx2 is structurally similar to glutathione-S-transferases (GST), but there is no obvious sequence similarity. The inter-domain contacts are mainly hydrophobic, suggesting that the two domains are unlikely to be stable on their own.  Both domains are needed for correct folding and activity of Grx2. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with GSH in cellular redox regulation including the response to oxidative stress.. 
+PF03157 High molecular weight glutenin subunit<br>Pfam-B_2180 (release 6.5). Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues.  High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterised by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm [see 1, fig.2].. 
+PF00745 GlutR; <br>Glutamyl-tRNAGlu reductase, dimerisation domain. Pfam-B_544 (release 2.1). 
+PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain<br>
+PF02595 DUF168; <br>Glycerate kinase family. This is family of Glycerate kinases.. 
+PF01228 Glycine radical<br>
+PF00232 glycosyl_hydro1; <br>Glycosyl hydrolase family 1. 
+PF00331 glycosyl_hydro3; <br>Glycosyl hydrolase family 10. 
+PF00457 glycosyl_hydro6; <br>Glycosyl hydrolases family 11. 
+PF01109 Granulocyte-macrophage colony-stimulating factor<br>
+PF01670 Glycosyl hydrolase family 12<br>Pfam-B_1736 (release 4.1). 
+PF01373 Glycosyl_hydr22; <br>Glycosyl hydrolase family 14. This family are beta amylases.. 
+PF00723 glycosyl_hydr10;<br>Glycosyl hydrolases family 15. Pfam-B_771 (release 2.1). In higher organisms this family is represented by phosphorylase kinase subunits.. 
+PF00332 glycosyl_hydro4; <br>Glycosyl hydrolases family 17. 
+PF00182 chitinase_1; <br>
+PF00703 glycosyl_hydro7;<br>Glycosyl hydrolases family 2. Pfam-B_572 (release 2.1). This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.. 
+PF00728 glycosyl_hydr11; <br>Glycosyl hydrolase family 20, catalytic domain. Pfam-B_877 (release 2.1). This domain has a TIM barrel fold.. 
+PF02838 glycosyl_hydr11; <br>Glycosyl hydrolase family 20, domain 2. Pfam-B_877 (release 2.1). This domain has a zincin-like fold.. 
+PF01183 Glycosyl_hydr18;<br>Glycosyl hydrolases family 25. 
+PF02156 Glycosyl hydrolase family 26<br>
+PF00295 PG; <br>Glycosyl hydrolases family 28. Glycosyl hydrolase family 28 includes polygalacturonase EC:3.2.1.15 as well as rhamnogalacturonase A(RGase A), EC:3.2.1.-.  These enzymes is important in cell wall metabolism.. 
+PF02836 glycosyl_hydro7; <br>Glycosyl hydrolases family 2, TIM barrel domain. Pfam-B_572 (release 2.1). This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.. 
+PF02837 glycosyl_hydro7; <br>Glycosyl hydrolases family 2, sugar binding domain. Pfam-B_572 (release 2.1). This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold.. 
+PF00933 glycosyl_hydr14;<br>Glycosyl hydrolase family 3 N terminal domain. Pfam-B_1151 (release 3.0). 
+PF00251 glycosyl_hydro2; Glyco_hydro_32; <br>Glycosyl hydrolases family 32 N-terminal domain. This domain corresponds to the N-terminal domain of glycosyl hydrolase family 32 which forms a five bladed beta propeller structure  .. 
+PF01301 Glycosyl_hydr17; <br>Glycosyl hydrolases family 35. 
+PF01074 Glycosyl_hydr16;<br>Glycosyl hydrolases family 38 N-terminal domain. Pfam-B_731 (release 3.0). Glycosyl hydrolases are key enzymes of carbohydrate metabolism.. 
+PF01229 Glycosyl_hydr19;<br>Glycosyl hydrolases family 39. 
+PF01915 glycosyl_hydr14; <br>Glycosyl hydrolase family 3 C-terminal domain. Pfam-B_1151 (release 3.0). This domain is involved in catalysis and may be involved in binding beta-glucan  . This domain is found associated with Pfam:PF00933.. 
+PF02056 Family 4 glycosyl hydrolase<br>
+PF02449 Beta-galactosidase<br>Pfam-B_2131 (release 5.4). This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyses the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.. 
+PF04616 Glycosyl hydrolases family 43<br>Pfam-B_5336 (release 7.5). The glycosyl hydrolase family 43 contains members that are arabinanase.  Rabinanases hydrolyses the alpha-1,5-linked  L-arabinofuranoside backbone of plant cell wall arabinans.  The structure of arabinanase Arb43A from Cellvibrio japonicus reveals a five-bladed beta-propeller fold. A long V-shaped  groove, partially enclosed at one end, forms a single extended  substrate-binding surface across the face of the propeller  .. 
+PF02015 Glycosyl hydrolase family 45<br>
+PF01374 Glycosyl_hydr23; <br>Glycosyl hydrolase family 46. This family are chitosanase enzymes.. 
+PF02011 Glycosyl hydrolase family 48<br>Members of this family are endoglucanase EC:3.2.1.4 and exoglucanase EC:3.2.1.91 enzymes that cleave cellulose or related substrate.. 
+PF03718 Glycosyl hydrolase family 49<br>Family of dextranase (EC 3.2.1.11) and isopullulanase (EC 3.2.1.57). Dextranase hydrolyses alpha-1,6-glycosidic bonds in dextran polymers.. 
+PF03512 Glycosyl hydrolase family 52<br>
+PF01630 Hyaluronidase<br>Pfam-B_1150 (release 4.1). 
+PF03065 Glycosyl hydrolase family 57<br>Pfam-B_2506 (release 6.4). This family includes alpha-amylase (EC:3.2.1.1), 4--glucanotransferase (EC:2.4.1.-) and amylopullulanase enzymes.. 
+PF02057 Glycosyl hydrolase family 59<br>
+PF01341 Glycosyl_hydr21; <br>Glycosyl hydrolases family 6. 
+PF03443 Glycosyl hydrolase family 61<br>Although weak endoglucanase activity has been demonstrated in several members of this family [1-3], they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases  .. 
+PF03664 Glycosyl hydrolase family 62 <br>Family of alpha -L-arabinofuranosidase (EC 3.2.1.55).  This enzyme hydrolysed aryl alpha-L-arabinofuranosides and  cleaves arabinosyl side chains from arabinoxylan and arabinan. . 
+PF03633 Glyco_hydro_65c; <br>Glycosyl hydrolase family 65, C-terminal domain . Pfam-B_3470 (release 7.0). This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP)  is a dimeric enzyme that catalyses the conversion of maltose and  inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  The C-terminal domain forms a two layered jelly roll motif.  This domain is situated at the base of the catalytic domain, however its function remains unknown  .. 
+PF03632 Glycosyl hydrolase family 65 central catalytic domain<br>Pfam-B_3470 (release 7.0). This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. The central domain is the catalytic domain, which binds a phosphate ion that is proximal the the highly conserved Glu.  The arrangement of the phosphate and the glutamate is thought to cause nucleophilic attack on the anomeric carbon atom  .  The catalytic domain also forms the majority of the dimerisation interface.. 
+PF03636 Glyco_hydro_65n; <br>Glycosyl hydrolase family 65, N-terminal domain . Pfam-B_3470 (release 7.0). This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP)  is a dimeric enzyme that catalyses the conversion of maltose and  inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  This domain is believed to be essential for catalytic activity   although its precise function remains unknown.. 
+PF02435 Levansucrase/Invertase<br>Pfam-B_2011 (release 5.4). This Pfam family consists of the glycosyl hydrolase 68 family, including several bacterial levansucrase enzymes, and invertase from zymomonas.. 
+PF00840 glycosyl_hydr13; <br>Glycosyl hydrolase family 7. Pfam-B_1478 (release 2.1). 
+PF02324 Gluco_S_transf; <br>Glycosyl hydrolase family 70. Pfam-B_965 (release 5.2). Members of this family belong to glycosyl hydrolase family 70   Glucosyltransferases or sucrose 6-glycosyl transferases (GTF-S) catalyse the transfer of D-glucopyramnosyl units from sucrose  onto acceptor molecules  , EC:2.4.1.5.  This family roughly corresponds to the N-terminal catalytic domain of the enzyme. Members of this family also contain the Putative cell wall binding domain Pfam:PF01473, which corresponds with the C-terminal glucan-binding domain.. 
+PF03659 Glycosyl hydrolase family 71 <br>Family of alpha-1,3-glucanases. . 
+PF03662 Glycosyl hydrolase family 79, N-terminal domain <br>Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment.  Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form.  Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity  .. 
+PF01270 Glycosyl_hydr20; <br>Glycosyl hydrolases family 8. 
+PF03639 Glycosyl hydrolase family 81 <br>Family of eukaryotic beta-1,3-glucanases. Within the Aspergillus fumigatus protein Swiss:Q9UVV0 two perfectly conserved Glu residues (E550 or E554) have been proposed as putative nucleophiles of the active site of the Engl1 endoglucanase, while the proton donor would be D475. The endo-beta-1,3-glucanase activity is essential for efficient spore release  .. 
+PF00759 glycosyl_hydr12; <br>Glycosyl hydrolase family 9. Pfam-B_843 (release 2.1). 
+PF03808 Glycosyl transferase WecB/TagA/CpsF family<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01531 Glycosyl transferase family 11<br>Pfam-B_935 (release 4.0). This family contains several fucosyl transferase enzymes.. 
+PF01793 Glycolipid 2-alpha-mannosyltransferase<br>Pfam-B_1324 (release 4.2). This is a family of alpha-1,2 mannosyl-transferases involved in N-linked and O-linked glycosylation of proteins.  Some of the enzymes in this family have been shown to be involved in O- and N-linked glycan modifications in the Golgi  .. 
+PF03076 Equine arteritis virus GP3<br>Pfam-B_687 (release 6.4). This protein is encoded by ORF3 of equine arteritis virus. The function is unknown.. 
+PF04724 Glyco_tranf_17; <br>Glycosyltransferase family 17. Pfam-B_5914 (release 7.5). This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression [1,2].. 
+PF03033 Glycosyltransferase family 28 N-terminal domain<br>Pfam-B_1105 (release 6.4) & Pfam-B_2764 (release 7.5). The glycosyltransferase family 28 includes  monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.. 
+PF04666 GnT_IV_N; Glyco_transf_55; <br>N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region. Pfam-B_4541 (release 7.5). The complex-type of oligosaccharides are synthesised through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide).  In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein  .. 
+PF03414 Glycosyltransferase family 6<br>Pfam-B_4383 (release 6.6). 
+PF01075 Heptosyltranf;<br>Glycosyltransferase family 9 (heptosyltransferase). Pfam-B_839 (release 3.0). Members of this family belong to glycosyltransferase family 9  .  Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.. 
+PF00274 glycolytic_enzy; <br>Fructose-bisphosphate aldolase class-I. 
+PF01102 Glycophorin A<br>
+PF00606 Herpesvirus Glycoprotein B<br>This family of proteins contains a transmembrane region.. 
+PF00802 Pneumovirus attachment glycoprotein G<br>Pfam-B_1049 (release 2.1). This family includes attachment proteins from respiratory synctial virus.  Glycoprotein G has not been shown to have any neuraminidase or hemagglutinin activity (Swiss-Prot). The amino terminus is thought to be cytoplasmic, and the carboxyl terminus extracellular.  The extracellular region contains four completely conserved cysteine residues.. 
+PF02885 glycosyl_transf_3; <br>Glycosyl transferase family, helical bundle domain. MRC-LMB Genome group. This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase.  All these proteins can transfer a phosphorylated ribose substrate.. 
+PF00534 glycosyl_transf_1; <br>Glycosyl transferases group 1. MRC-LMB Genome group. Mutations in this domain of Swiss:P37287 lead to disease  (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety  of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP,  GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.. 
+PF00591 glycosyl_transf_3; <br>Glycosyl transferase family, a/b domain. MRC-LMB Genome group. This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase.  All these proteins can transfer a phosphorylated ribose substrate.. 
+PF04413 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)<br>Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides.  Members of the family transfer UDP, ADP, GDP or CMP linked sugars.  The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (Pfam:PF00534).  The eukaryotic  glycogen synthases may be distant members of this bacterial  family  .. 
+PF01153 Glypican<br>
+PF05199 GMC oxidoreductase<br>Pfam-B_891 (release 2.1). This domain found associated with Pfam:PF00732.. 
+PF00732 GMC_oxred; <br>Pfam-B_891 (release 2.1). This family of proteins bind FAD as a cofactor.. 
+PF00446 Gonadotropin-releasing hormone<br>
+PF03071 GNT-I family<br>Pfam-B_2207 (release 6.4). Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, GLCNAC-T I) EC:2.4.1.101 transfers N-acetyl-D-glucosamine from  UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localised to the Golgi  apparatus, and is probably distributed in all tissues. The catalytic domain is located at the C-terminus  .. 
+PF02447 GntP family permease<br>Pfam-B_1928 (release 5.4). This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU Swiss:P46858 a low affinity transporter   and GntT Swiss:P39835 a high affinity transporter  .. 
+PF00392 gntR; <br>Bacterial regulatory proteins, gntR family. Prosite & Pfam-B_6405 (Release 8.0). This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR [1-2]  . Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships  . The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor  .. 
+PF02188 GoLoco motif<br>Alignment kindly provided by SMART. 
+PF04178 Got1/Sft2-like family <br>Pfam-B_7371 (release 7.3) & Pfam-B_8991 (release 14.0). Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae.  Got1 is thought to facilitate Sed5-dependent fusion events  .  This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein (Swiss:P38166)  . This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments  .. 
+PF00516 Envelope glycoprotein GP120<br>Pfam-B_44 (release 1.0). The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.. 
+PF03010 GP4<br>Pfam-B_1094 (release 6.4). GP4 is a minor membrane-associated glycoproteins. This family contains envelope protein GP4 from equine arteritis virus.. 
+PF00517 Retroviral envelope protein<br>Pfam-B_44 (release 1.0). This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).. 
+PF02925 Bacteriophage scaffolding protein D<br>
+PF00044 gpdh; <br>Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain. Eddy SR, Griffiths-Jones SR. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold.. 
+PF02800 gpdh_C; <br>Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. Eddy SR, Griffiths-Jones SR. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.. 
+PF05024 N-acetylglucosaminyl transferase component (Gpi1)<br>Pfam-B_4796 (release 7.6). Glycosylphosphatidylinositol (GPI) represents an important anchoring  molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to  phosphatidylinositol (PI). This chemically simple step is genetically  complex because three or four genes are required in both yeast  (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively  .. 
+PF04113 Gpi16 subunit, GPI transamidase component<br>Pfam-B_7012 (release 7.3);. GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex.  Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase  that adds glycosylphosphatidylinositols (GPIs) to newly  synthesised proteins.  Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small  C-terminal, cytosolic extension with an ER retrieval motif  .. 
+PF02831 gpW<br>gpW is a 68 residue protein known to be present in  phage particles. Extracts of phage-infected cells lacking gpW contain DNA-filled heads, and active tails, but no infectious virions. gpW is required for the addition of gpFII to the head, which is, in turn, required for the attachment of tails. Since gpFII and tails are known to be attached at the connector, gpW is also likely to assemble at this site. The addition of gpW to filled heads increases the DNase resistance of the packaged DNA, suggesting that gpW either forms a plug at the connector to prevent ejection of the DNA, or binds directly to the DNA. The large number of positively charged residues in gpW (its calculated pI is 10.8) is consistent with a role in DNA interaction  .. 
+PF04965 Gene 25-like lysozyme<br>This family includes the phage protein Gene 25 from T4 which is a structural component of the outer wedge of the baseplate that has acidic lysozyme activity  . The family also includes relatives from bacteria that are also presumably lysozymes.. 
+PF05084 Granule antigen protein (GRA6)<br>Pfam-B_6204 (release 7.7). This family contains the granule antigen protein GRA6 which is found in the parasitic protozoa Toxoplasma gondii and Neospora caninum. GRA6 protein plays an important role in the antigenicity and pathogenicity in these organisms  .. 
+PF00267 Gram-ve_porins; <br>
+PF00746 Gram positive anchor<br>Pfam-B_457 (release 2.1). 
+PF01271 Granin (chromogranin or secretogranin)<br>
+PF00396 granulin; <br>
+PF04495 GRASP55/65 PDZ-like domain <br>Pfam-B_3985 (release 7.5). GRASP55 (Golgi re-assembly stacking protein of 55 kDa) and GRASP65 (a 65 kDa) protein are highly homologous. GRASP55 is a component of the Golgi stacking machinery. GRASP65, an N-ethylmaleimide- sensitive membrane protein required for the stacking of Golgi cisternae in a cell-free system  .  This region appears to be related to the PDZ domain.. 
+PF04723 Glycine reductase complex selenoprotein A<br>Found in clostridia, this protein contains one active site selenocysteine and catalyses the reductive deamination of glycine, which is coupled to the esterification of orthophosphate resulting in the formation of ATP  . A member of this family may also exist in Treponema denticola  .. 
+PF01272 Transcription elongation factor, GreA/GreB, C-term<br>This domain has an FKBP-like fold.. 
+PF03449 Transcription elongation factor, N-terminal<br>This domain adopts a long alpha-hairpin structure.. 
+PF01184 GPR1/FUN34/yaaH family<br>The Ady2 protein in (Swiss:P25613) is required for acetate in Saccharomyces cerevisiae, and is probably an acetate transporter. A homologue in Yarrowia lipolytica (GPR1) has a role in acetic acid sensitivity.. 
+PF01025 GrpE<br>Pfam-B_817 (release 3.0). 
+PF02955 Prokaryotic glutathione synthetase, ATP-grasp domain<br>
+PF02951 GTS_N; <br>Prokaryotic glutathione synthetase, N-terminal domain. 
+PF03917 Eukaryotic glutathione synthase, ATP binding domain<br>Pfam-B_2922 (release 6.5). 
+PF03199 Eukaryotic glutathione synthase<br>Pfam-B_2922 (release 6.5). 
+PF00255 Glutathione peroxidase<br>
+PF03738 Glutathionylspermidine synthase preATP-grasp<br>This region contains the Glutathionylspermidine synthase enzymatic activity EC:6.3.1.8. This is the C-terminal region in bienzymes such as Swiss:P43675. Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design  . This region, the pre-ATP grasp region, probably carries the substrate-binding site  .. 
+PF00437 GSPII_E;<br>Type II/IV secretion system protein. Prosite & Pfam-B_2215 (Release 8.0). This family contains both type II and type IV Swiss:P54907 pathway secretion proteins from bacteria. Swiss:P07169 VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection  . . 
+PF05157 GSPII_E_N;<br>Type II secretion system (T2SS), protein E, N-terminal domain. This domain is found at the N-terminus of members of the Type II secretion system protein E. Proteins in this subfamily are typically involved in Type 4 pilus biogenesis (eg Swiss:Q9X4G8), though some are involved in other processes; for instance aggregation in Myxococcus xanthus (Swiss:Q9RF11)  . The structure of this domain is now known [2,3].. 
+PF00482 GSPII_F;<br>Type II secretion system (T2SS), protein F. The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella  . This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).. 
+PF00263 Bac_GSPproteins; GSPII_III; Secretin; Secretin_C; <br>Bacterial type II and III secretion system protein. 
+PF01203 T2SP_N; GSPII_N;<br>Type II secretion system (T2SS), protein N. Members of the T2SN family are involved in the Type II protein secretion system. The precise function of these proteins is unknown.. 
+PF03958 NolW-like; GSPII_III_N; <br>Bacterial type II/III secretion system short domain. This is a short, often repeated, domain found in bacterial type II/III secretory system proteins.\.    All previous NolW-like domains fall into this family.. 
+PF02501 GSPII_IJ;<br>Type II secretion system (T2SS), protein I. Pfam-B_2607 (release 5.4). The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. As members of the T2SJ family, members of the T2SI family are pseudopilins containing prepilin signal sequences  .. 
+PF03934 GspK;<br>Type II secretion system (T2SS), protein K. Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX  and XcpX.. 
+PF05134 GspL;<br>Type II secretion system (T2SS), protein L. Pfam-B_6494 (release 7.7). This family consists of Type II secretion system protein L sequences from several Gram-negative (diderm) bacteria. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. T2SL is predicted to contain a large cytoplasmic domain represented by this family and has been shown to interact with the autophosphorylating cytoplasmic membrane protein T2SE. It is thought that the tri-molecular complex of T2SL, T2SE (Pfam:PF00437) and T2SM (Pfam:PF04612) might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation  .. 
+PF04612 GspM;<br>Type II secretion system (T2SS), protein M. Pfam-B_5302 (release 7.5). This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers  .. 
+PF00043 gluts; GST;<br>Glutathione S-transferase, C-terminal domain. Eddy SR, Griffiths-Jones SR. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants.  Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity.\. The glutathione molecule binds in a cleft between N and  C-terminal domains. The catalytically important residues are proposed  to reside in the N-terminal domain  . In plants, GSTs are encoded by  a large gene family (48 GST genes in Arabidopsis) and can be divided  into the phi, tau, theta, zeta, and lambda classes  .. 
+PF02798 gluts; <br>Glutathione S-transferase, N-terminal domain. Eddy SR, Griffiths-Jones SR. Function: conjugation of reduced glutathione to a variety of  targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST  activity; similarity not previously recognised. * HSP26 family of stress-related proteins. including auxin-regulated  proteins in plants and stringent starvation proteins in E. coli.  Not known to have GST activity. Similarity not previously recognised. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain  .. 
+PF00735 GTP_CDC; <br>Pfam-B_440 (release 2.1). Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin.  Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerise to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis  .. 
+PF00925 GTP cyclohydrolase II<br>Pfam-B_1147 (release 3.0). GTP cyclohydrolase II catalyses the first committed step in the biosynthesis of riboflavin.. 
+PF01227 GTP_cyclohydro_I; <br>GTP cyclohydrolase I. This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.. 
+PF04670 Gtr1/RagA G protein conserved region<br>Pfam-B_4577 (release 7.5). GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1.\.      Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family.       The RagA/B proteins are the human homologues of Gtr1.     Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].. 
+PF04138 GtrA-like protein<br>Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans.  They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans.  It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation.  Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane  . Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyses the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b) . This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains.  Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose  .. 
+PF00211 guanylate_cyc; <br>Adenylate and Guanylate cyclase catalytic domain. 
+PF00625 Guanylate kinase<br>
+PF02058 Guanylin precursor<br>
+PF05120 Gas vesicle protein G <br>These proteins are involved in the formation of gas vesicles ( ).. 
+PF05121 Gas vesicle protein K  <br>These proteins are involved in the formation of gas vesicles ( ).. 
+PF02213 GYF domain<br>Alignment kindly provided by SMART. The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.. 
+PF02895 Signal transducing histidine kinase, homodimeric domain<br>This helical bundle domain is the homodimer interface  of the signal transducing histidine kinase family.. 
+PF03030 Inorganic H+ pyrophosphatase<br>Pfam-B_1050 (release 6.4). The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists  .. 
+PF01725 Ham1 family<br>Pfam-B_2030 (release 4.1). This family consists of the HAM1 protein Swiss:P47119 and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae Swiss:P47119  . The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions  .. 
+PF04388 Hamartin protein<br>This family includes the hamartin protein which is thought to function as a tumour suppressor.  The hamartin protein interacts with the tuberin protein Pfam:PF03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin Pfam:PF03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking  .. 
+PF01567 Hantavirus glycoprotein G1<br>Pfam-B_399 (release 4.0). The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA. . 
+PF01561 Hantavirus glycoprotein G2<br>Pfam-B_401 (release 4.0). The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA. . 
+PF00846 Hantavirus nucleocapsid protein<br>Pfam-B_310 (release 3.0). 
+PF03866 Hydrophobic abundant protein (HAP)        <br>Expression of HAP is thought to be developmentally regulated and possibly involved in spherule cell wall formation  .   . 
+PF01543 Hepatitis C virus capsid protein<br>
+PF01542 Hepatitis C virus core protein<br>The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases  . The N terminus of the core protein is involved in transcriptional repression  .. 
+PF01539 Hepatitis C virus envelope glycoprotein E1<br>
+PF01560 Hepatitis C virus non-structural protein E2/NS1<br>The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein  .. 
+PF01538 Hepatitis C virus non-structural protein NS2<br>The viral genome is translated into a single polyprotein of about 3000 amino acids. Generation of the mature non-structural proteins relies on the activity of viral proteases.  Cleavage at the NS2/NS3 junction is accomplished by a metal-dependent autoprotease encoded within NS2 and the N-terminus of NS3 [1,2].. 
+PF02907 HCV_NS3; <br>Hepatitis C virus NS3 protease. Griffiths-Jones SR, Knutson S. Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold.  The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3.  The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins.  The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A.. 
+PF01006 Hepatitis C virus non-structural protein NS4a<br>Pfam-B_315 (release 3.0). NS4a forms an integral part of the NS3 serine protease, as  it is required in a number of cases as a cofactor of cleavage [1,3]. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex  .. 
+PF01001 Hepatitis C virus non-structural protein NS4b<br>Pfam-B_315 (release 3.0). No precise function has been assigned to NS4b.  However, it is known that NS4b interacts with NS4a and NS3 to form a large replicase complex to direct the viral RNA replication  .. 
+PF01506 Hepatitis C virus non-structural 5a protein membrane anchor<br>The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2].  The N-terminal region of the NS5a protein has been used in the construction of the alignment for this family.  The C-terminal region has not been included because it is too heterogeneous.. 
+PF04618 HD-ZIP protein N terminus<br>This family consists of the N termini of plant homeobox-leucine zipper proteins. Its function is unknown.. 
+PF02329 Histidine carboxylase PI chain<br>Pfam-B_19599 (release 5.2). Histidine carboxylase catalyses the formation of histamine from histidine. Cleavage of the proenzyme PI chain yields two subunits,  alpha and beta, which arrange as a hexamer (alpha beta)6. . 
+PF02924 Bacteriophage lambda head decoration protein D<br>
+PF01517 Hepatitis delta virus delta antigen<br>Pfam-B_808 (release 4.0). The hepatitis delta virus (HDV) encodes a single protein, the hepatitis delta antigen (HDAg).  The central region of this protein has been shown to bind RNA  .  Several interactions are also mediated by a coiled-coil region at the N terminus of the protein  .. 
+PF02985 HEAT repeat<br>The HEAT repeat family is related to armadillo/beta-catenin-like  repeats (see Pfam:PF00514).. 
+PF03130 PBS lyase HEAT-like repeat<br>Pfam-B_172 (release 6.5). This family contains a short bi-helical repeat that is related to Pfam:PF02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase Swiss:P31967 Swiss:P31968, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin  . Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six)  . All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond.  Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerised to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerisation reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase  . Another member of this family is the NblB protein Swiss:Q9Z3G5, whose similarity to the phycobiliprotein lyases was previously noted  .  This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif  .. 
+PF00632 HECT-domain (ubiquitin-transferase)<br>The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.. 
+PF03451 HELP motif<br>The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family.  The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain  .  In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation  .  The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.. 
+PF03996 Hemagglutinin esterase<br>Pfam-B_505 (release 5.5). 
+PF02710 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein<br>Pfam-B_505 (release 5.5). 
+PF00509 Haemagglutinin<br>Pfam-B_26 (release 1.0). Hemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalises the virus by endocytosis.  The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.. 
+PF01126 Heme_oxygnease;<br>
+PF00372 hemocyanin; <br>Hemocyanin, copper containing domain. This family includes arthropod hemocyanins and insect larval storage proteins.. 
+PF03723 hemocyanin_C; <br>Hemocyanin, ig-like domain. This family includes arthropod hemocyanins and insect larval storage proteins.. 
+PF03722 hemocyanin_N; <br>Hemocyanin, all-alpha domain. This family includes arthropod hemocyanins and insect larval storage proteins.. 
+PF00045 hemopexin; <br>Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).. 
+PF05171 Haemin-degrading HemS.ChuX domain<br>The Yersinia enterocolitica O:8 periplasmic binding-protein- dependent transport system consisted of four proteins: the periplasmic haemin-binding protein HemT, the haemin permease protein HemU, the ATP-binding hydrophilic protein HemV and the haemin-degrading protein HemS (this family). The structure for HemS has been solved and consists of a tandem repeat of this domain.. 
+PF00906 Hepatitis core antigen<br>Pfam-B_8 (release 3.0). The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA  . There is some experimental evidence to support this  .. 
+PF01771 Herpesvirus alkaline exonuclease<br>Pfam-B_822 (release 4.2). This family includes various alkaline exonucleases from members of the herpesviridae. Alkaline exonuclease  appears to have an important role in the replication of herpes simplex virus  .. 
+PF04793 BRRF1-like protein<br>Pfam-B_6247 (release 7.5). Family of herpesvirus proteins including Epstein-barr virus protein BBRF1.   . 
+PF05109 Herpes virus major outer envelope glycoprotein (BLLF1)<br>Pfam-B_6348 (release 7.7). This family consists of the BLLF1 viral late glycoprotein, also termed  gp350/220. It is the most abundantly expressed glycoprotein in the viral  envelope of the Herpesviruses and is the major antigen responsible for  stimulating the production of neutralising antibodies in vivo  .. 
+PF04633 Herpesvirus BMRF2 protein<br>Pfam-B_5353 (release 7.5). 
+PF04682 Herpesvirus BTRF1 protein conserved region<br>Pfam-B_4518 (release 7.5). Herpesvirus protein.. 
+PF04929 Herpes DNA replication accessory factor <br>Pfam-B_5837 (release 7.6). Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate.  The Epstein-Barr virus (EBV) BMRF1 protein is an essential component of the viral DNA polymerase and is absolutely required for lytic virus replication  . BMRF1 is also a transactivator  .  This family is predicted to have a UL42 like structure  .. 
+PF01673 Herpesvirus putative major envelope glycoprotein<br>Pfam-B_1084 (release 4.1). This family consists of probable major envelope glycoproteins from members of the herpesviridae including herpes simplex  virus, human cytomegalovirus and varicella-zoster virus. Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication. . 
+PF02480 Alphaherpesvirus glycoprotein E<br>Pfam-B_849 (release 5.4). Glycoprotein E (gE) of Alphaherpesvirus forms a complex with  glycoprotein I (gI) (Pfam:PF01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation  .. 
+PF01688 Alphaherpesvirus glycoprotein I<br>Pfam-B_1222 (release 4.1). This family consists of glycoprotein I form various members of the  alphaherpesvirinae these include herpesvirus, varicella-zoster virus and pseudorabies virus. Glycoprotein I (gI) is important during natural  infection, mutants lacking gI produce smaller lesions at the site of infection and show reduced neuronal spread  . gI forms a heterodimeric complex with gE; this complex displays Fc receptor activity (binds to  the Fc region of immunoglobulin)  . Glycoproteins are also important  in the production of virus-neutralising antibodies and cell mediated  immunity  . The alphaherpesvirinae have a dsDNA gnome and have no RNA stage during viral replication.. 
+PF01528 Herpesvirus glycoprotein M<br>Pfam-B_929 (release 4.0). The herpesvirus glycoprotein M (gM) is an integral membrane protein predicted to contain 8 transmembrane segments  . Glycoprotein M is not essential for viral replication  .. 
+PF01537 Herpesvirus glycoprotein D/GG/GX domain<br>Pfam-B_603 (release 4.0). This domain is found in several Herpes viruses glycoproteins. This is a family includes glycoprotein-D (gD or gIV) which is common to herpes simplex virus types 1 and 2, as well as equine herpes, bovine herpes and Marek's disease virus. Glycoprotein-D has been found on the viral envelope and the plasma membrane of infected cells. and gD immunisation can produce an immune response to bovine herpes virus (BHV-1). This response is stronger than that of the other major glycoproteins gB (gI) and gC (gIII) in BHV-1.  Glycoprotein G (gG)is one of the seven external glycoproteins of HSV1 and HSV2. This family also contains the glycoprotein GX, (gX), initially identified in Pseudorabies virus.. 
+PF02489 Herpesvirus glycoprotein H<br>Pfam-B_1142 (release 5.4). Herpesvirus glycoprotein H (gH) is a virion associated envelope glycoprotein  . Complex formation between gH and gL has been demonstrated in both virions and infected cells  .. 
+PF02689 Helicase<br>Pfam-B_607 (release 5.5). This family consists of Helicases from the Herpes viruses. Helicases are responsible for the unwinding of DNA and are essential for replication and completion of the viral life cycle.. 
+PF03324 Herpesvirus DNA helicase/primase complex associated protein<br>Pfam-B_3676 (release 6.5) & Pfam-B_4951 (release 14.0). This family includes  HSV UL8, EHV-1 54, VZV 52 AND HCMV 102.. 
+PF03585 Herpesvirus ICP4-like protein C-terminal region<br>Pfam-B_1422 (release 7.0). The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection.  ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer.  ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region  .. 
+PF03584 Herpesvirus ICP4-like protein N-terminal region<br>Pfam-B_1422 (release 7.0). The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection.  ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer.  ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerisation  .. 
+PF03361 Herpes virus intermediate/early protein 2/3<br>Pfam-B_2178 (release 6.6). These viral sequences are similar to UL117 protein of human  and chimpanzee cytomegalovirus, and to intermediate/early  proteins 2 and 3 of certain herpes viruses. UL117 is thought  to be a glycoprotein that is expressed at early and late times after infection  . This region is close to the C-terminus of the protein and may be a transmembrane region  .. 
+PF03363 Herpesvirus leader protein<br>Pfam-B_1664 (release 6.6). 
+PF03122 Herpes virus major capsid protein<br>Pfam-B_600 (release 6.5). This family represents the major capsid protein (MCP) of herpes viruses. The capsid shell consists of 150 MCP hexamers and 12 MCP pentamers. One pentamer is found at each of the 12 apices of the icosahedral shell, and the hexamers form the edges and 20 faces  .. 
+PF04797 Herpesvirus dUTPase protein<br>Pfam-B_6280 (release 7.5). 
+PF02399 Origin of replication binding protein<br>Pfam-B_1518 (release 5.4). This Pfam family represents the herpesvirus origin of replication binding protein, probably involved in DNA replication.. 
+PF03325 Herpesvirus polymerase accessory protein<br>Pfam-B_3097 (release 6.5). The same proteins are also known as polymerase processivity factors.. 
+PF04846 Herpesvirus pp38 phosphoprotein<br>Pfam-B_4545 (release 7.6). This protein represents a conserved region found in most herpesvirus pp38 phosphoproteins.. 
+PF04637 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)<br>Pfam-B_5418 (release 7.5). This family includes UL25 proteins from HCMV, as well as U14 proteins from HHV 6 and HHV7. These 85 kD phosphoproteins appear to act as structural antigens, but their precise function is otherwise unknown.. 
+PF03326 Herpesvirus transcription activation factor (transactivator)<br>Pfam-B_3658 (release 6.5). This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.. 
+PF04843 Herpesvirus tegument protein, N-terminal conserved region<br>Pfam-B_3992 (release 7.6). 
+PF04523 Herpes virus tegument protein U30<br>This family is named after the human herpesvirus protein, but has been characterised in cytomegalovirus as UL47. Cytomegalovirus UL47 is a component of the tegument, which is a protein layer surrounding the viral capsid. UL47 co-precipitates with UL48 and UL69 tegument proteins, and the major capsid protein UL86.  A UL47-containing complex is thought to be involved in the release of viral DNA from the disassembling virus particle  .. 
+PF04541 Herpesvirus virion protein U34    <br>The virion proteins in this family include membrane phosphoprotein-like proteins such as UL34, Epstein-Barr and R50, from dsDNA viruses, no RNA stage, Herpesvirales. The family Herpes_BFRF1, Pfam:PF05900, has been merged in.. 
+PF04533 Herpes virus U44 protein<br>This is a family of proteins from dsDNA beta-herpesvirinae and gamma-herpesvirinae viruses. The function is not known, and the proteins are named variously as U44, BSRF1, UL71, and M71. The family BSRF1 has been merged into this.. 
+PF04529 Herpesvirus U59 protein   <br>The proteins in this family have no known function.  Cytomegalovirus UL88 is also a member of this family.. 
+PF03580 Herpesvirus UL14-like protein<br>Pfam-B_2982 (release 7.0). This is a family of Herpesvirus proteins including UL14. UL14 protein is a minor component of the virion tegument   and is expressed late in infection. UL14 protein can influence the intracellular localisation patterns of a number of proteins belonging to the capsid or the DNA encapsidation machinery  .. 
+PF04559 Herpesvirus UL17 protein<br>UL17 protein is required for DNA cleavage and packaging in herpes viruses. It has been shown to associate with immature B-type capsids  , and is required for the the localisation of capsids and capsid proteins to the intranuclear sites where viral DNA is cleaved and packaged  . In the virion, UL17 is a component of the tegument, which is a protein layer surrounding the viral capsid  .. 
+PF04544 Herpesvirus egress protein UL20<br>UL20 is predicted to be a transmembrane protein with multiple membrane spans.  It is involved in the trans-cellular transport of enveloped virions, and is therefore important for viral egress.  However, UL20 operates in different cellular compartments and different stages of egress in pseudorabies virus and herpes simplex virus.  This is thought to be due to differences in egress pathways between these two viruses  .. 
+PF01646 Herpes virus protein UL24<br>Pfam-B_946 (release 4.1). This family consists of various herpes virus proteins; the gene 20 product, U49 protein, UL24 protein and BXRF1. The UL24 gene (product of the 24th ORF) is not essential for virus  replication, mutants with lesions in UL24 show a reduced ability to  replicate in tissue culture and have reduced thymidine kinase activity as the UL24 gene overlaps with thymidine kinase  .. 
+PF02760 HIN-200/IF120x domain<br>This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain Pfam:PF02758.. 
+PF03369 Herpesvirus UL3 protein<br>Pfam-B_2492 (release 6.6). 
+PF02718 Herpesvirus UL31-like protein<br>Pfam-B_1786 (release 5.5). This is a family of Herpesvirus proteins including UL31 (Swiss:P10215), UL53 (Swiss:P16794), and the  product of ORF 69 in some strains (e.g. Swiss:O36420). The proteins in this family have no known function.. 
+PF03581 Herpesvirus UL33-like protein<br>Pfam-B_1115 (release 7.0). This is a family of Herpesvirus proteins including UL33 Swiss:P10217 ,UL51 Swiss:P16792. The proteins in this  family are involved in packaging viral DNA.. 
+PF03586 Herpesvirus UL36 tegument protein<br>Pfam-B_3425 (release 7.0). The UL36 open reading frame (ORF) encodes the largest herpes simplex virus type 1 (HSV-1) protein, a 270-kDa polypeptide designated VP1/2, which is also a component of the virion tegument. A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells  . This family only covers a small central part of this large protein.. 
+PF03277 Herpesvirus UL4 family<br>Pfam-B_4461 (release 6.5). 
+PF05072 Herpesvirus UL43 protein<br>Pfam-B_5928 (release 7.7). UL43 genes are expressed with true-late (gamma2) kinetics and have been identified as a virion tegument component  .. 
+PF03387 Herpesvirus UL46 protein<br>Pfam-B_2545 (release 6.6). 
+PF03362 Herpesvirus UL47 protein<br>Pfam-B_2182 (release 6.6). 
+PF04823 Herpes_UL49; <br>Herpesvirus UL49 tegument protein. Pfam-B_3850 (release 7.6). 
+PF04540 Herpesvirus UL51 protein<br>UL51 protein is a virion protein. In pseudorabies virus, UL51 (Swiss:Q85227) was identified as a component of the capsid  . In herpes simplex virus type 1 there is evidence for post-translational modification of UL51  .. 
+PF04537 Herpesvirus UL55 protein<br>In infected cells, UL55 is associated with the nuclear matrix, and found adjacent to compartments containing the capsid protein ICP35.  UL55 was not detected in assembled virions. It is thought that UL55 may play a role in virion assembly or maturation  .. 
+PF04534 Herpesvirus UL56 protein<br>In herpes simplex virus type 2, UL56 is thought to be a tail-anchored type II membrane protein involved in vesicular trafficking.  The C terminal hydrophobic region is required for association with the cytoplasmic membrane, and the N terminal proline-rich region is important for the translocation of UL56 to the Golgi apparatus and cytoplasmic vesicles  .. 
+PF01763 Herpesvirus UL6 like<br>Pfam-B_878 (release 4.2). This family consists of various proteins from the herpesviridae that are similar to herpes simplex virus type I UL6 virion protein. UL6 is essential for cleavage and packaging of the viral genome  .. 
+PF01677 Herpesvirus UL7 like<br>Pfam-B_1086 (release 4.1). This family consists of various functionally undefined proteins from the herpesviridae and UL7 from bovine herpes virus [1,2]. UL7 is not essential for virus replication in cell culture, and is found localised in the cytoplasm of infected cells accumulated around the nucleus but could not be detected in purified virions  .  Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication.. 
+PF03554 gpUL73; <br>UL73 viral envelope glycoprotein  . Pfam-B_3001 (release 7.0). This family groups together the viral proteins BLRF1, U46, 53, and  UL73.  The UL73-like envelope glycoproteins, which associates in a  high molecular mass complex with its counterpart, gM, induce neutralising antibody responses in the host.  These glycoprotein are  highly  polymorphic, particularly in the N-terminal region  .. 
+PF01802 Herpesvirus VP23 like capsid protein<br>Pfam-B_1435 (release 4.2). This family consist of various capsid proteins from members  of the herpesviridae. The capsid protein VP23 in herpes simplex virus forms a triplex together with VP19C these fit between and link together adjacent capsomers as formed by VP5 and VP26  . VP3 along with the scaffolding proteins helps to form normal capsids by defining the curvature of the shell and size of the particle  .. 
+PF03327 Herpesvirus capsid shell protein VP19C<br>Pfam-B_3451 (release 6.5). 
+PF01521 HesB-like;HesB; <br>Iron-sulphur cluster biosynthesis. Pfam-B_518 (release 4.0). This family is involved in iron-sulphur cluster biosynthesis  . Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins    .. 
+PF02444 HEV_ORF2; <br>Hepatitis E virus ORF-2 (Putative capsid protein). Pfam-B_1896 (release 5.4). The Hepatitis E virus (HEV) genome is a single-stranded, positive-sense RNA molecule of approximately 7.5 kb  . Three open reading frames (ORF) were identified within the HEV genome: ORF1 encodes non-structural proteins, ORF2 encodes the putative structural protein(s)  , and ORF3 encodes a protein of unknown function. ORF2 contains a consensus signal peptide sequence at its amino terminus and a capsid-like region with a high content of basic amino acids similar to that seen with other virus capsid proteins  .. 
+PF02455 Hexon-associated protein (IIIa)<br>Pfam-B_2076 (release 5.4). The major capsid protein of the adenovirus strain is also known  as a hexon. This is a family of hexon-associated proteins (protein IIIa).. 
+PF00349 hexokinase; <br>Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF03727.  Some members of the family have two copies of each of these domains.. 
+PF03727 hexokinase2; <br>Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF00349. Some members of the family have two copies of each of these domains.. 
+PF03559 NDP-hexose 2,3-dehydratase<br>Pfam-B_1070 (release 7.0). This family includes a range of proteins from antibiotic production pathways. The family includes gra-ORF27 Swiss:Q9ZA32 product that probably functions at an early step, most likely as a dTDP-4-keto-6- deoxyglucose-2,3-dehydratase  . Its homologues include dnmT from the daunorubicin biosynthetic gene cluster in S. peucetius  , a similar gene from the daunomycin biosynthetic cluster in Streptomyces sp. strain C5 Swiss:Q53880   , eryBVI from the erythromycin cluster in S. erythraea and snoH from the nogalamycin cluster in S. nogalater. The proteins in this family are composed of two copies of a 200 amino acid long unit that may be a structural domain.. 
+PF04209 homogentisate 1,2-dioxygenase<br>TIGRFAMs (release 2.0);. Homogentisate dioxygenase cleaves the aromatic ring during the  metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria.  The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangement comprised of a dimer of trimers. The active site iron ion is  coordinated near the interface between the trimers  .. 
+PF01085 Hedgehog amino-terminal signalling domain<br>Pfam-B_1424 (release 3.0). For the carboxyl Hint module, see Pfam:PF01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.. 
+PF00730 Endonuclease_3; <br>HhH-GPD superfamily base excision DNA repair protein. Pfam-B_854 (release 2.1). This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate  . This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases such as Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7 also contains a related domain   that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.. 
+PF03753 Human herpesvirus 6 immediate early protein <br>Pfam-B_1006 (release 7.0). The proteins in this family are poorly characterised, but an investigation  has indicated that the immediate early protein is required the down-regulation of MHC class I expression in dendritic cells. Human herpesvirus 6 immediate early protein is also referred to as U90.. 
+PF03486 HI0933-like protein<br>
+PF04588 Hypoxia induced protein conserved region<br>Pfam-B_4868 (release 7.5). This family is found in proteins thought to be involved in the response to hypoxia.  Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identified.  This region is found at the N-terminus of the member proteins which are predicted to be transmembrane  .. 
+PF01355 High potential iron-sulfur protein<br>
+PF00713 Hirudin<br>Pfam-B_707 (release 2.1). 
+PF02098 Tick histamine binding protein<br>
+PF00977 Histidine biosynthesis protein<br>Pfam-B_1089 (release 3.0). Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes.  The enzymes in this Pfam entry are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. The structure of HisA is known to be a TIM barrel fold.  In some archaeal HisA proteins the TIM barrel is composed of two tandem repeats of a half barrel e.g. Swiss:P05325  . This family belong to the common phosphate binding site TIM barrel family  .. 
+PF00815 Histidinol dehydrogenase<br>Pfam-B_1358 (release 2.1). 
+PF00125 histone; <br>Core histone H2A/H2B/H3/H4. 
+PF01230 HIT domain<br>Prosite & Pfam-B_8474 (Release 8.0). 
+PF00816 H-NS histone family<br>Pfam-B_1651 (release 2.1). 
+PF01870 DUF50;<br>Archaeal holliday junction resolvase (hjc). This family of archaebacterial proteins are holliday junction resolvases (hjc gene)  . The Holliday junction is an essential intermediate of homologous recombination. This protein is the archaeal equivalent of RuvC but is not sequence similar.. 
+PF02110 Hydroxyethylthiazole kinase family<br>
+PF03865 HlyB; <br>Haemolysin secretion/activation protein ShlB/FhaC/HecB. This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein  . . 
+PF02794 RTX toxin acyltransferase family<br>Pfam-B_1230 (Pfam 6.0). Members of this family are enzymes EC:2.3.1.-. involved in fatty acylation of the protoxins (HlyA) at lysine residues, thereby converting them to the active toxin. Acyl-acyl carrier protein (ACP) is the essential acyl donor.  This family show a number of conserved residues that are possible candidates for participation in acyl transfer. Site-directed mutagenesis of the single conserved histidine residue in Swiss:P06736 resulted in complete inactivation of the enzyme  .. 
+PF00529 HlyD family secretion protein<br>MRC-LMB Genome group. 
+PF03201 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase<br>Pfam-B_2929 (release 6.5). 
+PF01101 HMG14 and HMG17<br>
+PF00505 HMG_box; MaoC_dehydrat_N;<br>HMG (high mobility group) box. Pfam-B_8 (release 1.0). 
+PF01154 HMG_CoA_synt; <br>Hydroxymethylglutaryl-coenzyme A synthase N terminal. 
+PF00682 HMGL-like<br>Pfam-B_71 (release 2.1). This family contains a diverse set of enzymes.  These include various aldolases and a region of pyruvate carboxylase. . 
+PF00423 Haemagglutinin-neuraminidase<br>Pfam-B_171 (release 1.0). 
+PF04814 Hepatocyte nuclear factor 1 (HNF-1), N terminus<br>Pfam-B_2624 (release 7.6). This family consists of the N terminus of homeobox-containing transcription factor HNF-1.  This region contains a dimerisation sequence   and an  acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3)  .. 
+PF04813 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus<br>Pfam-B_2624 (release 7.6). This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform.  Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing.\. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms  . Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3)  .. 
+PF04812 Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus<br>Pfam-B_2624 (release 7.6). This family consists of a region found within the alpha isoform and at  the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1.  Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative  splicing.  The C-terminal region of HNF-1 is responsible for the  activation of transcription  . Mutations and polymorphisms in HNF-1  cause the type 3 form of maturity-onset diabetes of the young (MODY3)  .. 
+PF01844 HNH endonuclease<br>
+PF01848 Hok/gef family<br>
+PF05102 holin_BlyA; <br>TIGRFAMs (release 2.0);. BlyA, a small holin found in Borrelia circular plasmids that is  encoded by a prophage.  BlyA contains two largely hydrophobic  helices and a highly charged C-terminus and is membrane  associated  .. 
+PF05204 Homing endonuclease<br>Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life.. 
+PF05203 Hom_end-associated Hint<br>Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce   revealed two domains: an endonucleolytic centre resembling the C-terminal domain of Drosophila melanogaster Hedgehog protein, and a  a second domain containing the protein-splicing active site. This Domain corresponds to the latter protein-splicing domain.. 
+PF00046 homeobox; <br>
+PF00742 Homoserine dehydrogenase<br>Pfam-B_459 (release 2.1). 
+PF00103 hormone; <br>Somatotropin hormone family. 
+PF00123 hormone2; <br>This family contains glucagon, GIP, secretin and VIP.. 
+PF00159 hormone3; <br>Pancreatic hormone peptide. 
+PF00220 hormone4; <br>Neurohypophysial hormones, N-terminal Domain. C-terminal is in hormone5. 
+PF00184 hormone5; <br>Neurohypophysial hormones, C-terminal Domain. N-terminal Domain is in hormone5. 
+PF00236 hormone6; <br>Glycoprotein hormone. 
+PF04617 Hox9 activation region    <br>This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex  .. 
+PF01856 Helicobacter outer membrane protein<br>Pfam-B_395 (release 4.2). This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins  .. 
+PF02521 Putative outer membrane protein<br>Pfam-B_1230 (release 5.4). This family consists of putative outer membrane proteins from  Helicobacter pylori (campylobacter pylori). . 
+PF03328 HpcH/HpaI aldolase/citrate lyase family<br>Pfam-B_3076 (release 6.5) & Pfam-B_2811 (release 14.0). This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.. 
+PF04982 HPP family<br>These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.. 
+PF01288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)<br>
+PF02603 Hpr_kinase; <br>HPr Serine kinase N terminus. This family represents the N-terminal region of Hpr Serine/threonine kinase PtsK.  This kinase is the sensor in a multicomponent phospho-relay system in control of carbon catabolic repression in bacteria  .  This kinase in unusual in that it recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating enzymes  . X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller. The blades are formed by two N-terminal domains each, and the compact central hub assembles the C-terminal kinase domains  .. 
+PF01627 Hpt domain<br>Pfam-B_971 (release 4.1). The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined  . The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to  contain a binding surface for Ssk1p (response regulator receiver domain containing protein Pfam:PF00072)  .. 
+PF01628 HrcA protein C terminal domain<br>Pfam-B_1133 (release 4.1). HrcA is found to negatively regulate the transcription of heat shock genes [1,2]. HrcA contains an amino terminal helix-turn-helix domain, however this corresponds to the carboxy terminal domain.. 
+PF04877 HrpZ;<br>Pfam-B_6141 (release 7.6). HrpZ from the plant pathogen Pseudomonas syringae binds to lipid bilayers and forms a cation-conducting pore in vivo.  This pore-forming activity may allow nutrient release or delivery of virulence factors during bacterial colonisation of host plants  . The family of hairpinN proteins, Harpin, has been merged into this family. HrpN is a virulence determinant which elicits lesion formation in Arabidopsis and tobacco and triggers systemic resistance in Arabidopsis  .. 
+PF02218 Repeat in HS1/Cortactin<br>Pfam-B_5631 (Release 5.2). The function of this repeat is unknown. Seven copies are found in cortactin Swiss:Q14247 and four copies are found in HS1 Swiss:P14317. The repeats are always found amino terminal to an SH3 domain Pfam:PF00018.. 
+PF00447 HSF-type DNA-binding<br>
+PF00011 Hsp20/alpha crystallin family<br>
+PF01430 Hsp33 protein<br>Hsp33 is a molecular chaperone, distinguished from all other known chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localised protein with highly reactive cysteines that respond quickly to changes in the redox environment. Oxidising conditions like H2O2 cause disulfide bonds to form in Hsp33, a process that leads to the activation of its chaperone function  .. 
+PF00012 Hsp70 protein<br>Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release.  Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.. 
+PF00183 Hsp90 protein<br>
+PF04119 Heat shock protein 9/12<br>Pfam-B_14318 (release 7.3);. These heat shock proteins (Hsp9 and Hsp12) are strongly expressed, an increase of 100 fold, upon entry into stationary phase in yeast [1,2].. 
+PF04213 Htaa; <br>This domain is found in HtaA, a secreted protein implicated in iron acquisition and transport  .. 
+PF00126 Bacterial regulatory helix-turn-helix protein, lysR family<br>
+PF04967 HTH DNA binding domain<br>
+PF01022 HTH_ArsR_family;<br>Bacterial regulatory protein, arsR family. Pfam-B_139 (release 3.0). Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.. 
+PF01418 Helix-turn-helix domain, rpiR family<br>Pfam-B_3373 (release 2.1). This domain contains a helix-turn-helix motif  . The best characterised member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.. 
+PF02796 Helix-turn-helix domain of resolvase<br>
+PF00165 HTH_2; <br>Bacterial regulatory helix-turn-helix proteins, AraC family. In the absence of arabinose, the N-terminal arm of AraC  binds to the DNA binding domain (Pfam:PF00165) and helps to hold the two DNA binding domains in a relative  orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerisation domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilised when AraC activates transcription, and  hence AraC ceases looping the DNA when arabinose is added [1-2].. 
+PF04204 Homoserine O-succinyltransferase <br>TIGRFAMs (release 2.0);. 
+PF04955 HupE / UreJ protein<br>This family of proteins are hydrogenase / urease accessory proteins.  The alignment contains many conserved histidines that are likely to be involved in nickel binding. The members usually have five membrane-spanning regions.. 
+PF01455 HupF/HypC family<br>Prodom_3112 (release 99.1). 
+PF04809 HupH hydrogenase expression protein, C-terminal conserved region<br>Pfam-B_3701 (release 7.6). This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown  .. 
+PF01750 Hydrogenase maturation protease<br>Pfam-B_548 (release 4.2). The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal  .. 
+PF01968 Hydantoinase; <br>Hydantoinase/oxoprolinase. This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds  .. 
+PF02538 Hydantoinase B/oxoprolinase<br>This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase (Swiss:P97608) EC:3.5.2.9 which catalyses the formation of L-glutamate from  5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to Pfam:PF01968.. 
+PF01185 Fungal hydrophobin<br>
+PF01155 Hydrogenase expression/synthesis hypA family<br>Four conserved cysteines lie either side of the least conserved region.. 
+PF01924 Hydrogenase formation hypA family<br>HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas  .. 
+PF02494 HYR domain<br>This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat.  This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion  .. 
+PF01608 I/LWEQ domain<br>I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin Swiss:P26039 and yeast Sla2p Swiss:P33338 interact with F-actin  . I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB Swiss:P54633 and SLA110; (3) metazoan Hip1p Swiss:O00291; and (4) yeast Sla2p Swiss:P33338. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks  .. 
+PF04568 Mitochondrial ATPase inhibitor, IATP<br>ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation   ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface.  It is thought to inhibit ATP synthesis by preventing the release of ATP  . The minimum inhibitory region for bovine inhibitor (Swiss:P01096) is from residues 39 to 72  . The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH , the inhibitor forms a dimer via antiparallel coiled coil interactions between the C terminal regions of two monomers.\. At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity  .. 
+PF01749 Importin beta binding domain<br>Pfam-B_544 (release 4.2). This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates  formation of the importin alpha beta complex; required for classical  NLS import of proteins into the nucleus, through the nuclear pore  complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain  .. 
+PF03617 IBV 3A protein <br>Pfam-B_3183 (release 7.0). The gene product of gene 3 from Avian infectious bronchitis virus. Currently, the function of this protein remains unknown.. 
+PF03622 IBV 3B protein <br>Pfam-B_3190 (release 7.0). Product of ORF 3B from Avian infectious bronchitis virus (IBV). Currently, the function of this protein remains unknown  .. 
+PF03620 IBV 3C protein<br>Pfam-B_3232 (release 7.0). Product of ORF 3C from Avian infectious bronchitis virus (IBV). Currently, the function of this protein remains unknown.. 
+PF04629 Islet cell autoantigen ICA69, C-terminal domain<br>Pfam-B_5314 (release 7.5). This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus  . Its precise function is unknown.. 
+PF03921 ICAM_N-terminal;<br>Intercellular adhesion molecule (ICAM), N-terminal domain. ICAMs normally functions to promote intercellular adhesion and  signalling. However, The N-terminal domain of the receptor binds to the  rhinovirus 'canyon' surrounding the icosahedral 5-fold axes,  during the viral attachment process  . This family is a family that is part of the Ig superfamily and is therefore related to the family ig (Pfam:PF00047). . 
+PF00818 Ice nucleation protein repeat<br>Pfam-B_2 (release 3.0). 
+PF00656 ICE_p20; <br>
+PF00463 Isocitrate lyase family<br>
+PF03517 ICln_channel;<br>Regulator of volume decrease after cellular swelling. Griffiths-Jones SR, Coggill P. ICln is a ubiquitously expressed multi-functional protein that plays a critical role in regulating volume decrease in cells after cellular swelling. In plants, ICln induces Cl- currents [1,4,5], thus regulating Cl- homoeostasis in eukaryotes [2,3]. Structurally, the fold resembles a pleckstrin homology fold, on of whose roles is to recruit and tether their host protein to the cell membrane; and although the surface charges of the ICln fold are not equivalent to those of the PH domain, ICln can be phosphorylated in vitro and the PH-nature of the domain may be the part involving it in the transposition from cytosol to cell membrane during cytotonic swelling  .. 
+PF04140 Isoprenylcysteine carboxyl methyltransferase (ICMT) family <br>Pfam-B_15304 (release 7.3) & Pfam-B_5114 (Release 8.0). The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology  .. 
+PF03971 Monomeric isocitrate dehydrogenase<br>NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes  .. 
+PF01231 Indoleamine 2,3-dioxygenase<br>
+PF02479 IE68; <br>Herpesvirus immediate early protein. Pfam-B_2276 (release 5.4). This regulatory protein is expressed from an immediate early gene in the cell cycle of herpesvirus. The protein is known by various names  including IE-68, US1, ICP22 and IR4.. 
+PF01008 Initiation factor 2 subunit family<br>Pfam-B_1302 (release 3.0). This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterised as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The  crystal structure of Ypr118w, a non-essential, low-copy number gene  product from Saccharomyces cerevisiae, reveals a dimeric protein with  two domains and a putative active site cleft  .. 
+PF00707 IF3; <br>Translation initiation factor IF-3, C-terminal domain. Pfam-B_629 (release 2.1). 
+PF01652 Eukaryotic initiation factor 4E<br>Pfam-B_1315 (release 4.1). 
+PF00932 IF_C_term; IF_tail;<br>The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated  hydrolases of the metallo-beta-lactamase,synaptojanin, and  calcineurin-like phosphoesterase superfamilies  .. 
+PF00714 Interferon gamma<br>Pfam-B_615 (release 2.1). 
+PF00047 Immunoglobulin domain<br>Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases.  Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.. 
+PF02395 IGA1; <br>Immunoglobulin A1 protease. Pfam-B_540 (release 5.2). This family consists of immunoglobulin A1 protease proteins.  The immunoglobulin A1 protease cleaves immunoglobulin IgA and is found in pathogenic bacteria such as Neisseria gonorrhoeae  . Not all of the members of this family are IgA proteases Swiss:O32555 from E. coli O157:H7 cleaves human coagulation factor V   and Swiss:O88093 is a hemoglobin protease from E. coli EB1  .. 
+PF00219 Insulin-like growth factor binding protein<br>
+PF01378 B domain<br>This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.. 
+PF00475 Imidazoleglycerol-phosphate dehydratase<br>
+PF00218 Indole-3-glycerol phosphate synthase<br>
+PF05049 Interferon-inducible GTPase (IIGP)<br>Pfam-B_5519 (release 7.7). Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localises to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing  .. 
+PF00340 interleukin-1; <br>This family includes interleukin-1 and interleukin-18.. 
+PF00726 Interleukin 10<br>Pfam-B_885 (release 2.1). 
+PF03039 Interleukin-12 alpha subunit<br>Pfam-B_2071 (release 6.4). Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit (e.g. Swiss:P29459) and a 40kDa beta subunit (e.g. Swiss:P29460). It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit.  On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses [1,2].. 
+PF02372 Interleukin 15<br>Pfam-B_2545 (release 5.4). Interleukin-15 (IL-15) is a cytokine that possesses a variety of biological functions, including stimulation and maintenance of cellular immune responses  .. 
+PF02394 Interleukin-1 propeptide<br>Pfam-B_1500 (release 5.2). The Interleukin-1 cytokines are translated as precursor proteins.  The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.. 
+PF00715 Interleukin 2<br>Pfam-B_709 (release 2.1). 
+PF02059 Interleukin-3<br>
+PF00727 Interleukin 4<br>Pfam-B_833 (release 2.1). 
+PF02025 Interleukin 5<br>
+PF00489 IL-6; <br>Interleukin-6/G-CSF/MGF family. 
+PF01415 Interleukin 7/9 family<br>Ponting CP, Schultz J, Bork P. IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.. 
+PF00048 il8; <br>Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons  involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.. 
+PF01787 Ilarvirus coat protein<br>Pfam-B_1131 (release 4.2). This family consists of various coat proteins from the ilarviruses part of the Bromoviridae, members include apple mosaic virus and prune dwarf virus. The ilarvirus coat protein is required to initiate replication of the viral genome in host plants  .  Members of the Bromoviridae have a positive stand ssRNA genome with no DNA stage in there replication.. 
+PF01450 Acetohydroxy acid isomeroreductase, catalytic domain<br>Prodom_2380 (release 99.1). Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine.. 
+PF00920 Dehydratase family<br>Pfam-B_1309 (release 3.0). 
+PF05046 Mitochondrial large subunit ribosomal protein (Img2)<br>Pfam-B_17929 (release 7.6). This family of proteins have been identified as part of the mitochondrial large ribosomal subunit in yeast  .. 
+PF04156 IncA protein<br>Pfam-B_2718 (release 7.3). Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions  . This family probably includes members of the wider Inc family rather than just IncA.. 
+PF02387 IncFII RepA protein family<br>Pfam-B_1209 (release 5.2). This protein is plasmid encoded and found to be essential for plasmid replication  .. 
+PF02974 Protease inhibitor Inh<br>The Inh inhibitor is secreted into the periplasm where its presumed physiological function is to protect periplasmic proteins against the action of secreted proteases  . A range of proteases including A, B and C from E. chrysanthemi, alkaline protease from Pseudomonas aeruginosa and the 50 kDa protease from Serratia marcescens are inhibited.. 
+PF00876 Ogre; <br>Pfam-B_779 (release 3.0). This family includes the drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions  . This family has been named the Innexins  .. 
+PF01658 Myo-inositol-1-phosphate synthase<br>Pfam-B_959 (release 4.1). This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated  to inositol  . Inositol phosphates play an important role in  signal transduction.. 
+PF00459 inositol_P; <br>Inositol monophosphatase family. 
+PF03488 Ins_beta_nem; <br>Nematode insulin-related peptide beta type. 
+PF03811 Ins_element1; HTH_Tnp_IS1;<br>InsA N-terminal domain. This appears to be a short zinc binding domain found in IS1 InsA family protein. It is found at the N-terminus of the protein and may be a DNA-binding domain.. 
+PF00049 ins; <br>Insulin/IGF/Relaxin family. Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.. 
+PF00552 integrase; Integrase;<br>Integrase DNA binding domain. Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain.  The central domain is the catalytic domain Pfam:PF00665. This domain is the carboxyl terminal domain that is a non-specific DNA binding domain  .. 
+PF02920 integrase_DNA; <br>DNA binding domain of tn916 integrase. 
+PF00357 integrin_A; <br>Integrin alpha cytoplasmic region. This family contains the short intracellular region of integrin alpha chains.. 
+PF00362 integrin_B; <br>Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer  .  The sequences repeats have been trimmed due to an overlap with EGF.. 
+PF00143 interferon; <br>Interferon alpha/beta domain. 
+PF03487 Interleukin_13; <br>
+PF01348 Type II intron maturase<br>Pfam-B_105 (release 3.0). Group II introns use intron-encoded reverse transcriptase, maturase and DNA endonuclease activities for site-specific insertion into DNA  .  Although this type of intron is self splicing in vitro they require a maturase protein for splicing in vivo. It has been shown that a specific region of the aI2 intron is needed for the maturase function  . This region was found to be conserved in group II introns and called domain X  .. 
+PF03519 Invasion protein B family<br>
+PF04741 InvH outer membrane lipoprotein<br>Pfam-B_3503 (release 7.5). This family represents the Salmonella outer membrane lipoprotein InvH. The molecular function of this protein is unknown, but it is required for the localisation to outer membrane of InvG, which is involved in a type III secretion apparatus mediating host cell invasion [1,2].. 
+PF00904 Involucrin repeat<br>Pfam-B_1158 (release 3.0). 
+PF02121 Phosphatidylinositol transfer protein<br>Along with the structurally unrelated Sec14p family (found in Pfam:PF00650), this family can bind/exchange one molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC) and thus aids their transfer between different membrane compartments. There are three sub-families - all share an N-terminal PITP-like domain, whose sequence is highly conserved. It is described as consisting of three regions. The N-terminal region is thought to bind the lipid and contains two helices and an eight-stranded, mostly antiparallel beta-sheet. An intervening loop region, which is thought to play a role in protein-protein interactions, separates this from the C-terminal region, which exhibits the greatest sequence variation and may be involved in membrane binding. PITP alpha (Swiss:Q00169) has a 16-fold greater affinity for PI than PC. Together with PITP beta (Swiss:P48739), it is expressed ubiquitously in all tissues  .. 
+PF03278 IpaB/EvcA family<br>Pfam-B_4003 (release 6.5). This family includes IpaB, which is an invasion plasmid antigen from  Shigella  , as well as EvcA from E. coli Swiss:Q9ZNF1. Members of this family seem to be involved in pathogenicity of some enterobacteria. However the exact function of this component is not clear.. 
+PF04979 Protein phosphatase inhibitor 2 (IPP-2)<br>Pfam-B_5306 (release 7.6). Protein phosphotase inhibitor 2 (IPP-2) is a phosphoprotein conserved among all eukaryotes, and it appears in both the nucleus and cytoplasm of tissue culture cells .. 
+PF01715 IPP transferase<br>Pfam-B_1875 (release 4.1). This is a family of IPP transferases EC:2.5.1.8 also known as  tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs  at A(37) to give isopentenyl A(37)  .. 
+PF01745 Isopentenyl transferase<br>Pfam-B_2229 (release 4.1). Isopentenyl transferase / dimethylallyl transferase synthesises isopentenyladensosine 5'-monophosphate, a cytokinin that induces shoot formation on host plants  infected with the Ti plasmid  .. 
+PF00605 Interferon regulatory factor transcription factor<br>This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.. 
+PF04120 iron_permease; <br>Low affinity iron permease . Pfam-B_71435 (release 7.3);. 
+PF02060 Slow voltage-gated potassium channel<br>
+PF00180 isodh; <br>Isocitrate/isopropylmalate dehydrogenase. 
+PF04279 Intracellular septation protein A <br>TIGRFAMs (release 2.0);. 
+PF01128 UPF0007;<br>2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. Members of this family are enzymes which catalyse the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from cytidine triphosphate and 2-C-methyl-D-erythritol 4-phosphate (MEP)  .. 
+PF01695 IstB;<br>IstB-like ATP binding protein. Pfam-B_982 (release 4.1). This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences  .  The function of this protein is unknown, but it may perform a transposase function  .. 
+PF02189 Immunoreceptor tyrosine-based activation motif<br>Alignment kindly provided by SMART. 
+PF01156 Inosine-uridine preferring nucleoside hydrolase<br>
+PF04183 IucA / IucC family<br>Pfam-B_1982 (release 7.3). IucA and IucC catalyse discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate  . This family represents the N-terminal region.  The C-terminal region appears to be related to iron transporter proteins.. 
+PF01419 Jacalin-like lectin domain<br>Proteins containing this domain are lectins.  It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein (Swiss:P15501).. 
+PF02375 jmjN; <br>
+PF03957 JNK; <br>Jun-like transcription factor. 
+PF01486 K-box region<br>Pfam-B_25 (release 4.0). The K-box region is commonly found associated with SRF-type transcription factors see Pfam:PF00319. The K-box is a possible coiled-coil structure  . Possible role in multimer formation  .. 
+PF02960 K1 glycoprotein<br>Pfam-B_345 (release 6.4). 
+PF02149 Kinase associated domain 1<br>
+PF02524 KID_repeat; <br>Pfam-B_1382 (release 5.4). This is family contains the KID repeat as found in Borrelia spirochete RepA / Rep+ proteins.  The function of these proteins is unknown. RepA and related Borrelia proteins have been suggested to play an important genus-wide role in the biology of the Borrelia  .. 
+PF00050 kazal; <br>Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family Swiss:P46721.. 
+PF03522 K-Cl Co-transporter type 1 (KCC1)<br>
+PF03520 KCNQ1_channel; <br>KCNQ voltage-gated potassium channel. This family matches to the C-terminal tail of KCNQ type potassium channels.. 
+PF03812 2-keto-3-deoxygluconate permease<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03814 Potassium-transporting ATPase A subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02669 K+-transporting ATPase, c chain<br>This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilise the Kdp complex  .  It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA  .  The K+ transport system actively transports K+ ions via ATP hydrolysis.. 
+PF02702 Osmosensitive K+ channel His kinase sensor domain<br>This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport  .  The aligned region corresponds to the N-terminal cytoplasmic part of the protein which may be  the sensor domain responsible for sensing turgor pressure  .. 
+PF04962 KduI/IolB family<br>COG3717 & Pfam-B_11840 (release 10.0). This family includes the 5-keto 4-deoxyuronate isomerase enzyme EC:5.3.1.17 that is involved in pectin degradation. This family aldo includes bacterial Myo-inositol catabolism (IolB) proteins. The Bacillus subtilis inositol operon (iolABCDEFGHIJ) is involved in myo-inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction system mediated by IolR  . The exact function of IolB is unknown. Members of this family possess a Cupin like structure.. 
+PF02422 Keratin<br>Pfam-B_1920 (release 5.4). This family represents avian keratin proteins  , found in feathers, scale and claw.. 
+PF01500 Keratin, high sulfur B2 protein<br>Pfam-B_706 (release 4.0). High sulfur proteins are cysteine-rich proteins synthesised during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments  . This family has been divided up into four regions, with the second region containing 8 copies of a short repeat  . This family is also known as B2 or KAP1.. 
+PF04579 Keratin, high-sulphur matrix protein<br>Pfam-B_4676 (release 7.5). Family of Keratin, high-sulfur matrix proteins.  The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulphur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas microfibrils contain the larger, low-sulphur keratins (40-56 kDa)  .. 
+PF03882 KicB killing factor<br>The kicA and kicB genes are found upstream of mukB. It has been suggested that the kicB gene encodes a killing factor and the kicA gene codes for a protein that suppresses the killing function of the kicB gene product  . It was also demonstrated that KicA and KicB can function as a post-segregational killing system, when the genes are transferred from the E. coli chromosome onto a plasmid  .. 
+PF04383 KilA-N domain<br>The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease  .. 
+PF02172 KIX domain<br>Pfam-B_4149 (Release 4.2). CBP and P300 bind to the CREB via a domain known as KIX  . The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.. 
+PF03037 Kinetoplastid membrane protein 11<br>Pfam-B_1062 (release 6.4). Kinetoplastid membrane protein 11 is a major cell surface glycoprotein  of the parasite Leishmania donovani.. 
+PF03790 KNOX1 domain <br>Pfam-B_533 (release 7.0). The MEINOX region is comprised of two domains, KNOX1 and KNOX2.  KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerisation  . . 
+PF03791 KNOX2 domain <br>Pfam-B_533 (release 7.0). The MEINOX region is comprised of two domains, KNOX1 and KNOX2.  KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerisation  . . 
+PF00051 kringle; <br>Swissprot_feature_table. Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.. 
+PF00197 Trypsin and protease inhibitor<br>
+PF02442 L1L_F9_C19; <br>Lipid membrane protein of large eukaryotic DNA viruses. Pfam-B_1868 (release 5.4), Iyer L. The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV, have all been shown to have a lipid membrane, in spite of the major differences in virion structure. The paralogous genes L1R and F9L encode membrane proteins that have a conserved domain architecture, with a single, C-terminal transmembrane helix, and an N-terminal, multiple-disulfide-bonded domain. The conservation of the myristoylated, disulfide-bonded protein L1R/F9L in most of the NCLDV correlates with the conservation of the thiol-disulfide oxidoreductase E10R which, in vaccinia virus, is required for the formation of disulfide bonds in L1R and F9L  .. 
+PF05047 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain <br>Pfam-B_9461 (release 7.6). The proteins in this family are located in the  mitochondrion. The family includes ribosomal protein L51, and S25. This family also includes mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) EC:1.6.5.3. It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins.. 
+PF04604 Type-A lantibiotic<br>Pfam-B_4608 (release 7.5). Lantibiotics are antibiotic peptides distinguished by the presence of the rare thioether amino acids lanthionine and/or methyl-lanthionine. They are produced by Gram-positive bacteria as gene-encoded precursor peptides and undergo post-translational modification to generate the mature peptide. Based on their structural and functional features lantibiotics are currently divided into two major groups: the flexible amphiphilic type-A and the rather rigid and globular type-B. Type-A lantibiotics act primarily by pore formation in the bacterial membrane by a mechanism involving the interaction with specific docking molecules such as the membrane precursor lipid II  .. 
+PF02502 Ribose/Galactose Isomerase<br>Pfam-B_1105 (release 5.4). This family of proteins contains the sugar isomerase enzymes ribose  5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). . 
+PF00356 lacI; <br>Bacterial regulatory proteins, lacI family. 
+PF02450 LACT;<br>Lecithin:cholesterol acyltransferase. Pfam-B_2099 (release 5.4). Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.. 
+PF04369 Lactococcin-like family<br>Family of bacteriocins from lactic acid bacteria.. 
+PF01306 LacY proton/sugar symporter<br>This family is closely related to the sugar transporter family.. 
+PF00961 Intron_maturase; <br>LAGLIDADG endonuclease. 
+PF02264 LamB porin<br>Pfam-B_4810 (release 5.2). Maltoporin (LamB protein) forms a trimeric structure which facilitates the diffusion of maltodextrins across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an antiparallel  beta-barrel  .. 
+PF03746 LamB/YcsF family<br>This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression  . The exact molecular function of the proteins in this family is unknown.. 
+PF02061 Lambda Phage CIII<br>The CIII protein from bacteriophage lambda is an inhibitor of the FtsH peptidase  .. 
+PF00052 laminin_B; <br>Laminin B (Domain IV). Swissprot_feature_table. 
+PF00053 Laminin EGF-like (Domains III and V)<br>Swissprot_feature_table. This family is like Pfam:PF00008 but has 8 conserved  cysteines instead of six.. 
+PF00054 laminin_G; Laminin_G; <br>Swissprot_feature_table. 
+PF00055 laminin_Nterm;<br>Laminin N-terminal (Domain VI). Swissprot_feature_table. 
+PF01299 Lysosome-associated membrane glycoprotein (Lamp)<br>
+PF05147 Lanthionine synthetase C-like protein<br>Pfam-B_6095 (release 7.7). Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs  . Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains  . This region contains seven internal repeats.. 
+PF04738 Lantibiotic dehydratase, C terminus<br>Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides  .  They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin.  Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues  .  This family constitutes the C-terminus of the enzyme proposed to catalyse the dehydration step  , .. 
+PF04737 Lantibiotic dehydratase, N terminus<br>Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides  .  They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin.  Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues  .  This family constitutes the N-terminus of the enzyme proposed to catalyse the dehydration step  , .. 
+PF00500 late_protein_L1; <br>Pfam-B_69 (release 1.0). 
+PF00513 late_protein_L2; <br>Pfam-B_39 (release 1.0). 
+PF02354 Latrophilin Cytoplasmic C-terminal region<br>Pfam-B_874 (release 5.2). This family consists of the cytoplasmic C-terminal region in  latrophilin.  Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin  family of G-protein coupled receptors that are involved in  secretion  .  Latrophilin mRNA is present only in neuronal  tissue  .  Lactrophillin interacts with G-alpha O  .. 
+PF01273 Lipid_binding_gp; <br>LBP / BPI / CETP family, N-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.. 
+PF02886 Lipid_binding_gp; <br>LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.. 
+PF03815 LCCL domain<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04072 Leucine carboxyl methyltransferase<br>Pfam-B_5898 (release 7.3);. Family of leucine carboxyl methyltransferases EC:2.1.1.- . This family may need divides a the full alignment contains a significantly shorter mouse sequence.. 
+PF04792 V antigen (LcrV) protein<br>Pfam-B_6155 (release 7.5). Yersinia pestis, the aetiologic agent of plague, secretes a set of environmentally regulated, plasmid pCD1-encoded virulence proteins termed Yops and V antigen (LcrV) by a type III secretion mechanism. LcrV is a multifunctional protein that has been shown to act at the level of secretion control by binding the Ysc inner-gate protein LcrG and to modulate the host immune response by altering cytokine production.  LcrV is also necessary for full induction of low-calcium response (LCR) stimulon virulence gene transcription.  Family members are not confined to Yersinia pestis [1,2].   . 
+PF00056 ldh; <br>lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family.  Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.. 
+PF02615 ldh_2;<br>Malate/L-lactate dehydrogenase. This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyses  the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyses the reactions: (S)-malate + NAD(+) <=> oxaloacetate  + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.. 
+PF02866 ldh_C; <br>lactate/malate dehydrogenase, alpha/beta C-terminal domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family.  Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.. 
+PF00058 ldl_recept_b; <br>Low-density lipoprotein receptor repeat class B. This domain is also known as the YWTD motif after the most conserved region of the repeat.  The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure  .. 
+PF03760 LEA-group1; <br>Late embryogenesis abundant (LEA) group 1 . Pfam-B_1549 (release 7.0). Family members are conserved along the entire coding region,  especially within the hydrophobic internal 20 amino acid motif, which may be repeated.. 
+PF03168 Late embryogenesis abundant protein<br>Mifsud W, Griffiths-Jones SR. Pfam-B_3080 (release 6.5). Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress.  The function of these proteins is unknown.  This family represents a group of LEA proteins that appear to be distinct from those in Pfam:PF02987. The family DUF1511, Pfam:PF07427, has now been merged into this family.. 
+PF03242 Late embryogenesis abundant protein<br>Pfam-B_3170 (release 6.5). Members of this family are similar to late embryogenesis abundant proteins.\.    Members of the family have been isolated in a number of different screens.  However, the molecular function of these proteins remains obscure.. 
+PF00059 lectin_c; <br>Lectin C-type domain. Swissprot_feature_table. This family includes both long and short form C-type. 
+PF03041 lef-2; <br>Pfam-B_1773 (release 6.4). The lef-2 gene (for late expression factor 2) from baculovirus is required for expression of late genes. This gene has been shown to be specifically required for expression from the vp39 and polh promoters  .  LEF-1 is a DNA primase and there is some evidence to suggest that LEF-2 may bind to both DNA and LEF-1  .. 
+PF03388 Legume-like lectin family<br>Pfam-B_2789 (release 6.6). Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 Swiss:P49256 and ERGIC-53 Swiss:P49257 lectins. These two proteins were the first recognised members of a family of animal lectins similar (19-24%) to the leguminous plant lectins  . The alignment for this family aligns residues lying towards the N-terminus, where the similarity of VIP36 and ERGIC-53 is greatest. However, while Fiedler and Simons   identified these proteins as a new family of animal lectins, our alignment also includes yeast sequences. ERGIC-53 is a 53kD protein, localised to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC). It was identified as a calcium-dependent, mannose-specific lectin  . Its dysfunction has been associated with combined factors V and VIII deficiency OMIM:227300 OMIM:601567, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein- secreting pathway [2,3]. . 
+PF00139 lectin_legB; <br>Legume lectin domain. 
+PF03954 lectin_N; <br>Hepatic lectin, N-terminal domain. 
+PF05098 Late expression factor 4 (LEF-4)<br>Pfam-B_6330 (release 7.7). Late expression factor 4 (LEF-4) is one of the Baculovirus late expression factor proteins. LEF-4 carries out all the enzymatic functions related to  mRNA capping  .. 
+PF04941 Late expression factor 8 (LEF-8)<br>Pfam-B_5130 (release 7.6). Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to the  second largest subunit of prokaryotic DNA-directed RNA polymerase .. 
+PF05094 Late expression factor 9 (LEF-9)<br>Pfam-B_6326 (release 7.7). Late expression factor 9 (LEF-9) is one of the primary components of RNA polymerase produced by baculoviruses. LEF-9 is homologous to the largest beta-subunit of prokaryotic DNA-directed RNA polymerase  .. 
+PF05150 Legionella pneumophila major outer membrane protein precursor<br>Pfam-B_6492 (release 7.7). This family consists of major outer membrane protein precursors from Legionella pneumophila.. 
+PF03020 LEM domain<br>The LEM domain is 50 residues long and is composed of two parallel alpha helices.  This domain is found in inner nuclear membrane proteins. It is called the LEM domain after LAP2 Swiss:Q62733, Emerin Swiss:P50402 and Man1.. 
+PF04011 LemA family<br>The members of this family are related to the LemA protein Swiss:P71452  . LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular  . The exact molecular  function of this protein is uncertain.. 
+PF02998 Lentiviral Tat protein<br>Pfam-B_1519 (release 6.4). This family contains retroviral transactivating (Tat) proteins [1,2], from a variety of Lentiviruses.. 
+PF02024 Leptin<br>
+PF03588 Leucyl/phenylalanyl-tRNA protein transferase<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01819 Levivirus coat protein<br>The Levivirus coat protein forms the bacteriophage coat that encapsidates the viral RNA.  180 copies of this protein form the virion shell. The MS2 bacteriophage coat protein controls two distinct processes: sequence-specific RNA encapsidation and repression of replicase translation-by binding to an RNA stem-loop structure of 19 nucleotides containing the initiation codon of the replicase gene. The binding of a coat protein dimer to this hairpin shuts off synthesis of the viral replicase, switching the viral replication cycle to virion assembly rather than continued replication  .. 
+PF01726 LexA DNA binding domain<br>Pfam-B_1975 (release 4.1). This is the DNA binding domain of the LexA SOS regulon  repressor which prevents expression of DNA repair proteins. The aligned region contains a variant form of the helix-turn-helix DNA  binding motif  . This domain is found associated with Pfam:PF00717 the auto-proteolytic  domain of LexA EC:3.4.21.88.. 
+PF01790 Prolipoprotein diacylglyceryl transferase<br>
+PF00556 Antenna complex alpha/beta subunit<br>
+PF04991 LicD family<br>Pfam-B_5278 (release 7.6). The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent  . These proteins are part of the nucleotidyltransferase superfamily  .. 
+PF01291 LIF / OSM family<br>
+PF00549 ligase-CoA; <br>This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP.. 
+PF00412 LIM domain<br>This family represents two copies of the LIM structural domain.. 
+PF01803 LIM-domain binding protein<br>Pfam-B_1352 (release 4.2). The LIM-domain binding protein, binds to the LIM domain Pfam:PF00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) Swiss:P70662 is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons  . It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development  . The Drosophila protein Chip Swiss:O18353 is required for segmentation and activity of a remote wing margin enhancer  . Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development  . It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions  .. 
+PF00538 linker_histone; <br>linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1  links nucleosomes into higher order structures Histone H1 is replaced  by histone H5 in some cell types.. 
+PF04454 Encapsulating protein for peroxidase<br>The Linocin_M18 is found in eubacteria and archaea [1,2]. These proteins, referred to as encapsulins, form nanocompartments within the bacterium which contain ferritin-like proteins or peroxidases, enzymes involved in oxidative-stress response. These enzymes are targeted to the interior of encapsulins via unique C-terminal extensions  .. 
+PF03583 Secretory lipase <br>Pfam-B_3085 (release 7.0). These lipases are expressed and secreted during the infection cycle of these pathogens.  In particular, C. albicans has  a large number of different lipases, possibly reflecting broad  lipolytic activity, which may contribute to the persistence and  virulence of C. albicans in human tissue  .. 
+PF03279 Bacterial lipid A biosynthesis acyltransferase<br>Pfam-B_1803 (release 6.5). 
+PF00151 lipase; <br>
+PF01674 Lipase (class 2)<br>Pfam-B_968 (release 4.1). This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyse ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol  and free fatty acids  . Swiss:P37957 is a extracellular lipase from B. subtilis 168  .. 
+PF03280 Proteobacterial lipase chaperone protein<br>Pfam-B_4313 (release 6.5). 
+PF00657 GDSL-like Lipase/Acylhydrolase<br>Prosite & Pfam-B_543 (Release 7.5). 
+PF00061 lipocalin; <br>Lipocalin / cytosolic fatty-acid binding protein family. Prosite and HMM_iterative_training. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.. 
+PF00820 Borrelia lipoprotein<br>Pfam-B_1321 (release 2.1). This family of lipoproteins is found in Borrelia spirochetes.  The function of these proteins is uncertain.. 
+PF03202 Putative mycoplasma lipoprotein, C-terminal region<br>Pfam-B_2205 (release 6.5). 
+PF03260 Lepidopteran low molecular weight (30 kD) lipoprotein<br>Pfam-B_4108 (release 6.5). 
+PF03330 Lipoprotein_13;<br>Rare lipoprotein A (RlpA)-like double-psi beta-barrel. Pfam-B_3255 (release 6.5). Rare lipoprotein A (RlpA) contains a conserved region that has the  double-psi beta-barrel (DPBB) fold [3,4]. The function of RlpA is not well understood, but it has been shown to act as a prc mutant suppressor in Escherichia coli  . The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions. Another example of this domain is found in the N terminus of pollen allergen.. 
+PF03640 Secreted repeat of unknown function<br>This family occurs as tandem repeats in a set of lipoproteins. The alignment contains a Y-X4-D motif.. 
+PF04791 LMBR1-like membrane protein<br>Pfam-B_6189 (release 7.5). Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought  . Vertebrate members of this family may play a role in limb development  . A member of this family has been shown to be a lipocalin membrane receptor  . 
+PF03923 Uncharacterized lipoprotein<br>The function of this presumed lipoprotein is unknown. The family includes E. coli YajG Swiss:P36671.. 
+PF04200 Lipoprotein associated domain<br>Pfam-B_3382 (release 7.3). This presumed domain is about 100 amino acids in length. It is found in lipoprotein of unknown function and is greatly expanded in Mycoplasma pulmonis.  The domain is found in up to five copies in some proteins. This family also includes the Mycoplasma arthritidis MAA2 variable surface protein. MAA2 is implicated in in cytoadherence and virulence and has been shown to exhibit both size and phase variability  .. 
+PF00921 Borrelia lipoprotein<br>Pfam-B_1509 (release 3.0). This family of lipoproteins is found in Borrelia spirochetes.  The function of these proteins is uncertain.. 
+PF00938 Lipoprotein; <br>Pfam-B_1076 (release 3.0). This family of lipoproteins is Mycoplasma specific.. 
+PF01298 Transferrin binding protein-like solute binding protein<br>Pfam-B_893 (release 3.0). This family of proteins are distantly related to other families of solute binding proteins.. 
+PF01441 Lipoprotein<br>Prodom_1149 (release 99.1). Members of this family are lipoproteins that are probably involved in evasion of the host immune system by pathogens.. 
+PF01540 Adhesin lipoprotein<br>Pfam-B_615 (release 4.0). This family consists of the p50 and variable adherence-associated antigen (Vaa) adhesins from Mycoplasma hominis. M. hominis is a mycoplasma associated with human urogenital diseases, pneumonia, and septic arthritis  . An adhesin is a cell surface molecule that mediates adhesion to other cells or to the surrounding surface or substrate. The Vaa antigen is a 50-kDa surface lipoprotein that has four tandem repetitive DNA sequences encoding a periodic peptide structure, and is highly immunogenic in the human host  . p50 is also a 50-kDa lipoprotein, having three repeats A,B and C, that may be a tetramer of 191-kDa in its native environment  .. 
+PF02030 Hypothetical lipoprotein (MG045 family)<br>This family includes hypothetical lipoproteins, the amino terminal part of this protein is related to Pfam:PF01547, a family of solute binding proteins. This suggests this family also has a solute binding function.. 
+PF03305 Mycoplasma MG185/MG260 protein<br>Pfam-B_4433 (release 6.5). Most of the aligned regions in this family are found towards the middle of the member proteins.. 
+PF00305 lipoxygenase; <br>
+PF04778 LMP repeated region<br>Pfam-B_2380 (release 7.6). This family consists of a repeated sequence element found in the LMP group of surface-located membrane proteins of Mycoplasma hominis.  The the number of repeats in the protein affects the tendency of cells to spontaneously  aggregate.  Agglutination may be an important factor in colonisation. Non-agglutinating microorganisms might easily be distributed whereas  aggregation might provide a better chance to avoid an antibody response since some of the epitopes may be buried  .. 
+PF01451 Low molecular weight phosphotyrosine protein phosphatase<br>Prodom_2132 (release 99.1). 
+PF03548 Outer membrane lipoprotein carrier protein LolA<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03550 Outer membrane lipoprotein LolB<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04728 Lipoprotein leucine-zipper<br>This is leucine-zipper is found in the enterobacterial outer membrane lipoprotein LPP. It is likely that this domain oligomerises and is involved in protein-protein interactions. As such it is a bundle of alpha-helical coiled-coils, which are known to play key roles in mediating specific protein-protein interactions for in molecular recognition and the assembly of multi-protein complexes.. 
+PF02169 LPP20 lipoprotein<br>This family contains the LPP20 lipoprotein, which is a non-essential class of lipoprotein  .. 
+PF04348 LppC putative lipoprotein<br>This family includes several bacterial outer membrane antigens, whose molecular function is unknown.. 
+PF02684 Lipid-A-disaccharide synthetase<br>This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyse the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl  1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyse the fist disaccharide step in the synthesis of  lipid-A-disaccharide.. 
+PF03331 UDP-3-O-acyl N-acetylglycosamine deacetylase<br>Pfam-B_3666 (release 6.5). The enzymes in this family catalyse the second step in the biosynthetic pathway for lipid A.. 
+PF02606 Tetraacyldisaccharide-1-P 4'-kinase<br>This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130.   This enzyme catalyses the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosam inyl  beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate.  This enzyme is  involved in the synthesis of lipid A portion of the bacterial  lipopolysaccharide layer (LPS)  . The family contains a P-loop motif at the N terminus.. 
+PF03788 LrgA family<br>This family is uncharacterised. It contains the protein LrgA that has been hypothesised to export murein hydrolases  .. 
+PF04172 LrgB-like family <br>TIGRFAMs (release 2.0);. The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance  .. 
+PF01462 Leucine rich repeat N-terminal domain<br>Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.. 
+PF01816 Leucine rich repeat variant<br>The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.. 
+PF05083 LST-1 protein<br>Pfam-B_6166 (release 7.7). B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia  .. 
+PF00677 Lumazine binding domain<br>Pfam-B_291 (release 2.1). This domain binds to derivatives of lumazine  in some proteins. Some proteins have lost the residues involved in binding lumazine.. 
+PF00894 Luteovirus coat protein<br>Pfam-B_123 (release 3.0). 
+PF02122 Luteo_ORF2; <br>This family contains polyprotein processing endopeptidases from RNA viruses.. 
+PF04662 Luteovirus P0 protein<br>Pfam-B_4444 (release 7.5) & Pfam-B_3579 (release 10.0). This family of proteins may be involved in suppression of PTGS a plant defence mechanism  .. 
+PF01659 Luteovirus putative VPg genome linked protein<br>Pfam-B_970 (release 4.1). This family consists of several putative genome linked proteins.  The genomic RNA of luteoviruses are linked to virally encoded genome proteins (VPg).  Open reading frame 4 is thought to encode the VPg  in Soybean dwarf luteovirus  . Luteoviruses have isometric capsids that contain a positive stand ssRNA genome, they have no DNA stage during their replication.. 
+PF04443 Acyl-protein synthetase, LuxE<br>LuxE is an acyl-protein synthetase found in bioluminescent bacteria.  LuxE catalyses the formation of an acyl-protein thioester from a fatty acid and a protein.\.       This is the second step in the bioluminescent fatty acid reduction system, which converts tetradecanoic acid to the aldehyde substrate of the luciferase-catalysed bioluminescence reaction   A conserved cysteine found at position 364 in Photobacterium phosphoreum LuxE (Swiss:Q52100) is thought to be acylated during the transfer of the acyl group from the synthetase subunit to the reductase.  The carboxyl terminal of the synthetase is though to act as a flexible arm to transfer acyl groups between the sites of activation and reduction  . This family also includes Vibrio cholerae RBFN protein (Swiss:Q06961), which is involved in the biosynthesis of the O-antigen component 3-deoxy-L-glycero-tetronic acid.. 
+PF02664 S-Ribosylhomocysteinase (LuxS)<br>This family consists of the LuxS protein involved in autoinducer AI2  synthesis and its hypothetical relatives. S-ribosylhomocysteinase (LuxS) catalyses the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule. . 
+PF00206 lyase_1; <br>
+PF02278 Polysaccharide lyase family 8, super-sandwich domain<br>Pfam-B_4840 (release 5.2). This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.. 
+PF02884 Polysaccharide lyase family 8, C-terminal beta-sandwich domain<br>Pfam-B_4840 (release 5.2). This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.. 
+PF00062 lys; <br>C-type lysozyme/alpha-lactalbumin family. Overington and HMM_iterative_training. Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.. 
+PF01810 LysE type translocator<br>Pfam-B_1537 (release 4.2) & Pfam-B_7916 (Release 8.0). This family consists of various hypothetical proteins and an l-lysine exporter LysE Swiss:P94633 from Corynebacterium glutamicum which is proposed  to be the first of a novel family of translocators  . LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times  . The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of  l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine  .. 
+PF03641 Possible lysine decarboxylase<br>Pfam-B_741 (release 7.0). The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.. 
+PF02402 Lysis protein<br>Pfam-B_1555 (release 5.4). 
+PF04971 Lysis protein S <br>Pfam-B_7633 (release 7.0). The lysis S protein is a cytotoxic protein forming holes in membranes causing cell lysis. The action of Lysis S is independent of the  proportion of acidic phospholipids in the membrane  .. 
+PF01186 Lysyl oxidase <br>
+PF02401 LytB protein<br>Pfam-B_1515 (release 5.4). The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. The LytB gene is involved in the trunk line of the MEP pathway.. 
+PF04397 LytTr DNA-binding domain<br>This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern (see  ). . 
+PF02370 M protein repeat<br>Pfam-B_208 (release 5.2). This short repeat is found in multiple copies in bacterial M proteins. The M proteins bind to IgA and are closely associated with virulence. The M protein has been postulated to be a major group A Streptococcal (GAS) virulence factor because of its contribution to the bacterial resistance to opsonophagocytosis  .. 
+PF03855 M-factor<br>The M-factor is a pheromone produce upon nitrogen starvation.  The production of M-factor is increased by the pheromone signal. The protein undergoes post-translational modification, to remove the C-terminal signal peptide, the carboxy-terminal cysteine residue is carboxy-methylated  and S-alkylated, with a farnesyl residue  .. 
+PF05034 MAAL; <br>Methylaspartate ammonia-lyase N-terminus. Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the N-terminal region of Methylaspartate ammonia-lyase. This domain is structurally related to Pfam:PF03952  . This domain is associated with the catalytic domain Pfam:PF07476.. 
+PF03281 Mab-21 protein<br>Pfam-B_4530 (release 6.5). This family contains Mab-21 and Mab-21 like proteins.  In C. elegans these proteins are required for several aspects of embryonic development [2-3].. 
+PF01823 MAC/Perforin domain<br>The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerisation of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerises into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin.  The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (Pfam:PF01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold  . . 
+PF03523 Macrophage scavenger receptor<br>
+PF03817 Malonate transporter MadL subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03818 Malonate/sodium symporter MadM subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02545 Maf-like protein<br>Maf is a putative inhibitor of septum formation   in eukaryotes,  bacteria, and archaea.. 
+PF02792 Mago nashi protein<br>This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene  . The human homologue has been shown to interact with an RNA binding protein Swiss:Q9Y5S9  . An RNAi knockout of the C. elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination  . Mago nashi has been found to be part of the exon-exon junction complex that binds 20 nucleotides upstream of exon-exon junctions  .. 
+PF03082 Male accessory gland secretory protein<br>Pfam-B_256 (release 6.4). The accessory gland of male insects is a genital tissue that secretes many components of the ejaculatory fluid, some of which affect the female's receptivity to courtship and her rate of oviposition.  This protein is expressed exclusively in the male accessory glands of adult Drosophila melanogaster. The proteins are transferred to the female fly during copulation and are rapidly altered in the female genital tract  .. 
+PF04112 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase<br>Pfam-B_9176 (release 7.3);. NatC N(alpha)-terminal acetyltransferases contains Mak10p,  Mak31p and Mak3p subunits.  All three subunits are associated  with each other to form the active complex  .  . 
+PF04874 Mak16 protein C-terminal region<br>Pfam-B_4960 (release 7.6). The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus  .. 
+PF01274 Malate synthase<br>
+PF02330 Mitochondrial glycoprotein<br>Pfam-B_17905 (release 5.2). This mitochondrial matrix protein family contains members of the MAM33 family which bind to the globular 'heads' of C1Q.  It is thought to be involved in mitochondrial oxidative phosphorylation and in nucleus-mitochondrion interactions  .. 
+PF02157 Mannose-6-phosphate receptor<br>This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.. 
+PF01232 Mannitol_dh_N; <br>Mannitol dehydrogenase Rossmann domain. 
+PF01050 Mannose-6-phosphate isomerase<br>Pfam-B_899 (release 3.0). All of the members of this Pfam entry belong to family 2 of the mannose-6-phosphate isomerases. The type II phosphomannose isomerases are bifunctional  enzymes. This Pfam entry covers the isomerase domain.  The guanosine diphospho-D-mannose pyrophosphorylase domain is in another Pfam entry, see Pfam:PF00483.. 
+PF05007 Mannosyltransferase (PIG-M)<br>Pfam-B_5638 (release 7.6). PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilise nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates  .. 
+PF01575 MaoC_like;<br>Pfam-B_297 (release 4.0). The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase  .  The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity  . This domain is also present in the NodN nodulation protein N.. 
+PF03642 MAP domain<br>Pfam-B_1396 (release 7.0). This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein) Swiss:Q9Z4J2  . The protein has been found in a wide range of extracellular matrix proteins  .. 
+PF02991 MAP1_LC3;<br>Autophagy protein Atg8 ubiquitin like. Pfam-B_1384 (release 6.4). Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity  . Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. The yeast proteins are involved in the autophagosome, and Atg8 binds Atg19, via its N-terminus and the C-terminus of Atg19.. 
+PF00414 Neuraxin and MAP1B repeat<br>
+PF01124 FLAP;<br>This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme  catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.. 
+PF01914 UPF0056; <br>MarC family integral membrane protein. Integral membrane protein family that includes the antibiotic resistance protein MarC.  These proteins may be transporters.. 
+PF02063 MARCKS family<br>
+PF02124 Marek's disease glycoprotein A<br>
+PF01047 MarR family<br>Pfam-B_269 (release 3.0). The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR.  A large number of compounds induce transcription of the mar operon.  This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds  . The structure of MarR is known   and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.. 
+PF02064 MAS20 protein import receptor<br>
+PF04769 Mating-type protein MAT alpha 1<br>This family includes Saccharomyces cerevisiae mating type protein alpha 1 (Swiss:P01365).  Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes.\.     MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes  .\. Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (Pfam:PF04648) response pathway  .. 
+PF01554 UPF0013; <br>Pfam-B_163 (release 4.0). 
+PF01824 MatK/TrnK amino terminal region<br>Pfam-B_30 (release 4.2). The function of this region is unknown.. 
+PF00661 Viral matrix protein<br>Pfam-B_128 (release 2.1). Found in Morbillivirus and paramyxovirus, pneumovirus.. 
+PF03819 MazG nucleotide pyrophosphohydrolase domain<br>
+PF04837 MbeB-like, N-term conserved region<br>Pfam-B_3854 (release 7.6). This family represents an N-terminal conserved region of MbeB/MobB proteins. These proteins are essential for specific plasmid transfer.. 
+PF04899 MbeD/MobD like <br>Pfam-B_5673 (release 7.6). The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilisation and transfer in the presence of conjugative plasmids  .. 
+PF03621 MbtH-like protein<br>Yeats C, Eberhardt R. This domain is found in the MbtH protein Swiss:O05821 as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologues were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al  . This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues  .  The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape  . MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids [3-6].. 
+PF02289 Cyclohydrolase (MCH)<br>Pfam-B_6511 (release 5.2). Methenyl tetrahydromethanopterin cyclohydrolase EC:3.5.4.27 is involved in methanogenesis in bacteria and archaea, producing methane from  carbon monoxide or carbon dioxide.. 
+PF00493 MCM2/3/5 family<br>
+PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain<br>Blast MCP1_ECOLI/361-421. This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.. 
+PF02993 Minor capsid protein VI<br>Pfam-B_1634 (release 6.4). This minor capsid protein may act as a link between the external capsid and the internal DNA-protein core.\.     The C-terminal 11 residues may function as a protease cofactor leading to enzyme activation  .. 
+PF02249 Methyl-coenzyme M reductase alpha subunit, C-terminal domain<br>Pfam-B_2706 (release 5.2). Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites  . The C-terminal domain is comprised of an all-alpha multi-helical bundle.. 
+PF02745 Methyl-coenzyme M reductase alpha subunit, N-terminal domain<br>Pfam-B_2706 (release 5.2). Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites  . The N-terminal domain has a ferredoxin-like fold.. 
+PF02241 Methyl-coenzyme M reductase beta subunit, C-terminal domain<br>Pfam-B_2692 (release 5.2). Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites  . The C-terminal domain of MCR beta has an all-alpha fold with buried central helix.. 
+PF02783 Methyl-coenzyme M reductase beta subunit, N-terminal domain<br>Pfam-B_2692 (release 5.2). Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites  . The N-terminal domain has an alpha/beta ferredoxin-like fold.. 
+PF02505 Methyl-coenzyme M reductase operon protein D<br>Pfam-B_2115 (release 5.4). Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha  (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240)  . Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D  . The function of proteins C and D (this  family) is unknown.. 
+PF02240 Methyl-coenzyme M reductase gamma subunit<br>Pfam-B_2713 (release 5.2). Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family)  subunits with two identical nickel porphinoid active sites  .. 
+PF02315 Methanol dehydrogenase beta subunit<br>Pfam-B_12628 (release 5.2). Methanol dehydrogenase (MDH) is a bacterial periplasmic quinoprotein that oxidises methanol to formaldehyde. MDH is a tetramer of two alpha and two beta subunits. This family contains the small beta subunit.. 
+PF04349 Periplasmic glucan biosynthesis protein, MdoG<br>This family represents MdoG, a protein that is necessary for the synthesis of periplasmic glucans. The function of MdoG remains unknown. It has been suggested that it may catalyse the addition of branches to a linear glucan backbone.. 
+PF02975 Me-amine-deh_L; <br>Methylamine dehydrogenase, L chain. 
+PF04934 MED6; <br>MED6 mediator sub complex component. Pfam-B_4045 (release 7.6). Component of RNA polymerase II holoenzyme and mediator sub complex.. 
+PF03525 Meiotic recombination protein rec114<br>
+PF03243 Alkylmercury lyase<br>Pfam-B_3505 (release 6.5). Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate.. 
+PF02065 Melibiase<br>Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K  . This family includes enzymes from GH36A-B and GH36D-K and from GH27.. 
+PF01372 Melittin<br>
+PF02964 Methane monooxygenase, hydrolase gamma chain<br>
+PF03203 MerC mercury resistance protein<br>Pfam-B_2720 (release 6.5). 
+PF05052 MerE protein<br>Pfam-B_5840 (release 7.7). The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2]. . 
+PF00376 merR; <br>MerR family regulatory protein. Prosite & Pfam-B_3021 (Release 7.5). 
+PF02411 MerT mercuric transport protein<br>Pfam-B_1796 (release 5.4). MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic  MerP (also part of the transport system) to mercuric reductase (MerE).. 
+PF02475 Met-10+ like-protein<br>Pfam-B_2239 (release 5.4). The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast (Swiss:P38793) suggesting this protein may be involved in methionine biosynthesis, transport and/or utilisation  .. 
+PF02965 Vitamin B12 dependent methionine synthase, activation domain<br>Griffiths-Jones SR, Eberhardt R. 
+PF03724 DUF306;<br>Small domain family found in proteins of of unknown function. Some are secreted (e.g. Swiss:O25998) and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene.  Over-expression in L.amazonensis increases virulence (Swiss:O43987;  ). A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.. 
+PF01676 Metalloenzyme superfamily<br>Pfam-B_1926 (release 4.1). This family includes phosphopentomutase Swiss:P07651 and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, Swiss:P37689. This family is also related to Pfam:PF00245  . The alignment contains the most conserved residues that are probably involved in metal binding and catalysis.. 
+PF02066 Metallothionein family 11<br>
+PF01439 Metallothionein<br>Prodom_1611 (release 99.1). Members of this family are metallothioneins. These proteins are cysteine rich proteins that bind to heavy metals. Members of this family appear to be closest to Class II metallothioneins, seed Pfam:PF00131.. 
+PF02067 Metallothionein family 5<br>
+PF02068 Plant PEC family metallothionein<br>
+PF02069 Prokaryotic metallothionein<br>
+PF00131 metalthio; <br>
+PF01717 Methionine_synt; <br>Cobalamin-independent synthase, Catalytic domain. Pfam-B_1909 (release 4.1). This is a family of vitamin-B12 independent methionine synthases or 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferases, EC:2.1.1.14 from bacteria and plants. Plants are the only higher eukaryotes that have the required enzymes for methionine synthesis  . This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to homocysteine  . The aligned region makes up the carboxy region of the approximately 750 amino acid protein except in some hypothetical archaeal proteins present in the family, where this region corresponds to the entire length. This domain contains the catalytic residues of the enzyme  .. 
+PF01035 Methlytrans; Methyltrans; Methyltransf_1; <br>6-O-methylguanine DNA methyltransferase, DNA binding domain. Pfam-B_1191 (release 3.0). This domain is a 3 helical bundle.. 
+PF02870 Methlytrans; Methyltrans; <br>6-O-methylguanine DNA methyltransferase, ribonuclease-like domain. Pfam-B_1191 (release 3.0). 
+PF00891 Methyltransf;<br>Pfam-B_152 (release 3.0). This family includes a range of O-methyltransferases. These enzymes utilise S-adenosyl methionine.. 
+PF01596 O-methyltransferase<br>Pfam-B_749 (release 4.1). Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase Swiss:P21964, caffeoyl-CoA O-methyltransferase Swiss:Q43095 and a family of bacterial O-methyltransferases that may be involved in antibiotic production  .. 
+PF02390 Putative methyltransferase <br>Pfam-B_1023 (release 5.2). This is a family of putative methyltransferases. The aligned  region contains the GXGXG S-AdoMet binding site suggesting  a putative methyltransferase activity.. 
+PF03737 Demethylmenaquinone methyltransferase<br>Members of this family are demethylmenaquinone methyltransferases that convert dimethylmenaquinone (DMK) to menaquinone (MK) in the final step of menaquinone biosynthesis. This region is also found at the C-terminus of the DlpA protein Swiss:Q48806.. 
+PF03492 Methytransf_6;<br>SAM dependent carboxyl methyltransferase. Pfam-B_1148 (release 7.0). This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-Methylxanthine. Caffeine is synthesised through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N.  The protein 7-methylxanthine methyltransferase (designated as CaMXMT) catalyses the second step to produce theobromine  .. 
+PF02086 D12 class N6 adenine-specific DNA methyltransferase<br>
+PF01340 Met Apo-repressor, MetJ<br>
+PF04648 Yeast mating factor alpha hormone<br>The hormone is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It inhibits DNA synthesis in type A cells synchronising them with type alpha, and so mediates the conjugation process.. 
+PF04202 Foot protein 3<br>Pfam-B_1860 (release 7.3). Mytilus foot protein-3 (Mfp-3) is a highly polymorphic protein family located in the byssal adhesive plaques of blue mussels.. 
+PF01078 Magnesium chelatase, subunit ChlI<br>Pfam-B_616 (release 3.0). Magnesium-chelatase is a three-component enzyme that  catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of  (bacterio)chlorophyll.  Due to this, it is thought that  Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.. 
+PF05043 Mga helix-turn-helix domain<br>Pfam-B_5126 (release 7.7). M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions  . This domain is found in the centre of the Mga proteins.  This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci.  These proteins have been shown to regulate the expression of important bacterial adhesins  . This is presumably a DNA-binding domain.. 
+PF05220 MgpC protein precursor<br>Pfam-B_6685 (release 7.7). This family contains several Mycoplasma MgpC like-proteins.. 
+PF02308 MgtC family<br>The MgtC protein is found in an operon with the Mg2+ transporter protein MgtB.  The function of MgtC and its homologues is not known.. 
+PF03448 MgtE intracellular N domain<br>This domain is found at the N-terminus of eubacterial magnesium transporters of the MgtE family Pfam:PF01769. This domain is an intracellular domain that has an alpha-helical structure. The crystal structure of the MgtE transporter   shows two of 5 magnesium ions are in the interface between the N domain and the CBS domains. In the absence of magnesium there is a large shift between the N and CBS domains.. 
+PF03165 MH1 domain<br>Pfam-B_519 (release 3.0). The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however.  Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [1,3].. 
+PF03166 MH2 domain<br>Pfam-B_519 (release 3.0). This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2 [1-3].. 
+PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2<br>
+PF03707 SPNTR; <br>Bacterial signalling protein N terminal repeat. Found as an N terminal triplet tandem repeat in bacterial signalling proteins. Family includes CoxC (Swiss:Q9KX27) and CoxH (Swiss:Q9KX23) from P.carboxydovorans. Each repeat contains two transmembrane helices. Domain is also described as the MHYT domain  .. 
+PF02426 Muconolactone delta-isomerase<br>Pfam-B_2784 (release 5.4). This small enzyme forms a homodecameric complex, that catalyses the third step in the catabolism of catechol to succinate- and acetyl-coa in the beta-ketoadipate pathway EC:5.3.3.4. The protein has a ferredoxin-like fold according to SCOP.. 
+PF03526 Colicin E1 (microcin) immunity protein<br>
+PF04687 Microvirus H protein (pilot protein)<br>A single molecule of H protein is found on each of the 12 spikes on the microvirus shell.  H is involved in the ejection of the phage DNA, and at  least one copy is injected into the host's periplasmic space along with the ssDNA viral genome  . Part of H is thought to lie outside the shell, where it recognises lipopolysaccharide from virus-sensitive strains  .  Part of H may lie  within the capsid, since mutations in H can influence the DNA ejection  mechanism by affecting the DNA-protein interactions  .  H may span the  capsid through the hydrophilic channels formed by G proteins  .. 
+PF04726 Microvirus J protein<br>This small protein is involved in DNA packaging, interacting with DNA via its hydrophobic carboxyl terminus.  In bacteriophage phi-X174, J is present in 60 copies, and forms an S-shaped polypeptide chain without any secondary structure.  It is thought to interact with DNA through simple charge interactions  .. 
+PF04517 Microvirus lysis protein (E), C terminus<br>E protein causes host cell lysis by inhibiting MraY, a peptidoglycan biosynthesis enzyme.  This leads to cell wall failure at septation  . The N terminal transmembrane region matches the signal peptide model and must be omitted from the family.. 
+PF04478 Mid2 like cell wall stress sensor<br>This family represents a region near the C terminus of Mid2, which contains a transmembrane region. The remainder of the protein sequence is serine-rich and of low complexity, and is therefore impossible to align accurately. Mid2 is thought to act as a mechanosensor of cell wall stress.  The C-terminal cytoplasmic region of Mid2 is known to interact with Rom2, a guanine nucleotide exchange factor (GEF) for Rho1, which is part of the cell wall integrity signalling pathway []1.. 
+PF01187 Macrophage migration inhibitory factor (MIF)<br>
+PF03775 MinC;<br>Septum formation inhibitor MinC, C-terminal domain. In Escherichia coli Swiss:P06138 assembles into a Z ring at midcell while assembly at polar sites is prevented by the min system. MinC Swiss:P18196 a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with MinDE. MinC is an oligomer, probably a dimer  . The C terminal half of MinC is the most conserved and interacts with MinD.  The N terminal half is thought interact with FtsZ.. 
+PF05209 Septum formation inhibitor MinC, N-terminal domain<br>In Escherichia coli Swiss:P06138 assembles into a Z ring at midcell while assembly at polar sites is prevented by the min system. MinC Swiss:P18196 a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with MinDE. MinC is an oligomer, probably a dimer  . The C terminal half of MinC is the most conserved and interacts with MinD.  The N terminal half is thought to interact with FtsZ.. 
+PF03776 Septum formation topological specificity factor MinE<br>The E. coli minicell locus was shown to code for three gene products (MinC, MinD, and MinE) whose coordinate action is required for proper placement of the division septum. The minE gene codes for a topological specificity factor that, in wild-type cells, prevents the division inhibitor from acting at internal division sites while permitting it to block septation at polar sites  .. 
+PF00230 Major intrinsic protein<br>MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators  .. 
+PF03094 Mlo family<br>Pfam-B_2483 (release 6.4). A family of plant integral membrane proteins, first discovered in barley. Mutants lacking wild-type Mlo proteins show broad spectrum resistance to the powdery mildew fungus, and dysregulated cell death control, with spontaneous cell death in response to developmental or abiotic stimuli. Thus wild-type Mlo proteins are thought to be inhibitors of cell death whose deficiency lowers the threshold required to trigger the cascade of events that result in plant cell death. Mlo proteins are localised in the plasma membrane and possess seven transmembrane regions; thus the Mlo family is the only major higher plant family to possess 7 transmembrane domains. It has been suggested that Mlo proteins function as G-protein coupled receptors in plants  ; however the molecular and biological functions of Mlo proteins remain to be fully determined.. 
+PF03304 Lipoprotein_12; <br>Mlp lipoprotein family. Pfam-B_1663 (release 6.5). The Mlp (for Multicopy Lipoprotein) family of lipoproteins is found in Borrelia species  . This family were previously known as 2.9 lipoprotein genes  . These surface expressed genes may represent new candidate vaccinogens for Lyme disease  . Members of this family generally are downstream of four ORFs called A,B,C and D that are involved in hemolytic activity. . 
+PF03562 MltA specific insert domain<br>Pfam-B_1127 (release 7.0). This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme  . This domain may be involved in peptidoglycan binding.. 
+PF01642 Methylmalonyl-CoA mutase<br>Pfam-B_1611 (release 4.1). The enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA  .. 
+PF03972 MmgE/PrpD family<br>This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle.. 
+PF02406 MmoB/DmpM family <br>Pfam-B_1148 (release 5.2). This family consists of monooxygenase components such as MmoB methane monooxygenase (EC:1.14.13.25) regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen  . Also found in this family is DmpM or Phenol hydroxylase (EC:1.14.13.7) protein component P2, this protein lacks redox co-factors and is required for optimal turnover of Phenol hydroxylase  .. 
+PF03176 MMPL family<br>Pfam-B_357 (release 6.5). Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport  .. 
+PF01926 50S ribosome-binding GTPase<br>The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.. 
+PF01054 Mouse mammary tumour virus superantigen<br>Pfam-B_518 (release 3.0). The mouse mammary tumour virus (MMTV) is a milk-transmitted type B retrovirus.  The  superantigen (SAg) is encoded by the long  terminal repeat. The SAgs are also called PR73.. 
+PF05067 Manganese containing catalase<br>Catalases are important antioxidant metalloenzymes that catalyse disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese  .. 
+PF03962 Mnd1 family<br>This family of proteins includes  MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair  .. 
+PF04039 Domain related to MnhB subunit of Na+/H+ antiporter<br>Possible subunit of Na+/H+ antiporter  ,  . Predicted integral membrane protein, usually four transmembrane regions in this domain.  Often found in bacterial NADH dehydrogenase subunit.. 
+PF01899 DUF68; <br>Na+/H+ ion antiporter subunit. Subunit of a Na+/H+ Prokaryotic antiporter complex ( , ).. 
+PF03404 Mo-co oxidoreductase dimerisation domain<br>This domain is found in molybdopterin cofactor (Mo-co) oxidoreductases.  It is involved in dimer formation, and has an Ig-fold structure  .. 
+PF01967 MoaC family<br>Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.. 
+PF02391 MoeA; MoeE;<br>Pfam-B_1056 (release 5.2). This family contains the MoaE protein that is involved in biosynthesis of molybdopterin  . Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.. 
+PF01076 Plasmid recombination enzyme<br>Pfam-B_717 (release 3.0). With some plasmids, recombination can occur in a site specific  manner that is independent of RecA.  In such cases, the  recombination event requires another protein called Pre. Pre is a plasmid recombination enzyme.  This protein is  also known as Mob (conjugative mobilisation).. 
+PF03389 MobA/MobL family<br>Pfam-B_3424 (release 6.6). This family includes of the MobA protein from the E. coli plasmid RSF1010, and the MobL protein from the Thiobacillus ferrooxidans plasmid PTF1. These sequences are mobilisation proteins, which are essential for specific plasmid transfer.. 
+PF03205 Molybdopterin guanine dinucleotide synthesis protein B<br>Pfam-B_2446 (release 6.5). This protein contains a P-loop.. 
+PF04698 MOBP; MOBP_C-Myrip;<br>Rab effector MyRIP/melanophilin C-terminus. Pfam-B_4174 (release 7.5). This domain is found at the C-terminus of the Rab effector proteins MyRIP and melanophilin.. 
+PF05161 MOFRL family<br>MOFRL(multi-organism fragment with rich Leucine) family exists in bacteria and eukaryotes. The function of this domain is not clear, although it  exists in some putative enzymes such as reductases and kinases.. 
+PF04603 Ran-interacting Mog1 protein<br>Pfam-B_4771 (release 7.5). Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homologue of Mog1 is thought to be alternatively spliced [1,2,3,4].  . 
+PF04879 Molybdopterin oxidoreductase Fe4S4 domain<br>This domain is found in formate dehydrogenase H for which the structure is known. The first domain (residues 1 to 60, 448 to 476, and 499 to 540), comprising two small antiparallel sheets and four helices, coordinates the Fe4S4 cluster just below the protein surface  .. 
+PF00384 molybdopterin; <br>Molybdopterin oxidoreductase. Prosite & Pfam-B_2803 (Release 7.5). 
+PF01568 Molydopterin dinucleotide binding domain<br>Pfam-B_129 (release 4.0). This domain is found in various molybdopterin - containing  oxidoreductases and tungsten formylmethanofuran dehydrogenase  subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase  subunit (FmdD); where the domain constitutes almost the entire subunit. The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a  molybdopterin dinucleotide cofactor  . This domain corresponds to the C-terminal domain IV in dimethyl sulfoxide (DMSO)reductase which interacts with the 2-amino pyrimidone ring of both  molybdopterin guanine dinucleotide molecules  .. 
+PF04744 Monooxygenase subunit B protein<br>Pfam-B_6020 (release 7.5). Family of membrane associated monooxygenases (EC 1.13.12.-) which utilise O(2) to oxidise their substrate.  Family members include both ammonia and methane monooxygenases involved in the oxidation of their respective substrates.  These enzymes are multi-subunit  complexes.  This family represents the B subunit of the enzyme; the A subunit is thought to contain the active site. [1,2]. . 
+PF03473 MOSC domain<br>Aravind L, Anantharaman V. The MOSC (MOCO sulfurase C-terminal) domain is a  superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.. 
+PF02722 Major Outer Sheath Protein C-terminal region<br>Pfam-B_653 (release 5.5). This is a family of spirochete major outer sheath protein C-terminal  regions. These proteins are present on the bacterial cell surface.  In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and  fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola  .. 
+PF02707 MOSP; <br>Major Outer Sheath Protein N-terminal region. Pfam-B_653 (release 5.5). This is a family of spirochete major outer sheath protein N-terminal regions. These proteins are present on the bacterial cell surface.  In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and  fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola  .. 
+PF01618 MotA/TolQ/ExbB proton channel family<br>Pfam-B_1099 (release 4.1). This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels.  MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller  . ExbB is part of the TonB-dependent transduction complex.  The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.. 
+PF04006 Mpp10 protein<br>Pfam-B_12513 (release 7.3). This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites  .. 
+PF05172 MPPN;<br>Nup53/35/40-type RNA recognition motif. Members of this family belong to the nucleor pore complex, NPC, the only gateway between the nucleus and the cytoplasm. The NPC consists of several subcomplexes each one of which is made up of multiple copies of several individual Nup, Nic or Sec protein subunits. In yeast, this Nup or nucleoporin subunit is numbered Nup53, Nup40 in Schizo. pombe and in vertebrates as Nup35. This subunit forms part of the inner ring within the membrane and interacts directly with Nup-Ndc1, considered to be an anchor for the NPC in the pore membrane  . This region of the Nup is the RNA-recognition region  .. 
+PF01188 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain<br>C-terminal domain is TIM barrel fold, dehydratase-like domain. Manganese is associated with this domain.. 
+PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain<br>SCOP reports fold similarity with enolase N-terminal domain.. 
+PF04152 Mer11_DNA_bind; <br>Mre11 DNA-binding presumed domain . Pfam-B_3909 (release 7.3);. The Mre11 complex is a multi-subunit nuclease that is composed  of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication  .  Mre11 has an intrinsic DNA-binding activity that is stimulated  by Rad50 on its own or in combination with Nbs1  .. 
+PF04085 rod shape-determining protein MreC<br>TIGRFAMs (release 2.0);. MreC (murein formation C) is involved in the rod shape  determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.. 
+PF04093 rod shape-determining protein MreD<br>MreD (murein formation D) is involved in the rod shape  determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.. 
+PF03919 mRNA capping enzyme, C-terminal domain<br>
+PF01331 mRNA capping enzyme, catalytic domain<br>This family represents the ATP binding catalytic domain of the mRNA capping enzyme.. 
+PF02940 mRNA capping enzyme, beta chain<br>The beta chain of mRNA capping enzyme has triphosphatase activity.  The function of the capping enzyme also depends on the guanylyltransferase activity conferred by the alpha chain (see Pfam:PF01331). 
+PF02349 Major surface glycoprotein<br>Pfam-B_864 (release 5.2). This is a novel repeat in Pneumocystis carinii Major surface glycoprotein (MSG) some members of the alignment have up to nine  repeats of this family, the repeats containing several conserved  cysteines.  The MSG of P. carinii is an important protein in  host-pathogen interactions  . Surface glycoprotein A Swiss:O59920 from Pneumocystis carinii is a main target for the host immune system, this protein  is implicated in the attachment of Pneumocystis carinii to the host alveolar epithelial cells, alveolar macrophages,  host surfactant and possibly accounts in part for the hypoxia seen in Pneumocystis carinii pneumonia (PCP)  .. 
+PF04066 Multiple resistance and pH regulation protein F (MrpF / PhaF)<br>Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation.\.       It is also involved in symbiosis in Rhizobium meliloti  .  MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis.  MrpF is thought to be an efflux system for Na+ and cholate  . The Mrp system in Bacilli may also have primary energisation capacities  .. 
+PF04471 Restriction endonuclease<br>Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2].. 
+PF00924 UPF0003;<br>Mechanosensitive ion channel. Pfam-B_1136 (release 3.0). Two members of  this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterised. Both proteins form mechanosensitive (MS) ion channels upon  reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.. 
+PF00985 Merozoite Surface Antigen 2 (MSA-2) family<br>Pfam-B_1052 (release 3.0). 
+PF01741 Large-conductance mechanosensitive channel, MscL<br>
+PF01716 Manganese-stabilising protein / photosystem II polypeptide<br>Pfam-B_1814 (release 4.1). This family consists of the 33 KDa photosystem II polypeptide from the oxygen evolving complex (OEC) of plants and cyanobacteria. The protein is also known as the manganese-stabilising protein as it is associated with the manganese complex of the OEC and may provide the ligands for the complex  .. 
+PF03429 Major surface protein 1B<br>Pfam-B_4414 (release 6.6). The major surface protein (MSP1) of the cattle pathogen Anaplasma is a heterodimer comprised of MSP1a and MSP1b.  This family is the MSP1b chain.  There MSP1 proteins are putative adhesins for bovine erythrocytes. . 
+PF04421 Mss4 protein<br>
+PF03940 Male specific sperm protein<br>This family of drosophila proteins are typified by the repetitive motif C-G-P.. 
+PF05063 MT-A70 <br>Pfam-B_3025 (release 7.7). MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A  methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs. . 
+PF01993 methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase<br>This enzyme family is involved in formation of methane from carbon dioxide EC:1.5.99.9. The enzyme requires coenzyme F420  .. 
+PF02536 mTERF<br>Pfam-B_1422 (release 5.4). This family contains one sequence of known function  Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer  .  The leucine zippers are not implicated in a dimerisation role as in other leucine zippers  .. 
+PF02219 Methylenetetrahydrofolate reductase<br>Pfam-B_2407 (release 5.2). This family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and  methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known   to be a TIM barrel.. 
+PF05068 Mannitol repressor<br>The mannitol operon of Escherichia coli, encoding the mannitol-specific enzyme II of the phosphotransferase system (MtlA) and mannitol phosphate dehydrogenase (MtlD) contains an additional downstream open reading frame which encodes the mannitol repressor (MtlR).. 
+PF03083 Sugar efflux transporter for intercellular exchange<br>Pfam-B_623 (release 6.4). This family includes proteins such as drosophila saliva  , MtN3 involved in root nodule development   and a protein involved in activation and expression of recombination activation genes (RAGs)  . Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter  .. 
+PF03821 Golgi 4-transmembrane spanning transporter<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04208 Tetrahydromethanopterin S-methyltransferase, subunit A <br>TIGRFAMs (release 2.0);. The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump  .. 
+PF04211 Tetrahydromethanopterin S-methyltransferase, subunit C <br>TIGRFAMs (release 2.0);. The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump  .. 
+PF04207 Tetrahydromethanopterin S-methyltransferase, subunit D <br>TIGRFAMs (release 2.0);. The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump  .. 
+PF04206 Tetrahydromethanopterin S-methyltransferase, subunit E <br>TIGRFAMs (release 2.0);. The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump  . . 
+PF04210 Tetrahydromethanopterin S-methyltransferase, subunit G <br>TIGRFAMs (release 2.0);. The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump  .. 
+PF02007 Tetrahydromethanopterin S-methyltransferase MtrH subunit<br>The enzyme tetrahydromethanopterin S-methyltransferase EC:2.1.1.86 is composed of eight subunits  . The enzyme is a membrane- associated enzyme complex which catalyses an energy-conserving, sodium-ion-translocating step in methanogenesis from hydrogen and carbon dioxide  . . 
+PF05175 Methyltransferase small domain<br>This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other  methyltransferases (eg Swiss:Q53742).. 
+PF02416 mttA/Hcf106 family<br>Pfam-B_1826 (release 5.4). Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts  . Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif  .. 
+PF02316 Mu_DNA_bind;<br>Mu DNA-binding domain. Pfam-B_12856 (release 5.2). This family consists of MuA-transposase and repressor protein CI. These proteins contain homologous DNA-binding domains at their N-termini which compete for the same DNA site within the Mu bacteriophage genome.. 
+PF02914 Mu_transposase;<br>Bacteriophage Mu transposase. 
+PF03888 MucB_ResB; <br>Members of this family are regulators of the anti-sigma E protein  RseD.. 
+PF03108 MuDR;<br>MuDR family transposase. Pfam-B_271 (release 6.5). This region is found in plant proteins that are presumed to be the transposases for Mutator transposable elements [1,2]. These transposons contain two ORFs. The molecular function of this region is unknown.. 
+PF04310 MukB N-terminal<br>This family represents the N-terminal region of MukB, one of a group of bacterial proteins essential for the movement of nucleoids from mid-cell towards the cell quarters (i.e. chromosome partitioning).  The structure of the N-terminal domain consists of an antiparallel six-stranded beta sheet surrounded by one helix on one side and by five helices on the other side  . It contains an exposed Walker A loop in an unexpected helix-loop-helix motif (in other proteins, Walker A motifs generally adopt a P loop conformation as part of a strand-loop-helix motif embedded in a conserved topology of alternating helices and (parallel) beta strands) .. 
+PF04288 MukE-like family<br>Bacterial protein involved in chromosome partitioning, MukE. 
+PF00893 DUF7; SMR;<br>Small Multidrug Resistance protein. Pfam-B_1082 (release 3.0). This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide (  and quaternary ammonium compounds  , through coupling with proton influx  .. 
+PF01225 FPGS; <br>Mur ligase family, catalytic domain. This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188),  MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan.  Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide.  The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine.  The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.. 
+PF02875 FPGS; <br>Mur ligase family, glutamate ligase domain. This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188),  MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan.  Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide.  The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine.  The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.. 
+PF02873 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain<br>Pfam-B_1092 (release 5.2). Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.. 
+PF02976 DNA mismatch repair enzyme MutH<br>
+PF01624 MutS;MutS_N;<br>Pfam-B_800 (release 4.1). This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein  . The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in  .. 
+PF05188 MutS domain II<br>Pfam-B_800 (release 4.1). This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein  .  This domain corresponds to domain II in Thermus aquaticus MutS as characterised in  , and has similarity resembles RNAse-H-like domains (see Pfam:PF00075).. 
+PF05192 MutS domain III<br>This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein  . The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterised in  .   . 
+PF05190 MutS family domain IV<br>This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein  . The aligned region corresponds in part with globular domain IV,  which is involved in DNA binding, in Thermus aquaticus MutS as characterised in  .. 
+PF00488 mutS;MutS_C;<br>This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein  . The aligned region corresponds with domain V of  Thermus aquaticus MutS as characterised in  , which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.. 
+PF03023 MviN-like protein<br>Pfam-B_1348 (release 6.4). Deletion of the mviN virulence gene in Salmonella enterica serovar. Typhimurium greatly reduces virulence in a mouse model of typhoid-like disease  . Open reading frames encoding homologues of MviN have since been identified in a variety of bacteria  , including pathogens and non-pathogens and plant-symbionts.  In the nitrogen-fixing symbiont Rhizobium tropici, mviN is required for motility. The MviM protein is predicted to be membrane-associated.. 
+PF02344 Myc leucine zipper domain<br>Pfam-B_829 (release 5.2). This family consists of the leucine zipper dimerisation domain found in both cellular c-Myc proto-oncogenes and viral v-Myc oncogenes.  Dimerisation via the leucine zipper motif with other basic helix-loop-helix-leucine zipper (b/HLH/lz) proteins such as  Max Swiss:P25912 is required for efficient DNA binding.  The Myc-Max dimer is a transactivating complex activating expression of growth related genes promoting cell proliferation. The dimerisation is facilitated via interdigitating leucine residues  every 7th position of the alpha helix.  Like charge repulsion of  adjacent residues in this region perturbs the formation of homodimers  with heterodimers being promoted by opposing charge attractions.. 
+PF01056 Myc_N_term; <br>Myc amino-terminal region. Pfam-B_387 (release 3.0). The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see Pfam:PF00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication  . Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest  .. 
+PF01669 Myelin basic protein<br>Pfam-B_1868 (release 4.1). 
+PF01275 Myelin proteolipid protein (PLP or lipophilin)<br>
+PF00063 myosin_head; <br>Myosin head (motor domain). Blastp MYSA_HUMAN/1-840. 
+PF01576 Myosin_tail; <br>Pfam-B_356 (release 4.1). The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types  . This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then  assemble into the macromolecular thick filament  . The coiled-coil region provides the structural backbone the thick filament  . . 
+PF00819 Myotoxin<br>Pfam-B_1337 (release 2.1). 
+PF02384 N-6 DNA Methylase<br>Pfam-B_508 (release 5.2). Restriction-modification (R-M) systems protect a bacterial  cell against invasion of foreign DNA by endonucleolytic  cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (Pfam:PF01420), and R  . This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.. 
+PF01555 DNA methylase<br>Pfam-B_164 (release 4.0). Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.. 
+PF04245 37-kD nucleoid-associated bacterial protein<br>
+PF01235 Sodium:alanine symporter family<br>
+PF03390 Na_citrate; <br>2-hydroxycarboxylate transporter family. Pfam-B_3683 (release 6.6). The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate  .. 
+PF03553 Na+/H+ antiporter family<br>Pfam-B_620 (release 7.0). This family includes integral membrane proteins, some of which are NA+/H+ antiporters  .. 
+PF00287 Sodium / potassium ATPase beta chain<br>
+PF00939 Sodium:sulfate symporter transmembrane region<br>Pfam-B_1100 (release 3.0). There are also some members in this family that do not match the Prosite motif, and belong to the subfamily  SODIT1.. 
+PF04902 Conserved region in Nab1<br>Pfam-B_6188 (release 7.6). Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors  . This C-terminal region is found only in the Nab1 subfamily.. 
+PF01849 NAC domain<br>
+PF00175 oxidored_fad; NAD_binding; <br>Oxidoreductase NAD-binding domain . Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.. 
+PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase<br>The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.. 
+PF03447 Homoserine dehydrogenase, NAD binding domain<br>Pfam-B_459 (release 2.1). This domain adopts a Rossmann NAD binding fold.  The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.. 
+PF01210 NAD_Gly3P_dh; <br>NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus. NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain  .. 
+PF01513 DUF15; <br>Pfam-B_797 (release 4.0). Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.. 
+PF02540 NAD synthase<br>NAD synthase (EC:6.3.5.1) is involved in the de novo synthesis of NAD and is induced by stress factors such as heat shock and glucose limitation.. 
+PF00146 NADH dehydrogenase<br>
+PF02477 Nairo_nucleocap; <br>Nucleocapsid N protein. Pfam-B_2892 (release 5.4). The nucleoprotein of the ssRNA negative-strand Nairovirus is an internal part of the virus particle. . 
+PF04131 nanE; <br>Putative N-acetylmannosamine-6-phosphate epimerase. This family represents a putative ManNAc-6-P-to-GlcNAc-6P epimerase in the N-acetylmannosamine (ManNAc) utilisation pathway found mainly in pathogenic bacteria.. 
+PF04660 Nanovirus coat protein<br>Pfam-B_4486 (release 7.5). Family of conserved Nanoviral coat proteins  .. 
+PF00956 NAP_family; <br>Nucleosome assembly protein (NAP). Pfam-B_1009 (release 3.0). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity.  They affect the transcription of many genes.. 
+PF03892 Nitrate reductase cytochrome c-type subunit (NapB)<br>The napB gene encodes a dihaem cytochrome c, the small subunit of a heterodimeric periplasmic nitrate reductase  .. 
+PF03927 NapD protein<br>Uncharacterized protein involved in formation of periplasmic nitrate reductase.. 
+PF03059 Nicotianamine synthase protein<br>Pfam-B_2173 (release 6.4). Nicotianamine synthase EC:2.5.1.43 catalyses the trimerisation of S-adenosylmethionine to yield one molecule of nicotianamine. Nicotianamine has an important role in plant iron uptake mechanisms.  Plants adopt two strategies (termed I and II) of iron acquisition.  Strategy I is adopted by all higher plants except graminaceous plants, which adopt strategy II [1,2]. In strategy I plants, the role of nicotianamine is not fully determined: possible roles include the formation of more stable complexes with ferrous than with ferric ion, which might serve as a sensor of the physiological status of iron within a plant, or which might be involved in the transport of iron  . In strategy II (graminaceous) plants, nicotianamine is the key intermediate (and nicotianamine synthase the key enzyme) in the synthesis of the mugineic family (the only known family in plants) of phytosiderophores. Phytosiderophores are iron chelators whose secretion by the roots is greatly increased in instances of iron deficiency  . The 3D structures of five example NAS from Methanothermobacter thermautotrophicus reveal the monomer to consist of a five-helical bundle N-terminal domain on top of a classic Rossmann fold C-terminal domain. The N-terminal domain is unique to the NAS family, whereas the C-terminal domain is homologous to the class I family of SAM-dependent methyltransferases. An active site is created at the interface of the two domains, at the rim of a large cavity that corresponds to the nucleotide binding site such as is found in other proteins adopting a Rossmann fold  .. 
+PF04159 NB glycoprotein<br>Pfam-B_1501 (release 7.3). The NB glycoprotein is found in Influenza type B virus.  Its function is unknown.. 
+PF00931 NB-ARC domain<br>
+PF04485 nblA; <br>Phycobilisome degradation protein nblA . In the cyanobacterium Synechococcus PCC 7942 (Swiss:P35087) , nblA triggers degradation of light-harvesting phycobiliproteins in response to  deprivation nutrients including nitrogen, phosphorus and sulphur.  The  mechanism of nblA function is not known, but it has been hypothesised that nblA may act by disrupting phycobilisome structure, activating a protease or tagging phycobiliproteins for proteolysis. Members of this family have also been identified in the chloroplasts of some red algae.. 
+PF03801 HEC/Ndc80p family<br>Members of this family are components of the mitotic spindle.  It has been shown that Ndc80/HEC from yeast is part of a complex called the Ndc80p complex  . This complex is thought to bind to the microtubules of the spindle.. 
+PF00334 Nucleoside diphosphate kinase<br>
+PF05031 Iron Transport-associated domain <br>This domain is involved in the transport of iron, possibly as a siderophore.. 
+PF00880 Nebulin_repeat; <br>Pfam-B_1603 (release 3.0). 
+PF04299 DUF449; Neg_reg; <br>Putative FMN-binding domain. In Bacillus subtilis, family member Swiss:P21341 (PAI 2/ORF-2) was found to be essential for growth  . The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.. 
+PF00960 Neocarzinostatin family<br>
+PF03391 Nepovirus coat protein, central domain<br>Pfam-B_3589 (release 6.6). The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure  .. 
+PF03688 Nepovirus coat protein, C-terminal domain<br>Pfam-B_3589 (release 6.6). The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure  .. 
+PF03689 Nepovirus coat protein, N-terminal domain<br>Pfam-B_3589 (release 6.6). The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure  .. 
+PF00064 neur; <br>Overington and HMM_iterative_training. Neuraminidases cleave sialic acid residues from glycoproteins. Belong to the sialidase family - but this alignment does not generalise to the other sialidases. Structure is a 6-sheet beta propeller.. 
+PF02932 Neurotransmitter-gated ion-channel transmembrane region<br>This family includes the four transmembrane helices that form the ion channel.. 
+PF02158 Neuregulin family<br>
+PF03823 Neurokinin B<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00243 Nerve growth factor family<br>
+PF02979 Nitrile hydratase, alpha chain<br>
+PF02211 Nitrile hydratase beta subunit<br>Pfam-B_5347 (release 5.2). Nitrile hydratases EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile hydratases are composed of two subunits, alpha and beta, and they contain one iron atom per alpha beta unit  . . 
+PF01292 Prokaryotic cytochrome b561<br>This family includes cytochrome b561 and related proteins, in addition to the nickel-dependent hydrogenases b-type cytochrome subunit.  Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a  prokaryotic family.  Members of the 'eukaryotic cytochrome b561' family can be found in Pfam: PF03188.. 
+PF04097 NIC;<br>Pfam-B_5541 (release 7.3);. Nup93/Nic96 is a component of the nuclear pore complex.  It is required for the correct assembly of the nuclear pore complex  .  In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1  . The structure of Nic96 has revealed a mostly alpha helical structure  .. 
+PF03824 High-affinity nickel-transport protein<br>High affinity nickel transporters involved in the incorporation of nickel into H2-uptake hydrogenase   and urease   enzymes. Essential for the expression of catalytically active hydrogenase and urease. Ion uptake is dependent on proton motive force.  HoxN in Alcaligenes eutrophus is thought to be an integral membrane protein with seven transmembrane helices  . The family also includes a cobalt transporter.. 
+PF00374 Nickel-dependent hydrogenase<br>
+PF04891 NifQ<br>Pfam-B_6173 (release 7.6). NifQ is involved in early stages of the biosynthesis of the iron-molybdenum cofactor (FeMo-co)  , which is an integral part of the active site of dinitrogenase  .  The conserved C-terminal cysteine residues may be  involved in metal binding  .. 
+PF01106 NifU; NifU-like; <br>Pfam-B_1206 (release 3.0). This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown  .. 
+PF01592 NifU-like N terminal domain<br>Pfam-B_772 (release 4.1). This domain is found in NifU in combination with Pfam:PF01106. This domain is found on isolated in several bacterial species such as Swiss:O53156. The nif genes are responsible for nitrogen fixation.  However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation. These proteins appear to be scaffold proteins for iron-sulfur clusters  .. 
+PF03206 Nitrogen fixation protein NifW<br>Pfam-B_2891 (release 6.5). Nitrogenase is a complex metalloenzyme composed of two proteins designated the Fe-protein and the MoFe-protein. Apart from these two proteins, a number of accessory proteins are essential for the maturation and assembly of nitrogenase. Even though experimental evidence suggests that these accessory proteins are required for nitrogenase activity, the exact roles played by many of these proteins in the functions of nitrogenase are unclear  .\.  Using yeast two-hybrid screening it has been shown that NifW can interact with itself as well as NifZ  .. 
+PF04319 NifZ domain<br>Pfam-B_6057 (release 7.3). This short protein is found in the nif (nitrogen fixation) operon.  Its function is unknown but is probably involved in nitrogen fixation or regulating some component of this process. This 75 residue region is presumed to be a domain.  It is found in isolation in some members and in the amino terminal half of the longer NifZ proteins.. 
+PF01077 Nitrite and sulphite reductase 4Fe-4S domain<br>Pfam-B_1092 (release 3.0). Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully.  They are also both important for the dissimilation of oxidised anions for energy transduction.. 
+PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain<br>Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidised anions for energy transduction  . Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain.. 
+PF02665 Nitrate reductase gamma subunit<br>This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool  .\.      It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit  .  The nitrate reductase enzyme, EC:1.7.99.4 catalyses the conversion of nitrite to nitrate via the reduction of an acceptor.  The nitrate reductase enzyme is composed of three subunits  .  Nitrate is the most widely used alternative electron acceptor after oxygen  .. 
+PF02087 Nitrophorin<br>
+PF00881 Nitroreductase family<br>Pfam-B_481 (release 3.0). The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.. 
+PF05211 Neuraminyllactose-binding hemagglutinin precursor (NLBH)<br>Pfam-B_6567 (release 7.7). This family is comprised of several flagellar sheath adhesin proteins also called neuraminyllactose-binding hemagglutinin precursor (NLBH) or N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunits. NLBH is found exclusively in Helicobacter which are gut colonising bacteria and bind to sialic acid rich macromolecules present on the gastric epithelium  .. 
+PF04170 NlpE N-terminal domain<br>This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway  . This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes  .. 
+PF04973 Nicotinamide mononucleotide transporter<br>Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide [1,2].. 
+PF01233 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain<br>The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.. 
+PF02799 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain<br>The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.. 
+PF02070 Neuromedin U<br>
+PF03980 Nnf1 <br>NNF1 is an essential yeast gene that is necessary for chromosome  segregation.  It is associated with the spindle poles   and forms  part of a kinetochore subcomplex called MIND  .. 
+PF02898 Nitric oxide synthase, oxygenase domain<br>
+PF02474 Nodulation protein A (NodA)<br>Pfam-B_2183 (release 5.4). Rhizobia nodulation (nod) genes control the biosynthesis of Nod factors required for infection and nodulation of their legume hosts. Nodulation  protein A (NodA) is a N-acetyltransferase involved in production of Nod factors that stimulate mitosis in various plant protoplasts.. 
+PF01798 Putative snoRNA binding domain<br>Pfam-B_1362 (release 4.2). This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) Swiss:Q12499 from yeast is the protein component of a ribonucleoprotein protein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex  . Nop56p Swiss:O00567 and Nop5p interact with Nop1p and are required for ribosome biogenesis  . Prp31p Swiss:p49704 is required for pre-mRNA splicing in S. cerevisiae  .. 
+PF02451 Nodulin<br>Pfam-B_2163 (release 5.4). Nodulin is a plant protein of unknown function. It is induced during nodulation in legume roots after rhizobium infection.. 
+PF01189 Nol1_Nop2_Sun;<br>NOL1/NOP2/sun family. 
+PF04135 Nucleolar RNA-binding protein, Nop10p family<br>Nop10p is a nucleolar protein that is specifically associated with  H/ACA snoRNAs.  It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA  snoRNAs (H/ACA snoRNPs).  Nop10p is probably necessary for the stability of these RNPs  .. 
+PF05048 Periplasmic copper-binding protein (NosD)<br>Pfam-B_5499 (release 7.7). NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ)  . This region forms a parallel beta helix domain.. 
+PF04054 CCR4-Not complex component, Not1<br>Pfam-B_13503 (release 7.3);. The Ccr4-Not complex is a global regulator of transcription that  affects genes positively and negatively and is thought to regulate  transcription factor TFIID  . . 
+PF00066 notch; <br>Swissprot_feature_table. The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR   and was shown to contain three disulphide bonds and coordinate a calcium ion.  Three repeats are also found in the PAPP-A peptidase  .. 
+PF03000 NPH3 family<br>Pfam-B_1584 (release 6.4). Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay  .. 
+PF03116 NQR2, RnfD, RnfE family<br>Pfam-B_2882 (release 6.5). This family of bacterial proteins includes a sodium-translocating  NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium  pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting  (by an unknown mechanism) the transcription of the transcriptional activator ToxT  . The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted  .. 
+PF01566 Natural resistance-associated macrophage protein<br>Pfam-B_624 (release 4.0). The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains  . This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis  . By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria  . Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis  . Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals  . The yeast proteins Smf1 and Smf2 may also transport divalent cations  .. 
+PF03813 Nrap protein<br>Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus  . Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript  .. 
+PF03916 Polysulphide reductase, NrfD<br>NrfD is an integral transmembrane protein with loops in both the  periplasm and the cytoplasm.  NrfD is thought to participate in  the transfer of electrons, from the quinone pool into the terminal  components of the Nrf pathway  . . 
+PF02723 Non-structural protein NS3/Small envelope protein E<br>Pfam-B_1913 (release 5.5) & Pfam-B_7381 (release 8.0). This is a family of small non-structural proteins, well conserved among Coronavirus strains. This protein is also found in murine hepatitis virus as small envelope protein E (e.g. Swiss:O72008).. 
+PF02071 Aromatic-di-Alanine (AdAR) repeat <br>This repeat is found in NSF attachment proteins. Its structure is similar to that found in TPR repeats Pfam:PF00515.. 
+PF05064 Nsp1-like C-terminal region<br>Pfam-B_3555 (release 7.7). This family probably forms a coiled-coil  .  This important region of Nsp1 is involved in binding Nup82  .. 
+PF03146 Agrin NtA domain<br>Agrin is a multidomain heparan sulphate proteoglycan, that is a key organiser for the induction of postsynaptic specialisations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino terminal (NtA) domain  . This region mediates high affinity interaction with the coiled-coil domain of laminins. The binding of agrin to laminins via the NtA domain is subject to tissue-specific regulation. The NtA domain-containing form of agrin is expressed in non-neuronal cells or in neurons that project to non-neuronal cell such as motor neurons. The structure of this domain is an OB-fold  .. 
+PF02136 Nuclear transport factor 2 (NTF2) domain<br>This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.. 
+PF00483 ADP_glu_Plase;<br>Nucleotidyl transferase. This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.. 
+PF05014 Nucleoside 2-deoxyribosyltransferase<br>Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides  .. 
+PF03825 Nucleoside H+ symporter<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02321 Outer membrane efflux protein<br>The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria.\.    Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.. 
+PF02265 Nuclease; <br>Pfam-B_2480 (release 5.2). This family contains both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity.. 
+PF03066 Nucleoplasmin<br>Pfam-B_2930 (release 6.4). Nucleoplasmins are also known as chromatin decondensation proteins.  They bind to core histones and transfer DNA to them in a reaction that requires ATP.  This is thought to play a  role in the assembly of regular nucleosomal arrays.. 
+PF03177 Nucleoporin;<br>Non-repetitive/WGA-negative nucleoporin C-terminal. Pfam-B_1212 (release 6.5). This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterised by the FG repeat Pfam:PF03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore  .. 
+PF01773 Nucleoside_tra2; <br>Na+ dependent nucleoside transporter N-terminus. This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane  . Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC  . This alignment covers the N terminus of this family. 
+PF03800 Nuf2 family<br>Members of this family are components of the mitotic spindle.  It has been shown that Nuf2 from yeast is part of a complex called the Ndc80p complex  . This complex is thought to bind to the microtubules of the spindle. An arabidopsis protein has been included in this family that has previously not been identified as a member of this family, Swiss:Q9C953. The match is not strong, but in common with other members of this family contains coiled-coil to the C terminus of this region.. 
+PF04121 Nuclear pore protein 84 / 107 <br>Pfam-B_13117 (release 7.3);. Nup84p forms a complex with five proteins, of which Nup120p,  Nup85p, Sec13p, and a Sec13p homologues. This Nup84p complex in  conjunction with Sec13-type proteins is required for correct  nuclear pore biogenesis  .. 
+PF01029 NusB family<br>The NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination. . 
+PF02357 Transcription termination factor nusG<br>Pfam-B_697 (release 5.2). 
+PF04277 Oxaloacetate decarboxylase, gamma chain <br>TIGRFAMs (release 2.0);. 
+PF03977 OadB_MmdB;<br>Na+-transporting oxaloacetate decarboxylase beta subunit. Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis  .. 
+PF04225 Opacity-associated protein A LysM-like domain<br>This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1,2]. This is a LysM-like domain.. 
+PF03373 Octapeptide repeat<br>This octapeptide repeat is found in several bacterial proteins. The function of this repeat is unknown.. 
+PF02317 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain<br>Pfam-B_9653 (release 5.2). This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.. 
+PF02101 Ocular albinism type 1 protein<br>
+PF02100 Ornithine decarboxylase antizyme<br>IPR002993 & Pfam-B_34796 (release 7.7). This family consists of ornithine decarboxylase antizyme proteins. The polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is degraded by the 26 S proteasome via a ubiquitin-independent pathway. Its degradation is greatly accelerated by association with the polyamine-induced regulatory protein antizyme 1 (AZ1)  .. 
+PF02423 ODC_Mu_crystall; <br>Ornithine cyclodeaminase/mu-crystallin family. Pfam-B_1960 (release 5.4). This family contains the bacterial Ornithine cyclodeaminase enzyme EC:4.3.1.12, which catalyses the deamination of ornithine to proline  . This family also contains mu-Crystallin the major component of the eye lens in several Australian marsupials, mRNA for this protein has also been found in human retina  .. 
+PF02159 Oestrogen receptor<br>
+PF04664 Opioid growth factor receptor (OGFr) conserved region<br>Pfam-B_4529 (release 7.5). Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus  .. 
+PF04680 OGFr_repeat; <br>Opioid growth factor receptor repeat. Pfam-B_4529 (release 7.5). Proline-rich repeat found only in a human opioid growth factor receptor  . . 
+PF04606 Ogr/Delta-like zinc finger<br>Pfam-B_5059 (release 7.5). This is a viral family of phage zinc-binding transcriptional activators, which also contains cryptic members in some bacterial genomes  . The P4 phage delta protein contains two such domains attached covalently, while the P2 phage Ogr proteins possess one domain but function as dimers. All the members of this family have the following consensus sequence: C-X(2)-C-X(3)-A-(X)2-R-X(15)-C-X(4)-C-X(3)-F  . This family also includes zinc fingers in recombinase proteins.. 
+PF01276 Orn/Lys/Arg decarboxylase, major domain<br>
+PF03711 Orn/Lys/Arg decarboxylase, C-terminal domain<br>
+PF03709 Orn/Lys/Arg decarboxylase, N-terminal domain<br>This domain has a flavodoxin-like fold, and is termed the "wing" domain because of its position in the overall 3D  structure.. 
+PF01277 Oleosin<br>
+PF02191 Olfactomedin-like domain<br>Alignment kindly provided by SMART. 
+PF00691 OmpA family<br>Pfam-B_166 (release 2.1). The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.. 
+PF01389 OmpA-like transmembrane domain<br>The structure of OmpA transmembrane domain shows that it consists of an eight stranded beta barrel  . This family includes some other distantly related outer membrane proteins with low scores.. 
+PF03938 Outer membrane protein (OmpH-like)<br>This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterised as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery  .. 
+PF01278 Omptin family<br>The omptin family is a family of  serine proteases.. 
+PF03922 OmpW family<br>This family includes outer membrane protein W (OmpW) proteins from a variety of bacterial species. This protein may form the receptor for S4 colicins in E. coli  .. 
+PF03532 OMS28 porin<br>
+PF02462 Opacity family porin protein<br>Pfam-B_2356 (release 5.4). Pathogenic Neisseria spp. possess a repertoire of phase-variable Opacity proteins that mediate various pathogen--host cell interactions  . These proteins are integral membrane proteins related to other porins.. 
+PF01160 Vertebrate endogenous opioids neuropeptide<br>
+PF04966 Carbohydrate-selective porin, OprB family<br>
+PF03573 Peptidase_S43; <br>outer membrane porin, OprD family. This family includes outer membrane proteins related to OprD. OprD has been described as a serine type peptidase  . However the proposed catalytic residues are not conserved suggesting that many of these proteins are not peptidases.. 
+PF03169 OPT oligopeptide transporter protein<br>Pfam-B_3048 (release 6.5). The OPT family of oligopeptide transporters is distinct from the ABC Pfam:PF00005 and PTR Pfam:PF00854 transporter families. OPT transporters were first recognised in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP  .. 
+PF04069 Substrate binding domain of ABC-type glycine betaine transport system<br>Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation.  This domain is often fused to the permease component of the transporter complex.  Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis  . The family member OpuBC is closely related, and involved in choline transport.  Choline is necessary for the biosynthesis of glycine betaine  .  L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).. 
+PF01718 Orbivirus non-structural protein NS1, or hydrophobic tubular protein<br>Pfam-B_1752 (release 4.1). This family consists of orbivirus non-structural protein NS1,  or hydrophobic tubular protein. NS1 has no specific function in  virus replication, it is however thought to play a role in  transport of mature virus particles from virus inclusion bodies  to the cell membrane  . Orbivirus are part of the larger reoviridae which have a dsRNA genome of at least 10 segments encoding at least 10 viral proteins  ; orbivirus found in this family include  bluetongue virus, and African horsesickness virus.. 
+PF01616 Orbivirus NS3<br>Pfam-B_1029 (release 4.1). The function of this Orbivirus non structural protein is uncertain.   However it may play a role on release of the virus from infected cells  .. 
+PF00898 Orbivirus outer capsid protein VP2<br>Pfam-B_1525 (release 2.1). VP2 acts as an anchor for VP1 and VP3. VP2 contains a non-specific  DNA and RNA binding domain in the N-terminus  .. 
+PF01700 Orbivirus VP3 (T2) protein<br>Pfam-B_1622 (release 4.1). The orbivirus VP3 protein is part of the virus core and makes a 'subcore' shell made up of 120 copies of the 100K protein  .   VP3 particles can also bind RNA and are fundamental in the  early stages of viral core formation  . Also found in the family is structural core protein VP2 from   broadhaven virus which is similar to VP3 in bluetongue  virus  . Orbivirus are part of the larger reoviridae which have a  dsRNA genome of 10-12 linear segments  ; orbivirus found in this family include bluetongue virus and epizootic hemorrhagic  disease virus. . 
+PF05059 Orbivirus VP4 core protein<br>Pfam-B_5992 (release 7.7). Orbiviruses are double stranded RNA retroviruses of which the bluetongue virus is a member. The core of bluetongue virus (BTV) is a multienzyme complex composed of two major proteins (VP7 and VP3) and three minor proteins (VP1, VP4 and VP6) in addition to the viral genome. VP4 has been shown to perform all RNA capping activities and has both methyltransferase type 1 and type 2 activities associated with it  .. 
+PF00901 Orbivirus outer capsid protein VP5<br>Pfam-B_1525 (release 2.1). cryoelectron microscopy indicates that VP5 is a trimer implying that there are 360 copies of VP5 per virion  . . 
+PF01516 Orbivirus helicase VP6<br>Pfam-B_765 (release 4.0). The VP6 protein a minor protein in the core of the virion is probably the viral helicase  .. 
+PF00897 Orbivirus inner capsid protein VP7<br>Pfam-B_1523 (release 2.1). In BTV, 260 trimers of VP7 are found in the core. The major proteins of the core are VP7 and VP3. VP7 forms an outer layer around VP3  .. 
+PF02072 Prepro-orexin<br>
+PF03827 Orexin receptor type 2<br>
+PF02999 Mlp; Orf-D; <br>Borrelia orf-D family. Pfam-B_1511 (release 6.4). Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames called Orf-A, Orf-B, Orf-C and Orf-D. This family corresponds to Orf-D. The putative product of this gene has no known function.. 
+PF04160 Orf-X; <br>Pfam-B_3014 (release 7.3). 
+PF04061 ORMDL family <br>Pfam-B_4871 (release 7.3);. Evidence form   suggests that ORMDLs are involved in protein folding in the ER.  Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).. 
+PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain<br>These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.. 
+PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain<br>These pyridoxal-dependent decarboxylases act on ornithine, lysine,  arginine and related substrates.  . 
+PF02088 Ornatin<br>
+PF02250 35kD major secreted virus protein <br>Pfam-B_3549 (release 5.2). This family of orthopoxvirus secreted proteins (also known as T1 and  A41) interact with members of both the CC and CXC superfamilies of  chemokines. It has been suggested that these secreted proteins  modulate leukocyte influx into virus-infected tissues  .. 
+PF00213 ATP synthase delta (OSCP) subunit<br>The ATP D subunit from E. coli  is the same as the OSCP subunit which is this family. The ATP D subunit from metazoa are found in family Pfam:PF00401.. 
+PF02566 OsmC-like protein<br>Pfam-B_2694 (release 7.0). Osmotically inducible protein C (OsmC) (Swiss:P23929) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein (Swiss:O68390) that  has a novel pattern of oxidative stress regulation  .. 
+PF03207 Borrelia outer surface protein D (OspD)<br>Pfam-B_2915 (release 6.5). 
+PF02471 OspEF; <br>Borrelia outer surface protein E. Pfam-B_962 (release 5.4). This is a family of outer surface proteins (Osp) from the Borrelia spirochete  . The family includes OspE, and OspEF-related proteins (Erp)  . These proteins are coded for on different circular plasmids in the Borrelia genome.. 
+PF03968 OstA-like protein<br>This family of proteins are mostly uncharacterised. However the family does include E. coli OstA Swiss:P31554 that has been characterised as an organic solvent tolerance protein  .. 
+PF04453 Organic solvent tolerance protein<br>Family involved in organic solvent tolerance in bacteria. The region contains several highly conserved, potentially catalytic, residues  .. 
+PF00865 Osteopontin<br>Pfam-B_1593 (release 2.1). 
+PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain<br>
+PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain<br>
+PF02338 OTU-like cysteine protease<br>This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.. 
+PF00724 oxidored_FMN; <br>NADH:flavin oxidoreductase / NADH oxidase family. Pfam-B_642 (release 2.1). 
+PF00174 oxidored_molyb; <br>Oxidoreductase molybdopterin binding domain. This domain is found in a variety of oxidoreductases. This domain binds to a molybdopterin cofactor. Xanthine dehydrogenases, that also bind molybdopterin, have essentially no similarity.. 
+PF00148 oxidored_nitro; <br>Nitrogenase component 1 type Oxidoreductase. 
+PF00361 oxidored_q1; <br>NADH-Ubiquinone/plastoquinone (complex I), various chains. Pfam-B_4 (release 1.0). This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.. 
+PF00662 oxidored_q1_N; <br>NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus. Pfam-B_22 (release 2.1). This sub-family represents an amino terminal extension of Pfam:PF00361. Only NADH-Ubiquinone chain 5 and eubacterial chain L are in this family. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.. 
+PF00420 oxidored_q2; <br>NADH-ubiquinone/plastoquinone oxidoreductase chain 4L. Pfam-B_193 (release 1.0). 
+PF00499 oxidored_q3; <br>NADH-ubiquinone/plastoquinone oxidoreductase chain 6. Pfam-B_61 (release 1.0). 
+PF00507 oxidored_q4; <br>NADH-ubiquinone/plastoquinone oxidoreductase, chain 3. Pfam-B_68 (release 1.0). 
+PF01059 oxidored_q5_N;<br>NADH-ubiquinone oxidoreductase chain 4, amino terminus. Pfam-B_381 (release 3.0). 
+PF01058 oxidored_q6; <br>NADH ubiquinone oxidoreductase, 20 Kd subunit. Pfam-B_1345 (release 3.0). 
+PF01237 Oxysterol-binding protein <br>
+PF00543 Nitrogen regulatory protein P-II<br>P-II modulates the activity of glutamine synthetase.. 
+PF04275 Phosphomevalonate kinase <br>TIGRFAMs (release 2.0);. Phosphomevalonate kinase (EC:2.7.4.2) catalyses the  phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate,  an essential step in isoprenoid biosynthesis via the mevalonate  pathway  . This family represents the animal type of the  enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see Pfam:PF00288).. 
+PF04699 p16_Arc; <br>ARP2/3 complex 16 kDa subunit (p16-Arc). Pfam-B_4180 (release 7.5). The Arp2/3 protein complex has been implicated in the control of actin polymerisation.  The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc.  The precise function of p16-Arc is currently unknown.  Its structure consists of a single domain containing a bundle of seven alpha helices [1,2].. 
+PF00864 ATP P2X receptor<br>Pfam-B_1590 (release 2.1). 
+PF04045 p34-Arc; <br>Arp2/3 complex, 34 kD subunit p34-Arc. Pfam-B_9846 (release 7.3);. Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc  .  This family represents the p34-Arc subunit.. 
+PF00067 Cytochrome P450<br>Overington and HMM_iterative_training. Cytochrome P450s are haem-thiolate proteins   involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures  .. 
+PF00870 P53 DNA-binding domain<br>Pfam-B_782 (release 3.0). This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.. 
+PF04636 PA26 p53-induced protein (sestrin)<br>Pfam-B_5416 (release 7.5). PA26 is a p53-inducible protein. Its function is unknown. It has similarity to Pfam:PF04636 in its N-terminus.. 
+PF02251 Proteasome activator pa28 alpha subunit<br>Pfam-B_2837 (release 5.2). PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.. 
+PF02252 Proteasome activator pa28 beta subunit<br>Pfam-B_2809 (release 5.2). PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.. 
+PF05138 Phenylacetic acid catabolic protein<br>This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid  . These proteins may form part of a dioxygenase complex.. 
+PF02758 PAAD_DAPIN;<br>PAAD/DAPIN/Pyrin domain. This domain is predicted to contain 6 alpha helices and to have the same fold as the Pfam:PF00531 domain.  This similarity may mean that this is a protein-protein interaction domain.. 
+PF00658 Poly-adenylate binding protein, unique domain<br>The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (Pfam:PF00076)  . Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.. 
+PF03068 Protein-arginine deiminase (PAD)<br>Pfam-B_2195 (release 6.4). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognised (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen  .. 
+PF04371 Porphyromonas-type peptidyl-arginine deiminase<br>Peptidyl-arginine deiminase (PAD) enzymes catalyse the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia.  PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (Pfam:PF03068), which is a metalloenzyme.  PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologues)  . The predicted catalytic residues in PPAD (Swiss:Q9RQJ2) are Asp130, Asp187, His236, Asp238 and Cys351  . These are absolutely conserved with the exception of Asp187 which is absent in two family members.  PPAD is also able to catalyse the deimination of free L-arginine, but has primarily peptidyl-arginine specificity.  It may have a FMN cofactor  .. 
+PF03551 Transcriptional regulator PadR-like family<br>Pfam-B_1014 (release 7.0). Members of this family are transcriptional regulators that appear to be related to the Pfam:PF01047 family. This family includes PadR Swiss:Q9EXE6 a protein that is involved in negative regulation of phenolic acid metabolism.. 
+PF03283 Pectinacetylesterase<br>Pfam-B_1589 (release 6.5). 
+PF03403 Platelet-activating factor acetylhydrolase, isoform II<br>Pfam-B_3469 (release 6.6). Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in Pfam:PF02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.. 
+PF03985 Paf1 <br>Pfam-B_ (release 7.3). Members of this family are components of the RNA polymerase II associated Paf1 complex.  The Paf1 complex functions during the  elongation phase of transcription in conjunction with Spt4-Spt5  and Spt16-Pob3i [1,2]. . 
+PF02671 Paired amphipathic helix repeat<br>Pfam-B_281 (release 5.4). This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene Swiss:P22579 (also known as SDI1) that is a negative regulator of the yeast HO gene  . This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.. 
+PF00221 PAL;<br>Aromatic amino acid lyase. This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities [1-3].. 
+PF02089 Palmitoyl protein thioesterase<br>
+PF02569 Pantoate-beta-alanine ligase<br>Pantoate-beta-alanine ligase, also know as pantothenate  synthase, (EC:6.3.2.1) catalyses the formation of pantothenate from pantoate and alanine  .. 
+PF02548 Ketopantoate hydroxymethyltransferase<br>Ketopantoate hydroxymethyltransferase (EC:2.1.2.11) is the first enzyme in the pantothenate biosynthesis pathway.. 
+PF02711 E4 protein<br>Pfam-B_1589 (release 5.5). This is is a family of Papillomavirus proteins, E4, coded for by  ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known  .. 
+PF04755 PAP_fibrillin<br>Pfam-B_3698 (release 7.5). This family identifies a conserved region found in a number of plastid lipid-associated proteins (PAPs), and in a number of putative fibrillin proteins.. 
+PF04926 Poly(A) polymerase predicted RNA binding domain<br>Pfam-B_1341 (release 7.6). Based on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding  .. 
+PF04795 PAPA-1-like conserved region<br>Pfam-B_6501 (release 7.5). Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein. . 
+PF03333 Adhesin biosynthesis transcription regulatory protein<br>Pfam-B_3068 (release 6.5). This family includes PapB, DaaA, FanA, FanB, and AfaA.. 
+PF03628 PapG chaperone-binding domain <br>Pfam-B_3074 (release 7.0). PapG, the adhesin of the P-pili, is situated at the tip and  is only a minor component of the whole pilus structure.  A two-domain structure has been postulated for PapG; a carbohydrate  binding N-terminus and chaperone binding C-terminus (this domain). The chaperone-binding domain is highly conserved, and is essential  for the correct assembly of the pili structure when aided by the  chaperone molecule PapD [1,2]. . 
+PF03627 PapG carbohydrate binding domain<br>Pfam-B_3074 (release 7.0). PapG, the adhesin of the P-pili, is situated at the tip and is only a minor component of the whole pilus structure.  A two-domain structure has been postulated for PapG; a carbohydrate binding N-terminus (this domain) and chaperone binding C-terminus. The carbohydrate-binding domain interacts with the receptor glycan [1,2].. 
+PF03025 Papillomavirus E5<br>Pfam-B_1916 (release 6.4). The E5 protein from papillomaviruses is about 80 amino acids long.  The proteins are contain three regions that are predicted to be transmembrane alpha helices.  The function of this protein is unknown.. 
+PF02380 T-antigen specific domain<br>Pfam-B_1131 (release 5.2). This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.. 
+PF01507 Phosphoadenosine phosphosulfate reductase family<br>Pfam-B_590 (release 4.0). This domain is found in phosphoadenosine phosphosulfate (PAPS) reductase enzymes or PAPS sulfotransferase. PAPS reductase is part of the adenine  nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases  . The enzyme uses thioredoxin as an electron  donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) [1,2]. It is also found in NodP nodulation protein P from Rhizobium which has ATP sulfurylase activity (sulfate adenylate transferase)  .   . 
+PF03285 Paralemmin<br>Pfam-B_4064 (release 6.5). 
+PF01508 Paramecium surface antigen domain<br>This domain is a cysteine rich extracellular repeat found in surface antigens of Paramecium.  The domain contains 8 cysteine residues. . 
+PF03210 Paramyx_P_V;<br>Paramyxovirus P/V phosphoprotein C-terminal. Pfam-B_2037 (release 6.5). Paramyxoviridae P genes are able to generate more than one product, using alternative reading frames and RNA editing. The P gene encodes the structural phosphoprotein P. In addition, it encodes several non-structural proteins present in the infected cell but not in the virus particle. This family includes phosphoprotein P and the non-structural phosphoprotein V from different paramyxoviruses.  Phosphoprotein P is essential for the activity of the RNA polymerase complex which it forms with another subunit, L Pfam:PF00946. Although all the catalytic activities of the polymerase are associated with the L subunit, its function requires specific interactions with phosphoprotein P  . The P and V phosphoproteins are amino co-terminal, but diverge at their C-termini. This difference is generated by an RNA-editing mechanism in which one or two non-templated G residues are inserted into P-gene-derived mRNA. In measles virus and Sendai virus, one G residue is inserted and the edited transcript encodes the V protein. In mumps, simian virus type 5 and Newcastle disease virus, two G residues are inserted, and the edited transcript codes for the P protein  . Being phosphoproteins, both P and V are rich in serine and threonine residues over their whole lengths. In addition, the V proteins are rich in cysteine residues at the C-termini  . This C-terminal region of the P phosphoprotein is likely to be the nucleocapsid-binding domain, and is found to be intrinsically disordered and thus liable to induced folding  .. 
+PF00946 Paramyx_RNA_pol;<br>Mononegavirales RNA dependent RNA polymerase . Pfam-B_586 (release 3.0). Members of the Mononegavirales including the Paramyxoviridae, like other non-segmented negative strand RNA viruses, have an RNA-dependent RNA polymerase composed of two subunits, a large protein L and a phosphoprotein P.\.   This is a protein family of the L protein. The L protein confers the RNA polymerase activity on the complex. The P protein acts as a transcription factor  .. 
+PF01692 Paramyxovirus non-structural protein c<br>Pfam-B_1202 (release 4.1). This family consist of the C proteins (C', C, Y1, Y2)  found in Paramyxovirinae; human parainfluenza, and sendai virus. The C proteins effect viral RNA synthesis having both a positive and negative effect during the course of infection  . Paramyxovirus have a negative strand ssRNA genome of 15.3kb  form which six mRNAs are transcribed, five of these are monocistronic.\.   The P/C mRNA is polycistronic and has two overlapping open reading  frames P and C, C encodes the nested C proteins C', C, Y1 and Y2  .. 
+PF00973 Paramyx_ncap;<br>Paramyxovirus nucleocapsid protein. Pfam-B_158 (release 3.0). The nucleocapsid protein is referred to as NP.  NP is is the major structural component of the nucleocapsid. The protein is approx. 58 kDa. 2600 NP molecules go to tightly encapsidate the RNA. NP interacts with several other viral encoded proteins, all of which are involved in controlling replication. {NP-NP, NP-P, NP-(PL), and NP-V}[1,2,3].. 
+PF02725 Non-structural protein C<br>Pfam-B_1636 (release 5.5). This family consists of the polymerase accessory protein C from members of the paramyxoviridae.. 
+PF01806 Paramyxovirinae P phosphoprotein C-terminal region<br>Pfam-B_1628 (release 4.1), Karlin D. The subfamily Paramyxovirinae of the family Paramyxoviridae now contains as main genera the Rubulaviruses, avulaviruses, respiroviruses, Henipavirus-es and morbilliviruses.  Protein P is the best characterised, structurally of the replicative complex of N, P and L proteins and consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT  . The P protein is an essential part of the viral RNA polymerase complex formed from the P and L proteins  . P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional.The C-terminal part of P (PCT) is only functional as an oligomer and forms with L the polymerase complex. PNT is poorly conserved and unstructured in solution while PCT contains the oligomerisation domain (PMD) that folds as a homotetrameric coiled coil (40) containing the L binding region and a C-terminal partially folded domain, PX (residues 474 to 568), identified as the nucleocapsid binding site. Interestingly, PX is also expressed as an independent polypeptide in infected cells. PX has a C-subdomain (residues 516 to 568) that consists of three {alpha}-helices arranged in an antiparallel triple-helical bundle linked to an unfolded flexible N-subdomain (residues 474 to 515).. 
+PF01279 Parathyroid hormone family<br>
+PF02195 ParB-like nuclease domain<br>Alignment kindly provided by SMART. 
+PF00644 Poly(ADP-ribose) polymerase catalytic domain<br>Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a  carboxyl 40 kDa fragment is still catalytically active  .. 
+PF02877 Poly(ADP-ribose) polymerase, regulatory domain<br>Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a  carboxyl 40 kDa fragment is still catalytically active  .. 
+PF01358 Poly A polymerase regulatory subunit<br>
+PF00740 Parvovirus coat protein VP2<br>Pfam-B_436 (release 2.1) & Pfam-B_445 (release 3.0). This protein, together with VP1 forms a capsomer. Both of these proteins are formed from the same transcript using alternative splicing.\.     As a result, VP1 and VP2 differ only in the N-terminal region of VP1.\.    VP2 is involved in packaging the viral DNA.. 
+PF01057 Parvovirus non-structural protein NS1<br>Pfam-B_400 (release 3.0). This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA  . NS1, is the major non-structural protein.  It is essential for DNA replication.  It is an 83-kDa nuclear phosphoprotein.  It has DNA helicase and ATPase activity  .  . 
+PF00989 PAS fold<br>Sequences from SMART alignment. The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs  . The PAS fold appears in archaea, eubacteria and eukarya.. 
+PF03793 PASTA domain<br>This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases  . It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.. 
+PF00292 'Paired box' domain<br>
+PF03535 Paxillin family<br>
+PF03717 Penicillin-binding Protein dimerisation domain<br>This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure.. 
+PF01395 PBP/GOBP family<br>Pfam-B_1765 (release 3.0). The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors  . This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).. 
+PF00427 Phycobilisome Linker polypeptide<br>Pfam-B_159 (release 1.0). 
+PF03792 PBX;<br>Pfam-B_3021 (release 7.0). The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins   . . 
+PF02229 Transcriptional Coactivator p15 (PC4)<br>Pfam-B_6534 (release 5.2). p15 has a bipartite structure composed of an amino-terminal  regulatory domain and a carboxy-terminal cryptic DNA-binding  domain  . The DNA-binding activity of the carboxy-terminal is disguised by the amino-terminal p15 domain. Activity is  controlled by protein kinases that target the regulatory domain.. 
+PF01851 Proteasome/cyclosome repeat<br>
+PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)<br>
+PF00705 PCNA; <br>Proliferating cell nuclear antigen, N-terminal domain. Pfam-B_598 (release 2.1). N-terminal and C-terminal domains of PCNA are topologically  identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.. 
+PF02747 Proliferating cell nuclear antigen, C-terminal domain<br>Pfam-B_598 (release 2.1). N-terminal and C-terminal domains of PCNA are topologically  identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.. 
+PF02429 Peridinin-chlorophyll A binding protein<br>Pfam-B_2945 (release 5.4). Peridinin-chlorophyll-protein, a water-soluble light-harvesting complex that has a blue-green absorbing carotenoid as its main pigment, is present in most photosynthetic dinoflagellates. These proteins are composed of two similar repeated domains. These domains constitute a scaffold with pseudo-twofold symmetry surrounding a hydrophobic cavity filled by two lipid, eight peridinin, and two chlorophyll a molecules  .. 
+PF01884 PcrB family<br>This family contains proteins that are related to PcrB Swiss:Q53726. The function of these proteins is unknown.. 
+PF04194 Programmed cell death protein 2, C-terminal putative domain <br>Pfam-B_19053 (release 7.3);. 
+PF04868 Retinal cGMP phosphodiesterase, gamma subunit<br>Pfam-B_4858 (release 7.6). Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit  , which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells  .. 
+PF00233 PDEase; <br>3'5'-cyclic nucleotide phosphodiesterase. 
+PF02112 cAMP phosphodiesterases class-II<br>
+PF00341 PDGF/VEGF domain<br>
+PF04692 Platelet-derived growth factor, N terminal region<br>This family consists of the amino terminal regions of platelet-derived  growth factor (PDGF, Pfam:PF00341) A and B chains.. 
+PF00800 Prephenate dehydratase<br>Pfam-B_1095 (release 2.1). This protein is involved in Phenylalanine biosynthesis. This protein catalyses the decarboxylation of prephenate to phenylpyruvate.. 
+PF03740 Pyridoxal phosphate biosynthesis protein PdxJ<br>Members of this family belong to the PdxJ family that catalyses the condensation of 1-deoxy-d-xylulose-5-phosphate (DXP) and 1-amino-3-oxo-4-(phosphohydroxy)propan-2-one to form pyridoxine 5'-phosphate (PNP). This reaction is involved in de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate  .. 
+PF00595 PDZ domain (Also known as DHR or GLGF)<br>PDZ domains are found in diverse signaling proteins.. 
+PF00544 pec_lyase; <br>This enzyme forms a right handed beta helix structure. Pectate lyase is an enzyme involved in the maceration and  soft rotting of plant tissue. . 
+PF05041 Pecanex protein (C-terminus)<br>Pfam-B_5192 (release 7.7). This family consists of C terminal region of the pecanex protein homologues. The pecanex protein is a maternal-effect neurogenic gene found in Drosophila  .. 
+PF03211 Pectate lyase<br>Pfam-B_2273 (release 6.5). 
+PF04191 Phospholipid methyltransferase <br>Pfam-B_14367 (release 7.3);. The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids  .. 
+PF03965 Pencillinase_R;<br>Penicillinase repressor. DOMO_DM03102 & Pfam-B_5099 (release 14.0). The penicillinase repressor negatively regulates  expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerisation of the  protein  . . 
+PF00805 Pentapeptide repeats (8 copies)<br>These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK  . The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix  . The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.. 
+PF00354 pentaxin; <br>Pentaxins are also known as pentraxins.. 
+PF02896 PEP-utilising enzyme, TIM barrel domain<br>
+PF01327 Polypeptide deformylase<br>
+PF01562 Reprolysin family propeptide<br>Pfam-B_117 (release 4.0). This region is the propeptide for members of peptidase family M12B.  The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.. 
+PF03413 Pep_M4_propep;<br>Peptidase propeptide and YPEB domain. This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase & Bacillus subtilis YPEB. . 
+PF00311 Phosphoenolpyruvate carboxylase<br>
+PF00821 Phosphoenolpyruvate carboxykinase<br>Pfam-B_1309 (release 2.1). Catalyses the formation of phosphoenolpyruvate by decarboxylation of  oxaloacetate.. 
+PF01293 Phosphoenolpyruvate carboxykinase<br>
+PF01195 Peptidyl-tRNA hydrolase<br>
+PF03564 Peptidase_A16; Peptidase_A16_N; <br>Protein of unknown function (DUF1759). This is a family of proteins of unknown function. Most of the members are gag-polyproteins.. 
+PF03566 Peptidase family A21<br>
+PF02160 Cauliflower mosaic virus peptidase (A3)<br>
+PF01828 Peptidase A4 family<br>
+PF01829 Peptidase A6 family<br>
+PF01252 SPASE_II; <br>Signal peptidase (SPase) II. 
+PF01640 Peptidase C10 family<br>Pfam-B_1522 (release 4.1). This family represents just the active peptide part of these proteins. Residues 1-120 are not part of the model as they form the pro-peptide, which before cleavage blocks the active site from the substrate.  The catalytic residues of histidine and cysteine are brought close together at the active site by the folding of the active peptide.. 
+PF03415 Clostripain family<br>
+PF01088 UCH; <br>Ubiquitin carboxyl-terminal hydrolase, family 1. 
+PF01470 Pyroglutamyl peptidase<br>
+PF01831 Peptidase C16 family<br>
+PF00648 Cys_protease_2;<br>Calpain family cysteine protease. 
+PF01478 Peptidase_C20; <br>Type IV leader peptidase family. Peptidase A24, or the prepilin peptidase as it is also known, processes the N-terminus of the prepilins  . The processing is essential for the correct formation of the pseudopili of type IV bacterial protein secretion. The enzyme is found across eubacteria and archaea  .. 
+PF03510 Endoptase_C24; <br>2C endopeptidase (C24) cysteine protease family. 
+PF01364 Peptidase family C25<br>Pfam-B_516 (release 3.0). 
+PF03785 Peptidase family C25, C terminal ig-like domain<br>Pfam-B_516 (release 3.0). 
+PF03412 Peptidase C39 family<br>Lantibiotic and non-lantibiotic bacteriocins are synthesised as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP-binding cassette (ABC) transporter. The ABC transporter is the maturation protease  and its proteolytic domain resides in the N-terminal part of the protein  .  This peptidase domain is found in a wide range of ABC transporters, however the presumed catalytic cysteine and histidine are not conserved in all members of this family.. 
+PF00770 Adenovirus endoprotease<br>Pfam-B_900 (release 2.1). This family of adenovirus thiol endoproteases specifically cleave Gly-Ala peptides in viral precursor peptides.. 
+PF03568 Peptidase family C50<br>
+PF03421 Peptidase_C55; <br>YopJ Serine/Threonine acetyltransferase. The Yersinia effector YopJ inhibits the innate immune response by blocking MAP kinase and NFkappaB signaling pathways.  YopJ is a serine/threonine acetyltransferase which regulates signalling pathways by blocking phosphorylation   .  Specifically, YopJ has been shown to block phosphorylation of active site residues  .  It has also been shown that YopJ acetyltransferase is activated by eukaryotic host cell inositol hexakisphosphate  . This family was previously incorrectly annotated in Pfam as being a peptidase family.. 
+PF03290 Pox_I7L_G1L; <br>Vaccinia virus I7 processing peptidase. Pfam-B_4082 (release 6.5). 
+PF00851 Helper component proteinase<br>Pfam-B_326 (release 3.0). This protein is found in genome polyproteins of potyviruses.. 
+PF01830 Peptidase C7 family<br>
+PF03569 Peptidase family C8<br>
+PF01707 Peptidase family C9<br>
+PF00413 matrixin; <br>The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.. 
+PF00675 Insulinase;<br>Insulinase (Peptidase family M16). Pfam-B_88 (release 2.1). 
+PF00883 Cytosol aminopeptidase family, catalytic domain<br>Pfam-B_990 (release 3.0). The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine  aminopeptidase.. 
+PF01401 Angiotensin-converting enzyme<br>Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.. 
+PF00557 pep_M24; <br>Metallopeptidase family M24. This family contains metallopeptidases.  It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module  .. 
+PF01742 Clostridial neurotoxin zinc protease<br>Pfam-B_407 (release 4.2). These toxins are zinc proteases that block neurotransmitter release by proteolytic cleavage of synaptic proteins such as synaptobrevins, syntaxin and SNAP-25.. 
+PF02073 Thermophilic metalloprotease (M29)<br>
+PF01432 Peptidase family M3<br>This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence.. 
+PF02074 Carboxypeptidase Taq (M32) metallopeptidase<br>
+PF02102 Deuterolysin metalloprotease (M35) family<br>
+PF02128 Fungalysin metallopeptidase (M36)<br>
+PF01447 Thermolysin metallopeptidase, catalytic domain<br>
+PF03410 Protein_G1; <br>Pfam-B_4417 (release 6.6). Protein G1, named after the vaccinia virus protein, is a glycoprotein expressed by many Poxviridae.. 
+PF01427 Peptidase_M45; <br>D-ala-D-ala dipeptidase. 
+PF01435 Peptidase family M48<br>
+PF03571 Peptidase family M49<br>
+PF02868 Thermolysin metallopeptidase, alpha-helical domain<br>
+PF04951 D-aminopeptidase<br>Bacillus subtilis DppA is a binuclear zinc-dependent, D-specific aminopeptidase. The structure reveals that DppA is a new example of a 'self-compartmentalising protease', a family of proteolytic complexes. Proteasomes are the most extensively studied representatives of this family. The DppA enzyme is composed of identical 30 kDa subunits organised in a decamer with 52 point-group symmetry. A 20 A wide channel runs through the complex, giving access to a central chamber holding the active sites. The structure shows DppA to be a prototype of a new family of metalloaminopeptidases characterised by the SXDXEG key sequence  . The only known substrates are D-ala-D-ala and D-ala-gly-gly.. 
+PF02031 Streptomyces extracellular neutral proteinase (M7) family<br>
+PF01457 Leishmanolysin<br>Prodom_3085 (release 99.1). 
+PF01752 Collagenase<br>This family of enzymes break down collagens.. 
+PF00768 D-alanyl-D-alanine carboxypeptidase<br>Pfam-B_864 (release 2.1). 
+PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family<br>
+PF02129 X-Pro dipeptidyl-peptidase (S15 family)<br>IPR000383 & Pfam-B_2704 (Release 7.5). 
+PF00716 Assemblin (Peptidase family S21)<br>Pfam-B_729 (release 2.1). 
+PF00717 Peptidase S24-like<br>Pfam-B_616 (release 2.1). 
+PF03572 Peptidase_S41;<br>Peptidase family S41. 
+PF03574 Peptidase family S48<br>
+PF03575 Peptidase family S51<br>
+PF03576 Peptidase_T4;<br>Peptidase family S58 . 
+PF00082 subtilase; <br>Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see Pfam:PF00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.. 
+PF00326 Prolyl_oligopep;<br>Prolyl oligopeptidase family. 
+PF03418 Peptidase_U3; Peptidase_M63; <br>Germination protease. 
+PF01136 Peptidase family U32<br>
+PF03577 Peptidase_U34; <br>Peptidase family C69. 
+PF03419 Sporulation factor SpoIIGA <br>
+PF03411 Peptidase_U6; <br>Penicillin-insensitive murein endopeptidase. 
+PF01343 Peptidase_U7; <br>Peptidase family S49. Pfam-B_707 (release 2.1). 
+PF03420 Prohead core protein protease<br>
+PF03036 perilipin; <br>Pfam-B_1154 (release 6.4). The perilipin family includes lipid droplet-associated protein  (perilipin) and adipose differentiation-related protein  (adipophilin).. 
+PF01497 Periplasmic binding protein<br>Pfam-B_461 (release 4.0). This family includes bacterial periplasmic binding proteins.  Several of which are involved in iron transport.. 
+PF00532 periplasmic_binding_like; <br>Periplasmic binding proteins and sugar binding domain of LacI family. MRC-LMB Genome group. This family includes the periplasmic binding proteins, and the LacI  family transcriptional regulators. The periplasmic binding  proteins are the primary receptors for chemotaxis and transport of many sugar based solutes.  The LacI family of proteins consist of  transcriptional regulators related to the lac repressor. In this case, generally the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain (Pfam:PF00356).. 
+PF00141 Peroxidase<br>Prosite; PfamB-105, Release 14.0;. 
+PF01328 Peroxidase, family 2<br>The peroxidases in this family do not have similarity to other peroxidases.. 
+PF04088 Peroxin 13, N-terminal region<br>Pfam-B_8055 (release 7.3);. Both termini of the Peroxin-13 are oriented to  the cytosol. Peroxin-13 is required for peroxisomal  association of peroxin-14  .. 
+PF04882 Peroxin-3<br>Pfam-B_6513 (release 7.6). Peroxin-3 is a peroxisomal protein. It is thought to be involve in membrane vesicle assembly prior to the translocation of matrix proteins  .. 
+PF03212 Pertactin<br>Pfam-B_2005 (release 6.5). 
+PF02917 Pertussis toxin, subunit 1<br>
+PF02918 Pertussis toxin, subunit 2 and 3, C-terminal domain<br>
+PF02529 Cytochrome B6-F complex subunit 5<br>Pfam-B_1348 (release 5.4). This family consists of cytochrome B6-F complex subunit 5 (PetG). The cytochrome bf complex found in green plants, eukaryotic algae and cyanobacteria, connects photosystem I to photosystem II in the electron  transport chain, functioning as a plastoquinol:plastocyanin/cytochrome c6 oxidoreductase  .  PetG or subunit 5 is associated with the bf complex and the absence of PetG affects either the assembly or stability of the  cytochrome bf complex in  Chlamydomonas reinhardtii  .. 
+PF05115 Cytochrome B6-F complex subunit VI (PetL)<br>Pfam-B_6510 (release 7.7). This family consists of several Cytochrome B6-F complex subunit VI (PetL) proteins found in several plant species. PetL is one of the small subunits which make up The cytochrome b(6)f complex. PetL is strictly required neither for the accumulation nor for the function of cytochrome b6f; in its absence, however, the complex becomes unstable in vivo in aging cells and labile in vitro.  It has been suggested that the N-terminus of the protein is likely to lie in the thylakoid lumen  .. 
+PF03742 PetN <br>Pfam-B_3260 (release 7.0). PetN is a small hydrophobic protein, crucial for cytochrome b6-f complex assembly and/or stability. . 
+PF04614 Pex19 protein family<br>
+PF04757 Pex2 / Pex12 amino terminal region<br>This region is found at the N terminal of a number of known and predicted peroxins including Pex2, Pex10 and Pex12. This conserved region is usually associated with a C terminal ring finger (Pfam:PF00097) domain.. 
+PF03011 PFEMP DBL domain<br>Pfam-B_822 (release 6.4). PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P.  falciparum [1,2].  Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes  . The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite  . A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains  . Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site  .. 
+PF00365 Phosphofructokinase<br>
+PF02901 Pyruvate formate lyase<br>
+PF01471 Putative peptidoglycan binding domain<br>Pfam-B_2277 (release 4.0). This domain is composed of three alpha helices  .  This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation  .  This domain may have a general peptidoglycan binding function.  This family is found N-terminal to the catalytic domain of matrixins  . The domain is found to bind peptidoglycan experimentally  .. 
+PF00300 PGAM;<br>Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches.  The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase.  The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases.  The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.. 
+PF00342 Phosphoglucose isomerase<br>Phosphoglucose isomerase catalyses the interconversion of glucose-6-phosphate and fructose-6-phosphate.. 
+PF00162 Phosphoglycerate kinase<br>
+PF00408 PGM_PMM; <br>Phosphoglucomutase/phosphomannomutase, C-terminal domain. 
+PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I<br>
+PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II<br>
+PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III<br>
+PF04608 Phosphatidylglycerophosphatase A<br>Pfam-B_5195 (release 7.5). This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli  .. 
+PF03334 Na+/H+ antiporter subunit<br>Pfam-B_3611 (release 6.5). This family includes PhaG from Rhizobium meliloti Swiss:Q9ZNG0, MnhG from Staphylococcus aureus Swiss:Q9ZNG0, YufB from Bacillus subtilis Swiss:O05227.. 
+PF02304 Scaffold protein B<br>Pfam-B_9648 (release 5.2). This is a family of proteins from single-stranded DNA bacteriophages.  Scaffold proteins B and D are required for procapsid formation.  Sixty copies of the internal scaffold protein B are found in the procapsid.. 
+PF04717 phage_base_V; <br>Phage-related baseplate assembly protein. Pfam-B_5996 (release 7.5). Family of phage baseplate assembly proteins responsible for forming the small spike at the end of the tail  . Also found in bacteria, probably the result of horizontal transmission.. 
+PF03864 Phage major capsid protein E<br>Major capsid protein E is involved with the stabilisation of the condensed form of the DNA molecule in phage heads  .. 
+PF05125 Phage major capsid protein, P2 family <br>TIGRFAMs (release 2.0);. 
+PF05144 Phage replication protein CRI  <br>TIGRFAMs (release 2.0);. The phage replication protein CRI, is also known as Gene II, is essential for DNA replication. . 
+PF02303 Helix-destabilising protein<br>Pfam-B_9239 (release 5.2). This family contains the bacteriophage helix-destabilising protein, or single-stranded DNA binding protein, required for DNA synthesis.. 
+PF02305 Capsid protein (F protein)<br>Pfam-B_10357 (release 5.2). This is a family of proteins from single-stranded DNA bacteriophages. Protein F is the major capsid component, sixty copies of which are found in the virion.. 
+PF03335 Phage tail fibre repeat<br>Pfam-B_3576 (release 6.5). 
+PF03406 Phage tail fibre repeat<br>Pfam-B_854 (release 6.6). This repeat is found in the tail fibres of phage. For example protein K Swiss:Q37842  . The repeats are about 40 residues long.. 
+PF02306 Major spike protein (G protein)<br>Pfam-B_8833 (release 5.2). This is a family of proteins from single-stranded DNA bacteriophages. Five G proteins, each a tight beta barrel, from twelve surface spikes. . 
+PF04688 Phage lysis protein, holin<br>This family constitutes holin proteins from the dsDNA Siphidoviridae group bacteriophages.  Most bacteriophages require an endolysin and a holin for host lysis.  During late gene expression, holins accumulate and oligomerise in the host cell membrane.  They then suddenly trigger to permeablise the membrane, which causes lysis by allowing endolysin to attach the peptidoglycan.  There are thought to be at least 35 different families of holin genes  .. 
+PF04531 Bacteriophage holin<br>Pfam-B_2644 (release 7.5). This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis  .. 
+PF04550 Phage holin family 2 <br>Pfam-B_61235 (release 7.0). Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis  .. 
+PF05106 Phage holin family (Lysis protein S)<br>TIGRFAMs (release 2.0);. This family represents one of a large number of mutually dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall.  This family includes the product of the S gene of phage lambda.. 
+PF05105 Holin; <br>TIGRFAMs (release 2.0);. Phage holins and lytic enzymes are both necessary for bacterial  lysis and virus dissemination.This family also includes TcdE/UtxA  involved in toxin secretion in Clostridium difficile  .. 
+PF00589 Phage integrase family<br>MRC-LMB Genome group. Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase  (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324.. 
+PF03245 Bacteriophage Rz lysis protein<br>Pfam-B_3219 (release 6.5). This protein is involved in host lysis. This family is not considered to be a peptidase according to the MEROPs database. This family Rz and the Rz1 protein (Pfam:PF06085) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway  .. 
+PF00959 Phage lysozyme<br>This family includes lambda phage lysozyme and E. coli endolysin.. 
+PF03863 Phage maturation protein<br>
+PF04233 Phage Mu protein F like protein<br>Members of this family are found in double-stranded DNA bacteriophages, and in some bacteria.  A member of this family is required for viral head  morphogenesis in bacteriophage SPP1 (Swiss:Q38577).  This family is  possibly a minor head protein. This family may be related to the family TT_ORF1 (Pfam:PF02956).. 
+PF05136 Phage portal protein, lambda family <br>TIGRFAMs (release 2.1);. This protein forms a hole, or portal, that enables DNA passage  during packaging and ejection.  It also forms the junction between  the phage capsid and the tail proteins. . 
+PF05133 Phage portal protein, SPP1 Gp6-like<br>TIGRFAMs (release 2.0);. This protein forms a hole, or portal, that enables DNA passage during packaging and ejection.  It also forms the junction between the phage head (capsid) and the tail proteins. During SPP1 morphogenesis, Gp6 participates in the procapsid assembly reaction [1,2]. This family also includes the old Pfam family Phage_min_cap (PF05126).. 
+PF05135 Phage_QLRG;<br>Phage gp6-like head-tail connector protein. TIGRFAMs (release 2.1);. This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97  . A structure of this protein shows similarity to gp15 a well characterised connector component of bacteriophage SPP1  .. 
+PF04492 Bacteriophage replication protein O      <br>Replication protein O is necessary for the initiation of bacteriophage DNA replication.  Protein O interacts with the lambda replication origin, and also with replication protein P to form an oligomer  . It is speculated that the N-terminal half interacts with the replication origin while the C terminal half mediates protein-protein interaction (annotation of Swiss: P14815).. 
+PF04984 Phage tail sheath protein<br>This family includes a variety of phage tail sheath proteins.. 
+PF04630 Phage major tail protein<br>Pfam-B_5341 (release 7.5). 
+PF05100 Phage minor tail protein L <br>TIGRFAMs (release 2.0);. 
+PF04761 Lactococcus bacteriophage putative transcription regulator<br>Pfam-B_3898 (release 7.5). This family represents a number of putative transcription repressor proteins found in several Lactococcus bacteriophages. Horizontal transfer may account for the presence of similar proteins in Lactococcus  .. 
+PF04985 Phage tail tube protein FII<br>The major structural components of the contractile tail of bacteriophage P2 are proteins FI and FII, which are believed to be the tail sheath and tube proteins, respectively.. 
+PF05155 Phage X family   <br>TIGRFAMs (release 2.1);. This family is the product of Gene X.  The function of this protein is unknown.. 
+PF02912 tRNA-synt_2_N; <br>Aminoacyl tRNA synthetase class II, N-terminal domain. 
+PF02332 Methane/Phenol/Toluene Hydroxylase<br>Pfam-B_15166 (release 5.2) & Pfam-B_3223 (Release 7.5). Bacterial phenol hydroxylase is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This Pfam family contains both the P1 and P3 polypeptides of phenol hydroxylase and the alpha and beta chain of methane hydroxylase protein A.. 
+PF04663 Phenol hydroxylase conserved region<br>Pfam-B_4509 (release 7.5). Under aerobic conditions, phenol is usually hydroxylated to catechol and degraded via the meta or ortho pathways. Two types of phenol hydroxylase are known: one is a multi-component enzyme the other is a single-component monooxygenase.  This region is found in both types of enzymes [1,2].. 
+PF04674 Phosphate-induced protein 1 conserved region<br>Pfam-B_4596 (release 7.5). Family of conserved plant proteins.  Conserved region identified in a phosphate-induced protein of unknown function  .. 
+PF03831 PhnA protein<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02562 PhoH-like protein<br>PhoH is a cytoplasmic protein and predicted ATPase that is  induced by phosphate starvation.. 
+PF02114 Phosducin<br>
+PF00068 phoslip; <br>Overington and HMM_iterative_training. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.. 
+PF04185 Phosphoesterase family<br>Pfam-B_1803 (release 7.3). This family includes both bacterial phospholipase C enzymes EC:3.1.4.3, but also eukaryotic acid phosphatases EC:3.1.3.2.. 
+PF04272 Phospholamban<br>TIGRFAMs (release 2.0);. The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation  . Phospholamban is thought to form a pentamer in the membrane  .. 
+PF00922 Vesiculovirus phosphoprotein<br>Pfam-B_1160 (release 3.0). 
+PF00343 phosphorylase; <br>Carbohydrate phosphorylase. The members of this family catalyse the formation of  glucose 1-phosphate from one of the following polyglucoses;   glycogen, starch, glucan or maltodextrin.. 
+PF00124 photoRC; <br>Photosynthetic reaction centre protein. 
+PF01895 DUF65; <br>This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle  . The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif.. 
+PF00502 Phycobilisome protein<br>Pfam-B_10 (release 1.0). 
+PF02333 Phytase<br>Pfam-B_14843 (release 5.2). Phytase is a secreted enzyme which hydrolyses phytate to release inorganic phosphate. This family appears to represent a novel enzyme that shows phytase activity   and has been shown to have a six- bladed propeller folding architecture  .. 
+PF04833 phytochel_synth; Phytochel_synth;<br>Pfam-B_4078 (release 7.6). Family of plant proteins are designated COBRA-like (COBL) proteins.  The 12 Arabidopsis members of the family are all GPI-liked  . Some members of this family are annotated as phytochelatin synthase, but these annotations are incorrect  .. 
+PF00360 phytochrome; Phytochrome;<br>Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to Pfam:PF01590  , which is generally located immediately N-terminal to this domain.  Compared with Pfam:PF01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilise the photoactivated far-red-absorbing state (Pfr)  . The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue  .. 
+PF03284 Phenazine biosynthesis protein A/B<br>Pfam-B_4020 (release 6.5). 
+PF00388 Phosphatidylinositol-specific phospholipase C, X domain<br>This associates with Pfam:PF00387 to form a single structural unit.. 
+PF00387 Phosphatidylinositol-specific phospholipase C, Y domain<br>This associates with Pfam:PF00388 to form a single structural unit.. 
+PF02192 PI3-kinase family, p85-binding domain<br>Alignment kindly provided by SMART. 
+PF00794 PI3-kinase family, ras-binding domain<br>Alignment kindly provided by SMART. Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly  significant similarity) to Ras-binding Pfam:PF00788 domains  (unpublished observation).. 
+PF00613 Phosphoinositide 3-kinase family, accessory domain (PIK domain)<br>Ponting C, Schultz J, Bork P. PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested   to be involved in substrate presentation.. 
+PF02226 Picornavirus coat protein (VP4)<br>Pfam-B_345 (release 5.2). VP1, VP2, VP3 and VP4 for the basic unit that forms the icosahedral coat of picornaviruses. Five symmetry-related N termini of coat protein VP4 form a ten-stranded, antiparallel beta barrel around the base of the icosahedral fivefold axis  .. 
+PF00947 Picornavirus core protein 2A<br>Pfam-B_138 (release 3.0). This protein is a protease, involved in cleavage of the polyprotein.. 
+PF01552 Picornavirus 2B protein<br>Pfam-B_214 (release 4.0). Poliovirus infection leads to drastic alterations in membrane permeability late during infection. Proteins 2B and 2BC enhance membrane permeability [1,2].. 
+PF00345 pili_assembly; Pili_assembly_N;<br>Pili and flagellar-assembly chaperone, PapD N-terminal domain. C2 domain-like beta-sandwich fold. This domain is the n-terminal part of the PapD chaperone protein for pilus and flagellar assembly.. 
+PF02753 pili_assembly_C; Pili_assembly_C;<br>Pili assembly chaperone PapD, C-terminal domain. Ig-like beta-sandwich fold. This domain is the C-terminal part of the pilus and flagellar-assembly chaperone protein PapD.. 
+PF00114 pilin; <br>Pilin (bacterial filament). Proteins with only the short N-terminal methylation site are not separated from the noise.\.     The Prosite pattern detects those better.. 
+PF05137 Fimbrial assembly protein (PilN)<br>
+PF04350 Pilus assembly protein, PilO<br>PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.. 
+PF04351 Pilus assembly protein, PilP<br>The PilP family are periplasmic proteins involved in the biogenesis of type IV pili  .. 
+PF04697 pinin_SDK_N; <br>pinin/SDK conserved region. Pfam-B_4141 (release 7.5). SDK2/3 is localised in nuclear speckles where as pinin is known to localise at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque [1,2]. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing  . pinin has also been implicated as a tumour suppressor.  The conserved region is found at the N-terminus of the member proteins  .. 
+PF00224 Pyruvate kinase, barrel domain<br>This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel.  The active site is found in a cleft between the two domains.. 
+PF02887 Pyruvate kinase, alpha/beta domain<br>As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.. 
+PF02827 cAMP-dependent protein kinase inhibitor<br>Members of this family are extremely potent competitive inhibitors of camp-dependent protein kinase activity. These proteins interact with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.. 
+PF02173 pKID domain<br>Pfam-B_1547 (Release 4.2). CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB  .. 
+PF03832 PkinA_anch; <br>This short motif is names after three conserved residues found in a WXSXK motif in protein kinase A anchoring proteins.. 
+PF00069 pkinase; <br>Protein kinase domain. 
+PF00433 pkinase_C; <br>Protein kinase C terminal domain. Pfam-B_135 (release 1.0). 
+PF02253 Phospholipase A1<br>Pfam-B_3500 (release 5.2). Phospholipase A1 is a bacterial outer membrane bound acyl hydrolase with a broad substrate specificity EC:3.1.1.32. It has been proposed  that Ser164 is the active site for Swiss:P00631  .. 
+PF01735 Lysophospholipase catalytic domain<br>Pfam-B_2127 (release 4.1). This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain Pfam:PF00168.  Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all  phospholipids extractable form yeast cells  .  Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids  , the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic  domain of the protein as discussed in  .. 
+PF02988 Phospholipase A2 inhibitor<br>Pfam-B_1254 (release 6.4). 
+PF00321 plant_thionins; <br>
+PF01307 Plant viral movement protein<br>Pfam-B_881 (release 3.0). This family includes several known plant viral movement proteins (e.g. Swiss:Q85292) from a number of different ssRNA plant virus families including potexviruses, hordeiviruses and carlaviruses. . 
+PF04819 Plant_viral_rep; <br>Family of unknown function (DUF716) . Pfam-B_5106 (release 7.6). This family is equally distributed in both metazoa and plants. Annotation associated with Swiss:Q9SLW7 suggest that it may be  involved in response to viral attack in plants.  However, no clear function has been assigned to this family.. 
+PF05015 Plasmid maintenance system killer protein<br>Several plasmids with proteic killer gene systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of those systems result in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.. 
+PF01672 Putative plasmid partition protein<br>Pfam-B_1163 (release 4.1). This family consists of conserved hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete, some of which are putative plasmid partition proteins  .. 
+PF05016 Plasmid stabilisation system protein<br>Members of this family are involved in plasmid stabilisation. The exact molecular function of this protein is not known. This family also encompasses RelE/ParE described in  .. 
+PF00681 Plectin_repeat;<br>Pfam-B_68 (release 2.1). This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.. 
+PF01523 Putative modulator of DNA gyrase<br>Pfam-B_845 (release 4.0). tldD and pmbA were found to suppress mutations in letD and inhibitor of DNA gyrase. Therefore it has been hypothesised that the TldD and PmbA proteins modulate the activity of DNA gyrase  . It has also been suggested that PmbA may be involved in secretion  .. 
+PF03332 Eukaryotic phosphomannomutase<br>Pfam-B_3713 (release 6.5). This enzyme EC:5.4.2.8 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.. 
+PF03901 PMP; <br>Alg9-like mannosyltransferase family. DOMO:DM04662 & Pfam-B_7750 (Release 8.0). Members of this family are mannosyltransferase enzymes [1-2].  At least some members are localised in endoplasmic reticulum and involved in GPI anchor biosynthesis [3-4].. 
+PF00822 PMP22; <br>PMP-22/EMP/MP20/Claudin family. Pfam-B_1393 (release 2.1). 
+PF01625 Peptide methionine sulfoxide reductase<br>Pfam-B_1111 (release 4.1). This enzyme repairs damaged proteins.  Methionine sulfoxide in proteins is reduced to methionine.. 
+PF02366 Dolichyl-phosphate-mannose-protein mannosyltransferase  <br>Pfam-B_556 (release 5.2). This is a family of Dolichyl-phosphate-mannose-protein mannosyltransferase proteins EC:2.4.1.109.  These proteins are responsible for O-linked glycosylation of proteins, they catalyse the reaction:- Dolichyl phosphate D-mannose + protein <=> dolichyl phosphate + O-D-mannosyl-protein.\. 
+PF03393 Pneumovirus matrix protein<br>Pfam-B_3641 (release 6.6). 
+PF03246 Pneumovirus nucleocapsid protein<br>Pfam-B_3020 (release 6.5). 
+PF03438 Pneumovirus NS1 protein<br>Pfam-B_3221 (release 6.6). This non-structural protein is one of two found in pneumoviruses. The protein is about 140 amino acids in length. The NS1 protein appears to be important for efficient replication but not essential  . The NS1 protein has been shown by yeast two-hybrid to interact with the viral P protein  . This protein is also known as the 1C protein. It has also been shown that NS1 can potently inhibit transcription and RNA replication  .. 
+PF02478 Pneumovirus phosphoprotein<br>Pfam-B_2290 (release 5.4). This family represents the phosphoprotein of Paramyxoviridae,  a putative RNA polymerase alpha subunit that may function in template binding.. 
+PF01048 Phosphorylase superfamily<br>Pfam-B_1190 (release 3.0). Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase). 
+PF02233 NAD(P) transhydrogenase beta subunit<br>Pfam-B_2220 (release 5.2). This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes.  The domain is often found in conjunction with Pfam:PF01262. Pyridine  nucleotide transhydrogenase catalyses the reduction of NAD+ to NADPH. A complete loss of activity occurs upon  mutation of Gly314 in  E. coli  .. 
+PF03833 DNA polymerase II large subunit DP2<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01620 Ribonuclease (pollen allergen)<br>Pfam-B_1050 (release 4.1). This family contains grass pollen proteins of group V. Swiss:Q40963 has been shown to possess ribonuclease activity  .. 
+PF01190 Pollen proteins Ole e I like<br>
+PF00659 POLO box duplicated region<br>
+PF02563 Polysaccharide biosynthesis/export protein<br>COGs & Pfam-B_1505 (Release 7.5). This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export.. 
+PF01743 Poly A polymerase head domain<br>Pfam-B_814 (release 4.2). This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.. 
+PF01518 Sigma NS protein<br>Pfam-B_803 (release 4.0). This viral protein has a poly(C)-dependent poly(G) polymerase activity  . . 
+PF00738 Polyhedrin<br>Pfam-B_423 (release 2.1). These proteins are found in occlusion bodies in various viruses. The polyhedrin protein protects the virus.. 
+PF03364 Polyketide cyclase / dehydrase and lipid transport<br>Mifsud W, Mistry J, Wood V. Pfam-B_1457 (release 6.6). This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.. 
+PF01736 Polyomavirus agnoprotein<br>Pfam-B_1917 (release 4.1). This family consist of the DNA binding protein or agnoprotein from various polyomaviruses. This protein is highly basic and can bind single stranded and double stranded DNA  . Mutations in the agnoprotein produce smaller viral plaques, hence its function is not essential for growth in tissue  culture cells but something has slowed in the normal replication  cycle  . There is also evidence suggesting that the agnogene and agnoprotein act as regulators of structural protein synthesis  .. 
+PF00718 Polyomavirus coat protein<br>Pfam-B_748 (release 2.1). 
+PF00761 Polyomavirus coat protein<br>Pfam-B_871 (release 2.1). 
+PF00348 Polyprenyl synthetase<br>
+PF01943 Polysaccharide biosynthesis protein<br>Members of this family are integral membrane proteins  . Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon  . The family includes SpoVB from Bacillus subtilis Swiss:Q00758, which is involved in spore cortex biosynthesis  .. 
+PF02719 Polysaccharide biosynthesis protein<br>Pfam-B_1536 (release 5.5). This is a family of diverse bacterial polysaccharide biosynthesis  proteins including the CapD protein (Swiss:P39853)  , WalL protein (Swiss:O86159) mannosyl-transferase (Swiss:O05349)   and several putative epimerases (e.g. WbiI Swiss:O69130).. 
+PF02530 Porin subfamily<br>Pfam-B_1122 (release 5.4). This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to Pfam:PF00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.   . 
+PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain<br>
+PF03900 Porphobilinogen deaminase, C-terminal domain<br>
+PF00280 Potato inhibitor I family<br>
+PF00767 Potyvirus coat protein<br>Pfam-B_868 (release 2.1). 
+PF00157 pou; <br>Pou domain - N-terminal to homeobox domain. 
+PF05061 Poxvirus A11 Protein<br>Pfam-B_5994 (release 7.7). Family of conserved Chordopoxvirinae A11 family proteins. Conserved region spans entire protein in the majority of family members.. 
+PF04651 Poxvirus A12 protein<br>Pfam-B_5523 (release 7.5). 
+PF04848 Poxvirus A22 protein<br>Pfam-B_4558 (release 7.6). 
+PF04584 Poxvirus A28 family<br>Pfam-B_4756 (release 7.5). Family of conserved Poxvirus A28 family proteins. Conserved region spans entire protein in the majority of family members.. 
+PF04665 Poxvirus A32 protein<br>Pfam-B_5586 (release 7.5). The A32 protein is thought to be involved in viral DNA packaging.. 
+PF04948 Poxvirus A51 protein <br>Pfam-B_6937 (release 7.6). 
+PF04924 Poxvirus A6 protein <br>Pfam-B_5792 (release 7.6). 
+PF04745 VITF-3 subunit protein<br>Pfam-B_6036 (release 7.5). Family of Chordopoxvirus proteins composing one of the two subunits that make up VITF-3, a virally encoded complex necessary for intermediate stage transcription  .. 
+PF04835 A9 protein conserved region<br>Pfam-B_4431 (release 7.6). Family of Chordopoxvirus A9 proteins. . 
+PF04508 Viral A-type inclusion protein repeat <br>The repeat is found in the A-type inclusion protein of the Poxvirus family  .  . 
+PF03286 Pox virus Ag35 surface protein<br>Pfam-B_4295 (release 6.5). 
+PF03336 Poxvirus C4/C10 protein<br>Pfam-B_3519 (release 6.5). 
+PF03287 Poxvirus C7/F8A protein<br>Pfam-B_4089 (release 6.5). 
+PF04701 Pox virus D2 protein<br>Pfam-B_5832 (release 7.5). 
+PF00874 BglG_antitermin;<br>Pfam-B_772 (release 3.0). The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators Pfam:PF03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99,  ) and inactive state (pdb:1tlv  ), revealing massive structural rearrangements upon activation.. 
+PF04580 Chordopoxvirinae D3 protein <br>Pfam-B_4684 (release 7.5). Chordopoxvirinae D3 protein conserved region.  Region occupies entire length of D3 protein.. 
+PF03288 Poxvirus D5 protein-like<br>Pfam-B_4009 (release 6.5). This family includes D5 from Poxviruses which is necessary for viral DNA replication, and is a nucleic acid independent nucleoside triphosphatase. Members of this family are also found outside of poxviruses. This domain is a DNA-binding winged HTH domain.. 
+PF04805 E10-like protein conserved region<br>Pfam-B_6357 (release 7.5). Family of poxvirus proteins.. 
+PF04497 Pox_E2;<br>Pfam-B_3979 (release 7.5). This family of proteins is restricted to Poxviridae.  It contains a number of differently named uncharacterised proteins.. 
+PF04656 Pox virus E6 protein<br>Pfam-B_4392 (release 7.5). Family of pox virus E6 proteins.. 
+PF03394 Poxvirus E8 protein<br>Pfam-B_3759 (release 6.6). 
+PF04943 Poxvirus F11 protein<br>Pfam-B_6911 (release 7.6). The protein F11 is an early virus protein.. 
+PF03337 Poxvirus F12L protein<br>Pfam-B_3082 (release 6.5). 
+PF04596 Poxvirus protein F15<br>Pfam-B_5182 (release 7.5). 
+PF04708 Poxvirus F16 protein<br>Pfam-B_5863 (release 7.5). 
+PF04767 DNA-binding 11 kDa phosphoprotein<br>Pfam-B_6128 (release 7.5). Family of poxvirus proteins required for virus morphogenesis. Protein function necessary for proteolytic processing of the major viral structural proteins, P4a and P4b  . . 
+PF04599 Poxvirus G5 protein<br>Pfam-B_5216 (release 7.5). This protein has been predicted to be related to the FEN-1 endonuclease  .. 
+PF04787 Late protein H7<br>Pfam-B_6266 (release 7.5). Family of poxvirus late H7 proteins.. 
+PF03289 Poxvirus protein I1<br>Pfam-B_4306 (release 6.5). 
+PF04661 Poxvirus I3 ssDNA-binding protein<br>Pfam-B_5571 (release 7.5). 
+PF04713 Poxvirus protein I5<br>Pfam-B_5901 (release 7.5). 
+PF04595 Poxvirus I6-like family<br>Pfam-B_5073 (release 7.5) & Pfam-B_6224 (release 8.0). This family includes I6 proteins as well as the related F5L proteins.. 
+PF03338 Poxvirus J1 protein<br>Pfam-B_3556 (release 6.5). 
+PF03339 Poxvirus L3/FP4 protein<br>Pfam-B_3380 (release 6.5). 
+PF00485 Phosphoribulokinase / Uridine kinase family<br>In Arabidopsis the region carries two binding domains, a phosphoribosylpyrophosphate-binding domain and, at the very C-terminus, a uracil-binding domain.. 
+PF04872 Poxvirus L5 protein family<br>Pfam-B_6088 (release 7.6). This family includes variola (smallpox) and vaccinia virus L5 proteins. However, not all  proteins in this family are called L5.  L5 is thought to contain a  metal-binding region  .. 
+PF03356 Viral late protein H2<br>Pfam-B_3929 (release 6.5). All Members of this family show similarity to the vaccinia virus late protein H2. This protein is often referred to by its gene name of H2R. Members from this family all belong to the viral taxon Poxviridae.. 
+PF04887 Poxvirus M2 protein<br>Pfam-B_6168 (release 7.6). This family includes M2 protein from variola virus.  The function of this protein is not known.. 
+PF03341 Poxvirus mRNA capping enzyme, small subunit<br>Pfam-B_3728 (release 6.5). The small subunit of the poxvirus mRNA capping enzyme has been found to have a structure which suggests that it started life as an RNA cap 2-prime O-methyltransferase. It has subsequently evolved to a catalytically inactive form that has been retained in order to help stabilise the large subunit, D1, and to enhance its methyltransferase activity through an allosteric mechanism  .. 
+PF03213 Poxvirus P35 protein<br>Pfam-B_2785 (release 6.5). 
+PF03395 Poxvirus P4A protein<br>Pfam-B_2985 (release 6.6). 
+PF03292 Poxvirus P4B major core protein<br>Pfam-B_4215 (release 6.5). 
+PF03296 Poxvirus poly(A) polymerase nucleotidyltransferase domain<br>Pfam-B_4019 (release 6.5). 
+PF03294 RNA polymerase-associated transcription specificity factor, Rap94<br>Pfam-B_4535 (release 6.5). 
+PF03340 Poxvirus rifampicin resistance protein<br>Pfam-B_3377 (release 6.5). 
+PF03293 Poxvirus DNA-directed RNA polymerase, 18 kD subunit<br>Pfam-B_4188 (release 6.5). 
+PF03396 Poxvirus DNA-directed RNA polymerase, 35 kD subunit<br>Pfam-B_3921 (release 6.6). 
+PF04490 Poxvirus T4 protein, C terminus<br>This family of poxvirus proteins are thought to be retained in the endoplasmic reticulum.  M-T4 of myxoma virus (Swiss:O55698) is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection  .. 
+PF04491 Poxvirus T4 protein, N terminus<br>This family of poxvirus proteins are thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C terminal region (Pfam:PF04490).  M-T4 of myxoma virus (Swiss:O55698) is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection  .. 
+PF03295 Poxvirus trans-activator protein A1 C-terminal<br>Pfam-B_4259 (release 6.5). 
+PF03355 Viral Trans-Activator Protein <br>Pfam-B_3956 (release 6.5). These proteins function as a trans-activator of viral late  genes.. 
+PF04441 Poxvirus early transcription factor (VETF), large subunit <br>Pfam-B_3920 (release 7.5). The poxvirus early transcription factor (VETF), in addition to  the viral RNA polymerase, is required for efficient transcription of early genes in vitro. VETF is a heterodimeric protein that binds  specifically to early gene promoters. The heterodimer is comprised of an 82 kDa (this family) subunit and a 70 kDa subunit. . 
+PF04947 Poxvirus Late Transcription Factor VLTF3 like <br>Members of this family are approximately 26 KDa, and are involved in trans-activator of late transcription  .. 
+PF04498 Poxvirus nucleic acid binding protein VP8/L4R<br>The 25 kDa product of Vaccinia virus gene L4R is also known as VP8.  VP8 is found in the cores of Vaccinia virions and is essential for the formation of transcriptionally competent viral particles.  It binds both single stranded and double stranded DNA and RNA with similar affinities.  Binding is thought to involve cooperative interactions between protein subunits. The protein is proteolytically cleaved during viral assembly at an Ala-Gly-Ala site. Possible roles for VP8 include packaging and maintaining the DNA genome in a transcribable configuration; binding ssDNA during transcription initiation; and cooperation with I8R protein to unwind early promoter regions.  VP8 may also function in either transcription elongation or release of mRNA molecules from viral particles  .. 
+PF04395 Poxvirus B22R protein<br>Pfam-B_3510 (release 7.3). This is highly conserved C-rich, central region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses. There are three pairs of conserved cysteine residues.. 
+PF00550 pp-binding; <br>Phosphopantetheine attachment site. A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.. 
+PF02503 Polyphosphate kinase middle domain<br>Pfam-B_2701 (release 5.4). Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.. 
+PF03012 Phosphoprotein<br>Pfam-B_1336 (release 6.4). This family includes the M1 phosphoprotein non-structural RNA polymerase alpha subunit, which is thought to be a  component of the active polymerase, and may be involved in template binding.. 
+PF02818 PPAK motif<br>These motifs are found in the PEVK region of titin.. 
+PF01326 PPDK_N_term; <br>Pyruvate phosphate dikinase, PEP/pyruvate binding domain. This enzyme catalyses the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).. 
+PF01239 Protein prenyltransferase alpha subunit repeat<br>Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognise a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognises a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family  .. 
+PF02541 Ppx/GppA phosphatase family<br>This family consists of the N-terminal region of exopolyphosphatase (Ppx) EC:3.6.1.11 and guanosine pentaphosphate phospho-hydrolase (GppA) EC:3.6.1.40.. 
+PF04403 Paraquat-inducible protein A<br>Paraquat is a superoxide radical-generating agent.  The promoter for the  pqiA gene is also inducible by other known superoxide generators  . This is predicted to be a family of integral membrane proteins, possibly  located in the inner membrane. This family is related to NADH dehydrogenase subunit 2 (Pfam:PF00361).. 
+PF01502 Phosphoribosyl-AMP cyclohydrolase<br>Pfam-B_782 (release 4.0). This enzyme catalyses the third step in the histidine biosynthetic pathway. It requires Zn ions for activity.. 
+PF01503 Phosphoribosyl-ATP pyrophosphohydrolase<br>Pfam-B_784 (release 4.0). This enzyme catalyses the second step in the histidine biosynthetic pathway.. 
+PF03208 PRA1 family protein<br>Pfam-B_2976 (release 6.5) & Pfam-B_8147 (Release 8.0). This family includes the PRA1 (Prenylated rab acceptor) protein which is a Rab guanine dissociation inhibitor (GDI) displacement factor  .  This family also includes the glutamate transporter EAAC1 interacting protein GTRAP3-18  .. 
+PF00697 N-(5'phosphoribosyl)anthranilate (PRA) isomerase<br>Pfam-B_247 (release 2.1). 
+PF03967 Photosynthetic reaction centre, H-chain N-terminal region<br>The family corresponds the N-terminal cytoplasmic domain.. 
+PF00432 prenyltrans; <br>Prenyltransferase and squalene oxidase repeat. Pfam-B_130 (release 1.0). 
+PF01080 Presenilin<br>Pfam-B_789 (release 3.0). Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease  .  It has been found that presenilin-1 (Swiss:P49768) binds to beta-catenin in-vivo  . This family also contains SPE proteins from C.elegans.. 
+PF03991 Prion_octopep;<br>Copper binding octapeptide repeat. This repeat is found at the amino terminus of prion proteins.  It has been shown to bind to copper.. 
+PF03063 Prismane/CO dehydrogenase family<br>Pfam-B_2956 (release 6.4). This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centres - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster.  The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested  . The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe  .  The CO dehydrogenase contains a Ni-3Fe-2S-3O centre.. 
+PF00484 Carbonic anhydrase<br>Prosite & Pfam-B_9319 (Release 8.0). This family includes carbonic anhydrases as well as a family of non-functional homologues related to YbcF.. 
+PF01619 Proline dehydrogenase<br>Pfam-B_1092 (release 4.1). 
+PF00160 pro_isomerase; <br>Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation.  Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA).  Other roles for cyclophilins may include chaperone and cell signalling function  .. 
+PF00235 profilin; <br>
+PF02161 Progesterone receptor<br>
+PF02244 Carboxypeptidase activation peptide<br>Pfam-B_2335 (release 5.2). Carboxypeptidases are found in abundance in pancreatic secretions.  The pro-segment moiety (activation peptide) accounts for up to a  quarter of the total length of the peptidase, and is responsible  for modulation of folding and activity of the pro-enzyme.. 
+PF04352 ProQ/FINO family<br>COG3109 & Pfam-B_7673 (release 7.7). This family includes ProQ, which is required for full activation of the osmoprotectant transporter, ProQ, in Escherichia coli. This family includes several bacterial fertility inhibition (FINO) proteins. The conjugative transfer of F-like plasmids is repressed by FinO, an RNA binding protein. FinO interacts with the F-plasmid encoded traJ mRNA and its antisense RNA, FinP, stabilising FinP against endonucleolytic degradation and facilitating sense-antisense RNA recognition  .. 
+PF02428 Potato type II proteinase inhibitor family<br>Pfam-B_2913 (release 5.4). Members of this family are proteinase inhibitors that contain eight cysteines that form four disulphide bridges. The structure of the proteinase-inhibitor complex is known  .. 
+PF00260 protamine_P1; <br>
+PF00841 protamine_P2; <br>Pfam-B_1350 (release 2.1). This protein also known as protamine P2 can substitute for histones in the chromatin of sperm (Swiss). The alignment contains both the sequence of the mature P2 protein and its propeptide.. 
+PF03247 Prothymosin/parathymosin family<br>Pfam-B_3463 (release 6.5). Prothymosin alpha and parathymosin are two ubiquitous small acidic nuclear proteins that are thought to be involved in cell cycle progression, proliferation, and cell differentiation  . . 
+PF05044 Prox1;<br>Homeo-prospero domain. Pfam-B_5293 (release 7.7). Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos.  It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain.  However, the structure shows that these two regions form a single stable structural domain as defined here  .  This homeo-prospero domain binds to DNA.. 
+PF02840 Prp18 domain<br>The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known  . This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles  .. 
+PF02340 PRRSV putative envelope protein<br>Pfam-B_939 (release 5.2). This family consists of a conserved probable envelope protein  or ORF2 in porcine reproductive and respiratory syndrome virus (PRRSV) also in the family is a minor structural protein from lactate dehydrogenase-elevating virus.. 
+PF01366 Herpesvirus processing and transport protein<br>Pfam-B_1171 (release 3.0). The members of this family are associate with capsid intermediates during packaging of the virus.. 
+PF02666 Phosphatidylserine decarboxylase<br>This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65.   These enzymes catalyse the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2.  Phosphatidylserine decarboxylase plays  a central role in the biosynthesis of aminophospholipids by converting  phosphatidylserine to phosphatidylethanolamine  .. 
+PF04230 Polysaccharide pyruvyl transferase<br>Pyruvyl-transferases involved in peptidoglycan-associated polymer  biosynthesis.  CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides.  WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora  .. 
+PF00223 psaA_psaB;<br>Photosystem I psaA/psaB protein. 
+PF02531 PsaD<br>Pfam-B_1336 (release 5.4). This family consists of PsaD from plants and cyanobacteria. PsaD is an extrinsic polypeptide of photosystem I (PSI) and is required for native assembly of PSI reaction clusters and is implicated in the  electrostatic binding of ferredoxin within the reaction centre  . PsaD forms a dimer in solution which is bound by PsaE however PsaD is monomeric in its native complexed PSI environment  .. 
+PF02605 Photosystem I reaction centre subunit XI<br>Pfam-B_1741 (release 5.4). This family consists of the photosystem I reaction centre subunit XI, PsaL, from plants and bacteria.  PsaL is one of the smaller subunits in photosystem I with only two transmembrane alpha helices and interacts closely with PsaI  .. 
+PF00737 PSBH; <br>Photosystem II 10 kDa phosphoprotein. Pfam-B_465 (release 2.1). This protein is phosphorylated in a light dependent reaction.. 
+PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)<br>Pfam-B_1731 (release 5.4). This family consists of various Photosystem II (PSII) reaction centre I proteins or PSII 4.8 kDa proteins, PsbI, from the chloroplast genome of many plants and Cyanobacteria. PsbI is a small, integral membrane component of PSII the role of which is not clear  .  Synechocystis mutants lacking  PsbI have 20-30% loss of PSII activity however the PSII complex is not  destabilised  .. 
+PF01788 PsbJ<br>Pfam-B_1227 (release 4.2). This family consists of the photosystem II reaction centre protein PsbJ from plants and Cyanobacteria.  In Synechocystis sp. PCC 6803 PsbJ regulates the number of  photosystem II centres in thylakoid membranes, it is a predicted 4kDa protein with one membrane spanning domain  .. 
+PF02533 Photosystem II 4 kDa reaction centre component<br>Pfam-B_1331 (release 5.4). This family consists of various photosystem II 4 kDa reaction centre components (PsbK) from plant and Cyanobacteria.  The photosystem II reaction centre is responsible for catalysing the core photosynthesis reaction the light-induced splitting of water and the consequential release of dioxygen.  In C. reinhardtii the psbK product is required for the stable assembly and/or stability of the photosystem II complex  .. 
+PF02419 PsbL protein<br>Pfam-B_1884 (release 5.4). This family consists of the photosystem II reaction centre protein PsbJ from plants and Cyanobacteria. The function of this small  protein is unknown. Interestingly the mRNA for this protein requires a post-transcriptional modification of an ACG triplet to form an AUG initiator codon [1,2].. 
+PF05151 Photosystem II reaction centre M protein (PsbM)<br>Pfam-B_6558 (release 7.7). This family consists of several Photosystem II reaction centre M proteins (PsbM) from plants and cyanobacteria. During the photosynthetic light reactions in the thylakoid membranes of cyanobacteria, algae, and plants, photosystem II (PSII), a multi-subunit membrane protein complex, catalyses oxidation of water to molecular oxygen and reduction of plastoquinon  .. 
+PF02468 psbN; <br>Photosystem II reaction centre N protein (psbN). Pfam-B_2222 (release 5.4). This is a family of small proteins encoded on the chloroplast genome. psbN is involved in photosystem II during photosynthesis, but its exact role is unknown.. 
+PF04725 Photosystem II 10 kDa polypeptide PsbR<br>This protein is associated with the oxygen-evolving complex of photosystem II.  Its function in photosynthesis is not known.  The C-terminal hydrophobic region functions as a thylakoid transfer signal but is not removed  .. 
+PF01405 PSBT; <br>Photosystem II reaction centre T protein. Pfam-B_1880 (release 3.0). The exact function of this protein is unknown. It probably consists of a single transmembrane spanning helix. The Swiss:P37256 protein, appears to be (i) a novel photosystem II subunit and (ii) required for maintaining optimal photosystem II activity under adverse growth conditions  .. 
+PF03912 PsbW; <br>Psb28 is a 13 kDa soluble protein that is directly assembled in dimeric PSII supercomplexes.  The negatively charged N-terminal region is essential for this process  . This protein was formerly known as PsbW, but PsbW is now reserved for Pfam:PF07123.. 
+PF00849 YABO;<br>RNA pseudouridylate synthase. Pfam-B_421 (release 3.0). Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD Swiss:P33643, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA  .. 
+PF00796 Photosystem I reaction centre subunit VIII<br>Pfam-B_528 (release 2.1). 
+PF02427 Photosystem I reaction centre subunit IV / PsaE<br>Pfam-B_1594 (release 5.4). PsaE is a 69 amino acid polypeptide from photosystem I present on the stromal side of the thylakoid membrane  . The structure is comprised of a well-defined five-stranded beta-sheet similar to SH3 domains  .. 
+PF02507 Photosystem I reaction centre subunit III<br>Pfam-B_2122 (release 5.4). Photosystem I (PSI) is an integral membrane protein complex that  uses light energy to mediate electron transfer from plastocyanin to ferredoxin. Subunit III (or PSI-F) is one of at least 14 different subunits that compose the PSI complex.. 
+PF03244 Photosystem I reaction centre subunit VI<br>Pfam-B_3007 (release 6.5). Photosystem I (PSI) is an integral membrane protein complex that uses light energy to mediate electron transfer from plastocyanin to ferredoxin.. 
+PF01701 Photosystem I reaction centre subunit IX / PsaJ<br>Pfam-B_1599 (release 4.1). This family consists of the photosystem I reaction centre subunit IX or PsaJ from various organisms including Synechocystis sp. (strain pcc 6803), Pinus thunbergii (green pine) and Zea mays (maize). PsaJ Swiss:P19443 is a small 4.4kDa, chloroplastal encoded, hydrophobic subunit of the photosystem I reaction complex its function is not yet fully understood  . PsaJ can be cross-linked to PsaF Swiss:P12356 and has a single predicted transmembrane domain it has a proposed role in maintaining PsaF in the correct orientation to allow for fast electron transfer from soluble donor proteins to P700+  .. 
+PF01241 Photosystem I psaG / psaK<br>
+PF00421 Photosystem II protein<br>Pfam-B_182 (release 1.0). 
+PF04012 PspA/IM30 family<br>This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator  .. 
+PF04839 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)<br>Pfam-B_2979 (release 7.6). This small acidic protein is found in 30S ribosomal subunit of cyanobacteria and plant plastids.\.       In plants it has been named plastid-specific ribosomal protein 3 (PSRP-3), and in cyanobacteria it is named Ycf65.  Plastid-specific ribosomal proteins may mediate the effects of nuclear factors on plastid translation.  The acidic PSRPs are thought to contribute to protein-protein interactions in the 30S subunit, and are not thought to bind RNA  .. 
+PF03034 Phosphatidyl serine synthase<br>Pfam-B_1414 (release 6.4). Phosphatidyl serine synthase is also known as serine exchange enzyme.  This family represents eukaryotic PSS I and II which are membrane bound proteins which catalyses the replacement of the head group of a phospholipid (phosphotidylcholine or phosphotidylethanolamine) by L-serine.. 
+PF01515 Phosphate acetyl/butaryl transferase<br>Pfam-B_799 (release 4.0). This family contains both phosphate acetyltransferase and phosphate butaryltransferase.  These enzymes catalyse the transfer of an acetyl or butaryl group to orthophosphate.. 
+PF02126 Phosphotriesterase family<br>
+PF00809 DHPS; <br>Pterin binding enzyme. Pfam-B_1411 (release 2.1) and Pfam-B_3423 (release 6.6). This family includes a variety of pterin binding enzymes that all adopt a TIM barrel fold. The family includes dihydropteroate synthase EC:2.5.1.15 as well as a group methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) Swiss:Q46389 that catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation. It transfers the N5-methyl group from methyltetrahydrofolate (CH3-H4folate) to a cob(I)amide centre in another protein, the corrinoid iron-sulfur protein. MeTr is a member of a family of proteins that includes methionine synthase and methanogenic enzymes that activate the methyl group of methyltetra-hydromethano(or -sarcino)pterin  .. 
+PF01091 PTN_MK; <br>PTN/MK heparin-binding protein family, C-terminal domain. 
+PF05196 PTN/MK heparin-binding protein family, N-terminal domain<br>
+PF04387 Protein tyrosine phosphatase-like protein, PTPLA<br>Pfam-B_1525 (release 7.3). This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types  .. 
+PF01242 6-pyruvoyl tetrahydropterin synthase<br>6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits  .. 
+PF00854 POT family<br>Pfam-B_571 (release 3.0). The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters  .. 
+PF00381 PTS HPr component phosphorylation site<br>
+PF01885 DUF60; <br>RNA 2'-phosphotransferase, Tpt1 / KptA family. Tpt1 catalyses the last step of tRNA splicing in yeast.  It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate.  This is presumed to be followed by a transesterification step to release the RNA.\.     The first step of this reaction is similar to that catalysed by some bacterial toxins.\.        E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism  .. 
+PF00358 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1<br>
+PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2<br>
+PF00367 phosphotransferase system, EIIB<br>
+PF02378 Phosphotransferase system, EIIC <br>Pfam-B_639 (release 5.2). The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.. 
+PF02255 PTS system, Lactose/Cellobiose specific IIA subunit<br>Pfam-B_3710 (release 5.2). The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a  variety of metabolic and transcriptional processes.  The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilised by a centrally located metal ion  . Separation into subunits is thought to occur after phosphorylation. . 
+PF03714 Bacterial pullanase-associated domain<br>Domain is found in pullanase - carbohydrate de-branching - proteins. It is found both to the N or the C terminii of of the alpha-amylase active site region. This domain contains several conserved aromatic residues that are suggestive of a carbohydrate binding function.. 
+PF03829 PTS system glucitol/sorbitol-specific IIA component<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03830 PTS system sorbose subfamily IIB component<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03209 PUCC protein<br>Pfam-B_2839 (release 6.5). This protein is required for high-level transcription of the PUC operon.. 
+PF00806 Pumilio-family RNA binding repeat<br>Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA).  Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognise all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats.  Structures of PUF repeat proteins show they consist of a two helix structure [3,4].. 
+PF02245 Methylpurine-DNA glycosylase (MPG)<br>Pfam-B_3352 (release 5.2). Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.. 
+PF04845 PurA ssDNA and RNA-binding protein<br>Pfam-B_4535 (release 7.6). This family represents most of the length of the protein.. 
+PF02700 UPF0062; PurC;<br>Phosphoribosylformylglycinamidine (FGAM) synthase. This family forms a component of the de novo purine biosynthesis pathway. . 
+PF00855 PWWP domain<br>The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif  . The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organising higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression  .. 
+PF02436 Conserved carboxylase domain<br>Pfam-B_628 (release 5.2). This domain represents a conserved region in pyruvate carboxylase  (PYC), oxaloacetate decarboxylase alpha chain (OADA), and  transcarboxylase 5s subunit. The domain is found adjacent to the  HMGL-like domain (Pfam:PF00682) and often close to the biotin_lipoyl domain (Pfam:PF00364) of biotin requiring enzymes. . 
+PF03013 Pyrimidine dimer DNA glycosylase<br>Pfam-B_1388 (release 6.4). Pyrimidine dimer DNA glycosylases excise pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond. Pyrimidine dimers are the major UV-lesions of DNA.. 
+PF01948 Aspartate carbamoyltransferase regulatory chain, allosteric domain<br>The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The N-terminal domain has ferredoxin-like fold, and provides the  regulatory chain dimerisation interface.. 
+PF02748 Aspartate carbamoyltransferase regulatory chain, metal binding domain<br>The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The C-terminal metal binding domain has a rubredoxin-like fold and  provides the interface with the catalytic chain.. 
+PF01243 Pyridoxamine 5'-phosphate oxidase<br>
+PF00282 pyridoxal_deC; <br>Pyridoxal-dependent decarboxylase conserved domain. 
+PF00719 Inorganic pyrophosphatase<br>Pfam-B_613 (release 2.1). 
+PF02547 Queuosine biosynthesis protein<br>Queuosine (Q) biosynthesis protein, or S-adenosylmethionine:tRNA -ribosyltransferase-isomerase, is required for the synthesis of the queuosine precursor (oQ). It catalyses the transfer and isomerisation of the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to form epoxyqueuosine (oQ-tRNA).  Q is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine, aspartate, histidine, and tyrosine tRNAs [1,2]. In Streptococcus gordonii , QueA has been shown to play a role in the regulation of arginine deiminase genes  .. 
+PF00788 Ras association (RalGDS/AF-6) domain<br>Alignment kindly provided by SMART. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure   similar to that determined  , and that of the RasGTP-binding domain of Raf kinase.. 
+PF03528 Rabaptin<br>
+PF02144 Repair protein Rad1/Rec1/Rad17<br>
+PF03215 Rad17 cell cycle checkpoint protein<br>Pfam-B_2764 (release 6.5). 
+PF04824 Conserved region of Rad21 / Rec8 like protein<br>Pfam-B_2686 (release 7.6). This family represents a conserved region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families.  Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex  . Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation.  These proteins may also be involved in chromosome condensation.  Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation  .. 
+PF04825 N terminus of Rad21 / Rec8 like protein<br>Pfam-B_2686 (release 7.6). This family represents a conserved N-terminal region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families.  Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex  . Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation.  These proteins may also be involved in chromosome condensation.  Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation  .. 
+PF03835 Rad4 transglutaminase-like domain<br>
+PF04098 Rad52/22 family double-strand break repair protein<br>The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52  . These proteins contain two helix-hairpin-helix motifs  .. 
+PF04139 Rad9<br>Pfam-B_28077 (release 7.3);. Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage.  It contains a Bcl-2 homology domain 3 (BH3)  .. 
+PF04002 RadC; DUF2466;<br>RadC-like JAB domain. A family of proteins present widely across the bacteria. This family was named initially with reference to the E. coli radC102 mutation which suggested that RadC was involved in repair of DNA lesions  . However the relevant mutation has subsequently been shown to be in recG, where radC is in fact an allele of recG  . In addition, a personal communication from Claverys, J-P, et al, indicates a total failure of all attempts to characterise a radiation-related function for RadC in Streptococcus pneumoniae, suggesting that it is not involved in repair of DNA lesions, in recombination during transformation, in gene conversion, nor in mismatch repair. Computational analysis, however, provides a possible function. The RadC-like family belong to the JAB superfamily  of metalloproteins  . The domain shows fusions to an N-terminal  Helix-hairpin-Helix (HhH) domain in most instances. Other domain combinations include fusions to the anti-restriction module ArdC, the DinG/RAD3-like superfamily II helicases and the DNAG-like primase. In some bacteria, closely related DinG/Rad3- like superfamily II helicases are fused to a 3'-5' exonuclease in the  same position as the RadC-like JAB domain. These conserved domain  associations lead to the hypothesis that the RadC-like JAB domains  might function as a nuclease  .. 
+PF04712 Radial spokehead-like protein<br>Pfam-B_5891 (release 7.5). This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene  .. 
+PF03089 Recombination activating protein 2<br>Pfam-B_4702 (release 6.5). V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity  is generated from a limited amount of genetic material.  This  process is synergistically activated by RAG1 and RAG2 in  developing lymphocytes.  Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.. 
+PF04901 Receptor activity modifying family <br>Pfam-B_5615 (release 7.6). The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying  protein or RAMP. RAMPs are single-transmembrane-domain proteins  . . 
+PF00638 RanBP1 domain<br>
+PF03085 Rhoptry-associated protein 1 (RAP-1)<br>Pfam-B_1750 (release 6.4). Members of this family are found in Babesia species. Though not in this Pfam family, rhoptry-associated proteins are also found in Plasmodium falciparum. Indeed, animal infection with Babesia may produce a pattern similar to human malaria  . Rhoptry organelles form part of the apical complex in apicomplexan parasites. Rhoptry-associated proteins are antigenic, and generate partially protective immune responses in infected mammals. Thus RAPs are among the targeted vaccine antigens for babesial (and malarial) parasites. However, RAP-1 proteins are encoded by by a multigene family; thus RAP-1 proteins are polymorphic, with  B and T cell epitopes that are conserved among strains, but not across species [1,2,5]. Antibodies to Babesia RAP-1 may also be helpful in the  serological detection of Babesia infections  .. 
+PF00071 ras; <br>Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head.  See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices  .. 
+PF00616 GTPase-activator protein for Ras-like GTPase<br>Ponting C, Schultz J, Bork P. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position.. 
+PF03836 RasGAP C-terminus<br>
+PF00617 RasGEF domain<br>Ponting C, Schultz J, Bork P. Guanine nucleotide exchange factor for Ras-like small GTPases.. 
+PF00618 RasGEFN; <br>RasGEF N-terminal motif. Ponting C, Schultz J, Bork P. A subset of guanine nucleotide exchange factor for Ras-like small  GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.. 
+PF01858 Retinoblastoma-associated protein A domain<br>This domain has the cyclin fold   as predicted  .. 
+PF01857 Retinoblastoma-associated protein B domain<br>The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain  .  The B domain has a cyclin fold. . 
+PF02196 Raf-like Ras-binding domain<br>Alignment kindly provided by SMART. 
+PF02033 Ribosome-binding factor A<br>
+PF05025 RbsD / FucU transport protein family<br>Pfam-B_4828 (release 7.6). The Escherichia coli high-affinity ribose-transport system consists of six proteins encoded by the rbs operon (rbsD, rbsA, rbsC, rbsB, rbsK and rbsR). Of the six components, RbsD is the only one whose function is unknown although it is thought that it somehow plays a critical role in  PtsG-mediated ribose transport  . This family also includes FucU a protein from the fucose biosynthesis operon that is presumably also involved in fucose transport by similarity to RbsD.. 
+PF02341 RbcX protein<br>Pfam-B_948 (release 5.2). The RBCX protein has been identified as having a possible  chaperone-like function  .  The rbcX gene is juxtaposed to and cotranscribed with rbcL and rbcS encoding RuBisCO in Anabaena sp. CA  . RbcX has been shown to possess a chaperone-like  function assisting correct folding of RuBisCO in E. coli expression  studies and is needed for RuBisCO to reach its maximal activity  .. 
+PF00415 Regulator of chromosome condensation (RCC1) repeat<br>
+PF04381 Putative exonuclease, RdgC<br>Members of the RdgC family may have exonuclease activity. RdgC is required for efficient pilin variation in Neisseria gonorrhoeae, suggesting that it may be involved in recombination reactions  . In Escherichia coli, RdgC is required for growth in recombination-deficient exonuclease-depleted strains.  Under these conditions, RdgC may act as an exonuclease to remove collapsed replication forks, in the absence of the normal repair mechanisms  .. 
+PF05183 RNA dependent RNA polymerase<br>Pfam-B_2226 (release 7.7). This family of proteins are eukaryotic RNA dependent RNA polymerases. These proteins are involved in post transcriptional gene silencing where they are thought to amplify dsRNA templates.. 
+PF00154 recA; <br>recA bacterial DNA recombination protein. RecA is a DNA-dependent ATPase and functions in DNA repair systems.  RecA protein catalyses an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination  .. 
+PF02565 RecO;<br>Recombination protein O C terminal. Recombination protein O (RecO) is involved in DNA repair and Pfam:PF00470 pathway recombination.. 
+PF02132 RecR protein<br>
+PF03837 RecT family<br>The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to RecT  .. 
+PF03838 Recombination protein U<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02631 RecX family<br>RecX is a putative bacterial regulatory protein  . The gene  encoding RecX is found downstream of recA, and is thought to interact with the RecA protein.   . 
+PF02014 Reeler domain<br>
+PF04221 DUF415; <br>RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes ( ,  ). RelB stably binds RelE, presumably deactivating it.. 
+PF03763 Remorin, C-terminal region <br>Pfam-B_1798 (release 7.0). Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible.. 
+PF03766 Remorin, N-terminal region <br>Pfam-B_1798 (release 7.0). Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible. . 
+PF01244 Renal_dipeptase; <br>Membrane dipeptidase (Peptidase family M19). 
+PF01664 Reovirus viral attachment protein sigma 1<br>Pfam-B_1003 (release 4.1). This family consists of the reovirus sigma 1 hemagglutinin, cell attachment protein. This glycoprotein is a minor capsid  protein and also determines the serotype-specific humoral immune response. Sigma 1 consist of a fibrous tail and a globular head. The head has important roles in the cell attachment function of sigma 1  and determinant of the type-specific humoral immune response  . Reovirus is part of the orthoreovirus group of retroviruses with, a dsRNA genome. Also present in this family is bacteriophage SF6  Lysozyme Swiss:P21270.. 
+PF04582 Reovirus sigma C capsid protein<br>Pfam-B_2922 (release 7.5). 
+PF00979 Reovirus outer capsid protein, Sigma 3<br>Pfam-B_1049 (release 3.0). Sigma 3 is the major outer capsid protein of reovirus  . Sigma 3 is encoded by genome segment 4.  Sigma 3 binds to  double stranded RNA and associates with polypeptide u1 and  its cleavage product u1C to form the outer shell of the virion. The Sigma 3 protein possesses a zinc-finger motif and an RNA-binding domain in the N and C termini respectively. This protein is also thought to play a role in pathogenesis.  . 
+PF01446 Rep; <br>Prodom_1565 (release 99.1). Replication proteins (rep) are involved in plasmid replication. The Rep protein binds to the plasmid DNA and nicks it at the double strand origin  (dso) of replication.  The 3'-hydroxyl end created is extended by the host DNA replicase, and the 5' end is displaced during synthesis. At the end of one replication round, Rep introduces a second single stranded break at the dso and ligates the ssDNA extremities generating one double-stranded plasmid and one circular ssDNA form. Complementary strand synthesis of the circular ssDNA is usually initiated at the single-stranded origin by the host RNA polymerase  .. 
+PF04057 Rep-A_protein_1;<br>Replication factor-A protein 1, N-terminal domain. Pfam-B_6000 (release 7.3);. 
+PF01719 Plasmid replication protein<br>Pfam-B_1901 (release 4.1). This family consists of various bacterial plasmid replication (Rep)  proteins. These proteins are essential for replication of plasmids, the Rep proteins are topoisomerases that nick the positive stand at the plus origin of replication and also at the single-strand conversion sequence  .. 
+PF01051 RepB_protein; <br>Initiator Replication protein. Pfam-B_313 (release 3.0). This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene [3,4].. 
+PF02486 Replication initiation factor<br>Pfam-B_2164 (release 5.4) & COG2946. Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a  sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family,  including myelin transcription factor 2 (Swiss:O15150) and cerebrin-50 (Swiss:Q16301)  .. 
+PF04796 Plasmid encoded RepA protein<br>Pfam-B_6223 (release 7.5). Family of plasmid encoded proteins involved in plasmid replication.  The role of RepA in the replication process is not clearly understood  .. 
+PF01421 Reprolysin (M12B) family zinc metalloprotease <br>The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.  Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin Swiss:Q28472.  Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.. 
+PF05140 ResB-like family <br>Pfam-B_1866 (release 7.7). This family includes both ResB and cytochrome c biogenesis  proteins [1,2].  Mutations in ResB indicate that they are  essential for growth  .  ResB is predicted to be a  transmembrane protein  .. 
+PF04851 Type III restriction enzyme, res subunit<br>Pfam-B_4631 (release 7.6). 
+PF00239 recombinase; resolvase; <br>Resolvase, N terminal domain. Prosite & Pfam-B_3830 (Release 7.5). The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface.  The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see Pfam:PF02796.. 
+PF00072 response_reg; <br>Response regulator receiver domain. This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.. 
+PF02813 Retroviral M domain<br>Retroviruses contain a small protein, MA (matrix), which forms a protein lining immediately beneath the phospholipid membrane of the mature virus particle. MA is located in the N-terminal region of the Gag precursor polyprotein. The N-terminal segment of MA proteins directs the Gag protein to the plasma membrane where budding takes place, and has been called the M domain.  This domain forms an alpha helical bundle structure.. 
+PF00424 REV protein (anti-repression trans-activator protein)<br>Pfam-B_169 (release 1.0). 
+PF00472 RF-1 domain<br>This domain is found in peptide chain release factors such as RF-1 (Swiss:P07011) and RF-2 (Swiss:P07012), and a number of smaller proteins of unknown function such as Swiss:P40711. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.. 
+PF04506 Rft protein<br>
+PF04589 RFX1 transcription activation region      <br>The RFX family is a family of winged-helix DNA binding proteins.  RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region  (Pfam:PF02257) in some mammalian RFX proteins, and is thought to activate  transcription when associated with DNA.  Deletion analysis has identified  the region 233-351 in human RFX1 (Swiss:P22670) as being required for  maximal activation  .. 
+PF02257 RFX DNA-binding domain<br>Pfam-B_3682 (release 5.2). RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer  . It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD)  .. 
+PF03214 Reversibly glycosylated polypeptide<br>Pfam-B_2662 (release 6.5). 
+PF05045 Rhamnan synthesis protein F<br>Pfam-B_5448 (release 7.7). This family consists of a group of proteins which are related to the Streptococcus rhamnose-glucose polysaccharide assembly protein (RgpF). Rhamnan backbones are found in several O polysaccharides of phytopathogenic bacteria and are regarded as pathogenic factors  .. 
+PF00615 Regulator of G protein signaling domain<br>Ponting C, Schultz J, Bork P. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.. 
+PF00974 Rhabd_glycop;<br>Rhabdovirus spike glycoprotein. Pfam-B_167 (release 3.0). Frequently abbreviated to G protein.  The glycoprotein spike is made up of a trimer of G proteins. Channel formed by glycoprotein spike is thought to function in a similar manner to Influenza virus M2 protein channel, thus allowing a signal to pass across the viral membrane to signal for viral uncoating.. 
+PF03342 Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)<br>Pfam-B_3629 (release 6.5). 
+PF04785 Rhabdovirus matrix protein M2<br>Pfam-B_2486 (release 7.6). M protein is involved in condensing and targeting the ribonucleoprotein (RNP) coil to the plasma membrane.  M interacts specifically with the transmembrane spike protein (G) is important for the incorporation of G  protein into budding virions  .. 
+PF03397 Rhabdovirus matrix protein<br>Pfam-B_3980 (release 6.6). 
+PF00945 Rhabd_nucleocap;<br>Rhabdovirus nucleocapsid protein. Pfam-B_477 (release 3.0). The Nucleocapsid (N) Protein is said to have a "tight" structure. The carboxyl end of the N-terminal domain possesses an RNA binding domain. Sequence alignments show 2 regions of reasonable conservation,  approx. 64-103 and 201-329  .  A whole functional protein is required  for encapsidation to take place  .. 
+PF03216 Rhabdovirus nucleoprotein<br>Pfam-B_2146 (release 6.5). 
+PF02484 Rhabd_NV; <br>Rhabdovirus Non-virion protein. Pfam-B_2189 (release 5.4). Infectious hematopoietic necrosis virus (IHNV) is a member of the family Rhabdoviridae. The non-virion protein (NV) is coded for by one of the six genes of the IHNV genome  , but is absent in vesiculovirus -like rhabdovirus  .. 
+PF00554 Rel homology domain (RHD)<br>Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF01833) that binds to DNA.. 
+PF02115 RHO protein GDP dissociation inhibitor<br>
+PF00581 Rhodanese-like domain<br>MRC-LMB Genome group. Rhodanese has an internal duplication.  This Pfam represents a single copy of this duplicated domain.  The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.. 
+PF00620 RhoGAP domain<br>Ponting C, Schultz J, Bork P. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.. 
+PF00621 RhoGEF domain<br>Alignment kindly provided by SMART. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.. 
+PF03527 RHS protein<br>
+PF00073 rhv; <br>picornavirus capsid protein. Overington and HMM_iterative_training. CAUTION: This alignment is very weak.  It can not be generated by clustalw. If a representative set is used for a seed, many so-called members are not recognised.  The family should probably be split up into sub-families. Capsid proteins of picornaviruses. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids. They include rhinovirus (common cold) and poliovirus. Common structure is an 8-stranded beta sandwich. Variations (one or two extra strands) occur.. 
+PF02267 ADP-ribosyl cyclase<br>Pfam-B_3719 (release 5.2). ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose  hydrolase or CD38) synthesises cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.. 
+PF01872 RibD C-terminal domain<br>Enright A & Pfam-B_6425 (Release 8.0). The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C terminus of RibD/RibG Swiss:P25539, in combination with Pfam:PF00383, as well as in isolation in some archaebacterial proteins Swiss:P95872.  This family appears to be related to Pfam:PF00186.. 
+PF05062 RICH domain<br>Pfam-B_277 (release 7.7). This presumed domain is about 85 residues in length and very rich in charged residues, hence the name RICH (Rich In CHarged residues). It is found in secreted proteins such as PspC Swiss:Q9KK19, SpsA Swiss:O33742 and IgA FC receptor Swiss:P27951 from Streptococcus agalactiae. This domain could be involved in bacterial adherence or cell wall binding.. 
+PF01042 DUF10;UPF0076; ribonuc_L-PSP; <br>Endoribonuclease L-PSP. Pfam-B_797 (release 3.0). Endoribonuclease active on single-stranded mRNA.  Inhibits protein synthesis by cleavage of mRNA  .  Previously thought to inhibit protein synthesis initiation  . This protein may also be involved in the regulation of purine biosynthesis  . YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase  . YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella  .. 
+PF00317 ribonucleo_red; ribonuc_red_lg; <br>Ribonucleotide reductase, all-alpha domain. 
+PF02867 ribonuc_red_lgC; <br>Ribonucleotide reductase, barrel domain. 
+PF00268 ribonuc_red; ribonuc_red_sm; <br>Ribonucleotide reductase, small chain. 
+PF00545 ribonuclease; <br>This enzyme hydrolyses RNA and oligoribonucleotides.. 
+PF03631 Ribonuclease_BN;<br>Virulence factor BrkB. Pfam-B_4424 (release 7.0). This family acts as a virulence factor. In Bordetella pertussis, Swiss:Q45339 is essential for resistance to complement-dependent killing by serum  . This family was originally predicted to be ribonuclease BN  , but this prediction has since been shown to be incorrect  .. 
+PF00825 Ribonuclease P<br>Pfam-B_1558 (release 2.1). 
+PF00445 ribonuclease_T2; <br>Ribonuclease T2 family. 
+PF00687 L1; <br>Ribosomal protein L1p/L10e family. Pfam-B_115 (release 2.1). This family includes prokaryotic L1 and eukaryotic L10.. 
+PF00466 L10;<br>Ribosomal protein L10. 
+PF00298 L11; <br>Ribosomal protein L11, RNA binding domain. 
+PF03946 L11; <br>Ribosomal protein L11, N-terminal domain. The N-terminal domain of Ribosomal protein L11 adopts an  alpha/beta fold and is followed by the RNA binding C-terminal domain.. 
+PF00542 L12; <br>Ribosomal protein L7/L12 C-terminal domain. 
+PF00572 L13;<br>Ribosomal protein L13. 
+PF01294 Ribosomal protein L13e<br>
+PF00238 L14; <br>Ribosomal protein L14p/L23e. 
+PF01929 Ribosomal protein L14<br>This family includes the eukaryotic ribosomal protein L14.. 
+PF00827 Ribosomal L15<br>Pfam-B_1567 (release 2.1). 
+PF00252 L16;<br>Ribosomal protein L16p/L10e. 
+PF01196 Ribosomal protein L17<br>
+PF00861 Ribosomal L18p/L5e family<br>Pfam-B_495 (release 3.0) & Pfam-B_741 (release 4.1). This family includes ribosomal proteins from the large subunit. This family includes L18 from bacteria and L5 from eukaryotes. It has been shown that the amino terminal 93 amino acids of Swiss:P09895 are necessary and sufficient to bind 5S rRNA in vitro  . Suggesting that the entire family has a function in rRNA binding.. 
+PF01245 Ribosomal protein L19<br>
+PF01280 Ribosomal protein L19e<br>
+PF00181 L2;<br>Ribosomal Proteins L2, RNA binding domain. 
+PF00453 L20;<br>Ribosomal protein L20. 
+PF01157 L21e;<br>Ribosomal protein L21e. 
+PF00829 Ribosomal prokaryotic L21 protein<br>Pfam-B_1297 (release 2.1). 
+PF00237 L22; <br>Ribosomal protein L22p/L17e. This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.. 
+PF01776 Ribosomal L22e protein family<br>
+PF00276 L23;<br>Ribosomal protein L23. 
+PF03939 Ribosomal protein L23, N-terminal domain<br>The N-terminal domain appears to be specific to the  eukaryotic ribosomal proteins L25, L23, and L23a.. 
+PF01246 Ribosomal protein L24e<br>
+PF01386 Ribosomal L25p family<br>Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis Swiss:P14194, which is induced by stress.. 
+PF01016 Ribosomal L27 protein<br>Pfam-B_1340 (release 3.0). 
+PF01777 Ribosomal L27e protein family<br>The N-terminal region of the eukaryotic ribosomal L27 has the KOW motif.  C-terminal region is represented by this family. . 
+PF00830 Ribosomal L28 family<br>Pfam-B_1561 (release 2.1). The ribosomal 28 family includes L28 proteins from bacteria and chloroplasts.  The L24 protein from yeast Swiss:P36525 also contains a region of similarity to prokaryotic L28 proteins.  L24 from yeast is also found in the large ribosomal subunit. 
+PF01778 Ribosomal L28e protein family<br>
+PF00831 Ribosomal L29 protein<br>Pfam-B_1296 (release 2.1). 
+PF01779 Ribosomal L29e protein family<br>
+PF03947 L2;<br>Ribosomal Proteins L2, C-terminal domain. 
+PF00297 L3;<br>Ribosomal protein L3. 
+PF00327 L30;<br>Ribosomal protein L30p/L7e. This family includes prokaryotic L30 and eukaryotic L7.. 
+PF01197 Ribosomal protein L31<br>
+PF01198 Ribosomal protein L31e<br>
+PF01655 Ribosomal protein L32<br>Pfam-B_1346 (release 4.1). This family includes ribosomal protein L32 from eukaryotes and archaebacteria.. 
+PF01783 Ribosomal L32p protein family<br>
+PF00471 L33; <br>Ribosomal protein L33. 
+PF00468 L34; <br>Ribosomal protein L34. 
+PF01199 Ribosomal protein L34e<br>
+PF01247 Ribosomal protein L35Ae<br>
+PF01632 Ribosomal protein L35<br>Pfam-B_1156 (release 4.1). 
+PF00444 L36;<br>Ribosomal protein L36. 
+PF01158 L36e; <br>Ribosomal protein L36e. 
+PF01780 Ribosomal L37ae protein family<br>This ribosomal protein is found in archaebacteria and eukaryotes. It contains four conserved cysteine residues that may bind to zinc.. 
+PF01781 Ribosomal L38e protein family<br>
+PF00832 Ribosomal L39 protein<br>Pfam-B_1293 (release 2.1). 
+PF00573 L1e; Ribosomal_L1e;<br>Ribosomal protein L4/L1 family. This family includes Ribosomal L4/L1 from eukaryotes and archaebacteria and L4 from eubacteria. L4 from yeast has been shown to bind rRNA  .. 
+PF01020 Ribosomal L40e family<br>Pfam-B_884 (release 3.0). Bovine L40 has been identified as a secondary RNA binding protein  . L40 is fused to a ubiquitin protein  .. 
+PF05162 Ribosomal protein L41<br>
+PF00935 L44;<br>Ribosomal protein L44. Pfam-B_1065 (release 3.0). 
+PF00281 L5;<br>Ribosomal protein L5. 
+PF00673 L5_C;<br>ribosomal L5P family C-terminus. Pfam-B_69 (release 2.1). This region is found associated with Pfam:PF00281.. 
+PF01159 L6e; <br>Ribosomal protein L6e . 
+PF03868 Ribosomal protein L6, N-terminal domain<br>
+PF01248 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family<br>This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118  .. 
+PF03948 Ribosomal protein L9, C-terminal domain<br>
+PF01281 Ribosomal_L9; <br>Ribosomal protein L9, N-terminal domain. 
+PF00338 S10;<br>Ribosomal protein S10p/S20e. This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.. 
+PF00411 S11;<br>Ribosomal protein S11. 
+PF00164 S12; Ribosomal_S12;<br>Ribosomal protein S12/S23. This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.. 
+PF00416 S13;<br>Ribosomal protein S13/S18. This family includes ribosomal protein S13 from prokaryotes and S18 from eukaryotes.. 
+PF00253 S14;<br>Ribosomal protein S14p/S29e. This family includes both ribosomal S14 from prokaryotes and S29 from eukaryotes.. 
+PF00312 S15; <br>Ribosomal protein S15. 
+PF00886 Ribosomal protein S16<br>Pfam-B_1025 (release 3.0). 
+PF00366 S17; <br>Ribosomal protein S17. 
+PF00833 Ribosomal_S17; <br>Pfam-B_1566 (release 2.1). 
+PF01084 S18;<br>Ribosomal protein S18. Pfam-B_712 (release 3.0). 
+PF00203 S19;<br>Ribosomal protein S19. 
+PF01090 S19e; <br>Ribosomal protein S19e. 
+PF00318 S2;<br>Ribosomal protein S2. 
+PF01649 Ribosomal protein S20<br>Pfam-B_1685 (release 4.1). Bacterial ribosomal protein S20 interacts with 16S rRNA  .. 
+PF01165 S21; <br>Ribosomal protein S21. 
+PF01249 Ribosomal protein S21e <br>
+PF01282 Ribosomal protein S24e<br>
+PF03297 S25 ribosomal protein<br>Pfam-B_4038 (release 6.5). 
+PF01283 Ribosomal protein S26e<br>
+PF01599 Ribosomal protein S27a<br>Pfam-B_638 (release 4.1). This family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins as extensions of ubiquitin promotes their incorporation into nascent ribosomes by a transient metabolic stabilisation and is required for efficient ribosome biogenesis  .  The ribosomal extension protein S27a contains a basic region that is proposed to form a zinc finger; its fusion gene is proposed as a mechanism to maintain a fixed ratio between ubiquitin necessary for degrading proteins and ribosomes a source of proteins  .. 
+PF01667 Ribosomal protein S27<br>Pfam-B_1929 (release 4.1). 
+PF01200 Ribosomal protein S28e<br>
+PF04758 Ribosomal protein S30<br>
+PF00189 S3_C;<br>Ribosomal protein S3, C-terminal domain. This family contains a central domain Pfam:PF00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain.\.   Some are much longer.. 
+PF01015 Ribosomal S3Ae family<br>Pfam-B_1334 (release 3.0). 
+PF00163 S4;<br>Ribosomal protein S4/S9 N-terminal domain. This family includes small ribosomal subunit S9 from prokaryotes and S16 from metazoans.  This domain is predicted to bind to ribosomal RNA  .  This domain is composed of four helices in the known structure.  However the domain is discontinuous in sequence and the alignment for this family contains only the first three helices.. 
+PF00900 Ribosomal family S4e<br>Pfam-B_1205 (release 3.0). 
+PF00333 S5; <br>Ribosomal protein S5, N-terminal domain. 
+PF03719 Ribosomal protein S5, C-terminal domain<br>
+PF01250 Ribosomal protein S6<br>
+PF01092 S6e; <br>Ribosomal protein S6e. 
+PF00177 S7; <br>Ribosomal protein S7p/S5e. This family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.. 
+PF01251 Ribosomal protein S7e<br>
+PF00410 S8; <br>Ribosomal protein S8. 
+PF00380 S9;<br>Ribosomal protein S9/S16. This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.. 
+PF00834 Ribulose-phosphate 3 epimerase family<br>Pfam-B_1291 (release 2.1). This enzyme catalyses the conversion of D-ribulose 5-phosphate into D-xylulose 5-phosphate.. 
+PF02009 Rifin/stevor family<br>Several multicopy gene families have been described in Plasmodium falciparum, including the stevor family of subtelomeric open reading frames and the rif interspersed repetitive elements. Both families contain three predicted transmembrane segments. It has been proposed that stevor and rif are members of a larger superfamily that code for variant surface antigens  .. 
+PF02197 Regulatory subunit of type II PKA R-subunit<br>Alignment kindly provided by SMART. 
+PF01782 RimM N-terminal domain<br>The RimM protein is essential for efficient processing of 16S rRNA  . The RimM protein was shown to have affinity for free ribosomal 30S subunits but not for 30S subunits in the 70S ribosomes  .  This N-terminal domain is found associated with a PRC-barrel domain  . . 
+PF00848 Ring hydroxylating alpha subunit (catalytic domain)<br>Pfam-B_407 (release 3.0). This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems.  The active site contains a non-heme ferrous ion coordinated by three ligands.. 
+PF00161 Ribosome inactivating protein<br>
+PF04957 Ribosome modulation factor<br>This protein associates with 70s ribosomes and converts them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells.. 
+PF04321 RmlD substrate binding domain<br>L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesised by four different enzymes the final one of which is RmlD.\.    The RmlD substrate binding domain is responsible for binding a sugar nucleotide [1,2].. 
+PF03035 Calicivirus putative RNA polymerase/capsid protein<br>Pfam-B_1282 (release 6.4). 
+PF00680 RNA dependent RNA polymerase<br>Pfam-B_32 (release 2.1). 
+PF00978 RNA_dep_RNApol2; <br>RNA dependent RNA polymerase. Pfam-B_13 (release 3.0). This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins:     2A protein from bromoviruses     putative RNA dependent RNA polymerase from tobamoviruses     Non structural polyprotein from togaviruses. 
+PF00910 RNA helicase<br>Pfam-B_11 (release 3.0). This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.. 
+PF00940 DNA-dependent RNA polymerase<br>Pfam-B_1108 (release 3.0). This is a family of single chain RNA polymerases.. 
+PF03118 Bacterial RNA polymerase, alpha chain C terminal domain<br>Pfam-B_172 (release 3.0). The alpha subunit of RNA polymerase consists of two independently folded domains, referred to as amino-terminal and carboxyl terminal domains.  The amino terminal domain is involved in the interaction with the other subunits of the RNA polymerase.  The carboxyl-terminal domain interacts with the DNA and activators.  The amino acid sequence of the alpha subunit is conserved in prokaryotic and chloroplast RNA  polymerases.  There are three regions of particularly strong  conservation, two in the amino-terminal and one in the carboxyl- terminal  .. 
+PF05066 RNA_pol_delta;<br>HB1, ASXL, restriction endonuclease HTH domain. A winged helix-turn-helix domain present in the plant HB1, vertebrate ASXL, the H. pylori restriction endonuclease HpyAIII(HgrA), the RNA polymerase delta subunit(RpoE) of Gram positive bacteria and several restriction endonucleases  . The domain is distinguished by the presence of a conserved one-turn helix between helix-3 and the preceding conserved turn. Its diverse architectures in eukaryotic species with extensive gene body methylation is suggestive of a chromatin function. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as  hmC  . Bacterial versions include fusions to diverse restriction  endonucleases, and a DNA glycosylase where it may play a similar  role in detecting modified DNA. Certain bacterial version of the  HARE-HTH domain show fusions to the helix-hairpin-helix domain of  the RNA polymerase alpha subunit and the HTH domains found in  regions 3 and 4 of the sigma factors  . These versions are  predicted to function as a novel inhibitor of the binding of RNA  polymerase to transcription start sites, similar to the Bacillus delta protein [2,3].. 
+PF04090 RNA polymerase I specific initiation factor<br>Pfam-B_43469 (release 7.3);. 
+PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain<br>Pfam-B_172 (release 3.0). The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer.  The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000).  Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037).  Rpb11 is found as a continuous domain.  Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.. 
+PF02150 RNA polymerases M/15 Kd subunit<br>
+PF01194 RNA polymerases N / 8 kDa subunit<br>
+PF04990 RNA polymerase Rpb1, domain 7<br>Pfam-B_288 (release 4.2). RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 forms a substantial interaction with the lobe domain of Rpb2 (Pfam:PF04561) [1,2].. 
+PF04563 RNA polymerase beta subunit<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure.  This domain is also known as the protrusion domain  .  The other lobe (Pfam:PF04561) is nested within this domain.. 
+PF04561 RNA polymerase Rpb2, domain 2<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure.  This domain is also known as the lobe domain  .  DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble  .  Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).. 
+PF04566 RNA polymerase Rpb2, domain 4<br>RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain  .. 
+PF01191 RNA_pol_H; <br>RNA polymerase Rpb5, C-terminal domain. The assembly domain of Rpb5  .  The archaeal equivalent to this domain is subunit H.  Subunit H lacks the N-terminal domain.. 
+PF03871 RNA polymerase Rpb5, N-terminal domain<br>Rpb5 has a bipartite structure which includes a eukaryote-specific  N-terminal domain and a C-terminal domain resembling the archaeal RNAP  subunit H [1,2].  The N-terminal domain is involved in DNA binding and is  part of the jaw module in the RNA pol II structure  .  This module is important for positioning the downstream DNA.. 
+PF01192 RNA polymerase Rpb6 <br>Rpb6 is an essential subunit in the eukaryotic polymerases Pol I, II and III. This family also contains the bacterial equivalent to Rpb6, the omega subunit.  Rpb6 and omega are structurally conserved and both function in polymerase assembly  .. 
+PF03876 RNA_pol_Rpb7_N;<br>SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397. Rpb7 bind to Rpb4 to form a heterodimer.  This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation .  This family includes the homologs from RNA polymerase I and III.  In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA  . The N terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction  .. 
+PF03870 RNA polymerase Rpb8<br>Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III.  Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.. 
+PF05158 RNA polymerase Rpc34 subunit<br>Subunit specific to RNA Pol III, the tRNA specific polymerase. The C34 subunit of yeast RNA Pol III is part of a subcomplex of  three subunits which have no counterpart in the other two nuclear RNA polymerases. This subunit interacts with TFIIIB70 and is  therefore participates in Pol III recruitment  . . 
+PF05132 RNA polymerase III RPC4<br>Pfam-B_18856 (release 7.7). Specific subunit for Pol III, the tRNA specific polymerase.. 
+PF03431 RNA replicase, beta-chain <br>Pfam-B_4422 (release 6.6). This family is of Leviviridae RNA replicases.  The replicase is also known as RNA dependent RNA polymerase.    . 
+PF01876 DUF53; <br>This protein is part of the RNase P complex that is involved in tRNA maturation  .. 
+PF01900 DUF69; <br>tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule associated with at least eight protein subunits, hPop1, Rpp14, Rpp20, Rpp25, Rpp29, Rpp30, Rpp38, and Rpp40  . This protein is known as Pop5 in eukaryotes.. 
+PF00074 rnaseA; <br>Pancreatic ribonuclease. Overington and HMM_iterative_training. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.. 
+PF00075 rnaseH; RnaseH;<br>Swissprot; SCOP and HMM_iterative_training. RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.. 
+PF00773 RNB domain<br>Pfam-B_1009 (release 2.1). This domain is the catalytic domain of ribonuclease II  .. 
+PF02508 Rnf-Nqr subunit, membrane protein<br>Pfam-B_1638 (release 5.4). This is a family of integral membrane proteins including  Rhodobacter-specific nitrogen fixation (rnf) proteins RnfA and RnfE   and Na+-translocating NADH:ubiquinone oxidoreductase  (Na+-NQR) subunits NqrD and NqrE. . 
+PF03259 Roadblock/LC7 domain<br>This family includes proteins that are about 100 amino acids long and have been shown to be related  . Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions  . This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility  . However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.. 
+PF00480 ROK family<br>
+PF02027 Glyco_hydro_41; <br>RolB/RolC glucosidase family. This family of proteins includes RolB and RolC.  RolC  releases cytokinins from glucoside conjugates  . Whereas RolB hydrolyses indole glucosides  .. 
+PF01815 Rop protein<br>
+PF00980 Rotavirus major capsid protein VP6<br>Pfam-B_1047 (release 3.0). Rotaviruses consist of three concentric protein shells.  The intermediate (middle) protein layer consists 260 trimers of VP6.  VP6 in the most  abundant protein in the virion.  VP6 is also involved in virion assembly, and possesses the ability to interact with VP2, VP4 and VP7 [1,2].. 
+PF01525 Rotavirus NS26<br>Pfam-B_762 (release 4.0). Gene 11 product is a non-structural phosphoprotein designated as NS26  .. 
+PF02509 Rotavirus non-structural protein 35<br>Pfam-B_1677 (release 5.4). Rotavirus non-structural protein 35 (NS35) is a basic protein which possesses RNA-binding activity and is essential for genome replication  .. 
+PF00981 Rotavirus RNA-binding Protein 53 (NS53)<br>Pfam-B_1048 (release 3.0). This protein is also known as NSP1. NS53 is encoded by gene 5.  It is made in low levels in the infected cells and is a component of early replication.  The protein is known to accumulate on the cytoskeleton of the infected cell.  NS53 is an RNA binding protein that contains a characteristic cysteine rich region  .. 
+PF04866 Rotavirus non-structural protein 6<br>Pfam-B_4831 (release 7.6). 
+PF01665 Rotavirus non-structural protein NSP3<br>Pfam-B_1010 (release 4.1). This family consist of rotaviral non-structural RNA binding protein 34 (NS34 or NSP3). The NSP3 protein has been shown to bind viral RNA.  The NSP3 protein consists of 3 conserved functional domains; a basic region which binds ssRNA, a region containing heptapeptide repeats mediating oligomerisation and a leucine zipper motif  . NSP3 may play a central role in replication and assembly of genomic RNA structures  . Rotaviruses have a dsRNA genome and are a major cause cause of acute gastroenteritis in the young of many species  . The rotavirus non-structural protein NSP3 is a sequence-specific RNA binding protein that binds the nonpolyadenylated 3' end of the rotavirus mRNAs. NSP3 also interacts with the translation initiation factor eIF4GI and competes with the poly(A) binding protein  .. 
+PF01452 Rotavirus non structural protein<br>Prodom_2202 (release 99.1). This protein has been called NSP4, NSP5, NS28, and NCVP5. The final steps in the assembly of rotavirus occur in the lumen of the endoplasmic reticulum (ER). Targeting of the immature inner capsid particle (ICP) to this compartment is mediated by the cytoplasmic tail of NSP4, located in the ER membrane.. 
+PF05087 Rotavirus VP2 protein<br>Pfam-B_6280 (release 7.7). Rotavirus particles consist of three concentric proteinaceous capsid layers. The innermost capsid (core) is made of VP2. The genomic RNA and the two minor proteins VP1 and VP3 are encapsidated within this layer  . The N-terminus of rotavirus VP2 is necessary for the encapsidation of VP1 and VP3  .. 
+PF00639 PPIC-type PPIASE domain<br>Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.. 
+PF03428 Replication protein C N-terminal domain<br>Pfam-B_4463 (release 6.6). Replication protein C is involved in the early stages of viral DNA replication.. 
+PF03055 Retinal pigment epithelial membrane protein<br>Pfam-B_947 (release 6.4). This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein.  The  family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.. 
+PF02318 RPH3A_effector; RPH3A_effect_N;<br>FYVE-type zinc finger. This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A   and regulating synaptic membrane exocytosis protein 2  .. 
+PF04390 DUF532; RplB;<br>Lipopolysaccharide-assembly. LptE (formerly known as RplB) is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported from its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptD appears to be anchored in the outer membrane, and LptE forms a complex with it. This part of the machinery complex is involved in the assembly of lipopolysaccharide in the outer leaflet of the outer membrane  .. 
+PF04032 DUF363; <br>RNAse P Rpr2/Rpp21/SNM1 subunit domain. This family contains a ribonuclease P subunit of humans and yeast.  Other members of the family include the probable archaeal homologues. This family includes SNM1  .  It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing.  SNM1 is an RNA binding protein that binds the MRP RNA specifically  . This subunit possibly binds the precursor tRNA  .. 
+PF01765 Ribosome recycling factor<br>Pfam-B_949 (release 4.2). The ribosome recycling factor (RRF / ribosome release factor) dissociates the ribosome from the mRNA after termination of translation, and is  essential bacterial growth  . Thus ribosomes are "recycled" and ready for another round of protein synthesis.. 
+PF00076 rrm; <br>RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). Published_alignment . The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.  The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.. 
+PF00398 Ribosomal RNA adenine dimethylase<br>
+PF04353 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ<br>This family includes bacterial transcriptional regulators that are thought to act through an interaction with the conserved region 4 of the sigma(70) subunit of RNA polymerase. The Pseudomonas aeruginosa homologue, AlgQ, positively regulates virulence gene expression and is associated with the mucoid phenotype observed in Pseudomonas aeruginosa isolates from cystic fibrosis patients.. 
+PF03873 Anti sigma-E protein RseA, C-terminal domain<br>Sigma-E is important for the induction of proteins  involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and  preventing transcription from heat-shock promoters  . The C-terminal domain is located in the periplasm, and may interact with other protein that signal  periplasmic stress.. 
+PF03872 Anti sigma-E protein RseA, N-terminal domain<br>Sigma-E is important for the induction of proteins  involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and  preventing transcription from heat-shock promoters  . The C-terminal domain is located in the periplasm, and may interact with other protein that signal  periplasmic stress.. 
+PF04246 Positive regulator of sigma(E), RseC/MucC<br>This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions)  . In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium  . In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain Pfam:PF02424, which is itself involved in thiamine biosynthesis. . 
+PF03113 Respiratory synctial virus non-structural protein NS2<br>Pfam-B_2717 (release 6.5). The molecular structure and function of the NS2 protein is not known. However, mutants lacking the NS2 grow at slower rates when compared to the wild-type. Nevertheless, NS2 is not essential for viral replication  .. 
+PF04479 RTA1 like protein<br>This family is comprised of fungal proteins with multiple transmembrane regions.  RTA1 (Swiss:P53047) is involved in resistance to 7-aminocholesterol  , while RTM1 (Swiss:P40113) confers resistance to an an unknown toxic chemical in molasses  .  These proteins may bind to the toxic substance, and thus prevent toxicity.  They are not thought to be involved in the efflux of xenobiotics  .. 
+PF02334 Replication terminator protein<br>Pfam-B_12997 (release 5.2). The bacterial replication terminator protein (RTP) plays a role in  the termination of DNA replication by impeding replication fork movement. Two RTP dimers bind to the two inverted repeat regions at the termination site.. 
+PF02382 RTX N-terminal domain<br>Pfam-B_833 (release 5.2). The RTX family of bacterial toxins are a group of cytolysins and cytotoxins. This Pfam family represents the N-terminal domain which is found in association with a glycine-rich repeat domain and  hemolysinCabind Pfam:PF00353.. 
+PF00016 Ribulose bisphosphate carboxylase large chain, catalytic domain<br>The C-terminal domain of RuBisCO large chain is the catalytic domain adopting a TIM barrel fold.. 
+PF02788 Ribulose bisphosphate carboxylase large chain, N-terminal domain<br>The N-terminal domain of RuBisCO large chain adopts a  ferredoxin-like fold.. 
+PF00101 Ribulose bisphosphate carboxylase, small chain<br>
+PF02915 Rubrerythrin<br>This domain has a ferritin-like fold.. 
+PF01330 RuvA; <br>RuvA N terminal domain. The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts  .. 
+PF02075 Crossover junction endodeoxyribonuclease RuvC<br>
+PF02042 RWP-RK domain<br>Pfam-B_9740 (Release 5.1). This domain is named RWP-RK after a conserved motif at the C terminus of the presumed domain. The domain is found in algal minus dominance proteins as well as plant proteins involved in nitrogen-controlled development  .. 
+PF01365 RIH domain<br>Ponting CP (EMBL alignments). The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels.  This region is found in the ryanodine receptor Swiss:P21817 and the inositol-1,4,5- trisphosphate receptor Swiss:Q14571. This domain may form a binding site for IP3  .. 
+PF02026 RyR domain<br>This domain is called RyR for Ryanodine receptor  . The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.. 
+PF00575 S1 RNA binding domain<br>The S1 domain occurs in a wide range of RNA associated proteins.  It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.. 
+PF00438 S-AdoMet_synt; <br>S-adenosylmethionine synthetase, N-terminal domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.. 
+PF02772 S-AdoMet_syntD2; <br>S-adenosylmethionine synthetase, central domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.. 
+PF02773 S-AdoMet_syntD3; <br>S-adenosylmethionine synthetase, C-terminal domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.. 
+PF02574 Homocysteine S-methyltransferase<br>This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases  also known EC:2.1.1.13,  ; Betaine--homocysteine S-methyltransferase  (vitamin B12 dependent), EC:2.1.1.5,  ; and Homocysteine  S-methyltransferase, EC:2.1.1.10,  .. 
+PF04689 DNA binding protein S1FA<br>S1FA is a DNA-binding protein found in plants that specifically  recognises the negative promoter element S1F  .. 
+PF05116 Sucrose-6F-phosphate phosphohydrolase<br>Pfam-B_6442 (release 7.7). This family consists of Sucrose-6F-phosphate phosphohydrolase proteins found in plants and cyanobacteria. Sucrose-6(F)-phosphate phosphohydrolase catalyses the final step in the pathway of sucrose biosynthesis  .. 
+PF01023 S_100_domain; <br>S-100/ICaBP type calcium binding domain. Pfam-B_242 (release 3.0). The S-100 domain is a subfamily of the EF-hand calcium binding proteins.. 
+PF05124 S-layer like family, C-terminal region <br>TIGRFAMs (release 2.0);. 
+PF05123 S-layer like family, N-terminal region <br>TIGRFAMs (release 2.0);. 
+PF00954 S-locus glycoprotein family<br>Pfam-B_357 (release 3.0). In Brassicaceae, self-incompatible plants have a self/non-self  recognition system.  This is sporophytically controlled by  multiple alleles at a single locus (S). S-locus glycoproteins, as well as S-receptor kinases, are in linkage with the S-alleles  .. 
+PF00526 S_mold_repeat; <br>Dictyostelium (slime mold) repeat. Pfam-B_96 (release 1.0). 
+PF00277 SAA_proteins; <br>Serum amyloid A protein. 
+PF04455 LOR/SDH bifunctional enzyme conserved region <br>Lysine-oxoglutarate reductase/Saccharopine dehydrogenase (LOR/SDH) is a bifunctional enzyme.  This conserved region is commonly found immediately  N-terminal to Saccharop_dh (Pfam:PF03435) in eukaryotes [1,2].. 
+PF04092 SRS domain<br>Pfam-B_1675 (release 7.3). Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. SAG1 is composed of two disulphide linked SRS domains. These have 6 cysteines that form 1-6,2-5 and 3-4 pairings. The structure of the immunodominant SAG1 antigen reveals a homodimeric configuration  . The SRS domain is found in a single copy in the SAG2 proteins. This family of surface antigens are found in other apicomplexans.. 
+PF01259 SAICAR synthetase<br>Pfam-B_1426 (release 3.0). Also known as Phosphoribosylaminoimidazole-succinocarboxamide  synthase.. 
+PF03534 Sal_SpvB; <br>Salmonella virulence plasmid 65kDa B protein. 
+PF03538 Sal_vir_VRP1; <br>Salmonella virulence plasmid 28.1kDa A protein. 
+PF01758 Sodium Bile acid symporter family<br>Pfam-B_697 (release 4.2). This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+  . Also in the family is ARC3 from S. cerevisiae Swiss:Q06598 this is a putative transmembrane protein involved in resistance to arsenic compounds  .. 
+PF03536 Sal_vir_VRP3; <br>Salmonella virulence-associated 28kDa protein. 
+PF01536 Adenosylmethionine decarboxylase<br>Pfam-B_600 (release 4.0). This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes.  In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine  . The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.. 
+PF02199 SAPA; <br>Saposin A-type domain. Alignment kindly provided by SMART. 
+PF03058 Sar8.2 family<br>Pfam-B_2148 (release 6.4). Members of this family are found in Solanaceae plants, a taxonomic group (family) that includes pepper and tobacco plant species.  Synthesis of these proteins is induced by tobacco mosaic virus (TMV) and salicylic acid  ; indeed they are thought to be involved in the development of systemic acquired resistance (SAR) after an initial hypersensitive response to microbial infection [1,2]. SAR is characterised by long-lasting resistance to infection by a wide range of pathogens, extending to plant tissues distant from the initial infection site  .. 
+PF04790 sarcoglycan; <br>Sarcoglycan complex subunit protein. Pfam-B_6135 (release 7.5). The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle.\.   The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.  This family contains beta, gamma and delta members [1,2].. 
+PF03343 SART-1 family<br>Mifsud W, Mistry J, Wood V. Pfam-B_3690 (release 6.5). SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing   .  It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae  .  SART-1 is a known tumour antigen in a range of cancers recognised by T cells  .. 
+PF00269 Small, acid-soluble spore proteins, alpha/beta type<br>
+PF04259 Small, acid-soluble spore protein, gamma-type <br>TIGRFAMs (release 2.0);. The SASP family is a family of small, glutamine and asparagine-rich  peptides that store amino acids in the spores of Bacillus subtilis  and related bacteria. . 
+PF03898 Satellite_CP; <br>Satellite tobacco necrosis virus coat protein. 
+PF03110 SBP domain<br>Pfam-B_737 (release 6.5). SBP domains (for SQUAMOSA-pROMOTER BINDING PROTEIN) are found in plant proteins.  It is a sequence specific DNA-binding domain  . Members of family probably function as transcription factors involved in the control of early flower development  . The domain contains 10 conserved cysteine and histidine residues that probably are zinc ligands.. 
+PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle<br>The borders of this family are based on the PDBSum definitions of the domain edges for Swiss:P06202.. 
+PF03480 Bacterial extracellular solute-binding protein, family 7<br>Pfam-B_808 (release 7.0). This family of proteins is involved in binding extracellular solutes for transport across the bacterial cytoplasmic membrane. This family includes Swiss:P37735, a C4-dicarboxylate-binding protein   and the sialic acid-binding protein SiaP. The structure of the SiaP receptor has revealed an overall topology similar to ATP binding cassette ESR (extracytoplasmic solute receptors) proteins  .  Upon binding of sialic acid, SiaP undergoes domain closure about a hinge region and kinking of an alpha-helix hinge component  .. 
+PF01297 Lipoprotein_4; SBP_bac_9;<br>Periplasmic solute binding protein family. Pfam-B_1416 (release 3.0). This family includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum.. 
+PF04405 Domain of Unknown function (DUF542)  <br>This domain is always found in conjunction with the HHE domain (Pfam:PF03794) at the  N-terminus.. 
+PF02667 Short chain fatty acid transporter<br>This family consists of two sequences annotated as short chain fatty acid transporters, however, there are no references giving details of experimental characterisation of this function.. 
+PF04486 SchA/CurD like domain<br>Members of this family have only been identified in species of the Streptomyces genus.  Two family members are known to be part of gene clusters involved in the synthesis of polyketide-based spore pigments, homologous to clusters involved in the synthesis of polyketide antibiotics.  The function of this protein is unknown, but it has been speculated to contain a NAD(P) binding site  . Many of these proteins contain two copies of this presumed domain.. 
+PF02630 SCO1/SenC<br>This family is involved in  biogenesis of respiratory and  photosynthetic systems. SCO1 (Swiss:P23833) is required for a  post-translational step in the accumulation of subunits COXI and COXII of cytochrome c oxidase  . SenC (Swiss:Q52720) is required for optimal  cytochrome c oxidase activity and maximal induction of genes encoding the light-harvesting and reaction centre complexes of R. capsulatus  .  . 
+PF02036 SCP-2 sterol transfer family<br>Pfam-B_1050 (Release 5.1). This domain is involved in binding sterols. It is found in the SCP2 protein Swiss:P22307, as well as the C terminus of Swiss:P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Swiss:Q17372 contains an SPFH domain Pfam:PF01145  .  . 
+PF00375 Sodium:dicarboxylate symporter family<br>
+PF02982 Scytalone_DH; <br>Scytalone dehydratase. Scytalone dehydratases are structurally related to the NTF2 family (see Pfam:PF02136).. 
+PF03313 Serine dehydratase alpha chain<br>L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyses the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.. 
+PF03315 Serine dehydratase beta chain<br>L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyses the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.. 
+PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit<br>Prosite & Structural domain. This family includes a transmembrane protein from both the Succinate dehydrogenase and Fumarate reductase complexes.. 
+PF02810 SEC-C motif<br>The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the  CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.. 
+PF00995 Sec1 family<br>Pfam-B_530 (release 3.0). 
+PF03908 Sec20<br>Wood V, Griffiths-Jones SR. Sec20 is a membrane glycoprotein associated with secretory pathway.. 
+PF03911 Sec61beta family<br>This family consists of homologues of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG. It consists of a single putative transmembrane helix, preceded by a short stretch containing various charged residues; this arrangement may help determine orientation in the cell membrane  .. 
+PF03839 Translocation protein Sec62<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01369 Sec7 domain<br>Pfam-B_1629 (release 3.0). The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the Pfam:PF00025 family  .. 
+PF01043 SecA_protein; SecA;<br>SecA preprotein cross-linking domain. Pfam-B_507 (release 3.0). The SecA ATPase is involved in the insertion and retraction of preproteins through the plasma membrane.  This domain has been found to cross-link to preproteins, thought to  indicate a role in  preprotein binding.  The pre-protein cross-linking domain is comprised of two sub domains that are inserted within the ATPase domain  .  . 
+PF02556 Preprotein translocase subunit SecB<br>This family consists of preprotein translocase subunit SecB. SecB is required for the normal export of envelope proteins out of the  cell cytoplasm  .. 
+PF02355 Protein export membrane protein<br>Pfam-B_844 (release 5.2). This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC  . SecD and SecF are required to maintain a proton motive force  .. 
+PF00584 SecE/Sec61-gamma subunits of protein translocation complex<br>SecE is part of the SecYEG complex in bacteria which  translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha  translocates protein from the cytoplasm to the ER.  Archaea have a similar complex.. 
+PF03840 Preprotein translocase SecG subunit<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04856 Securin sister-chromatid separation inhibitor<br>Pfam-B_4643 (release 7.6). Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss  .. 
+PF00344 secY;<br>
+PF04628 Sedlin, N-terminal conserved region<br>Pfam-B_5308 (release 7.5). Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400)  . This family represents an N-terminal conserved region.. 
+PF00477 seed_protein; <br>Small hydrophilic plant seed protein. 
+PF03841 L-seryl-tRNA selenium transferase<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04593 Selenoprotein P, C terminal region<br>SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma  . It is thought to be glycosylated  . SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity  . The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage  . The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function  . The N terminal region always contains one Sec residue, and this is separated from the C terminal region (9-16 sec residues) by a histidine-rich sequence  .  The large number of Sec residues in the C-terminal portion of SelP suggest CC that it may be involved in selenium transport or storage. However, it is also possible that this region has a redox function  .. 
+PF04592 Selenoprotein P, N terminal region<br>SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma  .  It is thought to be glycosylated  .  SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity  . The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage  . The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function  . The N-terminal region of SelP can exist independently of the C terminal region.  Zebrafish selenoprotein Pb (Swiss:Q98SV0) lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported  . N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins.  It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions  . The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding.  Binding to heparan proteoglycans could account for the membrane binding properties of SelP  .  The function of the bacterial members of this family is uncharcterised.. 
+PF01641 DUF25;<br>Pfam-B_1539 (release 4.1). Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterised with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidised methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR , evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain Pfam:PF01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc  . The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family  . This family has methionine-R-sulfoxide reductase activity  .. 
+PF01403 Sema domain<br>The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance.  Sema domains also occur in Swiss:P08581 the hepatocyte growth factor receptor and Swiss:P51805. 
+PF01118 Semialdehyde dehydrogenase, NAD binding domain<br>Pfam-B_1079 (release 3.0). This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase. 
+PF02774 Semialdehyde dehydrogenase, dimerisation domain<br>Pfam-B_1079 (release 3.0). This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase. 
+PF03925 SeqA protein<br>The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation  . SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner  . Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor  .. 
+PF04360 Serglycin <br>Serglycin is the most prevalent proteoglycan produced in haemopoietic cells. Serglycin is a proteinase resistant secretory granule  proteoglycan  .. 
+PF00450 serine_carbpept; <br>Serine carboxypeptidase. 
+PF00079 serpin; <br>Serpin (serine protease inhibitor). Overington and HMM_iterative_training. Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.. 
+PF02403 Seryl-tRNA synthetase N-terminal domain<br>Pfam-B_518 (release 5.4). This domain is found associated with the Pfam tRNA synthetase class II domain (Pfam:PF00587) and represents the N-terminal domain of seryl-tRNA synthetase.. 
+PF01445 Viral small hydrophobic protein<br>Prodom_1504 (release 99.1). The SH (small hydrophobic) protein is a membrane protein of uncertain function  .. 
+PF00017 SH2 domain<br>Swissprot_feature_table. 
+PF00018 SH3;<br>SH3 (Src homology 3) domains are often indicative of a protein involved in  signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.. 
+PF04908 SH3-binding, glutamic acid-rich protein<br>Pfam-B_6650 (release 7.6). 
+PF03579 Small hydrophobic protein<br>Pfam-B_1121 (release 7.0). The small hydrophobic integral membrane protein, SH (previously designated 1A) is found to have a variety of glycosylated forms [1,2]. This protein is a component of the mature virion  .   . 
+PF01488 Shikimate / quinate 5-dehydrogenase<br>Pfam-B_336 (release 4.0). This family contains both shikimate and quinate dehydrogenases. Shikimate 5-dehydrogenase catalyses the conversion of  shikimate to 5-dehydroshikimate. This reaction is part of  the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Quinate 5-dehydrogenase catalyses the conversion of  quinate to 5-dehydroquinate. This reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes. Both the shikimate and quinate pathways share two common pathway metabolites 3-dehydroquinate and dehydroshikimate.. 
+PF00464 Serine hydroxymethyltransferase<br>
+PF04917 Bacterial shufflon protein, N-terminal constant region<br>Pfam-B_6667 (release 7.6). This family represents the high-similarity N-terminal 'constant region' shared by shufflon proteins.. 
+PF02973 sialidase_N; <br>Sialidase, N-terminal domain. 
+PF03482 sic; <br>Pfam-B_5 (Release 7.0). Serotype M1 group A Streptococcus strains cause epidemic waves of human infections. This family includes the sic protein an extracellular  protein (streptococcal inhibitor of complement) that inhibits human complement  .. 
+PF00158 sigma54;<br>Sigma-54 interaction domain. 
+PF00309 sigma54_AID; <br>Sigma-54 factor, Activator interacting domain (AID) . The sigma-54 holoenzyme is an enhancer dependent  form of the RNA polymerase.  The AID is necessary for activator interaction  .  In addition, the AID also inhibits  transcription initiation in the sigma-54 holoenzyme prior to  interaction with the activator  .. 
+PF04963 sigma54_CBD; <br>Sigma-54 factor, core binding domain. This domain makes a direct interaction with the core RNA polymerase, to form an enhancer dependent holoenzyme  . The centre of this domain contains a very weak similarity to a helix-turn-helix motif which may represent the other DNA binding domain.. 
+PF04552 sigma54_DBD; <br>Sigma-54, DNA binding domain. This DNA binding domain is based on peptide fragmentation data.  This domain is proximal to DNA in the promoter/holoenzyme complex.  Furthermore this region contains a putative helix-turn-helix motif.  At the C-terminus, there is a highly conserved region known as the RpoN box and is the signature of the sigma-54 proteins  . . 
+PF04546 sigma70_ner; <br>Sigma-70, non-essential region. The domain is found in the primary vegetative sigma factor.  The function of this domain is unclear and can be removed without loss of function.. 
+PF03979 sigma70_r1_1; <br>Sigma-70 factor, region 1.1. Region 1.1 modulates DNA binding by region 2 and 4 when sigma is unbound by the core RNA polymerase [1,2]. Region 1.1 is also involved in promoter binding  . 
+PF00140 sigma70_r1_2; <br>Sigma-70 factor, region 1.2. 
+PF04539 sigma70_r3; <br>Region 3 forms a discrete compact three helical domain within the sigma-factor.  Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role.  Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme  .. 
+PF03084 Reoviral Sigma1/Sigma2 family<br>Pfam-B_1759 (release 6.4). Reoviruses are double-stranded RNA viruses. They lack a membrane envelope and their capsid is organised in two concentric icosahedral layers: an inner core and an outer capsid layer. The sigma1 protein is found in the outer capsid, and the sigma2 protein is found in the core. There are four other kinds of protein (besides sigma2) in the core, termed lambda 1-3, mu2. Interactions between sigma2 and lambda 1 and lambda 3 are thought to initiate core formation, followed by mu2 and lambda2  . Sigma1 is a trimeric protein, and is positioned at the 12 vertices of the icosahedral outer capsid layer. Its N-terminal fibrous tail, arranged as a triple coiled coil, anchors it in the virion, and a C-terminal globular head interacts with the cellular receptor  .  These two parts form by separate trimerisation events. The N-terminal fibrous tail forms on the polysome, without the involvement of ATP or chaperones. The post- translational assembly of the C-terminal globular head involves the chaperone activity of Hsp90, which is associated with  phosphorylation of Hsp90 during the process  . Sigma1 protein acts as a cell attachment protein, and determines viral virulence, pathways of spread, and tropism. Junctional adhesion molecule has been identified as a receptor for sigma1  . In type 3  reoviruses, a small region, predicted to form a beta sheet, in the N-terminal tail was found to bind target cell surface sialic acid (i.e. sialic acid acts as a co-receptor) and promote apoptosis  . The sigma1 protein also binds to the lambda2 core protein  .. 
+PF02454 Sigma 1s protein<br>Pfam-B_2133 (release 5.4). The reoviral gene S1 encodes for haemagglutinin (sigma 1 protein), an outer capsid protein and a major factor in determining virus-host cell interactions. Sigma 1s is one of two translation products of the S1 gene.. 
+PF03842 Silicon transporter<br>TIGRFAMs, Griffiths-Jones SR. 
+PF04801 Sin-like protein conserved region<br>Pfam-B_6302 (release 7.5). Family of higher eukaryotic proteins.  SIN was identified as a protein that interacts specifically with SXL (sex lethal) in a yeast two-hybrid assay.\.   The interaction is mediated by one of the SXL RNA binding domains  .. 
+PF04954 Siderophore-interacting protein<br>
+PF02146 Sir2 family<br>This region is characteristic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organisation and DNA damage repair processes  .. 
+PF04247 Invasion gene expression up-regulator, SirB<br>SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown  .. 
+PF01380 SIS domain<br>SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.  Presumably the SIS domains bind to the end-product of the pathway.. 
+PF05185 Skb1; <br>PRMT5 arginine-N-methyltransferase. Pfam-B_4050 (release 7.7). The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase   .  These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.. 
+PF01202 Shikimate kinase<br>
+PF02731 SKIP/SNW domain<br>This domain is found in chromatin proteins.. 
+PF03217 Bacterial surface layer protein<br>Pfam-B_2530 (release 6.5). 
+PF03843 Outer membrane lipoprotein Slp family<br>TIGRFAMs, Griffiths-Jones SR. 
+PF01464 Transglycosylase SLT domain<br>Prodom_3175 (release 99.1). This family is distantly related to Pfam:PF00062. Members are found in phages, type II, type III and type IV secretion systems (reviewed in  ).. 
+PF02258 Shiga-like toxin beta subunit<br>Pfam-B_3684 (release 5.2). This family represents the B subunit of shiga-like toxin (SLT or verotoxin) produced by some strains of E.coli associated with hemorrhagic colitis and hemolytic uremic syndrome. SLT's are  composed of one enzymatic A subunit and five cell binding B subunits.. 
+PF04102 SlyX<br>The SlyX protein has no known function.  It is short less than 80 amino acids and is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C-terminus. The protein may be a coiled-coil structure.. 
+PF02481 SMF; <br>DNA recombination-mediator protein A. Pfam-B_2252 (release 5.4). The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation  . It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyse the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation  .. 
+PF03467 Smg-4/UPF3 family<br>This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4   and UPF3.. 
+PF04927 Seed maturation protein<br>Pfam-B_6221 (release 7.6). Plant seed maturation protein.. 
+PF04355 SmpA / OmlA family<br>Lipoprotein Bacterial outer membrane lipoprotein, possibly involved in in maintaining the structural integrity of the cell envelope  .  Lipid attachment site  is a conserved N terminal cysteine residue.  Sometimes found adjacent to  the OmpA domain (Pfam:PF00691).. 
+PF01668 SmpB protein<br>Pfam-B_1766 (release 4.1). 
+PF01713 Smr domain<br>This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 Swiss:P23909 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2 Swiss:P94545  . This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity  . The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity.. 
+PF00835 SNAP-25 family<br>Pfam-B_1606 (release 2.1). SNAP-25 (synaptosome-associated protein 25 kDa) proteins are components of SNARE complexes. Members of this family contain a cluster of cysteine residues that can be palmitoylated for membrane attachment  .. 
+PF00565 Staphylococcal nuclease homologue<br>Alignment kindly provided by SMART. Present in all three domains of cellular life. Four copies in the transcriptional coactivator p100: these, however, appear to lack the active site residues of Staphylococcal nuclease. Positions 14 (Asp-21), 34 (Arg-35), 39 (Asp-40), 42 (Glu-43) and 110 (Arg-87) [SNase numbering in parentheses] are thought to be involved in substrate-binding and catalysis.. 
+PF00209 Sodium:neurotransmitter symporter family<br>
+PF00176 SNF2 family N-terminal domain<br>This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).. 
+PF04855 SNF5 / SMARCB1 / INI1<br>Pfam-B_6054 (release 7.6). SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes  characterised so far  .  This family consists of the conserved region of SNF5, including a direct repeat motif.  SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF  complex  . SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs)  .. 
+PF01174 UPF0030; <br>SNO glutamine amidotransferase family. This family and its amidotransferase domain was first described in  . It is predicted that members of this family are involved in the pyridoxine biosynthetic pathway, based on the proximity and co-regulation of the corresponding genes and physical interaction between the members of Pfam:PF01174 and Pfam:PF01680  .. 
+PF00080 sodcu; <br>Copper/zinc superoxide dismutase (SODC). Overington and HMM_iterative_training. superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen.  Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding  family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.. 
+PF00081 sodfe; <br>Iron/manganese superoxide dismutases, alpha-hairpin domain. Eddy SR, Griffiths-Jones SR. Overington and HMM_iterative_training. superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen.  Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin.  A small fragment of YTRE_LEPBI matches well - sequencing error?. 
+PF02777 sodfe_C; <br>Iron/manganese superoxide dismutases, C-terminal domain. Eddy SR, Griffiths-Jones SR. Overington and HMM_iterative_training. superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.. 
+PF03002 Somatostatin/Cortistatin family<br>Pfam-B_1891 (release 6.4). Members of this family are hormones. Somatostatin inhibits the release of somatotropin. Cortistatin is a peptide that is related to the Somatostatins that is found to depresses neuronal electrical activity but, unlike somatostatin, induces low-frequency waves in the cerebral cortex and antagonises the effects of acetylcholine on hippocampal and cortical measures of excitability  .. 
+PF01680 UPF0019; <br>Pfam-B_2034 (release 4.1). Members of this family are enzymes involved in a new pathway of pyridoxine/pyridoxal 5-phosphate biosynthesis  . This family was formerly known as UPF0019.. 
+PF02208 Sorbin homologous domain<br>Alignment kindly provided by SMART. 
+PF04203 Sortase family<br>TIGRFAMs (release 2.0);. The founder member of this family is S.aureus sortase,  a transpeptidase that attaches surface proteins by the  threonine of an LPXTG motif to the cell wall  . . 
+PF04832 SOUL heme-binding protein<br>Pfam-B_3872 (release 7.6). This family represents a group of putative heme-binding proteins  . Our family includes archaeal and bacterial homologues.. 
+PF04267 Sarcosine oxidase, delta subunit family <br>TIGRFAMs (release 2.0);. Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+).  This enzyme catalyses the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2 [1,2].. 
+PF04268 Sarcosine oxidase, gamma subunit family <br>TIGRFAMs (release 2.0);. Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+).  This enzyme catalyses the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2 [1,2].. 
+PF03172 Sp100 domain<br>Pfam-B_3126 (release 6.5). The function of this domain is unknown.  It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND domain Pfam:PF01342.. 
+PF03014 Structural protein 2<br>Pfam-B_1375 (release 6.4). This family represents structural protein 2 of the hepatitis E virus. The high basic amino acid content of this protein has lead to  the suggestion of a role in viral genomic RNA encapsidation.. 
+PF02090 Salmonella surface presentation of antigen gene type M protein<br>
+PF02510 Surface presentation of antigens protein<br>Pfam-B_1678 (release 5.4). Surface presentation of antigens protein (SPAN), also know as invasion protein invJ, is a Salmonella secretory pathway protein involved in presentation of determinants required for mammalian host cell invasion. . 
+PF04573 Signal peptidase subunit<br>Pfam-B_4675 (release 7.5). Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals.  This family is common to yeast and mammals  [1,2].. 
+PF05122 Mobile element transfer protein<br>This proteins are involved in transferring a group of integrating conjugative DNA elements, such as pSAM2 from Streptomyces ambofaciens ( ). Their precise role is not known. . 
+PF03771 DUF317; <br>Domain of unknown function (DUF317). This a sequence family found in a set of bacterial proteins with no known function. This domain is currently only found in streptomyces bacteria.\.      Most proteins contain two copies of this domain.. 
+PF00435 spectrin; <br>Pfam-B_1 (release 1.0). Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure.  These include spectrin, alpha-actinin and dystrophin.  The sequence repeat used in this family is taken from the structural repeat in reference  . The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in ultiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.. 
+PF01564 Spermine/spermidine synthase<br>Pfam-B_798 (release 4.0). Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.. 
+PF02819 spidertoxin; <br>This family of spider neurotoxins are thought to be calcium ion channel inhibitors.. 
+PF02513 Spin/Ssty Family<br>Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo  . The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis  and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.. 
+PF05215 Spiralin<br>Pfam-B_6625 (release 7.7). This family consists of Spiralin proteins found in spiroplasma bacteria. Spiroplasmas are helically shaped pathogenic bacteria related to the  mycoplasmas. The surface of spiroplasma bacteria is crowded with the  membrane-anchored lipoprotein spiralin whose structure and function are  unknown although its cellular function is thought to be a structural and  mechanical one rather than a catalytic one  .. 
+PF03533 SPO11 homologue<br>
+PF05032 Spo12 family<br>Pfam-B_51047 (release 7.6). This family of proteins includes Spo12 from S. cerevisiae Swiss:P17123. The Spo12 protein plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive  . Spo12 is a nuclear protein  . Spo12 is a component of the FEAR (Cdc fourteen early anaphase release) regulatory network, that promotes Cdc14 release from the nucleolus during early anaphase  . The FEAR network is comprised of the polo kinase Cdc5, the separase Esp1, the kinetochore-associated protein Slk19, and Spo12  .. 
+PF03907 Spo7-like protein<br>S. cerevisiae Spo7 Swiss:P18410 has an unknown function, but has a role in formation of a spherical nucleus and meiotic division  .. 
+PF01052 SPOA_protein;<br>Surface presentation of antigens (SPOA). Pfam-B_408 (release 3.0). This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, Pfam:PF02154.. 
+PF05036 Sporulation related domain<br>This 70 residue domain is composed of two 35 residue repeats found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM.  This domain is involved in binding peptidoglycan  . Two tandem repeats fold into a pseudo-2-fold symmetric single-domain structure containing numerous contacts between the repeats  . FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats lay at the periplasmic C-terminus. FtsN localises to the septum ring complex.. 
+PF03845 Spore germination protein<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00588 SpoU rRNA Methylase family<br>MRC-LMB Genome group. This family of proteins probably use S-AdoMet. . 
+PF03862 spoVA;<br>Members of this family are all transcribed from the spoVA operon. These proteins are poorly characterised, but are thought to be involved in dipicolinic acid transport into the developing forespore during sporulation  .. 
+PF04026 SpoVG<br>Stage V sporulation protein G. Essential for sporulation and specific to stage V sporulation in Bacillus megaterium and subtilis  . In B. subtilis, expression decreases after 30-60 minutes of cold shock  .. 
+PF04293 SpoVR like protein<br>Family member Swiss:P37875 is Bacillus subtilis stage V sporulation protein R, which is involved in spore cortex formation  .  Little is known about cortex biosynthesis, except that it depends on several sigma E  controlled genes, including spoVR  .. 
+PF04232 Stage V sporulation protein S (SpoVS)<br>In Bacillus subtilis this protein interferes with sporulation at an early stage and this inhibitory effect is overcome by SpoIIB and SpoVG.  SpoVS seems to play a positive role in allowing progression beyond stage V of sporulation.  Null mutations in the spoVS gene block sporulation at stage V, impairing the development of heat resistance and coat assembly  .. 
+PF03539 Spumavirus aspartic protease (A9)<br>
+PF03779 SPW repeat<br>A short repeat found in a small family  of membrane-bound proteins. This repeat contains a conserved SPW motif in the first of two transmembrane helices.. 
+PF00494 Squalene/phytoene synthase<br>
+PF00299 squash; <br>Squash family serine protease inhibitor. 
+PF02117 Sra; 7TM_GCPR_Sra; <br>Serpentine type 7TM GPCR chemoreceptor Sra. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF02175 Srb; <br>Serpentine type 7TM GPCR chemoreceptor Srb. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srb is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF00530 Scavenger receptor cysteine-rich domain<br>These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.. 
+PF00319 transcript_fact; <br>SRF-type transcription factor (DNA-binding and dimerisation domain). Prosite & Pfam-B_6396 (Release 8.0). 
+PF02118 Srg family chemoreceptor<br>
+PF02290 Signal recognition particle 14kD protein<br>Pfam-B_7955 (release 5.2). The signal recognition particle (SRP) is a multimeric protein  involved in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP14 and SRP9 form a complex essential for  SRP RNA binding.. 
+PF01922 SRP19 protein<br>The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein   (Sec65 in yeast [2,3]).. 
+PF00660 Seripauperin and TIP1 family<br>
+PF05022 SRP40, C-terminal domain<br>Pfam-B_9034 (release 7.6). This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein Swiss:P32583 and its homologues. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.. 
+PF04888 Secretion system effector C (SseC) like family <br>Pfam-B_5525 (release 7.6). SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella.  All these proteins are secreted by the type III secretion system  . Many mucosal pathogens use type III secretion systems for the injection of effector proteins into target cells.  SecB, SseC and SecD are inserted into the target cell membrane.  where they form a small pore or translocon [1,2]. In addition to SseC, this family includes the bacterial secreted proteins PopB, PepB, YopB and EspD which are thought to be directly involved in pore formation, and type III secretion system translocon.. 
+PF00474 Sodium:solute symporter family<br>This family includes Swiss:P33413 which is not in the Prosite entry.  Membership of this family is supported by a significant blast score.. 
+PF04686 Streptomyces sporulation and cell division protein, SsgA<br>Pfam-B_5645 (release 7.5). The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division  .. 
+PF00720 Subtilisin inhibitor-like<br>Pfam-B_679 (release 2.1). 
+PF04056 Ssl1-like<br>Pfam-B_13499 (release 7.3);. Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex.. 
+PF04386 Stringent starvation protein B<br>Escherichia coli stringent starvation protein B (SspB), is thought to enhance the specificity of degradation of tmRNA-tagged proteins by the ClpXP protease.  The tmRNA tag, also known as ssrA, is an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP.  SspB a cytoplasmic protein that specifically binds to residues 1-4 and 7 of the tag. Binding of SspB enhances degradation of tagged proteins by ClpX, and masks sequence elements important for ClpA interactions, inhibiting degradation by ClpA  . However, more recent work has cast doubt on the importance of SspB in wild-type cells  . SspB is encoded in an operon whose synthesis is stimulated by carbon, amino acid, and phosphate starvation.  SspB may play a special role during nutrient stress, for example by ensuring rapid degradation of the products of stalled translation, without causing a global increase in degradation of all ClpXP substrates  .. 
+PF03531 Structure-specific recognition protein (SSRP1)<br>Griffiths-Jones SR, Mistry J. SSRP1 has been implicated in transcriptional initiation and elongation and in DNA replication and repair  . This domain belongs to the Pleckstrin homology fold superfamily.. 
+PF04722 Ssu72-like protein<br>Pfam-B_5993 (release 7.5). The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB  .  It binds to TFIIB and is also involved in mRNA elongation.  Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation.  Ssu72 is also essential for transcription termination of snRNAs   .. 
+PF04184 ST7 protein<br>Pfam-B_2088 (release 7.3). The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.. 
+PF03298 Stanniocalcin family<br>Pfam-B_4401 (release 6.5). 
+PF02200 STE like transcription factor<br>Alignment kindly provided by SMART. 
+PF02876 Staphylococcal/Streptococcal toxin, beta-grasp domain<br>
+PF01123 Staphylococcal/Streptococcal toxin, OB-fold domain<br>
+PF04022 Staphylocoagulase repeat<br>
+PF02821 Staphylokinase/Streptokinase family<br>
+PF01017 STAT; <br>STAT protein, all-alpha domain. Pfam-B_856 (release 3.0). STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.. 
+PF02864 STAT protein, DNA binding domain<br>Pfam-B_856 (release 3.0). STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain Pfam:PF00017.. 
+PF02865 STAT_prot; <br>STAT protein, protein interaction domain. Pfam-B_856 (release 3.0). STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.. 
+PF03875 Statherin<br>Statherin functions biologically to inhibit the  nucleation and growth of calcium phosphate minerals. The N-terminus of statherin is highly charge, the glutamic acids of which  have been shown to be  important in the recognition hydroxyapatite  . . 
+PF00836 Stathmin family<br>Pfam-B_1551 (release 2.1). The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton.  They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerisation of tubulin heterodimers  .. 
+PF02116 Fungal pheromone mating factor STE2 GPCR<br>
+PF02076 Pheromone A receptor<br>
+PF04885 Stigma-specific protein, Stig1<br>Pfam-B_6528 (release 7.6). This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone  .. 
+PF05217 STOP protein<br>Pfam-B_6629 (release 7.7). Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable  microtubules are thought to be essential for neuronal development, maintenance, and function. STOP is a major factor responsible for the  intriguing stability properties of neuronal microtubules and is important  for synaptic plasticity. Additionally knowledge of STOPs function and properties may help in the treatment of neuroleptics in illnesses such as schizophrenia, currently thought to result from synaptic defects  .. 
+PF03088 Strictosidine synthase<br>Pfam-B_1533 (release 6.5). Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid  biosynthesis.  It catalyses the condensation of tryptamine with  secologanin to form strictosidine.. 
+PF04270 strep_his_triad; <br>Streptococcal histidine triad protein . TIGRFAMs (release 2.0);. All members of this family are proteins from Streptococcal species.  The proteins are characterised by having a HxxHxH motif that usually occurs multiple times throughout the protein.. 
+PF02516 Oligosaccharyl transferase STT3 subunit<br>Pfam-B_1095 (release 5.4). This family consists of the oligosaccharyl transferase STT3 subunit and related proteins.  The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for its activity  .  In eukaryotes, OTase transfers a lipid-linked core-oligosaccharide to selected asparagine residues in the ER  . In the archaea STT3 occurs alone, rather than in an OTase complex, and is required for N-glycosylation of asparagines [3-4].. 
+PF03481 Putative GTP-binding controlling metal-binding<br>Structural investigation of this domain suggests that it might be a GTP-binding region that regulates metal binding and involves hydrolysis of ATP to AMP. It is found to the C-terminus of Pfam:PF01300.. 
+PF01300 Telomere recombination<br>This domain has been shown to bind preferentially to dsRNA  . The domain is found in SUA5 Swiss:P32579 as well as HypF and YrdC Swiss:P45748. It has also been shown to be required for telomere recombniation in yeast.. 
+PF00862 Sucrose synthase<br>Pfam-B_484 (release 3.0). Sucrose synthases catalyse the synthesis of sucrose from UDP-glucose and fructose. This family includes the bulk of the sucrose synthase protein.  However the carboxyl terminal region of the sucrose synthases belongs to the glycosyl transferase family Pfam:PF00534.. 
+PF02657 UPF0050;<br>Fe-S metabolism associated domain. This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export  ).. 
+PF05076 Suppressor of fused protein (SUFU)<br>Pfam-B_6089 (release 7.7). SUFU, encoding the human orthologue of Drosophila suppressor of fused,  appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus  . SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway  . Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems  . . 
+PF04198 Putative sugar-binding domain<br>Pfam-B_1085 (release 7.3). This probable domain is found in bacterial transcriptional regulators such as DeoR and SorC. These proteins have an amino-terminal helix-turn-helix Pfam:PF00325 that binds to DNA. This domain is probably the ligand regulator binding region.  SorC is regulated by sorbose and other members of this family are likely to be regulated by other sugar substrates.. 
+PF00083 sugar_tr; <br>Sugar (and other) transporter. Prosite hmmls-iteration. 
+PF01253 Translation initiation factor SUI1<br>
+PF03846 Cell division inhibitor SulA<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00916 Sulfate transporter family<br>Pfam-B_223 (release 3.0). Mutations in Swiss:P50443 lead to several human diseases.. 
+PF03856 Beta-glucosidase (SUN family)<br>Members of this family include Nca3, Sun4 and Sim1. This is a family of yeast proteins, involved in a diverse set of functions (DNA replication, aging,  mitochondrial biogenesis and cell septation) . BGLA from Candida wickerhamii has been characterised as a Beta-glucosidase EC:3.2.1.21.. 
+PF03439 Supt5;<br>Early transcription elongation factor of RNA pol II, NGN section. Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4  .  Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit  .. 
+PF01975 Survival protein SurE<br>E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase  .  It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family Swiss:P38254.  Swiss:P30887 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.. 
+PF02104 SURF1 family<br>
+PF02077 SURF4 family<br>
+PF01617 Surface antigen<br>Pfam-B_1042 (release 4.1). This family includes a number of bacterial surface antigens expressed on the surface of pathogens.. 
+PF00084 sushi; <br>Sushi domain (SCR repeat). Swissprot_feature_table. 
+PF04099 Sybindin-like family <br>Pfam-B_3240 (release 7.3);. Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses  .. 
+PF02383 SacI homology domain<br>Pfam-B_1090 (release 5.2). This Pfam family represents a protein domain which shows homology to the yeast protein SacI Swiss:P32368. The SacI homology domain is most notably found at the amino terminal of the inositol  5'-phosphatase synaptojanin.. 
+PF02078 Synapsin; Synapsin_N; <br>Synapsin, N-terminal domain. 
+PF02750 Synapsin, ATP binding domain<br>Ca dependent ATP binding in this ATP grasp fold.  Function unknown.. 
+PF00957 synaptobrevin; <br>Pfam-B_303 (release 3.0). 
+PF01284 Synaptophysin; <br>Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins  . It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.. 
+PF01034 Syndecan domain<br>Pfam-B_1182 (release 3.0). Syndecans are transmembrane heparin  sulfate  proteoglycans  which  are   implicated  in  the binding of extracellular matrix components  and growth factors.. 
+PF01387 Synuclein<br>There are three types of synucleins in humans, these are called alpha, beta and gamma.  Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients. . 
+PF00837 Iodothyronine deiodinase<br>Pfam-B_1631 (release 2.1). Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).. 
+PF03903 T4_tail_gp36; <br>
+PF03906 Tail_fibre_T7; T7_tail_fibre; <br>Phage T7 tail fibre protein. The bacteriophage T7 tail complex consists of a conical  tail-tube surrounded by six kinked tail-fibres,  which are oligomers of the viral protein gp17.. 
+PF02217 Origin of replication binding protein<br>Pfam-B_827 (release 5.2). This domain of large T antigen binds to the SV40 origin of DNA replication  . . 
+PF05010 Transforming acidic coiled-coil-containing protein (TACC)<br>Pfam-B_4807 (release 7.6). This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1)  .  The functional homologue (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles  .. 
+PF02202 Tachykinin family<br>Alignment kindly provided by SMART. 
+PF04972 TAD;<br>This domain is found in a family of osmotic shock protection proteins (e.g. Swiss:P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes ( ).. 
+PF02969 TATA box binding protein associated factor (TAF)<br>TAF proteins adopt a histone-like fold.. 
+PF04658 TAFII55 protein conserved region<br>Pfam-B_4395 (release 7.5). The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex.   TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown.  The conserved region is situated towards the N-terminus of the protein  .  . 
+PF05069 tail_comp_S; <br>Phage virion morphogenesis family . TIGRFAMs (release 2.0);. Protein S of phage P2 is thought to be involved in tail completion and stable head joining.. 
+PF02203 Tar ligand binding domain homologue<br>Alignment kindly provided by SMART. 
+PF00539 Transactivating regulatory protein (Tat)<br>The retroviral Tat protein binds to the Tar RNA  .  This activates  transcriptional initiation and elongation from the LTR promoter. Binding is mediated by an arginine rich region.. 
+PF01026 UPF0006;<br>Pfam-B_1370 (release 3.0). This family of proteins are related to a large superfamily of metalloenzymes  .  TatD,  a member of this family has been shown experimentally to be a DNase enzyme.. 
+PF03430 Trans-activating transcriptional regulator <br>Pfam-B_4420 (release 6.6). This family of trans-activating transcriptional regulator (TATR), also known as intermediate early protein 1, are common to the  Nucleopolyhedroviruses.   . 
+PF02668 Taurine catabolism dioxygenase TauD, TfdA family<br>This family consists of taurine catabolism dioxygenases of the TauD, TfdA family.  TauD from E. coli Swiss:P37610 is a alpha-ketoglutarate-dependent taurine dioxygenase  .  This enzyme catalyses the oxygenolytic release of sulfite from taurine  .  TfdA from Burkholderia sp. Swiss:Q45423 is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase  .\.       TfdA from Alcaligenes eutrophus JMP134 Swiss:P10088 is a 2,4-dichlorophenoxyacetate monooxygenase  . Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1  .. 
+PF01361 Tautomerase enzyme<br>This family includes the enzyme 4-oxalocrotonate tautomerase Swiss:Q01468 that catalyses the ketonisation of 2-hydroxymuconate to 2-oxo-3-hexenedioate.. 
+PF02959 HTLV_tat;<br>Pfam-B_1456 (release 6.4). Human T-cell leukaemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukaemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-kappaB  .. 
+PF00683 TGF-bp; <br>Pfam-B_82 (release 2.1). This domain is also known as the 8 cysteine domain. This family includes the hybrid domains  . This cysteine rich repeat is found in TGF binding protein and fibrillin.. 
+PF00566 TBC;<br>Rab-GTPase-TBC domain. Alignment kindly provided by SMART. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.. 
+PF02970 Tubulin binding cofactor A<br>
+PF03558 TBSV core protein P21/P22<br>Pfam-B_3028 (release 7.0). This protein is required for cell-to-cell movement in plants. Furthermore, the membrane-associated protein is dispensable for both replication and transcription  .. 
+PF01840 TCL1/MTCP1 family<br>  & Pfam-B_7391 (Release 8.0). Two related oncogenes, TCL-1 Swiss:P56279 and MTCP-1 Swiss:P56278, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28  . This family contains two repeated motifs that form a single globular domain  .. 
+PF03634 TCP family transcription factor<br>Pfam-B_1979 (release 7.0). This is a family of TCP plant transcription factors.  TCP proteins were named after the first characterised members (TB1, CYC and PCFs) and they are involved in multiple developmental control pathways    .  This region contains a DNA binding basic-Helix-Loop-Helix (bHLP) structure   .. 
+PF03645 Tctex-1 family<br>Pfam-B_2986 (release 7.0). Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction. . 
+PF00838 Translationally controlled tumour protein<br>Pfam-B_1548 (release 2.1). 
+PF03347 Vibrio thermostable direct hemolysin<br>Pfam-B_3633 (release 6.5). 
+PF01285 TEA/ATTS domain family<br>
+PF03848 Tellurite resistance protein TehB<br>TIGRFAMs, Griffiths-Jones SR. 
+PF02765 Telo_bind;<br>Telomeric single stranded DNA binding POT1/CDC13. This domain binds single stranded telomeric DNA and adopts an OB fold  .  It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping [2-4].  POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [5,6].. 
+PF03070 TENA/THI-4/PQQC family<br>Pfam-B_2039 (release 6.4) & Pfam-B_7791 (release 7.7). Members of this family are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase  .  The THI-4 protein, which is involved in thiamine biosynthesis, is also a member of this family. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4  . This family includes bacterial coenzyme PQQ synthesis protein C or PQQC proteins.  Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria  . PQQC has been found to be required in the synthesis of PQQ but its function is unclear.  The exact molecular function of members of this family is uncertain.. 
+PF04876 Tenuivirus major non-capsid protein<br>Pfam-B_6119 (release 7.6). This protein of unknown function accumulates in large amounts in tenuivirus infected cells.  It is found in all forms of the inclusion bodies that are formed after infection  .. 
+PF03300 Tenuivirus non-structural protein NS4<br>Pfam-B_4315 (release 6.5). 
+PF05099 Tellurite resistance protein TerB<br>This family contains the TerB tellurite resistance proteins from a a number of bacteria.. 
+PF03741 Integral membrane protein TerC family<br>This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance  . Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.. 
+PF02342 TerD domain<br>The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins    It is found in a stress response operon with TerB and TerC.  TerD has a maximum of two calcium binding sites {2] depending on the conservation of aspartates {2]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie  at the center of membrane-linked metal recognition complexes  with regulatory ramifications encompassing phosphorylation- dependent signal transduction, RNA-dependent regulation,  biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways  . . 
+PF03592 Terminase_small; <br>Terminase small subunit . Pfam-B_3755 (release 7.0). Packaging of double-stranded viral DNA concatemers requires interaction of the prohead with virus DNA.  This process is mediated by a phage-encoded DNA recognition and terminase protein. The terminase enzymes described so far, which are hetero-oligomers composed of a small and a large subunit, do not have a significant level of sequence homology.  The small terminase subunit is thought to form a nucleoprotein structure that helps to position the terminase large subunit at the packaging initiation site  .. 
+PF03936 Terpene synthase family, metal binding domain<br>Pfam-B_728 (release 3.0). It has been suggested that this gene family be designated tps (for terpene synthase)  .  It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.. 
+PF02909 tetR_C; <br>Tetracyclin repressor, C-terminal all-alpha domain. 
+PF03299 Transcription factor AP-2<br>Pfam-B_1736 (release 6.5). 
+PF02559 CarD; TF_CarD; CarD_TRCF; CarD-CdnL_RID;<br>CarD-like/TRCF domain. CarD is a Myxococcus xanthus protein required for the activation of light- and starvation-inducible genes  . This family includes the presumed N-terminal domain, CdnL.\.      CarD interacts with the zinc-binding protein CarG to form a complex that regulates multiple processes in Myxococcus xanthus  .  This family also includes a domain to the N-terminal side of the DEAD helicase of TRCF (transcription-repair-coupling factor) proteins. TRCF displaces RNA polymerase stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription  . This domain is involved in binding to the stalled RNA polymerase  . The family includes members otherwise referred to as CdnL, for CarD N-terminal like, whichdiffer functionally from CarD. The TRCF domain mentioned above is the RNA polymerase-interacting domain or RID  .. 
+PF03529 Otx1 transcription factor<br>
+PF03849 Transcription factor Tfb2<br>TIGRFAMs, Griffiths-Jones SR. 
+PF03153 Transcription factor IIA, alpha/beta subunit<br>Pfam-B_3542 (release 6.5). Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in Pfam:PF02268 and Pfam:PF02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step  . After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription.. 
+PF02268 TFIIA_gamma; <br>Transcription initiation factor IIA, gamma subunit, helical domain. Pfam-B_4941 (release 5.2). Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The N-terminal domain of the gamma subunit is a 4 helix bundle.. 
+PF02751 Transcription initiation factor IIA, gamma subunit<br>Pfam-B_4941 (release 5.2). Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II.  Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel.. 
+PF02291 TFIID-31; <br>Transcription initiation factor IID, 31kD subunit. Pfam-B_6729 (release 5.2). This family represents the N-terminus of the 31kD subunit (42kD in  drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation.. 
+PF03540 TFIID_30kD; <br>Transcription initiation factor TFIID 23-30kDa subunit. 
+PF02002 TFIIE;<br>The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits TFIIE-alpha Swiss:P29083 and TFIIE-beta Swiss:P29084 and joins the pre-initiation complex after RNA polymerase II and TFIIF  . This family consists of the conserved amino terminal region of eukaryotic TFIIE-alpha   and proteins from archaebacteria that are presumed to be TFIIE-alpha subunits also Swiss:O29501  .. 
+PF02186 TFIIE beta subunit core domain<br>General transcription factor TFIIE consists of two subunits, TFIIE alpha Pfam:PF02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The structure of the DNA binding core region has been solved   and has a winged helix fold.. 
+PF02270 Transcription initiation factor IIF, beta subunit<br>Pfam-B_4519 (release 5.2). Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit  of TFIIF is required for recruitment of RNA polymerase II onto  the promoter.. 
+PF01096 TFIIS; <br>Transcription factor S-II (TFIIS). 
+PF04994 TfoX C-terminal domain<br>TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes  . This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with Pfam:PF00383 in Swiss:Q9JZR1.  It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.. 
+PF04993 TfoX N-terminal domain<br>TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes  . This family corresponds to the N-terminal presumed domain of TfoX. The domain is found as an isolated domain in some proteins suggesting this is an autonomous domain.. 
+PF00019 TGF-beta; <br>Transforming growth factor beta like domain. 
+PF00688 TGF-beta propeptide<br>Pfam-B_110 (release 2.1). This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.. 
+PF01702 Queuine tRNA-ribosyltransferase<br>Pfam-B_1643 (release 4.1). This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine,  aspartic acid, histidine and tyrosine with queuine.  It catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol  moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified  base queuine in the wobble position [1,2]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H,  and important tRNA and 7-aminomethyl-7deazaguanine binding residues  .. 
+PF04858 TH1 protein<br>Pfam-B_6070 (release 7.6). TH1 is a highly conserved but uncharacterised metazoan protein.  No homologue has been identified in Caenorhabditis elegans  .  TH1 binds specifically to A-Raf kinase  .. 
+PF00314 thaumatin; <br>
+PF01946 Thi4 family<br>This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.. 
+PF01964 ThiC family<br>ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis  . The precise catalytic function of ThiC is still not known. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis.. 
+PF02568 Thiamine biosynthesis protein (ThiI)<br>ThiI is required for thiazole synthesis, required for thiamine biosynthesis  .. 
+PF00975 Thioesterase domain<br>Pfam-B_180 (release 3.0). Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics.  Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates.  There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.. 
+PF01289 Thiol-activated cytolysin<br>
+PF00108 thiolase; <br>Thiolase, N-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl  synthase (Pfam:PF00109), and also chalcone synthase.. 
+PF02803 thiolase_C; <br>Thiolase, C-terminal domain. Thiolase is reported to be structurally related to beta-ketoacyl  synthase (Pfam:PF00109), and also chalcone synthase.. 
+PF00085 thiored; <br>Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.. 
+PF00585 Thr_dehydratase_C;<br>C-terminal regulatory domain of Threonine dehydratase. Threonine dehydratases Pfam:PF00291 all contain a carboxy terminal region.  This region may have a regulatory role. Some members contain two copies of this region. This family is homologous to the Pfam:PF01842 domain.. 
+PF04163 Tht1-like nuclear fusion protein <br>Pfam-B_64620 (release 7.3);. 
+PF02926 THUMP domain<br>The THUMP domain is named after after thiouridine synthases, methylases and PSUSs  . The THUMP domain consists of about 110 amino acid residues.  The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains  . It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets  .. 
+PF02511 Thymidylate synthase complementing protein<br>Pfam-B_1648 (release 5.4). Thymidylate synthase complementing protein (Thy1) complements the thymidine growth requirement of the organisms in which it is found, but shows no homology to thymidylate synthase.. 
+PF00303 thymidylat_synt; <br>Thymidylate synthase. Swiss:P28176 is not included as a member of this family, Although annotated as such there is no significant sequence similarity to other members.. 
+PF02223 Thymidylate kinase<br>Pfam-B_484 (release 5.2). 
+PF01290 Thymosin beta-4 family<br>
+PF00086 thyroglobulin_1; <br>Thyroglobulin type-1 repeat. Swissprot_feature_table. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation  . The domain usually contains six conserved cysteines.  These form three disulphide bridges.  Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.. 
+PF04278 Tic22-like family<br>TIGRFAMs (release 2.0);. The preprotein translocation at the inner envelope membrane of  chloroplasts so far involves five proteins: Tic110, Tic55,  Tic40, Tic22 (this family) and Tic20. The molecular function of  these proteins has not yet been established  . . 
+PF01826 Trypsin Inhibitor like cysteine rich domain<br>This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.. 
+PF00121 Triosephosphate isomerase<br>
+PF02466 Tim17/Tim22/Tim23/Pmp24 family<br>Pfam-B_2241 (release 5.4) & Pfam-B_7792 (Release 8.0). The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane.  This family includes Tim17, Tim22 and Tim23. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 in  .. 
+PF04821 Timeless protein<br>Pfam-B_3454 (release 7.6). The timeless gene in Drosophila melanogaster and its homologues in a number of other insects and mammals (including human) are involved in circadian rhythm control  . This family includes a related proteins from a number of fungal species.. 
+PF05029 Timeless protein C terminal region<br>Pfam-B_5695 (release 7.6). The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2)  . mTim has been shown to be essential for  embryonic development, but does not have substantiated circadian  function . Some family members contain a SANT domain in this region.. 
+PF00965 Tissue inhibitor of metalloproteinase<br>Pfam-B_1239 (release 3.0). Members of this family are common in extracellular regions of vertebrate species. 
+PF03549 Tir_receptor; <br>Translocated intimin receptor (Tir) intimin-binding domain. Griffiths-Jones SR, Moxon SJ. Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation  . This family represents the Tir intimin-binding domain (Tir IBD) which is needed to bind intimin and support the predicted topology for Tir, with both N- and C-terminal regions in the mammalian cell cytosol  . . 
+PF04553 Tis11B_C;<br>Tis11B like protein, N terminus. Members of this family always contain a tandem repeat of CCCH zinc fingers Pfam:PF00642.  Tis11B, Tis11D and their homologues are thought to be regulatory proteins involved in the response to growth factors.  The function of the N terminus is unknown.. 
+PF01108 Tissue factor<br>This family is found in metazoa, and is very similar to the fibronectin type III domain.  The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family Pfam:PF00041.. 
+PF00265 Thymidine kinase<br>
+PF00693 TK_herpes; <br>Thymidine kinase from herpesvirus. Pfam-B_186 (release 2.1). 
+PF03219 TLC ATP/ADP transporter<br>Pfam-B_2261 (release 6.5). 
+PF05017 TMP repeat<br>Pfam-B_1012 (release 7.6). This short repeat consists of the motif WXXh where X can be any residue and h is a hydrophobic residue. The repeat is name TMP after its occurrence in the  tape measure protein (TMP). Tape measure protein is a component of phage tail and probably forms a beta-helix. Truncated forms of TMP lead to shortened tail fibres  . This repeat is also found in non-phage proteins where it may play a structural role.. 
+PF02581 Thiamine monophosphate synthase/TENI<br>Thiamine monophosphate synthase (TMP) (EC:2.5.1.3) catalyses the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine  phosphate  . This Pfam family also includes the regulatory protein TENI (Swiss:P25053).. 
+PF00721 Virus coat protein (TMV like)<br>Pfam-B_746 (release 2.1). This family contains coat proteins from tobamoviruses, hordeiviruses, Tobraviruses, Furoviruses and Potyviruses.. 
+PF00229 TNF(Tumour Necrosis Factor) family <br>
+PF00020 TNFR/NGFR cysteine-rich region<br>Swissprot_feature_table. 
+PF01107 Tobamo_MP; <br>Viral movement protein (MP). Pfam-B_815 (release 3.0) & Pfam-B_1906 (release 4.1). This family includes a variety of movement proteins (MP)s. The MP is necessary for the initial cell-to-cell movement during the early stages of a viral infection.  This movement is active, and it is known that the MP interacts with the plasmodesmata and possesses the ability to bind to RNA to achieve its role  . This family also includes consists of virus movement proteins from the caulimovirus family. It has been suggested in cauliflower mosaic virus that these proteins mediated viral movement by modifying plasmodesmata and forming tubules in the channel that can accommodate the virus particles   and references therein. The family contains a conserved DXR motif that is probably functionally important.. 
+PF04052 TolB amino-terminal domain<br>TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.. 
+PF03349 Outer membrane protein transport protein (OMPP1/FadL/TodX)<br>Pfam-B_3708 (release 6.5). This family includes TodX from Pseudomonas putida F1 Swiss:Q51971 and TbuX from Ralstonia pickettii PKO1 Swiss:Q9RBW8. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD Swiss:O33458. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.. 
+PF04281 Mitochondrial import receptor subunit Tom22 <br>TIGRFAMs (release 2.0);. The mitochondrial protein translocase family, which is responsible for movement of nuclear encoded pre-proteins into mitochondria, is very complex with at least 19 components. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins.  This family represents the Tom22 proteins  .  The N terminal region of Tom22 has been shown to have chaperone-like activity, and the C terminal region faces the intermembrane face  .. 
+PF03220 Tombusvirus P19 core protein<br>Pfam-B_2714 (release 6.5). 
+PF03544 TonB;<br>Gram-negative bacterial TonB protein C-terminal. The TonB_C domain is the well-characterised C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane  . TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance  .. 
+PF00593 TonB_boxC; <br>TonB dependent receptor. This model now only covers the conserved part of the barrel structure.. 
+PF01131 DNA topoisomerase<br>Pfam-B_505 (release 3.0). This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax  negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.. 
+PF02919 Topoisomer_I_N; <br>Eukaryotic DNA topoisomerase I, DNA binding fragment. Pfam-B_1377 (release 3.0). Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination  . This family may be more than one structural domain.. 
+PF01028 Topoisomerase_I; <br>Eukaryotic DNA topoisomerase I, catalytic core. Pfam-B_1377 (release 3.0). Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination  .. 
+PF01751 Primase;<br>Pfam-B_500 (release 4.2). This is a conserved region from DNA primase. This corresponds to  the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins  . Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely  abolish DnaG type primase activity  . DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division  . This family also includes the atypical archaeal A subunit from type II DNA topoisomerases  . Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks.. 
+PF01533 Tospovirus nucleocapsid protein<br>Pfam-B_950 (release 4.0). The tospovirus genome consists of three linear ssRNA segments, denoted L, M and S complexed with the nucleocapsid protein. The S RNA encodes the nucleocapsid protein and another non-structural protein  .. 
+PF00087 toxin; toxin_1; <br>A family of venomous neurotoxins and cytotoxins. Structure is small, disulfide-rich, nearly all beta sheet.. 
+PF00451 toxin_2; <br>Scorpion short toxin, BmKK2. Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity  .. 
+PF00537 toxin_3; <br>Scorpion toxin-like domain . Pfam-B_8170 (release 8.0). This family contains both neurotoxins and plant defensins.  The mustard trypsin inhibitor, MTI-2, is plant defensin. It is a potent inhibitor of trypsin with no activity towards chymotrypsin. MTI-2 is toxic for Lepidopteran insects, but has low activity against aphids  .  Brazzein is plant defensin-like protein. It is pH-stable, heat-stable and intensely sweet protein  . The scorpion toxin (a neurotoxin) binds to sodium channels and inhibits the activation mechanisms of the channels, thereby blocking neuronal transmission. Scorpion toxins bind to sodium channels and inhibit the activation mechanisms of the channels, thereby blocking neuronal transmission. 
+PF00706 toxin_4; <br>Pfam-B_589 (release 2.1). 
+PF02079 Nuclear transition protein 1<br>
+PF01254 Nuclear transition protein 2<br>
+PF04406 Type IIB DNA topoisomerase<br>Type II DNA topoisomerases are ubiquitous enzymes that catalyse the ATP-dependent transport of one DNA duplex through a second DNA segment via a transient double-strand break.  Type II DNA topoisomerases are now subdivided into two sub-families, type IIA and IIB DNA topoisomerases.  TP6A_N is present in type IIB topoisomerase and is thought to be involved in DNA binding owing to its sequence similarity to E. coli catabolite activator protein (CAP)  . . 
+PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases<br>MRC-LMB Genome group. This family uses S-AdoMet in the methylation of diverse substrates.  This family includes a related group of bacterial proteins of unknown function, including Swiss:P45528.\.   This family includes the methylase Dipthine synthase.. 
+PF04201 Tumour protein D52 family<br>Pfam-B_2632 (release 7.3). The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family  . These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other  .. 
+PF00205 TPP_enzymes; <br>Thiamine pyrophosphate enzyme, central domain. The central domain of TPP enzymes contains a 2-fold Rossman fold.. 
+PF02775 TPP_enzymes_C; <br>Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. 
+PF02776 TPP_enzymes_N; <br>Thiamine pyrophosphate enzyme, N-terminal TPP binding domain. 
+PF01963 TraB family<br>pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once the plasmid pAD1 is acquired, production of the pheromone ceases--a trait related in part to a determinant designated traB. However a related protein is found in C. elegans Swiss:Q94217, suggesting that members of the TraB family have some more general function. This family also includes the bacterial GumN protein. The family has a conserved GXXH motif close to the N-terminus, a conserved glutamate and a conserved arginine that may be catalytic. The family also includes a second conserved GXXH motif near the C-terminus.. 
+PF02534 TRAG; TraG;<br>Type IV secretory system Conjugative DNA transfer. Pfam-B_1146 (release 5.4). These proteins contain a P-loop and walker-B site for nucleotide binding. TraG is essential for DNA transfer in bacterial conjugation.  These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems  .  The C-terminus of this domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore  . The family contains a number of different DNA transfer proteins  .. 
+PF00923 Transaldolase<br>Pfam-B_787 (release 3.0). 
+PF00382 transcript_fac2; <br>Transcription factor TFIIB repeat. 
+PF00405 transferrin; <br>
+PF00868 Transglutaminas; Transglutamin_N; <br>Transglutaminase family. Pfam-B_783 (release 3.0). 
+PF00912 Transglycosyl; <br>Pfam-B_558 (release 3.0). The penicillin-binding proteins are bifunctional proteins consisting of  transglycosylase and transpeptidase in the N- and C-terminus  respectively  . The transglycosylase domain catalyses the  polymerisation of murein glycan chains ( ).. 
+PF00456 transketolase; <br>Transketolase, thiamine diphosphate binding domain. This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4.  Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.. 
+PF01818 Bacteriophage translational regulator<br>The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs  .. 
+PF01997 DUF130;<br>Members of this family include Translin Swiss:Q15631 that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen  .. 
+PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin<br>
+PF04236 Tc5 transposase C-terminal domain<br>Pfam-B_2955 (release 6.5). 
+PF00872 Transpo_mutator; <br>Transposase, Mutator family. Pfam-B_376 (release 3.0). 
+PF00273 transport_prot; <br>Serum albumin family. 
+PF01359 Transposase (partial DDE domain)<br>Pfam-B_394 (release 3.0). This family includes the mariner transposase  .. 
+PF01610 Transposase_12;<br>Pfam-B_1015 (release 4.1). Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204 (Swiss:Q50911)  , IS1001 (Swiss:Q06126)  , IS1096 (Swiss:Q50440)   and IS1165 Swiss:Q48788  .. 
+PF01710 Transposase_14;<br>Pfam-B_1769 (release 4.1). Transposase proteins are necessary for efficient DNA transposition. This family includes insertion sequences from Synechocystis PCC 6803 three of which are characterised as homologous to bacterial IS5- and IS4- and to several members of the IS630-Tc1-mariner superfamily  .. 
+PF01797 Transposase_17;<br>Transposase IS200 like. Pfam-B_1347 (release 4.2). Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.. 
+PF01385 Transposase_2;<br>Probable transposase. Pfam-B_1210 (release 3.0) & Pfam-B_4602 (Release 7.5). This family includes IS891  , IS1136   and IS1341  . DUF1225, Pfam:PF06774, has now been merged into this family.. 
+PF02992 Transposase family tnp2<br>Pfam-B_1531 (release 6.4). 
+PF02994 L1 transposable element<br>Pfam-B_2299 (release 6.4). 
+PF03017 TNP1/EN/SPM transposase<br>Pfam-B_1491 (release 6.4). 
+PF03004 Plant transposase (Ptta/En/Spm family)<br>Pfam-B_1902 (release 6.4). Transposase proteins are necessary for efficient DNA transposition. This family includes various plant transposases from the Ptta and En/Spm families.. 
+PF03050 Transposase_25;<br>Transposase IS66 family . Pfam-B_2526 (release 6.4). Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens  .. 
+PF03400 Transposase_27;<br>Pfam-B_2448 (release 6.6). Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.. 
+PF04195 Putative gypsy type transposon<br>Pfam-B_1755 (release 7.3). This family of plant genes are thought to be related to gypsy type transposons.. 
+PF04693 Transposase_29;<br>Archaeal putative transposase ISC1217. Pfam-B_5730 (release 7.5). 
+PF04740 LXG domain of WXG superfamily<br>Zhang D, Mifsud W, Aravind L. Pfam-B_3568 (release 7.5). This domain is present is the N-terminal region of a group of polymorphic toxin proteins in bacteria. It is predicted  to use Type VII secretion pathway to mediate export of bacterial toxins  .. 
+PF04754 Putative transposase, YhgA-like<br>Pfam-B_3820 (release 7.5). This family of putative transposases includes the YhgA sequence from Escherichia coli (Swiss:P31667) and several prokaryotic homologues.. 
+PF04986 Transposase_32;<br>Putative transposase. Pfam-B_5271 (release 7.6). Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases IS1294 and IS801. This is a rolling-circle transposase.. 
+PF01498 Transposase_5;<br>Pfam-B_462 (release 4.0). Transposase proteins are necessary for efficient DNA transposition.  This family includes the amino-terminal region of Tc1, Tc1A, Tc1B and Tc2B transposases of C.elegans.  The region encompasses the specific DNA binding and second DNA recognition domains as well as an amino-terminal region of the catalytic domain of Tc3 as described in  . Tc3 is a member of the Tc1/mariner family of transposable elements.. 
+PF01527 Transposase_8;<br>Pfam-B_527 (release 4.0). Transposase proteins are necessary for efficient DNA transposition.  This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.. 
+PF03221 Transposase_Tc5;<br>Tc5 transposase DNA-binding domain. Pfam-B_2955 (release 6.5). 
+PF02281 Transposase_Tn5;<br>Transposase Tn5 dimerisation domain. Pfam-B_5683 (release 5.2). Transposons are mobile DNA sequences capable of replication and insertion into the chromosome. Typically transposons code for  the transposase enzyme, which catalyses insertion, found between terminal inverted repeats. Tn5 has a unique method of self- regulation in which a truncated version of the transposase enzyme acts as an inhibitor  . The catalytic domain of the Tn5 transposon is found in Pfam:PF01609.  This domain mediates dimerisation in the known structure.. 
+PF00576 HIUase/Transthyretin family<br>This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain.  However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU [2,3].  HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage  . HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.. 
+PF03896 TRAP-alpha; <br>Translocon-associated protein (TRAP), alpha subunit. The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane  .. 
+PF04051 TRAPP_Bet3; <br>Transport protein particle (TRAPP) component. Pfam-B_9946 (release 7.3) & Pfam-B_6495 (release 8.0). TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits.  This family contains many TRAPP family proteins.  The Bet3 subunit is one of the better characterised TRAPP proteins and has a dimeric structure   with hydrophobic channels.  The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues.  Bet3 is proposed to localise TRAPP to the Golgi  .. 
+PF04956 TrbC/VIRB2 family<br>Pfam-B_5261 (release 7.6) & Pfam-B_14627 (release 10.0). Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure . This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species  .. 
+PF03743 Bacterial conjugation TrbI-like protein <br>Pfam-B_776 (release 7.0). Although not essential for conjugation, the TrbI protein greatly increase the conjugational efficiency  .. 
+PF04610 TrbL/VirB6 plasmid conjugal transfer protein<br>Pfam-B_5275 (release 7.5) & COG3704. 
+PF03461 TRCF domain<br>
+PF03546 treacle; <br>Treacher Collins syndrome protein Treacle. 
+PF00088 trefoil; <br>Trefoil (P-type) domain. Swissprot_feature_table. 
+PF01204 Trehalase<br>Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with Pfam:PF07492 in fungi.. 
+PF02358 Trehalose-phosphatase<br>Pfam-B_762 (release 5.2). This family consist of trehalose-phosphatases EC:3.1.3.12 these enzyme catalyse the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate.  The aligned region is present in  trehalose-phosphatases and comprises the entire length of the protein it is also found in the C-terminus of trehalose-6-phosphate synthase  EC:2.4.1.15 adjacent to the trehalose-6-phosphate synthase domain - Pfam:PF00982.  It would appear that the two equivalent genes in the  E. coli otsBA operon   otsA the trehalose-6-phosphate synthase and otsB trehalose-phosphatase (this family) have undergone gene fusion in most eukaryotes e.g. Swiss:P31688 and Swiss:P93653. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance  .. 
+PF03973 Triabin<br>Pfam-B_20829 (release 7.1). Triabin is a serine-protease inhibitor.. 
+PF02080 TrkA;TrkA-C; <br>This domain is often found next to the Pfam:PF02254 domain.  The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand  .  The domain is predicted to adopt an all beta structure  .. 
+PF02254 KTN;TrkA-N; <br>Pfam-B_289 (Release 5.3). This domain is found in a wide variety of proteins. These protein include potassium channels Swiss:P31069, phosphoesterases Swiss:Q59027, and various other transporters.  This domain binds to NAD.. 
+PF02386 Cation transport protein<br>Pfam-B_529 (release 5.2). This family consists of various cation transport proteins (Trk) and  V-type sodium ATP synthase subunit J or translocating ATPase J EC:3.6.1.34. These proteins are involved in active sodium up-take utilising ATP in the process.  TrkH a member of the family Swiss:P76769 from E. coli is a  hydrophobic membrane protein and determines the specificity and kinetics  of cation transport by the TrK system in E. coli  .. 
+PF02005 N2,N2-dimethylguanosine tRNA methyltransferase<br>This enzyme EC:2.1.1.32 used S-AdoMet to methylate tRNA. The TRM1 gene of Saccharomyces cerevisiae is necessary for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNAs  . The enzyme is found in both eukaryotes and archaebacteria  . 
+PF00133 tRNA synthetases class I (I, L, M and V)<br>Other tRNA synthetase sub-families are too dissimilar to be included.. 
+PF00749 tRNA synthetases class I (E and Q), catalytic domain<br>Pfam-B_350 (release 2.1). Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).. 
+PF03950 tRNA synthetases class I (E and Q), anti-codon binding domain<br>Pfam-B_350 (release 2.1). Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).. 
+PF00750 tRNA synthetases class I (R)<br>Pfam-B_1276 (release 2.1). Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only arginyl tRNA synthetase.. 
+PF01406 tRNA synthetases class I (C) catalytic domain<br>This family includes only cysteinyl tRNA synthetases.. 
+PF01921 tRNA synthetases class I (K)<br>This family includes only lysyl tRNA synthetases from prokaryotes.. 
+PF00152 tRNA synthetases class II (D, K and N) <br>
+PF02081 Tryptophan RNA-binding attenuator protein<br>
+PF00587 tRNA synthetase class II core domain (G, H, P, S and T)<br>MRC-LMB Genome group. Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.. 
+PF01411 tRNA synthetases class II (A)<br>Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.. 
+PF01974 tRNA intron endonuclease, catalytic C-terminal domain<br>Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.. 
+PF02778 tRNA intron endonuclease, N-terminal domain<br>Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.. 
+PF01746 tRNA (Guanine-1)-methyltransferase<br>Pfam-B_2049 (release 4.1). This is a family of tRNA (Guanine-1)-methyltransferases  EC:2.1.1.31. In E.coli K12 this enzyme catalyses the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA  .. 
+PF03054 tRNA methyl transferase<br>Pfam-B_823 (release 6.4). This family represents  tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside  5-methylaminomethyl-2-thiouridine present in the wobble position  of some tRNAs  .. 
+PF04558 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1    <br>This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli.\.       This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function  .. 
+PF04557 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2    <br>This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli.\.   This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function  .. 
+PF02091 tRNA_synt_A;tRNA_synt_2e;<br>Glycyl-tRNA synthetase alpha subunit. 
+PF02092 tRNA_synt_B; <br>Glycyl-tRNA synthetase beta subunit. 
+PF00261 Tropomyosin<br>
+PF03301 Tryptophan 2,3-dioxygenase<br>Pfam-B_4263 (release 6.5). 
+PF04820 Tryptophan halogenase<br>Pfam-B_2531 (release 7.6). Tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan.  This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent  .. 
+PF01371 Trp repressor protein<br>This protein binds to tryptophan and represses transcription of the Trp operon.. 
+PF00290 trp_syntA; <br>Tryptophan synthase alpha chain. 
+PF03222 Tryptophan/tyrosine permease family<br>Pfam-B_2873 (release 6.5). 
+PF01509 TruB family pseudouridylate synthase (N terminal domain)<br>Pfam-B_792 (release 4.0). Members of this family are involved in modifying bases in RNA molecules.  They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA  .. 
+PF01456 Tryp_mucin; <br>Mucin-like glycoprotein. Prodom_3102 (release 99.1) & Pfam-B_3837 (Release 8.0). This family of trypanosomal proteins resemble vertebrate mucins. The protein consists of three regions. The N and C terminii are conserved between all members of the family, whereas the central region is not well conserved and contains a large number of threonine residues which can be glycosylated  . Indirect evidence suggested that these genes might encode the core protein of parasite mucins, glycoproteins that were proposed to be involved in the interaction with, and invasion of, mammalian host cells. This family contains an N-terminal signal peptide.. 
+PF00913 Trypanosome variant surface glycoprotein (A-type)<br>Pfam-B_1351 (release 3.0) & Pfam-B_2618 (release 8.0). The trypanosome parasite expresses these proteins to evade the immune response. This family includes a variety of surface proteins such as Trypanosoma brucei VSGs such as expression site associated gene (ESAG) 6 and 7  .. 
+PF03249 Type specific antigen<br>Pfam-B_3060 (release 6.5). There are several antigenic variants in Rickettsia tsutsugamushi, and a type-specific antigen (TSA) of 56-kilodaltons located on the rickettsial surface is responsible for the variation [1,2]. TSA proteins are probably integral membrane proteins.. 
+PF01166 TSC-22/dip/bun family<br>
+PF04668 Twisted gastrulation (Tsg) protein conserved region<br>Pfam-B_4556 (release 7.5). Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling [1,2].  . 
+PF04705 Thiostrepton-resistance methylase, N terminus<br>This region is found in some members of the SpoU-type rRNA methylase family (Pfam:PF00588).. 
+PF00090 tsp_1; <br>Thrombospondin type 1 domain. 
+PF02412 tsp_3;<br>Thrombospondin type 3 repeat. SwissProt & Pfam-B_2972 (Release 8.0). The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats  . The repeat lacks defined secondary structure  .. 
+PF03073 TspO/MBR family<br>Pfam-B_1882 (release 6.4). Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light  . It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates  . In  , the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.. 
+PF02956 TT viral orf 1<br>Pfam-B_1612 (release 6.4). TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.. 
+PF02957 TT viral ORF2<br>Pfam-B_1489 (release 6.4) & Pfam-B_4693 (release 7.6). TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.. 
+PF03542 Tuberin<br>Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. The TSC2 gene codes for tuberin and interacts with hamartin Pfam:PF04388 , containing two coiled-coil regions, which have been shown to mediate binding to tuberin. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking  .. 
+PF00091 tubulin; <br>Tubulin/FtsZ family, GTPase domain. This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.. 
+PF00418 tubulin-binding; <br>Tau and MAP protein, tubulin-binding repeat. This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilise microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau (Swiss:P10636) is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif  .. 
+PF01021 TYA transposon protein<br>Pfam-B_90 (release 3.0). Ty are yeast transposons.\.   A 5.7kb transcript codes for p3 a fusion protein of TYA and TYB.  The TYA protein is analogous to the gag protein of retroviruses. TYA a is cleaved to form 46kd protein which can form mature virion like particles  .. 
+PF03251 Tymovirus 45/70Kd protein<br>Pfam-B_3418 (release 6.5). Tymoviruses are single stranded RNA viruses.  This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase  .. 
+PF00983 Tymovirus coat protein<br>Pfam-B_1429 (release 2.1). 
+PF00264 tyrosinase; <br>Common central domain of tyrosinase. This family also contains polyphenol oxidases and some  hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.. 
+PF03064 HSV U79 / HCMV P34<br>Pfam-B_2985 (release 6.4). This family represents herpes virus protein U79 and  cytomegalovirus early phosphoprotein P34 (UL112).. 
+PF02134 UBACT_repeat;<br>Repeat in ubiquitin-activating (UBA) protein. 
+PF01977 DUF117; UPF0096; <br>3-octaprenyl-4-hydroxybenzoate carboxy-lyase. This family has been characterised as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes  . This enzyme catalyses the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+  .. 
+PF01209 ubiE/COQ5 methyltransferase family<br>
+PF03981 Ubiquinol-cytochrome C chaperone <br>Pfam-B_5272 (release 7.2). 
+PF02271 Ubiquinol-cytochrome C reductase complex 14kD subunit<br>Pfam-B_4192 (release 5.2). The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex  . This Pfam family represents the 14kD (or VI) subunit of the complex which is not directly involved in electron transfer, but has a role in assembly of the complex  .. 
+PF02320 Ubiquinol-cytochrome C reductase hinge protein<br>Pfam-B_11849 (release 5.2). The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex  . This Pfam family represents the 'hinge' protein of the complex which is thought to mediate formation of the cytochrome c1 and cytochrome c complex.. 
+PF02921 Ubiquinol cytochrome reductase transmembrane region<br>Each subunit of the cytochrome bc1 complex provides a single helix (this family) to make up the transmembrane region of the complex.. 
+PF02939 UcrQ family<br>The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex  . This family represents the  9.5 kDa subunit of the complex. . 
+PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain<br>Pfam-B_1105 (release 3.0). The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate  .. 
+PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain<br>Pfam-B_1105 (release 3.0). The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate  .. 
+PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain<br>Pfam-B_1105 (release 3.0). The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate  .. 
+PF01704 UTP--glucose-1-phosphate uridylyltransferase<br>Pfam-B_1634 (release 4.1). This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and  Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyses the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi  . UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type  . In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle  . Also within the family is UDP-N-acetylglucosamine Swiss:Q16222 or AGX1   and two hypothetical proteins from Borrelia burgdorferi the lyme disease  spirochaete Swiss:O51893 and Swiss:O51036.. 
+PF00201 UDP-glucoronosyl and UDP-glucosyl transferase<br>
+PF03152 Ubiquitin fusion degradation protein UFD1<br>Pfam-B_3272 (release 6.5). Post-translational ubiquitin-protein conjugates are recognised for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified  . This family includes UFD1, a 40kD protein that is essential for vegetative cell viability  . The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterised by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated  with these conditions are thought to be due to defective neural crest cell differentiation  .. 
+PF02512 UK_protein; <br>Virulence determinant. Pfam-B_2106 (release 5.4). The UK protein is an African swine fever virus (ASFV) protein that  is highly conserved amongst strains, and is an important viral virulence determinant for domestic pigs  .. 
+PF03044 UL16_UL94; <br>Herpesvirus UL16/UL94 family. Pfam-B_4392 (release 6.4). This family groups together HSV-1 UL16 Swiss:P10200, HSV-6 ORF11R Swiss:P24442, EHV-1 46 Swiss:P28970, HCMV UL94 Swiss:P16800, EBV BGLF2 Swiss:P03221 and VZV 44 Swiss:P09293. UL16 protein may play a role in capsid maturation including DNA  packaging/cleavage  . In immunofluorescence studies  , UL16 was localised to the nucleus of infected cells in areas containing high concentrations of HSV capsid proteins. These nuclear compartments have been described previously as viral assemblons   and are distinct from compartments containing replicating DNA. Localisation within assemblons argues for a role of UL16 encoded protein in capsid assembly or maturation  .. 
+PF03252 UL21; <br>Pfam-B_3264 (release 6.5). The UL21 protein appears to be a dispensable component in herpesviruses  .. 
+PF01499 UL25; <br>Herpesvirus UL25 family. Pfam-B_700 (release 4.0). The herpesvirus UL25 gene product is a virion component involved in virus penetration   and capsid assembly.  The product of the UL25 gene is required for packaging but not cleavage of replicated viral DNA  . This family includes a number of herpesvirus proteins: EHV-1 36, EBV BVRF1 Swiss:P03233, HCMV UL77 Swiss:P16726, ILTV ORF2 Swiss:P23987, and VZV gene 34 Swiss:P09287.. 
+PF04496 UL35; <br>Herpesvirus UL35 family . Pfam-B_3981 (release 7.5). UL35 represents a true late gene which encodes a 12-kDa  capsid protein  .. 
+PF03970 UL37;<br>Herpesvirus UL37 tegument protein. UL37 interacts with UL36, which is thought to be an important early step in tegumentation during virion morphogenesis in the cytoplasm  .. 
+PF02282 UL42; <br>DNA polymerase processivity factor (UL42). Pfam-B_5119 (release 5.2). The DNA polymerase processivity factor (UL42) of herpes simplex virus forms a heterodimer with UL30 to create the viral DNA polymerase complex. UL42 functions to increase the processivity of polymerisation and makes little contribution to the catalytic activity of the  polymerase.. 
+PF03117 UL49; <br>Pfam-B_2110 (release 6.5). Members of this family, found in several herpesviruses, include EBV BFRF2 Swiss:P14347 and other UL49 proteins (e.g. HCMVA UL49 Swiss:P16786, HSV6 U33 Swiss:P52441). There are eight conserved cysteine residues in this alignment, all lying towards the C-terminus. Their function is unknown.. 
+PF03121 UL52_UL70; <br>Herpesviridae UL52/UL70 DNA primase. Pfam-B_203 (release 6.5). Herpes simplex virus type 1 DNA replication in host cells is known to be mediated by seven viral-encoded proteins, three of which form a heterotrimeric DNA helicase-primase complex. This complex consists of UL5, UL8, and UL52 subunits.  Heterodimers consisting of UL5 and UL52 have been shown to retain both helicase and primase activities. Nevertheless, UL8 is still essential for replication: though it lacks any DNA binding or catalytic activities, it is involved in the transport of UL5-UL52 and it also interacts with other replication proteins. The molecular mechanisms of the UL5-UL52 catalytic activities are not known. While UL5 is associated with DNA helicase activity and UL52 with DNA primase activity, the helicase activity requires the interaction of UL5 and UL52 [see 2,3]. It is not known if the primase activity can be maintained by UL52 alone. The region encompassed by residues 610-636 of HSV1 UL52 Swiss:P10236 is thought to contain a divalent metal cation binding motif. Indeed, this region contains several aspartate and  glutamate residues that might be involved in divalent cation binding. The biological significance of UL52-UL8 interaction is not known. Yeast two-hybrid analysis together with immunoprecipitation experiments  have shown that the HSV1 UL52 region between residues 366-914 is essential for this interaction, while the first 349 N-terminal residues are dispensable  .  This family also includes protein UL70 from cytomegalovirus (CMV, a subgroup of the Herpesviridae) strains (e.g. Swiss:P17149), which, by analogy with UL52, is thought to have DNA primase activity. Indeed, CMV  strains also possess a DNA helicase-primase complex, the other subunits  being protein UL105 (with known similarity to HSV1 UL5) and protein UL102.. 
+PF03049 UL79; <br>Pfam-B_2433 (release 6.4). Members of this family are functionally uncharacterised proteins from herpesviruses. This family groups together HSV-6 U52 Swiss:P52469, HVS-1 18 Swiss:Q01003 and HCMV UL79 Swiss:P16752.. 
+PF03043 UL87; <br>Herpesvirus UL87 family. Pfam-B_1736 (release 6.4). Members of this family are functionally uncharacterised. This family groups together EBV BcRF1 Swiss:P25215, HSV-6 U58 Swiss:P24437, HVS-1 24 Swiss:Q01007 and HCMV UL87 Swiss:P16730. The proteins range from 575 to 950 amino acids in length.. 
+PF03048 2111; UL92; <br>Pfam-B_2111 (release 6.4). 
+PF03038 UL95; <br>Pfam-B_2060 (release 6.4). Members of this family, found in several herpesviruses, include EBV BGLF3 Swiss:P03220 and other UL95 proteins (e.g. HCMV UL95 Swiss:P16801,  HVS-1 34 Swiss:Q01023, HSV6 U67 Swiss:P24444). Their function is unknown.. 
+PF04817 Umbravirus long distance movement (LDM) family <br>Pfam-B_5103 (release 7.6). The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants  .. 
+PF00021 u-PAR/Ly-6 domain<br>This extracellular disulphide bond rich domain is related to Pfam:PF00087.. 
+PF00919 Uncharacterized protein family UPF0004<br>Pfam-B_1257 (release 3.0). This family is the N terminal half of the Prosite family. The C-terminal half has been shown to be related to MiaB proteins [1,2]. This domain is a nearly always found in conjunction with Pfam:PF04055 and Pfam:PF01938 although its function is uncertain.. 
+PF03649 Uncharacterised protein family (UPF0014)<br>
+PF01169 Uncharacterized protein family UPF0016<br>This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.. 
+PF01170 Putative RNA methylase family UPF0020<br>This domain is probably a methylase.  It is associated with the THUMP domain that also occurs with RNA modification domains  .. 
+PF01171 UPF0021;ATP_bind3; <br>This family of proteins belongs to the PP-loop superfamily  .. 
+PF01172 UPF0023; <br>Shwachman-Bodian-Diamond syndrome (SBDS) protein . This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.  It is characterised by bone marrow failure and leukemia predisposition.  Members of this family play a role in RNA metabolism    .  In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes  .  This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition  .. 
+PF01142 tRNA pseudouridine synthase D (TruD)<br>TruD is responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs  .  The structure of TruD reveals an overall V-shaped molecule which contains an RNA-binding cleft  .. 
+PF01139 UPF0027;<br>tRNA-splicing ligase RtcB. This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyse the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage [1-3].. 
+PF01205 Uncharacterized protein family UPF0029<br>
+PF01256 UPF0031; carb_kinase;<br>This family is related to Pfam:PF02110 and Pfam:PF00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).. 
+PF00902 UPF0032; <br>Sec-independent protein translocase protein (TatC). Pfam-B_1212 (release 3.0). The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon  .. 
+PF01206 UPF0033; SirA;<br>Sulfurtransferase TusA. This family includes the TusA sulfurtransferases  .. 
+PF02381 UPF0040; <br>This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva & A Murzin).. 
+PF03650 UPF0041;<br>Uncharacterised protein family (UPF0041). 
+PF03668 UPF0042; ATP_bind2; <br>P-loop ATPase protein family. This family contains an ATP-binding site and could be an ATPase (personal obs:C Yeats).. 
+PF01985 UPF0044;<br>CRS1 / YhbY (CRM) domain. Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly.  GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants  .  A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing  .\.      In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity.  These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes  .  YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome   .. 
+PF01894 Uncharacterised protein family UPF0047<br>This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.. 
+PF01458 Uncharacterized protein family (UPF0051)<br>Prodom_3219 (release 99.1). 
+PF01933 Uncharacterised protein family UPF0052<br>
+PF02130 Uncharacterized protein family UPF0054<br>
+PF01679 UPF0057;<br>Proteolipid membrane potential modulator. Pfam-B_2192 (release 4.1). Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.. 
+PF01893 Uncharacterised protein family UPF0058<br>This archaebacterial protein has no known function.. 
+PF02694 Uncharacterised BCR, YnfA/UPF0060 family<br>
+PF02696 Uncharacterized ACR, YdiU/UPF0061 family<br>
+PF03401 UPF0065; Bug;<br>Tripartite tricarboxylate transporter family receptor. Pfam-B_3343 (release 6.6). These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria  .  This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families  . The TctABC system has been characterised in S. typhimurium  , and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria  .. 
+PF01980 Uncharacterised protein family UPF0066<br>
+PF03006 UPF0073; <br>Haemolysin-III related. Pfam-B_1581 (release 6.4). Members of this family are integral membrane proteins.  This family includes a protein with hemolytic activity from Bacillus cereus  . It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism  . In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins  . The mammalian members include progesterone binding proteins  . Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.. 
+PF02082 UPF0074; <br>Transcriptional regulator. This family is related to Pfam:PF001022 and other transcription regulation families (personal obs: Yeats C).. 
+PF03702 Uncharacterised protein family (UPF0075)<br>The proteins is this family are about 370 amino acids long and have no known function.. 
+PF02367 Uncharacterised P-loop hydrolase UPF0079<br>This uncharacterised family contains a P-loop.. 
+PF03652 Uncharacterised protein family (UPF0081)<br>
+PF01868 DUF49;<br>Domain of unknown function UPF0086. This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease P protein subunit p29 proteins.. 
+PF03007 UPF0089;<br>Wax ester synthase-like Acyl-CoA acyltransferase domain. Pfam-B_1896 (release 6.4). This domain is found in wax ester synthase genes such as Swiss:Q8GGG1. In these proteins this domain catalyses the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters  .. 
+PF03653 Uncharacterised protein family (UPF0093)<br>
+PF02016 UPF0094; Peptidase_U61; <br>Muramoyl-tetrapeptide carboxypeptidase hydrolyses a peptide bond between a di-basic amino acid and the C-terminal D-alanine in the tetrapeptide moiety in peptidoglycan. This cleaves the bond between an L- and a D-amino acid.\.       The function of this activity is in murein recycling. This family also includes the microcin c7 self-immunity protein Swiss:Q47511. This family corresponds to Merops family S66.. 
+PF01981 DUF119;UPF0099; Pep-tRNA_hydrol; <br>Peptidyl-tRNA hydrolase PTH2. Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation.. 
+PF02021 Uncharacterised protein family UPF0102<br>The function of this family is unknown.. 
+PF01875 DUF52; UPF0103; <br>This family contains members from all branches of life.  The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family  . It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton  .. 
+PF03706 Uncharacterised protein family (UPF0104)<br>This family of proteins are integral membrane proteins.  These proteins are uncharacterised but contain a conserved PG motif. Some members of this family are annotated as dolichol-P-glucose synthetase and contain a Pfam:PF00535 domain.. 
+PF03656 UPF0108; <br>The Pam16 protein (Swiss:P42949) is the fifth essential subunit of the pre-sequence translocase-associated protein import motor (PAM)  .  In Saccharomyces cerevisiae, Pam16 is required for preprotein translocation into the matrix, but not for protein insertion into the inner membrane  .  Pam16 has a degenerate J domain.  J-domain proteins play important regulatory roles as co-chaperones, recruiting Hsp70 partners and accelerating the ATP-hydrolysis step of the chaperone cycle  .  Pam16's J-like domain strongly interacts with Pam18's J domain, leading to a productive interaction of Pam18 with mtHsp70 at the mitochondria import channel  .  Pam18 stimulates the ATPase activity of mtHsp70.. 
+PF03657 Uncharacterised protein family (UPF0113)<br>
+PF03350 Uncharacterized protein family, UPF0114<br>Pfam-B_3587 (release 6.5) & Pfam-B_10597 (release 10.0). 
+PF01594 DUF20; <br>Domain of unknown function DUF20. Pfam-B_495 (release 4.1). This transmembrane region is found in putative permeases and  predicted transmembrane proteins it has no known function. It is not clear what source suggested that these proteins may be permeases and this information should be treated with caution.. 
+PF03715 UPF0120; <br>At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus  . It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for  ribosome nucleus export  . This family was formerly known as UPF0120.. 
+PF03661 Uncharacterised protein family (UPF0121)<br>Uncharacterised integral membrane protein family.. 
+PF04297 Putative helix-turn-helix protein, YlxM / p13 like<br>Members of this family are predicted to contain a helix-turn-helix motif,  for example residues 37-55 in Mycoplasma mycoides p13 (Swiss:O05290). Genes encoding family members are often part of operons that encode  components of the SRP pathway, and this protein may regulate the expression of an operon related to the SRP pathway  .. 
+PF03660 UPF0123; <br>This family of proteins the superfamily of PHD-finger proteins. At least one example, from mouse,  may act as a chromatin-associated protein . The S. pombe ini1 gene is essential, required for splicing  . It is localised in the nucleus, but not detected in the nucleolus and can be complemented by human ini1  .. 
+PF03658 UPF0125;<br>RnfH family Ubiquitin. A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly co-occur in two distinct gene neighborhood  contexts. In one it is associated with a START domain protein, a  membrane protein SmpA and the transfer mRNA binding protein SmpB.  This association suggests a possible role in the SmpB-tmRNA-based  tagging and degadation system of bacteria, which is interesting given that other members of the ubiquitin system are analogously involved  in protein-tagging and degradation across eukaryotes and various  prokaryotes. The second context in which the RnfH genes are present  is in a  membrane associated complex involved in transporting  electrons for various reductive reactions such as nitrogen  fixation  .. 
+PF03458 UPF0126 domain<br>Domain always found as pair in bacterial membrane proteins of unknown function. This domain contains three transmembrane helices. The conserved glycines are suggestive of  an ion channel (C. Yeats unpublished obs.).. 
+PF03673 Uncharacterised protein family (UPF0128)<br>The members of this family are about 240 amino acids in length.  The proteins are as yet uncharacterised.. 
+PF03647 UPF0136; TMEM14; <br>Transmembrane proteins 14C. Pfam-B_2984 (release 7.0). This family of short membrane proteins are as yet uncharacterised.. 
+PF03677 Uncharacterised protein family (UPF0137)<br>This family includes GP6-D a virulence plasmid encoded protein.. 
+PF03669 Uncharacterised protein family (UPF0139)<br>
+PF03686 Uncharacterised protein family (UPF0146)<br>The function of this family of proteins is unknown.. 
+PF03685 Uncharacterised protein family (UPF0147)<br>This family of small proteins have no known function.. 
+PF03695 Uncharacterised protein family (UPF0149)<br>The protein in this family are about 190 amino acids long.  The function of these proteins is unknown.. 
+PF03681 Uncharacterised protein family (UPF0150)<br>This family of small proteins is uncharacterised. In Swiss:Q9A3L8 this domain is found next to a DNA binding helix-turn-helix domain Pfam:PF01402, which suggests that this is some kind of ligand binding domain. The structure of this domain suggests that these domains oligomerise and due to structural similarities may bind to RNA. The monomer adopts an alpha-beta-beta-beta-alpha fold and forms a homotetramer. Based on the properties and functions of structural homologues of the HB8 monomer, the protein is speculated to be involved in RNA metabolism, including RNA binding and cleavage  .. 
+PF03692 UPF0153; FliB;<br>Putative zinc- or iron-chelating domain. This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex.  However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.. 
+PF03672 Uncharacterised protein family (UPF0154)<br>This family contains a set of short bacterial proteins of unknown function.. 
+PF03693 Uncharacterised protein family (UPF0156)<br>This family of proteins are about 80 amino acids in length and their function is unknown. The proteins contain a conserved GRY motif. This family appears to be related to ribbon-helix-helix DNA-binding proteins.. 
+PF04229 UPF0157;<br>This family has been suggested to belong to the nucleotidyltransferase superfamily  .  It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme  .. 
+PF03682 Uncharacterised protein family (UPF0158)<br>
+PF03690 Uncharacterised protein family (UPF0160)<br>This family of proteins contains a large number of metal binding residues. The patterns are suggestive of a phosphoesterase function.  The  conserved DHH motif may mean this family is related to Pfam:PF01368.. 
+PF03687 Uncharacterised protein family (UPF0164)<br>This family of uncharacterised proteins are only found in Treponema pallidum. They contain a putative signal peptide so may be secreted proteins.. 
+PF03691 Uncharacterised protein family (UPF0167)<br>The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.. 
+PF03666 UPF0171;<br>Nitrogen Permease regulator of amino acid transport activity 3. This family, also known in yeasts as Rmd11, complexes with NPR2, Pfam:PF06218. This complex heterodimer is responsible for inactivating TORC1. an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation.. 
+PF03665 Uncharacterised protein family (UPF0172)<br>In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus  . This family was formerly known as UPF0172.. 
+PF02476 US2 family<br>Pfam-B_2256 (release 5.4). This is a family of unique short (US) region proteins from the  herpesvirus strain. The US2 family have no known function. . 
+PF03683 Uncharacterised protein family (UPF0175)<br>This family contains small proteins of unknown function.. 
+PF03698 Uncharacterised protein family (UPF0180)<br>The members of this family are small uncharacterised proteins.. 
+PF03701 Uncharacterised protein family (UPF0181)<br>This family contains small proteins of about 50 amino acids of unknown function.\.       The family includes YoaH Swiss:P76260.. 
+PF03670 Uncharacterised protein family (UPF0184)<br>
+PF04050 Up-frameshift suppressor 2 <br>Pfam-B_14721 (release 7.3);. Transcripts harbouring premature signals for translation termination  are recognised and rapidly degraded by eukaryotic cells through a  pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3)  are required for nonsense-mediated mRNA decay  .. 
+PF01255 UPF0015;UPP_synthetase; <br>Putative undecaprenyl diphosphate synthase. Previously known as uncharacterized protein family UPF0015, a single member of this family Swiss:O82827 has been identified as an undecaprenyl diphosphate synthase  .. 
+PF00449 urease; <br>Urease alpha-subunit, N-terminal domain. The N-terminal domain is a composite domain and plays a major  trimer stabilising role by contacting the catalytic domain of the symmetry related alpha-subunit.. 
+PF00699 Urease beta subunit<br>Pfam-B_405 (release 2.1). This subunit is known as alpha in Heliobacter.. 
+PF00547 urease_gamma; <br>Urease, gamma subunit. Urease is a nickel-binding  enzyme that  catalyses the hydrolysis of  urea  to  carbon  dioxide and ammonia.. 
+PF01774 UreD urease accessory protein<br>Pfam-B_1109 (release 4.2). UreD is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid  . UreD is involved in  activation of the urease enzyme via the UreD-UreF-UreG-urease complex   and is required for urease nickel metallocenter assembly  .  See also UreF Pfam:PF01730, UreG Pfam:PF01495. . 
+PF05194 UreE urease accessory protein, C-terminal domain<br>Pfam-B_6279 (release 6.1). UreE is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.. 
+PF01730 UreF<br>Pfam-B_2037 (release 4.1). This family consists of the Urease accessory protein  UreF. The urease enzyme (urea amidohydrolase) hydrolyses urea into ammonia and carbamic acid  .  UreF is proposed to modulate the activation process of urease by eliminating the binding of nickel irons to  noncarbamylated protein  .. 
+PF04115 Ureidoglycolate hydrolase <br>Pfam-B_9183 (release 7.3);. Ureidoglycolate hydrolase (EC:3.5.3.19) carried out the third step in the degradation of allantoin.. 
+PF01014 Uricase<br>Pfam-B_1333 (release 3.0). 
+PF01208 Uroporphyrinogen decarboxylase (URO-D)<br>
+PF01175 Urocanase<br>
+PF02083 Urotensin II<br>
+PF02393 US22 like<br>Pfam-B_1016 (release 5.2). US22 proteins have been found across many animal DNA viruses and some vertebrates  . The name sake of this family US22  Swiss:P09722 is an early nuclear protein that is secreted from  cells  .  The US22 family may have a role in virus replication  and pathogenesis  . Domain analysis showed that US22 proteins\.       usually contain two copies of conserved modules which is  homologous to several other families like SMI1 and SYD (commonly  called SUKH superfamily)  . Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins  . . 
+PF00577 Outer membrane usher protein<br>MRC-LMB Genome group and Prosite. In Gram-negative bacteria the biogenesis of fimbriae (or pili) requires a two- component assembly and transport system which is composed of a periplasmic chaperone and an outer membrane protein which has been termed a molecular 'usher' [1-3].  The usher protein is rather large (from 86 to 100 Kd) and seems to be mainly composed of membrane-spanning beta-sheets, a structure reminiscent of porins. Although the degree of sequence similarity of these proteins is not very high they share a number of characteristics. One of these is the presence of two pairs of cysteines, the first one located in the N-terminal part and the second at the C-terminal extremity that are probably involved in disulphide bonds. The best conserved region is located in the central part of these proteins [4-5].. 
+PF04871 Uso1 / p115 like vesicle tethering protein, C terminal region<br>Pfam-B_6073 (release 7.6). Also known as General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region  .  p115  tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal  acidic region.  It is required for intercisternal transport in the golgi stack. This family consists of the acidic C-terminus, which binds to the golgins giantin and GM130.  p115 is thought to juxtapose two membranes by binding giantin with one acidic region, and GM130 with another  .. 
+PF04869 Uso1 / p115 like vesicle tethering protein, head region<br>Pfam-B_6073 (release 7.6). Also known as General vesicular transport factor, Transcytosis associated protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region  .  p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region.  It is required for intercisternal transport in the golgi stack.\. This family consists of part of the head region. The head region is highly conserved, but its function is unknown.  It does not seem to be essential for vesicle tethering  .  The N-terminal part of the head region, not within this family, contains context-detected Armadillo/beta-catenin-like repeats (Pfam:PF00514).. 
+PF00582 Universal stress protein family<br>MRC-LMB Genome group. The universal stress protein UspA Swiss:P28242    is a small cytoplasmic  bacterial protein whose expression  is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during  prolonged exposure to such conditions, and may provide a general "stress endurance" activity.  The crystal structure of Haemophilus influenzae UspA   reveals  an  alpha/beta fold similar to that of the Methanococcus jannaschii  MJ0577 protein, which binds ATP  , though UspA lacks ATP-binding activity.. 
+PF03253 Urea transporter<br>Pfam-B_3193 (release 6.5). Members of this family transport urea across membranes. The family includes a bacterial homologue Swiss:Q9S408. . 
+PF01099 Uterglobin; <br>Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be  elucidated  .. 
+PF03998 Utp11 protein<br>Pfam-B_6404 (release 7.3). This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA  . Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome  .. 
+PF04003 Dip2/Utp12 Family<br>Pfam-B_10105 (release 7.3). This domain is found at the C-terminus of proteins containing WD40 repeats.  These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2 Swiss:Q12220  .. 
+PF04615 Utp14 protein<br>Pfam-B_5404 (release 7.4). This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA  . Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome  .. 
+PF03851 UV-endonuclease UvdE<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00580 UvrD/REP helicase N-terminal domain<br>MRC-LMB Genome group.. The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.. 
+PF02614 Glucuronate isomerase<br>This is a family of Glucuronate isomerases also known as D-glucuronate  isomerase, uronic isomerase, uronate isomerase, or uronic acid isomerase, EC:5.3.1.12.  This enzyme catalyses the reactions: D-glucuronate <=>  D-fructuronate and D-galacturonate <=> D-tagaturonate.  It is not however  clear where the experimental evidence for this functional assignment came from and thus this family has no literature reference.. 
+PF03786 D-mannonate dehydratase (UxuA)<br>UxuA (this family) and UxuB are required for hexuronate degradation.. 
+PF03223 V-ATPase subunit C<br>Pfam-B_2945 (release 6.5). 
+PF03179 Vacuolar (H+)-ATPase G subunit<br>Pfam-B_1274 (release 6.5). This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialised cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.. 
+PF03224 V-ATPase_H; <br>Pfam-B_2481 (release 6.5). The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer.  This domain corresponds to the N terminal domain of the H subunit of V-ATPase.  The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation  .. 
+PF01639 Viral family 110<br>Pfam-B_1518 (release 4.1). This family of viral proteins is known as the 110 family  . The function of members of this family is unknown. The family contains a central cysteine rich region with eight conserved cysteines. Some members of the family contains two copies of the cysteine rich region Swiss:P18560. . 
+PF03402 Vomeronasal organ pheromone receptor family, V1R<br>Pfam-B_3057 (release 6.6). This family represents one of two known vomeronasal organ receptor families, the V1R family (after  ).. 
+PF02830 V4R domain<br>The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons  .. 
+PF01496 V_ATPase_sub_a; <br>V-type ATPase 116kDa subunit family  . Pfam-B_446 (release 4.0). This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i.  The V-type ATPases family are proton pumps that acidify intracellular compartments  in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes  .  The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices  it has a hydrophilic amino terminal and a hydrophobic carboxy  terminal [1,2]. It has roles in proton transport and assembly of the V-type ATPase complex [1,2].  This subunit is encoded by two homologous gene in yeast VPH1 and STV1  .. 
+PF02346 Chordopoxvirus fusion protein<br>Pfam-B_822 (release 5.2). This is a family of viral fusion proteins from the chordopoxviruses. Swiss:P26312 a 14-kDa Vaccinia Virus protein  has been demonstrated to function as a viral fusion protein mediating  cell fusion at endosmomal (low) pH  .. 
+PF02691 Vacuolating cyotoxin<br>Pfam-B_436 (release 5.5). This family consists of Vacuolating cyotoxin proteins form Proteobacteria. These proteins are an important virulence determinate in H. pylori and induce cytoplasmic vacuolation in a variety of mammalian cell lines  .. 
+PF03077 VACA; <br>Putative vacuolating cytotoxin. Pfam-B_2866 (release 6.4). This family contains a number of Helicobacter outer membrane proteins with multiple copies of this small conserved region.. 
+PF04333 VacJ like lipoprotein<br>VacJ is required for the intercellular spreading of Shigella flexneri. It is attached to the outer membrane by a lipid anchor  .. 
+PF04294 VanW like protein<br>Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin  resistance gene clusters vanB   and vanG  .  The function of VanW is  unknown.. 
+PF02557 D-alanyl-D-alanine carboxypeptidase<br>
+PF04892 VanZ like family <br>Pfam-B_5529 (release 7.6). This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases  .. 
+PF03490 Variant-surface-glycoprotein phospholipase C<br>
+PF01992 ATP synthase (C/AC39) subunit<br>This family includes the AC39 subunit from vacuolar ATP synthase Swiss:P32366  , and the C subunit from archaebacterial ATP synthase  .  The family also includes subunit C from the Sodium transporting ATP synthase from Enterococcus hirae Swiss:P43456  .. 
+PF01991 ATP synthase (E/31 kDa) subunit<br>This family includes the vacuolar ATP synthase E subunit  , as well as the archaebacterial ATP synthase E subunit  .. 
+PF01505 Major Vault Protein repeat<br>The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function  . This family corresponds to a repeat found in the amino terminal half of the major vault protein.. 
+PF01847 von Hippel-Lindau disease tumour suppressor protein<br>VHL forms a ternary complex with the elonginB  Swiss:O44226 and elonginC Swiss:O13292 proteins. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor Swiss:P15692 mRNA.. 
+PF02209 Villin headpiece domain<br>Alignment kindly provided by SMART. 
+PF04702 Vicilin N terminal region<br>This region is found in plant seed storage proteins, N-terminal to the Cupin domain (Pfam:PF00190). In Macadamia integrifolia (Swiss:Q9SPL4), this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif.  These peptides exhibit antimicrobial activity in vitro  .. 
+PF00559 Retroviral Vif (Viral infectivity) protein<br>Human immunodeficiency virus type 1 (HIV-1) Vif is required for  productive infection of T lymphocytes and macrophages. Virions  produced in the absence of Vif have abnormal core morphology and  those produced in primary T cells carry immature core proteins  and low levels of mature capsid.. 
+PF01044 Vinculin family<br>Pfam-B_1420 (release 3.0). 
+PF02236 Vir_DNA_binding; <br>Viral DNA-binding protein, all alpha domain. Pfam-B_1651 (release 5.2). This family represents a domain of the viral DNA- binding protein, a multi functional protein involved in DNA  replication and transcription control.. 
+PF03728 Vir_DNA_Zn_bind; <br>Viral DNA-binding protein, zinc binding domain. Pfam-B_1651 (release 5.2). This family represents the zinc binding domain of the viral DNA- binding protein, a multi functional protein involved in DNA  replication and transcription control.  Two copies of this domain  are found at the C-terminus of many members of the family.. 
+PF00426 VP4;<br>Outer Capsid protein VP4 (Hemagglutinin). Pfam-B_161 (release 1.0). 
+PF03225 Vir_Hsp90; <br>Viral heat shock protein Hsp90 homologue . Pfam-B_2880 (release 6.5). 
+PF04530 Viral Beta C/D like family<br>Pfam-B_4973 (release 7.5). Family of ssRNA positive-strand viral proteins.  Conserved region found in the Beta C and Beta D transcripts.. 
+PF00729 Viral coat protein (S domain)<br>Pfam-B_870 (release 2.1). 
+PF00747 viral_DNA_bp; <br>ssDNA binding protein. Pfam-B_490 (release 2.1). This protein is found in herpesviruses and is needed for replication.. 
+PF01443 Viral (Superfamily 1) RNA helicase<br>Prodom_1256 (release 99.1). Helicase activity for this family has been demonstrated   and NTPase activity  . This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis  .. 
+PF04521 ssRNA positive strand viral 18kD cysteine rich protein<br>Pfam-B_2612 (release 7.5). 
+PF00998 HCV_RdRP; Viral_RdRP; <br>Viral RNA dependent RNA polymerase. Pfam-B_315 (release 3.0). This family includes viral RNA dependent RNA polymerase enzymes from hepatitis C virus and various plant viruses.. 
+PF02407 Putative viral replication protein<br>Pfam-B_1223 (release 5.2). This is a family of viral ORFs from various plant and animal ssDNA circoviruses.  Published evidence to  support the annotated function "viral replication  associated protein" has not be found.. 
+PF05101 Type IV secretory pathway, VirB3-like protein<br>This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes  . The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins  .. 
+PF04335 VirB8 protein<br>Pfam-B_1984 (release 7.3). VirB8 is a bacterial virulence protein with cytoplasmic, transmembrane, and periplasmic regions. It is thought that it is a primary constituent of a DNA transporter. The periplasmic region interacts with VirB9, VirB10, and itself  . This family also includes the conjugal transfer protein family TrbF, a family of proteins known to be involved in conjugal transfer.  The TrbF protein is thought to compose part of the pilus required for transfer  . This domain has a similar fold to the NTF2 protein.. 
+PF00286 virus_P-coat; Virus_P-coat; <br>Family includes coat proteins from Potexviruses and carlaviruses.. 
+PF01347 Lipoprotein amino terminal region<br>Pfam-B_1280 (release 3.0). This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100.  These proteins are all involved in lipid transport  . This family contains the LV1n chain from lipovitellin, that contains two structural domains.. 
+PF05090 Vitamin K-dependent gamma-carboxylase<br>Pfam-B_6307 (release 7.7). Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl  carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase  .. 
+PF04649 Mycoplasma hyorhinis VlpA repeat <br>This repeat is found in the extracellular (C-terminal) region of the  variant surface antigen A (VlpA) of Mycoplasma hyorhinis. Mutations that change the number of repeats in the protein are involved in antigenic variation and immune evasion of this swine pathogen  .. 
+PF01660 Viral methyltransferase<br>This RNA methyltransferase domain   is found in a wide range of ssRNA viruses, including Hordei-, Tobra-, Tobamo-, Bromo-, Clostero- and Caliciviruses.  This methyltransferase is involved in mRNA capping.  Capping of mRNA enhances its stability. This usually occurs in the nucleus.  Therefore, many viruses that replicate in the cytoplasm encode their own  .  This is a specific guanine-7-methyltransferase domain involved in viral mRNA cap0 synthesis. Specificity for guanine 7 position is shown by NMR in   and in vivo role in cap synthesis  .  Based on secondary structure prediction, the basic fold is believed to be similar to the common AdoMet-dependent methyltransferase fold  . A curious feature of this methyltransferase domain is that it together with flanking sequences seems to have guanylyltransferase activity coupled to the methyltransferase activity  . The domain is found throughout the so-called Alphavirus superfamily, (including alphaviruses and several other groups). It forms the defining, unique feature of this superfamily  .. 
+PF00695 Major surface antigen from hepadnavirus<br>Pfam-B_168 (release 2.1). 
+PF03762 Vitelline membrane outer layer protein I (VOMI) <br>Pfam-B_3481 (release 7.0). VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure   that consists of three beta-sheets forming Greek  key motifs, which are related by an internal pseudo three-fold  symmetry. Furthermore, the structure of VOMI has strong similarity  to the structure of the delta-endotoxin, as well as a  carbohydrate-binding site in the top region of the common fold  . . 
+PF00434 Glycoprotein VP7<br>Pfam-B_116 (release 1.0). 
+PF00522 VPR/VPX protein<br>Pfam-B_100 (release 1.0). 
+PF03643 Vacuolar protein sorting-associated protein 26 <br>Pfam-B_4396 (release 7.0). Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking.  In particular, Vps26  assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35  . This family also contains Down syndrome critical region 3/A.. 
+PF03997 VPS28 protein<br>Pfam-B_6317 (release 7.3). 
+PF04133 Vacuolar protein sorting 55 <br>Pfam-B_25168 (release 7.3);. Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase.  Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells  .. 
+PF00558 Vpu protein<br>The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing  the release of viral particles from infected cells. The VPU protein binds specifically to CD4.. 
+PF03852 DNA mismatch endonuclease Vsr<br>TIGRFAMs, Griffiths-Jones SR. 
+PF00093 vwc; <br>von Willebrand factor type C domain. The high cutoff was used to prevent overlap with Pfam:PF00094.. 
+PF02020 IF5_eIF4_eIF2;<br>eIF4-gamma/eIF5/eIF2-epsilon. This domain of unknown function is found at the C-terminus of several translation initiation factors  .. 
+PF03716 WCCH_motif; <br>Pfam-B_3194 (release 7.0). The WCCH motif is found in a retrotransposons and Gemini viruses. A specific function has not been associated to this motif  .. 
+PF00458 WHEP-TRS domain<br>
+PF00110 wnt family<br>Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families  .. 
+PF01822 WSC domain<br>This domain may be involved in carbohydrate binding.. 
+PF02165 Wilm's tumour protein<br>
+PF03303 WTF protein<br>Pfam-B_4183 (release 6.5). This is a family of hypothetical Schizosaccharomyces pombe proteins. Their function is unknown.. 
+PF04932 O-Antigen ligase<br>Pfam-B_5033 (release 7.6). This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL  .. 
+PF00739 Trans-activation protein X<br>Pfam-B_458 (release 2.1). This protein is found in hepadnaviruses where it is indispensable for replication.. 
+PF00860 xan_ur_permease; <br>Pfam-B_1593 (release 2.1). This family includes permeases for diverse substrates such as xanthine Swiss:P42086, uracil Swiss:P39766 and vitamin C Swiss:Q9UGH3.  However many members of this family are functionally uncharacterised and may transport other substrates. Members of this family have ten predicted transmembrane helices.. 
+PF04921 XAP5, circadian clock regulator<br>Pfam-B_4702 (release 7.6). This protein is found in a wide range of eukaryotes. It is a nuclear protein and is suggested to be DNA binding [1,2]. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light  .. 
+PF02625 DUF182; <br>XdhC and CoxI family. This domain is often found in association with an NAD-binding region, related to TrkA-N (Pfam:PF02254; personal obs:C. Yeats). XdhC is  believed to be involved in the attachment of molybdenum to Xanthine Dehydrogenase ( ).. 
+PF03894 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase<br>Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22  . This family is distantly related to transketolases e.g. Pfam:PF02779.. 
+PF03469 XH domain<br>The XH (rice gene X Homology) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2.  The molecular function of these proteins is unknown.  However these proteins usually contain an XS domain that is also found in the PTGS protein SGS3. This domain contains a conserved glutamate residue that may be functionally important.. 
+PF03468 XS domain<br>The XS (rice gene X and SGS3) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2 and SGS3 Swiss:Q9LDX1.  SGS3 is thought to be involved in post-transcriptional gene silencing (PTGS). This domain contains a conserved aspartate residue that may be functionally important. The XS domain has recently been predicted to possess an RRM-like RNA-binding domain   by fold recognition.. 
+PF04555 Restriction endonuclease XhoI<br>This family consists of type II restriction enzymes (EC:3.1.21.4) that recognise the double-stranded sequence CTCGAG and cleave after C-1.. 
+PF00193 Extracellular link domain<br>Swissprot_feature_table. 
+PF00867 XPG I-region<br>Pfam-B_776 (release 3.0). 
+PF00752 XPG N-terminal domain<br>Pfam-B_491 (release 2.1). 
+PF01834 XRCC1 N terminal domain<br>
+PF02162 Rhodopsin_C; <br>XYPPX repeat (two copies). This repeat is found in a wide variety of proteins and generally consists of the motif XYPPX where X can be any amino acid. The family includes annexin VII Swiss:P24639, the carboxy tail of certain rhodopsins Swiss:Q17094. This family also includes plaque matrix proteins, however this motif is embedded in a ten residue repeat in Swiss:Q25460. The molecular function of this repeat is unknown. It is also not clear is all the members of this family share a common evolutionary ancestor due to its short length and biased amino acid composition.. 
+PF04690 YABBY protein<br>Pfam-B_5698 (release 7.5). YABBY proteins are a group of plant-specific transcription involved in the specification of abaxial polarity in lateral organs [1,2].. 
+PF03895 YadA; YadA_C;<br>YadA-like C-terminal region. This region represents the C-terminal 120 amino acids of a family of surface-exposed bacterial proteins. YadA, an adhesin from Yersinia, was the first member of this family to be characterised. UspA2 from Moraxella was second. The Eib immunoglobulin-binding proteins from E. coli were third, followed by the DsrA proteins of Haemophilus ducreyi and others. These proteins are homologous at their C-terminal and have predicted signal sequences, but they diverge elsewhere. The C-terminal 9 amino acids, consisting of alternating hydrophobic amino acids ending in F or W, comprise a targeting motif for the outer membrane of the Gram negative cell envelope. This region is important for oligomerisation  .. 
+PF02699 DUF219; <br>Preprotein translocase subunit. 
+PF04073 YbaK;<br>Aminoacyl-tRNA editing domain. This domain is found either on its own or in association with the tRNA synthetase class II core domain (Pfam:PF00587).  It is involved in the tRNA editing of mis-charged tRNAs including Cys-tRNA(Pro), Cys-tRNA(Cys), Ala-tRNA(Pro)[2-5].  The structure of this domain shows a novel fold  .. 
+PF02392 Ycf4<br>Pfam-B_1026 (release 5.2). This family consists of hypothetical Ycf4 proteins from various chloroplast genomes.  It has been suggested that Ycf4 is involved in the assembly and/or stability of the photosystem I complex in chloroplasts  .. 
+PF01737 YCF9; <br>Pfam-B_2211 (release 4.1). This family consists of the hypothetical protein product of the YCF9 gene from chloroplasts and  cyanobacteria. These proteins have no known function.. 
+PF03795 YCII-related domain<br>
+PF02182 G9a; YDG_SRA;<br>Iyer LM, Aravind L, SMART. Alignment kindly provided by SMART. The domain goes by several names including SAD  , SRA    and  YDG  . It adopts a beta barrel, modified PUA-like, fold that is  widely present in eukaryotic chromatin proteins and in bacteria  . Versions of this domain are known to bind hemi-methylated CpG  dinucleotides and also other 5mC containing dinucleotides. The  domain binds DNA by flipping out the methylated cytosine base from  the DNA double helix  .The conserved tyrosine and aspartate  residues and a glycine rich patch are critical for recognition of  the flipped out base   . Mammalian UHRF1 that contains this  domain plays an important role in maintenance of methylation at  CpG dinucleotides by recruiting DNMT1 to hemimethylated sites\. associated with replication forks  . The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA  methylation to chromatin-protein ubiquitination  . The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions  . A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains  . In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or\. hemi-methylated DNA  .. 
+PF04794 YdjC-like protein<br>Pfam-B_5925 (release 7.5). Family of YdjC-like proteins.  This region is possibly involved in the the cleavage of cellobiose-phosphate  .. 
+PF00399 yeast_PIR; <br>Yeast PIR protein repeat. 
+PF03366 YEATS family<br>Pfam-B_2273 (release 6.6). We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity. 
+PF03543 YerHae_surfAg; SurfAg;<br>Yersinia/Haemophilus virulence surface antigen. 
+PF03545 Yers_vir_YopE; <br>Yersinia virulence determinant (YopE). 
+PF03887 YfbU domain<br>This presumed domain is about 160 residues long.  It is found in archaebacteria and eubacteria.  In Swiss:Q9EUM2 it is associated with a helix-turn-helix domain. This suggests that this may be a ligand binding domain.. 
+PF02542 YgbB family<br>The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis)  .. 
+PF02325 YGGT family<br>Pfam-B_983 (release 5.2). This family consists of a repeat found in conserved hypothetical integral membrane proteins.  The function of this region and the proteins which possess it is unknown.. 
+PF04945 YHS domain<br>This short presumed domain is about 50 amino acid residues long.  It often contains two cysteines that may be functionally important.  This domain is found in copper transporting ATPases, some phenol hydroxylases and in a set of uncharacterised membrane proteins including Swiss:Q9CNI0. This domain is named after three of the most conserved amino acids it contains.  The domain may be metal binding, possibly copper ions. This domain is duplicated in some copper transporting ATPases.. 
+PF03755 YicC_N-term; <br>YicC-like family, N-terminal region . Pfam-B_3743 (release 7.0). Family of bacterial proteins. Although poorly characterised, the members of this protein family have been demonstrated to play a role in stationary phase survival  . These proteins are  not essential during stationary phase  .. 
+PF03853 YjeF-related protein N-terminus<br>TIGRFAMs, Griffiths-Jones SR. YjeF-N domain is a novel version of the Rossmann fold with a set of  catalytic residues and structural features that are different from the conventional dehydrogenases  . YjeF-N domain is fused to  Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and  FLJ21128)  , where they may be involved in decapping and catalyze  hydrolytic RNA-processing reactions  .. 
+PF03739 Predicted permease YjgP/YjgQ family<br>Members of this family are predicted integral membrane proteins of unknown function.\.     They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.. 
+PF02326 Plant ATP synthase F0<br>Pfam-B_984 (release 5.2). This family corresponds to subunit 8 (YMF19) of the F0 complex of plant and algae mitochondrial F-ATPases (EC:3.6.1.34).. 
+PF01514 Secretory protein of YscJ/FliF family<br>Pfam-B_736 (release 4.0). This family includes proteins that are related to the YscJ lipoprotein, and the amino terminus of FliF, the flageller M-ring protein.  The members of the YscJ family are thought to be involved in secretion of several proteins.\.     The FliF protein ring is thought to be part of the export apparatus for flageller proteins, based on the similarity to YscJ proteins  .. 
+PF04650 YSIRK type signal peptide<br>Pfam-B_3441 (release 7.5). Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology.  There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.. 
+PF02295 Adenosine deaminase z-alpha domain<br>Pfam-B_11136 (release 5.2). This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric  hindrance  .  . 
+PF01559 Zein seed storage protein<br>Pfam-B_181 (release 4.0). Zeins are seed storage proteins. They are unusually rich in glutamine, proline, alanine, and leucine residues and their sequences show a series of tandem repeats  .. 
+PF01754 A20-like zinc finger<br>The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain [5-6]. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.. 
+PF01428 AN1-like Zinc finger<br>Zinc finger at the C-terminus of An1 Swiss:Q91889, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.. 
+PF00096 Zinc finger, C2H2 type<br>The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter  .. 
+PF00105 Zinc finger, C4 type (two domains)<br>In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.. 
+PF01396 Topoisomerase DNA binding C4 zinc finger<br>Pfam-B_1854 (release 3.0). 
+PF02928 C5HC2 zinc finger<br>Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji  . This domain may have a DNA binding function.. 
+PF01807 CHC2 zinc finger<br>Pfam-B_755 (release 4.2). This domain is principally involved in DNA binding in DNA primases.. 
+PF05207 CSL zinc finger<br>Pfam-B_12353 (release 7.7). This is a zinc binding motif which contains four cysteine residues which chelate zinc  .  This domain is often found associated with a Pfam:PF00226 domain.  This domain is named after the conserved motif of the final cysteine.. 
+PF05180 DNL zinc finger<br>Pfam-B_9925 (release 7.7). The domain is named after a short C-terminal motif of D(N/H)L. This domain is a novel zinc-finger protein essential for protein  import into mitochondria  .. 
+PF02701 Dof domain, zinc finger<br>Pfam-B_1250 (release 5.5). The Dof domain is a zinc finger DNA-binding domain, that shows resemblance to the Cys2 zinc finger  . . 
+PF04770 ZF-HD protein dimerisation region<br>Pfam-B_2002 (release 7.6). This family of proteins has are plant transcription factors, and have been  named ZF-HD for zinc finger homeodomain proteins, on the basis of  similarity to proteins of known structure  .  This region is thought to  be involved in the formation of homo and heterodimers, and may form a zinc finger  .. 
+PF01422 NF-X1 type zinc finger<br>This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA  .. 
+PF00645 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region<br>Poly(ADP-ribose) polymerase is an important regulatory component of the cellular response to DNA damage. The amino-terminal region of Poly(ADP-ribose) polymerase consists of two PARP-type zinc fingers.  This region acts as a DNA nick sensor.. 
+PF00641 Zn-finger in Ran binding protein and others<br>
+PF02135 TAZ zinc finger<br>The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1.  The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.. 
+PF02953 Tim10/DDP family zinc finger<br>Pfam-B_1207 (release 6.4). Putative zinc binding domain with four conserved cysteine residues.  This domain is found in the human disease protein Swiss:O60220.  Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import  .\.    Members of this family seem to be localised to the mitochondrial intermembrane space  .. 
+PF02176 TRAF-type zinc finger<br>
+PF02207 zf-UBR1; <br>Putative zinc finger in N-recognin (UBR box). Alignment kindly provided by SMART. This region is found in E3 ubiquitin ligases that recognise N-recognins  .. 
+PF03470 XS zinc finger domain<br>This domain is a putative nucleic acid binding zinc finger found in proteins that also contain an XS domain.. 
+PF01258 zf_dskA_traR; <br>Prokaryotic dksA/traR C4-type zinc finger. 
+PF04071 DUF379; zf_like; <br>Cysteine-rich small domain. Probable metal-binding domain.. 
+PF04354 ZipA, C-terminal FtsZ-binding domain<br>This family represents the ZipA C-terminal domain. ZipA is involved in septum formation in bacterial cell division. Its C-terminal domain binds FtsZ, a major component of the bacterial septal ring. The structure of this domain is an alpha-beta fold with three alpha helices and a beta sheet of six antiparallel beta strands. The major loops protruding from the beta sheet surface are thought to form a binding site for FtsZ  .. 
+PF00172 Fungal Zn(2)-Cys(6) binuclear cluster domain<br>
+PF00882 Zinc dependent phospholipase C<br>Pfam-B_1401 (release 3.0). 
+PF04228 Putative neutral zinc metallopeptidase<br>Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).. 
+PF04298 Putative neutral zinc metallopeptidase<br>Zinc metallopeptidase zinc binding regions have been predicted in some  family members by a pattern match (Prosite:PS00142).. 
+PF03854 ZnF_P11; <br>
+PF03367 ZPR1; <br>ZPR1 zinc-finger domain. Pfam-B_1372 (release 6.6). The zinc-finger protein ZPR1 is ubiquitous among eukaryotes. It is indeed known to be an essential protein in yeast. In quiescent cells, ZPR1 is localised to the cytoplasm. But in proliferating cells treated with EGF or with other mitogens, ZPR1 accumulates in the nucleolus. ZPR1 interacts with the cytoplasmic domain of the inactive EGF receptor (EGFR) and is thought to inhibit the basal protein tyrosine kinase activity of EGFR. This interaction is disrupted when cells are treated with EGF, though by themselves, inactive EGFRs are not sufficient to sequester ZPR1 to the cytoplasm [1,2,3]. Upon stimulation by EGF, ZPR1 directly binds the eukaryotic translation elongation factor-1alpha (eEF-1alpha) to form ZPR1/eEF-1alpha complexes  . These move into the nucleus, localising particularly at the nucleolus. Indeed, the interaction between ZPR1 and eEF-1alpha has been shown to be essential for normal cellular proliferation  , and ZPR1 is thought to be involved in pre-ribosomal RNA expression  . The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A but does not directly influence the kinetics of nucleotide exchange or GTP hydrolysis  . The alignment for this family shows a domain of which there are two copies in ZPR1 proteins. This family also includes several hypothetical archaeal proteins (from both Crenarchaeota and Euryarchaeota), which only contain one copy of the aligned region. This similarity between ZPR1 and archaeal proteins was not previously noted.. 
+PF00791 ZU5 domain<br>Alignment kindly provided by SMART. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.. 
+PF00569 Zinc finger, ZZ type<br>Alignment kindly provided by SMART. Zinc finger present in dystrophin, CBP/p300.  ZZ in dystrophin binds calmodulin.  Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure  .. 
+PF04358 DsrC like protein<br>Family member Swiss:P45573 has been observed to co-purify with  Desulfovibrio vulgaris dissimilatory sulfite reductase  , and many  members of this family are annotated as the third (gamma) subunit of  dissimilatory sulphite reductase. However, this protein appears to be only loosely associated to the  sulfite reductase, which suggests that DsrC may not be an integral part of the dissimilatory sulphite reductase.  Members of this family are found in organisms such as E. coli and H. influenzae which do not contain  dissimilatory sulphite reductases but can synthesise assimilatory sirohaem  sulphite and nitrite reductases.  It is speculated that DsrC may be  involved in the assembly, folding or stabilisation of sirohaem proteins  .  The strictly conserved cysteine in the C terminus suggests that DsrC may have a catalytic function in the metabolism of sulphur compounds  .. 
+PF04252 DUF431; <br>Predicted SAM-dependent RNA methyltransferase. This family of proteins are predicted to be alpha/beta-knot SAM-dependent RNA methyltransferases  .. 
+PF04359 Protein of unknown function (DUF493)<br>
+PF04205 FMN-binding domain<br>This conserved region includes the FMN-binding site of the NqrC protein   as well as the NosR and NirI regulatory proteins.. 
+PF04432 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus<br>Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits  ,  .  The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family  . This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).. 
+PF04609 Methyl-coenzyme M reductase operon protein C<br>Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240)  . Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D  . The function of proteins C and D (this family) is unknown. This family nowalso includes family MtrC_related,. 
+PF04607 Region found in RelA / SpoT proteins<br>This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologues in plants and in other eubacteria. RelA is a guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase (EC:2.7.6.5) while SpoT is thought to be a bifunctional enzyme catalysing both ppGpp  synthesis and degradation (ppGpp 3'-pyrophosphohydrolase, (EC:3.1.7.2))  . This region is often found in association with HD (Pfam:PF01966), a  metal-dependent phosphohydrolase, TGS (Pfam:PF02824) which is a possible  nucleotide-binding region, and the ACT regulatory domain (Pfam:PF01842).. 
+PF04226 Transglycosylase associated protein<br>Bacterial protein, predicted to be an integral membrane protein. Some family members have been annotated as transglycosylase associated proteins, but no experimental evidence is provided.  This family was annotated based on the information in Swiss:P76011.. 
+PF04264 YceI-like domain<br>E. coli YceI is a base-induced periplasmic protein  . The recent structure of a member of this family shows that it binds to polyisoprenoid  . The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.. 
+PF04431 pec_lyase_N; <br>Pectate lyase, N terminus. This region is found N terminal to the pectate lyase domain (Pfam:PF00544) in some plant pectate lyase enzymes.. 
+PF05223 NTF2-like N-terminal transpeptidase domain<br>The structure of this domain from MecA is known   Swiss:Q53707 and is found to be similar to that found in NTF2 Pfam:PF02136. This domain seems unlikely to have an enzymatic function, and its role remains unknown.. 
+PF05224 NDT80 / PhoG like DNA-binding  family<br>This family includes the DNA-binding region of NDT80   as well as PhoG and its homologues. The family contains Swiss:Q05534 or VIB-1. VIB-1 is thought to be a regulator of conidiation in Neurospora crassa and shares a region of similarity to PHOG, a possible phosphate nonrepressible acid phosphatase in Aspergillus nidulans. It has been found that vib-1 is not the structural gene for nonrepressible acid phosphatase, but rather may regulate nonrepressible acid phosphatase activity  .. 
+PF05225 helix-turn-helix, Psq domain<br>This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster  . In pipsqueak this domain binds to GAGA sequence  .. 
+PF05226 CHASE2 domain<br>CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE2 domains are not known at this time  .. 
+PF05227 CHASE3 domain<br>CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE3 domains are not known at this time  .. 
+PF05228 CHASE4 domain<br>CHASE4. This is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in prokaryotes. Specifically, CHASE4 domains are found in histidine kinases in Archaea and in predicted diguanylate cyclases/phosphodiesterases in Bacteria. Environmental factors that are recognized by CHASE4 domains are not known at this time  .. 
+PF05229 Spore Coat Protein U domain<br>This domain is found in a bacterial family of spore coat proteins  , as well as a family of secreted pili proteins involved in motility and biofilm formation ( ). This family is distantly related to fimbrial proteins.. 
+PF05230 MASE2 domain<br>Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins.. 
+PF05231 MASE1<br>Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This entry also includes members of the 8 transmembrane UhpB type (8TMR-UT) domain family  .. 
+PF05232 Bacterial Transmembrane Pair family<br>This family represents a conserved pair of transmembrane helices. It appears to be found as two tandem repeats in a family of hypothetical proteins.. 
+PF05233 PHB accumulation regulatory domain<br>The proteins this domain is found in are typically  involved in regulating polymer accumulation in bacteria, particularly poly-beta-hydroxybutyrate (PHB)  . The  N-terminal region is likely to be the DNA-binding domain (Pfam:PF07879) while this domain probably binds PHB (personal obs:C Yeats).. 
+PF05234 UAF_rrn5; <br>UAF complex subunit Rrn10. The protein Rrn10 has been identified as a component of the Upstream Activating Factor (UAF), an RNA polymerase I (pol I) specific transcription stimulatory factor  . 
+PF05235 CHAD domain<br>The CHAD domain is an alpha-helical domain functionally associated with the Pfam:PF01928 domains. It has conserved histidines that may chelate metals  .. 
+PF05236 Transcription initiation factor TFIID component TAF4 family<br>This region of similarity is found in Transcription initiation factor TFIID component TAF4  .. 
+PF05237 MoeZ/MoeB domain<br>This putative domain is found in the MoeZ protein and the MoeB protein. The domain has two CXXC motifs that are only partly conserved.. 
+PF05238 CHL4;<br>Kinetochore protein CHL4 like. CHL4 is a protein involved in chromosome segregation  . It is a component of the central kinetochore which mediates the attachment of the centromere to the mitotic spindle  . CENP-N is one of the components that assembles onto the CENP-A-nucleosome-associated (NAC) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC  .. 
+PF05239 PRC-barrel domain<br>The PRC-barrel is an all beta barrel domain found in photosystem reaction centre subunit H of the purple bacteria and RNA metabolism proteins of the RimM group. PRC-barrels are approximately 80 residues long, and found widely represented in bacteria, archaea and plants.  This domain is also present at the carboxyl terminus of the pan-bacterial protein RimM, which is involved in ribosomal maturation and processing of 16S rRNA. A family of small proteins conserved in all known euryarchaea are composed entirely of a single stand-alone copy of the domain  .. 
+PF05240 APOBEC-like C-terminal domain<br>This domain is found at the C-termini of the Apolipoprotein B mRNA editing enzyme.. 
+PF05241 Emopamil binding protein <br>Pfam-B_7320 (release 7.7). Emopamil binding protein (EBP) is as a gene that encodes a non-glycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains, including the sterol acceptor site and the catalytic centre, which show Delta8-Delta7 sterol isomerase activity. Human sterol isomerase, a homologue of mouse EBP, is suggested not only to play a role in cholesterol biosynthesis, but also to affect lipoprotein internalisation. In humans, mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities  .. 
+PF05242 Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)<br>Pfam-B_7429 (release 7.7). This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a  saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph  nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has  been shown to be a critical structural requirement to be recognised by  L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus  and rat cochlea  .. 
+PF05244 Brucella outer membrane protein 2<br>Pfam-B_7448 (release 7.7). This family consists of several outer membrane proteins (2a and 2b) from brucella bacteria. Brucellae are Gram-negative, facultative intracellular bacteria that can infect many species of animals and man  .. 
+PF05246 Protein of unknown function (DUF735)<br>Pfam-B_7611 (release 7.7). This family consists of several uncharacterised Borrelia burgdorferi (Lyme disease spirochete) proteins of unknown function.. 
+PF05247 Flagellar transcriptional activator (FlhD)<br>Pfam-B_7623 (release 7.7). This family consists of several bacterial flagellar transcriptional activator (FlhD) proteins. FlhD combines with FlhC to form a regulatory complex in E. coli, this complex has been shown to be a global regulator  involved in many cellular processes as well as a flagellar transcriptional activator  .. 
+PF05248 Adenovirus E3A<br>Pfam-B_7497 (release 7.7). 
+PF05250 Uncharacterised protein family (UPF0193)<br>This family of proteins is functionally uncharacterised.. 
+PF05251 Uncharacterised protein family (UPF0197)<br>This family of proteins is functionally uncharacterised.. 
+PF05253 UPF0224; <br>U11-48K-like CHHC zinc finger. This zinc binding domain   has four conserved zinc chelating residues in a CHHC pattern. This domain is predicted to have an RNA-binding function  .. 
+PF05254 Uncharacterised protein family (UPF0203)<br>This family of proteins is functionally uncharacterised.. 
+PF05255 Uncharacterised protein family (UPF0220)<br>This family of proteins is functionally uncharacterised.. 
+PF05256 Uncharacterised protein family (UPF0223)<br>This family of proteins is functionally uncharacterised.. 
+PF05257 AXE; <br>Pfam-B_2845 (release 7.7). This domain corresponds to an amidase function.  Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where is functions as a glutathionylspermidine amidase EC:3.5.1.78  . This domain is found to be the catalytic domain of PlyCA  .. 
+PF05258 Protein of unknown function (DUF721)<br>Pfam-B_7527 (release 7.7). This family contains several actinomycete proteins of unknown function.. 
+PF05259 Herpesvirus glycoprotein L<br>Pfam-B_7535 (release 7.7). This family consists of several herpesvirus glycoprotein L or UL1 proteins. Glycoprotein L is known to form a complex with glycoprotein H but the function of this complex is poorly understood  .. 
+PF05261 TraM protein, DNA-binding<br>Pfam-B_7584 (release 7.7). The TraM protein is an essential part of the DNA transfer machinery of the conjugative resistance plasmid R1 (IncFII). On the basis of mutational  analyses, it was shown that the essential transfer protein TraM has at least two functions. First, a functional TraM protein was found to be  required for normal levels of transfer gene expression. Second, experimental evidence was obtained that TraM stimulates efficient site-specific single-stranded DNA cleavage at the oriT, in vivo. Furthermore, a specific interaction of the cytoplasmic TraM protein with the membrane protein TraD was demonstrated, suggesting that the TraM  protein creates a physical link between the relaxosomal nucleoprotein  complex and the membrane-bound DNA transfer apparatus  .. 
+PF05262 Borrelia P83/100 protein<br>Pfam-B_6712 (release 7.7). This family consists of several Borrelia P83/P100 antigen proteins.. 
+PF05263 Protein of unknown function (DUF722)<br>Pfam-B_6789 (release 7.7). This family contains several bacteriophage proteins of unknown function.. 
+PF05264 Choristoneura fumiferana antifreeze protein (CfAFP)<br>Pfam-B_6800 (release 7.7). This family consists of several antifreeze proteins from the insect Choristoneura fumiferana (Spruce budworm). Antifreeze proteins (AFPs) and  antifreeze glycoproteins (AFGPs) are present in many organisms that must survive sub-zero temperatures. These proteins bind to seed ice crystals and inhibit their growth through an adsorption-inhibition mechanism  .. 
+PF05265 Protein of unknown function (DUF723)<br>Pfam-B_6852 (release 7.7). This family contains several uncharacterised proteins from Neisseria meningitidis. These proteins may have a role in DNA-binding.. 
+PF05266 Protein of unknown function (DUF724)<br>Pfam-B_6894 (release 7.7). This family contains several uncharacterised proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.. 
+PF05267 Protein of unknown function (DUF725)<br>Pfam-B_6905 (release 7.7). This family contains several Drosophila proteins of unknown function.. 
+PF05268 Phage tail fibre adhesin Gp38<br>Pfam-B_7415 (release 7.7). This family contains several Gp38 proteins from T-even-like phages. Gp38,  together with a second phage protein, gp57, catalyses the organisation of  gp37 but is absent from the phage particle. Gp37 is responsible for  receptor recognition  .. 
+PF05269 Bacteriophage CII protein<br>Pfam-B_7453 (release 7.7). This family consists of several phage CII regulatory proteins. CII plays a key role in the lysis-lysogeny decision in bacteriophage lambda and related phages  .. 
+PF05270 Alpha-L-arabinofuranosidase B (ABFB)<br>Pfam-B_7464 (release 7.7). This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is  formed by 1,5-a- linked l-arabinose residues that can be branched via  1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses  1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and  polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains  .. 
+PF05271 Tobravirus 2B protein<br>Pfam-B_7517 (release 7.7). This family consists of several tobravirus 2B proteins. It is known that the 2B protein is required for transmission by both Paratrichodorus  pachydermus and P. anemones nematodes  .. 
+PF05272 Virulence-associated protein E<br>Pfam-B_6573 (release 7.7). This family contains several bacterial virulence-associated protein E like proteins. These proteins contain a P-loop motif.. 
+PF05273 Poxvirus RNA polymerase 22 kDa subunit<br>Pfam-B_6584 (release 7.7). This family consists of several poxvirus DNA-dependent RNA polymerase 22 kDa subunits.. 
+PF05274 Occlusion-derived virus envelope protein E25<br>Pfam-B_6633 (release 7.7). This family consists of several nucleopolyhedrovirus occlusion-derived virus envelope E25 proteins.. 
+PF05275 Copper resistance protein B precursor (CopB)<br>Pfam-B_6721 (release 7.7). This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every  organism. CopB serves to extrude copper when it approaches toxic levels  .. 
+PF05276 SH3 domain-binding protein 5 (SH3BP5)<br>Pfam-B_6742 (release 7.7). This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk).  Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule  .. 
+PF05277 Protein of unknown function (DUF726)<br>Pfam-B_6757 (release 7.7). This family consists of several uncharacterised eukaryotic proteins.. 
+PF05278 Arabidopsis phospholipase-like protein (PEARLI 4)<br>Pfam-B_6763 (release 7.7). This family contains several phospholipase-like proteins from Arabidopsis thaliana which are homologous to PEARLI 4.. 
+PF05279 Aspartyl beta-hydroxylase N-terminal region<br>Pfam-B_6767 (release 7.7). This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin  . Aspartyl beta-hydroxylase catalyses the post-translational hydroxylation of aspartic acid or asparagine residues contained within epidermal growth factor (EGF) domains of proteins  .. 
+PF05280 Flagellar transcriptional activator (FlhC)<br>Pfam-B_6773 (release 7.7). This family consists of several bacterial flagellar transcriptional activator (FlhC) proteins. FlhC combines with FlhD to form a regulatory complex in E. coli, this complex has been shown to be a global regulator  involved in many cellular processes as well as a flagellar transcriptional activator  .. 
+PF05281 Neuroendocrine protein 7B2 precursor (Secretogranin V)<br>Pfam-B_6776 (release 7.7). The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia  .. 
+PF05282 AAR2 protein<br>Pfam-B_6782 (release 7.7). This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth  .. 
+PF05283 Multi-glycosylated core protein 24 (MGC-24)<br>Pfam-B_6825 (release 7.7). This family consists of several MGC-24 (or Cd164 antigen) proteins from  eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many  normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing  .. 
+PF05284 Protein of unknown function (DUF736)<br>Pfam-B_7619 (release 7.7). This family consists of several uncharacterised bacterial proteins of unknown function.. 
+PF05285 SDA1<br>Pfam-B_6906 (release 7.7). This family consists of several SDA1 protein homologues. SDA1 is a Saccharomyces cerevisiae protein which is involved in the control of the actin cytoskeleton. The protein is essential for cell viability and is localised in the nucleus  .. 
+PF05287 PMG protein<br>Pfam-B_7710 (release 7.7). This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages  .. 
+PF05288 Poxvirus A3L Protein<br>Pfam-B_7718 (release 7.7). This family consists of several poxvirus A3L or A2_5L proteins.. 
+PF05289 Borrelia hemolysin accessory protein<br>Pfam-B_7729 (release 7.7). This family consists of several borrelia hemolysin accessory proteins (BLYB). BLYB was thought to be an accessory protein, which was proposed to comprise a hemolysis system but it is now thought that BlyA and BlyB function instead as a prophage-encoded holin or holin-like system  .. 
+PF05290 Baculovirus immediate-early protein (IE-0)<br>Pfam-B_7745 (release 7.7). The Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV) ie-1 gene product (IE-1) is thought to play a central role in stimulating early viral transcription. IE-1 has been demonstrated to activate several early viral gene promoters and to negatively regulate the promoters of two other AcMNPV regulatory genes, ie-0 and ie-2. It is thought that that IE-1 negatively regulates the expression of certain genes by binding directly, or as part of a complex, to promoter regions containing a specific IE-1-binding motif (5'-ACBYGTAA-3') near their mRNA start sites  .. 
+PF05291 Bystin<br>Pfam-B_7767 (release 7.7). Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy  . This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localised in the nucleus  . It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesise 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits  .. 
+PF05292 Malonyl-CoA decarboxylase (MCD)<br>Pfam-B_7770 (release 7.7). This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidised. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK)  .. 
+PF05293 African swine fever virus (ASFV) L11L protein<br>Pfam-B_7869 (release 7.7). L11L is an integral membrane protein of the African swine fever virus (ASFV) which is expressed late in the virus replication cycle. The protein is thought to be non-essential for growth in vitro and for virus virulence in domestic swine  .. 
+PF05294 toxin_5; <br>Scorpion short toxin. Pfam-B_7892 (release 7.7). This family contains various secreted scorpion short toxins and seems to be unrelated to Pfam:PF00451.. 
+PF05295 Luciferase; <br>Luciferase/LBP N-terminal domain. Pfam-B_7906 (release 7.7). This family consists of a presumed N-terminal domain that is conserved between dinoflagellate luciferase and luciferin binding proteins. Luciferase is involved in catalysing the light emitting reaction in bioluminescence and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme and therefore switching off the bioluminescence function. The expression of these two proteins is controlled by a circadian clock at the translational level, with synthesis and degradation occurring on a daily basis  . However This domain is not the catalytic part of the protein.  It has been suggested that this region may mediate an interaction between LBP and Luciferase or their association with the vacuolar membrane  .. 
+PF05296 Mammalian taste receptor protein (TAS2R)<br>Pfam-B_1498 (release 7.7). This family consists of several forms of mammalian taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia and are organised in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans  .. 
+PF05297 Herpesvirus latent membrane protein 1 (LMP1)<br>Pfam-B_5174 (release 7.7). This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N-terminus and a long cytoplasmic carboxy tail of 200 amino acids. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high  lymphoma rates in immunosuppressed monkeys  . 
+PF05298 Bombinin<br>Pfam-B_5347 (release 7.7). This family consists of Bombinin and Maximin proteins from Bombina maxima (Chinese red belly toad). Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumour cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 have been found to be toxic to mice. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides  .. 
+PF05299 M61 glycyl aminopeptidase<br>Glycyl aminopeptidase is an unusual peptidase in that it has a preference for substrates with an N-terminal glycine or alanine. These proteins are found in Bacteria and in Archaea.. 
+PF05300 Protein of unknown function (DUF737)<br>Pfam-B_6933 (release 7.7). This family consists of several uncharacterised mammalian proteins of unknown function.. 
+PF05301 DUF738; <br>Touch receptor neuron protein Mec-17. Moxon SJ, Pollington JE. Pfam-B_6943 (release 7.7). Mec-17 is the protein product of one of the 18 genes required for the development and function of the touch receptor neuron for gentle touch. Mec-17 is specifically required for maintaining the differentiation of the touch receptor  . This family is conserved to higher eukaryotes.. 
+PF05302 Protein of unknown function (DUF720)<br>Pfam-B_6980 (release 7.7). This family consists of several uncharacterised Chlamydia proteins of unknown function.. 
+PF05303 Protein of unknown function (DUF727)<br>Pfam-B_7004 (release 7.7). This family consists of several uncharacterised eukaryotic proteins of unknown function.. 
+PF05304 Protein of unknown function (DUF728)<br>Pfam-B_7223 (release 7.7). This family consists of several uncharacterised tobravirus proteins of unknown function.. 
+PF05305 Protein of unknown function (DUF732)<br>Pfam-B_7356 (release 7.7). This family consists of several uncharacterised Mycobacterium tuberculosis and leprae proteins of unknown function.. 
+PF05306 Protein of unknown function (DUF733)<br>Pfam-B_7392 (release 7.7). This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.. 
+PF05307 Bundlin<br>Pfam-B_6974 (release 7.7). This family consists of several bundlin proteins from E. coli. Bundlin is a type IV pilin protein that is the only known structural component of  enteropathogenic Escherichia coli bundle-forming pili (BFP). BFP play a role in virulence, antigenicity, autoaggregation, and localised adherence  to epithelial cells  .. 
+PF05308 DUF729;<br>Mitochondrial fission regulator. Moxon SJ, Eberhardt R. Pfam-B_6919 (release 7.7). In eukaryotes, this family of proteins induces mitochondrial fission [1,2].. 
+PF05309 TraE protein<br>Pfam-B_7677 (release 7.7). This family consists of several bacterial sex pilus assembly and synthesis proteins (TraE). Conjugal transfer of plasmids from donor to recipient  cells is a complex process in which a cell-to-cell contact plays a key role. Many genes encoded by self-transmissible plasmids are required for various processes of conjugation, including pilus formation, stabilisation of mating pairs, conjugative DNA metabolism, surface exclusion and regulation of transfer gene expression  . The exact function of the TraE protein is unknown.. 
+PF05310 Tenuivirus_NS3; <br>Tenuivirus movement protein. Pfam-B_7740 (release 7.7). This family of ssRNA negative-strand crop plant tenuivirus proteins appears to combine PV2  , NS2  , NS3, and PV3 proteins. Plant viruses encode specific proteins known as movement proteins (MPs) to control their spread through plasmodesmata (PD) in walls between cells as well as from leaf to leaf via vascular-dependent transport.  During this movement process, the virally encoded MPs interact with viral genomes for transport from the viral replication sites to the PDs in the walls of infected cells along the cytoskeleton and/or endoplasmic reticulum (ER) network. The virus is then thought to move through the PDs in the form of MP-associated ribonucleoprotein complexes or as virions  . The NS3 protein appears to function as an RNA silencing suppressor  .. 
+PF05311 Baculovirus 33KDa late protein (PP31)<br>Pfam-B_7777 (release 7.7). Autographa californica nuclear polyhedrosis virus (AcMNPV) pp31 is a  nuclear phosphoprotein that accumulates in the virogenic stroma, which is the viral replication centre in the infected-cell nucleus, binds to DNA, and serves as a late expression factor  .. 
+PF05313 Poxvirus P21 membrane protein<br>Pfam-B_7803 (release 7.7). The P21 membrane protein of vaccinia virus, encoded by the A17L (or A18L) gene, has been reported to localise on the inner of the two membranes of the intracellular mature virus (IMV). It has also been shown that P21 acts as a membrane anchor for the externally located fusion protein P14 (A27L gene)  . . 
+PF05314 Baculovirus occlusion-derived virus envelope protein EC27<br>Pfam-B_7811 (release 7.7). This family consists of several baculovirus occlusion-derived virus envelope proteins (EC27 or E27). The ODV-E27 protein has distinct functional characteristics compared to cellular and viral cyclins. Depending on the cdk protein, and perhaps other viral or cellular proteins yet to be described, the kinase-EC27 complex may have either cyclin B- or  D-like activity  .. 
+PF05315 ICEA Protein<br>Pfam-B_2792 (release 7.7). This family consists of several ICEA proteins from Helicobacter pylori. Helicobacter pylori infection causes gastritis and peptic ulcer disease, and is classified as a definite carcinogen of gastric cancer. ICEA1 is  speculated to be associated with peptic ulcer disease  .. 
+PF05316 Yeast_VAR1; <br>Mitochondrial ribosomal protein (VAR1). Pfam-B_7802 (release 7.7). This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal  proteins are encoded in the nucleus  . VAR1 along with 15S rRNA are  necessary for the formation of mature 37S subunits  .. 
+PF05317 Thermopsin<br>Pfam-B_7819 (release 7.7). This family consists of several thermopsin proteins from archaebacteria. Thermopsin is a thermostable acid protease which is capable of hydrolysing the following bonds: Leu-Val, Leu-Tyr, Phe-Phe, Phe-Tyr, and Tyr-Thr. The specificity of thermopsin is therefore similar to that of pepsin, that is, it prefers large hydrophobic residues at both sides of the scissile bond  .. 
+PF05318 Tombusvirus movement protein<br>Pfam-B_4393 (release 7.7). This family consists of several Tombusvirus movement proteins. These proteins allow the virus to move from cell-to-cell and allow host-specific systemic spread  . . 
+PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit<br>Pfam-B_6945 (release 7.7). This family contains several DNA-directed RNA polymerase 19 kDa polypeptides. The Poxvirus DNA-directed RNA polymerase (EC: 2.7.7.6)  catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.. 
+PF05321 Haemolysin expression modulating protein<br>Pfam-B_7025 (release 7.7). This family consists of haemolysin expression modulating protein (HHA) homologues. YmoA and Hha are highly similar bacterial proteins  downregulating gene expression in Yersinia enterocolitica and Escherichia  coli, respectively.. 
+PF05322 NINE; <br>Pfam-B_7029 (release 7.7). This family consists of NINE proteins from several bacteriophages and from E. coli.. 
+PF05323 Poxvirus A21 Protein<br>Pfam-B_7034 (release 7.7). This family consists of several poxvirus A21 proteins.. 
+PF05324 Sperm antigen HE2<br>Pfam-B_7044 (release 7.7). This family consists of several variants of the human and chimpanzee sperm  antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a  family of androgen-dependent, epididymis-specific secretory proteins.The  EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages.  The translated putative protein variants differ significantly from each other. Some of these putative proteins have  similarity to beta-defensins, a family of antimicrobial peptides  .. 
+PF05325 Protein of unknown function (DUF730)<br>Pfam-B_7197 (release 7.7). This family consists of several uncharacterised Arabidopsis thaliana proteins of unknown function.. 
+PF05326 Seminal vesicle autoantigen (SVA)<br>Pfam-B_7065 (release 7.7). This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory glycoprotein suppresses the motility of spermatozoa by interacting with phospholipid. PIP, has several known functions. In saliva, this protein plays a role in host defence by binding to microorganisms such as Streptococcus. PIP is an aspartyl proteinase and it acts as a factor capable of suppressing T-cell apoptosis through its interaction with CD4  .. 
+PF05327 RNA polymerase I specific transcription initiation factor RRN3<br>Pfam-B_7041 (release 7.7). This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required  for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae  .. 
+PF05328 CybS<br>Pfam-B_7102 (release 7.7). This family consists of several eukaryotic succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) proteins. SDHD encodes the small subunit (cybS) of cytochrome b in succinate-ubiquinone oxidoreductase (mitochondrial complex II).  Mitochondrial complex II is involved in the Krebs cycle and in the aerobic electron transport chain. It contains four proteins. The catalytic core consists of a flavoprotein and an iron-sulfur protein; these proteins are anchored to the mitochondrial inner membrane by the large subunit of cytochrome b (cybL) and cybS, which together comprise the heme-protein cytochrome b. Mutations in the SDHD gene can lead to hereditary paraganglioma, characterised by the development of benign, vascularised tumours in the head and neck  .. 
+PF05331 Protein of unknown function (DUF742)<br>Pfam-B_3675 (release 7.7). This family consists of several uncharacterised Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.. 
+PF05332 Protein of unknown function (DUF743)<br>Pfam-B_4046 (release 7.7). This family consists of several uncharacterised Calicivirus proteins of unknown function.. 
+PF05334 Protein of unknown function (DUF719)<br>Pfam-B_7667 (release 7.7). This family consists of several eukaryotic proteins of unknown function.. 
+PF05335 Protein of unknown function (DUF745)<br>Pfam-B_5169 (release 7.7). This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.. 
+PF05336 Domain of unknown function (DUF718)<br>Pfam-B_7227 (release 7.7). This family consists of several uncharacterised bacterial proteins of unknown function.. 
+PF05337 Macrophage colony stimulating factor-1 (CSF-1)<br>Pfam-B_7649 (release 7.7). Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth  factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic  lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility   and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption  .. 
+PF05338 Protein of unknown function (DUF717)<br>Pfam-B_7144 (release 7.7). This family consists of several herpesvirus proteins of unknown function.. 
+PF05339 Protein of unknown function (DUF739)<br>Pfam-B_7696 (release 7.7). This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.. 
+PF05340 Protein of unknown function (DUF740)<br>Pfam-B_7873 (release 7.7). This family consists of several uncharacterised plant proteins of unknown function.. 
+PF05341 Protein of unknown function (DUF708)<br>Pfam-B_7259 (release 7.7). This family consists of several uncharacterised nucleopolyhedrovirus proteins of unknown function.. 
+PF05342 Peptidase_M26; <br>M26 IgA1-specific Metallo-endopeptidase N-terminal region. These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with Pfam:PF00746, they may be attached to the cell wall.. 
+PF05343 M42 glutamyl aminopeptidase<br>These peptidases are found in Archaea and Bacteria. The example in Lactococcus lactis, PepA, aids growth on milk  .     Pyrococcus horikoshii contain a thermostable de-blocking  aminopeptidase member of this family used commercially for N-terminal protein sequencing  .. 
+PF05344 Domain of Unknown Function (DUF746)<br>Yeats C, Eberhardt R. This is a short conserved region found in some transposons. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF05345 Putative Ig domain<br>This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to  (Pfam:PF02494) and (Pfam:PF00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (Pfam:PF02639) and  (Pfam:PF02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei ( ).. 
+PF05346 Eukaryotic membrane protein family<br>Pfam-B_13582 (release 7.8). This family is a family of eukaryotic membrane proteins.  It was previously annotated as including a putative receptor for human cytomegalovirus gH   but this has has since been disputed  . Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.. 
+PF05347 Complex 1 protein (LYR family)<br>Pfam-B_15215 (release 7.8). Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex.  In Saccharomyces cerevisiae, the Isd11 protein (Swiss:Q6Q560) has been shown to play a role in Fe/S cluster biogenesis in mitochondria   . We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.. 
+PF05348 Proteasome maturation factor UMP1<br>Pfam-B_18845 (release 7.8). UMP1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. UMP1 is required for the correct assembly and enzymatic activation of the proteasome. UMP1 seems to be degraded by the proteasome upon its formation. 
+PF05349 GATA-type transcription activator, N-terminal <br>
+PF05350 Glycogen synthase kinase-3 binding<br>Pfam-B_18811 (release 7.8). Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four  serine residues on glycogen synthase (GS), in the sequence  SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the first  serine in the sequence motif SxxxS(P) (where S(p) represents a  phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of  beta-catenin by GSK-3  . . 
+PF05351 GMP-PDE, delta subunit<br>Pfam-B_13828 (release 7.8). GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35).  The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues.  PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport  .. 
+PF05352 Phage Connector (GP10)<br>Pfam-B_13828 (release 7.8). The head-tail connector of bacteriophage 29 is composed of 12  36  kDa subunits with 12 fold symmetry. It is the central component  of a rotary motor that packages the genomic dsDNA into pre-formed  proheads. This motor consists of the head-tail connector, surrounded  by a 29-encoded, 174-base, RNA and a viral ATPase protein [1,2].. 
+PF05353 Delta Atracotoxin<br>Pfam-B_30981 (release 7.8). Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing he inactivation of voltage-gated sodium channels  .  The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix.  The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides  .. 
+PF05354 Phage Head-Tail Attachment<br>Pfam-B_59968 (release 7.8). The phage head-tail attachment protein is required for the joining of phage heads and tails at the last step of morphogenesis  .. 
+PF05355 Apolipoprotein C-II<br>Pfam-B_6456 (release 7.8). Apolipoprotein C-II (ApoC-II) is the major activator of lipoprotein lipase, a key enzyme in the regulation of triglyceride levels in human serum  .. 
+PF05356 Phage Coat protein B <br>Pfam-B_51500 (release 7.8). The major coat protein in the capsid of filamentous bacteriophage forms a helical assembly of about 7000 identical protomers, with each protomer comprised of 46 amino acid, after the cleavage of the signal peptide.  Each protomer forms a slightly curved helix that combine to form a tubular structure that encapsulates the viral DNA  .. 
+PF05357 Phage Coat Protein A<br>Pfam-B_7225 (release 7.8). Infection of Escherichia coli by filamentous bacteriophages is mediated  by the minor phage coat protein A and involves two distinct cellular receptors, the F' pilus and the periplasmic protein TolA.  These two receptors are contacted in a sequential manner, such that  binding of TolA by the extreme N-terminal domain is conditional on a  primary interaction of the second coat protein A domain with the F'  pilus  .. 
+PF05358 DicB protein<br>DicB is part of the dic operon, which resides on cryptic prophage Kim. Under normal conditions, expression of dicB is actively repressed. When expression is induced, however, cell division rapidly ceases, and this division block is dependent on MinC with which it interacts  .. 
+PF05359 Domain of Unknown Function (DUF748)<br>
+PF05360 yiaA/B two helix domain<br>This domain consists of two transmembrane helices and a conserved linking section.. 
+PF05361 PKC-activated protein phosphatase-1 inhibitor<br>Pfam-B_69711 (release 7.8). Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction  .. 
+PF05362 Lon protease (S16) C-terminal proteolytic domain<br>The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.. 
+PF05363 Herpesvirus US12 family<br>Pfam-B_62991 (release 7.8). US12 a key factor in the evasion of cellular immune response against HSV-infected cells. Specific inhibition of the transporter associated with antigen processing (TAP) by US12 prevents peptide transport into the endoplasmic reticulum and subsequent loading of major histocompatibility complex (MHC) class I molecules  . US12 is comprised of three helices and is associated with cellular membranes  .. 
+PF05364 SecIII_SopE; <br>Salmonella type III secretion SopE effector N-terminus. Pfam-B_18665 (release 7.8). Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, one of these toxins, can activate Cdc42 in a Dbl-like fashion via its C-terminal GEP domain Pfam:PF07487  . This family represents the N-terminal region of SopE. The function of this domain is unknown.. 
+PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like<br>Pfam-B_18986 (release 7.8). The UQCRX/QCR9 protein is the 9/10 subunit of complex III, encoding a protein of about 7-kDa. Deletion of QCR9 results in the inability of cells  to grow on grow on-fermentable carbon source n yeast  .. 
+PF05366 Sarcolipin<br>Pfam-B_33603 (release 7.8). Sarcolipin is a 31 amino acid integral membrane  protein that regulates Ca-ATPase activity in skeletal  muscle  .. 
+PF05367 Phage endonuclease I<br>Pfam-B_22152 (release 7.8). The bacteriophage endonuclease I is a nuclease that is selective  for the structure of the four-way Holliday DNA  junction  .. 
+PF05368 NmrA-like family<br>Pfam-B_25329 (release 7.8). NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi  .  This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.. 
+PF05369 Monomethylamine methyltransferase MtmB<br>Pfam-B_58618 (release 7.8). Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG [1,2]. The structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold  .. 
+PF05370 Domain of unknown function (DUF749)<br>Pfam-B_54547 (release 7.8). Archaeal domain of unknown function.  This domain has been solved as part of a structural genomics project and comprises of segregated  helical and anti-parallel beta sheet regions.. 
+PF05371 Phage major coat protein, Gp8<br>Pfam-B_31655 (release 7.8). Class I phage major coat protein Gp8 or B.  The coat protein  is largely alpha-helix with a slight curve  .   . 
+PF05372 Delta lysin family<br>Pfam-B_45919 (release 7.8). Delta-lysin is a 26 amino acid, hemolytic peptide toxin secreted  by Staphylococcus aureus. It is thought that delta-toxin  forms an amphipathic helix upon binding to lipid bilayers  . The precise mode of action of delta-lysis is unclear.. 
+PF05373 L-proline 3-hydroxylase, C-terminal<br>Pfam-B_32425 (release 7.8). Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes.  Proline 3-hydroxylase  hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure contains conserved motifs present in other 2-OG oxygenases including a  jelly roll strand core and residues binding iron and 2-oxoglutarate,  consistent with divergent evolution within the extended family.  The structure differs significantly from many other 2-OG oxygenases in possessing a discrete C-terminal helical domain.. 
+PF05374 Mu-Conotoxin<br>Pfam-B_34209 (release 7.8). Mu-conotoxins are peptide inhibitors of voltage-sensitive sodium channels  .. 
+PF05375 Pacifastin inhibitor (LCMII)<br>Pfam-B_35181 (release 7.8). Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors [1,2]. . 
+PF05377 Flagella accessory protein C (FlaC)<br>Although archaeal flagella appear superficially similar to those of bacteria, they are quite distinct . In several archaea, the flagellin genes are followed immediately by the flagellar accessory genes flaCDEFGHIJ.  The gene products may have a role in translocation, secretion, or assembly of the flagellum. FlaC is a protein whose exact role is unknown but it has been shown to be membrane-associated (by immuno-blotting fractionated cells)  .. 
+PF05378 Hydantoinase/oxoprolinase N-terminal region<br>This family is found at the N-terminus of the Pfam:PF01968 family.. 
+PF05379 Carlavirus endopeptidase <br>A peptidase involved in auto-proteolysis of a polyprotein from the plant pathogen blueberry scorch carlavirus (BBScV) . Corresponds to Merops family C23. . 
+PF05380 Pao retrotransposon peptidase <br>Corresponds to Merops family A17. These proteins are homologous to aspartic proteinases encoded by retroposons and retroviruses.. 
+PF05381 Tymovirus endopeptidase<br>Corresponds to Merops family C21. The best-studied plant alpha-like virus proteolytic enzyme is the proteinase of turnip yellow mosaic virus (TYMV). The TYMV replicase protein undergoes auto-cleavage to yield two products.  The auto-peptidase activity has been mapped to the central part of this polyprotein.. 
+PF05382 Bacteriophage peptidoglycan hydrolase <br>Pfam-B_6845 (Pfam7.8). At least one of the members of this family, the Pal protein from the pneumococcal bacteriophage Dp-1 Swiss:O03979 has been shown to be a N-acetylmuramoyl-L-alanine amidase  . According to the known modular structure of this and other peptidoglycan hydrolases from the pneumococcal system, the active site should reside at the N-terminal domain whereas the C-terminal domain binds to the choline residues of the cell wall teichoic acids [2,3].  This family appears to be related to Pfam:PF00877.. 
+PF05383 La domain<br>This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins  . The function of this region is uncertain.. 
+PF05384 Sensor protein DegS<br>This is small family of Bacillus DegS proteins.  The DegS-DegU two-component regulatory system of Bacillus subtilis controls various processes that characterise the transition from the exponential to the stationary growth phase, including the induction of extracellular degradative enzymes, expression of late competence genes and down-regulation of the sigma D regulon  . The family also contains one sequence Swiss:Q8R9D3 from Thermoanaerobacter tengcongensis which are described as sensory transduction histidine kinases.. 
+PF05385 M_adenovirusE4; <br>Mastadenovirus early E4 13 kDa protein. This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9  .. 
+PF05386 TEP1 N-terminal domain<br>This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain.  However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.. 
+PF05387 Chorion family 3<br>This family consists of several Drosophila chorion proteins S36 and S38. The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary  .. 
+PF05388 Carboxypeptidase Y pro-peptide<br>This family is found at the N terminus of several carboxypeptidase Y proteins and contains a signal peptide and pro-peptide regions [1,2].. 
+PF05389 Negative regulator of genetic competence (MecA)<br>This family contains several bacterial MecA proteins. The development of competence in Bacillus subtilis is regulated by growth conditions and several regulatory genes. In complex media competence development is poor, and there is little or no expression of late competence genes. Mec  mutations permit competence development and late competence gene expression in complex media, bypassing the requirements for many of the competence regulatory genes. The mecA gene product acts negatively in the development of competence. Null mutations in mecA allow expression of a late competence gene comG, under conditions where it is not normally expressed, including in complex media and in cells mutant for several competence regulatory genes. Overexpression of MecA inhibits comG transcription [1,2,3].. 
+PF05390 Yeast cell wall synthesis protein KRE9/KNH1<br>This family contains several KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, which are required for beta -1,6-glucan synthesis in yeast  .. 
+PF05391 Lsm interaction motif<br>This short motif is found at the C-terminus of Prp24 proteins and probably interacts with the Lsm proteins to promote U4/U6 formation  .. 
+PF05392 Cytochrome C oxidase chain VIIB<br>
+PF05393 Human adenovirus early E3A glycoprotein<br>This family consists of several early glycoproteins from human adenoviruses.. 
+PF05394 Pseu_avirulence;<br>This family consists of several avirulence proteins from Pseudomonas syringae and Xanthomonas campestris.. 
+PF05395 Protein phosphatase inhibitor 1/DARPP-32<br>This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1  . It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1  . DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive  . A mutant form of DARPP-32 has been linked with gastric cancers  .. 
+PF05396 Phage T7 capsid assembly protein<br>
+PF05397 GAL11;<br>Mediator complex subunit 15. GAL11 or MED15 is one of the up to 32 or subunits of the Mediator complex which is found from fungi to humans  . The Mediator complex interacts with RNA polymerase II and other general transcription factors to form the RNA polymerase II holoenzyme  , thereby affecting transcription through targetting of activators and repressors  . This family is found in fungi and the small metazoan starlet anemone.. 
+PF05398 PufQ cytochrome subunit<br>This family consists of bacterial PufQ proteins. PufQ id required for bacteriochlorophyll biosynthesis serving a regulatory function in the formation of photosynthetic complexes  .. 
+PF05399 Ectropic viral integration site 2A protein (EVI2A)<br>This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumours [1,2].. 
+PF05400 Flagellar protein FliT<br>This family contains several bacterial flagellar FliT proteins. The  flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium  .  . 
+PF05401 Nodulation protein S (NodS)<br>This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors  .. 
+PF05402 Coenzyme PQQ synthesis protein D (PqqD)<br>This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis [1,2].. 
+PF05403 Plasmodium histidine-rich protein (HRPII/III)<br>This family consists of several histidine-rich protein II and III sequence from Plasmodium falciparum [1,2].. 
+PF05404 Translocon-associated protein, delta subunit precursor (TRAP-delta)<br>Pfam-B_7178 (release 7.7). This family consists of several eukaryotic translocon-associated protein, delta subunit precursors (TRAP-delta or SSR-delta). The exact function of this protein is unknown [1,2].. 
+PF05405 Mitochondrial ATP synthase B chain precursor (ATP-synt_B)<br>Pfam-B_7506 (release 7.7). The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport. It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L)  .. 
+PF05406 WGR domain<br>This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Swiss:Q9JN21 and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain.. 
+PF05407 Rubella virus endopeptidase<br>Corresponds to Merops family C27. Required for processing of the rubella virus replication protein.. 
+PF05408 Foot-and-mouth virus L-proteinase<br>Corresponds to Merops family C28. Protein fold of the peptidase unit for members of this family resembles that of papain. The leader proteinase of foot and mouth disease virus (FMDV) cleaves itself from the growing polyprotein and also cleaves the host translation initiation factor 4GI (eIF4G), thus inhibiting 5'-cap dependent translation.. 
+PF05409 Coronavirus  endopeptidase C30<br>Corresponds to Merops family C30. These peptidases are involved in  viral polyprotein processing in replication.. 
+PF05410 Porcine arterivirus-type cysteine proteinase alpha<br>Corresponds to Merops family C31. These peptidases are involved in viral polyprotein processing in replication.. 
+PF05411 Equine arteritis virus putative proteinase<br>These proteins are characterised by a region that has been proposed to have peptidase activity involved in viral polyprotein processing in replication.. 
+PF05412 Equine arterivirus Nsp2-type cysteine proteinase<br>Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.. 
+PF05413 Putative closterovirus papain-like endopeptidase<br>Corresponds to Merops family C34. Putative closterovirus papain-like  endopeptidase from the apple chlorotic  leaf spot closterovirus.. 
+PF05414 Peptidase_C35; <br>Viral domain of unknown function (DUF1717). This domain is found in viral proteins of unknown function.. 
+PF05415 Beet necrotic yellow vein furovirus-type papain-like endopeptidase<br>Corresponds to Merops family C36. This protease involved in processing the viral polyprotein.. 
+PF05416 Southampton virus-type processing peptidase<br>Corresponds to Merops family C37. Norwalk-like viruses (NLVs), including the Southampton virus, cause acute non-bacterial gastroenteritis in humans. The NLV genome encodes three open reading frames (ORFs). ORF1 encodes a polyprotein, which is processed by the viral protease into six proteins.. 
+PF05417 Hepatitis E cysteine protease<br>Corresponds to MEROPs family C41. This papain-like protease cleaves the viral polyprotein encoded by ORF1 of the hepatitis E virus (HEV).. 
+PF05418 Apovitellenin I (Apo-VLDL-II)<br>This family consists of several avian apovitellenin I sequences. As part of the avian reproductive effort, large quantities of triglyceride-rich very-low-density lipoprotein (VLDL) particles are transported by receptor-mediated endocytosis into the female germ cells. Although the oocytes are surrounded by a layer of granulosa cells harbouring high levels of active lipoprotein lipase, non-lipolysed VLDL is transported into the yolk. This is because VLDL particles from laying chickens are protected from lipolysis by apolipoprotein (apo)-VLDL-II, a potent dimeric lipoprotein lipase inhibitor  . Apo-VLDL-II is produced in the liver and secreted into the blood stream when induced by estrogen production in female birds.. 
+PF05419 GUN4-like <br>In Arabidopsis, GUN4 is required for the functioning of the plastid mediated repression of nuclear transcription that is involved in controlling the levels of magnesium- protoporphyrin IX.  GUN4 binds the product and substrate of Mg-chelatase, an enzyme that produces Mg-Proto, and activates  Mg-chelatase. GUN4 is thought to participates in plastid-to-nucleus  signaling by regulating magnesium-protoporphyrin IX synthesis or  trafficking.. 
+PF05420 BCSC_N; <br>Cellulose synthase operon protein C C-terminus (BCSC_C). Pfam-B_10335 (release 8.0). This family contains the C-terminal regions of several bacterial cellulose synthase operon C (BCSC) proteins. BCSC is involved in cellulose synthesis although the exact function of this protein is unknown  .. 
+PF05421 Protein of unknown function (DUF751)<br>Pfam-B_10849 (release 8.0). This family contains several plant, cyanobacterial and algal proteins of unknown function. The family is exclusively found in phototrophic organisms and may therefore play a role in photosynthesis (personal obs:Moxon SJ).. 
+PF05422 Stress-activated map kinase interacting protein 1 (SIN1)<br>Pfam-B_10677 (release 8.0). This family consists of several stress-activated map kinase interacting protein 1 (MAPKAP1 OR SIN1) sequences. The fission yeast Sty1/Spc1 mitogen-activated protein (MAP) kinase is a member of the eukaryotic stress-activated MAP kinase (SAPK) family. Sin1 interacts with Sty1/Spc1. Cells lacking Sin1 display many, but not all, of the phenotypes of cells lacking the Sty1/Spc1 MAP kinase including sterility, multiple stress sensitivity and a cell-cycle delay. Sin1 is phosphorylated after stress but this is not Sty1/Spc1-dependent  . . 
+PF05423 Mycobacterium membrane protein<br>Pfam-B_10885 (release 8.0). This family contains several membrane proteins from Mycobacterium species.. 
+PF05424 Duffy binding domain<br>Pfam-B_11112 (release 8.0). This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa  . This family is closely associated on PfEMP1 proteins with PFEMP, Pfam:PF03011.. 
+PF05425 Copper resistance protein D<br>Pfam-B_19002 (release 8.0). Copper sequestering activity displayed by some bacteria is determined by copper-binding protein products of the copper resistance operon (cop). CopD, together with CopC, perform copper uptake into the cytoplasm  .. 
+PF05426 Alginate lyase<br>Moxon SJ, Mistry J, Murzin A. Pfam-B_11800 (release 8.0). This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyse the depolymerisation of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end  .  This family adopts an all alpha fold  .. 
+PF05427 Acidic fibroblast growth factor binding (FIBP) <br>Pfam-B_19083 (release 8.0). Acidic fibroblast growth factor (aFGF) intracellular binding  protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF  .. 
+PF05428 Corticotropin-releasing factor binding protein (CRF-BP)<br>Pfam-B_11928 (release 8.0). This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development  .. 
+PF05430 DUF752;<br>S-adenosyl-L-methionine-dependent methyltransferase. Moxon SJ, Eberhardt R. Pfam-B_12088 (release 8.0). This family is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. It is often found in association with Pfam:PF01266, where it is responsible for catalysing the transfer of a methyl group from S-adenosyl-L-methionine to 5-aminomethyl-2-thiouridine to form 5-methylaminomethyl-2-thiouridine [1,2].. 
+PF05431 Toxin_P42; <br>Insecticidal Crystal Toxin, P42 . Pfam-B_19338 (release 8.0). Family of Bacillus insecticidal crystal toxins.  Strains of Bacillus that have this insecticidal activity use a binary toxin comprised of two proteins, P51 and P42 (this family).  Members of this family are highly conserved  between strains of different serotypes and phage groups  .. 
+PF05432 Bone sialoprotein II (BSP-II)<br>Pfam-B_12103 (release 8.0). Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts  . The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone  . . 
+PF05433 Glycine zipper 2TM domain<br>Pfam-B_13382 (Rel 8.0) & Pfam-B_6 (Rel 24.0). This family includes a putative two transmembrane alpha-helical region that contains glycine zipper motifs  . This family includes  several Rickettsia genus specific 17 kDa surface antigen proteins  .. 
+PF05434 TMEM9; <br>Pfam-B_12447 (release 8.0). This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9 Swiss:Q9P0T7. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localised to the late endosomes and lysosomes  . Members of this family contain Pfam:PF03128 repeats in their N-terminal region.. 
+PF05435 Phi-29 DNA terminal protein GP3<br>Pfam-B_14111 (release 8.0). This family consists of DNA terminal protein GP3 sequences from Phi-29 like bacteriophages. DNA terminal protein GP3 is linked to the 5' ends of both strands of the genome through a phosphodiester bond between the beta-hydroxyl group of a serine residue and the 5'-phosphate of the terminal deoxyadenylate. This protein is essential for DNA replication and is involved in the priming of DNA elongation  .. 
+PF05436 Mating factor alpha precursor N-terminus<br>Pfam-B_12643 (release 8.0). This family contains the N-terminal regions of the Saccharomyces mating factor alpha precursor protein. All proteins in this family contain one or more copies Pfam:PF04648 further toward their C terminus.. 
+PF05437 Branched-chain amino acid transport protein (AzlD)<br>Pfam-B_14345 (release 8.0). This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain  .. 
+PF05438 Thyrotropin-releasing hormone (TRH)<br>Pfam-B_14384 (release 8.0). This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localised on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH  . TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans  .. 
+PF05439 Jumping translocation breakpoint protein (JTB)<br>Pfam-B_14502 (release 8.0). This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the trans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex)  . JTB has also been implicated in prostatic carcinomas  .. 
+PF05440 Tetrahydromethanopterin S-methyltransferase subunit B<br>Pfam-B_15021 (release 8.0). The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of  Methanosarcina mazei Go1 is a membrane-associated, corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump  . . 
+PF05443 ROS/MUCR transcriptional regulator protein<br>Pfam-B_1733 (release 8.0). This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid   and is necessary for succinoglycan production  . Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan  .. 
+PF05444 Protein of unknown function (DUF753)<br>Pfam-B_1957 (release 8.0). This family contains sequences with are repeated in several uncharacterised proteins from Drosophila melanogaster.. 
+PF05445 Poxvirus serine/threonine protein kinase<br>Pfam-B_1974 (release 8.0). 
+PF05448 Acetyl xylan esterase (AXE1)<br>Pfam-B_4814 (release 8.0). This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan  .. 
+PF05449 Protein of unknown function (DUF754)<br>This domain appears to be found in a group of  prophage proteins.. 
+PF05450 Nicastrin<br>Pfam-B_15452 (release 8.0). Nicastrin and presenilin are two major components of the gamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch.  Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin)  . A region featured in this family has a fold similar to human transferrin receptor (TfR, Swiss:P02786) and a bacterial aminopeptidase (Swiss:P80561). It is implicated in the pathogenesis of Alzheimer's disease  .. 
+PF05451 Phytoreovirus nonstructural protein Pns10/11<br>Pfam-B_15695 (release 8.0). This family consists of Phytoreovirus nonstructural proteins Pns10 and Pns11. Genome segment S11 of rice gall dwarf virus (RGDV), a member of Phytoreovirus encodes a putative protein of 40 kDa that exhibits approximately 37% homology at the amino acid level to the nonstructural proteins Pns10 of rice dwarf and wound tumour viruses, which are other members of Phytoreovirus  .. 
+PF05452 Clavanin<br>Pfam-B_15887 (release 8.0). This family consists of clavanin proteins from the haemocytes of the invertebrate Styela clava, a solitary tunicate. The family is made up of four alpha-helical antimicrobial peptides, clavanins A, B, C and D. The tunicate peptides resemble magainins in size, primary sequence and antibacterial activity. Synthetic clavanin A displays comparable antimicrobial activity to magainins and cecropins. The presence of alpha-helical antimicrobial peptides in the haemocytes of a urochordate suggests that such peptides are primeval effectors of innate immunity in the vertebrate lineage  .. 
+PF05453 toxin_6; <br>BmTXKS1/BmP02 toxin family. Pfam-B_16009 (release 8.0). This family consists of toxin-like peptides that are isolated from the venom of Buthus martensii Karsch scorpion. The precursor consists of 60 amino acid residues, with a putative signal peptide of 28 residues and an extra residue, and a mature peptide of 31 residues with an amidated C-terminal. The peptides share close homology with other scorpion K+ channel toxins and should present a common three-dimensional fold - the Cysteine -Stabilised alphabeta (CSalphabeta) motif  . This family acts by blocking small conductance calcium activated potassium ion channels in their victim [1,2].. 
+PF05454 Dystroglycan (Dystrophin-associated glycoprotein 1)<br>Pfam-B_15784 (release 8.0). Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and  [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear  . . 
+PF05455 GvpH<br>Pfam-B_16017 (release 8.0). This family consists of archaeal GvpH proteins which are thought to be involved in gas vesicle synthesis  .. 
+PF05456 EIF4EBP; <br>Eukaryotic translation initiation factor 4E binding protein (EIF4EBP). Pfam-B_5573 (release 8.0). This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1 ,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F  .. 
+PF05458 Cd27 binding protein (Siva)<br>Pfam-B_5606 (release 8.0). Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway  . Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis  . This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1  .. 
+PF05459 Herpesvirus transcriptional regulator family<br>Pfam-B_15401 (release 8.0). This family includes UL69 and IE63 that are transcriptional regulator proteins.. 
+PF05460 ORC6; ORC6_1; <br>Origin recognition complex subunit 6 (ORC6). Pfam-B_16189 (release 8.0). This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins.  Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organisms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in  .. 
+PF05461 Apolipoprotein L<br>Pfam-B_16464 (release 8.0). Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia  .. 
+PF05462 Dict_CAR; <br>Slime mold cyclic AMP receptor. Pfam-B_16614 (release 8.0). This family consists of cyclic AMP receptor (CAR) proteins from slime molds. CAR proteins are responsible for controlling development in Dictyostelium discoideum [1,2,3,4].. 
+PF05463 Sclerostin (SOST)<br>Pfam-B_16740 (release 8.0). This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterised by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients  .. 
+PF05464 Phi-29-like late genes activator (early protein GP4)<br>Pfam-B_16889 (release 8.0). This family consists of phi-29-like late genes activator (or early protein GP4). This protein is thought to be a positive regulator of late transcription and may function as a sigma like component of the host RNA polymerase  .. 
+PF05465 Halobacterial gas vesicle protein C (GVPC) repeat<br>Pfam-B_17013 (release 8.0). This family consists of Halobacterium gas vesicle protein C sequences which are thought to confer stability to the gas vesicle membranes [1,2].. 
+PF05466 Brain acid soluble protein 1 (BASP1 protein)<br>Pfam-B_16137 (release 8.0). This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of unknown function [1,2].. 
+PF05467 Herpesvirus glycoprotein U47<br>Pfam-B_17115 (release 8.0). 
+PF05470 eIF3c_N; <br>Eukaryotic translation initiation factor 3 subunit 8 N-terminus. Pfam-B_17447 (release 8.0). The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA  .. 
+PF05472 DNA replication terminus site-binding protein (Ter protein)<br>Pfam-B_17662 (release 8.0). This family contains several bacterial Ter proteins. The Ter protein specifically binds to DNA replication terminus sites on the host and plasmid genome and then blocks progress of the DNA replication fork  .. 
+PF05473 UL45 protein<br>Pfam-B_17674 (release 8.0) & Pfam-B_16138 (release 10.0). This family consists several UL45 proteins. The herpes simplex virus UL45 gene encodes an 18 kDa virion envelope protein whose function remains unknown. It has been suggested that the 18 kDa UL45 gene product is required for efficient growth in the central nervous system at low doses and may play an important role under the conditions of a naturally acquired infection  . This family also contains several Varicellovirus UL45 or gene 15 proteins. The Equine herpesvirus 1 UL45 protein represents a type II membrane glycoprotein which has found to be non-essential for EHV-1 growth in vitro but deletion reduces the viruses' replication efficiency  .. 
+PF05474 Semenogelin<br>Pfam-B_18147 (release 8.0). This family consists of several mammalian semenogelin (I and II) proteins. Freshly ejaculated human semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicle secreted semenogelins (Sg)  .. 
+PF05475 Chlamydia_vir; <br>Chlamydia virulence protein PGP3-D. Pfam-B_18238 (release 8.0). This family consists of Chlamydia virulence proteins which are thought to be required for growth within mammalian cells  .. 
+PF05476 PET122<br>Pfam-B_18328 (release 8.0). The nuclear PET122 gene of S. cerevisiae encodes a mitochondrial-localised protein that activates initiation of translation of the mitochondrial mRNA from the COX3 gene, which encodes subunit III of cytochrome c oxidase  . . 
+PF05477 Surfeit locus protein 2 (SURF2)<br>Pfam-B_18437 (release 8.0)  . Surfeit locus protein 2 is part of a group of at least six sequence unrelated genes (Surf-1 to Surf-6). The six Surfeit genes have been classified as housekeeping genes, being expressed in all tissue types tested and not containing a TATA box in their promoter region. The exact function of SURF2 is unknown  .. 
+PF05478 Prominin<br>Pfam-B_18226 (release 8.0). The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain  . The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration  .. 
+PF05479 Photosystem I reaction centre subunit N (PSAN or PSI-N)<br>Pfam-B_18582 (release 8.0). This family contains several Photosystem I reaction centre subunit N (PSI-N) proteins. The protein has no known function although it is localised in the thylakoid lumen  . PSI-N is a small extrinsic subunit at the lumen side and is very likely involved in the docking of plastocyanin  .. 
+PF05480 Staphylococcus haemolytic protein<br>Pfam-B_18620 (release 8.0). This family consists of several different short Staphylococcal proteins, it contains SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic activity (SLUSH), phenotypically similar to the delta-hemolysin of S. aureus  . Gonococcal growth inhibitor from Staphylococcus  act on the cytoplasmic membrane of the gonococcal cell causing cytoplasmic leakage and, eventually, death  .. 
+PF05481 Mycobacterium 19 kDa lipoprotein antigen<br>Pfam-B_19467 (release 8.0). Most of the antigens of Mycobacterium leprae and M. tuberculosis that have been identified are members of stress protein families, which are highly conserved throughout many diverse species. Of the M. leprae and M. tuberculosis antigens identified by monoclonal antibodies, all except the 18-kDa M. leprae antigen and the 19-kDa M. tuberculosis antigen are strongly cross-reactive between these two species and are coded within very similar genes [1,2].. 
+PF05482 Serendipity locus alpha protein (SRY-A)<br>Pfam-B_19519 (release 8.0). The Drosophila serendipity alpha (sry alpha) gene is specifically transcribed at the blastoderm stage, from nuclear cycle 11 to the onset of gastrulation, in all somatic nuclei  . SRY-A is required for the cellularisation of the embryo and is involved in the localisation of the actin filaments just prior to and during plasma membrane invagination  .. 
+PF05483 Synaptonemal complex protein 1 (SCP-1)<br>Pfam-B_19633 (release 8.0). Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase  .. 
+PF05484 LRV protein FeS4 cluster<br>This Iron sulphur cluster is found at the N-terminus of some proteins containing Pfam:PF01816 repeats.. 
+PF05485 THAP domain<br>The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes  .. 
+PF05486 SRP9; <br>Signal recognition particle 9 kDa protein (SRP9). Pfam-B_7787 (release 8.0). This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP  . This family also contains the homologous fungal SRP21  .. 
+PF05488 PAAR motif<br>This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins.. 
+PF05489 Tail_X; <br>Phage Tail Protein X. This domain is found in a family of phage tail proteins. Visual analysis suggests that it is related to Pfam:PF01476 (personal obs: C Yeats). The functional annotation of family members further confirms this hypothesis.. 
+PF05491 Holliday junction DNA helicase ruvB C-terminus<br>Pfam-B_844 (release 8.0). The RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein  . This family consists of the C-terminal region of the RuvB protein which is thought to be helicase DNA-binding domain. . 
+PF05493 ATP synthase subunit H <br>Pfam-B_3341 (release 8.0). ATP synthase subunit H is an extremely hydrophobic  of approximately 9 kDa  .  This subunit may be required for assembly of vacuolar  ATPase  . . 
+PF05494 Toluene tolerance, Ttg2 <br>Pfam-B_3575 (release 8.0). Toluene tolerance is mediated by increased cell membrane rigidity  resulting from changes in fatty acid and phospholipid compositions,  exclusion of toluene from the cell membrane, and removal of intracellular  toluene by degradation  .  Many proteins are involved in these processes.  This family is a transporter which shows similarity  to ABC transporters  .. 
+PF05495 CHY zinc finger<br>Pfam-B_5537 (release 7.8). This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues. We have named this domain after the N-terminal motif CXHY. This domain can be found in isolation in some proteins, but is also often associated with Pfam:PF00097.  One of the proteins in this family (Swiss:P36078) is a mitochondrial intermembrane space protein called Hot13. This protein is involved in the assembly of small TIM complexes  .. 
+PF05496 Holliday junction DNA helicase ruvB N-terminus<br>Pfam-B_844 (release 8.0). The RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein  . This family contains the N-terminal region of the protein. . 
+PF05497 Destabilase<br>Pfam-B_4147 (release 8.0). Destabilase is an endo-epsilon(gamma-Glu)-Lys isopeptidase, which cleaves  isopeptide bonds formed by transglutaminase (Factor XIIIa) between  glutamine gamma-carboxamide and the epsilon-amino group of lysine  .. 
+PF05498 Rapid ALkalinization Factor (RALF) <br>Pfam-B_4453 (release 8.0). RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root  growth and development  .. 
+PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1)<br>Pfam-B_38340 (release 8.0). DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication  .. 
+PF05501 Domain of unknown function (DUF755) <br>Pfam-B_4891 (release 8.0). This family is predominated by ORFs from Circoviridae. The function of this family remains to be determined.. 
+PF05502 Dynactin p62 family<br>Pfam-B_4912 (release 8.0). Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin [1,2].. 
+PF05503 Poxvirus G7-like <br>Pfam-B_4957 (release 8.0). 
+PF05504 Spore germination B3/ GerAC like, C-terminal <br>Pfam-B_5052 (release 8.0). The GerAC protein of the Bacillus subtilis spore is required for the  germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the  germination apparatus that respond directly to this germinant,  mediating the spore's response  .. 
+PF05505 Ebola nucleoprotein<br>Pfam-B_8475 (release 8.0). This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus  .. 
+PF05506 Domain of unknown function (DUF756)<br>This domain is found, normally as a tandem repeat, at the C-terminus of bacterial phospholipase C proteins.. 
+PF05507 Microfibril-associated glycoprotein (MAGP)<br>Pfam-B_8462 (release 8.0). This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils  . . 
+PF05508 RanGTP-binding protein<br>Pfam-B_37054 (release 8.0). The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The S. cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins  .. 
+PF05509 TraY domain<br>Pfam-B_8963 (release 8.0). This family consists of several enterobacterial TraY proteins. TraY is involved in bacterial conjugation where it is required for efficient nick formation in the F plasmid  . These proteins have a ribbon-helix-helix fold and are likely to be DNA-binding proteins.. 
+PF05510 sarcoglycan_2; <br>Sarcoglycan alpha/epsilon. Pfam-B_9181 (release 8.0). Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear  . This family contains alpha and epsilon members.. 
+PF05511 Mitochondrial ATP synthase coupling factor 6<br>Pfam-B_9347 (release 8.0). Coupling factor 6 (F6) is a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments  . . 
+PF05512 AWPM-19-like family<br>Pfam-B_6960 (release 8.0). Members of this family are 19 kDa membrane proteins. The levels of the plant protein AWPM-19 increase dramatically when there is an increase level of abscisic acid.  The increase presence of this protein leads to greater tolerance of freezing  .. 
+PF05513 TraA<br>Pfam-B_9521 (release 8.0). Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response  .. 
+PF05514 HR-like lesion-inducing <br>Pfam-B_6954 (release 8.0). Family of plant proteins that are associated with the hypersensitive response (HR) pathway of defence against  plant pathogens  .. 
+PF05515 Viral nucleic acid binding <br>Pfam-B_6916 (release 8.0). This family is common to ssRNA positive-strand viruses and are commonly described as nucleic acid binding  proteins (NABP).. 
+PF05517 p25-alpha <br>Pfam-B_6873 (release 8.0). This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase  .  It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.. 
+PF05518 Totivirus coat protein<br>Pfam-B_10221 (release 8.0). 
+PF05520 Citrus tristeza virus P18 protein<br>Pfam-B_10309 (release 8.0). 
+PF05521 Phage head-tail joining protein <br>Pfam-B_7008 (release 8.0). 
+PF05522 Metallothionein;<br>Pfam-B_1360 (release 8.0). This family consists of metallothioneins from several worm and sea urchin species. Metallothioneins are low molecular weight, cysteine rich proteins known to be involved in heavy metal detoxification and homeostasis  .. 
+PF05523 WxcM_C; <br>WxcM-like, C-terminal . Pfam-B_6950 (release 8.0). This family includes FdtA (Swiss:Q6T1W8) from Aneurinibacillus thermoaerophilus, which has been characterised as a dtdp-6-deoxy-3,4-keto-hexulose isomerase  . It also includes WxcM (Swiss:Q93S92) from Xanthomonas campestris (pv. campestris)  .. 
+PF05524 PEP-utilising enzyme, N-terminal<br>Pfam-B_69291 (release 8.0). 
+PF05525 Branched-chain amino acid transport protein<br>Pfam-B_1869 (release 8.0). This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force  .. 
+PF05526 Rhodococcus equi virulence-associated protein<br>Pfam-B_7324 (release 8.0). This family consists of several virulence-associated proteins from Rhodococcus equi. Rhodococcus equi is an important pulmonary pathogen of foals and is increasingly isolated from pneumonic infections and other infections in human immunodeficiency virus (HIV)-infected patients. Isolates from foals possess a large virulence plasmid, varying in size from 80 to 90 kb. Isolates lacking the plasmid are avirulent to foals. Little is known about the function of the plasmid apart from its encoding a virulence associated surface proteins  .. 
+PF05527 Domain of unknown function (DUF758) <br>Pfam-B_6320 (release 8.0). Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.. 
+PF05528 Coronavirus gene 5 protein<br>Pfam-B_7342 (release 8.0). Infectious bronchitis virus (IBV), a member of Coronaviridae family, has a single-stranded positive-sense RNA genome, which is 27 kb in length. Gene 5 contains two (5a and 5b) open reading frames. The function of the 5a and 5b proteins is unknown  .. 
+PF05529 B-cell receptor-associated protein 31-like <br>Pfam-B_6449 (release 8.0). Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8.  Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31  .. 
+PF05531 Nucleopolyhedrovirus P10 protein<br>Pfam-B_7343 (release 8.0) & Pfam-B_6199 (release 10.0). This family consists of several nucleopolyhedrovirus P10 proteins which are thought to be involved in the morphogenesis of the polyhedra  .. 
+PF05532 CsbD-like<br>Pfam-B_6755 (release 8.0). CsbD is a bacterial general stress response protein.  It's expression is mediated by sigma-B, an alternative sigma factor  . The role of CsbD in stress response is  unclear.. 
+PF05533 Beet yellows virus-type papain-like endopeptidase C42<br>Members of the Closteroviridae and Potyviridae families of plant positive-strand RNA viruses encode one or two papain-like leader proteinases, belonging to Merops peptidase family C42.. 
+PF05534 HicB family<br>Pfam-B_6090 (release 8.0). This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches  . . 
+PF05535 Chromadorea ALT protein<br>Pfam-B_7314 (release 8.0). This family consists of several ALT protein homologues found in nematodes. Lymphatic filariasis is a major tropical disease caused by the mosquito borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangitis and elephantiasis. Expression of alt-1 and alt-2 is initiated midway through development in the mosquito, peaking in the infective larva and declining sharply following entry into the host. ALT-1 and the closely related ALT-2 have been found to be strong candidates for a future vaccine against human filariasis  .. 
+PF05536 Neurochondrin<br>Pfam-B_7411 (release 8.0). This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain  .. 
+PF05537 Borrelia burgdorferi protein of unknown function (DUF759)<br>Pfam-B_7415 (release 8.0). This family consists of several uncharacterised proteins from the Lyme disease spirochete Borrelia burgdorferi.. 
+PF05538 Campylobacter major outer membrane protein<br>Pfam-B_7418 (release 8.0). This family consists of Campylobacter major outer membrane proteins. The major outer membrane protein (MOMP), a putative porin and a multifunction surface protein of Campylobacter jejuni, may play an important role in the adaptation of the organism to various host environments  . . 
+PF05539 Pneumovirinae attachment membrane glycoprotein G<br>Pfam-B_7428 (release 8.0). 
+PF05540 Serpulina hyodysenteriae variable surface protein<br>Pfam-B_7432 (release 8.0). This family consists of several variable surface proteins from Serpulina hyodysenteriae.. 
+PF05541 Entomopoxvirus spheroidin protein<br>Pfam-B_7488 (release 8.0). Entomopoxviruses (EPVs) are large (300-400 nm) oval-shaped viruses replicating in the cytoplasm of their insect host cells. At the end of their replicative cycle EPVs virions are occluded in a highly expressed protein called spheroidin. This protein forms large (5-20 mm long) oval-shaped occlusion bodies (OBs) called spherules. The infectious cycle of EPVs begins with the ingestion by the insect host of the spherules, their dissolution by the alkaline reducing conditions of the midgut fluid and the release of virions in the midgut lumen. The infective particles first replicate in midgut epithelial cells, then pass the gut barrier to colonise the internal tissues, mainly the fat body cells. Whilst spheroidin has been demonstrated to be non-essential for viral replication, it plays an essential role in the natural biological cycle of the virus in protecting virions from adverse environmental conditions (e.g. UV degradation) and thus improving transmission efficacy. In this respect, spheroidins are functionally similar to polyhedrins of baculoviruses or cypoviruses  .. 
+PF05542 Protein of unknown function (DUF760)<br>Pfam-B_7508 (release 8.0). This family contains several uncharacterised plant proteins.. 
+PF05543 Staphopain peptidase C47<br>Staphopains are one of four major families of  proteinases secreted by  the Gram-positive Staphylococcus aureus. These staphylococcal cysteine proteases are secreted as preproenzymes that are proteolytically cleaved to generate the mature enzyme.. 
+PF05544 Proline racemase<br>Pfam-B_7562 (release 8.0). This family consists of proline racemase (EC 5.1.1.4) proteins which catalyse the interconversion of L- and D-proline in bacteria  . This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterised as a co-factor-independent proline racemase  .. 
+PF05545 Cbb3-type cytochrome oxidase component FixQ<br>Pfam-B_7570 (release 8.0). This family consists of several Cbb3-type cytochrome oxidase components (FixQ/CcoQ). FixQ is found in nitrogen fixing bacteria. Since nitrogen fixation is an energy-consuming process, effective symbioses depend on operation of a respiratory chain with a high affinity for O2, closely coupled to ATP production. This requirement is fulfilled by a special three-subunit terminal oxidase (cytochrome terminal oxidase cbb3), which was first identified in Bradyrhizobium japonicum as the product of the fixNOQP operon  .. 
+PF05546 She9 / Mdm33 family<br>Pfam-B_35269 (Release 8.0). Members of this family are mitochondrial inner membrane proteins with a role in inner mitochondrial membrane organisation and biogenesis  .. 
+PF05547 Immune inhibitor A peptidase M6<br>The insect pathogenic  Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homologue of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae  .. 
+PF05548 Gametolysin peptidase M11<br>In the unicellular biflagellated alga, Chlamydomonas reinhardtii, gametolysin, a zinc-containing metallo-protease, is responsible for the degradation of the cell wall. Homologues of gametolysin have also been reported in the simple multicellular organism, Volvox.. 
+PF05549 Allexivirus 40kDa protein<br>Pfam-B_7591 (release 8.0). 
+PF05550 Pestivirus Npro endopeptidase C53<br>Unique to pestiviruses, the N-terminal protein encoded by the bovine viral diarrhoea virus genome is a cysteine protease (Npro) responsible for  a self-cleavage that releases the N terminus of the core protein.  This unique protease is dispensable for viral replication, and its  coding region can be replaced by a ubiquitin gene directly fused in frame to the core. . 
+PF05551 Naegl_SSU_RRNA; DUF1519;<br>Zinc-binding loop region of homing endonuclease. Pfam-B_7681 (release 8.0). This domain   is the short zinc-binding loops region of a number of much longer chain homing endonucleases. Such loops are probably stabilised by the zinc and may be viewed as small but separate domains. The common structural feature of these domains is that at least three zinc ligands lie very close to each other in the sequence and are not incorporated into regular secondary structural elements. The biological roles played by these small zinc-binding domains are presently unknown  .. 
+PF05552 tm_helix; <br>This alignment represents a conserved transmembrane helix as well as some flanking sequence. It is often found in association with Pfam:PF00924.. 
+PF05553 Cotton fibre expressed protein<br>Pfam-B_7657 (release 8.0). This family consists of several plant proteins of unknown function. Three of the sequences (from Gossypium hirsutum) in this family are described as cotton fibre expressed proteins  . The remaining sequences, found in Arabidopsis thaliana, are uncharacterised.. 
+PF05554 Viral hemorrhagic septicemia virus non-virion protein<br>Pfam-B_7684 (release 8.0). This family consists of several viral hemorrhagic septicemia virus non-virion (Nv) proteins. The NV protein is a nonstructural protein absent from mature virions although it is present in infected cells. The function of this protein is unknown  .. 
+PF05555 Coxiella burnetii protein of unknown function (DUF762)<br>Pfam-B_7710 (release 8.0). This family consists several of several uncharacterised proteins from the bacterium Coxiella burnetii. Coxiella burnetii is the causative agent of the Q fever disease.. 
+PF05556 Calcineurin-binding protein (Calsarcin)<br>Pfam-B_7783 (release 8.0). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation  . Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin  .. 
+PF05557 Mitotic checkpoint protein<br>Pfam-B_7761 (release 8.0). This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated  . . 
+PF05558 DREPP plasma membrane polypeptide<br>Pfam-B_7798 (release 8.0). This family contains several plant plasma membrane proteins termed DREPPs as they are developmentally regulated plasma membrane polypeptides  .. 
+PF05559 Protein of unknown function (DUF763)<br>Pfam-B_7805 (release 8.0). This family consists of several uncharacterised bacterial and archaeal proteins of unknown function.. 
+PF05560 Bacillus thuringiensis P21 molecular chaperone protein<br>Pfam-B_7820 (release 8.0). This family contains several Bacillus thuringiensis P21 proteins. These proteins are thought to be molecular chaperones and have mosquitocidal properties [1,2].. 
+PF05561 Borrelia burgdorferi protein of unknown function (DUF764)<br>Pfam-B_7823 (release 8.0). This family consists of proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).. 
+PF05562 Cold acclimation protein WCOR413<br>Pfam-B_7803 (release 8.0). This family consists of several WCOR413-like plant cold acclimation proteins.. 
+PF05563 Sal_SpvD; <br>Salmonella plasmid virulence protein SpvD. Pfam-B_7864 (release 8.0). This family consists of several SpvD plasmid virulence proteins from different Salmonella species.. 
+PF05564 Dormancy/auxin associated protein<br>Pfam-B_7941 (release 8.0). This family contains several plant dormancy-associated and auxin-repressed proteins the function of which are poorly understood  .. 
+PF05565 Siphovirus Gp157<br>Pfam-B_7948 (release 8.0). This family contains both viral and bacterial proteins which are related to the Gp157 protein of the Streptococcus thermophilus SFi bacteriophages. It is thought that bacteria possessing the gene coding for this protein have an increased resistance to the bacteriophage .. 
+PF05566 Orthopoxvirus interleukin 18 binding protein<br>Pfam-B_7955 (release 8.0). Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasises the importance of IL-18 in response to viral infections  .. 
+PF05567 Neisseria PilC beta-propeller domain<br>Pfam-B_7966 (release 8.0). This family consists of several PilC protein sequences from Neisseria gonorrhoeae and N. meningitidis. PilC is a phase-variable protein associated with pilus-mediated adherence of pathogenic Neisseria to target cells  .\.  This domain has been shown to adopt a beta-propeller structure  .. 
+PF05568 African swine fever virus J13L protein<br>Pfam-B_7998 (release 8.0). This family consists of several African swine fever virus J13L proteins.. 
+PF05569 BlaR1 peptidase M56<br>Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein       and a transcriptional repressor.  The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains.  The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. Homologues to this peptidase domain, which corresponds to Merops family  M56, are also found in a number of other bacterial genome sequences.. 
+PF05570 Circovirus protein of unknown function (DUF765)<br>Pfam-B_8063 (release 8.0). This family consists of several short (27-30aa) porcine and bovine circovirus ORF6 proteins of unknown function.. 
+PF05571 Protein of unknown function (DUF766)<br>Pfam-B_8021 (release 8.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF05572 Peptidase_M46; <br>Pregnancy-associated plasma protein-A. Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II.  Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.. 
+PF05573 NosL<br>Pfam-B_8116 (release 8.0). NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallo-centre assembly  .. 
+PF05575 Vibrio cholerae RfbT protein<br>Pfam-B_8029 (release 8.0). This family consists of several RfbT proteins from Vibrio cholerae. It has been found that genetic alteration of the rfbT gene is responsible for serotype conversion of Vibrio cholerae O1   and determines the difference between the Ogawa and Inaba serotypes, in that the presence of rfbT is sufficient for Inaba-to-Ogawa serotype conversion  .. 
+PF05576 PS-10 peptidase S37<br>These serine proteases have been found in Streptomyces species.. 
+PF05577 Serine carboxypeptidase S28<br>These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.. 
+PF05578 Pestivirus NS3 polyprotein peptidase S31<br>These serine peptidases are involved in processing of the flavivirus polyprotein.. 
+PF05579 Equine arteritis virus serine endopeptidase S32<br>Serine peptidases involved in processing nidovirus polyprotein.. 
+PF05580 SpoIVB peptidase S55<br>The protein SpoIVB plays a key role in signalling in the final sigma-K checkpoint of Bacillus subtilis. . 
+PF05581 Peptidase_S38; <br>Vibrio chemotaxis protein N terminus. This domain is found at the N terminus of several methyl-accepting chemotaxis proteins from Vibrio species.. 
+PF05582 YabG peptidase U57<br>YabG is a protease involved in the proteolysis and maturation of SpoIVA and YrbA proteins, conserved with the cortex and/or coat assembly by Bacillus subtilis.. 
+PF05584 Sulfolobus plasmid regulatory protein<br>Pfam-B_8140 (release 8.0). This family consists of several plasmid regulatory proteins from the extreme thermophilic and acidophilic archaea Sulfolobus.. 
+PF05585 Peptidase_A16; <br>Putative peptidase (DUF1758). This is a family of nematode proteins of unknown function. However, it seems likely that these proteins act as aspartic peptidases.. 
+PF05586 Anthrax receptor C-terminus region<br>This region is found in the putatively cytoplasmic C-terminus of the anthrax receptor.. 
+PF05587 Anthrax receptor extracellular domain<br>This region is found in the putatively extracellular N-terminal half of the anthrax receptor. It is  probably part of the Ig superfamily and most closely related to Pfam:PF01833 (personal obs: C Yeats).. 
+PF05588 botulinum_HA-17; <br>Clostridium botulinum HA-17 protein. Pfam-B_8286 (release 8.0). This family consists of several Clostridium botulinum hemagglutinin (HA) subcomponents. Clostridium botulinum type D strain 4947 produces two different sizes of progenitor toxins (M and L) as intact forms without proteolytic processing. The M toxin is composed of neurotoxin (NT) and nontoxic-nonhemagglutinin (NTNHA), whereas the L toxin is composed of the M toxin and hemagglutinin (HA) subcomponents (HA-70, HA-17, and HA-33)  .. 
+PF05589 Protein of unknown function (DUF768)<br>Pfam-B_8463 (release 8.0). This family consists of several uncharacterised hypothetical proteins from Rhizobium loti.. 
+PF05590 Xylella fastidiosa protein of unknown function (DUF769)<br>Pfam-B_8396 (release 8.0). This family consists of several uncharacterised hypothetical proteins of unknown function from Xylella fastidiosa, the organism that causes Pierce's disease in plants.. 
+PF05591 Protein of unknown function (DUF770)<br>Pfam-B_8473 (release 8.0). This family consists of several proteins of unknown function from various bacterial species.. 
+PF05592 bac_rhamnosid;<br>Bacterial alpha-L-rhamnosidase. Pfam-B_8527 (release 8.0). This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria  .. 
+PF05593 RHS Repeat<br>RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding (e.g.  ). Note that this model may not find all the repeats in a protein and that it covers  two RHS repeats.. 
+PF05594 haemagg_repeats; <br>Haemagluttinin repeat. This highly divergent repeat occurs in number of proteins implicated in cell aggregation  . The Pfam alignment probably contains three such repeats (personal obs: C Yeats). These are likely to have a beta-helical structure.. 
+PF05595 Domain of unknown function (DUF771) <br>Pfam-B_7023 (release 8.0). Family of uncharacterised ORFs found in  Bacteriophage and Lactococcus lactis. . 
+PF05596 Taeniidae antigen<br>Pfam-B_8569 (release 8.0). This family consists of several antigen proteins from Taenia and Echinococcus (tapeworm) species.. 
+PF05597 Poly(hydroxyalcanoate) granule associated protein (phasin)<br>Pfam-B_8339 (release 8.0). Polyhydroxyalkanoates (PHAs) are storage polyesters synthesised by various bacteria as intracellular carbon and energy reserve material. PHAs are accumulated as water-insoluble inclusions within the cells. This family consists of the phasins PhaF and PhaI which act as a transcriptional regulator of PHA biosynthesis genes. PhaF has been proposed to repress expression of the phaC1 gene and the phaIF operon  .. 
+PF05598 Transposase domain (DUF772)<br>Pfam-B_8195 (release 8.0). This presumed domain is found at the N-terminus of many proteins found in transposons.. 
+PF05599 Deltaretrovirus Tax protein<br>Pfam-B_8606 (release 8.0). This family consists of Rex/Tax proteins from human and simian T-cell leukaemia viruses. The exact function of these proteins is unknown. Tax is the viral transactivator; is it a nuclear phosphoprotein that interacts with CREB, coactivator CBP/p300 and PCAF to form a multiprotein complex, which activates viral LTR and stimulates virus expression. Tax is also involved in deregulated expression of numerous cellular genes leading to T-cell leukaemia. Rex is a nucleolar post transcriptional regulator that facilitates export to the cytoplasm of viral RNA not or incompletely spliced [personal communication, Dr. S Nicot].. 
+PF05600 Protein of unknown function (DUF773)<br>Pfam-B_8595 (release 8.0). This family contains several eukaryotic sequences which are thought to be CDK5 activator-binding proteins, however, the function of this family is unknown.. 
+PF05602 Cleft lip and palate transmembrane protein 1 (CLPTM1)<br>Pfam-B_8636 (release 8.0). This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family  . This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis  .. 
+PF05603 Protein of unknown function (DUF775)<br>Pfam-B_8676 (release 8.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF05604 Protein of unknown function (DUF776)<br>Pfam-B_8747 (release 8.0). This family consists of several highly related mouse and human proteins of unknown function.. 
+PF05605 Di19;<br>Drought induced 19 protein (Di19), zinc-binding. Pfam-B_8581 (release 8.0). This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought  . This domain is a zinc-binding domain.. 
+PF05606 Borrelia burgdorferi protein of unknown function (DUF777)<br>Pfam-B_8755 (release 8.0). This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).. 
+PF05608 Protein of unknown function (DUF778)<br>Pfam-B_8777 (release 8.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF05609 Lamina-associated polypeptide 1C (LAP1C)<br>Pfam-B_8782 (release 8.0). This family contains rat LAP1C proteins and several uncharacterised highly related sequences from both mice and humans. LAP1s (lamina-associated polypeptide 1s) are type 2 integral membrane proteins with a single membrane-spanning region of the inner nuclear membrane  . LAP1s bind to both A- and B-type lamins and have a putative role in the membrane attachment and assembly of the nuclear lamina  .. 
+PF05610 Protein of unknown function (DUF779)<br>Pfam-B_8830 (release 8.0). This family consists of several bacterial proteins of unknown function.. 
+PF05611 Caenorhabditis elegans protein of unknown function (DUF780)<br>Pfam-B_8886 (release 8.0). This family consists of several short C. elegans proteins of unknown function.. 
+PF05612 Mouse protein of unknown function (DUF781)<br>Pfam-B_8891 (release 8.0). This family consists of uncharacterised mouse proteins of unknown function.. 
+PF05613 Human herpesvirus U15 protein<br>Pfam-B_8900 (release 8.0). 
+PF05614 Circovirus protein of unknown function (DUF782)<br>Pfam-B_8909 (release 8.0). This family consists of porcine and bovine circovirus proteins of unknown function.. 
+PF05615 DUF783; <br>Tho complex subunit 7. Pfam-B_8919 (release 8.0). The Tho complex is involved in transcription elongation and mRNA export from the nucleus.. 
+PF05616 Neisseria meningitidis TspB protein<br>Pfam-B_8925 (release 8.0). This family consists of several Neisseria meningitidis TspB virulence factor proteins.. 
+PF05617 DUF784;<br>Pfam-B_8935 (release 8.0). Both DUF784 and DUF1278 members are found to be expressed in the plant embryo sac and are regulated by the Myb98 transcription factor. Computational analysis has revealed that they are homologous to the plant prolamin superfamily (Protease inhibitor-seed storage-LTP family, Pfam:PF00234)  . In contrast to the typical prolamin members that have eight conserved Cys residues forming four pairs of disulfide bonds, both DUF784 and DUF1278 domains only contain six conserved Cys residues that may form three pairs of disulfide bonds. These two domains may have potential functions in lipid transfer or protection during plant embryo sac development and reproduction  .  This family has been merged with the DUF1278 family.. 
+PF05618 DUF785;<br>Putative ATP-dependant zinc protease. Pfam-B_8936 (release 8.0). Proteins in this family are annotated as being ATP-dependant zinc proteases.. 
+PF05619 Borrelia burgdorferi protein of unknown function (DUF787)<br>Pfam-B_9013 (release 8.0). This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete). . 
+PF05620 Protein of unknown function (DUF788)<br>Pfam-B_9014 (release 8.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF05621 Bacterial TniB protein<br>Pfam-B_9028 (release 8.0). This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein   which is involved in Tn5053 mercury resistance transposition  .. 
+PF05622 HOOK protein<br>Pfam-B_8981 (release 8.0). This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes  , whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head  .. 
+PF05623 Protein of unknown function (DUF789)<br>Pfam-B_9113 (release 8.0). This family consists of several plant proteins of unknown function.. 
+PF05624 LISCH7; <br>Lipolysis stimulated receptor (LSR). Pfam-B_9152 (release 8.0). The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids  .  It is thought to be involved in the clearance of triglyceride-rich lipoproteins, and has been shown in mice to be critical for liver and embryonic development  .. 
+PF05625 PAXNEB protein<br>Moxon SJ, Mistry J, Wood V. Pfam-B_9269 (release 8.0). PAXNEB or PAX6 neighbour is found in several eukaryotic organisms.  PAXNED is an RNA polymerase II Elongator protein subunit  .  It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme.  The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity  . This protein family has a P-loop motif. However its sequence has degraded in many members of the family.. 
+PF05626 Protein of unknown function (DUF790)<br>Pfam-B_9309 (release 8.0). This family consists of several hypothetical archaeal proteins of unknown function.. 
+PF05627 NOI; <br>Cleavage site for pathogenic type III effector avirulence factor Avr. Pfam-B_9342 (release 8.0). This domain is conserved in small families of otherwise unrelated proteins in both mono-cots and di-cots, suggesting that it has a conserved, plant-specific function. It is found both in the plant RIN4 (resistance R membrane-bound host-target protein) where it appears to contribute to the binding of the protein to both RCS (AvrRpt2 auto-cleavage site) and AvrB, the virulence factor from the infecting bacterium  . The cleavage site for the AvrRpt2 avirulence protein would appear to be the sequence motifs VPQFGDW and LPKFGEW, both of which are highly conserved within the domain  .. 
+PF05628 Borrelia membrane protein P13<br>Pfam-B_8766 (release 8.0). This family consists of P13 proteins from Borrelia species. P13 is a 13kDa integral membrane protein which is post-translationally processed at both ends and modified by an unknown mechanism  .. 
+PF05629 Nanovirus component 8 (C8) protein<br>Pfam-B_9354 (release 8.0). This family consists of a group of 17.4 kDa nanovirus proteins which are highly related to the faba bean necrotic yellows virus component 8 protein whose function is unknown  .. 
+PF05630 Necrosis inducing protein (NPP1)<br>Pfam-B_9369 (release 8.0). This family consists of several NPP1 like necrosis inducing proteins from oomycetes, fungi and bacteria. Infiltration of NPP1 into leaves of Arabidopsis thaliana plants result in transcript accumulation of pathogenesis-related (PR) genes, production of ROS and ethylene, callose apposition, and HR-like cell death  . . 
+PF05631 Protein of unknown function (DUF791)<br>Pfam-B_9328 (release 8.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF05632 Borrelia burgdorferi protein of unknown function (DUF792)<br>Pfam-B_9387 (release 8.0). This family consists of several hypothetical proteins from the Lyme disease spirochete Borrelia burgdorferi.. 
+PF05633 Protein of unknown function (DUF793)<br>Pfam-B_9395 (release 8.0). This family consists of several plant proteins of unknown function.. 
+PF05634 DUF794;<br>Moxon SJ, Eberhardt R, Barkan A. Pfam-B_9606 (release 8.0). This domain contains conserved cysteine and histidine residues  . It resembles zinc fingers, and binds to zinc  . This domain functions as an RNA-binding domain  .. 
+PF05635 Ribosomal_S23p;<br>23S rRNA-intervening sequence protein. Moxon SJ, Eberhardt R. Pfam-B_9648 (release 8.0). This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes [1-3]. It folds into an anti-parallel four-helix bundle and forms homopentamers  .. 
+PF05636 DUF795;<br>HIGH Nucleotidyl Transferase. Moxon SJ, Anantharaman V. Pfam-B_9692 (release 8.0). This family consists of HIGH Nucleotidyl Transferases. 
+PF05637 galactosyl transferase GMA12/MNN10 family<br>Pfam-B_6000 (release 8.0). This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of C. elegans homologues where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.. 
+PF05638 Protein of unknown function (DUF796)<br>Pfam-B_9698 (release 8.0). This family consists of several bacterial proteins of unknown function.. 
+PF05639 DUF797;<br>Pfam-B_9797 (release 8.0). This family consists of several short bacterial proteins formely known as (DUF797).  It was recently shown that Mycobacterium tuberculosis contains a small protein, Pup (Rv2111c), that is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl carrier protein (FabD)  . Pupylation of FabD was shown to result in its recruitment to the mycobacterial proteasome and subsequent degradation analogous to eukaryotic ubiquitin-conjugated proteins. Searches recovered Pup orthologs in all major actinobacteria lineages including the basal bifidobacteria and also sporadically in certain other bacterial lineages.   The Pup proteins were all between 50-90 residues in length and a multiple alignment shows that they all contain a conserved motif with a G [EQ] signature at the C-terminus. Thus, all of them are suitable for conjugation via the terminal glutamate or the deamidated glutamine (as shown in the case of the Mycobacterium Pup  ). The conserved globular core of Pup is predicted to form a bihelical unit with the extreme C-terminal 6-7 residues forming a tail in the extended conformation. Thus, Pup is structurally unrelated to the ubiquitin fold and has convergently evolved the function of protein modifier.. 
+PF05640 DUF798; <br>Na,K-Atpase Interacting protein. Pfam-B_9801 (release 8.0). NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localise to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterised domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer  .. 
+PF05641 Agenet domain<br>Pfam-B_2551 (release 8.0). This domain is related to the TUDOR domain Pfam:PF00567  . The function of the agenet domain is unknown. This family currently only matches one of the two Agenet domains in the FMR proteins  .. 
+PF05642 Sporozoite P67 surface antigen<br>Pfam-B_8657 (release 8.0). This family consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. The antigen has been shown to contain five distinct linear peptide sequences recognised by sporozoite-neutralising murine monoclonal antibodies  .. 
+PF05643 Putative bacterial lipoprotein (DUF799)<br>Pfam-B_9829 (release 8.0). This family consists of several bacterial proteins of unknown function. Some of the family members are described as putative lipoproteins.. 
+PF05644 DUF800;<br>Mitochondrial and peroxisomal fission factor Mff. Moxon SJ, Eberhardt R. Pfam-B_9868 (release 8.0). This protein has a role in mitochondrial and peroxisomal fission  .. 
+PF05645 RNA polymerase III subunit RPC82<br>Pfam-B_9884 (release 8.0). This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa  .. 
+PF05647 DUF801;<br>Tandem-repeating region of mucin, epiglycanin-like. Pfam-B_1480 (release 8.0) Pfam-B_13922 (release 26.0). The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus  . It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells  . Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21  . This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).. 
+PF05648 Peroxisomal biogenesis factor 11 (PEX11)<br>Pfam-B_2629 (release 8.0). This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.. 
+PF05649 Peptidase family M13<br>M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure  regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk. . 
+PF05650 Domain of unknown function (DUF802)<br>This region is found as two or more repeats in a small number of hypothetical proteins.. 
+PF05651 Putative sugar diacid recognition<br>This region is found in several proteins characterised as carbohydrate diacid regulators (e.g. Swiss:P36047). An HTH DNA-binding motif is found at the C-terminus of these proteins suggesting that this region includes the sugar recognition region.. 
+PF05652 Scavenger mRNA decapping enzyme (DcpS) N-terminal<br>Pfam-B_9894 (release 8.0). This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the N-terminal domain of these proteins. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway.. 
+PF05653 DUF803;<br>Magnesium transporter NIPA. Moxon SJ, Eberhardt R. Pfam-B_9876 (release 8.0). NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters [1,2].. 
+PF05655 Pseudomon_AvrD; <br>Pseudomonas avirulence D protein (AvrD). Pfam-B_9946 (release 8.0). This family consists of several avirulence D (AvrD) proteins primarily found in Pseudomonas syringae [1,2].. 
+PF05656 Protein of unknown function (DUF805)<br>Pfam-B_2800 (release 8.0). This family consists of several bacterial proteins of unknown function.. 
+PF05657 Protein of unknown function (DUF806)<br>Pfam-B_7291 (release 8.0). This family consists of several Siphovirus and Lactococcus proteins of unknown function. The viral sequences are thought to be tail component proteins.. 
+PF05658 Hep_Hag;<br>Head domain of trimeric autotransporter adhesin. This seven residue repeat makes up the majority sequence of a family of bacterial haemagglutinins and invasins. The representative alignment contains four repeats.. 
+PF05659 Arabidopsis broad-spectrum mildew resistance protein RPW8<br>Pfam-B_7373 (release 8.0). This family consists of several broad-spectrum mildew resistance proteins from Arabidopsis thaliana. Plant disease resistance (R) genes control the recognition of specific pathogens and activate subsequent defence responses. The Arabidopsis thaliana locus Resistance To Powdery Mildew 8 (RPW8) contains two naturally polymorphic, dominant R genes, RPW8.1 and RPW8.2, which individually control resistance to a broad range of powdery mildew pathogens. They induce localised, salicylic acid-dependent defences similar to those induced by R genes that control specific resistance. Apparently, broad-spectrum resistance mediated by RPW8 uses the same mechanisms as specific resistance [1,2].. 
+PF05660 Coxiella burnetii protein of unknown function (DUF807)<br>Pfam-B_7114 (release 8.0). This family consists of several proteins of unknown function from Coxiella burnetii (the causative agent of a zoonotic disease called Q fever).. 
+PF05661 Protein of unknown function (DUF808)<br>Pfam-B_7112 (release 8.0). This family consists of several bacterial proteins of unknown function.. 
+PF05662 HIM;<br>Coiled stalk of trimeric autotransporter adhesin. This short motif is found in invasins and haemagglutinins, normally associated with (Pfam:PF05658).. 
+PF05663 Protein of unknown function (DUF809)<br>Pfam-B_7264 (release 8.0). This family consists of several proteins of unknown function Raphanus sativus (Radish) and Brassica napus (Rape).. 
+PF05664 Protein of unknown function (DUF810)<br>Pfam-B_5709 (release 8.0). This family consists of several plant proteins of unknown function.. 
+PF05666 Fels-1 Prophage Protein-like<br>
+PF05667 Protein of unknown function (DUF812)<br>Pfam-B_7417 (release 8.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF05669 SOH1; <br>Pfam-B_7443 (release 8.0). The family consists of Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant   and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes  . . 
+PF05670 Domain of unknown function (DUF814)<br>Pfam-B_738 (Release 8.0). This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity  .  Hence the activity of this C-terminal domain is unknown. This domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.. 
+PF05671 GETHR pentapeptide repeat (5 copies)<br>Pfam-B_8059 (release 8.0). 
+PF05672 E-MAP-115; <br>MAP7 (E-MAP-115) family. Pfam-B_8157 (release 8.0). The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin  . The binding of this microtubule associated protein is nucleotide independent  .. 
+PF05673 Protein of unknown function (DUF815)<br>Pfam-B_6403 (release 8.0). This family consists of several bacterial proteins of unknown function.. 
+PF05674 Baculovirus protein of unknown function (DUF816)<br>Pfam-B_7178 (release 8.0). This family includes proteins that are about 200 amino acids in length.  The proteins are all from baculoviruses. This family includes ORF107 from Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) and a variety of other numbered ORF proteins, such as ORF52 Swiss:Q91F03, ORF140 Swiss:Q9YMI8. The function of these proteins is unknown.. 
+PF05675 Protein of unknown function (DUF817)<br>Pfam-B_7331 (release 8.0). This family consists of several bacterial proteins of unknown function.. 
+PF05676 NDUFB7; <br>NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7). Pfam-B_7077 (release 8.0). This family consists of several NADH-ubiquinone oxidoreductase B18 subunit proteins from different eukaryotic organisms. Oxidative phosphorylation is the well-characterised process in which ATP, the principal carrier of chemical energy of individual cells, is produced due to a mitochondrial proton gradient formed by the transfer of electrons from NADH and FADH2 to molecular oxygen. The oxidative phosphorylation (OXPHOS) system is located in the mitochondrial inner membrane and consists of five multi-subunit enzyme complexes and two small electron carriers: coenzyme Q10 and cytochrome C. At least 70 structural proteins involved in the formation of the whole OXPHOS system are encoded by nuclear genes, whereas 13 structural proteins are encoded by the mitochondrial genome. Deficiency of NADH ubiquinone oxidoreductase, the first enzyme complex of the mitochondrial respiratory chain, is one of the most frequent causes of human mitochondrial encephalomyopathies  .. 
+PF05677 Chlamydia CHLPS protein (DUF818)<br>Pfam-B_7510 (release 8.0). This family consists of several Chlamydia CHLPS proteins, the function of which are unknown.. 
+PF05678 VQ motif<br>Pfam-B_7960 (release 8.0). 
+PF05679 Chondroitin N-acetylgalactosaminyltransferase<br>Pfam-B_8249 (release 8.0). 
+PF05680 ATP synthase E chain<br>Pfam-B_6116 (release 8.0). This family consists of several ATP synthase E chain sequences which are components of the CF(0) subunit  .. 
+PF05681 Fumarate hydratase (Fumerase)<br>Pfam-B_2085 (release 8.0). This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre  .. 
+PF05683 Fumarase C-terminus<br>Pfam-B_2085 (release 8.0). This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth  .. 
+PF05684 Protein of unknown function (DUF819)<br>Pfam-B_9034 (release 8.0). This family contains proteins of unknown function from archaeal, bacterial and plant species.. 
+PF05685 DUF820;<br>Putative restriction endonuclease. Pfam-B_7809 (release 8.0) & Pfam-B_8730 (release 14.0). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria.  The proteins are found sporadically in other bacteria.  A small number of member proteins also contain Pfam:PF02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.. 
+PF05686 DUF821;<br>Glycosyl transferase family 90. Pfam-B_6682 (Release 8.0) & Pfam-B_7101 (Release 8.0). This family of glycosyl transferases are specifically (mannosyl) glucuronoxylomannan/galactoxylomannan -beta 1,2-xylosyltransferases, EC:2.4.2.-.. 
+PF05687 DUF822; Peptidase_M15_2; <br>Plant protein of unknown function (DUF822). Pfam-B_7149 (release 8.0). This family consists of the N terminal regions of several plant proteins of unknown function.. 
+PF05688 Salmonella repeat of unknown function (DUF824)<br>Pfam-B_2973 (release 8.0). This family consists of several repeated sequences of around 45 residues.. 
+PF05689 Salmonella repeat of unknown function (DUF823)<br>Pfam-B_2973 (release 8.0). This family consists of a series of repeated sequences (of around 180 residues) which are found in Salmonella typhimurium and Salmonella typhi. Sequences from this family are almost always found with Pfam:PF05688.. 
+PF05690 Thiazole biosynthesis protein ThiG<br>Pfam-B_1138 (release 8.0). This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway  .. 
+PF05691 Raffinose synthase or seed imbibition protein Sip1<br>Moxon SJ, Eberhardt R. Pfam-B_3204 (release 8.0). This family consists of several raffinose synthase proteins, also known as seed imbibition (Sip1) proteins. Raffinose (O-alpha- D-galactopyranosyl- (1-->6)- O-alpha- D-glucopyranosyl-(1<-->2)- O-beta- D-fructofuranoside) is a widespread oligosaccharide in plant seeds and other tissues. Raffinose synthase (EC:2.4.1.82) is the key enzyme that channels sucrose into the raffinose oligosaccharide pathway  . Raffinose family oligosaccharides (RFOs) are ubiquitous in plant seeds and are thought to play critical roles in the acquisition of tolerance to desiccation and seed longevity. Raffinose synthases are alkaline alpha-galactosidases and are solely responsible for RFO breakdown in germinating maize seeds, whereas acidic galactosidases appear to have other functions  .\.    Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K  . This family includes enzymes from GH36C.. 
+PF05692 Mycoplasma haemagglutinin<br>Pfam-B_3547 (release 8.0). This family consists of several haemagglutinin sequences from Mycoplasma synoviae and Mycoplasma gallisepticum. The major plasma membrane proteins, pMGAs, of Mycoplasma gallisepticum are cell adhesin (hemagglutinin) molecules. It has been shown that the genetic determinants that code for the haemagglutinins are organised into a large family of genes and that only one of these genes is predominately expressed in any given strain [1,2,3].. 
+PF05693 Glycogen synthase<br>Pfam-B_2874 (release 8.0). This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3 [1,2]. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P)  .. 
+PF05694 56kDa selenium binding protein (SBP56)<br>Pfam-B_2816 (release 8.0). This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 participates in late stages of intra-Golgi protein transport  . The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role and can be implicated in controlling the oxidation/reduction status of target proteins, in vesicular Golgi transport  .. 
+PF05695 Plant protein of unknown function (DUF825)<br>Pfam-B_8370 (release 8.0). This family consists of several plant proteins greater than 1000 residues in length. The function of this family is unknown.. 
+PF05696 Protein of unknown function (DUF826)<br>Pfam-B_7303 (release 8.0). This family consists of several enterobacterial and siphoviral sequences of unknown function.. 
+PF05697 Trigger;<br>Bacterial trigger factor protein (TF). Pfam-B_8447 (release 8.0). In the E. coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains  . This family represents the N-terminal region of the protein.. 
+PF05698 Bacterial trigger factor protein (TF) C-terminus<br>Pfam-B_8447 (release 8.0). In the E. coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains  . This family represents the C-terminal region of the protein.. 
+PF05699 hATC;<br>hAT family C-terminal dimerisation region. This dimerisation region is found at the C terminus of the  transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerisation region forms extremely stable dimers in vitro  .. 
+PF05700 Breast carcinoma amplified sequence 2 (BCAS2)<br>Pfam-B_7922 (release 8.0). This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins  . BCAS2 is a putative spliceosome associated protein  .. 
+PF05701 DUF827;<br>Weak chloroplast movement under blue light. Pfam-B_6516 (release 8.0). WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments  .  Thus several member-sequences are described as "myosin heavy chain-like".. 
+PF05702 Herpesvirus UL49.5 envelope/tegument protein<br>Pfam-B_7354 (release 8.0). UL49.5 protein consists of 98 amino acids with a calculated molecular mass of 10,155 Da. It contains putative signal peptide and transmembrane domains but lacks a consensus sequence for N glycosylation. UL49.5 protein is an O-glycosylated structural component of the viral envelope  .. 
+PF05703 DUF828;<br>Moxon SJ, Eberhardt R. Pfam-B_7298 (release 8.0). This domain is frequently found at the N-terminus of proteins containing Pfam:PF08458 at the C-terminus. It is a component of the auto-regulatory loop which enables auxin canalisation by recruitment of the PIN1 auxin efflux protein to the cell membrane  .. 
+PF05704 Capsular polysaccharide synthesis protein<br>Pfam-B_7575 (release 8.0). This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae  . . 
+PF05705 Eukaryotic protein of unknown function (DUF829)<br>Pfam-B_7638 (release 8.0). This family consists of several uncharacterised eukaryotic proteins.. 
+PF05706 Cyclin-dependent kinase inhibitor 3 (CDKN3)<br>Pfam-B_5217 (release 8.0). This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner [1,2].. 
+PF05707 Zonular occludens toxin (Zot)<br>Pfam-B_3320 (release 8.0). This family consists  of bacterial and viral proteins which are very similar to the Zonular occludens toxin (Zot). Zot is elaborated by bacteriophages present in toxigenic strains of Vibrio cholerae. Zot is a single polypeptide chain of 44.8 kDa, with the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through mucosal barriers [1,2]. 
+PF05708 Orthopoxvirus protein of unknown function (DUF830)<br>Pfam-B_5425 (release 8.0). This family consists of several Orthopoxvirus proteins of unknown function.. 
+PF05709 Phage tail protein<br>Pfam-B_5084 (release 8.0) & Pfam-B_10063 (release 10.0). This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.. 
+PF05710 Coiled coil<br>This region is found in a group of Dictyostelium discoideum proteins.  It is likely to form a coiled-coil. Some of the proteins are regulated by cyclic AMP and are expressed late in development ( ).. 
+PF05711 Macrocin-O-methyltransferase (TylF)<br>Pfam-B_5055 (release 8.0). This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the swine industry. It is produced by several Streptomyces species. As with other macrolides, the antibiotic activity of tylosin is due to the inhibition of protein biosynthesis by a mechanism that involves the binding of tylosin to the ribosome, preventing the formation of the mRNA-aminoacyl-tRNA-ribosome complex  . The structure of one representative sequence from this family, NovP, shows it to be an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyses the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the mature antibiotic. It is likely that the key structural features of NovP are common to the rest of the family and include: a helical 'lid' region that gates access to the co-substrate binding pocket and an active centre that contains a 3-Asp putative metal binding site. A further conserved Asp probably acts as the general base that initiates the reaction by de-protonating the 4-OH group of the noviose unit  .. 
+PF05712 MRG<br>Moxon SJ, Mistry J, Wood V. Pfam-B_5530 (release 8.0). This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation   .  It contains 2 chromo domains and a leucine zipper motif  .. 
+PF05713 Bacterial mobilisation protein (MobC)<br>Pfam-B_2832 (release 8.0). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region  . The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localised DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA  . . 
+PF05714 Borrelia_lipo; <br>Borrelia burgdorferi virulent strain associated lipoprotein. Pfam-B_7866 (release 8.0). This family consists of several virulent strain associated lipoproteins from the Lyme disease spirochete Borrelia burgdorferi.. 
+PF05715 Zf_piccolo; <br>This (predicted) Zinc finger is found in the  bassoon and piccolo proteins (e.g. Swiss:Q9JKS6). There are eight conserved cysteines, suggesting  that it coordinates two zinc ligands.. 
+PF05716 A-kinase anchor protein 110 kDa (AKAP 110)<br>Pfam-B_5702 (release 8.0). This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction  .. 
+PF05717 Transposase_34;<br>IS66 Orf2 like protein. Pfam-B_5707 (release 8.0). This protein is found in insertion sequences related to IS66.  The function of these proteins is uncertain, but they are probably essential for transposition  .. 
+PF05718 Poxvirus intermediate transcription factor<br>Pfam-B_5843 (release 8.0). This family consists of several highly related Poxvirus sequences which are thought to be intermediate transcription factors.. 
+PF05719 Golgi phosphoprotein 3 (GPP34)<br>Pfam-B_7957 (release 8.0). This family consists of several eukaryotic GPP34 like proteins. GPP34 localises to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking  .. 
+PF05720 Cell-cell adhesion domain<br>This family is based on a group of Dictyostelium discoideum proteins that are essential in early development ( ). Swiss:P16642 and  Swiss:P16643 are located on the cell surface and mediate cell-cell adhesion.. 
+PF05721 Phytanoyl-CoA dioxygenase (PhyH)<br>Pfam-B_5670 (release 8.0). This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterised by the accumulation of phytanic acid in plasma and tissues  .. 
+PF05722 Ustilago B locus mating-type protein<br>Pfam-B_5804 (release 8.0). This family consists of several Ustilago mating-type proteins. The b locus of the phytopathogenic fungus Ustilago maydis encodes a multiallelic recognition function that controls the ability of the fungus to form a dikaryon and complete the sexual stage of the life cycle. The b locus has at least 25 alleles and any combination of two different alleles, brought together by mating between haploid cells, allows the fungus to cause disease and undergo sexual development within the plant  . . 
+PF05724 Thiopurine S-methyltransferase (TPMT)<br>Pfam-B_5821 (release 8.0). This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines  . . 
+PF05725 FNIP Repeat<br>This repeat is approximately 22 residues long and is only found in Dictyostelium discoideum. It appears to be related to Pfam:PF00560 (personal obs:C Yeats). The alignment consists of two tandem repeats. It is termed the FNIP repeat after the pattern of conserved residues.. 
+PF05726 Pirin C-terminal cupin domain<br>This region is found the C-terminal half of the Pirin protein.. 
+PF05727 Uncharacterised protein family (UPF0228)<br>
+PF05728 Uncharacterised protein family (UPF0227)<br>Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes that are distantly related to the Pfam:PF00561.. 
+PF05729 NACHT domain<br>This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation  . This family is closely related to Pfam:PF00931.. 
+PF05730 CFEM domain<br>This fungal specific cysteine rich domain is found in some proteins with proposed roles in fungal pathogenesis  .. 
+PF05731 TROVE domain<br>This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs.  This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding. . 
+PF05732 Firmicute plasmid replication protein (RepL)<br>Pfam-B_5929 (release 8.0). This family consists of Firmicute RepL proteins which are involved in plasmid replication.. 
+PF05733 Tenuivirus_N;<br>Tenuivirus/Phlebovirus nucleocapsid protein. Pfam-B_5998 (release 8.0) & Pfam-B_19756 (release 10.0). This family consists of several Tenuivirus and Phlebovirus nucleocapsid proteins [1,2]. These are ssRNA viruses.. 
+PF05734 Herpesvirus protein of unknown function (DUF832)<br>Pfam-B_7683 (release 8.0). This family consists of several herpesvirus proteins of unknown function.. 
+PF05735 TSPC;<br>Thrombospondin C-terminal region. Pfam-B_1875 (release 8.0). This region is found at the C-terminus of thrombospondin  and related proteins.. 
+PF05736 OprF_membrane; <br>OprF membrane domain. Pfam-B_4079 (release 8.0). This domain represents the presumed membrane spanning region of the OprF proteins. This region is involved in channel formation and is thought to form an 8-stranded beta-barrel  .. 
+PF05737 Collagen binding domain<br>Pfam-B_5000 (release 8.0). The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices  . A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.. 
+PF05738 Cna protein B-type domain<br>Pfam-B_366 (release 8.0). This domain is found in Staphylococcus aureus collagen-binding surface protein.  However, this region does not mediate collagen binding, the Pfam:PF05737 region carries out that function. The structure of the repetitive B-region has been solved   and forms a beta sandwich structure.  It is thought that this region forms a stalk in Staphylococcus aureus collagen-binding protein that presents the ligand binding domain away from the bacterial cell surface.. 
+PF05739 SNARE domain<br>Pfam-B_6285 (release 8.0). Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex  .. 
+PF05741 Nanos; <br>Nanos RNA binding domain. Pfam-B_5908 (release 8.0). This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localised determinant of posterior pattern. Nanos RNA is localised to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localised source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback  . Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded  very early in development. The localised and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development  . . 
+PF05742 DUF833;<br>Moxon SJ, Eberhardt R. Pfam-B_6481 (release 8.0). In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation  . In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit  . Swiss:P54797 has been found to be expressed during early embryogenesis in mice  . This protein contains a conserved NRDE motif.. 
+PF05743 Tsg101; <br>Pfam-B_6022 (release 8.0). This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer  . This family is related to the ubiquitin conjugating enzymes.. 
+PF05744 Benyvirus P25/P26 protein<br>Pfam-B_6153 (release 8.0). This family consists of P25 and P26 proteins from the beet necrotic yellow vein viruses.. 
+PF05745 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)<br>Pfam-B_6389 (release 8.0). This family consists of several Chlamydia 15 kDa cysteine-rich outer membrane proteins which are associated with differentiation of reticulate bodies (RBs) into elementary bodies (EBs)  .. 
+PF05746 tRNA-synt_1d_C; <br>DALR anticodon binding domain. Pfam-B_196 (release 8.0). This all alpha helical domain is the anticodon binding domain in Arginyl and glycyl tRNA synthetase. This domain is known as the DALR domain after characteristic  conserved amino acids  .. 
+PF05748 Rubella membrane glycoprotein E1<br>Pfam-B_6726 (release 8.0). Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus.  The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds  .. 
+PF05749 Rubella membrane glycoprotein E2<br>Pfam-B_6726 (release 8.0). Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus.  The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins  .. 
+PF05750 Rubella capsid protein<br>Pfam-B_6726 (release 8.0). Rubella virus is an enveloped positive-strand RNA virus of the family Togaviridae. Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly,  the capsid interacts with genomic RNA to form nucleocapsids. It has been discovered that capsid phosphorylation serves to negatively regulate binding of viral genomic RNA. This may delay the initiation of nucleocapsid assembly until sufficient amounts of virus glycoproteins accumulate at the budding site and/or prevent non-specific binding to cellular RNA when levels of genomic RNA are low. It follows that at a late stage in replication, the capsid may undergo dephosphorylation before nucleocapsid assembly occurs  .. 
+PF05751 FixH<br>Pfam-B_6803 (release 8.0). This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalysed by FixG  .. 
+PF05752 Calicivirus_MSP; <br>Calicivirus minor structural protein. Pfam-B_6811 (release 8.0). This family consists of minor structural proteins largely from human calicivirus isolates. Human calicivirus causes gastroenteritis  . The function of this family is unknown.. 
+PF05753 Translocon-associated protein beta (TRAPB)<br>Pfam-B_6857 (release 8.0). This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion  .. 
+PF05754 Domain of unknown function (DUF834)<br>Pfam-B_9258 (release 8.0). This short presumed domain is found in a large number of hypothetical plant proteins. The domain is quite rich in conserved glycine residues.\.  It occurs in some putative transposons but currently has no known function.. 
+PF05755 Rubber elongation factor protein (REF)<br>Pfam-B_6903 (release 8.0). This family consists of the highly related rubber elongation factor (REF), small rubber particle protein (SRPP) and stress-related protein (SRP) sequences. REF and SRPP are released from the rubber particle membrane into the cytosol during osmotic lysis of the sedimentable organelles (lutoids). The exact function of this family is unknown  . . 
+PF05756 S-antigen protein<br>Pfam-B_7194 (release 8.0). S-antigens are heat stable proteins that are found in the blood of individuals infected with malaria  .. 
+PF05757 Oxygen evolving enhancer protein 3 (PsbQ)<br>Pfam-B_6905 (release 8.0). This family consists of the plant specific oxygen evolving enhancer protein 3 (PsbQ). Photosystem II (PSII)1 is a pigment-protein complex, which consists of at least 25 different protein subunits, at present denoted PsbA-Z according to the genes that encode them. PsbQ plays an important role in the lumenal oxygen-evolving activity of PSII from higher plants and green algae  . . 
+PF05758 Ycf1<br>Pfam-B_6040 (release 8.0). The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. Although the function of Ycf1 is unknown, it is known to be an essential gene  .. 
+PF05760 Immediate early response protein (IER)<br>Pfam-B_6450 (release 8.0). This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it  play an important role in mediating the cellular response to mitogenic signals [1,2]. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals [3,4].. 
+PF05761 5_nucleotidase; <br>5' nucleotidase family. Pfam-B_2948 (release 8.0). This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.. 
+PF05762 vwa_CoxE; <br>VWA domain containing CoxE-like protein. Pfam-B_2956 (release 8.0). This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain.  The exact function of this family is unknown.  It is found as part of a CO oxidising (Cox) system operon is several bacteria  .. 
+PF05763 Protein of unknown function (DUF835)<br>Pfam-B_3039 (release 8.0). The members of this archaebacterial protein family are around 250-300 amino acid residues in length. The function of these proteins is not known.. 
+PF05764 YL1 nuclear protein<br>Pfam-B_3088 (release 8.0). The proteins in this family are designated YL1  . These proteins have been shown to be DNA-binding and may be a transcription factor  .. 
+PF05766 Bacteriophage Lambda NinG protein<br>Pfam-B_7000 (release 8.0). NinG or Rap is involved in recombination. Rap (recombination adept with plasmid) increases lambda-by-plasmid recombination catalysed by Escherichia coli's RecBCD pathway  .. 
+PF05767 Poxvirus virion envelope protein A14<br>Pfam-B_7009 (release 8.0). This family consists of several Poxvirus virion envelope protein A14 like sequences. A14 is a component of the virion membrane and has been found to be an H1 phosphatase substrate in vivo and in vitro. A14 is hyperphosphorylated on serine residues in the absence of H1 expression  .. 
+PF05768 Glutaredoxin-like domain (DUF836)<br>Pfam-B_7010 (release 8.0) & Pfam-B_2829 (release 14.0). These proteins are related to the Pfam:PF00462 family.. 
+PF05769 Protein of unknown function (DUF837)<br>Pfam-B_7035 (release 8.0). This family consists of several eukaryotic proteins of unknown function. One of the family members (Swiss:O02197) is a circulating cathodic antigen (CCA) found in Schistosoma mansoni (Blood fluke)  .. 
+PF05770 Inositol 1, 3, 4-trisphosphate 5/6-kinase<br>Pfam-B_7042 (release 8.0). This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase  .. 
+PF05771 Poxvirus A31 protein<br>Pfam-B_7044 (release 8.0). 
+PF05772 NinB protein<br>Pfam-B_4884 (release 8.0). The ninR region of phage lambda contains two recombination genes, orf (ninB) and rap (ninG), that have roles when the RecF and RecBCD recombination pathways of E. coli, respectively, operate on phage lambda.. 
+PF05773 RWD domain<br>Pfam-B_3991 (release 8.0). This domain was identified in WD40 repeat proteins and Ring finger domain proteins  . The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain   after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices  .. 
+PF05774 Herpesvirus helicase-primase complex component<br>Pfam-B_7045 (release 8.0). This family consists of several helicase-primase complex components from the Gammaherpesviruses.. 
+PF05775 Enterobacteria AfaD invasin protein<br>Pfam-B_7107 (release 8.0). This family consists of several AfaD and related proteins from Escherichia coli and Salmonella bacteria. The afa gene clusters encode an afimbrial adhesive sheath produced by Escherichia coli. The adhesive sheath is composed of two proteins, AfaD and AfaE, which are independently exposed at the bacterial cell surface.  AfaE is required for bacterial adhesion to HeLa cells and AfaD for the uptake of adherent bacteria into these cells  . . 
+PF05776 Papillomavirus E5A protein<br>Pfam-B_7244 (release 8.0). Human papillomaviruses (HPVs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. The kinetics of E5a protein expression during the complete viral life cycle has been studied and the highest level was found to be coincidental with the onset of virion morphogenesis  . . 
+PF05777 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)<br>Pfam-B_7275 (release 8.0). This family consists of accessory gland-specific 26Ab peptides or male accessory gland secretory protein 355B from different Drosophila species. Drosophila males, like males of most other insects, transfer a group of specific proteins (Acp26Ab and Acp26Aa in Drosophila) to the females during mating. These proteins are produced primarily in the accessory gland and are likely to influence the female's reproduction  . . 
+PF05778 Apolipoprotein CIII (Apo-CIII)<br>Pfam-B_7283 (release 8.0). This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesised in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma  .. 
+PF05781 MRVI1 protein<br>Pfam-B_7407 (release 8.0). This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumour suppressor gene  . IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP  . Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins  .. 
+PF05782 Extracellular matrix protein 1 (ECM1)<br>Pfam-B_7421 (release 8.0). This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis [1,2]. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness  .. 
+PF05783 Dynein light intermediate chain (DLIC)<br>Pfam-B_7447 (release 8.0). This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin [1,2]. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo  . . 
+PF05784 Betaherpesvirus UL82/83 protein N terminus<br>Pfam-B_7466 (release 8.0). This family represents the N terminal region of the Betaherpesvirus UL82 and UL83 proteins. As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. Human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they enter the S phase, a cell cycle compartment that is presumably favourable for viral replication. The protein product of the human cytomegalovirus UL82 gene, pp71, can accelerate the movement of cells through the G(1) phase of the cell cycle. This activity would help infected cells reach the late G(1) arrest point sooner and thus may stimulate the infectious cycle. pp71 also induces DNA synthesis in quiescent cells, but a pp71 mutant protein that is unable to induce quiescent cells to enter the cell cycle still retains the ability to accelerate the G(1) phase. Thus, the mechanism through which pp71 accelerates G(1) cell cycle progression appears to be distinct from the one that it employs to induce quiescent cells to exit G(0) and subsequently enter the S phase  . . 
+PF05785 Rho-activating domain of cytotoxic necrotizing factor<br>Pfam-B_7489 (release 8.0). This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells  . Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain  .. 
+PF05786 Barren;<br>Condensin complex subunit 2. Pfam-B_7477 (release 8.0). This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons.  Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localises to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase  . This family forms one of the three non-structural maintenance of chromosomes (SMC) subunits of the mitotic condensation complex along with Cnd1 and Cnd3  .. 
+PF05787 Bacterial protein of unknown function (DUF839)<br>Pfam-B_7480 (release 8.0). This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.. 
+PF05788 Orbivirus_VP1; <br>Orbivirus RNA-dependent RNA polymerase (VP1). Pfam-B_7493 (release 8.0). This family consists of the RNA-dependent RNA polymerase protein VP1 from the Orbiviruses. VP1 may have both enzymatic and structural roles in the virus life cycle  .. 
+PF05789 Baculovirus VP1054 protein<br>Pfam-B_7511 (release 8.0). This family consists of several VP1054 proteins from the Baculoviruses. VP1054 is a virus structural protein required for nucleocapsid assembly  . . 
+PF05790 CD2;<br>Immunoglobulin C2-set domain. 
+PF05791 Bacillus haemolytic enterotoxin (HBL)<br>Pfam-B_7539 (release 8.0). This family consists of several Bacillus haemolytic enterotoxins (HblC, HblD, HblA, NheA, and NheB) which can cause food poisoning in humans  .. 
+PF05792 Candida agglutinin-like (ALS)<br>Pfam-B_7578 (release 8.0). This family consists of several agglutinin-like proteins from different Candida species. ALS genes of Candida albicans encode a family of cell-surface glycoproteins with a three-domain structure. Each Als protein has a relatively conserved N-terminal domain, a central domain consisting of a tandemly repeated motif of variable number, and a serine-threonine-rich C-terminal domain that is relatively variable across the family. The ALS family exhibits several types of variability that indicate the importance of considering strain and allelic differences when studying ALS genes and their encoded proteins  . Fungal adhesins, which include sexual agglutinins, virulence factors, and flocculins, are surface proteins that mediate cell-cell and cell-environment interactions. It is possible that both the serine/threonine-rich domain and the cysteine residues in the C-terminal and DIPSY Pfam:PF11763 participate in anchoring the terminal domains inside the wall, so that only the inner part of Map4p, including the repeat region, is sticking out as a fold-back loop then able to act in adhesing  .. 
+PF05793 TFIIF-alpha; <br>Transcription initiation factor IIF, alpha subunit (TFIIF-alpha). Pfam-B_7586 (release 8.0). Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II  .. 
+PF05794 T-complex protein 11<br>Pfam-B_7604 (release 8.0). This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility [1,2,3]. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants  .. 
+PF05795 Plasmodium vivax Vir protein<br>Pfam-B_7631 (release 8.0). This family consists of several Vir proteins specific to Plasmodium vivax. The vir genes are present at about 600-1,000 copies per haploid genome and encode proteins that are immunovariant in natural infections, indicating that they may have a functional role in establishing chronic infection through antigenic variation  . . 
+PF05796 Chordopoxvirus protein G2<br>Pfam-B_7672 (release 8.0). This family consists of several Chordopoxvirus isatin-beta-thiosemicarbazone dependent protein (protein G2) sequences. Inactivation of the gene coding for this protein renders the virus dependent upon isatin-beta-thiosemicarbazone (IBT) for growth  .. 
+PF05797 Yeast_TAF; <br>Yeast trans-acting factor (REP1/REP2). Pfam-B_7680 (release 8.0). This family consists of the yeast trans-acting factor B and C (REP1 and 2) proteins. The yeast plasmid stability system consists of two plasmid-coded proteins, Rep1 and Rep2, and a cis-acting locus, STB. The Rep proteins show both self- and cross-interactions in vivo and in vitro, and bind to the STB DNA with assistance from host factor(s). Within the yeast nucleus, the Rep1 and Rep2 proteins tightly associate with STB-containing plasmids into well organised plasmid foci that form a cohesive unit in partitioning. It is generally accepted that the protein-protein and DNA-protein interactions engendered by the Rep-STB system are central to plasmid partitioning. Point mutations in Rep1 that knock out interaction with Rep2 or with STB simultaneously block the ability of these Rep1 variants to support plasmid stability  .. 
+PF05798 Bacteriophage FRD3 protein<br>Pfam-B_7781 (release 8.0). This family consists of bacteriophage FRD3 proteins.. 
+PF05800 Gas vesicle synthesis protein GvpO<br>Pfam-B_8221 (release 8.0). This family consists of archaeal GvpO proteins which are required for gas vesicle synthesis  . The family also contains two related sequences from Streptomyces coelicolor. . 
+PF05801 Lagovirus protein of unknown function (DUF840)<br>Pfam-B_8265 (release 8.0). This family consists of several Lagovirus sequences of unknown function, largely from rabbit hemorrhagic disease virus.. 
+PF05802 Enterobacterial EspB protein<br>Pfam-B_8424 (release 8.0). EspB is a type-III-secreted pore-forming protein of enteropathogenic Escherichia coli (EPEC) which is essential for EPEC pathogenesis  . EspB is also found in Citrobacter rodentium  .. 
+PF05803 Chordopoxvirus L2 protein<br>Pfam-B_8620 (release 8.0). This family consists of several Chordopoxvirus L2 proteins.. 
+PF05804 Kinesin-associated protein (KAP)<br>Pfam-B_8674 (release 8.0). This family consists of several eukaryotic kinesin-associated (KAP) proteins. Kinesins are intracellular multimeric transport motor proteins that move cellular cargo on microtubule tracks. It has been shown that the sea urchin KRP85/95 holoenzyme associates with a KAP115 non-motor protein, forming a heterotrimeric complex in vitro, called the Kinesin-II  .  . 
+PF05805 L6 membrane protein<br>Pfam-B_7771 (release 8.0). This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family  . Several members of this family have been implicated in human cancer [2,3].. 
+PF05806 Noggin<br>Pfam-B_7925 (release 8.0). This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation  .. 
+PF05808 Podoplanin<br>Pfam-B_8548 (release 8.0). This family consists of several mammalian podoplanin like proteins which are thought to control specifically the unique shape of podocytes  .. 
+PF05810 NinF protein<br>Pfam-B_8528 (release 8.0). This family consists of several bacteriophage NinF proteins as well as related sequences from E. coli.. 
+PF05811 Eukaryotic protein of unknown function (DUF842)<br>Pfam-B_7096 (release 8.0). This family consists of a number of conserved eukaryotic proteins of unknown function. The sequences carry three sets of CxxxC motifs, which might suggest a type of zinc-finger formation.. 
+PF05812 Herpesvirus BLRF2 protein<br>Pfam-B_7251 (release 8.0). This family consists of several Herpesvirus BLRF2 proteins.. 
+PF05813 Orthopoxvirus F7 protein<br>Pfam-B_7318 (release 8.0). 
+PF05814 Baculovirus protein of unknown function (DUF843)<br>Pfam-B_7353 (release 8.0). This family consists of several Baculovirus proteins of around 85 residues long with no known function.. 
+PF05815 Baculovirus protein of unknown function (DUF844)<br>Pfam-B_7453 (release 8.0). This family consists of several Baculovirus sequences of between 350 and 380 residues long. The family has no known function.. 
+PF05816 Toxic anion resistance protein (TelA)<br>Pfam-B_7534 (release 8.0). This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance   and plasmid fertility inhibition  .. 
+PF05817 Oligosaccharyltransferase subunit Ribophorin II<br>Pfam-B_7633 (release 8.0). This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesised polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them   .. 
+PF05818 Enterobacterial TraT complement resistance protein<br>Pfam-B_7686 (release 8.0). The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between an Escherichia coli and its surroundings [1,2].. 
+PF05819 NolX protein<br>Pfam-B_7801 (release 8.0). This family consists of Rhizobium NolX and Xanthomonas HrpF proteins. The interaction between the plant pathogen Xanthomonas campestris pv. vesicatoria and its host plants is controlled by hrp genes (hypersensitive reaction and pathogenicity), which encode a type III protein secretion system. Among type III-secreted proteins are avirulence proteins, effectors involved in the induction of plant defence reactions. HrpF is dispensable for protein secretion but required for AvrBs3 recognition in planta, is thought to function as a translocator of effector proteins into the host cell  . NolX, a soybean cultivar specificity protein, is secreted by a type III secretion system (TTSS) and shows homology to HrpF of the plant pathogen Xanthomonas campestris pv. vesicatoria. It is not known whether NolX functions at the bacterium-plant interface or acts inside the host cell. NolX is expressed in planta only during the early stages of nodule development  .. 
+PF05820 Baculovirus protein of unknown function (DUF845)<br>Pfam-B_7739 (release 8.0). This family consists of several highly related Baculovirus proteins of unknown function.. 
+PF05821 NDUFB8; <br>NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8). Pfam-B_7830 (release 8.0). This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits  .. 
+PF05822 Pyrimidine 5'-nucleotidase (UMPH-1)<br>Pfam-B_7840 (release 8.0). This family consists of several eukaryotic pyrimidine 5'-nucleotidase proteins. P5'N-1, also known as uridine monophosphate hydrolase-1 (UMPH-1), is a member of a large functional group of enzymes, characterised by the ability to dephosphorylate nucleic acids. P5'N-1 catalyses the dephosphorylation of pyrimidine nucleoside monophosphates to the corresponding nucleosides. Deficiencies in this proteins function can lead to several different disorders in humans  .. 
+PF05823 Nematode fatty acid retinoid binding protein (Gp-FAR-1)<br>Pfam-B_7852 (release 8.0). Parasitic nematodes produce at least two structurally novel classes of small helix-rich retinol- and fatty-acid-binding proteins that have no counterparts in their plant or animal hosts and thus represent potential targets for new nematicides. Gp-FAR-1 is a member of the nematode-specific fatty-acid- and retinol-binding (FAR) family of proteins but localises to the surface of the organism, placing it in a strategic position for interaction with the host. Gp-FAR-1 functions as a broad-spectrum retinol- and fatty-acid-binding protein, and it is thought that it is involved in the evasion of primary host plant defence systems  .. 
+PF05824 Pro-melanin-concentrating hormone (Pro-MCH)<br>Pfam-B_7863 (release 8.0). This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone  .. 
+PF05825 Beta-microseminoprotein (PSP-94)<br>Pfam-B_7865 (release 8.0). This family consists of the mammalian specific protein beta-microseminoprotein. Prostatic secretory protein of 94 amino acids (PSP94), also called beta-microseminoprotein, is a small, nonglycosylated protein, rich in cysteine residues. It was first isolated as a major protein from human seminal plasma  . The exact function of this protein is unknown.. 
+PF05826 Phospholip_A2; <br>Pfam-B_7918 (release 8.0). This family consists of several phospholipase A2 like proteins mostly from insects  .. 
+PF05827 Vacuolar ATP synthase subunit S1 (ATP6S1)<br>Pfam-B_8145 (release 8.0). This family consists of eukaryotic vacuolar ATP synthase subunit S1 proteins  . It also contains BIG1 ER integral membrane proteins which are involved in cell wall organisation and biogenesis  .. 
+PF05829 Adenovirus_PX; <br>Adenovirus late L2 mu core protein (Protein X). Pfam-B_8179 (release 8.0). This family consists of several Adenovirus late L2 mu core protein or Protein X sequences.. 
+PF05830 Nodulation protein Z (NodZ)<br>Pfam-B_8202 (release 8.0). The nodulation genes of Rhizobia are regulated by the nodD gene product in response to host-produced flavonoids and appear to encode enzymes involved in the production of a lipo-chitose signal molecule required for infection and nodule formation. NodZ is required for the addition of a 2-O-methylfucose residue to the terminal reducing N-acetylglucosamine of the nodulation signal. This substitution is essential for the biological activity of this molecule. Mutations in nodZ result in defective nodulation. nodZ represents a unique nodulation gene that is not under the control of NodD and yet is essential for the synthesis of an active nodulation signal  . . 
+PF05831 GAGE protein<br>Pfam-B_8207 (release 8.0). This family consists of several GAGE and XAGE proteins which are found exclusively in humans. The function of this family is unknown although they have been implicated in human cancers  .. 
+PF05832 Eukaryotic protein of unknown function (DUF846)<br>Pfam-B_8404 (release 8.0). This family consists of several of unknown function from a variety of eukaryotic organisms.. 
+PF05833 Fibronectin-binding protein A N-terminus (FbpA)<br>Pfam-B_8577 (release 8.0). This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host  . . 
+PF05834 Lycopene cyclase protein<br>Pfam-B_8336 (release 8.0). This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclisation of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare [1,2].  . 
+PF05835 Synaphin protein<br>Pfam-B_8588 (release 8.0). This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles  . Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin  transmembrane regions that reside in opposing membranes prior to fusion  .. 
+PF05836 Chorion protein S16<br>Pfam-B_8659 (release 8.0). This family consists of several examples of the fruit fly specific chorion protein S16.  The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary  . . 
+PF05837 Centromere protein H (CENP-H)<br>Pfam-B_8705 (release 8.0). This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localised in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle  . This the C-terminus of the region, which is conserved from fungi to humans.. 
+PF05838 DUF847;<br>Glycosyl hydrolase 108. Pfam-B_8737 (release 8.0). This family acts as a lysozyme (N-acetylmuramidase), EC:3.2.1.17. It contains a conserved EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity  . In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion [2,3]. It is frequently found at the N-terminus of proteins containing a C-terminal Pfam:PF09374 domain.. 
+PF05839 Apc13p protein<br>The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators Members of this family are components of the anaphase-promoting complex homologous to Apc13p  .. 
+PF05840 Bacteriophage replication gene A protein (GPA)<br>Pfam-B_8738 (release 8.0). This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases [1,2,3].. 
+PF05841 Apc15p protein<br>The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators Members of this family are components of the anaphase-promoting complex homologous to Apc15p Swiss:O94688  .. 
+PF05842 Euplotes octocarinatus mating pheromone protein<br>Pfam-B_8825 (release 8.0). This family consists of several mating pheromone proteins from Euplotes octocarinatus. Cells of the ten mating types of the ciliate Euplotes octocarinatus communicate by pheromones before they enter conjugation. The pheromones induce homotypic pairing when applied to mating types that do not secrete the same pheromone(s). Heterotypic pairs (i.e., those between cells of different mating types) are formed only when both mating types in a mixture secrete a pheromone that the other does not. The genetics of mating types is based on four codominant mating type alleles, each allele determining production of a different pheromone. The pheromones not only induce pair formation but also attract cells  .. 
+PF05843 Suppressor of forked protein (Suf)<br>Pfam-B_8911 (release 8.0). This family consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster Suppressor of forked [Su(f)] protein shares homology with the yeast RNA14 protein and the 77-kDa subunit of human cleavage stimulation factor, which are proteins involved in mRNA 3' end formation. This suggests a role for Su(f) in mRNA 3' end formation in Drosophila. The su(f) gene produces three transcripts; two of them are polyadenylated at the end of the transcription unit, and one is a truncated transcript, polyadenylated in intron 4. It is thought that su(f) plays a role in the regulation of poly(A) site utilisation and an important role of the GU-rich sequence for this regulation to occur  .. 
+PF05844 YopD protein<br>Pfam-B_8937 (release 8.0). This family consists of several bacterial YopD like proteins. Virulent Yersinia species harbour a common plasmid that encodes essential virulence determinants (Yersinia outer proteins [Yops]), which are regulated by the extracellular stimuli Ca2+ and temperature. YopD is thought to be a possible transmembrane protein and contains an amphipathic alpha-helix in its carboxy terminus  .  . 
+PF05845 Bacterial phosphonate metabolism protein (PhnH)<br>Pfam-B_9057 (release 8.0). This family consists of several bacterial PhnH sequences which are known to be involved in phosphonate metabolism [1,2].. 
+PF05846 Chordopoxvirus A15 protein<br>Pfam-B_9149 (release 8.0). This family consists of several Chordopoxvirus A15 like sequences.. 
+PF05847 Nucleopolyhedrovirus late expression factor 3 (LEF-3)<br>Moxon SJ, Mistry J, Carstens EB. Pfam-B_9292 (release 8.0). This family consists of LEF-3 Nucleopolyhedrovirus late expression factor 3 (LEF-3) sequences which are known to be ssDNA-binding proteins  .  Alkaline nuclease (AN) and LEF-3 may participate in homologous recombination of the baculovirus genome in a manner similar to that of exonuclease (Redalpha) and DNA-binding protein (Redbeta) of the Red-mediated homologous recombination system of bacteriophage lambda  .\.       LEF-3 is essential for transporting the putative baculovirus helicase protein P143 into the nucleus where they function together during viral DNA replication  . LEF-3 and other proteins have been shown to bind to closely linked sites on viral chromatin in vivo, suggesting that they may form part of the baculovirus replisome  .. 
+PF05848 Firmicute transcriptional repressor of class III stress genes (CtsR)<br>Pfam-B_9312 (release 8.0). This family consists of several Firmicute transcriptional repressor of class III stress genes (CtsR) proteins. CtsR of L. monocytogenes negatively regulates the clpC, clpP and clpE genes belonging to the CtsR regulon  .. 
+PF05849 Fibroin light chain (L-fibroin)<br>Pfam-B_9321 (release 8.0). This family consists of several moth fibroin light chain (L-fibroin) proteins. Fibroin of the silkworm, Bombyx mori, is secreted into the lumen of posterior silk gland (PSG) from the surrounding PSG cells as a molecular complex consisting of a heavy (H)-chain of approximately 350 kDa, a light (L)-chain of 25 kDa and a P25 of about 27 kDa. The H- and L-chains are disulfide-linked but P25 is associated with the H-L complex by non-covalent force  .. 
+PF05851 Lentivirus virion infectivity factor (VIF)<br>Pfam-B_9439 (release 8.0). This family consists of several feline specific Lentivirus virion infectivity factor (VIF) proteins. VIF is essential for productive FIV infection of host target cells in vitro  .. 
+PF05852 Gammaherpesvirus protein of unknown function (DUF848)<br>Pfam-B_9475 (release 8.0). This family consists of several uncharacterised proteins from the Gammaherpesvirinae.. 
+PF05853 Prokaryotic protein of unknown function (DUF849)<br>Pfam-B_9059 (release 8.0). This family consists of several hypothetical prokaryotic proteins with no known function.. 
+PF05854 Non-histone chromosomal protein MC1<br>Pfam-B_9146 (release 8.0). This family consists of archaeal chromosomal protein MC1 sequences which protect DNA against thermal denaturation  . . 
+PF05856 ARP2/3 complex 20 kDa subunit (ARPC4)<br>Pfam-B_9272 (release 8.0). This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion  .. 
+PF05857 TraX protein<br>Pfam-B_9375 (release 8.0). This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits [1,2].. 
+PF05858 Bovine immunodeficiency virus surface protein (SU)<br>Pfam-B_9413 (release 8.0). The bovine lentivirus also known as the bovine immunodeficiency-like virus (BIV) has conserved and hypervariable regions in the surface envelope gene  . This family corresponds to the SU surface protein.. 
+PF05859 Mis12 protein<br>Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length  . Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants  . It has been shown that Mis12  genetically interacts with Mal2, another inner centromere core  complex protein in S. pombe  .. 
+PF05860 haemagglutination activity domain<br>This domain is suggested to be a carbohydrate- dependent haemagglutination activity site ( ). It is found in a range of haemagglutinins and  haemolysins.. 
+PF05861 Bacterial phosphonate metabolism protein (PhnI)<br>Pfam-B_9004 (release 8.0). This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organised in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex  .. 
+PF05862 Helicobacter pylori IceA2 protein<br>Pfam-B_9436 (release 8.0). This family consists of several Helicobacter pylori specific IceA2 proteins. The function of this family is unknown.. 
+PF05864 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)<br>Pfam-B_9596 (release 8.0). This family consists of several Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide sequences. DNA-dependent RNA polymerase catalyses the transcription of DNA into RNA.. 
+PF05865 Cypovirus polyhedrin protein<br>Pfam-B_9652 (release 8.0). This family consists of several Cypovirus polyhedrin protein. Polyhedrin is known to form a crystalline matrix (polyhedra) in infected insect cells  .. 
+PF05866 Endodeoxyribonuclease RusA<br>Pfam-B_8996 (release 8.0). This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC [1,2].. 
+PF05867 Protein of unknown function (DUF851)<br>Pfam-B_9669 (release 8.0), Jackhmmer:Q9N4S5. 
+PF05868 Rotavirus major outer capsid protein VP7<br>Pfam-B_9690 (release 8.0). This family consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer  .. 
+PF05869 DNA N-6-adenine-methyltransferase (Dam)<br>Pfam-B_9691 (release 8.0). This family consists of several bacterial and phage DNA N-6-adenine-methyltransferase (Dam) like sequences  .. 
+PF05870 Phenolic acid decarboxylase (PAD)<br>Pfam-B_9737 (release 8.0). This family consists of several bacterial phenolic acid decarboxylase proteins. Phenolic acids, also called substituted cinnamic acids, are important lignin-related aromatic acids and natural constituents of plant cell walls. These acids (particularly ferulic, p-coumaric, and caffeic acids) bind the complex lignin polymer to the hemicellulose and cellulose in plants. The Phenolic acid decarboxylase (PAD) gene (pad) is transcriptionally regulated by p-coumaric, ferulic, or caffeic acid; these three acids are the three substrates of PAD  .. 
+PF05871 DUF852; <br>ESCRT-II complex subunit. Moxon SJ, Wood V, Mistry J. Pfam-B_9765 (release 8.0). This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB)  .  This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo  .. 
+PF05872 Bacterial protein of unknown function (DUF853)<br>Pfam-B_9798 (release 8.0). This family consists of several bacterial proteins of unknown function. Swiss:Q8YFZ2 is thought to be an ATPase.. 
+PF05873 ATP synthase D chain, mitochondrial (ATP5H)<br>Pfam-B_9814 (release 8.0). This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts [1,2]. . 
+PF05874 Pheromone biosynthesis activating neuropeptide (PBAN)<br>Pfam-B_9874 (release 8.0). This family consists of several moth pheromone biosynthesis activating neuropeptide (PBAN) sequences. Female moths produce and release species specific sex pheromones to attract males for mating. Pheromone biosynthesis is hormonally regulated by the Pheromone Biosynthesis Activating Neuropeptide (PBAN) which is biosynthesised in the subesophageal ganglion (SOG)  .  . 
+PF05875 aPHC;<br>Pfam-B_9877 (release 8.0). This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.. 
+PF05876 Phage terminase large subunit (GpA)<br>Pfam-B_9892 (release 8.0). This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities  . . 
+PF05878 Phytoreovirus nonstructural protein Pns9/Pns10<br>Pfam-B_9947 (release 8.0). This family consists of the Phytoreovirus nonstructural proteins Pns9 and Pns10. The function of this family is unknown.. 
+PF05879 Root hair defective 3 GTP-binding protein (RHD3)<br>Pfam-B_9973 (release 8.0). This family consists of several eukaryotic root hair defective 3 like GTP-binding proteins. It has been speculated that the RHD3 protein is a member of a novel class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement  . The family also contains the homologous yeast synthetic enhancement of YOP1 (SEY1) protein which is involved in membrane trafficking  .. 
+PF05880 Fijivirus 64 kDa capsid protein<br>Pfam-B_9976 (release 8.0). This family consists of several Fijivirus 64 kDa capsid proteins.. 
+PF05881 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)<br>Moxon SJ, Mazumder R. Pfam-B_9997 (release 8.0). This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity  . CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins  .. 
+PF05883 DUF855; <br>Baculovirus U-box/Ring-like domain. Pfam-B_9633 (release 8.0). This family consists of several Baculovirus proteins of around 130 residues in length. The function of this family is unknown, but it appears to be related to the U-box and ring finger domain by profile-profile comparison.. 
+PF05884 DUF856;<br>Interactor of ZYG-11. Pfam-B_9445 (release 8.0). This family of proteins represents the protein product of the gene W03D8.9 which has been identified as an interactor of ZYG-11.  ZYG-11 is the substrate-recognition subunit for a CUL-2 based complex that regulates cell division and embryonic development  .. 
+PF05886 Orthopoxvirus F8 protein<br>Pfam-B_9539 (release 8.0). This family consists of several Orthopoxvirus F8 proteins. The function of this family is unknown.. 
+PF05887 Trypano_PARP; <br>Procyclic acidic repetitive protein (PARP). Pfam-B_9554 (release 8.0). This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated  .  . 
+PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)<br>Pfam-B_9614 (release 8.0). This family consists of several eukaryotic and archaeal proteins which are related to the human soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen). Autoantibodies are a hallmark of autoimmune hepatitis, but most are not disease specific. Autoantibodies to soluble liver antigen (SLA) and to liver and pancreas antigen (LP) have been described as disease specific, occurring in about 30% of all patients with autoimmune hepatitis  . The function of SLA/LP is unknown, however, it has been suggested that the protein may function as a serine hydroxymethyltransferase and may be an important enzyme in the thus far poorly understood selenocysteine pathway  . The archaeal sequences Swiss:Q8TXK0 and Swiss:Q8TYR3 are annotated as being pyridoxal phosphate-dependent enzymes.. 
+PF05890 Eukaryotic rRNA processing protein EBP2<br>Moxon SJ, Mistry J, Wood V. Pfam-B_9615 (release 8.0). This family consists of several Eukaryotic rRNA processing protein EBP2 sequences.  Ebp2p is required for the maturation of 25S rRNA and 60S subunit assembly. Ebp2p may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis  .  This family also plays a role in chromosome segregation  .. 
+PF05891 DUF858; Hydroxy-O-Methy;<br>AdoMet dependent proline di-methyltransferase. Pfam-B_9735 (release 8.0). This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyses the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognise the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified  . As with other methyltransferases, this family carries the characteristic GxGxG motif.. 
+PF05892 Trichovirus coat protein<br>Pfam-B_9763 (release 8.0). This family consists of several coat proteins which are specific to the ssRNA positive-strand, no DNA stage viruses such as the Trichovirus and Vitivirus.. 
+PF05893 Acyl-CoA reductase (LuxC)<br>Pfam-B_9766 (release 8.0). This family consists of several bacterial Acyl-CoA reductase (LuxC) proteins. The channelling of fatty acids into the fatty aldehyde substrate for the bacterial bioluminescence reaction is catalysed by a fatty acid reductase multienzyme complex, which channels fatty acids through the thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components  .. 
+PF05894 Podovirus DNA encapsidation protein (Gp16)<br>Pfam-B_9825 (release 8.0). This family consists of several DNA encapsidation protein (Gp16) sequences from the phi-29-like viruses. Gene product 16 catalyses the in vivo and in vitro genome-encapsidation reaction  . . 
+PF05895 Siphovirus protein of unknown function (DUF859)<br>Pfam-B_9891 (release 8.0). This family consists of several uncharacterised proteins from the Siphoviruses as well as one bacterial sequence Swiss:Q8K6J6. Some of the members of this family are described as putative minor structural proteins.. 
+PF05896 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)<br>Pfam-B_3622 (release 8.0). This family consists of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins. The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration  .. 
+PF05899 DUF861; <br>Protein of unknown function (DUF861). Pfam-B_2000 (release 8.0). This family consists of several proteins which seem to be specific to plants and bacteria. The function of this family is unknown.. 
+PF05901 Excalibur calcium-binding domain<br>Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognised and the evolution of EF-hand-like domains is probably more complex than previously appreciated  .. 
+PF05902 4.1 protein C-terminal domain (CTD)<br>At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although  such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates  . . 
+PF05903 DUF862;<br>PPPDE putative peptidase domain. The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p)  .. 
+PF05904 Plant protein of unknown function (DUF863)<br>Pfam-B_7732 (release 8.0). This family consists of a number of hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.. 
+PF05906 Herpesvirus-7 repeat of unknown function (DUF865)<br>Pfam-B_9911 (release 8.0). This family consists of a series of 12 repeats of 35 amino acids in length which are found exclusively in Herpesvirus-7. The function of this family is unknown.. 
+PF05907 Eukaryotic protein of unknown function (DUF866)<br>Pfam-B_8299 (release 8.0). This family consists of a number of hypothetical eukaryotic proteins of unknown function with an average length of around 165 residues.. 
+PF05908 Protein of unknown function (DUF867)<br>Pfam-B_7778 (release 8.0). This family consists of a number of bacterial and phage proteins with no known function and is present in Bacillus species and the Lambda-like viruses.. 
+PF05910 Plant protein of unknown function (DUF868)<br>Pfam-B_8013 (release 8.0). This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.. 
+PF05911 Plant protein of unknown function (DUF869)<br>Pfam-B_8094 (release 8.0). This family consists of a number of sequences found in Arabidopsis thaliana, Oryza sativa and Lycopersicon esculentum (Tomato). The function of this family is unknown.  . 
+PF05912 Caenorhabditis elegans protein of unknown function (DUF870)<br>Pfam-B_8400 (release 8.0). This family consists of a number of hypothetical proteins which seem to be specific to Caenorhabditis elegans. The function of this family is unknown.. 
+PF05913 Bacterial protein of unknown function (DUF871)<br>Pfam-B_8510 (release 8.0). This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.. 
+PF05914 RIB43A<br>Pfam-B_8571 (release 8.0). This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialised set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterised in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialised protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organising their three-dimensional structure. Human RIB43A homologues could represent a structural requirement in centriole replication in dividing cells  .. 
+PF05915 Eukaryotic protein of unknown function (DUF872)<br>Pfam-B_8741 (release 8.0). This family consists of several uncharacterised eukaryotic proteins. The function of this family is unknown.. 
+PF05916 DUF873; <br>GINS complex protein. Pfam-B_8759 (release 8.0). The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3].  It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family.  The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase  .. 
+PF05917 Helicobacter pylori protein of unknown function (DUF874)<br>Pfam-B_8835 (release 8.0). This family consists of several hypothetical proteins specific to Helicobacter pylori. The function of this family is unknown.. 
+PF05918 Apoptosis inhibitory protein 5 (API5)<br>Pfam-B_8916 (release 8.0). This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterised by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors [1,2].. 
+PF05919 Mitovirus RNA-dependent RNA polymerase<br>Pfam-B_9906 (release 8.0). This family consists of several Mitovirus RNA-dependent RNA polymerase proteins. The family also contains fragment matches in the mitochondria of Arabidopsis thaliana.. 
+PF05920 Coprinus_mating;<br>Pfam-B_4610 (release 8.0). This is a homeobox transcription factor KN domain conserved from fungi to human and plants.. 
+PF05922 Subtilisin_N; <br>Peptidase inhibitor I9. Pfam-B_52 (release 8.0). This family includes the proteinase B inhibitor from Saccharomyces cerevisiae and the activation peptides from peptidases of the subtilisin family.  The subtilisin propeptides are known to function as molecular chaperones, assisting in the folding of the mature peptidase  , but have also been shown to act as 'temporary inhibitors'  .. 
+PF05923 APC cysteine-rich region<br>This short region is found repeated in the mid region of the adenomatous polyposis  proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin  .. 
+PF05924 SAMP Motif<br>This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin  .. 
+PF05925 Enterobacterial virulence protein IpgD<br>Pfam-B_1987 (release 9.0). This family consists of several enterobacterial IpgD like virulence factor proteins. In the Gram-negative pathogen Shigella flexneri, the virulence factor IpgD is translocated directly into eukaryotic cells and acts as a potent inositol 4-phosphatase that specifically dephosphorylates phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] into phosphatidylinositol 5-monophosphate [PtdIns(5)P] that then accumulates. Transformation of PtdIns(4,5)P(2) into PtdIns(5)P by IpgD is responsible for dramatic morphological changes of the host cell, leading to a decrease in membrane tether force associated with membrane blebbing and actin filament remodelling  .. 
+PF05926 Phage head completion protein (GPL)<br>Pfam-B_1860 (release 9.0). This family consists of several phage head completion protein (GPL) as well as related bacterial sequences. Members of this family allow the completion of filled heads by rendering newly packaged DNA in the heads resistant to DNase. The protein is thought to bind to DNA filled capsids  .. 
+PF05927 Penaeidin<br>Pfam-B_2675 (release 9.0). This family consists of several isoforms of the penaeidin protein which is specific to shrimps. Penaeidins, a unique family of antimicrobial peptides (AMPs) with both proline and cysteine-rich domains, were initially identified in the hemolymph of the Pacific white shrimp, Litopenaeus vannamei  .  . 
+PF05928 Zea mays MURB-like protein (MuDR)<br>Pfam-B_3145 (release 9.0). This family consists of several Zea mays specific MURB-like proteins. The transposition of Mu elements underlying Mutator activity in maize requires a transcriptionally active MuDR element. Despite variation in MuDR copy number and RNA levels in Mutator lines, transposition events are consistently late in plant development, and Mu excision frequencies are similar  .. 
+PF05929 Phage capsid scaffolding protein (GPO) serine peptidase<br>Pfam-B_1730 (release 9.0). This family consists of several bacteriophage capsid scaffolding proteins (GPO) and some related bacterial sequences. GPO is thought to function in both the assembly of proheads and the cleavage of GPN  . The family is found to function as a serine peptidase, with a conserved Asp, His and Ser catalytic triad, as in subtilisin, and as represented in MEROPS:S73. The family includes SwissProt:P25478 from Enterobacteria phage P2 which cleaves itself and then becomes the scaffold protein upon which the bacteriophage prohead is built - a mechanism quite common amongst phages  .. 
+PF05930 AlpA; <br>Prophage CP4-57 regulatory protein (AlpA). Pfam-B_2048 (release 9.0). This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light  . Several of the sequences in this family are thought to be DNA-binding proteins.. 
+PF05931 Staphylococcal AgrD protein<br>Pfam-B_2868 (release 9.0). This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr  .. 
+PF05932 Tir chaperone protein (CesT) family<br>Pfam-B_2921 (release 9.0). This family consists of a number of bacterial sequences which are highly similar to the Tir chaperone protein in E. Coli. In many Gram-negative bacteria, a key indicator of pathogenic potential is the possession of a specialised type III secretion system, which is utilised to deliver virulence effector proteins directly into the host cell cytosol. Many of the proteins secreted from such systems require small cytosolic chaperones to maintain the secreted substrates in a secretion-competent state. CesT serves a chaperone function for the enteropathogenic Escherichia coli (EPEC) translocated intimin receptor (Tir) protein, which confers upon EPEC the ability to alter host cell morphology following intimate bacterial attachment  .\.     This family also contains several DspF and related sequences from several plant pathogenic bacteria. The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. DspF and AvrF are small (16 kDa and 14 kDa) and acidic with predicted amphipathic alpha helices in their C termini; they resemble chaperones for virulence factors secreted by type III secretion systems of animal pathogens  .. 
+PF05933 Fungal ATP synthase protein 8 (A6L)<br>Pfam-B_2993 (release 9.0). This family consists of fungus specific ATP synthase protein 8 (EC:3.6.3.14). The family may be related to the ATP synthase protein 8 found in other eukaryotes Pfam:PF00895.. 
+PF05934 Mid-1-related chloride channel (MCLC)<br>Pfam-B_2711 (release 9.0). This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer  .. 
+PF05935 Arylsulfotransferase (ASST)<br>Pfam-B_3266 (release 9.0). This family consists of several bacterial Arylsulfotransferase proteins. Arylsulfotransferase (ASST) transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate  . . 
+PF05936 Bacterial protein of unknown function (DUF876)<br>Pfam-B_3279 (release 9.0). This family consists of a series of hypothetical bacterial sequences of unknown function.. 
+PF05937 EB-1 Binding Domain<br>This region at the C-terminus of the APC proteins binds the microtubule-associating protein EB-1  . At the C-terminus of the alignment is also a Pfam:PF00595 binding domain. A short motif in the middle of the region appears to be found in the APC2  proteins (e.g Swiss:O95996).. 
+PF05938 Plant self-incompatibility protein S1<br>Pfam-B_3292 (release 9.0). This family consists of a series of plant proteins which are related to the Papaver rhoeas S1 self-incompatibility protein. Self incompatibility (SI) is the single most important outbreeding device found in angiosperms and is a mechanism that regulates the acceptance or rejection of pollen. S1 is known to exhibit specific pollen-inhibitory properties  .. 
+PF05939 Phage minor tail protein<br>Pfam-B_3296 (release 9.0). This family consists of a series of phage minor tail proteins and related sequences from several bacterial species.. 
+PF05940 NnrS protein<br>Pfam-B_3395 (release 9.0). This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family  . Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase  .. 
+PF05941 Chordopoxvirus A20R protein<br>Pfam-B_3744 (release 9.0). This family consists of several Chordopoxvirus A20R proteins. The A20R protein is required for DNA replication, is associated with the processive form of the viral DNA polymerase, and directly interacts with the viral proteins encoded by the D4R, D5R, and H5R open reading frames. A20R may contribute to the assembly or stability of the multiprotein DNA replication complex  .. 
+PF05942 Archaeal PaREP1/PaREP8 family<br>Pfam-B_2248 (release 9.0) & Pfam-B_9342 (release 9.0). This family consists of several archaeal PaREP1 and PaREP8 proteins the function of this family is unknown.. 
+PF05943 Protein of unknown function (DUF877)<br>Pfam-B_2566 (release 9.0). This family consists of a number of uncharacterised bacterial proteins. The function of this family is unknown.. 
+PF05944 Phage small terminase subunit<br>Pfam-B_2645 (release 9.0). This family consists of several phage small terminase subunit proteins as well as some related bacterial sequences  .. 
+PF05946 Toxin-coregulated pilus subunit TcpA<br>Pfam-B_3639 (release 9.0). This family consists of toxin-coregulated pilus subunit (TcpA) proteins from Vibrio cholerae and related sequences. The major virulence factors of toxigenic Vibrio cholerae are cholera toxin (CT), which is encoded by a lysogenic bacteriophage (CTXPhi), and toxin-coregulated pilus (TCP), an essential colonisation factor which is also the receptor for CTXPhi. The genes for the biosynthesis of TCP are part of a larger genetic element known as the TCP pathogenicity island  .. 
+PF05947 Bacterial protein of unknown function (DUF879)<br>Pfam-B_3751 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF05949 Bacterial protein of unknown function (DUF881)<br>Pfam-B_4053 (release 9.0). This family consists of a series of hypothetical bacterial proteins. One of the family members Swiss:Q45543 from Bacillus subtilis is thought to be involved in cell division and sporulation  .. 
+PF05950 Orthopoxvirus A36R protein<br>Pfam-B_4070 (release 9.0). This family consists of several Orthopoxvirus A36R proteins. The A36R protein is predicted to be a type Ib membrane protein  .. 
+PF05951 DUF882; <br>Bacterial protein of unknown function (DUF882). Pfam-B_4115 (release 9.0). This family consists of a series of hypothetical bacterial proteins of unknown function.. 
+PF05952 Bacillus competence pheromone ComX<br>Pfam-B_4222 (release 9.0). Natural genetic competence in Bacillus subtilis is controlled by quorum-sensing (QS). The ComP- ComA two-component system detects the signalling molecule ComX, and this signal is transduced by a conserved phosphotransfer mechanism. ComX is synthesised as an inactive precursor and is then cleaved and modified by ComQ before export to the extracellular environment  .. 
+PF05953 Allatostatin<br>Pfam-B_4313 (release 9.0). This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata  .. 
+PF05954 Phage late control gene D protein (GPD)<br>Pfam-B_4333 (release 9.0) & Pfam-B_12199 (release 10.0). This family includes a number of phage late control gene D proteins and related bacterial sequences.  This family also includes Bacteriophage Mu P proteins and related sequences.. 
+PF05955 Eq_herpes_Gp2; <br>Equine herpesvirus glycoprotein gp2. Pfam-B_4360 (release 9.0). This family consists of a number of glycoprotein gp2 sequences from equine herpesviruses.. 
+PF05956 APC basic domain<br>This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged  amino acids and interacts with microtubules  .. 
+PF05957 Bacterial protein of unknown function (DUF883)<br>Pfam-B_4421 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF05958 tRNA (Uracil-5-)-methyltransferase<br>Pfam-B_4661 (release 9.0). This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalysed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity  .. 
+PF05959 Nucleopolyhedrovirus protein of unknown function (DUF884)<br>Pfam-B_4679 (release 9.0). This family consists of several hypothetical Nucleopolyhedrovirus proteins of unknown function.. 
+PF05960 Bacterial protein of unknown function (DUF885)<br>Pfam-B_4405 (release 9.0). This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.. 
+PF05961 Chordopoxvirus A13L protein<br>Pfam-B_5061 (release 9.0). This family consists of A13L proteins from the Chordopoxviruses. A13L or p8 is one of the three most abundant membrane proteins of the intracellular mature Vaccinia virus  .. 
+PF05962 DUF886;<br>Pfam-B_5160 (release 9.0). HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterised repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription  . The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.. 
+PF05963 Cytomegalo_US3; <br>Cytomegalovirus US3 protein. Pfam-B_7187 (release 9.0). US3 of human cytomegalovirus is an endoplasmic reticulum resident transmembrane glycoprotein that binds to major histocompatibility complex class I molecules and prevents their departure. The endoplasmic reticulum retention signal of the US3 protein is contained in the luminal domain of the protein  .. 
+PF05964 F/Y-rich N-terminus<br>Pfam-B_1170 (release 8.0). This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.. 
+PF05965 F/Y rich C-terminus<br>Pfam-B_1170 (release 8.0). This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542.. 
+PF05966 Chordopoxvirus A33R protein<br>Pfam-B_4799 (release 9.0). This family consists of several Chordopoxvirus A33R proteins. A33R plays a role in promoting Ab-resistant cell-to-cell spread of virus   and interacts with A36R to incorporate the protein into the outer membrane of intracellular enveloped virions (IEV)  .. 
+PF05968 Bacillus PapR protein<br>Pfam-B_4892 (release 9.0). This family consists of the Bacillus species specific PapR protein. The papR gene belongs to the PlcR regulon and is located 70 bp downstream from plcR. It encodes a 48-amino-acid peptide. Disruption of the papR gene abolishes expression of the PlcR regulon, resulting in a large decrease in haemolysis and virulence in insect larvae. A processed form of PapR activates the PlcR regulon by allowing PlcR to bind to its DNA target. This activating mechanism is strain specific  .. 
+PF05969 DUF888;<br>Photosystem II complex subunit Ycf12. Pfam-B_4945 (release 9.0). Ycf12 has been identified as a core subunit in the photosystem II (PSII) complex [1-2].  PsbZ has been shown to be required for the association of PsbK and Ycf12 with PSII  .. 
+PF05970 DUF889;<br>Pfam-B_4988 (release 9.0). This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated   . This family includes a large number of largely uncharacterised plant proteins.  This family includes a P-loop motif that is involved in nucleotide binding.. 
+PF05971 DUF890; <br>Protein of unknown function (DUF890). Pfam-B_5064 (release 9.0). This family consists of several conserved hypothetical proteins from both eukaryotes and prokaryotes. The function of this family is unknown.. 
+PF05972 APC 15 residue motif<br>This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin   along with the Pfam:PF05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.. 
+PF05973 DUF891; <br>Phage derived protein Gp49-like (DUF891). Pfam-B_5075 (release 9.0) & Pfam-B_6067 (release 14.0). This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.. 
+PF05974 Domain of unknown function (DUF892)<br>Pfam-B_5115 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF05975 Bacterial ABC transporter protein EcsB<br>Pfam-B_4764 (release 9.0). This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters  .. 
+PF05977 DUF894;<br>Transmembrane secretion effector. Moxon SJ, Eberhardt R. Pfam-B_4880 (release 9.0). This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin  , and a protein involved in antibiotic resistance  .. 
+PF05978 DUF895; UNC-93_Ce; <br>Ion channel regulatory protein UNC-93. Moxon SJ, Pollington J. Pfam-B_4965 (release 9.0). This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein  .. 
+PF05979 Bacterial protein of unknown function (DUF896)<br>Pfam-B_5209 (release 9.0). In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC  . This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex  . Structural modelling suggests this domain may bind nucleic acids  . This family is also known as UPF0291.. 
+PF05980 toxin_7;<br>Pfam-B_5254 (release 9.0). This family consists of several short spider neurotoxin proteins including many from the Funnel-web spider.. 
+PF05981 CreA protein<br>Pfam-B_5258 (release 9.0). This family consists of several bacterial CreA proteins, the function of which is unknown.. 
+PF05982 Domain of unknown function (DUF897) <br>Pfam-B_8040 (release 9.0). Family of bacterial proteins with unknown function. 
+PF05983 MED7; <br>Pfam-B_5278 (release 9.0). This family consists of several eukaryotic proteins which are homologues of the yeast MED7 protein. Activation of gene transcription in metazoans is a multi-step process that is triggered by factors that recognise transcriptional enhancer sites in DNA. These factors work with co-activators such as MED7 to direct transcriptional initiation by the RNA polymerase II apparatus  .. 
+PF05984 Cytomegalovirus UL20A protein<br>Pfam-B_5345 (release 9.0). This family consists of several Cytomegalovirus UL20A proteins. UL20A is thought to be a glycoprotein  .. 
+PF05985 Ethanolamine ammonia-lyase light chain (EutC)<br>Pfam-B_5363 (release 9.0). This family consists of several bacterial ethanolamine ammonia-lyase light chain (EutC) EC:4.3.1.7 sequences. Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia  .  . 
+PF05986 ADAM-TS Spacer 1<br>Pfam-B_1693 (release 8.0). This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases  .. 
+PF05987 Bacterial protein of unknown function (DUF898)<br>Pfam-B_5347 (release 9.0). This family consists of several bacterial proteins of unknown function. Some of the family members are described as putative membrane proteins.. 
+PF05988 Bacterial protein of unknown function (DUF899)<br>Pfam-B_5437 (release 9.0). This family consists of several uncharacterised bacterial proteins of unknown function.. 
+PF05989 Chordopoxvirus A35R protein<br>Pfam-B_5472 (release 9.0). This family consists of several Chordopoxvirus sequences homologous to the Vaccinia virus A35R protein. The function of this family is unknown.. 
+PF05990 Alpha/beta hydrolase of unknown function (DUF900)<br>Pfam-B_5475 (release 9.0). This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.. 
+PF05991 DUF901;<br>YacP-like NYN domain. Pfam-B_5522 (release 9.0). This family consists of bacterial proteins related to YacP. This family is uncharacterised functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind  .  Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA  .. 
+PF05992 SbmA/BacA-like family<br>Pfam-B_8139 (release 9.0). The Rhizobium meliloti bacA gene encodes a function that is essential for  bacterial differentiation into bacteroids within plant cells in the symbiosis between R. meliloti and alfalfa. An Escherichia coli homolog of  BacA, SbmA, is implicated in the uptake of microcins and bleomycin.  This family is likely to be a subfamily of the ABC transporter family.. 
+PF05993 Reovirus major virion structural protein Mu-1/Mu-1C (M2)<br>Pfam-B_5584 (release 9.0). This family consists of several Reovirus major virion structural protein Mu-1/Mu-1C (M2) sequences. This family is family is thought to play a role in host cell membrane penetration  .. 
+PF05994 Cytoplasmic Fragile-X interacting family<br>Pfam-B_8072 (release 9.0). CYFIP1/2 (Cytoplasmic fragile X mental retardation interacting protein) like proteins for a  highly conserved protein family  .  The function of CYFIPs is unclear, but CYFIP interaction with fragile X mental  retardation interacting protein (FMRP) involves the domain of FMRP  which also mediating homo- and heteromerization  .. 
+PF05995 Cysteine dioxygenase type I<br>Pfam-B_8006 (release 9.0). Cysteine dioxygenase type I (EC:1.13.11.20) converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate  production.. 
+PF05996 Ferredoxin-dependent bilin reductase<br>Pfam-B_5667 (release 9.0). This family consists of several different but closely related proteins which include phycocyanobilin:ferredoxin oxidoreductase EC:1.3.7.5 (PcyA), 15,16-dihydrobiliverdin:ferredoxin oxidoreductase EC:1.3.7.2 (PebA) and phycoerythrobilin:ferredoxin oxidoreductase EC:1.3.7.3 (PebB). Phytobilins are linear tetrapyrrole precursors of the light-harvesting prosthetic groups of the phytochrome photoreceptors of plants and the phycobiliprotein photosynthetic antennae of cyanobacteria, red algae, and cryptomonads. It is known that that phytobilins are synthesised from heme via the intermediary of biliverdin IX alpha (BV), which is reduced subsequently by ferredoxin-dependent bilin reductases with different double-bond specificities  . . 
+PF05997 Nucleolar protein,Nop52<br>Pfam-B_8003 (release 9.0). Nop52 believed to be involved in the generation of 28S rRNA  .. 
+PF05999 Herpesvirus U5-like family<br>Pfam-B_8027 (release 9.0). This family of Herpesvirus includes U4, U5 and UL27.. 
+PF06001 Domain of Unknown Function (DUF902)<br>Pfam-B_3539 (release 8.0). This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein, which is an acetyltransferase that acetylates histones, giving a specific tag for transcriptional activation. This short domain is found to the C-terminus of bromodomains. The 40 residue domain contains four conserved cysteines suggesting that it may be stabilised by a zinc ion. In CREB this domain is to the N-terminus of another zinc binding PHD domain.. 
+PF06002 Alpha-2,3-sialyltransferase (CST-I)<br>Pfam-B_6887 (release 9.0). This family consists of several alpha-2,3-sialyltransferase (CST-I) proteins largely found in Campylobacter jejuni.. 
+PF06003 Survival motor neuron protein (SMN)<br>Pfam-B_7026 (release 9.0). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs  . . 
+PF06004 Bacterial protein of unknown function (DUF903)<br>Pfam-B_7037 (release 9.0). This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown.. 
+PF06005 Protein of unknown function (DUF904)<br>Pfam-B_7038 (release 9.0). This family consists of several bacterial and archaeal hypothetical proteins of unknown function.. 
+PF06006 Bacterial protein of unknown function (DUF905)<br>Pfam-B_7072 (release 9.0). This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in Pfam:PF03646.. 
+PF06007 Phosphonate metabolism protein PhnJ<br>Pfam-B_7179 (release 9.0). This family consists of several bacterial phosphonate metabolism (PhnJ) sequences. The exact role that PhnJ plays in phosphonate utilisation is unknown.. 
+PF06008 Laminin Domain I<br>Pfam-B_1925 (release 8.0). coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure  .. 
+PF06009 Laminin Domain II<br>Pfam-B_1925 (release 8.0). It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure  .. 
+PF06011 DUF907; <br>Transient receptor potential (TRP) ion channel. Moxon SJ, Mistry J, Wood V. Pfam-B_5564 (release 9.0). This family of proteins are transient receptor potential (TRP) ion channels.\. They are essential for cellular viability and are involved in cell growth and cell wall synthesis  .  The genes for these proteins are homologous to polycystic kidney disease related ion channel genes  .. 
+PF06012 Domain of Unknown Function (DUF908)<br>Pfam-B_6534 (release 8.0). 
+PF06013 DUF909; <br>Proteins of 100 residues with WXG. Pfam-B_7198 (release 9.0). ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. Homologues have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the Pfam:PF01580 domains in the YukA-like proteins  .. 
+PF06014 Bacterial protein of unknown function (DUF910)<br>Pfam-B_7253 (release 9.0). This family consists of several short bacterial proteins of unknown function.. 
+PF06015 Chordopoxvirus A30L protein<br>Pfam-B_7254 (release 9.0). This family consists of several short Chordopoxvirus proteins which are homologous to the A30L protein of Vaccinia virus. The vaccinia virus A30L protein is required for the association of electron-dense, granular, proteinaceous material with the concave surfaces of crescent membranes, an early step in viral morphogenesis. A30L is known to interact with the G7L protein and it has been shown that the stability of each is dependent on its association with the other  .. 
+PF06016 Reovirus core-spike protein lambda-2 (L2)<br>Pfam-B_7350 (release 9.0). This family consists of several Reovirus core-spike protein lambda-2 (L2) sequences. The reovirus L2 genome segment encodes the core spike protein lambda-2, which mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts  .. 
+PF06017 M_tail; Myosin_tail_2; <br>Pfam-B_12631 (release 8.0). 
+PF06018 CodY GAF-like domain<br>Pfam-B_7573 (release 9.0). This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. Presumably this domain is involved in GTP binding. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions  . The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk  .. 
+PF06019 Phage GP30.8 protein<br>Pfam-B_7692 (release 9.0). This family consists of several GP30.8 proteins from the T4-like phages. The function of this family is unknown.. 
+PF06020 Drosophila roughex protein<br>Pfam-B_7712 (release 9.0). This family consists of several roughex (RUX) proteins specific to Drosophila species. Roughex can influence the intracellular distribution of cyclin A and is therefore defined as a distinct and specialised cell cycle  inhibitor for cyclin A-dependent kinase activity  . Rux is though to regulate the metaphase to anaphase transition during development  .. 
+PF06021 Glycine_acyl_tr;<br>Aralkyl acyl-CoA:amino acid N-acyltransferase. Pfam-B_7828 (release 9.0). This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.. 
+PF06022 Plasmodium variant antigen protein Cir/Yir/Bir<br>Pfam-B_8754 (release 9.0). This family consists of several Cir, Yir and Bir proteins from the Plasmodium species P.chabaudi, P.yoelii and P.berghei.. 
+PF06023 Archaeal protein of unknown function (DUF911)<br>Pfam-B_8782 (release 9.0). This family consists of several archaeal proteins of unknown function.. 
+PF06024 Nucleopolyhedrovirus protein of unknown function (DUF912)<br>Pfam-B_8809 (release 9.0). This family consists of several Nucleopolyhedrovirus proteins of unknown function.. 
+PF06025 Domain of Unknown Function (DUF913)<br>Pfam-B_6534 (release 8.0). Members of this family are found in various ubiquitin protein ligases.. 
+PF06026 Ribose 5-phosphate isomerase A (phosphoriboisomerase A)<br>Pfam-B_5144 (release 9.0). This family consists of several ribose 5-phosphate isomerase A or phosphoriboisomerase A (EC:5.3.1.6) from bacteria, eukaryotes and archaea. . 
+PF06027 Eukaryotic protein of unknown function (DUF914)<br>Pfam-B_7017 (release 9.0). This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.. 
+PF06028 Alpha/beta hydrolase of unknown function (DUF915)<br>Pfam-B_7094 (release 9.0). This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.. 
+PF06029 AlkA N-terminal domain<br>Pfam-B_13157 (release 8.0). 
+PF06030 Bacterial protein of unknown function (DUF916)<br>Pfam-B_7106 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06031 SERTA motif<br>Pfam-B_7533 (Release 9.0). This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins  . The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif  .. 
+PF06032 Protein of unknown function (DUF917)<br>Pfam-B_7195 (release 9.0). This family consists of hypothetical bacterial and archaeal proteins of unknown function.. 
+PF06033 Nucleopolyhedrovirus protein of unknown function (DUF918)<br>Pfam-B_7213 (release 9.0). This family consists of several Nucleopolyhedrovirus proteins with no known function.. 
+PF06034 Nucleopolyhedrovirus protein of unknown function (DUF919)<br>Pfam-B_7250 (release 9.0). This family consists of several short Nucleopolyhedrovirus proteins of unknown function.. 
+PF06035 DUF920; BTLCP;<br>Bacterial transglutaminase-like cysteine proteinase BTLCP. Moxon SJ, Sammut SJ, Eberhardt R. Pfam-B_7277 (release 9.0). Members of this family are predicted to be bacterial transglutaminase-like cysteine proteinases. They contain a conserved Cys-His-Asp catalytic triad. Their structure is predicted to be similar to that of Salmonella typhimurium N-hydroxyarylamine O-acetyltransferase Swiss:Q00267, in Pfam:PF00797, however they lack the sub-domain which is important for arylamine recognition  .. 
+PF06037 Bacterial protein of unknown function (DUF922)<br>Pfam-B_7397 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06039 Malate:quinone oxidoreductase (Mqo)<br>Pfam-B_7465 (release 9.0). This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidises L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators  .  . 
+PF06040 Adenovirus_E3; <br>Adenovirus E3 protein. Pfam-B_7475 (release 9.0). This family consists of several Adenovirus E3 proteins. The E3 protein does not seem to be essential for virus replication in cultured cells suggesting that the protein may function in virus-host interactions  . . 
+PF06041 Bacterial protein of unknown function (DUF924)<br>Pfam-B_7600 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06042 Bacterial protein of unknown function (DUF925)<br>Pfam-B_7663 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function. This family was recently identified as belonging to the nucleotidyltransferase superfamily  .. 
+PF06043 Reovirus P9-like family<br>Pfam-B_8265 (release 9.0). 
+PF06044 Dam-replacing family<br>Pfam-B_8314 (release 9.0). Dam-replacing protein (DRP) is an restriction endonuclease that is flanked by pseudo-transposable small repeat elements.  The replacement of Dam-methylase by DRP allows phase variation through slippage-like mechanisms in several pathogenic isolates of Neisseria meningitidis  .. 
+PF06045 Rhamnogalacturonate lyase family<br>Pfam-B_8355 (release 9.0). Rhamnogalacturonate lyase (EC:4.2.2.-) degrades the rhamnogalacturonan  I (RG-I) backbone of pectin  .  This family contains mainly members from plants, but also contains the plant pathogen Erwinia chrysanthemi.. 
+PF06046 Exocyst complex component Sec6<br>Pfam-B_8361 (release 9.0). Sec6 is a component of the multiprotein exocyst complex.  Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localise to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner  .. 
+PF06047 DUF926; <br>Ras-induced vulval development antagonist. Pfam-B_8083 (release 9.0). This family is from synthetic multi-vulval genes which encode chromatin-associated proteins involved in transcriptional repression. This protein has a role in antagonising Ras-induced vulval development  .. 
+PF06048 Domain of unknown function (DUF927)<br>Pfam-B_8364 (release 9.0). Family of bacterial proteins of unknown function. The C-terminal half of this family contains a P-loop motif.. 
+PF06049 Coagulation Factor V LSPD Repeat<br>These repeats are found in coagulation factor V (five). The name LSPD derives from the conserved residues in the middle of the repeat.They occur in the B domain, which is cleaved prior to activation of the protein. It has been suggested that domain B bring domains A and C together for activation ( ).. 
+PF06050 2-hydroxyglutaryl-CoA dehydratase, D-component <br>Pfam-B_8369 (release 9.0). Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalysed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate  .. 
+PF06051 Domain of Unknown Function (DUF928)<br>Pfam-B_8442 (release 9.0). Family of uncharacterised bacterial protein.. 
+PF06052 3-hydroxyanthranilic acid dioxygenase<br>Pfam-B_8515 (release 9.0). In eukaryotes 3-hydroxyanthranilic acid dioxygenase (EC:1.13.11.6) is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid  .The prokaryotic homolog is involved in the 2-nitrobenzoate degradation pathway  .. 
+PF06053 Domain of unknown function (DUF929)<br>Pfam-B_8458 (release 9.0). Family of proteins from the archaeon Sulfolobus, with undetermined  function.. 
+PF06054 Competence protein CoiA-like family<br>Pfam-B_8535 (release 9.0). Many of the members of this family are described as transcription factors.  CoiA falls within a competence-specific operon in  Streptococcus.  CoiA is an uncharacterised protein.. 
+PF06055 Exopolysaccharide synthesis, ExoD<br>Pfam-B_8604 (release 9.0). Among the bacterial genes required for nodule invasion are the exo genes. These genes are involved in the production of an extracellular polysaccharide.  Mutations in the exoD result in altered exopolysaccharide production and defects in nodule invasion  .. 
+PF06056 Putative ATPase subunit of terminase (gpP-like)<br>Pfam-B_7152 (release 9.0). This family of proteins are annotated as ATPase subunits of phage terminase after  . Terminases are viral proteins that are involved in packaging viral DNA into the capsid.. 
+PF06057 Bacterial virulence protein (VirJ)<br>Pfam-B_7524 (release 9.0). This family consists of several bacterial VirJ virulence proteins. VirJ is thought to be involved in the type IV secretion system. It is thought that the substrate proteins localised to the periplasm may associate with the pilus in a manner that is mediated by VirJ, and suggest a two-step process for type IV secretion in Agrobacterium  .. 
+PF06058 Dcp1-like decapping family<br>Pfam-B_8271 (release 9.0). An essential step in mRNA turnover is decapping.  In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2 (Pfam:PF05026).  The precise role of these proteins in the decapping reaction have not been established. Evidence suggests that the Dcp1 may enhance the function of Dcp2  .. 
+PF06059 Domain of Unknown Function (DUF930)<br>Pfam-B_8283 (release 9.0). Family of bacterial proteins with undetermined function.  All bacteria in this family are from the Rhizobiales order. . 
+PF06060 Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)<br>Pfam-B_8552 (release 9.0). This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known [1,2].. 
+PF06061 Baculoviridae ME53<br>Pfam-B_8086 (release 9.0). ME53 is one of the major early-transcribed genes. The ME53 protein is reported to contain a putative zinc finger motif  .. 
+PF06062 Uncharacterised protein family (UPF0231)<br>Pfam-B_9027 (release 9.0). Family of uncharacterised Proteobacteria proteins.. 
+PF06064 Host-nuclease inhibitor protein Gam<br>Pfam-B_9063 (release 9.0). The Gam protein inhibits RecBCD nuclease and is found in both bacteria and bacteriophage  .. 
+PF06066 SepZ<br>Pfam-B_9064 (release 9.0). SepZ is a component of the type III secretion system use in bacteria. SepZ is a gene within the enterocyte effacement locus. SepZ mutants exhibit reduced invasion efficiency and lack of tyrosine phosphorylation  of Hp90  .. 
+PF06067 Domain of unknown function (DUF932)<br>Pfam-B_9083 (release 9.0) & Pfam-B_002957 (release 23.0). Family of prokaryotic proteins with unknown function. Contains a number of highly conserved polar residues that could suggest an enzymatic activity.. 
+PF06068 TIP49 C-terminus<br>Pfam-B_9170 (release 9.0). This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway  . TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases  . . 
+PF06069 PerC transcriptional activator<br>Pfam-B_9117 (release 9.0). PerC is a transcriptional activator of EaeA/BfpA expression in enteropathogenic bacteria  .. 
+PF06070 Herpesvirus large structural phosphoprotein UL32<br>Pfam-B_9125 (release 9.0). The large phosphorylated protein (UL32-like) of herpes viruses  is the polypeptide most frequently reactive in immuno-blotting analyses with antisera when compared with other viral proteins  .. 
+PF06071 DUF933; <br>Protein of unknown function (DUF933). Pfam-B_10000 (release 9.0). This domain is found at the C terminus of the YchF GTP-binding protein (Swiss:O13998) and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies. . 
+PF06072 Alphaherpesvirus tegument protein US9<br>Pfam-B_7164 (release 9.0). This family consists of several US9 and related proteins from the Alphaherpesviruses. The function of the US9 protein is unknown although in Bovine herpesvirus 5 Us9 is essential for the anterograde spread of the virus from the olfactory mucosa to the bulb  .. 
+PF06073 Bacterial protein of unknown function (DUF934)<br>Pfam-B_8947 (release 9.0). This family consists of several bacterial proteins of unknown function. One of the members of this family Swiss:Q8YEW3 is thought to be an oxidoreductase.. 
+PF06074 Protein of unknown function (DUF935)<br>Pfam-B_10021 (release 9.0). This family consists of several bacterial proteins of unknown function as well as the Bacteriophage Mu gp29 protein Swiss:Q9T1W5.. 
+PF06075 Plant protein of unknown function (DUF936)<br>Pfam-B_10047 (release 9.0). This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.. 
+PF06076 Orthopoxvirus F14 protein<br>Pfam-B_10072 (release 9.0). This family consists of several short Orthopoxvirus F14 proteins. The function of this protein is unknown.. 
+PF06078 Bacterial protein of unknown function (DUF937)<br>Pfam-B_7321 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06079 SHAPY;<br>Pfam-B_7593 (release 9.0). This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate.  . . 
+PF06080 Protein of unknown function (DUF938)<br>Pfam-B_8833 (release 9.0). This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.. 
+PF06081 Bacterial protein of unknown function (DUF939)<br>Pfam-B_8873 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06082 Bacterial putative lipoprotein (DUF940)<br>Pfam-B_9128 (release 9.0). This family consists of hypothetical bacterial proteins several of which are described as putative lipoproteins.. 
+PF06083 Interleukin-17<br>Pfam-B_9152 (release 9.0). IL-17 is a potent proinflammatory cytokine produced by  activated memory T cells  . The IL-17 family is thought to represent a distinct signaling system that  appears to have been highly conserved across vertebrate evolution  .. 
+PF06084 Cytomegalovirus TRL10 protein<br>Pfam-B_8875 (release 9.0). This family consists of several Cytomegalovirus TRL10 proteins. TRL10 represents a structural component of the virus particle and like the other HCMV envelope glycoproteins, is present in a disulfide-linked complex  . . 
+PF06085 Lipoprotein Rz1 precursor<br>Pfam-B_8925 (release 9.0). This family consists of several bacteria and phage lipoprotein Rz1 precursors. Rz1 is a proline-rich lipoprotein from bacteriophage lambda which is known to have fusogenic properties. Rz1-induced liposome fusion is thought to be mediated primarily by the generation of local perturbation in the bilayer lipid membrane and to a lesser extent by electrostatic forces  . This family Rz1 and the Rz protein Rz (Pfam:PF03245) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway  .. 
+PF06086 Orthopoxvirus A26L/A30L protein<br>Pfam-B_8938 (release 9.0). This family consists of several Orthopoxvirus A26L and A30L proteins. The Vaccinia A30L gene is regulated by a late promoter and encodes a protein of approximately 9 kDa. It is thought that the A30L protein is needed for vaccinia virus morphogenesis, specifically the association of the dense viroplasm with viral membranes  .. 
+PF06087 Tyrosyl-DNA phosphodiesterase<br>Pfam-B_8155 (release 9.0). Covalent intermediates between topoisomerase I and DNA  can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between  topoisomerase I and DNA  .. 
+PF06088 Nucleopolyhedrovirus telokin-like protein-20 (TLP20)<br>Pfam-B_7657 (release 9.0). This family consists of several Nucleopolyhedrovirus telokin-like protein-20 (TLP20) sequences. The function of this family is unknown but TLP20 is known to shares some antigenic similarities to the smooth muscle protein telokin although the amino acid sequence shows no homologies to telokin  .. 
+PF06089 L-asparaginase II<br>Pfam-B_7673 (release 9.0). This family consists of several bacterial L-asparaginase II proteins.  L-asparaginase (EC:3.5.1.1) catalyses the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source  .. 
+PF06090 DUF941; <br>Inositol-pentakisphosphate 2-kinase. Pfam-B_9098 (release 9.0). This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase).\.  This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.. 
+PF06092 Enterobacterial putative membrane protein (DUF943)<br>Pfam-B_7843 (release 9.0). This family consists of several hypothetical putative membrane proteins from Escherichia coli, Yersinia pestis and Salmonella typhi.. 
+PF06093 Spt4/RpoE2 zinc finger<br>Pfam-B_7906 (release 9.0) & COG2093. This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2  . Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles  .  RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in  . The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.. 
+PF06094 AIG2-like family<br>Pfam-B_9771 (release 9.0). AIG2 is an Arabidopsis proteins that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2  .. 
+PF06096 Baculo_8Kda; <br>Baculoviridae 8.2 KDa protein. Pfam-B_8370 (release 9.0). Family of proteins from various Baculoviruses with undetermined function.. 
+PF06097 Bacterial protein of unknown function (DUF945)<br>Pfam-B_9171 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06098 Radial spoke protein 3<br>Pfam-B_9453 (release 9.0). This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organisms from protists to humans. They are centred by precisely organised, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation  .. 
+PF06099 Phenol hydroxylase subunit<br>Pfam-B_10062 (release 9.0). This family consists of several bacterial phenol hydroxylase subunit proteins which are part of a multicomponent phenol hydroxylase. Some bacteria can utilise phenol or some of its methylated derivatives as their sole source of carbon and energy. The first step in this process is the conversion of phenol into catechol. Catechol is then further metabolised via the meta-cleavage pathway into TCA cycle intermediates  . . 
+PF06100 Streptococcal 67 kDa myosin-cross-reactive antigen like family <br>Pfam-B_9995 (release 9.0). Members of this family are thought to have structural features in  common with the beta chain of the class II antigens, as well as myosin,  and may play an important role in the pathogenesis .. 
+PF06101 Plant protein of unknown function (DUF946)<br>Pfam-B_10066 (release 9.0). This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.. 
+PF06102 Domain of unknown function (DUF947)<br>Pfam-B_9959 (release 9.0). Family of eukaryotic proteins with unknown function.. 
+PF06103 Bacterial protein of unknown function (DUF948)<br>Pfam-B_10104 (release 9.0). This family consists of bacterial sequences several of which are thought to be general stress proteins.. 
+PF06105 Aph-1 protein<br>Pfam-B_7927 (release 9.0). This family consists of several eukaryotic Aph-1 proteins.Gamma-secretase catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. It is thought that the presenilin heterodimer comprises the catalytic site and that a highly glycosylated form of nicastrin associates with it. Aph-1 and Pen-2, two membrane proteins genetically linked to gamma-secretase, associate directly with presenilin and nicastrin in the active protease complex. Co-expression of all four proteins leads to marked increases in presenilin heterodimers, full glycosylation of nicastrin, and enhanced gamma-secretase activity  .. 
+PF06106 Staphylococcus protein of unknown function (DUF950)<br>Pfam-B_8992 (release 9.0). This family consists of several hypothetical proteins from different Staphylococcus species. The function of this family is unknown.. 
+PF06107 Bacterial protein of unknown function (DUF951)<br>Moxon SJ, Eberhardt R. Pfam-B_8994 (release 9.0). This family consists of several short hypothetical bacterial proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF06108 Protein of unknown function (DUF952)<br>Pfam-B_8995 (release 9.0). This family consists of several hypothetical bacterial and plant proteins of unknown function.. 
+PF06109 Haemolysin E (HlyE)<br>Pfam-B_9001 (release 9.0). This family consists of several enterobacterial haemolysin (HlyE) proteins.Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. HlyE is unrelated to the well characterised pore-forming E. coli hemolysins of the RTX family, haemolysin A (HlyA), and the enterohaemolysin encoded by the plasmid borne ehxA gene of E. coli 0157. However, it is evident that expression of HlyE in the absence of the RTX toxins is sufficient to give a hemolytic phenotype in E. coli. HlyE is a protein of 34 kDa that is expressed during anaerobic growth of E. coli. Anaerobic expression is controlled by the transcription factor, FNR, such that, upon ingestion and entry into the anaerobic mammalian intestine, HlyE is produced and may then contribute to the colonisation of the host  .. 
+PF06110 Eukaryotic protein of unknown function (DUF953)<br>Pfam-B_9087 (release 9.0). This family consists of several hypothetical eukaryotic proteins of unknown function.. 
+PF06112 Gammaherpesvirus capsid protein<br>Pfam-B_9200 (release 9.0). This family consists of several Gammaherpesvirus capsid proteins. The exact function of this family is unknown.. 
+PF06113 Brain and reproductive organ-expressed protein (BRE)<br>Pfam-B_9280 (release 9.0). This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induced-NF-kappaB activation upon over expression. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene.Compared to normal cells, immortalised human cell lines uniformly express higher levels of BRE. Peripheral blood monocytes respond to LPS by down-regulating the expression of all the BRE isoforms.It is thought that the function of BRE and its isoforms is to regulate peroxisomal activities  .. 
+PF06114 Domain of unknown function (DUF955)<br>Family of bacterial and viral proteins with undetermined function. A conserved H-E-X-X-H motif is suggestive of a catalytic active site and shows similarity to Pfam:PF01435.. 
+PF06115 Domain of unknown function (DUF956)<br>Pfam-B_9146 (release 9.0). Family of bacterial sequences with undetermined function.. 
+PF06116 Transcriptional activator RinB<br>Pfam-B_9294 (release 9.0). This family consists of several Staphylococcus aureus bacteriophage RinB proteins and related sequences from their host. The int gene of staphylococcal bacteriophage phi 11 is the only viral gene responsible for the integrative recombination of phi 11. rinA and rinB, are both required to activate expression of the int gene  .. 
+PF06117 Enterobacterial protein of unknown function (DUF957)<br>Pfam-B_9300 (release 9.0). This family consists of several hypothetical proteins from Escherichia coli, Salmonella typhi, Shigella flexneri and Proteus vulgaris. The function of this family is unknown.. 
+PF06119 DUF958; <br>Yeats C, Myerscough N. Pfam-B_1159 (release 8.0). This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function  .. 
+PF06120 Tail length tape measure protein<br>Pfam-B_10088 (release 9.0). This family consists of the tail length tape measure protein from bacteriophage HK97 and related sequences from Escherichia coli O157:H7.. 
+PF06121 Domain of Unknown Function (DUF959) <br>Pfam-B_25471 (release 8.0). This N-terminal domain is not expressed in the 'Short' isoform of Collagen A  .. 
+PF06122 Conjugative relaxosome accessory transposon protein<br>Pfam-B_10166 (release 9.0). The TraH protein is thought to be a relaxosome accessory component, also necessary for transfer but not for H-pilus synthesis within the conjugative transposon    .. 
+PF06123 Inner membrane protein CreD<br>Pfam-B_10187 (release 9.0). This family consists of several bacterial CreD or Cet inner membrane proteins. Dominant mutations of the cet gene of Escherichia coli result in tolerance to colicin E2 and increased amounts of an inner membrane protein with an Mr of 42,000. The cet gene is shown to be in the same operon as the phoM gene, which is required in a phoR background for expression of the structural gene for alkaline phosphatase, phoA. Although the Cet protein is not required for phoA expression, it has been suggested that the Cet protein has an enhancing effect on the transcription of phoA  .. 
+PF06124 Staphylococcal protein of unknown function (DUF960)<br>Pfam-B_10198 (release 9.0). This family consists of several hypothetical proteins from several species of Staphylococcus. The function of this family is unknown.. 
+PF06125 Bacterial protein of unknown function (DUF961)<br>Pfam-B_10221 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06126 Herpesvirus Latent membrane protein 2<br>Pfam-B_9147 (release 9.0). Family of Kaposi's sarcoma-associated herpesvirus (HHV8) latent membrane protein.. 
+PF06127 Protein of unknown function (DUF962)<br>Pfam-B_10320 (release 9.0). This family consists of several eukaryotic and prokaryotic proteins of unknown function. The yeast protein Swiss:P25338 has been found to be non-essential for cell growth.. 
+PF06128 Shigella flexneri OspC protein<br>Pfam-B_10333 (release 9.0). This family consists of the Shigella flexneri specific protein OspC. The function of this family is unknown but it is thought that Osp proteins may be involved in post invasion events related to virulence. Since bacterial pathogens adapt to multiple environments during the course of infecting a host, it has been proposed that Shigella evolved a mechanism to take advantage of a unique intracellular cue, which is mediated through MxiE, to express proteins when the organism reaches the eukaryotic cytosol  . . 
+PF06129 Chordopoxvirus G3 protein<br>Pfam-B_10417 (release 9.0). This family consists of several Chordopoxvirus specific G3 proteins. The function of this family is unknown.. 
+PF06130 Propanediol utilisation protein PduL<br>Pfam-B_10447 (release 9.0). 
+PF06131 Schizosaccharomyces pombe repeat of unknown function (DUF963)<br>Pfam-B_10581 (release 9.0). This family consists of a series of repeated sequences from one hypothetical protein (Swiss:Q96WV6) found in Schizosaccharomyces pombe. The function of this family is unknown.. 
+PF06133 Protein of unknown function (DUF964)<br>Pfam-B_10600 (release 9.0). This family consists of several relatively short bacterial and archaeal hypothetical sequences. The function of this family is unknown.. 
+PF06134 L-rhamnose isomerase (RhaA)<br>Pfam-B_10641 (release 9.0). This family consists of several bacterial L-rhamnose isomerase proteins (EC:5.3.1.14).. 
+PF06135 Bacterial protein of unknown function (DUF965)<br>Pfam-B_10661 (release 9.0). This family consists of several hypothetical bacterial proteins. The function of the family is unknown.. 
+PF06136 Domain of unknown function (DUF966)<br>Pfam-B_8637 (release 9.0). Family of plant proteins with unknown function.. 
+PF06138 Chordopoxvirus E11 protein<br>Pfam-B_10685 (release 9.0). This family consists of several Chordopoxvirus E11 proteins. The E11 gene of vaccinia virus encodes a 15-kDa polypeptide. Mutations in the E11 gene makes the virus temperature-sensitive due to either the fact that virus infectivity requires a threshold level of active E11 protein or that E11 function is conditionally essential  . . 
+PF06139 BphX-like<br>Pfam-B_8664 (release 9.0). Family of bacterial proteins located in the phenyl dioxygenase  (bph) operon. The function of this family is unknown. . 
+PF06140 Interferon-induced 6-16 family <br>Pfam-B_9299 (release 9.0). 
+PF06141 Phage minor tail protein U<br>Pfam-B_9209 (release 9.0). Tail fibre component U of bacteriophage.. 
+PF06143 Baculovirus 11 kDa family<br>Pfam-B_9424 (release 9.0). Family of uncharacterised Baculovirus proteins that are all about 11 kDa in size.. 
+PF06144 DNA polymerase III, delta subunit<br>Pfam-B_9452 (release 9.0). DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction  . The delta subunit is also known as HolA.. 
+PF06145 Coronavirus nonstructural protein NS1<br>Pfam-B_9242 (release 9.0). Bovine coronavirus NS1 encodes a 4.9 kDa protein  .. 
+PF06146 Phosphate-starvation-inducible E<br>Pfam-B_8639 (release 9.0). Phosphate-starvation-inducible E (PsiE) expression is under direct positive and negative control by PhoB and cAMP-CRP, respectively  .  The function of PsiE remains to be determined.. 
+PF06147 Protein of unknown function (DUF968)<br>Pfam-B_9463 (release 9.0). Family of uncharacterised prophage proteins that  are also found in bacteria and eukaryotes.. 
+PF06148 COG (conserved oligomeric Golgi) complex component, COG2<br>Pfam-B_9559 (release 9.0). The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function  . The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs  .. 
+PF06149 Protein of unknown function (DUF969)<br>Pfam-B_9723 (release 9.0). Family of uncharacterised bacterial membrane proteins.. 
+PF06150 ChaB<br>Pfam-B_7743 (release 9.0). This family of proteins contain a conserved 60 residue region.  This protein is known as ChaB in E. coli and is found next to ChaA which is a cation transporter protein.  ChaB may be regulate ChaA function in some way.. 
+PF06151 Trehalose receptor<br>Pfam-B_9846 (release 9.0). In Drosophila, taste is perceived by gustatory neurons located in sensilla distributed on several different appendages throughout the  body of the animal.  This family represents the taste receptor sensitive to trehalose [1,2].. 
+PF06152 Phage minor capsid protein 2<br>Pfam-B_9879 (release 9.0). Family of related phage minor capsid proteins.. 
+PF06153 Protein of unknown function (DUF970)<br>Pfam-B_9915 (release 9.0). Family of uncharacterised bacterial proteins.. 
+PF06154 YagB/YeeU/YfjZ family<br>Pfam-B_7771 (release 9.0). This family of proteins includes three proteins from E. coli YagB, YeeU and YfjZ.  The function of these proteins is unknown.  They are about 120 amino acids in length.. 
+PF06155 Protein of unknown function (DUF971)<br>Pfam-B_10230 (release 9.0). This family consists of several short bacterial proteins and one sequence (Swiss:Q8RZ62) from Oryza sativa. The function of this family is unknown. . 
+PF06156 Protein of unknown function (DUF972)<br>Pfam-B_10235 (release 9.0). This family consists of several hypothetical bacterial sequences. The function of this family is unknown.. 
+PF06157 Protein of unknown function (DUF973)<br>Pfam-B_7947 (release 9.0). This family consists of several hypothetical archaeal proteins of unknown function.. 
+PF06159 Protein of unknown function (DUF974)<br>Pfam-B_9042 (release 9.0). Family of uncharacterised eukaryotic proteins.. 
+PF06160 Septation ring formation regulator, EzrA <br>Pfam-B_9703 (release 9.0). During the bacterial cell cycle, the tubulin-like cell-division protein  FtsZ polymerises into a ring structure that establishes the location of  the nascent division site.  EzrA modulates the frequency and position of  FtsZ ring formation  .. 
+PF06161 Protein of unknown function (DUF975)<br>Pfam-B_8494 (release 9.0). Family of uncharacterised bacterial proteins.. 
+PF06162 Caenorhabditis elegans protein of unknown function (DUF976)<br>Pfam-B_10032 (release 9.0). This family consists of several hypothetical Caenorhabditis elegans proteins of unknown function.. 
+PF06163 Bacterial protein of unknown function (DUF977)<br>Pfam-B_10135 (release 9.0). This family consists of several hypothetical bacterial proteins from Escherichia coli and Salmonella typhi. The function of this family is unknown.. 
+PF06165 Glycosyltransferase family 36<br>Pfam-B_9110 (release 9.0). The glycosyltransferase family 36 includes cellobiose phosphorylase  (EC:2.4.1.20), cellodextrin phosphorylase (EC:2.4.1.49), chitobiose  phosphorylase (EC:2.4.1.-).  Many members of this family contain two copies of this domain.. 
+PF06166 Protein of unknown function (DUF979)<br>Pfam-B_10323 (release 9.0). This family consists of several putative bacterial membrane proteins. The function of this family is unclear.. 
+PF06167 DUF980; MtfA;<br>Glucose-regulated metallo-peptidase M90. Pfam-B_8651 (release 9.0). MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity  . The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase  , whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.. 
+PF06168 Protein of unknown function (DUF981)<br>Pfam-B_8691 (release 9.0). Family of uncharacterised proteins found in bacteria and archaea.. 
+PF06169 Protein of unknown function (DUF982)<br>Moxon SJ, Eberhardt R. Pfam-B_10431 (release 9.0). This family consists of several hypothetical proteins from Rhizobium meliloti, Rhizobium loti and Agrobacterium tumefaciens. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF06170 Protein of unknown function (DUF983)<br>Pfam-B_10629 (release 9.0). This family consists of several bacterial proteins of unknown function.. 
+PF06172 DUF985; <br>Cupin superfamily (DUF985). Pfam-B_9217 (release 9.0). Family of uncharacterised proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.. 
+PF06173 Protein of unknown function (DUF986)<br>Pfam-B_10711 (release 9.0). This family consists of several bacterial putative membrane proteins of unknown function.. 
+PF06174 Protein of unknown function (DUF987)<br>Pfam-B_9329 (release 9.0). Family of bacterial proteins that are related to the hypothetical  protein yeeT.. 
+PF06175 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)<br>Pfam-B_10761 (release 9.0). This family consists of several bacterial tRNA-(MS IO A)-hydroxylase (MiaE) proteins. The modified nucleoside 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) is present at position 37 (3' of the anticodon) of tRNAs that read codons beginning with U except tRNA(I,V Ser) in Escherichia coli. Salmonella typhimurium 2-methylthio-cis-ribozeatin (ms2io6A) is found in tRNA, probably in the corresponding species that have ms2i6A in E. coli.  The miaE gene is absent in E. coli, a finding consistent with the absence of the hydroxylated derivative of ms2i6A in this species  .. 
+PF06176 Lipopolysaccharide core biosynthesis protein (WaaY)<br>Pfam-B_10767 (release 9.0). This family consists of several bacterial lipopolysaccharide core biosynthesis proteins (WaaY or RfaY). The waaY, waaQ, and waaP genes are located in the central operon of the waa (formerly rfa) locus on the chromosome of Escherichia coli. This locus contains genes whose products are involved in the assembly of the core region of the lipopolysaccharide molecule. WaaY is the enzyme that phosphorylates HepII in this system  .. 
+PF06177 DUF988; <br>Pfam-B_10800 (release 9.0). This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes [1-2], suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.. 
+PF06178 Oligogalacturonate-specific porin protein (KdgM)<br>Pfam-B_10852 (release 9.0). This family consists of several bacterial proteins which are homologous to the oligogalacturonate-specific porin protein KdgM (Swiss:Q934G3) from Erwinia chrysanthemi. The phytopathogenic Gram-negative bacteria Erwinia chrysanthemi secretes pectinases, which are able to degrade the pectic polymers of plant cell walls, and uses the degradation products as a carbon source for growth. KdgM is a major outer membrane protein, whose synthesis is strongly induced in the presence of pectic derivatives. KdgM behaves like a voltage-dependent porin that is slightly selective for anions and that exhibits fast block in the presence of trigalacturonate. In contrast to most porins, KdgM seems to be monomeric  .  . 
+PF06179 SURF5; <br>Surfeit locus protein 5 subunit 22 of Mediator complex. Pfam-B_10889 (release 9.0). This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1.  The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organisation is similar in human, mouse and chicken Surfeit locus.  The Med22 subunit of Mediator complex is part of the essential core head region    .. 
+PF06180 Cobalt chelatase (CbiK)<br>Pfam-B_10975 (release 9.0). This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).. 
+PF06181 Protein of unknown function (DUF989)<br>Pfam-B_11062 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function. The haem-binding domain towards the C-terminus has been merged into Cytochrome_C, Pfam:PF00034.. 
+PF06182 DUF990;<br>ABC-2 family transporter protein. Moxon SJ, Eberhardt R. Pfam-B_11079 (release 9.0). This family acts as the transmembrane domain (TMD) of ABC transporters [1,2]. The family includes proteins responsible for the transport of herbicides  .. 
+PF06183 DinI-like family<br>Pfam-B_3085 (release 9.0). This family of short proteins includes DNA-damage-inducible protein I (DinI) and related proteins. The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co- protease activity of RecA. Escherichia coli DinI, a LexA-regulated SOS gene product, shuts off the initiation of the SOS response when overexpressed in vivo. Biochemical and genetic studies indicated that DinI physically interacts with RecA to inhibit its co-protease activity  . The structure of DinI is known  .. 
+PF06184 Potexvirus coat protein<br>Pfam-B_11093 (release 9.0). This family consists of several Potexvirus coat proteins.. 
+PF06185 DUF991; <br>Pfam-B_11108 (release 9.0). This family consists of several bacterial YecM proteins of unknown function.. 
+PF06186 Protein of unknown function (DUF992)<br>Pfam-B_11128 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06187 Protein of unknown function (DUF993)<br>Pfam-B_11260 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06188 HrpE/YscL/FliH and V-type ATPase subunit E<br>Pfam-B_11055 (release 9.0). This is a prokaryotic family that contains proteins of the FliH and HrpE/YscL family.\.   These proteins are involved in type III secretion, which is the process that drives flagellar biosynthesis and mediates bacterial-eukaryotic interactions [1-2].  This family also V-type ATPase subunit E.     This subunit appears to form a tight interaction with subunit G in the F0 complex  . Subunits E and G may act together as stators to prevent certain subunits from rotating with the central rotary element  .  Pfam:PF01991 also contains V-type ATPase subunit E proteins.. 
+PF06189 5'-nucleotidase<br>Pfam-B_10008 (release 9.0). This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).. 
+PF06191 Protein of unknown function (DUF995)<br>Pfam-B_11307 (release 9.0). Family of uncharacterised Proteobacteria proteins.. 
+PF06193 Orthopoxvirus A5L protein-like<br>Pfam-B_10342 (release 9.0). This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion  .. 
+PF06194 Phage Conserved Open Reading Frame 51<br>Pfam-B_11352 (release 9.0). Family of conserved bacteriophage open reading frames.. 
+PF06195 Protein of unknown function (DUF996)<br>Pfam-B_11375 (release 9.0). Family of uncharacterised bacterial and archaeal proteins.. 
+PF06196 Protein of unknown function (DUF997)<br>Pfam-B_11382 (release 9.0). Family of predicted bacterial membrane protein with unknown function.. 
+PF06197 Protein of unknown function (DUF998)<br>Pfam-B_11425 (release 9.0). Family of conserved archaeal proteins.. 
+PF06198 Protein of unknown function (DUF999)<br>Pfam-B_11426 (release 9.0). Family of conserved Schizosaccharomyces pombe proteins with  unknown function.. 
+PF06199 Phage major tail protein 2<br>Pfam-B_11427 (release 9.0). Characterised members are major tail proteins from various phage, including lactococcal temperate bacteriophage TP901-1.. 
+PF06200 Zim; <br>Pfam-B_3326 (release 9.0). This short possible domain is found in a variety of plant transcription factors that contain GATA domains as well as other motifs. Although previously known as the Zim domain this is now called the tify domain after its most conserved amino acids. TIFY proteins can be further classified into two groups depending on the presence (group I) or absence (group II) of a C2C2-GATA domain. Functional annotation of these proteins is still poor, but several screens revealed a link between TIFY proteins of group II and jasmonic acid-related stress response.. 
+PF06201 DUF1000; Thioredox_dimer;<br>This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.. 
+PF06202 Amylo-alpha-1,6-glucosidase <br>Pfam-B_3607 (release 9.0). This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homologue Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).. 
+PF06203 CCT motif<br>Pfam-B_314 (release 9.0). This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1  . The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif  . Toc1 mutants have been identified in this region.. 
+PF06204 Putative carbohydrate binding domain  <br>Pfam-B_9110 (release 9.0). 
+PF06205 Glycosyltransferase 36 associated family  <br>Pfam-B_9110 (release 9.0). 
+PF06206 DUF1001; <br>CpeT/CpcT family (DUF1001). Pfam-B_11004 (release 9.0). This family consists of proteins of proteins belonging to the CpeT/CpcT family. These proteins are around 200 amino acids in length.  The proteins contain a conserved motif PYR in the amino terminal half of the protein that may be functionally important. The species distribution of the family is interesting.  So far it is restricted to cyanobacteria, cryptomonads and plants. It has been shown that CpcT encodes a bilin lyase responsible for attachment of phycocyanobilin to the beta subunit of phycocyanin  .. 
+PF06207 Protein of unknown function (DUF1002)<br>Pfam-B_10868 (release 9.0). This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.. 
+PF06208 Borna disease virus G protein<br>Pfam-B_10516 (release 9.0). This family consists of Borna disease virus G glycoprotein sequences. Borna disease virus (BDV) infection produces a variety of clinical diseases, from behavioural illnesses to classical fatal encephalitis  . G protein is important for viral entry into the host cell [2,3].. 
+PF06209 Cofactor of BRCA1 (COBRA1)<br>Pfam-B_11228 (release 9.0). This family consists of several cofactor of BRCA1 (COBRA1) like proteins. It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfolding. BRCA1 mutations that enhance chromatin unfolding also increase its affinity for, and recruitment of, COBRA1. It is thought that that reorganisation of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions  .. 
+PF06210 Protein of unknown function (DUF1003)<br>Pfam-B_10814 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06211 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain<br>Pfam-B_11792 (release 9.0). This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling  .. 
+PF06212 GRIM-19 protein<br>Pfam-B_10760 (release 9.0). This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-ß and RA. A bovine homologue of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localisation and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity  . . 
+PF06213 Cobalamin biosynthesis protein CobT<br>Pfam-B_10956 (release 9.0). This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid  . . 
+PF06214 Signaling lymphocytic activation molecule (SLAM) protein<br>Pfam-B_11112 (release 9.0). This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones  . SLAM has also been recognised as a receptor for measles virus  .. 
+PF06215 Infectious salmon anaemia virus haemagglutinin<br>Pfam-B_11275 (release 9.0). This family consists of several infectious salmon anaemia virus haemagglutinin proteins. Infectious salmon anaemia virus (ISAV), an orthomyxovirus-like virus, is an important fish pathogen in marine aquaculture  .  . 
+PF06216 Rice tungro bacilliform virus P46 protein<br>Pfam-B_11281 (release 9.0). This family consists of several Rice tungro bacilliform virus P46 proteins. The function of this family is unknown.. 
+PF06217 DUF1004; <br>GAGA binding protein-like family. Pfam-B_10604 (release 9.0). This family includes gbp a protein from Soybean that binds to GAGA element dinucleotide repeat DNA  . It seems likely that the this domain mediates DNA binding. This putative domain contains several conserved cysteines and a histidine suggesting this may be a zinc-binding DNA interaction domain.. 
+PF06218 Nitrogen permease regulator 2<br>Pfam-B_11335 (release 9.0). This family of regulators are involved in post-translational control  of  nitrogen permease.. 
+PF06219 Protein of unknown function (DUF1005)<br>Pfam-B_11366 (release 9.0). Family of plant proteins with undetermined function.. 
+PF06220 zf-U1; U1_C; <br>Pfam-B_10606 (release 9.0). This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly.  Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilise U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator  . This domain is probably a zinc-binding.  It is found in multiple copies in some members of the family.. 
+PF06221 Zf-C2HC5; <br>Putative zinc finger motif, C2HC5-type. Pfam-B_11300 (release 9.0). This zinc finger appears to be common in activating signal  cointegrator 1/thyroid receptor interacting protein 4.. 
+PF06222 Phage tail assembly chaperone<br>Pfam-B_11379 (release 9.0). 
+PF06223 Minor tail protein T<br>Pfam-B_8084 (release 9.0). Minor tail protein T is located at the distal end and is involved in the assembly of the initiator complex for tail polymerisation  .. 
+PF06224 DUF1006;<br>Winged helix DNA-binding domain. Pfam-B_8424 (release 9.0). This family contains two copies of a winged helix domain.. 
+PF06226 Protein of unknown function (DUF1007)<br>Pfam-B_8585 (release 9.0). Family of conserved bacterial proteins with unknown function.. 
+PF06227 Orthopox_N1;<br>Pfam-B_10619 (release 9.0). This is a family of dsDNA viruses, with no RNA stage, Poxvirus proteins.. 
+PF06228 DUF1008;<br>Haem utilisation ChuX/HutX. Pfam-B_10620 (release 9.0). This family is found within haem utilisation operons. It has a similar structure to that of Pfam:PF05171. Pfam:PF05171 usually occurs as a duplicated domain, but this domain occurs as a single domain and forms a dimer. The organisation of the dimer is very similar to that of the duplicated Pfam:PF05171 domains [1,2]. It binds haem via conserved histidines  .. 
+PF06229 FRG1-like family<br>Pfam-B_8590 (release 9.0). The human FRG1 gene maps to human chromosome 4q35 and has been identified   as a candidate for facioscapulohumeral muscular dystrophy.  Currently, the function of FRG1 is unknown  .. 
+PF06230 Protein of unknown function (DUF1009)<br>Pfam-B_8705 (release 9.0). Family of uncharacterised bacterial proteins.. 
+PF06231 Protein of unknown function (DUF1010)<br>Pfam-B_11467 (release 9.0). Family of plasmid encoded proteins with unknown function.. 
+PF06232 Embryo-specific protein 3, (ATS3)<br>Pfam-B_11504 (release 9.0). Family of plant seed-specific proteins.. 
+PF06233 Usg-like family<br>Pfam-B_11528 (release 9.0). Family of bacterial proteins, referred to as Usg. Usg is found in the same operon as trpF, trpB, and trpA and is expressed in a coupled transcription-translation system  .. 
+PF06234 Toluene-4-monooxygenase system protein B (TmoB)<br>Moxon SJ, Iyer LM, Burroughs AM, Aravind L. Pfam-B_10626 (release 9.0). This family consists of several Toluene-4-monooxygenase system protein B (TmoB) sequences. Pseudomonas mendocina KR1 metabolises toluene as a carbon source. The initial step of the pathway is hydroxylation of toluene to form p-cresol by a multicomponent toluene-4-monooxygenase (T4MO) system  . TmoB adopts a ubiquitin fold  . Although TmoB is a component of the T4MO system, its  precise role remains unclear.. 
+PF06235 NADH dehydrogenase subunit 4L (NAD4L)<br>Pfam-B_10667 (release 9.0). This family consists of NADH dehydrogenase subunit 4L (NAD4L) proteins from the mitochondria of several parasitic flatworms.. 
+PF06236 Tyrosinase co-factor MelC1<br>Pfam-B_10673 (release 9.0). This family consists of several tyrosinase co-factor MELC1 proteins from a number of Streptomyces species. The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase MelC2 to facilitate the incorporation of copper ion and the secretion of tyrosinase indicating that MelC1 is a chaperone for the apotyrosinase MelC2  .. 
+PF06237 Protein of unknown function (DUF1011)<br>Pfam-B_11463 (release 9.0). Family of uncharacterised eukaryotic proteins.. 
+PF06238 Borrelia_lipopr; <br>Borrelia burgdorferi BBR25 lipoprotein. Pfam-B_15000 (release 9.0). This family consists of a number of lipoproteins from the Lyme disease spirochete Borrelia burgdorferi  .. 
+PF06239 Evolutionarily conserved signalling intermediate in Toll pathway<br>Pfam-B_9306 (release 9.0). Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1  .. 
+PF06240 CoxG; <br>Carbon monoxide dehydrogenase subunit G (CoxG). Pfam-B_9339 (release 9.0). The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source  .. 
+PF06241 Protein of unknown function (DUF1012)<br>Pfam-B_9320 (release 9.0). Family of uncharacterised proteins found in both eukaryotes and bacteria.. 
+PF06242 Protein of unknown function (DUF1013)<br>Pfam-B_9390 (release 9.0). Family of uncharacterised proteins found in Proteobacteria.. 
+PF06243 Phenylacetic acid degradation B<br>Pfam-B_9426 (release 9.0). Phenylacetic acid degradation protein B (PaaB) is thought to be part of  a multicomponent oxygenase involved in  phenylacetyl-CoA hydroxylation  .. 
+PF06244 Protein of unknown function (DUF1014)<br>Moxon SJ, Coggill PC. Pfam-B_11009 (release 9.0). This family consists of several hypothetical eukaryotic proteins of unknown function.. 
+PF06245 Protein of unknown function (DUF1015)<br>Pfam-B_9451 (release 9.0). Family of proteins with unknown function found in archaea and bacteria.. 
+PF06246 Isy1-like splicing family<br>Pfam-B_9462 (release 9.0). Isy1 protein is important in the optimisation of splicing  .. 
+PF06247 Plasmodium ookinete surface protein Pvs28<br>Pfam-B_11346 (release 9.0). This family consists of several ookinete surface protein (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals  .. 
+PF06248 Centromere/kinetochore Zw10<br>Pfam-B_9476 (release 9.0). Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis [1,2]. These proteins bind to the centromere/kinetochore  .. 
+PF06249 Ethanolamine utilisation protein EutQ<br>Pfam-B_11530 (release 9.0). The eut operon of Salmonella typhimurium encodes proteins involved in the cobalamin-dependent degradation of ethanolamine. The role of EutQ in this process is unclear  .. 
+PF06250 Protein of unknown function (DUF1016)<br>Pfam-B_9571 (release 9.0). Family of uncharacterised proteins found in viruses, archaea and bacteria.. 
+PF06251 DUF1017;<br>Capsule biosynthesis GfcC. Pfam-B_9574 (release 9.0). Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation  .  This family plays a role in group 4 capsule biosynthesis  .  These proteins have a beta-grasp fold  . Two beta-grasp domains, D2 and D3, are arranged in tandem. There is a C-terminal amphipathic helix which packs against D3. A helical hairpin insert in D2 binds to D3 and constrains its position, a conserved arginine residue at the end of this hairpin is essential for structural integrity  .. 
+PF06252 Protein of unknown function (DUF1018)<br>Pfam-B_11125 (release 9.0). This family consists of several bacterial and phage proteins of unknown function.. 
+PF06253 Trimethylamine methyltransferase (MTTB)<br>Pfam-B_11132 (release 9.0). This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.. 
+PF06254 Protein of unknown function (DUF1019)<br>Pfam-B_9681 (release 9.0). Family of uncharacterised proteins found in Proteobacteria.. 
+PF06255 Protein of unknown function (DUF1020)<br>Pfam-B_11136 (release 9.0). This family consists of several MafB proteins from Neisseria meningitidis and Neisseria gonorrhoeae. The function of this family is unknown.. 
+PF06256 Nucleopolyhedrovirus LEF-12 protein<br>Pfam-B_11198 (release 9.0). This family consists of several Nucleopolyhedrovirus late expression factor-12 (LEF-12) proteins. The function of this family is unknown [1,2].. 
+PF06257 Protein of unknown function (DUF1021)<br>Pfam-B_11556 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06258 DUF1022;<br>Mitochondrial fission ELM1. Moxon SJ, Eberhardt R. Pfam-B_10595 (release 9.0). In plants, this family is involved in mitochondrial fission. It binds to dynamin-related proteins and plays a role in their relocation from the cytosol to mitochondrial fission sites  . Its function in bacteria is unknown.. 
+PF06259 DUF1023;<br>Alpha/beta hydrolase. Pfam-B_9720 (release 9.0). Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile  .. 
+PF06260 Protein of unknown function (DUF1024)<br>Pfam-B_11584 (release 9.0). This family consists of several hypothetical Staphylococcus aureus and Staphylococcus aureus phage phi proteins. The function of this family is unknown.. 
+PF06261 Actinobacillus actinomycetemcomitans leukotoxin activator LktC<br>Pfam-B_11552 (release 9.0). This family consists of several Actinobacillus actinomycetemcomitans leukotoxin activator (LktC) proteins. Actinobacillus actinomycetemcomitans is a Gram-negative bacterium that has been implicated in the etiology of several forms of periodontitis, especially localised juvenile periodontitis. LktC along with LktB and LktD are thought to be required for activation and localisation of the leukotoxin  .  . 
+PF06262 Possibl zinc metallo-peptidase<br>Pfam-B_9726 (release 9.0). This is possibly a family of bacterial zinc metallo-peptidases. Although they carry the HExxHxxGxxD motif, they are missing a final methionine which would class them as Met-zincins.. 
+PF06265 Protein of unknown function (DUF1027)<br>Pfam-B_11526 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06266 HrpF protein<br>Pfam-B_11646 (release 9.0). The species Pseudomonas syringae encompasses plant pathogens with differing host specificities and corresponding pathovar designations. P. syringae requires the Hrp (type III protein secretion) system, encoded by a 25-kb cluster of hrp and hrc genes, in order to elicit the hypersensitive response (HR) in nonhosts or to be pathogenic in hosts. The exact function of HrpF is unknown but the protein is needed for pathogenicity  .. 
+PF06267 Family of unknown function (DUF1028)<br>Pfam-B_9747 (release 9.0). Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolism.. 
+PF06268 Fascin domain<br>Pfam-B_11660 (release 9.0). This family consists of several eukaryotic fascin or singed proteins.  The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture  .\.       Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerisation and binding to microfilaments only at pH values below seven  .  Members of this family are histidine rich, typically contain the repeated motif of HHXH  .. 
+PF06269 Protein of unknown function (DUF1029)<br>Pfam-B_11672 (release 9.0). This family consists of several short Chordopoxvirus proteins of unknown function.. 
+PF06270 Protein of unknown function (DUF1030)<br>Pfam-B_11673 (release 9.0). This family consists of several short Circovirus proteins of unknown function.. 
+PF06271 RDD family<br>Pfam-B_1111 (release 9.0). 
+PF06273 Plant_eIF4B; <br>Plant specific eukaryotic initiation factor 4B. Pfam-B_11679 (release 9.0). This family consists of several plant specific eukaryotic initiation factor 4B proteins.. 
+PF06275 Protein of unknown function (DUF1031)<br>Pfam-B_11618 (release 9.0). This family consists of several Lactococcus lactis bacteriophage and Lactococcus lactis proteins of unknown function.. 
+PF06276 Ferric iron reductase FhuF-like transporter<br>Pfam-B_11690 (release 9.0). This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.\.      FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B  .  This family also includes the IucA and IucC proteins.. 
+PF06277 Ethanolamine utilisation protein EutA<br>Pfam-B_11716 (release 9.0). This family consists of several bacterial EutA ethanolamine utilisation proteins. The EutA protein is thought to protect the lyase (EutBC) from inhibition by CNB12  .. 
+PF06278 Protein of unknown function (DUF1032)<br>Pfam-B_11729 (release 9.0). This family consists of several conserved eukaryotic proteins of unknown function.. 
+PF06279 Protein of unknown function (DUF1033)<br>Pfam-B_11732 (release 9.0). This family consists of several hypothetical bacterial proteins. Many of the sequences in this family are annotated as putative DNA binding proteins but the function of this family is unknown.. 
+PF06280 Fn3-like domain (DUF1034)<br>This family consists of several domains of unknown function which are present in several bacterial and plant peptidases. This domain is found in conjunction with Pfam:PF00082, Pfam:PF02225 and is often found with Pfam:PF00746. This domain has a structure similar to an Fn3 domain  .. 
+PF06281 Protein of unknown function (DUF1035)<br>Pfam-B_11733 (release 9.0). This family consists of several Sulfolobus and Sulfolobus virus proteins of unknown function.. 
+PF06282 Protein of unknown function (DUF1036)<br>Pfam-B_11760 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06283 DUF1037; <br>Trehalose utilisation. Pfam-B_11803 (release 9.0). This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose  . The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium  .. 
+PF06284 Cytomegalo_UL84; <br>Cytomegalovirus UL84 protein. Pfam-B_11948 (release 9.0). This family consists of several Cytomegalovirus UL84 proteins. The open reading frame UL84 of human cytomegalovirus encodes a multifunctional regulatory protein which is required for viral DNA replication and binds with high affinity to the immediate-early transactivator IE2-p86  .. 
+PF06286 Coleoptericin<br>Pfam-B_11996 (release 9.0). This family consists of several insect Coleoptericin, Acaloleptin, Holotricin and Rhinocerosin proteins which are all known to be antibacterial proteins  .. 
+PF06287 Protein of unknown function (DUF1039)<br>Pfam-B_12079 (release 9.0). This family consists of several hypothetical bacterial proteins from Escherichia coli and Citrobacter rodentium. The function of this family is unknown.. 
+PF06288 Protein of unknown function (DUF1040)<br>Pfam-B_12122 (release 9.0). This family consists of several bacterial YihD proteins of unknown function  .  . 
+PF06289 Flagellar protein (FlbD)<br>Pfam-B_12586 (release 9.0). This family consists of several bacterial FlbD flagellar proteins. The exact function of this family is unknown  .. 
+PF06290 Plasmid SOS inhibition protein (PsiB)<br>Pfam-B_12789 (release 9.0). This family consists of several plasmid SOS inhibition protein (PsiB) sequences  .. 
+PF06291 Bor protein<br>Pfam-B_12850 (release 9.0). This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the Escherichia coli host cell in animal serum. This property is a well known bacterial virulence determinant indeed, bor and its adjacent sequences are highly homologous to the iss serum resistance locus of the plasmid ColV2-K94, which confers virulence in animals. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis  .. 
+PF06292 Domain of Unknown Function (DUF1041)<br>This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with Pfam:PF00168, Pfam:PF00130 and Pfam:PF00169 domains.. 
+PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family<br>Krupa A, Srinivasan N. These lipopolysaccharide kinases are related to protein kinases Pfam:PF00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is  necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica  .. 
+PF06294 Domain of Unknown Function (DUF1042)<br>Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum  . The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear  . Transcription aberrations leading to a truncated protein result in immotile sperm  .. 
+PF06295 Protein of unknown function (DUF1043)<br>Pfam-B_12007 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06296 Protein of unknown function (DUF1044)<br>Pfam-B_12045 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06297 PET Domain<br>This domain is suggested to be involved in protein-protein interactions  . The family is found in conjunction with Pfam:PF00412.. 
+PF06298 Photosystem II protein Y (PsbY)<br>Pfam-B_12212 (release 9.0). This family consists of several bacterial and plant photosystem II protein Y (PsbY) sequences. PsbY is a manganese-binding protein that has an L-arginine metabolising enzyme activity  .. 
+PF06299 Protein of unknown function (DUF1045)<br>Pfam-B_12127 (release 9.0). This family consists of several hypothetical proteins from Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.. 
+PF06300 Tsp45I type II restriction enzyme<br>Pfam-B_12151 (release 9.0). This family consists of several type II restriction enzymes.. 
+PF06301 Bacteriophage lambda Kil protein<br>Pfam-B_12201 (release 9.0). This family consists of several Bacteriophage lambda Kil protein like sequences from both phages and bacteria. Induction of a lambda prophage causes the death of the host cell even in the absence of phage replication and lytic functions due to expression of the lambda kil gene  .. 
+PF06303 DUF1047; <br>Organiser of macrodomain of Terminus of chromosome. Pfam-B_12243 (release 9.0). This family, many of whose members are YcbG, organises the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. Organisation of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localises with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organiser of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organisational system is required in the Terminus region for bacterial chromosome management during the cell cycle.. 
+PF06304 Protein of unknown function (DUF1048)<br>Pfam-B_12247 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06305 Protein of unknown function (DUF1049)<br>Pfam-B_12262 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06306 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA)<br>Pfam-B_12320 (release 9.0). This family consists of several beta-1,4-N-acetylgalactosaminyltransferase proteins from Campylobacter jejuni  .. 
+PF06307 Herpesvirus IR6 protein<br>Pfam-B_12322 (release 9.0). This family consists of several Herpesvirus IR6 proteins. The equine herpesvirus 1 (EHV-1) IR6 protein forms typical rod-like structures in infected cells, influences virus growth at elevated temperatures, and determines the virulence of EHV-1 Rac strains  .. 
+PF06308 23S rRNA methylase leader peptide (ErmC)<br>Pfam-B_12332 (release 9.0). This family consists of several very short bacterial 23S rRNA methylase leader peptide (ErmC) sequences. ermC confers resistance to macrolide-lincosamide streptogramin B antibiotics by specifying a ribosomal RNA methylase, which results in decreased ribosomal affinity for these antibiotics. ermC expression is induced by exposure to erythromycin  .  . 
+PF06311 NUMB domain<br>This presumed domain is found in the Numb family of proteins adjacent to the PTB domain... 
+PF06312 Neurexophilin<br>Pfam-B_12369 (release 9.0). This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins  . . 
+PF06309 Torsin<br>Pfam-B_12047 (release 9.0). This family consists of several eukaryotic torsin proteins. Torsion dystonia is an autosomal dominant movement disorder characterised by involuntary, repetitive muscle contractions and twisted postures. The most severe early-onset form of dystonia has been linked to mutations in the human DYT1 (TOR1A) gene encoding a protein termed torsinA. While causative genetic alterations have been identified, the function of torsin proteins and the molecular mechanism underlying dystonia remain unknown. Phylogenetic analysis of the torsin protein family indicates these proteins share distant sequence similarity with the large and diverse family of (Pfam:PF00004) proteins. It has been suggested that torsins play a role in effectively managing protein folding and that possible breakdown in a neuroprotective mechanism that is, in part, mediated by torsins may be responsible for the neuronal dysfunction associated with dystonia  .. 
+PF06313 Drosophila ACP53EA protein<br>Pfam-B_12718 (release 9.0). This family consists of several Drosophila ACP53EA accessory gland (seminal) proteins.. 
+PF06314 Acetoacetate decarboxylase (ADC)<br>Pfam-B_12720 (release 9.0). This family consists of several acetoacetate decarboxylase (ADC) proteins (EC:4.1.1.4).. 
+PF06315 Isocitrate dehydrogenase kinase/phosphatase (AceK)<br>Pfam-B_13100 (release 9.0). This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (AceK) proteins (EC:2.7.1.116)  .. 
+PF06316 Enterobacterial Ail/Lom protein<br>Pfam-B_12325 (release 9.0). This family consists of several bacterial and phage Ail/Lom-like proteins. The Yersinia enterocolitica Ail protein is a known virulence factor. Proteins in this family are predicted to consist of eight transmembrane beta-sheets and four cell surface-exposed loops. It is thought that Ail directly promotes invasion and loop 2 contains an active site, perhaps a receptor-binding domain  .  The phage protein Lom is expressed during lysogeny, and encode host-cell envelope proteins. Lom is found in the bacterial outer membrane, and is homologous to virulence proteins of two other enterobacterial genera. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis  .. 
+PF06317 Arenavirus RNA polymerase<br>Pfam-B_12490 (release 9.0). This family consists of several Arenavirus RNA polymerase proteins (EC:2.7.7.48)  .. 
+PF06319 Protein of unknown function (DUF1052)<br>Pfam-B_12539 (release 9.0). This family consists of several bacterial proteins of unknown function.. 
+PF06320 GCN5-like protein 1 (GCN5L1)<br>Pfam-B_12526 (release 9.0). This family consists of several eukaryotic GCN5-like protein 1 (GCN5L1) sequences. The function of this family is unknown [1,2].. 
+PF06321 Major fimbrial subunit protein (FimA)<br>Pfam-B_13339 (release 9.0). This family consists of several Porphyromonas gingivalis major fimbrial subunit protein (FimA) sequences. Fimbriae of Porphyromonas gingivalis, a periodontopathogen, play an important role in its adhesion to and invasion of host cells. The fimA genes encoding fimbrillin (FimA), a subunit protein of fimbriae, have been classified into five types, types I to V, based on nucleotide sequences. It has been found that type II FimA can bind to epithelial cells most efficiently through specific host receptors  . Human dental plaque is a multispecies microbial biofilm that is associated with two common oral diseases, dental caries and periodontal disease.  There is an inter-species contact-dependent communication system between P. gingivalis and S. cristatus that involces the Arc-A enzyme  .. 
+PF06322 Phage NinH protein<br>Pfam-B_12973 (release 9.0). This family consists of several phage NinH proteins. The function of this family is unknown.. 
+PF06323 Phage antitermination protein Q<br>Pfam-B_12730 (release 9.0). This family consists of several phage antitermination protein Q and related bacterial sequences. Phage 82 gene Q encodes a phage-specific positive regulator of late gene expression, thought, by analogy to the corresponding gene of phage lambda, to be a transcription antiterminator  .  . 
+PF06324 Pigment-dispersing hormone (PDH)<br>Pfam-B_12230 (release 9.0). This family consists of several eukaryotic pigment-dispersing hormone (PDH) proteins. The pigment-dispersing hormone (PDH) is produced in the eyestalks of Crustacea where it induces light-adapting movements of pigment in the compound eye and regulates the pigment dispersion in the chromatophores  .. 
+PF06325 Ribosomal protein L11 methyltransferase (PrmA)<br>Pfam-B_12272 (release 9.0). This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.. 
+PF06326 Vesiculovirus matrix protein<br>Pfam-B_13088 (release 9.0). This family consists of several Vesiculovirus matrix proteins. The matrix (M) protein of vesicular stomatitis virus (VSV) expressed in the absence of other viral components causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein  .. 
+PF06327 Domain of Unknown Function (DUF1053)<br>This domain is found in Adenylate cyclases.. 
+PF06328 Ig-like C2-type domain<br>This domain is a ligand-binding immunoglobulin-like domain  . The two cysteine residues form a disulphide bridge.. 
+PF06330 Trichodiene synthase (TRI5)<br>Pfam-B_13220 (release 9.0). This family consists of several fungal trichodiene synthase proteins (EC:4.2.3.6). TRI5 encodes the enzyme trichodiene synthase, which has been shown to catalyse the first step in the trichothecene pathways of Fusarium and Trichothecium species [1,2]. . 
+PF06331 REX1; <br>Transcription factor TFIIH complex subunit Tfb5. This family is a component of the general transcription and DNA repair factor IIH.  TFB5 has been shown to be required for efficient recruitment of TFIIH to a promoter  .. 
+PF06333 TRAP240; TRAP_240kDa; Med13; <br>Mediator complex subunit 13 C-terminal. Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood  .. 
+PF06334 Orthopoxvirus A47 protein<br>Pfam-B_13263 (release 9.0). This family consists of several Orthopoxvirus A47 proteins. The function of this family is unknown.. 
+PF06335 Protein of unknown function (DUF1054)<br>Pfam-B_13269 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06336 Coronavirus 5a protein<br>Pfam-B_13277 (release 9.0). This family consists of several Coronavirus 5a proteins. The function of this family is unknown  .. 
+PF06337 DUF1055;<br>The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved  . Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet  .. 
+PF06338 ComK protein<br>Pfam-B_13324 (release 9.0). This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level  .. 
+PF06339 Ectoine synthase<br>Pfam-B_14542 (release 9.0). This family consists of several bacterial ectoine synthase proteins. The ectABC genes encode the diaminobutyric acid acetyltransferase (EctA), the diaminobutyric acid aminotransferase (EctB), and the ectoine synthase (EctC). Together these proteins constitute the ectoine biosynthetic pathway  .. 
+PF06340 Vibrio cholerae toxin co-regulated pilus biosynthesis protein F<br>Pfam-B_13058 (release 9.0). This family consists of several Vibrio cholerae toxin co-regulated pilus biosynthesis protein F (TcpF) sequences. TcpF is known to be a secreted virulence protein but its exact function is unknown  .. 
+PF06341 Protein of unknown function (DUF1056)<br>Pfam-B_13260 (release 9.0). This family consists of several putative head-tail joining bacteriophage proteins.. 
+PF06342 Alpha/beta hydrolase of unknown function (DUF1057)<br>Pfam-B_13294 (release 9.0). This family consists of several Caenorhabditis elegans specific proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.. 
+PF06344 VPG_P3B; <br>Parechovirus Genome-linked protein. This family is of the Parechovirus genome-linked protein Vpg type P3B.. 
+PF06345 DRF Autoregulatory Domain<br>This motif is found in Diaphanous-related formins. It binds the N-terminal GTPase-binding domain; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of DAD to mammalian cells induces actin filament formation, stabilises microtubules,  and activates serum-response mediated transcription ( ).. 
+PF06346 Formin Homology Region 1<br>This region is found in some of the Diaphanous related formins (Drfs) ( ). It consists of low complexity repeats of around 12 residues.. 
+PF06347 Bacterial SH3 domain<br>Pfam-B_13248 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function. These are composed of SH3-like domains.. 
+PF06348 Protein of unknown function (DUF1059)<br>Pfam-B_13303 (release 9.0). This family consists of several short hypothetical archaeal proteins of unknown function.. 
+PF06350 HSL; <br>Hormone-sensitive lipase (HSL) N-terminus. Pfam-B_13329 (release 9.0). This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin  .. 
+PF06351 Allene oxide cyclase<br>Pfam-B_13374 (release 9.0). This family consists of several plant specific allene oxide cyclase proteins (EC:5.3.99.6). The allene oxide cyclase (AOC)-catalysed step in jasmonate (JA) biosynthesis is important in the wound response of tomato  .  . 
+PF06353 Protein of unknown function (DUF1062)<br>Pfam-B_13377 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06355 Aegerolysin<br>Pfam-B_13415 (release 9.0). This family consists of several bacterial and eukaryotic Aegerolysin-like proteins. It has been found that aegerolysin and ostreolysin are expressed during formation of primordia and fruiting bodies. It has been suggested that these haemolysins play an important role in initial phase of fungal fruiting. The bacterial members of this family are expressed during sporulation  .  Ostreolysin was found cytolytic to various erythrocytes and tumour cells  . It forms transmembrane pores 4 nm in diameter. The activity is inhibited by total membrane lipids, and modulated by lysophosphatides. The potential use of aegerolysins is reviewed   with special emphasis on their properties which would allow thier use in therapeutics.. 
+PF06356 Protein of unknown function (DUF1064)<br>Pfam-B_13437 (release 9.0). This family consists of several phage and bacterial proteins of unknown function.. 
+PF06357 Omega-atracotox;<br>Pfam-B_14633 (release 9.0). This family consists of several Hadronyche versuta (Blue mountains funnel-web spider) specific omega-atracotoxin proteins. Omega-Atracotoxin-Hv1a is an insect-specific neurotoxin whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels  . . 
+PF06358 Protein of unknown function (DUF1065)<br>Pfam-B_14830 (release 9.0). This family consists of several Benyvirus proteins of unknown function.. 
+PF06360 Euplotes raikovi mating pheromone<br>Pfam-B_14708 (release 9.0). This family consists of several Euplotes raikovi mating pheromone proteins. Diffusible polypeptide pheromones, which distinguish otherwise morphologically identical vegetative cell types from one another, are produced by some species of ciliates. In the marine sand-dwelling protozoan ciliate Euplotes raikovi, pheromone molecules promote the vegetative reproduction (mitogenic proliferation or growth) of the same cells from which they originate. As, understandably, such autocrine pheromone activity is primary to that of targeting and inducing a foreign cell to mate (paracrine functions), this finding provides an example of how the original function of a molecule can be obscured during evolution by the acquisition of a new one  .. 
+PF06361 Rice tungro bacilliform virus P12 protein<br>Pfam-B_14960 (release 9.0). This family consists of several Rice tungro bacilliform virus P12 proteins. The function of this family is unknown  .. 
+PF06362 Protein of unknown function (DUF1067)<br>Pfam-B_15074 (release 9.0). This family consists of several hypothetical Mycobacterium leprae specific proteins. The function of this family is unknown.. 
+PF06363 Picornaviridae P3A protein<br>This family consists of the P3A protein of  picornaviridae. P3A has been identified as a genome-linked protein (VPg) and is involved in replication ( ).. 
+PF06364 Protein of unknown function (DUF1068)<br>Pfam-B_14602 (release 9.0). This family consists of several hypothetical plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.. 
+PF06365 CD34/Podocalyxin family<br>Pfam-B_14609 (release 9.0) & Pfam-B_17463 (release 8.0). This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation  . This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an  anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion  .. 
+PF06366 Flagellar protein FlhE<br>Pfam-B_14631 (release 9.0). This family consists of several Enterobacterial FlhE flagellar proteins. The exact function of this family is unknown  .. 
+PF06367 Diaphanous FH3 Domain<br>This region is found in the Formin-like and and diaphanous proteins [1,2].. 
+PF06368 Methylaspartate mutase E chain (MutE)<br>Pfam-B_14693 (release 9.0). This family consists of several methylaspartate mutase E chain proteins (EC:5.4.99.1). Glutamate mutase catalyses the first step in the fermentation of glutamate by Clostridium tetanomorphum. This is an unusual isomerisation in which L-glutamate is converted to threo-beta-methyl L-aspartate  .. 
+PF06369 Sea anemone cytotoxic protein<br>Pfam-B_14701 (release 9.0). Sea anemones are a rich source of cytotoxic proteins. Cytolysins comprise a group of more than 30 highly basic proteins with molecular masses of about 20 kDa. Cytolysins isolated from the sea anemone, Heteractis magnifica, include magnificalysin I (HMg I), magnificalysin II (HMg II) and Heteractis magnifica toxin (HMgtxn). These are highly homologous at their N-terminals. HMg I and II have molecular masses of approximately 19 kDa, and pI values of 9.4 and 10.0, respectively. Cytolysins isolated from other sea anemones Actinia tenebrosa (Tenebrosin-C, TN-C), Actinia equina (Equinatoxin, EqT) and Stichodactyla helianthus (ShC) exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities  .. 
+PF06370 Protein of unknown function (DUF1069)<br>Pfam-B_14815 (release 9.0). This family consists of several Maize streak virus 21.7 kDa proteins. The function of this family is unknown.. 
+PF06371 Diaphanous GTPase-binding Domain<br>This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.. 
+PF06372 Gemin6 protein<br>Pfam-B_14816 (release 9.0). This family consists of several mammalian Gemin6 proteins. The exact function of Gemin6 is unknown but it has been found to form part of the Pfam:PF06003 complex. The SMN complex plays a key role in the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and other ribonucleoprotein particles  .. 
+PF06373 Cocaine and amphetamine regulated transcript protein (CART)<br>Pfam-B_15325 (release 9.0). This family consists of several cocaine and amphetamine regulated transcript type I protein (CART) sequences. Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots  . . 
+PF06374 NDUFC2; <br>NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2). Pfam-B_15334 (release 9.0). This family consists of several NADH-ubiquinone oxidoreductase subunit b14.5b proteins (EC:1.6.5.3).. 
+PF06375 Bovine leukaemia virus receptor (BLVR)<br>Pfam-B_14559 (release 9.0). This family consists of several bovine specific leukaemia virus receptors which are thought to function as transmembrane proteins, although their exact function is unknown  .. 
+PF06376 Protein of unknown function (DUF1070)<br>Pfam-B_14060 (release 9.0). This family consists of several short hypothetical plant proteins of unknown function.. 
+PF06377 Adipokinetic hormone<br>Pfam-B_14600 (release 9.0). This family consists of several insect adipokinetic hormone as well as the related crustacean red pigment concentrating hormone. Flight activity of insects comprises one of the most intense biochemical processes known in nature, and therefore provides an attractive model system to study the hormonal regulation of metabolism during physical exercise. In long-distance flying insects, such as the migratory locust, both carbohydrate and lipid reserves are utilised as fuels for sustained flight activity. The mobilization of these energy stores in Locusta migratoria is mediated by three structurally related adipokinetic hormones (AKHs), which are all capable of stimulating the release of both carbohydrates and lipids from the fat body  .. 
+PF06378 Protein of unknown function (DUF1071)<br>Pfam-B_14587 (release 9.0). This family consists of several hypothetical bacterial and phage proteins of unknown function.. 
+PF06379 L-rhamnose-proton symport protein (RhaT)<br>Pfam-B_14617 (release 9.0). This family consists of several bacterial L-rhamnose-proton symport protein (RhaT) sequences [1,2].. 
+PF06380 Protein of unknown function (DUF1072)<br>Pfam-B_14592 (release 9.0). This family consists of several Barley yellow dwarf virus proteins of unknown function.. 
+PF06381 Protein of unknown function (DUF1073)<br>Pfam-B_14928 (release 9.0). This family consists of several hypothetical bacterial proteins. The function of this family is unknown.. 
+PF06382 Protein of unknown function (DUF1074)<br>Pfam-B_14962 (release 9.0). This family consists of several proteins which appear to be specific to Drosophila melanogaster. The function of this family is unknown.. 
+PF06384 Beta-catenin-interacting protein ICAT<br>Pfam-B_15027 (release 9.0). This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions  .. 
+PF06385 Baculovirus LEF-11 protein<br>Pfam-B_15073 (release 9.0). This family consists of several Baculovirus LEF-11 proteins. The exact function of this family is unknown although it has been shown that LEF-11 is required for viral DNA replication during the infection cycle  .. 
+PF06386 Gas vesicle synthesis protein GvpL/GvpF<br>Pfam-B_15376 (release 9.0). This family consists of several bacterial and archaeal gas vesicle synthesis protein (GvpL/GvpF) sequences. The exact function of this family is unknown.. 
+PF06387 D1 dopamine receptor-interacting protein (calcyon)<br>Pfam-B_15400 (release 9.0). This family consists of several  D1 dopamine receptor-interacting (calcyon) proteins.  D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling  . Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD)   and schizophrenia  .. 
+PF06388 Protein of unknown function (DUF1075)<br>Pfam-B_14186 (release 9.0). This family consists of several eukaryotic proteins of unknown function.. 
+PF06389 Filovirus_VP24; <br>Filovirus membrane-associated protein VP24. Pfam-B_15734 (release 9.0). This family consists of several membrane-associated protein VP24 sequences from a variety of Ebola and Marburg viruses. The VP24 protein of Ebola virus is believed to be a secondary matrix protein and minor component of virions. VP24 possesses structural features commonly associated with viral matrix proteins and that VP24 may have a role in virus assembly and budding  .. 
+PF06390 Neuroendocrine-specific golgi protein P55 (NESP55)<br>Pfam-B_16185 (release 9.0). This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins  .. 
+PF06391 CDK-activating kinase assembly factor MAT1<br>Pfam-B_16773 (release 9.0). MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH  .  The domain found to the N-terminal side of this domain is a C3HC4 RING finger  .. 
+PF06392 Acid shock protein repeat <br>Pfam-B_20230 (release 9.0). The Asr protein is synthesised as a precursor and the cleavage is essential for moderate to high acid tolerance  .. 
+PF06393 BH3 interacting domain (BID)<br>Pfam-B_16321 (release 9.0). BID is a member of the BCL-2 superfamily of proteins are  key regulators of programmed cell death, hence this family is related to Pfam:PF00452 .  BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event, exposing  the BH3 domain and significantly changing the surface  charge and hydrophobicity, which causes a change of  cellular localisation  .. 
+PF06394 Pepsin inhibitor-3-like repeated domain<br>Pfam-B_13438 (release 9.0). Pepsin inhibitor-3 consisting of two domains, each comprising an antiparallel beta-sheet flanked by  an alpha-helix. In the enzyme-inhibitor complex, the  N-terminal beta-strand of PI-3 pairs with one strand  of the active site flap region of pepsin  . The two domains are tandem repeats of sequence, and has therefore been termed repeated domain.. 
+PF06395 CDC24 Calponin<br>Pfam-B_32837 (release 8.0). Is a calponin homology domain.. 
+PF06396 Angiotensin II, type I receptor-associated protein (AGTRAP)<br>Pfam-B_15509 (release 9.0). This family consists of several angiotensin II, type I receptor-associated protein (AGTRAP) sequences. AGTRAP is known to interact specifically with the carboxyl-terminal cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to regulate different aspects of AT(1) receptor physiology [1,2]. The function of this family is unclear.. 
+PF06397 Desulfoferrodoxin, N-terminal domain<br>Pfam-B_11142 (release 9.0). Most members of this family are small (approximately 36 amino acids) proteins that from homodimeric complexes. Each subunit contains a high-spin iron atom tetrahedrally bound to four cysteinyl sulphur atoms This family has a similar fold to the rubredoxin metal binding domain  . It is also found as the N-terminal domain of desulfoferrodoxin, see (Pfam:PF01880).. 
+PF06398 Integral peroxisomal membrane peroxin<br>Pfam-B_56111 (release 8.0). Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolism and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p  .. 
+PF06399 GTP cyclohydrolase I feedback regulatory protein (GFRP)<br>Pfam-B_63435 (release 9.0). Tetrahydrobiopterin, the cofactor required for hydroxylation  of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism  is mediated by the regulatory subunit called GTP cyclohydrolase  I feedback regulatory protein (GFRP)  .. 
+PF06400 Alpha-2-macroglobulin RAP, N-terminal domain<br>Pfam-B_44514 (release 9.0). The alpha-2-macroglobulin receptor-associated protein (RAP)  is a intracellular glycoprotein that binds to the 2-macroglobulin  receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of  all currently known ligands of these receptors  .  The N-terminal domain is predominately alpha helical  . Two different studies have provided conflicted domain boundaries [2,3].. 
+PF06401 Alpha-2-macroglobulin RAP, C-terminal domain <br>Pfam-B_44514 (release 9.0). The alpha-2-macroglobulin receptor-associated protein (RAP)  is a intracellular glycoprotein that binds to the 2-macroglobulin  receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of  all currently known ligands of these receptors  .   Two different studies have provided conflicted domain boundaries [2,3].. 
+PF06403 Lamprin<br>Pfam-B_15493 (release 9.0). This family consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage. Although not generally homologous to any other protein, soluble lamprins contain a tandemly repeated peptide sequence (GGLGY) which is present in both silkmoth chorion proteins and spider dragline silk. Strong homologies to this repeat sequence are also present in several mammalian and avian elastins. It is thought that these proteins share a structural motif which promotes self-aggregation and fibril formation in proteins through interdigitation of hydrophobic side chains in beta-sheet/beta-turn structures, a motif that has been preserved in recognisable form over several hundred million years of evolution  .. 
+PF06404 Phytosulfokine precursor protein (PSK)<br>Pfam-B_16071 (release 9.0). This family consists of several plant specific phytosulfokine precursor proteins. Phytosulfokines, are active as either a pentapeptide or a C-terminally truncated tetrapeptide. These compounds were first isolated because of their ability to stimulate cell division in somatic embryo cultures of Asparagus officinalis  .. 
+PF06405 Red chlorophyll catabolite reductase (RCC reductase)<br>Pfam-B_15577 (release 9.0). This family consists of several red chlorophyll catabolite reductase (RCC reductase) proteins. Red chlorophyll catabolite (RCC) reductase (RCCR) and pheophorbide (Pheide) a oxygenase (PaO) catalyse the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of Pheide a to a primary fluorescent catabolite (pFCC)  . . 
+PF06406 StbA protein<br>Pfam-B_12747 (release 9.0). This family consists of several bacterial StbA plasmid stability proteins  .. 
+PF06407 Borna disease virus P40 protein<br>Pfam-B_15995 (release 9.0). This family consists of several Borna disease virus P40 proteins. Borna disease (BD) is a persistent viral infection of the central nervous system caused by the single-negative-strand, nonsegmented RNA Borna disease virus (BDV). P40 is known to be a nucleoprotein  .. 
+PF06409 Nuclear pore complex interacting protein (NPIP)<br>Pfam-B_16418 (release 9.0). This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans  .. 
+PF06411 HdeA/HdeB family<br>Pfam-B_63431 (release 9.0). HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localised in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS [1,2]. This family also contains HdeB  .. 
+PF06412 Conjugal transfer protein TraD<br>Pfam-B_11863 (release 9.0). This family contains bacterial TraD conjugal transfer proteins  .  Mutations in the TraD gene result in loss of transfer  .. 
+PF06413 Neugrin<br>Pfam-B_11274 (release 9.0). This family consists of several mouse and human neugrin proteins. Neugrin and m-neugrin are mainly expressed in neurons in the nervous system, and are thought to play an important role in the process of neuronal differentiation  .. 
+PF06414 Zeta toxin<br>Pfam-B_12374 (release 9.0). This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid  .. 
+PF06415 BPG-independent PGAM N-terminus (iPGM_N)<br>Pfam-B_1338 (release 10.0). This family represents the N-terminal region of the 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (or phosphoglyceromutase or BPG-independent PGAM) protein (EC:5.4.2.1). The family is found in conjunction with Pfam:PF01676 (located in the C-terminal region of the protein).. 
+PF06416 Protein of unknown function (DUF1076)<br>Pfam-B_2653 (release 9.0). This family consists of several hypothetical bacterial proteins exclusive to Escherichia coli and Salmonella typhi. The function of this family is unknown.. 
+PF06417 Protein of unknown function (DUF1077)<br>Pfam-B_6645 (release 9.0). This family consists of several hypothetical eukaryotic proteins of unknown function.. 
+PF06418 CTP synthase N-terminus<br>Pfam-B_226 (release 10.0). This family consists of the N-terminal region of the CTP synthase protein (EC:6.3.4.2). This family is found in conjunction with Pfam:PF00117 located in the C-terminal region of the protein. CTP synthase catalyses the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position  .. 
+PF06419 Conserved oligomeric complex COG6<br>Pfam-B_10345 (release 8.0). COG6 is a component of the conserved oligomeric golgi complex,  which is composed of eight different subunits and is required  for normal golgi morphology and localisation.. 
+PF06420 Mitochondrial genome maintenance MGM101<br>Pfam-B_35151 (release 8.0). The mgm101 gene was identified as essential for maintenance of the mitochondrial genome in Saccharomyces cerevisiae  . Based on its DNA-binding activity, and experimental work with a temperature-sensitive mgm101 mutant, it has been proposed that the mgm101 gene product performs an essential function in the repair of oxidatively damaged mitochondrial DNA  .. 
+PF06421 GTP-binding protein LepA C-terminus<br>Pfam-B_425 (release 10.0). This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins  .. 
+PF06422 CDR ABC transporter<br>Pfam-B_1005 (release 8.0). Corresponds to a region of the PDR/CDR subgroup of ABC transporters comprising extracellular loop 3, transmembrane segment 6 and linker region.. 
+PF06423 GWT1<br>Pfam-B_15982 (release 8.0). Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast [1-2].. 
+PF06424 PRP1 splicing factor, N-terminal<br>Pfam-B_6467 (release 8.0). This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1  . It is involved in    mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.. 
+PF06426 Serine acetyltransferase, N-terminal <br>Pfam-B_1192 (release 8.0). The N-terminal domain of serine acetyltransferase has a sequence that is conserved in plants   and bacteria  .. 
+PF06427 UDP-glucose:Glycoprotein Glucosyltransferase<br>Pfam-B_4648 (release 8.0). The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase.. 
+PF06428 GDP/GTP exchange factor Sec2p<br>Pfam-B_10665 (release 8.0). In Saccharomyces cerevisiae,  Sec2p is a GDP/GTP exchange factor for Sec4p, which is required for vesicular transport at the post-Golgi stage of yeast secretion  .. 
+PF06429 DUF1078;<br>Flagellar basal body rod FlgEFG protein C-terminal. Pfam-B_807 (release 10.0). This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which Pfam:PF00460 is often present at the extreme N terminus.. 
+PF06430 Lactococcus lactis RepB C-terminus<br>Pfam-B_717 (release 10.0). This family consists of the C-terminal region of RepB proteins from Lactococcus lactis (See Pfam:PF01051).. 
+PF06431 Polyomavirus large T antigen C-terminus<br>Pfam-B_214 (release 10.0). 
+PF06432 Phosphatidylinositol N-acetylglucosaminyltransferase<br>Pfam-B_33496 (release 8.0). Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This  step involves products of three or four genes in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.. 
+PF06433 Me-amine-deh_H;<br>Methylamine dehydrogenase heavy chain (MADH). Pfam-B_20644 (release 9.0). Methylamine dehydrogenase (EC:1.4.99.3) a periplasmic quinoprotein found in several methyltrophic bacteria. Induced when grown on methylamine as a carbon source MADH catalyses the oxidative deamination of amines to there corresponding aldehydes.  MADH is a hetero- tetramer, comprised of two heavy chains (H) and two light chains (L).  The H-chain forms a beta-propeller like structure  .. 
+PF06434 Aconitate hydratase 2 N-terminus<br>Pfam-B_2605 (release 10.0). This family represents the N-terminal region of several bacterial Aconitate hydratase 2 proteins and is found in conjunction with Pfam:PF00330.. 
+PF06435 Repeat of unknown function (DUF1079)<br>Pfam-B_1911 (release 10.0). This family consists of several repeats of 31 residues in length and seems to be exclusive to Moraxella catarrhalis UspA proteins. The UspA1 and UspA2 proteins of Moraxella catarrhalis are structurally related and are exposed on the bacterial cell surface where can function adhesins  . This family is commonly found with the Pfam:PF03895 family.. 
+PF06436 Pneumovirus matrix protein 2 (M2)<br>Pfam-B_2318 (release 10.0). This family consists of several Pneumovirus matrix glycoprotein M2 sequences. This family functions as a transcription processivity factor that is essential for virus replication  .. 
+PF06437 IMP-specific 5'-nucleotidase<br>Pfam-B_43910 (release 8.0). The Saccharomyces cerevisiae ISN1 (YOR155c) gene encodes an IMP-specific 5'-nucleotidase, which catalyses degradation of IMP to inosine as part of the purine salvage pathway.. 
+PF06438 Heme-binding protein A (HasA)<br>Pfam-B_27216 (release 9.0). Free iron is limited in vertebrate hosts, thus an alternative to siderophores has been developed by pathogenic bacteria to access host iron bound in protein complexes.  HasA is a secreted hemophore that has the ability to obtain iron from hemoglobin. Once bound to HasA, the heme is shuttled to the receptor HasR, which releases the heme into the bacterium  .. 
+PF06439 Domain of Unknown Function (DUF1080)<br>Yeats C, Eberhardt R. This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.. 
+PF06440 DNA polymerase III, theta subunit<br>Pfam-B_27631 (release 9.0). DNA polymerase III (EC 2.7.7.7) is comprised of three tightly associated subunits, alpha, epsilon and theta. This family contains the theta subunit.   The structure of the theta subunit shows that the N-terminal two thirds is comprised of three helices while the C-terminal third is disordered  .   The function of the theta subunit is poorly understood, but the interaction of the theta subunit with the epsilon subunit is thought to enhance the 3' to 5'  exonucleolytic proofreading activity of epsilon  .. 
+PF06441 Epoxide hydrolase N terminus<br>This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds  . This family is often found in conjunction with Pfam:PF00561.. 
+PF06442 DHFR;<br>R67 dihydrofolate reductase. Pfam-B_27527 (release 9.0). R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial  drug trimethoprim.  The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase  .. 
+PF06443 SEF14-like adhesin <br>Pfam-B_36358 (release 9.0). Family of enterotoxigenic bacterial adhesins. . 
+PF06444 NADH dehydrogenase subunit 2 C-terminus<br>Pfam-B_1662 (release 10.0). This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with Pfam:PF00361.. 
+PF06445 AraC_E_bind;<br>GyrI-like small molecule binding domain. Pfam-B_36124 (release 9.0). This family contains the small molecule binding domain of a number of different bacterial transcription activators  .\. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding  .  The GyrI superfamily includes a family of secreted forms that is  found only in animals and the bacterial pathogen Leptospira  . . 
+PF06446 Hepcidin<br>Pfam-B_41732 (release 9.0). Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin  .. 
+PF06448 Domain of Unknown Function (DUF1081)<br>This region is found in Apolipophorin proteins.. 
+PF06449 Mitochondrial domain of unknown function (DUF1082)<br>Pfam-B_2173 (release 10.0). This family consists of the C-terminal region of several plant mitochondria specific proteins. The function of this family is unknown. This family is found in conjunction with Pfam:PF02326.. 
+PF06450 Bacterial Na+/H+ antiporter B (NhaB)<br>Pfam-B_5993 (release 10.0). This family consists of several bacterial Na+/H+ antiporter B (NhaB) proteins. The exact function of this family is unknown [1,2].. 
+PF06451 Moricin<br>Pfam-B_56760 (release 9.0). Moricin is a antibacterial peptide that is highly basic. The structure of moricin reveals that it is comprised of a long alpha-helix.  The N-terminus of the helix is amphipathic, and the C-terminus of the helix is predominately hydrophobic.  The amphipathic N-terminal segment of the alpha- helix is mainly responsible for the increase in permeability  of the bacterial membrane which kills the bacteria  .. 
+PF06452 Domain of unknown function (DUF1083)<br>Pfam-B_2203 (release 10.0). This family consists of several domains of unknown function exclusively found in bacterial xylanase proteins (usually at the C-terminus) although it is tandemly repeated in a number of family members such as Swiss:P38535. This family is always found in conjunction with Pfam:PF00331 and usually with either Pfam:PF02018 or Pfam:PF00395. The function of this family is unknown.. 
+PF06453 Type II heat-labile enterotoxin , B subunit (LT-IIB)<br>Pfam-B_61882 (release 9.0). Family of B subunits from the type II heat-labile enterotoxin. The B subunits form a pentameric ring, which interacts with one A subunit.  Thus, the structural arrangement of type I and type II heat-labile enterotoxins are very similar  . . 
+PF06454 Protein of unknown function (DUF1084)<br>Pfam-B_12888 (release 10.0). This family consists of several hypothetical plant specific proteins of unknown function.. 
+PF06455 NADH dehydrogenase subunit 5 C-terminus<br>Pfam-B_3060 (release 10.0). This family represents the C-terminal region of several NADH dehydrogenase subunit 5 proteins and is found in conjunction with Pfam:PF00361 and Pfam:PF00662.. 
+PF06456 Arfaptin-like domain<br>Pfam-B_5314 (release 7.5). Arfaptin interacts with ARF1, a small GTPase involved  in vesicle budding at the Golgi complex and immature secretory granules.  The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix  coiled-coils  . The N-terminal region of ICA69 is similar to arfaptin  . . 
+PF06457 Ectatomin<br>Pfam-B_63420 (release 9.0). Ectatomin is a toxic component from the Ectatomma tuberculatum  ant venom.  It is comprised of two subunits, A and B, which  are homologous.  The structure of ectatomin  reveals that each subunit is comprised of two helices and a connecting hinge region, the forms a hairpin structure that is stabilised by disulphide bridges.  The two hinges are connected by a disulphide bond  .. 
+PF06458 DUF1085; <br>Pfam-B_4243 (release 10.0) & Galperin M. The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with Pfam:PF00746 and Pfam:PF00560.. 
+PF06459 Ryanodine Receptor TM 4-6<br>This region covers TM regions 4-6 of the ryanodine receptor 1 family.. 
+PF06460 Coronavirus NSP13<br>This family covers the NSP13 region of the coronavirus polyprotein. This protein has the predicted function of an mRNA cap-1 methyltransferase function ( ).. 
+PF06461 Domain of Unknown Function (DUF1086)<br>This family consists of several eukaryotic domains of unknown function which are present in chromodomain helicase DNA binding proteins. This domain is often found in conjunction with Pfam:PF00176, Pfam:PF00271, Pfam:PF06465, Pfam:PF00385 and Pfam:PF00628.. 
+PF06462 Propeller<br>Probable beta-propeller.. 
+PF06463 Molybdenum Cofactor Synthesis C<br>This region contains two iron-sulphur (3Fe-4S) binding sites. Mutations in this region of  Swiss:O14940 cause MOCOD (Molybdenum Co-Factor Deficiency) type A.. 
+PF06464 DMAP1-binding Domain<br>This domain binds DMAP1, a transcriptional co-repressor.. 
+PF06465 Domain of Unknown Function (DUF1087)<br>Members of this family are found in various chromatin remodelling factors and transposases. Their exact function is, as yet, unknown.. 
+PF06466 PCAF (P300/CBP-associated factor) N-terminal domain<br>This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold -  though predominantly helical.. 
+PF06467 zf_MYM; zf-MYM; <br>MYM-type Zinc finger with FCS sequence motif. MYM-type zinc fingers were identified in MYM family proteins  . Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1  . Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1  ; in atypical myeloproliferative disorders it is rearranged  . Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons  .. 
+PF06468 Spondin_N<br>This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells ( ). . 
+PF06469 Domain of Unknown Function (DUF1088)<br>This family is found in the neurobeachins. The function of this region is not known.. 
+PF06470 SMC proteins Flexible Hinge Domain<br>This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction ( ).  . 
+PF06471 NSP11<br>This region of coronavirus polyproteins encodes the NSP11 protein.. 
+PF06472 Ald_N; <br>ABC transporter transmembrane region 2. This domain covers the transmembrane of a small family of ABC transporters and shares sequence similarity with Pfam:PF00664. Mutations in this domain in Swiss:P28288 are believed responsible for Zellweger Syndrome-2  ; mutations in  Swiss:P33897 are responsible for recessive X-linked adrenoleukodystrophy  . A Saccharomyces cerevisiae homolog is involved in the import of long-chain fatty acids  .. 
+PF06473 FGF binding protein 1 (FGF-BP1)<br>Pfam-B_14221 (release 10.0). This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development  . Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2  .. 
+PF06474 MltD lipid attachment motif<br>This short motif is a lipid attachment site.. 
+PF06475 DUF1089;<br>Putative glycolipid-binding. Pfam-B_14397 (release 10.0). This family has a novel fold known as a spiral beta-roll, consisting of a 15-stranded beta sheet wrapped around a single alpha helix. It forms dimers. It has some structural similarity to the E. coli lipoprotein localisation factors LolA, Swiss:P61316 and LolB, Swiss:P61320. Its structure suggests that it may have a role in glycolipid binding. Its genomic context supports a role in glycolipid metabolism  .. 
+PF06476 Protein of unknown function (DUF1090)<br>Pfam-B_14862 (release 10.0). This family consists of several bacterial proteins of unknown function and is known as YqjC in E. coli.. 
+PF06477 Protein of unknown function (DUF1091)<br>Pfam-B_14929 (release 10.0). This is a family of uncharacterised proteins. Based on its distant similarity to Pfam:PF02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding.. 
+PF06478 Coronavirus RPol N-terminus<br>This family covers the N-terminal region of the  coronavirus RNA-directed RNA Polymerase.. 
+PF06479 Ribonuclease 2-5A<br>This domain is a endoribonuclease  . Specifically it cleaves  an intron from Hac1 mRNA in humans, which causes it to be much more efficiently translated.. 
+PF06480 FtsH Extracellular<br>This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes ( ). It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In  Oenococcus oeni FtsH is involved in protection against  environmental stress ( ), and shows increased expression  under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.. 
+PF06481 COX Aromatic Rich Motif<br>COX2 (Cytochrome O ubiquinol OXidase 2) is a major component of the respiratory complex during vegetative growth. It  transfers electrons from a quinol to the binuclear centre  of the catalytic subunit 1. The function of this region is not known.. 
+PF06482 Coll_NC10;<br>Collagenase NC10 and Endostatin. NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor ( ). Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to ( ).. 
+PF06483 Chitinase C<br>This ~170 aa region is found at the C-terminus of Pfam:PF00704.. 
+PF06484 Teneurin Intracellular Region<br>This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional  regulatory activity ( ). The length of this region and  the conservation suggests that there may be two structural domains here (personal obs:C Yeats).. 
+PF06485 Protein of unknown function (DUF1092)<br>Pfam-B_14522 (release 10.0). This family consists of several hypothetical proteins of unknown function all from photosynthetic organisms including plants and cyanobacteria.. 
+PF06486 Protein of unknown function (DUF1093)<br>Pfam-B_15034 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06487 Sin3 associated polypeptide p18 (SAP18)<br>Pfam-B_15078 (release 10.0). This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides  . SAP18 is also present in the ASAP complex  which is thought to be involved in the regulation of splicing during the execution of programmed cell death  .. 
+PF06488 Lactococcus lactis bacteriophage major structural protein<br>Pfam-B_13945 (release 10.0). This family consists of several Lactococcus lactis bacteriophage major structural proteins.. 
+PF06489 Orthopoxvirus A49R protein<br>Pfam-B_14072 (release 10.0). This family consists of several Orthopoxvirus A49R proteins. The function of this family is unknown.. 
+PF06490 Flagellar regulatory protein FleQ<br>Pfam-B_13480 (release 9.0). This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators that are involved in regulation of flagellar motility e.g. FleQ in Pseudomonas aeruginosa.  It is clearly related to Pfam:PF00072, but lacks the conserved aspartate residue that undergoes phosphorylation in the classic two-component system response regulator (Pfam:PF00072).. 
+PF06491 DUF1094;<br>Disulphide isomerase. Pfam-B_14101 (release 10.0). This family of proteins has disulphide isomerase activity, EC:5.3.4.1. It has a similar fold to thioredoxin, with an alpha-beta-alpha-beta-alpha-beta-beta-alpha topology. It has a conserved CGC motif in the loop immediately downstream of the first beta strand. This motif is essential for activity  .. 
+PF06493 Protein of unknown function (DUF1096)<br>Pfam-B_15011 (release 10.0). This family represents the N-terminal region of several proteins found in C. elegans. The family is often found with Pfam:PF02363.. 
+PF06495 Fruit fly transformer protein<br>Pfam-B_13780 (release 10.0). This family consists of transformer proteins from several Drosophila species and also from Ceratitis capitata (Mediterranean fruit fly). The transformer locus (tra) produces an RNA processing protein that alternatively splices the doublesex pre-mRNA in the sex determination hierarchy of Drosophila melanogaster  .. 
+PF06496 Protein of unknown function (DUF1097)<br>Pfam-B_15055 (release 10.0). This family consists of several bacterial putative membrane proteins.. 
+PF06497 Protein of unknown function (DUF1098)<br>Pfam-B_15446 (release 10.0). This family consists of several hypothetical Baculovirus proteins of unknown function.. 
+PF06500 Alpha/beta hydrolase of unknown function (DUF1100)<br>Pfam-B_15719 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.. 
+PF06501 Human herpesvirus U55 protein<br>Pfam-B_15779 (release 10.0). This family consists of several human herpesvirus U55 proteins. The function of this family is unknown.. 
+PF06502 Equine infectious anaemia virus S2 protein<br>Pfam-B_15780 (release 10.0). This family consists of several equine infectious anaemia virus S2 proteins. The function of this family is unknown.. 
+PF06503 Protein of unknown function (DUF1101)<br>Pfam-B_15836 (release 10.0). This family consists of several hypothetical Fijivirus proteins of unknown function.. 
+PF06504 Replication protein C (RepC)<br>Pfam-B_15903 (release 10.0). This family consists of several bacterial replication protein C (RepC) sequences.. 
+PF06505 Activator of aromatic catabolism<br>Pfam-B_2890 (release 9.0). This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators in several proteobacteria, including activators of phenol degradation such as XylR. It is found adjacent to Pfam:PF02830.. 
+PF06506 Propionate catabolism activator<br>Pfam-B_10794 (release 9.0). This domain is found at the N terminus of several sigma54- dependent transcriptional activators including PrpR, which activates catabolism of propionate.. 
+PF06507 Auxin response factor<br>Pfam-B_2015 (release 9.0). A conserved region of auxin-responsive transcription factors.. 
+PF06508 ExsB;<br>Queuosine biosynthesis protein QueC. Pfam-B_715 (release 9.0). This family of proteins participate in the biosynthesis of 7-carboxy-7-deazaguanine. They catalyse the conversion of 7-deaza-7-carboxyguanine to preQ0 [1-3].. 
+PF06510 Protein of unknown function (DUF1102)<br>Pfam-B_16043 (release 10.0). This family consists of several hypothetical archaeal proteins of unknown function.. 
+PF06511 Invasion plasmid antigen IpaD<br>Pfam-B_16150 (release 10.0). This family consists of several invasion plasmid antigen IpaD proteins. Entry of Shigella flexneri into epithelial cells and lysis of the phagosome involve the IpaB, IpaC, and IpaD proteins, which are secreted by type III secretion machinery.. 
+PF06512 Sodium ion transport-associated<br>Pfam-B_16808 (release 10.0). Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of Pfam:PF00520 and, less often, one copy of Pfam:PF00612.. 
+PF06513 Repeat of unknown function (DUF1103)<br>Pfam-B_16075 (release 10.0). This family consists of several repeats of around 30 residues in length which are found specifically in mature-parasite-infected erythrocyte surface antigen proteins from Plasmodium falciparum. This family often found in conjunction with Pfam:PF00226.. 
+PF06514 Photosystem II 12 kDa extrinsic protein (PsbU)<br>Pfam-B_13782 (release 10.0). This family consists of several photosystem II 12 kDa extrinsic protein (PsbU) proteins from cyanobacteria and algae. PsbU is an extrinsic protein of the photosystem II complex of cyanobacteria and red algae. PsbU is known to stabilise the oxygen-evolving machinery of the photosystem II complex against heat-induced inactivation  . This family appears to be related to the Helix-hairpin-helix domain.. 
+PF06515 Borna disease virus P10 protein<br>Pfam-B_16237 (release 10.0). This family consists of several Borna disease virus P10 (or X) proteins. Borna disease virus (BDV) is unique among the non-segmented negative-strand RNA viruses of animals and man because it transcribes and replicates its genome in the nucleus of the infected cell. It has been suggested that the p10 protein plays a role in viral RNA synthesis or ribonucleoprotein transport  .. 
+PF06516 Purine nucleoside permease (NUP)<br>Pfam-B_15961 (release 10.0). This family consists of several purine nucleoside permease from both bacteria and fungi  .. 
+PF06517 Orthopoxvirus A43R protein<br>Pfam-B_16577 (release 10.0). This family consists of several Orthopoxvirus A43R proteins. The function of this family is unknown.. 
+PF06518 Protein of unknown function (DUF1104)<br>Pfam-B_16082 (release 10.0). This family consists of several hypothetical proteins of unknown function which appear to be found largely in Helicobacter pylori.. 
+PF06519 TolA C-terminal<br>Pfam-B_16081 (release 10.0). This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function.  Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See Pfam:PF01024).  TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm  .. 
+PF06521 PAR1 protein<br>Pfam-B_16232 (release 10.0). This family consists of several plant specific PAR1 proteins from Nicotiana tabacum and Arabidopsis thaliana. The function of this family is unknown.. 
+PF06522 NADH-ubiquinone reductase complex 1 MLRQ subunit<br>Pfam-B_16238 (release 10.0). The MLRQ subunit of mitochondrial NADH-ubiquinone reductase complex I is nuclear   and is found in plants  , insects, fungi and higher metazoans  . It appears to act within the membrane and, in mammals, is highly expressed in muscle and neural tissue, indicative of a role in ATP generation  .. 
+PF06523 Protein of unknown function (DUF1106)<br>Pfam-B_16281 (release 10.0). This family consists of several hypothetical bacterial proteins found in Escherichia coli and Citrobacter rodentium. The function of this family is unknown.. 
+PF06524 NOA36 protein<br>Pfam-B_16330 (release 10.0). This family consists of several NOA36 proteins which contain 29 highly conserved cysteine residues. The function of this protein is unknown.. 
+PF06525 Sulfocyanin (SoxE)<br>Pfam-B_16349 (release 10.0). This family consists of several archaeal sulfocyanin (or blue copper protein) sequences from a number of Sulfolobus species.. 
+PF06526 Protein of unknown function (DUF1107)<br>Pfam-B_16434 (release 10.0). This family consists of several short, hypothetical bacterial proteins of unknown function.. 
+PF06527 TniQ<br>Pfam-B_16755 (release 10.0). This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons  .. 
+PF06528 Phage P2 GpE<br>Pfam-B_15359 (release 10.0). This family consists of several phage and bacterial proteins which are closely related to the GpE tail protein from Phage P2.. 
+PF06529 Vertebrate interleukin-3 regulated transcription factor<br>Pfam-B_16154 (release 10.0). This family includes vertebrate transcription factors, some of which are regulated by IL-3/adenovirus E4 promoter binding protein  . Others were found to strongly repress transcription in a DNA-binding-site-dependent manner  .. 
+PF06530 Phage antitermination protein Q<br>Pfam-B_3979 (release 10.0). This family consists of several phage antitermination protein Q and related bacterial sequences. Antiterminator proteins control gene expression by recognising control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream  .  . 
+PF06531 Protein of unknown function (DUF1108)<br>Pfam-B_16830 (release 10.0). This family consists of several bacterial proteins from Staphylococcus aureus as well as a number of phage proteins. The function of this family is unknown.. 
+PF06532 Protein of unknown function (DUF1109)<br>Pfam-B_17952 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06533 Protein of unknown function (DUF1110)<br>Pfam-B_18243 (release 10.0). This family consists of hypothetical proteins specific to Oryza sativa. One sequence (Swiss:Q943P1) appears to be tandemly repeated.. 
+PF06534 Repulsive guidance molecule (RGM) C-terminus<br>Pfam-B_18263 (release 10.0). This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum  .. 
+PF06535 Repulsive guidance molecule (RGM) N-terminus<br>Pfam-B_18263 (release 10.0). This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum  .. 
+PF06536 Avian adenovirus fibre<br>Pfam-B_16053 (release 10.0). This family contains avian adenovirus fibre proteins, which have been linked to variations in virulence  . Avian adenoviruses possess penton capsomers that consist of a pentameric base associated with two fibres  .. 
+PF06537 Protein of unknown function (DUF1111)<br>Pfam-B_16636 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06540 Galanin message associated peptide (GMAP)<br>Pfam-B_16759 (release 10.0). This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown  .. 
+PF06541 Protein of unknown function (DUF1113)<br>Pfam-B_17933 (release 10.0). This family consists of several bacterial proteins of unknown function.. 
+PF06542 DUF1114; <br>Regulator protein PHA-1. Vella Briffa B, Sammut SJ, Pollington J. Pfam-B_16084 (release 10.0). This family represents the protein product of the gene pha-1 which coordinates with lin-35 Rb during animal development. The protein is expressed during embryonic development and functions in the cytoplasm. PHA-1 acts in a parallel pathway with UBC-18 to regulate the activity of a common cellular target  .. 
+PF06543 Lactococcus bacteriophage repressor<br>Pfam-B_16088 (release 10.0). This family represents the C-terminus of Lactococcus bacteriophage repressor proteins.. 
+PF06544 Protein of unknown function (DUF1115)<br>Vella Briffa B, Sammut SJ. Pfam-B_16104 (release 10.0). This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.. 
+PF06545 Protein of unknown function (DUF1116)<br>Pfam-B_16143 (release 10.0). This family contains hypothetical bacterial proteins of unknown function.. 
+PF06546 Vertebrate heat shock transcription factor<br>Pfam-B_16244 (release 10.0). This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress  . This C-terminal region is found with the N-terminal Pfam:PF00447, and may contain a three-stranded coiled-coil trimerisation domain and a CE2 regulatory region, the latter of which is  involved in sustained heat shock response  .. 
+PF06547 Protein of unknown function (DUF1117)<br>Pfam-B_16251 (release 10.0). This family represents the C-terminus of a number of hypothetical plant proteins.. 
+PF06548 Kinesin-related<br>Pfam-B_16517 (release 10.0). This family represents a region within kinesin-related proteins from higher plants. Many family members also contain the Pfam:PF00225 domain. Kinesins are ATP-driven microtubule motor proteins that produce directed force  . Some family members are associated with the phragmoplast, a structure composed mainly of microtubules that executes cytokinesis in higher plants  .. 
+PF06549 Protein of unknown function (DUF1118)<br>Pfam-B_17963 (release 10.0). This family consists of several hypothetical plant proteins of unknown function.. 
+PF06550 Protein of unknown function (DUF1119)<br>Pfam-B_17985 (release 10.0). This family consists of several hypothetical archaeal proteins of unknown function.. 
+PF06551 Protein of unknown function (DUF1120)<br>Pfam-B_17948 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06552 Plant specific mitochondrial import receptor subunit TOM20<br>Pfam-B_17991 (release 10.0). This family consists of several plant specific mitochondrial import receptor subunit TOM20 (translocase of outer membrane 20 kDa subunit) proteins. Most mitochondrial proteins are encoded by the nuclear genome, and are synthesised in the cytosol. TOM20 is a general import receptor that binds to mitochondrial pre-sequences in the early step of protein import into the mitochondria  .  . 
+PF06553 BNIP3<br>Pfam-B_18014 (release 10.0). This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation  .. 
+PF06554 Olfactory marker protein<br>Pfam-B_18049 (release 10.0). This family consists of several olfactory marker proteins. Expression of the olfactory marker protein (OMP) is highly restricted to mature olfactory receptor neurons in virtually all vertebrate species from fish to man.. 
+PF06556 IAP-like protein p27 C-terminus<br>Pfam-B_18169 (release 10.0). This family represents the C-terminal region of the African swine fever virus IAP-like protein p27. This family is found in conjunction with Pfam:PF00653. It has been suggested that the family may be a host range gene involved in aspects of infection in the arthropod host, ticks of the genus Ornithodoros  .. 
+PF06557 Protein of unknown function (DUF1122)<br>Pfam-B_18183 (release 10.0). This family consists of several hypothetical archaeal and bacterial proteins of unknown function.. 
+PF06558 Secretion monitor precursor protein (SecM)<br>Pfam-B_18197 (release 10.0). This family consists of several bacterial Secretion monitor precursor (SecM) proteins. SecM is known to regulate SecA expression. The eubacterial protein secretion machinery consists of a number of soluble and membrane associated components. One critical element is SecA ATPase, which acts as a molecular motor to promote protein secretion at translocation sites that consist of SecYE, the SecA receptor, and SecG and SecDFyajC proteins, which regulate SecA membrane cycling  .. 
+PF06559 2'-deoxycytidine 5'-triphosphate deaminase (DCD)<br>Pfam-B_18211 (release 10.0). This family consists of several bacterial 2'-deoxycytidine 5'-triphosphate deaminase proteins (EC:3.5.4.13).. 
+PF06560 Glucose-6-phosphate isomerase (GPI)<br>Pfam-B_18250 (release 10.0). This family consists of several bacterial and archaeal glucose-6-phosphate isomerase (GPI) proteins (EC:5.3.1.9).. 
+PF06563 Protein of unknown function (DUF1125)<br>Pfam-B_18065 (release 10.0). This family consists of several short Lactococcus lactis and bacteriophage proteins. The function of this family is unknown.. 
+PF06564 YhjQ protein<br>Pfam-B_18260 (release 10.0). This family consists of several bacterial YhjQ proteins. The function of this family is unknown. However, the family does contain a P-loop sequence motif suggesting a nucleotide binding function.. 
+PF06565 Repeat of unknown function (DUF1126)<br>Pfam-B_18695 (release 10.0). This family consists of several eukaryote specific repeats of around 35 residues in length. The function of this family is unknown.. 
+PF06566 Chondroitin sulphate attachment domain<br>Pfam-B_16515 (release 10.0). This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis  . This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation  .. 
+PF06567 Neural chondroitin sulphate proteoglycan cytoplasmic domain<br>Pfam-B_16515 (release 10.0). This family represents the C-terminal cytoplasmic domain of vertebrate neural chondroitin sulphate proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis  . This domain contains a number of potential sites of phosphorylation by protein kinase C  .. 
+PF06568 Domain of unknown function (DUF1127)<br>Pfam-B_18606 (release 10.0). This family is found in several hypothetical bacterial proteins. In some cases it represents it represents the C-terminal region whereas in others it represents the whole sequence.. 
+PF06569 Protein of unknown function (DUF1128)<br>Pfam-B_18651 (release 10.0). This family consists of several short, hypothetical bacterial proteins of unknown function.. 
+PF06570 Protein of unknown function (DUF1129)<br>Pfam-B_18737 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06572 Protein of unknown function (DUF1131)<br>Pfam-B_18811 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06573 Churchill protein<br>Pfam-B_19061 (release 10.0). This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signaling during neural development (unpublished obs Sheng G and Stern C).. 
+PF06574 Flavokinase; <br>Moxon SJ, Mistry J, Eddy S. Pfam-B_18632 (release 10.0). This family corresponds to the N terminal domain of the bifunctional enzyme riboflavin kinase / FAD synthetase. These enzymes have both ATP:riboflavin 5'-phospho transferase and ATP:FMN-adenylyltransferase activity  .  They catalyse the 5'-phosphorylation of riboflavin to FMN and the adenylylation of FMN to FAD  .  This domain is thought to have the flavin mononucleotide (FMN) adenylyltransferase activity  .. 
+PF06575 Protein of unknown function (DUF1132)<br>Pfam-B_19091 (release 10.0). This family consists of several hypothetical proteins from Neisseria meningitidis. The function of this family is unknown.. 
+PF06576 Protein of unknown function (DUF1133)<br>Pfam-B_19184 (release 10.0). This family consists of a number of hypothetical proteins from Escherichia coli O157:H7 and Salmonella typhi. The function of this family is unknown.. 
+PF06577 Protein of unknown function (DUF1134)<br>Pfam-B_19217 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06578 YOP proteins translocation protein K (YscK)<br>Pfam-B_19248 (release 10.0). This family consists of several YscK proteins. The function of this protein is unknown but it belongs to an operon involved in the secretion of Yop proteins across bacterial membranes.. 
+PF06579 Caenorhabditis elegans ly-6-related protein<br>Pfam-B_19267 (release 10.0). This family consists of several Caenorhabditis elegans specific ly-6-related HOT and ODR proteins. These proteins are involved in the olfactory system. Odr-2 mutants are known to be defective in the ability to chemotax to odorants that are recognised by the two AWC olfactory neurons. Odr-2 encodes a membrane-associated protein related to the Ly-6 superfamily of GPI-linked signaling proteins  .. 
+PF06580 Histidine kinase<br>Pfam-B_794 (release 10.0). This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence  . Members of this family often contain Pfam:PF02518 and/or Pfam:PF00672.. 
+PF06581 DUF1135;<br>Mad1 and Cdc20-bound-Mad2 binding. Pfam-B_19462 (release 10.0). This family is involved in the cell-cycle surveillance mechanism called the spindle checkpoint. This mechanism monitors the proper bipolar attachment of sister chromatids to spindle microtubules and ensures the fidelity of chromosome segregation during mitosis. A key player in mitosis is Mad2, and Mad2 exhibits an unusual two-state behaviour. A Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerisation and converts Mad2 to a conformer amenable to Cdc20 binding. p31comet inactivates the checkpoint by binding to Mad1- or Cdc20-bound Mad2 in such a way as to stop Mad2 activation and to promote the dissociation of the Mad2-Cdc20 complex  .. 
+PF06582 Repeat of unknown function (DUF1136)<br>Pfam-B_19544 (release 10.0). This family consists of several eukaryote specific repeats of unknown function. This repeat seems to always be found with Pfam:PF00047.. 
+PF06583 Neogenin_C-term; <br>Pfam-B_16188 (release 10.0). This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites  . Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of Pfam:PF00047 and Pfam:PF00041) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues  .. 
+PF06584 DIRP<br>Pfam-B_2017 (release 9.0). DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9  and  aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.. 
+PF06585 Haemolymph juvenile hormone binding protein (JHBP)<br>Pfam-B_19686 (release 10.0). This family consists of several insect-specific haemolymph juvenile hormone binding proteins (JHBP). Juvenile hormone regulates embryogenesis, maintains the status quo of larval development and stimulates reproductive maturation in the adult insect. JH is transported from the sites of its synthesis to target tissues by a haemolymph carrier called juvenile hormone-binding protein (JHBP). JHBP protects the JH molecules from hydrolysis by non-specific esterases present in the insect haemolymph  . The crystal structure of the JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organisation of the major cavity and a disulfide bond linking the long helix and the beta-sheet. It would appear that JHBP forms two cavities, only one of which, the one near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance  . This family now includes DUF233, Pfam:PF03027.. 
+PF06586 TraK protein<br>Pfam-B_19687 (release 10.0). This family consists of several TraK proteins from Escherichia coli, Salmonella typhi and Salmonella typhimurium. TraK is known to be essential for pilus assembly but its exact role in this process is unknown  .. 
+PF06587 Protein of unknown function (DUF1137)<br>Pfam-B_20097 (release 10.0). This family consists of several hypothetical proteins specific to Chlamydia species. The function of this family is unknown.. 
+PF06588 Muskelin N-terminus<br>Pfam-B_20299 (release 10.0). This family represents the N-terminal region of muskelin and is found in conjunction with several Pfam:PF01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1  .. 
+PF06589 Circumsporozoite-related antigen (CRA)<br>Pfam-B_19386 (release 10.0). This family consists of several circumsporozoite-related antigen (CRA) or exported protein-1 (EXP1) sequences found specifically in Plasmodium species. The function of this family is unknown.. 
+PF06590 PerB protein<br>Pfam-B_19494 (release 10.0). This family consists of several PerB or BfpV proteins found specifically in Escherichia coli. PerB is thought to play a role in regulating the expression of BfpA  .. 
+PF06591 T4-like phage nuclear disruption protein (Ndd)<br>Pfam-B_19553 (release 10.0). This family consists of several nuclear disruption (Ndd) proteins from T4-like phages. Early in a bacteriophage T4 infection, the phage ndd gene causes the rapid destruction of the structure of the Escherichia coli nucleoid.  The targets of Ndd action may be the chromosomal sequences that determine the structure of the nucleoid  .. 
+PF06592 Protein of unknown function (DUF1138)<br>Pfam-B_19518 (release 10.0). This family consists of several hypothetical short plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.. 
+PF06593 Raspberry bushy dwarf virus coat protein<br>Pfam-B_19630 (release 10.0). This family consists of several Raspberry bushy dwarf virus coat proteins.. 
+PF06594 HCBP_repeat; <br>Haemolysin-type calcium binding protein related domain. Pfam-B_20041 (release 10.0). This family consists of a number of bacteria specific domains which are found in haemolysin-type calcium binding proteins. This family is found in conjunction with Pfam:PF00353 and is often found in multiple copies.. 
+PF06595 Borna disease virus P24 protein<br>Pfam-B_20092 (release 10.0). This family consists of several Borna disease virus (BDV) P24 proteins. The function of this family is unknown.. 
+PF06596 Photosystem II reaction centre X protein (PsbX)<br>Pfam-B_20149 (release 10.0). This family consists of several photosystem II reaction centre X protein (PsbX) sequences from both prokaryotes and eukaryotes.. 
+PF06597 Clostridium P-47 protein<br>Pfam-B_20156 (release 10.0). This family consists of several P-47 proteins from various Clostridium species as well as two related sequences from Pseudomonas putida. The function of this family is unknown.. 
+PF06598 Chlorovirus glycoprotein repeat<br>Pfam-B_19883 (release 10.0). This family consists of s number of repeats found in Chlorovirus glycoproteins. The function of this family is unknown.. 
+PF06599 Protein of unknown function (DUF1139)<br>Pfam-B_20355 (release 10.0). This family consists of several hypothetical Fijivirus proteins of unknown function.. 
+PF06600 Protein of unknown function (DUF1140)<br>Pfam-B_20379 (release 10.0). This family consists of several short, hypothetical phage and bacterial proteins. The function of this family is unknown.. 
+PF06601 Orthopoxvirus F6 protein<br>Pfam-B_20433 (release 10.0). This family consists of several Orthopoxvirus F6L proteins the function of which are unknown.. 
+PF06602 Myotubularin-like phosphatase domain<br>Pfam-B_795 (release 10.0). This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate  . Mutations in gene encoding myotubularin-related proteins have been associated with disease  .. 
+PF06603 DUF1141;<br>UpxZ family of transcription anti-terminator antagonists. Pfam-B_19606 (release 10.0). The UpxZ family of proteins acts to inhibit transcription of heterologous capsular polysaccharide loci in Bacteroides species by interfering with the action of the UpxY family of transcription anti-terminators. As antagonists of polysaccharide locus-specific UpxY transcription anti-terminators, the UpxZ proteins exert a hierarchical level of regulation, insuring that only one of the multiple phase-variable capsular polysaccharide loci per cell characteristic of this genus is transcribed at a time.. 
+PF06605 DUF1142;<br>Prophage endopeptidase tail. Pfam-B_16284 (release 10.0). This family is of prophage tail proteins that are probably acting as endopeptidases.. 
+PF06607 Prokineticin<br>Pfam-B_19802 (release 10.0). This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock  .. 
+PF06608 Protein of unknown function (DUF1143)<br>Pfam-B_19953 (release 10.0). This family consists of several hypothetical mammalian proteins (from mouse and human). The function of this family is unknown.. 
+PF06609 Fungal trichothecene efflux pump (TRI12)<br>Pfam-B_19969 (release 10.0). This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes  .. 
+PF06610 Protein of unknown function (DUF1144)<br>Pfam-B_20026 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06611 Protein of unknown function (DUF1145)<br>Pfam-B_20029 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06612 Protein of unknown function (DUF1146)<br>Pfam-B_20141 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06613 KorB C-terminal beta-barrel domain<br>Pfam-B_20369 (release 10.0). This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon  . This beta-barrel domain is found at the C-terminus of KorB.. 
+PF06614 Neuromodulin<br>Pfam-B_20438 (release 10.0). This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with Pfam:PF00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals  .. 
+PF06615 Protein of unknown function (DUF1147)<br>Pfam-B_20563 (release 10.0). This family consists of several short Circovirus proteins of unknown function.. 
+PF06616 BsuBI/PstI restriction endonuclease C-terminus<br>Pfam-B_16289 (release 10.0). This family represents the C-terminus of bacterial enzymes similar to type II restriction endonucleases BsuBI and PstI (EC:3.1.21.4). The enzymes of the BsuBI restriction/modification (R/M) system recognise the target sequence 5'CTGCAG and are functionally identical with those of the PstI R/M system  .. 
+PF06617 M-phase inducer phosphatase<br>Pfam-B_16267 (release 10.0). This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the Pfam:PF00581 domain. These proteins are involved in the control of mitosis  .. 
+PF06618 Protein of unknown function (DUF1148)<br>Pfam-B_20595 (release 10.0). This family consists of several Maize streak virus proteins of unknown function.. 
+PF06619 Protein of unknown function (DUF1149)<br>Pfam-B_20513 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06620 Protein of unknown function (DUF1150)<br>Pfam-B_20612 (release 10.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF06621 Single-minded protein C-terminus<br>Pfam-B_21144 (release 10.0). This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologues in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerisation partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism  . SIM2 is thought to contribute to some specific Down syndrome phenotypes  . This family is found in conjunction with a Pfam:PF00989 domain and associated Pfam:PF00785 motif.. 
+PF06622 SepQ protein<br>Pfam-B_21060 (release 10.0). This family consists of several enterobacterial SepQ proteins from Escherichia coli and Citrobacter rodentium. The function of this family is unclear.. 
+PF06623 MHC_I C-terminus<br>Pfam-B_21327 (release 10.0). This family represents the C-terminal region of the MHC class I antigen. The family is found in conjunction with Pfam:PF00129 and Pfam:PF00047.. 
+PF06624 Ribosome associated membrane protein RAMP4<br>Pfam-B_20959 (release 10.0). This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER  .. 
+PF06625 Protein of unknown function (DUF1151)<br>Pfam-B_21020 (release 10.0). This family consists of several hypothetical eukaryotic proteins of unknown function.. 
+PF06626 Protein of unknown function (DUF1152)<br>Pfam-B_21029 (release 10.0). This family consists of several hypothetical archaeal proteins of unknown function.. 
+PF06627 Protein of unknown function (DUF1153)<br>Pfam-B_21038 (release 10.0). This family consists of several short, hypothetical bacterial proteins of unknown function.. 
+PF06628 Catalase-related immune-responsive<br>Vella Briffa B, Coggill P. Pfam-B_16304 (release 10.0). This family represents a small conserved region within catalase enzymes (EC:1.11.1.6). All members also contain the Catalase family, Pfam:PF00199 domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects  . This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells  .. 
+PF06629 MltA-interacting protein MipA<br>Pfam-B_8359 (release 9.0). This family consists of several bacterial MltA-interacting protein (MipA) like sequences. As well as interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex  .. 
+PF06630 Enterobacterial exodeoxyribonuclease VIII<br>Pfam-B_11449 (release 9.0). This family consists of several Enterobacterial exodeoxyribonuclease VIII proteins.. 
+PF06631 Protein of unknown function (DUF1154)<br>Pfam-B_16329 (release 10.0). This family represents a small conserved region of unknown function within eukaryotic phospholipase C (EC:3.1.4.3). All members also contain Pfam:PF00387 and Pfam:PF00388.. 
+PF06632 DNA double-strand break repair and V(D)J recombination protein XRCC4<br>Pfam-B_21077 (release 10.0). This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalysed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks  .. 
+PF06633 Protein of unknown function (DUF1155)<br>Pfam-B_21101 (release 10.0). This family consists of several Cucumber mosaic virus ORF IIB proteins. The function of this family is unknown.. 
+PF06634 Protein of unknown function (DUF1156)<br>Vella Briffa B, Eberhardt R. Pfam-B_16387 (release 10.0). This family represents a conserved region within hypothetical prokaryotic and archaeal proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF06635 Nodulation protein NolV<br>Pfam-B_21143 (release 10.0). This family consists of several nodulation protein NolV sequences from different Rhizobium species  . The function of this family is unclear.. 
+PF06636 Protein of unknown function (DUF1157)<br>Pfam-B_21250 (release 10.0). This family consists of several uncharacterised proteins from Melanoplus sanguinipes entomopoxvirus (MsEPV). The function of this family is unknown.. 
+PF06637 PV-1 protein (PLVAP)<br>Pfam-B_21397 (release 10.0). This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms  . The function of this family is unknown.. 
+PF06638 Strabismus protein<br>Pfam-B_9849 (release 9.0). This family consists of several strabismus (STB) or Van Gogh-like (VANGL) proteins 1 and 2. The exact function of this family is unknown. It is thought, however that STB1 gene and STB2 may be potent tumour suppressor gene candidates  .. 
+PF06639 Basal layer antifungal peptide (BAP)<br>Pfam-B_21444 (release 10.0). This family consists of several basal layer antifungal peptide (BAP) sequences specific to Zea mays. The BAP2 peptide exhibits potent broad-range activity against a range of filamentous fungi, including several plant pathogens  . . 
+PF06640 P_prot_C-term; <br>P protein C-terminus. Pfam-B_16385 (release 10.0). This family represents the C-terminus of plant P proteins. The maize P gene is a transcriptional regulator of genes encoding enzymes for flavonoid biosynthesis in the pathway leading to the production of a red phlobaphene pigment  , and P proteins are homologous to the DNA-binding domain of myb-like transcription factors  . All members of this family contain the Pfam:PF00249 domain.. 
+PF06643 Protein of unknown function (DUF1158)<br>Pfam-B_21508 (release 10.0). This family consists of several enterobacterial YbdJ proteins. The function of this family is unknown. 
+PF06644 ATP11 protein<br>Moxon SJ, Hammonds G. Pfam-B_21093 (release 10.0). This family consists of several eukaryotic ATP11 proteins. In Saccharomyces cerevisiae, expression of functional F1-ATPase requires two proteins encoded by the ATP11 and ATP12 genes  . Atp11p is a molecular chaperone of the mitochondrial matrix that participates in the biogenesis pathway to form F1, the catalytic  unit of the ATP synthase  .. 
+PF06645 Microsomal signal peptidase 12 kDa subunit (SPC12)<br>Pfam-B_21331 (release 10.0). This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12).. 
+PF06646 High affinity transport system protein p37<br>Pfam-B_21350 (release 10.0). This family consists of several high affinity transport system protein p37 sequences which are specific to Mycoplasma species. The p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria.It has been suggested that p37 is part of a homologous, high-affinity transport system in M. hyorhinis, a Gram-positive bacterium  .. 
+PF06648 Protein of unknown function (DUF1160)<br>Pfam-B_21501 (release 10.0). This family consists of several hypothetical Baculovirus proteins of unknown function.. 
+PF06649 Protein of unknown function (DUF1161)<br>Pfam-B_21545 (release 10.0). This family consists of several short, hypothetical bacterial proteins of unknown function.. 
+PF06650 Protein of unknown function (DUF1162)<br>Pfam-B_16458 (release 10.0). This family represents a conserved region within several hypothetical eukaryotic proteins. Family members might be vacuolar protein sorting related-proteins. . 
+PF06651 Protein of unknown function (DUF1163)<br>Pfam-B_16509 (release 10.0). This family represents the C-terminus of hypothetical Arabidopsis thaliana proteins of unknown function. . 
+PF06652 Methuselah N-terminus<br>Pfam-B_3337 (release 10.0). This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site  . This family is found in conjunction with Pfam:PF00002.. 
+PF06653 DUF1164;<br>Tight junction protein, Claudin-like. Pfam-B_21553 (release 10.0). This is a family of probable membrane tight junction, Claudin-like, proteins.. 
+PF06656 Tenuivirus PVC2 protein<br>Pfam-B_15006 (release 10.0). This family consists of several Tenuivirus PVC2 proteins from Rice grassy stunt virus, Maize stripe virus and Rice hoja blanca virus. The function of this family is unknown.. 
+PF06657 DUF1167;<br>Centrosome microtubule-binding domain of Cep57. Pfam-B_9878 (release 9.0). This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, Pfam:PF14073, is the centrosome localisation domain Cep57  .. 
+PF06658 Protein of unknown function (DUF1168)<br>Pfam-B_9807 (release 9.0). This family consists of several hypothetical eukaryotic proteins of unknown function. . 
+PF06661 VirE3<br>Pfam-B_16550 (release 10.0). This family represents a conserved region within Agrobacterium tumefaciens VirE3. Agrobacterium tumefaciens (a plant pathogen) has a tumour-inducing (Ti) plasmid of which part, the transfer (T)-region, is transferred to plant cells during the infection process. Vir proteins mediate the processing of the T-region and the transfer of a single-stranded (ss) DNA copy of this region, the T-strand, into the recipient cells. VirE3 is a translocated effector protein, but its specific role has not been established  .. 
+PF06662 C5-epim_C-term; <br>D-glucuronyl C5-epimerase C-terminus. Pfam-B_16571 (release 10.0). This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyse the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans  .. 
+PF06663 Protein of unknown function (DUF1170)<br>Pfam-B_16582 (release 10.0). This family represents a conserved region of unknown function within MAGUIN, a neuronal membrane-associated guanylate kinase-interacting protein. This region is situated between the Pfam:PF00595 and Pfam:PF00169 domains  . All family members also contain an N-terminal Pfam:PF00536 domain.. 
+PF06664 DUF1171; MIG-14_Ce; <br>Wnt-binding factor required for Wnt secretion. Vella Briffa B, Pollington JE. Pfam-B_16593 (release 10.0). MIG-14 is a Wnt-binding factor. Newly synthesised EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion  .. 
+PF06666 Protein of unknown function (DUF1173)<br>Pfam-B_16904 (release 10.0). This family contains a group of hypothetical bacterial proteins that contain three conserved cysteine residues towards the N-terminal. The function of these proteins is unknown.. 
+PF06667 Phage shock protein B<br>Pfam-B_21806 (release 10.0). This family consists of several bacterial phage shock protein B (PspB) sequences. The phage shock protein (psp) operon is induced in response to heat, ethanol, osmotic shock and infection by filamentous bacteriophages  . Expression of the operon requires the alternative sigma factor sigma54 and the transcriptional activator PspF. In addition, PspA plays a negative regulatory role, and the integral-membrane proteins PspB and PspC play a positive one  .. 
+PF06668 ITI_HC_C-term; <br>Inter-alpha-trypsin inhibitor heavy chain C-terminus. Pfam-B_16674 (release 10.0). This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix  . All family members contain the Pfam:PF00092 domain.. 
+PF06669 Xylella fastidiosa surface protein related<br>Pfam-B_21796 (release 10.0). This family consists of several Xylella fastidiosa surface protein specific repeats which are found in found in conjunction with Pfam:PF05662, Pfam:PF05658 and Pfam:PF03895.. 
+PF06670 Microneme protein Etmic-2<br>Pfam-B_22009 (release 10.0). This family consists of several Microneme protein Etmic-2 sequences from Eimeria tenella. Etmic-2 is a 50 kDa acidic protein, which is found within the microneme organelles of Eimeria tenella sporozoites and merozoites  .. 
+PF06671 Repeat of unknown function (DUF1174)<br>Pfam-B_22180 (release 10.0). This family consists of a number of Caenorhabditis elegans specific repeats of around 36 residues in length which are found in two hypothetical proteins. This family is found in conjunction with Pfam:PF00024.. 
+PF06672 Protein of unknown function (DUF1175)<br>Pfam-B_21722 (release 10.0). This family consists of several hypothetical bacterial proteins of around 210 residues in length. The function of this family is unknown.. 
+PF06673 Lactococcus lactis bacteriophage major capsid protein<br>Pfam-B_21754 (release 10.0). This family consists of several Lactococcus lactis bacteriophage major capsid proteins.. 
+PF06674 Protein of unknown function (DUF1176)<br>Pfam-B_21791 (release 10.0). This family consists of several hypothetical bacterial proteins of around 340 residues in length. Members of this family contain six highly conserved cysteine residues. The function of this family is unknown.. 
+PF06675 Protein of unknown function (DUF1177)<br>Pfam-B_21818 (release 10.0). This family consists of several hypothetical archaeal and and bacterial proteins of around 300 residues in length. The function of this family is unknown.. 
+PF06676 Protein of unknown function (DUF1178)<br>Pfam-B_21872 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.. 
+PF06677 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)<br>Pfam-B_21881 (release 10.0). This family consists of several Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) sequences. It is thought that the potential association of anti-p27 with anti-centromere antibodies suggests that autoantigen p27 might play a role in mitosis  .. 
+PF06678 Protein of unknown function (DUF1179)<br>Pfam-B_21899 (release 10.0). This family consists of several hypothetical Caenorhabditis elegans proteins of around 106 residues in length. The function of the family is unknown.. 
+PF06679 Protein of unknown function (DUF1180)<br>Pfam-B_21907 (release 10.0). This family consists of several hypothetical mammalian proteins of around 190 residues in length. The function of this family is unknown.. 
+PF06680 Protein of unknown function (DUF1181)<br>Pfam-B_21912 (release 10.0). This family consists of several hypothetical proteins of around 120 residues in length which are found specifically in Trypanosoma brucei. The function of this family is unknown.. 
+PF06681 Protein of unknown function (DUF1182)<br>Pfam-B_21992 (release 10.0). This family consists of several hypothetical proteins of around 360 residues in length and seems to be specific to Caenorhabditis elegans. The function of this family is unknown.. 
+PF06682 Protein of unknown function (DUF1183)<br>Pfam-B_22014 (release 10.0). This family consists of several eukaryotic proteins of around 360 residues in length. The function of this family is unknown.. 
+PF06683 Protein of unknown function (DUF1184)<br>Pfam-B_16725 (release 10.0). This family contains a number of hypothetical proteins of unknown function from Arabidopsis thaliana.. 
+PF06684 DUF1185;<br>Amino acid synthesis. Moxon SJ, Eberhardt R. Pfam-B_22398 (release 10.0). This family of proteins is structurally similar to proteins with the Bacillus chorismate mutase-like (BCM-like) fold. This structure, combined with its genomic context, suggest that it has a role in amino acid synthesis  .. 
+PF06685 Protein of unknown function (DUF1186)<br>Pfam-B_22662 (release 10.0). This family consists of several hypothetical bacterial proteins of around 250 residues in length and is found in several Chlamydia and Anabaena species. The function of this family is unknown.. 
+PF06686 Stage III sporulation protein AC/AD protein family<br>Pfam-B_22771 (release 10.0), TIGRFAMs. This family consists of several bacterial stage III sporulation protein AC (SpoIIIAC) and SpoIIIAD sequences. The exact function of this family is unknown.  SpoIIIAD is the an uncharacterised protein which is part of the spoIIIA operon that acts at sporulation stage III as part of a cascade of events leading to endospore formation. The operon is regulated by sigmaG  .. 
+PF06687 SUR7/PalI family<br>Pfam-B_22775 (release 10.0). This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homologue of human endophilin, suggesting a function for both in endocytosis [1,2]. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane.  Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localise with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation  . This family also includes PalI which is part of a pH signal transduction cascade.  Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH  .. 
+PF06688 Protein of unknown function (DUF1187)<br>Pfam-B_22781 (release 10.0). This family consists of several short, hypothetical bacterial proteins of around 62 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi. The function of this family is unknown.. 
+PF06689 ClpX C4-type zinc finger<br>Pfam-B_465 (release 10.0). The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of proteins, and possesses a putative zinc finger motif of the C4 type. This presumed zinc binding domain is found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone. The molecular function of this domain is now known.. 
+PF06690 Protein of unknown function (DUF1188)<br>Pfam-B_22902 (release 10.0). This family consists of several hypothetical archaeal proteins of around 260 residues in length which seem to be specific to Methanobacterium, Methanococcus and Methanopyrus species. The function of this family is unknown.. 
+PF06691 Protein of unknown function (DUF1189)<br>Pfam-B_22923 (release 10.0). This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.. 
+PF06692 Melon necrotic spot virus P7B protein<br>Pfam-B_22334 (release 10.0). This family consists of several Melon necrotic spot virus (MNSV) P7B proteins. The function of this family is unknown.. 
+PF06693 Protein of unknown function (DUF1190)<br>Pfam-B_22972 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 212 residues in length and is known as YjfM in Escherichia coli. The function of this family is unknown.. 
+PF06694 Plant nuclear matrix protein 1 (NMP1)<br>Pfam-B_22388 (release 10.0). This family consists of several plant specific nuclear matrix protein 1 (NMP1) sequences. Nuclear Matrix Protein 1 is a ubiquitously expressed 36 kDa protein, which has no homologues in animals and fungi, but is highly conserved among flowering and non-flowering plants. NMP1 is located both in the cytoplasm and nucleus and that the nuclear fraction is associated with the nuclear matrix. NMP1 is a candidate for a plant-specific structural protein with a function both in the nucleus and cytoplasm  . . 
+PF06695 sm_multidrug_ex; <br>Putative small multi-drug export protein. Pfam-B_16747 (release 10.0). This family contains a small number of putative small multi-drug export proteins.. 
+PF06696 Streptococcal surface antigen repeat<br>Pfam-B_22674 (release 10.0). This family consists of a number of ~25 residue long repeats found commonly in Streptococcal surface antigens although one copy is present in the HPSR2-heavy chain potential motor protein of Giardia lamblia (Swiss:Q24984). This family is often found in conjunction with Pfam:PF00746.. 
+PF06697 Protein of unknown function (DUF1191)<br>Pfam-B_16754 (release 10.0). This family contains hypothetical plant proteins of unknown function.. 
+PF06698 Protein of unknown function (DUF1192)<br>Pfam-B_22780 (release 10.0). This family consists of several short, hypothetical, bacterial proteins of around 60 residues in length. The function of this family is unknown.. 
+PF06699 GPI biosynthesis protein family Pig-F<br>Pfam-B_8602 (release 8.0). PIG-F is involved in glycosylphosphatidylinositol (GPI) anchor  biosynthesis [1-3].. 
+PF06701 Mib_herc2<br>Pfam-B_6026 (release 8.0). Named "mib/herc2 domain" in  . Usually the protein also contains an E3 ligase domain (either Ring or Hect). . 
+PF06702 Protein of unknown function (DUF1193)<br>Pfam-B_16766 (release 10.0). This family represents the C-terminus of several hypothetical eukaryotic proteins of unknown function. Family members contain two conserved motifs: DRHHYE and QCC, as well as a number of conserved cysteine residues.. 
+PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25)<br>Pfam-B_22374 (release 10.0). This family consists of several microsomal signal peptidase 25 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 25 kDa subunit (SPC25).. 
+PF06705 SF-assemblin/beta giardin<br>Pfam-B_22934 (release 10.0). This family consists of several eukaryotic SF-assemblin and related beta giardin proteins. During mitosis the SF-assemblin-based cytoskeleton is reorganised; it divides in prophase and is reduced to two dot-like structures at each spindle pole in metaphase. During anaphase, the two dots present at each pole are connected again. In telophase there is an asymmetrical outgrowth of new fibres. It has been suggested that SF-assemblin is involved in re-establishing the microtubular root system characteristic of interphase cells after mitosis  . . 
+PF06706 Citrus tristeza virus 6-kDa protein<br>Pfam-B_22973 (release 10.0). This family consists of several Citrus tristeza virus (CTV) 6-kDa, 51 residue long hydrophobic (P6) proteins. The function of this family is unknown.. 
+PF06707 Protein of unknown function (DUF1194)<br>Pfam-B_22986 (release 10.0). This family consists of several hypothetical Rhizobiales specific proteins of around 270 residues in length. The function of this family is unknown.. 
+PF06708 Protein of unknown function (DUF1195)<br>Pfam-B_22828 (release 10.0). This family consists of several plant specific hypothetical proteins of around 160 residues in length. The function of this family is unknown.. 
+PF06709 Protein of unknown function (DUF1196)<br>Pfam-B_23162 (release 10.0). This family consists of several hypothetical bacterial proteins of around 51 residues in length which seem to be specific to Vibrio cholerae. The function of this family is unknown.. 
+PF06711 Protein of unknown function (DUF1198)<br>Pfam-B_23016 (release 10.0). This family consists of several bacterial proteins of around 150 residues in length which are specific to Escherichia coli, Salmonella species and Yersinia pestis. The function of this family is unknown.. 
+PF06712 Protein of unknown function (DUF1199)<br>Pfam-B_23160 (release 10.0). This family consists of several hypothetical Feline immunodeficiency virus (FIV) proteins. Members of this family are typically around 67 residues long and are often annotated as ORF3 proteins. The function of this family is unknown.. 
+PF06713 DUF1200;<br>Pfam-B_23245 (release 10.0). This family consists of several hypothetical proteins specific to Oceanobacillus and Bacillus species. Members of this family are typically around 130 residues in length. The function of this family is unknown. Members of this family have a PH domain like structure  .. 
+PF06714 Gp5 N-terminal OB domain<br>This domain is found at the N terminus of the Gp5 baseplate protein of bacteriophage T4.  This domain binds to the Gp27 protein  .  This domain has the common OB fold  .. 
+PF06715 Gp5 C-terminal repeat (3 copies)<br>This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5.  This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerise to form a beta solenoid type structure  . This family also includes repeats from bacterial Vgr proteins.. 
+PF06716 Protein of unknown function (DUF1201)<br>Pfam-B_23269 (release 10.0). This family consists of several Sugar beet yellow virus (SBYV) putative membrane-binding proteins of around 54 residues in length. The function of this family is unknown.. 
+PF06717 Protein of unknown function (DUF1202)<br>Pfam-B_23300 (release 10.0). This family consists of several hypothetical bacterial proteins of around 335 residues in length. Members of this family are found exclusively in Escherichia coli and Salmonella species and are often referred to as YggM proteins. The function of this family is unknown.. 
+PF06718 Protein of unknown function (DUF1203)<br>Pfam-B_23313 (release 10.0). This family consists of several hypothetical bacterial proteins of around 155 residues in length. Family members are present in Rhizobium, Agrobacterium and Streptomyces species.. 
+PF06719 AraC_N-term; <br>AraC-type transcriptional regulator N-terminus. Pfam-B_16798 (release 10.0). This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains  . This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating  . All family members contain the Pfam:PF00165 domain.. 
+PF06720 Bacteriophage phi-29 early protein GP16.7<br>Pfam-B_23362 (release 10.0). This family consists of several bacteriophage phi-29 early protein GP16.7 sequences of around 130 residues in length. The function of this family is unknown.. 
+PF06721 Protein of unknown function (DUF1204)<br>Pfam-B_16832 (release 10.0). This family represents the C-terminus of a number of Arabidopsis thaliana hypothetical proteins of unknown function. Family members contain a conserved DFD motif.. 
+PF06722 Protein of unknown function (DUF1205)<br>Pfam-B_16780 (release 10.0). This family represents a conserved region of unknown function within bacterial glycosyl transferases. Many family members contain Pfam:PF03033.. 
+PF06723 MreB/Mbl protein<br>Pfam-B_471 (release 10.0). This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl  .. 
+PF06724 Domain of Unknown Function (DUF1206)<br>This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.. 
+PF06725 3D domain<br>This short presumed domain contains three conserved aspartate residues, hence the name 3D. It has been shown to be part of the catalytic double psi beta barrel domain of MltA  .. 
+PF06726 Bladder cancer-related protein BC10<br>Wood V, Moxon SJ, Coggill PC. This family consists of a series of short proteins of around 90 residues in length. The human protein Swiss:O60629 or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs)  . The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript.  All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues  . The function of this family is unknown.. 
+PF06727 Protein of unknown function (DUF1207)<br>Pfam-B_23454 (release 10.0). This family consists of a number of hypothetical bacterial proteins of around 410 residues in length which seem to be specific to Chlamydia species. The function of this family is unknown.. 
+PF06728 GPI transamidase subunit PIG-U<br>Pfam-B_7677 (release 9.0). Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI  . . 
+PF06729 NRIF3;<br>Kinetochore component, CENP-R. Pfam-B_23665 (release 10.0). This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression  . CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis [2,3].. 
+PF06730 DUF1208;<br>Moxon SJ, Eberhardt R. Pfam-B_23546 (release 10.0). This family of proteins has a role in embryogenesis. During embryogenesis it is essential for ectoderm and axial mesoderm development  . It may regulate cell proliferation and apoptosis  .. 
+PF06732 Pescadillo N-terminus<br>Pfam-B_77615 (release 9.0). This family represents the N-terminal region of Pescadillo. Pescadillo protein localises to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest  . This family is often found in conjunction with a Pfam:PF00533 domain.. 
+PF06733 DEAD_2<br>Pfam-B_1713 (release 10.0). This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast  .. 
+PF06734 UL97<br>Pfam-B_1747 (release 10.0). This family represents a conserved region within viral UL97 phosphotransferases. UL97 participates in the phosphorylation of the nucleoside analog ganciclovir (GCV) to produce GCV-monophosphate  .. 
+PF06736 Protein of unknown function (DUF1211)<br>Pfam-B_2594 (release 10.0). This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.. 
+PF06737 Transglycosylase-like domain<br>This family of proteins are very likely to act as transglycosylase enzymes related to Pfam:PF00062 and Pfam:PF01464. These other families are weakly matched by this family, and include the known active site residues.. 
+PF06738 Protein of unknown function (DUF1212)<br>Pfam-B_1646 (release 10.0). This family represents a conserved region within a number of hypothetical membrane proteins of unknown function found in eukaryotes, bacteria and archaea.. 
+PF06739 Beta-propeller repeat<br>This family is related to Pfam:PF00400 and is  likely to also form a beta-propeller. SBBP stands for Seven Bladed Beta Propeller.. 
+PF06740 Protein of unknown function (DUF1213)<br>Pfam-B_2177 (release 10.0). This family represents a short conserved repeat within Drosophila melanogaster proteins of unknown function. Approximately 50 copies of this repeat are present in each protein.. 
+PF06741 Ataxin-2-like; Ataxin-2_N; <br>Pfam-B_2543 (release 10.0). This domain is found associated with Lsm domain  .. 
+PF06742 Protein of unknown function (DUF1214)<br>Pfam-B_2721 (release 10.0). This family represents the C-terminal region of several hypothetical proteins of unknown function. Family members are mostly bacterial, but a few are also found in eukaryotes and archaea.. 
+PF06743 FAST_Leu-rich;<br>FAST kinase-like protein, subdomain 1. Vella Briffa B, Fenech M. Pfam-B_2858 (release 10.0). This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis  . Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.. 
+PF06744 Protein of unknown function (DUF1215)<br>Pfam-B_2952 (release 10.0). This family represents a conserved region situated towards the C-terminal end of several hypothetical bacterial proteins of unknown function. A few members resemble the ImcF protein, which has been proposed   to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells line and increased conjugation frequency.. 
+PF06745 KaiC<br>Pfam-B_2234 (release 10.0). This family represents a conserved region within bacterial and archaeal proteins, most of which are hypothetical. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria  .. 
+PF06746 Protein of unknown function (DUF1216)<br>Pfam-B_3048 (release 10.0). This family represents a conserved region, within Arabidopsis thaliana proteins, of unknown function. Family members sometimes contain more than one copy.It has been reported that this domain will be found in other Brassicaceae.. 
+PF06747 CHCH domain<br>Westerman BA, Poutsma A, Steegers E, Oudejans CBM. we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterised proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesise the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation  . Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit  . The CHCH domain was previously called DUF657  .. 
+PF06748 Protein of unknown function (DUF1217)<br>Pfam-B_3199 (release 10.0). This family represents a conserved region that is found within bacterial proteins, most of which are hypothetical. Some members contain multiple copies.. 
+PF06749 Protein of unknown function (DUF1218)<br>Pfam-B_3286 (release 10.0). This family contains hypothetical plant proteins of unknown function. Family members contain a number of conserved cysteine residues.. 
+PF06750 Bacterial Peptidase A24 N-terminal domain<br>This family is found at the N-terminus of the pre-pilin peptidases (Pfam:PF01478). It's function has not been specifically determined; however some of the family have been characterised as bifunctional ( ), and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in  , but their role was incorrectly ascribed. . 
+PF06751 Ethanolamine ammonia lyase large subunit (EutB)<br>Pfam-B_6325 (release 10.0). This family consists of several bacterial ethanolamine ammonia lyase large subunit (EutB) proteins (EC:4.3.1.7). Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia. The enzyme is a heterodimer composed of subunits of Mr approximately 55,000 (EutB) and 35,000 (EutC)  .  . 
+PF06752 E_Pc_C-term; <br>Enhancer of Polycomb C-terminus. Pfam-B_16811 (release 10.0). This family represents the C-terminus of eukaryotic enhancer of polycomb  proteins, which have roles in heterochromatin formation  . This family contains several conserved motifs.. 
+PF06753 Bradykinin<br>Pfam-B_7085 (release 10.0). This family consists of several bradykinin sequences. The skins of anuran amphibians, in addition to mucus glands, contain highly specialised poison glands, which, in reaction to stress or attack, exude a complex noxious cocktail of biologically active molecules. These secretions often contain a plethora of peptides among which bradykinin or structural variants have been identified  .. 
+PF06754 Phosphonate metabolism protein PhnG<br>Pfam-B_6667 (release 10.0). This family consists of several bacterial phosphonate metabolism protein PhnG sequences. In Escherichia coli, the phn operon encodes proteins responsible for the uptake and breakdown of phosphonates. The exact function of PhnG is unknown, however it is thought likely that along with six other proteins PhnG makes up the the C-P (carbon-phosphorus) lyase  .. 
+PF06755 Protein of unknown function (DUF1219)<br>Pfam-B_4928 (release 10.0). This family consists of several hypothetical proteins which seem to be specific to the Enterobacteria Escherichia coli and Shigella flexneri. Family members are often known as YeeV proteins and are around 125 residues in length. The function of this family is unknown.. 
+PF06756 S19_C-term; <br>Chorion protein S19 C-terminal. Pfam-B_16839 (release 10.0). This family represents the C-terminal region of eukaryotic chorion protein S19. In Drosophilidae, the S19 gene is known to form part of an autosomal cluster that also contains s16, s15 and s18  . Note that members of this family contain a conserved PVA motif, and many contain Pfam:PF03964.. 
+PF06757 Insect allergen related repeat, nitrile-specifier detoxification<br>Pfam-B_5947 (release 10.0). This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain  .. 
+PF06758 Repeat of unknown function (DUF1220)<br>Pfam-B_6292 (release 10.0). 
+PF06760 Protein of unknown function (DUF1221)<br>Pfam-B_16837 (release 10.0). This is a family of plant proteins, most of which are hypothetical and of unknown function. All members contain the Pfam:PF00069 domain, suggesting that they may possess kinase activity.. 
+PF06761 ImcF-related; <br>Intracellular multiplication and human macrophage-killing. Pfam-B_3476 (release 10.0). This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed   to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.. 
+PF06762 DUF1222;<br>Lipase maturation factor. Vella Briffa B, Eberhardt R. Pfam-B_3454 (release 10.0). This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [1,2]. The precise role of LMF1 in lipase folding has yet to be determined  .. 
+PF06763 Prophage minor tail protein Z (GPZ)<br>Pfam-B_6085 (release 10.0). This family consists of several prophage minor tail protein Z like sequences from Escherichia coli, Salmonella typhimurium and Lambda-like bacteriophages.. 
+PF06764 Protein of unknown function (DUF1223)<br>Pfam-B_6655 (release 10.0). This family consists of several hypothetical proteins of around 250 residues in length which are found in both plants and bacteria. The function of this family is unknown.. 
+PF06766 Fungal hydrophobin<br>Pfam-B_3587 (release 10.0). This is a family of fungal hydrophobins that seems to be restricted to ascomycetes. These are small, moderately hydrophobic extracellular proteins that have eight cysteine residues arranged in a strictly conserved motif. Hydrophobins are generally found on the outer surface of conidia and of the hyphal wall, and may be involved in mediating contact and communication between the fungus and its environment  . Note that some family members contain multiple copies.. 
+PF06767 Sif protein<br>Pfam-B_7884 (release 10.0). This family consists of several SifA and SifB and SseJ proteins which seem to be specific to the Salmonella species. SifA, SifB and SseJ have been demonstrated to localise to the Salmonella-containing vacuole (SCV) and to Salmonella-induced filaments (Sifs). Trafficking of SseJ and SifB away from the SCV requires the SPI-2 effector SifA. SseJ trafficking away from the SCV along Sifs is unnecessary for its virulence function  .. 
+PF06769 DUF1224; <br>Plasmid encoded toxin Txe. Pfam-B_7662 (release 10.0). The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair.  When the plasmid is lost, the antitoxin (Axe) is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth  . This family contains many hypothetical proteins. This domain forms complexes with Axe antitoxins containing Pfam:PF02604.. 
+PF06770 Actin-rearrangement-inducing factor (Arif-1)<br>Pfam-B_6086 (release 10.0). This family consists of several Nucleopolyhedrovirus actin-rearrangement-inducing factor (Arif-1) proteins. In response to Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) infection, a sequential rearrangement of the actin cytoskeleton occurs this is induced by Arif-1  . Arif-1 is tyrosine phosphorylated and is located at the plasma membrane as a component of the actin rearrangement-inducing complex  .. 
+PF06771 1111; Desmo_N-term; <br>Viral Desmoplakin N-terminus. Pfam-B_3693 (release 10.0). This family represents the N-terminus of viral desmoplakin. Desmoplakin is a component of mature desmosomes, which are the main adhesive junctions in epithelia and cardiac muscle. Desmoplakin is also essential for the maturation of adherens junctions  . Note that many family members are hypothetical.. 
+PF06772 Bacterial low temperature requirement A protein (LtrA)<br>Pfam-B_8368 (release 10.0). This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes  .. 
+PF06773 Bim protein N-terminus<br>Pfam-B_8427 (release 10.0). This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death  .. 
+PF06775 DUF1226; <br>Putative adipose-regulatory protein (Seipin). Pfam-B_8703 (release 10.0). Seipin is a protein of approximately 400 residues, in humans, which is the product of a gene homologous to the murine guanine nucleotide-binding protein (G protein) gamma-3 linked gene.  This gene is implicated in the regulation of body fat distribution and insulin resistance and particularly in the auto-immune disease Berardinelli-Seip congenital lipodystrophy type 2. Seipin has no similarity with other known proteins or consensus motifs that might predict its function, but it is predicted to contain two transmembrane domains at residues 28-49 and 237-258, in human, and a third transmembrane domain might be present at residues 155-173. Seipin may also be implicated in Silver spastic paraplegia syndrome and distal hereditary motor neuropathy type V  .. 
+PF06776 Invasion associated locus B (IalB) protein<br>Pfam-B_3703 (release 10.0). This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions  . The role of this protein in other bacterial species is unknown.. 
+PF06777 Protein of unknown function (DUF1227)<br>Pfam-B_3660 (release 10.0). This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).. 
+PF06778 Chlorite dismutase<br>Pfam-B_3770 (release 10.0). This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyses the disproportionation of chlorite into chloride and oxygen  . Note that many family members are hypothetical proteins.. 
+PF06779 Protein of unknown function (DUF1228)<br>Pfam-B_5646 (release 10.0). This family represents the N-terminus of several putative bacterial membrane proteins, which may be sugar transporters. Note that many family members are hypothetical proteins.. 
+PF06780 Erp_C-term; <br>Erp protein C-terminus. Pfam-B_4561 (release 10.0). This family represents the C-terminus of bacterial Erp proteins that seem to be specific to Borrelia burgdorferi (a causative agent of Lyme disease). Borrelia Erp proteins are particularly heterogeneous, which might enable them to interact with a wide variety of host components  .. 
+PF06781 Uncharacterised protein family (UPF0233)<br>
+PF06782 Uncharacterised protein family (UPF0236)<br>
+PF06783 Uncharacterised protein family (UPF0239)<br>
+PF06784 Uncharacterised protein family (UPF0240)<br>
+PF06785 Uncharacterised protein family (UPF0242)<br>
+PF06786 Uncharacterised protein family (UPF0253)<br>
+PF06787 Uncharacterised protein family (UPF0254)<br>
+PF06788 Uncharacterised protein family (UPF0257)<br>
+PF06789 Uncharacterised protein family (UPF0258)<br>
+PF06790 Uncharacterised protein family (UPF0259)<br>
+PF06791 Prophage tail length tape measure protein<br>Pfam-B_3868 (release 10.0). This family represents a conserved region located towards the N-terminal end of prophage tail length tape measure protein (TMP). TMP is important for assembly of phage tails and involved in tail length determination. Mutated forms TMP cause tail fibres to be shortened  .. 
+PF06792 Uncharacterised protein family (UPF0261)<br>
+PF06793 Uncharacterised protein family (UPF0262)<br>
+PF06794 Uncharacterised protein family (UPF0270)<br>
+PF06795 Erythrovirus X protein<br>Pfam-B_9167 (release 10.0). This family consists of several Erythrovirus X proteins which seem to be found exclusively in human parvovirus and human erythrovirus. The function of this family is unknown.. 
+PF06796 Periplasmic nitrate reductase protein NapE<br>Pfam-B_9066 (release 10.0). This family consists of several bacterial periplasmic nitrate reductase NapE proteins. Seven genes, napKEFDABC, encoding the periplasmic nitrate reductase system were cloned from the denitrifying phototrophic bacterium Rhodobacter sphaeroides f. sp. denitrificans IL106. NapE is thought to be a transmembrane protein  .. 
+PF06797 Protein of unknown function (DUF1229)<br>Pfam-B_9402 (release 10.0). This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.. 
+PF06798 PrkA serine protein kinase C-terminal domain<br>Pfam-B_3917 (release 10.0). This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This family corresponds to the C-terminal domain  .. 
+PF06799 Protein of unknown function (DUF1230)<br>Pfam-B_9232 (release 10.0). This family consists of several hypothetical plant and photosynthetic bacterial proteins of around 160 residues in length. The function of this family is unknown although looking at the species distribution the protein may play a part in photosynthesis.. 
+PF06800 Sugar transport protein<br>Pfam-B_4126 (release 10.0). This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins  , ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes.. 
+PF06802 Protein of unknown function (DUF1231)<br>Pfam-B_9856 (release 10.0). This family consists of several Orthopoxvirus specific proteins predominantly of around 340 residues in length. This family contains both B17 and B15 proteins, the function of which are unknown.. 
+PF06803 Protein of unknown function (DUF1232)<br>Pfam-B_4265 (release 10.0). This family represents a conserved region of approximately 60 residues within a number of hypothetical bacterial and archaeal proteins of unknown function.. 
+PF06804 NlpB/DapX lipoprotein<br>Pfam-B_10405 (release 10.0). This family consists of a number of bacterial lipoproteins often known as NlpB or DapX. This lipoprotein is detected in outer membrane vesicles in Escherichia coli and appears to be nonessential  .. 
+PF06805 Bacteriophage lambda tail assembly protein I<br>Moxon SJ, Iyer LM, Burroughs AM, Aravind L. Pfam-B_7725 (release 10.0). This family consists of tail assembly proteins from lambdoid and T1 phages and related prophages, e.g. the tail assembly protein I  (TAPI). Members of this family contain a core ubiquitin fold domain   . The exact function of TAPI is not clear but  it is not incorporated into the mature tail. Gene neighborhoods  reveal that TAPI co-occurs with genes encoding the host-specificity  protein TapJ, and TapK, which contains a JAB metallopeptidase fused  to an NlpC/P60  peptidase. It is proposed that the TAPI protein is  processed by the  peptidase domains of TapK  .. 
+PF06806 Putative excisionase (DUF1233)<br>Pfam-B_9240 (release 10.0). This family consists of several putative phage excisionase proteins of around 80 residues in length.. 
+PF06807 Pre-mRNA cleavage complex II protein Clp1<br>Pfam-B_9787 (release 10.0). This family consists of several pre-mRNA cleavage complex II Clp1 (or HeaB) proteins. Six different protein factors are required in vitro for 3' end formation of mammalian pre-mRNAs by endonucleolytic cleavage and polyadenylation. Clp1 is a subunit of cleavage complex IIA, which is required for cleavage, but not for polyadenylation of pre-mRNA  .. 
+PF06808 DctM-like transporters<br>Pfam-B_4075 (release 10.0). This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers  . Note that many family members are hypothetical proteins.. 
+PF06809 Neural proliferation differentiation control-1 protein (NPDC1)<br>Pfam-B_10407 (release 10.0). This family consists of several neural proliferation differentiation control-1 (NPDC1) proteins. NPDC1 plays a role in the control of neural cell proliferation and differentiation. It has been suggested that NPDC1 may be involved in the development of several secretion glands. This family also contains the C-terminal region of the C. elegans protein CAB-1 (Swiss:Q93249) which is known to interact with AEX-3  .. 
+PF06810 Phage minor structural protein GP20<br>Pfam-B_8431 (release 10.0). This family consists of several phage minor structural protein GP20 sequences of around 180 residues in length. The function of this family is unknown.. 
+PF06812 ImpA-rel_N-term; <br>ImpA-related N-terminal. Pfam-B_4308 (release 10.0). This family represents a conserved region located towards the N-terminal end of ImpA and related proteins. ImpA is an inner membrane protein, which has been suggested to be involved with proteins that are exported and associated with colony variations in Actinobacillus actinomycetemcomitans  . Note that many family members are hypothetical proteins.. 
+PF06813 Nodulin-like<br>Pfam-B_4440 (release 10.0). This family represents a conserved region within plant nodulin-like proteins.. 
+PF06814 Lung seven transmembrane receptor<br>Pfam-B_4367 (release 10.0). This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.. 
+PF06815 rvt_connect;<br>Reverse transcriptase connection domain. This domain is known as the connection domain. This domain lies between the thumb and palm domains  .. 
+PF06816 NOD; NOD1; <br>NOTCH  signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be  elucidated.. 
+PF06817 rvt_thumb;<br>Reverse transcriptase thumb domain. This domain is known as the thumb domain. It is composed of a four helix bundle  .. 
+PF06818 Fez1<br>Pfam-B_4593 (release 10.0). This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5  . There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth  . Note that some family members contain more than one copy of this region.. 
+PF06819 Archaeal Peptidase A24 C-terminal Domain<br>This region is of unknown function but is found in some archaeal Pfam:PF01478. It is predicted to be of mixed alpha/beta secondary structure by JPred.. 
+PF06820 Tail_fib_C-term; <br>Putative prophage tail fibre C-terminus. Pfam-B_5030 (release 10.0). This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.. 
+PF06821 DUF1234;<br>Vella Briffa B, Eberhardt R. Pfam-B_4941 (release 10.0). Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile  .\.       This family has an alpha-beta hydrolase fold [2,3]. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family  .. 
+PF06822 Protein of unknown function (DUF1235)<br>Pfam-B_4988 (release 10.0). This family contains a number of viral proteins of unknown function.. 
+PF06823 Protein of unknown function (DUF1236)<br>Pfam-B_5056 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function. Some family members contain more than one copy of the region represented by this family.. 
+PF06824 Protein of unknown function (DUF1237)<br>Pfam-B_4981 (release 10.0). This family contains a number of hypothetical proteins of about 450 residues in length. Their function is unknown, and most are bacterial. However, structurally this family is part of the 6 hairpin glycosidase superfamily, suggesting a glycosyl hydrolase function.. 
+PF06825 Heat shock factor binding protein 1<br>Pfam-B_20266 (release 10.0). Heat shock factor binding protein 1 (HSBP1) appears to be a negative regulator of the heat shock response  .. 
+PF06826 Predicted Permease Membrane Region<br>This family represents five transmembrane helices that are normally found flanking (five either side) a pair of Pfam:PF02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the Pfam:PF02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter ( ). In  conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalysed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.. 
+PF06827 Zinc finger found in FPG and IleRS<br>This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.. 
+PF06830 Root cap<br>Pfam-B_5867 (release 10.0). The cells at the periphery of the root cap are continuously sloughed off from the root into the mucilage, and are thought to be programmed to die  .This family represents a conserved region approximately 60 residues in length within plant root cap proteins, which may be involved in the process.. 
+PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain<br>Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain  .. 
+PF06832 Penicillin-Binding Protein C-terminus Family<br>This conserved region of approximately 90 residues is found in a sub-group of bacterial Penicillin-Binding Proteins (PBPs). A variable length loop region separates this region from the transpeptidase unit (Pfam:PF00905). It is predicted by PROF to be an all beta fold.. 
+PF06833 Malonate decarboxylase gamma subunit (MdcE)<br>Pfam-B_10907 (release 10.0). This family consists of several bacterial malonate decarboxylase gamma subunit proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcD and E together probably function as malonyl-S-ACP decarboxylase  .  . 
+PF06834 TraU protein<br>Pfam-B_10708 (release 10.0). This family consists of several bacterial TraU proteins. TraU appears to be more essential to conjugal DNA transfer than to assembly of pilus filaments  .. 
+PF06835 DUF1239;<br>Lipopolysaccharide-assembly, LptC-related. Pfam-B_11065 (release 10.0). This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space.. 
+PF06836 Protein of unknown function (DUF1240)<br>Pfam-B_11130 (release 10.0). This family consists of a number of hypothetical putative membrane proteins which seem to be specific to Yersinia pestis. The function of this family is unknown.. 
+PF06837 Fijivirus P9-2 protein<br>Pfam-B_11357 (release 10.0). This family consists of several Fijivirus specific P9-2 proteins from Rice black streaked dwarf virus (RBSDV) and Fiji disease virus. The function of this family is unknown.. 
+PF06838 Alum_res;<br>Methionine gamma-lyase . Vella Briffa B, Haft D. Pfam-B_5307 (release 10.0). This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.. 
+PF06839 GRF zinc finger<br>This presumed zinc binding domain is found in a variety of DNA-binding proteins.  It seems likely that this domain is involved in nucleic acid binding.  It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to Pfam:PF01396.. 
+PF06840 Protein of unknown function (DUF1241)<br>Pfam-B_11380 (release 10.0). This family consists of several programmed cell death 10 protein (PDCD10 or TFAR15) sequences. The function of this family is unknown.. 
+PF06841 T4_Gp19; <br>T4-like virus tail tube protein gp19. Pfam-B_11507 (release 10.0). This family consists of several tail tube protein gp19 sequences from the T4-like viruses [1,2].  This famiyl also contains bacterial members which suggest lateral transfer of genes.. 
+PF06842 Protein of unknown function (DUF1242)<br>Pfam-B_11544 (release 10.0). This family consists of a number of eukaryotic proteins of around 72 residues in length. The function of this family is unknown.. 
+PF06844 Protein of unknown function (DUF1244)<br>Pfam-B_11743 (release 10.0). This family consists of several short bacterial proteins of around 100 residues in length. The function of this family is unknown.. 
+PF06847 Archaeal Peptidase A24 C-terminus Type II<br>This region is of unknown function but is found in some archaeal Pfam:PF01478. It is predicted to be of mixed alpha/beta secondary structure by Prof.. 
+PF06848 Disaggregatase related repeat<br>Moxon SJ, Mistry J, Adindla S. Pfam-B_11958 (release 10.0). This family consists of several repeats which seem to be specific to the Methanosarcina archaea species and are often found in multiple copies in disaggregatase proteins. Members of this family are also found in single copies in several hypothetical proteins.  This repeat is also known as DNRLRE repeat and is predicted form a mainly beta-strand structure with two alpha-helices [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  It is found in some cell surface proteins. . 
+PF06849 Protein of unknown function (DUF1246)<br>Pfam-B_5448 (release 10.0). This family represents the N-terminus of a number of hypothetical archaeal proteins of unknown function.. 
+PF06850 PHB_depo_C-term; <br>PHB de-polymerase C-terminus. Pfam-B_5697 (release 10.0). This family represents the C-terminus of bacterial poly(3-hydroxybutyrate) (PHB) de-polymerase. This degrades PHB granules to oligomers and monomers of 3-hydroxy-butyric acid.. 
+PF06851 Protein of unknown function (DUF1247)<br>Pfam-B_5762 (release 10.0). This family contains a number of hypothetical viral proteins of unknown function approximately 200 residues long.. 
+PF06852 Protein of unknown function (DUF1248)<br>Pfam-B_5811 (release 10.0). This family represents a conserved region within a number of proteins of unknown function that seem to be specific to C. elegans. Note that some family members contain more than one copy of this region.. 
+PF06853 Protein of unknown function (DUF1249)<br>Pfam-B_11475 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.. 
+PF06854 Bacteriophage Gp15 protein<br>Pfam-B_11759 (release 10.0). This family consists of bacteriophage Gp15 proteins and related bacterial sequences. The function of this family is unknown. 
+PF06855 Protein of unknown function (DUF1250)<br>Pfam-B_11942 (release 10.0). This family consists of several short hypothetical bacterial proteins of around 70 residues in length. Members of this family seem to all belong to the order Bacillales or Lactobacillales. The function of this family is unknown.. 
+PF06856 Protein of unknown function (DUF1251)<br>Pfam-B_12000 (release 10.0). This family consists of the N-terminal region of several hypothetical Nucleopolyhedrovirus proteins of unknown function.. 
+PF06857 MdcD;<br>Malonate decarboxylase delta subunit (MdcD). Pfam-B_12010 (release 10.0). This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins.  Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit  . The family also contains the CitD family of citrate lyase acyl carrier proteins.. 
+PF06858 Nucleolar GTP-binding protein 1 (NOG1)<br>Pfam-B_5853 (release 10.0). This family represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). In S. cerevisiae, the NOG1 gene has been shown to be essential for cell viability, suggesting that NOG1 may play an important role in nucleolar functions  . Family members include eukaryotic, bacterial and archaeal proteins.. 
+PF06859 Bicoid-interacting protein 3 (Bin3)<br>Pfam-B_5564 (release 10.0). This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation  . Note that family members contain a conserved HLN motif.. 
+PF06861 BALF1 protein<br>Pfam-B_12069 (release 10.0). This family consists of several BALF1 proteins which seem to be specific to the Lymphocryptoviruses. BALF1, inhibits the antiapoptotic activity of EBV BHRF1 and of KSBcl-2  .. 
+PF06862 Protein of unknown function (DUF1253)<br>Pfam-B_6227 (release 10.0). This family represents the C-terminal portion (approximately 500 residues) of several hypothetical eukaryotic proteins of unknown function.. 
+PF06863 Protein of unknown function (DUF1254)<br>Pfam-B_5911 (release 10.0). This family represents a conserved region about 130 residues long within hypothetical proteins of unknown function. Family members include eukaryotic, bacterial and archaeal proteins.. 
+PF06864 Pilin accessory protein (PilO)<br>Pfam-B_12430 (release 10.0). This family consists of several enterobacterial PilO proteins. The function of PilO is unknown although it has been suggested that it is a cytoplasmic protein in the absence of other Pil proteins, but PilO protein is translocated to the outer membrane in the presence of other Pil proteins. Alternatively, PilO protein may form a complex with other Pil protein(s). PilO has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body  . This family does not seem to be related to Pfam:PF04350.. 
+PF06865 Protein of unknown function (DUF1255)<br>Pfam-B_12498 (release 10.0). This family consists of several conserved hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown. 
+PF06866 Protein of unknown function (DUF1256)<br>Pfam-B_12377 (release 10.0). This family consists of several uncharacterised bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.. 
+PF06868 Protein of unknown function (DUF1257)<br>Pfam-B_5975 (release 10.0). This family contains hypothetical proteins of unknown function that are approximately 120 residues long. Family members include eukaryotic and bacterial proteins.. 
+PF06869 Protein of unknown function (DUF1258)<br>Pfam-B_6065 (release 10.0). This family represents a conserved region approximately 260 residues long within a number of hypothetical proteins of unknown function that seem to be specific to C. elegans. Note that this family contains a number of conserved cysteine and histidine residues.. 
+PF06870 A49-like RNA polymerase I associated factor <br>Pfam-B_20222 (release 10.0). Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures.  Deletion analysis of the fusion yeast  homolog indicate that only the C-terminal two thirds are required for function.  Transcript analysis has demonstrated that A49 is maximising transcription of ribosomal DNA  .. 
+PF06871 DUF1259; <br>Pfam-B_13298 (release 10.0). This family consists of several TraH proteins which seem to be specific to Agrobacterium and Rhizobium species. This protein is thought to be involved in conjugal transfer but its function is unknown. This family does not appear to be related to Pfam:PF06122.. 
+PF06872 EspG protein<br>Pfam-B_13549 (release 10.0). This family consists of several EspG like proteins from Citrobacter rodentium and Escherichia coli. EspG is secreted by the type III secretory system and is translocated into host epithelial cells. EspG is homologous with Shigella flexneri protein VirA and can rescue invasion in a Shigella virA mutant, indicating that these proteins are functionally equivalent in Shigella.  EspG plays an accessory but as yet undefined role in EPEC virulence that may involve intestinal colonisation  .. 
+PF06873 Cell surface immobilisation antigen SerH<br>Pfam-B_13151 (release 10.0). This family consists of several cell surface immobilisation antigen SerH proteins which seem to be specific to Tetrahymena thermophila. The SerH locus of Tetrahymena thermophila is one of several paralogous loci with genes encoding variants of the major cell surface protein known as the immobilisation antigen (i-ag)  . . 
+PF06874 Firmicut_FBPase; <br>Firmicute fructose-1,6-bisphosphatase. Pfam-B_13194 (release 10.0). This family consists of several bacterial fructose-1,6-bisphosphatase proteins (EC:3.1.3.11) which seem to be specific to phylum Firmicutes. Fructose-1,6-bisphosphatase (FBPase) is a well known enzyme involved in gluconeogenesis  . This family does not seem to be structurally related to Pfam:PF00316.. 
+PF06875 Plethodontid receptivity factor PRF<br>Pfam-B_13241 (release 10.0). This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity  .. 
+PF06876 Plant self-incompatibility response (SCRL) protein<br>Pfam-B_13253 (release 10.0). This family consists of several Plant self-incompatibility response (SCRL) proteins. The male component of the self-incompatibility response in Brassica has been shown to be encoded by the S locus cysteine-rich gene (SCR). SCR is related, at the sequence level, to the pollen coat protein (PCP) gene family whose members encode small, cysteine-rich proteins located in the proteo-lipidic surface layer (tryphine) of Brassica pollen grains  .. 
+PF06877 DUF1260;<br>Regulator of ribonuclease activity B. Pfam-B_13601 (release 10.0). This family of proteins regulate mRNA abundance by binding to RNaseE and inhibiting its endonucleolytic activity [1-2]. A subset of these proteins are predicted to function as immunity proteins  .. 
+PF06878 Pkip-1 protein<br>Pfam-B_13784 (release 10.0). This family consists of several Pkip-1 proteins which seem to be specific to Nucleopolyhedroviruses. The function of this family is unknown although it has been found that Pkip-1 is not essential for virus replication in cell culture or by in vivo intrahaemocoelic injection  .  . 
+PF06880 Protein of unknown function (DUF1262)<br>Pfam-B_6733 (release 10.0). This family represents a conserved region within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that some family members contain more than one copy of this region.. 
+PF06881 RNA polymerase II transcription factor SIII (Elongin) subunit A<br>Pfam-B_6598 (release 10.0). This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin  .. 
+PF06882 Protein of unknown function (DUF1263)<br>Pfam-B_6668 (release 10.0). This family represents a conserved region located towards the C-terminus of a number proteins of unknown function that seem to be specific to Oryza sativa.. 
+PF06883 RNA polymerase I, Rpa2 specific domain <br>Pfam-B_4721 (release 10.0). This domain is found between domain 3 (Pfam:PF04565) and domain 5  (Pfam:PF04565), but shows no homology to domain 4 of Rpb2.  The external  domains in multisubunit RNA polymerase (those most distant from the  active site) are known to demonstrate more sequence variability  .. 
+PF06884 Protein of unknown function (DUF1264)<br>Pfam-B_6839 (release 10.0). This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 200 residues long. Some family members are annotated as putative lipoproteins.. 
+PF06886 Targeting protein for Xklp2 (TPX2)<br>Pfam-B_6863 (release 10.0). This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity  . TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way  .. 
+PF06887 Protein of unknown function (DUF1265)<br>Vella Briffa B, Pollington JE. Pfam-B_7101 (release 10.0). This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be restricted to C. elegans. The GO annotation for this protein indicate that its a protein involved in nematode larval development and has a positive regulation on growth rate.. 
+PF06888 Putative Phosphatase<br>Pfam-B_7115 (release 10.0). This family contains a number of putative eukaryotic acid phosphatases. Some family members represent the products of the PSI14 phosphatase family in Lycopersicon esculentum (Tomato)  .. 
+PF06889 Protein of unknown function (DUF1266)<br>Pfam-B_13878 (release 10.0). This family consists of several hypothetical bacterial proteins of around 235 residues in length. Members of this family seem to be found exclusively in the Enterobacteria Salmonella typhimurium and Escherichia coli. The function of this family is unknown.. 
+PF06890 Bacteriophage Mu Gp45 protein<br>Pfam-B_10848 (release 10.0). This family consists of Bacteriophage Mu Gp45 related proteins from both phages and bacteria. The function of this family is unknown although it has been suggested that family members may be involved in baseplate assembly.. 
+PF06891 P2 phage tail completion protein R (GpR)<br>Pfam-B_10918 (release 10.0). This family consists of P2 phage tail completion protein R (GpR) like sequences. GpR is thought to be a tail completion protein which is essential for stable head joining  .. 
+PF06892 Phage regulatory protein CII (CP76)<br>Pfam-B_13444 (release 10.0). This family consists of several phage regulatory protein CII (CP76) sequences which are thought to be DNA binding proteins which are involved in the establishment of lysogeny  .. 
+PF06894 Bacteriophage lambda minor tail protein (GpG)<br>Pfam-B_11957 (release 10.0). This family consists of Bacteriophage lambda minor tail protein G and related sequences. The role of GpG in tail assembly is not known  .. 
+PF06896 Protein of unknown function (DUF1268)<br>Pfam-B_11819 (release 10.0). This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.. 
+PF06897 Protein of unknown function (DUF1269)<br>Pfam-B_14034 (release 10.0). This family consists of several bacterial and archaeal proteins of around 200 residues in length. The function of this family is unknown. The family carries a repeated glycine-zipper sequence- motif, GxxxGxxxG, where the x following the G is frequently found to be an alanine. As glycine-zippers occur in membrane proteins, this family is likely to be found spanning a membrane.. 
+PF06898 Putative stage IV sporulation protein YqfD<br>Pfam-B_13823 (release 10.0). This family consists of several putative bacterial stage IV sporulation (SpoIV) proteins. YqfD of Bacillus subtilis (Swiss:P54469) is known to be essential for efficient sporulation although its exact function is unknown  .. 
+PF06899 WzyE protein<br>Pfam-B_13849 (release 10.0). This family consists of several WzyE proteins which appear to be specific to Enterobacteria. Members of this family are described as putative ECA polymerases this has been found to be incorrect  . The function of this family is unknown.. 
+PF06900 Protein of unknown function (DUF1270)<br>Pfam-B_13907 (release 10.0). This family consists of several hypothetical Staphylococcus aureus and phage proteins of 53 residues in length. The function of this family is unknown.. 
+PF06901 RTX iron-regulated protein FrpC<br>Pfam-B_14005 (release 10.0). This family consists of several RTX iron-regulated FrpC proteins which appear to be found exclusively in Neisseria meningitidis. FrpC has been shown to be related to the RTX family of bacterial cytotoxins. FrpC is found in the meningococcal outer membrane. The function of this family is unknown although it is thought to be a virulence factor  .. 
+PF06902 DUF1271;<br>Divergent 4Fe-4S mono-cluster. Pfam-B_13906 (release 10.0). Members of this family contain three highly conserved cysteine residues. This family includes proteins containing divergent domains which are most likely to bind to iron-sulfur clusters.. 
+PF06903 VirK protein<br>Pfam-B_13955 (release 10.0). This family consists of several bacterial VirK proteins of around 145 residues in length. The function of this family is unknown  .. 
+PF06904 Extensin-like protein C-terminus<br>Pfam-B_6925 (release 10.0). This family represents the C-terminus (approx. 120 residues) of a number of bacterial extensin-like proteins. Extensins are cell wall glycoproteins normally associated with plants, where they strengthen the cell wall in response to mechanical stress  . Note that many family members of this family are hypothetical.. 
+PF06905 FAIM; <br>Fas apoptotic inhibitory molecule (FAIM1). Pfam-B_13985 (release 10.0). This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology  .. 
+PF06906 Protein of unknown function (DUF1272)<br>Pfam-B_14128 (release 10.0). This family consists of several hypothetical bacterial proteins of around 80 residues in length. This family contains a number of conserved cysteine residues and its function is unknown.. 
+PF06907 Latexin<br>Pfam-B_14203 (release 10.0). This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat  .. 
+PF06908 Protein of unknown function (DUF1273)<br>Pfam-B_14270 (release 10.0). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.. 
+PF06910 Male enhanced antigen 1 (MEA1)<br>Pfam-B_14358 (release 10.0). This family consists of several mammalian male enhanced antigen 1 (MEA1) proteins. The Mea-1 gene is found to be localised in primary and secondary spermatocytes and spermatids, but the protein products are detected only in spermatids. Intensive transcription of Mea-1 gene and specific localisation of the gene product suggest that Mea-1 may play a important role in the late stage of spermatogenesis  . . 
+PF06911 Senescence-associated protein<br>Pfam-B_7525 (release 10.0). This family contains a number of plant senescence-associated proteins of approximately 450 residues in length. In Hemerocallis, petals have a genetically based program that leads to senescence and cell death approximately 24 hours after the flower opens, and it is believed that senescence proteins produced around that time have a role in this program  . This family extends to the higher vertebrates where the full-length protein is often a Spartin, associated with mitochondrial membranes and transportation along microtubules  .. 
+PF06912 Protein of unknown function (DUF1275)<br>Pfam-B_13896 (release 10.0). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although a few members are thought to be membrane proteins.. 
+PF06916 Protein of unknown function (DUF1279)<br>Pfam-B_7316 (release 10.0). This family represents the C-terminus (approx. 120 residues) of a number of eukaryotic proteins of unknown function.. 
+PF06917 Periplasmic pectate lyase<br>Pfam-B_14500 (release 10.0). This family consists of several Enterobacterial periplasmic pectate lyase proteins (EC:4.2.2.2). A major virulence determinant of the plant-pathogenic enterobacterium Erwinia chrysanthemi is the production of pectate lyase enzymes that degrade plant cell walls  .. 
+PF06918 Protein of unknown function (DUF1280)<br>Pfam-B_7457 (release 10.0). This family represents a conserved region approximately 200 residues long within a number of proteins of unknown function that seem to be specific to C. elegans.. 
+PF06919 Phage Gp30.7 protein<br>Pfam-B_14625 (release 10.0). This family consists of several phage Gp30.7 proteins of 121 residues in length. Family members seem to be exclusively from the T4-like viruses. The function of this family is unknown.. 
+PF06920 Dedicator of cytokinesis<br>Pfam-B_7154 (release 10.0). This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.. 
+PF06922 Citrus tristeza virus P13 protein<br>Pfam-B_14711 (release 10.0). This family consists of several Citrus tristeza virus (CTV) P13 13-kDa proteins. Citrus tristeza virus (CTV), a member of the closterovirus group, is one of the more complex single-stranded RNA viruses  . The function of this family is unknown.. 
+PF06923 Glucitol operon activator protein (GutM)<br>Pfam-B_14714 (release 10.0). This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes  .. 
+PF06924 Protein of unknown function (DUF1281)<br>Pfam-B_14730 (release 10.0). This family consists of several hypothetical enterobacterial proteins of around 170 residues in length. Members of this family are found in Escherichia coli, Salmonella typhimurium and Shigella species. The function of this family is unknown.. 
+PF06925 Monogalactosyldiacylglycerol (MGDG) synthase<br>Pfam-B_8075 (release 10.0). This family represents a conserved region of approximately 180 residues within plant and bacterial monogalactosyldiacylglycerol (MGDG) synthase (EC:2.4.1.46). In Arabidopsis, there are two types of MGDG synthase which differ in their N-terminal portion: type A and type B  .. 
+PF06926 Putative replisome organiser protein C-terminus<br>Pfam-B_6517 (release 10.0). This family represents the C-terminus (approximately 100 residues) of a putative replisome organiser protein in Lactococcus bacteriophages  .. 
+PF06929 Rotavirus VP3 protein<br>Pfam-B_14798 (release 10.0). This family consists of several Rotavirus specific VP3 proteins. VP3 is known to be a viral guanylyltransferase and is thought to posses methyltransferase activity and therefore VP3 is a predicted multifunctional capping enzyme  . . 
+PF06930 Protein of unknown function (DUF1282)<br>Pfam-B_14843 (release 10.0). This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.. 
+PF06931 Mastadenovirus E4 ORF3 protein<br>Pfam-B_14868 (release 10.0). This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon  .. 
+PF06932 Protein of unknown function (DUF1283)<br>Pfam-B_15035 (release 10.0). This family consists of several hypothetical proteins of around 115 residues in length which seem to be specific to Enterobacteria. The function of the family is unknown.. 
+PF06933 Special lobe-specific silk protein SSP160<br>Pfam-B_14947 (release 10.0). This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomus (Midge) species [1,2].. 
+PF06934 Fatty acid cis/trans isomerase (CTI)<br>Pfam-B_14967 (release 10.0). This family consists of several fatty acid cis/trans isomerase proteins which appear to be found exclusively in bacteria of the orders Vibrionales and Pseudomonadales. Cis/trans isomerase (CTI) catalyses the cis-trans isomerisation of esterified fatty acids in phospholipids, mainly cis-oleic acid (C(16:1,9)) and cis-vaccenic acid (C(18:1,11)), in response to solvents. The CTI protein has been shown to be involved in solvent resistance in Pseudomonas putida  .. 
+PF06935 Protein of unknown function (DUF1284)<br>Pfam-B_14822 (release 10.0). This family consists of several hypothetical bacterial and archaeal proteins of around 130 residues in length. The function of this family is unknown, although it is thought that they may be iron-sulphur binding proteins.. 
+PF06936 Selenoprotein S (SelS)<br>Pfam-B_15061 (release 10.0). This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types  . The function of this family is unknown.. 
+PF06937 EURL protein<br>Pfam-B_14914 (release 10.0). This family consists of several animal EURL proteins. EURL is preferentially expressed in chick retinal precursor cells as well as in the anterior epithelial cells of the lens at early stages of development. EURL transcripts are found primarily in the peripheral dorsal retina, i.e., the most undifferentiated part of the dorsal retina. EURL transcripts are also detected in the lens at stage 18 and remain abundant in the proliferating epithelial cells of the lens until at least day 11. The distribution pattern of EURL in the developing retina and lens suggest a role before the events leading to cell determination and differentiation  .  . 
+PF06938 Protein of unknown function (DUF1285)<br>Pfam-B_15060 (release 10.0). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. The structures revealed a conserved core with domain duplication and a superficial similarity for the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain- interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress.. 
+PF06939 Protein of unknown function (DUF1286)<br>Pfam-B_15105 (release 10.0). This family consists of several hypothetical archaeal proteins of around 120 residues in length. All members of this family seem to be Sulfolobus species specific. The function of this family is unknown.. 
+PF06940 Domain of unknown function (DUF1287)<br>Pfam-B_15116 (release 10.0). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. This family is related to Pfam:PF00877.. 
+PF06941 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)<br>Pfam-B_14848 (release 10.0). This family consists of several 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C (NT5C) proteins. 5'(3')-Deoxyribonucleotidase is a ubiquitous enzyme in mammalian cells whose physiological function is not known  . . 
+PF06942 GlpM protein<br>Pfam-B_15323 (release 10.0). This family consists of several bacterial GlpM membrane proteins. GlpM is a hydrophobic protein containing 109 amino acids. It is thought that GlpM may play a role in alginate biosynthesis in Pseudomonas aeruginosa  .. 
+PF06943 LSD1 zinc finger<br>Pfam-B_15249 (release 10.0). This family consists of several plant specific LSD1 zinc finger domains. Arabidopsis lsd1 mutants are hyper-responsive to cell death initiators and fail to limit the extent of cell death. Superoxide is a necessary and sufficient signal for cell death propagation. LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. LSD1 protein contains three zinc finger domains, defined by CxxCxRxxLMYxxGASxVxCxxC. It has been suggested that LSD1 defines a zinc finger protein subclass and that LSD1 regulates transcription, via either repression of a pro-death pathway or activation of an anti-death pathway, in response to signals emanating from cells undergoing pathogen-induced hypersensitive cell death  . . 
+PF06945 Protein of unknown function (DUF1289)<br>Moxon SJ, Eberhardt R. Pfam-B_15170 (release 10.0). This family consists of a number of hypothetical bacterial proteins.  The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N-terminus. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF06946 Phage holin<br>Pfam-B_15309 (release 10.0). This family consists of several Listeria bacteriophage holin proteins and  related bacterial sequences. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis  .. 
+PF06947 Protein of unknown function (DUF1290)<br>Pfam-B_15248 (release 10.0). This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.. 
+PF06949 Protein of unknown function (DUF1292)<br>Pfam-B_15310 (release 10.0). This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.. 
+PF06950 Protein of unknown function (DUF1293)<br>Pfam-B_15399 (release 10.0). This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.. 
+PF06951 Group XII secretory phospholipase A2 precursor (PLA2G12)<br>Pfam-B_15422 (release 10.0). This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids  . . 
+PF06952 PsiA protein<br>Pfam-B_15432 (release 10.0). This family consists of several Enterobacterial PsiA proteins. The function of PsiA is unknown although it is thought that it may affect the generation of an SOS signal in Escherichia coli  .. 
+PF06953 Arsenical resistance operon trans-acting repressor ArsD<br>Pfam-B_15383 (release 10.0). This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs  .. 
+PF06954 Resistin<br>Pfam-B_15476 (release 10.0). This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes  .. 
+PF06955 Xyloglucan endo-transglycosylase (XET) C-terminus<br>Pfam-B_20045 (release 10.0). This family represents the C-terminus (approximately 60 residues) of plant xyloglucan endo-transglycosylase (XET). Xyloglucan is the predominant hemicellulose in the cell walls of most dicotyledons. With cellulose, it forms a network that strengthens the cell wall. XET catalyses the splitting of xyloglucan chains and the linking of the newly generated reducing end to the non-reducing end of another xyloglucan chain, thereby loosening the cell wall  . Note that all family members contain the Pfam:PF00722 domain.. 
+PF06956 Regulator of RNA terminal phosphate cyclase<br>Pfam-B_17814 (release 10.0). RtcR is a sigma54-dependent enhancer binding protein   that activates transcription of the rtcBA operon. The product of the rtcA gene is an RNA 3'-terminal phosphate cyclase  . This domain is found at the N terminus of the RtcR sequence. RtcR, and other sigma54-dependent activators, contain Pfam:PF00158 in the central region of the protein sequence.. 
+PF06957 Coatomer (COPI) alpha subunit C-terminus<br>Pfam-B_20121 (release 10.0). This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport  . Note that many family members also contain the Pfam:PF04053 domain.. 
+PF06958 S-type Pyocin<br>Pfam-B_20020 (release 10.0). This family represents a conserved region approximately 180 residues long within bacterial S-type pyocins. Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity  .. 
+PF06959 RecQ helicase protein-like 5 (RecQ5)<br>Pfam-B_20083 (release 10.0). This family represents a conserved region approximately 200 residues long within eukaryotic RecQ helicase protein-like 5 (RecQ5). The RecQ helicases have been implicated in DNA repair and recombination, and RecQ5 may have an important role in DNA metabolism  .. 
+PF06961 Protein of unknown function (DUF1294)<br>Pfam-B_3405 (release 10.0). This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.. 
+PF06962 Putative rRNA methylase<br>Pfam-B_3461 (release 10.0). This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.. 
+PF06963 Ferroportin1 (FPN1)<br>Pfam-B_3588 (release 10.0). This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell  . This family may represent a number of transmembrane regions in Ferroportin1.. 
+PF06964 Alpha-L-arabinofuranosidase C-terminus<br>Pfam-B_3625 (release 10.0). This family represents the C-terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase (EC:3.2.1.55). This catalyses the hydrolysis of nonreducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides  .. 
+PF06965 Na+/H+ antiporter 1<br>Pfam-B_1828 (release 10.0). This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH  .. 
+PF06966 Protein of unknown function (DUF1295)<br>Pfam-B_3514 (release 10.0). This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.. 
+PF06967 Mo-dependent nitrogenase C-terminus<br>Pfam-B_6998 (release 10.0). This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria  . Note that many family members are hypothetical proteins.. 
+PF06968 Biotin and Thiamin Synthesis associated domain<br>Pfam-B_5417 (release 10.0). 
+PF06969 HemN C-terminal domain<br>Pfam-B_833 (release 10.0). Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX  , one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparison to other proteins containing a radical SAM domain (Pfam:PF04055) suggest it may be a substrate binding domain.. 
+PF06970 Replication initiator protein A (RepA) N-terminus<br>Pfam-B_1808 (release 10.0). This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids  . Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included  .. 
+PF06971 Put_DNA-bind_C; <br>Putative DNA-binding protein N-terminus. Pfam-B_3389 (release 10.0). This family represents the N-terminus (approximately 50 residues) of a number of putative bacterial DNA-binding proteins.. 
+PF06972 Protein of unknown function (DUF1296)<br>Vella Briffa B, Eberhardt R. Pfam-B_4035 (release 10.0). This family represents a conserved region approximately 60 residues long within a number of plant proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF06973 Domain of unknown function (DUF1297)<br>Pfam-B_3819 (release 10.0). This family represents the C-terminus (approximately 200 residues) of a number of archaeal proteins of unknown function. One member is annotated as being a possible carboligase enzyme.. 
+PF06974 Protein of unknown function (DUF1298)<br>Pfam-B_4362 (release 10.0). This family represents the C-terminus (approximately 170 residues) of a number of hypothetical plant proteins of unknown function.. 
+PF06975 Protein of unknown function (DUF1299)<br>Pfam-B_3488 (release 10.0). This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that many family members contain multiple copies of this region.. 
+PF06977 SdiA-regulated<br>Pfam-B_2520 (release 10.0). This family represents a conserved region approximately within a number of hypothetical bacterial proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators  . Some family members contain the Pfam:PF01436 repeat.. 
+PF06978 Ribonucleases P/MRP protein subunit POP1<br>Pfam-B_7848 (release 10.0). This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5)  . These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.. 
+PF06979 Protein of unknown function (DUF1301)<br>Pfam-B_8295 (release 10.0). This family contains a number of eukaryotic proteins of unknown function that are approximately 160 residues long.. 
+PF06980 Protein of unknown function (DUF1302)<br>Pfam-B_7023 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.. 
+PF06983 3-demethylubiquinone-9 3-methyltransferase<br>Pfam-B_6583 (release 10.0). This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases (EC:2.1.1.64). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.. 
+PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47)<br>Pfam-B_6890 (release 10.0). This family represents the N-terminal region (approximately 8 residues) of the eukaryotic mitochondrial 39-S ribosomal protein L47 (MRP-L47). Mitochondrial ribosomal proteins (MRPs) are the counterparts of the cytoplasmic ribosomal proteins, in that they fulfil similar functions in protein biosynthesis. However, they are distinct in number, features and primary structure  .. 
+PF06985 Heterokaryon incompatibility protein (HET)<br>Pfam-B_8200 (release 10.0). This family represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins that seem to be restricted to ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two different wild-type strains  . Many family members also contain the Pfam:PF00400 repeat and the  Pfam:PF05729 domain.. 
+PF06986 Type-1V conjugative transfer system mating pair stabilisation<br>Pfam-B_8400 (release 10.0). TraN is a large cysteine-rich outer membrane protein involved in the mating-pair stabilisation (adhesin) component of the F-type conjugative plasmid transfer system. TraN is believed to interact with the core type IV secretion system apparatus through the TraV protein    .. 
+PF06988 NifT/FixU protein<br>Pfam-B_5696 (release 10.0). This family consists of several NifT and FixU bacterial proteins. The function of NifT is unknown although it is thought that the protein may be involved in biosynthesis of the FeMo cofactor of nitrogenase although perturbation of nifT expression in K. pneumoniae has only a limited effect on nitrogen fixation  .. 
+PF06989 BAALC N-terminus<br>Pfam-B_5793 (release 10.0). This family represents the N-terminal region of the mammalian BAALC proteins.\.  BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organisms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumours or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms.  Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions  .. 
+PF06990 Galactose-3-O-sulfotransferase <br>Pfam-B_6301 (release 10.0). This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans  .. 
+PF06991 MFAP1_C;<br>Splicing factor, Prp19-binding domain. Pfam-B_8343 (release 10.0). This family represents the C-terminus (approximately 300 residues) of proteins that are involved as binding partners for Prp19 as part of the nuclear pore complex.\.    The family in Drosophila is necessary for pre-mRNA splicing, and the human protein has been found in purifications of the spliceosome. In the past this family was thought, erroneously, to be associated with microfibrillin.. 
+PF06992 Replication protein P<br>Pfam-B_6611 (release 10.0). This family consists of several Bacteriophage lambda replication protein P like proteins. The bacteriophage lambda P protein promoters replication of the phage chromosome by recruiting a key component of the cellular replication machinery to the viral origin. Specifically, P protein delivers one or more molecules of Escherichia coli DnaB helicase to a nucleoprotein structure formed by the lambda O initiator at the lambda replication origin  . . 
+PF06993 Protein of unknown function (DUF1304)<br>Pfam-B_7246 (release 10.0). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.. 
+PF06994 Involucrin<br>Pfam-B_8443 (release 10.0). This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialised protective barrier) of stratified squamous epithelia  . Members of this family seem to be restricted to mammals.. 
+PF06995 Phage P2 GpU<br>Pfam-B_7670 (release 10.0). This family consists of several bacterial and phage proteins of around 130 residues in length which seem to be related to the bacteriophage P2 GpU protein (Swiss:O64315) which is thought to be involved in tail assembly  .. 
+PF06996 Protein of unknown function (DUF1305)<br>Pfam-B_9388 (release 10.0). This family consists of several hypothetical bacterial proteins of around 300 residues in length. The function of this family is unknown although one member (Swiss:Q93IT4) from Salmonella enterica is thought to be involved in virulence  .. 
+PF06998 Protein of unknown function (DUF1307)<br>Pfam-B_10058 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. Some family members are described as putative lipoproteins but the function of the family is unknown.. 
+PF06999 Sucrase/ferredoxin-like<br>Pfam-B_8856 (release 10.0). This family contains a number of bacterial and eukaryotic proteins approximately 400 residues long that resemble ferredoxin and appear to have sucrolytic activity  .. 
+PF07000 Protein of unknown function (DUF1308)<br>Pfam-B_13288 (release 10.0). This family consists of several hypothetical eukaryotic sequences of around 400 residues in length. The function of this family is unknown.. 
+PF07001 BAT2 N-terminus<br>Pfam-B_9101 (release 10.0). This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin  .. 
+PF07002 Copine<br>Pfam-B_9705 (release 10.0). This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth  .. 
+PF07004 DUF1309;<br>Sperm-tail PG-rich repeat. Pfam-B_8734 (release 10.0). This family represents a short conserved region carrying a PGP motif that is repeated in eukaryotic proteins of sperm-tails. Shippo orthologues from some species may include up to 40 Pro-Gly-Pro repeats.. 
+PF07005 Hop; PF07005; <br>Protein of unknown function, DUF1537. Pfam-B_8609 (release 10.0). This conserved region is found in proteins of unknown function in a range of Proteobacteria as well as the  Gram-positive Oceanobacillus iheyensis.. 
+PF07006 Protein of unknown function (DUF1310)<br>Pfam-B_10153 (release 10.0). This family consists of several hypothetical proteins of around 125 residues in length. Members of this family seem to be specific to Listeria and Streptococcus species. The function of this family is unknown.. 
+PF07007 Protein of unknown function (DUF1311)<br>Pfam-B_10506 (release 10.0). This family consists of several bacterial proteins of around 120 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.. 
+PF07009 Protein of unknown function (DUF1312)<br>Pfam-B_10829 (release 10.0). This family consists of several bacterial proteins of around 120 residues in length. The function of this family is unknown.. 
+PF07010 Endomucin<br>Pfam-B_10834 (release 10.0). This family consists of several mammalian endomucin proteins. Endomucin is an early endothelial-specific antigen that is also expressed on putative hematopoietic progenitor cells. . 
+PF07011 Protein of unknown function (DUF1313)<br>Pfam-B_10989 (release 10.0). This family consists of several hypothetical plant proteins of around 100 residues in length. The function of this family is unknown.. 
+PF07012 Curlin associated repeat<br>Pfam-B_10299 (release 10.0). This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilisation of CsgA and CsgB  . . 
+PF07013 Protein of unknown function (DUF1314)<br>Pfam-B_10999 (release 10.0). This family consists of several Alphaherpesvirus proteins of around 200 residues in length. The function of this family is unknown.. 
+PF07014 Hs1pro-1; <br>Hs1pro-1 protein C-terminus. Moxon SJ, Vella Briffa B. Pfam-B_11205 (release 10.0). This family represents the C-terminus (approximately 270 residues) of a number of plant Hs1pro-1 proteins, which are believed to confer nematode resistance  .. 
+PF07015 VirC1 protein<br>Pfam-B_11309 (release 10.0). This family consists of several bacterial VirC1 proteins. In Agrobacterium tumefaciens, a cis-active 24-base-pair sequence adjacent to the right border of the T-DNA, called overdrive, stimulates tumour formation by increasing the level of T-DNA processing. It is thought that the virC operon which enhances T-DNA processing probably does so because the VirC1 protein interacts with overdrive. It has now been shown that the virC1 gene product binds to overdrive but not to the right border of T-DNA  . . 
+PF07016 Cysteine-rich acidic integral membrane protein precursor<br>Pfam-B_11042 (release 10.0). This family consists of several 24 residue repeats from the Trypanosoma brucei cysteine-rich, acidic integral membrane protein precursor (CRAM). CRAM is concentrated in the flagellar pocket, an invagination of the cell surface of the trypanosome where endocytosis has been documented  .. 
+PF07017 Antimicrobial peptide resistance and lipid A acylation protein PagP<br>Pfam-B_11014 (release 10.0). This family consists of several bacterial antimicrobial peptide resistance and lipid A acylation (PagP) proteins. The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response. . 
+PF07019 Rab5-interacting protein (Rab5ip)<br>Pfam-B_11031 (release 10.0). This family consists of several Rab5-interacting protein (RIP5 or Rab5ip ) sequences. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5  .. 
+PF07020 Orthopoxvirus C10L protein<br>Pfam-B_12732 (release 10.0). This family consists of several Orthopoxvirus C10L proteins. C10L viral protein can play an important role in vaccinia virus evasion of the host immune system. It may consist in the blockade of IL-1 receptors by the C10L protein, a homologue of the IL-1 Ra  . . 
+PF07021 Methionine biosynthesis protein MetW<br>Pfam-B_11086 (release 10.0). This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalysed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganisms the reaction is catalysed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells  . . 
+PF07022 Bacteriophage CI repressor helix-turn-helix domain<br>Pfam-B_11145 (release 10.0). This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic  .. 
+PF07023 Protein of unknown function (DUF1315)<br>Pfam-B_11170 (release 10.0). This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.. 
+PF07024 ImpE protein<br>Pfam-B_11208 (release 10.0). This family consists of several bacterial proteins including ImpE (Swiss:Q93EC9) from Rhizobium leguminosarum. It has been suggested that the imp locus is involved in the secretion to the environment of proteins, including periplasmic RbsB protein, that cause blocking of infection specifically in pea plants  . The exact function of this family is unknown.. 
+PF07026 Protein of unknown function (DUF1317)<br>Pfam-B_12646 (release 10.0). This family consists of several hypothetical bacterial and phage proteins of around 60 residues in length. The function of this family is unknown.. 
+PF07027 Protein of unknown function (DUF1318)<br>Pfam-B_11321 (release 10.0). This family consists of several bacterial proteins of around 100 residues in length and is often known as YdbL. The function of this family is unknown.. 
+PF07028 Protein of unknown function (DUF1319)<br>Pfam-B_10434 (release 10.0). This family contains a number of viral proteins of unknown function approximately 200 residues long. Family members seem to be restricted to badnaviruses.. 
+PF07029 CryBP1 protein<br>Pfam-B_11415 (release 10.0). This family consists of several CryBP1 like proteins from Bacillus thuringiensis and Paenibacillus popilliae. Members of this family are thought to be involved in the overall toxicity of the bacteria to their hosts [1,2].. 
+PF07030 Protein of unknown function (DUF1320)<br>Pfam-B_13638 (release 10.0). This family consists of both hypothetical bacterial and phage proteins of around 145 residues in length. The function of this family is unknown.. 
+PF07032 Protein of unknown function (DUF1322)<br>Pfam-B_13233 (release 10.0). This family consists of several hypothetical 9.4 kDa Borrelia burgdorferi (Lyme disease spirochete) proteins of around 78 residues in length. The function of this family is unknown.. 
+PF07033 Orthopoxvirus B11R protein<br>Pfam-B_13245 (release 10.0). This family consists of several Orthopoxvirus B11R proteins of around 70 residues in length. The function of this family is unknown.. 
+PF07034 Origin recognition complex (ORC) subunit 3 N-terminus<br>Pfam-B_10452 (release 10.0). This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication  .. 
+PF07035 Colon cancer-associated protein Mic1-like<br>Pfam-B_10041 (release 10.0). This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.. 
+PF07037 Putative transcription regulator (DUF1323)<br>Pfam-B_12705 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 120 residues in length. This family appears to have an HTH domain and is therefore likely to act as a transcriptional regulator.. 
+PF07038 Protein of unknown function (DUF1324)<br>Pfam-B_12735 (release 10.0). This family consists of several Circovirus proteins of around 60 residues in length. The function of this family is unknown.. 
+PF07039 SGF29 tudor-like domain<br>Pfam-B_13304 (release 10.0). This domain is found in the yeast protein SAGA-associated factor 29. This domain is related to members of the Tudor domain superfamily such as Pfam:PF05641. The SAGA complex is involved in RNA polymerase II-dependent transcriptional regulation. The membership of the tudor domain superfamily suggests this domain may bind to RNA.. 
+PF07040 Protein of unknown function (DUF1326)<br>Pfam-B_11597 (release 10.0). This family consists of several hypothetical bacterial proteins which seem to be found exclusively in Rhizobium and Ralstonia species. Members of this family are typically around 210 residues in length and contain 5 highly conserved cysteine residues at their N-terminus. The function of this family is unknown.. 
+PF07041 Protein of unknown function (DUF1327)<br>Pfam-B_11630 (release 10.0). This family consists of several hypothetical bacterial proteins of around 115 residues in length which seem to be specific to Escherichia coli. The function of this family is unknown.. 
+PF07042 TrfA protein<br>Pfam-B_12321 (release 10.0). This family consists of several bacterial TrfA proteins. The trfA operon of broad-host-range IncP plasmids is essential to activate the origin of vegetative replication in diverse species. The trfA operon encodes two ORFs. The first ORF is highly conserved and encodes a putative single-stranded DNA binding protein (Ssb). The second, trfA, contains two translational starts as in the IncP alpha plasmids, generating related polypeptides of 406 (TrfA1) and 282 (TrfA2) amino acids. TrfA2 is very similar to the IncP alpha product, whereas the N-terminal region of TrfA1 shows very little similarity to the equivalent region of IncP alpha TrfA1. This region has been implicated in the ability of IncP alpha plasmids to replicate efficiently in Pseudomonas aeruginosa  .. 
+PF07043 Protein of unknown function (DUF1328)<br>Pfam-B_12535 (release 10.0). This family consists of several hypothetical bacterial proteins of around 50 residues in length. The function of this family is unknown.. 
+PF07044 Protein of unknown function (DUF1329)<br>Pfam-B_12608 (release 10.0). This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica.. 
+PF07045 Protein of unknown function (DUF1330)<br>Pfam-B_12466 (release 10.0). This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.. 
+PF07046 Cytoplasmic repetitive antigen (CRA) like repeat<br>Pfam-B_12798 (release 10.0). This family consists of several repeats of around 42 residues in length. These repeated sequences are found in multiple copies in Trypanosoma cruzi antigens, Swiss:Q26907 contains 23 copies of this repeat.. 
+PF07047 Optic atrophy 3 protein (OPA3)<br>Pfam-B_12863 (release 10.0). This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity  . . 
+PF07048 Protein of unknown function (DUF1331)<br>Pfam-B_12865 (release 10.0). This family consists of several Circovirus proteins of around 35 residues in length. Members of this family are described as ORF-10 proteins and their function is unknown.. 
+PF07051 Ovarian carcinoma immunoreactive antigen (OCIA)<br>Pfam-B_13720 (release 10.0). This family consists of several ovarian carcinoma immunoreactive antigen  (OCIA) and related eukaryotic sequences. The function of this family is unknown [1,2].. 
+PF07052 Hepatocellular carcinoma-associated antigen 59<br>Pfam-B_10544 (release 10.0). This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 and similar proteins. Family members are found in a variety of eukaryotes, mainly as hypothetical proteins.. 
+PF07054 Pericardin like repeat<br>Pfam-B_13724 (release 10.0). This family consists of several repeated sequences of around 34 residues in length. This repeat is found in multiple copies in the Drosophila pericardin and other extracellular matrix proteins.. 
+PF07055 scADH;<br>Enoyl reductase FAD binding domain. Vella Briffa B, Coggill P. Pfam-B_10602 (release 10.0). This family carries the region of the enzyme trans-2-enoyl-CoA reductase, at the very C-terminus, that binds to FAD. The activity was characterised in Euglena where an unusual fatty acid synthesis path-way in mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The conserved region is seen as the motif FGFxxxxxDY  .. 
+PF07056 Protein of unknown function (DUF1335)<br>Pfam-B_10636 (release 10.0). This family represents a conserved region approximately 130 residues long within a number of proteins of unknown function that seem to be specific to the white spot syndrome virus (WSSV).. 
+PF07057 DNA helicase TraI<br>Pfam-B_10638 (release 10.0). This family represents a conserved region approximately 130 residues long within the bacterial DNA helicase TraI (EC:3.6.1.-). TraI is a bifunctional protein that catalyses the unwinding of duplex DNA as well as acts as a sequence-specific DNA trans-esterase, providing the site- and strand-specific nick required to initiate DNA transfer  .. 
+PF07058 Myosin II heavy chain-like<br>Pfam-B_10658 (release 10.0). This family represents a conserved region within a number of myosin II heavy chain-like proteins that seem to be specific to Arabidopsis thaliana.. 
+PF07059 Protein of unknown function (DUF1336)<br>Pfam-B_10173 (release 10.0). This family represents the C-terminus (approximately 250 residues) of a number of hypothetical plant proteins of unknown function.. 
+PF07061 DUF1337; <br>Swi5 is involved in meiotic DNA repair synthesis and meiotic joint molecule formation    .  It is known to interact with Swi2, Rhp51 and Swi6  .. 
+PF07062 Clc-like<br>Pfam-B_11218 (release 10.0). This family contains a number of Clc-like proteins that are approximately 250 residues long.. 
+PF07063 Domain of unknown function (DUF1338)<br>Pfam-B_10864 (release 10.0). This domain is found in a variety of bacterial and fungal hypothetical proteins of unknown function. The structure of this domain has been solved by structural genomics. The structure implies a zinc-binding function, so it is a putative metal hydrolase (information derived from TOPSAN for PDB:3iuz).. 
+PF07064 DUF1339; <br>Vella Briffa B, Wood V. Pfam-B_11581 (release 10.0). RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network.  It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor  .. 
+PF07065 D123<br>Pfam-B_10915 (release 10.0). This family contains a number of eukaryotic D123 proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate  . D123 proteins are regulators of eIF2, the central regulator of  translational initiation  .. 
+PF07066 Phage_Lacto_M3;<br>Lactococcus phage M3 protein. Pfam-B_13997 (release 10.0). This family consists of several Lactococcus phage middle-3 (M3) proteins of around 160 residues in length. The function of this family is unknown.. 
+PF07067 Protein of unknown function (DUF1340)<br>Pfam-B_14083 (release 10.0). This family consists of several hypothetical Streptococcus thermophilus bacteriophage proteins of around 235 residues in length. The function of this family is unknown.. 
+PF07068 Major capsid protein Gp23<br>Pfam-B_12245 (release 10.0). This family contains a number of major capsid Gp23 proteins approximately 500 residues long, from T4-like bacteriophages.. 
+PF07069 Porcine reproductive and respiratory syndrome virus 2b <br>Pfam-B_13261 (release 10.0). This family consists of several Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2b proteins. The function of this family is unknown however it is known that large amounts of 2b protein are present in the virion and it is thought that this protein may be an integral component of the virion  .. 
+PF07070 SpoOM protein<br>Pfam-B_13263 (release 10.0). This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH  .. 
+PF07071 Protein of unknown function (DUF1341)<br>Pfam-B_14024 (release 10.0). This family consists of several hypothetical bacterial proteins of around 220 residues in length. The function of this family is unknown.. 
+PF07072 Protein of unknown function (DUF1342)<br>Pfam-B_14075 (release 10.0). This family consists of several hypothetical bacterial proteins of around 250 residues in length. Members of this family are often known as YacF after the Escherichia coli protein Swiss:P36680. The function of this family is unknown.. 
+PF07073 Modulator of Rho-dependent transcription termination (ROF)<br>Pfam-B_13280 (release 10.0). This family consists of several bacterial modulator of Rho-dependent transcription termination (ROF) proteins. ROF binds transcription termination factor Rho and inhibits Rho-dependent termination in vivo  . . 
+PF07074 Translocon-associated protein, gamma subunit (TRAP-gamma)<br>Pfam-B_13437 (release 10.0). This family consists of several eukaryotic translocon-associated protein, gamma subunit (TRAP-gamma) sequences. The translocation site (translocon), at which nascent polypeptides pass through the endoplasmic reticulum membrane, contains a component previously called 'signal sequence receptor' that is now renamed as 'translocon-associated protein' (TRAP). The TRAP complex is comprised of four membrane proteins alpha, beta, gamma and delta which are present in a stoichiometric relation, and are genuine neighbours in intact microsomes.  The gamma subunit is predicted to span the membrane four times  . . 
+PF07075 Protein of unknown function (DUF1343)<br>Pfam-B_13635 (release 10.0). This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.. 
+PF07076 Protein of unknown function (DUF1344)<br>Pfam-B_13761 (release 10.0). This family consists of several short, hypothetical bacterial proteins of around 80 residues in length. Members of this family are found in Rhizobium, Agrobacterium and Brucella species. The function of this family is unknown.. 
+PF07077 Protein of unknown function (DUF1345)<br>Pfam-B_13768 (release 10.0). This family consists of several hypothetical bacterial proteins of around 230 residues in length. The function of this family is unknown.. 
+PF07078 DUF1346; <br>Forty-two-three protein. Pfam-B_13991 (release 10.0). This family consists of several mammalian proteins of around 320 residues in length called 40-2-3 proteins. The function of this family is unknown.. 
+PF07079 Protein of unknown function (DUF1347)<br>Pfam-B_14317 (release 10.0). This family consists of several hypothetical bacterial proteins of around 610 residues in length. Members of this family are highly conserved and seem to be specific to Chlamydia species. The function of this family is unknown.. 
+PF07080 Protein of unknown function (DUF1348)<br>Pfam-B_14137 (release 10.0). This family consists of several highly conserved hypothetical proteins of around 150 residues in length. The function of this family is unknown.. 
+PF07081 Protein of unknown function (DUF1349)<br>Pfam-B_14150 (release 10.0). This family consists of several hypothetical bacterial proteins but contains one sequence (Swiss:P40893) from Saccharomyces cerevisiae. Members of this family are typically around 200 residues in length. The function of this family is unknown.. 
+PF07082 Protein of unknown function (DUF1350)<br>Pfam-B_14167 (release 10.0). This family consists of several hypothetical proteins from both cyanobacteria and plants. Members of this family are typically around 250 residues in length. The function of this family is unknown but the species distribution indicates that the family may be involved in photosynthesis.. 
+PF07083 Protein of unknown function (DUF1351)<br>Pfam-B_14178 (release 10.0). This family consists of several bacterial and phage proteins of around 230 residues in length. The function of this family is unknown.. 
+PF07084 Thyroid hormone-inducible hepatic protein Spot 14<br>Pfam-B_14186 (release 10.0). This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesise triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression  . Spot 14 protein is thought to be required for induction of hepatic lipogenesis  .. 
+PF07085 DRTGG domain<br>
+PF07086 Protein of unknown function (DUF1352)<br>Pfam-B_14369 (release 10.0). This family consists of several hypothetical eukaryotic proteins of around 190 residues in length. The function of this family is unknown.. 
+PF07087 Protein of unknown function (DUF1353)<br>Pfam-B_14433 (release 10.0). This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.. 
+PF07088 GvpD gas vesicle protein<br>Pfam-B_14302 (release 10.0). This family consists of several archaeal GvpD gas vesicle proteins. GvpD is thought to be involved in the regulation of gas vesicle formation [1,2].. 
+PF07090 Protein of unknown function (DUF1355)<br>Pfam-B_14563 (release 10.0). This family consists of several hypothetical bacterial proteins of around 250 residues in length. The function of this family is unknown. THe structure of this domain was solved by the Midwest Center for Structural Genomics (MCSG). The structure has been classified as part of the Class-I Glutamine amidotransferase superfamily.. 
+PF07091 Ribosomal RNA methyltransferase (FmrO)<br>Pfam-B_14605 (release 10.0). This family consists of several bacterial ribosomal RNA methyltransferase (aminoglycoside-resistance methyltransferase) proteins [1,2].. 
+PF07092 Protein of unknown function (DUF1356)<br>Pfam-B_14617 (release 10.0). This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.. 
+PF07093 SGT1 protein<br>Pfam-B_14698 (release 10.0). This family consists of several eukaryotic SGT1 proteins. Human SGT1 or hSGT1 is known to suppress GCR2 and is highly expressed in the muscle and heart. The function of this family is unknown although it has been speculated that SGT1 may be functionally analogous to the Gcr2p protein of Saccharomyces cerevisiae which is known to be a regulatory factor of glycolytic gene expression  .. 
+PF07094 Protein of unknown function (DUF1357)<br>Pfam-B_14833 (release 10.0). This family consists of several hypothetical bacterial proteins of around 225 residues in length. Members of this family appear to be specific Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.. 
+PF07095 Intracellular growth attenuator protein IgaA<br>Pfam-B_14923 (release 10.0). This family consists of several bacterial intracellular growth attenuator  (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria  . . 
+PF07096 Protein of unknown function (DUF1358)<br>Pfam-B_14731 (release 10.0). This family consists of several hypothetical eukaryotic proteins of around 125 residues in length. The function of this family is unknown.. 
+PF07097 Protein of unknown function (DUF1359)<br>Pfam-B_14784 (release 10.0). This family consists of several hypothetical bacterial and phage proteins of around 100 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this species. The function of this family is unknown.. 
+PF07098 Protein of unknown function (DUF1360)<br>Pfam-B_14863 (release 10.0). This family consists of several bacterial proteins of around 115 residues in length. Members of this family are found in Bacillus species and Streptomyces coelicolor, the function of the family is unknown.. 
+PF07099 Protein of unknown function (DUF1361)<br>Pfam-B_14870 (release 10.0). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.. 
+PF07100 DUF1362;<br>Anabaena sensory rhodopsin transducer. Pfam-B_14972 (release 10.0). The family of bacterial Anabaena sensory rhodopsin transducers are likely to bind sugars or related metabolites. The entire protein is comprised of a single globular domain with an eight-stranded beta-sandwich fold. There are a few characteristics which define this beta-sandwich fold as being distinct from other so-named folds, and these are: 1) a well conserved tryptophan, usually following a polar residue, present at the start of the first strand; this tryptophan appears to be central to a hydrophobic interaction required to hold the two beta-sheets of the sandwich together, and 2) a nearly absolutely conserved asparagine located at the end of the second beta-strand, that hydrogen bonds with the backbone carbonyls of the residues 2 and 4 positions downstream from it, thereby stabilising the characteristic tight turn between strands 2 and 3 of the structure.. 
+PF07101 Protein of unknown function (DUF1363)<br>Pfam-B_14992 (release 10.0). This family consists of several Trypanosoma brucei putative variant specific antigen proteins of around 80 residues in length.. 
+PF07102 Protein of unknown function (DUF1364)<br>Pfam-B_14821 (release 10.0). This family consists of several bacterial and phage proteins of around 95 residues in length. The function of this family is unknown. . 
+PF07103 Protein of unknown function (DUF1365)<br>Pfam-B_14846 (release 10.0). This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.. 
+PF07104 Protein of unknown function (DUF1366)<br>Pfam-B_14849 (release 10.0). This family consists of several hypothetical Streptococcus thermophilus bacteriophage proteins of around 130 residues in length. One of the sequences in this family, from phage Sfi11 (Swiss:O80186) is known as Gp149. The function of this family is unknown. . 
+PF07105 Protein of unknown function (DUF1367)<br>Pfam-B_14892 (release 10.0). This family consists of several highly conserved, hypothetical phage proteins of around 200 residues in length. The function of this family is unknown. Some proteins are annotated as IrsA (intracellular response to stress).. 
+PF07106 Tat binding protein 1(TBP-1)-interacting protein (TBPIP)<br>Pfam-B_14830 (release 10.0). This family consists of several eukaryotic TBP-1 interacting protein (TBPIP) sequences. TBP-1 has been demonstrated to interact with the human immunodeficiency virus type 1 (HIV-1) viral protein Tat, then modulate the essential replication process of HIV. In addition, TBP-1 has been shown to be a component of the 26S proteasome, a basic multiprotein complex that degrades ubiquitinated proteins in an ATP-dependent fashion. Human TBPIP interacts with human TBP-1 then modulates the inhibitory action of human TBP-1 on HIV-Tat-mediated transactivation  .. 
+PF07107 Wound-induced protein WI12<br>Pfam-B_15477 (release 10.0). This family consists of several plant wound-induced protein sequences related to WI12 from Mesembryanthemum crystallinum (Swiss:Q9XES3). Wounding, methyl jasmonate, and pathogen infection is known to induce local WI12 expression. WI12 expression is also thought to be developmentally controlled in the placenta and developing seeds. WI12 preferentially accumulates in the cell wall and it has been suggested that it plays a role in the reinforcement of cell wall composition after wounding and during plant development  . This family seems partly related to the NTF2-like superfamily.. 
+PF07108 PipA protein<br>Pfam-B_15507 (release 10.0). This family consists of several Salmonella PipA (pathogenicity island-encoded protein A) and related phage sequences. PipA is thought to contribute to enteric but not to systemic salmonellosis  . The family carries a highly conserved HEXXH sequence motif along with several highly conserved glutamic acid residues which might be indicative of the family being a metallo-peptidase.. 
+PF07109 Magnesium-protoporphyrin IX methyltransferase C-terminus<br>Pfam-B_12015 (release 10.0). This family represents the C-terminus (approximately 100 residues) of bacterial and eukaryotic Magnesium-protoporphyrin IX methyltransferase (EC:2.1.1.11). This converts magnesium-protoporphyrin IX to magnesium-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor  .. 
+PF07110 EthD domain<br>Pfam-B_15539 (release 10.0). This family consists of several bacterial sequences which are related to the EthD protein of Rhodococcus ruber (Swiss:Q93EX2). In Rhodococcus ruber, EthD is thought to be involved in the degradation of ethyl tert-butyl ether (ETBE). EthD synthesis is induced by ETBE but it's exact function is unknown, it is however thought to be essential to the ETBE degradation system.. 
+PF07111 Alpha helical coiled-coil rod protein (HCR)<br>Pfam-B_15548 (release 10.0). This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation  .. 
+PF07112 Protein of unknown function (DUF1368)<br>Pfam-B_14994 (release 10.0). This family consists of several proteins with seem to be specific to red algae plasmids. Members of this family are typically around 415 residues in length. The function of this family is unknown.. 
+PF07114 Protein of unknown function (DUF1370)<br>Pfam-B_15274 (release 10.0). This family consists of several hypothetical eukaryotic proteins of around 200 residues in length. Members of this family seem to be specific to mammals and their function is unknown.. 
+PF07115 Protein of unknown function (DUF1371)<br>Pfam-B_15275 (release 10.0). This family consists of several hypothetical bacterial proteins of around 110 residues in length. The function of this family is unknown but members seem to be specific to Borrelia burgdorferi (Lyme disease spirochete).. 
+PF07116 Protein of unknown function (DUF1372)<br>Pfam-B_15278 (release 10.0). This family consists of several Streptococcus bacteriophage sequences and related proteins from Streptococcus species. Members of this family are typically around 100 residues in length and their function is unknown.. 
+PF07117 Protein of unknown function (DUF1373)<br>Pfam-B_15084 (release 10.0). This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.. 
+PF07118 Protein of unknown function (DUF1374)<br>Pfam-B_15191 (release 10.0). This family consists of several hypothetical Sulfolobus virus proteins of around 100 residues in length. The function of this family is unknown.. 
+PF07119 Protein of unknown function (DUF1375)<br>Pfam-B_15247 (release 10.0). This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the Class Gammaproteobacteria. The function of this family is unknown.. 
+PF07120 Protein of unknown function (DUF1376)<br>Pfam-B_15380 (release 10.0). This family consists of several hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.. 
+PF07122 Variable length PCR target protein (VLPT)<br>Pfam-B_15500 (release 10.0). This family consists of a number of 29 residue repeats which seem to be specific to the Ehrlichia chaffeensis variable length PCR target (VLPT) protein. Ehrlichia chaffeensis is a tick-transmitted rickettsial agent and is responsible for human monocytic ehrlichiosis (HME). The function of this family is unknown  . . 
+PF07123 PsbW_2; <br>Photosystem II reaction centre W protein (PsbW). Pfam-B_15117 (release 10.0). This family consists of several plant specific photosystem II reaction centre W (PsbW) proteins. PsbW is a nuclear-encoded protein located in the thylakoid membrane of the chloroplast. PsbW is a core component of photosystem II but not photosystem I  . This family does not appear to be related to Pfam:PF03912.. 
+PF07124 Phytoreovirus outer capsid protein P8<br>Pfam-B_15606 (release 10.0). This family consists of several Phytoreovirus outer capsid protein P8 sequences  .. 
+PF07125 Protein of unknown function (DUF1378)<br>Pfam-B_15650 (release 10.0). This family consists of hypothetical bacterial and phage proteins of around 59 residues in length. Bacterial members of this family seem to be specific to Enterobacteria. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF07126 Protein of unknown function (DUF1379)<br>Pfam-B_15837 (release 10.0). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.. 
+PF07127 Late nodulin protein<br>Pfam-B_15657 (release 10.0). This family consists of several plant specific late nodulin sequences which are homologous to the Pisum sativum (Garden pea) ENOD3 protein.  ENOD3 is expressed in the late stages of root nodule formation and contains two pairs of cysteine residues towards the C-terminus which may be involved in metal-binding  .. 
+PF07128 Protein of unknown function (DUF1380)<br>Pfam-B_15699 (release 10.0). This family consists of several hypothetical bacterial proteins of around 140 residues in length. Members of this family seem to be specific to Enterobacteria. The function of this family is unknown.. 
+PF07129 Protein of unknown function (DUF1381)<br>Pfam-B_15743 (release 10.0). This family consists of several hypothetical Staphylococcus aureus and Staphylococcus aureus bacteriophage proteins of around 65 residues in length. The function of this family is unknown.. 
+PF07130 YebG protein<br>Pfam-B_15760 (release 10.0). This family consists of several bacterial YebG proteins of around 75 residues in length. The exact function of this protein is unknown but it is thought to be involved in the SOS response. The induction of the yebG gene occurs as cell enter into the stationary growth phase and is dependent on  is dependent on cyclic AMP and H-NS  . . 
+PF07131 Protein of unknown function (DUF1382)<br>Moxon SJ, Eberhardt R. Pfam-B_15770 (release 10.0). This family consists of several hypothetical Escherichia coli and bacteriophage lambda-like proteins of around 60 residues in length.  The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF07133 Merozoite surface protein (SPAM)<br>Pfam-B_15860 (release 10.0). This family consists of several Plasmodium falciparum SPAM (secreted polymorphic antigen associated with merozoites) proteins. Variation among SPAM alleles is the result of deletions and amino acid substitutions in non-repetitive sequences within and flanking the alanine heptad-repeat domain. Heptad repeats in which the a and d position contain hydrophobic residues generate amphipathic alpha-helices which give rise to helical bundles or coiled-coil structures in proteins. SPAM is an example of a P. falciparum antigen in which a repetitive sequence has features characteristic of a well-defined structural element [1,2]. . 
+PF07134 Protein of unknown function (DUF1383)<br>Pfam-B_15868 (release 10.0). This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 375 residues in length. The function of this family is unknown.. 
+PF07136 Protein of unknown function (DUF1385)<br>Pfam-B_12671 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function approximately 300 residues in length. Some family members are predicted to be metal-dependent.. 
+PF07137 Violaxanthin de-epoxidase (VDE)<br>Pfam-B_12679 (release 10.0). This family represents a conserved region approximately 150 residues long within plant violaxanthin de-epoxidase (VDE). In higher plants, violaxanthin de-epoxidase forms part of a conserved system that dissipates excess energy as heat in the light-harvesting complexes of photosystem II (PSII), thus protecting them from photo-inhibitory damage  .. 
+PF07138 Protein of unknown function (DUF1386)<br>Pfam-B_16196 (release 10.0). This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 350 residues in length. The function of this family is unknown.. 
+PF07139 Protein of unknown function (DUF1387)<br>Pfam-B_10471 (release 10.0). This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.. 
+PF07140 Interferon gamma receptor (IFNGR1)<br>Pfam-B_15930 (release 10.0). This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta).  The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection  . The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac Pfam:PF01108.. 
+PF07141 Putative bacteriophage terminase small subunit<br>Pfam-B_15957 (release 10.0). This family consists of several putative Lactococcus bacteriophage terminase small subunit proteins. The exact function of this family is unknown.. 
+PF07142 Repeat of unknown function (DUF1388)<br>Pfam-B_16000 (release 10.0). This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo  .. 
+PF07143 Hydroxyneurosporene synthase (CrtC)<br>Pfam-B_16004 (release 10.0). This family consists of several purple photosynthetic bacterial hydroxyneurosporene synthase (CrtC) proteins. The enzyme catalyses the conversion of various acyclic carotenes including 1-hydroxy derivatives. This broad substrate specificity reflects the participation of CrtC in 1'-HO-spheroidene and in spirilloxanthin biosynthesis  .\.      This family also contains the members of the old Pfam family DUF2006.  Structural characterisation of DUF2006 family member Swiss:Q82US3 has revealed a lipocalin-like fold with domain duplication.. 
+PF07145 Ataxin-2; Ataxin-2_C;<br>Ataxin-2 C-terminal region. The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for Pfam:PF00658. It has been found in a wide range of eukaryotic proteins  . Strikingly, this motif appears to occur solely outside of globular domains  .. 
+PF07146 Protein of unknown function (DUF1389)<br>Pfam-B_16027 (release 10.0). This family consists of several hypothetical bacterial proteins which seem to be specific to Chlamydia pneumoniae. Members of this family are typically around 400 residues in length. The function of this family is unknown.. 
+PF07147 Mitochondrial 28S ribosomal protein S30 (PDCD9)<br>Pfam-B_16045 (release 10.0). This family consists of several eukaryotic mitochondrial 28S ribosomal protein S30 (or programmed cell death protein 9 PDCD9) sequences. The exact function of this family is unknown although it is known to be a component of the mitochondrial ribosome and a component in cellular apoptotic signaling pathways  .. 
+PF07148 Maltose operon periplasmic protein precursor (MalM)<br>Pfam-B_16111 (release 10.0). This family consists of several maltose operon periplasmic protein precursor (MalM) sequences. The function of this family is unknown  .. 
+PF07149 Pes-10<br>Pfam-B_16134 (release 10.0). This family consists of several Caenorhabditis elegans pes-10 and related proteins. Members of this family are typically around 400 residues in length. The function of this family is unknown.. 
+PF07150 Protein of unknown function (DUF1390)<br>Pfam-B_16182 (release 10.0). This family consists of several Paramecium bursaria chlorella virus 1 (PBCV-1) proteins of around 250 residues in length. The function of this family is unknown.. 
+PF07151 Protein of unknown function (DUF1391)<br>Pfam-B_16216 (release 10.0). This family consists of several Enterobacterial proteins of around 50 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi where they are often known as YdfA. The function of this family is unknown.. 
+PF07152 YaeQ protein<br>Pfam-B_16245 (release 10.0). This family consists of several hypothetical bacterial proteins of around 180 residues in length which are often known as YaeQ. YaeQ is homologous to RfaH, a specialised transcription elongation protein. YaeQ is known to compensate for loss of RfaH function  .. 
+PF07153 Marek's disease-like virus SORF3 protein<br>Pfam-B_16263 (release 10.0). This family consists of several SORF3 proteins from the Marek's disease-like viruses. Members of this family are around 350 residues in length. The function of this family is unknown.. 
+PF07154 Protein of unknown function (DUF1392)<br>Pfam-B_16270 (release 10.0). This family consists of several hypothetical cyanobacterial proteins of around 150 residues in length which seem to be specific to Anabaena species. The function of this family is unknown.. 
+PF07155 DUF1393;<br>ECF-type riboflavin transporter, S component. Moxon SJ, Eberhardt R. Pfam-B_16301 (release 10.0). This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells [1,2].. 
+PF07156 Prenylcysteine lyase<br>Pfam-B_12448 (release 10.0). This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction  . It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps  .. 
+PF07157 DNA circularisation protein N-terminus<br>Pfam-B_12343 (release 10.0). This family represents the N-terminus (approximately 100 residues) of a number of phage DNA circularisation proteins.. 
+PF07158 Dicarboxylate carrier protein MatC N-terminus<br>Pfam-B_16346 (release 10.0). This family represents the N-terminal region of the bacterial dicarboxylate carrier protein MatC. The MatC protein is an integral membrane protein that could function as a malonate carrier  .. 
+PF07159 Protein of unknown function (DUF1394)<br>Pfam-B_16260 (release 10.0). This family consists of several hypothetical eukaryotic proteins of around 320 residues in length. The function of this family is unknown.. 
+PF07160 Protein of unknown function (DUF1395)<br>Pfam-B_16376 (release 10.0). This family consists of several hypothetical eukaryotic proteins of around 250 residues in length. The function of this family is unknown.. 
+PF07161 Protein of unknown function (DUF1396)<br>Pfam-B_16343 (release 10.0). This family consists of several putative lipoproteins from Mycobacterium species. The function of this family is unknown.. 
+PF07162 B9;<br>Ciliary basal body-associated, B9 protein. Vella Briffa B, Coggill P. Pfam-B_12595 (release 10.0). The B9-C2 domain is found in proteins associated with the ciliary basal body. B9 domains were identified as a specific family of C2 domains  .  There are three sub-families represented by this family, notably, Mks1-Xbx7, Stumpy-Tza1 and Tza2 groups of proteins. Mutations in human Mks1 result in the developmental disorder Mechler-Gruber syndrome  ; mutations in mouse Stumpy lead to perinatal hydrocephalus and severe polycystic kidney disease  . All the three distinct types of B9-C2 proteins cooperatively localise to the basal body or centrosome of cilia.    . 
+PF07163 Pex26 protein<br>Pfam-B_16379 (release 10.0). This family consists of Pex26 and related mammalian proteins. Pex26 is a type II peroxisomal membrane protein which recruits Pex6-Pex1 complexes to peroxisomes  . Mutations in Pex26 can lead to human disorders  .. 
+PF07165 Protein of unknown function (DUF1397)<br>Pfam-B_16395 (release 10.0). This family consists of several insect specific proteins. Swiss:Q25513 is annotated as being a haemolymph glycoprotein precursor. The function of this family is unknown  .. 
+PF07166 Protein of unknown function (DUF1398)<br>Pfam-B_16404 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Escherichia coli and Salmonella species. The function of this family is unknown.. 
+PF07167 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus<br>Pfam-B_16456 (release 10.0). This family represents the N-terminal region of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulfur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond  .  This family appears to be a partial segment of an alpha/beta hydrolase domain.. 
+PF07168 FAE_3-kCoA_syn1; Ureide_perm;<br>Pfam-B_11634 (release 10.0). Heterocyclic nitrogen compounds may serve as nitrogen sources or nitrogen transport compounds in plants that are not able to fix nitrogen. This family represents ureide permease, a transporter of a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine; it has 10 putative transmembrane domains with a large cytosolic central domain containing a 'Walker A' motif. Ureide permease is likely to transport other purine degradation products when nitrogen sources are low. Transport is dependent on glucose and a proton gradient  .  The family is found in bacteria, plants and yeast.. 
+PF07171 MlrC C-terminus<br>Pfam-B_6316 (release 10.0). This family represents the C-terminus (approximately 200 residues) of the product of a bacterial gene cluster that is involved in the degradation of the cyanobacterial toxin microcystin LR. Many members of this family are hypothetical proteins.. 
+PF07172 Glycine rich protein family<br>Pfam-B_15819 (release 10.0). This family of proteins includes several glycine rich proteins as well as two nodulins 16 and 24.  The family also contains proteins that are induced in response to various stresses.. 
+PF07173 Protein of unknown function (DUF1399)<br>Pfam-B_13062 (release 10.0). This family represents a conserved region approximately 150 residues long within a number of hypothetical plant proteins of unknown function.. 
+PF07174 Fibronectin-attachment protein (FAP)<br>Pfam-B_16585 (release 10.0). This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix  .. 
+PF07175 Osteoregulin<br>Pfam-B_16589 (release 10.0). This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition  .. 
+PF07176 Alpha/beta hydrolase of unknown function (DUF1400)<br>Pfam-B_16606 (release 10.0). This family contains a number of hypothetical proteins of unknown function that seem to be specific to cyanobacteria. Members of this family have an alpha/beta hydrolase fold.. 
+PF07177 Neuralized<br>Pfam-B_16611 (release 10.0). This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system  . Some family members contain multiple copies of this region.. 
+PF07178 TraL protein<br>Pfam-B_16378 (release 10.0). This family consists of several bacterial TraL proteins. TraL is a predicted peripheral membrane protein which is thought to be involved in bacterial sex pilus assembly  . The exact function of this family is unclear.. 
+PF07179 SseB protein N-terminal domain<br>Pfam-B_16678 (release 10.0). This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli   and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon  . This entry contains the presumed N-terminal domain of SseB.. 
+PF07180 Protein of unknown function (DUF1401)<br>Pfam-B_16789 (release 10.0). This family consists of several hypothetical bacterial proteins of around 135 residues in length. Members of this family appear to be found exclusively in the Enterobacteria Escherichia coli, Citrobacter rodentium and Salmonella typhi. The function of this family is unknown.. 
+PF07181 VirC2 protein<br>Pfam-B_16860 (release 10.0). This family consists of several VirC2 proteins which seem to be found exclusively in Agrobacterium species and Rhizobium etli. VirC2 is known to be involved in virulence in Agrobacterium species but its exact function is unclear [1,2].. 
+PF07182 Protein of unknown function (DUF1402)<br>Pfam-B_16561 (release 10.0). This family consists of several hypothetical bacterial proteins of around 310 residues in length. Members of this family seem to be found exclusively in Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.. 
+PF07183 Protein of unknown function (DUF1403)<br>Pfam-B_16581 (release 10.0). This family consists of several hypothetical bacterial proteins of around 320 residues in length. Members of this family are mainly found in Rhizobium and Agrobacterium species. The function of this family is unknown.. 
+PF07184 Citrus tristeza virus P33 protein<br>Pfam-B_16614 (release 10.0). This family consists of several Citrus tristeza virus (CTV) P33 proteins. The function of P33 is unclear although it is known that the protein is not needed for virion formation  .. 
+PF07185 Protein of unknown function (DUF1404)<br>Pfam-B_16616 (release 10.0). This family consists of several archaeal proteins of around 180 residues in length. Members of this family seem to be found exclusively in Sulfolobus tokodaii and Sulfolobus solfataricus. The function of this family is unknown.. 
+PF07187 Protein of unknown function (DUF1405)<br>Pfam-B_16845 (release 10.0). This family consists of several bacterial and related archaeal protein of around 180 residues in length. The function of this family is unknown.. 
+PF07188 Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein<br>Pfam-B_16868 (release 10.0). This family consists of Kaposi's sarcoma-associated herpesvirus (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerises. K8 interacts and co-localises with human Pfam:PF04855, a cellular chromatin-remodelling factor, both in vivo and in vitro. K8 is thought to function as a transcriptional activator under specific conditions and its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5  . . 
+PF07189 Splicing factor 3B subunit 10 (SF3b10)<br>Pfam-B_16870 (release 10.0). This family consists of several eukaryotic splicing factor 3B subunit 10 (SF3b10) proteins. SF3b10 is a 10 kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a and a 12S RNA unit to form the  U2 small nuclear ribonucleoproteins complex. SF3b10 and SF3b14b are also thought to facilitate the interaction of U2 with the branch site  .. 
+PF07190 Protein of unknown function (DUF1406)<br>Pfam-B_16883 (release 10.0). This family consists of several Orthopoxvirus proteins of around 185 resides in length. Members of this family seem to be exclusive to Vaccinia, Camelpox and Cowpox viruses. Some family members are annotated as being C8 proteins but their function is unknown.. 
+PF07191 DUF1407;<br>Pfam-B_16889 (release 10.0). This family consists of several short, hypothetical bacterial proteins of around 70 residues in length. Members of this family have 8 highly conserved cysteine residues, which form two zinc ribbon domains.. 
+PF07192 SNURF/RPN4 protein<br>Pfam-B_16890 (release 10.0). This family consists of several mammalian SNRPN upstream reading frame (SNURF) proteins. SNURF or RPF4 is a RING-finger protein and a coregulator of androgen receptor-dependent transcription. It has been suggested that  SNURF is involved in the regulation of processes required for late steps of spermatid maturation [1,2].. 
+PF07193 Protein of unknown function (DUF1408)<br>Pfam-B_16879 (release 10.0). This family consists of several hypothetical Lactococcus lactis and related phage proteins of around 75 residues in length. The function of this family is unknown.. 
+PF07194 P2 response regulator binding domain<br>Pfam-B_7970 (release 10.0). The response regulators for CheA bind to the P2 domain, which is found between Pfam:PF01627 and Pfam:PF02895 as either one or two copies.  Highly flexible linkers connect P2 to the  rest of CheA and impart remarkable mobility to the P2 domain. This feature is thought to enhance the inter CheA dimer phosphotransfer  reactions within the signalling complex, thereby amplifying the phosphorylation signal  .. 
+PF07195 Flagellar hook-associated protein 2 C-terminus<br>The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria  . This alignment covers the C-terminal region of this family of proteins.. 
+PF07196 Flagellin hook IN motif<br>The function of this region is not clear, but it is found in many flagellar hook proteins, including FliD homologues ( ). It is normally repeated, but is also apparently seen as a singleton. A conserved IN is seen at the centre of the motif. The diversity of these motifs makes it likely that some members of the family are not identified.. 
+PF07197 Protein of unknown function (DUF1409)<br>Pfam-B_16557 (release 10.0). This family represents a short conserved region (approximately 50 residues long), sometimes repeated, within a number of hypothetical Oryza sativa proteins of unknown function.. 
+PF07198 Protein of unknown function (DUF1410)<br>Pfam-B_13132 (release 10.0). This family represents a conserved domain approximately 100 residues long, multiple copies of which are found within hypothetical Ureaplasma parvum proteins of unknown function, as well as related species.. 
+PF07199 Protein of unknown function (DUF1411)<br>Pfam-B_16764 (release 10.0). This family represents a conserved region approximately 150 residues long that is sometimes repeated within some Babesia bovis proteins of unknown function.. 
+PF07200 Modifier of rudimentary (Mod(r)) protein<br>Vella Briffa B, Wood V, Mistry J. Pfam-B_16631 (release 10.0). This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic  , and both of these regions are represented in this family.  Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB).  The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37).  The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors  .. 
+PF07201 HrpJ-like domain<br>Pfam-B_16649 & Pfam-B_11026(release 10.0) & Pfam-B_1285(release 5.4). This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells  .  This family also includes the InvE invasion protein from Salmonella.  This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive  .  InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalisation of S. typhimurium into epithelial cells  . This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB  . SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system  .. 
+PF07202 T-complex protein 10 C-terminus<br>Pfam-B_13039 (release 10.0). This family represents the C-terminus (approximately 180 residues) of eukaryotic T-complex protein 10. The T-complex is involved in spermatogenesis in mice  .. 
+PF07203 Protein of unknown function (DUF1412)<br>Pfam-B_16907 (release 10.0). This family consists of several Caenorhabditis elegans proteins of around 70-75 residues in length. The function of this family is unknown.. 
+PF07204 Orthoreovirus membrane fusion protein p10<br>Pfam-B_16940 (release 10.0). This family consists of several Orthoreovirus membrane fusion protein p10 sequences.  p10 is thought to be a multifunctional protein that plays a key role in virus-host interaction  . . 
+PF07205 Domain of unknown function (DUF1413)<br>Pfam-B_16942 (release 10.0). This family consists of several hypothetical bacterial proteins which seem to be specific to firmicute species. Members of this family are typically around 100 residues in length. The function of this family is unknown.. 
+PF07206 Baculovirus late expression factor 10 (LEF-10)<br>Pfam-B_16893 (release 10.0). This family consists of several Baculovirus specific late expression factor 10 (LEF-10) sequences. LEF-10 is thought to be a late expressed structural protein although its exact function is unknown  .. 
+PF07207 Light regulated protein Lir1<br>Pfam-B_16937 (release 10.0). This family consists of several plant specific light regulated Lir1 proteins.\.  Lir1 mRNA accumulates in the light, reaching maximum and minimum steady-state levels at the end of the light and dark period, respectively. Plants germinated in the dark have very low levels of lir1 mRNA, whereas plants germinated in continuous light express lir1 at an intermediate but constant level. It is thought that lir1 expression is controlled by light and a circadian clock.  The exact function of this family is unclear  .. 
+PF07208 Protein of unknown function (DUF1414)<br>Pfam-B_16906 (release 10.0). This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.. 
+PF07209 Protein of unknown function (DUF1415)<br>Pfam-B_16932 (release 10.0). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.. 
+PF07210 Protein of unknown function (DUF1416)<br>Pfam-B_16939 (release 10.0). This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family appear to be Actinomycete specific. The function of this family is unknown.. 
+PF07212 Hyaluronidase; <br>Hyaluronidase protein (HylP). Pfam-B_16578 (release 10.0). This family consists of several phage associated hyaluronidase proteins (EC:3.2.1.35) which seem to be specific to Streptococcus pyogenes and Streptococcus pyogenes bacteriophages. The substrate of hyaluronidase is hyaluronic acid, a sugar polymer composed of alternating N-acetylglucosamine and glucuronic acid residues. Hyaluronic acid is found in the ground substance of human connective tissue and the vitreous of the eye and also is the sole component of the capsule of group A streptococci. The capsule has been shown to be an important virulence factor of this organism by virtue of its ability to resist phagocytosis. Production by S. pyogenes of both a hyaluronic acid capsule and hyaluronidase enzymatic activity capable of destroying the capsule is an interesting, yet-unexplained, phenomenon  .. 
+PF07213 DAP10 membrane protein<br>Pfam-B_16910 (release 10.0). This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells  .. 
+PF07214 Protein of unknown function (DUF1418)<br>Pfam-B_16971 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 100 residues in length. Members of this family are often described as YbjC. In E. coli the ybjC gene is located downstream of nfsA (which encodes the major oxygen-insensitive nitroreductase). It is thought that nfsA and ybjC form an operon an its promoter is  a class I SoxS-dependent promoter  . The function of this family is unknown.. 
+PF07215 Protein of unknown function (DUF1419)<br>Pfam-B_16972 (release 10.0). This family consists of several bacterial proteins of around 110 residues in length. Members of this family seem to be specific to Agrobacterium species and to Rhizobium loti. The function of this family is unknown.. 
+PF07216 LcrG protein<br>Pfam-B_16974 (release 10.0). This family consists of several bacterial LcrG proteins. Yersiniae are equipped with the Yop virulon, an apparatus that allows extracellular bacteria to deliver toxic Yop proteins inside the host cell cytosol in order to sabotage the communication networks of the host cell or even to cause cell death. LcrG is a component of the Yop virulon involved in the regulation of secretion of the Yops  .  . 
+PF07217 Heterokaryon incompatibility protein Het-C<br>Pfam-B_16951 (release 10.0). In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an individual colony to form a network. Hyphal fusion can occur also between different individuals to form a heterokaryon, in which genetically distinct nuclei occupy a common cytoplasm. However, heterokaryotic cells are viable only if the individuals involved have identical alleles at all het loci  .  . 
+PF07218 Rhoptry-associated protein 1 (RAP-1)<br>Pfam-B_16981 (release 10.0). This family consists of several rhoptry-associated protein 1 (RAP-1) sequences which appear to be specific to Plasmodium falciparum  .. 
+PF07219 HemY protein N-terminus<br>Pfam-B_16745 (release 10.0). This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis  .. 
+PF07220 Protein of unknown function (DUF1420)<br>Pfam-B_17056 (release 10.0). This family consists of several hypothetical putative lipoproteins which seem to be found specifically in the bacterium Leptospira interrogans. Members of this family are typically around 670 resides in length and their function is unknown.. 
+PF07221 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)<br>Pfam-B_17012 (release 10.0). This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.. 
+PF07222 Proacrosin binding protein sp32<br>Pfam-B_17278 (release 10.0). This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix  . . 
+PF07223 Protein of unknown function (DUF1421)<br>Pfam-B_17006 (release 10.0). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.. 
+PF07224 Chlorophyllase<br>Pfam-B_17130 (release 10.0). This family consists of several plant specific Chlorophyllase proteins (EC:3.1.1.14). Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyses the hydrolysis of ester bond to yield chlorophyllide and phytol  .. 
+PF07225 NDUFB4; <br>NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4). Pfam-B_17132 (release 10.0). This family consists of several NADH-ubiquinone oxidoreductase B15 subunit proteins (EC:1.6.5.3). . 
+PF07226 Protein of unknown function (DUF1422)<br>Pfam-B_17087 (release 10.0). This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.. 
+PF07227 Protein of unknown function (DUF1423)<br>Pfam-B_17028 (release 10.0). This family represents a conserved region approximately 500 residues long within a number of Arabidopsis thaliana proteins of unknown function.. 
+PF07228 Stage II sporulation protein E (SpoIIE)<br>Pfam-B_17063 (release 10.0). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments  .. 
+PF07229 VirE2<br>Pfam-B_17380 (release 10.0). This family consists of several VirE2 proteins which seem to be specific to Agrobacterium tumefaciens and Rhizobium etli. VirE2 is known to interact, via its C terminus, with VirD4. Agrobacterium tumefaciens transfers oncogenic DNA and effector proteins to plant cells during the course of infection. Substrate translocation across the bacterial cell envelope is mediated by a type IV secretion (TFS) system composed of the VirB proteins, as well as VirD4, a member of a large family of inner membrane proteins implicated in the coupling of DNA transfer intermediates to the secretion machine. VirE2 is therefore thought to be a protein substrate of a type IV secretion system which is recruited to a member of the coupling protein superfamily  . . 
+PF07230 Phage_T4_Gp20;<br>Bacteriophage T4-like capsid assembly protein (Gp20). Pfam-B_17388 (release 10.0). This family consists of several bacteriophage T4-like capsid assembly (or portal) proteins. The exact mechanism by which the double-stranded (ds) DNA bacteriophages incorporate the portal protein at a unique vertex of the icosahedral capsid is unknown. In phage T4, there is evidence that this vertex, constituted by 12 subunits of gp20, acts as an initiator for the assembly of the major capsid protein and the scaffolding proteins into a prolate icosahedron of precise dimensions. The regulation of portal protein gene expression is an important regulator of prohead assembly in bacteriophage T4  . This family represents the protease responsible for the proteolysis of head proteins, a critical step in the morphogenesis of many tailed phages, Cleavage facilitates the conversion of the prohead to the mature capsid. All these cleavages are carried out by action at consensus S/A/G-X-E recognition sequences at 39 cleavage sites. Evidence of multiple processing sites in nine phiKZ proteins appears to represent a built-in mechanism by which the phage ensures that the majority of the propeptide regions are removed, and emphasizes the essential nature of processing in phiKZ-head morphogenesis  . The family is classified by MEROPS as a serine peptidase.. 
+PF07231 Nematode_res_N; <br>Pfam-B_17124 (release 10.0). This family represents the N-terminus (approximately 180 residues) of plant Hs1pro-1, which is believed to confer resistance to nematodes  .. 
+PF07232 Putative rep protein (DUF1424)<br>Pfam-B_17284 (release 10.0). This family consists of several archaeal proteins of around 320 residues in length. Members of this family seem to be found exclusively in Halobacterium and Haloferax species. The function of this family is unknown. This protein is probably a rep protein due to conservation of functional motifs.. 
+PF07233 Protein of unknown function (DUF1425)<br>Pfam-B_17314 (release 10.0). This family consists of several hypothetical bacterial proteins of around 125 residues in length. Several members of this family are described as putative lipoproteins and are often known as YcfL. The function of this family is unknown.. 
+PF07234 Protein of unknown function (DUF1426)<br>Pfam-B_17431 (release 10.0). This family consists of several Banana bunchy top virus proteins of around 120 residues in length. Swiss:Q9IGU4 is annotated a movement protein whereas most other family members are hypothetical. The function of this family is unknown.. 
+PF07235 Protein of unknown function (DUF1427)<br>Pfam-B_17474 (release 10.0). This family consists of several bacterial proteins of around 100 residues in length. The function of this family is unknown.. 
+PF07236 Phytoreovirus S7 protein<br>Pfam-B_17475 (release 10.0). This family consists of several Phytoreovirus S7 proteins which are thought to be viral core proteins  .. 
+PF07237 Protein of unknown function (DUF1428)<br>Pfam-B_17402 (release 10.0). This family consists of several hypothetical bacterial and one archaeal sequence of around 120 residues in length. The function of this family is unknown.. 
+PF07238 PilZ domain<br>Pfam-B_17421 (release 10.0). PilZ is a c-di-GMP binding domain   which is found C terminal to Pfam:PF07317.  Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias  .  This domain forms a beta barrel structure.. 
+PF07239 Outer membrane protein OpcA<br>Pfam-B_17433 (release 10.0). This family consists of several Neisseria species specific OpcA outer membrane proteins. Opc (formerly called 5C) is one of the major outer membrane proteins and has been shown to play an important role in meningococcal adhesion and invasion of both epithelial and endothelial cells  .. 
+PF07240 Stress-inducible humoral factor Turandot<br>Pfam-B_17438 (release 10.0). This family consists of several Drosophila species specific Turandot proteins. The Turandot A (TotA) gene encodes a humoral factor, which is secreted from the fat body and accumulates in the body fluids. TotA is strongly induced upon bacterial challenge, as well as by other types of stress such as high temperature, mechanical pressure, dehydration, UV irradiation, and oxidative agents. It is also up-regulated during metamorphosis and at high age. Flies that over-express TotA show prolonged survival and retain normal activity at otherwise lethal temperatures. Although TotA is only induced by severe stress, it responds to a much wider range of stimuli than heat shock genes such as hsp70 or immune genes such as Cecropin A1  .. 
+PF07242 Protein of unknown function (DUF1430)<br>Pfam-B_17033 (release 10.0). This family represents the C-terminus (approximately 120 residues) of a number of hypothetical bacterial proteins of unknown function. These are possibly membrane proteins involved in immunity.. 
+PF07243 Phlebovirus glycoprotein G1<br>Pfam-B_17508 (release 10.0). This family consists of several Phlebovirus glycoprotein G1 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi  .. 
+PF07244 Surface antigen variable number repeat<br>This family is found primarily in bacterial surface antigens, normally as variable number repeats at the N-terminus. The C-terminus of these proteins is normally represented by Pfam:PF01103. The alignment centres on a -GY- or -GF- motif. Some members of this family are found in the mitochondria. It is predicted to have a mixed alpha/beta secondary structure.. 
+PF07245 Phlebovirus glycoprotein G2<br>Pfam-B_17508 (release 10.0). This family consists of several Phlebovirus glycoprotein G2 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi  .. 
+PF07246 Phlebovirus nonstructural protein NS-M<br>Pfam-B_17508 (release 10.0). This family consists of several Phlebovirus nonstructural NS-M proteins which represent the N-terminal region of the M polyprotein precursor. The function of this family is unknown.. 
+PF07247 Alcohol acetyltransferase<br>Pfam-B_17349 (release 10.0). This family contains a number of alcohol acetyltransferase (EC:2.3.1.84) enzymes approximately 500 residues long found in both bacteria and metazoa. These catalyse the esterification of isoamyl alcohol by acetyl coenzyme A  .. 
+PF07248 Protein of unknown function (DUF1431)<br>Pfam-B_17470 (release 10.0). This family contains a number of Drosophila melanogaster proteins of unknown function. These contain several conserved cysteine residues.. 
+PF07249 Cerato-platanin<br>Pfam-B_17594 (release 10.0). This family contains a number of fungal cerato-platanin phytotoxic proteins approximately 150 residues long. Cerato-platanin contains four cysteine residues that form two disulphide bonds  .. 
+PF07250 Glyoxal oxidase N-terminus<br>Pfam-B_17519 (release 10.0). This family represents the N-terminus (approximately 300 residues) of a number of plant and fungal glyoxal oxidase enzymes. Glyoxal oxidase catalyses the oxidation of aldehydes to carboxylic acids, coupled with reduction of dioxygen to hydrogen peroxide. It is an essential component of the extracellular lignin degradation pathways of the wood-rot fungus Phanerochaete chrysosporium  .. 
+PF07252 Protein of unknown function (DUF1433)<br>Pfam-B_17690 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.. 
+PF07253 Gypsy protein<br>Pfam-B_17444 (release 10.0). This family consists of several Gypsy/Env proteins from Drosophila and Ceratitis fruit fly species. Gypsy is an endogenous retrovirus of Drosophila melanogaster. Phylogenetic studies suggest that occasional horizontal transfer events of gypsy occur between Drosophila species.  Gypsy possesses infective properties associated with the products of the envelope gene that might be at the origin of these interspecies transfers  . This family contains many members with full-length matches; however, it also includes a number of very short sequences and short matches of sequences with other unrelated domains on them, which cannot be excluded. These matches may represent remnants of once-functional genes.. 
+PF07254 Protein of unknown function (DUF1434)<br>Pfam-B_17586 (release 10.0). This family consists of several hypothetical bacterial proteins of around 135 residues in length. Members of this family all appear to be Enterobacterial proteins. The function of this family is unknown.. 
+PF07255 Benyvirus 14KDa protein<br>Pfam-B_17595 (release 10.0). This family consists of several Benyvirus specific 14KDa proteins of around 125 residues in length. Members of this family contain 9 conserved cysteine residues. The function of this family is unknown.. 
+PF07256 Protein of unknown function (DUF1435)<br>Pfam-B_17631 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.. 
+PF07258 HCaRG protein<br>Pfam-B_17801 (release 10.0). This family consists of several mammalian HCaRG(hypertension-related, calcium-regulated gene) proteins. HCaRG is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. HCaRG is a nuclear protein potentially involved in the control of cell proliferation  . . 
+PF07259 ProSAAS precursor<br>Pfam-B_17813 (release 10.0). This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1   may function as a neuropeptide  . N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease  .. 
+PF07260 Progressive ankylosis protein (ANKH)<br>Pfam-B_17517 (release 10.0). This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralisation and bone resorption  . Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterised by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones  .. 
+PF07261 Replication initiation and membrane attachment<br>Pfam-B_17543 (release 10.0). This family consists of several bacterial replication initiation and membrane attachment (DnaB) proteins, as well as DnaD which is a component of the PriA primosome.  The PriA primosome functions to recruit the replication fork helicase onto the DNA  . The DnaB protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110 in Bacillus subtilis. It is known that there are two different classes (DnaBI and DnaBII) in the DnaB mutants; DnaBI is essential for both chromosome and pUB110 replication, whereas DnaBII is necessary only for chromosome replication  . DnaD has been merged into this family. This family also includes Ftn6, a cyanobacterial-specific divisome component possibly playing a role at the interface between DNA replication and cell division  . Ftn6 possesses a conserved domain localised within the N-terminus of the proteins. This domain, named FND, exhibits sequence and structure similarities with the DnaD-like domains Pfam:PF04271 now merged into Pfam:PF07261.. 
+PF07262 Protein of unknown function (DUF1436)<br>Pfam-B_17809 (release 10.0). This family consists of several hypothetical bacterial proteins of around 160 residues in length. The function of this family is unknown.. 
+PF07263 Dentin matrix protein 1 (DMP1)<br>Pfam-B_17812 (release 10.0). This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21  . DMP1 is a bone and teeth specific protein initially identified from mineralised dentin.  DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation  . The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown  .. 
+PF07264 Etoposide-induced protein 2.4 (EI24)<br>Pfam-B_17540 (release 10.0). This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53  . It has been suggested to play an important role in negative cell growth control  .. 
+PF07265 Tapetum specific protein TAP35/TAP44<br>Pfam-B_17587 (release 10.0). This family consists of several plant tapetum specific proteins. Members of this family are found in Arabidopsis thaliana, Brassica napus and Sinapis alba. Members of this family may be involved in sporopollenin formation and/or deposition  .. 
+PF07267 Nucleopolyhedrovirus capsid protein P87<br>Pfam-B_17842 (release 10.0). This family consists of several Nucleopolyhedrovirus capsid protein P87 sequences. P87 is expressed late in infection and concentrated in infected cell nuclei  .. 
+PF07268 Exported protein precursor (EppA/BapA)<br>Pfam-B_17945 (release 10.0). This family consists of a number of exported protein precursor (EppA and BapA) sequences which seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). bapA gene sequences are quite stable but the encoded proteins do not provoke a strong immune response in most individuals. Conversely, EppA proteins are much more antigenic but are more variable in sequence. It is thought that BapA and EppA play important roles during the Borrelia burgdorferi infectious cycle  .. 
+PF07270 Protein of unknown function (DUF1438)<br>Pfam-B_18024 (release 10.0). This family consists of several hypothetical proteins of around 170 residues in length which appear to be mouse specific. The function of this family is unknown.. 
+PF07271 Cytadhesin P30/P32<br>Pfam-B_18052 (release 10.0). This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localised on the tip organelle. It is thought that it is important in cytadherence and virulence  .. 
+PF07272 Orthoreovirus P17 protein<br>Pfam-B_18125 (release 10.0). This family consists of several Orthoreovirus P17 proteins. P17 is specified be ORF2 of the S1 gene and represents a nonstructural protein which associate with cell membranes  .. 
+PF07273 Protein of unknown function (DUF1439)<br>Pfam-B_18280 (release 10.0). This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.. 
+PF07274 Protein of unknown function (DUF1440)<br>Pfam-B_17831 (release 10.0). This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.. 
+PF07275 Antirestriction protein (ArdA)<br>Pfam-B_17857 (release 10.0). This family consists of several bacterial antirestriction (ArdA) proteins.\.       ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification  .. 
+PF07276 Apopolysialoglycoprotein (PSGP)<br>Pfam-B_17916 (release 10.0). This family represents a series of 13 reside repeats found in the apopolysialoglycoprotein of Oncorhynchus mykiss (Rainbow trout) and Oncorhynchus masou (Cherry salmon). Polysialoglycoprotein (PSGP) of unfertilised eggs of rainbow trout consists of tandem repeats of a glycotridecapeptide, Asp-Asp-Ala-Thr*-Ser*-Glu-Ala-Ala-Thr*-Gly-Pro-Ser- Gly (* denotes the attachment site of a polysialoglycan chain). In response to egg activation, PSGP is discharged by exocytosis into the space between the vitelline envelope and the plasma membrane, i.e. the perivitelline space, where the 200-kDa PSGP molecules undergo rapid and dramatic depolymerisation by proteolysis into glycotridecapeptides  .. 
+PF07277 SapC<br>Pfam-B_17881 (release 10.0). This family contains a number of bacterial SapC proteins approximately 250 residues long. In Campylobacter fetus, SapC forms part of a paracrystalline surface layer (S-layer) that confers serum resistance  .. 
+PF07278 Protein of unknown function (DUF1441)<br>Pfam-B_17966 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 160 residues in length. The function of this family is unknown. However, it appears to be distantly related to other HTH families so may act as a transcriptional regulator.. 
+PF07279 Protein of unknown function (DUF1442)<br>Pfam-B_18012 (release 10.0). This family consists of several hypothetical Arabidopsis thaliana proteins of around 225 residues in length. The function of this family is unknown.. 
+PF07280 Protein of unknown function (DUF1443)<br>Pfam-B_18027 (release 10.0). This family consists of several Baculovirus proteins of around 55 residues in length. The function of this family is unknown.. 
+PF07281 Insulin-induced protein (INSIG)<br>Pfam-B_17905 (release 10.0). This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations [1,2].. 
+PF07282 Transposase_35;<br>Putative transposase DNA-binding domain. Pfam-B_4755 (release 10.0). This putative domain is found at the C-terminus of a large number of transposase proteins.  This domain contains four conserved cysteines suggestive of a zinc binding domain.  Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesise this domain is DNA-binding.. 
+PF07283 Conjugal transfer protein TrbH<br>Pfam-B_17942 (release 10.0). This family contains TrbH, a bacterial conjugal transfer protein approximately 150 residues long. This contains a putative membrane lipoprotein lipid attachment site  .. 
+PF07284 2-vinyl bacteriochlorophyllide hydratase (BCHF)<br>Pfam-B_17961 (release 10.0). This family contains the bacterial enzyme 2-vinyl bacteriochlorophyllide hydratase (EC:4.2.1.-) (approximately 150 residues long). This is involved in the light-independent bacteriochlorophyll biosynthesis pathway by adding water across the 2-vinyl group  .. 
+PF07285 Protein of unknown function (DUF1444)<br>Pfam-B_18053 (release 10.0). This family contains several hypothetical bacterial proteins of unknown function that are approximately 250 residues long.. 
+PF07286 Protein of unknown function (DUF1445)<br>Pfam-B_18180 (release 10.0). This family represents a conserved region approximately 150 residues long within a number of hypothetical bacterial and eukaryotic proteins of unknown function.. 
+PF07287 Protein of unknown function (DUF1446)<br>Pfam-B_17949 (release 10.0). This family consists of several bacterial and plant proteins of around 400 residues in length. The function of this family is unknown.. 
+PF07288 Protein of unknown function (DUF1447)<br>Pfam-B_18163 (release 10.0). This family consists of several bacterial proteins of around 70 residues in length. The function of this family is unknown.. 
+PF07289 Protein of unknown function (DUF1448)<br>Pfam-B_18223 (release 10.0). This family consists of several eukaryotic proteins of around 375 residues in length. The function of this family is unknown. It appears that this family includes a divergent GRAM domain.. 
+PF07290 Protein of unknown function (DUF1449)<br>Pfam-B_18269 (release 10.0). This family consists of several bacterial proteins of around 210 residues in length. The function of this family is unknown.. 
+PF07291 Methylamine utilisation protein MauE<br>Pfam-B_18306 (release 10.0). This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded  .. 
+PF07292 Nmi/IFP 35 domain (NID)<br>Pfam-B_17864 (release 10.0). This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localisation  .. 
+PF07293 Protein of unknown function (DUF1450)<br>Pfam-B_18439 (release 10.0). This family consists of several hypothetical bacterial proteins of around 80 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.. 
+PF07294 Fibroin P25<br>Pfam-B_18451 (release 10.0). This family consists of several insect fibroin P25 proteins. Silk fibroin produced by the silkworm Bombyx mori consists of a heavy chain, a light chain, and a glycoprotein, P25. The heavy and light chains are linked by a disulfide bond, and P25 associates with disulfide-linked heavy and light chains by non-covalent interactions. P25 is plays an important role in maintaining integrity of the complex  .. 
+PF07295 Protein of unknown function (DUF1451)<br>Pfam-B_18524 (release 10.0). This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein. The function of this family is unknown.. 
+PF07296 TraP protein<br>Pfam-B_18635 (release 10.0). This family consists of several bacterial conjugative transfer TraP proteins from Escherichia coli and Salmonella typhimurium. TraP appears to play a minor role in conjugation and may interact with TraB, which varies in sequence along with TraP, in order to stabilise the proposed transmembrane complex formed by the tra operon products  .. 
+PF07297 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)<br>Pfam-B_18649 (release 10.0). This family consists of several eukaryotic dolichol phosphate-mannose biosynthesis regulatory (DPM2) proteins. Biosynthesis of glycosylphosphatidylinositol and N-glycan precursor is dependent upon a mannosyl donor, dolichol phosphate-mannose (DPM). DPM2, an 84 amino acid membrane protein expressed in the endoplasmic reticulum (ER), makes a complex with DPM1 that is essential for the ER localisation and stable expression of DPM1. Moreover, DPM2 enhances binding of dolichol phosphate, a substrate of DPM synthase. Biosynthesis of DPM in mammalian cells is regulated by DPM2  .. 
+PF07298 NnrU protein<br>Pfam-B_18406 (release 10.0). This family consists of several plant and bacterial NnrU proteins. NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that  NnrU and perhaps NnrT are required for expression of both nirK and nor  .. 
+PF07299 Fibronectin-binding protein (FBP)<br>Pfam-B_18450 (release 10.0). This family consists of several bacterial fibronectin-binding proteins which are thought to be involved in virulence in Listeria species [1,2].. 
+PF07301 Protein of unknown function (DUF1453)<br>Pfam-B_18607 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.. 
+PF07302 AroM protein<br>Pfam-B_18608 (release 10.0). This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL  . The function of this family is unknown.. 
+PF07303 Occludin homology domain<br>Pfam-B_18556 (release 10.0). This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localises to tight junctions  , while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA  . This shared domain is thought to mediate protein interactions  .. 
+PF07304 Steroid receptor RNA activator (SRA1)<br>Pfam-B_18506 (release 10.0). This family consists of several hypothetical mammalian steroid receptor RNA activator proteins. SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines. SRA-RNA is a steroid receptor co-activator which acts as a functional RNA and is classified as belonging to the growing family of functional non-coding RNAs. . 
+PF07305 Protein of unknown function (DUF1454)<br>Pfam-B_18833 (release 10.0). This family consists of several Enterobacterial sequences of around 200 residues in length which are often known as YiiQ proteins. The function of this family is unknown.. 
+PF07306 Protein of unknown function (DUF1455)<br>Pfam-B_19038 (release 10.0). This family consists of several hypothetical putative outer membrane proteins which appear to be specific to Anaplasma marginale and Anaplasma ovis.. 
+PF07307 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1<br>Pfam-B_18592 (release 10.0). This family contains subunit 1 of bacterial heptaprenyl diphosphate synthase (HEPPP synthase) (EC:2.5.1.30) (approximately 230 residues long). The enzyme consists of two subunits, both of which are required for catalysis of heptaprenyl diphosphate synthesis  .. 
+PF07308 Protein of unknown function (DUF1456)<br>This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.. 
+PF07309 Flagellar protein FlaF<br>Pfam-B_19331 (release 10.0). This family consists of several bacterial FlaF flagellar proteins. FlaF and FlaG are trans-acting, regulatory factors that modulate flagellin synthesis during flagellum biogenesis  .. 
+PF07310 DUF1457; <br>Pfam-B_18761 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. This region is is distantly similar to other PAS domains.. 
+PF07311 DUF1458;<br>Moxon SJ, Anantharaman V. Pfam-B_18876 (release 10.0). Dodecin is a flavin-binding protein  ,found in several bacteria and  few archaea and represents a stand-alone version of the SHS2  domain  . It most closely resembles the SHS2 domains of FtsA and  Rpb7p, and represents a single domain small-molecule binding form .. 
+PF07312 Protein of unknown function (DUF1459)<br>Pfam-B_18877 (release 10.0). This family consists of several hypothetical Caenorhabditis elegans proteins of around 85 residues in length. The function of this family is unknown.. 
+PF07313 Protein of unknown function (DUF1460)<br>Pfam-B_18925 (release 10.0). This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.. 
+PF07314 Protein of unknown function (DUF1461)<br>Pfam-B_18854 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. These are possibly integral membrane proteins.. 
+PF07315 Protein of unknown function (DUF1462)<br>Pfam-B_19094 (release 10.0). This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.. 
+PF07316 Protein of unknown function (DUF1463)<br>Pfam-B_19113 (release 10.0). This family consists of several hypothetical bacterial proteins of around 140 residues in length. Members of this family seem to be found exclusively in Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.. 
+PF07317 Flagellar regulator YcgR<br>Pfam-B_19142 (release 10.0). This domain is found N terminal to Pfam:PF07238.  Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias  .. 
+PF07318 Protein of unknown function (DUF1464)<br>Pfam-B_19143 (release 10.0). This family consists of several hypothetical archaeal proteins of around 350 residues in length. The function of this family is unknown.. 
+PF07319 Primosomal protein DnaI N-terminus<br>Pfam-B_18931 (release 10.0). This family represents the N-terminus (approximately 120 residues) of bacterial primosomal DnaI proteins, although one family member appears to be of viral origin. DnaI is one of the components of the Bacillus subtilis replication restart primosome, and is required for the DnaB75-dependent loading of the DnaC helicase  .. 
+PF07321 Type III secretion protein YscO<br>Pfam-B_19036 (release 10.0). This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis  .. 
+PF07322 Seadornavirus Vp10<br>Pfam-B_18930 (release 10.0). This family consists of several Seadornavirus Vp10 proteins found in the Banna and Kadipiro viruses. Members of this family are typically around 240 residues in length. The function of this family is unknown.. 
+PF07323 Protein of unknown function (DUF1465)<br>Pfam-B_19346 (release 10.0). This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.. 
+PF07324 DiGeorge syndrome critical region 6 (DGCR6) protein<br>Pfam-B_19101 (release 10.0). This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome  . Also found in this family is the Drosophila melanogaster gonadal protein gdl.. 
+PF07325 Curtovirus V2 protein<br>Pfam-B_19350 (release 10.0). This family consists of several Curtovirus V2 proteins. The exact function of V2 is unclear but it is known that the protein is required for a successful host infection process  .. 
+PF07326 Protein of unknown function (DUF1466)<br>Pfam-B_19433 (release 10.0). This family consists of several hypothetical mammalian proteins of around 240 residues in length.. 
+PF07327 Neuroparsin<br>Pfam-B_19487 (release 10.0). This family consists of several locust specific neuroparsin proteins. Neuroparsins are produced by the A1 type of protocerebral median neurosecretory cells of the PI-CC system and display pleiotropic activities: inhibition of the effect of juvenile hormone, stimulation of fluid reabsorption of isolated recta, induction of an increase in hemolymph lipid and trehalose levels, and neurotrophic effects  .. 
+PF07328 T-DNA border endonuclease VirD1<br>Pfam-B_19558 (release 10.0). This family consists of several T-DNA border endonuclease VirD1 proteins which appear to be found exclusively in Agrobacterium species. Agrobacterium, a plant pathogen, is capable to stably transform the plant cell with a segment of its own DNA called T-DNA (transferred DNA). This process depends, among others, on the specialised bacterial virulence proteins VirD1 and VirD2 that excise the T-DNA from its adjacent sequences. VirD1 is thought to interact with VirD2 in this process  .. 
+PF07330 Protein of unknown function (DUF1467)<br>Pfam-B_19588 (release 10.0). This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.. 
+PF07331 DUF1468;<br>Tripartite tricarboxylate transporter TctB family. Pfam-B_19347 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.. 
+PF07332 Protein of unknown function (DUF1469)<br>Pfam-B_19352 (release 10.0) & COG5393. This family consists of several hypothetical bacterial proteins of around 140 residues in length. The function of this family is unknown.. 
+PF07333 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP)<br>Pfam-B_19392 (release 10.0). This family consists of a number of cysteine rich SLR1 binding pollen coat like proteins. Adhesion of pollen grains to the stigmatic surface is a critical step during sexual reproduction in plants. In Brassica, S locus-related glycoprotein 1 (SLR1), a stigma-specific protein belonging to the S gene family of proteins, has been shown to be involved in this step. SLR1-BP specifically binds SLR1 with high affinity. The SLR1-BP gene is specifically expressed in pollen at late stages of development and is a member of the class A pollen coat protein (PCP) family, which includes PCP-A1, an SLG (S locus glycoprotein)-binding protein  .. 
+PF07334 Interferon-induced 35 kDa protein (IFP 35) N-terminus<br>Pfam-B_17864 (release 10.0). This family represents the N-terminus of interferon-induced 35 kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an alpha helical configuration  . This family also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.. 
+PF07335 Chitosanase;<br>Fungal chitosanase of glycosyl hydrolase group 75. Pfam-B_19431 (release 10.0). This family consists of several fungal chitosanase proteins. Chitin, xylan, 6-O-sulphated chitosan and O-carboxymethyl chitin are indigestible by chitosanase  . EC:3.2.1.132. The mechanism is likely to be inverting, and the probable catalytic neutrophile base is Asp, with the probable catalytic proton donor being Glu. (see the Chitosanase web-page from CAZY).. 
+PF07336 Protein of unknown function (DUF1470)<br>Pfam-B_19432 (release 10.0). This family consists of several hypothetical bacterial proteins of around 180 residues in length. Members of this family are found in Streptomyces, Rhizobium, Ralstonia, Agrobacterium and Bradyrhizobium species. The function of this family is unknown.. 
+PF07337 DC-EC Repeat<br>This repeat is found in the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells ( ). It forms part of a surface needle structure, and this repeat may form an alpha-helical rod structure ( ). A conserved -DC- and -EC- can be seen in regularly spaced in the alignment.. 
+PF07338 Protein of unknown function (DUF1471)<br>Pfam-B_19452 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some members of this family are annotated as ydgH precursors and contain two copies of this region, one at the N-terminus and the other at the C-terminus. The function of this family is unknown.. 
+PF07339 Protein of unknown function (DUF1472)<br>Pfam-B_19493 (release 10.0). This family consists of several Enterobacterial proteins of around 125 residues in length and contains 6 highly conserved cysteine residues. The function of this family is unknown.. 
+PF07340 Cytomegalovirus IE1 protein<br>Pfam-B_22587 (release 10.0). Expression from a human cytomegalovirus early promoter (E1.7) has been shown to be activated in trans by the IE2 gene product. Although the IE1 gene product alone had no effect on this early viral promoter, maximal early promoter activity was detected when both IE1 and IE2 gene products were present  .  The IE1 protein from cytomegalovirus is also known as UL123.. 
+PF07341 Protein of unknown function (DUF1473)<br>Pfam-B_19856 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be found exclusively in Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.. 
+PF07342 Protein of unknown function (DUF1474)<br>Pfam-B_19882 (release 10.0). This family consists of several bacterial proteins of around 100 residues in length. Members of this family seem to be found exclusively in Staphylococcus aureus. The function of this family is unknown.. 
+PF07343 Protein of unknown function (DUF1475)<br>Pfam-B_19887 (release 10.0). This family consists of several hypothetical plant proteins of around 250 residues in length. Members of this family seem to be found exclusively in Arabidopsis thaliana. The function of this family is unknown.. 
+PF07344 Amastin surface glycoprotein<br>Pfam-B_19245 (release 10.0). This family contains the eukaryotic surface glycoprotein amastin (approximately 180 residues long).In Trypanosoma cruzi, amastin is particularly abundant during the amastigote stage.. 
+PF07345 Domain of unknown function (DUF1476)<br>Pfam-B_19680 (release 10.0). This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family are found in Bradyrhizobium, Rhizobium, Brucella and Caulobacter species. The function of this family is unknown.. 
+PF07346 Protein of unknown function (DUF1477)<br>Pfam-B_19762 (release 10.0). This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 100 resides in length. The function of this family is unknown.. 
+PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)<br>Pfam-B_19436 (release 10.0). This family contains the eukaryotic NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) (EC:1.6.5.3). This is approximately 100 residues long, and forms part of a multiprotein complex that resides on the inner mitochondrial membrane. The main function of the complex is the transport of electrons from NADH to ubiquinone, accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space  .. 
+PF07348 Syd protein (SUKH-2)<br>Vella Briffa B, Zhang D, Aravind L. Pfam-B_19909 (release 10.0). This family contains a number of bacterial Syd proteins approximately 180 residues long. It has been suggested that Syd is loosely associated with the cytoplasmic surface of the cytoplasmic membrane, and that interaction with SecY may be involved in this membrane association  . Operon analysis showed that Syd protein may function as immunity protein in bacterial toxin systems  .. 
+PF07349 Protein of unknown function (DUF1478)<br>Pfam-B_20105 (release 10.0). This family consists of several hypothetical Sapovirus proteins of around 165 residues in length. The function of this family is unknown.. 
+PF07350 Protein of unknown function (DUF1479)<br>Pfam-B_20226 (release 10.0). This family consists of several hypothetical Enterobacterial proteins, of around 420 residues in length. Members of this family are often known as YbiU. The function of this family is unknown.. 
+PF07351 Protein of unknown function (DUF1480)<br>Pfam-B_20253 (release 10.0). This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.. 
+PF07352 Bacteriophage Mu Gam like protein<br>Pfam-B_19455 (release 10.0). This family consists of bacterial and phage Gam proteins. The gam gene of bacteriophage Mu encodes a protein which protects linear double stranded DNA from exonuclease degradation in vitro and in vivo  .. 
+PF07353 Uroplakin II<br>Pfam-B_19993 (release 10.0). This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension  .. 
+PF07354 Zona-pellucida-binding protein (Sp38)<br>Pfam-B_19996 (release 10.0). This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner  . These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilisation to occur  .. 
+PF07355 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)<br>Pfam-B_19711 (release 10.0). This family represents a conserved region approximately 350 residues long within the selenoprotein B component of the bacterial glycine, sarcosine and betaine reductase complexes.. 
+PF07356 Protein of unknown function (DUF1481)<br>Pfam-B_20042 (release 10.0). This family consists of several hypothetical bacterial proteins of around 230 residues in length. Members of this family are often referred to as YjaH and are found in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.. 
+PF07357 Dinitrogenase reductase ADP-ribosyltransferase (DRAT)<br>Pfam-B_20108 (release 10.0). This family consists of several bacterial dinitrogenase reductase ADP-ribosyltransferase (DRAT) proteins. Members of this family seem to be specific to Rhodospirillum, Rhodobacter and Azospirillum species. Dinitrogenase reductase ADP-ribosyl transferase (DRAT) carries out the transfer of the ADP-ribose from NAD to the Arg-101 residue of one subunit of the dinitrogenase reductase homodimer, resulting in inactivation of that enzyme. Dinitrogenase reductase-activating glycohydrolase (DRAG) removes the ADP-ribose group attached to dinitrogenase reductase, thus restoring nitrogenase activity. The DRAT-DRAG system negatively regulates nitrogenase activity in response to exogenous NH4+ or energy limitation in the form of a shift to darkness or to anaerobic conditions  .. 
+PF07358 Protein of unknown function (DUF1482)<br>Pfam-B_20128 (release 10.0). This family consists of several Enterobacterial proteins of around 60 residues in length. The function of this family is unknown.. 
+PF07359 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)<br>Pfam-B_20235 (release 10.0). This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cysteine-rich, and cationic protein. LEAP-2 contains a core structure with two disulfide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP-2 is synthesised as a 77-residue precursor, which is predominantly expressed in the liver and highly conserved among mammals. The largest native LEAP-2 form of 40 amino acid residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial model organisms  . The exact function of this family is unclear.. 
+PF07361 Cytochrome_b562;<br>Pfam-B_18074 (release 10.0). This family contains the bacterial cytochrome b562. This forms a four-helix bundle that non-covalently binds a single heme prosthetic group.  .. 
+PF07362 Post-segregation antitoxin CcdA<br>Pfam-B_20349 (release 10.0). This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein  .. 
+PF07363 Protein of unknown function (DUF1484)<br>Pfam-B_20389 (release 10.0). This family consists of several hypothetical bacterial proteins of around 110 residues in length. Members of this family appear to be found exclusively in Ralstonia solanacearum. The function of this family is unknown.. 
+PF07364 Protein of unknown function (DUF1485)<br>Pfam-B_20495 (release 10.0). This family consists of several hypothetical bacterial proteins of around 300 residues in length. Members of this family all appear to be in the Phylum Proteobacteria. The function of this family is unknown.. 
+PF07365 Alpha conotoxin precursor<br>Pfam-B_20562 (release 10.0). This family consists of several alpha conotoxin precursor proteins from a number of Conus species. The alpha-conotoxins are small peptide neurotoxins from the venom of fish-hunting cone snails which block nicotinic acetylcholine receptors (nAChRs)  . . 
+PF07366 DUF1486; <br>SnoaL-like polyketide cyclase. Pfam-B_20348 (release 10.0), Pfam-B_4335 (release 18.0). This family includes SnoaL   a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486.  The proteins in this family adopt a distorted alpha-beta barrel fold  .  Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation  .. 
+PF07367 Fungal fruit body lectin<br>Pfam-B_20370 (release 10.0). This family consists of several fungal fruit body lectin proteins. Fruit body lectins are thought to have insecticidal activity [1,2] and may also function in capturing nematodes  . . 
+PF07368 Protein of unknown function (DUF1487)<br>Pfam-B_20425 (release 10.0). This family consists of several uncharacterised proteins from Drosophila melanogaster. The function of this family is unknown.. 
+PF07369 Protein of unknown function (DUF1488)<br>Pfam-B_20604 (release 10.0). This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.. 
+PF07370 Protein of unknown function (DUF1489)<br>Pfam-B_20654 (release 10.0). This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be founds exclusively in the Class Alphaproteobacteria. The function of this family is unknown.. 
+PF07371 Protein of unknown function (DUF1490)<br>Pfam-B_20678 (release 10.0). This family consists of several hypothetical bacterial proteins of around 90 residues in length. Members of the family seem to be found exclusively in Mycobacterium species. The function of this family is unknown.. 
+PF07372 Protein of unknown function (DUF1491)<br>Pfam-B_20742 (release 10.0). This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in the Class Alphaproteobacteria. The function of this family is unknown.. 
+PF07373 CAMP factor (Cfa)<br>Pfam-B_20762 (release 10.0). This family consists of several bacterial CAMP factor (Cfa) proteins which seem to be specific to Streptococcus species. The CAMP reaction is a synergistic lysis of erythrocytes by the interaction of an extracellular protein (CAMP factor) produced by some streptococcal species with the Staphylococcus aureus sphingomyelinase C (beta-toxin)  . . 
+PF07374 Protein of unknown function (DUF1492)<br>Pfam-B_20776 (release 10.0). This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length.  The function of this family is unknown. It appears to be distantly related to Pfam:PF08281.. 
+PF07376 Prosystemin<br>Pfam-B_20835 (release 10.0). This family consists of several plant specific prosystemin proteins. Prosystemin is the precursor protein of the 18 amino acid wound signal systemin which activates systemic defence in plant leaves against insect herbivores  .. 
+PF07377 Protein of unknown function (DUF1493)<br>Pfam-B_20460 (release 10.0). This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in Salmonella and Yersinia species and several have been described as being putative cytoplasmic proteins. The function of this family is unknown.. 
+PF07378 Flagellar protein FlbT<br>Pfam-B_20574 (release 10.0). This family consists of several FlbT proteins. FlbT is a post-transcriptional regulator of flagellin. FlbT is associated with the 5' untranslated region (UTR) of fljK (25 kDa flagellin) mRNA and that this association requires a predicted loop structure in the transcript. Mutations within this loop abolish FlbT association and result in increased mRNA stability. It is therefore thought that FlbT promotes the degradation of flagellin mRNA by associating with the 5' UTR  .. 
+PF07379 Protein of unknown function (DUF1494)<br>Pfam-B_20601 (release 10.0). This family consists of several bacterial proteins of around 175 residues in length. Members of this family seem to be found exclusively in Chlamydia species. The function of this family is unknown.. 
+PF07380 Pneumovirus M2 protein<br>Pfam-B_20478 (release 10.0). This family consists of several Pneumovirus M2 proteins. The M2-1 protein of respiratory syncytial virus (RSV) is a transcription processivity factor that is essential for virus replication  .. 
+PF07381 Winged helix DNA-binding domain (DUF1495)<br>Pfam-B_20509 (release 10.0). This family consists of several hypothetical archaeal proteins of around 110 residues in length. The structure of this domain possesses a winged helix DNA-binding domain suggesting these proteins are bacterial transcription factors.. 
+PF07382 Histone H1-like nucleoprotein HC2<br>Pfam-B_20179 (release 10.0). This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has been suggested that it also has other roles  .. 
+PF07383 Protein of unknown function (DUF1496)<br>Pfam-B_20554 (release 10.0). This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.. 
+PF07384 Protein of unknown function (DUF1497)<br>Pfam-B_20585 (release 10.0). This family consists of several phage and bacterial proteins of around 59 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this organism. The function of this family is unknown.. 
+PF07385 Protein of unknown function (DUF1498)<br>Pfam-B_20610 (release 10.0). This family consists of several hypothetical bacterial proteins of around 225 residues in length. The function of this family is unknown.. 
+PF07386 Protein of unknown function (DUF1499)<br>Pfam-B_20643 (release 10.0). This family consists of several hypothetical bacterial and plant proteins of around 125 residues in length. The function of this family is unknown.. 
+PF07387 Seadornavirus VP7<br>Pfam-B_20657 (release 10.0). This family consists of several Seadornavirus specific VP7 proteins of around 305 residues in length. The function of this family is unknown. However, it appears to be distantly related to protein kinases.. 
+PF07388 Alpha-2,8-polysialyltransferase (POLYST)<br>Pfam-B_20294 (release 10.0). This family contains the bacterial enzyme alpha-2,8-polysialyltransferase (EC:2.4.99.-) (approximately 500 residues long). This catalyses the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA)  .. 
+PF07389 Protein of unknown function (DUF1500)<br>Pfam-B_20659 (release 10.0). This family consists of several Orthopoxvirus specific proteins of around 100 residues in length. The function of this family is unknown.. 
+PF07390 Mycoplasma P30 protein<br>Pfam-B_20617 (release 10.0). This family consists of several P30 proteins which seem to be specific to Mycoplasma agalactiae. P30 is a 30-kDa immunodominant antigen and is known to be a transmembrane protein  .. 
+PF07391 NPR nonapeptide repeat (2 copies)<br>This nine residue repeat which I have called NPR after NonaPeptide Repeat.  It is found in two malarial proteins and has the consensus EEhhEEhhP where h stands for a hydrophobic amino acid.. 
+PF07392 Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus<br>Pfam-B_20449 (release 10.0). This family represents the N-terminus (approximately 50 residues) of  cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis  .. 
+PF07393 Exocyst complex component Sec10<br>Pfam-B_20545 (release 10.0). This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which specifically affects the synthesis and delivery of secretory and basolateral plasma membrane proteins  .. 
+PF07394 Protein of unknown function (DUF1501)<br>Pfam-B_20578 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function approximately 400 residues long.. 
+PF07395 Mig-14<br>Pfam-B_20642 (release 10.0). This family contains a number of bacterial mig-14 proteins (approximately 270 residues long). In Salmonella, mig-14 contributes to resistance to antimicrobial peptides, although the mechanism is not fully understood  .. 
+PF07396 Phosphate-selective porin O and P<br>Pfam-B_20808 (release 10.0). This family represents a conserved region approximately 400 residues long within the bacterial phosphate-selective porins O and P. These are anion-specific porins, the binding site of which has a higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates, while porin P has a higher affinity for orthophosphate  . In P. aeruginosa, porin O was found to be expressed only under phosphate-starvation conditions during the stationary growth phase  .. 
+PF07397 Repeat of unknown function (DUF1502)<br>Pfam-B_20836 (release 10.0). This family consists of a number of repeats of around 34 residues in length. Members of this family seem to be found exclusively in three hypothetical Murid herpesvirus 4 proteins. The function of this family is unknown.. 
+PF07398 MDMPI C-terminal domain<br>Pfam-B_20685 (release 10.0). This domain is found at the C-terminus of the mycothiol maleylpyruvate isomerase enzyme (MDMPI). The structure of this protein has been solved  . This domain appears weakly similar to Pfam:PF08608.. 
+PF07399 Protein of unknown function (DUF1504)<br>Pfam-B_20945 (release 10.0). This family consists of several hypothetical bacterial proteins of around 440 residues in length. The function of this family is unknown.. 
+PF07400 Interleukin 11<br>Pfam-B_20854 (release 10.0). This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11  . Family members seem to be restricted to mammals.. 
+PF07401 Bovine Lentivirus VIF protein<br>Pfam-B_21067 (release 10.0). This family consists of several Lentivirus viral infectivity factor (VIF) proteins. VIF is known to be essential for ability of cell-free virus preparation to infect cells  . Members of this family are specific to  Bovine immunodeficiency virus (BIV) and Jembrana disease virus which also infects cattle.. 
+PF07402 Human herpesvirus U26 protein<br>Pfam-B_21150 (release 10.0). This family consists of several Human herpesvirus U26 proteins of around 300 residues in length. The function of this family is unknown.. 
+PF07403 Protein of unknown function (DUF1505)<br>Pfam-B_21179 (release 10.0). This family consists of several uncharacterised Caenorhabditis elegans proteins of around 115 resides in length. Members of this family contain 6 highly conserved cysteine residues. The function of this family is unknown.. 
+PF07404 Telomere-binding protein beta subunit (TEBP beta)<br>Pfam-B_20928 (release 10.0). This family consists of several telomere-binding protein beta subunits which appear to be specific to the family Oxytrichidae. Telomeres are specialised protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. TEBP beta forms a complex with TEBP alpha and this complex is able to recognise and bind ssDNA to form a sequence-specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes  . . 
+PF07405 Protein of unknown function (DUF1506)<br>Pfam-B_20962 (release 10.0). This family consists of several bacterial proteins of around 130 residues in length. Members of this family seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.. 
+PF07406 NICE-3 protein<br>Pfam-B_21003 (release 10.0). This family consists of several eukaryotic NICE-3 and related proteins. The gene coding for NICE-3 is part of the epidermal differentiation complex (EDC) which comprises a large number of genes that are of crucial importance for the maturation of the human epidermis  . The function of NICE-3 is unknown.. 
+PF07407 Seadornavirus VP6 protein<br>Pfam-B_21021 (release 10.0). This family consists of several VP6 proteins from the Banna virus as well as a related protein VP5 from the Kadipiro virus. Members of this family are typically of around 420 residues in length. The function of this family is unknown.. 
+PF07408 Protein of unknown function (DUF1507)<br>Pfam-B_21047 (release 10.0). This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.. 
+PF07409 Phage protein GP46<br>Pfam-B_20855 (release 10.0). This family contains GP46 phage proteins (approximately 120 residues long).. 
+PF07410 Streptococcus thermophilus bacteriophage Gp111 protein<br>Pfam-B_20904 (release 10.0). This family consists of several Streptococcus thermophilus bacteriophage Gp111 proteins of around 110 residues in length. The function of this family is unknown.. 
+PF07411 Domain of unknown function (DUF1508)<br>Pfam-B_20853 (release 10.0). This family represents a series of bacterial domains of unknown function of around 50 residues in length. Members of this family are often found as tandem repeats and in some cases represent the whole protein. All member proteins are described as being hypothetical.. 
+PF07412 Geminin<br>Pfam-B_20861 (release 10.0). This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle  .. 
+PF07413 Herpes_UL37; <br>Betaherpesvirus immediate-early glycoprotein UL37. Pfam-B_21151 (release 10.0). This family consists of several Betaherpesvirus immediate-early glycoprotein UL37 sequences. The human cytomegalovirus (HCMV) UL37 immediate-early regulatory protein is a type I integral membrane N-glycoprotein which traffics through the ER and the Golgi network  .. 
+PF07415 Gammaherpesvirus latent membrane protein (LMP2) protein<br>Pfam-B_21212 (release 10.0). This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus is a human Gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. The significance of LMP2B and its role in pathogenesis remain unclear  .. 
+PF07416 Crinivirus P26 protein<br>Pfam-B_21324 (release 10.0). This family consists of several Crinivirus P26 proteins which seem to be found exclusively in the Lettuce infectious yellows virus. The function of this family is unknown.. 
+PF07417 Transcriptional regulator Crl<br>Pfam-B_20900 (release 10.0). This family contains the bacterial transcriptional regulator Crl (approximately 130 residues long). This is a transcriptional regulator of the csgA curlin subunit gene for curli fibres that are found on the surface of certain bacteria  .. 
+PF07418 Acidic phosphoprotein precursor PCEMA1<br>Pfam-B_20971 (release 10.0). This family consists of several acidic phosphoprotein precursor PCEMA1 sequences which appear to be found exclusively in Plasmodium chabaudi. PCEMA1 is an antigen that is associated with the membrane of the infected erythrocyte throughout the entire intraerythrocytic cycle  . The exact function of this family is unclear. . 
+PF07419 PilM<br>Pfam-B_20906 (release 10.0). This family contains the bacterial protein PilM (approximately 150 residues long). PilM is an inner membrane protein that has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body  .. 
+PF07420 Protein of unknown function (DUF1509)<br>Pfam-B_21379 (release 10.0). This family consists of several uncharacterised viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.. 
+PF07421 Neurotensin/neuromedin N precursor<br>Pfam-B_20947 (release 10.0). This family contains the precursor of bacterial neurotensin/neuromedin N (approximately 170 residues long). This the common precursor of two biologically active related peptides, neurotensin and neuromedin N. It undergoes tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the neurotensin or neuromedin N sequence  .. 
+PF07422 Sexual stage antigen s48/45 domain<br>Pfam-B_21037 (release 10.0) and Pfam-B_4621 (release 14.0). This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation  . This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.. 
+PF07423 Protein of unknown function (DUF1510)<br>Pfam-B_21355 (release 10.0). This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown.. 
+PF07424 TrbM<br>Pfam-B_21098 (release 10.0). This family contains the bacterial protein TrbM (approximately 180 residues long). In Comamonas testosteroni T-2, TrbM is derived from the IncP1beta plasmid pTSA, which encodes the widespread genes for p-toluenesulfonate (TSA) degradation  .. 
+PF07425 Pardaxin<br>Pfam-B_21422 (release 10.0). This family consists of several Pardaxin proteins. Pardaxin, a 33-amino-acid pore-forming polypeptide toxin isolated from the Red Sea Moses sole Pardachirus marmoratus, has a helix-hinge-helix structure. This is a common structural motif found both in antibacterial peptides that can act selectively on bacterial membranes (e.g., cecropin), and in cytotoxic peptides that can lyse both mammalian and bacterial cells (e.g., melittin). Pardaxin possesses a high antibacterial activity with a significantly reduced haemolytic activity towards human red blood cells compared with melittin  . Pardaxin has also been found to have a shark repellent action  .. 
+PF07426 Dynactin subunit p22<br>Pfam-B_21336 (release 10.0). This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localises to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis  . Family members are approximately 170 residues long.. 
+PF07428 15-O-acetyltransferase Tri3<br>Pfam-B_21449 (release 10.0). This family represents a conserved region approximately 400 residues long within 15-O-acetyltransferase (Tri3), which seems to be restricted to ascomycete fungi. In Fusarium sporotrichioides, this is required for acetylation of the C-15 hydroxyl group of trichothecenes in the biosynthesis of T-2 toxin  .. 
+PF07429 Fuc4NAc_transf;<br>4-alpha-L-fucosyltransferase glycosyl transferase group 56. Pfam-B_21451 (release 10.0). This family contains the bacterial enzyme 4-alpha-L-fucosyltransferase (Fuc4NAc transferase) (EC 2.4.1.-) (approximately 360 residues long). This catalyses the synthesis of Fuc4NAc-ManNAcA-GlcNAc-PP-Und (lipid III) as part of the biosynthetic pathway of enterobacterial common antigen (ECA), a polysaccharide comprised of the trisaccharide repeat unit Fuc4NAc-ManNAcA-GlcNAc  .. 
+PF07430 Phloem filament protein PP1<br>Pfam-B_20843 (release 10.0). This family represents a conserved region approximately 200 residues long, four copies of which are found within the plant phloem filament protein PP1. This is one of the constituents of the proteinaceous filaments found in the sieve elements of Cucurbita phloem  .. 
+PF07431 Protein of unknown function (DUF1512)<br>Pfam-B_21354 (release 10.0). This family consists of several archaeal proteins of around 370 residues in length. The function of this family is unknown.. 
+PF07432 Histone H1-like protein Hc1<br>Pfam-B_21362 (release 10.0). This family consists of several bacterial histone H1-like Hc1 proteins. In Chlamydia, Hc1 is expressed in the late stages of the life cycle, concomitant with the reorganisation of chlamydial reticulate bodies into elementary bodies. This suggests that Hc1 protein plays a role in the condensation of chromatin during intracellular differentiation  .. 
+PF07433 Protein of unknown function (DUF1513)<br>Pfam-B_21436 (release 10.0). This family consists of several bacterial proteins of around 360 residues in length. The function of this family is unknown.. 
+PF07434 CblD like pilus biogenesis initiator<br>Pfam-B_21452 (release 10.0). This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis  . The family also contains a variety of Enterobacterial minor pilin proteins.. 
+PF07435 YycH protein<br>Vella Briffa B, Szurmant H, Mistry J. Pfam-B_21457 (release 10.0). This family contains the bacterial protein YycH which is approximately 450 residues long. YycH plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG.  YycG forms a two component system together with its cognate response regulator YycF. PhoA fusion studies have shown that YycH is transported across the cytoplasmic protein. It is postulated that YycH functions as an antagonist to YycG  . The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions  .. 
+PF07436 Curtovirus V3 protein<br>Pfam-B_21777 (release 10.0). This family consists of several Curtovirus V3 proteins of around 90 residues in length. The function of this family is unknown.. 
+PF07437 YfaZ_precursor; <br>Pfam-B_21552 (release 10.0). This family contains the precursor of the bacterial protein YfaZ  (approximately 180 residues long). Many members of this family are hypothetical proteins.. 
+PF07438 Protein of unknown function (DUF1514)<br>Moxon SJ, Eberhardt R. Pfam-B_21857 (release 10.0). This family consists of several Staphylococcus aureus and related bacteriophage proteins of around 65 residues in length. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF07439 Protein of unknown function (DUF1515)<br>Pfam-B_21875 (release 10.0). This family consists of several hypothetical bacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Rhizobium species. The function of this family is unknown.. 
+PF07440 Caerin 1 protein<br>Pfam-B_22039 (release 10.0). This family consists of several caerin 1 proteins from Litoria species. The caerin 1 peptides are among the most powerful of the broad-spectrum antibiotic amphibian peptides  .. 
+PF07441 SigmaK-factor processing regulatory protein BofA<br>Pfam-B_21773 (release 10.0). This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein  .. 
+PF07442 Ponericin<br>Pfam-B_21790 (release 10.0). This family contains a number of ponericin peptides (approximately 30 residues long) from the venom of the predatory ant Pachycondyla goeldii. These peptides exhibit antibacterial and insecticidal properties, and may adopt an amphipathic alpha-helical structure in polar environments such as cell membranes  .. 
+PF07444 Ycf66 protein N-terminus<br>Pfam-B_21840 (release 10.0). This family represents the N-terminus (approximately 80 residues) of Ycf66, a protein that seems to be restricted to eukaryotes that contain chloroplasts and to cyanobacteria.. 
+PF07445 Primosomal replication protein priB and priC<br>Pfam-B_22037 (release 10.0). This family contains the bacterial primosomal replication proteins priB and priC (approximately 180 residues long). In Escherichia coli, these function in the assembly of the primosome  .. 
+PF07447 Matrix protein VP40<br>Pfam-B_22295 (release 10.0). This family contains viral VP40 matrix proteins that seem to be restricted to the Filoviridae. These play an important role in the assembly process of virus particles by interacting with cellular factors, cellular membranes, and the ribonuclearprotein particle complex. It has been shown that the N-terminal region of VP40 folds into a mixture of hexameric and octameric states - these may have distinct roles  .. 
+PF07448 Secreted phosphoprotein 24 (Spp-24)<br>Pfam-B_22318 (release 10.0). This family represents a conserved region approximately 140 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover  .. 
+PF07449 Hydrogenase-1 expression protein HyaE<br>Pfam-B_21851 (release 10.0). This family contains bacterial hydrogenase-1 expression proteins approximately 120 residues long. This includes the E. coli protein HyaE, and the homologous proteins HoxO of R. eutropha and HupG of R. leguminosarum. Deletion of the hoxO gene in R. eutropha led to complete loss of the uptake [NiFe] hydrogenase activity, suggesting that it has a critical role in hydrogenase assembly  .. 
+PF07450 Formate hydrogenlyase maturation protein HycH<br>Pfam-B_22086 (release 10.0). This family contains the bacterial formate hydrogenlyase maturation protein HycH, which is approximately 140 residues long. This may be required for the conversion of a precursor form of the large subunit of hydrogenlyase 3 into a mature form  .. 
+PF07451 Stage V sporulation protein AD (SpoVAD)<br>Pfam-B_22130 (release 10.0). This family contains the bacterial stage V sporulation protein AD (SpoVAD), which is approximately 340 residues long. This is one of six proteins encoded by the spoVA operon, which is transcribed exclusively in the forespore at about the time of dipicolinic acid (DPA) synthesis in the mother cell. The functions of the proteins encoded by the spoVA operon are unknown, but it has been suggested they are involved in DPA transport during sporulation  .. 
+PF07452 CHRD domain<br>CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins.  This family includes bacterial homologues. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin (Swiss:Q9H2X0) and Drosophila SOG (Swiss:Q24025).  .. 
+PF07453 NUMOD1 domain<br>
+PF07454 Stage II sporulation protein P (SpoIIP)<br>Pfam-B_21650 (release 10.0). This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation  . Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex  . SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity  .. 
+PF07455 Phage polarity suppression protein (Psu)<br>Pfam-B_21666 (release 10.0). This family contains a number of phage polarity suppression proteins (Psu) (approximately 190 residues long). The Psu protein of bacteriophage P4 causes suppression of transcriptional polarity in Escherichia coli by overcoming Rho termination factor activity  .. 
+PF07456 Heptaprenyl diphosphate synthase component I<br>Pfam-B_22032 (release 10.0). This family contains component I of bacterial heptaprenyl diphosphate synthase (EC:2.5.1.30) (approximately 170 residues long). This is one of the two dissociable subunits that form the enzyme, both of which are required for the catalysis of the biosynthesis of the side chain of menaquinone-7  .. 
+PF07457 Protein of unknown function (DUF1516)<br>Pfam-B_22136 (release 10.0). This family contains a number of hypothetical bacterial proteins of unknown function approximately 120 residues long.. 
+PF07458 Sperm protein associated with nucleus, mapped to X chromosome<br>Pfam-B_22197 (release 10.0). This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic  .. 
+PF07459 CTX phage RstB protein<br>Pfam-B_22203 (release 10.0). This family contains a number of RstB proteins approximately 120 residues long, including RstB1 and RstB2, from the Vibrio cholerae phage CTX. Functional analyses indicate that rstB2 is required for integration of the CTXphi phage into the V. cholerae chromosome  .. 
+PF07460 NUMOD3 motif (2 copies)<br>NUMOD3 is a DNA-binding motif found in homing endonucleases and related proteins. It occurs on its own or in tandem repeats in GIY-YIG (Pfam:PF01541) and HTH proteins. It constitutes a beta-turn-loop-helix subregion of the the DNA-binding domain of I-TevI homing endonuclease (Swiss:P13299)  .. 
+PF07461 Nicotine adenine dinucleotide glycohydrolase (NADase)<br>Pfam-B_21586 (release 10.0). This family consists of several bacterial nicotine adenine dinucleotide glycohydrolase (NGA) proteins which appear to be specific to Streptococcus pyogenes. NAD glycohydrolase (NADase) is a potential virulence factor. Streptococcal NADase may contribute to virulence by its ability to cleave beta-NAD at the ribose-nicotinamide bond, depleting intracellular NAD pools and producing the potent vasoactive compound nicotinamide  .. 
+PF07462 Merozoite surface protein 1 (MSP1) C-terminus<br>Pfam-B_21542 (release 10.0). This family represents the C-terminal region of merozoite surface protein 1 (MSP1) which are found in a number of Plasmodium species. MSP-1 is a 200-kDa protein expressed on the surface of the P. vivax merozoite. MSP-1 of Plasmodium species is synthesised as a high-molecular-weight precursor and then processed into several fragments. At the time of red cell invasion by the merozoite, only the 19-kDa C-terminal fragment (MSP-119), which contains two epidermal growth factor-like domains, remains on the surface. Antibodies against MSP-119 inhibit merozoite entry into red cells, and immunisation with MSP-119 protects monkeys from challenging infections. Hence, MSP-119 is considered a promising vaccine candidate  .. 
+PF07463 NUMOD4 motif<br>NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related proteins  .. 
+PF07464 Apolipophorin-III precursor (apoLp-III)<br>Pfam-B_31170 (release 10.0). This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage  .. 
+PF07465 Photosystem I protein M (PsaM)<br>Pfam-B_21548 (release 10.0). This family consists of several plant and cyanobacterial photosystem I protein M (PsaM) sequences. PsaM forms part of the photosystem I complex and its binding is stabilised by PsaI  .. 
+PF07466 Protein of unknown function (DUF1517)<br>Pfam-B_22018 (release 10.0). This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.. 
+PF07467 Beta-lactamase inhibitor (BLIP)<br>Pfam-B_41444 (release 10.0). The structure of BLIP reveals two structural domains, which form a polar, concave surface that docks onto a predominantly polar, convex protrusion on beta-lactamase. The ability of BLIP to adapt to a variety of class A beta-lactamases is thought to be due to flexibility between these two domains  .. 
+PF07468 Agglutinin<br>Pfam-B_57133 (release 10.0). 
+PF07469 Domain of unknown function (DUF1518) <br>Pfam-B_1525 (release 10.0). This domain, which is usually found tandemly repeated, is found various receptor co-activating proteins.. 
+PF07470 Glycosyl Hydrolase Family 88<br>Pfam-B_10896 (release 10.0). Unsaturated glucuronyl hydrolase catalyses the hydrolytic release of  unsaturated glucuronic acids from oligosaccharides (EC:3.2.1.-) produced by the reactions of polysaccharide lyases  . . 
+PF07471 Phage DNA packaging protein Nu1<br>Pfam-B_11430 (release 10.0). Terminase, the DNA packaging enzyme of bacteriophage lambda, is a  heteromultimer composed of subunits Nu1 and A.  The smaller  Nu1 terminase subunit has  a low-affinity ATPase stimulated by non-specific DNA  . . 
+PF07472 Fucose-binding lectin II (PA-IIL)<br>Pfam-B_17609 (release 10.0). In Pseudomonas aeruginosa the fucose-binding lectin II (PA-IIL) contributes to the pathogenic virulence of the bacterium. PA-IIL functions as a tetramer when binding fucose. Each monomer is comprised of a nine-stranded, antiparallel beta-sandwich arrangement and contains two calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions  .. 
+PF07473 Spasmodic peptide gm9a<br>Pfam-B_90829 (release 10.0). This family consists of several spasmodic peptide gm9a sequences. Conotoxin gm9a is a putative 27-residue polypeptide encoded by Conus gloriamaris and is known to be a homologue of the "spasmodic peptide", tx9a, isolated from the venom of the mollusk-hunting cone shell Conus textile  . Upon injection of this venom component, normal mice are converted into behavioural phenocopies of a well-known mutant, the spasmodic mouse  .. 
+PF07474 G2F domain<br>Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein Pfam:PF01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.. 
+PF07475 HPr Serine kinase C-terminal domain<br>This family represents the C terminal kinase domain of Hpr Serine/threonine kinase PtsK.  This kinase is  the sensor in a multicomponent phosphorelay system in control of carbon  catabolic repression in bacteria  .  This kinase in unusual in that it  recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating  enzymes  . X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller  .. 
+PF07476 Methylaspartate ammonia-lyase C-terminus<br>Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the C-terminal region of Methylaspartate ammonia-lyase and contains a TIM barrel fold similar to the Pfam:PF01188. This family represents the catalytic domain and contains a metal binding site  .. 
+PF07477 Glycosyl hydrolase family 67 C-terminus<br>Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the C terminal region of alpha-glucuronidase which is mainly alpha-helical. It wraps around the catalytic domain (Pfam:PF07488), making additional interactions both with the N-terminal domain (Pfam:PF03648) of its parent monomer and also forming the majority of the dimer-surface with the equivalent C-terminal domain of the other monomer of the dimer  .. 
+PF07478 D-ala D-ala ligase C-terminus<br>This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF)  .. 
+PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus<br>NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain  .. 
+PF07481 Domain of Unknown Function (DUF1521)<br>This family of unknown function is found in a limited  set of Bradyrhizobium proteins. There appears to be a periodic -DG- motif in it.. 
+PF07482 Domain of Unknown Function (DUF1522)<br>
+PF07483 Tryptophan-rich Synechocystis species C-terminal domain<br>This domain is found at the C-terminus, normally between 2-3 copies, of a range of Synechocystis membrane proteins. This domain is fairly tryptophan rich as well. . 
+PF07484 Phage Tail Collar Domain<br>This region is occasionally found in conjunction with Pfam:PF03335. Most of the family appear to be phage tail proteins; however some appear to be involved in other processes. For instance Swiss:Q03314 from Rhizobium leguminosarum may be involved in plant-microbe interactions ( ). A related protein Swiss:Q9L3N1 is involved in the pathogenicity of Microcystis aeruginosa. The finding of this family in a structural component of the phage tail fibre baseplate (Swiss:P10930) suggests that its function is structural rather than enzymatic. Structural studies show this region consists of a helix and a loop ( ) and three beta-strands. This alignment does not catch the third strand as it is separated from the rest of the structure by around 100 residues. This strand is conserved in homologues but the intervening sequence is not. Much of the function of Swiss:P10930 appears to reside in this intervening region. In the tertiary structure of the phage baseplate this domain forms part of the 'collar'. The domain may bind SO4, however the residues accredited with this vary between the PDB file and the Swiss-Prot entry. The long unconserved region maybe due to domain swapping in and out of a loop or reflective of rapid evolution. . 
+PF07485 DUF1259; <br>Domain of Unknown Function (DUF1259). This family is the lppY/lpqO homologue family.. 
+PF07486 Cell Wall Hydrolase<br>These enzymes have been implicated in cell wall hydrolysis, most extensively in Bacillus subtilis. For instance Swiss:P50739 is expressed during sporulation as an inactive form and then deposited on the cell outer cortex. During germination the the enzyme is activated and hydrolyses the cortex( ). A similar role is carried out by the partially redundant Swiss:P42249 ( ). It is not clear  whether these enzymes are amidases or peptidases.. 
+PF07487 SopE GEF domain<br>Pfam-B_18665 (release 7.8). This family represents the C-terminal guanine nucleotide exchange factor (GEF) domain of SopE. Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, can activate Cdc42, an essential component of the host cellular signaling cascade, in a Dbl-like fashion despite its lack of sequence similarity to Dbl-like proteins, the Rho-specific eukaryotic guanine nucleotide exchange factors  .. 
+PF07488 Glycosyl hydrolase family 67 middle domain<br>Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans.  This family represents the central catalytic domain of alpha-glucuronidase  .. 
+PF07489 Translocated intimin receptor (Tir) C-terminus<br>Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation  . This family represents the Tir C-terminal domain  which has been reported to bind uninfected host cells and beta-1 integrins although the role of intimin binding to integrins is unclear. This intimin C-terminal domain has also been shown to be sufficient for Tir recognition  .. 
+PF07490 Translocated intimin receptor (Tir) N-terminus<br>Griffiths-Jones SR, Moxon SJ. Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation  . This family represents the Tir N-terminal domain  which is involved in Tir stability and Tir secretion  .. 
+PF07491 Protein phosphatase inhibitor  <br>Pfam-B_11090 (release 10.0). These proteins include Ypi1,  (Swiss:P43587), a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor   and ppp1r11/hcgv (Swiss:O60927), annotated as having protein phosphatase inhibitor activity [2-3].. 
+PF07492 Neutral trehalase Ca2+ binding domain<br>Neutral trehalases mobilise trehalose accumulated by fungal cells as a protective and storage carbohydrate. This family represents a calcium-binding domain similar to EF hand. Residues 97 and 108 in Swiss:O42893 have been implicated in this interaction. It is thought that this domain may provide a general mechanism for regulating neutral trehalase activity in yeasts and filamentous fungi  .. 
+PF07494 Two component regulator propeller<br>A large group of two component regulator proteins appear to have the same N-terminal structure of  14 tandem repeats. These repeats show homology to Pfam:PF01011 and Pfam:PF00400 indicating that they are likely to form a beta-propeller. This family has been built with artificially high cut-offs in order to avoid overlaps with other beta-propeller  families. The fourteen repeats are likely to form two propellers; it is not clear if these structures are likely to recruit other proteins or interact with DNA.. 
+PF07495 Y_Y_Y domain<br>This domain is mostly found at the end of the beta propellers (Pfam:PF07494) in a family of two component regulators. However they are also found tandemly repeated in Swiss:Q891H4 without other signal conduction domains being present. It's named after the conserved tyrosines found in the alignment. The exact function is not known.. 
+PF07496 CW-type Zinc Finger<br>This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by  , and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including ...chromatin methylation status and early embryonic development." Weak homology to Pfam:PF00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found  .. 
+PF07497 Rho termination factor, RNA-binding domain<br>Pfam-B_1610 (release 11.0). The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers  .. 
+PF07498 Rho termination factor, N-terminal domain<br>Pfam-B_1610 (release 11.0). The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers  . This domain is found to the N-terminus of the RNA binding domain (Pfam:PF07497).. 
+PF07499 RuvA, C-terminal domain<br>Pfam-B_1373 (release 11.0). Homologous recombination is a crucial process  in all living organisms.  In bacteria, this process the RuvA, RuvB, and RuvC proteins are involved. More specifically the proteins process the Holliday junction DNA. RuvA is comprised of three distinct domains. The domain represents the C-terminal domain and plays a significant role in the ATP-dependent branch migration of the hetero-duplex  through direct contact with RuvB  . Within the Holliday junction, the C-terminal domain  makes no interaction with DNA  .. 
+PF07500 Transcription factor S-II (TFIIS), central domain<br>Pfam-B_1373 (release 11.0). Transcription elongation by RNA polymerase II is regulated by  the general elongation factor TFIIS. This factor stimulates  RNA polymerase II to transcribe through regions of DNA that  promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III.  The two C-terminal  domains (II and III), this domain and Pfam:PF01096  are required for transcription activity  .. 
+PF07501 G5 domain<br>This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies.  It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA.  The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.. 
+PF07502 MANSC; <br>This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins  .  Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors  .. 
+PF07503 HypF finger<br>The HypF family of proteins are involved in the maturation and  regulation of hydrogenase ( ). In the N-terminus they appear to have two Zinc finger domains, as modelled by this family.. 
+PF07504 Fungalysin/Thermolysin Propeptide Motif<br>This motif is found in both the bacterial M4 peptidase propeptide and the fungal M36 propeptide. Its exact function is not clear, but it is likely to either  inhibit the peptidase, so as to prevent its premature activation, or has a chaperone activity. Both of these roles have been ascribed to the M4 and M36 propeptides ( ,  ).. 
+PF07505 Phage protein Gp37/Gp68<br>Homologues of phage proteins Gp37 and Gp68 are found in several bacteria.. 
+PF07506 ParB; <br>RepB plasmid partitioning protein. This family includes proteins with sequence similarity to the RepB partitioning protein of the large Ti (tumour-inducing) plasmids of Agrobacterium tumefaciens[1-2].. 
+PF07507 WavE lipopolysaccharide synthesis<br>These proteins are encoded by putative wav gene  clusters, which are responsible for the synthesis of the core oligosaccharide (OS) region of  Vibrio cholerae lipopolysaccharide  . . 
+PF07508 Recombinase<br>This domain is usually found associated with Pfam:PF00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.. 
+PF07509 Protein of unknown function (DUF1523)<br>
+PF07510 Protein of unknown function (DUF1524)<br>COGs (COG3472) & PSI2 target BIG_246. This family of uncharacterised proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.. 
+PF07511 Protein of unknown function (DUF1525)<br>
+PF07514 Putative helicase<br>Some members of this family have been annotated as helicases.. 
+PF07515 Protein of unknown function (DUF1528)<br>
+PF07516 SecA Wing and Scaffold domain<br>SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane.  SecA protein achieves this translocation, in association with SecY protein, in an ATP  dependent manner.  This family is composed of two C-terminal alpha helical subdomains: the wing and scaffold subdomains  .. 
+PF07517 SecA DEAD-like domain<br>SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner [1,2].  This domain represents the N-terminal ATP-dependent helicase domain, which is related to the Pfam:PF00270  .. 
+PF07519 Tannase and feruloyl esterase<br>This family includes fungal tannase   and feruloyl esterase [2-3]. It also includes several bacterial homologues of unknown function.. 
+PF07520 Virulence factor SrfB<br>This family includes homologues of  SsrAB is a two-component regulatory system encoded within the Salmonella pathogenicity island SPI-2.  Among the products of genes activated by SsrAB within epithelial and macrophage cells is Swiss:Q9KIJ9  . Homologues are found in several other proteobacteria.. 
+PF07521 RNA-metabolising metallo-beta-lactamase<br>Pfam-B_760 (release 11.0). The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases.  The fifth motif appears to be specific to function.\.     This entry represents the fifth motif from metallo-beta-lactamases involved in RNA metabolism  .. 
+PF07522 DNA repair metallo-beta-lactamase<br>The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases.  The fifth motif appears to be specific to function.\.     This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair  .. 
+PF07523 Bacterial Ig-like domain (group 3)<br>This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.. 
+PF07524 Bromodomain associated<br>This domain is predicted to bind DNA   and is often found associated with Pfam:PF00439 and in transcription factors. It has a histone-like fold.. 
+PF07525 Clip; SOCS_Clip; <br>The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.. 
+PF07526 Associated with HOX<br>The function of this domain is unknown  . It is often found in plant proteins associated with Pfam:PF00046.. 
+PF07527 Hairy Orange<br>The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split [1,2].  The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute .. 
+PF07528 DZF domain<br>The function of this domain is unknown  . It is often found associated with Pfam:PF00098 or Pfam:PF00035. This domain has been predicted to belong to the nucleotidyltransferase superfamily  .. 
+PF07529 HSA<br>This domain is predicted to bind DNA   and is often found associated with helicases.. 
+PF07530 Associated with zinc fingers<br>This function of this domain is unknown   and is often found associated with Pfam:PF00096.. 
+PF07531 NHR1 homology to TAF<br>This corresponds to the region NHR1 that is  conserved between the product of the nervy gene in Drosophila and the human mtg8b protein  , which is hypothesised to be a transcription factor.  . 
+PF07532 Bacterial Ig-like domain (group 4)<br>This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.. 
+PF07533 TCH; <br>The function of this domain is unknown  . It is often found associated with helicases and transcription factors.. 
+PF07534 TLD<br>This domain is predicted to be an enzyme   and is often found associated with Pfam:PF01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices  .. 
+PF07535 DBF zinc finger<br>This domain is predicted to bind metal ions   and is often found associated with Pfam:PF00533 and Pfam:PF02178. It was first identified in the Drosophila chiffon gene product  , and is associated with initiation of DNA replication.. 
+PF07536 HWE histidine kinase<br>Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria.  The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as Pfam:PF00512  .  The family was defined by   the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to Pfam:PF02518. These proteins are found in a variety of alpha- and gamma-proteobacteria, with significant enrichment in the rhizobia.. 
+PF07537 CamS sex pheromone cAM373 precursor<br>Pfam-B_18913 (release 11.0). This family includes CamS (Swiss:Q8L313), from which Staphylococcus aureus sex pheromone staph-cAM373 is processed.. 
+PF07538 Clostridial hydrophobic W<br>A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats  . ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.. 
+PF07539 Down-regulated in metastasis<br>Pfam-B_10642 (release 11.0). These eukaryotic proteins include DRIM  (Down-Regulated In Metastasis) (Swiss:O75691), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells  .  It is believed to be involved in processing of non-coding RNA  .. 
+PF07540 Nucleolar complex-associated protein<br>Pfam-B_8562 (release 11.0). Nucleolar complex-associated protein (Noc3p, Swiss:Q07896) is conserved in eukaryotes and has essential roles in replication and rRNA processing in Saccharomyces cerevisiae  .. 
+PF07541 Eukaryotic translation initiation factor 2 alpha subunit<br>Pfam-B_5125 (release 11.0). These proteins share a region of similarity that falls towards the C terminus from Pfam:PF00575.. 
+PF07542 ATP12 chaperone protein<br>Pfam-B_6737 (release 11.0). Mitochondrial F1-ATPase is an oligomeric enzyme composed of five distinct subunit polypeptides. The alpha and beta subunits make up the bulk of protein mass of F1. In Saccharomyces cerevisiae both subunits are synthesised as precursors with amino-terminal targeting signals that are removed upon translocation of the proteins to the matrix compartment  .  These proteins include examples from eukaryotes and bacteria and may have chaperone activity, being involved in F1 ATPase complex assembly.. 
+PF07543 DUF1531; <br>Protein trafficking PGA2. Pfam-B_46790 (release 11.0). A Saccharomyces cerevisiae member of this family (PGA2) is an ER protein which has been implicated in protein trafficking  .. 
+PF07544 CSE2; <br>RNA polymerase II transcription mediator complex subunit 9. Pfam-B_45625 (release 11.0). This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator  . Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter  .. 
+PF07545 Vestigial/Tondu family<br>The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd  .. 
+PF07546 EMI domain<br>The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al  . This is to stop the family overlapping with other domains.. 
+PF07547 RSD-2 N-terminal domain<br>This domain is found in three copies in the N-terminus of the C. elegans RSD-2 protein. RSD-2 (RNAi spreading defective) is involved in systemic RNAi  .  Mutations in the rsd-2 gene do not effect somatic genes but only germline expressed genes  .. 
+PF07548 Chlamydia polymorphic membrane protein middle domain<br>This family contains several Chlamydia polymorphic membrane proteins.  Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract.  This domain is found between the beta-helical repeats (Pfam:PF02415) and the C-terminal Pfam:PF03797. This domain is excised subsequent to secretion  .. 
+PF07549 SecD/SecF GG Motif<br>This family consists of various prokaryotic SecD and SecF protein export membrane proteins.\.    This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC  . SecD and SecF are required to maintain a proton motive force  . This alignment encompasses a -GG- motif typically found in N-terminal half of the SecD/SecF proteins .. 
+PF07550 Protein of unknown function (DUF1533)<br>This family consists of several hypothetical bacterial proteins and is around 60 residues in length. It's function is not known.. 
+PF07551 Protein of unknown function (DUF1534)<br>This family is found in a group of small bacterial proteins. Its function is not known.. 
+PF07552 Spore Coat Protein X and V domain<br>This family is found in the Bacilliales coat protein X as a tandem repeat and also in coat protein V. The proteins are found in the insoluble fraction  .. 
+PF07553 DUF1535; <br>Host cell surface-exposed lipoprotein. This is a family of lipoproteins that is involved in superinfection exclusion.  Proteins in this family have been shown to act at the stage of DNA release from the phage head into the cell  .. 
+PF07554 Uncharacterised Sugar-binding Domain<br>This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by  . Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as Pfam:PF05089 further supports this proposal. It is found in the  C-terminal part of Swiss:O82833, which is removed during maturation  ( ). Some of the proteins it is found in (e.g. Swiss:Q9RL69) are  involved in methicillin resistance ( ). The name FIVAR derives from Found In Various Architectures. . 
+PF07555 Hyaluronidase_2; <br>beta-N-acetylglucosaminidase . Pfam-B_4394 (release 12.0). This family has previously been described as a hyaluronidase [1,2]. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity  .. 
+PF07556 Protein of unknown function (DUF1538)<br>This family contains several conserved glycines and phenylalanines.. 
+PF07557 Shugoshin C terminus<br>Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered  . Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres  .. 
+PF07558 Shugoshin N-terminal coiled-coil region<br>The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C Pfam:PF07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore  . Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly  . Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process  .. 
+PF07559 Flagellar basal body protein FlaE<br>This family consists of several bacterial FlaE flagellar proteins. These  proteins are part of the flageller basal body rod complex.. 
+PF07560 Domain of Unknown Function (DUF1539)<br>
+PF07561 Domain of Unknown Function (DUF1540)<br>This family has four conserved cysteines, which is suggestive of a metal binding function.. 
+PF07562 ANF_assoc; <br>Nine Cysteines Domain of family 3 GPCR. This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the Pfam:PF00003 in several receptor proteins.. 
+PF07563 Protein of unknown function (DUF1541)<br>This family consists of several hypothetical bacterial and occurs as a tandem repeat.. 
+PF07564 Domain of Unknown Function (DUF1542)<br>This domain is found in several cell surface proteins. Some are involved in antibiotic resistance (e.g Swiss:Q9RL69 and Swiss:Q9LCJ9)   and/or cellular adhesion (e.g. Swiss:Q931R6)  .. 
+PF07565 Band 3 cytoplasmic domain<br>Pfam-B_1004 (release 3.0). This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).  . 
+PF07566 Domain of Unknown Function (DUF1543)<br>This domain is found as 1-2 copies in a small family of proteins of unknown function.. 
+PF07568 Histidine kinase<br>This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea.. 
+PF07569 TUP1-like enhancer of split<br>Pfam-B_7106 (release 12.0). The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain Pfam:PF00400.. 
+PF07571 Protein of unknown function (DUF1546)<br>Pfam-B_3691 (release 12.0). Associated with Pfam:PF02969 in  Transcription initiation factor TFIID subunit 6 (TAF6).. 
+PF07572 Bucentaur or craniofacial development<br>Pfam-B_10149 (release 12.0). Bucentaur or craniofacial development protein 1 (BCNT) in ruminents has a different domain architecture to that in mouse and human. For this reason it has been used as a model for molecular  evolution [1-3]. Both bovine and human BCNTs are phosphorylated by casein kinase II in vitro  .. 
+PF07573 Nitrogen regulatory protein AreA N terminus<br>Pfam-B_11486 (release 11.0). The AreA nitrogen regulatory protein proteins (which are  GATA type transcription factors) share a highly conserved N terminus and Pfam:PF00320 at the C terminus.. 
+PF07574 Nse1 non-SMC component of SMC5-6 complex<br>Pfam-B_24547 (release 11.0). S. cerevisiae Nse1 (Swiss:Q07913) forms part of a complex with SMC5-SMC6 This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism [1,2].  It is conserved in eukaryotes from yeast to human.. 
+PF07575 Nuceloporin_Nup85; Nucelopor_Nup85; <br>Pfam-B_55990 (release 11.0). A family of nucleoporins conserved from yeast to human. THe nuclear pore complex is a large assembly composed of two essential complexes: the heptameric Nup84 complex and the heteromeric Nic96-containing complex.  The Nup84 complex is composed of one copy each of Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. The structure of a complex of Nup85 and Seh1 was solved  . The N-terminus of Nup85 is inserted and forms a three-stranded blade that completes the Seh1 6-bladed beta-propeller in trans. Following its N-terminal insertion blade, Nup85 forms a compact cuboid structure composed of 20 helices, with two distinct modules, referred to as crown and trunk  .. 
+PF07576 BRCA1-associated protein 2<br>Pfam-B_5419 (release 11.0). These proteins include BRCA1-associated protein 2 (BRAP2), which binds nuclear localisation signals (NLSs) in vitro and in yeast two-hybrid screening  . These proteins share a region of sequence similarity at their N terminus.  They also have Pfam:PF02148 at the C terminus.. 
+PF07577 Domain of Unknown Function (DUF1547)<br>This family appears to be found only in a small family of Chlamydia species.. 
+PF07578 Lipid A Biosynthesis N-terminal domain<br>This family is found at the N-terminus of a group of Chlamydial Lipid A biosynthesis proteins. It is also found by itself in a family of proteins of unknown function.. 
+PF07579 Domain of Unknown Function (DUF1548)<br>This family appears to be found only in a small family of Chlamydia proteins.. 
+PF07580 M26 IgA1-specific Metallo-endopeptidase C-terminal region<br>These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with Pfam:PF00746, they may be attached to the cell wall.. 
+PF07581 The GLUG motif<br>This family is found in the IgA1 (M26) peptidases, which attached to the cell wall peptidoglycan by an amide bond ( ). IgA1 protease selectively cleaves human IgA1 and  is likely to be a pathogenicity factor in some pathogens ( ). This family is also found in various other contexts, including with Pfam:PF05860. It is named GLUG after the mostly conserved G-L-any-G motif.. 
+PF07582 AP endonuclease family 2 C terminus<br>This highly-conserved sequence is found at the C terminus of several apurinic/apyrimidinic (AP) endonucleases. in a range of Gram-positive and Gram-negative bacteria. See also Pfam:PF01261.. 
+PF07583 DUF1549; PSC2; <br>Protein of unknown function (DUF1549). Blast single linkage clustering. A family of paralogues in the planctomyces.. 
+PF07584 DUF1550; <br>Aerotolerance regulator N-terminal. Blast clustering of Pirellula proteome. These proteins share a highly-conserved sequence at their N-terminus.  They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains  . BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress  .. 
+PF07585 Protein of unknown function (DUF1551)<br>Blast clustering of Pirellula proteome. A family of proteins identified in Rhodopirellula baltica.. 
+PF07586 DUF1552; <br>Protein of unknown function (DUF1552). Blast clustering of Pirellula proteome. A family of proteins identified in Rhodopirellula baltica.. 
+PF07587 DUF1553; <br>Protein of unknown function (DUF1553). Blast clustering of Pirellula genome. A family of proteins found in Rhodopirellula baltica.. 
+PF07588 Protein of unknown function (DUF1554)<br>Blast clustering of Leptospira proteome. A family of proteins identified in Leptospira interrogans. . 
+PF07589 DUF1555;<br>Blast clustering of Pirellula genome. This motif has been identified in a wide range of bacteria at their C-terminus.  It has been suggested that this is a protein sorting signal. Based on phylogenetic profiling it has been suggested that the EpsH family of proteins mediate this function  .. 
+PF07590 Protein of unknown function (DUF1556)<br>Blast clustering of Pirellula proteome. 
+PF07591 DUF1557;<br>Pretoxin HINT domain. Blast clustering of Leptospira proteome.. A member of the HINT superfamily of proteases that is usually found N-terminal to the toxin module in polymorphic toxin systems. The  domain is predicted to function in releasing the toxin domain by  autoproteolysis  .. 
+PF07592 Transposase_36;<br>Rhodopirellula transposase DDE domain. Blast clustering of Pirellula proteome. These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.. 
+PF07593 ASPIC and UnbV<br>Blast clustering of Pirellula proteome. This conserved sequence is found associated with Pfam:PF00515 in several paralogous proteins in Rhodopirellula baltica.  It is also found associated with Pfam:PF01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC Swiss:Q9NQ78) and in several other bacterial proteins (e.g. Swiss:Q84HN1  ).. 
+PF07595 Planctomycete extracellular<br>Blast clustering of Pirellula proteome. This motif is conserved as the N terminus of several Rhodopirellula baltica proteins predicted to be extracellular.. 
+PF07596 DUF1559; <br>Protein of unknown function (DUF1559). Blast clustering of Pirellula proteome. A large family of paralogous proteins apparently unique to planctomycetes.. 
+PF07597 Protein of unknown function (DUF1560)<br>Blast clustering of Pirellula genome. Small family of short hypothetical proteins in Rhodopirellula baltica.. 
+PF07598 Protein of unknown function (DUF1561)<br>Blast clustering of Leptospira proteome. A family of paralogous proteins in Leptospira interrogans.. 
+PF07599 Protein of unknown function (DUF1563)<br>Blast clustering of Leptospira proteome. A small family of short hypothetical proteins in Leptospira interrogans.. 
+PF07600 Protein of unknown function (DUF1564)<br>Blast clustering of Leptospira proteome. A family of paralogous proteins in Leptospira interrogans. Several (e.g. Swiss:Q8F4V2) have been annotated as possible CopG-like transcriptional regulators (see Pfam:PF01402).. 
+PF07602 Protein of unknown function (DUF1565)<br>Blast clustering of Leptospira proteome. These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterised domains such as Pfam:PF00395 (e.g. Swiss:Q8YWJ6) and Pfam:PF03422 (e.g. Swiss:Q9FBS2).. 
+PF07603 Protein of unknown function (DUF1566)<br>Blast clustering of the Leptospira proteome. These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.. 
+PF07606 Protein of unknown function (DUF1569)<br>Blast clustering of Pirellula proteome. A family of hypothetical proteins identified in Rhodopirellula baltica.. 
+PF07607 Protein of unknown function (DUF1570)<br>Blast clustering of Pirellula proteome. A family of hypothetical proteins in Rhodopirellula baltica. This family carries a highly conserved HExxH sequence motif characteristic of members of the Peptidase clan MA.. 
+PF07608 Protein of unknown function (DUF1571)<br>Blast clustering of Pirellula proteome. A family of paralogous proteins in Rhodopirellula baltica.. 
+PF07609 Protein of unknown function (DUF1572)<br>Blast search with Q7UW06. These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.. 
+PF07610 Protein of unknown function (DUF1573)<br>Blast clustering of Pirellula proteome. These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.. 
+PF07611 Protein of unknown function (DUF1574)<br>A family of hypothetical proteins in Leptospira interrogans.. 
+PF07613 Protein of unknown function (DUF1576)<br>This small family is found in several undescribed proteins. The alignment is distinguished by the frequent occurrence of conserved glycine and aromatic residues.. 
+PF07614 Protein of unknown function (DUF1577)<br>Blast clustering of Leptospira proteome. A family of hypothetical proteins in Leptospira interrogans.. 
+PF07615 YKOF-related Family<br>
+PF07617 Protein of unknown function (DUF1579)<br>Blast clustering of Pirellula proteome. A family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Sinorhizobium meliloti and Agrobacterium tumefaciens.. 
+PF07618 Protein of unknown function (DUF1580)<br>Blast clustering of Pirelllula proteome. A family of short hypothetical proteins found in Rhodopirellula baltica.. 
+PF07619 Protein of unknown function (DUF1581)<br>Blast clustering of Pirellula proteome. Several Rhodopirellula baltica proteins share this probable domain. Most of these proteins are predicted to be secreted or membrane-associated.. 
+PF07620 SLEI<br>Blast clustering of Leptospira proteome. This highly conserved sequence motif is found at the C terminus of several short hypothetical proteins in Leptospira spp and related organisms.. 
+PF07621 Protein of unknown function (DUF1582)<br>Blast clustering of Pirellula proteome. A family of hypothetical proteins in Rhodopirellula baltica.. 
+PF07622 Protein of unknown function (DUF1583)<br>Blast clustering of Pirellula proteome. Most of these Rhodopirellula baltica hypothetical proteins also match Pfam:PF07619.. 
+PF07623 DUF1584; <br>Protein of unknown function (DUF1584). Blast clustering of Pirellula proteome. This sequence motif is highly conserved in several short hypothetical proteins in Rhodopirellula baltica. It also is associated with Pfam:PF07621 in Swiss:Q7UJJ9.. 
+PF07624 DUF1585; <br>Protein of unknown function (DUF1585). Blast clustering of Pirellula proteome . A conserved sequence region at the C terminus of several cytochrome-like proteins in Rhodopirellula baltica.. 
+PF07625 Protein of unknown function (DUF1586)<br>Blast clustering of Pirellula proteome. A family of short hypothetical proteins in Rhodopirellula baltica.. 
+PF07626 DUF1587; <br>Protein of unknown function (DUF1587). Blast clustering of Pirellula proteome. A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07624.. 
+PF07627 DUF1588; PSC1; <br>Protein of unknown function (DUF1588). Blast clustering of Pirellula proteome. A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07626 and Pfam:PF07624.. 
+PF07628 Protein of unknown function (DUF1589)<br>Blast clustering of Pirellula proteome. A family of short hypothetical proteins in Rhodopirellula baltica.. 
+PF07629 Protein of unknown function (DUF1590)<br>Blast clustering of Pirellula proteome. These hypothetical proteins in Rhodopirellula baltica have a conserved C terminal region.. 
+PF07631 DUF1592; <br>Protein of unknown function (DUF1592). Blast clustering of Pirellula proteome. A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07627, Pfam:PF07626, and Pfam:PF07624.. 
+PF07632 Protein of unknown function (DUF1593)<br>Blast clustering of Pirellula proteome. A family of proteins in Rhodopirellula baltica that are predicted to be secreted. Also, a member has been identified in Caulobacter crescentus (Swiss:Q9AAT9). These proteins mat be related to Pfam:PF01156.. 
+PF07634 RtxA repeat<br>This short repeat is found in the RtxA toxin family  .. 
+PF07635 Cytochrom_C_p; PSC3; <br>Planctomycete cytochrome C. Blast clustering of Pirellula proteome. These proteins share a region of homology at their N-terminus that contains the C-{CPWHF}-{CPWR}-C-H-{CFYW} motif typical of cytochromes C, or CxxCH.. 
+PF07636 PSRT<br>Blast clustering of Pirellula proteome. This motif is found at the N terminus of several short hypothetical proteins in Rhodopirellula baltica and the predicted Arylsulfatase B (EC:3.1.6.12) Swiss:Q7UX97.. 
+PF07637 DUF1595; <br>Protein of unknown function (DUF1595). Blast clustering of Pirellula proteome . A family of proteins in Rhodopirellula baltica, associated with Pfam:PF07635, Pfam:PF07626, Pfam:PF07631, Pfam:PF07627, and Pfam:PF07624.. 
+PF07638 ECF sigma factor<br>Blast clustering of Pirellula proteome. These proteins are probably RNA polymerase sigma factors belonging to the extra-cytoplasmic function (ECF) subfamily   and show sequence similarity to Pfam:PF04542 and Pfam:PF04545.. 
+PF07639 YTV<br>Blast clustering of Pirellula proteome. These hypothetical proteins in Rhodopirellula baltica contain several repeats of a sequence whose core is the residues YTV.. 
+PF07640 QPP<br>Blast clustering of Pirellula proteome. These Rhodopirellula baltica proteins share a highly conserved sequence, centred around an invariant QPP motif, at their N termini.  This motif may represent an export signal.. 
+PF07642 Outer membrane protein family (DUF1597)<br>Blast clustering of Pirellula proteome. This family of proteins are likely to be outer membrane beta barrel proteins. Possibly acting as porins.. 
+PF07643 Protein of unknown function (DUF1598)<br>Blast clustering of Pirellula proteome. A family of Rhodopirellula baltica hypothetical proteins of about 500 amino acids in length.. 
+PF07644 Planctomycete PGAMP<br>Blast clustering of Pirellula proteome. This conserved sequence is centred around an invariant motif of PGAMP in several short hypothetical proteins from  the planctomycete Rhodopirellula baltica. The motif also occurs twice in Swiss Q7UVK9.. 
+PF07645 Calcium-binding EGF domain<br>Pfam-B_330 (release 10.0) . 
+PF07646 Kelch motif<br>The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase   for which a structure has been solved  . The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.. 
+PF07647 SAM domain (Sterile alpha motif)<br>
+PF07648 Kazal-type serine protease inhibitor domain<br>Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.. 
+PF07649 C1-like domain<br>This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in Pfam:PF00130.. 
+PF07650 KH domain<br>
+PF07652 Flavivirus DEAD domain <br>Pfam-B_199 (release 3.0). 
+PF07651 ANTH domain<br>AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.\.    The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats [1,2].. 
+PF07653 Variant SH3 domain<br>SH3 (Src homology 3) domains are often indicative of a protein involved in  signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.. 
+PF07654 Immunoglobulin C1-set domain<br>
+PF00008 EGF-like domain<br>Swissprot_feature_table. There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam).  The family is hard to model due to many similar but  different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. . 
+PF07655 Secretin N-terminal domain<br>This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggest that this family may be functionally analogous to Pfam:PF03958.. 
+PF07443 HepA-related protein (HARP)<br>Pfam-B_21761 (release 10.0). This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues  . Family members may contain more than one copy of this region.. 
+PF07657 N terminus of Notch ligand<br>This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins.. 
+PF07659 Domain of Unknown Function (DUF1599)<br>
+PF07660 Secretin and TonB N terminus short domain<br>This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.. 
+PF07661 MORN repeat variant<br>This family represents an apparent variant of the Pfam:PF02493 repeat (personal obs:C Yeats).. 
+PF07662 Na+ dependent nucleoside transporter C-terminus<br>This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane  . Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC  . This alignment covers the C-terminus of this family of transporters.. 
+PF07663 Sorbitol phosphotransferase enzyme II C-terminus<br>TIGRFAMs, Griffiths-Jones SR, Yeats C. 
+PF07664 Ferrous iron transport protein B C terminus<br>Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions  . FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N-terminus has been previously erroneously described as being ATP-binding  . Recent work shows that it is similar to eukaryotic G-proteins and that it is a GTPase  . . 
+PF07666 M penetrans paralogue family 26<br>These proteins include those ascribed to M penetrans paralogue family 26 in  .. 
+PF07667 Protein of unknown function (DUF1600)<br>BLAST clustering of M. penetrans proteome. These proteins appear to be specific to Mycoplasma species.. 
+PF07668 M penetrans paralogue family 1<br>This family of paralogous proteins identified in Mycoplasma penetrans includes homologues of p35  . . 
+PF07669 Eco57I restriction-modification methylase<br>Homologues of the Escherichia coli Eco57I restriction-modification methylase are found in several phylogenetically diverse bacteria. The structure of TaqI has been solved  .. 
+PF07670 Nucleoside recognition<br>This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337)  . In the FeoB proteins (e.g.  Swiss:O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity  . This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.. 
+PF07671 Protein of unknown function (DUF1601)<br>This repeat is found in a small number of proteins and is apparently limited to Coxiella and related species.. 
+PF07672 MFS_Mycoplamsa; <br>Mycoplasma MFS transporter. BLAST clustering of Mycoplasma proteome. These proteins share some similarity with members of the Major Facilitator Superfamily  (MFS).. 
+PF07673 Protein of unknown function (DUF1602)<br>Clustering of A. pernix proteome. 
+PF07675 Cleaved Adhesin Domain<br>This is a family of bacterial protein modules thought to function in various roles including cell adhesion, cell lysis and carbohydrate binding  .  The beta-sandwich jelly-roll topology of these modules is known as the galactose-binding domain-like superfamily, clan CL0202. A tandem repeat of these modules (either two or three repeats) constitute the haemagglutinin/adhesin (HA) regions of the gingipains, RgpA, Swiss:Q51816 and Kgp, Swiss:P72194 and Swiss:P72197   expressed by Porphyromonas gingivalis (Bacteroides gingivalis)  .  They form components of the major extracellular virulence complex RgpA-Kgp - a mixture of proteinases and adhesin domains  . The adhesin domains in this complex are found in proteinase-cleaved forms when isolated from the cell surface  .  Haemagglutinin genes of P. gingivalis   (hagA1 HAGA1_PORGI - Swiss:P59915 - and hagA2 HAGA2_PORGI - Swiss:Q51845) suggest that such proteins are composed of eight to ten tandem repeats of these adhesin modules  . Genomic data predicts that homologous protein modules are also expressed by a number of other bacteria and form part of putative multi-domain proteins, eg. Swiss:Q26BR9 and Swiss:B0VGL6. These domains may be acting in concert with other adhesion modules thought to be part of these multi-domain proteins such as fibronectin type III, Pfam:PF00041, and Meprin, A5, mu (MAM), Pfam:PF00629, domains.. 
+PF07676 WD40-like Beta Propeller Repeat<br>Yeats C, Mistry J, Adindla S. This family appears to be related to the Pfam:PF00400 repeat This This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].. 
+PF07677 A2M2; <br>A-macroglobulin receptor. This family includes the receptor domain region of the alpha-2-macroglobulin family.. 
+PF07678 A2M3; <br>A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.. 
+PF07679 Immunoglobulin I-set domain<br>
+PF07680 TQO small subunit DoxA<br>Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation.  A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Swiss:Q8AAF0.. 
+PF07681 DoxX<br>These proteins appear to have some sequence similarity with Pfam:PF04173 but their function is unknown  .. 
+PF07682 Sulphur oxygenase reductase<br>The sulphur oxygenase/reductase (SOR) of the thermo-acidophilic archaeon Acidianus ambivalens is an unusual enzyme consisting of 24 identical subunits arranged in a perfectly symmetrical hollow sphere and containing a mononuclear non-heme iron centre (personal communication: A. Kletzin). At 85 degrees C in vitro, elemental sulphur is oxidised to sulphite, thiosulphate and hydrogen sulphide with no external cofactors needed. The proposed equation is:  4S + O2 + 4 H2O ---> 2 HSO3- + 2 H2S + 2 H+.. 
+PF07683 Cobalamin synthesis protein cobW C-terminal domain<br>Pfam-B_1247 (release 5.4). This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis   and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family  .. 
+PF07684 NOD; NOD1; <br>NOTCH  signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be  elucidated.. 
+PF07685 CobB/CobQ-like glutamine amidotransferase domain<br>
+PF07686 Immunoglobulin V-set domain<br>This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.. 
+PF07688 KaiA domain<br>The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. The overall fold of the KaiA monomer is that of a four-helix bundle, which forms a dimer in the known structure  .. 
+PF07689 KaiB domain<br>The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and is found to be a dimer  .. 
+PF07690 Major Facilitator Superfamily<br>Pfam-B_5 (Release 13.0). 
+PF07691 PA14 domain<br>Rigden DJ, Mello LV, Galperin MY. This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.. 
+PF07687 Peptidase_M20; <br>Peptidase dimerisation domain. Pfam-B_253 (release 4.0). This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases  . This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification  . Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.. 
+PF07692 HCR1;<br>Low iron-inducible periplasmic protein. Pfam-B_60541 (release 13.0). In Chlamydomonas reinhardtii, the gene encoding Swiss:Q9LD42 is induced by iron deficiency  .  In green algae, this protein is periplasmic. The two paralogues FEA1 and FEA2 are the major proteins secreted by iron-deficient Chlamydomonas reinhardtii, and both are up-regulated in response to iron deficiency. FEA1 but not FEA2 is up-regulated by high CO2 concentration. Both FEA1 and FEA2 are secreted into the periplasmic space and genetic evidence confirms that their association with the cell is required for growth in low iron  .. 
+PF07693 KAP family P-loop domain<br>The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side  .. 
+PF07694 5TMR of 5TMR-LYT<br>This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type)  .. 
+PF07695 7TM diverse intracellular signalling<br>This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules)  .. 
+PF07696 7TMR-DISM extracellular 2<br>This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins  . It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives  .. 
+PF07697 7TM-HD extracellular<br>This entry represents the extracellular domain of the 7TM-HD (7TM Receptors with HD hydrolase)  .. 
+PF07698 7TM receptor with intracellular HD hydrolase<br>These bacterial 7TM receptor proteins have an intracellular Pfam:PF01966.  This entry corresponds to the 7 helix transmembrane domain.  These proteins also contain an N-terminal extracellular domain.. 
+PF07699 GCC2 and GCC3<br>
+PF07700 Heme NO binding<br>The HNOB (Heme NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to  histidine. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce  diverse downstream signals, in both bacteria and animals.. 
+PF07701 Heme NO binding associated<br>The HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce  diverse downstream signals, in both bacteria and animals.. 
+PF07702 UTRA domain<br>The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to Pfam:PF04345  . It is believed to modulate activity of bacterial transcription factors in response to binding small molecules  .. 
+PF07703 Alpha-2-macroglobulin family N-terminal region<br>This family includes a region of the alpha-2-macroglobulin family.. 
+PF07704 Rv0623-like transcription factor<br>This entry represents the Rv0623-like (Swiss:P96913) family of transcription factors associated with the PSK operon  .. 
+PF07705 DUF1604; APHP; <br>Cell adhesion related domain found in bacteria.. 
+PF07706 Aminotransferase ubiquitination site<br>Pfam-B_15367 (release 13.0). This segment contains a probable site of ubiquitination that ensures rapid  degradation of tyrosine aminotransferase in rats.  The half life of the enzyme  in vivo is about  2-4 hours. In addition, unpublished information identifies at least 2 phosphorylation  sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at  S*QEECDK. This region of TAT is probably primarily related to regulatory events.   Most other transaminases are much more stable and are not phosphorylated.. 
+PF07707 BTB And C-terminal Kelch<br>
+PF07708 Tash protein PEST motif<br>This motif is found in the Tash AT-hook proteins of Theileria annulata. These proteins are transported to the hosts nucleus and are likely to be involved in pathogenesis  . It is also often found in conjunction with Pfam:PF04385. It is suggested that they may be 'part of PEST motifs' (a signal for rapid proteolytic degradation) in  ,  though this is not definite. This motif is also found in other T. annulata proteins, which have no other known domains in (unpublished data: C Yeats).. 
+PF07709 Seven Residue Repeat<br>Associated with Pfam:PF02969 in  This repeat is found in some Plasmodium and Theileria proteins.. 
+PF07710 P53 tetramerisation motif<br>Pfam-B_782 (release 3.0). 
+PF07711 Rab geranylgeranyl transferase alpha-subunit, insert domain <br>Pfam-B_20675 (release 13.0) . Rab geranylgeranyl transferase (RabGGT) catalyses the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking  .  This domain is inserted between Pfam:PF01239 repeats.  This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP  .. 
+PF07712 Stress up-regulated Nod 19<br>Pfam-B032880 release 13.0. 
+PF07713 Protein of unknown function (DUF1604)<br>This family is found at the N-terminus of several eukaryotic RNA processing proteins (e.g Swiss:Q8N3B7).. 
+PF07714 Protein tyrosine kinase<br>
+PF07715 TonB-dependent Receptor Plug Domain<br>The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ( ). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.. 
+PF07716 Basic region leucine zipper<br>PfamB-200; Release 14.0;. 
+PF07717 DUF1605;<br>Oligonucleotide/oligosaccharide-binding (OB)-fold. This family is found towards the C-terminus of the DEAD-box helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. There do seem to be a couple of instances where it occurs by itself - e.g. Swiss:Q84VZ2. The structure PDB:3i4u adopts an OB-fold. helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins  .. 
+PF07718 DUF1606; <br>Coatomer beta C-terminal region. This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). This C-terminal domain probably adapts the function of the N-terminal Pfam:PF01602 domain. . 
+PF07719 Tetratricopeptide repeat<br>Context matches from Pfam 14.0. This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by Pfam:PF00515.. 
+PF07720 Tetratricopeptide repeat<br>This Pfam entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones  .. 
+PF07721 Tetratricopeptide repeat<br>This Pfam entry includes tetratricopeptide-like repeats not detected by the Pfam:PF00515, Pfam:PF07719 and Pfam:PF07720 models.. 
+PF07722 Peptidase C26<br>These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C terminus  .. 
+PF07723 Leucine Rich Repeat<br>PfamB-152 (release 14.0). This Pfam entry includes some LRRs that fail to be detected with the Pfam:PF00560 model.. 
+PF07724 AAA domain (Cdc48 subfamily)<br>PfamB-40 (Release 14.0). This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.. 
+PF07726 ATPase family associated with various cellular activities (AAA)<br>PfamB-40 (Release 14.0). This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.. 
+PF07727 Reverse transcriptase (RNA-dependent DNA polymerase)<br>PfamB-40 (Release 14.0). A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses. This Pfam entry includes reverse transcriptases not recognised by the Pfam:PF00078 model.. 
+PF07728 AAA domain (dynein-related subfamily)<br>PfamB-136 (Release 14.0). This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.. 
+PF07729 FCD domain<br>Pfam-B_117 (release 14.0). This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain Pfam:PF00392. This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical  . This family has been named as FCD for (FadR C-terminal Domain).. 
+PF07730 Histidine kinase<br>This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536.. 
+PF07731 Multicopper oxidase<br>PfamB-49 (Release 14.0). This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.. 
+PF07732 Multicopper oxidase<br>PfamB-43 (Release 14.0). This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.. 
+PF07733 Bacterial DNA polymerase III alpha subunit<br>Pfam-B111 (Release 14.0). 
+PF07734 DUF1607; <br>Pfam-B128 (Release 14.0). Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.. 
+PF07735 F-box associated<br>Pfam-B128 (Release 14.0). Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.. 
+PF07736 Chorismate mutase type I<br>Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].. 
+PF07737 Anthrax toxin lethal factor, N- and C-terminal domain<br>Pfam-B_23800 (release 14.0). The C-terminal domain is the catalytically active domain whereas the N-terminal domain is likely to be inactive.. 
+PF07738 Sad1 / UNC-like C-terminal <br>Pfam-B_5052 (release 14.0). The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development.  The S. pombe Sad1 protein localises at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain [1-2]. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2  .  The SUN domain of Sun2 has been demonstrated to be in the periplasm  .. 
+PF07725 Leucine Rich Repeat<br>PfamB-184 (release 14.0). This Pfam entry includes some LRRs that fail to be detected by the Pfam:PF00560 model.. 
+PF07739 TipAS antibiotic-recognition domain<br>Pfam-B_8785 (release 14.0). This domain is found at the C-terminus of some MerR family transcription factors. The domain has an alpha-helical  globin-like fold  . The family includes Mta a central regulator of multidrug resistance in Bacillus subtilis.. 
+PF07740 Ion channel inhibitory toxin<br>Pfam-B_20319 (release 14.0). This is a family of potent toxins that function as ion-channel inhibitors for several different ions. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses  . Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons  . Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels  . Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels  .. 
+PF07741 Brf1-like TBP-binding domain<br>Pfam-B_18050 (release 14.0). This region covers both the Brf homology II and III regions  . This region is involved in binding TATA binding protein  .. 
+PF07742 BTG family<br>Pfam-B_9208 (release 14.0). 
+PF07743 HSCB C-terminal oligomerisation domain<br>Pfam-B_6234 (release 14.0). This domain is the HSCB C-terminal oligomerisation domain and is found on co-chaperone proteins.. 
+PF07744 SPOC domain<br>The SPOC (Spen paralogue and orthologue C-terminal) domain is involved in developmental signalling  .. 
+PF07745 Glycosyl hydrolase family 53<br>Pfam-B_5764 (release 14.0). This domain belongs to family 53 of the glycosyl hydrolase classification  .  These enzymes are enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known   and has a TIM barrel fold.. 
+PF07746 Aromatic-ring-opening dioxygenase LigAB, LigA subunit<br>Pfam-B_18522 (release 14.0). This is a family of aromatic ring opening dioxygenases which catalyse the ring-opening reaction of protocatechuate and related compounds  .. 
+PF07747 MTH865-like family<br>Pfam-B_25445 (release 14.0). This domain has an EF-hand like fold.. 
+PF07748 Glycosyl hydrolases family 38 C-terminal domain<br>Pfam-B_731 (release 3.0). Glycosyl hydrolases are key enzymes of carbohydrate metabolism.. 
+PF07749 Endoplasmic reticulum protein ERp29, C-terminal domain<br>Pfam-B_5062 (release 14.0). ERp29 is a ubiquitously expressed endoplasmic reticulum protein found in mammals.  ERp29 is comprised of two domains. This domain, the C-terminal domain, has an all helical fold  . ERp29 is thought to form part of the thyroglobulin folding complex  .. 
+PF07750 GcrA cell cycle regulator<br>Pfam-B_23428 (release 14.0). GcrA is a master cell cycle regulator that, together with CtrA (see Pfam:PF00072 and Pfam:PF00486), is involved in controlling cell cycle progression and asymmetric polar morphogenesis  . During this process, there are temporal and spatial variations in the concentrations of GcrA and CtrA.  The variation in concentration produces time and space dependent transcriptional regulation of modular functions that implement cell-cycle processes  .  More specifically, GcrA acts as an activator of components of the replisome and the segregation machinery  .. 
+PF07751 Abi-like protein<br>Pfam-B_8740 (release 14.0). This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins,  which are involved in bacteriophage resistance mediated by  abortive infection in Lactococcus species [1,2]. The  proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function  .. 
+PF07752 DUF1608;<br>Fenech M, Eberhardt RY. Pfam-B_2293 (release 14.0). Archaeal S-layer proteins consist of two copies of this domain [1-2].. 
+PF07753 Protein of unknown function (DUF1609)<br>Pfam-B_2149 (release 14.0). This region is found in a number of hypothetical proteins thought to be expressed by the eukaryote Encephalitozoon cuniculi, an obligate intracellular  microsporidial parasite. It is approximately 200  residues long.. 
+PF07754 Domain of unknown function (DUF1610)<br>Pfam-B_8731 (release 14.0). This zinc ribbon domain is found in archaeal species. It is likely to bind zinc via its four well-conserved cysteine residues.. 
+PF07755 Protein of unknown function (DUF1611)<br>Pfam-B_8752 (release 14.0). This region is found in a number of hypothetical bacterial and archaeal proteins. The region is  approximately 350 residues long. A member of this family (Swiss:Q6M063) is thought to associate with another subunit to form an H+-transporting ATPase, but no evidence has been found to support this.. 
+PF07756 Protein of unknown function (DUF1612)<br>Pfam-B_8688 (release 14.0). This family includes sequences of largely unknown function but which share a number of features in common. They are expressed by bacterial species,  and in many cases these bacteria are known to  associate symbiotically with plants. Moreover, the majority are coded for by plasmids, which in many cases are known to confer on the organism the ability to interact symbiotically with  leguminous plants. An example of such a plasmid is NGR234, which encodes Y4CF, a protein of unknown function that is a member of this family  . Other  members of this family are expressed by organisms with a documented genomic similarity to plant symbionts  .. 
+PF07757 DUF1613; <br>Predicted AdoMet-dependent methyltransferase. Pfam-B_8934 (release 14.0). Proteins in this family have been predicted to function as AdoMet-dependent methyltransferases  .. 
+PF07758 Protein of unknown function (DUF1614)<br>Pfam-B_8844 (release 14.0). This is a family of sequences coming from hypothetical proteins found in both bacterial and archaeal species.. 
+PF07759 Protein of unknown function (DUF1615)<br>Pfam-B_8943 (release 14.0). This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. Swiss:Q8Z8Z7, Swiss:Q8ZRF4) are thought to be lipoproteins. Another member of this family (Swiss:Q93SV8) is thought to be involved in photosynthesis  .. 
+PF07760 Protein of unknown function (DUF1616)<br>Pfam-B_8886 (release 14.0). This is a family of sequences from hypothetical archaeal proteins.  The region in question is approximately 330 amino acid residues long.. 
+PF07761 Protein of unknown function (DUF1617)<br>Pfam-B_8981 (release 14.0). This is a family of sequences from hypothetical bacterial and bacteriophage proteins. The region in question is approximately 150 residues long and is highly conserved throughout the family.. 
+PF07762 Protein of unknown function (DUF1618)<br>Pfam-B_8857 (release 14.0). The members of this family are mainly hypothetical proteins expressed by Oryza sativa.. 
+PF07763 FEZ-like protein<br>Pfam-B_8854 (release 14.0). This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation  . The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic  .  The C. elegans homolog, UNC-76 (Swiss:Q7JNU9), may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells  ) and these roles have also been postulated for other FEZ family proteins  . Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells  . The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta  . The members of this family are predicted to form coiled-coil structures [2,3], which may interact with members of the RhoA family of signalling proteins  , but are not thought to contain other characteristic protein motifs  . Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2, Swiss:Q76LN0) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues  .. 
+PF07764 Omega Transcriptional Repressor<br>Pfam-B_63922 (release 14.0). The omega transcriptional repressor regulates expression of involved in copy number control and stable maintenance of plasmids. The omega protein belongs to the structural superfamily of MetJ/Arc repressors featuring a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA  .. 
+PF07765 KIP1-like protein<br>Pfam-B_2332 (release 14.0). This is a family of sequences found exclusively  in plants. They are similar to kinase interacting protein 1 (KIP1), which has been found to interact with the kinase domain of PRK1, a receptor-like  kinase  . This particular region contains two  coiled-coils, which are described as motifs involved in protein-protein interactions  . It has also been suggested that the protein's coiled- coils allow it to dimerise in vivo  .. 
+PF07766 LETM1-like protein<br>Fenech M, Wood V, Mistry J. Pfam-B_2202 (release 14.0). Members of this family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen  ion exchange  . Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans  .. 
+PF07767 P60;<br>Nop53 (60S ribosomal biogenesis). Fenech M, Wood V, Mistry J. Pfam-B_8778 (release 14.0). This nucleolar family of proteins are involved in 60S ribosomal biogenesis.  They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation  . This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60)  . This protein has been found to interact with herpes simplex type 1 regulatory proteins  .. 
+PF07768 PVL ORF-50-like family<br>Pfam-B_8834 (release 14.0). This is a family of sequences found in both bacteria and bacteriophages. This region is approximately 130 residues long and in some cases is found as part of the PVL (Panton-Valentine leukocidin) group of genes, which encode a member of the leukocidin group of bacterial toxins that kill leukocytes by creation of pores in the cell membrane  . PVL appears to be a virulence factor associated with a number of human diseases  .. 
+PF07769 psiF repeat<br>Pfam-B_8872 (release 14.0). This region is approximately 35 residues long. It is found repeated in a number of putative phosphate starvation- inducible proteins expressed by various bacterial species. psiF (Swiss:Q7AH28) is known to be an example of such phosphate starvation-inducible proteins  .. 
+PF07771 Tick salivary peptide group 1<br>Pfam-B_2333 (release 14.0). This contains a group of peptides derived from a salivary gland cDNA library of the tick Ixodes scapularis  . Also present are peptides from a related tick species, Ixodes  ricinus. They are characterised by a putative signal peptide indicative of secretion and conserved cysteine residues.. 
+PF07773 Protein of unknown function (DUF1619)<br>Pfam-B_8790 (release 14.0). This is a family of sequences derived from hypothetical eukaryotic proteins. The region in question is approximately 330 residues long and has a cysteine rich amino-terminus.. 
+PF07774 Protein of unknown function (DUF1620)<br>Pfam-B_8944 (release 14.0). These sequences are mainly derived from predicted eukaryotic proteins. The region in question lies towards the C-terminus of these large proteins and is approximately 300 amino acid residues long.. 
+PF07775 PaRep2b protein<br>Pfam-B_4098 (release 14.0). This is a family of proteins, expressed in the crenarchaeon Pyrobaculum aerophilum, whose members are variable in  length and level of conservation. The presence of numerous frameshifts and internal stop codons in multiple alignments are thought to indicate that most family members are no longer  functional  . . 
+PF07776 Zinc-finger associated domain (zf-AD)  <br>Pfam-B_14442 (release 14.0). The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold.  The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA  .. 
+PF07777 G-box binding protein MFMR<br>Pfam-B_5000 (release 14.0). This region is found to the N-terminus of the Pfam:PF00170 transcription factor domain.  It is between 150 and 200 amino acids in length. The N-terminal half is rather rich in proline residues and has been termed the PRD (proline rich domain)  , whereas the C-terminal half is more polar and has been called the MFMR (multifunctional mosaic region). It has been suggested that this family is composed of three sub-families called A, B and C  , classified according to  motif composition. It has been suggested that some of these motifs may be involved in mediating protein-protein interactions  . The MFMR region contains a nuclear localisation signal in bZIP opaque and GBF-2  . The MFMR also contains a transregulatory activity in TAF-1. The MFMR in CPRF-2 contains cytoplasmic retention signals  .. 
+PF07778 Mis6;<br>Pfam-B_17323 (release 13.0). Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis [1,2].. 
+PF07779 10 TM Acyl Transferase domain found in Cas1p<br>Cas1p protein of Cryptococcus neoformans is required for the  synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence  . The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase  superfamily  . This superfamily is comprised of members from the  OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family  . The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity  .. 
+PF07780 Spb1 C-terminal domain<br>Pfam-B_5001 (release 14.0). This presumed domain is found at the C-terminus of a family of FtsJ-like methyltransferases. Members of this family are involved in 60S ribosomal biogenesis, for example Swiss:P25582  .. 
+PF07781 Reovirus minor core protein Mu-2<br>Pfam-B_9308 (release 14.0). This family represents the Reovirus core protein Mu-2. Mu-2 is a microtubule associated protein and is thought to play a key role in the formation and structural organisation of reovirus inclusion bodies  . . 
+PF07782 DC-STAMP-like protein<br>Pfam-B_9122 (release 14.0). This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP, Swiss:Q9H295). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins  . It is thought to have seven putative transmembrane regions  , two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC  , but these are not conserved throughout the family.. 
+PF07784 Protein of unknown function (DUF1622)<br>Pfam-B_9062 (release 14.0). This is a family of 14 highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.. 
+PF07785 Protein of unknown function (DUF1623)<br>Pfam-B_9100 (release 14.0). The members of this family are all derived from  relatively short hypothetical proteins thought to  be expressed by various Nucleopolyhedroviruses.. 
+PF07786 Protein of unknown function (DUF1624)<br>Pfam-B_9180 (release 14.0). These sequences are found in hypothetical proteins of unknown function expressed by bacterial and  archaeal species. The region in question is approximately 230 residues long.. 
+PF07787 Protein of unknown function (DUF1625)<br>Pfam-B_8907 (release 14.0). Sequences making up this family are derived from  hypothetical proteins expressed by both prokaryotic and eukaryotic species. The region in question is  approximately 250 residues long.. 
+PF07788 Protein of unknown function (DUF1626)<br>Pfam-B_9705 (release 14.0). This is a family consisting of sequences from hypothetical proteins of unknown function expressed by certain species of archaebacteria. One member (Swiss:Q9YCN7) is thought to be similar to tropomyosin  .. 
+PF07789 Protein of unknown function (DUF1627)<br>Pfam-B_9837 (release 14.0). This is a group of sequences found in hypothetical proteins predicted to be expressed in a number of  bacterial species. The region in question is  approximately 150 amino acid residues long.. 
+PF07790 Protein of unknown function (DUF1628)<br>Pfam-B_5107 (release 14.0). The sequences making up this family are derived from hypothetical proteins of unknown function  expressed by various archaeal species. The region  in question is approximately 160 residues long.. 
+PF07791 Protein of unknown function (DUF1629)<br>Pfam-B_9012 (release 14.0). This family consists of sequences from hypothetical proteins thought to be expressed by two members of the Xanthomonas genus. The region in question is 125 amino acid residues long.. 
+PF07792 DUF1630;<br>Docking domain of Afi1 for Arf3 in vesicle trafficking. Pfam-B_9160 (release 14.0). This domain occurs at the N-terminal of Afi1, an Arf3p-interacting protein, is a protein necessary for vesicle trafficking in yeast. This domain is the interacting region of the protein which binds to Arf3, the highly conserved small GTPases (ADP-ribosylation factors). Afi1 is distributed asymmetrically at the plasma membrane and is required for polarized distribution of Arf3 but not of an Arf3 guanine nucleotide-exchange factor, Yel1p. However, Afi1 is not required for targeting of Arf3 or Yel1p to the plasma membrane. Afi1 functions as an Arf3 polarization-specific adapter and participates in development of polarity. Although Arf3 is the homologue of human Arf6 it does not function in the same way, not being necessary for endocytosis or for mating factor receptor internalization. In the S phase, however, it is concentrated at the plasma membrane of the emerging bud. Because of its polarized localisation and its critical function in the normal budding pattern of yeast, Arf3 is probably a regulator of vesicle trafficking, which is important for polarized growth.. 
+PF07793 Protein of unknown function (DUF1631)<br>Pfam-B_9170 (release 14.0). The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned  is approximately 440 amino acid residues in length.. 
+PF07794 Protein of unknown function (DUF1633)<br>Pfam-B_9750 (release 14.0). This family contains sequences derived from a group of hypothetical proteins expressed  by Arabidopsis thaliana. These sequences are  highly similar and the region concerned is  about 100 residues long.. 
+PF07795 Protein of unknown function (DUF1635)<br>Pfam-B_9707 (release 14.0). The members of this family include sequences that are parts of hypothetical proteins expressed by plant species. The region in question is about 170 amino acids long.. 
+PF07796 Protein of unknown function (DUF1638)<br>Pfam-B_6091 (release 14.0) & Pfam-B_3149 (release 23.0). This family contains sequences covering an approximately 270 amino acid stretch of a group of hypothetical proteins.\.   These proteins are expressed by archaeal species of the Methanosarcina genus.. 
+PF07797 Protein of unknown function (DUF1639)<br>Pfam-B_6036 (release 14.0). This approximately 50 residue region is found in a  number of sequences derived from hypothetical plant proteins. This region features a highly basic 5 amino-acid stretch towards its centre.. 
+PF07798 Protein of unknown function (DUF1640)<br>Pfam-B_6194 (release 14.0). This family consists of sequences derived from  hypothetical eukaryotic proteins. A region approximately 100 residues in length is featured. . 
+PF07799 Protein of unknown function (DUF1643)<br>Pfam-B_9851 (release 14.0). The members of this family are all sequences found within hypothetical proteins expressed  by various bacterial species. The region  concerned is approximately 150 residues long.. 
+PF07800 Protein of unknown function (DUF1644)<br>Pfam-B_5078 (release 14.0). This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.. 
+PF07801 Protein of unknown function (DUF1647)<br>Fenech M, Pollington J. Pfam-B_5249 (release 14.0). The sequences making up this family are all derived from hypothetical proteins expressed by C. elegans. The region in question is approximately 160 amino acids long. The GO annotation for this protein indicates the protein to be involved in nematode larval development and to have a positive regulation on growth rate.. 
+PF07802 GCK domain<br>Pfam-B_8992 (release 14.0). This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as Pfam:PF00071) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family (such as Swiss:Q9LMF3); this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerisation.. 
+PF07803 GSG1-like protein<br>Pfam-B_9727 (release 14.0). This family contains sequences bearing similarity to a region of GSG1 (Swiss:Q9Z1H7), a protein specifically expressed in testicular germ cells  . It is possible that overexpression of the human  homolog may be involved in tumourigenesis of human testicular germ cell tumours  . The region in question  has four highly-conserved cysteine residues.. 
+PF07804 HipA-like C-terminal domain<br>Pfam-B_8632 (release 14.0). The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis  . When expressed alone, it is toxic to bacterial  cells  , but it is usually tightly associated with  HipB  , and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with  cell division genes or their products  .. 
+PF07805 HipA-like N-terminal domain<br>Pfam-B_8632 (release 14.0). The members of this family are similar to a region close to the N-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis  . When expressed alone, it is toxic to bacterial  cells  , but it is usually tightly associated with  HipB  , and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with  cell division genes or their products  .. 
+PF07806 Nodule-specific GRP repeat<br>Pfam-B_8942 (release 14.0). The region featured in this family is found repeated in a number of plant proteins, some of which are expressed specifically in nodules formed during symbiotic interactions with certain bacterial species  . Some of these proteins are also termed glycine-rich proteins (GRPs), due to the presence of a glycine-rich C-terminal region in their structures  . Bacterial infection is required for the induction of nodule-specific GRP genes, and it is thought that nodule-specific GRPs may play non-redundant roles required at specific stages of nodule development  . Members of this group of proteins may be cytosolic, whereas others are thought to be membrane-associated  .. 
+PF07807 RED-like protein C-terminal region<br>Pfam-B_9789 (release 14.0). This family contains sequences that are similar to the  C-terminal region of Red protein (Swiss:Q13123). This and  related proteins are thought to be localised to the nucleus,  and contain a RED repeat which consists of a number of RE and  RD sequence elements  . The region in question has several  conserved NLS sequences  . The function of Red protein is unknown,  but efficient sequestration to nuclear bodies suggests that its  expression may be tightly regulated or that the protein self-aggregates extremely efficiently  .. 
+PF07808 RED-like protein N-terminal region<br>Pfam-B_9780 (release 14.0). This family contains sequences that are similar to the N-terminal region of Red protein (Swiss:Q13123). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements  . The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region  , suggesting that these proteins are expressed in the nucleus  . The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently  .. 
+PF07809 RTP801 C-terminal region<br>Pfam-B_5179 (release 14.0). The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene  . Two members of this family expressed by Drosophila melanogaster, Scylla (Swiss:Q9NHN4) and Charybde (Swiss:Q9NHN5), are designated by the GenBank as Hox targets  .  RTP801 is thought to be involved in various cellular processes  .  Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells  . Moreover, the protein product of the mouse homolog of RTP801 (dig2 (Swiss:Q9D3F7)) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment  .. 
+PF07810 TMC domain<br>Pfam-B_5063 (release 14.0). These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 (Swiss:Q7TN63) and EVIN2 (Swiss:Q8IU68) - this region is termed the TMC domain  .  Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis  . TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters  .. 
+PF07811 TadE-like protein<br>Pfam-B_9054 (release 14.0). The members of this family are similar to a region of  the protein product of the bacterial tadE locus (Swiss:Q9S4A6). In various bacterial species, the tad locus is closely  linked to flp-like genes, which encode proteins required  for the production of pili involved in adherence to  surfaces  . It is thought that the tad loci encode  proteins that act to assemble or export an Flp pilus in  various bacteria  . All tad loci but TadA have putative transmembrane regions  , and in fact the region in  question is this family has a high proportion of hydrophobic  amino acid residues.. 
+PF07812 TfuA-like protein<br>Pfam-B_9826 (release 14.0). This family consists of a group of sequences that are similar to a region of TfuA protein (Swiss:Q52872). This protein is involved in the production of trifolitoxin (TFX), an gene-encoded, post-translationally modified peptide antibiotic  . The role of TfuA in TFX synthesis is unknown, and it may be involved in other cellular processes  .. 
+PF07813 LTXXQ motif family protein<br>Pfam-B_6101 (release 14.0). This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP (Swiss:P32158). This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH  . Another member of this family, Spy (Swiss:P77754) is also a periplasmic protein that may be involved in the response to stress  . The homology between CpxP and Spy may indicate that these two proteins are functionally related  .. 
+PF07814 Wings apart-like protein regulation of heterochromatin<br>Pfam-B_9039 (release 14.0). This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure  . hWAPL (Swiss:Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein  . Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death  .. 
+PF07815 Abl-interactor HHR<br>Pfam-B_9732 (release 14.0). The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact  with Abl-family tyrosine kinases  . More specifically,  it is termed the homeo-domain homologous region (HHR), as it  is similar to the DNA-binding region of homeo-domain  proteins  . Other homeo-domain proteins have been  implicated in specifying positional information during embryonic development, and in the regulation of the expression of  cell-type specific genes  . The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved  in cytoskeletal reorganisation, but their precise role remains  unclear  .. 
+PF07816 Protein of unknown function (DUF1645)<br>Pfam-B_8798 (release 14.0). These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.. 
+PF07817 GLE1-like protein<br>Pfam-B_9182 (release 14.0). The members of this family are sequences that are similar to the human protein GLE1 (Swiss:O75458). This protein is localised at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm [1,2].. 
+PF07818 HCNGP-like protein<br>Pfam-B_9462 (release 14.0). This family comprises sequences bearing significant  similarity to the mouse transcriptional regulator  protein HCNGP (Swiss:Q02614). This protein is localised to the nucleus and is thought to be involved in the  regulation of beta-2-microglobulin genes.. 
+PF07819 PGAP1-like protein<br>Pfam-B_9244 (release 14.0). The sequences found in this family are similar to PGAP1 (Swiss:Q765A7). This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is  conserved in a number of lipases. PGAP1 functions as a  GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body  .. 
+PF07820 TraC-like protein<br>Pfam-B_9690 (release 14.0). The members of this family are sequences that are similar to TraC (Swiss:Q84HT8). The gene encoding this protein is one of a group of genes found on plasmid p42a of Rhizobium etli CFN42 that are thought to be involved in the process of plasmid self-transmission. Mobilisation of plasmid p42a is of importance as it is required for transfer of plasmid p42a, which is also known as plasmid pSym as it carries most of the genes required for nodulation and nitrogen fixation by the symbiotic bacterium. The predicted protein products of p42a are similar to known transfer proteins of Agrobacterium tumefaciens plasmid pTiC58  .. 
+PF07821 Alpha-amylase C-terminal beta-sheet domain<br>Pfam-B_1278 (release 14.0). This domain is organised as a five-stranded  anti-parallel beta-sheet [1,2]. It is the  probable result of a decay of the common-fold.. 
+PF07822 Neurotoxin B-IV-like protein<br>Pfam-B_66513 (release 14.0). The members of this family resemble neurotoxin B-IV (Swiss:P01525), which is a crustacean-selective neurotoxin produced by the marine worm Cerebratulus lacteus. This highly cationic peptide is approximately 55 residues and is arranged to form two antiparallel helices connected by a well-defined loop in a hairpin structure. The branches of the hairpin are linked by four disulphide bonds. Three residues identified as being important for activity, namely Arg-17, -25 and -34, are found on the same face of the molecule, while another residue important for activity, Trp30, is on the opposite side. The protein's mode of action is not entirely understood, but it may act on voltage-gated sodium channels, possibly by binding to an as yet uncharacterised site on these proteins. Its site of interaction may also be less specific, for example it may interact with negatively charged membrane lipids  .. 
+PF07823 Cyclic phosphodiesterase-like protein<br>Pfam-B_73368 (release 14.0). Cyclic phosphodiesterase (CPDase, Swiss:O04147) is involved in the tRNA splicing pathway. This protein exhibits a bilobal arrangement of two alpha-beta modules. Two antiparallel helices are found on the outer side of each lobe and frame an antiparallel beta-sheet that is wrapped around an accessible cleft.  Moreover, the beta-strands of each lobe interact with the other lobe. The central water-filled cavity houses the enzyme's active site  .. 
+PF07824 Type III secretion chaperone domain<br>Pfam-B_32938 (release 14.0). Type III secretion chaperones are involved in delivering virulence effector proteins from  bacterial pathogens directly into eukaryotic cells. The chaperones may prevent aggregation and degradation of their substrates, may target the effector to the  secretion apparatus, and may ensure a secretion-component unfolded confirmation of their specific substrate. One member of this family, SigE (Swiss:O30917) forms  homodimers in crystal. The monomers have a novel fold  with an alpha-beta(3)-alpha-beta(2)-alpha topology  .. 
+PF07825 Excisionase-like protein<br>Pfam-B_46296 (release 14.0). The phage-encoded excisionase protein (Xis, Swiss:P03699) is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual 'winged'-helix structure in which two alpha helices are packed against two extended strands.  Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue 'wing'.  During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of Xis is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DNA  .. 
+PF07826 IMP cyclohydrolase-like protein<br>Pfam-B_50235 (release 14.0). This enzyme (Swiss:O27099) is may catalyse the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily.  A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family  .. 
+PF07827 KNTase C-terminal domain<br>Pfam-B_29524 (release 14.0). Kanamycin nucleotidyltransferase (KNTase) is involved  in conferring resistance to aminoglycoside antibiotics  and catalyses the transfer of a nucleoside monophosphate  group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains.  The C-terminal domain contains five alpha helices, four of which are organised into an up-and-down alpha helical  bundle. Residues found in this domain may contribute to this enzyme's active site  .. 
+PF07828 PA-IL-like protein<br>Pfam-B_99281 (release 14.0). The members of this family are similar to the galactophilic  lectin-1 expressed by P. aeruginosa ((PA-IL, Swiss:Q05097).  Lectins recognising specific carbohydrates found on the  surface of host cells are known to be involved in the  initiation of infections by this organism. The protein is thought to be organised into an extensive network of beta-sheets, as is the case with many other lectins  .. 
+PF07829 Alpha-A conotoxin PIVA-like protein<br>Pfam-B_46690 (release 14.0). Alpha-A conotoxin PIVA (Swiss:P55963) is the major paralytic  toxin found in the venom produced by the piscivorous snail  Conus purpurascens. This peptide acts by blocking the  acetylcholine binding site of the nicotinic acetylcholine receptor at the neuromuscular junction  . The overall shape of the peptide is described as an "iron" with a highly charged  hydrophilic loop of 15S-19R forming the "handle" domain that  is exposed to the exterior of the protein. The stability of  the conotoxin is primarily governed by three disulphide bonds. A triangular structural motif formed by residues 19R, 12H and  6Y is thought to constitute a "binding core" that is important in binding to the acetylcholine receptor  .. 
+PF07830 Protein serine/threonine phosphatase 2C, C-terminal domain<br>Pfam-B_5253 (release 14.0). Protein phosphatase 2C (PP2C) is involved in regulating  cellular responses to stress in various eukaryotes. It  consists of two domains: an N-terminal catalytic domain  and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices,  one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not  seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain  .. 
+PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain<br>Pfam-B_1661 (release 14.0). This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases [1,2]. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP, Swiss:P77826) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP, Swiss:P07650)  . The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer  .. 
+PF07832 Cfr10I/Bse634I restriction endonuclease<br>Pfam-B_46671 (release 14.0). Cfr10I (Swiss:P56200) and Bse634I (Swiss:Q8RT53) are two Type II restriction endonucleases. They exhibit a conserved  tetrameric architecture that is of functional importance, wherein two dimers are arranged 'back-to-back' with their  putative DNA-binding clefts facing opposite directions.  These clefts are formed between two monomers that interact, mainly via hydrophobic interactions supported by a few hydrogen bonds, to form a U-shaped dimer. Each monomer is folded to form a compact alpha-beta structure, whose core is made up of a five-stranded mixed beta-sheet.The monomer may be split into  separate N-terminal and C-terminal subdomains at a hinge located in helix alpha3  .. 
+PF07833 Copper amine oxidase N-terminal domain<br>Pfam-B_46519 (release 14.0). Copper amine oxidases catalyse the oxidative deamination  of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These  enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in  some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other [1,2].. 
+PF07834 RanGAP1 C-terminal domain<br>Pfam-B_23411 (release 14.0). Ran-GTPase activating protein 1 (RanGAP1, Swiss:P46061) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localisation at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1, Swiss:Q93068). This domain is composed almost entirely of helical substructures that are organised into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation  .. 
+PF07835 Bacterial aa3 type cytochrome c oxidase subunit IV<br>Pfam-B_86185 (release 14.0). Bacterial cytochrome c oxidase is found bound to the  to the cell membrane, where it is involved in the  generation of the transmembrane proton electrochemical gradient. It is composed of four subunits. Subunit IV consists of one transmembrane helix that does not interact  directly with the other subunits, but maintains its position by indirect contacts via phospholipid molecules found in the structure. The function of subunit IV is as yet unknown  .. 
+PF07836 DmpG-like communication domain<br>Pfam-B_1675 (release 14.0). This domain is found towards the C-terminal region  of various aldolase enzymes. It consists of five  alpha-helices, four of which form an antiparallel helical bundle that plugs the C-terminus of the N-terminal TIM barrel domain  . The communication domain is thought to play an important role in the  heterodimerisation of the enzyme  .. 
+PF07837 Formiminotransferase domain, N-terminal subdomain<br>Pfam-B_4434 (release 14.0). The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This,  in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a  short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to  form a number of contacts with residues found in both the N-terminal and C-terminal subdomains  .. 
+PF07839 Plant calmodulin-binding domain<br>Pfam-B_9279 (release 14.0). The sequences featured in this family are found repeated  in a number of plant calmodulin-binding proteins (such as Swiss:Q8W235, Swiss:Q84ZT8 and Swiss:Q8H6X1), and are  thought to constitute the calmodulin-binding domains [1,2]. Binding of the proteins to calmodulin depends on the presence of calcium ions [1,2]. These proteins are thought to be  involved in various processes, such as plant defence responses   and stolonisation or tuberization  .. 
+PF07840 FadR C-terminal domain<br>Pfam-B_11411 (release 14.0). This family contains sequences that are similar to the fatty acid metabolism regulator protein (FadR, Swiss:P09371). This functions as a dimer, with each monomer being composed of an N-terminal DNA-binding domain and a regulatory C-terminal domain. A linker comprising two short alpha helices joins the two domains. In the C-terminal domain, an antiparallel array of six alpha helices forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain. This structure was found to be similar to that of the C-terminal domain of the Tet repressor. Long-chain acyl-CoA thioesters interact directly and reversibly with the C-terminal domain, and this interaction affects the structure and therefore the DNA binding properties of the N-terminal domain  .. 
+PF07841 DM4/DM12 family<br>Pfam-B_5243 (release 14.0). This family contains sequences derived from hypothetical proteins expressed by two insect species, D. melanogaster and A. gambiae. The region in question is approximately 115 amino acid residues long and contains four highly- conserved cysteine residues.. 
+PF07842 GC-rich sequence DNA-binding factor-like protein<br>Fenech M, Mistry J, Wood V. Pfam-B_9357 (release 14.0) & Pfam-B_9894 (release 19.0). Sequences found in this family are similar to a region of a human GC-rich sequence DNA-binding factor homolog (Swiss:Q9Y5B6). This is thought to be a protein involved in transcriptional regulation due to partial homologies  to a transcription repressor and histone-interacting protein   . This family also contains tuftelin interacting protein 11 which has been identified as both a nuclear and cytoplasmic protein, and has been implicated in the secretory pathway.  Sip1, a septin interacting protein   is also a member of this family.. 
+PF07843 Protein of unknown function (DUF1634)<br>Pfam-B_9594 (release 14.0). This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many  hydrophobic residues.. 
+PF07845 Protein of unknown function (DUF1636)<br>Pfam-B_9608 (release 14.0). The sequences featured in this family are derived from a number of hypothetical prokaryotic proteins. The region in question is approximately 130 amino acids long.. 
+PF07846 Metallothio_7;<br>Metallothionein family. Pfam-B_9622 (release 14.0). The sequences making up Metallothio_Cad are found repeated in metallothionein proteins expressed by several different Tetrahymena species. Metallothioneins are low molecular mass, cysteine-rich metal-binding proteins that are thought to be involved in the regulation of levels of trace metals, and detoxification of these metals when present in excess  . Some of the metallothioneins found in this family (for example, Swiss:Q8T6B3) are known to be induced by cadmium and are thought to be involved in the cellular sequestration of toxic metal ions. The high proportion of cysteine residues allows the metal ions to be bound by the formation of clusters of metal-thiolate complexes  . Tetrahymena spp. metallothioneins differ from other eukaryotic metallothioneins mainly in the length of their sequences and in the cysteine-containing motifs they exhibit.. 
+PF07847 Protein of unknown function (DUF1637)<br>Pfam-B_6051 (release 14.0). This family contains many eukaryotic hypothetical proteins. The region featured in this family is approximately 120 residues long. According to InterPro annotation, some members of this family may belong to the cupin superfamily.. 
+PF07848 PaaX-like protein<br>Pfam-B_9563 (release 14.0). This family contains proteins that are similar to the product  of the paaX gene of Escherichia coli (Swiss:P76086). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid  .  In fact, some members of this family are annotated by InterPro as  containing a winged helix DNA-binding domain (Interpro:IPR009058).. 
+PF07849 Protein of unknown function (DUF1641)<br>Pfam-B_9217 (release 14.0). Archaeal and bacterial hypothetical proteins are found in this family, with the region in question  being approximately 40 residues long.. 
+PF07850 Renin receptor-like protein<br>Pfam-B_9266 (release 14.0). The sequences featured in this family are similar to a region of the human renin receptor (Swiss:Q8NG15) that bears a putative transmembrane spanning segment  .  The renin receptor is involved in intracellular signal  transduction by the activation of the ERK1/ERK2 pathway,  and it also serves to increase the efficiency of angiotensinogen  cleavage by receptor-bound renin, therefore facilitating  angiotensin II generation and action on a cell surface  .. 
+PF07851 TMPIT-like protein<br>Pfam-B_9674 (release 14.0). A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.. 
+PF07852 Protein of unknown function (DUF1642)<br>Pfam-B_9838 (release 14.0). The sequences making up this family are derived from various hypothetical phage and prophage proteins. The region in question is approximately 140 amino acids long.. 
+PF07853 Protein of unknown function (DUF1648)<br>Pfam-B_9801 (release 14.0). Members of this family are hypothetical proteins  expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane  proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.. 
+PF07854 Protein of unknown function (DUF1646)<br>Pfam-B_9337 (release 14.0). Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei (Swiss:Q8PXG5, Swiss:Q8PXG7 and Swiss:Q8PXG8).. 
+PF07855 Protein of unknown function (DUF1649)<br>Pfam-B_9402 (release 14.0). This family is made up of sequences derived from hypothetical eukaryotic proteins of unknown function. . 
+PF07856 DUF1650; Orai-1_Ce; <br>Mediator of CRAC channel activity. Fenech M, Pollington JE. Pfam-B_9685 (release 14.0). ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins  .. 
+PF07857 CEO family (DUF1632)<br>Pfam-B_9654 (release 14.0). These sequences are found in hypothetical eukaryotic proteins of unknown function. The region concerned is approximately 280 residues long. This family has been termed the CEO family for C. elegans ORF  .. 
+PF07858 Limonene-1,2-epoxide hydrolase catalytic domain<br>Pfam-B_15033 (release 14.0). Epoxide hydrolases catalyse the hydrolysis of epoxides to corresponding diols, which is important in detoxification, synthesis of signal molecules, or metabolism. Limonene-1,2- epoxide hydrolase (LEH) differs from many other epoxide hydrolases in its structure and its novel one-step catalytic mechanism. Its main fold consists of a six-stranded mixed beta-sheet, with three N-terminal alpha helices packed to one side to create a pocket that extends into the protein core. A fourth helix lies in such a way that it acts as a rim to this pocket. Although mainly lined by hydrophobic residues, this pocket features a cluster of polar groups that lie at its deepest point and constitute the enzyme's active site  .. 
+PF07859 alpha/beta hydrolase fold<br>Pfam-B_100 (release 15.0). This catalytic domain is found in a very wide range of enzymes.. 
+PF07860 WisP family C-Terminal Region<br>This family is found at the C-terminus of the Tropheryma whipplei WisP family proteins ( ).. 
+PF07861 WisP family N-Terminal Region<br>This family is found at the N-terminus of the Tropheryma whipplei WisP family proteins ( ).. 
+PF07862 Nitrogen fixation protein of unknown function<br>This domain is found in the Cyanobacteria, and may be involved in nitrogen fixation, but no role has been assigned ( ).. 
+PF07863 Homologues of TraJ from Bacteroides conjugative transposon<br>Members of this family have been implicated in as being involved in an unusual form of DNA transfer (conjugation) in Bacteroides ( ). The family has been named CtnDOT_TraJ to avoid confusion with other conjugative transfer systems.. 
+PF07864 Protein of unknown function (DUF1651)<br>This is a family containing bacterial proteins of unknown function.. 
+PF07865 Protein of unknown function (DUF1652)<br>This is a family containing hypothetical bacterial proteins.. 
+PF07866 Protein of unknown function (DUF1653)<br>This is a family of hypothetical bacterial proteins of unknown function.. 
+PF07867 Protein of unknown function (DUF1654)<br>This family consists of proteins from the Pseudomonadaceae.. 
+PF07868 Protein of unknown function (DUF1655)<br>This protein is found in some prophages found in Lactobacillales lactis ( ).. 
+PF07869 Protein of unknown function (DUF1656)<br>This family contains bacterial proteins, many of which are hypothetical.  Some proteins in this family are putative membrane proteins.. 
+PF07870 Protein of unknown function (DUF1657)<br>This domain appears to be restricted to the Bacillales.. 
+PF07871 Protein of unknown function (DUF1658)<br>This family of small proteins seems to be found in several places in the Coxiella genome.. 
+PF07872 Protein of unknown function (DUF1659)<br>This family consists of hypothetical bacterial proteins of unknown function.. 
+PF07873 YabP family<br>This family of proteins is involved in spore coat assembly during the process of sporulation  .. 
+PF07874 Prophage protein (DUF1660)<br>This protein is found in Lactobacillae prophages.. 
+PF07875 Coat F domain<br>The Coat F proteins, which contribute to the Bacillales spore coat.  It occurs multiple times in the genomes it is found in.. 
+PF07876 Stress responsive A/B Barrel Domain<br>The function of this family is unknown, but it is upregulated in response to salt stress in Populus balsamifera ( ). It is also found at the C-terminus of an fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus (Swiss:Q9ZA13;  ). Swiss:Q93NG5 is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved (Swiss:Q9LUV2) and the domain forms an a/b barrel dimer ( ). Although there is a clear duplication within the domain it is not obviously detectable in the sequence.. 
+PF07877 Protein of unknown function (DUF1661)<br>This is a family containing bacterial proteins of unknown function.  Many of the proteins in this family are hypothetical.. 
+PF07878 Protein of unknown function (DUF1662)<br>This family contains bacterial proteins of unknown function. This domain belongs to the Ribbon-helix-helix superfamily suggesting these may be DNA-binding proteins.. 
+PF07879 PHB/PHA accumulation regulator DNA-binding domain<br>This domain is found at the N-terminus of the Polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA ( ). The invariant nature of this domain compared to the C-terminal Pfam:PF05233 domain(s) suggests that it contains the DNA-binding function.. 
+PF07880 Bacteriophage T4 gp9/10-like protein<br>Pfam-B_73396 (release 14.0). The members of this family are similar to gene products 9 (gp9) and 10 (gp10) of bacteriophage T4. Both proteins are components of the viral baseplate  . Gp9 (Swiss:P10927) connects the long tail fibres of the virus to the baseplate and triggers tail contraction after viral attachment to a host cell. The protein is active as a trimer, with each monomer being composed of three domains.  The N-terminal domain consists of an extended polypeptide chain and two alpha helices. The alpha1 helix from each of the three monomers in the trimer interacts with its counterparts to form a coiled-coil structure. The middle domain is a seven-stranded beta-sandwich that is thought to be a novel protein fold. The C-terminal domain is thought to be essential for gp9 trimerisation and is organised into an eight- stranded antiparallel beta-barrel, which was found to resemble the 'jelly roll' fold found in many viral capsid proteins. The long flexible region between the N-terminal and middle domains may be required for the function of gp9 to transmit signals from the long tail fibres  . Together with gp11, gp10 (Swiss:P10928) initiates the assembly of wedges that then go on to associate with a hub to form the viral baseplate  .. 
+PF07881 L-fucose isomerase, first N-terminal domain<br>Pfam-B_11456 (release 14.0). The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis,  and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta-sheets with surrounding  alpha helices. Domain 1 demonstrates the beta-alpha-beta-alpha- beta Rossman fold. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting  residues, and domain 1 from the adjacent subunit contributing some other residues  .. 
+PF07882 L-fucose isomerase, second N-terminal domain<br>Pfam-B_11456 (release 14.0). The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage.  The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues  .. 
+PF07883 Cupin domain<br>Pfam-B_81 (release 15.0). This family represents the conserved barrel domain of the 'cupin' superfamily   ('cupa' is the Latin term for a small barrel).. 
+PF07884 Vitamin K epoxide reductase family<br>Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1 is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea  . Four cysteine residues and one residue, which is either serine or threonine, are identified as likely active-site residues  . In some plant and bacterial homologues the VKORC1 homologous domain is fused with domains of the thioredoxin family of oxidoreductases  .. 
+PF07885 Ion channel<br>Pfam-B_55 (release 15.0). This family includes the two membrane helix type ion channels found in bacteria.. 
+PF07886 BA14K-like protein<br>Pfam-B_4068 (release 14.0). The sequences found in this family are similar to the BA14K proteins expressed by Brucella abortus (Swiss:Q44701) and by Brucella suis (Swiss:Q8FVU0).  BA14K was found to be strongly immunoreactive; it induces both humoral and cellular responses in hosts throughout the infective process  .. 
+PF07887 Calmodulin binding protein-like<br>Pfam-B_4579 (release 14.0). The members of this family are putative or actual calmodulin binding proteins expressed by various plant  species. Some members (for example, Swiss:Q8H6T7), are known to be involved in the induction of plant defence responses  . However, their precise function in this regards is as yet unknown.. 
+PF07888 CoCoA; <br>Calcium binding and coiled-coil domain (CALCOCO1) like. Pfam-B_4504 (release 14.0). Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1, Swiss:Q8CGU1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 (Swiss:Q61026), and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region  .. 
+PF07889 Protein of unknown function (DUF1664)<br>Pfam-B_4797 (release 14.0). The members of this family are hypothetical plant proteins of unknown function. The region  featured in this family is approximately 100  amino acids long.. 
+PF07890 DUF1665; <br>Fenech M, Mistry J, Wood V. Pfam-B_9434 (release 14.0). Rrp15p is required for the formation of 60S ribosomal subunits  .. 
+PF07891 Protein of unknown function (DUF1666)<br>Pfam-B_9387 (release 14.0). These sequences are derived from hypothetical plant proteins of unknown function. The region in question  is approximately 250 residues long.. 
+PF07892 Protein of unknown function (DUF1667)<br>Pfam-B_9631 (release 14.0). Hypothetical archaeal and bacterial proteins make up this family. A few proteins are annotated as being potential metal-binding proteins, and in fact the members of this family have four highly conserved cysteine residues, but no further literature evidence was found in this regard.. 
+PF07893 Protein of unknown function (DUF1668)<br>Pfam-B_5066 (release 14.0). The hypothetical proteins found in this family are  expressed by Oryza sativa and are of unknown function.. 
+PF07894 Protein of unknown function (DUF1669)<br>Pfam-B_9335 (release 14.0). This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.. 
+PF07895 Protein of unknown function (DUF1673)<br>Pfam-B_4746 (release 14.0). This family contains hypothetical proteins of unknown function expressed by two archaeal species.. 
+PF07896 Protein of unknown function (DUF1674)<br>Pfam-B_4326 (release 14.0). The members of this family are sequences derived from hypothetical eukaryotic and bacterial proteins. The  region in question is approximately 60 residues long.. 
+PF07897 Protein of unknown function (DUF1675)<br>Pfam-B_4280 (release 14.0). The members of this family are sequences derived from hypothetical plant proteins of unknown function. One member of this family (Swiss:Q9SFV5) is annotated as  a putative RNA-binding protein, but no evidence was found to support this.. 
+PF07898 Protein of unknown function (DUF1676)<br>Pfam-B_4779 (release 14.0). This family contains sequences derived from proteins of unknown function expressed by Drosophila melanogaster and Anopheles gambiae.. 
+PF07899 Frigida-like protein<br>Pfam-B_4728 (release 14.0). This family is composed of plant proteins that are similar to FRIGIDA protein expressed by Arabidopsis thaliana (Swiss:Q9FDW0). This protein is probably nuclear and is required for the regulation of flowering time in the late-flowering phenotype. It is known to increase RNA levels of flowering locus C. Allelic variation at the FRIGIDA locus is a major determinant of natural variation in flowering time  .. 
+PF07900 Protein of unknown function (DUF1670)<br>Pfam-B_9559 (release 14.0). The hypothetical eukaryotic proteins found in this family are of unknown function.. 
+PF07901 Protein of unknown function (DUF1672)<br>Pfam-B_9698 (release 14.0). This family is composed of hypothetical bacterial proteins of unknown function.. 
+PF07902 gp58-like protein<br>Pfam-B_4289 (release 14.0). Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58 (Swiss:Q38355), a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H  .. 
+PF07903 PaRep2a protein<br>Pfam-B_4102 (release 14.0). This is a family of proteins expressed by the  crenarchaeon Pyrobaculum aerophilum. The members  are highly variable in length and level of conservation.  The presence of numerous frameshifts and internal stop  codons in multiple alignments are thought to indicate  that most family members are no longer functional  .. 
+PF07904 CT20;<br>Chromatin modification-related protein EAF7. The S. cerevisiae member of this family Swiss:P53911 is part of NuA4, the only essential histone acetyltransferase complex in Saccharomyces cerevisiae involved in global histone acetylation  .. 
+PF07905 Purine catabolism regulatory protein-like family<br>Pfam-B_4388 (release 14.0). The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, Swiss:O32138). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain.  It is similar to LysR-type regulators in that it represses its own expression  . The other members of this family are also annotated as being putative regulatory proteins.. 
+PF07906 ShET2 enterotoxin, N-terminal region<br>Pfam-B_4512 (release 14.0). The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri (Swiss:Q47635) and Escherichia coli (Swiss:Q47634). This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system  . Most members of this family are annotated as putative enterotoxins, but one member (Swiss:Q8X606) is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (Pfam:PF00023).. 
+PF07907 YibE/F-like protein<br>Pfam-B_4781 (release 14.0). The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE (Swiss:Q9CHC5) and YibF (Swiss:Q9CHC4). Most of the members of this family are annotated as being putative  membrane proteins, and in fact the sequences contain  a high proportion of hydrophobic residues.. 
+PF07908 D-aminoacylase, C-terminal region<br>Pfam-B_13711 (release 14.0). D-aminoacylase (Swiss:Q9AGH8, EC:3.5.1.81) hydrolyses a wide variety  of N-acyl derivatives of neutral D-amino acids, in a zinc-dependent  manner. The enzyme is composed of a small beta-barrel domain and a  larger catalytic alpha/beta-barrel. The C-terminal region featured  in this family forms part of the beta-barrel domain, together with  a short N-terminal segment. The beta-strands of both barrels were  found to superimpose well. The small beta-barrel domain does not  seem to contribute to the substrate-binding site or to be involved  in the catalytic process  .. 
+PF07909 Protein of unknown function (DUF1663)<br>Pfam-B_4106 (release 14.0). The members of this family are hypothetical proteins expressed by Trypanosoma cruzi, a  eukaryotic parasite that causes Chagas' disease in humans. This region is found as multiple copies per protein.. 
+PF07910 DUF1671; <br>Peptidase family C78. Pfam-B_9699 (release 14.0). This family formerly known as DUF1671 has been shown to be a cysteine peptidase called (Ufm1)-specific protease  .. 
+PF07911 Protein of unknown function (DUF1677)<br>Pfam-B_4922 (release 14.0). The sequences found in this family are all derived from hypothetical plant proteins of unknown function. The region features a number of highly conserved cysteine residues.. 
+PF07912 ERp29, N-terminal domain<br>Pfam-B_28781 (release 14.0). ERp29 (Swiss:P52555) is a ubiquitously expressed endoplasmic reticulum protein, and is involved in  the processes of protein maturation and protein  secretion in this organelle [1,2]. The protein exists as a homodimer, with each monomer being  composed of two domains. The N-terminal domain  featured in this family is organised into a  thioredoxin-like fold that resembles the a domain  of human protein disulphide isomerase (PDI)  .  However, this domain lacks the C-X-X-C motif  required for the redox function of PDI; it is  therefore thought that ERp29's function is similar  to the chaperone function of PDI  . The N-terminal domain is exclusively responsible for the homodimerisation of the protein, without covalent linkages or additional contacts with other domains  .. 
+PF07913 Protein of unknown function (DUF1678)<br>Pfam-B_4886 (release 14.0). This family is composed of uncharacterized proteins expressed by Methanopyrus kandleri, a hyperthermophilic archaebacterium. . 
+PF07914 Protein of unknown function (DUF1679)<br>Pfam-B_4694 (release 14.0). The region featured in this family is found in a number of  C. elegans proteins, in one case (Swiss:Q19034) as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family (Swiss:Q9GUC1) is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins  (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).. 
+PF07915 Glucosidase II beta subunit-like protein<br>Pfam-B_9407 (release 14.0). The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing  . The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum  . Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown  .  This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.. 
+PF07916 TraG-like protein, N-terminal region<br>Fenech M, Mistry J, Coggill P. Pfam-B_4841 (release 14.0) & Pfam-B_689 (release 23.0). The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein (Swiss:P33790).  This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions  . TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly [1,2]. The protein is thought to interact with the periplasmic domain of TraN (Swiss:P24082) to stabilise mating-cell interactions  .. 
+PF07918 CAP160 repeat<br>Pfam-B_9359 (release 14.0). This region featured in this family is repeated in spinach cold acclimation protein CAP160 (Swiss:O50054) CAP160 is induced during periods of drought stress; its precise function is unknown but it has been implicated in the stabilisation of membranes, cytoskeletal elements, and ribosomes. By acting as a compatible solute, it may reduce the toxic effects of cellular solutes that accumulate at high concentration during dehydration; it may also function as an enzyme that produces such a solute  . Other members of this family are also induced by water stress, abscisic acid, and/or low temperature, such as desiccation-responsive protein 29B (Swiss:Q04980) and CDet11-24 protein (Swiss:O23764).. 
+PF07919 DUF1683;<br>Gryzun, putative trafficking through Golgi. Fenech M, Pollington J. Pfam-B_9179 (release 14.0). The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun (Swiss:Q7Z392) blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex.. 
+PF07920 Protein of unknown function (DUF1684)<br>Pfam-B_9328 (release 14.0). The sequences featured in this family are found in hypothetical archaeal and bacterial proteins  of unknown function. The region in question is approximately 200 amino acids long.. 
+PF07921 Fibritin C-terminal region<br>Pfam-B_31175 (release 14.0). This family features sequences bearing similarity to the C-terminal portion of the bacteriophage T4 protein fibritin (Swiss:P10104). This protein is responsible for attachment of long tail fibres to virus particle, and forms the 'whiskers' or fibres on the neck of the virion. The region seen in this family contains an N-terminal coiled-coil portion and the C-terminal globular foldon domain (residues 457-486), which is essential for fibritin trimerisation and folding  . This domain consists of a beta-hairpin; three such hairpins come together in a beta-propeller-like arrangement in the trimer, which is stabilised by hydrogen bonds, salt bridges and hydrophobic interactions  .. 
+PF07922 Glycosyltransferase family 52<br>Pfam-B_2778 (release 14.0). This family features glycosyltransferases belonging to  glycosyltransferase family 52  , which have alpha-2,3- sialyltransferase (EC:4.2.99.4) and alpha-glucosyltransferase  (EC 2.4.1.-) activity. For example, beta-galactoside alpha-2,3- sialyltransferase expressed by Neisseria meningitidis (Swiss:P72097) is a member of this family and is involved in a step of lipooligosaccharide  biosynthesis requiring sialic acid transfer; these lipooligosaccharides  are thought to be important in the process of pathogenesis  . This family includes several bacterial lipooligosaccharide sialyltransferases similar to the Haemophilus ducreyi LST protein. Haemophilus ducreyi is the cause of the sexually transmitted disease chancroid and produces a lipooligosaccharide (LOS) containing a terminal sialyl N-acetyllactosamine trisaccharide  .  . 
+PF07923 N1221-like protein<br>Pfam-B_9309 (release 14.0). The sequences featured in this family are similar to a hypothetical protein product of ORF N1221 in the CPT1-SPC98 intergenic region of the yeast genome (Swiss:P53917). This encodes an acidic polypeptide with several possible transmembrane regions  .. 
+PF07924 Nuclease A inhibitor-like protein<br>Pfam-B_43172 (release 14.0). This family consists of protein sequences that are similar to the nuclease A inhibitor expressed by bacteria of the genus Anabaena ((NuiA, Swiss:Q44296). This sequence is organised to form an alpha-beta-alpha sandwich fold, which is similar to the PR-1-like fold.  NuiA interacts with nuclease A by means of residues located at one end of the molecule, including residues making up the loop between helices III and IV and the loop between strands C and D.  The mechanism of inhibition of nuclease A by NuiA is as yet incompletely understood  .. 
+PF07925 Reovirus RNA-dependent RNA polymerase lambda 3<br>Pfam-B_9372 (release 14.0). The sequences in this family are similar to the reoviral minor core protein lambda 3 (Swiss:P17378), which functions as a RNA-dependent RNA polymerase within the protein capsid.\.      It is organised into 3 domains. N- and C-terminal domains create a 'cage' that encloses a conserved central catalytic domain within a hollow centre; this catalytic domain is arranged to form 'fingers', 'palm' and 'thumb' subdomains.  Unlike other RNA polymerases, like HIV reverse transcriptase and T7 RNA polymerase, lambda 3 protein binds template and substrate with only localised rearrangements, and catalytic activity can occur with little structural change. However, the structure of the catalytic complex is similar to that of other polymerase catalytic complexes with known structure  .. 
+PF07926 TPR/MLP1/MLP2-like protein<br>Pfam-B_9285 (release 14.0). The sequences featured in this family are similar to a region of human TPR protein (Swiss:P12270) and to yeast myosin-like proteins 1 (MLP1, Swiss:Q02455) and 2 (MLP2, Swiss:P40457). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores [1,2,3]. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments  , and is implicated in nuclear protein import  . Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex  . MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity  .. 
+PF07927 YcfA-like protein<br>Pfam-B_2914 (release 14.0). The viral, archaeal and bacterial proteins making up this family are similar to the YcfA protein expressed by E.  coli (Swiss:Q9F561). Most of these proteins are hypothetical proteins of unknown function.. 
+PF07928 Vps54-like protein<br>Pfam-B_9294 (release 14.0). This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog  (Swiss:Q9JMK8), the human homolog (Swiss:Q86YF7), and  the mouse homolog (Swiss:Q8R3X1). In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex  that is involved in protein transport between Golgi, endosomal, and vacuolar compartments  . All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs  .. 
+PF07929 Plasmid pRiA4b ORF-3-like protein<br>Pfam-B_4929 (release 14.0). Members of this family are similar to the protein product of ORF-3 (Swiss:Q44206) found on plasmid  pRiA4 in the bacterium Agrobacterium rhizogenes.  This plasmid is responsible for tumourigenesis at  wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process  . Other proteins found in this family are annotated as being putative TnpR resolvases (Swiss:Q9LCU7, Swiss:Q50439), but no  further evidence was found to back this. Moreover,  another member of this family is described as a probable  lexA repressor (Swiss:Q7UEI4) and in fact carries a LexA  DNA binding domain (Pfam:PF01726), but no references were  found to expand on this.. 
+PF07930 D-aminopeptidase, domain B<br>Pfam-B_29283 (release 14.0). D-aminopeptidase (Swiss:Q9ZBA9) is a dimeric enzyme with each monomer being composed of three domains. Domain B is organised to form a beta barrel made up of eight antiparallel beta strands. It is connected  to domain A, the catalytic domain, by an eight-residue sequence, and also interacts with both domains A and C  via non-covalent bonds. Domain B probably functions in maintaining domain C in a good position to interact with domain A  .. 
+PF07931 Chloramphenicol phosphotransferase-like protein<br>Pfam-B_29509 (release 14.0). The members of this family are all similar to chloramphenicol  3-O phosphotransferase (CPT, Swiss:Q56148) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group  to the C-3 hydroxyl group of Cm, CPT inactivates this potentially  lethal metabolite  .. 
+PF07932 D-aminopeptidase, domain C<br>Pfam-B_29283 (release 14.0). D-aminopeptidase (Swiss:Q9ZBA9) is a dimeric enzyme with each monomer being composed of three domains. Domain C is organised to form a beta barrel made up of eight antiparallel beta strands. It is connected to domain B by a short linker sequence, and interacts extensively with the domain A, the catalytic domain. The gamma loop of domain C forms part of the wall of the catalytic pocket; domain C is in fact thought to confer substrate and inhibitor specificity to the enzyme  .. 
+PF07933 Protein of unknown function (DUF1681)<br>Pfam-B_4989 (release 14.0). This family is composed of sequences derived from a  number of hypothetical eukaryotic proteins of unknown  function.. 
+PF07934 8-oxoguanine DNA glycosylase, N-terminal domain<br>Pfam-B_29151 (release 14.0). The presence of 8-oxoguanine residues in DNA can give rise  to G-C to T-A transversion mutations. This enzyme is found  in archaeal, bacterial and eukaryotic species, and is  specifically responsible for the process which leads to the  removal of 8-oxoguanine residues. It has DNA glycosylase  activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18)   . The region featured in this family is the N-terminal  domain, which is organised into a single copy of a TBP-like  fold. The domain contributes residues to the 8-oxoguanine binding pocket  .. 
+PF07935 ORF D-335-like protein<br>Pfam-B_4933 (release 14.0). The sequences featured in this family are similar to  a probable integrase (Swiss:P20214) expressed by the SSV1 virus of the archaebacterium Sulfolobus shibatae. This protein may be necessary for the integration of the virus into the host genome by a process of site-specific  recombination  .. 
+PF07936 BDS_I_II;<br>Potassium-channel blocking toxin. Pfam-B_56105 (release 14.0). This family features the antihypertensive and antiviral proteins BDS-I (Swiss:P11494) and BDS-II (Swiss:P59084) expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N-terminus  . Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure  . Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism  .. 
+PF07937 Protein of unknown function (DUF1686)<br>Pfam-B_5313 (release 14.0). The members of this family are all hypothetical proteins of unknown function expressed by the eukaryotic parasite Encephalitozoon cuniculi GB-M1. The region in question is approximately 250 amino acids long.. 
+PF07938 Fungal fucose-specific lectin<br>Pfam-B_48600 (release 14.0). Lectins are involved in many recognition events at the molecular or cellular level. These fungal lectins, such as Aleuria aurantia lectin (AAL,  Swiss:P18891), specifically recognise fucosylated  glycans. AAL is a dimeric protein, with each monomer  being organised into a six-bladed beta-propeller fold and a small antiparallel two-stranded beta-sheet. The beta-propeller fold is important in fucose recognition; five binding pockets are found between the propeller blades. The small beta-sheet, on the other hand, is involved in the dimerisation process  . . 
+PF07939 Protein of unknown function (DUF1685)<br>Pfam-B_5502 (release 14.0). The members of this family are hypothetical eukaryotic proteins of unknown function. The region in question is approximately 100 amino acid residues long.. 
+PF07940 Heparinase II/III-like protein<br>Pfam-B_5577 (release 14.0). This family features sequences that are similar to  a region of the Flavobacterium heparinum proteins heparinase II (Swiss:Q46080) and heparinase III (Swiss:Q59289). The former is known to degrade heparin and heparan sulphate, whereas the latter predominantly degrades heparan sulphate. Both are secreted into the periplasmic space upon induction with heparin  .. 
+PF07941 Potassium channel Kv1.4 tandem inactivation domain<br>Pfam-B_7603 (release 14.0). This family features the tandem inactivation domain found at the N-terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N-terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to being about fast inactivation of the Kv1.4 channel, which is important for the channel's role in short-term plasticity  .. 
+PF07942 N2227-like protein<br>Pfam-B_5433 (release 14.0). This family features sequences that are similar to a region of hypothetical yeast gene product N2227 (Swiss:P53934). This is thought to be expressed during meiosis and may be involved in the defence response to stressful conditions  .. 
+PF07943 Penicillin-binding protein 5, C-terminal domain<br>Pfam-B_1086 (release 14.0). Penicillin-binding protein 5 expressed by E. coli (Swiss:P04287) functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (Pfam:PF00768) is the catalytic domain.  The C-terminal domain featured in this family is organised into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides  .. 
+PF07944 Putative glycosyl hydrolase of unknown function (DUF1680)<br>Pfam-B_4918 (release 14.0). The members of this family are sequences derived from hypothetical bacterial and eukaryotic proteins of unknown function. One members of this family is annotated as a possible arabinosidase, but no references were found to back this. These proteins are related to a large family of glycosyl hydrolases.. 
+PF07945 Janus-atracotoxin<br>Pfam-B_50381 (release 14.0). This family includes three peptides secreted by the  spider Hadronyche versuta (Swiss:P82226, Swiss:P82227, Swiss:P82228). These are insect-selective, excitatory neurotoxins that may function by antagonising muscle  acetylcholine receptors, or acetylcholine receptor  subtypes present in other invertebrate neurons  . Janus atracotoxin-Hv1c (J-ACTX-Hv1c, Swiss:P82228) is organised into a disulphide-rich globular core (residues 3-19) and a beta-hairpin (residues 20-34). There are  4 disulphide bridges, one of which is a vicinal disulphide bridge; this is known to be unimportant in the maintenance  of structure but critical for insecticidal activity  .. 
+PF07946 Protein of unknown function (DUF1682)<br>Pfam-B_4955 (release 14.0). The members of this family are all hypothetical eukaryotic proteins of unknown function. One  member (Swiss:Q920S6) is described as being an adipocyte-specific protein, but no evidence of this was found.. 
+PF07947 YhhN-like protein<br>Pfam-B_5325 (release 14.0). The members of this family are similar to the hypothetical protein yhhN expressed by E. coli (Swiss:P37616). Many of the members  of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues.. 
+PF07948 Nairovirus M polyprotein-like<br>Pfam-B_5426 (release 14.0). The sequences in this family are similar to the Dugbe virus M polyprotein precursor (Swiss:Q02004), which includes glycoproteins G1 and G2. Both are  thought to be inserted in the membrane of the Golgi complex of the infected host cell, and G1 is known to have a role in infection of vertebrate hosts  .. 
+PF07949 YbbR-like protein<br>Pfam-B_4990 (release 14.0). The members of this family are are all hypothetical bacterial proteins of unknown function, and are  similar to the YbbR protein expressed by Bacillus  subtilis (Swiss:O34659, Swiss:O87088). One member (Swiss:Q97EN2) is annotated as an uncharacterized secreted protein, whereas another member (Swiss:P43521) is described as a hypothetical protein in the 5'region  of the def gene of Thermus thermophilus, which encodes  a deformylase  , but no further information was found  in either case. This region is found repeated up to four times in many members of this family.. 
+PF07950 Protein of unknown function (DUF1691)<br>This family of fungal proteins is uncharacterised. Each protein contains two copies of this region.. 
+PF07951 Clostridium neurotoxin, C-terminal receptor binding<br>Pfam-B_3087 (release 15.0). The Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains  .  This domains is the C-terminal receptor binding domain, which adopts a modified beta-trefoil fold with a six stranded beta-barrel and a beta-hairpin triplet capping the domain  . The first step in the intoxication process is a binding event between this domains and the pre-synaptic nerve ending  .. 
+PF07952 Clostridium neurotoxin, Translocation domain<br>Pfam-B_4943 (release 15.0). The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains  . Subsequent to cell surface binding and receptor mediated endocytosis of the neurotoxin, an acid induced conformational change in the neurotoxin translocation domain is believed to allow the domain to penetrate the endosome and from a  pore, thereby facilitating the passage of the catalytic domain across the membrane into the cytosol  . The structure of the translocation reveals a pair of helices that are 105 Angstroms long and is structurally distinct from  other pore forming toxins  .. 
+PF07953 Clostridium neurotoxin, N-terminal receptor binding<br>Pfam-B_1058 (release 15.0). The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains  . This domains is the N-terminal receptor binding domain,which is  comprised of two seven-stranded beta-sheets sandwiched together to form a jelly role motif  . The role of this domain in receptor binding appears to be indirect.. 
+PF07954 Protein of unknown function (DUF1689) <br>Family of fungal proteins with unknown function. A member of this family has been found to localise in the  mitochondria  .. 
+PF07955 Protein of unknown function (DUF1687) <br>This is a putative redox protein which is predicted to have a thioredoxin fold containing a single active cysteine  .. 
+PF07956 Protein of Unknown function (DUF1690) <br>Family of uncharacterised fungal proteins.. 
+PF07957 Ribosomal_MRP8; <br>Protein of unknown function (DUF3294). This family was annotated as mitochondrial Ribosomal protein MRP8, based on the presumed similarity of the S.cerevisiae protein to an E.coli mitochondrial ribosomal protein; however, this similarity is spurious, and the function is not known [Wood, V].. 
+PF07958 Protein of unknown function (DUF1688)<br>A family of uncharacterised proteins.. 
+PF07959 L-fucokinase<br>Pfam-B_121298 (release 15.0). In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by L-fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalysed by GDP-L-fucose pyrophosphorylase  .. 
+PF07960 CBP4<br>The CBP4 in S. cerevisiae is essential for the expression and activity  of ubiquinol-cytochrome c reductase [1,2].  This family appears to be  fungal specific.. 
+PF07961 MBA1-like protein<br>Mba1 is an inner membrane protein that is part of the mitochondrial protein export machinery   .  It binds to the large subunit of mitochondrial ribosomes and cooperates with the C-terminal ribosome-binding domain of Oxa1, which is a central component of the insertion machinery of the inner membrane. In the absence of both Mba1 and the C-terminus of Oxa1, mitochondrial translation products fail to be properly inserted into the inner membrane and serve as substrates of the matrix chaperone Hsp70  .  It is proposed that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosome exit site to the insertion machinery of the inner membrane  .. 
+PF07962 Replication Fork Protection Component Swi3<br>Pfam-B_9217 (release 15.0). Replication fork pausing is required to initiate a recombination events.  More specifically, Swi1 is required for recombination near the mat1 locus.  Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilises stalled replication forks  . The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling [1,2]. 
+PF07963 Prokaryotic N-terminal methylation motif<br>Pfam-B_6484 (release 14.0). This short motif directs methylation of the conserved phenylalanine residue.  It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596.. 
+PF07964 Rec10 / Red1<br>Rec10 / Red1 is involved in meiotic recombination and chromosome  segregation during homologous chromosome formation.  This protein  localises to the synaptonemal complex in S. cerevisiae and the analogous structures (linear elements) in S. pombe  . This family is currently only found in fungi.. 
+PF07965 Integrin beta tail domain<br>Pfam-B_1876 (release 14.0). This is the beta tail domain of the Integrin protein.  Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.. 
+PF07966 A1 Propeptide <br>Pfam-B_386 (release 15.0). Most eukaryotic endopeptidases (Merops Family A1) are synthesised with signal and propeptides.  The animal pepsin-like endopeptidase propeptides form a distinct family of propeptides, which contain a conserved motif approximately 30 residues long. In pepsinogen A, the first 11 residues of the mature pepsin sequence are displaced by residues of the propeptide.  The propeptide contains two helices that block the active site cleft, in particular the conserved Asp11 residue, in pepsin, hydrogen bonds to a conserved Arg residues in the propeptide.  This hydrogen bond stabilises the propeptide conformation and is probably responsible for triggering the conversion of pepsinogen to pepsin under acidic conditions [1,2].. 
+PF07967 C3HC zinc finger-like <br>This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in  nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling  events  . The domain is often repeated, with the second domain usually containing  a large insert (approximately 90 residues) after the first three  cysteine residues. The Schizosaccharomyces pombe the protein containing this domain  (Swiss:O94506) is involved in mRNA export from the nucleus  .. 
+PF07968 Leukocidin/Hemolysin toxin family<br>
+PF07969 Amidohydrolase family<br>Pfam-B_751 (release 15.0). 
+PF07970 DUF1692; Erv41; Erv46; <br>Endoplasmic reticulum vesicle transporter . Pfam-B_2028 (release 16.0). This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi  .. 
+PF07971 Glycosyl hydrolase family 92<br>Pfam-B_1199 (release 16.0). Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation  .. 
+PF07972 NrdI Flavodoxin like <br>Pfam-B_1603 (release 16.0). 
+PF07973 Threonyl and Alanyl tRNA synthetase second additional domain<br>Pfam-B_270 (release 16.0). The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain).  The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain  .. 
+PF07974 EGF-like domain<br>Pfam-B_80 (Release 16.0). This family contains EGF domains found in a variety of extracellular proteins.. 
+PF07975 TFIIH C1-like domain<br>Pfam-B_10678 (release 16.0). The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif.  The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (Pfam:PF00130)  .. 
+PF07976 Phenol hydroxylase, C-terminal dimerisation domain <br>Pfam-B_19435 (release 16.0). Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product.  The enzyme is comprised of three domains.  The first two domains from the active site.  The third domain, this domain, is involved in forming the dimerisation interface.  The domain adopts a thioredoxin-like fold  . . 
+PF07977 FabA-like domain<br>This enzyme domain has a HotDog fold.. 
+PF07978 NIPSNAP <br>Pfam-B_3436 (release 16.0). Members of this family include many hypothetical proteins.  It also  includes members of the NIPSNAP family which have putative roles in  vesicular transport  .  This domain is often found in duplicate.  . 
+PF07979 Intimin C-type lectin domain<br>Pfam-B_1879 (Release 16.0). This domain is found at the C-terminus of intimin. Its structure has been solved and shown to have a C-lectin type of structure  . Intimin is a bacterial adhesion molecule involved in intimate attachment of enteropathogenic and enterohemorrhagic Escherichia coli to mammalian host cells. Intimin targets the translocated intimin receptor (Tir), which is exported by the bacteria and integrated into the host cell plasma membrane.. 
+PF07980 SusD_RagB;<br>Pfam-B_1855 (release 16.0). This family includes several hypothetical proteins.  It also contains RagB, Swiss:Q9ZA59, a protein involved in signalling   and SusD, Swiss:Q8A1G2, an outer membrane protein involved in nutrient binding  .. 
+PF07981 Plasmodium repeat_MYXSPDY<br>Pfam-B_3138 (release 16.0). This repeat is found in two hypothetical Plasmodium proteins.. 
+PF07982 Herpes UL74 glycoproteins <br>Pfam-B_3076 (release 16.0). Members of this family are viral glycoproteins that form part of an  envelope complex  .. 
+PF07983 X8 domain<br>Pfam-B_374 (Release 16.0). The X8 domain   domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen   as well as at the C-terminus of several families of glycosyl hydrolases  . This domain may be involved in carbohydrate binding. This domain is characteristic of GPI-anchored domains [4,5].. 
+PF07984 Domain of unknown function (DUF1693) <br>Pfam-B_3630 (release 16.0). This family contains many hypothetical proteins.  It also includes four nematode prion-like proteins. This domain has been identified as part of the nucleotidyltransferase superfamily  .. 
+PF07985 SRR1<br>Pfam-B_29119 (release 16.0). SRR1 proteins are signalling proteins involved in regulating the  circadian clock in Arabidopsis .. 
+PF07986 Tubulin binding cofactor C<br>Pfam-B_4111 (release 16.0). Members of this family are involved in the folding pathway of tubulins and form a beta helix structure  .. 
+PF07987 Bacterial_GLE1; <br>Domain of unkown function (DUF1775). Pfam-B_12641 (release 16.0). Domain found in bacteria with undetermined function. Its structure has been determined and is an immunoglobulin-like fold.. 
+PF07988 Wos2;<br>Pfam-B_4851 (release 16.0). This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.. 
+PF07989 Spindle_assoc; <br>Microtubule associated. Pfam-B_45034 (release 16.0). This presumed domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules  . The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB)  .. 
+PF07990 Nucleic acid binding protein NABP<br>Pfam-B_10222 (release 16.0). Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterised   and  contains two putative phosphorylation sites and a possible dimerisation  / leucine zipper domain.. 
+PF07991 Acetohydroxy acid isomeroreductase, catalytic domain<br>Prodom_2380 (release 99.1). Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine.. 
+PF07992 Pyridine nucleotide-disulphide oxidoreductase<br>This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.. 
+PF07993 Male sterility protein<br>Pfam-B_1115 (release 6.4). This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila.  A sequence-related jojoba acyl CoA reductase is also included.. 
+PF07994 Myo-inositol-1-phosphate synthase<br>Pfam-B_959 (release 4.1). This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated  to inositol  . Inositol phosphates play an important role in  signal transduction.. 
+PF07995 Glucose / Sorbosone dehydrogenase<br>Pfam-B_1863 (release 16.0). Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.. 
+PF07996 Type IV secretion system proteins<br>Pfam-B_4497 (release 16.0). Members of this family  are components of the type IV  secretion system.  They mediate intracellular transfer of macromolecules via a mechanism ancestrally related to that of bacterial conjugation  machineries   .. 
+PF07997 Protein of unknown function (DUF1694)<br>Pfam-B_4517 (release 16.0). This family contains many hypothetical proteins.. 
+PF07998 DUF1695; <br>Peptidase family M54. Pfam-B_4509 (release 16.0). This is a family of metallopeptidases.  Two human proteins have been reported to degrade synthetic substrates and peptides  .. 
+PF07999 Retrotransposon hot spot protein<br>Pfam-B_4567 (release 16.0). Members of this family are retrotransposon hot spot proteins.  They  are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop motif.. 
+PF08000 DUF1696;<br>Pfam-B_4657 (release 16.0). This family contains many bacterial hypothetical proteins. The structures of Swiss:A1SD03, PDB:3hsa, and Swiss:A3QB43, PDB:3dcx, show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in  cell envelope stress response  .. 
+PF08001 CMV US<br>Pfam-B_4698 (release 16.0). This is a family of unique short (US) cytoplasmic glycoproteins which are expressed in cytomegalovirus  .. 
+PF08002 Protein of unknown function (DUF1697)<br>Pfam-B_4800 (release 16.0). This family contains many hypothetical bacterial proteins.. 
+PF08003 DUF1698; <br>Protein of unknown function (DUF1698). Pfam-B_4787 (release 16.0). This family contains many hypothetical proteins.  It also includes two  putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.. 
+PF08004 Protein of unknown function (DUF1699)<br>Pfam-B_4896 (release 16.0). This family contains many archaeal proteins which have very conserved sequences.  . 
+PF08005 PHR domain <br>This domain is called PHR as it was original found in the proteins PAM (Swiss:O75592), highwire (Swiss:Q9NB71) and RPM (Swiss:Q17551)  .  This domain can be duplicated in the highwire, PFAM and PRM sequence.\.      The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils  .. 
+PF08006 Protein of unknown function (DUF1700)<br>Pfam-B_5023 (release 16.0). This family contains many hypothetical bacterial proteins and two putative membrane proteins (Swiss:Q6GFD0 and Swiss:Q6G806). . 
+PF08007 DUF1701; <br>Cupin superfamily protein. Pfam-B_5011 (release 16.0). This family contains many hypothetical proteins that belong to the cupin superfamily.. 
+PF08008 Viral cysteine rich<br>Pfam-B_4965 (release 16.0). Members of this family are polydna viral proteins that contain a cysteine rich motif  .  Some members of this family have  multiple copies of this domain.. 
+PF08009 TOM13; <br>CDP-alcohol phosphatidyltransferase 2. Pfam-B_51131 (release 16.0). This domain is found on CDP-alcohol phosphatidyltransferases. These enzymes catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.. 
+PF08010 Bacteriophage protein GP30.3<br>Pfam-B_5273 (release 16.0). Proteins in this family are bacteriophage GP30.3 proteins.  Their  function is poorly characterised   .. 
+PF08011 Protein of unknown function (DUF1703)<br>Pfam-B_5377 (release 16.0). This family contains many hypothetical bacterial proteins.  It has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches  . DUF1703 has the predicted secondary structure pattern of the restriction endonuclease-like fold core and contains an additional beta-strand at the C-terminus  .. 
+PF08012 Protein of unknown function (DUF1702)<br>Pfam-B_5312 (release 16.0). This family of proteins contains many bacterial proteins that are encoded by the UnbL gene.\.    The function of these proteins is unknown.. 
+PF08013 Tagatose 6 phosphate kinase<br>Pfam-B_5149 (release 16.0). Proteins in this family are tagatose 6 phosphate kinases. . 
+PF08014 Domain of unknown function (DUF1704)<br>Pfam-B_5490 (release 16.0). This family contains many hypothetical proteins.. 
+PF08015 Fungal mating-type pheromone<br>This family corresponds to mating-type pheromone proteins. The homobasidiomycetes, or mushroom fungi, have arguably the most complex mating system of all known organisms. Many species possess a mating system known as bifactorial incompatibility, where two unlinked loci control the mating -type of an individual incompatibility loci (the A and  B mating-type loci). Each A mating-type sublocus encodes a pair of divergently transcribed homeodomain transcription  factors while the genes responsible for B mating-type  activity encode lipopeptide pheromones and G-protein -coupled pheromone receptors  .. 
+PF08016 Polycystin cation channel<br>This family contains the cation channel region of PKD1 and PKD2 proteins.. 
+PF08017 Fibrinogen binding protein <br>Pfam-B_4323 (release 16.0). Proteins in this family bind to fibrinogen.  Members of this family includes the fibrinogen receptor, FbsA, (Swiss:Q8GIU3) which  mediates platelet aggregation  .. 
+PF08018 Frog antimicrobial peptide <br>This family includes antimicrobial peptides secreted from skins of frogs. The secretion of antimicrobial peptides from the skins of frogs plays an important role in the self defense of these frogs. Structural characterization of these peptides showed that they belonged to four known families: the brevinin-1 family, the esculentin-2 family, the ranatuerin-2 family and the temporin family  .. 
+PF08019 Domain of unknown function (DUF1705)<br>Pfam-B_1101 (release 16.0). Some members of this family are putative bacterial membrane proteins. This domain is found immediately N terminal to the sulfatase domain in many sulfatases.. 
+PF08020 Protein of unknown function (DUF1706)   <br>Pfam-B_5540 (release 16.0). This family contains many hypothetical proteins from bacteria  and yeast.. 
+PF08021 Siderophore-interacting FAD-binding domain<br>
+PF08022 FAD-binding domain<br>Pfam-B_728 (release 4.2). 
+PF08023 Frog antimicrobial peptide <br>This family consists of the major classes of antimicrobial peptides secreted from the skin of frogs that  protect the frogs against invading microbes. They are typically between 10-50 amino acids long and are derived from proteolytic cleavage of larger precursors. Major classes of peptides such  esculentin, gaegurin, brevinin, rugosin and ranatuerin are included in this family  .. 
+PF08024 Ant antimicrobial peptide<br>Short protein clustering. This family consists of the ponericin family of antimicrobial peptides isolated from predatory ant Pachycondyla goeldii. The ponericin peptides may adopt amphipathic alpha-helical structure in polar environments. In the ant colony, these peptides exhibit a defensive role against microbial pathogens  arising from prey introduction and/or ingestion  .. 
+PF08025 Spider antimicrobial peptide<br>Short protein clustering. This family includes antimicrobial peptides isolated from the crude venom of the wolf spider Oxyopes kitabensis. These peptides, known as oxyopinins, are the largest linear cationic amphipathic peptides chemically characterised and exhibit disrupting activities towards biological membranes  .. 
+PF08026 Bee antimicrobial peptide<br>Short protein clustering. This family consists of antimicrobial peptides produced by bees. These peptides have strong antimicrobial and some anti-fungal activity and has homology to abaecin which is the largest proline-rich antimicrobial peptide isolated from European bumblebee Bombus pascuorum  .. 
+PF08027 Albumin I<br>Pfam-B_100627 (release 16.0). The albumin I protein, a hormone-like peptide, stimulates kinase activity upon binding a membrane bound 43 kDa receptor. The structure of this domain reveals a knottin like fold, comprise of three beta strands  .. 
+PF08028 Acyl-CoA dehydrogenase, C-terminal domain<br>Pfam-B_8101 (release 16.0). 
+PF08029 HisG, C-terminal domain<br>Pfam-B_1550 (release 16.0). 
+PF08030 Ferric reductase NAD binding domain<br>
+PF08031 Berberine and berberine like <br>Pfam-B_649 (release 16.0). This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids.  They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine   .. 
+PF01238 Phosphomannose isomerase type I<br>This is a family of Phosphomannose isomerase type I enzymes (EC 5.3.1.8).. 
+PF08032 RNA 2'-O ribose methyltransferase substrate binding<br>Pfam-B_742 (release 16.0). This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.. 
+PF08033 Sec23/Sec24 beta-sandwich domain<br>
+PF08034 Trematode eggshell synthesis protein<br>This domain has been identified in a number of distantly related species  of trematodes. This protein domain is crucial for eggshell synthesis in trematodes (Ebersberger I).. 
+PF08035 Opioids neuropeptide<br>This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.. 
+PF08036 Diapausin family of antimicrobial peptide<br>Short protein clustering. This family consists of diapausin-related antimicrobial peptides. Diapause during periods of environmental adversity is an essential part of the life cycle of many organisms with the molecular basis being different among animals.  Diapause-specific peptides provide anti-fungal activity and act as N-type voltage-gated calcium channel blocker  .. 
+PF08037 Attractin family<br>Short protein clustering. This family consists of the attractin family of water-borne pheromone. Mate attraction in Aplysia  involves a long-distance water-borne signal in  the form of the attractin peptide, that is released  during egg laying. These peptides contain 6 conserved  cysteines and are folded into 2 antiparallel helices.  The second helix contains the IEECKTS sequence conserved in Aplysia attractins  .. 
+PF08038 TOM7 family<br>Short protein clustering. This family consists of TOM7 family of mitochondrial import receptors. TOM7 forms part of the translocase of the outer mitochondrial membrane (TOM) complex and it appears to function as a modulator of the dynamics of the mitochondrial protein transport machinery by promoting the dissociation of subunits of the outer membrane translocase  .. 
+PF08039 Mit_preoteolip; <br>Mitochondrial proteolipid. Short protein clustering. This family consists of proteins with similarity to the mitochondrial proteolipids. Mitochondrial proteolipid consists of about 60 amino acids residues and is about 6.8 kDa in size  .. 
+PF08040 MNLL subunit<br>Short protein clustering. This family consists of the MNLL subunits of NADH-ubiquinone  oxidoreductase complex. NADH-ubiquinone oxidoreductase is involved in the transfer of electrons from NADH to the electron  transport chain. This oxidation of NADH is coupled to proton  transfer across the membrane, generating a proton motive force  that is utilised for the synthesis of ATP  . MNLL subunit is   one of the many subunits found in the complex and it contains  a mitochondrial import sequence. However, the role of MNLL  subunit is unclear  .. 
+PF08041 PetM family of cytochrome b6f complex subunit 7<br>Short protein clustering. This family consists of the PetM family of cytochrome b6f complex subunit IV. The cytochrome b6f complex consists of 7 subunits and contains 2 beta hemes and 1 chlorophyll alpha per cytochrome f. It is highly active in transferring electrons from decylplastoquinol to oxidised plastocyanin  .. 
+PF08042 PqqA family<br>Short protein clustering. This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group  of many quinoproteins catalysing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are  unclear  .. 
+PF08043 Actin_bind_SAA; <br>The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD.  This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats.  Direct evidence for binding to and stabilising F-actin has been found   in the human protein Swiss:Q702N9. The homologues in mouse and chicken localise in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localise with Vinculin which is known to attach the actin to the cytoplasmic membrane  . It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC  . This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.. 
+PF08044 Domain of unknown function (DUF1707)<br>This domain is found in a variety of Actinomycetales proteins.  All of  the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function  of this domain.. 
+PF08045 Cell division control protein 14, SIN component<br>Cdc14 is a component of the septation initiation network (SIN) and is required for the localisation and activity of Sid1.  Sid1 is a protein kinase that localises asymmetrically to one spindle pole body (SPB) in anaphase disappears prior to cell separation    .. 
+PF08046 IlvGEDA operon leader peptide<br>Short protein clustering. This family consists of the leader peptides of ilvGEDA  operon. The expression of the ilvGEDA operon of E coli  K-12 is multivalently controlled by the three branched -chain amino acids. Regulation is thought to occur by  attenuation of transcription in response to the changing  levels of the cognate tRNAs. Transcription of this operon  is usually terminated at the end of the leader (regulatory)  region  .. 
+PF08047 Histidine operon leader peptide<br>Short protein clustering. This family consists of the leader peptide of  the histidine (his) operon. The his operon contains  all the genes necessary for histidine biosynthesis.  The region corresponding to the untranslated 5' end  of the transcript, named the his leader region, displays  the typical features of the T box transcriptional  attenuation mechanism which is involved in the regulation  of many amino acid biosynthetic operons  .. 
+PF08048 Tap RepA1 leader peptide<br>Short protein clustering. This family consists of the RepA1 leader peptides.  The frequency of replication of IncFII plasmid NR1 during the cell division cycle is regulated by the control of the synthesis of the plasmid-specific replication initiation protein (RepA1). When RepA1 is synthesised, it binds to the plasmid replication origin (ori) and effects the assembly of a replication complex composed of host proteins that mediate the replication of the plasmid  . The tap gene encodes a 24-amino acids protein. The translation of tap is required for translation of repA.. 
+PF08049 IlvB leader peptide<br>Short protein clustering. This family consists of the leader peptides of the ilvB operon. This region encodes a potential leader polypeptide containing 32 amino acids, 12 of which are the regulatory amino acids valine and leucine. A model for the multivalent regulation of this operon by valyl- and leucyl-tRNA is proposed on the basis of the mutually exclusive formation of five strong stem-and-loop structures in the leader mRNA  .. 
+PF08050 Tetracycline resistance leader peptide<br>Short protein clustering. This family consists of the tetracycline resistance leader peptide. The presence of 3 inverted repeats  which can form 2 different conformations of mRNA  suggests that the tetracycline resistance (TcR) region is regulated by a translational attenuation mechanism. A Rho-independent transcriptional terminator structure is present immediately after the translational stop codon  of the TET protein  .. 
+PF08051 Erythromycin resistance leader peptide<br>Short protein clustering. This family consists of erythromycin resistance gene leader peptides.  These leader peptides are involved in the translational attenuation of erythromycin resistance genes. Interestingly, the consensus sequence of peptides conferring erythromycin resistance is similar to that of the leader peptides, thus indicating that a similar type of interaction between the nascent peptide and antibiotics can occur in both cases  . This family also includes a small number of regions from within larger proteins from actinomycetes.. 
+PF08052 PyrBI operon leader peptide<br>Short protein clustering. This family consists of the pyrBI operon leader peptides. The expression of the pyrBI operon, which encodes the subunits of the pyrimidine biosynthetic enzyme aspartate transcarbamylase.  is regulated primarily through a UTP-sensitive transcriptional attenuation control mechanism.  In this mechanism, the concentration of UTP determines the extent of coupling between transcription and translation within the pyrBI leader region, hence determining the level of rho-independent transcriptional termination at an attenuator preceding the pyrB gene  .. 
+PF08053 Tryptophanese operon leader peptide<br>Short protein clustering. This family consists of the tryptophanese (tna) operon leader peptide. Tna catalyses the degradation of L-tryptophan to indole, pyruvate and ammonia, enabling the bacteria to utilise tryptophan as a source of carbon, nitrogen and energy.  The tna operon of E. coli contains two major structural genes, tnaA and tnaB. Preceding tnaA in the tna operon is a 319 -nucleotide transcribed regulatory region that contains the coding region for a 24-residue leader peptide, TnaC. The RNA sequence in the vicinity of the tnaC stop codon is rich in Cytidylate residues which is required for efficient Rho -dependent termination in the leader region of the tna operon  .. 
+PF08054 Leucine operon leader peptide<br>Short protein clustering. This family consists of the leucine operon leader peptide. The leucine operon is involved in the control of the biosynthesis of leucine. Four adjacent leucine codons within the leucine leader RNA are critically important in transcription attenuation-mediated control of leucine operon expression in bacteria. The leader RNA contains translational start and stop signals, a cluster of four leucine codons and overlapping regions of dyad symmetry that are capable of forming stem-and-loop structures  .. 
+PF08055 Tryptophan leader peptide<br>Short protein clustering. This family consists of the tryptophan (trp) leader peptides. Tryptophan accumulation is the principal event resulting in downregulation of transcription of the structural genes of the trp operon. The leader peptide of the trp operon forms mutually exclusive secondary structures that would either result in the termination of transcription of the trp operon when tryptophan is in plentiful supply or vice versa  .. 
+PF08056 Tryptophan operon leader peptide<br>Short protein clustering. This family consists of the tryptophan operon  leader peptides. The tryptophan operon is regulated  by transcription attenuation in response to changes  in the level of tryptophan. The transcript of the  leader peptide can adopt alternative mutually-exclusive  secondary structures that would either result in  termination of transcription of the tryptophan structural  genes or in transcription of the entire operon  .. 
+PF08057 Erythromycin resistance leader peptide<br>Short protein clustering. This family consists of erythromycin resistance gene leader peptides.  These leader peptides are involved in the transcriptional attenuation control of the synthesis of the macrolide-lincosamide -streptogramin B resistance protein. It acts as a transcriptional attenuator, in contrast to other inducible erm genes. The mRNA leader sequence can fold in either of two mutually exclusive conformations, one of which is postulated to form in the absence of induction, and to contain two rho factor-independent terminators.  .. 
+PF08058 Nuclear pore complex component<br>Wood V, Mistry J, Novatchkova M. Proteins containing this domain are components of the  nuclear pore complex  .  One member of this family  is Nucleoporin POM34 (Swiss: Q12445) which is thought to have a role in  anchoring peripheral Nups into the pore and mediating pore formation  .. 
+PF08059 SEP domain<br>Pfam-B_1894 (release 16.0). The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47.  In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L  .  Most SEP domains are succeeded closely by a UBX domain  .. 
+PF08060 NOSIC (NUC001) domain<br>This is the central domain in Nop56/SIK1-like proteins  .. 
+PF08061 P68HR (NUC004) repeat<br>This short region is found in two copies in p68-like RNA helicases  .. 
+PF08062 P120R (NUC006) repeat<br>This characteristic repeat of proliferating cell nuclear antigen P120 is found in three copies  .. 
+PF08063 PADR1 (NUC008) domain<br>This domain is found in poly(ADP-ribose)-synthetases  . The function of this domain is unknown.. 
+PF08064 UME (NUC010) domain<br>This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1  .. 
+PF08065 K167R (NUC007) repeat<br>This family represents the K167/Chmadrin repeat  . The function of this repeat is unknown.. 
+PF08066 PMC2NT (NUC016) domain<br>This domain is found at the N-terminus of 3'-5' exonucleases with HRDC domains, and also in putative exosome components  .. 
+PF08067 ROKNT (NUC014) domain<br>This presumed domain is found at the N-terminus of RNP K-like proteins that also contains KH domains Pfam:PF00013  .. 
+PF08068 DKCLD (NUC011) domain<br>This is a TruB_N/PUA domain associated N-terminal domain of Dyskerin-like proteins  .. 
+PF08069 Ribosomal S13/S15 N-terminal domain<br>This domain is found at the N-terminus of ribosomal S13 and S15 proteins.\.      This domain is also identified as NUC021  .. 
+PF08070 DTHCT (NUC029) region<br>The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins  . This region is composed of quite low complexity sequence.. 
+PF08071 RS4NT (NUC023) domain<br>This is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains  .. 
+PF08072 BDHCT (NUC031) domain<br>This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily  .. 
+PF08073 CHDNT (NUC034) domain<br>The CHDNT domain is found in PHD/RING finger and chromo domain-associated helicases  .. 
+PF08074 CHDCT2 (NUC038) domain<br>The CHDCT2 C-terminal domain is found in PHD/RING finger and chromo domain-associated CHD-like helicases  .. 
+PF08075 NOPS (NUC059) domain<br>This domain is found at the C-terminus of NONA and PSP1 proteins  adjacent to 1 or 2 Pfam:PF00076 domains  .. 
+PF08076 Tetracycline resistance determinant leader peptide<br>Short protein clustering. This family consists of the tetracycline resistance  determinant tet(M) leader peptides. A short open  reading frame corresponding to a 28 amino acid peptide  which contain a number of inverted repeat sequences was  found immediately upstream of the tet(M). Transcriptional  analyses has found that expression of tet(M) resulted from an  extension of a small transcript representing the upstream  leader region into the resistance determinant. Thus this  leader sequence is responsible for transcriptional attenuation  and thus regulation of the transcription of tet(M)  .. 
+PF08077 Chloramphenicol resistance gene leader peptide<br>Short protein clustering. This family consists of chloramphenicol (Cm) resistance  gene leader peptides. Inducible resistance to Cm in both  Gram positive and Gram negative bacteria is controlled  by translation attenuation. In translation attenuation,  the ribosome-binding-site (RBS) for the resistance  determinant is sequestered in a secondary structure domain  within the mRNA. Preceding the secondary structure is a  short, translated ORF termed the leader. Ribosome stalling  in the leader causes the destabilization of the downstream  secondary structure, allowing initiation of translation  of the Cm resistance gene  .. 
+PF08078 PsaX family<br>Short protein clustering. This family consists of the PsaX family of photosystem I (PSI) protein subunits.\.       PSI is a large multi-subunit pigment protein complex embedded in the thylakoid membranes of green plants and cyanobacteria. PsaX is one of the 12 protein subunits found in PSI and these subunits are arranged as monomers or trimers within the membrane as shown by the structure of the trimeric complex from Synechococcus elongatus  .. 
+PF08079 Ribosomal L30 N-terminal domain<br>This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018  .. 
+PF08080 RNPHF zinc finger<br>This domain is a putative zinc-binding domain (CHHC motif) in RNP H and F.  The domain is often associated with Pfam:PF00076.. 
+PF08081 RBM1CTR (NUC064) family<br>This C-terminal region is found in RBM1-like RNA binding hnRNPs  .. 
+PF08082 PRO8NT (NUC069), PrP8 N-terminal domain<br>The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family  . The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region  .. 
+PF08083 PROCN (NUC071) domain<br>The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family  .. 
+PF08084 PROCT (NUC072) domain<br>The PROCT domain is the C-terminal domain in pre-mRNA splicing factors of PRO8 family  .. 
+PF08085 Entericidin EcnA/B family<br>Short protein clustering. This family consists of the entericidin antidote/toxin peptides. The entericidin locus is activated in stationary phase under high osmolarity conditions by rho-S and simultaneously repressed by the osmoregulatory EnvZ/OmpR signal transduction pathway. The entericidin locus encodes tandem paralogous genes (ecnAB) and directs the synthesis of two small cell-envelope lipoproteins which can maintain plasmids in bacterial population by means of post-segregational killing  .. 
+PF08086 Ergtoxin family<br>Short protein clustering. This family consists of ergtoxin peptides which are toxins secreted by the scorpions.\.  The ergtoxins are capable of blocking the function of K+ channels. More than 100 ergtoxins have been found from scorpion venoms and they have been classified into three subfamilies according to their primary structures  .. 
+PF08087 Conotoxin O-superfamily<br>Short protein clustering. This family consists of members of the conotoxin  O-superfamily. The O-superfamily of conotoxins  consists of 3 groups of Conus peptides that belong  to the same structural group. These 3 groups differ  in their pharmacological properties: the w-conotoxins  which inhibit calcium channels, the delta-conotoxins  which slow down the inactivation rate of voltage -sensitive sodium channels and the muO-conotoxins block  the voltage sensitive sodium currents  .. 
+PF08088 Conotoxin I-superfamily<br>Short protein clustering. This family consists of the I-superfamily of  conotoxins. This is a new class of peptides in  the venom of some Conus species. These toxins  are characterised by four disulfide bridges and  inhibit of modify ion channels of nerve cells.  The I-superfamily conotoxins is found in five or  six major clades of cone snails and could possible  be found in many more species  .. 
+PF08089 Huwentoxin-II family<br>Short protein clustering. This family consists of the huwentoxin-II (HWTX-II)  family of toxins secreted by spiders. These toxins are found in venom that secreted from the bird spider  Selenocosmia huwena Wang. The HWTX-II adopts a novel  scaffold different from the ICK motif that is found in  other huwentoxins. HWTX-II consists of 37 amino acids  residues including six cysteines involved in three  disulfide bridges  .. 
+PF08090 Enterotoxin_ST; <br>Heat stable E.coli enterotoxin 1. Short protein clustering. Heat-stable toxin 1 of entero-aggregative E.coli (EAST1) is a small toxin. It is not, however, solely associated with entero-aggregative E.coli but also with many other diarrhoaeic E. coli families. Some studies have established the role of EAST1 in some human outbreaks of diarrhoea. Isolates from farm animals have been shown to carry the astA gene coding for EAST1. However, the relation between the presence of EAST1 and disease is not conclusive  .. 
+PF08091 Spider insecticidal peptide<br>Short protein clustering. This family consists of insecticidal peptides isolated  from venom of spiders of Aptostichus schlingeri and  Calisoga sp. Nine insecticidal peptides were isolated  from the venom of the Aptostichus schlingeri spider and  seven of these toxins cause flaccid paralysis to insect  larvae within 10 min of injection. However, all nine  peptides were lethal within 24 hours  .. 
+PF08092 Magi peptide toxin family <br>Short protein clustering. This family consists of Magi peptide toxins (Magi 1, 2 and 5) isolated from the venom of Hexathelidae spider. These insecticidal peptide toxins bind to sodium channels and induce flaccid paralysis when injected into lepidopteran larvae. However, these peptides are not toxic to mice when injected intracranially at 20 pmol/g  .. 
+PF08093 Magi 5 toxic peptide family<br>Short protein clustering. This family consists of toxic peptides (Magi 5) found in the venom of the Hexathelidae spider. Magi 5 is the first spider toxin with binding affinity to site 4 of a mammalian sodium channel and the toxin has an insecticidal effect on larvae, causing paralysis when injected into the larvae  .. 
+PF08094 Conotoxin TVIIA/GS family<br>Short protein clustering. This family consists of conotoxins isolated from the venom  of cone snail Conus tulipa and Conus geographus. Conotoxin  TVIIA, isolated from Conus tulipa displays little sequence  homology with other well-characterised pharmacological  classes of peptides, but displays similarity with conotoxin GS, a peptide from Conus geographus. Both these peptides  block skeletal muscle sodium channels and also share  several biochemical features and represent a distinct subgroup  of the four-loop conotoxins  .. 
+PF08095 Hefutoxin family<br>Short protein clustering. This family consists of the hefutoxins that are found  in the venom of the scorpion Heterometrus fulvipes.  These toxins, kappa-hefutoxin1 and kappa-hefutoxin2,  exhibit no homology to any known toxins. The hefutoxins  are potassium channel toxins  .. 
+PF08096 Bombolitin family<br>Short protein clustering. This family consists of the bombolitin peptides that  are found in the venom of the bumblebee Megabombus  pennsylvanicus. Bombolitins are structurally and  functionally very similar. They lyse erythrocytes and  liposomes, release histamine from rat peritoneal mast  cells, and stimulate phospholipase A2 from different  sources  .. 
+PF08097 Conotoxin T-superfamily<br>Short protein clustering. This family consists of the T-superfamily of conotoxins.  Eight different T-superfamily peptides from five Conus species were identified. These peptides share a consensus signal sequence, and a conserved arrangement of cysteine residues. T-superfamily peptides were found expressed in venom ducts of all major feeding types of Conus, suggesting that the T-superfamily is a large and diverse group of peptides, widely distributed in the 500 different Conus species  .. 
+PF08098 Anemonia sulcata toxin III family<br>Short protein clustering. This family consists of the Anemonia sulcata toxin III  (ATX III) neurotoxin family. ATX III is a neurotoxin  that is produced by sea anemone; it adopts a compact  structure containing four reverse turns and two other  chain reversals, but no regular alpha-helix or beta-sheet.  A hydrophobic patch found on the surface of the peptide may  constitute part of the sodium channel binding surface  .. 
+PF08099 Scorpion calcine family<br>Short protein clustering. This family consists of the calcine family of scorpion  toxins. The calcine family consists of Maurocalcine and  Imperatoxin. These toxins have been shown to be potent  effector of ryanodyne-sensitive calcium channel from  skeletal muscles. These toxins are thus useful for  dihydropyridine receptor/ryanodyne receptor interaction  studies [1,2].. 
+PF08100 Dimerisation domain<br>Pfam-B_455 (Release 16.0). This domain is found at the N-terminus of a variety of plant O-methyltransferases. It has been shown to mediate dimerisation of these proteins  .. 
+PF08101 Domain of unknown function (DUF1708)<br>Mistry J, Wood V, Novatchkova M. This is a yeast domain of unknown function.. 
+PF08102 Scorpion antimicrobial peptide <br>Short protein clustering. This family consists of antimicrobial peptides secreted by scorpions. Novel antimicrobial peptides have been isolated from scorpions, namely the opistoporin   and the pandinin  . These peptides form essentially helical structures and demonstrate high antimicrobial activity against Gram-negative and Gram-positive bacteria respectively.. 
+PF08103 Uperin family<br>Short protein clustering. This family consists of the uperin family of antimicrobial peptides.  Uperin is a wide-spectrum antibiotic peptide isolated from the Australian toadlet, Uperoleia mjobergii. Being only 17 amino acid residues long, it is smaller than most other wide-spectrum antibiotic peptides isolated from amphibians. Uperin adopts a well-defined amphipathic alpha-helix with distinct hydrophilic and hydrophobic faces  .. 
+PF08104 Ponericin L family<br>Short protein clustering. This family consists of the ponericin L family of antimicrobial peptides that are isolated from the venom of the predatory ant Pachycondyla goeldii. Ponericin L family shares similarities with dermaseptins. Ponericin L may adopt an amphipathic alpha-helical structure in polar environments and these peptides exhibit a defensive role against microbial pathogens arising from prey introduction and/or ingestion  .. 
+PF08105 Metchnikowin family<br>Short protein clustering. This family consists of the metchnikowin family of antimicrobial peptides from Drosophila.\.       metchnikowin is a proline-rich peptide whose expression is immune-inducible. Induction of the metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product. The metchnikowin peptide is unique among the Drosophila antimicrobial peptides in that it is active against both bacteria and fungi  .. 
+PF08106 Formaecin family<br>Short protein clustering. This family consists of the formaecin family of  antimicrobial peptides isolated from the bulldog  ant Myrmecia gulosa in response to bacterial  infection. Formaecins are inducible peptide  antibiotics and are active against growing  Escherichia coli but were inactive against other  Gram-negative and Gram-positive bacteria. Formaecin peptides are 16 amino acids long, are rich in proline  and have N-acetylgalactosamine O-linked to a conserved  threonine  .. 
+PF08107 Pleurocidin family<br>Short protein clustering. This family consists of the pleurocidin family of antimicrobial peptides. Pleurocidins are found in the skin mucous secretions of the winter flounder (Pleuronectes americanus) and these peptides exhibit antimicrobial activity against Escherichia coli. Pleurocidin is predicted to assume an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defense  .. 
+PF08108 Halocidin family<br>Short protein clustering. This family consists of the halocidin family of antimicrobial peptides. Halocidins are isolated from the haemocytes of the tunicate, Halocynthia aurantium. They are dimeric in structures which are found via a disulfide linkage between cysteines of two different- sized monomers. Halocidins have been shown to have strong antimicrobial activities against a wide variety of pathogenic bacteria and could be ideal candidates as peptide antibiotics against multidrug-resistant bacteria  .. 
+PF08109 Lactocin 705 family<br>Short protein clustering. This family consists of lactocin 705 which is a bacteriocin  produced by Lactobacillus casei CRL 705. Lactocin 705 is a class IIb bacteriocin, whose activity depends upon the  complementation of two peptides (705-alpha and 705-beta) of  33 amino acid residues each. Lactocin 705 is active against  several Gram-positive bacteria, including food-borne pathogens  and is a good candidate to be used for biopreservation of  fermented meats  .. 
+PF08110 Ocellatin family<br>Short protein clustering. This family consists of the ocellatin family of antimicrobial peptides. Ocellatins are produced from the electrical-stimulated skin secretions of the South American frog, Leptodactylus ocellatus.  The family consists of three structurally related peptides, ocellatin 1, ocellatin 2 and ocellatin 3.  These peptides present hemolytic activity against human erythrocytes and are also active against Escherichia coli  .. 
+PF08111 Pea-VEAacid family<br>Short protein clustering. This family consists of the PEA-VEAacid neuropeptides  family. These neuropeptides are isolated from the  abdominal perisympathetic organs of the American cockroach.  These peptides are found together with Pea-YLS-amide and Pea-SKNacid, giving a unique neuropeptide pattern in abdominal  perisympathetic organs. The functions of these neuropeptides  are unknown  .. 
+PF08112 ATP synthase epsilon subunit<br>Short protein clustering. This family consists of epsilon subunits of the ATP  synthase. The ATP synthase complex is composed of an  oligomeric transmembrane sector (CF0), and a catalytic  core (CF1). CF1 is composed of 5 subunits, of which  the epsilon subunit functions as a potent inhibitor of  ATPase activity in both soluble and bound CF1. Only  when the epsilon inhibition is disabled is high  ATPase activity detected in ATPase  . 
+PF08113 Cytochrome c oxidase subunit IIa family<br>Short protein clustering. This family consists of the cytochrome c oxidase subunit IIa family.  The bax-type cytochrome c oxidase from Thermus thermophilus is known as a two subunit enzyme. From its crystal structure, it was discovered that an additional transmembrane helix 'subunit IIa' spans the membrane.  This subunit consists of 34 residues forming one helix across the membrane. The presence of this subunit seems to be important for the function of cytochrome c oxidases  .. 
+PF08114 ATPase proteolipid family<br>Short protein clustering. This family consists of small proteolipids associated with the plasma membrane H+ ATPase. Two proteolipids (PMP1 and PMP2) are associated with the ATPase and both genes are similarly expressed in the wild-type strain of yeast with no modification of the level of transcription of one PMP gene is detected in a strain deleted of the other. Though both proteolipids show similarity with other small proteolipids associated with other cation -transporting ATPases, their functions remain unclear  .. 
+PF08115 SFI toxin family<br>Short protein clustering. This family consists of the SFI family of spider toxins. This family of toxins might share structural, evolutionary and functional relationships with other small, highly structurally constrained spider neurotoxins. These toxins are highly selective agonists/antagonists of different voltage-dependent calcium channels and are extremely valuable reagents in the analysis of neuromuscular function  .. 
+PF08116 PhTx neurotoxin family<br>Short protein clustering. This family consists of PhTx insecticidal neurotoxins that are found in the venom of Brazilian, Phoneutria nigriventer. The venom of the Phoneutria nigrivente contains numerous neurotoxic polypeptides of 30-140 amino acids which exert a range of biological effects.  While some of these neurotoxins are lethal to mice after intracerebroventricular injections, others are extremely toxic to insects of the orders Diptera and Dictyoptera but had much weaker toxic effects on mice  .. 
+PF08117 Ptu family<br>Short protein clustering. This family consists of toxic peptides that are  isolated from the saliva of assassin bugs. The  saliva contains a complex mixture of proteins  that are used by the bug either to immobilise  the prey or to digest it. One of the proteins (Ptu1)  has been purified and shown to block reversibly the  N-type calcium channels and to be less specific for  the L- and P/Q- type calcium channels expressed in  BHK cells  .. 
+PF08118 Yeast mitochondrial distribution and morphology (MDM) proteins <br>Pfam-B_37122 (release 16.0). Proteins in this family are yeast mitochondrial inner membrane proteins MDM31 and MDM32.\.       These proteins are required for the maintenance of mitochondrial morphology, and the stability of mitochondrial DNA  .. 
+PF08119 Scorpion acidic alpha-KTx toxin family<br>Short protein clustering. This family consists of acidic alpha-KTx short chain scorpion toxins. These toxins named parabutoxins, block voltage-gated K channels and have extremely low pI values. Furthermore, they lack the crucial pore-plugging lysine. In addition, the second important residue of the dyad, the hydrophobic residue (Phe or Tyr) is also missing  .. 
+PF08120 Tamulustoxin family<br>Short protein clustering. This family consists of the tamulustoxins which are  found in the venom of the Indian red scorpion (Mesobuthus  tamulus). Tamulustoxin shares no similarity with other  scorpion venom toxins, although the positions of its six  cysteine residues suggest that it shares the same  structural scaffold. Tamulustoxin acts as a potassium channel  blocker  .. 
+PF08121 Waglerin family<br>Short protein clustering. This family consists of the lethal peptides (waglerins)  that are found in the venom of Trimeresurus wagleri.  Waglerins are 22-24 residue lethal peptides and are  competitive antagonist of the muscle nicotinic receptor  (nAChR). Waglerin-1 possesses a distinctive selectivity  for the alpha-epsilon interface binding site of the mouse  nAChR  .. 
+PF08122 NADH-ubiquinone oxidoreductase B12 subunit family<br>Short protein clustering. This family consists of the NADH-ubiquinone  oxidoreductase B12 subunit proteins. NADH is the  central source of electrons in the mitochondrial  and bacterial respiration. NADH-ubiquinone  oxidoreductase is involved in the transfer of  electrons from NADH to the electron transport  chain. This oxidation of NADH is coupled to  proton transfer across the membrane, generating  a proton motive force that is utilised for the  synthesis of ATP. The function of this subunit is unclear  .. 
+PF08123 Histone methylation protein DOT1 <br>Pfam-B_12064 (release 16.0). The DOT1 domain regulates gene expression by methylating histone H3  . H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast  .. 
+PF08124 Polysaccharide lyase family 8, N terminal alpha-helical domain<br>Pfam-B_2438 (release 16.0). This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.. 
+PF08125 Mannitol dehydrogenase C-terminal domain<br>
+PF08126 Propeptide_C25<br>This is found at the N terminal end of some of the members of the C25 peptidase family (PF01364).  Little is known about the function of this motif.. 
+PF08127 Peptidase family C1 propeptide<br>This motif is found at the N terminal of some members of the Peptidase_C1 family (Pfam:PF00112) and is involved in activation of this peptidase  .. 
+PF08129 Alpha/beta enterocin family<br>Short protein clustering. This family consists of the alpha and beta enterocins and  lactococcin G peptides. These peptides have some antimicrobial  properties; they inhibit the growth of Enterococcus spp. and a  few other gram-positive bacteria. These peptides act as pore- forming toxins that create cell membrane channels through a  barrel-stave mechanism and thus produce an ionic imbalance in  the cell. These family of antimicrobial peptides belong to the  class II group of bacteriocin  .. 
+PF08130 Type A lantibiotic family<br>Short protein clustering. This family consists of the type A lantibiotic peptides. Both Pep5  and epicidin-280 are ribosomally-synthesised antimicrobial peptides  produced by Gram-positive bacteria that are characterised by the  presence of lanthionine and/or methyllanthionine residues. The  lantibiotics family has a highly specific activity against multi- drug resistant bacteria and has potential to be utilised in a wide range of medical applications [1,2].. 
+PF08131 Defensin-like peptide family<br>Short protein clustering. This family consists of the defensin-like peptides (DLPs) isolated from platypus venom. These DLPs show similar three-dimensional fold to that of beta-defensin-12 and sodium-channel neurotoxin Shl. However the side chains known to be functionally important to beta-defensin-12 and Shl are not conserved in DLPs. This suggests a different biological function. Consistent with this contention, DLPs have been shown to possess no anti-microbial properties and have no observable activity on rat dorsal-root-ganglion sodium-channel currents  .. 
+PF08132 S-adenosyl-l-methionine decarboxylase leader peptide<br>Short protein clustering. This family consists of the S-adenosyl-l-methionine decarboxylase (AdoMetDC) leader peptides. AdoMetDC is a key regulatory enzymes in the biosynthesis of polyamines. All expressed plant AdoMetDC mRNA 5' leader sequences contain a highly conserved pair of overlapping upstream ORFs (uORFs) that overlap by one base. Sequences of the small uORFs are highly conserved between monocot, dicot and gymnosperm AdoMetDC mRNA species, suggesting a translational regulatory mechanism  .. 
+PF08133 Anticodon nuclease activator family<br>Short protein clustering. This family consists of the anticodon nuclease activator proteins.  Pre-existing host tRNAs are reprocessed during bacteriophage T4 infection of certain Escherichia coli strains. In this pathway, tRNA(Lys) is cleaved 5' by the anticodon nuclease to the wobble base and is later restored in polynucleotide kinase and RNA ligase reactions  .. 
+PF08134 cIII protein family<br>Short protein clustering. This family consists of the cIII family of  regulatory proteins. The lambda CIII protein  has 54 amino acids and it forms an amphipathic  helix within its amino acid sequence. Lambda  cIII stabilises the lambda cII protein and the  host sigma factor 32, responsible for transcribing  genes of the heat shock regulon  . . 
+PF08135 Major transforming protein E5 family<br>Short protein clustering. This family consists of the major transforming proteins (E5)  of the bovine papilloma virus (BPV). The equine sarcoid is  one of the most common dermatological lesion in equids. It is  a benign, locally invasive dermal fibroblastic lesion and  studies have shown an association of the lesions with BPV. E5  is a short hydrophobic membrane protein localising to the Golgi  apparatus and other intracellular membranes. It binds to and  constitutively activates the platelet-derived growth factor-beta  in transformed cells. This stimulation activates a receptor  signaling cascade which results in an intracellular growth  stimulatory signal  .. 
+PF08136 30S ribosomal protein subunit S22 family<br>Short protein clustering. This family consists of the 30S ribosomal proteins subunit  S22 polypeptides. This polypeptide is 47 amino acids in length  and has a molecular weight of about 5 kDa. The S22 subunit is a  component of the stationary-phase-specific ribosomal protein and  is assembled in the ribosomal particles in the stationary phase.  This subunit along with other stationary-phase-specific ribosomal  proteins result in compositional changes of ribosomes during the  stationary phase. The significance of this change is not clear as  yet  .. 
+PF08137 DVL family<br>Short protein clustering. This family consists of the DVL family of proteins.  In a gain-of-function genetic screen for genes that influence fruit development in Arabidopsis, DEVIL (DVL) gene was identified. DVL is a small protein and overexpression of the protein results in pleiotropic phenotypes featured by shortened stature, rounder rosette leaves, clustered inflorescences, shortened pedicles, and siliques with pronged tips. DVL family is a novel class of small polypeptides and the overexpression phenotypes suggest that these polypeptides may have a role in plant development  .. 
+PF08138 Sex peptide (SP) family<br>Short protein clustering. This family consists of Sex Peptides (SP) that are found in Drosophila. On mating, Drosophila females decreases her remating rate and increases her egg-laying rate due, in part, to the transfer of SP from the male to the female. SP are found in seminal fluids transferred from the male to the female during mating. The male seminal fluid proteins are referred to as accessory gland proteins (Acps). The SP is one of the most interesting Acps and plays an important role in reproduction  .. 
+PF08139 VirB;<br>Prokaryotic membrane lipoprotein lipid attachment site. Short protein clustering. In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached  .. 
+PF08140 Crustacean cuticle protein repeat<br>Short protein clustering. This family consists of the cuticle proteins from the Cancer  pagurus and the Homarus americanus. These proteins are isolated  from the calcified regions of the crustacean and they contain two  copies of an 18 residue sequence motif, which thus far has been  found only in crustacean calcified exoskeletons  .. 
+PF08141 Small acid-soluble spore protein H family<br>Short protein clustering. This family consists of the small acid-soluble spore proteins  (SASP) of the H type (sspH). SspH are unique to spores of Bacillus  subtilis and are expressed only in the forespore compartment  during sporulation of this organism. The sspH genes are  monocistronic and are recognised by the forespore-specific  sigma factor for RNA polymerase - sigma-G. The specific role  of this protein is unclear but is thought to play a role in  sporulation under conditions different from that of the common laboratory tests of spore properties  .. 
+PF08142 AARP2CN (NUC121) domain<br>This domain is the central domain of AARP2.  It is weakly similar to  the GTP-binding domain of elongation factor TU  .. 
+PF08143 CBFNT (NUC161) domain<br>This N terminal domain is found in proteins of CARG-binding factor A-like proteins  .. 
+PF08144 CPL (NUC119) domain<br>This C terminal domain is fund in Penguin-like proteins associated  with Pumilio like repeats  .. 
+PF08145 BOP1NT (NUC169) domain<br>This N terminal domain is found in BOP1-like WD40 proteins  .. 
+PF08146 BP28CT (NUC211) domain<br>This C terminal domain is found in BAP28-like nucleolar proteins  .. 
+PF08147 DBP10CT (NUC160) domain<br>This C terminal domain is found in the Dbp10p subfamily of  hypothetical RNA helicases  . . 
+PF08148 DSHCT (NUC185) domain<br>This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases  .. 
+PF08149 BING4CT (NUC141) domain<br>This C terminal domain is found in the BING4 family of nucleolar  WD40 repeat proteins  .. 
+PF08150 FerB (NUC096) domain<br>This is central domain B in proteins of the Ferlin family  .. 
+PF08151 FerI (NUC094) domain<br>This domain is present in proteins of the Ferlin family.  It is often located between two C2 domains  .. 
+PF08152 GUCT (NUC152) domain<br>This is the C terminal domain found in the RNA helicase II / Gu  protein family  .. 
+PF08153 NGP1NT (NUC091) domain<br>This N terminal domain is found in a subfamily of hypothetical nucleolar GTP-binding proteins similar to human NGP1  .. 
+PF08154 NLE (NUC135) domain<br>This domain is located N terminal to WD40 repeats.  It is found in  the microtubule-associated protein Swiss:Q12024  . . 
+PF08155 NOGCT (NUC087) domain<br>This C terminal domain is found in the NOG subfamily of nucleolar GTP-binding proteins  .. 
+PF08156 NOP5NT (NUC127) domain<br>This N terminal domain is found in RNA-binding proteins of the  NOP5 family  .. 
+PF08157 NUC129 domain<br>This C terminal domain is found in a novel family of hypothetical nucleolar proteins  .. 
+PF08158 NUC130/3NT domain<br>This N terminal domain is found in a novel nucleolar protein family  .. 
+PF08159 NUC153 domain<br>This small domain is found in a a novel nucleolar family  . . 
+PF08161 NUC173 domain<br>This is the central domain of of novel family of hypothetical  nucleolar proteins  .. 
+PF08163 NUC194 domain<br>This is domain B in the catalytic subunit of DNA-dependent protein kinases.. 
+PF08164 Apoptosis-antagonizing transcription factor, C-terminal<br>This C terminal domain is found in traube proteins  . This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.. 
+PF08165 FerA (NUC095) domain<br>This is central domain A in proteins of the Ferlin family  .. 
+PF08166 NUC202 domain<br>This domain is found in a novel family of nucleolar proteins  .. 
+PF08167 NUC201;<br>rRNA processing/ribosome biogenesis. Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly [1,2]. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion  . This family is usually associated with NUC202, Pfam:PF08166.. 
+PF08168 NUC205 domain<br>This domain is found in a novel family of nucleolar proteins  .. 
+PF08169 RBB1NT (NUC162) domain<br>This domain is found N terminal to the ARID/BRIGHT domain in   DNA-binding proteins of the Retinoblastoma-binding protein 1 family  .. 
+PF08170 POPLD (NUC188) domain<br>This domain is found in POP1-like nucleolar proteins  .. 
+PF08171 Mad3_like; <br>Mad3/BUB1 homology region 2. Pfam-B_113144 (release 16.0). This domain is found in checkpoint proteins which are involved in cell division.  This region has been shown to be necessary and sufficient for the binding of MAD3 to BUB3 in Saccharomyces cerevisiae. This domain is present in BUB1 which also binds BUB3  .. 
+PF08172 CASP C terminal<br>Pfam-B_7701 (release 16.0). This domain is the C-terminal region of the CASP family of proteins.  It is a Golgi membrane protein which is thought to have a role in vesicle transport  .. 
+PF08173 Membrane bound YbgT-like protein<br>Short protein clustering. This family contains a set of membrane proteins, typically 33 amino acids long.  The family has no known function, but the protein is found  in the operon CydAB in E. coli. Members have a consensus motif (MWYFXW)  which is rich in aromatic residues.  The protein forms a single membrane-spanning helix.  This family seems to be restricted to Proteobacteria  .. 
+PF08174 DUF1709;<br>Cell division protein anillin. Pfam-B_55293 (release 16.0). Anillin is a protein involved in septin organisation during cell division.\.     It is an actin binding protein that is localised to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis  .. 
+PF08175 Small acid-soluble spore protein O family<br>Short protein clustering. This family consists of the small acid-soluble spore proteins  (SASP) O type (sspO). SspO (originally cotK) are unique to  the spores of Bacillus subtilis and are expressed only in the  forespore compartment of sporulating cells of this organism.  The sspO is the first gene in a likely operon with sspP and  transcription of this gene is primarily by RNA polymerase with  the forespore-specific sigma factor, sigma-G. Mutation deleting sspO causes the loss of the SspO from the forespore but had no  discernible effect on sporulation, spore properties or spore  germination  .. 
+PF08176 Small acid-soluble spore protein K family<br>Short protein clustering. This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism.  The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination  .. 
+PF08177 Small acid-soluble spore protein N family<br>Short protein clustering. This family consists of the small acid-soluble spore protein  (SASP) N type (sspN). SspN is a 48 residues protein that is  expressed only in the forespore compartment of sporulating  Bacillus subtilis. The sspN gene is recognised equally by both  sigma-G and sigma-F. The role of SspN is still not well-defined  .. 
+PF08178 GnsA/GnsB family<br>Short protein clustering. This family consists of the GnsA/GnsB family. GnsA and GnsB  are multicopy suppressors of the secG null mutation. These  proteins participate in the synthesis of phospholipids,  suggesting the functional relationship between SecG and  membrane phospholipids. Overexpression of gnsA and gnsB causes  a remarkable increase in the unsaturated fatty acid content.  However, the gnsA-gnsB double null mutant exhibits no effect.  Both proteins are predicted to possess a helix-turn-helix  structure  .. 
+PF08179 Small acid-soluble spore protein P family<br>Short protein clustering. This family consists of the small acid-soluble spore proteins (SASP) P type (sspP). sspP is expressed only in the forespore compartment of the sporulating cell. sspP is also expressed under sigma-G control from the same promoter as sspO. Mutations deleting sspP causes no discernible effect on sporulation, spore properties or spore germination  .. 
+PF08180 B melanoma antigen family<br>Short protein clustering. This family consists of the B melanoma antigen (BAGE) peptides.  The BAGE gene encodes a human tumour antigen that is recognised  by a cytolytic T lymphocyte. BAGE genes are expressed in melanomas,  bladder and lung carcinomas and in a few tumours of other histological  types  .. 
+PF08181 DegQ (SacQ) family<br>Short protein clustering. This family consists of the DegQ (formerly sacQ) regulatory peptides. The DegQ family of peptides control the rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis. DegQ is 46 amino acids long and activates the synthesis of degradative enzymes.  The expression of this peptide was shown to be subjected both to catabolite repression and DegS-DegU-mediated control. Thus allowing an increase in the rate of synthesis of degQ under conditions of nitrogen starvation  .. 
+PF08182 Pedibin/Hym-346 family<br>Short protein clustering. This family consists of the pedibin and Hym-346 signaling peptides.  These two peptides have been isolated from Hydra vulgaris and Hydra magnipapillata. Experiments have indicated that both cause a reduction in the positional value gradient, the principle patterning process governing the maintenance of form in the adult hydra. The peptides cause an increase in the rate of foot regeneration following bisection of the body column. Thus both play important signaling roles in patterning processes in cnidaria and maybe in more complex metazoans  .. 
+PF08183 Stage V sporulation protein family<br>Short protein clustering. This family consists of the stage V sporulation (SpoV) proteins  of Bacillus subtilis which includes SpoVM. SpoVM is an small,  26 residue-long protein that is produced in the mother cell chamber  of the sporangium during the process of sporulation in B. subtilis.  SpoVM forms an amphipathic alpha-helix and is recruited to the polar  septum shortly after the sporangium undergoes asymmetric division.  The function of SpoVM depends on proper subcellular localisation  .. 
+PF08184 Cuticle protein 7 isoform family<br>Short protein clustering. This family consists of cuticle protein 7 isoforms that are  isolated from the carapace cuticle of a juvenile horseshoe crab, Limulus polyphemus. There are 3 isoforms of cuticle  protein 7. The 3 isoforms are N-terminally blocked but could  be deblocked by treatment with pyroglutaminase, showing that  the N-terminal residue is a pyroglutamine residue  . . 
+PF08186 Wound-inducible basic protein family<br>Short protein clustering. This family consists of the wound-inducible basic proteins  from plants. The metabolic activities of plants are  dramatically altered upon mechanical injury or pathogen  attack. A large number of proteins accumulates at wound or  infection sites, such as the wound-inducible basic proteins.  These proteins are small, 47 amino acids in length, has no  signal peptides and are hydrophilic and basic  .. 
+PF08187 Myoactive tetradecapeptides family<br>Short protein clustering. This family consists of myoactive tetradecapeptides that are  isolated from the gut of earthworms, Eisenia foetida and  Pheretima vitata. These peptides were termed ETP and PTP  respectively. Both peptides showed a potent excitatory action  on spontaneous contractions of the anterior gut. These peptides  show similarity to Molluscan tetradecapeptides and arthropodan  tridecapeptides  .. 
+PF08188 Spermatozal protamine family<br>Short protein clustering. This family consists of the spermatozal protamines.  Spermatozal protamines play an important role in remodelling of the sperm chromatin during mammalian spermiogenesis. Nuclear elongation and chromatin condensation are concomitant with modifications in the basic protein complement associated with DNA.  Somatic histones are initially replaced by testis -specific histone variants, then by transitional proteins, and ultimately by protamines  .. 
+PF08189 Meleagrin/Cygnin family<br>Short protein clustering. This family consists of meleagrin and cygnin basic peptides that are isolated from turkey and black swan respectively. Both peptides are low in molecular weight and contains three disulphide bonds with high concentrations of aromatic residues. These peptides show similarity to transferrins and probably play some vital role in avian eggs but the exact function is still unknown  .. 
+PF08190 Nop17p; <br>pre-RNA processing PIH1/Nop17. Pfam-B_10462 (release 16.0). This domain is involved in pre-rRNA processing  .  It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae  . The C-terminal region of this family has similarity to the CS domain Pfam:PF04969.. 
+PF08191 LRR adjacent<br>Mistry J, Schubert WD. Pfam-B_1177 (release 16.0). These are small, all beta strand domains, structurally described for the protein Internalin (InlA) and related proteins InlB, InlE, InlH from the pathogenic bacterium Listeria monocytogenes. Their function appears to be mainly structural: They are fused to the C-terminal end of leucine-rich repeats (LRR), significantly stabilising the LRR, and forming a common rigid entity with the LRR.  They are themselves not involved in protein-protein-interactions but help to present the adjacent LRR-domain for this purpose.  These domains belong to the family of Ig-like domains in that they consist of two sandwiched beta sheets that follow the classical connectivity of Ig-domains. The beta strands in one of the sheets is, however, much smaller than in most standard Ig-like domains, making it somewhat of an outlier      .. 
+PF08192 Peptidase family S64<br>Mistry J, Rawlings N. This family of fungal proteins is involved in the processing of membrane bound transcription factor Stp1  .  The processing causes the signalling domain of Stp1 to be passed to the nucleus where several permease genes are induced.  The permeases are important for uptake of amino acids, and processing of tp1 only occurs in an amino acid-rich environment.  This family is predicted to be distantly related to the trypsin family (MEROPS:S1) and to have a typical trypsin-like catalytic triad  .. 
+PF08193 DUF1711; <br>INO80 complex subunit Ies4. The INO80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodelling complex.  This family of proteins corresponds to the fungal Ies4 subunit of INO80.. 
+PF08194 DIM protein<br>Short protein clustering. Drosophila immune-induced molecules (DIMs) are short proteins induced during the immune response of Drosophila. This family includes DIMs 1 to 4 that have masses below 5 kDa  .. 
+PF08195 TRI9 protein<br>Short protein clustering. Putative gene of 129 bp in the Trichothecene gene cluster of Fusarium sporotrichioides and F. graminearum. Encoding a predicted protein of 43 amino acids which function is unknown [1,2].. 
+PF08196 UL2 protein<br>Short protein clustering. Orf UL2 of Human cytomegalovirus (HCMV) which is a short protein of unknown function  . 
+PF08197 pORF2a truncated protein<br>Short protein clustering. Most isolated ORF2 of TT virus (TTV) encode a 49 amino acids protein  (pORF2a) because of an in-frame stop codon. ORF2s isolated from G1 TTV  encode 202 amino acids protein (pORF2ab)  .  . 
+PF08198 Thymopoietin protein<br>Short protein clustering. Short protein of 49 amino acid isolated from bovine spleen cells  . Thymopoietins (TMPOs) are a group of ubiquitously expressed nuclear proteins. They are suggested to play an important role in nuclear envelope organisation and cell cycle control  .. 
+PF08199 Bacteriophage E2-like protein<br>Short protein clustering. Short conseved protein described in Lactococcus Bacteriophage c2  of 37 amino acids  .. 
+PF08200 Bacteriophage 1.1 Protein <br>Short protein clustering. Gene 1.1 in Bacteriophage T7 encodes a 42 amino acid protein, rich in basic amino acids suggesting its interaction with nucleic acids  .  Many homologs are present in different T7 and T3-like bacteriophage.. 
+PF08201 BssC/TutF protein<br>Short protein clustering. BssC short protein (57 amino acids) has been described as the  gamma-subunit of benzylsuccinate synthase from Thauera aromatica  strain K172  .  TutF has been identified and described as highly similar to BssC in  T.aromatica strain T1  . . 
+PF08202 Mis12_component;<br>Mis12-Mtw1 protein family. Pfam-B_127825  (release 16.0). Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation  .. 
+PF08203 Yeast RNA polymerase I subunit RPA14<br>This is a family of yeast proteins.  A14 is one of the final two subunits of Saccharomyces cerevisiae RNA polymerase I and is proposed to play a role in the recruitment of pol I to the promoter  .. 
+PF08204 CD47 immunoglobulin-like domain<br>Pfam-B_2739 (release 7.5). This family represents the CD47 leukocyte antigen V-set like Ig domain [1,2].. 
+PF08205 CD80-like C2-set immunoglobulin domain <br>Pfam-B_280 (release 17.0). These domains belong to the immunoglobulin superfamily.. 
+PF08206 Ribonuclease B OB domain<br>Pfam-B_484 (release 17.0). This family includes the N-terminal OB domain found in ribonuclease B proteins in one or two copies.. 
+PF08207 Elongation factor P (EF-P) KOW-like domain<br>
+PF08208 RNA_polI_final; <br>DNA-directed RNA polymerase I subunit RPA34.5. This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription  .. 
+PF08209 Sgf11 (transcriptional regulation protein)<br>The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae.  The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation  .. 
+PF08210 APOBEC-like N-terminal domain<br>A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes.  The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain.  RNA editing by APOBEC-1 requires homodimerisation and this  complex interacts with RNA binding proteins to from the editosome    (and references therein). This family also includes the functionally  homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea  lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like  role in the adaptive immune response of jawless vertebrates  .  Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and  prokaryotes such as Wolbachia and Pseudomonas brassicacearum  .. 
+PF08211 Cytidine and deoxycytidylate deaminase zinc-binding region <br>Pfam-B_8221 (release 16.0). 
+PF08212 Lipocalin-like domain<br>Pfam-B_2479 (Release 17.0). Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The structure is an eight-stranded beta barrel.. 
+PF08213 Mitochondrial domain of unknown function (DUF1713)<br>This domain is found at the C terminal end of mitochondrial proteins of unknown function.. 
+PF08214 DUF1714; RTT109; <br>Histone acetylation protein. Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation.  Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin  . KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast  .  This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11  .. 
+PF08216 DUF1716;<br>Catenin-beta-like, Arm-motif containing nuclear. Pfam-B_13045 (release 16.0). CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain (Swiss:Q8WYA6) is thought to have a role in apoptosis  . The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners [2,3].. 
+PF08217 Fungal domain of unknown function (DUF1712)<br>The function of this family of proteins is unknown.. 
+PF08218 Citrate lyase ligase C-terminal domain<br>Pfam-B_3588 (release 16.0). This family is composed of the C-terminal domain of citrate lyase ligase EC:6.2.1.22.. 
+PF08219 Outer membrane protein TOM13<br>The TOM13 family of proteins are mitochondrial outer membrane proteins that mediate the assembly of beta-barrel proteins  .. 
+PF08220 DeoR-like helix-turn-helix domain<br>
+PF08221 RNA polymerase III subunit RPC82 helix-turn-helix domain<br>Pfam-B_9884 (release 8.0). This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa  . This region is a probably DNA-binding helix-turn-helix.. 
+PF08222 CodY helix-turn-helix domain<br>Pfam-B_7573 (release 9.0). This family consists of the C-terminal helix-turn-helix domain found in several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions  . The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk  .. 
+PF08223 PaaX-like protein C-terminal domain<br>Pfam-B_9563 (release 14.0). This family contains proteins that are similar to the product  of the paaX gene of Escherichia coli (Swiss:P76086). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid  . . 
+PF08224 Domain of unknown function (DUF1719)<br>Mistry J, Myung-il K. Pfam-B_27966 (release 16.0). This is a domain of unknown function.  It may have a role in ATPase activation.. 
+PF08225 Pseudin antimicrobial peptide<br>Short protein clustering. Pseudins are a subfamily of the FSAP family (Frog Secreted Active Peptides) extracted from the skin of the paradoxical frog Pseudis paradoxa (Pseudidae).  The pseudins belong to the class of cationic, amphipathic-helical antimicrobial peptides  .. 
+PF08226 Domain of unknown function (DUF1720)<br>Pfam-B_19709 (release 16.0). This domain is found in different combinations with cortical patch components EF hand, SH3 and ENTH and is therefore likely to be involved in cytoskeletal processes.  This family contains many hypothetical proteins.. 
+PF08227 DUF1721; <br>DASH complex subunit Hsk3 like. The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.. 
+PF08228 RNase P subunit Pop3<br>This family of fungal proteins form a subunit of RNase P, the ribonucleoprotein enzyme that cleaves the leader sequence of precursor tRNAs to generate mature tRNAs.\.   The structure of Pop3 has been assigned the L7Ae/L30e fold  .\. This RNA-binding fold is also present in human RNase P subunit Rpp38, raising the possibility that Pop3p and Rpp38 are functional homologs.. 
+PF08229 ER membrane protein SH3 <br>This family of proteins are membrane localised chaperones that are required for correct plasma membrane localisation of amino acid permeases (AAPs)  .  SH3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of SH3, AAPs are retained in the ER.. 
+PF08230 Cpl-7 lysozyme C-terminal domain<br>This domain was originally found in the C-terminal moiety of the Cpl-7 lysozyme encoded by the Streptococcus pneumoniae bacteriophage Cp-7 (Swiss:P19385). It is assumed that these repeats represent cell wall binding motifs although no direct evidence has been obtained so far.. 
+PF08231 SYF2 splicing factor<br>Pfam-B_11988 (release 17.0). Proteins in this family are involved in cell cycle progression and pre-mRNA splicing    .. 
+PF08232 Striatin family<br>Pfam-B_7946 (release 17.0). Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (Pfam:PF00400) repeat domain  . It acts as a scaffold protein   and is involved in signalling pathways    .. 
+PF08234 Chromosome segregation protein Spc25<br>Pfam-B_14484 (release 16.0). This is a family of chromosome segregation proteins.  It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex  , and in vertebrates it forms part of the Ndc80 complex  .. 
+PF08235 LNS2 (Lipin/Ned1/Smp2)<br>Pfam-B_2646 (release 16.0). This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins  .  SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration  , and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain  .  Lipin proteins are involved in adipose tissue development and insulin resistance  .. 
+PF08236 SRI (Set2 Rpb1 interacting) domain<br>Pfam-B_106465 (release 17.0) & pdb_2a7o. The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation  .  This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilises the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation  .. 
+PF08237 PE-PPE domain<br>This domain is found C terminal to the PE (Pfam:PF00934) and PPE (Pfam:PF00823) domains.  The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands  .. 
+PF08238 Sel1 repeat<br>Pfam-B_49 (Release 17.0). This short repeat is found in the Sel1 protein  .  It is related to TPR repeats.. 
+PF08239 Bacterial SH3 domain<br>Pfam-B_178 (Release 17.0). 
+PF08240 Alcohol dehydrogenase GroES-like domain<br>Pfam-B_7 (Release17.0). This is the catalytic domain of alcohol dehydrogenases.  Many of them contain an inserted zinc binding domain. This domain  has a GroES-like structure [1-2].. 
+PF08241 Methyltransferase domain<br>Pfam-B_21 (release 17.0). Members of this family are SAM dependent methyltransferases.. 
+PF08242 Methyltransferase domain<br>Pfam-B_46 (release 17.0). Members of this family are SAM dependent methyltransferases.. 
+PF08243 SPT2 chromatin protein<br>This family includes the Saccharomyces cerevisiae protein SPT2 which is a chromatin protein involved in transcriptional regulation  .. 
+PF08244 glycosyl_hydro2; Glyco_hydro_32; <br>Glycosyl hydrolases family 32 C terminal. This domain corresponds to the C terminal domain of glycosyl hydrolase family 32.  It forms a beta sandwich module  .. 
+PF08245 Mur ligase middle domain<br>Pfam-B_26 (release 17.0). 
+PF08246 Cathepsin propeptide inhibitor domain (I29)<br>Pfam-B_14 (release 17.0) . This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide.  There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin Swiss:Q70SU8. This family is classified as I29 by MEROPS.. 
+PF08247 ENOD40 protein<br>Short protein clustering. Rohrig et al. reported the in vitro translation of two peptides of 12 and 24 amino acids from the short, overlapping ORFs of soybean ENOD40 mRNA  . The putative role of the enod40 genes has been in favour of organogenesis, such as induction of the cortical cell divisions that lead to initiation of nodule primordia, in developing lateral roots and embryonic tissues. This supports the hypothesis for a role of enod40 in lateral organ development  .. 
+PF08248 Tryptophyllin-3 skin active peptide<br>Short protein clustering. PdT-3 or Tryptophyllin-3 peptide is a subfamily of the family Tryptophyllin and of the superfamily FSAP (Frog Skin Active Peptide).  Originally identified in skin extracts of Neotropical leaf frogs, Phyllomedusa sp. This subfamily has an average length of 13 amino acids. The pharmacological activity of the tryptophyllins remains to be established   but it seems that these peptides possess an action on liver protein synthesis and body weight  .. 
+PF08249 Mastoparan protein<br>Short protein clustering. Mastoparans are a family of tetradecapeptides from wasp venom, that have been shown to directly activate GTP-binding regulatory proteins.  These peptides show selectivity among G proteins: they strongly activate Go and Gi but not Gs or Gt.  The peptide of this family are composed by 14 amino acids but they can assume different structures  .. 
+PF08250 Sperm-activating peptides<br>Short protein clustering. The sperm-activating peptides (SAPs) are isolated in egg-conditioned media (egg jelly) of sea urchins. SAPs have several effects on sea urchin spermatozoa: stimulate sperm respiration and motility through intracellular alkalinization, transient elevation of cAMP, cGMP and Ca++levels in sperm cells [1,2].. 
+PF08251 Mastoparan peptide<br>Short protein clustering. Mastoparan (MP) peptides I II and III are extracted from the venom  gland of the Neotropical social wasp Protopolybia exigua(Saussure) They are tetradecapeptides presenting from seven to ten  hydrophobic amino acid residues and from two to four lysine  residues in their primary sequences. These peptide cause the degranulation of mast cells. Protopolybia-MP-I also act causing hemolysis in erythrocytes.. 
+PF08252 arg-2/CPA1 leader peptide <br>Short protein clustering. In this family there are Leaders Peptides involved in the regulation the glutaminase subunit (small subunit) of arginine-specific carbamoyl phosphate synthetase.  In Neurospora crassa it is a small upstream ORF of 24 codon above the arg-2 locus  . In yeast it is the leader peptide of the CPA1 gene. The 5' region of CPA1 mRNA contains a 25 codon upstream open reading frame. The leader peptide, the product of the upstream open reading frame, plays an essential, negative role in the specific repression of CPA1 by arginine  .. 
+PF08253 Erm Leader peptide <br>Short protein clustering. These short proteins are Leader peptides (15-19 amino acids) of  erm genes that code for resistance determinants in Staphylococcus  aureus  .. 
+PF08254 Threonine leader peptide<br>Short protein clustering. Threonine leader peptide of the Threonine operon thrA1A2BC.  It as been sequenced in different bacteria: E. coli, Serratia marcescens, Salmonella typhi [1,2].. 
+PF08255 Trp-operon Leader Peptide<br>Short protein clustering. The tryptophan operon regulatory region of C. freundii's (leader transcript) encodes a 14-residue peptide containing characteristic tandem tryptophan residues. It is about 10 nucleotides shorter than those of E. coli and S. typhimurium  .. 
+PF08256 Aurein-like antibiotic peptide<br>Short protein clustering. This family of antibacterial peptides are secreted from the granular dorsal glands of the Green and Golden Bell Frog Litoria aurea, Southern Bell Frog L. raniformis, Blue Mountains tree-frog Litoria citropa (genus Litoria) and frogs from genus Uperoleia. They are a part of the FSAP peptide family.  Amongst the more active of these are aurein 1.2, aurein 2.2 and aurein 3.1; caerin 1.1, maculatin 1.1, uperin 3.6  ; citropin 1.1, citropin 1.2, citropin 1.3 and a minor peptide are wide-spectrum antibacterial peptides  .. 
+PF08257 Sulfakinin family<br>Short protein clustering. The sulfakinin (SK) family of neuropeptides have only been identified in crustaceans and insects.  For most species there is the potential for producing two sulfakinin peptides one have a short sulfakinin sequence The function of the sulfakinins is difficult to assess.  For the American cockroach, various forms of the endogenous sulfakinins have been shown to be active on the hindgut, and also on the heart.  In C. vomitoria the peptides act as neurotransmitters or neuromodulators, linking the brain with all thoracic and abdominal ganglia.  In adults of P. monodon they appear to be restricted to a few neurones in the brain with a neural pathway extending along to the ventral thoracic and abdominal ganglia  .. 
+PF08258 WWamide peptide<br>Short protein clustering. This family contain neuropeptides, isolated from ganglia of the African giant snail, Achatina fulica.  Each peptide has a Trp residue at both the N- and C-termini.  Purified WWamide-1, -2 and -3 showed an inhibitory effect on the phasic contractions of the anterior byssus retractor muscle (ABRM)  .. 
+PF08259 Periviscerokinin family<br>Short protein clustering. Abdominal Perisympathetic organs of insects contain  Periviscerokinins neuropeptides of about 11 amino acids. . 
+PF08260 Insect kinin peptide<br>Short protein clustering. These neuropeptides are the first members of the insect kinin-family isolated from the American cockroach. Their occurrence in the retrocerebral complex suggests a physiological role as a neurohormone. The C-terminal sequence Phe-X-Ser-Trp-Gly-NH2 characterised the peptides as members of the insect kinin family.  Data suggest a possible involvement of insect kinins in water-balance by regulating the osmoregulation. These peptides have length from 6 to 14 amino acids  .. 
+PF08261 Carcinustatin peptide<br>Short protein clustering. A total of 20 peptides of the superfamily allostatin were isolated from the shore crab Carcinus maenas. They are named carcinustatin 1 to 20 and their length ranges from 5 to 27 amino acids. This family includes carcinustatin 8,9,15 and 16.. 
+PF08262 Leucophaea maderae tachykinin-related peptide <br>Short protein clustering. These peptides are designated Leucophaea maderae tachykinin-related peptides (Lem TRPs). Some were isolated from the midgut of L. maderae, whereas others appear to be brain specific.  The Lem TRPs of the brain are myotropic and induce increases in the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle in L. maderae  .  They were also isolated from brain-corpora, cardiaca-corpora, allata-suboesophageal ganglion extracts of the Locusta migratoria.  They stimulate visceral muscle contractions of the oviduct and the foregut of Locusta migratoria  .. 
+PF08263 Leucine rich repeat N-terminal domain<br>Pfam-B_35 (release 17.0). Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.. 
+PF08264 Anticodon-binding domain of tRNA<br>Pfam-B_23 (Release 17.0). This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA.. 
+PF08265 YL1 nuclear protein C-terminal domain<br>Pfam-B_3088 (release 8.0). This domain is found in proteins of the YL1 family  . These proteins have been shown to be DNA-binding and may be a transcription factor  . This domain is found in proteins that are not YL1 proteins.. 
+PF08266 Cadherin-like<br>Pfam-B_179 (release 17.0). This cadherin domain is usually the most N-terminal copy of the domain.   . 
+PF08267 Cobalamin-independent synthase, N-terminal domain<br>Pfam-B_553 (release 17.0). The N-terminal domain and C-terminal domains of cobalamin-independent synthases together define a catalytic cleft in the enzyme.  The N-terminal domain is thought to bind the substrate, in particular, the negatively charged polyglutamate chain.  The N-terminal domain is also thought to stabilise a loop from the C-terminal domain  .. 
+PF08268 F-box associated domain<br>Pfam-B_322 (release 17.0). 
+PF08269 Cache domain<br>Pfam-B_865 (release 17.0). 
+PF08270 M protein trans-acting positive regulator (MGA) PRD domain<br>Pfam-B_5126 (release 7.7). Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions  . This corresponds to the PRD like region.. 
+PF08271 TFIIB_Zn_Ribbon;<br>Pfam-B_1298 (release 17.0). The transcription factor TFIIB contains a zinc-binding motif near the N-terminus.  This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site.  The domain adopts a zinc ribbon like structure  .. 
+PF08272 Topoisomerase I zinc-ribbon-like <br>Pfam-B_5615 (release 17.0). Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to Pfam:PF01396. However, this domain no longer bind zinc.  Indeed, only one of the four cysteine residues remains  .. 
+PF08273 Zinc-binding domain of primase-helicase<br>Pfam-B_18441 (release 17.0). 
+PF08274 PhnA Zinc-Ribbon <br>
+PF08275 DNA primase catalytic core, N-terminal domain<br>Pfam-B_313 (release 17.0). 
+PF08276 PAN-like domain<br>Pfam-B_291 (release 17.0). 
+PF08277 PAN-like domain<br>Pfam-B_1455 (release 17.0). 
+PF08278 DNA primase DnaG DnaB-binding <br>Pfam-B_3213 (release 17.0). Eubacterial DnaG primases interact with several factors to from the replisome.  One of these factors in DnaB, a helicase.  This domain has been demonstrated to be responsible for the interaction between DnaG and DnaB .. 
+PF08279 HTH domain<br>Pfam-B_125 (Release 17.0). This family includes helix-turn-helix domains in a wide variety of proteins.. 
+PF08280 M protein trans-acting positive regulator (MGA) HTH domain<br>Pfam-B_5126 (release 7.7). Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions  .. 
+PF08281 Sigma-70, region 4<br>Pfam-B_125 (Release 17.0). Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif  .. 
+PF08282 haloacid dehalogenase-like hydrolase<br>Pfam-B_66 (Release 17.0). This family contains haloacid dehalogenase-like hydrolase enzymes.. 
+PF08283 Geminivirus rep protein central domain<br>Pfam-B_286 (release 2.1). This is the cetral domain of the geminivirus rep proteins  .. 
+PF08284 Retroviral aspartyl protease<br>Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases. 
+PF08285 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)<br>This family corresponds to subunit 3 of dolichol-phosphate mannosyltransferase, an enzyme which generates mannosyl donors for glycosylphosphatidylinositols, N-glycan and protein O- and C-mannosylation.  DPM3 is an integral membrane protein and plays a role in stabilising the dolichol-phosphate mannosyl transferase complex  .. 
+PF08286 Spc24 subunit of Ndc80<br>Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation  . 
+PF08287 Spc19; <br>Spc19 is a component of the DASH complex.\.      The DASH complex associates with the spindle pole body and is important for spindle and kinetochore integrity during cell division   .. 
+PF08288 PIGA (GPI anchor biosynthesis)<br>Pfam-B_6971 (release 17.0). This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria  .. 
+PF08289 Influenza Matrix protein (M1) C-terminal domain<br>Pfam-B_30 (Release 17.0). This region is thought to be a second domain of the M1 matrix protein.. 
+PF08290 Hepatitis core protein, putative zinc finger<br>This short region is found at the N-terminus of some hepatitis core proteins.\.  Its conservation of four cys and his suggests a zinc binding domain.. 
+PF08291 Peptidase M15 <br>
+PF08292 RNA polymerase III subunit Rpc25<br>Pfam-B_9841 (release 17.0). Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III  .. 
+PF08293 Mit_rib_S27; <br>Mitochondrial ribosomal subunit S27. Pfam-B_31036 (release 17.0). This family of proteins corresponds to mitochondrial ribosomal subunit S27 in prokaryotes   and to subunit S33 in humans  . It is a small 106 residue protein.The evolutionary history of the mitoribosomal proteome that is encoded by a diverse subset of eukaryotic genomes, reveals an ancestral ribosome of alpha-proteobacterial descent that more than doubled its protein content in most eukaryotic lineages. Several new MRPs have originated via duplication of existing MRPs as well as by recruitment from outside of the mitoribosomal proteome  .. 
+PF08294 TIM21<br>TIM21 interacts with the outer mitochondrial TOM complex and promotes the insertion of proteins into the inner mitochondrial membrane  .. 
+PF08295 HDAC_interact;<br>Sin3 family co-repressor. Pfam-B_2731 (release 17.0). This domain is found on transcriptional regulators.  It forms interactions with histone deacetylases  .. 
+PF08297 U3_snoRNA; <br>U3 snoRNA associated. This family of proteins is associated with U3 snoRNA  . U3 snoRNA is required for nucleolar processing of pre-18S ribosomal RNA.. 
+PF08298 PrkA AAA domain<br>Pfam-B_3917 (release 10.0). This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain  .. 
+PF08299 Bacterial dnaA protein helix-turn-helix<br>
+PF08300 Hepatitis C virus non-structural 5a zinc finger domain<br>The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2]. This domain corresponds to the N-terminal zinc binding domain  .. 
+PF08301 Hepatitis C virus non-structural 5a domain 1b<br>The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2]. This region corresponds to the 1b domain  .. 
+PF08302 Fungal tRNA ligase phosphodiesterase domain<br>Pfam-B_49998 (release 17.0). This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity  .  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.. 
+PF08303 tRNA ligase kinase domain<br>Pfam-B_49998 (release 17.0). This domain is found in fungal tRNA ligases and has kinase activity  .  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.. 
+PF08305 NPCBM/NEW2 domain<br>This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.). 
+PF08306 Glycosyl hydrolase family 98<br>This domain is the putative catalytic domain of glycosyl hydrolase family 98 proteins.. 
+PF08307 Glycosyl hydrolase family 98 C-terminal domain<br>This putative domain is found at the C-terminus of glycosyl hydrolase family 98 proteins. This domain is not expected to form part of the catalytic activity.. 
+PF08308 PEGA domain<br>This domain is found in both archaea and bacteria and has similarity to S-layer (surface layer) proteins.  It is named after the characteristic PEGA sequence motif found in this domain. The secondary structure of this domain is predicted to be beta-strands [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].. 
+PF08309 LVIVD repeat<br>This repeat is found in bacterial and archaeal cell surface proteins, many of which are hypothetical.  The secondary structure corresponding to this repeat is predicted to comprise 4 beta-strands which may associate to form a beta-propeller [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  The repeat copy number varies from 2-14.  This repeat is sometimes found with the PKD domain Pfam:PF00801.. 
+PF08310 LGFP repeat<br>This 54 amino acid repeat is found in many hypothetical proteins. Several hypothetical proteins from C.glutamicum and C.efficiens along with PS1 protein contain this repeat region. The N-terminus region of PS1 contains an esterase domain which transfers corynomycolic acid. The C-terminus region consists of 4 tandem LGFP repeats. It is hypothesised that the PS1 proteins in Corynebacterium, when associated with the cell wall, may be anchored via the LGFP tandem repeats that may be important for maintaining cell wall integrity [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  Deletion of Swiss:Q01377 protein results in a 10-fold increase in the cell volume of the organism and infers the corresponding proteins involvement in the cell shape formation  . The secondary structure of each repeat is predicted to comprise two beta-strands and one alpha-helix [Adindla et al. 2004].. 
+PF08311 Mad3/BUB1 homology region 1<br>Pfam-B_3330 (release 17.0). Proteins containing this domain are checkpoint proteins involved in cell division.  This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p  .. 
+PF08312 cwf21 domain<br>Pfam-B_14400 (release 17.0). The cwf21 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe  . The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding  . The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.. 
+PF08313 SCA7, zinc-binding domain<br>Pfam-B_21229 (release 17.0). This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK  .  This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7)  .  Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain  .. 
+PF08314 Secretory pathway protein Sec39<br>Mistry J, Wood V, Schmitt HD. Mnaimneh et al   identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes.  Kraynack et al. (2005)   showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006)  .. 
+PF08315 cwf18 pre-mRNA splicing factor <br>Pfam-B_19718 (release 17.0). The cwf18 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe  .. 
+PF08316 Pal1 cell morphology protein<br>Pal1 is a membrane associated protein that is involved in the maintenance of cylindrical cellular morphology.  It localises to sites of active growth.  Pal1 physically interacts and displays overlapping localisation with the Huntingtin-interacting-protein (Hip1)-related protein Sla2p/End4p  .. 
+PF08317 Spc7 kinetochore protein<br>This domain is found in cell division proteins which are required for kinetochore-spindle association  .. 
+PF08318 Sec38; <br>COG4 transport protein. This region is found in yeast oligomeric golgi complex component 4 which is involved in ER to Golgi an intra Golgi transport  .. 
+PF08320 PIG-X / PBN1<br>Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I  .  These enzymes are involved in the transfer of sugar molecules.. 
+PF08321 PPT1; <br>PPP5 TPR repeat region. Pfam-B_6912 (release 17.0). This region is specific to the PPP5 subfamily of serine/threonine phosphatases and contains TPR repeats.. 
+PF08323 Starch synthase catalytic domain<br>Pfam-B_148 (Release 17.0). 
+PF08324 PUL domain<br>The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain.  It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates   .. 
+PF08325 WLM domain<br>This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases).  These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation  .. 
+PF08326 Acetyl-CoA carboxylase, central region<br>Pfam-B_2008 (release 18.0). The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (Pfam:PF01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyses the rate-limiting step in this process.. 
+PF08327 Activator of Hsp90 ATPase homolog 1-like protein<br>Pfam-B_4145 (release 18.0). This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38, Swiss:O95433). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity  . It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress  . p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport  . It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family (Swiss:Q8XY04 and Swiss:Q6MH87).. 
+PF08328 Adenylosuccinate lyase C-terminal<br>Pfam-B_1176 (release 18.0). This domain is found at the C-terminus of adenylosuccinate lyase(ASL; PurB in E. coli). It has been identified in bacteria, eukaryotes and archaea and is found together with the lyase domain Pfam:PF00206.  ASL catalyses the cleavage of succinylaminoimidazole carboxamide ribotide to aminoimidazole carboxamide ribotide and fumarate and the cleavage of adenylosuccinate to adenylate and fumarate  .. 
+PF08329 Chitinase A, N-terminal domain<br>Pfam-B_1049 (release 18.0). This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [1,2]. It is separated by a hinge region from the catalytic domain (Pfam:PF00704); this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution  .. 
+PF08331 Domain of unknown function (DUF1730)<br>Pfam-B_1023 (release 18.0). This domain of unknown function occurs in Iron-sulfur cluster-binding proteins together with the 4Fe-4S binding domain (Pfam:PF00037).. 
+PF08332 Calcium/calmodulin dependent protein kinase II Association<br>Pfam-B_1025 (release 18.0). This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII).  These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus  .  The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers  .. 
+PF08333 Protein of unknown function (DUF1725)<br>Pfam-B_2110 (release 18.0). This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.. 
+PF08334 GSPII_G;<br>Type II secretion system (T2SS), protein G. Pfam-B_1144 (release 18.0). The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria [1,2]. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme  . Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet  .. 
+PF08335 GlnD PII-uridylyltransferase<br>Pfam-B_2147 (release 18.0). This is a family of bifunctional uridylyl-removing enzymes/uridylyltransferases (UR/UTases, GlnD) that are responsible for the modification (EC:2.7.7.59) of the regulatory protein P-II, or GlnB (e.g. Swiss:P05826, Pfam:PF00543). In response to nitrogen limitation, these transferases (e.g. Swiss:P27249) catalyse the uridylylation of the PII protein, which in turn stimulates deadenylylation of glutamine synthetase (GlnA). Deadenylylated glutamine synthetase is the more active form of the enzyme  . Moreover, uridylylated PII can act together with NtrB and NtrC to increase transcription of genes in the sigma54 regulon, which include glnA and other nitrogen-level controlled genes  . It has also been suggested that the product of the glnD gene is involved in other physiological functions such as control of iron metabolism in certain species  . The region described in this family is found in many of its members to be C-terminal to a nucleotidyltransferase domain (Pfam:PF01909), and N-terminal to an HD domain (Pfam:PF01966) and two ACT domains (Pfam:PF01842)  .. 
+PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region<br>Pfam-B_2013 (release 18.0). The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase [1-4]. The function of the N-terminal region featured in this family does not seem to be known.. 
+PF08337 Plexin cytoplasmic RasGAP domain<br>Pfam-B_3123 (release 18.0). This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytoplasmic region, which has been called a SEX domain in some members of this family  , is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins  . This domain acts as a RasGAP domain  .. 
+PF08338 Domain of unknown function (DUF1731)<br>Pfam-B_1045 (release 18.0). This domain of unknown function appears towards the C-terminus of proteins of the NAD dependent epimerase/dehydratase family (Pfam:PF01370) in bacteria, eukaryotes and archaea.  Many of the proteins in which it is found are involved in cell-division inhibition.. 
+PF08339 RTX C-terminal domain<br>Pfam-B_2178 (release 18.0). This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli (Swiss:P09983) and Actinobacillus pleuropneumoniae (Swiss:P15377). RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes  . This region is found in association with the RTX N-terminal domain (Pfam:PF02382) and multiple hemolysin-type calcium-binding repeats (Pfam:PF00353).. 
+PF08340 Domain of unknown function (DUF1732)<br>Wuster A, Eberhardt R. Pfam-B_1065 (release 18.0). This domain of unknown function is often found at the C-terminus of bacterial proteins, many of which are hypothetical, including proteins of the YicC family which have Pfam:PF03755 at the N-terminus. These include a protein important in the stationary phase of growth, and required for growth at high temperature  . Structural modelling suggests this domain may bind nucleic acids  .. 
+PF08341 Fibronectin-binding protein signal sequence<br>Pfam-B_4004 (release 18.0). This domain is found near the N-terminus of fibronectin-binding proteins in Streptococcus where it functions as a signal sequence  .. 
+PF08343 Ribonucleotide reductase N-terminal<br>Pfam-B_1066 (release 18.0). This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyse the formation of deoxyribonucleotides  . It occurs together with the RNR all-alpha domain (Pfam:PF00317) and the RNR barrel domain (Pfam:PF02867).. 
+PF08344 Transient receptor ion channel II<br>Pfam-B_1032 (release 18.0). This domain is found in the transient receptor ion channel (Trp) family of proteins.  There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors  .  This domain does not tend to appear with the TRP domain (Pfam:PF06011) but is often found to the C-terminus of Ankyrin repeats (Pfam:PF00023).. 
+PF08345 Flagellar M-ring protein C-terminal<br>Pfam-B_1149 (release 18.0). This domain is found in bacterial flagellar M-ring (FliF) proteins together with the YscJ/FliF domain (Pfam:PF01514).. 
+PF08346 AntA/AntB antirepressor<br>Pfam-B_2097 (release 18.0). In E. coli the two proteins AntA and AntB have 62% amino acid identities near their N termini. AntA appears to be encoded by a truncated and divergent copy of AntB.  The two proteins are homologous to putative antirepressors found in numerous bacteriophages, such as the hypothetical antirepressor protein encoded by the gene LO142 of the bacteriophage 933W  .. 
+PF08347 N-terminal CTNNB1 binding<br>Pfam-B_2064 (release 18.0). This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (Pfam:PF00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation  .  Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation [1,2].. 
+PF08348 YheO; <br>YheO-like PAS domain. Pfam-B_2023 (release 18.0). This family contains various hypothetical bacterial proteins that are similar to the E. coli protein YheO (Swiss:P64624). Their function is unknown, but are likely to be involved in signalling based on the presence of this PAS domain.. 
+PF08349 Protein of unknown function (DUF1722)<br>Pfam-B_4169 (release 18.0). This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.. 
+PF08350 Domain of unknown function (DUF1724)<br>Pfam-B_1158 (release 18.0). This domain of unknown function has so far only been found at the C-terminus of archaean proteins, including several transcriptional regulators of the ArsR family (see Pfam:PF01022).. 
+PF08351 Domain of unknown function (DUF1726)<br>Wuster A, Eberhardt R. Pfam-B_3131 (release 18.0). This domain of unknown function is often found at the N-terminus of proteins containing Pfam:PF05127. Its fold resembles that of Pfam:PF05127, but it does not appear to bind ATP  .. 
+PF08352 Oligopeptide/dipeptide transporter, C-terminal region<br>Pfam-B_3025 (release 18.0). This family features a region found towards the C-terminus of oligopeptide ABC transporter ATP binding proteins, immediately following the ATP-binding domain (Pfam:PF00005). All characterised members appear able to be involved in the transport of oligopeptides or dipeptides. Some are important for sporulation or antibiotic resistance. Some dipeptide transporters also act on the heme precursor delta-aminolevulinic acid.. 
+PF08353 Domain of unknown function (DUF1727)<br>Pfam-B_2131 (release 18.0). This domain of unknown function is found at the C-terminus of bacterial proteins which include UDP-N-acetylmuramyl tripeptide synthase and the related Mur ligase.. 
+PF08354 Domain of unknown function (DUF1729)<br>Pfam-B_3179 (release 18.0). This domain of unknown function is found in fatty acid synthase beta subunits together with the MaoC-like domain (Pfam:PF01575) and the Acyltransferase domain (Pfam:PF00698)  .  The domain has been identified in fungi and bacteria.. 
+PF08355 EF hand associated<br>Pfam-B_4111 (release 18.0). This region typically appears on the C-terminus of EF hands in GTP-binding proteins such as Arht/Rhot (may be involved in mitochondrial homeostasis and apoptosis ).  The EF hand associated region is found in yeast, vertebrates and plants.. 
+PF08356 EF hand associated<br>Pfam-B_3018 (release 18.0). This region predominantly appears near EF-hands (Pfam:PF00036) in GTP-binding proteins. It is found in all three eukaryotic kingdoms.. 
+PF08357 SEFIR domain<br>Pfam-B_33671 (release 17.0). This family comprises IL17 receptors (IL17Rs, e.g. Swiss:Q60943) and SEF proteins (e.g. Swiss:Q8QHJ9). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (Pfam:PF01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways  .. 
+PF08358 Carlavirus coat<br>Pfam-B_2014 (release 18.0). This domain is found together with the viral coat protein domain (Pfam:PF00286) in coat/capsid proteins of Carlaviruses infecting plants.. 
+PF08359 YsiA-like protein, C-terminal region<br>Pfam-B_20730 (release 17.0). The members of this family are thought to be TetR-type transcriptional regulators that bear particular similarity to YsiA (Swiss:P94548), a hypothetical protein expressed by B. subtilis.. 
+PF08360 QacR-like protein, C-terminal region<br>Pfam-B_96140 (release 17.0). This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein (Swiss:P23217), a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA (Swiss:P23215), a multidrug efflux pump  . The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites  .. 
+PF08361 MAATS-type transcriptional repressor, C-terminal region<br>Pfam-B_3020 (release 18.0). This family is named after the various transcriptional regulatory proteins that it contains, including MtrR (Swiss:Q6RV06), AcrR (Swiss:P34000), ArpR (Swiss:Q9KJC4), TtgR (Swiss:Q9AIU0) and SmeT (Swiss:Q8KLP4). These are members of the TetR family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [1,2,3].. 
+PF08362 YcdC-like protein, C-terminal region<br>Pfam-B_4012 (release 17.0). This family comprises proteins that belong to the TetR family of transcriptional regulators. They bear particular similarity to YcdC (Swiss:P75899), a putative HTH-containing protein. This family features the C-terminal region of these sequences, which does not include the helix-turn-helix.. 
+PF08363 Glucan-binding protein C<br>Pfam-B_3074 (release 18.0). This domain is found in the Streptococcus Glucan-binding protein C (GbpC) and also in surface protein antigen (Spa)-family proteins which show sequence similarity to GbpC  .. 
+PF08364 Bacterial translation initiation factor IF-2 associated region<br>Pfam-B_3037 (release 18.0). Most of the sequences in this alignment come from bacterial translation initiation factors (IF-2, also Pfam:PF04760), but the domain is also found in the eukaryotic translation initiation factor 4 gamma in yeast and in a hypothetical Euglenozoa protein of unknown function.. 
+PF08365 Insulin-like growth factor II E-peptide<br>Pfam-B_4175 (release 18.0). This domain is found at the C-terminal domain of the insulin-like growth factor II (IGF-2, also see Pfam:PF00049) in vertebrates and seems to represent the E-peptide [1,2].. 
+PF08366 LLGL2<br>Pfam-B_4088 (release 18.0). This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn  .  It has been identified in eukaryotes and tends to be found together with WD repeats (Pfam:PF00400).. 
+PF08367 Peptidase M16C associated<br>Pfam-B_3062 (release 18.0). This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (Pfam:PF05193).. 
+PF08368 FAST kinase-like protein, subdomain 2<br>Vella Briffa B, Fenech M. Pfam-B_2858 (release 10.0). This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis  . Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.. 
+PF08369 Proto-chlorophyllide reductase 57 kD subunit<br>Pfam-B_2047 (release 18.0). This domain is found in bacteria and plant chloroplast proteins. It often appears at the C-terminal of Nitrogenase component 1 type Oxidoreductases (Pfam:PF00148) and sometimes independently in bacterial proteins such as the Proto-chlorophyllide reductase 57 kD subunit of the Cyanobacterium Synechocystis.. 
+PF08370 Plant PDR ABC transporter associated<br>Pfam-B_2126 (release 18.0). This domain is found on the C-terminus of ABC-2 type transporter domains (Pfam:PF01061).  It seems to be associated with the plant pleiotropic drug resistance (PDR) protein family of ABC transporters.  Like in yeast, plant PDR ABC transporters may also play a role in the transport of antifungal agents [1, also Pfam:PF06422].  The PDR family is characterised by a configuration in which the ABC domain is nearer the N-terminus of the protein than the transmembrane domain  .. 
+PF08372 Plant phosphoribosyltransferase C-terminal<br>Pfam-B_3195 (release 18.0). This domain is found at the C-terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins.  It contains putative transmembrane regions.  It often appears together with calcium-ion dependent C2 domains (Pfam:PF00168).. 
+PF08373 RAP domain<br>Pfam-B_5583 (release 17.0). This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain  . The domain is involved in plant defence in response to bacterial infection [2,3].. 
+PF08374 Protocadherin<br>Pfam-B_4100 (release 18.0). The structure of protocadherins is similar to that of classic cadherins (Pfam:PF00028), but particularly on the cytoplasmic domains they also have some unique features.  They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localised mainly at cell-cell contact sites.  Their expression seems to be developmentally regulated  .. 
+PF08375 Proteasome regulatory subunit C-terminal<br>Pfam-B_4098 (release 18.0). This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function  .  It occurs together with the PCI/PINT domain (Pfam:PF01399).. 
+PF08376 Nitrate and nitrite sensing<br>Pfam-B_37103 (release 17.0). The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations.  The NIT domain is predicted to be all alpha-helical in structure  .. 
+PF08377 MAP2/Tau projection domain<br>Pfam-B_26981 (release 17.0). This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs.  All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (Pfam:PF00418), and a N-terminal projection domain of varying size.  This domain has a net negative charge and exerts a long-range repulsive force.  This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport [1,2].. 
+PF08378 Nuclease-related domain<br>Pfam-B_9750 (release 17.0). The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins.  It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing  .. 
+PF08379 Bacterial transglutaminase-like N-terminal region<br>Pfam-B_2190 (release 18.0). This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (Pfam:PF01841).. 
+PF08381 DZC;<br>Transcription factor regulating root and shoot growth via Pin3. Pfam-B_2116 (release 18.0). The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2]. BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway.  BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot  . The family features a short region of alpha-helix, approximately 60 residues in length, which is found repeated up to three times  . BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action  .. 
+PF08383 Maf N-terminal region<br>Pfam-B_3103 (release 18.0). This region is found in various leucine zipper transcription factors of the Maf family. These are implicated in the regulation of insulin gene expression  , in erythroid differentiation  , and in differentiation of the neuroretina  .. 
+PF08384 Pro-opiomelanocortin, N-terminal region<br>Pfam-B_1053 (release 18.0). This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity  .. 
+PF08385 Dynein heavy chain, N-terminal region 1<br>Pfam-B_3094 (release 18.0). Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit  . The region featured in this family includes the sequences implicated in mediating these interactions  . It is thought to be flexible and not to adopt a rigid conformation  .. 
+PF08386 TAP-like protein<br>Pfam-B_3096 (release 18.0). This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans (Swiss:Q54410). A member of this family (Swiss:Q6E3K7) is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterised from Propionibacterium freudenreichii  .. 
+PF08387 FBD<br>Pfam-B_1153 (release 18.0). This region is found in F-box (Pfam:PF00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes  . In fact, several family members are annotated as being similar to transcription factors.. 
+PF08388 Group II intron, maturase-specific domain<br>Pfam-B_4063 (release 18.0). This region is found mainly in various bacterial and archaeal species, but a few members of this family are expressed by fungal and chlamydomonal species. It has been implicated in the binding of intron RNA during reverse transcription and splicing  .. 
+PF08389 Exportin 1-like protein<br>Pfam-B_4058 (release 18.0). The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1, Swiss:P14068). This region is found just C-terminal to an importin-beta N-terminal domain (Pfam:PF03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus [1,2].. 
+PF08390 TRAM1-like protein<br>Pfam-B_3108 (release 18.0). This family comprises sequences that are similar to human TRAM1 (Swiss:Q15629). This is a transmembrane protein of the endoplasmic reticulum, thought to be involved in the membrane transfer of secretory proteins  . The region featured in this family is found N-terminal to the longevity-assurance protein region (Pfam:PF03798).. 
+PF08391 Ly49-like protein, N-terminal region<br>Pfam-B_1187 (release 18.0). The sequences making up this family are annotated as, or are similar to, Ly49 receptors (e.g. Swiss:P20937). These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function  . They are members of the C-type lectin receptor superfamily  , and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (Pfam:PF00059).. 
+PF08392 FAE1/Type III polyketide synthase-like protein<br>Pfam-B_1177 (release 18.0). The members of this family are described as 3-ketoacyl-CoA synthases, type III polyketide synthases, fatty acid elongases and fatty acid condensing enzymes, and are found in both prokaryotic and eukaryotic (mainly plant) species. The region featured in this family contains the active site residues, as well as motifs involved in substrate binding  .. 
+PF08393 Dynein heavy chain, N-terminal region 2<br>Pfam-B_3094 (release 18.0). Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (Pfam:PF08385) in many members of this family. No functions seem to have been attributed specifically to this region.. 
+PF08394 Archaeal TRASH domain<br>Pfam-B_18882 (release 17.0). This region is found in the C-terminus of a number of archaeal transcriptional regulators. It is thought to function as a metal-sensing regulatory module  .. 
+PF08395 7tm Chemosensory receptor<br>This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [1,2].. 
+PF08396 Spider toxin omega agatoxin/Tx1 family<br>Mondal S, Ramakumar S. The Tx1 family lethal spider neurotoxin induces excitatory  symptoms in mice  .. 
+PF08397 IRSp53/MIM homology domain<br>Pfam-B_4120 (release 18.0). The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent  .. 
+PF08398 Parvovirus coat protein VP1<br>Pfam-B_2198 (release 18.0). This is the N-terminal region of the Parvovirus VP1 coat protein. Also see Parvovirus coat protein VP2 (Pfam:PF00740).. 
+PF08399 VWA N-terminal<br>Pfam-B_2075 (release 18.0). This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, Pfam:PF00092) and Cache (Pfam:PF02743) domains.  It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits  .. 
+PF08400 Prophage tail fibre N-terminal<br>Pfam-B_3101 (release 18.0). This domain is found at the N-terminus of prophage tail fibre proteins.. 
+PF08401 Domain of unknown function (DUF1738)<br>Pfam-B_3014 (release 18.0). This region is found in a number of bacterial hypothetical proteins. Some members are annotated as being similar to replication primases, and in fact this region is often found together with the Toprim domain (Pfam:PF01751).. 
+PF08402 TOBE domain<br>Pfam-B_4178 (release 18.0). The TOBE domain   (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulphate (Swiss:P16676). Found in ABC transporters immediately after the ATPase domain. In this family a strong RPE motif is found at the presumed N-terminus of the domain.. 
+PF08403 Amino acid permease N-terminal<br>Pfam-B_3112 (release 18.0). This domain is found to the N-terminus of the amino acid permease domain (Pfam:PF00324) in metazoan Na-K-Cl cotransporters.. 
+PF08404 Baculoviridae P74 N-terminal<br>Pfam-B_3059 (release 18.0). This domain is found at the N-terminus of P74 occlusion-derived virus (ODV) envelope proteins which are required for oral infectivity.  The envelope proteins are found in baculoviruses which are insect pathogens.  The C-terminus of P74 is anchored to the membrane whereas the N-terminus is exposed to the virion surface.  Furthermore P74 is unusual for a virus envelope protein as it lacks an N-terminal localisation signal sequence  .\.   Also see Pfam:PF04583.. 
+PF08405 Viral polyprotein N-terminal<br>Pfam-B_4167 (release 18.0). This domain is found at the N-terminus of non-structural viral polyproteins of the Caliciviridae subfamily.. 
+PF08406 CbbQ/NirQ/NorQ C-terminal <br>Pfam-B_3065 (release 18.0). This domain is found at the C-terminus of proteins of the CbbQ/NirQ/NorQ family of proteins which play a role in the post-translational activation of Rubisco  .  It is also found in the Thauera aromatica TutH protein which is similar to the CbbQ/NirQ/NorQ family  , as well as in putative chaperones.  The ATPase family associated with various cellular activities (AAA) Pfam:PF07728 is found in the same bacterial and archaeal proteins as the domain described here.. 
+PF08407 Chitin synthase N-terminal<br>Pfam-B_1105 (release 18.0). This is the N-terminal domain of Chitin synthase (Pfam:PF01644).. 
+PF08408 DNA polymerase family B viral insert<br>Pfam-B_3028 (release 18.0). This viral domain is found between the exonuclease domain of the DNA polymerase family B (Pfam:PF03104) and the Pfam:PF00136 domain, connecting the two.. 
+PF08409 Domain of unknown function (DUF1736)<br>Pfam-B_4104 (release 18.0). This domain of unknown function is found in various hypothetical metazoan proteins.. 
+PF08410 Domain of unknown function (DUF1737)<br>Pfam-B_2030 (release 18.0). This domain of unknown function is found at the N-terminus of bacterial and viral hypothetical proteins.. 
+PF08411 Exonuclease C-terminal<br>Pfam-B_3061 (release 18.0). This bacterial domain is found at the C-terminus of Exodeoxyribonuclease I/Exonuclease I (Pfam:PF00929), which is a single-strand specific DNA nuclease affecting recombination and expression pathways.  The exonuclease I protein in E. coli is associated with DNA deoxyribophosphodiesterase (dRPase)  .. 
+PF08412 Ion transport protein N-terminal<br>Pfam-B_4115 (release 18.0). This metazoan domain is found to the N-terminus of Pfam:PF00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.. 
+PF08414 Respiratory burst NADPH oxidase<br>Pfam-B_2127 (release 18.0). This domain is found in plant proteins such as respiratory burst NADPH oxidase proteins which produce reactive oxygen species as a defence mechanism.  It tends to occur to the N-terminus of an EF-hand (Pfam:PF00036), which suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants  .. 
+PF08415 Nonribosomal peptide synthase<br>Pfam-B_1156 (release 18.0). This domain is found in bacterial nonribosomal peptide synthetases (NRPS).  NRPS are megaenzymes organised as iterative modules, one for each amino acid to be built into the peptide product  . NRPS modules are involved in epothilone biosynthesis (EpoB), myxothiazol biosynthesis (MtaC and MtaD), and other functions  .  The NRPS domain tends to be found together with the condensation domain (Pfam:PF00668) and the phosphopantetheine binding domain (Pfam:PF00550).. 
+PF08416 Phosphotyrosine-binding domain<br>Pfam-B_3174 (release 18.0). The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus.  Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix).  Human tensin has actin-binding sites, an SH2 (Pfam:PF00017) domain and a region similar to the tumour suppressor PTEN  .  The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif  .. 
+PF08417 Pheophorbide a oxygenase<br>Pfam-B_3102 (release 18.0). This domain is found in bacterial and plant proteins to the C-terminus of a Rieske 2Fe-2S domain (Pfam:PF00355).  One of the proteins the domain is found in is Pheophorbide a oxygenase (PaO) which seems to be a key regulator of chlorophyll catabolism. Arabidopsis PaO (AtPaO) is a Rieske-type 2Fe-2S enzyme that is identical to Arabidopsis accelerated cell death 1 and homologous to lethal leaf spot 1 (LLS1) of maize  , in which the domain described here is also found.. 
+PF08418 DNA polymerase alpha subunit B N-terminal<br>Pfam-B_4046 (release 18.0). This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation  .  Also see Pfam:PF04058.. 
+PF08421 Putative zinc binding domain<br>Pfam-B_2038 (release 18.0). This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.. 
+PF08423 Rad51<br>Pfam-B_684 (release 17.0). Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.. 
+PF08424 DUF1740;<br>NRDE-2, necessary for RNA interference. Pfam-B_21376 (release 17.0). This is a family of eukaryotic proteins.  Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA  .. 
+PF08426 ICE2<br>ICE2 is a fungal ER protein which has been shown to play an important role in forming/maintaining the cortical ER  .  It has also bee identified as a protein which is necessary for nuclear inner membrane targeting  .. 
+PF08427 Domain of unknown function (DUF1741)<br>Pfam-B_35314 (release 17.0). This is a eukaryotic domain of unknown function.. 
+PF08428 Rib/alpha-like repeat<br>Pfam-B_3139 (release 18.0). The region featured in this family is found repeated in a number of bacterial surface proteins, such as Rib (Swiss:P72362) and alpha (Swiss:Q02192). These are expressed by group B streptococci, and Rib is thought to confer protective immunity.. 
+PF08429 PLU-1-like protein<br>Pfam-B_4023 (release 18.0). Sequences in this family bear similarity to the central region of PLU-1 (Swiss:Q9Y3Q5). This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer  . This region is found in various other Jumonji/ARID domain-containing proteins (see Pfam:PF02373, Pfam:PF01388).. 
+PF08430 Forkhead N-terminal region<br>Pfam-B_3191 (release 18.0). The region described in this family is found towards the N-terminus of various eukaryotic fork head/HNF-3-related transcription factors (which contain the Pfam:PF00250 domain). These proteins play key roles in embryogenesis, maintenance of differentiated cell states, and tumorigenesis  .. 
+PF08432 DUF1742;<br>AAA-ATPase Vps4-associated protein 1. Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole  .  There is a CCCH zinc finger at the N-terminus.. 
+PF08433 Chromatin associated protein KTI12 <br>Pfam-B_11625 (release 17.0). This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II  .  The Elongator complex has histone acetyltransferase activity.. 
+PF08434 Calcium-activated chloride channel<br>Pfam-B_3091 (release 18.0). The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells   and has four or five putative transmembrane regions.  Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors  .  The domain described here is found at the N-terminus of CLCAs.. 
+PF08435 Calici_coat_N; <br>Calicivirus coat protein C-terminal. Pfam-B_108 (release 18.0). This is the calicivirus coat protein (Pfam:PF00915) C-terminal region.. 
+PF08436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal<br>Pfam-B_445 (release 18.0). This domain is found to the C-terminus of Pfam:PF02670 domains in bacterial and plant 1-deoxy-D-xylulose 5-phosphate reductoisomerases which catalyse the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH  .. 
+PF08437 Glyco_transf_8N;<br>Glycosyl transferase family 8 C-terminal. Pfam-B_3038 (release 18.0). This domain is found at the C-terminus of the Pfam: PF01501 domain in bacterial glucosyltransferase and galactosyltransferase proteins.. 
+PF08438 GTPase of unknown function C-terminal<br>Pfam-B_4095 (release 18.0). This domain is found at the C-terminus of Pfam:PF01926 in archaeal and eukaryotic GTP-binding proteins. The C-terminal domain of the GTP-binding proteins is necessary for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotides.. 
+PF08439 Oligopeptidase F<br>Pfam-B_679 (release 18.0). This domain is found to the N-terminus of the Pfam:PF01432 domain in bacterial and archaeal proteins including Oligoendopeptidase F.  An example of this protein is Lactococcus lactis PepF  .. 
+PF08440 Potyviridae polyprotein<br>Pfam-B_237 (release 18.0). This domain is found in polyproteins of the viral Potyviridae taxon.. 
+PF08441 Integrin alpha<br>Pfam-B_609 (release 18.0). This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.. 
+PF08442 ATP-grasp domain<br>
+PF08443 RimK-like ATP-grasp domain<br>This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK  .. 
+PF08444 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region<br>Pfam-B_7828 (release 9.0). This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.. 
+PF08445 FR47-like protein<br>Pfam-B_71946 (release 17.0). The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47 (Swiss:Q9VR51). This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.. 
+PF08446 PAS fold<br>Pfam-B_437 (Release 18.0). The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs  . The PAS fold appears in archaea, eubacteria and eukarya.. 
+PF08447 PAS fold<br>Pfam-B_64 (Release 18.0). The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs  . The PAS fold appears in archaea, eubacteria and eukarya.. 
+PF08448 PAS fold<br>Pfam-B_493 (Release 18.0). The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs  . The PAS fold appears in archaea, eubacteria and eukarya.. 
+PF08449 UAA transporter family<br>Pfam-B_606 (release 18.0). This family includes transporters with a specificity for UDP-N-acetylglucosamine  .. 
+PF08450 SMP-30/Gluconolaconase/LRE-like region<br>Pfam-B_3630 (release 7.0). This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30, Swiss:Q15493), gluconolactonase (Swiss:Q01578) and luciferin-regenerating enzyme (LRE, Swiss:Q86DU5). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 (Swiss:P52430) and LRE  .. 
+PF08451 Adenosine/AMP deaminase N-terminal<br>Pfam-B_3145 (release 18.0). This domain is found to the N-terminus of the Adenosine/AMP deaminase domain (Pfam:PF00962) in metazoan proteins such as the Cat eye syndrome critical region protein 1 and its homologues.. 
+PF08452 DNA polymerase family B exonuclease domain, N-terminal<br>Pfam-B_3196 (release 18.0). This domain is found in viral DNA polymerases to the N-terminus of DNA polymerase family B exonuclease domains (Pfam:PF03104).. 
+PF08453 Peptidase family M9 N-terminal<br>Pfam-B_4156 (release 18.0). This domain is found in microbial collagenase metalloproteases to the N-terminus of Pfam:PF01752.  . 
+PF08454 RyR and IP3R Homology associated<br>Pfam-B_4135 (release 18.0). This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels  .  There seems to be no known function for this domain  . Also see the IP3-binding domain Pfam:PF01365 and Pfam:PF02815.. 
+PF08455 Bacterial SNF2 helicase associated<br>Pfam-B_3199 (release 18.0). This domain is found in bacterial proteins of the SWF/SNF/SWI helicase family to the N-terminus of the SNF2 family N-terminal domain (Pfam:PF00176) and together with the Helicase conserved C-terminal domain (Pfam:PF00271). The function of the domain is not clear  .. 
+PF08456 Viral methyltransferase C-terminal<br>Pfam-B_2153 (release 18.0). This domain is found to the C-terminus of the viral methyltransferase domain (Pfam:PF01660) in single-stranded-RNA positive-strand viruses with no DNA stage in the Virgaviridae family.. 
+PF08457 Sfi1 spindle body protein<br>Pfam-B_54813 (release 17.0). This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins   which are present in microtubule-organising centres.. 
+PF08458 Plant pleckstrin homology-like region<br>Pfam-B_7298 (release 8.0). This family describes a pleckstrin homology (PH)-like region found in several plant proteins of unknown function.. 
+PF08459 UvrC Helix-hairpin-helix N-terminal<br>Pfam-B_288 (release 18.0). This domain is found in the C subunits of the bacterial and archaeal UvrABC system which catalyses nucleotide excision repair in a multi-step process.  UvrC catalyses the first incision on the fourth or fifth phosphodiester bond 3' and on the eighth phosphodiester bond 5' from the damage that is to be excised  . The domain described here is found to the N-terminus of a helix hairpin helix (Pfam:PF00633) motif and also co-occurs with the Pfam:PF01541 catalytic domain which is found at the N-terminus of the same proteins.. 
+PF08460 Bacterial SH3 domain<br>Pfam-B_1108 (Release 18.0). 
+PF08462 Carmovirus coat protein<br>Pfam-B_4180 (release 18.0). This domain is found to the C-terminus of the Pfam:PF00729 domain in Carmoviruses.. 
+PF08463 EcoEI R protein C-terminal<br>Pfam-B_4136 (release 18.0). The restriction enzyme EcoEI recognises 5'-GAGN(7)ATGC-3' and is composed of the three proteins R, M, and S. The domain described here is found at the C-terminus of the R protein (HsdR) which is required for both nuclease and ATPase activity [1,2].. 
+PF08464 Geminivirus AC4/5 conserved region<br>Pfam-B_4177 (release 18.0). This domain is found in replication initiator (Rep) associated proteins such as AC5 in the Geminivirus/Begomovirus.. 
+PF08465 Thymidine kinase from Herpesvirus C-terminal<br>Pfam-B_4030 (release 18.0). This domain is found towards the C terminus in Herpesvirus Thymidine kinases.. 
+PF08466 Inward rectifier potassium channel N-terminal<br>Pfam-B_4080 (release 18.0). This metazoan domain is found to the N-terminus of the Pfam:PF01007 domain in Inward rectifier potassium channels (KIR2 or IRK2).. 
+PF08467 Luteovirus RNA polymerase P1-P2/replicase<br>Pfam-B_4011 (release 18.0). This domain is found in RNA-dependent RNA polymerase P1-P2 fusion/replicase proteins in plant Luteoviruses.. 
+PF08468 Methyltransferase small domain N-terminal<br>Pfam-B_4172 (release 18.0). This domain is found to the N-terminus of the methyltransferase small domain (Pfam:PF05175) in bacterial proteins  .. 
+PF08469 Nucleoside triphosphatase I C-terminal<br>Pfam-B_4183 (release 18.0). This viral domain is found to the C-terminus of Poxvirus nucleoside triphosphatase phosphohydrolase I (NPH I,  ) together with the helicase conserved C-terminal domain (Pfam:PF00271).. 
+PF08470 Nontoxic nonhaemagglutinin C-terminal<br>Pfam-B_4024 (release 18.0). Bacteria of the Clostridium genus produce protein neurotoxins, which are complexes consisting of neurotoxin (NT), haemagglutinin (HA), nontoxic nonhaemagglutinin (NTNH), and RNA [1, 2].  The domain described here is found at the C-terminus of the NTNH component.. 
+PF08471 Class II vitamin B12-dependent ribonucleotide reductase<br>Pfam-B_4121 (release 18.0). This domain is found to the N-terminus of the ribonucleotide reductase barrel domain (Pfam:PF02867).  It occurs in bacterial class II ribonucleotide reductase proteins which depend upon coenzyme B12 (deoxyadenosylcobalamine)  .. 
+PF08472 Sucrose-6-phosphate phosphohydrolase C-terminal<br>Pfam-B_4159 (release 18.0). This is the Sucrose-6-phosphate phosphohydrolase (S6PP or SPP) C-terminal domain   as found in in plant sucrose phosphatases. These enzymes irreversibly catalyse the last step in sucrose synthesis following the formation of Sucrose-6-Phosphate via sucrose-phosphate synthase (SPS).. 
+PF08473 Neuronal voltage-dependent calcium channel alpha 2acd<br>Pfam-B_4072 (release 18.0). This eukaryotic domain has been found in the neuronal voltage-dependent calcium channel (VGCC) alpha 2a, 2c, and 2d subunits.\.  It is also found in other calcium channel alpha-2 delta subunits to the N-terminus of a Cache domain (Pfam:PF02743).. 
+PF08474 Myelin transcription factor 1<br>Pfam-B_4029 (release 18.0). This domain is found in the myelin transcription factor 1 (MYT1) of chordates.  MYT1 contains C2HC zinc finger domains (Pfam:PF01530) and is expressed in developing neurons of the central nervous system   where it is involved in the selection of neuronal precursor cells  .. 
+PF08461 Ribonuclease R winged-helix domain<br>N-terminus of DUF128 family. This domain is found at the amino terminus of Ribonuclease R and a number of presumed transcriptional regulatory proteins from archaebacteria.. 
+PF08475 Viral capsid protein 91 N-terminal<br>Pfam-B_4034 (release 18.0). This domain is found in Baculoviridae including the nucleopolyhedrovirus at the N-terminus of the viral capsid protein 91 (VP91)  .. 
+PF08476 Viral D10 N-terminal<br>Pfam-B_4155 (release 18.0). This domain is found on the N-terminus of the viral protein D10 (VD10) and the related MutT motif proteins  .  The VD10 protein is probably essential for virus replication   and is often found to the N-terminus of a Pfam:PF00293 domain.. 
+PF08477 Miro-like protein<br>Pfam-B_1154 (release 17.0). Mitochondrial Rho proteins (Miro-1, Swiss:Q8IXI2, and Miro-2, Swiss:Q8IXI1), are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (Pfam:PF00036), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis   .. 
+PF08478 POTRA domain, FtsQ-type<br>Pfam-B_1605 (release 7.0). FtsQ/DivIB bacterial division proteins (Pfam:PF03799) contain an N-terminal POTRA domain (for polypeptide-transport-associated domain). This is found in different types of proteins, usually associated with a transmembrane beta-barrel. FtsQ/DivIB may have chaperone-like roles, which has also been postulated for the POTRA domain in other contexts  .. 
+PF08479 POTRA domain, ShlB-type<br>The POTRA domain (for polypeptide-transport-associated domain) is found towards the N-terminus of ShlB family proteins (Pfam:PF03865). ShlB is important in the secretion and activation of the haemolysin ShlA. It has been postulated that the POTRA domain has a chaperone-like function over ShlA; it may fold back into the C-terminal beta-barrel channel  .. 
+PF08480 Disaggregatase related<br>Pfam-B_4000 (release 18.0). This domain is found in disaggregatases and several hypothetical proteins of the archaeal genus Methanosarcina. Disaggregatases cause aggregates to separate into single cells   and contain parallel beta-helix repeats.  Also see Pfam:PF06848.. 
+PF08481 GBS Bsp-like repeat<br>Pfam-B_2122 (release 18.0). This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp.  Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology  .. 
+PF08482 ATP-dependent helicase C-terminal<br>Pfam-B_2170 (release 18.0). This domain is found near the C-terminus of bacterial ATP-dependent helicases such as HrpB.. 
+PF08483 IstB_N;<br>IstB-like ATP binding N-terminal. Pfam-B_3188 (release 18.0). This bacterial domain is found to the N-terminus of the Pfam:PF01695 like ATP binding domain in proteins which are putative transposase subunits  .. 
+PF08484 C-methyltransferase C-terminal domain<br>Pfam-B_2106 (release 18.0). This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as Pfam:PF08241 or Pfam:PF08242. But this domain is not a methyltransferase.. 
+PF08485 Polysaccharide biosynthesis protein C-terminal<br>Pfam-B_4073 (release 18.0). This domain is found to the C-terminus of the Pfam:PF02719 domain in bacterial polysaccharide biosynthesis enzymes including the capsule protein CapD   and several putative epimerases/dehydratases.. 
+PF08486 Stage II sporulation protein<br>Pfam-B_1108 (release 18.0). This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation  .  The domain is also found in amidase enhancer proteins.  Amidases, like SpoIID, are cell wall hydrolases  .. 
+PF08487 Vault protein inter-alpha-trypsin domain<br>Pfam-B_2015 (release 18.0). Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition  .  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.. 
+PF08488 Wall-associated kinase<br>Pfam-B_4138 (release 18.0). This domain is found together with the eukaryotic protein kinase domain Pfam:PF00069 in plant wall-associated kinases (WAKs) and related proteins.\.     WAKs are serine-threonine kinases which might be involved in signalling to the cytoplasm and are required for cell expansion  .. 
+PF08489 Domain of unknown function (DUF1743)<br>Pfam-B_4001 (release 18.0). This domain of unknown function is found in many hypothetical proteins and predicted DNA-binding proteins such as transcription-associated proteins.  It is found in bacteria and archaea.. 
+PF08490 Domain of unknown function (DUF1744)<br>Pfam-B_5917 (release 18.0). This domain is found on the epsilon catalytic subunit of DNA polymerase.  It is found C terminal to Pfam:PF03104 and Pfam:PF00136.. 
+PF08491 Squalene epoxidase<br>Pfam-B_3107 (release 18.0). This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.\.       SE was first cloned from Saccharomyces cerevisiae where it was named ERG1.  It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway  .  Putative transmembrane regions are found to the protein's C-terminus.. 
+PF08492 SRP72 RNA-binding domain<br>Pfam-B_7529 (Release 18.0). This region has been identified as the binding site of the SRP72 protein to SRP RNA  .. 
+PF08493 Aflatoxin regulatory protein<br>Pfam-B_2081 (release 18.0). This domain is found in the aflatoxin regulatory protein (AflR) which is involved in the regulation of the biosynthesis of aflatoxin in the fungal genus Aspergillus  .  It occurs together with the fungal Zn(2)-Cys(6) binuclear cluster domain (Pfam:PF00172).. 
+PF08494 DEAD/H associated<br>Pfam-B_4150 (release 18.0). This domain is found in ATP-dependent helicases as well as a number of hypothetical proteins together with the helicase conserved C-terminal domain (Pfam:PF00270) and the Pfam:PF00271 domain.. 
+PF08495 DUF1745; <br>The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids  .. 
+PF08496 Peptidase family S49 N-terminal<br>Pfam-B_4027 (release 18.0). This domain is found to the N-terminus of bacterial signal peptidases of the S49 family (Pfam:PF01343) [1,2].. 
+PF08497 Radical SAM N-terminal<br>Pfam-B_2018 (release 18.0). This domain tends to occur to the N-terminus of the Pfam:PF04055 domain in hypothetical bacterial proteins.. 
+PF08498 Sterol methyltransferase C-terminal<br>Pfam-B_3143 (release 18.0). This domain is found to the C-terminus of a methyltransferase domain (Pfam:PF08241) in fungal and plant sterol methyltransferases  .. 
+PF08499 3'5'-cyclic nucleotide phosphodiesterase N-terminal<br>Pfam-B_3045 (release 18.0). This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (Pfam:PF00233).. 
+PF08500 Tombusvirus p33 <br>Pfam-B_2139 (release 18.0). Tombusviruses, which replicate in a wide range of plant hosts, replicate with the help of viral replicase protein including the overlapping p33 and p92 proteins which contain the domain described here  .. 
+PF08501 Shikimate dehydrogenase substrate binding domain<br>Pfam-B_99 (release 18.0). This domain is the substrate binding domain of shikimate dehydrogenase  .. 
+PF08502 LeuA allosteric (dimerisation) domain<br>Pfam-B_223 (release 18.0). This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway  .\.      This domain, is an internally duplicated structure with a novel fold  . It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich  .. 
+PF08503 DapD_N;<br>Tetrahydrodipicolinate succinyltransferase N-terminal. Pfam-B_4065 (release 18.0). This domain is found at the N-terminus of tetrahydrodipicolinate N-succinyltransferase (DapH) which catalyses the acylation of L-2-amino-6-oxopimelate to 2-N-succinyl-6-oxopimelate in the meso-diaminopimelate/lysine biosynthetic pathway of bacteria, blue-green algae, and plants  . The N-terminal domain as defined here contains three alpha-helices and two twisted hairpin loops  .. 
+PF08504 Runx inhibition domain<br>Pfam-B_4085 (release 18.0). This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2).  Its function might be to interact with functional cofactors  .. 
+PF08505 DSL1;<br>Mitochondrial Myo2 receptor-related protein. Myo2p, a class V myosin, is essential for mitochondrial distribution, class V being vital for organelle distribution in S. cerevisiae. It is the myosin essential for mitochondrial distribution. The established mechanism for distribution of cellular components by class V myosins is that they interact with the cargo at the C-terminal tail domain and transport it along the actin cytoskeleton using the N-terminal motor domain. Cargo-specific myosin receptors act as the link between the myosin tail and cargo. Myo2 binds with MMR1 (mitochondrial Myo2p receptor-related 1), the receptor on cargo, via the C-terminal domain.. 
+PF08506 Cse1<br>Pfam-B_9217 (release 17.0). This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha.  This domain contains HEAT repeats  .. 
+PF08507 COPI associated protein<br>Proteins in this family colocalise with COPI vesicle coat proteins  .. 
+PF08508 Fungal domain of unknown function (DUF1746)<br>This is a fungal domain of unknown function.. 
+PF08509 Adenylate cyclase G-alpha binding domain<br>This fungal domain is found in adenylate cyclase and interacts with the alpha subunit of heterotrimeric G proteins  .. 
+PF08510 PIG-P<br>PIG-P (phosphatidylinositol N-acetylglucosaminyltransferase subunit P) is an enzyme involved in GPI anchor biosynthesis  .. 
+PF08511 COQ9<br>COQ9 is an enzyme that is required for the biosynthesis of coenzyme Q  .  It may either catalyse a reaction in the coenzyme Q biosynthetic pathway or have a regulatory role.. 
+PF08512 DUF1747; <br>Histone chaperone Rttp106-like. This family includes Rttp106, a histone chaperone involved in heterochromatin-mediated silencing  . This domain belongs to the Pleckstrin homology domain superfamily.. 
+PF08513 LisH<br>Pfam-B_8344 (release 17.0). The LisH (lis homology) domain mediates protein dimerisation and tetramerisation.  The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes.  It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex  .. 
+PF08514 STAG domain  <br>Pfam-B_4766 (release 17.0). STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organisms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version  .. 
+PF08515 Transforming growth factor beta type I GS-motif<br>Pfam-B_630 (release 18.0). This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation.  The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain.  Point mutations in the GS motif modify the signaling ability of the type I receptor  .. 
+PF08516 ADAM cysteine-rich<br>Pfam-B_197 (release 18.0). ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour.  It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity  .. 
+PF08517 Ataxin-1 and HBP1 module (AXH)<br>Pfam-B_5484 (release 18.0). AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1).  ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans.  The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression  .. 
+PF08518 Spa2 homology domain (SHD) of GIT<br>Pfam-B_13873 (release 18.0). GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ).  The function of the CAZ might be to define sites of neurotransmitter release.  Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase  .. 
+PF08519 Replication factor RFC1 C terminal domain<br>Pfam-B_5399 (release 17.0). This is the C terminal domain of replication factor C, RFC1.  RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo   .. 
+PF08520 Fungal protein of unknown function (DUF1748)<br>This is a family of fungal proteins of unknown function.. 
+PF08521 Two-component sensor kinase N-terminal<br>Pfam-B_4164 (release 18.0). This domain is found in bacterial two-component sensor kinases towards the N-terminus.. 
+PF08522 Domain of unknown function (DUF1735)<br>Pfam-B_2199 (release 18.0). This domain of unknown function is found in a number of bacterial proteins including acylhydrolases.. 
+PF08523 Multiprotein bridging factor 1<br>Pfam-B_4141 (release 18.0). This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2.  It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex  . It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC  .  The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants.\.      A helix-turn-helix motif (Pfam:PF01381) is found to its C-terminus.. 
+PF08524 rRNA processing<br>This is a family of proteins that are involved in rRNA processing  .  In a localisation study they were found to localise to the nucleus and nucleolus  . The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1  . In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli  .. 
+PF08525 Opacity-associated protein A N-terminal motif<br>This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1,2]. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.. 
+PF08526 Protein-arginine deiminase (PAD) N-terminal domain<br>Pfam-B_2195 (release 6.4). This family represents the N-terminal non-catalytic domain of protein-arginine deiminase. This domain has a cupredoxin-like fold.. 
+PF08527 Protein-arginine deiminase (PAD) middle domain<br>Pfam-B_2195 (release 6.4). This family represents the central non-catalytic domain of protein-arginine deiminase. This domain has an immunoglobulin-like fold.. 
+PF08528 Nrm1; <br>In metazoans, cyclin-dependent kinase(CDK) dependent phosphorylation of the retinoblastoma Tudor suppressor protein (Rb) alleviates repression of E2F and thereby activates G1/S transcription. The cell size regulator Whi5 appears to be an analogous target of CDK activity during G1 phase  .. 
+PF08529 NusA N-terminal domain<br>Pfam-B_407 (Release 18.0). This domain represents the RNA polymerase binding domain of NusA.. 
+PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain<br>This domain contains a beta sandwich domain.. 
+PF08531 Alpha-L-rhamnosidase N-terminal domain<br>Pfam-B_8527 (release 8.0). This family consists of bacterial rhamnosidase A and B enzymes. This domain is probably involved in substrate recognition.. 
+PF08532 Beta-galactosidase trimerisation domain<br>Pfam-B_2131 (release 5.4). This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation  .. 
+PF08533 Beta-galactosidase C-terminal domain<br>Pfam-B_2131 (release 5.4). This domain is found at the C-terminus of beta-galactosidase enzymes that belong to the glycosyl hydrolase 42 family  .. 
+PF08535 KorB domain<br>Pfam-B_20369 (release 10.0). This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon  . This domain includes the DNA-binding HTH motif  .. 
+PF08536 Plant_TF; <br>Whirly transcription factor. Mistry J, Pachon DMR. This family contains the plant whirly transcription factors.. 
+PF08537 Fungal Nap binding protein NBP1<br>NBP1 is a nuclear protein which has been shown in Saccharomyces cerevisiae to be essential for the G2/M transition of the cell cycle.. 
+PF08538 Protein of unknown function (DUF1749)<br>This is a plant and fungal family of unknown function.  This family contains many hypothetical proteins.. 
+PF08539 HbrB-like<br>HbrB is involved hyphal growth and polarity  .. 
+PF08540 Hydroxymethylglutaryl-coenzyme A synthase C terminal<br>
+PF08541 ACP_C; <br>3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal  . Pfam-B_67 (release 18.0). This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.41, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.. 
+PF08542 Replication factor C C-terminal domain<br>Pfam-B_930 (release 18.0). This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA).  The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A  .. 
+PF08543 Phosphomethylpyrimidine kinase<br>Pfam-B_787 (release 18.0). This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes  .. 
+PF08544 GHMP kinases C terminal <br>This family includes homoserine kinases, galactokinases and mevalonate kinases.. 
+PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III<br>Pfam-B_135 (release 18.0). This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.180, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.. 
+PF08546 Ketopantoate reductase PanE/ApbA C terminal<br>Pfam-B_396 (release 18.0). This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169.  The reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway  .  ApbA and PanE are allelic  .  ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway  .. 
+PF08547 Complex I intermediate-associated protein 30 (CIA30)<br>This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits.\.  This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation   .. 
+PF08548 Peptidase M10 serralysin C terminal<br>Mistry J, Rawlings ND. Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs).\. The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain Pfam:PF00353.. 
+PF08549 DUF1750; SWI-SNF_ssr4; <br>Fungal domain of unknown function (DUF1750). This is a fungal domain of unknown function.. 
+PF08550 Fungal protein of unknown function (DUF1752)<br>This is a family of fungal proteins of unknown function. This short section domain is bounded by two highly conserved tryptophans. The family contains Swiss:P34072 that is thought to be a negative regulator of RAS-cAMP pathway in S.cerevisiae. the Sch.pombe member is a GAF1 transcription factor Swiss:Q10280 that is also associated with the zinc finger family GATA Pfam:PF00320.. 
+PF08551 Eukaryotic integral membrane protein (DUF1751)<br>Pfam-B_13217 (release 18.0). This domain is found in eukaryotic integral membrane proteins. Swiss:Q12239, a Saccharomyces cerervisiae protein, has been shown to localise COP II vesicles  .. 
+PF08552 DUF1753;<br>Inositolphosphorylceramide synthase subunit Kei1. Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase  . It is localised to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2  .  Kei1 is essential for both the activity and the Golgi localization of IPC synthase  .. 
+PF08553 VID27 cytoplasmic protein<br>This is a family of fungal and plant proteins and contains many hypothetical proteins.  VID27 is a cytoplasmic protein that plays a potential role in vacuolar protein degradation.. 
+PF08555 Eukaryotic family of unknown function (DUF1754)<br>Daub J, Mistry J, Wood V. Pfam-B_10536 (release 18.0). This is a eukaryotic protein family of unknown function.. 
+PF08557 Sphingolipid Delta4-desaturase (DES)<br>Daub J, Mistry J, Wood V. Pfam-B_9504 (release 18.0). Sphingolipids are important membrane signalling molecules involved in many different cellular functions in eukaryotes. Sphingolipid delta 4-desaturase catalyses the formation of (E)-sphing-4-enine  .  Some proteins in this family have bifunctional delta 4-desaturase/C-4-hydroxylase activity.  Delta 4-desaturated sphingolipids may play a role in early signalling required for entry into meiotic and spermatid differentiation pathways during Drosophila spermatogenesis  .  This small domain associates with FA_desaturase Pfam:PF00487 and appears to be specific to sphingolipid delta 4-desaturase.. 
+PF08558 Telomere repeat binding factor (TRF)<br>Pfam-B_8956 (release 18.0) . Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain Pfam:PF00249 at the carboxy terminus  . TRF1 is implicated in telomere length regulation and TRF2 in telomere protection  . Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres  . This domain is composed of multiple alpha helices   arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors  .. 
+PF08559 Cut8;<br>Cut8 six-helix bundle. Daub J, Wood V, Eberhardt R. In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome  . Cut8 comprises three functional domains. An N-terminal lysine-rich segment (Pfam:PF14482) which binds to the proteasome when ubiquitinated, a central dimerisation domain (Pfam:PF14483) and a C-terminal six-helix bundle (this entry), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding  . Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8  . Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome  . In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1  . Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum  .. 
+PF08560 Protein of unknown function (DUF1757)<br>This family of proteins are about 150 amino acids in length and have no known function.. 
+PF08561 Mitochondrial ribosomal protein L37<br>This family includes yeast MRPL37 a mitochondrial ribosomal protein  .. 
+PF08562 Crisp<br>This domain is found on Crisp proteins which contain Pfam:PF00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling  . It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK  .. 
+PF08563 P53 transactivation motif<br>Pfam-B_3515 (release 19.0). The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation.  This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence [1-2].. 
+PF08564 Cdc37;<br>Cdc37 C terminal domain. Pfam-B_3345 (release 6.5). Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the C terminal domain whose function is unclear.  It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain Pfam:PF08565 and the N terminal kinase binding domain of Cdc37 Pfam:PF03234  .. 
+PF08565 Cdc37;<br>Cdc37 Hsp90 binding domain. Pfam-B_3345 (release 6.5). Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37  .  It is found between the N terminal Cdc37 domain Pfam:PF03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 Pfam:PF08564 whose function is unclear.. 
+PF08566 Mitochondrial import protein Pam17<br>The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix.  The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase  . Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins  .. 
+PF08567 TFIIH p62 subunit, N-terminal domain<br>Pfam-B_31040 (release 19.0). The N-terminal domain of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity.  The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal domain reveals that it adopts a pleckstrin homology (PH) fold [1,2].. 
+PF08568 DUF1760; <br>Uncharacterised protein family, YAP/Alf4/glomulin. Mistry J, Wood V, Lonsdale D. This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS) [1,2]. The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation    . The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12 [4,5].. 
+PF08569 Mo25-like<br>Pfam-B_5502 (release 18.0). Mo25-like proteins are involved in both polarised growth and cytokinesis.  In fission yeast Mo25 is localised alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner [1,2].. 
+PF08570 Protein of unknown function (DUF1761)<br>Pfam-B_85869 (release 19.0). Family of conserved fungal and bacterial membrane proteins with unknown function.. 
+PF08571 Yos1-like<br>Pfam-B_23321 (release 19.0). In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Yos1 appears to be conserved in eukaryotes .. 
+PF08572 pre-mRNA processing factor 3 (PRP3)<br>Pfam-B_7232 (release 18.0). Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor.  The human PRP3 has been implicated in autosomal retinitis pigmentosa  .. 
+PF08573 DNA repair protein endonuclease SAE2/CtIP C-terminus<br>SAE2 is a protein involved in repairing meiotic and mitotic double-strand breaks in DNA.  It has been shown to negatively regulate DNA damage checkpoint signalling   . SAE2 is homologous to the CtIP proteins in mammals and an homologous protein in plants. Crucial sequence motifs that are highly conserved are the CxxC and the RHR motifs in this C-terminal part of the protein  . It is now known to be an endonuclease. In budding yeast, genetic evidence suggests that the SAE2 protein is essential for the processing of hairpin DNA intermediates and meiotic double-strand breaks by Mre11/Rad50 complexes. SAE2 binds DNA and exhibits endonuclease activity on single-stranded DNA independently of Mre11/Rad50 complexes, but hairpin DNA structures are cleaved cooperatively in the presence of Mre11/Rad50 or Mre11/Rad50/Xrs2.  Hairpin structures are not processed at the tip by SAE2 but rather at single-stranded DNA regions adjacent to the hairpin. The catalytic activities of SAE2 are important for its biological functions  .. 
+PF08574 Protein of unknown function (DUF1762)<br>This is a family of proteins of unknown function.\.     Swiss:Q07532 is known to interact with RNA polymerase II and deletion of this protein results in hypersensitivity to the K1 killer toxin  .. 
+PF08576 Eukaryotic protein of unknown function (DUF1764)<br>This is a family of eukaryotic proteins of unknown function. This family contains many hypothetical proteins.. 
+PF08577 PI31_Prot_Reg;<br>PI31 proteasome regulator . PI31 is a cellular regulator of proteasome formation and of proteasome-mediated antigen processing  .. 
+PF08578 Protein of unknown function (DUF1765)<br>This region represents a conserved region found in hypothetical proteins from fungi, mycetozoa and entamoebidae.. 
+PF08579 Mitochondrial ribonuclease P subunit (RPM2)<br>Ribonuclease P (RNase P) generates mature tRNA molecules by cleaving their 5' ends.  RPM2 is a protein subunit of the yeast mitochondrial RNase P.  It has the ability to act as transcriptional activator in the nucleus where it plays a role in defining the steady-state levels of mRNAs for some nucleus-encoded mitochondrial components  .. 
+PF08580 Yeast cortical protein KAR9<br>The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules  . KAR9 localises at the shmoo tip in mating cells and at the tip of the growing bud in anaphase  .. 
+PF08581 Tup N-terminal<br>Pfam-B_9595 (release 19.0). The N-terminal domain of the Tup protein has been shown to interact with the Ssn6 transcriptional co-repressor  .. 
+PF08583 UPF0287; <br>Cytochrome c oxidase biogenesis protein Cmc1 like. Cmc1 is a metallo-chaperone like protein which is known to localise to the inner mitochondrial membrane in Saccharomyces cerevisiae.  It is essential for full expression of cytochrome c oxidase and respiration  .  Cmc1 contains two Cx9C motifs and is able to bind copper(I).  Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase  .. 
+PF08584 Ribonuclease P 40kDa (Rpp40) subunit<br>The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex  .. 
+PF08585 Domain of unknown function (DUF1767)<br>Eukaryotic domain of unknown function.  This domain is found to the N-terminus of the nucleic acid binding domain.. 
+PF08586 RSC complex, Rsc14/Ldb7 subunit<br>RSC is an ATP-dependent chromatin remodelling complex found in yeast. The RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions  .. 
+PF08587 Ubiquitin associated domain (UBA) <br>Pfam-B_10238 (Release 18.0). This is a UBA (ubiquitin associated) domain  .  Ubiquitin is involved in intracellular proteolysis.. 
+PF08588 Protein of unknown function (DUF1769)<br>Family of fungal protein with unknown function.. 
+PF08589 Fungal protein of unknown function (DUF1770)<br>The function of this family is unknown. These proteins are rather dissimilar except for a single strongly conserved motif (PDLRFEQ).. 
+PF08590 Domain of unknown function (DUF1771)<br>Pfam-B_10757 (release 18.0). This domain is always found adjacent to Pfam:PF01713.. 
+PF08591 Ribonucleotide reductase inhibitor<br>This family includes S. pombe Spd1. Spd1p inhibits fission yeast RNR activity by interacting with the Cdc22p  .. 
+PF08592 Domain of unknown function (DUF1772)<br>This domain is of unknown function.. 
+PF08593 DUF1773; <br>Meiotically up-regulated glycoproteins C-terminal. Pfam-B_26890 (release 18.0). This is the C-terminal part of some meiotically up-regulated gene products from fission yeast. The actual function is not yet known but the proteins are likely to be cell-surface glycoproteins.. 
+PF08594 Uncharacterised protein family (UPF0300)<br>Pfam-B_20198 (release 18.0). This family of proteins appear to be specific to S. pombe.. 
+PF08595 RXT2-like, N-terminal<br>The family represents the N-terminal region of RXT2-like proteins.  In S. cerevisiae, RXT2 has been demonstrated to be involved in conjugation with cellular fusion (mating) and invasive growth  .  A high throughput localisation study has localised RXT2 to the nucleus  .. 
+PF08596 Lethal giant larvae(Lgl) like, C-terminal<br>The Lethal giant larvae (Lgl) tumour suppressor family is conserved from yeast to mammals.  The Lgl family functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface  .  The N-terminal half of Lgl members contains WD40 repeats (see Pfam:PF00400), while the C-terminal half appears specific to the family  .. 
+PF08597 Translation initiation factor eIF3 subunit<br>This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3).  In yeast it is called Hcr1.  The Saccharomyces cerevisiae protein Swiss:Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p   .. 
+PF08598 Sds3-like<br>Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins  .\.     This family represents the conserved region found in Sds3, Dep1 and BRMS1-homologue p40 proteins.. 
+PF08599 Nbs1_N; <br>DNA damage repair protein Nbs1. This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1   .. 
+PF08600 Rsm1-like<br>Rsm1 is a protein involved in mRNA export from the nucleus  . 
+PF08601 Transcription factor PAP1<br>Pfam-B_20528 (release 18.0). The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2  .  This region is cysteine rich.  Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression  .. 
+PF08602 Mgr1-like, i-AAA protease complex subunit<br>The S. cerevisiae Mgr1 protein has been shown to be required for mitochondrial viability in yeast lacking mitochondrial DNA. It is a mitochondrial inner membrane protein, which interacts with Yme1 and is a new subunit of the i-AAA protease complex  .. 
+PF08603 CAP;<br>Adenylate cyclase associated (CAP) C terminal. 
+PF08604 Nucleoporin Nup153-like<br>Pfam-B_56527 (release 19.0). This family contains both the nucleoporin Nup153 from human and Nup153 from fission yeast.  These have been demonstrated to be functionally equivalent  .. 
+PF08605 Fungal Rad9-like Rad53-binding<br>In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways.  DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 Pfam:PF00498 domains  . This region is structurally composed of a pair of TUDOR domains  .. 
+PF08606 Prp19/Pso4-like<br>Pfam-B_6384 (release 18.0). This regions is found specifically in PRP19-like protein.\.       The region represented by this family covers the sequence implicated in self-interaction and a coiled-coiled motif  .  PRP19-like proteins form an oligomer that is necessary for spliceosome assembly  .. 
+PF08534 Redoxin<br>This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins.. 
+PF08608 Wyosine base formation<br>Some proteins in this family appear to be important in wyosine base formation in a subset of phenylalanine specific tRNAs.  It has been proposed that they participates in converting tRNA(Phe)-m(1)G(37) to tRNA(Phe)-yW  .. 
+PF08609 Nucleotide exchange factor Fes1<br>Pfam-B_36022 (release 18.0). Fes1 is a cytosolic homologue of Sls1, an ER protein which has nucleotide exchange factor activity.  Fes1 in yeast has been shown to bind to the molecular chaperone Hsp70 and has adenyl-nucleotide exchange factor activity  .. 
+PF08610 Peroxisomal membrane protein (Pex16)<br>Pex16 is a peripheral protein located at the matrix face of the peroxisomal membrane  .. 
+PF08611 Fungal protein of unknown function (DUF1774)<br>This is a fungal family of unknown function.. 
+PF08612 TATA_RF; <br>TATA-binding related factor (TRF) of subunit 20 of Mediator complex. This family of proteins is related to TATA-binding protein (TBP). TBP is a highly conserved RNA polymerase II general transcription factor that binds to the core promoter and initiates assembly of the preinitiation complex.  Human TRF has been shown to associate with an RNA polymerase II-SRB complex  . This Med20 subunit of Mediator is found in the non-essential part of the head  .. 
+PF08613 Cyclin<br>Pfam-B_6792 (release 18.0). This family includes many different cyclin proteins.  Members include the G1/S-specific cyclin pas1  , and the phosphate system cyclin PHO80/PHO85  .. 
+PF08614 Autophagy protein 16 (ATG16)<br>Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells.\.       During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway  .. 
+PF08615 RNase_H1_sml;<br>Ribonuclease H2 non-catalytic subunit (Ylr154p-like). Pfam-B_36578 (release 18.0). This entry represents the non-catalytic subunit of RNase H2, which in S. cerevisiae is Ylr154p/Rnh203p Swiss:Q12338 (. Whereas bacterial and archaeal RNases H2 are active as single polypeptides, the Saccharomyces cerevisiae homologue, Rnh2Ap, when expressed in Escherichia coli, fails to produce an active RNase H2. For RNase H2 activity three proteins are required [Rnh2Ap (Rnh201p), Ydr279p (Rnh202p) and Ylr154p (Rnh203p)]. Deletion of any one of the proteins or mutations in the catalytic site in Rnh2A leads to loss of RNase H2 activity  . RNase H2 ia an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. It participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.. 
+PF08616 SPB_interacting;<br>Stabilization of polarity axis. Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body  . In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation  . and in S. cerevisiae it functions as a polarisation-specific docking factor  .. 
+PF08617 Kinase binding protein CGI-121<br>CGI-121 has been shown to bind to the p53-related protein kinase (PRPK)  .  PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation  .  Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.. 
+PF08618 Transcription factor Opi1<br>Opi1 is a leucine zipper containing yeast transcription factor that negatively regulates phospholipid biosynthesis  .  It represses the expression of several UAS(INO) cis acting element containing genes and its activity is mediated by phosphorylations catalysed by protein kinase A, protein kinase C and casein kinase II  .. 
+PF08619 Alkali metal cation/H+ antiporter Nha1 C terminus<br>The C terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an execessive loss of ions and water  .  This  domain is found with Pfam:PF00999.. 
+PF08620 RPAP1-like, C-terminal<br>Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11  .\.   This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.. 
+PF08621 RPAP1-like, N-terminal<br>Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11  .\.     This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.. 
+PF08622 Svf1-like<br>Family of proteins that are involved in survival during oxidative stress .. 
+PF08623 TATA-binding protein interacting (TIP20)<br>TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription  .. 
+PF08624 Chromatin remodelling complex Rsc7/Swp82 subunit<br>Pfam-B_56720 (release 18.0). This family has been identified as a subunit of chromatin remodelling complexes.  Saccharomyces cerevisiae Swiss:P32832 and its paralogue Swiss:P43554 have been identified as subunits of the RSC chromatin remodelling complex, and SWI/SNF chromatin remodelling complex respectively  .. 
+PF08625 Utp13 specific WD40 associated domain<br>Pfam-B_8625 (release 19.0). Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome  . Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end  .. 
+PF08626 Trs120;<br>Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit. Pfam-B_15686 (release 19.0). This region is found at the N terminal of Saccharomyces cerevisiae Trs120 protein (Swiss:Q04183).  Trs120 is a subunit of the multiprotein complex TRAPP (transport particle protein) which functions in ER to Golgi traffic  . Trs120 is specific to the larger TRAPP complex, TRAPP II, along with Trs65p and Trs130p(TRAPPC10). It is suggested that Trs120p is required for the stability of the Trs130p subunit, suggesting that these two proteins might interact in some way  . It is likely that there is a complex function for TRAPP II in multiple pathways  .. 
+PF08627 CRT-like<br>Pfam-B_67420 (release 18.0). This region is found in proteins related to Plasmodium falciparum chloroquine resistance transporter (CRT).. 
+PF08628 Sorting nexin C terminal<br>Pfam-B_5897 (release 19.0). This region is found a the C terminal of proteins belonging to the sorting nexin family.  It is found on proteins which also contain Pfam:PF00787.. 
+PF08629 PDE8 phosphodiesterase<br>Pfam-B_72889 (release 17.0). This region is found in members of the PDE8 phosphodiesterase family  .  It is found with Pfam:PF00233.. 
+PF08630 Dfp1/Him1, central region<br>Pfam-B_28140 (release 19.0). This is the middle regions described by Ogino et al  .  This region, together with the C-terminal zinc finger (Pfam:PF07535) is essential for the mitotic and kinase activation functions of Dfp1/Him1  .. 
+PF08631 Meiosis protein SPO22/ZIP4 like<br>SPO22/ZIP4 in yeast is a meiosis specific protein involved in sporulation  .  It has been shown to regulate crossover distribution by promoting synaptonemal complex formation  .. 
+PF08632 Zds1_C; <br>Activator of mitotic machinery Cdc14 phosphatase activation C-term. Pfam-B_44907 (release 19.0). This region of the Zds1 protein is critical for sporulation and has also been shown to suppress the calcium sensitivity of Zds1 deletions  . The C-terminal motif is common to both Zds1 and Zds2 proteins, both of which are putative interactors of Cdc55 and are required for the completion of mitotic exit and cytokinesis. They both contribute to timely Cdc14 activation during mitotic exit and are required downstream of separase to facilitate nucleolar Cdc14 release .. 
+PF08633 Rox3 mediator complex subunit<br>The mediator complex is part of the RNA polymerase II holoenzyme. Rox3 is a subunit of the mediator complex.. 
+PF08634 Mitochondrial protein Pet127<br>Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localised to the mitochondrial membrane  . The Pet127 family is part of the PD-(D/E)XK nuclease superfamily   including a full set of active site residues.. 
+PF08635 Putative oxidoreductase C terminal<br>This is the C terminal of a family of putative oxidoreductases.. 
+PF08636 ER protein Pkr1<br>Pkr1 has been identified as an ER protein of unknown function.. 
+PF08637 ATP synthase regulation protein NCA2<br>Pfam-B_15813 (release 19.0). NCA2 has been shown to be required for the regulation of ATP synthase subunits Atp6p and Atp8p in Saccharomyces cerevisiae  .. 
+PF08638 MED14; <br>Mediator complex subunit MED14. Pfam-B_13303 (release 19.0). Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation   .  This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator  .. 
+PF08639 DNA replication regulator SLD3<br>The SLD3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication  .. 
+PF08640 U3 small nucleolar RNA-associated protein 6<br>Pfam-B_8720 (release 19.0). This is a family of U3 nucleolar RNA-associated proteins which are involved in nucleolar processing of pre-18S ribosomal RNA  .. 
+PF08641 Kinetochore protein Mis14 like<br>Mis14 is a kinetochore protein which is known to be recruited to kinetochores independently of CENP-A  .. 
+PF08642 Histone deacetylation protein Rxt3<br>Rxt3 has been shown in yeast to be required for histone deacetylation  .. 
+PF08643 Fungal family of unknown function (DUF1776)<br>Mistry J, Groocock L. This is a fungal family of unknown function.  One of the proteins in this family Swiss:P32792 has been localised to the mitochondria  .. 
+PF08644 FACT complex subunit (SPT16/CDC68)<br>Pfam-B_4478 (release 19.0). Proteins in this family are subunits the FACT complex.  The FACT complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin  .. 
+PF08645 Polynucleotide kinase 3 phosphatase<br>Pfam-B_6220 (release 19.0). Polynucleotide kinase 3 phosphatases play a role in the repair of single breaks in DNA induced by DNA-damaging agents such as gamma radiation and camptothecin  . . 
+PF08646 Replication factor-A C terminal domain<br>Pfam-B_3457 (release 19.0). This domain is found at the C terminal of replication factor A. Replication factor A (RPA) binds single-stranded DNA and is involved in replication, repair, and recombination of DNA  .. 
+PF08647 BRE1 E3 ubiquitin ligase<br>Pfam-B_35727 (release 19.0). BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions  .. 
+PF08648 Protein of unknown function (DUF1777)<br>This is a family of eukaryotic proteins of unknown function. Some of the proteins in this family are putative nucleic acid binding proteins.. 
+PF08649 DASH complex subunit Dad1<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules  . Throughout the cell cycle Dad1 remains bound to kinetochores throughout the cell cycle and its association is dependent on the Mis6 and Mal2  .. 
+PF08650 DASH complex subunit Dad4<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].. 
+PF08651 DASH complex subunit Duo1<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].. 
+PF08652 RAI1 like PD-(D/E)XK nuclease<br>Pfam-B_13095 (release 19.0). 
+PF08653 DASH complex subunit Dam1<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules  . . 
+PF08654 DASH complex subunit Dad2<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].. 
+PF08655 DASH complex subunit Ask1<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules  . . 
+PF08656 DASH complex subunit Dad3<br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].. 
+PF08657 DASH complex subunit Spc34 <br>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis  . In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules  .. 
+PF08658 Rad54 N terminal<br>Pfam-B_26946 (release 19.0). This is the N terminal of the DNA repair protein Rad54  .. 
+PF08659 KR domain<br>This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group  .. 
+PF08660 Oligosaccharide biosynthesis protein Alg14 like<br>Pfam-B_12992 (release 19.0). Alg14 is involved dolichol-linked oligosaccharide biosynthesis and anchors the catalytic subunit Alg13 to the ER membrane  .. 
+PF08661 Replication factor A protein 3<br>Replication factor A is involved in eukaryotic DNA replication, recombination and repair.. 
+PF08662 Eukaryotic translation initiation factor eIF2A<br>Pfam-B_7957 (release 19.0). This is a family of eukaryotic translation initiation factors.. 
+PF08663 HalX domain<br>HalX is a domain of unknown function, previously (mis)annotated as HoxA-like transcriptional regulator.. 
+PF08664 YcbB domain<br>YcbB is a DNA-binding domain  .. 
+PF08665 PglZ domain<br>This family is a member of the Alkaline phosphatase clan.. 
+PF08666 SAF domain<br>This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins.. 
+PF08667 BetR domain<br>This family includes an N-terminal helix-turn-helix domain.. 
+PF08668 HDOD domain<br>
+PF08669 Glycine cleavage T-protein C-terminal barrel domain<br>Pfam-B_933 (release 4.0). This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase. . 
+PF08670 MEKHLA domain<br>The MEKHLA domain shares similarity with the PAS domain and is found in the 3' end of plant HD-ZIP III homeobox genes, and bacterial proteins.. 
+PF08671 Anti-repressor SinI<br>SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex.  When complexed with SinI, the SinR tetramer is disrupted such that is no longer able to bind DNA.. 
+PF08672 Anaphase promoting complex (APC) subunit 2<br>The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases.  Ubiquitin ligases catalyse the transfer of ubiquitin from the ubiquitin conjugating enzyme (E2), to the substrate protein.. 
+PF08673 Phosphoserine phosphatase RsbU, N-terminal domain<br>RsbU is a phosphoserine phosphatase which acts as a positive regulator of the general stress-response factor of gram positive organisms, sigma-B.  The phosphatase activity of RsbU is stimulated by association with the RsbT kinase.  Deletions in the N terminal domain are deleterious to the activity of RsbU  .. 
+PF08674 Acetylcholinesterase tetramerisation domain<br>The acetylcholinesterase tetramerisation domain is found at the C terminus and forms a left handed superhelix.. 
+PF08675 RNA binding domain<br>This domain corresponds to the RNA binding domain of Poly(A)-specific ribonuclease (PARN).. 
+PF08676 MutL C terminal dimerisation domain<br>MutL and MutS are key components of the DNA repair machinery that corrects replication errors  .  MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation  .. 
+PF08677 GP11 baseplate wedge protein<br>GP11 is a viral structural protein that connects short tail fibres to the baseplate.  The tail region is responsible for attachment to the host bacteria during infection.. 
+PF08678 Rsbr N terminal<br>Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B).\.     The structure of the N terminal domain belongs to the globin fold superfamily  .. 
+PF08679 Dissimilatory sulfite reductase D (DsrD)<br>The structure of the DsrD protein has shown it to contain a winged-helix motif similar to those found in DNA binding proteins  .  The structure suggests a possible role for DsrD in transcription of translation of genes which catalyse dissimilatory sulfite reduction.. 
+PF08680 Protein of unknown function (DUF1779)<br>This is a family of uncharacterised proteins.  The structure of the ywmB protein from Bacillus subtilis has shown it to adopt an alpha/beta fold.. 
+PF08681 Protein of unknown function (DUF1778)<br>This is a family of uncharacterised proteins.  The structure of one of the hypothetical proteins in this family has been solved and it forms a helix structure which may form interactions with DNA.. 
+PF08682 Protein of unknown function (DUF1780)<br>This is a family of uncharacterised proteins.  The structure of a hypothetical protein from Pseudomonas aeruginosa has shown it to adopt an alpha/beta fold.. 
+PF08683 DUF1781; CKK;<br>Microtubule-binding calmodulin-regulated spectrin-associated. This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.. 
+PF08684 DNA mimic ocr<br>The structure of an ocr protein from bacteriophage T7 has shown that this protein mimics the size and shape of a bent DNA molecule  . ocr has also been shown to be an inhibitor of the complex type I DNA restriction enzymes  .. 
+PF08685 GON domain<br>Mistry J, Rawlings ND. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins.  It contains several conserved cysteine residues.. 
+PF08686 PLAC (protease and lacunin) domain<br>Mistry J, Rawlings ND. The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins.  It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin  .. 
+PF08687 Apx/Shroom domain ASD2<br>Mistry J, Hildebrand JD. This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.. 
+PF08688 Apx/Shroom domain ASD1<br>Mistry J, Hildebrand JD. This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.  ASD1 has been implicated directly in F-actin binding.. 
+PF08689 Mediator complex subunit Med5<br>The mediator complex is required for the expression of nearly all RNA pol II dependent genes in Saccharomyces cerevisiae.  Deletion of the MED5 gene leads to increased transcription of nuclear genes encoding components of the oxidative phosphorylation machinery, and decreased transcription of mitochondrial genes encoding components of the same machinery  . There is no orthologue from pombe, and this subunit appears to be fungal specific  .. 
+PF08690 GET complex subunit GET2<br>This family corresponds to the GET complex subunit GET2.  The GET complex is involved in the retrieval of ER resident proteins from the Golgi  .. 
+PF08691 DNA repair proteins Nse5 and Nse6<br>Nse5 and Nse6 are non essential nuclear proteins that are critical for chromosome segregation in fission yeast  .  Nse5 forms a dimer with Nse6 and facilitates DNA repair as part of the Smc5-Smc6 holocomplex.. 
+PF08692 Mitochondrial protein Pet20<br>Pet20 is a mitochondrial protein which is thought to play a role in the correct assembly/maintenance of mitochondrial components  .. 
+PF08693 Transmembrane alpha-helix domain<br>SKG6/Axl2 are membrane proteins that show polarised intracellular localisation  . SKG6_Tmem is the highly conserved transmembrane alpha-helical domain of SKG6 and Axl2 proteins  ,  . The full-length fungal protein has a negative regulatory function in cytokinesis  .. 
+PF08694 DUF1782; <br>Ubiquitin-fold modifier-conjugating enzyme 1. Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1 is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family represents the E2-like enzyme.. 
+PF08695 DUF1783;<br>Cytochrome oxidase complex assembly protein 1. Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence  . The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex  .. 
+PF08696 DNA replication factor Dna2<br>Pfam-B_8878 (release 19.0). Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, ( 5'-flap endonuclease) and helicase activities.  It is required for Okazaki fragment processing and is involved in DNA repair pathways  .. 
+PF08698 DUF1784; <br>Fcf2 pre-rRNA processing. Pfam-B_13623 (release 19.0). This is a family of eukaryotic nucleolar proteins that are involved in pre-rRNA processing  .. 
+PF08699 Domain of unknown function (DUF1785)<br>Pfam-B_1585 (release 19.0). This region is found in argonaute   proteins and often co-occurs with Pfam:PF02179 and Pfam:PF02171.. 
+PF08700 Vps51/Vps67<br>This family includes a presumed domain found in a number of components of vesicular transport.  The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi .  Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1  .  Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues  .. 
+PF08701 GNL3L/Grn1 putative GTPase<br>Pfam-B_22650 (release 19.0). Grn1 (yeast) and GNL3L (human) are putative GTPases which are required for growth and play a role in processing of nucleolar pre-rRNA  .  This family contains a potential nuclear localisation signal.. 
+PF08702 Fibrinogen alpha/beta chain family<br>Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood.  This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).. 
+PF08703 PLC-beta C terminal<br>This domain corresponds to the alpha helical C terminal domain of phospholipase C beta.. 
+PF08704 tRNA methyltransferase complex GCD14 subunit<br>Pfam-B_5615 (release 19.0). GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA  .. 
+PF08705 Gag protein p6<br>HIV protein p6 contains two late-budding domains (L domains) which are short sequence motifs essential for viral particle release.  p6 interacts with the endosomal sorting complex and represents a docking site for several cellular and binding factors  .  The PTAP motif interacts with the cellular budding factor TSG101  .  This domain is also found in some chimpanzee immunodeficiency virus (SIV-cpz) proteins.. 
+PF08706 D5 N terminal like<br>This domain is found in D5 proteins of DNA viruses and bacteriophage P4 DNA primases phages.. 
+PF08707 Primase C terminal 2 (PriCT-2)   <br>This alpha helical domain is found at the C terminal of primases.. 
+PF08708 Primase C terminal 1 (PriCT-1)<br>This alpha helical domain is found at the C terminal of primases.. 
+PF08709 Inositol 1,4,5-trisphosphate/ryanodine receptor<br>This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor.  Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity  .. 
+PF08710 nsp9 replicase<br>nsp9 is a single-stranded RNA-binding viral protein likely to be involved in RNA synthesis  .  Its structure comprises of a single beta barrel  .. 
+PF08711 TFIIS;<br>TFIIS helical bundle-like domain. pdb_1wjt & Pfam-B_7936 (release 8.0). Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function  . Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex  . This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5 [5,6].. 
+PF08712 Scaffold protein Nfu/NifU N terminal<br>This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein.  Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters   .. 
+PF08713 DNA alkylation repair enzyme<br>Proteins in this family are predicted to be DNA alkylation repair enzymes.  The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.. 
+PF08714 Formaldehyde-activating enzyme (Fae)<br>Formaldehyde-activating enzyme is an enzyme required for energy metabolism and formaldehyde detoxification.  It catalyses the condensation of formaldehyde and tetrahydromethanopterin to methylene tetrahydromethanopterin  .. 
+PF08715 Papain like viral protease<br>This family of viral proteases are similar to the papain protease and are required for proteolytic processing of the replicase polyprotein.  The structure of this protein has shown it adopts a fold similar that of de-ubiquitinating enzymes  .. 
+PF08716 nsp7 replicase<br>nsp7 (non structural protein 7) has been implicated in viral RNA replication and is predominantly alpha helical in structure  . It forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure  .  The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase  .. 
+PF08717 nsp8 replicase<br>Viral nsp8 (non structural protein 8) forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure  .  The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase  .. 
+PF08718 Glycolipid transfer protein (GLTP)<br>GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids   .. 
+PF08719 Domain of unknown function (DUF1768)<br>This is a domain of unknown function.  It is alpha helical in structure. The GO annotation for this protein suggests it is involved in nematode larval development and has a positive regulation on growth rate.. 
+PF08720 FluC_stalk; <br>Influenza C hemagglutinin stalk. This domain corresponds to the stalk segment of hemagglutinin in influenza C virus.  It forms a coiled coil structure  .. 
+PF08721 TnsA_C;<br>TnsA endonuclease C terminal. The Tn7 transposase is composed of proteins TnsA and TnsB.  DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The C terminal domain of TnsA binds DNA.. 
+PF08722 TnsA_N;<br>TnsA endonuclease N terminal. The Tn7 transposase is composed of proteins TnsA and TnsB.  DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.. 
+PF08723 Gag protein p15<br>Gag p15 is a viral membrane-binding matrix protein which is alpha helical in structure.. 
+PF08724 Rep protein catalytic domain like<br>Adeno-associated virus (AAV) Replication (Rep) protein is essential for viral replication and integration.  The catalytic domain has DNA binding and endonuclease activity.. 
+PF08725 Integrin beta cytoplasmic domain<br>Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion.  Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit.  Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity.  This domain corresponds to the cytoplasmic domain of the beta subunit.. 
+PF08726 efhand_Ca_insen;<br>Ca2+ insensitive EF hand. EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes.  EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets.  This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties.  The calcium insensitive EF hand is still able to mediate protein-protein recognition  .. 
+PF08727 Poliovirus 3A protein like<br>This domain is found in positive-strand RNA viruses.  The 3A protein is a critical component of the poliovirus replication complex, and is also an inhibitor of host cell ER to Golgi transport.. 
+PF08728 CRT10<br>CRT10 is a transcriptional regulator of ribonucleotide reductase (RNR) genes  .  RNR catalyses the rate limiting step in dNTP synthesis.  Mutations in CRT10 have been shown to enhance hydroxyurea resistance  .. 
+PF08729 HPC2; HRD;<br>HPC2 and ubinuclein domain. Mistry J, Wood V, Balaji S, Iyer LM, Aravind L. HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription  .  It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes  . Hpc2 is one of the proteins  of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone  proteins. the Hip4 sequence from SCH. pombe is an integral component  of this complex that is required for transcriptional silencing at  multiple loci  . HPC2, ubinuclein/yemanuclein, and the cell cycle  regulator FLJ25778 share a conserved domain that is predicted to  bind histone tails  . This domain is also referred to as the  HRD or Hpc2-related domain.. 
+PF08730 Rad33<br>Rad33 is involved in nucleotide excision repair (NER).  NER is the main pathway for repairing DNA lesions induced by UV. Cells deleted for RAD33 display intermediate UV sensitivity that is epistatic with NER  .. 
+PF08731 Transcription factor AFT<br>AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis .  This family includes the paralogous pair of transcription factors AFT1 and AFT2.. 
+PF08732 HIM1<br>HIM1 (high induction of mutagenesis protein 1) plays a role in the control of spontaneous and induced mutagenesis  .  It is thought to participate in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage.. 
+PF08733 PalH/RIM21<br>PalH (also known as RIM21) is a transmembrane protein required for proteolytic cleavage of Rim101/PacC transcription factors which are activated by C terminal proteolytic processing. Rim101/PacC family proteins play a key role in pH-dependent responses and PalH has been implicated as a pH sensor  .. 
+PF08734 GYD domain<br>This protein is found in a range of bacteria.  It is usually less than 100 amino acids in length. The function of the protein is unknown.  It may belong to the dimeric alpha/beta barrel superfamily.. 
+PF08735 Putative pyruvate format-lyase activating enzyme (DUF1786)<br>This family is annotated as pyruvate formate-lyase activating enzyme (EC:1.97.1.4) in UniProt. It is not clear where this annotation comes from.. 
+PF08736 FERM adjacent (FA)<br>This region is found adjacent to Band 4.1 / FERM domains (Pfam:PF00373) in a subset of FERM containing protein.  The region has been hypothesised to play a role in regulatory adaptation, based on similarity to other protein kinase substrates .. 
+PF08737 Rgp1<br>Rgp1 forms heterodimer with Ric1 (Pfam:PF07064) which associates with Golgi membranes and functions as a guanyl-nucleotide exchange factor  .. 
+PF08738 Gon7 family<br>In S. cerevisiae Gon7 is a member of the KEOPS protein complex. A protein complex proposed to be involved in transcription and promoting telomere uncapping and telomere elongation  .. 
+PF08740 BCS1 N terminal<br>Pfam-B_10126 (release 19.0). This domain is found at the N terminal of the mitochondrial ATPase BSC1.  It encodes the import and intramitochondrial sorting for the protein  .. 
+PF08741 YwhD family<br>PSI2 target PSI-blast from BH3813. This family of proteins are currently uncharacterised.  They are around 170 amino acids in length.. 
+PF08742 DUF1787; <br>This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.  It is often found on proteins containing Pfam:PF00094 and Pfam:PF01826.. 
+PF08743 SUMO_ligase; Nse4;<br>Nse4 is a component of the Smc5/6 DNA repair complex.  It forms interactions with Smc5 and Nse1  . The exact function of this highly conserved C-terminal domain is not known.. 
+PF08744 Plant transcription factor NOZZLE<br>Pfam-B_86265 (release 19.0). NOZZLE is a transcription factor that plays a role in patterning the proximal-distal and adaxial-abaxial axes   .. 
+PF08745 UPF0278 family<br>Members of this family are uncharacterised proteins about 200 amino acids in length.. 
+PF08746 RING-like domain<br>This is a zinc finger domain that is related to the C3HC4 RING finger domain (Pfam:PF00097).. 
+PF08747 Domain of unknown function (DUF1788)<br>PSI2 target Npun02004481. Putative uncharacterised domain in proteins of length around 200 amino acids.. 
+PF08748 Domain of unknown function (DUF1789)<br>PSI2 target CAE43632.1. Putative uncharacterised domain found in phage-related conserved hypothetical protein from Bordetella.. 
+PF08750 CNP1-like family<br>PSI2 target CAB84161.1. This family of proteins are likely to be lipoproteins. CNP1 (cryptic neisserial protein) has been expressed in E. coli and shown to be localised periplasmicly  .. 
+PF08751 TrwC relaxase<br>Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer.  TrwC binds to the origin of transfer (oriT) and melts the double helix.. 
+PF08752 Gamma-COP;<br>Coatomer gamma subunit appendage platform subdomain. COPI-coated vesicles function in retrograde transport from the Golgi to the ER, and in intra-Golgi transport.  This is the platform subdomain of the coatomer gamma subunit appendage domain.\.       It carries a protein-protein interaction site at UniProt:P53620, residue W776, which in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2  .. 
+PF08753 NikR C terminal nickel binding domain<br>NikR is a transcription factor that regulates nickel uptake. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel.  This domain corresponds to the C terminal regulatory domain which contains four nickel binding sites at the tetramer interface  .. 
+PF08755 Hemimethylated DNA-binding protein YccV like<br>YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression  .  The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.. 
+PF08756 YfkB-like domain<br>PSI2 structural target yfkB. This protein is adjacent to YfkA in B. subtilis.  In other bacterial species it is fused to this protein. As YfkA contains a Radical SAM domain it suggests this domain is interacts with them.. 
+PF08757 CotH protein<br>PSI2 structural target cotH. Members of this family include the spore coat protein H (cotH).. 
+PF08758 Cadherin prodomain like<br>Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion.  They are activated through cleavage of a prosequence in the late Golgi.  This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions  .. 
+PF08759 Domain of unknown function (DUF1792)<br>PSI2 structural target AAO75156.1. This putative domain is probably missannotated as a glycosyl transferase 8 family member. This domain is found at the C-terminus of protein such as Swiss:Q97P75 that also contain the glycosyl transferase domain at the N-terminus.. 
+PF08760 Domain of unknown function (DUF1793)<br>PSI2 structural target AAO78587.1. This presumed domain is found at the C-terminus of a glutaminase protein from fungi  . This domain is also found as a single domain protein in Bacteroides thetaiotaomicron.. 
+PF08761 dUTPase<br>2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23).  Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms  .  This family contains both dUTPase homologues of dUTPase including dCTPase of phage T4.. 
+PF08762 CRPV capsid protein like<br>This is a family of capsid proteins found in positive stranded ssRNA viruses such as cricket paralysis virus (CRPV).  It forms an all beta sheet structure  .. 
+PF08763 Voltage gated calcium channel IQ domain<br>Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential.  The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin  .  The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).. 
+PF08764 Staphylococcus aureus coagulase<br>Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages.  The resulting complex directly initiates blood clotting.. 
+PF08765 Mor transcription activator family<br>Mor (Middle operon regulator) is a sequence specific DNA binding protein.  It mediates transcription activation through its interactions with the C-terminal domains of the alpha and sigma subunits of bacterial RNA polymerase.  The N terminal region of Mor is the dimerisation region, and the C terminal contains a helix-turn-helix motif which binds DNA.. 
+PF08766 DEK C terminal domain<br>DEK is a chromatin associated protein that is linked with cancers and autoimmune disease.  This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients  .\.     The structure of this domain shows it to be homologous to the E2F/DP transcription factor family  .  This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphastases such as Swiss:Q6NN85.. 
+PF08767 CRM1 C terminal<br>CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran.  This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat  .. 
+PF08768 Domain of unknown function (DUF1794)<br>Mistry J, Pollington JE. This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.. 
+PF08769 Sporulation initiation factor Spo0A C terminal<br>The response regulator Spo0A is comprised of a phophoacceptor domain and a transcription activation domain.  This domain corresponds to the transcription activation domain and forms an alpha helical structure comprising of 6 alpha helices.  The structure contains a helix-turn-helix and binds DNA   .. 
+PF08770 Sulphur oxidation protein SoxZ<br>SoxZ forms an anti parallel beta structure and forms a complex with SoxY.  Sulphur oxidation occurs at the thiol of a conserved cysteine residue of the SoxY subunit  .. 
+PF08771 Rapamycin binding domain<br>This domain forms an alpha helical structure and binds to rapamycin  .. 
+PF08772 Nin one binding (NOB1) Zn-ribbon like<br>This domain corresponds to a zinc ribbon and is found on the RNA binding protein NOB1 (Nin one binding).. 
+PF08773 Cathepsin C exclusion domain<br>Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases.  This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini.  It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands  . Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor  .. 
+PF08774 VRR-NUC domain<br>
+PF08775 ParB family<br>ParB is a component of the par system which mediates accurate DNA partition during cell division.  It recognises A-box and B-box DNA motifs.  ParB forms an asymmetric dimer with 2 extended helix-turn-helix (HTH) motifs that bind to A-boxes.  The HTH motifs emanate from a beta sheet coiled coil DNA binding module  . Both DNA binding elements are free to rotate around a flexible linker, this enables them to bind to complex arrays of A- and B-box elements on adjacent DNA arms of the looped partition site  .. 
+PF08776 VASP tetramerisation domain<br>Vasodilator-stimulated phosphoprotein (VASP) is an actin cytoskeletal regulatory protein.  This region corresponds to the tetramerisation domain which forms a right handed alpha helical coiled coil structure  .. 
+PF08777 RNA binding motif<br>This domain is found in protein La which functions as an RNA chaperone during RNA polymerase III transcription, and can also stimulate translation initiation. It contains a five stranded beta sheet which forms an atypical RNA recognition motif  .. 
+PF08778 HIF-1 alpha C terminal transactivation domain<br>Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1.  It plays a key role in cellular response to low oxygen tension. This region corresponds to the C terminal transactivation domain.. 
+PF08779 SARS coronavirus X4 like<br>The structure of the coronavirus X4 protein (also known as 7a and U122) shows similarities to the immunoglobulin like fold and suggests a binding activity to integrin I domains  .  In SARS-CoV- infected cells, the X4 protein is expressed and retained intra-cellularly within the Golgi network  .  X4 has been implicated to function during the replication cycle of SARS-CoV  .. 
+PF08780 Nucleotidyltransferase substrate binding protein like<br>Nucleotidyltransferases (EC 2.7.7) comprise a large enzyme family with diverse roles in polynucleotide synthesis and modification. This domain is structurally related to kanamycin nucleotidyltransferase (KNTase) and forms a complex with HI0073, a sequence homolog of the nucleotide-binding domain of this nucleotidyltransferase superfamily  .. 
+PF08781 Transcription factor DP<br>DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression.  The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer   and negatively regulates the G1-S transition.. 
+PF08782 c-SKI Smad4 binding domain<br>c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins  .  This domain binds to Smad4  . 
+PF08783 DWNN domain<br>DWNN is a ubiquitin like domain found at the N terminus of the RBBP6 family of splicing-associated proteins  .  The DWNN domain is independently expressed in higher vertebrates so it may function as a novel ubiquitin-like modifier of other proteins  .. 
+PF08784 Replication protein A C terminal<br>This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A).  RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.. 
+PF08785 Ku C terminal domain like<br>The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired.  Ku is a component of a multi-protein complex that is involved in the NHEJ.  Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).  This domain is found at the C terminal of Ku which binds to DNA-PKcs  .. 
+PF08786 Domain of unknown function (DUF1795)<br>This is a bacterial domain of unknown function.  It forms an antiparallel beta sheet structure and contains some alpha helical regions.. 
+PF08787 Alginate lyase<br>Alginate lyases are enzymes that degrade the linear polysaccharide alignate.\. They cleave the glycosidic linkage of alignate through a beta-elimination reaction.  This family forms an all beta fold and is different to all alpha fold of Pfam:PF05426.. 
+PF08788 NHR2 domain like<br>The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerisation and protein-protein interactions.  It forms an alpha-helical tetramer  .. 
+PF08789 PBCV-specific basic adaptor domain<br>The small PBCV-specific basic adaptor domain is found fused to S/T protein kinases and the 2-Cysteine domain  .. 
+PF08790 LYAR-type C2HC zinc finger <br>This C2HC zinc finger is found in LYAR proteins such as Swiss:Q08288 which are involved in cell growth regulation.. 
+PF08792 A2L zinc ribbon domain<br>This zinc ribbon domain is found associated with some viral A2L transcription factors  .. 
+PF08793 2-cysteine adaptor domain<br>The virus-specific 2-cysteine adaptor domain is found fused to OTU/A20-like peptidases and S/T protein kinases.  The domain associations of these proteins indicate that they might function as viral adaptors connecting the kinases and OTU/A20 peptidases to specific targets  .. 
+PF08794 Lipoprotein GNA1870 C terminal like<br>GNA1870 is a surface exposed lipoprotein in Neisseria meningitidis that and is a potent antigen of Meningococcus.  The structure of the C terminal domain consists of an anti-parallel beta barrel overlaid by a short alpha helical region  .. 
+PF08795 Putative papain-like cysteine peptidase (DUF1796)<br>
+PF08796 Protein of unknown function (DUF1797)<br>This is a domain of unknown function.  It forms a central anti-parallel beta sheet with flanking alpha helical regions.. 
+PF08797 HIRAN domain<br>The HIRAN domain (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. The HIRAN domain is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes  . It has been predicted that this domain functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks  . 
+PF08798 CRISPR associated protein<br>This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.. 
+PF08799 pre-mRNA processing factor 4 (PRP4) like<br>This small domain is found on PRP4 ribonuleoproteins.  PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.. 
+PF08800 VirE N-terminal domain<br>PSI2 target AAO76744.1. This presumed domain is found at the N-terminus of VirE proteins.. 
+PF08801 Nup133_N;<br>Nup133 N terminal like. Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure  . This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.. 
+PF08802 Cytochrome B6-F complex Fe-S subunit <br>The cytochrome B6-F complex mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  This domain corresponds to the alpha helical transmembrane domain of the cytochrome B6-F complex iron-sulphur subunit.. 
+PF08803 Putative mono-oxygenase ydhR<br>ydhR is a homodimeric protein that comprises of a central four-stranded beta sheet and four surrounding alpha helices  .  It shows structural homology to the ActVA-Orf6 and YgiN proteins which indicates it could be a mono-oxygenase.. 
+PF08804 gp32 DNA binding protein like<br>gp32 is a single stranded (ss) DNA binding protein in bacteriophage T4 that is essential for DNA replication, recombination and repair. The ssDNA binding cleft of gp32 comprises regions from three structural subdomains  .. 
+PF08805 PilS N terminal<br>Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells.  In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator  .  Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus  .. 
+PF08806 Sep15/SelM redox domain<br>Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif  .  This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum  .. 
+PF08807 Bacterial domain of unknown function (DUF1798)<br>This domain is found in many hypothetical proteins.  The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.. 
+PF08808 RES domain<br>PSI2 target CAE41587.1. This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.. 
+PF08809 Phage related hypothetical protein (DUF1799)<br>PSI2 target CAE43631.1. Members of this family are about 100 amino acids in length and are uncharacterised.. 
+PF08810 Kinase associated protein B<br>This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.. 
+PF08811 Protein of unknown function (DUF1800)<br>PSI2 target AAK23953.1. This is a family of large bacterial proteins of unknown function.. 
+PF08812 YtxC-like family<br>PSI2 target YtxC B.subtilis. This family includes proteins similar to B. subtilis YtxC an uncharacterised protein.. 
+PF08813 Phage tail protein<br>PSI2 target CAE43633.1. This family of proteins include phage tail proteins.  They probably include bacterial Ig-like domains related to Pfam:PF02368. Which also includes a number of phage tail invasin proteins.. 
+PF08814 XisH protein<br>PSI2 target ZP_00111899.1. The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required  .. 
+PF08815 Nuclear receptor coactivator<br>This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.. 
+PF08816 Inhibitor of vertebrate lysozyme (Ivy)<br>This bacterial family is a strong inhibitor of vertebrate lysozyme.. 
+PF08817 WXG100 protein secretion system (Wss), protein YukD<br>Mistry J, Desvaux M, Burroughs AM, Iyer LM, Aravind L. The YukD protein family members participate in the formation of a translocon required for the secretion of WXG100 proteins (Pfam:PF06013) in monoderm bacteria, with the WXG100 protein secretion system (Wss). Like the cytoplasmic protein EsaC in Staphylococcus aureus, YukD was hypothesized to play a role of a chaperone. YukD adopts a ubiquitin-like fold  . Usually, ubiquitin covalently binds to protein and flags them for protein degradation, however conjugation assays have indicated that the classical YukD lacks the capacity for covalent bond formation with other proteins  . In contrast to the situation in firmicutes, YukD-like proteins in actinobacteria are often fused to a transporter involved in the ESAT-6/ESX/Wss secretion pathway [6,7]. Members of the YukD family are also associated in gene neighborhoods with other enzymatic members of the ubiquitin signaling and degradation pathway such as the E1, E2 and E3 trienzyme complex that catalyze ubiquitin transfer to substrates, and the JAB family metallopeptidases that are involved in its release  . This suggests that a subset of the YukD family in bacteria are conjugated and released from proteins as in the eukaryotic ubiquitin-mediated signaling and degradation pathway  .. 
+PF08818 Domain of unknown function (DU1801)<br>PSI2 target AAO81511.1. This large family of bacterial proteins is uncharacterised.  They contain a presumed domain about 110 amino acids in length.. 
+PF08819 Domain of unknown function (DUF1802)<br>The function of this family is unknown.  This region is found associated with a Pfam:PF04471 suggesting they could be part of a restriction modification system... 
+PF08820 Domain of unknown function (DUF1803)<br>PSI2 target AAO81393.1. This small domain is found in one or two copies in proteins from bacteria. The function of this domain is unknown.. 
+PF08821 CGGC domain<br>PSI2 target AAB98576.1. This putative domain contains a quite highly conserved sequence of CGGC in its central region.  The domain has many conserved cysteines and histidines suggestive of a zinc binding function.. 
+PF08822 Protein of unknown function (DUF1804)<br>PSI2 target CAB84459.1. This family of bacterial protein is uncharacterised.. 
+PF08823 Putative peptidoglycan binding domain<br>This family may be a peptidoglycan binding domain.. 
+PF08824 Serine rich protein interaction domain<br>This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate).  This domain folds into a four helix bundle which is associated with protein-protein interactions  .. 
+PF08825 E2 binding domain<br>E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades.  This is an E2 binding domain that is found on NEDD8 activating E1 enzyme.  The domain resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains  .. 
+PF08826 DMPK coiled coil domain like<br>This domain is found in the myotonic dystrophy protein kinase (DMPK) and adopts a coiled coil structure.  It plays a role in dimerisation  .. 
+PF08827 Domain of unknown function (DUF1805)<br>This domain is found in bacteria and archaea and has an N terminal tetramerisation region that is composed of beta sheets.. 
+PF08828 Doublesex dimerisation domain<br>Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila.\.     The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor  .. 
+PF08829 Alpha C protein N terminal<br>The alpha C protein (ACP) is found in Streptococcus and acts as an invasin which plays a role in the internalisation and translocation of the organism across human epithelial surfaces. Group B Streptococcus is the leading cause of diseases including bacterial pneumonia, sepsis and meningitis.\.  The N terminal of ACP is associated with virulence and forms a beta sandwich and a three helix bundle [1-3].. 
+PF08830 Protein of unknown function (DUF1806)<br>This is a bacterial family of uncharacterised proteins.  The structure of one of the proteins in this family has been solved and it adopts a beta barrel-like structure.. 
+PF08831 Class II MHC-associated invariant chain trimerisation domain<br>The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers.  This domain is involved in trimerisation of the ectoderm and interferes with DM/class II binding.  The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules  .. 
+PF08832 Steroid receptor coactivator<br>This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding  .  The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.. 
+PF08833 Axin beta-catenin binding domain<br>This domain is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex.  It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin  .. 
+PF08837 Protein of unknown function (DUF1810)<br>This is a family of uncharacterised proteins.  The structure of one of the members in this family has been solved and it adopts a mainly alpha helical structure.. 
+PF08838 Protein of unknown function (DUF1811)<br>This is a bacterial family of uncharacterised proteins.  Some of the proteins are annotated as being transcriptional regulators (see Swiss:Q4MQL7, Swiss:Q65MA2).  The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.. 
+PF08839 DNA replication factor CDT1 like<br>CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin.  Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin.  This region of CDT1 binds to Geminin  .. 
+PF08840 BAAT / Acyl-CoA thioester hydrolase C terminal<br>Pfam-B_4571 (release 20.0). This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).. 
+PF08841 Diol dehydratase reactivase ATPase-like domain<br>Diol dehydratase (DDH, EC:4.2.1.28) and its isofunctional homologue glycerol dehydratase (GDH, EC.4.2.1.30) are enzymes which catalyse the conversion of glycerol 1,2-propanediol, and 1,2-ethanediol to aldehydes  .  These reactions require coenzyme B12.  Cleavage of the Co-C bond of coenzyme B12 by substrates or coenzyme analogues results in inactivation during which coenzyme B12 remains tightly bound to the apoenzyme.  This family comprises of the large subunit of the diol dehydratase and glycerol dehydratase reactivating factors whose function is to reactivate the holoenzyme by exchange of a damaged cofactor for intact coenzyme.. 
+PF08842 DUF1812; Mfa;<br>Fimbrillin-A associated anchor proteins Mfa1 and Mfa2. PSI2 target AAO79331.1. This family of proteins may be lipoproteins principally from bacilli.  They are between 300 and 400 residues. Many Bacteroides-like bacterial species, including Porphyromonas gingivalis, the causal agent of periodontal infection, carry at least two types of fimbriae, namely FimA and Mfa1 fimbriae, following the names of their major subunit proteins  . Normally, FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells; however, in the absence of Mfa2 protein, the Mfa1 fimbriae are also very long and are not attached. Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells to the extent that Mfa2 is located on the cell surface and probably associated with Mfa1 fimbriae in such a way that it anchors the Mfa1 fimbriae to the cell surface and regulates Mfa1 filament length  .. 
+PF08843 Nucleotidyl transferase of unknown function (DUF1814)<br>PSI2 target CAD86002.1. This large family of proteins are largely uncharacterised.  Some are annotated as abortive infective proteins but support for this annotation could not be found. This family was recently identified as belonging to the nucleotidyltransferase superfamily  .. 
+PF08844 Domain of unknown function (DUF1815)<br>PSI2 target ZP_00111304.2 (BIG_33). This presumed domain is about 100 amino acids in length and is functionally uncharacterised.. 
+PF08845 DUF1813;<br>Toxin SymE, type I toxin-antitoxin system. PSI2 target AAC77303.1. SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin [1,2].. 
+PF08846 Domain of unknown function (DUF1816)<br>PSI2 target ZP_00109395.2 BIG_34. Swiss:Q4C9H3 is associated with the Pfam:PF01383 domain suggesting this presumed domain could have a role in phycobilisomes.. 
+PF08847 Domain of unknown function (DUF1817)<br>PSI2 target ZP_00111140.1 BIG_36. Members of this family are functionally uncharacterised.. 
+PF08848 Domain of unknown function (DUF1818)<br>PSI2 target ZP_00110314.1 BIG_37. This presumed domain is found in a small family of cyanobacterial protein. These proteins are functionally uncharacterised.. 
+PF08849 Putative inner membrane protein (DUF1819)<br>PSI2 target ZP_00108899.1 BIG_41. These proteins are functionally uncharacterised.  Several are annotated as putative inner membrane proteins.. 
+PF08850 Domain of unknown function (DUF1820)<br>PSI2 target AAG07366.1 BIG_46. This family includes small functionally uncharacterised proteins around 100 amino acids in length.. 
+PF08852 Protein of unknown function (DUF1822)<br>PSI2 target ZP_00109005.1 BIG_39. This family of proteins are functionally uncharacterised.. 
+PF08853 Domain of unknown function (DUF1823)<br>PSI2 target ZP_00108651.1 BIG_42. This presumed domain is functionally uncharacterised.. 
+PF08854 Domain of unknown function (DUF1824)<br>This uncharacterised family of proteins are principally found in cyanobacteria.. 
+PF08855 Domain of unknown function (DUF1825)<br>This uncharacterised family of proteins are principally found in cyanobacteria.. 
+PF08856 Protein of unknown function (DUF1826)<br>These proteins are functionally uncharacterised.. 
+PF08857 Putative ParB-like nuclease<br>PSI2 target AAG07772.1 BIG_47. This domain is probably distantly related to Pfam:PF02195. Suggesting these uncharacterised proteins have a nuclease function.. 
+PF08858 IDEAL domain<br>This short domain is found at the C-terminus of proteins in the UPF0302 family.  The domain is named after the sequence of the most conserved region in some members.\.  The function of this domain is unknown.. 
+PF08859 DGC domain<br>This domain appears to be a zinc binding domain from the conservation of four potential chelating cysteines. The domain is named after a conserved central motif. The function of this domain is unknown.. 
+PF08860 Domain of unknown function (DUF1827)<br>This presumed domain has no known function.. 
+PF08861 Domain of unknown function DUF1828<br>This presumed domain is functionally uncharacterised.. 
+PF08862 Domain of unknown function DUF1829<br>This short domain is usually associated with Pfam:PF08861.. 
+PF08863 YolD-like protein<br>Members of this family are functionally uncharacterised. However it has been predicted that thes proteins are functionally equivalent to the UmuD subunit of polymerase V from gram-negative bacteria  .. 
+PF08864 UPF0302 domain<br>This family is known as UPF0302. It is currently uncharacterised.. 
+PF08865 Domain of unknown function (DUF1830)<br>This family of short proteins is functionally uncharacterised.. 
+PF08866 Putative amino acid metabolism<br>Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.. 
+PF08867 FRG domain<br>This presumed domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised.. 
+PF08868 YugN-like family<br>This family of proteins related to B. subtilis YugN are functionally uncharacterised.. 
+PF08869 XisI protein<br>The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required  .. 
+PF08870 Domain of unknown function (DUF1832)<br>This family of proteins are functionally uncharacterised.. 
+PF08872 KGK domain<br>This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.. 
+PF08873 Domain of unknown function (DUF1834)<br>This family of proteins are functionally uncharacterised. One member is the Gp37 protein from the FluMu prophage.. 
+PF08874 Domain of unknown function (DUF1835)<br>This family of proteins are functionally uncharacterised.. 
+PF08875 Domain of unknown function (DUF1833)<br>This family of proteins are functionally uncharacterised and are  predicted to adopt an all-beta fold  . They are often found in gene neighborhoods containing genes for an NlpC peptidase and a  Ubiquitin domain predicted to be involved in tail assembly  . . 
+PF08876 Domain of unknown function (DUF1836)<br>This family of proteins are functionally uncharacterised.. 
+PF08877 MepB protein<br>MepB is a functionally uncharacterised protein in the mepRAB gene cluster of Staphylococcus aureus.. 
+PF08878 Domain of unknown function (DUF1837)<br>This family of proteins are functionally uncharacterised.. 
+PF08879 WRC<br>The WRC domain, named after the conserved Trp-Arg-Cys motif,  contains two distinctive features: a putative nuclear localisation  signal and a zinc-finger motif (C3H). It is suggested that  the WRC domain functions in DNA binding  .. 
+PF08880 QLQ<br>The QLQ domain is named after the conserved Gln, Leu, Gln motif.  The QLQ domain is found at the N-terminus of SWI2/SNF2 protein,  which has been shown to be involved in protein-protein interactions.   This domain has thus been postulated to be involved in mediating  protein interactions  .. 
+PF08881 CNVH; <br>CyanoVirin-N Homology domains are found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as filamentous ascomycetes and in the fern Ceratopteris richardii.. 
+PF08882 Acetone carboxylase gamma subunit<br>Acetone carboxylase is the key enzyme of bacterial acetone metabolism, catalysing the condensation of acetone and CO(2) to form acetoacetate.. 
+PF08883 Dopa 4,5-dioxygenase family<br>This family of proteins are related to Swiss:P87064 a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.. 
+PF08884 Flagellin D3 domain<br>This domain is found in the central portion bacterial flagellin FliC.  The domain contains a structural motif called a beta-folium fold  .  Although no specific function is assigned to this domain its deletion leads to a reduction in filament stability  .. 
+PF08885 GSCFA family<br>This family of proteins are functionally uncharacterised. They have been named GSCFA after a highly conserved N-terminal motif in the alignment. Distant similarity to the Pfam:PF00657 lipases suggests these proteins are likely to be enzymes.. 
+PF08886 Glutamate-cysteine ligase<br>This is a rare family of glutamate--cysteine ligases, EC:6.3.2.2, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria  . It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase.  The structure of this family has been solved, and is similar to that of human glutathione synthetase and very different to gamma-glutamylcysteine synthetase from Escherichia coli.. 
+PF08887 GAD-like domain<br>This domain is functionally uncharacterised, but it appears to be distantly related to the GAD domain Pfam:PF02938.. 
+PF08888 HopJ type III effector protein<br>Pathovars of Pseudomonas syringae interact with their plant hosts via the action of Hrp outer protein (Hop) effector proteins, injected into plant cells by the type III secretion system. The proteins in this family are called HopJ after the original member HopPmaJ  .. 
+PF08889 WbqC-like protein family<br>This family of proteins are functionally uncharacterised. However it is found in an O-antigen gene cluster in E. coli   and other bacteria   suggesting a role in O-antigen production. Feng et al. suggest that wbnG may code for a glycine transferase  .. 
+PF08890 Phage XkdN-like protein<br>This family of proteins are functionally uncharacterised. They are found in prophage sequence in various bacteria.. 
+PF08891 YfcL protein<br>This family of proteins are functionally uncharacterised. THey are related to the short YfcL protein from E. coli.. 
+PF08892 YqcI/YcgG family<br>This family of proteins are functionally uncharacterised. The family include YqcI and YcgG from B. subtilis. The alignment contains a conserved FPC motif at the N-terminus and CPF at the C-terminus.. 
+PF08893 Domain of unknown function (DUF1839)<br>This family of proteins are functionally uncharacterised.. 
+PF08894 Protein of unknown function (DUF1838)<br>This family of proteins are functionally uncharacterised.. 
+PF08895 Domain of unknown function (DUF1840)<br>This family of proteins are functionally uncharacterised.. 
+PF08896 Domain of unknown function (DUF1842)<br>This domain is found at the N-terminus of proteins that are functionally uncharacterised.. 
+PF08897 Domain of unknown function (DUF1841)<br>This family of proteins are functionally uncharacterised.. 
+PF08898 Domain of unknown function (DUF1843)<br>This domain is found at the C-terminus of a family of proteins that are functionally uncharacterised. The presumed domain is about 60 amino acid residues in length and is found independently in some proteins.. 
+PF08899 Domain of unknown function (DUF1844)<br>This family of proteins are functionally uncharacterised.. 
+PF08900 Domain of unknown function (DUF1845)<br>This family of proteins are functionally uncharacterised.. 
+PF08901 Protein of unknown function (DUF1847)<br>This family of proteins are functionally uncharacterised. THey contain 4 N-terminal cysteines that may form a zinc binding domain.. 
+PF08902 Domain of unknown function (DUF1848)<br>This family of proteins are functionally uncharacterised. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of Pfam:PF04055.. 
+PF08903 Domain of unknown function (DUF1846)<br>This family of proteins are functionally uncharacterised. Some members of the family are annotated as ATP-dependent peptidases. However, we can find no support for this annotation.. 
+PF08904 Domain of unknown function (DUF1849)<br>This family of proteins are functionally uncharacterised.. 
+PF08905 Domain of unknown function (DUF1850)<br>This family of proteins are functionally uncharacterised. Some members of this family appear to be misannotated as RocC an amino acid transporter from B. subtilis.. 
+PF08906 Domain of unknown function (DUF1851)<br>This domain is found at the C-terminus of a variety of proteins that are functionally uncharacterised.. 
+PF08907 Domain of unknown function (DUF1853)<br>This family of proteins are functionally uncharacterised.. 
+PF08908 Domain of unknown function (DUF1852)<br>This family of proteins are functionally uncharacterised.. 
+PF08909 Domain of unknown function (DUF1854)<br>This potential domain is functionally uncharacterised. It is found at the C-terminus of a number of ATP transporter proteins suggesting this domain may be involved in ligand binding.. 
+PF08910 DUF1855; Aida_N; Aida-C2;<br>Mistry J, Sammut SJ, Coggill P, Zhang D, Eberhardt R. This is the N-terminal domain of the axin interactor, dorsalization-associated protein family  .. 
+PF08911 NUP50 (Nucleoporin 50 kDa)<br>Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha  .. 
+PF08912 Rho Binding<br>Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions  .. 
+PF08913 Vinculin Binding Site<br>Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a secondary structure prediction of four amphipathic helices. The hydrophobic residues that define the VBS are themselves 'masked' and are buried in the core of a series of helical bundles that make up the talin rod  .. 
+PF08914 Rap1 Myb domain<br>
+PF08915 Archaea-specific editing domain of threonyl-tRNA synthetase<br>Archaea-specific editing domain of threonyl-tRNA synthetase, with marked structural similarity to D-amino acids deacylases found in eubacteria and eukaryotes. This domain can bind D-amino acids, and ensures high fidelity during translation. It is especially responsible for removing incorrectly attached serine from tRNA-Thr. The domain forms a fold that can be be defined as two layers of beta-sheets (a three-stranded sheet and a five-stranded sheet), with two alpha-helices located adjacent to the five-stranded sheet  .. 
+PF08916 Phenylalanine zipper<br>The phenylalanine zipper consists of aromatic side chains from ten phenylalanine residues that are stacked within a hydrophobic core. This zipper mediates dimerisation of various proteins, such as APS, SH2-B and Lnk  .. 
+PF08917 Transforming growth factor beta receptor 2 ectodomain<br>The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9)  .. 
+PF08918 PhoQ Sensor<br>The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane  .. 
+PF08919 F-actin binding<br>The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function  .. 
+PF08920 Splicing factor 3B subunit 1<br>This family consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C-terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly  .. 
+PF08921 Domain of unknown function (DUF1904)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08922 Domain of unknown function (DUF1905)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08923 Mitogen-activated protein kinase kinase 1 interacting<br>Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer  .. 
+PF08924 Domain of unknown function (DUF1906)<br>This domain is found in a set of uncharacterised hypothetical bacterial proteins.. 
+PF08925 Domain of Unknown Function (DUF1907)<br>The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase  .. 
+PF08926 Domain of unknown function (DUF1908)<br>This domain is found in a set of hypothetical/structural eukaryotic proteins.. 
+PF08928 Domain of unknown function (DUF1910)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08929 Domain of unknown function (DUF1911)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08930 Domain of unknown function (DUF1912)<br>This domain has no known function. It is found in various Streptococcal proteins.. 
+PF08931 Domain of unknown function (DUF1913)<br>This domain has no known function. It is found in a various putative receptor proteins from Lactococcus bacteriophages.. 
+PF08932 Domain of unknown function (DUF1914)<br>This domain has no known function. It is found in a various putative receptor proteins from Lactococcus bacteriophages.. 
+PF08933 Domain of unknown function (DUF1864)<br>This domain has no known function. It is found in various hypothetical and conserved domain proteins.. 
+PF08934 Rb C-terminal domain<br>The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure  .. 
+PF08935 DUF1865;<br>Viral protein VP4 subunit. This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice  . VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1  .. 
+PF08936 Carboxysome Shell Carbonic Anhydrase<br>Carboxysome Shell Carbonic Anhydrase is a bacterial carbonic anhydrase localised in the carboxysome, where it converts bicarbonate ions to carbon dioxide for use in carbon fixation. It contains three domains, these being: (1) an N-terminal domain composed primarily of four alpha-helices; (2) a catalytic domain containing a tightly bound zinc ion and (3) a C-terminal domain with weak structural similarity to the catalytic domain  .. 
+PF08937 MTH538 TIR-like domain (DUF1863)<br>This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein  . This domain is similar to  the TIR domain.. 
+PF08938 DUF1916;<br>Mistry J, Sammut SJ, Eberhardt R. This domain is found at the N-terminus of HBS1 proteins. It interacts with the ribosomal protein rpS3 at the mRNA entry site  .. 
+PF08939 Domain of unknown function (DUF1917)<br>This domain is found in various hypothetical and basophilic leukaemia proteins. It has no known function.. 
+PF08940 Domain of unknown function (DUF1918)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF08941 USP8 interacting<br>This domain interacts with the UBP deubiquitinating enzyme USP8.. 
+PF08942 Domain of unknown function (DUF1919)<br>This domain has no known function. It is found in various hypothetical and putative bacterial proteins.. 
+PF08943 CsiD<br>This family consists of various bacterial proteins pertaining to the non-haem Fe(II)-dependent oxygenase family. Exact function is unknown, but a putative role includes involvement in the control of utilisation of gamma-aminobutyric acid  .. 
+PF08944 NADPH oxidase subunit p47Phox, C terminal domain<br>The C terminal domain of the phagocyte NADPH oxidase subunit p47Phox contains conserved PxxP motifs that allow binding to SH3 domains, with subsequent activation of the NADPH oxidase, and generation of superoxide, which plays a crucial role in host defense against microbial infection  .. 
+PF08945 Bcl-x interacting, BH3 domain<br>This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11  . This domain is also known as the BH3 domain between residues 146 and 161.. 
+PF08946 Osmosensory transporter coiled coil<br>The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function  .. 
+PF08947 BPS (Between PH and SH2) <br>The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor  .. 
+PF08948 Domain of unknown function (DUF1859)<br>This domain has no known function. It is predominantly found in the N-terminus of bacteriophage spike proteins  .. 
+PF08949 Domain of unknown function (DUF1860)<br>This domain has no known function. It is predominantly found in the C-terminus of bacteriophage spike proteins  .. 
+PF08950 Protein of unknown function (DUF1861)<br>This hypothetical protein, found in bacteria and in the eukaryote Leishmania, has no known function.. 
+PF08951 Enterocin A Immunity<br>Mistry J, Sammut SJ, Coggill P. Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species  . To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc Pfam:PF10439). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin  . The C-terminal hair-pin recognises the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates  . These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, Pfam:PF01721. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids  .. 
+PF08952 Domain of unknown function (DUF1866) <br>This domain, found in Synaptojanin, has no known function.. 
+PF08953 Domain of unknown function (DUF1899)<br>This set of domains is found in various eukaryotic proteins. Function is unknown.. 
+PF08954 Domain of unknown function (DUF1900)<br>This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function  .. 
+PF08955 DUF1901;<br>BofC C-terminal domain. The C-terminal domain of the bacterial protein 'bypass of forespore C' contains a three-stranded beta-sheet and three alpha-helices. Its exact function is, as yet, unknown  .. 
+PF08956 Domain of unknown function (DUF1869)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08958 Domain of unknown function (DUF1871)<br>This set of hypothetical proteins is produced by prokaryotes pertaining to the Bacillus genus.. 
+PF08960 Domain of unknown function (DUF1874)<br>This domain is found in a set of hypothetical viral and bacterial proteins.. 
+PF08961 Domain of unknown function (DUF1875)<br>The MIT domain, found in Nuclear receptor-binding factor 2, has no known function.. 
+PF08962 Domain of unknown function (DUF1876)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08963 Protein of unknown function (DUF1878)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08964 DUF1881;<br>Beta/Gamma crystallin. Mistry J, Sammut SJ, Eberhardt R. This family of beta/gamma crystallins includes the N-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 (Swiss:P54657), which mediates cell-cell adhesion through homophilic interactions  .. 
+PF08965 Domain of unknown function (DUF1870)<br>This domain is found in a set of hypothetical bacterial proteins. It contains a helix-turn-helix domain so may be a DNA-binding protein.. 
+PF08966 Domain of unknown function (DUF1882)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08967 Domain of unknown function (DUF1884)<br>This domain is found in a set of hypothetical bacterial proteins. It shows similarity to the N-terminus of ATP-synthase.. 
+PF08968 Domain of unknown function (DUF1885)<br>This domain is found in a set of hypothetical proteins produced by bacteria of the Bacillus genus.. 
+PF08969 DUF1873;<br>USP8 dimerisation domain. This domain is predominantly found in the amino terminal region of Ubiquitin carboxyl-terminal hydrolase 8 (USP8). It forms a five helical bundle that dimerises  .. 
+PF08970 Sporulation inhibitor A<br>Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilised by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A)  .. 
+PF08971 Glycogen synthesis protein<br>Members of this family are involved in glycogen synthesis in Enterobacteria. The structure of the polypeptide chain comprises a bundle of two parallel amphipathic helices, alpha-1 and alpha-3, and a short hydrophobic helix alpha-2 sandwiched between them  .. 
+PF08972 Domain of unknown function (DUF1902)<br>Members of this family of prokaryotic proteins adopt a fold consisting of one alpha-helix and four beta-strands. Their function has not, as yet, been elucidated  .. 
+PF08973 DUF1893;<br>Domain of unknown function (DUF1893). Mistry J, Sammut SJ, Iyer, LM. A member of the deaminase fold that binds an unknown ligand in  the crystal structure. The protein is ADP-ribosylated at a conserved aspartate  . Contextual analysis suggests that the domain  is likely to bind NAD or ADP ribose either to sense redox states or to function as a regulatory ADP ribosyltransferase  .. 
+PF08974 Domain of unknown function (DUF1877)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08975 DUF1868; <br>Domain of unknown function (DUF1868). This group of 2H-phosphodiesterases comprises a single family typified by the protein mlr3352 from M.loti. Members are also present in various alpha-proteobacteria, Synechocystis, Streptococcus and Chilo iridescent virus. The presence of a member of this predominantly bacterial group in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses (L.M.Iyer, E.V.Koonin and L.Aravind, unpublished observations and these appear to have been acquired from endo-symbiotic or parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for these proteins in regulating the viral tRNA metabolism. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family.. 
+PF08976 Domain of unknown function (DUF1880)<br>This domain is found predominantly in DJ binding protein. It has no known function.. 
+PF08977 Bypass of Forespore C, N terminal<br>The N-terminal domain of 'bypass of forespore C' is composed of a four-stranded beta-sheet covered by an alpha-helix. The beta-sheet has a beta2-beta1-beta4-beta3 topology, where strands beta1 and beta2 and strands beta3 and beta4 are connected by beta-turns, whereas strands beta2 and beta3 are joined by an alpha-helix that runs across one face of the beta-sheet. This domain is similar to the third immunoglobulin G-binding domain of protein G from Streptococcus, the latter belonging to a large and diverse group of cell surface-associated proteins that bind to immunoglobulins. It has been hypothesised that this domain may be a mediator of protein-protein interactions involved in proteolytic events at the cell surface  .. 
+PF08978 Reoviridae VP9<br>This domain is found in various VP9 viral outer-coat proteins. It has no known function.. 
+PF08979 Domain of unknown function (DUF1894)<br>Members of this family have an important role in methanogenesis. They assume an alpha-beta globular structure consisting of six beta-strands and three alpha-helices forming the secondary structural topological arrangement of alpha1-beta1-alpha2-beta2-beta3-beta4-beta5-beta6-alpha3  .. 
+PF08980 Domain of unknown function (DUF1883)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08982 Domain of unknown function (DUF1857)<br>This domain has no known function. It is found in various hypothetical bacterial and fungal proteins.. 
+PF08983 Domain of unknown function (DUF1856)<br>This domain has no known function. It is found in the C-terminal segment of various vasopressin receptors.. 
+PF08984 Domain of unknown function (DUF1858)<br>This domain has no known function. It is found in various hypothetical bacterial proteins.. 
+PF08985 Domain of unknown function (DUF1888)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08986 Domain of unknown function (DUF1889)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08987 Protein of unknown function (DUF1892)<br>Members of this family, that are synthesised by Saccharomycetes, adopt a structure consisting of a four-stranded beta-sheet, with strand order beta2-beta1-beta4-beta3, and two alpha-helices, with an overall topology of beta-beta-alpha-beta-beta-alpha. They have no known function  .. 
+PF08988 Protein of unknown function (DUF1895)<br>The YscE protein, produced by the pathogen Yersinia, assumes a secondary structure composed of two anti-parallel alpha-helices separated by a flexible loop. The function of this protein is, as yet, unknown  .. 
+PF08989 Domain of unknown function (DUF1896)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF08990 Erythronolide synthase docking<br>The N terminal docking domain found in modular polyketide synthase assumes an alpha-helical structure, wherein two alpha-helices are connected by a short loop. Two such N-terminal domains dimerise to form amphipathic parallel alpha-helical coiled coils: dimerisation is essential for protein function  .. 
+PF08991 Domain of unknown function (DUF1903)<br>Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown  .. 
+PF08992 Quinohemoprotein amine dehydrogenase, gamma subunit<br>Members of this family contain a cross-linked, proteinous quinone cofactor, cysteine tryptophylquinone, which is required for catalysis of the oxidative deamination of a wide range of aliphatic and aromatic amines. The domain assumes a globular secondary structure, with two short alpha-helices having many turns and bends  .. 
+PF08993 T4-helicase_N;<br>T4 gene Gp59 loader of gp41 DNA helicase. Bacteriophage T4 gene-59 helicase assembly protein is required for recombination-dependent DNA replication, which is the predominant mode of DNA replication in the late stage of T4 infection. T4 gene-59 helicase assembly protein accelerates the loading of the T4 gene-41 helicase during DNA synthesis by the T4 replication system in vitro. T4 gene-59 helicase assembly protein binds to both T4 gene-41 helicase and T4 gene-32 single-stranded DNA binding protein, and to single and double-stranded DNA. The structure of T4 gene-59 helicase assembly protein reveals a novel alpha-helical bundle fold with two domains of similar size, this being the N-terminal domain that consists of six alpha-helices linked by loop segments and short turns. The surface of the domain contains large regions of exposed hydrophobic residues and clusters of acidic and basic residues. This domain has structural similarity to members of the high-mobility-group (HMG) family of DNA minor groove binding proteins including rat HMG1A and lymphoid enhancer-binding factor, and is required for binding of the helicase to the DNA minor groove  .. 
+PF08994 T4-helicase_C;<br>T4 gene Gp59 loader of gp41 DNA helicase C-term. Bacteriophage T4 gene-59 helicase assembly protein is required for recombination-dependent DNA replication, which is the predominant mode of DNA replication in the late stage of T4 infection. T4 gene-59 helicase assembly protein accelerates the loading of the T4 gene-41 helicase during DNA synthesis by the T4 replication system in vitro.  T4 gene-59 helicase assembly protein binds to both T4 gene-41 helicase and T4 gene-32 single-stranded DNA binding protein, and to single and double-stranded DNA. The structure of T4 gene-59 helicase assembly protein reveals a novel alpha-helical bundle fold with two domains of similar size, this being the C-terminal domain that consists of seven alpha-helices with short intervening loops and turns. The surface of the domain contains large regions of exposed hydrophobic residues and clusters of acidic and basic residues. The hydrophobic region on the 'bottom' surface of the domain near the C-terminal helix binds the leading strand DNA, whilst the hydrophobic region on the 'top' surface of the domain lies between the two arms of the fork DNA, allowing for T4 gene 41 helicase binding and assembly into a hexameric complex around the lagging strand  .. 
+PF08995 Necrosis inducing protein-1<br>Necrosis inducing protein-1, a fungal avirulence protein produced by plants, consists of two parts containing beta-sheets of two and three anti-parallel strands, respectively. Five intramolecular disulfide bonds, stabilise these parts and their position with respect to each other, providing a high level of stability  .. 
+PF08996 DNA Polymerase alpha zinc finger<br>The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. Function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain  .. 
+PF08997 Ubiquinol-cytochrome C reductase complex, 6.4kD protein<br>The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is an essential component of the mitochondrial cellular respiratory chain. This family represents the 6.4kD protein, which may be closely linked to the iron-sulphur protein in the complex and function as an iron-sulphur protein binding factor  .. 
+PF08998 Bacterial epsilon antitoxin<br>The epsilon antitoxin, produced by various prokaryotes, forms part of a postsegregational killing system which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it  .. 
+PF08999 Surfactant protein C, N terminal propeptide<br>The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. It's main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide  .. 
+PF09000 Cytotoxic<br>The cytotoxic domain confers cytotoxic activity to proteins, enabling the formation of nucleolytic breaks in 16S ribosomal RNA. The structure of the domain reveals a highly twisted central beta-sheet elaborated with a short N-terminal alpha-helix  .. 
+PF09001 Domain of unknown function (DUF1890)<br>This domain is found in a set of hypothetical archaeal proteins.. 
+PF09002 Domain of unknown function (DUF1887)<br>This domain is found in a set of hypothetical bacterial proteins.. 
+PF09003 Bacteriophage lambda integrase, N-terminal domain <br>The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage  .. 
+PF09004 Domain of unknown function (DUF1891)<br>This domain is found in a set of hypothetical eukaryotic proteins.. 
+PF09005 Domain of unknown function (DUF1897)<br>This domain is found in Psi proteins produced by Drosophila, and in various eukaryotic hypothetical proteins. It has no known function.. 
+PF09006 Lung surfactant protein D coiled-coil trimerisation<br>This domain, predominantly found in lung surfactant protein D, forms a triple-helical parallel coiled coil, and mediates trimerisation of the protein  .. 
+PF09007 EBP50, C-terminal<br>This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control  .. 
+PF09008 Head binding<br>The head binding domain found in the Phage P22 tailspike protein contains two regular beta-sheets, A and B, oriented nearly perpendicular to each other and composed of five and three strands respectively. The topology of the strands is exclusively antiparallel. The tailspike protein trimerises through this domain, and the direction of the strands with respect to the molecular triad is almost parallel for beta-sheet A, whereas beta-sheet B is perpendicular to the triad, forming a dome-like structure. This domain is dispensable for thermostability and SDS resistance of the intact protein, and its deletion has only minor effects on tailspike folding kinetics  .. 
+PF09009 Exotoxin A catalytic<br>Members of this family, which are found in prokaryotic exotoxin A, catalyse the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis  .. 
+PF09010 Anti-Sigma Factor A<br>Anti-sigma factor A is a transcriptional inhibitor that inhibits sigma 70-directed transcription by weakening its interaction with the core of the host's RNA polymerase. It is an all-helical protein, composed of six helical segments and intervening loops and turns, as well as a helix-turn-helix DNA binding motif, although neither free anti-sigma factor nor anti-sigma factor bound to sigma-70 has been shown to interact directly with DNA. In solution, the protein forms a symmetric dimer of small (10.59 kDa) protomers, which are composed of helix and coil regions and are devoid of beta-strand/sheet secondary structural elements  .. 
+PF09011 DUF1898;<br>Mistry J, Sammut SJ, Coggill P. This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail  .. 
+PF09012 DUF1920; <br>FeoC like transcriptional regulator. This family contains several transcriptional regulators, including FeoC, which contain a HTH motif.  FeoC acts as a [Fe-S] dependant transcriptional repressor  .. 
+PF09013 YopH, N-terminal<br>The N-terminal domain of YopH is a compact structure composed of four alpha-helices and two beta-hairpins. Helices alpha-1 and alpha-3 are parallel to each other and antiparallel to helices alpha-2 and alpha-4. This domain targets YopH for secretion from the bacterium and translocation into eukaryotic cells, and has phosphotyrosyl peptide-binding activity, allowing for recognition of p130Cas and paxillin  .. 
+PF09014 Beta-2-glycoprotein-1 fifth domain<br>The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. It plays an important role in the binding of b2GP-1 to negatively charged compounds and subsequent capture for binding of anti-b2GP-1 antibodies  .. 
+PF09015 NgoMIV restriction enzyme<br>Members of this family are prokaryotic DNA restriction enzymes, exhibiting an alpha/beta structure, with a central region comprising a mixed six-stranded beta-sheet with alpha-helices on each side. A long 'arm' protrudes out of the core of the domain between strands beta2 and beta3 and is mainly involved in the tetramerisation interface of the protein. These restriction enzymes recognise the double-stranded sequence GCCGGC and cleave after G-1  .. 
+PF09016 Pas factor saposin fold<br>Members of this family adopt a compact structure comprising five alpha helices. Charged and polar residues are exposed mostly on the surface, while most of the hydrophobic residues are buried inside the hydrophobic core of the helical bundle. The precise function of this domain is unknown, but it is has been shown to induce secretion of periplasmic proteins, especially collagenase  .. 
+PF09017 Microbial transglutaminase<br>Microbial transglutaminase (MTG) catalyses an acyl transfer reaction by means of a Cys-Asp diad mechanism, in which the gamma-carboxyamide groups of peptide-bound glutamine residues act as the acyl donors. The MTG molecule forms a single, compact domain belonging to the alpha+beta folding class, containing 11 alpha-helices and 8 beta-strands. The alpha-helices and the beta-strands are concentrated mainly at the amino and carboxyl ends of the polypeptide, respectively. These secondary structures are arranged so that a beta-sheet is surrounded by alpha-helices, which are clustered into three regions  .. 
+PF09018 P3 major capsid protein<br>The P3 major capsid protein adopts a 'double-barrel' structure comprising two eight-stranded viral beta-barrels or jelly rolls, each of which contains a 12-residue alpha-helix. This protein then trimerises through a 'trimerisation loop' sequence, and is incorporated within the viral capsid  .. 
+PF09019 EcoRII C terminal<br>The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites  .. 
+PF09020 YopE, N terminal<br>The N terminal YopE domain targets YopE for secretion from the bacterium and translocation into eukaryotic cells  .. 
+PF09021 HutP<br>The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognises three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg2+ ions are also required. These proteins exhibit the structural elements of alpha/beta proteins, arranged in the order: alpha-alpha-beta-alpha-alpha-beta-beta-beta in the primary structure, and the four antiparallel beta-strands form a beta-sheet in the order beta1-beta2-beta3-beta4, with two alpha-helices each on the front (alpha1 and alpha2) and at the back (alpha3 and alpha4) of the beta-sheet  .. 
+PF09022 Staphostatin A<br>The staphostatin A polypeptide chain folds into a slightly deformed, eight-stranded beta-barrel, with strands beta-4 through beta-8 forming an antiparallel sheet while the N-terminus forms a a psi-loop motif. Members of this family constitute a class of cysteine protease inhibitors distinct in the fold and the mechanism of action from any known inhibitors of these enzymes  .. 
+PF09023 Staphostatin B<br>
+PF09025 YopR Core<br>The YopR core domain, predominantly found in the Yersinia pestis virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR  .. 
+PF09026 Cenp-B_dimeris;<br>Centromere protein B dimerisation domain. The centromere protein B (CENP-B) dimerisation domain is composed of two alpha-helices, which are folded into an antiparallel configuration. Dimerisation of CENP-B is mediated by this domain, in which monomers dimerise to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation  .. 
+PF09027 GTPase binding<br>The GTPase binding domain binds to the G protein Cdc42, inhibiting both its intrinsic and stimulated GTPase activity. The domain is largely unstructured in the absence of Cdc42  .. 
+PF09028 Mac 1<br>The bacterial protein Mac 1 adopts an alpha/beta fold, with 14 beta strands and 9 alpha helices. The N-terminal domain is made up predominantly of alpha helices, whereas the C-terminal domain consists predominantly of beta sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity  .. 
+PF09029 5-aminolevulinate synthase presequence<br>The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import  .. 
+PF09030 Creb binding<br>The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery  .. 
+PF09032 Siah interacting protein, N terminal <br>The N terminal domain of Siah interacting protein (SIP) adopts a helical hairpin structure with a hydrophobic core stabilised by a classic knobs-and-holes arrangement of side chains contributed by the two amphipathic helices. Little is known about this domain's function, except that it is crucial for interactions with Siah. It has also been hypothesised that SIP can dimerise through this N terminal domain  .. 
+PF09033 DNA Fragmentation factor 45kDa, C terminal domain<br>The C terminal domain of DNA Fragmentation factor 45kDa (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4). The main function of this domain is the inhibition of DFF40 by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFF40, the C-terminal region of DFF45 is also important for the DFF40-specific folding chaperone activity, as demonstrated by the ability of DFF45 to refold DFF40  .. 
+PF09034 TRADD, N-terminal domain<br>The N terminal domain of 'Tumour necrosis factor receptor type 1 associated death domain protein' (TRADD) folds into an alpha-beta sandwich with a four-stranded beta sheet and six alpha helices, each forming one layer of the structure. The domain allows docking of TRADD onto 'tumour necrosis factor receptor-associated factor' (TRAF): the binding is at the beta-sandwich domain, away from the coiled-coil domain. Binding ensures the recruitment of cIAPs to the signaling complex, which may be important for direct caspase-8 inhibition and the immediate suppression of apoptosis at the apical point of the cascade  .. 
+PF09035 Excisionase from transposon Tn916<br>The phage-encoded excisionase protein Tn916-Xis adopts a winged-helix structure that consists of a three-stranded anti-parallel beta-sheet that packs against a helix-turn-helix (HTH) motif and a third C-terminal alpha-helix. It is encoded for by Tn916, which also codes for the integrase Tn916-Int. The protein interacts with DNA by the insertion of helix alpha-2 into the major groove and the contact of the hairpin that connects strands beta-2 and beta-3 with the adjacent phosphodiester backbone and/or minor groove. Tn916-Xis stimulates phage excision and inhibits viral integration by stabilising distorted DNA structures  .. 
+PF09036 Bcr-Abl oncoprotein oligomerisation domain<br>The Bcr-Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein  .. 
+PF09037 Stf0 sulphotransferase<br>Members of this family are essential for the biosynthesis of sulpholipid-1 in prokaryotes. They adopt a structure that belongs to the sulphotransferase superfamily, consisting of a single domain with a core four-stranded parallel beta-sheet flanked by alpha-helices  .. 
+PF09038 Tumour suppressor p53-binding protein-1 Tudor<br>Members of this family consist of ten beta-strands and a carboxy-terminal alpha-helix. The amino-terminal five beta-strands and the C-terminal five beta-strands adopt folds that are identical to each other. This domain is essential for the recruitment of proteins to double stranded breaks in DNA, which is mediated by interaction with methylated Lys 79 of histone H3  .. 
+PF09039 Mu_I-gamma;<br>Mu DNA binding, I gamma subdomain. Members of this family are responsible for binding the DNA attachment sites at each end of the Mu genome. They adopt a secondary structure comprising a four helix bundle tightly packed around a hydrophobic core consisting of aliphatic and aromatic amino acid residues. Helices 1 and 2 are oriented antiparallel to each other. Helix 3 crosses helices 1 and 2 at angles of 60 and 120 degrees, respectively. Excluding the C-terminal helix 4, the fold of the I-gamma subdomain is remarkably similar to that of the homeodomain family of helix-turn-helix DNA-binding proteins, although their amino acid sequences are completely unrelated  .. 
+PF09040 Gastric H+/K+-ATPase, N terminal domain<br>Members of this family adopt an alpha-helical conformation under hydrophobic conditions. The domain contains tyrosine residues, phosphorylation of which regulates the function of the ATPase. Additionally, the domain also interacts with various structural proteins, including the spectrin-binding domain of ankyrin III  .. 
+PF09041 Aurora-A binding <br>The Aurora-A binding domain binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1  .. 
+PF09042 Titin Z<br>The titin Z domain, that recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly  .. 
+PF09043 D-Lysine 5,6-aminomutase alpha subunit<br>Members of his family are involved in the 1,2 rearrangement of the terminal amino group of DL-lysine and of L-beta-lysine, using adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate as cofactors. The structure is predominantly a PLP-binding TIM barrel domain, with several additional alpha-helices and beta-strands at the N and C termini. These helices and strands form an intertwined accessory clamp structure that wraps around the sides of the TIM barrel and extends up toward the Ado ligand of the Cbl cofactor, providing most of the interactions observed between the protein and the Ado ligand of the Cbl, suggesting that its role is mainly in stabilising AdoCbl in the precatalytic resting state  .. 
+PF09044 Kp4<br>Members of this fungal family of toxins specifically inhibit voltage-gated calcium channels in mammalian cells. They adopt an alpha/beta-sandwich structure, comprising a five-stranded antiparallel beta-sheet with two antiparallel alpha-helices lying at approximately 45 degrees to these strands  .. 
+PF09045 L27_2<br>The L27_2 domain is a protein-protein interaction domain capable of organising scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes. L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer  .. 
+PF09046 AvrPtoB E3 ubiquitin ligase<br>The E3 ubiquitin ligase domain found in the bacterial protein AvrPtoB inhibits immunity-associated programmed cell death (PCD) when translocated into plant cells, probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. The structure of this domain reveals a globular fold centred on a four-stranded beta-sheet that packs against two helices on one face and has three very extended loops connecting the elements of secondary structure, with remarkable homology to the RING-finger and U-box families of proteins involved in ubiquitin ligase complexes in eukaryotes  .. 
+PF09047 MEF2 binding<br>The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription  .. 
+PF09048 Cro<br>Members of this family are involved in the repression of transcription by binding as a homodimer to palindromic DNA operator sites in phage lambda: they repress genes expressed in early phage development and are necessary for the late stage of lytic growth. These proteins have a secondary structure consisting of three alpha-helices and three beta-sheets, and dimerise through interactions between the two antiparallel beta-strands  .. 
+PF09049 Stannin transmembrane<br>Members of this family consist of a single highly hydrophobic transmembrane helix that transverses the lipid bilayer at a 20 degree angle with respect to the membrane normal. They contain a conserved cysteine residue (Cys32) that, together with Cys34 found in the stannin unstructured linker domain, constitutes the putative trimethyltin-binding site that resides at the end of the transmembrane domain close to the lipid/solvent interface  .. 
+PF09050 Stannin unstructured linker<br>Members of this family are unstructured, acting as connectors of the stannin helical domains. They contain a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade  .. 
+PF09051 Stannin cytoplasmic<br>Members of this family consist of a distorted cytoplasmic helix that is partially absorbed into the plane of the lipid bilayer with a tilt angle of approximately 80 degrees from the membrane normal. They interact with the surface of the lipid bilayer, and contribute to the initiation of the apoptotic cascade on binding of the unstructured linker domain to dimethyltin  .. 
+PF09052 Salmonella invasion protein A<br>Salmonella invasion protein A is an actin-binding protein that contributes to host cytoskeletal rearrangements by stimulating actin polymerisation and counteracting F-actin destabilising proteins. Members of this family possess an all-helical fold consisting of eight alpha-helices arranged so that six long, amphipathic helices form a compact fold that surrounds a final, predominantly hydrophobic helix in the middle of the molecule  .. 
+PF09053 CagZ<br>CagZ is a 23 kDa protein consisting of a single compact L-shaped domain, composed of seven alpha-helices that run antiparallel to each other. 70% of the residues are in alpha-helix conformation and no beta-sheet is present. CagZ is essential for the translocation of the pathogenic protein CagA into host cells  .. 
+PF09055 Nickel-containing superoxide dismutase<br>Nickel containing superoxide dismutase (NiSOD) is a metalloenzyme containing a hexameric assembly of right-handed 4-helix bundles of up-down-up-down topology with an N-terminal His-Cys-X-X-Pro-Cys-Gly-X-Tyr motif that chelates the active site Ni ions. NiSOD catalyses the disproportionation of superoxide to peroxide and molecular oxygen through alternate oxidation and reduction of Ni, protecting cells from the toxic products of aerobic metabolism  .. 
+PF09056 Prokaryotic phospholipase A2<br>The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments  .. 
+PF09057 Second Mitochondria-derived Activator of Caspases<br>Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution  .. 
+PF09058 L27_1<br>The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form specific heterotetrameric complexes, in which each domain contains three alpha-helices  .. 
+PF09059 TyeA<br>Members of this family are composed of two pairs of parallel alpha-helices, and interact with the bacterial protein YopN via hydrophobic residues located on the helices. Association of TyeA with the C terminus of YopN is accompanied by conformational changes in both polypeptides that create order out of disorder: the resulting structure then serves as an impediment to type III secretion of YopN  .. 
+PF09060 L27_N<br>The L27_N domain plays a role in the biogenesis of tight junctions and in the establishment of cell polarity in epithelial cells. Each L27_N domain consists of three alpha-helices, the first two of which form an antiparallel coiled-coil. Two L27 domains come together to form a four-helical bundle with the antiparallel coiled-coils formed by the first two helices. The third helix of each domain forms another coiled-coil packing at one end of the four-helix bundle, creating a large hydrophobic interface: the hydrophobic interactions are the major force that drives heterodimer formation  .. 
+PF09062 PI-PfuI Endonuclease subdomain<br>The endonuclease subdomain, found in the prokaryotic protein ribonucleotide reductase, assumes an alpha-beta-beta-alpha-beta-beta-alpha-alpha topology. The four stranded beta-sheet forms a saddle-shaped surface and assembles together through an interface made of alpha-helices. The presence of 14 basic residues on the surface of the beta-sheets suggests that this large groove may be involved in DNA binding  .. 
+PF09063 Phage PP7 coat protein<br>Members of this family form the capsid of P. aeruginosa phage PP7. They adopt a secondary structure consisting of a six stranded beta sheet and an alpha helix  .. 
+PF09064 Thrombomodulin like fifth domain, EGF-like<br>Members of this family adopt a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with  thrombin, and subsequent activation of protein-C  .. 
+PF09065 Haemadin<br>Members of this family adopt a secondary structure consisting of five short beta-strands (beta1-beta5), which are arranged in two antiparallel distorted sheets formed by strands beta1-beta4-beta5 and beta2-beta3 facing each other. This beta-sandwich is stabilised by six enclosed cysteines arranged in a [1-2, 3-5, 4-6] disulphide pairing resulting in a disulphide-rich hydrophobic core that is largely inaccessible to bulk solvent. The close proximity of disulfide bonds [3-5] and [4-6] organises haemadin into four distinct loops. The N-terminal segment of this domain binds to the active site of thrombin, inhibiting it  .. 
+PF09066 Beta2-adaptin appendage, C-terminal sub-domain<br>Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15)  .. 
+PF09067 Erythropoietin receptor, ligand binding<br>Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions  .. 
+PF09068 efhand_1; EF_hand_2;<br>
+PF09069 efhand_2;<br>
+PF09070 PFU (PLAA family ubiquitin binding)<br>Pfam-B_5813 (release 20.0). This domain is found N terminal to Pfam:PF08324 and binds to ubiquitin  .. 
+PF09071 Alpha-amylase, C terminal<br>Members of this family, which are found in the prokaryotic protein glycosyltrehalose trehalohydrolase, assume a gamma-crystallin-type fold with a five-stranded anti-parallel beta-sheet that packs against the C-terminal side of a beta-alpha barrel. This domain is common to family 13 glycosidases and typically contains a five to ten strand beta-sheet, however its precise fold varies  .. 
+PF09072 Translation machinery associated TMA7<br>TMA7 plays a role in protein translation. Deletions of the TMA7 gene results in altered protein synthesis rates  .. 
+PF09073 BUD22<br>BUD22 has been shown in yeast to be a nuclear protein involved in bud-site selection.  It plays a role in positioning the proximal bud pole signal  . More recently it has been shown to be involved in ribosome biogenesis [2,3].. 
+PF09074 Mer2<br>Mer2 (Rec107) forms part of a complex  that is required for meiotic double strand DNA break formation.  Mer2 increases in abundance and is phosphorylated during the prophase phase of cell division  . Blocking double strand break formation results in delayed dephosphorylation and dissociation of Mer2 from the chromosome  .. 
+PF09075 Heat-stable enterotoxin B, secretory<br>Members of this family assume a helical secondary structure, with two alpha helices forming a disulphide crosslinked alpha-helical hairpin. The disulphide bonds are crucial for the toxic activity of the protein, and are required for maintenance of the tertiary structure, and subsequent interaction with the particulate form of guanylate cyclase, increasing cyclic GMP levels within the host intestinal epithelial cells  .. 
+PF09076 Sklp_toxin;<br>Beta/Gamma crystallin. Sammut SJ, Eberhardt R. Members of this family assume a beta-gamma-crystallin fold [1,2], wherein nine beta-strands are connected by loop, and are separated into two sheets, each sheet forming the Greek key motif. The two Greek key motifs face each other in the global topology. The three-dimensional structure of the molecule is a 'sandwich'-shaped beta-barrel structure: hydrophobic side-chains are packed in the large interface area of the beta-sheets. In Streptomyces killer toxin-like protein domain confers a cytocidal effect to the toxin, causing cell death in both budding and fission yeasts, and morphological changes in yeasts and filamentous fungi  .  This family also includes chitin-biding antifungal proteins [2-3].. 
+PF09077 Mu B transposition protein, C terminal <br>The C terminal domain of the B transposition protein from Bacteriophage Mu comprises four alpha-helices arranged in a loosely packed bundle, where helix alpha1 runs parallel to alpha3, and anti-parallel to helices alpha2 and alpha4. The domain allows for non-specific binding of Mu to double-stranded DNA, allowing for integration into the bacterial genome, and mediates dimerisation of the protein  .. 
+PF09078 CheY binding<br>Members of this family adopt a secondary structure consisting of an open-face beta/alpha sandwich, with four antiparallel beta-strands and two alpha-helices. They bind to a corresponding domain on CheY, with subsequent phosphorylation of the CheY Asp57 residue, and activation of CheY, which then affects flagellar rotation  .. 
+PF09079 CDC6, C terminal <br>The C terminal domain of CDC6 assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate Cdc6 activity  .. 
+PF09080 K cyclin, C terminal<br>Members of this family adopt a secondary structure consisting of a five alpha-helix cyclin fold. Interaction with cyclin dependent kinases (CDKs) at a PSTAIRE sequence motif within the catalytic cleft of CDK results in the regulation of CDK activity  .. 
+PF09081 Domain of unknown function (DUF1921)<br>This domain, which is found in a set of prokaryotic amylases, has no known function  .. 
+PF09082 Domain of unknown function (DUF1922)<br>Members of this family consist of a beta-sheet region followed by an alpha-helix and an unstructured C-terminus. The beta-sheet region contains a CXCX...XCXC sequence with Cys residues located in two proximal loops and pointing towards each other. This precise function of this set of bacterial proteins is, as yet, unknown  .. 
+PF09083 Domain of unknown function (DUF1923)<br>Members of this family are found in maltosyltransferases, and adopt a secondary structure consisting of eight antiparallel beta-strands, which form an open-sided 'jelly roll' Greek key beta-barrel. Their exact function is, as yet, unknown  .. 
+PF09084 NMT1/THI5 like<br>Pfam-B_2797 (release 20.0). This family contains the NMT1 and THI5 proteins.  These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine    .  They are regulated by thiamine  .. 
+PF09085 Adhesion molecule, immunoglobulin-like<br>Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues  .. 
+PF09086 Domain of unknown function (DUF1924)<br>This domain is found in a set of bacterial proteins, including Cytochrome c-type protein. It is functionally uncharacterised.. 
+PF09087 Cyclomaltodextrinase, N-terminal<br>Members of this family assume a beta-sandwich structure composed of the eight antiparallel beta-strands. A ten residue linker is also present at the C-terminal end, which connects the N terminal domain to a distal domain in the protein. This domain participates in oligomerisation of the protein, wherein the N-terminal domain of one subunit contacts the active centre of the other subunit, and is also required for binding of cyclodextrin to substrate  .. 
+PF09088 MIF4G like<br>Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices  .. 
+PF09089 Phage short tail fibre protein gp12, middle domain<br>Members of this family adopt a right-handed triple-stranded beta-helix fold, and are found in the middle of the phage short tail fibre protein gp12  .. 
+PF09090 MIF4G like<br>Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices  .. 
+PF09092 Lyase, N terminal<br>Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a jelly-roll fold topology consisting of a two-layered bent beta-sheet sandwich with one short alpha-helix. The convex beta sheet is composed of five antiparallel strands, whilst the concave beta-sheet contains five antiparallel beta-strands with a loop between two consecutive strands folding back onto the concave surface. This domain is required for binding of the protein to long glycosaminoglycan chains  .. 
+PF09093 Lyase, catalytic<br>Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a helical structure, with fifteen alpha-helices which are at least two turns long and several short helical turns. The bulk of the domain is formed by ten alpha-helices forming five hairpin-like pairs and arranged into an incomplete toroid, the (alpha/alpha)5 fold. Additionally, two long and two short alpha-helices at the N terminus of the domain wrap around the toroid. At the C-terminal end of the toroid there is one additional short alpha-helix. This domain is required for degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucoronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups  .. 
+PF09094 Domain of unknown function (DUF1925)<br>Members of this family, which are found in a set of prokaryotic transferases, adopt an immunoglobulin/albumin-binding domain-like fold, with a bundle of three alpha-helices. Their function is, as yet, unknown  .. 
+PF09095 Domain of unknown function (DUF1926)<br>Members of this family, which are found in a set of prokaryotic transferases, adopt a beta-sandwich fold, in which two layers of anti-parallel beta-sheets are arranged in a nearly parallel fashion. The exact function of this family is, as yet, unknown, however it has been proposed that they may play a role in transglycosylation reactions  .. 
+PF09096 Baseplate structural protein, domain 2<br>Members of this family adopt a beta barrel structure with a Greek key topology, which is topologically similar to the FMN-binding split barrel. They are structural component of the viral baseplate, predominantly found in the structural protein gp27  .. 
+PF09097 Baseplate structural protein, domain 1<br>Members of this family adopt a beta barrel structure with a Greek key topology, which is topologically similar to the FMN-binding split barrel. They are structural component of the viral baseplate, predominantly found in the structural protein gp27  .. 
+PF09098 Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding<br>Sammut SJ, Eberhardt R. Members of this family are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase. They have a predominantly alpha-helical structure and can be divided into two subdomains, each binding a haem C group via a conserved CXXCH motif [1,2].. 
+PF09099 DUF1927;<br>Quinohemoprotein amine dehydrogenase, alpha subunit domain III. Sammut SJ, Eberhardt R. Members of this family, which are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase, adopt an immunoglobulin-like beta-sandwich fold, with seven strands arranged into two beta sheets; the fold is possibly related to the immunoglobulin and/or fibronectin type III superfamilies. The precise function of this domain has not, as yet, been defined [1,2].. 
+PF09100 DUF1928;<br>Quinohemoprotein amine dehydrogenase, alpha subunit domain IV. Sammut SJ, Eberhardt R. Members of this family, which are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase, adopt an immunoglobulin-like beta-sandwich fold, with seven strands arranged into two beta sheets; the fold is possibly related to the immunoglobulin and/or fibronectin type III superfamilies. The precise function of this domain has not, as yet, been defined [1,2].. 
+PF09101 Exotoxin A binding<br>Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for binding of the toxin to the alpha-2-macroglobulin receptor, with subsequent internalisation into endosomes. The domain adopts a thirteen-strand antiparallel beta jelly roll topology, which belongs to the Concanavalin A-like lectins/glucanases fold superfamily  .. 
+PF09102 Exotoxin A, targeting<br>Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for transmembrane targeting of the toxin, as well as transmembrane translocation of the catalytic domain into the cytoplasmic compartment. A furin cleavage site is present within the domain: cleavage generates a 37 kDa carboxy-terminal fragment, which includes the enzymatic domain, which is then is translocated into the cytoplasm. The domain adopts a helical structure, with six alpha-helices forming a bundle  .. 
+PF09103 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1<br>Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome  .. 
+PF09104 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3<br>Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding  .. 
+PF09105 Elongation factor SelB, winged helix <br>Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding  .. 
+PF09106 Elongation factor SelB, winged helix <br>Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding  .. 
+PF09107 Elongation factor SelB, winged helix <br>Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding  .. 
+PF09108 Switch protein XOL-1, N-terminal<br>Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and six antiparallel beta sheets, in a beta-alpha-beta-beta-beta-alpha-beta-alpha-alpha-alpha-beta arrangement. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like  .. 
+PF09109 Switch protein XOL-1, GHMP-like<br>Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and seven antiparallel beta sheets, in a beta-alpha-beta-alpha-alpha-alpha-beta-beta-alpha-beta-beta-beta arrangement. The fold of this family is structurally similar to that found in the C-terminal domain of GHMP Kinase  .. 
+PF09110 HAND<br>The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. The domain confers DNA and nucleosome binding properties to the protein  .. 
+PF09111 SLIDE<br>The SLIDE domain adopts a secondary structure comprising a main core of three alpha-helices. It has a role in DNA binding, contacting DNA target sites similar to c-Myb (Pfam:PF00249) repeats or homeodomains  .. 
+PF09112 PngaseF_N;<br>Peptide-N-glycosidase F, N terminal. Members of this family adopt an eight-stranded antiparallel beta jelly roll configuration, with the beta strands arranged into two sheets. They are similar in topology to many viral capsid proteins, as well as lectins and several glucanases. The domain allows the protein to bind sugars and catalyses the complete removal of N-linked oligosaccharide chains from glycoproteins  .. 
+PF09113 PngaseF_C;<br>Peptide-N-glycosidase F, C terminal. Members of this family adopt an eight-stranded antiparallel beta jelly roll configuration, with the beta strands arranged into two sheets. They are similar in topology to many viral capsid proteins, as well as lectins and several glucanases. The domain allows the protein to bind sugars and catalyses the complete removal of N-linked oligosaccharide chains from glycoproteins  .. 
+PF09114 Transcription factor MotA, activation domain<br>Members of this family of viral protein domains are implicated in transcriptional activation. They are almost completely alpha-helical, with five alpha-helices and a short, two-stranded, beta-ribbon. Four alpha helices (alpha1, alpha3, alpha4 and alpha5) are amphipathic and pack their hydrophobic surfaces around the central helix alpha2  .. 
+PF09115 DNA polymerase III, delta subunit, C terminal<br>Members of this family, which are predominantly found in prokaryotic DNA polymerase III, assume an alpha helical structure, with a core of five alpha helices, and an additional small helix. They are essential for the formation of the polymerase clamp loader  .. 
+PF09116 gp45 sliding clamp, C terminal<br>Members of this family are essential for the interaction of the gp45 sliding clamp with the corresponding polymerase. They adopt a DNA clamp fold, consisting of two alpha helices and two beta sheets - the fold is duplicated and has internal pseudo two-fold symmetry  .. 
+PF09117 MiAMP1<br>MiAMP1 is a highly basic protein from the nut kernel of Macadamia integrifolia which inhibits the growth of several microbial plant pathogens in vitro while having no effect on mammalian or plant cells. It consists of eight beta-strands which are arranged in two Greek key motifs. These Greek key motifs then associate to form a Greek key beta-barrel  .. 
+PF09118 Domain of unknown function (DUF1929)<br>Members of this family adopt a secondary structure consisting of a bundle of seven, mostly antiparallel, beta-strands surrounding a hydrophobic core. The 7 strands are arranged in 2 sheets, in a Greek-key topology. Their precise function, has not, as yet, been defined, though they are mostly found in sugar-utilising enzymes, such as galactose oxidase  .. 
+PF09119 SicP binding<br>Members of this family bind the chaperone SicP, which is required both to maintain the stability of SptP, as well as to ensure the eventual secretion of the protein. The domain is found in the Salmonella effector protein SptP, which interacts with SicP chaperone dimers mainly through four regions of its chaperone-binding domain. The structure of the SptP-SicP complex contains four molecules of SicP, aligned in a linear fashion and arranged in two sets of tightly bound homodimers that bind two SptP molecules. The SicP homodimers do not interact with each other, but are held together by a molecular interface formed between two SptP molecules. Each SptP molecule is wrapped around by three SicP chaperones (two chaperones from one homodimer and a third one from the opposite homodimer pair)  .. 
+PF09121 Tower<br>Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA  .. 
+PF09122 Domain of unknown function (DUF1930)<br>Members of this family are found in 3-mercaptopyruvate sulfurtransferase, and have no known function. They adopt a structure consisting of a four-stranded antiparallel beta-sheet and an alpha-helix, arranged in a beta(2)-alpha-beta(2) fashion, and bearing a remarkable structural similarity to the FK506-binding protein class of peptidylprolyl cis/trans-isomerase  .. 
+PF09123 Domain of unknown function (DUF1931)<br>Members of this family, which are found in a set of hypothetical bacterial proteins, contain a core of six alpha-helices, where one central helix is surrounded by the other five. The exact function of this family has not, as yet, been determined  .. 
+PF09124 T4 recombination endonuclease VII, dimerisation<br>Members of this family, which are predominantly found in Bacteriophage T4 recombination endonuclease VII, adopt a helical secondary structure, with three alpha helices oriented parallel to each other. They mediate dimerisation of the protein, as well as binding to the DNA major groove  .. 
+PF09125 Cytochrome C oxidase subunit II, transmembrane<br>Members of this family adopt a tertiary structure consisting of two antiparallel transmembrane helices, in a transmembrane helix hairpin fold  .. 
+PF09126 Restriction endonuclease NaeI <br>Members of this family adopt a secondary structure consisting of nine alpha-helices, six 3-10 helices and 13 beta-strands. They bind two GCC-CGG recognition sequences to cleave DNA into blunt-ended products  .. 
+PF09127 Leukotriene A4 hydrolase, C-terminal<br>Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase  .. 
+PF09128 Regulator of G protein signalling-like domain<br>Members of this family adopt a structure consisting of twelve helices that fold into a compact domain that contains the overall structural scaffold observed in other RGS proteins and three additional helical elements that pack closely to it. Helices 1-9 comprise the RGS (Pfam:PF00615) fold, in which helices 4-7 form a classic antiparallel bundle adjacent to the other helices. Like other RGS structures, helices 7 and 8 span the length of the folded domain and form essentially one continuous helix with a kink in the middle. Helices 10-12 form an apparently stable C-terminal extension of the structural domain, and although other RGS proteins lack this structure, these elements are intimately associated with the rest of the structural framework by hydrophobic interactions. Members of the family bind to active G-alpha proteins, promoting GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways  .. 
+PF09129 Cholesterol oxidase, substrate-binding<br>The substrate-binding domain found in Cholesterol oxidase is composed of an eight-stranded mixed beta-pleated sheet and six alpha-helices. This domain is positioned over the isoalloxazine ring system of the FAD cofactor bound by FAD_binding_4 (PF:PF01565) and forms the roof of the active site cavity, allowing for catalysis of oxidation and isomerisation of cholesterol to cholest-4-en-3-one  .. 
+PF09130 Domain of unknown function (DUF1932)<br>This domain is found in a set of hypothetical prokaryotic proteins. Its exact function has not, as yet, been described.. 
+PF09131 Bacillus thuringiensis delta-Endotoxin, middle domain<br>Members of this family adopt a structure consisting of three four-stranded beta-sheets, each with a Greek key fold, with internal pseudo threefold symmetry. Thus they act as a receptor binding beta-prism, binding to insect-specific receptors of gut epithelial cells  .. 
+PF09132 BmKX<br>Members of this family assume a structure adopted by most short-chain scorpion toxins, consisting of a cysteine-stabilised alpha/beta scaffold consisting of a short 3-10-helix and a two-stranded antiparallel beta-sheet. They are predominantly found in short-chain scorpion toxins, and their biological method of action has not, as yet, been defined  .. 
+PF09133 SANTA (SANT Associated)<br>The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota.  It is sometimes found in association with the SANT domain (Pfam:PF00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling  .  Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes  .  Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions  .. 
+PF09134 Invasin, domain 3<br>Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, arranged in a Greek-key topology. It forms part of the extracellular region of the protein, which can be expressed as a soluble protein (Inv497) that binds integrins and promotes subsequent uptake by cells when attached to bacteria  .. 
+PF09135 Alb1<br>Alb1 is a nuclear shuttling factor involved in ribosome biogenesis  .. 
+PF09136 Glucodextranase, domain B<br>Members of this family adopt a structure consisting of seven/eight-strand antiparallel beta-sheets, in a Greek-key topology, similar to the immunoglobulin beta-sandwich fold. They act as cell wall anchors, where they interact with the S-layer present in the cell wall of Gram-positive bacteria by hydrophobic interactions. In glucodextranase, Domain B is buried in the S-layer, and a flexible linker located between domain B and the catalytic unit confers motion to the catalytic unit, which is capable of efficient hydrolysis of the substrates located close to the cell surface  .. 
+PF09137 Glucodextranase, domain N<br>Members of this family, which are uniquely found in bacterial and archaeal glucoamylases and glucodextranases, adopt a structure consisting of 17 antiparallel beta-strands. These beta-strands are divided into two beta-sheets, and one of the beta-sheets is wrapped by an extended polypeptide, which appears to stabilise the domain. Members of this family are mainly concerned with catalytic activity, hydrolysing alpha-1,6-glucosidic linkages of dextran to release beta-D-glucose from the non-reducing end via an inverting reaction mechanism  .. 
+PF09138 Urm1 (Ubiquitin related modifier)<br>Pfam-B_16507 (release 20.0). Urm1 is a ubiquitin related protein that modifies proteins in the yeast ubiquitin-like pathway urmylation  . Structural comparisons and phylogenetic analysis of the ubiquitin superfamily has indicated that Urm1 has the most conserved structural and sequence features of the common ancestor of the entire superfamily  .. 
+PF09139 Mitochondrial matrix Mmp37<br>Pfam-B_15301 (release 20.0). MMp37 is a mitochondrial matrix protein that functions in the translocation of proteins across the mitochondrial inner membrane  . It has been shown that MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane  .. 
+PF09140 ATPase MipZ<br>Mistry J, Thanbichler M. Pfam-B_23525 (release 20.0). MipZ is an ATPase that forms a complex with the chromosome partitioning protein ParB near the chromosomal origin of replication  .  It is responsible for the temporal and spatial regulation of FtsZ ring formation  .. 
+PF09141 Talin, middle domain<br>Members of this family adopt a structure consisting of five alpha helices that fold into a bundle. They contain a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin  .. 
+PF09142 tRNA Pseudouridine synthase II, C terminal<br>The C terminal domain of tRNA Pseudouridine synthase II adopts a PUA (Pfam:PF01472) fold, with a four-stranded mixed beta-sheet flanked by one alpha-helix on each side. It allows for binding of the enzyme to RNA, as well as stabilisation of the RNA molecule  .. 
+PF09143 AvrPphF-ORF-2<br>Members of this family of plant pathogenic proteins adopt an elongated structure somewhat reminiscent of a mushroom that can be divided into 'stalk' and 'head' subdomains. The stalk subdomain is composed of the N-terminal helix (alpha1) and beta strands beta3-beta4. An antiparallel beta sheet (beta5, beta7-beta8) forms the base of the head subdomain that interacts with the stalk. A pair of twisted antiparallel beta sheets (beta1 and beta6; beta2 and beta9/9') supported by alpha2 form the dome of the head. The head subdomain possesses weak structural similarity with the catalytic portion of a number of ADP-ribosyltransferase toxins  .. 
+PF09144 Yersinia pseudotuberculosis mitogen<br>Members of this family of Yersinia pseudotuberculosis mitogens adopt a sandwich structure consisting of nine strands in two beta sheets, in a jelly-roll topology. As with other superantigens, they are able to excessively activate T cells by binding to the T cell receptor  .. 
+PF09145 Ubiquitin-associated<br>Ubiquitin associated domains contain approximately 40 residues and bind ubiquitin noncovalently. They adopt a secondary structure consisting of three alpha-helices, and have been identified in various modular proteins involved in protein trafficking, clathrin assembly/disassembly, DNA repair, proteasomal degradation, and cell cycle regulation  .. 
+PF09147 Domain of unknown function (DUF1933)<br>Members of this family are predominantly found in carbapenam synthetase, and are composed of two antiparallel six-stranded beta-sheets that form a sandwich, flanked on each side by two alpha-helices. Their exact function has not, as yet, been determined  .. 
+PF09148 Domain of unknown function (DUF1934)<br>Members of this family are found in a set of hypothetical bacterial proteins. Their precise function has not, as yet, been defined.. 
+PF09149 Domain of unknown function (DUF1935)<br>Members of this family are found in various bacterial and eukaryotic hypothetical proteins, as well as in the cysteine protease calpain. Their exact function has not, as yet, been defined.. 
+PF09150 Orange carotenoid protein, N-terminal <br>Members of this family adopt an alpha-helical structure consisting of two four-helix bundles. They are predominantly found in prokaryotic orange carotenoid protein, and carotenoid binding proteins  .. 
+PF09151 Domain of unknown function (DUF1936)<br>This domain is found in a set of hypothetical Archaeal proteins. Its exact function has not, as yet, been defined. It possesses a zinc ribbon fold.. 
+PF09152 Domain of unknown function (DUF1937)<br>This domain is found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been described.. 
+PF09153 Domain of unknown function (DUF1938)<br>Members of this family, which are predominantly found in the archaeal protein O6-alkylguanine-DNA alkyltransferase, adopt a secondary structure consisting of a three stranded antiparallel beta-sheet and three alpha helices. Their exact function has not, as yet, been defined, though it has been postulated that they confer thermostability to the archaeal protein  .. 
+PF09154 Domain of unknown function (DUF1939)<br>Members of this family, which are predominantly found in Archaeal amylase, adopt a secondary structure consisting of an eight-stranded antiparallel beta-sheet containing a Greek key motif. Their exact function has not, as yet, been determined  .. 
+PF09155 Domain of unknown function (DUF1940)<br>Members of this family adopt a secondary structure consisting of six alpha helices, with four long helices (alpha1, alpha2, alpha5, alpha6) form a left-handed, antiparallel alpha helical bundle. The function of this family of Archaeal hypothetical proteins has not, as yet, been defined  .. 
+PF09156 Anthrax toxin lethal factor, middle domain<br>Members of this family, which are predominantly found in anthrax toxin lethal factor, adopt a structure consisting of a core of antiparallel beta sheets and alpha helices. They form a long deep groove within the protein that anchors the 16-residue N-terminal tail of MAPKK-2 before cleavage. It has been noted that this domain resembles the ADP-ribosylating toxin from Bacillus cereus, but the active site has been modified to augment substrate recognition  .. 
+PF09157 Pseudouridine synthase II TruB, C-terminal<br>Members of this family adopt a secondary structure consisting of a four-stranded beta sheet and one alpha helix. They are predominantly RNA-binding domains, mostly found in Pseudouridine synthase II TruB  .. 
+PF09158 Bacteriophage T4 MotA, C-terminal<br>Members of this family adopt a compact alpha/beta structure comprising three alpha-helices and six beta-strands in the order: alpha1-beta1-beta2-beta3-beta4-alpha2-beta5-beta6-alpha3. The beta-strands form a single anti-parallel beta-sheet and the three alpha-helices pack side-by-side onto one surface of the beta-sheet. In this architecture, the domain's hydrophobic core is at the sheet-helix interface, and the second surface of the beta-sheet is completely exposed. The domain is a DNA-binding motif, with a consensus sequence containing nine base pairs (5'-TTTGCTTTA-3'), that appears to bind to various mot boxes, allowing access to the minor groove towards the 5'-end of this sequence and the major groove towards the 3'-end  .. 
+PF09159 Mitochondrial resolvase Ydc2 / RNA splicing MRS1<br>Members of this family adopt a secondary structure consisting of two beta sheets and one alpha helix, arranged as a beta-alpha-beta motif.  Each beta sheet has five strands, arranged in a 32145 order, with the second strand being antiparallel to the rest. Mitochondrial resolvase Ydc2 is capable of resolving Holliday junctions and cleaves DNA after 5'-CT-3' and 5'-TT-3' sequences  .  This family also contains the mitochondrial RNA-splicing protein MRS1 which is involved in the excision of group I introns [2-3].. 
+PF09160 FimH, mannose binding<br>Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose  .. 
+PF09162 Tap, RNA-binding<br>Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element  .. 
+PF09163 Formate dehydrogenase N, transmembrane<br>Members of this family are predominantly found in the beta subunit of formate dehydrogenase, and consist of a single transmembrane helix. They act as a transmembrane anchor, and allow for conduction of electrons within the protein  .. 
+PF09164 Vitamin D binding protein, domain III<br>Members of this family are predominantly found in Vitamin D binding protein, and adopt a multihelical structure. They are required for formation of an actin 'clamp', allowing the protein to bind to actin  .. 
+PF09165 Ubiquinol-cytochrome c reductase 8 kDa, N-terminal<br>Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain  .. 
+PF09166 Biliverdin reductase, catalytic<br>Members of this family adopt a structure consisting of four alpha helices and six beta sheets, in an alpha-beta-alpha-alpha-alpha-beta-beta-beta-beta-beta arrangement. They contain a catalytic active site, capable of reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor  .. 
+PF09167 Domain of unknown function (DUF1942)<br>Members of this family of bacterial proteins assume a beta-sandwich structure consisting of two antiparallel beta-sheets similar to an immunoglobulin-like fold, with an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of these beta-strands form an antiparallel beta-sheet. The exact function of this family of proteins is unkown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation  .. 
+PF09168 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal<br>Members of this family adopt a secondary structure consisting of a helical bundle of eight alpha helices and three beta strands, the last alpha helix connecting to the first strand of the catalytic domain. The first strand of the N-terminus also forms a small parallel beta sheet with strand 5' of catalytic domain. The domain mediates dimerisation of the protein, with two proline residues present in the domain being critical for interaction  .. 
+PF09169 BRCA2, helical<br>Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (Pfam:PF09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome  .. 
+PF09170 DUF1879;<br>CST, Suppressor of cdc thirteen homolog, complex subunit STN1. STN1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required for protecting telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity on their own. In addition to telomere protection, the CST complex probably has a more general role in DNA metabolism at non-telomeric sites.. 
+PF09171 Domain of unknown function (DUF1886)<br>This domain is predominantly found in the Archaeal protein N-glycosylase/DNA lyase.. 
+PF09172 Domain of unknown function (DUF1943)<br>Members of this family adopt a structure consisting of several large open beta-sheets. Their exact function has not, as yet, been determined  .. 
+PF09173 Initiation factor eIF2 gamma, C terminal<br>Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA  .. 
+PF09174 Maf1 regulator<br>Maf1 is a negative regulator of RNA polymerase III   .  It targets the initiation factor TFIIIB  .. 
+PF09175 Domain of unknown function (DUF1944)<br>Members of this family adopt a structure consisting of several large open beta-sheets. Their exact function has not, as yet, been determined  .. 
+PF09176 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal<br>Members of this family adopt a alpha-beta structure, with a core comprising three alpha/beta/alpha layers, in which each sheet contains four strands. They are predominantly found in prokaryotic methylene-tetrahydromethanopterin dehydrogenase, which catalyses the dehydrogenation of methylene-tetrahydromethanopterin and the reversible dehydrogenation of methylene-H(4)F  .. 
+PF09177 Syntaxin 6, N-terminal<br>Members of this family, which are found in the amino terminus of various SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that they regulate the SNARE motif, as well as mediate various protein-protein interactions involved in membrane-transport  .. 
+PF09178 Domain of unknown function (DUF1945)<br>Members of this family, which are predominantly found in prokaryotic 4-alpha-glucanotransferase, adopt a structure composed of six antiparallel beta-strands, four of which form a beta-sheet and another two form a type I' beta-hairpin. The role of this family of domains, has not, as yet, been defined  .. 
+PF09179 DUF1946; <br>TilS substrate binding domain. This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.. 
+PF09180 Prolyl-tRNA synthetase, C-terminal<br>Members of this family are predominantly found in prokaryotic prolyl-tRNA synthetase. They contain a zinc binding site, and adopt a structure consisting of alpha helices and antiparallel beta sheets arranged in 2 layers, in a beta-alpha-beta-alpha-beta motif  .. 
+PF09181 Prolyl-tRNA synthetase, C-terminal<br>Members of this family are predominantly found in prokaryotic prolyl-tRNA synthetase. They contain a zinc binding site, and adopt a structure consisting of alpha helices and antiparallel beta sheets arranged in 2 layers, in a beta-alpha-beta-alpha-beta motif  .. 
+PF09182 Bacterial purine repressor, N-terminal<br>
+PF09183 Domain of unknown function (DUF1947)<br>Members of this family are found in a set of hypothetical Archaeal proteins. Their exact function has not, as yet, been defined.. 
+PF09184 PPP4R2<br>PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex.  It has been shown to confer resistance to the anticancer drug cisplatin in yeast  , and may confer resistance in higher eukaryotes.. 
+PF09185 Domain of unknown function (DUF1948)<br>Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with one central alpha-helix surrounded by five others, in a NusB-like fold. Their function has not, as yet, been determined  .. 
+PF09186 Domain of unknown function (DUF1949)<br>Members of this family pertain to a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement  .. 
+PF09187 Domain of unknown function(DUF1950)<br>Members of this family pertain to a set of functionally uncharacterised hypothetical eukaryotic proteins  .. 
+PF09188 Domain of unknown function (DUF1951)<br>Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with a buried central helix. Their function has not, as yet, been determined.. 
+PF09189 Domain of unknown function (DUF1952)<br>Members of this family are found in various Thermus thermophilus proteins. Their exact function has not, as yet, been determined.. 
+PF09190 DALR domain<br>This DALR domain is found in cysteinyl-tRNA-synthetases  .. 
+PF09191 CD4, extracellular<br>Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens  .. 
+PF09192 Actin-fragmin kinase, catalytic<br>Members of this family assume a secondary structure consisting of eight beta strands and 11 alpha-helices, organised in two lobes. They are predominantly found in actin-fragmin kinase, where they act as a catalytic domain that mediates the phosphorylation of actin  .. 
+PF09193 Cholecystokinin A receptor, N-terminal<br>Members of this family are found in the extracellular region of the cholecystokinin A receptor, where they adopt a tertiary structure consisting of a few helical turns and a disulphide-crosslinked loop. They are required for interaction of the cholecystokinin A receptor with it's corresponding hormonal ligand  .. 
+PF09194 Restriction endonuclease BsobI<br>Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence CYCGRG (where Y = T/C, and R = A/G) and cleave after C-1. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates  .. 
+PF09195 Restriction endonuclease BglII<br>Members of this family are predominantly found in prokaryotic restriction endonuclease BglII, and adopt a structure consisting of an alpha/beta core containing a six-stranded beta-sheet surrounded by five alpha-helices, two of which are involved in homodimerisation of the endonuclease. They recognise the double-stranded DNA sequence AGATCT and cleave after A-1, resulting in specific double-stranded fragments with terminal 5'-phosphates  .. 
+PF09196 Domain of unknown function (DUF1953)<br>This domain is found in the Archaeal protein maltooligosyl trehalose synthase produced by Sulfolobus spp. Its function has not, as yet, been defined.. 
+PF09197 Rap1, DNA-binding<br>Members of this family, which are predominantly found in the yeast protein rap1, assume a secondary structure consisting of a three-helix bundle and an N-terminal arm. They contain an Arg-Asp-Arg-Lys sequence that interacts with an ACACC region in the 3' region of the DNA-binding site  .. 
+PF09198 Bacteriophage T4 beta-glucosyltransferase<br>Members of this family are DNA-modifying enzymes encoded by bacteriophage T4 that transfer glucose from uridine diphosphoglucose to 5-hydroxymethyl cytosine bases of phage T4 DNA  .. 
+PF09199 Domain of unknown function (DUF1954)<br>Members of this family are found in various staphylococcal toxins, and adopt an OB fold, wherein the domain folds into a five-stranded beta-barrel. The exact manner in which they confer pathogenic properties to the protein has not, as yet, been determined  .. 
+PF09200 Monellin<br>Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs against a coiled antiparallel beta-sheet  .. 
+PF09201 SRX<br>Members of this family, which are predominantly found in eukaryotic signal recognition particle receptor alpha, consist of a central six-stranded anti-parallel beta-sheet sandwiched by helix alpha1 on one side and helices alpha2-alpha4 on the other. They interact with the small GTPase SR-beta, forming a complex that matches a class of small G protein-effector complexes, including Rap-Raf, Ras-PI3K(gamma), Ras-RalGDS, and Arl2-PDE(delta)  .. 
+PF09202 Rio2, N-terminal<br>Members of this family are found in Rio2, and are structurally homologous to the winged helix (wHTH) domain. They adopt a structure consisting of four alpha helices followed by two beta strands and a fifth alpha helix. The domain confers DNA binding properties to the protein, as per other winged helix domains  .. 
+PF09203 MspA<br>MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel  .. 
+PF09204 ColicinD;<br>Bacterial self-protective colicin-like immunity. Colicin D, which is synthesised by various prokaryotes, adopts an antiparallel four helical bundle fold: the helices are tightly packed, forming a compact cylindrical molecule. The protein specifically cleaves the anticodon loop of all four tRNA-Arg isoacceptors, thereby inactivating prokaryotic protein synthesis and leading to cell death  . This family also contains immunity proteins to klebicins and microcins. Many bacteria produce proteins that destroy their competitors. Colicin D is one such. The immunity proteins are expressed on the same operon as their cognate bacteriocins and protect the expressing bacterium from the effects of its own bacteriocin  .. 
+PF09205 Domain of unknown function (DUF1955)<br>Members of this family are found in hypothetical proteins synthesised by the Archaeal organism Sulfolobus. Their exact function has not, as yet, been determined.. 
+PF09206 Alpha-L-arabinofuranosidase B, catalytic<br>Members of this family, which are present in fungal alpha-L-arabinofuranosidase B, adopt a beta-sandwich fold similar to that of Concanavalin A-like lectins/glucanase. The beta-sandwich fold consists of two anti-parallel beta-sheets with seven and and six strands, respectively. In addition, there are four helices outside of the beta-strands. The beta-sandwich strands are closely packed and curved with a jelly roll topology, creating a small catalytic pocket. The domain catalyses the hydrolysis of alpha-1,2-, alpha-1,3- and alpha-1,5-L-arabinofuranosidic bonds in L-arabinose-containing hemicelluloses such as arabinoxylan and L-arabinan  .. 
+PF09207 Yeast killer toxin<br>Members of this family, which are produced by Williopsis fungi, adopt a secondary structure consisting of eight strands in two beta sheets, in a Greek-key topology  .. 
+PF09208 Restriction endonuclease MspI <br>Members of this family of prokaryotic restriction endonucleases recognise the palindromic tetranucleotide sequence 5'-CCGG and cleave between the first and second nucleotides, leaving 2 base 5' overhangs. They fold into an alpha/beta architecture, with a five-stranded mixed beta-sheet sandwiched on both sides by alpha-helices  .. 
+PF09209 Domain of unknown function (DUF1956)<br>Members of this family are found in various prokaryotic transcriptional regulator proteins. Their exact function has not, as yet, been identified.. 
+PF09210 Domain of unknown function (DUF1957)<br>This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been defined.. 
+PF09211 Domain of unknown function (DUF1958)<br>Members of this functionally uncharacterised family are found in prokaryotic penicillin-binding protein 4.. 
+PF09212 Carbohydrate binding module 27<br>Members of this family are carbohydrate binding modules that bind to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. They adopt a beta sandwich structure comprising 13 beta strands with a single, small alpha-helix and a single metal atom  .. 
+PF09213 M3<br>Members of this family of viral chemokine binding proteins adopt a structure consisting of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds. They bind with the CC-chemokine MCP-1, acting as cytokine decoy receptors  .. 
+PF09214 Bacteriophage Prd1, adsorption protein P2<br>Members of this family form a set of bacteriophage adsorption proteins, composed mainly of beta-strands whose complicated topology forms an elongated seahorse-shaped molecule with a distinct head, containing a pseudo-beta propeller structure with approximate 6-fold symmetry, and tail. They are required for the attachment of the phage to the host conjugative DNA transfer complex. This is a poorly understood large transmembrane complex of unknown architecture, with at least 11 different proteins  .. 
+PF09215 Bacteriophage T4, Gp8<br>Members of this family of viral baseplate structural proteins adopt a structure consisting of a three-layer beta-sandwich with two finger-like loops containing an alpha-helix at the opposite sides of the sandwich. The two peripheral, five-stranded, antiparallel beta-sheets are stacked against the middle, four-stranded, antiparallel beta-sheet. Attachment of this family of proteins to the baseplate during assembly creates a binding site for subsequent attachment of Gp6  .. 
+PF09216 Pfg27<br>Members of this family are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding  .. 
+PF09217 Restriction endonuclease EcoRII, N-terminal<br>The N-terminal effector-binding domain of the Restriction Endonuclease EcoRII has a DNA recognition fold, allowing for binding to 5'-CCWGG sequences. It assumes a structure composed of an eight-stranded beta-sheet with the strands in the order of b2, b5, b4, b3, b7, b6, b1 and b8. They are mostly antiparallel to each other except that b3 is parallel to b7. Alternatively, it may also be viewed as consisting of two mini beta-sheets of four antiparallel beta-strands, sheet I from beta-strands b2, b5, b4, b3 and sheet II from strands b7, b6, b1, b8, folded into an open mixed beta-barrel with a novel topology. Sheet I has a simple Greek key motif while sheet II does not  .. 
+PF09218 Domain of unknown function (DUF1959)<br>This domain is found in a set of uncharacterised Archaeal hypothetical proteins. Its function has not, as yet, been described.. 
+PF09220 L-A virus, major coat protein<br>Members of this family form the major coat protein of the Saccharomyces cerevisiae L-A virus  .. 
+PF09221 Bacterioc_AS-48;<br>Bacteriocin class IId cyclical uberolysin-like. Sammut SJ, Coggill P, Eberhardt R. Members of this family are membrane-interacting peptides, produced by Firmicutes that display a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. They adopt a helical structure, with four or five alpha helices forming a Saposin-like fold [2,5].  The structure has been found to be cyclical [1, 3, 5]. It should be pointed out that one reference   implies that both circularin A and gassericin A are class V or IIc-type bacteriocins; however we find that these two proteins fall into different Pfam families families, this one and BacteriocIIc_cy, Pfam:PF12173.. 
+PF09222 Fimbrial adhesin F17-AG, lectin domain<br>Members of this family are carbohydrate-specific lectin domains found in bacterial fimbrial adhesins. They adopt a compact, elongated structure consisting of a beta-sandwich with two major sheets: one consisting of five long strands in mixed orientations, and a front sheet with four antiparallel strands, forming an immunoglobin-like fold  .. 
+PF09223 YodA lipocalin-like domain<br>Members of this family of prokaryotic domains have been identified as part of the response of bacteria to a challenge with the toxic heavy metal cadmium. They are able to bind to cadmium, and ensure its subsequent elimination  .. 
+PF09224 Domain of unknown function (DUF1961)<br>Members of this family are found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been determined.. 
+PF09225 Restriction endonuclease PvuII<br>Members of this family are predominantly found in prokaryotic restriction endonuclease PvuII. They recognise the double-stranded DNA sequence 5'-CAGCTG-3' and cleave after G-3, resulting in specific double-stranded fragments with terminal 5'-phosphates  .. 
+PF09226 Restriction endonuclease HincII<br>Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence 5'-GTYRAC-3' and cleave after Y-3. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates  .. 
+PF09227 Domain of unknown function (DUF1962)<br>Members of this family of fungal domains are functionally uncharacterised  .. 
+PF09228 Prokaryotic Transcriptional repressor TraM<br>Members of this family of transcriptional repressors adopt a T-shaped structure, with a core composed of two antiparallel alpha-helices. These proteins can be divided into two parts, a 'globular head' and an 'elongated tail', and they negatively regulate conjugation and the expression of tra genes by antagonising traR/AAI-dependent activation  .. 
+PF09229 Activator of Hsp90 ATPase, N-terminal<br>Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity  .. 
+PF09230 DNA fragmentation factor 40 kDa<br>Members of this family of eukaryotic apoptotic proteins induce DNA fragmentation and chromatin condensation during apoptosis  .. 
+PF09231 Rice dwarf virus p3<br>Members of this family are core structural proteins found in the double-stranded RNA virus Phytoreovirus. They are large proteins without apparent domain division, with a number of all-alpha regions and one all beta domain near the C-terminal end  .. 
+PF09232 Caenorhabditis elegans Her-1<br>Her-1 adopts an all-helical structure with two subdomains: residues 19-80 comprise a left-handed three-helix bundle with an overhand connection between the second and third helices, whilst residues 81-164 comprise a left-handed anti-parallel four-helix bundle in which the first helix consists of four consecutive turns of 3-10-helix. Fourteen Cys are conserved in all known HER-1 sequences and form seven disulfide bonds. The protein dictates male development in Caenorhabditis elegans, probably by playing a direct role in cell signaling during C. elegans sex determination. It also inhibits the function of tra-2a  .. 
+PF09233 Restriction endonuclease EcoRV<br>Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence 5'-GATATC-3' and cleave after T-3. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates  .. 
+PF09234 Domain of unknown function (DUF1963)<br>This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.. 
+PF09235 Ste50p, sterile alpha motif<br>The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerisation and heterodimerisation (and in some cases oligomerisation) of the protein  .. 
+PF09236 Alpha-haemoglobin stabilising protein<br>Alpha-haemoglobin stabilising protein (AHSP) acts a molecular chaperone for free alpha-haemoglobin, preventing the harmful aggregation of alpha-haemoglobin during normal erythroid cell development: it specifically protects free alpha-haemoglobin from precipitation. AHSP adopts a helical secondary structure consisting of an elongated antiparallel three alpha-helix bundle  .. 
+PF09237 GAGA factor<br>Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence  .. 
+PF09238 Interleukin-4 receptor alpha chain, N-terminal<br>Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response  .. 
+PF09239 Topoisomerase VI B subunit, transducer<br>Members of this family adopt a structure consisting of a four-stranded beta-sheet backed by three alpha-helices, the last of which is over 50 amino acids long and extends from the body of the protein by several turns. This domain has been proposed to mediate intersubunit communication by structurally transducing signals from the ATP binding and hydrolysis domains to the DNA binding and cleavage domains of the gyrase holoenzyme  .. 
+PF09240 Interleukin-6 receptor alpha chain, binding<br>Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6  .. 
+PF09241 Herpesviridae viral cyclin<br>Members of this family of viral cyclins adopt a helical structure consisting of five alpha-helices, with one helix surrounded by the others. They specifically activate CDK6 of host cells to a very high degree  .. 
+PF09242 Flavocytochrome c sulphide dehydrogenase, flavin-binding<br>Members of this family adopt a structure consisting of a beta(3,4)-alpha(3) core, and an alpha+beta sandwich. They are required for binding to flavin, and subsequent electron transfer  .. 
+PF09243 Mitochondrial small ribosomal subunit Rsm22<br>Pfam-B_8789 (release 20.0). Rsm22 has been identified as a mitochondrial small ribosomal subunit   and is a methyltransferase.  In Schizosaccharomyces pombe, Rsm22 is tandemly fused to Cox11 (a factor required for copper insertion into cytochrome oxidase) and the two proteins are proteolytically cleaved after import into the mitochondria  .. 
+PF09244 Domain of unknown function (DUF1964)<br>Members of this family of bacterial domains adopt a beta-sandwich fold, with Greek-key topology. They are C-terminal to the catalytic sucrose phosphorylase beta/alpha barrel domain, and are functionally uncharacterised  .. 
+PF09245 Mycoplasma arthritidis-derived mitogen<br>Mycoplasma arthritidis-derived mitogen (MA-Mit) adopts a completely alpha-helical structure consisting of ten alpha helices. It is a superantigen that can activate large fractions of T cells bearing particular TCR V-beta elements. Two MA-Mit molecules form an asymmetric dimer and cross-link two MHC antigens to form a dimerised MA-Mit-MHC complex  .. 
+PF09246 PHAT<br>The PHAT (pseudo-HEAT analogous topology) domain assumes a structure consisting of a layer of three parallel helices packed against a layer of two antiparallel helices, into a cylindrical shaped five-helix bundle. It is found in the RNA-binding protein Smaug, where it is essential for high-affinity RNA binding  .. 
+PF09247 TATA box-binding protein binding<br>Members of this family adopt a structure consisting of three alpha helices and a beta-hairpin. They bind to TATA box-binding protein (TBP), inhibiting TBP interaction with the TATA element, thereby resulting in shutting down of gene transcription  .. 
+PF09248 Domain of unknown function (DUF1965)<br>Members of this family of fungal domains adopt a structure that consists of an alpha/beta motif. Their exact function has not, as yet, been determined  .. 
+PF09249 tRNA nucleotidyltransferase, second domain<br>Members of this family adopt a structure consisting of a five helical bundle core. They are predominantly found in Archaeal tRNA nucleotidyltransferase, following the catalytic nucleotidyltransferase domain  .. 
+PF09250 Bifunctional DNA primase/polymerase, N-terminal<br>Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities  .. 
+PF09251 Salmonella phage P22 tail-spike<br>Members of this family of viral domains adopt a structure consisting of a single-stranded right-handed beta-helix, which in turn is made of parallel beta-strands and short turns. They are required for recognition of the 0-antigenic repeating units of the cell surface, and for subsequent infection of the bacterial cell  .. 
+PF09252 Allergen Fel d I-B chain<br>Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide  .. 
+PF09253 Pollen allergen ole e 6<br>Members of this family consist of two nearly antiparallel alpha-helices, that are connected by a short loop and followed by a long, unstructured C-terminal tail. They are highly allergenic, primarily mediating olive allergy  .. 
+PF09254 Restriction endonuclease FokI, C terminal<br>Members of this family are predominantly found in prokaryotic restriction endonuclease FokI, and adopt a structure consisting of an alpha/beta/alpha core containing a five-stranded beta-sheet. They recognise the double-stranded DNA sequence 5'-GGATG-3' and cleave DNA phosphodiester groups 9 base pairs away on this strand and 13 base pairs away on the complementary strand  .. 
+PF09255 Caf1 Capsule antigen<br>Members of this family are predominantly found in the F1 capsule antigen Caf1 synthesised by Yersinia bacteria. They adopt a structure consisting of a seven strands arranged in two beta-sheets, in a Greek-key topology, and mediate targeting of the bacterium to sites of infection  .. 
+PF09256 BAFF-R, TALL-1 binding<br>Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 13c, BAFF-R, are required for binding to tumour necrosis factor ligand TALL-1  .. 
+PF09257 BCMA, TALL-1 binding<br>Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 17, BCMA, are required for binding to tumour necrosis factor ligand TALL-1  .. 
+PF09258 EXTL2; <br>Glycosyl transferase family 64 domain. Members of this family catalyse the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate  .. 
+PF09259 Fungal immunomodulatory protein Fve<br>Fve is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like beta-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions  .. 
+PF09260 Domain of unknown function (DUF1966)<br>This domain is found in various fungal alpha-amylase proteins. Its exact function has not, as yet, been defined  .. 
+PF09261 Alpha mannosidase, middle domain<br>Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase  .. 
+PF09262 Peroxisome biogenesis factor 1, N-terminal <br>Members of this family adopt a double psi beta-barrel fold, similar in structure to the Cdc48 N-terminal domain. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation  .. 
+PF09263 Peroxisome biogenesis factor 1, N-terminal <br>Members of this family adopt a Cdc48 domain 2-like fold, with a beta-alpha-beta(3) arrangement. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation  .. 
+PF09264 Vibrio cholerae sialidase, lectin insertion<br>Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme  .. 
+PF09265 Cytokinin dehydrogenase 1, FAD and cytokinin binding<br>Members of this family adopt an alpha+beta sandwich structure with an antiparallel beta-sheet, in a ferredoxin-like fold. They are predominantly found in plant cytokinin dehydrogenase 1, where they are capable of binding both FAD and cytokinin substrates. The substrate displays a 'plug-into-socket' binding mode that seals the catalytic site and precisely positions the carbon atom undergoing oxidation in close contact with the reactive locus of the flavin  .. 
+PF09266 Viral DNA topoisomerase I, N-terminal<br>Members of this family are predominantly found in viral DNA topoisomerase, and assume a beta(2)-alpha-beta-alpha-beta(2) fold, with a left-handed crossover between strands beta2 and beta3  .. 
+PF09267 Dictyostelium STAT, coiled coil<br>Members of this family are found in Dictyostelium STAT proteins and adopt a structure consisting of four long alpha-helices, folded into a coiled coil. They are responsible for nuclear export of the protein  .. 
+PF09268 Clathrin, heavy-chain linker<br>Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain  .. 
+PF09269 Domain of unknown function (DUF1967)<br>Members of this family contain a four-stranded beta sheet and three alpha helices flanked by an additional beta strand. They are predominantly found in the bacterial GTP-binding protein Obg, and are still functionally uncharacterised  .. 
+PF09270 Beta-trefoil;<br>Beta-trefoil DNA-binding domain. Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR)  .. 
+PF09271 LAG1, DNA binding<br>Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding  .  This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.. 
+PF09272 Hepsin, SRCR<br>Members of this family form an extracellular domain of the serine protease hepsin. They are formed primarily by three elements of regular secondary structure: a 12-residue alpha helix, a twisted five-stranded antiparallel beta sheet, and a second, two-stranded, antiparallel sheet. The two beta-sheets lie at roughly right angles to each other, with the helix nestled between the two, adopting an SRCR fold. The exact function of this domain has not been identified, though it probably may serve to orient the protease domain or place it in the vicinity of its substrate  .. 
+PF09273 Rubisco LSMT substrate-binding<br>Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex  .. 
+PF09274 ParG<br>Members of this family of plasmid partition proteins adopt a ribbon-helix-helix fold, with a core of four alpha-helices. They are an essential component of the DNA partition complex of the multidrug resistance plasmid TP228  .. 
+PF09275 Pertussis toxin S4 subunit<br>Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology  .. 
+PF09276 Pertussis toxin S5 subunit <br>Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology  .. 
+PF09277 Erythronolide synthase, docking<br>Members of this family of docking domains are found in prokaryotic erythronolide synthase. They adopt a structure consisting of a bundle of four alpha-helices, and mediate homodimerisation of the protein, stabilising the resulting complex  .. 
+PF09278 MerR, DNA binding<br>Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold  .. 
+PF09279 efhand_like;<br>Phosphoinositide-specific phospholipase C, efhand-like. Members of this family are predominantly found in phosphoinositide-specific phospholipase C. They adopt a structure consisting of a core of four alpha helices, in an EF like fold, and are required for functioning of the enzyme  .. 
+PF09280 XPC-binding domain<br>Members of this family adopt a structure consisting of four alpha helices, arranged in an array. They bind specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair  .. 
+PF09281 Taq polymerase, exonuclease<br>Members of this family are found in prokaryotic Taq DNA polymerase, where they assume a ribonuclease H-like motif. The domain confers 5'-3' exonuclease activity to the polymerase  .. 
+PF09282 Mago binding<br>Members of this family adopt a structure consisting of a small globular all-beta-domain, with a three-stranded beta-sheet and a contiguous beta-hairpin. They bind to Mago alpha-helices via extensive electrostatic interactions and at a beta2-beta3 loop via hydrophobic interactions  .. 
+PF09284 Rhamnogalacturonase B, N-terminal<br>Members of this family are found in prokaryotic Rhamnogalacturonase B, and adopt a structure consisting of a beta supersandwich, with eighteen strands in two beta-sheets. The exact function of the domain is unknown, but a putative role includes carbohydrate-binding  .. 
+PF09285 Elongation factor P, C-terminal<br>Members of this family of nucleic acid binding domains are predominantly found in elongation factor P, where they adopt an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology  .. 
+PF09286 Pro-kumamolisin, activation domain <br>Members of this family are found in various subtilase propeptides, and adopt a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptide  .. 
+PF09287 CEP-1, DNA binding<br>Members of this family of DNA-binding domains are found the transcription factor CEP-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology  .. 
+PF09288 Fungal ubiquitin-associated domain <br>Members of this family of ubiquitin binding domains adopt a structure consisting of a three alpha-helix bundle. They are predominantly found in fungal ubiquitin-protein ligases  .. 
+PF09289 Follistatin/Osteonectin-like EGF domain<br>Members of this family are predominantly found in osteonectin and follistatin and adopt an EGF-like fold [1,2].. 
+PF09290 Prokaryotic acetaldehyde dehydrogenase, dimerisation<br>Members of this family are found in prokaryotic acetaldehyde dehydrogenase (acylating), and adopt a structure consisting of an alpha-beta-alpha-beta(3) core. They mediate dimerisation of the protein  .. 
+PF09291 Domain of unknown function (DUF1968)<br>Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.. 
+PF09292 Endonuclease VIII-like 1, DNA bind<br>Members of this family are predominantly found in Endonuclease VIII-like 1 and adopt a glucocorticoid receptor-like fold. They allow for DNA binding  .. 
+PF09293 T4 RNase H, C terminal<br>Members of this family are found in T4 RNaseH ribonuclease, and adopt a SAM domain-like fold, consisting of a bundle of four/five helices. These residues may have a role in providing a docking site for other proteins or enzymes in the replication fork  .. 
+PF09294 Interferon-alpha/beta receptor, fibronectin type III<br>Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha  .. 
+PF09295 ChAPs (Chs5p-Arf1p-binding proteins)<br>Pfam-B_11349 (release 19.0). ChAPs (Chs5p-Arf1p-binding proteins) are required for the export of specialised cargo from the Golgi.\.  They physically interact with Chs3, Chs5 and the small GTPase Arf1, and they form also interactions with each other  .. 
+PF09296 NADH pyrophosphatase-like rudimentary NUDIX domain<br>The N-terminal domain in NADH pyrophosphatase, which has a rudiment Nudix fold according to SCOP.. 
+PF09297 NADH pyrophosphatase zinc ribbon domain<br>This domain is found in between two duplicated NUDIX domains. It has a zinc ribbon structure.. 
+PF09298 DUF1969;<br>Fumarylacetoacetase N-terminal. Sammut SJ, Eberhardt R. The N-terminal domain of fumarylacetoacetate hydrolase is functionally uncharacterised, and adopts a structure consisting of an SH3-like barrel  .. 
+PF09299 Mu transposase, C-terminal<br>Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology  .. 
+PF09300 Tectiviridae, minor capsid<br>Members of this family form the minor capsid protein of various Tectiviridae  .. 
+PF09301 Domain of unknown function (DUF1970)<br>Members of this family consist of various uncharacterised viral hypothetical proteins.. 
+PF09302 XLF (XRCC4-like factor)<br>Mistry J, Wood V, Hentges P, Doherty A. XLF (also called Cernunnos) interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining.  It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated downregulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining  .  This family contains Nej1 (non-homologous end-joining factor)  , and Lif1  .. 
+PF09303 KCNMB2, ball and chain domain<br>Members of this family are found in the cytoplasmic N-terminus of KCNMB2, the beta-2 subunit of large conductance calcium and voltage-activated potassium channels. They are responsible for the fast inactivation of these channels  .. 
+PF09304 Cortexillin I, coiled coil<br>Members of this family are predominantly found in the actin-bundling protein Cortexillin I from Dictyostelium discoideum. They adopt a structure consisting of an 18-heptad-repeat alpha-helical coiled-coil, and are a prerequisite for the assembly of Cortexillin I  .. 
+PF09305 TACI, cysteine-rich domain<br>Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF  .. 
+PF09306 Bacteriophage, scaffolding protein<br>Members of this family of scaffolding proteins are produced by various bacteriophages  .. 
+PF09307 CLIP, MHC2 interacting<br>Members of this family are found in class II invariant chain-associated peptide (CLIP), and are required for association with class II major histocompatibility complex (MHC) in the MHC class II processing pathway  .. 
+PF09308 LuxQ, periplasmic<br>Members of this family constitute the periplasmic sensor domain of the prokaryotic protein LuxQ, and assume a structure consisting of two tandem Per/ARNT/Simple-minded (PAS) folds  .. 
+PF09309 FCP1, C-terminal<br>The C-terminal domain of FCP-1 is required for interaction with the carboxy terminal domain of RAP74. Interaction relies extensively on van der Waals contacts between hydrophobic residues situated within alpha-helices in both domains  .. 
+PF09310 POU domain, class 2, associating factor 1<br>Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres  .. 
+PF09311 Rabaptin-like protein<br>Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes  .. 
+PF09312 SurA N-terminal domain<br>This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.. 
+PF09313 Domain of unknown function (DUF1971)<br>Pfam-B_3000 (release 20.0). Members of this family of functionally uncharacterised domains are predominantly found in bacterial Tellurite resistance protein.. 
+PF09314 Domain of unknown function (DUF1972)<br>Pfam-B_3020 (release 20.0). Members of this family of functionally uncharacterised domains are found in bacterial glycosyltransferases and rhamnosyltransferases.. 
+PF09315 Domain of unknown function (DUF1973)<br>Pfam-B_3022 (release 20.0). Members of his family of functionally uncharacterised domains are found in various eukaryotic calcium-dependent chloride channels.. 
+PF09316 C-myb, C-terminal<br>Pfam-B_3027 (release 20.0). Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis  .. 
+PF09317 Domain of unknown function (DUF1974)<br>Pfam-B_3029 (release 20.0). Members of this family of functionally uncharacterised domains are predominantly found in various prokaryotic acyl-coenzyme a dehydrogenases. . 
+PF09318 Domain of unknown function (DUF1975)<br>Pfam-B_3057 (release 20.0). Members of this family of functionally uncharacterised domains are predominantly found in the N-terminal region of various prokaryotic alpha-glucosyltransferases.. 
+PF09320 Domain of unknown function (DUF1977)<br>Pfam-B_3043 (release 20.0). Members of this family of functionally uncharacterised domains are predominantly found in dnaj-like proteins.. 
+PF09321 Domain of unknown function (DUF1978)<br>Pfam-B_3044 (release 20.0). Members of this family are found in various hypothetical proteins produced by the bacterium Chlamydia pneumoniae. Their exact function has not, as yet, been identified.. 
+PF09322 Domain of unknown function (DUF1979)<br>Pfam-B_3053 (release 20.0). Members of this family of functionally uncharacterised domains are found in various Oryza sativa mutator-like transposases.. 
+PF09323 Domain of unknown function (DUF1980)<br>Pfam-B_3062 (release 20.0). Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined.. 
+PF09324 Domain of unknown function (DUF1981)<br>Pfam-B_3041 (release 20.0). Members of this family of functionally uncharacterised domains are found in various plant and yeast protein transport proteins.. 
+PF09325 Vps5 C terminal like<br>Pfam-B_6206 (release 20.0). Vps5 is a sorting nexin that functions in membrane trafficking. This is the C terminal dimerisation domain  .. 
+PF09326 Domain of unknown function (DUF1982)<br>Pfam-B_3077 (release 20.0). Members of this family of functionally uncharacterised domains are found in the C-terminal region of various prokaryotic NADH dehydrogenases.. 
+PF09327 Domain of unknown function (DUF1983)<br>Pfam-B_3073 (release 20.0). Members of this family of functionally uncharacterised domains are found in various bacteriophage host specificity proteins.. 
+PF09328 DUF1984; <br>Domain of unknown function (DUF1984). Pfam-B_3070 (release 20.0). Members of this family of functionally uncharacterised domains are found at the C-terminus of plant phytochelatin synthases.. 
+PF09329 Primase zinc finger<br>Pfam-B_9710 (release 20.0). This zinc finger is found in yeast Mcm10 proteins and DnaG-type primases  .. 
+PF09330 D-lactate dehydrogenase, membrane binding<br>Members of this family are predominantly found in prokaryotic D-lactate dehydrogenase, forming the cap-membrane-binding domain, which consists of a large seven-stranded antiparallel beta-sheet flanked on both sides by alpha-helices. They allow for membrane association  .. 
+PF09331 Domain of unknown function (DUF1985)<br>Pfam-B_3094 (release 20.0). Members of this family of functionally uncharacterised domains are found in a set of Arabidopsis thaliana hypothetical proteins.. 
+PF09332 Mcm10 replication factor<br>Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha  .. 
+PF09333 ATG C terminal domain<br>Pfam-B_61662 (release 20.0). ATG2 (also known as Apg2) is a peripheral membrane protein.  It functions in both cytoplasm to vacuole targeting and autophagy  .. 
+PF09334 tRNA synthetases class I (M)<br>Pfam-B_107 (release 20.0). This family includes methionyl tRNA synthetases.. 
+PF09335 SNARE associated Golgi protein<br>This is a family of SNARE associated Golgi proteins.  The yeast member of this family (Swiss:P36164) localises with the t-SNARE Tlg2  .. 
+PF09336 Vps4 C terminal oligomerisation domain<br>Pfam-B_8681 (release 20.0). This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerisation  .. 
+PF09337 His(2)-Cys(2) zinc finger<br>This domain binds to histone upstream activating sequence (UAS) elements that are found in histone gene promoters  .. 
+PF09338 Glycine/sarcosine/betaine reductase component B subunits<br>Pfam-B_25756 (release 20.0). This is a family of glycine reductase, sarcosine reductase and betaine reductases.  These enzymes catalyse the following reactions.  sarcosine reductase: Acetyl phosphate + methylamine + thioredoxin disulphide = N-methylglycine + phosphate + thioredoxin Acetyl phosphate + NH(3) + thioredoxin disulphide = glycine + phosphate + thioredoxin. betaine reductase: Acetyl phosphate + trimethylamine + thioredoxin disulphide = N,N,N-trimethylglycine + phosphate + thioredoxin  .. 
+PF09339 IclR helix-turn-helix domain<br>Pfam-B_70 (release 18.0). 
+PF09340 Histone acetyltransferase subunit NuA4<br>Pfam-B_29415 (release 20.0). The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast  .  NuA4 complexes are highly conserved in eukaryotes and play primary roles in transcription, cellular response to DNA damage, and cell cycle control  .. 
+PF09341 Transcription factor Pcc1<br>Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth  .. 
+PF09342 Domain of unknown function (DUF1986)<br>Mistry J, Rawlings ND. Pfam-B_99782 (release 20.0). This domain is found in serine proteases and is predicted to contain disulphide bonds (see Swiss:P98159).. 
+PF09343 CHP2217;<br>Conserved hypothetical protein 2217 (DUF2460). This model represents a family of conserved hypothetical proteins. It is usually (but not always) found in apparent phage-derived regions of bacterial chromosomes.. 
+PF09344 CT1975-like protein<br>CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.. 
+PF09345 Domain of unknown function (DUF1987)<br>This family of proteins are functionally uncharacterised.. 
+PF09346 DUF1988; <br>SMI1 / KNR4 family (SUKH-1). Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation   . Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems  . . 
+PF09347 Domain of unknown function (DUF1989)<br>This family of proteins are functionally uncharacterised.. 
+PF09348 Domain of unknown function (DUF1990)<br>This family of proteins are functionally uncharacterised.. 
+PF09349 DUF1991; <br>The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin  . This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576).. 
+PF09350 Domain of unknown function (DUF1992)<br>This family of proteins are functionally uncharacterised.. 
+PF09351 Domain of unknown function (DUF1993)<br>This family of proteins are functionally uncharacterised.. 
+PF09353 Domain of unknown function (DUF1995)<br>This family of proteins are functionally uncharacterised.. 
+PF09354 HNF3 C-terminal domain<br>This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterised by the FxIxxIL sequence  .. 
+PF09355 Phage protein Gp19/Gp15/Gp42<br>This family of proteins are functionally uncharacterised. They are found in a variety of bacteriophage.. 
+PF09356 Phage conserved hypothetical protein BR0599<br>This entry describes a family of proteins found almost exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. An apparent exception is Wolbachia pipientis wMel, a bacterial endosymbiont of the fruit fly, which has several candidate phage-related genes physically separate from obvious prophage regions.. 
+PF09357 RteC protein<br>Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer  .. 
+PF09358 Ubiquitin-activating enzyme e1 C-terminal domain<br>This presumed domain found at the C-terminus of Ubiquitin-activating enzyme e1 proteins is functionally uncharacterised.. 
+PF09359 VTC domain<br>This presumed domain is found in the yeast vacuolar transport chaperone proteins VTC2, VTC3 and VTC4. This domain is also found in a variety of bacterial proteins.. 
+PF09360 Iron-binding zinc finger CDGSH type<br>The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family  . The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, Pfam:PF10660  . The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm  .. 
+PF09361 Phasin protein<br>This entry describes a group of small proteins found associated with inclusions in bacterial cells. Most associate with polyhydroxyalkanoate (PHA) inclusions, the most common of which consist of polyhydroxybutyrate (PHB). These are designated granule-associate proteins or phasins.. 
+PF09362 Domain of unknown function (DUF1996)<br>This family of proteins are functionally uncharacterised.. 
+PF09363 XFP C-terminal domain<br>Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22  .. 
+PF09364 XFP N-terminal domain<br>Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22  . This family is distantly related to transketolases e.g. Pfam:PF02779.. 
+PF09365 CHP02453; <br>Conserved hypothetical protein (DUF2461). Members of this family are widely (though sparsely) distributed bacterial proteins, about 230 residues in length. All members have a motif RxxRDxRFxxx[DN]KxxY. The function of this protein family is unknown.. 
+PF09366 Protein of unknown function (DUF1997)<br>This family of proteins are functionally uncharacterised.. 
+PF09367 CpeS-like protein<br>This family, that includes CpeS proteins, is functionally uncharacterised.. 
+PF09368 Sas10_Utp3_C;<br>Sas10 C-terminal domain. Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.. 
+PF09369 Domain of unknown function (DUF1998)<br>This family of proteins are functionally uncharacterised. They are mainly found in helicase proteins so could be RNA binding. This family includes a probable zinc binding motif at its C-terminus.. 
+PF09370 TIM-barrel signal transduction protein<br>This domain is likely to have a TIM barrel fold related to IGPS. Although this family of proteins are functionally uncharacterised this domain is found as an N-terminal domain of sigma 54 -dependent transcriptional activators (enhancer-binding proteins) suggesting a potential role in signal recognition/receiving and signal transduction.. 
+PF09371 Tex-like protein N-terminal domain<br>This presumed domain is found at the N-terminus of Swiss:Q45388. This protein defines a novel family of prokaryotic transcriptional accessory factors  .. 
+PF09372 PRANC domain<br>This presumed domain is found at the C-terminus of a variety of Pox virus proteins. The PRANC (Pox proteins Repeats of ANkyrin - C terminal) domain is also found on its own in some proteins. The function of this domain is unknown, but it appears to be related to the F-box domain and may play a similar role.. 
+PF09373 Pseudomurein-binding repeat<br>Pfam-B_12784 (Release 21.0). Methanothermobacter thermautotrophicus is a methanogenic Gram-positive microorganism with a cell wall consisting of pseudomurein. This repeat specifically binds to pseudomurein. This repeat is found at the N terminus of PeiW and PeiP which are pseudomurein binding phage proteins.. 
+PF09374 Predicted Peptidoglycan domain<br>Pfam-B_8737 (release 8.0). This family contains a potential peptidoglycan binding domain.. 
+PF09375 Imelysin<br>The imelysin peptidase was first identified in Pseudomonas aeruginosa. The active site residues have not been identified. However, His201 and Glu204 are completely conserved in the family and occur in an HXXE motif that is also found in family M14.. 
+PF09376 NurA domain<br>This family includes NurA a nuclease exhibiting both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA from the hyperthermophilic archaeon Sulfolobus acidocaldarius  .. 
+PF09377 SBDS protein C-terminal domain<br>This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.  Members of this family play a role in RNA metabolism    .. 
+PF09378 HAS barrel domain<br>The HAS barrel is named after HerA-ATP Synthase. In ATP synthases, this domain is implicated in the assembly of the catalytic toroid and docking of accessory subunits, such as the subunit of the ATP synthase complex. Similar roles in docking of the functional partner, the NurA nuclease, and assembly of the HerA toroid complex appear likely for the HAS-barrel of the HerA family  .. 
+PF09379 FERM N-terminal domain <br>This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.. 
+PF09380 FERM C-terminal PH-like domain<br>Pfam-B_851 (release 2.1). 
+PF09381 Outer membrane protein G (OmpG)<br>Porins are channel proteins in the outer membrane of gram negative bacteria which mediate the uptake of molecules required for growth and survival.  Escherichia coli OmpG forms a 14 stranded beta-barrel and in contrast to most porins, appears to function as a monomer  .  The central pore of OmpG is wider than other E. coli porins and it is speculated that it may form a non-specific channel for the transport of larger oligosaccharides  .. 
+PF09382 RQC domain<br>Pfam-B_571 (release 21.0). This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure.  The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain  .. 
+PF09383 NIL domain<br>Pfam-B_524 (release 21.0). This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins. This domain is likely to act as a substrate binding domain. The domain has been named after a conserved sequence in some members of the family.. 
+PF09384 U3_snoRNA_C;<br>Pfam-B_7112 (release 21.0). U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA  . It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs)  . This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (Pfam:PF00400).. 
+PF09385 Histidine kinase N terminal<br>This domain is found at the N terminal of sensor histidine kinase proteins.. 
+PF09386 Antitoxin ParD<br>ParD is a plasmid anti-toxin than forms a ribbon-helix-helix DNA binding structure  .  It stabilises plasmids by inhibiting ParE toxicity in cells that express ParD and ParE.  ParD forms a dimer and also regulates its own promoter (parDE).. 
+PF09387 Mitochondrial RNA binding protein MRP<br>MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex.  The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilises them in an unfolded conformation suitable for RNA-RNA hybridisation.  Each MRP subunit adopts a 'whirly' transcription factor fold  .. 
+PF09388 Spo0E like sporulation regulatory protein<br>Spore formation is an extreme response to starvation and can also be a component of disease transmission.  Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A.  Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation.  This is a family of Spo0E-like phosphatases.  The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure  .. 
+PF09390 Protein of unknown function (DUF1999)<br>This family contains a putative Fe-S binding reductase (Swiss:Q72J89) whose structure adopts an alpha and beta fold.. 
+PF09391 Protein of unknown function (DUF2000)<br>This is a family of proteins of unknown function. The structure of one of the proteins in this family has been shown to adopt an alpha beta fold.. 
+PF09392 Type III secretion needle MxiH like<br>Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens.  MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells  .  Once inside, the effector proteins subvert normal cell function to aid infection.. 
+PF09393 Protein of unknown function (DUF2001)<br>This family includes phage-like element PBSX protein (Swiss:P54332) whose structure adopts a beta barrel flanked with alpha helical regions.. 
+PF09394 Chagasin_I42;<br>Chagasin family peptidase inhibitor I42. Chagasin is a cysteine peptidase inhibitor   which forms a beta barrel structure  .. 
+PF09396 Thrombin light chain<br>Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.. 
+PF09397 Ftsk gamma domain<br>This domain directs oriented DNA translocation and forms a winged helix structure  .  Mutated proteins with substitutions in the FtsK gamma DNA-recognition helix are impaired in DNA binding  .. 
+PF09398 FOP N terminal dimerisation domain<br>Fibroblast growth factor receptor 1 (FGFR1) oncogene partner (FOP) is a centrosomal protein that is involved in anchoring microtubules to subcellular structures.  This domain includes a Lis-homology motif.  It forms an alpha helical bundle and is involved in dimerisation  .. 
+PF09399 SARS lipid binding protein<br>This is a family of proteins found in SARS coronavirus.  The protein has a novel fold which forms a dimeric tent-like beta structure with an amphipathic surface, and a central hydrophobic cavity that binds lipid molecules  . This cavity is likely to be involved in membrane attachment  .. 
+PF09400 Protein of unknown function (DUF2002)<br>This is a family of putative cytoplasmic proteins.  The structure of these proteins form an antiparallel beta and sheet and contain some alpha helical regions.. 
+PF09401 RNA synthesis protein NSP10<br>Non-structural protein 10 (NSP10) is involved in RNA synthesis. it is synthesised as a polyprotein whose cleavage generates many non-structural proteins.  NSP10 contains two zinc binding motifs and forms two anti-parallel helices which are stacked against an irregular beta sheet  .\.   A cluster of basic residues on the protein surface suggests a nucleic acid-binding function.. 
+PF09402 MAN1_C;<br>Man1-Src1p-C-terminal domain. MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation.  The C terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad  . This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands  .. 
+PF09403 Adhesion protein FadA<br>FadA (Fusobacterium adhesin A) is an adhesin which forms two alpha helices.. 
+PF09404 Eukaryotic protein of unknown function (DUF2003)<br>This is a family of proteins of unknown function which adopt an alpha helical and beta sheet structure.. 
+PF09405 CASC3/Barentsz eIF4AIII binding<br>This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz).  CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa.  The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide   .. 
+PF09406 Protein of unknown function (DUF2004)<br>This is a family of proteins with unknown function.  The structure of one of the proteins in this family has revealed a novel alpha-beta fold  .. 
+PF09407 Protein of unknown function (DUF2005)<br>This is a family of proteins with unknown function.. 
+PF09408 Spike receptor binding domain<br>Spike is an envelope glycoprotein which aids viral entry into the host cell.  This domain corresponds is the immunogenic receptor binding domain of the protein which binds to angiotensin-converting enzyme 2 (ACE2)  .. 
+PF09409 PUB domain<br>The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain  . This domain is also found on other proteins linked to the ubiquitin-proteasome system.. 
+PF09411 Lipid A 3-O-deacylase (PagL)<br>PagL is an outer membrane protein with lipid A 3-O-deacylase activity. It forms an 8 stranded beta barrel structure  .. 
+PF09412 Endoribonuclease XendoU<br>This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.. 
+PF09413 Domain of unknown function (DUF2007)<br>This is a family of proteins with unknown function.. 
+PF09414 RNA ligase<br>This is a family of RNA ligases. The enzyme repairs RNA strand breaks in nicked DNA:RNA and RNA:RNA but not in DNA:DNA duplexes.. 
+PF09415 DUF2008;<br>CENP-S associating Centromere protein X. The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.. 
+PF09416 RNA helicase (UPF2 interacting domain)<br>UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation.  This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD)  .. 
+PF09418 Protein of unknown function (DUF2009)<br>Pfam-B_18128 (release 21.0). This is a eukaryotic family of proteins with unknown function.. 
+PF09419 DUF2010;<br>Mitochondrial PGP phosphatase. Pfam-B_22310 (release 21.0). This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad  .. 
+PF09420 Ribosome biogenesis protein Nop16<br>Pfam-B_6406 (release 21.0). Nop16 is a protein involved in ribosome biogenesis.. 
+PF09421 Frequency clock protein<br>The frequency clock protein, is the central component of the frq-based circadian negative feedback loop, regulates various aspects of the circadian clock in Neurospora crassa  . This protein has been shown to interact with itself via a coiled-coil  .. 
+PF09422 WTX protein<br>The WTX protein is found to be inactivated in one third of Wilms tumours  . The WTX protein is functionally uncharacterised.. 
+PF09423 PhoD-like phosphatase<br>
+PF09424 Yqey-like protein<br>The function of this domain found in the YqeY protein is uncertain.. 
+PF09425 Divergent CCT motif<br>This short motif is found in a number of plant proteins. It appears to be related to the N-terminal half of the CCT motif. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif  .. 
+PF09426 Vacuolar R-SNARE Nyv1 N terminal<br>Pfam-B_50964 (release 21.0). This domain corresponds to the N terminal domain of vacuolar R-SNARE Nyv1 which adopts a longin fold  .  In yeast it has been shown that this domain is sufficient to direct the transport of Nyv1 to limiting membrane of the vacuole  .. 
+PF09427 SREBP_C; <br>Domain of unknown function (DUF2014) . Pfam-B_71890 (release 21.0). This domain is found at the C terminal of a family of ER membrane bound transcription factors called sterol regulatory element binding proteins (SREBP).. 
+PF09428 Fungal protein of unknown function (DUF2011)<br>This is a family of fungal proteins whose function is unknown.. 
+PF09429 WW domain binding protein 11<br>Pfam-B_13108 (release 21.0). The WW domain is a small protein module with a triple-stranded beta-sheet fold.  This is a family of WW domain binding proteins.. 
+PF09430 Protein of unknown function (DUF2012)<br>Pfam-B_49614 (release 21.0). This is a eukaryotic family of uncharacterised proteins.. 
+PF09431 Protein of unknown function (DUF2013)<br>Pfam-B_11317 (release 21.0). This region is found at the C terminal of a group of cytoskeletal proteins.. 
+PF09432 Tho complex subunit THP2<br>The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1  .. 
+PF09435 Fungal protein of unknown function (DUF2015)<br>This is a fungal family of uncharacterised proteins.. 
+PF09436 Domain of unknown function (DUF2016)<br>A predicted alpha+beta domain that is usually fused N-terminal to the JAB metallopeptidase. This protein in turn is found in conserved gene neighborhoods that include genes encoding the bacterial homologs of the ubiquitin modification system such as the E1, E2 and Ub proteins  . The domain is also known as the JAB-N domain.. 
+PF09437 Pombe specific 5TM protein<br>
+PF09438 Domain of unknown function (DUF2017)<br>Mistry J, Iyer LM, Burroughs AM, Aravind L. This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB  peptidases  .. 
+PF09439 Signal recognition particle receptor beta subunit<br>Pfam-B_7840 (release 21.0). The beta subunit of the signal recognition particle receptor (SRP) is a transmembrane GTPase which anchors the alpha subunit to the endoplasmic reticulum membrane  .. 
+PF09440 eIF3 subunit 6 N terminal domain<br>Pfam-B_4886 (release 21.0). This is the N terminal domain of subunit 6 translation initiation factor eIF3.. 
+PF09441 ARS binding protein 2<br>This DNA-binding protein binds to the autonomously replicating sequence (ARS) binding element. It may play a role in regulating the cell cycle response to stress signals  .. 
+PF09442 Domain of unknown function (DUF2018)<br>Acid-adaptive protein possibly of physiological significance when H.pylori colonises the human stomach, which adopts a unique four alpha-helical triangular conformations. The biologically active form is thought to be a tetramer. The protein is expressed along with six other proteins, some of which are related to iron storage and haem biosynthesis  .. 
+PF09443 Cripto_Frl-1_Cryptic (CFC)<br>CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours [1,2] and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2  .  CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain  .. 
+PF09444 MRC1-like domain<br>This putative domain is found to be the most conserved region in mediator of replication checkpoint protein 1.. 
+PF09445 RNA cap guanine-N2 methyltransferase<br>Pfam-B_9480 (Release 21.0). RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyse methylation of the exocyclic N2 amine of 7-methylguanosine  .. 
+PF09446 VMA21-like domain<br>This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localised in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase  .. 
+PF09447 Cnl2/NKP2 family protein<br>This family includes the Cnl2 kinetochore protein  .. 
+PF09448 Methylmuconolactone methyl-isomerase <br>MmlI is a short, approx 115 residue, protein of two alpha helices and four beta strands. It is involved in the catabolism of methyl-substituted aromatics via a modified oxo-adipate pathway in bacteria. The enzyme appears to be monomeric in some species   and tetrameric in others  . The known structure shows two copies of the protein form a dimeric alpha beta barrel.. 
+PF09449 Domain of unknown function (DUF2020)<br>Protein of unknown function found in bacteria.. 
+PF09450 Domain of unknown function (DUF2019)<br>Protein of unknown function found in bacteria.. 
+PF09451 Autophagy-related protein 27<br>
+PF09452 ESCRT-I subunit Mvb12<br>The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified  , multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23)  .. 
+PF09453 HIRA B motif<br>The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between HIRA Pfam:PF07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions  . The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus. . 
+PF09454 Vps23 core domain<br>ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (Pfam:PF03997) and Vps37. Vps23 gives ESCRT-I complex its stability  .. 
+PF09455 CRISPR-associated (Cas) DxTHG family<br>CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins.  The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.. 
+PF09456 RcsC Alpha-Beta-Loop (ABL)<br>This domain is found in the C-terminus of the phospho-relay kinase RcsC between Pfam:PF00512 and Pfam:PF00072, and forms a discrete alpha/beta/loop structure  .. 
+PF09457 FIP domain <br>The FIP domain is the Rab11-binding domain (RBD) at the C-terminus of a family of Rab11-interacting proteins (FIPs). The Rab proteins constitute the largest family of small GTPases (>60 members in mammals). Among them Rab11 is a well characterised regulator of endocytic and recycling pathways. Rab11 associates with a broad range of post-Golgi organelles, including recycling endosomes  .. 
+PF09458 H-type lectin domain<br>The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates  . It is sometimes found in association with the F5_F8_type_C domain Pfam:PF00754.. 
+PF09459 Ethylbenzene dehydrogenase<br>Eythylbenzene dehydrogenase is a heterotrimer of three subunits that catalyses the anaerobic degradation of hydrocarbons. The alpha subunit contains the catalytic centre as a Molybdenum cofactor-complex. This removes an electron-pair from the hydrocarbon and passes it along an electron transport system involving iron-sulphur complexes held in the beta subunit and a Haem b molecule contained in the gamma subunit. The electron-pair is then subsequently passed to an as yet unknown receiver  . The enzyme is found in a variety of different bacteria.. 
+PF09460 Saf-pilin pilus formation protein<br>This domain consists of the adjacent Saf-Nte and Saf-pilin chains of the pilus-forming complex. Pilus assembly in Gram-negative bacteria involves a Donor-strand exchange mechanism between the C- and the N-termini of this domain. The C-terminal subunit forms an incomplete Ig-fold which is then complemented by the 10-18 residue N-terminus of another, incoming, pilus subunit which is not involved in the Ig-fold. The N-terminus sequences contain a motif of alternating hydrophobic residues that occupy the P2 to P5 binding pockets in the groove of the first pilus subunit  .. 
+PF09461 Phytotoxin PcF protein<br>PcF is a 52 residue protein factor of two alpha helices, containing a 4-hydroxyproline and three cysteine bridges. The presence of the hydroxyproline is unique in relation to other fungal phytotoxic proteins. The protein has a high content of acidic side-chains implying a lack of binding with lipid-rich components of membranes and appears to be an extracellular phytotoxin that causes leaf necrosis in strawberries.. 
+PF09462 Mus7/MMS22 family<br>This family includes a conserved region from the Mus7 protein  . Mus7 is involved in the repair of replication-associated DNA damage in the fission yeast Schizosaccharomyces pombe. Mus7 functions in the same pathway as Mus81, a subunit of the Mus81-Eme1 structure-specific endonuclease, which has been implicated in the repair of the replication-associated DNA damage  . The MMS22 proteins are involved in repairing double-stranded DNA breaks created by the cleavage reaction of topoisomerase II  .. 
+PF09463 Opy2 protein<br>Opy2p acts as a membrane anchor in the HOG signalling pathway  .. 
+PF09465 Lamin-B receptor of TUDOR domain<br>The Lamin-B receptor, found on the TUDOR domain Pfam:PF00567, is a chromatin and lamin binding protein in the inner nuclear membrane. It is one of the integral inner Nuclear Envelope membrane proteins responsible for targeting nuclear membranes to chromatin, being a downstream effector of Ran, a small Ras-like nuclear GTPase which regulates NE assembly. Lamin-B receptor interacts with Importin beta, a Ran-binding protein, thereby directly contributing to the fusion of membrane vesicles and the formation of the NE  .. 
+PF09466 Hypothetical protein Yqai<br>This hypothetical protein is expressed in bacteria, particularly Bacillus subtilis. It forms a homo-dimer, with each monomer containing an alpha helix and four beta strands.. 
+PF09467 Hypothetical protein Yopt<br>This hypothetical protein is expressed in bacteria, particularly Bacillus subtilis. It forms homo-dimers, with each monomer consisting of one alpha helix and three beta strands.. 
+PF09468 Ydr279p protein family (RNase H2 complex component)<br>RNases H are enzymes that specifically hydrolyse RNA when annealed to a complementary DNA and are present in all living organisms. In yeast RNase H2 is composed of a complex of three proteins (Rnh2Ap, Ydr279p and Ylr154p), this family represents the homologues of Ydr279p  . It is not known whether non yeast proteins in this family fulfil the same function.. 
+PF09469 Cordon-bleu ubiquitin-like domain<br>The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node  . This domain has a ubiquitin-like fold.. 
+PF09470 Telethonin protein<br>Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerisation of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles  .. 
+PF09471 IgA Peptidase M64<br>This is a family of highly selective metallo-endopeptidases.  The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase  .. 
+PF09472 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)<br>Many archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This domain is mostly found in MtrF, where it covers the entire length of the protein. This polypeptide is one of eight subunits of the N5-methyltetrahydromethanopterin: coenzyme M methyltransferase complex found in methanogenic archaea. This is a membrane-associated enzyme complex that uses methyl-transfer reactions to drive a sodium-ion pump. MtrF itself is involved in the transfer of the methyl group from N5-methyltetrahydromethanopterin to coenzyme M. Subsequently, methane is produced by two-electron reduction of the methyl moiety in methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase. In some organisms this domain is found at the C terminal region of what appears to be a fusion of the MtrA and MtrF proteins. The function of these proteins is unknown, though it is likely that they are involved in C1 metabolism.. 
+PF09474 type_III_YscX; <br>Type III secretion system YscX (type_III_YscX). Members of this family are encoded within bacterial type III secretion gene clusters. Among all species with type III secretion, those with this protein are found among those that target animal rather than plant cells. The member of this family in Yersinia was shown by mutation to be required for type III secretion of Yops effector proteins and therefore is believed to be part of the secretion machinery.. 
+PF09475 dot_icm_IcmQ; <br>Dot/Icm secretion system protein (dot_icm_IcmQ). Proteins in this entry are the IcmQ component of Dot/Icm secretion systems, as found in the obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii. While this system resembles type IV secretion systems and has been called a form of type IV, the literature now seems to favour calling this the Dot/Icm system. This protein was shown to be essential for translocation.. 
+PF09476 pilus_cpaD; Pilus_cpaD; <br>Pilus biogenesis CpaD protein (pilus_cpaD). Proteins in this entry consist of a pilus biogenesis protein, CpaD, from Caulobacter, and homologues in other bacteria, including three in the root nodule bacterium Bradyrhizobium japonicum. The molecular function of the homologues is not known.. 
+PF09477 type_III_yscG; Type_III_yscG; <br>Bacterial type II secretion system chaperone protein (type_III_yscG). YscG is a molecular chaperone for YscE, where both are part of the type III secretion system that in Yersinia is designated Ysc (Yersinia secretion). The secretion system delivers effector proteins, designated Yops (Yersinia outer proteins), in Yersinia. This entry consists of YscG from Yersinia and functionally equivalent type III secretion proteins in other species: e.g. AscG in Aeromonas and LscG in Photorhabdus luminescens.. 
+PF09478 Carbohydrate binding domain CBM49<br>Mistry J, Urbanowicz B. Pfam-B_6310 (release 21.0). This domain is found at the C terminal of cellulases and in vitro binding studies have shown it to binds to crystalline cellulose  .. 
+PF09479 flg_new; <br>Listeria-Bacteroides repeat domain (List_Bact_rpt). This model describes a conserved core region of about 43 residues, which occurs in at least two families of tandem repeats. These include 78-residue repeats which occur from 2 to 15 times in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats found in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few other bacteria.. 
+PF09480 Type III secretion system protein PrgH-EprH (PrgH)<br>In Salmonella, the gene encoding this protein is part of a four-gene operon PrgHIJK, while in other organisms it is found in type III secretion operons. PrgH has been shown to be required for type III secretion and is a structural component of the needle complex, which is the core component of type III secretion systems.. 
+PF09481 CRISPR_cse1; <br>CRISPR-associated protein Cse1 (CRISPR_cse1). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.. 
+PF09482 Bacterial type III secretion apparatus protein (OrgA_MxiK)<br>This protein is encoded by genes which are found in type III secretion operons, and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene. In Shigella the gene is called MxiK and has been shown to be essential for the proper assembly of the needle complex, which is the core component of type III secretion systems.. 
+PF09483 Type III secretion protein (HpaP)<br>This entry represents proteins encoded by genes which are always found in type III secretion operons, although their function in the processes of secretion and virulence is unclear. Hpa stands for Hrp-associated gene, where Hrp stands for hypersensitivity response and virulence. see also PMID:18584024. 
+PF09484 cas_TM1802; <br>CRISPR-associated protein TM1802 (cas_TM1802). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.. 
+PF09485 CRISPR_cse2; <br>CRISPR-associated protein Cse2 (CRISPR_cse2). Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.. 
+PF09486 Bacterial type III secretion protein (HrpB7)<br>This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.. 
+PF09487 Bacterial type III secretion protein (HrpB2)<br>This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow group of species including Xanthomonas, Burkholderia and Ralstonia.. 
+PF09488 osmo_MPGsynth; <br>Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth). This family consists of examples of mannosyl-3-phosphoglycerate synthase (MPGS), which together with mannosyl-3-phosphoglycerate phosphatase (MPGP) EC:2.4.1.217, comprises a two-step pathway for mannosylglycerate biosynthesis. Mannosylglycerate is a compatible solute that tends to be restricted to extreme thermophiles of archaea and bacteria. Note that in Rhodothermus marinus, this pathway is one of two; the other is condensation of GDP-mannose with D-glycerate by mannosylglycerate synthase.. 
+PF09489 Probable cobalt transporter subunit (CbtB)<br>This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localisation with a protein (CbtA) predicted to have five additional transmembrane segments.. 
+PF09490 Probable cobalt transporter subunit (CbtA)<br>This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of five transmembrane segments, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localisation with a small protein (CbtB) having a single additional transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site.. 
+PF09491 AlwI restriction endonuclease<br>This family includes the AlwI (recognises GGATC), Bsp6I (recognises GC^NGC) , BstNBI (recognises GASTC), PleI(recognises GAGTC) and MlyI (recognises GAGTC) restriction endonucleases.. 
+PF09492 pec_lyase; <br>Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.. 
+PF09493 CHP02450_Tryp; <br>Tryptophan-rich protein (DUF2389). Members of this family are small hypothetical proteins of 60 to 100 residues from Cyanobacteria and some Proteobacteria. Prochlorococcus marinus strains have two members, other species one only. Interestingly, of the eight most conserved residues, four are aromatic and three are invariant tryptophans. It appears all species that encode this protein can synthesise tryptophan de novo.. 
+PF09494 Slx4 endonuclease<br>The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals.  Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates  .. 
+PF09495 UPF0390;<br>Protein of unknown function (DUF2462). This protein is highly conserved, but its function is unknown. It can be isolated from HeLa cell nucleoli and is found to be homologous with Leydig cell tumour protein whose function is unknown [1, supplementary Table I].. 
+PF09496 Cenp-O;<br>Cenp-O kinetochore centromere component. This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere.  It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human   .. 
+PF09497 Transcription mediator complex subunit Med12<br>Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator  .. 
+PF09498 CHP02448; <br>Protein of unknown function (DUF2388). This family consists of small hypothetical proteins, about 100 amino acids in length. The family includes five members (three in tandem) in Pseudomonas aeruginosa PAO1 and in Pseudomonas putida (strain KT2440), four in Pseudomonas syringae DC3000, and single members in several other Proteobacteria. The function is unknown.. 
+PF09499 ApaLI-like restriction endonuclease<br>This family includes R.ApaLI and R.XbaI restriction endonucleases. ApaLI recognises and cleaves the sequence GTGCAC.. 
+PF09500 yiiD_Cterm; <br>Putative thioesterase (yiiD_Cterm). This entry consists of a broadly distributed uncharacterised domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain Pfam:PF00583.. 
+PF09501 Bac_small_yrzI; <br>Probable sporulation protein (Bac_small_yrzI). Members of this family are very small proteins, about 47 residues each, in the genus Bacillus. Single members are found in Bacillus subtilis and Bacillus halodurans, while arrays of six members in tandem are found in Bacillus cereus and Bacillus anthracis. An EIxxE motif present in most members of this family resembles cleavage sites by the germination protease GPR in a number of small acid-soluble spore proteins (SASP). A role in sporulation is possible.. 
+PF09502 Bacterial type III secretion protein (HrpB4)<br>This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.. 
+PF09504 Bsp6I restriction endonuclease<br>This family includes the Bsp6I (recognises and cleaves GC^NGC) restriction endonucleases.. 
+PF09505 Dimethylamine methyltransferase (Dimeth_PyL)<br>This family consists of dimethylamine methyltransferases from the genus Methanosarcina. It is found in three nearly identical copies in each of Methanosarcina acetivorans, Methanosarcina barkeri, and Methanosarcina mazei. It is one of a suite of three non-homologous enzymes with a critical UAG-encoded pyrrolysine residue in these species (along with trimethylamine methyltransferase and monomethylamine methyltransferase). It demethylates dimethylamine, leaving monomethylamine, and methylates the prosthetic group of the small corrinoid protein MtbC. The methyl group is then transferred by methylcorrinoid:coenzyme M methyltransferase to coenzyme M. Note that the pyrrolysine residue is variously translated as K or X, or as a stop codon that truncates the sequence.. 
+PF09506 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase)<br>Proteins in this family are glucosylglycerol-phosphate phosphatases, with the gene symbol stpA (Salt Tolerance Protein A). A motif characteristic of acid phosphatases is found, but otherwise this family shows little sequence similarity to other phosphatases. This enzyme acts on the glucosylglycerol phosphate, product of glucosylglycerol phosphate synthase and immediate precursor of the osmoprotectant glucosylglycerol.. 
+PF09508 CHP02336; <br>Lacto-N-biose phosphorylase. The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolism. The protein appears to be a carbohydrate-processing phosphorolytic enzyme (EC:2.4.1.211), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolism of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.. 
+PF09507 DNA polymerase subunit Cdc27<br>This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterised by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.. 
+PF09509 Hypoth_ymh; <br>Protein of unknown function (Hypoth_ymh). This entry consists of a relatively rare prokaryotic protein family (about 8 occurrences per 200 genomes). Genes for members of this family appear to be associated variously with phage and plasmid regions, restriction system loci, transposons, and housekeeping genes. Their function is unknown.. 
+PF09510 Rtt102p-like transcription regulator protein<br>This protein is found in fungi. The family includes Rtt102p, a transcription regulator protein which appears to be integrally associated with both the Swi-Snf and the RSC chromatin remodelling complexes,  .. 
+PF09511 RNA ligase<br>TIGRFAMs, Coggill P, Mistry J, Wood V. TIGRFAMs & Pfam-B_49998 (release 17.0). Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity  .  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.. 
+PF09512 Thiamine-precursor transporter protein (ThiW)<br>Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.. 
+PF09514 SSXRD motif<br>Pfam-B_23332 (Release 21.0). SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localise to this region  .. 
+PF09515 Thiamine transporter protein (Thia_YuaJ)<br>Members of this protein family have been assigned as thiamine transporters by a phylogenetic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.. 
+PF09516 CfrBI restriction endonuclease<br>This family includes the CfrBI (recognises and cleaves C^CWWGG) restriction endonuclease.. 
+PF09517 Eco29kI restriction endonuclease<br>This family includes the Eco29kI (recognises and cleaves CCGC^GG ) restriction endonuclease.. 
+PF09518 HindIII restriction endonuclease<br>This family includes the HindIII (recognises and cleaves A^AGCTT) restriction endonuclease.. 
+PF09519 HindVP restriction endonuclease<br>This family includes the HindVP (recognises GRCGYC bu the cleavage site is unknown) restriction endonucleases.. 
+PF09520 RE_MjaII;<br>Type II restriction endonuclease, TdeIII. This family includes many TdeIII restriction endonucleases that recognise and cleave at GGNCC sites. TdeIII cleave unmethylated double-stranded DNA  .. 
+PF09521 NgoPII restriction endonuclease<br>This family includes the NgoPII (recognises and cleaves GG^CC) restriction endonuclease.. 
+PF09522 R.Pab1 restriction endonuclease<br>
+PF09523 CHP02444; <br>Protein of unknown function (DUF2390). Members of this family are bacterial hypothetical proteins, about 160 amino acids in length, found in various proteobacteria, including members of the genera Pseudomonas and Vibrio. The C-terminal region is poorly conserved and is not included in the model.. 
+PF09524 Conserved phage C-terminus (Phg_2220_C)<br>This entry represents the conserved C-terminal domain of a family of proteins found exclusively in bacteriophage and in bacterial prophage regions. The functions of this domain and the proteins containing it are unknown.. 
+PF09526 CHP02443; <br>Probable metal-binding protein (DUF2387). Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.. 
+PF09527 Putative F0F1-ATPase subunit (ATPase_gene1)<br>This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme.. 
+PF09528 Ehrlichia tandem repeat (Ehrlichia_rpt)<br>This entry represents 77 residues of an 80 amino acid (240 nucleotide) tandem repeat, found in a variable number of copies in an immunodominant outer membrane protein of Ehrlichia chaffeensis, a tick-borne obligate intracellular pathogen.. 
+PF09529 intg_mem_TP0381; <br>Integral membrane protein (intg_mem_TP0381). This entry represents a family of hydrophobic proteins with seven predicted transmembrane alpha helices. Members are found in Bacillus subtilis (ywaF), TP0381 from Treponema pallidum (TP0381), Streptococcus pyogenes, Rhodococcus erythropolis, etc.. 
+PF09531 Nucleoporin protein Ndc1-Nup<br>Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.. 
+PF09532 DFDF;<br>The FDF domain, so called because of the conserved FDF at its  N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops  . It is found at the C terminus of Scd6p-like SM domains   . It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain  .. 
+PF09533 CHP02269_MYXXA; <br>Predicted lipoprotein of unknown function (DUF2380). This family consists of at least 9 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. One appears truncated toward the N-terminus; the others are predicted lipoproteins. The function is unknown.. 
+PF09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp)<br>Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.. 
+PF09535 Protein of unknown function (Gmx_para_CXXCG)<br>This entry consists of at least 10 paralogous proteins from Myxococcus xanthus and that lack detectable sequence similarity to any other protein family. An imperfectly conserved CXXCG motif, a probable binding site, appears twice in the multiple sequence alignment.. 
+PF09536 Mxa_TIGR02265; <br>Protein of unknown function (DUF2378). This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.. 
+PF09537 CHP2284; <br>Domain of unknown function (DUF2383). Members of this protein family are found mostly in the Proteobacteria, although one member is found in the the marine planctomycete Pirellula sp. strain 1. The function is unknown.. 
+PF09538 Protein of unknown function (FYDLN_acid)<br>Members of this family are bacterial proteins with a conserved motif [KR]FYDLN, sometimes flanked by a pair of CXXC motifs, followed by a long region of low complexity sequence in which roughly half the residues are Asp and Glu, including multiple runs of five or more acidic residues. The function of members of this family is unknown.. 
+PF09539 CHP02301; <br>Protein of unknown function (DUF2385). Members of this uncharacterised protein family are found in a number of alphaproteobacteria, including root nodule bacteria, Brucella suis, Caulobacter crescentus, and Rhodopseudomonas palustris. Conserved residues include two well-separated cysteines, suggesting a disulfide bond. The function is unknown.. 
+PF09543 CHP02267_MYXXA; <br>Protein of unknown function (DUF2379). This family consists of at least 7 paralogs in Myxococcus xanthus and 6 in Stigmatella aurantiaca, both members of the Deltaproteobacteria. The function is unknown.. 
+PF09544 Mxa_TIGR02268; <br>Protein of unknown function (DUF2381). This family consists of at least 8 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. The function is unknown.. 
+PF09545 AccI restriction endonuclease<br>This family includes the AccI (recognises and cleaves GT^MKAC) restriction endonuclease.. 
+PF09546 spore_III_AE; <br>Stage III sporulation protein AE (spore_III_AE). This represents the stage III sporulation protein AE, which is encoded in a spore formation operon spoIIIAABCDEFGH under the control of sigma G. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.. 
+PF09547 spore_IV_A; <br>Stage IV sporulation protein A (spore_IV_A). SpoIVA is designated stage IV sporulation protein A. It acts in the mother cell compartment and plays a role in spore coat morphogenesis. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.. 
+PF09548 spore_III_AB; <br>Stage III sporulation protein AB (spore_III_AB). SpoIIIAB represents the stage III sporulation protein AB, which is encoded in a spore formation operon: spoIIIAABCDEFGH that is under sigma G regulation  . A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.. 
+PF09549 Bpu10I restriction endonuclease<br>This family includes the Bpu10I (recognises and cleaves CCTNAGC (-5/-2)) restriction endonucleases.. 
+PF09550 CHP2216_phage; <br>Conserved hypothetical phage protein (DUF2376). This entry describes a family of proteins found exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA.. 
+PF09551 spore_II_R; <br>Stage II sporulation protein R (spore_II_R). SpoIIR is designated stage II sporulation protein R. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species. SpoIIR is a signalling protein that links the activation of sigma E to the transcriptional activity of sigma F during sporulation.. 
+PF09552 BstXI restriction endonuclease<br>This family includes the BstXI (recognises and cleaves CCANNNNN^NTGG) restriction endonuclease.. 
+PF09553 Eco47II restriction endonuclease<br>This family includes the Eco47II (which recognises GGNCC, but the cleavage site unknown) restriction endonuclease.. 
+PF09554 HaeII restriction endonuclease<br>This family includes the HaeII (recognises and cleaves RGCGC^Y) restriction endonuclease.. 
+PF09556 HaeIII restriction endonuclease<br>This family includes the HaeIII (recognises and cleaves GG^CC) restriction endonuclease.. 
+PF09557 CHP2271_C; <br>Domain of unknown function (DUF2382). This entry describes an uncharacterized domain, sometimes found in association with a PRC-barrel domain Pfam:PF05239 which is also found in rRNA processing protein RimM and in a photosynthetic reaction centre complex protein). This domain is found in proteins from Bacillus subtilis, Deinococcus radiodurans, Nostoc sp. PCC 7120, Myxococcus xanthus, and several other species. The function is not known.. 
+PF09558 CHP02922; <br>Protein of unknown function (DUF2375). TIGRFAMs, Coggilll P. Two members of this family are found in Colwellia psychrerythraea (strain 34H / ATCC BAA-681) and one each in various other species of Colwellia and Shewanella. One member from C. psychrerythraea is of special interest because it is preceded by the same cis-regulatory site as a number of genes that have the PEP-CTERM domain described by PEP_anchor (IPR013424).. 
+PF09559 Cas6 Crispr<br>The Cas6 Crispr family of proteins averaging 140 residues are characterised by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus  . The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes  .. 
+PF09560 Spo_YunB; Spo_yunB; <br>Sporulation protein YunB (Spo_YunB). Spo_YunB is the sporulation protein YunB. In Bacillus subtilis its expression is controlled by sigmaE.The gene YunB seems to code for a protein involved, at least indirectly, in the pathway leading to the activation of sigmaK. Inactivation of YunB delays sigmaK activation and results in reduced sporulation efficiency.. 
+PF09561 HpaII restriction endonuclease<br>This family includes the HpaII (recognises and cleaves C^CGG) restriction endonuclease.. 
+PF09562 LlaMI restriction endonuclease<br>This family includes the LlaMI (recognises and cleaves CC^NGG) restriction endonuclease.. 
+PF09563 LlaJI restriction endonuclease<br>This family includes the LlaJI (recognises GACGC) restriction endonucleases.. 
+PF09564 NgoBV restriction endonuclease<br>This family includes the NgoBV (recognises GGNNCC but cleavage site is unknown) restriction endonuclease.. 
+PF09565 NgoFVII restriction endonuclease<br>This family includes the NgoFVII (recognises GCSGC but cleavage site unknown) restriction endonuclease.. 
+PF09566 SacI restriction endonuclease<br>This family includes the SacI (recognises and cleaves GAGCT^C) restriction endonuclease.. 
+PF09567 MamI restriction endonuclease<br>This family includes the MamI (recognises and cleaves GATNN^NNATC) restriction endonuclease.. 
+PF09568 MjaI restriction endonuclease<br>This family includes the MjaI (recognises CTAG but cleavage site unknown) restriction endonuclease.. 
+PF09569 ScaI restriction endonuclease<br>This family includes the ScaI (recognises and cleaves AGT^ACT) restriction endonuclease.. 
+PF09570 SinI restriction endonuclease<br>This family includes the SinI (recognises and cleaves G^GWCC) restriction endonuclease.. 
+PF09571 XcyI restriction endonuclease<br>This family includes the XcyI (recognises and cleaves C^CCGGG) restriction endonucleases.. 
+PF09572 XamI restriction endonuclease<br>This family includes the XamI (recognises GTCGAC but cleavage site unknown) restriction endonuclease.. 
+PF09573 TaqI restriction endonuclease<br>This family includes the TaqI (recognises and cleaves T^CGA) restriction endonuclease.. 
+PF09574 Short_TIGR02808; <br>Protein  of unknown function (Duf2374). This very small protein (about 46 amino acids) consists largely of a single predicted membrane-spanning region. It is found in Photobacterium profundum SS9 and in three species of Vibrio, always near periplasmic nitrate reductase genes, but far from the periplasmic nitrate reductase genes in Aeromonas hydrophila ATCC 7966.. 
+PF09575 Spore_SspJ; <br>Small spore protein J (Spore_SspJ). Spore_SspJ represents a group of small acid-soluble proteins (SASP) from Bacillus sp., which are present in spores but not in growing cells. The sspJ gene is transcribed in the forespore compartment by RNA polymerase with the forespore-specific sigmaG. Loss of SspJ causes a slight decrease in the rate of spore outgrowth in an otherwise wild-type background.. 
+PF09577 Sporulation protein YpjB (SpoYpjB)<br>These proteins are found in the endospore-forming bacteria which include Bacillus species. In Bacillus subtilis, ypjB was found to be part of the sigma-E regulon. Sigma-E is a sporulation sigma factor that regulates expression in the mother cell compartment. Null mutants of ypjB show a sporulation defect, but this gene is not, however, a part of the endospore formation minimal gene set.. 
+PF09578 Spore cortex protein YabQ (Spore_YabQ)<br>This protein is predicted to span the membrane several times. It is only found in genomes of species that perform sporulation, such as Bacillus subtilis, Clostridium tetani, and other members of the Firmicutes (low-GC Gram-positive bacteria). Mutation of this sigmaE-dependent gene blocks development of the spore cortex. The length of the C-terminal region, which includes some hydrophobic regions, is variable.. 
+PF09579 Sporulation protein YtfJ (Spore_YtfJ)<br>Proteins in this family are encoded by bacterial genomes if, and only if, the species is capable of endospore formation. YtfJ was confirmed in spores of B. subtilis; it appears to be expressed in the forespore under control of SigF.. 
+PF09580 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)<br>This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic, 40-residue C-terminal domain.. 
+PF09581 Stage III sporulation protein AF (Spore_III_AF)<br>This family represents the stage III sporulation protein AF (Spore_III_AF) of the bacterial endospore formation program, which exists in some but not all members of the Firmicutes (formerly called low-GC Gram-positives). The C-terminal region of these proteins is poorly conserved.. 
+PF09582 Iron only nitrogenase protein AnfO (AnfO_nitrog)<br>Proteins in this entry include Anf1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) and AnfO from Azotobacter vinelandii. They are found exclusively in species which contain the iron-only nitrogenase, and are encoded immediately downstream of the structural genes for the nitrogenase enzyme in these species.. 
+PF09583 Phage shock protein G (Phageshock_PspG)<br>This protein was previously designated as YjbO in Escherichia coli. It is found only in genomes that have the phage shock operon (psp), but it is only rarely encoded near other psp genes. The psp regulon is upregulated in response to a number of stress conditions, including ethanol, expression of the filamentous phage secretin protein IV and other secretins and heat shock.. 
+PF09584 Phage shock protein PspD (Phageshock_PspD)<br>Members of this family are phage shock protein PspD, found in a minority of bacteria that carry the defining genes of the phage shock regulon (pspA, pspB, pspC, and pspF). It is found in Escherichia coli, Yersinia pestis, and closely related species, where it is part of the phage shock operon. It is known to be expressed but its function is unknown.. 
+PF09585 Conserved hypothetical protein (Lin0512_fam)<br>This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a well conserved motif GxGxDxHG near the N-terminus.. 
+PF09586 Bacterial membrane protein YfhO<br>Pfam-B_2727 (release 21.0). This protein is a conserved membrane protein  . The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.. 
+PF09587 Bacterial capsule synthesis protein PGA_cap<br>Pfam-B_1441 (release 21.0). This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein  .. 
+PF09588 YqaJ-like viral recombinase domain<br>Pfam-B_3587 (release 21.0). This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit  .. 
+PF09589 HrpA pilus formation protein<br>Pfam-B_3574 (release 21.0). HrpA is an essential component of the type III secretion system (TTSS) which pathogens use to inject virulence factors directly into their host cells, and to cause disease. The TTSS has an Hrp pilus appendage for channelling effector proteins through the plant cell wall and this pilus elongates by the addition of HrpA pilin subunits at the distal end  .. 
+PF09590 Lentivirus surface glycoprotein<br>Pfam-B_3269 (release 21.0). This protein is found in feline immunodeficiency retrovirus. It represents the surface glycoprotein which is found in the polyprotein C-terminal to the Env protein.. 
+PF09591 UPF0328; <br>Protein of unknown function (DUF2463). Pfam-B_3132 (release 21.0). This protein is found in eukaryotic, parasitic microsporidia. Its function is unknown.. 
+PF09592 Protein of unknown function (DUF2031)<br>Pfam-B_2630 (release 21.0). This protein is expressed in Plasmodium; its function is unknown. It may be the product of gene family pyst-b  .. 
+PF09593 Phage_C1; <br>Beta-satellite pathogenicity beta C1 protein. Pfam-B_991 (release 21.0). Cotton leaf-curl disease - CLCuD - is of major economic importance in cotton-growing areas of the far-east. The infectious agent appears to be a single-stranded DNA molecule of approx 1350 nucleotides in length, which, when inoculated with the Begomovirus into cotton, induces symptoms typical of CLCuD. This molecule requires the Begomovirus for replication and encapsidation  . DNA beta encodes a single protein, betaC1. The intracellular distribution of betaC1 is consistent with the hypothesis that it has a role in transporting the DNA A of Begomovirus from the nuclear site of replication to the plasmodesmatal exit sites of the infected cell. The DNA beta-encoded protein, betaC1, is the determinant of both pathogenicity and suppression of gene silencing  .. 
+PF09594 Protein of unknown function (DUF2029)<br>Pfam-B_1780 (release 21.0). This is a putative transmembrane protein from bacteria. It is likely to be conserved between Mycobacterium species  .. 
+PF09595 Metaviral_G glycoprotein<br>Pfam-B_922 (release 21.0). This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated  .. 
+PF09596 MamL-1 domain<br>The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors.. 
+PF09597 IGR protein motif<br>This domain is found in fungal proteins and contains a conserved IGR motif. Its function is unknown.. 
+PF09598 Stm1<br>Pfam-B_39435 (release 21.0). This region is found at the N terminal of the Stm1 protein.  Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein.  It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with CDC13  , and is known to associate with ribosomes and nuclear telomere cap complexes  .. 
+PF09599 Salmonella-Shigella invasin protein C (IpaC_SipC)<br>This entry represents a family of proteins associated with bacterial type III secretion systems, which are injection machines for virulence factors into host cell cytoplasm. Characterized members of this protein family are known to be secreted and are described as invasins, including IpaC from Shigella flexneri and SipC from Salmonella typhimurium. Members may be referred to as invasins, pathogenicity island effectors, and cell invasion proteins.. 
+PF09600 Cyd operon protein YbgE (Cyd_oper_YbgE)<br>This entry describes a small protein of unknown function, about 100 amino acids in length, essentially always found in an operon with CydAB, subunits of the cytochrome d terminal oxidase. It appears to be an integral membrane protein. It is found so far only in the Proteobacteria.. 
+PF09601 Chp_urease_rgn;<br>Protein of unknown function (DUF2459). This conserved hypothetical protein of unknown function is found in several Proteobacteria. Its function is unknown and its genome context is not well-conserved. It is found amid urease genes in at least one species.. 
+PF09602 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)<br>This entry describes a protein found in polyhydroxyalkanoic acid (PHA) gene regions and incorporated into PHA inclusions in Bacillus cereus and Bacillus megaterium. The role of the protein may include amino acid storage.. 
+PF09603 Fibrobacter succinogenes major domain (Fib_succ_major)<br>This domain of about 175 to 200 amino acids is found, in from one to five copies, in over 50 proteins in Fibrobacter succinogenes S85, an obligate anaerobe of the rumen. Many members of this family have an apparent lipoprotein signal sequence. Conserved cysteine residues, suggestive of disulfide bond formation, are also consistent with an extracytoplasmic location for this domain. This domain can also be found in small numbers of proteins in Chlorobium tepidum and Bacteroides thetaiotaomicron.. 
+PF09604 F subunit of K+-transporting ATPase (Potass_KdpF)<br>This entry describes a very small integral membrane peptide KdpF, a subunit of the K(+)-translocating Kdp complex. It is found upstream of the KdpA subunit (IPR004623). Because of its very small size and highly hydrophobic character, it is sometimes missed in genome annotation.. 
+PF09605 Hypothetical bacterial integral membrane protein (Trep_Strep)<br>This family consists of strongly hydrophobic proteins about 190 amino acids in length with a strongly basic motif near the C-terminus. It is found in rather few species, but in paralogous families of 12 members in the oral pathogenic spirochaete Treponema denticola and 2 in Streptococcus pneumoniae R6.. 
+PF09606 ARC105; ARC105_Med_act; <br>ARC105 or Med15 subunit of Mediator complex non-fungal. The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development  .. 
+PF09607 Brinker DNA-binding domain<br>This DNA-binding domain is the first approx. 100 residues of the N-terminal end of Brinker. The structure of this domain in complex with DNA consists of four alpha-helices that contain a helix-turn-helix DNA recognition motif specific for GC-rich DNA. The Brinker nuclear repressor is a major element of the Drosophila Decapentaplegic morphogen signalling pathway  .. 
+PF09608 Putative transmembrane protein (Alph_Pro_TM)<br>This family consists of predicted transmembrane proteins of about 270 amino acids. Members are found, so far, only among the Alphaproteobacteria and only once in each genome.. 
+PF09609 CRISPR-associated protein, GSU0054 family (Cas_GSU0054)<br>This entry represents a rare CRISPR-associated protein. So far, members are found in Geobacter sulfurreducens and in two unpublished genomes: Gemmata obscuriglobus and Actinomyces naeslundii. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.. 
+PF09610 Mycoplasma virulence signal region (Myco_arth_vir_N)<br>This entry represents the N-terminal region of a family of large, virulence-associated proteins in Mycoplasma arthritidis and smaller proteins in Mycoplasma capricolum. It includes a probable signal sequence or signal anchor, which, in most instances, has four consecutive Lys residues before the hydrophobic stretch.. 
+PF09611 CRISPR-associated protein (Cas_Csy1)<br>CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2465 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy1, for CRISPR/Cas Subtype Ypest protein 1.. 
+PF09612 Bacterial protein of unknown function (HtrL_YibB)<br>The protein from this rare, uncharacterized protein family is designated HtrL or YibB in E. coli, where its gene is found in a region of LPS core biosynthesis genes  . Homologues are found in Shigella flexneri, Campylobacter jejuni, and Caenorhabditis elegans only. The htrL gene may represent an insertion to the LPS core biosynthesis region, rather than an LPS biosynthetic protein.. 
+PF09613 Bacterial type III secretion protein (HrpB1_HrpK)<br>This family of proteins is encoded by genes found within type III secretion operons in a limited range of species including Xanthomonas, Ralstonia and Burkholderia.. 
+PF09614 CRISPR-associated protein (Cas_Csy2)<br>CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.. 
+PF09615 CRISPR-associated protein (Cas_Csy3)<br>CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.. 
+PF09617 CRISPR-associated protein GSU0053 (Cas_GSU0053)<br>This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).. 
+PF09618 CRISPR-associated protein (Cas_Csy4)<br>CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.. 
+PF09619 Type III secretion system lipoprotein chaperone (YscW)<br>This entry is encoded within type III secretion operons. The protein has been characterised as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerisation and localisation of YscC.. 
+PF09620 CRISPR-associated protein (Cas_csx3)<br>This entry is encoded in CRISPR-associated (cas) gene clusters, near CRISPR repeats, in the genomes of several different thermophiles: Archaeoglobus fulgidus (archaeal), Aquifex aeolicus (Aquificae), Dictyoglomus thermophilum (Dictyoglomi), and a thermophilic Synechococcus (Cyanobacteria). It is not yet assigned to a specific CRISPR/cas subtype (hence the x designation csx3).. 
+PF09621 Type III secretion system regulator (LcrR)<br>This family of proteins are encoded within type III secretion operons and have been characterised in Yersinia as a regulator of the Low-Calcium Response (LCR).. 
+PF09622 CHP02587; <br>Putative integral membrane protein (DUF2391). This entry is found in Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus in a conserved two-gene neighbourhood. Proteins containing this entry appear to span the membrane seven times.. 
+PF09623 CRISPR-associated protein NE0113 (Cas_NE0113)<br>Members of this minor CRISPR-associated (Cas) protein family are encoded in cas gene clusters in Vibrio vulnificus YJ016, Nitrosomonas europaea ATCC 19718, Mannheimia succiniciproducens MBEL55E, and Verrucomicrobium spinosum.. 
+PF09624 CHP02588; <br>Protein of unknown function (DUF2393). The function of this protein is unknown. It is always found as part of a two-gene operon with IPR013416, a protein that appears to span the membrane seven times. It has so far been found in the bacteria Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus.. 
+PF09625 VP9 protein<br>VP9 is a protein containing a ferredoxin fold. Two dimers come together to form one asymmetric unit which possesses a DNA recognition fold and specific metal binding sites possibly for zinc. It is postulated that being a non-structural protein VP9 is involved in the transcriptional regulation of the White spot syndrome virus, WSSV, from which it comes. WSSV is the major viral pathogen in shrimp aquaculture  . VP9 is found N-terminal to the Pfam:PF07056 domain.. 
+PF09626 Dihaem cytochrome c<br>Dihaem cytochrome c (DHC) is a soluble c-type cytochrome that folds into two distinct domains, each binding a single haem group and connected by a small linker region. Despite little sequence similarity, the N-terminal domain (residues 12-75) is a class I type cytochrome c, that binds one of the haems, but the domain surrounding the other haem is structurally unique. DHC binds electrostatically to an oxygen-binding protein, sphaeroides haem protein (SHP), as a component of a conserved electron transfer pathway.  DHC acts as the physiological electron donor for SHP during phototrophic growth  . In certain species DHC is found upstream of Pfam:PF01292.. 
+PF09627 PrgU-like protein<br>This hypothetical protein of 125 residues is expressed in bacteria but is thought to be plasmid in origin. It forms a six beta-strand barrel with three accompanying alpha helices and is probably a homo-dimer in the cell. It may be involved in pheromone-inducible conjugation  .. 
+PF09628 Yvfg; <br>Yvfg is a hypothetical protein of 71 residues expressed in some bacteria. The monomer consists of two parallel alpha helices, and the protein crystallises as a homo-dimer.. 
+PF09629 YorP protein<br>YorP is a 71 residue protein found in bacteria. As it is also found in a bacteriophage it might be of viral origin. The structure is of an alpha helix between two of five beta strands. The function is unknown.. 
+PF09630 Domain of unknown function (DUF2024)<br>This protein of 86 residues is expressed in bacteria.  It consists of four alpha helices and two beta strands. Its function is unknown. One UniProt entry gives the gene name as Traf5.. 
+PF09631 Sen15 protein<br>The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this hetero-tetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold.  Each monomer consists of three alpha-helices and a mixed antiparallel/parallel beta-sheet. Two monomers of Sen15 fold with two monomers of Sen34, one of the two catalytic subunits, to form an alpha2-beta2 tetramer as part of the functional endonuclease assembly.. 
+PF09632 Rac1-binding domain<br>The Rac1-binding domain is the C-terminal portion of YpkA from Yersinia. It is an all-helical molecule consisting of two distinct subdomains connected by a linker. the N-terminal end, residues 434-615, consists of six helices organised into two three-helix bundles packed against each other. This region is involved with binding to GTPases. The C-terminal end, residues 705-732. is a novel and elongated fold consisting of four helices clustered into two pairs, and this fold carries the helix implicated in actin activation. Rac1-binding domain mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and causing cytoskeletal disruption in the host  . It is usually found downstream of Pfam:PF00069.. 
+PF09633 Protein of unknown function (DUF2023)<br>This protein of approx.120 residues consists of three beta strands and five alpha helices, thought to fold into a homo-dimer. It is expressed in bacteria.. 
+PF09634 Protein of unknown function (DUF2025)<br>This protein is produced from gene PA1123 in Pseudomonas. It contains three alpha helices and six beta strands and is thought to be monomeric.  It appears to be present in the biofilm layer and may be a lipoprotein.. 
+PF09635 MetRS-N binding domain<br>The MetRS-N domain binds an Arc1-P domain in a tetrameric complex resembling a classical GST homo-dimer. Domain-swapping between symmetrically related MetRS-N and Arc1p-N domains generates a 2:2 tetramer held together by van der Waals forces. This domain is necessary for formation of the aminoacyl-tRNA synthetase complex necessary for tRNA nuclear export and shuttling as part of the translational apparatus. The domain is associated with Pfam:PF09334.. 
+PF09636 XkdW protein<br>This protein of approx. 100 residues contains two alpha helices and two beta strands and is probably monomeric. It is expressed in bacteria but is probably viral in origin. Its function is unknown.. 
+PF09637 Med18 protein<br>Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators  .. 
+PF09638 Ph1570 protein<br>This is a hypothetical protein from Pyroccous horikoshii of unknown function.\.    It contains six alpha helices and eight beta strands and is thought to be monomeric.. 
+PF09639 YjcQ protein<br>YjcQ is a protein of approx. 100 residues containing four alpha helices and three beta strands. It is expressed in bacteria and also in viruses. It appears to be under the regulation of SigD RNA polymerase which is responsible for the expression of many genes encoding cell-surface proteins related to flagellar assembly, motility, chemotaxis and autolysis in the late exponential growth phase. The exact function of YjcQ is unknown  . However, it is thought to be a prophage head protein in viruses  .. 
+PF09640 Domain of unknown function (DUF2027)<br>This protein domain is of unknown function. though putatively involved in DNA mismatch repair. It is associated with Pfam:PF01713.. 
+PF09641 Protein of unknown function (DUF2026)<br>This protein of approx. 100 residues is found in bacteria. It contains up to five alpha helices and up to seven beta strands and is probably monomeric. Its function is unknown. It is cited as a major prophage head protein  , so might generally be of viral origin.. 
+PF09642 YonK protein<br>YonK protein is expressed by the bacterial prophage SPbetaC  . It is a 63 residue protein that associates into a homo-octamer in the form of a beta-stranded barrel with four outer helical features at points of the compass.  Its function is unknown.. 
+PF09643 YopX protein<br>YopX is a protein that is largely helical, with three identical chains probably complexing into a twelve-chain structure.. 
+PF09644 Mg296 protein<br>This protein of 129 residues is expressed in bacteria. It consists of three identical chains of five alpha helices.  Two copies of each chain associate into a complex of six units of possible biological significance but of unknown function.. 
+PF09645 F-112 protein<br>F-112 protein is of 70-110 residues and is found in viruses. Its winged-helix structure suggests a DNA-binding function.. 
+PF09646 Gp37 protein<br>This protein of 154 residues consists of a unit of helices and beta sheets that crystallises into a beautiful asymmetrical dodecameric barrel-structure, of two six-membered rings one on top of the other. It is expressed in bacteria but is of viral origin as it is found in phage BcepMu and is probably a pathogenesis factor  .. 
+PF09648 YycH protein<br>Pfam-B_6483 (Release 21.0). This domain is exclusively found in YycI proteins in the low GC content Gram positive species.  These two domains share the same structural fold with domains two and three of YycH   Pfam:PF07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.. 
+PF09649 Histone chaperone domain CHZ<br>This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones  .. 
+PF09650 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)<br>Proteins in this entry are encoded by genes involved in either polyhydroxyalkanoic acid (PHA) biosynthesis or utilisation, including proteins found at the surface of PHA granules. These proteins have so far been found in the Pseudomonadales, Xanthomonadales, and Vibrionales, all of which belong to the Gammaproteobacteria.. 
+PF09651 CRISPR-associated protein (Cas_APE2256)<br>This entry represents a conserved region of about 150 amino acids found in at least five archaeal and three bacterial species. These species all contain CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In six of eight species, the protein is encoded the vicinity of a CRISPR/Cas locus.. 
+PF09652 Putative CRISPR-associated protein (Cas_VVA1548)<br>This entry represents a conserved region of about 95 amino acids found exclusively in species with CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In all bacterial species that contain this entry, the genes encoding the proteins are in the midst of a cluster of cas (CRISPR-associated) genes.. 
+PF09654 CHP02652; <br>Protein of unknown function (DUF2396). These conserved hypothetical proteins have so far been found only in the Cyanobacteria. They are about 170 amino acids long and contain a CxxCx(14)CxxH motif near the N-terminus.. 
+PF09655 Conserved nitrate reductase-associated protein (Nitr_red_assoc)<br>Proteins in this entry are found in the Cyanobacteria, and are mostly encoded near nitrate reductase and molybdopterin biosynthesis genes. Molybdopterin guanine dinucleotide is a cofactor for nitrate reductase. These proteins are sometimes annotated as nitrate reductase-associated proteins, though their function is unknown.. 
+PF09656 CHP02611; <br>Putative transmembrane protein (PGPGW). Proteins in this entry are putative Actinobacterial proteins of about 150 amino acids in length, with three predicted transmembrane helices and an unusual motif with consensus sequence PGPGW.. 
+PF09657 CRISPR-associated protein Csx8 (Cas_Csx8)<br>Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes proteins of unknown function which are encoded in the midst of a cas gene operon.. 
+PF09658 CRISPR-associated protein (Cas_Csx9)<br>Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes archaeal proteins encoded in cas gene regions.. 
+PF09659 CRISPR-associated protein (Cas_Csm6)<br>Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.. 
+PF09660 CHP02677; <br>Protein of unknown function (DUF2397). Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).. 
+PF09661 CHP02678; <br>Protein of unknown function (DUF2398). Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).. 
+PF09662 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma)<br>Members of this protein family are the gamma subunit of phenylphosphate carboxylase. Phenol (methyl-benzene) is converted to phenylphosphate, then para-carboxylated by this four-subunit enzyme, with the release of phosphate, to 4-hydroxybenzoate. The enzyme contains neither biotin nor thiamin pyrophosphate. The gamma subunit has no known homologues.. 
+PF09663 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD)<br>Members of this family are ring-opening amidohydrolases, including cyanuric acid amidohydrolase (EC:3.5.2.15) (AtzD and TrzD) and barbiturase. Note that barbiturase does not act as defined for EC:3.5.2.1 (barbiturate + water = malonate + urea) but rather catalyses the ring opening of barbiturase acid to ureidomalonic acid.. 
+PF09664 CHP02679; <br>Protein of unknown function C-terminus (DUF2399). Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Beta-proteobacteria). Just the C-terminal region is ioncluded here.. 
+PF09665 Type II restriction endonuclease (RE_Alw26IDE)<br>Members of this entry are type II restriction endonucleases of the Alw26I/Eco31I/Esp3I family. Characterised specificities of the three members are GGTCTC, CGTCTC and the shared subsequence GTCTC.. 
+PF09666 Sororin protein<br>Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion  . The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex  .. 
+PF09667 Domain of unknown function (DUF2028)<br>This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.. 
+PF09668 Aspartyl protease<br>Pfam-B_9589 (release 20.0). This family of eukaryotic aspartyl proteases have a fold similar to retroviral proteases which implies they function proteolytically during regulated protein turnover  .. 
+PF09669 Phage regulatory protein Rha (Phage_pRha)<br>Members of this protein family are found in temperate phage and bacterial prophage regions. Members include the product of the rha gene of the lambdoid phage phi-80, a late operon gene. The presence of this gene interferes with infection of bacterial strains that lack integration host factor (IHF), which regulates the rha gene. It is suggested that Rha is a phage regulatory protein.. 
+PF09670 CRISPR-associated protein (Cas_Cas02710)<br>Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).. 
+PF09671 Spore coat protein (Spore_GerQ)<br>Members of this protein family are the spore coat protein GerQ of endospore-forming Firmicutes (low GC Gram-positive bacteria). This protein is cross-linked by a spore coat-associated transglutaminase.. 
+PF09673 Type-F conjugative transfer system pilin assembly protein<br>This entry represents TrbC, a protein that is an essential component of the F-type conjugative pilus assembly system for the transfer of plasmid DNA. The N-terminal portion of these proteins is heterogeneous.. 
+PF09674 CHP02757; <br>Protein of unknown function (DUF2400). Members of this uncharacterised protein family are found sporadically, so far only among spirochetes, epsilon and delta proteobacteria, and Bacteroides. The function is unknown and its gene neighbourhoods show little conservation.. 
+PF09675 Chlamydia-phage Chp2 scaffold (Chlamy_scaf)<br>Members of this entry are encoded by genes in chlamydia-phage such as Chp2. These viruses have around eight genes and obligately infect intracellular bacterial pathogens of the genus Chlamydia. This protein is annotated as VP3 or structural protein (as if a protein of mature viral particles), however, it is displaced from procapsids as DNA is packaged, and therefore is more correctly described as a scaffolding protein.. 
+PF09676 Type IV conjugative transfer system lipoprotein (TraV)<br>This entry includes TraV, which is a component of conjugative type IV secretion system. TraV is an outer membrane lipoprotein that is believed to interact with the secretin TraK. The alignment contains three conserved cysteines in the N-terminal half.. 
+PF09677 Type-F conjugative transfer system protein (TrbI_Ftype)<br>This entry represents TrbI, an essential component of the F-type conjugative transfer system for plasmid DNA transfer that has been shown to be localized to the periplasm.. 
+PF09678 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)<br>Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.. 
+PF09679 Type-F conjugative transfer system pilin chaperone (TraQ)<br>This entry represents TraQ, a protein that makes a specific interaction with pilin (TraA) to aid its transfer through the inner membrane during the process of F-type conjugative pilus assembly.. 
+PF09680 Protein of unknown function (Tiny_TM_bacill)<br>This entry represents a family of hypothetical proteins, half of which are 40 residues or less in length. Members are found only in spore-forming species. A Gly-rich variable region is followed by a strongly conserved, highly hydrophobic region, predicted to form a transmembrane helix, ending with an invariant Gly. The consensus for this stretch is FALLVVFILLIIV.. 
+PF09681 N-terminal phage replisome organiser (Phage_rep_org_N)<br>This entry represents the N-terminal domain of a small family of phage proteins. The protein contains a region of low-complexity sequence that reflects DNA direct repeats able to function as an origin of phage replication. The region is N-terminal to the low-complexity region.. 
+PF09682 Phage holin protein (Holin_LLH)<br>This entry identifies a family of putative phage holin from a number of phage and prophage regions of Gram-positive bacteria. Like other holins, it is small (about 100 amino acids) with stretches of hydrophobic sequence and is encoded adjacent to lytic enzymes.. 
+PF09683 Bacteriocin (Lactococcin_972)<br>These sequences represent bacteriocins related to lactococcin. Members tend to be found in association with a seven transmembrane putative immunity protein.. 
+PF09684 Phage tail protein (Tail_P2_I)<br>These sequences represent the family of phage P2 protein I and related tail proteins from a number of temperate phage of Gram-negative bacteria.. 
+PF09685 Tic20-like protein<br>TIGRFAMs & Jackhmmer:D3PVW8. Chloroplast function requires the import of nuclear encoded proteins from the cytoplasm across the chloroplast double membrane. This is accomplished by two protein complexes, the Toc complex located at the outer membrane and the Tic complex located at the inner membrane. The Toc complex recognises specific proteins by a cleavable N-terminal sequence and is primarily responsible for translocation through the outer membrane, while the Tic complex translocates the protein through the inner membrane. This entry represents Tic20, a core member of the Tic complex. This protein is deeply embedded in the inner envelope membrane and is thought to function as a protein- conducting component of the Tic complex. This family also includes many proteins of unknown function from non-synthetic organisms.. 
+PF09686 Plasmid protein of unknown function (Plasmid_RAQPRD)<br>This entry identifies a family of proteins, which are about 100 amino acids in length, including a predicted signal sequence and a perfectly conserved motif RAQPRD towards the C terminus. Members are found in the Pseudomonas putida TOL plasmid pWW0 and in cryptic plasmid regions of Salmonella enterica subsp. enterica serovar Typhi and Pseudomonas syringae DC3000. The function of these proteins are unknown.. 
+PF09687 P_fal_TIGR01639; PHIST_a_b; PHIST_a_c; PRESAC; DUF3837; PRESAC;<br>Plasmodium RESA N-terminal. The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc   has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localise to membranes  .. 
+PF09688 CHP1606_PLAF3D7; <br>Protein of unknown function (Wx5_PLAF3D7). This set of protein sequences represent a family of at least four proteins in Plasmodium falciparum (isolate 3D7). An interesting feature is five perfectly conserved Trp residues.. 
+PF09689 Plasmodium yoelii repeat (PY_rept_46)<br>This repeat is found in the products of only 2 genes in Plasmodium yoelii, in each of these proteins it is repeated 9 times. It is found in no other organism.. 
+PF09690 Plasmodium yoelii subtelomeric region (PYST-C1)<br>This group of sequences are defined by the N-terminal domain of a paralogous family of Plasmodium yoelii genes preferentially located in the subtelomeric regions of the chromosomes. There are no obvious homologues to these genes in any other organism. The C-terminal portions of the genes that contain this domain are divergent and some contain other yoelii-specific paralogous domains such as PYST-C2 (IPR006491).. 
+PF09691 Bacterial chaperone lipoprotein (PulS_OutS)<br>This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family.. 
+PF09692 Argonaute siRNA chaperone (ARC) complex subunit Arb1<br>Arb1 is required for histone H3 Lys9 (H3-K9) methylation, heterochromatin, assembly and siRNA generation in fission yeast  .. 
+PF09693 Phage uncharacterised protein (Phage_XkdX)<br>This entry identifies a family of small (about 50 amino acid) phage proteins, found in at least 12 different phage and prophage regions of Gram-positive bacteria. In a number of these phage, the gene for this protein is found near the holin and endolysin genes.. 
+PF09694 Bacterial protein of unknown function (Gcw_chp)<br>This entry represents a conserved hypothetical protein about 240 residues in length found so far in Proteobacteria including Shewanella oneidensis and Ralstonia solanacearum, usually as part of a paralogous family. The function is unknown.. 
+PF09695 Bacterial protein of unknown function (YtfJ_HI0045)<br>These are sequences from gamma proteobacteria that are related to the E. coli protein, YtfJ.. 
+PF09696 Ctf8<br>Pfam-B_46199 (release 21.0). Ctf8 (chromosome transmissions fidelity 8) is a component of the Ctf18 RFC-like complex which is a DNA clamp loader involved in sister chromatid cohesion.. 
+PF09697 Protein of unknown function (Porph_ging)<br>This family of proteins of unknown function is found in Porphyromonas gingivalis (Bacteroides gingivalis).. 
+PF09698 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH)<br>This motif occurs from three to eight times in eight different proteins of Geobacter sulfurreducens. The final CXXCH motif matches the cytochrome c family haem-binding site signature, suggesting that the sequence may be involved in haem-binding.. 
+PF09699 Doubled CXXCH motif (Paired_CXXCH_1)<br>This entry represents a domain of about 41 amino acids that contains, among other motifs, two copies of the motif CXXCH associated with haem binding. This domain is predicted to be a high molecular weight c-type cytochrome and is often found in multiple copies. Members are found mostly in species of Shewanella, Geobacter, and Vibrio.. 
+PF09700 CRISPR-associated protein (Cas_Cmr3)<br>CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.. 
+PF09701 CRISPR-associated protein (Cas_Cmr5)<br>CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.. 
+PF09702 CRISPR-associated protein (Cas_Csa5)<br>CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry represents a minor family of Cas proteins found in various species of Sulfolobus and Pyrococcus (all archaeal). It is found with two different CRISPR loci in Sulfolobus solfataricus.. 
+PF09703 CRISPR-associated protein (Cas_Csa4)<br>CRISPR loci appear to be mobile elements with a wide host range. This entry represents a protein that tends to be found near CRISPR repeats. The species range for this species, so far, is exclusively archaeal. It is found so far in only four different species, and includes two tandem genes in Pyrococcus furiosus DSM 3638. CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.. 
+PF09704 CRISPR-associated protein (Cas_Cas5)<br>CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum.. 
+PF09706 CRISPR-associated protein (Cas_CXXC_CXXC)<br>CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes a conserved region of about 65 amino acids from an otherwise highly divergent protein found in a minority of CRISPR-associated protein regions. This region features two motifs of CXXC.. 
+PF09707 CRISPR-associated protein (Cas_Cas2CT1978)<br>This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.. 
+PF09709 CRISPR-associated protein (Cas_Csd1)<br>CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.. 
+PF09710 Treponema clustered lipoprotein (Trep_dent_lipo)<br>This entry represents a family of six predicted lipoproteins from a region of about 20 tandemly arranged genes in the Treponema denticola genome. Two other neighbouring genes share the lipoprotein signal peptide region but do not show more extensive homology. The function of this locus is unknown.. 
+PF09711 CRISPR-associated protein (Cas_Csn2)<br>CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins found only in CRISPR-containing species, near other CRISPR-associated proteins (cas). The species range so far for these proteins is pathogenic bacteria only. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats).. 
+PF09712 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)<br>This entry represents the PhaE subunit of the heterodimeric class (class III) of polymerase for poly(R)-hydroxyalkanoic acids (PHAs), carbon and energy storage polymers of many bacteria. The most common PHA is polyhydroxybutyrate but about 150 different constituent hydroxyalkanoic acids (HAs) have been identified in various species.. 
+PF09713 Plant protein 1589 of unknown function (A_thal_3526)<br>This plant-specific family of proteins is defined by an uncharacterised region 57 residues in length. It is found toward the N terminus of most proteins that contain it. Examples include at least several proteins from Arabidopsis thaliana and Oryza sativa. The function of the proteins are unknown.. 
+PF09715 Plasmodium protein of unknown function (Plasmod_dom_1)<br>These sequences represent an uncharacterised family consisting of a small number of hypothetical proteins of the malaria parasite Plasmodium falciparum (isolate 3D7).. 
+PF09716 Malarial early transcribed membrane protein (ETRAMP)<br>These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homologue from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.. 
+PF09717 Plasmodium falciparum domain of unknown function (CPW_WPC)<br>This group of sequences is defined by a domain of about 61 residues in length with six well-conserved cysteine residues and six well-conserved aromatic sites. The domain can be found in tandem repeats, and is known so far only in Plasmodium falciparum. It is named for motifs of CPxxW and (less well conserved) WPC. Its function is unknown.. 
+PF09718 Lambda phage tail tape-measure protein (Tape_meas_lam_C)<br>This represents a relatively well-conserved region near the C terminus of the tape measure protein of a lambda and related phage. The protein, which controls phage tail length, is typically about 1000 residues in length. Both low-complexity sequence and insertion/deletion events appear common in this family. Mutational studies suggest a ruler or template role in the determination of phage tail length. Similar behaviour is attributed to proteins from distantly related or unrelated families in other phage.. 
+PF09719 Putative redox-active protein (C_GCAxxG_C_C)<br>This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.. 
+PF09720 Stabl_TIGR02574; <br>Putative addiction module component. This entry defines several short bacterial proteins, typically about 75 amino acids long, which are always found as part of a pair (at least) of small genes. The other protein in the pair always belongs to a family of plasmid stabilisation proteins (IPR007712). It is likely that this protein and its partner comprise some form of addiction module - a pair of genes consisting of a stable toxin and an unstable antitoxin which mediate programmed cell death - although these gene-pairs are usually found on the bacterial main chromosome.. 
+PF09721 Transmembrane exosortase (Exosortase_EpsH)<br>Members of this family are designated exosortase, analogous to sortase in cell wall sorting mediated by LPXTG domains in Gram-positive bacteria. The phylogenetic distribution of the proteins in this entry is nearly perfectly correlated with the distribution of the proteins having the PEP-CTERM anchor motif, IPR013424. Members of this entry are integral membrane proteins with eight predicted transmembrane helices in common. Some members of this family have long trailing sequences past the region described by this model. This model does not include the region of the first predicted transmembrane region. The best characterised member is EpsH of Methylobacillus sp. 12S, where it is part of a locus associated with biosynthesis of the exopolysaccharide methanol-an.. 
+PF09722 CHP2293; <br>Protein of unknown function (DUF2384). Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. The function is unknown.. 
+PF09723 CxxC_CxxC_SSSS;<br>This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.. 
+PF09724 Uncharacterized conserved protein (DUF2036)<br>This family of proteins includes members ranging in size from approximately 300 to 460 residues. There are a number of well-conserved domains along the length.. 
+PF09725 Folate-sensitive fragile site protein Fra10Ac1<br>This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved protein, of unknown function that is nuclear and highly expressed in brain  .. 
+PF09726 Transmembrane protein<br>This entry is a highly conserved protein present in eukaryotes.. 
+PF09727 Cortactin-binding protein-2<br>This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans.  The human protein has six associated ankyrin repeat domains Pfam:PF00023 towards the C-terminus which act as protein-protein interaction domains  .. 
+PF09728 Myosin-like coiled-coil protein<br>Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells  . Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localises to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription  .. 
+PF09729 Gti1/Pac2 family<br>In S. pombe the gti1 protein promotes the onset of gluconate uptake upon glucose starvation  . In S. pombe the Pac2 protein controls the onset of sexual development, by inhibiting the expression of ste11, in a pathway that is independent of the cAMP cascade  .. 
+PF09730 Microtubule-associated protein Bicaudal-D<br>BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta Pfam:PF05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells  .. 
+PF09731 Mitochondrial inner membrane protein<br>Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex  . The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain.  In addition, it has three centrally located coiled coil domains  .. 
+PF09732 Cactin; <br>Cactus-binding C-terminus of cactin protein. CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo  . Most members of the family also have a Cactin_mid domain Pfam:PF10312 further upstream.. 
+PF09733 VEFS-Box of polycomb protein<br>The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterised by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain  . Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression  .. 
+PF09734 RNA polymerase III transcription factor (TF)IIIC subunit<br>TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.. 
+PF09735 Membrane-associated apoptosis protein<br>Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease  . It is involved in the regulation of actin polymerisation in the brain as part of a WAVE2 signalling complex  .. 
+PF09736 DUF2050; <br>Pre-mRNA-splicing factor of RES complex. This entry is characterised by proteins with alternating conserved and low-complexity regions. Bud13 together with Snu17p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex. called The RES complex, pre-mRNA retention and splicing complex. Subunits of this complex are not essential for viability of yeasts but they are required for efficient splicing in vitro and in vivo. Furthermore, inactivation of this complex causes pre-mRNA leakage from the nucleus. Bud13 contains a unique, phylogenetically conserved C-terminal region of unknown function  .. 
+PF09737 De-etiolated protein 1 Det1<br>
+PF09738 Double stranded RNA binding protein (DUF2051)<br>This is a novel protein identified as interacting with the leucine-rich repeat domain of human flightless-I, FliI protein.. 
+PF09739 DUF2044;<br>Mini-chromosome maintenance replisome factor. This entry is of proteins of approximately 600 residues in length containing alternating regions of conservation and low complexity.  The Arabidopsis protein is a replisome factor found to bind with the mini-chromosome maintenance, MCM-binding, complex and is crucial for efficient DNA replication.. 
+PF09740 Uncharacterized conserved protein (DUF2043)<br>This is a 100 residue conserved region of a family of proteins found from fungi to humans.  This region contains three conserved Cysteines and a motif of {CP}{y/l}{HG}.. 
+PF09741 Uncharacterized conserved protein (DUF2045)<br>This entry is the conserved 250 residues of proteins of approximately 450 amino acids. It contains several highly conserved motifs including a CVxLxxxD motif.The function is unknown.. 
+PF09742 Dyggve-Melchior-Clausen syndrome protein<br>Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteristically about 700 residues long and present in plants and animals.  Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterised by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation  . DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus  . . 
+PF09743 Uncharacterized conserved protein (DUF2042)<br>This entry is the conserved N-terminal 300 residues of a group of proteins found from protozoa to Humans.  The function is unknown.. 
+PF09744 JNK_SAPK-associated protein-1<br>This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF Pfam:PF00621 domain at their C-terminal end.. 
+PF09745 Coiled-coil domain-containing protein 55 (DUF2040)<br>This entry is a conserved domain of approximately 130 residues of proteins conserved from fungi to humans. The proteins do contain a coiled-coil domain, but the function is unknown.. 
+PF09746 Tumour-associated protein<br>Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers  . Membralin-like gene homologues have been identified in plants including grape, cotton and tomato  .. 
+PF09747 Coiled-coil domain containing protein (DUF2052)<br>This entry is of sequences of two conserved domains separated by a region of low complexity, spanning some 200 residues. The function is unknown.. 
+PF09748 Transcription factor subunit Med10 of Mediator complex<br>Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription  . Med10 is part of the middle region of Mediator  .. 
+PF09749 Uncharacterised conserved protein<br>This entry is of proteins of approximately 300 residues conserved from plants to humans.  It contains two conserved motifs, HxSL and FHVSL. The function is unknown.. 
+PF09750 DRY; <br>Alternative splicing regulator  . This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins.  This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA  . These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains Pfam:PF01805 and an Arginine- serine-rich binding region towards the C-terminus.. 
+PF09751 Nuclear protein Es2<br>This entry is of a family of proteins of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong.  Apart from a predicted coiled-coil domain, no other known functional domains have been characterised. The protein appears to be expressed in the nucleus and particularly highly in the pons sub-region of the brain. The protein is clearly necessary for normal development of the nervous system  .. 
+PF09752 Uncharacterized conserved protein (DUF2048)<br>The proteins in this family are conserved from plants to vertebrates. The function is unknown.. 
+PF09753 Membrane fusion protein Use1<br>This entry is of a family of proteins all approximately 300 residues in length. The proteins have a single C-terminal trans-membrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are essential for membrane fusion and are conserved from yeasts to humans. Use1 is one of the three protein subunits that make up the SNARE complex and it is specifically required for Golgi-endoplasmic reticulum retrograde transport.. 
+PF09754 HCCA3;<br>This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits  .. 
+PF09755 Uncharacterized conserved protein H4 (DUF2046)<br>This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.. 
+PF09756 DDRGK domain<br>This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.. 
+PF09757 Arb2 domain<br>A second fission yeast Argonaute complex (Argonaute siRNA chaperone, ARC) that contains two previously uncharacterized proteins, Arb1 and Arb2, both of which are required for histone H3 Lys9 (H3-K9) methylation, heterochromatin assembly and siRNA generation  . This family includes a region found in Arb2 and the Hda1 protein.. 
+PF09758 Uncharacterised conserved protein<br>This entry represents an N-terminal region of approximately 150 residues of a family of proteins of unknown function. It contains a highly conserved FPL motif.. 
+PF09759 Spinocerebellar ataxia type 10 protein domain<br>This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localisation, specifically to the olivocerebellar region  .. 
+PF09762 Coiled-coil domain-containing protein (DUF2037)<br>This entry represents the conserved N-terminal 200 residues of a family of proteins conserved from plants to vertebrates. In Drosophila it comes from the Fidipidine gene, and is of unknown function.. 
+PF09763 Sec3;<br>Exocyst complex component Sec3. This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.. 
+PF09764 WDYHV;<br>N-terminal glutamine amidase. This protein is conserved from plants to humans. It represents a family of N terminal glutamine amidases. The enzyme removes the NH2 group from a Gln, at the N-terminal, rendering it a Glu.. 
+PF09765 WD-repeat region<br>This entry is of a region of approximately 100 residues containing three WD repeats and six cysteine residues possibly as three cystine-bridges. These regions are contained within the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2. The WD repeats are required for interaction with other subunits of the FA complex.. 
+PF09766 Fms-interacting protein<br>This entry carries part of the crucial 144 N-terminal residues of the FmiP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C-terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.. 
+PF09767 Predicted membrane protein (DUF2053)<br>This entry is of the conserved N-terminal 150 residues of proteins conserved from plants to humans. The function is unknown although some annotation suggests it to be a transmembrane protein.. 
+PF09768 Ku70-bp; <br>Peptidase M76 family. This is a family of metalloproteases.  Proteins in this family are also annotated as Ku70-binding proteins.. 
+PF09769 Apolipoprotein O<br>Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL  .. 
+PF09770 Topoisomerase II-associated protein PAT1<br>Members of this family are necessary for accurate chromosome transmission during cell division  . . 
+PF09771 Transmemb_18; Tmem18A; <br>Transmembrane protein 188. The function of this family of transmembrane proteins has not, as yet, been determined.. 
+PF09772 Transmemb_26; <br>Transmembrane protein 26. The function of this family of transmembrane proteins has not, as yet, been determined.. 
+PF09773 Meckelin (Transmembrane protein 67)<br>Members of this family are thought to be related to the ciliary basal body.  Defects result in Meckel syndrome type 3, [MIM:607361], an autosomal recessive disorder characterised by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Joubert syndrome type 6 [MIM:610688] is also a manifestation of certain mutations; it is an autosomal recessive congenital malformation of the cerebellar vermis and brainstem with abnormalities of axonal decussation (crossing in the brain) affecting the corticospinal tract and superior cerebellar peduncles. Individuals with Joubert syndrome have motor and behavioral abnormalities, including an inability to walk due to severe clumsiness and 'mirror' movements, and cognitive and behavioural disturbances   .. 
+PF09774 Caffeine-induced death protein 2<br>Members of this family of proteins mediate the disruption of the DNA replication checkpoint (S-M checkpoint) mechanism caused by caffeine.. 
+PF09775 Keratinocyte-associated protein 2<br>Members of this family comprise various keratinocyte-associated proteins. Their exact function has not, as yet, been determined.. 
+PF09776 Mitochondrial ribosomal protein L55<br>Members of this family are involved in mitochondrial biogenesis and G2/M phase cell cycle progression. They form a component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.. 
+PF09777 Osteopetrosis-associated transmembrane protein 1 precursor<br>Members of this family of proteins are required for osteoclast and melanocyte maturation and function. Mutations give rise to autosomal recessive osteopetrosis [MIM:259700]; also called autosomal recessive Albers-Schonberg disease.. 
+PF09778 Guanylylate cyclase<br>Members of this family of proteins catalyse the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate.. 
+PF09779 DUF2349;<br>Ima1 N-terminal domain. This domain occurs at the N-terminus of the Schizosaccharomyces pombe inner nuclear membrane protein, Ima1. Ima1 interacts with other inner nuclear membrane proteins [1-2].. 
+PF09781 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit<br>Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol   .. 
+PF09782 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit<br>Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol  .. 
+PF09783 Vacuolar import and degradation protein<br>Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole   .. 
+PF09784 Mitochondrial ribosomal protein L31<br>Pfam-B_24102 (release 21.0). This is a family of mitochondrial ribosomal proteins.  L31 is essential for mitochondrial function in yeast  .. 
+PF09785 Prp31 C terminal domain<br>Pfam-B_7665 (release 21.0). This is the C terminal domain of the pre-mRNA processing factor Prp31.  Prp31 is required for U4/U6.U5 tri-snRNP formation  . In humans this protein has been linked to autosomal dominant retinitis pigmentosa   .. 
+PF09786 Cytochrome B561, N terminal<br>Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterised proteins.. 
+PF09787 Golgin subfamily A member 5<br>Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterised: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1  .. 
+PF09788 Transmemb_55A; Tmem55A; <br>Transmembrane protein 55A. Members of this family catalyse the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.. 
+PF09789 Uncharacterized coiled-coil protein (DUF2353)<br>Members of this family of uncharacterised proteins have no known function.. 
+PF09790 Hyccin<br>Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterised by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs   .. 
+PF09791 Oxidoreductase-like protein, N-terminal<br>Members of this family are found in the N terminal region of various oxidoreductase like proteins. Their exact function is, as yet, unknown.. 
+PF09792 DUF2295; <br>Ubiquitin 3 binding protein But2 C-terminal domain. Pfam-B_45554 (release 21.0). This family is of proteins conserved in yeasts. It binds to Uba3 and is involved in the NEDD8 signalling pathway  . This family represents a presumed C-terminal domain.. 
+PF09793 Anticodon-binding domain<br>This domain of approximately 100 residues is conserved from plants to humans. It is frequently found in association with Lsm domain-containing proteins. It is an anticodon-binding domain of a prolyl-tRNA synthetase, whose PDB structure is available under the identifier 1h4q.. 
+PF09794 Transport protein Avl9<br>Pfam-B_12001 (release 21.0). Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo  .. 
+PF09795 Autophagy-related protein 31<br>Pfam-B_60001 (release 21.0). Autophagy is an intracellular degradation system that responds to nutrient starvation.  Cis1/Atg31 has been shown to be required for autophagosome formation in Saccharomyces cerevisiae  .  It interacts with Atg17  .. 
+PF09796 Ubiquinol-cytochrome-c reductase complex subunit (QCR10)<br>The QCR10 family of proteins are a component of the ubiquinol-cytochrome c reductase complex (also known as complex III or cytochrome b-c1 complex).  This complex is located on the inner mitochondrial membrane and it couples electron transfer from ubiquinol to cytochrome.  This subunit (QCR10) is required for stable association of the iron-sulfur protein with the complex  .. 
+PF09797 N-acetyltransferase B complex (NatB) non catalytic subunit<br>Pfam-B_12009 (release 21.0). This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyses the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met.  In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1.  NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions.  This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1  .. 
+PF09798 DNA damage checkpoint protein<br>Pfam-B_41058 (release 21.0). This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1  .. 
+PF09799 Transmemb_17; Tmem17; <br>Predicted membrane protein. KOGs (KOG4694), (KOG4502). This is a 100 amino acid region of a family of proteins conserved from nematodes to humans. It is predicted to be a transmembrane region but its function is not known.. 
+PF09801 Integral membrane protein S linking to the trans Golgi network<br>Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1)  . Sys1p is a small integral membrane protein with four predicted transmembrane domains that localises to the Trans Golgi network TGN in yeast and human cells  .. 
+PF09802 Preprotein translocase subunit Sec66<br>Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures     .. 
+PF09803 Uncharacterized conserved protein (DUF2346)<br>Members of this family of proteins have no known function.. 
+PF09804 Uncharacterized conserved protein (DUF2347)<br>Members of this family of hypothetical proteins have no known function.. 
+PF09805 Nucleolar protein 12 (25kDa)<br>Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit  . The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export  .. 
+PF09806 Cyclin-dependent kinase 2-associated protein<br>Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.. 
+PF09807 Uncharacterized conserved protein (DUF2348)<br>Members of this family of putative uncharacterized proteins have no known function.. 
+PF09808 Small nuclear RNA activating complex (SNAPc), subunit SNAP43<br>Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.. 
+PF09809 MRP_L27; <br>Mitochondrial ribosomal protein L27. Members of this family of proteins are components of the mitochondrial ribosome large subunit. They are also involved in apoptosis and cell cycle regulation.. 
+PF09810 Morph_protein1;<br>Exonuclease V - a 5' deoxyribonuclease. Exonuclease V is a monomeric 5' deoxyribonuclease that is localised in the nucleus. It degrades single-stranded, but not double-stranded, DNA from the 5'-end, and the products are dinucleotides, except the 3'-terminal tri- and tetranucleotides, which are not degraded. The initial hydrolytic cut of exonuclease V on the dephosphorylated substrate produces a mixture of dinucleoside monophosphates and trinucleoside diphosphates. The enzyme is processive in action  . Exo5 is specific for single-stranded DNA and does not hydrolyze RNA. However, Exo5 has the capacity to slide across 5' double-stranded DNA or 5' RNA sequences and resume cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively  .. 
+PF09811 Essential protein Yae1, N terminal<br>Members of this family are found in the N terminal region of the essential protein Yae1. Their exact function has not, as yet, been determined. The family DUF1715, Pfam:PF08215 has now been merged into this family.. 
+PF09812 MRP_L28; <br>Mitochondrial ribosomal protein L28. Members of this family are components of the mitochondrial large ribosomal subunit.  Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S)   .. 
+PF09813 Coiled-coil domain-containing protein 56<br>Members of this family of proteins have no known function.. 
+PF09814 DUF2351;<br>HECT-like Ubiquitin-conjugating enzyme (E2)-binding. HECT_2 is a family of UbcH10-binding proteins.. 
+PF09815 XK-related protein<br>Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems   .. 
+PF09816 RNA polymerase II transcription elongation factor<br>Members of this family act as transcriptional transactivators of ELL and ELL2 elongation activities     . Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. The N-terminus of approx 120 residues is globular and highly conserved  .. 
+PF09817 Uncharacterized conserved protein (DUF2352)<br>Members of this family of uncharacterised proteins have no known function.. 
+PF09818 Predicted ATPase of the ABC class<br>Members of this family include various bacterial predicted ABC class ATPases.. 
+PF09819 ABC-type cobalt transport system, permease component<br>Members of this family of prokaryotic proteins include various hypothetical proteins as well as ABC-type cobalt transport systems.. 
+PF09820 Predicted AAA-ATPase<br>Pfam-B_5377 (release 16.0). This family contains many hypothetical bacterial proteins.  This family was previously the N-terminal part of the Pfam DUF1703 (Pfam:PF08011) family before it was split into two.  This region is predicted to be an AAA-ATPase domain  .. 
+PF09821 ABC_transp; AAA_36;<br>C-terminal AAA-associated domain. This had been thought to be an ATPase domain of ABC-transporter proteins. However, only one member has any trans-membrane regions. It is associated with an upstream ATP-binding cassette family, Pfam:PF00005.. 
+PF09822 ABC-type uncharacterized transport system<br>This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.. 
+PF09823 Domain of unknown function (DUF2357)<br>This entry was previously the N terminal portion of DUF524 (Pfam:PF04411) before it was split into two.  This domain has no known function.  It is predicted to adopt an all beta secondary structure pattern followed by mainly alpha-helical structures  .. 
+PF09824 ArsR transcriptional regulator<br>Members of this family of archaeal proteins are conserved transcriptional regulators belonging to the ArsR family.. 
+PF09825 Biotin-protein ligase, N terminal<br>The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase catalytic domain.. 
+PF09826 Beta propeller domain<br>Members of this family comprise secreted bacterial proteins containing C-terminal beta-propeller domain distantly related to WD-40 repeats.. 
+PF09827 CRISPR associated protein Cas2<br>Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.. 
+PF09828 Chromate resistance exported protein<br>Members of this family of bacterial proteins, are involved in the reduction of chromate accumulation and are essential for chromate resistance.. 
+PF09829 Uncharacterized protein conserved in bacteria (DUF2057)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09830 ATP adenylyltransferase<br>Members of this family of proteins catabolise Ap4N nucleotides (where N is A,C,G or U). Additionally they catalise the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulphate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP  .. 
+PF09831 Uncharacterized protein conserved in bacteria (DUF2058)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09832 Uncharacterized protein conserved in bacteria (DUF2059)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09834 Predicted membrane protein (DUF2061)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09835 Uncharacterized protein conserved in bacteria (DUF2062)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09836 Uncharacterized protein conserved in bacteria (DUF2063)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09837 Uncharacterized protein conserved in bacteria (DUF2064)<br>This family has structural similarity to proteins in the nucleotide-diphospho-sugar transferases superfamily. The similarity suggests that it is an enzyme with a sugar substrate.. 
+PF09838 Uncharacterized protein conserved in bacteria (DUF2065)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09839 Uncharacterized protein conserved in bacteria (DUF2066)<br>This domain, found in various prokaryotic proteins, has no known function.. 
+PF09840 Uncharacterized protein conserved in archaea (DUF2067)<br>This domain, found in various archaeal proteins, has no known function.. 
+PF09842 Predicted membrane protein (DUF2069)<br>This domain, found in various prokaryotes, has no known function.. 
+PF09843 Predicted membrane protein (DUF2070)<br>This domain of unknown function is found in various bacterial hypothetical proteins, as well as in prokaryotic polyketide synthase.. 
+PF09844 Uncharacterized conserved protein (COG2071)<br>This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.. 
+PF09845 Zn-ribbon containing protein (DUF2072)<br>This archaeal protein has no known function.. 
+PF09846 Uncharacterized protein conserved in archaea (DUF2073)<br>This archaeal protein has no known function.. 
+PF09847 Predicted permease (DUF2074)<br>This domain, found in various archaeal hypothetical proteins, has no known function.. 
+PF09848 Uncharacterized conserved protein (DUF2075)<br>This domain, found in various prokaryotic proteins (including putative ATP/GTP binding proteins), has no known function.. 
+PF09849 Uncharacterized protein conserved in bacteria (DUF2076)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.. 
+PF09850 Uncharacterized protein conserved in bacteria (DUF2077)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09851 DUF2078;<br>Short C-terminal domain. 
+PF09852 Predicted membrane protein (DUF2079)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09853 Putative transposon-encoded protein (DUF2080)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09855 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)<br>This domain, found in various hypothetical prokaryotic proteins, as well as some Zn-ribbon nucleic-acid-binding proteins has no known function.. 
+PF09856 Predicted transcriptional regulator (DUF2083)<br>This domain is found in various prokaryotic transcriptional regulatory proteins belonging to the XRE family. Its exact function is, as yet, unknown.. 
+PF09857 Uncharacterized protein conserved in bacteria (DUF2084)<br>This domain, found in various hypothetical prokaryotic proteins,as well as proteins belonging to the UPF0386 family, has no known function.. 
+PF09858 Predicted membrane protein (DUF2085)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09859 DUF2086;<br>Oxygenase, catalysing oxidative methylation of damaged DNA. This family of bacterial sequences is predicted to catalyse oxidative de-methylation of damaged bases in DNA.. 
+PF09860 Uncharacterized protein conserved in bacteria (DUF2087)<br>This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF09861 Domain of unknown function (DUF2088)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09862 Protein of unknown function (DUF2089)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function. This domain is a zinc-ribbon.. 
+PF09863 Uncharacterized protein conserved in bacteria (DUF2090)<br>This domain, found in various prokaryotic carbohydrate kinases, has no known function.. 
+PF09864 DUF2091;<br>Membrane-bound lysozyme-inhibitor of c-type lysozyme. Lysozymes are ancient and important components of the innate immune system of animals that hydrolyse peptidoglycan, the major bacterial cell wall polymer. Various mechanisms have evolved by which bacteria can evade this bactericidal enzyme, one being the production of lysozyme inhibitors. MliC (membrane bound lysozyme inhibitor of c-type lysozyme) of E. coli and Pseudomonas aeruginosa, possess lysozyme inhibitory activity and confer increased lysozyme tolerance upon expression in E. coli  . Structural analyses show that the invariant loop of MliC plays a crucial role in the inhibition of the lysozyme by its insertion into the active site cleft of the lysozyme, where the loop forms hydrogen and ionic bonds with the catalytic residues  .. 
+PF09865 Predicted periplasmic protein (DUF2092)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09866 Uncharacterized protein conserved in bacteria (DUF2093)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09867 Uncharacterized protein conserved in bacteria (DUF2094)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09868 Uncharacterized protein conserved in archaea (DUF2095)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09869 Uncharacterized protein conserved in archaea (DUF2096)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09870 Uncharacterized protein conserved in archaea (DUF2097)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09871 Uncharacterized protein conserved in archaea (DUF2098)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09872 Uncharacterized protein conserved in archaea (DUF2099)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09873 Uncharacterized protein conserved in archaea (DUF2100)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09874 Predicted membrane protein (DUF2101)<br>This domain, found in various archaeal and bacterial proteins, has no known function.. 
+PF09875 Uncharacterized protein conserved in archaea (DUF2102)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09876 Predicted metal-binding protein (DUF2103)<br>This domain, found in various putative metal binding prokaryotic proteins, has no known function.. 
+PF09877 Predicted membrane protein (DUF2104)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09878 Predicted membrane protein (DUF2105)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09879 Predicted membrane protein (DUF2106)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09880 Predicted membrane protein (DUF2107)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09881 Predicted membrane protein (DUF2108)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09882 Predicted membrane protein (DUF2109)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09883 Uncharacterized protein conserved in archaea (DUF2110)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09884 Uncharacterized protein conserved in archaea (DUF2111)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09885 Uncharacterized protein conserved in archaea (DUF2112)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09886 Uncharacterized protein conserved in archaea (DUF2113)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09887 Uncharacterized protein conserved in archaea (DUF2114)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09888 Uncharacterized protein conserved in archaea (DUF2115)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09889 Uncharacterized protein containing a Zn-ribbon (DUF2116)<br>This domain, found in various hypothetical archaeal proteins, has no known function.  Structural modelling suggests this domain may bind nucleic acids  .. 
+PF09890 Uncharacterized protein conserved in archaea (DUF2117)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09891 Uncharacterized protein conserved in archaea (DUF2118)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09892 Uncharacterized protein conserved in archaea (DUF2119)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09893 Uncharacterized protein conserved in archaea (DUF2120)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09894 Uncharacterized protein conserved in archaea (DUF2121)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09895 RecB-family nuclease (DUF2122)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09897 Uncharacterized protein conserved in archaea (DUF2124)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09898 Uncharacterized protein conserved in bacteria (DUF2125)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09899 Putative amidoligase enzyme (DUF2126)<br>Members of this family of bacterial domains are predominantly found in transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown, but they are likely to act as amidoligase enzymes   Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes)  .. 
+PF09900 Predicted membrane protein (DUF2127)<br>COGs (COG4331&COG3305)). This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.. 
+PF09902 Uncharacterized protein conserved in bacteria (DUF2129)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF09903 Uncharacterized protein conserved in bacteria (DUF2130)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09904 DUF2131;<br>Winged helix-turn helix. This family, found in various hypothetical prokaryotic proteins, is a probable winged helix DNA-binding domain.. 
+PF09905 Uncharacterized conserved protein (DUF2132)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09906 Uncharacterized protein conserved in bacteria (DUF2135)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09907 Uncharacterized protein conserved in bacteria (DUF2136)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09909 Uncharacterized protein conserved in bacteria (DUF2138)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09910 Uncharacterized protein conserved in archaea (DUF2139)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09911 Uncharacterized protein conserved in bacteria (DUF2140)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09912 Uncharacterized protein conserved in bacteria (DUF2141)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09913 Predicted membrane protein (DUF2142)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09916 Uncharacterized protein conserved in bacteria (DUF2145)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09917 Uncharacterized protein conserved in bacteria (DUF2147)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09918 Uncharacterized protein containing a ferredoxin domain (DUF2148)<br>This domain, found in various hypothetical bacterial proteins containing a ferredoxin domain, has no known function.. 
+PF09919 Uncharacterized conserved protein (DUF2149)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09920 Uncharacterized protein conserved in archaea (DUF2150)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09921 Uncharacterized protein conserved in archaea (DUF2153)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09922 Cell wall-active antibiotics response protein (DUF2154)<br>
+PF09923 Uncharacterized protein conserved in bacteria (DUF2155)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09924 Uncharacterized conserved protein (DUF2156)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09925 Predicted membrane protein (DUF2157)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09926 Uncharacterized small protein (DUF2158)<br>Members of this family of prokaryotic proteins have no known function.. 
+PF09928 Predicted small integral membrane protein (DUF2160)<br>The members of this family of hypothetical prokaryotic proteins have no known function. It is thought that they are transmembrane proteins, but their function has not been inferred yet.. 
+PF09929 Uncharacterized conserved protein (DUF2161)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09930 Predicted transporter (DUF2162)<br>Members of this family of bacterial proteins are thought to be membrane transporters, but their exact function has not, as yet, been elucidated.. 
+PF09931 Uncharacterized conserved protein (DUF2163)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09932 Uncharacterized conserved protein (DUF2164)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09933 Predicted small integral membrane protein (DUF2165)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09935 Protein of unknown function (DUF2167)<br>This domain, found in various hypothetical membrane-anchored prokaryotic proteins, has no known function.. 
+PF09936 DUF2168;<br>SAM-dependent RNA methyltransferase. This family has a Rossmanoid fold, with a deep trefoil knot in its C-terminal region. It has structural similarity to RNA methyltransferases, and is likely to function as an S-adenosyl-L-methionine (SAM)-dependent RNA 2'-O methyltransferase  .. 
+PF09937 Uncharacterized protein conserved in bacteria (DUF2169)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09938 Uncharacterized protein conserved in bacteria (DUF2170)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09939 Uncharacterized protein conserved in bacteria (DUF2171)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09940 Domain of unknown function (DUF2172)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function. An aminopeptidase domain is conserved within the family, but its relevance has not been established yet.. 
+PF09941 Uncharacterized conserved protein (DUF2173)<br>This domain, found in various hypothetical prokaryotic proteins, has no known function.. 
+PF09943 Uncharacterized protein conserved in archaea (DUF2175)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09945 Predicted membrane protein (DUF2177)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09946 Predicted membrane protein (DUF2178)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09947 Uncharacterized protein conserved in archaea (DUF2180)<br>This domain, found in various hypothetical archaeal proteins, has no known function. A few of the family members contain a zinc finger domain.. 
+PF09948 Predicted metal-binding integral membrane protein (DUF2182)<br>This domain, found in various hypothetical bacterial membrane proteins having predicted metal-binding properties, has no known function.. 
+PF09949 Uncharacterized conserved protein (DUF2183)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09950 Uncharacterized protein conserved in bacteria (DUF2184)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09951 Protein of unknown function (DUF2185)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09952 Uncharacterized protein conserved in bacteria (DUF2186)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09953 Uncharacterized protein conserved in bacteria (DUF2187)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09954 Uncharacterized protein conserved in bacteria (DUF2188)<br>COGs (COG4876) & Jackhmmer:B5ZC26. This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09955 Predicted integral membrane protein (DUF2189)<br>Members of this family are found in various hypothetical prokaryotic proteins, as well as putative cytochrome c oxidases. Their exact function has not, as yet, been established.. 
+PF09956 Uncharacterized conserved protein (DUF2190)<br>This domain, found in various hypothetical prokaryotic proteins, as well as in some putative RecA/RadA recombinases, has no known function.. 
+PF09957 Uncharacterized protein conserved in bacteria (DUF2191)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09958 Uncharacterized protein conserved in archaea (DUF2192)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09959 Uncharacterized protein conserved in archaea (DUF2193)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09960 Uncharacterized protein conserved in bacteria (DUF2194)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09961 Uncharacterized protein conserved in bacteria (DUF2195)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09962 Uncharacterized conserved protein (DUF2196)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09963 Uncharacterized protein conserved in bacteria (DUF2197)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09964 Uncharacterized protein conserved in bacteria (DUF2198)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09965 Uncharacterized protein conserved in bacteria (DUF2199)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09966 Uncharacterized protein conserved in bacteria (DUF2200)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09967 VWA-like domain (DUF2201)<br>This domain, found in various hypothetical bacterial proteins, has no known function. However, it is clearly related to the VWA domain.. 
+PF09968 Uncharacterized protein domain (DUF2202)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09969 Uncharacterized conserved protein (DUF2203)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09970 Nucleotidyl transferase of unknown function (DUF2204)<br>This domain, found in various hypothetical archaeal proteins, has no known function. However, this family was identified as belonging to the nucleotidyltransferase superfamily  .. 
+PF09971 Predicted membrane protein (DUF2206)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09972 Predicted membrane protein (DUF2207)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09973 Predicted membrane protein (DUF2208)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09974 Uncharacterized protein conserved in archaea (DUF2209)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09976 DUF2133;<br>Tetratricopeptide repeat. 
+PF09977 DUF2134;<br>Putative Tad-like Flp pilus-assembly. This domain, found in various hypothetical prokaryotic proteins, is likely to be involved in Flp lius biogenesis.. 
+PF09979 Uncharacterized protein conserved in bacteria (DUF2213)<br>Members of this family of bacterial proteins comprise various hypothetical and phage-related proteins. The exact function of these proteins has not, as yet, been determined.. 
+PF09980 Predicted membrane protein (DUF2214)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09981 Uncharacterized protein conserved in bacteria (DUF2218)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09982 Uncharacterized protein conserved in bacteria (DUF2219)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09983 Uncharacterized protein conserved in bacteria C-term(DUF2220)<br>This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the C-terminus.. 
+PF09984 Uncharacterized signal transduction histidine kinase domain (DUF2222)<br>Members of this family of domains are found in various BarA-like signal transduction histidine kinases, which are involved in the regulation of carbon metabolism via the csrA/csrB regulatory system. The role of this domain has not, as yet, been established.. 
+PF09985 Domain of unknown function (DUF2223)<br>Members of this family are found in various prokaryotic membrane-anchored proteins predicted to be involved in the regulation of amylopullulanase.. 
+PF09986 Uncharacterized protein conserved in bacteria (DUF2225)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09987 Uncharacterized protein conserved in archaea (DUF2226)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF09988 Uncharacterized metal-binding protein (DUF2227)<br>Members of this family of hypothetical bacterial proteins possess metal binding properties; however, their exact function has not, as yet, been determined.. 
+PF09989 CoA enzyme activase uncharacterised domain (DUF2229)<br>Members of this family include various bacterial hypothetical proteins, as well as CoA enzyme activases. The exact function of this domain has not, as yet, been defined.. 
+PF09990 Predicted membrane protein (DUF2231)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09991 Predicted membrane protein (DUF2232)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09992 Predicted periplasmic protein (DUF2233)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09994 Uncharacterized alpha/beta hydrolase domain (DUF2235)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09995 Uncharacterized protein conserved in bacteria (DUF2236)<br>This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.. 
+PF09996 Uncharacterized protein conserved in bacteria (DUF2237)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09997 Predicted membrane protein (DUF2238)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09998 Uncharacterized protein conserved in bacteria (DUF2239)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF09999 Uncharacterized protein conserved in archaea (DUF2240)<br>This domain, found in various hypothetical archaeal proteins, has no known function.. 
+PF10000 DUF2241;<br>This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241.. 
+PF10001 Uncharacterized protein conserved in bacteria (DUF2242)<br>This domain is found in various hypothetical bacterial proteins, and has no known function.. 
+PF10002 Predicted membrane protein (DUF2243)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10003 Integral membrane protein (DUF2244)<br>This domain, found in various bacterial hypothetical and putative membrane proteins, has no known function.. 
+PF10004 Uncharacterized protein conserved in bacteria (DUF2247)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10005 Uncharacterized protein conserved in bacteria (DUF2248)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10006 Uncharacterized conserved protein (DUF2249)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10007 Uncharacterized protein conserved in archaea (DUF2250)<br>Members of this family of hypothetical archaeal proteins have no known function.. 
+PF10008 Uncharacterized protein conserved in bacteria (DUF2251)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10009 Uncharacterized protein conserved in bacteria (DUF2252)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10011 Predicted membrane protein (DUF2254)<br>Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.. 
+PF10012 Uncharacterized protein conserved in bacteria (DUF2255)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10013 Uncharacterized protein conserved in bacteria (DUF2256)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10014 DUF2257; BsmA;<br>This family contains 2-oxoglutarate (2OG) and Fe-dependent dioxygenases. It includes L-isoleucine dioxygenase (IDO)  .. 
+PF10015 Uncharacterized protein conserved in archaea (DUF2258)<br>Members of this family of hypothetical bacterial archaeal have no known function.  Structural modelling suggests this domain may bind nucleic acids  .. 
+PF10016 Predicted secreted protein (DUF2259)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10017 DUF2260;<br>Histidine-specific methyltransferase, SAM-dependent. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring  .. 
+PF10018 VDRIP; <br>Vitamin-D-receptor interacting Mediator subunit 4. Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter   .. 
+PF10020 Uncharacterized protein conserved in bacteria (DUF2262)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10021 Uncharacterized protein conserved in bacteria (DUF2263)<br>This domain, found in various hypothetical bacterial and eukaryotic proteins, has no known function.. 
+PF10022 Uncharacterized protein conserved in bacteria (DUF2264)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10023 Predicted aminopeptidase (DUF2265)<br>Members of this family of bacterial proteins comprise various hypothetical proteins and putative aminopeptidases. Their exact function, has not, as yet, been defined.. 
+PF10025 Uncharacterized conserved protein (DUF2267)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10026 Predicted Zn-dependent protease (DUF2268)<br>This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.. 
+PF10027 Predicted integral membrane protein (DUF2269)<br>Members of this family of bacterial hypothetical integral membrane proteins have no known function.. 
+PF10028 Predicted integral membrane protein (DUF2270)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10029 Predicted periplasmic protein (DUF2271)<br>This domain, found in various hypothetical bacterial proteins and misannotated lysozyme proteins, it has no known function.. 
+PF10030 Uncharacterized protein conserved in bacteria (DUF2272)<br>Members of this family of hypothetical bacterial proteins have no known function. However, given its similarity to the CHAP domain it seems likely that this is an enzyme involved in cleaving peptidoglycan.. 
+PF10031 Small integral membrane protein (DUF2273)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10032 Phosphate transport (Pho88)<br>Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance     .. 
+PF10033 Autophagy-related protein 13<br>Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage    .. 
+PF10034 DUF2211;<br>Q-cell neuroblast polarisation. Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants  . The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.. 
+PF10035 Uncharacterized protein conserved in bacteria (DUF2179)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10036 Putative carnitine deficiency-associated protein<br>This family of proteins conserved from nematodes to humans is of approximately 250 amino acids. It is purported to be carnitine deficiency-associated protein but this could not be confirmed. It carries a characteristic RLL sequence-motif. The function is unknown.. 
+PF10037 MRP_S27; <br>Mitochondrial 28S ribosomal protein S27. Members of this family of small ribosomal proteins possess one of three conserved blocks of sequence found in proteins that stimulate the dissociation of guanine nucleotides from G-proteins, leaving open the possibility that MRP-S27 might be a functional partner of GTP-binding ribosomal proteins  .. 
+PF10038 Protein of unknown function (DUF2274)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10039 Predicted integral membrane protein (DUF2275)<br>This domain, found in various hypothetical bacterial proteins and in the RNA polymerase sigma factor, has no known function.. 
+PF10040 Uncharacterized conserved protein (DUF2276)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10041 Uncharacterized conserved protein (DUF2277)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10042 Uncharacterized conserved protein (DUF2278)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10043 Predicted periplasmic lipoprotein (DUF2279)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10044 Retinal tissue protein<br>Rtp is a family of proteins of approximately 112 amino acids in length which is conserved from nematodes to humans. The proposed tertiary structure is of almost entirely alpha helix interrupted only by loops located at proline residues. Three sites in the protein sequence reveal two types of possible post-translation modification. A serine residue, at position 41, is a candidate for protein kinase C phosphorylation. Glycine residues at position 69 and 91 are probable sites for acetylation by covalent amide linkage of myristate via N-myristoyl transferase. Rtp is differentially expressed in the trout retina between parr and smolt developmental stages (smoltification). It is likely to be a house-keeping protein  .. 
+PF10045 Uncharacterized conserved protein (DUF2280)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10046 Biogenesis of lysosome-related organelles complex-1 subunit 2 <br>Members of this family of proteins play a role in cellular proliferation, as well as in the biogenesis of specialized organelles of the endosomal-lysosomal system.. 
+PF10047 Protein of unknown function (DUF2281)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10048 Predicted integral membrane protein (DUF2282)<br>Members of this family of hypothetical bacterial proteins and putative signal peptide proteins have no known function.. 
+PF10049 Protein of unknown function (DUF2283)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10050 Predicted metal-binding protein (DUF2284)<br>Members of this family of metal-binding hypothetical bacterial proteins have no known function.. 
+PF10051 Uncharacterized protein conserved in archaea (DUF2286)<br>Members of this family of hypothetical archaeal proteins have no known function.. 
+PF10052 Protein of unknown function (DUF2288)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10053 Uncharacterized conserved protein (DUF2290)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10054 Predicted periplasmic lipoprotein (DUF2291)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10055 Uncharacterized small protein (DUF2292)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10056 Uncharacterized conserved protein (DUF2293)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10057 Uncharacterized conserved protein (DUF2294)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10058 Predicted integral membrane metal-binding protein (DUF2296)<br>This domain, found in various hypothetical bacterial and eukaryotic metal-binding proteins, has no known function.. 
+PF10060 Uncharacterized membrane protein (DUF2298)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10061 Uncharacterized conserved protein (DUF2299)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10062 Predicted secreted protein (DUF2300)<br>This domain, found in various bacterial hypothetical and putative signal peptide proteins, has no known function.. 
+PF10063 Uncharacterized integral membrane protein (DUF2301)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10065 Uncharacterized conserved protein (DUF2303)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10066 Uncharacterized conserved protein (DUF2304)<br>Members of this family of hypothetical archaeal proteins have no known function.. 
+PF10067 Predicted membrane protein (DUF2306)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10069 DUF2308;<br>Sensory domain found in DIguanylate Cyclases & Two-component systems. DICT is a sensory domain found associated with GGDEF, EAL, HD-GYP STAS, and two component systems  . It assumes an alpha+beta fold  with a 4-stranded beta-sheet and might have a role in light response  .. 
+PF10070 Uncharacterized protein conserved in bacteria (DUF2309)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10071 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)<br>Members of this family of proteobacterial zinc ribbon proteins are thought to bind to nucleic acids, however their exact function has not as yet been defined.. 
+PF10073 Uncharacterized protein conserved in bacteria (DUF2312)<br>Members of this family of hypothetical bacterial proteins have no known function. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF10074 Uncharacterized conserved protein (DUF2285)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10075 COP9 signalosome, subunit CSN8<br>This PCI_Csn8 domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome).  It functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development  .. 
+PF10076 Uncharacterized protein conserved in bacteria (DUF2313)<br>Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins.. 
+PF10077 Uncharacterized protein conserved in bacteria (DUF2314)<br>This domain is found in various bacterial hypothetical proteins, as well as putative ankyrin repeat proteins. The exact function of the domains comprising this family has not, as yet, been determined.. 
+PF10078 Uncharacterized protein conserved in bacteria (DUF2316)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10079 Uncharacterized protein conserved in bacteria (DUF2317)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10080 Predicted membrane protein (DUF2318)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10081 DUF2319;<br>Alpha/beta-hydrolase family. This is a family of alpha/beta hydrolases which may function as lipases. This domain is the catalytic domain and includes the catalytic triad and the GXSXG sequence motif which is a characteristic of these enzymes  .. 
+PF10082 Uncharacterized protein conserved in bacteria (DUF2320)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10083 Uncharacterized protein conserved in bacteria (DUF2321)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10084 Uncharacterized protein conserved in bacteria (DUF2322)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10086 Putative membrane peptidase family (DUF2324)<br>This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family Pfam:PF02517, suggesting this family may be peptidases.. 
+PF10087 Uncharacterized protein conserved in bacteria (DUF2325)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10088 Uncharacterized protein conserved in bacteria (DUF2326)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10090 Uncharacterized protein conserved in bacteria (DUF2328)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10091 DUF2329;<br>Putative glucoamylase. The structure of UniProt:Q5LIB7 has an alpha/alpha toroid fold and is similar structurally to a number of glucoamylases. Most of these structural homologues are glucoamylases, involved in breaking down complex sugars (e.g. starch). The biologically relevant state is likely to be monomeric. The putative active site is located at the centre of the toroid with a well defined large cavity.. 
+PF10092 Uncharacterized protein conserved in bacteria (DUF2330)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10093 Uncharacterized protein conserved in bacteria (DUF2331)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10094 Uncharacterized protein conserved in bacteria (DUF2332)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10095 Uncharacterized protein conserved in bacteria (DUF2333)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10096 Uncharacterized protein conserved in bacteria (DUF2334)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10097 Predicted membrane protein (DUF2335)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10098 Uncharacterized protein conserved in bacteria (DUF2336)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10099 DUF2337;<br>Anti-sigma-K factor rskA. This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83  .. 
+PF10100 Uncharacterized protein conserved in bacteria (DUF2338)<br>Members of this family of hypothetical bacterial proteins have no known function.. 
+PF10101 Predicted membrane protein (DUF2339)<br>This domain, found in various hypothetical bacterial proteins, has no known function.. 
+PF10102 Domain of unknown function (DUF2341)<br>Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.. 
+PF10103 Uncharacterised conserved protein (DUF2342)<br>Members of this family of bacterial hypothetical and uncharacterised proteins have no known function.. 
+PF10104 DUF2343; <br>Di-sulfide bridge nucleocytoplasmic transport domain. COGs (COG5085), KOGs (KOG4503). Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport  . Brr6 in yeast is an essential integral membrane protein of the NE-ER, wit two predicted transmembrane domains, and is a dosage suppressor of Apq12, Pfam:PF12716  .. 
+PF10105 Uncharacterized protein conserved in bacteria (DUF2344)<br>This domain, found in various hypothetical bacterial proteins and Radical Sam domain proteins, has no known function.. 
+PF10106 Uncharacterized protein conserved in bacteria (DUF2345)<br>Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.. 
+PF10107 Endonuclease related to archaeal Holliday junction resolvase<br>This domain is found in various predicted bacterial endonucleases which are distantly related to archaeal Holliday junction resolvases.. 
+PF10108 Exon_PolB;<br>Predicted 3'-5' exonuclease related to the exonuclease domain of PolB. This domain is found in various prokaryotic 3'-5' exonucleases and hypothetical proteins.. 
+PF10109 Mu-like prophage FluMu protein gp41<br>Jackhmmer:Q1GH51.1(1-98). Members of this family of prokaryotic proteins include various gp41 proteins and related sequences  .. 
+PF10110 Membrane domain of glycerophosphoryl diester phosphodiesterase<br>Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.. 
+PF10111 GlycosTransf;<br>Glycosyltransferase like family 2. Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis   .. 
+PF10112 5-bromo-4-chloroindolyl phosphate hydrolysis protein<br>Members of this family of prokaryotic proteins mediate the hydrolysis of 5-bromo-4-chloroindolyl phosphate bonds.. 
+PF10113 Fibrillarin-like archaeal protein<br>Members of this family of proteins include archaeal fibrillarin homologs.. 
+PF10114 Hist_Kin_Sens;<br>Sensory domain found in PocR. PocR, a ligand binding domain, has a novel variant of the PAS-like Fold   . Evidence suggests that it binds small hydrocarbon  derivatives such as 1,3-propanediol  . . 
+PF10115 Transcriptional activator HlyU<br>This domain, found in various hypothetical prokaryotic proteins, has no known function. One of the sequences in this family corresponds to the transcriptional activator HlyU, indicating a possible similar role in other members.. 
+PF10116 Protein required for attachment to host cells<br>Members of this family of bacterial proteins are required for the attachment of the bacterium to host cells   .. 
+PF10117 McrBC 5-methylcytosine restriction system component<br>Members of this family of bacterial proteins modify the specificity of mcrB restriction by expanding the range of modified sequences restricted   .. 
+PF10118 Predicted metal-dependent hydrolase<br>Members of this family of proteins comprise various bacterial transition metal-dependent hydrolases.. 
+PF10119 Predicted methyltransferase regulatory domain<br>Members of this family of domains are found in various prokaryotic methyltransferases, where they regulate the activity of the methyltransferase domain.. 
+PF10120 MethylPyrKinase;<br>Members of this family of archaeal and bacterial proteins are likely to be aldolases.. 
+PF10122 Mu-like prophage protein Com<br>Members of this family of proteins comprise the translational regulator of mom   .. 
+PF10123 Mu-like prophage I protein<br>Members of this family of proteins comprise various viral Mu-like prophage I proteins.. 
+PF10124 Mu-like prophage major head subunit gpT<br>Members of this family of proteins comprise various caudoviral prophage proteins, including the Mu-like prophage major head subunit gpT.. 
+PF10125 NADH dehydrogenase I, subunit N related protein<br>This family comprises a set of NADH dehydrogenase I, subunit N related proteins found in archaea. Their exact function, has not, as yet, been determined.. 
+PF10126 Uncharacterized protein, homolog of nitrogen regulatory protein PII<br>This domain, found in various hypothetical archaeal proteins, has no known function. It is distantly similar to the nitrogen regulatory protein PII.. 
+PF10127 Predicted nucleotidyltransferase<br>Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.. 
+PF10128 Glucose-6-phosphate dehydrogenase subunit<br>Members of this family are found in various prokaryotic OpcA and glucose-6-phosphate dehydrogenase proteins. The exact function of the domain is, as yet, unknown.. 
+PF10129 OpgC protein<br>This domain, found in various hypothetical and OpgC prokaryotic proteins. It is likely to act as an acyltransferase enzyme.. 
+PF10130 PIN domain<br>Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).. 
+PF10131 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein<br>This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.. 
+PF10133 Predicted RNA-binding protein<br>Members of this family of bacterial proteins are thought to have RNA-binding properties, however, their exact function has not, as yet, been defined.. 
+PF10134 Replication initiator protein A<br>Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.. 
+PF10135 Rod binding protein<br>Members of this family are involved in the assembly of the prokaryotic flagellar rod.. 
+PF10136 Site-specific recombinase<br>Members of this family of bacterial proteins are found in various putative site-specific recombinase transmembrane proteins.. 
+PF10137 Predicted nucleotide-binding protein containing TIR-like domain<br>Members of this family of bacterial nucleotide-binding proteins contain a TIR-like domain. Their exact function has not, as yet, been defined.. 
+PF10138 Tellurium_res;<br>vWA found in TerF C terminus . vWA domain fused to TerD domain typified by the  TerF protein  . Some times found as solos. . 
+PF10139 Putative bacterial virulence factor<br>Members of this family of prokaryotic proteins include various putative virulence factor effector proteins. Their exact function is, as yet, unknown.. 
+PF10140 essB;<br>WXG100 protein secretion system (Wss), protein YukC. Members of this family of proteins include predicted membrane proteins homologous to YukC in B. subtilis. The YukC protein family would participate to the formation of a translocon required for the secretion of WXG100 proteins (Pfam:PF06013) in monoderm bacteria, the WXG100 protein secretion system (Wss). This family includes EssB in Staphylococcus aureus.. 
+PF10141 Single-strand DNA-specific exonuclease, C terminal domain<br>Members of this set of prokaryotic domains are found in a set of single-strand DNA-specific exonucleases, including RecJ. Their exact function has not, as yet, been determined.. 
+PF10142 PhoPQ-activated pathogenicity-related protein<br>Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria  .. 
+PF10143 2,3-bisphosphoglycerate-independent phosphoglycerate mutase<br>Members of this family are found in various bacterial 2,3-bisphosphoglycerate-independent phosphoglycerate mutase enzymes, which catalyse the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate].. 
+PF10144 Bacterial virulence factor haemolysin<br>Members of this family of bacterial proteins are membrane proteins that effect the expression of haemolysin under anaerobic conditions  .. 
+PF10145 Phage-related minor tail protein<br>Members of this family are found in putative phage tail tape measure proteins. . 
+PF10146 Zinc finger-containing protein <br>This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.. 
+PF10147 Growth arrest and DNA-damage-inducible proteins-interacting protein 1<br>Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity  .. 
+PF10148 Schwannomin-interacting protein 1<br>Members of this family are coiled coil protein involved in linking membrane proteins to the cytoskeleton.. 
+PF10149 NAcGluc_Transf;<br>Transmembrane protein 231. This is a family of transmembrane proteins, given the number 231, of unknown function. It is conserved in eukaryotes.. 
+PF10150 Ribonuclease E/G family<br>Pfam-B_234 (Release 21.0). Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs  .. 
+PF10151 Uncharacterised conserved protein (DUF2359)<br>This is a 450 amino acid region of a family of proteins conserved from insects to humans. The mouse protein, Q8BM55, is annotated as being a putative Vitamin K-dependent carboxylation gamma-carboxyglutamic (GLA) domain containing protein, but this could not be confirmed. The function is not known.. 
+PF10152 Predicted coiled-coil domain-containing protein (DUF2360)<br>This is the conserved 140 amino acid region of a family of proteins conserved from nematodes to humans. One C. elegans member is annotated as a Daf-16-dependent longevity protein 1 but this could not be confirmed. The function is unknown.. 
+PF10153 Uncharacterised conserved protein (DUF2361)<br>This is a region of 120 amino acids that is conserved in a family of proteins found from plants to fungi. The function is not known.. 
+PF10154 Uncharacterized conserved protein (DUF2362)<br>This is a family of proteins conserved from nematodes to humans. The function is not known.. 
+PF10155 Uncharacterized conserved protein (DUF2363)<br>This is a region of 120 amino acids of a family of proteins conserved from plants to humans.  The function is not known.. 
+PF10156 DUF2364; <br>Subunit 17 of Mediator complex. This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.. 
+PF10157 Uncharacterized conserved protein (DUF2365)<br>This is a family of conserved proteins found from nematodes to humans. The function is unknown.. 
+PF10158 Tumour suppressor protein<br>This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression  . The exact function is not known.. 
+PF10159 Kinase phosphorylation protein<br>This is a glycine-rich domain that is the most highly conserved region of a family of proteins that in vertebrates are associated with tumours in multiple myelomas. The region may contain phosphorylation sites for several protein kinases, as well as N-myristoylation sites and nuclear localisation signals, so it might act as a signal molecule in the nucleus  .. 
+PF10160 Tmem40; <br>Predicted membrane protein. This is a region of 280 amino acids from a group of proteins conserved from plants to humans. It is predicted to be a membrane protein but its function is otherwise unknown.. 
+PF10161 Putative mitochondrial precursor protein<br>This is a family of small conserved proteins found from nematodes to humans. The C-terminal region is rich in asparagine. Members are putatively assigned to be mitochondrial precursor proteins but this could not be confirmed.. 
+PF10162 G8 domain<br>This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.. 
+PF10163 Transcription factor e(y)2<br>EnY2 is a small transcription factor which is combined in a complex with the TAFII40 protein  . The protein is conserved from paramecium to humans.. 
+PF10164 Uncharacterized conserved protein (DUF2367)<br>This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. The function is unknown. Several members are putatively assigned as brain protein i3 but this was not validated.. 
+PF10165 Guanine nucleotide exchange factor synembryn<br>Ric8 is involved in the EGL-30 neurotransmitter signalling pathway  . It is a guanine nucleotide exchange factor   that regulates neurotransmitter secretion.. 
+PF10166 Uncharacterised conserved protein (DUF2368)<br>This family is conserved from nematodes to humans. The function is not known.. 
+PF10167 Uncharacterised conserved protein<br>This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteristic NEP sequence motif. The function is not known.. 
+PF10168 Nuclear pore component<br>Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain  . Nup88 is overexpressed in tumour cells  .. 
+PF10169 Learning-associated protein<br>This is a family of 121-amino acid secretory proteins. Laps functions in the regulation of neuronal cell adhesion and/or movement and synapse attachment  . Laps binds to the ApC/EBP (Aplysia CCAAT/enhancer binding protein) promoter and activates the transcription of ApC/EBP mRNA  .. 
+PF10170 Cysteine-rich domain<br>This is the N-terminal approximately 100 amino acids of a family of proteins found from nematodes to humans. It contains between six and eight highly conserved cysteine residues and a characteristic DPF sequence motif. One member is putatively named as receptor for egg jelly protein but this could not confirmed.. 
+PF10171 Uncharacterised conserved protein (DUF2366)<br>This is a family of proteins conserved from nematodes to humans. The function is not known.. 
+PF10172 Det1 complexing ubiquitin ligase<br>DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system  .. 
+PF10173 DUF2343;<br>Mitochondrial K+-H+ exchange-related. The members of this family function as mitochondrial potassium-hydrogen exchange transporters. The family is part of a large mitochondrial KHE protein complex.. 
+PF10174 RIM-binding protein of the cytomatrix active zone<br>This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion  . The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains  .. 
+PF10175 M-phase phosphoprotein 6<br>This is a family of M-phase phosphoprotein 6s which is necessary for generation of the 3' end of the 5.8S rRNA precursor. It preferentially binds to poly(C) and poly(U).. 
+PF10176 Protein of unknown function (DUF2370)<br>This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.. 
+PF10177 Uncharacterised conserved protein (DUF2371)<br>This is a family of proteins conserved from nematodes to humans. The function is not known.. 
+PF10178 Uncharacterised conserved protein (DUF2372)<br>This family consists of proteins found from plants to humans. The function is not known.. 
+PF10179 Uncharacterised conserved protein (DUF2369)<br>This is a proline-rich region of a group of proteins found from plants to fungi. The function is not known.. 
+PF10180 Uncharacterised conserved protein (DUF2373)<br>This is the C-terminal conserved region of a family of proteins found from fungi to humans. The function is not known.. 
+PF10181 GPI-GlcNAc transferase complex, PIG-H component<br>PIG-H is a family of conserved proteins that complexes with three other proteins to form the GPI-GnT (glycosylphosphatidylinositol anchor biosynthesis transferase) complex. It appears to be a peripheral membrane protein facing the cytoplasm involved in the first step in GPI anchor formation.. 
+PF10182 Flo11 domain<br>Pfam-B_18862 (Release 22.0). This presumed domain is found at the N-terminus of the S. cerevisiae Flo11 protein. Flo11 is required for diploid pseudohyphal formation and haploid invasive growth. It belongs to a family of proteins involved in invasive growth, cell-cell adhesion, and mating, many of which can substitute for each other under abnormal conditions  .. 
+PF10183 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) <br>This subunit is part of the mitochondrial NADH:ubiquinone oxidoreductase (complex I). It carries mitochondrial import sequences  .. 
+PF10184 Uncharacterized conserved protein (DUF2358)<br>DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.. 
+PF10185 Chaperone for wingless signalling and trafficking of LDL receptor<br>Mesd is a family of highly conserved proteins found from nematodes to humans. The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs)  . The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation)  .. 
+PF10186 DUF2355;<br>UV radiation resistance protein and autophagy-related subunit 14. KOGs (KOG4398), Wood V. The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway  . There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localisation of this complex at the PAS is controlled by Atg14  . Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex  .. 
+PF10187 N-terminal domain of NEFA-interacting nuclear protein NIP30<br>This is a the N-terminal 100 amino acids of a family of proteins conserved from plants to humans. The full-length protein has putatively been called NEFA-interacting nuclear protein NIP30, however no reference could be found to confirm this.. 
+PF10188 Organic solute transport protein 1<br>Oscp1 is a family of proteins conserved from plants to humans. It is called organic solute transport protein or oxido-red- nitro domain-containing protein 1, however no reference could be find to confirm the function of the protein.. 
+PF10189 Conserved protein (DUF2356)<br>This is a 200 amino acid region of a family of proteins conserved from plants to humans. Some members have been putatively annotated as being integrator complex subunit 3 but this could not be confirmed. The function is unknown.. 
+PF10190 Tmem170; <br>Putative transmembrane protein 170. Tmem170 is a family of putative transmembrane proteins conserved from nematodes to humans. The protein is only of approximately 130 amino acids in length. The function is unknown.. 
+PF10191 DUF2354; <br>Golgi complex component 7 (COG7). COG7 is a component of the conserved oligomeric Golgi complex which is required for normal Golgi morphology and localisation. Mutation in COG7 causes a congenital disorder of glycosylation  .. 
+PF10192 Rhodopsin-like GPCR transmembrane domain<br>This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers  .. 
+PF10193 Telomere length regulation protein<br>This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.. 
+PF10195 DNA-binding nuclear phosphoprotein p8<br>P8 is a short 80-82 amino acid protein that is conserved from nematodes to humans. It carries at least one protein kinase C domain suggesting a possible role in signal transduction and it is thought to be a phosphoprotein, but the sites of phosphorylation and the kinases involved remain to be determined  .. 
+PF10197 N-terminal domain of CBF1 interacting co-repressor CIR<br>This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex  .. 
+PF10198 Histone acetyltransferases subunit 3<br>Ada3 is a family of proteins conserved from yeasts to humans  . It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage  .. 
+PF10199 KYY; <br>Alpha and gamma adaptin binding protein p34. p34 is a protein involved in membrane trafficking.  It is known to interact with both alpha and gamma adaptin  .  It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane  .. 
+PF10200 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa<br>This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain  .. 
+PF10203 Cytochrome c oxidase assembly protein PET191<br>Pet191_N is the conserved N-terminal of a family of conserved proteins found from nematodes to humans. It carries six highly conserved cysteine residues. Pet191 is required for the assembly of active cytochrome c oxidase but does not form part of the final assembled complex  .. 
+PF10204 Dual oxidase maturation factor<br>DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases.  DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites  . It is conserved from nematodes to humans.. 
+PF10205 Predicted coiled-coil domain-containing protein<br>This is the N-terminal 100 amino acid domain of a family of proteins conserved from nematodes to humans. It carries a characteristic KLRAQ sequence-motif. The function is not known.. 
+PF10206 Mitochondrial F1F0-ATP synthase, subunit f<br>This is a family of small proteins of approximately 110 amino acids, which are highly conserved from nematodes to humans. Some members of the family have been annotated in Swiss-Prot as being the f subunit of mitochondrial F1F0-ATP synthase but this could not be confirmed. The sequence has a well-conserved WRW motif. The exact function of the protein is not known.. 
+PF10208 Degradation arginine-rich protein for mis-folding<br>This is a family of small proteins of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. Armet is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress  .. 
+PF10209 Uncharacterized conserved protein (DUF2340)<br>This is a family of small proteins of approximately 150 amino acids of unknown function.. 
+PF10210 Mitochondrial 28S ribosomal protein S32<br>This entry is of a family of short, approximately 100 amino acid residues, proteins which are mitochondrial 28S ribosomal proteins named as MRP-S32.\.   Their exact function could not be confirmed.. 
+PF10211 Axonemal dynein light chain<br>Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains  .. 
+PF10212 Predicted coiled-coil domain-containing protein<br>This is the C-terminal 500 amino acids of a family of proteins with a predicted coiled-coil domain conserved from nematodes to humans. It carries a characteristic TTKRSYEDQ sequence-motif. The function is not known.. 
+PF10213 Mitochondrial ribosomal subunit protein <br>This is a conserved region of approx. 125 residues of one of the proteins that makes up the small subunit of the mitochondrial ribosome. In Saccharomyces cerevisiae the protein is MRP-S24 whereas in humans it is MRP-S28. The human mitochondrial ribosome has 29 distinct proteins in the small subunit and these have homologues in, for example, Drosophila melanogaster, Caenorhabditis elegans, and in the genomes of several fungi  .. 
+PF10214 RNA polymerase I-specific transcription-initiation factor<br>RNA polymerase I-specific transcription-initiation factor Rrn6 and Rrn7 represent components of a multisubunit transcription factor essential for the initiation of rDNA transcription by Pol I  . These proteins are found in fungi.. 
+PF10215 Oligosaccaryltransferase  <br>Ost4 is a very short, approximately 30 residues, enzyme found from fungi to vertebrates. It is a member of the ER oligosaccaryltansferase complex, EC 2.4.1.119, that catalyses the asparagine-linked glycosylation of proteins. It appears to be an integral membrane protein that mediates the en bloc transfer of a preassembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum (RER).. 
+PF10216 CO2 hydration protein (ChpXY)<br>This small family of proteins includes paralogues ChpX and ChpY in Synechococcus sp. PCC7942 and other cyanobacteria, associated with distinct NAD(P)H dehydrogenase complexes. These proteins collectively enable light-dependent CO2 hydration and CO2 uptake; loss of both blocks growth at low CO2 concentrations.. 
+PF10217 Uncharacterized conserved protein (DUF2039)<br>This entry is a region of approximately 100 residues containing three pairs of cysteine residues. The region is conserved from plants to humans but its function is unknown.. 
+PF10218 Uncharacterized conserved protein (DUF2054)<br>This entry contains 14 conserved cysteines, three of which are CC-dimers. The region is of approximately 200 residues in length but its function is unknown.. 
+PF10220 Uncharacterized conserved protein (DUF2146)<br>This is a family of proteins conserved from plants to humans. In Dictyostelium it is annotated as Mss11p but this could not be confirmed. Mss11p is required for the activation of pseudo-hyphal and invasive growth by Ste12p in yeast.. 
+PF10221 Cell cycle and development regulator<br>This is a set of proteins conserved from worms to humans. The proteins are a PAN GU kinase substrate, Mat89Bb, essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.. 
+PF10222 Uncharacterized conserved protein (DUF2152)<br>This is a family of proteins conserved from worms to humans. Its function is unknown.. 
+PF10223 Uncharacterized conserved protein (DUF2181)<br>This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.. 
+PF10224 Predicted coiled-coil protein (DUF2205)<br>This entry represent a highly conserved 100 residue region which is likely to be a coiled-coil structure. The exact function is unknown.. 
+PF10225 Uncharacterized conserved protein (DUF2215)<br>This entry is the central 200 residues of a family of proteins conserved from worms to humans. The function is unknown.. 
+PF10226 Uncharacterized conserved proteins (DUF2216)<br>This is the conserved N-terminal half of a proteins which are found from worms to humans. some annotation suggests it might be PKR, the Hepatitis delta antigen-interacting protein A, but this could not be confirmed.. 
+PF10228 Uncharacterised conserved protein (DUF2228)<br>This is a family of conserved proteins of approximately 700 residues found from worms to humans.. 
+PF10229 Uncharacterized conserved protein (DUF2246)<br>This is a family of proteins conserved from worms to humans of approximately 300 residues. The function is unknown.. 
+PF10230 Uncharacterised conserved protein (DUF2305)<br>This family of proteins is conserved from plants to humans. The function is unknown.. 
+PF10231 Uncharacterised conserved protein (DUF2315)<br>This is a family of small conserved proteins found from worms to humans. The function is not known.. 
+PF10232 Arc32; <br>Mediator of RNA polymerase II transcription complex subunit 8. Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex  . The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20  .. 
+PF10233 Uncharacterized conserved protein CG6151-P<br>This is a family of small, less than 200 residue long, proteins which are named as CG6151-P proteins that are conserved from fungi to humans. The function is unknown.  The fungal members have a characteristic ICP sequence motif. Some members are annotated as putative clathrin-coated vesicle protein but this could not be defined.. 
+PF10234 Clusterin-associated protein-1<br>This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell  .. 
+PF10235 Microtubule-associated protein CRIPT<br>The CRIPT protein is a cytoskeletal protein involved in microtubule production. The C-terminal domain is essential for binding to the PDZ3 domain of the SAP90 protein, one of a super-family of PDZ-containing proteins that play an important role in coupling the membrane ion channels with their signalling partners.  SAP90 is concentrated in the post synaptic density of glutamatergic neurons  .. 
+PF10236 Mitochondrial ribosomal death-associated protein 3<br>This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis  . DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix   and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).. 
+PF10237 DPPF;<br>Probable N6-adenine methyltransferase. This is a protein of approximately 200 residues which is conserved from plants to humans  .  It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteristic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes  .. 
+PF10238 E2F-associated phosphoprotein<br>This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis  .. 
+PF10239 FAM98AB; <br>Protein of unknown function (DUF2465). FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.. 
+PF10240 Fam125A; <br>Protein of unknown function (DUF2464). This is a family of proteins conserved from worms to humans. Members have been annotated as FAM125A proteins, but their function is unknown.. 
+PF10241 Uncharacterized conserved protein<br>This is a family of short proteins which are conserved over a region of 80 residues.  There is a characteristic KxDL motif towards the C-terminus.  The function is unknown.. 
+PF10242 Lipoma HMGIC fusion partner-like protein<br>This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans   and hypospadias  , and LHFPL1 is transcribed in six liver tumour cell lines  .. 
+PF10243 Microtubule-binding protein MIP-T3<br>This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3.  The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved  .. 
+PF10244 Mitochondrial ribosomal subunit<br>MRP-L51 is a family of small proteins from the intact 55 S mitochondrial ribosome  . It has otherwise been referred to as bMRP-64  . The exact function of this family is not known.. 
+PF10245 Mitochondrial 28S ribosomal protein S22<br>This is the conserved N-terminus and central portion of the mitochondrial small subunit 28S ribosomal protein S22.  Mammalian mitochondria carry out the synthesis of 13 polypeptides that are essential for oxidative phosphorylation and, hence, for the synthesis of the majority of the ATP used by eukaryotic organisms. The number of proteins produced by prokaryotes is smaller, reflected in the lower number of ribosomal proteins present in them  .. 
+PF10246 Mitochondrial ribosomal protein MRP-S35<br>This is a family of short mitochondrial ribosomal proteins, less than 200 amino acids long. that are highly conserved from worms to humans. The structure has previously been referred to as MRP-S18 but the current numbering fits the preferred nomenclature from these authors.. 
+PF10247 Mit_gmP; <br>Reactive mitochondrial oxygen species modulator 1. This is a family of small, approximately 100 amino acid, proteins found from yeasts to humans. The majority of endogenous reactive oxygen species (ROS) in cells are produced by the mitochondrial respiratory chain. An increase or imbalance in ROS alters the intracellular redox homeostasis, triggers DNA damage, and may contribute to cancer development and progression  . Members of this family are mitochondrial reactive oxygen species modulator 1 (Romo1) proteins that are responsible for increasing the level of ROS in cells. Increased Romo1 expression can have a number of other effects including: inducing premature senescence of cultured human fibroblasts [2,3] and increased resistance to 5-fluorouracil  .. 
+PF10248 Myelodysplasia-myeloid leukemia factor 1-interacting protein<br>This entry is the conserved central region of a group of proteins that are putative transcriptional repressors  . The structure contains a putative 14-3-3 binding motif involved in the subcellular localisation of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila  . Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions  .. 
+PF10249 NADH-ubiquinone oxidoreductase subunit 10<br>NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.. 
+PF10250 GDP-fucose protein O-fucosyltransferase<br>This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese  .. 
+PF10251 Presenilin enhancer-2 subunit of gamma secretase<br>This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyses the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex  .. 
+PF10252 Casein kinase substrate phosphoprotein PP28<br>This domain is a region of 70 residues conserved in proteins from plants to humans and contains a serine/arginine rich motif. In rats the full protein is a casein kinase substrate, and this region contains phosphorylation sites for both cAMP-dependent protein kinase and casein kinase II  .. 
+PF10253 PRCC_Cterm;<br>Mitotic checkpoint regulator, MAD2B-interacting. This family constitutes the major, conserved, portion of PRCC proteins. In humans this family interacts with MAD2B, the mitotic checkpoint protein [1,2].\.      In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing  .. 
+PF10254 PACS-1 cytosolic sorting protein<br>PACS-1 is a cytosolic sorting protein that directs the localisation of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef  .. 
+PF10255 RNA polymerase I-associated factor PAF67<br>RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67  . This family of proteins is conserved from worms to humans.. 
+PF10256 QRDY; <br>Golgin subfamily A member 7/ERF4 family. KOGs (KOG4069 & KOG4101). This family of proteins includes Golgin subfamily A member 7 proteins as well as Ras modification protein ERF4.. 
+PF10257 Retinoic acid induced 16-like protein<br>This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.. 
+PF10258 PHAX RNA-binding domain<br>RNA_GG_bind is the highly conserved U3 snoRNA-binding domain of PHAX (phosphorylated adaptor for RNA export) whose function is to transport U3 snoRNA from the nucleus after transcription  . It is characterised by having two pairs of adjacent glycines, as GGx12GG.. 
+PF10259 Rogdi leucine zipper containing protein<br>This is a family of conserved proteins which have been suggested as containing leucine-zipper domains. A leucine zipper domain is a region of 30 amino acids with leucines repeating every seven or eight residues; these proteins do have many such leucines. The protein in Drosophila comes from the gene ROGDI.. 
+PF10260 Uncharacterized conserved domain (SAYSvFN)<br>This domain of approximately 75 residues contains a highly conserved SATSv/iFN motif. The function is unknown but the domain is conserved from plants to humans.. 
+PF10261 Inositol phospholipid synthesis and fat-storage-inducing TM<br>This is a family of transmembrane proteins which are variously annotated as possibly being inositol phospholipid synthesis protein   and fat-storage-inducing. The members are conserved from yeasts to humans and are localised to the endoplasmic reticulum where they are involved in triglyceride lipid droplet formation  .. 
+PF10262 SelT; <br>KOGs (KOG3286) & COG3526. This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding  . Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown  . Selenoprotein W contains selenium as selenocysteine  in the primary protein structure and levels of this  selenoprotein are affected by selenium  .. 
+PF10263 SprT-like family<br>This family represents a domain found in eukaryotes and prokaryotes.  The domain contains a characteristic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.. 
+PF10264 Winged helix Storkhead-box1 domain<br>This is the conserved N-terminal winged helix domain of Storkhead-box1 protein which is likely to be a DNA binding domain. In humans the full-length protein controls polyploidization of extravillus trophoblast and is implicated in pre-eclampsia.. 
+PF10265 Uncharacterized conserved protein (DUF2217)<br>This is a family of conserved proteins of from 500 - 600 residues found from worms to humans. Its function is not known.. 
+PF10266 Hereditary spastic paraplegia protein strumpellin<br>This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteristic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies.. 
+PF10267 Tmcc1; Transmemb_cc2; Tmemcc2; <br>Predicted transmembrane and coiled-coil 2 protein. This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.. 
+PF10268 Tmem161AB; Transmemb_161AB; Tmem161AB; <br>Predicted transmembrane protein 161AB. Transmemb_161AB is a family of conserved proteins found from worms to humans. Members are putative transmembrane proteins but otherwise the function is not known.. 
+PF10269 Tmem185A; <br>Transmembrane Fragile-X-F protein . This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B  .. 
+PF10270 Tmem32; Tmemb_32;<br>Membrane magnesium transporter. This entry represents a novel family of membrane magnesium transporters (MMgT)  . The proteins, MMgT1 and MMgT2, are localised to the Golgi complex and post-Golgi vesicles, including the early endosomes, suggesting that they may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells  .. 
+PF10271 Putative transmembrane protein<br>This is a family of conserved proteins found from worms to humans. They are putative transmembrane proteins but the function is unknown.. 
+PF10272 Putative transmembrane protein precursor<br>This is a family of proteins conserved from worms to humans. The proteins are purported to be transmembrane protein-precursors but the function is unknown.. 
+PF10273 Pre-rRNA-processing protein TSR2<br>This entry represents the central conserved section of a family of proteins described as pre-rRNA-processing protein TSR2. The region has a distinctive WGG motif but the function is unknown.. 
+PF10274 Parkin co-regulated protein<br>This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system  .  Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.. 
+PF10275 Otubain; <br>Peptidase C65 Otubain. This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.. 
+PF10276 Zinc-finger domain<br>This is a short zinc-finger domain conserved from fungi to humans. It is Cx8Hx14Cx2C.. 
+PF10277 Frag1/DRAM/Sfk1 family<br>KOGs (KOG3979) & KOGs (KOG4320) & Pfam-B_15139 (release 21.0). This family includes Frag1, DRAM and Sfk1 proteins.  Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans.  There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function  .  Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced  .  This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton [3-4].. 
+PF10278 Mediator of RNA pol II transcription subunit 19 <br>Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators  .. 
+PF10279 Latarcin precursor<br>This family represents the precursor proteins for a number of short antimicrobial peptides called Latarcins. Latarcins were discovered in the venom of the spider Lachesana tarabaevi  . Latarcins are likely to adopt amphipathic alpha-helical structure in the plasma membrane.. 
+PF10280 HSPC296_Med11; <br>Mediator complex protein . Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organisation is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans  . Med11 appears to be necessary for the full and successful assembly of the core head sub-region  .. 
+PF10281 Putative stress-responsive nuclear envelope protein<br>Pfam-B_11056 (release 21.0). This family of proteins found in fungi is a putative stress-responsive nuclear envelope protein Ish1  .. 
+PF10282 DUF2394; Muc_lac_enz;<br>Lactonase, 7-bladed beta-propeller. Pfam-B_1372 (release 21.0). This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway.\.     Structures of proteins in this family have revealed a 7-bladed beta-propeller fold  .. 
+PF10283 Zinc-finger (CX5CX6HX5H) motif<br>Pfam-B_93850 (release 21.0). This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.. 
+PF10284 Luciferase helical bundle domain<br>This domain is found associated with the the catalytic domain of dinoflagellate luciferase . Luciferase is involved in catalysing the light emitting reaction in bioluminescence. The structure of this domain has been solved  . This domain has a three helix bundle structure that holds four important histidines that are thought to play a role in the pH regulation of the enzyme.. 
+PF10285 Luciferase catalytic domain<br>This domain is the catalytic domain of dinoflagellate luciferase . Luciferase is involved in catalysing the light emitting reaction in bioluminescence. The structure of this domain has been solved  . The core part of the domain is a 10 stranded beta barrel that is structurally similar to lipocalins and FABP  .. 
+PF10287 Putative TOS1-like glycosyl hydrolase (DUF2401)<br>Pfam-B_11571 (release 21.0). This family of proteins is conserved in fungi. One member is annotated putatively as OPEL, a house-keeping protein, but this could not be confirmed. It contains 5 highly conserved cysteines two of which form a characteristic CGC sequence motif. It has recently been shown that this family is related to known glycosyl hydrolases  .. 
+PF10288 Protein of unknown function (DUF2392)<br>Pfam-B_10085 (release 21.0). This is a family of proteins conserved from plants to humans. The function is not known.  It carries a characteristic GRG sequence motif.. 
+PF10290 Glycine-rich protein domain (DUF2403)<br>Pfam-B_11570 (release 21.0). This domain is found in the N-terminal region of members of DUF2401 Pfam:PF10287. The function of this glycine-rich region is unknown.. 
+PF10291 SAFF;<br>Muniscin C-terminal mu homology domain. Yang H, Pfam-B_7632 (release 21.0). The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.. 
+PF10292 Srab; <br>Serpentine type 7TM GPCR receptor class ab chemoreceptor. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  . The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organisms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells  .. 
+PF10293 Domain of unknown function (DUF2405)<br>Pfam-B_12420 (release 21.0). This is a conserved region of a family of proteins conserved in fungi. The function is unknown.. 
+PF10294 Putative methyltransferase<br>Pfam-B_19672 (Release 21.0). 
+PF10295 Uncharacterised protein (DUF2406)<br>Pfam-B_13850 (release 21.0). This is a family of small proteins conserved in fungi. The function is not known.. 
+PF10296 Putative integral membrane protein conserved region (DUF2404)<br>Pfam-B_12178 (release 21.0). This domain is conserved from plants to humans. The function is not known.. 
+PF10297 Minimal binding motif of Hap4 for binding to Hap2/3/5   <br>In Saccharomyces cerevisiae, the haem-activated protein complex Hap2/3/4/5 plays a major role in the transcription of genes involved in respiration  . Hap4_Hap_bind is the essential domain of Hap4 which allows it to associate with Hap2, Hap3 and Hap5 to form the Hap complex  .. 
+PF10298 WhiA N-terminal LAGLIDADG-like domain<br>This domain is found at the N terminal of sporulation factor WhiA. This domain is related to the LAGLIDADG Homing endonuclease domain while the C terminal domain of WhiA is predicted to be a DNA binding helix-turn-helix domain  .. 
+PF10300 Deme6; IML2;<br>Protein of unknown function (DUF3808). Pfam-B_15386 (release 21.0). This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain Pfam:PF07719 at their C-terminus.. 
+PF10302 DUF2407 ubiquitin-like domain<br>Pfam-B_17915 (release 21.0). This is a family of proteins found in fungi. The function is not known. This domain is related to the ubiquitin domain.. 
+PF10303 Protein of unknown function (DUF2408)<br>Pfam-B_16841 (release 21.0). This is a family of proteins conserved in fungi. The function is unknown.. 
+PF10304 Domain of unknown function (DUF2411)<br>Pfam-B_15078 (release 21.0). This is a 38 residue domain that is found in proteins at the extreme C-terminal end of some HEAT repeats Pfam: PF02985. the function of this domain is not known.. 
+PF10305 RNA pol II promoter Fmp27 protein domain<br>Pfam-B_15444 (release 21.0). Fmp27_SW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation  . It contains characteristic SW and GKG sequence motifs.. 
+PF10306 Hypothetical protein FLILHELTA<br>Pfam-B_18082 (release 21.0). This is a family of conserved proteins found in fungi. It contains a characteristic FL(I)LHE(L)TA sequence motif, where the bracketed residues are I, L or V. The function is not known.. 
+PF10307 Hypothetical protein (DUF2410)<br>Pfam-B_19378 (release 21.0). This is a family of proteins conserved in fungi. The function is not known.There are two characteristic sequence motifs, GGWW and TGR.. 
+PF10309 Protein of unknown function (DUF2414)<br>Pfam-B_22455 (release 21.0). This is a family of proteins conserved from fungi to mammals. One mouse member is referred to as ELG protein but this is not a homologue of human ELG protein.  The function is not known.. 
+PF10310 Protein of unknown function (DUF2413)<br>Pfam-B_20450 (release 21.0). This is a family of proteins conserved in fungi.  The function is not known.. 
+PF10311 Increased loss of mitochondrial DNA protein 1<br>Pfam-B_22448 (release 21.0). This is a family of proteins of approximately 200 residues that are conserved in fungi. Ilm1 is part of the peroxisome, a complex that is the sole site of beta-oxidation in Saccharomyces cerevisiae and known to be required for optimal growth in the presence of fatty acid. Ilm1 may participate in the control of the C16/C18 ratio since it interacts strongly with Mga2p, a transcription factor that controls expression of Ole1, the sole fatty acyl desaturase in S. cerevisiae responsible for conversion of the saturated fatty acids stearate (C18) and palmitate (C16) to oleate and palmitoleate, respectively  .. 
+PF10312 Conserved mid region of cactin<br>Pfam-B_20647 (release 21.0). This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus Pfam:PF09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localisation signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo  .. 
+PF10313 Uncharacterised protein domain (DUF2415)<br>Pfam-B_25751 (release 21.0). This is a short, 30 residue domain, from a family of proteins conserved in fungi. The function is unknown. There is a characteristic DLL sequence motif.. 
+PF10315 Protein of unknown function (DUF2416)<br>Pfam-B_28778 (release 21.0). This is a family of conserved proteins found in fungi. The function is not known.. 
+PF10316 Srbc; <br>Serpentine type 7TM GPCR chemoreceptor Srbc . Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10317 Srd; <br>Serpentine type 7TM GPCR chemoreceptor Srd. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10318 Srh; <br>Serpentine type 7TM GPCR chemoreceptor Srh. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srh is part of the Str superfamily of chemoreceptors  . Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10319 Srj; <br>Serpentine type 7TM GPCR chemoreceptor Srj. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily  . Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10320 Srsx; <br>Serpentine type 7TM GPCR chemoreceptor Srsx. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10321 Srt; <br>Serpentine type 7TM GPCR chemoreceptor Srt. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10322 Sru; <br>Serpentine type 7TM GPCR chemoreceptor Sru. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Sru is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10323 Srv; <br>Serpentine type 7TM GPCR chemoreceptor Srv. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srv is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10324 Srw; <br>Serpentine type 7TM GPCR chemoreceptor Srw. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  . The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz  .. 
+PF10325 Srz; <br>Serpentine type 7TM GPCR chemoreceptor Srz. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  . The genes encoding Srz appear to be under strong adaptive evolutionary pressure  .. 
+PF10326 Str; <br>Serpentine type 7TM GPCR chemoreceptor Str. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split  .  Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10327 Serpentine_Sri; <br>Serpentine type 7TM GPCR chemoreceptor Sri. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10328 Serpentine_Srx; <br>Serpentine type 7TM GPCR chemoreceptor Srx. Thomas JH, Robertson H. Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type  . Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'  .. 
+PF10329 Region of unknown function (DUF2417)<br>Pfam-B_22799 (release 21.0). This is a region of a family of proteins conserved in fungi some of whose members also have the Abhydrolase_1, Pfam:PF00561, domain in their sequence. The function of this region is not known.. 
+PF10330 Putative Sin3 binding protein<br>Pfam-B_24989 (release 21.0). This is a family of the conserved N-terminal end of a group of proteins conserved in fungi. It is likely to be a Sin3 binding protein. Sin3p does not bind DNA directly even though the yeast SIN3 gene functions as a transcriptional repressor. Sin3p is part of a large multiprotein complex  . Stb3 appears to bind directly to ribosomal RNA Processing Elements (RRPE) although there are no obvious domains which would accord with this, implying that Stb3 may be a novel RNA-binding protein  .. 
+PF10332 Protein of unknown function (DUF2418)<br>Pfam-B_29723 (release 21.0). This is a conserved 100 residue central region of a family of proteins found in fungi. It carries a characteristic EYD sequence motif. The function is not known.. 
+PF10333 GPI-Mannosyltransferase II co-activator<br>Pfam-B_50403 (release 21.0). Pga1 is found only in yeasts and not in mammals. It localises in the ER as a glycosylated integral membrane protein. It binds to the GPI-mannosyltransferase II subunit of the GPI and it is responsible for the second mannose addition to GPI precursors. The GPI-anchoring complex is a glycolipid that functions as a membrane anchor for many cell-surface proteins  .. 
+PF10334 Protein of unknown function (DUF2421)<br>Pfam-B_39020 (release 21.0). This is a family of proteins conserved in fungi. The function is not known.. 
+PF10335 Putative nucleotidyltransferase substrate binding domain<br>This domain is found associated with presumed nucleotidyltransferase domains and seems to be distantly related to other helical substrate binding domains.. 
+PF10336 Protein of unknown function (DUF2420)<br>Pfam-B_32350 (release 21.0). This is a family of proteins conserved in fungi.  The function is not known.. 
+PF10337 Protein of unknown function (DUF2422)<br>Pfam-B_42729 (release 21.0). This is a family of proteins conserved in fungi. The function is not known. This family is the C-terminal half of some member proteins which contain the DUF2421 Pfam:PF10334 domain at their N-terminus.. 
+PF10338 Protein of unknown function (DUF2423)<br>Pfam-B_46946 (release 21.0). This is a family of proteins conserved in fungi. The function is not known.. 
+PF10339 Yeast-specific zinc responsive<br>Pfam-B_50673 (release 21.0). This is a small family of proteins from Saccharomyces and related species. The function is not known but member proteins are highly induced in zinc-depleted conditions [1,2] and have increased expression in NAP1-deletion mutants  . The S. cerevisiae genes are named VEL by association with Velum formation in the wine making process http://www.ajevonline.org/content/48/1/55.abstract. 
+PF10340 Protein of unknown function (DUF2424)<br>Pfam-B_51256 (release 21.0). This is a family of proteins conserved in yeasts. The function is not known.. 
+PF10341 Est3;<br>Shelterin complex subunit, TPP1/ACD. TPP1 is a component of the telomerase holoenzyme, involved in telomere replication.  It has been demonstrated that TPP1 dimerises and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes [1,2]. Yeast telomerase protein TPP1 (Est3 in yeast) is a novel type of GTPase  . The key residues in Swiss:Q03096 are an Asp at residue 86 and the Arg at residue 110.  The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TINF2, whereas the C-terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex  .  The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres [5,6]. This domain is conserved from fungi to mammals, hence family Telomere_Pot1 has been merged into the family  . The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear protein 2 (TIN2), TIN2-interacting protein 1 (TPP1) and protection of telomeres 1 (POT1)  .. 
+PF10342 Drmip_Hesp; Drmip_MAPK;<br>Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family. Pfam-B_42324 (release 21.0). Some members of this family appear to be serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. In A. fumigatus these proteins play a role in fungal cell wall organisation. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organisms as it interacts with MAPK. The family is also found in archaea and bacteria.. 
+PF10343 Protein of unknown function (DUF2419)<br>Pfam-B_35257 (release 21.0). This is a family of conserved proteins found from plants to humans. The function is not known. A few members are annotated as being cobyrinic acid a,c-diamide synthetase but this could not be confirmed.. 
+PF10344 DUF2425; <br>Mitochondrial protein from FMP27. Pfam-B_54917 (release 21.0). This family contains mitochondrial FMP27 proteins which in yeasts together with SEN1 are long genes that exist in a looped conformation, effectively bringing together their promoter and terminator regions. Pol-II is located at both ends of FMP27 when this gene is transcribed from a GAL1 promoter under induced and non-induced conditions  . The exact function of the Fmp27 protein is not certain.. 
+PF10345 Cohesin loading factor<br>Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4  .. 
+PF10346 Conidiation protein 6<br>Pfam-B_35316 (release 21.0). Con-6 is the conserved N-terminal region of a family of small proteins found in fungi  . It is expressed at approximately 6 hours after the induction of development and is induced just prior to major constriction-chain growth  .. 
+PF10347 RNA pol II promoter Fmp27 protein domain<br>Pfam-B_5282 (release 21.0). Fmp27_GFWDK is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation  . It contains characteristic GFWDK sequence motifs. Some members are associated with domain Fmp27_SW (Pfam:PF10305) towards the N terminus.. 
+PF10348 Domain of unknown function (DUF2427)<br>Pfam-B_52268 (release 21.0). This is the N-terminal region of a family of proteins conserved in fungi.  Several members are annotated as being Ftp1 but this could not be confirmed. The function is not known.. 
+PF10349 WW-domain ligand protein<br>Pfam-B_5077 (release 21.0). The WWbp domain is characterised by several short PY and PT-like motifs of the PPPPY form. These appear to bind directly to the WW domains of WWP1 and WWP2 and other such diverse proteins as dystrophin and YAP (Yes-associated protein). This is the WW-domain binding protein WWbp via PY and PY_like motifs. The presence of a phosphotyrosine residue in the pWBP-1 peptide abolishes WW domain binding which suggests a potential regulatory role for tyrosine phosphorylation in modulating WW domain-ligand interactions.  Given the likelihood that WWP1 and WWP2 function as E3 ubiquitin-protein ligases, it is possible that initial substrate-specific recognition occurs via WW domain-substrate protein interaction followed by ubiquitin transfer and subsequent proteolysis  . This domain lies just downstream of the GRAM (Pfam:PF02893) in many members.. 
+PF10350 Putative death-receptor fusion protein (DUF2428)<br>Pfam-B_6748 (release 21.0). This is a family of proteins conserved from plants to humans. The function is not known. Several members have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these could be confirmed.. 
+PF10351 Golgi-body localisation protein domain<br>Pfam-B_6317 (release 21.0). This is the C-terminus of a family of proteins conserved from plants to humans.  The plant members are localised to the Golgi proteins and appear to regulate membrane trafficking, as they are required for rapid vesicle accumulation at the tip of the pollen tube  . The C-terminus probably contains the Golgi localisation signal and it is well-conserved.. 
+PF10353 Protein of unknown function (DUF2430)<br>Pfam-B_67886 (release 21.0). This is a family of short, 111 residue, proteins found in S. pombe.  The function is not known.. 
+PF10354 Domain of unknown function (DUF2431)<br>Pfam-B_6967 (release 21.0). This is the N-terminal domain of a family of proteins found from plants to humans. The function is not known.. 
+PF10355 Protein of unknown function (Ytp1)<br>Pfam-B_7247 (release 21.0). This is a family of proteins found in fungi. The region appears to contain regions similar to mitochondrial electron transport proteins.  The C-terminal domain is hydrophobic and negatively charged. There are consensus sites for both N-linked glycosylation and cAMP-dependent protein kinase phosphorylation  .. 
+PF10356 Protein of unknown function (DUF2034)<br>This protein is expressed in fungi but its function is unknown.. 
+PF10357 Domain of Kin17 curved DNA-binding protein<br>Pfam-B_7469 (release 21.0). Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle  .. 
+PF10358 Eeig1;<br>N-terminal C2 in EEIG1 and EHBP1 proteins. Wood V, Coggill PC, Zhang D, Aravind L. Pfam-B_7857 (release 21.0). This version of the C2 domain was initally identified in the  vertebrate estrogen early-induced gene 1 (EEIG1)  , and its Drosophila ortholog required for uptake of dsRNA via  the endocytotic machinery to induce RNAi silencing  .  It is also in C.elegans ortholog Sym-3  (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1  (EH domain Binding Protein-1) that regulates endocytotic recycling  and two plant proteins, RPG that regulates Rhizobium-directed polar  growth and PMI1 (Plastid Movement Impaired 1) that is essential for  intracellular movement of chloroplasts in response to blue light  . . 
+PF10359 RNA pol II promoter Fmp27 protein domain<br>Pfam-B_8838 (release 21.0). Fmp27_WPPW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation  . It contains characteristic HQR and WPPW sequence motifs. and is towards the C-terminal in members which contain Fmp27_SW Pfam:PF10305.. 
+PF10360 Protein of unknown function (DUF2433)<br>Pfam-B_83000 (release 21.0). This is a conserved 120 residue region of a family of proteins found in fungi. The function is not known.. 
+PF10361 Protein of unknown function (DUF2434)<br>Pfam-B_84994 (release 21.0). This is a family of proteins conserved in fungi.  The function is not known.. 
+PF10363 DUF2435; Pmp3;<br>Protein of unknown function (DUF2435). Pfam-B_7476 (release 21.0). This is a conserved region of approximately 400 residues which is found only in eukaryotes. It is associated with HEAT domains Pfam:PF02985 in all members. The function is not known.. 
+PF10364 Putative capsular polysaccharide synthesis protein<br>Pfam-B_99492 (release 21.0). Found only in Vibrio species, pombe and one other fungi, this is a the N-terminal 150 residues of a family of proteins of unknown function.\.    There is a characteristic NKWYS sequence motif.. 
+PF10365 Domain of unknown function (DUF2436)<br>Pfam-B_5683 (Release 22.0). This domain is found on peptidase C25 proteins and has no known function.. 
+PF10366 Vacuolar sorting protein 39 domain 1<br>This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex  .  Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole  .  In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange  .  The precise function of this domain has not been characterised.. 
+PF10367 Vacuolar sorting protein 39 domain 2<br>This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex  .  Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole  .  In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange  .  This domain is involved in localisation and in mediating the interactions of Vps39 with Vps11  .. 
+PF10368 Putative cell-wall binding lipoprotein<br>YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity  .. 
+PF10369 Small subunit of acetolactate synthase<br>ALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase.  Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in branched-chain amino acid biosynthesis. This reaction is sensitive to certain herbicides  .. 
+PF10370 Domain of unknown function (DUF2437)<br>This is the N-terminal 50 amino acids of a group of bacterial proteins annotated as fumarylacetoacetate hydrolase-containing enzymes. In most cases members are associated with FAA_hydrolase Pfam:PF01557 further towards the C-terminus.. 
+PF10371 Domain of unknown function<br>EKR is a short, 33 residue, domain found in bacterial and some lower eukaryotic species which lies between a POR (pyruvate ferredoxin/flavodoxin oxidoreductase) Pfam:PF01558 and the 4Fe-4S binding domain Fer4 Pfam:PF00037. It contains a characteristic EKR sequence motif. The exact function of this domain is not known.. 
+PF10372 Bacterial membrane-spanning protein N-terminus<br>YojJ is the N-terminus of a family of bacterial proteins some of which are associated with DUF147 Pfam:PF02457 towards the C-terminus. It is a putative membrane-spanning protein.. 
+PF10373 Est1 DNA/RNA binding domain<br>Pfam-B_24280 (release 22.0). Est1 is a protein which recruits or activates telomerase at the site of polymerisation   . This is the DNA/RNA binding domain of EST1   .. 
+PF10374 Telomerase activating protein Est1<br>Pfam-B_39673 (release 22.0). Est1 is a protein which recruits or activates telomerase at the site of polymerisation   .. 
+PF10375 GRIP-related Arf-binding domain <br>The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localised to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane  .. 
+PF10376 Double-strand recombination repair protein  <br>Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.. 
+PF10377 Autophagy-related protein 11<br>Pfam-B_21462 (release 21.0). The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex [1,2]. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy  .. 
+PF10378 RMM; <br>Putative RRM domain  . Griffiths-Jones S, Coggill PC. This is a putative RRM, RNA-binding, domain found only in fungi. It occurs in proteins annotated as Nrd1 yeast proteins, which are known to carry RRM domains.  It is not homologous with any of the other RRM domains, eg RRM_1 Pfam:PF00076.. 
+PF10379 Virulence protein nec1<br>Mistry J, Morningstar A. Pfam-B_11405 (release 21.0). This is a family of virulence proteins that are found in pathogenic Streptomyces species.. 
+PF10380 Transcription factor CRF1<br>Pfam-B_25525 (release 21.0). CRF1 is a transcription factor that co-represses ribosomal genes with FHL1 via the TOR signalling pathway and protein kinase A  .. 
+PF10381 Autophagocytosis associated protein C-terminal<br>Pfam-B_10019 (release 7.3). Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The small C-terminal domain is likely to be a distinct binding region for the stability of the autophagosome complex  . It carries a highly characteristic conserved FLKF sequence motif.. 
+PF10382 Protein of unknown function (DUF2439)<br>Pfam-B_19050 (release 22.0). Proteins in this family have been implicated in telomere maintenance in Saccharomyces cerevisiae   and in meiotic chromosome segregation in Schizosaccharomyces pombe  . 
+PF10383 Transcription-silencing protein Clr2   <br>Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organisation at the cnt domain, the site of kinetochore assembly.. 
+PF10384 Centromere protein Scm3<br>Pfam-B_19394 (release 21.0). Scm3 is a centromere protein that has been shown in Saccharomyces cerevisiae to be required for G2/M progression and Cse4 localisation  .  The C terminal region of Scm3 proteins is variable in size and sometimes consists of DNA binding motifs  .. 
+PF10385 RNA polymerase beta subunit external 1 domain<br>RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region  .. 
+PF10386 Protein of unknown function (DUF2441)<br>This is a family of highly conserved, predicted, proteins from Bacillus species. The structure forms a homo-dimer. The function is unknown.. 
+PF10387 Protein of unknown function (DUF2442)<br>Gene3D, pdb_2auw & Pfam-B_2245 (release 23.0). This family of bacterial and fungal proteins has several members annotated as being putative molybdopterin-guanine dinucleotide biosynthesis protein A; however this could not be verified. Hence the function is not known.  This family also includes the DUF3532 that was found to be related and was merged into this family. Members of this family also fall into the NE0471 N-terminal domain-like superfamily, a family of proteins with a unique fold in SCOP:143880.. 
+PF10388 EAL-domain associated signalling protein domain<br>In Bacillus species this highly conserved region of the YkuI protein lies immediately downstream of the EAL (diguanylate cyclase/phosphodiesterase domain 2) Pfam:PF00563 domain so that together they form a monomer which dimerises for its enzymatic action. The region contains three alpha helices and five beta strands and is the C-terminal half of the structure.. 
+PF10389 Bacteriophage coat protein B <br>CoatB is a single filamentous bacteriophage alpha helix of approximately 44 residues. It is likely to assemble into a complex of 35 monomers in a Catherine-wheel like formation  . It is the major coat protein of the virion.. 
+PF10390 RNA polymerase II elongation factor ELL  <br>ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF  . Some members carry an Occludin domain Pfam:PF07303 just downstream. There is no S. cerevisiae member.. 
+PF10391 Fingers domain of DNA polymerase lambda<br>DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone  .. 
+PF10392 Golgi transport complex subunit 5<br>Pfam-B_24958 (release 21.0). The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.. 
+PF10393 Trimeric coiled-coil oligomerisation domain of matrilin<br>This short domain is a coiled coil structure and has a single cysteine residue at the start which is likely to form a di-sulfide bridge with a corresponding cysteine in an upstream EGF (Pfam:PF00008) domain thereby spanning a VWA (Pfam:PF00092) domain. All three domains can be associated together as in the cartilage matrix protein matrilin, where this domain is likely to be responsible for oligomerisation  .. 
+PF10394 Histone acetyl transferase HAT1 N-terminus<br>This domain is the N-terminal half of the structure of histone acetyl transferase HAT1. It is often found in association with the C-terminal part of the GNAT Acetyltransf_1 (Pfam:PF00583) domain. It seems to be motifs C and D of the structure. Histone acetyltransferases (HATs) catalyse the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. HATs are involved in transcription since histones tend to be hyper-acetylated in actively transcribed regions of chromatin, whereas in transcriptionally silent regions histones are hypo-acetylated  .. 
+PF10395 Utp8 family<br>Pfam-B_24590 (release 22.0). Utp8 is an essential component of the nuclear tRNA export machinery in Saccharomyces cerevisiae.  It is a tRNA binding protein that acts at a step between tRNA maturation /aminoacylation, and translocation of the tRNA across the nuclear pore complex  .. 
+PF10396 GTP-binding protein TrmE N-terminus<br>This family represents the shorter, B, chain of the homo-dimeric structure which is a guanine nucleotide-binding protein that binds and hydrolyses GTP.  TrmE is homologous to the tetrahydrofolate-binding domain of N,N-dimethylglycine oxidase and indeed binds formyl-tetrahydrofolate. TrmE actively participates in the formylation reaction of uridine and regulates the ensuing hydrogenation reaction of a Schiff's base intermediate.  This B chain is the N-terminal portion of the protein consisting of five beta-strands and three alpha helices and is necessary for mediating dimer formation within the protein  .. 
+PF10397 Adenylosuccinate lyase C-terminus<br>This is the C-terminal seven alpha helices of the structure whose full length represents the enzyme adenylosuccinate lyase. This sequence lies C-terminal to the conserved motif necessary for beta-elimination reactions  , Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole-carboxamide ribotide into aminoimidazole-carboxamide ribotide, the eighth step of the de novo pathway, and the formation of adenosine monophosphate (AMP) from adenylosuccinate, the second step in the conversion of inosine monophosphate into AMP  .. 
+PF10398 Protein of unknown function (DUF2443)<br>This is a small family of highly conserved proteins from bacteria, in particular Helicobacter species, The structure is a bundle of alpha helices. The function is not known.. 
+PF10399 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal<br>This is the N-terminal region of the E or R chain, Ubiquitinol-cytochrome C reductase Fe-S subunit, of the hetero-hexameric cytochrome bc1 complex. This region is a TAT-signal region. The cytochrome bc1 complex is an oligomeric membrane protein complex that is a component of respiratory and photosynthetic electron transfer chains.\.   The enzyme couples the transfer of electrons from ubiquinol to cytochrome c with the the generation of a protein gradient across the membrane  . The motif is also associated with Rieske (Pfam:PF00355), UCR_TM (Pfam:PF02921) and Ubiq-Cytc-red_N (Pfam:PF09165).. 
+PF10400 Virulence activator alpha C-term<br>This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (Pfam:PF03551), which is a transcriptional regulator.. 
+PF10401 Interferon-regulatory factor 3<br>This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein.  These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).\.   Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.. 
+PF10403 Rad4 beta-hairpin domain 1<br>This short domain is found in the Rad4 protein. This domain binds to DNA  .. 
+PF10404 Rad4 beta-hairpin domain 2<br>This short domain is found in the Rad4 protein. This domain binds to DNA  .. 
+PF10405 Rad4 beta-hairpin domain 3<br>This short domain is found in the Rad4 protein. This domain binds to DNA  .. 
+PF10406 Transcription factor TFIID complex subunit 8 C-term <br>This is the C-terminal, Delta, part of the TAF8 protein  . The N-terminal is generally the histone fold domain, Bromo_TP (Pfam:PF07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery  .. 
+PF10407 Cdc14 phosphatase binding protein N-terminus   <br>Wood V, Pfam-B_23062 (release 22.0). Cytokinesis in yeasts involves a family of proteins whose essential function is to bind Cdc14-family phosphatase and prevent this from being sequestered and inhibited in the nucleolus. This is the highly conserved N-terminus of a family of proteins which act as cytokinesis checkpoint controls by allowing cells to cope with cytokinesis defects. These proteins are required for rDNA silencing and mini-chromosome maintenance  .. 
+PF10408 Ubiquitin elongating factor core<br>Wood V, Pfam-B_4085 (release 22.0). This is the most conserved part of the core region of Ufd2P ubiquitin elongating factor or E4, running from helix alpha-11 to alpha-38. It consists of 31 helices of variable length connected by loops of variable size forming a compact unit; the helical packing pattern of the compact unit consists of five structural repeats that resemble tandem Armadillo (ARM) repeats. This domain is involved in ubiquitination as it binds Cdc48p and escorts ubiquitinated proteins from Cdc48p to the proteasome for degradation. The core is structurally similar to the nuclear transporter protein importin-alpha. The core is associated with the U-box at the C-terminus, Pfam:PF04564, which has ligase activity.. 
+PF10409 C2 domain of PTEN tumour-suppressor protein<br>This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding.  This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam:PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane  .. 
+PF10410 DnaB-helicase binding domain of primase<br>This domain is the C-terminal region three-helical domain of primase  . Primases synthesise short RNA strands on single-stranded DNA templates, thereby generating the hybrid duplexes required for the initiation of synthesis by DNA polymerases.  Primases are recruited to single-stranded DNA by helicases, and this domain is the region of the primase which binds DnaB-helicase  . It is associated with the Toprim domain (Pfam:PF01751) which is the central catalytic core.. 
+PF10411 Disulfide bond isomerase protein N-terminus<br>This is the N-terminal domain of the disulfide bond isomerase DsbC. The whole molecule is V-shaped, where each arm is a DsbC monomer of two domains linked by a hinge; and the N-termini of each monomer join to form the dimer interface at the base of the V, so are vital for dimerisation  . DsbC is required for disulfide bond formation and functions as a disulfide bond isomerase during oxidative protein-folding in bacterial periplasm. It also has chaperone activity  .. 
+PF10412 Type IV secretion-system coupling protein DNA-binding domain<br>The plasmid conjugative coupling protein TrwB forms hexamers from six structurally very similar protomers  . This hexamer contains a central channel running from the cytosolic pole (made up by the AADs) to the membrane pole ending at the transmembrane pore shaped by 12 transmembrane helices, rendering an overall mushroom-like structure. The TrwB_AAD (all-alpha domain) domain appears to be the DNA-binding domain of the structure. TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein, is the structural prototype for the type IV secretion system coupling proteins, a family of proteins essential for macromolecular transport between cells and export  .. 
+PF10413 Amino terminal of the G-protein receptor rhodopsin<br>Rhodopsin is the archetypal G-protein-coupled receptor. Such receptors participate in virtually all physiological processes, as signalling molecules. They utilise heterotrimeric guanosine triphosphate (GTP)-binding proteins to transduce extracellular signals to intracellular events.  Rhodopsin is important because of the pivotal role it plays in visual signal transduction. Rhodopsin is a dimeric transmembrane protein and its intradiskal surface consists of this amino terminal domain and three loops connecting six of the seven transmembrane helices. The N-terminus is a compact domain of alpha-helical regions with breaks and bends at proline residues outside the membrane  . The transmembrane part of rhodopsin is represented by 7tm_1 (Pfam:PF00001). The N-terminal domain is extracellular is and is necessary for successful dimerisation and molecular stability  .. 
+PF10414 Sirohaem synthase dimerisation region<br>Bacterial sulfur metabolism depends on the iron-containing porphinoid sirohaem. CysG, S-adenosyl-L-methionine (SAM)-dependent bis-methyltransferase, dehydrogenase and ferrochelatase, synthesises sirohaem from uroporphyrinogen III via reactions which encompass two branchpoint intermediates in tetrapyrrole biosynthesis, diverting flux first from protoporphyrin IX biosynthesis and then from cobalamin (vitamin B12) biosynthesis. CysG is a dimer of two structurally similar protomers held together asymmetrically through a number of salt-bridges across complementary residues in the CysG_dimeriser region to produce a series of active sites, accounting for CysG's multifunctionality, catalysing four diverse reactions: two SAM-dependent methylations, NAD+-dependent tetrapyrrole dehydrogenation and metal chelation. The CysG_dimeriser region holding the two protomers together is of 74 residues  .. 
+PF10415 Fumarase C C-terminus<br>Fumarase C catalyses the stereo-specific interconversion of fumarate to L-malate as part of the Kreb's cycle. The full-length protein forms a tetramer with visible globular shape. FumaraseC_C is the C-terminal 65 residues referred to as domain 3. The core of the molecule consists of a bundle of 20 alpha-helices from the five-helix bundle of domain 2. The projections from the core of the tetramer are generated from domains 1 and 3 of each subunit  . FumaraseC_C does not appear to be part of either the active site or the activation site but is helical in structure forming a little bundle.. 
+PF10416 Transcription-initiator DNA-binding domain IBD<br>In Trichomonas vaginalis, thought to be the earliest extant eukaryote, the sole initiator element for control of the start of transcription is Inr, and this is recognised by the initiator binding protein IBP39. IBP39 contains an N-terminal Inr binding domain, IBD, connected via a flexible, proteolytically sensitive, linker (residues 127-145) to a C-terminal domain. The IBD structure reveals a winged-helix-wing conformation with each element binding to DNA, the central helix-turn-helix contributing the majority of the specificity-determining contacts with the Inr core motif TCAPy(T/A). The binding of IBP39 to the Inr directly recruits RNA polymerase II and in this way initiates transcription  .. 
+PF10417 C-terminal domain of 1-Cys peroxiredoxin<br>This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols  . The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine, upstream of this domain; and glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulfide to the sulfhydryl and consequent activation of the enzyme  .  The domain is associated with family AhpC-TSA, Pfam:PF00578, which carries the catalytic cysteine.. 
+PF10418 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B<br>Lactococcus lactis is one of the few organisms with two dihydroorotate dehydrogenases, DHODs, A and B  . The B enzyme is a prototype for DHODs in Gram-positive bacteria that use NAD+ as the second substrate. DHODB is a hetero-tetramer composed of a central homodimer of PyrDB subunits resembling the DHODA structure and two PyrK subunits along with three different cofactors: FMN, FAD, and a [2Fe-2S] cluster. The [2Fe-2S] iron-sulfur cluster binds to this C-terminal domain of the PyrK subunit, which is at the interface between the flavin and NAD binding domains and contains three beta-strands. The four cysteine residues at the N-terminal part of this domain are the ones that bind, in pairs, to the iron-sulfur cluster. The conformation of the whole molecule means that the iron-sulfur cluster is localised in a well-ordered part of this domain close to the FAD binding site  . The FAD and and NAD binding domains are FAD_binding_6, Pfam:PF00970 and NAD_binding_1, Pfam:PF00175.. 
+PF10419 TFIIIC_subunit;<br>Pfam-B_14433 (release 21.0). This is a family of proteins subunits of TFIIIC  .  TFIIIC in yeast and humans is required for transcription of tRNA and 5 S RNA genes by RNA polymerase III.  Yeast members of this family are fused to phosphoglycerate mutase domain.. 
+PF10420 Cytokine interleukin-12p40 C-terminus<br>IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms  . This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40  . The domain is often associated with family fn3, Pfam:PF00041.. 
+PF10421 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus <br>This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end  . Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesise 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication  . This domain is often associated with NTP_transf_2 Pfam:PF01909.. 
+PF10422 Monopolin complex subunit LRS4<br>Pfam-B_63451 (release 22.0). Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae, that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I   . The orthologous complex in Schizosaccharomyces pombe is not required for meiosis I chromosome segregation, but is proposed to play a similar physiological role in clamping microtubule binding sites  .  In S .cerevisiae this subunit is called LRS4, and in S. pombe it is known as Mde4.. 
+PF10423 Bacterial AMP nucleoside phosphorylase N-terminus <br>This is the N-terminal domain of bacterial AMP nucleoside phosphorylase (AMNp). The N- and C-termini form distinct domains which intertwine with each other to form a stable monomer which associates with five other monomers to yield the active hexamer. The N-terminus consists of a long helix and a four-stranded sheet with a novel topology. The C-terminus binds the nucleoside whereas the N-terminus acts as the enzymatic regulatory domain. AMNp (EC:3.2.2.4) catalyses the hydrolysis of AMP to form adenine and ribose 5-phosphate. thereby regulating intracellular AMP levels  .. 
+PF10425 C-terminus of bacterial fibrinogen-binding adhesin<br>This is the C-terminal half of a bacterial fibrinogen-binding adhesin SdrG. SdrG is a Gram-positive cell-wall-anchored adhesin that allows attachment of the bacterium to host tissues via specific binding to the beta-chain of human fibrinogen (Fg). SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism which represents a general mode of ligand-binding for structurally related cell wall-anchored proteins in most Gram-positive bacteria. The C-terminal part of SdrG(276-596) is integral to the folding of the immunoglobulin-like whole to create the docking grooves necessary for Fg binding. The domain is associated with families of Cna_B, Pfam:PF05738  .. 
+PF10426 Recombination-activating protein 1 zinc-finger domain<br>This is a C2-H2 zinc-finger domain closely resembling the classical TFIIIA-type zinc-finger, CX3FX5LX2-3H, despite having a valine and a tyrosine at the core instead of a phenylalanine and a leucine, hence CX3VX1LX2YX2H.  The structure, nevertheless, contains the characteristic two-stranded beta-sheet and alpha-helix of a classical zinc-finger. The domain binds one zinc and, in complex with the zinc-RING-finger domain, helps to stabilise the whole of the dimerisation region of recombination activating protein 1 (RAG1)  . The function of the whole is to bind double-stranded DNA.. 
+PF10427 Argonaute hook<br>This region has been called the argonaute hook  . It has been shown to bind to the Piwi domain Pfam:PF02171 of Argnonaute proteins.. 
+PF10428 RAM signalling pathway protein<br>Pfam-B_35594 (release 22.0). SOG2 proteins in Saccharomyces cerevisiae are involved in cell separation and cytokinesis  .. 
+PF10429 Nuclear pore RNA shuttling protein Mtr2<br>Mtr2 is a monomeric, dual-action, RNA-shuttle protein found in yeasts. Transport across the nuclear-cytoplasmic membrane is via the macro-molecular membrane-spanning nuclear pore complex, NPC. The pore is lined by a subset of NPC members called nucleoporins that present FG (Phe-Gly) receptors, characteristically GLFG and FXFG motifs, for shuttling RNAs and proteins. RNA cargo is bound to soluble transport proteins (nuclear export factors) such as Mex67 in yeasts, and TAP in metazoa, which pass along the pore by binding to successive FG receptors. Mtr2 when bound to Mex67 maximises this FG-binding. Mtr2 also acts independently of Mex67 in transporting the large ribosomal RNA subunit through the pore  .. 
+PF10430 Tie-2 Ig-like domain 1<br>
+PF10431 C-terminal, D2-small domain, of ClpB protein <br>This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA, Pfam:PF00004) it lacks the long coiled-coil insertion, and instead of helix C4 contains a beta-strand (e3) that is part of a three stranded beta-pleated sheet. In Thermophilus the whole protein forms a hexamer with the D1-small and D2-small domains located on the outside of the hexamer, with the long coiled-coil being exposed on the surface. The D2-small domain is essential for oligomerisation, forming a tight interface with the D2-large domain of a neighbouring subunit and thereby providing enough binding energy to stabilise the functional assembly  . The domain is associated with two Clp_N, Pfam:PF02861, at the N-terminus as well as AAA, Pfam:PF00004 and AAA_2, Pfam:PF07724.. 
+PF10432 Bacterial phospho-glucose isomerase C-terminal region<br>This is the C-terminal half of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologues to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate  . It is associated with family SIS, Pfam:PF01380.. 
+PF10433 MMS1;<br>Mono-functional DNA-alkylating methyl methanesulfonate N-term. Pfam-B_64607 (release 22.0). MMS1 is a protein that protects against replication-dependent DNA damage in Saccharomyces cerevisiae  . MMS1 belongs to the DDB1 family of cullin 4 adaptors and the two proteins are homologous. MMS1 bridges the interaction of MMS22 and Crt10 with Cul8/Rtt101  .  Cul8/Rtt101 is a cullin protein involved in the regulation of DNA replication subsequent to DNA damage.  The N-terminal region of MMS1 and the C-terminal of MMS22 are required for the the MMS1-MMS22 interaction  . The human HIV-1 virion-associated protein Vpr assembles with DDB1 through interaction with DCAF1 (chromatin assembly factor) to form an E3 ubiquitin ligase that targets cellular substrates for proteasome-mediated degradation and subsequent G2 arrest  .. 
+PF10434 Monopolin complex protein MAM1<br>Pfam-B_58835 (release 22.0). Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae, that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I   . MAM1 is required in S. cerevisiae for monopolar attachment  .. 
+PF10435 Beta-galactosidase, domain 2<br>This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain is made up of 16 antiparallel beta-strands and an alpha-helix at its C terminus. The fold of this domain appears to be unique.  In addition, the last seven strands of the domain form a subdomain with an immunoglobulin-like (I-type Ig) fold in which the first strand is divided between the two beta-sheets. In penicillin spp this strand is interrupted by a 12-residue insertion which forms an additional edge-strand to the second beta-sheet of the sub-domain. The remainder of the second domain forms a series of beta-hairpins at its N terminus, four strands of which are contiguous with part of the Ig-like sub-domain, forming in total a seven-stranded antiparallel beta-sheet. This domain is associated with family Glyco_hydro_35, Pfam:PF01301, which is N-terminal to it, but itself has no metazoan members.. 
+PF10436 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase<br>Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c Pfam:PF02518 which is towards the C-terminal.. 
+PF10437 Bacterial lipoate protein ligase C-terminus<br>This is the C-terminal domain of a bacterial lipoate protein ligase.  There is no conservation between this C-terminus and that of vertebrate lipoate protein ligase C-termini, but both are associated with the domain BPL_LipA_LipB Pfam:PF03099, further upstream.  This domain is required for adenylation of lipoic acid by lipoate protein ligases. The domain is not required for transfer of lipoic acid from the adenylate to the lipoyl domain. Upon adenylation, this domain rotates 180 degrees away from the active site cleft. Therefore, the domain does not interact with the lipoyl domain during transfer.. 
+PF10438 Cyclo-malto-dextrinase C-terminal domain<br>This domain is at the very C-terminus of cyclo-malto-dextrinase proteins and consists of 8 beta strands, is largely globular and appears to help stabilise the acitve sites created by upstream domains, Cyc-maltodext_N Pfam:PF09087, and Alpha-amylase Pfam:PF00128.  Cyclo-malto-dextrinases hydrolyse cyclodextrans to maltose and glucose and catalyse trans-glycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules.. 
+PF10439 Bacteriocin class II with double-glycine leader peptide<br>This is a family of bacteriocidal bacteriocins secreted by Streptococcal species in order to kill off closely-related competitor Gram-positives. The sequence includes the peptide precursor, this being cleaved off proteolytically at the double-glycine. The family does not carry the YGNGVXC motif characteristic of pediocin-like Bacteriocins, Bacteriocin_II Pfam:PF01721. The producer bacteria are protected from the effects of their own bacteriocins by production of a specific immunity protein which is co-transcribed with the genes encoding the bacteriocins, eg family EntA_Immun Pfam:PF08951. The bacteriocins are structurally more specific than their immunity-protein counterparts. Typically, production of the bacteriocin gene is from within an operon carrying up to 6 genes including a typical two-component regulatory system (R and H), a small peptide pheromone (C), and a dedicated ABC transporter (A and -B) as well as an immunity protein  . The ABC transporter is thought to recognise the N termini of both the pheromone and the bacteriocins and to transport these peptides across the cytoplasmic membrane, concurrent with cleavage at the conserved double-glycine motif. Cleaved extracellular C can then bind to the sensor kinase, H, resulting in activation of R and up-regulation of the entire gene cluster via binding to consensus sequences within each promoter  . It seems likely that this whole regulon is carried on a transmissible plasmid which is passed between closely related Firmicute species since many clinical isolates from different Firmicutes can produce at least two bacteriocins. and the same bacteriocins can be produced by different species.. 
+PF10440 Ubiquitin-binding WIYLD domain<br>This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues  . It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, Swiss:Q8W595, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase  .. 
+PF10441 Urb2/Npa2 family<br>Pfam-B_28626 (Release 22.0). This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis  .. 
+PF10442 FIST C domain<br>The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids  .. 
+PF10443 RNA12 protein<br>Pfam-B_18000 (Release 22.0). This family includes RNA12 from S. cerevisiae.  That protein contains an RRM domain.  This region is C-terminal to that and includes a P-loop motif suggesting this region binds to NTP. The RNA12 proteins is involved in pre-rRNA maturation  .. 
+PF10444 DUF2455;<br>Nbl1 / Borealin N terminal. Mistry J, Hartsuiker E, Wood V. Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation.  In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p.  In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles.  Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localisation, stability, integrity, and function  .  The N terminus of Borealin is homologous to Nbl1  .  This family contains both Nbl1, and the N terminal region of Borealin.. 
+PF10445 Protein of unknown function (DUF2456)<br>Hartsuiker E, Wood V, Mistry J. Pfam-B_97171 (release 22.0). This is a family of uncharacterised proteins.. 
+PF10446 Protein of unknown function (DUF2457)<br>Hartsuiker E, Wood V, Mistry J. This is a family of uncharacterised proteins.. 
+PF10447 Exosome component EXOSC1/CSL4<br>Pfam-B_6887 (release 22.0). This family of proteins are components of the exosome 3'->5' exoribonuclease complex.  The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions  .. 
+PF10448 POC1; <br>20S proteasome chaperone. Pfam-B_75798 (release 22.0). This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (DMP1 and DMP2) have been solved, and they closely resemble that of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them  .. 
+PF10450 POC4; <br>In yeast, POC1 is a chaperone of the 20S proteasome which functions in early 20S proteasome assembly.. 
+PF10451 Telomere regulation protein Stn1<br>Pfam-B_51291 (release 21.0). The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA.  Structural profiling has predicted an OB-fold  . This domain is the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution  .. 
+PF10452 TORC1 subunit TCO89<br>Pfam-B_61649 (release 22.0). TC089 is a component of the TORC1 complex.  TORC1 is responsible for a wide range of rapamycin-sensitive cellular activities.. 
+PF10453 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)<br>Proteins in this family have been implicated in the assembly of the large subunit of the ribosome   and in telomere maintenance  .  Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA   and is phosphorylated upon DNA damage  .. 
+PF10454 Protein of unknown function (DUF2458)<br>Hartsuiker H, Wood V, Mistry J. This a is family of uncharacterised proteins.. 
+PF10455 Bin/amphiphysin/Rvs domain for vesicular trafficking<br>Pfam-B_12557 (release 22.0). This Pfam entry includes proteins that are not matched by Pfam:PF03114.. 
+PF10456 WASP-binding domain of Sorting nexin protein<br>Pfam-B_43522 (release 20.0). The C-terminal region of the Sorting nexin group of proteins appears to carry a BAR-like (Bin/amphiphysin/Rvs) domain. This domain is very diverse and the similarities with other BAR domains are few. In the Sorting nexins it is associated with family PX, Pfam:PF00787.13, and in combination with PX appears to be necessary to bind WASP along with p85 to form a multimeric signalling complex  .. 
+PF10457 Cholesterol-capturing domain<br>Pfam-B_16187 (release 22.0). Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops  . The function of the domain is to capture cholesterol and pass it to the associated START domain Pfam:PF01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localisation of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins  .. 
+PF10458 Valyl tRNA synthetase tRNA binding arm<br>This domain is found at the C-terminus of Valyl tRNA synthetases.. 
+PF10459 Peptidase S46<br>Rawlings N, Mistry J. Dipeptidyl-peptidase 7 (DPP-7) is the best characterised member of this family.  It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.. 
+PF10460 Peptidase M30<br>Rawlings N, Mistry J. This family contains the metallopeptidase hyicolysin.  Hyicolysin has a zinc ion which is liganded by two histidine and one glutamate residue.. 
+PF10461 Peptidase S68<br>Rawlings N, Mistry J. This family of serine peptidases contains PIDD proteins.  PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'.  The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.. 
+PF10462 Peptidase M66<br>Rawlings N, Mistry J. This family of metallopeptidases contains StcE, a virulence factor found in Shiga toxigenic Escherichia coli organisms.  StcE peptidase cleaves C1 esterase inhibitor  .. 
+PF10463 Peptidase U49<br>Rawlings N, Mistry J. This family contains Lit peptidase from Escherichia coli. Lit protease functions in bacterial cell death in response to infection by bacteriophage T4. Following binding of Gol peptide to domains II and III of elongation factor Tu, the Lit peptidase cleaves domain I of the elongation factor. This prevents binding of guanine nucleotides, shuts down translation and leads to cell death.. 
+PF10464 Peptidase U40<br>Rawlings N, Mistry J. This family contains P5 murein endopeptidase from bacteriophage phi-6.  P5 murein endopeptidase has lytic activity against several gram-negative bacteria.  It is thought that the enzyme cleaves the cell wall peptide bridge formed by meso-2,6-diaminopimelic acid and D-Ala. 
+PF10465 Peptidase_I24; <br>PinA peptidase inhibitor . Rawlings N, Mistry J. PinA inhibits the endopeptidase La.  It binds to the La homotetramer but does not interfere with the ATP binding site or the active site of La.. 
+PF10466 Saccharopepsin inhibitor I34<br>The saccharopepsin inhibitor is highly specific for the aspartic peptidase saccharopepsin.\.     It is largely unstructured in the absence of saccharopepsin  , but in the presence, the inhibitor undergoes a conformation change forming an almost perfect alpha-helix from Asn2 to Met32 in the active site cleft of the peptidase.. 
+PF10467 Peptidase inhibitor clitocypin<br>Rawlings N, Mistry J. Clitocypin binds and inhibits cysteine proteinases.  It has no similarity to any other known cysteine proteinase inhibitors but bears some similarity to a lectin-like family of proteins from mushrooms  .. 
+PF10468 Carboxypeptidase inhibitor I68<br>Rawlings N, Mistry J. This is a family of tick carboxypetidase inhibitors.. 
+PF10469 AKAP7 2'5' RNA ligase-like domain<br>AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes  . AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein  . Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains Pfam:PF02834. Presumably this domain carried out some as yet unknown enzymatic function.. 
+PF10470 PKA-RI-RII subunit binding domain of A-kinase anchor protein<br>AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP  . The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction  . The N-terminus, of family AKAP7_NLS, carries the nuclear localisation signal.. 
+PF10471 Anaphase-promoting complex APC subunit 1<br>The anaphase-promoting complex (APC) or cyclosome is a cell cycle-regulated ubiquitin-protein ligase that regulates important events in mitosis such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins thereby targeting them for proteolysis by the 26S proteasome. CDC26 is one of the nine or so subunits identified within APC but its exact function is not known  . The APC/C becomes active at the metaphase/anaphase transition and remains active during G1 phase. One mechanism linked to activation of the APC/C is phosphorylation.  The yeast APC/C is composed of at least 13 subunits, but the function of many of the subunits is unknown. Hcn1 is the smallest subunit of the S. pombe APC/C, and is found to be essential for cell viability, APC/C integrity, and proper APC/C regulation. In addition, Hcn1 phosphorylation indicates a specific role for the phosphorylation of this subunit late in the cell cycle  .. 
+PF10472 eIF2-alpha phosphatase phosphorylation constitutive repressor<br>This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation  . The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus  .. 
+PF10473 Cenp-F_leu_zip;<br>Leucine-rich repeats of kinetochore protein Cenp-F/LEK1. Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [1,2]. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to be binding DNA directly in this instance  .. 
+PF10474 Protein of unknown function C-terminus (DUF2451)<br>This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2450.. 
+PF10475 Protein of unknown function N-terminal domain (DUF2450)  <br>This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2451.. 
+PF10476 Protein of unknown function C-terminus (DUF2448) <br>The family DUF2349 is the N-terminal part of this family. This protein is found in eukaryotes but its function is not known.. 
+PF10477 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E<br>EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localisation signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation  .. 
+PF10479 Fragile site-associated protein C-terminus<br>This is the conserved C-terminal half of the protein KIAA1109 which is the fragile site-associated protein FSA  . Genome-wide-association studies showed this protein to linked to the susceptibility to coeliac disease  . The protein may also be associated with polycystic kidney disease  .. 
+PF10480 Beta-1 integrin binding protein<br>ICAP-1 is a serine/threonine-rich protein that binds to the cytoplasmic domains of beta-1 integrins in a highly specific manner, binding to a NPXY sequence motif on the beta-1 integrin. The cytoplasmic domains of integrins are essential for cell adhesion, and the fact that phosphorylation of ICAP-1 by interaction with the cell-matrix implies an important role of ICAP-1 during integrin-dependent cell adhesion  . Overexpression of ICAP-1 strongly reduces the integrin-mediated cell spreading on extracellular matrix and inhibits both Cdc42 and Rac1. In addition, ICAP-1 induces release of Cdc42 from cellular membranes and prevents the dissociation of GDP from this GTPase  . An additional function of ICAP-1 is to promote differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state  ,. 
+PF10481 Cenp-F_N;<br>Cenp-F N-terminal domain. Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore  . Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein  .. 
+PF10482 Tumour-suppressor protein CtIP N-terminal domain<br>CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control  . This N-terminal domain carries a coiled-coil region and is essential for homodimerisation of the protein  . The C-terminal domain is family Pfam:PF08573.. 
+PF10483 Hap2_elong;<br>Elongator subunit Iki1. Coggill P, Eberhardt R. Pfam-B_26773 (release 22.0). This family is a component of the RNA polymerase II elongator complex [1,2]. This complex is involved in elongation of RNA polymerase II transcription and in modification of wobble nucleosides in tRNA [3,4].. 
+PF10484 Mitochondrial ribosomal protein S23<br>MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs  . All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system  . MRP-S23 is significantly up-regulated in uterine cancer cells  .. 
+PF10486 DUF2447; <br>Phosphoinositide 3-kinase gamma adapter protein p101 subunit. Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits  .. 
+PF10487 Nucleoporin subcomplex protein binding to Pom34<br>This is one of the many peptides that make up the nucleoporin complex (NPC), and is found across eukaryotes  . The Nup188 subcomplex (Nic96p-Nup188p-Nup192p-Pom152p) is one of at least six that make up the NPC, and as such is symmetrically localised on both faces of the NPC at the nuclear end, being integrally bound to the C-terminus of Pom34p  .. 
+PF10488 Phosphatase-1 catalytic subunit binding region<br>This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels  .. 
+PF10489 Ret finger protein-like 3 antisense<br>This short transcript is purported to be the antisense protein of exon 2 of RFPL3 gene, however this was not confirmed. Since the RFPL3 (ret-finger protein-like 3) gene is expressed in testis the suggestion is that this may have a role in the antisense regulation of the RFPL genes. RFPL transcripts encode proteins with tripartite structure of RING finger, coiled-coil, and B30-2 domains, which are characteristic of the RING-B30 family. Each of these domains is thought to mediate protein-protein interactions by promoting homo- or heterodimerisation  .. 
+PF10490 Rb-bdg_C_Cenp-F;<br>Rb-binding domain of kinetochore protein Cenp-F/LEK1. Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [1,2]. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains  .. 
+PF10491 NLS-binding and DNA-binding and dimerisation domains of Nrf1<br>In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human  . Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila  . The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity  .. 
+PF10492 Nrf1 activator activation site binding domain<br>In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human  . Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila  . The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss:Q8C4C0, there is an activation domain at 303-469, the most conserved part of which is this domain 446-469.  Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity  . The family Nrf1_DNA-bind is associated with this domain towards the N-terminal, as is the N terminal of the activation domain.. 
+PF10493 Rough deal protein C-terminal region<br>Buljan M,, Coggill P. Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localising first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10  , and indeed the two proteins function together, localisation of each depending upon the other  . These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase . The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint  .. 
+PF10494 Serine-threonine protein kinase 19<br>This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP  .. 
+PF10495 Pericentrin-AKAP-450 domain of centrosomal targeting protein<br>This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly  .. 
+PF10496 SNARE-complex protein Syntaxin-18 N-terminus <br>This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates  . More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes  .. 
+PF10497 Zinc-finger domain of monoamine-oxidase A repressor R1<br>R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type  .. 
+PF10498 Intra-flagellar transport protein 57  <br>Eukaryotic cilia and flagella are specialised organelles found at the periphery of cells of diverse organisms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated  . This protein is known as Huntington-interacting protein-1 in humans.. 
+PF10500 Nuclear RNA-splicing-associated protein<br>SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing  . SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway  .. 
+PF10501 Ribosomal_S39; <br>Ribosomal subunit 39S. The 39S ribosomal protein appears to be a subunit of one of the larger mitochondrial 66S or 70S units  . Under conditions of ethanol-stress in rats the larger subunit is largely dissociated into its smaller components  . In E. coli, in the absence of the enzyme pseudouridine synthase (RluD) synthase, there is an accumulation of 50S and 30S subunits and the appearance of abnormal particles (62S and 39S), with concomitant loss of 70S ribosomes  .. 
+PF10502 Signal peptidase, peptidase S26 <br>Mistry J. Rawlings N. This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesised secreted proteins.  Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.. 
+PF10503 Esterase PHB depolymerase<br>Mistry J, Fushinobu S. This family of proteins include acetyl xylan esterases (AXE), feruloyl esterases (FAE), and poly(3-hydroxybutyrate) (PHB) depolymerases.. 
+PF10504 Protein of unknown function (DUF2452)<br>This protein is found in eukaryotes but its function is unknown.. 
+PF10505 NMDA receptor-regulated gene protein 2 C-terminus<br>Buljan M, Coggill P, Berhardt R. The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2.  NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse , six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi  . This C-terminal domain belongs to the PD-(D/E)XK nuclease superfamily  .. 
+PF10506 PDZ domain of MCC-2 bdg protein for Usher syndrome<br>The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.. 
+PF10507 Protein of unknown function (DUF2453)<br>Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.. 
+PF10508 Proteasom_PSMB5; <br>Proteasome non-ATPase 26S subunit. The 26S proteasome, a eukaryotic ATP-dependent, dumb-bell shaped, protease complex with a molecular mass of approx 20kDa consists of a central 20S proteasome,functioning as a catalytic machine, and two large V-shaped terminal modules, having possible regulatory roles,composed of multiple subunits of 25- 110 kDa attached to the central portion in opposite orientations. It is responsible for degradation of abnormal intracellular proteins, including oxidatively damaged proteins, and may play a role as a component of a cellular anti-oxidative system. Expression of catalytic core subunits including PSMB5 and peptidase activities of the proteasome were elevated following incubation with 3-methylcholanthrene. The 20S proteasome comprises a cylindrical stack of four rings, two outer rings formed by seven alpha-subunits (alpha1-alpha7) and two inner rings of seven beta-subunits (beta1-beta7). Two outer rings of alpha subunits maintain structure, while the central beta rings contain the proteolytic active core subunits beta1 (PSMB6), beta2 (PSMB7), and beta5 (PSMB5). Expression of PSMB5 can be altered by chemical reactants, such as 3-methylcholanthrene  .. 
+PF10509 Galactokinase galactose-binding signature<br>PROSITE_PS00106, Pfam-B_2277 (release 22.0). This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry  . The function of this domain appears to be to bind galactose  , and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6  . This domain is associated with the families GHMP_kinases_C, Pfam:PF08544 and GHMP_kinases_N, Pfam:PF00288.. 
+PF10510 Phosphatidylinositol-glycan biosynthesis class S protein<br>PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI  . Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U.  The exact function of PIG-S is unclear  .. 
+PF10511 Trappin protein transglutaminase binding domain<br>Trappin-2, itself a protease inhibitor, has this unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase  . This domain contains several repeated motifs with the the consensus sequence Gly-Gln-Asp-Pro-Val-Lys, and these together can anchor the whole molecule to extracellular matrix proteins, such as laminin, fibronectin, beta-crystallin, collagen IV, fibrinogen, and elastin, by transglutaminase-catalysed cross-links. The whole domain is rich in glutamine and lysine, thus allowing and transglutaminase(s) to catalyse the formation of an intermolecular epsilon-(gamma-glutamyl)lysine isopeptide bond  . Cementoin is associated with the WAP family, Pfam:PF00095, at the C-terminus.. 
+PF10512 Cell division cycle-associated protein 8 <br>The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters  .. 
+PF10513 Enhancer of polycomb-like<br>Pfam-B_3033 (release 22.0). This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes  .. 
+PF10514 Pro-apoptotic Bcl-2 protein, BAD<br>BAD is a Bcl-2 homology domain 3 (BH3)-only pro-apoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors  . Binding of BAD to mitochondria is thought to be exclusively mediated by its BH3 domain. Membrane localisation of BAD mediates membrane translocation of Bcl-XL. The C-terminal part of BAD is sufficient for membrane binding. There are two segments with differing lipid-binding preferences, LBD1 and LBD2, that are responsible for this binding: (i) LBD1 located in the proximity of the BH3 domain (amino acids 122-131) and (ii) LBD2, the putative C-terminal alpha-helix-5  . Phosphorylation-regulated 14-3-3 protein binding may expose the cholesterol-preferring LBD1 and bury the LBD2, thereby mediating translocation of BAD to raft-like micro-domains  .. 
+PF10515 beta-amyloid precursor protein C-terminus<br>PROSITE_PS00320, Pfam-B_2082 (release 22.0). This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, Pfam:PF02177, further towards the N-terminus.. 
+PF10516 SHNi-TPR<br>Pfam-B_14727 (release 22.0). SHNi-TPR family members contain a reiterated sequence motif that is an interrupted form of TPR repeat  .. 
+PF10517 Electron transfer DM13<br>The DM13 domain is a component of a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins  .  It contains a nearly absolutely conserved cysteine, which could be involved in a redox reaction, either as a naked thiol group or through binding a prosthetic group like heme  .. 
+PF10518 TAT (twin-arginine translocation) pathway signal sequence<br>
+PF10520 Kua-ubiquitin conjugating enzyme hybrid localisation domain<br>
+PF10521 Protein of unknown function (DUF2454)<br>Pfam-B_82729 (release 22.0). A Schizosaccharomyces pombe member of this family is known to interact with Tel2.  Tel2 is a component of the TOR complexes  .. 
+PF10522 RII binding domain<br>Vijayaraghavan et al. Mol Endocrinology 13(5):705-717 (1999). This domain is found is a wide variety of AKAPs (A kinase anchoring proteins)  .. 
+PF10523 BEN domain<br>The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription  .. 
+PF10524 Nuclear factor I protein pre-N-terminus<br>The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organisms. The N-terminal 200 residues contains the DNA-binding and dimerisation domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerisation-ability and the stimulation of adenovirus DNA replication  .. 
+PF10525 Engrailed homeobox C-terminal signature domain<br>PROSITE_PS00033, Pfam-B_11539 (release 22.0). Engrailed homeobox proteins are characterised by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins  .. 
+PF10528 GLEYA domain<br>This presumed domain is found in fungal adhesins and is related to the PA14 domain.. 
+PF10529 Histidine-rich Calcium-binding repeat region<br>This is a histidine-rich calcium binding repeat which appears in proteins called histidine-rich-calcium binding proteins (HRC). HRC is a high capacity, low affinity Ca2+-binding protein, residing in the lumen of the sarcoplasmic reticulum. HRC binds directly to triadin. This binding interaction occurs between the histidine-rich region of HRC and multiple clusters of charged amino acids, named as the KEKE motifs, in the lumenal domain of triadin. The region in which this repeat is found in many copies is long and variable but is the acidic region of the protein. There is also a cysteine-rich region further towards the C-terminus  . HRC may regulate sarcoplasmic reticular calcium transport and play a critical role in maintaining calcium homeostasis and function in the heart. HRC as a candidate regulator of sarcoplasmic reticular calcium uptake  .. 
+PF10530 Toxin with inhibitor cystine knot ICK or Knottin scaffold<br>Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot (ICK) structural motif or Knottin scaffold. The four disulfide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7. CSTX-1 is the most important component of C. salei venom in terms of relative abundance and toxicity and therefore is likely to contribute significantly to the overall toxicity of the whole venom. CSTX-1 blocked rat neuronal L-type, but no other types of HVA Cav channels  . Interestingly, the omega-toxins from Phoneutria nigriventer venom (another South American species also belonging to the Ctenidae family) are included as they carry the same disulfide bond arrangement. suggested that CSTX-1 may interact with Cav channels. Calcium ion voltage channel heteromultimer containing an L-type pore-forming alpha1-subunit is the most probable candidate for the molecular target of CSTX-1 these toxins  .. 
+PF10531 SLBB domain<br>
+PF10532 Plant specific N-all beta domain<br>This domain was identified by Babu and colleagues  . It is found associated with the WRKY domain Pfam:PF03106.. 
+PF10533 Plant zinc cluster domain<br>This zinc binding domain was identified by Babu and colleagues and found associated with the WRKY domain Pfam:PF03106  .. 
+PF10534 Connector enhancer of kinase suppressor of ras<br>The CRIC - Connector enhancer of kinase suppressor of ras - domain functions as a scaffold in several signal cascades and acts on proliferation, differentiation and apoptosis.. 
+PF10536 Plant mobile domain<br>This domain was identified by Babu and colleagues in a variety of transposases  .. 
+PF10537 ATP-utilising chromatin assembly and remodelling N-terminal<br>ACF (for ATP-utilising chromatin assembly and remodelling factor) is a chromatin-remodelling complex that catalyses the ATP-dependent assembly of periodic nucleosome arrays. The WAC (WSTF/Acf1/cbp146) domain is an approximately 110-residue module present at the N-termini of Acf1-related proteins in a variety of organisms. The DNA-binding region of Acf1 includes the WAC domain, which is necessary for the efficient binding of ACF complex to DNA.. 
+PF10538 Immunoreceptor tyrosine-based activation motif<br>Signal transduction by T and B cell antigen receptors and certain receptors for Ig Fc regions involves a conserved sequence motif, termed an immunoreceptor tyrosine-based activation motif (ITAM). It is also found in the cytoplasmic domain of apoptosis receptor.. 
+PF10539 Development and cell death domain<br>The DCD domain is found in plant proteins involved in development and cell death. The DCD domain is an approximately 130 amino acid long stretch that contains several mostly invariable motifs. These include a FGLP and a LFL motif at the N-terminus and a PAQV and a PLxE motif towards the C-terminus of the domain. The DCD domain is present in proteins with different architectures. Some of these proteins contain additional recognisable motifs, like the KELCH repeats or the ParB domain.. 
+PF10540 Munc13 (mammalian uncoordinated) homology domain<br>Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical.. 
+PF10541 Nuclear envelope localisation domain<br>The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localisation domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes  . During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere  .  SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics  .. 
+PF10542 Vitelline membrane cysteine-rich region<br>In Drosophila melanogaster the vitelline membrane (VM) is the first layer of the eggshell produced by the follicular epithelium. It is composed of at least four different proteins. VM proteins are similarly organised with a central highly conserved 38-amino acid domain which is flanked by unrelated regions. The domain contains three highly conserved cysteines.. 
+PF10543 ORF6N domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10544 T5orf172 domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10545 Alcohol dehydrogenase transcription factor Myb/SANT-like<br>The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.. 
+PF10546 P63C domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10547 P22_AR N-terminal domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10548 P22AR C-terminal domain<br>This domain was identified by Iyer and colleagues  . It is found associated with Pfam:PF10547.. 
+PF10549 ORF11CD3 domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10550 Conantokin-G mollusc-toxin<br>The conantokins are a family of neuroactive peptides found in the venoms of fish-hunting cone snails. They possess a high content of gamma-carboxyglutamic acid (Gla) (4-5 residues), a non-standard amino-acid made by the post-translational modification of glutamate (Glu) residue. Conantokins are the only natural biochemically characterised peptides known to be N-methyl-D-aspartate (NMDA) receptor antagonists.. 
+PF10551 MULE transposase domain<br>This domain was identified by Babu and colleagues  .. 
+PF10552 ORF6C domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10553 MSV199 domain<br>This domain was identified by Iyer and colleagues  .. 
+PF10554 Ash protein family<br>This family was identified by Iyer and colleagues  . It includes the Ash protein from bacteriophage P4.. 
+PF10555 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 <br>Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (mraY) is a bacterial enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. It is an integral membrane protein with probably ten transmembrane domains. This domain is located at the end of the first cytoplasmic loop and the beginning of the second transmembrane domain.. 
+PF10557 Cullin protein neddylation domain<br>This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue  .. 
+PF10558 Mitochondrial 18 KDa protein (MTP18)  <br>This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis  . Overexpression studies suggest that MTP18 is required for mitochondrial fission  .. 
+PF10559 Plug_Sec61p; <br>Plug domain of Sec61p. The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74  .. 
+PF10561 Uncharacterised protein family UPF0565<br>This family of proteins has no known function.. 
+PF10562 Calmodulin-binding domain C0 of NMDA receptor NR1 subunit<br>Pfam-B_7118 (release 22.0). This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a critical role in learning, memory, neural development, and synaptic plasticity. Calmodulin (CaM) regulates NMDARs by binding tightly to the C0 and C1 regions of their NR1 subunit. The conserved tryptophan is considered to be the anchor residue  .. 
+PF10563 Cadmium carbonic anhydrase repeat<br>This domain is the cadmium carbonic anhydrase repeat unit of the beta-carbonic anhydrase of a marine diatom  , that uses both zinc and cadmium for catalysis of the reversible hydration of carbon dioxide for use in inorganic carbon acquisition for photosynthesis (thus being a cambialistic enzyme). Compared with alpha- and gamma-carbonic anhydrases that use three histidines to coordinate the zinc-atom, this beta-carbonic anhydrase has two cysteines and one histidine, and rapidly binds cadmium  .. 
+PF10564 Sialic-acid binding micronemal adhesive repeat<br>This domain is a novel carbohydrate-binding domain found on micronemal proteins. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Toxoplasma gondii can infect and replicate within all nucleated cells  . This domain interacts with sialylated oligosaccharides; the protein in Toxoplasma gondii is a monomer but several MAR domains are carried on the protein. Each MAR domain contains one central sialic acid-binding pocket  .. 
+PF10565 N-methyl D-aspartate receptor 2B3 C-terminus<br>Pfam-B_53396 (release 22.0). This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family Pfam:PF00060 further upstream as well as the ANF_receptor family Pfam:PF01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites  .. 
+PF10566 Glycoside hydrolase 97  <br>This domain is the catalytic region of the bacterial glycosyl-hydrolase family 97. This central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, form two additional non-catalytic domains  .  In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands [2,3].. 
+PF10567 RNA-recognition motif<br>Griffiths-Jones S, Coggill P. Pfam-B_57293 (release 21.0). This conserved domain is found in fungal proteins and appears to be involved in RNA-processing. It binds to poly-adenylated RNA, interacts genetically with mRNA 3'-end processing factors, copurifies with the nuclear cap-binding protein Cbp20p, and is found in complexes containing other translation factors, such as EIF4G as in Swiss:P39935 and Swiss:P39936.. 
+PF10568 Outer mitochondrial membrane transport complex protein<br>Pfam-B_30563 (release 22.0). The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane  . It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex  .. 
+PF10569 Alpha-macro-globulin thiol-ester bond-forming region<br>This short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.. 
+PF10570 Myelin-PO_N;<br>Myelin-PO cytoplasmic C-term p65 binding region. Pfam-B_1437 (release 22.0), PROSITE_PS00568. Myelin protein zero is the major myelin protein in the peripheral central nervous system and is essential for normal myelination. The family is a single-pass transmembrane molecule containing one Ig-like loop in the extracellular domain and this highly basic 69 residue C-terminal cytoplasmic domain which is the region that interacts with protein p65  .. 
+PF10571 Uncharacterised protein family UPF0547<br>This domain contains a zinc-ribbon motif.. 
+PF10572 Uncharacterised protein family UPF0556<br>This family of proteins has no known function.. 
+PF10573 Uncharacterised protein family UPF0561<br>This family of proteins has no known function.. 
+PF10574 Uncharacterised protein family UPF0552<br>This family of proteins has no known function.. 
+PF10576 Iron-sulfur binding domain of endonuclease III<br>Escherichia coli endonuclease III (EC 4.2.99.18)   is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidised pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand  . The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease  .. 
+PF10577 Uncharacterised protein family UPF0560<br>This family of proteins has no known function.. 
+PF10578 Seminal vesicle protein repeat<br>
+PF10579 Rapsyn N-terminal myristoylation and linker region<br>Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane  .. 
+PF10580 Gap junction protein N-terminal region<br>
+PF10581 Synapsin N-terminal<br>This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin  .. 
+PF10582 Gap junction channel protein cysteine-rich domain<br>Pfam-B_1437 (release 22.0), PROSITE_PS00408. 
+PF10583 Involucrin of squamous epithelia N-terminus<br>Pfam-B_7423 (release 22.0), PROSITE_PS00795. This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane  .\.   Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis  . The downstream part of the protein is represented by the family Involucrin, Pfam:PF00904.. 
+PF10584 Proteasome subunit A N-terminal signature<br>This domain is conserved in the A subunits of the proteasome complex proteins.. 
+PF10585 Ubiquitin-activating enzyme active site <br>Ubiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin-conjugating enzymes (E2)  . This domain carries the last of five conserved cysteines that is part of the active site of the enzyme, responsible for ubiquitin thiolester complex formation, the active site being represented by the sequence motif PICTLKNFP  .. 
+PF10587 Eukaryotic elongation factor 1 beta central acidic region<br>Pfam-B_9497 (release 22.0), PROSITE_PS00824. 
+PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region<br>Pfam-B_202 (release 22.0), PROSITE_PS00642. 
+PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region<br>Pfam-B_339 (release 22.0), PROSITE_PS00645. 
+PF10590 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region<br>Pfam-B_685 (release 22.0), PROSITE_PS01064. Pyridoxine 5'-phosphate oxidase (PNPOx) catalyses the terminal step in the biosynthesis of pyridoxal 5'-phosphate (PLP), a cofactor used by many enzymes involved in amino acid metabolism. The enzyme oxidises either the 4'-hydroxyl group of pyridoxine 5'-phosphate (PNP) or the 4'-primary amine of pyridoxamine 5'-phosphate (PMP) to an aldehyde. PNPOx is a homodimeric enzyme with one flavin mononucleotide (FMN) molecule non-covalently bound to each subunit. This domain represents one of the two dimerisation regions of the protein, located at the edge of the dimer interface, at the C-terminus, being the last three beta strands, S6, S7, and S8 along with the last three residues to the end. In Swiss:P21159, S6 runs from residues 178-192, S7 from 200-206 and S8 from 211-215. the extended loop, of residues 167-177 may well be involved in the pocket formed between the two dimers that positions the FMN molecule  .. 
+PF10591 Secreted protein acidic and rich in cysteine Ca binding region<br>Pfam-B_3882 (release 22.0), PROSITE_PS00613. The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2  .. 
+PF10592 AIPR protein<br>This family of proteins was identified in   as an abortive infection phage resistance protein often found in restriction modification system operons.. 
+PF10593 Z1 domain<br>This uncharacterised domain was identified by Iyer and colleagues  . It is found associated with a helicase domain of superfamily type II.. 
+PF10595 Uncharacterised protein family UPF0564<br>This family of proteins has no known function. However, one of the members, Swiss:Q22CP8, is annotated as an EF-hand family protein.. 
+PF10596 U6-snRNA interacting domain of PrP8<br>This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor  .. 
+PF10597 U5-snRNA binding site 2 of PrP8<br>The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis  . This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor  .. 
+PF10598 RNA recognition motif of the spliceosomal PrP8<br>The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa  . The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain  .. 
+PF10599 Retro-transposon transporting motif  <br>This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organisms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localisation signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity  .. 
+PF10600 PDZ-associated domain of NMDA receptors<br>Pfam-B_10923 (release 22.0). This domain is found in higher eukaryotes between the second and third PDZ domains, Pfam:PF00595, of glutamate receptor like proteins. Its exact function is not known.. 
+PF10601 LITAF-like zinc ribbon domain<br>Clustering of trematode sequences. Members of this family display a conserved zinc ribbon structure   with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS) . The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure  .. 
+PF10602 26S proteasome subunit RPN7<br>Pfam-B_4112 (release 22.0). RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity  .  The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.. 
+PF10604 Polyketide cyclase / dehydrase and lipid transport<br>Lakshminarayan L, Mistry J. This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily  .. 
+PF10605 3HB-oligomer hydrolase (3HBOH) <br>FIG094011 (Release 2.0). D-(-)-3-hydroxybutyrate oligomer hydrolase (also known as 3HB-oligomer hydrolase) functions in the degradation of poly-3-hydroxybutyrate (PHB).  It catalyses the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers.. 
+PF10606 Homer-binding domain of metabotropic glutamate receptor <br>Pfam-B_17370 (release 22.0). This is the proline-rich region of metabotropic glutamate receptor proteins that binds Homer-related synaptic proteins. The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich "Homer ligand" (PPXXFr). Activation of PI turnover triggers intracellular calcium release  . MGluR function is altered in the mouse model of human Fragile X syndrome mental retardation, a disorder caused by loss of function mutations in the Fragile X mental retardation gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners  .. 
+PF10607 RanBPM_CRA;<br>CTLH/CRA C-terminal to LisH motif domain. Pfam-B_3765 (release 22.0), UPF0559. RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.  This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined  . This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif  .. 
+PF10608 Polyubiquitination (PEST) N-terminal domain of MAGUK<br>Pfam-B_18049 (release 22.0). The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination  . PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerisation of the whole protein  .. 
+PF10609 ParA/MinD ATPase like<br>Pfam-B_177 (release 21.0). This family contains ATPases involved in plasmid partitioning  .  It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits  .. 
+PF10610 Thin aggregative fimbriae synthesis protein<br>FIGFAMs, Mistry J, Coggill P. FIG009025 (Release 2.0). Fimbriae are cell-surface protein polymers, of eg. E coli and Salmonella spp, that mediate interactions important for host and environmental persistence, development of biofilms, motility, colonisation and invasion of cells, and conjugation. Four general assembly pathways for different fimbriae have been proposed, one of which is extracellular nucleation-precipitation (ENP), that differs from the others in that fibre-growth occurs extracellularly. Thin aggregative fimbriae (Tafi) are the only fimbriae dependent on the ENP pathway. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. Tafi are known as curli because, in the absence of extracellular polysaccharides, their morphology appears curled; however, when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix. The gene agfC is found to be transcribed at low levels, localised to the periplasm in a mature form, and in combination with AgfE is important for AgfA extracellular assembly, which facilitates the synthesis of Tafi. The genes involved in Tafi production are organised into two adjacent divergently transcribed operons, agfBAC and agfDEFG, both of which are required for biosynthesis and assembly  .. 
+PF10611 Protein of unknown function (DUF2469)<br>FIG004032 (Release 2.0). Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.. 
+PF10612 Spore coat protein Z<br>FIGFAMs, Mistry J, Coggill P. FIG014057 (Release 2.0). This family has members annotated as Spore coat protein Z, otherwise known as CotZ, It is a cysteine-rich spore coat family, and along with CotY is necessary for assembly of intact exosporium.. 
+PF10613 Ligated ion channel L-glutamate- and glycine-binding site<br>Pfam-B_203 (release 22.0). This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine  . It is found in association with Lig_chan, Pfam:PF00060.. 
+PF10614 Tafi-CsgF;<br>Type VIII secretion system (T8SS), CsgF protein. FIGFAMs, Mistry J, Coggill P, Desvaux M. FIG077109 (Release 2.0). The extracellular nucleation-precipitation (ENP) pathway or Type VIII secretion system (T8SS) in Gram-negative (diderm) bacteria is responsible for the secretion and assembly of prepilins for fimbiae biogenesis, the prototypical curli. Besides the T2SS that can be involved in the assembly of prototypical Type 4 pilus, the T4SS that can be involved in the biogenesis of the prototypical pilus T, the T3SS involved in the assembly of the injectisome and the T7SS involved in the formation of the prototypical Type 1 pilus, the T8SS differs in that fibre-growth occurs extracellularly. The curli, also called thin aggregative fimbriae (Tafi), are the only fimbriae dependent on the T8SS. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. In the absence of extracellular polysaccharides Tafi appear curled, although when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix  . CsgF is one of three putative curli assembly factors appearing to act as a nucleator protein. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery  .. 
+PF10615 Protein of unknown function (DUF2470)<br>FIGFAMs, Mistry J, Coggill P. FIG076093 (Release 2.0). This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.. 
+PF10616 Protein of unknown function (DUF2471) <br>FIGFAMs, Mistry J, Coggill P. FIG076041 (Release 2.0). The function of this family is unknown. Members all come from Burkholderia spp. Swiss:A2WH83 is annotated as Serine/threonine-protein kinase, but this could not be confirmed.. 
+PF10617 Protein of unknown function (DUF2474)<br>FIGfam, Mistry J, Coggill P. FIG073099 (Release 2.0). This family of short proteins has no known function.. 
+PF10618 DUF2473; <br>Phage tail tube protein. FIG030252 (Release 2.0). This bacterial family of proteins contains phage tail tube proteins related to the Mu phage protein Swiss:P79679  . Bacteriophage Mu has an eicosahedral head and contractile tail. The tail is composed of an outer sheath and an inner tube.. 
+PF10620 Phosphoribosyl-dephospho-CoA transferase MdcG<br>FIG003211 (Release 2.0). MdcG is a phosphoribosyl-dephospho-CoA transferase that is involved in the biosynthesis of the prosthetic group of malonate decarboxylase  .  Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage. MdcG catalyses the following reaction: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + apo-[acyl-carrier-protein] = holo-[acyl-carrier-protein] + diphosphate.. 
+PF10621 zf-Fe2-S2-FpoO; <br>F420H2 dehydrogenase subunit FpoO . FIGfam, Mistry J, Coggill P. FIG062058 (Release 2.0). This is the FpoO subunit of F420H2 dehydrogenase, an enzyme which oxidises reduced coenzyme F420.  Reduced coenzyme F420 is a universal electron carrier in methanogens.. 
+PF10622 Energy-converting hydrogenase B subunit P (EhbP)<br>FIG124174 (Release 2.0). Ehb (energy-converting hydrogenase B) is an methanogenic archaeal enzyme that functions in one of the metabolic pathways involved in methanol reduction to methane.  This family contains subunit P of Ehb.. 
+PF10623 Plasmid conjugative transfer protein PilI<br>FIG136100 (Release 2.0). The thin pilus of plasmid R64 belongs to the type IV family and is required for liquid matings.  pilI is one of 14 genes that have been identified as being involved in biogenesis of the R64 thin pilus  .. 
+PF10624 Plasmid conjugative transfer entry exclusion protein TraS<br>FIG105028 (Release 2.0). Entry exclusion (Eex) is a process which prevents redundant transfer of DNA between donor cells.  TraS is a protein involved in Eex.  It blocks redundant conjugative DNA synthesis and transport between donor cells, and it is suggested that TraS interferes with a signalling pathway that is required to trigger DNA transfer  .  TraS on the recipient cell is known to form an interaction with TraG on the donor cell  .. 
+PF10625 Universal stress protein B (UspB)<br>FIG002192 (Release 2.0). UspB in Escherichia coli is a 14kDa protein which is predicted to be an integral membrane protein.  Overexpression of UspB results in cell death in stationary phase, and mutants of uspB are sensitive to ethanol exposure during stationary phase  .. 
+PF10626 Conjugative transposon protein TraO<br>FIG055244 (Release 2.0). This is a family of conjugative transposon proteins.. 
+PF10627 Curli assembly protein CsgE<br>FIG091002 (Release 2.0). Curli are a class highly aggregated surface fibres that are part of a complex extracellular matrix.  They promote biofilm formation in addition to other activities.  CsgE is a non-structural protein involved in curli biogenesis  .\.       CsgE forms an outer membrane complex with the curli assembly proteins CsgG and CsgF  .. 
+PF10628 Outer spore coat protein E (CotE)<br>FIG006437 (Release 2.0). CotE is a morphogenic protein that is required for the assembly of the outer coat of the endospore   and spore resistance to lysozyme  . CotE also regulates the expression of cotA, cotB, cotC and other genes encoding spore outer coat proteins  .  The timing of cotE expression has been shown in Bacillus subtilis to affect spore coat morphology but not lysozyme resistance  .. 
+PF10629 Protein of unknown function (DUF2475)<br>This family of proteins has no known function.. 
+PF10630 Protein of unknown function (DUF2476)<br>This is a family of proteins of unknown function.\.     The family is rich in proline residues.. 
+PF10631 Protein of unknown function (DUF2477)<br>This is a family of proteins with no known function. The family is rich in proline residues.. 
+PF10632 He_PIG associated, NEW1 domain of bacterial glycohydrolase<br>Naumoff D, Coggill P. Pfam-B_97991 (release 22.0). The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW1 but its actual function is not known. It is found on proteins which are bacterial galactosidases  . The domain is associated with the He_PIG family, Pfam:PF05345, a putative Ig-containing domain.. 
+PF10633 NPCBM-assoc; <br>NPCBM-associated, NEW3 domain of alpha-galactosidase. Naumoff D, Coggill P. Pfam-B_97993 (release 22.0). The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW3 but its actual function is not known. It is found on proteins which are bacterial galactosidases  . The domain is associated with the NPCBM family, Pfam:PF08305, a novel putative carbohydrate binding module found at the N-terminus of glycosyl hydrolases.. 
+PF10634 Fe2+ transport protein<br>FIG005173 (Release 2.0). This is a bacterial family of periplasmic proteins that are thought to function in high-affinity Fe2+ transport.. 
+PF10635 DisA bacterial checkpoint controller linker region <br>The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by family DisA_N, Pfam:PF02457; the next 146-289 residues is this domain that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), thus forming a spine like-linker between domains 1 and 3. The C-terminal residues of domain 3 are family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis  .. 
+PF10636 Hemin uptake protein hemP<br>FIG024330 (Release 2.0). This is a bacterial family of proteins that are involved in the uptake of the iron source hemin  .. 
+PF10637 Oxoglutarate and iron-dependent oxygenase degradation C-term<br>Pfam-B_18095 (release 22.0). Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N in the presence of oxygen.  The domain is conserved from yeasts to humans. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts  .. 
+PF10638 Spindle body associated protein C-terminus  <br>This C-terminal domain of spindle-body-associated protein Sfi1 has an important role to play in the bridge-splitting during bi-polar spindle assembly, and this separation event possibly requires interaction with integral components of the nuclear envelope, such as the Mps2-Bbp1 complex  . Centrally to this domain is a region carrying centrin-binding repeats with repeating units containing tryptophan, family Sfi1_central, Pfam:PF08457.. 
+PF10639 Uncharacterised protein family UPF0546<br>This family of proteins has no known function.  Many members are annotated as potential transmembrane proteins.. 
+PF10640 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase<br>This domain is the N-terminus of the large subunit viral mRNA capping enzyme, and carries both the ATPase and the guanylyltransferase activities of the enzyme. The guanylyltransferase enzymatic region runs from residues 242 (leucine)-273(arginine)  , the core of the acitve site being the lysine residue at 260  . The ATPase activity is at the very N-terminal part of the domain  .. 
+PF10642 Mitochondrial import receptor subunit or translocase<br>Pfam-B_89651 (release 22.0). This protein family is very short and is only found in yeasts. Tom5 is one of three very small translocases of the mitochondrial outer membrane. Tom5 links mitochondrial preprotein receptors to the general import pore  . Although Tom5 has allegedly been identified in vertebrates this could not be confirmed.. 
+PF10643 Photosystem P840 reaction-centre cytochrome c-551<br>FIGFam, Mistry J, Coggill P. FIG055090 (Release 2.0). A photosynthetic reaction-centre complex is found in certain green sulphur bacteria such as Chlorobium vibrioforme which are anaerobic photo-auto-trophic organisms. The primary electron donor is P840, a probable B-Chl a dimer, and the primary electron acceptor is a B-Chl monomer. Also on the donor side c-type cytochromes are known to function as electron donors to photo-oxidised P840. This family is thus the secondary endogenous donor of the photosynthetic reaction-centre complex and is a membrane-bound cytochrome containing a single haem group.. 
+PF10644 Misat_Myo_SegII;<br>Misato Segment II tubulin-like domain. Pfam-B_7826 (release 21.0). The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins Pfam:PF00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils  . This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).. 
+PF10645 Carbohydrate binding<br>Pfam-B_63360 (release 22.0). This is a carbohydrate binding domain which has been shown in Schizosaccharomyces pombe to be required for septum localisation  .. 
+PF10646 GerMN;<br>Sporulation and spore germination. The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. The domain is found in a number of different bacterial species both alone and in association with other domains such as Amidase_3 Pfam:PF01520, Gmad1 and Gmad2.  It is predicted to have a novel alpha-beta fold.. 
+PF10647 Lipoprotein LpqB beta-propeller domain<br>The Gmad1 domain is found associated with the GerMN family, Pfam:PF10646, in bacterial spore formation. It is predicted to have a beta-propeller fold and to have a passive binding role rather than a catalytic function owing to the low number of conserved hydrophilic residues.. 
+PF10648 Immunoglobulin-like domain of bacterial spore germination<br>This domain is found linked to the GerMN domain Pfam:PF10646 in some bacterial proteins. It is predicted to contain an immunoglobulin-like all-beta fold.. 
+PF10649 Protein of unknown function (DUF2478)<br>FIGfam, Mistry J, Coggill P. FIG046046 (Release 2.0) . This is a family of hypothetical bacterial proteins found in the vicinity of Molybdenum ABC transporter ATP-binding gene-products MobA MobB and MobC. However the function could not be confirmed. This family appears to belong to the P-loop superfamily by alignment to Pfam:PF03266. However, the characteristic P-loop sequence motif appears to have diverged beyond recognition in this family.. 
+PF10650 Putative zinc-finger domain<br>This domain is conserved in fungi and might be a zinc-finger domain as it contains three conserved Cs and an H in the C-x8-C-x5-C-x3-H conformation typical of a zinc-finger.. 
+PF10651 Domain of unknown function (DUF2479)<br>FIGfam, Mistry J, Coggill P. FIG015005 (Release 2.0). This domain is found in phage from a number of different bacteria.  It is purported to be a putative long tail fibre (Bacteriophage A118) protein, but this could not be confirmed.. 
+PF10652 Protein of unknown function (DUF2480)<br>FIGfam, Mistry J, Coggill P. FIG020045 (Release 2.0) . All the members of this family are uncharacterised proteins, but the environment in which they are found on the bacterial genome suggests a function as a glucose-6-phosphate isomerase (EC 5.3.1.9).  This could not, however, be confirmed.. 
+PF10653 Protein gp45 of Bacteriophage A118<br>FIGfam, Mistry J, Coggill P. FIG0160151 (Release 2.0). This domain is found in bacteriophage and is thought to have a gp45 function within the phage tail-fibre system.. 
+PF10654 DUF2482; <br>Protein of unknown function (DUF2481) . FIGfam, Mistry J, Coggill P. FIG020094 (Release 2.0). This is a hypothetical protein family homologous to Lmo2305 in Bacteriophage A118 systems.. 
+PF10655 Hypothetical protein of unknown function (DUF2482)<br>FIGfam, Mistry J, Coggill P. FIG030041 (Release 2.0). All the members of this very small, very short family are derived from bacteriophages, of the SA bacteriophages 11, Mu50B, system, and from the Staphylococcal_phi-Mu50B-like_prophages subsystem. All members are hypothetical proteins.. 
+PF10656 Hypothetical protein of unknown function (DUF2483)<br>FIGfam, Mistry J, Coggill P. FIG032091 (Release 2.0). This is a family of proteins found in bacteriophage particularly of the SA bacteriophages 11, Mu50B, family, homologous to phi-ETA orf16.. 
+PF10657 Photosystem P840 reaction centre protein PscD<br>FIGfam, Mistry J, Coggill P. FIG031038 (Release 2.0). The photosynthetic reaction centres (RCs) of aerotolerant organisms contain a heterodimeric core, built up of two strongly homologous polypeptides each of which contributes five transmembrane peptide helices to hold a pseudo-symmetric double set of redox components. Two molecules of PscD are housed within a subunit. PscD may be involved in stabilising the PscB component since it is found to co-precipitate with FMO (Fenna-Mathews-Olson BChl a-protein) and PscB. It may also be involved in the interaction with ferredoxin  .. 
+PF10658 Protein of unknown function (DUF2484)<br>FIGfam, Mistry J, Coggill P. FIG030013 (Release 2.0). A role of this family in UDP-N-acetylenolpyruvoylglucosamine reductase, as MurB, could not be confirmed.. 
+PF10659 Trypanosome variant surface glycoprotein C-terminal domain<br>Pfam-B_1351 (release 3.0). The trypanosome parasite expresses these proteins to evade the immune response.. 
+PF10660 Iron-containing outer mitochondrial membrane protein N-terminus  <br>MitoNEET_N is the N-terminal region of the MitoNEET and Miner-type proteins that carry a zf-CDGSH, Pfam:PF09360, redox-active 2Fe-2S cluster.  The whole protein regulates oxidative capacity. The domain is an anchor sequence that tethers the protein to the outer membrane.. 
+PF10661 WXG100 protein secretion system (Wss), protein EssA<br>FIGfam, Mistry J, Coggill P, Desvaux M. FIG043089 (Release 2.0). The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (Pfam:PF06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (Pfam:PF10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (Pfam:PF01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria  .. 
+PF10662 Ethanolamine utilisation - propanediol utilisation<br>FIGfam, Mistry J, Coggill P. FIG047026 (Release 2.0). Members of this family function in ethanolamine and propanediol degradation pathways, however the exact roles of these proteins is poorly understood [1-3].. 
+PF10664 DUF2485; NADHqo1-M; NADHdh-M;<br>Cyanobacterial and plastid NDH-1 subunit M. FIGfam, Mistry J, Coggill P. FIG006356 (Release 2.0). The proton-pumping NADH:ubiquinone oxidoreductase catalyses the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides.  Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 sub-complexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit  . The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms  . The three subunits of NDH-1, NdhM, NdhN and NdhO are essential for effecting cyclic electron flow around photosystem I, by supplying extra-ATP for photosynthesis in both plastids and cyanobacteria [3, 4].. 
+PF10665 Phage_Gp9;<br>Minor capsid protein. FIGfam, Mistry J, Coggill P. FIG016324 (Release 2.0). This is a putative tail-knob or minor capsid protein from bacteriophages.. 
+PF10666 Phage protein Gp14<br>FIGfam, Mistry J, Coggill P. This phage protein family is of unknown function but is expressed from within a cluster of tail- and base plate-producing genes  .. 
+PF10667 Protein of unknown function (DUF2486)<br>FIGfam, Mistry J, Coggill P. FIG008383 (Release 2.0). This family is made up of members from various Burkholderia spp. The function is unknown.. 
+PF10668 Phage terminase small subunit<br>FIGfams, Mistry J, Coggill P. FIG022212 (Release 2.0). This family of small highly conserved proteins come from a subset of Firmicute species. Its putative function is as a phage terminase small subunit.. 
+PF10669 Protein gp23 (Bacteriophage A118)<br>FIGfam, Mistry J, Coggill P. FIG018382 (Release 2.0). This is the highly conserved family of the major tail subunit protein.. 
+PF10670 NikM;<br>Domain of unknown function (DUF4198). Pfam-B_42996 (release 22.0). This family was previously missannotated in Pfam as NikM.. 
+PF10671 Toxin co-regulated pilus biosynthesis protein Q<br>FIGfam, Mistry J, Coggill P. FIG032035 (Release 2.0). The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonisation in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localisation of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.. 
+PF10672 S-adenosylmethionine-dependent methyltransferase<br>Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyse the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalysed by the S-adenosylmethionine-dependent methyltransferases.. 
+PF10673 Protein of unknown function (DUF2487)<br>This is a bacterial family of uncharacterised proteins.. 
+PF10674 DUF2488;<br>Protein of unknown function (DUF2488). This protein is conserved in the green lineage and located in the chloroplast.. 
+PF10675 Protein of unknown function (DUF2489)<br>This is a bacterial family of uncharacterised proteins.. 
+PF10676 Spore germination protein gerPA/gerPF<br>This is a bacterial family of proteins that are required for the formation of functionally normal spores.  Proteins in this family may be involved in establishing normal coat structure and/or permeability which could control the access of germinants to their receptor.. 
+PF10677 Protein of unknown function (DUF2490)<br>This is a bacterial family of uncharacterised proteins. They appear to belong to the outer membrane beta barrel superfamily.. 
+PF10678 Protein of unknown function (DUF2492)<br>This is a bacterial family of uncharacterised proteins.. 
+PF10679 Protein of unknown function (DUF2491)<br>This is a bacterial family of uncharacterised proteins.. 
+PF10680 RNA polymerase I specific transcription initiation factor<br>Pfam-B_44021 (release 22.0). Initiation of transcription of ribosomal DNA (rDNA) in yeast involves an interaction of upstream activation factor (UAF) with the upstream element of the promoter, to form a stable UAF-template complex. UAF, together with the TATA-binding transcription initiation factor protein TBP, then recruits an essential core factor to the promoter, to form a stable preinitiation complex  . This Rrn9 domain, which seems to be constrained to fungi, is the two highly conserved regions of proteins which form one of the subunits of UAF and appears to be the region responsible for the interaction with TBP. The family includes the S.pombe Arc1 protein, Swiss:Q10204, which is found to be essential for the accumulation of condensin at kinetochores  .. 
+PF10681 Chaperone for protein-folding within the ER, fungal<br>Pfam-B_27706 (release 22.0). This conserved fungal family is an essential molecular chaperone in the endoplasmic reticulum. Molecular chaperones transiently interact with unfolded proteins to inhibit their self-aggregation and to support their folding and/or assembly. Rot1 is a general chaperone with some substrate specificity, its substrates being the structurally unrelated Kre5 Kre6 Big1 Atg22, which are type I, type II, and polytopic membrane proteins. The dependencies of each for Rot1 do not share similarities. However, their folding does require BiP, and one of these proteins was simultaneously associated with both Rot1 and BiP. In addition, Rot1 may cooperate with BiP/Kar2 in the folding of Kre6  .. 
+PF10682 Glycoprotein of human cytomegalovirus HHV-5<br>This is glycoprotein UL40 from human cytomegalovirus or herpesvirus 5. The signal sequence of the UL40 polypeptide contains an HLA-E ligand identical with HLA-Cw*0304. The first 37 residues of UL40, including this ligand, are predicted to encode a signal peptide.  The virus thus prevents the lysis by NK (natural killer) cells of the cell it has invaded [1-2].. 
+PF10683 Hermes_DBD;<br>Hermes transposase DNA-binding domain  . This domain confers specific DNA-binding on Hermes transposase  .. 
+PF10684 Putative biofilm-dependent modulation protein<br>This is a family of tightly conserved proteins from Enterobacteriaceae which are annotated as being biofilm-dependent modulation protein homologues.. 
+PF10685 Stress-induced bacterial acidophilic repeat motif<br>This repeat is found in proteins which are expressed under conditions of stress in bacteria. The repeat contains a highly conserved, characteristic sequence motif,KGG, that is also recognised by plants and lower eukaryotes and repeated in their LEA (late embryogenesis abundant) family of proteins, thereby rendering those proteins bacteriostatic. An example of such an LEA family is LEA_5, Pfam:PF00477. Further downstream from this motif is a Walker A, nucleotide binding, motif GXXXXGK(S,T), that in YciG of E coli, eg Swiss:Q8X7B4, is QSGGNKSGKS [URL]. YciG is expressed as part of a three-gene operon, yciGFE, and this operon is induced by stress and is regulated by RpoS, which controls the general stress-response in E coli. YciG was shown to be important for stationary-phase resistance to thermal stress and in particular to acid stress.. 
+PF10686 Protein of unknown function (DUF2493)<br>Members of this family are all Proteobacteria. The function is not known.. 
+PF10688 Bacterial inner membrane protein<br>This is a family of inner membrane proteins. Many of the members are YgjV protein.. 
+PF10689 Protein of unknown function (DUF2496)<br>This family consists of proteins from Gammaproteobacteria spp. Many members are annotated as being like the E coli protein YbaM.. 
+PF10690 Myticin pre-proprotein from the mussel<br>Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis, the Mediterranean mussel. Some isoforms show antibacterial activity against gram-positive bacteria, while others are additionally active against the fungus Fusarium oxysporum and a gram-negative bacterium, Escherichia coli D31.  Myticin-prepro is the precursor peptide. The mature molecule, named myticin, consists of 40 residues, with four intramolecular disulfide bridges and a cysteine array in the primary structure different from that of previously characterised cysteine-rich antimicrobial peptides. The first 20 amino acids are a putative signal peptide, and the antimicrobial peptide sequence is a 36-residue C-terminal extension. Such a structure suggests that myticins are synthesised as prepro-proteins that are then processed by various proteolytic events before storage in the haemocytes as the active peptide. Myticin precursors are expressed mainly in the haemocytes. The family Mytilin has been merged into this family.. 
+PF10691 Protein of unknown function (DUF2497) <br>Members of this family belong to the Alphaproteobacteria. The function of the family is not known.. 
+PF10692 Protein of unknown function (DUF2498)<br>Members of this family are Gammaproteobacteria. Many are annotated as like E coli protein YciN. The function is not known.. 
+PF10693 Protein of unknown function (DUF2499)<br>Members of this family are found in plants, lower eukaryotes, and bacteria and the chloroplast where it is annotated as Ycf49 or Ycf49-like.  The function is not known though several members are annotated as putative membrane proteins.. 
+PF10694 Protein of unknown function (DUF2500)<br>The members of this family are largely confined to the Gammaproteobacteria. The function is not known.. 
+PF10696 Protein of unknown function (DUF2501)<br>Members of this family are all Proteobacteria. Several are annotated as being YjjA or YjjA-like, but this protein is uncharacterised.. 
+PF10697 Protein of unknown function (DUF2502)<br>Members of this family are all Gammaproteobacteria. The function is not known.. 
+PF10698 Protein of unknown function (DUF2505)<br>Members of this family are all Actinobacteria. The function is not known.. 
+PF10699 Male gamete fusion factor<br>The gene encoding Arabidopsis HAP2 is allelic with GCS1 (Generative cell-specific protein 1). HAP2 is expressed only in the haploid sperm and is required for efficient guidance of the pollen tube to the ovules. In Arabidopsis the protein is a predicted membrane protein with an N-terminal secretion signal, a single transmembrane domain and a C-terminal histidine-rich domain  . HAP2-GCS1 is found from plants to lower eukaryotes and is necessary for the fusion of the gametes in fertilisation. It is involved in a novel mechanism for gamete fusion where a first species-specific protein binds male and female gamete membranes together after which a second, broadly conserved protein, either directly or indirectly, causes fusion of the two membranes together. The broadly conserved protein is represented by this HAP2-GCS1 domain, conserved from plants to lower eukaryotes  . In Plasmodium berghei the protein is expressed only in male gametocytes and gametes, having a male-specific function during the interaction with female gametes, and being indispensable for parasite fertilisation. The gene in plants and eukaryotes might well have originated from acquisition of plastids from red algae  .. 
+PF10702 Protein of unknown function (DUF2507)<br>This family is conserved in Firmicutes. The function is not known.. 
+PF10703 Molybdenum cofactor biosynthesis protein F<br>MoaF protein is essential for the production of the monoamine-inducible 30kDa protein in Klebsiella  . It is necessary for reconstituting organoautotrophic growth in Ralstonia eutropha  . It is conserved in Proteobacteria and some lower eukaryotes. The operon regulating the Moa genes is responsible for molybdenum cofactor biosynthesis.. 
+PF10704 Protein of unknown function (DUF2508)<br>This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.. 
+PF10705 Chloroplast protein precursor Ycf15 putative<br>In some species of plants the ycf15 gene is probably not a protein-coding gene because the protein in these species has premature stop codons. Most of the members of the family are hypothetical or uncharacterised  .. 
+PF10706 Aminoglycoside-2''-adenylyltransferase<br>This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin  . The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents  .. 
+PF10707 PhoP regulatory network protein YrbL<br>This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner  .. 
+PF10708 Protein of unknown function (DUF2510)<br>This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.. 
+PF10709 Protein of unknown function (DUF2511)<br>This family is conserved in bacteria. The function is not known.. 
+PF10710 Protein of unknown function (DUF2512)<br>Proteins in this family are predicted to be integral membrane proteins, and many of them are annotated as being YndM protein. They are all found in Firmicutes. The true function is not known.. 
+PF10711 Hypothetical protein (DUF2513)<br>This family is found in bacteria. The function is not known.. 
+PF10712 NAD-specific glutamate dehydrogenase<br>The members of this are annotated as being NAD-specific glutamate dehydrogenase encoded in antisense gene pair with DnaK-J  .. 
+PF10713 Protein of unknown function (DUF2509) <br>This family is conserved in Proteobacteria. The function is not known but many of the members are annotated as protein YgdB.. 
+PF10714 Late embryogenesis abundant protein 18<br>This is a family of late embryogenesis-abundant proteins There is high accumulation of this protein in dry seeds, and in the roots of full-grown plants in response to dehydration and ABA (abscisic acid application) treatments  . This LEA protein disappears after germination. It accumulates in growing regions of well irrigated hypocotyls and meristems suggesting a role in seedling growth resumption on rehydration  . As a group the LEA proteins are highly hydrophilic, contain a high percentage of glycine residues, lack Cys and Trp residues and do not coagulate upon exposure to high temperature, and for these reasons are considered to be members of a group of proteins called hydrophilins  . Expression of the protein is negatively regulated during etiolating growth, particularly in roots, in contrast to its expression patterns during normal growth  .. 
+PF10715 Endoribonuclease RegB T4-bacteriophage encoded<br>The RegB endoribonuclease encoded by bacteriophage T4 is a unique sequence-specific nuclease that cleaves in the middle of GGAG or, in a few cases, GGAU tetranucleotides, preferentially those found in the Shine-Dalgarno regions of early phage mRNAs. Phage RB49 in addition to gpRegB utilises Escherichia coli endoribonuclease E for the degradation of its transcripts for gene regB. The deduced primary structure of RegB proteins of 32 phages studied is almost identical to that of T4, while the sequences of RegB encoded by phages RB69, TuIa and RB49 show substantial divergence from their T4 counterpart.. 
+PF10716 NADH dehydrogenase transmembrane subunit<br>The NdhL family is a component of the NDH-1L complex that is one of the proton-pumping NADH:ubiquinone oxidoreductases that catalyse the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. NDH-1L is essential for photoheterotrophic cell growth. NdhL appears to contain two transmembrane helices and it is necessary for the functioning of though not the correct assembly of the NDH-1 complex in Synechocystis 6803. The conservation between cyanobacteria and green plants suggests that chloroplast NDH-1 complexes contain related subunits  .. 
+PF10717 Occlusion-derived virus envelope protein ODV-E18<br>This family of occlusion-derived viral envelope proteins are detected in viral-induced intranuclear microvesicles and are not detected in the plasma membrane, cytoplasmic membranes, or the nuclear envelope. The ODV-E18 protein is encoded by baculovirus late genes with transcription initiating from a TAAG motif. It exists as a dimer in the ODV envelope and contains a hydrophobic domain which is putatively acting as a target or retention signal for intranuclear microvesicles  .. 
+PF10718 Hypothetical chloroplast protein Ycf34<br>This family is of proteins annotated as hypothetical chloroplast protein YCF34.  The function is not known.. 
+PF10719 Late competence development protein ComFB<br>This family is conserved in bacteria. Some members, with three conserved cysteines, are annotated as late competence development protein ComFB.. 
+PF10720 Protein of unknown function (DUF2515)<br>This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.. 
+PF10721 Protein of unknown function (DUF2514)<br>This family is conserved in bacteria and some viruses. The function is not known.. 
+PF10722 Putative bacterial sensory transduction regulator<br>YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabiliser for some other unstable proteins  . This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.. 
+PF10723 Replication regulatory protein RepB<br>This is a family of proteins which regulate replication of rolling circle replication (RCR) plasmids that have a double-strand replication origin (dso). Regulation of replication of RCR plasmids occurs mainly at initiation of leading strand synthesis at the dso, such that Rep protein concentration controls plasmid replication  .. 
+PF10724 Protein of unknown function (DUF2516)<br>This family is conserved in Actinobacteria. The function is not known.. 
+PF10725 Protein of unknown function (DUF2517)<br>This family is conserved in Proteobacteria. Several members are annotated as being protein YbfA. The function is not known.. 
+PF10726 Protein of function (DUF2518)<br>This family is conserved in Cyanobacteria. Several members are annotated as the protein Ycf51.  The function is not known.. 
+PF10727 Rossmann-like domain<br>This family of proteins contain a Rossmann-like domain.. 
+PF10728 Domain of unknown function (DUF2520)<br>This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.. 
+PF10729 Cell division activator CedA<br>CedA is made up of four antiparallel beta-strands and an alpha-helix. It activates cell division by inhibiting chromosome over-replication. This is mediated by binding to dsDNA via the beta-sheet. [1,2].. 
+PF10730 Protein of unknown function (DUF2521)<br>Family of unknown function specific to Bacillus.. 
+PF10731 Thrombin inhibitor from mosquito<br>Members of this family are all inhibitors of thrombin, the peptidase that is at the end of the blood coagulation cascade and which creates the clot by cleaving fibrinogen.  The interaction between thrombin and fibrinogen involves two different areas of contact - via the thrombin active site and via a second substrate-binding site known as an exosite.  The inhibitor acts by blocking the exosite, rather than by interacting with the active site.  The inhibitors are from mosquitoes that feed on human blood and which, by inhibiting thrombin, prevent the blood from clotting and keep it flowing.. 
+PF10732 Protein of unknown function (DUF2524)<br>This family of proteins with unknown function appears to be restricted to Bacillaceae bacteria. . 
+PF10733 Protein of unknown function (DUF2525)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.. 
+PF10734 Protein of unknown function (DUF2523)<br>This is a family of phage related proteins whose function is uncharacterised.. 
+PF10735 Protein of unknown function (DUF2526)   <br>This family of proteins with unknown function is restricted to Enterobacteriaceae. The family has a highly conserved sequence.. 
+PF10736 Protein of unknown function (DUF2627) <br>This family of proteins with unknown function appears to be restricted to a family of Enterobacterial proteins. It has a highly conserved sequence.. 
+PF10737 Spore germination protein GerPC<br>GerPC is required for the formation of functionally normal spores. The gerP locus encodes a number of proteins which are thought to be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor  .. 
+PF10738 Probable lipoprotein LpqN<br>This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein  .. 
+PF10739 Protein of unknown function (DUF2550)<br>This family is conserved in Corynebacterineae. The function is not known though most members are annotated as either secreted, or membrane, proteins.. 
+PF10740 Protein of unknown function (DUF2529)<br>This family is conserved in the Bacillales. The function is not known. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.. 
+PF10741 GspM_II;<br>Type II secretion system (T2SS), protein M subtype b. Mistry J, Coggill P, Desvaux M. The T2SMb family is conserved in Proteobacteria and Actinobacteria, and differs from the T2SM proteins in Vibrio spp. (Pfam:PF04612).. 
+PF10742 Protein of unknown function (DUF2555)<br>This family is conserved in Cyanobacteria. The function is not known.. 
+PF10743 Regulatory phage protein cox<br>This family of phage Cox proteins is expressed by Enterobacteria phages. The Cox protein is a 79-residue basic protein with a predicted strong helix-turn-helix DNA-binding motif. It inhibits integrative recombination and it activates site-specific excision of the HP1 genome from the Haemophilus influenzae chromosome, Hp1. Cox appears to function as a tetramer. Cox binding sites consist of two direct repeats of the consensus motif 5'-GGTMAWWWWA, one Cox tetramer binding to each motif. Cox binding interferes with the interaction of HP1 integrase with one of its binding sites, IBS5. This competition is central to directional control. Both Cox binding sites are needed for full inhibition of integration and for activating excision, because it plays a positive role in assembling the nucleoprotein complexes that produce excisive recombination, by inducing the formation of a critical conformation in those complexes  .. 
+PF10744 Med1-Trap220; <br>Mediator of RNA polymerase II transcription subunit 1. Pfam-B_51442 (release 22.0). Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II.  This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions  . Med1 is part of the tail region of the Mediator complex  .. 
+PF10745 Protein of unknown function (DUF2530)<br>This family of proteins with unknown function appears to be restricted to mycobacteria.. 
+PF10746 Phage holin family 6<br>Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis.. 
+PF10747 Protein of unknown function (DUF2522)<br>This family of proteins with unknown function appears to be restricted to Bacillus.. 
+PF10748 Protein of unknown function (DUF2531)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10749 Protein of unknown function (DUF2534)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10750 Protein of unknown function (DUF2536)<br>This family of proteins with unknown function appears to be restricted to Bacillus spp. Structural modelling suggests this domain may bind nucleic acids  .. 
+PF10751 Protein of unknown function (DUF2535)<br>This family of proteins with unknown function appears to be restricted to Bacillus spp.. 
+PF10752 Protein of unknown function (DUF2533) <br>This family of proteins with unknown function appears to be restricted to Bacillus spp.. 
+PF10753 Protein of unknown function (DUF2566)<br>This family is conserved in Enterobacteriaceae. The function is not known.. 
+PF10754 Protein of unknown function (DUF2569)<br>This family is conserved in bacteria. The function is not known, but several members are annotated as being YdgK or a homologue thereof.. 
+PF10756 DUF2581;<br>This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales.  Although several members are annotated as RbiX homologues, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.. 
+PF10755 Protein of unknown function (DUF2585)<br>This family is conserved in Proteobacteria. The function is not known.. 
+PF10757 Biofilm formation regulator YbaJ<br>YbaJ regulates biofilm formation. It also has an important role in the regulation of motility in the biofilm. YbaJ functions in increasing conjugation, aggregation and decreasing the motility, resulting in an increase of biofilm  . 
+PF10758 Protein of unknown function (DUF2586)<br>This bacterial family of proteins has no known function.. 
+PF10759 Protein of unknown function (DUF2587)<br>This is a bacterial family of proteins with no known function.. 
+PF10761 Protein of unknown function (DUF2590)<br>This family of proteins has no known function.. 
+PF10762 Protein of unknown function (DUF2583)   <br>Some members in this family of proteins are annotated as YchH however currently no function is known.. 
+PF10763 Protein of unknown function (DUF2584)<br>This bacterial family of proteins have no known function.. 
+PF10764 Inhibitor of sigma-G Gin<br>Gin allows sigma-F to delay late forespore transcription by preventing sigma-G to take over before the cell has reached a critical stage of development. Gin is also known as CsfB  .. 
+PF10765 Protein of unknown function (DUF2591)<br>This bacterial family of proteins has no known function.. 
+PF10766 Protein of unknown function (DUF2592)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10767 Protein of unknown function (DUF2593)<br>This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YbjO however currently there is no known function.. 
+PF10768 Class II flagellar assembly regulator<br>The FliX protein is possibly a transient component of the flagellum that is required for the assembly process. FliX may contribute to the targeting or assembly of the P- and L-ring protein monomers at the cell pole. The family carries a potential N-terminal signal sequence and at least one transmembrane domain indicating that it might function either in or in association with the cell membrane  .. 
+PF10769 Protein of unknown function (DUF2594)<br>This family of proteins with unknown function appear to be restricted to Enterobacteriaceae.. 
+PF10771 Protein of unknown function (DUF2582)<br>This family is conserved in bacteria and archaea. The function is not known.. 
+PF10772 Protein of unknown function (DUF2597)<br>This family of proteins has no known function.. 
+PF10774 BssS;<br>Domain of unknown function (DUF4226). This family of mycobacterial proteins are uncharacterised.. 
+PF10775 ATP synthase complex subunit h<br>Subunit h is a component of the yeast mitochondrial F1-F0 ATP synthase. It is essential for the correct assembly and functioning of this enzyme. Subunit h occupies a central place in the peripheral stalk between the F1 sector and the membrane  .. 
+PF10776 Protein of unknown function (DUF2600)<br>This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.. 
+PF10777 Inner membrane protein YlaC<br>Members of this family include proteins annotated as inner membrane protein YlaC in E. coli and Salmonella. The function of this family is unknown.. 
+PF10778 Halocarboxylic acid dehydrogenase DehI<br>Haloacid dehalogenases catalyse the removal of halides from organic haloacids. DehI can process both L- and D-substrates.  A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuration of either L- or D-substrates in contrast to D-only enzymes  .. 
+PF10779 Haemolysin XhlA<br>XhlA is a cell-surface associated haemolysin that lyses the two most prevalent types of insect immune cells (granulocytes and plasmatocytes) as well as rabbit and horse erythrocytes  . This family has had DUF1267, Pfam:PF06895, merged into it.. 
+PF10780 39S ribosomal protein L53/MRP-L53<br>MRP-L53 is also known as Mrp144. It is part of the 39S ribosome  .. 
+PF10781 Dextransucrase DSRB<br>DSRB is a novel dextransucrase which produces a dextran different from the typical dextran, as it contains (1-6) and (1-2) linkages, when this strain is grown in the presence of sucrose  .. 
+PF10782 Protein of unknown function (DUF2602)<br>This bacterial family of proteins has no known function.. 
+PF10783 Protein of unknown function (DUF2599)<br>This family is conserved in Actinobacteria. The function is not known.. 
+PF10784 Plasmid stability protein<br>This family is conserved in the Enterobacteriales. It is a putative plasmid stability protein in that it is expressed from the operon involved in stability, but its actual function has not yet been characterised.. 
+PF10785 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit<br>This family is the N-terminal domain of NADH-ubiquinone oxidoreductase 21 kDa subunits from fungi, lower metazoa and plants.. 
+PF10786 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)<br>This family is conserved in Firmicutes and Proteobacteria. Several members are annotated as being glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49) but this could not be confirmed.. 
+PF10787 Uncharacterised protein from bacillus cereus group<br>This family is conserved in the Bacillus cereus group. Several members are called YfmQ but the function is not known.. 
+PF10788 Protein of unknown function (DUF2603)<br>This family is conserved in Epsilon-proteobacteria. The function is not known.. 
+PF10789 Phage RNA polymerase binding, RpbA<br>Upon infection the RpbA encode phage protein binds to the ADP-ribosylated core RNA polymerase and modulates function to preferentially bind T4 promoters.\.      This is a non-essential protein to the phage life cycle.. 
+PF10790 Protein of Unknown function (DUF2604)<br>Family of bacterial proteins with undetermined function.. 
+PF10791 Mitochondrial F1-F0 ATP synthase subunit F of fungi<br>The membrane bound F1-FO-type H+ ATP synthase of mitochondria catalyses the terminal step in oxidative respiration converting the generation of the electrochemical gradient into ATP for cellular biosynthesis. The general structure and the core subunits of the enzyme are highly conserved in both prokaryotic and eukaryotic organisms.. 
+PF10792 Protein of unknown function (DUF2605)<br>This family is conserved in Cyanobacteria. The function is not known.. 
+PF10793 Gloverin-like protein <br>This family of proteins are Gloverin-like. Gloverin is a 13.8kDa inducible antibacterial insect protein which inhibits the synthesis of vital outer membrane proteins leading to a permeable outer membrane. Gloverin contains a large number of glycine residues  .. 
+PF10794 Protein of unknown function (DUF2606)<br>Family of bacterial proteins with unknown function. These proteins have been classified as membrane proteins. 
+PF10795 Protein of unknown function (DUF2607)<br>This family is conserved in Gammaproteobacteria. The function is not known.. 
+PF10796 Sigma-S stabilisation anti-adaptor protein <br>This family is conserved in Enterobacteriaceae. It is one of a series of proteins, expressed by these bacteria in response to stress, that help to regulate Sigma-S, the stationary phase sigma factor of Escherichia coli and Salmonella. IraP is essential for Sigma-S stabilisation in some but not all starvation conditions  .. 
+PF10797 Protein of unknown function<br>This family is conserved in Firmicutes and Proteobacteria. The function is not known but several members are annotated as being homologues of E coli YhfT, a protein thought to be involved in fatty acid oxidation.. 
+PF10798 Biofilm development protein YmgB/AriR<br>YmgB is part of the three gene cluster ymgABC which has a role in biofilm development and stability. YmgB represses biofilm formation in rich medium containing glucose, decreases cellular motility and also protects the cell from acid which indicates that YmgB has an important function in acid-resistance  . YmgB binds as a dimer to genes which are important for biofilm formation via a ligand. Due to its important function in acid resistance it is also known as AriR (regulator of acid resistance influenced by indole)  .. 
+PF10799 Biofilm formation protein (YliH/bssR)<br>YliH is induced in biofilms and is involved in repression of motility in the biofilms  . YliH is also known as bssR (regulator of biofilm through signal secreton).. 
+PF10800 Protein of unknown function (DUF2528) <br>This family of proteins has no known function. Some of the sequences are annotated as ea10 however the function of this protein is unknown.. 
+PF10801 Protein of unknown function (DUF2537)<br>This bacterial family of proteins has no known function.. 
+PF10802 Protein of unknown function (DUF2540)<br>This family of proteins with unknown function appears to be restricted to Methanococcus.. 
+PF10803 DUF2539;<br>Spore germination GerPB. Members of this family are required for formation of functionally normal spores. They may be involved in the establishment of spore coat structure or permeability  .. 
+PF10804 Protein of unknown function (DUF2538) <br>This family of proteins has no known function.. 
+PF10805 Protein of unknown function (DUF2730)<br>This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF10806 Protein of unknown function (DUF2731)<br>This eukaryotic family of proteins has no known function.. 
+PF10807 Protein of unknown function (DUF2541)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. All proteins are annotated as YaaI precursor however currently no function is known.. 
+PF10808 Protein of unknown function (DUF2542) <br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.. 
+PF10809 Protein of unknown function (DUF2732)<br>This family of proteins has no known function.. 
+PF10810 Protein of unknown function (DUF2545)   <br>This family of proteins with unknown function is restricted to Enterobacteriaceae. The sequence is highly conserved.. 
+PF10811 Protein of unknown function (DUF2532)<br>This bacterial family of proteins has no known function.. 
+PF10812 Protein of unknown function (DUF2561)<br>This family of proteins with unknown function appears to be restricted to Mycobacterium spp.. 
+PF10813 Protein of unknown function (DUF2733)<br>This viral family of proteins has no known function.. 
+PF10814 Protein of unknown function (DUF2562)<br>This protein of unknown function appears to be restricted to Mycobacterium spp.. 
+PF10815 ComZ<br>ComZ is part of a two gene operon. It affects competence regulation by negatively affecting the transcription of the ComG operon. ComZ contains a leucine zipper motif  .. 
+PF10816 Domain of unknown function (DUF2760)<br>Gunasekaran P, Mistry J. Pfam-B_001564 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF10817 Protein of unknown function (DUF2563)<br>This family of proteins with unknown function appears to be restricted to Mycobacterium.. 
+PF10818 Protein of unknown function (DUF2547)<br>This bacterial family of proteins has no known function.. 
+PF10819 Protein of unknown function (DUF2564)     <br>This family of proteins with unknown function appears to be restricted to Bacillus spp.. 
+PF10820 Protein of unknown function (DUF2543)<br>This family of proteins with unknown function appear to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.. 
+PF10821 Protein of unknown function (DUF2567)<br>This is a bacterial family of proteins with unknown function.. 
+PF10823 Protein of unknown function (DUF2568)<br>One member in this family is annotated as yrdB which is part of a four gene operon however currently no function is known.. 
+PF10824 Protein of unknown function (DUF2580)<br>This family of proteins with unknown function appears to be mainly found in actinobacteria.. 
+PF10825 Protein of unknown function (DUF2752)<br>Gunasekaran P, Mistry J. Pfam-B_001601 (release 23.0). This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.. 
+PF10826 Protein of unknown function (DUF2551) <br>This Archaeal family of proteins has no known function.. 
+PF10827 Protein of unknown function (DUF2552) <br>This bacterial family of proteins has no known function.. 
+PF10828 Protein of unknown function (DUF2570)<br>This is a family of proteins with unknown function.. 
+PF10829 Protein of unknown function (DUF2554)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10830 Protein of unknown function (DUF2553)<br>This family of bacterial proteins has no known function.. 
+PF10831 Protein of unknown function (DUF2556)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10832 Protein of unknown function (DUF2559)<br>This family of proteins appear to be restricted to Enterobacteriaceae. The sequences are annotated as yhfG however currently no function is known.. 
+PF10833 Protein of unknown function (DUF2572)<br>This bacterial family of proteins has no known function.. 
+PF10834 Protein of unknown function (DUF2560)<br>This family of proteins has no known function.. 
+PF10835 Protein of unknown function (DUF2573)<br>Some members in this bacterial family of proteins are annotated as YusU however no function is currently known. This family of proteins appears to be restricted to Bacillus spp.. 
+PF10836 Protein of unknown function (DUF2574)  <br>This family of proteins appears to be restricted to Enterobacteriaceae. Members of the family are annotated as yehE however currently no function is known.. 
+PF10837 Protein of unknown function (DUF2575)<br>This family of proteins appears to be restricted to Enterobacteriaceae. Members in the family are annotated as yaaY but currently there is no known function.. 
+PF10838 Protein of unknown function (DUF2677)<br>Members in this family of proteins are annotated as UL121 however currently no function is known.. 
+PF10839 Protein of unknown function (DUF2647)   <br>This eukaryotic family of proteins are annotated as ycf68 but have no known function.. 
+PF10840 Protein of unknown function (DUF2645)<br>This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YjeO however no function for this protein is currently known.. 
+PF10841 Protein of unknown function (DUF2644)<br>This family of proteins with unknown function appear to be restricted to Pasteurellaceae.. 
+PF10842 Protein of unknown function (DUF2642)<br>This family of proteins with unknown function appear to be restricted to Bacillus spp.. 
+PF10843 Protein of unknown function (DUF2578)<br>This is a Saccharomycete family of proteins with unknown function. The protein in S. cerevisiae is strongly induced in response to many stress conditions and is repressed in drug resistant yeast strains.. 
+PF10844 Protein of unknown function (DUF2577)<br>This family of proteins has no known function. 
+PF10845 Protein of unknown function (DUF2576)<br>The function of this viral family of proteins is unknown.. 
+PF10846 Protein of unknown function (DUF2722)<br>This eukaryotic family of proteins has no known function.. 
+PF10847 Protein of unknown function (DUF2656)<br>This bacterial family of proteins has no known function.. 
+PF10848 Protein of unknown function (DUF2655)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10849 Protein of unknown function (DUF2654)<br>Some members in this family of proteins are annotated as a-gt.4 however currently no function is known.. 
+PF10850 Protein of unknown function (DUF2653)<br>This family of proteins with unknown function appears to be restricted to Bacillus spp.. 
+PF10851 Protein of unknown function (DUF2652)   <br>This family of proteins has no known function.. 
+PF10852 Protein of unknown function (DUF2651)   <br>This family of proteins with unknown function appears to be restricted to Bacillus spp.. 
+PF10853 Protein of unknown function (DUF2650)<br>This family of proteins with unknown function appear to be restricted to Caenorhabditis elegans.. 
+PF10854 Protein of unknown function (DUF2649)<br>Members in this family of proteins are annotated as Plectrovirus orf 10 transmembrane proteins however currently no function is known.. 
+PF10855 Protein of unknown function (DUF2648)<br>This family of proteins with unknown function appears to be restricted to Bacillales Staphylococcus.. 
+PF10856 Protein of unknown function (DUF2678)<br>This family of proteins has no known function.. 
+PF10857 Protein of unknown function (DUF2701)<br>This viral family of proteins has no known function.. 
+PF10858 Protein of unknown function (DUF2659)<br>This bacterial family of proteins has no known function.. 
+PF10859 Protein of unknown function (DUF2660)<br>This is a family of proteins with unknown function.. 
+PF10860 Protein of unknown function (DUF2661)<br>This viral family of proteins have no known function.. 
+PF10861 Protein of Unknown function (DUF2784)<br>Gunasekaran P, Mistry J. Pfam-B_001600 (release 23.0). This is a family of uncharacterised protein. The function is not known however it is conserved in Bacteria.. 
+PF10862 DUF2662;<br>FcoT-like thioesterase domain. Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis   suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups  . The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.. 
+PF10863 Protein of unknown function (DUF2702)<br>This eukaryotic family of proteins has no known function.. 
+PF10864 Protein of unknown function (DUF2663)<br>Some members in this family of proteins are annotated as YpbF however currently no function is known.. 
+PF10865 Domain of unknown function (DUF2703)<br>This family of protein has no known function, but it may be distantly related to the thioredoxin fold. It contains the CXXC motif that is characteristic of thioredoxins.. 
+PF10866 Protein of unknown function (DUF2704)<br>This viral family of proteins has no known function.. 
+PF10867 Protein of unknown function (DUF2664)<br>This family of proteins is a viral family, annotated as UL96. Currently no function is known.. 
+PF10868 Protein of unknown function (DUF2667)<br>This family of proteins with unknown function appears to be restricted to Arabidopsis thaliana.. 
+PF10869 Protein of unknown function (DUF2666) <br>This Archaeal family of proteins has no known function.. 
+PF10870 Protein of unknown function (DUF2729)<br>This viral family of proteins has no known function.. 
+PF10871 Protein of unknown function (DUF2748)<br>This is a bacterial family of proteins with unknown function.. 
+PF10872 Protein of unknown function (DUF2740)<br>This family of proteins with unknown function has a highly conserved sequence.. 
+PF10873 Protein of unknown function (DUF2668)<br>Members in this family of proteins are annotated as Cysteine and tyrosine-rich protein 1, however currently no function is known.. 
+PF10874 Protein of unknown function (DUF2746)<br>This family of proteins has no known function.. 
+PF10875 Protein of unknown function (DUF2670)<br>This bacterial family of proteins has no known function.. 
+PF10876 Protein of unknown function (DUF2669)<br>This family of proteins has no known function.. 
+PF10877 Protein of unknown function (DUF2671)<br>This family of proteins with unknown function appears to be restricted to Rickettsia spp.. 
+PF10878 Protein of unknown function (DUF2672)<br>This family of proteins with unknown function appear to be restricted to Rickettsiae.. 
+PF10879 Protein of unknown function (DUF2674)<br>This family of proteins with unknown function appears to be conserved to Rickettsia spp.. 
+PF10880 Protein of unknown function (DUF2673)<br>This family of proteins with unknown function appears to be restricted to Rickettsiae spp.. 
+PF10881 Protein of unknown function (DUF2726)<br>This bacterial family of proteins has no known function.. 
+PF10882 DUF2679;<br>This family of proteins with unknown function appear to be related to bacterial PH domains. This family was formerly known as DUF2679.. 
+PF10883 Protein of unknown function (DUF2681)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 81 and 117 amino acids in length.. 
+PF10884 Protein of unknown function (DUF2683)<br>This family of proteins with unknown function appears to be restricted to Methanosarcinaceae.. 
+PF10885 Protein of unknown function (DUF2684)<br>Members in this family of proteins are annotated as yqgD however currently no function is known.. 
+PF10886 Protein of unknown function (DUF2685)<br>Members in this family of proteins are annotated as uvdY.-2 which is an open reading frame within uvsY. However currently there is no known function.. 
+PF10887 Protein of unknown function (DUF2686)<br>Some members in this family of proteins are annotated as yjfZ however currently no function is known.. 
+PF10888 Protein of unknown function (DUF2742)<br>Members in this family of phage proteins are the product of the gene phiRv1, however no function is known.. 
+PF10890 Protein of unknown function (DUF2741)<br>Members in this family of proteins are annotated as ubiquinol-cytochrome C reductase however this cannot be confirmed.. 
+PF10891 Protein of unknown function (DUF2719)<br>This family of proteins with unknown function appears to be restricted to Nucleopolyhedrovirus.. 
+PF10892 Protein of unknown function (DUF2688)<br>Members in this family of proteins are annotated as KleB however currently no function is known.. 
+PF10893 Protein of unknown function (DUF2724)<br>This is a family of proteins with unknown function.. 
+PF10894 Protein of unknown function (DUF2689)<br>Members in this family of proteins are annotated as TrbD however currently no function is known.. 
+PF10895 Protein of unknown function (DUF2715)<br>This family of proteins with unknown function appears to be restricted to Treponema pallidum.. 
+PF10896 Protein of unknown function (DUF2714)<br>This family of proteins with unknown function appears to be restricted to Mycoplasmataceae.. 
+PF10897 Protein of unknown function (DUF2713)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10898 Protein of unknown function (DUF2716)<br>This bacterial family of proteins has no known function.. 
+PF10899 Protein of unknown function (DUF2743)<br>This is a bacterial family of proteins with unknown function.. 
+PF10901 Protein of unknown function (DUF2690)<br>This bacterial family of proteins has no known function.. 
+PF10902 Protein of unknown function (DUF2693)<br>This viral family of proteins has no known function.. 
+PF10903 Protein of unknown function (DUF2691)<br>This bacterial family of proteins has no known function.. 
+PF10904 Protein of unknown function (DUF2694)<br>This family of proteins with unknown function appears to be restricted to Mycobacterium spp.. 
+PF10905 Protein of unknown function (DUF2695)<br>This bacterial family of proteins has no known function.. 
+PF10906 Protein of unknown function (DUF2697)<br>This is a eukaryotic family of proteins with unknown function.. 
+PF10907 Protein of unknown function (DUF2749)<br>This bacterial family of proteins appear to come from the Trb operon however currently no function is known.. 
+PF10908 Protein of unknown function (DUF2778)<br>Gunasekaran P, Mistry J. Pfam-B_001575 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF10909 Protein of unknown function (DUF2682)<br>This viral family of proteins has no known function.. 
+PF10910 Protein of unknown function (DUF2744)<br>This is a viral family of proteins with unknown function.. 
+PF10911 Protein of unknown function (DUF2717)<br>Members in this family of proteins are annotated as gene 6.5 protein however currently there is no known function.. 
+PF10912 Protein of unknown function (DUF2700)<br>This family of proteins with unknown function appears to be restricted to Caenorhabditis elegans.. 
+PF10913 Protein of unknown function (DUF2706)<br>This family of proteins with unknown function appears to be restricted to Rickettsia spp.. 
+PF10914 Protein of unknown function (DUF2781)<br>Gunasekaran P, Mistry J. Pfam-B_001738 (release 23.0). This is a eukaryotic family of uncharacterised proteins.  Some of the proteins in this family are annotated as membrane proteins.. 
+PF10915 Protein of unknown function (DUF2709)<br>This bacterial family of proteins has no known function.. 
+PF10916 Protein of unknown function (DUF2712)<br>This family of proteins with unknown function appear to be restricted to Bacillales.. 
+PF10917 Protein of unknown function (DUF2708)<br>This family of proteins with unknown function appears to be restricted to Caenorhabditis elegans.. 
+PF10918 Protein of unknown function (DUF2718)<br>This viral family of proteins has no known function.. 
+PF10920 Protein of unknown function (DUF2705)<br>This bacterial family of proteins has no known function.. 
+PF10921 Protein of unknown function (DUF2710)<br>This family of proteins with unknown function appears to be restricted to Mycobacteriaceae.. 
+PF10922 Protein of unknown function (DUF2745)<br>This is a viral family of proteins with unknown function.. 
+PF10923 P-loop Domain of unknown function (DUF2791)<br>Gunasekaran P, Mistry J. Pfam-B_001611 (release 23.0). This is a family of proteins found in archaea and bacteria. This domain contains a P-loop motif suggesting it binds to a nucleotide such as ATP.. 
+PF10924 Protein of unknown function (DUF2711)<br>Some members in this family of proteins are annotated as ywbB however currently there is no known function.. 
+PF10925 Protein of unknown function (DUF2680)<br>Members in this family of proteins are annotated as yckD however currently no function is known.. 
+PF10926 Protein of unknown function (DUF2800)<br>Gunasekaran P, Mistry J. Pfam-B_001630 (release 23.0). This is a family of uncharacterised proteins found in bacteria and viruses. Some members of this family are annotated as being Phi APSE P51-like proteins.. 
+PF10927 Protein of unknown function (DUF2738)<br>This is a viral family of proteins with unknown function.. 
+PF10928 Protein of unknown function (DUF2810)<br>Gunasekaran P, Mistry J. Pfam-B_001682 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF10929 Protein of unknown function (DUF2811)<br>Gunasekaran P, Mistry J. Pfam-B_001693 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF10930 Protein of unknown function (DUF2737)<br>This family of proteins has no known function.. 
+PF10931 Protein of unknown function (DUF2735)<br>Some members in this family of proteins are annotated as glutamine synthetase translation inhibitor however this function can not be confirmed.. 
+PF10932 Protein of unknown function (DUF2783)<br>Gunasekaran P, Mistry J. Pfam-B_001590 (release 23.0). This is a bacterial family of uncharacterised protein.. 
+PF10933 Protein of unknown function (DUF2827)<br>Gunasekaran P, Mistry J. Pfam-B_001771 (release 23.0). This is a family of uncharacterised proteins found in Burkholderia.. 
+PF10934 Protein of unknown function (DUF2634)<br>Some members in this family of proteins are annotated as phage related, xkdS however currently there is no known function.. 
+PF10935 Protein of unknown function (DUF2637)<br>This family of proteins has no known function.. 
+PF10936 Protein of unknown function DUF2617<br>This bacterial family of proteins has no known function.  . 
+PF10937 Protein of unknown function (DUF2638)<br>This family of proteins has no known function.. 
+PF10938 YfdX protein<br>YfdX is a protein found in Proteobacteria of unknown function. The protein coding for this gene is regulated by EvgA in E. coli  .. 
+PF10939 Protein of unknown function (DUF2631)   <br>This is s bacterial family of proteins with unknown function.. 
+PF10940 Protein of unknown function (DUF2618)<br>This bacterial family of proteins has no known function. The sequences within the family are highly conserved.. 
+PF10941 Protein of unknown function DUF2620<br>This is a bacterial family of proteins with unknown function.. 
+PF10942 Protein of unknown function (DUF2619)<br>This bacterial family of proteins has no known function.. 
+PF10943 Protein of unknown function (DUF2632)<br>This is a family of membrane proteins with unknown function.. 
+PF10944 Protein of unknown function (DUF2630)<br>This bacterial family of proteins have no known function.. 
+PF10945 Protein of unknown function (DUF2629)<br>Some members in this family of proteins are annotated as yhjR however currently no function is known.. 
+PF10946 Protein of unknown function DUF2625<br>Some members in this family of proteins are annotated as ybfG however currently no function is known.. 
+PF10947 Protein of unknown function (DUF2628)    <br>Some members in this family of proteins are annotated as yigF however currently no function is known.. 
+PF10948 Protein of unknown function (DUF2635)<br>This is a family of phage proteins with unknown function.. 
+PF10949 Protein of unknown function (DUF2777)<br>This family of proteins with unknown function appears to be restricted to Bacillus cereus.. 
+PF10950 Protein of unknown function (DUF2775)<br>This eukaryotic family of proteins has no known function.. 
+PF10951 Protein of unknown function (DUF2776)<br>This bacterial family of proteins has no known function.. 
+PF10952 Protein of unknown function (DUF2753)<br>This bacterial family of proteins has no known function.. 
+PF10953 Protein of unknown function (DUF2754)<br>This family of proteins with unknown function appear to be restricted to Enterobacteriaceae.. 
+PF10954 Protein of unknown function (DUF2755)<br>Some members in this family of proteins are annotated as YaiY however no function is known. The family appears to be restricted to Enterobacteriaceae.. 
+PF10955 Protein of unknown function (DUF2757)<br>Members in this family of proteins are annotated as YabK however currently no function is known.. 
+PF10956 Protein of unknown function (DUF2756)<br>Some members in this family of proteins are annotated yhhA however currently no function is known. The family appears to be restricted to Enterobacteriaceae.. 
+PF10957 Protein of unknown function (DUF2758)<br>This family of proteins has no known function.. 
+PF10958 Protein of unknown function (DUF2759)<br>This family of proteins with unknown function appear to be restricted to Bacillaceae.. 
+PF10959 Protein of unknown function (DUF2761)<br>Members in this family of proteins are annotated as KleF however no function is known.. 
+PF10960 Protein of unknown function (DUF2762)<br>Members in this family of proteins are annotated as holin-like protein BhlA however this cannot be confirmed.. 
+PF10961 Protein of unknown function (DUF2763)<br>This eukaryotic family of proteins has no known function.. 
+PF10962 Protein of unknown function (DUF2764)<br>This bacterial family of proteins has no known function.. 
+PF10963 Protein of unknown function (DUF2765)<br>This family of proteins has no known function.. 
+PF10964 Protein of unknown function (DUF2766)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10965 Protein of unknown function (DUF2767)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10966 Protein of unknown function (DUF2768)<br>This family of proteins with unknown function appear to be restricted to Bacillus spp.. 
+PF10967 Protein of unknown function (DUF2769)<br>This family of proteins have no known function.. 
+PF10968 Protein of unknown function (DUF2770)<br>Members in this family of proteins are annotated as yceO however currently no function is known.. 
+PF10969 Protein of unknown function (DUF2771)<br>This bacterial family of proteins has no known function.. 
+PF10970 Protein of unknown function (DUF2772)<br>Members in this family of proteins are annotated as spore germination protein GE however this cannot be confirmed.. 
+PF10971 Protein of unknown function (DUF2773)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF10972 Protein of unknown function (DUF2803)<br>Pfam-B_1049 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF10973 Protein of unknown function (DUF2799)<br>Pfam-B_1111 (release 23.0). Some members in this family of proteins are annotated as yfiL which has no known function.. 
+PF10974 Protein of unknown function (DUF2804)<br>Pfam-B_1045 (release 23.0). This is a family of proteins with unknown function.. 
+PF10975 Protein of unknown function (DUF2802)<br>Pfam-B_1126 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10976 Protein of unknown function (DUF2790)<br>Pfam-B_1206 (release 23.0). This family of proteins with unknown function appear to be restricted to Pseudomonadaceae.. 
+PF10977 Protein of unknown function (DUF2797)<br>Pfam-B_1162 (release 23.0). This family of proteins has no known function.. 
+PF10978 Protein of unknown function (DUF2785)<br>Pfam-B_1219 (release 23.0). Some members in this family are annotated as hypothetical membrane spanning proteins however this cannot be confirmed. The family has no known function.. 
+PF10979 Protein of unknown function (DUF2786)<br>Pfam-B_1231 (release 23.0). This family of proteins has no known function.. 
+PF10980 Protein of unknown function (DUF2787)<br>Pfam-B_1249 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10981 Protein of unknown function (DUF2788)<br>Pfam-B_1255 (release 23.0). This bacterial family of proteins have no known function.. 
+PF10982 Protein of unknown function (DUF2789)<br>Pfam-B_1269 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10983 Protein of unknown function (DUF2793)<br>Pfam-B_1370 (release 23.0). This is a bacterial family of proteins with unknown function.. 
+PF10984 Protein of unknown function (DUF2794)<br>Pfam-B_1384 (release 23.0). This is a bacterial family of proteins with unknown function.. 
+PF10985 Protein of unknown function (DUF2805)<br>Pfam-B_001474 (release 23.0). This is a bacterial family of proteins with unknown function.. 
+PF10986 Protein of unknown function (DUF2796)<br>Pfam-B_1354 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10987 Protein of unknown function (DUF2806)<br>Pfam-B_001505 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10988 Protein of unknown function (DUF2807)<br>Pfam-B_001516 (release 23.0). This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In PDB:3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two.  It seems likely that this family belongs to the superfamily of trimeric autotransporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens    .  In the case of Parabacteroides distasonis, which is a cmoponent of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).. 
+PF10989 Protein of unknown function (DUF2808)<br>Pfam-B_001529 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF10990 Protein of unknown function (DUF2809)<br>Pfam-B_001533 (release 23.0). Some members in this family of proteins are annotated as yjgA however currently no function for the protein is known.. 
+PF10991 Protein of unknown function (DUF2815)<br>Pfam-B_002212 (release 23.0). This is a phage related family of proteins with unknown function.. 
+PF10992 Protein of unknown function (DUF2816)<br>Pfam-B_002257 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF10993 Protein of unknown function (DUF2818)<br>Pfam-B_002280 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10994 Protein of unknown function (DUF2817)<br>Pfam-B_002258 (release 23.0). This family of proteins has no known function.. 
+PF10995 Protein of unknown function (DUF2819)<br>Pfam-B_002304 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10996 Beta-Casp domain<br>The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease.  The active site of this enzyme is located at the interface of these two domains  .. 
+PF10997 Protein of unknown function (DUF2837)<br>Pfam-B_002349 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10998 Protein of unknown function (DUF2838)<br>Pfam-B_002381 (release 23.0). This bacterial family of proteins has no known function.. 
+PF10999 Protein of unknown function (DUF2839)<br>Pfam-B_002396 (release 23.0). This bacterial family of unknown function appear to be restricted to Cyanobacteria.. 
+PF11000 Protein of unknown function (DUF2840)<br>Pfam-B_002399 (release 23.0). This bacterial family of proteins have no known function.. 
+PF11001 Protein of unknown function (DUF2841)<br>Pfam-B_002409 (release 23.0). This family of proteins with unknown function are all present in yeast.. 
+PF11002 RFPL defining motif (RDM)<br>Mistry J, Bonnefont J. The RDM domain is found on RFPL (Ret finger protein like) proteins.  In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex  .  The RDM domain is thought to have emerged from a neofunctionalisation event.  It is found N terminal to the SPRY domain (Pfam:PF00622).. 
+PF11003 Protein of unknown function (DUF2842)<br>Pfam-B_002411 (release 23.0). This bacterial family of proteins have no known function.. 
+PF11004 DUF2843;<br>3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase. Pfam-B_002426 (release 23.0). This is a family of 3-deoxy-D-manno-oct-2-ulosonic acid 3-hydroxylases, which catalyse the conversion of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) to D-glycero-D-talo-oct-2-ulosonic acid (Ko). It contains a potential iron-binding motif, HXDX(n)H (n>40). Hydroxylation activity is iron-dependent  .. 
+PF11005 Protein of unknown function (DUF2844)<br>Pfam-B_002433 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11006 Protein of unknown function (DUF2845)<br>Pfam-B_002437 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11007 Spore coat associated protein JA (CotJA)<br>CotJA is part of the CotJ operon which contains CotJA and CotJC. The operon encodes spore coat proteins. Interaction of CotJA with CotJC is required for the assembly of both CotJA and CotJC into the spore coat  .. 
+PF11008 Protein of unknown function (DUF2846)<br>Pfam-B_002451 (release 23.0). Some members in this family of proteins with unknown function are annotated as lipoproteins however this cannot be confirmed.. 
+PF11009 Protein of unknown function (DUF2847)<br>Pfam-B_002453 (release 23.0). Some members in this bacterial family of proteins with unknown function are annotated as YtxJ, a putative general stress protein. This cannot be confirmed.. 
+PF11010 Protein of unknown function (DUF2848)<br>Pfam-B_002463 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11011 Protein of unknown function (DUF2849)<br>Pfam-B_002560 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11012 Protein of unknown function (DUF2850)<br>Pfam-B_002587 (release 23.0). This family of proteins with unknown function appear to be restricted to Vibrionaceae.. 
+PF11013 Protein of unknown function (DUF2851)<br>Pfam-B_002589 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11014 Protein of unknown function (DUF2852)<br>Pfam-B_002611 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11015 Protein of unknown function (DUF2853)<br>Pfam-B_002619 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11016 Protein of unknown function (DUF2854)<br>Pfam-B_002643 (release 23.0). This family of proteins has no known function.. 
+PF11017 Protein of unknown function (DUF2855)<br>Pfam-B_002665 (release 23.0). This family of proteins has no known function.. 
+PF11018 Pupal cuticle protein C1<br>Insect cuticles are composite structures whose mechanical properties are optimised for biological function.  The major components are the chitin filament system and the cuticular proteins, and the cuticle's properties are determined largely by the interactions between these two sets of molecules. The proteins can be ordered by species.. 
+PF11019 Protein of unknown function (DUF2608)<br>This family is conserved in Bacteria. The function is not known.. 
+PF11020 Domain of unknown function (DUF2610)<br>This family is conserved in Proteobacteria. One member is annotated as being elongation factor P but this could not be confirmed. This domain is related to the Ribbon-helix-helix superfamily so may be a DNA-binding protein.. 
+PF11021 Protein of unknown function (DUF2613)<br>This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.. 
+PF11022 Protein of unknown function (DUF2611)<br>This family is conserved in the Dikarya of Fungi. The function is not known.. 
+PF11023 Protein of unknown function (DUF2614)<br>This is a family of proteins conserved in the Bacillaceae family. Some members are annotated as being protein YgzB. The function is not known.. 
+PF11024 Dispersed gene family protein 1 of Trypanosoma cruzi region 4<br>Pfam-B_187 (release 23.0). This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known. Other domains on this protein include DGF-1_N, DGF-1_2, and DGF-1_5. This domain is just downstream from the C-terminus, but not the C-terminus of proteins, also annotated as being DGF-1, that constitute family DGF-1_C.. 
+PF11025 Glycoprotein GP40 of Cryptosporidium<br>Pfam-B_197 (release 23.0). This family is highly conserved in Cryptosporidium spp.  Many members are annotated as being a 60 kDa glycoprotein.. 
+PF11026 Protein of unknown function (DUF2721)<br>Pfam-B_520 (release 23.0). This family is conserved in bacteria. The function is not known.. 
+PF11027 Protein of unknown function (DUF2615)<br>This small. approximately 100 residue, family is conserved from worms to humans. It is cysteine-rich with a characteristic FDxCEC sequence motif. The function is not known.. 
+PF11028 Protein of unknown function (DUF2723)<br>Pfam-B_590 (release 23.0). This family is conserved in bacteria.  The function is not known.. 
+PF11029 DAZ associated protein 2 (DAZAP2)<br>DAZ associated protein 2 has a highly conserved sequence throughout evolution including a conserved polyproline region and several SH2/SH3 binding sites. It occurs as a single copy gene with a four-exon organisation and is located on chromosome 12. It encodes a ubiquitously expressed protein and binds to DAZ and DAZL1 through DAZ repeats [1,2].. 
+PF11030 Nucleocapsid protein N   <br>This is the N protein of the nucleocapsid. The nucleocapsid functions to protect the RNA against nuclease degradation and to promote it's reverse transcription  . The NC protein promotes viral RNA dimerisation and encapsidation and initiates reverse transcription by activating the annealing of the primer tRNA to the initiation site  .. 
+PF11031 Bacteriophage T holin<br>Bacteriophage effects host lysis with T holin along with an endolysin. T disrupts the membrane allowing sequential events which lead to the attack of the peptidoglycan. T has an usual periplasmic domain which transduces environmental information for the real-time control of lysis timing  .. 
+PF11032 Apolipoprotein M (ApoM)<br>ApoM is a 25 kDa plasma protein associated with high-density lipoproteins (HDLs). ApoM is important in the formation of pre-ss-HDL and also in increasing cholesterol efflux from macrophage foam cells  . Lipoproteins consist of lipids solubilized by apolipoproteins. ApoM lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide  .. 
+PF11033 Competence protein J (ComJ)<br>ComJ is a competence specific protein  .. 
+PF11034 Protein of unknown function (DUF2823)<br>This family of proteins are possible glucose repressible proteins however this cannot be confirmed. Currently, no function is known.. 
+PF11035 Small nuclear RNA activating complex subunit 2-like<br>This family of proteins is SnAPC subunit 2-like. SnAPC allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element  .. 
+PF11036 Virulence promoting factor<br>YqgB encodes adaptive factors that acts in synergy with vqfZ , enabling the bacteria to cope with the physical environment in vivo, facilitating colonisation of the host  .. 
+PF11037 Insulin-resistance promoting peptide in skeletal muscle<br>Musclin is a muscle derived secretory peptide which induces insulin resistance in vitro. It encodes a 130 amino acid sequence including a NH(2) terminal 30 amino acid signal sequence. Musclin expression level is tightly regulated by nutritional changes [1,2].. 
+PF11038 Dispersed gene family protein 1 of Trypanosoma cruzi region 5<br>Pfam-B_157 (release 23.0). This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known.  Other domains on this protein include DGF-1_N, DGF-1_2, and DGF-1_4. This domain is just downstream from the C-terminus, but not the C-terminus of proteins, also annotated as being DGF-1, that constitute family DGF-1_C.. 
+PF11039 Protein of unknown function (DUF2824)<br>This family of proteins has no known function. Some members in the family are annotated as the P22 head assembly protein gp14 however this cannot be confirmed.. 
+PF11040 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus <br>Pfam-B_30 (release 23.0). This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known. This is the very C-terminal part of the protein.. 
+PF11041 Protein of unknown function (DUF2612)<br>This is a phage protein family expressed from a range of Proteobacteria species. The function is not known.. 
+PF11042 Protein of unknown function (DUF2750)<br>Pfam-B_609 (release 23.0). This family is conserved in Proteobacteria. The function is not known.. 
+PF11043 Protein of unknown function (DUF2856)<br>Some members in this viral family of proteins with unknown function are annotated as Abc2 however this cannot be confirmed.. 
+PF11044 Plectrovirus spv1-c74 ORF 12 transmembrane protein<br>This is a family of proteins expressed by Plectroviruses. The plectroviruses are single-stranded DNA viruses belonging to the Inoviridae. Except that it is a putative transmembrane protein the function is not known.. 
+PF11045 Putative inner membrane protein of Enterobacteriaceae<br>This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.. 
+PF11046 Transcriptional repressor of hyc and hyp operons<br>This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction  .. 
+PF11047 Salmonella outer protein D<br>SopD is a type III virulence effector protein whose structure consists of 38% alpha-helix and 26% beta-strand.. 
+PF11049 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus<br>Pfam-B_38 (release 23.0). This is a highly glycosylated cytoplasmic and membrane protein similar to the immunoglobulin receptor family that is expressed as an inducible early-lytic-cycle gene product in primary effusion lymphoma cell-lines. This domain would appear to be the cytoplasmic region of the protein  .. 
+PF11050 Virus envelope protein E26<br>E26 is a multifunctional protein. One form of E26 associates with viral DNA or DNA binding proteins, while a second form associates with intracellular membranes  .. 
+PF11051 Mannosyltransferase putative<br>Pfam-B_379 (release 23.0). This family is conserved in fungi. Several members are annotated as being alpha-1,3-mannosyltransferase but this could not be confirmed.. 
+PF11052 Trans-sialidase of Trypanosoma hydrophobic C-terminal<br>Pfam-B_103 (release 23.0). This is a highly conserved sequence motif that is the very C-terminus of a number of more diverse proteins from Trypanosoma cruzi. All members of the family are annotated putatively as being trans-sialidase but this appears to be a diverse group.. 
+PF11053 Terminase DNA packaging enzyme<br>Phage T4 terminase functions in packaging concatemeric DNA. The T4 terminase is composed of a large subunit, gp17 ad a small subunit, gp16. The role of gp16 is not well characterised however it is known that it binds to double-stranded DNA but not single stranded DNA  .. 
+PF11054 Sporozoite TA4 surface antigen<br>This family of proteins is a Eukaryotic family of surface antigens. One of the better characterised members of the family is the sporulated TA4 antigen. The TA4 gene encodes a single polypeptide of 25 kDa which contains a 17 and a 8 kD polypeptide  .. 
+PF11055 Glucose signalling factor 2<br>Gsf2 is localised to the ER and functions to promote the secretion of certain hexose transporters  .. 
+PF11056 Recombination, repair and ssDNA binding protein UvsY<br>UvsY protein enhances the rate of single-stranded-DNA-dependant ATP hydrolysis by UvsX protein. The enhancement of ATP hydrolysis by UvsY protein is shown to result from the ability of UvsY protein to increase the affinity of UvsX protein for single-stranded DNA  .. 
+PF11057 Cortexin of kidney<br>In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species  . Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex  .. 
+PF11058 Antirestriction protein Ral <br>Ral alleviates restriction and enhances modification by the E.Coli restriction and modification system  .. 
+PF11059 Protein of unknown function (DUF2860)<br>Pfam-B_002667 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11060 Protein of unknown function (DUF2861)<br>Pfam-B_002683 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11061 Protein of unknown function (DUF2862)<br>Pfam-B_003005 (release 23.0). This family of proteins has no known function.. 
+PF11062 Protein of unknown function (DUF2863)<br>Pfam-B_002981 (release 23.0). This bacterial family of proteins have no known function.. 
+PF11064 Protein of unknown function (DUF2865)<br>Pfam-B_002953 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11065 Protein of unknown function (DUF2866)<br>Pfam-B_002950 (release 23.0). This bacterial family of proteins have no known function.. 
+PF11066 Protein of unknown function (DUF2867)<br>Pfam-B_002931 (release 23.0). This bacterial family of proteins have no known function.. 
+PF11067 Protein of unknown function (DUF2868)<br>Pfam-B_002930 (release 23.0). Some members in this family of proteins with unknown function are annotated as putative membrane proteins. However, this cannot be confirmed.. 
+PF11068 DUF2869;<br>Pfam-B_002915 (release 23.0). The structure of a representative of this family has been solved (pdb:4dci) and found to form a tetrameric structure of prefoldin-like architecture with the beta-barrel core and helical coiled coil tentacles. This suggests that this family may act as molecular chaperones.. 
+PF11069 Protein of unknown function (DUF2870)<br>Pfam-B_002904 (release 23.0). This is a eukaryotic family of proteins with unknown function.. 
+PF11070 Protein of unknown function (DUF2871)<br>Pfam-B_002884 (release 23.0). This family of proteins has no known function.. 
+PF11071 Protein of unknown function (DUF2872)<br>Pfam-B_002883 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11072 Protein of unknown function (DUF2859)<br>Gunasekaran P, Mistry J. Pfam-B_001915 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11073 Rift valley fever virus non structural protein (NSs) like <br>Gunasekaran P, Mistry J. Pfam-B_001643 (release 23.0). This family contains several Phlebovirus non structural proteins which act as a major determinant of virulence by antagonising interferon beta gene expression  .. 
+PF11074 Domain of unknown function(DUF2779)<br>Gunasekaran P, Mistry J. Pfam-B_001581 (release 23.0). This domain is conserved in bacteria. The function is not known.. 
+PF11075 Protein of unknown function VcgC/VcgE (DUF2780)<br>Gunasekaran P, Mistry J. Pfam-B_001695 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11076 Putative inner membrane protein YbhQ<br>This family is conserved in Proteobacteria. The function is not known but most members are annotated as being inner membrane protein YbhQ.. 
+PF11077 Protein of unknown function (DUF2616)<br>This cysteine-rich family is expressed by the double-stranded Nucleopolyhedrovirus, a member of the Baculoviridae family of dsDNA viruses.  The function is not known.. 
+PF11078 Optomotor-blind protein N-terminal region<br>Pfam-B_595 (release 23.0). This family is conserved in Drosophila spp. Optomotor-blind is one of the essential toolkit proteins for coordinating development in diverse animal taxa, and in Drosophila it plays a key role in establishing the abdominal pigmentation pattern, in development of the central nervous system and leg and wing imaginal disc-formation of Drosophila melanogaster. This is the N-terminal region of the protein and does not include the T-box-containing transcription factor that plays a part in DNA-binding.. 
+PF11079 Bacterial protein YqhG of unknown function<br>This family of putative proteins is conserved in the Bacillaceae family of the Firmicutes. The function is not known.. 
+PF11080 Protein of unknown function (DUF2622)<br>This family is conserved in the Enterobacteriaceae family. Several members are named as YdiZ, a putative cytoplasmic protein. The function is not known.. 
+PF11081 Protein of unknown function (DUF2890)<br>Pfam-B_629 (release 23.0). This family is conserved in dsDNA adenoviruses of vertebrates. The function is not known.. 
+PF11082 Protein of unknown function (DUF2880)<br>Pfam-B_001492 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11083 Lantibiotic streptin immunity protein<br>Pfam-B_43518 (release 22.0). Streptococcal species produce a lantibiotic, streptin, in a similar manner to the production of nisin and subtilin by other lactic acid bacteria, in order to compete against competing bacteria within the environment. The immunity protein protects the bacterium from destruction by its own lantibiotic. In general, there is little homology between the immunity proteins of different genera of bacteria.. 
+PF11084 Protein of unknown function (DUF2621)<br>Mistrey J, Coggill P. This family is conserved in the Bacillaceae family.  Several members are named as YneK. The function is not known.. 
+PF11085 Conserved membrane protein YqhR<br>This family is conserved in the Bacillaceae family of the Firmicutes. The function is not known.. 
+PF11086 Protein of unknown function (DUF2878)<br>Pfam-B_001539 (release 23.0). This bacterial family of proteins has no known function. Some members annotate the proteins as the permease component of a Mn2+/Zn2+ transport system however this cannot be confirmed.. 
+PF11087 Protein of unknown function (DUF2881)<br>This viral family of proteins has no known function. Some members are annotated as p34 however this cannot be confirmed.. 
+PF11088 Glycoprotein encoding membrane proteins RL5A and RL6<br>RL5A and RL6 are part of the RL11 family which are predicted to encode membrane glycoproteins. Two adjacent open reading frames potentially encode a domain that is the hallmark of proteins encoded by the RL11 family.. 
+PF11089 Exopolysaccharide production repressor<br>SyrA is a small protein located in the cytoplasmic membrane that lacks an apparent DNA binding domain. SyrA mediates the transcriptional up-regulation of exo genes involved in the biosynthesis of the symbiotic exopolysaccharide succinoglycan. It does this through a mechanism which requires a two component system  .. 
+PF11090 Protein of unknown function (DUF2833)<br>This family of proteins with unknown function are found in the bacteriophage T7. Some of the members of this family are annotated as gene 13 protein.. 
+PF11091 Tail-tube assembly protein<br>This tail tube protein is also referred to as Gp48. It is required for the assembly and length regulation of the tail tube of bacteriophage T4  .. 
+PF11092 Neuronal protein 3.1 (p311)<br>P311 has several PEST-like motifs and is found in neuron and muscle cells. P311 could have some function in myo-fibroblast transformation and prevention of fibrosis  . It has also been identified as a potential regulator of alveolar generation  .. 
+PF11093 Mitochondrial export protein Som1<br>Som1 is a component of the mitochondrial protein export system. The various Som1 proteins exhibit a highly conserved region and a pattern of cysteine residues  . Stabilisation of Som1 occurs through an interaction between Som1 and Imp1, a peptidase required for proteolytic processing of certain proteins during their transport across the mitochondrial membrane  . This suggests that Som1 represents a third subunit of the Imp1 peptidase complex  . 
+PF11094 Membrane-associated tegument protein<br>The UL11 gene product of herpes simplex virus is a membrane-associated tegument protein that is incorporated into the HSV virion and functions in viral envelopment  . UL11 is acylated which is crucial for lipid raft association  .. 
+PF11095 Gem-associated protein 7 (Gemin7)<br>Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE  .. 
+PF11097 Protein of unknown function (DUF2883)<br>This family of proteins have no known function but appear to be restricted to phage.. 
+PF11098 Chlorosome envelope protein C<br>Chlorosomes are light-harvesting antennae found in green bacteria. CsmC is one of the proteins that exists in the chlorosome envelope. CsmC has been shown to exist as a homomultimer with CsmD in the chlorosome envelope  . CsmC is thought to be important in chlorosome elongation and shape  .. 
+PF11099 Apoptosis regulator M11L like<br>Apoptosis regulators function to modulate the apoptotic cascades and thereby favour productive viral replication. M11L inhibits mitochondrial-dependant apoptosis by mimicking and competing with host proteins for the binding and blocking of Bak and Bax, two executioner proteins  .. 
+PF11100 Conjugal transfer protein TrbE <br>TrbE is essential for conjugation and phage adsorption. It contains four common motifs and one conserved domain  .. 
+PF11101 Protein of unknown function (DUF2884)<br>Pfam-B_001481 (release 23.0). Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.. 
+PF11102 DUF2886; Cap_synth_GfcC;<br>Group 4 capsule polysaccharide formation lipoprotein gfcB. Pfam-B_1366 (release 23.0). This family includes lipoprotein GfcB (YmcC), involved in group 4 capsule polysaccharide formation  .. 
+PF11103 Protein of unknown function (DUF2887)<br>Pfam-B_1330 (release 23.0). This bacterial family of proteins has no known function. These proteins may be distantly related to the PD(D/E)XK superfamily.. 
+PF11104 Competence_A;<br>Type IV pilus assembly protein PilM;. The type IV pilus assembly protein PilM is required for competency and pilus biogenesis [1-2]. It binds to PilN and ATP  .. 
+PF11105 Arthropod cardioacceleratory peptide 2a<br>CCAP exerts a reversible and dose-dependant cardio-stimulatory effect on the semi-isolated heart of experimental beetles. CCAP also increases free hemolymph sugar concentration in young larvae and adults of the meal-worm beetle  .. 
+PF11106 Exopolysaccharide production protein YjbE<br>YjbE is part of a four gene operon which is involved in exopolysaccharide production. The expression of YjbE is higher than the rest of the operon yjbEFGH. It appears to be restricted to Enterobacteriaceae  .. 
+PF11107 Fanconi anemia group F protein (FANCF)<br>FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway  .. 
+PF11108 Viral glycoprotein L<br>GL forms a complex with gH, a glycoprotein known to be essential for entry of HSV-1 into cells and virus-induced cell fusion  . It is a hetero-oligomer of gH and gL which is incorporated into virions and transported to the cell surface which acts during entry of virus into cells  . 
+PF11109 Orexigenic neuropeptide Qrfp/P518 <br>Qrfp/P518 has a direct role in maintaining bone mineral density  . Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice  . The c-terminal 28 residues are the functional 26RFa  .. 
+PF11110 Baseplate hub distal subunit<br>These baseplate proteins are also referred to as Gp28. Gp28 is the structural component of the central part of the bacteriophage T4 baseplate, which possesses a hydrophobic region and is membrane bound  . Gp28 forms a complex with gp27 which is another structural component of the baseplate  .. 
+PF11111 Centromere protein M (CENP-M)<br>The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A  . CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins  . Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival  .. 
+PF11112 Pyocin activator protein PrtN<br>PrtN is a transcriptional activator for pyocin synthesis genes  . It activates the expression of various pyocin genes by interaction with the DNA sequences conserved in the 5' noncoding regions of the pyocin genes  .. 
+PF11113 Head assembly gene product<br>This head assembly protein is also refereed to as gene product 40 (Gp40). A specific gp20-gp40 membrane insertion structure constitutes the T4 prohead assembly initiation complex  . This protein in T4 stimulates head formation  .. 
+PF11114 Minor_capsid; Minor_capsid-2;<br>Minor capsid protein. Most of the members of this family are annotated as being minor capsid proteins. The genomes carrying the genes usually have three similar proteins adjacent to each other, hence this one being named as No.2.. 
+PF11115 Protein of unknown function (DUF2623)<br>This family is conserved in the Enterobacteriaceae family. Several members are named as YghW. The function is not known.. 
+PF11116 Protein of unknown function (DUF2624)<br>This family is conserved in the Bacillaceae family.  Several members are named as YqfT. The function is not known.. 
+PF11117 Protein of unknown function (DUF2626)<br>This family is conserved in the Bacillaceae family.  Several members are named as YqgY. The function is not known.. 
+PF11118 Protein of unknown function (DUF2627)<br>This family is conserved in the Bacillaceae family.  Several members are named as YqzF. The function is not known.. 
+PF11119 Protein of unknown function (DUF2633)<br>This family is conserved largely in the Bacillaceae family. Several members are named as YfgG. The function is not known.. 
+PF11120 Protein of unknown function (DUF2636)<br>This family is conserved in the Enterobacteriaceae family. Several members are named as being YhjT, but the function is not known.. 
+PF11121 Protein of unknown function (DUF2639)<br>This family is conserved in the Bacillaceae family.  Several members are named as being YflJ, but the function is not known.. 
+PF11122 Inner spore coat protein D<br>This family is conserved in the Enterobacteriaceae family. CotD is an inner spore coat protein that is expressed in the middle phase of mother cell gene expression. Along with CotD, CotH, CotS and CotT it is assumed to assemble into the loose skeleton of the matrix, between the shells of SpoIVA and CotE. Coat proteins do not share much sequence similarity between species, but this does not imply they do not share secondary, tertiary, or quaternary features  .. 
+PF11123 DNA packaging protein <br>This DNA packaging protein is also referred to as gene 18 product (gp18). This protein is required for DNA packaging and functions in a complex with gp19  .. 
+PF11124 Inorganic phosphate transporter Pho86<br>Pho86p is an ER protein which is produced in response to phosphate starvation. It is essential for growth when phosphate levels are limiting  . Pho86p is also involved in the regulation of Pho84p, a high-affinity phosphate transporter which is localised to the endoplasmic reticulum (ER) in low phosphate medium. When the level of phosphate increases Pho84p is transported to the vacuole. Pho86p is required for packaging of Pho84p in to COPII vesicles  .. 
+PF11125 Protein of unknown function (DUF2830)<br>Several members in this viral family of proteins are annotated as lysis proteins.. 
+PF11126 Transcriptional regulator DsbA<br>DsbA is a double stranded binding protein found in bacteriophage T4 which is involved in transcriptional regulation. DsbA, along with other viral proteins, interacts with the host RNA polymerase core enzyme enabling initiation of transcription. DsbA acts as an enhancer protein of late genes in vitro. The protein consists of mainly alpha helices  .. 
+PF11127 Protein of unknown function (DUF2892)<br>Pfam-B_604 (release 23.0). This family is conserved in bacteria. The function is not known.. 
+PF11128 Plant viral coat protein nucleocapsid<br>Pfam-B_645 (release 23.0). This family of nucleocapsid proteins is from ssRNA negative-strand viruses of plant origin.. 
+PF11129 Rev protein of equine infectious anaemia virus<br>Pfam-B_124 (release 23.0). The sequence of this family is highly conserved and carries a nuclear export signal from residues 31-55, and RNA binding/nuclear localisation signals of RRDR at residue 76 and KRRRK at residue 159. Rev is an essential regulatory protein required for nucleocytoplasmic transport of incompletely spliced viral mRNAs that encode structural proteins. Rev has been shown to down-regulate the expression of viral late genes and alter sensitivity to Gag-specific cytotoxic-T-lymphocytes (CTL). Equine infectious anaemia virus (EIAV) exhibits a high rate of genetic variation in vivo, and results in a clinically variable disease in infected horses.. 
+PF11130 F pilus assembly Type-IV secretion system for plasmid transfer<br>Pfam-B_678 (release 23.0). This family of TraC proteins is conserved in Proteobacteria. TraC is a cytoplasmic, peripheral membrane protein and is one of the proteins encoded by the F transfer region of the conjugative plasmid that is required for the assembly of F pilin into the mature F pilus structure. F pili are filamentous appendages that help establish the physical contact between donor and recipient cells involved in the conjugation process  .. 
+PF11131 Rap-phr extracellular signalling<br>PhrC and PhrF stimulate ComA-dependent gene expression to different levels and are both required for full expression of genes activated by ComA, which activates the expression of genes involved in competence development and the production of several secreted products  .. 
+PF11132 Transcriptional regulator protein (SplA)<br>The SplA protein functions in trans as a negative regulator of the level of splB-lacZ expression in the developing forespore  .. 
+PF11133 Head fiber protein<br>This head fiber protein is also refereed to as Gp8.5. Gp8.5 is a structural protein in phage. It is a dispensable head protein.. 
+PF11134 Phage stabilisation protein<br>Members of this family are phage proteins that are probably involved with stabilising the condensed DNA within the capsid  .. 
+PF11135 Protein of unknown function (DUF2888)<br>Some members in this family of proteins with unknown function are annotated as immediate early protein ICP-18 however this cannot be confirmed.. 
+PF11136 Protein of unknown function (DUF2889)<br>Pfam-B_001473 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11137 Protein of unknown function (DUF2909)<br>Pfam-B_764 (release 23.0). This is a family of proteins conserved in Proteobacteria of unknown function.. 
+PF11138 Protein of unknown function (DUF2911)<br>Pfam-B_001491 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11139 Protein of unknown function (DUF2910)<br>Pfam-B_001487 (release 23.0). Some members in this bacterial family annotate the proteins as cytochrome C biogenesis proteins however this cannot be confirmed. Currently no function for this family is known.. 
+PF11140 Protein of unknown function (DUF2913)<br>Pfam-B_001499 (release 23.0). This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.. 
+PF11141 Protein of unknown function (DUF2914)<br>Pfam-B_001640 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11142 Protein of unknown function (DUF2917)<br>Pfam-B_001647 (release 23.0). This bacterial family of proteins appears to be restricted to Proteobacteria.. 
+PF11143 Protein of unknown function (DUF2919)<br>Pfam-B_001684 (release 23.0). This bacterial family of proteins has no known function. Some members are annotated as YfeZ however this cannot be confirmed.. 
+PF11144 Protein of unknown function (DUF2920)<br>Pfam-B_001778 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11145 Protein of unknown function (DUF2921)<br>Pfam-B_001920 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11146 Protein of unknown function (DUF2905)<br>Pfam-B_542 (release 23.0). This is a family of bacterial proteins conserved of unknown function.. 
+PF11148 Protein of unknown function (DUF2922)<br>Pfam-B_001999 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11149 Protein of unknown function (DUF2924)<br>Pfam-B_002010 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11150 Protein of unknown function (DUF2927)<br>Pfam-B_739 (release 23.0). This family is conserved in Proteobacteria.  Several members are described as being putative lipoproteins, but otherwise the function is not known.. 
+PF11151 Protein of unknown function (DUF2929)<br>Pfam-B_002101 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes.. 
+PF11152 Protein of unknown function (DUF2930)<br>Pfam-B_002135 (release 23.0). This family of proteins has no known function.. 
+PF11153 Protein of unknown function (DUF2931)<br>Pfam-B_002146 (release 23.0). Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently, there is no known function.. 
+PF11154 Protein of unknown function (DUF2934)<br>Pfam-B_002301 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11155 Domain of unknown function (DUF2935)<br>Pfam-B_002056 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.. 
+PF11157 Protein of unknown function (DUF2937)<br>Pfam-B_002314 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11158 Protein of unknown function (DUF2938)<br>Pfam-B_002317 (release 23.0). This bacterial family of proteins has no known function. Some members are thought to be membrane proteins however this cannot be confirmed.. 
+PF11159 Protein of unknown function (DUF2939)<br>Pfam-B_002321 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11160 Protein of unknown function (DUF2945)<br>Pfam-B_002448 (release 23.0). This family of proteins has no known function.. 
+PF11161 Protein of unknown function (DUF2946)<br>Pfam-B_002487 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11162 Protein of unknown function (DUF2946)<br>Pfam-B_002520 (release 23.0). This family of proteins has no known function.. 
+PF11163 Protein of unknown function (DUF2947)<br>Pfam-B_002524 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11164 Protein of unknown function (DUF2948)<br>Pfam-B_002527 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11165 Protein of unknown function (DUF2949)<br>Pfam-B_002571 (release 23.0). This family of proteins with unknown function appear to be restricted to Cyanobacteria.. 
+PF11166 Protein of unknown function (DUF2951)<br>Pfam-B_002585 (release 23.0). This family of proteins has no known function. It has a highly conserved sequence.. 
+PF11167 Protein of unknown function (DUF2953)<br>Pfam-B_002617 (release 23.0). This family of proteins has no known function.. 
+PF11168 Protein of unknown function (DUF2955)<br>Pfam-B_002614 (release 23.0). Some members in this family of proteins with unknown function annotate the proteins as membrane protein. However, this cannot be confirmed.. 
+PF11169 Protein of unknown function (DUF2956)<br>Pfam-B_002632 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11170 Protein of unknown function (DUF2957)<br>Pfam-B_002671 (release 23.0). Some members annotate the proteins to be putative lipoproteins however this cannot be confirmed. Currently no function is known for this family of proteins.. 
+PF11171 Protein of unknown function (DUF2958)<br>Pfam-B_002712 (release 23.0). Some members are annotated as lipoproteins however this cannot be confirmed. This family of proteins has no known function.. 
+PF11172 Protein of unknown function (DUF2959)<br>Pfam-B_002747 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11173 Protein of unknown function (DUF2960)<br>Pfam-B_002756 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11174 Protein of unknown function (DUF2970)<br>Pfam-B_713 (release 23.0). This short family is conserved in Proteobacteria. The function is not known.. 
+PF11175 Protein of unknown function (DUF2961)<br>Pfam-B_002770 (release 23.0). This family of proteins has no known function.. 
+PF11176 Protein of unknown function (DUF2962)<br>Pfam-B_002773 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11177 Protein of unknown function (DUF2964)<br>Pfam-B_002804 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11178 Protein of unknown function (DUF2963)<br>Pfam-B_002790 (release 23.0). This family of proteins with unknown function appears to be restricted to Mollicutes.. 
+PF11179 Protein of unknown function (DUF2967)<br>Pfam-B_002838 (release 23.0). This family of proteins with unknown function appears to be restricted to Drosophila.. 
+PF11180 Protein of unknown function (DUF2968)<br>Pfam-B_002850 (release 23.0). This family of proteins has no known function.. 
+PF11181 Heat induced stress protein YflT<br>YflT is a heat induced protein.. 
+PF11182 Alginate O-acetyl transferase AlgF <br>AlgF is essential for the addition of O-acetyl groups to alginate, an extracellular polysaccharide. The presence of O-acetyl groups plays an important role in the ability of the polymer to act as a virulence factor  .. 
+PF11183 Polymyxin resistance protein PmrD<br>PmrB forms a two-component system (TCS) with PmrA that allows Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin G  . The TCS is linked to another one via the polymyxin resistance protein PmrD. PmrD is the first protein identified to mediate the connectivity between the two TCSs.  It binds to the N terminal domain of the PmrA response regulator which prevents its dephosphorylation, thereby promoting the the transcription of genes involved in polymyxin resistance  .. 
+PF11184 Protein of unknown function (DUF2969)<br>Pfam-B_002861 (release 23.0). This family of proteins with unknown function appears to be restricted to Lactobacillales.. 
+PF11185 Protein of unknown function (DUF2971)<br>Pfam-B_002776 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11186 Protein of unknown function (DUF2972)<br>Pfam-B_002895 (release 23.0). Some members in this family of proteins with unknown function are annotated as sugar transferase proteins, however this cannot be confirmed.. 
+PF11187 Protein of unknown function (DUF2974)<br>Pfam-B_002933 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11188 Protein of unknown function (DUF2975)<br>Pfam-B_2875 & Pfam-B_3379 (release 23.0) & JH:B0MX27. This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.. 
+PF11189 Protein of unknown function (DUF2973)<br>Pfam-B_002929 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently they have no known function.. 
+PF11190 Protein of unknown function (DUF2976)<br>Pfam-B_002963 (release 23.0). This family of proteins has no known function. Some members are annotated as membrane proteins however this cannot be confirmed.. 
+PF11191 Protein of unknown function (DUF2782)<br>Gunasekaran P, Mistry J. Pfam-B_001700 (release 23.0). This is a bacterial family of proteins whose function is unknown.. 
+PF11192 Protein of unknown function (DUF2977)<br>Pfam-B_002980 (release 23.0). This family of proteins has no known function.. 
+PF11193 Protein of unknown function (DUF2812)<br>Gunasekaran P, Mistry J. Pfam-B_001697 (release 23.0). This is a bacterial family of uncharacterised proteins, however some members of this family are annotated as membrane proteins.. 
+PF11195 Protein of unknown function (DUF2829) <br>Gunasekaran P, Mistry J. Pfam-B_001848 (release 23.0). This is a uncharacterised family of proteins found in bacteria and bacteriphages.. 
+PF11196 Protein of unknown function (DUF2834)<br>Gunasekaran P, Mistry J. Pfam-B_001850 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11197 Protein of unknown function (DUF2835)<br>Gunasekaran P, Mistry J. Pfam-B_001851 (release 23.0). This is a bacterial family of uncharacterised proteins. One member of this family (Swiss:A4VM42) is annotated as the A subunit of Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV).. 
+PF11198 Protein of unknown function (DUF2857)<br>Gunasekaran P, Mistry J. Pfam-B_001886 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11199 Protein of unknown function (DUF2891)<br>Gunasekaran P, Mistry J. Pfam-B_001921 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11200 Protein of unknown function (DUF2981)<br>Pfam-B_003040 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11201 Protein of unknown function (DUF2982)<br>Pfam-B_003059 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11202 DUF2983;<br>Phosphoribosyl transferase (PRTase). This PRTase family has a C terminal RNA binding Pelota domain  . These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response  .. 
+PF11203 Protein of unknown function (DUF2984)<br>Pfam-B_003006 (release 23.0). Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed.. 
+PF11204 Protein of unknown function (DUF2985)<br>Pfam-B_003090 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11205 Protein of unknown function (DUF2987)<br>Pfam-B_003120 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11207 Protein of unknown function (DUF2989)<br>Pfam-B_003139 (release 23.0). Some members in this bacterial family of proteins are annotated as lipoproteins however this cannot be confirmed.. 
+PF11208 Protein of unknown function (DUF2992)<br>Pfam-B_003142 (release 23.0). This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologues of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesise nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches  .. 
+PF11209 Protein of unknown function (DUF2993)<br>Pfam-B_003144 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11210 Protein of unknown function (DUF2996)<br>Pfam-B_003176 (release 23.0). This family of proteins has no known function.. 
+PF11211 Protein of unknown function (DUF2997)<br>Pfam-B_003181 (release 23.0). This family of proteins has no known function.. 
+PF11212 Protein of unknown function (DUF2999)<br>Pfam-B_003194 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11213 Protein of unknown function (DUF3006)<br>Pfam-B_003197 (release 23.0). This family of proteins has no known function.. 
+PF11214 Mediator complex subunit 2<br>This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression  .. 
+PF11215 Protein of unknown function (DUF3010)<br>Pfam-B_003238 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11216 Protein of unknown function (DUF3012)<br>Pfam-B_003254 (release 23.0). This family of proteins with unknown function is restricted to Gammaproteobacteria.. 
+PF11217 Protein of unknown function (DUF3013)<br>Pfam-B_003257 (release 23.0). This bacterial family of proteins with unknown function appear to be restricted to Firmicutes.. 
+PF11218 Protein of unknown function (DUF3011)<br>Pfam-B_003246 (release 23.0). This bacterial family of proteins has no known function. Most members belong to Proteobacteria.. 
+PF11219 Protein of unknown function (DUF3014)<br>Pfam-B_003267 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11220 Protein of unknown function (DUF3015)<br>Pfam-B_003292 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11221 Subunit 21 of Mediator complex<br>Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator  .. 
+PF11222 Protein of unknown function (DUF3017)<br>Pfam-B_003304 (release 23.0). This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.. 
+PF11223 Protein of unknown function (DUF3020)<br>This family of fungal proteins is conserved towards the C-terminus of HMG domains. The function is not known.. 
+PF11224 Protein of unknown function (DUF3023)<br>Pfam-B_003319 (release 23.0). This bacterial family of proteins with unknown function appear to be restricted to Alphaproteobacteria.. 
+PF11225 Protein of unknown function (DUF3024)<br>Pfam-B_003325 (release 23.0). This family of proteins has no known function.. 
+PF11226 Protein of unknown function (DUF3022)<br>Pfam-B_003318 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11227 Protein of unknown function (DUF3025)<br>Pfam-B_003327 (release 23.0). Some members in this bacterial family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.. 
+PF11228 Protein of unknown function (DUF3027)<br>Pfam-B_003334 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11229 Protein of unknown function (DUF3028)<br>Pfam-B_003337 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11230 Protein of unknown function (DUF3029)<br>Pfam-B_003347 (release 23.0). Some members in this family of proteins are annotated as ykkI. Currently no function is known.. 
+PF11231 Protein of unknown function (DUF3034)<br>Pfam-B_003362 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11232 Med25_PTOV1;Med25_PTOV-SD2; <br>Mediator complex subunit 25 PTOV activation and synapsin 2. Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function  .  The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear  .. 
+PF11233 Protein of unknown function (DUF3035)<br>Pfam-B_003372 (release 23.0). This family of proteins with unknown function appear to be restricted to Alphaproteobacteria.. 
+PF11235 Mediator complex subunit 25 synapsin 1<br>The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear  .. 
+PF11236 Protein of unknown function (DUF3037)<br>Pfam-B_003382 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11237 Protein of unknown function (DUF3038)<br>Pfam-B_003387 (release 23.0). This family of proteins with unknown function appear to be restricted to Cyanobacteria.. 
+PF11238 Protein of unknown function (DUF3039)<br>Pfam-B_003408 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11239 Protein of unknown function (DUF3040)<br>Pfam-B_003409 (release 23.0). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.. 
+PF11240 Protein of unknown function (DUF3042)<br>Pfam-B_003420 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes.. 
+PF11241 Protein of unknown function (DUF3043)<br>Pfam-B_003428 (release 23.0). Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.. 
+PF11242 Protein of unknown function (DUF2774)<br>This is a viral family of proteins with unknown function.. 
+PF11243 Protein of unknown function (DUF3045)<br>Members in this family of proteins are annotated as gene protein 30.1. Currently no function is known.. 
+PF11244 Mediator complex subunit 25 C-terminal NR box-containing<br>The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR  .. 
+PF11245 Protein of unknown function (DUF2544)<br>This is a bacterial family of proteins with unknown function.. 
+PF11246 Base plate wedge protein 53<br>The baseplate of bacteriophage T4 controls host cell recognition, attachment, tail sheath contraction and viral DNA ejection. The structure of the baseplate suggests a mechanism of baseplate structural transition during the initial stages of T4 infection. The baseplate is assembled from six identical wedges that surround the central hub. Gp53, along with other T4 gene products, combine sequentially to assemble a wedge  .. 
+PF11247 Protein of unknown function (DUF2675) <br>Members in this family of proteins are annotated as Gene protein 5.5. Currently no function is known.. 
+PF11248 Protein of unknown function (DUF3046)<br>Pfam-B_3651 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11249 Protein of unknown function (DUF3047)<br>Pfam-B_3654 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11250 Protein of unknown function (DUF3049)<br>Pfam-B_3659 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11251 Protein of unknown function (DUF3050)<br>Pfam-B_3661 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11252 Protein of unknown function (DUF3051)<br>Pfam-B_3671 (release 23.0). This viral family of proteins has no known function.. 
+PF11253 Protein of unknown function (DUF3052)<br>Pfam-B_3674 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11254 Protein of unknown function (DUF3053)<br>Pfam-B_3678 (release 23.0). Some members in this family of proteins are annotated as the membrane protein YiaF. No function is currently known.. 
+PF11255 Protein of unknown function (DUF3054)<br>Pfam-B_3684 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11256 Protein of unknown function (DUF3055)<br>Pfam-B_3685 (release 23.0). This family of proteins with unknown function appear to be restricted to Firmicutes.. 
+PF11258 Protein of unknown function (DUF3048)<br>Pfam-B_3658 (release 23.0). Some members in this bacterial family of proteins are annotated as YerB. However currently no function is known.. 
+PF11259 Protein of unknown function (DUF3060)<br>Pfam-B_3702 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed.. 
+PF11260 Major ampullate spidroin 1 and 2<br>Pfam-B_001419 (release 23.0). Dragline silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2)  . MaSp1 contains five alpha-helices  . Only the C-terminus of the proteins are shown.. 
+PF11261 Interferon regulatory factor 2-binding protein zinc finger<br>Pfam-B_1430 (release 23.0). IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and  C-terminal RING finger domains  .. 
+PF11262 Transcription factor/nuclear export subunit protein 2<br>Pfam-B_002604 (release 23.0). THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability [1,2]. Tho2, along with four other subunits forms THO  . 
+PF11263 Borrelia burgdorferi attachment protein P66 <br>Pfam-B_003349 (release 23.0). P66 is an outer membrane protein in Borrelia burgdorferi, the agent of Lyme disease. P66 has a role in the attachment of Borrelia burgdorferi to human cell-surface receptors  .. 
+PF11264 Thylakoid formation protein<br>Pfam-B_003380 (release 23.0). THF1 is localised to the outer plastid membrane and the stroma. THF1 has a role in sugar signalling  . THF1 is also thought to have a role in chloroplast and leaf development  . THF1 has been shown to play a crucial role in vesicle-mediated thylakoid membrane biogenesis  .. 
+PF11265 Mediator complex subunit 25 von Willebrand factor type A<br>The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex  .. 
+PF11266 Protein of unknown function (DUF3066)<br>Pfam-B_3735 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11267 Protein of unknown function (DUF3067)<br>Pfam-B_3740 (release 23.0). This family of proteins has no known function.. 
+PF11268 Protein of unknown function (DUF3071)<br>Pfam-B_3805 (release 23.0). Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.. 
+PF11269 Protein of unknown function (DUF3069)<br>Pfam-B_3783 (release 23.0). This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.. 
+PF11270 Protein of unknown function (DUF3070)<br>Pfam-B_3804 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11271 Protein of unknown function (DUF3068)<br>Pfam-B_3769 (release 23.0). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.. 
+PF11272 Protein of unknown function (DUF3072)<br>Pfam-B_3823 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11273 Protein of unknown function (DUF3073)<br>Pfam-B_3852 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11274 Protein of unknown function (DUF3074)<br>Pfam-B_3858 (release 23.0). This eukaryotic family of proteins has no known function but appears to be part of the START superfamily.. 
+PF11275 Protein of unknown function (DUF3077)<br>Pfam-B_3820 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11276 Protein of unknown function (DUF3078)<br>Pfam-B_3846 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11277 Mediator complex subunit 24 N-terminal<br>This subunit of the Mediator complex appears to be conserved only from insects to humans. It is essential for correct retinal development in fish.  Subunit composition of the mediator contributes to the control of differentiation in the vertebrate CNS as there are divergent functions of the mediator subunits Crsp34/Med27, Trap100/Med24, and Crsp150/Med14  .. 
+PF11278 Protein of unknown function (DUF3079)<br>Pfam-B_3866 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11279 Protein of unknown function (DUF3080)<br>Pfam-B_3870 (release 23.0). Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently this family has no known function.. 
+PF11280 Protein of unknown function (DUF3081)<br>Pfam-B_3884 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11281 Protein of unknown function (DUF3083)<br>Pfam-B_3898 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11282 Protein of unknown function (DUF3082)<br>Pfam-B_3896 (release 23.0). This family of proteins has no known function.. 
+PF11283 Protein of unknown function (DUF3084)<br>Pfam-B_3912 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11284 Protein of unknown function (DUF3085)<br>Pfam-B_3922 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11285 Protein of unknown function (DUF3086)<br>Pfam-B_3929 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11286 Protein of unknown function (DUF3087)<br>Pfam-B_3938 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11287 Protein of unknown function (DUF3088)<br>Pfam-B_3952 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11288 Protein of unknown function (DUF3089)<br>Pfam-B_3953 (release 23.0). This family of proteins has no known function but appears to have an alpha/beta hydrolase domain and so is likely to be enzymatic.. 
+PF11289 Protein of unknown function (DUF3092)<br>Pfam-B_3988 (release 23.0). This viral family of proteins has no known function.. 
+PF11290 Protein of unknown function (DUF3090)<br>Pfam-B_3954 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11291 Protein of unknown function (DUF3091)<br>Pfam-B_3979 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11292 Protein of unknown function (DUF3093)<br>Pfam-B_4007 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria. Some members are annotated as alanine rich membrane proteins however this cannot be confirmed.. 
+PF11293 Protein of unknown function (DUF3094)<br>Pfam-B_4017 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11294 Protein of unknown function (DUF3095)<br>Pfam-B_4020 (release 23.0). Some members in this bacterial family of proteins are annotated as adenylyl cyclase however this cannot be confirmed. Currently no function is known.. 
+PF11295 Protein of unknown function (DUF3096)<br>Pfam-B_4028 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11296 Protein of unknown function (DUF3097)<br>Pfam-B_4031 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11297 Protein of unknown function (DUF3098)<br>Pfam-B_4061 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11298 Protein of unknown function (DUF3099)<br>Pfam-B_4064 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11299 Protein of unknown function (DUF3100)<br>Pfam-B_4068 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11300 Protein of unknown function (DUF3102)<br>Pfam-B_4016 (release 23.0). This family of proteins has no known function.. 
+PF11301 Protein of unknown function (DUF3103)<br>Pfam-B_4046 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11302 Protein of unknown function (DUF3104)<br>Pfam-B_4053 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11303 Protein of unknown function (DUF3105)<br>Pfam-B_4062 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11304 Protein of unknown function (DUF3106)<br>Pfam-B_4069 (release 23.0). Some members in this family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11305 Protein of unknown function (DUF3107)<br>Pfam-B_3881 (release 23.0). Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.. 
+PF11306 Protein of unknown function (DUF3108)<br>Pfam-B_3856 (release 23.0). This is a bacterial family of putative lipoproteins. The structure for Swiss:Q64U78, PDB:3fzx, the first structural template for this large family including several homologues in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Swiss:Q64U78 is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localisation for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit PDB:2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.. 
+PF11307 Protein of unknown function (DUF3109)<br>Pfam-B_4077 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11308 DUF3111; GHL;<br>Glycosyl hydrolases related to GH101 family, GHL1-GHL3. Pfam-B_4091 (release 23.0). This family of bacterial and lower eukaryote glycosyl hydrolases is related to CAZy family GH101, and is made up of sub-families GHL1-GHL3. In the example Swiss:C02A26, the substrate-binding Asp is residue 596, the nucleophilic Asp is residue 706, and the proton donor Glu is residue 747.. 
+PF11309 Protein of unknown function (DUF3112)<br>Pfam-B_4107 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11310 Protein of unknown function (DUF3113)<br>Pfam-B_4134 (release 23.0). This family of proteins has no known function. It has a highly conserved sequence.. 
+PF11311 Protein of unknown function (DUF3114)<br>Pfam-B_4178 (release 23.0). Some members in this family of proteins with unknown function are annotated as cytosolic proteins. This cannot be confirmed.. 
+PF11312 Protein of unknown function (DUF3115)<br>Pfam-B_4191 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11313 Protein of unknown function (DUF3116)<br>Pfam-B_4194 (release 23.0). This family of proteins with unknown function appears to be restricted to Bacillales.. 
+PF11314 Protein of unknown function (DUF3117)<br>Pfam-B_4211 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11315 Mediator complex subunit 30<br>Pfam-B_28118 (release 23.0). Med30 is a metazoan-specific subunit of Mediator, having no homologues in yeasts.. 
+PF11316 DUF3118;<br>Putative rhamnosyl transferase . Pfam-B_4218 (release 23.0). Most members of this family are uncharacterised, but one is a putative side-chain-rhamnosyl transferase  .. 
+PF11317 Protein of unknown function (DUF3119)<br>Pfam-B_4223 (release 23.0). This family of proteins has no known function.. 
+PF11318 Protein of unknown function (DUF3120)<br>Pfam-B_4230 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11319 Protein of unknown function (DUF3121)<br>Pfam-B_4233 (release 23.0). Some members in this family of proteins with unknown function are annotated as phospholipase proteins however this cannot be confirmed. Currently this family has no known function.. 
+PF11320 Protein of unknown function (DUF3122)<br>Pfam-B_4242 (release 23.0). This family of proteins with unknown function appear to be restricted to Cyanobacteria.. 
+PF11321 Protein of unknown function (DUF3123)<br>Pfam-B_4246 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11322 Protein of unknown function (DUF3124)<br>Pfam-B_4248 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11323 Protein of unknown function (DUF3125)<br>Pfam-B_4250 (release 23.0). This family of proteins with unknown function appears to be restricted to Staphylococcus.. 
+PF11324 Protein of unknown function (DUF3126)<br>Pfam-B_4268 (release 23.0). This family of proteins with unknown function appear to be restricted to Alphaproteobacteria.. 
+PF11325 Domain of unknown function (DUF3127)<br>Pfam-B_4273 (release 23.0). This bacterial family of proteins has no known function. However, it does show distant similarity to Pfam:PF00436, with proteins such as Swiss:D1W984 being similar to both families. This suggests that this family may have a DNA-binding function.. 
+PF11326 Protein of unknown function (DUF3128)<br>Pfam-B_4309 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11327 Protein of unknown function (DUF3129)<br>Pfam-B_4316 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11328 Protein of unknown function (DUF3130<br>Pfam-B_4322 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11329 Protein of unknown function (DUF3131)<br>Pfam-B_4335 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11330 Protein of unknown function (DUF3132)<br>Pfam-B_4348 (release 23.0). This viral family of proteins are 55kDa. No function is currently known.. 
+PF11331 Protein of unknown function (DUF3133)<br>Pfam-B_4400 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11332 Protein of unknown function (DUF3134)<br>Pfam-B_4408 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11333 Protein of unknown function (DUF3135)<br>Pfam-B_4409 (release 23.0). This family of proteins with unkown function appears to be restricted to Proteobacteria.. 
+PF11334 Protein of unknown function (DUF3136)<br>Pfam-B_4419 (release 23.0). This family of proteins with unknown function appear to be restricted to Cyanobacteria.. 
+PF11335 Protein of unknown function (DUF3137) <br>Pfam-B_4422 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11336 Protein of unknown function (DUF3138)<br>Pfam-B_4423 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11337 Protein of unknown function (DUF3139)<br>Pfam-B_4425 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes.. 
+PF11338 Protein of unknown function (DUF3140)<br>Pfam-B_4435 (release 23.0). Some members in this family of proteins are annotated as DNA binding proteins. No function is currently known.. 
+PF11339 Protein of unknown function (DUF3141)<br>Pfam-B_4443 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11340 Protein of unknown function (DUF3142)<br>Pfam-B_4454 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11341 Protein of unknown function (DUF3143)<br>Pfam-B_4460 (release 23.0). This family of proteins has no known function.. 
+PF11342 Protein of unknown function (DUF3144)<br>Pfam-B_4465 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11343 Protein of unknown function (DUF3145)<br>Pfam-B_4467 (release 23.0). This family of proteins with unknown function appear to be restricted to Actinobacteria.. 
+PF11344 Protein of unknown function (DUF3146)<br>Pfam-B_4468 (release 23.0). This family of proteins with unknown function appear to be restricted to Cyanobacteria.. 
+PF11345 Protein of unknown function (DUF3147)<br>Pfam-B_4475 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11346 Protein of unknown function (DUF3149)<br>Pfam-B_4495 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11347 Protein of unknown function (DUF3148)<br>Pfam-B_4488 (release 23.0). This family of proteins has no known function.. 
+PF11348 Protein of unknown function (DUF3150)<br>Pfam-B_4471 (release 23.0). This bacterial family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11349 Protein of unknown function (DUF3151)<br>Pfam-B_4506 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11350 Protein of unknown function (DUF3152)<br>Pfam-B_4512 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.. 
+PF11351 Protein of unknown function (DUF3154)<br>Pfam-B_4516 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11352 Protein of unknown function (DUF3155)<br>Pfam-B_4534 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11353 Protein of unknown function (DUF3153)<br>Pfam-B_4513 (release 23.0). This family of proteins with unknown function appear to be restricted to Cyanobacteria. Some members are annotated as membrane proteins however this cannot be confirmed.. 
+PF11354 Protein of unknown function (DUF3156)<br>Pfam-B_4555 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11355 Protein of unknown function (DUF3157)<br>Pfam-B_4561 (release 23.0). This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11356 Type IV pilus biogenesis<br>Pfam-B_3750 (release 23.0). Type IV pili are required for auto-agglutination, twitching motility, biofilm formation, adherence and DNA uptake during transformation  . PilP is an inner membrane protein, required for pilus expression and transformation  . PilP interacts with PilQ which suggests that the two proteins may have coordinated activity in functions such as pilus extrusion/retraction  .. 
+PF11357 Cell cycle regulatory protein<br>Pfam-B_3875 (release 23.0). Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events  . Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27  . Spy1 is also known as Ringo protein A.. 
+PF11358 Protein of unknown function (DUF3158)<br>Pfam-B_3964 (release 23.0). Some members in this family of proteins are annotated as integrase regulator R however this cannot be confirmed. This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11359 Glycoprotein UL132<br>Pfam-B_4015 (release 23.0). Glycoprotein UL132 is a low-abundance structural component of Human cytomegalovirus (HCMV)  . The function of this protein is not fully understood.. 
+PF11360 Protein of unknown function (DUF3110)<br>Pfam-B_4086 (release 23.0). This family of proteins has no known function.. 
+PF11361 Protein of unknown function (DUF3159)<br>Pfam-B_4163 (release 23.0). Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.. 
+PF11362 Protein of unknown function (DUF3161)<br>Pfam-B_4173 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11363 Protein of unknown function (DUF3164)<br>Pfam-B_4249 (release 23.0). This family of proteins has no known function.. 
+PF11364 Protein of unknown function (DUF3165)<br>Pfam-B_4331 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.. 
+PF11365 Protein of unknown function (DUF3166)<br>Pfam-B_4333 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11367 Protein of unknown function (DUF3168)<br>Pfam-B_4337 (release 23.0). This family of proteins has no known function but is likely to be a component of bacteriophage.. 
+PF11368 Protein of unknown function (DUF3169)<br>Pfam-B_4342 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.. 
+PF11369 Protein of unknown function (DUF3160)<br>Pfam-B_4384 (release 23.0). This family of proteins has no known function.. 
+PF11371 Protein of unknown function (DUF3172)<br>Pfam-B_4527 (release 23.0). This family of proteins has no known function.. 
+PF11372 Domain of unknown function (DUF3173)<br>Pfam-B_4543 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes. These proteins appear to be distantly related to HHH domains and are therefore likely to be DNA-binding.. 
+PF11373 Protein of unknown function (DUF3175)<br>Pfam-B_4566 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11374 Protein of unknown function (DUF3176)<br>Pfam-B_4567 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11375 Protein of unknown function (DUF3177)<br>Pfam-B_4580 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.. 
+PF11376 Protein of unknown function (DUF3179)<br>Pfam-B_4591 (release 23.0). This family of proteins has no known function.. 
+PF11377 Protein of unknown function (DUF3180)<br>Pfam-B_4592 (release 23.0). Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.. 
+PF11378 Protein of unknown function (DUF3181)<br>Pfam-B_4595 (release 23.0). This family of proteins has no known function.. 
+PF11379 Protein of unknown function (DUF3182)<br>Pfam-B_4440 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11380 Protein of unknown function (DUF3184)<br>Pfam-B_4192 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11381 Protein of unknown function (DUF3185)<br>Pfam-B_4606 (release 23.0). Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.. 
+PF11382 Protein of unknown function (DUF3186)<br>Pfam-B_4607 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11383 Protein of unknown function (DUF3187)<br>Pfam-B_4660 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria. These proteins are likely to be outer membrane proteins.. 
+PF11384 Protein of unknown function (DUF3188)<br>Pfam-B_4573 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11385 Protein of unknown function (DUF3189)<br>Pfam-B_4499 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes. 
+PF11386 Vitelline envelope receptor for lysin<br>Pfam-B_1349 (release 23.0). VERL, the egg vitelline envelope (VE) receptor for lysin, is a giant unbranched glycoprotein comprising 30% of the vitelline envelope. Lysin binds to VERL and creates a hole as VERL molecules lose cohesion and splay apart. These proteins are important in the mediation of fertilisation  . 
+PF11387 Protein of unknown function (DUF2795)<br>Pfam-B_1395 (release 23.0). This family of proteins has no known function.. 
+PF11388 Phagosome trafficking protein DotA<br>Pfam-B_001493 (release 23.0). DotA is essential for intracellular growth in Legionella  . DotA is thought to play an important role in regulating initial phagosome trafficking decisions either upon or immediately after macrophage uptake  .. 
+PF11389 Leptospira porin protein OmpL1<br>Pfam-B_001515 (release 23.0). OmpL1 is a member of the outer membrane (OM) proteins in the mammalian pathogen Leptospira. Specifically, it is a porin  .. 
+PF11390 NADH-dependant formate dehydrogenase delta subunit FdsD<br>Pfam-B_1352 (release 23.0). FdsD is the delta subunit of the enzyme formate dehydrogenase. This subunit may play a role in maintaining the quaternary structure by means of electrostatic interactions with the other subunits  . The delta subunit is not involved in the active centre of the enzyme  .. 
+PF11391 Protein of unknown function (DUF2798)<br>Pfam-B_1194 (release 23.0). This family of proteins has no known function.. 
+PF11392 Protein of unknown function (DUF2877)<br>Pfam-B_002434 (release 23.0). This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.. 
+PF11393 Macrophage killing protein with similarity to conjugation protein<br>Pfam-B_002787 (release 23.0). IcmL contains two amphipathic beta-sheet regions, required for the pore-forming ability which may be related to the transfer of this protein into a host cell membrane  . The icmL gene shows significant similarity to plasmid genes involved in conjugation however IcmL is thought to be required for macrophage killing. It is unknown whether conjugation plays a role in macrophage killing  .. 
+PF11394 Protein of unknown function (DUF2875)<br>Pfam-B_002814 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11395 Protein of unknown function (DUF2873)<br>Pfam-B_002845 (release 23.0). This viral family of proteins has no known function.. 
+PF11396 Protein of unknown function (DUF2874)<br>Pfam-B_002962 (release 23.0). This bacterial family of proteins is probably periplasmic and of unknown function.\.     There may be between one and six copies of this domain per sequence.. 
+PF11397 Glycosyltransferase (GlcNAc)<br>Pfam-B_002901 (release 23.0). GlcNAc is an enzyme that carries out the first glycosylation step of hydroxylated Skp1, a ubiquitous eukaryotic protein, in the cytoplasm  .. 
+PF11398 Protein of unknown function (DUF2813)<br>Pfam-B_002207 (release 23.0). This entry contains YjbD from Escherichia coli (Swiss:P75828), which is annotated as a nucleotide triphosphate hydrolase.. 
+PF11399 Protein of unknown function (DUF3192)<br>Pfam-B_002991 (release 23.0). Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed.. 
+PF11401 Tetrabrachion<br>Tetrabrachion forms a parallel right-handed coiled coil structure with hydrophobic interactions and salt bridges forming a thermostable tetrameric structure. It contains large hydrophobic cavities. No function is known for this family of proteins  .. 
+PF11402 Antifungal protein<br>Antifungal protein consists of five antiparallel beta strands which are highly twisted creating a beta barrel stabilised by four internal disulphide bridges  . A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site  .. 
+PF11403 Yeast metallothionein<br>Metallothioneins are characterised by an abundance of cysteine residues and a lack of generic secondary structure motifs. This protein functions in primary metal storage, transport and detoxification  . For the first 40 residues in the protein the polypeptide wraps around the metal by forming two large parallel loops separated by a deep cleft containing the metal cluster  .. 
+PF11404 Potassium voltage-gated channel<br>Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons  . Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation  .. 
+PF11405 Bromelain_inhib;<br>Bromelain inhibitor VI. Bromelain inhibitor VI is a double-chain inhibitor consisting of a 11-residue and a 41-residue chain. This protein is the 41-residue heavy chain which is joined to the 11-residue chain by disulphide bonds. The inhibitor acts to inhibit the cysteine proteinase bromelain  .. 
+PF11406 Antimicrobial peptide tachystatin A<br>Tachystatin A contains a cysteine-stabilised triple-stranded beta-sheet and shows features common to membrane-interactive peptides. Tachystatin A is thought to have an antimicrobial activity similar to defensins.Tachystatin A is also a chitin-binding peptide  .. 
+PF11407 Type II restriction enzyme MunI<br>Type II restriction enzyme MunI recognises the palindromic sequence C/AATTG. It makes contact with the DNA via the major groove  .. 
+PF11408 Sgs1 RecQ helicase<br>RecQ helicases unwind DNA in an ATP-dependent manner. Sgs1 has a HRDC (helicase and RNaseD C-terminal) domain which modulates the helicase function via auxiliary contacts to DNA  . . 
+PF11409 Smad anchor for receptor activation (SARA)<br>Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus  . SARA recruits Smad2 to the TGF-beta receptors for phosphorylation  .. 
+PF11410 Antifungal peptide<br>This peptide has six cysteines involved in three disulphide bonds. It contains a global fold which involves a cysteine-knotted three-stranded antiparallel beta-sheet along with a flexible loop and four beta-reverse turns. It also has an amphiphilic character which is the main structural basis of its biological function  .. 
+PF11411 DNA ligase IV<br>DNA ligase IV along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface  .. 
+PF11412 Disulphide bond corrector protein DsbC<br>DsbC rearranges incorrect disulphide bonds during oxidative protein folding. It is activated by the N-terminal domain of DsbD, a transmembrane electron transporter. DsbD binds to a DsbC dimer and selectively activates it using electrons from the cytoplasm  .. 
+PF11413 Hypoxia-inducible factor-1<br>HIF-1 is a transcriptional complex and controls cellular systemic homeostatic responses to oxygen availability  . In the presence of oxygen HIF-1 alpha is targeted for proteasomal degradation by pHVL, a ubiquitination complex  .. 
+PF11414 Adenomatous polyposis coli tumour suppressor protein<br>The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils  .. 
+PF11415 Termicin;<br>Antifungal peptide termicin. Termicin is a cysteine-rich antifungal peptide which exhibits antibacterial activity. A cysteine stabilised alpha beta motif is formed due to an alpha-helical segment and a two-stranded antiparallel beta-sheet  .. 
+PF11416 Integral membrane protein Sed5p<br>Sed5p interacts with Sly1p , a positive regulator of intracellular membrane fusion, allowing SM proteins to stay associated with the assembling fusion machinery. This allows for participation in late fusion steps  .. 
+PF11417 Loader and inhibitor of phage G40P<br>G39P inhibits the initiation of DNA replication by blocking G40P replicative helicase. G39P has a bipartite stricture consisting of a folded N-terminal domain and an unfolded C-terminal domain. The C terminal is essential for helicase interaction  .. 
+PF11418 Phi29 scaffolding protein<br>This protein is also referred to as gp7. The protein contains a DNA-binding function and may halve a role in mediating the structural transition from prohead to mature virus and also scaffold release  .Gp7 is arranged within the capsid as a series of concentric shells  .. 
+PF11419 Protein of unknown function (DUF3194)<br>This family of proteins has no known function however the structure has been determined. The protein consists of two alpha-helices packed on the same side of a central beta-hairpin  .. 
+PF11420 Bacteriocin subtilosin A<br>Subtilosin A is a bacteriocin from Bacillus subtilis.The protein has a cyclized peptide backbone and forms three cross-liks between the sulphurs of Cys13, Cys7 and Cys4 and the alpha-positions of Phe22,Thr28 and Phe31  .. 
+PF11421 ATP synthase F1 beta subunit<br>The NMR solution structure of the protein in SDS micelles was found to contain two helices, an N-terminal amphipathic alpha-helix and a C-terminal alpha-helix separated by a large unstructured internal domain. The N-terminal alpha-helix is the Tom20 receptor binding site whereas the C-terminal alpha-helix is located upstream of the mitochondrial processing peptidase cleavage site  .. 
+PF11422 Initiator binding protein 39 kDa<br>IBP39 recognises the initiator which is solely responsible for transcription start site selection. IBP39 contains an N-terminal Inr binding domain connected to a C-terminal domain. The C domain structure indicates that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. Binding of IBP39 to Inr recruits RNAP II and initiates transcription  .. 
+PF11423 Regulatory protein Mnt<br>Mnt is a repressor which is involved in the genetic switch between lysogenic and lytic growth in bacteriophage P22. The C-terminal domain of the protein consists of a dimer of two antiparallel coiled coils with a right handed twist, which is both stronger and has closer inter-helical separation compared with those found in left-handed coiled coils  .. 
+PF11424 Protein of unknown function (DUF3195)<br>This archaeal family of proteins has no known function.. 
+PF11426 Tn7_TnsC;<br>Tn7 transposition regulator TnsC. TnsC is a molecular switch that regulates transposition and interacts with TnsA which is a component of the transposase. The two proteins interact via the residues 504-555 on TnsC. The TnsA/TnsC interaction is very important in Tn7 transposition  .. 
+PF11427 Tc3_transposase;<br>Tc3 is transposase with a specific DNA-binding domain which contains three alpha-helices, two of which form a helix-turn-helix motif which makes four base-specific contacts with the major groove. The N-terminus makes contacts with the minor groove. There is a base specific recognition between Tc3 and the transposon DNA. The DNA binding domain forms a dimer in which each monomer binds a separate transposon end. This implicates that the dimer has a role in synapsis and is necessary for the simultaneous cleavage of both transposon termini  .. 
+PF11428 Protein of unknown function (DUF3196)<br>This proteins is the product of the gene MPN330 and is thought to involved in a cellular function that has yet to be characterised. The proteins has 11 helices and a novel fold  . No function is currently known for this protein.. 
+PF11429 Colicin D<br>Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA cleavage. It targets the four isoaccepting tRNAs for Arg and cleaves the phosphodiester bond between positions 38 and 39 at the 3' junction of the anticodon stem and the loop  .. 
+PF11430 Programmed cell death activator EGL-1<br>Initiation of programmed cell death in C.elegans occurs by the binding of EGL-1 to CED-9 which disrupts a complex involving CED-4/CED-9 and allows CED-4 to activate CED-3, a caspase. It is the C terminal domain of EGL-1 which is involved in the formation of the complex with CED-9. The formation of the complex induces structural rearrangements in CED-9 and EGL-1 adopts an extended alpha-helical conformation  .. 
+PF11431 Membrane transport protein MerF<br>The mercury transport membrane protein, MerF has a core helix-loop-helix domain. It has two vicinal pairs of cysteine residues which are involved in the transport of Hg(II) across the membrane and are exposed to the cytoplasm  .. 
+PF11432 Protein of unknown function (DUF3197)<br>This bacterial family of proteins has no known function.. 
+PF11433 Protein of unknown function (DUF3198)<br>Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently, this archaeal family has no known function.. 
+PF11434 Chemotaxis-inhibiting protein CHIPS<br>The chemotaxis inhibitory protein, CHIPS, is an excreted virulence factor which acts by binding to C5a and formylated peptide receptor (FPR), blocking phagocyte responses. A fragment of CHIPS, which contains residues 31-121 comprises of an alpha helix packed onto a four stranded anti-parallel beta-sheet. Most of the conserved residues of CHIPS are present in the alpha-helix  .. 
+PF11435 RNA binding protein She2p<br>She2p is a RNA binding protein which binds to RNA via a helical hairpin. The protein is required for the actin dependent transport of ASH1 mRNA in yeast, a form of mRNP translocation. ASH1 mRNP requires recognition of zip code elements by the RNA binding protein She2p. She2p contains a globular domain consisting of a bundle of five alpha-helices  .. 
+PF11436 Protein of unknown function (DUF3199)<br>Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.. 
+PF11437 Vanadium-binding protein 2<br>The Vanadium binding protein, Vanabin2, contains four alpha-helices connected by nine disulphide bonds. Vanadium accumulates in Ascidians however the biological reason remains unclear  .. 
+PF11438 36-mer N-terminal peptide of the N protein (N36)<br>The arginine-rich motif of the N protein is involved in transcriptional antitermination of phage lambda. N36 forms a complex with boxB RNA by binding tightly to the major groove of the boxB hairpin via hydrophobic and electrostatic interactions forming a bent alpha helix  .. 
+PF11439 DUF3200;<br>Type III secretion system filament chaperone CesA. This family represents a chaperone protein for the type III secretion system - TTSS - translocon protein EspA, to prevent the latter's self-polymerisation. The TTSS is a highly specialised bacterial protein secretory pathway, similar in many ways to the flagellar system, that is essential for the pathogenesis of many Gram-negative bacteria. The twenty or so proteins making up the TTSS apparatus, referred to as the needle complex, allow the injection of virulence proteins (known as effectors) directly into the cytoplasm of the eukaryotic host cells they infect; however, the injection process itself is mediated by a subset of extracellular proteins that are secreted by the needle complex to the bacterial surface and assembled into the type III translocon - EspA. EspB and EspD. EspA polymerises into an extracellular filament, and, as with other fibrous proteins, is apt to undergo massive polymerisation when overexpressed. CesA is the secretion chaperone protein that binds to EspA. CesA is dimeric and helical, and it traps EspA in a monomeric state and inhibits its polymerisation.. 
+PF11440 DNA alpha-glucosyltransferase<br>The T4 bacteriophage of E.coli protects its DNA via two glycosyltransferases which glucosylate 5-hydroxymethyl cytosines (5-HMC) using UDP-glucose. These two proteins are the retaining alpha-glucosyltransferase (AGT) and the inverting beta-glucosyltransferase (BGT). The proteins in this family are AGT. AGT adopts the GT-B fold and binds both the sugar donor and acceptor to the C-terminal domain. There is evidence for a role of AGT in the base-flipping mechanism and for its specific recognition of the acceptor base  .. 
+PF11441 Pilot protein MxiM<br>MxiM, a Shigella pilot protein, is essential for the assembly and membrane association of the Shigella secretin MxiD. MxiM contains an orthologous secretin component and has a specific binding domain for the acyl chains of bacterial lipids  . The C terminal domain of MxiD hinders lipid binding to MxiM  .. 
+PF11442 Protein of unknown function (DUF2826)<br>Gunasekaran P, Mistry J. Pfam-B_001753 (release 23.0). This is a family of uncharacterised proteins that is highly conserved in Trypanosoma cruzi.. 
+PF11443 Domain of unknown function (DUF2828)<br>Gunasekaran P, Mistry J. Pfam-B_001814 (release 23.0). This is a uncharacterised domain found in eukaryotes and viruses.. 
+PF11444 Protein of unknown function (DUF2895)<br>Gunasekaran P, Mistry J. Pfam-B_002001 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11445 Protein of unknown function (DUF2894)<br>Gunasekaran P, Mistry J. Pfam-B_001968 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11446 Protein of unknown function (DUF2897)<br>Gunasekaran P, Mistry J. Pfam-B_002015 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11447 Protein of unknown function (DUF3201)<br>This archaeal family of proteins has no known function.. 
+PF11448 Protein of unknown function (DUF3005)<br>Gunasekaran P, Mistry J. Pfam-B_3492 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11449 Protein of unknown function (DUF2899)<br>Gunasekaran P, Mistry J. Pfam-B_002023 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11450 Protein of unknwon function (DUF3008)<br>Gunasekaran P, Mistry J. Pfam-B_3521 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11452 Protein of unknown function (DUF3000)<br>Gunasekaran P, Mistry J. Pfam-B_3481 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11453 Protein of unknown function (DUF2950)<br>Gunasekaran P, Mistry J. Pfam-B_002484 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11454 Protein of unknown function (DUF3016)<br>Gunasekaran P, Mistry J. Pfam-B_3517 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11455 Protein  of unknown function (DUF3018)<br>Gunasekaran P, Mistry J. Pfam-B_3532 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11456 Protein of unknown function (DUF3019)<br>Gunasekaran P, Mistry J. Pfam-B_3539 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11457 Protein of unknown function (DUF3021)<br>Gunasekaran P, Mistry J. Pfam-B_3526 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11458 Membrane-integrating protein Mistic<br>Mistic is an integral membrane protein that folds autonomously into the membrane  .The protein forms a helical bundle with a polar lipid-facing surface. Mistic can be used for high-level production of other membrane proteins in their native conformations  .. 
+PF11459 Protein of unknwon function (DUF2893)<br>Gunasekaran P, Mistry J. Pfam-B_001947 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11460 Protein of unknown function (DUF3007)<br>Gunasekaran P, Mistry J. Pfam-B_3514 (release 23.0). This is a family of uncharacterised proteins found in bacteria and eukaryotes.. 
+PF11461 Rab interacting lysosomal protein<br>RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes  .. 
+PF11462 Protein of unknown function (DUF3203)<br>This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.. 
+PF11463 R.HinP1I restriction endonuclease<br>Hinp1I is a type II restriction endonuclease, recognising and cleaving a palindromic tetranucleotide sequence (G/CGC) resulting in 2 nt 5' overhanging ends  . HINP1I has a conserved catalytic core domain containing an active site motif SDC18QXK and a DNA-binding domain  .. 
+PF11464 Rabenosyn Rab binding domain<br>Rabenosyn-5 (Rbsn) is a multivalent effector with interacts with the Rab family.Rsbn contains distinct Rab4 and Rab5 binding sites within residues 264-500 and 627-784 respectively  . Rab proteins are GTPases involved in the regulation of all stages of membrane trafficking  .. 
+PF11465 Natural killer cell receptor 2B4<br>2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells  . The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function  .. 
+PF11466 Prion-like protein Doppel<br>Dpl is a homologue related to the prion protein (PrP). Dpl is toxic to neurons and is expressed in the brains of mice that do not express PrP. In DHPC and SDS micelles, Dpl shoes about 40% alpha-helical structure however in aqueous solution it consists of a random coil. The alpha helical segment can adopt a transmembrane localisation also in a membrane  . The unprocessed Dpl protein is thought to posses a possible channel formation mechanism which may be related to toxicity through direct interaction with cell membranes and damage to the cell membrane  .. 
+PF11467 Lens epithelium-derived growth factor (LEDGF) <br>LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure  .. 
+PF11468 Aromatic prenyltransferase Orf2<br>In vivo Orf2 attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during naphterpin biosynthesis  . In vitro, Orf2 catalyses carbon-carbon based and carbon-oxygen based prenylation of hydroxyl-containing aromatic acceptors of synthetic, microbial and plant origin  .. 
+PF11469 DUF3204;<br>This is a family of archaeal ribonuclease_III proteins.. 
+PF11470 TUG;<br>GLUT4 regulating protein TUG. TUG is a GLUT4 regulating protein and functions to retain membrane vesicles containing GLUT4 intracellularly. TUG releases the GLUT4 containing vesicles to the cellular exocytic machinery in response to insulin stimulation which allows translocation to the plasma membrane  . TUG has an N-terminal ubiquitin-like domain (UBL1) which in similar proteins appears to participate in protein-protein interactions  . The region does have a area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein-protein interaction site  .. 
+PF11471 DUF3205;<br>Maltoporin periplasmic N-terminal extension. Pollington J, Coggill P. This domain would appear to be the periplasmic, N-terminal extension of the outer membrane maltoporins, Pfam:PF02264, LamB.. 
+PF11472 Protein of unknown function (DUF3206)<br>This bacterial family of proteins has no known function.. 
+PF11473 RNA binding protein B2<br>B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex  .. 
+PF11474 Telomerase reverse transcriptase TEN domain<br>This is the N terminal domain of the protein telomerase reverse transcriptase called TEN. The TEN domain is able to bind both RNA and telomeric DNA and contributes towards telomerase catalysis. The TEN domain has a structure that consists of a core beta sheet surrounded by seven alpha helices and a short beta hairpin  .. 
+PF11475 Virion protein N terminal domain <br>This is the N terminal domain of a family of virion proteins which contains a zinc finger domain. Currently no function is known.. 
+PF11476 Toxoplasma gondii micronemal protein 1 TgMIC1<br>TgMIC1 is released as part of a complex by Toxoplasma gondii prior to invasion. The complex which consists of TgMIC4-MIC1-MIC6 participates in host cell attachment and penetration and is critical in invasion. This is the C terminal domain of TgMIC1 which has a Galectin-like fold which interacts with and stabilises TgMIC6 providing a mechanism for an exit from the early secretory compartments and trafficking of the complex to micronemes  .. 
+PF11477 Sialyltransferase PMO188<br>PMO188 is a sialyltransferase from P.multocida. It transfers sialic acid from cytidine 5'-monophosphonuraminic acid to an acceptor sugar  . It has important catalytic residues such as Asp141, His311, Glu338, Ser355 and Ser356  .. 
+PF11478 Antimicrobial chitin binding protein tachystatin B<br>Tachystatin B is an antimicrobial chitin binding peptide and consists of two isotopes B1 and B2.Both structures contain a short antiparallel beta sheet with an inhibitory cysteine knot motif. Tyr(14) and Arg(17) are thought to be the essential residues for chitin binding  .. 
+PF11479 RNA silencing suppressor P21<br>P21 is produced by Beet yellows virus to suppress the antiviral silencing response mounted by the host. P21 acts by binding directly to siRNA which is a mediator in the process. P21 has an octameric ring structure with a large central cavity  . . 
+PF11480 Colicin-E5 Imm protein<br>Imms bind specifically to cognate colicins in order to protect their host cells  . Imm-E5 is a specific inhibitor protein of colicin E5. It binds to E5 C-terminal ribonuclease domain (CRD) to prevent cell death. The binding mode of E5-CRD and Imm-E5 mimics that of mRNA and tRNA suggesting an evolutionary pathway from the RNA-RNA interaction through the RNA-protein interaction of tRNA/E5-CRD  .. 
+PF11482 Protein of unknown function (DUF3208)<br>This bacterial family of proteins has no known function.. 
+PF11483 Protein of unknown function (DUF3209)<br>This family of proteins has no known function.. 
+PF11485 Protein of unknown function (DUF3211)<br>This archaeal family of proteins has no known function.. 
+PF11486 Protein of unknown function (DUF3212)<br>Members in this family of proteins are annotated as YfmB however currently no function for this protein is known.. 
+PF11487 Type II restriction enzyme SfiI<br>SfiI is a restriction enzyme that can cleave two DNA sites simultaneously to leave 3-base 3' overhangs. It acts as a homo-tetramer and recognises a specific eight base-paid palindromic DNA sequence. After binding two copies of its recognition sequence, SfiI becomes activated leading to cleavage of all four DNA strands. The structure of SfiI consists of a central twisted beta-sheet surrounded by alpha-helices.. 
+PF11488 Transcriptional regulatory protein LGE1<br>This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B.  This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters  . In S. pombe the equivalent protein to Lge1 appears to be Shf1.. 
+PF11489 Protein of unknown function (DUF3210)<br>This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is Swiss:O94497 and the Saccharomyces cerevisiae member is Swiss:P40563.. 
+PF11490 DNA_pol3_alph_N;<br>DNA polymerase III polC-type N-terminus II. Pfam-B_853 (release 23.0). This is the second N-terminal domain, NII domain, of the DNA polymerase III polC subunit A that is found only in Firmicutes. DNA polymerase polC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria  .  Purine asymmetry is a characteristic of organisms with a heterodimeric DNA polymerase III alpha-subunit constituted by polC which probably plays a direct role in the maintenance of strand-biased gene distribution; since, among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased  . It has been predicted that the N-terminus of polC folds into two globular domains, NI and NII. A predicted hydrophobic surface patch suggests this domain may be involved in protein binding  . This domain is associated with DNA_pol3_alpha Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF14480.. 
+PF11491 Protein of unknown function (DUF3213)   <br>The backbone structure of this family of proteins has been determined however the function remains unknown. The protein has an alpha and beta structure with a ferredoxin-like fold  .. 
+PF11492 Cricket paralysis virus, VP4<br>This is a family of minor capsid proteins, known as VP4, from the dicistroviridae. The dicistroviridae is a group of small, RNA-containing viruses that are closely structurally related to the picornaviridae. VP4 is a short, extended polypeptide chain found within the viral capsid, at the interface between the external protein shell and packaged RNA genome .. 
+PF11493 Thylakoid soluble phosphoprotein TSP9<br>The plant-specific protein, TSP9 is phosphorylated and released in response to changing light conditions from the photosynthetic membrane. The protein resembles the characteristics of transcription/translation regulatory factors. The structure of the protein is predicted to consist of a random coil  .. 
+PF11494 Ta0938<br>Ta0938 is a protein of unknown function however the structure has been determined. The protein has a novel fold and a putative Zn-binding motif. The structure has two different parts, one region contains a beta sheet flanked by two alpha helices and the other contains a bundle of loops which contain all cysteines in the protein  .. 
+PF11495 Archaeal transcriptional regulator TrmB<br>TrmB is an alpha-glucoside sensing transcriptional regulator. The protein is the transcriptional repressor for gene cluster encoding trehalose/maltose ABC transporter in T.litoralis and P.furiosus  . TrmB has lost its DNA binding domain but retained its sugar recognition site. A nonreducing glucosyl residue is shared by all substrates bound to TrmB which suggests that its a common recognition motif  .. 
+PF11496 Class II histone deacetylase complex subunits 2 and 3<br>This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus  .. 
+PF11497 NADH-quinone oxidoreductase chain 15<br>This protein, Nqo15, is a part of respiratory complex 1 which is a complex that plays a central role in cellular energy production in both bacteria and mitochondria. Nqo15 has a similar fold to Frataxin, the mitochondrial iron chaperone. This protein may have a role in iron-sulphur cluster regeneration in the complex. This domain represents more than half the molecular mass of the entire complex  .. 
+PF11498 Transcriptional activator LAG-3<br>The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12  . Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1  .. 
+PF11500 Spindle pole body formation-associated protein<br>This is the central coiled-coil region of cut12 also found in other fungi, barring S. cerevisiae. The full protein has two predicted coiled-coil regions, and one consensus phosphorylation site for p34cdc2 and two for MAP kinase. During fission yeast mitosis, the duplicated spindle pole bodies (SPBs) nucleate microtubule arrays that interdigitate to form the mitotic spindle. Cut12 is localised to the SPB throughout the cell cycle, predominantly around the inner face of the interphase SPB, adjacent to the nucleus  . Cut12 associates with Fin1 and is important in this context for the activity of Plo1  .. 
+PF11501 Non structural protein Nsp1<br>Nsp1 is the N-terminal cleavage product from the viral replicase that mediates RNA replication and processing  . The specific function of the protein is unknown however the structure has been determined. The protein has a novel alpha/beta fold formed by a 6 stranded beta barrel with an alpha helix covering one end of the barrel and another helix alongside the barrel  . Nsp1 could be involved in the degradation of mRNA.. 
+PF11502 B-cell lymphoma 9 protein<br>The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes  .. 
+PF11503 Protein of unknown function (DUF3215)<br>This family of proteins with unknown function appears to be restricted to Saccharomycetaceae.. 
+PF11504 Colicin Ia<br>Colicins are toxic molecules secreted to kill other bacteria in times of stress. Colicin Ia kills susceptible E.coli cells by binding to the colicin I receptor leading to the formation of a voltage-dependant ion channel. The protein can be divided into three domains, a translocation domain, a receptor binding domain and a channel forming domain  .. 
+PF11505 Protein of unknown function (DUF3216)<br>This family of archaeal proteins with unknown function appears to be restricted ton Thermococcaceae.. 
+PF11506 Protein of unknown function (DUF3217)<br>This family of proteins with unknown function appears to be restricted to Mycoplasma. Some members in this family of proteins are annotated as MG376 however this cannot be confirmed.. 
+PF11507 Ebola virus-specific transcription factor VP30<br>VP30 is a nucleocapsid-associated Ebola virus-specific transcription factor  . It acts by stabilising nascent mRNA in Ebola virus replication. The C terminal domain of VP30 folds into a dimeric helical assembly. VP30 assembles into hexamers in solution by an N-terminal oligomerisation domain which activates the transcription function of the protein. The oligomerisation is mediated by hydrophobic amino acids at 94-112  .. 
+PF11508 Protein of unknown function (DUF3218)<br>This family of proteins with unknown function appears to be restricted to Pseudomonas.. 
+PF11510 Fanconi Anaemia group E protein FANCE<br>Fanconi Anaemia (FA) is a cancer predisposition disorder. In response to DNA damage, the FA core complex monoubiquitinates the downatream FANCD2 protein. The protein FANCE has an important role in DNA repair as it is the FANCD2-binding protein in the FA core complex so it represents the link between the FA core complex and FANCD2  . The sequence shown is the C terminal domain of the protein which consists predominantly of helices and does not contain any beta-strand. The fold of the polypeptide is a continuous right-handed solenoidal pattern from the N terminal to the C terminal end  .. 
+PF11511 Intrinsic membrane protein PufX<br>PufX organises RC-LH1, the photosynthesis reaction centre-light harvesting complex 1 core complex of Rhodobacter sphaeroides  . It also facilitates the exchange of quinol for quinone between the reaction centre and cytochrome bc(1) complexes. In organic solvent, PufX contains two hydrophobic helices which are flanked by unstructured regions and connected by a helical bend  .. 
+PF11512 Agrobacterium tumefaciens protein Atu4866<br>Atu4866 is a protein with unknown function from Agrobacterium tumefaciens however the structure has been determined. Atu4866 adopts a streptavidin-like fold and has a beta-barrel/sandwich which is formed by eight antiparallel beta-strands  . Atu4866 has a potential ligand-binding site where is has a stretch of conserved residues on the surface  .. 
+PF11513 Thermoplasma acidophilum protein TA0956<br>TA0956 is a protein from Thermoplasma acidophilum which currently has no known function however the structure has been determined. The protein has a two-layered alpha/beta-sandwich topology and is a putative Elongation factor 1-alpha binding motif  .. 
+PF11514 Protein of unknown function (DUF3219)<br>This family of proteins with unknown function appears to be restricted to Bacillaceae. Some members in this family of proteins are annotated as YkvR however this cannot be confirmed.. 
+PF11515 Mouse development and cellular proliferation protein Cullin-7<br>The Cullin Ring Ligase family member, Cul7, is required for normal mouse development and cellular proliferation. Cul7 has a CPH domain which is a p53 interaction domain. The CPH domain interaction surface of P53 is present in the tetramerisation domain  .. 
+PF11516 Protein of unknown function (DUF3120)<br>This family of proteins with unknown function appears to be restricted to Bordetella.. 
+PF11517 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)<br>Nab2 is a yeast heterogeneous nuclear ribonucleoprotein that modulates poly(A) tail length and mRNA. This is the N terminal domain of the protein which mediates interactions with the C-terminal globular domain, Myosin-like protein 1 and the mRNA export factor, Gfd1  .The N-terminal domain of Nab2 shows a structure of a helical fold. The N terminal domain of Nab2 is thought to mediate protein protein interactions that facilitate the nuclear export of mRNA  . An essential hydrophobic Phe73 patch on the N terminal domain is thought to be a important component of the interface between Nab2 and Mlp1  .. 
+PF11518 Protein of unknown function (DUF3221)<br>This family of proteins with unknown function appears to be restricted to Bacillus. Some members in this family of proteins are annotated as YobA however this cannot be confirmed. YobA is a protein with unknown function.. 
+PF11519 Protein of unknown function (DUF3222)<br>This family of proteins with unknown function appears to be restricted to Rhodopseudomonas.. 
+PF11520 Chromatin protein Cren7<br>Cren7 is a chromatin protein found in Crenarchaeota and has a higher affinity for double-stranded DNA than for single-stranded DNA. The protein contains negative DNA supercoils and is associated with genomic DNA in vivo.Cren7 interacts with duplex DNA through a beta-sheet and a long flexible loop. The function has not been completely determined but it is thought that the protein may have a role similar to that of archaeal proteins in Euryarchaea  .. 
+PF11521 C-terminal general transcription factor TFIIE alpha<br>TFIIE is compiled of two subunits, alpha and beta. This family of proteins are the C terminal domain of the alpha subunit of the protein which is the largest subunit and contains several functional domains which are important for basal transcription and cell growth. The C terminal end of the protein binds directly to the amino-terminal PH domain of p62/Tfb1 (of IIH) which is involved in the recruitment of the general transcription factor IIH to the transcription preinitiation complex. P53 competes for the same binding site as TFIIE alpha which shows their structural similarity. Like p53, TFIIE alpha 336-439 can activate transcription in vivo  .. 
+PF11522 Yeast phosphatidylinositol-4-OH kinase Pik1<br>Pik1 is a regulator of membrane traffic and participates in the mating-pheromone signal-transduction cascade. The protein is localised to the nucleus and cytoplasm in the Golgi. Pik1 is thought to have an actin-independent role in membrane transport  .. 
+PF11523 Protein of unknown function (DUF3223)<br>This family of proteins has no known function.. 
+PF11524 Selenium binding protein<br>Selenium is an important nutrient that needs to be regulated since lack of the nutrient leads to cell abnormalities and high concentrations are toxic.\. SeBP regulates the level of free selenium in the cell by sequestering the nutrient during transport. SeBP acts as a pentamer and delivers the selenium to the selenophosphate synthetase enzyme  . Each subunit is composed of an alpha helix on top of a four stranded twisted ss sheet, stabilised by hydrogen bonds  .. 
+PF11525 Copper resistance protein K<br>CopK is a periplasmic dimeric protein which is strongly up-regulated in the presence of copper, leading to a high periplasmic accumulation  . CopK has two different binding sites for Cu(I), each with a different affinity for the metal. Binding of the first Cu(I) ion induces a conformational change of CopK which involves dissociation of the dimeric apo-protein. Binding of a second Cu(I) further increases the plasticity of the protein. CopK has features that are common with functionally related proteins such as a structure consisting of an all-beta fold and a methionine-rich Cu(I) binding site  .. 
+PF11526 Subunit of cleavage factor IA Pcf11<br>Pcf11 is a subunit of an essential polyadenylation factor in Saccharomyces cerevisiae, CFIA. Pcf11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery  .. 
+PF11527 The ARF-like 2 binding protein BART<br>BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterised  . BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1  .. 
+PF11528 Protein of unknown function (DUF3224)<br>This bacterial family of proteins has no known function.. 
+PF11529 Melampsora lini avirulence protein AvrL567-A<br>AvrL567-A is a protein from the fungal pathogen flax which induces plant disease resistance in flax plants  . The protein has a novel fold  .. 
+PF11530 Minor type IV pilin, PilX<br>PilX is a protein from Neissaria meningitidis which is crucial for the formation of bacterial aggregates and adhesion to human cells  . The structure of PilX is similar to all pilins as it has the common alpha/beta roll fold. PilX subunits have surface-exposed motifs which are thought to stabilise bacterial aggregates against pilus retraction. It also illustrates how a minor pilus component can modulate the virulence properties of pili which have a simple composition and structure  .. 
+PF11531 Coactivator-associated arginine methyltransferase 1 N terminal<br>CARM1 is an arginine methyltransferase which methylates a variety of different proteins and plays a role in gene expression. This is the N terminal domain of the protein which has a PH domain, normally present to regulate protein-protein interactions.A molecular switch is also present on the N terminal domain  .. 
+PF11532 Heterogeneous nuclear ribonucleoprotein M<br>HnRNP M is a splicing regulatory factor that binds to the auxiliary RNA cis-element ISE/ISS-2 which promotes splicing of exon IIIb and silencing of exon IIIC in the fibroblast growth factor receptor 2 (FGFR2)  . By binding to ISE/ISS-3, HnRNP M plays a role in the regulation of alternative splicing in FGFR2 as it induces exon skipping and promotes exon inclusion  .. 
+PF11533 Protein of unknown function (DUF3225)<br>This bacterial family of proteins has no known function.. 
+PF11534 Hexameric tyrosine-coordinated heme protein (HTHP)<br>HTHP is from the marine bacterium Silicibacter pomeroyi and has peroxidase and catalase activity. HTHP consists of six monomers which each binds a solvent accessible heme group and is stabilised by the interaction of three neighbouring monomers  . The heme iron is penta-coordinated with a tyrosine residue as proximal ligand  .. 
+PF11535 Calcium binding<br>CcbP is a Ca(2+) binding protein which, in Anabaena, is thought to bind Ca(2+) by protein surface charge. When bound to Ca(2+), the protein becomes more compact and the level of free calcium decreases. The free Ca(2+) concentration which is regulated by CcbP is critical for the differentiation process  . Calcium signalling is widespread in bacterial species, and prokaryotic cells like eukaryotes are equipped with all the elements to maintain Ca2+ homeostasis  .. 
+PF11536 Protein of unknown function (DUF3226)<br>This archaeal family of proteins has no known function.. 
+PF11537 Protein of unknown function (DUF3227)<br>This archaeal family of proteins has no known function.. 
+PF11539 Protein of unknown function (DUF3228)<br>This family of proteins has no known function.. 
+PF11538 Snurportin1<br>Snurportin1 is a novel nuclear import receptor which contains an N-terminal importin beta binding domain which is essential for its function of a snRNP-specific nuclear import receptor  . Snurportin1 interacts with m3G-cap where it enhances the m3G-cap dependent nuclear import of U snRNPs in Xenopus laevis oocytes and digitonin-permeabilized HeLa cells  .. 
+PF11540 Cytoplasmic dynein 1 intermediate chain 2<br>Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules  . IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex  . . 
+PF11542 Mitochondrial division protein 1<br>Mdv1 is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation  . Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependant devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly  .. 
+PF11543 Nuclear pore localisation protein NPL4<br>Npl4 is part of the heterodimer UN along with Ufd1 which is involved in the recruitment of p97, an AAA ATPase, for tasks involving the ubiquitin pathway. Npl4 has a ubiquitin-like domain which has within its structure a beta-grasp fold with a helical insert  .. 
+PF11544 Spindle pole body component Spc42p<br>Spc42p is a 42-kD component of the S.cerevisiae spindle body that localises to the electron dense central region of the SPB  .Spc42p is a phosphoprotein which forms a polymeric layer at the periphery of the SPB central plaque. This functions during SPB duplication and also facilitates the attachment of the SPB to the nuclear membrane  .. 
+PF11545 Cell surface heme-binding protein Shp<br>Shp is part of a complex which functions in heme uptake in Streptococcus pyogenes. During which, Shp transfers its heme to HtsA which is a component of an ABC transporter. The heme binding region of Shp contains an immunoglobulin-like beta-sandwich fold and has a unique heme-iron coordination with the axial ligands being two methionine residues from the same Shp molecule  . Surrounding the heme pocket, there is a negative surface which may serve as a docking interface for heme transfer  .. 
+PF11546 Staphylococcal complement inhibitor SCIN <br>SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface  . An 18 residue stretch 31-48 is crucial for SCIN activity  .. 
+PF11547 E3 ubiquitin ligase EDD<br>EDD, the ER ubiquitin ligase from the HECT ligases, contains an N-terminal ubiquitin-associated domain which binds ubiquitin. Ubiquitin is recognised by helices alpha-1 and -3 in in the UBA domain. EDD is involved in DNA damage repair pathways and binds to mono-ubiquitinated proteins  .. 
+PF11548 Protein-tyrosine phosphatase receptor IA-2<br>IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene  . The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism  .. 
+PF11549 Protein transport protein SEC31<br>Sec31 is involved in COPII coat formation as it forms through the sequential binding of three cytoplasmic proteins: Sar1, Sec23/24 and Sec13/31. Sec13/31 is recruited by the pre-budding complex and polymerisation of Sec13/31 occurs to form an octahedral cage that is the outer shell of the COPII coat  . Sec13/31 is a hetero-tetramer which is organised as a linear array of alpha-solenoid and beta-propeller domains to form a rod in which twenty-four copies assemble to form the COPII cub-octahedron  .. 
+PF11550 Intracellular growth locus C protein<br>IglC protein is involved in the escape of F.tularensis live vaccine strain  . It has been shown that the expression of IglC is essential for F.tularensis to induce macrophage apoptosis  . IglC adopts a beta-sandwich conformation that has no similarity to any known protein structure  .. 
+PF11551 Outer membrane protein Omp28<br>Omp28 is a 28-kDa outer membrane protein from Porphyromonas gingivalis. Omp28 is thought to be a surface adhesion/receptor protein. Omp28 is expressed in a wide distribution of P.gingivalis strains  .. 
+PF11553 Protein of unknown function (DUF3231)<br>This bacterial family of proteins has no known function.. 
+PF11554 Protein of unknown function (DUF3232)<br>This bacterial family of proteins has no known function.. 
+PF11555 EGFR receptor inhibitor Mig-6<br>When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains  .The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive  .. 
+PF11556 Erythrocyte binding antigen 175<br>EBA-175 is involved in the formation of a tight junction, a necessary step in invasion. This family represents the region VI which is a cysteine rich domain essential for EBA-175 trafficking. The structure is a homodimer that contains a five-alpha-helical core stabilised by four disulphide bridges  .. 
+PF11557 Protein of unknown function (DUF3233)<br>Pfam-B_5068 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11558 Het-s 218-289<br>This family of proteins is residues 218-289 of Het-s, a protein of Podospora anserina. Het-s plays a role in heterokaryon incompatibility which prevents different forms of parasitism  . This region of the protein is the C-terminal end and is unstructured in solution but forms infectious fibrils in vitro which has a structure consisting of a left-handed beta solenoid which contains two windings per molecule  .. 
+PF11559 Afadin- and alpha -actinin-Binding<br>This family is found in mammals where it is localised at cell-cell adherens junctions  , and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules  . It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.. 
+PF11560 Lamina-associated polypeptide 2 alpha<br>LAPs are components of the nuclear lamina which supports the nuclear envelope.LAP2alpha is a non-membrane-associated member of the LAP family which is unique. This family of proteins is the C terminal domain of LAP2alpha which consists of residues 459-693 and constitutes a dimeric structure with an antiparallel coiled coil. LAP2alpha is involved in cell-cycle regulation and chromatin organisation and preferentially binds to lamin A/C  .. 
+PF11561 Single strand annealing-weakened 1<br>This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyses the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates  .. 
+PF11563 Protoglobin<br>Pollington J, Eberhardt R. This family includes protoglobin from Methanosarcina acetivorans C2A. It is also found near the N-terminus of the Haem-based aerotactic transducer HemAT in Bacillus subtilis (Swiss:O07621). It is part of the haemoglobin superfamily. Protoglobin has specific loops and an amino-terminal extension which leads to the burying of the haem within the matrix of the protein. Protoglobin-specific apolar tunnels allow the access of O2, CO and NO to the haem distal site  . In HemAT it acts as an oxygen sensor domain  .. 
+PF11564 Restriction endonuclease BpuJI - N terminal<br>BpuJI is a restriction endonuclease which recognises the asymmetric sequence 5'-CCCGT and cuts at multiple sites in the surrounding area of the target sequence. This family of proteins is the N terminal domain of BpuJI which has DNA recognition functions. The recognition domain has two subdomains D1 and D2. The recognition of the target sequence occurs through major groove contacts of amino acids on the helix-turn-helix region and the N-terminal arm  .. 
+PF11565 Alpha helical Porin B<br>Porin B is a porin from Corynebacterium glutamicum which allows the exchange of material across the mycolic acid layer which is the protective nonpolar barrier. Porin B has an alpha helical core structure consisting of four alpha-helices surrounding a nonpolar interior. There is a disulphide bridge between helices 1 and 4 to form a stable covalently bound ring  . The channel of PorB is oligomeric  .. 
+PF11566 Inhibitor_PI31;<br>PI31 proteasome regulator N-terminal. PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces  . This is the N-terminal domain of the members.. 
+PF11567 Plasmodium falciparum UIS3 membrane protein<br>UIS3 is a membrane protein essential for sporozoite development in infected hepatocytes. This family is 130-229 of the Plasmodium falciparum UIS3 protein which is compact and has an all alpha-helical structure.PfUIS3(130-229) interacts with lipids, phospholipid lysosomes, the human liver fatty acid-binding protein and with the lipid phosphatidylethanolamine. The interaction with liver fatty acid-binding protein provides the parasite with a method to import essential fatty acids/lipids during rapid growth phases of sporozoites  .. 
+PF11568 Mediator complex subunit 29<br>Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function  . Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators  .. 
+PF11569 Homeodomain leucine-zipper encoding, Homez<br>Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus  . It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerisation and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain  . Homez is involved in a complex regulatory network  .. 
+PF11570 Coiled-coil receptor-binding R-domain of colicin E2<br>E2 is a DNase which utilises the outer membrane receptor BtuB to bind to and enter the cell. This family of proteins is E2R135 (residues 321-443) which is the part of E2 which is responsible for binding to BtuB in a coiled coil formation  .. 
+PF11571 Mediator complex subunit 27<br>Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function  . Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells  .. 
+PF11572 Protein of unknown function (DUF3234)<br>This bacterial family of proteins has no known function. Some members in this family of proteins are annotated as TTHA0547 however this cannot be confirmed.. 
+PF11573 Mediator complex subunit 23<br>Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.. 
+PF11574 Protein of unknown function (DUF3235)<br>Some members in this family of proteins with unknown function are annotated as RpfA however this cannot be confirmed.. 
+PF11575 FhuF 2Fe-2S C-terminal domain<br>Pfam-B_11690 (release 9.0). This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.\.      FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B  .  This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster  .. 
+PF11576 Protein of unknown function (DUF3236)<br>This family of proteins with unknown function appears to be restricted to Methanobacteria.. 
+PF11577 NF-kappa-B essential modulator NEMO<br>NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation  . NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK  .. 
+PF11578 Protein of unknown function (DUF3237)<br>This family of proteins has no known function. 
+PF11579 Protein of unknown function (DUF3238)<br>This family of proteins with unknown function appears to be restricted to Bacillus cereus.. 
+PF11580 Protein of unknown function (DUF3239)<br>This bacterial family of proteins may be membrane proteins however this cannot be confirmed. Currently there is no known function.. 
+PF11581 Antagonist of EGFR signalling, Argos<br>Argos is a natural secreted antagonist of EGFR signalling which functions by binding growth factor ligands that activate EGFR by forming a clamp like structure using three disulphide-bonded beta-sheet domains  .. 
+PF11582 Protein of unknown function (DUF3240)<br>This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11583 P-aminobenzoate N-oxygenase AurF<br>AurF is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalysing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes  .. 
+PF11584 Proteinaceous host-selective toxin ToxA<br>ToxA is produced by particular Pyrenophora tritici-repentis races and is a proteinaceous host-selective toxin. It is necessary and sufficient to cause cell death in sensitive wheat cultivars  .ToxA adopts a single-domain, beta-sandwich fold which has novel topology. The protein is directly involved in recognition events required for ToxA action. It is thought to be distantly related to FnIII proteins, gaining entry to the host via an integrin-like receptor  .. 
+PF11585 Insect antimicrobial peptide, stomoxyn<br>Stomoxyn, localised in the gut epithelium, is an insect antimicrobial peptide which functions in killing a range of microorganisms, parasites and some viruses. Stomoxyn has a structure consisting of a random coil in water however in TFE it adopts a stable helical structure. Stomoxyn is thought to have a similar function to cecropin A from Hyalophora cecropia due to structural similarities  .. 
+PF11586 Protein of unknown function (DUF3242)  <br>This protein from Thermotoga maritima is a hypothetical ORFan protein, TM1622, whose structure has been determined. The protein is composed of seven beta strands and three alpha helices  .. 
+PF11587 Major prion protein bPrPp - N terminal<br>This family represents the N-terminal domain (1-30) of the bovine prion protein (bPrPp). The proteins structure consists of mainly alpha helices. BPrPp forms a stable helix which inserts in a transmembrane location in the bilayer, with the N -terminal (1-30) functioning as a cell-penetrating peptide  .. 
+PF11588 Protein of unknown function (DUF3243)<br>This family of proteins with unknown function appears to be restricted to Firmicutes.. 
+PF11589 Domain of unknown function (DUF3244)<br>This domain adopts an immunoglobulin-like beta-sandwich fold  and structurally is most similar to fibronectin.. 
+PF11590 DNA polymerase catalytic subunit Pol<br>This family of proteins represents the catalytic subunit, Pol, of the Herpes simplex virus DNA polymerase. Pol binds UL42, making up the DNA polymerase. UL42 is a processivity subunit which binds to the C-terminal of Pol in a similar way that the cell cycle regulator p21 binds to PCNA  .. 
+PF11591 Ferredoxin chloroplastic transit peptide<br>The structure of chloroplast ferredoxin in water is unstructured however in a 30:70 molar-ratio mixture of 2,2,2-trifluoroethanol, residues 3 to 13 form an alpha-helix. The rest of the peptide remains unstructured  . This family is the N-terminal of the [2Fe-2S) ferredoxin from C.reinhardtii. This protein catalyses the final reaction in a pathway which allows the production of H(2) from water in the chloroplast  . . 
+PF11592 Central core of the bacterial effector protein AvrPto<br>This family of proteins represents the bacterial effector protein AvrPto from Pseudomonas syringae. This is the central core region of the protein which consists of a three-helix bundle motif. AvrPto is part of a type III secretion system from P.syringae which is involved in the bacterial speck disease of tomato. In resistant plants, AvrPto interacts with the host Pto kinase, which elicits an antibacterial defense response. In plants lacking resistance, the Pto kinase is not present and AvrPto acts as a virulence factor, promoting bacterial growth  .. 
+PF11593 Mediator complex subunit 3 fungal<br>Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function  . Mediator subunit Hrs1/Med3 is a physical target for Cyc8-Tup1, a yeast transcriptional co-repressor  .. 
+PF11594 Mediator complex subunit 28<br>Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function  . Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours  .. 
+PF11595 Protein of unknown function (DUF3245)<br>This is a family of proteins conserved in fungi. The function is not known, and there is no S. cerevisiae member.. 
+PF11596 Protein of unknown function (DUF3246)<br>This is a small family of fungal proteins one of whose members, Swiss:A3LUS4 from Pichia stipitis is described as being an extremely serine rich protein-mucin-like protein.. 
+PF11597 Mediator complex subunit 13 N-terminal<br>Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood  .. 
+PF11598 Cartilage oligomeric matrix protein<br>This family of proteins represents the five-stranded coiled-coil domain of cartilage oligomeric matrix protein (COMP). This region has a binding site between two internal rings formed by Leu37 and Thr40  . 
+PF11599 RRNA methyltransferase AviRa<br>This family of proteins represents the methyltransferase AviRa from Streptomyces viridochromogenes. This protein mediates the resistance to the antibiotic avilamycin. AviRa methylates a specific guanine base within the peptidyl-transferase loop of the 23S ribosomal RNA  .. 
+PF11600 Chromatin assembly factor 1 complex p150 subunit, N-terminal<br>CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesised and acetylated histones H3/H4 into chromatin during DNA replication and repair  . CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesised and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis  .. 
+PF11601 Shal-type voltage-gated potassium channels <br>This family of proteins represents Shal-type voltage-gated potassium channels which interact with Kv channel-interacting proteins to modulate cell surface expression and function of Kv4 channels. The interaction of the Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs  .. 
+PF11602 ATPase P4 of dsRNA bacteriophage phi-12<br>P4 is a packaging motor which is involved in the packaging of phi-12 genome into preformed capsids using ATP. P4 is located at the vertices of the icosahedral capsid. ATP drives RNA translocation through cooperative conformational changes  .. 
+PF11603 Regulatory protein Sir1<br>Sir1p interacts with the BAH domain of the Orc1p subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae  . The amino acids from the ORC interaction region of Sir1p are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing  .. 
+PF11604 Copper binding periplasmic protein CusF<br>CusF is a periplasmic protein involved in copper and silver resistance in Escherichia coil. CusF forms a five-stranded beta-barrel OB fold. Cu(I) binds to H36, M47 and M49 which are conserved residues in the protein  .. 
+PF11605 Vacuolar protein sorting protein 36 Vps36<br>Vps36 is a subunit of ESCRT-II, a protein involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late endosomes  .. 
+PF11606 Family 31 carbohydrate binding protein<br>This family of proteins represents the family 31 carbohydrate-binding module of beta-1,2-xylanase. This protein is from Alcaligenes sp. strain XY-234. The AlcCBM31 module makes a beta-sandwich structure with an immunoglobulin fold and contains two intra-molecular disulfide bonds. AlcCBM31 shows affinity with only beta-1,3-xylan  .. 
+PF11607 Protein of unknown function (DUF3247)<br>This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions  .. 
+PF11608 Limkain b1<br>This family of proteins represents Limkain b1, which is a novel human autoantigen, localised to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures  .. 
+PF11609 Protein of unknown function (DUF3248)<br>This family of proteins is thought to be the product of the gene TT1592 from Thermus thermophilus however this cannot be confirmed. Currently there is no known function.. 
+PF11610 Scaffold protein Ste5-Fus5 binding region<br>This family of proteins represents the Fus5 binding region of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mitogen-activated protein kinase. Auto-activated Fus3 has a negative regulatory role, and promotes Ste5 phosphorylation which leads to a decrease in pathway transcriptional output  .. 
+PF11611 TRF2;<br>Domain of unknown function (DUF4352). Members of these family are poutative lipoproteins that fall into the Antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily.. 
+PF11612 GspJ;<br>Type II secretion system (T2SS), protein J. Pollington J, Desvaux M. The T2SJ proteins are pseudopilins, which are targeted to the membrane in E. Coli. T2SJ forms a complex with T2SI (Pfam:PF02501) and T2SK (Pfam:PF03934) which is part of the Type II secretion apparatus involved in the translocation of proteins across the outer membrane in E.coli. The T2SK-I-J complex has quasihelical characteristics  .. 
+PF11613 Agonist of corticotropin releasing factor R2, Urocortin-2<br>This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif  .. 
+PF11614 Bre5;<br>IG-like fold at C-terminal of FixG, putative oxidoreductase. Pollington J, Coggill P. This domain is part of a transmembrane protein, FixG, itself part of the FixGHIS operon closely associated with the FixNOPQ operon that is the symbiotically essential cbb3-type haem-copper oxidase complex. FixG expression is induced by oxygen-deprivation. This C-terminal domain adopts an E-set Ig-like fold.. 
+PF11615 Protein of unknown function (DUF3249)<br>This family of proteins represents the gene product of the protein CAF4, the yeast protein YKR036c. This protein contains seven WD40 repeats in its C terminus. The function however is unknown  .. 
+PF11616 WD repeat binding protein EZH2<br>This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression  . This interaction is required for the HMTase activity of PCR2  .. 
+PF11617 Protein metal binding site<br>This family of proteins represents a unique protein copper binding site that involves a tryptophan metabolite, kynurenine in the protein MopE. The production of kyneurenin by modification of tryptophan and its involvement in copper binding is an innate property of MopE  .. 
+PF11618 Protein of unknown function (DUF3250)<br>This family of proteins represents a protein with unknown function. It may be the C2 domain from KIAA1005 however this cannot be confirmed.. 
+PF11619 Transcription factor P53 - C terminal domain<br>This family of proteins is the C terminal domain of the transcription factor P53. While the rest of the protein is quite conserved between the different transcription factors such as p53 and p73, the C terminal domain is highly divergent. The DM-p53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix  .. 
+PF11620 GA-binding protein alpha chain<br>This family of proteins represents the transcription factor GABP alpha. This alpha domain is a five-stranded beta-sheet crossed by a distorted helix termed an OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300, a direct link between GABP and transcriptional machinery has been made  .. 
+PF11621 C3 binding domain 4 of IgG-bind protein SBI<br>This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation  . When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold  .. 
+PF11622 Protein of unknown function (DUF3251)<br>This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. Some members if this family are annotated as putative lipoprotein YajI however this cannot be confirmed.. 
+PF11623 Protein of unknown function (DUF3252)<br>This family of proteins has no known function. Some members are annotated as Ssl0352 however this cannot be confirmed. Currently there is no known function.. 
+PF11624 MHC class I-like protein M157<br>This family of proteins represents M157,a divergent form of MHC class I-like proteins which is the protein product of the mouse cytomegalovirus. This protein is unique in its ability to engage both activating (Ly49H) and inhibitory (Ly49I) natural killer cell receptors. M157 is involved in intra- and intermolecular interacts within and between its domains to form a compact MHC-like molecule  .. 
+PF11625 Protein of unknown function (DUF3253)<br>This bacterial family of proteins has no known function.. 
+PF11626 Rap1_C; TRF2IP; Yippee-Rap1;<br>TRF2-interacting telomeric protein/Rap1 - C terminal domain. This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres  . The Rap-1 C terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C terminal domain  . Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends from attack by DNA-repair mechanisms [2,3,4,5].. 
+PF11627 Nuclear factor hnRNPA1<br>This family of proteins represents hnRNPA1, a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins are involved in numerous RNA-related activities  .. 
+PF11628 T-cell surface glycoprotein CD3 zeta chain<br>The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues  . The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerisation and assembly with TCR  .. 
+PF11629 C terminal SARAH domain of Mst1<br>This family of proteins represents the C terminal SARAH domain of Mst1. SARAH controls apoptosis and cell cycle arrest via the Ras, RASSF, MST pathway. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process  .. 
+PF11630 Protein of unknown function (DUF3254)<br>This family of proteins is most likely a family of anti-lipopolysaccharide factor proteins however this cannot be confirmed.. 
+PF11631 Protein of unknown function (DUF3255)<br>Members in this family of proteins are annotated as YxeF however no function is currently known. The family appears to be restricted to Bacillus.. 
+PF11632 Lactococcin G-beta<br>This family of proteins is LcnG-beta, which with LcnG-alpha constitute the two-peptide bacteriocin lactococcin G (LcnG). This family of proteins represents the N terminal domain which has an alpha-helical structure and is amphiphilic. Both peptides have a GxxxG motif which they use for interaction through a helix-helix structure  .. 
+PF11633 Nsp3;<br>Single-stranded poly(A) binding domain. This family of proteins represents Nsp3c, the product of ORF1a in group 2 coronavirus. The domain exhibits a macrodomain fold containing the nsp3 residues 528 to 648, with a flexibly extended N-terminal tail from residues 513 to 527 and a C-terminal flexible tail of residues 649 to 651. SUD-M(527-651) binds single-stranded poly(A); the contact area with this RNA on the protein surface, and the electrophoretic mobility shift assays confirm that SUD-M has higher affinity for purine bases than for pyrimidine bases.. 
+PF11634 Nuclease inhibitor from bacteriophage T4<br>This family of proteins represents IPI from bacteriophage T4. This protein is a nuclease inhibitor which is injected by T4 to protect its DNA from gmrS/gmrD CT of pathogenic Escherichia coli into the infected host  . The structure of this protein consists of two small beta-sheets flanked by N and C termini by alpha-helices. The protein has a gmrS/gmrD hydrophobic binding site  .. 
+PF11635 Mediator complex subunit 16<br>Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function.\.   Med16 is one of the subunits of the Tail portion of the Mediator complex and is required for lipopolysaccharide gene-expression  . Several members including the human protein, Swiss:Q9Y2X0, have one or more WD40 domains on them, Pfam:PF00400.. 
+PF11636 Troponin I residues 1-32<br>This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity  . . 
+PF11637 ATP-dependant DNA helicase UvsW<br>This family of proteins represents the DNA helicase UvsW from bacteriophage T4. The protein is a member of the monomeric SF2 helicase superfamily and shows structural homology to the eukaryotic SF2 helicase Rad54. UvsW is thought to have a role in recombination and the rescue of stalled replication forks  .. 
+PF11638 DnaA N-terminal domain<br>pdb_2jmp & Jackhmmer:B3CS04. This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known  . It is also found in three copies in some proteins such as Swiss:B5V0X4. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerisation.. 
+PF11639 REDY-like protein HapK<br>This family of proteins represents HapK, a protein of unknown function, with two homologues PigK and RedY. The monomer structure of the protein contains a four-stranded anti parallel beta-sheet, three alpha-helices and a short C terminal tail which it uses for dimer formation  . The surface of HapK has a deep cavity with consists of a kinked helix and a beta-four strand. HapK could be involved in prodigiosin biosynthesis, specifically the binding of a bipyrrole intermediate such as HBM or MBM  .. 
+PF11640 Telomere-length maintenance and DNA damage repair<br>Pfam-B_6865 (release 23.0). ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage  . It is classified as an EC:2.7.11.1.. 
+PF11641 Glycosylphosphatidylinositol-anchored merozoite surface protein<br>This family of proteins represents the core region of Bd37, a surface antigen of B.divergens which is GPI-anchored at the surface of the merozoite. The structure of the protein consists of mainly alpha folds and has three sub domains  .. 
+PF11642 Mite allergen Blo t 5<br>This family of proteins is Blo t 5, an allergen protein from Blomia tropicalis mites. This protein shoes strong reactivity with IgE in asthmatic and rhinitis patients. The structure of the protein contains three alpha helices which form a coiled-coil  .. 
+PF11644 Protein of unknown function (DUF3256)<br>This family of proteins with unknown function appears to be restricted to Bacteroidales.. 
+PF11645 DUF3257;<br>PD-(D/E)XK endonuclease. This family of endonucleases includes a group I intron-encoded endonuclease  . This family belongs to the PD-(D/E)XK superfamily [2-3].. 
+PF11646 Protein of unknown function DUF3258<br>This viral family are possible phage integrase proteins however this cannot be confirmed.. 
+PF11647 C-terminal region of Pasteurella multocida toxin residues 569-1285<br>This family represents the C terminal region of Pasteurella multocida toxin (PMT) which displays a Trojan horse-like shape with three domains, C1, C2 and C3. The C3 domain possesses the Cys-His-Asp catalytic triad. PMT is an enzyme toxin carrying the cysteine protease-like catalytic triad which functions on the cytoplasmic face of the plasma membrane of target cells  .. 
+PF11648 C-terminal domain of RIG-I<br>This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerisation. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity  .. 
+PF11649 Virus neck protein<br>This family of protein represents gene product 14, a major component of the neck in T4-like viruses along with gene product 13. Gene product 14 is rich is beta-sheets. The formation of the neck to the head of the bacteriophage is crucial for the tail attachment  .. 
+PF11650 P22 tail accessory factor<br>This tail accessory factor of the P22 virus is also referred to as gene product 4 (Gp4). The proteins structure consists of 60% alpha helices. Gp4 is the first tail accessory factor to be added to newly DNA-filled capsids during P22-morphogenesis. In solution, the protein acts as a monomer and has low structural stability. The interaction of gp4 with the portal protein involves the binding of two non-equivalent sets of six gp4 proteins  . Gp4 acts as a structural adaptor for gp10 and gp26, the other tail accessory factors  .. 
+PF11651 P22 coat protein - gene protein 5<br>This family of proteins represents gene product 5 from bacteriophage P22. This protein is involved in the formation of the pro-capsid shells in the bacteriophage. In total, there are 415 molecules of the coat protein which are arranged in an icosahedral shell  .. 
+PF11652 Protein of unknown function (DUF3259)<br>This eukaryotic family of proteins has no known function.. 
+PF11653 Bacteriophage T7 virion assembly protein<br>This family of proteins represents the gene product 7.3 from T7 bacteriophage. The protein is localised to the tail and is thought to be important in virion assembly. Particles assembled in the absence of the protein fail to adsorb to cells  .. 
+PF11654 Protein of unknown function (DUF2665)<br>Some members in this family are annotated as Non classical export proteins, however no specific function is known.. 
+PF11655 Protein of unknown function (DUF2589)   <br>This family of proteins has no known function.. 
+PF11656 ComReg_Spx;<br>YjbD family (DUF3811). This is a family of proteobacteria proteins of unknown function. This family is unrelated to Pfam:PF03960 which contains a set of transcription factors that are also named YjbD.. 
+PF11657 Transcriptional activator TraM <br>TraM is required for quorum dependence. It binds to and in-activates TraR which controls the replication of the tumour-inducing virulence plasmid. TraM interacts in a two-step process with DNA-TraR to form a large, stable anti-activation complex [1,2].. 
+PF11658 Protein of unknown function (DUF3260)<br>Pfam-B_003054 (release 23.0). Some members in this family of proteins are annotated as YhjU however this cannot be confirmed. Currently this family has no known function.. 
+PF11659 Protein of unknown function (DUF3261)<br>Pfam-B_003077 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11660 Protein of unknown function (DUF3262)<br>Pfam-B_003096 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11661 Protein of unknown function (DUF2986)<br>Pfam-B_003109 (release 23.0). This family of proteins has no known function.. 
+PF11662 Protein of unknown function (DUF3263)<br>Pfam-B_003189 (release 23.0). This family of proteins with unknown function appears to be restricted to Actinobacteria.. 
+PF11663 Toxin with endonuclease activity YhaV<br>Pfam-B_003231 (release 23.0). YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity  .. 
+PF11665 Protein of unknown function (DUF3265)<br>Pfam-B_001494 (release 23.0). This family of proteins with unknown function appear to be restricted to Vibrio.. 
+PF11666 Protein of unknown function (DUF2933)<br>Pfam-B_002197 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11667 Protein of unknown function (DUF3267)<br>Pfam-B_002418 (release 23.0). This family of proteins has no known function.. 
+PF11668 HCMV glycoprotein pUL130<br>Pfam-B_002736 (release 23.0). This family of proteins represents pUL130 from Human cytomegalovirus, a glycoprotein secreted from infected cells that is incorporated into the virion envelope as a Golgi-matured form. The protein promotes endothelial cell infection through a producer cell modification of the virion  .. 
+PF11669 WW domain-binding protein 1<br>Pfam-B_003402 (release 23.0). This family of proteins represents WBP-1, a ligand of the WW domain of Yes-associated protein. This protein has a proline-rich domain. WBP-1 does not bind to the SH3 domain  .. 
+PF11670 Major surface protein 1a (MSP1a)<br>Pfam-B_001532 (release 23.0). MSP1a is part of the A.marginale major surface protein 1 (MSP1) complex and exists as a heterodimer with MSP1b. The complex has adhesive functions in bovine erythrocytes invasion  .. 
+PF11671 Complementary sex determiner protein<br>Pfam-B_4678 (release 23.0). This family of proteins represents the complementary sex determiner in the honeybee. In the honeybee, the mechanism of sex determination depends on the csd gene which produces an SR-type protein. Males are homozygous while females are homozygous for the csd gene. Heterozygosity generates an active protein which initiates female development  .. 
+PF11672 Protein of unknown function (DUF3268)<br>Pfam-B_4693 (release 23.0). This family of proteins has no known function.. 
+PF11673 Protein of unknown function (DUF3269)<br>Pfam-B_4706 (release 23.0). This family of proteins has no known function.. 
+PF11674 Protein of unknown function (DUF3270)<br>Pfam-B_4714 (release 23.0). This family of proteins with unknown function appears to be restricted to Streptococcus.. 
+PF11675 Protein of unknown function (DUF3271)<br>Pfam-B_4697 (release 23.0). This family of proteins with unknown function appears to be restricted to Plasmodium.. 
+PF11676 Protein of unknown function (DUF3272)<br>Pfam-B_4726 (release 23.0). This family of proteins with unknown function appears to be restricted to Streptococcus.. 
+PF11677 Protein of unknown function (DUF3273)<br>Pfam-B_4727 (release 23.0). Some members in this family of proteins are annotated as multi-transmembrane proteins however this cannot be confirmed. Currently this family has no known function.. 
+PF11678 Protein of unknown function (DUF3274)<br>Pfam-B_4733 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11679 Protein of unknown function (DUF3275)<br>Pfam-B_4743 (release 23.0). This family of proteins with unknown function appear to be restricted to Proteobacteria.. 
+PF11680 Protein of unknown function (DUF3276)<br>Pfam-B_4744 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11681 Protein of unknown function (DUF3277)<br>Pfam-B_4749 (release 23.0). This family of proteins represents a putative bacteriophage protein. No function is currently known.. 
+PF11682 Protein of unknown function (DUF3279)<br>Pfam-B_4753 (release 23.0). This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.. 
+PF11683 Protein of unknown function (DUF3278)<br>Pfam-B_4766 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11684 Protein of unknown function (DUF2380)<br>Pfam-B_4754 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11685 Protein of unknown function (DUF3281)<br>Pfam-B_4757 (release 23.0). This family of bacterial proteins has no known function.. 
+PF11686 Protein of unknown function (DUF3283)<br>Pfam-B_4778 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11687 Domain of unknown function (DUF3284)<br>Pfam-B_4781 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes.. 
+PF11688 Protein of unknown function (DUF3285)<br>Pfam-B_4791 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11690 Protein of unknown function (DUF3287)<br>Pfam-B_4801 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11691 Protein of unknown function (DUF3288)<br>Pfam-B_4815 (release 23.0). This family of proteins with unknown function appears to be restricted to Cyanobacteria.. 
+PF11692 Protein of unknown function (DUF3289)<br>Pfam-B_4824 (release 23.0). This family of proteins with unknown function appears to be restricted to Proteobacteria.. 
+PF11693 Protein of unknown function (DUF2990)<br>Pfam-B_4826 (release 23.0). This family of proteins represents a fungal protein with unknown function.. 
+PF11694 Protein of unknown function (DUF3290)<br>Pfam-B_4838 (release 23.0). This family of proteins with unknown function appears to be restricted to Firmicutes.. 
+PF11695 Domain of unknown function (DUF3291)<br>Pfam-B_4872 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11696 Protein of unknown function (DUF3292)<br>Pfam-B_4874 (release 23.0). This eukaryotic family of proteins has no known function.. 
+PF11697 Protein of unknown function (DUF3293)<br>Pfam-B_4879 (release 23.0). This bacterial family of proteins has no known function.. 
+PF11698 V-ATPase subunit H<br>Pfam-B_2481 (release 6.5). The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer.  This domain corresponds to the C terminal domain of the H subunit of V-ATPase.  The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation  .. 
+PF11699 Mif2;<br>CENP-C_C is a C-terminal family of fungal and eukaryote proteins necessary for centromere formation. CENP-C is the inner-kinetochore centromere (CEN) binding protein.  In the budding-yeast, Mif2, the yeast homologue, binds in the CDEIII region of the centromere, and has been shown to recruit a substantial subset of all inner and outer kinetochore proteins  . Mif2 adopts a cupin fold and is extremely similar both in polypeptide chain conformation and in dimer geometry to the dimerisation domain of a bacterial transcription factor  . The Mif2 dimer appears to be part of an enhanceosome-like structure that nucleates kinetochore assembly in budding yeast  . This C-terminal domain is the region via which CENP-C localises to centromeres throughout the cell cycle 2,3].. 
+PF11700 Vacuole effluxer Atg22 like<br>Pfam-B_14077 (release 22.0). Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy  .  This family also includes other transporter proteins.. 
+PF11701 Myosin-binding striated muscle assembly central<br>The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats Pfam:PF00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organised myofibrils  . The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins  . Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known  .. 
+PF11702 Protein of unknown function (DUF3295)<br>This family is conserved in fungi but the function is not known.. 
+PF11703 UPF0506<br>This uncharacterised family is found in Schistosoma genomes. Although uncharacterised it appears to belong to the knottin fold. The sequence is composed of two repeats of a 6 cysteine motif.. 
+PF11704 Vesicle coat protein involved in Golgi to plasma membrane transport<br>Pfam-B_3276 (release 23.0), ADDA_17305. In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex  . Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterised by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases  .. 
+PF11705 DNA-directed RNA polymerase III subunit Rpc31<br>Pfam-B_203281 (release 23.0). RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain  .. 
+PF11706 CGNR zinc finger<br>Pfam-B_19432 (release 10.0). This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.. 
+PF11707 Ribosome 60S biogenesis N-terminal<br>Pfam-B_2493 (release 23.0). Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits  . The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre  . The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.. 
+PF11708 Pre-mRNA splicing Prp18-interacting factor<br>Pfam-B_999 (release 23.0). The spliceosome, an assembly of snRNAs (U1, U2, U4/U6, and U5) and proteins, catalyses the excision of introns from pre-mRNAs in two successive trans-esterification reactions. Step 2 depends upon integral spliceosome constituents such as U5 snRNA and Prp8 and non-spliceosomal proteins Prp16, Slu7, Prp18, and Prp22. ATP hydrolysis by the DEAH-box enzyme Prp16 promotes a conformational change in the spliceosome that leads to protection of the 3'ss from targeted RNase H cleavage. This change, which probably reflects binding of the 3'ss PyAG in the catalytic centre of the spliceosome, requires the ordered recruitment of Slu7, Prp18, and Prp22 to the spliceosome. There is a close functional relationship between Prp8, Prp18, and Slu7, and Prp18 interacts with Slu7, so that together they recruit Prp22 to the spliceosome. Most members of the family carry a zinc-finger of the CCHC-type upstream of this domain.. 
+PF11709 Mitochondrial ribosomal protein subunit <br>Pfam-B_4972 (release 23.0). This family is the mitochondrial ribosomal small-subunit protein Mrp51. Its function is not entirely clear, but deletion of the MRP51 gene completely blocked mitochondrial gene expression.. 
+PF11710 G protein-coupled glucose receptor regulating Gpa2<br>Pfam-B_11657 (release 23.0). Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail  . This is the conserved N-terminus of these proteins, and the C-terminal conserved region is now in family Git3_C.. 
+PF11711 Inner membrane protein import complex subunit Tim54<br>Pfam-B_3533 (release 23.0). Mitochondrial function depends on the import of hundreds of different proteins synthesised in the cytosol. Protein import is a multi-step pathway which includes the binding of precursor proteins to surface receptors, translocation of the precursor across one or both mitochondrial membranes, and folding and assembly of the imported protein inside the mitochondrion. Most precursor proteins carry amino-terminal targeting signals, called pre-sequences, and are imported into mitochondria via import complexes located in both the outer and the inner membrane (IM). The IM complex, TIM, is made up of at least two proteins which mediate translocation of proteins into the matrix by removing their signal peptide and another pair of proteins, Tim54 and Tim22, that insert the polytopic proteins, that carry internal targetting information, into the inner membrane  .. 
+PF11712 Endoplasmic reticulum-based factor for assembly of V-ATPase<br>Pfam-B_2410 (release 23.0). The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterised member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localised to the endoplasmic reticulum  .. 
+PF11713 Peptidase C80 family<br>This family belongs to cysteine peptidase family C80.. 
+PF11714 Thrombin inhibitor Madanin  <br>Members of this family are the peptidase inhibitor madanin proteins. These proteins were isolated from tick saliva  .. 
+PF11715 Nucleoporin Nup120/160<br>Pfam-B_1841 (release 23.0). Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth  . The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export  . Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 subcomplex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 subcomplex, but rather that it regulates the association of the subcomplex with the NPC and other proteins  .. 
+PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain<br>
+PF11717 RNA binding activity-knot of a chromodomain <br>Pfam-B_4165 (release 22.0). This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding  .. 
+PF11718 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term<br>Pfam-B_2254 (release 23.0). This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins. The exact function of this domain is not known.. 
+PF11719 DNA replication and checkpoint protein<br>Pfam-B_1966 (release 23.0). Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent relicensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5  . Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication  .. 
+PF11720 Peptidase inhibitor I78 family<br>This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.. 
+PF11721 Di-glucose binding within endoplasmic reticulum<br>Pfam-B_783 (release 23.0) pdb_2jwp. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186.  NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan  .. 
+PF11722 CCCH zinc finger in TRM13 protein<br>This domain is found at the N-terminus of TRM13 methyltransferase proteins. It is presumed to be a zinc binding domain.. 
+PF11723 Homotrimeric ring hydroxylase<br>Pfam-B_24837 (release 22.0). This domain is found on aromatic hydroxylating enzymes such as 2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas putida and carbazole 1,9a-dioxygenase from Janthinobacterium. These enzymes are homotrimers and are distantly related to the typical oxygenase  .  This domain is found C terminal to the Rieske domain which binds an iron-sulphur cluster.. 
+PF11724 YvbH-like oligomerisation region<br>This region is found at the C-terminus of a group of bacterial PH domains. This region is composed of a helical hairpin that appears to mediate oligomerisation based on the known structure. This elaboration of the bacterial PH domain is only found in Bacillales.. 
+PF11725 Pathogenicity factor<br>Pfam-B_735 (release 23.0). This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system  . The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas  .. 
+PF11726 Protein of unknown function (DUF3296)<br>Pfam-B_768 (release 23.0). This family is expressed in Gammaproteobacteria. One of the E coli members is annotated as yagK, but otherwise the function is not known.. 
+PF11727 Invariant surface glycoprotein<br>Pfam-B_785 (release 23.0). This family is found in Trypanosome species, and appears to be one of two invariant surface glycoproteins, ISG65 and ISG75. that are found in the mammalian stage of the parasitic protozoan. the sequence suggests the two families are polypeptides with N-terminal signal sequences, hydrophilic extracellular domains, single trans-membrane alpha-helices and short cytoplasmic domains. they are both expressed in the bloodstream form but not in the midgut stage. Both polypeptides are distributed over the entire surface of the parasite [1,2].. 
+PF11728 DUF939 C-terminal domain<br>This region is a presumed intracellular domain found in a set of bacterial presumed transporter proteins. The region is about 160 amino acids in length.. 
+PF11729 nodavirus capsid protein <br>Pfam-B_805 (release 23.0). The capsid or coat protein of this family is expressed in Nodaviridae, that are ssRNA positive-strand viruses, with no DNA stage. These viruses are the causative agents of viral nervous necrosis in marine fish.. 
+PF11730 Protein of unknown function (DUF3297)<br>Pfam-B_797 (release 23.0). This family is expressed in Proteobacteria and Actinobacteria. The function is not known.. 
+PF11731 Pathogenicity locus<br>Pfam-B_826 (release 23.0). Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria  . Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.. 
+PF11732 Transcription- and export-related complex subunit<br>Pfam-B_819 (release 23.0). The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats  . In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex  .. 
+PF11733 Non-capsid protein NP1<br>Pfam-B_837 (release 23.0). This family is the non-capsid protein NP1 of the ssDNA, Parvovirinae virus Bocavirus of cattle and humans.. 
+PF11734 TilS substrate C-terminal domain<br>This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.. 
+PF11735 Cryptococcal mannosyltransferase 1 <br>Pfam-B_916 (release 23.0). The capsule of pathogenic fungi is a complex polysaccharide whose formation is determined by a number of enzymes including, most importantly, alpha-1,3-mannosyltransferase 1, EC:2.4.1.-  .. 
+PF11736 Protein of unknown function (DUF3299)<br>Pfam-B_876 (release 23.0). This is a family of bacterial proteins of unknown function.. 
+PF11737 Protein of unknown function (DUF3300)<br>Pfam-B_886 (release 23.0). This hypothetical bacterial gene product has a long hydrophobic segment and is thus likely to be a membrane protein.. 
+PF11738 Protein of unknown function (DUF3298)<br>Pfam-B_854 (release 23.0). This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.. 
+PF11739 Dicarboxylate transport<br>Pfam-B_935 (release 23.0). In certain bacterial families this protein is expressed from the ydbH gene, and there is a suggestion that this is a form of DctA or dicarboxylate transport protein. Dicarboxylate transport proteins are found in aerobic bacteria which grow on succinate or other C4-dicarboxylates  .. 
+PF11740 Plasmid replication region DNA-binding N-term<br>Pfam-B_844 (release 23.0). The broad host-range plasmid RK2 is able to replicate in and be inherited in a stable manner in diverse Gram-negative bacterial species. It encodes a number of co-ordinately regulated operons including a central control korF1 operon that represses the kfrA operon. The KfrA polypeptide is a site-specific DNA-binding protein whose operator overlaps the kfrA promoter. The N-terminus, containing an helix-turn-helix motif, is essential for function. Downstream from this family is an extended coiled-coil domain containing a heptad repeat segment which is probably responsible for formation of multimers, and may provide an example of a bridge to host structures required for plasmid partitioning  .. 
+PF11741 AMIN domain<br>Pfam-B_11438 (release 23.0). This N-terminal domain of various bacterial protein families is crucial for the targetting of periplasmic or extracellular proteins to specific regions of the bacterial envelope. AMIN is derived from the N-terminal domain of AmiC, an N-acetylmuramoyl-l-alanine amidase of Escherichia coli which localises to the septal ring during division and plays a key role in the separation of daughter cells.  The AMIN domain is present in several protein families besides amidases suggesting that AMIN may represent a general targetting determinant involved in the localisation of periplasmic protein complexes  .. 
+PF11742 Protein of unknown function (DUF3302)<br>Pfam-B_953 (release 23.0). This family of unknown function is expressed by proteobacteria.. 
+PF11743 Protein of unknown function (DUF3301)<br>Pfam-B_952 (release 23.0). This family is conserved in Proteobacteria, but the function is not known.. 
+PF11744 Aluminium activated malate transporter<br>
+PF11745 Protein of unknown function (DUF3304)<br>Pfam-B_956 (release 23.0). This is a family of bacterial proteins of unknown function.. 
+PF11746 Protein of unknown function (DUF3303)<br>Pfam-B_958 (release 23.0). Several members are annotated as being LysM domain-like proteins, but these did not match any LysM domains reported in the literature.. 
+PF11747 Killing trait<br>Pfam-B_983 (release 23.0). RebB is one of three proteins necessary for the production of R- bodies, refractile inclusion bodies produced by a small number of bacterial species, essential for the expression of the killing trait of the endosymbiont bacteria that produce them for attack upon the host Paramecium. R-bodies are highly insoluble protein ribbons which coil into cylindrical structures in the cell and the genes for their synthesis and assembly are encoded on a plasmid. One of these three proteins is RebB.. 
+PF11748 Protein of unknown function (DUF3306)<br>Pfam-B_984 (release 23.0). This family of proteobacterial species proteins has no known function.. 
+PF11749 Protein of unknown function (DUF3305)<br>Pfam-B_976 (release 23.0). Several members of this family are annotated as being molybdopterin-guanine dinucleotide biosynthesis protein A; however, this could not be confirmed. The family is found in proteobacteria.. 
+PF11750 Protein of unknown function (DUF3307)<br>Pfam-B_1017 (release 23.0). This family of bacterial proteins has no known function.. 
+PF11751 Protein of unknown function (DUF3308)<br>Pfam-B_993 (release 23.0). Some members of this family of bacterial proteins are annotated as being one of the several TonB-dependent siderophore receptors, but this could not be confirmed.. 
+PF11752 Protein of unknown function (DUF3309)<br>Pfam-B_1113 (release 23.0). This family is conserved in bacteria but its function is not known.. 
+PF11753 Protein of unknwon function (DUF3310)<br>Pfam-B_1078 (release 23.0). This is a family of conserved bacteriophage proteins of unknown function.. 
+PF11754 Velvet factor<br>Pfam-B_963 (release 23.0). The velvet factor is conserved in many fungal species and is found to have gained different roles depending on the organism's need, expanding the conserved role in developmental programmes  . The velvet factor orthologues can be adapted to the fungal-specific life cycle and may be involved in diverse functions such as sclerotia formation and toxin production, as in A. parasiticus  , nutrition-dependent sporulation, as in A. fumigatus  , or the microconidia-to-macroconidia ratio and cell wall formation, as in the heterothallic fungus Fusarium verticilloides [ .. 
+PF11755 Protein of unknown function (DUF3311)<br>Pfam-B_1042 (release 23.0). This is a family of short bacterial proteins of unknown function.. 
+PF11756 Nitrous oxide-stimulated promoter<br>Pfam-B_1030 (release 23.0). The function of ygaB is not known but it is a promoter that is stimulated by the presence of nitrous oxide  . It is regulated by the gene-product of the bacterial nsrR gene.. 
+PF11757 Suppressor of RNA silencing P21-like<br>Pfam-B_1073 (release 23.0). This is a large family of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of the major mechanisms of defence against viruses, and, in response, some viruses have evolved or acquired functions for suppression of RNA silencing. These counter-defencive viral proteins with RNA silencing suppressor (RSS) activity were originally discovered in the members of plant virus genera Potyvirus and Cucumovirus. Each of the conserved blocks of amino acids found in P21-like proteins corresponds to a computer-predicted alpha-helix, with the most C-terminal element being 42 residues long. This suggests conservation of the predominantly alpha-helical secondary structure in the P21-like proteins.. 
+PF11758 Aureocin-like type II bacteriocin<br>This is a small family of type II bacteriocins usually encoded on a plasmid. Characteristically the members are small, cationic, rich in Lys and Try, and bring about a generalised membrane permeabilisation leading to leakage of ions. The family includes aureocin A, lacticins Q and Z, and BhtB as well as an archaeal member.. 
+PF11759 Keratin-associated matrix<br>The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.. 
+PF11760 Cobalamin synthesis G N-terminal<br>Members of this family are involved in cobalamin synthesis.  The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process  . Within the cobalamin synthesis pathway CbiG catalyses the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B  . The N-terminal of the enzyme is conserved in this family, and the C-terminal and the mid-sections are conserved independently in other families, CbiG_C and CbiG_mid, although the distinct function of each region is unclear.. 
+PF11761 Cobalamin biosynthesis central region<br>Members of this family are involved in cobalamin synthesis. The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process  .. 
+PF11762 L-arabinose isomerase C-terminal domain<br>This is a family of L-arabinose isomerases, AraA, EC:5.3.1.4.  These enzymes catalyse the reaction: L-arabinose <=> L-ribulose.  This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into  L-ribulose by the L-arabinose isomerases enzyme  . This is a C-terminal non catalytic domain.. 
+PF11763 Cell-wall adhesin ligand-binding C-terminal<br>Pfam-B_85585 (release 23.0). The DIPSY domain is characterised by the distinctive D*I*PSY motif at the very C-terminus of yeast cell-wall glycoproteins. It appears not to be conserved in any other species, however. In fungi, cell adhesion is required for flocculation, mating and virulence, and is mediated by covalently bound cell wall proteins termed adhesins. Map4, an adhesin required for mating in Schizosaccharomyces pombe, is N-glycosylated and O-glycosylated, and is an endogenous substrate for the mannosyl transferase Oma4p. Map4 has a modular structure with an N-terminal signal peptide, a serine and threonine (S/T)-rich domain that includes nine repeats of 36 amino acids (rich in serine and threonine residues, but lacking glutamines), and a C-terminal DIPSY domain with no glycosyl-phosphatidyl inositol (GPI)-anchor signal. The N-terminal S/T-rich regions, are required for cell wall attachment, but the C-terminal DIPSY domain is required for agglutination and mating in liquid and solid media  .. 
+PF11764 COMPASS (Complex proteins associated with Set1p) component N<br>Pfam-B_7375 (release 23.0). The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans.  The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes  . This domain promotes trimethylation in conjunction with an RRM domain   and is necessary for binding of the Spp1 component of COMPASS into the complex  .. 
+PF11765 Hyphally regulated cell wall protein N-terminal<br>The proteins in this family are all fungal and largely annotated as being hyphally regulated cell wall proteins, and several are listed as the enzyme EC:3.2.1.18. This enzyme is acetylneuraminyl hydrolase or exo-alpha-sialidase, that hydrolyses glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.. 
+PF11766 Cell-wall agglutinin N-terminal ligand-sugar binding <br>This is likely to be the sugar or ligand binding domain of the yeast alpha-agglutinins.. 
+PF11767 Histone lysine methyltransferase SET associated<br>Pfam-B_8752 (release 23.0). SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. A subset of SET domains have been called PR domains. The SET domain consists of two regions known as N-SET and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance.  Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure  . This domain is found in fungi associated with SET and N-SET domains.. 
+PF11768 Protein of unknown function (DUF3312)<br>Pfam-B_5984 (release 23.0). This is a eukaryotic family of uncharacterised proteins. This family shows similarity to WD40 repeat proteins.. 
+PF11769 Protein of unknown function (DUF3313)<br>Pfam-B_1303 (release 23.0). This a bacterial family of proteins which are annotated as putative lipoproteins.. 
+PF11770 GRB2-binding adapter (GAPT)<br>This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells  .  In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation.  It associates with GRB2 constitutively through its proline-rich region  .. 
+PF11771 Protein of unknown function (DUF3314) <br>This small family contains human, mouse and fish members but the function is not known.. 
+PF11772 DNA-directed RNA polymerase subunit beta<br>Pfam-B_4675 (release 23.0). This short 60-residue long bacterial family is the beta subunit of the DNA-directed RNA polymerase, likely to be EC:2.7.7.6. It is membrane-bound and is referred to by the name EpuA.. 
+PF11773 Type II secretory pathway pseudopilin <br>Pfam-B_4690 (release 23.0). The secreton (type II secretion) and type IV pilus biogenesis branches of the general secretory pathway in Gram-negative bacteria share many features that suggest a common evolutionary origin. Five components of the secreton, the pseudopilins, are similar to subunits of type IV pili. Pseudopilin PulG is one of the secreton pseudopilins, and is found to assemble into pilus-like bundles  . PulG interacts with proteins H, I and J within the multi-protein complex as well as blocking extracellular secretion and reducing the amount of PulE protein as well as the amounts of PulL, PulM, PulC and PulD when G is over-expressed  . In Klebsiella the pilus-like structure is composed largely of PulG  .. 
+PF11774 Lsr2 <br>Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes.  It is a functional homologue of the H-NS-like proteins  .  H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression   .. 
+PF11775 Cobalamin biosynthesis protein CobT VWA domain<br>Pfam-B_10956 (release 9.0). This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid  . . 
+PF11776 Domain of unknown function (DUF3315)<br>This is a Proteobacterial family of uncharacterised proteins. Some of the proteins in this family are annotated as being putative membrane proteins.. 
+PF11777 Protein of unknown function (DUF3316)<br>Pfam-B_4718 (release 23.0). This family of bacterial proteins has no known function. Several members are, however, annotated as being putative acyl-CoA synthetase, but this could not be confirmed.. 
+PF11778 Septation initiation<br>Pfam-B_41015 (release 23.0). This family is required for activation of the spg1 GTPase signalling cascade which leads to the initiation of septation and the subsequent termination of mitosis. It may act as a scaffold at the spindle pole body to which other components of the spg1 signalling cascade attach in pombe [1,2,3]. In S.cerevisiae it is both required for the proper formation of the spindle pole body outer plaque and may also connect the outer plaque to the central plaque embedded in the nuclear envelope  .. 
+PF11779 Protein of unknown function (DUF3317)<br>Pfam-B_3618 (release 23.0). This is a short family of proteins conserved from fungi and plants to human. One each of the human and mouse members is annotated as being androgen down-regulated protein expressed in mouse prostate, with a potential signal transduction function, and all appear to be membrane proteins.. 
+PF11780 Protein of unknown function (DUF3318)<br>Pfam-B_1341 (release 23.0). This is a bacterial family of uncharacterised proteins.. 
+PF11781 RNA polymerase I-specific transcription initiation factor Rrn7<br>Pfam-B_4705 (release 23.0). Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [1,2]. . 
+PF11782 Protein of unknown function (DUF3319)<br>Pfam-B_4745 (release 23.0). This is a family of short bacterial proteins, a few of which are annotated as being minor tail protein. Otherwise the function is unknown.. 
+PF11783 Cytochrome c bacterial<br>Pfam-B_4681 (release 23.0). This is a family of long bacterial cytochrome c proteins, found in Proteobacteria and Chlorobi families.. 
+PF11784 Protein of unknown function (DUF3320)<br>Pfam-B_4770 (release 23.0). This family is conserved in Proteobacteria and Chlorobi families. Many members are annotated as being putative DNA helicase-related proteins.. 
+PF11785 Aft1 osmotic stress response (OSM) domain<br>This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The OSM domain has been shown to be involved in the osmotic stress response  .. 
+PF11786 Aft1 HRA domain<br>This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The HRA domain is involved in meiotic recombination.  It has been shown to be necessary and sufficient to activate recombination  .. 
+PF11787 Aft1 HRR domain<br>This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The HRR domain is involved in meiotic recombination.  It has been shown to be necessary and sufficient to repress recombination  .. 
+PF11788 39S mitochondrial ribosomal protein L46 <br>Pfam-B_1897 (release 23.0). This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.. 
+PF11789 Zinc-finger of the MIZ type in Nse subunit<br>Pfam-B_1696 (release 23.0). Nse1 and Nse2 are novel non-SMC subunits of the fission yeast Smc5-6 DNA repair complex. This family is the zinc-finger domain similar to the MIZ type of zinc-finger  .. 
+PF11790 Glycosyl hydrolase catalytic core<br>Pfam-B_1680 (release 23.0), IPR013781. This family is probably a glycosyl hydrolase, and is conserved in fungi and some Proteobacteria. The pombe member is annotated as being from IPR013781.. 
+PF11791 Aconitate B N-terminal domain<br>Pfam-B_2605 (release 10.0). This family represents the N-terminal domain of Aconitase B.. 
+PF11792 Baculoviridae late expression factor 5 C-terminal domain<br>Pfam-B_5141 (release 7.6). This C-terminal domain is likely to be a zinc-binding domain.. 
+PF11793 FANCL C-terminal domain<br>This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.. 
+PF11794 4-hydroxyphenylacetate 3-hydroxylase N terminal<br>Pfam-B_3148 (release 6.5). HpaB Swiss:Q57160 encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli  . HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This family also includes PvcC Swiss:O30372 may play a role in one of the proposed hydroxylation steps of pyoverdine chromophore biosynthesis  . . 
+PF11795 Uncharacterized protein conserved in bacteria N-term (DUF3322)<br>This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the N-terminus.. 
+PF11796 Protein of unknown function N-terminus (DUF3323)<br>Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Beta-proteobacteria).. 
+PF11797 Protein of unknown function C-terminal (DUF3324)<br>Pfam-B_7106 (release 9.0). This family consists of several hypothetical bacterial proteins of unknown function.. 
+PF11798 IMS family HHH motif<br>Pfam-B_1349 (release 2.1). These proteins are involved in UV protection, eg (Swiss:P07375).. 
+PF11799 impB/mucB/samB family C-terminal domain<br>Pfam-B_1349 (release 2.1). These proteins are involved in UV protection (Swiss).. 
+PF11800 Replication protein C C-terminal region<br>Pfam-B_4463 (release 6.6). Replication protein C is involved in the early stages of viral DNA replication.. 
+PF11801 Tom37 C-terminal domain<br>Pfam-B_30563 (release 22.0). The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane  . It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex  .. 
+PF11802 Centromere-associated protein K<br>CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.. 
+PF11803 UDP-glucuronate decarboxylase N-terminal<br>Pfam-B_36254 (release 23.0). The N-terminus of the UDP-glucuronate decarboxylases may be involved in localisation to the perinuclear Golgi membrane.. 
+PF11804 Protein of unknown function (DUF3325)<br>PFAM-B_2004 (release 23.0). This family of short proteins are functionally uncharacterized. This family is restricted to Alpha-, Beta- and Gamma-proteobacteria.. 
+PF11805 Protein of unknown function (DUF3326)<br>PFAM-B_2030 (release 23.0). This protein is functionally uncharacterized. It is about 300-500 amino acids in length.  This family is found in plants and bacteria.. 
+PF11806 Domain of unknown function (DUF3327)<br>PFAM-B_2060 (release 23.0). 
+PF11807 Domain of unknown function (DUF3328)<br>PFAM-B_2062 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in eukaryotes.. 
+PF11808 Domain of unknown function (DUF3329)<br>PFAM-B_2082 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria.. 
+PF11809 Domain of unknown function (DUF3330)<br>PFAM-B_2077 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria.. 
+PF11810 Domain of unknown function (DUF3332)<br>PFAM-B_2104 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria.. 
+PF11811 Domain of unknown function (DUF3331)<br>PFAM-B_2106 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family vary in length from 96 to 160 amino acids.. 
+PF11812 Domain of unknown function (DUF3333)<br>PFAM-B_2108 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria.  This presumed domain is typically between 116 to 159 amino acids in length.. 
+PF11813 Protein of unknown function (DUF3334)<br>PFAM-B_2118 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family are typically between 227 to 238 amino acids in length.. 
+PF11814 Peptidase_C39 like family<br>PFAM-B_2152 (release 23.0). 
+PF11815 Domain of unknown function (DUF3336)<br>PFAM-B_2157 (release 23.0). This family of proteins are functionally uncharacterised. This family is found in bacteria and eukaryotes. This presumed domain is typically between 143 to 227 amino acids in length.. 
+PF11816 Domain of unknown function (DUF3337)<br>PFAM-B_2058 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.. 
+PF11817 Foie gras liver health family 1<br>Pfam-B_4417 (release 23.0). Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease  . Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first  . The C-terminus of this region contains TPR repeats.. 
+PF11818 C-terminal domain of tail specific protease (DUF3340)<br>PFAM-B_2330 (release 23.0). This presumed domain is found at the C-terminus of tail specific proteases. Its function is unknown. This family is found in bacteria and eukaryotes.  This presumed domain is typically between 88 to 187 amino acids in length.. 
+PF11819 Domain of unknown function (DUF3338)<br>PFAM-B_2474 (release 23.0). This family of proteins are functionally uncharacterised. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.. 
+PF11820 Protein of unknown function (DUF3339)<br>PFAM-B_2694 (release 23.0). This family of proteins are functionally uncharacterised. This family is found in eukaryotes. Proteins in this family are about 70 amino acids in length.. 
+PF11821 Protein of unknown function (DUF3341)<br>PFAM-B_2731 (release 23.0). This family of proteins are functionally uncharacterised. This family is found in bacteria. Proteins in this family are about 170 amino acids in length.. 
+PF11822 Domain of unknown function (DUF3342)<br>PFAM-B_2751 (release 23.0). This family of proteins are functionally uncharacterised. This family is found in bacteria. This presumed domain is typically between 170 to 303 amino acids in length. The N-terminal half of this family is a BTB-like domain.. 
+PF11823 Protein of unknown function (DUF3343)<br>PFAM-B_2956 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 78 to 102 amino acids in length.. 
+PF11824 Protein of unknown function (DUF3344)<br>PFAM-B_3041 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 367 to 1857 amino acids in length.. 
+PF11825 DUF3345;<br>Nuclear/hormone receptor activator site AF-1. PFAM-B_3322 (release 23.0). Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription  . One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif  .. 
+PF11826 Protein of unknown function (DUF3346)<br>PFAM-B_3462 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 231 to 659 amino acids in length.. 
+PF11827 Protein of unknown function (DUF3347)<br>PFAM-B_3580 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.. 
+PF11828 Protein of unknown function (DUF3348)<br>PFAM-B_3615 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 244 to 323 amino acids in length.. 
+PF11829 Protein of unknown function (DUF3349)<br>PFAM-B_3716 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.. 
+PF11830 Domain of unknown function (DUF3350)<br>PFAM-B_3789 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 50 to 64 amino acids in length.. 
+PF11831 DUF3351;<br>pre-mRNA splicing factor component. PFAM-B_3985 (release 23.0). This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.. 
+PF11832 Protein of unknown function (DUF3352)<br>PFAM-B_2160 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 538 to 575 amino acids in length.. 
+PF11833 Protein of unknown function (DUF3353)<br>PFAM-B_2231 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 205 to 258 amino acids in length.. 
+PF11834 Domain of unknown function (DUF3354)<br>PFAM-B_2265 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 60 amino acids in length.. 
+PF11835 Domain of unknown function (DUF3355)<br>PFAM-B_2268 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 111 to 177 amino acids in length.. 
+PF11836 Protein of unknown function (DUF3356)<br>PFAM-B_2406 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 104 to 119 amino acids in length.. 
+PF11837 Domain of unknown function (DUF3357)<br>PFAM-B_2464 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 96 to 119 amino acids in length.. 
+PF11838 DUF3358;<br>ERAP1-like C-terminal domain. PFAM-B_2558 (release 23.0). This large domain is composed of 16 alpha helices organized as 8  HEAT-like repeats. This domain forms a concave face that faces  towards the active site of the peptidase.. 
+PF11839 Protein of unknown function (DUF3359)<br>PFAM-B_2625 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.. 
+PF11840 Protein of unknown function (DUF3360)<br>PFAM-B_2754 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 489 to 517 amino acids in length.. 
+PF11841 Domain of unknown function (DUF3361)<br>PFAM-B_2780 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 154 to 168 amino acids in length.. 
+PF11842 Domain of unknown function (DUF3362)<br>PFAM-B_2839 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 117 to 158 amino acids in length.. 
+PF11843 Protein of unknown function (DUF3363)<br>PFAM-B_2310 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 323 to 658 amino acids in length.. 
+PF11844 Domain of unknown function (DUF3364)<br>PFAM-B_2336 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 60 amino acids in length.. 
+PF11845 Protein of unknown function (DUF3365)<br>PFAM-B_2563 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 198 to 657 amino acids in length.. 
+PF11846 Domain of unknown function (DUF3366)<br>PFAM-B_2678 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 200 amino acids in length.. 
+PF11847 Domain of unknown function (DUF3367)<br>PFAM-B_2726 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.. 
+PF11848 Domain of unknown function (DUF3368)<br>PFAM-B_2745 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is about 50 amino acids in length.. 
+PF11849 Domain of unknown function (DUF3369)<br>PFAM-B_2927 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 170 amino acids in length. The domain appears to be related to the GAF domain.. 
+PF11850 Protein of unknown function (DUF3370)<br>PFAM-B_3037 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 452 to 532 amino acids in length.. 
+PF11851 Domain of unknown function (DUF3371)<br>PFAM-B_3115 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.. 
+PF11852 Domain of unknown function (DUF3372)<br>PFAM-B_3259 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This presumed domain is about 170 amino acids in length.. 
+PF11853 Protein of unknown function (DUF3373)<br>PFAM-B_3442 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 472 to 574 amino acids in length.. 
+PF11854 Protein of unknown function (DUF3374)<br>PFAM-B_3548 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 665 to 712 amino acids in length.. 
+PF11855 Protein of unknown function (DUF3375)<br>PFAM-B_3589 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.. 
+PF11856 Protein of unknown function (DUF3376)<br>PFAM-B_3667 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 770 to 1142 amino acids in length.. 
+PF11857 Domain of unknown function (DUF3377)<br>PFAM-B_3829 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 70 amino acids in length.. 
+PF11858 Domain of unknown function (DUF3378)<br>PFAM-B_3989 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 80 amino acids in length.. 
+PF11859 Protein of unknown function (DUF3379)<br>PFAM-B_2469 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 234 to 251 amino acids in length.. 
+PF11860 Protein of unknown function (DUF3380)<br>PFAM-B_2757 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 194 to 284 amino acids in length. This protein is found associated with Pfam:PF01471.. 
+PF11861 Domain of unknown function (DUF3381)<br>PFAM-B_2792 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 156 to 174 amino acids in length. This domain is found associated with Pfam:PF07780, Pfam:PF01728.. 
+PF11862 Domain of unknown function (DUF3382)<br>PFAM-B_2882 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 100 amino acids in length. This domain is found associated with Pfam:PF02653.. 
+PF11863 Protein of unknown function (DUF3383)<br>PFAM-B_3017 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 356 to 501 amino acids in length.. 
+PF11864 Domain of unknown function (DUF3384)<br>PFAM-B_3114 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with Pfam:PF02145.. 
+PF11865 Domain of unknown function (DUF3385)<br>PFAM-B_3188 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is typically between 160 to 172 amino acids in length.  This domain is found associated with Pfam:PF00454, Pfam:PF02260, Pfam:PF02985, Pfam:PF02259 and Pfam:PF08771.. 
+PF11866 Protein of unknown function (DUF3386)<br>PFAM-B_3390 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 220 amino acids in length.. 
+PF11867 Domain of unknown function (DUF3387)<br>PFAM-B_3465 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 255 to 340 amino acids in length. This domain is found associated with Pfam:PF04851, Pfam:PF04313.. 
+PF11868 Protein of unknown function (DUF3388)<br>PFAM-B_3650 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 261 to 275 amino acids in length. This protein is found associated with Pfam:PF01842.. 
+PF11869 Protein of unknown function (DUF3389)<br>PFAM-B_3739 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.. 
+PF11870 Domain of unknown function (DUF3390)<br>PFAM-B_3832 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 90 amino acids in length. This domain is found associated with Pfam:PF02589.. 
+PF11871 Domain of unknown function (DUF3391)<br>PFAM-B_2190 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is typically between 122 to 139 amino acids in length. This domain is found associated with Pfam:PF01966.. 
+PF11872 Protein of unknown function (DUF3392)<br>PFAM-B_2322 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.. 
+PF11873 Domain of unknown function (DUF3393)<br>PFAM-B_2361 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is typically between 188 to 206 amino acids in length. This domain is found associated with Pfam:PF01464.. 
+PF11874 Domain of unknown function (DUF3394)<br>PFAM-B_2758 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 190 amino acids in length. This domain is found associated with Pfam:PF06808.. 
+PF11875 Domain of unknown function (DUF3395)<br>PFAM-B_2767 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 147 to 176 amino acids in length. This domain is found associated with Pfam:PF00226.. 
+PF11876 Protein of unknown function (DUF3396)<br>PFAM-B_2995 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 302 to 382 amino acids in length.. 
+PF11877 Protein of unknown function (DUF3397)<br>PFAM-B_3446 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 114 to 128 amino acids in length.. 
+PF11878 Domain of unknown function (DUF3398)<br>PFAM-B_3712 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length.. 
+PF11879 Domain of unknown function (DUF3399)<br>PFAM-B_3857 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 100 amino acids in length.  This domain is found associated with Pfam:PF02214, Pfam:PF00520.. 
+PF11880 Domain of unknown function (DUF3400)<br>PFAM-B_3996 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 50 amino acids in length.  This domain is found associated with Pfam:PF02754, Pfam:PF02913, Pfam:PF01565.. 
+PF11881 Domain of unknown function (DUF3401)<br>PFAM-B_2478 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 231 to 250 amino acids in length. This domain is found associated with Pfam:PF02145, Pfam:PF00595.. 
+PF11882 Domain of unknown function (DUF3402)<br>PFAM-B_2702 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 350 to 473 amino acids in length. This domain is found associated with Pfam:PF07923.. 
+PF11883 Domain of unknown function (DUF3403)<br>PFAM-B_2739 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 50 amino acids in length.  This domain is found associated with Pfam:PF00069, Pfam:PF08276, Pfam:PF00954, Pfam:PF01453.. 
+PF11884 Domain of unknown function (DUF3404)<br>PFAM-B_2879 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 260 amino acids in length. This domain is found associated with Pfam:PF02518, Pfam:PF00512.. 
+PF11885 Protein of unknown function (DUF3405)<br>PFAM-B_3057 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 636 to 810 amino acids in length.. 
+PF11886 Domain of unknown function (DUF3406)<br>PFAM-B_3286 (release 23.0). This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 270 amino acids in length. This domain is found associated with Pfam:PF04548.. 
+PF11887 Protein of unknown function (DUF3407)<br>PFAM-B_3559 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 360 to 454 amino acids in length. This protein is found associated with Pfam:PF02470.. 
+PF11888 Protein of unknown function (DUF3408)<br>PFAM-B_3594 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 128 to 160 amino acids in length.. 
+PF11889 Domain of unknown function (DUF3409)<br>PFAM-B_3824 (release 23.0). This domain is functionally uncharacterised. This domain is found in viruses.  This presumed domain is about 60 amino acids in length.  This domain is found associated with Pfam:PF00271, Pfam:PF05550, Pfam:PF05578.. 
+PF11890 Domain of unknown function (DUF3410)<br>PFAM-B_1956 (release 23.0). This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 90 amino acids in length. This domain is found associated with Pfam:PF02826, Pfam:PF00389. This domain has a conserved RRE sequence motif.. 
+PF11891 Domain of unknown function (DUF3411)<br>PFAM-B_1986 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 168 to 186 amino acids in length. This domain has a conserved RYQ sequence motif.. 
+PF11892 Domain of unknown function (DUF3412)<br>PFAM-B_1106 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain is found associated with Pfam:PF03641.. 
+PF11893 Domain of unknown function (DUF3413)<br>PFAM-B_1403 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 250 amino acids in length. This domain is found associated with Pfam:PF00884.. 
+PF11894 Protein of unknown function (DUF3414)<br>PFAM-B_1638 (release 23.0). This family of proteins are functionally uncharacterised. The family is found in eukaryotes and has a conserved LLG sequence motif.. 
+PF11895 Domain of unknown function (DUF3415)<br>PFAM-B_1962 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length. This domain is found associated with Pfam:PF00141.. 
+PF11896 Domain of unknown function (DUF3416)<br>PFAM-B_601 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 190 amino acids in length. This domain is found associated with Pfam:PF00128.. 
+PF11897 Protein of unknown function (DUF3417)<br>PFAM-B_724 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 145 to 860 amino acids in length. This protein is found associated with Pfam:PF00343. This protein has a conserved AYF sequence motif.. 
+PF11898 Domain of unknown function (DUF3418)<br>PFAM-B_1028 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with Pfam:PF07717, Pfam:PF00271, Pfam:PF04408.. 
+PF11899 Protein of unknown function (DUF3419)<br>PFAM-B_1329 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 398 to 802 amino acids in length.. 
+PF11900 Domain of unknown function (DUF3420)<br>PFAM-B_1362 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00023.. 
+PF11901 Protein of unknown function (DUF3421)<br>PFAM-B_1420 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 119 to 296 amino acids in length.. 
+PF11902 Protein of unknown function (DUF3422)<br>PFAM-B_513 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 426 to 444 amino acids in length.. 
+PF11903 Protein of unknown function (DUF3423)<br>PFAM-B_670 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 73 to 118 amino acids in length. This protein appears to be related to ribbon-helix-helix DNA-binding domains, suggesting these proteins may also bind DNA.. 
+PF11904 DUF3424;<br>PFAM-B_942 (release 23.0). This domain, and the associated ANK family repeat Pfam:PF00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.. 
+PF11905 Domain of unknown function (DUF3425)<br>PFAM-B_1128 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 120 to 143 amino acids in length.. 
+PF11906 Protein of unknown function (DUF3426)<br>PFAM-B_1212 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 262 to 463 amino acids in length.. 
+PF11907 Domain of unknown function (DUF3427)<br>PFAM-B_1236 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 243 to 275 amino acids in length. This domain is found associated with Pfam:PF04851, Pfam:PF00271.. 
+PF11909 NADH-quinone oxidoreductase cyanobacterial subunit N<br>The proton-pumping NADH:ubiquinone oxidoreductase catalyzes the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides. Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 subcomplexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit  . The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms  .. 
+PF11910 Cyanobacterial and plant NDH-1 subunit O<br>The proton-pumping NADH:ubiquinone oxidoreductase catalyzes the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides.  Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 subcomplexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1, 2]. The three nuclear-encoded subunits NdhM,NdhN and NdhO are vital for the functional integrity of the plastidial complex  .. 
+PF11911 Protein of unknown function (DUF3429)<br>PFAM-B_1072 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 147 to 245 amino acids in length.. 
+PF11912 Protein of unknown function (DUF3430)<br>PFAM-B_1305 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 209 to 265 amino acids in length.. 
+PF11913 Protein of unknown function (DUF3431)<br>PFAM-B_1346 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 291 to 390 amino acids in length. This protein has a conserved NLRC sequence motif.. 
+PF11914 Domain of unknown function (DUF3432)<br>PFAM-B_1326 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with Pfam:PF00096. This domain has two conserved sequence motifs: YPSPV and PSP.. 
+PF11915 Protein of unknown function (DUF3433)<br>PFAM-B_1502 (release 23.0). This is a family of functionally uncharacterised proteins. The family is found in eukaryotes, and represents the conserved central region of the member proteins.. 
+PF11916 DUF3434;<br>Vacuolar protein 14 C-terminal Fig4p binding. PFAM-B_1661 (release 23.0). Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.. 
+PF11917 Protein of unknown function (DUF3435)<br>PFAM-B_1788 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 435 to 791 amino acids in length. This family is related to Pfam:PF00589 suggesting it may be an integrase enzyme.. 
+PF11918 Domain of unknown function (DUF3436)<br>PFAM-B_18 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF03572. This domain has two conserved sequence motifs: DPRL and SYEP.. 
+PF11919 Domain of unknown function (DUF3437)<br>PFAM-B_1910 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 142 to 163 amino acids in length.. 
+PF11920 Protein of unknown function (DUF3438)<br>PFAM-B_1942 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 276 to 307 amino acids in length.. 
+PF11921 Domain of unknown function (DUF3439)<br>PFAM-B_1105 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with Pfam:PF01462, Pfam:PF00560.. 
+PF11922 Domain of unknown function (DUF3440)<br>PFAM-B_1674 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 53 to 190 amino acids in length. This domain is found associated with Pfam:PF01507. This domain has a conserved KND sequence motif.. 
+PF11923 Domain of unknown function (DUF3441)<br>PFAM-B_1795 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in archaea and eukaryotes. This domain is typically between 104 to 119 amino acids in length. This domain is found associated with Pfam:PF05833, Pfam:PF05670. This domain has two conserved residues (P and G) that may be functionally important.. 
+PF11924 Protein of unknown function (DUF3442)<br>PFAM-B_890 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 334 to 948 amino acids in length.. 
+PF11925 Protein of unknown function (DUF3443)<br>PFAM-B_1634 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 400 to 434 amino acids in length. This protein has two conserved sequence motifs: NPV and DNNG.. 
+PF11926 Domain of unknown function (DUF3444)<br>PFAM-B_1267 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 210 amino acids in length. This domain is found associated with Pfam:PF00226. This domain has two conserved sequence motifs: FSH and FSH.. 
+PF11927 Protein of unknown function (DUF3445)<br>PFAM-B_501 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 264 to 418 amino acids in length. This protein has a conserved RLP sequence motif. This protein has two completely conserved R residues that may be functionally important.. 
+PF11928 Domain of unknown function (DUF3446)<br>PFAM-B_833 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 80 to 99 amino acids in length. This domain is found associated with Pfam:PF00096. This domain has a single completely conserved residue P that may be functionally important.. 
+PF11929 Domain of unknown function (DUF3447)<br>PFAM-B_10 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length.  This domain is found associated with Pfam:PF00023. This domain has a conserved SHN sequence motif. It seems likely that this region represents divergent Ankyrin repeats.. 
+PF11931 Domain of unknown function (DUF3449)<br>PFAM-B_769 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 181 to 207 amino acids in length. This domain has two conserved sequence motifs: PIP and CEICG. The domain carries a zinc-finger domain of the C2H2-type.. 
+PF11932 Protein of unknown function (DUF3450)<br>PFAM-B_773 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 260 amino acids in length.. 
+PF11933 Domain of unknown function (DUF3451)<br>PFAM-B_877 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 199 to 238 amino acids in length. This domain is found associated with Pfam:PF06512, Pfam:PF00520. This domain has a conserved ADD sequence motif.. 
+PF11934 Domain of unknown function (DUF3452)<br>PFAM-B_1048 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with Pfam:PF01858, Pfam:PF01857. This domain has a single completely conserved residue W that may be functionally important.. 
+PF11935 Domain of unknown function (DUF3453)<br>PFAM-B_1335 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 239 to 261 amino acids in length.. 
+PF11936 Domain of unknown function (DUF3454)<br>PFAM-B_1847 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 60 amino acids in length. This domain is found associated with Pfam:PF00066, Pfam:PF00008, Pfam:PF06816, Pfam:PF07684, Pfam:PF00023.. 
+PF11937 Protein of unknown function (DUF3455)<br>PFAM-B_1386 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.. 
+PF11938 TLR4 regulator and MIR-interacting MSAP<br>PFAM-B_1799 (release 23.0). This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection  . PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there   . TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria.\.    This family has also been described as a SAP-like MIR-interacting protein family.. 
+PF11939 Protein of unknown function (DUF3457)<br>PFAM-B_1822 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 162 to 197 amino acids in length. This protein has a conserved CSL sequence motif.. 
+PF11940 Domain of unknown function (DUF3458)<br>PFAM-B_160 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 402 to 419 amino acids in length. This domain is found associated with Pfam:PF01433. This domain has a conserved FSAPV sequence motif.. 
+PF11941 Domain of unknown function (DUF3459)<br>PFAM-B_897 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 110 amino acids in length. This domain is found associated with Pfam:PF00128, Pfam:PF02922.. 
+PF11942 Spt5 transcription elongation factor, acidic N-terminal<br>This is the very acidic N-terminal region of the early transcription elongation factor Spt5  . The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4  .. 
+PF11943 Protein of unknown function (DUF3460)<br>PFAM-B_2362 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 70 amino acids in length. This protein has a conserved WDK sequence motif.. 
+PF11944 Protein of unknown function (DUF3461)<br>PFAM-B_2125 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length. This protein has two conserved sequence motifs: KFK and HLE.. 
+PF11945 DUF3462;<br>WAHD domain of WASH complex. PFAM-B_2071 (release 23.0). This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see Pfam:PF04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.. 
+PF11946 Domain of unknown function (DUF3463)<br>PFAM-B_2277 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 140 amino acids in length. This domain is found associated with Pfam:PF04055. This domain has two conserved sequence motifs: CTPWG and PCYL, plus a highly conserved CxxCxxHC motif.. 
+PF11947 Protein of unknown function (DUF3464)<br>PFAM-B_2676 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 137 to 196 amino acids in length.. 
+PF11948 Protein of unknown function (DUF3465)<br>PFAM-B_2827 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 131 to 151 amino acids in length. This protein has a conserved HWTH sequence motif.. 
+PF11949 Protein of unknown function (DUF3466)<br>PFAM-B_2541 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 564 to 612 amino acids in length.. 
+PF11950 Protein of unknown function (DUF3467)<br>PFAM-B_2299 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and viruses. Proteins in this family are typically between 101 to 118 amino acids in length.. 
+PF11951 DUF3468;<br>Fungal specific transcription factor domain. PFAM-B_2291 (release 23.0). This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with Pfam:PF00172.. 
+PF11952 Protein of unknown function (DUF3469)<br>PFAM-B_2159 (release 23.0). This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 108 to 439 amino acids in length.. 
+PF11953 Domain of unknown function (DUF3470)<br>PFAM-B_2503 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00037. This domain has a single completely conserved residue N that may be functionally important.. 
+PF11954 Domain of unknown function (DUF3471)<br>PFAM-B_2961 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 98 to 114 amino acids in length. This domain is found associated with Pfam:PF00144.. 
+PF11955 Plant organelle RNA recognition domain<br>Moxon SJ, Barkan A, Coggill P. Pfam-B_1780 (release 8.0). This family, which was previously known as DUF860, has been shown to be a component of group II intron ribonucleoprotein particles in maize chloroplasts. The domain is required for the splicing of the introns with which it associates, and promotes splicing in the context of a heterodimer with the RNase III-domain protein RNC1. All of the members are predicted to localise to mitochondria or chloroplasts  . It seems likely that most PORR proteins function in organellar RNA metabolism  .. 
+PF11956 Ankyrin-G binding motif of KCNQ2-3<br>Pfam-B_10256 (release 23.0). Interactions with ankyrin-G are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system  . This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3  , that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3  . KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2  . Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3)  .. 
+PF11957 THO complex subunit 1 transcription elongation factor<br>Pfam-B_2059 (release 23.0). The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1  . The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm [2,3].. 
+PF11958 Domain of unknown function (DUF3472)<br>PFAM-B_2598 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria, eukaryotes and viruses. This domain is typically between 174 to 190 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.. 
+PF11959 Domain of unknown function (DUF3473)<br>PFAM-B_3065 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 130 amino acids in length. This domain is found associated with Pfam:PF01522. This domain has two completely conserved residues (P and H) that may be functionally important.. 
+PF11960 Domain of unknown function (DUF3474)<br>PFAM-B_3095 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 126 to 140 amino acids in length. This domain is found associated with Pfam:PF00487.. 
+PF11961 Domain of unknown function (DUF3475)<br>PFAM-B_3098 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 60 amino acids in length.  This domain is found associated with Pfam:PF05003.. 
+PF11962 DUF3476;<br>Peptidase_G2, IMC autoproteolytic cleavage domain. PFAM-B_3119 (release 23.0). This domain is found at the very C-terminus of bacteriophage parallel beta-helical tailspike proteins. It carries the enzymic residues that induce autoproteolytic cleavage to bring about maturation of the folding process of the helix in a chaperone-like manner. The domain thus mediates the assembly of a large tailspike protein and then releases itself after maturation. These C-terminal regions that autoproteolytically release themselves after maturation are exchangeable between functionally unrelated N-terminal proteins and have been identified in a number of bacteriophage tailspike proteins  .. 
+PF11963 Protein of unknown function (DUF3477)<br>PFAM-B_3147 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in viruses. Proteins in this family are typically between 246 to 7162 amino acids in length. This protein is found associated with Pfam:PF08716, Pfam:PF01661, Pfam:PF05409, Pfam:PF08717, Pfam:PF01831, Pfam:PF08715, Pfam:PF08710.. 
+PF11964 DUF3478;<br>PFAM-B_640 (release 23.0). These proteins adopt an alpha/beta SpoIIAA-like fold, similar to that found in STAT (Pfam:PF01740). They adopt open and closed conformations arising from different arrangements of their alpha-2 and alpha-3 helices. They may be membrane associated and may function as carriers of non-polar compounds  .. 
+PF11965 Domain of unknown function (DUF3479)<br>PFAM-B_1065 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF02514.. 
+PF11966 Fibronectin-binding repeat<br>Pfam-B_5998 (release 23.0). Streptococcal surface repeat domain - SSURE - is a protein fragment found to bind to extracellular matrix protein fibronectin but not to collagen or submaxillary mucin in Streptococci. Anti-SSURE antibodies recognised the corresponding protein on the surface of streptococcal cells. The full-length proteins are thus fibronectin-binding surface adhesins.. 
+PF11967 Recombination protein O N terminal<br>Recombination protein O (RecO) is involved in DNA repair and Pfam:PF00470 pathway recombination.  This domain forms a beta barrel structure.. 
+PF11968 Putative methyltransferase (DUF3321)<br>Pfam-B_6141 (release 23.0). This family is broadly conserved, being found in fungi, plants, arthropods and up to primates. it may be a methyltransferase.. 
+PF11969 Scavenger mRNA decapping enzyme C-term binding<br>Pfam-B_9894 (release 8.0). This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.. 
+PF11970 G protein-coupled glucose receptor regulating Gpa2 C-term<br>Pfam-B_11657 (release 23.0). Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail  . This family is the conserved C-terminal domain of the member proteins.. 
+PF11971 CAMSAP CH domain<br>This domain is the N-terminal CH domain from the CAMSAP proteins.i. 
+PF11972 HTH DNA binding domain<br>Pfam-B_8688 (release 14.0). This is a helix-turn-helix DNA binding domain.. 
+PF11973 NQRA C-terminal domain<br>Pfam-B_3622 (release 8.0). This family consists of the C-terminal domain of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins.  The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration  .. 
+PF11974 Alpha-2-macroglobulin MG1 domain<br>This is the N-terminal MG1 domain from alpha-2-macroglobulin  .. 
+PF11975 Family 4 glycosyl hydrolase C-terminal domain<br>
+PF11976 Ubiquitin-2 like Rad60 SUMO-like<br>Wood V, Chahwan C, Coggill P. The small ubiquitin-related modifier SUMO-1 is a Ub/Ubl family member, and although SUMO-1 shares structural similarity to Ub, SUMO's cellular functions remain distinct insomuch as SUMO modification alters protein function through changes in activity, cellular localisation, or by protecting substrates from ubiquitination  . Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). Despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9)), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. Structural analysis of PDB:2uyz reveals a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating SUMOylation  . The Rad60 branch of this family is also known as RENi (Rad60-Esc2-Nip45), and biologically it should be two distinct families SUMO and RENi (Rad60-Esc2-Nip45).. 
+PF11977 Zc3h12a-like Ribonuclease NYN domain<br>This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes  . It has been suggested that this domain belongs to the PIN domain superfamily  . This domain has also been identified as part  of the NYN domain family  .. 
+PF11978 Shoulder domain<br>This domain is found in the Major Vault Protein and has been called the shoulder domain  . This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.. 
+PF11979 Domain of unknown function (DUF3480)<br>PFAM-B_2031 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 350 to 362 amino acids in length. This domain is found associated with Pfam:PF01363.. 
+PF11980 Domain of unknown function (DUF3481)<br>Pfam-B_2819 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length.  This domain is found associated with Pfam:PF00754, Pfam:PF00431, Pfam:PF00629. This domain has two completely conserved residues (Y and E) that may be functionally important.. 
+PF11981 Domain of unknown function (DUF3482)<br>PFAM-B_3168 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 289 to 301 amino acids in length. This domain is found associated with Pfam:PF01926. THe central region of these proteins contains a hydrophobic region that is similar to Pfam:PF05433.. 
+PF11982 Domain of unknown function (DUF3483)<br>PFAM-B_3204 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 230 amino acids in length. This domain is found associated with Pfam:PF02754.. 
+PF11983 Domain of unknown function (DUF3484)<br>PFAM-B_3216 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 65 to 81 amino acids in length. This domain is found associated with Pfam:PF02491.. 
+PF11984 Protein of unknown function (DUF3485)<br>PFAM-B_3236 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 223 to 526 amino acids in length. This protein is found associated with Pfam:PF09721.. 
+PF11985 Protein of unknown function (DUF3486)<br>PFAM-B_3271 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are about 190 amino acids in length.. 
+PF11986 Influenza A Proapoptotic protein<br>PB1-F2 is a protein found in almost all known strains of Influenza A virus - a negative sense ssRNA Orthomyxovirus  . It originates from translation of the viral polymerase gene in an alternative reading frame  . PB1-F2 consists of two independent structural domains, two closely neighboring short helices at the N terminus, and an extended C-terminal helix  .  Although the protein has originally been described to induce apoptosis, it has now been shown that PB1-F2 more likely acts as an apoptosis promoter in concert with other apoptosis-inducing agents  . PB1-F2 promotes apoptosis by localising to the mitochondria where it destabilises the membrane. This will cause release of cytochrome C which activates the caspase cascade of apoptosis through the endogenous pathway  . In this way it acts like the Bcl-2 protein family which are physiological apoptotic regulators in cells  .. 
+PF11987 Translation-initiation factor 2<br>IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes  , Bacteria   and Archaea  ). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits  . Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyses the hydrolysis of GTP following initiation-complex formation  .. 
+PF11988 Retrograde transport protein Dsl1 N terminal<br>Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum  . It is localised to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles  . It is comprised primarily of alpha helical bundles  . It complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein  .  A central disorganised region between the N and C termini of Dsl1 contains binding sites for coatomer  . The C terminus of Dsl1 contains a binding site to the Sec39 subunit of the Dsl1p complex  .. 
+PF11989 Retrograde transport protein Dsl1 C terminal<br>Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum  . It is localised to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles  . Binding sites for coatomer are found on a disorganised region between the C and N termini of Dsl1  . The C terminal domain is involved in binding to the Sec39 subunit of the Dsl1p complex  . The N terminal complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein  .. 
+PF11990 Protein of unknown function (DUF3487)<br>PFAM-B_2242 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 121 to 136 amino acids in length. This protein has a conserved RLN sequence motif.. 
+PF11991 Tryptophan dimethylallyltransferase<br>PFAM-B_2054 (release 23.0). This family of proteins represents tryptophan dimethylallyltransferase (EC:2.5.1.34), which catalyses the first step of ergot alkaloid biosynthesis  . Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 390 to 465 amino acids in length.. 
+PF11992 Domain of unknown function (DUF3488)<br>PFAM-B_3123 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 323 to 339 amino acids in length. This domain is found associated with Pfam:PF01841. This domain has a conserved PLW sequence motif. This domain contains 6 transmembrane helices.. 
+PF11993 Ribosomal S4P (gammaproteobacterial)<br>PFAM-B_3290 (release 23.0). This family of proteins are ribosomal SSU S4 p proteins. This protein is found in gamma-proteobacteria. Proteins in this family are typically between 162 to 178 amino acids in length.. 
+PF11994 Protein of unknown function (DUF3489)<br>PFAM-B_3545 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 84 to 211 amino acids in length. This protein has a single completely conserved residue W that may be functionally important.. 
+PF11995 Domain of unknown function (DUF3490)<br>PFAM-B_3558 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF00225. This domain is found associated with Pfam:PF00225. This domain has two conserved sequence motifs: EVE and ESA.. 
+PF11996 Protein of unknown function (DUF3491)<br>PFAM-B_3393 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 286 to 3225 amino acids in length. This protein is found associated with Pfam:PF04488. This protein is found associated with Pfam:PF04488.. 
+PF11997 Domain of unknown function (DUF3492)<br>PFAM-B_2107 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 259 to 282 amino acids in length. This domain is found associated with Pfam:PF00534. This domain has two conserved sequence motifs: GGVS and EHGIY.. 
+PF11998 Protein of unknown function (DUF3493)<br>PFAM-B_3788 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 79 to 331 amino acids in length.. 
+PF11999 Protein of unknown function (DUF3494)<br>PFAM-B_3080 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 243 to 678 amino acids in length. This protein has a single completely conserved residue G that may be functionally important.. 
+PF12000 DUF3495;<br>Gkycosyl transferase family 4 group. PFAM-B_3335 (release 23.0). This domain is found associated with Pfam:PF00534.. 
+PF12001 Domain of unknown function (DUF3496)<br>PFAM-B_3407 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 110 amino acids in length.. 
+PF12002 MgsA AAA+ ATPase C terminal<br>The MgsA protein possesses DNA-dependent ATPase and ssDNA annealing activities  . MgsA contributes to the recovery of stalled replication forks and therefore prevents genomic instability caused by aberrant DNA replication  . Additionally, MgsA may play a role in chromosomal segregation  . This is consistent with a report that MgsA co-localises with the replisome and affects chromosome segregation  .  This domain represents the C terminal region of MgsA.. 
+PF12003 Domain of unknown function (DUF3497)<br>PFAM-B_3419 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 213 to 257 amino acids in length. This domain is found associated with Pfam:PF02793, Pfam:PF00002, Pfam:PF01825. This domain has a single completely conserved residue W that may be functionally important.. 
+PF12004 Domain of unknown function (DUF3498)<br>PFAM-B_3438 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 433 to 538 amino acids in length. This domain is found associated with Pfam:PF00616, Pfam:PF00168. This domain has two conserved sequence motifs: DLQ and PLSFQNP.. 
+PF12005 Protein of unknown function (DUF3499)<br>PFAM-B_3439 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.. 
+PF12006 Protein of unknown function (DUF3500)<br>PFAM-B_3479 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 335 to 438 amino acids in length. This protein has a conserved GHH sequence motif. This protein has two completely conserved G residues that may be functionally important.. 
+PF12007 Protein of unknown function (DUF3501)<br>PFAM-B_3488 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are about 200 amino acids in length. The structure of protein Swiss:Q63J81 from B. pseudomallei has been solved. This protein contains two domains, domain I (1:31, 46:81) is a helical domain, domain II (32:45,82-193) is a mainly beta protein with a beta barrel. According to crystal contacts the proteins probably functions as a dimer. The gene neighbourhood analysis suggests that this protein may be functionally related to rubrerythrin and ferredoxin. The wedge surface between the two domains might be functionally important. The fold of this protein could best be described as a circularly permuted C2-like fold (details derived from TOPSAN).. 
+PF12008 Type I restriction and modification enzyme - subunit R C terminal<br>This enzyme has been characterised and shown to belong to a new family of the type I class of restriction and modification enzymes. This family is involved in bacterial defence by making double strand breaks in specific double stranded DNA sequences, e.g. that of invading bacteriophages. EcoR124 is made up of three subunits, HsdR, HsdS and HsdM. The R subunit has ATPase and restriction endonuclease activity. This domain is the C terminal of the R subunit  .. 
+PF12009 Telomerase ribonucleoprotein complex - RNA binding domain<br>Telomeres in most organisms are comprised of tandem simple sequence repeats  . The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition  . One major influence on telomere length is the enzyme telomerase  . It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme  . The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets  . How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA  .. 
+PF12010 Domain of unknown function (DUF3502)<br>PFAM-B_3448 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with Pfam:PF01547.. 
+PF12011 Domain of unknown function (DUF3503)<br>PFAM-B_2686 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in viruses. This domain is about 170 amino acids in length. This domain is found associated with Pfam:PF00271.. 
+PF12012 Domain of unknown function (DUF3504)<br>PFAM-B_2196 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.. 
+PF12013 Protein of unknown function (DUF3505)<br>PFAM-B_2856 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 247 to 1018 amino acids in length. This region contains two segments that are likely to be C2H2 zinc binding domains.. 
+PF12014 Domain of unknown function (DUF3506)<br>PFAM-B_3293 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 131 to 148 amino acids in length. This domain has a conserved KLTGD sequence motif.. 
+PF12015 Domain of unknown function (DUF3507)<br>PFAM-B_3482 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 180 amino acids in length. This domain has a conserved ENL sequence motif.. 
+PF12016 Stonin 2<br>Stonin 2 is involved in clathrin mediated endocytosis  . It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs)  . In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling  .. 
+PF12017 Transposase_37;<br>PFAM-B_3357 (release 23.0). Protein in this family are transposases found in insects. This region is about 230 amino acids in length and is found associated with Pfam:PF05485.. 
+PF12018 Domain of unknown function (DUF3508)<br>PFAM-B_3527 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 280 amino acids in length.  This domain has two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704.. 
+PF12019 Type II transport protein GspH<br>GspH is involved in bacterial type II export systems  . Like all pilins, GspH has an N terminus alpha helix  . This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands  . GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins)  .  The function and localisation of minor pseudo-pilins are still to be fully unraveled  . It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS  .. 
+PF12020 TAFA family<br>PFAM-B_3899 (release 23.0). This family of secreted proteins are brain specific and thought to be chemokines  .  These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.. 
+PF12021 Protein of unknown function (DUF3509)<br>PFAM-B_2180 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 92 to 110 amino acids in length. This protein has two completely conserved residues (G and R) that may be functionally important.. 
+PF12022 Domain of unknown function (DUF3510)<br>PFAM-B_2857 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 130 amino acids in length. This domain is found associated with Pfam:PF06148.. 
+PF12023 Domain of unknown function (DUF3511)<br>PFAM-B_3314 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain has two completely conserved residues (Y and K) that may be functionally important.. 
+PF12024 Domain of unknown function (DUF3512)<br>PFAM-B_3525 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with Pfam:PF00439.. 
+PF12025 Phage protein C<br>PFAM-B_3530 (release 23.0). This family of phage proteins is functionally uncharacterised. Proteins in this family are typically between 68 to 86 amino acids in length.. 
+PF12026 Domain of unknown function (DUF3513)<br>PFAM-B_3541 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 192 to 218 amino acids in length. This domain is found associated with Pfam:PF00018, Pfam:PF08824. This domain has a conserved QPP sequence motif.. 
+PF12027 Protein of unknown function (DUF3514)<br>PFAM-B_3570 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 368 to 823 amino acids in length.. 
+PF12028 Protein of unknown function (DUF3515)<br>PFAM-B_3590 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.. 
+PF12029 Domain of unknown function (DUF3516)<br>PFAM-B_3601 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with Pfam:PF00270, Pfam:PF00271.. 
+PF12030 Domain of unknown function (DUF3517)<br>PFAM-B_3933 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 340 amino acids in length. This domain is found associated with Pfam:PF00443.. 
+PF12031 Domain of unknown function (DUF3518)<br>PFAM-B_3830 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 260 amino acids in length. This domain is found associated with Pfam:PF01388.. 
+PF12032 Regulatory CLIP domain of proteinases<br>CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively.    . 
+PF12033 Protein of unknown function (DUF3519)<br>PFAM-B_2444 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 117 to 1154 amino acids in length. This protein has a single completely conserved residue Q that may be functionally important.. 
+PF12034 Domain of unknown function (DUF3520)<br>PFAM-B_3604 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 180 amino acids in length. This domain is found associated with Pfam:PF00092.. 
+PF12035 Protein of unknown function (DUF3521)<br>PFAM-B_3612 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 42 to 74 amino acids in length.. 
+PF12036 Protein of unknown function (DUF3522)<br>PFAM-B_3665 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length.. 
+PF12037 Domain of unknown function (DUF3523)<br>PFAM-B_3746 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 257 to 277 amino acids in length. This domain is found associated with Pfam:PF00004. This domain has a conserved LER sequence motif.. 
+PF12038 Domain of unknown function (DUF3524)<br>PFAM-B_3749 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is about 170 amino acids in length. This domain is found associated with Pfam:PF00534. This domain has two conserved sequence motifs: HENQ and FNS. This domain has a single completely conserved residue S that may be functionally important.. 
+PF12039 Protein of unknown function (DUF3525)<br>PFAM-B_3833 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in viruses. Proteins in this family are about 360 amino acids in length.. 
+PF12040 Domain of unknown function (DUF3526)<br>PFAM-B_3851 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 149 to 170 amino acids in length. This domain has a single completely conserved residue P that may be functionally important.. 
+PF12041 Transcriptional regulator DELLA protein N terminal<br>Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.  . 
+PF12042 Tubuliform egg casing silk strands structural domain<br>Spiders use fibroins to make silk strands. This family includes tubuliform silk fibroins which are used to protect egg cases. This domain is a structural domain which is found in repeats of up to 20 in many individuals (although this is not necessarily the case). RP1 makes up structural domains in the N terminal while RP2 makes up structural domains in the C terminal.  . 
+PF12043 Domain of unknown function (DUF3527)<br>PFAM-B_3945 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain has a conserved CDCGGWD sequence motif.. 
+PF12044 Putative peptidase family<br>PFAM-B_3942 (release 23.0). This family of proteins is functionally uncharacterised. However, it does contain an HEXXH motif characteristic of metallopeptidases. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 625 to 773 amino acids in length.. 
+PF12045 Protein of unknown function (DUF3528)<br>PFAM-B_3981 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with Pfam:PF00046.. 
+PF12046 Protein of unknown function (DUF3529)<br>PFAM-B_3346 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 176 to 190 amino acids in length.. 
+PF12047 Cytosine specific DNA methyltransferase replication foci domain<br>This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties.  . 
+PF12048 Protein of unknown function (DUF3530)<br>PFAM-B_2450 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 272 to 336 amino acids in length. These proteins are distantly related to alpa/beta hydrolases so they may act as enzymes.. 
+PF12049 Protein of unknown function (DUF3531)<br>PFAM-B_2583 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 149 to 199 amino acids in length.. 
+PF12051 Protein of unknown function (DUF3533)<br>PFAM-B_2348 (release 23.0). This family of transmembrane proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.. 
+PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal<br>The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins.  . 
+PF12053 Domain of unknown function (DUF3534)<br>PFAM-B_2753 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 150 amino acids in length. This domain is found associated with Pfam:PF00595. This domain has a conserved GILD sequence motif.. 
+PF12054 Domain of unknown function (DUF3535)<br>PFAM-B_2858 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with Pfam:PF00271, Pfam:PF02985, Pfam:PF00176. This domain has two completely conserved residues (P and K) that may be functionally important.. 
+PF12055 Domain of unknown function (DUF3536)<br>PFAM-B_3129 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 274 to 285 amino acids in length. This domain is found associated with Pfam:PF03065.. 
+PF12056 Protein of unknown function (DUF3537)<br>PFAM-B_3199 (release 23.0). This family of transmembrane proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 427 to 453 amino acids in length.. 
+PF12057 Domain of unknown function (DUF3538)<br>PFAM-B_3373 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain is found associated with Pfam:PF00240. This domain has a conserved SDL sequence motif.. 
+PF12058 Protein of unknown function (DUF3539)<br>PFAM-B_3564 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved NHP sequence motif.. 
+PF12059 Protein of unknown function (DUF3540)<br>PFAM-B_2948 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 212 to 238 amino acids in length. This protein has a conserved SCL sequence motif.. 
+PF12060 Domain of unknown function (DUF3541)<br>PFAM-B_2172 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 230 amino acids in length.. 
+PF12061 Protein of unknown function (DUF3542)<br>PFAM-B_2032 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in eukaryotes and viruses. Proteins in this family are typically between 516 to 1283 amino acids in length. This protein is found associated with Pfam:PF00931.. 
+PF12062 heparan sulfate-N-deacetylase<br>PFAM-B_2134 (release 23.0). This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes.  This proteinenzyme is often found associated with Pfam:PF00685.. 
+PF12063 Domain of unknown function (DUF3543)<br>PFAM-B_2213 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 217 to 291 amino acids in length. This domain is found associated with Pfam:PF00069. This domain has a single completely conserved residue A that may be functionally important.. 
+PF12064 Domain of unknown function (DUF3544)<br>PFAM-B_3553 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 198 to 216 amino acids in length. This domain is found associated with Pfam:PF00628, Pfam:PF01753, Pfam:PF00439, Pfam:PF00855.. 
+PF12065 Protein of unknown function (DUF3545)<br>PFAM-B_3270 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 60 to 77 amino acids in length. This protein has two completely conserved residues (R and L) that may be functionally important.. 
+PF12066 Domain of unknown function (DUF3546)<br>PFAM-B_3237 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 93 to 114 amino acids in length. This domain has two completely conserved Y residues that may be functionally important.. 
+PF12067 DUF3547;<br>Sox C-terminal transactivation domain. PFAM-B_3310 (release 23.0). This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with Pfam:PF00505. It binds to the Armadillo repeats (Pfam:PF00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation  . It functions as a transactivating domain (TAD)  .. 
+PF12068 Domain of unknown function (DUF3548)<br>PFAM-B_3247 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 184 to 216 amino acids in length. This domain is found associated with Pfam:PF00566. This domain is found at the N-terminus of GYP7 proteins.. 
+PF12069 Protein of unknown function (DUF3549)<br>PFAM-B_2034 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 340 amino acids in length. This protein has a conserved LDE sequence motif.. 
+PF12070 Protein of unknown function (DUF3550/UPF0682)<br>PFAM-B_2472 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 249 to 606 amino acids in length.. 
+PF12071 Protein of unknown function (DUF3551)<br>PFAM-B_3610 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 79 to 104 amino acids in length. This protein has a single completely conserved residue C that may be functionally important.. 
+PF12072 Domain of unknown function (DUF3552)<br>PFAM-B_3508 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 200 amino acids in length. This domain is found associated with Pfam:PF00013, Pfam:PF01966. This domain has a single completely conserved residue A that may be functionally important.. 
+PF12073 Protein of unknown function (DUF3553)<br>PFAM-B_3361 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 60 amino acids in length. This protein has two conserved sequence motifs: GQVQS and TVNF.. 
+PF12074 Domain of unknown function (DUF3554)<br>PFAM-B_2029 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 287 to 356 amino acids in length. This domain is found associated with Pfam:PF02985.. 
+PF12075 KN motif<br>PFAM-B_3795 (release 23.0). This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with Pfam:PF00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors  .. 
+PF12076 WAX2 C-terminal domain<br>Pfam-B_3756  (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 170 amino acids in length.  This domain is found associated with Pfam:PF04116. This domain has a conserved LEGW sequence motif. This region has similarity to short chain dehydrogenases  .. 
+PF12077 Transmembrane protein of unknown function (DUF3556)<br>PFAM-B_2567 (release 23.0). This family of transmembrane proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 576 to 592 amino acids in length.. 
+PF12078 Domain of unknown function (DUF3557)<br>PFAM-B_2154 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 150 amino acids in length.. 
+PF12079 Protein of unknown function (DUF3558)<br>PFAM-B_3489 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.. 
+PF12080 GldM C-terminal domain<br>PFAM-B_3275 (release 23.0). This domain is found in bacteria at the C-terminus of the GldM protein. This domain is typically between 169 to 182 amino acids in length. This domain has two completely conserved residues (Y and N) that may be functionally important. GldM, is named for the member from Cytophaga johnsonae (Flavobacterium johnsoniae), which is required for a type of rapid gliding motility found in certain members of the Bacteriodetes  .. 
+PF12081 GldM N-terminal domain<br>PFAM-B_3275 (release 23.0). This domain is found in bacteria at the N-terminus of the GldM protein. This domain is typically between 169 to 182 amino acids in length. This domain has two completely conserved residues (Y and N) that may be functionally important. GldM, is named for the member from Cytophaga johnsonae (Flavobacterium johnsoniae), which is required for a type of rapid gliding motility found in certain members of the Bacteriodetes  .. 
+PF12083 Domain of unknown function (DUF3560)<br>PFAM-B_2138 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain has a conserved GHHSE sequence motif.. 
+PF12084 Protein of unknown function (DUF3561)<br>PFAM-B_2401 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.. 
+PF12085 Protein of unknown function (DUF3562)<br>PFAM-B_3549 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 62 to 84 amino acids in length. This protein has two completely conserved residues (A and Y) that may be functionally important.. 
+PF12086 Protein of unknown function (DUF3563)<br>PFAM-B_3639 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 50 amino acids in length. This protein has conserved AYL and DLE sequence motifs.. 
+PF12087 Protein of unknown function (DUF3564)<br>PFAM-B_3736 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 118 to 142 amino acids in length. This protein has a conserved WSRE sequence motif.. 
+PF12088 Protein of unknown function (DUF3565)<br>PFAM-B_3033 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 30 to 78 amino acids in length. This protein has two conserved sequence motifs: WVA and CGH.. 
+PF12089 Transmembrane domain of unknown function (DUF3566)<br>PFAM-B_3331 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.. 
+PF12090 Spt20 family<br>PFAM-B_3386 (release 23.0). This presumed domain is found in the Spt20 proteins from both human and yeast.  The Spt20 protein is part of the SAGA complex which is a large cmplex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.. 
+PF12091 Protein of unknown function (DUF3567)<br>PFAM-B_3056 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved EIVDK sequence motif.. 
+PF12092 Protein of unknown function (DUF3568)<br>PFAM-B_3573 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length.. 
+PF12093 Coronavirus NS8 protein<br>Pfam-B_2038 (Release 23.0). This family of proteins is functionally uncharacterised. This protein is found in coronaviruses. Proteins in this family are typically between 39 to 121 amino acids in length. This protein has two conserved sequence motifs: EDPCP and INCQ.. 
+PF12094 Protein of unknown function (DUF3570)<br>PFAM-B_3745 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 396 to 444 amino acids in length.. 
+PF12095 Protein of unknown function (DUF3571)<br>PFAM-B_3506 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 85 to 97 amino acids in length.. 
+PF12096 Protein of unknown function (DUF3572)<br>PFAM-B_2130 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 100 amino acids in length.. 
+PF12097 Protein of unknown function (DUF3573)<br>PFAM-B_2286 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 372 to 530 amino acids in length.. 
+PF12098 Protein of unknown function (DUF3574)<br>PFAM-B_3542 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 144 to 163 amino acids in length. This protein has a conserved TPRF sequence motif.. 
+PF12099 Protein of unknown function (DUF3575)<br>PFAM-B_2229 (release 23.0). This family of proteins are functionally uncharacterised. This family is only found in bacteria.  Proteins in this family are typically between 187 to 236 amino acids in length.. 
+PF12100 Domain of unknown function (DUF3576)<br>PFAM-B_2102 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 100 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.. 
+PF12101 Protein of unknown function (DUF3577)<br>PFAM-B_2116 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 143 to 307 amino acids in length.. 
+PF12102 Domain of unknown function (DUF3578)<br>PFAM-B_2328 (release 23.0). This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 177 to 191 amino acids in length.. 
+PF12103 Surface lipoprotein of Spirochaetales order<br>Lipl32 is an outer membrane surface lipoprotein of Leptospira like bacteria.. 
+PF12104 T cell CD4 receptor C terminal region<br>This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalisation. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure.. 
+PF12105 SpoU, rRNA methylase, C-terminal<br>PFAM-B_2024 (release 23.0). This domain is found in bacteria. This domain is about 60 amino acids in length. This domain is found in association with Pfam:PF00588. This domain has a conserved LFE sequence motif. Some members of the Pfam family SpoU_methylase, Pfam:PF00588, carry this very distinctive sequence region at their extreme C-terminus. The exact function of this region is not known.. 
+PF12106 Colicin C terminal ribonuclease domain<br>Colicin is a protein produced by bacteria with Col plasmids. Its function is to attack E. coli through actions on its inner membrane ion channels or through ribonuclease or deoxyribonuclease actions. The C terminal domain is the ribonuclease domain. It specifically cleaves tRNA anticodons which recognise codons in the form NAY (N:any nucleotide, A:adenosine, Y:pyrimidine) which corresponds to Tyrosine, Histidine, Asparagine and Aspartic Acid. E5-CRD can be referred to as an RNA restriction enzyme that specifically recognizes and cleaves single-stranded GU sequences.  . 
+PF12107 Plasminogen (Pg) ligand in fibrinolytic pathway<br>Pg is an important mediator of angiostatin production in the fibrinolytic pathway. Pg is made up of five subunit kringle molecules (Pg-K1 to Pg-K5), of which the first three make the protein angiostatin. VEK-30 is a domain of the group A streptococcal protein PAM. It binds to Pg-K2 of angiostatin and activates the molecule to mediate its anti-angiogenic effects. VEK-30 binds to angiostatin via a C terminal lysine with argininyl and glutamyl side chain residues known as a 'through space isostere'.  . 
+PF12108 Splicing factor SF3a60 binding domain<br>This domain is found in eukaryotes. This domain is about 30 amino acids in length. This domain has a single completely conserved residue Y that may be functionally important. SF3a60 makes up the SF3a complex with SF3a66 and SF3a120. This domain is the binding site of SF3a60 for SF3a120. The SF3a complex is part of the spliceosome, a protein complex involved in splicing mRNA after transcription.. 
+PF12109 CXCR4 Chemokine receptor N terminal<br>CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.  . 
+PF12110 Nuclear protein 96<br>Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is the point of curvature in the heptameric complex.    . 
+PF12111 Polyribonucleotide phosphorylase C terminal<br>PNPase regulates the expression of small non-coding RNAs that control expression of outer-membrane proteins. The enzyme also affects complex processes, such as the tissue-invasive virulence of Salmonella enterica and the regulation of a virulence-factor secretion system in Yersinia. In Escherichia coli, PNPase is involved in the quality control of ribosomal RNA precursors and is required for growth following cold shock. This family contains the C terminal protomer domain of the PNPase core.  The function of the C terminal protomer is to catalyse phosphorolysis through its two active sites.  . 
+PF12112 Protein of unknown function (DUF3579)<br>PFAM-B_2027 (release 23.0). This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 98 to 126 amino acids in length. This protein has a conserved FRP sequence motif.. 
+PF12113 SVM protein signal sequence<br>PFAM-B_2829 (release 23.0). This region is presumed to be a signal peptide sequence found in Sequence-variable mosaic (SVM) proteins  . This domain is found in phytoplasmas. This presumed signal sequence is about 30 amino acids in length.. 
+PF12114 Period protein 2/3C-terminal region<br>PFAM-B_2037 (release 23.0). This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with Pfam:PF08447.. 
+PF12115 Salivary protein of 15kDa inhibits CD4+ T cell activation<br>PFAM-B_2039 (release 23.0). This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.. 
+PF12116 Stage III sporulation protein D<br>PFAM-B_2045 (release 23.0). This stage III sporulation protein is a small DNA-binding family that is essential for gene expression of the mother-cell compartment during sporulation. The domain is found in bacteria and viruses, and is about 40 amino acids in length. It has a conserved RGG sequence motif.. 
+PF12117 DUF_B2046;<br>Protein of unknown function (DUF3580). PFAM-B_2046 (release 23.0). This domain is found in viruses, and is about 120 amino acids in length. It is found in association with Pfam:PF01057.. 
+PF12118 SprA-related family<br>PFAM-B_2057 (release 23.0). This protein is found in bacteria. Proteins in this family are typically between 234 to 465 amino acids in length. There is a conserved GEV sequence motif.Most members are annotated as being SprA-related.. 
+PF12119 Protein of unknown function (DUF3581)<br>PFAM-B_2081 (release 23.0). This protein is found in bacteria. Proteins in this family are about 240 amino acids in length.. 
+PF12120 DNApol_Rpb2_rif; RNApol_Rpb2_rif;<br>Rifampin ADP-ribosyl transferase. This protein is found in bacteria. Proteins in this family are typically between 136 to 150 amino acids in length. The opportunistic pathogen Mycobacterium smegmatis is resistant to rifampin because of the presence of a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). Arr-ms is a small enzyme whose activity thus renders rifamycin antibiotics ineffective  .. 
+PF12121 Dermaseptin<br>This protein is found in eukaryotes. Proteins in this family are typically between 30 to 76 amino acids in length. This protein is found associated with Pfam:PF03032. This domain is part of a dermaseptin protein which is used as an antimicrobial agent. The full protein is almost completely defined in an alpha helical domain. It creates high levels of disorder at the level of the phospholipid head group of bacterial membranes suggesting that it partitions into the bilayer where it severely disrupts membrane packing.. 
+PF12122 Protein of unknown function (DUF3582)<br>PFAM-B_2087 (release 23.0). This domain is found in bacteria, and is approximately 130 amino acids in length. It is found associated with Pfam:PF01694. There is a conserved ASW sequence motif. This domain has a single completely conserved residue F that may be functionally important.. 
+PF12123 N-acetylmuramoyl-l-alanine amidase<br>This domain is found in bacteria and viruses. This domain is about 50 amino acids in length. This domain is classified with the enzyme classification code EC:3.5.1.28. This domain is the C terminal of the enzyme which hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.. 
+PF12124 Coronavirus polyprotein cleavage domain<br>This domain is found in SARS coronaviruses, and is about 70 amino acids in length. It is found associated with various other coronavirus proteins due to the polyprotein nature of most viral translation. PL2pro is a domain of the non-structural protein nsp3. The domain performs three of the cleavages required to separate the translated polyprotein into its distinct proteins.. 
+PF12125 D domain of beta-TrCP<br>This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with Pfam:PF00646, Pfam:PF00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein.  Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.. 
+PF12126 Protein of unknown function (DUF3583)<br>PFAM-B_2092 (release 23.0). This domain is found in eukaryotes, and is typically between 302 and 338 amino acids in length. It is found in association with Pfam:PF00097 and Pfam:PF00643. Most members are promyelocytic leukemia proteins, and this family lies towards the C-terminus.. 
+PF12127 SigmaW regulon antibacterial<br>PFAM-B_2114 (release 23.0). This protein is found in bacteria. Proteins in this family are about 330 amino acids in length. The operon from which this protein is derived confers immunity for the host species to a broad range of antibacterial compounds, unlike the specific immunity proteins that are linked to and co-regulated with their antibiotic-synthesis proteins.. 
+PF12128 Protein of unknown function (DUF3584)<br>PFAM-B_2142 (release 23.0). This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.. 
+PF12129 Male germ-cell putative homeodomain transcription factor<br>PFAM-B_2140 (release 23.0). This domain is found in bacteria and eukaryotes, and is typically between 101 and 140 amino acids in length. Phtf proteins do not display any sequence similarity to known or predicted proteins, but their conservation among species suggests an essential function. The 84 kDa Phtf1 protein is an integral membrane protein, anchored to a cell membrane by six to eight trans-membrane domains, that is associated with a domain of the endoplasmic reticulum (ER) juxtaposed to the Golgi apparatus. It is present during meiosis and spermiogenesis, and, by the end of spermiogenesis, is released from the mature spermatozoon within the residual bodies  . Phtf1 enhances the binding of FEM1B -feminisation homologue 1B - to cell membranes. Fem-1 was initially identified in the signaling pathway for sex determination, as well as being implicated in apoptosis, but its biochemical role is still unclear, and neither FEM1B nor PHTF1 is directly implicated in apoptosis in spermatogenesis. It is the ANK domain of FEM1B that is necessary for the interaction with the N-terminal region of Phtf1  .. 
+PF12130 Protein of unknown function (DUF3585)<br>PFAM-B_2156 (release 23.0). This domain is found in eukaryotes. This domain is typically between 135 and 149 amino acids in length and is found associated with Pfam:PF00307.. 
+PF12131 Protein of unknown function (DUF3586)<br>PFAM-B_2164 (release 23.0). This domain is found in eukaryotes. This domain is about 80 amino acids in length and is found associated with Pfam:PF08246, and Pfam:PF00112.. 
+PF12132 Protein of unknown function (DUF3587)<br>PFAM-B_2181 (release 23.0). This protein is found in viruses. Proteins in this family are typically between 209 and 248 amino acids in length.. 
+PF12133 Open reading frame 6 from SARS coronavirus<br>PfamB-2188 (release 23.0). This family is found in Coronaviruses. Proteins in this family are typically between 42 to 63 amino acids in length.. 
+PF12134 PRP8 domain IV core<br>This domain is found in eukaryotes, and is about 20 amino acids in length. It is found associated with Pfam:PF10597, Pfam:PF10596, Pfam:PF10598, Pfam:PF08083, Pfam:PF08082, Pfam:PF01398, Pfam:PF08084. There is a conserved LILR sequence motif. The domain is a selenomethionine domain in a subunit of the spliceosome. The function of PRP8 domain IV is believed to be interaction with the splicosomal core.. 
+PF12135 Sialidase enzyme penultimate C terminal domain<br>This domain is found in bacteria and eukaryotes, and is about 30 amino acids in length. The protein from which this domain is found is a sialidase enzyme which is used by virulent bacteria as a toxin. It is the penultimate C terminal domain.. 
+PF12136 RNA polymerase Rpo13 subunit HTH domain<br>This domain is found in archaea, and is about 40 amino acids in length. It has a single completely conserved residue E that may be functionally important. It is found in the archaeal DNA dependent RNA polymerase. The domain is a 'helix-turn-helix' (HTH) domain in the Rpo13 subunit of the RNA polymerase. This domain is involved in downstream DNA binding, and the entire subunit has also been implicated in contacting transcription factor II B.. 
+PF12137 RNA polymerase recycling family C-terminal<br>PFAM-B_2201 (release 23.0). This domain is found in bacteria. This domain is about 360 amino acids in length. This domain is found associated with Pfam:PF00271, Pfam:PF00176. The function of this domain is not known, but structurally it forms an alpha-beta fold in nature with a central beta-sheet flanked by helices and loops, the beta-sheet being mainly antiparallel and flanked by four alpha helices, among which the two longer helices exhibit a coiled-coil arrangement.. 
+PF12138 Spherulation-specific family 4<br>PFAM-B_2198 (release 23.0). This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 250 and 398 amino acids in length.  There is a conserved NPG sequence motif and there are two completely conserved G residues that may be functionally important. Starvation will often induce spherulation - the production of spores - and this process may involve DNA-methylation. Changes in the methylation of spherulin4 are associated with the formation of spherules, but these changes are probably transient. Methylation of the gene accompanies its transcriptional activation, and spherulin4 mRNA is only detectable in late spherulating cultures and mature spherules. It is a spherulation-specific protein.. 
+PF12139 Adenosine-5'-phosphosulfate reductase beta subunit<br>PFAM-B_2202 (release 23.0). This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 112 to 142 amino acids in length. This family is found in association with Pfam:PF00037, and has a conserved FPIRTT sequence motif. The whole beta subunit has the enzymic properties of EC:1.8.99.2.. 
+PF12140 Protein of unknown function (DUF3588)<br>PFAM-B_2205 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with Pfam:PF02820. The exact function of this family is not known.. 
+PF12141 Protein of unknown function (DUF3589)<br>PFAM-B_2240 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 541 and 717 amino acids in length. The function of this family is not known,. 
+PF12142 Polyphenol oxidase middle domain<br>PFAM-B_2219 (release 23.0). This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length, and the family is found in association with Pfam:PF00264. Most members are annotated as being polyphenol oxidases, and many are from plants or plastids. There is a conserved DWL sequence motif which gives the family its name.. 
+PF12143 Protein of unknown function (DUF_B2219)<br>PFAM-B_2219 (release 23.0). This domain family is found in eukaryotes, and is typically between 138 and 152 amino acids in length. and the family is found in association with Pfam:PF00264. Many members are plant or plastid polyphenol oxidases, and there is a highly conserved sequence motif: KFDV, from which the name derives. This is the C-terminal domain of these oxidases.. 
+PF12144 Eukaryotic Mediator 12 catenin-binding domain<br>PFAM-B_2250 (release 23.0). 
+PF12145 Eukaryotic Mediator 12 subunit domain<br>PFAM-B_2250 (release 23.0). This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.. 
+PF12146 Putative lysophospholipase<br>PFAM-B_2243 (release 23.0). This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. Many members are annotated as being lysophospholipases, and others as alpha-beta hydrolase fold-containing proteins.. 
+PF12147 Hydrolase_5;<br>Putative methyltransferase. PFAM-B_2243 (release 23.0). This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. The family shows homology to methyltransferases.. 
+PF12148 Protein of unknown function (DUF3590)<br>This domain is found in eukaryotes, and is typically between 83 and 97 amino acids in length. It is found in association with Pfam:PF00097, Pfam:PF02182, Pfam:PF00628, Pfam:PF00240. There are two conserved sequence motifs: RAR and NYN. The domain is part of the protein NIRF which has zinc finger and ubiquitinating domains. The function of this domain is likely to be mainly structural, however this has not been confirmed.. 
+PF12149 Herpes simplex virus virion protein 16 C terminal<br>This domain is found in viruses, and is about 30 amino acids in length. It is found in association with Pfam:PF02232. This domain is the C terminal of the HSV virion protein 16. This protein is a transcription promoter. The C terminal domain is the carboxyl subdomain of the acidic transcriptional activation domain. The protein binds to DNA binding proteins to carry out its function. Such proteins include TATA binding protein, CBP, TBP-binding protein, etc.. 
+PF12150 Cytosolic motility protein<br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are found in nematodes. They complex with MSP (major sperm protein) to allow motility. Their action is quite similar to the action of bacterial actin molecules.. 
+PF12151 Mannan-binding protein<br>This domain family is found in bacteria, and is approximately 40 amino acids in length, There is a single completely conserved residue G that may be functionally important. The domain occurs in two types of proteins. In mannan binding proteins  , it forms a homodimeric molecule which complexes into a homo-octamer. In thiamidases it occurs without repeats but in the presence of other domains. MVL is distinct amongst other oligomannoside binding proteins in that it exhibits specificity for certain tetrasaccharides. Each molecule of MVL has four distinct carbohydrate binding sites.. 
+PF12152 Eukaryotic translation initiation factor 4G1<br>This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with Pfam:PF02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.. 
+PF12153 LPS binding domain of CAP18 (C terminal)<br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length, and the family is found in association with Pfam:PF00666. CAP18 is a protein which is derived from rabbit granulocytes. It has two domains, an N terminal DUF and a C terminal Gram negative LPS binding domain. This domain is the C terminal domain.. 
+PF12154 Glycoprotein B N-terminal antigenic domain of HCMV<br>PFAM-B_2260 (release 23.0). This domain is found in viruses, and is approximately 40 amino acids in length. The domain is found in association with Pfam:PF00606. There are two conserved sequence motifs: SVS and TSS. This family is the amino-terminal antigenic domain of glycoprotein B of human cytomegalovirus.. 
+PF12155 NADH dehydrogenase subunit 2 N-terminal<br>PFAM-B_2270 (release 23.0). This domain is found in eukaryotes, and is approximately 90 amino acids in length. It is found associated with Pfam:PF00361. All members are annotated as being NADH dehydrogenase subunit 2, and this region is the N-terminus.. 
+PF12156 Putative metal-binding domain of cation transport ATPase<br>PFAM-B_2287 (release 23.0). This domain is found in bacteria, and is approximately 90 amino acids in length. It is found associated with Pfam:PF00403, Pfam:PF00122, Pfam:PF00702. The cysteine-rich nature and composition suggest this might be a cation-binding domain; most members are annotated as being cation transport ATPases.. 
+PF12157 Protein of unknown function (DUF3591)<br>PFAM-B_2298 (release 23.0). This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.. 
+PF12158 Protein of unknown function (DUF3592)<br>PFAM-B_2016 (release 23.0). This family of proteins is functionally uncharacterised.This family of proteins is found in  bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.. 
+PF12159 Protein of unknown function (DUF3593)<br>PFAM-B_2028 (release 23.0). This family of proteins is functionally uncharacterised.This family of proteins is found in  bacteria and eukaryotes. Proteins in this family are typically between 98 and 228 amino acids in length. There is a conserved LHG sequence motif.. 
+PF12160 Fibrinogen alpha C domain<br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with Pfam:PF08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.. 
+PF12161 HsdM N-terminal domain<br>PFAM-B_2036 (release 23.0). This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with Pfam:PF02384. Mutations in this region of EcoKI methyltransferase Swiss:P08957 abolish the normally strong preference of this system for methylating hemimethylated substrate  .  The structure of this domain has been shown to be all alpha-helical.. 
+PF12162 STAT1 TAZ2 binding domain<br>This domain family is found in eukaryotes, and is approximately 20 amino acids in length, and the family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. This domain is the C terminal domain of STAT1. This domain binds selectively to the TAZ2 domain of CRB (CREB-binding protein). In this process it becomes a transcriptional activator and can initiate transcription of certain genes.. 
+PF12163 DNA replication regulator<br>This family of proteins is found exclusively in epsilon-proteobacteria. Proteins in this family are approximately 180 amino acids in length. The structure of HobA is a modified Rossmann fold consisting of a five-stranded parallel beta-sheet (beta1-5) flanked on one side by alpha-2, alpha-3 and alpha-6 helices and alpha-4 and alpha-5 on the other. The alpha-1 helix is extended away from and has minimal interaction with the globular part of the protein. Four monomers interact to form a tetrameric molecule. Four calcium atoms bind to the tetramer and these binding sites may have functional relevance. The function of HobA is to regulate DNA replication and its does this by binding to DNA-A, but the exact mechanism of how this regulation occurs is purely speculative. 
+PF12164 SporV_proteinAA;<br>Stage V sporulation protein AA. This domain family is found in bacteria - primarily Firmicutes, and is approximately 90 amino acids in length. There is a single completely conserved residue G that may be functionally important. Most annotation associated with this domain suggests that it is involved in the fifth stage of sporulation, however there is little publication to back this up.. 
+PF12165 Domain of unknown function (DUF3594)<br>PFAM-B_2040 (release 23.0). This presumed domain is functionally uncharacterised.This domain family is found in  eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00628.. 
+PF12166 Protein of unknown function (DUF3595)<br>PFAM-B_2166 (release 23.0). This family of proteins is functionally uncharacterised.This family of proteins is found in  eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.. 
+PF12167 Domain of unknown function (DUF3596)<br>PFAM-B_2234 (release 23.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00589. It is likely that this domain acts to bind DNA.. 
+PF12168 DNA polymerase III subunits tau domain IV DnaB-binding<br>PFAM-B_2296 (release 23.0). This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.. 
+PF12169 DNA polymerase III subunits gamma and tau domain III<br>PFAM-B_2296 (release 23.0). This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.. 
+PF12170 DNA polymerase III tau subunit V interacting with alpha<br>PFAM-B_2296 (release 23.0). This domain family is found in bacteria, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau. The extreme C-terminal region of this domain 5 is the part which interacts with the alpha subunit of the DNA polymerase III holoenzyme.. 
+PF12171 Zinc-finger double-stranded RNA-binding<br>PFAM-B_2302 (release 23.0). This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.. 
+PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N)<br>Pfam-B_1390 (release 4.2). This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins.  The domain is duplicated in Swiss:O53566.  The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain represented in this family and a C-terminal OB fold domain. Zinc is chelated by the four conserved cysteines in the alignment.. 
+PF12173 Bacteriocin class IIc cyclic gassericin A-like<br>PfamB_170026 (release 23.0), manual. This class of bacteriocins was previously described as class V. The members include gassericin A, acidocin B and butyrovibriocin AR10, all of which are hydrophobic cyclical structures  . The N- and C-termini are covalently linked, and the circular molecule is resistant to several proteases and peptidases  . The immunity protein that protects Lactobacillus gasseri from the toxic effects of its bacteriocin, gassericin A, has been identified. It is found to be a small positively-charged hydrophobic peptide of 53 amino acids containing a putative transmembrane segment   - a structure unlike that of the more common immunity proteins as found in Pfam:PF08951.. 
+PF12174 RCD1-SRO-TAF4 (RST) plant domain<br>Overmyer K, Coggill P. Pfam-B_8550 (release 23.0). This domain is found in plant RCD1, SRO and TAF4 proteins, hence its name of RST. It is required for interaction with multiple plant transcription factors. Radical-Induced Cell Death1 (RCD1) is an important regulator of stress and hormonal and developmental responses in Arabidopsis thaliana, as is its closest homologue, SRO1 - Similar To RCD-One1. TBP-Associated Factor 4 (TAF4) and TAF4-b are components of the transcription initiation factor complex TFIID.. 
+PF12175 White spot syndrome virus structural envelope protein VP<br>This family of proteins is found in viruses. Proteins in this family are approximately 210 amino acids in length. There is a conserved NNT sequence motif.  These proteins are structural envelope proteins in viruses. This is the beta barrel C terminal domain. There is a protruding N terminal domain which completes the proteins. Three of four envelope proteins in white spot syndrome virus share sequence homology with each other and are present in this family - VP24, VP26 and VP28. VP19 is the other major envelope protein but shares no sequence homology with the other proteins. These proteins are essential for entry into cells of the crustacean host.. 
+PF12176 Methanol-cobalamin methyltransferase B subunit<br>This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 460 amino acids in length. MtaB folds as a TIM barrel and contains a novel zinc-binding motif. Zinc(II) lies at the bottom of a funnel formed at the C-terminal beta-barrel end and ligates to two cysteinyl sulfurs (Cys-220 and Cys-269) and one carboxylate oxygen (Glu-164). The function of this protein is to catalyse the cleavage of the C O bond in methanol by an SN2 mechanism. It complexes with MtaA and MtaC to perform this function.. 
+PF12177 Prohormone convertase enzyme<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF01483, Pfam:PF00082. There are two completely conserved residues (Y and D) that may be functionally important. This protein is the C terminal domain of a prohormone convertase enzyme which targets hormones in dense core secretory granules. This C terminal tail domain is the domain responsible for targeting these dense core secretory granules. The domain adopts an alpha helical structure. . 
+PF12178 Chromosome passenger complex (CPC) protein INCENP N terminal<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.. 
+PF12179 I-kappa-kinase-beta NEMO binding domain<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.. 
+PF12180 TSG101 and ALIX binding domain of CEP55<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.. 
+PF12181 DNA binding domain of the motility gene repressor (MogR)<br>This domain family is found in bacteria, and is approximately 150 amino acids in length. MogR is involved in repression of transcription of the flagellar gene in Listeria bacteria. This allows a phenotypical switch from an extracellular bacterium to an intracellular pathogen. MogR binds AT rich flagellar gene promoter regions upstream of the flagellar gene. These regions follow the pattern 5'-TTTTNNNNNAAAA-3'. This domain is the DNA binding domain of MogR.. 
+PF12182 Lipoprotein;<br>Bacterial lipoprotein. This domain family is found in bacteria, and is approximately 60 amino acids in length. There is a single completely conserved Y residue that may be functionally important. This domain is from a bacterial lipoprotein, a major virulence factor in Gram negative bacteria.. 
+PF12183 Restriction endonuclease NotI<br>This family of proteins is found in bacteria. Proteins in this family are typically between 270 and 341 amino acids in length. There is a conserved CPF sequence motif. The type IIP restriction enzyme, NotI, is a homodimer that recognizes the 8 bp DNA sequence 5'-GC/GGCCGC-3' and cleaves both strands of DNA to create 5', 4 base cohesive overhangs.. 
+PF12185 Nup358/RanBP2 E3 ligase domain<br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00638, Pfam:PF00641, Pfam:PF00160. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.. 
+PF12186 Acyl-CoA dehydrogenase C terminal<br>This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF02770, Pfam:PF00441, Pfam:PF02771. There is a conserved ARRL sequence motif. The C terminal domain is an alpha helical domain. The flavin ring of Acyl-CoA dehydrogenase is buried in the crevice between the two alpha helical domains and the beta-sheet domain of one subunit, and the adenosine pyrophosphate moiety is stretched into the subunit junction of a neighbouring subunit, composed of two C terminal domains.. 
+PF12187 Viral/Archaeal nuclease<br>This family of proteins is found in archaea and viruses. Proteins in this family are typically between 211 and 244 amino acids in length. These proteins are nucleases from fusseloviruses and sulfolobus archaea.. 
+PF12188 STAT2_Cterm;<br>Signal transducer and activator of transcription 2 C terminal. This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. There is a conserved DLP sequence motif. STATs are involved in transcriptional regulation and are the only regulators known to be modulated by tyrosine phosphorylation. STAT2 forms a trimeric complex with STAT1 and IRF-9 (Interferon Regulatory Factor 9), on activation of the cell by interferon, which is called ISGF3 (Interferon-stimulated gene factor 3). The C terminal domain of STAT2 contains a nuclear export signal (NES) which allows export of STAT2 into the cytoplasm along with any complexed molecules.. 
+PF12189 Single-strand DNA-binding protein<br>This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved IELE sequence motif. VirE1 is an acidic chaperone protein which binds to VirE2, a ssDNA binding protein. These proteins are virulence factors of the plant pathogens Agrobacteria. VirE1 competes for the ssDNA binding site of VirE2.. 
+PF12190 Fungal protease inhibitor<br>This protein family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are fungal protease inhibitors.. 
+PF12191 Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumour necrosis factor receptor. The function of this domain is unknown.. 
+PF12192 Fungal calcium binding protein<br>This domain is found in eukaryotes, and is approximately 60 amino acids in length. There is a single completely conserved residue C that may be functionally important. This is a calcium binding domain from the fungal protein CBP (calcium binding protein). This protein is a virulence factor with unknown virulence mechanisms. CBP complexes as a highly intertwined homodimer. Each monomer is comprised of four alpha helices which adopt the saposin fold, characteristic of a protein family that binds to membranes and lipids.. 
+PF12193 Sulf_coatprot_C;<br>Sulfolobus virus coat protein C terminal. This domain family is found in viruses, and is approximately 70 amino acids in length. It is the C terminal of a coat protein in sulfolobus viruses.. 
+PF12194 ste5minscaffold;<br>Protein kinase Fus3-binding. This domain family is found in eukaryotes, and is approximately 190 amino acids in length. This domain is the penultimate C terminal domain from the protein ste5 which co-catalyses the phosphorylation of fus3 by ste7. It is involved in the MAPK pathways. This domain is the minimal scaffold domain of ste5. It binds to the mitogen activated protein kinase fus3 before it is phosphorylated.. 
+PF12195 Endosialidase; Endobetabarrel;<br>Beta barrel domain of bacteriophage endosialidase. This domain family is found in bacteria and viruses, and is approximately 80 amino acids in length.This domain is the beta barrel domain of bacteriophage endosialidase which represents the one of the two sialic acid binding sites of the enzyme. The domain is nested in the beta propeller domain of the endosialidase enzyme. The endosialidase protein complexes to form homotrimeric molecules.. 
+PF12196 FHA Ki67 binding domain of hNIFK<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00076. There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.. 
+PF12197 Bacillus cereus group antimicrobial protein<br>This domain is found in bacteria, and is approximately 40 amino acids in length. This domain is found in bacillus cereus group bacteria. It is an antimicrobial protein.. 
+PF12198 Theoretical tuberculin protein<br>This domain family is found in bacteria, and is approximately 30 amino acids in length. This protein is a theoretical model of the tuberculin protein from Mycobacterium tuberculosis.. 
+PF12199 Extracellular fibrinogen binding protein C terminal<br>This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.. 
+PF12200 Domain of unknown function (DUF3597)<br>This family of proteins is found in bacteria, eukaryotes and viruses.  Proteins in this family are typically between 126 and 281 amino acids in length. The function of this domain is unknown. The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two.. 
+PF12201 Bcl2-interacting killer, BH3-domain containing<br>This is a family of pro-apoptotic Bcl-x proteins, B cell leukaemia/lymphoma 2, or BIKs.  BIK proteins rely for their activity upon an intact BH3 domain lying between residues 48 and 80, as in UniProt:Q13323.. 
+PF12202 Oxidative-stress-responsive kinase 1 C terminal<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00069. There is a single completely conserved residue F that may be functionally important. OSR1 is involved in the signalling cascade which activates Na/K/2Cl cotransporter during osmotic stress. This domain is the C terminal domain of OSR1 which recognises a motif (Arg-Phe-Xaa-Val) on the OSR1-activating protein WNK1.. 
+PF12203 Glutamine rich N terminal domain of histone deacetylase 4<br>This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.. 
+PF12204 Domain of unknown function (DUF3598)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 230 and 398 amino acids in length. These proteins are formed entirely from B sheets which form a barrel structure similar to those seen in the lipocalin superfamily.. 
+PF12205 G protein-coupled receptor kinase-interacting protein 1 C term<br>This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF01412, Pfam:PF00023, Pfam:PF08518. GIT1 plays an important role in cell adhesion, motility, cytoskeletal remodeling and membrane trafficking. To perform this function, it localises p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulated by interaction between its paxillin-binding C terminal and the LD motifs of paxillin. The C terminal folds into a four helix bundle.. 
+PF12206 Domain of unknown function (DUF3599)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. This domain is the phage-like element pbsx protein xkdh.. 
+PF12207 Domain of unknown function (DUF3600)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 230 amino acids in length. This domain is the C terminal of the putative ecf-type sigma factor negative effector.. 
+PF12208 Domain of unknown function (DUF3601)<br>This domain family is found in bacteria, and is approximately 80 amino acids in length.. 
+PF12209 Leucine permease transcriptional regulator helical domain<br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF03399. This domain is a helical domain in the middle of leucine permease transcriptional regulator.. 
+PF12210 Hepatocyte growth factor-regulated tyrosine kinase substrate<br>This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00790, Pfam:PF01363, Pfam:PF02809. This domain is the helical region of Hrs which forms the core complex of ESCRT with STAM.. 
+PF12211 Low molecular weight S layer protein N terminal<br>This family of proteins is found in bacteria. Proteins in this family are typically between 328 and 381 amino acids in length. There is a conserved LGDG sequence motif. Clostridial species have a layer of surface proteins surrounding their membrane. This layer is comprised of a high molecular weight protein and a low molecular weight protein. This domain is the N terminal domain of the low molecular weight protein. It is a structural domain.. 
+PF12212 Piwi/Argonaute/Zwille siRNA-binding domain<br>This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There is a conserved LKDIL sequence motif. There is a single completely conserved residue L that may be functionally important. This domain is part of an Argonaute protein. It is an siRNA binding domain.. 
+PF12213 DNA polymerases epsilon N terminal<br>This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains.. 
+PF12214 Cell cycle regulated microtubule associated protein<br>PFAM-B_2368 (release 23.0). This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with Pfam:PF06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain.. 
+PF12215 beta-Glucocerebrosidase 2 N terminal<br>PFAM-B_2416 (release 23.0). This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 320 to 354 amino acids in length. This domain is found associated with Pfam:PF04685. This domain is found in the protein beta-Glucocerebrosidase 2. It is found just after the extreme N terminus. This protein is located in the ER. The N terminal is thought to be the luminal domain while the C terminal is the cytosolic domain. The catalytic domain of GBA-2 is unknown.. 
+PF12216 Immune evasion protein<br>PFAM-B_2496 (release 23.0). This protein is found in archaea and viruses. Proteins in this family are typically between 265 to 342 amino acids in length. The proteins in this family are or are related to the m04 encoded protein gp34 of pathogenic microorganisms such as murine cytomegalovirus. m06 and m152 genes are expressed earlier in the intracellular replication phases of these microorganism' life cycles. They function to inhibit MHC-1 loading and export. gp34 is theorized to prevent immune reactions from NK cells which would ordinarily recognise and attack cells lacking MHC.. 
+PF12217 Catalytic beta propeller domain of bacteriophage endosialidase<br>This domain family is found in bacteria and viruses, and is typically between 443 and 460 amino acids in length. This domain is the highly conserved beta propeller of bacteriophage endosialidase which represents the catalytically active part of the enzymes. This core domain forms stable SDS-resistant trimers. There is a nested beta barrel domain in this domain (Pfam:PF12195). The endosialidase protein complexes to form a homotrimeric molecule.. 
+PF12218 N terminal extension of bacteriophage endosialidase<br>This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. This domain is found in the bacteriophage protein endosialidase. The two N-terminal domains (this domain and the beta propeller) assemble in the compact 'cap' whereas the C-terminal domain forms an extended tail-like structure. The very N-terminal part of the 'cap' region (residues 246 to 312) holds the only alpha-helix of the protein and is presumably the residual part of the deleted N-terminal head-binding domain. The endosialidase protein complexes to form homotrimeric molecules.. 
+PF12219 Catalytic domain of bacteriophage endosialidase<br>This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two conserved sequence motifs: VSR and YGA. This domain is the C terminal domain of the bacteriophage protein endosialidase. The endosialidase protein forms homotrimeric molecules and this domain complexes into a tail-spike stalk. The stalk region folds in a triple beta-helix that is interrupted by a small triple beta-prism domain. The tail-spike is a multifunctional protein device used by the phage to fulfill the following functions: (i) to adsorb to the bacterial polySia capsule (ii) to de-polymerise the capsule to gain access to the outer bacterial membrane, and finally (iii) to mediate tight adhesion to the membrane, a prerequisite for the initiation of the infection cycle.. 
+PF12220 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal<br>PFAM-B_2533 (release 23.0). This domain is found in eukaryotes. This domain is about 90 amino acids in length. This domain is found associated with Pfam:PF00076. This domain is part of U1 snRNP, which is the pre-mRNA binding protein of the penta-snRNP spliceosome complex. It extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition.. 
+PF12221 Bacterial membrane protein N terminal<br>PFAM-B_2550 (release 23.0). This domain is found in bacteria. This domain is typically between 65 to 81 amino acids in length. This domain is found associated with Pfam:PF01145. This domain is the N terminal of the bacterial membrane protein HflK. HflK complexes with HflC to form a membrane protease which is modulated by the GTPase HflX. The N terminal domain of HflK is the membrane spanning region which anchors the protein in the bacterial membrane.. 
+PF12222 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A<br>PFAM-B_2578 (release 23.0). This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 558 and 775 amino acids in length. There is a conserved TGG sequence motif. PNGase A is a protein which cleaves glycopeptides.. 
+PF12223 Protein of unknown function (DUF3602)<br>PFAM-B_2582 (release 23.0). This domain family is found in eukaryotes, and is typically between 78 and 89 amino acids in length.. 
+PF12224 Putative amidoligase enzyme<br>This family of proteins are likely to act as amidoligase enzymes   Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes)  .. 
+PF12225 Methylene-tetrahydrofolate reductase C terminal<br>PFAM-B_2600 (release 23.0). This family is found in bacteria and archaea, and is approximately 100 amino acids in length. There is a conserved NGPCGG sequence motif. This family is the C terminal of methylene-tetrahydrofolate reductase. This protein reduces FAD using the reducing equivalents from reduced FAD, subsequently reduces tetrahydrofolate. The C terminal of MTHFR contains the FAD binding site and is the catalytic portion of the enzyme.. 
+PF12226 Turkey astrovirus capsid protein<br>PFAM-B_2608 (release 23.0). This family of proteins is found in viruses. Proteins in this family are typically between 241 and 261 amino acids in length. These proteins are capsid proteins from various astrovirus strains.. 
+PF12227 Protein of unknown function (DUF3603)<br>PFAM-B_2609 (release 23.0). This protein is found in bacteria and eukaryotes. Proteins in this family are about 250 amino acids in length.. 
+PF12228 Protein of unknown function (DUF3604)<br>PFAM-B_2610 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 621 and 693 amino acids in length.. 
+PF12229 Putative peptidoglycan binding domain<br>
+PF12230 Pre-mRNA splicing factor PRP21 like protein<br>PFAM-B_2642 (release 23.0). This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with Pfam:PF01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.. 
+PF12231 Rap1-interacting factor 1 N terminal<br>Assefa S, Gavin OL, Eberhardt R. PFAM-B_2647 (release 23.0). This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.. 
+PF12232 Myogenic determination factor 5<br>PFAM-B_2654 (release 23.0). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00010, Pfam:PF01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.. 
+PF12233 Human adult T cell leukemia/lymphoma virus protein<br>PFAM-B_2655 (release 23.0). This family of proteins is found in viruses. Proteins in this family are approximately 100 amino acids in length. p12I binds to the immature beta and gamma-c chains of the interleukin-2 receptor retarding their translocation to the plasma membrane. p12I forms dimers which bind to these chains.. 
+PF12234 RAVE protein 1 C terminal<br>PFAM-B_2692 (release 23.0). This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.. 
+PF12235 Fragile X-related 1 protein C terminal<br>PFAM-B_2701 (release 23.0). This domain family is found in eukaryotes, and is typically between 126 and 160 amino acids in length. The family is found in association with Pfam:PF05641, Pfam:PF00013. This family is the C terminal region of the fragile X related 1 protein FXR1P. FXR1P contains two KH domains and a RGG box that are characteristic motifs in RNA-binding proteins as well as nuclear localization and export signals. FXR1P is thought to regulate mRNA transport and translation.. 
+PF12236 Bacteriophage head to tail connecting protein<br>PFAM-B_2709 (release 23.0). This family of head-tail connector proteins is found in bacteria and viruses. Proteins in this family are typically between 516 and 555 amino acids in length.  This protein is found in Phage T7 and T3 among others.. 
+PF12237 Phosphorylated CTD interacting factor 1 WW domain<br>PFAM-B_2805 (release 23.0). This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.. 
+PF12238 Merozoite surface antigen 2c<br>PFAM-B_2755 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species.. 
+PF12239 Protein of unknown function (DUF3605)<br>PFAM-B_2795 (release 23.0). This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 161 and 256 amino acids in length.. 
+PF12240 Angiomotin C terminal<br>PFAM-B_2808 (release 23.0). This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin  . The C terminal region of angiomotin appears to be involved in directing the protein chemotactically  .. 
+PF12241 Trans-2-enoyl-CoA reductase catalytic region<br>Vella Briffa B, Coggill P. Pfam-B_10602 (release 10.0). This family of trans-2-enoyl-CoA reductases, EC:1.3.1.44, carries the the catalytic sites of the enzyme, characterised by the conserved sequence motifs: YNThhhFxK, and YShAPxR. In Euglena where the enzyme has been characterised it catalyses the reduction of enoyl-CoA to acyl-CoA in an unusual fatty acid pathway in mitochondria. the whole path performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation.. 
+PF12242 NAD(P)H binding domain of trans-2-enoyl-CoA reductase<br>Vella Briffa B, Coggill P. Pfam-B_10602 (release 10.0). This family carries the region of the enzyme trans-2-enoyl-CoA reductase, EC:1.3.1.44, which binds NAD(P)H. The activity of the enzyme was characterised in Euglena where an unusual fatty acid synthesis path-way in the mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The binding site is conserved as GA/CSpGYG, where p is any polar residue  .. 
+PF12243 CTD kinase subunit gamma CTK3<br>Pfam-B_12814 (release 23.0). The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation  . The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2  .. 
+PF12244 Protein of unknown function (DUF3606)<br>PFAM-B_2813 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 85 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF12245 DUF3607;<br>Bacterial Ig-like domain (group 3). PFAM-B_2816 (release 23.0). This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.. 
+PF12246 Temperature dependent protein affecting M2 dsRNA replication<br>PFAM-B_2862 (release 23.0). This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.. 
+PF12247 Temperature dependent protein affecting M2 dsRNA replication<br>PFAM-B_2862 (release 23.0). This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the N terminal region of MKT1.. 
+PF12248 Farnesoic acid 0-methyl transferase<br>PFAM-B_2872 (release 23.0). This domain family is found in bacteria and eukaryotes, and is approximately 110 amino acids in length.Farnesoic acid O-methyl transferase (FAMeT) is the enzyme that catalyses the formation of methyl farnesoate (MF) from farnesoic acid (FA) in the biosynthetic pathway of juvenile hormone (JH).. 
+PF12249 Arabinofuranosyltransferase A C terminal<br>PFAM-B_2900 (release 23.0). This domain family is found in bacteria, and is typically between 179 and 190 amino acids in length. This family is the C terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The C terminal region is predicted to be directed towards the periplasm.. 
+PF12250 Arabinofuranosyltransferase N terminal<br>PFAM-B_2900 (release 23.0). This domain family is found in bacteria, and is typically between 430 and 441 amino acids in length. This family is the N terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The N terminal region has been predicted to span 11 transmembrane regions.. 
+PF12251 snRNA-activating protein of 50kDa MW C terminal<br>PFAM-B_2919 (release 23.0). This domain family is found in eukaryotes, and is typically between 196 and 207 amino acids in length. There is a conserved CEH sequence motif. SNAP50 is part of the snRNA-activating protein complex which activates RNA polymerases II and III. There is a cysteine-histidine cluster which contains two possible zinc finger motifs.. 
+PF12252 Dot/Icm substrate protein<br>PFAM-B_2926 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 397 and 1543 amino acids in length. This family is the SidE protein in the Dot/Icm pathway of Legionella pneumophila bacteria. There is little literature describing the family.. 
+PF12253 CAF1B;<br>Chromatin assembly factor 1 subunit A. The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A  . The A domain is uniquely required for the progression of S phase in mouse cells  , independent of its ability to promote histone deposition   but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints  .. 
+PF12254 DNA polymerase alpha subunit p180 N terminal<br>PFAM-B_2966 (release 23.0). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00136, Pfam:PF08996, Pfam:PF03104. This family is the N terminal of DNA polymerase alpha subunit p180 protein. The N terminal contains the catalytic region of the alpha subunit.. 
+PF12255 Insecticide toxin TcdB middle/C-terminal region<br>PFAM-B_3032 (release 23.0). This domain family is found in bacteria, and is approximately 150 amino acids in length. The family is found in association with Pfam:PF03534. This family is the C-terminal-sided middle region of the bacterial insecticide toxin TcdB.. 
+PF12256 Insecticide toxin TcdB middle/N-terminal region<br>PFAM-B_3032 (release 23.0). This domain family is found in bacteria and archaea, and is typically between 164 and 180 amino acids in length. The family is found in association with Pfam:PF05593. This family is the N-terminal-sided middle region of the bacterial insecticide toxin TcdB. This region appears related to the FG-GAP repeat Pfam:PF01839.. 
+PF12257 Protein of unknown function (DUF3608)<br>PFAM-B_3083 (release 23.0). This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with Pfam:PF00610.. 
+PF12258 Microcephalin protein<br>PFAM-B_3105 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 384 and 835 amino acids in length. Microcephalin is involved in determining the size of the brain in animals. It is a protein, which if expressed homozygously causes the organism to have the condition microcephaly. Organisms expressing the mutated form of this protein in a homozygous manner develop a condition called microcephaly - a drastically reduced brain mass and volume. Microcephalin is predicted to contain three BRCA1 C-terminal domains, the first of which is the probable microcephaly mutation site.. 
+PF12259 Protein of unknown function (DUF3609)<br>PFAM-B_3173 (release 23.0). This domain family is found in eukaryotes and viruses, and is typically between 348 and 360 amino acids in length.. 
+PF12260 Protein-kinase domain of FAM69<br>Assefa S, Gavin OL, Coggill P. PFAM-B_3196 (release 23.0). This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localised to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.. 
+PF12261 Thermostable hemolysin<br>PFAM-B_3198 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 200 and 228 amino acids in length. T_hemolysin is a pore-forming toxin of bacteria, able to lyse erythrocytes from a number of mammalian species.. 
+PF12262 Bacterial virulence factor lipase N-terminal<br>PFAM-B_3205 (release 23.0). This domain family is found in bacteria, and is typically between 258 and 271 amino acids in length. There are two conserved sequence motifs: DGT and DGWST. This family is the N-terminal region of bacterial virulence factor lipase. The N-terminal region contains a potential signalling sequence.. 
+PF12263 Protein of unknown function (DUF3611)<br>PFAM-B_3207 (release 23.0). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 180 and 205 amino acids in length. There are two completely conserved residues (W and G) that may be functionally important.. 
+PF12264 VSL_protease; Peptidase_C03;<br>Waikavirus capsid protein 1. Assefa S, Gavin OL, Eberhardt R. PFAM-B_3208 (release 23.0). The rice tungro spherical waikavirus polyprotein is cleaved into 7 proteins, including three capsid proteins, by the tungro spherical virus-type peptidase Pfam:PF12381. This family represents the capsid protein 1 [1,2].. 
+PF12265 Histone-binding protein RBBP4 or subunit C of CAF1 complex<br>Pfam-B_318 (release 23.0). The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six  .. 
+PF12266 Protein of unknown function (DUF3613)<br>PFAM-B_3240 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 126 amino acids in length.. 
+PF12267 Protein of unknown function (DUF3614)<br>PFAM-B_3244 (release 23.0). This family of proteins is found in viruses. Proteins in this family are typically between 162 and 495 amino acids in length.. 
+PF12268 Protein of unknown function (DUF3612)<br>PFAM-B_3220 (release 23.0). This domain family is found in bacteria, and is approximately 180 amino acids in length. The family is found in association with Pfam:PF01381.. 
+PF12269 CpG binding protein zinc finger C terminal domain<br>PFAM-B_3253 (release 23.0). This domain family is found in eukaryotes, and is approximately 240 amino acids in length. This domain is the zinc finger domain of a CpG binding DNA methyltransferase protein. It contains a CxxC motif which forms the zinc finger and binds to DNA.. 
+PF12270 Cytochrome c oxidase subunit IV<br>PFAM-B_3280 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. This family is the fourth subunit of the cytochrome c oxidase complex. This subunit does not have a catalytic capacity but instead, is required for assembly and/or stability of the complex.. 
+PF12271 Chitin synthase III catalytic subunit<br>PFAM-B_3298 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 332 amino acids in length. This family is the catalytic domain of chitin synthase III. Chitin is a major component of fungal cell walls and this enzyme is responsible for its formation.. 
+PF12272 Protein of unknown function (DUF3610)<br>PFAM-B_3173 (release 23.0). This domain family is found in eukaryotes, and is typically between 146 and 160 amino acids in length. There are two conserved sequence motifs: FNN and IDS.. 
+PF12273 Chitin synthesis regulation, resistance to Congo red<br>Pfam-B_2935 (release 23.0). RCR proteins are ER membrane proteins that regulate chitin deposition in fungal cell walls. Although chitin, a linear polymer of beta-1,4-linked N-acetylglucosamine, constitutes only 2% of the cell wall it plays a vital role in the overall protection of the cell wall against stress, noxious chemicals and osmotic pressure changes. Congo red is a cell wall-disrupting benzidine-type dye extensively used in many cell wall mutant studies that specifically targets chitin in yeast cells and inhibits growth. RCR proteins render the yeasts resistant to Congo red by diminishing the content of chitin in the cell wall  . RCR proteins are probably regulating chitin synthase III interact directly with ubiquitin ligase Rsp5, and the VPEY motif is necessary for this, via interaction with the WW domains of Rsp5  .. 
+PF12274 Protein of unknown function (DUF3615)<br>PFAM-B_3306 (release 23.0). This domain family is found in bacteria and eukaryotes, and is typically between 86 and 97 amino acids in length. There is a conserved FAE sequence motif. There is a single completely conserved residue F that may be functionally important.. 
+PF12275 Protein of unknown function (DUF3616)<br>PFAM-B_3338 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 335 and 392 amino acids in length. There is a conserved GLRGPV sequence motif.. 
+PF12276 Protein of unknown function (DUF3617)<br>PFAM-B_3343 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 179 amino acids in length. There is a single completely conserved residue C that may be functionally important.. 
+PF12277 Protein of unknown function (DUF3618)<br>PFAM-B_3350 (release 23.0). This domain family is found in bacteria, and is approximately 50 amino acids in length.. 
+PF12278 Sex determination protein N terminal<br>PFAM-B_3366 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 410 amino acids in length. This family is the N terminal end of the sex determination protein of many different animals. It plays a role in the gender determination of around 20% of all animals.. 
+PF12279 Protein of unknown function (DUF3619)<br>PFAM-B_3353 (release 23.0). This protein is found in bacteria. Proteins in this family are about 140 amino acids in length. This protein has two conserved sequence motifs: AAR and DDLP.. 
+PF12280 Brain specific membrane anchored protein<br>PFAM-B_3398 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 285 and 331 amino acids in length. BSMAP has a putative transmembrane domain and is predicted to be a type I membrane glycoprotein.. 
+PF12281 Protein of unknown function (DUF3620)<br>PFAM-B_3384 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 281 and 358 amino acids in length. There are two completely conserved residues (G and P) that may be functionally important.. 
+PF12282 Signal transduction histidine kinase<br>PFAM-B_3401 (release 23.0). This domain is found in bacteria. This domain is about 150 amino acids in length. This domain is found associated with Pfam:PF07568, Pfam:PF08448, Pfam:PF02518. This domain has a single completely conserved residue P that may be functionally important. This family is mostly annotated as a histidine kinase involved in signal transduction but there is little published evidence to support this.. 
+PF12283 Bacteriophage protein K<br>PFAM-B_3455 (release 23.0). This family of proteins is found in viruses. Proteins in this family are approximately 60 amino acids in length. This family is a protein expressed by bacteriophages which has an unknown function. There is evidence that it is non-essential for in vivo production of a mature phage.. 
+PF12284 Hox protein A13 N terminal<br>PFAM-B_3464 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with Pfam:PF00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.. 
+PF12285 Protein of unknown function (DUF3621)<br>PFAM-B_3468 (release 23.0). This family of proteins is found in viruses. Proteins in this family are typically between 49 and 62 amino acids in length. There are two conserved sequence motifs: QPLDLS and EQQ.. 
+PF12286 Protein of unknown function (DUF3622)<br>PFAM-B_3490 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 72 and 107 amino acids in length. There is a conserved VSK sequence motif.. 
+PF12287 Cytoplasmic activation/proliferation-associated protein-1 C term<br>PFAM-B_3504 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteristic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.. 
+PF12288 Carboxysome shell peptide mid-region<br>PFAM-B_3507 (release 23.0). This domain family is found in bacteria and eukaryotes, and is approximately 430 amino acids in length. This family is annotated frequently as a carboxysome shell peptide, however there is little publication to confirm this.. 
+PF12289 Rotavirus VP1 structural protein<br>PFAM-B_3516 (release 23.0). This domain family is found in viruses, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF02123. VP1 is a structural protein of the inner core layer of the rotavirus virion. It complexes with VP2 and Vp3 to form this layer.. 
+PF12290 topoisom_IIA_B; Topoisom_IIA_B;<br>Protein of unknown function (DUF3802). PFAM-B_3547 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 143 amino acids in length. There is a conserved KNLFD sequence motif.. 
+PF12291 Protein of unknown function (DUF3623)<br>PFAM-B_3578 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 261 and 345 amino acids in length.. 
+PF12292 Protein of unknown function (DUF3624)<br>PFAM-B_3603 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved GRC sequence motif.. 
+PF12293 Protein of unknown function (DUF3625)<br>PFAM-B_3621 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 360 amino acids in length.. 
+PF12294 Protein of unknown function (DUF3626)<br>PFAM-B_3627 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 374 amino acids in length.. 
+PF12295 Symplekin tight junction protein C terminal<br>PFAM-B_3634 (release 23.0). This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a single completely conserved residue P that may be functionally important. Symplekn has been localized, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Careful analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited, partly but specifically, to the plaque structure of the zonula occludens. . 
+PF12296 Hydrophobic surface binding protein A<br>PFAM-B_3635 (release 23.0). This protein is found in eukaryotes. Proteins in this family are typically between 171 to 275 amino acids in length. Although the HsbA amino acid sequence suggests that HsbA may be hydrophilic, HsbA adsorbed to hydrophobic PBSA (Polybutylene succinate-co-adipate) surfaces in the presence of NaCl or CaCl2. When HsbA was adsorbed on the hydrophobic PBSA surfaces, it promoted PBSA degradation via the CutL1 polyesterase. CutL1 interacts directly with HsbA attached to the hydrophobic QCM electrode surface. These results suggest that when HsbA is adsorbed onto the PBSA surface, it recruits CutL1, and that when CutL1 is accumulated on the PBSA surface, it stimulates PBSA degradation.. 
+PF12297 Ellis van Creveld protein 2 like protein<br>PFAM-B_3668 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.. 
+PF12298 Eukaryotic mitochondrial regulator protein <br>PFAM-B_3672 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 381 amino acids in length. Bot1p localizes to the mitochondria in live cells and cofractionates with purified mitochondrial ribosomes. Bot1p has a novel function in the control of cell respiration by acting on the mitochondrial protein synthesis machinery. Observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms.. 
+PF12299 Protein of unknown function (DUF3627)<br>PFAM-B_3687 (release 23.0). This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF02498.. 
+PF12300 Protein of unknown function (DUF3628)<br>PFAM-B_3692 (release 23.0). This domain family is found in bacteria, and is typically between 153 and 183 amino acids in length. The family is found in association with Pfam:PF00270, Pfam:PF00271.. 
+PF12301 CD99 antigen like protein 2<br>PFAM-B_3714 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 165 and 237 amino acids in length. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum.. 
+PF12302 Protein of unknown function (DUF3629)<br>PFAM-B_3723 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 292 amino acids in length.. 
+PF12304 Beta-casein like protein<br>PFAM-B_3744 (release 23.0). This protein is found in eukaryotes. Proteins in this family are typically between 216 to 240 amino acids in length. This protein has two conserved sequence motifs: VLR and TRIY. BCLP is associated with cell morphology and a regulation of growth pattern of tumor. It is found in adenocarcinomas of uterine cervical tissues.. 
+PF12305 Protein of unknown function (DUF3630)<br>PFAM-B_3766 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue D that may be functionally important.. 
+PF12306 Inclusion body protein<br>PFAM-B_3786 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 191 amino acids in length. PixA is thought to be specifically produced in Xenorhabdus nematophila. It is an inclusion body protein.. 
+PF12307 Protein of unknown function (DUF3631)<br>PFAM-B_3787 (release 23.0). This protein is found in bacteria. Proteins in this family are typically between 180 to 701 amino acids in length.. 
+PF12308 Neurogenesis glycoprotein<br>PFAM-B_3817 (release 23.0). This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF02191. There are two conserved sequence motifs: SAQ and VQN. Noelin-1 is a glycoprotein which is secreted mainly by postmitotic neurogenic tissues in the developing central and peripheral nervous systems, first appearing after neural tube closure. It is likely that it forms large multimeric complexes.It has a divergent function in neurogenesis. In animal caps neuralized by expression of noggin, co-expression of Noelin-1 causes expression of neuronal differentiation markers several stages before neurogenesis normally occurs in this tissue. Finally, only secreted forms of the protein can activate sensory marker expression, while all forms of the protein can induce early neurogenesis.. 
+PF12309 KIF-1 binding protein C terminal<br>PFAM-B_3821 (release 23.0). This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 365 and 621 amino acids in length. There is a conserved LLP sequence motif. KBP is a binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a type of kinesin interacting protein.. 
+PF12310 Transcription factor protein N terminal<br>PFAM-B_3835 (release 23.0). This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.. 
+PF12311 Protein of unknown function (DUF3632)<br>PFAM-B_3839 (release 23.0). This domain family is found in eukaryotes, and is approximately 170 amino acids in length. There is a conserved ALE sequence motif.. 
+PF12312 NeA_polyprotein;<br>Nepovirus subgroup A polyprotein . PFAM-B_3843 (release 23.0). This family of proteins is found in viruses. Proteins in this family are typically between 259 and 1110 amino acids in length. The family is found in association with Pfam:PF03688, Pfam:PF03689, Pfam:PF03391. This family is one of the polyproteins expressed by Nepoviruses in subgroup A.. 
+PF12313 NPR1/NIM1 like defence protein C terminal<br>PFAM-B_3871 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with Pfam:PF00023, Pfam:PF00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.. 
+PF12314 Inner membrane complex protein<br>PFAM-B_3921 (release 23.0). This domain is found in bacteria and eukaryotes. This domain is about 120 amino acids in length. This family is the inner membrane complex of parasitic organisms. This is a cytoskeletal structure associated with the pellicle of these parasites.. 
+PF12315 Protein of unknown function (DUF3633)<br>PFAM-B_3949 (release 23.0). This domain family is found in bacteria and eukaryotes, and is approximately 210 amino acids in length. The family is found in association with Pfam:PF00412.. 
+PF12316 Segment polarity protein dishevelled (Dsh) C terminal<br>PFAM-B_3969 (release 23.0). This domain family is found in eukaryotes, and is typically between 177 and 207 amino acids in length. The family is found in association with Pfam:PF00778, Pfam:PF02377, Pfam:PF00610, Pfam:PF00595. The segment polarity gene dishevelled (dsh) is required for pattern formation of the embryonic segments. It is involved in the determination of body organisation through the Wingless pathway (analogous to the Wnt-1 pathway).. 
+PF12317 Intraflagellar transport complex B protein 46 C terminal<br>PFAM-B_3974 (release 23.0). This family of proteins is found in eukaryotes. Proteins in this family are typically between 298 and 416 amino acids in length. IFT46 is a flagellar protein of complex B. Like all IFT proteins, it is required for transport of IFT particles into the flagella.. 
+PF12318 Membrane bound FAD containing D-sorbitol dehydrogenase <br>PFAM-B_3647 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 168 and 189 amino acids in length. There is a conserved ALM sequence motif. This family is a membrane protein (FAD-SLDH) involved in oxidation of D-sorbitol to L-sorbose.. 
+PF12319 Tryptophan-Threonine-rich plasmodium antigen C terminal<br>PFAM-B_3676 (release 23.0). This protein is found in eukaryotes. Proteins in this family are typically between 254 to 536 amino acids in length. This family is the C terminal of a surface antigen of malarial Plasmodium species. It is currently being targeted for use as part of a subunit vaccine against Plasmodium falciparum, the main species involved in causing human malaria.. 
+PF12320 Type 5 capsule protein repressor C-terminal domain<br>PFAM-B_3790 (release 23.0). This domain is found in bacteria and archaea. This domain is about 90 amino acids in length. This domain is found associated with Pfam:PF00149. SbcD works in complex with SbdC (SbcDC) which is a transcription regulator. It down-regulates transcription of arl and mgr to inhibit type 5 capsule protein production. It acts as part of the SOS pathway of bacteria.. 
+PF12321 Protein of unknown function (DUF3634)<br>PFAM-B_3607 (release 23.0). This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.. 
+PF12322 T4 bacteriophage base plate protein<br>PFAM-B_3861 (release 23.0). This protein is found in viruses. Proteins in this family are typically between 208 to 249 amino acids in length. This protein has a single completely conserved residue S that may be functionally important. This family includes the two base plate proteins in T4 bacteriophages. These are gp51 and gp26, encoded by late genes.. 
+PF12323 HTH_14;<br>Helix-turn-helix domain. Pfam-B_1210 (release 3.0) & Pfam-B_4602 (Release 7.5). This is the N terminal helix-turn-helix domain of Transposase_2 Pfam:PF01385.. 
+PF12324 Helix-turn-helix domain of alkylmercury lyase<br>Pfam-B_3505 (release 6.5). Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. This is the N terminal helix-turn-helix domain associated with Pfam:PF03243.. 
+PF12325 TATA element modulatory factor 1 TATA binding<br>Pfam-B_97264 (release 23.0). This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes  . The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs  . TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal   and plant   cells. The Rab6-binding domain appears to be the same region as this C-terminal family  .. 
+PF12326 N-glycosylation protein<br>Pfam-B_29822 (release 23.0). This family is not required for survival of S.cerevisiae, but its deletion leads to heightened sensitivity to oxidative stress. It appears to be involved in N-glycosylation, and resides in the endoplasmic reticulum.. 
+PF12327 FtsZ family, C-terminal domain<br>This family includes the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ is a GTPase, like tubulin. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea.. 
+PF12328 Rpp20 subunit of nuclear RNase MRP and P<br>Pfam-B_33537 (release 23.0). The nuclear RNase P of Saccharomyces cerevisiae is made up of at least nine protein subunits; Pop1, Pop3, Pop4, Pop5, Pop6, Pop7, Pop8, Rpr2 and Rpp1. Many of these subunits seem to be present also in the RNase MRP, with the exception of Rpr2 (Rpp21) which is unique to RNase P. Human nuclear RNase P and MRP appear to contain at least 10 protein subunits, Rpp14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, Rpp40, hPop1 and hPop5, although there is recent evidence that not all of these subunits are shared between P and MRP. Archaeal RNase P has at least four protein subunits homologous to eukaryotic RNase P/MRP proteins  . In the yeast RNase P, Pop6 and Pop7 (the Rpp20 homologue) interact with each other and they are both interaction partners of Pop4  ; in the human MRP Rpp25 and Rpp20 interact with each other   and Rpp25 binds to Rpp29 (Pop4)  .. 
+PF12329 TATA element modulatory factor 1 DNA binding<br>This is the middle region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures. . The whole proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein.  TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal   and plant   cells.. 
+PF12330 Domain of unknown function (DUF3635)<br>This family may be a potential Haspin-related leucine-zipper. A leucine zipper was proposed to be present towards the C-terminus of human Haspin, (up-stream of the current family)  ; however, as this domain would appear to span several helices and be largely within a loop structure  , the actual zipper might be further downstream, and be this family, which is the very C-terminal part of the Sch. pombe sequence.. 
+PF12331 Protein of unknown function (DUF3636) <br>This domain family is found in eukaryotes, and is approximately 160 amino acids in length.. 
+PF12333 Rix1 complex component involved in 60S ribosome maturation<br>This domain family is found in eukaryotes, and is typically between 91 and 105 amino acids in length. This family is the N terminal of Ipi1, a component of the Rix1 complex which works in conjunction with Rea1 to mature the 60S ribosome.. 
+PF12334 Rickettsia outer membrane protein B <br>This domain family is found in bacteria, and is approximately 220 amino acids in length. The family is found in association with Pfam:PF03797. This family is the middle region of one of the outer membrane proteins of Rickettsia which is involved in adhesion to eukaryotic cells for uptake.. 
+PF12335 Myotubularin protein <br>This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with Pfam:PF02141, Pfam:PF03456, Pfam:PF03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.. 
+PF12336 SOX transcription factor<br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00505. There are two conserved sequence motifs: KKDK and LPG. This family is made up of SOX transcription factors. These are involved in upregulation of nestin, a neural promoter.. 
+PF12337 Protein of unknown function (DUF3637) <br>This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00073, Pfam:PF08935.. 
+PF12338 Ribulose-1,5-bisphosphate carboxylase small subunit<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00101. There is a conserved APF sequence motif. There are two completely conserved residues (L and P) that may be functionally important. This family is the small subunit of ribulose-1,5-bisphosphate.. 
+PF12339 DNA-J related protein <br>This domain family is found in bacteria, and is approximately 130 amino acids in length. The family is found in association with Pfam:PF00226. There is a conserved YYLD sequence motif. Mostof the sequences in this family are annotated as DNA-J related proteins but there is little publication to back this up.. 
+PF12340 Protein of unknown function (DUF3638)<br>This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There are two conserved sequence motifs: LLE and NMG.. 
+PF12341 Protein of unknown function (DUF3639) <br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00400. There are two completely conserved residues (E and R) that may be functionally important.. 
+PF12342 Protein of unknown function (DUF3640) <br>This family of proteins is found in viruses. Proteins in this family are typically between 25 and 211 amino acids in length.. 
+PF12343 Cold shock protein DEAD box A<br>This domain family is found in bacteria, and is typically between 68 and 89 amino acids in length. The family is found in association with Pfam:PF00270, Pfam:PF00271, Pfam:PF03880. This family is the C terminal region of DEAD box A, a protein expressed under conditions of cold shock which is involved in various cellular processes such as transcription, translation and DA recombination.. 
+PF12344 Ultra-violet resistance protein B<br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00271, Pfam:PF02151, Pfam:PF04851. There are two conserved sequence motifs: YAD and RRR. This family is the C terminal region of the UvrB protein which conveys mutational resistance against UV light to various different species.. 
+PF12345 Protein of unknown function (DUF3641) <br>This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF04055. This family consists of proteins which are commonly annotated as Radical SAM domains but there is little annotation to back this up.. 
+PF12346 HJURP_repeat;<br>Holliday junction recognition protein-associated repeat. Vertebral Holliday junction recognition proteins carry an SCM3 domain at their N-terminus as do the eukaryotic fungi, but they also carry this central, conserved region. The function of this family is not known. Further downstream there is also a repeated domain, also of unknown function. Investigation of Scm3 and associated proteins is likely to be directly relevant to understanding the mechanism of HJURP-mediated CENP-A chromatin assembly at human centromeres.. 
+PF12347 HJURP_repeat;<br>Holliday junction regulator protein family C-terminal repeat. Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, Pfam:PF10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.. 
+PF12348 CLASP N terminal<br>This region is found at the N terminal of CLIP-associated proteins (CLASPs).\.   CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules   .  In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present.  In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1  .. 
+PF12349 SREBP-CAP_SSD;<br>Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER  . Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini  . This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein  . WD40 domains are found towards the C-terminus.. 
+PF12350 CTD kinase subunit gamma CTK3 C-terminus<br>Pfam-B_12814 (release 23.0). The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation  . The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2  . It is not clear what independent function this C-terminal domain has.. 
+PF12351 Ca2+ regulator and membrane fusion protein Fig1<br>During the mating process of yeast cells, two Ca2+ influx pathways become activated. The resulting elevation of cytosolic free Ca2+ activates downstream signaling factors that promote long term survival of unmated cells.  Fig1 is a regulator of the low affinity Ca2+ influx system (LACS)  , and is also required for efficient membrane fusion during yeast mating  .. 
+PF12352 Snare region anchored in the vesicle membrane C-terminus<br>Within the SNARE proteins interactions in the C-terminal half of the SNARE helix are critical to the driving of membrane fusion; whereas interactions in the N-terminal half of the SNARE domain are important for promoting priming or docking of the vesicle Pfam:PF05008.. 
+PF12353 Eukaryotic translation initiation factor 3 subunit G <br>This domain family is found in eukaryotes, and is approximately 130 amino acids in length. The family is found in association with Pfam:PF00076. This family is subunit G of the eukaryotic translation initiation factor 3. Subunit G is required for eIF3 integrity.. 
+PF12354 Bacterial adhesion/invasion protein N terminal<br>This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00560, Pfam:PF08191, Pfam:PF09479. There are two completely conserved residues (I and F) that may be functionally important. Internalin mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. This family is the N terminal of internalin, the cap domain of the protein. The cap domain is conserved between different internalin types. The cap domain does not interact with E cadherin, therefore its function is presumably structural: capping the hydrophobic core.. 
+PF12355 Down syndrome cell adhesion molecule C terminal <br>This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00047, Pfam:PF07679, Pfam:PF00041. The Down syndrome cell adhesion molecule (Dscam) belongs to a family of cell membrane molecules involved in the differentiation of the nervous system. This is the C terminal cytoplasmic tail region of Dscam.. 
+PF12356 Protein of unknown function (DUF3643) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 217 and 4852 amino acids in length. There is a conserved TLA sequence motif.. 
+PF12357 Phospholipase D C terminal <br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00168, Pfam:PF00614. There is a conserved FPD sequence motif.  This family is the C terminal of phospholipase D. PLD is a major plant lipid-degrading enzyme which is involved in signal transduction.. 
+PF12358 Protein of unknown function (DUF3644) <br>This domain family is found in bacteria, and is typically between 65 and 80 amino acids in length.. 
+PF12359 Protein of unknown function (DUF3645) <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a conserved HPD sequence motif.. 
+PF12360 Paired box protein 7 <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00046, Pfam:PF00292.  Pax7 belongs to a family of genes that encode paired-box-containing transcription factors involved in the control of developmental processes. Pax7 has a distinct role in the specification of myogenic satellite cells.. 
+PF12361 Duffy-antigen binding protein <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 449 and 1061 amino acids in length. The family is found in association with Pfam:PF05424. There are two conserved sequence motifs: NKNGG and QKHDF. This family is part of the Duffy-antigen binding protein of Plasmodium spp. This protein is an antigen on these parasites which enable them to invade erythrocytes.. 
+PF12362 DNA polymerase III gamma and tau subunits C terminal<br>This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00004. The proteins in this family are frequently annotated as the gamma and tau subunits of DNA polymerase III, however there is little accompanying literature to back this up.. 
+PF12363 Phage protein <br>This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 119 and 164 amino acids in length. The proteins in this family are frequently annotated as phage proteins, however there is little accompanying literature to back this up or to describe the nature of these phage proteins.. 
+PF12364 Protein of unknown function (DUF3648) <br>This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 53 and 3115 amino acids in length. There are two completely conserved residues (A and F) that may be functionally important.. 
+PF12365 Protein of unknown function (DUF3649) <br>This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length.. 
+PF12366 Cancer susceptibility candidate 1 <br>This domain family is found in eukaryotes, and is typically between 216 and 263 amino acids in length. Casc1 has many SNPs associated with cancer susceptibility.. 
+PF12367 Pyruvate ferredoxin oxidoreductase beta subunit C terminal<br>This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF02775. There are two completely conserved residues (A and G) that may be functionally important. PFO is involved in carbon dioxide fixation via a reductive TCA cycle. It forms a heterodimer (alpha/beta). The beta subunit has binding motifs for Fe-S clusters and thiamine pyrophosphate.. 
+PF12368 Protein of unknown function (DUF3650) <br>This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00581. There is a single completely conserved residue N that may be functionally important.. 
+PF12369 Gonadotropin hormone receptor transmembrane region <br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00560, Pfam:PF00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.. 
+PF12371 Protein of unknown function (DUF3651)<br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. This family is frequently annotated as a membrane protein but there is little associated literature to back this up.. 
+PF12372 Huntingtin protein region <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.. 
+PF12373 Major surface glycoprotein 2 C terminal<br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF02349. This family is the C terminal of major surface glycoprotein 2 of virulent bacteria. It is a virulence factor antigen.. 
+PF12374 Double-sex mab3 related transcription factor 1<br>This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with Pfam:PF00751. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.. 
+PF12375 Phage protein<br>This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 112 and 194 amino acids in length.. 
+PF12376 Protein of unknown function (DUF3654) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 193 and 612 amino acids in length.. 
+PF12377 Duffy binding protein N terminal <br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF05424. This family contains the N terminus of the Duffy receptor binding domain.. 
+PF12378 Trypsin-sensitive surface-exposed protein<br>This domain family is found in bacteria, and is typically between 67 and 79 amino acids in length. This family contains trypsin-sensitive surface-exposed proteins called cytadhesins. Cytadhesins are virulence factor proteins which mediate attachment of bacterial cells to host cells for invasion.. 
+PF12379 Protein of unknown function (DUF3655) <br>This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF08716, Pfam:PF01661, Pfam:PF05409, Pfam:PF06471, Pfam:PF08717, Pfam:PF06478, Pfam:PF09401, Pfam:PF06460, Pfam:PF08715, Pfam:PF08710.. 
+PF12380 Gill-associated viral 3C-like peptidase<br>a positive-stranded RNA virus of prawns, that has been called yellow head virus protease and gill-associated virus 3C-like peptidase. The GAV cysteine protease is predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, pp1a and pp1ab. This protease employs a Cys(2968)-His(2879) catalytic dyad.. 
+PF12381 Tungro spherical virus-type peptidase<br>This is the protease for self-cleavage of the positive single-stranded polyproteins of a number of plant viral genomes. The protease activity of the polyprotein is at the C-terminal end, adjacent to the putative RNA polymerase.. 
+PF12382 Retrotransposon peptidase<br>This is a small family of fungal retroviral aspartyl peptidases.. 
+PF12383 Severe acute respiratory syndrome coronavirus 3b protein<br>This family of proteins is found in viruses. Proteins in this family are typically between 32 and 154 amino acids in length. This family contains the SARS coronavirus 3b protein which is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells.. 
+PF12384 Ty3 transposon peptidase<br>Ty3 is a gypsy-type, retrovirus-like, element found in the budding yeast. The Ty3 aspartyl protease is required for processing of the viral polyprotein into its mature species.. 
+PF12385 Papain-like cysteine protease AvrRpt2<br>This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis  . AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2  .. 
+PF12386 Pseudomurein endo-isopeptidase Pei<br>This peptidase has the catalytic triad C-H-D at the C-terminal end, a triad similar to that in thiol proteases and animal transglutaminases. It catalyses the in vitro lysis of M. marburgensis cells under reducing conditions and exhibits characteristics of metal-activated peptidases.. 
+PF12387 Pestivirus NS2 peptidase<br>The pestivirus NS2 peptidase is responsible for single cleavage between NS2 and NS3 of the bovine viral diarrhea virus polyprotein, a cleavage that is correlated with cytopathogenicity  . The peptidase is activated by its interaction with 'J-domain protein interacting with viral protein' - Jiv. [2, 1].. 
+PF12388 Dual-action HEIGH metallo-peptidase<br>The catalytic triad for this family of proteases is HE-H-H, which in many members is in the sequence motif HEIGH.. 
+PF12389 Camelysin metallo-endopeptidase<br>
+PF12390 Selenocysteine synthase N terminal<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF03841.  There is a single completely conserved residue P that may be functionally important. This family is the N terminal region of selenocysteine synthase which catalyses the conversion of seryl-tRNA(Sec) into selenocysteyl-tRNA(Sec).. 
+PF12391 Protocatechuate 3,4-dioxygenase beta subunit N terminal<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00775.  There are two completely conserved residues (Y and R) that may be functionally important. This family is the N terminal region of the beta subunit of protocatechuate 3,4-dioxidase. This enzyme utilizes a mononuclear, non-heme Fe3+ centre to catalyse metabolic cellular reactions.. 
+PF12392 Collagenase <br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF01136.. 
+PF12393 Dr family adhesin <br>This domain family is found in bacteria, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF04619. This family is the Dr-family adhesin expressed by uropathogenic E. coli.. 
+PF12394 Protein of unknown function (DUF3657) <br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF05057.. 
+PF12395 Protein of unknown function <br>This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF08874. There are two completely conserved residues (D and R) that may be functionally important.. 
+PF12396 Protein of unknown function (DUF3659) <br>This domain family is found in bacteria and eukaryotes, and is approximately 70 amino acids in length.. 
+PF12397 U3 small nucleolar RNA-associated protein 10 <br>This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF08146. This family is the protein associated with U3 snoRNA which is involved in the processing of pre-rRNA.. 
+PF12398 Receptor serine/threonine kinase <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00954, Pfam:PF01453, Pfam:PF00069, Pfam:PF08276. There is a conserved ELPL sequence motif.. 
+PF12399 Branched-chain amino acid ATP-binding cassette transporter<br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00005. There is a conserved AYLG sequence motif. This family is the C terminal of an ATP dependent branched-chain amino acid transporter.. 
+PF12400 Vaculolar membrane protein <br>This domain family is found in eukaryotes, and is typically between 123 and 138 amino acids in length.. 
+PF12401 Protein of unknown function (DUF2662) <br>This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00498.. 
+PF12402 NocA-like zinc-finger protein 1<br>This domain family is found in eukaryotes, and is typically between 42 and 57 amino acids in length. There is a conserved GAY sequence motif.  There is a single completely conserved residue G that may be functionally important. Nlz1 self-associated via its C terminus, interacted with Nlz2, and bound to histone deacetylases.. 
+PF12403 Paired-box protein 2 C terminal<br>This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.. 
+PF12404 Peptidase <br>This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00883. There is a conserved WAF sequence motif.. 
+PF12406 Surface protein <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 131 and 312 amino acids in length.. 
+PF12407 Homeobox protein <br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00046. This family is a homeobox protein involved in differentiation of embryonic cells to form the abdominal region.. 
+PF12408 Ribose-5-phosphate isomerase <br>This domain family is found in bacteria, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF02502. There are two completely conserved residues (D and F) that may be functionally important.. 
+PF12409 P_ATPase;<br>P5-type ATPase cation transporter. This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with Pfam:PF00122, Pfam:PF00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.. 
+PF12410 Poxvirus DNA dependent RNA polymerase 30kDa subunit <br>This family of proteins is found in viruses. Proteins in this family are typically between 193 and 259 amino acids in length. The family is found in association with Pfam:PF01096. There are two conserved sequence motifs: GIEYSKD and LRY. This family is N terminal of the 30 kDa subunit of poxvirus DNA-d-RNA-pol. It has structural similarity to the eukaryotic transcriptional elongation factor SII.. 
+PF12411 Choline sulfatase enzyme C terminal <br>This domain family is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00884. There are two completely conserved residues (R and W) that may be functionally important. This family is the C terminal of choline sulfatase, the enzyme responsible for catalysing the conversion of choline-O-sulfate and, at a lower rate, phosphorylcholine, into choline.. 
+PF12412 Protein of unknown function (DUF3667)<br>This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF12413 Homeobox protein distal-less-like N terminal <br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.. 
+PF12414 Calcitonin gene-related peptide regulator C terminal<br>This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with Pfam:PF00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.. 
+PF12415 Poxvirus DNA dependent RNA polymerase<br>This domain family is found in viruses, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF04566, Pfam:PF00562, Pfam:PF04567, Pfam:PF04560, Pfam:PF04565. This family is the second largest subunit of the poxvirus DNA dependent RNA polymerase. It has structural similarity to the second-largest RNA polymerase subunits of eubacteria, archaebacteria, and eukaryotes.. 
+PF12416 Cep120 protein<br>This family includes the Cep120 protein which is associated with centriole structure and function  .. 
+PF12417 Zinc finger protein <br>This domain family is found in eukaryotes, and is typically between 64 and 80 amino acids in length.. 
+PF12418 Acyl-CoA dehydrogenase N terminal <br>This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF02770, Pfam:PF00441, Pfam:PF02771. This family is one of the enzymes involved in AcylCoA interaction in beta-oxidation.. 
+PF12419 SNF2 Helicase protein <br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00271, Pfam:PF00176. Most of the proteins in this family are annotated as SNF2 helicases but there is little accompanying literature to confirm this.. 
+PF12420 Protein of unknown function <br>This domain family is found in eukaryotes, and is typically between 96 and 116 amino acids in length.. 
+PF12421 Fibronectin type III protein <br>This domain family is found in bacteria and viruses, and is typically between 126 and 146 amino acids in length. The family is found in association with Pfam:PF09327, Pfam:PF00041. There are two completely conserved G residues that may be functionally important. Many of the proteins in this family are annotated as fibronectin type III however there is little accompanying literature to confirm this.. 
+PF12422 Condensin II non structural maintenance of chromosomes subunit<br>This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.. 
+PF12423 Kinesin protein 1B<br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00225, Pfam:PF00498. KIF1B is an anterograde motor for transport of mitochondria in axons of neuronal cells.. 
+PF12424 Plasma membrane calcium transporter ATPase C terminal<br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00689, Pfam:PF00122, Pfam:PF00702, Pfam:PF00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.. 
+PF12425 Protein of unknown function (DUF3673) <br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length.. 
+PF12426 RNA dependent RNA polymerase<br>This domain family is found in viruses, and is approximately 40 amino acids in length. There is a conserved MFNLKF sequence motif. There are two completely conserved residues (E and P) that may be functionally important.. 
+PF12427 Branched-chain amino acid aminotransferase <br>This domain family is found in bacteria, and is typically between 23 and 35 amino acids in length. The family is found in association with Pfam:PF01063. There is a conserved TRT sequence motif.. 
+PF12428 Protein of unknown function (DUF3675) <br>This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00097. There are two completely conserved residues (R and L) that may be functionally important.. 
+PF12429 Protein of unknown function (DUF3676) <br>This domain family is found in eukaryotes, and is approximately 230 amino acids in length.. 
+PF12430 Abscisic acid G-protein coupled receptor <br>This domain family is found in eukaryotes, and is typically between 177 and 216 amino acids in length. This family is part of the abscisic acid (ABA) G-protein coupled receptor. ABA is a stress hormone in plants.. 
+PF12431 Transcriptional regulator <br>This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00072.  There is a single completely conserved residue G that may be functionally important. CitT is a transcriptional regulator which allows transcription of the citM gene which codes for the secondary transporter in the Mg-citrate transport complex.. 
+PF12432 Protein of unknown function (DUF3677) <br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length.. 
+PF12433 Parvovirus non-structural protein 1 <br>This family of proteins is found in viruses. Proteins in this family are typically between 109 and 668 amino acids in length. Parvoviral NSPs regulate host gene expression through histone acetylation.. 
+PF12434 Malate dehydrogenase enzyme <br>This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00390, Pfam:PF03949, Pfam:PF01515. There is a conserved AAL sequence motif.  There is a single completely conserved residue R that may be functionally important. Malate dehydrogenase is one of the enzymes involved in the citric acid cycle in mitochondria. It converts malate to oxaloacetate using NAD as a cofactor.. 
+PF12435 Protein of unknown function (DUF3678) <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length.. 
+PF12436 USP7;<br>ICP0-binding domain of Ubiquitin-specific protease 7. This domain is one of two C-terminal domains on the much longer ubiquitin-specific proteases. This particular one is found to interact with the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110.. 
+PF12437 Glutamine synthetase type III N terminal <br>This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. The family is found in association with Pfam:PF00120. This family is the N terminal region of glutamine synthetase type III which is one of the enzymes responsible for generation of glutamine through conversion glutamate to glutamine by the incorporation of ammonia (NH3).. 
+PF12438 Protein of unknown function (DUF3679) <br>This domain family is found in bacteria, and is approximately 60 amino acids in length.. 
+PF12439 Glycogen debranching enzyme N terminal<br>This domain family is found in bacteria and archaea, and is typically between 218 and 229 amino acids in length. The family is found in association with Pfam:PF06202. Glycogen debranching enzyme catalyses the debranching of amylopectin in glycogen. This is done by transferring three glucose subunits of glycogen from one parallel chain to another. This has the effect of enabling the glucose residues to become more accessible for glycolysis.. 
+PF12440 Melanoma associated antigen family N terminal <br>This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with Pfam:PF01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognised by cytotoxic T lymphocytes (CTLs).. 
+PF12441 Protein of unknown function (DUF3680) <br>This domain family is found in bacteria and archaea, and is approximately 40 amino acids in length.. 
+PF12442 Protein of unknown function (DUF3681) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 212 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF12443 AT-hook-containing transcription factor<br>This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.. 
+PF12444 Sox developmental protein N terminal <br>This domain family is found in eukaryotes, and is typically between 69 and 88 amino acids in length. The family is found in association with Pfam:PF00505. There are two conserved sequence motifs: YDW and PVR. This family contains Sox8, Sox9 and Sox10 proteins which have structural similarity. Sox proteins are involved in developmental processes.. 
+PF12445 Flagellin protein <br>This domain family is found in bacteria, and is typically between 125 and 147 amino acids in length. The family is found in association with Pfam:PF00669, Pfam:PF00700. There are two completely conserved G residues that may be functionally important. This family is the flagellin motor protein which confers motility to bacterial cells.. 
+PF12446 Protein of unknown function (DUF3682)<br>This domain family is found in eukaryotes, and is typically between 125 and 136 amino acids in length.. 
+PF12447 Protein of unknown function (DUF3683)<br>This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF02754, Pfam:PF01565, Pfam:PF02913.. 
+PF12448 Kinesin associated protein<br>This domain family is found in eukaryotes, and is typically between 143 and 173 amino acids in length. The family is found in association with Pfam:PF04849. This family is a region of the protein milton. Milton recruits the heavy chain of kinesin to mitochondria to allow the motor movement function of kinesin.. 
+PF12449 Protein of unknown function (DUF3684) <br>This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.. 
+PF12450 von Willebrand factor <br>This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00092. There are two conserved sequence motifs: STF and DVD.  There are two completely conserved residues (E and N) that may be functionally important. In hemostasis, platelet adhesion to the damaged vessel wall is mediated by several proteins, including von Willebrand factor. In solution vWF becomes immobilized via its A3 domain on the fibrillar collagen of the vessel wall and acts as an intermediary between collagen and the platelet receptor glycoprotein Ibalpha (GPIbalpha), which is the only platelet receptor that does not require prior activation for bond formation.. 
+PF12451 Vacuolar protein sorting protein 11 C terminal<br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length. Vps 11 is one of the evolutionarily conserved class C vacuolar protein sorting genes (c-vps: vps11, vps16, vps18, and vps33), whose products physically associate to form the c-vps protein complex required for vesicle docking and fusion.. 
+PF12452 Protein of unknown function (DUF3685) <br>This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important.. 
+PF12453 Protein tyrosine phosphatase N terminal <br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00041. There is a single completely conserved residue L that may be functionally important. This family consists of various protein tyrosine phosphatase haematopoietic receptors, e.g. CD45, which dephosphorylate growth stimulating proteins. This limits growth signalling in haematopoietic cells.. 
+PF12454 GPI-anchored cell wall organization protein<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. Ecm33 is an essential cell wall component and is important for cell wall integrity.. 
+PF12455 Dynein associated protein <br>This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with Pfam:PF01302. There is a single completely conserved residue E that may be functionally important. Dynactin has been associated with Dynein, a kinesin protein which is involved in organelle transport, mitotic spindle assembly and chromosome segregation. Dynactin anchors Dynein to specific subcellular structures.. 
+PF12456 Inositol phosphatase <br>This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.. 
+PF12457 Tuftelin interacting protein N terminal <br>This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with Pfam:PF08697, Pfam:PF01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralisation of enamel - tuftelin.. 
+PF12458 ATPase involved in DNA repair <br>This domain family is found in bacteria, and is approximately 450 amino acids in length. There are two conserved sequence motifs: DVF and SPNGED.. 
+PF12459 D-Ala-teichoic acid biosynthesis protein<br>This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (L and Y) that may be functionally important.. 
+PF12460 MMS19_N;<br>RNAPII transcription regulator C-terminal. MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription  . This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly  . This domain apparently shares homology with some HEAT repeat sequences.. 
+PF12461 Protein of unknown function (DUF3688) <br>This domain family is found in bacteria and viruses, and is typically between 79 and 104 amino acids in length. There is a conserved YRW sequence motif. There is a single completely conserved residue Y that may be functionally important.. 
+PF12462 Nucleolin_N;<br>DNA helicase IV / RNA helicase N terminal. This domain family is found in bacteria, and is approximately 170 amino acids in length. This family is found in bacterial DNA helicase IV, at the N-terminus of Pfam:PF00580.. 
+PF12463 Protein of unknown function (DUF3689) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 399 and 797 amino acids in length.. 
+PF12464 Maltose acetyltransferase <br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00132. Mac uses acetyl-CoA as acetyl donor to acetylated cytoplasmic maltose.. 
+PF12465 Proteasome beta subunits C terminal <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00227. There is a conserved GTT sequence motif. There is a single completely conserved residue Y that may be functionally important. This family includes the C terminal of the beta-type subunits of the proteasome, a multimeric complex that degrades proteins into peptides as part of the MHC class I-mediated Ag-presenting pathway.. 
+PF12466 Glutamate dehydrogenase N terminal<br>This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF05088.  There is a conserved ALR sequence motif. Glutamate dehydrogenase (GDH) is a homohexameric, mitochondrial enzyme that reversibly catalyses the oxidative deamination of L-glutamate to 2-oxoglutarate using either NADP(H) or NAD(H) with comparable efficacy.. 
+PF12467 Cucumber mosaic virus 1a protein family<br>This domain family is found in viruses, and is typically between 156 and 171 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01660. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein.. 
+PF12468 Type III secretion system leucine rich repeat protein  <br>This domain family is found in bacteria, and is approximately 50 amino acids in length. There are two completely conserved residues (Y and W) that may be functionally important. This family consists of leucine-rich repeat proteins involved in type III secretion.. 
+PF12469 CRISPR-associated protein <br>This domain family is found in bacteria and archaea, and is typically between 101 and 138 amino acids in length. The proteins in this family are frequently annotated as CRISPR-associated proteins however there is little accompanying literature to confirm this.. 
+PF12470 Suppressor of Fused Gli/Ci N terminal binding domain<br>This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with Pfam:PF05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologues. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologues.. 
+PF12471 GTP cyclohydrolase N terminal <br>This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. This family is the N terminal of GTP cyclohydrolase, the rate limiting enzyme in the synthesis of tetrahydrobiopterin.. 
+PF12472 Phage related protein<br>This domain family is found in bacteria and viruses, and is approximately 60 amino acids in length.. 
+PF12473 Kinesin protein <br>This domain family is found in eukaryotes, and is typically between 131 and 151 amino acids in length. The family is found in association with Pfam:PF00225, Pfam:PF00498. There is a single completely conserved residue W that may be functionally important.. 
+PF12474 Polo kinase kinase <br>This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.. 
+PF12475 Amdovirus non-structural protein <br>This domain family is found in viruses, and is approximately 50 amino acids in length. This family contains proteins of each of the four types of Amdovirus non-structural protein.. 
+PF12476 Protein of unknown function (DUF3696)<br>This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length.. 
+PF12477 Sex factor F TraW protein N terminal<br>This domain family is found in bacteria, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. The traW gene of the E. coli K-12 sex factor, F, encodes one of the numerous proteins required for conjugative transfer of this plasmid.. 
+PF12478 Ubiquitin-associated protein 2 <br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00627. There are two conserved sequence motifs: AVEMPG and QFG.. 
+PF12479 Protein of unknown function (DUF3698) <br>This domain family is found in eukaryotes, and is typically between 89 and 105 amino acids in length.. 
+PF12480 Protein of unknown function (DUF3699) <br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length.. 
+PF12481 Aluminium induced protein <br>This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: YGL and LRDR. This family is related to GATase enzyme domains.. 
+PF12482 Phage integrase protein<br>This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00589.. 
+PF12483 E3 Ubiquitin ligase<br>This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.. 
+PF12484 Polymorphic PE/PPE proteins C terminal<br>This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00823.  There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.. 
+PF12485 Lymphocyte signaling adaptor protein<br>This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with Pfam:PF07647, Pfam:PF07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.. 
+PF12486 ImpA domain protein <br>This family of proteins is found in bacteria. Proteins in this family are typically between 207 and 469 amino acids in length. The family is found in association with Pfam:PF06812.. 
+PF12487 Protein of unknown function (DUF3703) <br>This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length.. 
+PF12488 Protein of unknown function (DUF3704) <br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length.. 
+PF12489 Nuclear coactivator<br>This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.. 
+PF12490 Breast carcinoma amplified sequence 3 <br>This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.. 
+PF12491 Apolipoprotein B100 C terminal<br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length. There are two conserved sequence motifs: QLS and LIDL. ApoB100 has an essential role in the assembly and secretion of triglyceride-rich lipoproteins and lipids transport.. 
+PF12493 Protein of unknown function (DUF3709)<br>This domain family is found in bacteria, and is approximately 30 amino acids in length. There are two conserved sequence motifs: RCLMK and LIEL.. 
+PF12494 Protein of unknown function (DUF3695) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 157 and 192 amino acids in length. There is a single completely conserved residue D that may be functionally important.. 
+PF12495 Vegetative insecticide protein 3A N terminal <br>This family of proteins is found in bacteria. Proteins in this family are typically between 170 and 789 amino acids in length. The family is found in association with Pfam:PF02018. Vip3A represents a novel class of proteins insecticidal to lepidopteran insect larvae.. 
+PF12496 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2<br>This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.. 
+PF12497 Estrogen receptor beta<br>This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00104, Pfam:PF00105. There is a conserved IPS sequence motif.  There are two completely conserved residues (Y and W) that may be functionally important. ERbeta binds estrogens with an affinity similar to that of ERalpha, and activates expression of reporter genes containing estrogen response elements in an estrogen-dependent manner. ERbeta acts as a transcription factor once bound to its ligand and it can dimerise with ERalpha.. 
+PF12498 Basic leucine-zipper C terminal<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 174 and 411 amino acids in length. The family is found in association with Pfam:PF00170. There is a conserved KVK sequence motif. There is a single completely conserved residue K that may be functionally important. Various bZIP proteins have been found and shown to play a role in seed-specific gene expression. bZIP binds to the alpha-globulin gene promoter, but not to promoters of other major storage genes such as glutelin, prolamin and albumin.. 
+PF12499 Pherophorin <br>This domain family is found in eukaryotes, and is typically between 147 and 160 amino acids in length. The proteins in this family are frequently annotated as pherophorins however there is little accompanying literature to confirm this.. 
+PF12500 DUF3706;<br>TRSP domain C terminus to PRTase_2 . Anantharaman V, Gavin OL. This domain occurs C terminus to PRTase_2 and has a highly conserved GXXE and TRSP signatures  . It is found in bacteria.  These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response  .. 
+PF12501 Phosphate ATP-binding cassette transporter<br>This domain family is found in bacteria, and is typically between 143 and 173 amino acids in length. The family is found in association with Pfam:PF00528. There is a single completely conserved residue P that may be functionally important.. 
+PF12502 Protein of unknown function (DUF3710) <br>This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 284 amino acids in length. There are two conserved sequence motifs: DLG and DGPRW.. 
+PF12503 Cucumber mosaic virus 1a protein C terminal <br>This domain family is found in viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01660. There is a conserved GLG sequence motif. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein.. 
+PF12505 Protein of unknown function (DUF3712)<br>This domain family is found in eukaryotes, and is approximately 130 amino acids in length.. 
+PF12506 Protein of unknown function (DUF3713)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 92 and 1225 amino acids in length. There is a single completely conserved residue S that may be functionally important.. 
+PF12507 Human Cytomegalovirus UL139 protein<br>This family of proteins is found in eukaryotes and viruses. Proteins in this family are approximately 140 amino acids in length. UL139 product shared sequence homology with human CD24, a signal transducer modulating B-cell activation responses, and the sequences in the G1c variant of UL139 contained a specific attachment site of prokaryotic membrane lipoprotein lipid.. 
+PF12508 Protein of unknown function (DUF3714) <br>This domain family is found in bacteria, and is approximately 200 amino acids in length.. 
+PF12509 Protein of unknown function (DUF3715)<br>This domain family is found in eukaryotes, and is approximately 170 amino acids in length.. 
+PF12510 Smoothelin cytoskeleton protein<br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.. 
+PF12511 Protein of unknown function (DUF3716) <br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length.. 
+PF12512 Protein of unknown function (DUF3717) <br>This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 117 amino acids in length. There is a conserved AIN sequence motif. There are two completely conserved residues (L and Y) that may be functionally important.. 
+PF12513 Mitochondrial degradasome RNA helicase subunit C terminal<br>This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.. 
+PF12514 Protein of unknown function (DUF3718)<br>This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important. . 
+PF12515 Ca2+-ATPase N terminal autoinhibitory domain<br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00689, Pfam:PF00122, Pfam:PF00702, Pfam:PF00690. There is a conserved RRFR sequence motif. There are two completely conserved residues (F and W) that may be functionally important. This family is the N terminal autoinhibitory domain of an endosomal Ca2+-ATPase.. 
+PF12516 Protein of unknown function (DUF3719)<br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important.. 
+PF12517 Protein of unknown function (DUF3720) <br>This domain family is found in eukaryotes, and is approximately 100 amino acids in length. There are two completely conserved A residues that may be functionally important.. 
+PF12518 Protein of unknown function<br>This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. There is a conserved WMPC sequence motif. There are two completely conserved residues (A and C) that may be functionally important.. 
+PF12519 Protein of unknown function (DUF3722) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 415 and 473 amino acids in length.. 
+PF12520 Protein of unknown function (DUF3723) <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.. 
+PF12521 Protein of unknown function (DUF3724) <br>This domain family is found in viruses, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF00073. There is a single completely conserved residue Y that may be functionally important.. 
+PF12522 Cytomegalovirus glycoprotein N terminal<br>This domain family is found in viruses, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF03554. This family is an envelope glycoprotein of human cytomegalovirus (HCMV).. 
+PF12523 Protein of unknown function (DUF3725)<br>This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01577. There is a conserved FLE sequence motif.. 
+PF12524 dsDNA virus glycoprotein L C terminal <br>This domain family is found in viruses, and is typically between 55 and 80 amino acids in length. The family is found in association with Pfam:PF05259. This family is the C terminal of glycoprotein L from various types of double stranded DNA viruses (dsDNA).. 
+PF12525 Protein of unknown function (DUF3726) <br>This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF12526 Protein of unknown function (DUF3729) <br>This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01661, Pfam:PF05417, Pfam:PF01660, Pfam:PF00978. There is a single completely conserved residue L that may be functionally important.. 
+PF12527 Protein of unknown function (DUF3727) <br>This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length.. 
+PF12528 Prepilin peptidase dependent protein C (DUF3728)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 106 and 121 amino acids in length. The family is found in association with Pfam:PF07963. There are two completely conserved C residues that may be functionally important. This family is frequently annotated as prepilin peptidase dependent protein C.. 
+PF12529 Xylosyltransferase C terminal <br>This domain family is found in eukaryotes, and is typically between 169 and 183 amino acids in length. The family is found in association with Pfam:PF02485. There is a single completely conserved residue G that may be functionally important. Xylosyltransferases are enzymes involved in the biosynthesis of the glycosaminoglycan linker region in proteoglycans.. 
+PF12530 Protein of unknown function (DUF3730) <br>This domain family is found in eukaryotes, and is typically between 220 and 262 amino acids in length.. 
+PF12531 DNA-K related protein <br>This domain family is found in bacteria, and is approximately 250 amino acids in length. There are two conserved sequence motifs: RPG and WRR. The proteins in this family are frequently annotated as DNA-K related proteins however there is little accompanying literature to confirm this.. 
+PF12532 Protein of unknown function (DUF3732)<br>This domain family is found in bacteria and eukaryotes, and is typically between 180 and 198 amino acids in length. There is a conserved DQP sequence motif.. 
+PF12533 Neuronal helix-loop-helix transcription factor <br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to Pfam:PF00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.. 
+PF12534 Leucine-rich repeat containing protein 8 <br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00560. There are two completely conserved residues (W and Y) that may be functionally important. Many of the proteins in this family are annotated as leucine-rich repeat containing protein 8 however there is little accompanying literature to back this up.. 
+PF12535 Hydrolase of X-linked nucleoside diphosphate N terminal <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 847 and 5344 amino acids in length. These enzymes hydrolyse the molecular motif of a nucleoside diphosphate linked to some other moiety, X.. 
+PF12536 Patatin phospholipase <br>This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF01734. There are two completely conserved residues (F and G) that may be functionally important. The proteins in this family are frequently annotated as patatin family phospholipases however there is little accompanying literature to confirm this.. 
+PF12537 Protein of unknown function (DUF3735)<br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved LSG sequence motif. There is a single completely conserved residue G that may be functionally important.. 
+PF12538 DNA transporter <br>This domain family is found in bacteria, and is typically between 107 and 121 amino acids in length. The family is found in association with Pfam:PF01580. The FtsK/SpoIIIE family of DNA transporters are responsible for translocating missegregated chromosomes after the completion of cell division.. 
+PF12539 Chromosome segregation protein Csm1/Pcs1<br>Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis  .  Csm1 also plays a mitotic role in DNA replication  .  This family also contains the Schizosaccharomyces pombe homologue to Csm1, Pcs1.  Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together  .  The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment  .. 
+PF12540 Protein of unknown function (DUF3736)<br>This domain family is found in eukaryotes, and is typically between 135 and 160 amino acids in length.. 
+PF12541 Protein of unknown function (DUF3737) <br>This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 281 and 297 amino acids in length.. 
+PF12542 Pre-mRNA splicing factor<br>This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.. 
+PF12543 Protein of unknown function (DUF3738)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 457 amino acids in length.. 
+PF12544 Lysine-2,3-aminomutase <br>This domain family is found in bacteria, archaea and eukaryotes, and is typically between 111 and 127 amino acids in length. The family is found in association with Pfam:PF04055. LAM catalyses the interconversion of L-alpha-lysine and L-beta-lysine, which proceeds by migration of the amino group from C2 to C3 concomitant with cross-migration of the 3-pro-R hydrogen of L-alpha-lysine to the 2-pro-R position of L-beta-lysine.. 
+PF12545 Filamentous haemagglutinin family outer membrane protein<br>This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF05860.. 
+PF12546 Blue/Ultraviolet sensing protein C terminal<br>This domain family is found in eukaryotes, and is typically between 113 and 125 amino acids in length. The family is found in association with Pfam:PF03441, Pfam:PF00875. Cryptochromes are blue/ultraviolet-A light sensing photoreceptors involved in regulating various growth and developmental responses in plants.. 
+PF12547 Capicua transcriptional repressor modulator <br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 49 and 781 amino acids in length. There is a conserved IQT sequence motif. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells. The polyglutamine expanded mutant type of ATXN-1 does not bind Capicua with as high affinity as wild-type ATXN-1. It is associated with spinocerebellar ataxia type 1 (SCA1).. 
+PF12548 Sulfatase protein<br>This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with Pfam:PF00884.. 
+PF12549 Tyrosine hydroxylase N terminal <br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. Tyrosine hydroxylase converts L-tyrosine to L-DOPA in the catecholamine synthesis pathway.. 
+PF12550 Transcriptional activator of glycolytic enzymes<br>This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.. 
+PF12551 Poly-beta-hydroxybutyrate polymerase N terminal<br>This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF07167, Pfam:PF00561. There is a single completely conserved residue W that may be functionally important. PHBC is the third enzyme of the poly-beta-hydroxybutyrate biosynthetic pathway.. 
+PF12552 Protein of unknown function (DUF3741)<br>This domain family is found in eukaryotes, and is approximately 50 amino acids in length.. 
+PF12553 Protein of unknown function (DUF3742)<br>This domain family is found in bacteria, and is approximately 50 amino acids in length. There is a single completely conserved residue Y that may be functionally important.. 
+PF12554 DUF3743;<br>Mitotic-spindle organizing gamma-tubulin ring associated. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes  .. 
+PF12555 Thiamine pyrophosphokinase C terminal<br>This domain family is found in bacteria, and is approximately 50 amino acids in length. The proteins in this family catalyses the pyrophosphorylation of thiamine in yeast and synthesizes thiamine pyrophosphate (TPP), a thiamine coenzyme.. 
+PF12556 Cobaltochelatase CobS subunit N terminal <br>This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF07728.  There are two completely conserved residues (P and F) that may be functionally important. This family is the N terminal of the CobS subunit of cobaltochelatase. Cobaltochelatase belongs to the AAA+ superfamily of proteins. CobS and CobT form a chaperone like complex.. 
+PF12557 Cob(I)alamin adenosyltransferase N terminal <br>This domain family is found in bacteria and eukaryotes, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF02572. Cob(I)alamin adenosyltransferase adenosylates Co(I) in an ATP-dependent manner in the conversion of aquacobalamin to its coenzyme form. This is the third step in this process, after two steps involved in the reduction of Co(III) to Co(I).. 
+PF12558 ATP-binding cassette cobalt transporter<br>This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00005.  There is a conserved REP sequence motif. There is a single completely conserved residue P that may be functionally important. The proteins in this family are frequently annotated as ABC Cobalt transporters however there is little accompanying literature to confirm this.. 
+PF12559 Serine endopeptidase inhibitors<br>This family includes both microviridins and marinostatins. It seems likely that in both cases it is the C-terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. it is the ester linkages within the key, 12-residue. region that circularise the molecule giving it its inhibitory conformation [1, 2, 3].. 
+PF12560 Protein of unknown function (DUF3745)<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00097, Pfam:PF10426.. 
+PF12561 ToxR activated gene A lipoprotein<br>This domain family is found in bacteria, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF10462. There is a conserved GAG sequence motif. This family is a bacterial lipoprotein.. 
+PF12562 Protein of unknown function (DUF3746)<br>This domain family is found in viruses, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF04595.. 
+PF12563 Hemolytic toxin N terminal<br>This domain family is found in bacteria, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF07968, Pfam:PF00652. This family is a bacterial virulence factor - hemolysin - which forms pores in erythrocytes and causes them to lyse.. 
+PF12564 Type III restriction/modification enzyme methylation subunit<br>This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF01555.  There are two completely conserved residues (F and S) that may be functionally important. This family is a bacterial phage resistance protein. It functions in a type III restriction/modification enzyme complex. It is part of the methylation subunit of the complex. It binds DNA and methylates it.. 
+PF12565 Protein of unknown function (DUF3747)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 215 and 413 amino acids in length. There is a conserved DSNGYS sequence motif.. 
+PF12566 Protein of unknown function (DUF3748)<br>This domain family is found in bacteria and eukaryotes, and is approximately 120 amino acids in length.. 
+PF12567 Leukocyte receptor CD45<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 77 and 1130 amino acids in length. The family is found in association with Pfam:PF00041. CD45 plays a critical role in T-cell receptor (TCR)-mediated signaling. CD45 interacts with SKAP55 which is a transcriptional activator of IL-2.. 
+PF12568 Acetyltransferase (GNAT) domain<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. The proteins in this family are acetyltransferases of the GNAT family.. 
+PF12569 NMDA receptor-regulated protein 1 <br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF07719, Pfam:PF00515. There is a single completely conserved residue L that may be functionally important. NARP1 is the mammalian homologue of a yeast N-terminal acetyltransferase that regulates entry into the G(0) phase of the cell cycle.. 
+PF12570 Protein of unknown function (DUF3750)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 175 and 265 amino acids in length.. 
+PF12571 Phage tail-collar fibre protein<br>This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two completely conserved residues (K and W) that may be functionally important. The members are annotated as being putative phage tail or tail-collar proteins.. 
+PF12572 Protein of unknown function (DUF3752)<br>This domain family is found in eukaryotes, and is typically between 140 and 163 amino acids in length.. 
+PF12573 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00676.  There are two conserved sequence motifs: VPEP and RPG. This family is the alpha subunit of the E1 component of 2-oxoisovalerate dehydrogenase. This is the enzyme complex responsible for metabolism of pyruvate, 2-oxoglutarate, branched chain 2-oxo acids and acetoin. The E1 component is a heterotetramer of alpha2beta2. The homodimerised beta subunits are flanked by two alpha subunits in a 'vise' structure.. 
+PF12574 120 KDa Rickettsia surface antigen<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. This family is a Rickettsia surface antigen of 120 KDa which may be used as an antigen for immune response against the bacterial species.. 
+PF12575 Protein of unknown function (DUF3753)<br>This family of proteins is found in viruses. Proteins in this family are approximately 70 amino acids in length. There is a conserved YLK sequence motif. There are two completely conserved residues (D and F) that may be functionally important.. 
+PF12576 Protein of unknown function (DUF3754)<br>This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF12577 PPAR gamma N-terminal region<br>Peroxisome proliferator-activated receptors (PPAR) are nuclear hormone receptors that control the expression of genes involved in lipid homeostasis in mammals.  This sequence region is found at the N-terminus of these proteins. The family is found in association with Pfam:PF00104, Pfam:PF00105. It is not clear if this region is a separate protein domain.. 
+PF12578 Myotubularin-associated protein<br>This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.. 
+PF12579 Protein of unknown function (DUF3755)<br>This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a single completely conserved residue N that may be functionally important.. 
+PF12580 Tripeptidyl peptidase II <br>This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.. 
+PF12581 Protein of unknown function (DUF3756)<br>This domain family is found in viruses, and is approximately 40 amino acids in length.. 
+PF12582 Protein of unknown function (DUF3757)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 154 amino acids in length.. 
+PF12583 Tripeptidyl peptidase II N terminal<br>This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.. 
+PF12584 DUF3758;<br>Trafficking protein particle complex subunit 10, TRAPPC10. This domain forms part of the TRAPP complex for mediating vesicle docking and fusion in the Golgi apparatus. The fungal version is referred to as Trs130, and an alternative vertebrate alias is TMEM1 [1,2].. 
+PF12585 Protein of unknown function (DUF3759)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 107 and 132 amino acids in length. There is a single completely conserved residue H that may be functionally important.. 
+PF12586 Protein of unknown function (DUF3760)<br>This domain family is found in eukaryotes, and is typically between 46 and 64 amino acids in length.. 
+PF12587 Protein of unknown function (DUF3761)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 157 amino acids in length.. 
+PF12588 Phophatidylserine decarboxylase <br>This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF02666. Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes.. 
+PF12589 Methyltransferase involved in Williams-Beuren syndrome<br>This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with Pfam:PF08241. This family is made up of S-adenosylmethionine-dependent methyltransferases  . The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype  .. 
+PF12590 Acyl-ATP thioesterase<br>This domain family is found in bacteria and eukaryotes, and is typically between 120 and 131 amino acids in length. The family is found in association with Pfam:PF01643. The plant acyl-acyl carrier protein (ACP) thioesterases (TEs) have roles in fatty acid synthesis.. 
+PF12591 Protein of unknown function (DUF3762)<br>This domain family is found in viruses, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF05533.. 
+PF12592 Protein of unknown function (DUF3763)<br>This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF07728. There is a single completely conserved residue F that may be functionally important.. 
+PF12593 Microcystin synthetase C terminal<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF08242, Pfam:PF00501. There is a conserved YAN sequence motif. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases. This family is made up of the C terminal of microcystin synthetase, one of the proteins involved in this synthesis pathway.. 
+PF12594 Protein of unknown function (DUF3764)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 89 and 101 amino acids in length.. 
+PF12595 Rhomboid serine protease<br>This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with Pfam:PF01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.. 
+PF12596 87kDa_TransP;<br>This domain family is found in eukaryotes, and is typically between 78 and 110 amino acids in length. The family is found in association with Pfam:PF05485. There are two completely conserved residues (D and G) that may be functionally important. This family is an 87kDa transposase protein which catalyses both the precise and imprecise excision of a nonautonomous P transposable element.. 
+PF12597 Protein of unknown function (DUF3767)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 199 amino acids in length.. 
+PF12598 T-box transcription factor<br>This domain family is found in eukaryotes, and is typically between 77 and 89 amino acids in length. The family is found in association with Pfam:PF00907. There are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates. 
+PF12599 Protein of unknown function (DUF3768)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 108 and 129 amino acids in length. There are two conserved sequence motifs: NDP and RVLT.. 
+PF12600 Protein of unknown function (DUF3769)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 560 and 931 amino acids in length.. 
+PF12601 Rubivirus non-structural protein<br>This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF05407. The rubella virus (RUB) nonstructural (NS) protein (NSP) ORF encodes a protease that cleaves the NSP precursor (240 kDa) at a single site to produce two products.. 
+PF12602 Fertility inhibition protein N terminal<br>This domain family is found in bacteria, and is typically between 62 and 102 amino acids in length. The family is found in association with Pfam:PF04352. The FinOP (fertility inhibition) system of F-like plasmids consists of an antisense RNA (FinP) and a 22 kDa protein (FinO) which act in concert to prevent the translation of TraJ, the positive regulator of the transfer operon.. 
+PF12603 Protein of unknown function (DUF3770)<br>This domain family is found in viruses, and is approximately 250 amino acids in length. The family is found in association with Pfam:PF04196.. 
+PF12604 Tail fiber protein gp37 C terminal<br>This domain family is found in bacteria and viruses, and is typically between 49 and 166 amino acids in length. The family is found in association with Pfam:PF03906. In T-even phages, gp37 and gp38 are components of the tail fiber that are critical for phage-host interaction.. 
+PF12605 Casein kinase 1 gamma C terminal<br>This domain family is found in eukaryotes, and is typically between 54 and 99 amino acids in length. The family is found in association with Pfam:PF00069. CK1gamma is a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells.. 
+PF12606 Tumour necrosis factor receptor superfamily member 19<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 49 and 288 amino acids in length.  There are two completely conserved residues (K and Y) that may be functionally important. The members of tumor necrosis factor receptor (TNFR) superfamily have been designated as the "guardians of the immune system" due to their roles in immune cell proliferation, differentiation, activation, and death (apoptosis). The messenger RNA of RELT is especially abundant in hematologic tissues such as spleen, lymph node, and peripheral blood leukocytes as well as in leukemias and lymphomas. RELT is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1.. 
+PF12607 Protein of unknown function (DUF3772)<br>This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00924.. 
+PF12608 Protein of unknown function (DUF3773)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are approximately 110 amino acids in length.. 
+PF12609 Wound-induced protein<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 81 and 97 amino acids in length. The proteins in the family are often annotated as wound-induced proteins however there is little accompanying literature to confirm this.. 
+PF12610 Suppressor of cytokine signalling<br>This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF07525, Pfam:PF00017. The suppressors of cytokine signaling (SOCS) family play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms.. 
+PF12611 Protein of unknown function (DUF3766)<br>This domain family is found in bacteria, and is approximately 20 amino acids in length. There is a conserved FTNID sequence motif. There is a single completely conserved residue T that may be functionally important.. 
+PF12612 Tubulin folding cofactor D C terminal<br>This domain family is found in eukaryotes, and is typically between 182 and 199 amino acids in length. The family is found in association with Pfam:PF02985. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerise with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules.. 
+PF12613 Flagellin structural protein<br>This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00669, Pfam:PF00700. This family is the bacterial flagellin structural protein. It is involved with cell motility.. 
+PF12614 Ribosome recycling factor <br>This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 130 amino acids in length. There are two conserved sequence motifs: LPS and LKR. Overproduction of ribosome recycling factor (RRF) reduces tna operon expression and increases the rate of cleavage of TnaC-tRNA(2)(Pro), relieving the growth inhibition associated with plasmid-mediated tnaC overexpression.. 
+PF12615 F sex factor protein N terminal<br>This domain family is found in bacteria, and is typically between 96 and 107 amino acids in length. The family is found in association with Pfam:PF10412. TraD is a cytoplasmic membrane protein with possible DNA binding domains. It is part of the bacterial F sex factor complex.. 
+PF12616 Protein of unknown function (DUF3775)<br>This domain family is found in bacteria, and is approximately 80 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF12617 Iron-Sulfur binding protein C terminal<br>This domain family is found in bacteria and eukaryotes, and is typically between 179 and 201 amino acids in length. The family is found in association with Pfam:PF00037. LdpA (light-dependent period) plays a role in controlling the redox state in cyanobacteria to modulate its. circadian clock. LdpA is a protein with Iron-Sulfur cluster-binding motifs.. 
+PF12618 Protein of unknown function (DUF3776)<br>This domain family is found in eukaryotes, and is approximately 100 amino acids in length.. 
+PF12619 Mini-chromosome maintenance protein 2<br>This domain family is found in eukaryotes, and is typically between 138 and 153 amino acids in length. The family is found in association with Pfam:PF00493. Mini-chromosome maintenance (MCM) proteins are essential for DNA replication. These proteins use ATPase activity to perform this function.. 
+PF12620 Protein of unknown function (DUF3778)<br>This domain family is found in eukaryotes, and is typically between 48 and 61 amino acids in length. There is a conserved LRF sequence motif.. 
+PF12621 Phosphate metabolism protein <br>This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF02714. There are two completely conserved residues (W and D) that may be functionally important. This family is likely to be involved in phosphate metabolism however there is little accompanying literature to confirm this.. 
+PF12622 mRNA biogenesis factor<br>The full-length Wbp11 proteins carry several copies of a PPGPPP motif throughout their length. This motif is thought to be necessary for folding of the molecule as it helps to bind the WW domain, Wbp11, Pfam:PF09429  . This domain together with Wbp11 may function as components of an mRNA factory in the nucleus.. 
+PF12623 RNA repair, ligase-Pnkp-associating, region of Hen1<br>This domain is the N-terminal region of the bacterial Hen1 protein.  This protein forms stable hetero-tetramer with Pnkp. The hetero-tetramer was able to repair transfer RNAs cleaved by ribotoxins in vitro  . This domain provides the ligase activity of the hetero-tetramer.. 
+PF12624 N-terminal region of Chorein, a TM vesicle-mediated sorter<br>Pfam-B_PB000002 (release 24.0). Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.. 
+PF12625 Arabinose-binding domain of AraC transcription regulator, N-term<br>Pfam-B_PB000001 (release 24.0). AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, Pfam:PF00165, and this dimerisation domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].. 
+PF12626 Polymerase A arginine-rich C-terminus<br>Pfam-B_105 (release 24.0). The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.. 
+PF12627 Probable RNA and SrmB- binding site of polymerase A<br>Pfam-B_105 (release 24.0). This region encompasses much of the RNA and SrmB binding motifs on polymerase A.. 
+PF12628 Falstatin, cysteine peptidase inhibitor<br>This family of peptidase inhibitors is expressed from plasmodial protozoal species. Falstatin is found to be a potent reversible inhibitor of the P. falciparum cysteine proteases falcipain-2 and falcipain-3, as well as other parasite- and non-parasite-derived cysteine proteases, but is only a relatively weak inhibitor of the P. falciparum cysteine proteases falcipain-1 and dipeptidyl aminopeptidase 1. Thus, P. falciparum requires expression of falstatin to limit proteolysis by certain host or parasite cysteine proteases during erythrocyte invasion.. 
+PF12629 Poxvirus poly(A) polymerase C-terminal domain<br>This domain is found at the C-terminus of the pox virus PolyA polymerase protein  .. 
+PF12630 Poxvirus poly(A) polymerase N-terminal domain<br>This domain is found at the N-terminus of the pox virus Poly(A) polymerase protein  . According to SCOP this domain contains a helix-hairpin-helix motif.. 
+PF12631 Catalytic cysteine-containing C-terminus of GTPase, MnmE<br>Pfam-B_102 (release 24.0). This short C-terminal region contains the only cysteine present in these proteins. It is proposed that MnmE is a tRNA-modifying enzyme and that Cys-451 functions as a catalytic residue in the modification reaction.. 
+PF12632 Mysoin-binding motif of peroxisomes<br>Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes it binds to class V   and class VIIa   myosins to guide the organelle through the microtubules   and allow pathogens to internalise themselves into host cells  . Vezatin is crucial for spermatozoan production  . In mouse cells it interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA  .. 
+PF12633 Adenylate cyclase NT domain<br>
+PF12634 Inheritance of peroxisomes protein 1<br>Inp1 is a family of peripheral membrane proteins of peroxisomes. Inp1p binds Pex25p, Pex30p, and Vps1p, all of which are involved in controlling peroxisome division. The levels of Inp1p vary with the cell cycle, and Inp1 acts as a factor that retains peroxisomes in cells and controls peroxisome division  . Inp1p promotes the retention of peroxisomes in mother cells and buds of budding yeast by attaching peroxisomes to as-yet-unidentified cortical structures  .. 
+PF12635 Protein of unknown function (DUF3780)<br>This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria. Proteins in this family are typically between 189 and 206 amino acids in length. There are two conserved sequence motifs: PEERWWL and GWR. This family is found in a very sporadic set of bacterial species, suggesting that it may have been horizontally transferred. One protein is annotated as plasmid borne.. 
+PF12636 Protein of unknown function (DUF3781)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 82 and 98 amino acids in length. There are two conserved sequence motifs: GKNWY and ITA.. 
+PF12637 TSCPD domain<br>This family of proteins is found in bacteria, archaea and viruses.  The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD after which the domain is named.  Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulfur cluster. This domain is found at the C-terminus of some ribonucleoside-diphosphate reductase enzymes.. 
+PF12638 Staygreen protein<br>This family of proteins have been implicated in chlorophyll degradation [1,2]. Intriguingly members of this family are also found in non-photosynthetic bacteria.. 
+PF12639 Colicin-DNAse;<br>DNase/tRNase domain of colicin-like bacteriocin. Colicin-like bacteriocins are complex structures with an N-terminal beta-barrel translocation domain (Pfam:PF09000), a long double-alpha-helical receptor-binding domain (Pfam:PF11570) and this C-terminal RNAse/DNase domain with endonuclease activity. Their competitor bacteriocidal action is by a process that involves binding to a surface receptor, entering the cell, and, finally, killing it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3 reveals a Y-shaped molecule with the receptor binding domain forming a 100 Angstrom long stalk and the two globular heads of the translocation domain and this catalytic domain comprising the two arms  .. 
+PF12640 UPF0489 domain<br>This family is probably an enzyme which is related to the Arginase family.. 
+PF12641 Flavodoxin domain<br>This family represents a flavodoxin domain.. 
+PF12642 Conjugative transposon protein TcpC<br>This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologues from Tn916, Tn5397, and CW459tet  .\.  This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.. 
+PF12643 MazG-like family<br>This family of short proteins are distantly related to the MazG enzyme. This suggests that these proteins are enzymes that catalyse a related reaction.. 
+PF12644 Protein of unknown function (DUF3782)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 91 and 186 amino acids in length.. 
+PF12645 Helix-turn-helix domain<br>This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.. 
+PF12646 Domain of unknown function (DUF3783)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.. 
+PF12647 RNHCP domain<br>This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 143 amino acids in length. There is a conserved RNHCP sequence motif.. 
+PF12648 TcpE family<br>This family of proteins includes TcpE a conjugative transposon membrane protein.This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 168 amino acids in length.. 
+PF12650 Domain of unknown function (DUF3784)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 96 and 110 amino acids in length.. 
+PF12651 Ribbon-helix-helix domain<br>This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.. 
+PF12652 CotJB protein<br>CotJ is a sigma E-controlled operon involved in the spore coat of Bacillus subtilis  . This protein has been identified as a spore coat protein  .. 
+PF12653 Protein of unknown function (DUF3785)<br>
+PF12654 Domain of unknown function (DUF3786)<br>Pfam-B_16102 (release 23.0) . This presumed domain is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 201 and 257 amino acids in length. Some proteins also contains an iron-sulfur cluster.. 
+PF12655 Domain of unknown function (DUF3787)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in Clostridia. Proteins in this family are approximately 60 amino acids in length. There is a conserved TAAW sequence motif that may be functionally important.. 
+PF12656 DExH-box splicing factor binding site<br>Pfam-B_900 (release 24.0). Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2  . As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2  .. 
+PF12657 Transcription factor IIIC subunit delta N-term<br>In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts  . The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8  .. 
+PF12658 Telomere capping, CST complex subunit<br>Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex  . These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast.  Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution  . Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms  .. 
+PF12659 Telomere capping C-terminal wHTH<br>This domain consists of tandem winged helix-turn-helix motifs. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex  . These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution  .. 
+PF12660 Putative zinc-finger of transcription factor IIIC complex<br>This zinc-finger domain is at the very C-terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions  .. 
+PF12661 Human growth factor-like EGF<br>Wouters M, Coggill P. hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan.  The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC.  These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin.  Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.. 
+PF12662 Complement Clr-like EGF-like<br>Wouters M, Coggill P. cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin.  Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.. 
+PF12663 Protein of unknown function (DUF3788)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 137 and 149 amino acids in length. This family may be distantly related to RelE proteins.. 
+PF12664 Protein of unknown function (DUF3789)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two completely conserved residues (V and C) that may be functionally important.. 
+PF12666 PrgI family protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 116 and 146 amino acids in length. This protein is found in an operon that is part of a Type IV secretion system.. 
+PF12667 NigD-like protein<br>JCSG target Q5LAY5_BACFN. This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroides species. Proteins in this family are typically between 234 and 260 amino acids in length. These proteins possess an N-terminal lipoprotein attachment site. The family includes NigD a protein found in the Nig operon that encodes a bacteriocin called nigrescin. It has been suggested that NigD may be the immunity protein for nigrescin (NigC) because it is directly downstream  .. 
+PF12668 Protein of unknown function (DUF3791)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 71 and 125 amino acids in length.. 
+PF12669 Virus attachment protein p12 family<br>This family of proteins are related to Virus attachment protein p12 from the African swine fever virus. The family appears to contain an N-terminal signal peptide followed by a short cysteine rich region. The cysteine rich region is extremely variable and it is possible that only the N-terminal region is homologous.. 
+PF12670 Protein of unknown function (DUF3792)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. These proteins are integral membrane proteins.. 
+PF12671 Putative amidase domain<br>
+PF12672 Protein of unknown function (DUF3793)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 211 amino acids in length. There are two conserved sequence motifs: PHE and LGYP.. 
+PF12673 Domain of unknown function (DUF3794)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF01476.. 
+PF12674 Putative zinc ribbon domain<br>This domain appears to be a zinc binding DNA-binding domain.. 
+PF12675 Protein of unknown function (DUF3795)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.. 
+PF12676 Protein of unknown function (DUF3796)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF12677 Domain of unknown function (DUF3797)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif.. 
+PF12678 RING-H2 zinc finger<br>There are 8 cysteine/ histidine residues which are proposed to be the conserved residues involved in zinc binding. The protein, of which this domain is the conserved region, participates in diverse functions relevant to chromosome metabolism and cell cycle control  .. 
+PF12679 ABC-2 family transporter protein<br>This family is related to the ABC-2 membrane transporter family  .. 
+PF12680 SnoaL-like domain<br>This family contains a large number of proteins that share the SnoaL fold.. 
+PF12681 Glyoxalase-like domain<br>This domain is related to the Glyoxalase domain Pfam:PF00903.. 
+PF12682 Flavodoxin<br>This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.. 
+PF12683 Protein of unknown function (DUF3798)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 247 and 417 amino acids in length. Most of the proteins in this family have an N-terminal lipoprotein attachment site. These proteins have distant similarity to periplasmic ligand binding families such as Pfam:PF02608, which suggests that this family have a similar role.. 
+PF12684 PDDEXK-like domain of unknown function (DUF3799)<br>Jackhmmer:JCSG target 392282. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in Pfam:PF01930.. 
+PF12685 SpoIIIAH-like protein<br>Stage III sporulation protein AH (SpoIIIAH) is a protein that is involved in forespore engulfment. It forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.  This family of proteins is found in bacteria, archaea and eukaryotes and so must have a wider function that in sporulation.  Proteins in this family are typically between 174 and 223 amino acids in length.. 
+PF12686 Protein of unknown function (DUF3800)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 215 and 302 amino acids in length. There is a DE motif at the N-terminus and a QXXD motif at the C-terminus that may be functionally important.. 
+PF12687 Protein of unknown function (DUF3801)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 158 and 187 amino acids in length. This family includes the PcfB protein.. 
+PF12688 Tetratrico peptide repeat<br>BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions.  This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the Pfam:PF00515, Pfam:PF07719, Pfam:PF07720 and Pfam:PF07221 models.. 
+PF12689 Acid Phosphatase<br>This family contains phosphatase enzymes and other proteins of the HAD superfamily.  It includes MDP-1 which is a eukaryotic magnesium-dependent acid phosphatase [1-2].. 
+PF12690 Intracellular proteinase inhibitor<br>This is a bacterial domain which has been named BsuPI in Bacillus subtilis.\.      This domain is found in Swiss:P39804, where it has been suggested to regulate the major intracellular proteinase (ISP-1) activity in vivo  .  The structure of proteins in this family adopt a beta barrel topology.. 
+PF12691 Minor capsid protein from bacteriophage<br>This family is from one of three adjacent genes, all of which are involved in formation of the minor phage capsid.. 
+PF12692 S-adenosyl-L-methionine methyltransferase<br>This domain is found in bacterial proteins.  The structure of the proteins in this family suggest that they function as a methyltransferase.. 
+PF12693 GspL periplasmic domain<br>This domain is the periplasmic domain of the GspL/EpsL family proteins. These proteins are involved in type II secretion systems.. 
+PF12694 Putative molybdenum carrier<br>The structure of proteins in this family contain central beta strands with flanking alpha helices.  The structure is similar to that of a molybdenum cofactor carrier protein.. 
+PF12695 Alpha/beta hydrolase family<br>Jackhmmer:Q186B9_CLOD6. This family contains a diverse range of alpha/beta hydrolase enzymes.. 
+PF12696 TraM recognition site of TraD and TraG<br>Pfam-B_1146 (release 5.4). This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation.  These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems  . This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore  .. 
+PF12697 Alpha/beta hydrolase family<br>Jackhmmer:Q186D8_CLOD6. This family contains alpha/beta hydrolase enzymes of diverse specificity.. 
+PF12698 ABC-2 family transporter protein<br>Jackhmmer:Q17ZU3_CLOD6. This family is related to the ABC-2 membrane transporter family Pfam:PF01061  .. 
+PF12699 phiKZ-like phage internal head proteins<br>Hardies SC, Coggill P. Phage internal head proteins (IP) are proteins that are encoded by a bacteriophage and assembled into the mature virion inside the capsid head.  The most analogous characterised IP proteins are those of bacteriophage T4, which are known to be proteolytically processed during phage maturation, and then subsequently injected into the host cell during infection. The phiKZ_IP family consists of internal head proteins encoded by phiKZ-like phages.  Each phage encodes three to six members of this family  .  Members of the family reside in the head   and are cleaved during phage maturation to separate an N-terminal propeptide from a C-terminal domain.  The C-terminal domain remains in the mature capsid.  The N-terminal propeptide domain is either mostly or completely removed from the mature capsid. In one case, an unrelated polypeptide is embedded in the propeptide and also remains in the mature capsid.  The phiKZ-like IP proteins are not discernibly homologous to the T4 IP proteins, and it is not known if the phiKZ-like IP proteins are injected into the host cell, or have some other function within the head. The alignment and HMM model exclude most of the propeptide region, but include the cleavage sites.  The first 100 residues, including the cleavage sites, constitute the most conservative part of the seed alignment.. 
+PF12700 HlyD family secretion protein<br>Jackhmmer:Q182V7_CLOD6. This family is related to Pfam:PF00529.. 
+PF12701 Scd6-like Sm domain<br>The Scd6-like Sm domain is found in Scd6p from S. cerevisiae, Rap55 from the newt Pleurodeles walt, and its orthologs from fungi,  animals, plants and apicomplexans  . The domain is also found in  Dcp3p and the human EDC3/FLJ21128 protein where it is fused to the  the Rossmanoid YjeF-N domain [1,2]. In addition both EDC3 and Scd6p are found fused to the FDF domain [1,2].. 
+PF12702 DUF3803;<br>JCSG_target_392987_3hty Pfam-B_17140 (release 24.0). This is a family of proteins of 115 residues on average.  The family has two highly conserved tryptophan residues. The fold is very similar to the lipocalin-like fold from several comparable structures.. 
+PF12703 Toxin of toxin-antitoxin type 1 system<br>Gardner P, Coggill P. This family is the toxin of a type 1 toxin-antitoxin system which is found in a relatively widespread range of bacterial species. The species distribution suggests frequent horizontal gene transfer.  In a type 1 system, as characterised for the plasmid-encoded E coli hok/sok system, the toxin-encoding stable mRNA encodes a protein which rapidly leads to cell death unless the translation is suppressed by a short-lived small RNA. The plasmid-encoded module prevents the growth of plasmid-free offspring, thus ensuring the persistence of the plasmid in the population. Plasmid-free cells arising after cell-division will be killed because the stable mRNA toxin is present while the comparably unstable anti-toxin is rapidly degraded. Where the system is transcribed chromosomally, the mechanism is poorly understood  .. 
+PF12704 MacB-like periplasmic core domain<br>This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein  . Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter.. 
+PF12705 PD-(D/E)XK nuclease superfamily<br>Jackhmmer:Q18AP1_CLOD6. Members of this family belong to the PD-(D/E)XK nuclease superfamily. 
+PF12706 Beta-lactamase superfamily domain<br>Jackhmmer:Q189N7_CLOD6. This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.. 
+PF12707 Protein of unknown function (DUF3804)<br>This family is approximately 130 residues.  Dali search indicates this protein carries a NTF2-fold with a hydrophobic cavity as a structural homologue to 1JB2, 2R4I, 3FSD and 2UX0.  In this hydrophobic cavity, Arg 118 provides the H-bonding force to hold a PEG molecule from crystallisation. The interface interaction suggests that the biomolecule of Swiss:Q46KI2 is a dimer. Two members of the family are annotated as putative EF-Tu domain 2 but there is no match to this family so this is likely to be a false assignment. There are two highly conserved tryptophan residues towards the C-terminal end of the family.. 
+PF12708 Pectate lyase superfamily protein<br>Jackhmmer:Q184L0_CLOD6. This family of proteins possesses a beta helical structure like Pectate lyase.  This family is most closely related to glycosyl hydrolase family 28.. 
+PF12709 Central kinetochore-associated<br>This is a family of proteins integrally involved in the central kinetochore. Slk19 is a yeast member and it may play an important role in the timing of nuclear migration. It may also participate, directly or indirectly, in the maintenance of centromeric tensile strength during mitotic stagnation, for instance during activation of checkpoint controls, when cells need to preserve nuclear integrity until cell cycle progression can be resumed  .. 
+PF12710 haloacid dehalogenase-like hydrolase<br>Jackhmmer:Q18AI1_CLOD6. 
+PF12711 Kinesin motor<br>This family is closely related to Kinesin-related, Pfam:PF06548.. 
+PF12712 Domain of unknown function (DUF3805)<br>This family represent the N-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1tui, also of unknown function. The domain carries four conserved tryptophan residues.. 
+PF12713 Domain of unknown function (DUF3806)<br>This family represent the C-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1ma7 whose C-terminal domain is a phage integrase, Pfam:PF00589.. 
+PF12714 TILa domain<br>Pfam-B_897 (release 5.2). This cysteine rich domain occurs along side the TIL Pfam:PF01826 domain and is likely to be a distantly related relative.. 
+PF12715 Abhydrolase family<br>This is a family of probable bacterial abhydrolases.. 
+PF12716 Nuclear pore assembly and biogenesis<br>This is a family of conserved fungal proteins involved in nuclear pore assembly  . Apq12 is an integral membrane protein of the nuclear envelope (NE) and endoplasmic reticulum. Its absence leads to a partial block in mRNA export and cold-sensitive defects in the growth and localisation of a subset of nucleoporins, particularly those asymmetrically localised to the cytoplasmic fibrils  . The defects in nuclear pore assembly appear to be due to defects in regulating membrane fluidity  .. 
+PF12717 non-SMC mitotic condensation complex subunit 1<br>Pfam-B_410 (release 24.0). The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.. 
+PF12718 Tropomyosin like<br>This family is a set of eukaryotic tropomyosins. Within the yeast Tmp1 and Tmp2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpmlp spans five.  Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis  . The family also contains higher eukaryote Tmp3 members.. 
+PF12719 Nuclear condensing complex subunits, C-term domain<br>Pfam-B_484 (release 24.0). The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.. 
+PF12720 Protein of unknown function (DUF3807)<br>This is a family of conserved fungal proteins of unknown function.. 
+PF12721 RIP homotypic interaction motif<br>RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins  . This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI  .. 
+PF12722 High-temperature-induced dauer-formation protein<br>Hid1 (high-temperature-induced dauer-formation protein 1) represents proteins of approximately 800 residues long and is conserved from fungi to humans. It contains up to seven potential transmembrane domains separated by regions of low complexity. Functionally it might be involved in vesicle secretion or be an inter-cellular signalling protein or be a novel insulin receptor  .. 
+PF12723 Protein of unknown function (DUF3809)<br>Jackhmmer:NP_295729.1. This family of proteins is functionally uncharacterised. This family of proteins is found in Deinococci bacteria. Proteins in this family are typically between 117 and 157 amino acids in length.. 
+PF12724 Flavodoxin domain<br>Jackhmmer:Q186N5_CLOD6. This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.. 
+PF12725 Protein of unknown function (DUF3810)<br>Jackhmmer:Q185R6_CLOD6. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 333 and 377 amino acids in length. There is a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterised family of peptidase enzymes.. 
+PF12726 SEN1 N terminal<br>Pfam-B_2547 (release 24.0). This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes  . The N terminal of SEN1, unlike the C terminal, is not required for growth  .. 
+PF12727 PBP superfamily domain<br>Jackhmmer:Q18A58_CLOD6. This family belongs to the periplasmic binding domain superfamily. It is often associated with a helix-turn-helix domain.. 
+PF12728 Helix-turn-helix domain<br>Jackhmmer:Q18A58_CLOD6. This domain is a DNA-binding helix-turn-helix domain.. 
+PF12729 4HB_MCP_2;<br>Four helix bundle sensory module for signal transduction. This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.. 
+PF12730 ABC-2 family transporter protein<br>Jackhmmer:Q18D57_CLOD6. This family is related to the ABC-2 membrane transporter family Pfam:PF01061  .. 
+PF12731 Mating-type protein beta 1<br>Pfam-B_4610 (release 8.0). This domain is found in some fungi and is the C-terminus of a homeodomain-containing transcription factor protein involved in mating.. 
+PF12732 YtxH-like protein<br>Jackhmmer:Q18C91_CLOD6. This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterised.. 
+PF12733 Cadherin-like beta sandwich domain<br>Aravind L, Coggill P. This domain is found in several bacterial, metazoan and chlorophyte algal proteins.  A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.. 
+PF12734 Cysteine-rich TM module stress tolerance<br>Aravind L, Coggill P. The members of this family are short cysteine-rich membrane proteins that most probably dimerise together to form a transmembrane sulfhydryl-lined pore. The CYSTM module is always present at the extreme C-terminus of the protein in which it is present. Furthermore, like the yeast prototypes, the majority of the proteins also possess a proline/glutamine-rich segment upstream of the CYSTM module that is likely to form a polar, disordered head in the cytoplasm. The presence of an atypical well-conserved acidic residue at the C-terminal end of the TM helix suggests that this might interact with a positively charged moiety in the lipid head group. Consistently across the eukaryotes, the different versions of the CYSTM module appear to have roles in stress-response or stress-tolerance, and, more specifically, in resistance to deleterious substances, implying that thes might be general functions of the whole family.. 
+PF12735 TRAPP trafficking subunit Trs65<br>This family is one of the subunits of the TRAPP Golgi trafficking complex  . TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II. While both complexes contain the same seven subunits, Bet3p, Bet5p, Trs20p, Trs23p, Trs31p, Trs33p and Trs85p, with TRAPPC human equivalents, TRAPP II has the additional three subunits ,Trs65p, Trs120p and Trs130p  . While it has been implicated in cell wall biogenesis and stress response, the role of Trs65 in TRAPP II is supported by the findings that the protein co-localises with Trs130p, and deletion of TRS65 in yeast leads to a conditional lethal phenotype if either one of the other TRAPP II-specific subunits is modified  . Furthermore, the trs65 mutant has reduced Ypt31/32p guanine nucleotide exchange, GEF, activity  .. 
+PF12736 Cell-cycle sustaining, positive selection, <br>Aravind L, Coggill P. The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.. 
+PF12737 C-terminal domain of homeodomain 1<br>Pfam-B_4610 (release 8.0). Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.. 
+PF12738 twin BRCT domain<br>Pfam-B_181 (release 24.0). This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair [1,2].. 
+PF12739 ER-Golgi trafficking TRAPP I complex 85 kDa subunit<br>This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport  . Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion  . The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2) , Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.. 
+PF12740 Chlorophyllase enzyme<br>This family consists of several chlorophyllase and chlorophyllase-2 (EC:3.1.1.14) enzymes. Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyses the hydrolysis of an ester bond to yield chlorophyllide and phytol  . The family includes both plant and Amphioxus members.. 
+PF12741 Susd and RagB outer membrane lipoprotein <br>This is a family of SusD-like proteins, one member of which, BT1043 (Swiss:Q8A8X4), is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologues in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.. 
+PF12742 Gryzun, putative Golgi trafficking<br>Members of this family are involved in Golgi trafficking.. 
+PF12743 Oestrogen-type nuclear receptor final C-terminal <br>This is the very C-terminal region of a subfamily of nuclear receptors that includes oestrogen receptors and other subfamily 3 group A members. The actual function of this region is not known, but the domain is absent from all the other types of nuclear receptors. Oestrogen receptors modulate AP-1-dependent transcription   through two distinct mechanisms: via protein-protein interactions on DNA; and via non-genomic actions. The mechanism used depends on the cellular localisation of the receptor. In addition to the more extensively studied cross-talk on DNA, additional non-genomic actions might be very important in target tissues in which membrane-associated ERs are found. These non-genomic actions probably contribute to the overall physiological responses mediated by ligand-bound ERs   and might possibly be mediated via this C-terminal domain.. 
+PF12744 Autophagy protein Atg19, Atg8-binding<br>Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. In contrast to autophagy, however, the Cvt pathway is a highly selective process that involves the sequestration of at least two specific cargos that are resident vacuolar hydrolases, aminopeptidase I (Ape1) and alpha-mannosidase (Ams1). These proteins are sequestered within a double-membrane vesicle, termed a Cvt vesicle. The Cvt vesicle is fairly consistent in size, and is much smaller than the autophagosome, being 140-160 nm in diameter. The prApe1 is sequestered within either Cvt vesicles or autophagosomes, depending on the nutrient conditions, and delivered to the vacuole. Autophagy and the Cvt pathway are topologically and mechanistically similar and share most of the same machinery. The Ape1 complex is ultimately enwrapped within either Cvt vesicles or autophagosomes at the perivacuolar PAS. The receptor protein Atg19 binds to the Ape1 complex through the prApe1 propeptide to form the Cvt complex in the cytosol. In the absence of Atg19, prApe1 can form an Ape1 complex, but does not localise at the PAS. Atg19 is a peripheral membrane protein with differing binding sites for both Ape1 and Ams1. The Atg8-binding region in the yeast proteins is this very C-terminal residues  .. 
+PF12745 Anticodon binding domain of tRNAs<br>Pfam-B_20896 (release 24.0). This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations.. 
+PF12746 GNAT acetyltransferase<br>Many of the members are annotated s being Zwittermicin A resistance proteins, whereas others are listed as being GNAT acetyltransferases.  The family has similarities to the GNAT acetyltransferase family.. 
+PF12747 DdrB-like protein<br>This family includes the Deinococcus DdrB protein which is a ssDNA binding protein. This family also includes some possibly distantly related cyanobacterial proteins. However, these are not strongly supported. The structure of DdrB is known.. 
+PF12749 Eukaryotic metallothionein<br>This is a family of eukaryotic metallothioneins.. 
+PF12750 Maff2 family<br>Jackhmmer:Q187G1_CLOD6. This family of short membrane proteins are related to the protein Maff2. Maff2 lies just outside the direct repeats of a tetracycline resistance transposable element. This protein may contain transmembrane helices.. 
+PF12751 Vacuolar segregation subunit 7<br>Pfam-B_10847 (release 24.0). Vac7 is localised at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance  . Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway  . The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.. 
+PF12752 SUZ domain<br>The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.. 
+PF12753 Nuclear pore complex subunit Nro1<br>Pfam-B_4826 (release 24.0). 
+PF12754 Cell-cycle control medial ring component<br>During size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1, Blt1 has been shown to co-localise with Cdr2 in the medial interphase nodes, as well as with Mid1 which was previously shown to localise to similar interphase structures. Physical interactions between Blt1-Mid1, Blt1-Cdr2 and Cdr2-Mid1 were detected, indicating that medial cortical nodes are formed by the ordered, Cdr2-dependent assembly of multiple interacting proteins during interphase. Q5KIH8.1/10-346; Q5KIH8.1/10-90;. 
+PF12755 Vacuolar 14 Fab1-binding region<br>Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.. 
+PF12756 C2H2 type zinc-finger (2 copies)<br>Pfam-B_88 (release 24.0). This family contains two copies of a C2H2-like zinc finger domain.. 
+PF12757 Protein of unknown function (DUF3812)<br>Pfam-B_8029 (release 24.0). This is a family of fungal proteins whose function is not known.. 
+PF12758 Protein of unknown function (DUF3813)<br>PfamB_1273 (release 24.0). This is an uncharacterised family of Bacillus proteins.. 
+PF12759 InsA_C;<br>InsA C-terminal domain. This short domain is found at the C-terminus of the InsA protein. This domain contains a helix-turn-helix domain.. 
+PF12760 Zn_ribbon_3;<br>Transposase zinc-ribbon domain. Pfam-B_3 (Release 24.0). This zinc binding domain is found in a range of transposase proteins such as ISSPO8, ISSOD11, ISRSSP2 etc. It is likely a zinc-binding beta ribbon domain that could bind the DNA.. 
+PF12761 E3;<br>Actin cytoskeleton-regulatory complex protein END3. Pfam-B_51079 (release 24.0). Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release  . End3p is part of the coat module protein complex Pan1, along with Pan1p, Sla1p, and Sla2p  . The proteins in this complex are regulated by phosphorylation events. End3p also regulates the cortical actin cytoskeleton [3,4]. The subunits of the Pan1 complex are homologous to mammalian intersectin.. 
+PF12762 Transposase_38;<br>ISXO2-like transposase domain. Pfam-B_3 (Release 24.0). This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.. 
+PF12763 efhand_3;<br>Cytoskeletal-regulatory complex EF hand. Pfam-B_51079 (release 24.0). This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.. 
+PF12764 Glycine-rich region of argonaut<br>Pfam-B_7248 (release 24.0). This domain is often found at the very N-terminal of argonaut-like proteins.. 
+PF12765 HEAT repeat associated with sister chromatid cohesion<br>Pfam-B_443 (release 24.0). This HEAT repeat is found most frequently in sister chromatid cohesion proteins such as Nipped-B. HEAT repeats are found tandemly repeated in many proteins, and they appear to serve as flexible scaffolding on which other components can assemble.. 
+PF12766 Pyridoxamine 5'-phosphate oxidase<br>Pfam-B_2486 (release 24.0). Pyridoxamine 5'-phosphate oxidase catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP), the terminal step in the de novo biosynthesis of PLP in Escherichia coli and part of the salvage pathway of this coenzyme in both E. coli and mammalian cells. This region is the flavoprotein FMN-binding domain.. 
+PF12767 Transcriptional regulator of RNA polII, SAGA, subunit<br>Pfam-B_319 (release 24.0). The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II [1,2]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA  . The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.. 
+PF12768 Cortical protein marker for cell polarity<br>Pfam-B_2071 (release 24.0). Diploid yeast cells repeatedly polarize and bud from their poles, due probably to the presence of highly stable membrane markers, and Rax2 is one such marker. It is inherited immutably at the cell cortex for multiple generations, and has a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means of coupling a cell's history with the future development of a precise morphogenetic form  . Both Rax1 and Rax2 localise to the distal pole as well as to the division site and they interact both with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical markers for bipolar budding  . thus Rax2 is likely to control cell polarity during vegetative growth, and in fission yeast this is done by regulating the localisation of for3p  .. 
+PF12769 Domain of unknown function (DUF3814)<br>Pfam-B_10 (release 24.0). This is a domain of unknown function.  It is often found in combination with Pfam:PF05222, Pfam:PF01262 and Pfam:PF02233 on alanine dehydrogenase and pyridine nucleotide transhydrogenase enzymes.. 
+PF12770 CHAT domain<br>Pfam-B_4 (Release 24.0). These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins  .. 
+PF12771 Starch-binding associating with outer membrane<br>JCSG structure (Target 390167). SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.. 
+PF12772 Growth hormone receptor binding<br>Pfam-B_7 (release 24.0). Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme) [1,2]. Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone  . The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage  .. 
+PF12773 Double zinc ribbon<br>Pfam-B_12 (Release 24.0). This family consists of a pair of zinc ribbon domains.. 
+PF12774 Hydrolytic ATP binding site of dynein motor region D1<br>Pfam-B_14 (release 24.0). the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D1 unit of the motor and contains the hydrolytic ATP binding site  . . 
+PF12775 P-loop containing dynein motor region D3<br>Pfam-B_14 (release 24.0). the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D3 and is an ATP binding site  .. 
+PF12776 Myb/SANT-like DNA-binding domain<br>Pfam-B_16 (Release 24.0). This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular Pfam:PF10545 seems most related.  This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.. 
+PF12777 Microtubule-binding stalk of dynein motor<br>Pfam-B_14 (release 24.0). the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component  .. 
+PF12778 PXPV repeat (3 copies)<br>Pfam-B_15 (Release 24.0). This short repeat is found in multiple copies in a variety of Burkholderia proteins. The function of this region is unknown.. 
+PF12779 YXWGXW repeat (2 copies)<br>Pfam-B_15 (Release 24.0). This short repeat contains the motif YXWXXGXW where X can be any amino acid.  It is generally found in 2-5 copies in short secreted bacterial proteins. Its function is as yet unknown.. 
+PF12780 P-loop containing dynein motor region D4<br>Pfam-B_14 (release 24.0). The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor  .. 
+PF12781 ATP-binding dynein motor region D5<br>Pfam-B_14 (release 24.0). The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution.  This particular family is the D5 ATP-binding region of the motor, but has lost its P-loop  .. 
+PF12782 Invertebrate innate immunity transcript family<br>Pfam-B_9 (release 24.0). The immune response of the purple sea urchin appears to be more complex than previously believed in that it uses immune-related gene families homologous to vertebrate Toll-like and NOD/NALP-like receptor families as well as C-type lectins and a rudimentary complement system. In addition, the species also produces this unusual family of mRNAs, also known as 185/333, which is strongly upregulated in response to pathogen challenge  .. 
+PF12783 Guanine nucleotide exchange factor in Golgi transport N-terminal<br>Pfam-B_13 (release 24.0). The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF  .   . 
+PF12784 PD-(D/E)XK nuclease family transposase<br>Pfam-B_5 (Release 24.0). Members of this family belong to the PD-(D/E)XK nuclease superfamily  . These proteins are transposase proteins.. 
+PF12785 Variant erythrocyte surface antigen-1<br>Pfam-B_22 (release 24.0). This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.. 
+PF12786 GB virus C genotype envelope<br>Pfam-B_19 (release 24.0). This the envelope protein from the ssRNA GB virus genotype C.. 
+PF12787 EcsC protein family<br>Jackhmmer:Q186V8_CLOD6. Proteins in this family are related to EcsC from B. subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system  . The function of this protein is unknown.. 
+PF12788 YmaF family<br>This family of proteins contain 6 HXH motifs and is named after the B. subtilis YmaF protein.\.  It seems likely that these are involved in metal binding. The function of this protein is unknown.. 
+PF12789 Phage tail repeat like<br>This family largely contains proteins from the eukaryote Trichomonas vaginalis.  These proteins contain multiple HXH repeats. Some proteins in this family are annotated as having phage tail repeats. The function of this family is unknown.. 
+PF12790 Type VI secretion lipoprotein<br>Pfam-B_27 (release 24.0). One of the virulence mechanisms of E coli is the production of toxins which it produces from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to upto more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as ABC transporters (type I), type IV pili (type 2), flagella (type 3), or conjugative machines (type IV). The type VI secretion system (T6SS) is present in most pathogens that have contact with animals, plants, or humans. SciN is a lipoprotein tethered to the outer membrane and expressed in the periplasm of E coli and is essential for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation.. 
+PF12791 Anti-sigma factor N-terminus<br>Borovok I, Coggill P. The heat shock genes in B. subtilis can be classified into several groups according to their regulation  , and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes  . Regulation of sigma factor I is carried out by RsgI from the same operon, and this N-terminal cytoplasmic portion of RsgI ('upstream' of the single transmembrane helix) has been shown to interact directly with Sigma-I  .. 
+PF12792 CSS motif domain associated with EAL <br>This family with its characteristic highly conserved CSS sequence motif is found N-terminal to the EAL, Pfam:PF00563, domain in many cyclic diguanylate phosphodiesterases.. 
+PF12793 Sugar transport-related sRNA regulator N-term<br>Pfam-B_33 (release 24.0). Small, non-coding RNA molecules play important regulatory roles in a variety of physiological processes in bacteria. SgrR_N is the N-terminus of a family of proteins which regulate the transcription of these sRNAs, in particular SgrS. SgrR_N contains a helix-turn-helix motif characteristic of winged-helix DNA-binding transcriptional regulators. SgrS is a small RNA required for recovery from glucose-phosphate stress in bacteria  . In examining the regulation of sgrR expression it was found that SgrR negatively auto-regulates its own transcription in the presence and absence of stress, and thus SgrR coordinates the response to glucose-phosphate stress by binding specifically to sgrS promoter DNA  .. 
+PF12794 Mechanosensitive ion channel inner membrane domain 1<br>Pfam-B_24 (release 24.0). The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this domain is one of the inner membrane domains.. 
+PF12795 Mechanosensitive ion channel porin domain<br>Pfam-B_24 (release 24.0). The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.. 
+PF12796 Ankyrin repeats (3 copies)<br>Jackhmmer:Q183I8_CLOD6. 
+PF12797 4Fe-4S binding domain<br>This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF12798 4Fe-4S binding domain<br>This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF12799 Leucine Rich repeats (2 copies)<br>Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions.  Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.. 
+PF12800 4Fe-4S binding domain<br>This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF12801 4Fe-4S binding domain<br>Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF12802 MarR family<br>The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR.  A large number of compounds induce transcription of the mar operon.  This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds  . The structure of MarR is known   and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.. 
+PF12803 mRNA (guanine-7-)methyltransferase (G-7-MTase)<br>The Sendai virus RNA-dependent RNA polymerase complex, which consists of L and P proteins, participates in the synthesis of viral mRNAs that possess a methylated cap structure. The N-terminal of the L protein acts as the RNA-dependent RNA polymerase part of the molecule, family Paramyx_RNA_pol, Pfam:PF00946. This domain is the C-terminal part of the L protein and it catalyses cap methylation through its mRNA (guanine-7-)methyltransferase (G-7-MTase) activity  .. 
+PF12804 MobA-like NTP transferase domain<br>This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain.. 
+PF12805 FUSC-like inner membrane protein yccS<br>Pfam-B_45 (release 24.0). This family has similarities to the fusaric acid resistance protein family. The proteins are lodged in the inner membrane.. 
+PF12806 Acetyl-CoA dehydrogenase C-terminal like<br>Pfma-B_46 (release 24.0). this domain would appear to be the very C-terminal region of many bacterial acetyl-CoA dehydrogenases.. 
+PF12807 Translation initiation factor eIF3 subunit 135<br>Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation  .. 
+PF12808 Mto1_bdg;<br>Micro-tubular organiser Mto1 C-term Mto2-binding region. Wood V, Coggill P, Eberhardt R. Pfam-B_28820 (release 24.0). The C-terminal region of the micro-tubular organiser protein 1 (mto1) is the binding domain for attachment to Mto2p.The full-length Mto1 protein is required for microtubule nucleation from non-spindle pole body MTOCs in fission yeast  . The interaction of Mto2p with this region of Mto1 is critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis  .. 
+PF12809 Eukaryotic metallothionein<br>This is a family of eukaryotic metallothioneins.. 
+PF12810 Glycine rich protein<br>This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.. 
+PF12811 Bax inhibitor 1 like <br>The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.. 
+PF12812 PDZ-like domain<br>Pfam-B_17100 (release 24.0). PDZ domains are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates. this is a family of PDZ-like domains from bacteria, plants and fungi.. 
+PF12813 XPG domain containing<br>Pfam-B_10579 (release 24.0). This family is largely of fungal proteins and is related to the XP-G protein family.. 
+PF12814 Meiotic cell cortex C-terminal pleckstrin homology<br>Pfam-B_1220 (release 24.0). The PH domain of these largely fungal proteins is necessary for the cortical localisation of the protein during meiosis, since the overall function of the protein is to anchor dynein at the cell cortex during the horsetail phase. During prophase I of fission yeast, horsetail nuclear movement occurs, and this starts when all the telomeres become bundled at the spindle pole body - SPB. Subsequent to this, the nucleus undergoes a dynamic oscillation, resulting in elongated nuclear morphology. Horsetail nuclear movement is thought to be predominantly due to the pulling of astral microtubules that link the SPB to cortical microtubule-attachment sites at the opposite end of the cell; the pulling force is believed to be provided by cytoplasmic dynein and dynactin.. 
+PF12815 Spt5 C-terminal nonapeptide repeat binding Spt4<br>Pfam-B_197031 (release 23.0). The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe  . The repeat has a characteristic TPA motif.. 
+PF12816 Golgi CORVET complex core vacuolar protein 8<br>Pfam-B_90 (release 24.0). Vps8 is one of the Golgi complex components necessary for vacuolar sorting  . Eukaryotic cells contain a highly dynamic endo-membrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering).  Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intralumenal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes  .. 
+PF12818 dsDNA viral tegument protein<br>Pfam-B_48 (release 24.0). This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.. 
+PF12819 Carbohydrate-binding protein of the ER<br>Pfam-B_41 (release 24.0). Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases.. 
+PF12820 Serine-rich domain associated with BRCT<br>Pfam-B_51 (release 24.0). This domain is found on BRCA1 proteins.. 
+PF12821 Protein of unknown function (DUF3815)<br>This family of membrane proteins is functionally uncharacterised.. 
+PF12822 Protein of unknown function (DUF3816)<br>This family of proteins is functionally uncharacterised but are likely to be membrane transporters. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 177 and 208 amino acids in length. A subset of this family  is associated with the TM1506 proteins. In this context, transport through the channel is predicted to be regulated by the TM1506 protein by either regulating redox potential or modification of substrates  . 
+PF12823 Domain of unknown function (DUF3817)<br>Pfam-B_123 (release 24.0). This domain is of unknown function.  It is sometimes found adjacent to Pfam:PF07690 and Pfam:PF03176 which are both transporter domains.. 
+PF12824 Mitochondrial ribosomal protein subunit L20<br>Pfam-B_1364 (release 24.0). This family is the essential mitochondrial ribosomal protein subunit L20 of fungi.. 
+PF12825 Domain of unknown function in PX-proteins (DUF3818)<br>Pfam-B_972 (release 24.0). This domain is found on proteins carrying a PX domain. Its function is unknown.. 
+PF12826 Helix-hairpin-helix motif<br>Jackhmmer:DISA_CLOD6. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain  .. 
+PF12827 Peroxisomal biogenesis protein family<br>Pfam-B_15020 (release 24.0). Peroxin-22 is a integral peroxisomal membrane protein family. The N-terminus is in the matrix and the C-terminus is in the cytosol. The N-terminus carries a 25-amino acid peroxisome membrane-targeting signal. It interacts with the ubiquitin-conjugating peripheral peroxisomal membrane enzyme Pex4p anchoring it at the peroxisomal membrane. Both Pex proteins are involved at the same stage of peroxisome biogenesis.. 
+PF12828 PX-associated<br>Pfam-B_972 (release24,0). This domain is associated with the PX domain.. 
+PF12829 Transcriptional regulation of mitochondrial recombination<br>Pfam-B_7788 (release 24.0). This family is involved in the transcriptional regulation of recombination in the mitochondria,. 
+PF12830 Sister chromatid cohesion C-terminus<br>Pfam-B_443 (release 24.0). This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.. 
+PF12831 FAD dependent oxidoreductase<br>PfamB_47 (release 24.0). This family of proteins contains FAD dependent oxidoreductases and related proteins.. 
+PF12832 MFS_1 like family<br>Pfam-B_20770 (release 24.0). In fungal members this domain is found at the C-terminus of putative transporter proteins.. 
+PF12833 Helix-turn-helix domain<br>
+PF12834 Integrase_l_N;<br>Phage integrase, N-terminal. Pfam-B_50 (release 24.0). This is a family of DNA-binding prophage integrases. It is found largely in Proteobacteria.. 
+PF12835 Integrase<br>Pfam-B_50 (release 24.0). This is a family of DNA-binding prophage integrases found in Proteobacteria.. 
+PF12836 Helix-hairpin-helix motif<br>The HhH domain is a short DNA-binding domain  .. 
+PF12837 4Fe-4S binding domain<br>This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF12838 4Fe-4S dicluster domain<br>Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.. 
+PF12840 Helix-turn-helix domain<br>This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.. 
+PF12841 YvrJ protein family<br>This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterised.. 
+PF12842 Domain of unknown function (DUF3819)<br>Pfam-B_986 (release 24.0). This is an uncharacterised domain that is found on the CCR4-Not complex component Not1.  Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID  .. 
+PF12843 Protein of unknown function (DUF3820)<br>Pfam-B_72 (release 24.0). This a bacterial family that is functionally uncharacterised.. 
+PF12844 Helix-turn-helix domain<br>Members of this family contains a DNA-binding helix-turn-helix domain.. 
+PF12845 TBD domain<br>The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation  . The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side  .. 
+PF12846 AAA-like domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.. 
+PF12847 Methyltransferase domain<br>Protein in this family function as methyltransferases.. 
+PF12848 ABC transporter<br>This domain is related to Pfam:PF00005.. 
+PF12849 PBP superfamily domain<br>This domain belongs to the periplasmic binding protein superfamily.. 
+PF12850 Calcineurin-like phosphoesterase superfamily domain<br>Members of this family are part of the Calcineurin-like phosphoesterase superfamily.. 
+PF12851 TET_DSBH;<br>Oxygenase domain of the 2OGFeDO superfamily . A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in  various eukaryotes, bacteria and bacteriophages  . Members of this  family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids  , and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine  (hmC)  , or further oxidation to 5-formylcytosine (5fC) and  5-carboxylcytosine (5caC)  . Metazoan TET proteins contain a  cysteine-rich region inserted into the core of the DSBH fold.  Vertebrate TET proteins are oncogenes that are mutated in various  myeloid cancers  . Fungal and algal versions of this family are  linked to a predicted transposase and show lineage-specific  expansions  .. 
+PF12852 Cupin<br>Pfam-B_918 (release 24.0). This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily.  Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.. 
+PF12853 C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit<br>This family is the C-terminal domain of NADH-ubiquinone oxidoreductase 21 kDa subunits from fungi.. 
+PF12854 PPR repeat<br>Pfam-B_105542 (release 24.0). This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. The exact function is not known.. 
+PF12855 Life-span regulatory factor<br>Pfam-B_42039 (release 24.0). This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation.. 
+PF12856 Anaphase-promoting complex subunit 9<br>Apc9 is one of the subunits of the anaphase-promoting complex, or cyclosome  , which is essential for regulating entry into anaphase and exit from mitosis. The APC is a ubiquitin-protein ligase complex. All APC subunits are members of the cullin family proteins, which bind to a ring-finger subunit via a conserved cullin domain  . The APC is made up of four parts, the third of which is a tetratricopeptide repeat arm (TPR) that contains Apc9  .. 
+PF12857 TOBE-like domain<br>Pfam-B_1384 (release 24.0). The TOBE domain   (Transport-associated OB) always occurs  as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately  after the ATPase domain.. 
+PF12859 Anaphase-promoting complex subunit 1<br>Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex  .. 
+PF12860 PAS fold<br>Pfam-B_21375 (release 24.0). The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs  . The PAS fold appears in archaea, eubacteria and eukarya.. 
+PF12861 Anaphase-promoting complex subunit 11 RING-H2 finger<br>Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome  . The APC subunits are cullin family proteins with ubiquitin ligase activity  . Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability  .. 
+PF12862 Anaphase-promoting complex subunit 5<br>Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multi-subunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1.  Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [1,2]. The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC  . This region of the Apc5 member proteins carries a TPR-like motif.. 
+PF12863 Domain of unknown function (DUF3821)<br>This is a domain largely confined to sequences from Methanomicrobiales found on putative lipases. The function is not known.. 
+PF12864 Protein of unknown function (DUF3822)<br>This is a family of uncharacterised bacterial proteins. However, structural-similarity searches indicate the family takes on an actin-like ATPase fold.. 
+PF12866 Protein of unknown function (DUF3823)<br>This is a family of uncharacterised proteins from Bacteroidetes. It has characteristic DN and DR sequence-motifs. The function is not known.. 
+PF12867 DinB superfamily<br>The DinB family are an uncharacterised family of potential enzymes. The structure of these proteins is composed of a four helix bundle  .. 
+PF12868 Domain of unknwon function (DUF3824)<br>This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.. 
+PF12869 tRNA_anti-like<br>JCSG_target_390051_3f1z. This is a family of bacterial, archeael and viral proteins that is related to the tRNA_anti family Pfam:PF01336. The major characteristic of families like tRNA_anti is their OB-fold, and many of them bind DNA.. 
+PF12870 Lumazine-binding domain<br>JCSG_target_391926_3k7c. This is a family of putative lipoproteins from bacteria.  Many members of the family are defined as having a lumazine-binding domain. Lumazine is a fluorescent accessory protein having 6,7-dimethyl-8-(1'-D-ribityl) lumazine (DMRL) as its authentic chromophore; it modulates the emission of bacterial luciferase to shorter wavelengths with increasing luminous strength. The family is related to the NTF2-like transpeptidase family.. 
+PF12871 Pre-mRNA-splicing factor 38-associated hydrophilic C-term<br>This domain is a hydrophilic region found at the C-terminus of plant and metazoan pre-mRNA-splicing factor 38 proteins.  The function is not known.. 
+PF12872 OST_LOTUS;<br>OST-HTH/LOTUS domain. A predicted RNA-binding domain found in insect Oskar and vertebrate TDRD5/TDRD7 proteins that nucleate or organize structurally related ribonucleoprotein (RNP) complexes, the polar granule and nuage, is poorly understood   . The domain adopts the winged helix-turn-  helix fold and bind RNA with a potential specificity for dsRNA  .In  eukaryotes this domain is often combined in the same polypeptide with protein-protein- or lipid- interaction domains that might play a role in anchoring these proteins to specific cytoskeletal structures. Thus, proteins with this domain might have a key role in the recognition and localization of dsRNA, including miRNAs, rasiRNAs and piRNAs hybridized to their targets. In other cases, this domain is fused to ubiquitin-binding, E3 ligase and ubiquitin-like domains indicating a previously under-appreciated role for ubiquitination in regulating the assembly and stability of nuage-like RNP complexes. Both bacteria and eukaryotes encode a conserved family of proteins that combines this predicted RNA-binding domain with a previously uncharacterized RNAse domain belonging to the superfamily that includes the 5'->3' nucleases, PIN and NYN domains  .. 
+PF12873 Domain of unknown function (DUF3825)<br>Potential uncharacterized enzymatic domain associated with bacterial Pfam:PF12872 domains.  Has conserved residues suggestive of an enzymatic role probably related to RNA metabolism.. 
+PF12874 Zinc-finger of C2H2 type<br>This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.. 
+PF12875 Protein of unknown function (DUF3826)<br>JCSG_target_393061_3g6i. This is a putative sugar-binding family.. 
+PF12876 Sugar-binding cellulase-like<br>JCSG_target_394744_3gyc. This is a putative cellulase family.. 
+PF12877 Domain of unknown function (DUF3827)<br>Zenonos ZA, Mistry J. This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34 [1-2].  Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion [1-3].. 
+PF12878 SICA extracellular beta domain<br>The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  There can be between 1 and 10 copies of this cysteine-rich domain  .. 
+PF12879 SICA C-terminal inner membrane domain <br>The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  The C-terminal domain is thought to remain in the erythrocyte, found juxtaposition to the single transmembrane domain.  To date, all full length proteins contain a single copy of this domain  .. 
+PF12881 NUT protein N terminus<br>Zenonos ZA, Mistry J. This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations [1-2]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [1-2]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein [1-2]. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [3-4]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation [3-4].. 
+PF12882 NUT protein C terminal<br>Zenonos ZA, Mistry J. This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations [1-2]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [1-2]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS) [1-2], both located C-terminal to this domain. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [3-4]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation [3-4].. 
+PF12883 Protein of unknown function (DUF3828)<br>JCSG_target_392985_3kzt. This is a family of bacterial proteins of unknown function.. 
+PF12884 Transducer of regulated CREB activity, N terminus<br>Zenonos ZA, Mistry J. This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding)  . The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS)  . The coiled-coil structure interacts with the bZIP domain of CREB  . This interaction may occur via ionic bonds because it is disrupted under high-salt conditions  . In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs  , but the physiological function of the multimeric complex has not been clarified yet.. 
+PF12885 Transducer of regulated CREB activity middle domain<br>Zenonos ZA, Mistry J. This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding)  . Although the C- and N- terminal domains of these proteins have been well characterised [1-2], no functional role has been assigned to the central region, yet.. 
+PF12886 Transducer of regulated CREB activity, C terminus<br>Zenonos ZA, Mistry J. This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding)  . The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs  .. 
+PF12887 SICA extracellular alpha domain<br>The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  This domain is typically found at the N-terminus, with 1 or 2 copies per protein.  The domain is cysteine-rich domain  and similar to PFAM:PF12878  .. 
+PF12888 Lipid-binding putative hydrolase<br>JCSG_target_393040_3h3i. This is a small family of lipid-binding proteins found in Bacteroidetes.. 
+PF12889 Protein of unknown function (DUF3829)<br>JCSG_target_393163_3iee. This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL_GvpF family of proteins, Pfam:PF06386.. 
+PF12890 Dihydro-orotase-like<br>This is a small family of dihydro-orotase-like proteins from various bacteria.. 
+PF12891 Glycoside hydrolase family 44<br>This is a family of bacterial glycoside hydrolases formerly known as cellulase family J, and now known as Cel44A. It is one of the major enzymatic components of the cellulosome of Clostridium thermocellum strain F1 and of many other Firmicutes.. 
+PF12892 T surface-antigen of pili<br>The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages  . The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonisation of human tissues  .. 
+PF12893 Putative lumazine-binding<br>This is a family of uncharacterised proteins. However, the family belongs to the NTF2-like superfamily of various enzymes, and some of the members of the family are putative dehydrogenases.. 
+PF12894 Anaphase-promoting complex subunit 4 WD40 domain<br>Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,. 
+PF12895 Anaphase-promoting complex, cyclosome, subunit 3<br>Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1, 2]. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20  .. 
+PF12896 Anaphase-promoting complex, cyclosome, subunit 4<br>Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle.  the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism  .. 
+PF12897 Alanine-glyoxylate amino-transferase<br>JCSG_target_390749_3ez1. These proteins catalyse the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid  . They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyse this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration  .. 
+PF12898 Stc1 domain<br>The domain contains 8 conserved cysteines that may bind to zinc. In S. pombe this protein acts as a protein linker which links the chromatin modifying CLRC complex to RNAi by tethering it to the RITS complex. The region is reported as a LIM domain here, but has a slightly different arrangement of its CxxC pairs from the Pfam LIM domain Pfam:PF00412, hence why it is not part of that family  . The tandem zinc-finger structure could mediate protein-protein interactions.. 
+PF12899 Alkaline and neutral invertase<br>This is a family of bacterial and plant alkaline and neutral invertases, EC:3.2.1.26, previously known as Invertase_neut Pfam:PF04853.. 
+PF12900 Pyridoxamine 5'-phosphate oxidase<br>Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP).  This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.. 
+PF12901 SUZ-C motif<br>The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.. 
+PF12902 Ferritin-like<br>JCSG_target_390707_3hli. This is a family of bacterial ferritin-like substances that also includes a C-terminal domain of VioB, polyketide synthase enzymes, that make up one of the key components of the violacein biosynthesis pathway. Violacein is a purple-coloured, broad-spectrum antibacterial pigment.. 
+PF12903 Protein of unknown function (DUF3830)<br>JCSG_target_392654_3kop. This is a family of bacterial and archaeal proteins, the structure for one of whose members has been characterised. PDB:3kop from Swiss:A0JVT3 probably adopts a new hexameric form compared to previous structures. The putative active is near the domain interface. 3kop is most closely related, structurally to PDB:1zx8, where the potential active site is located near residues E51 and Y53 (conserved in 1zx8). Beyond the two residues above, the other residues are not conserved. Also the shape of the active site differs from that of 1zx8. PDB:1zx8 belongs to family DUF369. Pfam:PF04126, which is part of the cyclophilin-like clan.. 
+PF12904 Putative collagen-binding domain of a collagenase <br>JCSG_target_393067_3kzs. This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. It is the C-terminal part of the PDB:3kzs structure determined from Swiss:Q8A905 (information derived from TOPSAN).. 
+PF12905 Endo-alpha-N-acetylgalactosaminidase<br>Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.. 
+PF12906 RING-variant domain<br>
+PF12907 Zinc-binding<br>This is small family of metazoan zinc-binding proteins.. 
+PF12909 Protein of unknown function (DUF3832)<br>JCSG_target_391895_3k6q. This is a family of proteins from bacteria and archaea of unknwon function. The N-terminal part of the structure from Swiss:Q0AZ30 shows remote homology to the N-terminus of the bacterial toxin/antitoxin 'addiction module', and the C-terminus is distantly related to the TTHA1013/TTHA0281 superfamily.. 
+PF12910 Antitoxin of toxin-antitoxin stability system N-terminal<br>JCSG_target_391895_3k6q. This domain appears to be the N-terminus of the RelB antitoxin of toxin-antitoxin stability system or prevent-host death system. Together RelE toxin and the RelB antitoxin form a non-toxic complex.  Although toxin-antitoxin gene cassettes were first found in plasmids, it is clear that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria, and these toxin-antitoxin loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress [1,2].. 
+PF12911 N-terminal TM domain of oligopeptide transport permease C<br>Pfam-B_1473 (release 24.0). Oligopeptide permeases (Opp) have been identified in numerous gram-negative and -positive bacteria. These transport systems belong to the superfamily of highly conserved ATP-binding cassette transporters. Typically, Opp importers comprise a complex of five proteins. The oligopeptide-binding protein OppA is responsible for the capture of peptides from the external medium. Two integral highly hydrophobic membrane spanning proteins, OppB and OppC, form a channel through the membrane used for peptide translocation.  This N-terminal domain appears to be the first TM domain of the molecule  .. 
+PF12912 N-term_NLPC_P60;<br>NLPC_P60 stabilising domain, N term. Pfam-B_845 (release 24.0). This domain, at the N-terminus, appears to be the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b1, the third an SH3b2 and the last, the C-terminal region, the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).. 
+PF12913 SH3 domain of the SH3b1 type<br>JCSG_target_405735_3m1u. This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).. 
+PF12914 SH3 domain of SH3b2 type<br>JCSG_target_405735_3m1u. This domain appears to be an SH3 domain of the SH3b2-type, and is the second SH3 domain to be found, downstream of an N-terminal domain that is probably the stabilising domain, for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein.  The last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).. 
+PF12915 Protein of unknown function (DUF3833)<br>Pfam-B_259 (release 24.0). This is a family of uncharacterised proteins found in Proteobacteria.. 
+PF12916 Protein of unknown function (DUF3834)<br>This family is likely to be related to solute-binding lipo-proteins.. 
+PF12917 HD_1;<br>HD containing hydrolase-like enzyme . This is a family of bacterial and archaeal hydrolases.. 
+PF12918 TcdB toxin N-terminal helical domain<br>This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile  . The function of this domain is unknown, but it may be involved in substrate recognition.. 
+PF12919 TcdA/TcdB catalytic glycosyltransferase domain<br>This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein.. 
+PF12920 TcdA/TcdB pore forming domain<br>This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region.. 
+PF12921 Mitochondrial ATPase expression<br>ATP13 is necessary for the expression of subunit 9 of mitochondrial ATPase. The protein has a basic amino terminal signal sequence that is cleaved upon import into mitochondria  .. 
+PF12922 non-SMC mitotic condensation complex subunit 1, N-term<br>Pfam-B_15091 (release 24.0). The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis. This is the conserved N-terminus of the subunit 1.. 
+PF12923 Ribosomal RNA-processing protein 7 (RRP7)<br>Pfam-B_1057 (release 24.0). RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly  .  It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [1-2].. 
+PF12924 Copper-binding of amyloid precursor, CuBD<br>This short domain, part of the extra-cellular N-terminus of the amyloid precursor protein, APP, can bind both copper and zinc, CuBD.  The structure of Cu2+-bound CuBD reveals that the metal ligands are His147, His151, Tyr168 and two water molecules, which are arranged in a square pyramidal geometry. The structure of Cu+-bound CuBD is almost identical to the Cu2+-bound structure except for the loss of one of the water ligands. The geometry of the site is unfavourable for Cu+, thus providing a mechanism by which CuBD could readily transfer Cu ions to other proteins.. 
+PF12925 E2 domain of amyloid precursor protein<br>The E2 domain is the largest of the conserved domains of the amyloid precursor protein. The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix, and bears an unexpected resemblance to the spectrin family of protein structures.E 2 can reversibly dimerise in solution, and the dimerisation occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. The high degree of conservation of residues at the putative dimer interface suggests that the E2 dimer observed in the crystal could be physiologically relevant. Heparin sulfate proteoglycans, the putative ligands for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface  .. 
+PF12926 Mitotic-spindle organizing gamma-tubulin ring associated<br>FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear  .. 
+PF12927 Domain of unknown function (DUF3835)<br>Pfam-B_14632 (release 24.0). This is a C-terminal domain conserved in fungi.. 
+PF12928 tRNA-splicing endonuclease subunit sen54 N-term<br>Pfam-B_644 (release 24.0). This is an N-terminal family of archaeal and metazoan sen54 proteins that forms one of the tRNA-splicing endonuclease subunits.. 
+PF12929 Stretch-activated Ca2+-permeable channel component<br>Pfam-B_1244 (release 24.0). MID1 is a yeast Saccharomyces cerevisiae gene encoding a plasma membrane protein required for Ca2+ influx induced by the mating pheromone, alpha-factor. Mid1 protein plays a crucial role in supplying Ca2+ during the mating process. Mid1 is composed of 548-amino-acid residues with four hydrophobic regions named H1, H2, H3 and H4, and two cysteine-rich regions (C1 and C2) at the C-terminal. This family contains the H3, H4, C1 and C2 regions. suggesting that H1 is a signal sequence responsible for the alpha-factor-induced Mid1 delivery to the plasma membrane. The region from H1 to H3 is required for the localisation of Mid1 in the plasma and ER membranes. Trafficking of Mid1-GFP to the plasma membrane is dependent on the N-glycosylation of Mid1 and the transporter protein Sec12. This findings suggests that the trafficking of Mid1-GFP to the plasma membrane requires a Sec12-dependent pathway from the ER to the Golgi, and that Mid1 is recruited via a Sec6- and Sec7-independent pathway from the Golgi to the plasma membrane.. 
+PF12930 Family of unknown function (DUF3836)<br>Family of uncharacterised proteins found in Bacteroidales species. Test.. 
+PF12931 Sec23-binding domain of Sec16<br>Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure  .. 
+PF12932 Vesicle coat trafficking protein Sec16 mid-region<br>Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway  .. 
+PF12933 FTO catalytic domain<br>This domain is the catalytic AlkB-like domain from the FTO protein  . This domain catalyses a demethylase activity with a preference for 3-methylthymidine.. 
+PF12934 FTO C-terminal domain<br>This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans.  The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure  . This domain is alpha helical with three helices that form a bundle  .. 
+PF12935 Vesicle coat trafficking protein Sec16 N-terminus<br>Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region  .. 
+PF12936 KRI1-like family C-terminal<br>Pfam-B_8372 (release 7.7). The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus  . This is the C-terminal domain of the family.. 
+PF12937 F-box-like<br>Pfam-B_22368 (release 24.0). This is an F-box-like family.. 
+PF12938 M domain of GW182<br>
+PF12939 Domain of unknown function (DUF3837)<br>A small, compact all-alpha helical domain of unknown function. This domain is currently only found in Clostridiales species. . 
+PF12940 Recombination-activation protein 1 (RAG1)<br>This famiy contains recombination activating protein 1, which is the catalytic component of the RAG complex.  The RAG complex is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination  .  RAG1 mediates DNA-binding to the conseved recombination signal sequences (RSS)  .  Many of the proteins in this family are fragments.. 
+PF12941 DUF3838;<br>HCV NS5a protein C-terminal region. This is a family of proteins found in the hepatitis C virus. This family contains the C-terminal region of the NS5A protein.  CC The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525.. 
+PF12942 Archaeal ammonia monooxygenase subunit A (AmoA)<br>This is an archeael family that contains ammonia monooxygenase subunit A.  Ammonia monooxygenase is an enzyme that oxidises ammonia to nitrite and nitrate, thus playing a significant role in the nitrogen cycle.  Ammonia-oxidising archaea (AOA) are widespread in marine environments  .. 
+PF12943 Protein of unknown function (DUF3839)<br>This is a family of uncharacterised proteins that are found in Trichomonas.. 
+PF12944 Protein of unknown function (DUF3840)<br>This is a family of uncharacterised proteins found in hepatitis A viruses.. 
+PF12945 Flagellar protein YcgR<br>Mistry J, Auchincloss A. This domain is found N terminal to Pfam:PF07238.  Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias  .  This family contains members not captured by Pfam:PF07317.. 
+PF12946 MSP1 EGF domain 1<br>This EGF-like domain is found at the C-terminus of the malaria parasite MSP1 protein. MSP1 is the merozoite surface protein 1. This domain is part of the C-terminal fragment that is proteolytically processed from the the rest of the protein and is left attached to the surface of the invading parasite.. 
+PF12947 EGF domain<br>This family includes a variety of EGF-like domain homologues. This family includes the C-terminal domain of the malaria parasite MSP1 protein  .. 
+PF12948 MSP7-like protein C-terminal domain<br>MSP7 is a protein family the malaria parasite that has been found to be associated with processed fragments from the MSP1 protein in a complex involved in red blood cell invasion.. 
+PF12949 SAP_2;<br>Mistry J, Sazer S, Wood V. This is a HeH domain.  HeH domains form helix-extended loop-helix (HeH) structures.\.       This domain is closely related to Pfam:PF03020 and Pfam:PF02037.. 
+PF12950 TaqI-like C-terminal specificity domain<br>This domain is found at the C-terminus of the TaqI protein and is involved in DNA-binding and substrate recognition.. 
+PF12951 Autotransporter-associated beta strand repeat<br>This model represent a core 32-residue region of a class of bacterial protein repeat found in one to 30 copies per protein. Most proteins with a copy of this repeat have domains associated with membrane autotransporters (Pfam:PF03797). The repeats occur with a periodicity of 60 to 100 residues. A pattern of sequence conservation is that every second residue is well-conserved across most of the domain. These repeats as likely to have a beta-helical structure.. 
+PF12952 Domain of unknown function (DUF3841)<br>This presumed domain is around 190 amino acids in length. As yet no function has been given to any member of the family.. 
+PF12953 Domain of unknown function (DUF3842)<br>This short protein is found mainly in firmicute bacteria. It is functionally uncharacterised.. 
+PF12954 Protein of unknown function (DUF3843)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  .. 
+PF12955 Domain of unknown function (DUF3844)<br>This presumed domain is found in fungal species.  It contains 8 largely conserved cysteine residues. This domain is found in proteins that are thought to be found in the endoplasmic reticulum.. 
+PF12956 Domain of Unknown Function with PDB structure<br>JCSG structure PDB:3GF6. Member PDB:3GF6 has statistically significant similarity  to TNF-like jelly roll fold may indicate an immunomodulatory  function  or a bioadhesion role . 
+PF12957 Domain of unknown function (DUF3846)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . This domain is found associated with an Pfam:PF07275 like domain. This suggests that this family may also be involved in evading host restriction.. 
+PF12958 Protein of unknown function (DUF3847)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  .. 
+PF12959 Protein of unknown function (DUF3848)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . This domain frequently seen with DUF3849.. 
+PF12960 Protein of unknown function (DUF3849)<br>JCSG-Joint Centrer for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . This domain frequently seen with DUF3848.. 
+PF12961 Domain of Unknown Function with PDB structure (DUF3850)<br>JCSG structure PDB:3IUW. The search results from NCBI sequence alignment indicates a conserved domain belonging to ASCH superfamily  . Dali searching results show that the protein is a structurally similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia coli.  Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the biomolecule of protein NP_809782.1 should be a dimer.. 
+PF12962 Protein of unknown function (DUF3851)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterised proteins found by clustering human gut metagenomic sequences  .. 
+PF12963 Protein of unknown function (DUF3852)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . This domain frequently seen with DUF3848.. 
+PF12964 Protein of unknown function (DUF3853)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  .. 
+PF12965 Domain of unknown function (DUF3854)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterised proteins found by clustering human gut metagenomic sequences  . This domain is likely to be related to the Toprim domain.. 
+PF12966 N-ATPase, AtpR subunit <br>Membrane protein with three predicted transmembrane segments, two of which contain conserved Arg residues. AtpR genes are found in the N-ATPase (archaeal-type F1-Fo-ATPase) operons and are predicted to interact with the conserved Glu/Asp residues in the c subunits, regulating the assembly and/or function of the membrane-embedded ring of 'c' (proteolipid) subunits (PFAM:PF00137).. 
+PF12967 Domain of Unknown Function with PDB structure (DUF3855)<br>JCSG structure PDB:1O22. Family based on orphan protein (TM0875) from Thermotoga maritima that has been structurally determined as PDB:1022. The TM0875 gene of Thermotoga maritima encodes a hypothetical protein NP_228683   of unknown function. Analysis of TM0875 genomic context reveals the presence of MMT1 (a predicted Co/Zn/Cd cation transporter) and an inactive homolog of metal-dependent proteases. 1O22 shows weak structural similarity with the phosphoribosylformylglycinamidine synthase 1t4a (Dali Z-scr=4.6), the yggU protein (PDB structure:1n91; with DALI Z-scr=3), and with the thioesterase superfamily member (PDB structure 2cy9 - found using FATCAT), even though they have very low sequence identity.. 
+PF12968 Domain of Unknown Function (DUF3856)<br>JCSG structure PDB:2HR2. TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).. 
+PF12969 Domain of Unknown Function with PDB structure (DUF3857)<br>JCSG structure PDB:3KD4. This family is based on the first domain of the PDB structure PDB:3KD4(residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase (3ebi, Z=10, rmsd 3.6A for 152 CA, seq id 12%), despite lack of any significant sequence similarity.. 
+PF12970 Domain of Unknown Function with PDB structure (DUF3858)<br>JCSG structure PDB:3KD4. This family is based on the third domain of the PDB structure 3KD4(residues 410-525).  It is structurally similar to part of neuropilin-2 (Z=4.6, rmsd 3.6A for 83 CA, 7% seq id).  This domain and the second domain appears to be part of peptide-n-glycanase (1x3w, 2g9f).. 
+PF12971 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain<br>Pfam-B_6295 (release 7.7). Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate  . Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations  . The structure shows that the enzyme is composed of three domains.  This N-terminal domain has an alpha-beta fold  .. 
+PF12972 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain<br>Pfam-B_6295 (release 7.7). Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate  . Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations  . The structure shows that the enzyme is composed of three domains.  This C-terminal domain has an all alpha helical fold  .. 
+PF12973 ChrR Cupin-like domain<br>Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.. 
+PF12974 ABC transporter, phosphonate, periplasmic substrate-binding protein <br>This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake.. 
+PF12975 Domain of unknown function (DUF3859)<br>This short domain is functionally uncharacterised.. 
+PF12976 Domain of Unknown Function with PDB structure (DUF3860)<br>JCSG structure PDB:2OD5. A protein family created to cover PDB:2OD5. 2OD5 is a hypothetical protein (JCVI_PEP_1096688149193) from an environmental metagenome (unidentified marine microbe).. 
+PF12977 Domain of Unknown Function with PDB structure (DUF3861)<br>JCSG structure PDB:3CJL. The 3cjl structure is likely a representative of a new fold with some resemblance to 3-helical bundle folds such as the serum albumin-like fold of SCOP. No significant hits reported by a Dali search. This protein is the first structural representative of a small (about 60 proteins) family of proteins that are found among proteo- and enterobacteria (REF http://www.topsan.org/Proteins/JCSG/3CJL).. 
+PF12978 Domain of Unknown Function with PDB structure (DUF3862)<br>JCSG structure PDB:3D4E. PDB:3D4E shared structural similarity to beta-lactamase inhibitory proteins (BLIP) which already include 1XXM, 1S0W, 1JTG, 2G2U, 2G2W, 2B5R, and 3due. All of structures are involved in beta-lactamase inhibitor complex.  (REF http://www.topsan.org/Proteins/JCSG/3d4e). 
+PF12979 Domain of Unknown Function with PDB structure (DUF3863)<br>JCSG structure PDB:3LM3. Domain based on 1-364 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.. 
+PF12980 Domain of Unknown Function with PDB structure (DUF3864)<br>JCSG structure PDB:3LM3. Domain based on 366-449 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.. 
+PF12981 Domain of Unknown Function with PDB structure (DUF3865)<br>JCSG structure PDB:3B5P. Family based of PDB:3B5P encoded by ZP_00108531 from nitrogen-fixing cyanobacterium Nostoc punctiforme pcc 73102 is a CADD-like protein of unknown function. Superposition between protein structures encoded by CT610 from Chlamydia trachomatis (PDB code 1rwc), pyrroloquinolinquinone synthase C (PqqC, PDB code 1otv) and ZP_00108531 revealed that putative active sites in CT610 and ZP_00108531 are identical. ( REF: http://www.topsan.org/Proteins/JCSG/3B5P).. 
+PF12982 Protein of unknown function (DUF3866)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 352 and 374 amino acids in length.. 
+PF12983 Protein of unknown function (DUF3867)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.. 
+PF12984 Domain of unknown function, B. Theta Gene description (DUF3868)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_1065. Based on Bacteroides thetaiotaomicron gene BT_1065, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12985 Domain of unknown function (DUF3869)<br>Ellrott K, Bakolitsa C. JCSG structure PDB:3KOG. A family based on the N-terminal domain of 3KOG, which shows weak but consistent remote homology with adhesive families such as immunoglobulins and cadherins, suggesting it might form an attachment module.. 
+PF12986 Domain of unknown function (DUF3870)<br>Ellrott K, Bakolitsa C. JCSG structure PDB:3KOG. A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins   , suggesting it may have a lytic function. . 
+PF12987 Domain of unknown function, B. Theta Gene description (DUF3871)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_2984. Based on Bacteroides thetaiotaomicron gene BT_2984, a putative uncharacterized protein  As seen in gene expression experiments  (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12988 Domain of unknown function, B. Theta Gene description (DUF3872)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_2593. Based on Bacteroides thetaiotaomicron gene BT_2593, a conserved protein found in a conjugate transposon. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12989 Domain of unknown function, B. Theta Gene description (DUF3873)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_2286. Based on Bacteroides thetaiotaomicron gene BT_2286, a putative uncharacterized protein.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12990 Domain of unknonw function from B. Theta Gene description (DUF3874)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_4228. Based on Bacteroides thetaiotaomicron gene BT_4228, a putative uncharacterized protein  As seen in gene expression experiments  (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12991 Domain of unknown function, B. Theta Gene description (DUF3875)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_4769. Based on Bacteroides thetaiotaomicron gene BT_4769, a conserved protein found in a conjugate transposon. As seem in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12992 Domain of unknown function, B. Theta Gene description (DUF3876)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_0092. Based on Bacteroides thetaiotaomicron gene BT_0092, a conserved protein found in a conjugate transposon. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].. 
+PF12993 Domain of unknown function, E. rectale Gene description (DUF3877)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: EUBREC_0237. Based on Eubacterium rectale gene EUBREC_0237.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture  .. 
+PF12994 Domain of unknown function, E. rectale Gene description (DUF3878)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: EUBREC_0973. Based on Eubacterium rectale gene EUBREC_0973. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737). it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture  .. 
+PF12995 Domain of unknown function, E. rectale Gene description (DUF3879)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: EUBREC_1343. Based on Eubacterium rectale gene EUBREC_1343.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture  .. 
+PF12996 DUF based on E. rectale Gene description (DUF3880)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: EUBREC_3218. Based on Eubacterium rectale gene EUBREC_3218.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737),  It appears to be upregulated in the presence of  Bacteroides thetaiotaomicron vs when isolated in culture  .. 
+PF12997 Domain of unknown function, E. rectale Gene description (DUF3881)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: EUBREC_3695. Based on Eubacterium rectale gene EUBREC_3695.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture  .. 
+PF12998 Inhibitor of growth proteins N-terminal histone-binding<br>Pfam-B_205 (release 24.0). Histones undergo numerous post-translational modifications, including acetylation and methylation, at residues which are then probable docking sites for various chromatin remodelling complexes. Inhibitor of growth proteins (INGs) specifically bind to residues that have been thus modified. INGs carry a well-characterised C-terminal PHD-type zinc-finger domain, binding with lysine 4-tri-methylated histone H3 (H3K4me3), as well as this N-terminal domain that binds unmodified H3 tails. Although these two regions can bind histones independently, together they increase the apparent association of the ING for the H3 tail.. 
+PF12999 Glucosidase II beta subunit-like<br>The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing  . The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum  .. 
+PF13000 Acetyl-coenzyme A transporter 1<br>The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.. 
+PF13001 Proteasome stabiliser<br>Pfam-B_682 (release 24.0). The proteasome consists of two subunits, and the capacity of the proteasome to degrade protein depends crucially on the interaction between these two subunits. This interaction is affected by a wide range of factors including metabolites, such as ATP, and proteasome-associated proteins such as Ecm29. Ecm29 stabilises the interaction between the two subunits.. 
+PF13002 Arrestin_N terminal like<br>This is a family of proteins related to the Arrestin_N terminal family.. 
+PF13003 Ribosomal protein L1<br>This family includes putative ribosomal L1 and L10 proteins and fragments.. 
+PF13004 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal<br>The BACON (Bacteroidetes-Associated Carbohydrate-binding Often N-terminal) domain is an all-beta domain found in diverse architectures, principally in combination with carbohydrate-active enzymes and proteases. These architectures suggest a carbohydrate-binding function which is also supported by the nature of BACON's few conserved amino-acids. The phyletic distribution of BACON and other data tentatively suggest that it may frequently function to bind mucin.. 
+PF13005 HTH_Tnp_IS66;<br>zinc-finger binding domain of transposase IS66 . This is a zinc-finger region of the N-terminus of the insertion element IS66 transposase.. 
+PF13006 Insertion element 4 transposase N-terminal<br>This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), Pfam:PF01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain  .. 
+PF13007 Transposase C of IS166 homeodomain<br>This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.. 
+PF13008 Zinc-binding domain of Paramyxoviridae V protein<br>The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT  . The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction  . In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation  .  The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced.. 
+PF13009 Putative phage integrase<br>Pfam-B_5288 (release 24.0). This family is found in association with IS elements.. 
+PF13010 Primase helical domain<br>This alpha helical domain is found in a set of bacterial plasmid replication proteins  . The domain is found to the C-terminus of the primase/polymerase domain. Mutants of this domain are defective in template binding, dinucleotide formation and conformation change prior to DNA extension  .. 
+PF13011 leucine-zipper of insertion element IS481<br>This is the upstream region of the conjoined ORF AB of insertion element 481. The significance of IS481 in the detection of Bordetella pertussis is discussed in  . The B portion of the ORF AB carries the transposase activity in family rve, PFAM:PF00665.. 
+PF13012 Maintenance of mitochondrial structure and function<br>This is C-terminal to the Mov24 region of the yeast proteasomal subunit Rpn11 and seems likely to regulate the mitochondrial fission and tubulation processes, ie the outer mitochondrial membrane proteins. This function appears to be unrelated to the proteasome activity of the N-terminal region  .. 
+PF13013 F-box-like domain<br>The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.. 
+PF13014 KH domain<br>KH motifs bind RNA in vitro  . This RNA-binding domain is required for the efficient anchoring of ASH1-mRNA to the distal tip of the daughter cell. ASH1 is a specific repressor of transcription that localizes asymmetrically to the daughter cell nucleus.  RNA localisation is a widespread mechanism for achieving localised protein synthesis  .. 
+PF13015 Glucosidase II beta subunit-like protein<br>The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing  . The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum  . The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit  .. 
+PF13016 Cys-rich Gliadin N-terminal<br>This is a cysteine-rich N-terminal region of gliadin and avenin plant proteins. The exact function is not known.. 
+PF13017 piRNA pathway germ-plasm component<br>Maelstrom is a germ-plasm component protein, that is shown to be functionally involved in the piRNA pathway. It is conserved throughout Eukaryota, though it appears to have been lost from all examined teleost fish species.  The domain architecture shows that it is coupled with several DNA- and RNA- related domains such as HMG box, SR-25-like and HDAC_interact domains.  Sequence analysis and fold recognition have found a distant similarity between Maelstrom domain and the DnaQ 3'-5' exonuclease family with the RNase H fold (Exonuc_X-T, Pfam:PF00929); notably, that the Maelstrom domains from basal eukaryotes contain the conserved 3'-5' exonuclease active site residues (Asp-Glu-Asp-His-Asp, DEDHD). However, the animal and some amoeba maelstrom contain another set of conserved residues (Glu-His-His-Cys-His-Cys, EHHCHC). This evolutionary link together with structural examinations leads to the hypothesis that Maelstrom domains may have a potential nuclease-transposase activity or RNA-binding ability that may be implicated in piRNA biogenesis. A protein function evolution mode, namely "active site switch", has been proposed  , in which the amoeba Maelstrom domains are the possible evolutionary intermediates due to their harbouring of the specific characteristics of both 3'-5' exonuclease and Maelstrom domains.. 
+PF13018 Extended Signal Peptide of Type V secretion system<br>Coggill P, Desvaux M. This conserved domain is called ESPR for Extended Signal Peptide Region. It is present at the N-terminus of the signal peptides of proteins belonging to the Type V secretion systems, including the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (TAAs). So far, the ESPR is present only in Gram-negative bacterial proteins originating from the classes Beta- and Gamma-proteobacteria. ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation. Deletion of ESPR causes mis-folding of the TAAs passenger domain in the periplasm , substantially impairing its translocation across the outer membrane  .. 
+PF13019 Ubiquitin-like;<br>Telomere stability and silencing. Pfam-B_2457 (release 24.0). Sde2 has been identified in fission yeast as an important factor in telomere formation and maintenance. This is a more N-terminal domain on these nuclear proteins, and is essential for telomeric silencing and genomic stability.. 
+PF13020 Domain of unknown function (DUF3883)<br>This is a domain is uncharacterised.  It is found on restriction endonucleases.. 
+PF13021 Domain of unknown function (DUF3885)<br>Pfam-B_1173 (release 24.0). A putative Rac prophage DNA binding protein. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YDDRG sequence motif. There is a single completely conserved residue D that may be functionally important.. 
+PF13022 Helix-turn-helix of insertion element transposase<br>This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.. 
+PF13023 HD domain<br>HD domains are metal dependent phosphohydrolases.. 
+PF13024 Protein of unknown function (DUF3884)<br>Pfam-B_1352 (release 24.0). This family of proteins is functionally uncharacterised. However several proteins are annotated as Tagatose 1,6-diphosphate aldolase, but evidence to support this could not be found. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 106 amino acids in length. There are two completely conserved residues (Y and F) that may be functionally important.. 
+PF13025 Protein of unknown function (DUF3886)<br>Pfam-B_1536 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved L residues that may be functionally important.. 
+PF13026 Protein of unknown function (DUF3887)<br>Pfam-B_1534 (release 24.0). This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 128 and 167 amino acids in length. The proteins in this family contain an N-terminal lipid attachment site.. 
+PF13027 Protein of unknown function (DUF3888)<br>Pfam-B_1080 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 111 and 149 amino acids in length.. 
+PF13028 Protein of unknown function (DUF3889)<br>Pfam-B_1146 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (A and Y) that may be functionally important.. 
+PF13029 Domain of unknown function (DUF3890)<br>Pfam-B_1148 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 70 amino acids in length.. 
+PF13030 Protein of unknown function (DUF3891)<br>Pfam-B_1216 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.. 
+PF13031 Protein of unknown function (DUF3892)<br>Pfam-B_1252 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 87 and 104 amino acids in length.. 
+PF13032 Domain of unknown function (DUF3893)<br>Pfam-B_1590 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 123 and 144 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF13033 Protein of unknown function (DUF3894)<br>Pfam-B_1594 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 79 amino acids in length. There are two conserved sequence motifs: FNIC and MALLNLT.. 
+PF13034 Protein of unknown function (DUF3895)<br>Pfam-B_1598 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (Y and L) that may be functionally important.. 
+PF13035 Protein of unknown function (DUF3896)<br>Pfam-B_1603 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13036 Protein of unknown function (DUF3897)<br>This is a bacterial family of uncharacterised proteins.   Some of the proteins in this family are annotated as putative lipoproteins.. 
+PF13037 Domain of unknown function (DUF3898)<br>Pfam-B_1179 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length. There are two conserved sequence motifs: DFG and FEKG.. 
+PF13038 Domain of unknown function (DUF3899)<br>Pfam-B_1174 (release 24.0). Putative Tryptophanyl-tRNA synthetase.. 
+PF13039 Protein of unknown function (DUF3900)<br>Pfam-B_1279 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 360 amino acids in length.. 
+PF13040 Protein of unknown function (DUF3901)<br>Pfam-B_1316 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a single completely conserved residue L that may be functionally important.. 
+PF13041 PPR repeat family <br>This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins.\.   The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR  .. 
+PF13042 Protein of unknown function (DUF3902)<br>Pfam-B_1357 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a conserved LGI sequence motif.. 
+PF13043 Domain of unknown function (DUF3903)<br>Pfam-B_1600 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.. 
+PF13044 Protein of unknown function (DUF3904)<br>Pfam-B_1386 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in viruses. Proteins in this family are typically between 437 and 448 amino acids in length.. 
+PF13045 Protein of unknown function (DUF3905)<br>Pfam-B_1447 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.. 
+PF13046 Protein of unknown function (DUF3906)<br>Pfam-B_1532 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved EKK sequence motif.. 
+PF13047 Protein of unknown function (DUF3907)<br>Pfam-B_1274 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length. There is a conserved AYTG sequence motif.. 
+PF13048 Protein of unknown function (DUF3908)<br>Pfam-B_1533 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 140 amino acids in length. There is a single completely conserved residue Y that may be functionally important.. 
+PF13049 Protein of unknown function (DUF3910)<br>Pfam-B_1539 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.. 
+PF13050 Protein of unknown function (DUF3911)<br>Pfam-B_1540 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13051 Protein of unknown function (DUF3912)<br>Pfam-B_1615 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13052 Protein of unknown function (DUF3913)<br>Pfam-B_1619 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13053 Protein of unknown function (DUF3914)<br>Pfam-B_1562 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two conserved sequence motifs: KFDIR and DLW.. 
+PF13054 Protein of unknown function (DUF3915)<br>Pfam-B_1549 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF13055 Protein of unknown function (DUF3917)<br>Pfam-B_1608 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.. 
+PF13056 Protein of unknown function (DUF3918)<br>Pfam-B_1567 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two completely conserved residues (G and R) that may be functionally important.. 
+PF13057 Protein of unknown function (DUF3919)<br>Pfam-B_1479 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 262 amino acids in length. There is a conserved YLNG sequence motif.. 
+PF13058 Protein of unknown function (DUF3920)<br>Pfam-B_1595 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.. 
+PF13059 Protein of unknown function (DUF3992)<br>Pfam-B_1628 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 87 and 98 amino acids in length.. 
+PF13060 Protein of unknown function (DUF3921)<br>Pfam-B_1624 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13061 Protein of unknown function (DUF3923)<br>Pfam-B_1586 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13062 Protein of unknown function (DUF3924)<br>Pfam-B_1601 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13063 Protein of unknown function (DUF3925)<br>Pfam-B_1644 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.. 
+PF13064 Protein of unknown function (DUF3927)<br>Pfam-B_1668 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 50 amino acids in length. There is a conserved SVL sequence motif. There is a single completely conserved residue D that may be functionally important.. 
+PF13065 Protein of unknown function (DUF3928)<br>Pfam-B_1675 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.. 
+PF13066 Protein of unknown function (DUF3929)<br>Pfam-B_1716 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.. 
+PF13067 Protein of unknown function (DUF3930)<br>Pfam-B_1721 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 51 and 67 amino acids in length.. 
+PF13068 Protein of unknown function (DUF3932)<br>Pfam-B_1731 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13069 Protein of unknown function (DUF3933)<br>Pfam-B_1720 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13070 Protein of unknown function (DUF3934)<br>Pfam-B_1719 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two conserved sequence motifs: GTG and SKG.. 
+PF13071 Protein of unknown function (DUF3935)<br>Pfam-B_1715 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two conserved sequence motifs: FVF and LGV.. 
+PF13072 Protein of unknown function (DUF3936)<br>Pfam-B_1705 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue G that may be functionally important.. 
+PF13073 Protein of unknown function (DUF3937)<br>Pfam-B_1711 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13074 Protein of unknown function (DUF3938)<br>Pfam-B_1607 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.. 
+PF13075 Protein of unknown function (DUF3939)<br>Pfam-B_1535 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.. 
+PF13076 Protein of unknown function (DUF3940)<br>Pfam-B_1673 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 50 amino acids in length.. 
+PF13077 Protein of unknown function (DUF3909)<br>Pfam-B_1537 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.. 
+PF13078 Protein of unknown function (DUF3942)<br>Pfam-B_1722 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.. 
+PF13079 Protein of unknown function (DUF3916)<br>Pfam-B_1564 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a single completely conserved residue S that may be functionally important.. 
+PF13080 Protein of unknown function (DUF3926)<br>Pfam-B_1663 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 46 and 63 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF13081 Domain of unknown function (DUF3941)<br>Pfam-B_1728 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 30 amino acids in length. There is a conserved YSK sequence motif.. 
+PF13082 Protein of unknown function (DUF3931)<br>Pfam-B_1734 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13083 KH domain<br>
+PF13084 Domain of unknown function (DUF3943)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.. 
+PF13085 2Fe-2S iron-sulfur cluster binding domain<br>The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.. 
+PF13086 AAA domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.. 
+PF13087 AAA domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.. 
+PF13088 BNR repeat-like domain<br>This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.. 
+PF13089 Polyphosphate kinase N-terminal domain<br>Splitting PF02503 into domains. Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.. 
+PF13090 Polyphosphate kinase C-terminal domain<br>Splitting PF02503 into domains. Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. This C-terminal domain has a structure similar to phospholipase D.. 
+PF13091 PLD-like domain<br>
+PF13092 Kinetochore complex Sim4 subunit Fta1<br>CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC  . Fta1 is the equivalent component of the fission yeast Sim4 complex  . The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.. 
+PF13093 CENP-U;<br>Kinetochore complex Fta4 of Sim4 subunit, or CENP-50. Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1  .. 
+PF13094 CENP-Q, a CENPA-CAD centromere complex subunit<br>CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC  . Fta7 is the equivalent component of the fission yeast Sim4 complex  .. 
+PF13095 Kinetochore Sim4 complex subunit FTA2<br>Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1  . The equivalent higher eukaryotic protein is CENP-P. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC  .. 
+PF13096 ShortName;<br>CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P. CENP-P is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC  . Fta7 is the equivalent component of the fission yeast Sim4 complex  .. 
+PF13097 CENP-A nucleosome associated complex (NAC) subunit<br>CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC  . FTA4 is the equivalent component of the fission yeast Sim4 complex. . 
+PF13098 Thioredoxin-like domain<br>
+PF13099 Domain of unknown function (DUF3944)<br>This short domain is sometimes found N terminal to Pfam:PF03981.. 
+PF13100 OstA-like protein<br>This is a family of OstA-like proteins that are related to  Pfam:PF03968.. 
+PF13101 Protein of unknown function (DUF3945)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . This is a C-terminal repeated region.. 
+PF13102 DUF3946;<br>Phage integrase SAM-like domain. JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . This family appears related to the N-terminal domain of phage integrases.. 
+PF13103 TonB C terminal<br>This family contains TonB members that are not captured by Pfam:PF03544.. 
+PF13104 Protein of unknown function (DUF3956)<br>Pfam-B_1228 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.. 
+PF13105 Protein of unknown function (DUF3959)<br>Pfam-B_1424 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 260 amino acids in length.. 
+PF13106 Domain of unknown function (DUF3961)<br>Pfam-B_1483 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 40 amino acids in length.. 
+PF13107 Protein of unknown function (DUF3964)<br>Pfam-B_1516 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two conserved sequence motifs: FYF and AFW.. 
+PF13108 Protein of unknown function (DUF3969)<br>Pfam-B_1576 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.. 
+PF13109 AsmA-like C-terminal region<br>Jackhammer-O25308 (H pylori). This family is similar to the C-terminal of the AsmA protein of E. coli.. 
+PF13110 Protein of unknown function (DUF3966)<br>Pfam-B_1525 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 86 amino acids in length.. 
+PF13111 Protein of unknown function (DUF3962)<br>Pfam-B_1505 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 233 and 796 amino acids in length. There is a conserved FSY sequence motif.. 
+PF13112 Protein of unknown function (DUF3965)<br>Pfam-B_1524 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 380 amino acids in length.. 
+PF13113 Protein of unknown function (DUF3970)<br>Pfam-B_1596 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved NPKY sequence motif.. 
+PF13114 RecO N terminal<br>This entry contains members that are not captured by  Pfam:PF11967.. 
+PF13115 YtkA-like<br>
+PF13116 Protein of unknown function<br>Jackhammer_O25308 (H.pylori). Some members of this family are related to the AsmA family proteins.. 
+PF13117 Cag pathogenicity island protein Cag12<br>This is a Proteobacterial family of Cag pathogenicity island proteins.. 
+PF13118 Protein of unknown function (DUF3972) <br>This is a Proteobacterial family of unknown function.  Some of the proteins in this family are annotated as being kinesin-like proteins.. 
+PF13119 Domain of unknown function (DUF3973)<br>Pfam-B_1636 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YCI sequence motif.. 
+PF13120 Domain of unknown function (DUF3974)<br>Pfam-B_1643 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length.. 
+PF13121 Domain of unknown function (DUF3976)<br>Pfam-B_1743 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.. 
+PF13122 Protein of unknown function (DUF3977)<br>Pfam-B_1744 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13123 Protein of unknown function (DUF3978)<br>Pfam-B_1745 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.. 
+PF13124 Protein of unknown function (DUF3963)<br>Pfam-B_1512 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 85 amino acids in length. There is a conserved DIQKW sequence motif.. 
+PF13125 Protein of unknown function (DUF3958)<br>Pfam-B_1404 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There are two conserved sequence motifs: RLF and TWH.. 
+PF13126 Protein of unknown function (DUF3975)<br>Pfam-B_1736 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.. 
+PF13127 Protein of unknown function (DUF3955)<br>Pfam-B_966 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 68 and 87 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.. 
+PF13128 Protein of unknown function (DUF3954)<br>Pfam-B_934 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length.. 
+PF13129 Protein of unknown function (DUF3953)<br>Pfam-B_875 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 76 amino acids in length.. 
+PF13130 Domain of unknown function (DUF3952)<br>Pfam-B_704 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length. There is a conserved VMSAS sequence motif.. 
+PF13131 Protein of unknown function (DUF3951)<br>Pfam-B_698 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 56 and 71 amino acids in length. There is a conserved YTP sequence motif.. 
+PF13132 Domain of unknown function (DUF3950)<br>Pfam-B_688 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 30 amino acids in length. There is a conserved NFS sequence motif.. 
+PF13133 Protein of unknown function (DUF3949)<br>Pfam-B_636 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 69 and 87 amino acids in length.. 
+PF13134 Protein of unknown function (DUF3948)<br>Pfam-B_550 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.. 
+PF13135 Protein of unknown function (DUF3947)<br>Pfam-B_493 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13136 Protein of unknown function (DUF3984)<br>Pfam-B_3236 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 393 and 442 amino acids in length.. 
+PF13137 Protein of unknown function (DUF3983)<br>Pfam-B_2658 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 40 amino acids in length. There is a conserved AWRN sequence motif.. 
+PF13138 Protein of unknown function (DUF3982)<br>Pfam-B_2022 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 73 amino acids in length. There are two conserved sequence motifs: EKL and EIP.. 
+PF13139 Domain of unknown function (DUF3981)<br>Pfam-B_1754 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.. 
+PF13140 Domain of unknown function (DUF3980)<br>Pfam-B_1748 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length.. 
+PF13141 Protein of unknown function (DUF3979)<br>Pfam-B_1747 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF13142 Domain of unknown function (DUF3960)<br>Pfam-B_1431 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 72 and 89 amino acids in length.. 
+PF13143 Protein of unknown function (DUF3986)<br>Pfam-B_362 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.. 
+PF13144 SAF-like<br>The members of this family are similar to those in the SAF family, and include flagellar basal-body proteins and pilus-assembly proteins.. 
+PF13145 PPIC-type PPIASE domain<br>
+PF13146 TRL-like protein family<br>This family includes the Swiss:O87326 TRL protein that is found in a locus that includes several tRNAs.  The function of this protein is not known  . The proteins in this family usually have a lipoprotein attachment site at their N-terminus.. 
+PF13147 Amidohydrolase<br>This family of enzymes are a part of a large metal dependent hydrolase superfamily  . The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source  . This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit  . Dihydroorotases (EC:3.5.2.3) are also included [4-5].. 
+PF13148 Protein of unknown function (DUF3987)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterised proteins found by clustering human gut metagenomic sequences  .. 
+PF13149 Protein of unknown function (DUF3988)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterised proteins found by clustering human gut metagenomic sequences  .. 
+PF13150 Protein of unknown function (DUF3989)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterised proteins found by clustering human gut metagenomic sequences  .. 
+PF13151 Protein of unknown function (DUF3990)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterised proteins found by clustering human gut metagenomic sequences  .. 
+PF13152 Protein of unknown function (DUF3967)<br>Pfam-B_1529 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 249 amino acids in length.. 
+PF13153 Protein of unknown function (DUF3985)<br>Pfam-B_3329 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.. 
+PF13154 Protein of unknown function (DUF3991)<br>This family of proteins is often associated with family Toprim, Pfam:PF01751.. 
+PF13155 Toprim-like<br>This is a family or Toprim-like proteins.. 
+PF13156 Restriction endonuclease<br>Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2]. 
+PF13157 Protein of unknown function (DUF3992)<br>Pfam-B_480 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 98 and 122 amino acids in length. There is a single completely conserved residue T that may be functionally important.. 
+PF13158 Protein of unknown function (DUF3993)<br>Pfam-B_782 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.. 
+PF13159 Domain of unknown function (DUF3994)<br>Pfam-B_903 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 97 and 111 amino acids in length.. 
+PF13160 Protein of unknown function (DUF3995)<br>Pfam-B_958 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 138 and 149 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.. 
+PF13161 Protein of unknown function (DUF3996)<br>Pfam-B_998 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 203 amino acids in length.. 
+PF13162 Protein of unknown function (DUF3997)<br>Pfam-B_1597 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.. 
+PF13163 Protein of unknown function (DUF3999)<br>Pfam-B_2128 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 440 and 470 amino acids in length. There is a single completely conserved residue D that may be functionally important.. 
+PF13164 Protein of unknown function (DUF4002)<br>Pfam-B_3350 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 112 and 125 amino acids in length. There are two completely conserved C residues that may be functionally important.. 
+PF13165 Protein of unknown function (DUF4001)<br>Pfam-B_3337 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are at least two pairs of cysteine residues in this short family of proteins.. 
+PF13166 AAA domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease  .. 
+PF13167 GTP-binding GTPase N-terminal<br>This is the N-terminal region of GTP-binding HflX-like proteins. The full-length members bind and interact with the 50S ribosome and are GTPases, hydrolysing GTP/GDP/ATP/ADP. This N-terminal region is necessary for stability of the whole protein.. 
+PF13168 Poxvirus B22R protein C-terminal<br>Pfam-B_3510 (release 7.3). This is the highly conserved C-terminal region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.. 
+PF13169 Poxvirus B22R protein N-terminal<br>Pfam-B_3510 (release 7.3). This is the highly conserved N-terminal region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.. 
+PF13170 Protein of unknown function (DUF4003)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 345 amino acids in length.. 
+PF13171 Protein of unknown function (DUF4004)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 210 amino acids in length.. 
+PF13172 PepSY-associated TM helix<br>This family represents a conserved TM helix found in bacteria and archaea.. 
+PF13173 AAA domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.. 
+PF13174 Tetratricopeptide repeat<br>
+PF13175 AAA ATPase domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.. 
+PF13176 Tetratricopeptide repeat<br>
+PF13177 DNA polymerase III, delta subunit<br>DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction  . The delta subunit is also known as HolA.. 
+PF13178 Protein of unknown function (DUF4005)<br>Pfam-B_2171 (release 24.0). This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.. 
+PF13179 Family of unknown function (DUF4006)<br>This is a family of short, approx 65 residue-long, bacterial proteins of unknown function.. 
+PF13180 PDZ domain<br>
+PF13181 Tetratricopeptide repeat<br>
+PF13182 Protein of unknown function (DUF4007)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 284 and 326 amino acids in length. This domain is found associated with Pfam:PF01507 in some proteins, suggesting a functional link.. 
+PF13183 4Fe-4S dicluster domain<br>Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.. 
+PF13184 NusA-like KH domain<br>
+PF13185 GAF domain<br>
+PF13186 DUF4008;<br>Iron-sulfur cluster-binding domain. This domain occurs as an additional C-terminal iron-sulfur cluster binding domain in many radical SAM domain, Pfam:PF04055 proteins. The domain occurs in a number of proteins that modify a protein to become an active enzyme, or a peptide to become a ribosomal natural product. The domain is named SPASM because it occurs in the maturases of Subilitosin, PQQ, Anaerobic Sulfatases, and Mycofactocin.. 
+PF13187 4Fe-4S dicluster domain<br>
+PF13188 PAS domain<br>
+PF13189 Cytidylate kinase-like family<br>This family includes enzymes related to cytidylate kinase.. 
+PF13190 PDGLE domain<br>This short presumed domain is usually found on its own. However, it is also found associated with Pfam:PF01891 suggesting it may have a role in cobalt uptake. The domain is named after a short motif found within many members of the family.. 
+PF13191 AAA ATPase domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.. 
+PF13192 Thioredoxin domain<br>
+PF13193 DUF4009;<br>AMP-binding enzyme C-terminal domain. Mistry J, Eberhardt R. This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.. 
+PF13194 Domain of unknown function (DUF4010)<br>This is a family of putative membrane proteins found in archaea and bacteria.\.  It is sometimes found C terminal to Pfam:PF02308.. 
+PF13195 Protein of unknown function (DUF4011)<br>This family of proteins is found in archaea and bacteria. Many members are annotated as being putative DNA helicase-related proteins.. 
+PF13196 Protein of unknown function (DUF4012)<br>This is a family of uncharacterised proteins found in archaea and bacteria.. 
+PF13197 Protein of unknown function (DUF4013)<br>This is a family of uncharacterised proteins that is found in archaea and bacteria.. 
+PF13198 Protein of unknown function (DUF4014)<br>Pfam-B_4873 (release 24.0). This is a bacterial and viral family of uncharacterised proteins.. 
+PF13199 Glycosyl hydrolase family 66<br>Pfam-B_3959 (Release 24.0). This family is a set of glycosyl hydrolase enzymes including cycloisomaltooligosaccharide glucanotransferase (EC:2.4.1.-) and dextranase (EC:3.2.1.11) activities.. 
+PF13200 Putative glycosyl hydrolase domain<br>Pfam-B_597 (Release 24.0). This domain is related to other known glycosyl hydrolases suggesting this domain is also involved in carbohydrate break down.. 
+PF13201 Putative glycoside hydrolase xylanase<br>This is a family of putative bacterial xylanases. Comparative structural data from TOPSAN indicates there to be a C-terminal carbohydrate binding domain similar to those of carbohydrate enzymes such as glucanase and xylanase. There is also structural similarity of the N-terminal domain, according to TOPSAN, to endo-1,4-beta-xylanase (from Streptomyces sviceus) and beta-xylosidase (from Magnetospirillum magnetotacticum MS-1). The N-terminal domain fold is an immunoglobulin-like beta-sandwich.. 
+PF13202 EF_hand_3;<br>
+PF13203 Putative metallopeptidase domain<br>This domain, found in various hypothetical bacterial proteins, has no known function. However, it is related to Pfam:PF01435.. 
+PF13204 Hydrolase_6;<br>Protein of unknown function (DUF4038). A family of putative cellulases. . 
+PF13205 Bacterial Ig-like domain<br>
+PF13206 Trypanosomal VSG domain<br>This family represents the B-type variant surface glycoproteins from trypanosomal parasites. This family is related to Pfam:PF00913.. 
+PF13207 AAA domain<br>
+PF13208 DUF4016;<br>Anantharaman V, Aldam G, Mistry J. The TerB-N domain is found N terminus to TerB, and TerB-C containing proteins  . It has a predominantly alpha-helical structure and contains an absolutely conserved glutamate  . The presence of a conserved acidic residue suggests that it might chelate metal like TerB  . These proteins occur in an two-gene operon containing an AAA+ ATPase and SF-II DNA helicase suggesting a role in stress  stress response or phage defense  .. 
+PF13209 Protein of unknown function (DUF4017)<br>Pfam-B_2009 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13210 Domain of unknown function (DUF4018)<br>Pfam-B_2010 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 190 amino acids in length.. 
+PF13211 Protein of unknown function (DUF4019)<br>Pfam-B_2012 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 130 and 183 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF13212 Domain of unknown function (DUF4020)<br>Pfam-B_2014 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 176 and 195 amino acids in length.. 
+PF13213 Protein of unknown function (DUF4021)<br>Pfam-B_2025 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved YGM sequence motif.. 
+PF13214 Protein of unknown function (DUF4022)<br>Pfam-B_2027 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 85 amino acids in length.. 
+PF13215 Protein of unknown function (DUF4023)<br>Pfam-B_2030 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved KLP sequence motif.. 
+PF13216 Protein of unknown function (DUF4024)<br>Pfam-B_2031 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved RDE sequence motif.. 
+PF13217 Protein of unknown function (DUF4025)<br>Pfam-B_2033 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved EGT sequence motif.. 
+PF13218 Protein of unknown function (DUF4026)<br>Pfam-B_2037 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 450 amino acids in length. The family is found in association with Pfam:PF10077.. 
+PF13219 Protein of unknown function (DUF4027)<br>Pfam-B_2038 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved CLGGF sequence motif.. 
+PF13220 Protein of unknown function (DUF4028)<br>Pfam-B_2040 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 67 and 93 amino acids in length. There are two conserved sequence motifs: IVKI and YVKKWF.. 
+PF13221 Protein of unknown function (DUF4029)<br>Pfam-B_2041 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 119 amino acids in length.. 
+PF13222 Protein of unknown function (DUF4030)<br>Pfam-B_2044 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 197 amino acids in length.. 
+PF13223 Protein of unknown function (DUF4031)<br>Pfam-B_2059 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.. 
+PF13224 Domain of unknown function (DUF4032)<br>Pfam-B_2062 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 170 amino acids in length. The family is found in association with Pfam:PF06293.. 
+PF13225 Domain of unknown function (DUF4033)<br>Pfam-B_2072 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length.. 
+PF13226 Domain of unknown function (DUF4034)<br>Pfam-B_2075 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 280 amino acids in length. There is a conserved PRW sequence motif.. 
+PF13227 Protein of unknown function (DUF4035)<br>Pfam-B_2076 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 67 and 93 amino acids in length.. 
+PF13228 Domain of unknown function (DUF4037)<br>Pfam-B_2110 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF13229 Right handed beta helix region<br>This region contains a parallel beta helix region that shares some similarity with Pectate lyases.. 
+PF13230 GATase_II;<br>Glutamine amidotransferases class-II. This family captures members that are not found in Pfam:PF00310.. 
+PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase<br>This family contains members that are not captured by Pfam:PF02366.. 
+PF13232 LYR-motif-like;<br>This is a family of proteins carrying the LYR motif of family Complex1_LYR, Pfam:PF05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.. 
+PF13233 Complex1_LYR-like<br>This is a family of proteins carrying the LYR motif of family Complex1_LYR, Pfam:PF05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.. 
+PF13234 rRNA-processing arch domain<br>Pfam-B_8473 (release 24). 
+PF13236 Clustered mitochondria<br>The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport [1,2] although the exact function of the domain is unknown  . In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane   suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast  . Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre  . It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure  .. 
+PF13237 4Fe-4S dicluster domain<br>This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF13238 AAA domain<br>
+PF13239 2TM domain<br>This short region contains two transmembrane alpha helices that are found associated with a wide range of other domains.  This domain may be involved in cell lysis or peptidoglycan turnover.. 
+PF13240 zinc-ribbon domain<br>This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. Pfam:PF12773.. 
+PF13241 Hydrolase_like;<br>Putative NAD(P)-binding. This domain is found in fungi, plants, archaea and bacteria.. 
+PF13242 HAD-hyrolase-like<br>
+PF13243 Prenyltransferase-like<br>
+PF13244 Domain of unknown function (DUF4040)<br>
+PF13245 Part of AAA domain<br>
+PF13246 Putative hydrolase of sodium-potassium ATPase alpha subunit<br>This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.. 
+PF13247 4Fe-4S dicluster domain<br>Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.. 
+PF13248 zinc-ribbon domain<br>This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. Pfam:PF12773.. 
+PF13249 Prenyltransferase-like<br>
+PF13250 Domain of unknown function (DUF4041)<br>Pfam-B_2162 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and viruses, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF10544.. 
+PF13251 Domain of unknown function (DUF4042)<br>Pfam-B_2172 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 180 amino acids in length.. 
+PF13252 Protein of unknown function (DUF4043)<br>Pfam-B_2174 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 369 and 424 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF13253 Protein of unknown function (DUF4044)<br>Pfam-B_2177 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 56 amino acids in length. There is a single completely conserved residue M that may be functionally important.. 
+PF13254 Domain of unknown function (DUF4045)<br>Pfam-B_2180 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.. 
+PF13255 Protein of unknown function (DUF4046)<br>Pfam-B_2182 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 64 and 331 amino acids in length.. 
+PF13256 Domain of unknown function (DUF4047)<br>Pfam-B_2183 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There are two conserved sequence motifs: TEA and FPKT.. 
+PF13257 Domain of unknown function (DUF4048)<br>Pfam-B_2186 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is typically between 228 and 257 amino acids in length.. 
+PF13258 Domain of unknown function (DUF4049)<br>Pfam-B_2191 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 310 and 324 amino acids in length.. 
+PF13259 Protein of unknown function (DUF4050)<br>Pfam-B_2193 (release 24.0). This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 173 amino acids in length. There are two conserved sequence motifs: IPL and FLVD.. 
+PF13260 Protein of unknown function (DUF4051)<br>Pfam-B_2194 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13261 Protein of unknown function (DUF4052)<br>Pfam-B_2197 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 220 amino acids in length.. 
+PF13262 Protein of unknown function (DUF4054)<br>Pfam-B_2204 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 120 and 152 amino acids in length.. 
+PF13263 PHP-associated<br>This is a subunit, probably the alpha, of bacterial and eukaryotic DNA polymerase III, associated with the PHP domain, Pfam:PF02811.. 
+PF13264 Domain of unknown function (DUF4055)<br>Pfam-B_2501 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 140 amino acids in length.. 
+PF13265 Protein of unknown function (DUF4056)<br>Pfam-B_2502 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 355 and 380 amino acids in length.. 
+PF13266 Protein of unknown function (DUF4057)<br>Pfam-B_2503 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 279 and 322 amino acids in length.. 
+PF13267 Protein of unknown function (DUF4058)<br>Pfam-B_2520 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 244 and 264 amino acids in length.. 
+PF13268 Protein of unknown function (DUF4059)<br>Pfam-B_2521 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DKT sequence motif.. 
+PF13269 Protein of unknown function (DUF4060)<br>Pfam-B_2524 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: VEVV and SYVAT.. 
+PF13270 Domain of unknown function (DUF4061)<br>Pfam-B_2526 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 90 amino acids in length. There is a conserved AFG sequence motif.. 
+PF13271 Domain of unknown function (DUF4062)<br>Pfam-B_2536 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.. 
+PF13272 Protein of unknown function (DUF4063)<br>Pfam-B_3026 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 95 and 123 amino acids in length. There is a conserved RRA sequence motif.. 
+PF13273 Protein of unknown function (DUF4064)<br>
+PF13274 Protein of unknown function (DUF4065)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and viruses. Proteins in this family are typically between 155 and 202 amino acids in length.. 
+PF13275 S4 domain<br>The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.. 
+PF13276 HTH-like domain<br>This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.. 
+PF13277 YmdB-like protein<br>This family of putative phosphoesterases contains the B. subtilis protein YmdB Swiss:O31775.. 
+PF13278 Putative amidotransferase<br>This domain contains similarities to other amidotransferase families such as Pfam:PF00117. Some members of the family lack the likely catalytic residues.. 
+PF13279 Thioesterase-like superfamily<br>This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily  .. 
+PF13280 WYL domain<br>This presumed domain is around 170 amino acids in length.\.    It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. There are a number of proteins that contain two tandem copies of this domain such as Swiss:Q47P13. This suggests that this domain may form a dimeric arrangement.. 
+PF13281 Domain of unknown function (DUF4071)<br>Pfam-B_2008 (release 24.0). This domain is found at the N-terminus of many serine-threonine kinase-like proteins.. 
+PF13282 Domain of unknown function (DUF4070)<br>Pfam-B_2005 (release 24.0). This is a bacterial domain often found at the C-terminus of Radical_SAM methylases.. 
+PF13283 Bacteriophage N adsorption protein A C-term<br>Pfam-B_2015 (release 24.0). The function of this domain is unknown but it is found at the C-terminus of bacteriophage N4 adsorption protein A, in association with an N-terminal region of TPR repeats.. 
+PF13284 Domain of unknown function (DUF4072)<br>Pfam-B_2021 (release 24.0). This short domain is normally found at the very N-terminus of Hyrdrolases Pfam:PF00702.. 
+PF13285 Domain of unknown function (DUF4073)<br>Pfam-B_2039 (release 24.0). This family is frequently found at the C-terminus of bacterial proteins carrying the family, Metallophos Pfam:PF00149.. 
+PF13286 Phosphohydrolase-associated domain<br>Pfam-B_2016 (release 24.0). This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.. 
+PF13287 Fn3 associated<br>
+PF13288 DXP reductoisomerase C-terminal domain<br>This is the C-terminal domain of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme. This domain forms a left handed super-helix.. 
+PF13289 SIR2-like domain<br>This family of proteins are related to the sirtuins.. 
+PF13290 Chitobiase/beta-hexosaminidase C-terminal domain<br>
+PF13291 ACT domain<br>ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.. 
+PF13292 1-deoxy-D-xylulose-5-phosphate synthase<br>This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6).. 
+PF13293 Domain of unknown function (DUF4074)<br>Pfam-B_2050 (release 24.0). This family is found at the C-terminal of Homeobox proteins in Metazoa.. 
+PF13294 Domain of unknown function (DUF4075)<br>Pfam-B_2028 (release 24.0). The members of this family are putative mature parasite-infected erythrocyte surface antigen protein from Bacillus spp.. 
+PF13295 Domain of unknown function (DUF4077)<br>Pfam-B_2043 (release 24.0). This is the N-terminal region of methyl-accepting chemotaxis proteins from Bacillus spp. The function is not known.. 
+PF13296 Putative type VI secretion system Rhs element Vgr<br>Pfam-B_2052 (release 24.0). This is a family of putative type VI secretion system Rhs element Vgr proteins from Proteobacteria.. 
+PF13297 DUF4076; Sde2_C;<br>Telomere stability C-terminal. Pfam-B_2053 (release 24.0). This short C-terminal domain is found in higher eukaryotes further downstream from the Sde2 family, Pfam:PF13019. It is found in all Sde2-related proteins except those from fission yeast, fly, and mosquito. Its exact function in telomere formation and maintenance has not yet been established.. 
+PF13298 DNA polymerase Ligase (LigD)<br>This is the N terminal region of ATP dependant DNA ligase.. 
+PF13299 Cleavage and polyadenylation factor 2 C-terminal<br>Pfam-B_2065 (release 24.0). This family lies at the C-terminus of many fungal and plant cleavage and polyadenylation specificity factor subunit 2 proteins. The exact function of the domain is not known, but is likely to function as a binding domain for the protein within the overall CPSF complex  .. 
+PF13300 Domain of unknown function (DUF4078)<br>Pfam-B_3305 (release 24.0). This family is found from fungi to humans, but its exact function is not known.. 
+PF13301 Protein of unknown function (DUF4079)<br>This is an uncharacterised family of proteins.. 
+PF13302 Acetyltransferase (GNAT) domain<br>This domain catalyses N-acetyltransferase reactions.. 
+PF13303 Phosphotransferase system, EIIC<br>The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.. 
+PF13304 AAA domain<br>
+PF13305 WHG domain<br>This presumed domain is around 80 amino acids in length.  It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule.  The domain is named WHG after three conserved residues near the C-terminus of the domain.. 
+PF13306 Leucine rich repeats (6 copies)<br>This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.. 
+PF13307 Helicase C-terminal domain<br>This domain is the second of two tandem AAA domains found in a wide variety of helicase enzymes.. 
+PF13308 YARHG domain<br>This presumed extracellular domain is about 70 amino acids in length. It is named YARHG after a conserved motif in the sequence. This domain is associated with peptidases and bacterial kinase proteins. Its molecular function is unknown.. 
+PF13309 HTH domain<br>This domain is a helix-turn-helix domain that is likely to act as a DNA-binding domain.. 
+PF13310 Virulence protein RhuM family<br>There are currently no experimental data for members of this group or their homologues. However, these proteins are implicated in virulence/pathogenicity because RhuM is encoded in the SPI-3 pathogenicity island in Salmonella typhimurium [1-2].. 
+PF13311 Protein of unknown function (DUF4080)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering  human gut metagenomic sequences  .. 
+PF13312 Domain of unknown function (DUF4081)<br>Pfam-B_2088 (release 24.0). This domain is often found N-terminal to the GNAT acetyltransferase domain, Pfam:PF00583 and FR47, Pfam:PF08445.. 
+PF13313 Domain of unknown function (DUF4082)<br>Pfam-B_2054 (release 24.0). This family appears to be a parallel beta-helix repeated region that sits between successive Cadherin domains, Pfam:PF00028.. 
+PF13314 Domain of unknown function (DUF4083)<br>Pfam-B_2061 (release 24.0). This is a family of very short, approximately 60 residue, proteins from Firmicutes, that are all putatively annotated as being MutT/Nudix. However, the characteristic Nudix motif of GX(5)EX(7)REUXEE is absent.. 
+PF13315 Protein of unknown function (DUF4085)<br>Pfam-B_2570 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 101 and 269 amino acids in length.. 
+PF13316 Protein of unknown function (DUF4087)<br>Pfam-B_3066 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 140 and 280 amino acids in length. There is a conserved RCGW sequence motif.. 
+PF13317 Protein of unknown function (DUF4088)<br>Pfam-B_3345 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 258 and 300 amino acids in length.. 
+PF13318 Protein of unknown function (DUF4089)<br>Pfam-B_3700 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF13319 Protein of unknown function (DUF4090)<br>Pfam-B_3702 (release 24.0). This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.. 
+PF13320 Domain of unknown function (DUF4091)<br>Pfam-B_3704 (release 24.0). This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF13321 Domain of unknown function (DUF4084)<br>Pfam-B_2026 (release 24.0). This family of Firmicute proteins is frequently associated with the EAL, GGDEF and PAS families, Pfam:PF00563, Pfam:PF00990, and Pfam:PF00989. The exact function is not known.. 
+PF13322 Domain of unknown function (DUF4092)<br>Pfam-B_2068 (release 24.0). This family is found in Proteobacteria. The function is not known.. 
+PF13323 N-terminal domain with HPIH motif<br>Pfam-B_2165 (release 24.0). This family is found in fungi on proteins carrying the PAS, Pfam:PF00989, domain. There is a well-conserved characteristic HPIH motif, but the function is not known.. 
+PF13324 Grap2 and cyclin-D-interacting<br>Pfam-B_2169 (release 24.0). GCIP, or Grap2 and cyclin-D-interacting protein, is found in eukaryotes, and in the protein Swiss:O95273, residues 149-190 constitute a helix-loop-helix domain, residues 190-240 an acidic region, and 240-261 a leucine zipper domain. GCIP interacts with full-length Grap2 protein and with the COOH-terminal unique and SH3 domains (designated QC domain) of Grap2. It is potentially involved in the regulation of cell differentiation and proliferation through Grap2 and cyclin D-mediated signalling pathways  . In mice, it is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumours. In vitro it acts as an inhibitory HLH protein, for example, blocking transcription of the HNF-4 promoter. In its function as a cyclin D1-binding protein it is able to reduce CDK4-mediated phosphorylation of the retinoblastoma protein and to inhibit E2F-mediated transcriptional activity  . GCIP has also been shown to have interact physically with Rad (Ras associated with diabetes), Rad being important in regulating cellular senescence  .. 
+PF13325 N-terminal region of micro-spherule protein<br>Pfam-B_2099 (release 24.0). This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1)  . In conjunction with DIPA the full-length protein acts as a transcription repressor  . The exact function of the region is not known.. 
+PF13326 Photosystem II Pbs27<br>This family of proteins contains Pbs27, a highly conserved component of photosystem II.  Pbs27 is comprised of four helices arranged in a right handed up-down-up-down fold, with a less ordered region located at the N-terminus  .. 
+PF13327 Type III secretion system subunit<br>Pfam-B_2123 (release 24.0). This is a family of bacterial putative type III secretion apparatus proteins associated with the locus of enterocyte effacement (LEE).. 
+PF13328 HD domain<br>HD domains are metal dependent phosphohydrolases.. 
+PF13329 Autophagy-related protein 2 CAD motif<br>Pfam-B_2170 (release 24.0). The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex. Atg2 binds Atg9. The precise function of this region, with its characteristic highly conserved CAD sequence motif, is not known.. 
+PF13330 Mucin-2 protein WxxW repeating region<br>Pfam-B_2205 (release 24.0). This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.. 
+PF13331 Domain of unknown function (DUF4093)<br>This domain lies at the C-terminus of primase proteins carrying the TOPRIM, Pfam:PF01751, domain. The exact function of the domain is not known.. 
+PF13332 Haemagluttinin repeat<br>
+PF13333 Integrase core domain<br>
+PF13334 Domain of unknown function (DUF4094)<br>Pfam-B_2504 (release 24.0). This domain is found in plant proteins that often carry a galactosyltransferase domain, Pfam:PF01762, at their C-terminus.. 
+PF13335 Magnesium chelatase, subunit ChlI<br>This is a family of putative bacterial magnesium chelatase subunit ChlI proteins. The domain lacks the P-loop region present at the N-terminal of Mg_chelatase, Pfam:PF01078.. 
+PF13336 Acetyl-CoA hydrolase/transferase C-terminal domain<br>This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA.. 
+PF13337 Putative ATP-dependent Lon protease<br>This is a family of proteins that are annotated as ATP-dependent Lon proteases.. 
+PF13338 Domain of unknown function (DUF4095)<br>
+PF13339 Apoptosis antagonizing transcription factor<br>Pfam-B_2199 (release 24.0). The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.. 
+PF13340 Putative transposase of IS4/5 family (DUF4096)<br>
+PF13341 RAG2 PHD domain<br>This domain is found at the C-terminus of the RAG2 protein. The structure of this domain has been shown bound to histone H3 trimethylated at lysine 4 (H3K4me3)  .. 
+PF13342 C-terminal repeat of topoisomerase<br>
+PF13343 Bacterial extracellular solute-binding protein<br>This family includes bacterial extracellular solute-binding proteins.. 
+PF13344 Haloacid dehalogenase-like hydrolase<br>This family is part of the HAD superfamily.. 
+PF13345 Domain of unknown function (DUF4098)<br>This domain is a C-terminal repeat found in many bacterial species.. 
+PF13346 ABC-2 family transporter protein<br>This family is related to the ABC-2 membrane transporter family Pfam:PF01061  .. 
+PF13347 MFS/sugar transport protein<br>This family is part of the major facilitator superfamily of membrane transport proteins.. 
+PF13348 Tyrosine phosphatase family C-terminal region<br>
+PF13349 Domain of unknown function (DUF4097)<br>
+PF13350 Tyrosine phosphatase family<br>This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.. 
+PF13351 Protein of unknown function (DUF4099)<br>JCSG - Joint Center for Structural Genomics. A family of uncharacterized proteins found by clustering human gut metagenomic sequences  . The C-terminal repeat region of this family is DUF4098, Pfam:PF13345.. 
+PF13352 Protein of unknown function (DUF4100)<br>This is a family of uncharacterised proteins found in Physcomitrella.. 
+PF13353 4Fe-4S single cluster domain<br>This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF13354 Beta-lactamase enzyme family<br>This family is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.. 
+PF13355 Protein of unknown function (DUF4101)<br>This is a family of uncharacterised proteins, and is sometimes found in combination with Pfam:PF00226.. 
+PF13356 Domain of unknown function (DUF4102)<br>This presumed domain is found at the N-terminus of a wide variety of phage integrase proteins.. 
+PF13358 DDE superfamily endonuclease<br>This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.. 
+PF13359 DDE_4;<br>DDE superfamily endonuclease. This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.. 
+PF13360 PQQ-like domain<br>This domain contains several repeats of the PQQ repeat.. 
+PF13361 UvrD-like helicase C-terminal domain<br>This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.. 
+PF13362 Toprim domain<br>The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation  .. 
+PF13363 Beta-galactosidase, domain 3<br>This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain has an Ig-like fold  .. 
+PF13364 Beta-galactosidase jelly roll domain<br>This domain is found in beta galactosidase enzymes.  It has a jelly roll fold  .. 
+PF13365 Trypsin-like peptidase domain<br>This family includes trypsin like peptidase domains.. 
+PF13366 PD-(D/E)XK nuclease superfamily<br>Members of this family belong to the PD-(D/E)XK nuclease superfamily. 
+PF13367 Protease prsW family<br>This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. Swiss:B7GHM8, PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Swiss:B7GHM8, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress  .. 
+PF13368 Topoisomerase C-terminal repeat<br>This domain is repeated up to five times to form the C-terminal region of bacterial topoisomerase immediately downstream of the zinc-finger motif.. 
+PF13369 Transglutaminase-like superfamily<br>
+PF13370 4Fe-4S single cluster domain<br>
+PF13371 Tetratricopeptide repeat<br>
+PF13372 DUF4104;<br>Coggill P, Eberhardt R. This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel  .. 
+PF13373 DUF2407 C-terminal domain<br>Pfam-B_17915 (release 21.0). This is a family of proteins found in fungi. The function is not known. There is a characteristic GFDRL sequence motif.. 
+PF13374 Tetratricopeptide repeat<br>
+PF13375 RnfC Barrel sandwich hybrid domain<br>This domain is part of the barrel sandwich hybrid superfamily. It is found at the N-terminus of the RnfC Electron transport complex protein. It appears to be most related to the N-terminal NQRA domain (Pfam:PF05896).. 
+PF13376 Bacteriocin-protection, YdeI or OmpD-Associated<br>This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice  . Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S)  . YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein  .. 
+PF13377 Periplasmic binding protein-like domain<br>Thi domain is found in a variety of transcriptional regulatory proteins. It is related to bacterial periplasmic binding proteins, although this domain is unlikely to be found in the periplasm. This domain likely acts to bind a small molecule ligand that the DNA-binding domain responds to.. 
+PF13378 Enolase C-terminal domain-like<br>This domain appears at the C-terminus of many of the proteins that carry the MR_MLE, Pfam:PF01188 and MR_MLE_N Pfam:PF02746 domains.  EC:4.2.1.40.. 
+PF13379 NMT1-like family<br>This family is closely related to the Pfam:PF09084 family.. 
+PF13380 CoA binding domain<br>This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.. 
+PF13382 Adenine deaminase C-terminal domain<br>This family represents a C-terminal region of the adenine deaminase enzyme.. 
+PF13383 Methyltransferase domain<br>This family appears to be a methyltransferase domain.. 
+PF13384 Homeodomain-like domain<br>
+PF13385 Concanavalin A-like lectin/glucanases superfamily<br>This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.. 
+PF13386 Cytochrome C biogenesis protein transmembrane region <br>Coggill P, Eberhardt R. 
+PF13387 Domain of unknown function (DUF4105)<br>This is a family of uncharacterised bacterial proteins. There is a highly conserved histidine residue and a well-conserved NCT motif.. 
+PF13388 Protein of unknown function (DUF4106)<br>This family of proteins are found in large numbers in the Trichomonas vaginalis proteome.  The function of this protein is unknown.. 
+PF13389 Protein of unknown function (DUF4107)<br>This family of putative proteins are found in Trichomonas vaginalis in large numbers.\.  The function of this protein is unknown.. 
+PF13390 Protein of unknown function (DUF4108)<br>This family of putative proteins are found in Trichomonas vaginalis in large numbers.\.  The function of this protein is unknown.. 
+PF13391 HNH endonuclease<br>Pfam-B_14 (Rel 25.0). 
+PF13392 HNH endonuclease<br>This is a zinc-binding loop of Fold group 7   as found in endo-deoxy-ribonucleases and HNH nucleases.. 
+PF13393 Histidyl-tRNA synthetase<br>This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.. 
+PF13394 4Fe-4S single cluster domain<br>
+PF13395 HNH endonuclease<br>This HNH nuclease domain is found in CRISPR-related proteins.. 
+PF13396 Phospholipase_D-nuclease N-terminal<br>This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, Pfam:PF00614. However, a large number of members are full-length within this family.. 
+PF13397 Domain of unknown function (DUF4109)<br>This is a family of bacterial proteins with several highly conserved characteristic sequence motifs, such as: APR, WxC and ERR. The function is not known.. 
+PF13398 Peptidase M50B-like<br>This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.. 
+PF13399 LytR cell envelope-related transcriptional attenuator<br>This family appears at the C-terminus of members of the LytR_cpsA_psr, Pfam:PF03816, family. 
+PF13400 Putative Flp pilus-assembly TadE/G-like<br>This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG [1,2].. 
+PF13401 AAA domain<br>
+PF13402 Peptidase M60-like family<br>This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity  .. 
+PF13403 Hint domain<br>This domain is found in inteins.. 
+PF13404 AsnC-type helix-turn-helix domain<br>
+PF13405 EF_hand_4;<br>
+PF13406 Transglycosylase SLT domain<br>This family is related to the SLT domain Pfam:PF01464.. 
+PF13407 Periplasmic binding protein domain<br>This domain is found in a variety of bacterial periplasmic binding proteins.. 
+PF13408 Recombinase zinc beta ribbon domain<br>This short bacterial protein contains a zinc ribbon domain that is likely to be DNA-binding. This domain is found in site specific recombinase proteins. This family appears most closely related to Pfam:PF04606.. 
+PF13409 Glutathione S-transferase, N-terminal domain<br>This family is closely related to Pfam:PF02798.. 
+PF13410 Glutathione S-transferase, C-terminal domain<br>This domain is closely related to Pfam:PF00043.. 
+PF13411 MerR HTH family regulatory protein<br>
+PF13412 Winged helix-turn-helix DNA-binding<br>
+PF13413 Helix-turn-helix domain<br>This domain is a helix-turn-helix domain that probably binds to DNA.. 
+PF13414 TPR repeat<br>
+PF13415 Galactose oxidase, central domain<br>
+PF13416 Bacterial extracellular solute-binding protein<br>This family includes bacterial extracellular solute-binding proteins.. 
+PF13417 Glutathione S-transferase, N-terminal domain<br>
+PF13418 Galactose oxidase, central domain<br>
+PF13419 Haloacid dehalogenase-like hydrolase<br>
+PF13420 Acetyltransferase (GNAT) domain<br>
+PF13421 SPFH domain-Band 7 family<br>
+PF13422 Domain of unknown function (DUF4110)<br>Pfam-B_8504 (release 24.0). This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.. 
+PF13423 Ubiquitin carboxyl-terminal hydrolase<br>
+PF13424 Tetratricopeptide repeat<br>
+PF13425 O-antigen ligase like membrane protein<br>
+PF13426 PAS domain<br>
+PF13427 Domain of unknown function (DUF4111)<br>Although the exact function of this domain is not known it frequently appears downstream of the family, Nucleotidyltransferase, Pfam:PF01909. It is also found in species associated with methicillin-resistant bacteria.. 
+PF13428 Tetratricopeptide repeat<br>
+PF13429 Tetratricopeptide repeat<br>
+PF13430 Domain of unknown function (DUF4112)<br>This family has several highly conserved GD sequence-motifs of unknown function. The family is found in bacteria, archaea and fungi.. 
+PF13431 Tetratricopeptide repeat<br>
+PF13432 Tetratricopeptide repeat<br>
+PF13433 Periplasmic binding protein domain<br>This domain is found in a variety of bacterial periplasmic binding proteins.. 
+PF13434 L_oxygenase;<br>L-lysine 6-monooxygenase (NADPH-requiring). This is family of Rossmann fold oxidoreductases that catalyses the NADPH-dependent hydroxylation of lysine at the N6 position, EC:1.14.13.59.. 
+PF13435 Cytochrome c554 and c-prime<br>This family is a tetra-haem cytochrome involved in the oxidation of ammonia. It is found in both phototrophic and denitrifying bacteria.. 
+PF13436 Glycine-zipper containing OmpA-like membrane domain<br>
+PF13437 HlyD family secretion protein<br>This is a family of largely bacterial haemolysin translocator HlyD proteins.. 
+PF13438 Domain of unknown function (DUF4113)<br>Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, Pfam:PF00817.. 
+PF13439 Glycosyltransferase Family 4<br>
+PF13440 Polysaccharide biosynthesis protein<br>
+PF13441 YMGG-like Gly-zipper<br>
+PF13442 Cytochrome C oxidase, cbb3-type, subunit III <br>
+PF13443 Cro/C1-type HTH DNA-binding domain<br>This is a helix-turn-helix domain that probably binds to DNA.. 
+PF13444 Acetyltransferase (GNAT) domain<br>This family contains proteins with N-acetyltransferase functions.. 
+PF13445 zf-RING_LisH;<br>RING-type zinc-finger. Pfam-B_49 (release 24.0). This zinc-finger is a typical RING-type of plant ubiquitin ligases  .. 
+PF13446 A repeated domain in UCH-protein<br>Pfam-B_2127 (release 24.0). This is a repeated domain found in de-ubiquitinating proteins. It's exact function is not known although it is likely to be involved in the binding of the Ubps in the complex with Rsp5 and Rup1.. 
+PF13447 Seven times multi-haem cytochrome CxxCH<br>This domain carries up to seven CxxCH repeated sequence motifs, characteristic of multi-haem cytochromes.. 
+PF13448 Domain of unknown function (DUF4114)<br>This is a repeated domain that is found towards the C-terminal of many different types of bacterial proteins. There are highly conserved glutamate and aspartate residues suggesting that this domain might carry enzymic activity.. 
+PF13449 Esterase-like activity of phytase<br>This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins. . 
+PF13450 NAD(P)-binding Rossmann-like domain<br>
+PF13451 Probable zinc-binding domain<br>This is a probable zinc-binding domain with two CxxC sequence motifs, found in various families of bacteria.. 
+PF13452 zf-MaoC;<br>N-terminal half of MaoC dehydratase. It is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.. 
+PF13453 Transcription factor zinc-finger<br>
+PF13454 FAD-NAD(P)-binding<br>
+PF13455 Meiotically up-regulated gene 113<br>Pfam-B_48720 (release 24.0). This is a family of fungal proteins found to be up-regulated in meiosis.. 
+PF13456 Reverse transcriptase-like<br>This domain is found in plants and appears to be part of a retrotransposon.. 
+PF13457 SH3-like domain<br>
+PF13458 Periplasmic binding protein<br>This family includes a diverse range of periplasmic binding proteins.. 
+PF13459 4Fe-4S single cluster domain<br>
+PF13460 NADH(P)-binding <br>
+PF13461 Cell-wall surface anchor repeat<br>
+PF13462 Thioredoxin<br>
+PF13463 Winged helix DNA-binding domain<br>
+PF13464 Domain of unknown function (DUF4115)<br>This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.. 
+PF13465 Zinc-finger double domain<br>
+PF13466 STAS domain<br>The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function  .. 
+PF13467 Ribbon-helix-helix domain<br>This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.. 
+PF13468 Glyoxalase-like domain<br>This domain is related to the Glyoxalase domain Pfam:PF00903.. 
+PF13469 Sulfotransferase family<br>
+PF13470 PIN domain<br>Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).. 
+PF13471 Transglutaminase-like superfamily<br>This family includes uncharacterised proteins that are related to the transglutaminase like domain Pfam:PF01841.. 
+PF13472 GDSL-like Lipase/Acylhydrolase family<br>This family of presumed lipases and related enzymes are similar to Pfam:PF00657.. 
+PF13473 Cupredoxin-like domain<br>The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.. 
+PF13474 SnoaL-like domain<br>This family contains a large number of proteins that share the SnoaL fold.. 
+PF13475 Domain of unknown function (DUF4116)<br>
+PF13476 AAA domain<br>
+PF13477 Glycosyl transferase 4-like<br>
+PF13478 XdhC Rossmann domain<br>This entry is the rossmann domain found in the Xanthine dehydrogenase accessory protein.. 
+PF13479 AAA domain<br>This AAA domain is found in a wide variety of presumed phage proteins.. 
+PF13480 Acetyltransferase (GNAT) domain<br>This family contains proteins with N-acetyltransferase functions.. 
+PF13481 AAA domain<br>This AAA domain is found in a wide variety of presumed DNA repair proteins.. 
+PF13482 RNase_H superfamily<br>
+PF13483 Beta-lactamase superfamily domain<br>This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.. 
+PF13484 4Fe-4S double cluster binding domain<br>
+PF13485 Peptidase MA superfamily<br>
+PF13486 Reductive dehalogenase subunit<br>This family is most frequently associated with a Fer4 iron-sulfur cluster towards the C-terminal region.. 
+PF13487 HD domain<br>HD domains are metal dependent phosphohydrolases.. 
+PF13488 Glycine zipper<br>
+PF13489 Methyltransferase domain<br>This family appears to be a methyltransferase domain.. 
+PF13490 Putative zinc-finger<br>This is a putative zinc-finger found in some anti-sigma factor proteins.. 
+PF13491 Domain of unknown function (DUF4117)<br>This family is frequently found on DNA-translocase FtsK proteins at the N-terminus. The function is not known but might well be enzymatic.. 
+PF13492 GAF domain<br>
+PF13493 Domain of unknown function (DUF4118)<br>This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.. 
+PF13494 Domain of unknown function, B. Theta Gene description (DUF4119)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_0594. Based on Bacteroides thetaiotaomicron gene BT_0594, a putative uncharacterised protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2]. 
+PF13495 Phage_integr_N2;<br>Phage integrase, N-terminal SAM-like domain. 
+PF13496 Domain of unknown function (DUF4120)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_2585. Based on Bacteroides thetaiotaomicron gene BT_2585, a putative uncharacterised protein.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].. 
+PF13497 Domain of unknown function (DUF4121)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_2588. Based on Bacteroides thetaiotaomicron gene BT_2588, a putative uncharacterised protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].. 
+PF13498 Domain of unknown function (DUF4122)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_2607. Based on Bacteroides thetaiotaomicron gene BT_2607, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].. 
+PF13499 EF_hand_5;<br>
+PF13500 AAA domain<br>This domain is found in a number of proteins involved in cofactor biosynthesis such as dethiobiotin synthase and cobyric acid synthase. This domain contains a P-loop motif.. 
+PF13501 Sulfur oxidation protein SoxY<br>This domain is found in the sulfur oxidation protein SoxY. It is closely related to the Desulfoferrodoxin family Pfam:PF01880. Dissimilatory oxidation of thiosulfate is carried out by the ubiquitous sulfur-oxidizing (Sox) multi-enzyme system. In this system, SoxY plays a key role, functioning as the sulfur substrate-binding protein that offers its sulfur substrate, which is covalently bound to a conserved C-terminal cysteine, to another oxidizing Sox enzyme  . The structure of this domain shows an Ig-like fold  .. 
+PF13502 AsmA-like C-terminal region<br>This family is similar to the C-terminal of the AsmA protein of E.  coli.. 
+PF13503 Domain of unknown function (DUF4123)<br>This presumed domain is functionally uncharacterised. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important.  This domain is sometimes associated with the FHA domain.. 
+PF13504 Leucine rich repeat<br>
+PF13505 Outer membrane protein beta-barrel domain<br>This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.. 
+PF13506 Glycosyl transferase family 21<br>This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.. 
+PF13507 CobB/CobQ-like glutamine amidotransferase domain<br>This family captures members that are not found in Pfam:PF00310, Pfam:PF07685 and Pfam:PF13230.. 
+PF13508 Acetyltransferase (GNAT) domain<br>This domain catalyses N-acetyltransferase reactions.. 
+PF13509 S1 domain<br>The S1 domain was originally identified as a repeat motif in the ribosomal S1 protein. It was later identified in a wide range of proteins. The S1 domain has an OB-fold structure. The S1 domain is involved in nucleic acid binding.. 
+PF13510 2Fe-2S iron-sulfur cluster binding domain<br>The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.. 
+PF13511 Domain of unknown function (DUF4124)<br>This presumed domain is found in a variety of bacterial proteins. It is found associated at the N-terminus associated with other domains such as the SLT domain and glutaredoxin domains in some proteins. The function of this domain is unknown, but it may have an Ig-like fold.. 
+PF13512 Tetratricopeptide repeat<br>
+PF13513 HEAT-like repeat<br>The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see Pfam:PF00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.. 
+PF13514 AAA domain<br>This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.. 
+PF13515 Fusaric acid resistance protein-like<br>
+PF13516 Leucine Rich repeat<br>
+PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella<br>This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).. 
+PF13518 Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.. 
+PF13519 von Willebrand factor type A domain<br>
+PF13520 Amino acid permease<br>
+PF13521 AAA domain<br>
+PF13522 Glutamine amidotransferase domain<br>This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes, such as asparagine synthetase and glutamine--fructose-6-phosphate transaminase.. 
+PF13523 Acetyltransferase (GNAT) domain<br>This domain catalyses N-acetyltransferase reactions.. 
+PF13524 Glycosyl transferases group 1<br>
+PF13525 Outer membrane lipoprotein<br>This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.. 
+PF13526 Protein of unknown function (DUF4125)<br>
+PF13527 Acetyltransferase (GNAT) domain<br>This domain catalyses N-acetyltransferase reactions.. 
+PF13528 Glycosyl transferase family 1<br>
+PF13529 Peptidase_C39 like family<br>
+PF13530 Sterol carrier protein domain<br>
+PF13531 Bacterial extracellular solute-binding protein<br>This family includes bacterial extracellular solute-binding proteins.. 
+PF13532 2OG-Fe(II) oxygenase superfamily<br>
+PF13533 Biotin-lipoyl like<br>
+PF13534 4Fe-4S dicluster domain<br>This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF13535 ATP-grasp domain<br>This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.. 
+PF13536 Multidrug resistance efflux transporter<br>This is a membrane protein family acting as a multidrug resistance efflux transporter.. 
+PF13537 Glutamine amidotransferase domain<br>This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes such as asparagine synthetase and glutamine-fructose-6-phosphate transaminase.. 
+PF13538 UvrD-like helicase C-terminal domain<br>This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.. 
+PF13539 D-alanyl-D-alanine carboxypeptidase<br>This family resembles VanY, Pfam:PF02557, which is part of the peptidase M15 family.. 
+PF13540 Regulator of chromosome condensation (RCC1) repeat<br>
+PF13541 Subunit ChlI of Mg-chelatase<br>
+PF13542 Helix-turn-helix domain of transposase family ISL3<br>
+PF13543 SAM like domain present in kinase suppressor RAS 1<br>
+PF13544 Type IV pilin N-term methylation site GFxxxE<br>This short sequence motif appears a the N-terminus of type IV prokaryotic filamentous adhesins or pilins. The N-terminal residue, which is methylated, is hydrophobic (generally a phenylalanine or a methionine), and this leader peptide is hydrophilic. The fifth residue of the mature sequence is a glutamate which seems to be required for the methylation step.. 
+PF13545 Crp-like helix-turn-helix domain<br>This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.. 
+PF13546 DDE superfamily endonuclease<br>This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.. 
+PF13547 GTA TIM-barrel-like domain<br>This domain is found in the gene transfer agent protein.  An unusual system of genetic exchange exists in the purple nonsulfur bacterium Rhodobacter capsulatus. DNA transmission is mediated by a small bacteriophage-like particle called the gene transfer agent (GTA) that transfers random 4.5-kb segments of the producing cell's genome to recipient cells, where allelic replacement occurs  . The genes involved in this process appear to be found widely in bacteria  . According to the SUPERFAMILY database this domain has a TIM barrel fold.. 
+PF13548 Domain of unknown function (DUF4126)<br>
+PF13549 ATP-grasp domain<br>This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.. 
+PF13550 Putative phage tail protein<br>This putative domain is found in the large gene transfer agent protein. These produce defective phage like particles. This domain is similar to other phage-tail protein families.. 
+PF13551 Winged helix-turn helix<br>This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.. 
+PF13552 Protein of unknown function (DUF4127)<br>This family of uncharacterised bacterial proteins are about 500 amino acids in length.. 
+PF13553 Function to find<br>Weichenberger CX, D'Osualdo A. Joint Center of Structural Genomics (JCSG). The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal)\.    . NLRP1 is a member of the Nod-like receptor (NLR) protein  superfamily and is involved in apoptosis and inflammation. To date,  it is the only NLR protein known to have a FIIND domain. The FIIND\. domain is also present in the CARD8 protein where, like in NLRP1,  it is followed by a C-terminal CARD domain. Both proteins are described\.     to form an "inflammasome", a macro-molecular complex able to process  caspase 1 and activate pro-IL1beta  . The FIIND domain is present\. in only a very small subset of the kingdom of life, comprising  primates, rodents (mouse, rat), carnivores (dog) and a few more,\.  such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein  failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR)  .  Upon discovery of CARD8 it was noted that the N-terminal region  shared significant sequence identity with an undescribed region in  NLRP1  . Before getting its final name, FIIND  , this domain  was termed NALP1-associated domain (NAD)  .. 
+PF13554 Bacteriophage related domain of unknown function<br>Wahab A, Serrano P, Geralt M, Wuthrich K. Bordetella bronchiseptica RB50 PDB:2L25. The three-dimesnional structure of NP_888769.1 (PDB:2L25) reveals\.      a tail terminator protein gpU fold, which suggests that    the protein could have a bacteriophage origin.. 
+PF13555 P-loop containing region of AAA domain<br>
+PF13556 PucR C-terminal helix-turn-helix domain<br>This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.. 
+PF13557 Putative MetA-pathway of phenol degradation<br>
+PF13558 Putative exonuclease SbcCD, C subunit<br>Possible exonuclease SbcCD, C subunit, on AAA proteins.. 
+PF13559 Domain of unknown function (DUF4129)<br>This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.. 
+PF13560 Helix-turn-helix domain<br>This domain is a helix-turn-helix domain that probably binds to DNA.. 
+PF13561 Enoyl-(Acyl carrier protein) reductase<br>
+PF13562 Sugar nucleotidyl transferase<br>This is a probable sugar nucleotidyl transferase family.. 
+PF13563 2'-5' RNA ligase superfamily<br>This family contains proteins related to Pfam:PF02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.. 
+PF13564 DoxX-like family<br>This family of uncharacterised proteins are related to DoxX Pfam:PF07681.. 
+PF13565 Homeodomain-like domain<br>
+PF13566 Domain of unknown function (DUF4130<br>
+PF13567 Domain of unknown function (DUF4131)<br>This domain is frequently found to the N-terminus of the Competence domain, Pfam:PF03772.. 
+PF13568 Outer membrane protein beta-barrel domain<br>This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.. 
+PF13569 Domain of unknown function (DUF4132)<br>This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.. 
+PF13570 YWTD;<br>Coggill P, Eberhardt R. 
+PF13571 Domain of unknown function (DUF4133)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_0094. Based on Bacteroides thetaiotaomicron gene BT_0094, a putative uncharacterized protein as seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or vs when in culture   .. 
+PF13572 Domain of unknown function (DUF4134)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_0095. Based on Bacteroides thetaiotaomicron gene BT_0095, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or vs when in culture   .. 
+PF13573 PbH1;<br>Coggill P, Eberhardt R. This repeat occurs several times in SprB, a cell surface protein involved in gliding motility in the bacterium Flavobacterium johnsoniae  . 
+PF13574 Metallo-peptidase family M12B Reprolysin-like<br>This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.. 
+PF13575 Domain of unknown function (DUF4135)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 380 amino acids in length. The family is found in association with Pfam:PF05147. This domain may be involved in synthesis of a lantibiotic compound.. 
+PF13576 Pentapeptide repeats (9 copies)<br>
+PF13577 SnoaL-like domain<br>This family contains a large number of proteins that share the SnoaL fold.. 
+PF13578 Methyltransferase domain<br>This family appears to be a methyltransferase domain.. 
+PF13579 Glycosyl transferase 4-like domain<br>
+PF13580 SIS domain<br>SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.. 
+PF13581 Histidine kinase-like ATPase domain<br>
+PF13582 Metallo-peptidase family M12B Reprolysin-like<br>This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.. 
+PF13583 Metallo-peptidase family M12B Reprolysin-like<br>This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.. 
+PF13584 Oxygen tolerance<br>This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.. 
+PF13585 C-terminal domain of CHU protein family<br>The function of this C-terminal domain is not known; there are several conserved tryptophan and asparagine residues.. 
+PF13586 Transposase DDE domain<br>Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.. 
+PF13587 N-terminal domain of DJ-1_PfpI family<br>This domain is found at the N-terminus of proteins from the DJ-1_PfpI family, Pfam:PF01965. The exact function is not known.. 
+PF13588 Type I restriction enzyme R protein N terminus (HSDR_N)<br>This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA  . Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA  .. 
+PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase<br>This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.. 
+PF13590 Domain of unknown function (DUF4136)<br>This domain is found in bacterial lipoproteins. The function is not known.. 
+PF13591 MerR HTH family regulatory protein<br>
+PF13592 Winged helix-turn helix<br>This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.. 
+PF13593 SBF-like CPA transporter family (DUF4137)<br>These family members are membrane transporter proteins of the CPA and AT superfamily.. 
+PF13594 Amidohydrolase<br>This family of enzymes are a part of a large metal dependent hydrolase superfamily  . The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source  . This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit  . Dihydroorotases (EC:3.5.2.3) are also included [4-5].. 
+PF13595 Domain of unknown function (DUF4138)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_4780. Based on Bacteroides thetaiotaomicron gene BT_4780, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].. 
+PF13596 PAS domain<br>
+PF13597 Anaerobic ribonucleoside-triphosphate reductase<br>
+PF13598 Domain of unknown function (DUF4139)<br>This family is usually found at the C-terminus of proteins.. 
+PF13599 Pentapeptide repeats (9 copies)<br>
+PF13600 N-terminal domain of unknown function (DUF4140)<br>This family is often found at the N-terminus of its member proteins, with DUF4139, Pfam:PF13598, at the C-terminus.. 
+PF13601 Winged helix DNA-binding domain<br>
+PF13602 Zinc-binding dehydrogenase<br>
+PF13603 Leucyl-tRNA synthetase, Domain 2<br>This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.. 
+PF13604 AAA domain<br>This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.. 
+PF13605 Domain of unknown function (DUF4141)<br>Ellrott K, Bakolitsa C. Bacteroides thetaiotaomicron: BT_4772. Based on Bacteroides thetaiotaomicron gene BT_4772, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].. 
+PF13606 Ankyrin repeat<br>Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.. 
+PF13607 Succinyl-CoA ligase like flavodoxin domain<br>This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.. 
+PF13608 Protein P3 of Potyviral polyprotein<br>This is the P3 protein section of the Potyviridae polyproteins. The function is not known except that the protein is essential to viral survival.. 
+PF13609 Gram-negative porin<br>
+PF13610 DDE domain<br>This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.. 
+PF13611 Serine peptidase of plant viral polyprotein, P1<br>Rawlings N, Coggill P. This family is the P1 protein of the Potyviridae polyproteins that is a serine peptidase at the N-terminus. The catalytic triad in Swiss:Q65730, the ssRNA positive-strand Brome streak mosaic rymovirus, is His-311, Asp-322 and Ser-355.. 
+PF13612 Transposase DDE domain<br>Transposase proteins are necessary for efficient DNA transposition.  This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction  .. 
+PF13613 DDE_4_2;<br>Helix-turn-helix of DDE superfamily endonuclease. This domain is the probable DNA-binding region of transposase enzymes, necessary for efficient DNA transposition. Most of the members derive from the IS superfamily IS5 and rather fewer from IS4.. 
+PF13614 AAA domain<br>This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.. 
+PF13615 Putative alanine racemase<br>This is a family of eukaryotic proteins which are putatively alanine racemase.. 
+PF13616 PPIC-type PPIASE domain<br>Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.. 
+PF13617 YnbE-like lipoprotein<br>This family includes lipoproteins similar to E. coli YnbE Swiss:P64448. Protein in this family are typically 60 amino acids in length and contain an N-terminal lipid attachment site, which has been included in the alignment to increase sensitivity. The specific function of these proteins is unknown.. 
+PF13618 Gluconate 2-dehydrogenase subunit 3<br>This family corresponds to subunit 3 of the Gluconate 2-dehydrogenase enzyme that catalyses the conversion of gluconate to 2-dehydro-D-gluconate   EC:1.1.99.3.. 
+PF13619 KTSC domain<br>This short domain is named after Lysine tRNA synthetase C-terminal domain. It is found at the C-terminus of some Lysyl tRNA synthetases as well as a single domain in bacterial proteins. The domain is about 60 amino acids in length and contains a reasonably conserved YXY motif in the centre of the sequence. The function of this domain is unknown but it could be an RNA binding domain.. 
+PF13620 Carboxypeptidase regulatory-like domain<br>
+PF13621 Cupin-like domain<br>This cupin like domain shares similarity to the JmjC domain.. 
+PF13622 Thioesterase-like superfamily<br>This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily  .. 
+PF13623 SurA N-terminal domain<br>This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.. 
+PF13624 SurA N-terminal domain<br>This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.. 
+PF13625 Helicase conserved C-terminal domain<br>This domain family is found in a wide variety of helicases and helicase-related proteins.. 
+PF13627 Prokaryotic lipoprotein-attachment site<br>In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached  .. 
+PF13628 Domain of unknown function (DUF4142)<br>This is a bacterial family of unknown function.. 
+PF13629 Pilus formation protein N terminal region<br>
+PF13630 SdpI/YhfL protein family<br>This family of proteins includes the SdpI and YhfL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein  .. 
+PF13631 Cytochrome b(N-terminal)/b6/petB<br>
+PF13632 Glycosyl transferase family group 2<br>Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis   .. 
+PF13633 Prokaryotic N-terminal methylation site<br>This short motif directs methylation of the conserved phenylalanine residue.  It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596. It is often described as TypeIV_pilin_GFxxxE.. 
+PF13634 Nucleoporin FG repeat region<br>This family includes a number of FG repeats that are found in nucleoporin proteins. This family includes the yeast nucleoporins Nup116, Nup100, Nup49, Nup57 and Nup 145.. 
+PF13635 Domain of unknown function (DUF4143)<br>This domain is almost always found C-terminal to an ATPase core family.. 
+PF13636 pre-rRNA processing and ribosome biogenesis<br>This family represents an evolutionarily conserved sequence motif of a set of proteins that are involved in pre-rRNA processing and ribosome biogenesis in S. cerevisiae.. 
+PF13637 Ankyrin repeats (many copies)<br>
+PF13638 PIN domain<br>Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).. 
+PF13639 Ring finger domain<br>
+PF13640 2OG-Fe(II) oxygenase superfamily<br>This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily  .. 
+PF13641 Glycosyltransferase like family 2<br>Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis   .. 
+PF13642 protein structure with unknown function<br>Serrano P, Geralt M, Mohanty B, Horst R, Wuthrich K. Shewanella amazonensis SB2B PDB:2L6O. A family based on the three-dimensional structure of YP_926445.1 (PDB:2L6O). 
+PF13643 Domain of unknown function (DUF4145)<br>This domain is found in a variety of restriction endonuclease enzymes. The exact function of this domain is uncertain.. 
+PF13644 DKNYY family<br>This family represents a group of proteins found enriched in fusobacteria. These proteins contain many repeats of a DKNXXYY motif. The repeats are spaced at about 35 amino acid residues intervals. These proteins are likely to be associated with the membrane. The specific function of these proteins is unknown.. 
+PF13645 L,D-transpeptidase catalytic domain<br>This family is related to Pfam:PF03734.. 
+PF13646 HEAT repeats<br>This family includes multiple HEAT repeats.. 
+PF13647 Glycosyl hydrolase family 80 of chitosanase A<br>Naumoff D, Coggill P. This is a small family of bacterial chitosanases.. 
+PF13648 Lipocalin-like domain<br>
+PF13649 Methyltransferase domain<br>This family appears to be a methyltransferase domain.. 
+PF13650 Aspartyl protease<br>This family consists of predicted aspartic proteases, typically from 180 to 230 amino acids in length, in MEROPS clan AA. This model describes the well-conserved 121-residue C-terminal region. The poorly conserved, variable length N-terminal region usually contains a predicted transmembrane helix.. 
+PF13651 Adenine-specific methyltransferase EcoRI<br>This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.. 
+PF13652 Domain of unknown function (DUF4146)<br>This is a family of short proteins which appear to be pre-cursors. All members are from Pseudomonas spp. The function is not known.. 
+PF13653 Glycerophosphoryl diester phosphodiesterase family<br>This family also includes glycerophosphoryl diester phosphodiesterases as well as agrocinopine synthase, the similarity to GDPD has been noted  . This family appears to have weak but not significant matches to mammalian phospholipase C Pfam:PF00388, which suggests that this family may adopt a TIM barrel fold.. 
+PF13654 AAA domain<br>This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.. 
+PF13655 N-terminal domain of reverse transcriptase<br>This domain is found at the N-terminus of bacterial reverse transcriptases.. 
+PF13656 RNA polymerase Rpb3/Rpb11 dimerisation domain<br>The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer.  The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000).  Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037).  Rpb11 is found as a continuous domain.  Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.. 
+PF13657 HipA N-terminal domain<br>This domain is found to the N-terminus of HipA-like proteins.  It is also found in isolation in some proteins.. 
+PF13659 Methyltransferase domain<br>This family contains methyltransferase domains.. 
+PF13660 Domain of unknown function (DUF4147)<br>This domain is frequently found at the N-terminus of proteins carrying the glycerate kinase-like domain MOFRL, Pfam:PF05161.. 
+PF13661 2OG-Fe(II) oxygenase superfamily<br>This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily  .. 
+PF13662 Toprim domain<br>The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation  .. 
+PF13663 Domain of unknown function (DUF4148)<br>
+PF13664 Domain of unknown function (DUF4149)<br>
+PF13665 Domain of unknown function (DUF4150)<br>
+PF13667 ThiC-associated domain <br>This domain is most frequently found at the N-terminus of the ThiC family of proteins, Pfam:PF01964. The function is not known.. 
+PF13668 Ferritin-like domain<br>This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.. 
+PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily<br>
+PF13670 Peptidase propeptide and YPEB domain<br>This region is likely to have a protease inhibitory function (personal obs:C Yeats).  The name is derived from Peptidase & Bacillus subtilis YPEB.. 
+PF13671 AAA domain<br>This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.. 
+PF13672 Protein phosphatase 2C<br>Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.. 
+PF13673 Acetyltransferase (GNAT) domain<br>This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.. 
+PF13675 Type IV pili methyl-accepting chemotaxis transducer N-term<br>This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP, signature towards the C-terminus.. 
+PF13676 TIR domain<br>This is a family of bacterial Toll-like receptors.. 
+PF13677 Membrane MotB of proton-channel complex MotA/MotB <br>This is the MotB member of the E.coli MotA/MotB proton-channel complex that forms the stator of the bacterial membrane flagellar motor. Key residues act as a plug to prevent premature proton flow. The plug is in the periplasm just C-terminal to the MotB TM, consisting of an amphipathic alpha helix flanked by Pro-52 and Pro-65, eg in Swiss:D3V2T1. In addition to the Pro residues, Ile-58, Tyr-61, and Phe 62 are also essential for plug function   .. 
+PF13678 NFkB-p65-degrading zinc protease<br>Rawlings N, Coggill P. This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65 thereby down-regulating the NF-kappaB signalling pathway  . NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.. 
+PF13679 Methyltrans_27;<br>Methyltransferase domain. This family appears to be a methyltransferase domain.. 
+PF13680 Protein of unknown function (DUF4152)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in archaea. Proteins in this family are approximately 230 amino acids in length. The structure of PF2046 from pyrococcus furiosus has been solved.  It shows an RNaseH like fold that conserves critical catalytic residues  . This suggests that these proteins may cleave nucleic acid.. 
+PF13681 Type IV pilus assembly protein PilX C-term<br>This family is likely to be the C-terminal region of type IV pilus assembly PilX or PilW proteins.. 
+PF13682 MCPsignal_assoc;<br>Chemoreceptor zinc-binding domain. The chemoreceptor zinc-binding domain (CZB) is found in bacterial signal transduction proteins - most frequently receptors involved in chemotaxis and motility, but also in c-di-GMP signalling and nitrate/nitrite-sensing. Originally discovered in the cytoplasmic chemoreceptor TlpD from Helicobacter pylori, it is often found C-terminal to the MCPsignal domain in cytoplasmic chemoreceptor proteins. The CZB domain contains a core sequence motif, Hxx[WFYL]x21-28Cx[LFMVI]Gx[WFLVI]x18-27HxxxH. The highly-conserved H-C-H-H residues of this motif are believed to coordinate zinc; mutating the latter two histidines of the motif to alanines abolishes Zn binding. This domain binds zinc with high affinity, with a Kd in the femtomolar range. Although the function of the CZB domain is not yet known, scientists have speculated that it may function as either an unknown signal input domain, based on its frequent association with signalling output domains, or as a domain that helps to stabilise protein tertiary or quaternary structure.. 
+PF13683 Integrase core domain<br>
+PF13684 Dihydroxyacetone kinase family<br>This is the kinase domain of the dihydroxyacetone kinase family.. 
+PF13685 Iron-containing alcohol dehydrogenase<br>
+PF13686 DsrE/DsrF/DrsH-like family<br>DsrE is a small soluble protein involved in intracellular sulfur  reduction  . The family also includes YrkE proteins.. 
+PF13687 Domain of unknown function (DUF4153)<br>Members of this family are annotated as putative inner membrane proteins.. 
+PF13688 Peptidase_M84;<br>Metallo-peptidase family M12. 
+PF13689 Domain of unknown function (DUF4154)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 207 amino acids in length. Many members are annotated as valyl-tRNA synthetase but this could not be confirmed.. 
+PF13690 Chemotaxis phosphatase CheX<br>CheX is very closely related to the CheC chemotaxis phosphatase, but it dimerises in a different way, via a continuous beta sheet between the subunits. CheC and CheX both dephosphorylate CheY, although CheC requires binding of CheD to achieve the activity of CheX. The ability of bacteria to modulate their swimming behaviour in the presence of external chemicals (nutrients and repellents) is one of the most rudimentary behavioural responses known, but the the individual components are very sensitively tuned  .. 
+PF13691 tRNase Z endonuclease<br>This is family of tRNase Z enzymes, that are closely related structurally to the Lactamase_B family members. tRNase Z is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Swiss:Q10155, is targeted to the nucleus and has an SV40 nuclear localisation signal at its N-terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, Swiss:P87168, is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues  .. 
+PF13692 Glycosyl transferases group 1<br>
+PF13693 Winged helix-turn-helix DNA-binding<br>
+PF13694 Sec63/Sec62 complex-interacting family<br>This is a family of closely related Hph proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER. Cells with mutant Hph1 and Hph2 proteins revealed phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterized. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium  .. 
+PF13695 Zinc-binding domain<br>This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.. 
+PF13696 Zinc knuckle<br>This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.. 
+PF13698 Domain of unknown function (DUF4156)<br>The function of this family is unknown but members are annotated as putative lipoprotein outer membrane proteins.. 
+PF13699 Domain of unknown function (DUF4157)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteristic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.. 
+PF13700 Domain of unknown function (DUF4158)<br>The exact function of this domain is not clear, but it frequently occurs as an N-terminal region of transposase 3 or IS3 family of insertion elements.. 
+PF13701 Transposase DDE domain group 1<br>Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.. 
+PF13702 Lysozyme-like<br>
+PF13703 PepSY-associated TM helix<br>This family represents a conserved TM helix found in bacteria and archaea.. 
+PF13704 Glycosyl transferase family 2<br>Members of this family of prokaryotic proteins include putative glucosyltransferases,. 
+PF13705 TRC8 N-terminal domain<br>This region is found at the N-terminus of the TRC8 protein Swiss:Q8WU17. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain  . It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG  .. 
+PF13706 PepSY-associated TM helix<br>This family represents a conserved TM helix found in bacteria and archaea.. 
+PF13707 RloB-like protein<br>This family includes the RloB protein that is found within a bacterial restriction modification operon.  This family includes the AbiLii protein that is found as part of a plasmid encoded phage abortive infection mechanism  . Deletion within abiLii abolished the phage resistance. The family includes some proteins annotated as CRISPR Csm2 proteins.. 
+PF13708 Methyltransferase domain<br>This family contains methyltransferase domains.. 
+PF13709 Domain of unknown function (DUF4159)<br>Members of this family are hypothetical proteins. TM prediction shows them to have two transmembrane regions, with a cytosolic region of about 25 amino acids between the two, and an N-terminus outside the membrane.. 
+PF13710 ACT domain<br>ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.. 
+PF13711 Domain of unknown function (DUF4160)<br>
+PF13712 Glycosyltransferase like family<br>Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.. 
+PF13713 Transcription factor BRX N-terminal domain<br>The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2].  BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway.  BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot  . This family features a short region, also alpha-helical, N-terminal to the repeated alpha-helices of family BRX, Pfam:PF08381  . BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action  .. 
+PF13714 Phosphoenolpyruvate phosphomutase<br>This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein Swiss:O86937 has been characterised as catalysing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr)  . This enzyme has a TIM barrel fold.. 
+PF13715 Cna_B_2;<br>Domain of unknown function (DUF4480). Coggill P, Eberhardt R. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF07715 and Pfam:PF00593. There is a single completely conserved residue G that may be functionally important.. 
+PF13716 Divergent CRAL/TRIO domain<br>This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues  .. 
+PF13717 zinc-ribbon domain<br>This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, Pfam:PF12773.. 
+PF13718 GNAT acetyltransferase 2<br>Coggill P, Eberhardt R. This domain has N-acetyltransferase activity [1,2]. It has a GCN5-related N-acetyltransferase (GNAT) fold  .. 
+PF13719 zinc-ribbon domain<br>This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, Pfam:PF12773.. 
+PF13720 Udp N-acetylglucosamine O-acyltransferase; Domain 2<br>This is domain 2, or the C-terminal domain, of Udp N-acetylglucosamine O-acyltransferase.  This enzyme is a zinc-dependent enzyme that catalyses the deacetylation of UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine to form UDP-3-O-(R-hydroxymyristoyl)glucosamine and acetate.. 
+PF13721 SecD export protein N-terminal TM region<br>This domain appears to be the fist transmembrane region of the SecD export protein. SecD is directly involved in protein secretion and important for the release of proteins that have been translocated across the cytoplasmic membrane.. 
+PF13722 C-terminal domain on CstA (DUF4161)<br>This domain is found at the C=terminal of most known CstA domain-containing proteins. The function is not known.. 
+PF13723 Beta-ketoacyl synthase, N-terminal domain<br>
+PF13724 DNA-binding domain<br>Coggill P, Eberhardt R. Pfam-B_65234 (release 24.0). This domain, often found on ovate proteins, binds to single-stranded and double-stranded DNA. Binding to DNA is not sequence-specific  .. 
+PF13725 Possible tRNA binding domain<br>Coggill P, Eberhardt R. This domain, found at the C-terminus of tRNA(Met) cytidine acetyltransferase, may be involved in tRNA-binding  .. 
+PF13726 Na+-H+ antiporter family<br>This family includes integral membrane proteins, some of which are NA+-H+ antiporters  .. 
+PF13727 CoA-binding domain<br>
+PF13728 F plasmid transfer operon protein<br>TraF protein undergoes proteolytic processing associated with export. The 19 amino acids at the amino terminus of the polypeptides appear to constitute a typical membrane leader peptide - not included in this family, while the remainder of the molecule is predicted to be primarily hydrophilic in character  . F plasmid TraF and TraH are required for F pilus assembly and F plasmid transfer, and they are both localised to the outer membrane in the presence of the complete F transfer region, especially TraV, the putative anchor  .. 
+PF13729 F plasmid transfer operon, TraF, protein<br>
+PF13730 Helix-turn-helix domain<br>
+PF13731 WxL domain surface cell wall-binding<br>The WxL motif appears in two or three copies in these bacterial proteins   and confers a cell surface localisation function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan  .. 
+PF13732 Domain of unknown function (DUF4162)<br>This domain is found at the C-terminus of bacterial ABC transporter proteins. The function is not known.. 
+PF13733 N-terminal region of glycosyl transferase group 7<br>This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.. 
+PF13734 Spi protease inhibitor<br>This family includes the inhibitor Spi and the pro-peptides of streptopain (SpeB).  SpeB is produced as a 43 kDa pre-pro-protein, which is secreted via the recently described Sec secretory pathway Exportal. There is tight coupling between this inhibitor and its associated protease: the gene for the inhibitor Spi is located directly downstream from the gene for the streptococcal cysteine protease SpeB, and the sequence of the inhibitor is very similar to that of the SpeB propeptide. This is an example of an inhibitor molecule that is a structural homologue of the cognate propeptide, and is genetically linked to the protease gene  .. 
+PF13735 tRNA nucleotidyltransferase domain 2 putative<br>
+PF13737 Transposase DDE domain<br>Transposase proteins are necessary for efficient DNA transposition.  This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.. 
+PF13738 Pyridine nucleotide-disulphide oxidoreductase<br>
+PF13739 Domain of unknown function (DUF4163)<br>The structure of this domain is and alpha-beta-two layer sandwich, identified from a Fervidobacterium nodosum Rt17-B1 like protein. The function is not known except that it is found in association with Heat-shock cognate 70kd protein 44kd ATPase, Pfam:PF11738.. 
+PF13740 ACT domain<br>ACT domains bind to amino acids and regulate associated enzyme domains.. 
+PF13741 Mitochondrial ribosomal protein S25<br>PfamB-B_2836 (release 25.0). This is the family of fungal 37S mitochondrial ribosomal S25 proteins.. 
+PF13742 OB-fold nucleic acid binding domain<br>This family contains OB-fold domains that bind to nucleic acids.. 
+PF13743 Thioredoxin<br>
+PF13744 Helix-turn-helix domain<br>Members of this family contains a DNA-binding helix-turn-helix domain.. 
+PF13745 HxxPF-repeated domain<br>This family is found in non-ribosomal peptide synthetase proteins, and can occur up to twelve times.. 
+PF13746 4Fe-4S dicluster domain<br>This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.. 
+PF13747 Domain of unknown function (DUF4164)<br>This is a family of short, approx 100 residue-long, bacterial proteins of unknown function. There is several conserved LE/LD sequence pairs.. 
+PF13748 ABC transporter transmembrane region<br>This family represents a unit of six transmembrane helices.. 
+PF13749 ATP-dependent DNA helicase recG C-terminal<br>This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.. 
+PF13750 Bacterial Ig-like domain (group 3)<br>This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.. 
+PF13751 Transposase DDE domain<br>Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.. 
+PF13752 Domain of unknown function (DUF4165)<br>
+PF13753 Putative flagellar system-associated repeat<br>This family appears to be a repeated unit that can occur up to 29 times in these outer membrane proteins. It is putatively associated with a novel flagellar system.. 
+PF13754 Bacterial Ig-like domain (group 3)<br>This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.. 
+PF13755 Sensor N-terminal transmembrane domain<br>Coggill P, Eberhardt R. This domain is found at the N-terminus of the sensor component of the two-component regulatory system. It includes a transmembrane region and part of the periplasmic region, which is likely to be involved in stimulus sensing  .. 
+PF13756 Stimulus-sensing domain<br>Coggill P, Eberhardt R. This domain is found in the periplasmic region of the sensor component of the two-component regulatory system. The periplasmic region is likely to be involved in stimulus sensing  .. 
+PF13757 Vault protein inter-alpha-trypsin domain<br>Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition  .  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.. 
+PF13758 Prefoldin subunit<br>This family includes prefoldin subunits that are not detected by Pfam:PF02996.. 
+PF13759 Putative 2OG-Fe(II) oxygenase<br>Coggill P, Eberhardt R. This family has structural similarity to the 2OG-Fe(II) oxygenase superfamily.. 
+PF13761 Domain of unknown function (DUF4166)<br>Coggill P, Eberhardt R. This domain is often found at the C-terminus of proteins containing Pfam:PF03435.. 
+PF13762 Mitochondrial splicing apparatus component<br>MNE1 is a novel component of the mitochondrial splicing apparatus responsible for the processing of a COX1 group I intron in yeast  . Yeast cells lacking MNE1 are deficient in intron splicing in the gene encoding the Cox1 subunit of cytochrome oxidase but do contain wild-type levels of the bc1 complex.. 
+PF13763 Domain of unknown function (DUF4167)<br>
+PF13764 E3 ubiquitin-protein ligase UBR4<br>This is a family of E£ ubiquitin ligase enzymes.. 
+PF13765 SPRY-associated domain<br>SPRY and PRY domains occur on PYRIN proteins. Their function is not known.. 
+PF13766 2-enoyl-CoA Hydratase C-terminal region<br>This is the C-terminal region of enoyl-CoA hydratase.. 
+PF13767 Domain of unknown function (DUF4168)<br>
+PF13768 von Willebrand factor type A domain<br>
+PF13769 Virulence factor<br>This domain is found in conserved virulence factors  . It is often found in association with Pfam:PF02985 and Pfam:PF08712.. 
+PF13770 Domain of unknown function (DUF4169)<br>
+PF13771 PHD-like zinc-binding domain<br>The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains.  The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.. 
+PF13772 AIG2-like family<br>This family is found in bacteria and metazoa.. 
+PF13773 Domain of unknown function (DUF4170)<br>
+PF13774 Regulated-SNARE-like domain<br>Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex  . Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterised by a conserved N-terminal domain with a profilin-like fold called a longin domain  .. 
+PF13775 Domain of unknown function (DUF4171)<br>This short family is frequently found at the N-terminus of Homeobox proteins.. 
+PF13776 Domain of unknown function (DUF4172)<br>The family is often found in association with Pfam:PF02661.. 
+PF13777 Domain of unknown function (DUF4173)<br>This domain of unknown function contains multiple predicted transmembrane domains.. 
+PF13778 Domain of unknown function (DUF4174)<br>This domain of unknown function is found in a putative tumour suppressor gene   and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion [2,3].. 
+PF13779 Domain of unknown function (DUF4175)<br>
+PF13780 Domain of unknown function (DUF4176)<br>
+PF13781 DoxX-like family<br>This family of uncharacterised proteins are related to DoxX Pfam:PF07681.. 
+PF13782 Stage V sporulation protein AB<br>This family of proteins is required for sporulation  .. 
+PF13783 Domain of unknown function (DUF4177)<br>
+PF13784 Fic/DOC family N-terminal<br>This domain is found at the N-terminus of the Fic/DOC family, Pfam:PF02661.. 
+PF13785 Domain of unknown function (DUF4178)<br>
+PF13786 Domain of unknown function (DUF4179)<br>
+PF13787 Protein of unknown function with HXXEE motif<br>This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.. 
+PF13788 Domain of unknown function (DUF4180)<br>
+PF13789 Domain of unknown function (DUF4181)<br>
+PF13790 Domain of unknown function (DUF4182)<br>This protein of unknown function contains a number of highly conserved cysteine residues, which may form disulphide bonds.. 
+PF13791 Sigma factor regulator C-terminal<br>This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain  .. 
+PF13792 Sulfate transporter N-terminal domain with GLY motif<br>This domain is found usually at the N-terminus of sulfate-transporter proteins. It carries a highly conserved GLY sequence motif, but the function of the domain is not known.. 
+PF13793 N-terminal domain of ribose phosphate pyrophosphokinase<br>This family is frequently found N-terminal to the Pribosyltran, Pfam:PF00156.. 
+PF13794 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like<br>
+PF13795 HupE / UreJ protein<br>These proteins contain many conserved histidines that may be involved in nickel binding.. 
+PF13796 Putative sensor<br>This family is often found at the N-terminus of proteins containing Pfam:PF07730 and Pfam:PF02518. The N-termini of proteins containing these two domains often function in stimulus sensing.. 
+PF13797 Post-transcriptional regulator<br>This family includes post-transcriptional regulators  .. 
+PF13798 Protein of unknown function with PCYCGC motif<br>This domain contains a PCYCGC motif and four other conserved cysteines. Its function is unknown.. 
+PF13799 Domain of unknown function (DUF4183)<br>This domain of unknown function contains a highly conserved ING motif.. 
+PF13800 Sigma factor regulator N-terminal<br>Coggill P, Eberhardt R. This domain is found near the N-terminus of a sigma factor regulator. The N-terminus is responsible for interaction with the sigma factor  .. 
+PF13801 Heavy-metal resistance<br>This is a metal-binding protein which is involved in resistance to heavy-metal ions [1,2]. The protein forms a four-helix hooked hairpin, consisting of two long alpha helices each flanked by a shorter alpha helix. It binds a metal ion in a type-2 like centre  . It contains two copies of an LTXXQ motif.. 
+PF13802 Galactose mutarotase-like<br>This family is found N-terminal to glycosyl-hydrolase domains, and appears to be similar to the galactose mutarotase superfamily.. 
+PF13803 Domain of unknown function (DUF4184)<br>This domain of unknown function contains several highly conserved histidines.. 
+PF13804 Retro-transcribing viruses envelope glycoprotein<br>This family comes from human endogenous retrovirus K envelope glycoproteins.. 
+PF13805 Eisosome component PIL1<br>In the budding yeast, S. cerevisiae, Pil1 and another cytoplasmic protein, Lsp1, together form large immobile assemblies at the plasma membrane that mark sites for endocytosis, called eisosomes.  Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalise nutrients in all eukaryotic cells.. 
+PF13806 Rieske-like [2Fe-2S] domain<br>
+PF13807 G-rich domain on putative tyrosine kinase<br>This domain is found between two families, Wzz, Pfam:PF02706 and CbiA Pfam:PF01656. There is a highly conserved GNVR sequence motif which characterises this domain. The function is not known.. 
+PF13808 DDE_Tnp_1-associated<br>This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, Pfam:PF01609 and its relatives.. 
+PF13809 Tubulin like<br>Many of the residues conserved in Tubulin, Pfam:PF00091, are also highly conserved in this family.. 
+PF13810 Domain of unknown function (DUF4185)<br>
+PF13811 Domain of unknown function (DUF4186)<br>
+PF13812 Pentatricopeptide repeat domain<br>This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. The exact function is not known.. 
+PF13813 Membrane bound O-acyl transferase family<br>
+PF13814 Replication-relaxation<br>This family includes proteins which are essential for plasmid replication   and plasmid DNA relaxation  .. 
+PF13815 Iguana/Dzip1-like DAZ-interacting protein N-terminal<br>The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.. 
+PF13816 Haem-containing dehydratase<br>This family includes aldoxime dehydratase, EC:4.99.1.5. This is a haem-containing enzyme, which catalyses the dehydration of aldoximes to their corresponding nitrile  . It also includes phenylacetaldoxime dehydratase, EC:4.99.1.7. This haem-containing enzyme catalyses the dehydration of Z-phenylacetaldoxime to phenylacetonitrile  . The enzyme forms an elliptic beta barrel, composed of eight beta-strands, flanked by alpha-helices  .. 
+PF13817 IS66 C-terminal element<br>
+PF13820 Putative nucleic acid-binding region<br>This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.. 
+PF13821 Domain of unknown function (DUF4187)<br>This family is found at the very C-terminus of proteins that carry a G-patch domain, Pfam:PF01585.  The domain is short and cysteine-rich.. 
+PF13822 Acyl-CoA carboxylase epsilon subunit<br>This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes  .. 
+PF13823 Alcohol dehydrogenase GroES-associated<br>This short domain is frequently found at the N-terminus of the alcohol dehydrogenase GroES-like domain, Pfam: PF08240.. 
+PF13824 Zinc-finger of mitochondrial splicing suppressor 51<br>Mss51 regulates the expression of cytochrome oxidase, so this domain is probably DNA-binding.. 
+PF13825 Paramyxovirus structural protein V/P N-terminus<br>This family consists of several Paramyxoviridae structural protein P and V sequences  . From a structural point of view, P is the best-characterised protein of the replicative complex. P is organised into two moieties that are functionally and structurally distinct: a C-terminal moiety (PCT) and an N-terminal moiety (PNT). PCT is the most conserved in sequence and contains all regions required for virus transcription, whereas PNT, which is poorly conserved, provides several additional functions required for replication  . P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional. The N, P, and L proteins of SeV and measles and mumps viruses are functionally equivalent. However, sequence identity between proteins from these viruses is limited, and the viruses have been placed in different genera (Respirovirus, Morbilivirus, and Rubulavirus, respectively).  SeV P protein (568 aa) is a modular protein with distinct functional domains. The N-terminal part of P (PNT) is a chaperone for N and prevents it from binding to non-viral RNA in the infected cell  .. 
+PF13826 Domain of unknown function (DUF4188)<br>
+PF13827 Domain of unknown function (DUF4189)<br>This domain of unknown function contains six well-conserved cysteine residues.. 
+PF13828 Domain of unknown function (DUF4190)<br>This integral membrane domain is functionally uncharacterised. One of the membrane helices contains two GXXG motifs that are usually associated with dimerisation.. 
+PF13829 Domain of unknown function (DUF4191)<br>
+PF13830 Domain of unknown function (DUF4192)<br>
+PF13831 PHD-finger<br>PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains  .  Several PHD fingers have been identified as binding modules of methylated histone H3  .. 
+PF13832 PHD-zinc-finger like domain<br>
+PF13833 EF_hand_6;<br>
+PF13834 Domain of unknown function (DUF4193)<br>This domain of unknown function contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.. 
+PF13835 Domain of unknown function (DUF4194)<br>
+PF13836 Domain of unknown function (DUF4195)<br>This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.. 
+PF13837 Myb/SANT-like DNA-binding domain<br>This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular Pfam:PF10545 seems most related.  This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.. 
+PF13838 Clathrin-H-link<br>This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain Pfam:PF09268.. 
+PF13839 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p<br>    N-terminal C rich potential sugar binding domain followed by the  PC-Esterase domain  .. 
+PF13840 ACT domain <br>The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements  . In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding  .. 
+PF13841 Beta defensin<br>The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation  .. 
+PF13842 DDE_Tnp_1-like zinc-ribbon<br>This zinc-ribbon domain is frequently found at the C-terminal of proteins derived from transposable elements.. 
+PF13843 Transposase IS4<br>
+PF13844 Glycosyl transferase family 41<br>This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues [1,2]. In addition to its function as an O-GlcNAc transferase, human OGT, Swiss:O15294, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1  .. 
+PF13845 Septum formation<br>This domain is found in a protein which is predicted to play a role in septum formation during cell division  .. 
+PF13846 Domain of unknown function (DUF4196)<br>Pfam-B_104093 (release 24.0). This is a short region of ccdc82_homologues that is conserved from Schizo. pombe up to humans.  The function is not known.. 
+PF13847 Methyltransferase domain<br>This family appears to be have methyltransferase activity.. 
+PF13848 Thioredoxin-like domain<br>
+PF13850 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)<br>This family is the N-terminal of ERGIC proteins  , ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, Pfam:PF07970.. 
+PF13851 Growth-arrest specific micro-tubule binding<br>This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localisation of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages  . Gas8 is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells.. 
+PF13852 Protein of unknown function (DUF4197)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 228 and 249 amino acids in length.. 
+PF13853 Olfactory receptor<br>The members of this family are transmembrane olfactory receptors.. 
+PF13854 Kelch motif<br>The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase   for which a structure has been solved  . The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure   as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.. 
+PF13855 Leucine rich repeat<br>Jackhmer:JCS-Target417241. 
+PF13856 ATP-binding sugar transporter from pro-phage<br>Members of this short family are putative ATP-binding sugar transporter-like protein.. 
+PF13857 Ankyrin repeats (many copies)<br>
+PF13858 Protein of unknown function (DUF4199)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 167 and 182 amino acids in length.. 
+PF13859 BNR repeat-like domain<br>This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.. 
+PF13860 FlgD Ig-like domain<br>This domains has an immunoglobulin like beta sandwich fold. It is found in the FlgD protein the flagellar hook capping protein. THe structure for this domain shows that it is inserted within a TUDOR like beta barrel domain  .. 
+PF13861 FlgD Tudor-like domain<br>This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it  .  However in some firmicute proteins this inserted domain is absent such as Q67K21.. 
+PF13862 p21-C-terminal region-binding protein<br>This family of p21-binding proteins is important as a modulator of p21 activity. The domain binds the C-terminal region of p21 in a ternary complex with CDK2, which results in inhibition of the kinase activity of CDK2.. 
+PF13863 Domain of unknown function (DUF4200)<br>This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.. 
+PF13864 Calmodulin-binding<br>
+PF13865 C-terminal duplication domain of Friend of PRMT1<br>Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation  .. 
+PF13866 SAP30 zinc-finger<br>SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two beta-strands and two alpha-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure revealed a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 zn-finger motif indicated a strong preference for nucleic acid substrates. The zinc-finger of SAP3 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex  .. 
+PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30<br>This C-terminal domain of the SAP30 proteins appears to be the binding region for Sin3.. 
+PF13868 Tumour suppressor, Mitostatin<br>Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement.  The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs)  .. 
+PF13869 Nucleotide hydrolase<br>Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, di-nucleoside and diphospho-inositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.. 
+PF13870 Domain of unknown function (DUF4201)<br>This is a family of coiled-coil proteins from eukaryotes. The function is not known.. 
+PF13871 Helicase_C-like<br>Strawberry notch proteins carry DExD/H-box groups and Helicase_C domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes  .. 
+PF13872 P-loop containing NTP hydrolase pore-1<br>
+PF13873 Myb/SANT-like DNA-binding domain<br>This presumed domain appears to be related to other Myb/SANT like DNA binding domains.  This family is greatly expanded in arthropods and higher eukaryotes.. 
+PF13874 Nucleoporin complex subunit 54<br>This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel.  The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them [1,2].. 
+PF13875 Domain of unknown function (DUF4202)<br>This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 187 and 205 amino acids in length. There are two conserved sequence motifs: LED and KMS. The function of these proteins is unknown, although many are incorrectly annotated as glutamyl tRNA synthetases.. 
+PF13876 Phage protein (N4 Gp49/phage Sf6 gene 66) family<br>This family of phage proteins is functionally uncharacterised. The family includes bacteriophage Sf6 gene 66 Swiss:Q716B1 as well as phage N4 GP49 protein Swiss:A0MZD7. Proteins in this family are typically between 87 and 154 amino acids in length. There is a conserved NGF sequence motif.. 
+PF13877 Potential Monad-binding region of RPAP3<br>This domain is found at the C-terminus of RNA-polymerase II-associated proteins.  These proteins bind to Monad and are involved in regulating apoptosis.\. They contain TPR-repeats towards the N_terminus.. 
+PF13878 zinc-finger of acetyl-transferase ESCO<br>
+PF13879 KIAA1430 homologue<br>This is a family of KIAA1430 homologues.  The function is not known.. 
+PF13880 ESCO1/2 acetyl-transferase<br>
+PF13881 Ubiquitin-2 like Rad60 SUMO-like<br>
+PF13882 Bravo-like intracellular region<br>This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY.  The function is not known.. 
+PF13883 Pyridoxamine 5'-phosphate oxidase<br>
+PF13884 Chaperone of endosialidase<br>This is the very C-terminal, chaperone, domain of the bacteriophage protein endosialidase. It releases itself, via the serine-lysine dyad at the N-terminus, from the remainder of the end-tail-spike. Cleavage occurs after the threonine which is the final residue of the End-tail-spike family, Pfam:PF12219. The endosialidase protein forms homotrimeric molecules in bacteriophages  . The catalytic dyad allows this portion of the molecule to be cleaved from the more N-terminal region such that the latter can fold and presumably bind to DNA.. 
+PF13885 Keratin, high sulfur B2 protein<br>
+PF13886 Domain of unknown function (DUF4203)<br>This is the N-terminal region of 7tm proteins.  The function is not known.. 
+PF13887 Myelin gene regulatory factor -C-terminal domain 1<br>This domain is found just downstream of Peptidase_S74, Pfam:PF13884.  The function is not known.. 
+PF13888 Myelin gene regulatory factor C-terminal domain 2<br>This domain is found further downstream of Peptidase_S74, Pfam:PF13884, and MRF_C1, Pfam:PF13887.  The function is not known.. 
+PF13889 DUF4204;<br>Chromosome segregation during meiosis. The proteins come from eukaryotes, plants and animals, and are necessary for chromosome segregation during meiosis.. 
+PF13890 Rab3 GTPase-activating protein catalytic subunit<br>This family is the probable catalytic subunit of the GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). It is likely to convert active Rab3-GTP to the inactive form Rab3-GDP.  Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. This complex interacts with DMXL2 [1,2,3].. 
+PF13891 Potential DNA-binding domain<br>This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.. 
+PF13892 DNA-binding domain<br>DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.. 
+PF13893 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)<br>JCSG:Target_421317_RF20609A. The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.. 
+PF13894 C2H2-type zinc finger<br>This family contains a number of divergent C2H2 type zinc fingers.. 
+PF13895 Immunoglobulin domain<br>This domain contains immunoglobulin-like domains.. 
+PF13896 Glycosyl-transferase for dystroglycan<br>This glycosyl-transferase brings about the glycosylation of the  alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix [1,2].. 
+PF13897 Golgi-dynamics membrane-trafficking<br>Sec14-like Golgi-trafficking  domain The GOLD domain is always found combined with lipid- or membrane-association domains  .. 
+PF13898 Domain of unknown function (DUF4205)<br>The proteins in this family are uncharacterised but often named FAM188B.. 
+PF13899 Thioredoxin-like<br>Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.. 
+PF13900 Putative binding domain<br>This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.. 
+PF13901 Domain of unknown function (DUF4206)<br>This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, Pfam:PF00169. 
+PF13902 R3H-associated N-terminal domain<br>This family is found at the N-terminus of R3H, Pfam:PF01424, domain-containing proteins.  The function is not known.. 
+PF13903 PMP-22/EMP/MP20/Claudin tight junction<br>Members of this family are claudins, that form tight junctions between cells.. 
+PF13904 Domain of unknown function (DUF4207)<br>This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.. 
+PF13905 Thioredoxin-like<br>Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.. 
+PF13906 C-terminus of AA_permease<br>This is the C-terminus of AA-permease enzymes that is not captured by the models Pfam:PF00324 and Pfam:PF13520.. 
+PF13907 Domain of unknown function (DUF4208)<br>This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins.  The exact function of the domain is undetermined.. 
+PF13908 Wnt and FGF inhibitory regulator<br>Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.. 
+PF13909 C2H2-type zinc-finger domain<br>
+PF13910 Domain of unknown function (DUF4209)<br>This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.. 
+PF13911 AhpC/TSA antioxidant enzyme<br>This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).. 
+PF13912 C2H2-type zinc finger<br>
+PF13913 zinc-finger of a C2HC-type<br>This family contains a number of divergent C2H2 type zinc fingers.. 
+PF13914 Phostensin PP1-binding and SH3-binding region<br>Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton  . Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends  .. 
+PF13915 Domain of unknown function (DUF4210)<br>This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.. 
+PF13916 PP1-regulatory protein, Phostensin N-terminal<br>Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton  .  Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends  .. 
+PF13917 Zinc knuckle<br>The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag  proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.. 
+PF13918 PLD-like domain<br>
+PF13919 Asx-hm;<br>Iyer LM, Aravind L, Godzik A, Coggill P. A conserved alpha helical domain with a characteristic LXXLL motif    . The LXXLL motif is detected in diverse transcription  factors, coactivators and corepressors and is implicated in mediating interactions between them  . The ASXH domain is found in animals, fungi and plants   and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade  of DUBs  .. 
+PF13920 Zinc finger, C3HC4 type (RING finger)<br>
+PF13921 Myb-like DNA-binding domain<br>This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family  .. 
+PF13922 PHD domain of transcriptional enhancer, Asx<br>This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.. 
+PF13923 Zinc finger, C3HC4 type (RING finger)<br>
+PF13924 Lipocalin-like domain<br>This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5 Swiss:B6SEG2 which is involved in biosynthesis of alnumycin  . The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein  . The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyse a final cyclisation reaction  .. 
+PF13925 con80 domain of Katanin<br>The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles  .  The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein  .. 
+PF13926 Domain of unknown function (DUF4211)<br>
+PF13927 Immunoglobulin domain<br>This family contains immunoglobulin-like domains.. 
+PF13928 Flocculin type 3 repeat<br>This repeat is found in the Flocculation protein FLO9 Swiss:P39712 close to its C-terminus.. 
+PF13929 mRNA stabilisation<br>This domain is an mRNA stabilisation factor  .. 
+PF13930 DNA/RNA non-specific endonuclease<br>
+PF13931 Kinesin-associated microtubule-binding<br>This domain binds to micotubules [1,2].. 
+PF13932 GidA associated domain 3<br>The GidA associated domain 3 is a motif that has been identified at the C-terminus of protein GidA. It consists of 4 helices, the last three being rather short and forming small bundle at the top end of the first longer one. It is here named helical domain 3 because in GidA it is preceded by two other C-terminal helical domain (based on crystal structures [1,2]). GidA is an tRNA modification enzyme found in bacteria and mitochondrial. Based on mutational analysis this domain has been suggested to be implicated in binding of the D-stem of tRNA   and to be responsible for the interaction with protein MnmE  . Structures of GidA in complex with either tRNA or MnmE are missing. Reported to bind to Pfam family MnmE, Pfam:PF12631.. 
+PF13933 Putative peptidase family<br>This family of putative peptidases are closely related to the M35 family Pfam:PF02102. In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these proteins is unknown. Members of this family are found to be fungal allergens.. 
+PF13934 Nuclear pore complex assembly<br>ELYS (embryonic large molecule derived from yolk sac) is conserved from fungi such Aspergillus nidulans and Schizosaccharomyces pombe to human  . It is important for the assembly of the nuclear pore complex  .. 
+PF13935 Ead/Ea22-like protein<br>This family contains phage proteins and bacterial proteins that are likely to represent integrated phage proteins. This family includes the Lambda phage Ea22 early protein as well as the Bacteriophage P22 Ead protein.. 
+PF13936 Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.. 
+PF13937 Domain of unknown function (DUF4212)<br>This family includes several putative integral membrane proteins.. 
+PF13938 Domain of unknown function (DUF4213)<br>This domain of unknown function has an enolase N-terminal domain-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the N-terminus of proteins containing DUF364, Pfam:PF04016.. 
+PF13939 Toxin TisB, type I toxin-antitoxin system<br>TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide. It is a hydrophobic membrane-spanning protein which inhibits cell growth  . Its expression is inhibited by the antisense RNA IstR-1, which acts as an antitoxin  .. 
+PF13940 Toxin Ldr, type I toxin-antitoxin system<br>This family includes the Ldr (long direct repeat) toxins. In Escherichia coli there are four Ldr toxins, LdrA, LdrB, LdrC and LdrD. These toxins inhibit cell growth, decrease cell viability and cause nucleoid condensation. LdrD expression is inhibited by the antisense RNA RdlD, which functions as an antitoxin  .. 
+PF13941 MutL protein<br>This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family  .. 
+PF13942 YfhG lipoprotein<br>This family includes the YfhG protein from E. coli Swiss:P0AD44. Members of this family have an N-terminal lipoprotein attachment site. The members of this family are functionally uncharacterized.. 
+PF13943 WPP domain<br>
+PF13944 Lipocalin-like domain<br>Jackhmmer:JCSG_Target393211_GS13544C. 
+PF13945 Salt tolerance down-regulator<br>NST1 is a family of proteins that seem to be involved, directly or indirectly, in the salt sensitivity of some cellular functions in yeast. It does this without affecting sodium accumulation. It negatively affects salt-tolerance through an interaction with the splicing factor Msl1p. This interaction stresses the importance of efficient RNA processing under salt stress conditions  .. 
+PF13946 Domain of unknown function (DUF4214)<br>Pfam-B_781 (release 24.0). This domain is found on a variety of different proteins including transferases, and allergen V5/Tpx-1 related proteins.. 
+PF13947 Wall-associated receptor kinase galacturonan-binding<br>This cysteine-rich GUB_WAK_bind domain is the extracellular part of this serine/threonine kinase that binds to the cell-wall pectins.. 
+PF13948 Domain of unknown function (DUF4215)<br>The function of this family is unknown.. 
+PF13949 ALIX V-shaped domain binding to HIV <br>The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, Pfam:PF03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.. 
+PF13950 UDP-glucose 4-epimerase C-term subunit<br>This domain is the very C-terminal subunit of UDP-glucose 4-epimerase.. 
+PF13952 Domain of unknown function (DUF4216)<br>This DUF is sometimes found at the C-terminal end of proteins carrying a Transposase_21 domain, Pfam:PF02992.. 
+PF13953 PapC C-terminal domain<br>The PapC C-terminal domain is a structural domain found at the C-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the C-terminal domain from PapC and its homologues. This domain has a beta-sandwich structure similar to the plug domain of PapC  .. 
+PF13954 PapC N-terminal domain<br>The PapC N-terminal domain is a structural domain found at the N-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the N-terminal domain from PapC and its homologues. This domain is involved in substrate binding  .. 
+PF13955 Toxin Fst, type I toxin-antitoxin system<br>Fst (faecalis plasmid stabilization toxin), also known as RNA I, is a toxic peptide. Its N-terminus forms a transmembrane alpha helix, its C terminus is disordered and is likely to be cytosolic. Its translation is inhibited by the antisense RNA, RNA II, which acts as an antitoxin [1,2].. 
+PF13956 Toxin Ibs, type I toxin-antitoxin system<br>The Ibs (induction brings stasis) proteins are a family of toxic peptides. Their expression is inhibited by the Sib antisense RNAs, which act as antitoxins  .. 
+PF13957 Toxin YafO, type II toxin-antitoxin system<br>YafO is a toxin which inhibits protein synthesis. It acts as a ribosome-dependent mRNA interferase. It forms part of a type II toxin-antitoxin system, where the YafN protein acts as an antitoxin [1,2]. This domain forms complexes with yafN antitoxins containing Pfam:PF02604.. 
+PF13958 Toxin ToxN, type III toxin-antitoxin system<br>ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI [1,2]. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex  .. 
+PF13959 Domain of unknown function (DUF4217)<br>This short domain is found at the C-terminus of many helicase proteins.. 
+PF13960 Domain of unknown function (DUF4218)<br>
+PF13961 Domain of unknown function (DUF4219)<br>This domain is very short and is found at the N-terminal of many Gag-pol polyprotein and related proteins. There is a highly conserved YxxWxxxM sequence motif.. 
+PF13962 Domain of unknown function<br>The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.. 
+PF13963 Transposase-associated domain<br>
+PF13964 Kelch motif<br>
+PF13965 dsRNA-gated channel SID-1<br>This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps  . They are required for systemic RNA interference [2,3].. 
+PF13966 zinc-binding in reverse transcriptase<br>This domain would appear to be a zinc-binding region of a putative reverse transcriptase.. 
+PF13967 Late exocytosis, associated with Golgi transport <br>This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localised to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface  .. 
+PF13968 Domain of unknown function (DUF4220)<br>This family is found in plants and is often associated with DUF294, Pfam:PF04578.. 
+PF13969 Pab87 octamerisation domain<br>This domain was first characterised as the C-terminal domain of Pab87 serine protease from Pyrococcus abyssi  . The domain is reported to play a crucial role in Pab87 octamerisation and active site compartmentalisation. Its up-and-down 8-stranded beta-barrel 3D structure is reminiscent of the one found in lipocalins.. 
+PF13970 Domain of unknown function (DUF4221)<br>JCSG_target-390208:A6KZ57. This family of bacterial proteins contains highly conserved asparagine and cysteine residues.\.  The function is not known.. 
+PF13971 MEI4-Rec24;<br>Meiosis-specific protein Mei4. Wood V, Coggill P, Eberhardt R. Pfam-B_78600 (release 24.0). This family of meiosis specific proteins is required for correct meiotic chromosome segregation and recombination  . It is required for meiotic DNA double-strand break (DSB) formation  .. 
+PF13972 Bacterial transcriptional repressor<br>This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.  The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription  .. 
+PF13973 Domain of unknown function (DUF4222)<br>This short protein is likely to be of phage origin. For example it is found in the Swiss:B6DZ51 Enterobacteria phage YYZ-2008. It is largely found in enteric bacteria. The molecular function of this protein is unknown.. 
+PF13974 YebO-like protein<br>This short protein is uncharacterized. It seems likely to be of phage origin as it is found in Swiss:Q9MCU2 and Swiss:Q9MCS4. The protein is also found in a variety of enteric bacteria.. 
+PF13975 gag-polyprotein putative aspartyl protease<br>This family of putative aspartyl proteases is found pre-dominantly in retroviral proteins.. 
+PF13976 GAG-pre-integrase domain<br>This domain is found associated with retroviral insertion elements and lies just upstream of the integrase region on the polyproteins.. 
+PF13977 Bacterial transcriptional repressor<br>This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity  . Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli  .. 
+PF13978 Protein of unknown function (DUF4223)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. These proteins are likely to be lipoproteins (attachment site currently included in alignment).. 
+PF13979 SopA-like catalytic domain<br>This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes. This domain contains the active site cysteine residue.. 
+PF13980 Uncharacterised protein family (UPF0370)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DWP sequence motif.. 
+PF13981 SopA-like central domain<br>This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes.. 
+PF13982 YbfN-like lipoprotein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. Members of this family are lipoproteins.. 
+PF13983 YsaB-like lipoprotein<br>This family of proteins is functionally uncharacterised. These proteins are related to E.coli YsaB Swiss:Q0TBP2. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. These proteins are lipoproteins.. 
+PF13984 MsyB protein<br>The MsyB protein has been found to be able to restore protein export defects caused by a temperature-sensitive secY or secA mutation  . However, its exact molecular function is still unknown, but it may play a role in protein export. Proteins in this family are approximately 120 amino acids in length. This family of proteins is found in bacteria.. 
+PF13985 YbgS-like protein<br>This family of proteins is functionally uncharacterised. The family includes the YbgS protein from E. coli Swiss:P0AAV6. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. Some members of this family are annotated as homeobox protein, but this annotation cannot be verified.. 
+PF13986 Domain of unknown function (DUF4224)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. The protein is likely to be of phage origin and is found as protein Gp02 Swiss:C8CLF5 in the Xylella phage Xfas53  .. 
+PF13987 YedD-like protein<br>This family of proteins related to the YedD protein is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. These proteins are lipoproteins.. 
+PF13988 Protein of unknown function (DUF4225)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 182 and 282 amino acids in length.. 
+PF13989 YejG-like protein<br>The YejG protein family is a group of functionally uncharacterised proteins related to Swiss:P0AD21. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.. 
+PF13990 YjcZ-like protein<br>This family of proteins is functionally uncharacterised. The family includes the YjcZ protein from E. coli Swiss:P39267. This family of proteins is found in enteric bacteria. Proteins in this family are approximately 300 amino acids in length. There are two conserved sequence motifs: FGD and MPR.. 
+PF13991 BssS protein family<br>The BssS protein family is a group of proteins that are involved in regulation of biofilm formation  .  Proteins in this family are approximately 80 amino acids in length.. 
+PF13992 YecR-like lipoprotein<br>The YecR-like family of lipoproteins includes the YecR protein from E. coli Swiss:P76308. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 110 amino acids in length.. 
+PF13993 YccJ-like protein<br>The YccJ-like family of proteins includes the E. coli YccJ protein   Swiss:P0AB14 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF13994 PgaD-like protein<br>This family includes the PgaD protein from E. coli Swiss:P69432. The homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (beta-1,6-GlcNAc; PGA) serves as an adhesin for the maintenance of biofilm structural stability in eubacteria. The pgaABCD operon is required for its synthesis and export. It has been shown that PgaD is essential for this process  .. 
+PF13995 YebF-like protein<br>The YebF-like protein family appears to be a group of colicin immunity proteins. As well as YebF the family includes cmi, the colicin M immunity protein  . This domain family is found in bacteria, and is approximately 80 amino acids in length. The alignment contains two conserved cysteine residues that form a disulphide bond in the solved structure  .. 
+PF13996 YobH-like protein<br>The YobH-like protein family includes the YobH protein from E. coli Swiss:Q2MB16 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: GYG and GLGL.. 
+PF13997 YqjK-like protein<br>The YqjK-like protein family includes the E. coli YqjK protein Swiss:Q47710 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue R that may be functionally important.. 
+PF13998 MgrB protein<br>The MgrB protein is a short lipoprotein.  The mgrB gene has a mg2+ responsive promoter  . Deletion of mgrB results in a potent increase in PhoP-regulated transcription  . The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.. 
+PF13999 MarB protein<br>The MarB protein is found in the multiple antibiotic resistance (mar) locus in Escherichia coli. The MarB protein is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved GSDKSD sequence motif.. 
+PF14000 DNA packaging protein FI<br>This family includes the lambda phage DNA-packaging protein FI. Proteins in this family are typically between 124 and 140 amino acids in length.  There is a conserved EEE sequence motif.. 
+PF14001 YdfZ protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved YDRNRN sequence motif. The E. coli protein has been shown to bind selenium  .. 
+PF14002 YniB-like protein<br>The YniB-like protein family includes the E. coli YniB protein Swiss:P76208 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 180 amino acids in length. This family of proteins are integral membrane proteins.. 
+PF14003 YlbE-like protein<br>The YlbE-like protein family includes the B. subtilis protein YlbE Swiss:O34958 which is functionally uncharacterised. This family of cytosolic proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a conserved WYR sequence motif.. 
+PF14004 Protein of unknown function (DUF4227)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF14005 YpjP-like protein<br>The YpjP-like protein family includes the B. subtilis YpjP protein Swiss:P54172 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.. 
+PF14006 YqzL-like protein<br>The YqzL-like protein family includes the B. subtilis YqzL protein Swiss:C0H452 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.. 
+PF14007 YtpI-like protein<br>The YtpI-like protein family includes the B. subtilis YtpI protein Swiss:O34922 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 101 amino acids in length.. 
+PF14008 Iron/zinc purple acid phosphatase-like protein C<br>This domain is found at the C-terminus of Purple acid phosphatase proteins.. 
+PF14009 Domain of unknown function (DUF4228)<br>This domain is found in plants. The function is not known.. 
+PF14010 Phosphoenolpyruvate carboxylase<br>This family of phosphoenolpyruvate carboxylases is based on seqeunces not picked up by the model for PEPcase, PF00311. Most of the family members are from Archaea.. 
+PF14011 EspG family<br>This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis.  These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread  . Proteins in this family are typically between 254 and 295 amino acids in length.. 
+PF14012 Protein of unknown function (DUF4229)<br>This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.. 
+PF14013 MT0933-like antitoxin protein<br>This family of proteins contains the MT0933 protein Swiss:O05901 which has been identified as an antitoxin to /protein MT0934  . This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.. 
+PF14014 Protein of unknown function (DUF4230)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 203 and 228 amino acids in length.. 
+PF14015 Protein of unknown function (DUF4231)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 148 and 288 amino acids in length.. 
+PF14016 Protein of unknown function (DUF4232)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.. 
+PF14017 Protein of unknown function (DUF4233)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.. 
+PF14018 Domain of unknown function (DUF4234)<br>This presumed integral membrane protein domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length.. 
+PF14019 Protein of unknown function (DUF4235)<br>This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 88 and 119 amino acids in length.. 
+PF14020 Protein of unknown function (DUF4236)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 402 amino acids in length.. 
+PF14021 Protein of unknown function (DUF4237)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 123 and 781 amino acids in length.. 
+PF14022 Protein of unknown function (DUF4238)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 274 and 374 amino acids in length.. 
+PF14023 Protein of unknown function (DUF4239)<br>Jackhmmer:Catenulispora acidiphila . This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 254 and 270 amino acids in length.. 
+PF14024 Protein of unknown function (DUF4240)<br>This presumed domain is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain Pfam:PF05406.. 
+PF14025 Protein of unknown function (DUF4241)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 205 and 315 amino acids in length. There is a conserved GDG sequence motif at the C-terminus.. 
+PF14026 Protein of unknown function (DUF4242)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.. 
+PF14027 Protein of unknown function (DUF4243)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 348 and 477 amino acids in length.. 
+PF14028 SpaB C-terminal domain<br>This presumed domain is found at the C-terminus of the SpaB protein Swiss:P39774. SpaB is involved in the synthesis of the lantibiotic subtilin.\.   This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 317 and 1029 amino acids in length. The family is often found in association with Pfam:PF04737, Pfam:PF04738. This domain is found in isolation in some proteins. This domain is also found in EpiB involved in epidermin biosynthesis.. 
+PF14029 Protein of unknown function (DUF4244)<br>Jackhmmer:Catenulispora acidiphila . This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.. 
+PF14030 Protein of unknown function (DUF4245)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.. 
+PF14031 Putative serine dehydratase domain<br>This domain is found at the C-terminus of yeast D-serine dehydratase  . Structures have been solved for two bacterial members of this family. The yeast protein has been shown to be a zinc dependant enzyme.. 
+PF14032 PknH-like extracellular domain<br>This domain is functionally uncharacterised. It is found as the periplasmic domain of the bacterial protein kinase PknH  . The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond.  A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.. 
+PF14033 Protein of unknown function (DUF4246)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 392 and 644 amino acids in length.. 
+PF14034 Sporulation protein YtrH<br>This family of proteins is involved in sporulation. It may contribute to the formation and stability of the thick peptidoglycan layer between the two membranes of the spore, known as the cortex  . In Bacillus subtilis its expression is regulated by sigma-E  .. 
+PF14035 YlzJ-like protein<br>The YlzJ-like protein family includes the B. subtilis YlzJ protein Swiss:C0H413, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 72 amino acids in length. There are two completely conserved residues (L and G) that may be functionally important.. 
+PF14036 YlaH-like protein<br>The YlaH-like protein family includes the B. subtilis YlaH protein Swiss:O07632, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a conserved LGFA sequence motif.. 
+PF14037 YoqO-like protein<br>The YoqO-like protein family includes the B. subtilis YoqO protein Swiss:O31923, which is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 120 amino acids in length. There are two completely conserved residues (I and Y) that may be functionally important.. 
+PF14038 YqzE-like protein<br>The YqzE-like protein family includes the B. subtilis YqzE protein Swiss:O32020, which is functionally uncharacterised. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK  .  This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.. 
+PF14039 YusW-like protein<br>The YusW-like protein family includes the B. subtilis YusW protein Swiss:O32189, which is functionally uncharacterised. This family of proteins is found in bacteria, and is approximately 90 amino acids in length.. 
+PF14040 Deoxyribonuclease NucA/NucB<br>Members of this family act as deoxyribonucleases  .. 
+PF14041 LppP/LprE lipoprotein<br>The family includes putative lipoproteins LppP and LprE from species of Mycobacterium. LppP is required for optimal growth of M. tuberculosis  .. 
+PF14042 Domain of unknown function (DUF4247)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 143 and 271 amino acids in length.. 
+PF14043 WVELL protein<br>This family includes the B. subtilis YfjH protein Swiss:O31578, which is functionally uncharacterised.  This is not a homologue of E. coli YfjH, a synonym for IscX, which belongs to Pfam:PF04384.  This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length and contain a highly conserved WVELL motif.. 
+PF14044 NETI protein<br>This family includes the B. subtilis YebG protein Swiss:O34700, which is functionally uncharacterised. This is not a homologue of E. coli YebG, which belongs to Pfam:PF07130. This family of proteins is found in bacteria.  Proteins in this family are typically between 42 and 66 amino acids in length and contain a conserved NETI motif.. 
+PF14045 YIEGIA protein<br>This family includes the B. subtilis YphB protein Swiss:P50742, which is functionally uncharacterised. Its expression is regulated by the sporulation transcription factor sigma-F, however it is not essential for sporulation or germination  . This is not a homologue of E. coli YphB, which belongs to Pfam:PF01263.\.    This family of proteins is found in bacteria. Proteins in this family are typically between 276 and 300 amino acids in length and contain a conserved YIEGIA motif.. 
+PF14046 Nuclear receptor repeat<br>Joint Center of Structural Genomics (JCSG). This is a repeat domain involved in dimerisation of nuclear receptors proteins and in transcriptional regulation in general. It contains a  Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan  nuclear receptor Dax-1, which represses the constitutively expressed  protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1  . The domain is subject to structure\. determination by the Joint Center of Structural Genomics.. 
+PF14047 Dppa2/4 conserved region<br>Joint Center of Structural Genomics (JCSG). This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis  . Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.. 
+PF14048 C-terminal domain of methyl-CpG binding protein 2 and 3<br>Joint Center of Structural Genomics (JCSG). CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2   and MBD3  , the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex  , an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics.. 
+PF14049 Dppa2/4 conserved region in higher vertebrates<br>Joint Center of Structural Genomics (JCSG). Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homologue in Xenopus laevis  , reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.. 
+PF14050 N-terminal conserved domain of Nudc.<br>Joint Center of Structural Genomics (JCSG). The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics.  NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger  .. 
+PF14051 N-terminal domain of DPF2/REQ.<br>Joint Center of Structural Genomics (JCSG). This putative domain has been detected on the human DPF2 protein and was subsequently targeted for structure determination by the Joint Center for Structural Genomics (JCSG). Possibly, the C-terminus extends by 30 amino acids and forms a separate domain. DPF2 interacts with estrogen related receptor alpha (Err-alpha), an orphan receptor which acts as a regulator in energy metabolism  .  It was also identified as an adaptor molecule that links nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa-B) dimer RelB/p52 and switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling factor  .. 
+PF14052 Capsule assembly protein Wzi<br>Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation  . This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure  .. 
+PF14053 Domain of unknown function (DUF4248)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 86 amino acids in length.. 
+PF14054 Domain of unknown function (DUF4249)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 279 and 365 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.. 
+PF14055 NVEALA protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 92 amino acids in length. There is a conserved NVEALA sequence motif.. 
+PF14056 Domain of unknown function (DUF4250)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are two completely conserved residues (N and R) that may be functionally important.. 
+PF14057 GGGtGRT protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 330 amino acids in length and contain many highly conserved residues including a GGGtGRT motif.. 
+PF14058 PcfK-like protein<br>The PcfK-like protein family includes the Enterococcus faecalis PcfK protein Swiss:Q82YK9 which is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 137 and 257 amino acids in length. There are two completely conserved residues (D and L) that may be functionally important.. 
+PF14059 Domain of unknown function (DUF4251)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 196 amino acids in length.. 
+PF14060 Domain of unknown function (DUF4252)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 182 amino acids in length.. 
+PF14061 Polycomb-like MTF2 factor 2<br>Joint Center of Structural Genomics (JCSG). Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression  . The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.. 
+PF14062 Domain of unknown function (DUF4253)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.. 
+PF14063 Protein of unknown function (DUF4254)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 195 and 207 amino acids in length.. 
+PF14064 HmuY protein<br>HmuY is a novel heme-binding protein   that recruits heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR.\.    This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 278 amino acids in length.. 
+PF14065 Protein of unknown function (DUF4255)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 320 amino acids in length.. 
+PF14066 Protein of unknown function (DUF4256)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.. 
+PF14067 LssY C-terminus<br>This domain is found at the C-terminus of Legionella LssY proteins, which may be a part of the type I secretion system  . This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 182 and 195 amino acids in length. It is often found in association with Pfam:PF09335 and PF01569. There are two completely conserved residues (P and W) that may be functionally important.. 
+PF14068 Putative membrane protein<br>This family of bacterial proteins is functionally uncharacterised.  Proteins in this family are approximately 100 amino acids in length. There is a conserved FGIGF sequence motif, and many members are putative membrane proteins.. 
+PF14069 Stage VI sporulation protein F<br>The sporulation-specific SpoVIF (YjcC) protein of Bacillus subtilis is essential for the development of heat-resistant spores. Its expression is governed by SigK [1,2].. 
+PF14070 Putative motility protein<br>This family of proteins is regulated in B. subtilis by SigD, and is likely to be involved in motility or flagellin production, Proteins in this family are approximately 60 amino acids in length, and contain two highly conserved asparagine residues.. 
+PF14071 Putative coat protein<br>This is a family of putative bacterial coat proteins. Proteins in this family are approximately 140 amino acids in length.. 
+PF14072 DNA-sulfur modification-associated<br>This is family of bacterial proteins likely to be necessary for binding to DNA and recognising the modification sites.  Members are found in bacteria, archaea and on viral plasmids, and are typically between 354 and 474 amino acids in length. There is a conserved DGQHR sequence motif.. 
+PF14073 Centrosome localisation domain of Cep57<br>The CLD or centrosome localisation domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component.  This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, Pfam:PF06657, is the microtubule-binding region of Cep57.. 
+PF14074 Protein of unknown function (DUF4257)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF14075 Ubinuclein conserved middle domain<br>Joint Center of Structural Genomics (JCSG). Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone  complex involved in the formation of a certain type of facultative  heterochromatin, called senescence-associated heterochromatin foci  (SAHF)    . The domain described here is conserved in many  eukaryotes such as human, rat, drosophila, and zebra-fish and has been  targeted for protein structure determination by the Joint Center  for Structural Genomics.. 
+PF14076 Domain of unknown function (DUF4258)<br>Jackhmmer:Chitinophaga pinensis . This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 95 and 124 amino acids in length.. 
+PF14077 Alternative WD40 repeat motif<br>Joint Center of Structural Genomics (JCSG). WD repeats are short subdomains of about 40 amino acids and fold into 4 antiparallel beta hairpins. This domain here has been detected on the C-terminus of WD repeat-containing protein 18 during target selection by the Joint Center for Structural Genomics.. 
+PF14078 Domain of unknown function (DUF4259)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 118 and 145 amino acids in length.. 
+PF14079 Domain of unknown function (DUF4260)<br>This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 126 amino acids in length. There is a conserved GLK sequence motif.. 
+PF14080 Domain of unknown function (DUF4261)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length.. 
+PF14081 Domain of unknown function (DUF4262)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 147 and 227 amino acids in length. Swiss:Q50763 is incorrectly annotated as the KatG protein.. 
+PF14082 Domain of unknown function (DUF4263)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 244 and 403 amino acids in length.. 
+PF14083 PGDYG protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved PGDYG motif.. 
+PF14084 Protein of unknown function (DUF4264)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14085 Domain of unknown function (DUF4265)<br>Jackhmmer:Chitinophaga pinensis . This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 139 and 168 amino acids in length.. 
+PF14086 Domain of unknown function (DUF4266)<br>This presumed lipoprotein domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 50 amino acids in length.. 
+PF14087 Domain of unknown function (DUF4267)<br>This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.. 
+PF14088 Domain of unknown function (DUF4268)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.. 
+PF14089 KinB-signalling pathway activation in sporulation<br>This family of small proteins is found in the membrane and is necessary for kinase KinB signalling during sporulation. There is a conserved GFF sequence motif. The initiation of sporulation in Bacillus subtilis is dependent on the phosphorylation of the Spo0A transcription factor mediated by the phospho-relay and by two major kinases, KinA and KinB.. 
+PF14090 Helix-turn-helix domain<br>This helix-turn-helix domain is often found in phage proteins and is likely to be DNA-binding.. 
+PF14091 Domain of unknown function (DUF4269)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved KTE sequence motif.. 
+PF14092 Domain of unknown function (DUF4270)<br>This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 444 and 534 amino acids in length.. 
+PF14093 Domain of unknown function (DUF4271)<br>This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 221 and 326 amino acids in length.. 
+PF14094 Domain of unknown function (DUF4272)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 221 and 399 amino acids in length.. 
+PF14096 Domain of unknown function (DUF4274)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length.. 
+PF14097 Stage V sporulation protein AE1<br>Members of this family are all described as putative stage V sporulation protein AE, although this could not be confirmed. Proteins in this family are approximately 190 amino acids in length.. 
+PF14098 Small, acid-soluble spore protein I<br>This family of proteins is putatively assigned as a small, acid-soluble spore protein 1.  Proteins in this family are approximately 70 amino acids in length. There is a conserved LPGLGV sequence motif.. 
+PF14099 Polysaccharide lyase<br>This family includes heparin lyase I, EC:4.2.2.7.\.   Heparin lyase I depolymerises heparin by cleaving the glycosidic linkage next to an iduronic acid moiety [1,2]. The structure of heparin lyase I consists of a beta-jelly roll domain with a long, deep substrate-binding groove and an unusual thumb domain containing many basic residues extending from the main body of the enzyme  . This family also includes glucuronan lyase, EC:4.2.2.14  . The structure glucuronan lyase is a beta-jelly roll  .. 
+PF14100 Methane oxygenase PmoA<br>This family is a putative methane oxygenase  . 
+PF14101 Domain of unknown function (DUF4275)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.. 
+PF14102 Capsule biosynthesis CapC<br>This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production  .. 
+PF14103 Domain of unknown function (DUF4276)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 224 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF14104 Domain of unknown function (DUF4277)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.. 
+PF14105 Domain of unknown function (DUF4278)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 58 and 136 amino acids in length. There is a single completely conserved residue R that may be functionally important.. 
+PF14106 Domain of unknown function (DUF4279)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.. 
+PF14107 Domain of unknown function (DUF4280)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 129 and 456 amino acids in length. There is a single completely conserved residue C that may be functionally important.. 
+PF14108 Domain of unknown function (DUF4281)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 147 and 232 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.. 
+PF14109 GldH lipoprotein<br>Members of this protein family are predicted lipoproteins, exclusive to the Bacteroidetes phylum. Proteins in this family are typically between 155 and 167 amino acids in length. Members include GldH, a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii  . Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Not all Bacteroidetes with members of this protein family may have gliding motility.. 
+PF14110 Domain of unknown function (DUF4282)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 93 and 155 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF14111 Domain of unknown function (DUF4283)<br>This domain family is found in plants, and is approximately 100 amino acids in length. Considering the very diverse range of other domains it is associated with it is possible that this domain is a binding/guiding region.  There are two highly conserved tryptophan residues.. 
+PF14112 Domain of unknown function (DUF4284)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 124 and 142 amino acids in length.. 
+PF14113 Domain of unknown function (DUF4285)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 157 and 206 amino acids in length.. 
+PF14114 Domain of unknown function (DUF4286)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 100 and 112 amino acids in length.. 
+PF14115 YuzL-like protein<br>The YuzL-like protein family includes the B. subtilis YuzL protein Swiss:C0H3R0 which is functionally uncharacterised. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.. 
+PF14116 YyzF-like protein<br>The YyzF-like protein family includes the B. subtilis YyzF protein Swiss:C0H3T9 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14117 Domain of unknown function (DUF4287)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 70 and 180 amino acids in length.. 
+PF14118 YfzA-like protein<br>The YfzA-like protein family includes the B. subtilis YfzA protein Swiss:C0H3X6 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.. 
+PF14119 Domain of unknown function (DUF4288)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF14120 YhzD-like protein<br>The YhzD-like protein family includes the B. subtilis YhzD protein Swiss:C0H3Y1 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved GKL sequence motif.. 
+PF14121 Domain of unknown function (DUF4289)<br>This family of membrane bet-barrel proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. Swiss:Q2S343 is identified by Gene3D as a membrane bound beta-barrel.. 
+PF14122 YokU-like protein<br>The YokU-like protein family includes the B. subtilis YokU protein Swiss:C0H434 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two conserved CXXC sequence motifs.. 
+PF14123 Domain of unknown function (DUF4290)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 200 and 221 amino acids in length. There are two conserved sequence motifs: EYGR and KLWD.. 
+PF14124 Domain of unknown function (DUF4291)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 190 and 214 amino acids in length. There are two conserved sequence motifs: VYQAY and RMTW.. 
+PF14125 Domain of unknown function (DUF4292)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.. 
+PF14126 Domain of unknown function (DUF4293)<br>This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 154 amino acids in length.. 
+PF14127 Domain of unknown function (DUF4294)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 192 and 226 amino acids in length.. 
+PF14128 Domain of unknown function (DUF4295)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (K and Y) that may be functionally important.. 
+PF14129 Domain of unknown function (DUF4296)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length.. 
+PF14130 Domain of unknown function (DUF4297)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is typically between 207 and 221 amino acids in length.. 
+PF14131 Domain of unknown function (DUF4298)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 94 and 105 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.. 
+PF14132 Domain of unknown function (DUF4299)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.. 
+PF14133 Domain of unknown function (DUF4300)<br>This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 281 and 303 amino acids in length. There are two conserved sequence motifs: NCR and PYQ.. 
+PF14134 Domain of unknown function (DUF4301)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 505 and 516 amino acids in length.. 
+PF14135 Domain of unknown function (DUF4302)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 344 and 443 amino acids in length. There are two completely conserved residues (R and L) that may be functionally important.. 
+PF14136 Domain of unknown function (DUF4303)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 169 and 192 amino acids in length.. 
+PF14137 Domain of unknown function (DUF4304)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 223 amino acids in length.. 
+PF14138 Cytochrome c oxidase assembly protein COX16<br>This family represents homologues of COX16   which has been shown to be involved in assembly of cytochrome oxidase  . Protein in this family are typically between 106 and 134 amino acids in length.. 
+PF14139 YpzG-like protein<br>The YpzG-like protein family includes the B. subtilis YpzG protein Swiss:C0H444 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a conserved QVNG sequence motif.. 
+PF14140 YpzI-like protein<br>The YpzI-like protein family includes the B. subtilis YpzI protein Swiss:C0H446 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.. 
+PF14141 YqzM-like protein<br>The YqzM-like protein family includes the B. subtilis YqzM protein Swiss:C0H453 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.. 
+PF14142 YrzO-like protein<br>The YrzO-like protein family includes the B. subtilis YrzO protein Swiss:C0H458 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.. 
+PF14143 YrhC-like protein<br>The YrhC-like protein family includes the B. subtilis YrhC protein Swiss:O05395 which is functionally uncharacterised. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine.  Expression of this operon is repressed in the presence of sulphate or cysteine  . This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF14144 Seed dormancy control<br>This family of plant proteins appears to be a highly specific controller seed dormancy.. 
+PF14145 YrhK-like protein<br>The YrhK-like protein family includes the B. subtilis YrhK protein Swiss:O05401 which is functionally uncharacterised.  Its expression is under the control of the motility sigma factor sigma-D  .  This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.. 
+PF14146 Domain of unknown function (DUF4305)<br>This family includes the B. subtilis YdiK protein Swiss:O05524, which is functionally uncharacterised.  This is not a homologue of E. coli YdiK, which belongs to Pfam:PF01594.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14147 Sporulation protein YhaL<br>This family of proteins is involved in sporulation. In B. subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E  .. 
+PF14148 YhdB-like protein<br>The YhdB-like protein family includes the B. subtilis YhdB protein Swiss:O07530, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 57 and 82 amino acids in length. There are two conserved sequence motifs: LMVRT and FLHAY.. 
+PF14149 YhfH-like protein<br>The YhfH-like protein family includes the B. subtilis YhfH protein Swiss:O07606, which is functionally uncharacterised. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response  .  This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 53 amino acids in length.. 
+PF14150 YesK-like protein<br>The YesK-like protein family includes the B. subtilis YesK protein Swiss:O31514, which is functionally uncharacterised.  Its expression is regulated by the sporulation-specific sigma factor sigma-E  .  This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.. 
+PF14151 YfhD-like protein<br>The YfhD-like protein family includes the B. subtilis YfhD protein Swiss:O31572, which is functionally uncharacterised.  Its expression is regulated by the sporulation-specific sigma factor sigma-F  .  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF14152 YfhE-like protein<br>The YfhE-like protein family includes the B. subtilis YfhE protein Swiss:O31573, which is functionally uncharacterised.  Its expression may be regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins  .  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved QEV sequence motif.. 
+PF14153 Spore coat protein CotO<br>Bacillus spores are protected by a protein shell consisting of over 50 different polypeptides, known as the coat.  This family of proteins has an important morphogenetic role in coat assembly, it is involved in the assembly of at least 5 different coat proteins including CotB, CotG, CotS, CotSA and CotW. It is likely to act at a late stage of coat assembly  .. 
+PF14154 Domain of unknown function (DUF4306)<br>This family includes the B. subtilis YjdJ protein Swiss:O05524, which is functionally uncharacterised.  This is not a homologue of E. coli YjdJ, which belongs to Pfam:PF00583.  This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 152 amino acids in length.. 
+PF14155 Domain of unknown function (DUF4307)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.. 
+PF14156 Antirepressor AbbA<br>This family inactivates the repressor AbrB, which represses genes switched on during the transition from the exponential to the stationary phase of growth.  It binds to AbrB and prevents it from binding to DNA  .. 
+PF14157 YmzC-like protein<br>The YmzC-like protein family includes the B. subtilis YmzC protein Swiss:O31797, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 91 amino acids in length. There is a conserved ELR sequence motif.. 
+PF14158 YndJ-like protein<br>The YndJ-like protein family includes the B. subtilis YndJ protein Swiss:O31813, which is functionally uncharacterised. This family is found in bacteria and archaea, and is typically between 222 and 269 amino acids in length. There are two completely conserved G residues that may be functionally important.. 
+PF14159 DUF4308;<br>CAAD domains of cyanobacterial aminoacyl-tRNA synthetase. This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids  . aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-, and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during evolution.. 
+PF14160 Centrosome-associated C terminus<br>This is the C-terminus of a family of proteins that colocalise with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.. 
+PF14161 Centrosome-associated N terminus<br>This is the N-terminus of a family of proteins that colocalise with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.. 
+PF14162 YozD-like protein<br>The YozD-like protein family includes the B. subtilis YozD protein Swiss:O31863, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14163 Superinfection exclusion protein B<br>This family includes superinfection exclusion proteins. These proteins prevent the growth of superinfecting phage which are insensitive to repression. It aborts lytic development of superinfecting phage [1-3].. 
+PF14164 YqzH-like protein<br>The YqzH-like protein family includes the B. subtilis YqzH protein Swiss:O32014, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14165 YtzH-like protein<br>The YtzH-like protein family includes the B. subtilis YtzH protein Swiss:O32066, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved DIL sequence motif.. 
+PF14166 YueH-like protein<br>The YueH-like protein family includes the B. subtilis YueH protein Swiss:O32093, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF14167 YfkD-like protein<br>The YfkD-like protein family includes the B. subtilis YfkD protein Swiss:O34579, which is functionally uncharacterised.  Its expression is regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins, and by the forespore-specific sigma factor sigma-G [1,2]. This family of proteins is found in bacteria. Proteins in this family are typically between 254 and 265 amino acids in length.. 
+PF14168 YjzC-like protein<br>The YjzC-like protein family includes the B. subtilis YjzC protein Swiss:O34585, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14169 Cold-inducible protein YdjO<br>This family includes the B. subtilis YdjO protein Swiss:O34759, which is functionally uncharacterised. This is not a homologue of E. coli YdjO, Swiss:P76210.  B. subtilis YdjO is cold-inducible  . Its expression is induced by the extracytoplasmic function sigma factor sigma-W  .  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.. 
+PF14171 Toxin SpoIISA, type II toxin-antitoxin system<br>SpoIISA is a toxin which causes lysis of vegetatively growing cells.  It forms part of a type II toxin-antitoxin system, where the SpoIISB protein, Pfam:PF14185, acts as an antitoxin. It is a transmembrane protein, with a cytoplasmic domain accounting for approximately two-thirds of the protein. The structure of the cytoplasmic domain resembles that of the GAF domains, Pfam: PF01590. SpoIISB binds to the cytoplasmic domain of SpoIISA with high affinity  .. 
+PF14172 Domain of unknown function (DUF4309)<br>This family includes the B. subtilis YjgB protein Swiss:O34960, which is functionally uncharacterised. This is not a homologue of E. coli YjgB, Swiss: P27250. Expression of B. subtilis YjgB is regulated by the alternative transcription factor sigma-B  . This family is found in bacteria, and is approximately 140 amino acids in length.. 
+PF14173 ComG operon protein 7<br>This family is required for DNA-binding during transformation of competent bacterial cells  .. 
+PF14174 YycC-like protein<br>The YycC-like protein family includes the B. subtilis YycC protein Swiss:P37481, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a conserved HIL sequence motif.. 
+PF14175 YaaC-like Protein<br>The YaaC-like protein family includes the B. subtilis YaaC protein Swiss:P37526, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 320 and 333 amino acids in length.. 
+PF14176 YxiJ-like protein<br>The YxiJ-like protein family includes the B. subtilis YxiJ protein Swiss:P42320, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF14177 YkyB-like protein<br>The YkyB-like protein family includes the B. subtilis YkyB protein Swiss:P42430, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There are two conserved sequence motifs: NRHAKTA and HLG.. 
+PF14178 YppF-like protein<br>The YppF-like protein family includes the B. subtilis YppF protein Swiss:P50834, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved LLDF sequence motif.. 
+PF14179 YppG-like protein<br>The YppG-like protein family includes the B. subtilis YppG protein Swiss:P50835, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.. 
+PF14181 YqfQ-like protein<br>The YqfQ-like protein family includes the B. subtilis YqfQ protein Swiss:P54474, also known as VrrA, which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 237 amino acids in length. There are two conserved sequence motifs: QYGP and PKLY.. 
+PF14182 YgaB-like protein<br>The YgaB-like protein family includes the B. subtilis YgaB protein Swiss:P71080, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.. 
+PF14183 YwpF-like protein<br>The YwpF-like protein family includes the B. subtilis YwpF protein Swiss:P94588, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.. 
+PF14184 Regulatory protein YrvL<br>YrvL prevents expression and activity of the YrvI sigma factor. It may function as an anti-sigma factor [1,2]. 
+PF14185 Antitoxin SpoIISB, type II toxin-antitoxin system <br>Members of this family act as antitoxins. They bind to the SpoIISA toxin, Pfam:PF14171. They are disordered proteins which adopt structure only when bound to SpoIISA  .. 
+PF14186 Cytoskeletal adhesion<br>This is the C-terminal domain of the axin-interacting protein family, and is a distinct version of the C2 domain. This domain is critical for interactions with cytoskeletal in the context of cellular adhesion points  .. 
+PF14187 Domain of unknown function (DUF4310)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 231 amino acids in length.. 
+PF14188 Domain of unknown function (DUF4311)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 260 amino acids in length.. 
+PF14189 Domain of unknown function (DUF4312)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 99 and 118 amino acids in length.. 
+PF14190 Domain of unknown function (DUF4313)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 171 amino acids in length.. 
+PF14191 YodL-like<br>The YodL-like protein family includes the B. subtilis YodL protein Swiss:O30472, which is functionally uncharacterised. This domain family is found in bacteria, and is approximately 100 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.. 
+PF14192 Domain of unknown function (DUF4314)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 56 and 93 amino acids in length.. 
+PF14193 Domain of unknown function (DUF4315)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.. 
+PF14194 Cysteine-rich VLP<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. It contains 6 conserved cysteines and a conserved VLP sequence motif.. 
+PF14195 Domain of unknown function (DUF4316)<br>This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 56 and 95 amino acids in length.. 
+PF14196 L-2-amino-thiazoline-4-carboxylic acid hydrolase<br>This family of enzymes catalyses the conversion of L-2-amino-delta2-thiazoline-4-carboxylic acid (L-ATC) to N-carbamoyl-L-cysteine  . It cleaves the carbon-sulphur bond in the ring structure of L-ATC to produce N-carbamoyl-L-cysteine  .. 
+PF14197 Centrosome localisation domain of PPC89 <br>The N-terminal region of the fission yeast spindle pole body protein PPC89 has low similarity to the human Cep57 protein. The CLD or centrosome localisation domain of Cep57 and PPC89 is found at the N-terminus. This region localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, Pfam:PF06657, is the microtubule-binding region of Cep57 and PPC89.. 
+PF14198 Transposon-encoded protein TnpV<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 114 and 125 amino acids in length.. 
+PF14199 Domain of unknown function (DUF4317)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 225 and 451 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF14200 Ricin-type beta-trefoil lectin domain-like<br>
+PF14201 Domain of unknown function (DUF4318)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a single completely conserved residue F that may be functionally important.. 
+PF14202 Transposon-encoded protein TnpW<br>This family of proteins is found in bacteria. Proteins in this family are typically between 54 and 75 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF14203 Domain of unknown function (DUF4319)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There are two completely conserved residues (E and K) that may be functionally important.. 
+PF14204 Ribosomal L18 C-terminal region<br>This domain is the C-terminal end of ribosomal L18/L5 proteins.. 
+PF14205 Cysteine-rich KTR<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length. There are 4 conserved cysteines and a conserved KTR sequence motif.. 
+PF14206 Cysteine-rich CPCC<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 68 and 104 amino acids in length. There are six conserved cysteines and a conserved CPCC sequence motif.. 
+PF14207 DpnD/PcfM-like protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 57 and 153 amino acids in length. There are two completely conserved residues (E and A) that may be functionally important.. 
+PF14208 Domain of unknown function (DUF4320)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 120 and 131 amino acids in length. There are two completely conserved residues (G and Y) that may be functionally important.. 
+PF14209 Domain of unknown function (DUF4321)<br>This family of proteins is functionally uncharacterised.  It is found in bacteria, and is approximately 50 amino acids in length.. 
+PF14210 Domain of unknown function (DUF4322)<br>This presumed domain is functionally uncharacterised. This domain family is found in archaea, and is approximately 60 amino acids in length. There is a conserved QTV sequence motif.. 
+PF14213 Domain of unknown function (DUF4325)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length.. 
+PF14214 Helitron helicase-like domain at N-terminus<br>This family is found in Helitrons, recently recognised eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.. 
+PF14215 bHLH-MYC and R2R3-MYB transcription factors N-terminal<br>This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, Pfam:PF00010. Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species (DOI:10.1007/s11295-009-0232-y).. 
+PF14216 Domain of unknown function (DUF4326)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.. 
+PF14217 Domain of unknown function (DUF4327)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.. 
+PF14218 Circadian oscillating protein COP23<br>This family includes the circadian oscillating protein COP23 from Cyanothece sp. (strain PCC 8801), Swiss:Q54702. The levels of this peripheral membrane protein display a circadian oscillation  .. 
+PF14219 Domain of unknown function (DUF4328)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 218 and 342 amino acids in length.. 
+PF14220 Domain of unknown function (DUF4329)<br>This domain is functionally uncharacterised.  It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with Pfam:PF05593 and Pfam:PF03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.. 
+PF14221 Domain of unknown function (DUF4330)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 165 and 177 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF14222 Cell morphogenesis N-terminal<br>This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.. 
+PF14223 gag-polypeptide of LTR copia-type<br>This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.. 
+PF14224 Domain of unknown function (DUF4331)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 526 amino acids in length. There is a conserved FPY sequence motif.. 
+PF14225 Cell morphogenesis C-terminal<br>This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.. 
+PF14226 non-haem dioxygenase in morphine synthesis N-terminal<br>This is the highly conserved N-terminal region of proteins with 2-oxoglutarate/Fe(II)-dependent dioxygenase activity.. 
+PF14227 gag-polypeptide of LTR copia-type<br>This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.. 
+PF14228 Cell morphogenesis central region<br>This family is the conserved central region of proteins that are involved in cell morphogenesis.. 
+PF14229 Domain of unknown function (DUF4332)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 134 and 356 amino acids in length. This domain contains helix-hairpin-helix motifs.. 
+PF14230 Domain of unknown function (DUF4333)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.. 
+PF14231 GXWXG protein<br>This domain is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. There is a conserved GXWXG motif. This domain is frequently found at the N-terminus of Pfam:PF14232.. 
+PF14232 Domain of unknown function (DUF4334)<br>This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. This domain is frequently found at the C-terminus of Pfam:PF14231.. 
+PF14233 Domain of unknown function (DUF4335)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 204 and 480 amino acids in length. There are two completely conserved residues (G and D) that may be functionally important.. 
+PF14234 Domain of unknown function (DUF4336)<br>
+PF14235 Domain of unknown function (DUF4337)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 201 amino acids in length. There is a single completely conserved residue Q that may be functionally important.. 
+PF14236 Domain of unknown function (DUF4338)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 206 and 475 amino acids in length.. 
+PF14237 Domain of unknown function (DUF4339)<br>This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.. 
+PF14238 Domain of unknown function (DUF4340)<br>This domain is found in bacteria, and is typically between 183 and 196 amino acids in length.. 
+PF14239 RRXRR protein<br>This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with Pfam:PF01844.. 
+PF14240 YHYH protein<br>This domain family is found in bacteria, eukaryotes and viruses, and is typically between 141 and 198 amino acids in length. There is a conserved YHYH sequence motif.. 
+PF14241 Domain of unknown function (DUF4341)<br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF04143. There are a number of conserved glycine residues that may be functionally important.. 
+PF14242 Domain of unknown function (DUF4342)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 97 and 206 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF14243 Domain of unknown function (DUF4343)<br>This domain family is found in bacteria, eukaryotes and viruses, and is typically between 127 and 142 amino acids in length.. 
+PF14244 gag-polypeptide of LTR copia-type<br>This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.. 
+PF14245 Type IV pilin PilA<br>Jackhmmer:Q59589, Jackhmmer:B0C6E0. This family consists of proteins which form type IV pili. In M. xanthus these pili are required for social motility [1,2].. 
+PF14246 AefR-like transcriptional repressor, C-terminal region<br>This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae  . It is found in association with Pfam:PF00440.. 
+PF14247 Domain of unknown function (DUF4344)<br>This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 247 and 291 amino acids in length. There is a conserved EED sequence motif.. 
+PF14248 Domain of unknown function (DUF4345)<br>This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 125 and 141 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF14249 Tocopherol cyclase<br>This family contains tocopherol cyclases. These enzymes are involved in the synthesis of tocopherols and tocotrienols (vitamin E)  .. 
+PF14250 AbrB-like transcriptional regulator<br>This family of DNA-binding proteins is likely to act as a transcriptional regulator  . This family does not include E.coli AbrB, Swiss:P75747, which belongs to Pfam:PF05145.. 
+PF14251 Domain of unknown function (DUF4346)<br>This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 127 and 502 amino acids in length. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and Swiss:Q57571 has been shown not to possess dihydropteroate synthase activity  .. 
+PF14252 Domain of unknown function (DUF4347)<br>This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.. 
+PF14253 Bacteriophage abortive infection AbiH<br>This family of proteins confers resistance to bacteriophage  .. 
+PF14254 Domain of unknown function (DUF4348)<br>
+PF14255 Cysteine-rich CPXCG<br>This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are 5 conserved cysteines which occur in a CPXCG motif and a DCXXCCXP motif.. 
+PF14256 YwiC-like protein<br>The YwiC-like protein family includes the B. subtilis YwiC protein Swiss:P46909, which is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF14257 Domain of unknown function (DUF4349)<br>This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 282 and 353 amino acids in length.  There is a single completely conserved residue D that may be functionally important.. 
+PF14258 Domain of unknown function (DUF4350)<br>This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.. 
+PF14259 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)<br>JCSG:Target_421663_WS20613B. 
+PF14260 C4-type zinc-finger of DNA polymerase delta<br>In fission yeast this zinc-finger domain appears is the region of Pol3 that binds directly to the B-subunit, Cdc1  .  Pol delta is a hetero-tetrameric enzyme comprising four evolutionarily well-conserved proteins: the catalytic subunit Pol3 and three smaller subunits Cdc1, Cdc27 and Cdm1  .. 
+PF14261 Domain of unknown function (DUF4351)<br>This domain is found in bacteria, and is approximately 60 amino acids in length.. 
+PF14262 Domain of unknown function (DUF4353)<br>This family is found in bacteria and archaea, and is typically between 262 and 279 amino acids in length.. 
+PF14263 Domain of unknown function (DUF4354)<br>JCSG:Target416839_SP17692A. Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop) proteins, but this could not be confirmed. The one PDB:3NRF structure solved for this family exhibits an immunoglobin-like beta-sandwich fold.  Crystal packing suggests that a tetramer is a significant oligomerisation state, and a disulfide bridge is formed between Cys 125 at the C-terminal end of the monomer, and Cys 69.. 
+PF14264 Glucosyl transferase GtrII<br>This family includes glucosyl transferase II from the Shigella phage SfII, Swiss:O21944, which mediates seroconversion of S. flexneri when the phage is integrated into the host chromosome  .. 
+PF14265 Domain of unknown function (DUF4355)<br>This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 180 and 214 amino acids in length.. 
+PF14266 Domain of unknown function (DUF4356)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 540 amino acids in length.. 
+PF14267 Domain of unknown function (DUF4357)<br>This domain family is found in bacteria and archaea, and is approximately 60 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.. 
+PF14268 YoaP-like<br>The YoaP-like domain is found at the C-terminus of the B. subtilis YoaP protein Swiss:O34983.  It is found in bacteria and archaea, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00583. There is a single completely conserved residue A that may be functionally important.. 
+PF14269 Arylsulfotransferase (ASST)<br>JCSG:Target416597_Pfam-B_1234 (release 25.0). 
+PF14270 Domain of unknown function (DUF4358)<br>This domain family is found in bacteria, and is approximately 110 amino acids in length.. 
+PF14271 Domain of unknown function (DUF4359)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. There are two completely conserved residues (P and S) that may be functionally important.. 
+PF14272 Glycine-rich SFCGS<br>This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There are a number of highly conserved motifs including an SFCGSGGAGA motif.. 
+PF14273 Domain of unknown function (DUF4360)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 200 and 228 amino acids in length. There is a conserved GCP sequence motif near the N-terminus.. 
+PF14274 Domain of unknown function (DUF4361)<br>JCSG:Target_416718_SP15308B. 
+PF14275 Domain of unknown function (DUF4362)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 93 and 146 amino acids in length. There is a conserved IRIV sequence motif.. 
+PF14276 Domain of unknown function (DUF4363)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.. 
+PF14277 Domain of unknown function (DUF4364)<br>This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 180 amino acids in length.. 
+PF14278 Transcriptional regulator C-terminal region<br>JCSG:Target403231_MJ9673J Pfam-B_17743 (release 25.0). This domain is a tetracycline repressor, domain 2, or C-terminus.. 
+PF14279 HNH endonuclease<br>This domain is related to other HNH domain families such as Pfam:PF01844. Suggesting that these proteins have a nucleic acid cleaving function.. 
+PF14280 Domain of unknown function (DUF4365)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.. 
+PF14281 PD-(D/E)XK nuclease superfamily<br>Members of this family belong to the PD-(D/E)XK nuclease superfamily.. 
+PF14282 FlxA-like protein<br>This family includes FlxA from E. coli, Swiss:P77609. The expression of FlxA is regulated by the FliA sigma factor, a transcription factor specific for class 3 flagellar operons. However FlxA is not required for flagellar function or formation  .. 
+PF14283 Domain of unknown function (DUF4366)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 227 and 387 amino acids in length.. 
+PF14284 PcfJ-like protein<br>The PcfJ-like protein family includes the E. faecalis PcfJ protein Swiss:Q5G3N2, which is functionally uncharacterised.  It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.. 
+PF14285 Domain of unknown function (DUF4367)<br>This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 229 and 435 amino acids in length.. 
+PF14286 DHHW protein<br>This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 404 amino acids in length. There is a conserved DHHW motif.. 
+PF14287 Domain of unknown function (DUF4368)<br>This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00239 and Pfam:PF07508. There is a single completely conserved residue G that may be functionally important.. 
+PF14288 1,3-beta-glucan synthase subunit FKS1, domain-1<br>The FKS1_dom1 domain is likely to be the 'Class I' region just N-terminal to the first set of transmembrane helices that is involved in 1,3-beta-glucan synthesis itself  . This family is found on proteins with family Glucan_synthase, Pfam:PF02364.. 
+PF14289 Domain of unknown function (DUF4369)<br>This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00578.. 
+PF14290 Domain of unknown function (DUF4370)<br>
+PF14291 Domain of unknown function (DUF4371)<br>
+PF14292 SusE outer membrane protein<br>This family includes the SusE outer membrane protein from Bacteroides thetaiotaomicron, Swiss:Q45769. This protein has a role in starch utilisation, but is not essential for growth on starch  .. 
+PF14293 YWFCY protein<br>This family is found in bacteria, and is approximately 60 amino acids in length. There is a conserved YWFCY motif. It is often found in association with Pfam:PF02534.. 
+PF14294 Domain of unknown function (DUF4372)<br>This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF01609.  There is a single completely conserved residue G that may be functionally important.. 
+PF14295 PAN domain<br>
+PF14296 O-antigen polysaccharide polymerase Wzy<br>This family includes O-antigen polysaccharide polymerases  . These enzymes link O-units via a glycosidic linkage to form a long O-antigen  . These enzymes vary in specificity and sequence  .. 
+PF14297 Domain of unknown function (DUF4373)<br>This domain is found in bacteria, eukaryotes and viruses, and is approximately 90 amino acids in length.. 
+PF14298 Domain of unknown function (DUF4374)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 406 and 466 amino acids in length.. 
+PF14299 Phloem protein 2<br>Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances  .. 
+PF14300 Domain of unknown function (DUF4375)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 156 and 204 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF14301 Domain of unknown function (DUF4376)<br>This domain family is found in bacteria and viruses, and is approximately 110 amino acids in length.. 
+PF14302 Domain of unknown function (DUF4377)<br>This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.. 
+PF14303 No apical meristem-associated C-terminal domain<br>This domain is found in a number of different types of plant proteins including NAM-like proteins.. 
+PF14304 Transcription termination and cleavage factor C-terminal<br>The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.. 
+PF14305 Glycos_tran_Wfd;<br>Eberhardt R, Iyer LM, Abhiman S, Burroughs AM, Aravind L. A member of the ATP-grasp fold predicted to be involved in the  biosynthesis of cell surface polysaccharides such as the O-antigen  in proteobacteria, the capsule in firmicutes and the polyglutamate chain of teichuronopeptide  . . 
+PF14306 PUA-like domain<br>This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes.. 
+PF14307 Glycosyltransferase WbsX<br>Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases [1,2].. 
+PF14308 X-domain of DnaJ-containing<br>IN certain plant and yeast proteins, the DnaJ-1 proteins have a three-domain structure.  The x-domain lies between the N-terminal DnaJ and the C-terminal Z domains. The exact function is not known.. 
+PF14309 Domain of unknown function (DUF4378)<br>
+PF14310 Fibronectin type III-like domain<br>This domain has a fibronectin type III-like structure  . It is often found in association with Pfam:PF00933 and Pfam:PF01915. Its function is unknown.. 
+PF14311 Domain of unknown function (DUF4379)<br>This domain is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. It contains a CXXCXH motif and a CPXC motif.. 
+PF14312 FG-GAP repeat<br>
+PF14313 N-terminal region of Paramyxovirinae phosphoprotein (P)<br>The soyouz module moiety is the N-terminal region of the phosphoprotein (P) from the subfamily Paramyxovirinae of the family Paramyxoviridae viruses. The main genera in this subfamily include the Rubulaviruses, avulaviruses, respiroviruses, henipaviruses, and morbilliviruses, all of which are enveloped viruses with a non-segmented, negative, single-stranded RNA genome encapsidated by the nucleoprotein (N) within a helical nucleocapsid.. 
+PF14314 Virus-capping methyltransferase<br>This is the methyltransferase region of the Mononegavirales single-stranded RNA viral RNA polymerase enzymes. This region is involved in the mRNA-capping of the virion particles.. 
+PF14315 Domain of unknown function (DUF4380)<br>This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 288 and 372 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.. 
+PF14316 Domain of unknown function (DUF4381)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 158 and 180 amino acids in length.. 
+PF14317 YcxB-like protein<br>The YcxB-like protein family includes the B. subtilis YcxB protein Swiss:Q08793, which is a functionally uncharacterised transmembrane protein.  This family of proteins is found in bacteria, and is approximately 60 amino acids in length.. 
+PF14318 Mononegavirales mRNA-capping region V<br>This V domain of L RNA-polymerase carries a new motif, GxxTx(n)HR, that is essential for mRNA cap formation. Nonsegmented negative-sense (NNS) RNA viruses, Mononegavirales, cap their mRNA by an unconventional mechanism. Specifically, 5'-monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate between the large polymerase protein L and mRNA. The V region is essential for this process  .. 
+PF14319 Transposase zinc-binding domain<br>This domain is likely to be a zinc-binding domain. It is found at the N-terminus of transposases belonging to the IS91 family.. 
+PF14320 Phosphoprotein P region PCT disordered<br>The N-terminal half of the phosphoprotein P of the Paramyxovirinae viruses.  The very first 60 residues have been built as the family Soyouz-module, Pfam:PF14313. The remaining part of the region, here, is disordered, and is liable to induced folding under the right physiological conditions. The region undergoes an unstructured-to-structured transition upon binding to Measles virus tail, C, unstructured region.. 
+PF14321 Domain of unknown function (DUF4382)<br>This family is found in bacteria and archaea, and is typically between 142 and 161 amino acids in length.. 
+PF14322 Starch-binding associating with outer membrane<br>JCSG:Target390309 Jackhmmer:Q8A1B4. SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.. 
+PF14323 GxGYxY sequence motif in domain of unknown function<br>This family carries a characteristic sequence motif, GxGYxYP, but is of unknown function. Associated families are sugar-processing domains.. 
+PF14324 PINIT domain<br>The PINIT domain is a protein domain that is found in PIAS proteins  . The PINIT domain is about 180 amino acids in length.. 
+PF14325 Domain of unknown function (DUF4383)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.. 
+PF14326 Domain of unknown function (DUF4384)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.. 
+PF14327 Hinge domain of cleavage stimulation factor subunit 2<br>The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localisation. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex.. 
+PF14328 Domain of unknown function (DUF4385)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 149 and 163 amino acids in length.. 
+PF14329 Domain of unknown function (DUF4386)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.. 
+PF14330 Domain of unknown function (DUF4387)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are approximately 110 amino acids in length. There is a conserved RSKN sequence motif.. 
+PF14331 ImcF-related N-terminal domain<br>This domain is found in bacterial ImcF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the ImcF-related domain, Pfam:PF06761.. 
+PF14332 Domain of unknown function (DUF4388)<br>This domain family is found in bacteria, and is typically between 102 and 135 amino acids in length.. 
+PF14333 Domain of unknown function (DUF4389)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 104 and 223 amino acids in length. There is a single completely conserved residue R that may be functionally important.. 
+PF14334 Domain of unknown function (DUF4390)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 192 and 203 amino acids in length.. 
+PF14335 Domain of unknown function (DUF4391)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 220 and 257 amino acids in length.. 
+PF14336 Domain of unknown function (DUF4392)<br>This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.. 
+PF14337 Domain of unknown function (DUF4393)<br>This family of proteins is found in bacteria, archaea and viruses.  Proteins in this family are typically between 254 and 285 amino acids in length.. 
+PF14338 Mrr N-terminal domain<br>This domain is found at the N-terminus of the Mrr restriction endonuclease catalytic domain, Pfam:PF04471 [1,2]. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition  .. 
+PF14339 Domain of unknown function (DUF4394)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 262 and 476 amino acids in length.. 
+PF14340 Domain of unknown function (DUF4395)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.. 
+PF14341 PilX N-terminal<br>This domain is found at the N-terminus of the PilX prepilin-like proteins which are involved in type 4 fimbrial biogenesis  .. 
+PF14342 Domain of unknown function (DUF4396)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 167 and 310 amino acids in length.. 
+PF14343 PrcB C-terminal<br>This domain is found at the C-terminus of Treponema denticola PrcB, Swiss:B8YNY4. PrcB interacts with the PrtP protease (dentilisin) and is required for the stability of the protease complex  .. 
+PF14344 Domain of unknown function (DUF4397)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.. 
+PF14345 GDYXXLXY protein<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 171 and 199 amino acids in length.  It contains a conserved GDYXXLXY motif.. 
+PF14346 Domain of unknown function (DUF4398)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 127 and 269 amino acids in length.. 
+PF14347 Domain of unknown function (DUF4399)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 135 and 1079 amino acids in length.. 
+PF14348 Domain of unknown function (DUF4400)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 209 and 249 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF14349 Motility related/secretion protein<br>This domain is found repeated three times in the N-terminal half of the gliding motility-related SprA proteins. The role of this domain in motility is uncertain  . It is also found in proteins required for secretion  .. 
+PF14350 Beta protein<br>This family includes the beta protein from Bacteriophage T4, Swiss:P13057. Beta protein prevents the gop protein, Swiss:P13058, from killing the bacterial host cell  .. 
+PF14351 Domain of unknown function (DUF4401)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with Pfam:PF09925.  There is a single completely conserved residue K that may be functionally important.. 
+PF14352 Domain of unknown function (DUF4402)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 182 amino acids in length.. 
+PF14353 CpXC protein<br>This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea, and is typically between 122 and 134 amino acids in length. It contains four conserved cysteines forming two CpXC motifs.. 
+PF14354 Restriction alleviation protein Lar<br>This family includes the restriction alleviation protein Lar encoded by the Rac prophage of Escherichia coli, Swiss:P33229. This protein modulates the activity of the Escherichia coli restriction and modification system  .. 
+PF14355 Abortive infection C-terminus<br>This domain is found at the C-terminus of the Lactococcus lactis abortive infection protein Abi-859, Swiss:Q48620. This protein confers bacteriophage resistance  .. 
+PF14356 Domain of unknown function (DUF4403)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 455 and 518 amino acids in length. There is a single completely conserved residue W that may be functionally important.. 
+PF14357 Domain of unknown function (DUF4404)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved residues (P and G) that may be functionally important.. 
+PF14358 Domain of unknown function (DUF4405)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There are two conserved histidines that may be functionally important. This family is N-terminally truncated compared to other members of the clan.. 
+PF14359 Domain of unknown function (DUF4406)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 98 and 145 amino acids in length.. 
+PF14360 PAP2 superfamily C-terminal<br>This family is closely related to the C-terminal a region of PAP2.. 
+PF14361 RsbT co-antagonist protein rsbRD N-terminal domain<br>This domain is found at the N-terminus of a number of anti-sigma-factor antagonist proteins including B. subtilis RsbRD, Swiss:P54504. These proteins are negative regulators of the general stress transcription factor sigma(B)  . It is found in association with Pfam:PF01740.. 
+PF14362 Domain of unknown function (DUF4407)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.. 
+PF14363 Domain associated at C-terminal with AAA<br>This domain is found in association with the AAA family, Pfam:PF00004.. 
+PF14364 Domain of unknown function (DUF4408)<br>This domain is found at the N-terminus of member of the DUF761 family Pfam:PF05553. Many members are plant proteins.. 
+PF14365 Domain of unknown function (DUF4409)<br>
+PF14366 Domain of unknown function (DUF4410)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 238 amino acids in length.. 
+PF14367 Domain of unknown function (DUF4411)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 153 and 170 amino acids in length. There is a single completely conserved residue D that may be functionally important.. 
+PF14368 Probable lipid transfer<br>The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.. 
+PF14369 zinc-finger<br>
+PF14370 C-terminal topoisomerase domain<br>This domain is found at the C-terminal of topoisomerase and other similar enzymes.. 
+PF14371 Domain of unknown function (DUF4412)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.. 
+PF14372 Domain of unknown function (DUF4413)<br>This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.. 
+PF14373 Superinfection immunity protein<br>This family includes the E. coli bacteriophage T4 superinfection immunity (imm) protein, Swiss:P08986. When E. coli is sequentially infected with two T-even type bacteriophage the DNA of the superinfecting phage is excluded from the host, into the periplasmic space. The immunity protein plays a role in this process  .. 
+PF14374 60S ribosomal protein L4 C-terminal domain<br>This family is found at the very C-terminal of 60 ribosomal L4 proteins.. 
+PF14375 Cysteine-rich CWC<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 74 and 102 amino acids in length. It contains eight conserved cysteines, including a conserved CWC sequence motif.. 
+PF14376 Haem-binding domain<br>This domain contains a potential haem-binding motif, CXXCH  . This family is found in association with Pfam:PF00034 and Pfam:PF03150.. 
+PF14377 Domain of unknown function (DUF4414)<br>This family is frequently found on DNA binding proteins of the URE-B1 type and on ligases.. 
+PF14378 PAP2 superfamily<br>
+PF14379 MYB-CC type transfactor, LHEQLE motif<br>This family is found towards the C-terminus of Myb-CC type transcription factors, and carries a highly conserved LHEQLE sequence motif.. 
+PF14380 Wall-associated receptor kinase C-terminal<br>This WAK_assoc domain is cysteine-rich and lies C-terminal to the binding domain, GUB_WAK_bind, Pfam:PF13947.. 
+PF14381 Ethylene-responsive protein kinase Le-CTR1<br>EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation  .. 
+PF14382 ECR11_N;<br>Exosome complex exonuclease RRP4 N-terminal region. ECR1_N is an N-terminal region of the exosome complex exonuclease RRP proteins. It is a G-rich domain which structurally is a rudimentary single hybrid fold with a permuted topology.. 
+PF14383 DUF761-associated sequence motif <br>This family is found frequently at the N-terminus of family DUF3741, Pfam:PF12552.. 
+PF14384 Domain of unknown function (DUF4415)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 82 and 104 amino acids in length.. 
+PF14385 Domain of unknown function (DUF4416)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved DPG sequence motif.. 
+PF14386 Domain of unknown function (DUF4417)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 220 and 340 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF14387 Domain of unknown function (DUF4418)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 132 and 150 amino acids in length.. 
+PF14388 Domain of unknown function (DUF4419)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 348 and 454 amino acids in length.. 
+PF14389 Leucine-zipper of ternary complex factor MIP1<br>This leucine-zipper is towards the N-terminus of MIP1 proteins. These proteins, here largely from plants, are subunits of the TORC2 (rictor-mTOR) protein complex controlling cell growth and proliferation  . The leucine-zipper is likely to be the region that interacts with plant MADS-box factors  ,. 
+PF14390 Domain of unknown function (DUF4420)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 310 and 334 amino acids in length.. 
+PF14391 Domain of unknown function (DUF4421)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 336 and 370 amino acids in length.. 
+PF14392 Zinc knuckle<br>The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. This particular family is found in plant proteins.. 
+PF14393 Domain of unknown function (DUF4422)<br>This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 255 and 371 amino acids in length.. 
+PF14394 Domain of unknown function (DUF4423)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 170 amino acids in length.. 
+PF14395 Phage phiEco32-like COOH.NH2 ligase-type 2<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. A family of COOH-NH2 ligases/GCS superfamily found in the neighborhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis  .. 
+PF14396 Cystic fibrosis TM conductance regulator (CFTR), regulator domain<br>
+PF14397 Sugar-transfer associated ATP-grasp<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. A member of the ATP-grasp fold predicted to be involved in the  biosynthesis of cell surface polysaccharides  .. 
+PF14398 YheC/D like ATP-grasp<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. A member of the ATP-grasp fold predicted to be involved in the  modification/biosynthesis of spore-wall and capsular proteins  .. 
+PF14399 BtrH;<br>NlpC/p60-like transpeptidase. Iyer LM, Abhiman S, Burroughs AM, Aravind L, Eberhardt R. Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases. They are predicted to function as transpeptidases in peptide metabolite biosynthesis  .. 
+PF14400 Inactive transglutaminase fused to 7 transmembrane helices<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. A family of inactive transglutaminases fused to seven transmembrane  helices. The transglutaminase domain is predicted to be extracellularly  located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The  ATP-grasp is predicted to modify the 7TM protein or a cofactor that  interacts with it  .. 
+PF14401 RimK-like ATPgrasp N-terminal domain<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. An uncharacterized alpha+beta fold domain that is mostly fused to a RimK-like ATP-grasp and is found in bacteria and euryarchaea. Members of this family are almost always associated in gene  neighborhoods with a GNAT-like acetyltransferase fused to a  papain-like petidase. Additionally M20-like peptidases, GCS2,  4Fe-4S Ferredoxins, a distinct metal-sulfur cluster protein and ribosomal proteins are found in the gene neighborhoods. Contextual analysis suggests a role for these in peptide biosynthesis  .. 
+PF14402 7 transmembrane helices usually fused to an inactive transglutaminase<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. A family of seven transmembrane helices fused to an inactive  transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it  .. 
+PF14403 Circularly permuted ATP-grasp type 2 <br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. Circularly permuted ATP-grasp prototyped by Roseiflexus RoseRS_2616  that is associated in gene neighborhoods with a GCS2-like COOH-NH2  ligase, alpha/beta hydrolase fold peptidase, GAT-II -like  amidohydrolase, and M20 peptidase. Members of this family are  predicted to be involved in the biosynthesis of small peptides  .. 
+PF14404 Ribosomally synthesized peptide in Streptomyces species<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. A ribosomally synthesized peptide related to microviridin and  marinostatin, usually in the gene neighborhood of one or more  RimK-like ATP-grasp. The gene-context suggests that it is further modified by the ATP-grasp. The peptide is predicted to  function in a defensive or developmental role, or as an antibiotic  .. 
+PF14406 Ribosomally synthesized peptide in Bacteroidetes<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to\. a papain-like domain. It is often present in multiple tandem  gene copies. The gene contexts suggest that it is modified by the  ATP-grasp as in the biosynthesis of microviridin and marinostatin.  They might function in defense or development or as peptide antibiotics  .. 
+PF14407 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. Ribosomally synthesized peptide linked to cyclases in chloroflexi.  It may have a link to cyclic nucleotide signaling  .. 
+PF14408 Ribosomally synthesized peptide in actinomycetes<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp and an aspartyl-O-methylase. Gene contexts suggest that it is further modified by the ATP-grasp  and the methylase. It might function in defense or development, or  as a peptide antibiotic  .. 
+PF14409 Ribosomally synthesized peptide in Herpetosiphon<br>Iyer LM, Abhiman S, Burroughs AM, Aravind L. Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to a papain-like domain. It is often present in multiple tandem gene  copies. Gene contexts suggest that it is modified by the ATP=grasp. It might function in defense or development, or as a peptide antibiotic  .. 
+PF14410 HNH/ENDO VII superfamily nuclease with conserved GHE residues<br>Zhang D, Iyer LM, Aravind L. A predicted nuclease of the HNH/EndoVII superfamily of the treble  clef fold which is closely related to the NucA-like family. The  name is derived from the conserved G, H and E residues. It is found in several bacterial polymorphic toxin systems  . Some GH-E members preserve the conserved cysteines of the treble-clef  suggesting that they might represent potential evolutionary  intermediates from a classical HNH domain to the derived NucA-like  form  .. 
+PF14411 A nuclease of the HNH/ENDO VII superfamily with conserved LHH<br>Zhang D, Iyer LM, Aravind L. LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems   and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved  histidines of which, the first one is predicted to bind metal-ion  and other three ones are involved in activation of water molecule for hydrolysis.. 
+PF14412 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH<br>Zhang D, Iyer LM, Aravind L. AHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, AHH. It is found in bacterial polymorphic toxin systems   and functions as a toxin module. Like WHH and LHH, the AHH nuclease contains 4  conserved histidines of which, the first one is predicted to bind  a metal-ion and the other three ones are involved in activation of a water molecule for hydrolysis.. 
+PF14413 Thg1 C terminal domain<br>Thg1 polymerases contain an additional region of conservation  C-terminal to the core palm domain that comprise of 5 helices and two strands  . This region has several well-conserved charged residues  including a basic residue found towards the end of the first helix  of this unit might contribute to the Thg1-specific active site  . This C-terminal module of Thg1 is predicted to form a helical bundle  that functions equivalently to the fingers of the other nucleic acid  polymerases, probably in interacting with the template HtRNA  .. 
+PF14414 A nuclease of the HNH/ENDO VII superfamily with conserved WHH<br>Zhang D, Iyer LM, Aravind L;. WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems   and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion  and other three ones are involved in activation of water molecule for hydrolysis  .. 
+PF14415 Domain of unknown function (DUF4424)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 310 and 361 amino acids in length.. 
+PF14416 PMR5 N terminal Domain<br>The plant family with PMR5, ESK1, TBL3 etc have a N-terminal   C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain  .. 
+PF14417 MEDS: MEthanogen/methylotroph, DcmR Sensory domain<br>MEDS is prototyped by DcmR and is likely to function with the PocR domain in certain organisms in sensing hydrocarbon derivatives    The MEDS domain occurs fused to Histidine Kinase and as standalone version  . Sequence analysis shows that it is a catalytically  inactive version of the P-loop NTPase domain of the RecA superfamily  .. 
+PF14418 OST-HTH Associated domain<br>OHA occurs with OST-HTH  . . 
+PF14419 SPOUT_MTase_11;<br>AF2226-like SPOUT RNA Methylase fused to THUMP. SPOUT superfamily RNA methylase fused to RNA binding THUMP domain  .. 
+PF14420 Clr5 domain<br>This domain is found at the N-terminus of the Clr5 protein which has been shown to be involved in silencing in fission yeast. This domain has been found to often be associated with proteins that contain ankyrin repeats and large regions of disordered sequence  .. 
+PF14421 CDD_CDA_1;<br>A distinct subfamily of CDD/CDA-like deaminases. Iyer LM, Zhang D, Aravind L. A distinct branch of the CDD/CDA-like deaminases prototyped by  Leishmania LmjF36.5940. Members of this family are widely distributed across several microbial eukaryotes such as kinetoplastids,  chlorophyte algae, stramenopiles and the alveolate Perkinsus. Domain  architectures suggest that these proteins might possess mRNA editing  or DNA mutagenizing activity  .. 
+PF14423 Immunity protein Imm5<br>Iyer LM, Zhang D, Aravind L.. A predicted Immunity protein, with an all-alpha fold, present in bacterial polymorphic toxin systems as an immediate neighbor of  the toxin   .. 
+PF14424 DEAM-TOXIN1;<br>The  BURPS668_1122 family of deaminases. Iyer LM, Zhang D, Aravind L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Burkholderia BURPS668_1122  . Members of this family are found as toxins in polymorphic toxin systems in a wide range of bacteria and in the eukaryote Perkinsus. Members of this family typically possess a DxE catalytic motif in Helix-2 of the core fold instead of the more common C[H]xE motif.  The Perkinsus versions are predicted to be inactive  .. 
+PF14425 Immunity protein Imm3<br>Iyer LM, Zhang D, Aravind L. A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene   .. 
+PF14426 Immunity protein Imm2<br>Iyer LM, Zhang D, Aravind L. A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene  .. 
+PF14427 Pput2613-DEAM;<br>Pput_2613-like deaminase. Iyer LM, Zhang D, Aravind L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Pseudomonas Pput_2613  . Members of this family are predicted to function as toxins in bacterial polymorphic toxin  systems   .. 
+PF14428 SCP1201-DEAM;<br>SCP1.201-like deaminase. Iyer LM, Zhang D, Aravind, L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Streptomyces SCP1.201  . Members of this family are predicted to function as toxins in bacterial polymorphic toxin  systems  .. 
+PF14429 C2 domain in Dock180 and Zizimin proteins<br>The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated  cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the  Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain   .. 
+PF14430 Immunity protein Imm1<br>Iyer LM, Zhang D, Aravind L. A predicted immunity protein, with an alpha+beta fold and a conserved C-terminal tryptophan residue. The protein is present in a wide range of bacteria in polymorphic toxin systems as an immediate gene  neighbor of the toxin gene  .. 
+PF14431 YwqJ-like deaminase<br>Iyer LM, Zhang D, Aravind L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Bacillus YwqJ  . Members of this family are present in a wide phyletic range of bacteria and a few basidiomycetes. Bacterial versions are predicted to function as toxins in bacterial  polymorphic toxin systems  .. 
+PF14432 DYW_Deaminase;<br>DYW family of nucleic acid deaminases. Iyer LM, Zhang D, Aravind, L. A family of nucleic acid  deaminases prototyped by the plant PPR DYW proteins that are implicated in chloroplast and mitochondrial RNA transcript maturation by numerous C to U editing events  . The  name derives from the DYW motif present at the C-terminus of the  classical plant PPR DYW deaminases. Members of this family are  present in bacteria, plants, Naegleria, and fungi  . Plants and  Naegleria show lineage-specific expansions of this family. The  classical DYW family contain an additional C-terminal metal-binding  cluster composed of 2 histidines and a CxC motif and are often fused to PPR repeats. Ascomycete versions, which are independent lateral  transfers, contain a large insert within the domain and are often fused to ankyrin repeats. Bacterial versions are predicted to  function as toxins in polymorphic toxin systems  .. 
+PF14433 SUKH-3 immunity protein<br>Zhang D, Iyer LM, Aravind L. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems  .. 
+PF14434 Immunity protein Imm6<br>Iyer LM, Zhang D, Aravind L. A predicted immunity protein, with an alpha+beta fold (mostly alpha  helices). The protein is present in polymorphic toxin systems as an  immediate gene neighbor of the toxin gene  .. 
+PF14435 SUKH-4 immunity protein<br>Zhang D, Iyer LM, Aravind L. This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems  .. 
+PF14436 Bacterial EndoU nuclease<br>Zhang D, Iyer LM, Aravind L. This is a bacterial verion of EndoU nuclease. It is found at C-terminal region of polymorphic toxin proteins. . 
+PF14437 MafB19-like deaminase<br>Iyer LM, Zhang D, Aravind L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Neisseria MafB19  . Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems  .. 
+PF14438 Ataxin 2 SM domain<br>Anantharaman V, Eberhardt R. This SM domain is found in Ataxin-2  .. 
+PF14439 Bd3614-like deaminase<br>Iyer LM, Zhang D, Aravind L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Bdellovibrio Bd3614  . They are typified by a  distinct N-terminal globular domain. The Bdellovibrio version occurs in a predicted operon with a 23S rRNA G2445-modifying  methylase suggesting that it might be involved in RNA editing  .. 
+PF14440 Xanthomonas XOO_2897-like deaminase<br>Iyer LM, Zhang D, Aravind L. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Xanthomonas XOO_2897  . Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems  . The Xanthomonas XOO_2897 lack an immunity protein and is predicted  to be deployed against its eukaryotic host  .. 
+PF14441 OTT_1508-like deaminase<br>Iyer LM, Zhang D, Aravind L, Eberhardt R. A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Orientia OTT_1508  . Members of this family are present in a wide phyletic range of bacteria,including several intracellular parasites and eukaryotes such as fungi, Leishmania,  Selaginella, and some apicomplexa. In bacteria, these deaminases are predicted to function as toxins in bacterial polymorphic toxin  systems  . Versions in intracellular bacteria lack immunity proteins and are likely to be deployed against their eukaryotic hosts. Eukaryotic versions are predicted to function as nucleic acid (either DNA or RNA) deaminases. Among eukaryotes, some fungi show  lineage-specific expansions of this family. Many fungal versions are  fused to a distinct N-terminal globular domain. Various fungal  versions are fused to domains involved in chromatin function.  Apicomplexan versions are fused to tRNA guanine transglycosylase  domain  . . 
+PF14442 Bd3614-N;<br>Bd3614-like deaminase N-terminal. Iyer LM, Zhang D, Aravind L. This is a globular domain that occurs N-terminal to the Bd3614-like deaminases, which are predicted to be involved in RNA editing  .. 
+PF14443 DBC1<br>DBC1 and it homologs from diverse eukaryotes are a catalytically  inactive version of the Nudix hydrolase (MutT) domain  . DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction  .. 
+PF14444 S1-like<br>S1-like RNA binding domain found in DBC1  . 
+PF14445 Prokaryotic RING finger family 2<br>Burroughs AM, Iyer LM, Aravind L. RING finger family found sporadically in bacteria and archaea, and  associated with other components of the ubiquitin-based signaling  and degradation system, including ubiquitin and the E1 and E2  proteins. The bacterial versions contain transmembrane helices  .. 
+PF14446 Prokaryotic RING finger family 1<br>Burroughs AM, Iyer LM, Aravind L. RING finger family found sporadically in bacteria and archaea, and  associated in gene neighborhoods with other components of the  ubiquitin-based signaling and degradation system, including  ubiquitin, the E1 and E2 proteins and the JAB-like metallopeptidase.  The bacterial versions contain transmembrane helices  .. 
+PF14447 Prokaryotic RING finger family 4<br>Burroughs AM, Iyer LM, Aravind L. RING finger family domain found sporadically in bacteria. The finger is fused to an N-terminal alpha-helical domain, ROT/Trove-like repeats and a C-terminal TerD domain  . The architecture suggests a possible role in an RNA-processing complex  .. 
+PF14448 NUC_N;<br>Zhang D, Iyer LM, Aravind L, Eberhardt R. Zhang D, Iyer LM, Aravind L. This is a conserved short region that is found in many bacterial polymorphic toxin proteins  . It is often located before C-terminal nuclease domains  .. 
+PF14449 Pre-toxin TG<br>Zhang D, Iyer LM, Aravind L, Eberhardt R. Zhang D, Iyer LM, Aravind L. PT-TG is a conserved region found in many bacterial toxin proteins. It could function as a linker that links N-terminal secretion-related domain and C-terminal toxin domain. It contains a TG motif  . . 
+PF14450 Cell division protein FtsA<br>Pfam-B_1177 (release 5.4). FtsA is essential for bacterial cell division, and co-localises to  the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains  .  The FtsA protein contains two structurally related  actin-like ATPase domains which are also structurally related to the ATPase domains of HSP70 (see PF00012). FtsA has a SHS2 domain  PF02491 inserted in to the RnaseH fold PF02491  .. 
+PF14451 Mut7-C ubiquitin<br>Iyer LM, Burroughs AM, Aravind L, Eberhardt R. This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role  .. 
+PF14452 Bac_multiUb;<br>Iyer LM, Burroughs AM, Aravind L, Eberhardt R. A ubiquitin superfamily domain that is often present in multiple  tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification  system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain  . The E2/UBC fold domain appears to be  inactive. The JAB domain in these operons is usually fused to  the E1 domain  .. 
+PF14453 ThiS-like ubiquitin <br>Iyer LM, Burroughs AM, Aravind L. A member of the ubiquitin superfamily that is often fused to the  ThiF-like (E1)- ubiquitin activating enzyme and is present in gene neighborhoods with components of the thiamine biosynthesis pathway  .. 
+PF14454 Prokaryotic Ubiquitin<br>Iyer LM, Burroughs AM, Aravind L. A Ubiquitin-superfamily protein that is present across several  bacterial lineages, and found in gene neighborhoods with components of the ubiquitin modification system such as the E1, E2 and JAB  proteins, and a novel alpha-helical protein, which is predicted  to be enzymatic  .. 
+PF14455 Predicted metal binding domain<br>Iyer LM, Burroughs AM, Aravind L. A predicted metal-binding domain that is found in gene-neighborhood associations with genes encoding components of the bacterial homologs of the ubiquitin modification pathway including the E1, E2, JAB  metallopeptidase and ubiquitin proteins. The domain is characterised  by a conserved motif with a CxxxxxEYHxxxxH signature.. 
+PF14456 Alpha-helical domain 2<br>Iyer LM, Burroughs AM, Aravind L. An alpha-helical domain found in gene neighborhoods encoding genes  containing bacterial homologs of components of the ubiquitin  modification pathway such as the E1, E2, Ub and JAB peptidase  proteins.. 
+PF14457 Prokaryotic E2 family A<br>Iyer LM, Burroughs AM, Aravind L. A member of the E2/UBC superfamily of proteins found in several bacteria. The active site residues are very similar to the eukaryotic E2 proteins [1,2]. Members of this family are usually fused to E1 and JAB domains C-terminal to the E2 domain. The protein is usually in the gene neighborhood of a gene encoding a distinct metallobetalactamase family protein  .. 
+PF14460 Prokaryotic E2 family D<br>Iyer LM, Burroughs AM, Aravind L. A member of the E2/UBC superfamily of proteins found in several  bacteria. Members of this family lack the conserved histidine  of the classical E2-fold. However, they have an absolutely conserved histidine carboxyl-terminal to the conserved cysteine [1,2]. Members  of this family are usually present in a conserved gene neighborhood  with genes encoding members of the Ub modification pathway such as  the E1, Ub and JAB proteins. These neighborhoods also contain a  gene encoding a rapidly diverging alpha-helical protein  .. 
+PF14459 Prokaryotic E2 family C<br>Iyer LM, Burroughs AM, Aravind L. A divergent member of the E2/UBC superfamily of proteins found in  bacteria. Members of the family contain a conserved cysteine in place of the histidine of the classical E2/UBC proteins [1,2]. Members of this family are usually fused to an E1 domain at their C-terminus. The protein is usually in the gene neighborhood of a gene encoding a JAB peptidase and another encoding a predicted metal binding domain  .. 
+PF14461 Prokaryotic E2 family B<br>Iyer LM, Burroughs AM, Aravind L. A member of the E2/UBC superfamily of proteins found in several  bacteria. The active site residues are  similar to the eukaryotic E2 proteins but lack the conserved asparagine [1,2]. Members of this family are usually fused to an E1 domain at the C-terminus. The protein is usually in the gene neighborhood of a gene encoding  a member of the pol-beta nucleotidyltransferase superfamily  . Many of the operons in this family are in ICE-like mobile elements and plasmids  .. 
+PF14462 Prokaryotic E2 family E<br>Iyer LM, Burroughs AM, Aravind L. A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteristic catalytic residues of the E2 enzymes [1,2]. They are usually fused  to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as  the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.. 
+PF14463 E1 N-terminal domain<br>Iyer LM, Burroughs AM, Aravind L. An uncharacterized alpha/beta domain fused to E1 proteins. This protein is usually present in gene neighborhoods with genes  encoding a JAB protein and a predicted metal-binding protein. In related E1 proteins, the E1-N domain is replaced by an E2/UBC superfamily domain  .. 
+PF14464 Prokaryotic homologs of the JAB domain<br>Iyer LM, Burroughs AM, Aravind L. These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes  . Prokaryotic JAB domains are predicted to  have a similar role in their cognates of the  ubiquitin modification pathway [2,3]. The domain is widely found in bacteria,  archaea and phages where they are present in several gene contexts  in addition to those that correspond to the prokaryotic cognates of the eukaryotic Ub pathway. Other contexts in which JAB domains are present include gene neighbor associations with ubiquitin fold  domains in cysteine and siderophore biosynthesis, and phage tail  morphogenesis, where they are shown or predicted to process the  associated ubiquitin [2,4]. A distinct family, the RadC-like JAB domains are widespread in bacteria and are predicted to function as nucleases  . In halophilic archaea the JAB domain shows strong  gene-neighborhood associations with a nucleotidyltransferase  suggesting a role in nucleotide metabolism  .. 
+PF14465 NFRKB Winged Helix-like<br>de novo domain prediction, confirmed by X-ray structure determination. This domain covers regions 370-495 of human nuclear factor related  to kappaB binding (NFRKB) protein.. 
+PF14466 Domain of unknown function (DUF4425) <br>BVU_3708 from Bacteroides vulgatus, JCSG target GS13500. A small family of bacterial proteins, found in several  Bacteroides species. Structure determination (NMR and Xray) shows an immunoglobulin beta barrel fold.\. Multiple homologs have been found  in human gut metagenomics data sets.. 
+PF14467 Domain of unknown function (DUF4426)<br>Pseudomonas aeruginosa PA0388, JCSG target SP19004A. Members of this entry are found mostly  in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase  RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine  biosynthesis protein MetW. On the other hand, in most Vibrio  species it appears as a part of a conserved operon involved in possible response to stress.. 
+PF14468 Protein of unknown function (DUF4427)<br>PSYMP_19184 [Pseudomonas syringae pv. morsprunorum str. M302280PT]. This domain is often found at the C-terminal of proteins with  Pfam:PF10899 domain, for instance in STY1911 protein from a  multiple drug resistant Salmonella enterica serovar Typhi CT18.. 
+PF14469 28 kDa A-kinase anchor <br>Jaroszewski L, Godzik A. Q86UN6 A-kinase anchor protein 14 isoform a [Homo sapiens]. 28 kDa AKAP (AKAP28) is highly enriched in human airway axonemes.  The mRNA for AKAP28 is up-regulated as primary airway cells  differentiate and is specifically expressed in tissues containing  cilia and/or flagella  . Homologs of AKAP28 are present in all  animals and in some, including mice the AKAP28-like domain are  preceded by another uncharacterized domain . 
+PF14470 Bacterial PH domain<br>Proteins in this family are distantly related to PH domains.. 
+PF14471 Domain of unknown function (DUF4428)<br>This putative zinc finger domain is found in uncharacterised bacterial proteins.. 
+PF14472 Domain of unknown function (DUF4429)<br>This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and viruses, and is approximately 90 amino acids in length.  This domain is often found in two tandem copies.. 
+PF14473 RD3 protein<br>RD3 is a human protein that is found preferentially expressed in the retina  .  Mutations in RD3 causes Leber Congenital Amaurosis type 12  .. 
+PF14474 RTC4-like domain<br>This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres  . This domain is also found in proteins that contain a DNA-binding myb domain.. 
+PF14475 Sec1-binding region of Mso1<br>Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction  , and this binding domain is towards the N-terminus of Mso1. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane  .  Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p  . The C-terminal region of Mso1 (not built) assists in targetting Sec1 to the sites of polarised membrane transport  .. 
+PF14476 Petal formation-expressed<br>Pfam-B_480 (release 25.0). The members of this plant family from Arabidopsis thaliana appear to be proteins found in the chloroplast, expressed in the pollen tube during the petal differentiation and expansion stage. The function is not known.. 
+PF14477 Membrane-polarising domain of Mso1<br>Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction  . The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane  . Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p  . This C-terminal region of Mso1 assists in targetting Sec1 to the sites of polarised membrane transport, the SNARES and Sec4  .. 
+PF14478 Domain of unknown function (DUF4430)<br>JCSG-Target:417407-SP17946A. Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.. 
+PF14479 Prion-inhibition and propagation<br>Greenwald J, Coggill P. Pfam-B_407 (release 25.0). This N-terminal region, HeLo, has a prion-inhibitory effect in cis on its own prion-forming domain (PFD) and in trans on HET-s prion propagation  . The domain is found exclusively in the fungal kingdom. Its structure, as it occurs in the HET-s/HET-S proteins, consists of two bundles of alpha-helices that pack into a single globular domain  .  The domain boundary determined from its structure and from protease-resistance experiments overlaps with the C-terminal prion-forming domain of HET-s (PF11558  . The HeLo domains of HET-s and HET-S are very similar and their few differences (and not the prion-forming domains) determine the compatibility-phenotype of the fungi in which the proteins are expressed. The mechanism of the HeLo domain-function in heterokaryon-incompatibility is still under investigation, however the HeLo domain is found in similar protein architectures as other cell death and apoptosis-inducing domains. The only other HeLo protein to which a function has been associated is LopB from L. maculans  .  Although its specific role in L. maculans is unknown, LopB- mutants have impaired ability to form lesions on oilseed rape. The HeLo domain is not related to the HET domain (PF06985) which is another domain involved in heterokaryon incompatibility.. 
+PF14480 DNA polymerase III polC-type N-terminus I<br>Pfam-B_853 (release 23.0). This is the first N-terminal domain, NI domain, of the DNA polymerase III polC subunit A that is found only in Firmicutes. DNA polymerase polC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria  .  Purine asymmetry is a characteristic of organisms with a heterodimeric DNA polymerase III alpha-subunit constituted by polC which probably plays a direct role in the maintenance of strand-biased gene distribution; since, among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased  . It has been predicted that the N-terminus of polC folds into two globular domains, NI and NII. A predicted patch of elecrostatic potential at the surface of this domain suggests a possible involvement in nucleic acid binding  . This domain is associated with DNA_pol3_alpha Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF11490.. 
+PF14481 Type 4 fimbrial biogenesis protein PilY2<br>Jaroszewski L, Godzik A. Pseudomonas aeruginosa PAO1 gene PA4555, JCSG target SP18988A. Members of this family were experimentally shown to be involved  in fimbrial biogenesis, but its exact role appears to be unknown.. 
+PF14482 Cut8 proteasome-binding domain<br>In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome  . Cut8 comprises three functional domains. An N-terminal lysine-rich segment (this entry) which binds to the proteasome when ubiquitinated, a central dimerisation domain (Pfam:PF14483) and a C-terminal six-helix bundle (Pfam:PF08559), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding  . Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8  . Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome  . In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1  . Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum  .. 
+PF14483 Cut8 dimerisation domain<br>In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome  . Cut8 comprises three functional domains. An N-terminal lysine-rich segment (Pfam:PF14482) which binds to the proteasome when ubiquitinated, a central dimerisation domain (this entry) and a C-terminal six-helix bundle (Pfam:PF08559), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding  . Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8  . Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome  . In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1  . Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum  .. 
+PF14484 Fish-specific NACHT associated domain<br>This domain is frequently found associated with the NACHT domain (Pfam:PF05729) in fish and other vertebrates  .. 
+PF14485 Domain of unknown function (DUF4431)<br>
+PF14486 Domain of unknown function (DUF4432)<br>JCSG_target390294_A6THE6. 
+PF14487 Domain of unknown function (DUF4433)<br>This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 201 and 230 amino acids in length. There is a single completely conserved residue E that may be functionally important. This family is distantly similar to Pfam:PF01885 suggesting these may be ADP-ribosylases.. 
+PF14488 Domain of unknown function (DUF4434)<br>JCSG_Target_393000_GS13553A. 
+PF14489 QueF-like protein<br>This protein is involved in the biosynthesis of queuosine.  In some proteins this domain appears to be fused to Pfam:PF06508.. 
+PF14490 Helix-hairpin-helix containing domain<br>This presumed domain contains at least one helix-hairpin-helix motif. This domain is often found in RecD helicases.. 
+PF14491 Protein of unknown function (DUF4435)<br>This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 285 and 362 amino acids in length. This domain is sometimes associated with AAA domains.. 
+PF14492 Elongation Factor G, domain II<br>This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679).. 
+PF14493 Helix-turn-helix domain<br>This presumed domain is found at the C-terminus of a large number of helicase proteins.. 
+PF14494 Domain of unknown function (DUF4436)<br>Pfam-B_6430 (release 25.0). This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.. 
+PF14495 Cytochrome c-550 domain<br>This domain is a heme binding cytochrome known as cytochrome c550, or cytochrome c549, or PsbV  .. 
+PF14496 C-terminal novel E3 ligase, LRR-interacting<br>Jackhmmer:E7K2H2_PDB:3ckd. This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred  .. 
+PF14497 Glutathione S-transferase, C-terminal domain<br>This domain is closely related to Pfam:PF00043.. 
+PF14498 Glycosyl hydrolase family 65, N-terminal domain<br>This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.. 
+PF14499 Domain of unknown function (DUF4437)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 152 and 283 amino acids in length.. 
+PF14500 Dos2-interacting transcription regulator of RNA-Pol-II<br>This domain, along with the C-terminal part, Pfam:PF12460  , is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly  .. 
+PF14501 GHKL domain<br>This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.. 
+PF14502 Helix-turn-helix domain<br>
+PF14503 YhfZ C-terminal domain<br>This domain is often found in association with the helix-turn-helix domain HTH_41 (Pfam:PF14502). It includes YhfZ proteins from Escherichia coli and Shigella flexneri.. 
+PF14504 CAP-associated N-terminal<br>JCSG:target_417453-SP18049A. The function of this domain is unknown, but it is found towards the N-terminus of bacterial proteins carrying the CAP domain, Pfam:PF00188. All members that do not otherwise carry an additional Cu_amine_oxidN1, Pfam:PF07833, domain are likely to be extracellular as they start with a signal-peptide. Most other non-bacterial proteins with the CAP domain are allergenic  .. 
+PF14505 Domain of unknown function (DUF4438)<br>
+PF14506 CppA N-terminal<br>This is the N-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity [1,2]. It is often found associated with Pfam:PF14507.. 
+PF14507 CppA C-terminal<br>This is the C-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity [1,2]. It is often found associated with Pfam:PF14506.. 
+PF14508 Glycosyl-hydrolase 97 N-terminal<br>This N-terminal domain of glycosyl-hydrolase-97  contributes part of the active site pocket. It is also important for contact with the catalytic and C-terminal domains of the whole [2,3].. 
+PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation<br>Glycosyl-hydrolase-97 is made up of three tightly linked and highly conserved globular domains.  The C-terminal domain is found to be necessary for oligomerisation of the whole molecule in order to create the active-site pocket and the Ca++-binding site.. 
+PF14510 ABC-transporter extracellular N-terminal<br>Pfam-B_101 (release 25.0). This domain is found at the N-terminus of ABC-transporter proteins from fungi, plants to higher eukaryotes. It would appear to be an extracellular domain.. 
+PF14511 Type II restriction endonuclease EcoO109I<br>Coggill P, Eberhardt R. pdb_1wtd-Jackhmmer:Q9RPJ3. This is a family of Type II restriction endonucleases.. 
+PF14512 Putative TM nitroreductase<br>Jackhmmer:Q9X1S2_pdb:1vkw. Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.. 
+PF14513 Diacylglycerol kinase N-terminus<br>This domain is found at the N-terminus of diacylglycerol kinases.. 
+PF14514 Transcriptional regulator, TetR, C-terminal<br>This family comprises proteins that belong to the TetR family of transcriptional regulators. This family features the C-terminal region of these sequences, which does not include the N-terminal helix-turn-helix.. 
+PF14515 Haem-oxygenase-associated N-terminal helices<br>Jackhmmer:Q9HY91, pdb_3bjdA. This domain represents a pair of alpha helices, which are found at the N-terminus of some Haem-oxygenase globular domain.. 
+PF14516 AAA-like domain<br>This family of proteins are part of the AAA superfamily.. 
+PF14517 Tachylectin<br>This family of lectins binds N-acetylglucosamine and N-acetylgalactosamine and may be involved in innate immunity [1-3]. It has a five-bladed beta-propeller structure with five carbohydrate-binding sites, one per beta sheet  .. 
+PF14518 Iron-containing redox enzyme<br>Pfam-B_412 (release 26.0). The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase  .. 
+PF14519 Macro-like domain<br>Jachmmer_A6ZME4, pdb_1njr. This domain is an ADP-ribose binding module.  It is found in a number of yeast proteins.. 
+PF14520 Helix-hairpin-helix domain<br>
+PF14521 Lysine-specific metallo-endopeptidase <br>Pfam-B_2237 (release 26.0), pdb_1g12 . This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS:M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054, His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner  .. 
+PF14522 Cytochrome c7<br>This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated. In c7-type the last haem is His-Met co-ordinated  .. 
+PF14523 Syntaxin-like protein<br>This domain includes syntaxin-like domains including from the Vam3p protein  .. 
+PF14524 Wzt C-terminal domain<br>This domain is found at the C-terminus of the Wzt protein  . The crystal structure of C-Wzt(O9a) reveals a beta sandwich with an immunoglobulin-like topology that contains the O-antigenic polysaccharide binding pocket. This domain is often associated with  the ABC-transporter domain.. 
+PF14525 AraC-binding-like domain<br>This domain is related to the AraC ligand binding domain Pfam:PF02311.. 
+PF14526 Integron-associated effector binding protein<br>This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown   to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.. 
+PF14527 WhiA LAGLIDADG-like domain<br>This domain is found within the sporulation regulator WhiA.  It is a LAGLIDADG superfamily like domain [1-2].. 
+PF14528 LAGLIDADG-like domain<br>This domain is part of the LAGLIDADG superfamily  .. 
+PF14529 Endonuclease-reverse transcriptase <br>This domain represents the endonuclease region of retrotransposons from a range of bacteria, archaea and eukaryotes.\. These are enzymes largely from class EC:2.7.7.49.. 
+PF14530 Domain of unknown function (DUF4439)<br>This domain has a ferritin-like fold.. 
+PF14531 Kinase-like<br>This family includes the pseudokinases ROP2 and ROP8 from Toxoplasma gondii (Swiss:Q06AK3 and Swiss:O15693). These proteins have a typical bilobed protein kinase fold, but lack catalytic actvity  .. 
+PF14532 Sigma-54 interaction domain<br>
+PF14533 Ubiquitin-specific protease C-terminal<br>Pfam-B_1954 (release 25.0). This C-terminal domain on many long ubiquitin-specific proteases has no known function.. 
+PF14534 Domain of unknown function (DUF4440)<br>
+PF14535 AMP-binding enzyme C-terminal domain<br>This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.. 
+PF14536 Domain of unknown function (DUF4441)<br>Pfam-B_1275 (release 25.0). This family is largely made up of uncharacterised proteins from the Ciliophora.  The function is not known.. 
+PF14537 Cytochrome c3<br>
+PF14538 Raptor N-terminal CASPase like domain<br>This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure  . It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.. 
+PF14539 Domain of unknown function (DUF4442)<br>This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 139 and 165 amino acids in length.  There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.. 
+PF14540 Nucleotidyltransferase-like<br>Structural comparisons with PDB:1kny indicate that this N-terminal domain resembles a nucleotidyltransferase fold.. 
+PF14541 Xylanase inhibitor C-terminal<br>The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylasnase.  Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.. 
+PF14542 GCN5-related N-acetyl-transferase<br>This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterised by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site.  It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.. 
+PF14543 Xylanase inhibitor N-terminal<br>The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylanase.\.       Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.. 
+PF14544 Domain of unknown function (DUF4443)<br>This is a family of archaeal proteins. The domain is a putative gyrase domain.. 
+PF14545 BCAP_N;<br>Dof, BCAP, and BANK (DBB) motif,. PROSITE, Pfam-B_2980 (release 26.0). The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerisation. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions  . Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling  .. 
+PF14547 Hydrophobic seed protein<br>This domain has a four-helix bundle structure. It contains four disulfide bonds, of which three function to keep the C- and N-terminal parts of the molecule in place  .. 
+PF14549 DNA-binding transcriptional regulator Cro<br>Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth.  It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.. 
+PF14550 Putative phage protease XkdF<br>Pfam-B_5816 (release 26.0). This domain is largely found on phage proteins.  In a number of cases the domain is associated with a SAM-dependent methyltransferase.. 
+PF14551 MCM N-terminal domain<br>This family contains the N-terminal region of MCM proteins.  This region is composed of three structural domains. Firstly a four helical bundle, secondly a zinc binding motif and thirdly an OB-like fold  .. 
+PF14552 Tautomerase enzyme<br>CATH:3c6vA00, Pfam-B_819 (release 26.0). 
+PF14553 YqbF, hypothetical protein domain<br>This N-terminal domain is found in Bacillus and related spp. The function is not known.. 
+PF14554 VEGF heparin-binding domain<br>This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.. 
+PF14555 UBA-like domain<br>
+PF14556 AF2331-like<br>AF2331-like is a 11-kDa orphan protein of unknown function from Archaeoglobus fulgidus. The structure consists of an alpha + beta fold formed by an unusual homodimer, where the two core beta-sheets are interdigitated, containing strands alternating from both subunits. AF2331 contains multiple negatively charged surface clusters and is located on the same operon as the basic protein AF2330. It is suggested that AF2331 and AF2330 may form a charge-stabilized complex in vivo, though the role of the negatively charged surface clusters is not clear.. 
+PF14557 Putative AphA-like transcriptional regulator<br>Members of this family are putative transcriptional regulators that appear to be related to the Pfam:PF03551 family. This family includes AphA-like members.. 
+PF14558 ML-like domain<br>This domain is distantly similar to Pfam:PF02221 and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding.. 
+PF14559 Tetratricopeptide repeat<br>
+PF14560 Ubiquitin-like domain<br>This entry contains ubiquitin-like domains [1-2].. 
+PF14561 Tetratricopeptide repeat<br>
+PF14562 Restriction endonuclease BglI<br>This restriction endonuclease binds DNA as a dimer. BglI recognises and cleaves the interrupted DNA sequence GCCNNNNNGGC and cleaves between the fourth and fifth unspecified base pair to produce 3' overhanging ends  .. 
+PF14563 Domain of unknown function (DUF4444)<br>This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved LIPL sequence motif. There are two completely conserved G residues that may be functionally important.. 
+PF14564 Membrane binding<br>This family includes the C-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 (Swiss:P54657), which has an immunoglobulin-like fold. It tethers the protein to the cell membrane  .. 
+PF14565 Interleukin 22 IL-10-related T-cell-derived-inducible factor<br>Interleukin-22 is distantly related to interleukin (IL)-10, and is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family.. 
+PF14566 Inositol hexakisphosphate<br>Pfam-B_194 (release 26.0). Inositol hexakisphosphate, often called phytate, is found in abundance in seeds and acting as an inorganic phosphate reservoir. Phytases are phosphatases that hydrolyze phytate to less-phosphorylated myo-inositol derivatives and inorganic phosphate. The active-site sequence (HCXXGXGR) of the phytase identified from the gut micro-organism Selenomonas ruminantium forms a loop (P loop) at the base of a substrate binding pocket that is characteristic of protein tyrosine phosphatases (PTPs). The depth of this pocket is an important determinant of the substrate specificity of PTPs. In humans this enzyme is thought to aid bone mineralization and salvage the inositol moiety prior to apoptosis  .. 
+PF14567 SMI1-KNR4 cell-wall<br>Pfam-B_7167 (release 26.0). Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.. 
+PF14568 SMI1-KNR4 cell-wall<br>Pfam-B_725 (releawse 26.0). Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.. 
+PF14569 Zinc-binding RING-finger<br>This RING/U-box type zinc-binding domain is frequently found in the catalytic subunit (irx3) of cellulose synthase. The enzymic class is EC:2.4.1.12, whereby the synthase removes the glucose from UDP-glucose and adds it to the growing cellulose, thereby releasing UDP. The domain-structure is treble-clef like (PDB:1weo).. 
+PF14570 RING/Ubox like zinc-binding domain<br>
+PF14571 Stress-induced protein Di19, C-terminal<br>C-terminal domain of Di19, a protein that increases the sensitivity of plants to environmental stress, such as salinity, drought, osmotic stress and cold. the protein is also induced by an increased supply of stress-related hormones such as abscisic acid ABA and ethylene  . There is a zinc-finger at the N-terminus, zf-Di19, Pfam:PF05605.. 
+PF14572 Phosphoribosyl synthetase-associated domain<br>pdb_2c4k; Jackhmmer:Q14558. This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.. 
+PF14573 Acyl-carrier<br>
+PF14574 Domain of unknown function (DUF4445)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 525 and 664 amino acids in length. The family is found in association with Pfam:PF00111.. 
+PF14575 Ephrin type-A receptor 2 transmembrane domain<br>Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor.  This domain oligomerises and is important for the active signalling process.. 
+PF14576 Sieve element occlusion N-terminus<br>Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation  . This domain represents the N-terminus of SEO proteins.. 
+PF14577 Sieve element occlusion C-terminus<br>Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation  . This domain represents the C-terminus of SEO proteins.. 
+PF14578 Elongation factor Tu domain 4<br>Elongation factor Tu consists of several structural domains, and this is usually the fourth.. 
+PF14579 Helix-hairpin-helix motif<br>The HHH domain is a short DNA-binding domain  .. 
+PF14580 Leucine-rich repeat<br>
+PF14581 SseB protein C-terminal domain<br>This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli   and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon  .\. This presumed domain is found at the C-terminus of SseB proteins.. 
+PF14582 Metallophosphoesterase, calcineurin superfamily<br>Members of this family are part of the Calcineurin-like phosphoesterase superfamily.. 
+PF14583 Oligogalacturonate lyase<br>This is a family of oligogalacturonate lyases, referred to more generally as pectate lyase family 22.  These proteins fold into 7-bladed beta-propellers.. 
+PF14584 Protein of unknown function (DUF4446)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 165 and 176 amino acids in length.. 
+PF14585 CagY type 1 repeat<br>This repeat is found at the N-terminus of the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells ( ).. 
+PF14586 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2<br>Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.. 
+PF14587 O-Glycosyl hydrolase family 30<br>
+PF14588 YjgF/chorismate_mutase-like, putative endoribonuclease<br>YjgF_Endoribonuc is a putative endoribonuclease. The structure is of beta-alpha-beta-alpha-beta(2) domains common both to bacterial chorismate mutase and to members of the YjgF family. These proteins form trimers with a three-fold symmetry with three closely-packed beta-sheets. The YjgF family is a large, widely distributed family of proteins of unknown biochemical function that are highly conserved among eubacteria, archaea and eukaryotes  .. 
+PF14589 Polysulfide reductase<br>CATH:2vpzC00, Pfam-B_200168. Bacterial polysulfide reductase is an integral membrane protein complex responsible for quinone-coupled reduction of polysulfide, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfides are a class of compounds composed of chains of sulfur atoms, which in their simplest form are present as an anion with general formula Sn(2-). In nature, polysulfides are found in particularly high concentrations in extreme volcanic or geothermically active environments. Here, the reduction and oxidation of polysulfides are vital processes for many bacteria and are essential steps in the global sulfur cycle. In particular, the reduction of polysulfide to hydrogen sulfide in these environments is usually linked to energy-generating respiratory processes, supporting growth of many microorganisms, particularly hyperthermophiles.. 
+PF14590 Domain of unknown function (DUF4447)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length.. 
+PF14591 NTP_transf_5;<br>Members of this family are of unknown function.. 
+PF14592 Chondroitinase B<br>This family includes chondroitinases. These enzymes cleave the glycosaminoglycan dermatan sulfate  .. 
+PF14593 PH domain<br>
+PF14594 Siphovirus ReqiPepy6 Gp37-like protein<br>This family includes numerous phage proteins from Siphoviruses. The function of this protein is uncertain, but it is related to Pfam:PF06605. In Rhodococcus phage ReqiPepy6 this protein is called Gp37  .. 
+PF14595 Thioredoxin<br>
+PF14596 STAT6 C-terminal<br>This family represents the C-terminus of mammalian STAT6 (Signal transducer and activator of transcription 6), it contains an LXXLL motif which binds to NCOA1 (Nuclear receptor coactivator 1)  .. 
+PF14597 Metallo-beta-lactamase superfamily<br>This is a small family of putative metal-dependent hydrolases.. 
+PF14598 PAS domain<br>This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6)  .. 
+PF14599 Zinc-ribbon<br>This is a typical zinc-ribbon finger, with each pair of zinc-ligands coming from more-or-less either side of two knuckles. It is found in eukaryotes.. 
+PF14600 Cellulose-binding domain<br>This C-terminal domain belongs to the CAZy family of carbohydrate-binding domains that are associated with glycosyl-hydrolases. It is suggested to bind cellulose.. 
+PF14601 DNA_binding protein, TFX, C-term<br>This is the C-terminal region of TFX-like DNA-binding proteins.. 
+PF14602 Hexapeptide repeat of succinyl-transferase<br>
+PF14603 Helically-extended SH3 domain<br>This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent.  It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides  . There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered  . The binding partners of the hSH3 domains are still unknown  .. 
+PF14604 Variant SH3 domain<br>Jackhmmer, JCSG:target_422527. 
+PF14605 Nup53/35/40-type RNA recognition motif<br>Jackhmmer, JCSG:target_422743. 
+PF14606 GDSL-like Lipase/Acylhydrolase family<br>Jackhmmer, JCSG:target_416889. 
+PF14607 N-terminus of Esterase_SGNH_hydro-type<br>Jackhmmer, JCSG_target_416889. This domain lies upstream of SGNH hydrolase, but its function is not known. There is a highly conserved GxDLY sequence-motif.. 
+PF14608 Zinc finger C-x8-C-x5-C-x3-H type<br>Pfam-B_880 (release 26.0). This is a zinc-finger of the type C-x8-C-x5-C-x3-H.. 
+PF14609 gamma-Tubulin ring complex non-core subunit mod21 <br>Pfam-B_276835 (release 26.0). GCP5-Mod21 is a non-core subunit of the larger gamma-tubulin ring complex that effects microtubule nucleation from both centrosomal and non-centrosomal sites. This subunit, unlike GCP2 and and GCP3 and others, is not thought to be essential for viability in the fission yeast, and may not be expressed in very high concentrations.  Fission yeast can form a large gamma-Tubulin complex C similar to that found in higher eukaryotes and this complex is important for maintaining normal levels of microtubule nucleation in vivo  .. 
+PF14610 GPI-anchored_2;<br>Protein of unknown function (DUF4448). Pfam-B_5686 (release 26.0). This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, Pfam:PF10342.. 
+PF14611 Mitochondrial inner-membrane-bound regulator<br>Pfam-B_1679 (release 26.00. SLS is a fungal domain found bound to the mitochondrial inner-membrane  . It reacts physically with fungal Kar2p to promote translocation across the endoplasmic-reticulum membrane. This action appeared to be mediated via the promotion of the Sec63p-mediated activation of Kar2p's ATPase activity. This indicates that the Sls1p protein is a GrpE-like protein in the endoplasmic reticulum. In S.cerevisiae the SLS1 gene (ScSLS1) is not essential but is also involved in ERAD and folding [2,3].. 
+PF14612 IEC3 subunit of the Ino80 complex, chromatin re-modelling<br>Pfam-B_3771 (release 26.0). This is a family of fungal chromatin re-modelling proteins found in one of the chromatin-central complexes, Ino80. The function was identified in Schizosaccharomyces pombe but there is no orthologue in S. cerevisiae. . 
+PF14613 Protein of unknown function (DUF4449)<br>Pfam-B_1378 (release 26.0). This is a fungal DUF of unknown function.. 
+PF14614 Domain of unknown function (DUF4450)<br>JCSG:Target_393004-GS13576A. This is a family of bacterial proteins of unknown function.. 
+PF14615 Ribosome-assembly protein 3<br>Pfam-B_11864 (release 26.0). This is a family of 60S ribosome-assembly proteins, from fungi.. 
+PF14616 Domain of unknown function (DUF4451)<br>Pfam-B_5126 (release 26.0). This is family of fungal proteins up-regulated during meiosis.. 
+PF14617 U3-containing 90S pre-ribosomal complex subunit<br>Pfam-B_3046 (release 26.0). This is a family of fungal and plant CMS1-like proteins. The family has similarity to the DEAD-box helicases. . 
+PF14618 Domain of unknown function (DUF4452)<br>Pfam-B_6056 (release 26.0). This fungal family has no known function. However, it is rich in paired, as CXXC, cysteines and histidines, but these do not fall in the conformation that might suggest zinc-binding.. 
+PF14619 Snf2-ATP coupling, chromatin remodelling complex<br>Pfam-B_4045 (release 26.0). This domain appears to play a crucial role in chromatin remodelling for yeast SWI/SNF. It binds histones. It is required for mobilising nucleosomes and lies within the catalytic subunit of the yeast SWI/SNF. It is found to be universally conserved  .. 
+PF14620 YpeB sporulation<br>Pfam-B_309 (release 26.0). YPEB is a protein that is necessary for the functioning of SleB during spore-cortex hydrolysis.. 
+PF14621 RFX5 DNA-binding domain<br>Pfam-B_20855 (release 26.0). RFX5 and RFXAP reveals molecular details associated with MHCII gene expression.. 
+PF14622 Ribonuclease-III-like<br>Pfam-B_6419 (release 26.0). Members of this family are involved in rDNA transcription and rRNA processing. They probably also cleave a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; they are involved in polyadenylation-independent transcription termination. Some members may be mitochondrial ribosomal protein subunit L15, others may be 60S ribosomal protein L3.. 
+PF14623 Hint-domain<br>This short domain is a conserved region of intein-containing proteins from lower eukaryotes. 
+PF14624 VWA / Hh  protein intein-like<br>Buerglin T, Coggill P. VWA-Hint proteins carry this conserved domain of around 300 residues, now named the Vwaint domain. Such proteins do not seem to have a signal peptide for secretion. Generally, this domain lies between the N-terminal VWA domain and the more C-terminal 'Vint'-type Hint domain. The exact function of this domain is not known.. 
+PF14625 Lustrin, cysteine-rich repeated domain<br>This repeated domain is found in proteins from lower eukaryotes in lustrin, perlucin, pearl nacre, and other similar protein-types. Each repeat lies between Kunitz-BPTI repeats, in certain species, which are also cysteine-rich. The cysteines may form the disulfide bonds observed for other members of this superfamily.. 
+PF14626 Zc3h12a-like Ribonuclease NYN domain<br>This family is found to be a divergent form of the NYN-domain- containing RNAse family.. 
+PF14627 Domain of unknown function (DUF4453)<br>This short domain is found only on a small subgroup of proteins from Gram-negative Proteobacteria that also carry a YARHG domain, Pfam:PF13308. They carry three conserved tryptophan and three conserved cysteine residues.. 
+PF14628 Domain of unknown function (DUF4454)<br>This C-terminal domain is found only on a small subgroup of proteins from Gram-positive Clostridiales that also carry a YARHG domain, Pfam:PF13308.. 
+PF14629 Origin recognition complex (ORC) subunit 4 C-terminus<br>This entry represents the C-terminus of origin recognition complex subunit 4 [1,2].. 
+PF14630 Origin recognition complex (ORC) subunit 5 C-terminus<br>This entry represents the C-terminus of origin recognition complex subunit 5  .. 
+PF14631 Fanconi anaemia protein FancD2 nuclease<br>The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.. 
+PF14632 Acidic N-terminal SPT6<br>pfam-B_9510 (release 26.0). The N-terminus of SPT6 is highly acidic. The full SPT6 protein is a transcription regulator, but the exact function of this acidic region is not certain.. 
+PF14633 SH2 domain<br>pfam-B_9510 (release 26.0). 
+PF14634 zinc-RING finger domain<br>
+PF14635 Helix-hairpin-helix motif\<br>Pfam-B_9510 (release 26.0). 
+PF14636 Folliculin-interacting protein N-terminus<br>This is the N-terminus of folliculin-interacting proteins [1,2].. 
+PF14637 Folliculin-interacting protein middle domain<br>This is the middle domain of folliculin-interacting proteins [1,2].. 
+PF14638 Folliculin-interacting protein C-terminus<br>This is the C-terminus of folliculin-interacting proteins [1,2]. This region is responsible for binding to folliculin  .. 
+PF14639 Holliday-junction resolvase-like of SPT6 <br>Pfam-B_9510 (release 26.0). The YqgF domain of SPT6 proteins is homologous to the E.coli RuvC   but its putative catalytic site lacks the carboxylate side chains critical for coordinating magnesium ions that mediate phosphodiester bond-cleavage  . 
+PF14640 Transmembrane protein 223<br>
+PF14641 HtH;<br>Helix-turn-helix DNA-binding domain of SPT6. Pfam-B_9510 (release 26.0). This helix-turn-helix represents the first of two DNA-binding domains on the SPT6 proteins.. 
+PF14642 FAM47 family<br>The function of this Chordate family of proteins is not known.. 
+PF14643 Domain of unknown function (DUF4455)<br>This domain family is found in bacteria and eukaryotes, and is approximately 480 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.. 
+PF14644 Domain of unknown function (DUF4456)<br>This domain family is found in bacteria and eukaryotes, and is approximately 210 amino acids in length. There is a single completely conserved residue E that may be functionally important.. 
+PF14645 Chibby family<br>This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila  .. 
+PF14646 MYCBP-associated protein family<br>This family of eukaryotic proteins includes the mammalian MYCBP-associated proteins. These proteins may be synaptic processes   and may have a role in spermatogenesis  .. 
+PF14647 FAM91 N-terminus<br>
+PF14648 FAM91 C-terminus<br>
+PF14649 Spatacsin C-terminus<br>This family includes the C-terminus of spatacsin.. 
+PF14650 FAM75 family<br>
+PF14651 Lipocalin / cytosolic fatty-acid binding protein family<br>Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).. 
+PF14652 Domain of unknown function (DUF4457)<br>This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.. 
+PF14653 Insulin growth factor-like family<br>This family includes the insulin growth factor-like proteins. These proteins are potential ligands for the IGFLR1 cell membrane receptor  .. 
+PF14654 Mucin_C;<br>Mucin, catalytic, TM and cytoplasmic tail region. Pfam-B_ 91014 (release 26.0). This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins  .. 
+PF14655 Rab3 GTPase-activating protein regulatory subunit N-terminus<br>This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily  .. 
+PF14656 Rab3 GTPase-activating protein regulatory subunit C-terminus<br>This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily  .. 
+PF14657 AP2-like DNA-binding integrase domain<br>This family includes AP2-like domains found in a variety of phage integrase proteins.  Presumably these domains are DNA-binding.. 
+PF14658 efhand_7;<br>
+PF14659 Phage integrase, N-terminal SAM-like domain<br>This domain is found in a variety of phage integrase proteins.. 
+PF14660 Domain of unknown function (DUF4458)<br>this domain is found in tandem repeats on the N-terminus of secreted LRR proteins from human associated Bacteroidetes domain boundaries are based on the JCSG solved 3D structure of JCSG target SP16667A (BT_0210). 
+PF14661 HAUS augmin-like complex subunit 6 N-terminus<br>This family includes the N-terminus of HAUS augmin-like complex subunit 6. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].. 
+PF14662 Coiled-coil region of CCDC155<br>This is a small family of eukaryotic proteins of unknown function.ThiS is the central coiled-coil region.. 
+PF14663 Rapamycin-insensitive companion of mTOR RasGEF_N domain<br>Pfam-B_389 (release 26.0). Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.. 
+PF14664 Rapamycin-insensitive companion of mTOR, N-term<br>Pfam-B_389 (release 26.0). Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.. 
+PF14665 Rapamycin-insensitive companion of mTOR, phosphorylation-site<br>Pfam-B_389 (release 26.0). Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site.  Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.. 
+PF14666 Rapamycin-insensitive companion of mTOR, middle domain<br>Pfam-B_389 (release 26.0). Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.. 
+PF14667 Polysaccharide biosynthesis C-terminal domain<br>This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.. 
+PF14668 Rapamycin-insensitive companion of mTOR, domain 5<br>Pfam-B_389 (release 26.0). Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.. 
+PF14669 Putative aspartate racemase<br>Pfam-B_34791 (release 26.0). This is a small family of vertebrate putative aspartate racemases. The family lies on TOPAZ 1 proteins.. 
+PF14670 Coagulation Factor Xa inhibitory site<br>Jackhmmer CATH:3kl6_B_0. This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442  .. 
+PF14671 Dual specificity protein phosphatase, N-terminal half<br>Jackhmeer:CATH:1ohe_A_01. The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, Pfam:PF00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity  .. 
+PF14672 Late cornified envelope <br>This is a family of late cornified envelope proteins that are expressed in skin  .. 
+PF14673 Domain of unknown function (DUF4459)<br>Pfam-B_10980 (release 26.0). This family appears only on sequences from Salmonella spp.  These sequences also all carry a YARHG domain, Pfam:PF13308.. 
+PF14674 FANCI solenoid 1 cap<br>This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein  .. 
+PF14675 FANCI solenoid 1<br>This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein  .. 
+PF14676 FANCI solenoid 2<br>This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein  .. 
+PF14677 FANCI solenoid 3<br>This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein  .. 
+PF14678 FANCI solenoid 4<br>This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein  .. 
+PF14679 FANCI helical domain 1<br>This is the helical domain 1 (HD1) of the Fanconi anemia group I protein  .. 
+PF14680 FANCI helical domain 2<br>This is the helical domain 2 (HD2) of the Fanconi anemia group I protein  .. 
+PF14681 Uracil phosphoribosyltransferase<br>This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.. 
+PF14682 Sporulation initiation phospho-transferase B, C-terminal<br>Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain, represented by this family. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate hereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor.. 
+PF14683 Polysaccharide lyase family 4, domain III<br>CBM-like is domain III of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain possesses a jelly roll beta-sandwich fold structurally homologous to carbohydrate binding modules (CBMs), and it carries two sulfate ions and a hexa-coordinated calcium ion.. 
+PF14684 Tricorn protease C1 domain<br>This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain  .. 
+PF14685 Tricorn protease PDZ domain<br>This domain is the PDZ domain of tricorn protease  .. 
+PF14686 Polysaccharide lyase family 4, domain II<br>FnIII-like is domain II of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain displays an immunoglobulin-like or more specifically Fibronectin-III type fold and shows highest structural similarity to the C-terminal beta-sandwich subdomain of the pro-hormone/propeptide processing enzyme carboxypeptidase gp180 from duck. It serves to assist in producing the deep pocket, with domain III, into which the substrate fits  .. 
+PF14687 Domain of unknown function (DUF4460)<br>This domain family is found in eukaryotes, and is typically between 103 and 119 amino acids in length. There is a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important.. 
+PF14688 Domain of unknown function (DUF4461)<br>This domain family is found in eukaryotes, and is approximately 310 amino acids in length.. 
+PF14689 Sensor_kinase_SpoOB-type, alpha-helical domain<br>Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, Pfam:PF14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.. 
+PF14690 zinc-finger of transposase IS204/IS1001/IS1096/IS1165<br>
+PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster<br>Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyses the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds  . This domain carries two Fe4-S4 clusters.. 
+PF14692 Domain of unknown function (DUF4462)<br>This domain family is found in eukaryotes, and is approximately 30 amino acids in length.. 
+PF14693 ShortName;<br>Ribosomal protein TL5, C-terminal domain. This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, Pfam:PF01386. Full length (N- and C-terminal domain) homologues of TL5 are also known as CTC proteins. TL5 or CTC are not found in Eukarya or Archaea. In some Bacteria, including E. coli, this ribosomal subunit occurs as a single domain protein (named Ribosomal subunit L25), where the only domain is homologous to TL5 N-terminal domain (hence included in family Pfam:PF01386). The function of the C-terminal domain of TLC is at present unknown.. 
+PF14694 Lines N-terminus<br>This family represents the N-terminus of protein lines  . In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator [2-3].. 
+PF14695 Lines C-terminus<br>This family represents the C-terminus of protein lines  . In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator [2-3].. 
+PF14696 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal <br>This domain is one of two barrel-shaped regions that together form the active enzyme, 4-hydroxyphenylpyruvic acid dioxygenase, EC:1.13.11.27. As can be deduced from the disposition of the various Glyoxalase families, _2, _3 and _4 in Pfam, Pfam:PF00903, Pfam:PF12681, Pfam:PF13468, Pfam:PF13669, these two regions are similar to be indicative of a gene-duplication event. At the individual sequence level slight differences in conformation have given rise to slightly different functions. In the case of UniProt:P80064, 4-hydroxyphenylpyruvic acid dioxygenase catalyses the formation of homogentisate from 4-hydroxyphenylpyruvate, and the pyruvate part of the HPPD substrate (4-hydroxyphenylpyruvate), derived from L-tyrosine, and the O2 molecule occupy the three free coordination sites of the catalytic iron atom in the C-terminal domain. In plants and photosynthetic bacteria, the tyrosine degradation pathway is crucial because homogentisate, a tyrosine degradation product, is a precursor for the biosynthesis of photosynthetic pigments, such as quinones or tocopherols  .. 
+PF14697 4Fe-4S dicluster domain<br>Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.. 
+PF14698 Argininosuccinate lyase C-terminal<br>This domain is found at the C-terminus of argininosuccinate lyase [1-2].. 
+PF14699 N-terminal domain from the human glycogen debranching enzyme<br>Jcakhammer:GDE_HUMAN. this domain is found on the very N-terminal of eukaryotic variant\.      of the glycogen debranching enzyme (GDE), where it is immediately  followe by the aldolase-like domain. The eukaryotic GDE performs  two functions: 4-α-D-glucanotransferase (EC 2.4.1.25) and  Amylo-α-1,6-glucosidase (EC 3.2.1.33), performed by the,  respectively N- and C- terminal halfs of eukaryotic GDE enzyme hGDE_N domain is involved in the glucosyltransferase activity,  probably\.     as a substrate binding module (by analogy to other  glucosyltransferases). 
+PF14700 DNA-directed RNA polymerase N-terminal<br>This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme  . In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex  .. 
+PF14701 glucanotransferase domain of human glycogen debranching enzyme<br>Jackhammer:GDE_HUMAN. this is a glucanotransferase catalytic domain of the eukaryotic  variant of the glycogen debranching enzyme (GDE).\. The eukaryotic GDEs performs two functions: 4-α-D-glucanotransferase  (EC 2.4.1.25) and Amylo-α-1,6-glucosidase (EC 3.2.1.33),\. performed by the, respectively N- and C- terminal halfs of  eukaryotic GDE enzymes. hDGE_amylase domain is a catalytic domain responsible for the glucanotransferase function. It belongs to the  alpha-amylase clan and is predicted to have a structure of a 8  stranded alpha/beta barrel (TIM barreal) where strands are  interuppted by long loops and additional mini-domains. In most other amylases, the catalytic domain is followed by a beta- barrel substrate binding domain, but presence of such domain cannot  be verified in the human (and other eukaryotic) GDE enzymes. 
+PF14702 central domain of human glycogen debranching enzyme<br>Jackhammer:GDE_HUMAN. this is a central domain of the eukaryotic variant      of the glycogen debranching enzyme (GDE). The eukaryotic GDE performs   two functions: 4-α-D-glucanotransferase (EC 2.4.1.25) and  Amylo-α-1,6-glucosidase (EC 3.2.1.33), performed by the,  respectively N- and C- terminal halfs of eukaryotic GDE enzyme The hGDE_central domain follows the glucanotransferas domain and  precedes the glucosidase (GDE_N) domain. It is very likely that the current definition contains two or more domains, by analogy  with baterial GDEs, this domain should be involved in substrate  binding either for the N-terminal glucanotransferase  and/or the the C-terminal glucosidase (or both) . 
+PF14703 Domain of unknown function (DUF4463)<br>This is a cytosolic (predicted) domain present in integral membrane  proteins, such as TM63C_HUMAN TRANSMEMBRANE PROTEIN 63C. This domain usually preceeds a DUF221 (PF02714)domain and follows  a RSN1_TM (PF13967) Fold recognition programs consistenly and with high significance  predict this domain to be distantly homologous to RNA binding  proteins from the RRM clan.. 
+PF14704 Dermatopontin<br>Members of this family mediate cell adhesion via cell surface integrin binding  . They also induce haemagglutination and aggregation of amebocytes [2-3].. 
+PF14705 Costars<br>This domain is found both alone and at the C-terminus of actin-binding Rho-activating protein (ABRA). It binds to actin, and in muscle regulates the actin cytoskeleton and cell motility [1-2]. It has a winged helix-like fold consisting of three alpha-helices and four antiparallel beta strands. Unlike typical winged helix proteins it does not bind to DNA, but contains a hydrophobic groove which may be responsible for interaction with other proteins  .. 
+PF14706 Transposase DNA-binding<br>This domain occurs at the C-terminus of transposases including E. coli tnpA (Swiss:Q46731). TnpA encodes a transposase and an inhibitor protein, the inhibitor only differs from the transposase by the absence of the N-terminal 55 amino acids, which includes most of this domain  . This domain consists of alpha helices and turns, and functions as a DNA-binding domain  .. 
+PF14707 C-terminal region of aryl-sulfatase<br>
+PF14709 double strand RNA binding domain from DEAD END PROTEIN 1<br>A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)   . 
+PF14710 Respiratory nitrate reductase alpha N-terminal<br>This is the N-terminal tail of the respiratory nitrate reductase alpha chain. The nitrate reductase complex is a dimer of heterotrimers each consisting of an alpha, beta and gamma chain. The N-terminal tail of the alpha chain interacts with the beta chain and contributes to the stability of the heterotrimer  .. 
+PF14711 Respiratory nitrate reductase beta C-terminal<br>This domain occurs near the C-terminus of the respiratory nitrate reductase beta chain. The nitrate reductase complex is a dimer of heterotrimers each consisting of an alpha, beta and gamma chain. This domain plays a role in the interactions between subunits and shielding of the Fe-S clusters  . 
+PF14712 Snapin/Pallidin<br>This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion  . It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting  . The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles  .. 
+PF14713 Domain of unknown function (DUF4464)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 224 and 241 amino acids in length. There is a conserved YID sequence motif.. 
+PF14714 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal<br>The KH-like domain at the C-terminus of the EngA subfamily of essential bacterial GTPases has a unique domain structure position. The two adjacent GTPase domains (GD1 and GD2), two domains of family MMR_HSR1, Pfam:PF01926, pack at either side of the C-terminal domain.  This C-terminal domain resembles a KH domain but is missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2.. 
+PF14715 N-terminal domain of cytochrome oxidase-cbb3, FixP <br>Pfam-B_28684 (release 26.0). This is the N-terminal domain of FixP, the cytochrome oxidase type-cbb3. the exact function is not known.. 
+PF14716 Helix-hairpin-helix domain<br>
+PF14717 Domain of unknown function (DUF4465)<br>JCSG structure SP13250B. A large family of uncharacterized proteins mostly from  human gut bacteroides, but also some environmental  and water bacteria (Planctomycetes) as well as  metagenomic samples Most proteins from this family are secreted or  located on the outer surface and may participate  in cell-cell interactions or cell-nutrient interactions This function is supported by a solved structure of a Bacteroides ovatus homolog, which adapts a galactose binding (jelly-roll) beta barrel structure. 
+PF14718 Soluble lytic murein transglycosylase L domain<br>Soluble lytic murein transglycosylase (SLT) consists of three domains, an N-terminal U domain, an L domain (linker domain) and a C-terminal domain (C). The L domain may be involved in the interaction of the enzyme with peptidoglycan  .. 
+PF14719 Phosphotyrosine interaction domain (PTB/PID)<br>
+PF14720 NiFe/NiFeSe hydrogenase small subunit C-terminal<br>This domain is found at the C-terminus of hydrogenase small subunits including periplasmic [NiFeSe] hydrogenase small subunit, uptake hydrogenase small subunit and periplasmic [NiFe] hydrogenase small subunit. This C-terminal domain binds two of the three iron-sulfur clusters in this enzyme [1-3].. 
+PF14721 Apoptosis-inducing factor, mitochondrion-associated, C-term<br>Jackhmmer:JCSG-Target_422903. This C-terminal domain appears to be a dimerisation domain of the mitochondrial apoptosis-inducing factor 1.  protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerisation and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.. 
+PF14722 SSFA2_N;<br>Ki-ras-induced actin-interacting protein-IP3R-interacting domain. This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein)  .  This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells  . It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function  .. 
+PF14723 Sperm-specific antigen 2 C-terminus<br>This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2  .. 
+PF14724 Mitochondrial-associated sphingomyelin phosphodiesterase<br>The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.. 
+PF14725 Domain of unknown function (DUF4466)<br>Jackhmmer-JCSG:target_419245-SP18803A. 
+PF14726 Rotatin, an armadillo repeat protein, centriole functioning <br>Pfma-B_645 (release 26.0). Rotatin and its homologues such as Ana3 in Drosophila are found to be essential for centriole function  . A deficiency of rotatin in mice leads to randomised heart tube looping, defects in embryonic turning  , and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homologue - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localises to centrioles and basal bodies and appears to be essential for cilia function  . This family represents the N-terminal domain.. 
+PF14727 PTHB1 N-terminus<br>This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis  .. 
+PF14728 PTHB1 C-terminus<br>This family includes the C-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis  .. 
+PF14729 Domain of unknown function with cystatin-like fold (DUF4467) <br>JCSG target SP18127A; Pfam-B_491 (release 26.0). Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan. 
+PF14730 Domain of unknown function (DUF4468) with TBP-like fold<br>Jackhammer: JCSG target SP13279C. A large family of (predicted) secreted proteins with unknown functions from human gut and oral cavity.\. Typically forms a N-terminal domain with FMN binding  domain at the C-terminus. Experimentaly determined 3D structure of this domain shows a variant of a TATA box binding - like fold, but no detectable  sequence similarity to other proteins with this fold. 
+PF14731 Staphopain proregion<br>This domain is the proregion of the cysteine protease staphopain. Like many papain type peptidases, staphopain is synthesised as an inactive precursor and cleavage of the proregion is required for activation. This proregion has a half-barrel or barrel-sandwich hybrid fold. The proregion blocks the active site cleft of the mature enzyme on one side of the nucleophilic cysteine  . 
+PF14732 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain<br>This is the C-terminal domain of ubiquitin-activating enzyme and SUMO-activating enzyme 2. It is structurally similar to ubiquitin. This domain is involved in E1-SUMO-thioester transfer to the SUMO E2 conjugating protein  .. 
+PF14733 AP2-coincident C-terminal<br>Woodcroft B, Eberhardt R. This family is found at the C-terminus of apicomplexan proteins containing the AP2 domain (Pfam:PF00847).. 
+PF14734 Domain of unknown function (DUF4469) with IG-like fold<br>Jackhammer:JCSG target GS13689A. A C-terminal domain in a large family of (predicted) secreted proteins with uknown functions from human gut bacteroides. 
+PF14735 HAUS augmin-like complex subunit 4<br>This family includes HAUS augmin-like complex subunit 4. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].. 
+PF14736 N_Asn_aminohyd;<br>Protein N-terminal asparagine amidohydrolase. This family of enzymes catalyse the deamindation of N-terminal asparagines in peptides and proteins to aspartic acid [1-2].. 
+PF14737 Domain of unknown function (DUF4470)<br>This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, Pfam:PF01753, at their very C-terminus. Others are also associated with DUF1279, Pfam:PF06916.. 
+PF14738 Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1<br>PAT1 (proton amino acid transporter 1), also known as TRAMD3 of AAT-1, is the molecular correlate of the intestinal imino acid carrier. It is a proton-amino acid co-transporter having a stoichiometry of 1:1. Due to its mechanism, PAT1 activity increases at acidic pH, which correlates well with the acidic micro-climate close to the brush-border in the intestine. Glycine, proline, and alanine are the preferred substrates of the transporter. The maximum velocity is similar for the three substrates. All substrates are transported with low affinity, showing Km values in the range of 2-10 mM. The transporter does not discriminate between L- and D-isoforms of these amino acids; in addition, beta-alanine is transported with similar affinity as alpha-alanine. Similar to the IMINO transporter, the amino acid analog MeAIB is recognized by PAT1. The transporter is strongly expressed in the small intestine, colon, kidney, and brain.. 
+PF14739 Domain of unknown function (DUF4472)<br>This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, Pfam:PF00225.. 
+PF14740 Domain of unknown function (DUF4471)<br>This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, Pfam:PF01753, at their very C-terminus. Others are also associated with DUF1279, Pfam:PF06916. This domain is more C-terminal in many members to DUF4470, Pfam:PF14737.. 
+PF14741 N-terminal glycosyl-hydrolase-114-associated domain<br>Naumoff D, Coggill P. This short domain is also a very small family found at the N-terminus of GH114, glycosyl-hydrolases.. 
+PF14742 N-terminal domain of (some) glycogen debranching enzymes<br>Jackhammer:YP_001865398. This domain is found on the N-terminal of some glycogen debranching  enzymes and is usually followed by the GDE_C (PF06202) and in this  sense it is analogous (but probably not homologous) to the GDE_N  (PF12439). Its exact function is unknown. 
+PF14743 DNA ligase OB-like domain<br>This domain has an OB-like fold, but does not appear to be related to Pfam:PF03120. It is found at the C-terminus of the ATP dependent DNA ligase domain Pfam:PF01068 [1-3].. 
+PF14744 WASH complex subunit 7<br>This family is the central, conserved region of proteins that form subunit 7 of the WASH complex  . In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes  .. 
+PF14745 WASH complex subunit 7, N-terminal<br>This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex  . In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes  .. 
+PF14746 WASH complex subunit 7, C-terminal<br>This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex  . In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes  . The C-terminus is predicted to include a transmembrane region.. 
+PF14747 Domain of unknown function (DUF4473)<br>Pfam-B_8489 (release 26.0). This short family is largely confined to Caenorhabditis proteins. The function is not known. There are two well-conserved aspartate residues.. 
+PF14748 Pyrroline-5-carboxylate reductase dimerisation<br>Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (Pfam:PF03807) and a C-terminal dimerisation domain. This is the dimerisation domain  .. 
+PF14749 Acyl-coenzyme A oxidase N-terminal<br>Acyl-coenzyme A oxidase consists of three domains. An N-terminal alpha-helical domain, a beta sheet domain (Pfam:PF02770) and a C-terminal catalytic domain (Pfam:PF01756). This entry represents the N-terminal alpha-helical domain  .. 
+PF14750 Integrator complex subunit 2<br>This family of proteins are subunits of the integrator complex involved in snRNA transcription and processing  .. 
+PF14751 Domain of unknown function (DUF4474)<br>Jackhmmer:JCSG target SP18061A. Domain found on N-termina of few families of uncharacterized  Clostridia proteins. Typically followed by a proline-rich domain  or other kinds of repeats. 
+PF14752 Retinol binding protein receptor<br>Proteins in this family function as retinol binding protein receptors  .. 
+PF14753 Domain of unknown function (DUF4475)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.. 
+PF14754 PPRSV-IRF3_ant;<br>Papain-like auto-proteinase. Pfam-B_8065 (release 26.0). The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase Pfam:PF05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.. 
+PF14755 Intracellular membrane remodeller <br>Pfam-B_2813 (release 26.0). This domain represents subunit nsp3 of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, and is a tetraspanning transmembrane protein that contains a cluster of four highly conserved cysteine residues. These are predicted to reside in the first luminal domain of the protein. Arterivirus nsp3 proteins are uniformly predicted to contain four transmembrane helices, with the N and C termini of the protein residing in the cytoplasm. NSP3 are localised to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus.. 
+PF14756 Peptidase_C33-associated domain<br>Pfam-B_535 (release 26.0). The nsps or non-structural protein subunits of the arteriviral polyproteins such as porcine arterivirus PRRSV and equine arterivirus EAV are auto-cleaved into functional units. the function of this particular domain is not known.. 
+PF14757 Immunogenic region of nsp2 protein of arterivirus polyprotein<br>Pfam-B_58 (release 26.0). This domain is in a non-essential part of the nsp2 (non-structural protein) subunit section of the arterivirus polyprotein. This domain carries seven small sequence-regions that are predicted to be potential B-cell epitopes.. 
+PF14758 Non-essential region of nsp2 of arterivirus polyprotein <br>Pfam-B_6704 (release 26.0) . This non-essential region of the nsp2 subunit of the arterivirus polyprotein of such as porcine arterivirus PRRSV and equine arterivirus EAV may offer immunogneic surfaces to B-cells. It is associated with Peptidase_C33, Pfam:PF05412.. 
+PF14759 Reductase C-terminal<br>This domain occurs at the C-terminus of various reductase enzymes, including putidaredoxin reductase, ferredoxin reductase, 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component, benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit, rhodocoxin reductase, biphenyl dioxygenase system ferredoxin--NAD(+) reductase component, rubredoxin-NAD(+) reductase and toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component. In putidaredoxin reductase this domain is involved in dimerisation  . In the FAD-containing NADH-ferredoxin reductase (BphA4) it is responsible for interaction with the Rieske-type [2Fe-2S] ferredoxin (BphA3)  .. 
+PF14760 Rnk N-terminus<br>This domain occurs at the N-terminus of Rnk, an RNA polymerase-interacting protein of the GreA/GreB family (Pfam:PF01272). It has a coiled coil structure  .. 
+PF14761 Hermansky-Pudlak syndrome 3<br>This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072  .. 
+PF14762 Hermansky-Pudlak syndrome 3, middle region<br>This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072  .. 
+PF14763 Hermansky-Pudlak syndrome 3, C-terminal<br>This domain is downstream of the mid domain family, Pfam:PF14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072  .. 
+PF14764 AP-5 complex subunit, vesicle trafficking<br>This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments  . There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs  .. 
+PF14765 Polyketide synthase dehydratase<br>Pfam-B_852 (release 26.0). This is the dehydratase domain of polyketide synthases  . Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products  .. 
+PF14766 Replication protein A interacting N-terminal<br>This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta [1-2].. 
+PF14767 Replication protein A interacting middle<br>This family of proteins represents the middle domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA [1-2].. 
+PF14768 Replication protein A interacting C-terminal<br>This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger [1-2].. 
+PF14769 Flagellar C1a complex subunit C1a-32<br>Jackhmmer:Q6P047, Pfam-B_2704 (release26.0). This family represents one small subunit, C1a-32, of the C1a projection (the seventh projection of flagellar)  . Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules in flagellar plays a distinct role in regulating eukaryotic ciliary/flagellar motility. The C1a projection is a complex of proteins including PF6, C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin. C1a projection is involved in modulating flagellar beat frequency and this is mediated via the C1a-34, C1a-32, and C1a-18 sub-complex by modulating the activity of both the inner and outer dynein arms  .. 
+PF14770 Transmembrane protein 18<br>The function of this family is not known, however it is predicted to be a three-pass membrane protein.. 
+PF14771 Domain of unknown function (DUF4476)<br>
+PF14772 Sperm tail<br>NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation  .. 
+PF14773 Helicase-associated putative binding domain, C-terminal<br>Jackhmmer:A4D997, Pfam-B_8865 (release 26.0). The function of this short, serine-rich C-terminal region is not known. However, as it is frequently found at the very C-terminus of P-loop containing nucleoside triphosphate hydrolases, it might possibly be a binding domain.. 
+PF14774 FAM177 family<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 205 amino acids in length.. 
+PF14775 Sperm tail C-terminal domain<br>NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation  . This short region is found at the very C-terminus of family members of family NYD-SP28, Pfam:PF14772.. 
+PF14776 Cation-channel complex subunit UNC-79<br>This family is a component of a cation-channel complex.. 
+PF14777 Cilia BBSome complex subunit 10<br>Jackhmmer:A8MTZ0, Pfam-B_35417 (release 26.0). The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme  . BBIP10 localises to the primary cilium, and is present exclusively in ciliated organisms. It is required for cytoplasmic microtubule polymerisation and acetylation, two functions not shared with any other BBSome subunits. BBIP10 physically interacts with HDAC6. BBSome-bound BBIP10 may therefore function to couple acetylation of axonemal microtubules and ciliary membrane growth  . The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction  .. 
+PF14778 Olfactory receptor 4-like<br>In C.elegans, odr-4 and odr-8 are required for localising a subset of odorant GPCRs to the cilia of olfactory neurons  . Olfactory receptors (ORs) are synthesised in endoplasmic reticulum of the olfactory neurons, trafficked to the cell surface membrane and transported to the tip of the olfactory cilium, where they bind with odorants. Various accessory proteins are required for proper targetting of different ORs to the cell membrane. ODR-4 was the first accessory protein to be described.. 
+PF14779 Ciliary BBSome complex subunit 1<br>The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme  . The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction  . BBS1 predominantly localizes to the basal body and or transitional zone of ciliated cells. It has been found in a heptameric complex with BBS2, BBS5, BBS7, BBS8, and BBS9, termed the BBSome. Mutations in BBS1 can lead to retinal inadequacy  .. 
+PF14780 Domain of unknown function (DUF4477)<br>Jackhmmer:Q6NW34, Pfam-B_4074 (release 26.0). 
+PF14781 Ciliary BBSome complex subunit 2, N-terminal<br>Pfam-B_5448 (release 26.0). The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme  . The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction  . BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia  .. 
+PF14782 Ciliary BBSome complex subunit 2, C-terminal<br>Pfam-B_5884 (release 26.0). The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme  . The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction  . BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia  .. 
+PF14783 Ciliary BBSome complex subunit 2, middle region<br>Pfam-B_5884 (release 26.0). The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme  . The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction  . BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia  .. 
+PF14784 C-terminal domain of the ECSIT protein<br>Jackhammer:Q9BQ95:268-396. This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain. 
+PF14785 Maltose transport system permease protein MalF P2 domain<br>This is the second periplasmic domain (P2 domain) of the maltose transport system permease protein MalF [1-2].. 
+PF14786 DEATH_2;<br>CATH:1d2z_B_00, Pfam-B_14779 (release 26.0). This Tube-Death domain has an insertion between helices 2 and 3, and a C-terminal tail compared with the Death domain of Pelle proteins in Drosophila. The two N-terminal Death domains of the serine/threonine kinase Pelle and the adaptor protein Tube interact to form a six-helix bundle fold arranged in an open-ended linear array with plastic interfaces mediating their interactions. This interaction leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis, and is assisted by the significant and indispensable contacts in the heterodimer contributed by the insertion and C-terminal tail described above  .. 
+PF14787 GAG-polyprotein viral zinc-finger<br>
+PF14788 EF hand<br>
+PF14789 Tetrahydrodipicolinate N-succinyltransferase middle<br>This is the middle domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase  .. 
+PF14790 Tetrahydrodipicolinate N-succinyltransferase N-terminal<br>This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase  .. 
+PF14791 DNA polymerase beta thumb <br>The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the thumb domain  .. 
+PF14792 DNA polymerase beta palm <br>The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain  .. 
+PF14793 Domain of unknown function (DUF4478)<br>This domain is found in bacteria, and is approximately 110 amino acids in length. It is found in association with Pfam:PF03641 and Pfam:PF11892.. 
+PF14794 Domain of unknown function (DUF4479)<br>This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01588.. 
+PF14795 Leucine-tRNA synthetase-specific domain<br>This short region is found only in leucyl-tRNA synthetases. It is flexibly linked to the enzyme-core by beta-ribbons structures  . 
+PF14796 Clathrin-adaptor complex-3 beta-1 subunit C-terminal<br>Pfam-B_195384 (release 26.0). This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules  .. 
+PF14797 Serine-rich region of AP3B1, clathrin-adaptor complex<br>Pfam-B_195384 (release 26.0). This short low-complexity, highly serine-rich region lies on clathrin-adaptor complex 3 beta-1 subunit proteins, between family Adaptin_N, Pfam:PF01602 and a C-terminal domain, AP3B1_C,Pfam:PF14796.. 
+PF14798 Calcium homeostasis modulator<br>This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels  .. 
+PF14799 FAM195 family<br>
+PF14800 Domain of unknown function (DUF4481)<br>
+PF14801 tRNA methyltransferase complex GCD14 subunit N-term<br>This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA  . The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.. 
+PF14802 TMEM192 family<br>The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome [1-2]. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time  .. 
+PF14803 Nudix N-terminal<br>Ths domain occurs at the N-terminus of several Nudix (Nucleoside Diphosphate linked to X) hydrolases.. 
+PF14804 Jag N-terminus<br>This domain is found at the N-terminus of proteins containing Pfam:PF13083 and Pfam:PF01424, including the jag proteins.. 
+PF14805 Tetrahydrodipicolinate N-succinyltransferase N-terminal<br>This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase  .. 
+PF14806 Coatomer beta subunit appendage platform<br>This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.. 
+PF14807 Adaptin AP4 complex epsilon appendage platform<br>Pfam-B_21377 (release 26.0). This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.. 
+PF14808 TMEM164 family<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 214 and 330 amino acids in length. There are two conserved sequence motifs: LNPCH and DPF.. 
+PF14809 C1 domain of tRNA-guanine transglycosylase dimerisation<br>This short region of the tRNA-guanine transglycosylase enzyme acts as the dimerisation domain of the whole protein  .. 
+PF14810 Patch-forming domain C2 of tRNA-guanine transglycosylase<br>Domain C2 of tRNA-guanine transglycosylase is formed by a four-stranded anti-parallel beta-sheet lined with two alpha helices. It has conserved basic residues on the surface of the beta-sheets as does the C-terminal domain PUA, Pfam:PF01472. The catalytic domain, TGT has conserved basic residues on the outer surface of the N-terminal three-stranded beta sheet, which closes the barrel, and it is postulated that these basic residues from the three domains form a continuous, positively charged patch to which the tRNA binds  .. 
+PF14811 Protein of unknown function TPD sequence-motif<br>This is a family of eukaryotic proteins of unknown function.  A few members have an associated zinc-finger domain. All members carry a highly conserved TPD sequence-motif.. 
+PF14812 Transmembrane domain of transglycosylase PBP1 at N-terminal<br>CATH:3fwl_A_01, Pfam-B_367 (release 26.0). This is the N-terminal, transmembrane, domain of the transglycosylases ()penicillin-binding proteins), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The TM domain is a single helix, several of whose residues lie in close proximity to hydrophobic residues in the TGT domain. The TM helix seems to be necessary for stabilizing the protein-membrane interaction, and the resulting orientation limits the interaction between PBPb1 and lipid II in the membrane in a 2D lateral diffusion fashion  .. 
+PF14813 NADH dehydrogenase 1 beta subcomplex subunit 2<br>This family represents an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis [1-2].. 
+PF14814 Bifunctional transglycosylase second domain<br>UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle  .. 
+PF14815 NUDIX domain<br>
+PF14816 Family of unknown function, FAM178<br>
+PF14817 HAUS augmin-like complex subunit 5<br>This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].. 
+PF14818 Domain of unknown function (DUF4482)<br>This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF11365.. 
+PF14819 Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term<br>The QueF monomer is made up of two ferredoxin-like domains aligned together with their beta-sheets that have additional embellishments. This subunit is composed of a three-stranded beta-sheet and two alpha-helices. QueF reduces a nitrile bond to a primary amine. The two monomer units together create suitable substrate-binding pockets  .. 
+PF14820 Small proline-rich 2<br>This family of small proteins is rich in proline, cysteine and glutamate. They contain a tandemly repeated nonamer, PKCPEPCPP  . They are components of the cornified envelope of keratinocytes  .. 
+PF14821 Threonine synthase N terminus<br>This domain is found at the N-terminus of many threonine synthase enzymes  .. 
+PF14822 Vasohibin<br>This family of proteins function as angiogenesis inhibitors in animals [1-2].. 
+PF14823 Sirohaem biosynthesis protein C-terminal<br>This domain is the C-terminus of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241  .. 
+PF14824 Sirohaem biosynthesis protein central<br>This is the central domain of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241  .. 
+PF14825 Domain of unknown function (DUF4483)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 326 amino acids in length. There is a single completely conserved residue N that may be functionally important.. 
+PF14826 FACT complex subunit SPT16 N-terminal lobe domain<br>The FACT or facilitator of chromatin transcription complex binds to and alters the properties of nucleosomes. This family represents the N-terminal lobe of the NTD, or N-terminal domain, and acts as a protein-protein interaction domain presumably with partners outside of the FACT complex  . Knockout of the whole NTD domain, 1-450 residues in UniProt:P32558, in yeast serves to tender the cells sensitive to DNA replication stress but is not lethal. The C-terminal half of NTD is structurally similar to aminopeptidases, and the most highly conserved surface residues line a cleft equivalent to the aminopeptidase substrate-binding site, family peptidase_M24, Pfam:PF00557  .. 
+PF14827 Sensory domain of two-component sensor kinase<br>CATH:3by8_A_00, Pfam-B_120 (release 26.0). Cache_3 is the periplasmic sensor domains of sensor histidine kinase of E. coli DcuS. This domain forms one of the components of the two-component signalling system that allows bacteria to adapt to changing environments. The ability of bacteria to monitor and adapt to their environment is crucial to their survival, and two-component signal transduction systems mediate most of these adaptive responses. One component is a histidine kinase sensor - this domain - most commonly part of a homodimeric transmembrane sensor protein, and the second component is a cytoplasmic response regulator. The two components interact in tandem through a phospho-transfer cascade  .. 
+PF14828 Amnionless<br>The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake  .. 
+PF14829 Glycerol-3-phosphate acyltransferase N-terminal<br>GPAT_N is the N-terminal domain of glycerol-3-phosphate acyltransferases, and it forms a four-helix bundle  . Glycerol-3-phosphate (1)-acyltransferase(G3PAT) catalyses the incorporation of an acyl group from either acyl-acyl carrier proteins or acyl-CoAs into the sn-1 position of glycerol 3-phosphate to yield 1-acylglycerol-3-phosphate. G3PATs can either be selective, preferentially using the unsaturated fatty acid, oleate (C18:1), as the acyl donor, or non-selective, using either oleate or the saturated fatty acid, palmitate (C16:0), at comparable rates. The differential substrate-specificity for saturated versus unsaturated fatty acids seen within this enzyme family has been implicated in the sensitivity of plants to chilling temperatures  . The exact function of this domain is not known. it lies upstream of family Acyltransferase, Pfam:PF01553.. 
+PF14830 Haemocyanin beta-sandwich<br>This antiparallel beta sandwich domain occurs in mollusc haemocyanins. Each mollusc haemocyanin contains several globular oxygen binding functional units. Each unit consists of an alpha-helical copper binding domain (Pfam:PF00264) and an antiparallel beta sandwich domain [1-2].. 
+PF14831 Domain of unknown function (DUF4484)<br>KOGs (KOG4704), PF09804. This domain is found, in a few members, a the the C-terminus of family Avl9, Pfam:PF09794. The function is not known.. 
+PF14832 Putative oxalocrotonate tautomerase enzyme<br>4-oxalocrotonate tautomerase enzyme is involved in the anthranilate synthase pathway.1. 
+PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase<br>3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidized to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold  .. 
+PF14834 Glutathione S-transferase, C-terminal domain<br>GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants.  Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain  .. 
+PF14835 zf-RING of BARD1-type protein<br>The RING domain of the breast and ovarian cancer tumour-suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. A dimer is formed between the RING domains of BRCA1 and BARD1. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level  . The corresponding BRCA1-RING domain is on family zf-C3HC4_2, Pfam:PF13923.. 
+PF14836 Ubiquitin-like domain<br>This ubiquitin-like domain is found in several ubiquitin carboxyl-terminal hydrolases   and in gametogenetin-binding protein.. 
+PF14837 Integrator complex subunit 5 N-terminus<br>This family of proteins represents the N-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing  .. 
+PF14838 Integrator complex subunit 5 C-terminus<br>This family of proteins represents the C-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing  .. 
+PF14839 DOR family<br>This family of proteins regulate autophagy and gene transcription  .. 
+PF14840 Processivity clamp loader gamma complex DNA pol III C-term<br>This domain lies at the C-terminus of the delta subunit of the DNA polymerase III clamp loader gamma complex. Within the complex the several C-terminal domains, of gamma, delta and delta' form a helical scaffold, on which the rest of he subunits are hung. The gamma complex, an AAA+ ATPase, is the bacterial homologue of the eukaryotic replication factor C that loads the sliding clamp (beta, homologous to PCNA) onto DNA.. 
+PF14841 FliG middle domain<br>This is the middle domain of the flagellar rotor protein FliG [1-2].. 
+PF14842 FliG N-terminal domain<br>This is the N-terminal domain of the flagellar rotor protein FliG  .. 
+PF14843 Growth factor receptor domain IV<br>This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030)  .. 
+PF14844 PH domain associated with Beige/BEACH<br>This PH domain is found in proteins containing the Beige/BEACH domain (Pfam:PF02138), it immediately precedes the Beige/BEACH domain  .. 
+PF14845 beta-acetyl hexosaminidase like<br>
+PF14846 Domain of unknown function (DUF4485)<br>This family is found in eukaryotes, and is approximately 90 amino acids in length.. 
+PF14847 Ras-binding domain of Byr2<br>CATH:1k8r_B_00, Pfam-B_3317 (release 26.0). This domain is the binding/interacting region of several protein kinases, such as the Schizosaccharomyces pombe Byr2. Byr2 is a Ser/Thr-specific protein kinase acting as mediator of signals for sexual differentiation in S. pombe by initiating a MAPK module, which is a highly conserved element in eukaryotes. Byr2 is activated by interacting with Ras, which then translocates the molecule to the plasma membrane. Ras proteins are key elements in intracellular signaling and are involved in a variety of vital processes such as DNA transcription, growth control, and differentiation. They function like molecular switches cycling between GTP-bound 'on' and GDP-bound 'off' states  .. 
+PF14848 DNA-binding domain<br>JCSG_Target_393235 / GS13689A, Pfam-B_2593 (release 26.0). 
+PF14849 YidC periplasmic domain<br>This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins [1,2].. 
+PF14850 DNA-binding domain of Proline dehydrogenase<br>This domain lies at the N-terminus of bifunctional proline-dehydrogenases and is found to bind DNA.. 
+PF14851 FAM176 family<br>Members of the FAM176 family regulate autophagy and apoptosis [1-2].. 
+PF14852 Fis1 N-terminal tetratricopeptide repeat<br>The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the N-terminal tetratricopeptide repeat [1-2]. 
+PF14853 Fis1 C-terminal tetratricopeptide repeat<br>The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat [1-2]. 
+PF14854 Leucine rich adaptor protein <br>
+PF14855 Pilus-assembly fibrillin subunit, chaperone<br>Pfam-B_9717 (release 26.0). PapJ is part of the Pap pilus assembly complex that plays an auxiliary role by ensuring the proper integration of PapA into the fimbrial shaft. PapA is the major shaft protein of the pilus.. 
+PF14856 Ecp2;<br>Pathogen effector; putative necrosis-inducing factor. Stergiopoulos I, Coggill P. The domain corresponds to the mature part of the Ecp2 effector protein from the tomato pathogen Cladopsorium fulvum. Effectors are low molecular weight proteins that are secreted by bacteria, oomycetes and fungi to manipulate their hosts and adapt to their environment. Ecp2 is a 165 amino acid secreted protein that was originally identified as a virulence factor in C. fulvum, since disruption reduces virulence of the fungus on tomato plants. We have recently determined that Ecp2 is a member of a novel, widely distributed and highly diversified within the fungal kingdom multigene superfamily, which we have designated Hce2, for Homologs of C. fulvum Ecp2 effector. Although Ecp2 is present in most organisms as a small secreted protein, the mature part of this protein can be found fused to other protein domains, including the fungal Glycoside Hydrolase family 18, Glyco_hydro_18 Pfam:PF00704 and other, unknown, protein domains. The intrinsic function of Ecp2 remains unknown but it is postulated by   that it is a necrosis-inducing factor in plants that serves pathogenicity on the host.. 
+PF14857 TMEM151 family<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 338 and 558 amino acids in length.. 
+PF14858 Domain of unknown function (DUF4486)<br>This domain family is found in eukaryotes, and is typically between 542 and 565 amino acids in length.. 
+PF14859 Colicin M<br>Colicin M is a toxin produced by, and active against, Escherichia coli. It catalyses the hydrolysis of lipid I and lipid II peptidoglycan intermediates, therefore inhibiting peptidoglycan biosynthesis and leading to lysis of the bacterial cells  .. 
+PF14860 DrrA phosphatidylinositol 4-phosphate binding domain<br>This domain binds to phosphatidylinositol 4-phosphate. It is found in Legionella pneumophila DrrA, a protein involved in the redirection of endoplasmic reticulum-derived vesicles to the Legionella-containing vacuoles [1,2].. 
+PF14861 Plant antimicrobial peptide<br>This family includes plant antimicrobial peptides [1-2]. They adopt an alpha-helical hairpin fold stabilised by two disulphide bonds  .. 
+PF14862 Big defensin<br>Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure [1,2].. 
+PF14863 Alkyl sulfatase dimerisation<br>This domain is found in alkyl sulfatases such as the Pseudomonas aeruginosa SDS hydrolase (Swiss:Q9I5I9), where it acts as a dimerisation domain  . 
+PF14864 Alkyl sulfatase C-terminal<br>This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates  .. 
+PF14865 Macin<br>The macins are antimicrobial proteins [1-3]. They form a disulphide-stabilised alpha-beta motif  .. 
+PF14866 Potassium channel toxin<br>This family includes scorpion potassium channel toxins [1-2].. 
+PF14867 Lantibiotic alpha<br>Lantibiotics are two-component lanthionine-containing peptide antibiotics active on Gram-positive bacteria [1-2].. 
+PF14868 Domain of unknown function (DUF4487)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.. 
+PF14869 Domain of unknown function (DUF4488)<br>Pfam_7936 (release 26.0). In most members this family covers almost the whole sequence, but a few member-sequences also carry a TonB_C domain, PF03544.. 
+PF14870 PSII_YCF48;<br>Photosynthesis system II assembly factor YCF48. Pfam-B_547 (release 26.0). YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localised within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII  . YCF48 is found predominantly in the thykaloid membrane  . It is a BNR repeat protein.. 
+PF14871 Hypothetical glycosyl hydrolase 6<br>GHL6 is a family of hypothetical glycoside hydrolases.. 
+PF14872 Hypothetical glycoside hydrolase 5<br>GHL5 is a family of hypothetical glycoside hydrolases.. 
+PF14873 N-terminal domain of BNR-repeat neuraminidase<br>Pfam-B_13890 (release 26.0). This domain is usually found at the N-terminus of the BNR-repeat neuraminidase protein family.. 
+PF14874 Flagellar-associated PapD-like<br>Pfam-B_1987 (release 26.0). This domain is a putative PapD periplasmic pilus chaperone protein family.. 
+PF14875 N-term cysteine-rich ER, FAM69<br>The FAM69 family of cysteine-rich type II transmembrane proteins localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases  . It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished).. 
+PF14876 RSF1P;<br>Respiratory growth transcriptional regulator. Pfam-B_36578 (release 26.0). This is a family of transcriptional regulators that determine the transition from fermentative activity to growth on glycerol  .. 
+PF14877 Mitochondrial translation initiation factor<br>Pfam-B_22619 (release 26.0). This is a family of mitochondrial initiation factors IF3.. 
+PF14878 Death-like domain of SPT6<br>Pfam-B_9510 (release 26.0). This DLD domain maintains the characteristic overall topology of death domains, as it consists of a six-helix bundle with three stacked antiparallel helices and an additional helix inserted between the final two helices of the bundle. Although it is unlikely that the Spt6 DLD functions in an apoptotic process in yeast, its prominent location and the observation that it displays the most highly conserved region of the Spt6 surface suggest that it mediates important intermolecular interactions [1,2].. 
+PF14879 Domain of unknown function (DUF4489)<br>Pfam-B_28643 (release 26.0). 
+PF14880 Cytochrome oxidase c assembly<br>Pfam-B_122767 (release 26.0). COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase  . Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14  .. 
+PF14881 Tubulin domain<br>This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Misato from Drosophila and Dml1p from fungi are descendants of an ancestral tubulin-like protein, and exhibit regions with similarity to members of a GTPase family that includes eukaryotic tubulin and prokaryotic FtsZ. Dml1p and Misato have been co-opted into a role in mtDNA inheritance in yeast, and into a cell division-related mechanism in flies, respectively. Dml1p might additionally function in the partitioning of the mitochondrial organelle itself, or in the segregation of chromosomes, thereby explaining its essential requirement. This domain subject to extensive post-translational modifications.. 
+PF14882 Hypothetical glycosyl hydrolase 12<br>GHL12 is a family of hypothetical glycoside hydrolases.. 
+PF14883 Hypothetical glycosyl hydrolase family 13<br>GHL13 is a family of hypothetical glycoside hydrolases.. 
+PF14884 Type I membrane glycoproteins cell-cell fusogen<br>Podbilewicz B, Coggill P. Podbilewicz B,  , Pfam-B_25631 (release 26.0). EFF-AFF was first identified when EFF1 mutants were found to block cell fusion in all epidermal and vulval epithelia in the worm  . However, fusion between the anchor cell and the utse syncytium that establishes a continuous uterine-vulval tube proceeds normally in eff-1 mutants and thus Aff1 was established as necessary for this and the fusion of heterologous cells in C. elegans  . The transmembrane forms of FF proteins, like most viral fusogens, possess an N-terminal signal sequence followed by a long extracellular portion, a predicted transmembrane domain, and a short intracellular tail. A striking conservation in the position and number of all 16 cysteines in the extracellular portion of FF proteins from different nematode species suggests that these proteins are folded in a similar 3D structure that is essential for their fusogenic activity  . C. elegans AFF-1 and EFF-1 proteins are essential for developmental cell-to-cell fusion and can merge insect cells. Thus FFs comprise an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle  .. 
+PF14885 Hypothetical glycosyl hydrolase family 15<br>GHL15 is a family of hypothetical glycoside hydrolases.. 
+PF14886 FAM183A and FAM183B related<br>The function of this family of metazoan sequences is not known.. 
+PF14887 HMG (high mobility group) box 5<br>Nucleolar transcription factor/upstream binding factor contains six HMG box domains. This is the fifth HMG box domain in these proteins. This domain has lost DNA-binding ability  .. 
+PF14888 Penicillin-binding protein Tp47 domain C<br>Domain C is the largest domain in this unusual penicillin-binding protein PBP), Tp47. This domain is mainly characterised by an immunoglobulin fold with two opposing beta-sheets that form the typical barrel-like structure. In contrast to the classical immunoglobulin fold, however, this has an additional beta-strand inserted after strand 3. Also, the strands are connected by rather large loops. Helices are inserted between strands 2 and 3 and between strands 4 and 5. Domain C interacts with domain B via a surface that has a slightly concave, goblet-like shape. Tp47 is unusual in that it displays β-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP  .. 
+PF14889 Penicillin-binding protein Tp47 domain a<br>This is the first domain in this unusual penicillin-binding protein PBP), Tp47 is mainly composed of beta-strands and is sequentially non-contiguous. The first three domains in Tp47 interact with each other through intimate domain-domain interfaces. Domain A contacts domain B through its N-terminal segment. Domain A also interacts tightly with domain C, Tp47 is unusual in that it displays β-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP  . . 
+PF14890 Intein splicing domain<br>Inteins are segments of protein which excise themselves from a precursor protein and mediate the rejoining of the remainder of the precursor (the extein). Most inteins consist of a splicing domain which is split into two segments by a homing endonuclease domain. This domain represents the splicing domain  .. 
+PF14891 Effector protein<br>This family of proteins contains an HEXXH motif, typical of zinc metallopeptidases. The family includes the E. coli effector protein NleD, which cleaves and inactivates c-Jun N-terminal kinase (JNK)  .. 
+PF14892 Domain of unknown function (DUF4490)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 101 and 220 amino acids in length. In mice, a member of this family whose expression is induced by p53 may play a role in DNA damage response  .. 
+PF14893 PNMA<br>The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders [1,2]. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis  .. 
+PF14894 Lsm C-terminal<br>This domain is found at the C-terminus of archaeal Lsm (like-Sm) proteins  .. 
+PF14895 Protein phosphatase 1 inhibitor<br>This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes  .. 
+PF14896 EmbC C-terminal domain<br>Pfam-B_4670 (release 7.5). Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the   macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol  . This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate  .. 
+PF14897 EpsG family<br>This family of proteins are related to the EpsG protein from B. subtilis Swiss:P71056. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.. 
+PF14898 Domain of unknown function (DUF4491)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.. 
+PF14899 Domain of unknown function (DUF4492)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. The function of these proteins is unknown.. 
+PF14900 Domain of unknown function (DUF4493)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 264 and 710 amino acids in length. Many of these proteins have a lipid attachment site suggesting they are lipoproteins.. 
+PF14901 Cleavage inducing molecular chaperone<br>Coggill P, Hetherington K. Pfam-B_1192 (release 26.0). Jiv90 is a fragment of the DnaJ protein in eukaryotes and in J-domain protein interacting with viral protein (Jiv) located in the N terminal region of the pestivirus viral polypeptide.  The viral protein interacts stably with non structural (NS) protein NS2, causing a conformational change in NS2-NS3 and stimulates NS2-NS3 cleavage in trans. Cleavage of NS2-NS3 increases cytopathogenicity and consequently aids viral replication. Jiv therefore acts as a regulating cofactor for NS2 auto-protease. The efficient release of NS3 from the viral polypeptide by Jiv is considered crucial to the pestivirus cytopathogenicity  . In eukaryotes, it usually lies 40 residues downstream of DnaJ family Pfam:PF00226. However, the function in eukaryotes is still unknown.. 
+PF14902 Domain of unknown function (DUF4494)<br>This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 172 amino acids in length. There are two conserved sequence motifs: VDA and EAE. There is a single completely conserved residue E that may be functionally important.. 
+PF14903 WG containing repeat<br>
+PF14904 Family of unknown function<br>Coggill P, Hetherington K. Function of this protein family is not known.. 
+PF14905 Outer membrane protein beta-barrel family<br>This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.. 
+PF14906 Domain of unknown function (DUF4495)<br>This domain family is found in eukaryotes, and is typically between 322 and 336 amino acids in length. There are two conserved sequence motifs: QMW and DLW. Proteins in this family vary in length from 793 to 1184 amino acids.. 
+PF14907 Uncharacterised nucleotidyltransferase<br>This family is likely to be an uncharacterised group of nucleotidyltransferases.. 
+PF14908 Domain of unknown function (DUF4496)<br>This domain family is found in eukaryotes, and is typically between 134 and 154 amino acids in length. Proteins in this family vary in length between 264 and 772 amino acid residues.. 
+PF14909 Spermatogenesis-assoc protein 6<br>This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family has similarity to the motor domain of kinesin related proteins and with the Caenorhabditis elegans neural calcium sensor protein (NCS�2).. 
+PF14910 S-phase genomic integrity recombination mediator, N-terminal<br>MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication.  MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse  . Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants [2,3]. This family is the more N-terminal region of the proteins.. 
+PF14911 S-phase genomic integrity recombination mediator, C-terminal<br>MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication.  MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse  . Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants [2,3]. This family is the more C-terminal region of the proteins.. 
+PF14912 Testicular haploid expressed repeat<br>This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions [1,2].  Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice  .. 
+PF14913 DPCD protein family<br>Coggill P, Hetherington K. This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD)  . This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants  .. 
+PF14914 LRRC37A/B like protein 1 C-terminal domain<br>Coggill P, Hetherington K. This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1)  . The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation  .. 
+PF14915 CCDC144C protein coiled-coil region<br>Coggill P, Hetherington K. This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.. 
+PF14916 Coiled-coil domain of unknown function<br>This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.. 
+PF14917 Coiled coil protein 74, C terminal<br>Pfam-B_23141 (release 26.0). This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer [].. 
+PF14918 MDM2-binding<br>MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle  . MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner  . MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells  . MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4)  . It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920. . 
+PF14919 MDM2-binding<br>MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle  . MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner  . MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells  . MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4)  . It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14920.. 
+PF14920 MDM2-binding<br>MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle  . MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner  . MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells  . MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4)  . It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14919.. 
+PF14921 Adenomatosis polyposis coli down-regulated 1<br>The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo  . APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region.  The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling  .. 
+PF14922 Protein of unknown function<br>This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.. 
+PF14923 Coiled-coil protein 142<br>The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.. 
+PF14924 Protein of unknown function (DUF4497)<br>This domain family is found in eukaryotes, and is typically between 107 and 123 amino acids in length. There are two completely conserved G residues that may be functionally important.. 
+PF14925 Domain of unknown function<br>Members of this family carry two distinct, highly conserved sequence motifs, CPPPLYYTHL and HPHLAWLY. The family is found in eukaryotes, and the function is not known. This family lies at the C-terminus of members.. 
+PF14926 Domain of unknown function (DUF4498)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 308 amino acids in length.. 
+PF14927 Neurensin<br>The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2  . Neurensin-1 plays a role in neurite extension  .. 
+PF14928 Short tail fibre protein receptor-binding domain<br>This domain is a receptor binding domain found on bacteriophage short tail fibre proteins. It contains a zinc-binding site and a potential lipopolysaccharide-binding site  .. 
+PF14929 TAF RNA Polymerase I subunit A<br>Coggill P, Hetherington K. TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilises nucleolar transcription factor 1/UBTF on rDNA.. 
+PF14930 Quinohemoprotein amine dehydrogenase, alpha subunit domain II<br>This is the second domain of the alpha subunit of quinohemoprotein amine dehydrogenase [1,2]. 
+PF14931 Intraflagellar transport complex B, subunit 20<br>IFT20 is subunit 20 of the intraflagellar transport complex B  . The intraflagellar transport complex assembles and maintains eukaryotic cilia and flagella. IFT20 is localised to the Golgi complex and is anchored there by the Golgi polypeptide, GMAP210, whereas all other subunits except IFT172 localise to cilia and the peri-basal body or centrosomal region at the base of cilia [1,2,3].  IFT20 accompanies Golgi-derived vesicles to the point of exocytosis near the basal bodies where the other IFT polypeptides are present, and where the intact IFT particle is assembled in association with the inner surface of the cell membrane.  Passage of the IFT complex then follows, through the flagellar pore recognition site at the transition region, into the ciliary compartment.  There also appears to be a role of intraflagellar transport (IFT) polypeptides in the formation of the immune synapse in non ciliated cells. The flagellum, in addition to being a sensory and motile organelle, is also a secretory organelle  . A number of IFT components are expressed in haematopoietic cells, which have no cilia, indicating an unexpected role of IFT proteins in immune synapse-assembly and intracellular membrane trafficking in T lymphocytes; this suggests that the immune synapse could represent the functional homologue of the primary cilium in these cells [6,7].. 
+PF14932 HAUS augmin-like complex subunit 3<br>This domain is subunit three of the augmin complex found from Drosophila to humans  . The HAUS-augmin complex is made up of eight subunits.\.   The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity  .. 
+PF14933 CEP19-like protein<br>Coggill P, Hetherington K. This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organise the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase  .. 
+PF14934 Domain of unknown function (DUF4499)<br>Coggill P, Hetherington K. This family contains a protein found in eukaryotes. Transmembrane protein C10orf57 is encoded for by the gene chromosome 10 open reading frame 57 (C10orf57) located in chromosomal position 10q22.3. The exact function of this protein is still unknown, however it is thought to be an integral membrane protein. The protein sequence is 123 amino acids in length and has a mass of approximately 14.2 kDa.  The family also includes some longer proteins that possess an N-terminal dehydrogenase domain, Pfam:PF01073.. 
+PF14935 Transmembrane protein 138<br>Coggill P, Hetherington L. This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells  . Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.. 
+PF14936 Tumour protein p53-inducible protein 11<br>Coggill P, Hetherington K. TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis  . The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation  .. 
+PF14937 Domain of unknown function (DUF4500)<br>Coggill P, Hetherington K. This family is found in eukaryotes. The function of this protein remains unknown. The gene which encodes for this protein is named chromosome 6 open reading frame 162 (C6orf162) and is found between the chromosomal positions 6q15-q16.1. It is thought that this protein may be an important part of membrane function.. 
+PF14938 Soluble NSF attachment protein, SNAP<br>The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus  . They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor)  . They are structurally similar to TPR repeats  .. 
+PF14939 ShortName;<br>DDB1-and CUL4-substrate receptor 15, WD repeat. DCAFs, Ddb1- and Cul4-associated factors, are substrate receptors for the Cul4-Ddb1 Ubiquitin Ligase. There are 18 different factors, the majority of which are WD40-repeat-proteins  .. 
+PF14940 Transmembrane 219<br>Coggill P, Hetherington K. This protein belongs to a family found in eukaryotes.  Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention  .. 
+PF14941 Transcriptional regulator, Out at first<br>Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes  . An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response  .. 
+PF14942 Organelle biogenesis, Muted-like protein<br>Coggill P, Hetherington P. The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms.  The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system  .. 
+PF14943 Mitochondrial ribosome subunit S26<br>This family of proteins corresponds to mitochondrial ribosomal subunit S26 in eukaryotes  . 
+PF14944 Tongue Cancer Chemotherapy Resistant Protein 1<br>Coggill P, Hetherington K. This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length  .. 
+PF14945 Normal lung function maintenance, Low in Lung Cancer 1 protein<br>Coggill P, Hetherington K. This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis  .. 
+PF14946 Domain of unknown function (DUF4501)<br>Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 167 and 308 amino acids in length. The exact function of this protein remains unknown, but it is thought to be a single-pass membrane protein. This family contains many highly conserved cysteine residues.. 
+PF14947 Winged helix-turn-helix<br>This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerisation of this domain  .. 
+PF14948 RESP18 domain<br>This domain is found in the glucocorticoid-responsive protein regulated endocrine-specific protein 18 (RESP18) and in the N-terminal extracellular region of receptor-type tyrosine-protein phosphatases containing the protein-tyrosine phosphatase receptor IA-2 domain (Pfam:PF11548) [1,2].. 
+PF14949 ARF7 effector protein C-terminus<br>This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells  . It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.. 
+PF14950 Domain of unknown function (DUF4502)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.. 
+PF14951 Domain of unknown function (DUF4503)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.. 
+PF14952 Putative treble-clef, zinc-finger, Zn-binding<br>This domain resembles the zinc-binding domain of prokaryotic topoisomerases, family DNA_ligase_ZBD Pfam:PF03119. The function of the eukaryotic proteins it is carried on is not known.. 
+PF14953 Domain of unknown function (DUF4504)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.. 
+PF14954 Limb expression 1<br>This entry represents the limb expression 1 (LIX1) family  .. 
+PF14955 Mitochondrial ribosome subunit S24<br>This family of proteins corresponds to mitochondrial ribosomal subunit S24 in eukaryotes [1-2].. 
+PF14956 Domain of unknown function (DUF4505)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 166 and 225 amino acids in length.. 
+PF14957 Cdc42 effector<br>The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton  . They may function as negative regulators of Rho GTPase signaling  .. 
+PF14958 Domain of unknown function (DUF4506)<br>This domain family is found in eukaryotes, and is approximately 140 amino acids in length.. 
+PF14959 gamma-Secretase-activating protein C-term<br>GSAP, or gamma-secretase-activating protein, also known as PION, regulates gamma-secretase activity. The holo-protein is a large, approx 850 residue protein that is rapidly cleaved to an active 16 kDa C-terminal fragment that is the stable, predominant form. GSAP is expressed in inclusion bodies and is important in brain function. It dramatically and selectively increases neurotoxic beta-Amyloid production in the brain through a mechanism involving its interactions with both gamma-secretase and its substrate, the amyloid precursor protein C-terminal fragment (APP-CTF). Accumulation of neurotoxic beta-Amyloid is a major hallmark of Alzheimer's disease.  Formation of beta-Amyloid is catalysed by gamma-secretase, a protease with numerous substrates that catalyses the intra-membrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein)  .  The secondary structure of GSAP is largely alpha-helical, lacking well-defined tertiary structure. GSAP represents a type of gamma-secretase regulator that directs enzyme specificity by interacting with a specific substrate  .. 
+PF14960 ATP synthase regulation<br>Members of this family are subunits of mitochondrial ATP synthase (F-ATPase) [1-2] and vacuolar ATPase (V-ATPase)  . In F-ATPase, this subunit regulates mitochondrial ATP synthase population  .. 
+PF14961 Broad-minded protein<br>Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth  .. 
+PF14962 Mitochondria Localisation Sequence<br>Coggill P, Hetherington K. This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with Pfam:PF07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor  . The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.. 
+PF14963 Calcium signal-modulating cyclophilin ligand<br>Calcium signal-modulating cyclophilin ligand was originally identified in a screen for cyclophilin B-interacting proteins. It is likely to be involved in calcium signalling  . It has also been shown to interact with many other signalling molecules including proto-oncogene tyrosine-protein kinase LCK, tumor necrosis factor receptor superfamily member 13B and EGFR [2-4].. 
+PF14964 Domain of unknown function (DUF4507)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 434 amino acids in length.. 
+PF14965 Negative regulator of p53/TP53<br>Coggill P, Hetherington K. This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours  .. 
+PF14966 DNA repair REX1-B<br>This family of proteins includes Chlamydomonas reinhardtii REX1-B (Required for Excision 1-B) which is involved in a light-independent DNA repair pathway  .. 
+PF14967 FAM70 protein<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 241 and 349 amino acids in length. The function of this family is unknown.. 
+PF14968 Coiled coil protein 84<br>The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.. 
+PF14969 Domain of unknown function (DUF4508)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 253 amino acids in length.. 
+PF14970 Domain of unknown function (DUF4509)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 212 and 449 amino acids in length. There is a conserved WLL sequence motif.. 
+PF14971 Domain of unknown function (DUF4510)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 242 and 452 amino acids in length. There are two conserved sequence motifs: LEA and WMD.. 
+PF14972 Mitochondrial morphogenesis regulator<br>This family of proteins regulate mitochondrial morphogenesis via a mechanism which is independent of mitofusins and dynamin-related protein 1  .. 
+PF14973 TERF1-interacting nuclear factor 2 N-terminus<br>This is the N-terminus of TERF1-interacting nuclear factor 2. It is required for the formation of the shelterin complex. The shelterin complex is involved in the protection and maintenance of telomeres [1-3].. 
+PF14974 Domain of unknown function (DUF4511)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 116 and 127 amino acids in length.. 
+PF14975 Domain of unknown function (DUF4512)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 74 and 104 amino acids in length. There are two completely conserved residues (C and P) that may be functionally important.. 
+PF14976 FAM72 protein<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.. 
+PF14977 FAM194 protein<br>This family is found in eukaryotes, and is approximately 210 amino acids in length. There is a conserved YPSG sequence motif. The function of this family is unknown.. 
+PF14978 Mitochondrial ribosome protein 63<br>This family of proteins is present in the intact 55S subunit of the mitochondrial ribosome. It is not known if it belongs to the 28S or to the 39S subunit  .. 
+PF14979 Transmembrane 52<br>This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 160 and 236 amino acids in length. There is a conserved LLCG sequence motif. The function of this family is unknown.. 
+PF14980 TIP39 peptide<br>
+PF14981 FAM165 family<br>This family of proteins known as FAM165 are found in eukaryotes. Members of this family are as yet uncharacterised. Proteins in this family are typically short membrane proteins between 55 and 70 amino acids in length.. 
+PF14982 UPF0731 family<br>The UPF0731 family of uncharacterised proteins is found in mammals.. 
+PF14983 Domain of unknown function (DUF4513)<br>This family of uncharacterised proteins is found in chordates.. 
+PF14984 CD24 protein<br>
+PF14985 TM140 protein family<br>This family of uncharacterised membrane proteins are called transmembrane protein 140. They are found in mammals.. 
+PF14986 Domain of unknown function (DUF4514)<br>This family of uncharacterised proteins are found in mammals.. 
+PF14987 NADH dehydrogenase 1 alpha subcomplex subunit 3<br>This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic [1-2].. 
+PF14988 Domain of unknown function (DUF4515)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.. 
+PF14989 Coiled-coil domain containing 32<br>Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 188 amino acids in length. The gene that encodes this protein is C15orf57 but its protein product is called Protein CCDC32 (Coiled-coil domain containing 32). The exact function of this protein is still unknown.. 
+PF14990 Domain of unknown function (DUF4516)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 56 and 69 amino acids in length.. 
+PF14991 Protein melan-A<br>
+PF14992 TMCO5 family<br>The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.. 
+PF14993 Neuropeptide S precursor protein<br>
+PF14994 Testis-specific gene 13 protein<br>This family of uncharacterised proteins are found in chordates. In humans this gene is found to be expressed specifically in the testes.. 
+PF14995 Transmembrane protein<br>Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 138 and 164 amino acids in length. There are two completely conserved residues (H and E) that may be functionally important and four transmembrane helices. The domains in this family vary in length from 124 to 126 amino acids. The precise function of the protein family is still unknown.. 
+PF14996 Retinal Maintenance<br>Coggill P, Hetherington K. RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively  .. 
+PF14997 CECR6/TMEM121 family<br>This family includes Cat eye syndrome critical region protein 6, a protein which has been identified in a screen for candidate genes for the developmental disorder Cat Eye Syndrome (CES)  . It also includes the TMEM121 transmembrane proteins. The function of this family is unknown.. 
+PF14998 Transcription Regulator<br>Coggill P, Hetherington K. The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4  . This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins  . Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog  .  This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.. 
+PF14999 Shadow of prion protein, neuroprotective<br>Coggill P, Hetherington K. This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases  . This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.. 
+PF15000 Tumour suppressor candidate 2<br>This family of proteins are candidate tumour suppressors [1-2].. 
+PF15001 AP-5 complex subunit sigma-1<br>This family of proteins are subunits of the adaptor protein complex AP-5  .. 
+PF15002 ERK and JNK pathways, inhibitor<br>Coggill P, Hetherington K. This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38.  CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival  . Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerisation.. 
+PF15003 HAUS augmin-like complex subunit 2 <br>Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organising centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis  .  This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis  . This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.. 
+PF15004 Myeloma-overexpressed-like<br>This family of proteins is found in eukaryotes. It includes human myeloma-overexpressed gene 2 protein. Proteins in this family are typically between 45 and 74 amino acids in length. There are two conserved sequence motifs: MKP and DEMF. The function of this family is unknown.. 
+PF15005 Izumo sperm-egg fusion<br>Coggill P, Hetherington K. Izumo is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization  .  There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204)  . There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific [1,2]. This family of proteins is found in eukaryotes and are typically between 193 and 305 amino acids in length.. 
+PF15006 Domain of unknown function (DUF4517)<br>Coggill P, Hetherington K. The function of this protein remains unknown. This family of proteins is found in eukaryotes and are typically between 160 and 182 amino acids in length.. 
+PF15007 Centrosomal spindle body, CEP44<br>Coggill P, Hetherington K. CEP44 is a coiled coil domain found localised in the centrosome and spindle poles.. 
+PF15008 Domain of unknown function (DUF4518)<br>Coggill P, Hetherington K. The precise function of this protein family is unknown but it is thought to be involved in apoptosis regulation.. 
+PF15009 Transmembrane protein 173<br>Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA [1-4].. 
+PF15010 Putative cell signalling<br>Coggill P, Hetherington K. The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways  . This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.. 
+PF15011 Casein Kinase 2 substrate<br>Coggill P, Hetherington K. It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterised. It is found to be localised in the nucleus and cytoplasm  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.. 
+PF15012 Domain of unknown function (DUF4519)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between  and 59 amino acids in length. There are two conserved sequence motifs: KET and VLP. There is a single completely conserved residue P that may be functionally important.. 
+PF15013 CCSMST1 family<br>This family of proteins was discovered in a screen of Bos taurus placental ESTs. The B. taurus member of this family was named cattle cerebrum and skeletal muscle-specific transcript 1  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 97 and 157 amino acids in length. There is a single completely conserved residue D that may be functionally important. The function of this family is unknown.. 
+PF15014 Ceroid-lipofuscinosis neuronal protein 5<br>
+PF15015 Spermatogenesis-associated, N-terminal<br>NYD-SP12, also known as SPATA16, is a germ-cell specific participant in the Golgi apparatus, and its expression is confined to spermatogenic epithelium, not being found in interstitial cells  . Computer analysis of the protein-sequence showed that NYD-SP12 contains a cluster of phosphorylation sites for protein kinase C as well as for cyclic nucleotide-dependent protein kinases [2,3]. It is postulated that since the mutation of some Golgi apparatus’ proteins are responsible for male infertility that NYD-SP12 might play a role in modification and sorting of acrosomal enzymes  . OMIM:102530.. 
+PF15016 Domain of unknown function (DUF4520)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.. 
+PF15017 Drug resistance and apoptosis regulator<br>Coggill P, Hetherington K. AF1q is an oncogenic factor involved in leukaemia development, thyroid tumourigenesis, and breast cancer metastasis. AF1q plays a critical role in the regulation of apoptosis and drug resistance. Initially identified as a mixed-lineage leukaemia fusion partner (MLL11) in infant acute myelomonocytic leukemia carrying t(1;11)(q21;q23) translocation. It is located in chromosome 1 band 21  . AF1Q may be a novel mediator of metastasis promotion in human breast cancer through regulation of the MMP pathway and RhoC expression  .This family of proteins is found in eukaryotes. Proteins in this family are typically between 25 and 482 amino acids in length.. 
+PF15018 TRP-interacting helix<br>Coggill P, Hetherington K. This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron  .  InaF is a protein required for TRP calcium channel function in Drosophila [2,3]. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types  .  The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.. 
+PF15019 FTDALS;<br>C9orf72-like protein family. Coggill P, Hetherington K. The precise function of this family is unknown but members have been found to be localised in the cytoplasm of brain tissue. Defects in the gene, C9orf72, are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexa-nucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci  . This domain family is found in eukaryotes, and is typically between 230 and 250 amino acids in length. There is a single completely conserved residue F that may be functionally important.. 
+PF15020 Cation channel sperm-associated protein subunit delta<br>The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport  .. 
+PF15021 Protein of unknown function (DUF4521)<br>This family of vertebrate proteins is functionally uncharacterised. The family includes the Chromosome 20 protein C20orf196.. 
+PF15022 Protein of unknown function (DUF4522)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. In human this protein is known as C4orf36.. 
+PF15023 Protein of unknown function (DUF4523)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in mammals.. 
+PF15024 Glycosyltransferase family 18<br>Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme  .. 
+PF15025 Domain of unknown function (DUF4524)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.. 
+PF15026 FAM74 protein<br>This family of uncharacterised proteins are found in humans and are known as FAM74 proteins. Members of this family contain several short protein repeats.. 
+PF15027 Domain of unknown function (DUF4525)<br>This domain is found in eukaryotes. It is often found at the N-terminus of glycosyltransferase family 18 enzymes (Pfam:PF15024). It is also found in coiled-coil domain-containing protein 126.. 
+PF15028 Pre-T-cell antigen receptor<br>The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation  . This protein contains an immunoglobulin domain  .. 
+PF15029 Protein of unknown function (DUF4526)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in mammals and includes the human integral membrane protein TMEM174 protein.. 
+PF15030 Protein of unknown function (DUF4527)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates.. 
+PF15031 Domain of unknown function (DUF4528)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 95 and 154 amino acids in length. This family includes Human C15orf61.. 
+PF15032 Protein of unknown function (DUF4529)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.. 
+PF15033 Kinocilin protein<br>This family of kinocilin proteins is found in vertebrate. In mouse it has been shown that this protein is expressed primarily in the kinocilium of sensory cells in the inner ear  .. 
+PF15034 KRTAP type 7 family<br>This family of keratin associated proteins are found in vertebrate.. 
+PF15035 Ciliary rootlet component, centrosome cohesion<br>
+PF15036 Interleukin 34<br>
+PF15037 Interleukin-17 receptor extracellular region<br>This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain  . Human putative interleukin-17 receptor E-like consists only of this domain.. 
+PF15038 Jiraiya<br>Jiraiya inhibits bone morphogenetic protein (BMP) signaling during embryogenesis  . The human member of this family is TMEM221.. 
+PF15039 Domain of unknown function (DUF4530)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically around 140 amino acids in length. The human member of this family is C19orf69.. 
+PF15040 Humanin family<br>This family of proteins is found exclusively in humans. Humanin is a short anti-apoptotic peptide that interacts with Bax  .. 
+PF15041 Domain of unknown function (DUF4531)<br>This family of uncharacterised proteins is found in mammals. This family includes the human protein C19orf71.. 
+PF15042 Late cornified envelope-like proline-rich protein 1<br>This family of uncharacterised proteins is found in mammals.. 
+PF15043 CB1 cannabinoid receptor-interacting protein 1<br>This family of proteins interacts with cannabinoid receptor 1 (CNR1) and attenuates CNR1-mediated tonic inhibition of voltage-gated calcium channels  .. 
+PF15044 Mitochondrial function, CLU-N-term<br>CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organisms.  The function of this domain is not known. It family is found in association with Pfam:PF13236.. 
+PF15045 Clathrin-binding box of Aftiphilin, vesicle trafficking<br>Aftiphilin forms a stable complex with p200 and gamma-synergin. This family contains a clathrin box, with two identified clathrin-binding motifs.  This family of proteins is found in eukaryotes.. 
+PF15046 Protein of unknown function (DUF4532)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.. 
+PF15047 Protein of unknown function (DUF4533)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. This family includes two human proteins: C12orf60 and C12orf69.. 
+PF15048 Organic solute transporter subunit beta protein<br>
+PF15049 Protein of unknown function (DUF4534)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.. 
+PF15050 SCIMP protein<br>This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling  .. 
+PF15051 FAM198 protein<br>This family of proteins is found in eukaryotes. The function of this family is unknown. Murine FAM198B is downregulated by FGFR signalling  .. 
+PF15052 TMEM169 protein family<br>Coggill P, Hetherington K. This domain is thought to be structured transmembrane helices and includes the intermediary cytoplasmic domain. It is found in eukaryotes, and is approximately 130 amino acids in length.. 
+PF15053 Mjmu-R1-like protein family<br>Coggill P, Hetherington K. This protein family is thought to have a role in spermatogenesis. This family of proteins is found in eukaryotes. In humans, it is found in chromosome 17 open reading frame 75 (C17orf75). Proteins in this family are typically between 217 and 399 amino acids in length.. 
+PF15054 Domain of unknown function (DUF4535)<br>Coggill P, Hetherington K. This family includes the uncharacterised protein C7orf73 that is found in eukaryotes. Members are generally less than 100 residues in length. Although the precise function of the domain is still unknown, members have a predicted N-terminal signal peptide sequence which suggests they are short secreted peptides.. 
+PF15055 Domain of unknown function (DUF4536)<br>Coggill P, Hetherington K. This domain family is thought to be a transmembrane helix. It is found in eukaryotes, and is approximately 50 amino acids in length. In humans, it is located in the chromosomal position, C9orf123.. 
+PF15056 Neuritin protein family<br>Coggill P, Hetherington K. The domain family Neuritin1 (NRN1) is a GPI-anchored protein expressed in post-mitotic-differentiating neurons in the developing nervous system  . NRN1 is a glutamate and neurotrophin receptor target encoding a neuronal protein that functions extracellularly to modulate neurite outgrowth (OMIM:607409).\.   This family of proteins is found in eukaryotes. Proteins in this family are typically between and 158 amino acids in length.. 
+PF15057 Domain of unknown function (DUF4537)<br>The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.. 
+PF15058 Speriolin N terminus<br>This family represents the N-terminus of the sperm centrosome protein speriolin [1-2].. 
+PF15059 Speriolin C-terminus<br>This family represents the C-terminus of the sperm centrosome protein speriolin [1-2].. 
+PF15060 Differentiation and proliferation regulator<br>Coggill P, Hetherington K. Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells  .. 
+PF15061 Domain of unknown function (DUF4538)<br>Coggill P, Hetherington K. This protein family is thought to be a transmembrane helix. Its function remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are typically between 58 and 87 amino acids in length.. 
+PF15062 Haemopoietic lineage transmembrane helix<br>Coggill P, Hetherington K. ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p  .. 
+PF15063 Thyroid cancer protein 1<br>Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma  . This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle  . It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor  . In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.. 
+PF15064 Cation channel sperm-associated protein subunit gamma<br>This family represents the gamma subunit of the CATSPER, or cation channel sperm-associated protein complex. The complex appears only to be expressed in the flagellum of sperm. The complex is activated at alkaline intracellular pH, and being restricted to the flagellum is the mediating calcium channel.. 
+PF15065 Lysosomal transcription factor, NCU-G1<br>NCU-G1 is a set of highly conserved nuclear proteins rich in proline with a molecular weight of approximately 44 kDa. Especially high levels are detected in human prostate, liver and kidney. NCU-G1 is a dual-function family capable of functioning as a transcription factor as well as a nuclear receptor co-activator by stimulating the transcriptional activity of peroxisome proliferator-activated receptor-alpha (PPAR-alpha)  .. 
+PF15066 Cancer-associated gene protein 1 family<br>CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues  .  CAGE-1 is predominantly expressed during post-meiotic stages. It localises to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa  .. 
+PF15067 FAM124 family<br>Coggill P, Hetherington K. The exact function of this protein family remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are approximately 480 amino acids in length. There is a conserved LFL sequence motif.. 
+PF15068 FAM101 family<br>This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilise peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes  .. 
+PF15069 FAM163 family<br>Coggill P, Hetherington K. This protein family is alternatively named Neuroblastoma-derived secretory proteins. Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow  .. 
+PF15070 Putative golgin subfamily A member 2-like protein 5<br>The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.. 
+PF15071 Transmembrane family 220, helix<br>Coggill P, Hetherington K. Transmembrane 220 (TMEM220) is a domain of unknown function. It is thought to be a transmembrane helix. The length of this protein is typically between 150 and 160 amino acids. In humans, it is found in the chromosomal position 17p13.1.. 
+PF15072 Domain of unknown function (DUF4539)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 230 and 625 amino acids in length.. 
+PF15073 Domain of unknown function (DUF4540)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 302 amino acids in length. In humans, it is found in the chromosomal position, C7orf72.. 
+PF15074 Domain of unknown function (DUF4541)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 100 and 163 amino acids in length. There is a conserved KLHRDDR sequence motif. There is a single completely conserved residue Y that may be functionally important. In humans, the gene is found in the chromosomal location, C5orf49.. 
+PF15075 Domain of unknown function (DUF4542)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 123 and 173 amino acids in length. There is a conserved IPPYN sequence motif. The gene that encodes this protein in humans, is found in the chromosomal position, C17orf98.. 
+PF15076 Domain of unknown function (DUF4543)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 90 amino acids in length. The human member of this family is C17orf67.. 
+PF15077 Domain of unknown function (DUF4544)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 118 and 256 amino acids in length. The human member of this family is C11orf85.. 
+PF15078 Domain of unknown function (DUF4545)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 417 amino acids in length. The human member of this family is C1orf141.. 
+PF15079 Domain of unknown function (DUF4546)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 88 and 212 amino acids in length. The human member of this family is C1orf49.. 
+PF15080 Domain of unknown function (DUF4547)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 144 and 206 amino acids in length. The human member of this family is C3orf43.. 
+PF15081 Domain of unknown function (DUF4548)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 178 amino acids in length. The human member of this family is C1orf105.. 
+PF15082 Domain of unknown function (DUF4549)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.. 
+PF15083 Colipase-like<br>Eberhardt RY, Coggill P, Hetherington K. This is a family of colipase-like proteins.. 
+PF15084 Domain of unknown function (DUF4550)<br>This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 100 amino acids in length. This domain contains an N-terminal HXE motif.. 
+PF15085 Neuropeptide FF<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15086 Uncharacterised protein family UPF0542<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved LSWKL sequence motif. This family includes human protein C5orf43.. 
+PF15087 Protein of unknown function (DUF4551)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa. This family includes human protein C12orf56.. 
+PF15088 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15089 Domain of unknown function (DUF4552)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. Proteins in this family are typically between 425 and 649 amino acids in length.. 
+PF15090 Domain of unknown function (DUF4553)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. This family includes the human protein C10orf12.. 
+PF15091 Domain of unknown function (DUF4554)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.. 
+PF15092 Uncharacterised protein family UPF0728<br>This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa. There is a conserved GPY sequence motif.. 
+PF15093 Domain of unknown function (DUF4555)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa.This family includes the human protein C7orf31.. 
+PF15094 Domain of unknown function (DUF4556)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. This family includes human protein C1orf127.. 
+PF15095 Interleukin 33<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15096 G6B family<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15097 Immunoglobulin J chain<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15098 TMEM89 protein family<br>The function of this family of transmembrane proteins, TMEM89, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are approximately 159 amino acids in length.. 
+PF15099 Phosphoinositide-interacting protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane  . Proteins in this family are approximately 140 amino acids in length.. 
+PF15100 TMEM187 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family, TMEM187, is not known, however it is predicted to be a multi-pass membrane protein. Members of this family are as yet uncharacterised. This protein family is also alternatively named ITBA1. This family of proteins are found in eukaryotes. Proteins in this family are typically between 239 and 267 amino acids in length.. 
+PF15101 Domain of unknown function (DUF4557)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved TVF sequence motif.. 
+PF15102 TMEM154 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins has not, as yet, been determined. However, it is thought to be a therapeutic target for ovine lentivirus infection  . This family of proteins is found in eukaryotes and members are typically between 138 and 320 amino acids in length.. 
+PF15103 G0/G1 switch protein 2<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers  .. 
+PF15104 Domain of unknown function (DUF4558)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 78 and 121 amino acids in length. One member is annotated as being a flagellar associated protein.. 
+PF15105 TMEM61 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 150 and 211 amino acids in length.. 
+PF15106 TMEM156 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, TMEM 156, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins are found in eukaryotes. Proteins in this family are approximately 310 amino acids in length. In humans, the gene encoding this protein is located in the chromosomal position, 4p14.. 
+PF15107 FAM216B protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of proteins, FAM216B, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins are found in eukaryotes. Proteins in this family are approximately 150 amino acids in length. In humans, the gene encoding this protein is located in the position, C13orf30.. 
+PF15108 Voltage-dependent calcium channel gamma-like subunit protein family<br>Eberhardt RY, Coggill P, Hetherington K. This family of transmembrane proteins, TMEM37, has a role in stabilising the calcium channel in an inactivated (closed) state. It is a subunit of the L-type calcium channels. This family of proteins are found in eukaryotes. Proteins in this family are approximately 210 amino acids in length.. 
+PF15109 TMEM125 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, TMEM125, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 55 and 232 amino acids in length.. 
+PF15110 TMEM141 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, TMEM141, has not, as yet, been determined. Members of this family remain uncharacterised. TMEM141 protein family is found in eukaryotes. Proteins in this family are typically between 103 and 124 amino acids in length. There are two completely conserved residues (C and W) that may be functionally important.. 
+PF15111 TMEM101 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, TMEM101, has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 257 amino acids in length.. 
+PF15112 Domain of unknown function (DUF4559)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes human protein CXorf38.. 
+PF15113 TMEM117 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 504 amino acids in length.. 
+PF15114 Uncharacterised protein family UPF0640<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 70 and 80 amino acids in length. There are two conserved sequence motifs: PGK and YRFLP.. 
+PF15115 Domain of unknown function with conserved HDNR motif<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 219 amino acids in length. There is a conserved HDNR sequence motif. The function is not known.. 
+PF15116 CAMPATH-1 antigen<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15117 Uncharacterised protein family UPF0697   <br>This family of uncharacterised proteins is found in vertebrates. Proteins in this family are typically around 100 amino acids in length.. 
+PF15118 Domain of unknown function (DUF4560)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 66 and 78 amino acids in length. There are two conserved sequence motifs: FCK and RTL.. 
+PF15119 Apolipoprotein C4<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15120 Domain of unknown function (DUF4561)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.. 
+PF15121 TMEM71 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family, TMEM71, is not known, however it is predicted to be a transmembrane protein. This family of proteins is found in eukaryotes and located in the cell membrane. Proteins in this family vary between 41 and 291 amino acids in length.. 
+PF15122 TMEM206 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, TMEM206, has not, as yet, been determined. Members of this family are remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are approximately 350 amino acids in length.. 
+PF15123 Domain of unknown function (DUF4562)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved HRYQNPW sequence motif. This family includes the human protein C4orf45.. 
+PF15124 Domain of unknown function (DUF4563)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes the human protein C3orf24.. 
+PF15125 TMEM238 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, TMEM238; has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 61 and 153 amino acids in length.. 
+PF15127 Protein of unknown function (DUF4565)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  This family includes the human protein C2orf88.. 
+PF15128 T-cell leukemia translocation-altered<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is required for osteoclastogenesis  .. 
+PF15129 FAM150 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins known as FAM150 is found in eukaryotes. Members of this family are as yet uncharacterised. Proteins in this family are approximately 143 amino acids in length. The function of this family has not, as yet, been determined, however it is predicted to be a secretory protein family.. 
+PF15130 Domain of unknown function (DUF4566)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes human protein C6orf62.. 
+PF15131 Domain of unknown function (DUF4567)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in some mammals.. 
+PF15132 Domain of unknown function (DUF4568)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.. 
+PF15133 Domain of unknown function (DUF4569)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  This family includes human protein CXorf21.. 
+PF15134 Domain of unknown function (DUF4570)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. . 
+PF15135 Uncharacterised protein UPF0515<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There are two conserved sequence motifs: PLT and HSC.. 
+PF15136 Uncharacterised protein family UPF0449<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There is a conserved LPTRP sequence motif.. 
+PF15137 Domain of unknown function (DUF4571)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrate. This family includes human protein C21orf62.. 
+PF15138 Syncollin<br>Eberhardt RY, Coggill P, Hetherington K. This family has a role in zymogen granule exocytosis [1-2].. 
+PF15139 Domain of unknown function (DUF4572)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 220 amino acids in length.. 
+PF15140 Domain of unknown function (DUF4573)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.. 
+PF15141 Domain of unknown function (DUF4574)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between  and 86 amino acids in length.. 
+PF15142 INCA1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins inhibits cyclin-dependent kinase activity [1-2].. 
+PF15143 Domain of unknown function (DUF4575)<br>This family of uncharacterised proteins is found in eukaryotes.. 
+PF15144 Domain of unknown function (DUF4576)<br>This family of uncharacterised proteins is found in eukaryotes.. 
+PF15145 Domain of unknown function (DUF4577)<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.. 
+PF15146 Fanconi anemia-associated <br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins plays a role in the Fanconi anemia-associated DNA damage response  .. 
+PF15147 Domain of unknown function (DUF4578)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 137 amino acids in length.. 
+PF15148 Apolipoprotein F<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15149 Cation channel sperm-associated protein subunit beta protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of transmembrane proteins, CATSPERB, has not, as yet, been determined. However, it is thought to play a role in sperm hyperactivation by associating with CATSPER1  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 220 and 1107 amino acids in length.. 
+PF15150 Phorbol-12-myristate-13-acetate-induced<br>Eberhardt RY, Coggill P, Hetherington K. This family carries a BH3 domain between residues 23 and 40.. 
+PF15151 Response gene to complement 32 protein family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 130 amino acids in length. There is a conserved KLGDT sequence motif.. 
+PF15152 Kisspeptin<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15153 Cytokine-like protein 1<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of proteins, CYTL1, has not, as yet, been determined. However it is thought to be a secretory protein expressed in CD34+ haemopoietic cells  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 145 amino acids in length. There are two conserved sequence motifs: PPTCYSR and DDC.. 
+PF15155 MORF4 family-associated protein1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 127 amino acids in length.. 
+PF15156 Ceroid-lipofuscinosis neuronal protein 6<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 190 and 310 amino acids in length.. 
+PF15157 IQ-like<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins includes Human IQ domain-containing protein J (IQCJ).. 
+PF15158 Domain of unknown function (DUF4579)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 192 and 239 amino acids in length. The human member of this family is C8orfK29.. 
+PF15159 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins represents subunit Y of the GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex. It may regulate activity of the complex by binding the catalytic subunit, PIG-A  .. 
+PF15160 Spermatogenesis-associated serine-rich protein 1<br>Eberhardt RY, Coggill P, Hetherington K. Spermatogenesis-associated serine-rich protein 1 is a serine-rich protein differentially expressed during spermatogenesis  .. 
+PF15161 Neuropeptide-like<br>Eberhardt RY, Coggill P, Hetherington K. This family contains putative neuropeptides  .. 
+PF15162 Domain of unknown function (DUF4580)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 63 and 185 amino acids in length.. 
+PF15163 Meiosis-expressed<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is essential for spermiogenesis  .. 
+PF15164 Williams-Beuren syndrome chromosomal region 28 protein homologue<br>WBS28 is an integral membrane family. These proteins have been identified as being linked to Williams-Beuren syndrome, OMIM:194050.  This family of proteins is found in eukaryotes, and are typically 266 amino acids in length.. 
+PF15165 Meiotic recombination protein REC114-like<br>Eberhardt RY, Coggill P, Hetherington K. REC114-like members are necessary for meiotic DNA double-strand break formation. It functions in conjunction with Mei4. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 259 amino acids in length.. 
+PF15167 Domain of unknown function (DUF4581)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically 131 amino acids in length.. 
+PF15168 Triple QxxK/R motif-containing protein family<br>Eberhardt RY, Coggill P, Hetherington K. TRIQK member-proteins share a characteristic triple repeat of the sequence QXXK/R, as well as a hydrophobic C-terminal region. Xenopus and mouse triqk genes are broadly expressed throughout embryogenesis, and mtriqk is also generally expressed in mouse adult tissues. TRIQK proteins are localized to the endoplasmic reticulum membrane.  This family is found in eukaryotes and members are typically between and 86 amino acids in length.. 
+PF15169 Domain of unknown function (DUF4564)<br>This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes the human protein C17orf62.. 
+PF15170 Calcium/calmodulin-dependent protein kinase II inhibitor<br>Eberhardt RY, Coggill P, Hetherington K. CaM-KIIN is the inhibitor of Calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII plays a central part in long-term potentiation, which underlies some forms of learning and memory. CaM-KIIN is a natural, specific inhibitor of CaMKII  . This family is found in eukaryotes.. 
+PF15171 Neuropeptide secretory protein family, NPQ, spexin<br>Eberhardt RY, Coggill P, Hetherington K. Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors  . Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance  .. 
+PF15172 Prolactin-releasing peptide<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15173 FAM180 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 182 amino acids in length. There are two conserved sequence motifs: ELAS and DFE. The function of this family is unknown.. 
+PF15174 Prion-related protein testis-specific<br>Eberhardt RY, Coggill P, Hetherington K. PRNT is a family of prion-related proteins expressed in the testis [1,2].  This family of proteins is found in eukaryotes. Proteins in this family are typically between 52 and 94 amino acids in length.. 
+PF15175 Spermatogenesis-associated protein 24<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins bind to DNA and to TBP (TATA box binding protein), TATA-binding protein (TBP)-related protein 2 (TRF2) and several polycomb factors. It is likely to function as a transcription regulator [1-2].. 
+PF15176 Leucine-rich repeat family 19 TM domain<br>Eberhardt RY, Coggill P, Hetherington K. LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity  . This family of proteins is found in eukaryotes.. 
+PF15177 Interleukin-28A<br>Eberhardt RY, Coggill P, Hetherington K. The protein family, Interleukin-28A, plays an important role in modulating the immune system. This protein family is induced by viral infection and interacts with a class II receptor  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 195 amino acids in length.. 
+PF15178 Mitochondrial import receptor subunit TOM5 homolog<br>Eberhardt RY, Coggill P, Hetherington K. This is a family of transmembrane proteins thought to form part of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex)  . This family of proteins is found in eukaryotes. Proteins in this family are approximately 50 amino acids in length.. 
+PF15179 Myc target protein 1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is regulated by the c-Myc oncoprotein. It regulates the expression of several other c-Myc target genes  .. 
+PF15180 Neuropeptides B and W<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes [1,2].. 
+PF15181 Spermatid-specific manchette-related protein 1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins, SMRP1, is thought to have a role in spermatogenesis and may be involved in differentiation or function of ciliated cells  . This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 260 amino acids in length.. 
+PF15182 Otospiralin<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins, Otospiralin, has a role in maintaining the neurosensory epithelium of the inner ear [1,2]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 90 amino acids in length.. 
+PF15183 Melanocortin-2 receptor accessory protein family<br>Eberhardt RY, Coggill P, Hetherington K. This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.. 
+PF15184 Mitochondrial import receptor subunit TOM6 homolog<br>Eberhardt RY, Coggill P, Hetherington K. TOMM6 forms part of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex)  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 74 amino acids in length.. 
+PF15185 Bcl-2-modifying factor, apoptosis<br>Eberhardt RY, Coggill P, Hetherington K. BMF is thought to play a role in inducing apoptosis.  It is thought to bind to Bcl-2 proteins  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.. 
+PF15186 Testis-expressed sequence 13 protein family<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of proteins has not, as yet, been determined. However, members are thought to be encoded for by spermatogonially-expressed, germ-cell-specific genes  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 177 and 384 amino acids in length. There are two conserved sequence motifs: FIN and LAL.. 
+PF15187 Oesophageal cancer-related gene 4<br>Eberhardt RY, Coggill P, Hetherington K. Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterised by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation  . Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF  . This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.. 
+PF15188 Coiled-coil domain-containing protein 167<br>Eberhardt RY, Coggill P, Hetherington K. The function of this family of coiled-coil domains, has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 103 amino acids in length.. 
+PF15189 Domain of unknown function (DUF4582)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 126 and 788 amino acids in length. In humans, it is encoded for on the chromosomal position, C17orf104.. 
+PF15190 Domain of unknown function (DUF4583)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins, also known as UPF0694, is found in eukaryotes. Proteins in this family are around 135 amino acids in length. In humans, it is found on the chromosomal position, C14orf109.. 
+PF15191 Synaptonemal complex central element protein 3<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15192 TMEM213 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 154 amino acids in length. The function of this family is unknown.. 
+PF15193 FAM24 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 101 amino acids in length. There are two conserved sequence motifs: FDLRT and CLY. The function of this family is unknown.. 
+PF15194 TMEM191C family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 302 amino acids in length. There are two conserved sequence motifs: QDC and RLF. The function of this family is unknown.. 
+PF15195 TMEM210 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 149 amino acids in length. The function of this family is unknown.. 
+PF15196 Activator of apoptosis harakiri<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15197 Leukemia-associated protein 2<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15198 Dexamethasone-induced<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15199 D-amino acid oxidase activator<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15200 Keratinocyte differentiation-associated<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15201 Progressive rod-cone degeneration<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is involved in vision  .. 
+PF15202 Adipogenin<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is involved in the stimulation of adipocyte differentiation and development  .. 
+PF15203 TMEM95 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length. There is a conserved LGG sequence motif. The function of this family is unknown.. 
+PF15204 Kita-kyushu lung cancer antigen 1<br>Eberhardt RY, Coggill P, Hetherington K. This is a family of cancer antigens  .. 
+PF15205 Placenta-specific protein 9<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins was identified as being enriched in placenta  .. 
+PF15206 FAM209 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 170 amino acids in length. The function of this family is unknown.. 
+PF15207 TMEM240 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 54 and 175 amino acids in length. The function of this family is unknown.. 
+PF15208 Rab15 effector<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins has a role in receptor recycling from the endocytic recycling compartment  .. 
+PF15209 Interleukin 31<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15210 Surfactant-associated protein 2<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15211 VEGF co-regulated chemokine 1<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15212 Spermatogenesis-associated protein 19, mitochondrial<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15213 CMT1A duplicated region transcript 4 protein<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15214 Peroxisomal testis-specific protein 1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is testis-specific  .. 
+PF15215 Follicular dendritic cell secreted peptide<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15216 Thymic stromal lymphopoietin<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15217 TSC21 family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is testis-specific  .. 
+PF15218 Spermatogenesis-associated protein 25<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins may be involved in spermatogenesis  .. 
+PF15219 Testis-expressed 12<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15220 Hypoxia-inducible lipid droplet-associated <br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins stimulate intracellular lipid accumulation, function as autocrine growth factors and enhance cell growth [1-2].. 
+PF15221 Lens epithelial cell protein LEP503<br>Eberhardt RY, Coggill P, Hetherington K. This protein may be involved in lens epithelial cell differentiation [1-2].. 
+PF15222 Kidney androgen-regulated <br>Eberhardt RY, Coggill P, Hetherington K. The function of this family is unknown.. 
+PF15223 Domain of unknown function (DUF4584)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are approximately 835 amino acids in length. The family is found in association with Pfam:PF02437.. 
+PF15224 Scrapie-responsive protein 1<br>Eberhardt RY, Coggill P, Hetherington K. This protein family has an important function in acting against the prion protein, Scrapie [1,2].This family of proteins is found in eukaryotes. Proteins in this family are approximately 98 amino acids in length.. 
+PF15225 Interleukin 32<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15226 HCF-1 beta-propeller-interacting protein family<br>Eberhardt RY, Coggill P, Hetherington K. HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localisation. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus  .. 
+PF15227 zinc finger of C3HC4-type, RING<br>This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development  . This domain is likely to be DNA-binding  . This zinc-finger domain together with the RDM domain, Pfam:PF11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme  .. 
+PF15228 Death-associated protein<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15229 POM121 family<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15230 Serine/arginine repetitive matrix protein C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found near to the C-terminus of Serine/arginine repetitive matrix proteins 3 and 4.. 
+PF15231 Variable charge X/Y family<br>Eberhardt RY, Coggill P, Hetherington K. The variable charge X/Y (VCX/VCY) family of proteins has members on the Human X and Y chromosomes, is expressed in male germ calls and may play a role in spermatogenesis or in sex ratio distortion  .. 
+PF15232 Domain of unknown function (DUF4585)<br>Eberhardt RY, Coggill P, Hetherington K. The function of this protein domain family is yet to be characterised. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs.  This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells  .. 
+PF15233 Synaptonemal complex central element protein 1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins includes synaptonemal complex central element protein 1, a component of the synaptonemal complex involved in meiosis, and synaptonemal complex central element protein 1-like, which may be involved in meiosis [1-2].. 
+PF15234 Linker for activation of T-cells<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15235 G protein-regulated inducer of neurite outgrowth C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This represents the C-terminus of the G protein-regulated inducer of neurite outgrowth proteins  .. 
+PF15236 Coiled-coil domain-containing protein 66<br>Eberhardt RY, Coggill P, Hetherington K. This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure  .. 
+PF15237 PTRF/SDPR family<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway  . PRKCDBP appears to act as an immune potentiator  . PTRF is involved in caveolae formation and function  . SDPR is involved in the targetting of protein kinase Calpha to caveolae  .. 
+PF15238 FAM181<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 426 amino acids in length.. 
+PF15239 Domain of unknown function (DUF4586)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.. 
+PF15240 Proline-rich<br>Eberhardt RY, Coggill P, Hetherington K. This family includes several eukaryotic proline-rich proteins.. 
+PF15241 Cylicin N-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This is the N-terminus of cylicin proteins, which may play a role in spermatid differentiation  .. 
+PF15242 Family of FAM53<br>Eberhardt RY, Coggill P, Hetherington K. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation  . It is known to be highly important in neural tube development  . It is found in eukaryotes and is typically between 303 and 413 amino acids in length.. 
+PF15243 Anaphase-promoting complex subunit 15<br>Eberhardt RY, Coggill P, Hetherington K. This is a component of the anaphase promoting complex/cyclosome  .. 
+PF15244 Hydroxy-steroid dehydrogenase<br>Eberhardt RY, Coggill P, Hetherington K. This family also goes by the name of Spermatogenesis-associated protein 7 or SPAT7. It is an aldo-keto reductase (AKR) human type 3 3-alpha-hydroxy-steroid dehydrogenase (H3-alpha-HSD3, AKR1C2), and it plays a crucial role in the regulation of the intracellular concentrations of testosterone and 5-alpha-dihydrotestosterone (5-alpha-DHT), two steroids directly linked to the aetiology and the progression of many prostate diseases and cancer [1,2]. Mutations in the gene cause Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP), the most common hereditary causes of visual impairment in infants and children  .. 
+PF15245 Transcription cofactor vestigial-like protein 4<br>Eberhardt RY, Coggill P, Hetherington K. These proteins act as transcriptional enhancer factor (TEF-1) cofactors  .. 
+PF15246 Nck-associated protein 5, Peripheral clock protein<br>Eberhardt RY, Coggill P, Hetherington K. NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role  .. 
+PF15247 Histone RNA hairpin-binding protein RNA-binding domain<br>Eberhardt RY, Coggill P, Hetherington K. This family represents the RNA-binding domain of histone RNA hairpin-binding protein  .. 
+PF15248 Domain of unknown function (DUF4587)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.. 
+PF15249 Glioma tumor suppressor candidate region<br>Eberhardt RY, Coggill P, Hetherington K. This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. There is a single completely conserved residue F that may be functionally important. Mutations in the gene for this protein in humans leads to the development of oligodendrogliomas  . There is evidence that these protein interacts with SH3 domains  .. 
+PF15250 Raftlin<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins plays a role in the formation and/or maintenance of lipid rafts  .. 
+PF15251 Domain of unknown function (DUF4588)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 274 amino acids in length. There is a conserved LYK sequence motif. There is a single completely conserved residue A that may be functionally important.. 
+PF15252 Domain of unknown function (DUF4589)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.. 
+PF15253 SCL-interrupting locus protein N-terminus<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15254 Coiled-coil domain-containing protein 14<br>Eberhardt RY, Coggill P, Hetherington K. This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.. 
+PF15255 WASH complex subunit CAP-Z interacting, central region<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.. 
+PF15256 SPATIAL<br>Eberhardt RY, Coggill P, Hetherington K. SPATIAL (stromal protein associated with thymii and lymph node) proteins may be involved in spermatid differentiation  .. 
+PF15257 Domain of unknown function (DUF4590)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins remains to be characterised and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.. 
+PF15258 Protein family of FAM222A<br>Eberhardt RY, Coggill P, Hetherington K. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.. 
+PF15259 G-2 and S-phase expressed 1<br>Eberhardt RY, Coggill P, Hetherington K. This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localised to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis.  This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.. 
+PF15260 Protein family FAM219A<br>Eberhardt RY, Coggill P, Hetherington K. This protein family, FAM219A is a domain of unknown function. This protein family has been found in eukaryotes. Proteins in this family are typically between 144 and 191 amino acids in length. There are two conserved sequence motifs: QLL and LDE.. 
+PF15261 Domain of unknown function (DUF4591)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function. It is found in eukaryotes, and is approximately 120 amino acids in length. In humans, the gene encoding this protein lies in the position chromosome 11 open reading frame 63.. 
+PF15262 Domain of unknown function (DUF4592)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.. 
+PF15263 Domain of unknown function (DUF4593)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a putative uncharacterised protein family. Its existence is uncertain and its precise function is unknown. This family of proteins is thought to be found in eukaryotes. Proteins in this family are estimated to be around 155 amino acids in length.. 
+PF15264 Tumour suppressing sub-chromosomal transferable candidate 4<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted [1,2]. This same cluster is associated with the Beckwith-Wiedermann syndrome  .  This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.. 
+PF15265 FAM186A;<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function.  This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.. 
+PF15266 Domain of unknown function (DUF4594)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.. 
+PF15268 Dapper<br>Eberhardt RY, Coggill P, Hetherington K. This is a family of signalling proteins [1-2]. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers  .. 
+PF15269 Zinc-finger<br>Eberhardt RY, Coggill P, Hetherington K. this is a family of eukaryotic zinc-fingers.. 
+PF15270 Metallo-carboxypeptidase inhibitor <br>Pfam-B_261362 (release 26.0). ACI44, a metallo-carboxypeptidase inhibitor, is one member of a battery of selective inhibitors protecting roundworms of the genus Ascaris, common parasites of the human gastrointestinal tract, from host enzymes and the immune system  .. 
+PF15271 Spindle pole body component BBP1, Mps2-binding protein<br>Pfam-B_31027 (release 26.0). This N-terminal domain of BBP1, a spindle pole body component, interacts directly, though transiently, with the polo-box domain of Cdc5p. full length BBP1 localises at the cytoplasmic side of the central plaque periphery of the spindle pole body (SPB) and plays an important role in inserting a duplication plaque into the nuclear envelope and assembling a functional inner plaque  . Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge  .. 
+PF15272 Spindle pole body component BBP1, C-terminal<br>Pfam-B_58229 (release 26.0). This C-terminal domain of BBP1, a spindle pole body component, carries coiled-coils that are necessary for the localisation of BBP1 to the spindle pole body (SPB)  . Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge  . 
+PF15273 NHS-like<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins includes Nance-Horan syndrome protein (NHS)  .. 
+PF15274 Muscular LMNA-interacting protein<br>Eberhardt RY, Coggill P, Hetherington K. MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localises with lamin A and C in the nuclear envelope. MLIP also co-localises with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP  .. 
+PF15275 PEHE domain<br>Eberhardt RY, Coggill P, Hetherington K. This domain was first identified in drosophila MSL1 (male-specific lethal 1)  . In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3) [2-3].. 
+PF15276 Protein phosphatase 1 binding<br>Eberhardt RY, Coggill P, Hetherington K. This domain contains a protein phosphatase 1 (PP1) binding site  .. 
+PF15277 Exocyst complex component SEC3 N-terminal PIP2 binding PH<br>This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the PIP2 head group are conserved. The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables  .. 
+PF15278 Sec3 exocyst complex subunit<br>This small Sec3 C-terminal domain family is based around the fission yeast protein, and is rather shorter than the budding yeast/vertebrate domain Sec3_C, family. Pfam:PF09763. In fact it is only this coiled-coil region that they carry in common. The full length fission yeast, UniProtKB:Q10324, protein Sec3 is redundant with Exo70 for viability and for the localisation of other exocyst subunits, suggesting that these components act as exocyst tethers at the plasma membrane. Sec3, Exo70 and Sec5 are transported by the myosin V Myo52 along actin cables. The exocyst holo-complex, including Sec3 and Exo70, is present on exocytic vesicles, which can reach cell poles by either myosin-driven transport or random walk  .. 
+PF15279 Sine oculis-binding protein<br>Eberhardt RY, Coggill P, Hetherington K. SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif.  SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis  . the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein [1,2].. 
+PF15280 Protein aurora borealis N-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is required for the activation of the protein kinase Aurora-A  .. 
+PF15281 Consortin C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. Consortin is a trans-Golgi network cargo receptor involved in targeting connexins to the plasma membrane  .. 
+PF15282 BMP-2-inducible protein kinase C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family represents the C-terminus of BMP2K and related proteins [1-2].. 
+PF15283 Domain of unknown function (DUF4595) with porin-like fold<br>JCSG target SP16885A/PDB 4ghb. Large family of predicted secreted proteins mostly from  CFG group, but also from Burkholderia, Pseudomonas and Streptomyces. Function of these proteins is not known. A 3D structure of a representative of this family from  Bacteroides uniformis was solved by JCSG and deposited to PDB as 4ghb. There is some overlap with RHS-repeat (PF05593) family despite lack of obvious repeats in the structure. 
+PF15284 Phage-encoded virulence factor<br>Pfam-B_45688 (release 26). PAGK represents a new of virulence factors that is translocated into the host cytoplasm via bacterial outer membrane vesicles (OMV). Members are small proteins composed of ¡­70 amino acids. In Salmonella they are secreted independently of the SPI-2 type-III secretion system, T3SS. The OMV functions as a vehicle for transferring virulence determinants to the cytoplasm of the infected host cell. OMVs are released from the cell envelopes of Gram-negative bacteria and comprise a variety of outer membrane and periplasmic constituents, including proteins, phospholipids, lipopolysaccharides, and DNA  .. 
+PF15285 Beclin-1 BH3 domain, Bcl-2-interacting<br>The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.. 
+PF15286 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like<br>Pfam:PF02180.  Bcl-2_3 is a small family of eukaryotic proteins associated with autophagy. The family is found in association with Pfam:PF00452,. 
+PF15287 KRBA1 family repeat<br>KRBA1 is a short repeating motif found in mammalian proteins. It is characterised by a highly conserved sequence of residues, SSPLxxLxxCLK.  The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins.. 
+PF15288 Zinc knuckle<br>This Zinc knuckle is found in FAM90A mammalian proteins.. 
+PF15289 Regulatory factor X-associated C-terminal binding domain<br>This C-terminal domain of Regulatory factor X-associated protein binds to RFXANK [1,2], the Ankyrin-repeat regulatory factor X proteins. RFXA is part of the RFX complex, Mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes  .. 
+PF15290 Golgi-localised syntaxin-1-binding clamp<br>Eberhardt RY, Coggill P, Hetherington K. Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.. 
+PF15291 Dermcidin, antibiotic peptide<br>Dermcidin is a family of peptides produced in the sweat to protect against pathogenic Gram-positive bacteria.. 
+PF15292 Treslin N-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation [1-2].. 
+PF15293 Nuclear fragile X mental retardation-interacting protein 2<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15294 Leucine zipper<br>Eberhardt RY, Coggill P, Hetherington K. This family includes Leucine zipper transcription factor-like protein 1 (LZTFL1)   and Leucine zipper protein 2 (LUZP2)  .. 
+PF15295 Coiled-coil domain-containing protein 50  N-terminus<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15296 Codanin-1 C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found near to the C-terminus of codanin-1  . . 
+PF15297 Cytoskeleton-associated protein 2 C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family includes the C-terminus of CKAP2 and CKAP2L. CKAP2 is a microtubule associated protein which stabilises microtubules  .. 
+PF15298 AJAP1/PANP C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family includes the C-terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration  . PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha  .. 
+PF15299 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein  .. 
+PF15300 INTS6/SAGE1/DDX26B/CT45 C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.. 
+PF15301 SLAIN motif-containing family<br>Eberhardt RY, Coggill P, Hetherington K. The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1  . They are a family of microtubule plus-end tracking proteins  .. 
+PF15302 P33 mono-oxygenase<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins contains a flavine-containing mono-oxygenase motif. It may have a role in the regulation of neuronal survival, differentiation and axonal outgrowth  .. 
+PF15303 E3 ubiquitin-protein ligase Arkadia N-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found at the N-terminus of E3 ubiquitin-protein ligase Arkadia  .. 
+PF15304 A-kinase anchor protein 2 C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds  .. 
+PF15305 Intraflagellar transport protein 43<br>Eberhardt RY, Coggill P, Hetherington K. Intraflagellar transport protein 43 (IFT43) is a subunit of the IFT complex A (IFT-A) machinery of primary cilia  .. 
+PF15306 LIN37<br>Eberhardt RY, Coggill P, Hetherington K. LIN37 is a component of the DREAM (or LINC) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [1-2].. 
+PF15307 Sperm acrosome-associated protein 7<br>SPACA7 is a family of eukaryotic proteins expressed in the testes. Proteins in this family are typically between 104 and 195 amino acids in length. There is a conserved DEIL sequence motif. The function is not known.. 
+PF15308 CEP170 C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170)  .. 
+PF15309 ALMS motif<br>Eberhardt RY, Coggill P, Hetherington K. This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), KIAA1731 and C10orf90 [1-2].. 
+PF15310 Vitamin A-deficiency (VAD) rat model signalling<br>VAD1-2 is a family of proteins found in eukaryotes. The family is expressed in testes and is involved in signalling during spermatogenesis.. 
+PF15311 Hydrolethalus syndrome protein 1 C-terminus<br>Eberhardt RY, Coggill P, Hetherington K. 
+PF15312 Junctional sarcoplasmic reticulum protein<br>JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalises with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.. 
+PF15313 Hexamethylene bis-acetamide-inducible protein<br>Eberhardt RY, Coggill P, Hetherington K. HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.. 
+PF15314 Proline-rich acidic protein 1, pregnancy-specific uterine<br>PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homologue. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression  .. 
+PF15315 Facioscapulohumeral muscular dystrophy candidate 2<br>This family of proteins is found in eukaryotes. The family is localised close to the D4Z4 repeats on chromosome 4 and 10 that are associated with the autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). FRG2 are transcriptionally upregulated in FSHD myoblast cultures suggesting involvement in the pathogenesis of FSHD  .. 
+PF15316 MyoD family inhibitor<br>Eberhardt RY, Coggill P, Hetherington K. Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors  . They affect axin-mediated regulation of the Wnt and JNK signaling pathways  , and regulate expression from viral promoters  .. 
+PF15317 Cardiac transcription factor regulator, Developmental protein<br>Eberhardt RY, Coggill P, Hetherington K. The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart  .  More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions  . This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.. 
+PF15318 Putative Bcl-2 like protein of testis<br>This family of proteins is found in eukaryotes. The family may represent a set of Bcl-2-like proteins involved in apoptosis, see UniProt:Q9BQM9.. 
+PF15319 RAD9, RAD1, HUS1-interacting nuclear orphan protein<br>RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins  . Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N  .. 
+PF15320 mRNA cap methylation, RNMT-activating mini protein<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 154 amino acids in length. There is a single completely conserved residue D that may be functionally important.  RAM is a family of eukaryotic proteins that are an obligate component of the mammalian cap methyltransferase, RNMT (RNA guanine-7 methyltransferase). RAM consists of an N-terminal RNMT-activating domain and a C-terminal RNA-binding domain. Either RAM or RNMT independently have rather weak binding affinity for RNA, but together their RNA affinity is significantly increased. RAM is necessary for efficient cap methylation, maintaining mRNA expression levels, for mRNA translation and for cell viability.. 
+PF15321 ATPase family AAA domain containing 4<br>ATAD4 is a family of proteins is found in eukaryotes. The family is also known as PRR15L, or proline-rich 15-like. ATAD4 is expressed almost exclusively in post-mitotic cells both during foetal development and in adult tissues, such as the intestinal epithelium and the testis. Its expression in mouse and human gastrointestinal tumours is linked, directly or indirectly, to the disruption of the Wnt signaling pathway.. 
+PF15322 Protein missing in infertile sperm 1, putative<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 249 and 341 amino acids in length.. 
+PF15323 Developmental protein<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins are found in eukaryotes. These proteins have an important role to play in developmental biology, particularly embryogenesis. It plays an important role in cell survival and axial pattern  . It is also thought to be a crucial subunit in the tRNA splicing ligase complex . Proteins in this family are typically between 141 and 232 amino acids in length. There are two conserved sequence motifs: HPE and PQR.. 
+PF15324 Hedgehog signalling target<br>Eberhardt RY, Coggill P, Hetherington K. TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.. 
+PF15325 Modulator of retrovirus infection<br>MRI, or modulator of retrovirus infection, is a family of eukaryotic proteins that regulate the activity of the proteasome in the uncoating of retroviruses  .. 
+PF15326 Testis expressed sequence 15<br>TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination  . Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population  .. 
+PF15327 Tankyrase binding protein C terminal domain<br>Eberhardt RY, Coggill P, Hetherington K. This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyses poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase  . The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.. 
+PF15328 Putative GRINL1B complex locus protein 2<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is named Putative GRINL1B complex locus protein 2. GRINL1B is short for: glutamate receptor, ionotropic, N-methyl D-aspartate-like 1B. The name indicates what sort of receptor it is thought to be, a ligand gated ion channel specific to the neurotransmitter Glutamate. This family of proteins is found in eukaryotes. Proteins in this family are typically between 325 and 463 amino acids in length. The protein is thought to be the product of a pseudogene with a role in helping assemble a gene transcription unit  .. 
+PF15330 SHP2-interacting transmembrane adaptor protein, SIT<br>SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.. 
+PF15331 Cellular tumour antigen p53-inducible 5<br>TP53IP5 suppresses cell growth, and its intracellular location and expression change in a cell-cycle-dependent manner.. 
+PF15332 Lck-interacting transmembrane adapter 1<br>LIME1 is a family of eukaryotic transmembrane adaptors. It plays an important role in linking BCR stimulation to B-cell activation and is expressed in primary B cells. LIME localises to lipid rafts in T cells in response to TCR stimulation  , and is phosphorylated by Lck and recruits signalling molecules such as Lck, PI3K, Grb2, Gads, and SHP-2  . LIME acts as the transmembrane adaptor linking BCR-induced membrane-proximal signalling to B-cell activation  .. 
+PF15333 TATA box-binding protein-associated factor 1D<br>TAF1D is a family of eukaryotic proteins that are members of the SL1 complex The SL1 complex includes TBP and TAF1A, TAF1B and TAF1C, and plays a role in RNA polymerase I transcription [1,2]. Alternatives names have included 'JOSD3, Josephin domain containing 3'.. 
+PF15334 Aurora kinase A and ninein interacting protein<br>AIB is a family of eukaryotic proteins necessary for the adequate functioning of Aurora-A, a protein involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and aspects of tumourigenesis. AIB is likely to act as a regulator of Aurora-A activity.. 
+PF15335 Caspase activity and apoptosis inhibitor 1<br>CAAP1, or caspase activity and apoptosis inhibitor 1, is a family of eukaryotic proteins involved in the regulation of apoptosis. It modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.. 
+PF15336 Autism susceptibility gene 2 protein<br>Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism   and with influencing the number of corpora lutea produced by breeding sows  .. 
+PF15337 Vascular protein family Vasculin-like 1<br>Eberhardt RY, Coggill P, Hetherington K. GC-rich promoter-binding protein 1-like 1 or Vasculin-like protein family 1, is likely to be a transcription factor. The domain family is found in eukaryotes, and is approximately 90 amino acids in length.. 
+PF15338 p53-regulated apoptosis-inducing protein 1<br>TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localised within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.. 
+PF15339 Acrosome formation-associated factor<br>Afaf is a family of single pass type I membrane proteins. Afaf is a vesicle factor derived from the early endosome trafficking pathway that is involved in the biogenesis of the acrosome on the maturing spermatozoon head.. 
+PF15340 Cooperator of PRMT5 family<br>COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyses the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.. 
+PF15341 Ribosome biogenesis protein SLX9<br>Eberhardt RY, Coggill P, Hetherington K. SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences  .. 
+PF15342 FAM212 family<br>Eberhardt RY, Coggill P, Hetherington K. This domain family is found in eukaryotes, and is approximately 60 amino acids in length.. 
+PF15343 Decidual protein induced by progesterone family<br>DEPP is a family of proteins expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels are found during the first trimester.  Its expression is induced by progesterone, testosterone and, to a much lower extent, oestrogen. The family is alternatively known as fasting-induced gene protein, FIG.. 
+PF15344 FAM217 family<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.. 
+PF15345 Transmembrane protein 51<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 253 amino acids in length.. 
+PF15346 Arginine and glutamate-rich 1<br>ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.. 
+PF15347 Phosphoprotein associated with glycosphingolipid-enriched<br>PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.. 
+PF15348 Gemini of Cajal bodies-associated protein 8<br>Eberhardt RY, Coggill P, Hetherington K. GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm  . The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer  .. 
+PF15349 DDB1- and CUL4-associated factor 16<br>DCA16 is a family of eukaryotic proteins that interacts with DDB1 and CUL4A. The family may function as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex  .. 
+PF15350 Ewing's tumour-associated antigen 1 homologue<br>This family of proteins is found in eukaryotes, where members are expressed at high levels in the brain, liver kidney and Ewing tumour cell lines. Proteins in this family are typically between 648 and 898 amino acids in length.. 
+PF15351 Junctional protein associated with coronary artery disease<br>JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells.  The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localises close to the apical membrane in epithelial cells. This family is found in eukaryotes.. 
+PF15352 Susceptibility to monomelic amyotrophy<br>This family of proteins is associated with a susceptibility to monomelic amyotrophy.. 
+PF15353 Headcase protein family homologue<br>Eberhardt RY, Coggill P, Hetherington K. HECA was characterised first in Drosophila where it regulates the proliferation and differentiation of cells during adult morphogenesis. In humans, HECA affects cell cycle progression and proliferation in head and neck cancer cells. It by slows down cell division of oral squamous cell carcinoma cells and may thereby act as a tumour-suppressor in head and neck cancers.   . 
+PF15354 Kidney-associated antigen 1<br>KAAG1, kidney-associated antigen 1, or RU2AS (RU2 antisense gene protein) has been found in mammals. It is expressed in testis and kidney, and, at lower levels, in urinary bladder and liver. It is expressed by a high proportion of tumours of various histologic origin, including melanomas, sarcomas and colorectal carcinomas.. 
+PF15355 Stretch-responsive small skeletal muscle X protein, Chisel<br>The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.. 
+PF15356 Psoriasis susceptibility locus 2<br>SPR1 is psoriasis susceptibility locus 2 protein family.. 
+PF15357 Psoriasis susceptibility 1 candidate 1<br>This family is considered a candidate for susceptibility to psoriasis.. 
+PF15358 Testis-specific serine kinase substrate<br>TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ  . Recently it has been shown in human testis to be localised to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function  . TSKS is localised during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis  .. 
+PF15359 Carnitine deficiency-associated protein 3<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 251 amino acids in length. CDV3 is also known as TPP36 - tyrosine-phosphorylated protein 36. The function is not known.. 
+PF15360 APJ endogenous ligand<br>Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control  . Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes.  It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis  . As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis  .. 
+PF15361 Resistance to inhibitors of cholinesterase homologue 3<br>Eberhardt RY, Coggill P, Hetherington K. RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.. 
+PF15362 Enamelin<br>ENAMELIN is involved in the mineralisation and structural organisation of enamel. It is necessary for the extension of enamel during the secretory stage of dental enamel formation. The proteins are expressed in teeth, particularly in odontoblasts, ameloblasts and cementoblasts.. 
+PF15363 Domain of unknown function (DUF4596)<br>Eberhardt RY, Coggill P, Hetherington K. This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.. 
+PF15364 PAXIP1-associated-protein-1 C term PTIP binding protein<br>Eberhardt RY, Coggill P, Hetherington K. This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localise at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length  .. 
+PF15365 Proline-rich nuclear receptor coactivator<br>Eberhardt RY, Coggill P, Hetherington K. The PNRC family, proline-rich nuclear receptor coactivator, is found in eukaryotes, and is approximately 60 amino acids in length. There is a conserved YAG sequence motif.. 
+PF15366 Domain of unknown function (DUF4597)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 63 and 76 amino acids in length. There is a conserved TPPTPT sequence motif.. 
+PF15367 Calcium-binding and spermatid-specific protein 1<br>CABS1 is a family of proteins found in eukaryotes. It is also known as NYD-SP26. It binds calcium and is specifically expressed in the elongate spermatids and then localised into the principal piece of flagella of matured spermatozoa.. 
+PF15368 Spermatogenesis family BioT2<br>BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis [1,2,3].. 
+PF15369 Uncharacterised protein KIAA1328<br>Eberhardt RY, Coggill P, Hetherington K. This function of this protein family remains uncharacterised. This family of proteins is found in eukaryotes.. 
+PF15370 Domain of unknown function (DUF4598)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 159 and 251 amino acids in length.. 
+PF15371 Domain of unknown function (DUF4599)<br>The function of this family of eukaryotic proteins is not known.. 
+PF15372 Domain of unknown function (DUF4600)<br>
+PF15373 Domain of unknown function (DUF4601)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function, which is found in eukaryotes. In humans, the gene encoding this protein is found in the position, chromosome 19 open reading frame 45.. 
+PF15374 Coiled-coil domain-containing protein 71L<br>Eberhardt RY, Coggill P, Hetherington K. The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.. 
+PF15375 Domain of unknown function (DUF4602)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 173 and 294 amino acids in length. This family includes Human C1orf131.. 
+PF15376 Domain of unknown function (DUF4603)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function. In particular, this domain lies at the C-terminal end of a protein found in eukaryotes.. 
+PF15377 Domain of unknown function (DUF4604)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 141 and 174 amino acids in length and contain a conserved LSF sequence motif.. 
+PF15378 Domain of unknown function (DUF4605)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 82 and 137 amino acids in length.. 
+PF15379 Domain of unknown function (DUF4606)<br>This domain family is found in eukaryotes, and is approximately 100 amino acids in length.. 
+PF15380 Domain of unknown function (DUF4607)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 207 and 359 amino acids in length.. 
+PF15381 Domain of unknown function (DUF4608)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 85 and 157 amino acids in length.. 
+PF15382 Domain of unknown function (DUF4609)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 70 and 139 amino acids in length.. 
+PF15383 Transmembrane protein 237<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is found in eukaryotes. The function of this protein is to aid the production of new cilia in ciliogenesis. Mutations in the protein cause a disease, named Joubert syndrome type 14 (JBTS14) and also affect cell signalling using the Wnt pathway . Proteins in this family are typically between 203 and 512 amino acids in length. There are two completely conserved G residues that may be functionally important.. 
+PF15384 Domain of unknown function (DUF4610)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 164 and 206 amino acids in length. There is a conserved NPG sequence motif.. 
+PF15385 Specifically androgen-regulated gene protein<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue  . Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.. 
+PF15386 PRR14;<br>Drosophila Tantalus-like. Iyer LM, Aravind L, Eberhardt RY, Coggill P, Hetherington K. An alpha+beta fold domain found in metazoan proteins such as   Drosophila Tantalus  . Drosophila Tantalus binds the chromatin protein Additional sex combs (Asx) and also binds DNA in vitro  .. 
+PF15387 Domain of unknown function (DUF4611)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 71 and 100 amino acids in length. There is a conserved AKR sequence motif.. 
+PF15388 Protein Family FAM117<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.. 
+PF15389 Domain of unknown function (DUF4612)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 109 and 323 amino acids in length.. 
+PF15390 Domain of unknown function (DUF4613)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 625 and 725 amino acids in length.. 
+PF15391 Domain of unknown function (DUF4614)<br>This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a conserved EALT sequence motif.. 
+PF15392 Joubert syndrome-associated<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis .. 
+PF15393 Domain of unknown function (DUF4615)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 161 and 229 amino acids in length. There is a single completely conserved residue F that may be functionally important.. 
+PF15394 Domain of unknown function (DUF4616)<br>Eberhardt RY, Coggill P, Hetherington K. This protein family is a domain of unknown function found at the C-terminal domain of the proteins. This protein family is found in eukaryotes. Proteins in this family are typically between 166 and 538 amino acids in length.. 
+PF15395 Domain of unknown function (DUF4617)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.. 
+PF15396 Protein Family FAM60A<br>Eberhardt RY, Coggill P, Hetherington K. This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression  . Proteins in this family are typically between 179 and 324 amino acids in length.. 
+PF15397 Domain of unknown function (DUF4618)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.. 
+PF15398 Domain of unknown function (DUF4619)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 299 amino acids in length.. 
+PF15399 Domain of unknown function (DUF4620)<br>
+PF15400 Testis-expressed sequence 33 protein family<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 147 and 280 amino acids in length. There are two conserved sequence motifs: NIRH and SYT. The function is not known.. 
+PF15401 Tryptophan-ring motif of head of Trimeric autotransporter adhesin<br>TAA-head_Trp-ring is the tryptophan-ring motif of some Gram-negative Enterobacteriaceae. The Trp-ring folds into a beta-meander type on the top of the head domain of its trimeric autotransporter adhesin proteins. In conjunction with the GIN domain it is thought to be the region of the head that adheres to fibronectin.. 
+PF15402 N-terminus of kinetochore NMS complex subunit Spc7<br>
+PF15403 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN)<br>HiaBD2_N may represent the GIN domain of the Head region of TAAs - trimeric autotransporter adhesins. Not all TAAs carry this domain; however, in those that do, the GIN in combination with the Trp-ring domain is necessary for adhesion to fibronectin in the host cell.. 
+PF15404 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15405 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15406 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15407 Sporulation protein family 7<br>Pfam-B_51974 (release 26.0). Spo7_2 constitutes a different set of fungal and related species from those found in Spo7.  This domain is found in general at the N-terminus. In many members the domain is associated with a Pleckstrin-homology - PH - domain.. 
+PF09061 Stirrup<br>Bio::Pfam::PfamLiveDBManager=HASH(0x4ef6130). The Stirrup domain, found in the prokaryotic protein ribonucleotide reductase, has a molecular mass of 9 kDa and is folded into an alpha/beta structure. It allows for binding of the reductase to DNA via electrostatic interactions, since it has a predominance of positive charges distributed on its surface  .. 
+PF15408 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15409 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15410 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15411 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15412 Binding domain of Nse4/EID3 to Nse3-MAGE<br>This family includes Nse4 and EID3 members  , that bind over this region to the Nse3 pocket, in MAGE family Pfam:PF01454  .. 
+PF15413 Pleckstrin homology domain<br>This Pleckstrin homology domain is found in some fungal species.. 
+PF15414 Protein of unknown function (DUF4621)<br>JCSG:Target_394740-GS13541A. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 350 amino acids in length.. 
+PF15415 Protein of unknown function (DUF4622)<br>JCSG:Target_390149-GS13960A. This family of proteins is found in bacteria. Proteins in this family are typically between 348 and 360 amino acids in length.. 
+PF15416 Domain of unknown function (DUF4623)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 470 amino acids in length. There are two conserved sequence motifs: HLL and RYL.. 
+PF15417 Domain of unknown function (DUF4624)<br>JCSG:Target_390388-GS13780A. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.. 
+PF15418 Domain of unknown function (DUF4625)<br>JCSG:Target_390125-GS13882B. This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.. 
+PF15419 Leukemia NUP98 fusion partner 1<br>This family of proteins includes leukemia NUP98 fusion partner 1, the gene encoding this protein is involved in a chromosomal translocation with the NUP98 locus in a form of T-cell acute lymphoblastic leukemia  .. 
+PF15420 Alpha/beta-hydrolase family N-terminus<br>This is the N-terminal transmembrane domain of a family of alpha/beta hydrolases which may function as lipases. The C-terminal domain (Pfam:PF10081) is the catalytic domain  .. 
+PF15421 Putative polysaccharide deacetylase<br>JCSG:Target_416920-SP13771A. 
+PF15422 Domain of unknown function (DUF4626)<br>
+PF15423 FLYWCH-type zinc finger-containing protein<br>This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with Pfam:PF04500. There are two conserved sequence motifs: EQE and QEPS.. 
+PF15424 Odontogenic ameloblast-associated family<br>
+PF15425 Domain of unknown function (DUF4627)<br>This family of proteins is found in bacteria. Proteins in this family are approximately 230 amino acids in length. There is a conserved WYK sequence motif.. 
+PF15427 S100P-binding protein<br>S100PBPR is a family of proteins found in eukaryotes, and localised to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridisation shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.. 
+PF15428 Immunity protein 14<br>A predicted immunity protein with mostly all-beta fold and several conserved hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1 or Tox-HNH family  . The protein is also found heterogeneous polyimmunity loci.. 
+PF15429 Domain of unknown function (DUF4628)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 152 and 673 amino acids in length.. 
+PF15430 Single domain von Willebrand factor type C<br>
+PF15431 Transmembrane protein 190<br>
+PF15432 Accessory Sec secretory system ASP3<br>Sec-ASP3 is family of bacterial proteins involved in the Sec secretory system. The family forms part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell-wall glycoprotein adhesin encoded upstream in the same operon.. 
+PF15433 Mitochondrial 28S ribosomal protein S31<br>Eberhardt RY, Coggill P, Hetherington K. MRP-S31 is the mitochondrial 28S ribosomal subunit S31. This family of proteins is found in eukaryotes. Proteins in this family are typically between 246 and 395 amino acids in length. There are two conserved sequence motifs: RHFMELV and GLSKN.. 
+PF15434 Family 104<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 113 and 185 amino acids in length. There is a conserved SLQ sequence motif.. 
+PF15435 UNC119-binding protein C5orf30 homologue<br>UNC119_bdg is a family of eukaryotic proteins that probably plays a role in trafficking of proteins, via interaction with unc119 family cargo adapters. The family may play a role in ciliary membrane localisation.. 
+PF15436 Plasminogen-binding protein pgbA N-terminal<br>PGBA_N is an N-terminal family of bacterial proteins that bind plasminogen. This activity was identified in In Helicobacter pylori where it is thought to contribute to the virulence of this bacterium. Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a Pg activator.. 
+PF15437 Plasminogen-binding protein pgbA C-terminal<br>PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium.  Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.. 
+PF15438 Antigenic membrane protein of phytoplasma<br>Phyto-Amp is a family of phytopathogenic wall-less bacterial antigenic membrane proteins  . The bacteria are limited to the phloem and pose a major threat to agriculture worldwide. They are transmitted in a persistent, propagative manner by phloem-sucking Hemipteran insects. Phytoplasma membrane proteins are in direct contact with hosts and are assumed to be involved in determining vector specificity. Phyto-Amp is thought to be one family of proteins that mediates such specificity. The proteins appear to be encoded by circular extrachromosomal elements, at least one of which is a plasmid  .. 
+PF15439 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter<br>NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8  . However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice  .. 
+PF15440 THRAP3/BCLAF1 family<br>This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay  . It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1)  .. 
+PF15441 Rho guanine nucleotide exchange factor 5/35<br>This family includes Rho guanine nucleotide exchange factor 5   and Rho guanine nucleotide exchange factor 35.. 
+PF15442 Domain of unknown function (DUF4629)<br>This domain family is found in eukaryotes, and is approximately 150 amino acids in length. There are two conserved sequence motifs: MHML and LGKK.. 
+PF15443 Domain of unknown function (DUF4630)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 124 and 286 amino acids in length.. 
+PF15444 Transmembrane protein 247<br>This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 197 and 222 amino acids in length. The function of this family is unknown.. 
+PF15445 acidic terminal segments, variant surface antigen of PfEMP1<br>ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1)  . this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.. 
+PF15446 PHD/FYVE-zinc-finger like domain<br>Pfam-B_5236 (release 26.0). This family appears to be a combination domain of several consecutive zinc-binding regions.. 
+PF15447 N-terminal segments of PfEMP1<br>NTS, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors  . A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1α1), shows this region is directly implicated in rosetting.  NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1α domain that is found to be the important heparin-binding site  . This family is closely associated with PFEMP, Pfam:PF03011, and Duffy_binding, Pfam:PF05424.. 
+PF15448 N-terminal segments of P. falciparum erythrocyte membrane protein<br>NTS_2 is a family of the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1)  . However, in this group of proteins conservation is high. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors.. 
+PF15449 Retinal protein<br>This family of proteins is found in the photoreceptor cells of the retina [1,2]. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy [1-4]. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina [2-3].. 
+PF15450 Domain of unknown function (DUF4631)<br>This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 394 and 668 amino acids in length.. 
+PF15451 Domain of unknown function (DUF4632)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 59 and 190 amino acids in length.. 
+PF15452 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter<br>NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8  . However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice  .. 
+PF15453 Protein incorporated later into Tight Junctions<br>Pilt is a family of eukaryotic tight junction-proteins that binds to guanylate-kinase. Pilt is a component of TJs (Tight junctions) rather than AJs (Adhesin junctions). The protein is incorporated into TJs after TJ strands are formed, thereby suggesting the name Pilt for 'protein incorporated later into TJs'. Pilt binds to the guanylate-kinase region of hDlg otherwise known as Disk large homologue  .. 
+PF15454 Late endosomal/lysosomal adaptor and MAPK and MTOR activator<br>LAMTOR is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes. It is found to be one of three small proteins constituting the Rag complex or Ragulator that interact with each other, localise to endosomes and lysosomes, and play positive roles in the MAPK pathway. The complex does this by interacting with the Rag GTPases, recruiting them to lysosomes, and bringing about mTORC1 activation.. 
+PF15455 Proline-rich 19<br>This family includes proline-rich protein 19.. 
+PF15456 Up-regulated During Septation<br>Uds1 is a domain family is found mostly in fungi, and is typically between 120 and 138 amino acids in length. The GO annotation for the S.pombe protein describes the protein as barrier septum assembly involved in cell cycle cytokinesis, GO:0071937. Many of the uncharacterised members are listed as being involucrin repeat proteins, but this can not be substantiated.. 
+PF15457 Type III T3SS secreted effector HopW1-1/HopPmaA<br>HopW1-1 is a family of bacterial modular P. syringae Avr effectors that induce accumulation of the signal molecule salicylic acid (SA) and the transcripts of HWI1 (HOPW1-1-INDUCED GENE1) in Arabidopsis. Thus HopW1-1 elicits a resistance response in Arabidopsis  .. 
+PF15458 Nineteen complex-related protein 2<br>NTR2 or Nineteen complex-related protein 2 is a family of largely fungal and plant proteins that form a complex with the DExD/H-box RNA helicase Prp43. Along with NTR1 it is an accessory factor of Prp43 in catalysing spliceosome disassembly.  Disassembly of the spliceosome after completion of the splicing reaction is necessary for recycling of splicing factors to promote efficient splicing  . NTR2 and NTR1 associate with a post-splicing complex containing the excised intron and the spliceosomal U2, U5, and U6 snRNAs, that supports a link with a late stage in the pre-mRNA splicing process  .. 
+PF15459 60S ribosome biogenesis protein Rrp14<br>Pfam-B_10508 (release 26.0). RRP14 is a family of nucleolar 60S ribosomal biogenesis proteins from eukaryotes. RRP14 functions in ribosome synthesis as it is required for the maturation of both small and large subunit rRNAs and it helps to prevent premature cleavage of the pre-rRNA at site C2  . It also plays a role in cell polarity and/or spindle positioning 2],. 
+PF15460 Something about silencing, SAS, complex subunit 4<br>SAS4 is a family of largely fungal silencing regulators. This silencing is mediated by chromatin. SAS4 specifically silences the yeast mating-type genes HML and HMR  . SAS4 is found to be one subunit of a complex, the SAS complex, that interacts with chromatin assembly factor Asf1p, and asf1 mutants show silencing defects similar to mutants in the SAS complex. Thus, ASF1-dependent chromatin-assembly may mediate the role of the SAS complex in silencing  . Co-expression of Sas2, SAS4, and Sas5 in Escherichia coli leads to formation of a stable SAS complex that acetylates histones. SAS4 is essential for the acetyltransferase activity of Sas2, and Sas5 is also important  .. 
+PF15461 Beta-carotene 15,15'-dioxygenase<br>BCD is a family of bacterial and archaeal proteins is found in bacteria and archaea that catalyse or regulate the conversion of beta-carotene to retinal  . Characterisation of BCD proteins shows them to cleave beta-carotene at its central double bond (15,15′) to yield two molecules of all-trans-retinal. However, the oxygen atom of retinal originated not from water but from molecular oxygen, suggesting that the enzyme was a beta-carotene 15,15′-dioxygenase, rather than a mono-oxygenase that catalyzes the same biochemical reaction [2,3].. 
+PF15462 Bartter syndrome, infantile, with sensorineural deafness (Barttin)<br>Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.. 
+PF15463 Extracellular mutant protein 11<br>ECM11 is a family of largely fungal proteins. ECM11 interacts with Cdc6, an essential protein involved in the initiation of DNA replication, and is a nuclear protein involved in maintaining chromatin structure  . It was previously identified as a protein involved in yeast cell wall biogenesis and organisation, but is also found to be required in meiosis where its function is related to DNA replication and crossing-over  .. 
+PF15464 Domain of unknown function (DUF4633)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 123 amino acids in length.. 
+PF15465 Domain of unknown function (DUF4634)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 98 and 133 amino acids in length.. 
+PF15466 Domain of unknown function (DUF4635)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 120 and 154 amino acids in length. There are two conserved sequence motifs: LEQ and DLE.. 
+PF15467 Secretogranin-3<br>Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed.  These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells  . SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells  . Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion  .. 
+PF15468 Domain of unknown function (DUF4636)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 196 and 244 amino acids in length.. 
+PF15469 Exocyst complex component Sec5<br>Pfam-B_353125 (release 26.0). This Sec5 family of eukaryotic proteins conserved is not representing the Sec5-Ral binding site.. 
+PF15470 Domain of unknown function (DUF4637)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 142 and 178 amino acids in length.. 
+PF15471 Transmembrane protein family 171<br>This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.. 
+PF15472 Domain of unknown function (DUF4638)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 240 and 272 amino acids in length.. 
+PF15473 PEST, proteolytic signal-containing nuclear protein family<br>Eberhardt RY, Coggill P, Hetherington K. PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation  .. 
+PF15474 Meiotically up-regulated gene family<br>This protein was identified as being up-regulated during meiosis in S.pombe.  This family of proteins is found in largely in plants and fungi. Proteins in this family are typically between 128 and 920 amino acids in length.. 
+PF15475 Transmembrane protein C12orf23, UPF0444<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 119 amino acids in length.. 
+PF15476 Histone deacetylase complex subunit SAP25<br>SAP25 is a family of proteins found in eukaryotes. SAP25 is a core component of the mSin3 co-repressor complex whose subcellular location is regulated by PML. mSin3, the transcriptional co-repressor, is associated with histone deacetylases (HDACs) and is utilised by many DNA-binding transcriptional repressors. SAP25 is a nucleo-cytoplasmic shuttling protein that is actively exported from the nucleus by a CRM1-dependent mechanism. It binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA [1,2].. 
+PF15477 Small acidic protein family<br>This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.. 
+PF15478 Family of unknown function with LKAAEAR motif<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 119 and 235 amino acids in length. There is a conserved LKAAEAR sequence motif.. 
+PF15479 Domain of unknown function (DUF4639)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.. 
+PF15480 Domain of unknown function (DUF4640)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 306 amino acids in length.. 
+PF15481 Chondroitin proteoglycan 4<br>CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification  . The family is rich in conserved cysteines.. 
+PF15482 Coiled-coil domain-containing glutamate-rich protein family 1<br>This is a family of coiled-coil family proteins found in eukaryotes. Proteins in this family are typically between 160 and 397 amino acids in length.. 
+PF15483 Domain of unknown function (DUF4641)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.. 
+PF15484 Domain of unknown function (DUF4642)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 196 amino acids in length.. 
+PF15485 Domain of unknown function (DUF4643)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.. 
+PF15486 Domain of unknown function (DUF4644)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 191 amino acids in length.. 
+PF15487 FAM220 family<br>This protein family is a domain of unknown function which is found in eukaryotes. Proteins in this family are typically between 217 and 277 amino acids in length. There are two completely conserved residues (S and L) that may be functionally important.. 
+PF15488 Domain of unknown function (DUF4645)<br>This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.. 
+PF15489 CST, telomere maintenance, complex subunit CTC1<br>Pfam-B_19246 (release 26.0). CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. Mutations in human CTC1 have been recognised as contributing to cerebroretinal microangiopathy.. 
+PF15490 Telomere-capping, CST complex subunit<br>Ten1_2 is a family of primarily plant and vertebrate telomere-capping proteins that is evolutionarily related to the mostly fungal family of Ten1, Pfam:PF12658.. 
+PF15491 CST, telomere maintenance, complex subunit CTC1<br>CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. This family largely represents sequences from plants species.. 
+PF15492 Neuroblastoma-amplified sequence, N terminal<br>Nbas_N is an N-terminal family of metazoan sequences. This domain lies at the N-terminal of several WD40-containing proteins. The human protein is over-expressed in neuroblastoma cells  .. 
+PF15493 Domain of unknown function, YrpD<br>JCSG:Target-418961/SP17457A. This family of proteins is found in bacteria. Proteins in this family are typically between 236 and 351 amino acids in length. The member from Bacillus subtilis, UniProtKB:O05411, is named YrpD.. 
+PF15494 Scavenger receptor cysteine-rich domain<br>SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.. 
+PF15495 Major fimbrial subunit protein type IV, Fimbrillin, C-terminal<br>JCSG:Target-417041/SP13489F. Fimbrillin_C is a C-terminal family of major fimbrial subunit protein type IV proteins largely from Bacillus species. The family is associated with family P_gingi_FimA, Pfam:PF06321.. 
+PF15496 Domain of unknown function (DUF4646)<br>Pfam-B_61885 (release 26.0). This is a family of proteins largely from fungi.  The function is not known.. 
+PF15497 snRNA-activating protein complex subunit 19, SNAPc subunit 19<br>Eberhardt RY, Coggill P, Hetherington K. SNAPc19 is a family of proteins found in eukaryotes. It is one of the five core components of the snRNA-activating protein complex or SNAPc that helps direct the nucleation of RNA polymerases II and III. The core RNA polymerase II snRNA promoters consist of a single essential element, the proximal sequence element (PSE), whereas the core RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. The SNAPc binds to the PSE of both of these. SNAPc recognises the PSE sequence common to all human snRNA genes, irrespective of polymerase specificity. SNAPc is also known as the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAP19 and SNAP45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAP190, SNAP43 and SNAP50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialised regulatory roles for snRNA gene transcription  .. 
+PF15498 Nephrin and CD2AP-binding protein, Dendrin<br>Eberhardt RY, Coggill P, Hetherington K. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.. 
+PF15499 Ubiquitin-specific peptidase-like, SUMO isopeptidase<br>Rawlings N, Coggill P. Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes.  Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalise with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology.. 
+PF15500 Putative RNase-like toxin<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and conserved cysteine, . 
+PF15501 Nuclear protein MDM1<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is present in the nucleus  . The function of MDM1 is not known.. 
+PF15502 M-phase-specific PLK1-interacting protein<br>Eberhardt RY, Coggill P,. 
+PF15503 PPP1R35;<br>Protein phosphatase 1 regulatory subunit 35 C-terminus. Eberhardt RY, Coggill P,. This is the C-terminus of protein phosphatase 1 regulatory subunit 35. This protein interacts with and inhibits the serine/threonine-protein phosphatase PPP1CA  .. 
+PF15504 Domain of unknown function (DUF4647)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 282 and 480 amino acids in length.. 
+PF15505 Domain of unknown function (DUF4648)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 207 amino acids in length.. 
+PF15506 OCC1 family<br>Eberhardt RY, Coggill P. The human member of this family, overexpressed in colon carcinoma 1 protein (Swiss:Q8TAD7) has been shown to be overexpressed in several colon carcinomas  .. 
+PF15507 Domain of unknown function (DUF4649)<br>Pfam-B_83 (release 26.0). This family of Firmicute sequences has members that are annotated as ribose-phosphate pyrophosphokinase; however there is no evidence for this attribution. Member proteins are all shorter than 100 residues in length.. 
+PF15508 beta subunit of N-acylethanolamine-hydrolyzing acid amidase<br>De Vivo M, Coggill P. NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, Pfam:PF02275.. 
+PF15509 Domain of unknown function (DUF4650)<br>Pfam-B_31507 (release 26.0). This family of vertebrate proteins lies to the C-terminus of Ubiquitin-specific peptidase-like protein family peptidase_C98, Pfam:PF15499. It might be acting as the exosite for the peptidase.. 
+PF15510 Centromere kinetochore component W<br>Pfam-B_49340 (release 26.0). CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.. 
+PF15511 Centromere kinetochore component CENP-T<br>Pfam-B_9162 (release 26.0). CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore.  Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure.  The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.. 
+PF15512 Chromatin assembly factor complex 1 subunit p60, C-terminal<br>Pfam-B_74766 (release 26.0). CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family Pfam:PF12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, Pfam:PF00400.. 
+PF15513 Domain of unknown function (DUF4651)<br>JCSG target SP18156A . family of short, secreted proteins specific to the Streptococcus genus, with distant homologs, not recognized by this HMM, found in other cocci. In all sequenced genomes, proteins from  this family appear in a conserved genomic context with an thioredoxin, tRNA synthase and tRNA binding protein, but the functional implication of this is unclear. 
+PF15514 Restriction endonuclease ThaI<br>This family of restriction endonucleases belongs to the PD-(D/E)XK superfamily. It cuts the recognition site CG^CG leaving blunt ends  .. 
+PF15515 MvaI/BcnI restriction endonuclease family<br>This family of proteins includes the restriction endonucleases MvaI and BcnI. These enzymes both function as monomers. MvaI cleaves the sequence CC/WGG, where W is an A or a T nucleotide, leaving sticky ends. BcnI cleaves the sequence CC/SGG, where S is G or C, leaving sticky ends [1-2].. 
+PF15516 BpuSI N-terminal domain<br>This is the N-terminal (nuclease) domain of the BpuSI restriction endonuclease  .. 
+PF15517 TBP-interacting protein N-terminus<br>This is the N-terminal restriction endonuclease-like domain found in several archaeal TATA-binding protein (TBP)-interacting proteins  .. 
+PF15518 L protein N-terminus<br>This endonuclease domain is found at the N-terminus of many bunyavirus L proteins  .. 
+PF15519 linker between RRM2 and RRM3 domains in RBM39 protein<br>Jackhmmer:Q14498, residues 339-411. A conserved linker between the second and the third RRM domain in human RBM39 (CAPER) protein, also present in other RNA binding proteins, especially those involved in RNA splicing. This linker was implicated in interactions with ESR1 and ESR2. Preliminary results from JCSG suggest that this is a structured domain with a well defined fold.. 
+PF15520 Putative toxin 40<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the type 2 secretion system  .
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+PF15521 Putative toxin 41<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin contains two structural domains, an N-terminal alpha/beta domain and a C-terminal all-beta domain. The domain contains conserved GxR, RxxxoH GxE and GxxH motifs and a conserved histidine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the Photorhabdus virulence cassette (PVC)-type export system  .
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+PF15522 Putative toxin 42<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system  .
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+PF15523 Putative toxin 44<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved [DNE]xxH motif and arginine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, or Photorhabdus virulence cassette (PVC)-type secretion system  .
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+PF15524 Putative toxin 45<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly all-beta fold and a conserved ExD motif and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 7 or TcdB/TcaC-type secretion system  .
. 
+PF15525 Domain of unknown function (DUF4652)<br>JCSG target SP18005A. This family of uncharacterised proteins from Clostridia and Bacilli classes has an unusual structure of three beta propeller repeats that do not form a barrel, as in well known 6-, 7- etc beta propeller barrels, but instead are stacked in a three-layer beta-sheet sandwich. The function of all the proteins from this family is unknown.. 
+PF15526 Putative toxin 46<br>An RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine residues and and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 4, type 5 or type 7 secretion system  . This is also referred to as the E. cloacae CdiAC and has been shown to target tRNAs.
. 
+PF15527 Putative toxin 47<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly beta fold and two conserved histidines, two aspartates and a glutamate residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 5 secretion system  .
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+PF15528 Putative toxin 48<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system  .
. 
+PF15529 Putative toxin 49<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system. Interestingly, the toxin is also found in type-II toxin-antitoxin systems  .
. 
+PF15530 Putative toxin 50<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly all-beta fold and conserved FGPY motif and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 5 secretion system  .
. 
+PF15531 Putative toxin 51<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and conserved aspartate and glutamate residues, and an RxW motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system  .
. 
+PF15532 Putative toxin 53<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and two conserved histidines present in an RxH and THIP motif. The domain additionally has a highly conserved arginine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6 or type 7 secretion system  .
. 
+PF15533 Putative toxin 54<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and [DN]xHxxK and DxxxD motifs. It is usually exported by the Type 2 secretory system  .
. 
+PF15534 Putative toxin 56<br>A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a conserved histidine residue and a KH motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 secretion system  .
. 
+PF15535 Putative toxin 57<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and a conserved glutamate residue, and [KR] and Hx[DH] motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system  .
. 
+PF15536 Putative toxin 58<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved aspartate, arginine, histidine and cysteine residues that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system  .
. 
+PF15537 Putative toxin 59<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 or TcdB/TcaC-type secretion system  . A  of this, the Pseudomonas RhsT-C has been experimentally characterized.
. 
+PF15538 Putative toxin 61<br>A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system  .
. 
+PF15539 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term<br>CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork [1,2].. 
+PF15540 Putative toxin 62<br>A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a two conserved aspartates, a glutamate, a histidine and an arginine residue and an RT motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6 or type 7 secretion system  .
. 
+PF15541 Putative toxin 63<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system  .
. 
+PF15542 Putative toxin 64<br>A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains two conserved histidine, a serine, two lysine, and a threonine residue and a HxVP motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7, and MuF-type secretion system  .
. 
+PF15543 Putative toxin 65<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system  .
. 
+PF15544 Putative toxin 66<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system  .
. 
+PF15545 Putative toxin 67<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and HxR and HxxxH motifs that is usually exported by the type 2 and type 6 secretion system  .
. 
+PF15546 Domain of unknown function (DUF4653)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 229 amino acids in length.. 
+PF15547 Domain of unknown function (DUF4654)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 169 amino acids in length. There is a conserved IDC sequence motif.. 
+PF15548 Domain of unknown function (DUF4655)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.. 
+PF15549 DPPA3;<br>PGC7/Stella/Dppa3 domain . Iyer LM, Aravind L, Eberhardt RY, Coggill P. The domain belongs to a fast evolving family known only from the placental mammals [1-3]. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization  . This suggests that it might bind methylated DNA sequences directly  . The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion  . Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins  .. 
+PF15550 Draxin<br>Eberhardt RY, Coggill P. This family of proteins inhibit Wnt signaling and act as chemorepulsive axon guidance molecules [1-2].. 
+PF15551 Domain of unknown function (DUF4656)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 286 and 398 amino acids in length.. 
+PF15552 Domain of unknown function (DUF4657)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.. 
+PF15553 Testis-expressed protein 19<br>Eberhardt RY, Coggill P. This family of proteins is expressed in testis  .. 
+PF15554 FSIP1 family<br>Eberhardt RY, Coggill P. 
+PF15555 Domain of unknown function (DUF4658)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 161 amino acids in length.. 
+PF15556 ZW10 interactor<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.. 
+PF15557 CAF1 complex subunit p150, region binding to PCNA<br>CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork [1,2].. 
+PF15558 Domain of unknown function (DUF4659)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.. 
+PF15559 Domain of unknown function (DUF4660)<br>Eberhardt RY, Coggill P. This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 189 amino acids in length.. 
+PF15560 Immunity protein 8<br>A predicted immunity protein with an alpha+beta fold and several conserved charged and hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family  . The protein is also found in heterogeneous polyimmunity loci.
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+PF15561 Immunity protein 9<br>A predicted immunity protein with an alpha+beta fold and several conserved polar and hydrophobic residues. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems  . 
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+PF15562 Immunity protein 10<br>A predicted immunity protein with two transmembrane helices, and a WxW motif and a conserved arginine between the two helices. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems  . 
. 
+PF15563 Immunity protein 11<br>A predicted immunity protein with an alpha+beta fold and a conserved HxxRN motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems  . 
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+PF15564 Immunity protein 13<br>A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in heterogeneous polyimmunity loci of polymorphic toxin systems  
. 
+PF15565 Immunity protein 16<br>A predicted immunity protein with a mostly alpha-helical fold and a conserved DxG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-SHH family of HNH/Endonuclease VII fold nucleases  .
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+PF15566 Immunity protein 18<br>A predicted immunity protein with an alpha+beta fold and a conserved histidine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox12 or Ntox37 or Notx 7 families  .
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+PF15567 Immunity protein 19<br>A predicted immunity protein with an alpha+beta fold and a conserved tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a protease domain such as Tox-PL1 and Ntox40. In some instances, it is also fused to a papain-like toxin, ADP-ribosyl glycohydrolase and a S8-like peptidase  . Based on these associations the domain is likely to be a protease inhibitor.
. 
+PF15568 Immunity protein 20<br>A predicted immunity protein with an alpha+beta fold and conserved GR, and GxK motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family of nucleases  .
. 
+PF15569 Immunity protein 21<br>A predicted immunity protein with an alpha+beta fold and conserved phenylalanine and tryptophan residues and a GGD motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox19 family  .
. 
+PF15570 Immunity protein 24<br>A predicted immunity protein with an alpha+beta fold with conserved tryptophan, proline, aspartate, serine and arginine residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-AHH family of HNH/Endonuclease VII fold nucleases  . The gene for this toxin is also found in heterogeneous polyimmunity loci.
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+PF15571 Immunity protein 25<br>A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1, Tox-URI2 or Tox-ParBL1 families  . The gene for this toxin is also found in heterogeneous polyimmunity loci that show variations in structure even between closely related strains.
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+PF15572 Immunity protein 26<br>A predicted immunity protein with an alpha+beta fold and a conserved C-terminal tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-ColE3 family  .
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+PF15573 Immunity protein 27<br>A predicted immunity protein with an alpha+beta fold and a conserved KxGDxxK motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems  .
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+PF15574 Immunity protein 28<br>A predicted immunity protein with an all alpha-helical fold and a conserved HRG motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems  .
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+PF15575 Immunity protein 29<br>A predicted immunity protein with an all alpha-helical fold and a conserved proline residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-REAse-1 or Tox-REase-6 families  .
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+PF15576 Domain of unknown function (DUF4661)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are typically between 281 and 302 amino acids in length.. 
+PF15577 Spc7_C2<br>Spc7_C2 is a short family to the C-terminus of fungal Spc7 proteins. The Ndc80-MIND-Spc7 complex plays a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle  . The N-terminal region of Spc7 co-localises with the mitotic spindle, and it has been argued that Spc7 has the potential to associate with spindle microtubules and that this association is regulated by the C-terminal part of the Spc7 protein [2,3]. However, this family represents only the conserved region towards the end of the C-terminus; the majority of the C-terminal part is in family Spc7, Pfam:PF08317.. 
+PF15578 Domain of unknown function (DUF4662)<br>Eberhardt RY, Coggill P, Hetherington K. This family of proteins is found in eukaryotes. Proteins in this family are approximately 290 amino acids in length.. 
+PF15579 Immunity protein 32<br>A predicted immunity protein with an alpha+beta fold and conserved tryptophan and phenylalanine residues, and a GT motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-REase-5 family  .. 
+PF15580 Immunity protein 33<br>A predicted immunity protein with an alpha+beta fold and a conserved tryptophan, and WE and PGW motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox24 or Ntox10 families  .. 
+PF15581 Immunity protein 35<br>A predicted immunity protein with an alpha+beta fold and YxxxD, WxG, KxxxE motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene  .. 
+PF15582 Immunity protein 40<br>A predicted immunity protein with an alpha+beta fold and a conserved YxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-JAB1 family  . The immunity protein typically contains a signal peptide and a lipobox.. 
+PF15583 Immunity protein 41<br>A predicted immunity protein with an alpha+beta fold and a conserved glutamate residue. The domain is often fused to one or more immunity domains in polyimmunity proteins  . . 
+PF15584 Immunity protein 44<br>A predicted immunity protein with a mostly all-beta fold and GxxE, WxDxRY motifs and a glutamate residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox48 family. This domain is often fused to the Imm71 immunity domain  .. 
+PF15585 Immunity protein 46<br>A predicted immunity protein with an alpha+beta fold and a conserved GxaG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Tox-REase-3 domain  . . 
+PF15586 Immunity protein 47<br>A predicted immunity protein with an alpha+beta fold and a conserved Wea (a: aromatic) motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox7 family  . . 
+PF15587 Immunity protein 48<br>A predicted immunity protein with an alpha+beta fold and a conserved lysine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family  . The protein is also found in heterogeneous polyimmunity loci.. 
+PF15588 Immunity protein 7<br>A predicted immunity protein with a mostly all-beta fold and a conserved arginine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Pput_2613 deaminase domain  . The protein is also found in heterogeneous polyimmunity loci.
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+PF15589 Immunity protein 12<br>A predicted immunity protein with an alpha+beta fold and conserved WxG and YxxxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the NGO1392-family of HNH/Endonuclease VII fold nucleases  . 
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+PF15590 Immunity protein 15<br>A predicted immunity protein with an alpha+beta fold and a conserved aspartate and GGxP motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox10 or Tox-ParB families  .. 
+PF15591 Immunity protein 17<br>A predicted immunity protein with a mostly all-beta fold and a conserved GxS motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox17 or Ntox7 families  .
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+PF15592 Immunity protein 22<br>A predicted immunity protein with an alpha+beta fold and a conserved SF motif and tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox21, Ntox29 or Tox-ART-RSE-like ADP-ribosyltransferase families  .
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+PF15593 Immunity protein 23<br>A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox18 family  .
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+PF15594 Immunity protein 30<br>A predicted immunity protein with an all-beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-HHH or Ntox24 families  .. 
+PF15595 Immunity protein 31<br>A predicted immunity protein with an alpha+beta fold and a conserved tryptophan and Dx[DE] motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-RES or Tox-URI1 families. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems  .. 
+PF15596 Immunity protein 34<br>A predicted immunity protein with a mostly alpha-helical fold and conserved aspartate and cysteine residues and an SE motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the LD-peptidase or Tox-Caspase families  .. 
+PF15597 Immunity protein 36<br>A predicted immunity protein with an alpha+beta fold and a conserved [DE]R motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox13 or Ntox40 families  . In some proteins this domain is fused to the Imm38 -like (PFAM:PF15599) immunity domain.. 
+PF15598 Immunity protein 37<br>A predicted immunity protein with an alpha+beta fold and a conserved arginine. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox40 family  .. 
+PF15599 Immunity protein 38<br>A predicted immunity protein with an alpha+beta fold and a conserved E+G and ExxY motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox40, Tox-CdiAC and Tox-ARC families  . The protein is also found in polyimmunity loci in polymorphic toxin systems.. 
+PF15600 Immunity protein 39<br>A predicted immunity protein with an alpha+beta fold and a conserved DxEA motif and arginine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-ColD family  .. 
+PF15601 Immunity protein 42<br>A predicted immunity protein with an alpha+beta fold and conserved tyrosine and tryptophan residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-REase-10 family  .. 
+PF15602 Immunity protein 43<br>A predicted immunity protein with a mostly alpha-helical fold and conserved arginine and phenylalanine residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox48 family  . This domain is often fused to the Imm72 immunity domain.. 
+PF15603 Immunity protein 45<br>A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-ARC family. This domain is also found in heterogeneous polyimmunity loci  .. 
+PF15604 Putative toxin 43<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a most all-alpha helical fold and a conserved HxxD motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion systems  .
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+PF15605 Putative toxin 52<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all alpha-helical fold and conserved aspartate and glutamate residues, and K[DE] and[DN]HxxE motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5 or type 7 secretion system  .
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+PF15606 Putative toxin 55<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved lysine and cysteine residues, and GNxxD and WxCxH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system  .
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+PF15607 Putative toxin 60<br>A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha-helical fold with conserved DxK, GNxxxG, and DxxxD motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6 or type 7 secretion system  .
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+PF15608 PELOTA RNA binding domain<br>This RNA binding Pelota domain   is at the C terminus of a PRTase family  . These PRTase+Pelota genes are found in the biosynthetic  operon associated with the Ter stress response operon and are  predicted to be involved  in the biosynthesis of a ribo-nucleoside  involved in stress response  . . 
+PF15609 Phosphoribosyl transferase<br>This PRTase family, with C terminal TRSP domain, are related to  OPRTases  , and are predicted to use Orotate as substrate. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response  .. 
+PF15610 PRTase ComF-like<br>This PRTase family is related to the ComF PRTases  . These genes are found in the smaller biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response  .. 
+PF15611 EH_Signature domain<br>This domain with a strongly conserved glutamate at the N-terminus  and a histidine at the C-terminus  , is found in a SWI2/SNF2 four gene operon  . Its strict-neighborhood association with\.     SWI2/SNF2 ATPase strongly suggests a function in conjunction with it  . The other genes in the operon are a OmpA protein and a TM protein  . This has a DNA related function along with the TerY-P triad  .. 
+PF15612 WSTF, HB1, Itc1p, MBD9 motif 1<br>A conserved alpha helical motif that along with the WHIM2 and  WHIM3 motifs, and the DDT domain comprise an alpha helical module  found in diverse eukaryotic chromatin proteins  .Based on the  Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins   .  The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes  . The conserved basic  residue in WHIM1 is involved in packing with the DDT motif. The  module shows a great domain architectural diversity and is often  combined with other modified histone peptide recognizing and  DNA binding domains, some of which discriminate methylated DNA  .   . 
+PF15613 WSTF, HB1, Itc1p, MBD9 motif 2<br>A conserved alpha helical motif that along with the WHIM1 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins  . Based on the Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins   . The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes  . The acidic residue from the GxD signature of WHIM2 is a major determinant of the  interaction between the ISWI and WHIM motifs. The N-terminal portion of the WHIM2 motif also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA  .. 
+PF15614 WSTF, HB1, Itc1p, MBD9 motif 3<br>A conserved alpha helical motif that along with the WHIM1 and WHIM2 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins  . Based on the Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins   . The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes  . WHIM3 along with  WHIM2-N constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA. The module shows a great domain  architectural diversity and is often combined with other modified  histone peptide recognizing and DNA binding domains, some of which  discriminate methylated DNA  .. 
+PF15615 TerB-C domain<br>TerB-C occurs C terminal of TerB in TerB-N containing proteins. This domain displays multiple conserved acidic residues (TerBC)  . The  presence of conserved acidic residues in both TerB-N and TerB-C  suggests that they, like the TerB domain, might also chelate metals. These two domains might also occur together in the same protein independently of TerB  .. 
+PF15616 TerY-C metal binding domain<br>TerY-C is found C terminal to TerY-like vWA domains in some proteins  . It has 8 conserved metal chelating cysteines or  histidines  . It occasionaly occurs as solos  .. 
+PF15617 C-C_Bond_Lyase of the TIM-Barrel fold<br>This family of TIM-Barrel fold C-C bond lyase is related to Citrate -lyase. These genes are found in the biosynthetic operon, with other  enzymatic domains, associated with the Ter  stress response operon  and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response  .. 
+PF15619 Ciliary protein causing Leber congenital amaurosis disease<br>Eberhardt RY, Coggill P, Hetherington K. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localised at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia.  Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.. 
+PF15620 Centromere assembly component CENP-C middle DNMT3B-binding region<br>Pfam-B_64009 (release 26.0). CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability.  This middle region of CENP-C is the binding-domain for DNMT3B. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats.  CENP-C and DNMT3B regulate the histone code in these regions [1,2].. 
+PF15621 Proline-rich submaxillary gland androgen-regulated family<br>Eberhardt RY, Coggill P, Hetherington K. SMR is a family of proteins found in eukaryotes. The family of SMR proteins is expressed in the submaxillary gland. SMR members may play a role in protection or detoxification.. 
+PF15622 Kinetochore assembly subunit CENP-C N-terminal<br>Pfam-B_21609 (release 26.0). CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].. 
+PF15623 Cancer/testis gene family 47<br>Eberhardt RY, Coggill P, Hetherington K. CT47 is a family of proteins found in eukaryotes. Proteins in this family are typically between 262 and 291 amino acids in length. There is a conserved HIL sequence motif. The function of this family is not known.. 
+PF15624 Kinetochore CENP-C fungal homologue, Mif2, N-terminal<br>PB002175 (release 26.0). Mif2_N is a family of fungal proteins homologous to mammalian CENP-C. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].. 
+PF15625 CC2D2A N-terminal C2 domain<br>Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition\. zone of cilia  . This is the first C2 domain of ciliary CC2D2A  proteins which also have another C2 domain (CC2D2AC-C2) and  a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).. 
+PF15626 single CXXC unit<br>This is a solo version of the zf-CXXC domain with a conserved  CXXCXXCX(n)C, zinc-binding motif. This is, thus far,  only detected  in the plant lineage in diverse chromatin proteins  .  Structural  comparisons show that the mono-CXXC is homologous to the structural- zinc binding domain of medium chain dehydrogenases  . The regular  zf-CXXC domain binds nonmethyl-CpG dinucleotides.. 
+PF15627 CEP76 C2 domain<br>Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia  . This is the new C2 domain that is contained by ciliary  CEP76  proteins  .. 
+PF15628 RRM in Demeter<br>This is a predicted RRM-fold domain present at the C-terminus of  Demeter-like glycoslyases  . These proteins  are involved in  DNA demethylation in plants where they catalyze removal of the 5mC  base and subsequently cleave the backbone through lyase activity.  Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic  domain with ssDNA or regulatory RNA  .. 
+PF15629 Permuted single zf-CXXC unit <br>This is a permuted version of a single unit of the zf-CXXC domain  that is detected in the Demeter-like proteins of land plants.  Structural comparisons show that the mono-CXXC is homologous to  the structural-zinc binding domain of medium chain dehydrogenases   . The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.. 
+PF15630 Kinetochore component CENP-S<br>CENP-S is a family of vertebral and fungal kinetochore component proteins. CENP-S complexes with CENP-X to form a stable CENP-T-W-S-X heterotetramer.. 
+PF15631 NTF2 fold immunity protein<br>A predicted immunity protein of the NTF2 fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-NucA family  . This domain is also fused to ankyrin repeats and the PFAM:PF14025.. 
+PF15632 ATP-grasp in the biosynthetic pathway with Ter operon<br>This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo-nucleoside involved in stress response  . In press. Mol. BioSyst. 2012, DOI:10.1039/C2MB25239B. "Ter-dependent stress response systems: novel pathways related to  metal sensing, production of a nucleoside-like metabolite, and  DNA-processing" Anantharaman V, Iyer LM, Aravind L;. 
+PF15633 HYD1 signature containing ADP-ribosyltransferase<br>A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and aspartate residues that comprise the active site. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, or type 7 secretion system  .. 
+PF15634 HYE1 signature containing ADP-ribosyltransferase<br>A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and glutamate residues that comprise the active site  .. 
+PF15635 GHH signature containing HNH/Endo VII superfamily nuclease toxin  2<br>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic s[AGP]HH signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type secretion system  .. 
+PF15636 GHH signature containing HNH/Endo VII superfamily nuclease toxin<br>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive  of this domain at their C-terminus  .. 
+PF15637 HNH/Endo VII superfamily nuclease toxin with a HHH motif<br>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteristic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system  .. 
+PF15638 Metallopeptidase toxin 2<br>A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems  .. 
+PF15639 Metallopeptidase toxin 3<br>A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems  .. 
+PF15640 Metallopeptidase toxin 4<br>A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems  .. 
+PF15641 Metallopeptidase toxin 5<br>A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems  .. 
+PF15642 Toxin in Odyssella and Amoebophilus<br>A predicted all-alpha fold toxin present in bacterial polymorphic toxin systems of the endosymbionts Odyssella and Amoebophilus  .. 
+PF15643 Papain fold toxin 2<br>A papain fold toxin domain found in bacterial polymorphic toxin systems  . . 
+PF15644 Papain fold toxin 1<br>A papain fold toxin domain found in bacterial polymorphic toxin systems. In these systems they might function either as a releasing peptidase or toxin  .. 
+PF15645 Dermonecrotoxin of the Papain-like fold<br>A papain fold toxin domain found in bacterial polymorphic toxin systems  . . 
+PF15646 Restriction endonuclease fold toxin 2<br>A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 7 or PrsW-peptidase dependent secretion system  .. 
+PF15647 Restriction endonuclease fold toxin 3<br>A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or PrsW-peptidase dependent secretion system  .. 
+PF15648 Restriction endonuclease fold toxin 5<br>A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or PrsW-peptidase dependent secretion system. Versions of this domain are also found in caudoviruses  .. 
+PF15649 Restriction endonuclease fold toxin 7<br>A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or type 7 secretion system  .. 
+PF15650 Restriction endonuclease fold toxin 9<br>A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system  .. 
+PF15651 Salivary glad secreted protein domain toxin<br>An alpha+beta fold domain with four conserved cysteine residues and a conserved [DE}xx[ND] motif. This domain is mainly present at the c-terminus of RHS repeats containing proteins in insects and crustaceans. Although no bacterial homologs have been identified, the domain architecture suggests an origin from bacterial polymorphic toxin systems  . . 
+PF15652 HNH/Endo VII superfamily toxin with a SHH signature<br>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6 or type 7 secretion system  .. 
+PF15653 URI fold toxin 2<br>A predicted toxin of the URI nuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system  .. 
+PF15654 Toxin with a conserved tryptophan and TIP tripeptide motif<br>A predicted toxin domain with two membrane spanning alpha helices and RxxR, Wx[ST]IP motifs. The domain is present in bacterial polymorphic toxin systems. The toxin is usually exported by the type 2 or Photorhabdus virulence cassette (PVC)-type secretion system  .. 
+PF15655 NTF2 fold immunity protein<br>A predicted immunity protein of the NTF2 fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-JAB-2 family  .. 
+PF15656 Toxin with a H, D/N and C signature<br>A predicted alpha/beta fold peptidase domain with a strongly conserved triad of a histidine, aspartate/asparagine and cysteine residues that are predicted to comprise the active site of the predicted peptidase. Proteins bearing this predicted toxin domain are particularly common in both intracellular and extracellular pathogens  .. 
+PF15657 HNH/Endo VII superfamily nuclease toxins<br>A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic conserved [ED]H motif and two histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system  .. 
+PF15658 Latrotoxin C-terminal domain<br>A toxin domain present in arthropod alphaproteobacterial, gammaproteobacterial endosymbionts and also at the C-termini of the latrotoxins of the black widow spider. The domain is characterized by a conserved, hydrophobic helix and is predicted to associate with the cell membrane  .. 
+PF15659 JAB-like toxin  1<br>
+PF15660 Immunity protein 49<br>
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/pfamA.txt
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/pfamA.txt	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,14831 @@
+1	PF00389	2-Hacid_dh	2-Hacid_DH; 	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family represents the largest portion of the catalytic domain  of 2-hydroxyacid dehydrogenases as the NAD binding domain is  inserted within the structural domain.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null --hand HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.50	0.71	-4.69	98	16860	2012-10-02 14:31:05	2003-04-07 12:59:11	25	50	4524	180	4691	12854	6366	308.20	17	85.12	CHANGED	lllhp....sh..pptshphlcc.........plphtp....shsp-..clhcthps..s-ulhstsps.....plspcll.pth..spLKlluptusGhDslDlcsAsc+GIhVsNsPs.ssspulAEhsluhllulsRclspspppl+pGpapppthhshphtspshsllGhsthGttssthtpthththhhhshhhs.pttpttthhhht.thhh...................psspllshps.tshppthhhtpptttthhsshhlsssttsshhststhtshtpptthsssshssppp.sshtp.LhshsNVllTPHluus..TpEAppshutpsspslhphhpG....psstssVs	.......................................................................................h.t.hpt..............h..pl.phhp.............hspp....ph..h....p...t..l...t.s...........s..-..s.l.h..s.p.st.s...........l..s.p..c..ll...pth............spL+..hl.u....p....h.u...s.G....h....-....s..l....D....l.s.s....A...p.c..........p...........G...........IhV............s........N.s......P.s......s...s..s....p......u.....V....A..EhsluhlLshsRplspsppph+pGpapttshhshthtstphtslshsthsthhtthtpthththhhh.hh.ttttttttthh..t..h..........................................................................................................................................................tst.hh.htshts.ppthhhspphhthhhsshhlhssttsshhppshhtshhpttthsssshss.tptsshtpsLhphsNVllTPHluus..T.tE.up.pp.hs.p...t.s.hpslh.p.hh.ps......t....p.l..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1361	2755	3878
+2	PF00198	2-oxoacid_dh		2-oxoacid dehydrogenases acyltransferase (catalytic domain)	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.	23.00	23.00	23.10	23.50	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.30	0.70	-5.09	100	10039	2012-10-02 12:01:53	2003-04-07 12:59:11	18	49	3997	65	2920	7770	5825	224.80	35	47.20	CHANGED	ssstpplPlsshR+slAcphspStp.shPphshs...s-l-hspLhplRp.p..................lppph..tt........KlohhshllKAsuhALccaPhlNush..s..s-s.....llhpcplslGlAVsos.....pG..LlVPVl+sscptulhplupclpcLsp+ARss+.Lpss-hpG.GTFTlSNlGsh.G.sphhoPIIN..PpsAILulGpl.pcpP.ls.tssp.........lshpph.....hsloLohDHRllDGAsuucFlppl+.chLE..sPttll.l	.......................................................t....ppl.h.stlR+tlApphhcuhp.ss.s..p...lThh...s-lDhst...lhshRp.p.......................................hpp.t.htcpps..............KLohhsahsKA.lstAL..+..c.a.P.tlNuuh.........s...............scs........llh+ph...hs..lG.......lAV..s...T..s............pG.....L.lV..P...V.l+..ss...-.p.h.ultpls.p.........c.l...pcLup....+.......AR.cG...K..Ls.....s...p-h..pG...GTFTI....oNhG...s........h....G..uh..h..T.PI....l.Ns..Pps.A.I.L.G.luph..tp+......P.ls....hssp................................lshcsh...h.LuLSaDHRllDGtpuu.pFLspl+.phLE..sPtthl.............................	0	940	1801	2459
+3	PF04029	2-ph_phosp		2-phosphosulpholactate phosphatase	Kerrison ND, Finn RD	anon	COG2045	Family	Thought to catalyse 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor.  Involved in the second step of coenzyme M biosynthesis.  Inhibited by vanadate in Methanococcus jannaschii.  Also known as the ComB family [1].	21.70	21.70	24.00	23.70	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.39	0.70	-5.40	61	532	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	495	17	238	524	260	226.60	27	93.52	CHANGED	plplhhsscth.tt........pssVVIDVLRAToTIssALpsGAc.tlhPsssl--Ahthtpt......cshLluGE.RsGh+ltGFDhGNSPh-hp......tppl.....p.GKpllhoTTNGT+Alpcsp.sAp..pllhuuhlNtpAVschltpt.....scs...lhlVsuGhp.GpaolEDhlsAGhlhptLhpptt...........thsDtshsAhtlapp......ttshhphlppusHup+LtpLGh....pcDlca.CsphDhhslVPhh..psGhlhtt	.............................h.....................spsslVlDVLRAooslssAlssGAp.....pl.hss..t.sh..-.c.Ahthtpp.............pshllsGE..Rsu..h..pl.p.......GFDh.uNSPhphp...................t..ptl.......p..G.+p.llhoTTNG.Tpu.lppst...pu..p....plls.u.uhhNspAlAchltpt.......scs..............lhllsuG..p..c.........G..........p...........h...........ul...............EDhlsAGhlhptLtpptt..............................hsDtuhsAhthapp...............ttshh.p.hlp..p.uspupcLhp.h.Gh........pcDlph..Cs.ph.chhshVPhh..ptt....th......................................................	0	95	178	222
+4	PF03171	2OG-FeII_Oxy		2OG-Fe(II) oxygenase superfamily	Aravind L	anon	Aravind L	Domain	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].  This family includes the C-terminal of prolyl 4-hydroxylase  alpha subunit.  The holoenzyme has the activity EC:1.14.11.2  catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2.  The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site [3]. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.51	0.72	-3.71	138	7390	2012-10-10 13:59:34	2003-04-07 12:59:11	15	72	1609	66	3461	10006	2827	101.90	28	28.36	CHANGED	sspthplspYs...................thshuhssHsDs...................shlTllhp...........psuGLplhpps.....................thhsssshss..uhllshG-.h.hhossthpushH+lhssp...............tpsRhShshFhps	..................................................................s...hpl.tYP.h.........................................psphshG.h...s.s.....Ho.Dh........................................................shl.TlLhp.......................................sps.uGLQ..l..hpps.............................................................pWls.l.s.s.h.s......s.....u.......hllN.l.G.......Dh..h.....p............h...h.......o.....N.....u.....t..h......c......S....s...h...HRVhsst....................................ttsRh.SlshFhp........................................................	0	752	2020	2858
+5	PF01073	3Beta_HSD		3-beta hydroxysteroid dehydrogenase/isomerase family	Finn RD, Bateman A	anon	Pfam-B_504 (release 3.0)	Family	The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene  isomerase (3 beta-HSD) catalyses the oxidation and isomerisation  of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene  steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.68	0.70	-5.70	12	1802	2012-10-10 17:06:42	2003-04-07 12:59:11	14	22	886	0	831	37083	19903	231.50	24	68.31	CHANGED	lVTGGuGFlGppIlphLlptc..ltElRlhD......hthssph.p.chtphpst....hlpGDlpDtpplcpAhpGsslVIHTAullDlhG.....hhpppplhcVNlpGTpsll-AChpsuVphhlYTSShpVlGPN.hucslhsGcEppsapss..apcsYspSKthAEchVLtANG..h+sGu.phhTCALRP.hIaGcGsphlhstl.pshcps.hhhthuptpsh.s.VYVsNlAWuHlLAA+sLpss......tstltGphYalsDsoPpppYt-hshplh+shGhchss.h....hPh	.......................................................................................hVTGus..G...F..l...G.......t..p...l..l.......p..t.L.....l...p......p......s.............................h..........p....l......p.....s.....h....c.......................................h..t........t..............t................................................t..........t..h..t.....................hh.p...u...D.......l.......p.........s...............p.........t.......l.........t...........p..............A..........h...............p...............s...............s...............c...........s.............V.......h.......H.......s..........A...........u.............s...........h...h.s............................s...t.....p...........h.......h....p...s.....N.....l.......p....G.......T.....p..s...l.....l........c..............A.........s............t............p...............s..............s................V..............p.............p.......l..........V.........a........T...S...o......h..........s......s............l...........h.............s..................................................t...........p...........s............l.........h..............s.........s................s...............E.............p..........h........s........h................................h.........s..........h........Y........s.....p......o...K....h....h........A..E.......p....h....l........h.........t.........t.........s.....t.............................................................t...........................h....h.....o..s..s.....l...R........P...h........h..I........a..........G.......................s...........p...........p........................h........h..........s..........t............h.......h........p........h..........h.......p.........t............t........................h..........h.......h.......h.......s.........................p............................h......s..........h.....s....a........l...............t......N...l..s........h......H...l..........h.........A....h..........p....t......h...............................................G.....p.................a........h.....s.........t.................h..............................h........................................................................................................................................................................................................	0	251	444	652
+6	PF04419	4F5		4F5 protein family	Bateman A, Wood V	anon	Wood V	Family	Members of this family are short proteins that are rich in aspartate, glutamate, lysine and arginine. Although the function of these proteins is unknown, they are found to be ubiquitously expressed [1].	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  --amino -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-7.95	0.72	-3.22	40	536	2012-10-03 11:22:52	2003-04-07 12:59:11	9	10	268	1	333	500	2	37.30	34	47.06	CHANGED	MuRGsQ+ptsRc+stKKptt.t......spsspsphpssp+t..p	.....MuRGsQ+chuRpKNtKKpsp.t......t+ptp-thsssp+t..p..............................	0	100	162	256
+7	PF03061	4HBT		Thioesterase superfamily	Bateman A	anon	Pfam-B_2758 (release 6.4)	Domain	This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the  biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA  thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other  long chain fatty acyl-CoA thioesters.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.14	0.72	-3.85	140	18406	2012-10-02 20:54:35	2003-04-07 12:59:11	17	57	4420	294	5240	15763	6423	79.30	17	47.56	CHANGED	hGhlaGGsh....hshh-pusshhhtphstt..............hsssshphslsahcs.sphup.hlpspuplhchG+sshhhphclhspssthhs	.................................................GhlaGGhh......h.s.h.h.-.....p.ss.u....h...s...s.t..phstt.................................................tsss.shph........s.lsa..hc...s..s..p..h..........u........p...h.....l.....ps......pu.....p.....l..h......c..h.....G..p..p.sh..hhphclhsppt....h..........................................	1	1455	3083	4266
+8	PF02872	5_nucleotid_C	5_nucleotidaseC; 	5'-nucleotidase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1318 (release 3.0)	Domain	\N	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.11	0.71	-4.25	119	7487	2009-01-15 18:05:59	2003-04-07 12:59:11	13	118	3115	27	1573	5671	648	166.60	21	29.23	CHANGED	slu.......psth.......................t.sh....tp-ss....luslls-uh................tttsss...............c.............lulhss.G.sl........Rs..s........................tG.s...lTht-lh.slhPFs.Np........lhshplsGp.plpphLE...........................tsssthh............phu.........G.lch.ph.Dhsps.................upRlssl..................sup....sl..-sspp..Yplssss.......a.hs....sGucs..a..h......htp	...............................................................................................th........htpss.....hspllssA......................tth.s.ps........................s...................luhh...ss..G..sl..........................Rs..sh..............................tG..s........lThp...slh..sl....hP....as...Ns..............l.ssh.c.loGp.p.l.+..ch.LE..........................................psthh...................................................plh.......G..lpa...p.h....chs.ps.............................................up.R..ltsl.................................................pGc.................sl......-....s..s...pp....Yplusss.............a..hu...........s.G.Gst...a......h...................................................	0	507	918	1282
+9	PF00003	7tm_3		7 transmembrane sweet-taste receptor of 3 GCPR	Sonnhammer ELL	anon	Prosite	Family	This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G Pfam:PF07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor Pfam:PF01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness [1].	25.80	25.80	25.80	26.30	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.91	0.70	-5.02	109	4297	2009-09-14 23:22:24	2003-04-07 12:59:11	17	59	213	0	2615	3557	7	227.40	29	32.05	CHANGED	hGhhh.slhlh...........slFhpappTPlV+usst.pLsallLhulhlsahsshhal.ucPs................shs.........Chl+phhhulsFslshSslLsKohp.lhh..........hFc..tst..stt..hhh......................sttphhhlhhhshl.Q..lllsslWls..hsPP..................................ht.......sht..tptp.llltC.........p..s.sshshh.............hhLuYhshLhllshhhAa........................hsRclP...csFNEAKaIsFoMhlhshlWlsFlP.hahss......pu.p.....................................apssl.shullhSuhuhLhslFhPKsalI	..............................................................................................hhhh..shhlh...........hlFl.....p.a..p..s.T...Pl.V+...Asst...pLsallLhulhls.ahs.........s.hh...a.l....u.c.P.s.......................................hs........................C......h.lRph...h.hGlsFslsh..S.....slLsKThp..lhh.................................................h.Fc.....tsp..s.tp....hhp.............................................stt.hhl...lh.hhshl.Q...............ll....lsshWls.......hsPP.......h.............................................................pt............shp....sp.tp....ll...l.....p...C..................p...p....s.oshuh..h....................................ssL.G..Y.h.slLh.l.h.s.hhhAa........................hsRplP...-sF.NEAK..a..I.sFo..M...............hs..h..s....h.l..W....l.sF..l...P...h...ah.s.o...pu.p.....................................hh.s..s..s.h...hu..ll.hSu..h.sh.Lss...lFhPKsall.........................................................................	0	448	660	1746
+11	PF01661	Macro	DUF27;A1pp; 	Macro domain	Bateman A, Mistry J, Wood V	anon	Pfam-B_434 (release 4.1)	Domain	This domain is an ADP-ribose binding module.  It is found in a number of otherwise unrelated proteins.  It is found at the C-terminus of the macro-H2A histone protein Swiss:Q02874. This domain is found in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alphaviruses Swiss:P03317. This domain is also found on its own in a family of proteins from bacteria Swiss:P75918, archaebacteria Swiss:O59182 and eukaryotes Swiss:Q17432.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.40	0.71	-4.19	124	5297	2012-10-02 00:07:53	2003-04-07 12:59:11	16	119	2806	93	1542	4535	236	112.30	29	10.96	CHANGED	VNAANssLhs.....GGG.VsuAI++tuG.spltpts.pph......tt......stsGpAhlTsuhpLs......s+aVIHs..VG..Phap.....spppptchLtssYcssLpl........s..pcpslc.....................olAhPsISoGlaGaPh-cusplh	..........................................................VNAANsp.h.h.t.........G.uG..V.s..sAI.........pct..u..G..sp.l..t..p.t.s....pp..h............s...........................h.s.Gp...A..h.l..T...p...u..h..s.Ls...............s+hlI..Hs..VG...Ph.hp...................spppptphL...ts..sY...cssLph..............s..pp.p.s.hp...................................................................olAh.....P.s.I.SoGl..a.uhPhppusph.....................................................................................................................	0	543	862	1216
+12	PF02177	APP_N	A4_EXTRA;	Amyloid A4 N-terminal heparin-binding	SMART	anon	Alignment kindly provided by SMART	Domain	This N-terminal domain of APP, amyloid precursor protein, is the heparin-binding domain of the protein. this region is also responsible for stimulation of neurite outgrowth. The structure reveals both a highly charged basic surface that may interact with glycosaminoglycans in the brain and an abutting hydrophobic surface that is proposed to play an important functional role such as in dimerisation or ligand-binding. Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggest the APP N-terminal domain could function as a growth factor in vivo [1].	22.10	21.60	22.10	31.90	19.70	21.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.61	0.72	-4.10	15	356	2009-01-15 18:05:59	2003-04-07 12:59:11	11	16	88	12	114	317	3	98.20	60	14.97	CHANGED	a-P.........pVAhhCG+hshahs...hpsGpWhsDssst...tsChpscp.-ILcYC+KlYPchsITNlVEuu.p.VpIssWCchsp...spC+s....sHhVpPYRCLsGcFhS-ALLVP-	............A.EPQlAMFC.G+LN....MHhN...........lQsGKWEsDPoGT...KoCltoKE.tlLQ.YCQE.hY..PELQITNVVEAN....QP..VoIpNWC++u+....KpCKs.....HhVlPa+CLVGEFVSDALLVP-...............................	0	20	28	61
+13	PF00962	A_deaminase		Adenosine/AMP deaminase	Bateman A	anon	Sarah Teichmann	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.85	0.70	-5.52	15	4245	2012-10-03 00:45:34	2003-04-07 12:59:11	17	22	2418	67	1678	3809	1081	319.30	23	76.53	CHANGED	sl.Ks-hHlHtsushs.cpLLchh+pphht..stssh.p.tphlphtps.csLphhhhshslsshsl+.t........................................................................................h.hhpssRhhsh.ptcchhtstsphlEshapPhhps..........shssp.hsthclhpthlsGhDps-cEst..hss+hhhsch.p.....sppaspph...scshshYh.h..hhsshslhs................phppptthsslhhpsHuGEsushpplhsAhhh....htuccIuHGltltccPhL.thht.p...........QIslphsPlSNssLthhtshccpPlhpahccGlsVSLuTDDPhhFphT...LhcEYslAspsa...thop..s-hsclA+NSlhtSuhscctKpchLuc	........................................................................................................................................................................................h.t.s-lHhH....lsGslp....phl...hc.l..sp....p..t..t...........h.....t..............................................h.........p..........h.......h....h.....p.........h....h.....t....t...........t.......s....L..............p...a........h....p..h..h..s..h.s.h.tslt..............................................................................................................................................p.ps.hp.t.hs.h.t....h.h.p.c.h....t.....p...s...s.ltahElh...a.s.P.....hhs....................................pts.........h....s...h...t......t......s...l..p...s....l.......h.p..u..h...c......p....u.......p...c...p.hs..............lps.p.h.....l.....h.s..h...Rp..............stph...s...p....ph................hp...hh....h...t...a....t....p............hlsul.sl..s..u.s.E...s....h.sst................ahp.h..h..p..p...s....p.p.t.......s..h..t..hssHA.......G..E........s........s........s........s........p........p...l..h..p...Alth.........................hts.c..R..I.uH....Gl.....p.....h......h.....c..........c.......................t..........L.....h......p..h...l...h..p..p........................................pIs..l...Eh....CPh.....S..Nh.p............h...........t..h...............h..............t....s.......h.............t....p........H........P....l.....t.......p.....h...........h.........p.........t.G.........l.....................s........o...lsoD.DPsh........sss.....................l.cEat.hs.t.....pth....shs.........pp...ht.p.h................s.h.Nul..phua.hst..p.p.Kpthh.........................................................................................................	0	516	944	1371
+14	PF01490	Aa_trans		Transmembrane amino acid transporter protein	Bashton M, Bateman A	anon	Pfam-B_419 (release 4.0)	Family	This transmembrane region is found in many amino acid transporters  including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane  domains Swiss:P34579 [1]. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance Swiss:P38680. Other members of this family include proline transporters and amino acid permeases.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.16	0.70	-5.99	24	6390	2012-10-03 01:44:59	2003-04-07 12:59:11	13	58	501	0	4195	7221	166	337.70	15	78.72	CHANGED	pssoshpushpllsuhlGsGlLuLPaA.hpphGhlsGlhhllhhuhlohaohhlLspshph.........tppttoYt-ls...........tphhGsth.hhlhshs.hlp.lGhsluYhlhsupsl.slhpshh....tt.......h.h..ppshahhlhshlhhsLo.hlsshstLuhhSlluslhhhh.....................hshlhhhhhshshhsshshshhsh........thphhphhhulGslsFAasspshlhsIpssh+s.Ppp........cshhhuhhhsslhahhhGhhGYhsFGsssts..sllhshs.p......hhshsplhlsltllhuhsl.hhPlhphl-phlh...................................................................................s.hps.hhthh...chhhRshlVlhohhlA.lhhPhhstllullGuhushsloalhPshhahphhtsphhshphhhh...hthhhhhhulhhhhhushshlh	........................................................................................................................................................................t...t...shh.hhp..........sh.....l..Gs.G.l...L.u..h...P.....h...u....h.t..................p.........h......G.....h.....h.................u..h.....h....h..h..h.........h...h...u..h.hs..h....a.s....h.h.l.l....h.....p.s.h....................................t....h..sa...t..phs.......................................................thh.h..G.....hh....th....hh.t....h..h.h........h...h........h.......s.h..............sh.s....ah....lh....h.u.p..h....t...h..h..t.....t..........................................................h...p...h....h....h..h.....h...h...h..h..h.h...h...h...s....h.......s.....h......h.....t.....p...h...p..........l....t..h....h.u..h....h.uhh.hhh.h...........................................................hhh...h..h..h...h..h....................h......................t.h...........................................t.............t....h......h.....s....h....s...h....h...h.....a........u......a.............................s...p.......................h...h...l.................s....p....h...............p...............p....s......pp..........................ts.......h....h......h..s.....hh.......h...s..h.h.h.....a.....h..h...........h.........u.h...h...u.............Y............h....t.....a.........G......s..........t......s....t...s...............s.....l.hh.s..h.s..............................h.h.h...s.......h....h...h....h...h....t.h...h.h...s.....h....s........l.......h....h.........s..h...h..t...h...l...t.hhh.......................................................................................................................................................................................................................................t.........h.......h.h...........hh.h.h..p..h...h..h..h....h..h...s............hh...lu....h....h...h..P.........h..s...........l....h...........u...h..h..............G.uh...h..ss................hsh...h.......hP..s.h..h...hh.......h...........h..h......................t..........................................................h.............................................................h..h.h..h..h.h..s.hh....h........h..............................................................................................................................................................................................	2	1380	2401	3501
+15	PF00004	AAA		ATPase family associated with various cellular activities (AAA)	Sonnhammer ELL	anon	Prosite	Family	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.75	0.71	-3.95	207	52090	2012-10-05 12:31:07	2003-04-07 12:59:11	24	426	6164	264	20937	92205	29927	130.80	25	20.90	CHANGED	lLLhGPPGsGKThlA+ulAsp...............h.............s....hs.................a.hplsusplh.t................ahGtutppl+plapp.A....cpts........s.sllFlDElDulssp+................t..tppshspLLsthDshpst..........................s.lhlluATNc..s-tl-sALh.h.uRh-phlhhsh	....................................................................................................................................hlLhGP.P..G....s.........G....K.........T....h........l....A....c..........u...l...A...pp...........................h..............................s................tp.......................................................................h...h......p...l....s...s...u....s....h.....h.....pt..............................................................................................................................................................a..h..G......p....h....t....p......c......l......+......p......l.....h..cp....s..........cpps...............................sll...F...l.....D...E....l....c...s...ls.sst.......................................tt.t....t.t...p...s....h.....s....t...L....l......s..t......h...-...s.h.p........................................................................................h...h...h..l.....u...A.....T....st.............p..........l.....s........s.lh.........tR.hph......h...................................................................................................................................................................	0	6957	12667	17600
+16	PF00696	AA_kinase	aakinase; 	Amino acid kinase family	Bateman A, Birney E, Griffiths-Jones SR	anon	Pfam-B_100 (release 2.1)	Family	This family includes kinases that phosphorylate a variety of amino acid substrates, as well as uridylate kinase and carbamate kinase. This family includes: Aspartokinase EC:2.7.2.4, Swiss:P00561. Acetylglutamate kinase EC:2.7.2.8, Swiss:Q07905. Glutamate 5-kinase EC:2.7.2.11, Swiss:P07005. Uridylate kinase EC:2.7.4.-, Swiss:P29464. Carbamate kinase EC:2.7.2.2, Swiss:O96432.	24.90	24.90	25.00	24.90	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.76	0.70	-4.83	135	25691	2009-01-15 18:05:59	2003-04-07 12:59:11	23	74	5328	286	5789	16900	9693	240.60	20	64.39	CHANGED	phh..V.lKlGGssls.st...........t.lp.plspplt......t.......................hhpt........shcl.llVsu...uG.....s....hssthhpt.............t..........................t.h..ptt.................tltp....................httlhst.hpphss.thhshhhps......tsh.shth....................................tptlpphlp..p..s.hlsllsuhh.....ss....ps....th..................sthssDtsAshlAttlpA...c..lhhh..oDVsGlastpP.....su.phlsplshp-htphh......................psGhtshh.tuhpss.pp..s..shplhlhs	.....................................................................................................hlVlKhGGsuls.st......................................p.lp.p.ls...p.p.lt.......p...........................................ht.pt.....................................Gh..cl..llV....pu.....uG........s.....hssthhtt..........................................................................................................t..h.h.h.pt.t.....t..........................................................thtp..................................................hh.s..hlsth.....h......p.t...h...s...s.......hs....h.sh..h.hpp................ts.h...s.t.t.h...hth..........................................t.....hs.tp.tlp.p.h.Lc......p.......s.tls..l.h.suh........ss...............ps...th....................................shhssDpsAu.hlA...t.....t..l....p...A.............D...hlllh........T-V..-.G..l....as.s.s...Pth............s....s....u...p........h...l...s....p..l..s..h..p..-..hhchh..........................................................tG.ht.sh.hts....Ahphs.pp....t.s..h.shhlh..............................................................................	0	1858	3683	4867
+17	PF03109	ABC1		ABC1 family	Bateman A	anon	Pfam-B_339 (release 6.5)	Family	This family includes ABC1 from yeast [1] and AarF from E. coli [2]. These proteins have a nuclear or mitochondrial  subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex [1] and E. coli AarF is required for ubiquinone production [2]. It has been  suggested that members of the ABC1 family are novel chaperonins [1]. These proteins are unrelated to the ABC transporter proteins.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.40	0.71	-4.13	32	5521	2012-10-02 22:05:25	2003-04-07 12:59:11	11	49	2872	0	2412	4867	2734	116.90	31	21.56	CHANGED	ppLG.pshcchFppF-ppPlAuASluQVH+ApLps........GppVAVKVQ+PslppphptDlthhphlsphhpth..t........clttllc-hpcpLhtElDahpEApssc+htcthpch.....shlplPpla	.................................................t.thG.tsh.p.p.hF..s..pF-...t...p.P..lAuASIu......Q..............V..HpAp.L+s.....................................Gc..c....V.sVKVp..+Psltp.................hlpt.Dlpl....l......p...hl.u.......p.h....h....p...t....h.h.st...................hhc.hp...pll.......cEhp..........c.......plh.........pE...........lDhhpEAtNs.pphp...c..p..hp.sp............s.hl..hlPcl........................................................	0	828	1543	2052
+18	PF01842	ACT		ACT domain	Bateman A	anon	Bateman A	Domain	This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.  The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine [1]. Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585	20.80	20.20	20.80	20.20	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.83	0.72	-4.43	180	20885	2012-10-02 00:29:19	2003-04-07 12:59:11	20	130	4518	161	5944	23355	10616	64.10	16	16.98	CHANGED	thlt...l.tst.-c.sGlluclhshlucpslNlpplpttsstt...........thhhhhhhssppshpphhcplcphhs	......................h..l.h..h...Dc.PGllucls.shlu.c..p..slsls.ph.p...psstp......................hthhhhhh...hspt.t.tthht.h.....t.............................................	0	1838	3898	5060
+19	PF04083	Abhydro_lipase	abhydro_lipase; 	Partial alpha/beta-hydrolase lipase region	Wood V, Finn R	anon	Pfam-B_267 (release 7.3);	Family	This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.17	0.72	-4.61	82	1362	2012-10-03 11:45:05	2003-04-07 12:59:11	11	14	288	4	980	1460	9	63.00	36	14.19	CHANGED	sscllppaGYssEpHpVpTcDGYlLslaRIstsp...........................................t.tspPs...VhL.HGLlsSSssWlhss	........................phlptaGYssEpHp.VpTcDGYlLslaRIPpsp.......................................................................................................ttt.ttt+..sVhLp..HGLlssSssWlhp.h...........................................................................	0	284	440	775
+20	PF00583	Acetyltransf_1	Acetyltransf; 	Acetyltransferase (GNAT) family	Bateman A	anon	MRC-LMB Genome group	Family	This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.44	0.72	-3.95	241	50804	2012-10-02 22:59:21	2003-04-07 12:59:11	19	363	5227	314	15580	72453	11235	83.90	18	39.27	CHANGED	hptsspllGhsththhtp................................................ttstltslhVp......ssa+spG.lGptLlpthhchstp..hs.......hpplthts.tts.Ntt...uhphYp.+hGFp	......................................................................................................h...tspllG...h....h..h..h...hh..p.............................................................................ttht.l...t....p..l..h..V.p...................s...p...h...+........s..p..........G....l......G....p......t....L....l........p.....t......h....h.....p..h....upp.....ts..............................h.p..p..l....h....L..t.s.....tt.......p....st............uh..t.hY.p..chGa...................................................	1	4938	9501	12964
+21	PF01648	ACPS		4'-phosphopantetheinyl transferase superfamily	Bateman A	anon	Pfam-B_1679 (release 4.1) & Pfam-B_3672 (Release 7.5)	Family	Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1]. This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known [3], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.84	0.71	-4.27	154	7983	2009-01-15 18:05:59	2003-04-07 12:59:11	15	48	4744	99	1916	5342	1894	110.90	21	48.33	CHANGED	slGlDlEph.....pt................................thtp..lhpph.h...sspEhphltphss....................................thhhthWohKEAhhKuhs....t..................h..hsthphphtss.................................................h..htttttphpht...hphttptthssshs	.....................................................................lGlDltcl......pph..............................ppspp...h..h...c+l...h...os.s.E.h.phhp.shpt...........................................................................h.p.hh.s.thausK.EAhhKAhG......pG.......................................th..hshpp.l.plhps...............................................t..................................................................................................................................................................................	0	622	1194	1612
+22	PF01064	Activin_recp		Activin types I and II receptor domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_338 (release 3.0)	Domain	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich  ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.21	0.72	-11.34	0.72	-3.34	26	942	2012-10-03 01:43:02	2003-04-07 12:59:11	18	17	116	67	464	892	0	83.70	25	16.38	CHANGED	lpCh.Css..........Cs..pss.....ppCps...................suhCasthphspst...hphhpp....GChshppts......hhCps..................sss...spshtCCp.sDaCNcshp..h	........................................................Ch.Cp.......C....pss.........tpCps...................sstCasshpp...sss........hphhpp..........GChstt.tps.................hpCts.............................psps.........spsh.h..C.Cs...s-hCNpph....h.................................................	0	82	118	270
+23	PF00441	Acyl-CoA_dh_1	Acyl-CoA_dh;	Acyl-CoA dehydrogenase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.47	0.71	-4.11	58	26994	2012-10-01 23:33:27	2003-04-07 12:59:11	19	118	3319	208	9422	25135	11877	150.80	24	33.41	CHANGED	spGathshps.lshpRhslustshGhsppsl-pshpascpR..psFG.p.lhshpslpppLAchtsclcus.+hhshpsup...thcpspss........tttsuh.sKhhuschstclsppAhplhGuhGh.......h.pchs..lp+haR-s+shpIht.GosEl.tttllu+phh	..........................................................................................................................spGhthhhp...t..LshsR..l...s........l....u....s....t.....u....l...G..........h....u........p..t......u.....h..c..t.....s.....h..p.....Y...u...p..p....R....................p....p...........F............G......p.............s...............l......s........p......h......p...s..........l..............p......p...p........L.......A.......c...h...t.....s...p..l..p....s.......u.....+.......h.......h.......s......h....p.s.A.t..................th...-...p...upss................................shtsu.h....s........K........h.....h...s....s.....c...t..............u...h........p....s....s..s...p...A.l.Q......l.....h...........G....G.h..Ga..............................h..p-hs..........lt+..h...h.....R....-....s.......+....l....h...p...lhp....G.ospl..p.t...hluc...h................................................................	0	2614	5667	7871
+24	PF01757	Acyl_transf_3	DUF33;	Acyltransferase family	Bashton M, Bateman A	anon	Pfam-B_708 (release 4.2)	Family	This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterised C. elegans proteins and it is approximately 300 amino acids long.	31.00	31.00	31.00	31.00	30.90	30.90	hmmbuild  -o /dev/null --hand HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.29	0.70	-5.61	111	12610	2012-10-02 17:00:17	2003-04-07 12:59:11	17	41	3761	0	3737	10989	1698	328.50	15	74.75	CHANGED	hhtlD.....hlRsluhlhllh.hHshh...hhhh.shhh......................................hhsthslslFhhlS..Gahh...................................hpttshhphhhcRhh+lh....lshlhhshlhhhhthhhhththhthhhhhhhh.............................................................................................................................................hhshhW........alhsh......hhhhllhshh...............hhhhpphtthhhhhhhhhhhhhhhhhhhhhh...................hth..hhh.............................hhhahhGhhhsphttphptthh..............hhhhhhhhshhhhhhhhhhhhhht................................h..hhthhhhhhshhhhhhhshhhtpht.....thh..............hlthlu.phShslYlhH...........hhlhhhhtthhhhh.................................hhhhhhhhhhslhlsh....lhhh	...................................................................h...l-slRuluhlhVlh...hH....hhh...............hh.h.......................................................................................................huh..h..u...V.s..l..FFhl.S..Galhh.................................................................t.tp..h.....s.h..t..p....a...h..h.......+.....Rh.hR.lh................hsh.l.h...h...h.........h..l.....h.........h.........h........h......h.........h......h........h.....h......t......h.....h....h...h....t.....h..t...h.....h.hh.h..............................................................................................................................................................................................................t....h..h..h..p.....h...W.................hLss...........hhha..ll...h..sll............................................hhh.h.....t......p........h....t.......t.........h.........h......h......h.........h......h.......h.........h...h....h......h.....h....h.....s....h...h...h...h...h...h..h..h................................................h....................h..h..........................................................hhha..hhG....h........h......h....s....h....h....h...h...t....h...t...t..t...h........................................................................h.h.h..h.h....h..h..h.....h......h....h.s..h..h..h..h.h.h..h.h.hhhh.....................................................................h..h.....h....h...h....h......h....h.....h.....h..h....s..h....h....h...h...h....h...h.h..h...t.h....p..ht.................hh........................................h.ht.hlu..p.h.S..a.u....l....Y....L..h..H................................h..l...h...h..h..h.t..t..h..h.hth...................................................................hhh.hh.hh.h.h.h.s.hhh.sh....hh..................................................................................................................................................	0	1161	2171	3133
+25	PF00928	Adap_comp_sub		Adaptor complexes medium subunit family	Finn RD, Bateman A, Coggill P	anon	Pfam-B_1007 (release 3.0)	Family	This family also contains members which are coatomer subunits.	20.80	20.80	20.90	20.90	19.80	20.70	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.86	0.70	-5.29	46	2208	2012-10-02 01:13:52	2003-04-07 12:59:11	16	30	497	31	1352	2129	25	258.90	25	54.82	CHANGED	hsh+sss.hp....appNElalDllEc....l.ss.lhsp.sGp...llpu-.lpGplphpshLsG.hPplplulsc.h.............................................sh.l--hpFHtCVphsp.a.cp....................p+hlsFlPPDG..cFpL......hpY...+l.......................................................spp....hthPhpl.hsphp........................................................p.tst.schchhlphctp......htp...sspslhlplPl....Pps......................................ssssshps.stG....pspapsppp...hLhWsI....tclss......p...hp......................................................u.plphssthp...................phss............................lslpFplshhssSul...........................pVchlcl..h..t......pshpsh+hV+YhTpus.paplRh	................................................................................................................................hp.t.s.hp....apps.ElalDllEp....................l.s.........h.l..............hst.....s.....G..p....................llpuc....ltGpl....phps.h..Lo...G...hP..-...lp..lulsst................................................................................................................ttshtl-D..spF..H...CV..chsc..F...-s....................................................c+hl......uF......l.......P.....P.....D......G.....pFp......L...........hp........Y....Rh.........................................................................................................................................................................ssp.........h.l.h.pl..ps.hp.......................................................p....up..s+h-h.hl...p.hctp..........................htp.....hspsV.lpl...P.h....Pps............................................................................ssssp..hps.....s.G................php.aps.ppp....slhWpI.....tphss..........tp.....shp.......................................................................................................u.ph..ph..s.s..t...st.t..........................th.s.........................................................................................................lslpFp.....l....s......h..s...sS.Gl................pV..chlpl....p................tthpsh.h.V+a.spst...h.......................................................................................................	0	456	720	1076
+26	PF00107	ADH_zinc_N	adh_zinc; 	Zinc-binding dehydrogenase	Sonnhammer ELL	anon	Prosite	Family	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.35	0.71	-4.60	108	42002	2012-10-10 17:06:42	2003-04-07 12:59:11	21	474	5352	463	12979	36140	9081	125.70	20	28.57	CHANGED	ulGhhulphA+shG.......spllssstspp+hchAcphG...Astslsspptt......................hhppltchssu.........GsDsll-ssG.ssshppulphlphsGplshlGhss............tshshshhtlhhpphslhGshhss........pphtphlphlhp	.......................................................................ulGhhul.p.h....A.+..t.hG...........scV.l....u....s........s....t...........s.........s......p.........+........h.........c.......h.........A.....c......p...........h.....G..........A......s........p......s....l....s......ppts.................................................hhptl..t..c..h.sss.......................G.s..D...h..s..l...-.....s.......s.....G..........................s............t...........s............h.....p............t.......s.....l.....p...........h.....l........p................s........G.........p......l......s.h.l.G.hss........................t..h...h...s.....h..................h....h........h..p...t..h.p..l.h.....G..h..hht............t...........t...................................................................................	0	3503	7483	10666
+27	PF02682	AHS1	DUF213; 	Allophanate hydrolase subunit 1	Mian N, Bateman A	anon	COG2049	Family	This family is the first subunit of allophanate hydrolase.	20.40	20.40	20.40	21.10	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.08	0.71	-4.85	158	3092	2012-10-02 15:38:38	2003-04-07 12:59:11	11	20	2321	14	753	2183	1289	203.30	32	52.43	CHANGED	h..p.lpshG......-pulllphs.pt.hs.......shtppl....hsltptlppt.......hsulh.-llPuhsolhlpa-.shth............sht..plt....stl....pph.hpp...ttspttsst..............p...........lclPVtYssphG......................DLtpVAchsGLo.hc-VlphHosspYpVhhlG.FtPGFsYLuulstp...L.t.sPRpssPRtplPuGSVuIAGpQoulYPhsSPGGWplIG+Tsh..tlF.Ds.pp.psP...sll	...............................................................chh.hG-pulllc....ht........lsh..........shp.tcl....hsltptLppt................hssll...-l.lPuhs....slhlhac..stt.l..............................shp...slh..ptL..............pph..hpp.............tpshpsss.............................................+h...............lcIPVhYs..s.th...G..........................DLp.VAchsG.Lo...hcpVlchHoss...pY....hVhhlG.FhPGFP....YLsulspp..........L..t.sPRpspPRhtlPuGSVGIuGspoGlYP.hs.oPGGWQlIG+T.s..l...plFcs.pc.p..h.......................	0	200	423	624
+28	PF03915	AIP3		Actin interacting protein 3	Wood V, Griffiths-Jones SR	anon	Pfam-B_38461 (release 7.2)	Family	\N	24.50	24.50	24.80	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.37	0.70	-5.57	18	245	2009-09-10 22:05:34	2003-04-07 12:59:11	8	6	183	3	166	277	0	303.00	27	37.23	CHANGED	FL+lssKsKKshlsh...slo.hspLRLLFlEKFAYSPGss..sFP-IYIpDPpouVpYELE-..Lp.DlK-GolLsLphcp..................c.ssshssLpc.hlcsl+pplscppssl..................hpclpsh.tsssh.hsp.ssuss.....sttspppssstt.ttps..................hpElpslc+-Lull+QhasstpsslpsolsslhpKlssh+s.sulsss.....ssSsRuYh-pupscLu--SDpLls+VDDLQDllEsLRKDVApRGVRPsc+QL-slsK-lppApc-LpcMppaIspEKPhWKKIWEsEL-+VCEEQQFLsLQEDLshDLp-DLcKApETFsLVEQsocEQtKssups................+s+sl..lslscPG.ohpph+DtVLsEVpuLpPsHESRlEAIERAEKLRp+E+chp+sscFpcELusFVEcuKLKKSGGlEElERhR+tKD-	.....................................................................................FLQhtscsK+hhlsp........tlo.hsplphh....FlcpF....shp..t.p....chP..p..IYIpDs..ps.lhaELED......lp.-l+D+olLhL..c................................................................................................................................................................................................................................................tphptlp.-lt.h+p......h.pt..tthtt.htshh.p.h.t.t..htt....s..t..............ttt.hhpttpp.htt.s.tl.tc...lp-LpshlEth+tD....VhpRtsps..ptlcth...ltthptpltphp.hh.t.p..hpphhptEhp.l..sptpp.hp....c.h....th.t.htth.thh..ht...h..................................................................................................................................................................................................	0	57	95	141
+29	PF00842	Ala_racemase_C	Ala_racemase; 	Alanine racemase, C-terminal domain	Bateman A, Finn RD	anon	Pfam-B_1496 (release 2.1)	Domain	\N	25.00	25.00	26.50	25.50	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.61	0.71	-4.73	121	5638	2009-01-15 18:05:59	2003-04-07 12:59:11	16	16	4223	90	1060	3928	1372	125.90	36	32.58	CHANGED	lhs.Lcucllpl+pl.psGps..lGYGtsapspcss.plAslslGYADG..hs.Rthus.ps................l....hlsGpps..Pll....GRlsMDhhhlDlo...........ph...ssp.G........-pVhlhG.tp......hss--lActssTIsYEllsplut.Rl.Rhah	......................shoLpoplltV+pl.p.s..G.-..s..VGYGs.sap..u..pc.cp..pluslslGYAD..G..as.Rph..ss..ts...........................V.......ll.......s....G....p....cs....sll....GRVsMD.hhVDls.......................p.sphG......sp.VhLaG..pp........................lsl--lAph.s.s.TI.sYEl.l.stl.sp..RlsRha.h..........................	0	358	686	893
+30	PF01168	Ala_racemase_N	UPF0001;	Alanine racemase, N-terminal domain	Finn RD	anon	Manual	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.87	0.70	-4.79	613	12691	2012-10-03 05:58:16	2003-04-07 12:59:11	15	33	4649	104	2910	10839	5318	218.10	20	66.44	CHANGED	lsLsslppNlpthppts....s..........ss.lhAVlKusuYutuhhpsut.h..t.u.....s..c.....shulsplpEAl........................tLc....ps..............tl.hh..........ppl..hhp.......slhhslsshcth.p.tlsptttt................tpslplhlpl-o.Ghp........RhG.........hs..s........pth.........phhp...tlp...........s.....lplpGlhoHhus.u............-....p.t........tpp.p.hpph....pphhptl........t.....t...............hhshusSushhht.........h......p...hsh.VRsGhslaGh...ps	.................................................................................................................shttlppNlpthppts...ts............ss.lhA..VsK.s.......hsts.h...h.p.hs...h.....................t......t..u.....h.....p.....................t.h..u.....s.p..l.p..Euh........................................................................pLp..psh.................lh....h....h.....................pp....l...........h.hp..........t...sh...h.....h....s...l.s...s.h.chh...p..tlpptt................................t.ps.lp..l..hl..p.....l.....s............s...uhp.................RhG..................lp...s......cch................phhp.......plpp..................h..ss......lp.l.t.Gl..hohhuts........................................-c.p...............htp....p...h....pp.h......................pphh.ptl..............pt..t......................hlS.h.u.sS..ushhht..................p...hhsh...VRhGhslaG.t..............................................................................................	0	960	1857	2470
+31	PF01315	Ald_Xan_dh_C		Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.35	0.72	-3.99	30	5239	2009-09-12 04:57:33	2003-04-07 12:59:11	17	77	1902	114	1766	4735	2068	108.20	30	12.95	CHANGED	TGcAhYsDDlshssst.ahshltSshAHA+IhuIDsspAhshPGVlullTucDlsstspshh....s.hsp.......lhAc-cVphhGpslAhVlAcspttAccAAcLVpl-YEcLs	............................................oGcupYs...-D...h...s....h....s....s....h....h...a..sth.l.pSs.h.A.H.A+......I..t...........u.lDs.st.A..t.......s.hPGVl..s..llT..tp..D...lss...h........t....hssh...........h..tsp........................hh..s.......s...s.......c..V.c....ahGpslA.hVlAcotttAccAsphl..c...l-Y-.L............................................	0	567	1035	1411
+32	PF02738	Ald_Xan_dh_C2		Molybdopterin-binding domain of aldehyde dehydrogenase	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	19.60	19.60	19.70	19.60	19.10	19.50	hmmbuild  -o /dev/null HMM SEED	547	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.43	0.70	-6.19	30	9467	2009-01-15 18:05:59	2003-04-07 12:59:11	13	89	2059	116	3266	9151	5213	368.20	19	64.65	CHANGED	Alc......ppshhsph............hphhppGD...sspuFspADt.......................llcuphphupQpahahETpuulAl.c.p-sclplasSTQsPphspphlApsLGlPtp+lclhspclGGGFG.pcscshshsshsALAAh+htRPV+hhhsRpEchhho.utRHshhhph+lGhsp-G+ltAlchchhssuGshsshu.slh.puhhts....ssYchsslchsuhsstTNhssss.AaR.GaGssQuhauhEshlcclAppLGl-s.ElRchNhh...cts.tsha.spphsshshhp...th-cshppspappRp.......ttlcp.....hshsp.pahc+Gluhsssphshshsss...tusutlplhsDGo...lhlphGus-hGQGhpTphtQlsAcsL.........ulshccIplppss.TspsPpusuTuuSpuoshsGtAltpAscplpc+Lp.htsphht.........shsacch........sssuhsssls.sApuhatss...........s.shphtt...s..spsh.hasaGssssEVElDshTGcscll+s.hlhDsGpslNPtlshGQIcGuhsQGhGhhhhEElhas.ssG.lhspuhhsYcIPshs-lP	......................................................................................................thh.........................................................................................hp.........h................hEs....hs...............t...............t......t..........t.....h.......hh...s.Q.........................t.....h.s...h.....h.....t.....h..................t..................t....l.....h............hG.GuFG.....t..........................................................s...h.....h.....h......s..h...h.....h.........t.....t.......s.....lp.................h...sR..p.h..t....t....................p.h..p......h...u......h..p.......t.......p.......G............l.............u....ht.....h......t........................h.....................t......................h....................................t.......................................................................................................Y......h......t..h...h..t...................h...s............................s..h.....h.R.....u.....u.s.....s.hh.h.E.hhp.h.A..tht......h..ssht.hR.hph......................................................................................................................................................................................................................................................................................................................................................................................................................t.........s.....l..........h...........s..Gp......h..l...sh..p..GpG.h...Thh.t...h..hup.h................................th.s....p..t..l.......h...................s......t..............t...................h.................s............................s.....h........u......S.t.............h.s...h...................s....s........h..t........h..h....h....t.........................................................h........................................................h.......................................................................................................................s.......s.....s......h..s.....l...t.l..s....................s..h...........p..l.p..h.................h.s.h..G.......lNs.h..tQ..............h.Guh.h...u.h.u..h.tt..........h.................................................t..........h.....................................................................................................................................	0	967	1893	2579
+33	PF00248	Aldo_ket_red	aldo_ket_red; 	Aldo/keto reductase family	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.57	0.70	-5.58	61	28932	2009-09-12 09:01:48	2003-04-07 12:59:11	16	110	4596	377	9885	23584	7566	269.00	25	87.49	CHANGED	pluhGshthst.............thspppshph...lctAl.ctGhs.....hlDTAph.........Y...........utuEph.lGc...hLpp.........+cplhlsoKs..................................ht.shstp.....plppslcpSLccLph.-hlD.lhhlHtsssths..........................hp-sh......ptlcchhp....pGpl+tlGlS...shs.hpplpph........tpttht.....hsssQspashh...........tthppplhp..hspp..p.slsll.uauslut...............GhLptt..........................................................................thhphlpplucp.hsh.ohsplulpaslp..............s.....................tsssslsGs..sshpclcpslpsh...ph.pLsppphstlcplht	.........................................................................................................luhGsh.th.........................ths.t.p.p.s.h.ph.......lctAl....-t...G.hp...........................hhD.T.A.ph.........................................Y...........................p.sE...p......h....lGc.....ulpp.................................h.R-c....l....h......l......sTKh..........................................................................................................h.....t..s....h..s.hc...................plh.p.u.l-.p.S.L...c.........+...L..........t.........h....D..........Y.....l..............D....L...a....h....l.H...h.....s..s...s..t..ss...............................................................................hp-..sh...................pAh.p.c.l...hc........................pG...+..l.+.t.........l.....G.....lS.....................Nas...sp.p...lpph.....................................t.ps.tht..................hs.s..s..Q.s.c.hshh................................h..p..p..p...l..ls.............hspp.......p..sl.s...hh..ua.....o......P.Lu.p..........................................................G...hl.t...t....................................................................................................................................................................h...pt.l.p..p.....l..A.....p.....c...h.....s......t...o...s...u........Q........l.....s.....L...t.Wh..l....................................t......................................................................................................t.s.s.ssIs.uu........sp.p..p..l...p..p....N.h.tsh........sh...pLotc-httlpth..t.................................................................................................................................................................................................	0	3142	5960	8241
+34	PF01263	Aldose_epim		Aldose 1-epimerase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.10	21.10	21.20	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-12.04	0.70	-5.31	66	8201	2012-10-02 23:57:29	2003-04-07 12:59:11	15	27	3660	74	1995	6054	1148	286.20	18	90.64	CHANGED	phlslpss.pthpsplhphGAplhShpsss.t...t-llhshsp.....ta.tt........ushlsthAsRl.ttGta.hpGtshplshNs................stpshHGtsps...phWpltphp.........stsphphh..sssc.ps...aPtplpsplsapLsspst...Lplphcupsst....cshshshs.HsYFNls.........hptpplplpu..pphhphss...hs....hshptssh.sh...ppsphlspch............thDpsahhss..........hphshhhhptspshtlchpsspsshhlassshht.................hhhpttuhshpsphhssssspsphs....hhLpsGEpaptphthp	..........................................................................................................t..hplpss...thps..p.l.h.s.h.GAplhu.hphss.....................pcll..h..s..hss..........t..h.tt......................hu..s.h.l.s.hus..Rl..tt........u...t.h...........h............t...G....p....sh.p.l...shsp......................ssp.s.h.HGh..scs........................p.Wp.lhpps............................ptlphs.h.p..................ssp..ts..................a...P...t......sh............plplpap.....L............ss.......s......s................lp.....lp.h..psp...s......s.............psh......shsh..s.Hs......Y.Fs.ls.....................hp.p.pp....lp....l...su.....t.thh..........h...sp...............h....s............t...........h...t.h.t...s....s.....s....h....-h........ppst...l.s.tp.............................................th..Dcs.ahh.t..............................................phthh.h.h..p...........p...p..t....h..t.l..p..h....t....s...s...t.......s..l.......l..a....ss...s.ht.....................................................................hhth..s...h.s.h..ts.p..h..h..s.s.p..s..t.......p.....s.....ths........hhLtss.p..hp.................................................................................................................................................	0	599	1167	1644
+35	PF03155	Alg6_Alg8		ALG6, ALG8 glycosyltransferase family	Mifsud W	anon	Pfam-B_3941 (release 6.5)	Family	N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid  (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one [1]. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147 [2].	25.00	25.00	26.20	26.00	22.80	23.30	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.88	0.70	-5.65	9	764	2012-10-03 03:08:05	2003-04-07 12:59:11	10	16	267	0	527	725	13	353.20	28	86.10	CHANGED	hsslhl+hh..LhPh.tp......sDFEspRpWhtIThsLPlupWYhpuosp....WsLDYPPhhAYapalLuhlupa.h.sschls.hpshGaES.sp..hlF.RhoVIhs-lLhhls.lhhaspsh...th.+..spppphhsuhhlLhpPGLllIDHhHFQYNulhhGlhlhuIsslhpcp.alhuAhhFslulsFKphhLYhAPsaFsaLLtp.Clp.sp....ht...........taspllpLussVlusFslhahPahhh....ppl.QVLpRLFPFsRGLhcshhA.NFWshaNsh.Kltphlsh.................................................plt..lohhhTllu.LPuhlhLahcPp....+hFhhuLshCuhu.FLFuapVHEKuILLslLPhslLhsttst..h.hhhhhsssuhaSLaPLLh+sshhh.phlhhhsa.hh.....hs........................p...thhh..hphlphhalluhhslhhh.phlp.hl...s.spKaP.LhllLsushuslshhhha...lah.h	.....................................................h....hh+hh..l..s...t............sDaEspRpWhtlT.pLPlppW....Y..h.t..........WsLD.YPPhhA............aapahhu...huth....h...ssthht..................p..s.....h.shts..th...hhF.RhoVlhs-hlhhhs......lh.......h.h......h......................................t....................................t........h...............h.h.....llh.suhlllDahHFQ............YNs.h..hGhhlhul..hh...t.............tp..................h....h.....uu.hhFshhlshKph.LYhu.sh.hha.LLtt....sh.............t...........................................................hhphh.tluhhshhshhh.h.hPa.h............................tth.QlhpRlFPh.tRGLhc...shhA.NhWshhsh..h......+hh..hh.....................................................h...hshh..hT.....h.h...h....................shh.....l....h.h......p..........sp...........................th.h.hslh.su...hu....FhFuapVHEKulLls......hlPh...sll..h...t.................................................hh...hhh..huhh...ohhP..LLhps..t.h..h.hhhhhha.hhh......................................................................................................t.....h.h........h..h..h..h......h..h...h......th...h.....hh...............p...h..l..hh.s.hs..th...h........h...............................................................................	0	184	291	438
+36	PF00245	Alk_phosphatase	alk_phosphatase; 	Alkaline phosphatase	Finn RD	anon	Prosite	Domain	\N	19.80	19.80	19.80	19.90	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.42	0.70	-5.79	10	3561	2012-10-03 20:55:17	2003-04-07 12:59:11	15	33	1898	200	1070	2985	602	329.70	28	81.45	CHANGED	AKNVIlhlGDGMGVuolTAARhLKsptcsphs.-h.LuhDchPhsGhu+TYssDpp......VsDSAAoATAahCGVKTspssIGVo............spGs-V..hSVLEtAKcAGKusGlVTTTclsHATPAuhhAHsssRshhussss.....ssthhptG.....ptDIucQLlssh...cIDVlLGGGR+aFh.pspss.......tttGhRhDGRNLlcEa......K+pGapYVhsRp...pLlpspssp.sp.LLGLFtsuchta-l.....................pccsspsPSLtEMT-sAl+lLo.+Np......+GFFLhVEGuRID+ucH-scshtALsEsltFDpAlctAh-hs..p-c-TLllVTADHoHs......aohGuYs.+sspshGLusupsssDttshpll.asp...GsGtslcs.........................tt+.slst.scthts.apppuslshsocsHoGEDVsVaAhGPpAc.......hl+GlpEQTplu+sMstAhsL	.....................................................................................KNlIhhlGD.G.Mu.s...hsssR...h......t..t.....t.................t......s................................................................................ht...........h.......-t...........h....h.u...........psas.st.........................................lsDSAssuTAh.sGhK..o....ss..sl..u.ls...................................pt...p...h........olh..c..h.A.c..t..t..G.h.ss.GhVsT.scl...pcATPAuh.hAHsspRp..s..s...............................................................p.hhpt.......................h-..V.hhGG..G..t..p...a................................................................t.hp.s.t.s.L..h.pth.............p..t....t....u.....h....p....h.s......s.t.t...........th......t.............p.....t..s.....p....................l.l...G....L.....F......s....s...s.p........h.......ht...h................................................................................p..t....t.....t.....t.....P.........o..L...tpMsptA..l..p..h..L.....p.....p..st....................pG.FFLh....VE....G...upIDhttHsss......h..t...........ht-hhth-pAlphA....hp......h.s.........p...p.......t......p....TL.llsTADHsps.......................s.t...............................t.......................................s.........h.........t............t.................................t.....................................p...........h..h..................h.........................s....................................................................................................................................................................................................t...s...tt...Hsutp..l...lh.......A..h.G..s.t..t.t........................h...G.h-ps.h.hh.hh.h......................................................................................................	0	299	560	845
+37	PF02806	Alpha-amylase_C	alpha-amylase_C; 	Alpha amylase, C-terminal all-beta domain	Sonnhammer ELL, Griffiths-Jones SR	anon	ref [2]	Domain	Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the  active site, interrupted by a ~70 a.a. calcium-binding domain  protruding between beta strand 3 and alpha helix 3, and a  carboxyl-terminal Greek key beta-barrel domain.	21.20	17.00	21.20	17.10	21.10	16.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.74	0.72	-3.85	246	4792	2012-10-02 20:10:03	2003-04-07 12:59:11	13	63	3353	197	1256	4323	339	94.60	25	14.30	CHANGED	W....ssssslluFtR.............stt....hlllhN...hss..hppsh.psulP..sG....p........Yp-ll....susttph....us.......s......t.......h..............h...pGp........h..plpl....Pshusls.ht.h..p	.........................Wl.hpcsspslluFhRt.......................spt.t...llslhN...Fs.s.s.....s.p.p...sY..pl.GlP...sG..........p........Yp.-ll................NoDs.tpa....uGs......sh..spttp................lpt...............................hs..cGp..............l.plsl....Psh...uslhht...tt.............................................................	0	397	756	1059
+38	PF05111	Amelin		Ameloblastin precursor (Amelin)	Moxon SJ	anon	Pfam-B_6419 (release 7.7)	Family	This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and  sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which  is though to have a role in determining the prismatic structure of growing enamel crystals [1].	25.00	25.00	30.00	29.90	16.90	16.90	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.48	0.70	-5.73	4	141	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	79	0	27	129	0	207.90	45	100.34	CHANGED	MSASKIPLFKMKDLILhLsLLKMShAVPAFPQQPGs.....PGMASLSLETMRQLGSLQGLNsLSQYSRaGFGKShNSLWhpGLLPPHSSFPWhRPREHETQ...............QPSLQPpQPGhKPFLQPTAsTuhQsTsQKsuPQPPhH.GpLPLQ-uELPhscp.QVAPSEpPPsPELPshDFADPQhPo..........................lFQIARhISRGPMPQNKsS.LYPGMhYhoYGANQL...............GGRssPhAYGulFPGFGGhR.slcthPpNPsMGGDFTLEFDSPVAATKGPEKGEGGAQGSPl.EApssc.ENPALLSplAPGAHsGLLAhPpDsIPuhARGPuG+.pthL.uVTPAAADPLhTPELAEVYETYGADhTTsLG.ptEATMDoTMoPDT.QT.MPGNKspQPQhhH-AWHFQEP	.....................................................................................................................................................................................................................................................................................................................................................shtuhP.NPshGGDFTLEaDSPsAuTKGPEpt....EGGspssPh.-spsss.EsPAhLsEht..PsshuG.LLA.PpsslPsLsRuPuGp.+t...tVTPAsADPLhTPtLA-sYcTYsuD.TTsls.pcEs..Th..DsThsPso.po..hPtN+sppPphhpcs....................	0	2	2	6
+39	PF01510	Amidase_2		N-acetylmuramoyl-L-alanine amidase	Bateman A	anon	Pfam-B_735 (release 4.0)	Domain	This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala).  The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	21.10	21.10	21.10	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.26	0.71	-4.10	117	7328	2009-01-15 18:05:59	2003-04-07 12:59:11	20	149	3627	173	1411	5665	2129	140.50	22	44.18	CHANGED	ttsttth..psphlllHpTssss..sts.t..............hhphps..............pssuhH...ahlst......cGp.....l..h.ph...hshs..........thuhH.su............................................h........Nst....s..lGl.phht.u....................................................sssQh.ps...ht..pL..hthl.........ppa.....s.ls.p........................plh..uH.......pcls...................sPush	...................................................tt.........phphlllHpTu.s.ss..spstt.h....................h...ts...............................pplusHal.lsp...................cG..p............l...h..ph...........lshs......................phuWH.AGs...........................................................................................h.Nsp.........S....IGI.Eltsst.........................................................................ttsh.ss.sph..ps.........ht....pL....sttl.............hppa...s..ls.p.............................plh.uHp-luspp...............sPu..h.....................................................	0	418	807	1119
+40	PF01520	Amidase_3		N-acetylmuramoyl-L-alanine amidase	Bateman A	anon	Pfam-B_888 (release 4.0)	Family	This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.22	0.71	-4.49	103	7380	2012-10-02 19:46:12	2003-04-07 12:59:11	13	197	3575	11	1463	5592	1358	194.90	29	50.10	CHANGED	lslDsGH.....G....Gp.Ds.....................G.....Ahu....ss....hh.EcslsLpl.upplt.ph.LpppG....hpVhhTRss.D.....t.h................sLppRsph..........A.....sp...hpuDlalSlHtN.uh............ssss......pGsplah...................................................ptptspupplApt...ltpp.ltpththt.......scG.......l+tss....................hhll..cp..sph.....PulLlEhGFloN.p-tphlpssphppp.lApuIspults	...............................................................................lhlDsGH.....G......Gp...Ds.................................G........AlG..................su......hp..EKclsL.p.l.Ap.clp...ph.Lpp.pG.......hclh.h.T.Rss..D..............hhl....................................................sL..p.p.Rs.ph...............A.........pp..........ppAD...lFlSIH.ss..uh...............................................ss..ss..s........pGsplah................................................................................................................................t.tph..ppuhplA....pt....lhp...p...lt..p..h.s.t.hp...................s+s.......................scp.us............................................hhVL....+p.....ssh............P.ul.LlEh..GFloN..sp.-..p.p.h.L.ts.sp.ap..pp.lApuIhpGlh.p.......................................................................................................................	0	519	1014	1265
+41	PF01593	Amino_oxidase		Flavin containing amine oxidoreductase	Bashton M, Bateman A	anon	Pfam-B_606 (release 4.1)b	Domain	This family consists of various amine oxidases, including maze polyamine oxidase (PAO) [1] and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines [2]. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium [3]. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines [1].  Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.44	0.70	-5.42	84	8963	2012-10-10 17:06:42	2003-04-07 12:59:11	19	111	2576	276	3844	15154	7049	357.50	13	77.77	CHANGED	luGLsAAppLtpt....Gh..............pVhllEAp-RlGGRlt..ohptt.....shhh-hGsphhh.s.ss.hhphhtphshp.phthh.tstthhhthphttt.hhthssth.........................................t.hhshtphhphttthtsthhthtpthhphtttsh...tphhhppshtphhht.....................................................................................................htshhhsthth..hthttust.hthhthth.shpptthhhshtt....hshhsthhsthts..ts...plphsppVpplphps.............ttststttsu..........thpsDt.Vlsssshsshp..............thhPthst.t.phh.pththssss.plhlphppthh.pt...................th.shhhsss...............ththhhhshphsss.....ttsshhshlhssts.....thhtshsccphhptlhpplpphhs.....th.ssh...............t..hppWtpsthstusashhsstss.....hhsthtssh.....................slahAGstsstth..sslpGAlpSGhpsAppll	..........................................................................................................................................................................................................................................................uGLssA...h.....L.....t.p.t...........uh................................plhl.hE......t......p....s........p.h.G.G.+....h.............s..h.....t..t...................sh..h....h..-.h....G...s...t.....h....h................................h.........t...h.....h.....t...............t.......h....h......................t................h.............................................................................................................................................................................................................................................................................................................................................................................................t.................................................t....h.............................................................................................................................................................................................................h...........h...h...............................t.................h............................h......................................................................................................h..................t........................................t..h........t.......h.......t...h...h...h...t........t..............plp..h..s...p.........V...pp.lp.h..ps......................................tt.h..t..l..h..h..t..sst..................................................hp.s-h..l......lh.s.s.s.h.t..hht........................................h...s.......h.s..t.................t....h........h...t........t.....h................h.....t...s.........s....hh..h....h..........h....t..t.......h.h..............................................................................th.hh.t......................................h......hh......t..................................h..h.....h......h..h...h..t........................................h..t...h....s.............p.....t.....h....h....t.........h.h.....t......l.t.p....h..hs.................t.................................................................t.h..........................h...........h..............h...t................t....................h..............h..t...............................................................................tlh.hsGt....h..t...........................h.h..ssh.su...s......................................................................................................................................................................................................................................................................................................................................................................................................................	0	1229	2344	3195
+42	PF00501	AMP-binding		AMP-binding enzyme	Finn RD, Eberhardt R	anon	Prosite	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.67	0.70	-6.09	354	67453	2012-10-02 15:58:18	2003-04-07 12:59:11	23	2256	6205	141	23415	62718	26362	376.00	19	52.12	CHANGED	hppps...pptP.cps.....Al....h..............tspplTYp-LppcusplAphL..t.p..h.Gl.p..tsc.h..Vulhh.pss-hlluhlAlh+sGushlPl..ss......shss.....cclthhlpcu.......psphll...s.............................................t.......hhhhp.......t....tt...................................................t.....sch...Ahll..Y..TSGoT....GpPKGVhloH.psl....hsh.hs.............ht.......tt........hh.hth.ss.......hsashu...h.htlhssLhtGu............................slllhpt..t.hs....thh...hp....hlp.c......hplT...hhhssPshhp.hl.......hp.t...t........................................ths...................s.L......+h..................................................l..h.......s..uGpslssphht.hpphhtt........lhss.YG.TEssshs.....................hhh...................ttt...hs.l.G...pP..l.....s.ssphtll..Dtt.tp.l...s.....sG.s...GE...lh.lp....Gs....s..lhcGYh........s.c...P.ch.....Tscp.ah......t...........................tt.ha+TGDlup.h.p.....D.G....h.lthlGRhc.c.lKlp	.......................................................................................................................................................................................h..........s...pt..Al...h..............................tttpho....a...t..p.....l....t....p..........p....s....p..p.h....A....t....h....L...........h.....t.................h.....G......l....t..............................s.......sh....................V.u...l.h...h...........p..s......................p..............h....h...........h......s.....h..h..u.h...........h.........p....h...............G....s......s....h.........s....s.....l.......s...s.....................................t.h..s..........................p...p...l.....t.....h.....h..l.p...p..s........................t..s.p....hll.................................................................................................................................................................................h.....h.....h.........h....p.............................t....................................................................................................................................................................................................................................ts......pch.....s...h....l..h......a........T........S.....G..o.....T..................G......p....P..........K............G..........V...h.....h.....s.....+.....tsl....................hs.t.h.h.t.h.........h.............t.......................................-....hh..hth...hs......................h.h..a..s....hu................h....h.t..hh..s..s.......l.....h....t.....G..u...........................................s.h...h.l.h.......s.......t.....h...............tth..................hp...............................hlp....p........................h.....p..s..o............h.h.h.s..s...P.s..hhp..hl.............................hp..t....................................................................................................................................shs...............s...l...+.h.................................................................................................................................................................................h...h.......................s.......uG..p....s...l..s...s......p......h..h......p......t......h..t..p.hhs.....................................l.h..p.s...Y.....G.................T.Essshs...............................sh.................................................tt....p.h.s.s...h..G.................ts.......h........................s...s...h......p...h...t......ll................D.t...p................h..p..h...........s..................................ut..............GE................l..h....l.p...............Gs.............s......l.h..p.........G......Y...h...........................p...p.........s...ph.....................o..t..pt...hh...s...........................................................................tt..h.a..c...T...G..D..luh..h..p..............t.........c..G..........................h...l....h....h..h.G.Rh..c..c...lhh.t................................................................................................................................................................................................................	0	6394	13492	19232
+43	PF05195	AMP_N		Aminopeptidase P, N-terminal domain	Finn RD	anon	Manual	Domain	This domain is structurally very similar [1] to the creatinase N-terminal domain (Pfam:PF01321). However, little or no sequence similarity exists between the two families.	20.40	20.40	21.80	20.90	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.84	0.71	-4.77	154	2593	2012-10-02 11:23:57	2003-04-07 12:59:11	11	16	2060	51	934	2167	1097	135.80	28	29.60	CHANGED	hstptatpRRpcLhppht................sulsllsuuspthRs.sDscYs.FRQ-Sp.........FaYL..................TG...asEP-ulhll.........ptp......t.lLFspt+-............ptElWsGhRhG.-sAhctausDpAasls-...lsphL.sphlpstp..t...laash..s.pssthc	...........................................tppatp.RR.ptLhp.pht......................suhsll.uus.ph...h..R....s..sD.s.c.Y.s.FRQ..sSs..............FaYl...................TG....h...s...E...P-.ulllL........................ststs......cslLFscs..+c.................ptElWh.Gt.Rh..u........-..t...A.pph.G.l..Dcsh..shs-.......ls..phL..phl..tths..h...lahs............t.........................................................................	0	292	563	795
+44	PF03098	An_peroxidase		Animal haem peroxidase	Bateman A	anon	Prosite	Family	\N	19.30	19.30	19.70	19.80	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	530	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.83	0.70	-6.13	123	2338	2009-01-15 18:05:59	2003-04-07 12:59:11	10	150	421	314	1401	2365	62	385.50	22	55.96	CHANGED	YRoh-GpsNNh..ppP.thG..ssss.asRh.lsstY..tcuhspsts............tth.LPs...........sRt.l..Spplh...tptp.......................hssssph....ohhhh.au.QalsHDhshssps.................C.t............t..shs....l.ls.sDshhs..........sh.hhRoh.s...ss.t.....................tpQ..............................lNphTualDuS.lYGsspptsppLRs...hpt.....GpL+...........ss.s...hhshs.........p.h..................hhhsG-tRssp.suLsshpslahREHNplAcpLpp.............h......................sPc..........................................................................................WsDEp..laQcARpllsA.........................h.Q+.................................IshpEalPtlL.Gp.p...shph.hh..............................................................hps..............Ys.slssslssEFtsuAaRahHohlssthhhhtpph................................tl....lpcthassp...hhpp.........................ls....hl.hGhhs.....................................psutphc...phhssplpppl..a...phstt........h.DLsulsIpRuR.D+GlssYNpaRchhs......Lpshpoac-ltt..........hssppl.............................hppLpplY...................................sss-slDlalGulsEp.h...Gu..............hhGsoh......ssllspQFp+h+pGDRFaa....E...ss..........................s.FTtpplpplp.....ps.oLscllscs.....h.th...tp..ht..ssF	..............................................................................................................................................t..h.R...h...s...................................................hP............st..l....hh.....................................................................................................................t......s.hh.......h.au...phh.a.ph..s.....................................................................................................................................................................................................hs..hothlDhu.lYGp.......s........t..t..tl.....R.......t..........G.hht............................................................................................................................h..h..u..p...h.h.....s......hl.....h.hthlahR.HN................h...lsp..L.tt......................................p..p......................................................................................................................................................h..ss-p.....l.....a....ppu.......Rhl.hh...u..........................h..p......................................l.sh.-al.hlh.s..........ht............................................................................................h.s................hp.....thsstl..s.F.shs.a+.a......Hshl.s.h.hhstph..........................................h........p.h..h....t..........h..h.t.......................................t...........hh...th.t............................................................................t.hst......t..ltp.h........h.........t......................cl..shsltcuR.c............h.....s.ls.shsphR.t...h.h.s....................................h......hp....s..ap-h..........................p.....t..h...............................................tthtthY...........................................................................tp..pt..l-la.GhhhEt...........st.................h.G.hh..............................phhh.ph.....t..............h.h...uD...+...hhh.t.....p...........................t.h.s...th..t.l.........p...sh.plhh.................................................................................................................................................................................................................................................................................	0	473	646	1103
+45	PF01821	ANATO		Anaphylotoxin-like domain	Bateman A, SMART	anon	Prosite	Domain	C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.	21.40	21.40	21.40	21.50	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.24	0.72	-3.82	65	552	2009-01-15 18:05:59	2003-04-07 12:59:11	13	71	77	20	202	520	0	35.50	37	3.14	CHANGED	CChDGhptss..hspoC-cRsthl.........tpsppChpsFhpCC	...CCt-Ghptts..hspoCcpRsthl............ps.tCtpsFhpCC.....	0	14	34	79
+46	PF01094	ANF_receptor		Receptor family ligand binding region	Bateman A, Finn RD	anon	Prosite	Family	This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.96	0.70	-5.66	119	7015	2012-10-02 13:57:41	2003-04-07 12:59:11	23	144	390	116	4127	13698	3388	312.90	15	40.55	CHANGED	thttAhphAlcclNpsss.hh...sshplshthtss.............................sstt.....ssshstphhtpptlhull..Gsssos.sstssuplssth..pl.Phloh.........................u.usssthss....tp..ashhhR..sssssptt.spuhscllpp..................asWppluhlhssssh...spth.......hpslppthpph.th.hhth.........tth.spspshp..shhptlpp.....pps+lllhtstssph......ptlhpps.......t.th..ttta.halhhshh.pt.....................................htstphtcshpuslshphhtstt.thpphhpphp...........................................................................ttt.shhshhhYDulhhhApAlpphhpppssthtst......................................................................s.tlh.phhps...........spa.......pGhsGplphsptssph.shthhhhphp	...........................................................................................................................h.huhpt.h.s...t...p.......h.................t....h..p..l..t....h.....h....p.......................................................................h............................................t.................h...h..u...lh.......G..s......s.st..................s..........................h......s....p..h...h.....t....h..h............pl....P................l.....o...h....................................................s...s....s...s.......h..ss...................t.p...as...........h.hp....hh.s..........s.....t...............t..............s....t....u......h...h....p....l.l.pt...................a.t..W.....p......h...l..s.h.l...h.....s...s.s..ph.........h..h.........................................hp.t.h.pp.....h...pp.....t........h.shth...............................h...t.....t..t...p.............p.......th.......p....l..p.p.......................t..............p.....sp...l.l..l..l..h...s..p..t.p.th.............................................ttlhpt.h....................th.......t....t....h....h..a....l.h..s.s....h.h....t...............................................................................................h.h.t............h..t....s.....h...h......s.....h.....t.......h..................p............p..................t...h.....p...p....a...h...t.p.h.p...............................................................................................................................................t..h......t.................s..h...h....a....s..AV.....h...s...h...A..h.....A.l..p.p.h...h...t...p..................................................................................................s.....p...l..h...p.hh..h.p.......................................h..p.h.................................................p.s....s.G..p.....h...p..ts...t..............h....................................................................................................................................................................................................................................................	0	856	1347	2917
+47	PF00023	Ank	ank; 	Ankyrin repeat	Bateman A, Sonnhammer ELL	anon	Swissprot_feature_table	Repeat	Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity [2][3].	20.60	14.70	20.60	14.70	20.50	14.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.19	0.73	-7.67	0.73	-3.89	1072	8812	2012-10-02 12:10:21	2003-04-07 12:59:11	25	2020	897	214	5230	139773	9187	32.40	29	5.11	CHANGED	pGpTsLHhAspps......................phpllchLlp....tuushshpsp	..............................................................................G.TsLH.h.A..stps............................................................................phcll.chLlp.........pGAshph.........................................................	1	2564	3256	4303
+48	PF00191	Annexin	annexin; 	Annexin	Finn RD	anon	Prosite	Family	This family of annexins also includes giardin that has been shown to function as an annexin [1].	20.90	20.90	20.90	20.90	20.20	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.96	0.72	-4.07	177	6936	2009-01-15 18:05:59	2003-04-07 12:59:11	15	27	307	347	3328	6752	29	64.80	29	64.50	CHANGED	hDAp.hLcpAhcshG...Tc-psllcIlsoRoptphppIpptYpptau.+sLpcslp.s-hSGcacchLlsL	.....................................-Ap..hLc.pu..h..+.G..h.G.............TD.E....ps...l...l....c..Il..s..s...R..o.p..t..p...l..p....p....Ip.p...tY.........p........p........h..a..s.....+......s..L.tc.....slc...s.......-..h....S.G.ca.cchllsl.....................	1	791	1389	2220
+49	PF03861	ANTAR		ANTAR domain	Yeats C	anon	[1]	Domain	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the  domain consists of a coiled-coil. 	20.10	20.10	20.10	20.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.33	0.72	-4.39	179	2458	2009-09-15 11:05:26	2003-04-07 12:59:11	9	45	1401	6	888	2155	145	56.00	30	24.33	CHANGED	phpplcptLpsRc........hI-pAKGlLMpp.ps..ls.EpcAachLRctuhppshpltclAcpll	.................................htplpptLpsR+.............ll-pAKGlLMpp.ps..lo.EpcAachLpctuMcpphplt-lAptll................	1	317	595	768
+50	PF04729	ASF1_hist_chap	Anti-silence; 	ASF1 like histone chaperone	Mifsud W	anon	Pfam-B_3167 (release 7.5)	Family	This family includes the yeast and human ASF1 protein.  These proteins have histone chaperone activity [1].  ASF1 participates in both the replication-dependent and replication-independent pathways.  The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers [2].	20.70	20.70	22.80	23.80	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.76	0.71	-4.58	24	449	2011-09-19 02:26:53	2003-04-07 12:59:11	8	4	313	29	308	425	2	145.60	53	66.27	CHANGED	M.S...hVslpslplh.sNPusFpsPapFcIoFEslpsLp-D.....LEWKllYVGS...............................Apspca...............................................DQhLDslhVGPlst.GhppFsFcussPshppIP....p-llGVTllLlossY+spEFlRVGYYVNNpYp-pELcENPPs.....ps.l-+lpRpIlsscPRVTRFsIsW-	................................MuhVplhsVtVL.sNPu.FhsPapFE.IoFEClE.sLpcD...............LEW...KllYVGS...............................................AcSc...ca..................................................DQ.LDSlLVGPl.Ps.Gh........ppF.lFpA..............Ds.Psssh.IP...psDhlGVTVlL.lT.C.oYcGpEFlRVGYYVNNE.Y.s..s..t..EL......+.....E.s......PP.s..............KP....h.-+lpRNIL.AppPRVTRFtIsW-...........................	0	115	168	246
+52	PF02822	Antistasin		Antistasin family	Bateman A	anon	PDB	Family	Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.	21.20	21.20	21.40	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.67	0.72	-3.63	60	460	2009-09-11 13:25:17	2003-04-07 12:59:11	9	70	93	8	298	535	14	27.10	43	9.73	CHANGED	Csthp..C...phtCshGappD.p.sG.Cp...h.CpC	..................Cstlt....C..........phtC.s.aGFppD.p.pGCp...h..CcC	0	107	126	218
+53	PF00847	AP2	AP2-domain; 	AP2 domain	Bateman A	anon	Pfam-B_409 (release 3.0)	Domain	This 60 amino acid residue domain can bind to DNA [2] and is found in transcription factor proteins.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.71	0.72	-3.81	206	5868	2012-10-03 08:51:45	2003-04-07 12:59:11	15	52	728	5	2816	5799	189	52.10	39	17.05	CHANGED	sth+GV..phcp.hs+...Ws..Aplh................t...pphhlGpass..-..cAtpshptsthphpst	.....................tYRGV....Rp+t....hG+...........Ws..AEI+c..s.........................p....pRlWLGT...FsT..sE....cAA+AYDtAAhph+G.......................	0	596	1740	2384
+54	PF02424	ApbE		ApbE family	Bateman A	anon	Pfam-B_1963 (release 5.4)	Family	This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis [1]. More specifically is may be involved in the conversion of aminoimidazole ribotide (AIR) to 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP).	20.00	20.00	20.20	20.10	19.00	19.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.54	0.70	-5.10	245	4122	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	2989	11	985	3311	1196	240.90	28	74.58	CHANGED	lpclsp.hSs..a..c..ss...S-lsclNpsss.hp..h..tlss-hhp..llppuhclsphosG...sFDsTl.GPLh.sLW.......uFssp............thPs...tppls................pthth..sshpp.hh............ttphhhppsshtlDLuuIAKGausDplsph.L..ppt..........Glp.shlVphG.G-ltsh..Gpp....pup.........s.......Wplul..p..s..P..............................ppt..........phht..hl.....plps.t...uluTS..G.sYcpaa.....s..Gp+apHllDP...pTGhPhp...pphsSVTVl..usss....ht.....ADuhuTulh..lh.G.....cp.uhphscp....ps.........ls.s......hhl	..............................................................................tthcphhSsa.p.....ts.....Spl...clNp.....ts......u....h......p.....sh........tl.s.t.phhp.llp.huhchuttosG....thDlol.GPLl.phW.........thG.pt................sphPs.......tp.pl..p............................................thh....t..h.....s.s.hpplhh.....................tppp..l.hhpp....ss.htlDLuulAKGYusDplsp.....h.....L..cpp.......................................Glp...shllsl.G.....G.s.lhsh......Gtp........sp.sp.........................s...............WpluI...p..c...P..p............................................tps.shhs.....hl....plss...t................ulsTS...G.sYc.pah..p....hs...............Gpc..apHllDP..........pTGh.....Plp...pp.....lsS.V.T.Vl.....u.s..s.u.............h.p............A.DuhuTulh.....sh..G.........pp....uhphhpp......ts....lt.shhl...............................................	2	336	675	848
+55	PF04049	APC8		Anaphase promoting complex subunit 8 / Cdc23 	Wood V, Finn RD	anon	Pfam-B_13808 (release 7.3);	Family	The anaphase-promoting complex is composed of eight protein  subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6),  and CDC23 (APC8).	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.99	0.71	-4.46	26	298	2009-09-11 06:08:17	2003-04-07 12:59:11	8	107	258	0	221	308	6	146.10	29	24.42	CHANGED	Mssp.......slpcl+ppLhtushpho-+sLhQSAKWu........AEhL.uLs.........................................ps.hsspsstpsttp...........spEh.-tYLLAKSYFDs+EYDRsAahLcssp...............................................SpcuhFLtLYupYluGEK+cpE-sptslssts.........sstNcchs	................................................h...........htpl+hpLhtuhhphscRsLhpuuKWu.....................AEh.L.uLs..................................................................................s....h.ts.ss.ptt.t...............................p-h.stYh..LAKoYFDs+EYDRsAahlps..sp....................................................op+uh..F.LthYupYLuGEK+..+p-.-p.t.hss.p.................................................................................................................	0	76	124	184
+56	PF04106	APG5		Autophagy protein Apg5 	Wood V, Finn RD	anon	Pfam-B_12134 (release 7.3);	Family	Apg5 is directly required for the import of  aminopeptidase I via the cytoplasm-to-vacuole targeting  pathway [1].	20.30	20.30	21.40	21.20	20.20	19.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.15	0.71	-4.83	34	341	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	279	5	222	339	2	200.20	30	65.17	CHANGED	WahPlGlLaDLhsssssh........................................................PWplplHass....aPsptLl.hssc..........cslcstahsslKEAsal+sGs.......scsIhshscpDpppLWpulhs..cshcpFhpIspKLh............................s.psth+pIPlRlYlsss..................hthlQphlpsh.................tpsp.h.TLt-hLpphLPshh.................................................stp..........ptphspsllpGIclsh..csPlp.lscphsasDsFL....aIslhhh	........................................WahPlGlLaDlhs.sss.h..................................................................................................................................................................................................................PWplsl.Haps....aPpp.Ll..hssp.......................cslcstFhsslKE.......ADhl+pts........psl.s.hp+cDp.ppLWtul.s..c........cac.pFh..tlsp+Lh.....................................................................................s.ttssh+pI.....PlRlYhsss..................................................................h.hlQphh..t..sh...........................................tpsp.p.TLschLpplh.Pshh...............................................................................................................................tp..................t.thspshlpG..l.pssh....csPlt.lscphu.asDsFLalslh.............................................	1	76	119	183
+57	PF04602	Arabinose_trans	arab_transf; 	Mycobacterial cell wall arabinan synthesis protein	Waterfield DI, Finn RD	anon	Pfam-B_4670 (release 7.5)	Family	Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the   macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1].	25.00	25.00	28.00	27.90	17.90	22.20	hmmbuild  -o /dev/null HMM SEED	657	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.09	0.70	-6.34	7	497	2012-10-03 03:08:05	2003-04-07 12:59:11	7	7	176	8	90	457	0	565.40	47	61.09	CHANGED	cussps.RIARhVAslAGlhGhlLslssPLLPVpQTTATlpWPQ....sGplsplTAPLluhsPpsLslTlPCpAsAsLPsss....GlVlSTsPttGh-AscsGLhlcsspssVsVshRssVsssAPRstVsu....ssCphlchhAsssussA-FVGlst.....suGp.......ss-hRPQlsGVFTDLpsPAssGLuhpssIDTRF.TuPTsLKhhAMlLGlssslhAllALthLDphsttth+h...hlPhtW.................hssthsDssVlusLllWHllGAsoSDDGY.LThARVup+AGYhANYYRaFGosEuPFsWYaslLAhhApVSTAulWMRLPshlsuluCWLlISRpVLPRLGsu...lsssRsAhaTAGuhFLAAWLPFNNGLRPEPlIALGlLlTWsLVERAluhpRLhPsAlAhllAhhTlsluPpGLIAlAALLsGuRsltplltRR+ptsGhhs.lAPLhAAsoVlhhllF+-QTlATVlEus+lKhsVGPolsWapEaLRYYaLhlto.sDGSluRRFAVLshlLCLFsslhhhLRRu+lPGsApGPsWRLIGhThhohLhLhFTPTKWshpFGsFAGLuGulGALsAhAsophuL+oRRNhslalsAlLFVLAhuhAulNGWaYVSNaGVPW.st.PhlstaslTohFLsLollsuLlAuWhHFph	.............................t.........h..+hhAhluG...llGh..lLslhsPlLPVpQssAplsWPQ...............sG...p.h.s.....sls..APLluhsPhshsholPC.ssht.....s...Lss..st................slllu.ThP.tt..u...c.A...st...p...uLhlps........s........t......s......t......lsls.Rssslh.s.sshppl...u....ssC.ptlpltustst....stA......phsGl.t.............sGs.....................................s........shRPQlsGlFTDL.......p.......s.....s.......A......s....s.....G..........L...shpsslDoRasooPTsLKhhshll.ulhh..slsuLlALhhLDp.h.-Gt..pth.c..................hhP.spW...........................................................hp....phhDssVlusLlhWHhlGANoSDDGYlLsMARVupcAGYhuNYaRWFGsPEuPF.GW.YYslLAhhspVSs.Aol.W.MRLPsLhsulssWhllSRcVlPRLG.u....ltss+..sAh..WsAAhVFLuhWlPaNNGLRPEPlIALGsLl.TWs.lERulutp.RLhP.uAlAslhAuhTLssuPoGLhAlusLls.uhpslh.pllh.+.............R.............p..................t......h.........................G.............h.h....s....h...lA......PhhAAuollhhslFtDQTLuslhEus.+l+ttlGP...ohsWapEhlRY.hLh.h.o.sDGSluRRFulLhhhlsL.hssl......hhhLR......+..t.RlP..GsAtGPs.hRl....lGhh....hhohhhhhFTPTKWsHHFGlaAGluuul..uAls.slshuth.sh+.sp...RNRshah..u.u..l......l.F.l..hAhuhuuhNGWWYVusaGVPW.st.Ptltuhsh...oohhL...s....Ls.llshhhAsW.Hhh..........................................	0	15	61	81
+58	PF03079	ARD		ARD/ARD' family	Mifsud W	anon	Pfam-B_2276 (release 6.4)	Family	The two acireductone dioxygenase enzymes (ARD and ARD', previously known as E-2 and E-2') from Klebsiella pneumoniae share the same amino acid sequence  Swiss:Q9ZFE7, but bind different metal ions: ARD binds Ni2+, ARD' binds Fe2+. ARD and ARD' can be experimentally interconverted by removal of the bound metal ion and reconstitution with the appropriate metal ion.  The two enzymes share the same substrate, 1,2-dihydroxy-3-keto-5-(methylthio)pentene, but yield different products. ARD' yields the alpha-keto precursor of methionine (and formate), thus forming part of the ubiquitous methionine salvage  pathway that converts 5'-methylthioadenosine (MTA) to methionine. This pathway is responsible for the tight control of the concentration of MTA, which is a powerful inhibitor of polyamine biosynthesis and transmethylation reactions [1,2]. ARD yields methylthiopropanoate, carbon monoxide and formate, and thus prevents the conversion of MTA to methionine. The role of the ARD catalysed reaction is unclear: methylthiopropanoate is cytotoxic, and carbon monoxide can activate guanylyl cyclase, leading to increased intracellular cGMP levels [1,2]. This family also contains other members, whose functions are not well characterised.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.82	0.71	-4.28	11	964	2012-10-10 13:59:34	2003-04-07 12:59:11	9	12	776	3	436	1144	153	149.50	30	82.56	CHANGED	phahh--psp.Dp+lPccpsPtchhphpcLsclu.hhha+lsscsppsscchpplhch+shshhsh..........spssscphPpa--KlcpFaEEHlHsD-ElRahlcGsGYFDV+..sps-sWIRlhlcpGDLIllPsGIhHRFTsssssalKAhRLFsssstWss	.................................................................................................................p.t.t...p.hs..t......t...........tlt..h..h......ch.s..t.s..................s.s.p.p..h..t.hltthp.sh..t.h..................l.hshps.s..t..P.s....h....-....p.h....lppF.hpE....H.hH.s.D.-.E.lR.ahl.sGpG..h..F.s.l+.....sp.s.....ct....ahclhscp.GDLIslPAGhhHh.F..s.h.s.s........s.s.h..lp.A............lRlFssp.sWss..............................	0	130	246	354
+59	PF01412	ArfGap		Putative GTPase activating protein for Arf	Ponting CP, Schultz J, Bork P	anon	SMART	Domain	Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.	27.50	27.50	27.50	27.90	27.00	26.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.97	0.71	-4.31	141	3394	2009-01-15 18:05:59	2003-04-07 12:59:11	13	165	341	30	2020	3186	33	114.20	32	18.59	CHANGED	pphlppltp...h.ssN.phCsDC...s..stsP.pWsSls.hG.....lalClcCSGl...HRs.LG..s.......HlS+V+SlsLD..p..Wsscplphhpth.GNp.pssphacsp.....................sst..........ssppphcpaI.ppKYtp+t.as..pst	.....................................p..hhpplhp..h.ssN...phCsDC....s............u.s....P...pWASls.hG............lhlClcCS..Gl.H.R..s.LG.s.............................H...lS.+V.......+....S..ls.LD........s.....W.ss.p.......p..l......p......h..........h.pph...GN.s.t.ss.p..haEsp................................t...s.ss.......................ssppphcp.aIpsKYpp+tah..t....................................................................................	0	652	1022	1510
+60	PF01388	ARID		ARID/BRIGHT DNA binding domain	Bateman A	anon	[2]	Domain	This domain is know as ARID for AT-Rich Interaction Domain [1], and also known as the BRIGHT domain [3].	21.00	21.00	21.00	21.30	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.86	0.72	-4.13	53	1730	2009-01-15 18:05:59	2003-04-07 12:59:11	16	96	289	17	1077	1669	7	89.90	29	8.00	CHANGED	pspspppppFlcplhpFhcppGss..........h.tchPt................lst+.lDLapLaphVpchGGhc......pVscp+p........WsclupcL..shss.....ttssu...........ppL+stYt+hLhsYE	..................................................t.....tctpFlppLhpFhc.p.p...G...s.s................................h..p+.h.Ph....................................l..s.t+.LDLapLaphV.p.ch.G.G.hp....................p.V.sp..p.+t.............................W.p.clsppL..sh..s.s........s.pssu...................s.sL+ptYp+h.L.hsaE........................	1	277	474	782
+61	PF04683	Proteasom_Rpn13	ARM_1; 	Proteasome complex subunit Rpn13 ubiquitin receptor	Waterfield DI, Finn RD, Coggill P, Wood V	anon	Pfam-B_4497 (release 7.5)	Family	This family was thought originally to be involved in cell-adhesion [1,2], but the members are now known to be proteasome subunit Rpn13, a novel ubiquitin receptor. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain [4]. The domain forms two contiguous anti-parallel beta-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold [5]. Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37 [5].	25.00	25.00	25.70	25.50	22.50	24.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.14	0.72	-3.90	78	393	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	279	4	246	369	1	86.10	40	26.93	CHANGED	G+hphc....s......phVpPcscKG.hlhlhpsc.-....sl............h+FpWpsRss.......spsEp.......-lll..hPs-spFpclsps............psGRVasL.+Fpsusp+.hFFWhQ-t	..............G+hplc....s......phVpP-t+KG.hlaltp......s-.D.......sL.................lHFsW+sRss.........spsEc................DLIl..hPsDspFp+V..sps............soGRValL.KF.pu.....uspR...hFFWhQ-...................	0	78	132	204
+62	PF00514	Arm	Armadillo_seg; 	Armadillo/beta-catenin-like repeat	Bateman A, Ponting C, Schultz J, Bork P	anon	SMART	Repeat	Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.	20.60	20.30	20.60	20.30	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.45	0.73	-7.89	0.73	-3.96	242	12724	2012-10-11 20:00:57	2003-04-07 12:59:11	18	321	451	497	7518	13312	326	40.80	24	18.23	CHANGED	ssp.ptphll..psGslshLlpLLp......sps.plpppAshuLsNlss	..................tptphll..psGs.lshLlpLLp...............sss.pl.pp.p.AshALsNls.......................	0	2088	3612	5404
+63	PF00339	Arrestin_N	arrestin; 	Arrestin (or S-antigen), N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Ig-like beta-sandwich fold.  Scop reports duplication with C-terminal domain.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.74	0.71	-4.39	42	2044	2012-10-02 22:29:00	2003-04-07 12:59:11	24	33	301	26	1377	2143	4	138.80	19	29.63	CHANGED	hslhls....p.chlaasG..-sl......sGpVll.sspp.hcs.RtlhlplpGts+sshpc.cshshphpc.............t...p....shhchpphLhpp..............h.hGsasaPFpaplP...ss.PsShpuphG........tlcYpl+shl....-ts.hchspp...pppshhVlphlshs	..........................................................................................................................h.ht....p..t......h..ss.......p.l............sGhlh..l....p......t.....h......ph...p..t.............l.hlphput..hcht....h...p...p.....ps..h...s..p...tt.......................................................................p.t....th.h.p.hp.t.t....l.h.tp..........................................h.........G..p.a..p.....a.P.F.ph.p......l.....P.......t.s..h....P.....s..S..h..p....h.p....G......................................tl.pYp.l.cuhl...............cps.....t..h...p......hpp.hhllp.h...........................................................................	0	452	648	1092
+64	PF02752	Arrestin_C	arrestin_C; 	Arrestin (or S-antigen), C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Ig-like beta-sandwich fold.  Scop reports duplication with N-terminal domain.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.69	0.71	-4.06	173	1981	2012-10-02 22:29:00	2003-04-07 12:59:11	17	29	291	26	1311	1936	0	151.20	19	30.82	CHANGED	tsstlphplslsppuas.Gpslslplpls.......N.pos.hs.........lpplphpLhpphpahspt.......................................................................ppp.ptpphlsp..pttssl....................................tstppsphp..hpl...........plP...........................................................slss...os.........................................................psphIplpYplclplphs........................t..plphplPlhl..hps...sh	..............................................................................................................................................t.ps.lplphsls+..ps.as.....G.-s...lsl.p.h.pls.......N.po..s.hs.....................lp...plcsp...lh.pph...shhsp...............................................................................................................................................................................................ppp.phpphlsp..tpstsh............................................................ssss..shp.......hpl......lP..........................................................................................................................slss.......ohh.........................................................psphIpl.pYp.lc....lplpls.........................................t...httcltl..clPlhlhp......................................................................................................	0	417	606	1041
+65	PF04959	ARS2		Arsenite-resistance protein 2	Moxon SJ	anon	Pfam-B_5269 (release 7.6)	Family	Arsenite is a carcinogenic compound which can act as a co-mutagen by  inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance [1].	21.10	21.10	21.20	21.70	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.52	0.70	-4.15	8	282	2009-09-11 08:45:49	2003-04-07 12:59:11	8	12	212	1	189	287	1	200.40	25	26.08	CHANGED	MPNRCGlIHVRGPhPsN.RITpsE..............................VsEapKoaEEKLuPLLuh+-sLSE-EApKMG+KDPEpEVEKFVoANTQELuKDKWLCPLSGKKFKGPEFVRKHIhNKHu-KlEEV+KEV-FFNNYLtDAKRPuLPE.KPh.sPGsst..ssshuP.uhs.YsPQ..sPQuhhPaGtP...RPPhhGa........s....GGPsFPPs.aG.......................uGRGNYDsFRGQssthuhP+s.R.hcGs	.........................................................................................................................................................................h......p..a...+s..h-pKl..h.Lp....p...p.................-....h..pK..hGt.K...s.....s...-....p....tl.Echlp...t.s..pc..scs..K.....ahC..Ph..s.......u..KhFK..us-Fl+KHlhpKHs....Ehl....c....c..l...+...p....E...l...t...aaNN...Yl.....h...D...Pp+..P.s.h...sc.........t...t.....s....s.s..............................t.s......s.......a....t.....................h..................................................................................................................................................................................................................................................................	0	65	107	155
+66	PF01037	AsnC_trans_reg	ASNC_trans_reg; 	AsnC family	Finn RD, Bateman A	anon	Pfam-B_773 (release 3.0)	Family	The AsnC family is a family of similar bacterial transcription regulatory  proteins.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.17	0.72	-4.27	263	13775	2012-10-02 00:20:33	2003-04-07 12:59:11	16	36	2996	126	3987	9832	2190	73.20	21	46.93	CHANGED	ltlplp.pp.........hcphtctltp......hPEVhpsatloG.shDall+lhs.pshpshpphltp...ltplssltps.poplllpp	.......................................................lplp.pp.........hpphtptlpp...........hs....E..V..h.psahl.oG..chDall+lhs.p......sh.pphp..chltch....l...t.p...lsu...l.pps.pohllhp............................	1	944	2215	3156
+67	PF05118	Asp_Arg_Hydrox		Aspartyl/Asparaginyl beta-hydroxylase	Finn RD	anon	Pfam-B_2775 (release 7.7)	Family	Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes.  Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure of proline 3-hydroxylase contains the conserved motifs present in other 2-OG oxygenases including a jelly roll strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within the extended family.  This family represent the arginine, asparagine and proline hydroxylases. The aspartyl/asparaginyl beta-hydroxylase (EC:1.14.11.16) specifically hydroxylates one aspartic or asparagine residue in certain epidermal growth factor-like domains of a number of proteins [1].	20.10	20.10	20.10	20.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.92	0.71	-4.41	11	1101	2012-10-10 13:59:34	2003-04-07 12:59:11	10	40	713	5	388	906	1501	146.90	31	44.69	CHANGED	pLppNWptIR-EuLtLts...httuttas-tuasshhKssWcpahLhhhsstpssAtphs.PpTssLLcplPpspu.................shFupL.PGuclhPHpDPasus.....lRhHLGLsTP.s-tChIcV-spcpsW+-GEsllFD-oa.H.utNpo-psRllLhhDl.+P.	............................................................................h..ptpW..IRpEh..tl................t.........t...........s.........s..........s........h......ct...sWcp..F..hL..h........hh...s.t............t.h....ss.....s.t.............p..hC....P.....pTs.pl..l.p..p..l.Pshpu............................AhFuhL..sPGscls.Hc..s...P....hsup.........lRhH.L..GL.h.......sP.....p.............s......t............C....hl.....p..V.....s...s.....p.....p.....h....s....W.c.....-.....Gcs.llFD.-o.a.H.shN..c.....s...s.....p......s...RllLh.sDl.+P...............	0	129	195	286
+68	PF01177	Asp_Glu_race		Asp/Glu/Hydantoin racemase	Finn RD, Bateman A	anon	Prosite	Family	This family contains aspartate racemase, maleate isomerases EC:5.2.1.1 [1], glutamate racemase, hydantoin racemase and arylmalonate decarboxylase EC:4.1.1.76 [2].	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.87	0.70	-4.43	177	8372	2012-10-03 04:39:14	2003-04-07 12:59:11	17	13	4320	108	2004	6434	2979	210.50	21	83.24	CHANGED	lGhl..sstushshh...ppl.........tphhsst.......................hlhhtssp.............hhptt.............................h..hhh..............pssptl.t.......tssc................................sllluCsos.shhtshp.....tt....thP...l.ls.hscss............ht........th.t......thp+...lullus..hsshtsthhpphlpp..G.....l........p..t.......th........shhp...hup.hsst...htthhpthp............ppss....-sllLu.CTphshh.phhpth..t..........h.......llDsspshsp....ts..h	...................................................................lGhh..Sshuslohh....cpl....................hc.hlsppp...................hl.hhtsss...........thP..........ppstpp......................................lhph.hh....................p.h.sp.tL.p........tssc.............................................hlllAC..N..Tu..p..s......s.s.h.thh........................pp.h..slP...............l..lu..lhpsu............................hc..................shtp......stsp+..........lull...uT......psTh...p.s..s...h...a...p...pt..lpph..s......l........................p..t..................th..hh............pls-.........tup..hpsp........shphltphlp................h.........ppss.............-sllLG.CT.chsll.hs....l..pphh.t............l.......llDostthsct..h.....................................................................	0	548	1190	1650
+69	PF01400	Astacin		Astacin (Peptidase family M12A)	Bateman A	anon	Swissprot	Domain	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3.  Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain.  All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin Swiss:P07584, a digestive enzyme from Crayfish. Meprin, Swiss:Q16819, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila Swiss:P25723.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.34	0.71	-4.91	26	2029	2012-10-03 04:41:15	2003-04-07 12:59:11	19	142	328	13	1290	1935	24	172.70	33	37.99	CHANGED	ppWsps......IPYhlssshsspp+shlppAhpcacppTCl+Fh.ps.......scsshlhhhpssGCh.ShVG+p..sGt.QslSlG.pGC..phGllsHElhHAlGFaHEpoRsDRDcalsI.apNI.sut.tsFpKhs.spssshGhsYDYsSlMHYsstuFSpss.hsTlhs+sst...hpssIGQRhphShhDlpplNphYpCss	.................................................................................................h..W.........lPYh.l....s.....s..p..........h........s..t...t...........p..p......t......h.l..hpAhppa...p.p......p......T......C.lc..Fh.ps.........................pppt....h..l.........h......h..............p......s.......s....G...C..h....S...h.l....G..............+............p.......s...........G............t........Q...t..l.....S......l............s.......t............s........C.................p........h.......G.............h.l....hHEl...hHulGFaHEpoR......s.......D......R......D.........p...a....Vp.I.......h...p........N...I.....................s.......s..h........p.......h................N...............F.......t.....c.......h..............p.....t....p.s........s...............s................h.........s.h.........s..........YD..asSl.....MH..Yu.t......h........s.............F.....o.......t.....s.......s.........................s........T.......Ihsh.s...........................ts.l.G...Q..R.....t.hSt..hDlh.......pls..thY.pC..t...................................................................................	0	532	658	1119
+70	PF02178	AT_hook		AT hook motif	SMART	anon	Alignment kindly provided by SMART	Motif	At hooks are DNA binding motifs with a preference for A/T rich regions.	14.50	0.10	14.50	4.00	14.40	-999999.99	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.40	0.75	-6.23	0.75	-3.59	40	2152	2009-11-26 15:21:48	2003-04-07 12:59:11	14	167	542	4	1233	2051	224	12.60	52	7.35	CHANGED	p+tRGRPpKstsp	...tRtRGRP+Kst..t....	6	380	638	979
+71	PF03029	ATP_bind_1	ATP-bind; 	Conserved hypothetical ATP binding protein	Griffiths-Jones SR	anon	Pfam-B_1301 (release 6.4) & Pfam-B_2154 (Release 8.0)	Family	Members of this family are found in a range of archaea and eukaryotes and have hypothesised ATP binding activity.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.56	0.70	-4.83	30	1967	2012-10-05 12:31:07	2003-04-07 12:59:11	12	16	660	9	1105	2459	404	206.90	26	79.02	CHANGED	VsGssGuGKTTassulschh.hpth...hlNLDPus..h.a.s.hslc-hlohsclhp-..hslGPNGulhhuh-...........................ahphsl...h...tccl...........................tt..s...hhLFDTPGQlEhathhsshs.hhp.h....phshssVhLlDopphsc...sssahushh.s..hhh.hplPalsslsKhDlhs.........h.hh.t........................hppLspslsphl-phshs.phhssuspsppuhpsLlshl-pthpt	............................................................lhGshGsG..........K..........TTas......t.slpp.hh..................h....p.......................................................................................................................................................................h....c..-......h.ls.h.t.slhp-..................hslu.s.p..u...u.h.h...hu.....h.-......................................................ahph...sl................pppl.....................................................................hh..LFss.....P...G...Q..h..............c......hah.h.h.s..s..hs..............................phsl.s..slh.L....l...D.o....p..p.h.s.s.........ss.cahss..h...............h...h..............hc.l.P.al.ss.lsKh...Dhhp...........................................................................................................................pthspsltthlp.h.....s..s.....hhs..s...t...p.p.t.pu.hptlhthlcps...h......................................................................................	0	386	688	948
+72	PF00306	ATP-synt_ab_C		ATP synthase alpha/beta chain, C terminal domain	Finn RD, Griffiths-Jones SR	anon	Pfam-B_15 (release 1.0)	Domain	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.85	0.71	-3.60	150	20853	2009-09-12 08:32:44	2003-04-07 12:59:11	22	34	11148	406	3509	16060	5135	103.40	33	21.66	CHANGED	tplusplpth....LtpacELpshsp....h..hG.-tL.u-pD.+h...h...Lp..+.uc+lcc.hLpQ....stassh...........s.................................lpc...plphh.....h.tllph..hpphs.pth.ttl........t............hpphcphtp	......................................csAppl+psLppY+ELp-lls........l..lGh......D-Lo-pD.+hp...lsRA++lpc.aLpQ...shassp.....s..t.phhs........................................................................lt-...slpsh.....h.tlhp..G...hD..pl....P.ppth..hhh.t..sh..s.......................tt.........................................................................................................	0	1226	2225	2960
+73	PF02874	ATP-synt_ab_N		ATP synthase alpha/beta family, beta-barrel domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	20.90	19.00	20.90	19.00	20.80	18.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.90	0.72	-3.76	196	22044	2012-10-02 13:55:04	2003-04-07 12:59:11	18	33	11118	393	3707	16715	4934	65.20	30	14.01	CHANGED	lsplhGsVlslthst.s.hsslhsslplp..c...........tp.hh.h.uhshpLtsspVtslshssTsGlpc.GspVhsTG	..................................................p.hGsVlsV.......t.......s...........s......p.....h......sl..s..shtschhc.................................s..ss.h.tlt.pLtssp..Vtslshu.s..o..........cGlpc.G.pVhcTG..................	0	1311	2362	3125
+74	PF04718	ATP-synt_G	ATPsynth_g; 	Mitochondrial ATP synthase g subunit	Waterfield DI, Finn RD	anon	Pfam-B_5977 (release 7.5)	Family	The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport.  It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L). The function of subunit g is currently unknown.  The conserved region covers all but the very N-terminus of the member sequences. No prokaryotic members have been identified thus far [1].	25.00	25.00	26.40	26.20	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.28	0.72	-3.37	37	369	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	264	0	237	356	3	99.30	30	72.48	CHANGED	sscssphsst.slhau+stlphh+phh+sE.LsPP.s.uchpphhpshhphhp............hpsss......hh..hp..pls..hc-ushsulhusEllsaFhlGElIGR.RpllGYps	.................................................................h.thssthsst.slhau+...stlp.hhhhhh+sE..lsPP.osuch...phhpslhphhp.................hpsss............h+...pls.............sc-shhsul..husEllsWFhlGElIGR.tpllGYp...................	0	67	119	188
+75	PF03768	Attacin_N		Attacin, N-terminal region	Finn RD	anon	Pfam-B_2791 (release 7.0)	Family	This family includes attacin and sarcotoxin, but not  diptericin (which share similarity to the C-terminal region of attacin).  All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically  to kill the invading microorganism [1].	23.90	23.90	25.30	35.40	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.85	0.72	-4.10	17	105	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	32	0	30	120	0	66.10	44	30.45	CHANGED	htGolTsNscGuussss+lshs.sscshhsAlGuV.hsssp+....hussTtGlshs.NssGHGhSLo+o+	.......huGSlouNPsGGusAplclshs.lGssptsslGpVFAuuNop......uGPVTsGssluhNssGHGhSLT+TH..	0	7	9	20
+76	PF03797	Autotransporter		Autotransporter beta-domain	Bateman A	anon	[1]	Domain	Secretion of protein products occurs by a number of different pathways in bacteria.  One of these pathways known as the type V pathway was first described for the IgA1 protease [2]. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in.  The N terminus contains the variable passenger domain that is translocated across the membrane.  Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs [1].	22.00	20.80	22.00	20.80	21.90	20.70	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.69	0.70	-5.04	212	8209	2012-10-03 17:14:36	2003-04-07 12:59:11	14	136	1526	14	904	6497	851	238.90	16	26.88	CHANGED	sstpsshWspshushtp....pspsstsuhp......tphsGhtlGs-tth.......s.sshhlGhshuhspuphp....................s.stsupspspshtsuhYsph............................psshhlsuths..auhhcp.......thts..............tptpupapspshssplpsuaphth..........pshtlpPhsplpahtsptss..apEps.....t.hshpht.pshpslpsplGlchphpht..............................thpsh.hphshtap.hsstppsstss.....t......hsht..hscsshthpsGsphpls.pphsl.hhshs.....tptspss	..............................................................................................s...t.shWhphhusp.p........ts......s..s........thp...................tphtshpl..GhDhhh.................s.sph..hh..Gh.h.huhspsphp..............................ssttup.s.ps...pu...ht..huhYush...............................tsshalcsh..hp..hshh.pt..........t.ts...........................t.psph.p.u.pshsss..lcs..G.h.p.ath..............pshhlpP....s.p.l.pa....t..hpt.ss..ap-ss.......................s..hp.h.p..s.pshpshts....plG...hch.shp.hpht......................phpsh..hphshhpp...hssstp...ht...hss..............................shttt.hst.s..th..phthGh.ph..p.hs....pphsh..hhshs........h......ttt.................................................................................................	0	205	439	657
+77	PF03547	Mem_trans	Auxin_eff; 	Membrane transport protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs & Pfam-B_5261 (Release 7.5)	Family	This family includes auxin efflux carrier proteins and other transporter proteins from all domains of life.	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-11.80	0.70	-6.17	25	9093	2012-10-02 17:06:44	2003-04-07 12:59:11	13	27	3153	0	2760	7555	2542	180.00	10	85.92	CHANGED	sshpsll.lhllhllG.Yhus+h.plhss-pspslNchVhhhulPsLhFpplupssshphhhphhhhslhhhlhshlshhlsall.....s+.hh+hshchptslhshushsNssslGlPlLtulaGs...................tuhuhhlhhsslsslhhaolhh..................hlhp.putph.h.tt.s........................................................................................................................................................................................................................................................................................................................................................hhh.h..hhhh+hlhsPsshusllullhuhl.sahhsh.h..................phltpolslLusuulPhshhsLGlhLuhp.hhhshssthsth.........hhlRhllsPhlhlshshhhu..l.s..hhpshllp............sAhPsuhsshlhAppaslp.chsSsslhhuhllulhshslah	............................................................................................................................................................................................................................................................................................................................................................................h.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................................................................................................................................................	0	820	1729	2289
+78	PF02310	B12-binding		B12 binding domain	Bateman A, Mian N	anon	Pfam-B_359 (release 5.2)	Domain	This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2].	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.47	0.71	-4.24	133	8147	2009-01-15 18:05:59	2003-04-07 12:59:11	14	80	2972	71	3031	7333	2597	115.00	22	16.83	CHANGED	hpslhssstschaslGht.hlushlcp.t.Ga.........-Vh..hl.......shps...ps................................cpllp.tltph.ps-l..l.ul.....Ss..........hssshsth..tclhct......hcphtsplhlllGGshsshs.ph...t........hu.sshhhGpG.csshtslh	...................................................................................................s.phlhuphttDsHD.l.G....tp.ll....ush....l....ps....t...Ga............-.Vh......l.......s...h.hh.....ss.....................................................................................-cllc...tA.h.cp...ps-..l......l.Gl..........Sul.....................hss...s...h...s.t...h....hp.l.hct...............hcp..t....t....s....l.h..ll.lG.G.s.h..s...s....tsh.....t...................t.s...................h.......................................................	0	1180	2176	2679
+79	PF02607	B12-binding_2		B12 binding domain	Bateman A, Eberhardt R	anon	Bateman A	Domain	This B12 binding domain is found in methionine synthase EC:2.1.1.13 Swiss:Q99707, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of Pfam:PF02310. The structure of this domain is known [1], it is a  4 helix bundle. Many of the conserved residues in this domain are involved in B12 binding, such as those in the MXXVG motif.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.39	0.72	-3.95	255	3838	2009-01-15 18:05:59	2003-04-07 12:59:11	12	34	2594	16	1269	3424	1047	78.30	34	9.66	CHANGED	ttphhpplhpullph-ppthpphlpp...........sl.p..........hsshpllpchlhsshpclGchap.psphhlsp.hhuuphhcpslshlhs	...........................................ltc+LppullcG.pchlppssc-..........................Ah.pp.s.........................hpPlclIpssLhsGMsh.VG-LFs..pGchFLPp..VlpSAcs.MKpAVuhLpP.............................	0	482	904	1109
+80	PF02362	B3		B3 DNA binding domain	Bashton M, Bateman A	anon	Pfam-B_582 (release 5.2)	Family	This is a family of plant transcription factors with various roles in development, the aligned region corresponds the B3 DNA binding domain as described in [1] this domain is found in VP1/AB13 transcription factors [2].  Some proteins also have a second AP2 DNA binding domain Pfam:PF00847 such as RAV1 Swiss:Q9ZWM9 [1]. DNA binding activity was demonstrated by [3].	30.10	30.10	30.10	30.10	29.90	30.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.41	0.72	-4.37	114	2169	2012-10-02 12:51:43	2003-04-07 12:59:11	16	44	101	2	1310	2264	0	98.00	24	23.90	CHANGED	Fhphh.....h.ssshpp.....shl...slPppF..sppp.........th..........tt.plhlps..pG............ppWphph.........pppspt.....hhls.......pGWppFspspsLp.sGDhlsFp..h..tt.psh..hlplhpts	..............................................Khh.h.oss.spt......s.th......slPcpaucph..........................t................tt..plh.h.cD..hpG.............ppWph+a...h.....................pspspp.......hhLs.......sGW.pp.FVpsppLt.sGD..sllFh......h....ps...pph..hltlh...s.........................	0	219	746	1021
+81	PF01313	Bac_export_3		Bacterial export proteins, family 3	Finn RD, Bateman A	anon	Pfam-B_898 (release 3.0)	Family	This family includes the following members;     FliQ, MopD, HrcS, Hrp, YopS and SpaQ All of these members export proteins, that do not possess signal  peptides, through the membrane.  Although the proteins that these exporters move may be different, the exporters are thought to  function in similar ways [1].	25.00	25.00	25.00	25.30	23.60	24.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.49	0.72	-4.30	202	3289	2012-10-03 02:46:00	2003-04-07 12:59:11	14	2	2171	0	652	1501	334	75.20	37	85.64	CHANGED	p.l..l...slsppAlhlslhluuPhllsuLlVGLllulhQAsTQIpEQTLoFlPKllulhlslhlhusWhhspl.hsaspp	.......t..llthsppAhhlsLhluuPhlllAlllGLllulhQAsTQIpEpTLoFlPKlluV.hlslhlhusWhhshLhsasp.t...........	0	203	390	513
+82	PF02673	BacA		Bacitracin resistance protein BacA	Mian N, Bateman A	anon	COG1968	Family	Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol [1].	20.80	20.80	20.90	20.90	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.61	0.70	-5.19	287	4568	2012-10-03 02:02:08	2003-04-07 12:59:11	13	2	3924	0	995	3043	2915	255.80	36	94.07	CHANGED	pAllLGllpGlTEFLPlSSoGHL.llssplluhp................s.uhsFslllQlGollAVllhFhcclhplhtshhpt...................................tptst+hhhhllluslP.ssllG.ll.hcchIc.....shh.t..shh..........h...luhsLllhGlllhhu-phspp......................hcshcplshpsAlhlGlsQslA.L.l.PGsSRSGuTIsuuLhlGhs.RcsAAcFSFlLulPshhuA..uhhclh....................c.hhp...........hss..s.sh....h.lhlGhls...uFlsuhlslchhlcalp+p...shhsFuhYRlllG....lll	................................................................................AllLGlVEGlTEFLPlSSTGHl.Il.s.s.c.l.lshp...............................shspsFpllIQLGulLAVllhahc+lhtlht.thhtt.........................................tptshphhhpllluhlPusl..l.G....ll.......hc..D..h..Ic............shh........ssh..................s..VuhsLllsG.llhlhs-...phppp.........................................................................thpslccloappAhhIGhh.Q.sLA.l.l.PGhSRSGuTIsGGllhGh.s.Rp.sAu-FSFhLul...PshhGA.ss.lclh.........................K..hhph..............hss....s...sh...........shh.hlGhlsAFlluhluI+hhlpalp+t....satsFuhYRlllGhl...............................	0	336	666	853
+83	PF01011	PQQ	Bacterial_PQQ;	PQQ enzyme repeat	Bateman A	anon	Pfam-B_1319 (release 3.0)	Repeat	The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilise pyrrolo-quinoline quinone as a prosthetic group.	20.30	20.10	20.30	20.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.89	0.73	-8.05	0.73	-4.17	130	3998	2012-10-05 17:30:42	2003-04-07 12:59:11	16	133	1153	135	877	8732	2893	36.40	26	10.04	CHANGED	sthhhs..shsGtlhAlDspT.GchhWphpsssss.stshs	................h.hh...shsu.lhAlDhpT..GchhWphphssss..................	0	220	462	667
+84	PF03704	BTAD	BAD; 	Bacterial transcriptional activator domain	Yeats C	anon	Yeats C	Family	Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR (Swiss:P25941) along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.57	0.71	-3.89	64	2191	2012-10-11 20:00:58	2003-04-07 12:59:11	12	200	672	3	901	2383	154	140.00	25	19.33	CHANGED	lDlppFcch.sttGptshttG.c.tpAsptLppALuLW+GssLuslts......tshhpspst+LcEtRlpsh-tph-....scLpLG...Rtp..chlsELpsLlspaPh+EphatpLMhALaRsGRpu-ALpsYcclRptLs-ELGl.-PuspLppLpptlL	..................................................................hDh.tFtth...htt..u..thh..t.t....t....p............t.t.uh..th..h..pp..AL..s.........L.........a..+..G...s.s.Ls.s.hss....................h..h...p...s..t..t.t....p...L..c....c...h...pl..p....s..hc..p...hs..c.....ttl.thG..............ct.s......ps..ls.t..L.pp.lls........tcPh..c..EphhttLhtALh.psGR...p....uc...ALps.Ycch+phL...t.c.E.LGl.-.PusplptLhptlL....................................	0	399	719	858
+85	PF01426	BAH		BAH domain	Bateman A, Aravind L	anon	[2]	Domain	This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction [3].	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.87	0.71	-4.35	41	2185	2009-01-15 18:05:59	2003-04-07 12:59:11	13	109	308	34	1324	2175	2	128.50	19	14.46	CHANGED	tphplG-hVhlpsss....................................scs.....hhlsplhcl.......................................................................................................................................hpsssss.......thlc..spha..........hRPp-s....hhspthsp.......p..Elahosc...ptsh.hpslpu+CpVhhtsch.stp..h....................tsshF...aCchhYss.pptsFppls	...............................................................................................................h..hpl.G.DhVhl.psps.......................................................................sp.........h..lu..cIpcl.......................................................................................................................................hpsppsp................hh.hp...spWa...............................................h+Pc-s...............t.tcthtp..............................pElF.h...osp..........h-shs....h.s.s.l..h.GK..CpVhh.h..p..c.....h.pp.h...psht..................................................ppcsa...hhphhYs..pptth.....................................................................	0	367	643	1003
+86	PF01145	Band_7		SPFH domain / Band 7 family	Bateman A, Finn RD	anon	Bateman A	Family	This family has been called SPFH [1], Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.28	0.71	-4.37	120	13903	2012-10-01 22:02:33	2003-04-07 12:59:11	20	43	4514	5	4366	10740	5942	188.90	21	54.61	CHANGED	hhlss..................sphull...hp..hGchpp..............................shpsG....................hph.hhP....................hhpphh...hhshp.hpphphss................................................sshopDt...........hslsl...shsl.pa..+l..........................scshphhtph..............t.ps.......hpphlpshlpssl+shl....uphsh...p-lh.........ss.....................+.splspplppplp..........................................................pp.....................hpphG......................lp.lh..slp.lpclphsp...phtps...lppphtupppt......................ptphtpuctcs	..............................................................................................................hVtpsptull..........hp........hG+hpp..................................hh.psG....................................lph..hlP.................................hl..cplt......................hlshc...hpshchss..............................................................................................................................................psl.Tp...D.p................................ssl.p.l.......ss.s..l..ha....+l................................pcstph..hhsl.........................................................ps..............hc.p.t....lpp....h...spss...L....Rsll..............................Gph..sl.............-cll....................................................sp...........................................R.pp....ls.pp.l.pp.t..ls........................................................................................pp............................h..s..s...a..G.....................................lp..lh.....clp...l.p.......clp..sp..........plppu...............ht.pph.pAcppp......................pAthhpAcu..t.............................................................................................................................................................................................................................................................................	0	1454	2620	3579
+87	PF03594	BenE		Benzoate membrane transport protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.30	20.30	20.30	20.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.20	0.70	-5.91	9	1251	2012-10-03 01:44:59	2003-04-07 12:59:11	8	2	1036	0	255	994	220	346.90	45	93.78	CHANGED	sshs.SsllAG.hlAslluYuuslsIhapAA...psAtsossQhuSWlhululuhulsulhLShRa+sPlloAWSTPGsALLlouhsshslsEAlGAalVuuhLlhLsGlousFs+llppIPtulAuAMhAGILhtFulpshpAlsspPhLshsMlhsYLLsRpauPRYuVhhlLlsGlshuhhhGphphsslsh..clupPpalsPsFShtAhlsLALPLhLVuhsuQ.lPGhAlL+usGY.psPsuPllssTGLAShlsAPhGuholsLAAIoAAICpGP-AH.Dss+RYhAulhsGhFYllhGlFuuolluLFuuLPtsllshLAGLALLGulusuLttAhp--ppR-..........AAllTFllTASGhohlGlGuAFWGLlhGhlshhl	.......................................s.sslhAG.hlAlLlGYuS.ShsllaQAA...tsuG...AosuQluuWhhALuluMGloolh.Lo.l..hYRsPl.lsAWS.TP.....G...A...ALL...l.o..u..lt..G..h........o.....h.s....-AlGsF.l....lsssLlllsGloGhFsRLhp.h.IPtulA..uAMLAGI...LLp.............FGl..psFsu...lssp.s...L....shsMlhsaL.....l...s...+...th...s...P...R..Y..........A.....l.....lu.....s.h.....lh.....Gl...s.....l...s....h..h.....t....G...p.l..s..h...s.s......l.t.h.....ph.s...hP..sa..l...sPpFS.hushlul.A.l.............PLFlVTMASQNhPGlAsh+AsGY.....p..........sPsuPllshTGLhuLlhuPFGsaulslAAITAA.IC.tus-AH.D.scRahAuhssGlFYllsGlFGuslsulhsALPhshlthLAGLALLuoIuuuLhpAh.p..s..p.cpR-..........AAllsFLVTASGloLhGIGSAFWGLluGhlshh..................................................................................................	0	54	114	193
+88	PF02944	BESS		BESS motif	Bateman A	anon	Bateman A	Motif	The BESS motif is named after the proteins in which it is found (BEAF [2], Suvar(3)7 [3] and Stonewall [1]). The motif is 40 amino acid residues long and is composed of two predicted alpha helices. Based on the protein in which it is found and the presence of conserved positively charged residues it is predicted to be a DNA binding domain. This domain appears to be specific to drosophila.	20.80	20.80	20.80	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.34	0.72	-4.37	43	441	2009-01-15 18:05:59	2003-04-07 12:59:11	15	14	44	0	223	465	0	36.70	27	9.80	CHANGED	pDsDp.hFLhSlhPtl+pLsspp+hch+hclhpllhch	.....ssDp.hFLhSlhPhl+pLss.pp+hch+hclhpllh-......	0	53	68	167
+89	PF02369	Big_1		Bacterial Ig-like domain (group 1)	Bateman A	anon	Bateman A	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity. 	30.40	30.40	30.40	30.40	30.30	30.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.43	0.72	-4.10	20	5706	2012-10-03 16:25:20	2003-04-07 12:59:11	11	124	515	5	385	5116	64	96.30	26	34.44	CHANGED	hls..phpAsloplh.......Asss-ssTlTAoVpDtsGsPlssppVoF.....ssstssLsss.....shTcssGhAploLouo......psGstsVoAols.sssss.pspsV	.................................s.....tuph.s......h.h...t....hhA..s...sss.s.so.lpA..sVp.D...s...p.G...N.s.l..s..s..t.sVsF............ssssss...ls.s.s......................spTss.sGh.A.p..l.o..l....o.u.s.........p.s..G.s..hs.V.oAo.ls..ssssp.p..................................	0	82	201	296
+90	PF02785	Biotin_carb_C		Biotin carboxylase C-terminal domain	Griffiths-Jones SR	anon	ref [1]	Domain	Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step  in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are in  this C-terminal domain.	20.70	20.70	20.70	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.09	0.72	-4.06	109	10242	2009-01-15 18:05:59	2003-04-07 12:59:11	14	97	4650	113	3077	8078	3751	106.20	38	14.54	CHANGED	EsRlhAE..DPtps.....F.hPus.G.plsthp.h...............P............susulRlDou.ltp.....Gs.plssaYDsMlAKlIsa..ussRppAlp+hppAL.schp..ltG..lpTNlsaLppllppspFtsu.....phsTsal-	................................................EsRIsAE......DPtps.........F..hPus.G.......c.l.p..php..h...................................P.........................uG..GV...RlDou..l..h.s................Gh..slsPaYDSMluK.l...............Is..a......G.p..s.....Rpp.Alt+hppAL..p.E..h..h.............l..c.....G.......l......p......T.Nlsahh.p.llps..sF.tsG.........shsTpal-.......................	0	942	1879	2586
+91	PF02012	BNR		BNR/Asp-box repeat	Bateman A	anon	Bateman A	Repeat	Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in many glycosyl hydrolases as well as other extracellular proteins of unknown function.	23.00	12.80	23.00	12.80	22.90	12.70	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.75	0.76	-6.08	0.76	-3.20	188	830	2012-10-02 00:45:24	2003-04-07 12:59:11	15	46	547	34	224	1738	836	12.00	57	2.20	CHANGED	hhSpDsGpTWpt	...hSsDsG+TWp...	0	106	173	212
+92	PF00528	BPD_transp_1	BPD_transp; 	Binding-protein-dependent transport system inner membrane component	Bateman A	anon	LMB bacterial genome group and Prosite	Family	The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.97	0.71	-4.78	81	156339	2012-10-03 05:18:07	2003-04-07 12:59:11	17	117	4892	36	36523	106567	36248	195.90	15	65.39	CHANGED	ulhlGhhsu...hhhsphhcphlhshh.hhh.....slPshh.......lhhl......lh..............................................shht.tshhs.h..lhlhhhhhsshshhhptthlp.tlspshhcsucshGhsphphlhphhlPsuhsslhsshhhshsts.ltssshhphlhs.........lGhhhhpuhhshshs.h.................................hhhhhhslhhlllsllhshlhphls.+hpt	............................................................................................................................................................................................h.hGh.hhu.................h..ht..h....h....h....p..t....h...h...t...h...h...h........l...h.h.........s.l..P..sll............................h.hhh.................h.h.hh.....................................................................................................................................................................................................................h.t.h.ht....h.....s...h...h...s....s..........l..l...s....h....s....h....h...h......h.......s......h......h.......h...h......h....h..t....s....s....l.p....s....l...s..p...s....h.......h-..A............A.p.s.....h.G.s.............s.p....h.p.hh.h.clh..L.P...t..s...h....s...s...l.l....s...s.h...h...h.s.h...s......t...s....l...s......s......h....s...h...s...t......h......l........s......................................h.s.t...h...h....h....t.....s.......h.....h.....t....h....t...h.s.hh.......................................................h.hh.h.s..h.s..l.h...h...l...l...l..s.h.l..h...h.h....t.h.h......t............................................................................................................................................	0	10630	22134	29422
+93	PF02237	BPL_C		Biotin protein ligase C terminal domain	Bateman A	anon	Bateman A	Domain	The function of this structural domain is unknown.  It is found to the C terminus of the biotin protein ligase catalytic domain Pfam:PF01317. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.15	0.72	-4.27	50	3072	2012-10-01 19:11:18	2003-04-07 12:59:11	12	11	2996	75	760	2212	402	47.40	30	14.56	CHANGED	hlGcpVplpt..tstpl..pGhspuI.DcpGtLllctssu.............hctlhuG-l.ht	...................lG+tVplhh.....ssppl.....pGlupuI.DcpGtLllcpssG.......................hp.s.lhuG-lsl................	0	221	459	621
+94	PF03099	BPL_LplA_LipB	BPL_LipA_LipB; 	Biotin/lipoate A/B protein ligase family	Bateman A, Reche P	anon	Reche P	Domain	This family includes biotin protein ligase, lipoate-protein ligase A and B.  Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites.  Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organism probably has only one BPL.  Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine [2]. Lipoate-protein ligase A (LPLA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes [3]. The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor [5].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.78	0.71	-4.11	66	11826	2012-10-02 14:22:40	2003-04-07 12:59:11	14	48	4791	113	3031	8364	4175	120.70	19	40.71	CHANGED	huppt.sst............hthpthppsslhlsccpouGp.....tsacs.hu.slhaollht.t....p...h..h..shthshssh.csL.....................t..s..h......h.sDlhh............ss+Kl..uGlhhch......pt...ttthpthslslshs	................................................................................thh...p.p...s.....s...l......l.......s..c.p..p..o..G....Gp..............ts.a...p..s..............ts...s...lhhol.....l.....h......h......t.......p...t.......................................htth...........shhht.h.shl..csL.........................................................t..u.s.p.sp.......hp..h.N.D...l..hl.........................................ss.+.Kl......uGlhhch................pp......sst.hp....t..h.s.lslshs........................................................	0	1020	1916	2578
+95	PF02485	Branch		Core-2/I-Branching enzyme	Mian N, Bateman A	anon	Pfam-B_842 (release 5.4)	Family	This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme (eg Swiss:Q06430) and core-2 branching enzyme (eg Swiss:Q02742). I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development [1]. Core-2 branching enzyme forms crucial side-chain branches in  O-glycans [2].	23.40	23.40	24.30	23.50	23.10	22.30	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-5.22	47	1645	2009-01-15 18:05:59	2003-04-07 12:59:11	16	15	375	10	869	1568	50	236.40	20	55.03	CHANGED	lAFhals.+GsLPhh.lW-pFhp...sH.cs..haslYlHsp.ss.hpp.h.t........sshF.sR.Is.SptVsaGphohlsA-++LLAsALh.D..sNchFlLLSpSClPLhsFsplapalhps..spSFl-shspss.ttp.sRas.p......hhP..clphp...............caRKGSQWhtlsRphAhhl..l..tDshhashFppaC...................................ssChsDEHYhsTl.........lshh..hsstssNpol.......TalcWs........pttsHPtpat....hpslo.chlpplp	......................................................lAahhhs..p...s....h.hh....hhhphh.....h....t...............pshas.lalDtc....s..t.ht.p.th.t......................ps.h.....s.s..h.h..h...s.......p..........t..l..ha..ush.ohlpAphphh..........tsh..........L.....p......................s......h.....s......h....caal.L.SusD..hPlpo.p...p...........l.h...phl..........p.....t...........................t......p...p.................s.....h..h...p..p..h...p......t..s............s...h.h...........h.p....t+....hp.h.............hh......hthp.................................................................thphhtG....S.t............Wh..sLo.....Rpas....pal...l..........pD..ph...hhphh...phhp....................................psh.h..s...-Epa..atTl........................lp.....t........ht.....p.....s..h....h...s.ps.l.............................phh...pWs.............................tph.......t.hs.t.h....h....................................................................................................................	0	213	446	651
+96	PF00533	BRCT		BRCA1 C Terminus (BRCT) domain	Bateman A	anon	[3]	Family	The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage.  The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs [2]. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilised head-to-tail BRCT-BRCT oligomerisation mode [3]. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants [5].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.45	0.72	-3.83	114	8489	2012-10-02 11:51:29	2003-04-07 12:59:11	21	297	4740	142	3410	8863	1950	78.30	25	11.50	CHANGED	tttphhpshphhl.......tthpphp+ppl...pphlpphGupl.........................tsph.sppssall....ssps...................tt.tc.............httshphshtlls.pWlhcsl	.............................................................................................s.....htGhshll...........sush.p..p..h.s.R..s.ch..............cph.l.p.p.h.G.u.+l................................................................................ssol....o...c.c...T..s...a.ll..............sGcs................................................su..sK.......................................ht.cA..p........p....h....G......l...p....l..l.s-p.hhp.............................................................................................	0	1124	1906	2771
+97	PF04089	BRICHOS		BRICHOS domain	Sanchez-Pulido L	anon	Sanchez-Pulido L	Domain	The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialised intracellular protease processing system [1]. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, Pfam:PF08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region [2].	21.10	21.10	21.10	21.30	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.12	0.72	-4.12	40	591	2009-09-14 09:13:14	2003-04-07 12:59:11	9	13	95	6	287	508	1	93.50	25	36.19	CHANGED	huuucsushlaDappslsAh+shstppCYlhphspstlPshpsLtchhhph......ptpsth.ssphhcpphh.....sspplpDhshLG.tI.tpLCtshPhYhl	.....................ssucsushl.aDFp..ps..loAhhs.h.......shp.......pCalhthsps.hl.s.cslhchhhph...................pttshh.p..ohh..hpcphh.....sspplp-...h...s..L.G...hI.hpL..CpshshYhh.......................	0	42	57	123
+98	PF04427	Brix		Brix domain	Bateman A	anon	Dlakic M	Domain	\N	28.10	28.10	28.30	28.30	27.70	28.00	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.40	0.71	-4.64	149	1923	2010-01-08 13:34:18	2003-04-07 12:59:11	13	24	441	1	1305	1849	23	196.60	24	58.96	CHANGED	l..hsu................p...psspphpphhcDLpplh..Psup........phs+tp......h.php......chhchst.ps....ssslllh..pppct.psstlhls+h.....spGPoh....pFp............l......ps...hphhc-l..........t...............Phllhsshtsp....................hphlpphhpshFss........hs..t.......phc+llshp.t.....................p.........pch................................IhhRpa.h...............................p........................................................................................................hpLpElGPRh.slc...........lhcl	................................................hpup..pss.tphpphhp-lpt.....lh...Psup.....php+tp...................t..plp....................phl.phsp.ps....soslllh..............pp....p..cp.....p....s.......ss......L......hls+h........PpG.Poh........pFpl......pshphhc.-.lhtthptsh.....spp..................................................PhLlhsshtsp........................hphltp.hh.tp.lFss...........sh.............thc+Vlshs.t...................p...cch.................................................................I.hRpa.h.......hhp.............p..............p.................................................................................................................................................................hpLtElGPRhslplhc...........................................................................................................................	0	469	738	1083
+99	PF03097	BRO1		BRO1-like domain	Bateman A, Kim J, Mistry J	anon	Bateman A	Domain	This domain is found in a number proteins including Rhophilin Swiss:Q61085 and BRO1 Swiss:P48582.  It is known to have a role in endosomal targeting.  ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1 [2].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.12	0.70	-5.71	70	1087	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	297	31	739	1088	8	341.70	21	47.18	CHANGED	shlslshKcop..pl-..hspsLppaIpppY...spsssh...a.....pcclpplspLR....pshhs.........psstsulch........................LhcYaspLphLpt+h..P....sppht.l...........pFsW.aDuh...........................tpst......shspps..ltaE+uslLFNluAlaoplAspp..........sp...p.ss-GlKpAsshFQpAAGsF....palp-s...........hhpsPoh....D..lstpsLpsLtpLhL..........................AQAQEshhtKslt...s................shcsullAK.......LuspsuphYpps.........hpshppsshtt...............................................hp........tpWhshlphKtta......apAlApYatuhsh.....................................pppppaGct.......l...................................Ac...............................LptAhptlp-Ahphtth...................ttttlhpslpthpsplppcLpptp+D.........NDhIYhp.lPs.ssls...slt.shshs+sl.shsp.h............pt.p...ssclFppLlPhsltput......ohas-cpsphlppph	............................................................................................................................................+....s......hp..h.....h.thl.t.h...tp...................h............tpth.t.thtt.hR....................pthht............t...thhph...................................lh.pYhs..L.hl....t..+h.....s..............tpp.t...l.............................................Fp.W...hssh..............................................................ptt.................hs.ps.....ltaEhsslLaNluulhophus.pt................................sp.....s..sp.p...u.h....+.t.A...hphap....p......A.A..Gha........palpcp..............................................h..psss.......D.....hs.pslp....sL.plhL................................................................A.QAQE..shh.tKsht.......p...........................phpssl......lA.+.......lus...ps...sphYppu..........hpt.hp..p.....s..s..t..t..................................................................................................................h.........ppWhthl........phKtth......atAhAph..atuhth......................................ppppph...Gptl...........................................................up...............................L.ptA.phhp.puht.tt.............................................t...h.t.hpthh....ptlp...p.phpphp+-.........N-hlY.h.p.lPs......t.h...................ht...h.hst..sh......................................a..thhP.th....t.ht...........h........................................................................................................................................................................................	0	248	387	590
+100	PF00439	Bromodomain	bromodomain; 	Bromodomain	Finn RD	anon	Prosite	Domain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.74	0.72	-4.06	69	7921	2009-01-15 18:05:59	2003-04-07 12:59:11	20	370	355	282	4778	7646	90	84.20	26	10.39	CHANGED	hpplh........p...phhppt...st.F.t.......stpthssYhp.......hl...ppPhsLspIpp.......+l...csspYp...s...................................h..tpahpDhphlhpNuhpa........st.tss.hhp....tupp	................................................................h...........h.ppp........huh...s...FhpPV........................stp..p..h..P..-.Y.a.c.........................lI............+p.PM....DLs.Tl.c.c..................................+l...............cs..p....p....Y.p.......s............................................................................................................................h...pca.h..........p.....Dh.pL.......hhpNshtY.............Nt..sso.lhp.u..h.............................	0	1623	2367	3612
+101	PF03909	BSD		BSD domain  	Yeats C	anon	[1]	Domain	This domain contains a distinctive -FW- motif. It is found in a family  of eukaryotic transcription factors as well as a set of proteins of unknown function.	20.40	20.40	20.70	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.85	0.72	-4.23	81	1184	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	308	4	822	1161	12	60.20	21	16.77	CHANGED	hst.ppph.sh...t.p........tcphpplLppsss.LpphhpchV.......PptlscppFWppYFhththhptptspp	....................................s......ph.ph...p.p........hc.hppllppsPt...lpphatchV............Pptls.c....p.p....FWpp.aFhthhhht.ptt................	0	250	448	674
+102	PF03092	BT1		BT1 family	Mifsud W	anon	Pfam-B_1804 (release 6.4)	Family	Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants [1], thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member  of this family) was previously noted [2]. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted  prokaryotic proteins (from the cyanobacteria Synechocystis and  Synechococcus).	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	433	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.50	0.70	-5.77	12	726	2012-10-03 03:33:39	2003-04-07 12:59:11	11	11	173	0	486	924	508	341.70	21	71.34	CHANGED	pGlus.lhphss.hhhp-chGlssuthQtLsslushsWslKshhuhlsDs.ashhGYp+R.YhhlSslhG.h.uhhauLLsuh.sSsshAuhhlhLuohuhA.sDlls-uhhschhRppPps..usuh.ShhWhh.hlGullushhsGsLs-thtsphshhloAsl.hlshl..................suhhlhcp..........................................................................................Eshthscs...sphhs.....+cslsp.W+hhhh.............ssIhtssL..............hhshashslslspA...................hFYhsTspht.....FohpFhspVt.llGsluuLlGVslasthhpphsaRhhhhloslhpsluulhDlIlVc+hNhhlGIsDa.hallGDullhplshhltaMPhlVLhuRLCPpG.EuslaALlhuhhsLGpssSutLGulLhcahh...hTpss.....asNLshLlllsslss.LlslPLshLL.s.t...c.hDtsschspcts	........................................................................................................................................................................................................................................h..hsh..hhpp.hthp..ss..t.hth.....ht..shh.t.h.PWs.h.Ks...hhGh.loDs..h..s..l..h.G.a...+.....R+sY.h.h.l..u....t...hl...s.......h....h.........h..h............h.u..h..h...............s......t..............................................h.............................h......h......h..........h..h....h...h......s......h....s..hs..........h.....-.....l.h.-..uh...h..s.......p.......................t...............s..................................t............s............t............h.........................o...hh......h.h.........h...u.s..l.....h..........s............h.h.....s..........G........h.......h.......p.................h.......................p..................h.......h..h............hh...h.h...h............................................h...h........................................................................................................................................................................................................................................h.t...hthh.....................................................lh.shh........................................hh.h.h...h.........ts...........................................h..ah..t....h..............h.s...............hhs......hht..hhs.......thh.hhuhhhap...h..h.....t..p...........h...s....h..+.............h..h....h....h..t.h.h.....h...h..h.h.h.........l......t...h.s.....h........h............ls....st..hah.hh..t.hl.....phh..hthhPhhhh.........sphsP...u......E..ushauhhhuh.shu..h.ut.hu.h.l.thh..............hstt................aptl.hhlhht.h....hhsl.h......hl..........................tt..................................................................................................................................................................................................................................................................................................................................................................................	0	200	338	460
+103	PF00651	BTB		BTB/POZ domain	Bateman A, Bardwell VJ	anon	Prosite	Domain	The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer.  The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.48	0.72	-4.08	96	15670	2012-10-02 01:20:04	2003-04-07 12:59:11	26	989	511	79	10101	15120	88	105.10	20	20.57	CHANGED	hsp.pppt...hsDlslhlt.......pphpuH+slLuupSsYFpshFpsp.................tpts...........l.hpslssp..shptlLcah..Ysupl.h.............tpsltplLphA.phhpltslhptCpphlhpph	..............................................................h.pt....hs.D..ls.l..hlt...................tpph....sH......+...........s................l...............L...u....u...p.......S.s......a..F.....c..s...h..hpss........................................tcpp...........................tlp.l......p...s.......l......s.......s..p...........s...hp...t.l.....L..c...a..h.......Y...o....u...p...l.phs..................................tps....l...........p....l...l......t...s...A...p....hh......p..l......t..t..l.hphstphh....h.....................................................................	0	2968	4235	7306
+104	PF03437	BtpA		BtpA family	Finn RD	anon	Pfam-B_4453 (release 6.6)	Family	The BtpA protein is tightly associated with the thylakoid membranes, where it stabilises the reaction centre proteins of photosystem I.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.39	0.70	-5.13	6	562	2012-10-03 05:58:16	2003-04-07 12:59:11	10	3	505	0	178	689	382	246.50	36	93.56	CHANGED	pcKPlIGVVHLhPLPGSspasu...........sLstVID+Alp-Apslp-uGhDAlIlENaGDtPa.Kp.Vs.tTVuAMolIssclpp-VulPlGINVLRNDuluAhuIAhulsAcFIRVNlLoGsthoDpGIlEGsAtELh+h++hL....su+.lclLADVtVKHAhahus..lpsslhDTlER..uhADAVIloGpsTGucsDl--LchAKcsss...sPVllGSGVs.cNlpphhphADGhIlGThlK+sGph.N.lDh-Rspplschscc	...............................................................................................................................pKslI.uMlHLpsLPGsPtass...........shptll-+Ahc-htsLpsGGVDulhhpN.ashP.a.h..p..c.....l.t.scssuuMuhl...htpl..tp.p.l..p........l.P.....h.....GVNVLh.DshuuhslAhAssA.cFIR......p.ha.sG.sas.uD....Glh.-.sssu-hlRa...p+pl....s.As.pl+llh.slhsctu..sh..L...u..s........c..s..l..........s..p.h.s+.s.sh.p...stsDAlh...Vo...G...hs.sG..s....p....s....s.........t...........L....c....p.l..+csss..........tsPVl.ssoGV.s.h.-.N..l.pc...L.s.h..ADGsl...luos.h....Kc....c...G.hhtN.....................V...D.tRVppFMctlp.p...........................	0	60	104	151
+105	PF03131	bZIP_Maf		bZIP Maf transcription factor	Mifsud W, Eberhardt R	anon	Pfam-B_482 (release 6.5)	Family	Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.04	0.72	-3.69	15	969	2012-10-02 13:17:30	2003-04-07 12:59:11	12	8	158	8	512	2370	5	91.10	34	20.20	CHANGED	hSD-cLlohoVRELNRpL...+GhocEElh+LKQ+RRTLKNRGYApsCRhKRlpQ+csLcpc+scLppplcpLppEhuthppEpDulpt+hptLt	.......................................os-pllshsVc-h...NchL........ctLo..c-plthl.....+.p....hR...Rp..h...KNR..shAQs....CRp++l...pphppLE....p...-h.pp.......L.ppc.h-cLh.p.Ep....s.p.h.tp.phcth+p+hpth.h................................	0	105	151	298
+106	PF00168	C2		C2 domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.90	4.50	20.90	6.10	20.80	-999999.99	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.89	0.72	-4.14	382	23398	2012-10-10 12:23:49	2003-04-07 12:59:11	25	644	543	119	13594	21474	315	86.10	20	17.18	CHANGED	LplplhpApsL.shc..........................................hps..psDPYVplplts.......tp...........................h+Tcshcps..hNPhWs.....Epatap..h..sphpp......LplpVh.Dpcthst...............cchlGpsp	............................................................................................................................................ltlhpu....p...sL.....s.h.s....................................................................................hts....ts..D....P...a.l.p..l..p..lt.s...........pp......................................................................................t+T......c...s.....h....p.....p....s.....h.........s..P..h....as..............-.p..h..t.ap...h.............t.p.hpp.......................Lp.l.p...Vh....D..t..c.t.htt...................schlGph.t...............................................................	0	3560	5729	9404
+108	PF02743	Cache_1	Cache; 	Cache domain	Bateman A	anon	[1]	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.49	0.72	-4.42	19	6574	2012-10-01 23:40:40	2003-04-07 12:59:11	13	246	1855	16	2046	5858	159	78.30	20	11.74	CHANGED	lT-PYh-ss...........ssphVlThuhPlhs............ttphhGVluhDlslcsLhphhpplplGtpGYsFllstsGpllsHPspcshscpttt.	............................................................otsYh..s.t............................st..p..h..h..l..oh..u..t..P.l..hs.....................................................s.u.p.h..h...G...V....l..u....h....D..l....s....l....s........p....l....t...p....h....l...p....p.....h.......p..........h......s...p..s....G....a.s....h.l...l..s.....p.....s.....G.p..ll.s...+..sp.p.........h................................	1	687	1216	1644
+109	PF04857	CAF1		CAF1 family ribonuclease	Bateman A	anon	Pfam-B_1567 (release 7.5)	Family	The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 Swiss:P39008 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain Pfam:PF01424. This family of proteins is related to other exonucleases Pfam:PF00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 (Swiss:P39008) has been resolved at 2.3 Angstrom…resolution [3].	23.50	23.50	23.60	24.00	23.30	23.10	hmmbuild  -o /dev/null --hand HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.68	0.70	-5.06	27	1134	2012-10-03 01:22:09	2003-04-07 12:59:11	15	22	328	16	721	1069	11	271.30	26	67.58	CHANGED	pcVWppNhpcphphlpphlcphs...alAhDTEFsGllscshtp......htsss-.pYptL+pNVsthpllQlGLohh.....sppuphss..........shs.........................sapaNFp.Fshcp........chh.stcSIchLpppGhDFpcppcpGlshtphs.......................................................................................................................................................................................................................................................................................................phlhsSsllhst.p..lpWlsapusYDhuaLl+llp.s......tpLPppht-FhphlpthF.Pp....lYDlKhlhp..h..........................................................................hp...................ph....uLpclA-tLplpR.......................................................................................................sGp.tHpAGuDoLlTstsFhc	...................................................................................................................................................................................................-VhtpNhppp.hthlpp..h.l..p..phs....alAh........Ds.EFs..Gls....s..p..shst................htsss-.p.Y.p...t.l+p..s....s.c..hh.pl..lQlGlohh...............sppsphs..........t.hs...................................................................................sapFN.Fp...Fshpp.........................chh..stsSlph.Lt......p......p......G.h....s......Fpch..pp..G..Ishhphs..................................................................................................................................................................................................................................................................................................................phh.h..h.Ss.l..l.ht.......p.....h.h.h.lsa..p..uhhDh.salh+hhhs..............sLPps...t.pFhphl...phhF..Pt..........laDhKalhp..t......................................................................................................................................................................t.psuL.pplt..c.t.L.thpp...........................................................................................................................................................................................................................................s....HpAG.DuhhTu.sah........................................................................................................................................	0	236	379	557
+110	PF03135	CagE_TrbE_VirB		CagE, TrbE, VirB family, component of type IV transporter system	Mifsud W	anon	Pfam-B_843 (release 6.5)	Family	This family includes the Helicobacter pylori protein CagE  Swiss:Q48252, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system.  The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration [1]. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro [2]. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE Swiss:P54910 and VirB Swiss:P05353  proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. Homologues of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis Swiss:Q9RPY1.	20.50	20.50	20.60	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.95	0.71	-4.56	15	1506	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	797	0	316	1404	70	190.30	20	25.11	CHANGED	phLuphpp.psltas-lLpFhsphls.Gppp.shtlsps..hlDshls......uplhhscct...........hhhcpssp....ppasuhlul+-Y.sscopsshlsslLptchEhllhpoFshhs+ppupshlp...ppphhstscputspltclsptlcphsusphshGhap.olhlaAcshppLccpstcspstLpspGhlustEoluh-suaaupLPuNhphpsR	.....................................................................................................t.........pth.hsc.hpahphhls..sp.p...lhhspt....lsthls.......sphh..hstcp...............h...h.p..t.t.t......................ppasshl.s.lp....p.Y.s.phpsshhsh.hh......t........h.........s......h...p...hhhhpsa....p...hhs.......ppp....s..................hsh....lp...t....................p.............p...p.....................hh..............p....h....................s.................s.....s...u....ts...p......h....................t.-.hs.p......ul..p..p.lss..sph.s.h.G.a....pholh............lh..............u.......c....s............h....c.....plcppspts.t.sh.l...p.s...t.G....hhs..h.h-..sls.h.s..u..aauplPuphhhp.R......................................	0	58	171	237
+111	PF02515	CoA_transf_3	CAIB-BAIF;	CoA-transferase family III	Mian N, Bateman A, Heider J	anon	Pfam-B_887 (release 5.4)	Family	CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	20.70	20.70	20.70	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.21	0.71	-5.06	118	8297	2009-01-15 18:05:59	2003-04-07 12:59:11	12	30	2042	90	3017	7416	4895	185.50	29	47.03	CHANGED	lsLDL+sspG+tlhpcLlp....pADVllcNh+PGshc+lGLsh...csLc....phN.....PcLlhsuloGaG.p....sG..Phss..psuaDh.shpAhoGl.....hsh.s..........sss.s...P.hhsuhs..lsDhsu.uhhuuh...ulLAALh....pRp..c.oGp..Gph....l-lohh-s.shth.hs.hhhthhts.s.th.t..........Gstp...........sssssh..shaps....tDG.......alsl..u.shssphWpth	.................................................lsLDL+..s..scGpphht.cLl.t..............pA....D....Vll..EN..a+....P.G..sh.....c.+..h.Glsh......-.s.Lp......th..N.........P.+....Lla..ss.l.o.GaG..p............s.G.....P.h.ss....p.s..u......a.............Dh.l.h..p.A.h.uGh...........................hsh..s........G...........................ss....s...............P...h.....h.su...ss...........lu.D...hss.G.h.h.ush...ulL.u....ALh..............pRp......c......o........G.....c..............G.....ph..............lDsuhh-s...shs..h........h.t............h..h..h....t...h..h..t..s..u....t.st................t.h.................uttp.........................sshssh...ssaps...............tD..G...............hlhl..u...shpst..at..............................................................................	0	656	1710	2447
+112	PF02888	CaMBD		Calmodulin binding domain	Bateman A	anon	Psi-blast P70604/413-489	Family	Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM) [1]. CaM binds to the SK channel through this the CaM-binding domain (CaMBD), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca2+ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known [1]. This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other.	25.00	25.00	28.80	28.10	23.70	22.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.63	0.72	-4.17	5	334	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	83	7	163	297	0	74.40	61	13.92	CHANGED	DoQLTKEhKNAAAsVLQETWhIY....KHT+h.p+t-ppRlRKHQRKFLpAIHp...FRoVKhEpRKlsEQsNohsDluKs+pl	............DTQLTKR.lK.NAAANVLRETWLIY....KaT+Ll.......KKhDpu+VR+HQRKFLpA.I..Hp........LRpVKh-QRKLsDQANTLVDluKhQsl....................	0	31	45	98
+113	PF01302	CAP_GLY		CAP-Gly domain	Bateman A, Finn RD	anon	Prosite	Domain	Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein Swiss:Q20728 CAP-Gly domain was recently solved [2]. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove [2].	24.90	24.90	25.10	24.90	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.56	0.72	-4.27	146	2400	2009-09-10 15:43:18	2003-04-07 12:59:11	20	120	319	45	1448	2206	31	68.20	38	10.48	CHANGED	lG.pRl.pl...........tstthGsl+a......lG.psp.hss............................G.............h......WlGlEh.Dp....s....h.....GK....NDGo..l.pGh+YF..pC........p.sp.....tGhFl+spplp	...................................lGsRV.l............ssschGsl+a......lG...tsp.hss....................................G................h......WsGVEL..Dc.....P....t.............GK...................NDGo........V......p.........G......h+....YF..pC...........p..sp......tGlFspss+l.p..............................	0	487	694	1078
+114	PF01039	Carboxyl_trans		Carboxyl transferase domain	Finn RD, Bateman A	anon	Pfam-B_299 (release 3.0)	Family	All of the members in this family are biotin dependent carboxylases.  The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognised types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide.  All of the members in this family utilise acyl-CoA as the acceptor molecule.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	493	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.40	0.70	-6.15	34	11662	2012-10-02 13:07:06	2003-04-07 12:59:11	17	72	5959	146	2951	11205	7464	323.30	27	68.57	CHANGED	tpascG+hssc-Rl-lll-sGS.Fsph-shhtpcssphuh...c..hPssullTGhGsltGptshlhupDhsshGGshushputK...lsch.chAlps...............GtPhlslsDuuGA....c.t-GVpsLpGhGpIFtpsspASu.sIPpIollhGsssGGuuY.PuLsDhslhVcs.tuhhalTGPsllc..............pVhG..EphospphGGuptHhtpoGluHhsupsD.-ulphl+chlSalP...sst.......ssPlhtshDssc+..............shlPss.ppsYDsRplIptlsD.............pupFhEhpssaApslVsGhARlsGhsVGllANpsp......................AG.sL..cSu.KsAcFlchCss.hslPllhLsshsGFhsGpcpEasGIl+aGAKllhAhucusVPtlolIst..cuaGGualVMsupthsschh...huassAcluVMGscGAssIlaRcchttts.........p.pth....................hppphtchccphsssYhssuptasDsllcPschRs+lshshphhhpcpt.hh.h+p+tpl	.......................................................................................................................................................c..................p....h...................h...............t.....................................h...........t............................t.............................t......t....................................ssul....l.sG....h...G....p....l......p.............G.......h...................s.......h.l.hs.....D..hs.............hh.uGo.hush.sucK..........ls+hh-hAhpp...................................p.h.P.l..l.hl..s.s..S.GG.........A.......R...........h.....Q.......E............u......hh..............u......L.......h..............t...h..u..+...l..............t......s.........t..p.....h..p...........t..t...........ls.I.o.l....l.h.sP..s..sG..G..s.A...h.s..h......h.s..D.......h.......h.......lh..p.....uhl.hhsGPcVl.c...............................p.s..h....s......E......h........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	955	1849	2497
+115	PF00755	Carn_acyltransf		Choline/Carnitine o-acyltransferase	Bateman A	anon	Pfam-B_438 (release 2.1)	Family	\N	19.40	19.40	20.50	19.40	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	591	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.77	0.70	-6.43	17	1813	2012-10-02 12:01:53	2003-04-07 12:59:11	15	34	362	41	1101	1697	26	442.50	26	79.93	CHANGED	sLP+LPVPsLpcTls+YLc.ulcPlhs-.-paccopplspcFss...shGppLQchLhphuttp......sNWlscaWhphhYLphR.hPlslNSs.h..sshsph.hpsp.........psQhtpAuplhpshlpahptlcpcpl...........sphhtG....................ttPlsMsQapplFsosRl...PGhp...pDslhphtcsc.......HllVlp+spaaplclhcs..suphlo.s-ltpQLppIhppupp.psh.tsluhLTopsRspWApsRptLhpsss..NpcsLctI-pulFslsLDcs..................pss.cs....t..hphh.........htss.p...ssutNRWaDKohphllspsGpsGhshEHossDGhsllplh-h.h.hspphhc......................phhts.s......lshPp+Lpaplssp.hpspIpputpphpthhs-L-lhshpFpsaGKshlKp.pplSPDuFIQlAlQLAaY+.haG+hssTYEoAosRhFtcGRTETlRosos-uhcFVpuM...........s..sstott-.............+hpLhpcAsppHsphhcpshpGpGlDRHLhuLphlupt.....pslphP..c...hahcpsathu...sshhlS.....os..plssphhhhhs...aGPVssDGYGlsYphp.ppplhhslSuapSsspTsup+asphLpcAhp-hts	..........................................................................................................................................................LP.p.lPlP.lppThp...pa.lt..shps..l..........h........s...................p..............p..............h..............t......p..........h..........pt...h....sppF.t.......................t.u.........LpthL....ht....t.........................psa.........l..............t....p....hW.p.......h.h....ht....c.........sl.hss..............h.........................................................t...t....h..h.uuth.h..s.h...h..ah..t..lcpttl..........................s.h.hht...............................................Phs.tpa.h...hFsssRl...P...t.t........tD.h..t.......tsp......................HlhVhpps.pha..hh...h..ht.................s...p........h..p.......tpl.....p....hp........l...h...........p....t..s.t.....................................................t..........................lu.hLTst....tRs....Wu.ph+p....hh.t...tt.......NtpsL.p.h.lcp.uhhhlsLDp.............................t.t...............................................tt.h.h......tp.s...hsRWaDK....s.hp...h.ll...tsG...............p.h.uh..hEH.s.....h.Du..hhphh...p.hh..........t...........................................t.t................s.s..ptl.pa..p.....hs..t........h..t........lt.......u.....t.th.t..t.hhpphp.h.h..h...a.t.t.......a.G..+.t..h..hKp...th..S.PDuhlQhs..hQ.hAa.a.p........h.s........p......................sY..Ess.h+hFhpGR.T-.....sh..R.sso.pshta...sps..h..................................................p.......t...s...tp.............................................................................hhthhptAhptH..th.h..t......s.....GtGhDRHLhsLh.h.t...............................................t....P.....t................h......s.......ath.......tp..h.p...................hs...........ph.s.s...h.......h...h...s....a.us.................s...................pG..aG..hsY......p...h...hthssh........................h..pst......th...l.t.h.ph.........................................................................................................................	1	386	559	894
+116	PF03378	CAS_CSE1		CAS/CSE protein, C-terminus	Mifsud W	anon	Pfam-B_3786 (release 6.6)	Family	Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1 [1]. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation [2,3]. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation.  Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle [3], as is the protein MEK, which is thought to regulate the intracellular localisation (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway [4]. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins [4]. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins [5].	19.60	19.60	19.60	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.31	0.70	-6.18	16	387	2012-10-11 20:00:58	2003-04-07 12:59:11	10	14	287	3	271	370	12	387.00	29	44.71	CHANGED	ERlLhlpcsssp.slhsss-lsPhsppLLspLFphlphssS....pENEalMKClMRVLhllp-ullPh.ssslLs+LssIhphluKNPSNP+FtaYhFEulushlRhsspusss...sFEpuLaPsFssILppDVp.....................EFhPYV.........FQlhu......tLLEhss.ssslPs.sYhsLhsslL..................sPshWEppGNlPuLlRLLpAhIt+uuppI..sssspLpslLGIFQKLluSKs.sDppGF.LLpullpphPssslp.YhtpIhpllFpRLQsSKTs+FhpphlhFhphhss+p.....GushhIphh-slQsslFs.lh.plllP-hpKlutsl-RKlssluhTKhL.sEo.Ahhsp.YtKhWuhhhpuLlpLhchPspsss....c--hls.tDss.hGassuFopLssstpptcDPhP-..lsDsKhalup.LpchsptpsG+lsshlsppLss-uppsLtpY	...............................................................................E+lhhh...p...t..s....t..tt...l....h.stscl.tPhs.p.LLppLFphl.ph.sso...............tENEalM+..slMRs.h.hhp........-sh.h..sh.hs.sllsp.Lhp.......hl.thls+N....PS.pPcFsHYhFEuluhh.....l+..h.ssp...s...ss.s..h.....phEps..LassFp.tILppDVp.....................EFhPYl..............FQ...lhu......hLLEh...p..................s......sl........P.p.sYhsLhs.LL..........................p.P.slW..-.pp.G....Nl.PuLlRLLpuhlp+ss..ptl..............ht..t..s.pltslLGlF.Q.+LluoKs...s-....pt...GF........LLpslltph...s...p...lp...a...h.tp.IhhllhpR.L.Q.s....u....+T...s.......c..ahpphl.hF..hs..hhshph.....................usshllphh.-.pl...Q....s..t............hFs.lhp...pl...h...lP....ph..p.p..l....................s.t...h...-.+Klssluho+hL..s.p.s.....h.hs....p.....h.tphWs...hhpuLlt...lhp...........s............t.s.sh...................pcc...h.........h..s....t.............-.s.....................u.......a.ts.u.......aspLshst.t.t..h..Dshsp....l...t...s...sp..alsp...Ltphs.tt.p.s.sth.thht..h...................................................................................	0	103	159	224
+117	PF00690	Cation_ATPase_N	Na_K_ATPase_N; 	Cation transporter/ATPase, N-terminus	Bateman A, Griffiths-Jones SR	anon	Pfam-B_138 (release 2.1)	Domain	Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.10	0.72	-4.51	168	9625	2009-01-15 18:05:59	2003-04-07 12:59:11	21	104	3314	73	3641	8446	271	66.10	25	7.18	CHANGED	hpphsscplhppL.......p.ss.......ppGL.op....ppsppRh....ppaG.Nplt.ptctpshhthhlppa.psshlllLlhuullS	...............................................s.pplhpph.................p...s......................ppG....L...os...............p-s......p....c..Rh.................ppa.G.....N.........p..l......s...tpc.....tpsh.......hh..hhhpp.a.ps..shh.h...lLhhuAllS...................................	0	1148	2096	2947
+118	PF01545	Cation_efflux		Cation efflux family	Bateman A	anon	Pfam-B_232 (release 4.0)	Family	Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.	22.80	22.80	22.80	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.80	0.70	-5.34	89	12806	2012-10-02 19:55:49	2003-04-07 12:59:11	16	54	4824	10	4122	10055	1117	268.50	19	81.33	CHANGED	lhlulhhshh.hslhclhsuhhs.sShulluDuhashhDhhuthlslhuhphu...................p+.sssppa.......sa..Gat+hEslsulhsulhllhh.uhhhhhp....ulpphlps....................tphphshh.hhh...................h.sllu.....lslshhhhhhhpp.......................................................................................................................................hp..ots....l.pusthchhs...Dshso....luslluhllhhhh.......................hhh..................hDslsulllulhllhsuhplh+puht.Llsts.sssthh...pplpphl...........hsslh.slpcl+hhphGs...phhlslplp.hsssh...shpphcp..........ltpplcptlppphstltp...h..lp.hpsttptp	....................................................................................................h.hhuhhhshh.hh.lhch...h...s...u...h...hs...s.......ShulluDuhc.lsDh............hu.hl.............s..lh..u..h......phu...............................................................p+...s.s....s.tpa.......................sa...........Ga......t.+......hEh.l.uuhhs.u.l.........h..lh..hh..u...h.h.l.lh.c.......ulp+.l...hps.................................................................ptlp.ss...hh...hhh............................................................................uhlu........ll.s...s..h.h..hhhhhtc.......................................................................................................................................................................................................................................................................................t......................................................................................................................................hp...s.s.......l...p...ush..h..c..hhs....Ds.lso....................luslluhllhhhs.........................................................shhh..........................................hDslhulllul.hllh.s..uhplh..pc...uhphLhpt...s....st....ph..........................ppl.p.phl.p.........................hstlh...s.l...c..c..l..+..s.h.......p..hus...........phhhsh+l....h.s..sph...............h..ph.pt.........................................lhpplpp.hl.....tp.p.h......t.lt.t....hh.lp..h-.....t..........................................................................................................................................	1	1327	2487	3430
+119	PF04586	Peptidase_U35	Caudo_protease; 	Caudovirus prohead protease	Waterfield DI, Finn RD	anon	Pfam-B_4836 (release 7.5)	Family	Family of Caudovirus prohead proteases also found in a number of bacteria possibly as the result of horizontal transfer. 	20.70	20.70	20.80	20.90	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.00	0.71	-4.22	36	1699	2012-10-01 19:43:34	2003-04-07 12:59:11	12	10	1302	0	286	1376	536	154.10	23	52.03	CHANGED	psh-l+stp...pst.....lpGYAshFsp.sp.........htEhltsGAFspsLtp.ts....lhhLasHDt.sp.slGpsps.........cLppDspGLchchcl..sssstuc-l.hphl+pGslsuhShGFpsh.....ppphptps.........hRplpcl-.Lh..ElSlVoh.PAhscuplp......tpshpphtph	............................................................................t.....p..t........tt...hhhpGaushas....s.................ht-hlt.s.sA.h.p..tsh.tp...s..........lhhLa.......pH........c..........s.........p.........s...l...Gpsp...........pl.p.......D.......spG.L.hhcsch.......ss.......s.....s.......tuc-h...h...t...t...l..+....s..G...s.l.suh..S..hGFpst...............p.phppss.......................t........hpplpchc.Lh..ElSl...V..o...h...PA..spsplp......hpt......t..........................................	0	81	174	230
+120	PF01607	CBM_14	Chitin_bind_2; 	Chitin binding Peritrophin-A domain	Tellam RL, Hutter H, Bateman A	anon	[1]	Domain	This domain is called the Peritrophin-A domain and is found in chitin binding proteins particularly peritrophic matrix proteins of insects and animal chitinases. Copies of the domain are also found in some baculoviruses. Relevant references that describe proteins with this domain include [1-3]. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.46	0.72	-4.04	209	6920	2012-10-01 20:20:38	2003-04-07 12:59:11	19	153	308	1	4290	7189	6	53.80	23	23.27	CHANGED	Cst..........tsGhhss......ssC.spa.hhCt......supsh.......hhpCssG.hhFst.....ptptCshspp.........spC	.............................C..........tu.h.hsp......spsC...spa.ahCh.........s.G.p.sh................hhpC.s........s........G........h......hF...st...................ptp...t....Cshspp..........tC.......................	0	1391	1754	3585
+121	PF00942	CBM_3	Cellulose_bind; CBD_3; 	Cellulose binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1126 (release 3.0)	Domain	\N	20.60	20.60	20.70	20.80	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-9.79	0.72	-3.96	29	651	2012-10-01 21:34:18	2003-04-07 12:59:11	13	120	165	35	192	639	2	83.10	27	12.10	CHANGED	l.hcsusss.ussNtlcs+hplpN.oGssuhsLsclplRYaash-t.thstsahsc.sslu.........susl.hshsphss.ssu.ssaYlEls	................h.hpsssss..sssspIpsphplhN.oGssslsLsclplRYaash-.t..st...s.tshs..sDauplu..............su..sl.p.....tp.hsp.lpsstss..AshYlElu............................	0	101	152	164
+122	PF02018	CBM_4_9	CBD_6; CBM_4; 	Carbohydrate binding domain	Bateman A	anon	Chris Ponting	Domain	This family includes diverse carbohydrate binding domains.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.94	0.71	-4.14	47	1727	2012-10-03 19:46:52	2003-04-07 12:59:11	12	250	613	41	590	1782	213	134.50	15	21.89	CHANGED	sshlhsssFEs...................shssWtspsss.............ssssss.....sGphslplsspss.....sasuhhhphs..stlppGpsYplShhsptsss........pplplplphpss.........shpthts......thshs.spWpplpss.aThs...sssssshlhlps..........ssss	...........................................................................thl.NssF-p..............................sh.ss...Wp..s....hs.ss...........................sshsss..................sGs..h.s..l..t....l......s...s...tss..........shss...h..h.h.p..hs....hslp..t....Gp.s.YplShhs+ssss.................tplplplptsss...................htth.ts...............tsshs..spWpp.h..p.hs.ashs.....ssssps.lhht.......sts..............................................................	0	271	468	540
+123	PF03422	CBM_6		Carbohydrate binding module (family 6)	Bateman A	anon	Pfam-B_1231 (release 6.6)	Family	\N	21.00	21.00	21.20	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.65	0.71	-3.97	41	1755	2012-10-03 19:46:52	2003-04-07 12:59:11	10	402	465	60	713	1810	331	121.80	21	17.74	CHANGED	cAEsastt..uGlshpppss..t.....sGhslshhssG-Wlsast..lchssuushphp.spVAsssus...usl-lclsu.....suslluolsl.ss.TGuWpsa.......tsspsslshss.Gs+slhLshsust......hhNlDahpFsp	...........................................................ht.......t.u.hphtspst....t...........sGhsl...u..h...h.p.s...G....-..a..l..pas....Vs.hs...s..u...u..s......h.....s.hp..h.+s..A.ss.sss...........uslpl.p.lsu...............ss.h.l...u..s.hs.l...s......s.....TGu.......W.p....s..a......................ps.h..s..s.s..l..s..hss...G.s.p.s..lhlhhsuss............hNlDhhph...........................................	0	338	629	686
+124	PF00571	CBS		CBS domain	Bateman A	anon	[1]	Domain	CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5].  CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5].	24.00	16.50	24.00	16.50	23.90	16.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.50	0.72	-4.16	850	77225	2010-01-08 14:28:41	2003-04-07 12:59:11	23	464	5124	378	23594	56987	15502	57.10	19	26.04	CHANGED	lpcl..hsp..............sshs..ls.s....sslp.cshp..hht.....cpp......hp.tls.V.....ls......cp...........scll..Gl.lohpDllpthht	............................................................................th.hp.................phhs....ls.s..........tslp..cshp.....hhp...........................cpp............................hptlsV.......................ls.......................................-p.............................spll.....GllohcDlhp....t........................................	0	7547	14981	19849
+125	PF02754	CCG	DUF224; 	Cysteine-rich domain	Bateman A	anon	Bateman A	Family	The key element of this family is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins [2]. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster [2]. The family includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase [1] Swiss:P52074 and glycerol-3-phosphate dehydrogenase.	20.60	11.80	20.60	11.80	20.50	11.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.31	0.72	-3.98	61	13777	2009-01-15 18:05:59	2003-04-07 12:59:11	11	93	2942	0	4139	10623	3794	86.00	20	33.05	CHANGED	lsaasuC..hhcst........h.pstphhtplhshhshch.h..ptptCCGusuhhsst...pt......huh....plsppplpphpc...h.s.....s-hllssCssChhplc	...........................................lsaassC...hhchh...........................ttps.t.p.s.h..t...p.l.h...t..t...t........s..h.....c.....l...h.....h............t.....t....p...t....C...C.Gt.su.t.h..s.sp..............pt.........hup..............ph..s.pp....p.l....c....t.h.pp...............t...t...........................sc..h..l..lsss..s.s.Chhtl.t.......................................................	1	1454	2943	3646
+126	PF03379	CcmB		CcmB protein	Mifsud W	anon	Pfam-B_3059 (release 6.6)	Family	CcmB is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. CcmB is required for the export of haem to the periplasm.	23.10	23.10	23.10	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.43	0.70	-5.13	13	1869	2012-10-03 10:13:34	2003-04-07 12:59:11	8	2	1817	0	379	1383	1059	208.50	38	96.40	CHANGED	hhsllpR-L+lAhRssushhssLhFFLlVlsLhPlulGP-splLuRIAPGIlWluALLusLLuL-RlFtsDaEDGSL-...lhhsshPLthllluKshAHWllTGLPLllsuPLhuLLLsLshsuassLhhTLLLGTPsLShlGulGuALTVGL+RGG..lLLuLLlLPLhIPlLIFusuAlpsuuhs...hshss.hhlLuuhhlsslsLuPFAsAAALRl	..................................................................htlhth-Lpluh..R...p...tuplh....ssLhFF.Ll.V....Is..L.F.PL...u..l....G....P......-.......s..p.....L.......L........s..+...lu.PGll.......W.luALL.uuL.L...u.L..-RL.FR.....sDhpDG..oLEp..lhL...t..s..hP..........L..s.hllLuKlhA...H...W....l.lo.G.L..P.L.ll.lu.P.l..l..u.l.h.L...s.....h.....s...s..t....u....h....t....h....h....h.L....o..L.L..L...G.T..P.s.L.u.h..lG.AlGsA.LTlGL++G.G....lL...Lul..LlLP.L.hlPlLIFu.su...Ahsuushs......hshs...u.......L....t.l....LuAhhhh....s....h.s.L.s.PhAhuuuL+........................................................	0	109	232	305
+127	PF04103	CD20		CD20-like family	Bateman A, Moxon SJ, Pollington J, Finn RD	anon	Pfam-B_1979 (rel 7.3), Pfam-B_10092 (rel 9.0)	Family	This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm [1]. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts [2]. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton [3].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.79	0.71	-4.28	80	1022	2012-10-02 01:14:40	2003-04-07 12:59:11	10	9	113	4	533	1008	0	133.70	19	47.50	CHANGED	sLGsl...QIhlGlhplslG..hlhhhhh.s.........hhhhsGhPaWuulhalluGsLu.lsuppcss....phllpsslshNllSslsAhsulllhshslthtp.hhth.........................................tshhhstph.......htulhsslLlhslLphhlulshshhss	........................................LGhh...QlhlGlhhh.sh.G...hh.h.hh.h.hs..................hhht.uh.sh.W.u..uh..h..hll.uG.lu.lhs.....tppsp...........phh.hp..s.phshs.l.lus.hh..u.h.......s........uhhlh..shsh......th.t.h.............................................................................................................................h..............hhsl.hhhh.hhshlphhlsh..shh....................................................................................	0	125	173	258
+128	PF05179	CDC73	Cdc73; 	RNA pol II accessory factor, Cdc73 family	Wood V, Bateman A	anon	Pfam-B_6394 (release 7.7)	Family	\N	25.00	25.00	25.70	27.20	22.40	24.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.79	0.70	-5.04	6	336	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	288	1	245	334	3	259.70	26	58.02	CHANGED	Tcsplhlpstchh.thslhshhpuspspp-.s+sp.ssss.sostscc.plctpptp..upaspaspcphss..p.scthcIsshGSh+GssLsulcpG...........................h.....ssupu+tstss.suK+ssRsPIIllPSAsoSLIThhNlK-hLp-hpaVP..sst++tpGsp+ssplslQ++psp.p........ThsacVlDsspKLp.P--WDRVVAVFVhG.sWQFKsW.W...s.sPs-IFs+IpuFal+aspD..cssssVppWNVchlplSpsKRHhDRsVhpphWEoLE+altp+	........................................................................................................................................................................................................................................................................................t........................................h.st.hh..t.........t...htthp..s.shup....h...t.t....s....h........hppt..........................................................................h.....s.s.t..s..t.....sp...p.........t.......p.....p.t.p....p..s..PI...I...lls.s..u..s........o..S..LlshhNsKp..hL.p-..tp..a.ls........spp..t...p...t....p.........s....s...t...p.p..s.l.h........lp..+......p.h.p.ph..............................shp...ah...lV..Ds..s...t.ph..........p.....s...........c.WsRVVAVF..sp.....Gts...W...QFKsa....W.........s.s.P.....s.....-lFp+...........lpGaalpacsp.......phstp.V..ppW.................s..Vphl..p..l.......sc................p..K...............RahD+tsh.pFWcpl-.chhh.............................	0	84	131	200
+129	PF01066	CDP-OH_P_transf		CDP-alcohol phosphatidyltransferase	Finn RD, Bateman A	anon	Pfam-B_651 (release 3.0)	Family	All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.44	0.72	-3.71	124	11822	2009-01-15 18:05:59	2003-04-07 12:59:11	16	43	4879	0	3729	8699	4901	147.30	20	63.29	CHANGED	hhhhPNh..lT...h....hslhh.uhhsshhhhhs.....ph..........................................hhushhhhlshlhDslDGtlARthspsSt....hGthlDshsD........thshshhh....................................................................hslhhhhshhhsshhhhhhht	.............................................................h...hPNhlT.l....hp.lhh.....s...h.h..h.hh.hh.hs.....th..................................................................................................hhusllhhlusl...hDhl.....DGhlAR....p.h..s.t.s..op............hGthLDs..luD.....plh.hs..sshhhhh.........................................................................................................h.h...............................hhhhhhhhhhhhh..........................................................................................................................................................................................................................................................	0	1273	2397	3165
+130	PF00150	Cellulase	cellulase; 	Cellulase (glycosyl hydrolase family 5)	Sonnhammer ELL	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.05	0.70	-5.20	65	5309	2012-10-03 05:44:19	2003-04-07 12:59:11	13	205	1466	165	2106	7158	527	265.90	14	56.85	CHANGED	lstsGpsh.....phhGhsst.........W..tsth.....stpshhphhpshGhNslRlshs......h.........ssah.....s.s.sh........s.......thhsclcpllshu.hspGhYl.IlDhHp........................................ts.tsshss............spsh................Fpp..........h..lAs+a...ssss.pllaE..lhNEPps.st..........stW...............stlpshsppslssIRss.uss...phIllsssp..............................Wus..........ssst.shs.......P..................ts..........tsplhaohHhYs.ssphs.t....................................................spthpsthphh.hspGh.slhluEaGss.....ssss.................tspsstW......lshh......ppp.slshsh.Wshssps	...........................................................................................................................................h.............................................................pp.h.p...h.h....p..s....hG.h.shl.R.l..s.ht.........................................h.................tth.........................t..sh.....................................hst........................................s.h.h.p..t...l..c..p........h...l.p.h......s...pp..t...G..l..h....l.....l...l.....-....h....Hs.................................................h.......................................................t..t.............t.....p.......tt...............................st.ph.............................................................................ht.p.............................h.h....p....t....l....u....p........p........a................s.....p.....s...s....hl.......h........a.-...l.hN....E...Pts........................................................................t..h...t....t.h..h....p...phh...p..t..l+..........t...h....s.sp.........thl....hl..s...s....t..............................................................................ast.................................t.t......hhp................P.....................................t.p..h.h.....h......s.h.H.....Y....s.................................................................................................................t.t.......h.p..t..h...h....t.......h.......h..p..t...s......h....s...h...hls..E......aGh......................t.......................................h....................ht.h...................t.......................h......t...................................................................................................................................................................................................................................	0	829	1465	1881
+131	PF04218	CENP-B_N		CENP-B N-terminal DNA-binding domain	Bateman A	anon	Bateman A	Domain	Centromere Protein B (CENP-B) is a DNA-binding protein localised to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.33	0.72	-4.54	6	534	2012-10-04 14:01:11	2003-04-07 12:59:11	8	19	145	3	370	898	32	51.80	26	11.42	CHANGED	++pRssLThcEKlclIpphE-sp..S+sslA+caslstoTlpsIlcpKcplLpth	..........................p.+ps..Lolc-Klcll.pp.l..-p.Gp......s.pspluccaGl.scoTlps.lhK.s.+cclh...h..............	1	79	158	248
+132	PF04734	Ceramidase_alk		Neutral/alkaline non-lysosomal ceramidase	Mifsud W	anon	Pfam-B_3385 (release 7.5)	Family	This family represents a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes [1,2,3].	19.40	19.40	19.40	19.50	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	674	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.05	0.70	-6.65	42	810	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	474	3	419	771	118	444.80	26	82.17	CHANGED	sYllGsGpADITGPssElshhGYAshpQhusGl+pRlauRAFIlu..ppss.........pRhValshDsshhspuV+hsVLctLps..phs.shYscpNVslouTHoHuGPGGahpYhLhpl.....oohGFscpsapAlV-GIlhSIp+AHpsLp....PGplhhups-ltsAslNRSshAY.sNPpcERupY......stsVDKphTlL+hsc.ssspslGslsWFuVHsTSMsssNpLlSGDNKGhAAalaEcphp.....................................................................sp.ss.tssFVAuFuQoNsGDsSPNlhGshC.p.oG..Cph.pSoCs.utsthChupGP..tt..sthcSsplIGc+QaptAppLas.....susp.lsGs..VcshHtalDhsshshs..........sthssss..h+TCsAAhGaSFAAG.ToDGP........G................h....FsFsQuss....pssP.............hWphlpshl..t.PotcpppCQtPKPI..LLssGphs.PYsWsPsIlslQllRlGpLhllusPuEhTTMuGRRhRcsltsshtssh................p.pVVluGhuNsYupYlsT.EEYslQRYEGASTLaGPaTLsAYhp.htphhsuLssu......tss....ssGP......pPPs.p.scplohhsuV.laDstPhspsFGDVhsp..ssss.YphG.-s.VsssFhuuNPRN..sL+p-sTahtVE+hp...................tsssWpsVtsDsDWshhacWc.......Rsssh.s..tScsTlpWpI.........PpsstsGsYRl+aaG.shKshhsu....lpsapGsopsFpVt	..................................................................................................hGhshhDhT...s.........h..thshhG.Y..up......p.ph..s..tGlcp+lhuRualht........tt.....................tp+hlh.ls.hDhhhh......p.....t.....lp.....tlhp.p.ltt.......tht.s..a..p..pp...sl...hlsuTHoHu.u......P......u....u..h....h....t.....h.h..h.th.........s.t.....u...a...p.t..........h..p.h.l.V.s.u.....lh...pul.pApps..lt..........s.upl.h.sp.s..............pl....s...ss..h.N.R.......s.........................s....a...........t....NP........t...pt.tth.......................ttssDtphshlph.p.......ss....p.....h.Ghl..sa.ass.Hs....s.s..h.t......s.s......s...p.....hlouD...hG.h.sshhhEp.ht.......................................................................................................................................................................h.......up.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s................................................................................................................................	1	157	259	363
+133	PF03859	CG-1		CG-1 domain	Bouche N, Bateman A	anon	Pfam-B_18451 (Release 7.1)	Domain	CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein [1]. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs [2].	23.10	23.10	23.80	30.40	22.80	22.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.57	0.71	-4.56	15	270	2009-09-10 19:07:15	2003-04-07 12:59:11	11	34	93	0	157	282	2	111.00	51	10.85	CHANGED	lhpEs+pRWL+sp............ElhtILt..sac+athh...pssp+PtSGSlhLasRKVlRhFRKDGHsW+KKKDGKTl+EAHE+LKVGs...................l-sLpCYYAHu..-psssFpRRsYWLLppshpcIVLVHYhcVp	........................................h...p.phRW.psp............EIsthLh....saccap...h.....pP.sRPt............sGSlhLasRKhl+..aRK.DGasW+K+KDGKT...s+EsH.KLKVtu...................h-s..LashYsHu......p.sPsFpRRsYWLLp.ps..cIVLVHYhpV..............................	0	32	82	120
+134	PF00307	CH	actinin-binding; 	Calponin homology (CH) domain	Finn RD	anon	Prosite	Domain	The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1].  The CH domain is involved in actin binding in some members of the family.  However in calponins there is evidence that the CH domain is not involved in its actin binding activity [4].  Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin and Swiss:P15498 have only a single copy.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.54	0.72	-4.01	194	10780	2012-10-03 10:10:54	2003-04-07 12:59:11	26	564	496	152	5898	10465	47	104.80	20	12.85	CHANGED	ccshlpWls.ptht..t....................................................................th.tlp.......sh.tpslpDGhhLspLlctl.pP...ph.........h.shppl..........p...........pphcNhphslp...hspc.hGhshhh........sspDlh.....pss.p........llshlhplhphht	................................................................................................................................................................................................pthhpWhp.ptht....t..................................................................................................th.plp.................sh..tpsh.p......D.G.hsL..s..tL....l....c.t..l...p.P.....sh........................................l..s.h.ppl..................................................p..................p...thc.Nl..p.h.slp...............hsc......p..........h.Gl.phhh...............sscDls............css.p.............llshlhplhth..t..............................................................................................	0	1688	2487	4051
+135	PF04420	CHD5		CHD5-like protein	Bateman A, Wood V, Mistry J	anon	Wood V	Family	Members of this family are probably coiled-coil proteins that are similar to the CHD5 (Congenital heart disease 5) protein. In Saccharomyces cerevisiae this protein localises to the ER and is thought to play a homeostatic role [2].	29.30	29.30	30.00	29.50	28.70	29.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.77	0.71	-4.57	27	271	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	233	14	174	269	0	152.20	27	75.98	CHANGED	lhslFhl.lhphLlsshtsutlspllhhhh.t.......spphpptpphpcElhpl+pEhsshSuQDcaAKWsKLpRch-Klpp-lcphspplsuppsphcthlphhhhlhssshhhhLphaatKsPlahLP...pshhPhhlchllu.....hPpushG..........................uVSlshWhhssss	.................................lhhh.lhh.llssh.ss...hlsphl..h..........ppssppppph+tEltph+cEhssl...Ss...tD...EFA+aA...K...L...cR+hsKhpccLcs...........hspphsuppsphchhlshshhlhpsshhhhLhhhat.psPlhhlP...psah..h.lphllu........FPpsshG........................uVulssWhhsCt........................................	1	44	83	135
+136	PF03067	Chitin_bind_3		Chitin binding domain	Bateman A	anon	Pfam-B_2364 (release 6.4)	Domain	This domain is found associated with a wide variety of cellulose binding domain. This domain however is a chitin binding domain. This domain is found in isolation in baculoviral spheroidins and spindolins, protein of unknown function.	21.20	21.20	21.40	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.76	0.71	-4.02	128	1556	2010-01-08 15:51:16	2003-04-07 12:59:11	10	34	838	15	481	1278	28	176.70	28	53.03	CHANGED	HGalpp.....PsuRshhCth.ss....................t....t...............................tsu.sspap.psh.Eusts..............h.pts.s..........DGplCuA.Gs.........s...phss....lD.ts...ss.pWtps...sl..........pssts..hshpaphT.AsH..tsshacaalT...Kssasssps..LshssL-hh.sh.........tt.t...........ts...ssstpa....ssslPp.......RsGppVlhshWphu...Dsss...................uFYsCsDVs	...............................................................................HGalpp.....P.s.SRshhCt.sss.......................................................s.....psG...ssta.ps..pul.Eusts...........................h.tts..s.......DGplsuu.Gs................t........thss.L.D.tps....us...cW.h+s..sl......................psG.s......hshpWphT...As..H....ts........upacaY.l..T........Kssa....s...s...sps....Lsh..ssh-hh...sh.t..h.....st.t...............................................................s.....sssssa......psslPss........RsG.hpV......l.hshWphu...D..oss..............................................................uFYsshDVs...........................................................................	0	173	287	412
+137	PF00379	Chitin_bind_4	insect_cuticle; 	Insect cuticle protein	Finn RD	anon	Prosite	Family	Many insect cuticular proteins include a 35-36 amino acid motif known as the R&R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region [1]. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD) [1].	21.50	21.50	21.50	21.50	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.69	0.72	-3.70	157	3539	2009-01-15 18:05:59	2003-04-07 12:59:11	18	25	87	0	2490	3895	1	53.00	32	25.39	CHANGED	YpasYpsssu.tt.....pppup...............tsstslp.GsYoahssD.Gp.hhsVp.Y.sA.Dcs.G.F	..........................................YpasY..ps...pD..s...ps..............pppsp............................sussVp.GsYo..h..hssD.Gp..hpsVp.Y.sA.Dc.s.GF..........	0	942	1256	2169
+138	PF04968	CHORD		CHORD 	Finn RD	anon	Pfam-B_1217 (release 7.0)	Family	CHORD represents a Zn binding domain. Silencing of the  C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of  the wild-type gene in nematode development [1]. 	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.57	0.72	-3.73	47	678	2009-09-11 00:43:51	2003-04-07 12:59:11	7	14	243	3	422	649	3	62.90	45	38.49	CHANGED	hstpCpNtGCsppap.ssc....s.scssChaHPGsPlFH-uhKtWoCCpp+...shDFs-FhpI.GCsp.GpHs	.................h.htCpppGCu..p....pas....s..s..p...............s...pc-sCtYHPG..sP..lFH.........-uh...K..............uWSCCcc+...shDFspFLsI.GCsp.GpH..................	0	135	212	319
+139	PF02017	CIDE-N		CIDE-N domain	Bateman A	anon	[3]	Domain	This domain is found in CAD nuclease Swiss:O76075 , ICAD Swiss:O00273 the inhibitor of CAD nuclease. The two proteins interact through this domain.	21.80	21.80	21.90	22.20	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.51	0.72	-4.21	7	382	2012-10-03 10:59:06	2003-04-07 12:59:11	10	9	81	7	199	371	0	76.00	38	26.28	CHANGED	p.+Ph+lpshcpsh++GVsApSLpELlsKst-hhtlsp..tssoLsLtEDGT.V-sE-aF.sLscsTchhlLttGppWps	....................+Ph+lpstpRsh++GlsA.soLpELhp..K..........sp..........c..t..L.tls................tsssL.VL..-.EDGTtV-sE-YFpsLssNTphhlLppGppWp...................	1	36	51	107
+140	PF02487	CLN3		CLN3 protein	Mian N, Bateman A	anon	Pfam-B_1060 (release 5.4)	Family	This is a family of proteins from the CLN3 gene. A missense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein (Swiss:Q13286) has been implicated in Juvenile neuronal ceroid  lipofuscinosis (Batten disease) [1].	24.50	24.50	25.00	25.10	23.60	24.40	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.29	0.70	-5.69	2	477	2012-10-03 03:33:39	2003-04-07 12:59:11	12	13	234	0	293	463	9	272.00	30	81.25	CHANGED	.hhhFWLhGLhNNh.YVVhLSAAhDIlu...............P..shs.......pSl....VLLADIhPoLhIKLhuPhhlchl.YS.Rlhs.hhhushuhhLVuF.+slhssLhGlshASISSGhGEVTFLpLTtaY.phslshWSSGTGGAGlhGuhSYhhLTp.htlssphTLLsh.hlP..hhh.aaFhLpSs-sp.shtp.pt.spAcps.lss..ss.o+ss......Sop.pl.pphphh+tLla.YhVPLshVYhhEYhINQulh.hLhF..s............hpatp.YhhYthLYQhGVFlSRS.hHhhRhR.halLAhLQslNLshhllpsWF.hh.S.ahVhllIhYEGhLGGAuYVNTFhNIh.ppsspcpEFAMuAssIuDohGl.LuuLLuLsLcshLC+hp	.....................................................s.......................................................................................................................lllsslhPshhh+h..h..P.h.hh...hl.a.......Rhhh.hh.hthh.uhh.......hl....uh..........s..............t.......s......h................h..t......l..hGlhhsShuuuhGEhshLt.h.st.ha.........................s...l.shauuGTGhuGlhGuh.a.h.hhpt...hths.t...shh......h.s....h.a......hh.....h.....l..............................................................................................................................................................................................................................................h.......t.....p.h......h....h..........h....hh..hh.hPLh.hVYh...hE...Yhlspul..h..lha................p.h..t.t...Y.hh.thhY....Q.......h.....G....VFhSRS....o.........h...............h.........h..........p........h...........p......hhh....shhQh...h.hhh...h.h..........hts...........h...h..................h.......h.........p....................h.......hlh.hl....hhh.GhhGGhsYVNs.a.............h............h........p.........................................t..............p..phshshhs.s.shuh..hushh..........................................................	0	118	172	253
+141	PF02861	Clp_N		Clp amino terminal domain	Bateman A	anon	Pfam-B_102 (release 6.0)	Family	This short domain is found in one or two copies at the amino terminus of ClpA and ClpB proteins from bacteria and eukaryotes. The function of these domains is uncertain but they may form a protein binding site [1].	20.70	7.40	20.70	7.40	20.60	7.30	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.23	0.72	-4.03	167	16656	2009-09-14 13:11:56	2003-04-07 12:59:11	15	55	4576	80	4358	12959	3258	51.20	24	11.11	CHANGED	A.pphApphscpalssEHLLluLlppspuhstplLpphGlshpplcptlpphhs	...................Atp.Apphsc.palssEHlLluL....l.......c....p....s..p.......u........s..s......s....p..l....L..p....p.h...G.l.s..h..p.pl.cpt.lpphh.................................	0	1453	2953	3792
+142	PF02353	CMAS		Mycolic acid cyclopropane synthetase	Bashton M, Bateman A	anon	Pfam-B_862 (release 5.2)	Family	This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyse the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.72	0.70	-5.32	12	4148	2012-10-10 17:06:42	2003-04-07 12:59:11	15	22	2427	44	1236	14323	7479	263.10	35	68.06	CHANGED	pchcpphcslptHYDlSsDFFpLaLDPohTYSCAYFcc.......sDhTL-EAQhsKlDlhLcKLpLpPG.pLLDlGCGWGuhhh+AspcYDVpVlGlTLScpQhphspptlsphshtcphclhLtsac-hs-....hD+lVSlGhFEHh.......Gh-pYssaFptsapll.ssGhhLLHoIsshc.cphs.tth..........cFIsp.IFPGGpLPolptl.p.pspcsGFplhchpsLp.HYAcTLchWs-sLptph-cAhsl.huEchhchahhYLsuCAttFRhGhlsltQh	......................................................................................p...ppshpsl.ptH.Y...D...l....u....N..-...a..ap.h.a..L..D.s.s....M....p..Y.S......C..Aa...a....c.s......................................s..c...p....o....L.....-...p...A....Q............s.....K..l....c...h.......l....h......c...K.....L.....p.....L.........c.......P......G.........t......c.....l.....LDI..G..C..G...W...G...u...h.....s......h...h...A.....A.....c.....c.........Y......G...s....p...V...s..G.......l.......T......l......S.p......-......Q....h.......p.........h....u............p.......p.....+..........h....c............p......h.........s......h......t..........c.........p..........l...........p.......l.......h.....L......p.....D...........Y......R........-......l.....s..s.................pa..D..+.......I....V......S.....l....t...M..h...E...H..V.......................G...h.....c.....p.....a....s...s....a....F....p...p...l....p...c...h.L.c.s.......s...G..h..h..........l........l......H.....s....I....s....t..t....c......p....t....h...t...s............................................sa.....I..p...+...Y.....I......F.....P......G......G.....h.....L...P.....o.....l.....p.....p...l...h.....p...........h......p...c...s.......s.....h........p.....l......p...c.h....c..s......h....t....h....H...Y......s......c..T.L.pt..W.......tcp..ap............s.......p...h...............s..................c............l....h...................t............h........h..............s...........-........c........a........h.......R........h....W.ph....Y....LsuCssuFct..t.tlplhQh....................................................................................................................................................	0	353	757	1043
+144	PF00780	CNH		CNH domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.79	0.70	-4.98	62	1933	2012-10-05 17:30:42	2003-04-07 12:59:11	17	73	285	0	1105	1799	2	265.10	21	23.92	CHANGED	sssh...stspplllG.T-pGlalhsh.............t..ht.sphhph.t......lpQltVlpphslLlhl........u......s....cpLhsasLssLpstp.........t.....................plsts+ssphhs...........sshstsphLssuh+p.....slhlhchhp.shppht......................chhp-..hths................s.shslphh.......csplClGs...........ppsFcllsls.p......sts..tslh.p.sstt..........h....tthpslshhpls.......p.s...chLLCasphuhaVst...pGt......psc....shtlpWss...tPpuhsh.htsalluFps.sh.lElRslpss.....cl...hpplssppl+hlssss	............................................................................................................................................h......t...lllG.s-.p.G...l...hhhph........................................t.sph..p.hhs................hpQltl....l..pt..s........l.Llsl................u...................................s......pplhha.LstLpsp..t..............................................................................................pl.schc.G.sthhp.............hsth....pt....h....p........h...L..s..sAl+p.............plhlhp.h..t.....t...s..htph..............................................................p.hp-...h.p.hs................s.shslshh............p.p...lslGh.....................................sss.Fp..hl.sls..p...............uss.....slh.....sp.p..........................................t..h.....p..s.h...t.lh.pls...............................p..s........chL.l....s....a.....s.....p....huhaVst.............pGc....................hsc......p..lpW.s.t.........h.Pp.u...h..............s..h...t.........t......s.......lhu.a...tp....pu...l-l+.s...lpss......pl........hppht.h.pphphh....s...............................................................................	1	320	476	785
+145	PF00027	cNMP_binding		Cyclic nucleotide-binding domain	Sonnhammer ELL, Finn RD	anon	Prosite	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.62	0.72	-4.17	342	26013	2009-01-15 18:05:59	2003-04-07 12:59:11	24	502	4562	267	10760	22035	3366	90.20	18	23.38	CHANGED	hpphptGphlhppG-....sstlallhpGplclhptspssp............................hthhtsGshhGchshhtsp.........tsssshA.....hsssplhtlsppphpplhpppsp	.......................................................h...httGph.l.h..p...p.......G.-...........ss..p...h.......ah..l.h.p..G.......p......l..c......l...h.t.t...s...p..s...s.pt......................................................................................................hht.hh.t..s....G....s.....h..h..G...c......h....u..l..hpsp..........................psss.spA.............hs.s..s.p.l.h.tl.s.t.p...phpp..lhtp...t.........................................................	0	4474	6939	9042
+146	PF02629	CoA_binding	DUF184; 	CoA binding domain	Mian N, Bateman A, Griffiths-Jones SR	anon	COG1832	Domain	This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.99	0.72	-3.47	70	6798	2012-10-10 17:06:42	2003-04-07 12:59:11	14	37	4404	64	1756	6726	3805	96.70	32	28.56	CHANGED	scpsclhlhGhosp..phs.aphppthphshp.hlhulsPp.csG.pplt.........GlPlatslc-hhcch......t..sssulIhV....PushAtcsl.Etlc.Asl+slVslo.G	.......................................cpo+Vll.G..ho...G....p..pth..a...+.s....p...p...t....h....s......h.......G.......sp....hlh..G...l.sPt...+....s....G....p.p..ht..........................................GlP.V...a...s..s..l.c...-..shpph....s......ss.sulIhV......P...s...sh...s...t...c...ulhE.ul.....-..AslchllslTtG..............................................	0	610	1119	1487
+147	PF01144	CoA_trans		Coenzyme A transferase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.19	0.70	-5.16	43	6881	2012-10-04 00:26:15	2003-04-07 12:59:11	18	14	2405	102	2146	5554	1112	208.60	24	73.96	CHANGED	hpphspAlu.plcDGthlhlG....hG.hP.sLlsslhcps.....hsshshlpsss..Gh....hGluslhhstplccsl....ssh.hsp.......shhhspphhsuph.phchhsQGshh-thhhGGstls..u.lsssslG.shhttt......................phhshs..........Gtthllptuhpsslshl+ttptDthuplhacsostphs.shhs...........sthlT.hpV.cls...hsph.s.phhhPGlhl-pllts	..................................................................................h..phtptlu.tl....pDGthl.s.....l...G........hG..h.........P......sLl....s.s.l.h..pp.......................psh.shl.psps.....Gh...............hG.l.G...h.......h...p.p..t..p....l..cphl..........ssh..ssp.............shhhspt.hhs...u...p...h....ph.t.hspGs...hs-hhh.hGuht.....ls..G.lss.h.u...l...s...s.htst................................................................................pl.h..s..hs.................G..t..h...h.L.h..t.t....u..h.p.h.s.l.sl......h..c.t.pp.s....Dt.....pu.....plhh....c....psh..h..s......sshs.......................shlT.lpV.c..ls........h.s...p...h.......s....p...hhPGlhV-plh..t..................................................	0	620	1257	1756
+148	PF02514	CobN-Mg_chel	cobN-Mg_chel; 	CobN/Magnesium Chelatase	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_647 (release 5.4)	Family	This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid [1]. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis [2].	18.40	18.40	18.50	18.50	18.20	18.30	hmmbuild  -o /dev/null --hand HMM SEED	1098	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.88	0.70	-13.70	0.70	-7.17	129	1875	2009-01-15 18:05:59	2003-04-07 12:59:11	11	21	1069	0	690	1853	1652	877.50	30	85.15	CHANGED	lhpYhttGG......tcNhpshlphLspph..........thts..........tsPhthPp.h.GlY+.st.........thhtt.t.h.t.....................t..tssVGllh.aRuhhhuushshhDul..lcsLEpcG.hsslslassu.........tstst..ltphhht...........tlD.sllshsuFulsssss.t............uhphL.ppLsVPllpslhh..hpohcpWpsuspGLs..sh-luhpVslPElDGtltsh.slut+pt........s...t..h.....tthtPhs-Rlchlss+stpalpL+cpsss-K+lAlllaNaP.sp..pupl.GsAs...hLDs..sSlhplLptLpppGYsl..........s...lPps.scpLhctlh.tthsss..h.st.t.h.p......hh.hshpcYhpaasp...Ls.thppclpppWGssPG..........t....hlh....t...............hhlsGlphG.NlhlulQPsRG.....hpt..Ds.h...phhHssslsPsHpYlAaYhWLcct.....apADAllHhGsHGoLEaLPGKplGLSssC.aP-hllGslPplYsYhlNsPuEGs...AKRRutAsllsHLoPPlspAuL..YssLtcLcphlccYppst....t.sst..ctptl...tppIhphsp.phsLsp.-...........................................................................................................................shtphlsp..lcs...aLp-lcps.IspGLHlhG..psPp.......s-ph...sphlhshhphs............sh.t..h.....................................thtttphhphlpthstth......t..................................................................................................................................................................................................................................................................................................................................................................................h..hh.thh.tl.....ssspElsuLLpALsGcalsPGPuGsPsRs..-lLPTGRNhauhDPptlPopsAaphGpchA-pLLc.cahp-p..Gc..aPcslulsLWGossh+otG-slAQhLtLlGV+P.....laD.ssGRVsslElIPLs-L.........GRPRIDVslplSGlFRDhFPphlpLlDcAlphlAs..................h.D.Ess-.Nhl+ppsht..............t.t.s.....p.uthRlFussPGs..YGu.G.lsthl-uu.sWcscs-Lu-sYlstpuaAYG.......t.s...s........tu...........p...pspc................shcptLpsl-sshpsp-opE...hslhDsDcYapahGGlstAlcpls..Gp.pPshYhuDps...pssps+l+oLp-pls+.hRoRlLNP+WlcGMhcHGYcGAtElutpl-thaGasATs.stVscahacplscsalhDcp...hpcalpp.tNPhAhpshspRLLEAtpRGhWp.sssphlc	..................................................................................h...ah..Gu.......tNhtthh..hh.t.h......................................s..hs..t......u........l..ht..........................................................................................................tts.hlullh..+shh.ss.s.hshhp...slhptl......ct.tG.hps.lslas.u...........................t.............l.ph.h.t.....................ss.hlls.hh.t....hs.hss.......................t.thh...tth..s.hP.l.hpsl.......htshttW.t...t...s.....pGls.......sh...phshpls.l.PEhDGtl.sh.shuhpp................t......h.......th.s..cRhthlsthshpahpLpphsstp++lAllhhsaP..s.......t.....psplusu..s....hLDs..t..S...hhtlLpthp..ttGYpl.............t.......h..........P...............t.................s....sptLhp.lh...........s.....s...............................hsht...pY.th..htt...l....thtpth....tt.WG.s.s...............................t......hh..........t..tt.......................hhlsuhphG...NlhlhlQPstG........ht.t....ss...t.hHs...shsP.HtYhAhYhWlpp..............................atu-AllHhGpHGsLEalPGKthulSt.t.C.aP-hhlGslP.lY.ahsssPuEus...AKRRuhA..sllsalsPPhtpAth..Yt.t.ltcL.cpllsca.ph.........sst......ch..l..............tppIhph..ht..thtlpp-h............th...............................................................................................................................................t.thltc..lcthLt-lcp.t........l.tGLHlhGps.s.p.......s.pt.h...hthlhshhp..................sl..............................................................................................................................t....ht.ht......t........................................................................................................................................................................................................................................................................................................................................................................................................................h.....hhtt.h..h.tl...tsstEhtslhpuLpGtal.suPuGsPhRs..plLPTGRNh.auhDsptlPo.hAhphGhthAppllp.pahtc........p..Gp.aPcslulslWGossh+otGpsl.AphLhLhGlcP.....hhs..st............tRl.......s.sh.cl.ls.....tpL......................sRP......R.l..DVslp.lSGhFRDhFs.p.hthlDpAlphsAt...........................................h...-.Es.c.N.ltt+s.t...................................t.s.................ptuthRlFustsGs...Y.Gu.G.lpthl-s......t...tW...........ps...............ct-....Luc.sahshtuaAYu..............t..t................u...........t......ttt.........................hhpttLpphphshps.-spE...hslhsss...caapa.GGhhtsspthp...........G......p...t.......st....h......a..hsDp.s...p...pp..sphcslp-phth.hRs+hlNPcWhpuhhpHGYc.Guh-h.s.t.pls.hhGa...........sAT...s.thl.....s...sahap.tltpsalhD.t...hpphhtp...N.PhAhpphs...t+hlEA.pR......uhWp.ss.p...t............................................................................	1	220	463	581
+149	PF02492	cobW		CobW/HypB/UreG, nucleotide-binding domain	Bateman A, Mian N, Bashton M	anon	Pfam-B_428 (release 4.0) & Pfam-B_1247 (release 5.4)	Domain	This domain is found in HypB, a hydrogenase expression / formation protein, and  UreG a urease accessory protein.  Both these proteins contain a P-loop nucleotide binding motif [2,3]. HypB has GTPase activity  and is a guanine nucleotide binding protein [3]. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression [1]. UreG is required for functional incorporation of the urease nickel metallocenter.[4] GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins [1]. This family of domains also contains P47K (Swiss:P31521), a Pseudomonas  chlororaphis protein needed for nitrile hydratase expression, and the  cobW gene product (Swiss:P29937), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans [5].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.41	0.71	-4.83	62	9942	2012-10-05 12:31:07	2003-04-07 12:59:11	14	44	3597	7	2693	11049	3134	177.40	27	56.79	CHANGED	sshslsG.lGuGKTTLLpcll.....pp...h+lAVIhN-hs..sshDuphl..........pps..ss...............llplssGshCpo.lptDh.hslpsltcht.......................................phDhllIEssG.lssPssh......................shthDshls....llDs.........................scscchspph.ptlthADllllNKsDLssts.tshcthtpphcplssptpllh	......................................................................................................................hhllsGaL.......G...uGKT....TL...LpclL........................p.pps....h.+lAV...I..h....N.....-.......hu.....t......s.....s...l.D.....u.....p.....l....l.......................................................tps......ss.....................lhp.l.s...s....G......C...h.....C.C....o.....hp.......t....D....h....h.s...l.p.s....l....hcht...............................................................................................................................................................ph.D.....h.l.l.....I....Eso.G....lsp.P.s.sl.......h.....................................h.........h..t..l......c...s......h..l.s.........l.lDs....h...........................................................................................sp.t..p..s...h..s...p...h.h...h..p..Q..l...t..h..A...D.........l.........l.........llNKs.D...L..ss.....t.......p........p..thp...p.th.p.p.lsspt.h..t.....................................................................................................................	0	789	1689	2240
+150	PF00135	COesterase		Carboxylesterase family	Sonnhammer ELL	anon	Prosite	Domain	\N	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	535	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.71	0.70	-5.80	123	8736	2012-10-03 11:45:05	2003-04-07 12:59:11	23	92	1650	371	4719	13851	2441	405.50	22	85.47	CHANGED	hhhhhhhhhhhhhhhsstss.........................ltst......GplcGh.hts.tt.....t..h.sFhGIPaAcPPlGpLRFctPpP.....sps....W.pslhcuophsstChQ.sphh...................hpsshs...................SED.CLYLNlasPphspps............................................hPVhVaIaGGuFhh..........Gsu........s.hsusthhhpcsVllVohsYRLGshGFLohsspphs......................GNhGLhDQhhALcWVppNIssFGGDPsplTlFGcSAGuuSVshhhlS..........ts...cuLF++AIh.SGsshssas.hpsss..hphspplApthGCsssssp..................plhcCL+.ptsspcllsspt..hhhthhshhs...............hhP.............sl-us..................hlscpP......tphhppu.hp.plshll.GssppEGhhhhshhhtt.tt.........t.p...................................hhphhtthhh.hspht........tpplhptYhss.pt..st.pph.pthtplhuDhhahts.hhthhtphppsssss.YhYpFsapss........hthh.thtsssHus-ltalFstshhtt.th.........................ppcctt...cphhphassFApsGsP...............s...t.stWsshspp.....t.hthhhtstpthhtpp.......hpaa	..............................................................................................h........................................................h..h.........u.h...G.................................................h...........ahGlPa.A.tsP..h.....t....................................R.a.......t......................P.....................................h.....p...t.......h......p....s.......p.....p..................s........s..........s.Q.................................................................................................sE...D...C...L...h..L........N..l..a..s.P..t......t..t..tt...........................................................hP...V.hla.........l.....a................G.G..u..a....................................Gsu........................h..t.....s.....t...........h.....h.............t......t......s......l......l.....l......Vohs....YR.....l......G........h.......h.............G....F.....h...s....h......s.....t.t.............................uN..h.....G.......l...h........D....Q......h....h.....A.L....p....W..l........p........c.......N........I..t...........t..........F.........G............G...........D....P............p...p..l..T................l....h....G.p...S.A.......Gu........h...u..l..t..h.h...hhs....................s.s...............ps........L...F..........p...p..u........I..h......S...............G..........s.........h...h....................................h.....h..t...................thh..th...s.....p.....h..s.ht....tt...................................................hp.p..L....p...t.h.s......p..p...l..ht...........................................................P...........................................h.l.-.s......................................................hls...p.......................th..h......t.......t.......t.............h.............p...........h.......s.......h..hh...G......s.p....p..Es................h..h.h..........................................................................................................h..........h....................................t.h..h......a........t.................................................................................................................t.h......t...hhs....-..h......h.h.....h....s.........................h............................................h................t...........t.............................t....t..............................ahY.ath.s.................................................................t.s..H.s..-..h....hh...a..t.............................................................t..h.......t.h.thhhs.Fs..t..t..s....ps...........................................a....................................................................................................................................................................................................................................................................................	2	1694	2505	3925
+151	PF01484	Col_cuticle_N		Nematode cuticle collagen N-terminal domain	Bateman A, Bashton M	anon	Pfam-B_200 (release 4.0)	Family	The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see Pfam:PF01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins [2].	20.80	20.80	20.90	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.38	0.72	-4.28	113	1198	2009-01-15 18:05:59	2003-04-07 12:59:11	12	22	21	0	1054	927	0	51.90	23	16.32	CHANGED	hss..usshSslullus.llslshlasplpshpsplps-hpth+spuc-hWs-h	.....h..shhusshSslAllss.llslPhlashlpplpsplps-lshh+sp.......u...cshWpch...........	0	359	519	1054
+152	PF01391	Collagen		Collagen triple helix repeat (20 copies)	Bateman A, Eddy SR	anon	Swissprot	Repeat	Members of this family belong to the collagen superfamily [1]. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix.  The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline.  Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-11.88	0.72	-11.88	0.72	-4.43	41	44425	2009-09-12 04:47:45	2003-04-07 12:59:11	13	899	1492	46	19240	35044	5977	63.30	39	36.42	CHANGED	GssG.sGssGssGssGssGssGssGssGssGssG.sGsPGssG.sGssG.sGssGssGts	.............................................................................................G........G........s......G................s.....G.....................G...............t......G...........s.....G..............t........G............s......G...............t......G....s....t......G................t.......G............s......G........s.....t...G.........s.....G..........s....G.................G........G..G..h............................................................................................	0	3964	5810	11551
+153	PF03772	Competence		Competence protein	Bateman A	anon	COG0658	Family	Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA [1,4]. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.	20.20	20.20	20.30	20.60	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.75	0.70	-5.34	123	4251	2009-01-15 18:05:59	2003-04-07 12:59:11	11	14	4131	0	907	3604	477	262.70	21	39.09	CHANGED	LlhG-+s.tlspphhptappsGlsHLlAISGhHlullss....hhhhlhphh................hssptht..hhhulhhhhh...Y.shlsGhss.sshRAhlMhslhhhuhhh...t+c....hsshssLshuhhllL.lhsPhslhssGF.LSFhAlhullhhh........thhpphhthhthhhh............................sshss...plssh..PlhhhhFtplSh.hullsNLlsl.Pl.huhll....lPhhlhuhlhhhh..............shuthhhh....hh..th......lphlhthh.phhup........hsh.....lhh..stsshhhhhhhhhhlhhhhhhhthh	..............................................lhhGc.p.p.tls.p.c.......h.pphhppsGlsHLhAlSGhHluhhhs.......hhhhl.httl...................................................h.s.ptht........hhhshhhhhhY.s.h.L.sGhss...uslRAhlhhs.lhh.h.h.h.hh........t.p.p..............hs.shp.s...lshshh.h.ll.lhsPhhlhshGFhLShhAshsllhhh............................thh...t.h.hth..h......hh..h..............................................................................hs.hsh.plshh..PlhhhhFtphsh....hu.......hls...Nllhl.Pl..hshlh...lPh...hlhshlh.hhh..........................lsthhhh.................................hh......shh.......hthlhh.h...l....phhsp..............h.........hhh...s.t..sh.hhh.lh.h.hhhhhhh.hh.....h.........................................................................	0	309	604	770
+154	PF05071	NDUFA12	Complex1_17_2kD; 	NADH ubiquinone oxidoreductase subunit NDUFA12	Bateman A	anon	COG3761	Family	This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues.  The family also contains a second related eukaryotic protein of unknown function, e.g. Swiss:Q9BV02.	21.30	21.30	22.00	21.50	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-11.06	0.72	-3.57	88	843	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	595	0	467	747	993	102.70	29	67.27	CHANGED	GphVGcDchGNpYYcst...........stc+RWVlYs.uhs.......E..ASpVsP-WHGWLHaphDpsPo...pp.shst+sWpc..sHp.NhT.GTstA..YtPtG.....uh.....t......psh.ptD.YcAWsP	..................phVGpDchGNpYYEst...............pthhtp+RWV..Y..s.stt............-........uopl..P......P..pW...........HuWL+at..t-pP.Po........pp...t...h...t.......c...p.a.pp....+.p..Nho...so...tt..Yhs.s......................................................................................................................	0	150	256	364
+155	PF00329	Complex1_30kDa	complex1_30Kd; 	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	Finn RD	anon	Prosite	Family	\N	21.10	21.10	21.30	21.70	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.32	0.72	-3.78	131	5889	2009-01-15 18:05:59	2003-04-07 12:59:11	14	20	4153	16	1220	4082	2058	105.60	34	33.03	CHANGED	plhphL+pp...thshLsslsusDhhptt........chplsYp.lhsh.....tpspp........ltl+stl.st..cssplsSlsslasuAsahEREsaDhaGlpFpG.HPc......h+.Rllhs.-s...a.s.......aPLRK	.........................................................hLh........tashLh.slsuhDhtsts..................caslhYp...Lh.s.h......p.p.s.pc....................lpl.K.l.....hs..st...........ps............s......p.......lP...Sls..la..uAsWhEREsaDMaGIhasG.HP.c........L+.RIl...h.s..ps...W.G.......aPLRK..........................	0	403	782	1023
+156	PF02950	Conotoxin		Conotoxin	Bateman A	anon	Pfam-B_529 (release 6.4)	Domain	Conotoxins are small snail toxins that block ion channels.	25.10	25.10	25.20	25.10	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.34	0.72	-3.18	112	926	2012-10-01 22:06:18	2003-04-07 12:59:11	12	1	54	27	2	953	0	70.10	26	96.65	CHANGED	hKLshlhllslLLlo.......ss..stsspt.sp.......p.tpthpphpssp..pphh...ptp..h.....................hsppCCsh.....hC........hCh	........................KLss.lLhlslLLhs.....hsshthsu-pssc....................p.scp.t.p.chpssc....p.p.th...hh..........................htppCCsh......hCt.......h.sC......................	0	0	0	1
+157	PF05019	Coq4		Coenzyme Q (ubiquinone) biosynthesis protein Coq4	Wood V	anon	Pfam-B_14948 (release 7.6)	Family	Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway [1].  The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).	20.50	20.50	20.50	20.80	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.36	0.70	-5.44	27	475	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	363	8	319	505	118	198.00	31	79.73	CHANGED	YsuHlPL....sshp+hhLssGSulsulhcPcR.uDhIAsLGEsTuh.hhLppL+cpMhsDspGRpIL+-+PRIoopoLshstLpphPcsThGtsYspaLccpsVoPDoRssV+alDD.EhAYVhpRYREsHDFhHslhuhPhsh.GElAlKhhEhhNhGLPMshLuulhushRL+spp+pphhphYlPWAl+sGhpu+.......sLlNVYWEchhEpDls-LRcELGIp.sPc	............................................................................tph.hhhhuuhhu.hh.pP.c.tp.....l.shhuE.so.uh...hl..phh.ppMhpsspGpplLp-+.Pclssps...l...........s..hstL......ps.L..Pps...olG........tsYhpaLcp..............ps.lo........P...D........s.........R.s..s......l........c.......a.l....-.....-..........-......h.....A..Ylh..pRaR-sHD.haHslh.G.hs.h.s.h.....GElulKhhE...hh........p...h.......t..l......P.......h...sh...L....s.....ul...h.u...s.h.......c.........L............p.....t...p..t.p...........t........h........hp...........h.h..l......P...W....A..hcs....G....hp.u.c..............lhslhaEc.hh-pslpclRpcLsIp............................................................................................	1	90	172	272
+158	PF03471	CorC_HlyC		Transporter associated domain	Bateman A	anon	Bateman A	Domain	This small domain is found in a family of proteins with the Pfam:PF01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux.  The function of this domain is uncertain but might be involved in modulating transport of ion substrates.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.46	0.72	-4.20	174	11377	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	4360	35	2334	7354	2259	80.60	23	18.84	CHANGED	pphssssallsGphslc-lpchhsl.p....lsp.c..c.....hc.TluGhlhpplsclPp..G-......ph........p...s...............hp.hpVhchcsp+..Ipplclphhp	....................................p..hscssallcGpss.lc-...l.sch.h....sl..c.........ls-..-............-..............hc..TluGhl...hp..tl...s..c.l.Pp...hG-.......pl................p....s..................................hp..hplh....ch.-.sp+....lpplplph..t................................	0	682	1425	1903
+159	PF02389	Cornifin		Cornifin (SPRR) family	Bateman A	anon	Pfam-B_1215 (release 5.2)	Family	SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid [1]. 	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.63	0.71	-12.31	0.71	-4.54	5	373	2009-09-13 06:27:35	2003-04-07 12:59:11	10	30	87	0	232	424	33	118.10	16	44.10	CHANGED	cQHQVKQPCQPPPQEsFVPp.TKEPCHocVPpPGNT........................KlP-sGsThV.EsshT........................KVPEPspTKVPEPCpoKVPEPspTKVPEPCsTKVPEPsYPKVPEPupsKVPE.G..................................PsHsKsPEPGasKVPEPGhPKVPEPCQo+VPEPCPSTVTPusAQQKTK	................................................................................................................................................................................................................t........th.tst.....st.hs.t....t.....th.p....st..ts..ths..t.t.....th.t..st........th.s..t....t....th.....t..................................................................................................................t.................................................................	0	106	118	167
+160	PF02628	COX15-CtaA		Cytochrome oxidase assembly protein	Mian N, Bateman A	anon	COG1612	Family	This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus  subtilis [1]. COX15 is required for cytochrome c oxidase assembly in yeast (Swiss:P40086).	21.50	21.50	21.50	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.24	0.70	-5.55	146	2337	2012-10-03 10:28:09	2003-04-07 12:59:11	10	13	2048	0	837	1935	3330	287.80	24	85.08	CHANGED	thhhhhshhhshsllllGuhTRLTsSGLuCs-.WPsChGt..hsPhsptp.............................hth....ahEahHRhhuthlGllhlshhlhsh.............h.h.h...tthh.hh.shhlhhLlshQuhlGhhhVp.s....l...............p.hh.lssHLhhuhhlhuhlhhhshphhth............................hsh..tthphhshh.sls.llhlplhhGu..hluu.pAuh.ss...................st.h..h..................t.h...........................phhHRhhAhlshhhhlhlhhhhhhtt.........tthpphuhhh..hsllhh.QlslGlsslhh.tlPl.h...lulhHphsAslLlsshl	.........................................t.hhhhhsshhhhslllhGuhs..RlTsSGLuCss.W.PhCt.Gt...hsPhstt.t.................................................................hphhhEasHRhhuthlGl.hhlhhslhsh..............................................tt.tth......tpphh...hh.shhhhsh.lshQ...............uhl..G...hhs..VthsL.....................................................................sshh...lu...h...HLh.hu..hl.h...hus.hh.h.hshtlhp.....................................tp.hh..tth+..h.h..s....hh.hhh..hlhlt.l...h....h.Gu....hV..uu....p...A.uh.sh...............................t..h.h...........................h.....hp..thl..........................................phsH.RhhAhh.shshlhhhhhhshpth..........................tthtthshhh..hhllhl..Qs.hlG..lhslh.........h.....tls...........l...h............lu.hhHthhushLhshh.h...................................................................................................	0	262	541	716
+161	PF02936	COX4		Cytochrome c oxidase subunit IV	Bateman A	anon	PSI-blast P00423	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium member of this family is called COX VI Swiss:P26310. The yeast protein Swiss:P53077 appears to be the yeast COX IV subunit.	23.50	23.50	23.60	24.00	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.77	0.71	-4.45	10	463	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	283	51	246	436	0	129.20	29	76.99	CHANGED	chVuptshupPshsDl.-pWtshsp..pEpssllssLR-+pKssWpsLSh-EKKAlYhISFspphsc.httssGEhKhlhusslhslulohslhslh+hhshPphP+Ths+EWQcussEhhhspchNPlsG.huptYchcsph.p	.......................t.t..u.shhhshp.ch..s...........p.-...ss.hpsL+-+pKssWppLohpEKpAhYhluFspphsc....hpt.sssEhp...plhs.ss..hhhluhohhlhhh..+ha......s.h..s...P.pThsc.E.Wpttp.chhh...s.hphNPlpG..uttashpt.....................................................	0	62	111	185
+162	PF03626	COX4_pro		Prokaryotic Cytochrome C oxidase subunit IV 	Finn RD	anon	Pfam-B_3217 (release 7.0)	Family	Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyses the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.	25.10	25.10	25.20	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.75	0.72	-3.89	250	2280	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1772	0	517	1230	725	81.10	30	74.43	CHANGED	ahhsallhllLTs..lshhls...........................hts.......hh.s.hshshsll..hh.lAhlpshlhlhaFMHlpt.spp.........hhphllhshllhsslhlhh	........hhGFlLullLTl.lsFhhs...........................hts.......sh...o..ssh..lshl...ls.hAllQshlpLlhFhHhsp.psctt.p....hhthlFsll..l..lsh.lllG.olWlh................	0	131	290	402
+163	PF02937	COX6C		Cytochrome c oxidase subunit VIc	Bateman A	anon	PSI-blast P04038	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.	21.40	21.40	21.40	22.60	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.37	0.72	-4.09	8	161	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	101	51	89	163	0	69.70	43	80.44	CHANGED	ushLsKPQMRGLLu+RL+hHlVsAFlluLGVsAhaKFusA-PRK+AYADFY+NYDAMK-FEcM+cAGlFQSVK	..........s...lsKPt.MRGLLs.+pl+hclssAhslo.lssusha......KasVs-.PRK+AYADFY+NYDuhK-FEcM..+c..AGlFpSs..............	0	23	28	53
+164	PF02935	COX7C		Cytochrome c oxidase subunit VIIc	Bateman A	anon	PSI-blast P00430	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII Swiss:P04039.	25.00	25.00	25.10	25.00	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.21	0.72	-4.17	14	253	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	202	51	155	269	0	68.00	35	72.16	CHANGED	Mlupp.....sRRssspulRt.+...........atpGPsp.........NlPFpVpN.KahlhshhhsFhusGFusPFlllcaQLhKp	.............................tpt.....sR.p.h.ss..s...s.h..Rt.p.................asEGPtp............NLPF....s..l.....ps..K.ahhh..hhahsahusGF.usPFh.ls.haQhhK...........	0	42	76	124
+165	PF04516	CP2		CP2 transcription factor	Mifsud W	anon	Pfam-B_2156 (release 7.5)	Family	This family represents a conserved region in the CP2 transcription factor family.	25.00	25.00	28.30	28.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.70	0.70	-5.31	29	661	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	171	0	367	552	0	208.40	37	38.82	CHANGED	oh..p.p.h....h.shhs.tspphshst............tpphcFphsLpAPTAhhp+tsE.PlTYLNKGQuYslolh-s..ss.sshpssp...hR.ohlRlsFc--cpppc.tppWphW+.......u+Q+suK.psl-hsDhpp.......shsplp.lEpsua..suhsVhWssst.s...EssIhlphNhLSTDFSppK..GVKGlPlRlphcT.hhss..........tssssctschsaCpVKlF+D+GAERKlpsDht+lpKphtKh+	......................................................tttpt.......................................ttspt.sFpYsLpAspS.t.K.t-tshTYLNp...G..Q.Y...t.l.plh-s..tt..s.t.htthp...........V+.SllhVVFc-c+.p...p.phpphchW+........pp.s....pRllDl.D.h..........Shshl.p.......hp.psu...NulpFhWsssc......cspl.FI..pVp.C.lST-..FospK..G...KGlPh....plQIDTap.sp................................p.sc.lHpA.CQIKVF.p.sKGA-RK.h+s-ccKhpK+psp..t..........................	0	66	102	219
+166	PF00118	Cpn60_TCP1	cpn60_TCP1; 	TCP-1/cpn60 chaperonin family	Sonnhammer ELL, Finn RD	anon	Prosite	Family	This family includes members from the HSP60 chaperone family and  the TCP-1 (T-complex protein) family.	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	485	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.32	0.70	-5.88	94	23232	2009-01-15 18:05:59	2003-04-07 12:59:11	19	54	11481	758	4711	17190	6810	316.10	36	86.46	CHANGED	lu......chlpooLGPpGh......sKhlhp..tstphhlTsDGsoIlcclcl.pcPs....AcllhpsupspscpsGDGTTosllLsspllppu.phl...pt.GlcPpplhcGhchAhptslchL......pph..shpsp..............pplhplupsuhsu+..........phlupllscAl...h.............................hclsp....ltlhphpsuph..pcoplh..cGlh.l..c+shhss.......ph.........pph...css.plllhstslph..ps.........t..hts.tth.th.t.p.t.lhphlcplhcts.hsl.................l......lspcsl.....ss.uhphLspsslhulpcl............ccpplccluhhoGup.hlsp..............tslp.s.s.......LGpsppl....plsp..cphsh.lp................................................s...................hsspssolllpGsopthlcEhccslcDAlsss+sslc..tst..llsGGGss.hpluptL.........chsps............hssc.........pph....ulchhupALcths+tLApNuGh.ss..........hpllsp.lps..............tpsp..............thGlshtssp......hh.D.hhptG......llDshpVpppslptAspsAs.hlLplDplltstp	..........................................................................................................................................................................................................................................................................................................................................................................To...........AT..VL......A..p..u.l.lp....E.G.h+.sV....................sA...Gh.......NPh.....s..l.....+.R..G..I-.+.A.l......tssl..cpL....................cph.u.h...spsp................................ctIA..pV.usl.SAssc......................................p.p.lG..p..l...IA-AM..................................................................cKVGp........-GVITl.E..-.ups..................-...p..Lph........sEG.Mp.F......D+.GYlSsYh.............................pph................t.htl.........-sP.aILlh...-.c........K.lSsh..pp....................................................................................l..l..sh.L.-.tlh....p.tu..ps.L.............................l.........Il.u.-.......c.l........-s-AL.s.sL.....l.h.N.....p.h.p..uhhp...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1615	2762	3850
+167	PF02787	CPSase_L_D3		Carbamoyl-phosphate synthetase large chain, oligomerisation domain	Griffiths-Jones SR	anon	ref [1]	Domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  	25.30	25.30	25.30	25.80	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.40	0.71	-4.35	95	8742	2009-01-15 18:05:59	2003-04-07 12:59:11	14	76	7559	40	1436	7541	2587	120.70	43	14.93	CHANGED	lhp.p...LppPsspRlahltcAh.+pGhol-claclT.pID.aFLpplcpllphE.cplpp.....hth.sp.......hLpcsKphGFSDppIA....pl.......h..st........scpplRph.RpchslhPsaKhVDTCAuEFtu.pTPYaYSTY	......................................pcLpcPsDcRhFhlAs.......Al......+t....G..a..o........l-cla...-LT.KIDhW.FLpKhcpIlchp...pp......Lcph...................pslsh-...............hLppAKphGFSD+pIA......th.....................................h......ps...........................oEhs.VRch.R.c..c.h..sI.pP...hhKplDTsAAEasu...sTsYhY.TY................................	0	471	910	1212
+168	PF04969	CS		CS domain	Finn RD, Fenech M, Eberhardt R	anon	Pfam-B_1217 (release 7.0)	Domain	The CS and CHORD (Pfam:PF04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD [1]. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies [2]. Two CS domains are found at the C-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19) (Swiss:O94966), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2 [3].	21.30	10.00	21.30	10.10	21.20	9.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.72	0.72	-3.43	100	2605	2012-10-02 21:54:05	2003-04-07 12:59:11	11	115	372	25	1627	2732	72	77.20	20	23.00	CHANGED	spasWtQo.spVtlsl.l.sss....tcslplphpp.pp...lplt.............lp.st...p.hhhpsc.LhspIss-cSpaplpss........plplpLpK	...........................................phpWtQ...ots.p.......V.h.....lpl...l.sst..............tc.s..l......p.....V...phpp...p.p.......lplp..................................................hp.ttt.......pthhh....p..h......c.....L..h..pt.Ip..s.....-..pS...p..a...plpss.........plp.lpLpK.......................................................	0	581	857	1254
+169	PF00988	CPSase_sm_chain		Carbamoyl-phosphate synthase small chain, CPSase domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_345 (release 3.0)	Domain	The carbamoyl-phosphate synthase domain is in the amino terminus of  protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines [1]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00289. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.	21.10	21.10	22.80	22.30	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.42	0.71	-4.64	134	6372	2009-01-15 18:05:59	2003-04-07 12:59:11	17	41	5635	40	1365	5095	2458	123.10	45	25.61	CHANGED	hpAhLlLEDGolapGp.uhGu...p..u..pshGElVFNTuMTGYQEllTDPSYsGQIlshTaPhIGNhGlNtpD...........hE..S......p.....pstspGlll+-hspt..sSsa+up.poLspaLpppslsGIsGlDTRuLs++lRp.pGshpuhIs	...................................thLhLtDG.s.hapG..u.hG.u..............p......t.............t.sh..GEl............VFsTuMTG.YQEhlTDP...SYp..sQIlshTY..Ph...IGNhGl.ss-.D..........................................hE..S............p..........plpssGllVp-h.s.pp....sSNaR.sp......poLscaLcpcslsGIu.GIDTRtLT+hl.R-.p.G.shpGtI.h..................................................................................................	0	437	856	1143
+170	PF03178	CPSF_A		CPSF A subunit region	Mifsud W	anon	Pfam-B_1224 (release 6.5)	Family	This family includes a region that lies towards the C-terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs [1]. The function of the aligned region is unknown but may be involved in RNA/DNA binding.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.87	0.70	-5.34	80	1132	2012-10-05 17:30:42	2003-04-07 12:59:11	10	23	315	30	802	1130	24	296.80	22	26.18	CHANGED	puslpllss........hp.........sl......s..shpL..p.p.sEtshulppsphp.spt....................t.cp....hllVGTuhshspc..sp............Gplh.lacltp...................cLchltcpcl.cGs...ssAlsth..pG+.llsuhG.pplhlaclsccp.....Llthu.hptsh...hlsslps.......h.......ss....hllluDhh.cSlthl...tapp.........-sp.hhhhucDhp..sh.lsssphL.Dt.c.ollsuDptsNlallch...s.cssps.ssp...........................+L.ppupFalGchsssh..hsll.....t.p.........................llauohpGolG..hllP.lsccshchhppLppplpsph..............slsGhs.pta.....Ruhh................s+sllDG-Llcp.......ahp	..............................................................................................................................................l.lhs..p...hp......hl...p..thph...t...t...tEhsh.......shh.s.p...http..........................................pthhhVGTuhsh..s..p.tsp........................Gtlh.laph.p..............................................................cL.phl..tcp.ph....c.ss............shulsth........pG....+.llsul....u....pp......lh...laph..spcp..............................Lh..ths.h.tph.........hlhtlpsh...................................ts.....hll.lu..Dlh.c.S.lhhl......tapt................-sp.....l..........hu.c..Dht.........s..t..h..ss...s..s..phl..Dt....c..sh.......lsuDp...................sNlhlhph..........s..s.psspp.ptp...................................................................................................+Lthhsp..aal..G....ch.ls.sh...p....ss....lh.......tpps..........................................................................................llau.T..l.p.GslG..hl...hs..l...scp..p........hchh.tl..ptp.lt..p.....h........................................................s..h...s.Gh.s..h...ta.............Rs..hh.s.......................................scshlDG-Lhppa..................................................................................................................................	1	286	462	673
+171	PF00313	CSD		'Cold-shock' DNA-binding domain	Finn RD	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.10	0.72	-4.19	40	14886	2012-10-03 20:18:02	2003-04-07 12:59:11	17	69	3908	61	3740	7958	3141	65.20	46	67.33	CHANGED	hpGsVKWFNscKGFGFIs.--Gst.DVFVHaSuIpssG.....a+oLpEGpcVpF-lpp..Gs+GspAsNVpsh	..............................pGpV..K.WF...Ns.p..K....G..F..GFIs.......s.......-..........s......G..........s..........t.....D..VFVH..a........SA..I.p.s.sG..........a.+oL......p..E.G.Q..c.............V.pF-..lpp.........Gp+G..s...p.A.sNVh..h.............................	0	1082	2120	2935
+172	PF04442	CtaG_Cox11		Cytochrome c oxidase assembly protein CtaG/Cox11	Kerrison ND	anon	DOMO:DM04116;	Family	Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein.\	 In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre.  Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units [1]. The C terminal region of the protein is known to form a dimer.  Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae (Swiss:P19516).  Met 224 is also thought to play a role in copper transfer or stabilising the copper site [2].	25.00	25.00	26.00	27.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.05	0.71	-4.42	135	1018	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	946	2	456	917	1462	143.90	41	68.61	CHANGED	hVP.LYclFCc.sTGhsGpTp..............t.ssstph...........ts..RplpVcFsAssssshPWcFcPpppplpV+PGEsshshYpApN.occslsGpAs.sVsPspAutYFsKlcCFCFspQsLpsGEph-MPVhFalDP-lscD.....lcslTLSYTFFcs	.....................hVPLYchhCp...sTGhsGpstp.............pttssp.............hsts.....Rp...l...pVpFsAssssshPWcFpPpppplp...............VpPGEsshshYpApN.o.scslhGpAshsV..sPtpAut.........YFsKl.pCFCFpcQpLpsGE.ph-MPVhFalDP-hspD.....lcslTLSYTFFc..........	0	129	252	360
+173	PF01148	CTP_transf_1	Cytidylyltrans; 	Cytidylyltransferase family	Finn RD, Bateman A	anon	Pfam-B_921 (release 3.0)	Family	The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast.  Sec59 is a dolichol kinase EC:2.7.1.108.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.96	0.70	-4.73	48	6283	2012-10-02 14:06:56	2003-04-07 12:59:11	15	17	4727	0	1821	4702	2431	255.40	24	86.77	CHANGED	htRhlsshhhlslhhhhlhhut..........hhhhhllhhlshhshhEhhphhthphhthhhhhs......................h.hhhhhhshhhhhh..h..hhthhhhhh.hhhhlhh.....................htthhhhhh.hhhhshhh.............................h.hht..htGhhhhlhshhllhssDshAYhhG+taG+p....hhPplSPsKTlEGhlGGhlsullhuhlhhhhht..........................................................hshhthlhlullsulhuhhGDlhcShhKRphtlKD.GphlPGHGGlhDRhDuhlhsuslhahhhhhh	....................................................................................................................................................................................Rhhsu.h.lhls.hhl.h.h.l.hhss...................hhhh.h.hh.h...h.l....s......h...luhh.E.hh...p..h.h.....t.h.p.t...h...p.h........h..hhh........................................................h..hh....h..h...h..h.....h...h....h.....h.............h...h.....................h........h...........h.....h.........h.....h......h.......h.....h....h....h..h.....h.h...h.lhhhh..........................................................t..ht.p..h..h...h...s..l..h...s..h..h..h.h.shhh.....................................................................................hh.h.h..t...s...h.........t....G..h......h...h....l.....l..h..h...h...h.l.lh..s....sDsuAYh.....h.....G.....+.....h......a.....G......+......+....Kl..............hP........p.........l.......S....Ps.K...ThEGhlGG.ll..s.uh...ll..u..h..h..h..s.h.h..hs...............................................................................................................................................................................................hs.hht...h.l.l.h..u.ll..h.u.l...h.u...hGDLh.EShhKRphG...l.K.........DS...G...p...llP.G.HG.....G....lLDRhDS..h........hhssPlhhhhh...h...............................................................................	1	615	1145	1531
+174	PF04145	Ctr		Ctr copper transporter family	Bateman A	anon	Pfam-B_3006 (release 7.3)	Family	The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane.  A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.	22.10	22.10	22.20	22.20	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.75	0.71	-4.14	116	1128	2009-01-15 18:05:59	2003-04-07 12:59:11	10	21	303	3	804	1068	7	123.20	22	63.53	CHANGED	MsMh....Fphsh.ssslLFpsWpss..otutahsohlhlhlluhhhchLchhppphcpthh......tp........thtt......t...............................................................................thphhtclhp.....uhLah......lphsluYh..LM.....LlsMoaNshlhlulllGh....slGhhhF	...................................................................................h.Mh.....F.hsh.p....hsl..laptWphp...............o..s..thhhuhlslhhluhhhEhLphhpt.ht..t.t.hh........tt.........................................................................................................................................................................................................................................................h..h.chhp.....shlah......lphsluYh..lM........LhhMoaNshlhlullhGhhlGhhh...................................................................................................................	1	242	446	686
+175	PF00394	Cu-oxidase		Multicopper oxidase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Many of the proteins in this family contain multiple similar  copies of this plastocyanin-like domain.	20.30	19.90	20.30	19.90	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.94	0.71	-4.33	72	9871	2012-10-02 17:41:00	2003-04-07 12:59:11	17	57	2516	325	2092	9906	260	140.70	23	37.09	CHANGED	cphslhluDWY.cpsspsh...h.ts............s..sDuhlINGpst...s....................................hhslsVpsGKpYRlRll.ssuspsshsFpIsuH.phollEs......DGsasp..Phss-slpIhsGQpaulllsA...sp.s...sssYaltst........h..s....htsssssulLcYpsu	........................................................................................................................t..hhlh.pDaa...pstps....h.p...h.t..tt.s...th...............................thhssp..h.lh..N.G.............................................................................................................................sss...h.s.s.p...sh..p...s..t.h.s...............p.l.h...ll..s..t.u...s.p...c.s....h....s......a.....hI..........s.........G........H..............h.l..ltu..........c.....G....p.a.ss..............s.h..s...l....-.....s.....h..h........l.t.s.G.............pthssl...hsh......pp............ss.Y....hhhs..........................................s....................................................	0	504	1249	1757
+176	PF03712	Cu2_monoox_C		Copper type II ascorbate-dependent monooxygenase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.	20.50	20.50	20.60	20.90	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.01	0.71	-4.88	25	590	2009-01-15 18:05:59	2003-04-07 12:59:11	10	37	157	18	376	631	214	149.50	26	25.41	CHANGED	pa.AGlhhLhsshh....sIPPspssash-ssC.hpp.scshaP......FAhpsHsHthG+hlsuhphRssp.....hphlu+psshsP..QtFYslc..phlcVpsGDtLsscCoY-op..sp.........spssthGtospDEMCshYlhYYs.....-ssphpshtsChustssp...hhpshssts	...............................................AGhh.hsh........hIPPsppsh...p.shCphpp..sp.hhs...............FAhhhH.....sHhhG+..tlps..h.phR.ssp.......................phphlscss.......sas......thQt...h.h.....lp.......p.lsl.hs...........GDhL.....hscCsasop....s+.............................spsThhGh..ssp-EMChhalhY.Ys......t...p.h..h....t..t................h....................................	0	189	216	300
+177	PF01082	Cu2_monooxygen		Copper type II ascorbate-dependent monooxygenase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.	21.10	21.10	21.60	21.50	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.20	0.71	-4.20	38	534	2009-01-15 18:05:59	2003-04-07 12:59:11	15	24	136	18	344	574	28	124.70	27	21.58	CHANGED	spph-lthpsl..hPsp.sssYaCphh+lss....p+aaIlpaEPlhst......shlHHMlLatCs......pshsp..................sstC.....h.tphthC.......spllhAWAhGutshta.PccVGhslGtst.s.s+allLEVHYss..sshpsups	.............................h...h-lhh.sl...hPpp..pssYhChhh...cls......pcpal..l.p.a.-Phhs................shVHHhll......at...Cs........psh.sph......................st.C...........hs.tph.t..sC................ppll..hAWAh.Gut....s..hph..Pc..csGhslGsss...sspYlhLplHYss..sth....th..........................	0	156	180	269
+178	PF02845	CUE		CUE domain	SMART	anon	Alignment kindly provided by SMART	Family	CUE domains have been shown to bind ubiquitin [3-4]. It has been suggested that CUE domains are related to Pfam:PF00627 [4] and this has been confirmed by the structure of the domain [5]. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2 [2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-7.57	0.72	-4.44	132	1581	2012-10-01 23:03:33	2003-04-07 12:59:11	11	43	284	10	1034	1491	4	41.20	24	8.01	CHANGED	ppstl..pplpphFPslspphIptsL.ppsssl-tslstlLphs	............thl..pplpphFPs.lspphlppsLt..tpsssl-tslspLLph..........	1	287	499	788
+179	PF00190	Cupin_1	Seedstore_11s;Cupin; 	Cupin	Griffiths-Jones SR	anon	Prosite	Domain	This family represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins.  Plant seed storage proteins provide the major nitrogen source for the developing plant.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.78	0.71	-4.76	225	3563	2012-10-10 13:59:34	2003-04-07 12:59:11	17	24	631	221	1395	6143	837	141.10	18	62.47	CHANGED	hshtpssp....hhpspuGtl...pthsspphs.hhtphthsththth.pssulhsP+ap..sAspllaVhcGpuhhshlssss...........................................................................................p.hppc......lppGDlhslPtGhshhhhsst..psshthsshssssss...................lst.hhtpsFhlusppsp	........................................................................................................p.t.su..h...p...h.s.s..pphs........tth..t..h..s..tsth....h.tss.u.h.h.....P...Hap..pA..s....c..lhal...l...p.G.......p..uhlsh.l.ssss......................................................................................................................................ph.hspp......lptGD..lhh......hPt..G...h..s..a.a.h.h...s.......s........t......s....s...sh..t.l..h.h...h..p...sss..t...................................hs..hh.psa.hs..................................................................................................	0	198	814	1141
+180	PF04889	Cwf_Cwc_15		Cwf15/Cwc15 cell cycle control protein	Mifsud W	anon	Pfam-B_6589 (release 7.6)	Family	This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologues. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing [1]. 	27.20	27.20	28.10	27.50	27.00	27.10	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.91	0.70	-4.66	30	382	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	282	0	279	376	9	193.80	37	96.06	CHANGED	MTTAHR....PTac.PA+GtpspuG......otpasSRsLPuHTpLK...........hRps.GQssp-ch.......t...p+DLRsEL.ctEtpptscc..........................thhth-stspppshch....spcp.cc..h.........................K+.h.............tpspshDADc........tp.............ssssD--.................uD...........s--DEsttLhtELE+IK+ERtEcct+c-cEtttpctcp+cpclhpGNPLLN.................ttssFslKRRWDDDVVFKNpA+s..cpt+c.pFlNDslRS-FHKKFhsKYl+	...................................................MTTAtRPTacsAp.Gtpst..tt........otthpsR.LP.uH...........TplK..................hRps..sQ.s.....s.t-h.................p..t+-h+tEL.ptEttthtpp...................................................ttt.t......t.t.................................................................................................st..shDuDs.s..............................................tppp-p-................tc.........psc-D-s.ttLh..tELp+IK+ERtpcpt+cEtcpttp-tc.+.tplhpGNPL.LN.........................tsh..plKR..RWDDDV.V..F......K...NpA....+u....cptc......c....FlNDhlRS-FH++FhpKYl+.......................................	0	99	157	228
+181	PF04677	CwfJ_C_1	CwfJ_N_1; 	Protein similar to CwfJ C-terminus 1	Kerrison ND	anon	DOMO:DM04663;	Family	This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909).  CwfJ is part of the Cdc5p complex involved in mRNA splicing [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.63	0.71	-4.46	8	549	2012-10-01 23:45:21	2003-04-07 12:59:11	10	23	278	0	412	1265	265	125.80	29	20.81	CHANGED	spcp++hpps.csChFClsssslccHLlVSlGppsYluLPc.ssL...........spsHslIlPlpHhsss.hols-....-lh-EIppF+KuLstM.asupspDslFaEhs...spRs.HhplpsIPlPpphuch..ushhFp	..................................h...pp.ttt.spChaC....h...s....s.....s.....p.....h.....t....p...H....l...ll.o.l.Gsc.............sY.L.s..lsp..ssL....................ssG..HslIlPlpH.hssh.......sphsc................-sh.c......E....l....p......p....a.....+....p....u....L....p.c..M.....a..p....s.......p....s....p...s.......s.......l.....h..a...Eps..............t+.p......hHhthps.....lP..lPtphsphh...a............................................................	0	144	225	337
+182	PF04676	CwfJ_C_2	CwfJ_N_2; 	Protein similar to CwfJ C-terminus 2	Kerrison ND	anon	DOMO:DM04663;	Family	This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909).  CwfJ is part of the Cdc5p complex involved in mRNA splicing [1].	21.30	21.30	21.50	21.30	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.14	0.72	-3.50	48	528	2009-01-15 18:05:59	2003-04-07 12:59:11	9	19	269	0	399	536	6	99.10	26	16.57	CHANGED	castpt.hchtshpt...........hp..hspshsYFhVpls......................hsp..shhphl-.....................cpp..cFslp..FuRcVlus..lLsL.pRhpW+c..stpsppcEctcstpF+ptacsF.DaT	................................................h.ph.t.........pshcp..hs.pshsYFtVphs.............................hss....shs.Hhlc..............................................cpt..c.FPhp..FGR..-Vluu..hLs.lt.s....+...tW+p.....sppstc-cppcstpF+ct..ac.aDaT..........................	0	140	219	326
+183	PF01705	CX		CX module	Hutter H, Bateman A	anon	Hutter H	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 6 conserved cysteines that probably form three disulphide bridges.	25.00	25.00	25.80	26.40	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.31	0.72	-4.00	14	114	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	8	0	108	106	0	59.90	32	25.21	CHANGED	YYWsspa....lpsscpP.shCEYpIs-..-DtELpNVsFsNGo+PpSlhFuCsst.ppCCGh-CCssh	....................YYWttta.......hts.pts..hCpa.lsp..pDhp..lpslpFssGop...P.pslhFuCtts.ppCCGhcCCt.......	0	30	40	108
+184	PF04673	Cyclase_polyket	cyclase_polyket; 	Polyketide synthesis cyclase	Mifsud W	anon	Pfam-B_5596 (release 7.5)	Family	This family represents a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.	23.70	23.70	25.00	53.00	23.30	23.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.28	0.72	-3.95	23	122	2009-09-11 03:24:20	2003-04-07 12:59:11	7	2	90	1	40	120	0	96.20	46	87.19	CHANGED	MsPususcVAclFuEpD...sTELP+lhGspRRpLFpa+s.LYFHLh-.ssscssssltpA+sHPpFhclSccLpsalssYDP.sTWRuPpD.AMAppFYpWsA	.....MsPususcVAclFA-SD...uoELP+hhGVpRRpLFpacs.LYhHLlE..s....c....csssttltps..+.s..cP...cFhclSccLpsalssYDP.tTWRuPpD.AMAppFYpWp...	0	10	30	38
+185	PF00134	Cyclin_N	cyclin; 	Cyclin, N-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.54	0.71	-4.57	127	6213	2012-10-03 00:42:12	2003-04-07 12:59:11	18	86	547	190	3707	6602	83	123.90	20	31.34	CHANGED	-IapahpphEtp...t.s.saht.pp.....ls..pMRsILlDWLlc.VppcacLh.ETLaLslshlDRFLutp......l.+pcLQLlGlsuhhlAuK........aEEh...............hsPplp-ashlo.....Ds.sas...............pcpllpMEphlLpsLpapls	......................................................................................................................hp....th.Rt.h.h...h...p..a....l............h..........p........l..t....p.p....h...p...........l........t..t...p..T.h..h.h...u.l......s.....h.h.......-.......R...F......htpt..s.....................lpp...p....p......h.......p...L....l....u......s..ssl.h..........l.....Au...K.............................h..E..Eh...................................................s.s..p.l..p.c.h..h.....h.hs.........cp..shs.................................................tpp..lhphEh.hlLpt.Lpapl.......................................................................................	0	1218	1928	2867
+186	PF02276	CytoC_RC		Photosynthetic reaction centre cytochrome C subunit	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_5109 (release 5.2)	Family	Photosynthesis in purple bacteria is dependent on light-induced electron transfer in the reaction centre (RC), coupled to the uptake  of protons from the cytoplasm. The RC contains a cytochrome molecule which re-reduces the oxidised electron donor.	22.40	22.40	22.50	26.80	20.30	22.30	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.26	0.70	-5.32	25	104	2012-10-01 23:37:15	2003-04-07 12:59:11	13	3	88	20	28	104	73	250.30	32	79.94	CHANGED	h.ppP.ss-shQoG.RGsGMptsp.scslsp.sss..shss.stsssss..usPpAu-lYpNVp.VLGDLosupFsRLMsAhTpWVu.Pc-GCsYCHss.p..sausDshYTKhVuRpMlpMTQplNssWss.HV...upsGVTCYTCHRGpPVPstlWap..ssshssuhtGhsssQNtuss..............ss.saoSLPsDshp.aL....L-.....scsI......+Vpshsuhs...ssssc...s.lppAEhTYuLMhHhSsSLGVNCTaCHNoRAFa-W.sQuTPQRssAahGIcMVR-lNssYltPL.pshhPspRLGPh.GDssKlsCtTCHpGshpPLtGsshlcDaPELAss	.......................................P.....s.QhG.RGhuh......t...t......t..s.s...s....stshAsp.hapNVp.VL.tcls.spFs+lMsuhopWlu...pps..CsYCHs....t.......shAsDshapKhVuRpMlpMTpplNs...pW.....ps..Hs.......stsG....V...oCYTCHRGpshPt.hW...hp.......tt.h....t..ps..t.................s.thsuLP.Dshp.aL.....t......tt.l......pl.s........puhs.....t..tt...s.hppsEhoauLM..ahSsuLGVsCsaCHNopsFhsh.p..p..ssPp+shuhhulpMsp-lNtpah.sh.t..hPt..phh......G...s-s.+hsChTCHpGh.pPL.G..h.phhtpa..L..s...................................	0	14	24	25
+187	PF05038	Cytochrom_B558a	cytochr_b558a; 	Cytochrome Cytochrome b558 alpha-subunit	Moxon SJ	anon	Pfam-B_5327 (release 7.7)	Family	Cytochrome b-245 light chain (p22-phox) is one of the key electron transfer elements of the NADPH oxidase in phagocytes [1].	25.00	25.00	26.50	25.80	21.30	23.30	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.15	0.71	-4.66	4	85	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	62	1	43	84	0	159.20	60	95.33	CHANGED	GpIEWAMWANEQALAoGLILlsGGIVusAGpFppW.FGAYuIAAGVLVCLLEYPRGKRsKG.oThERsGQ+hLTtsVKshGPLoRNYYlRAhLHLulsVPuGFlLATILGssCLsIASlIYLhAAl+GEpWpPI.s+.c-.Rs.VGtoIKpPPoNPPPRPPsEhR+KsuE-.sssA.........NPhsVTspsV	............GpIEWAMWANEQALAuGl.lLlsGGIVu.......sAG.pFptW.F....uA...YuI..sAGVhVCLLEYPRG.KRpKG.oTMERsGQ+YhTslVKhFGPLT...RNYYlRAhLHhh.LuVPuGFLLATILGTsCLuIAShIYLLAAlRGEpWp.PIE......s.+scp..RsplGsoIKpPPoNPPPRPPs-sR+K.s-t.t.ss...........NPhsVp....................................	0	14	17	26
+188	PF01820	Dala_Dala_lig_N	Dala_Dala_ligas; 	D-ala D-ala ligase N-terminus	Bateman A, Moxon SJ	anon	PSI-BLAST 2dln	Family	This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding [2]. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF) [3].	21.60	21.60	23.00	21.60	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.29	0.71	-3.78	176	7730	2009-01-15 18:05:59	2003-04-07 12:59:11	16	22	4347	83	1553	5359	3003	82.10	29	32.44	CHANGED	h+..lullhGGpSsE+-VSltSApslhpuL....p.p..ppaclh.......l.hls.cpG.tahhhtt..t.ht..t......................................................htphDllFslLHGs..hGEDGslQGlL-hhslPYsGs	............................................................plsllhGGhSsE+plSl.Sutslhtsl..................p......tth.p.sh...............h...h.....p....t................................................................................................................................................thsh...ha.hlHG....GE..DGslQGhhchhtlPasGs........................................	0	540	1043	1317
+189	PF01113	DapB_N	DapB; 	Dihydrodipicolinate reductase, N-terminus	Finn RD, Bateman A, Studholme, DJ	anon	Prosite	Domain	Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated  cyclic imine, dihydro-dipicolinate.  This reaction is the  second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both  protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.49	0.71	-4.20	99	5206	2012-10-10 17:06:42	2003-04-07 12:59:11	15	17	4187	43	1251	5533	3347	112.90	28	41.03	CHANGED	l+lslsGAsGRMGppllcslpp.p......sshpLsuul-css......t.shs...........t.....sl.l...sclppshsp..sD..........VllDFT.pPpushpplchshpt.shshVlGTTGa...opcphpplpp.hu...cc..lsllhusNa	........................................h+lslhG.stG+MG....p....t.l.l.p..slt.p...t........p.s..h.p.L..s..u..s..l-pss...............................................................t.ht......h...s...l.....l............ss..l..s...s.l.hsp.........sD.......................................V.ll.......D.F.......T.....p..P..p...s....s........h.....p..p...l..p...h....s...h...pp...s..........h.....s......h.V..l......G...T.T.G.h........sptt..h..t...t.lpp...hu...pp..........hsh.lhusNh...........................................................................................	0	372	808	1057
+190	PF01682	DB		DB module	Hutter H, Bateman A	anon	[1]	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig Pfam:PF00047 and fn3 Pfam:PF00041 domains, as well as in some lipases Pfam:PF00657.	25.00	25.00	28.80	25.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.97	0.72	-11.48	0.72	-3.96	26	351	2009-01-15 18:05:59	2003-04-07 12:59:11	14	38	33	0	314	315	0	96.30	27	28.50	CHANGED	CCpspt.lsstChp.hCsapsh......h.shhhtsspCsh..phsplhpCAupscDHosCCtcpuVs.......spChshCp.p.s......hsshthshhsChp.phsshhpCFh	..................................CCppps..l.sstChs.hC..sapth.......................p.h.hhtsspCsh..phsphhpCAup..G..+.............D..HopCCt..cpGls.....................spChshCpsp.s......hsslthshhsChp.thpshhpCa............................................	0	111	144	302
+191	PF05011	DBR1		Lariat debranching enzyme, C-terminal domain	Wood V, Bateman A	anon	Pfam-B_9676 (release 7.6)	Domain	This presumed domain is found at the C-terminus of lariat debranching enzyme. This domain is always found in association with Pfam:PF00149.	21.10	21.10	22.50	21.40	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.26	0.71	-4.31	24	333	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	279	0	244	330	6	132.20	28	26.79	CHANGED	lPc....os+s..T+FLALDKCLPtRcFLQll-lsstsss............hpLpYD.EWLAIh+shsphhp......l.sshss.sstspG....c.tacshhE-ppphVpEcl.ttscLpl.PcNFshTAPsacsu..sth...sst.PstatNPQTspFCcLLGlcshh	.....................................h......tsps...T+FLALDKCLPc....R...c....F.....LQl..l-ltstssss............................................pLpYD.EW...L.....uIh+shpshhs..............................l.t.p.........stp.t..................hts.....p.pthp.l..pp...l...........t...t..p......htl....P.p....sF.....T.ss.s.ass....s...............................hhNPQTttasthlsl....h.......................................................	0	86	135	205
+192	PF03107	C1_2	DC1;	C1 domain	Bateman A	anon	Pfam-B_16 (release 6.5)	Domain	This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in Pfam:PF00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions.  The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.83	0.72	-3.83	90	558	2012-10-02 13:15:50	2003-04-07 12:59:11	11	57	24	0	370	664	0	31.30	34	11.07	CHANGED	hhCslC.c+phssh......hYpC.ppss........aslHsp.Cu	..........CslC.ccp..lssp.....hhYpC..pcCs........aslHsp.Cs.	0	312	351	358
+193	PF00383	dCMP_cyt_deam_1	dCMP_cyt_deam;	Cytidine and deoxycytidylate deaminase zinc-binding region	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.79	0.72	-4.37	59	17292	2012-10-02 00:10:39	2003-04-07 12:59:11	17	96	5079	154	4759	12505	5590	105.20	26	47.17	CHANGED	hp.cchhhphAhthAppuh..stsphsVGAllVp..sspllupGhNtp.tuts......................................................shHAEhsAltpAsp....t.ph........................s..sslal.............ThpPCs.h......Csphllpt.u.lp+Vlhst	..................................................................................................................................................p.hhphAlp.h.Appuh.......st.sphsV.G.A.ll..V...........p....................s........s........p..........l...........l..........u.........p..G.h.N.t.p.....t.s.ts.............................................................................................................................s.hHAEh.p...Alpp......Aspt....t...t.ph............................................................................................................t.s.....sslYV.......................................T.l...pP..Csh................Cspsll...ps...t..ltclhhh.t............................................................................................................	0	1638	3063	4050
+194	PF05026	DCP2		Dcp2, box A domain	Wood V	anon	Pfam-B_10622 (release 7.6)	Domain	This domain is always found to the amino terminal side of Pfam:PF00293.  This domain is specific to mRNA decapping protein 2 and this region has been termed Box A [2].  Removal of the cap structure is catalysed by the Dcp1-Dcp2 complex [3].	28.00	28.00	29.10	29.90	26.80	27.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.02	0.72	-4.09	23	313	2009-09-11 21:45:37	2003-04-07 12:59:11	8	12	259	7	225	319	2	85.10	41	13.28	CHANGED	cchL-DLssRFIlNlPpE-LsolERlhFQlEEApWFYpDFlR.hsP..tLPshsh+sFupplhp+....CPLl.pa......ttshcpALpcFtpYK	...........clLDDLssRFIlNlPpEE...l....p....sh.........RlhFQlEpAaWFY.DFhp.............t.......t.s......P......sLP.sh.s.l+sFut..t.............l.F....p+......CPh..Ltta......ttchcchhpcappYK...............	0	83	130	190
+195	PF03607	DCX		Doublecortin	Griffiths-Jones SR	anon	PROSITE	Family	\N	21.40	21.40	22.10	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.58	0.72	-4.38	53	1063	2009-01-15 18:05:59	2003-04-07 12:59:11	12	41	119	7	602	931	2	60.20	32	14.44	CHANGED	lllsp.+phpoa-slLsclTc....plpLs.tG.VRplaThcG.+plsslcc.LpsGpsYVsu.upE.tFK	......................hhlsp.+ph+oF-slLs-lTc.......tlp..L.....s...pG..V+plY.Th-G.+p.....l..ssLp-..l...t..-...u.ps..aVss.u..E..F+...........	0	142	196	349
+196	PF03455	dDENN		dDENN domain	Callebaut I	anon	Callebaut I	Domain	This region is always found associated with Pfam:PF02141. It is predicted to form a globular domain [1]. This domain is predicted to be completely alpha helical. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family [1].	21.10	21.10	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.47	0.72	-3.90	46	1393	2009-01-15 18:05:59	2003-04-07 12:59:11	14	84	197	2	782	1322	6	70.50	27	5.94	CHANGED	lsp.plpcsFLphhsp..lhtsYcsalph.p..tt...............tFpppuFlcs.pspshp.....pFlpphhco...QhFspFIcc+	...........................sttlptsFl+hhsp...lht..s......Y....c.palphhp...tt.p............................................sF.pp....p.uFLps...psps.p.......pFl.pphh.cT...QhFttFIpp+............................................	0	198	284	494
+197	PF02791	DDT		DDT domain	Iyer LM, Aravind L, Bateman A	anon	[1]	Family	The DDT domain is named after (DNA binding homeobox and Different  Transcription factors) and is approximately 60 residues in length  [1]. Along with the WHIM motifs, it comprises an entirely alpha  helical module found in diverse eukaryotic chromatin proteins [2].  Based on the structure of Ioc3, this module is inferred to  interact with nucleosomal linker DNA and the SLIDE domain of ISWI  proteins [2][3]. The resulting complex forms a protein ruler that  measures out the spacing between two adjacent nucleosomes [2].  In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket [2].	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.84	0.72	-4.20	42	658	2012-10-07 04:36:59	2003-04-07 12:59:11	12	81	241	0	419	641	5	61.50	26	4.04	CHANGED	sp.shschL......tlacFLpsFuclLpLssF.....oh--FtpAltspssp....LhsElHhsLl+h..llps.ps	............s.pthuchL................hlacFLpsFuclLtLs.sh...................ol.-.s.h.ppAL.......h.spssp......................hhsElphsLL+h..lhpt.t.....................	2	113	213	327
+198	PF00270	DEAD		DEAD/DEAH box helicase	Bateman A, Bruskiewich R, Sonnhammer ELL	anon	Published_alignment	Domain	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null --hand HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.48	0.71	-4.76	182	63415	2012-10-05 12:31:07	2003-04-07 12:59:11	24	708	5596	153	23464	73599	16995	166.80	22	21.58	CHANGED	osl.Q...tpsls...hlh..p.s............cD.ll........stutTGoGKThsahl...shl...ptlht............................................................................................................t................................................................................................................pslllsPT+pLspQhhpph...pphhph..............h.l...........psshl...hG........shs..hp.pptthl.........ps.scllluTPsc.....lhshlpp....th.th........hp.lph..lVlDEscphhs.........sats....plpp......lhpt..h....................t.................hp.hlhhSAThs.pslpcl	............................................................................................................................................................................................................................................................Q...tp..s.l.........hh......p..s...............................ps....h..l.....................st.u...t..T...........G...o....GK............T.....h.....s...h..h..l........s.h..l........p..t..l.....pt...t...........................................................................................................................................................................................................................................................................................................................................................................psl..l...l...s...P...s...+.....t....L.......A...t....Q..........h.......h.......p...p....h...........p.p..h.h.tt................................t.h.......................................................ps.s..hl................hG...................................s.hs.........hp.......p..p...hphl...............................pt.t....s...c..l.........l....l..u.....T.s..ut.............................l..h..s...h...lpp...............h...th..................................pp.....l....p....h.........l.........l.l..D.E...s..c..c...h.h.s..................................sh.t..................................p.l.p.p..........................lh.ph.....h.....................................p........................................hp..hlhh..S.A.Ths..tt....h...................................................................................................................................................................................................................................................................................................................	0	8187	14068	19550
+199	PF00531	Death	death; 	Death domain	Bateman A, Griffiths-Jones SR	anon	Reference [1] and [2].	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.70	0.72	-4.21	88	3125	2012-10-01 21:41:45	2003-04-07 12:59:11	17	542	171	79	1743	2836	0	80.60	19	10.09	CHANGED	pplhphl..sphhsppWpplu.cpL...slspsplcphcp...ps......ptshplLptWtpp......puolssLhpsLpphstpcssct.lpphh	................................t......h....sp.hspsW...p..pL....A..ppL.......sh.s..ppplp..tlcp.............pp...t....ptshp...lLptWtpp..........t.....t.s......u..........s......l.......s..p..LhpsLpp..hs..ppchsc..lt...t..........................	0	804	885	1205
+200	PF04626	DEC-1_C		Dec-1 protein, C terminal region	Kerrison ND	anon	DOMO:DM04594;	Family	The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1]. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). Alternative splicing generates different carboxyl terminal ends in different protein isoforms, so this is region is the most C terminal region that is present in the main isoforms.	25.00	25.00	88.40	36.70	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.84	0.71	-3.99	2	24	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	11	0	11	30	0	120.90	52	10.72	CHANGED	MPSMMQREVEDEDNKAEDDLVGEAGPQMPENEGTARHKVDALGVGGNKRKKSKSKSAPPTVINYYYAAPQRPVVQSYGTSYGGGGYGSNAYGVPRPVNSYQSQGYRAAVGNDEVDEMLRQHQTMARTINPKQ	....................t.....Qpt.p.tppsct.p..-sll.GEAtPQMPEstGpARHK.VDhLGlGGs+..RKKSK....upou.PsVINYYauuP....p.............h...........h.....s.............SYGTSYG...GGGYGS...NAYGs..........h.s...NsYQ...t......GYR.AAVGNDElDpMLRQHQTMAps......p...............	0	3	3	8
+201	PF02141	DENN		DENN (AEX-3) domain	Mian N, Bateman A	anon	IPR001194	Family	DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways [1].	23.40	23.40	23.40	23.40	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.14	0.71	-4.57	40	1791	2012-10-02 14:18:06	2003-04-07 12:59:11	16	97	243	2	1055	1806	19	178.90	27	16.35	CHANGED	hsPcshCllS+hsahssF.cchLstlhphhtpus..............hslcsaltshltpsshPsPGpshph.p...husp-hhhhspPt.sspL..Ph..pssshp.....tLapsLuscNllpLasssLh.Ep+IlhhSpchshLopsscAlsuLLaPhpWQasYIPlLPspLl-sL.sAPsPFllGlpuphhs.....hhps.s-lllV..DLDss	......................................................................................................................................h...pshsl.lS.p.hshhpha.p..........c...hLt...lhphhh.ps.......................................................l.p.t...h..l..tp......l..hph.s...h..P.s.s....u..ps.hhh...........................ts.t.thh..h..h....pt..P......sspL.......sh.......pshsh.p.........................l...h..p.tL.u..l..c..sl..l..p........lh.....sshLh..Ec+l..lhhSp.ch.................s..h......Lo....t.ssc...u........l..su..ll..........a..P..hp....W...p....a...s..a...IP...lL..P..s...p.....h.....h...c.........h.l....s...............u..PsP.........al.lGlp.u..p..hhp.....................t-l..l.hl..DlDs.............................................	0	352	490	745
+202	PF00610	DEP		Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Ponting C, Schultz J, Bork P, Martemyanov K, Thorner J	anon	SMART	Domain	The DEP domain [1] is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell [2-3]. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting [4-5]. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit [6-7].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.43	0.72	-4.23	133	2616	2009-01-15 18:05:59	2003-04-07 12:59:11	16	134	308	16	1545	2411	15	72.20	25	9.41	CHANGED	ulplpcc+h..thps..atpsFsGs-hVcWLh........h..pt.htsRpcAlpluptLl..............ppGhlpplpscp.t..............Ft-s.thhYpF	.......................lps+ch...hh..ps..h..psF...s.....G.s...-lV-WLh......................p.h.....p....hps.RpcAlpluptL.l....................................................cpG..hlpp.lssct.p...........................Fp-s.thhYpF.....................................	0	410	638	1072
+203	PF02272	DHHA1		DHHA1 domain	Bateman A	anon	Bateman A	Family	This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members [1]. This domains is also found in alanyl tRNA synthetase e.g. Swiss:P00957, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.	21.20	16.00	21.20	16.90	21.10	15.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.45	0.72	-4.27	133	12856	2009-01-15 18:05:59	2003-04-07 12:59:11	14	38	4786	16	3060	9901	3277	66.90	22	10.25	CHANGED	ppsllhhs......pssphpsssRs.pslshp.......pllpphtt.hsh...tGGG+spsAuushppsp...........lpphlptlpp	...................................t...hllhs.........ttss....p...l...p...hssR....S..h.ps..lshp...........pllc.ph..t........h.h.....pGGGHsts..A..us.s.hpsss.............lpphhpth..t...........................	0	1073	2042	2615
+204	PF04922	DIE2_ALG10		DIE2/ALG10 family	Wood V, Bateman A	anon	Pfam-B_9570 (release 7.6)	Family	The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterised in rat as potassium channel regulator 1 [2].	19.70	19.70	29.00	23.10	18.30	18.20	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.52	0.70	-5.44	5	365	2012-10-03 03:08:05	2003-04-07 12:59:11	7	9	246	0	265	367	4	294.00	27	77.66	CHANGED	s+hVPEPYMDEIFHlsQAQpYCcGcao..pWDPhITTPPGLYllSlu...sLpPu..hhusSsloh........LRhlNhLsuV..hhhshLlhRhIplhN.t.u..slsahAloLusaPlLaFFoFLYYTDluSlhhVLhuh...LshsaGsh+s...SAFhuslSshF....RQTNIIWsuFlAso.hhs.phu.tp.pllQcphs-...........LRohlpaLK.........hFl+.....SlccFSsLlL.....................PYhhlhluFhlFllWN.GuIVLGDKSuHpAuLHluQIFYFhsFsAhFSaPhaISsNhl+Hh++p..lp+phsppShlllulVhLlsaF.ThVHPFLLADNRHYTFYlWRRllsp..+hlh+ahLsP.......uYlauh....ashtslosp...........hs+loWpLLahlsTlloLVPuPLlEFRYYILPYllWRL	.............................................................s.......ah....DEhFHl.Qs.tYhp........t.....pa.............WDshITT.PGL....Yh.h.uhh............h.sh..h......t..h..s.....................................LR.hs..h..hh..h.......h..h..hh.h.....p.......h............................h...t........................................................................................h..........s....h....s..l.....hhP.haha.hLaYTDhhShhh....ll..h...................h....h...........t.....h.....................s.s.......h....h...u.hh.......uhhh........RQTNlhWhh....h.h.hs................................h..........................................................................................................................................................h...........................................sah.h.hhhFhhFlh.hN.tulsl..................Gc+ptH.s.s..hHhsQhhYh...hhh.h.h...s.h....s...h............h...........................................h......h..............................h.........................................................h........h........h............h....h....h....h........hhh..ohh......H.ahLADNRHYhFYlaphhh............hhthh..hhs.......................hYhhsh...........h..h.h...h......................................................h.......hh..h..h.shhhshhst.LhE.RYahlPhhhh......................................................	2	82	142	217
+205	PF01843	DIL		DIL domain	Bateman A	anon	[1]	Family	The DIL domain has no known function.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.40	0.72	-4.15	56	1158	2009-09-11 05:00:57	2003-04-07 12:59:11	14	77	276	3	698	1062	2	99.80	30	7.74	CHANGED	plhsQLapaIss.hhNsLlhR+sh...soappGhpl+.hslspl-cWscstshpts...shppLcplhQAspLLpl.pKpphp.-hchltphCs...sLsstQlh+llstYpssshp	.................................QlhsQlFhhlss.hhN..........s.Llh..R+ch..................soasp.Ghpl+.hsls.pLE.cWhcs...ps.......ht.u.................uhppLp............l.hQAspLLph..p.....K..tp.p...shphlpshC...........................tLost.Qlh+lls.Ytssp..t.......................................................	0	167	330	521
+206	PF03018	Dirigent	disease_resp; 	Dirigent-like protein	Griffiths-Jones SR	anon	Pfam-B_835 (release 6.4)	Family	This family contains a number of proteins which are induced during disease response in plants. Members of this family are involved in lignification.	27.60	27.60	28.30	28.30	25.30	27.40	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.86	0.71	-4.68	86	847	2009-09-13 07:42:01	2003-04-07 12:59:11	9	14	70	0	466	810	1	136.60	29	66.27	CHANGED	phscl+hYh.HDhls......G.sssTu.stVssssssst.................tFGslsVhDDsLTcGsshs..Sp.h....VGRAQGhYlhsupp.sh.....shhhuhohVFss..Gcas....GSTlslhGts.h.hsps..REhslVGGTGpFRhARGashh+Th.............phpssssllchs.lplh..h	..........................................................................................phphYhH-hht...........u.sssos.s.lstsstss..............................hFGs.l.sVhDDsLTpGss.hs........Sp..h........VGRAQGhYhhs.u...ts...sh....shhhshs.hsFp....s...s..cap............G...STlslhGt.s.......h..hsps....+Eh.ulVGGT..GpFphA+Ga...shhpoh.............t.tsssshhchslhl.........................	0	35	260	373
+207	PF02377	Dishevelled		Dishevelled specific domain	Mian N, Bateman A	anon	Pfam-B_1381 (release 5.2)	Family	This domain is specific to the signaling protein dishevelled. The domain is found adjacent to the PDZ domain Pfam:PF00595, often in conjunction with DEP (Pfam:PF00610) and DIX (Pfam:PF00778).	19.70	19.70	19.70	19.70	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.64	0.72	-3.77	4	215	2009-01-15 18:05:59	2003-04-07 12:59:11	10	14	74	0	107	198	0	70.60	48	10.92	CHANGED	pR-RsRRRsp.EpAshhpGpsh.GcpcRcsus.h-SSSTlLSSELEooShhDS-EDDohSRhSSSTEQSSuSRL	.....................pRERsRRRpp.....E.cs...s....+.h...NGps..t...u.c.p..c..R...c.hu.u....h-SSSTlMSSELESTSFhDSDEDD.o..h.S...RhS......SSTEQSSuSRL.....................	0	17	27	58
+208	PF02916	DNA_PPF		DNA polymerase processivity factor	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	25.10	26.10	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.20	0.72	-4.00	11	530	2012-10-02 11:47:48	2003-04-07 12:59:11	10	9	359	26	20	382	453	114.60	54	23.78	CHANGED	hKhpKhThslLh.huhlsusshhuhtphl..hs+hsssosYSE..hshSsllstDssIpDlsplpSlluPsssDs-.....lstlpp.stslplssspos.sa.sA.pShlsucs+ulVh	..............KKAcKFTlhLLVhSlLVSSVoLFAlQQFVsLTNRLNuTSNYSE..Yol..SVsVhADS-IcNVoQL..o..S..Vs..APTus.DsENI.pcLLuDIK.o.opssDLTVs...p.So.SYLAAYKSLIuGE.oKAIVL...........................................	0	2	4	14
+209	PF01965	DJ-1_PfpI	ThiJ; 	DJ-1/PfpI family	Bateman A, Enright A, Ouzounis C	anon	Enright A	Family	The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. This N-terminal region of the full-length AdpA proteins is necessary for dimerisation of the molecule.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.94	0.71	-4.74	39	9251	2012-10-03 00:28:14	2003-04-07 12:59:11	19	42	4024	121	2389	11671	1005	150.20	21	67.66	CHANGED	plsslusppst......hpsp.s...........hplpsDtslsclsspp........aDslllPGGhssscpLt............ttlhchl+chhpp.uphluAICpuP.hlLhsssllp....................G++hTua.shps........hpttstphh-..t.Vs....hss.............llTutssssshpFshpllctLt	................................................................................t.........................h.t.t.t.................ht.l.t..s..s.t.s.......l..s..c.l.p....s.sc....................aD.ull..l.P....G.....G...h.u...s..s..p....s..Lp.c.....................................ppl.h.p...h....l.....c.p....h....h..........p..........s.....s..........K............lu...A.lCpuP..th....L....s...s.s.....s.l.hp.........................................G.+.p..h.T.u...a..s....s..h.pp..........................th.p.t..h..u..s...p..a...h...c.............t...tss.......................hDt............................................pllTupsPsss.thuhtllp.l............................................................................................	0	717	1413	1949
+210	PF00751	DM	DM-domain; 	DM DNA binding domain	Bateman A	anon	[1]	Family	The DM domain is named after dsx and mab-3 [1]. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains.  The DM domain has a pattern of conserved zinc chelating residues C2H2C4 [2]. The dsx DM domain has been shown to dimerise and bind palindromic DNA [3].	21.70	21.70	22.20	21.70	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.05	0.72	-4.43	26	1027	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	215	1	380	930	0	45.10	62	16.36	CHANGED	RsPpCuRCRNHGl.hs.LKGHK+h.Cpa+sCpCpKCtLlt-RQ+lMAAQ	........R.PpCARCRNHGl...hosLKGHKRa.Cc..........aR-CpCpK.......CpLlsERQRVMAAQ...........	0	112	146	271
+211	PF01068	DNA_ligase_A_M	DNA_ligase; 	ATP dependent DNA ligase domain	Finn RD, Bateman A	anon	Pfam-B_788 (release 3.0)	Domain	This domain belongs to a more diverse superfamily, including Pfam:PF01331 and Pfam:PF01653 [3].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.23	0.71	-4.95	46	3956	2012-10-02 00:43:09	2003-04-07 12:59:11	16	83	2053	23	1751	4137	1269	187.60	23	33.16	CHANGED	PMLAp.hp..shtphhtph...................ttshhsEhKaDGtR..splH..t.pssphphaSRshcshTt........phsclhphlt.pthhssh.p..hlLDGElls..hs.pptphhPFttltp+h.+pph..........t..............phslshalFDlLhh.........sGps.L.......hphslpcR+plLpphh...................psclhlspthpssshc-lpchhcpslppGtEGlllKs...ssuhYcsu..+R.spsWlKlK	.................................................................................................................................stsahhEhKaD..G.hR........s.ht....................h...ps.....s.......p........h........plh.S......R....s....sc.shos..................................th.s.p.l..h...t....hh..........th.....h...........h..........t..t.............p.............hlLD..G..Ells.............h........t..p.........t.....t......h...h.s...F.pt.ltpp.h......ptph...................................................................phtlphhsFDllhh..................................sG.ps...l....................hph...sh...pcR.+...p...h...L..cp..hh......................................s..s..s.p...h...p.h..s....t...t......h...............s......p............s..............p...p.........h..t.......p.........h.......h.....p........p.......s....h.......p.......t...u.......h.......E..GlhhKp..............hsu...Y.....psG.....+R.....tsWhKlK..................................................................................................	1	555	1043	1451
+212	PF04679	DNA_ligase_A_C		ATP dependent DNA ligase C terminal region        	Kerrison ND	anon	DOMO:DM04655;	Family	This region is found in many but not all ATP-dependent DNA ligase enzymes  (EC:6.5.1.1).  It is thought to constitute part of the catalytic core of ATP dependent DNA ligase [1].	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.41	0.72	-3.58	150	2662	2009-01-15 18:05:59	2003-04-07 12:59:11	10	60	1269	10	1353	2742	442	102.70	27	15.67	CHANGED	ppsth....GuLLLusacs...........sp.......LthlG+VGTGFsspphpcLtppLp.slt.....tsps.Ph...........t........sshW.l..........cPpl...VsEVpa.s-hTts..................G.....pLRaPp.ah.tlRpDK	........................................tuhhuuhLlGsacst...........................sp.......................................hhhlu.+s.uoG.ao-ppl.pp.lp..pp.Lp...sht...........hppt.sh...................................t..........tssha..l................................cPph....VhElpa.s.ph.stu...........................G...slRa.Pp.ah...+lRpDK..............................	0	429	801	1111
+213	PF04675	DNA_ligase_A_N		DNA ligase N terminus	Kerrison ND	anon	DOMO:DM04655;	Family	This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1).  It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I (Swiss:P18858), and in Saccharomyces cerevisiae (Swiss:P04819), this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus (Swiss:P16272) this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation [1].	21.40	21.40	21.40	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.99	0.71	-4.46	154	1767	2009-01-15 18:05:59	2003-04-07 12:59:11	9	63	1048	8	992	1785	366	162.80	20	23.21	CHANGED	h.atpls.chhppl....pp.....souRhph.................sphlsshh...cp...h.ttp................lssslalhhspl.hPshp.sp.clGlup.phLh+.slupshs..hs.pplcp......thpp...........................hGDlu.sstphh......pppp.h.h...........psLTlp..c.VhppLpclAphsG..........ps......SppcKhphlppLhsps..ss.................tEt+allRhlhscLRlG.luctslhsAlup	........................................................h.ths.phhptl.........pt..................sstp.th.........................hp.hltphh.....pp...h.t.t........................hh.shhhhht.h.l.hs..........ht..t.................h...hsl.tp.p....h.lhc.hhsp..hhs......hs.....tthct..................phtt..........................................................hG..Dlu.tshtthh..............................pppp..h..................ssLTlp....p.V.ptLpplup...h.st......................................t..........spppph.p.h.......ltpl....hp.ps..ss.......................pEt+all.Rh.l.t.t.............c.l.R..l.G.hupphlhpAlu...........................................	1	319	572	820
+214	PF00875	DNA_photolyase		DNA photolyase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_777 (release 3.0)	Domain	This domain binds a light harvesting cofactor.	24.70	24.70	24.80	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.76	0.71	-4.50	143	3841	2012-10-02 18:00:56	2003-04-07 12:59:11	13	21	2592	52	1233	3283	3027	163.30	23	33.49	CHANGED	slhWFR.cDLRlpDNsALh....tA......hps...s..t.......llsla..lh-sp.........................ussptt..aLhcuLpsLpppL....pphG...spLhlhpG.s.......stphls....pl.sp........phs.sssVahscchpshtpppDpplpptLp.p.........slph..ppapsp.hLhp...Ptpl.......s...psu.psacVFTPFh+thhp....ph.............shss..Pp	.................................lhWFR.cD.LRlpDN.ALt.....................tA............hps.....s..st................................l.ls.la..lhsPp..........t.t.......................................ustphp...alhpsLpsLppsL....tp.h...s..............hs..L...hlhp.u.s.................................shphl.....pl...sp....................................ph.....s.....ss.....pl.....a.hs.tp.h.........p.s...p.p.pR.D..p..t.l..p..p...t..hp..p.................t..s..l.th..pth.p.s.p...hlht...s.tpl...h............s......tps..p.aplFosF.hpthhp.hh.................h.h....................................................................	0	406	772	1048
+215	PF00136	DNA_pol_B		DNA polymerase family B	Sonnhammer ELL	anon	Prosite	Family	This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.64	0.70	-5.71	67	6234	2012-10-02 01:06:00	2003-04-07 12:59:11	16	79	2425	290	1405	5186	2614	299.90	23	42.52	CHANGED	Gpph+lhshLLctstpcshllPspppt......................................................................pptsYpGAhVl-Php.Ghapsslh....llDFuSLYPSIIhsaN.....LCaoTllts......................................................................................................thsphp.p........chhp..hh..t....hhsp..splppulLspLLcphlp......hR+th+pthtpsps.hp............phlhDtpQhAlKlssNSsYGhhGsssu.hL.shslAtolTshGRphlppTpchlcph.........h...................................shcVlYGDTDSlalphss.sh......................ptshphucchsptlsppl........hhpslcLEhEKsaptllLls.KK+YhGlhh..........t..sch.hKGl-hVR+sssphspphhppllchlhpcpsssps.......httlp............hhhchlps.......................htp.h.tttl..slsphlhoptLo..+shssYpspp...........Hlplst+htpcs...........tphPtluDRlsYVllps......................................................tptsh.hchAccsp.ah............l.lDscaYls.plhtslpplhpslhhs.................sshtpsphltthh.pp	.................................................................................................................................................................................................................................................................................h.s.h.V....hp.s.......s.h.....a...t......l......hhDatuLYP.SIh.shp.............l.s.sshh..........................................................................................................................................................................................................................................................................................................................p..h.s...l...l...sth...ltphht.........................................hRpt.h.+...p......h.tt...t..............................hhs...Q....Ah.....KlhhNuh.YGhhG.s.t............t.u.....h.h...s.h...lA.s.slThhG......R.phlppscph.lct....................................................................................................................th.p.lhY..GDTDSh.hl....h.......................................................................t....t..h.t.t.h...ht...p.........................................t......phch-..th....a...........hhh.......................t....K.........K........p...Yh.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.........................................................................................................................................................................	0	474	778	1158
+216	PF03104	DNA_pol_B_exo1	DNA_pol_B_exo;	DNA polymerase family B, exonuclease domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	This domain has 3' to 5' exonuclease activity and adopts a ribonuclease H type fold.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.10	0.70	-5.57	32	3652	2012-10-03 01:22:09	2003-04-07 12:59:11	14	66	1910	166	1392	3971	1871	275.30	17	26.07	CHANGED	hsp-stsshhpshshpsYFYhts.cspp..phtp......................................hhcthpsthhplchlp+.............psh.h.ts......hh+l.hss...h......plpp.h..............sthpha................................EhslshhtRahlDp.slhshsWhplpts............................ht.sphch.h.hpsl.sh.tpt......sthplhuFDIEshtttt....FP..-sppD.lltIShhh.t.s.......................hssshpphhaoltsps...............................sstlh.a..ssEhclLptahphlpphcP-llsuYNhssFDhsYlhsRsptl.......hshthp.htph..tth..............................ppppphphsGtlthDhathhpcch........phsSYpLssV	......................................................................................................................................................................h...........................................................................................................................................................................................................................................................................................................hhtl.hhtt..t.h....................tht..p...ltt.........................................thhp.ha..................................................................................................Es.sl..................+ahh-p....t....lh.....s.......s.W.h..php.t.................................................................................p...h...h.........t...p.h.....s.h...t.................................sshp.h....h.uh..DI.E.s.ttp.t..........................t...p...lh.t..I..u..........................................................httshtp.hh.h.h.l..t.s.p.s............................................................................................................shpl.....h......ssE....hpl.Lp.........thh.........t..hh....t....p...h..........c...P...D....l....l.h..GaN......l..p..FDh.h.lhpR..........s.p...t.h...........................h.t..h.t..........t..........ph.....tt.t..t..h.......................................................p.t..thh.p.htGplhhDhh.p.hhppth.........phtoapLpsl..................................................................................................	0	451	750	1140
+217	PF04081	DNA_pol_delta_4		DNA polymerase delta, subunit 4 	Wood V, Finn RD	anon	Pfam-B_25322 (release 7.3);	Family	\N	25.00	25.00	27.80	27.60	24.50	24.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.68	0.71	-3.85	3	194	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	154	0	132	178	1	116.20	30	71.61	CHANGED	sG+KssI+DVaPVVVRcEusQuHp.K...uEpuP..............h+p-.ELu.tlEEP.......WNQIcuERhuEsl...HsEslTclEhlLRaFDlou+YGPClGITRLQRWpRAKphGLNPP.EVhpVLhL+EGDsEsRh+ESLaH	.....................................................................................................tt.tt.................................................................................................................................................................pt..sthE.clLRpFDls.pYGPClGloRLcRWcRAppLGLs.PP.EVhslL.tcps.c................................	0	38	71	100
+218	PF00772	DnaB		DnaB-like helicase N terminal domain	Bateman A	anon	Pfam-B_1000 (release 2.1)	Domain	The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.18	0.72	-4.15	156	5852	2009-01-15 18:05:59	2003-04-07 12:59:11	16	42	4498	45	1143	3975	2460	101.40	33	21.41	CHANGED	t.Pps...h.-AEpulLGulLh..s..sc..shsplhshL.p...s-cFapttHphIFcshhcLhpps...pslDhloltppL.....cppsplcp.h.uGhsYLspLspssso...ss.slptYAc.llp-	................................Ppsl.-AEpuVLGulhl......c......s-..th.s...p.l...t..-..h..l...p....scDFYpts.HchIF.pshhcLhpps........csl.Dh.lT.l...tppL.........pp..ps.p.L.c.p....l....G.....G...hsYL.....s.cL....s.ps.s.Po....uA...NlphYAc.IVp-.............................................................	1	376	752	973
+219	PF03796	DnaB_C		DnaB-like helicase C terminal domain	Bateman A, Eberhardt R	anon	Pfam-B_1000 (release 2.1)	Domain	The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null --hand HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.57	0.70	-5.50	36	6233	2012-10-05 12:31:07	2003-04-07 12:59:11	10	50	4730	57	1194	6420	5596	259.00	43	57.26	CHANGED	GlsTGah-LDphos..Ghppu-LIIlAARPuMGKTAFAlslApslAhcp..............p.tsVulFSLEMuscQLshRhluspupl.......ssppLRs.Gpls..cc-ap+lspshspLscts.laIDDosslolsplRu+sRRL+pp..tslslllIDYLQLhpust...ts-s.....RppElopISRuLKsLA+ELslPVlALSQLSRslEpRs.DKRPhLSDLRESG.............................................................................................................................................................................................................................................................................................................................................................................................................................................uIEQD.....ADlVhFlaR--hYpp................cspttt..................................hsElI.........luKp..RsGssG.............oVp.....LtFpspas+Fssltt	...................................................................................................................................................................................................................................................................................GlsTG.ap-L.D.c.........h.T..u..G...h....p.t.u-.L.....IIlA........ARPuM..GKT.sFA....lNlups.s.A...h....p.p......................p....tsVs.lF..SLE.....M.u.u...c.......Q.....l...s...h....R......h.........l...u.....u.....t......u.pl.........................st.p+..l.....R......s......G......p......L...s.............-...-...-...............W............t.....+...l......s...t....s...h....s.......p......L........p....c...t........s......l.a..I..D......D.....o...s...u........l...o....h...s..-....l..R.........u.+....s....R....R....l....t..............p...................c....................t.........s.......l.s......lI.lID.Y....L....Q....L....h.p.uss.............ts-s...........Rp...pE.l.uE...I.S...RsLK.s...LA..K....EL...plPVlALS....QLs.R..u...l.............E....p......R...............s................D.......K....R.....P....h...h.........S......D..LRE..S...G..............................................................................................................................................................................................................................................................................................................................................................................................................................................u...I.E..Q.D.....ADllh...F.lY....R....-....-..h..Y.p..p...............p...s...p.t..ps........................................................hsElI...luKpR.N.G.s.h.G.....o.Vc...LtF.tpas+Fssh..t.........................................................................................................................	0	402	793	1014
+220	PF00226	DnaJ		DnaJ domain	Birney E, Finn RD	anon	Prosite	Domain	DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction.  DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.02	0.72	-4.23	257	27964	2012-10-01 22:35:57	2003-04-07 12:59:11	26	628	5589	64	12023	23598	6923	62.00	36	16.78	CHANGED	-aYclLGlsp.........sAopp-IK+AYR+LAhpaHPD+Ntsss.......................ApccFcclscAYclLoDsp+.RptYD	............................................shYplL..Glsp.............................sA..s.....t...p.-....I....K.........+...A...YR...+L..u..h........c...a.....H.....P..D+sssss...........................................................Apc+.....F.p..........c.....l.......s....c.....AY..-........l.........L.s.D.pp...Rt.YD....................................................................	0	4164	7147	9951
+221	PF03351	DOMON		DOMON domain	Aravind L, Coggill P	anon	Aravind L	Domain	The DOMON (named after dopamine beta-monooxygenase N-terminal) domain is 110-125 residues long. It is predicted to form an all beta fold with up to 11 strands and is secreted to the extracellular compartment. The beta-strand folding produces a hydrophobic pocket which appears to bind soluble haem. This is consistent with the predominant architectures where the protein is associated with cytochromes or enzymatic domains whose activity involves redox or electron transfer reactions potentially as a direct participant in the electron transfer process. The DOMON domain superfamily, of which this is just one member, shows (1) multiple hydrophobic residues that contribute to the hydrophobic core of the strands of the beta-sandwich, and small residues found at the boundaries of strands and loops, (2) a strongly conserved charged residue (usually arginine/lysine) at the end of strand 9, which possibly stabilises the loop between 9 and 10, and (3) a polar residue (usually histidine, lysine or arginine), that interacts or coordinates with ligands [1]. The suggested superfamily includes both haem- and sugar-binding members: the haem-binding families being the ethyl-Benzoate dehydrogenase family EB_dh, Pfam:PF09459, the cellobiose dehydrogenase family CBDH and this family, and the sugar-binding families being the xylanases, CBM_4_9, Pfam:PF02018. The common feature of the superfamily is the 11-beta-strand structure, although the first and eleventh strands are not well conserved either within families or between families.	25.40	25.40	25.50	25.50	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.66	0.71	-4.19	83	1117	2009-09-13 17:03:55	2003-04-07 12:59:11	12	71	205	0	875	1100	7	114.80	18	23.84	CHANGED	ps..sphplpWphs.tspplphplp..sp.....ssasulGFSs...pst.MsssDhllshsp.s...upsplpDta..........sssts.sphD...p.....pshphhs...st.psshhphpFpRplso.....s-s.pDhtl.tsssh.plla.AhG	............................................t...th.ltaph.....t.....s.p...t.l.phplp........sp........ssaluhGhSs............stt..M.......s.su.D.hhlshhs.s........sps..h.lp-ha....................sssp..s....sphD....t..............psh.ph..hp.................s.t.....p...s.s..h..h.hhpF.p.....R.lts.........s-s..t-h.l.....stsh..hllhu......................................................................	0	378	488	741
+222	PF04124	Dor1		Dor1-like family 	Wood V, Finn RD	anon	Pfam-B_12640 (release 7.3);	Family	Dor1 is involved in vesicle targeting to the yeast Golgi  apparatus and complexes with a number of other trafficking proteins, which include Sec34 and Sec35 [1].	19.80	19.80	19.80	19.90	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.94	0.70	-5.98	7	407	2012-10-03 17:31:52	2003-04-07 12:59:11	7	12	287	0	282	582	28	253.10	23	60.75	CHANGED	lpcLsspsl-pLc+...c.ttLsp-ttpl.tphpsLuhsNY+shlcsAcsppshhpphss.ctphssLhppl......................scLpptspcF.ppupplsEp.....p+hsphhhpppsplh-lLElPpLMs............................pClcpu..haccAL-LpuaspRLppphsp...PllpslssplcpshtphLspLlppLcss.lpLspsl+llsYLR+h.sshscsp.LRhpFLps..p-thLps....hlp.ls.sss..hlpphIphhRsphachlhQYhulFs..-ssh........h.sp.shssstlhs.ashsphoshhphlEthl.+t...lus.lcplhhphhhht.uFthsstDhcuhhs.hhpphlhpphppslppsh-	..............................................................................................................................h.p.......lt.p.tth..phptls....tpht.hlts...tpt....th..t..h...t.h....ttp.htt.l.....t.t.l.....................................................................thtt.......t.h....th....p.t..t.p......pp.........................p.p.s....hhpp.pp..l...-....lL-.lPpLhp....................................tshpt..s.............app.u.l.p..l..ta.hp.p.L...tp.............hh........s....p..............s......lhp..........tl.....tps.t..t...h.t.hh.t.p.Llt...L.p.t......lpL....stsl..+.hlsaLR+.h....s................h............p................t................p....hp...........hhtt......ptthhtt............................................................t.s..........hl...p+hlph...hR.phas....hls.Ypsl...Fs....pt....................................t.........th...........s.tlhp...a.....p.ht.h.h...ph.lct..L.ph............t.thpplh.phhhhs.uhshhshDht..h...............................................................................................................................................	0	96	157	238
+223	PF04173	DoxD		TQO small subunit DoxD	Kletzin A, Studholme DJ	anon	[2]	Family	Swiss:P97207 is a subunit of the terminal quinol oxidase present in the plasma  membrane of Acidianus ambivalens, with calculated molecular mass of 20.4 kDa [1]. Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation.  A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Swiss:Q8AAF0.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.96	0.71	-4.57	7	130	2012-10-02 13:32:46	2003-04-07 12:59:11	8	6	104	0	41	859	161	154.60	30	51.50	CHANGED	ah..lRlslGhhahsAhlR+tlLpPuKLsPsSouYVGtKhlpFLPpu.ushKshL.hll.s.sLLhshLlhFohlEhlhGLhhllGhhTRLsulsshshuhGhhLuAhWLGoTC.DEWQIuhLhsuuuhhlhhoGutph.ulDhlLh+Khpp...t.hlhlhp.........al.Lh	................................................................h.lRhshGahahsuhhR+h...l....h...t....s.....KLsP.s.u....stalG.Kh..p......aLP.pu.....hs.......h.....+....s........hl.thll.s.sl....L..a.......th.h....l..lF.oh...l...Eh.lhG.Lh.lllGlhTR....L...s...u.......l.......s...s........h...h....L....u....h....s.......l...h........L........u........u........u.....W..h..G.s.......T...C...h.....D.......E....W.......p....l.....u......h...l..h.....h.....u.su....h.sl..h..h..s..G...uGt.a...SlDhh.lh.p+ht......................hhhh............................................	0	17	29	37
+224	PF00930	DPPIV_N	DPPIV_N_term; 	Dipeptidyl peptidase IV (DPP IV) N-terminal region	Finn RD, Bateman A	anon	Pfam-B_1017 (release 3.0)	Family	This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.13	0.70	-5.86	43	2539	2012-10-05 17:30:42	2003-04-07 12:59:11	16	64	1098	252	1068	2839	947	293.20	19	41.08	CHANGED	SsDtphlLlths........hpp.aRaShpusaalaDlps...........tphppLsss...........t.lphspaSPs..GptluaVhsNNlYlp...phsss..pthplTs..DG.....psslh.....NGlsDWVYEEE.huspsuhWWSPDup..........tlAahchs-otVshhphshassptt..........YPcshph+...YPKAGssN.spVpLhlhsl...psspsh......pltsss..tsp..DhYlspVsW..ssc.....sc..lhlphhsRtQsthplhhs...-h............ts.spsshhp.......p-ssssWl....chpptshhh.........pssspalhhsp.+sG....apHLhhassssp.....................t...tlTpGsW-V....hp.lhuhDtppshlYFtusc..cs....Ptp+plYplshp.......ssph..ppLosstspp........sssFSss.spaalhsapuPssPh	..................................................................................................................................................................................................................th...sst...s..........p........l........s....ah..................p......t......s.....l....ah......................t..tt..........t.htlT..........su...........hh...........................G....s.....t...h.....hh......p...............-..E..........h......t......................u.......h.....h...Wussup...................................hlhh.hphs.p..s.l..h..h....................................................t..th.........Y.Ph..........sG...t.....s....s.hp....l.hh.h.ph.........tt.t............................................h.....................t.............h...l......s..t...htW......ss......................tp..hh.h.hhsR....p..p...lhhh.....s................................................................................tp...tt.....hh.............................ppp.st..tal.........p....t.t.hhh....................................................sspph..hhh.p....+s....G.......ap....HLahhshsstt..................................................................hp.....tlT.....p.G.p.apV..........................tp...hht...hs...pp...pp....h...la...Fhusp.....pp............sh..p.....p.....p...lYp.l.shs................................ssth....ppl.o..s.p.t..spp..............................s.ss.hSs......s.....t.p.....ahl...hp.s.t....................................................................................................................................................................	0	360	605	877
+225	PF05186	Dpy-30		Dpy-30 motif	Wood V, Bateman A	anon	Pfam-B_13490 (release 7.7)	Motif	This motif is found in a wide variety of domain contexts. It is found in the Dpy-30 proteins hence the motifs name. It is about 40 residues long and is probably formed of two alpha-helices. It may be a dimerisation motif analogous to Pfam:PF02197 (Bateman A pers obs).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.99	0.72	-4.47	14	749	2012-10-01 20:11:07	2003-04-07 12:59:11	8	40	244	4	498	708	14	41.20	37	11.81	CHANGED	ss+pYLspsVsPhLlpGLstlA+pRPpDPlpaLApaLh+pps	..................h+pYL.p.p.p.Vs.PsLhpGLs.pls......+..p........+P...s......DPl...c.aLApaLhcpp.......	0	197	267	394
+226	PF01414	DSL		Delta serrate ligand	Ponting CP, Schultz J, Bork P	anon	SMART	Domain	\N	28.90	28.90	29.50	28.90	28.40	28.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.66	0.72	-3.97	18	522	2012-10-03 09:47:55	2003-04-07 12:59:11	14	157	113	2	298	473	0	61.00	42	8.53	CHANGED	Wppshasusps....clcYphRssCD-pYYGpuCspFCRPRDDtFGHaoCsppGpKhC.sGWpGp.C	..................Wpt...tsths.....plcaphRlhC.c-pYYGp..sCspaC.+P....R.D.D.h.FG.HYsCs.p.s.Gs+..sChsGWpG..C...........	0	117	141	227
+227	PF01666	DX		DX module	Hutter H, Bateman A	anon	[1]	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 6 conserved cysteines that probably form three disulphide bridges.	25.00	25.00	25.70	25.70	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.98	0.72	-3.54	5	33	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	5	0	33	30	0	78.20	28	17.46	CHANGED	PYhTppKCospcsIPhc.t.auFCDsDTGRluILGchpl......cGs-Np-sc.RYCooN+DCoso....oVCVh........hssssupCascP	.......YpTshsCssspslstsap.auFCcs-Tp+lhllGphsh......sGpch...pchp..ppCshNpDC...up.s....pV.CVh...........s.ppthCa.sP.............................	0	7	12	33
+228	PF00782	DSPc		Dual specificity phosphatase, catalytic domain	SMART	anon	Alignment kindly provided by SMART	Domain	Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.73	0.71	-4.57	24	6758	2012-10-02 20:12:17	2003-04-07 12:59:11	15	122	1439	108	3888	7101	596	125.70	20	31.76	CHANGED	lYLuutssst....shhpthslshllNlstths................sphphhplP.lpD..........ppssplstahspshpFIc.ps...ppputpVLVHCtAGlSRSAolslAYLMpppsh.shs-Ahphl......+p+R.stlsPNhsFhtQLhpacpp	................................................................................................................................................tt...tlph...l.l..s.hs.....t..................................................t.t....h....p.h..h.p.l...h.D.............................................................tt....sh.......t..h....h......p...p....s....h..p..h...lc....ps...................pp..p...s........s........p.........V....l..V..H.........C....t....s...G........l.uRS........us..........l.........l....h.....A.....Y.....L....h.......p............p......t.............t.............h....s.............h...........p..-.A.h..p.h.l.....................+pp.R....s...h..h.........s.....s...ahttL......t..................................................	0	1325	2005	2947
+229	PF00035	dsrm		Double-stranded RNA binding motif	Eddy SR	anon	Published_alignment	Domain	Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.	23.00	21.00	23.00	21.00	22.90	20.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-9.21	0.72	-3.39	110	8915	2012-10-02 17:51:51	2003-04-07 12:59:11	20	142	4747	68	3095	7369	1675	65.70	27	21.06	CHANGED	sts...hLpc.hspptt......hthththhtppssspt...tFts...plpl........ss.pths....pGtu.......p.sK.KpAcppAAppuLppL	...............................................KotLpE.hhp.t.pt.....................hshtap.h.lp.ppGs....s+p....p..pFss..............plpl.......................ss..pp..hs.........pGpG.............p.SK.KpAc......ppAAppALp..............	0	830	1497	2299
+230	PF01951	Archease	DUF101; 	Archease protein family (MTH1598/TM1083)	Enright A, Ouzounis C, Bateman A, Anantharaman V	anon	Enright A	Domain	This archease family of proteins [1], has two SHS2 domains [2], with one inserted into another. It is predicted to be an enzyme [2]. It is predicted to act as a chaperone in DNA/RNA metabolism [1]. 	25.00	25.00	41.10	41.10	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.78	0.71	-4.22	96	503	2012-10-02 11:08:51	2003-04-07 12:59:11	11	6	472	2	280	485	93	134.80	29	85.80	CHANGED	acal-H..TADltlcuhGsoLcEsFpsAuhAhhslhs.-hsplc...........sc.cp...hclplp.upDh-sLLacaLsELlahhcsc.thlhpc...hclp.hs..........................................thplcupshGEphc.p+Ht..hts-lKAlTYathc............................lpp.psst..........................apspsllDl	..............achl-H..TADlt.lcuaGsol-EsFppuuhuhhshhs...D.hsplc...........st..pp.....hplchp....ucDh-sLLacaLsEllahhss.c...thlh.pc....hclp..hc.............................................thplcupshGEphsht..+H....t..sElKAlTYpthp............................lpp..ppst..............................acstlllDl......................................	0	104	172	233
+231	PF02575	YbaB_DNA_bd	DUF149;	YbaB/EbfC DNA-binding family	Mian N, Bateman A, Eberhardt R	anon	COG0718	Family	This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure [1-3]. The conformation of the DNA is changed when bound to these proteins [3]. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage [1].	25.20	25.20	25.20	25.30	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.97	0.72	-4.10	139	4505	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	4084	9	1047	2557	1477	92.10	35	83.07	CHANGED	hcQApp.hQpp....hpchQccLsphplpGpuGuG....hVpVphsGctclhslpIcspll.c......-DhEhLpDLlhuAhN-Ahp+scphtpp...chsphou.Gh..shP	..................................MKQAQp.MQcc....MpchQc-L....up...hclsGpuGuG....lVpVoh....s....G....ppplpclcIcssll...-...............-DhEhLpDLlhuAhN-Ahp+s-ctppc...chuphou.Gh.t.........................	0	372	713	898
+232	PF02580	Tyr_Deacylase	DUF154;	D-Tyr-tRNA(Tyr) deacylase	Mian N, Bateman A, Moxon SJ	anon	COG1490	Family	This family comprises of several D-Tyr-tRNA(Tyr) deacylase proteins. Cell growth inhibition by several d-amino acids can be explained by an in vivo  production of d-aminoacyl-tRNA molecules. Escherichia coli and yeast cells express an enzyme, d-Tyr-tRNA(Tyr) deacylase, capable of recycling such d-aminoacyl-tRNA molecules into free tRNA and d-amino acid. Accordingly, upon inactivation of the genes of the above deacylases, the toxicity of d-amino acids increases. Orthologues of the deacylase are found in many cells [1].	25.00	25.00	25.50	25.50	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.71	0.71	-4.21	37	3993	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	3782	94	988	2599	777	142.60	45	94.69	CHANGED	+sVlQRVppApVsV....-sc........llGpI....spGlllLlGltcs.....Dop-chchhscKllslRlF.....-D-psK.hNhSlpDls.GplLlVSQFTLhu-spKGpRPsFppuuss-pAptLY-pFsphl+pts..............................pVcsGpFGAcMpVpLsNDGPVTlll-s	.........................................+sllQRVppAsVs..V..........................-uc............lsGp.I.........spG....LllLlGlpps.....................Ds....c.....p.....cs.....c.....hl...........scKlhshRlF......................pD..-...p....G..........K.....MNhSl.p-l.............s.....Gp.....lL...l................VSQ..FTLhADT.+K.Gp.R.PuFsp.....AAs....P-tAptLY-hFs.p.p.h+ppt...h............................pVpTGpFGAcM.pVs.LlNDGPVTlhL-............................................	0	335	604	813
+233	PF02583	Trns_repr_metal	DUF156;	Metal-sensitive transcriptional repressor	Mian N, Bateman A, Eberhardt R	anon	COG1937	Family	This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [1-5].	21.20	21.20	21.30	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.84	0.72	-3.79	147	4323	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	2741	7	851	2245	340	83.60	30	88.61	CHANGED	tpp+ccll.pRL+RIc...GQlcGl.p+Ml.Ep...cc..Ch-lLpQluAl+uAls....pltthllcsHlcpClt.pshps.......tppp...ptlcElhphlp+h	...........p+ppll...sRL+RIcGQlcul.p+Ml.Ec.....c.c...Ct-lLpQluAl+uAls....slhtt..llcpHlp.cCls..pshpp.........tppc...pplc-hhphlpp..............................	0	298	568	728
+234	PF02588	DUF161		Uncharacterized BCR, YitT family COG1284	Mian N, Bateman A	anon	Yeats C	Family	This is probably a bacterial ABC transporter permease (personal obs:Yeats C).	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.64	0.72	-3.68	189	12563	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	2439	0	2056	8039	1861	84.60	21	58.10	CHANGED	phlhhlhGuhlhuhGhshhhtss.hssGGhssluhllp.phhs...................lshuhhhhlls.lslhlhuhhh...................................h............ph.........................................................slhollshhlhuhhl	.....................hlhhlhGuh.lh.ulG.l.s.hh.htss.h..ssGG...hssl.uhllp..p..hhs...........................l.s.h.uhhh..hh...lN.hsllll.uhhh.........................................................................h............sh.................................................................................slhollshhlhuhh......................................................................................	0	729	1389	1730
+235	PF02639	DUF188		Uncharacterized BCR, YaiI/YqxD family COG1671	Mian N, Bateman A	anon	COG1671	Family	\N	24.30	24.30	24.30	24.70	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.41	0.71	-4.70	167	2006	2012-10-03 20:43:45	2003-04-07 12:59:11	9	4	1980	0	382	1203	282	129.60	39	85.25	CHANGED	hlh+sApRtpl.lhlVANphlphPs...............p.shlctlhVssGhDsADshIscpspsGDlVlTuDIPLAucllpKGuhslsP+GchaopcNItptLshRchMpclRsu..Gh.......o.GGPssauppDRppFtssLD+hlt+	...............................lh+sAcRhp.l.lslVANps..h.t.s.ss.............................p..phlcslhV.ss.GhDsADpcIVppscsG..D.....l..VITtDIPLAutllcKGu.hsLsP+GchYosssIcptLshRshhsplRtu.....Gh....p....TuGP.sshopcDRptFtspL-+hl................	0	115	236	310
+236	PF02641	DUF190		Uncharacterized ACR, COG1993	Mian N, Bateman A	anon	COG1993	Family	\N	20.50	20.50	20.50	20.50	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.33	0.72	-4.14	5	725	2012-10-01 21:59:08	2003-04-07 12:59:11	10	8	534	4	284	539	18	99.30	27	76.82	CHANGED	lKpKLLRIYouEs-+aEGcPhYKsllc+L+E.cGIcGATVaRGIsG.YGK++clHuc-lFpLSscLPVllElVDccEsIpRsLccl+EhhKs.GLITlEcVcVh	.............................t....hLplahuEp...c+......h..p..u.cP.la.c.tllchh+c.tul.A.G.AT.VhRGltG..aGp..pp.h.l.Hs..schh.pL...u..p...c.lP.l.slphVDstcclpthls.p.l.p.phh....pp....u...LlTh-.s...h...................................	0	107	189	248
+237	PF02958	EcKinase	DUF227;	Ecdysteroid kinase	Bateman A, Eberhardt R	anon	Pfam-B_2081 (release 6.4)	Family	This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-12.02	0.70	-5.27	54	1726	2012-10-02 22:05:25	2003-04-07 12:59:11	15	28	286	0	1069	4192	1235	241.30	19	65.13	CHANGED	pG-NYsShhhRlplch.........p.spsppp.......hohllKs............h..tpstttphhp.phtlFppEhshYppllPchcplh.cps.............s..hphhscshhhp.....tp.p....phllhEDLs.pGapsssR.hpsLsh-cschslcKLApaHAsShshtp...p.s..htph...pGhhppthhps......pshh...pshhpshhchh.pphsththht.....p+lpplts..phhcphhphhp..........sssspasVLsHGDhWsNNlMFcYcsps...p.p-shhlDFQhspauSPuhDLhYhlhoSsp.-h.+hpph-pllphYappLhc.pLctLsa	.............................................................................................................................................................thhs.hhph.h.h..................t...t.t.....p..................hshhlKh.........................................tp.......hht....t....t..h..a....t..p..Eh.....hY..pp..hhP..thtth.tt.............................h..hspshhsp.................................t............hll..h.EDL....p..........t....u...a..p......h.s.c...ht.s.h......s......hpc....h.ph.slppLAphHAhoh...shtp..........p..........................t......h........s...h.h....t..t........h.....t..t..........................t.....h..h........t..th..h.p..t..hh.p...h.h.......t..t...........t.h.........................................tth.p.t..h....t......p.h..h...p....h..h.p.hht................tttth....p...s...l....s.....HGDha..............hs..Nhha.......p.......h.........s......tt......t........................................p...........s............h...hlD...........a....Q..hsthu....s....s....shD....l....h...a....h...l...h......s...s...h....p......ph.....p...............pp...h....pt..h.l...phYaptLhp.lt.....................................................	1	287	431	878
+238	PF02995	DUF229		Protein of unknown function (DUF229)	Bateman A	anon	Pfam-B_1566 (release 6.4)	Family	Members of this family are uncharacterised.  They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.73	0.70	-6.08	17	540	2012-10-03 20:55:17	2003-04-07 12:59:11	12	17	54	0	424	1427	722	390.00	22	71.40	CHANGED	c.hphppCspsp.hhspphs.phpphhlphpt.....hh.....tshpChY.pphtRtpst...pshhhh.phhth...hppsh.l.ss...................................s-hhpspChp.shsphh.............pDshtalpp.....ph..p.............ptpss.ptcc.SVhllGlDSlS+hphhRphP+shpalp.phsahEh.GYNKVGDNohPNLlslLoG...........hsp.thptsp....psttshDphsaIWKpFppt.GYtThauEDt..sshssFsY.....p.GFpcpPsDaYhRPhhhthEpphphhtp.ths....ChGp+.tpphlh-ahtpFh.+apsph....hFuahWssphoH-.hphssth.................DcthhpaLpphccpuhh-solllhhSDHG...........................................................hRaGphcpsh....pGhhEERhPhhhlhhPpah+..cpaPphhpNLphNpc+LoosaDlHtTLccllpLsshsctphps...t.ps.............+shSLFhPlPpp.RoCtpAsI.p+aCsCpshpplssss.....hhpphuptlVpplNchlts.........pthCpsLpLpplp	..........................................................................................................................................t.................................................................h.C.h.....h.h.........................................................t.....................................................................phh.h.C......t.............................hh..............................................t...sVhhhslDShSphp.hh.R...............p..hPcshp........al........p...p...............................s........h......h.ph..uaN...p........l.u..-soh..sNhhslhsG............................stt.th.t.h.......t.t.hDth.s.hla.ppapp.......t.GYh....Th....a....uED..............ths.h.ap..................h.GF...p..P.s.....D..aYh.....R.sh....h....h....t..hp..p......ht..............th...................C.h.s.tc..hphhh-..a.h....t............phh.tt.a....pp..................hFuh....h..a.....s...p...h....sH....s...h.p.hh.thh.............................................................Dpt...hh.phl.pp.h.pp..p.t..................................hpp..ohllhhuDH.G.......................................................................................................................................................hR......a..u.......t..h.t...p.t.................pG..h.h...E..c....p.....Ph...hh.l...hlP.hh+..............pp..h.sphhp...sLp.Npp+Ls...............os...a.Dl+tT.L.......hcll.p.htt.....t......................t.......................................ps.S.Lh....l.P.p..RsCt.ps.s..I.....p.aChC......ht..t.h....p.p............................h.thuphh...lt.......hNphh.t....................Ct.hplt...h.........................................................................................................................................................................................................................	0	173	212	373
+239	PF01697	Glyco_transf_92	DUF23;	Glycosyltransferase family 92	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1694 (release 4.1)	Domain	Members of this family act as galactosyltransferases, belonging to glycosyltransferase family 92 [1,2]. The aligned region contains several conserved cysteine residues and several charged residues that may be catalytic residues. This is supported by the inclusion of this family in the GT-A glycosyl transferase superfamily.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.81	0.70	-5.10	52	812	2012-10-03 05:28:31	2003-04-07 12:59:11	22	17	132	0	706	894	66	240.60	15	52.56	CHANGED	+slslCluPlass-s....phhpalphh+lt..Gus+hhlYhts.hspphhpllcpY.pct...Gh.lplp.a..................................hp.ptph.h+spthuhsDChlp..h+ttscahuhhDlD-hlhsps..phh.....pphpphhpshts.phhthphpstthhp..tp.hssh...sh..h............................t..................................KsllcPpplsthhhHhshph.t.....................s.thhplpp..h.....cs.p.............................................................................hhpht...phhtch.hpphhhshhhpshppphht	.....................................................................hhhCh.t.shhht....t....plhpalth.hphh................Gs..s+h.hh.Y....ts......h...sp.p..h..hc..l..lc....Y..pt...........G.h..l..p..l...h..sh................................................................t.p..t.th..h..hts..phhsh...sDCl..h+................p.............t......p...s.......c........ahshhDlDEhl....h..s....hp..........................p..h...t....ph.h.p...p...h...t...............t...........h........t...t......h...t........hpphhh....t..........t...t..hs..th............t....t...h...p.h.hh.th........t..t...............................................................K.hlhps.....ptl.....t..h.h.h.H..h.....sh.phh................................t.h..h..........h...Hhp...................................................................................................................................................hh..........................................................................................................................................................................................	1	240	340	659
+241	PF02996	Prefoldin	DUF232;	Prefoldin subunit	Bateman A, Moxon SJ	anon	Pfam-B_1664 (release 6.4)	Family	This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT [1].	23.20	23.20	23.20	24.00	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.16	0.71	-4.46	37	1254	2012-10-02 17:27:01	2003-04-07 12:59:11	12	25	488	2	812	1220	90	116.60	19	50.84	CHANGED	hcttlpplpsphsplppthsclcpshpslcslpp........spshchhlslusslahpupl..cssc.....lllplGsshhlEhshc-Ahchlcc+lpplpcphcplppplpplppphsphttphpphtpp	...................................................p...tphppphpplptthsc....hppsh.cslpplpp..........................tppsh.c...hhl.sl.s......ss..h.a......sp.............upl..ss..s..sc............................Vhlt...lG..ss..hhlEhshc-Ahphlcc+.....lptlp.pplcp....lp....pplpt....h....ppphp...hht...htph.........................................................	0	274	444	656
+244	PF03080	DUF239	DUF239; Glucoamylase;	Domain of unknown function (DUF239)	Griffiths-Jones SR	anon	Pfam-B_913 (release 6.4)	Family	This is a family of plant and bacterial proteins, a small number of which are putative carboxy-terminal peptidases (see for example Swiss:Q9XIN9).	22.00	21.50	22.40	21.90	21.70	21.30	hmmbuild  --amino -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.71	0.70	-5.28	54	602	2009-01-15 18:05:59	2003-04-07 12:59:11	10	22	47	0	366	574	2	189.70	33	56.66	CHANGED	aaGspAslsVasPpltp..t..paShuplal.sGs..stp...hssIpAGWtVpPplaGDspsRhasaW...cshpts.GCYNhhCs...GFV.Qsspp.lslGsslpssSs.hsst.p.htlphhlh+...D.psGNWWLp..h.ts........hlGYWPupLFsp..lsst.AshlpaGGpVhsst......st..pssP.MGSG+.Fstp.s..htcAuahpslp.llDtss...phhss......psh..hssp.p.CYslpsht.......................hGth..haYG...GP	.............................................hhGspuslslap.Pplpt...s...phShuplalhsGs...ttp..............hss.IpsGWp..............V.........PphY...s...Ds..ts+hahaW....o.............t............-............sh....pts....GC.a....Nh...Cs....GFl.Qs..s.pp..hshGss.lt...shSs....hsut.p....htlplhlap.................D.tpGsWWlt....h.sst......hlG.....YWPttLFs..........lt.p....t....As.hlpaGGplhssp.....s..sss...MGSGp....astp...s...htpuuahpslp.hhstst...phhs.........h...hsppsp.CYslt.h...................t..t.h.hhaGGP.................................................	0	63	183	236
+245	PF03087	DUF241		Arabidopsis protein of unknown function	Griffiths-Jones SR	anon	Pfam-B_1563 (release 6.5)	Family	This family represents a number of Arabidopsis proteins. Their functions are unknown.	23.10	23.10	23.20	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.62	0.70	-4.87	11	556	2012-10-01 23:20:42	2003-04-07 12:59:11	9	4	17	0	392	492	0	161.50	25	80.30	CHANGED	huLusLpELYcslpchLchssoppthtppp....hhEchLDuSlclLDlCussRDlhspl+EplpsLQSuLRR+c..ut.....lcsclcuYls.RKpl+KEhpKhltuLKphpst.............t...ptsslsslhcpshtholslh+olhphLSs.....scs.h.hpstLhshhhhppstt.pstt...............hcsEhpplDtthpt....sppphhcclcphEhs...........lc-lEcpLEuLa+pLIpsRVSLLNI	..............................................................t.....h.tlh.thtphh.hs...st.....................h-t.h-t.l.llDhpsh.hp-.h.th+t.htphp.sl++tc.....................tspl.t..t.hht......h.+ph.p...Ktht+..h.tthtt.t.............................................hhthhtps...hsh....shh.pshh..hlst...................th.h.hsphh........p.t...................................................................................................................................................ppl.p.tlc.s...............................................ltthEttht.laRpLlpsRs...slLN.......................................................................................	0	16	176	308
+246	PF03103	DUF243		Domain of unknown function (DUF243)	Bateman A	anon	Pfam-B_1157 (release 6.5)	Family	This family of uncharacterised proteins is only found in fly proteins. It is found associated with YLP motifs Pfam:PF02757 in some proteins.	25.00	25.00	51.50	46.00	19.40	23.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.57	0.72	-3.87	31	401	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	29	0	246	417	0	96.70	39	34.43	CHANGED	llpKchYlHssP.--.E-......tptth.susspKpY+llFIKAPss..ssspAslthspstsEEKTllYVLsKKs-ttp.sttls.s.tsspsuKPEVaFIKY	.........lpKcFYsasAP.E-s.-p.....ts......tphh....susspKsh+VlFIKuPps..sh.psA.s.lthsp.tssEp+TsIYVLsKps-.sshsp.pls...s.psspssKPEVaFlKY.............	0	45	60	165
+247	PF03140	DUF247		Plant protein of unknown function	Mifsud W	anon	Pfam-B_1292 (release 6.5)	Family	The function of the plant proteins constituting this family is unknown.	24.80	24.80	24.90	25.50	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.35	0.70	-5.46	48	1014	2009-01-15 18:05:59	2003-04-07 12:59:11	10	19	25	0	634	924	0	301.50	22	82.37	CHANGED	IaRVPtpl+.ch..sp.cuY.pPplVSlGPY.H+u..pppL................psMEpaKhRhLpphls+ss.............tslpphlsslpslEpcs.Rss....Ys-sss................hssc-...FlcMllLDGCFlLchhhthsp......................stsDs.lashphhhsh...l..ppDhlLLENQlPaFVLccLhphhp.................................ttpspssLsplshp....ah.............t.shthss......thhtptps............pHlLcLh+pshl......ss.tp......tsttshpp.t...........................................phlhsAs-LcpsGV+F..+ppcs.............sp........................hhD.lpF..c....pG.s......LclPplhlc-sTpplhtNLlAFEQs.psss...............sshlTuYlhFMssLlsoscDVslL.pccGllcshlGs-.....p-Vuc.hFsp.Lscs......ss.hs.hcs...salss....lhpplspappp....php.....phhApl++.paFssPWshhuh...lAAlllllhT	.........................................................................................................h...h.........p....t.a..PthlulG..P.h...+tt......t.th...........................h-phKhhhhtthhtt.t.......................htthht...ht..t........ph..+t.............Ytt...............................ht.tpp.....hh.hhhhDus...Fll.hh....h.................................................................................t..................h...............l.....DhhhlENQlP....hhl.l.pt.lhth.........................................................................h....thhht......hh...................................................................................Hhh.chhh...hh..............................................................................................................................................................h.s.stpLt.t.sG.lph...t.ttt.........................................................................hhs..lph...p............tu..h....................lp..lP.l.....l.pt..st.hhhNhhAhEtt..t...........................t..hssY...h.hhs.l.lss..pDlthL..hpptl.l......p.h...h...t......s.p............pt.ssp..hhpt.lspt.............................hh..hs..............hh.t.........hht.tlpt....ah.pp.........h.............................hhh.t...hh......a...h...s...h.hhs..hhshhhh..........................................................	0	33	377	521
+248	PF03141	Methyltransf_29	DUF248;	Putative S-adenosyl-L-methionine-dependent methyltransferase	Mifsud W, Moxon SJ, Eberhardt R	anon	Pfam-B_1462 (release 6.5)	Family	This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [1,2].	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.73	0.70	-6.17	22	712	2012-10-10 17:06:42	2003-04-07 12:59:11	11	15	46	0	435	2409	358	380.90	35	73.10	CHANGED	-YhPChDsppshph....spcphpapERHCPs..........pcphpCLlPsP.cGYKsPlpWPcSRDhlWasNlPHs+...LsppKusQNWlphpG-hhpFPGGGTpF.pGAspYI-pluphls.......hsuplRssLDlGC.GVASFGAaLLs+sllTMShAP...+DsHEuQlQFALERGlPAhluVh...uTpRLPaPSpuFDhsHCSRChIsWppp-GhhLhElsRlLRPGGYalhSusPlh.........+pcp-.ppthcchpslscplCWchlsccsp......hsIWpKPhss.sChtp.Rpt..spPslCc.sc-sDssWYsphcsClo.hP-s.......ptsustlp.WPpRLpssPsRlps.....h.t.sh-tFcpDschWpcpVstYhclhp.hlppsclRNVMDMsAshGGFAAALtch...lWVMNVVPs.....ssssTLslIY-RGLlGsYHDWCEuFSTYPRTYDLlHAssLFShhp......pR.Csh.psILLEMDRILRPpGtlIIRDph-llscVcc.lspuh+Wcsphp-p...ccss....pEplLhspK	.................................................................................................hhPC.s.......t.......ht.h..hERpCP..............t...Clls.P..sYt..............Ph.WPtS.......+.......c.h...hhtNh..sa.t...ls....p..t.ppW....h....ptp..hh.....F.P.u.u...u.o.....F...t..G.s..........t..Y...l....p.................l......t.p......hhs...........................st..th...R...s.....sLDh...GC...G...................V....A.......S....a....G...u..h...L....h.....p.....c......s....l...l..s....h...S..h......AP........p..D..t....H....p....s....Q....l......Q......F....A......L......E....R.....G.......l....P......A....h....l...u......s..h.......u..o..p....+.....L.P.a.P.u.p.s...FD..hs......H..C..u..R..C..h...l.....s.....W...t....t......................s....G..h...........h...L.h.Els.RlLRPGG...a..a..l...ho...u...s..h...............................t...........t..t.....pt..h....t.h.....s.pt....hC...Wphh....p..tp......hslapK..sp..pCh......pt........hCp..t.p.ss..s.t...sW......................h.hpsCht..s.............t....aPtRh...s....hltt........t...t.p.att.Dpph.....Wpphltthh.h...........l.........t.......sp...............hRNlhDMpAhhGGFAAA.L..h..p........lW.VMNVVP...................tt.sTLslIa-RGLl......G....hhp........DW...CEuFsT.YPRTY.DLlHAstl..hoh.h...p......p+....Cp.h...lhlEhDRILRPtGh.hllRDp.thl.plpt...hhtthpWp...s...h..h.....t......p................hh.............................................................................................................................	0	54	278	354
+249	PF03164	Mon1	DUF254; 	Trafficking protein Mon1	Bateman A, Wood V	anon	Edwards YJK	Family	Members of this family have been called SAND proteins [4] although these proteins do not contain a SAND domain.  In Saccharomyces cerevisiae a protein complex of Mon1 and Ccz1 functions with the small GTPase Ypt7 to mediate vesicle trafficking to the vacuole [7]. The Mon1/Ccz1 complex is conserved in eukaryotic evolution and members of this family (previously known as DUF254) are distant homologues to domains of known structure that assemble into cargo vesicle adapter (AP) complexes [5]. [3] describes orthologues in Fugu rubripes.	20.40	20.40	20.50	21.20	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.53	0.70	-5.87	7	443	2009-09-11 23:32:11	2003-04-07 12:59:11	9	13	291	0	297	444	4	359.80	32	71.63	CHANGED	s.hsEthptpcKplFlLSEAGKPIaopa.Gs--tlsShhGlhpAlVSahpsst...sslpShpupup+lsFLp+SPLlLVusScospS.stpLhppLthlYtQIlShLTtsplp+lFpp+.pNaDLRRLLuGoEphhcsLl......pphsps..shLhsulpslPLssohR-tlossltp.......sphcsLlFulllAt.s+LlshVRhKchh....LHstDLpLlhsLlus..ps..csuEsWsPlCLP+FNssGFhaAalua.Lss....s.ssCLlLlSscR-sFFshpss+pclhp+Lcc.pthhpsLtcshpp........staplpplG..hPpL+HFLYKs.......KpssQassPthchshpstpEpp.......RL.ulYppLHs+l+p......sRshphhhchsp+-s.................................LhAWVTssF-LYhhhs.PlsoKshslpsVpKLl+Wl+KEEsRLFIhsshoa	..........................................................................t......hptppKHhalLSpA.GKPla........o.pa....G...........s.p....p.....hl.................s.shh....Glhpsl..l....S......ah.p.s..st.......................stlp...sh.......p..u..ss......h...+hV.al..p.cuPLhLVul..............S....p...........h..........t..........po..................t.p...........Lp.....tpL.ph...lahQIlShLThsplp+lFpp+..saDLR.+hLt.Go...-thh.ssLl..................................pthsps....s...s....hl..hs.ul.ps..l...Lt..t.s...hRptlsshl...p.................................spstsllaullhst..spllsl.lp.....+.p..h........................L+PsDLpLlhshl.s.............pt..s....h.........p..............s..u...........EsWhPlCLPp.FNssGahasalsa..lp.......................................thsl....lLlSs..p..+....-..s..F.at....lpp.....h+...ppl........pt...lpp.tsshtt.....lt..puh.pt..........................................hp...h..t...l.s........hs...l.pHFl..YKs........+t.s....Qa..s.....sph......psshtp...t..ppp.................................+.Lhth..Ypp...La........s...ph+s..........................................t.t..h.......+..hhhh.....h..s...ppts..................................................................hhsWh............Ts.FEL..Y......hsh.s.....s.......s.s+.s......hhts.hpclhpWhpppcp.clFl.........................................................................................................	0	103	166	245
+250	PF03194	LUC7	DUF259; 	LUC7 N_terminus	Mifsud W	anon	Pfam-B_2902 (release 6.5)	Family	This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein [1] with a role in splice site recognition [2]. The family also contains human and mouse LUC7 like (LUC7L) proteins [3] and human cisplatin resistance-associated overexpressed protein (CROP) [4].	33.00	33.00	33.50	34.40	32.30	32.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.90	0.70	-4.85	8	689	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	292	0	416	616	10	242.10	34	76.98	CHANGED	sDphRphLDQLMG...osRsscpp+st..l+asDccVC+uaLlshCPHDlFssT+hD.LGsCsKlH-.ph+t-YEpAs+pccah..aEh-hhchlpp.........................hlsDsD++lchu+pRLccspE-pss.sss.p..scpltslscc...........................IschLscsEsLGccGcV--u.clhcclEcL+sc+pcltc..................................................ps+sssPusu.h....................................spQKL+VCElCGAaLultDsDcRLADHFsGKhHLGYsplR-pltELccstsc.........+pc-Rcc+t......hsspRph	.......................................t....tthL-pLMG...........tt.p....s.....h..s.pctp...........lpa.s.D.cV............C+.aLhshCPH-l..hs..sT............+....D......LG................C..............K.l.H...s...........t.....L+tpY....E...t...us...c.p...t....ch.........h.....aEh-...hhchLpp.........................hls-s-R+lchuccRL.....tpop...........cc.....h....s...s...t....s....s...s.p.......tcclppLscc................................Isp.hL.......tc.sE.pL.Gt...pGpV--up.ph.hpclE...pl+tc+cchcp...............................................................................................................................h....p..s.....t.h..s.....s...........................................................................................tppKLcVC-VCuAa..Lul..tDs..-..pRl....s..DHhhGKhHlGahpl..RcplpcLpcphtp......................................ppptptt..............................................................................................................................................	0	139	215	329
+251	PF01657	Stress-antifung	DUF26;	Salt stress response/antifungal	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_980 (release 4.1)	Family	This domain is often found in association with the kinase domains Pfam:PF00069 or Pfam:PF07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges [1]. It has a role in salt stress response [2] and has antifungal activity [3].	25.00	25.00	25.20	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-11.24	0.72	-3.70	175	2349	2009-01-15 18:05:59	2003-04-07 12:59:11	12	43	34	4	1517	2447	0	101.20	22	40.19	CHANGED	hphC.....sssth.s.....sss.a.ppslpsllssLss..p.ust..............hassu.......s.......sss....pVYuls.Cps.D.l....s....s....ss..CpsC.lspuhppht....p.C......st....ppsuhlh.....hss.ChlRYs.ts.F	..................................................t...............t........sss.a..ppslp...pl.hs.s..Lss.pssss.....................ttFsssp..................s...st..sss........plYu.lspC.....p..s..D....l.....s......s.....ss....Cp..sC.lss.uhs.pl.......ph.......C.............ss.....pps..u...tlh........hsp...ChlRYp......................................	0	213	869	1163
+252	PF03195	DUF260		Protein of unknown function DUF260	Mifsud W	anon	Pfam-B_2998 (release 6.5)	Family	\N	21.50	21.50	22.10	24.70	21.00	19.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.22	0.72	-3.73	46	709	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	35	0	506	727	0	98.50	43	47.36	CHANGED	sCAACKaLRR.+Csss.ClhAPYF.....Ps..sp.s...ppFtslH+lFGsuNlsKhLppl..sspp.R.....scuhsSlhYEApuRhpDPVhGssGhlhpLppplpphps.-lshspppl	...............................sCuACKhLRR.+Csps.ClhAPYF................Ps......sp..s...p+FsslHKlFGASNlsKhLp....cl.............P..pp..R.....s-AssSlsYEA...........puRl+DPVY.GCVGhI.tLQpplpplps-Lshhpt..h............................................	0	69	316	409
+254	PF03268	DUF267		Caenorhabditis protein of unknown function, DUF267	Mifsud W	anon	Pfam-B_4201 (release 6.5)	Family	\N	25.00	25.00	48.50	36.40	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.07	0.70	-5.60	7	50	2012-10-01 21:54:26	2003-04-07 12:59:11	9	2	6	0	49	42	0	323.90	31	88.29	CHANGED	lLGsa+allKhosLDCSppu........+lpulhsplhslshlshhhhRhhhhhph-upsLohuWAEsNhFuFhulpuhshulsLauWTKsuhlspahp+LtclR.LRlpsNpc.hDpYtph+hchFlaSh.allshhupAIashlp.pKIhhussshs.shhhhh.hh..hhshahshlpLshahLlphulsREhcaFNpELEcAppsKpLpsssllpcFsaRQtcllchlp.sscpLpsasussPLFhahuLhNulalho...hhs.lsslYhIhlhh.LhulIhhshhhLhPAuhVQ-plhpTo+ILMssp-FcpSKDspVYpTYRhMlDRSh+spophhVlsuhsIs.pshphAhFlIPNls	.................................................lhG.achhh+hohLDC.shhs........phpthhstlhulhllhhhhh+.hhhh.hth..pup.LShsWAEushauFhuhpuhhsuhslhsWTppshl.pa.cpLsplRhLRlpss.pp.hDsYptl+h+Ahlhsh..hhsshhupu....lashhp.p+lhhu......sspss....hhahhhshlshlshah..sslsLshYhLlpsulsRElcaFNcELccApccKpL.................ps.slLpcFshRQt-llchlphsNcpLssasshuPhFhhh......uhlNusYlso...F.hsslPslahlhLhh.lhuslhhshhhLhPsutlQcplppTucILhsscphcpspDsplapTYRlMlDRs.+scopltVlsuFslsppshstAhFhlPNls........	0	15	20	49
+255	PF03269	DUF268		Caenorhabditis protein of unknown function, DUF268	Mifsud W	anon	Pfam-B_4252 (release 6.5)	Family	\N	21.10	21.10	22.00	27.00	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.14	0.71	-4.69	6	72	2012-10-10 17:06:42	2003-04-07 12:59:11	9	5	28	0	60	76	45	152.30	40	44.35	CHANGED	DGhSGVVlGShpPWVEVpALppG.......sspILTVEYNs..LsIpEcF+-R..lSSIhPhDFspNacpYusoFDFAASFSSIEHsGLGRYGDPlDPIGDLREMLKIKCsLK.GGLLFLGlPlGpDAl.aNsHRIYGslRLAMMhhGFEWIsTFSG-oEpuhDLoupcL+ccsLFuhsQpTLVLRKL	........................................................pshlhuS...PhhEh.ul.pG..............AtplLolp.s...lph....psp..hooh...-Fspp..a.p.pastp.FDFsuohooIEHsGLGRYGDPlD.PhGDl+thhcl+ClLKpGG................LLFLulPlG.s.DultaNAHRIYGslR.LsMhh.Ga-hlsoaut.ppp...ph..................................................................	0	18	24	60
+256	PF03312	DUF272		Protein of unknown function (DUF272)	Mifsud W, Pollington J	anon	Pfam-B_3609 (release 6.5)	Family	This family of proteins is restricted to C.elegans and has no known function. The protein contains a ubiquitin fold. The GO annotation for the protein indicates that it has a function in nematode larval development.	25.00	25.00	25.10	27.90	23.50	24.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.81	0.71	-3.91	15	49	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	5	0	48	51	0	125.30	30	28.11	CHANGED	FLWlsDpppcolh.pospasLphGHFF-GhFpcpssG.p..WpChcYl+pIctll.cGtlsss......KlplpsslppapPtsssp+.aPpsaucalGhllDsc...sKLstsCs.G+pVplptp+ls...tcpasWhVocll	............................aLWlhDpppculh....ho..........p....papLthGHFFEGhFpcptsu..+............WpC...p.....cYh+tl.pt..L..l..cGslsts......+I.lplplpp.a.pPs.sss.pc.aspshucalGcll...-tp..................s+Ls.tsss.G+...plplphtp...lt...ppsahWhVscl..................................................	0	14	16	48
+257	PF03409	Glycoprotein	DUF274; Glycoprotein_Ce;	Transmembrane glycoprotein	Finn RD, Pollington J	anon	Pfam-B_4416 (release 6.6)	Family	This family of proteins has some GO annotations for positive regulation of growth rate and nematode larval development. This is probably a family of membrane glycoproteins [1].	19.50	19.50	19.50	21.00	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.11	0.70	-5.71	17	125	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	5	0	124	122	0	283.90	24	79.27	CHANGED	s-sshplYl.AuuDcsphLppI...hlTssspshoLspLpss...pssG.hpsas..lsssshloTo.sssshtsLsGhIYloospQtpDss.FtVYslpss.pslshs....sspoTllhLNT.h........stPhtoShlophsQsssoslhhYtGhPtDshpphs......sphFsNPhhhps.........tsphFFssVEshpl.uLssaYl+ohs.slsFhlcstahs...hsshsTTus.sTTGhhMp..spssssh.sVNhtpDss.hs.GsSGs.lsutls..tusloVsh.ssssshppshsssp.hs..saphshhu.pshplsST..sshsGpaYlQYFshpGs..s...oooshssp.sssp..........................................................lpTTTKuusslplhhShhlhhhh.h	...................................................................................sshplYl.ApsDs..sthLppI...hhsssst.ph...........oL.pLtt.....ps.sG...p.sh...lp..s.shhlsos.sss.hptLsGhlYloo.tQhp.....ss................s.F.Vhslptt.p.lpht.......psThlhLNoth...........P...sohlophtQs.ss..h.ha.uhPtst.p..t......p.hFpNPh.h............................haFsplE.hpl.sh.haYhps..s.shph.lpstahs...................ps.hs..Touh.sTTGhhhp..s....pph.slphhp.....D.p.....hsGhsGh.l..........s...h....splsh.....t..s.....t....t..sh...tt.........h.h.h.s.pp..hplps.s..s...s.G.aah.....QYahhps............ss.s..s..............................................................................ooTt......................hh.....................................................................................................................................................................................................................................	0	26	36	124
+258	PF03357	Snf7	DUF279; SNF7; ESCRT-III; 	Snf7	Mifsud W, Moxon SJ, Mistry J, Wood V	anon	Pfam-B_1641 (release 6.6)	Family	This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localisation, requires the formation of multivesicular bodies (MVBs).  These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins [1]. A few archaeal sequences are also present within this family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.96	0.71	-4.87	34	2816	2012-10-03 05:15:35	2003-04-07 12:59:11	16	31	380	24	1871	2693	44	169.10	19	70.47	CHANGED	cshhpLccshctlc+cpcplEpplcc.ctpl....+chtpp.....ts...........KctAhhhLKc++phEpplsphtsphssl-phthslcshpssppshsuMptuscshKsh..ppphcl-clcclM--hp-ph-htcpIpEslucshs.....sshDE--lptEL-pLtpE.h.pp...................sspLPssPossh	.......................................pLcpshc..pLp+p...t...p.........pl..cpp.cp....p..tpl.........+ch..h.pp......sp..............................pptA.hh....h.h+pthp....h.c.pp.hpphh..........stts.p....l.ct.hthplp.................st.ps...........ppps...hpu.hpt....uscs....hc.ph...pp..p.h..s......l.p..........c......lpplh..c-h.p.c...p..h.ph....h....s............l..p-....h..l..ss...s....h.s...............sp.h-.....E........-...E....l......-...t...E..l.p......p..l.h..pE...ht.p.................................t.ph.s.ths....h.........................................................................	1	636	1020	1514
+259	PF03380	DUF282		Caenorhabditis protein of unknown function, DUF282	Mifsud W	anon	Pfam-B_2840 (release 6.6)	Family	\N	22.80	21.80	22.80	21.80	20.30	18.00	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.08	0.72	-4.21	29	67	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	7	0	65	80	0	37.50	43	23.36	CHANGED	PCosCsK.IYDssCQGhGlPShtsaCssAu-VslsYolGs	.......sCssCsp.lY-s..sCpGhGlPshhsaCsTAuElslpYolG......	0	23	24	65
+260	PF03368	Dicer_dimer	DUF283; dsRNA_bind;	Dicer dimerisation domain	Bateman A, Mistry J, Eberhardt R	anon	Bateman A	Domain	This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules.  It is essential for the activity of Dicer [1,2]. It is a divergent double stranded RNA-binding domain [3]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [4]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [4].	22.60	22.60	23.10	22.70	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.00	0.72	-4.21	29	491	2009-01-15 18:05:59	2003-04-07 12:59:11	9	58	217	1	308	546	1	94.40	28	5.81	CHANGED	AlshLt+YCupLPpDsasphpPpaphtpts.s...........thhs.plhLP..lsusl+p.lhGp.shpsp+hAKpsAAapACptLachG.LsD+LlPl..hccphtt	.............................................ulshlp+YCupL........P.s..D.t...........a....s.p.h.p..P.paphpphp..s.............................................thhs.plhLP.....hsuP..l...+p...lhG....shs........spchA+psAAhpACppL+ch...G...tLs.D.pLhPh..hpc...t..........	0	93	165	251
+261	PF03382	DUF285		Mycoplasma protein of unknown function, DUF285	Mifsud W	anon	Pfam-B_2864 (release 6.6)	Family	This region appears distantly related to leucine rich repeats.	25.00	10.00	25.20	10.00	24.70	9.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.06	0.71	-11.96	0.71	-4.54	147	2904	2012-10-02 21:32:02	2003-04-07 12:59:11	9	141	295	0	944	3084	4291	103.50	29	50.46	CHANGED	oshpthF..tss...p.......ph........s.psl.......ssWD.....TSsVTsMssMFtsAp...sF..Nps.I....u........s.W.sTSsV........ssM.stMF....tsAps..............F.NQ...sl....us............WssSsVpsMppMFps...AssF.Nps...l....u..sW..ss.usV.pshp.....tMFtsu..ps...Fsps.l......s.sW	......................................................................................................................................................................................................sl........spa..s......s.S.pV.....s.s..M.pt........M......F..t........s......s.....p..........s.h.........s.ts....l......u................s.W..s.s...S..s...V..............ssM..s..tMF..........ts.s...p.s...................Fsp......sl....us.............................W..s.....s..S..p.V.........s.....s......M.p..tM.Fts............sp.sa...s..ts..........l....s...pW..sh.....pp..h.........t.....h.................................................................................................................	0	393	623	794
+262	PF01060	DUF290	Worm_family_2; 	Transthyretin-like family	Bateman A	anon	[1]	Family	This family called family 2 in [1], has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones.\	     The specific function of this protein is unknown.	24.90	24.90	24.90	25.20	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.84	0.72	-3.97	60	474	2009-01-15 18:05:59	2003-04-07 12:59:11	18	15	21	0	419	374	1	79.90	33	48.62	CHANGED	+G+LhCsscP..spslp.V+La-c-.p........s.DchLspspT..cssGpFplpGspsEl....os.........I-P..hlpIaHcCsstsh.......Cp.+chplpIP	.................pGpLhCs.spP.....ss...slp.V+La-cD.p..........................s.D..-lls.p.shT....cssGpFplpG.s..p.sEh.......ss..................I-P....hlpIaHcCsstsh................Cp.+phph.lP...............................	0	150	203	419
+263	PF03478	DUF295		Protein of unknown function (DUF295)	Bateman A	anon	Pfam-B_790 (release 7.0)	Family	This family of proteins are found in plants.  The function of the proteins is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.81	0.72	-4.60	168	1123	2009-09-11 23:18:59	2003-04-07 12:59:11	13	33	21	0	656	979	2	57.40	22	14.95	CHANGED	hhclp..sl....Gc.cslFl.up.spshsss..s...pp...............u.lc.sNslY.....Fs....cs.............................shsl..asl	................hhclp..sL....G.s.csl.....Fl....Gp..s......p.uhs.hs....u.....pp......hs.......u..lc..ssslY...Fh.....cs......................................h....................................................	0	78	186	369
+264	PF03556	Cullin_binding	DUF298;	Cullin binding	Finn RD, Mistry J, Wood V, Eberhardt R	anon	Pfam-B_3021 (release 7.0)	Family	This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation [1-3]. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices [1,2].	27.90	27.90	28.80	28.30	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.92	0.71	-3.95	46	733	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	292	14	456	685	5	115.20	37	44.82	CHANGED	lpcl+pplsplcp.....cL..........ptDspt............F+clYcaoFsaup...cps.....Q+sLsl-hAlshWpLlh..........................ssp.h..............shlctWhcFL.ppp...............pc+u....................Is+DoWshhLpFspph...p.tshosYD.--uAWPsllD-FVEahc	................................................................................pclpspl.spLcppL......................p...-.ssp...........F+chYpasFsau+.....pts.......Q+uL..cl-hAlshWpLlL............................stp..a..........shlshWhpFL.ppp...........................ph+s...........................Is+DpWs.lL-Fsppl.......s..s-hSNYD..-...-...........G.A.WPsLlD-FVEah..............................	0	137	223	342
+265	PF03619	Solute_trans_a	DUF300;	Organic solute transporter Ostalpha	Finn RD, Eberhardt R	anon	Pfam-B_3382 (release 7.0)	Family	This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters [1]. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death [2].	20.70	20.70	20.80	21.10	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.75	0.70	-5.08	55	925	2009-01-15 18:05:59	2003-04-07 12:59:11	11	17	295	0	664	890	27	242.80	29	59.14	CHANGED	sphshh..luuhhslhAhhlShatIhpHLhpYppPppQRhllR.........ILhMVPlYAlsSaluLlh.ptu.........hah-slR-sYEAFlIYsFhsLLhsaLGG....Ep....slhthhp.t+.shp........ashPl.................t.hh.cs.............................hhs.pahphsKtGlLQY...........................sllKPlhsllsllhphhGhY.tpuphshstuahalsllhNhSlolALYsLslFYhshcc..-LpPacPlhKFLslKsllFhSFWQGlllulLsth..Gllpsttthtt..........plusulQshLlClEMhhhAlsHhaAFshpsY	.................................................................h.....hhush.hshhshhlohh.lh...HhhtYp...p...P......................Q.+..h..ll...R.........Ilhh.....lPlY.uh..Salu..Lhh..pts.............hahsslR-sYE..Aa.slY...sFhtLhhp.alGu..............cp...........sl.ht...hp...sc..hp................psh.sh....................................hhh...h....s...............................................................................................hhhs.....thht.......hhKhu.slQa...........................s.ll+Plh..sll..s..llhph.h...G...hY..p.........-...up......h......s....hp.t..ua...halsllhNlS..........h..sh.AL....YsLhlFa.hsh..+c.............Lp...s....h.p.P..l.hKFl.s..lK.h..l.lF..h...........oaW..Qu.hhl.u.lL.th.....Gh....l.sh...t................p..lssulps.h.llClEMhhhulhthauFshpsY.............................................	2	236	372	538
+266	PF03703	bPH_2	DUF304;	Bacterial PH domain	Yeats C, Bateman A	anon	Yeats C	Domain	Domain found in uncharacterised family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.37	0.72	-3.96	219	4794	2012-10-04 00:02:24	2003-04-07 12:59:11	9	20	1523	0	1147	3777	643	80.00	18	42.58	CHANGED	h+sht..apl..osc+.ltlpt.Ghhs..+cppplshsclpslph.p..l.RhhGh.uclslphssss....................plphhslspsccltphl	..........................h.hp...atl....pscp..lh..lpp..G.l.ht.......+c..p..thlshpR.lQslsh..pp.u.hltRhhGl..sslplpouuss...................................h.lsh.lsh.ppspplht..................................................	0	385	845	1038
+267	PF03713	DUF305		Domain of unknown function (DUF305)	Yeats C, Bateman A	anon	Yeats C	Domain	Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1.  This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important.  This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.20	0.71	-4.39	86	1321	2012-10-01 21:25:29	2003-04-07 12:59:11	8	8	713	3	551	1532	484	122.80	24	68.56	CHANGED	DhsFhppMlsHHpQAlcMuphsh...p+upssplcsLAppIhsuQpsEIspMpuWLptWstssssss................................................t.ttttttssMs.......GMhostphspLpsupG.............sshDphFLphMIsHHpGAlsMApstl.........p...pu.pssplp.plApsIlssQpsEIspMpphL	............................................................................a...h..ap..u.l.hs................t....th.ths.tl..tpt.pht.h..hh.................................................................................t....tth...............th..hpt........h.t...h.t.t.h..t........................sphDhhFhph.M.l.s.H.HpGAl.t..MA.p.h.t.l............p......u..ps.s.p...h.cplApp...llpsQptEIttMpth.............................................................................................................................	0	158	358	476
+268	PF03754	DUF313		Domain of unknown function (DUF313) 	Finn RD	anon	Pfam-B_2540 (release 7.0)	Family	Family of proteins from Arabidopsis thaliana with uncharacterised function.	24.40	24.40	24.40	24.50	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.27	0.71	-4.16	14	95	2012-10-02 12:51:43	2003-04-07 12:59:11	8	4	11	0	70	93	0	102.50	29	36.72	CHANGED	pphPcWLlpsM+chpG...pcP.+LIhcKs.LhpTDl.ssspuRL...uhPhspllpsDFLT.-EpRhl.......................c-ct.sscshGlsshLV-sctpcaslpLK+WsM......pushpYsLspGWNsVVcs	.................................P..lhphhpphpu...p-s..+hlhpKp.LhtoDl.ssspsRL....hPhp.plhp.p..-......FLTppEpchl..................................p.p.pt...t..pcthGltshlls........ph....pph.tlph++WpM........pts..YsL..psWp.pllp.s............	0	21	40	47
+269	PF03761	DUF316		Domain of unknown function (DUF316) 	Finn RD, Bateman A, Pollington J	anon	Pfam-B_2972 (release 7.0)	Family	This family of proteins with unknown function are from Caenorhabditis elegans. The protein has GO references indicating the protein is a positive regulator of growth rate and is also involved in nematode larval development.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.91	0.70	-5.06	9	172	2012-10-02 13:45:52	2003-04-07 12:59:11	10	6	7	0	171	227	0	232.30	16	67.50	CHANGED	hlhlhhhllhhshssspcLo.cENppRhpoCGpchls.ps...........ssshhsptpppsWhlhsthpstsptphh........suohISsRHllTsuplhhsscptW.h.....cpssspssCsus..pL.VP.-lLcclcl......sphpsppshptpls+AhlhshC......h..t.phttsPMllElcts.....sssshsCLuscspp.hccs-hlcsYGl......psstchhcpphslsss........s.hphsosthhsptctuGsLlpphss+hsllGhtussshtspt......sthFaslsp.hpppICchsGIC	............................................h.........................tpLs.pENt.h.tpCG.......................................................................................................ts..Whh..h...h..t...................................sushISsRHllsss..p...hh..h.......p.....t........p........t.....h....t......................t..h....t.p.Ct..t.t......h..........ls.p.p..h.h.p.p.h.h....................t................h....hp.hhhhthC......................................t....h....ll...Ehpps........................h.....t....sCl.s.......p.......p....................tp......h..p.hath......................tt...h......t...hph.t.h......................t.h.ht......t.t.....s......tp....Gus.hlt........h..s.sc...p..l.lGl...hs.tss..t..........................hah..p.hth.htpplCphsGlC....................................................................................................................................................................................................	0	23	38	171
+270	PF03777	DUF320		Small secreted domain (DUF320)  	Yeats C	anon	Yeats C	Domain	Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	20.20	20.20	22.10	20.50	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-8.88	0.72	-4.20	17	305	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	44	0	123	327	0	60.30	52	54.99	CHANGED	usuusAtu..susApGuAssSPGVlSGNsVQlPVHVPVNVCGNTVsVlGlLNPAhGNtCsNs	.................s..uuhAtu..suuA.pG.....s.As.u..SPG....VlSG..NsVQlPVcVPVNVCGNoVsVlGlLNPAaGNsCsN..............	0	47	99	123
+271	PF03860	DUF326		Domain of Unknown Function (DUF326) 	Yeats C	anon	Yeats C	Repeat	This family is a small cysteine-rich repeat. The cysteines mostly follow a C-X(2)-C-X(3)-C-X(2)-C-X(3) pattern,  though they often appear at other positions in the repeat as well.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.56	0.73	-7.95	0.73	-3.88	20	528	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	287	12	108	324	6	22.60	39	31.24	CHANGED	spchpppCt....chCpcCuctCppps	.....pchCphCA....chCppCA-tCtch.....	0	38	77	102
+272	PF03935	SKN1	DUF338; 	Beta-glucan synthesis-associated protein (SKN1)	Finn RD, Moxon SJ	anon	DOMO_DM01831	Family	This family consists of the beta-glucan synthesis-associated proteins KRE6 and SKN1. Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-glucan, and chitin. It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1. This is followed by maturation steps at the cell surface and by coupling to other cell wall macromolecules [1]. 	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.72	0.70	-6.35	26	512	2012-10-02 19:29:29	2003-04-07 12:59:11	10	17	128	0	415	1147	311	346.50	30	68.38	CHANGED	asLhh--cEsDDaLHNPDP..csph-+p+hhh-hchhs+RuhsslhGllhLhluhlslFlshPlLTao...sssp+tss..............pshphloshpYPhLuuIR.ouLlDPDTPpsAho+pup.c.GppWpLVFSDEFNs-GRTFY-GDDQFaTAsDlHYsATpDLEWYDPDAl.TTtNGTLplRhDAFpNHsLhYRSGMlQSWNKhCFT.tGhlElSAsLPshGsluGLWPGlWTMGNLGRPGYhAoTEGlWPYSY.-uCDsGITPNQSSsDG.....................ISYLPGQRLssCTC.sGEDHPsP.....G.sGRGAPEIDllEuphssshs.........lGsASQShQlAPFDIWYhPDY...salplYsposTshNoYsGGPFQQAlSulTsLNssWY..tt..su.ttFQpYuaEYh...N-ccsG.......YlsWaVGcpsTaTlhupALtPNG..NIutRhIScEPMSlIhNLGlSsNWAhIDWtpLh..FPssMpIDYVRlYQspsphs....VsCDPs-YPTh-YIppH.ssYpNsNLTsW....ppuGY..oaPKNpLhss.C	.......................................................................................................h....................................................................................................................................................................h...lD..pT...P......th.........h.......s......p.......s.........tth.L..............lhSDE..F.....p........................s.....R......o.......F..........h....G.....-..D.........h.a...p...u......c.....h.........................s.s...t..s....h.E.....h.....Y.............s............p...h...h.......s.T...............t................s.....G.......h............h..................h........p..................t..........................................................................t................t..................h..........................a.......puu................M................l...p............o.....W................N.................p.................hC..ap.....t........G..hl..Eh.............p.........hpL.........P..............s...................................s..t.......h...G....................h......WPuhW.h.G..N..Lu....Rs.h.a..uospt..h......WPaoY.ptC-.....shh...s.......................................................................+lstCss.....s....t.........t.s............uRuAPEIDhhEuth..................................hSpS..hQhu...P.............................................................................s.....p..h........s......................h........p..........p........uhSs.........ht.th.a..............................a.hathE......ah......................p.u..........lpW.h.tt...p.......a...p.....h..s..........t.u.....h......t.....s..ss..........p........s..........+.......h...........E.......P.......M...................hlhN..huh..S...sa...............t.....................................p...............l................hP....h.lDalRlYQ...........s...t...p.......lsCDP.s..a.P..T.p.aIt.t..a...t.Y..s..p.........................................................................................................................	0	198	310	400
+273	PF03990	DUF348		Domain of unknown function (DUF348)     	Yeats C	anon	Yeats C	Domain	This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593 (Swiss:P25357).  This protein is involved in sporulation part of the  SET3C complex, which is required to repress early/middle sporulation genes during meiosis ([2]). The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction  with the Pfam:PF07501 domain, which is involved in various cell surface processes.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.69	0.72	-4.38	167	1769	2009-01-15 18:05:59	2003-04-07 12:59:11	9	27	678	0	449	1328	21	42.70	28	24.80	CHANGED	sVslsl.-Gcpp.plh...TtusTVs-lL....pptsls.l........s.ppDplsPuhss	............Vslsl.sGcpp.plh...Tss.sTVs-hL......pptsls.l........s.spDtVsPuhs..................	0	167	335	408
+274	PF03993	DUF349		Domain of Unknown Function (DUF349)	Yeats C	anon	Yeats C	Domain	This domain is found singly or as up to five tandem repeats in a small set of  bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.	21.40	21.40	21.60	21.40	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.62	0.72	-3.82	128	2482	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	722	0	644	2200	886	77.50	24	48.45	CHANGED	-sLWpR.FcsApcta.cp+pthhpphcpppppNhptKctLlpcA.Eplts.ssc.....hpsstpph+pl.ccW+slG....plP.Rcps	.................................-tLWp+.Fpsspstahct+pt.th.......pptcppppp.shptKc....tLlpc....A.c.tLss..ssc................hpsstpph+pL.h....c....cW+.s.lG....tls.+c..............................	0	229	508	614
+275	PF04008	Adenosine_kin	DUF355; 	Adenosine specific kinase	Bateman A, Lott S, Mistry J	anon	COG1839	Family	The structure of a member of this family from the hyperthermophilic archaeon Pyrobaculum aerophilum contains a modified histidine residue which is interpreted as stable phosphorylation [1]. In vitro binding studies confirmed that adenosine and AMP but not ADP or ATP bind to the protein [1].	25.00	25.00	34.70	34.70	20.10	17.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.85	0.71	-4.72	34	283	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	277	26	124	228	14	154.30	59	95.54	CHANGED	Vsl-hP-.ssNlIlGQoHF.IKTVEDLaEsLlsoVPul+FGlAFsEASG.pLlRhsGND-cLhclAhcNAhtIuAGHsFllhl+su.aPINVLNslKsVsEVspIFsATANPlpVIVAcTc.pGRGllGVlDGhsPhGVEs-cDhpcR+chLRc.IGYKh	.....Vsl-pP-.ssNlIlGQoHF.IKTVEDLaEALVsssPul+FGlAFCEASG.RLVRaoGNDt-LlcLAscNAhsIGAGHsFlIaL+cG.aPI.NVLNslKsVPEVCpIaCATANPlpVlVApTs.pGRGllGVVDGhoPLGVEo-cDltpR+-LLRp.I.GYK.........................	0	45	78	104
+276	PF04013	Methyltrn_RNA_2	DUF358;	Putative SAM-dependent RNA methyltransferase	Bateman A, Eberhardt R	anon	COG1901	Family	This family is likely to be an S-adenosyl-L-methionine (SAM)-dependent RNA methyltransferase [1].	20.50	20.50	20.60	20.50	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.12	0.71	-4.77	7	215	2012-10-01 22:53:19	2003-04-07 12:59:11	7	2	203	7	89	165	66	185.90	39	94.48	CHANGED	MR.FllhuscAhTssshsLcDLPGsuGRlDllCRshssAhalSHuhRcsVplallLhGsPsPP+olphcusclc...hpPDEtslAhhlp+ALpuht....tttcph.pspPGlaVsphuFEsllptlhc..hslhhLcEcGtDIpssphs....NPsFllGDHlshsccphphL-ch...sh+lSlGPhsLhssHslsllpthLD+hth	...................................MRsFll+A+sAsTsup.h..Lc-lsG.pu+h-lLs+shhsulFhupuhRcDVhlaLVLpus.....D.s.+TIphcus.-lpp..sh.-pt.lAhll+th.tust......hsc-ph+.spPGl..pVcs.hoFEtLlt-lucc..t.......pLYhhcccGcsIR-hchss......NPsFlLoDHIshsccsts.lc+lG..scKI.SLGPchLaASpClsllHNElDpt......................	0	20	51	70
+277	PF04020	DUF360		Membrane protein of unknown function	Bateman A	anon	COG1950	Family	These proteins a predicted transmembrane proteins with probably four transmembrane spans. The function of these bacterial proteins is unknown. The sequences do not appear to contain any conserved polar residues that could form an active site.	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.72	0.72	-3.70	107	1355	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1191	0	468	1052	200	109.60	31	76.40	CHANGED	h...hphllphll.sAluLhlsuhlh..s........G...lplsu.....................hhsslluAlllGllNsll+PlLh.llolPlhl....lThG........LFsh.........VINAlhlhLs.uhll.s....G.....Fpl.pu.Fh.sAlluulllollshll	..............hphllphll....sulslhlluh..lh.s.........G.....lplsu.....................hhsAlluAlllullNsll+PlLh..ll....oLPlsl....lTL....G........LFt.h.........VlNAl.hlhls.uhlls...............uFpl....su.....Fh.sAlluulllSllshll..........	1	163	349	428
+278	PF04037	DUF382		Domain of unknown function (DUF382) 	Wood V, Finn RD, Moxon SJ, Sammut SJ	anon	Pfam-B_10232 (release 7.3);	Family	This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site [1].	21.90	21.90	22.30	24.60	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.57	0.71	-4.32	24	357	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	295	0	253	336	8	123.00	59	20.84	CHANGED	Vp+P-lVEhaDssupDPhhLltlKup+NsVPVPpHWspKRcYLpuKRGlEK.PFpLPcaIcpTGIschRssl.-c....-scpoLKQKpRERVpPKhG+lDIDYp+L+DAFF+aQo..KPc.LopaGDl......YYEGKEh	........Vt+P-VVEhaDsoApDP+LLVpLKuhRNoVPVPpHWshKRcYLp..............GKRG.IEKPPFpLPcFIpcTGItEMRp.........Al.EK............--ppoLKpK.RE+VpPKMGKlDIDYQKLHDAFFKaQT..KPc.LThaGDl......YYEGKE...........................	0	88	143	209
+279	PF04075	DUF385		Domain of unknown function (DUF385) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of Mycobacterium tuberculosis proteins.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.68	0.71	-4.19	10	1560	2012-10-02 11:35:36	2003-04-07 12:59:11	9	13	225	27	512	1351	399	123.90	24	82.54	CHANGED	s.hh.Rt.sthaRcssG.tlGpph...G.hP.hlLLpTsGR+oGpsR+TPL..htsccssp..ahlVAShGGss++PsWYhNl+AsPcVclplGscphssTA.R.ls..s--+Achathsstshsu.YssYQstTsRp.lP...VhVLps	.....................................................h.............h.t..s....h.u.t...h.............s...h.......s...hhl..LpssGR.KS.GpsRpoP..L.............hh.h..c.c.s.sp.........hhl.Vuo.t...Gu.....p...p....ss....WhpNlp.A.s..P.p...s..pl....p....h.....s.s.....c.....p.....h.s...s...s.A...c.ls..ss.-.+....s.phh..h..h.t.......s...s...h...h...t........s.t.....t..ls...hh..........................................	1	139	367	466
+280	PF04087	DUF389		Domain of unknown function (DUF389) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of hypothetical bacterial proteins with  an undetermined function.	22.60	22.60	22.90	22.70	21.90	22.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.89	0.71	-4.23	127	1004	2009-09-11 12:27:41	2003-04-07 12:59:11	9	4	851	0	318	852	168	140.40	38	35.44	CHANGED	MlIuPLhuPlhuhuhuhshsDhpLhp+ulhs.....lhlGhhlulhhuhlhu.hlhs.........l..p..hssElhuR..opPs....lhDlhlAlsuGsAGshuh.spp............h.usulsGVAIAsALlPPlsssGluluhu...................................p.hshuhGuhhLahsNl.luIslu	....................MLISPLMuPIlGluhululhDhcLl++Shps.....Lhltlhlullsuslah.hlsP......................ls....ssuElluR.........TsPs........lhDllIAlsuGlAGhluhppc.........ptssslsGVAIAsALhPPlsssGhulAtu....................................................s.hphhhGuhhLahlNsshIsls......................................	2	94	200	279
+281	PF04155	Ground-like	DUF398; 	Ground-like domain	Bateman A, Moxon SJ, Burglin TR	anon	Pfam-B_3296 (release 7.3)	Domain	This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides [1].  	35.40	35.40	35.70	36.60	31.30	35.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.44	0.72	-3.67	41	278	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	8	0	267	225	0	77.80	24	27.83	CHANGED	spsspCsstcLcplhpcshpt.........pshstspctlppsspppass..papVICupscFuasspss..paCph.ppsshsChsap	.................................ps.pCsstcLcplhppshp...........................sssppupctlppsscpphss...pFsVICupscFuahspss..taCph.ppsshsChsat...........	0	89	124	267
+282	PF04241	DUF423		Protein of unknown function (DUF423)	Kerrison ND, Finn RD, Pollington J	anon	COG2363	Family	This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.	25.00	25.00	25.90	25.60	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.16	0.72	-4.06	133	2074	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	1956	0	507	1237	289	88.50	40	68.64	CHANGED	ulGAFuAH...uL......c..sh.lsschhph.a.pTuspYphhHulALl.slu....hhht.......ssphhthuuhhhhhGllLFSGSLYhluLouh.....+hlGh.lTPlGGl	........................hLGAFGAH...sL..................p.....pp..lust.....t.h.sh...h.pTGlpYQhaHuLAlLslu....lhhtp...........huhhh.thu..uhhhhhGhlLFSGSLYsLuLotl.........+hhuh.lTPlGGl.............................	0	160	296	414
+284	PF04255	DUF433		Protein of unknown function (DUF433)	Kerrison ND	anon	COG2442	Family	\N	21.40	21.40	21.40	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.31	0.72	-4.55	140	905	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	315	2	319	945	159	53.80	31	47.88	CHANGED	Ish...sPslhuG+PsI+GTRlsVpsllphl.usGhoh-EILps..YPp.LstcDlhAALtYA	................IshsPphhtGpPsIcGpRlsV.tsllphl.ssGh.o.h--llpc..aPt.LshcslhsALtYh............	0	106	251	305
+285	PF01862	PvlArgDC	DUF44;	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	Methanococcus jannaschii contains homologues of most genes required for spermidine polyamine biosynthesis. Yet genomes from neither this organism nor any other euryarchaeon have orthologues of the pyridoxal 5'-phosphate- dependent ornithine or arginine decarboxylase genes, required to produce putrescine. Instead,these organisms have a new class of arginine decarboxylase (PvlArgDC) formed by the self-cleavage of a proenzyme into a 5-kDa subunit and a 12-kDa subunit that contains a reactive pyruvoyl group. Although this extremely thermostable enzyme has no significant sequence similarity to previously characterised proteins, conserved active site residues are similar to those of the pyruvoyl-dependent histidine decarboxylase enzyme, and its subunits form a similar (alpha-beta)(3) complex. Homologues of PvlArgDC are found in several bacterial genomes, including those of Chlamydia spp., which have no agmatine ureohydrolase enzyme to convert agmatine (decarboxylated arginine) into putrescine. In these intracellular pathogens, PvlArgDC may function analogously to pyruvoyl-dependent histidine decarboxylase; the cells are proposed to import arginine and export agmatine, increasing the pH and affecting the host cell's metabolism. Phylogenetic analysis of Pvl- ArgDC proteins suggests that this gene has been recruited from the euryarchaeal polyamine biosynthetic pathway to function as a degradative enzyme in bacteria [1].	21.00	21.00	21.70	23.30	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.93	0.71	-4.64	33	246	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	222	50	144	240	51	163.40	30	93.55	CHANGED	hlP++hFhTpGsGcpc.spLs.......uF-hALt-AGItphNLVpVSSIlPPps..chlscppuhthLsPGpllasVhu+..tsoscsschIuAulGhAhsp........pspaGhlsEacuhsppcc.utchucchApphhpsp....................utclhcsttlsppscl..p.ucasoslAAsValh	.........hPpphFhTtGsGcuc..stLs........uF-hALhcAsItshNLVplSSllPsps...pllshpps...c.hl..Gpll.slhAp..ssos.csschIuAulGluhsp.c.......ppthGhlsEapuhsp.s.pc..stchscchspthhppp....................shclt..-hphhspptpl..p.sthsTslussshh...............................................	0	48	93	125
+286	PF04332	DUF475		Protein of unknown function (DUF475)	Kerrison ND	anon	COG2899	Family	Predicted to be an integral membrane protein with multiple membrane spans.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.00	0.70	-4.84	7	451	2012-10-03 02:02:08	2003-04-07 12:59:11	10	2	409	0	130	677	107	296.80	50	83.95	CHANGED	FDNAllNAuIL+pMS.hWQKhFLTlGILIAVFGMRLlFPllIVuhoAtlsPlcshcLALps...........sspYpcllpsAHPpIAAFGGhFLLMlFLsFhhc-cc.h+WLphlE+PLs+lG+lshlssllshlhLllhuthhstsuc.ht........tVLhAGLhGllsYhlVsulsphFc.....................ss....shthuG+AGlAhFLYLElLDASFSFDGVIGAFAITsD.VlIALGLG.IGAMFVRSlTlYLV+pGTL-cYVYLEHGAHaAIGsLAlIhLlolp..aclsEllTGLlGlsaIuhuhhtSlhtNRpp	.......................................................................................................................................FDNAlVNAslL+cMoshWQ+hFLTlGILIAVFGMRLVFPllIVulsA..tlsPlcAlcLAlps...........PspYppllscuHstIAAFGGhF...LL..MlFLsFhF-ccc.l+WlphlE..p...h.....u......+.lu......p......l......s..slplhlAll.....hll.lhuthlst.spp..t...........olllAGl.hG....l.lT...a.lsVpu..luph.h-st............................................t.ts.......shsss..s....+..u.G...h..u.....t.F....L....Y....L...EV...LDAS...FSFDGVIGAFAITssl..llIAlGLG.IGAMaVRSlT..laLVc.+GTLscYlYLEHGAH...Y..AIG..s....L.A.l..Ihll.shh........h....cl..P.E..l.l.T.G.L..l..Gl.s...h.Iuhuhh....oSlphN+t.t............................................................	2	35	82	106
+287	PF04720	DUF506		Protein of unknown function (DUF506) 	Waterfield DI, Finn RD	anon	Pfam-B_4111 (release 7.5)	Family	Family of uncharacterised plant proteins.	25.00	25.00	26.30	25.50	24.80	19.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.48	0.70	-4.71	10	299	2012-10-11 20:44:42	2003-04-07 12:59:11	7	7	31	0	209	295	2	182.20	30	59.25	CHANGED	Ls-lVpuFlE-sspt.pp.p.........pusus-uSs--s-psssu.p.tcsp-clcpLL.spshc-pp...l.scltpsscps.t..................stosh+cclsshLRp.hGYDAulCKS+WcpSsc....lPAG-YEYlDVlhsss.....t.RlllDlDFpSEFEIARsTcpYpplLppLPtVFVGps-RL+pll+llCcAAKpShKc+GlalPPWR+scYMQuKWhGsYcR	................................................................................................................................................................................................................h.....p....p.t......hh...t......pt.t.......h.tph.thhpt...........................ttsshhphlsptLpt...hGasuu.l.CcS.+W..p....p..o.sp........hP.u.G.................caEYlD...V.l.h...........t...s..p................Rlll-lcFRupF..ElA.R..soppYpt.ll.p.tLP....t.lFVGps-+LpplVplhspAu+pSh+........ppuhplPPWR+.pYMpuKWhus..R.........................	0	62	148	177
+289	PF04784	DUF547		Protein of unknown function, DUF547	Mifsud W	anon	Pfam-B_3926 (release 7.5)	Family	Family of uncharacterised proteins from C. elegans and A. thaliana. 	20.20	20.20	20.30	20.20	20.00	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.49	0.71	-4.22	101	769	2009-01-15 18:05:59	2003-04-07 12:59:11	9	30	360	0	388	743	150	124.20	29	25.55	CHANGED	pls.....pph.scpEpLAFWINlYNAhslchlLpph...........lp.Slp...h.................s.a.pc.................................thhsluGpthoLssIE+tILRtp...................................hs-.PRlHFAlsCuohuCPsLc..saoupplcppL-puscc.Fl	...................................................t.ls..pph.scp-plAFWINlYNAhsh.............+sh.Lphh......lsts.tch...h........................shh.pc.................................sshsl....u.......G...p..ph.ohssIEptILRs........................................................................hs-.Ph.l+FALsCuuhos.Pslc....sYoupp...lcppLcpAtccal..................................................	0	122	263	342
+290	PF04484	DUF566		Family of unknown function (DUF566) 	Finn RD	anon	Pfam-B_3992 (release 7.5)	Family	Family of related proteins that is plant specific.	25.00	25.00	27.60	27.40	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.95	0.70	-4.91	18	186	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	20	0	122	170	0	289.00	27	56.20	CHANGED	t.....................phuosssstspssspssutcthtst...............s.ss+spshsssupt.sossspsssSpSs........................s.hspthhuPspstss.....s..h....................sPs+tppsss..........................tsssssslh...shhsshh.+uKpstschE.csHpLRLLt..NRhLQWRFsNA+s-sshhspphsAE.ptLassWhplspLps.Vsh+RltlQhh+QclKLhtlLptQhsaL-cWstlEpcHuoSLsuAhcuLcAuTLRLPlssGApuDhpulKpAlsSAVDVMpshuSSlhpLLu.KV-thsslloELuplsspEphhLp	.........................................................................................................................................................................................................................................................................................................................ttsts......................................................tsp.pth.s.pssp..ss..ss.p...h.s.s......................................................t..ss.h.s.pthh.oPsp.....tt.ss.........ss..st...h...........................sPsp.ptsss....................................................................................t.stssslh........shhs.shp..+s+t..stsp....hE.-sHpLRlLt..NRhLQWRFs.....NA+A-sshtspp.hsAE.ppLassWhphspLpcsVshKRhplQhh+pchK...Lhsl..LpsQ.......hs........hL-pWu.lEpcausuLssshcuLpAuoLRLPlssGA..........psD.hts.lppulsuAlclMpshtusltt.hhs.+spthsslls-LutlstpEphhh.........................	0	19	72	95
+291	PF04526	DUF568		Protein of unknown function (DUF568)	Waterfield DI, Finn RD	anon	Pfam-B_4977 (release 7.5)	Family	Family of uncharacterised plant proteins.	25.00	25.00	25.80	25.00	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.40	0.72	-3.71	19	208	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	26	0	118	209	0	101.80	32	29.55	CHANGED	MsGoQullAap...sus..GshpshT.slsSYss..Ltpus...LuFsVspluAp...ss............uchtIFATlpLP...sNssslNpVWQsGshst.GsshshHshSGsNlpShusLDl	.......................MsGoQALlAap.......sss...Guht..lh..Ths..lsuhss.....l..ptus......l.uasls.s.luAph..ss.............uphpIaATlpLs.....sstoplNpVWQsGshs...ussPthHs.h..su.sNlpShuslDh..................................	0	14	75	98
+292	PF04502	DUF572		Family of unknown function (DUF572) 	Finn RD	anon	Pfam-B_3967 (release 7.5)	Family	Family of eukaryotic proteins with undetermined function.	24.00	24.00	24.00	24.00	23.40	23.80	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.22	0.70	-5.21	18	653	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	303	0	474	629	5	286.40	27	91.35	CHANGED	MuERKslNKYYPPDFD.............PuKlP+h+psK....spQhsVRhMhPFNhRCsoCspY...IhcGpKFNARKEcVtsE.YLGl.IaRFYhKCspChsEIshKTDPcNsDYshEsGAoR.sapsc..........cttp-phcphcccccp........................EptsssMctLEpRTtDu+pEh-shtsL-EL+chppR..csslshsuhLcph..tcpcccptpcp-E-Dpphhcpltht......pppcp+Rhhs-..........p-tpc-.................t.sstspsspsutspsoshhspsstppspssstpphptss...................t.+sthssllhtKKptssssppst...................................tpsttpsspsssssuLstLst....hssS--s	...................................................uERKshsKYYPPDaD....................................................sph...sht.cp.s+..................pt...hh.l.R..h.hPFsh.hCssCs..pa..........IhpGh+FNAcKcpVss...........Yh.u.h.Ia+FhhKCs.tCss.pIph+TDPcN....s....D....Yshpp.G.ApR..shc.........................................ttp...ppp.h...t....t..h.....p..c..c...c....cc.........................c.ttscsMt.tLE....pcttD..pc.pthc.........h.h.ttLp..cl.pp.hp.pc......pssh.s...hs...p...h...Lcph.............hcp.pc..c....t......h.pp.....pp...c.pcp..t..h...hpph..h......................pp.tp..p.chht................................tp................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	176	266	389
+293	PF04504	DUF573		Protein of unknown function, DUF573	Mifsud W	anon	Pfam-B_2087 (release 7.5)	Family	\N	29.50	29.50	29.90	29.50	29.40	29.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.20	0.72	-3.72	21	208	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	21	0	126	194	0	93.60	31	25.96	CHANGED	thFQRl.Wo--DElslLQGhlDa.cscpGt..sshp.DhsuFa-hlKppIshcsSKsQhssKlRpLK+Kapsphp+......tsp-.sFspsHDpcsFcLu+hIWGs	...........................t..hpRl.WoccDElhlL......pGhlsa..psppGh.........ssht..Dhssha.-tl+pp.l.p.h.c.h.op.sQLh-KlRRLK+KYpsthp+........tu....tt..shppsH-pphacLu+plWs...............	0	23	58	87
+294	PF04535	DUF588		Domain of unknown function (DUF588)	Bateman A	anon	Pfam-B_1439 (release 7.5)	Domain	This family of plant proteins contains a domain that may have a catalytic activity.  It has a conserved arginine and aspartate that could form an active site. These proteins are predicted to contain 3 or 4 transmembrane helices.	21.10	21.10	22.30	21.40	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.80	0.71	-4.64	84	771	2012-10-03 17:26:12	2003-04-07 12:59:11	7	12	74	0	461	799	0	135.20	22	69.99	CHANGED	ppshphsplsLRlsshshslsuhslMuospps..h...............h.hpspasshsuapahVsusulsssYsllphshshhthhh.......tsh.hhhhhhhhDtlhshLhhuAuuAAuuls.ls......ppGstpht.h....hCpthspF.Cpps.suulshuFluhlh	............................t..hthhslhLRlsshshslsuhslMusspp........................................h.tspa.sshsu...a...pa...hlsusulsssYslhphhhshhthhh................tsthhhhh..h.....hhhD................t.......l..hshLhhuuuuAAsuls..lh..............tpu.t.t.............hC..........t....h..........s..pF..Cpph.ssulshuFhuhh................................................	1	61	279	376
+295	PF01883	DUF59		Domain of unknown function DUF59	Enright A, Ouzounis C, Bateman A, Eberhardt R	anon	Enright A	Family	This family has an alpha/beta topology, with 13 conserved hydrophobic residues at its core and a putative active site containing a highly conserved cysteine [1]. Members of this family are involved in a range of physiological functions. The family includes PaaJ (PhaH) Swiss:O84984 from Pseudomonas putida. PaaJ forms a complex with PaaG (PhaF) Swiss:O84982, PaaI (PhaG) Swiss:O84983 and PaaK (PhaI) Swiss:O84985, which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid [2]. It also includes PaaD Swiss:P76080 from Escherichia coli, a member of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation [3]. It is found near the N-terminus of the chloroplast scaffold protein HCF101 Swiss:Q8LD16, involved in the assembly of [4Fe-4S] clusters and their transfer to apoproteins [4].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-9.16	0.72	-3.99	74	6019	2012-10-01 19:25:19	2003-04-07 12:59:11	14	30	3431	23	1809	4321	2549	73.70	27	34.66	CHANGED	cpplhsALppltsP.sG.tsllstshlcs....lslps.......spVphslpls.Psps..thpsl+ppscpslt.slsG..sspVpl	......................pplhpsL.c.pVhDP.....E....ls.hslssLGl..l..h..s.........l.p.l.cs...................spl.p......l.....s.hTl..T..s.suCP....hsshltpplppslp..tlst......ps.........................................	0	581	1153	1528
+296	PF04547	Anoctamin	DUF590; 	Calcium-activated chloride channel	Mifsud W	anon	Pfam-B_2735 (release 7.5)	Family	The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes [1].	28.00	28.00	28.60	28.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.64	0.70	-5.84	102	1393	2012-10-02 00:51:22	2003-04-07 12:59:11	7	39	257	0	866	1250	37	444.10	27	58.75	CHANGED	I+sYF.....GEc...luhYFuaLsaYophLlhsAllGlhsalhthh...................................................................................................................t..hp..hsshFulhhslWuolFlEhWKR+.psplshcWshhshp.............p.p..R....spFputhh............................ths.lTs......................c..hhsthc...phh+h.lhshsllhhhlshhhshhluhhh............................hchhltphht...................hph.h.shlssll.hlhl.llshlYpplAphLTchENa+...........opspY-suhhhKhal..............................hpFlssasslFalAFhps........................................h....shpcLphplhhlhlspQlh...p.lhEhllPhlhph.......................................................................................................................hpph..............phppptpppp.......................................................................................................................pt.hhpphcp-h.phpsas..................................shh....s-YhEhhlQFGalsLFusuFPLuslhuLlsNllEl+sDthKhhp...h+RPhsp.+spsIGsW.pllphluhlulloNshllshsp................................tphpshhst...............................................................hlhhllhhE.................alhhhl+all....phhls-h.....Pptl......ptphcRpca	....................................................................................................................l+pYaGp...+luhYFuaLsh..YTthLh.sulhGlhhah.h.shh.....................................................................................................................................p......hslhFul....h.h.sl..W.....u...s..hFlE..h...WK.Rp.ps........tls.hpWshhshp.............t.cp.R...spaps.hh..............................................................hhs.hst.........................................................p.....c...h.hs.hp...ch..hhh...hhsh.shh.hhhl..hh..h......hshhhshhh......................................................hc....hhhhthht..........................................ph.hhshhsshl....hlhl........l.h..s............lY.......p.p.l.A.h.hLTph....E..+................Tp.s...pa-pphhh...Khal.......................................hpFlN...as.shFY..l.A.Fhht........................................................................h...........shhc..Lp.plhhl.h......l.spQ.hh...s.shhE...hh.hPh.h..h..ph.........................................................................................................................................................................................h.pph.........................hppt.tt.t..................................................................................................................................................................htphc.-h...pL.ts.ht...............................................shh.-..YhEh.......h....lQFGal.olF....ss.uaPL.As.lh...ALlN.NllElRhD......AhKh.sp..............h+R..........P............h................s..t.....+......s...p.....s.........I............G.........h......W...t.hhphluhlullsN.s..hl...luhsp.....................................................................tphpthhst....................................................................................................................................................h.tstlhhlllhE.................pl.hhhlphhlthhlPch....Pt.l.t.pht+..............................................................................................................................................................	0	302	410	651
+297	PF04576	Zein-binding	DUF593;	Zein-binding	Mifsud W, Eberhardt R	anon	Pfam-B_2802 (release 7.5)	Family	This domain binds to zein proteins, Pfam:PF01559 [1]. Zein proteins are seed storage proteins.	21.00	21.00	21.20	22.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.14	0.72	-3.86	26	261	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	22	0	164	232	0	91.70	43	16.67	CHANGED	lptL+ctlctp+cshpsLhpELEcERsAuAsAAsEAMuMIhRLQcEKAslpMEApQapRhhEEptpaDpEtlphLpcllhcREc-hptLctcl-	......................h.ttL+ctlptp+cshpsLhtELEcERsAuAsAAsEA.MAMIhRLQcEKAuhpMEApQapRhhEEptpaDp-slptLp-llhcREp-hppLctcl.....................	0	23	93	133
+298	PF04642	DUF601		Protein of unknown function, DUF601	Mifsud W	anon	Pfam-B_5475 (release 7.5)	Family	This family represents a conserved region found in several uncharacterised plant proteins.	21.70	21.70	24.00	23.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.95	0.70	-5.06	4	14	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	3	0	8	16	0	185.00	38	47.09	CHANGED	MuGTLEDSKLRAh-KAKp.ps-scutoRQcs...Ss.AuKsscsPTS-utossKsssuKDssKRtADKKRKpsEcDupSPsRSSRsRpEEKssu.sppKtcsKcu.sQsLV..VLSSp.SEscpSphRoo.PlPAPPhsFADhhRTLVtPGusIsPhcEhKtsN+ENYLRFAtKLGchl.EFN.sFhSHEDQL.DKDpEIESFKpsE-ENA+hV-RANpVLsRM+sAEs+VQpLElsNhDLsAKLcuGKNAY.ssI-pEspuRA-LhsCEEKh+KLEEtQAshlssARpEERRKVRAQF+DFSSKYGsFatpSEEV	...................................................................................................................................................................................................................h.th-.Elpsa+.sE--Nu+hVp+AspVhsRM+tsE.plppLElsNhDL.tKLp..........................hpth.EtQt.hl..tR............................................	0	6	6	6
+299	PF04641	Rtf2	DUF602;	Rtf2 RING-finger	Mifsud W, Pollington J	anon	Pfam-B_5482 (release 7.5)	Family	It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site [1]. This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family [2].	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.05	0.70	-5.19	23	575	2012-10-03 15:03:13	2003-04-07 12:59:11	7	9	286	0	402	606	6	231.20	20	66.07	CHANGED	MGsDGGoI..PpRcELV+h.........+++scpl...............D.ppt.ptt+WphCuLopc.Lpc...PIVsspLGpLYNK-sllchLL-Kp....thscsss......HI+uLKDlhpLplosNPs.pttt............psspps.alCPloul-h.sGph+FhhLhsCGCVFSE+AL+-l.....K...sch......................C.hCspsas.pc............Dl...ls........lNsocE.-h-hh+tch.cccpuc......pKpcKcpK+pKpstssusstpsstsstsst.................................tt..tt..t..phtptpshsppsppscsap.........SLFsoppppK	......................................................................................................................................................................................................................aphCsL.S.p.hp................P....l..ss....GplashpsllphLh..ptt.........s..ttht.....................................+lpsl....K-lh.cL.p.hsts.................................................pcspa.h.CPls..t...pth.....sspp...+hl.hl...t..ssG....s....V..ao....tcAlc..cl......c.........sph..................................................C...hh...sspsap...cp................D.l...Is.......................lp.....s.........sp.........p.......-h..........th......h.p.p..ph...pthp..p...............tp.t...pp....t.ct..t...t..................t......t......................................................................................................................t.................................................................................................................................................................	0	152	233	342
+300	PF04652	DUF605		Vta1 like	Mifsud W, Mistry J, Wood V	anon	Pfam-B_5537 (release 7.5)	Family	Vta1 (VPS20-associated protein 1) is a positive regulator of Vps4.  Vps4 is an ATPase that is required in the multivesicular body (MVB) sorting pathway to dissociate the endosomal sorting complex required for transport (ESCRT).  Vta1 promotes correct assembly of Vps4 and stimulates its ATPase activity through its conserved Vta1/SBP1/LIP5 region [1].	24.70	24.70	24.70	24.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.38	0.70	-5.06	39	629	2009-09-11 15:36:18	2003-04-07 12:59:11	11	22	297	9	412	611	7	210.40	18	49.99	CHANGED	pslp.alppApEh-ptc.PllAYaC+haslpphlchst..pssEsppah....hsLhDpLE...................phKpphs......sp.......cslh.scssupualEpFALclFspADpp.Ru.sp..hs+.sss+sFasAuhhh-llphF...Gp...................l....sp-stp+hKYAKa+AscItKul+pG........csPssss..hp-pcpt.............................................................................................................................................................t.sstssssssstsssp..s...........t.s.t..s....sss.PssP...........................................Pss......s.ss...sst.....st...............................................tstPsspp.s................................................sht.sscplspAQKaA+aAlSAL....sa-DlpTAhcpLppALclLs	..................................................................................................................................................................................................................................h.hu.pht.............................hhsahh.......thahhp.....h...ht.............ts.t..thh........lhp.....lE...................t.p.tt......................................................t.....hh.tah.thh..t.pt..p........t...................t.....hhp.h.ss..hhphh.t.h.......t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	142	230	338
+301	PF04678	DUF607		Protein of unknown function, DUF607	Mifsud W	anon	Pfam-B_5620 (release 7.5)	Family	This family represents a conserved region found in several uncharacterised eukaryotic proteins.	23.80	23.80	23.90	24.20	23.40	23.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.14	0.71	-4.35	41	400	2009-09-11 03:12:19	2003-04-07 12:59:11	8	11	197	0	257	399	0	179.00	27	53.31	CHANGED	ht.........hpstscutchssslcsuushl.slpssV..hlp.................Ppt...............hhthlt.hhsh...t..t.pp..............hlcphppclpslpchKpphcptAc......ppsp+lhWuGluhlu.sQhullh+LTFa.-huWDlMEPVTYalohushhsuYsaFLhppc-hoYpuhhcpphst+.c+hhptpsFDlpc.......YpcLp	....................................................................................................................s........tt.tpuhphsthhptsushl..hpshh........hL.....................................Ppp.................................hhphltthhsh.............tpt...h.............plcphcppL.psLp.phKtclcptAc......ppsptlh.WuG.Luhhs..sQhGllh+LTaW..-aSW...DlMEPlTYFlThushh.s..s..YuYFlhTp.p.-hsYpshhppphhtt.c+hhppppFDlp+YppL..................................	0	78	135	199
+302	PF04685	DUF608		Protein of unknown function, DUF608	Mifsud W	anon	Pfam-B_5657 (release 7.5)	Family	This family represents a conserved region with a pankaryotic distribution in a number of uncharacterised proteins.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.21	0.70	-5.74	46	661	2012-10-03 02:33:51	2003-04-07 12:59:11	8	24	450	3	246	857	87	284.20	22	30.49	CHANGED	GcFshhEuh-h.thhsohcsphY..uShuLhhLaPcLEcolhpshspsh.pps.........................GslPHDlGhs............cpPh.tss...hp....ssttWpDLsssaVLpVYRDa..hhoG-...................................................................ps...aLcphaPsltpul-ahh..p......aDpD.sDGl.-ssst.D....................................pTYDsh...hhGsouYsuuLalAALpAuhphuchlsc.........................ttptppapphlpcu+phhcch.................LWNGc..Yat..hD....................................ptphupulhuDQLhGpa...auphhGL.....ssllsc-phcoALpslachNhh.............hhhsuchGssNuhhP.......cGp............hc.ssspspE.VWo.GlsaulAAhhl.cGhh-c.uhclscsshpphh...phGh.appsEsh...t.......hhuspYhRshuhWuhhh	...............................................................................................................................................................................................................................................................................................-........hh..hh..h.............t....................................................................................................................hh.t..ha................h.ht.....hht........t......hs.p...t..sG..h.....p..s...t.h......................................................................................................................................................................p.h....h....D..s.......h.........h.....t..G......S...u....a.........s.....u..tL...a...h.s..AL.....p...u...hhthA........chhs.c...............................p.t.t.sp.pa.pthhpps+psh-pp........LW..s...Gc......aat..h...............................................................................................s.p.ptsc.h...hs-QltGph...ahp...s.uL...........s.h..hspc.+sppAhpslhch..h............................h.s..sphGhssthh...............sst.................s...hp...................................................................................................h.........................................................................................................................	0	82	143	207
+303	PF04727	ELMO_CED12	DUF609; 	ELMO/CED-12 family	Mifsud W	anon	Pfam-B_3095 (release 7.5)	Family	This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells [1]. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.	20.60	20.60	21.80	21.90	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.03	0.71	-4.71	60	873	2009-01-15 18:05:59	2003-04-07 12:59:11	8	24	242	0	533	801	13	171.00	26	34.37	CHANGED	pphphlcphtphshDspp...............................spHpch.........LppLaphhhss........................................tphssphsp................pWcclGFQ.upsPsTDFRus..GhLGLhsLlaascpaps..thpclLppspptt...........................................................................................paPaAlsuIslTt................hlhphl..ch.sph...........stcthpsh.............................htsthpsFpcLashshhtFschWh...................pptsslh-Fsplhp	................................................................................................h...t.lcphhph.hDsps................................p..H...pch.........LhpLaphhhss.................................................p.hpshhsc..................pWc.clGFp.s....s..sP......ssDFcs.s..GhLuLtsLlYFuc..p...ats..thpc.llhcspppp........................................................................................................................................h....phPFAhsuIslTp................hlhphL.ch..sph.......................pscthpth...................................................hhsp.psFppha.shsh.hh.s.+hWh...................phts.oh.-FspVh.........................................................................................................................................	0	181	274	395
+304	PF04747	DUF612		Protein of unknown function, DUF612	Mifsud W	anon	Pfam-B_3614 (release 7.5)	Family	This family includes several uncharacterised proteins from Caenorhabditis elegans.	18.30	18.30	18.80	27.70	18.20	18.20	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-13.08	0.70	-5.60	2	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	4	0	25	45	0	198.90	36	72.46	CHANGED	MRSPKSVRRPHIRQQLTNRRKNLGRVAKSQRNQFRQWLLTAVLPNSINDQRKEAFASLELTEQPQQVEKVKKSEKKKAQKQIAKDHEAEQKVNAKKAAEKEARRAEAEAKKRAAQEEEHKQWKAEQERIQKEQEKKEADLKKLQAEKKKEKAVKAEKAEKAEKTKKASTPAPVEEEIVVKKVANDRSAAPAPEPKTPTNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPASVEQVVEQPKVVTEEPHQQAAPQEKKNKKNKRKSESENVPAASETPVEPVVETTPPASENQKKNKKDKKKSESEKVVEEPVQAEAPKSKKPTADDNMDFLDFVTAKEEPKDEPAETPAAPVEEVVENVVENVVEKSTTPPATENKKKNKKDKKKSESEKVTEQPVESAPAPPQVEQVVEp.......................VEcPV..APsSKKPTADDsMDFLDFVTAKP-+oEss.......h.VEss+s-ppTAssuts+KKNKKsKpKppSEp...Ess	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tts.t..ss....ss.s.....SpKPTAD.sMDFLDFVTAKs-cs-.s............h....p.....................................t..........................................................................	0	3	9	25
+305	PF04749	PLAC8	DUF614; 	PLAC8 family	Mifsud W, Bateman A	anon	Pfam-B_3635 (release 7.5)	Family	This family includes Swiss:Q9NZF1, the Placenta-specific gene 8 protein.	21.40	21.40	21.40	21.40	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.97	0.72	-3.48	114	1148	2009-01-15 18:05:59	2003-04-07 12:59:11	12	23	216	0	794	1125	22	103.20	24	44.26	CHANGED	WssGLh...cCh........s.Dhs...sChhshh.sPChhhuph......uphhsttt................ssCshhshhhhhh............................h.....shhRs.plRpcasl............pu..s.sssDshhph.hC.sCuls........Qpt...RE...l	............................................................................................Wpsul.h.s..Ch..............s..D..h.s.........hC.hhshh..CP...C..h.hhuphtptlt.t....................................spChhhshhhshh...........................................................h......hh..hs.....shhRtplRp+a..sl...............................ps.....s...ss...sD..hhs.th.hC..sCulsQthRE.................................................	0	276	496	660
+306	PF04759	DUF617		Protein of unknown function, DUF617	Mifsud W	anon	Pfam-B_3842 (release 7.5)	Family	This family represents a conserved region in a number of uncharacterised plant proteins.	20.90	20.90	21.40	22.00	19.20	20.60	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.07	0.71	-4.60	23	195	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	19	0	135	184	0	163.50	47	61.51	CHANGED	plTGTlF.....GaRRG+VshulQ-sspus..Psl.LlELAh.sTusLh+EM..uuGhVRIALEs-+p..sspsstt...........................LL.-EshWshYCNGRKsGYAlRR..Eso-sDhtVLchLcsVShGAGVLPu............ttsssst-G-lhYMRA+FERVVGS+DSEoFYMlNP-.......Gsu......G......PELSIFhlRs	.................................lTGTlF.....GaR+G.+VphulQccs.+us.......Ps.l.LlELAh.sTusLs+EM..uuGlVRIALEC-+ppspp.s.........t..............................Ll-EslWshYCNGRKsGYAlRR...-so-sDhpVLchlcsVShGAGVLPs.................ssssus-GElhYMRA+FERVVGS+DS..EuFYMhNP-.......usu..............G....PELSIFhlRh....................................	0	15	75	104
+307	PF04818	CTD_bind	DUF618;	RNA polymerase II-binding domain.	Mifsud W, Eberhardt R	anon	Pfam-B_3687 (release 7.6)	Family	This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II [1,2].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.19	0.72	-3.73	41	1005	2009-01-15 18:05:59	2003-04-07 12:59:11	8	25	269	19	650	939	0	63.20	28	8.67	CHANGED	KLshlYLsNDVlQpu.K++...ph.pFh....psFssllssshpplhpph..spchcpplpRllslWp-Rslas	...+LshlYLhN-llp..pu...++p.............pt.pFh.............tpFppslssshpp...l...h...pph.......spcs+ppltR...l...lsl...Wpcpslat................	0	167	294	487
+308	PF04789	DUF621		Protein of unknown function (DUF621)	Waterfield DI, Finn RD, Fenech M	anon	Pfam-B_6219 (release 7.5)	Family	Family of uncharacterised proteins. Some (such as Swiss:O01625) are annotated as having possible G-protein-coupled receptor-like activity.	20.80	20.80	20.80	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.99	0.70	-5.42	14	52	2012-10-03 04:04:29	2003-04-07 12:59:11	10	4	6	0	48	64	0	200.60	40	89.57	CHANGED	huElPsp-KsslYYhlloLFVlSTlsoTLLTuuFLllullLWu+FKs........MKFFWFLoQLTlSVFIlSsLNLlINVPATLFSLlTK-FlpSclFhhlSYlIDFCHYoILFSNLVIAIQRhhVFFaRpl.TsphF-S.lIYhWLl.VWlluhhlhhhhhhsNC+Ypapp........ps..p+Y.LpCpst...sslVshssPphIQl................lEhllQhGIPlhILslYlAllhKIhhMKpooLsKsEhplLKQAIFlFllFQsSSsVFLhsQTlphsssTAFLIKRhINT..............hEIhAGAATPCFFFFTSKEIRKllSoKlSAsSSQGsS	............................................................................................pt.haa.hl.hFlh..hhsolLohsFlh.h.hhhW..h+...............h+aFWFL.pLThuhFlhS..NhhlslPAsL.ulho.phhpo...............t.a.hh....ph.h..hlhsNhhhu......................................................h.h................h.h.C.........h.........h................h-.h.hQhhlPhhI.h.hhYhulhh.......+lh.h.h..Ktss.p...p.......EhhlLhQuhhlFhhFQhss..lhhhs..h....t....AFhlK+hlpT...............h.-............................................................................................	0	14	17	48
+309	PF04802	SMK-1	DUF625; SMK-1_Ce; 	Component of IIS longevity pathway SMK-1	Waterfield DI, Finn RD, Wood V, Mistry J, Pollington J	anon	Pfam-B_6319 (release 7.5)	Family	SMK-1 is a component of the IIs longevity pathway which regulates aging in C.elegans. Specifically, SMK-1 influences DAF-16-dependant regulation of the aging process by regulating the transcriptional specificity of DAF-16 activity [1]. SMK-1 plays a role in longevity by modulating the transcriptional specificity of DAF-16 [1].	21.40	21.40	21.60	21.90	19.90	20.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.26	0.71	-4.78	25	450	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	272	0	288	477	3	185.10	41	22.89	CHANGED	l.scsYlp+L..lslFctsE-l.-shcsLHhLpsIlK..........sllLLNcsslhEhllu.D-hlhslVGsLEY.....DP-hPp.sK.pHRpaLpppu.+FKEVIPIpssplppKIHQTaRlQYLKDVVLs..RlLDDsshusLsohIahNps-IlshLQcDp.pFLpELFuhh..................pssssss-+++-hlhFL+-hCshu+sLQs.....s+ppha+sL	......................scsYIcKL..lpLFchCE-L.Esh-sLHpLapIlK..........uIl...h..L...N.c..ssl..hEhh.hS.D.-sIhcVlGsLEY..............DP.sh.s.p....s+....p....H.R.caLpcpu....+FKE.....................Vl..PIp...-s...p..l...h...pKIHQTYRlQYlpDllLs...pl..h--shhSsLsShIFF.N.pl-I.Vs..hL..Q..cDp...pF...Ls-LFuth........................................................................s.sp...ss.s.p..c++c-hV.Fl+-hCshup.sLQs.....s+pshacsL...........................................	0	91	148	218
+310	PF04783	DUF630		Protein of unknown function (DUF630)	Kerrison ND, Eberhardt R	anon	Pfam-B_2481 (release 7.6)	Family	This region is sometimes found at the N-terminus of putative plant bZIP proteins.  Its function is not known. Structural modelling suggests this domain may bind nucleic acids [1].	21.30	21.30	21.30	21.70	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.85	0.72	-4.07	33	295	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	25	0	203	284	0	60.00	42	8.62	CHANGED	MG.CstS+.l-.......s-........-sVthC+-R++hlKpAlctRpsLAuAHsAYhpSLRssGsALpcFspsEs	..................................MG.CstSK.l-.......p-..............-uVshC+-R++hl+pAlctRtsLAuAHsuYhpSL+ssGsALppFsps-.................	0	21	111	159
+311	PF01683	EB		EB module	Hutter H, Bateman A	anon	Hutter H	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains Pfam:PF00014.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.12	0.72	-3.90	63	858	2009-09-13 14:03:54	2003-04-07 12:59:11	13	76	43	0	729	809	1	57.00	25	22.16	CHANGED	C.s...........sh....hhhsspChsp.................................................st.Gps.Cp.hspQCt....ss..otC..hs....u.....pCpCssu.........hpthsst..C	............................................................................................................................tstCh.t..................................................s.t..Gps.Cp..ts...ppCt..............ss..ShC...hs......u.........hCpCss.u.........hh....s.shC....................	0	278	372	715
+312	PF04782	DUF632		Protein of unknown function (DUF632)	Kerrison ND	anon	Pfam-B_2481 (release 7.6)	Family	This plant protein may be a leucine zipper, but there is no experimental evidence for this.	19.50	19.50	20.20	19.60	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.95	0.70	-5.33	33	381	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	30	0	243	367	1	266.10	28	43.51	CHANGED	slh-llc-I-chFh+Aupuup-VochLEs....s+......h.appp.sphpt.............................uuplhpslohs...hs.ts....................htptsssttss.ts.tstoauoTL-+La.AWEKKLYcEVK.....................upEpl+hpY-KKhppLpph-t+Gscttpl-+T+sslpcLpo+lhlshpslsshSppIp+LRDcELhPQLl-LlpG.............................Lh+MWcsMhcsHchQhpllpps+..lst.....stsp..............so-tappsThpLEsplppWpssFssalssQ+sYlpuLssWLphsl........tpppt..s.s..p..sPslashCppWppsl-.cls-ctstcAlcuFssslpsl	...................................................hhphhp-lcp.F.+AupuupcVuthLEs..s+.......ht..hptp...t..t.th...........................................................ttphh.pslsht......hs.ts.............................t..s...s.h.tt...s....stshuoTL-+LhsWEKKLYcEVK....................................................stEth+hta-+Kht.Lpp.-.+G.tp....pl-+T+s.lccLpo+.lhlshpshpshoppIpclRDpELhPQLh-LlpG.............................hhpMWcsMhcpHphQhphlpphp..hs......t.....................psc.pt..ptshpLc.tlppWtssFsphlptQ+sYlpuL.suWLph..sl..........t...t......s......p.h.ssslhshsppWtttlc..plspp.......s.pulcshhtslp.............................................................	0	26	142	192
+313	PF04826	Arm_2	DUF634;	Armadillo-like	Kerrison ND, Eberhardt R	anon	Pfam-B_2700 (release 7.6)	Family	This domain contains armadillo-like repeats [1]. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis [2], control of cellular ageing and survival [1], regulation of circadian rhythm [3] and lysosomal sorting of G protein-coupled receptors [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.57	0.70	-5.27	11	392	2012-10-11 20:00:58	2003-04-07 12:59:11	8	14	78	0	216	672	4	217.60	29	44.07	CHANGED	sssphcsh.Lssp-LcKLLslLcpTcDPhIpEhALlsLGNsAAashNQ-IIR-lGGlslIushlssssspl+.pKALNALNNLSsNsENQpclKsYlsQVC-DlhssPLNSsVQlAGL+LLsNhTVTs-YQHllss.lssFhpLLstGNscTKhplLKlLlNhScNPuMT+cLlsspVsSSLluLFspp.s+ElLLplLplFpNIscplKtcuplssppcFocuoLF.hlhp-sp.hspKlpuLssH.pDs-V+tKVl	...........................................................hsstph.pc...llt.llchopDPhIpphuhhsh.up.s.s..s......a.s.h......s.p...........sh.I+c.h..Gsl.sl.ltsh.l.s.p.s.s......s....pl+....ppA....Lpsl.s...sh.oss....h-N..pt.p..l...c...h......a..l.s.p.Vsc....-h...h.s...t..s.l.......s..S...s...l.Q..h...u...G..L+hLsph..T..........l...s..sp..h..p..p...h..l...s...s.......h...s...s.h.h...p.....L.Lst.G.st..p.....s+.hplLK.lLhN.loc.NPsh....sc..c.Lls.s..p..s...ushh.sLas.....pp.spp.llphlshhppltpth+.t......s....p.......as.tsLh..hhtp.t.....hspph..t........................................................................................................	0	33	46	80
+314	PF04859	DUF641		Plant protein of unknown function (DUF641)	Kerrison ND	anon	Pfam-B_6069 (release 7.6)	Family	Plant protein of unknown function.	23.10	23.10	23.10	24.10	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.60	0.71	-4.40	13	143	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	20	0	98	139	2	124.70	33	29.11	CHANGED	spstspsspsh-ulluclFuslSSlKuAYhpLQpAHsPYDs-pIQuADpsVVuELcpLS-LK+tat+ppsssu.....spssthhAclpEpppLl+TYElhl++..LctElcsKDsEIcpL+pplppthtssppLEK+l	..........................t....pphtsh-ulluclFsslSulKuAYhpLQtApsPYDs-pIpuADphlVuELcpLS-LKchahcpphs.ss...............................st.sh.hhuph.pEppsll+o.YEhhsc+..LpuplptKDuElttL+pplpctt.ptspplpc+l................................	0	14	62	80
+315	PF04884	DUF647		Vitamin B6 photo-protection and homoeostasis	Mifsud W, Eberhardt R	anon	Pfam-B_6523 (release 7.6)	Family	In plants, this domain plays a role in auxin-transport, plant growth and development [1,2] and appears to be expressed by all cells in the plant as well as in plastids. The family has been shown to play a role in vitamin B6 photo-protection and homoeostasis in plants [3].	28.30	28.30	31.30	29.20	28.20	28.20	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.45	0.70	-5.20	27	424	2012-10-10 14:40:21	2003-04-07 12:59:11	9	9	206	0	293	410	13	219.60	31	52.45	CHANGED	sptshph.pthpphhshlhphFLPpGYPpSVosDYlsYtha........cslQshsSslsusLuTpAlLp.u...................................lGVGs.......ssAsssuAslpWlL+DuhGtlupILFAthh............................GotlDs-sKpaRlhADllsDhAhhl-l.loPhaPp......hhlhlhssusls+ulsuVAuGu.o+AuLotHF.AhpsNLA-lsAKssuQpTls..sLlGhhlGh.......hlsshls......shtsshhs.hhhlsslHlhsNYpAVRuVphcTLNcpRsslllppalps.upl.	..............................h.............hthhhthhlPtGaPpSVos-Yh..Ytha.....................cslQ.shsoshtusLuTpulLt.u................................................................................lGV.Gp........tsus..stuAs..lpWll+.Du.hGhlupllFuhh..............................................................G..sphDscsKp......aRh...hA...........DllpDhuhhlEl.hoP.....h.h.Pt..............hhl.lhshuslh+ul..........suVuu................uu.T+uulptHa...A.................h....p.....s...Nhu-lsAKs...............tuQpsls..slhGhh...lGh...................hlhphls........................s..hhhhs..hhhlshlHlhssapul+ul.hpTLNttRhpllhppahpp.s........................................	0	105	187	246
+316	PF04900	Fcf1	DUF652; 	Fcf1	Mifsud W, Wood V, Mistry J	anon	Pfam-B_6634 (release 7.6)	Family	Fcf1 is a nucleolar protein involved in pre-rRNA processing [1]. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits [1].	21.40	21.40	21.50	21.50	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.51	0.72	-3.92	60	807	2012-10-03 20:43:45	2003-04-07 12:59:11	7	10	439	0	568	803	47	95.30	35	44.72	CHANGED	hcsLhu...cspshlTpCVltELcclu..phpsulplsps.p.hpRhpCsHpss.......Ac-CIhphV..s........pc+.........YlVATpDp-L+++lR.+lPG.VPlhalp.psphhlEph	................................chLhu.csh.hlTpCVhtELEcLG....t.c....hp.hAh.....p...........lA..+...c...............t...hpc.h..p....CsHpss.....................h.A--Cllphl..p......................................ppc...........YlVAT......pDp...........cL+++lR.clPG.VPlhalp..ppphhlEt..................	0	188	312	453
+317	PF04949	Transcrip_act	DUF662;	Transcriptional activator	Finn RD, Eberhardt R	anon	Pfam-B_6952 (release 7.6)	Family	This family of proteins may act as a transcriptional activator. It plays a role in stress response in plants [1].	27.20	27.20	27.20	29.60	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.09	0.71	-4.60	6	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	19	0	44	72	0	147.50	58	88.85	CHANGED	Qh.plhsppoGulShsG.usthc-c-EEhSRSALSsFKAKEEEIER+KMEVRERVQAQLGRVEEEoKRLAhIREELEuhuDPhRKEVsslRK+IDsVNRELKPLGpTCQKKE+EYKEsLEAaNEKNKEKApLloKLhELVuESE+hRMKKLEELSKolEol	....................h.t.su.uhuh....us.thsc--EEhSRSALSsF+AKEEEIE+KKMEVREKVpsQLGRVEEETKRLAhIRE.............ELE.......uhADPhRKEVuhVRK+IDsVN+ELK.PLGpoCQKKE+EYKEsLEAFNEKN+EKspLlo+LME...LVuESE+lRhKKLEELsKsl-oh.................	0	11	27	34
+318	PF04950	DUF663		Protein of unknown function (DUF663)	Moxon SJ	anon	Pfam-B_5147 (release 7.6)	Family	This family contains several uncharacterised eukaryotic proteins.	20.20	20.20	20.50	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.82	0.70	-5.45	11	954	2009-01-15 18:05:59	2003-04-07 12:59:11	7	33	507	12	524	951	15	256.70	33	35.98	CHANGED	El-hs.c.sAcpchpKYRGL+uhhsSsWDssE........s.Pp-apclaphpNhcpoKpphlpp..............pt.hpsshsGtaVplhlcpVPhphhpsass....tp...sl.lsauLL.aEpKhullshpl++apthccPl+o..p-pLllphGaRRFhs................pPlaSp....sssss+pKhpRahpscpsssAThYuPlsassssllsh+p.psssp.............hplsAoGsllsssssphlhK+hlLsGHPaKIaK+suslRYMFassEDVpaFK..............................slplhT+sGR+GhIKEsl.GTH.GthKsoF-s+lpspDsVhhpLYKRV	...........................................................................................................................................................ht+hp.tl+thhsu.a-stE.........................st........c....a..pclh.p..h..t....ch....c.t.....p..+.....p.p.hlpc..........................t.h.tGhpsGh..hVcl..plcs..V.P..sphhp.php.............................Pl..hlhuLLtpEp+.hshlphplp...t..p..........p.h....c..c.s.lKo..+-.LIhphGhRRh.s....................tPlaSt.............pssssh...p+h.+ah....t.h....p.shAo.ahG.............Plsh..s...s...s...shls.a..pphp.sps...................................................thcl....huTGsllss..D.......t....sphl...sK+l...hL.sG..........h..PhK.Ih+..p..hshl.+.MF.s....-lthFc..............................shtlh.Th.t.G.hpG.IKcs............l....t...................s..............c....Ghh............+s.Fpspl..p...Dhlhhphah.h................................	0	197	301	442
+319	PF05057	DUF676		Putative serine esterase (DUF676)	Moxon SJ	anon	Pfam-B_5941 (release 7.7)	Family	This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.53	0.70	-5.05	14	1193	2012-10-03 11:45:05	2003-04-07 12:59:11	9	58	403	0	795	2452	363	177.00	20	25.94	CHANGED	spptsHLVVhlHGl.us..........ssDh........phltpplhp......phspc..hlhhhsppsstspThsGlch.hGcRLspEllphlpctpst..........KISFluHSLGGLltRhAluhlh.t......................httlcshsFlolAoPaLGshhspss.........ptlptshuhthlspoGppL.hh..............Ds.cspsshLh+l.tptst..hhps.......LthF.............KpRllauNs.pDthsshho.....sph	.......................................................................................................................t....pl..hlhhHG....l.us.................................tc..h............................................h.ht..p......h................................t......tt.......h....h....h..........................p....t......s.................p.....T..........t....s........hc.......h.....s..p...+...l.......h..p.....p......lh.p..h.l.p.t..h..t.t....................................p+.l..S...a..luHSLG.G.L.l.h.R.h.u.lshhhtp...........................................................p.....h..s..F.....l........o....l..uo.....P.H.......lGs............hh.tp.........h.........................................................................h...h................................h...shp..........................................................................t...........hh.h...............................................h..F......................p.h.hhs....D..s...........s.h..............................................................................................................................................	1	242	449	666
+320	PF05097	DUF688		Protein of unknown function (DUF688)	Moxon SJ	anon	Pfam-B_6331 (release 7.7)	Family	This family contains several uncharacterised proteins found in Arabidopsis thaliana.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.90	0.70	-5.54	7	218	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	22	0	135	189	0	203.30	14	61.22	CHANGED	ME-..KpLshstPLhSlRRhsph...s...pp....p..s.hp.....hP.hcs-h......pp..s.VppPuoVPFhWEQtPG+PK............st.ts...........................................................................................tcss--p-sth.-AhDTlSpstSF.hNCS.sSGlSthttss......ss.ss-..hpspDhMMuRFLPAAKAhslcp.spasu++ps.....sh.pp.hpQltchh...........sucp+ss.s.Yc.phsss....p...hcD-Ep--ps--Dt........h..ophhup+sCGhL.PplChKsSlshLNPVsuht.t....lpssSpctsK..u+hs....t..o.pK........uhs.h.c+KLpthhp.sht.s.spphpspSpp.p.h...Sps.psSp.hht...ttth.P.acsss..S..........................hpphpc..tELhhs+sshptst..Sshh-+Tlassp.p......................................hlE	..........................................................................................................................................................h.p...su.u......VPFhWEppPGpP.K........................stt..p..s..................sP................................................................sP...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.ht.tt..................................................................................................................................................................................................	0	23	78	104
+321	PF05108	DUF690		Protein of unknown function (DUF690)	Moxon SJ	anon	Pfam-B_6322 (release 7.7)	Family	This family contains several uncharacterised bacterial membrane proteins.	19.20	19.20	22.70	20.60	18.00	18.40	hmmbuild  -o /dev/null HMM SEED	483	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.67	0.70	-6.12	7	613	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	233	0	136	440	0	410.80	30	94.49	CHANGED	hshshoT+hQVoGaRFlhRRlttAlshtDsRMhsDPLRtpopulslGhllslshhhGshlhuhl+PpGtlGsssllsDRsouALYVRluspLaPVLNLTSARLlsGpssNPtsVKSSELs+hPpGsLlGIPGAPtths..sssssSsWslCDolutstSp....sstsTVIAGPh-.su.ptssLpsspulL..Vsh....susTWllhsG+RutIDLsD+AVT.uLGlss....sstPpslupuLFNAlP-ss.lpsPhIPsAGuPsShGlsss......IGuVlph.......ps.ssusQYYlVLsDGlQplssssAslLRsssSaGhstPPslsPshls+hP.sppLssphaP-pPlphVD...tstsPshChhWp+sAusssuplslluGpsLPVssu....sVpLsps.t.s...sAspVhlssGtutFVsspu..ssutsotSLaaVossGVRaGlssscs............scALGLs..ss.sAPWslLpLhssGPsLSRssALLtHDTLssDs	.........................................................................................ss+.QVoGapFlhRRhttulshtcs.c.Mht-....Ph+ppstulhhGhll...sllhhhGsh...lhu.hh.....p...P...s..u.....t...h.....u.....s.s...s..l..lss+pouuLYV..h........l..........s.........s.........p........L+PVhNLsSARLl.s..................G.......p.s..s..s.P..t..h..Vp...ss....pL..s..p....h..P.pGshlGIPG..APtth.s........ps.s..s..s.u..............s..Wsl.C....D......s..s.s.ts......ut................st.s.osl........ss.....s..h.p.ss......th..........t..Lt..s..sp.ul..L..lph..................sus.s.a.l.l........h...........s...........u.....p...........R.....t....l.....-....................s....s....p.......A....l.h......u.LGls...........stsp..lupulhsulPtss...s...lt....sP....t...l...s.......t..u...G..s..s..s..s...h...s.h..ss........lGsVhth....................................s...ss.s...paYllL.DG.lttl.s.h.hAtl.L.......p.....t....s......s.......u.............G............s...t....s.......t...ls..s..s......l...s....t.........h.....P.....s.....p............l......s....s..p......hP.s..t.....ph...ls.........htt.t.s.....s.hCh.Wp........s.........s...s..............t...t.......tsp...htl.....h.s.Gt.th.P.ls..s.........htls.ts.................s........sstVhlssG..t..u..t.aVt....stu................s...sts.s....t..o.h..a.h.lo-sGlRault.s..s..ps.............................hcsLG...Ls..............ss..........sPWsllp....hlssGPsLS+ssAhhthss..............................................................................................................................	0	31	85	123
+322	PF05127	Helicase_RecD	DUF699;	Helicase	Bateman A, Eberhardt R	anon	Pfam-B_884 (release 7.7)	Domain	This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [1]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [2].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.22	0.71	-4.64	106	1317	2012-10-05 12:31:07	2003-04-07 12:59:11	9	23	1199	2	421	2768	389	161.80	45	21.72	CHANGED	llTAsRGRGKSuulGluhutlhtpth.......plhlTAPshpslpslapashpshp..........................ttt....htht.......ttplpahsP-shhptt.ts............-l.......LllDEAAAIPlPlLcpl...ltta...+llh...........uoTlpG....YEGoGRGFsl+Fhpt.Lcpp.......................................ts.phpplpLppPIRautsDPlEpW.l.chLlLc	............................................................................t.lTAsRGRGK.SA....h....h....G..h.h...l..u..p.h....s.up.............................hhVTAP...u...hsusc...s.L.h.p.F.u........................................................................................................................................tpph.p...F...l...u.PDsLltp.....s.....pA....................................................Dh.......LllDEA.......A.A.I.Ph.P.L..LcpL......lt.t...a.....+s.lh.....................o..oTlpG.....................YE..GTGRGF.LKFhsph......................................................hs.pl+chpLppPI.RaAtsDPLEph.lschLlhD......................................................................................................................................................................	0	132	223	339
+323	PF05129	Elf1	DUF701; 	Transcription elongation factor Elf1 like	Bateman A, Wood V, Mistry J	anon	Pfam-B_8884 (release 7.7)	Domain	This family of short proteins contains a putative zinc binding domain with four conserved cysteines.  Swiss:P36053 has been identified as a transcription elongation factor in Saccharomyces cerevisiae [1].	27.40	27.40	27.40	27.50	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.27	0.72	-4.29	37	383	2012-10-03 10:42:43	2003-04-07 12:59:11	8	4	317	1	269	345	1	79.40	41	60.55	CHANGED	G+RKppp+...s.tp....+th.pLspt....FsCsFCsacpSlplpl....c+p......pthuplpCplC..stpa.psp.lstLspslDVYucWlDtscpss	..............................G+RKppp+......s.stp....KhttpLs..opFsCPFCNH-pSlpV+h......D+p..........pshGplsCplC...........tppF.pTs..Is.h.......LopPl...DVYS-WlDAC-th................	0	89	147	218
+325	PF05197	TRIC	DUF714; 	TRIC channel	Bateman A	anon	Pfam-B_9855 (release 7.7)	Family	TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalent cation-selective channel [1].	25.40	25.40	25.70	27.50	24.70	25.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.23	0.71	-4.89	13	194	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	104	0	124	182	0	184.70	41	61.19	CHANGED	l+c...pPGAlshS++sPlAsWLSuMLaCFGGulLushLLGEPPltsLsNsssILLAoslWYLVFYCPhDlhY+hssaLPl+LllsuMKEVsRshKIsuGVsHAtchYpcualVMlllGasKGAGuullpshEQLlRGVW+PEoNEhL+MSFPTKsoLlGullFTLQ+sphLslupHsLhahaTl.FhVhhKlsMhhhpsp	......................tsGu.thuR+pPlusWLssMLhs....FuuslLushLLG.EP.......ls.hpNssslLLAosl.WYllFasPhDlhY+sssa.....LP.V+llhsuM.KElhR.spKIhs.GVpHA....t+.hY....puall....MI.hlGhl+...GuGuul.hpshEpLlRGs.W..p.P.p..s..s.EhL+.SasTKsoLhuu.l.l.FsLpppp...h...Ls.huppsLhahhhl.FhVhhKl..hhht.................................................................	0	36	46	84
+326	PF01031	Dynamin_M	dynamin_2; 	Dynamin central region	Finn RD, Bateman A	anon	Pfam-B_220 (release 3.0)	Family	This region lies between the GTPase domain, see Pfam:PF00350, and the pleckstrin  homology (PH) domain, see Pfam:PF00169.	24.60	24.60	24.60	24.80	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.70	0.70	-5.64	93	2249	2009-09-16 15:19:57	2003-04-07 12:59:11	15	54	534	28	1262	2222	40	229.30	26	35.58	CHANGED	slDlLpsclhsL+hGYlsVhsR.uQpDIpspholpcAlcpEcpFFpsHstYps.hsctpGT.shLAcpLsp.LhpHI+csLPplcspIppplpphppELppY.Gssss...tstsc+sthllphlspFspsapsh.lcGpps..........ssp-LpGGu+IphlFpchhsphhps.hps..hpphhcc-lcphlcptpGhchshFlstpuFEhlVKpQIcpLc-PulcslchVh-tlpclhpphssp....phs+FPsLppplpshlpsllpcphpsscphlpshlchEtsalsTpc.sahsshp..thpp........ppppp	............................................hplltsc..h.h.......L+.h.G..........ahsVhN.........R.......uQ.t.....-...........l.........p.....t.......p.......h.......s...hp...t.........u.h.p.t.EptFF..t.p...c........................a.......p....p....h......s......p......p...hGo...hLtcpLs..........p.L.hp+Ic.pp.LP.t.l...csplpptht.phpp-lp.ph.sp.hs.........t...tpptthl..lph.....hppF...spt..hpph..l.cGptt............................pht.h.h...s....+l....................F....pp.h....h...........h...t....h......................t...............p...l..h...p.p.G............p.............hhhs...sac.ll+tpl.thlctPshptlphV..........h.p.l.phhpp.htt...............phtp.........a...P..t....Lppt..h..phh.phhp..pt...sp.p....l...........h.hthp.....h.h.......s....h..................pt.....................................................................................................................................................................................	0	336	647	994
+327	PF03028	Dynein_heavy		Dynein heavy chain and region D6 of dynein motor	Griffiths-Jones SR	anon	Pfam-B_928 (release 6.4)	Domain	This family represents the C-terminal region of dynein heavy chain.  The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains [1]. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained [2].	21.70	21.70	21.70	22.00	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	708	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.38	0.70	-13.22	0.70	-6.50	18	2690	2009-01-15 18:05:59	2003-04-07 12:59:11	10	239	285	14	1923	2507	199	542.40	27	19.03	CHANGED	hpsshssPh.-aLospsWsulptLsphpp...........FpsLscclcpss....ppW+pah-p-sP.EcpclPppWc..................ppsshpKLhllRslRPDRhshAlpsFlpptL..GpcaV-s.psl-hucsac.....-osssTPlhFlLSPGsDPhpcVEsLu+chG......ppapslSLGQGQth.lA-ptl-pAsKpG+WVlLQ........NlHLsspWLs.pLEKhL-phs....ssHscFRLFLoAEPsss.....lPhulLcsSIKlTNEPPsGl+ANL++uhss...hsp-hlEhss+p.sEa+sllFuLCaFHAVVtER++FGP.........hGWNhsYsFNpuDLphSlpsLpsaL-ts.........sKlP...W-sLRYlhGEIhYGG+IoD-aDRRLhpoaL-cahpsphh-s..-hhLsP......t.uatlPss.scacpYhpaI-p.LPsps.PhhaGLHsNAEIsahTppscplhsslLchQP+puus..ttGuu..hop.............................E-hlpsllc-ll-+ls...chFsht-lhtKhs....s.+sPhhhVhhQEh-RhNhLlp-l+pSLp-LshGl+GclshosphEsLhsuLhhspVPspWsphuYPShhsLsuWhsDLhpRlcpLppWspc........shPpslWLuGFFNPQoFLTAlhQshAR+N..pWsLDchsLps-VTK+pp-phss..s..............sc-G...saVaGlalEGARWDhp.pshlh-uc.K-LhsshPVlahKslsh..pctcpcshYcCP.VY+TcsRus.........saVashpL+o+c..psu+WlluGVALlhp	..............................................................................................................................tal.t..h.........t.h..h.........h....t.t...h.....t...................a.tt.....l.....p.pht..tt.............................ttW.p..t.h.h.pp..t.t..s........p....t........h..P.t.....hp.................................................ths.h.p......+....l....hll..+sh....RsD+..hh..sh........p.pa...l.............p................t..h..........G.............t.p....a....hps..........h.....s....h.tt....hp.....-osst....s.Pl.lhlL...............S.....s.......G......s......D........P.h..t..t..l.......t........hu.....pp.t................................tp....hpt..lu.h.G..Q.G..Q.t...hA....t..p...hlptu..h.p..p.G.p.WlhLp...........NsH.....L.s...p.a....h.....p.L..........-.c.h...h.p.p.ht............................c......sF...Rl.al..o..s..s..p..sp.............................hP...slLpt......u.....l.K.hs..E.....................sPt..........G...l.+tslhpsh.t...............................s....p.......h....p.......................s...t.....p..........t.....hptll..as..ls......ahHull.ER....++aus...........hGWsh.....Y..t..FspuDhph.........uh....p......l..p.....a.lpt....................................................t.p.ls...a.pslp.hhh.uph.......YGG+lsDsh.Dp+hh..shhpt....hhs....t...h...h..p.............t.h.h.........................................h.......h..P...............t...............p.........h..p...t.............a....h...p...a.......l...pp...L..............P.....................p...P.t.haG..hp...NA.chsh......t.p...s.p.t.....hh......pp..lh.h......p....st...st...........ttt...........s............................................................................pph...h...th...ht...p...hhpphs.............................h..s..........h..................p...h.............................p...s.h...............hhh.h..........pEh............php.Lht.lp..psL.p..........l.....h............s............l.p...G.....h......h...h.o..t.......t.h...c........t....h..pshh.s..........p.l..P.......t........W.............t......h.............s....h.s...s..............s.....ls.................aht....chh.R...h.t......hp.tWh.t..............................h.s.....hWlsuha..sp.u.aLT.....uhhQth..........sRt..........th..s.l.Dp...h.......hth.phh.....................................................................................................st.p..u.....hhl.G..Lhh-....................G.....Ata..................s.....t.......t........................l....................p.t......t......h..h......h.s...hh...h.h.....s....................................................................t..................h.......sP..lYh.......Rts.........................................hlh...h......l..............st.............th.ah.tGsshhh.....................................................................................................................................................	0	816	1017	1584
+328	PF04261	Dyp_perox	Dyp_perox_fam; 	Dyp-type peroxidase family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family of dye-decolourising peroxidases lack a typical heme-binding region.	20.40	20.40	20.40	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.00	0.70	-5.69	15	2768	2012-10-02 00:20:33	2003-04-07 12:59:11	7	7	1901	38	529	1917	88	307.60	30	85.21	CHANGED	QsGIloPhsssulalshslsutp.t......thh+phsutlstLptut................Dth.shtttt.sucLolslGhGsshac.....Rhuhs.pcPpcL+saschsssphpAssTsGDLhlaIpApct-lsFpsh+slhcphssslpVptchcGFph.........hssRsLhGFlDGTcNPpuscstct...sll......sscssshsGGSYVsVQ+ahHsl-sW-+lslp-QEslIGRcK.sssELstp....................stPssSHlsLss.c..-u.suhpILR+uhPauc.....sGph-tGLhFluYs+shcstct.lppMh.G...GssDtLh.-aopsloGuhFFsPsssph	.............................................................................................................................................................................QsGIhs......t....ptssha..lshslt..st............................thht.....hstthstL..ptut.h.............................-ph..hthhh.ssspLohsluhGsshac..............ph.uhs...t..t..........P....p....c.L.c..c....hs..t..a.ss.s..p.h.ps.........s.h.o.puDlhlpIpus.cpslsapshpslh..c..t..h.....s.s...h..l...pVc..chc.GFth...............................hssR..s..LhG..FhDG.......TtNP.....pup......pstph..........shl.....................t-t.........h.htGGSYhhVp....+hpap...lct.W....cR..............h........s....l..........c-.......Q..........E..............p.....h...hGR.sKp....s.st...lstp...........................................................hhPtsSHlphss........c...t..........p............s....p......s..........h.....p.........I......lR+uhsYus................................sut..h.-t..GLhFluYppshcph.h.lpshh................u.....p.tDtL.....c....a.sp.sl.s..GuhFFsPshs..h....................................	0	143	307	438
+329	PF02221	E1_DerP2_DerF2		ML domain	Bateman A, Yeats C	anon	Yeats C	Domain	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 (Swiss:Q15668) causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.33	0.71	-3.91	137	1034	2012-10-01 19:31:57	2003-04-07 12:59:11	10	11	326	68	586	1089	2	125.90	20	73.86	CHANGED	shshpsC...s.t.....sphpplsls........ss..hslhpGpsh.slshsh.ss.pp.spshps...plpsphss.......lplsh............csCc.........................pCPl.ptG.phhshphsh.s.........ls.p.hPss.....phplphplhsp.s.sp..tl..sChphsspl	.................................................s...hp.C.....st......hp.lpplsls..........ss....hslhcGpsh.s.....lphsh.ss......ppssps.h.ps..plpsphss.........lpl.sh.................shCc..............................shpC.....P.....l.ptG...ph...........s.hphsh.s........................l..p.hPss...........ph..plphplhsp.s...tp...pl....sChphsht................................	0	239	316	476
+330	PF03271	EB1		EB1-like C-terminal motif	Mifsud W	anon	Pfam-B_1529 (release 6.5)	Family	This motif is found at the C-terminus of proteins that are related to the EB1 protein.  The EB1 proteins contain an N-terminal CH domain Pfam:PF00307. The human EB1 protein was originally discovered as a protein interacting with the C-terminus of the APC protein. This interaction is often disrupted in colon cancer, due to deletions affecting the  APC C-terminus. Several EB1 orthologues are also included in this family.  The interaction between EB1 and APC has been shown to have a potent synergistic effect on microtubule polymerisation. Neither of EB1 or APC alone has this effect. It is thought that EB1 targets APC to the + ends of microtubules, where APC promotes microtubule polymerisation. This process is regulated by APC phosphorylation by Cdc2, which disrupts APC-EB1 binding. Human EB1 protein can functionally substitute for the yeast EB1 homologue Mal3. In addition, Mal3 can substitute for human EB1 in promoting microtubule polymerisation with APC.	21.10	21.10	21.10	21.50	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.18	0.72	-3.91	61	559	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	308	17	346	525	3	42.60	52	14.59	CHANGED	slEcERDFYFsKLR-IEllsQp..............ctppps..lh......................pcIpcILYu	.....LEKERD.FYFuK...LR-IEllCQc.p............-t-sss....ll......................pcIhcILYA.............	0	102	172	257
+331	PF05009	EBV-NA3	EBNA-3;	Epstein-Barr virus nuclear antigen 3 (EBNA-3)	Moxon SJ	anon	Pfam-B_4674 (release 7.6)	Family	This family contains EBNA-3A, -3B, and -3C which are latent infection nuclear proteins important for Epstein-Barr virus (EBV)-induced B-cell immortalisation and the immune response to EBV infection [1].	24.40	24.40	274.20	273.20	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.64	0.70	-5.13	11	121	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	6	5	0	56	0	235.00	84	38.12	CHANGED	MAlRQRlpDlRRsPhshcs...QR+W+LsSPupoW.MGYRTtolhhhoassstssss.lhLsAThGCpsGtRstsTFSAGsapPP+sust-QchhsspupVtplRppsscRY+hFFD.hlsltpSLptIWpslLps-.pRlsFhcFlGaLs+s-pshl+hWaccslGsh+sppPWhpssPst.sac..cslsscshstAah+GpshGlshLtssu.E.tcssssETssEpE......DsEs-u-D-..........plPpIlPp.t..shppRPslFlpR	..................................WPMGYRTATLRTLTPVPNRVGADSIMLTATFGCQNAARTLNTFSATVWTPPHAGPREQERYAREAEVRFLRGKWQRRYRRIYD.LIELCGSLHHIWQNLLQTEENLLDFVRFMGVMSSCNNPAVNYWFHKTIGNFKPYYPWN.APPNENPYHARRGIKEHVIQNAFRKAQlQGLSMLATGG.EPRGDATSETSSDEDTGRQGSDVELESSDD..........ELPYIDPNME..PVQQRPVMFVSR.	0	0	0	0
+332	PF00679	EFG_C		Elongation factor G C-terminus	Bateman A, Griffiths-Jones SR	anon	Pfam-B_40 (release 2.1)	Domain	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a  ferredoxin-like fold.	24.00	24.00	24.00	24.00	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.83	0.72	-4.12	172	18629	2012-10-02 20:07:24	2003-04-07 12:59:11	19	79	5330	69	5120	13346	6308	88.10	29	13.46	CHANGED	hlhEPlhplplpsP.....p-hhGslhsplsp.RRG.plhshpsp.........ss......tshlpsplPhsphh.satscL+ohTpGputhshpa..spYp.sssphhpph	......................lhEPhhplp..l...sP...................c-a.hGs.Vhst.ls....p.RRG..ph.hsMp.p...................ss........................................tstlp..hpl.PlsEhh..Ga...tscL+ShT...pGpu.s.h.s.hp.F..scYp.sshsh.t..h............................	0	1815	3287	4370
+333	PF03764	EFG_IV		Elongation factor G, domain IV	Bateman A, Griffiths-Jones SR	anon	Pfam-B_40 (release 2.1)	Domain	This domain is found in elongation factor G, elongation  factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.12	0.71	-4.54	81	9390	2012-10-03 01:04:38	2003-04-07 12:59:11	13	49	5414	57	2657	7106	2810	117.60	36	17.30	CHANGED	sp.Vua+E.hhpssc.tptphtcp.sGhcspau+hhlphcP..........ssuh.Fhstsp....GstlscEahsulppGhppuhppGsLusaPlhsl+lsLhDushHs..lcSoshsap.Auphuh+puhhpAp	....................................................................PpVuYREThp.pssc.hc....tpat+Q...o.GG....c.G.Q....a.u..clhlp..h...p.Php........................spGh....p.F.......s..plh...................GG....s...l.P...c......E...............a..lsuVpcG.l.p.p.uh.c......p.GlL....A..G....aP...........lh..Dl..+ssL.hDGuaHs............VDS..o..p...hAF.+hAuphAh+puhpcAt.....................................	0	986	1715	2277
+334	PF00036	EF-hand_1	efhand; EF_hand_1;	EF hand	Eddy SR	anon	Prosite	Domain	The EF-hands can be divided into two classes: signaling proteins and buffering/transport proteins.  The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site.  The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.44	0.74	-7.46	0.74	-4.24	893	3781	2012-10-02 16:17:27	2003-04-07 12:59:11	27	216	892	544	1838	18263	638	28.50	33	12.77	CHANGED	plcphapthDp-ssGtIshpEhtphhpph	...........lccsFphaDpDssGhIshpEhhphhp............	0	649	934	1356
+335	PF04189	Gcd10p	eIF3_gamma; 	Gcd10p family	Wood V, Finn RD, Bateman A	anon	Pfam-B_8933 (release 7.3);	Family	eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3 [1,2]. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA [3].	21.00	21.00	22.70	22.80	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.77	0.70	-5.28	34	336	2009-09-13 16:20:58	2003-04-07 12:59:11	8	6	291	0	241	322	10	288.60	26	61.49	CHANGED	pshIp.spaVllc.hsu-thKlVclpsss....hlpLGKhGsF.lssllGhsaGpoFEIh.sp.................ph.h.l.psph.tpph.sp......................t.ttt......t.tpsscsN+sll.......Dsup.sQK..Lot--IppLKcp.stu...Gp-IIppllpsppoFcpKTtFSQ-KYl+RKccKahcha...Tl.h.ssshLsphahcc..-s.......t+lhclRt-oLuhlLshuNl+s..............sG+YLVhDc.TuGLlluAhhERMuu..........................................pGpllthapspt.sshs...hLchhs.....t..ts.p..pttlpslshhthhcs........ttpppppp.sshspc-hsshcss	...................................................................hIp.spaVll...h.sphh+.hh.p.lp..st....................plp.lGK.t.h.hspllGpsastoFE..lhspt............................................p.h.t.t...........................................................t.....................ptpp...s.spsNR.sll.......Dssp...sQp..Lot--IcpLKcp..uhs....................Gc-IIppLlpspsoFcpK.TtFSQpKYlp+KpKKYhp...hh..............plh..sssp.lsphahtc..-s..............s+lh.plR.h-oLu.lLshuNl+s....................................................................su+hLlh-s.suGLlsuAhhERhGu...................................................................................................pGsllphh....ss...s...sshs...hlphhs...hs.p...........p...t.......h....th.l.plp.h...p.......................................s........................................................................................................................	0	83	133	201
+336	PF03610	EIIA-man		PTS system fructose IIA component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.00	21.00	21.00	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.41	0.71	-4.02	36	8406	2012-10-02 12:41:15	2003-04-07 12:59:11	11	38	2718	39	912	3993	258	113.60	21	41.09	CHANGED	ulllsoHu.chApGlhchhphlhGc....sltslshhss..tshsshtppltpAl.pphsts-tllllsDlhuuss.stsst.hhcc.t..ht...hlsshslPhlhpuhsst...sphshsphhsplh	........................tlllsoHG.phApulhpssphl...h...Gp....t..p.lt.s.l...s..h.h..ss..........p.ssssh...hpcl.pptl.....p..p..h....s....s....sc......s.lllLsDlhu.u.o.shst...ss..p...h...h...h..c...t.p......hp.............llsGhNlPhll...pshhtp.....tths.h.tt.ht...h.......................................................	0	255	550	740
+337	PF01448	ELM2		ELM2 domain	Bateman A	anon	Bateman A	Family	The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex [1]. The domain is usually found to the N terminus of a myb-like DNA binding domain Pfam:PF00249. ELM2 is also found associated with an ARID DNA binding domain Pfam:PF01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.86	0.72	-3.32	53	960	2009-01-15 18:05:59	2003-04-07 12:59:11	19	46	123	0	518	897	2	55.30	31	7.90	CHANGED	IpVGsc.aQ.....AcIPphtspspppppppt.........................ccpl...lWsP.........s....tlsc...ppl-p.......alp.hupspt	.............IpVGsp.aQ...........A.-..IP-.hhsps...ptspcp...pp...............................................................................tcpL......VWsP.........p...sls-.......pcl-p...aLs.hApp..s......................................................	0	109	160	306
+338	PF02990	EMP70		Endomembrane protein 70	Griffiths-Jones SR	anon	Pfam-B_1312 (release 6.4)	Family	\N	22.80	22.80	22.90	23.10	21.20	22.70	hmmbuild  -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.91	0.70	-6.04	15	1526	2009-01-15 18:05:59	2003-04-07 12:59:11	11	27	425	0	910	1437	39	423.80	34	82.92	CHANGED	hsYcYYs..LsFCpPpp..lpcpsEsLG..EVLpGDRlhsSPaclchhccppCpslCpp.......plspccschlpctIppsYahpallDs.LPlsspltphcs...........h.h..Gah.s.p.......................................pspKhYlaNHlchhlpYH....cc.........RllslpVpshSlc...............p...........ppP.hlcEsp-.......lhFTYSVcWpcoc.lcWuo...RWDtYLc......hpshpIHWFSIlNShllVlFLoGlVuhIlhRTL+pDlu+YNp.-ptp.............DspEEsGWKLVHGDVFRsPp....pshLLSsllGoGsQlhhMlhsslhFAhlGhLuPusRGuLhTshlllYslhGhluGYsSuplY+phcGp..................pWKpshlLTuhLhPGslFshhhlLNhllWupsSSuAlPFuThlhllslWhhlSlPLohlGullGh......Rppsh..csPsRTNpIPRpIPp..QsWYhpslhuhLhuGlLPFGuIaIELaFIaoSlWtpc..hYYhFGFLFlVFlILllssuploIllTYFpL..CuED....Y+WWWRSFlsuG.uoulYlFlYSlaYahsKhp.lsGhh	...........................................................................................................................sYpYat..hs.a.Cts....t..........................t................................t..........sLG..p............lL...Gccl....o..a.p.....hp..h....p......p....p..t.....hh..Cp....................t.h..s.t.t.p.hp.ht.phlppt.Y.hphh.....................l.Ds.LPhhh..h....h....tt................................................................................................t.tt.p.h.h.l.sHhph.......l..ap..................t.p..........................................................pllt.hpl.s.......t........................................................................t.......l.t....t..tt...........l.aoYsVt.a.p..sp....hta..ts..............R.aD..h..ah.t.......................p.plHWh.....................SlhNSh..h....h.VhhLs..........u.h.l..shI.h.hRs.L.+.pDhs..pYs.p..pt.t...............................................t..t-....-.GW.K.llHGDV.FRs.Pp.........t.shlLsshlGsGsQlh...hhshhsl...h.h.......Ahl............G...........h.........ls......PspRGu.l.hT...shlhlashhu.hh.uGYsuu..p......h...Y+ph....t...Gp..........................................pWh..pshh....hT.uh..lh...Pu..hlFsh.hh.hl...Nhhhhs.......t...S...ouAl..PFsThl.s.llhlW.hhlslPLshlGuhhG..........................+p.sh...p.Ps......+..s.....s.pI.PR...p......I......P............p........a....ah........p.....s.........h..h....l..hu..GlLPF..u..sl....alE...L....a.FI.h...............s.S...l..W..pp.....hYa...ha..G................FLh.ls..h..h.........l....L....h.lssu.plo.l.lhs.Y.h.L........s.sE.s..................a.pW.Wpuahsuu.ssu.halhh..YuhhY...hh..c.p.h.t..h.........................................	1	327	520	748
+339	PF01223	Endonuclease_NS	Endonuclease; 	DNA/RNA non-specific endonuclease	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.68	0.70	-4.70	59	2367	2012-10-05 18:28:12	2003-04-07 12:59:11	18	35	1457	25	866	2278	269	199.70	19	53.76	CHANGED	hhptaslsaspp..pchshasttplsssshttspsp.....................................spat.-.slsst.hpst.ssatsth.......aDRGHlss.......sspthspss.psTFhh.sNhsPQ.htshNp..ss.........WttlEshsRphsp...............ptpslhlhoGshhh.s.........................................................ttlslPphhaKllh..ts.t.................htuhlhspts..pth...............tt.............h.hsl.tl.t.......sG..lsahsslsst	.........................................................................................................................................h....as.sastp.....pchs.asu.p...l.pt..ps.htttptp................................................................................ttspa....t....-..s...pl..s....t......t.....h....p..s.t...ss...Ypt.su......................hDRG.Hhss...............sshph...u..p.ps.psoF.hh....oNhsPQ..t....t......shNp.....sh.................W......s.t.l.E.p.h.l.R.p...h...s.p....................................ph.p.slhVhoGslhh.p.........................................................................h.h.t.tspl....lP...phaaKllh.s.pttt....................................h.uahh.pt.....t.........................................................................h.httlpt.......................ss....hphh......t..........................................................................................................................	0	233	407	665
+340	PF00812	Ephrin		Ephrin	Bateman A	anon	Pfam-B_1390 (release 2.1)	Family	\N	25.00	25.00	25.20	25.70	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.06	0.71	-4.70	14	554	2012-10-02 17:41:00	2003-04-07 12:59:11	12	4	91	31	288	430	1	131.80	39	52.16	CHANGED	tsuuscasVYWNSoNs+Fhp.pshsltlpIsDhLDIlCP+hEss..........spshEhYhLYMVsh-thcsCph.tpcsphhhpCs+Pps.......................sPl+FopKFQcFoPhshGhEF+tG+-YYYISosssshtsp.......ChphphpVhh+sup	..............................h.......h.Ws.s..t..N..+...............Fh......t...t............sh.sl...tlp.l.s......DhLDIhCP+hcss.........sttphE..hYh.LY...............hV.s.t-tacsCph...p...pp..s.h.hhhp.Cs+Ppt........................slKFo.KFQcFoP.s..hGhEF+sG+-YYaISosssst...tth.........C...hphp.hhlhhps.................................	0	47	74	164
+341	PF05139	Erythro_esteras		Erythromycin esterase	Bateman A	anon	COG2312	Family	This family includes erythromycin esterase enzymes [1,2] that confer resistance to the erythromycin antibiotic.	26.30	26.30	26.80	26.80	25.40	26.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.09	0.70	-5.25	73	695	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	516	4	246	666	50	310.70	22	67.58	CHANGED	slAlEuDWPDAhpls+YVpst.ss..................sspt............tsapRFPtWMW.RNpEhhchlcWLRsaNsshs.....tpc+...lsFaGlDlY....ShtsShpsVlp...YLcpsDPptA.......ptA+ppYushs.h.sccsttYGhtsh....t..hpssccpllppLpcLhppthphttp...ts....-chh.ApQNAplltsAEpYY.....+sMhtstsps.......WNlRDpHMs-oLptLhcph..stp.....uKslVWAHNoHlGcApuTphu.........ts.hslGQll+-paGcc.shhlGhsohpGsVsAuspW......ssshphhplpPuhssSaEplhcpsuhspallch...........ssthtphL..tp...RhpRuIG.VlYpPco..Eh.SaYhpssLscQFDullah-cT	.....................................................................................................................luhEssassuh.t.l.scYlpst.ts..............................s.p....................hppa...th..ha..psp-hhshl.cWhRpaNtp..............ttpp....lthhG.hDl...........s.tp.s..h.p.t.lhp.......Yl.c.p.h.s...sphh...............ttscpt.h..tth....p....h...tppsthh.sh................htppppphhpthpclhphhtp..ttt....s.................cphhhs.ppsAphltphtphh.................pshht.s..s.pp.....................hsh.....RD.ptM.h-slthlhcph......t.......................u+hlVWAHNuH..l.ucspss.hh.................................t.hshGphlpc.p.hGcp....hhslGhsshpGphsshpt.........st.hthhtlts.s..ssShE.t.h..h.t.p...s...s....h......s......t.hhlsh................pt.ht.thl..tt...t..hhh.....G....shhhst..........hhh....ht...ptaDshlahpp........................................................................	0	83	170	220
+342	PF04800	ETC_C1_NDUFA4	ETC_CI_21; 	ETC complex I subunit conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6275 (release 7.5)	Family	Family of pankaryotic NADH-ubiquinone oxidoreductase subunits (EC:1.6.5.3) (EC:1.6.99.3) from complex I of the electron transport chain initially identified in Neurospora crassa as a 21 kDa protein [1].	25.00	25.00	25.10	26.80	20.80	24.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.35	0.72	-4.15	6	625	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	542	2	330	566	1035	98.40	40	65.94	CHANGED	RpsRIYpPA+sshQSGpu+spcWpl-F-.spt...RWENPLMGWooouDPlup...hcLoFsT+E-AluFAE+pGapYpVcEPps.+hKsKuYusN.......Fuas++pp..h	...............psRIYpP.A+.sAMQ..SG..p.s....pT.......c......p.......Whl-a-....ppt....R.h..sPLMGWsSS......uDshsp.......lpL..pFso+E-AluaAc+pGhsY.pVp.E..Pp.............p...............p....h..+.......+...u...Yus..N.......Ftas+.t.h..p.......................	0	107	195	261
+343	PF04716	ETC_C1_NDUFA5	ETC_CI_29_9;	ETC complex I subunit conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4159 (release 7.5)	Family	Family of eukaryotic NADH-ubiquinone oxidoreductase subunits (EC:1.6.5.3) (EC:1.6.99.3) from complex I of the electron transport chain initially identified in Neurospora crassa as a 29.9 kDa protein. The conserved region is found at the N-terminus of the member proteins [1].	20.10	20.10	20.20	21.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.69	0.72	-4.44	32	283	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	238	0	190	282	2	58.80	37	34.55	CHANGED	ssP+tsLhsLYschLcpLp.phPcsusYRptTEtlsppRLplVcp......ppshcclEpp...lss	....sP+psLhhLYschLctLp..phPcsu.sYRptTEtlTpcRLslVcp..............-tslpclEcpls......................................	0	66	104	156
+344	PF04621	ETS_PEA3_N		PEA3 subfamily ETS-domain transcription factor N terminal domain	Kerrison ND	anon	DOMO:DM04577;	Family	The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding [1]. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades.  The N terminal region contains conserved MAP kinase phosphorylation sites [2].	30.00	30.00	30.10	30.10	28.10	29.90	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.48	0.70	-5.21	10	264	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	49	0	96	260	0	269.80	47	68.50	CHANGED	MDGFYD...QQVPFhVss.sppu...ppstsRsss-RKRKF.lso-LAp.......DoEELFQDLSQLQEtWLAE......AQVPD.DEQFVPDFQS-N.LhFHGPP.sKIK+E.pSPup-h.SsCSpcps.shsaGEKCLYsh..........................SAaDpKPssuhKPsoPsoTPsSPhss.sth....uotPhpcsosss...........................hthPh.sps.P.hls.Ps.s..sssass-pR.......FpRQLSEPChsFPs.suth................s+-sRPsYaRQMSEPhlPh...PPQGFKQEhhDPlYscpGhPs............stsap.....tshsIKQEPRDFsaDSEVPsCpSsYh+ssuF...sstp-..Gata-+-s+hFaDDoCVVPERhEGclKQE.suhaREGPPYQRRG	........................................uhhDQp.V....Pah.st..pp.s.....tt.ttt....h.sp.t+hh...sp.......s...............DSE........-LFQDLSQhQEsWLAE...................A.Q.VPD..DEQFVPD.apu-s.......L..................sFHu.P.hKIK+E.pSPso-..puCSpcps.h.hsaGEpCLYs......................................sAY-p.p..suh+s.sPssss......oP...................h..hpttu..s...................................................................................Ph.....spt.................h..s....c.pp.......................................a.p.Q.sEs.CpsFss..s................................sttsts.YpRQhSEP....hPh...P.QuFKQEYhDPlYEp..t.shsu...............................s.stp........sshhIKQEPpDasaD...S..-...VPsC.t.......S.Yh+tt.sF.......st.pt.........Gh.a-Ks.R..a.DDsCVVP.E+h.-.G.clKQE.ssha..REGPsYQRRG...................................................................................................	0	7	15	38
+345	PF04777	Evr1_Alr		Erv1 / Alr family	Finn RD	anon	Pfam-B_5005 (release 7.6)	Family	Biogenesis of Fe/S clusters involves a number of essential mitochondrial  proteins. Erv1p of Saccharomyces cerevisiae mitochondria is  required for the maturation of Fe/S proteins in the cytosol. The ALR  (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the  mitochondrial intermembrane an d it thought to operate downstream of  the mitochondrial ABC transporter [1].  	25.60	25.60	25.90	25.80	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.63	0.72	-4.09	59	881	2009-09-10 22:39:07	2003-04-07 12:59:11	8	18	378	43	544	854	401	96.80	29	29.08	CHANGED	puhWshLHshuupaP..pp...Potpp..........pp...shpsahphhsphaPC.ppCupcFpphht....p..tssp.............lso+cshstWLhphHN..pVNp+LuKs...................s..sph.pppats	..................................puhWp.lhHohssp.as....cp.......Po..tpp....................pp...shpshhphh.sph.aP.C..p.............cCupc..Fp.phhp............c......p.sp.............................lp.o.ppshshWlhphHN..pVNp+LuKs...................ps.sph.p.pa..s.............................	0	190	296	442
+346	PF03372	Exo_endo_phos		Endonuclease/Exonuclease/phosphatase family	Dlakic M	anon	Dlakic M	Domain	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.30	0.70	-4.44	326	20400	2012-10-02 01:25:08	2003-04-07 12:59:11	18	388	4759	145	7593	17817	4636	258.00	13	59.21	CHANGED	h..oa..Nlpt....................................................................................ltp.........hlppts.................sD..lls.....................lp....Esp............................................t.h...tthhtt.......hs...tt.h........................................shslhs+h................s..httthhthh............................................sttththhhthtttth...............................................................lh...ssH..............................................hss................tstttp...t.phhpth........tthhtt................................................hllhG.DhN...........................................................................................tshh....stth......pshpthh...h.................................................................................tl........Dalhs.............htththtththht...........................................SD..H	................................................................................................................................................................................oaNlts....................................................................................................lhp.....................hl......p.p.s................................sD......lls.....................LQ..........Esp..............................................................................................................................................................................................p.h........tthht.h.......................h..................h.............................................................................................................G.lu.l...h.s...+.h.................................................................h..t..h..h.t.thh............................................................................................................................................................................stt.t.h.h..............h..h.h..h.t..t.........................................................................tt.tlh........lh......ssH........................................................................................hss......................................ttpttp............ht......thh.phh......................p.phh.ptt.............................................................................................................llls.G..Dh.N.........................................................................................................................................................................................................................................phh................p.t.h......................p.h.h.p.t.h...h..t................................................t..h...shtht..................t..h...............................................................pl...............D.alhh......................................................thh.h.t.t...........................................................SDH.............................................................................................................................................................................................................................................................................................................................	0	2415	4456	6161
+347	PF02609	Exonuc_VII_S		Exonuclease VII small subunit	Bashton M, Bateman A	anon	COG1722	Family	This family consist of exonuclease VII, small subunit EC:3.1.11.6 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones [1].	20.80	20.80	20.80	21.30	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.35	0.72	-4.19	148	4033	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	3983	6	847	2207	1003	52.90	37	66.86	CHANGED	FEculpcLEpIVpcLEsGclsLE-ulchaccGhpLhcpCpptLppAEp+lphl	..................FEculp-LEpIVpcL.E.s.G.-ls.LE-ulshac+GhpLs+pspppLppAEp+lphl...........	0	283	566	723
+348	PF00929	RNase_T	Exonuclease; Exonuc_X-T;	Exonuclease	Bateman A	anon	Pfam-B_1153 (release 3.0)	Family	This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.; 	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.07	0.71	-3.96	57	17634	2012-10-03 01:22:09	2003-04-07 12:59:11	19	169	4800	65	4662	12914	5053	160.30	21	36.06	CHANGED	lslDsEsTGhss..............hspllEluslplsstt...........htt.hphalpPpp...lsshsschsGIosth..lpstsph.p..shpthpphhp.t........phhlsps..hsh.hshhhpp.hchhhh.h......ht.hhcththspthhtthtt...........sLstlspphthpt.pp.......HpAlpDsptshplh	............................................................................lhlDhE.T.T.Ghss...........................ttsc.ll...-..l.u.s....l..pl..pssp.............................hssphp.h..h...l...p..P..p......p..........................l.....s....s..h...sh...p....l....p.....G................Io....s...ph.............l..p..s...t..s...s.......htp.......shp.p....h.h.p.....h...l....p.....s...........................................th..hVu.....+......N.....s......s.....FD.....hs.hh..t.t.p.h..t..c..h.h.h.h...hs.........................p.s.h...h..c.s...h..p....l...s..p....t.....h......h....thtp................................hpL.s.p.l.sp...t...h....s..l...p.h.ppt.....................H.p.AltDsptospl...............................................................................	0	1427	2706	3817
+349	PF03016	Exostosin		Exostosin family	Mifsud W	anon	Pfam-B_2031 (release 6.4)	Family	The EXT family is a family of tumour suppressor genes.  Mutations of EXT1 Swiss:Q16394 on 8q24.1, EXT2 Swiss:Q93063 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia.  EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities [1]. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.97	0.70	-5.38	33	1543	2010-01-08 15:44:36	2003-04-07 12:59:11	10	45	197	0	1043	1489	205	267.00	21	51.06	CHANGED	tpsshpVYlYcls......................................................pshh.sppash-hhlhpplppsp........hhstcPscAslFalPhhsshp.......................pphh.t.l.phhpph..shW....pc.tGcD...Hllsssps......................ssthhh...thtspshhsl....h..s...................ptphh.spD...lslPshhpssshssthst.........tpRphLhhFsGshtht..t.................ttslRstllcph..........ts..sst.t.......................tptppts..p..........hhchhpsupFCLh.PtGt.p......sptplh-ulhuGClPVll.uc.......shp.....LPFtshl.DapchoVhlscpcl......splhphLcsl	...............................................................................................................................................................h....hhlalY.........................................................................................................................pt......ht.......t..hh.hhttl......pst..................................hhstssppAshahl..s...h..sh.........................................................t.t........h.......t.l.....t....h....h....t....ph............sh.W......................pc......Gts......Hh..hhshts.............................................................t..........thh..shhsh.................t..........................................................................ptthh.thD.......lshP..h.....h..........ts....t....h........................p.......R..ph.L.h..h.F..tG.t....h...................................................................ttth+.h...lhp.p..h.....................ps....tt...p.......................................ht.t.t..t...p...............................hhphh..tpS.....pFCLh...Pt.Gt...p..................ss.Rlh-ulh.sGC..lP....Vll..uc......................ph......LPa....t...p.hl....sapphu...lhlsppcl..............pl.phLpt................................................................................	0	337	682	871
+351	PF03124	EXS		EXS family	Mifsud W	anon	Pfam-B_605 (release 6.5)	Family	We have named this region the EXS family after (ERD1, XPR1, and SYG1). This family includes C-terminus portions from the SYG1 G-protein associated signal transduction protein from Saccharomyces cerevisiae, and sequences that are thought to be murine leukaemia virus (MLV)  receptors (XPR1). N-terminus portions from these proteins are aligned in the SPX  Pfam:PF03105 family. The previously noted similarity between SYG1 and MLV receptors over their whole sequences [1] is thus borne out in Pfam:PF03105 and this family. While the N-termini aligned in Pfam:PF03105 are thought to be involved in signal transduction, the role of the C-terminus sequences aligned in this family is not known. This region of similarity contains several predicted transmembrane helices. This family also includes the ERD1 (ERD: ER retention  defective) yeast proteins Swiss:P16151.  ERD1 proteins are involved in the localisation of endogenous endoplasmic reticulum (ER) proteins. erd1 null mutants secrete such proteins even though they possess the C-terminal HDEL ER lumen localisation label sequence. In addition, null mutants also exhibit defects in the Golgi-dependent processing of several glycoproteins, which led to the suggestion that the sorting of luminal ER proteins actually occurs in the Golgi, with subsequent return of these proteins to the ER via  `salvage' vesicles [2].	25.00	25.00	26.30	25.10	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.26	0.70	-5.42	68	815	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	326	0	551	823	12	287.00	27	50.36	CHANGED	hhh.lapshhLlllhhahaulslahWpptplNa..s....hIhchs..........................ppplshpphhp.............lushhs.................................hhhslshhhhhhh.h.t...p.hth.................PhhhlhlhhhlllhPh....phh........htpuRhahlpslhRllhush....h.VpFsD..FaLuDtLsShshsltDlthhhChah..h.h.............ptt..............stCtpsphhh............sllsslPshhRhhQClRR.ah-spct...............sHLhNAhKYssshhshhhtsh..hchppspt.......................hhhhalhsuhlsShYshhWDlhhDWuL.........................hpps.t.s....................................cshhLR..ccLha.............sp.......hhYYhAhlhsllLRhsWhhp..hh.................pht.hh..pp....plhshl...luhlElhRRhlWsFFRlENEHls	..................................................................sh..hath.hhhh.hhhhhshsh..h.hap..t..tl...sa..s......hlhphp...............................................tpthp.tphh...............................................hsshhh..........................................................hhhh.h.hhh.hh...............................................Phhhh..hhhhh.....hlh.Ph....thh.....................................hpsRhhhhhhh................hRlh.hush............h.ltFtD..haluD.lsSh......s......h..........sh...hsh..thhhChahh..........................................................t.C....t.t.hh..............................hl.slP...hhRhh.QClRc...ahc.s.tph..........................aLhNuhKYssshhhh....hhtsh....hph........t.t..t............................hhhhalhhshlsohYshhWDlhhDWuL..........................hp......s..................................................................................................................pthhLR......cplhh.................................p........h.hYYhuh...l.sllLRhsWhhp.h.h...................ph..h.....ps....phhs.hh...huhlElhR.RhhWsaaRlEsEal.............................................	0	185	336	476
+352	PF04554	Extensin_2		Extensin-like region	Bateman A	anon	Pfam-B_1707 (release 7.5)	Family	\N	20.80	20.80	21.10	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-11.10	0.72	-4.10	14	490	2009-01-15 18:05:59	2003-04-07 12:59:11	8	22	25	0	352	530	3	49.70	73	84.32	CHANGED	YcYpS.PPPP.hp........PPPP...Ya.......Y+SPPPP...s....YhYpS.PPP..Pha..........SPPPP.........YhYpSPPPP	................YlYsS.P.PPPhYp......Po..P+..spYKSPPPP.........Y...VYuS.PPP.......PhY.........SPSPp.........spYKSPPPP......................	0	227	309	310
+353	PF00646	F-box		F-box domain	Bateman A	anon	Prosite	Domain	This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07723) and the WD repeat (Pfam:PF00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression [3].	20.50	15.60	20.50	15.60	20.40	15.50	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.28	0.72	-4.22	463	9939	2012-10-02 00:56:31	2003-04-07 12:59:11	28	388	416	10	7006	15392	101	45.20	20	10.27	CHANGED	htl.pLPtc........................llppllpplshts.........hhphphls+phcphlpphphhtptht	...........................................................................h.pLPt-..........................................................lltcIl.p..p.L..s.hps..............................lh.p.hp..tls+pac.plhpp.........hh........................	0	1706	3015	5562
+354	PF00754	F5_F8_type_C		F5/8 type C domain	Bateman A, Finn RD	anon	Pfam-B_478 (release 2.1)	Domain	This domain is also known as the discoidin (DS) domain family [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.67	0.71	-4.31	185	10300	2012-10-03 19:46:52	2003-04-07 12:59:11	20	1197	1614	169	3934	9293	615	125.60	16	18.56	CHANGED	phsuSo..phssth............stttlD...ss............t.stWps....t.......sssspalpl..DL.spstplsslhhpst..psttt...........hspsaplphS..sDG.....p.........sWpphtt................ss.ssss.hh..........hh.sshpu.....RalRlhsh...........h.stsphsthhEl	.....................................................................s.....t.................tttl.D....us............................s.s..t..W.ps......t.........................sstspa.l..pl.................D.........L....s...p.......p.....p....l.s..t.l..t...h...p...sp....tsttt........................hspsa..p.l.t..hS........s..cu.........p..................sW.pphtp.........................................ss..s..s..s.s..hh........................................hh....t.s.h.p.u..............+a..l..Rlh.h................tt....h.............................................................................................	0	2052	2661	3306
+355	PF00487	FA_desaturase		Fatty acid desaturase	Finn RD, Bateman A	anon	Bateman A	Domain	\N	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.16	0.70	-4.94	127	9036	2009-01-15 18:05:59	2003-04-07 12:59:11	19	46	2567	0	3138	8639	3621	228.30	15	66.62	CHANGED	hs.hhhhhhhhhhhshhhthhhhltH-ssHt.....thhtpphhsphhuthhshh....hhhshht.a...p.......Hhh.HH......phhss.t........Dssthhh..............................hhhhtphhhhhhhthhhhhhhhhhthtttthhttthh........................................hhhhhhhshhhhhhhh.hhhhhhht..................shhhhhhshhhhhhhhhhhs...........h.t..Hhhh...........tttttstshhtpp....hh............hhshhhhs..hs.aHh..................tHHh...aP...sls....ahpLsphttthtphhtttthshhtht	...................................................................................................hh.h.h.h.h..h.h..h..h.hh.t...hhh..hh.tHphuHt......................th....t..p....t.....h..h..p..p..h.h..u.h.h..hhhh.........................h.sshht..a...thp...........................Hpt.HH......................phsss.t...............Dss.shh............................................................................t...t..h....h..h.....t..h..h.h...h....h......h...h..h....h...h..h..h..h......h.....t...h..t..h....t.p....h..t..phtt................................................................h...h.hh.hhh.hh..h...h....s.h..h...hh........hh...h...h.........h...h...t........................................................hh...h..h....h..h....l.......t..h..h.....h...h.t.h.h.h.hhs.........................ht.......Hhh.............................h.tpttpthhp.pt................h...........................t..h.h.h....s..h..h.hh..s........hs..hHs...................H...Hh..........aP............th........h..h........................t...........................................................................................................	0	1025	1826	2610
+356	PF02913	FAD-oxidase_C		FAD linked oxidases, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	This domain has a ferredoxin-like fold.	21.20	13.90	21.20	13.90	21.10	13.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.30	0.70	-5.06	62	9445	2012-10-02 00:48:38	2003-04-07 12:59:11	14	65	3272	53	2996	8280	3740	227.50	22	39.33	CHANGED	hPpttssshshasshpsAs..psstplhpp.thhssshEhhDptshphshshhsh.........................tt.shlllchpusp...th.tpphp..tltphhptsssss................hhsps.tphp..plWp...hR+thhs.............hhhpttshsht.DsslPhsclsshlpphcphhsphs..........hhhshhuHsG.......DGNlHhhlhhs.ts......tthcphpphhtcl....hthshphGGolouEHGlGht+pt....ahttthuttslshh+plKpshDPpsILNPG+l	.......................................................................................................................................................................Pt.ttshhhta..s..s.......hpsAh.....psl...t.h....h....t..........t.....t.............h..s....s..u..hE......hhDph....s.l.p..hs.pph.hth......................................................h.p.t..t.s..h.ll.lE...h.s...G.s.s.............t..t.h.....p.........p.......p........hp................hltph.hp..p.t.s..s.t.p............................................h.......hsps.tptp.........plWt.........hRcpshs..........................................h...t...p...h...t...s..hhh.t..p...Ds..slPh..spl.sphlpp..h.pthhp.phs...............................................ht.h.s..hhuHsG.............DGN..l.Hh..h..l..h....h...s..h..s..p......................tp..h..p..p.h....c..t..h.h.p.cl...........hp.h.s.h.c.h.G.Go.l....o...u.EHG..lGht+.t.........hh.h........h..u..ttt.......h.thh.ctlKtshDPpslhNPGK.........................................................................	0	916	1869	2506
+357	PF01565	FAD_binding_4		FAD binding domain 	Bashton M, Bateman A	anon	Pfam-B_352 (release 4.0)	Domain	This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110 [1]. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyses the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyses the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158.  This enzyme is involved in the biosynthesis of peptidoglycan [2].	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.52	0.71	-4.70	142	20637	2012-10-02 01:00:47	2003-04-07 12:59:11	18	164	4917	139	7390	17693	6472	133.60	21	26.34	CHANGED	P.thllhPpotp-ltphlchup..pp...shs..lhshGuGsshs.uts..........psu...lllsh.t..p.hsp..lhpl-s....t...stpsplpuGshhtpltptlttp..uhhhs.p.sush.ss..olGGhlsssusGhtstta.G.hh..-hlhulcllh.ssGpllphu	.........................................................hllhPpsh.p-ltth..........l....ph.st.............pp..................p..h.s.........l..h...s...h.G.u.G........o.s...hh..utsh.................tsu.................ll..l.sh..p...........p..hsp...........l..h.p...l..c...............................t...........s..t..h..l..p...l..p..u.....G.s.h.h.t..p............l.t.p..t.........h......t........t....p...........u...h..h..h......s................p....s............u....s...t....................s............s........o........l.G...G.s...l..s.s...........s...u...u.......G...h..t..........s...h.........t..........h...G.....hh......-h..lhs.l....cl..lh..ss..Gplhph.................................................................	0	2058	4492	6188
+358	PF00970	FAD_binding_6	Cyt_reductase; 	Oxidoreductase FAD-binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_143 (release 3.0)	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.35	0.72	-3.87	115	14779	2012-10-03 00:38:56	2003-04-07 12:59:11	19	159	4278	144	4286	11998	1730	96.10	21	26.84	CHANGED	tspLls+pplScDs+hF+F.tL..s.sssph...luL..PsGpalhlpss...ls.sc.hhRuYoPsSss..s..-hGh..h-LllKlY.........sGGtMSp.aL.-s.L.plGsh.lcl+GPhGp.htY	...............................................................................lhphp...s..t..s..h.h..h.....hp..h..th...........s....t..........t....t..........h..t.a......p.s.G....Q...a......l..t.........l...t...l...........t.................p.......s............p.........................h........h............R.s....Y.........S........h......s.................s.......s................s........s.............pp.s...t...............lc......l..tl...+t.h............................s..G.h....h..S..s....h...L....p.....p.....l.....p.......s...G.......D.....p......l.p....l.t.s....PhGp.h..h...................................................	1	1115	2425	3487
+359	PF03441	FAD_binding_7		FAD binding domain of DNA photolyase	Griffiths-Jones SR	anon	SCOP	Domain	\N	20.10	20.10	20.10	20.10	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.86	0.70	-5.19	163	4493	2009-09-11 23:21:46	2003-04-07 12:59:11	9	22	2644	55	1440	3950	7444	245.00	30	51.07	CHANGED	sGEps..AhppL....psFl..p..p..plpsYpps..Rsh.P......ut.....s.........................................uoSpLSPaLpaGplSsRplhptspptt...........................shpsalpcL.hWR-a.hhphhhptPpht.....................t.shppta.ps.h...Wt..................ts.p...tthpsWppGcTGaPllDAuMRpLhpTGa..hHNRhRhhsuSFLsK.cLhl-WctGtc.....................aF...........hppLlDh-.usN.ssWQa.uu.sGhss...hRlaNPhpQuc+aDPsGpal+pWlPELtslssc.hl..Hp...........................Paphst......................s.......YPp.P..ll-hppsRctslctatphp	......................................................................................ucptAhppL.....ppFh.p............ptl.t.pY.ppt..Rsh...s.......sh....s..........................................uo....Sp....LSsaLt............h...G..tlS.sR..phhpplhpttt.......t................................................tsspsa.lpcL..hWR.EF.ah.tl.h.h.t.h.P.p.h.t............................................................................p.ts...h.ps..t..h..pp..h......W........................................s..tthpt..W...p.p...GcTGaPll.D.Au.....MRp.LhpTG.a..hHNRhR.h...h........s.A.oFLsK..cLh..l...cW.c...G..t..c.....................aF.......................hppLlD.h....Dh...us...N......ssW....Q......ahuu....s...G..............s..D....s.........h..............h....R.h.aNP..............h..t.Q.........u.c.+a.....DspGp..a...l..+.p.....al.PpL.tt...lss......p......l.ap.............................................sht...........................................................t..............YP..s..hl.phtttp...hthh....t...................................................................................................	0	488	923	1231
+360	PF03101	FAR1		FAR1 DNA-binding domain	Mifsud W, Bateman A	anon	Pfam-B_2535 (release 6.4)	Domain	This domain contains a WRKY like fold and is therefore most likely a zinc binding DNA-binding domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.27	0.72	-3.46	43	1076	2012-10-02 23:28:20	2003-04-07 12:59:11	10	54	116	0	699	1040	0	87.40	24	15.96	CHANGED	pFYspYAtpsGFulRhsppp+o...ptss.hhpppFsCs+pGhppppppp.............................ptpp.....sps.oRsGCcAtltl+hpp...sucWhVsphs.....h-HNHtLss	.....................................................aYptYAtphGFsl+hpp.s..p.ps........ts.t..t..hh..ppp..a.s...C..s..+pGhppppptp.....................................................t..pp............pspsR.suC..pA.h.h.t.l..p...hpt.........ss......p..W...hl....p.p.h...........hcHNH.l.............................................	0	82	399	567
+361	PF04300	FBA		F-box associated region	Bateman A	anon	Bateman A	Family	Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Swiss:Q9UK22 is involved in binding to N-glycosylated proteins.	25.00	25.00	27.50	25.90	21.50	23.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.36	0.71	-4.32	6	396	2012-10-03 19:46:52	2003-04-07 12:59:11	8	16	84	7	192	352	2	158.30	36	59.10	CHANGED	WKshYhhpshcRNLLRNPCu.............................EtshpuWp.lp.pGGDtWpVEpLPhssusphP.sstVpphFloSFcWCpKpQhVDLcAEGhW-ELLDoFpP-IVVcDWausRtDsGChYpLcVpLLuAD.psVLspFossPssh.Qhss.ssWpcVSHsFScYsPGVRalpFpHtGpDTQFWsGaaGsRVTNSSVlVcs	.................................................................p.hh...h...hp.htRNLl+NP...su...........................................................................-.p.sh..phWp...lp..pG..G..s.tWtlEp....t.......p....t....t.hs...s...........tl..........p....ph.Fl.o.S.athChKp.Qll....DL.tEG.h....htclh.DphpPcIh...lpDW.as.s...Rt..ssus.h.Yp.lpVpLL...........stp...p.....ps.............l..............sp..........F...............p......ss..........................h...h.ph.ss.......tt....WpploHsFpsYs.sGVRalhFpHtGp..Dsp.aWtGaaGs+lTsSSl.l..h..........................	0	32	57	98
+362	PF00611	FCH		Fes/CIP4, and EFC/F-BAR homology domain	Ponting C, Schultz J, Bork P	anon	SMART	Family	Alignment extended from [1]. Highly alpha-helical.  The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins [2]. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localise to actin-rich structures [3].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.07	0.72	-3.80	157	2299	2009-11-12 14:53:54	2003-04-07 12:59:11	18	60	270	55	1342	2138	1	91.60	21	13.78	CHANGED	psFhsph.........tuhcslhp+hcpuhphh.c-ltpah.+cRuplEccYuppLp.clspchhptht.........ttpp......uol.................ppuapplhspscphuptHtphuppl	..............................hhtth.............tthcsL.pphppuhp.hh.c......-l...tpah.+c.Ru..plEcpYup....p.....Lp...cLucchtttht...................sppp.............soh......................................................tpuapslh.sp.scphuptHtplupph........................................................................................................	0	361	566	953
+363	PF00111	Fer2	fer2; 	2Fe-2S iron-sulfur cluster binding domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	15.00	20.70	15.40	20.60	14.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.55	0.72	-4.23	206	17474	2012-10-02 17:47:23	2003-04-07 12:59:11	22	166	3695	266	5439	17310	7619	75.20	21	24.22	CHANGED	hphpup..thphpsssspp.lLcshc...p.t.slslshuCps.......Gs....CusCtsplhtu.................hpspphttt.h.....................LuCtshsp	.......................................h....sp...th.pl...p..s..s..s..s..p.s.....lLcshc.............p...t..........s....l...s......l......t......h.......uCpt................................Gs..C.Gs..Cp..lh.lh..p.Gps.........p...................ptp......t........................................................LsC.sh.........................................................................................	0	1464	3188	4405
+364	PF01799	Fer2_2	fer2_2; 	[2Fe-2S] binding domain	Bateman A	anon	Bateman A	Domain	\N	20.90	20.90	21.20	21.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.77	0.72	-4.08	157	5947	2012-10-02 17:47:23	2003-04-07 12:59:11	15	71	2180	114	2017	5159	1915	75.40	40	17.35	CHANGED	TlE..GL..............s.p..ssplcslQpAFl-ppuhQCGaCTPGhlhuutuLLc...p..................ps.ps......occ-.lccu.l.sG..NLCRCTGYppIlcAlpp	.............................................TlEGL.....................s.p.ssp.l..cslQpAahcp......pusQ..CGa.C.TPGhlMoshu.LLcp............................................ss...pP.............ocp-..I.c.cu.l..u.G.....N..LCRCTGYptIlpAlp.t.........................	0	620	1185	1606
+365	PF04324	Fer2_BFD	fer2_BFD; 	BFD-like [2Fe-2S] binding domain	Kerrison ND, Finn RD	anon	COG2906	Domain	The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD, Swiss:P13655).  The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria [1].  This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (Pfam:PF01077), Nitrite/Sulfite reductase ferredoxin-like half domain (Pfam:PF03460) and Pyridine nucleotide-disulphide oxidoreductase (Pfam:PF00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (Pfam:PF01592) and NifU-like domain (Pfam:PF01106).	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.09	0.72	-3.91	190	6775	2009-01-15 18:05:59	2003-04-07 12:59:11	10	90	2902	2	1800	5000	364	54.70	27	11.81	CHANGED	thl..CtCpsVoctplppsl.....................tp.............hp...s.....hpplpptsts.............GssCG.sChs....ht......pllpptt	...................hlCpCpsVocupItpAl.....................tp..............tuspo.......lppl+ppTcs.........................Gss.CG...sChs..........ht....plltt..t...............................	0	527	1115	1483
+366	PF00037	Fer4	fer4; 	4Fe-4S binding domain	Bateman A, Eddy SR	anon	Prosite	Domain	Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.61	0.73	-7.60	0.73	-4.16	533	8206	2012-10-03 08:56:42	2003-04-07 12:59:11	22	662	2969	164	3310	39684	11065	23.50	39	7.69	CHANGED	hhlstcpChsCGtChpsCPssAlp	......h..ls.ccClsCGhChpsCPhsAI........	0	1442	2410	2918
+367	PF00210	Ferritin	ferritin; 	Ferritin-like domain	Finn RD, Bateman A	anon	Prosite	Domain	This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.60	0.71	-4.43	243	10640	2012-10-01 21:25:29	2003-04-07 12:59:11	19	13	4559	1610	2459	7325	1350	137.80	20	82.92	CHANGED	hptLNctlstE...htushtYhthuhhhc..shshtshsphhcppupEEh.pHApclh-hlhthG........G.....ph.......phhp...........h.................................s.ssh-hlctslptEpplspplpclhphup....pp......p..DhsotshL.pthlp-.p.cchthlpshlppl..cth	...........................................phLNctl...spp...hhuhh.hYhph........phhhc......shsh..slt..phh..cc.........ps.p-ph...p.....Hs.......-cl.h.-+lh..p..lG............u.....s...hphh...........thhp..........................h.....p..........................................................hs.ssp-h.lc...p...s...lp...t...p..p.t.l.s...........p.pl.p...c.h.h.p.h.up......pt................p..D......sotshl.pth.l.p-.pccphhhlpshlp................................................................................................	0	681	1367	1912
+368	PF01839	FG-GAP		FG-GAP repeat	Bateman A	anon	[1]	Repeat	This family contains the extracellular repeat that is found in up to seven copies in alpha integrins.  This repeat has been predicted to fold into a beta propeller structure [1]. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat [1].  The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding [2]. A putative Ca2+ binding motif is found in some of the repeats.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.94	0.72	-4.16	470	2456	2012-10-05 17:30:42	2003-04-07 12:59:11	18	220	351	67	1119	4198	1515	38.40	33	6.96	CHANGED	hstslssu..DlsGDGhsDlll..........................ssts....stlhlh	............Ghulusu..DlNGDGhsDlllG.....................................stptp......GtlYl.....................................	0	347	596	821
+369	PF02181	FH2		Formin Homology 2 Domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	25.20	25.20	25.20	25.20	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.25	0.70	-5.57	48	2361	2009-01-15 18:05:59	2003-04-07 12:59:11	18	102	317	21	1446	2150	30	329.40	23	32.57	CHANGED	tppt.psct+LKsLpWsKl..............................p.ssp.ps...........lWsclpppp..............ph-ht-h-thFsststpthtpt............................sstpppspclplLDs++upNluIhLppl..phshc-lhpulhph-p.phLs.............h-hl-pLh.chhPsc-Ehptl..p........phps-......hppLucsE...pFlhplsp.lsthppRlpshhFptsFpsplpplptplpslppAscpL+pScphpplLchlLthGNaMNsGst..GsAhGF+LsoLhKLsDsKus.-s+pT..LLHalsphltc.............................................phsclhshs.s-LpslccAuplsh-slppslppLpcslpplcpplptttp.......t.tptFhphhppFlppucpclcplpsthppshpthcchscYa...spssp....phs.pphFshlppFlphac	..................................................................................................................................h.....tsphth.h.h.W..pp..l....................................................................tp.h..pt.......................lW..sp......hp...ptt..........................................t.ph..t..c..hpthFttpttt...t...........................................................................t.tppp.pplpl..............L.-s.++upN.............ls.I..hL.p........p......h......p........h.s..........cc........l.t.....p...s...l..h..p..h..-p....ph..ls.............................................h-hl..p..p..Lh..phhP.p.p..cEh.phl.......p..........................ph...ptp..............hppLsps-..pFh.ht...h................p..ls.....php...t.....R.l.pshha.p......hpFpp...........p..h.p.p.lp....p..........lp..s.............ltt.Asp...p.......l.....p...pS....p.....p....hpp..lLp......h....lLthGNah..N....s..u..........p..................up....A.......hGF.c.L.s........L.+........L......t-.....s....Kus....c........p.p...........h...o......LLHal..s.ph.h.tp....................................................................................................................p.h.s..p..h..h..p.....h.........s-l..........ttl....p..p..A.u...p............l..s.hc.p.ltpp.............lppl.ppt.hpt.hpp.plph.tp.........................................h.....hp.h.h...........p......pFlpp...sp.tphp...tlpt..hp...p............h............p....hhpp..hhtaa..............s.ssp..........ph.p...p.phFthhtpFht.a.......................................................................................................	0	487	743	1102
+370	PF02661	Fic		Fic/DOC family	Bashton M, Bateman A	anon	COG2184 & COG3654	Family	This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing).  The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism [1].  This family contains a central conserved motif HPFXXGNG in most members.  The exact molecular function of these proteins is uncertain.  P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation [1].  A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1 [2]. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family [2]. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc [3].This domain forms complexes with Phd antitoxins containing Pfam:PF02604.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.65	0.72	-3.29	221	6829	2009-01-15 18:05:59	2003-04-07 12:59:11	13	61	3371	61	1631	5456	731	97.70	21	34.91	CHANGED	hls...hptlhp.lHp.tl......hppht............................Gth......Rs..h...................shhptshspsp.ph.thh..........thhs....................hhptuAth.thtlsphHPFhDGNtRsuthhhthhL	......................................................................................................................................p.t.lhplHp..hl..........hp.t.hht........................s................................Gph.........Rp.th...........................................................t.thp.h...h.h.s.t.st...pl..t.t.h............pphhphhp...................t..p...................htphu..hh.ahph.ttlHPFtDGNGRsuRhhhthhL..................................	0	529	1058	1363
+371	PF00254	FKBP_C	FKBP; 	FKBP-type peptidyl-prolyl cis-trans isomerase	Finn RD	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.95	0.72	-3.97	174	16739	2009-01-15 18:05:59	2003-04-07 12:59:11	23	143	5125	202	5251	12394	3280	99.80	27	37.70	CHANGED	ssp.sppGD.pV......plcYpGpl.........s...Gph..........FDuo..........h........+spshpaplGp...sp...VIp......................Ga-pulhs...........MpsG-ctplhlss.phuYGp......................................puh.s.......IPss.........................usLhF-V-Ll	..........................................................................................................................................................tt....sppsc..tV.......plcYp.G.pl....................D.........Gph..................................F.Duo..........................................................................pups.h..s...a....h.l.....G..t.............sp....lIs...........................................................G.a...-cul..hu.........................h.p....sG...-.c..h.p.l.h.ls...s...p..........u..YGt...........................................................................psh....s.................st.................................................pslhFclcl.....................................................................................................................................................................	0	1593	3021	4223
+372	PF01003	Flavi_capsid		Flavivirus capsid protein C	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)  	Family	Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E.  Multiple copies of the C protein  form the nucleocapsid, which contains the ssRNA molecule.	21.00	21.00	21.60	24.90	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.64	0.71	-4.55	27	4730	2009-01-15 18:05:59	2003-04-07 12:59:11	14	17	108	12	0	4102	0	108.70	56	4.51	CHANGED	ts.ups+slNMLKRshscs...httsKRhhhsLhsG.GPhRhVLAhlsFh+...FsulsPTsuLhpRW+sVsKppAh+tLpsFKK-lGshlssl.s+Rt++.tth.s.sshlLhl....hhlshshA	..................................KKstpsshNMLKRsRNRVSTspQLsKRFSh.GLLsGpGPh.KLVMAhlAFLR...FLAIPPTAGlLsRWGohKKssAIKVL+GFKKEIusMLsIlNRR++o.........shhLlMl....hsss..hhhh..............	1	0	0	0
+373	PF02832	Flavi_glycop_C		Flavivirus glycoprotein, immunoglobulin-like domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_146 (release 3.0)	Domain	\N	20.80	20.80	21.00	20.80	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.32	0.72	-4.10	12	9726	2009-01-15 18:05:59	2003-04-07 12:59:11	11	26	131	56	0	6580	0	95.50	58	6.56	CHANGED	oYsMCss.KFpapKsPuDTGHGTVVlcVpYoGssuPC+IPlpsssphpshssVGRLlTsNPhlsss..putVhIEhEPPFGDSYIlVGhGpppLshpWa+	..SYuMCTs.pFKlhKEsAETQHGTlVlclpYcGsDuPCKIPhsshD.hpshsslGRLITsNPlVosp..-ssVNIEsEPPFGDSYIVlGhG-ptLplpWaK.............	0	0	0	0
+374	PF00869	Flavi_glycoprot		Flavivirus glycoprotein, central and dimerisation domains	Bateman A, Griffiths-Jones SR	anon	Pfam-B_146 (release 3.0)	Domain	\N	20.00	20.00	20.60	20.20	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.83	0.70	-5.43	35	10895	2012-10-01 19:42:26	2003-04-07 12:59:11	15	32	141	36	1	7165	0	269.90	59	20.34	CHANGED	h+ClulpNRDFlcGsoGsTWVslVLEpGuCVTlhAcsKPolDlhLsshptps.AtsRcYChcAploshpssuRCPThGEApLsEEpsssaVCKRsaoDRGWGNGCGLFGKGSIVsCAKFoC...scphpGhhlptpplpYsVtlpVHsupttsstt......ssspttphphTspusppshsLu-Y..GplolsCcspSGlDhsphhlhpls......s+sWhVHR-WFpDLsLPWp.....tsusss...Wcsp-pLV-FcpPHAsK.sVhsLGsQEGulhpALuGAh.lphsusp...hpLpu.............GHlpC+lph-KL+lKG	.......................................+ClGluNRDFVEGlSGuTWVDlVLEtGSCVTsMAKsKPTLDlcLhphEApp.AplRchClcAploshoTsuRCPTpGEApLsEEpDtsaVC++shVDRGWGNGCGLFGKGS.llTCAKFpC...tpphpG+llQhENlcYoVhlpVHoG-pptsss.......ssppusphpITPpusosphpLs-Y..GslTl-CpPRoGLDhNphllLphc......sKuWLVHRpWFhDLsLPWo.....uuusTp...Wpp+EhLVpFcssHApKQ-VVsLGSQEGAhHoALsGAs.lph..Suss.....plhu.............GHLKCRl+MDKLpLKG.......................................................................................	1	1	1	1
+375	PF00949	Peptidase_S7	Flavi_helicase; 	Peptidase S7, Flavivirus NS3 serine protease 	Finn RD	anon	Pfam-B_199 (release 3.0)	Family	The viral genome is a positive strand RNA that encodes a single  polyprotein precursor. Processing of the polyprotein precursor into mature proteins is carried out by the host signal peptidase and by NS3 serine  protease, which requires NS2B (Pfam:PF01002) as a cofactor [4]. 	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.50	0.71	-4.75	50	3378	2012-10-02 13:45:52	2003-04-07 12:59:11	16	23	150	15	17	3915	116	149.10	68	4.59	CHANGED	hc.lpsGVY..RIhptulh.GppQ.......hGVGhhppGVhHTMWHVTRGAsLph...sstthsPtWus....V+cDllsYGGsWcLpt+WcG.c-VQlhAh.Pst.hp.hQspPGhhph.tG.plGAlslDaPsGTSGSPIl...NppGcllGLYGNGlhhs......ssYlSuIuQu	..............................................................................................................................................................................u.-L--GlYRIhQRGlL.GpoQ.......lGsGVhpEGVFHTMWHVTRGAVLMa...pGKRL.....EPsWAS....VKKDLISY...G...G.G.W+....Lp...up...Wpp.GEEVQVIAVEPGKNPKNV..............................................................................QTtPGsFKTspG.....E.....l...G.....A.l..u..L.D..F.pPGTSGSPIl...sR.cGKVVG.L.YGNGVVTp.....sGsYVSAIAQs......................	0	13	14	14
+376	PF01004	Flavi_M		Flavivirus envelope glycoprotein M	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)  	Family	Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.	21.20	10.00	21.30	20.40	20.60	9.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.50	0.72	-4.55	30	4840	2009-01-15 18:05:59	2003-04-07 12:59:11	14	26	115	0	0	4095	1	71.00	55	2.92	CHANGED	SVslssHsppsLssRsp.sWhcucpspcaLs+VEsWllRNPsaAlssssluWhlGsohsQRlllhlhlLLlAPAYu	.......SVALsPHsGhGL-TRsp.TWMSSEGAW+plp+lEoWhLRpPGFsllAhhLAahIGoohhQR.slIFILLhLVuPSh....	0	0	0	0
+377	PF00948	Flavi_NS1		Flavivirus non-structural Protein NS1 	Finn RD, Bateman A	anon	Pfam-B_157 (release 3.0)	Family	The NS1 protein is well conserved amongst the flaviviruses. It contains 12 cysteines, and undergoes glycosylation in a similar manner to other NS proteins.  Mutational analysis has strongly  implied a role for NS1 in the early stages of RNA replication.	19.90	19.90	19.90	20.40	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.14	0.70	-6.04	11	4700	2009-09-11 01:25:55	2003-04-07 12:59:11	16	26	120	0	1	3925	0	270.30	70	11.15	CHANGED	hGCAIDhpR+EL+CGuGIFVas-VcsWh-pYKYhPEoPppLApslpcAac-Gl...CGlRSssRLEptMW+ultsELNhlLpENplcLoVVVscscshhppu..s+sLphpsc-LchuWKoWGKuhlaus-huNsoFllDGPpTpE..........CPsppRAWN.....sacVEDFGFGlhoT+laLclREcsTpECDotlhGsAVKss+AVHoDhoYWIES.phNsTWplE+A.htEVKsCoWPcoHTLWu.sGVlES-hlIPhoLAGPhSpHN+RsGY+TQspGPWcpsclclDF-aCPGTTVslsEcCspRGsSlRTTTsSGKLIs-WCCRSCTLPPLRFpspsGCWYGMEIRPl+ccEssLV+ShVsAssGp	................oGCVIsWKs+ELKCGSGIFVTN-VHTWTEQYKFQs.-SP.p+.L.As.uItpAa..c..-Gl...CGlRSsoRLEphMWcplpsELNhlL.EN.thchol..h..s..sc...G.hhttu...+.lpsps.chchuWKsWGKuh......hh......ss-.t..NpoFllDGPpT.E...............CPstpRAWN................hEVEDaGFGlhoTplaLKlR-t.s..CDp+lhusAlKsphAVHuDhuYWIES..th..Nto.WKlt+AshhEVKoChWPcoHTLWu.sGVLES-hIIPt.huGPhSpHNhRPGYhTQstGPWc..G+lEhDFshC.GTTVslsEpCGpRGPSlRTTTsoGKlIp-WCCRSC...TLPPLRahs-sGCWYGMEIRPhpccE.cshVpS.VsAhpu.p................	0	0	0	1
+378	PF01005	Flavi_NS2A		Flavivirus non-structural protein NS2A	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)	Family	NS2A is a hydrophobic protein about 25 kDa is size.  NS2A is  cleaved from NS1 by a membrane bound host protease [2].  NS2A has been found to associate with the dsRNA within the vesicle packages.  It has also been found that NS2A associates with the  known replicase components and so NS2A has been postulated to be part of this replicase complex [1]. 	25.10	25.10	25.20	40.20	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.28	0.70	-5.05	37	3339	2009-01-15 18:05:59	2003-04-07 12:59:11	14	19	108	0	0	3344	0	208.40	46	6.38	CHANGED	Gllslhlshp.llR+Rh..Tu+thlhuulhlLslhlhGhlThpDLhRYllhVGhsFst.psGs-lhaLsLl.AsFclRsuhLsuahLRppaTsREslllhluhshlphuhst....h.hslhphhculAluhhll+Ahsptppssluh.llulhs.tthhhlhtuhphhlhllsssulhp.t+ssst+.Kshshllslu.....lhus.Ghh..hlshhtlhhtps.t+.R	................GlLslulhhEEVhRsRa..upKhhhsullssFllLlhGplTapDLhRhsIMVGAshoD.chGMGlTYLALh.ATFKlpPhFAlGhhLR.+LTS+EslLLslGluhhspsp......LPpsl.-lsDuLAlGhMlLKllTphpsaQLhssLluLossssthhLpsAW+shshlLulVSLhPLph.oootQ.Ks.s.WlP.lsLu.....hhGs.....sPlshFlhshs+s.p+R...............	0	0	0	0
+379	PF01002	Flavi_NS2B		Flavivirus non-structural protein NS2B	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)	Family	Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. All, but two, are cleaved by the NS2B-NS3 protease complex.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.29	0.71	-4.55	30	3263	2009-01-15 18:05:59	2003-04-07 12:59:11	14	18	115	15	2	3330	1	127.00	55	3.81	CHANGED	hoEslTAVGlhhsLsuulh+.sssphhsPhssuGllllsYlloG+sssLhlE+su-lpW-p-AphoGuSscLcVchDspGsh+Lh--ctsshphhlhhsshlshuAhaPhuIhhshsuWahhp...pss+R	......LNEulMAVGlVSILsSSLL+.NDlPMAGPLlAG..GLLhACYVIoGpSADLpLE+AADVoWE--AEhoGuScpl.VplsDDGoMpIKs-Ec-shLTlLL+ssLLslSGlaPhSIPsTlhsWahWp...pppQR...............................	0	0	0	2
+380	PF01613	Flavin_Reduct		Flavin reductase like domain	Bashton M, Bateman A	anon	Pfam-B_710 (release 4.1)	Domain	This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin [1]. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalysed by SnaA, SnaB heterodimer [2].  This flavin reductase region characterised by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain [1].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.19	0.71	-4.37	141	7912	2012-10-02 11:35:36	2003-04-07 12:59:11	13	38	3556	70	2331	6180	2131	151.60	19	73.61	CHANGED	htp..hsssVsllos.t........sspsh............G....hss.oshsslShc.P.Phlh.hsls.......pp...............................................................................spohshlpp...ssp............Fslsl....Lsp.sp.tp.lu....ptFus.......................tttc+..hs.shphpts.......................sus.......Phl..psuh.uthcC...clhp..p......hss.G.s............HslhlucVhsh...thtps..t.................Llahp.tpapshs	.................................................h.....hstslslloo..st.............suths..............................s.........hss.oh......h...s.s...l....sh..s....P..Ph....lh..l....s.ls...........pp................................................................................ppohth.lpp...ssp..........................Fslsl........lst...sp...t.....p..hs.............pthus..s................................................tt-+......h..s..slshttu.........................................sus..........................P.hl........pp.uh..sth-C..clhp....h..................hph...G.s.................................................................as.lhl..ucl..h.s.h........thssp......................................................h......................................................	0	675	1440	1926
+381	PF00258	Flavodoxin_1	flavodoxin; 	Flavodoxin	Finn RD	anon	Prosite	Domain	\N	24.40	23.20	24.40	23.20	24.30	23.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.84	0.71	-4.19	92	10556	2012-10-03 05:08:30	2003-04-07 12:59:11	20	121	3998	199	2717	8477	791	138.50	22	32.80	CHANGED	llYuSpoGsscphActlscthpt.tsh.spshshtphs.........tpl.ptthllhsssThstGpss.s.......h.phhthh.............................................................tt..htshphulhGhGspsatt.......attssptlcpplpp.hGuppls......................shsts-pps...shcpthptW	.....................................................................lhauS.p.o.Gssc.t....l....Ac.t...........l.t....ct.l............t..........t..................s............h...........p........s..........p........l....h...s..h.s...c.hs...........................tpl..t.p....t......c.....h...l..lls...s..u..T.a...G...p.G.-...hP.pp................h.h.c.hhp...h...........................................................................................tt...pL..s.s..h..p...hulh...G.h....G...D..psatt..................FstuscplcptLpp.hG.u.p.h.ls............................ttlth.D....p....t.......ct..........................................................................................................................	0	813	1530	2194
+382	PF04500	FLYWCH		FLYWCH zinc finger domain	Krauss V, Dorn R	anon	Krauss V	Domain	Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.26	0.72	-4.08	128	1130	2012-10-02 23:28:20	2003-04-07 12:59:11	11	45	72	1	775	1222	0	60.70	23	26.35	CHANGED	ahpop+.Gpth...LlhsGahatpsppp.....s.sptaWcC.sphpp......hpC+ARlhTp.....sspplhhhp.s....HNH	..............hhstp.Gt.h....L.l.hp.u.ahYptpppt.............s.sphhWpC.spppp...........pC+u+lhTp.............stplhhhp..t......HsH..................	0	187	296	645
+383	PF03358	FMN_red		NADPH-dependent FMN reductase	Mifsud W	anon	Pfam-B_2010 (release 6.6)	Family	\N	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.81	0.71	-4.71	276	11795	2012-10-03 05:08:30	2003-04-07 12:59:11	10	50	3935	96	3325	13002	2408	145.70	18	69.81	CHANGED	h+llsl.sGSs........R.......ps......uhsptlsphstp......hh.....t.........t.h-s...............cll.-....lsch..hP.....hhstch.............ssts.....pphtppltpAD..ulllsoPEYssuhsusLKshlDhhs........................tpthp.sKss...............uhl..ususu.tGuhpshtpL+thhs....hpshslss.thslstshp	.........................................................................................plhhl...G..S....p...................tt.......u..h.sptl.s..p..h..htc...................th......tt..................................s..h-s..........................phh...p...........lsch......hs.............................hh.s.tsh.................................tssh...................tt.h....h....p..p......l.t.p.AD...ullhuoPpYht...uhs..........usl..Kshl.D.h.hs...................................h.tpsht...sK.ss........................................s.lh........ss.u..s....s..........t..u.......s...........p...s.........h...p...h.t..h.h...h...hth.hhh.s............t............................................................................................	0	1024	2182	2831
+384	PF02434	Fringe		Fringe-like	Mian N, Bateman A	anon	Pfam-B_1900 (release 5.4)	Family	The drosophila protein fringe (FNG) is a  glucosaminyltransferase that controls the response of the Notch receptor to specific ligands [2]. FNG is localised to the Golgi apparatus [1] (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homologue, lunatic fringe, has been implicated in a variety of functions.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.81	0.70	-5.17	27	1045	2012-10-03 05:28:31	2003-04-07 12:59:11	11	26	186	2	715	1675	8	183.50	22	50.40	CHANGED	p.hphcD..lFIAVKTT+KaHcsRlsllhcTWhspA+cQTahFTDs-DppLppp.....hs.pllsTNCSssHsRps.........LsCKhuspaDpFlpSsp....+WaCHVDDDNYlNlspLlcLLssYshopDlYlG+PSls+Plpshct.............................p.spFWFA.......TGGA..........GFCl..................SRuLALKM..........P..aAStuphhssuctlphPDDCTlGaIlpshLslplh+osLFHSHLEsLtplsspplpcQV............................olSYuth....sphNhlphtts...Fs.ppDPoR	............................................................................................................h..........................ph.......l....t..TW.t.h..................................h....................o.....s.........................p..t....h...................................h.........t.....tt....................t..............................h.t.h....h........h......h...t..h...h...h..p..s..pt................cWahhsDDDT.Y.l.....hpsLh.p...hL.....p......s......a....s.....s..s....p...s...l.Y.lG...p.............h......s.h...h.pt.........................................................a.h.........sGGA.........................Gasl..................S+t.hhp+.h........................hh.p.t.t..p....h....p....s..t....................-....Dh......h.Ghhhtt...hth....................................................................................................................................................................................................................................................	0	208	292	533
+385	PF01534	Frizzled		Frizzled/Smoothened family membrane region	Bateman A	anon	Pfam-B_949 (release 4.0)	Family	This family contains the membrane spanning region of frizzled and smoothened receptors.  This membrane region is predicted to contain seven transmembrane alpha helices.  Proteins related to Drosophila frizzled (Swiss:P18537) are receptors for Wnt (mediating the beta-catenin signalling pathway) [1], but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding [2].  The smoothened receptor mediates hedgehog signalling [3].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.19	0.70	-5.65	11	1043	2012-10-03 04:04:29	2003-04-07 12:59:11	12	9	159	0	557	939	0	269.20	38	53.08	CHANGED	saFop-E+pFschWIGlWSslChhSTLFTVhTFLIDhc.RF+YPERPIIFLSsCYhhVSluallphhst.c-cluCst.....................................tttttpplp.sohpspuCTllFlLlYFFsMAuSlWWVILolTWFLAAGhKWG.pEAI-t+upYFHLuAWulPulpTIslLAlupVDGDsloGlCaVG.hshcuLpGFVLuPLslYLllGshFLLAGhVSLF+IRolhpppG.....spo-KLEKLMlRIGlFSlLYhVPAslVluCYhYEttptspWthshhsp.Ctphp...s.s.t....s...t+Pp.hsVhMlKYhMsLlVGITSusWlWSuKTlpoW+pahpRhps+	............................................................happp-hphs.phaluhhuhl.C.h.huThFT..l.hTF.Ll...Dhp...R....Fp....Y.P..ERPIlaluhCY.h.hSlua...lhthhh.....tcplsCst................................................................................t.t.t.....p...h...l..h.....t......s.....p..stuCsllFhllYaFsMAuolWWVlL...olTWFL..AAu.h..K....W....u..pE...........AI...........p..t.......p......upY...F..........HhsAWu..lPul.hTlslLsh.sp......V...-....G.....D.l.o.Gl..CaVG...s..hp....s.LpsF....VLsPLhlhLhlGs..FLlsGh.l.u.L......h+lRp.hpptt...................ppscK.L.c...+hM...lR....IGlFohLYhlPsh..hlluCahYE.h.ht.W.....t...h.....h....t.......h.................t.................................................................................................Pph.lhhl+hhh..h.llG.IssuhWlh.o.t.KTh...pWtphhpt....p...........................................................	0	125	171	367
+386	PF01827	FTH	DUF38; 	FTH domain	Bateman A	anon	Pfam-B_67 (release 4.2)	Domain	This presumed domain is likely to be a protein-protein interaction module [1]. It is found in many proteins from C. elegans. The domain is found associated with the F-box Pfam:PF00646. This domain is named FTH after FOG-2 homology domain [1].	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.74	0.71	-4.59	87	1268	2009-09-12 02:26:25	2003-04-07 12:59:11	22	47	6	0	1226	1298	1	138.50	17	38.99	CHANGED	pphhp..thtphLcs....tpslpl+plp.lpthsh...........s.clhslLsh...FpsphLcpIpl.........................ptpphpphccls.pL-QWKpAKplp..hpsthh.......sI-plhHFppFpl.phsp..hoh.pDslclRD.......L.hpsss....Fppspl..............ph.phsshcls+lFp.Pp	...........................................................................................t....t.h.phlps...pp.l..p..lcplp....l..p.s...h..s.....................p...p.l..h...p.l.Lsh...hcs.p.hLc.plpl............................................tppt.p..h....h.p.h....p....c.l....h..ph....-...QWK....p.Ac.p.lp.........lp.shhh...t.............slc..p..h..h..Hhp....p.h.p..l...ph......p..........p........h..oh..pc........lh.......t....l+ch..................h..hpp.s.p.......h.p.h.h...................................................................................................	1	257	261	1226
+387	PF01913	FTR		Formylmethanofuran-tetrahydromethanopterin formyltransferase	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	This enzyme EC:2.3.1.101 is involved in archaebacteria in the formation of methane from carbon dioxide. N-terminal distal lobe of alpha+beta ferredoxin-like fold. SCOP reports fold duplication with C-terminal proximal lobe.	19.60	19.60	19.80	21.90	19.50	18.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.88	0.71	-4.47	36	245	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	155	24	95	260	64	134.40	49	47.64	CHANGED	MclNGVpI-DTFAEAFshpssRllITAtoccWAhpAApcsTGFuTSVIuCssEAGIEp.hlsPsETPDGRPGssIhlh....shstcpLccQlhcRlGQCVLTsPTTAlFsul...........tpphslGtpL+aFGDGaphpc..clsG.....R....+hW+lPl	.............l.-TFAEAFshtssRlllTAts.cWAhhAApshTGFATSVIuCssEAGIE+..LsPs.....ETPDGRPGlul.LlF.....uhutctLt..+Ql.pRlG.QCVLTsPTTAsFsGl..........................p...sscplslGtpLRaFGDGaQhuK..pl.sG.........+RaWRlPV..	2	27	67	82
+388	PF02741	FTR_C		FTR, proximal lobe	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	The FTR (Formylmethanofuran--tetrahydromethanopterin formyltransferase) enzyme EC:2.3.1.101 is involved in archaebacteria in the formation of methane from carbon dioxide. C-terminal proximal lobe of alpha+beta ferredoxin-like fold. SCOP reports fold duplication with N-terminal distal lobe.	25.00	25.00	37.30	36.40	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.72	0.71	-4.43	38	245	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	155	24	95	256	56	142.80	52	50.61	CHANGED	-GEFlsE-phGhh.cGVuGGNFhlhucsp.uALtAAEAAV-AlppVpGsIsPFPGGlVuSGSKVGop...Y.+h.lsASTN-taCPTL+sp.s.cSclPssVsuVhEIVIDGlsccuVtcAM+sGIcAAs.....pssGVl+ISAGNYGGKLG.a+F+L+-L	.-GEFlsE-shGhs.cuVGGGNhLlLAcspssALtAAEAAVsAhc.plssVIhPFPGGlVRSGSKVGS+...Y.+t.ltASTN-AaCPTL+uh.s.cScLs.....s....-lpuVhEIVIDGLsptsVttAM+sGIpAus.....thsGlhcIoAGNYGGpLG.h.h.L.t.............	0	27	67	82
+389	PF01728	FtsJ		FtsJ-like methyltransferase	Bashton M, Bateman A	anon	Pfam-B_1791 (release 4.1)	Family	This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.27	0.71	-4.29	239	10200	2012-10-10 17:06:42	2003-04-07 12:59:11	14	62	4426	60	2263	11482	3102	173.80	25	13.42	CHANGED	ahS..RuuaKLhph.cpa...........p........l..............................................p....ph.slDlGuuPGGaopshhpps.......................................................sspVhulDlt.h............................phshtl..........puDh...............tsh....hshp.plhph.....................................................................................................sDlllsDh.......................................p.phhuh....pLshsslt.hs................................p...................ssG...................hlsKlhp.....................stph.p.pllpplpp.......tFph.....................................................lthh+ss..........so+s.pu.sE.....a...llshth	................................................................................................................hSRuuhKLpth....hcph........h........l.........................................................................................ps.......tp.l..lDL..G...susGG.Wo...hhsptt.................................................................................................................stcVh.u..lDhG...s.s..........................................................t...............hs....p.h..................pt.sh...........................hch.........pshp...sl..h....h....s...t........................................................................................................................................................................................................................................tpsD.h.l.l.s..Dh...........................................................u.....................s......shl..p.h...............t.h.s...l...h.s....Lp...h..s......h..........................................................................................................L..p..............................ss..s.......................................h.s...lK....lhp............................................................hh......pllc.ph..cp...............h..p.p......................................................s..t..lh.+.ss..........hSRs..ps..pEh....ahls...h.................................................................................................................................................................................................	0	771	1367	1878
+390	PF02687	FtsX	DUF214; 	FtsX-like permease family	Bashton M, Bateman A	anon	COG0577	Family	This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.51	0.71	-4.35	133	37091	2012-10-03 05:18:07	2003-04-07 12:59:11	16	39	4654	0	8576	29605	7637	121.80	17	28.36	CHANGED	hhhshlhllluhlslh..shhthtlt.....p+ppchulh+slGhsppplhthhhhcshll....shluhllG.hlluhhhshhhtphh................................................hhhshhhshhshhhshh...hshhlshlsshhsshphtp.hss	.......................................t.hhshlhlllusls....lh......shhh.htlt.........pRp.cElul.h+s..l.G...ssp.pplht.hhhhE....shll......ullu..sllG...lh....l..u....h.h...h..s..h...h...l..t.t.hh.................................................................................................hths.h...t...h...s...h...h...s...h....l....h....s..hh.........hsh.l.l..s.l..l.s..u.h.h.s.shphhph.................................................................................................................................	0	3457	6175	7555
+391	PF04082	Fungal_trans		Fungal specific transcription factor domain 	Wood V, Finn RD	anon	Pfam-B_306 (release 7.3);	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.79	0.70	-5.52	102	10823	2012-10-01 23:57:08	2003-04-07 12:59:11	13	234	216	0	8645	11592	1	237.30	12	31.77	CHANGED	lphaaph....hp.sha............sll+c...ssahpph.............................spshLl...hsllslGsthtpptttpp.........................................................................phphhh.............pht.sspplhhlQ...uL....lllphathths...s..pphtht.....................apGhslp.hspshuLptpsst.p........................................hshp.tEh...p+.......RlaassahhDphhuhhhGpss......h...htspplphs....LPssss.h..stp.tt.t.............................................hhhhhpLp....plhsp...............................................lhs.lhshptphpppptp..........................hpplppplptWpp	................................................................................................................................................................................aht..........h....h..h.......................h....lp................ph.tth...............................................................................................h..lh................hsl..h..s...h..u...s........h.....h......t...t......t........t................................................................................................................................t.t.thhh...................................................t...h.t..t..s..p..l.t...t..lQ.............uh.................ll..h....s......h...h.h...h....tts....................p....p....t..s.ah................................hh..u.h..u..hc....h..u...h......p....l..G...L....+..p..p.s.s.t..t........................................................................................hs........t...-h........+..+...................R..l.....aW.s.lah...h...D..........p.............h...h...u.....h...t...h..G..p..s............................h...............hp.p..p..p..h..s.h........................h..P.....t.............t..............................................................................................................................................................................................................................................................................................................................................h...............................................................................................................................................................................................................................................	0	1444	4077	7109
+392	PF01363	FYVE		FYVE zinc finger	Bateman A, Armstrong J	anon	Pfam-B_655 (release 3.0)	Domain	The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions.  Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.  We have included members which do not conserve these histidine residues but are clearly related.	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.60	0.72	-4.08	174	4289	2012-10-03 17:27:21	2003-04-07 12:59:11	16	325	331	13	2818	4121	81	71.10	32	8.02	CHANGED	stWhsD.pps.spCht..Cpp.pF.s..............h..........h....pR+..HHCRpCGp....................lhC.......................................ssCS.........................spph.hh..............................................................t.ths.....psh..................................................RVCssCaptlpp	............................Wh.D.ppsspC..ht.......C.p..p.....p.F...s.............................h.........................................h.....pR.+......HH.C..R.........t.........CG.p........................lhC.......................................spCS................................spph.ls........................................................................................................h.t.t.pss...........................................................................................RVC.st.Capth..t..........................................................................................................	0	898	1408	2169
+393	PF01392	Fz		Fz domain	Bateman A	anon	Bateman A	Family	Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4].  The domain contains 10 conserved cysteines.	22.60	22.60	22.70	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.53	0.71	-3.73	26	1926	2009-01-15 18:05:59	2003-04-07 12:59:11	17	130	149	11	1122	1701	0	112.50	29	19.98	CHANGED	Cpsls..hshCpslsYstshhPNhLsHps..psEsthp.....hspahsLlph......pCpsshphFLCuhasPhC.hspht.....l.PCRshCEts+p.tCtslhpt...........ashtWP-hLcCschPh.pc.......hCh	....................................................Cpslp.....h.hC..p..s....l..s.....Y.s.h.T.h..h.P....N.....h.l..s..a.ps....pp-s.thp............................hp.t.a.h....sL.lph..........pC....p..s....p...l..ph..FLCuha.sPhC...p.p...h.......t.........................l.PC...R...slC...cps+p...tCp.slhpt.....................hs.htW.Pc..hhpCs.ph.P.tst.......C...........................................................	0	341	427	729
+394	PF01585	G-patch	G7; 	G-patch domain	Bateman A	anon	Pfam-B_585 (release 4.1)	Family	This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains.  This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.	20.30	20.30	20.30	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.14	0.72	-4.17	55	3420	2012-10-01 21:03:39	2003-04-07 12:59:11	18	129	386	0	2214	3446	25	44.30	34	7.29	CHANGED	ssshGhchhp+MGact...GpGLG.....csppGltpPlpsphpppp......tGlGtp	.............pshGt+hL.p.K.MGWpt.................G.p..GLG...............pp....t.p.......G.h...t..p..Plp..sphpp..pp.......tGlGh..............................	0	704	1102	1668
+395	PF01019	G_glu_transpept		Gamma-glutamyltranspeptidase	Bateman A	anon	Pfam-B_878 (release 3.0)	Family	\N	19.10	19.10	19.30	19.30	18.90	19.00	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.63	0.70	-6.02	52	5126	2012-10-03 21:14:07	2003-04-07 12:59:11	16	27	2591	76	1814	4680	4706	454.30	29	87.76	CHANGED	hclLcp..GGNAlDAAlAsshsLuVlpPpusGlGGGuFhllhsssstps..sl..suREpAPtssot.....cha...........tsttphsthGsh.uluVPGtlsGhtphac+aG..plshtpLlpPAIcLAccGaslstthutshtpttth...hpppssht.......phF.....hs..sGps.hcsG-hhp.pPsLAcTLctlAp..pG..............scuFYpG.c..lAcpllcp..........hpp...t..GGllTtcDLssYc...s.chtpP.lpssa..s.........thtlhtsPPsouGhslh.hLslL-pas....tt............spthHhllEAh+hAaucRsp.lG........DPsass....s....hppLlsppaspphtptIssppshs..........................................................h.......t..sssToHhullDppGNsVShTpolshhFGSslhsstoGllLNNchsDFo...........ls.sstsN............tltPGKRPhSohsPsllhc...sGpshh..slGssGGspIhsshhpsllph.....lphshs.............lppAlsuPRhap.....p..s........plphEt.........shstphhptLp..ptG+plphhts.sshstshhhh......................tsushhuuuDsRpsG	...................................................h.clLc.p..GGNAlDA.........A........lAsshs.LuVs.............p.P.p..us..G.l.G.G..suFhl.....l.......h......s.................s................p................s........t......p...........h.........................sl...................s.h.......p...thA....P...t....t..s.s..........pha.........................ttts.....t...t...h..s..h...h....u.h.......h..u.......l.u.l.PG..s.l....tuh....t........h.....h.....p.....+.....a...G.............ph.shppllpPAIp.lA..c.p...G.a....................ls........t....hs....p....h...h........t.........ptttt..........htp...........s..h.t.........................th.F........................h..........pG...ps...h......p...............G.......c..h.....hh..ps.....p.......LApTLchlAp..pG................................scu.F..Y..p..G..p.....lAc..plstt....................................hpp...........t.....GGh......lohpDL.ts..Y..p..................s..t...p.............p.P....lss.sa....t..............................................hhhl.h......P.P.s.u.s.G..........l.s.h.ht.h.L.s.lL-.ths.......htth.s.ts.......................................................spthHhhhEAh.+hA.au...........D.R.spa..l..u...............Ds.s..ahp....................hptLl.s.p..s.Y.h.tph..t.p......Is.p....p.shs...............................................................................t.....p.....tss...TsahsllDppG...s.sVS.......hTpolt.h..........hFGSul..h..s.........st.....s.....GhlLNNc.h.s.sFo..............................hs.ss..tsN......................tl.t..P....s.KRP.h.oohs.Psl...lhc.............s...............u.................p...s......hh...............sh.G.s.s...G.G..sth.....pshhpsllsh...............................ls.a..s.h.s....................hppAlst.PRhtt...............p........................plp.hEp........................sh.s.........p...h.h..p.tLp....thG.a.p....l....t...h....h...t........h........t....s...h...t...t..h.hhh............................ss..hh.uuuDsRpt....................................................................................................	0	561	1043	1459
+396	PF04114	Gaa1		Gaa1-like, GPI transamidase component 	Wood V, Finn RD	anon	Pfam-B_12685 (release 7.3);	Family	GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex.  Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase  that adds glycosylphosphatidylinositols (GPIs) to newly  synthesised proteins. 	19.50	19.50	23.20	20.20	18.90	19.20	hmmbuild  -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.80	0.70	-5.80	4	376	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	269	0	274	373	2	347.30	24	66.68	CHANGED	hpGpNlYGlLRAPRusuTEulVLsVPapsusu.phN.puuVuLhluLAcaFpthshWuKDIIhlloEpshhGhpuWLEAYHD.....shshh..pP..LphRuGSIQAAlsLElsosEssp..l-Vth-GLNGpLPNLDLhNlhppIht+cG.hsthph+hpspDhpopss..ps..L+pLhhhlhsQAsusspusHG..LF.pYRI-uLTL....R.h+uptphuaDhsshG..+AlEuhFRSLNNLLE+hHQSFFFYlllu.p+FlSIGsYMPullhLshshhLpAhptWhs.ttsshsL.cshu.....t..s.L.s...s.hhtl.asolsu.hLlophhthssalh.hLtpphht..hssh.hpssshhhLSl..huhhh................h.hhhlhsLlhhuhtlsslulhNFSLuhlsAhhhVP..lth.sKccspR.....olhhAsLshps.hlhhlslLhl..hphs.sPht.lhhcshphhhshls.uVhthlshsshla.VlshhahPhWllhhshohpK	..................................................................................................G.slaulhp.A.PRusu....sEuhVlss.s...........................s.........................p..............s..............s.....tulslhlslhpa..hp..p....hW.u.KDllhl..h...s...................p..........p.........h.................u....h....p....uWlcsYHs............................................................l...h..puGs.l.puAlsl-..h.s....t..t..........t............lplhh-GhNGpLPNLDLh...N.hh...............th....s.t..t..t......................t.h.....t...............t................................................................t..t...t.................hpt....hh..hh.hh..p...tu.....u.h.s.p.ss..Hu.......Fh.aplpulTl...............................t.s..h...t..p.....................s.....h..t..hG........+hlEuhhRslNNLLE+hHQSaFhYll.t.ppFlSIu.Y.h...shhh...lhhs.hhl............u..h....h..t..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	92	160	233
+397	PF01590	GAF		GAF domain	SMART, Hughes J	anon	[1]	Domain	This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.70	0.71	-4.09	450	14959	2012-10-02 14:34:25	2003-04-07 12:59:11	21	1267	4851	93	4355	20618	2072	147.20	15	24.89	CHANGED	shpplhpphhpplt.phhssspshl......................................................h..hptpthhh.hhhth.hsp............................................tthth.httsh............................hspshpsspslh...................h.........shhhtt...............ththpuh..hssP....h...hsp.......tp.........................lhGllsltppps....................ctasppc....hp....llpt.luppluhsl	.............................................................................................................................................................................................................................hhpth.hptht.ph.h.s.h.ct...shl........................................................................................h...h..p..t.....s.....t....h.....................h....h...t.h...s..h.sp....................................................................................................t...t.t....h....h......h...t..p.sl............................................................h.t..p....h.h....p....s......s...p..s.h.s...............................................l.t.....s....h...t.........p....p.....h.........t...........s..h..s......t...p..t..................................................th.t.h.p.u..h...lshP..................l..ht.p..................sp...................................................lh..G.ll..s..h..pppps.....................................+hh..s...t...t.p..ht...........lhps.hutthsh........................................................................................	0	1335	2627	3635
+398	PF01140	Gag_MA	gag_MA;	Matrix protein (MA), p15	Finn RD, Bateman A	anon	Pfam-B_229 (release 3.0)	Family	The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity [1].	20.80	20.80	21.00	22.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.88	0.71	-4.28	9	296	2012-10-01 20:35:47	2003-04-07 12:59:11	14	20	82	4	9	313	0	123.90	61	20.54	CHANGED	GQolT....TPLSLTL-HWcDV+cRA+NQSVEl+Kt+W.ThCsuEWPTFsVGWPt-GTFNhslIhQVKphVFp.sPaGHPDQVPYIVTWcuLAhsPPPWVcPFlsPs......hsPos.stPsuPs.PSsP.pss..LY	.............GQTVT....TPLSLTLpHWsDVp+hApN.QSVDVKK.RRWlTFCSAEWPTFsV....GWPpDGTFNlsII.QVKu+VFsPGPHGHPDQVPYIVTWE.ALAhDPPPWVKPFVsPK.........s..Po.AP.hPssPs..spsPspSs.................................................................	0	4	4	9
+399	PF01141	Gag_p12	gag_p12; 	Gag polyprotein, inner coat protein p12	Finn RD, Bateman A	anon	Pfam-B_821 (release 3.0)	Family	The retroviral p12 is a virion structural protein. p12 is proline rich.  The function carried out by p12 in assembly and replication is unknown.  p12 is associated with pathogenicity of the virus [1].	25.00	25.00	33.60	33.60	24.50	21.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.06	0.72	-3.85	10	138	2009-09-12 05:17:05	2003-04-07 12:59:11	13	8	48	0	0	153	0	81.50	71	10.13	CHANGED	PALTPolpsK..P.KPQVLP.DsGGPLIDLLTEDPPPYtsPtPsPPst-ssctEAssssEsP........sPSPMA.....SRLRGRREPPsADSTTSQAF	..........PALTPSIKsK..PsKPQVLP...DsGGPLIDLLTEDPPPYGsQ..PSSSst-sscEEAssTuEls........sPSPMV.....SRLRGRRDPPAADSTTSQAF.....................	0	0	0	0
+400	PF02140	Gal_Lectin		Galactose binding lectin domain	Mian N, Bateman A	anon	IPR000922	Family	\N	21.30	21.30	21.60	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.31	0.72	-3.67	126	1519	2009-01-15 18:05:59	2003-04-07 12:59:11	13	122	181	22	813	1468	19	79.30	33	12.15	CHANGED	LpCs.s..phlplp.hAsYGRss..s.sC......s...hppsp................Cpus....s.ohshlpp.....pCpG+psCs.lsss.sssF...uD.P.C.sushKYLpV.....papC	..........................................................LpCsss....pll.tIp.sAsYG.......Rss.....sth..C............st.....t..p..h.p..p.h..p...................................Chss.......suhphl...pp........p.C.p....s+..p.....p.....Cs.lsss..sssF....sD...P....C..s.G.o.h.K..YLpV..pYpC......................	0	314	482	674
+402	PF03127	GAT		GAT domain	Bateman A	anon	[1]	Domain	The GAT domain is responsible for binding of GGA proteins to several members of the ARF family including ARF1 [1] and ARF3. The GAT domain stabilises membrane bound ARF1 in its GTP bound state, by interfering with GAP proteins [2].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.10	0.72	-4.04	33	1104	2009-01-15 18:05:59	2003-04-07 12:59:11	9	17	265	13	629	997	2	98.80	23	18.93	CHANGED	tps-phuKht.scl-pVpsssclLsEMLsphssupppss-.-....Llp.......................-LhppCcphppplhcLh.........scspD--..sls-lLplNDsLspslp+Ycphscspps.tp....sts	...................................................t...t.htphh.splp.l.p.s.ss.clLsEMLpp.hs..s......s.....p..p..p...s..s.c..-......llp.................................-.LhppCcphpppl..hcLl........................................sp..sp-.--...h..l..tcl...LpsNDpLspsltpYcp.htpsp.......ssst.........................................	0	138	279	452
+403	PF00320	GATA		GATA zinc finger	Finn RD	anon	Prosite	Domain	This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors.  However there are several proteins which only contains a single copy of the domain.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.18	0.72	-4.60	69	3798	2012-10-03 10:42:43	2003-04-07 12:59:11	22	92	384	40	2299	3654	15	35.30	45	8.26	CHANGED	Cs..sCsTop..TPhWR+us..sGph...LCNACGLaa+hpthh	.......Cs..s..C..t..osp.....TP.hW..R+..ss............sGph.........LCNACGLa.aKhps..........	0	638	1149	1789
+404	PF00117	GATase		Glutamine amidotransferase class-I	Sonnhammer ELL	anon	Prosite	Domain	\N	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.44	0.71	-4.85	134	29637	2012-10-03 00:28:14	2003-04-07 12:59:11	23	151	6931	113	7451	26546	18089	186.40	22	46.33	CHANGED	lllDshtuhptslh+tltphs......hplplh..s......pth........................psculllSsGPGsst........httthphlpphhp.....plPllGICLGhQhlshshGu......................plh..........................ptt.hshpGtsp.ltp..t............hhhshspshhstphHuhtls.....t.lsps..hplsshstss.......tlhulhcppt.....hhulQFHPEshhsspstphLhshhlph	...............................................................................................llDhh...tht.tslh...ct..h.t....p.hs..................s.p.s...p...l...h....h..s...t.....t.tph......................................................................hpscu..l....l.ls...s....G......P.G.s.stt.......................hpt.t...h.p.h..l....p..t..h.hp..............p...l...P...l.....l..GICL.Gh.Q..h...h.sh.t.h.Gs.....................................................................................plh...............................................ptt....h.s.p..t.G.t....s..h.....l.t..p...t.......................................................hh..h..s...h..........p.....s....h...h...s....h.....p.......H...u....ht.lst.................................hs.ss......hp....l....s.....u....p.s......p.s........................thhu.....h.......h.......c......p..................s.....p..........hhulQFHPE..h....t..t..s..s..t..s..h..p.h.Lh.shh...h....................................................................................................................................	0	2366	4699	6278
+406	PF02934	GatB_N	PET112_N; 	GatB/GatE catalytic domain	Finn RD, Bateman A	anon	Prosite	Domain	This domain is found in the GatB and GatE proteins [1].	23.40	23.40	23.80	23.90	22.10	23.20	hmmbuild  -o /dev/null --hand HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.94	0.70	-5.55	147	4153	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	3865	37	1215	3100	3120	280.70	48	60.26	CHANGED	Es..lIGLElHsQLsT.coKlFsssssp.aus.....p..P.NopssslslGh..PGsL...........................Pl.lNccAlchAl+huLALssc.I...sph..spFcRKsYFYPDLPKGYQIoQaphP....lspsG..hlc..lp......................pup.......+c...............................................................lt..IpRlHlEEDAGK.lHpts.................................thohlDhNRuGlPLlEIVo-P....Dh+oscEAtt....alpcL+pllpalulsDssM-cGolRsDsNlS.................l+......................Gp.....t...........hGsRsElKNlNSh+tlpcAlcaEhpRQhclLc.............................................................................................................................................pG..t....p.l.QETRtaDsspspThsMRsKEsApDYRYFP-PDLsPlhlscchl-cl	...............................EsVIGLEVHspLsT.poKlFss.....sssp...FGs............c......PNopssslshuh..PGsL....................................PV...lNcpsVchAl+huLALssc..I..s.p.p..stFsRKNYFYP.....D.PKuYQISQ......a....-....t....P....IstsGhl-.lp...............sGpp.........Kc...................................................................ltIpRhH.lEEDAGKshHts..............................................................shShlDhNRsGsPLlEIVoc....P....Dh....R....S....scEAhA....YlcpL+pllpalGlSDsp...M.......-EGShRs..DsNlS..lR..P...........................hGp..........pp............aGTRsElKNlNSh+hlp...cAl.c...YEhpRQhcl.L..c.......................................................................................................................................................s.G...G......p.l....h.....Q.ETRha.Dps........p...s....pThsMRs.KEsA.pDYRYFPEPDLsPlhlsc-al-p.h..............................................................................................................................................	0	421	796	1040
+407	PF02637	GatB_Yqey	DUF186;	GatB domain	Bateman A	anon	Bateman A	Domain	This domain is found in GatB. It is about 140 amino acid residues long.  This domain is found at the C terminus of GatB Swiss:O30509 which transamidates Glu-tRNA to Gln-tRNA.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.59	0.71	-4.49	103	3872	2012-10-02 13:42:24	2003-04-07 12:59:11	13	14	3640	37	1195	3139	2254	147.40	34	29.94	CHANGED	-aFEpslpts..ss....s+tsuNWlhs-lhuhLscpshslpp...................lss...ppLupllph....IpcGpISsKhA.Kclh.pphh..ps.stss.........cpllccc.GLtplo..Dpstlppllc-llspN.spt.lcca+sGKp....+shualVGQVMKt.o+G+A.s..PphVsclLpccL	..................................................................................................caFEts.lttu....ss......sKhsuNW..l..hs-lhth...L.N.p......p.s....h.s.lpc........h..........................sl.oP...ppLupl.l.pl.........I.c.-G..sI.......SuKl......A.K.c.Vh.p.t.lh........ps...usss........................c.p.ll-c...c.G..L....h.Q.lo.............D......s.....u...s........l....psh.....lc-l..ls....s..N....spt...Vc....c...a...+........s......GKp........+u.....hGalVGQlMKs....o+.....G...p.A.NPphVscLLppcL............................	1	410	790	1026
+408	PF03615	GCM		GCM motif protein	Griffiths-Jones SR	anon	PROSITE	Family	\N	25.00	25.00	31.80	34.40	22.30	21.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.60	6	146	2012-10-02 23:28:20	2003-04-07 12:59:11	10	1	79	1	94	148	0	139.50	68	28.86	CHANGED	caDcFsEWsDGaVRaIYuscDccA+KHlSGWAMRNTNNHNspILKKSCLGVllCSpcCpLPsGuplpLRPAICDKAR+KQQsKpCPNptCc.G+LElhPCRGHsGYPVTHFWR+sGpuIFFQAKGsHDHPRPE.sKsooEARRuh	.....................aDtFpEWsDGaVRaI.You.c.-+pAQRHlSGWAMRNTNNHNsp...ILKKSCLGV.VVCu.ps.CsLPsGs+l..pLRPAICDKARpKQQcKtCPN..Cs.GsLELlPCRGHuGYPVTNFWRp-GpuIFFQAKGsHDHPRPE.oKspsEARRu.h..........	0	21	27	55
+409	PF03074	GCS		Glutamate-cysteine ligase	Griffiths-Jones SR	anon	Pfam-B_541 (release 6.4)	Family	This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS).\	      This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).	25.00	25.00	27.20	25.20	19.30	22.80	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.37	0.70	-5.40	10	455	2012-10-02 17:21:26	2003-04-07 12:59:11	11	6	292	4	308	460	7	297.10	42	57.32	CHANGED	IYMDsMGFGMGCCCLQVTFQAsNIsEARaLYDQLusICPlhLALSAATPFaRGhLuDhDsRWsVISASVDDRTtEERGlsPL................psp.hcI.KSRYDSlDsYlSsss...EcYNDIsLsIscclY-pLl-sG...IDchLApHlAHLFIRDPLslF-EpIclDDssco-HFENIQSTNWQTMRFKPP.....PPcS.-IGWRVEFRPMEVQLTDFENAAYsVFVVLLTRsIlSa..+lsFhhPlShVDENMKhApcRDAlLppKFhFRKDI..Cps.s....hssKsssso--suE....MSIDEIING..KcGsFPGLIP........llRpYLEstclDsDTRC.lpsYL+hISKRAoGEl.TsAcWhRpFlssHPDYKcDShlTDcIsYDLlp+scpIAs	...........................................................................laMDuMuFGMGssC.LQl.TaQuts.ls-uRhlYDpLsslsPlhhALoAAoPha+G.als-.DsRWshIusuVDsRT.cE..h...u......Ph..............................................tp.t.................hI.KSRY..sShs.Yl....u..t.............p....................................p.Y...sD.s.lshs..pplhp.p.LhptG........hDchLAp..HhAHLFIRDPlslFpEplp....s..pp.....s-.HFE....................NlQSTNWQphRFKPP...........P.s....s.s...s...lGWRVEFRshElQlTDFENAAassFlsLlo+.sI.....L.s.a..........plsh.hlPloplpENMphApt.psAshp..t.hFaFR.c.s.....................................................................p............p..........................holspIh.pG......p.............t........s.FsGLls..............l.l...pp.a..l......p..p.h......p....hs......p...pt.................l.tYLphIppRAs..Gpl......TsApahRpFlhpHPtY+pDShlspplsaDLl.th.tl..t....................................	0	114	166	260
+410	PF03009	GDPD		Glycerophosphoryl diester phosphodiesterase family	Griffiths-Jones SR	anon	Pfam-B_4008 (release 6.4)	Family	E. coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted [1]. This family appears to have weak but not significant matches to mammalian phospholipase C Pfam:PF00388, which suggests that this family may adopt a TIM barrel fold.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.62	0.70	-4.88	34	9993	2012-10-01 22:17:21	2003-04-07 12:59:11	12	139	4031	48	2657	7515	2527	235.00	21	65.67	CHANGED	HRGsusphP...........ENTltuappAhptGADhlEhDVplTKDGhsVlhHD..........tplscssssss.....................hlpchohp-lpphp................................................tst....h.tpth........................sTLp-hlph.........hssshphtlclp.hsphhthpt....hstthsthh.phh..........tstplhhpoFphcthphhpphts.....phshhhLhptss.ths...........tthphhts.shhsththhsts.......................hlpts+ppG.ltVhsaTlsst..................tphthhhchGVDGllTDpsst	..............................................................................................HRG..s....s...s.....h..hP.............................................ENT........l........t...A.hp.t.A.........h............p........h......G...s......c.....hl..E..h.Dlp..............hT+...Ds...p.............lVlhH.....D.............psl...c....R...so.ssps..................................................................................hlp-.hTh....p.-.l.pplc..................................................................................................................................................................h.t..............h.....s..p..t.h.................................hsoLc-hlch...................thp..h..t.h....t..l....c....l..c..............h....s....t.h.h.t................................t.h.h.......t.........h.h.....t.....hh................................................................................................................t....p...........h.h....lp..S..F..s...h.p...l.pth.pphts.......................ph..h...s..h...l.h...t........t.............................................h.t......h...t..t...........t..h..h..h.....t..h.t.......h.s...h..............................................................................................h...l.pt..h...+.p....t..s..h..l..h........s..a...Tlsp......................................t.ht.h.h....h.....p...h...s.......l......c....u.lh.TD.st.h..................................................................................................................................................................................................................................................................	0	842	1578	2169
+411	PF00626	Gelsolin		Gelsolin repeat	Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.46	0.72	-4.29	54	5387	2012-10-01 21:06:05	2003-04-07 12:59:11	17	133	440	183	3048	5007	35	78.00	19	21.63	CHANGED	ph..s.ss.hstsplpsscsallDssh...........plahWhGpp..ss.tcpshus.hstplp............pph.shs.hhp.spu...pcsspFh	................................h....s..s.hsts.pl.ps..s....D.sa..ll-.sst...............................................................plahWhGpp..........ustp....E......c......t......t.........u..h..h...hs..tplp..................................pphts..h.....s...hhh....pG...tEs.tF.............................................................	0	854	1348	2192
+412	PF01408	GFO_IDH_MocA		Oxidoreductase family, NAD-binding Rossmann fold	Bateman A, Griffiths-Jones SR	anon	Pfam-B_342 (release 3.0)	Family	This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.62	0.71	-3.59	52	20348	2012-10-10 17:06:42	2003-04-07 12:59:11	17	96	4230	256	6149	17689	10023	120.50	24	33.45	CHANGED	h+lullGs.Gth...upha...htshhps.pth.......clsulhs.sttpucth....upphshs.....sass..........hp.plhsps..c...lDslhlssPs......th....HhphshthLptGh..aVlhEKPlsh......ohp-spclhphsccps..........hh.ltlsa	....................................................................................................h+lullGs....G...th.............up.t.a.........h.t..s...h..h..p..t......ssh................................cl.s..u..l..s..s....h....s.........p....p....s..p.t.h................................up.p.h....s..ht..............hh..s.s...................................................................hc...cllsps.........p.............lD...sVh.l..s.oPs.............sh.......Hhp....hs..h...tA..lp........u..GK........HVh.....s.....E...K...Ph..uh..........shp-..sc.c....l...h....ph...Ac...c...p.s....hh.lhh...............................................................................	0	2220	4074	5250
+413	PF02894	GFO_IDH_MocA_C		Oxidoreductase family, C-terminal alpha/beta domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_342 (release 3.0)	Domain	This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.	20.80	12.60	20.80	12.60	20.70	12.50	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.30	0.71	-10.30	0.71	-4.29	37	12324	2012-10-02 13:21:44	2003-04-07 12:59:11	12	35	3630	193	3449	9524	4058	106.70	15	29.99	CHANGED	+chlppst.lGplhhhp..thhtspttt.spht.p............suGshh-huhH.lDhhphLhGt..spss...shh..hphsptsphtsst.......................hshthssht....ssthssshspshshphhhh	.................................................phlppGt.lG...c...l...h....h....h.....p.................h...........t...h....h...............t.......s...............s......t...h....t....hp......................tuuG...s...l...hD.hu.sHhlDh......s...h.a...l....h....G.........p.............s.....p...h...ss..............sh..............h.......h...........t..t....t............s.........................................................................h.h..........h..............................hh..........................................................................................................	0	1200	2256	2931
+414	PF00990	GGDEF	DUF9; 	GGDEF domain	Bateman A	anon	Pfam-B_112 (release 3.0)	Domain	This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain [1] and has diguanylate cyclase activity [4]. This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.97	0.71	-4.65	49	42746	2012-10-01 23:51:22	2003-04-07 12:59:11	16	1972	2995	26	12809	36762	3058	153.10	28	27.32	CHANGED	AthDsLTsLsNRphhpppLppthpps.tp....ppthullhlDlDpFKplNDpaGHpsGDplLpplAptLppslRp....sDlluRhGG-EFsllLspss.p....stphtpthcphlpphphsh.thsshth.lohSlGluth..........tpspshppllcpADpALYpAKppG+Np	.......................................................pDs.LTG.LhNR....p....h...h.p.....p...p.......l........p.......p.......h...h.........p.......p.....s......tt....................t..p.......t.....h.....u....l....l....h....l..Dl...D.p.F..K..p....l....N....D.....s..a.G....H..t..sG...D.....p.....lL.p.pl.A....p.t.l...p....p.......t......l......c...........p................s-..............h............l.............u...............R..............h......G.........G....-........E..F...s.....l...l..........l.........s.....s...s......s...t.p........................p.........h.....t....p.....h.........h.p....p...h...l...............p...................t.............h.........p...................h..............................h.................................................t............t...........h..............t...................h........t.................l.....o...s......S..l..Gl....u..h.h...................................p...s.....p......s.....h.....p....p....l.....l....pp...A.D...t.Ah.Y.p.A.KppG+s......................................................................................................	0	3883	8047	10652
+415	PF03321	GH3		GH3 auxin-responsive promoter	Mifsud W	anon	Pfam-B_3652 (release 6.5)	Family	\N	19.60	19.60	19.60	19.60	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	529	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.79	0.70	-5.99	64	945	2012-10-02 15:58:18	2003-04-07 12:59:11	8	9	449	8	439	940	720	439.50	24	91.84	CHANGED	ctlc......p..h-pht....................psst...plQcclLpclL.ppsssT-ah++ashp......uh..hs........c..........FpppVP.......lhsY--l.cPaIcRltsG-........ps.llhsps.lphFstSSGTouupsKhIPhoc-.lcphphhtuhthhh..hppphssh.hpGK..hLths...sphppp..GhhhGsloshhhc..s.h..hp............hhpsPsptlht.-sapshhppllpthh.cpclttluul.uhhllhhhchLEpphpch...........................................................ltclWPshc.lhshsssuht.Yhtphcthhsu.h.hh.psYsuSE.Gahulpsp....spcsuhhlh.shu.aaEFlPhcc.t............................sphlsLs-VclGppYtlllTThuG...................LaRYplGDsl+h.Tuhpst..plphssRpphhlslhu-+hstcclppAlppu....h.ptt.....shpls-aT.st.sp.h.stsu+ashhW.lpsc......st.........................shp..phsptlDpuL...NssYctpRptshplsslcl+llptGsFpchhc.thu+.Gu...QaKsPRhs..sspph..t...l	.........................................................t.....hp.hh..ppst...thQpplLtpll.ppstpopahp.pa.tht...............t.h.shp.................p..........FppplPlhsY-ch.pshl.pR...h.hp.Gc................ps..ll.h.st.....lhhahh.o.S...G..........To.ss...t...KhlPhspc....hpphp..hshth...hh...........htp...s......p.G+..hh.h.....th.p...ss....h...ht.shts.....h..h..p...s.h......hp..............p.Pst........h...h.....sthp.p.h..httlhpthh.ppplthlu...uh.s.hhhhhhchlp.t.....phpp.h..........................................................................................................htcl..WPphp.l.hhssssht..Yhtph.c.t.hhs....t..h.hh.phYsuSE.u.ah.uhp.p.............................pp..s..s..h..hlh.shu..aaEFlPhcp.t......................psphlsLt-VchGppYtlllTT...uG...........................LaRYplGDslch.suh....t.s.....t............phphssRpph..hlsh.u.-c.h.tpphppAlppu.........h..t..........shplh..-ao....sh.....s........t...............................st...........s..c..........hhh.W.lpht......sp.........................shp...phsthl-ptL...sssYcttRht.hsltslclphl..p.ts..h..Fpphhc..hsp.Gu...QhKhPRh....p.......t.........................................	0	135	318	377
+416	PF00288	GHMP_kinases_N	GHMP_kinases; 	GHMP kinases N terminal domain	Finn RD, Mistry J	anon	Prosite	Family	This family includes homoserine kinases, galactokinases and mevalonate kinases.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-9.32	0.72	-3.91	455	15529	2012-10-03 01:04:38	2003-04-07 12:59:11	21	62	4900	114	3877	10927	3091	64.70	24	18.95	CHANGED	clpl.pssl....Phu.uGLGSSuusssuslhu....lsphh.....s....h.s.............l........sp............pl...hphuhtsc..........tGsss....ssshhGs	....................................lplpssl.....P.h.u.uGLuSSuushsusl..hu.....hsphh........s...........h..s............................................L........sp.................................pcL.........hphu.t...ts..E............ts..ss..ssshhG..............................................................................	0	1260	2384	3266
+417	PF00594	Gla	gla; 	Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	Bateman A	anon	Prosite.	Domain	This  domain is  responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).	20.40	20.40	21.20	20.40	19.90	18.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.92	0.72	-4.27	29	998	2009-01-15 18:05:59	2003-04-07 12:59:11	15	54	109	47	394	801	0	41.10	45	11.04	CHANGED	lEEhctGslEREChEEhCshEEApEhapss.tTptaap+Yhs	..........hEEhppGsLEREChEEh.CsaEEARElFE.s.sp.cT...pt.FWppYh................	0	28	60	159
+418	PF00208	ELFV_dehydrog	E_L_F_V_dh; GLFV_dehydrog; 	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	Finn RD	anon	Prosite	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.48	0.70	-4.80	124	6466	2012-10-10 17:06:42	2003-04-07 12:59:11	16	23	3999	221	1773	5816	1828	223.60	33	52.44	CHANGED	GGS.hsRscATGhGlhahscchhcp..ttp...plcGppVslpG..GNVutasschhhch.GA+lVulSDupGslh....c.sGl......clptlhch.+pppts..lssas.............c.hh.ss..p....................ht.......l.......csDlhlPs.AhpNplstcsAc.hl.....+.......s+hlsEGANhPsT..-Ahc.lhpcpG..........lhhsPshhANAGGVssSuhEhsQN.tth.WopEcVsp+Lcpl...........Mpshacsshptupc..hshs........hhtuAslhuhp+VAcAhtspG	.........................................................GGS..hsRscATG......hGlhhhsc......phh..cp....shs...................h.cG..t....p.V...s...l...p.G...GNVutas.s..c..h..h.h..........p.........h...G..A..........+..V....l..s..h......S.....D......u.....s.......G...h...l.h......s....s...Gl........cl.stLh..c....h....+pppts........lspas......................thp.hh...p.st....ph..............................................................ap........h.......psD.lhlPs......A.h.pN.plst...c.s.A.p.hl................................p.....................s...phVsEGAN..hPo.T.....-.A.....h.........c...lh.p..c..p.G...............ll.hsPshsuNA.G...........G.......Vs.s.S.h..h.EhsQN..........t.h.W..s..t..-cl..pt+Lcpl..........................................Mtshapt...s.h.ph.u.pp...ths.................hhhuA.hhuh.+lspAhh.pG......................................................................................................................	1	635	1175	1539
+419	PF00042	Globin	globin; 	Globin	Bateman A, Chothia C	anon	Structure_superposition	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.33	0.72	-3.71	73	6000	2012-10-01 21:46:00	2003-04-07 12:59:11	17	34	2886	1971	1261	5331	34	99.80	25	43.59	CHANGED	ppthlpssWsp.lhs......ph.thGschhtclFpsaPps+shFsph.ts.p.....tsssphcsHut+Vlsulspslspl.....s.slpstlppLuspHtpct....lssspFphhtpslh	........................................hshlpsshsh.ltt................pssch.ssch........h..t....R....hF..t..saPp.s.p.p.hF..s....ph..........s.t...................ss..t.phpspu..ppl.hs.ulsphlppl..................sl...t...sslppL...u.phH...sshh........V.cPppapllupsL.................................	0	348	594	949
+420	PF04898	Glu_syn_central		Glutamate synthase central domain	Bateman A	anon	Pfam-B_455 (release 7.6)	Domain	The central domain of glutamate synthase connects the amino terminal amidotransferase domain with the FMN-binding domain and has an alpha / beta overall topology [1].  This domain appears to be a rudimentary form of the FMN-binding TIM barrel according to SCOP.	21.50	21.50	21.60	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.48	0.70	-5.15	37	3372	2012-10-03 05:58:16	2003-04-07 12:59:11	9	34	3044	15	950	2992	3369	283.90	42	18.60	CHANGED	lhppQpAFGYThE-lchlltPMAcsGpEslGSMGsDoPlAVLSc+s+hLYcYF+QhFAQVTNPPIDPlREp..........lVMSLpohlGscuNlLc.sspp..s+plpLcoPlLsps-............................hpp.l+sh..........pthpstslshsashp....pu............................hpu.LcsulcplsppAcpAlcsGtslllLSDRp........hstp.+ssIPu...LLAluAVH+HLlcpslRscsullVEou-sR-sHHFAsLlGYGAsAlsPYLAhEolpp..htccshh........phshppshpNYp+AlspGllKlhSKMGISTlsSY+GAQIFEAlGLup	.................................................h.phQptFGYotE-lchlltsMupsG...pEslGSMGsDoPlA..VL.S.pc.s..+hLacYF+Q...hF...AQVTNPPIDs.lREp...........hVhSLtohlG.t.-.h.......N.l.L.s...........st..tp.........s+...+l.plpsPlLsp.s.-...........................................................................................................hpp....lpshpp................ppac..sppl..sh.sasss....................................................................................tps...Lctulccl..ssc.A.ppA.V.c.....s.G.s.s.lll.L.SDRs...................l.s.p.s..+hsIPu...LLA.luAVHp+Ll.......c.......p.......s......LRs.psullVEoGpsR-sHHaAsLlG.aGAsA.l.s....PYLAaE.oltc.........hhcpttl...........................sh.s.h.cpshpNYtculsKGlhKlMSKMGISTltSYpGAQlFEAlGLs.p...........................................................................	1	289	615	816
+422	PF04960	Glutaminase		Glutaminase	Bateman A	anon	COG2066	Family	This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.	19.80	19.80	19.80	19.80	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.78	0.70	-5.43	17	2528	2012-10-02 21:13:33	2003-04-07 12:59:11	10	25	1760	57	544	1601	173	277.00	43	80.87	CHANGED	GpVAsYIPtLA+ssssphGlulsssDGphhpsGDschsFolQSISKVhshslAhtchGtc.lap+VGpEPSGpsFNSlstLEhcp.uhP+NPhINAGAlsVosllpucss.t-thphllphlcplsGspplshsptVhpSEhpTu.RNtAlAaah+phGshpp-l-...ssLchYF+tCulchoCpsLAhhushLAssGhsPhosEpVlstchs+phtAlMhTCGhY-sSGpFAa+VGLPuKSGVuGGIluVVPs..........hhululaSPsLDchGNSltGsthLcpLuphhshSlF	.......................................GclADYIPtLApV.s.ssphGlAlsT.s.D.G.p.h.a.p.A....G....Du.....chp.Fol..QSISKVhoLslAhpc..h..Gtct..lap+VGt-PoGp.sFNSlltLE..h..cp.GhPpNPhINAGAlslss.h..l.......p.......u...........c..h.......s........p........th.....pclLchhcpLuG........p..p....l..shsptV....spS.Eh.p.p.u.t.RNtAlAah.h+..oh..G.h..p..s..Dsp..........psLcsYh.+tCulphssh-LAphushLAstGh.s.Ph..s....s......c.pV.lss..pp.s+plpAlMhTs..G..hYstuG..-F.Aa...............+....V...G.LPuK.SGVGGGIlAlVPs...........phuIulaSPtLDpt.GNS.ltGhthlc.p....Lspph.Ghsla..............................................	1	146	287	427
+425	PF04488	Gly_transf_sug		Glycosyltransferase sugar-binding region containing DXD motif   	Kerrison ND	anon	DOMO:DM04307;	Family	The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other  sugars, phosphates and proteins.  DXD-containing glycosyltransferases all  use nucleoside diphosphate sugars as donors and require divalent cations,  usually manganese.  The DXD motif is expected to play a carbohydrate  binding role in sugar-nucleoside diphosphate and manganese dependent  glycosyltransferases [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.52	0.72	-3.63	22	1796	2012-10-03 05:28:31	2003-04-07 12:59:11	10	51	807	0	967	2109	434	94.40	21	24.68	CHANGED	spchhtshcohh.phpP-...hphhlhscpht..............................shphlhpp.ss.......hh.phhs......hh.h.hthuDhhRhhlLa+YGGlYhDhDshslpsl.......sslhsppthh	.................................................................................................................................................................................hpphh..phpPs.....aph.h.h.hscp........................................................................................................................................h.thh..hpp..hs.............hhpsap............p.h..h....h.h....tuDhhRhhlLa....phG.GlYhDhD.sh.sl+sl.......s.hh......t.................................	0	321	557	794
+426	PF00722	Glyco_hydro_16	glycosyl_hydro9; 	Glycosyl hydrolases family 16	Bateman A	anon	Pfam-B_759 (release 2.1)	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.48	0.71	-5.00	120	4255	2012-10-02 19:29:29	2003-04-07 12:59:11	16	172	1239	83	2173	4494	761	179.30	18	46.71	CHANGED	hsppass.sasssps.h........s.......tslsLslc+......................to.GushpS...pptahaG...phpsplK..supusGlVouFal..s...o.ts...sspDEIDh.EFLGs.sssp......lpTNha....spGpus......p....E.phhh...haDso.psFHsYulhWssspIhahVDGhslRphpppps...s....s.a...Pp.pPMp.lhso..lWsus.......sausptG..........hhphDWst	..............................................................................................................................t......h......ts..........h.l..thtp............................................hs...uutlpo...............ph.p....h....h.....a...G..............p.h...c.s..p..hK...........hst.....u.s...G.h.....hs.A.hah......p...................s............s..s..ps....E...IDl..E..h.......l.......Gs..p.ssp............................hp.s..s.....l..a..................sp.u.tss......................................p.........ptp.h.h..............h.....s....ss....s.saH.....s.....Y.....s.....l.........................W.......s.........s.......p........p........l..h...a....h.l.....D....s.........t.........h.t.....p....hpttt................................a...........P............ht....l....h...h....s........a.s.ut..................t..........................hta...............................................................................................	0	645	1357	1879
+427	PF00704	Glyco_hydro_18	glycosyl_hydro8; 	Glycosyl hydrolases family 18	Bateman A	anon	Pfam-B_574 (release 2.1)	Domain	\N	29.60	29.60	29.60	29.60	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.36	0.70	-5.00	165	8946	2012-10-03 05:44:19	2003-04-07 12:59:11	23	253	2235	288	3234	8695	370	279.40	18	59.57	CHANGED	tpllsYas....pau.htts..................h.hppls.......pthoHlhauFsslssssth..............................................................tt.ststpsthpphspl+..ppss..slKlllSl...GGht.us.............sasthstss......pt+pt.FlpSshphlppat.....................hDGl.DlDWEassst...............................ctpsastllpcL+pthpp..........................phhLosA..........hssss....hhpth...shsphtph.lDalslhsaDahu......htt......suhpssLasss..............................................................hssp.slphahpts.ss.spKl.hGhshY.upuaphsss..t...............................................s.ttuhhsapplsphh.........................tht.thsss.spss.ahhps...............h..lsa-sspohttKspahpptslGGlhhWsl.s.hD	........................................................................................................................................................................................................................................h.sh.h......h.sh.h......................................................................................................................h..t.....h....t...ht.....t.......th..p...h.h....h...u.....l............G..Gh....tt.........................h...t.h..s.t.s.t...............tt.tpt..a.hp..shh.p.h.h..p..p..hs......................................................h.D..G..l...D............l...D....aE..hssst....................................................................stps.as.hL.lp.....pl+.pthsp.................................phhL.o.h..A...........................h..ss.s.t...............hhpth......ph......t.....t....h........s....p.......h.....l...............D......a.ls.l...M..sY....D...hhu.......htt................ss..ts..s..lht.........................................................................t...h.p.......s.l...p...h...h........h...t........t...s..hs...sp..K..lhlGh...s.ha..s..h..sat................................................................................................................................h............................................................................................h.....h...................................h.....h...s......h..p...........................t.h...G...h..............................................................................................................................................................................................................................	0	1050	1817	2735
+428	PF02055	Glyco_hydro_30		O-Glycosyl hydrolase family 30	Mian N, Bateman A	anon	IPR001139	Family	\N	20.20	20.20	20.50	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.55	0.70	-6.30	3	1151	2012-10-03 05:44:19	2003-04-07 12:59:11	11	52	589	84	517	1057	187	328.70	21	77.79	CHANGED	AsDCspKTF.KTGlVCVCNlTYCDEI.PPlslshGQAApYTTS+SGARLHRDVlYATso-PhToLHhTIDSSKKYQTIQGFGSTFSDASGANLKSLPDphuDLILKQYFSDoGLNLQFGRVPIASsDFSuRVYTYsDss-DYsMpNFSLs+EDaQWKIPYI+pAQKYNpc.LKLFAuPWoAPGWLKTTsussGhGuLpGpsGDsYHQoYA+YFV+FLEEYuKsGIpFWGLSTQNEPTuGSDKKsKhQShGFTAEaQRDFIKpDLGPALAuSouGKNVKLLILDDNRGNLPKWADTVLNDhDAAKYVuGIAVHuYQD..uEoDsHLsETH+pHPNsFIFGTEASEGSKSKDppVDYGSWDRAtDYuSDILDNhNNWVTGWTERNLlLDApGGPSWVSsFsDAPVIAFPAhAQFYKQPMFYAIAHFSHFIKPGAVRIDHSLNhhN.ElEsoAFLNPDGSKVVVlLNKuSLsss.aoLoIKDsAcSpsHYphTLSP+sIlTLYIQ	..........................................................................................................................t..........................................................................................................................................................................................................l....l..........t...p..h.Qp.h...GhG..ss...hsttsh........h.......t...h.......t.....p..t...........hh.......p.........ha....s..........................p.................t.......h.thshhR......h........sh.......su....s.....D.h..s................t..............a..s.h..........s....c.................t..........D......t............h.....t....p.....h...s......h...................................p......t..........................l...s.hl.p....t..h.......................t......h..........s............t....h.p..lh.u.oPWosP....saMK......s.......s...t............t.........h...........................................................s...................h...........................................................................................h......t..........s..........aApYh.hcal.pt.h.t.t.p.Gl..h.slohpNEP....................................h...s...hhhsst.....t..tta...hht....LtP.t......ht...tt................t.htl..........h............h..........h.....-.........p..........p..................................................t...............h..................................h......h..t.p......t...........s.....p...h..h.tGhuhHhY....................................h............h....t..h.P..p.h.......hh.oEt.......................................................................................................................................................h.......h..h...t.....h.....h..........t...hh..Wshhh....p....................s..........t...........................t.....................t........h.......h..............t............t.........h.....h.....p...........a.Y.hhuphu.+al.....G...u.p..lt.............................................................h................suh......p..s......-.s.p.h.s.h.l.h.h.N.t.t..........................................hh......................................................................................................................	0	224	348	456
+429	PF01055	Glyco_hydro_31	Glycosyl_hydr15; 	Glycosyl hydrolases family 31 	Finn RD, Bateman A	anon	Pfam-B_369 (release 3.0)	Family	Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null --hand HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.43	0.70	-5.66	107	5543	2012-10-03 05:44:19	2003-04-07 12:59:11	21	109	2144	97	2001	5559	314	398.50	24	54.47	CHANGED	YhhsGs...................s..s.pcllcpY.sploG..........+ssh.PhWuh.Gaap..sRasY..........ps....ps................................................cltplsppaccpsIPl-shahDh-..............Yhc.shc..sF...oactppF..........P......................pscphlccL+.ppGh+hlshlcP.........slptsps.......h.sapcuhppsh.al.......+.pssG.p..................hhuts.Ws.....................s.........ssasDF.....hsP.c.sppWW.tsphpp....hhsp.........ul-uh.WhDhsEsus..........h...........................................................................................................................................................................................................sh.shsshphsss............pphchHNlYuhhhspusacu..lhp..h.psscRsalloRSsasGup+auut.WoG......Dst.usW............pslph...olsthLshu.lsGlshhGsDluGFtus...........sst.....ELhsRW.hQhGuFhPahRsH.sshs....sptp..................EPahasp....spshh....+phlplRYpLLPYlYohhhcupps.GhPlh.RPLhhcaPp.D....tpshs.lccQahhGs.s...lLVuPVl.................pps.ssphpsY.LP......pG..p...Wa-hh......stcth....puG..p...hlp..l.suPl..splPlalR..sGsIl	...................................................................................................................................................................................................................................................hh.G...p.....ttlhppa.tt.lsG.............ps..s.h...P.h.a.......u........h...Gh.h........sp.hth.................s.....pp...........................................................................p.l...p.hh.ct..h....p..p..t...s..l.P......h............s...s.h....h.hDh.......................................................ahp...shp..........sa................p.a..s.....t..pa..............................P..............s...p.thl.p.p.l..+..p..p.G..h..+.h.h.h.h..l...p.P........................hlttpps......................a.pc..h.h...p...p...s.h.hl.................p..p.pu...t...........................................................................................h....h...th...a.........................................................................................s........ssh...D..h.....hs..P....p...stp.a.a..t..p..h..h..p..t.......hhtt...................Ghs.s.h.h..h.................Dh.s.E...........................................................................................................................................................................................................................s.ssh.h.h.ss...............p..p...h..+N.h..........a.s..h....h................h..s..ps..shps................htp........................tp.....csh....l.hs......R.........u........u.h...s.Gsp+.a.......s.sh....W..sG...............Dsh....ss....W.....................ps..ht.pl.ts.Lshu.hsG.h.s...............h.h...........u...tD.l..G..GF..ss.....................sst................................ELh.h.RW.h.phG....s.a....P...h.h.Rh..H....s..s.s........t.........................................-PW..a.spt.............stsh..h..................+ph....h....p....l.R.h.p.L..h.PYlYshhh.p.....s......p.......p..p........GhP......l.h..RP..h...hh.c...asp....D.....................t..s.h..p.....l.........p.....p.............p.a........hh.Gs..s..................l.LVu.PVh.....................................pts...t......t.....p......h...ph.....Y..LP........pu...p...............W....hchh.......................ss.p.th...................pGu...p..............hhp...........h.tssh........t............p........l.P.l.ah+sssh..................................................................................................................................................................................................................	1	765	1179	1663
+430	PF01532	Glyco_hydro_47		Glycosyl hydrolase family 47	Bateman A	anon	Pfam-B_958 (release 4.0)	Domain	Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).	20.40	20.40	20.40	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.47	0.70	-5.83	139	1956	2012-10-03 02:33:51	2003-04-07 12:59:11	15	40	313	21	1367	1890	72	398.90	31	70.19	CHANGED	hFh+uWsuYtc................aAaspDELpPlSpss.............pss..........................h....s...shGhTlVDuLDTLhlM...........shp..................cEapcuhcalt......ppl..s...............as.................st.t...l...........slFE...........................TsIR............hLGGLLSAatL..o...............................................tcsh..................lLc+Ah-L.u-pLh..sAF.pT..s.oGl.......PhsplN........................l.........tp...st.t..thsst.........................................................ts..s.....h.AchGoltLEFsh............LSpLTG-spYhchsp+shphlhp.........ttp...GLhPhhl...sspsGpas.t..............................................................................................................................................................phslGutuDS......aY........EYLlK.........talhh..u...t...p..................................p............................ahchap...........................puhpulpca.hhp.......t.............thhalup.....h..............t...th.hps...ph-HLsCFhuGhhuLuuh.h..........................sclchA.pclscsChphYpph..oGlhPEhhphs....................................................................s.......thhhp........................................................................................................................................................................tstpYhLRP..............EslESlaahYRhTsD.pYpchGWchapulpc.ts..+s....ps.............................GauulpDVp........................sp............hpD..........................pMESFa..LAETLKYhYLL.Fs...........-ssh..ls......................LccaVFNTEAHPl.h	..............................................................................h.puapsYhp..................a.Aa.shDEL.pPlo.p.ps................................ps..........................h......ssh.uhTl...lDuL..D.TLhlh............s..p...................p-Fpcuhph..lt..........pl...s....................................as............s...t...l........slFE...........................ss.I.R..........................hlGG..LLoA.a.ls...............................................................................................................tpt.hLphAh-l.u.p.t.Lh..sAF..p...T.s.ou...l...........P...h.s.hls...........h.......tp.t.h.........sst.....................................................................................ts......h.Aphuol.lEFt.h..........................LSpl.TGssha..p..hs..p..p.....hhp.hl.p................G.Lh.s..hl......ssp..sG.pah...t...........................................................................................................................................................................................................................................................................................................................................................................................................................................tphslGu...hsDS....................aY.....................EYLlK............talhhs............c............................................................tt...........................hhpha...........................................pu.h.p....ul.pahhht......s...............hhhlst.hp...............................th.hp.h.hp.p.Lss..F.hsGhhsLu.....................................................tp...h.p..hAhpltps..hhth.a............pph...shhPEhhpht.................................................................hp.........................................................................................................................................................................................................................................tptha.L....R....P........E..h.lEShahh.a..R.h....T..t....D..........h..Yhc.............hGh..p......hh..pu.lpp..hs..+s..ts.....................................GauulpsVh..........................s..sp......................hpD..................................................p..h-......SFaL.......uETlKYhYLLFs....pss........ls.............................................................hspaVFsT.....EAHsh...........................................................................................................	0	462	748	1108
+431	PF03200	Glyco_hydro_63		Mannosyl oligosaccharide glucosidase	Mifsud W	anon	Pfam-B_2589 (release 6.5)	Family	This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyse the specific  cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway.	19.00	19.00	19.00	19.00	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	801	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.88	0.70	-13.48	0.70	-6.70	15	722	2012-10-03 02:33:51	2003-04-07 12:59:11	11	9	421	0	454	910	161	431.20	23	58.05	CHANGED	lsllhlu..htshhhhthhhst..............+slssasss.h.p.s..hpsttssshaWGoYRPplYFGlRsRoPcSLlsGLMWhs...s.tsGtsslRHh..CEQGD.sLssYGWhcHDGRsFGpQcIpD.ps.hsLpT-FVKp.t.t..aGGDWusRIpupspsusps.s......psSLhaYsusEGps.....slsscl.stpspls........................hloGpop-LGpFplpl............ps.sss......hhcspahuhpsPs...lhplpD.......................lVhpsLppphpp....hss.t..tphlslss.h.........pspppuNllhh......QlohpsshphDIlFpSusstcpsp.............LTGpslsspLcc+pppF-cKFpppFsLppKh...............hsssphpFA+sALSNhLGGIGYFYGsSlVp.......................puhpptcslhYhPus..........LaTAVPSRPFFPRGFLWDEGFHpLLlt+WDscloh-lluHWhsLlNs-GWIPREQILGsEARSKVP-EFllQpspsANPPTLhLslccLl-shcsst..t..................................thhsaL++laPRLcsWFpWFpsTQ.pG.l.s..........oYRWRGRshs....LNPKTLsSGLDDYPRASHPossEhHVDLpCWhuluopsMsslAchLGpscshtc.......ptts.lssN..LschHWu-cppsYsDaGsHTc...................................tVtL....s....t.............h.R.s..hptPphphV.sphGYVSLFPFLL+lls.sDSs+LcplLclI+DscpLWosYGLRSLS+oushYhp+NoEHDsPYWRGPIWINhNYLhLpuL+HYu.....phsGPapspApplYpELRsNLlsNlh+QYppTGalWEQYDDp.oGcGcGs+sFTGWoSLVlLIMuEpY	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.hh..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..........t......h............h.h....h..............t.h.h...............s.........p................+L..........t.plL..p.hhhD.p.c.h...hos.....aGlR..SLS...+..............p...............s.....................h...............a....h.............p........t.............p..........s.......................................................................Y...................WRGP.lWhshNaLhlcuL.t.c.at.......................h.s.....................................................................................................................................................................................................................................................................................................................................................................	0	176	289	401
+432	PF03648	Glyco_hydro_67N	Glyco_hydro_67; 	Glycosyl hydrolase family 67 N-terminus	Finn RD, Moxon SJ	anon	CAZY	Domain	Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the N-terminal region of alpha-glucuronidase. The N-terminal domain forms a two-layer sandwich, each layer being formed by a beta sheet of five strands. A further two helices  form part of the interface with the central, catalytic, module (Pfam:PF07488) [1]. 	22.00	22.00	22.10	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.72	0.71	-4.08	38	324	2012-10-01 20:56:08	2003-04-07 12:59:11	9	8	239	17	133	354	23	111.20	22	14.45	CHANGED	sWLRYt..lsssth..phpshsspIVslsso..sslpsAtpELppGlpullGpsh..p.hssphsppss.......lllGThcshph.....ttshsp....Lss-Gahlpo....tpspllIsG.ps-pGsLYGsFca	...............................................................t.lh.h..tps.......................sslphAhpELppslptlhGpps...t...lh.s.p.ssppss............lllGohss..h......tth..t..h....s..t....t...ht....p...l....t..p....EGallps....................t.............s...pptllIsG.sscpGsLYGsach..............	0	49	88	115
+433	PF03663	Glyco_hydro_76		Glycosyl hydrolase family 76 	Finn RD	anon	CAZY 	Family	Family of alpha-1,6-mannanases.	20.60	20.00	20.60	20.00	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.64	0.70	-5.08	90	1340	2012-10-03 02:33:51	2003-04-07 12:59:11	9	29	493	1	758	1302	51	320.60	20	73.21	CHANGED	Sl....csAAsplAtshh.saYpGsp...G...shsGhhsss.......haW......WpuGuhassll-YWhh....TG..s..........soYNcllppulhaQsGps.........c.ahPsNtops...GND..DQuFWGlAsMsA.AEtsFsss..sst.p...WLsLAQuVFNs.s.sRWDsp....s.CsGGLRWQIasas.sGYsYKNolSNGshFpLAARLARYT..sNp..T.Ys-WA-KlWD.Whts.ssLl.......s....sp..apVaDG.s.....ssssN...C.os..hsph...pWoYNtGlaLsGAAaMYNh........T........pu...s.......tWpsRscslLsu..sh.....sh..F..Fsss...........lhhEh.uC......Es........t.p....CssDQtsFKuhhuRaLuhTstls.P..Th...-...pIhshLpsSApAAA.ppCoG...................us..ssp...hCGhpWh...ts.a.....DGhh.G...lGpQhuALpslpuhll......t.ssshoss	.......................................................................................................................................................................................s...........................h...................W.tuth.hs....s......hlchh.hh......tt...s............................sphp.p...h..htp...thh.hth..stt............................h.s.h......s......s......t..............h......D....Dtsa.......hu.l.u......hhp....u......hc..........hshsp............p..........a.L.p.hAp.tl..asphh...s....tWssp..................s.......G..Glh.W.............p.................................p.......s.......h.....saKNs......h.........uNush...h.h.u.u....+....L..h.p........h.................s......tsp...................p..YhchApch.ac.Wh..tp......sll.......ts......pp......hh.l..hDGh........................phps.......s.tp.....hsp.h.........paoYNpGsh.lsus.s.l.aph.....................T................ts..s.....pah..p..csptlhps......sh.......................ph......h...h.ss.............................lh.p...................................................sssD..t.t.....F+uhhhRhhs.hh......phh...s...t....p............................thhsh.lttsupssh........tt...........................st.....hhuh.W.t.................................................................s............................................................................................................................................................................................	0	203	429	641
+434	PF03644	Glyco_hydro_85		Glycosyl hydrolase family 85 	Finn RD	anon	CAZY 	Family	Family of endo-beta-N-acetylglucosaminidases.  These enzymes work on a broad spectrum of substrates.	36.00	36.00	36.50	40.30	31.30	35.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.04	0.70	-5.30	36	655	2010-01-08 16:09:57	2003-04-07 12:59:11	8	45	559	13	183	522	4	304.40	35	29.23	CHANGED	hhusYt..ssph.......spGs.sph...sYs.FtaWphlDhFVYFS....H.....................thlslPsssalssAH+pGV.VLGT.....lhh...EhssthpphcphLp.sppus..hhh...........A-+Ll-luchYGFDG.WhlN.Essh.s.......................stspphhsFlphLpcphpp...........t...............hlhWYDu.hT.cGplpWQNtLsppNthF................hpssDuhFhNYtWst.....................................pp......lctStphApshshs.hc............lasGlDVauRu..............htuthpsptslcph.......t..psphSlulFAPuWsac.........................spFhpp-spaW.......................................shlsp...................................lsF.hTsFspGpGtpaah	...............................tsuhs..psph.............s.Gs.pp........uYs.FsaWQYlD.hVa.Wt....c..........................GlV..Psssh.l....sAu.HRNGVs..V........hG.T...........laF.............sas..s....u..h...t.....htph...L...c.....p...c.scus...asl.......................AcKLV-hA+aaGaDG.aFINpEssss.............................shspphppFhhYhpchutp......h........................................ph.WYDu.hT.ssth.aQs..u.Ls.-hNh...F................h..ss.DshFhNasWsp.................................................sp............cho.lttApth.G.ts.sa.p..............lasGl-lptsG..............hpsph..c.h...sshLcp...............t.phch....SluLF...AP...s.....hhhp.........s..................htpsatc.pEchaasGhpssPptp..................ssspsWh.Ghus.hlss+oshsu................................................sF.hTsFNsGpGhcaa..........................................................	0	71	108	148
+435	PF04101	Glyco_tran_28_C		Glycosyltransferase family 28 C-terminal domain	Bateman A	anon	Pfam-B_1105 (release 6.4)	Domain	The glycosyltransferase family 28 includes  monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.96	0.71	-4.59	34	6284	2012-10-03 16:42:29	2003-04-07 12:59:11	11	38	4635	6	1557	7997	2525	160.10	23	45.21	CHANGED	hlhVhsG.Spstp.lNphlhphtthhtpt...............................hplhhtsGts.shpthptp..htph................hsahcphsphhppA-.llIo+uGAuTlhEhhthGtPsIllPh.ptht.tH.pppthplsp.thushhhhttphs....cpLtptltchhppppp....hppspt........hpphtshhcpl	....................................................................................................................................lLl.h..GG....S...G.Ap...h..lN....p..h.l.....p...s.h..s..t.l.t.pp...........................................................................h.p.ll.a.sG..cs...php.p.h.p.pt.....htpht.....................................thph..h.s.a.....h..c.....c.........h.......s.p.h.h.........s.........t.........A.........D...l..V..lsR.u.GAsTl.sElh..s.......h.....G.....h..P...s.l...l...l...P.h.s..tt....p..t.cQhtNA.t...l.tc...tG.u..u....h..h....l.....t....p.s....p...hs..........sp..tl...h..p.t.l.t.....p...h.p...ptt.......h.th.ttt.....................hh...........................................................................	1	542	1040	1326
+436	PF00852	Glyco_transf_10	Fucosyl_transf; 	Glycosyltransferase family 10 (fucosyltransferase)	Bateman A	anon	Pfam-B_1677 (release 2.1)	Family	This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage [1]. This family is know as glycosyltransferase family 10 [2].	21.00	21.00	21.10	21.60	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.29	0.70	-5.88	49	1458	2010-01-08 14:05:26	2003-04-07 12:59:11	14	27	340	9	858	1374	288	287.80	23	74.46	CHANGED	pphhhshhhhshhhshhhhhhhh.htsssssh.t..t.............................ppphhl.LlWhaPFstphs.............hssCtphh.shss..ChlTssRshhscA...cAVlhHH+-lp.t...hssLPpt....................................RP..tQcWlWashESPops.....phsslps.lFNhThoYRpDSDIhhPYGhLhstpsttp....................hslP....pKs.......+..lVsWlVSN...astppt...RspYYpcLpcH.lpVDlaG+s............sp.lstsp...hhpslupYKFYLuFENS.lHpDYITEKLa.NsLtsGsVPVVLGPsRtNYEpF..lPs.-uFIHV-DFsosccLApYLhtLDcN-ptYhcYFpWRcphpl.....phht..htp...................hh....CpsCptlppt....pphps..hpsl.tsWah	...............................................................................................................................................................................hh....................................................................................................................................................................C..h.......p..pt..........t.......psllh...................h................h.s..............................................+....p...a.hh.ht..E..s...P......t..................h.......h....t..ha..N....h..Th.o.a......+.h.c....S....Dl.....h..s...h...t..h..h.....h...t....................................................................p.Ks..................t...hss.ah.sSs..................sp.......s.t..pt...............R.....p......a..h....p....p...L....t....ph.....l.....p......lDs.a...Gps...................................................................tt.h...s..t..tp..............hhp.h.l.s.pYKFhL....uF.EN.o.h......s...pD.YlTEKh.a...s....ul...hss.....s.....VPlhhG....p.....ssh..p..p..h.........hP..s...pS..a..I..plp..D.F.p.ssppLApalphLs..pspphY...p.Y.h...t.....W.+...tp.h....................................................................C.hC.hh.t...............................................................................................	0	422	516	726
+437	PF00982	Glyco_transf_20	TrehaloseP_syn;	Glycosyltransferase family 20	Finn RD, Bateman A	anon	Pfam-B_1035 (release 3.0)	Family	Members of this family belong to glycosyl transferase family 20 [1]. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex, [2].	19.40	19.40	19.40	19.40	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	474	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.53	0.70	-6.02	23	2717	2012-10-03 16:42:29	2003-04-07 12:59:11	16	20	1706	12	1143	2357	379	432.00	33	74.10	CHANGED	s+hllVSN+lPls...hpRps...suc..aphshSuuG..Llsshpulppp......tph..hWhGhsGlpssppc.....pspls.......ppLppcas..........shPlaLs......-chhcpaYpG......aupslLWPlFHYhhs.......ptpa-cstWpuYhcsN+hFA-plsphhp...csDhlWlHDYHLMLLPphLRcchsc......hKIGFFLHsPFPSSEIaRsLP..sRpEILcGlLusDLlGFHTh-YARHFLSsCsRlLs..................lcspss....tlcatGRplsVtuhPIGIDssphtcslppssVtp+lppL+pca.pthKlIlGVDRLDhlKGlspKLhAa.EpFLppaPEapGKVVLlQlusPoRscsc-.hpplcpplp-lVsRINucaGsls..apPlhalcc.slsap-hlALashuDlslVoulRDGMNLVuaEYlssppc...............+cGsLlLSEFsGuApsLs.GullVNPWshcclAcAlppALsMoc-c+pt+ac+ha+hlspassshWucsFlp-Lpc	.......................................................................................................................................p............................................ht...u...sG..G...Lss.u.l.shh.pt............tts.....hWhG.....W.s.........G..ss.tsp............tlt.....................t.s..p..h.s.............................................................................hhsl..L.s.............ppph...cpaYps..............................Fu..N..ssLWPlaH........Yh.................................hspa...p...c.p...tW.puYhcVNphFAcpl....hthhp.............cs..D.........h.....l.WlHDYH..Lhhlsp.hL.Rc.t..t.sp................................s+IGFFLHl..PF..PssElapt..L..P...................h+..ccl.Lc.....ullshD..............LlGFpT.s.t....ppF.lsss....p.phh.t............................................................hp.spss.........thph.....G....+....th......p....lts...aPI...GI....-s..pp..h.t.p.hs.........p...t.....s.....t.........l....tt..c......h....t.....pl..+..p...p.....h..........t......s.................h......p.l.l..luVDRLDYoKGlsp+lhAaEthL.....cp.hP..pa.p.............s..+..l.shlQ......lA..s.s....S.....R.......t...c.....l.p.........t.....Y............p....p....l+pplpphsGRING.c.a.........G...pls.........a........s.P..l.h.a........l.p....p...ph.s....h.pp...Lhulaph........uDlsLVTslRDGMNLVA+EYlAsp...ss.............................................................................psGsLlLScFAG.A.A.p.p..L...s...t..u............l............l.V.NP.............a.......Dhcth....As....Al...p...p...A...L...s....M...s.....t...E+.....tp.....Rhpphhc.hlhppsl.shWtpsFlpcLt.t.................................................................................	0	336	691	979
+438	PF01755	Glyco_transf_25	LPS_glycoyl_T; 	Glycosyltransferase family 25 (LPS biosynthesis protein)	Bashton M, Bateman A	anon	Pfam-B_1857 (release 4.1)	Family	Members of this family belong to Glycosyltransferase family 25 [1] This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyse the transfer of various sugars onto the growing LPS chain during its biosynthesis.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.38	0.71	-4.67	22	1865	2012-10-03 05:28:31	2003-04-07 12:59:11	12	20	892	0	399	1567	1071	173.10	22	55.71	CHANGED	h.thalISLcpu.cR+phhppphtp..........plsFpFFDAlsscphpp...........................p..tt.h..hhpphhhtp.LohGElGChhSHhhLWpcslcps....hphhhIhEDDlhlspph...ht..........t.tal.h.thh...a....h.h.ph.sah..shphcpp.h..............................................h..h.pthhGTsGYllo.puAcchlphh.pphh....hslD.hh	............................................................................................................h...halIs.L.tpt...p.Rhtth..ttp.htp............th.t.h...p...hh-Alsspthst......................................................t.t...h..h.......h..h.h.p........h........t.........l.o.....G.E.........lGCahSHhtlWcphl.....c...p...s..................phh..ll.hE.DDl..h..h.p.p..s.....h.....t...h.t..h..t...................t..th...lh.................................................hh.h.......................................................................................................................................................................................h.............htshuYhlo.puAphhlph.......h......hshD.........................................................................................................................................................	0	99	205	301
+439	PF00777	Glyco_transf_29	Sialyltransf; 	Glycosyltransferase family 29 (sialyltransferase)	Bateman A	anon	Pfam-B_1020 (release 2.1)	Family	Members of this family belong to glycosyltransferase family 29 [1].	20.90	20.90	21.10	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.87	0.70	-5.25	105	2130	2010-01-08 14:04:21	2003-04-07 12:59:11	13	26	197	3	993	1851	142	224.50	21	69.43	CHANGED	ss.tph..hhtppssthsp.....phhhs.hs.ppps..plspsltplhs.......t.Pht.pp...........h+pCAVVGNuGlLpsSphGpcIDsaDhVlRhNhAPlps.accDVGsKTohphhsPpsh.pp..............hspsshhhhls..hhstshhWlsuhhhpp.......sshhthhh.hhhphhhspppl.........................................hlhpP........pal+tltphahppsh........csphPS..........TGhlhlhhAlphC-c.VplYGFhs.....tsp.sh.pHYY..-phh.phht.......HshshEhthlpcL.tppG..hlchhhsp	................................................................................................................................................h...h..........................t.......................hppCA....VVGNuGhLhsSphGp.c.............I.Dp..tDhVh........R....h..NtAP.sp.s....ap.pDV.Gs+Ts..hhh......hsspsh....t.......................................ttp..h.h..h....h........hs..thh.ah.shh.pt...............................t....h..hh....h.......h...h.........h...t....p.h................................................h..h.h.p.P................thh.t...h...t.t.....hhhp..h.........................phph.o..........oGhh..h.hhhAh...ph.C-p....lplaGFhs...........pt.t...h..HYa.....-.p............t..h...................Hph.hEh.hh..ph.p.....th.......t..........................................................................................	0	297	410	626
+440	PF03360	Glyco_transf_43	Glyco_tranf_43;	Glycosyltransferase family 43	Mifsud W	anon	Pfam-B_1447 (release 6.6)	Family	\N	20.20	20.20	20.80	20.60	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.28	0.70	-4.77	15	602	2012-10-03 05:28:31	2003-04-07 12:59:11	11	9	129	16	335	571	6	196.50	36	58.65	CHANGED	LupTLppVs.sLHWIVVEDussssP.hVuslLcRoGLs..aTalst+TPpsac....t.p.hhsRGshQRNhALcalR.............ppppcGVVYFADDDNoYsLcLFp-.hRslc..+lGlWPVGLlG...........................GhhVEuPhlpss..KVluap....ssWcsc..RsFslD...........MAGFAlNlcllLp.....+ssAsFshcs.p...GhpEoshLcpLsh.chs-lEPh.ussCo...cILVWHTRTcp	...................................LupTLhhVs...sLhWlVVEDutpps......sspl...Lpp..oG.......l....asHLss.....p.s....tthp............p.h.h.sRusp..Q.R..NhALp.alR............................ppphpGV.....VaFAD..D.DNo.........YslcL.F-E......h................Rp...sc....plusWPVu.....h.lu................................shhhEuP.h.s...psu.....+Vl..Gap......................ssap.sp...R..s..FslD............................................MA.GFAlshp.llhp................................pspsh.hphps.p.....GhpE.o..sh..L..pp.ls....s.pc...l.Esh....u..ssCo.........clLVWHs+oc...........................	0	90	147	256
+441	PF01501	Glyco_transf_8		Glycosyl transferase family 8	Bateman A	anon	Pfam-B_730 (release 4.0) & Pfam-B_5903 (Release 7.5)	Family	This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase Swiss:P27128, lipopolysaccharide glucosyltransferase 1 Swiss:P27129, and glycogenin glucosyltransferase Swiss:P46976.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.73	0.70	-5.05	67	5748	2012-10-03 05:28:31	2003-04-07 12:59:11	15	52	1943	49	1770	4515	1043	233.00	18	55.72	CHANGED	slshshspsY..................................lhushsslpSllpssst...............................hthphhhhssslsscthpplpthhpth..h.......................................httphhshhsasRhhlsc.........................lh..sphcKllaLDuDllV.hpslspLaslshs.s.hhusstp...............................p....tth...t...sshFNsGhhlhshstWpppslppphhph..hphptp......h.hs-QshlshhFt................sphp.LshtaNhhshhh..................t..hp.h.ppstllHa....sG...ttKPWpphs	...................................................................................................................................................................................l.hshsts..a.......................................h.tshsh...htSlh..hp..sp....................................................hththh.l...h...s.s...t....l..s........t...p.........h....p..h...l...p....p....h..h...p...p....h....t....t....h..........h..h......s....................................................................................................ttph..h..s..h.h..s..a..h.R.h.h.l....p................................hh...sp....h.....c....+.llYLDu.D.lls....h........s..........s....l.s..c.L.......a....s....h...sht....sth...h.us....s.s.....................................................................................t...................h....t............ht..................ss.h.....F..NuG.l....hll.shp.t..h...p.....p......p....s...l...p.p....p.h...hph............hptptt....................h.hh.D.......Qs....h..L..N...h...h...ht......................................sp.h...h.....L...s.h.p..a....Nh.hthh.................................................t.......t.....h.....p..p..s...hl..lH.a........hu.........KPW.................................................................................................................................................	0	480	946	1364
+442	PF00535	Glycos_transf_2	glycosyl_transf_2;	Glycosyl transferase family 2	Bateman A	anon	MRC-LMB Genome group	Family	Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.86	0.71	-4.57	253	43678	2012-10-03 05:28:31	2003-04-07 12:59:11	21	600	5370	41	12098	45842	18220	163.70	16	45.40	CHANGED	SlllPsaNc.......tphltpslpolhpp..........................h.phEllllDDuS.sDso..hplhcphht...........plpllppsps...Ghusuhstulpt.upGc....hlhhlDuDshhtss.hlppllphhpp.ssthshsshhthttpttththh..................................hhhttttttthththhhhhsstthhppphhtphh	......................................................................................olllPs.a..Np........tph...l....t...p...s....l...p...o...l...hpp......................................................h.shE.....l....l..l.....l.....D....D......u.........S....s.......D........s....o...........hp.....l...h.pphtt..................................p.l..p...h....l.....p........p.......p.........t.......s...........h......G.......h..........u......s.......u.......h......s......t....G....l.........p......t......A.......p...uc.....................hl.h.h.l.D...u.D......s..h.......h......s.........s....s....h....l.....p....p........h....l...p....h....h......p........p.................s........h.....t.....h.....s..h...s....s....h..h.h.h...t..t.........................................................................................................................................................hh...........................................................................................................................................................................	0	4072	7912	10203
+443	PF00953	Glycos_transf_4		Glycosyl transferase family 4	Finn RD, Bateman A	anon	Pfam-B_534 (release 3.0)	Family	\N	21.40	21.40	21.40	21.70	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.31	0.71	-4.43	116	8422	2009-01-15 18:05:59	2003-04-07 12:59:11	16	18	4730	0	2028	5693	4534	172.80	31	48.36	CHANGED	hhhhh....hssh...llshlGhlDD...h.........h......slsshh+lhhphlsuhlhhh..................................shttlshhhs.................................................h.hs.hh.h.....hh....slhhlsuhh.....NAhNhhDGlDGLu.......uuhulls.hlshshls..........................ssh.hhhh.............slhu.ul.lG....FLhaN.h.P.....A...+lFhGDsGShhlGhh..lu....hlulhht	................................................................................................h..hlLhshhshshlGhlDDh............................................h.u.Lss+..hK.hhh....Qhlsullhh.hhhh............................................thstls.h.hh...........................................................................................h.h.sl.u.......h.h...hl......hl....slhhl....luhs....NAl.NL.sD........GLDGLAuusssls.hsuhullu..............................................................hht.............sphpl.sl.h...............sh..............ullG....Ah..LG....FLhaN...hhP............A....clFMGDsGSLhLGhh.luslulhh.p..................................................................	1	688	1325	1728
+444	PF00903	Glyoxalase		Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	Bateman A	anon	Pfam-B_1207 (release 3.0) & Pfam-B_5495 (Release 8.0)	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.44	0.71	-4.16	82	14717	2012-10-02 15:00:03	2003-04-07 12:59:11	20	46	3790	237	3666	25008	5991	128.70	16	62.42	CHANGED	tlsHhs........lhlsDhpcuhpFYpcs...LGhplhpphs.............................hhhhhhsssttlplhhttsssstttth.....................................................................................................................................ththhshsscDlttthcclpppG..................sphhtt.scthhsthhhh.......................hpDP.sGhhlEl	...............................................................................................................................................................ltHhs..............lhs..s..-...h..p...c..s...h..p...FY...p...cl......L....G...h.....c...l......h.cp.hs....................................................................h.h.h....h..h..h....t......s...s.....s.....s.....t......l.....p....l....s.......h.....t...........s....s...s..t.t.t.t.t...................................................................................................................................................................................t..h.u....a..h..s.........s....h...c...-.....l...t.......t...h.....h......p....p....l....p.....p...t..G..................................h..p...h....p...t........h.............s.....p....h....h....h...t....t....h...h..........................................hpDP...sG.hhEh..........................................................................................................................................................................................................................................................................................................	0	972	2122	3010
+445	PF04464	Glyphos_transf	glyphos_transf; 	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 	Waterfield DI, Finn RD	anon	COG1887	Family	Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerisation of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate  units from CDP-glycerol to the linkage unit lipid [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	369	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.14	0.70	-5.70	22	3039	2012-10-03 16:42:29	2003-04-07 12:59:11	9	50	1148	20	433	2103	385	317.90	20	61.59	CHANGED	hhhhhthhhP..hcsshllFtuhttcshusNsptlac.hhp..c.tsshchlWshcp...........tth.tssphlthsShchhhhhhcuchllss........s.hss..hhh++psphalQsWHGs.sLKphGh-..t.....h.p.....phht....psppaD...ahlossphpsphap....csFs..hstt.phlphGhPRsDsLhpspttp..httlppphslshscp..llLYAPTaRcsttt.......................hthtlDhcplh....pthtpchhllh+hH.hhsstht.........hppsshllslsstp......clp-LhhsuDlLITDYSSlhFDaulLc+PllhYs.Dh-pY...ppp.RGhYh-.a.ptsPGslscs.p-Llchlpph.ppspt.tcphphhpccasp.apDG+uScRlhphlht	...........................................................................................................................................h..h..............tp.lh..h..s.......t....t..hsss.t.hlhp...hh.......p...t..p..h...p..h..hh.hhp.........................t..th.....t..hl.....................p......h.....c....h.......h.....hh.....tp....A.c.h.hh.s....................s.h.........h..h....h..p..........p......p....h....h...lQ.........hWHus.sh.K.p.h.shs..t...............................h.h...thpph.s..........hhl.s.....s...s.p..h..t...p...h.at.........puat.......hpp...t....p....l..l...h.G......h.PR...Dhlh.....pp....p.tp.............tth...p....p..p.....h......s......l..........t..tcp..........ll.LYA..P.T..a..Rssttt..................................h.h...s..h.....p.tlt........tht.p.....sh....h..l..l.h+hH.......h...h...t..p..p.h.........................thtp.h..h..h.s.h.s.s..h..............................ch.p-..l..hhh..sDl..l.ITDY.SS.lha.-..a.h..h..h..c..+..P...h.l...a...a....s.............Dh....p...p....Y...............pp....R.s.h..h..s...h....p...........h..s.............u.....h........s..p.......s......pt.Lh.p.t....l..p..p......................................t....h............h.....hp.....t..h....hpst...p.s.spphhp....t........................................................................................................................	0	162	296	399
+446	PF00958	GMP_synt_C		GMP synthase C terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1137 (release 3.0)	Domain	GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. This family is the C-terminal domain specific to the GMP synthases Swiss:P49915 EC:6.3.5.2. In prokaryotes this domain mediates dimerisation. Eukaryotic GMP synthases are monomers. This domain in eukaryotes includes several large insertions that may form globular domains.	21.10	21.10	21.10	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.23	0.72	-4.27	161	4898	2009-09-11 08:43:03	2003-04-07 12:59:11	17	31	4651	24	1280	3535	2105	95.50	57	18.75	CHANGED	h-Elccs.......GLYcclWQuFAV.Llsl+SVGVhGDpRoYsas...................................................................................................................luLRAVpSpDuMTA-as.....c.lP.........a-hLpclSsRIlNEVpuVNRVVYDITSKPPuTIEW	...........................................h.EElppAGL.cclaQsFsV.l.h.s.V+S..VGVMGDsRT.Y-..a.s...........................................................................................................................luLRAVsohDhMTAcaA.........+l.P..........................a-lLt+lSsRIlNEVc.slNRVVYDIoSK..........PPATIEW...................	0	423	820	1086
+447	PF01825	GPS		Latrophilin/CL-1-like GPS domain	Bateman A	anon	SMART	Family	Domain present in latrophilin/CL-1, sea urchin REJ and polycystin.	21.50	21.50	21.50	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.64	0.72	-3.85	139	2565	2009-01-15 18:05:59	2003-04-07 12:59:11	16	386	110	4	1472	2317	28	46.70	35	3.56	CHANGED	tpstCsaWs..........pspusWu.ocG..Cps.hp.sst............................sp...s.pCpCsH...LT.sFulLh	.............................h.pstCsaWs......................sttGtWo..opG..Cph..hp...ssp..................................sp.......o.pCpC...sH....L.T...sFAlLM............................	0	524	628	925
+448	PF02893	GRAM		GRAM domain	SMART	anon	Alignment kindly provided by SMART	Family	The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.24	0.72	-4.45	33	2555	2012-10-04 00:02:24	2003-04-07 12:59:11	15	89	326	5	1481	2393	6	70.70	24	10.41	CHANGED	pch+.phFp......lstsEpllss......asCtlhp................ph.hpGplYlospclsFpS.hhss.t...........shslPhsslpplcKhs	...........................................................................................ap.phFt......lst.sEpLhps...........................as.CsL.p.................................ph..h..pGplal.ospp...l.sF.t..S..h.h..sp.s..............................plslPhtplpplcK..t...............................	0	338	634	1024
+449	PF03514	GRAS		GRAS domain family	Bateman A	anon	Pfam-B_393 (release 7.0)	Family	Proteins in the GRAS (GAI, RGA, SCR) family are known as  major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development [1].  Mutation of the SCARECROW (SCR) gene results in a radial  pattern defect, loss of a ground tissue layer, in the root.  The PAT1 protein is involved in phytochrome A signal  transduction [2]. A sequence, structure and evolutionary  analysis showed that the GRAS family emerged in bacteria  and belongs to the Rossmann-fold, AdoMET (SAM)-dependent  methyltransferase superfamily [3]. All bacterial, and a subset  of plant GRAS proteins, are predicted to be active and function  as small-molecule methylases. Several plant GRAS proteins  lack one or more AdoMet (SAM)-binding residues while  preserving their substrate-binding residues. Although GRAS   proteins are implicated to function as transcriptional factors,  the above analysis suggests that they instead might either   modify or bind small molecules [3].	19.90	19.90	20.10	20.50	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.25	0.70	-5.74	31	1831	2012-10-10 17:06:42	2003-04-07 12:59:11	9	14	343	0	790	1894	0	305.00	31	67.57	CHANGED	LhphLlpCAcAlss..sshp..hAptlLtclsph..uSstG.s.....shpRlAsYFsEALssRlss.....h.p.h.ssptss......sschhtuh..................ph...a.cssPhh+FuahTANpAILEAhcsp...ppl..HIIDFsIspGhQWPuLhpuLA.pRs....su......sP.plRlTGlus.t........stttLppsGpRLspFAcplslsFcFps....hsp.phspl...phptL....plps...sEslAVNhshtlH+hh.......................................................spssshtp.....thLphl+slsPclVTllEpE..ssp.Nss......sFhsRFhEuLcaYoulFDSL.css............hs.ts..ppRthlEchhlu+cIhsllAsEGsc.RhcRpEshtpWRp+htp.uGFpslsluspshpQAchLLphas.scG..aplc...-c......susLh.LuWps+sLlssSAW+	................................................hphLhtCApAltt....ts.hp......hApt.lltp..l.t.h......us.stu...s.................s.hp...+.lAtaF.scuLtt.Rlht..............................h.....stt.........................ph.h.h.....................................h........hhphs...Pah+huahsANpAIl-Ah.t.sp...................ppl.....Hl.lDa.s.........h....t......G...h....QWssLhptLu..........Rs.......sG......................PP..thRlT.uls.s...................stttlppsG.+LsphAc....p..h.t..l...F..c.aps.......................hst....ph..t..s.l.............p.....p....L.........plp..............sE.sls...VN..h.hth....+plh.......................................................................................................................sp....ss.s.htp.............hL..........phl+.th........pPc..........lhs..lsE...p-.......ush....s...s.s...................FhsRFh-u...Lp.aYushFDuL.c..ss.........................h.s...ts........tpc.hhhpp.hhuppIhsllu..s..........-..G.p.....Rh...........E.....R....Et...........h.t..........pWptph..tt..uGF.t...h.ls........sht.p.s..p..hl.t..........h....................t..........a....h.......tt............t.t...hh...tW.t...hh..osW........................................................................................................	0	78	520	682
+450	PF01465	GRIP		GRIP domain	Bateman A	anon	Sean Munro	Family	The GRIP (golgin-97, RanBP2alpha,Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. The GRIP domain contains a completely conserved tyrosine residue. At least some of these domains have been shown to bind to GTPase Arl1, see structures in [4,5].	20.50	20.50	20.50	20.80	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.90	0.72	-4.44	44	627	2009-01-15 18:05:59	2003-04-07 12:59:11	15	21	256	8	415	639	5	44.60	31	4.30	CHANGED	pshshpYLKNVllpFLppp-..t.+ppll..sVlsolLcFopp-pppl.	............tsshEYLKNVllpFlpt+..-.....tpp..p..Ll..sllsslLpFoscEpptl........	1	146	206	324
+451	PF02946	GTF2I		GTF2I-like repeat	Bateman A	anon	Pfam-B_101 (release 6.4)	Family	This region of sequence similarity is found up to six times in a variety of proteins including GTF2I.  It has been suggested that this may be a DNA binding domain [1,2].	20.60	20.60	20.60	21.00	18.90	17.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.42	0.72	-4.14	18	742	2009-09-10 22:54:23	2003-04-07 12:59:11	9	8	42	10	300	939	0	75.00	47	38.66	CHANGED	LRcpVc-LFspKYucALGhspsV.VPYpphhppPpslhVpGLP-GlsFR+PssYslspLc+ILcspcpIpFslK+P	............LRcpVc-LFspKa...u..EALGh..spsVtVPYp+hppsPpslhVpGLP-GlsFRcPssaslspLc+ILcspppI+FlIKRP......	0	17	38	98
+452	PF01018	GTP1_OBG		GTP1/OBG	Bateman A, Studholme DJ	anon	Pfam-B_875 (release 3.0)	Domain	The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.	21.50	21.50	21.50	21.70	20.70	21.30	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.19	0.71	-4.58	8	5081	2009-01-15 18:05:59	2003-04-07 12:59:11	17	23	4657	3	1432	3621	2408	149.90	46	37.77	CHANGED	FVDpscIhlpuGsGGsGhVSFRREKalPtGGPDGGsGG+GGDVlhEsDpslsTLlDaRap+HaKApsGppGtucNpsG+sGcDlllKVPsGThVhD.-ssplluDLVcsGpRhllApGG+GGLGNu+FtSssp+APpaApsGpcG-pRplpLELKl	.................................................FlDpspIhlpAGcGGsG.sl.............u...F....R......R..E...K...al..P...h.....G....G........P..s.GG....DGGcGGsVhh........s..Dc..s..l..p...TL...lD......a..R......a...p...+.+....a....+A..pp.Gps....G...t.....u......p..s......p.p..G.+..........s.......G....c..D..lhl+VPsGT....h.......V........h...............D........t.............c..................T........s........c........l.................l........uD...Ls..c..p...G.p.c.hl.lA+GGpGG....h.G..Nt.+.F.....t.....o....s..s.........NpA...P.....ch.u.....p................GpsG.-c+plhLELKl..................................................	0	493	898	1211
+453	PF00009	GTP_EFTU		Elongation factor Tu GTP binding domain	Bateman A	anon	Prosite	Domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.24	0.71	-4.86	216	69868	2012-10-05 12:31:07	2003-04-07 12:59:11	22	241	24054	243	11959	72575	19001	186.10	31	41.29	CHANGED	cphhNlullGHVDcGKTTLssplhhhsuh....t..t...t..t..............hDphppE+cRG.....ITIpsutsphp.....................................spptphsllDsPGHtD.FspphhpG..hu.hDuAlLVlsAs........cG.......stsQTccthhhApphsls......hll..hlNKhDps...........p.tchtclhcpltpph...........................................................................................lpth..hss...........................thsl.l.sSAhpuh..................slp......................................................................................................s.Ll-slsphlPs	..........................................................................................................................................................................p..st.....GKooh...h........t...t..l..h.............................................................................................................hD......h..t......E....c...p...R..G.......I..T...I...p..h..u..h..h.php.....................................................................................................htphhls.l...l..D.s...........P..........G............H.............t............D..........F............h...........t...........p...........h...........h...........p....u................hs.........s......D........s.........A..........l........L...l.....V...s..A.s..............................s.G.........................hp..s..Q......T.....+......c........t......h.........h........h.........A.........h........p.........h........G..............l................ll..V..s.l...NK.....h.Dps..........................ps.c..h..p....c..l....h...c...p...l.p......ph.......................................................................................................................................................................................................................lp.th...shsst...................................tss.h.l...h.S.....u......hp.u.....................................s.h.......................................................................................................................................p.Ll-sl.t.................................................................................................................................................................................................................................................................................	1	4102	7392	10000
+454	PF03144	GTP_EFTU_D2		Elongation factor Tu domain 2	Bateman A	anon	Prosite	Domain	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.28	0.72	-3.86	305	58968	2012-10-05 12:31:07	2003-04-07 12:59:11	20	172	19933	232	11011	44749	11474	68.00	28	14.18	CHANGED	GslssuRl.sGpl+hGsplhlh..t....t..............sclpsl.hhpt.thpps.....................hsusssGhhltshshcc...lptGpsls	...............GslsssRVpsGsl.+.s.G.ph.V..h..hh...s.s.....................................scV...p..ul..p.h...a...+.p....t...h.p.c.s.................................................ls.G.s..s..s..G....h.....l..p.s..h.s..hc-......lppGpsh...........................................................	1	3673	6761	9154
+455	PF03143	GTP_EFTU_D3		Elongation factor Tu C-terminal domain	Bateman A	anon	PF00009	Domain	Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA [1] and binding to EF-Ts Pfam:PF00889 [2].	21.30	7.10	21.30	8.40	21.20	-999999.99	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.29	0.72	-3.83	82	23082	2009-01-15 18:05:59	2003-04-07 12:59:11	12	49	16442	102	2870	18678	2585	86.00	47	25.05	CHANGED	slpsppcFcApVhlLs+.....poshhsGYpP.hah+Tsclss.hhpL.........stts......chlhsGDsshlplchhp.PlslEptt......RFAlR-GG+TVusGllpclh	..................................s+ssscFsAQ...VI.V...LNH............PGp.I.ss.G........Y...sP.V.Lc.s.H.Tu.clss.........+h..sEl....pt.h-.............sucs........................c.ltsGD..ss.h...l.p....l...........+...P.h....s...l.Eth..........................cF....................................................................................	1	948	1617	2282
+456	PF01493	GXGXG	DUF14; 	GXGXG motif	Bashton M, Bateman A	anon	Pfam-B_428 (release 4.0)	Family	This domain is found in glutamate synthase, tungsten formylmethanofuran dehydrogenase subunit c (FwdC) and molybdenum formylmethanofuran dehydrogenase subunit c (FmdC). A repeated G-XX-G-XXX-G motif is seen in the alignment.	19.80	19.80	20.60	20.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.42	0.71	-5.32	29	4251	2009-09-11 14:28:49	2003-04-07 12:59:11	14	50	3290	15	1375	3769	3934	186.10	39	14.86	CHANGED	hphslhsscRslssclsstls+thGpps.h...............sslplphpGoAGpShGuahssGhp.............lplpG-AsD..alGpuhsGGcIllpsssss...........shtsspsshhGssshaGATGGplahpGpAG-Rhul+N...........SuuphVlEGs.GsassEYMsGGhllVLGcsG..........cNhGAGMoGGhsYlhsc.s..............shspphshchVchp...plps...........tstppL+tl	.............................................................h....ltNssRsl.Gshlustl...sc..p.aGppG..L..........................s.t.s.slplph..p..G.o..A..G.Q..S.F.G...u..a.h..s..t...G.l.p.........................................lplpGDA.ND..YVG.K.G.h.uGG..pll.l.p..Pshss.............th.s.pcshIhGNs.sh.......YG........A..TuG.c.la.hp.Gp.A..G..E..RFuVRN...........................SGApsVVEG................s.G..D......a..uCE.YM........T........GGhVllLGp..sG....................pNFu...AGMoG.GhAYVh-pss..............ph.t.t..p.s.N...chlph............lpt..................h.....................................................	1	407	886	1167
+457	PF02756	GYR		GYR motif	Ponting CP	anon	Ponting CP	Motif	The GYR motif is found in several drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues may suggest it could be a substrate for tyrosine kinases.	20.60	20.60	20.70	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.19	0.73	-6.39	0.73	-4.01	4	377	2009-01-15 18:05:59	2003-04-07 12:59:11	9	37	13	0	227	370	0	17.80	73	19.15	CHANGED	-DGY+YKTVRRL+hRhRH	...DGYcYKTVRRLKaRpR+..	0	34	34	134
+458	PF03457	HA		Helicase associated domain	Yeats C	anon	Yeats C	Domain	This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices.  The function of this domain may be to bind nucleic acid.	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.41	0.72	-3.87	186	906	2009-09-13 12:23:34	2003-04-07 12:59:11	9	52	116	1	382	984	370	69.10	24	38.11	CHANGED	hss...hpppWppta.ptLppatppcG...p..tp.lPpsh....................shpLGpWlppQR....pth+p..................sp......Lst...-+hptLspl..shh	.............................pttWpp.ta.ptLppatppcG.................p...hp..lPp.sh..t.....................shtLGpWlspQR.............pphcp....................................................up............Lss......-RhptLcplGh....................	0	258	341	371
+459	PF04408	HA2		Helicase associated domain (HA2)	Bateman A	anon	Bateman A	Domain	This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.	21.30	21.30	21.30	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.36	0.72	-4.00	140	7005	2009-01-15 18:05:59	2003-04-07 12:59:11	18	172	2406	5	3299	6442	376	102.00	28	9.96	CHANGED	pulphLhtLGAL..........st....ps.................pLT.tlG+phuphP.l-PpluKhL..l.husphsC.........hcchlsIsuhLos.pssFhp..............................s.t.tttsp.........................................................t..t+tph.............ps.........DalshL	...............................................................................t.AhphLppL.GAL.........................ss......ps.......................................................pLT..slG...+ph...Apl...P....l.....-P+L..u.+.Ml.......l..t.u...t....p..h......s..C.................................hpp..sls...IsAhL..oh....ps..sh.p.................................................................................................s.t.t.pt.tsp............................................................................t..h+.th....................................uDhh...............................................................................................................................................	0	1063	1774	2655
+460	PF04774	HABP4_PAI-RBP1		Hyaluronan / mRNA binding family	Kerrison ND	anon	Pfam-B_2044 (release 7.6)	Family	This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1.  HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo.  It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan [1]. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability [2]. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.94	0.72	-3.54	39	511	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	219	0	289	525	1	99.40	26	29.83	CHANGED	s+RpFDR+SGosRu..............s-..KRpGuGptNWGosp--.h................sph.-.s.ss.t-ps.ssEp.s.....t-cs........scEssscptt...Epc..sKEMTL-Ea.KsLp-Kp+uh.s...hph.cctcss	.......................................................pRta-Rp.S..G.os+s................tp.K+tG......uGttNW.GsspD-..l..........................sc.h.....-ps....s..tp.cs..s.....t....tEpts..........tppt............sppptspt.t.....Ept......spEhTL-Ea.Khhpp.pp+s.h.t...hphcc.t.............................................................	0	102	154	221
+461	PF02183	HALZ		Homeobox associated leucine zipper	SMART	anon	Alignment kindly provided by SMART & Pfam-B_1492 (Release 7.5)	Family	\N	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.13	0.72	-4.24	69	597	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	81	0	280	618	0	43.70	38	16.66	CHANGED	KQLE+Da-hLKpsa-sLppc.-sLppEppc.L+uplhsLppphttp	....KQhEhDh-hLKcsa.-sLpp-sc.......pLp+E.......hpc.L+A.hht.p.h....t..........	0	43	169	230
+462	PF00672	HAMP	DUF5;	HAMP domain	Bateman A	anon	Pfam-B_113 (release 2.1)	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.25	0.72	-3.79	222	60876	2009-09-13 11:30:41	2003-04-07 12:59:11	20	935	4667	65	16414	49005	5371	70.40	19	12.75	CHANGED	hh.hhhhhslllshhhshhlspplhpPlppltpssppl.u.p...........G...cl...s.............s.h......ttsElupLupuhNpMtppLpp	...........................................h..hhhhhs.l.l.l.s..h.....h....h..s...h....h....l....s.....p........p.........l.......h....p........P.....l....p....p....l.t....ps....s....p....p.l..u..p..........................G............cl.......s..........................................................ppl.......shp...sp..c..E...l.up...Lu....pu...h....Np.MhppLp.t.......................................................................	0	5121	10085	13473
+463	PF04849	HAP1_N		HAP1 N-terminal conserved region	Mifsud W	anon	Pfam-B_4571 (release 7.6)	Family	This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear [1-3]. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34 [4].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.93	0.70	-5.48	8	271	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	86	0	153	239	0	249.20	44	35.16	CHANGED	hppp...............lssaulRADsltsa-.............ps-Wt.osthusstp.slos.phppsL+ah..hLCssRssQMTK.TasDlDulhpLLEE................KERDLELAARIGQSLLKpN+sLp......................EcN-tLEEpL..............................ppsh-plsQLRHELshKDELLQhYos..ssEEuEsESssossh..........................+.pcupstspph.pL-sLQcKLKpLEEENppLRpEAs+L+pETh..ThE-KEQpLlpDCV+pLc-ustQluuLoEELupKoE-hsRQQEEIo+LluQIVDLQ+KsKpaulEsEELpppLsuuK-uQcQLpAE.......LpELp-KYtEChtMLtEsQEElKsLRs+s	.........................................h........................................................................p....tt.h..h....lLsspRVtQMTK.T.YsDI-sVT+LLEE........................KERDLELAARIGQuLLc+NpsL.p..........................................................EpN-hLEEpl........................................................................................tphh-plsQLpHELshK-ELLphhopss.-..-u-s-usssp.h..........................................h..t...s....pthhpL-.LQcKL+pLEE...ENh.LRs.EAspLcp-T...shEEc.EQpL.ltD.C..VcpL...p..-uN.QhsploEELutKs--hhRQQEEIopLluQll-LQp+h+ths..hE....pEELhtpLtus.K-sQ.pp.L..shE................................LpELp-+.tEshthL+EuQEElKpLRp+..........................................................	0	29	43	97
+464	PF02184	HAT		HAT (Half-A-TPR) repeat	SMART	anon	Alignment kindly provided by SMART	Family	The HAT (Half A TPR) repeat is found in several RNA processing proteins [1].	21.00	21.00	21.20	21.00	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.16	0.72	-7.40	0.72	-4.20	3	422	2012-10-11 20:00:58	2003-04-07 12:59:11	11	23	237	0	304	452	7	32.20	46	6.81	CHANGED	KEIDRARuIYERFVaVH.P-VpNWIKaARFEEc	.......Eh-RARsIYE.....R......a....l..h....V.H.Pc.lcsWIKYA+FE......	0	108	161	234
+465	PF02518	HATPase_c		Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	SMART, Griffiths-Jones SR	anon	SMART	Domain	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.30	0.72	-4.35	659	129386	2012-10-11 19:05:54	2003-04-07 12:59:11	21	5116	7141	397	36085	119054	19749	113.50	24	18.95	CHANGED	sstttLtplltsllsNAlchs.tt................splplplptpt.................................................................tphplpV...pD..................s..Gh...Gls..............................p.htplhp.hhphp......................t.tthsG..pGlGLslspp.lsct....hs.Gp.......lphpsp.......................................spGop.hpl.....plsht	................................................................................................................................h...ttlpplltNL...l..s...NA...l....c....astst..............................................spl..p..l...p....h....p...p..p.t............................................................................................................................................................................tp..l..t.l..p......V....p.D...........................s...Gh....G.l..st.....................................................................................................c.t.h..t...p...l....F...c......a.h...pspt.........................................th...s.G.........sG....l....G......L.u.....l....s.....c..p....l.s..c.t.........h...s.....G.p..........l.p.l...p.u.p.........................................................................sp.G.op...hplplP..t...........................................................................................................	0	12473	24121	30935
+466	PF00955	HCO3_cotransp	Anion_Exchanger; 	HCO3- transporter family	Croning MDR, Finn RD, Bateman A	anon	Pfam-B_1004 (release 3.0)	Family	This family contains Band 3 anion exchange proteins that exchange CL-/HCO3- such as Swiss:P48751. This family also includes cotransporters of Na+/HCO3- such as Swiss:O15153.	19.70	19.70	20.00	20.10	17.80	19.20	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.61	0.70	-5.84	18	2233	2012-10-03 01:44:59	2003-04-07 12:59:11	16	22	295	7	1138	1987	18	300.50	27	52.48	CHANGED	sLpRTGRlFGGLIpDlKR+hPaYlSDhpDALssQCLAAllFIYFAsLSPAITFGGLLG-tTcshhGV.E.llSTAlpGllFsLluuQPLlIlG.TGPlLVFEchhFsFCcspsl-YLshRlWIGhWlshlsLllVAhEuShLVRaITRFTpEhFusLISlIFIYEohtKLlclacsaPlptsa.............................................t.hsht.hshtps..hsuhhhsssssh..tstPNsALhSllLhhGTFhlAhhL+cFKNS+FFPuplR+lIuDFuVsIuIllMlhlDahls.shTpKLpVPsshpsTsss.RGWaIsPh...ss.PhWhhhAuslPALLlhILIFM-pQITslIVs+KE+KLpKGuGaHLDLLllulhhulCulhGLPWhsAATVhSloHlNuLpl.ScssAPGEpPchhtV+EQRVTGllVhlLlGLSllhsslL+hIPMsVLFGlFLYMGVoSLsGIQl................a-RlhLlhMPsKapPDhhYlR+VpshRhHLFThI	...........................................................................................................................................................................................................................................................................................................................................t...h...................s................................h...............................h..h...h......h................a..h.hhh.sh.t.....h.h..h.p....tc.hs.h.sh.hh..s........................................................................................................................................................................................................................................hh.....................h...h.ths...................................................................................................................................................................................................................................................................................h.hlhhh-...........t.ls........hh.t...t.........h.......ps..........sh.th..sh.hhhs............h.shhu.hP.......................................t..............................................................................................................................................................................h...............EpRhs.....hh...........h..h.........................h..............l...t..h....P.s..........hh.GhFhhhu.....h.s.....h........................h........h.........................................................................................................................	0	277	517	835
+467	PF01966	HD		HD domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	HD domains are metal dependent phosphohydrolases.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.83	0.71	-4.10	154	24448	2012-10-01 20:28:14	2003-04-07 12:59:11	17	317	4881	70	6755	26042	7473	120.90	18	28.53	CHANGED	hhpHslpVstlsttlutphs..........................p.thhhhuuLLHDlu+sh..p............................Hshhutphlpphtt...................lhphltpHppth........................................................hshtstllphADtlpsh	.................................................................................hpHolp..V..h.p.h.u..t.t...l.u.p.phs.......................................................................s.h...p.l...l...t...h..A...u....L...lHDl.G..+.....s....h....hs.c...................................................................h..t...H.s...h..u...t....p....h...h..p.p.h.t..t..h.............................l...h.....p..hl..t..t.H.p.tth.t....................................................................................................h..........t.h....l.lthsD.ht..h............................................................................................................................................................................	0	2723	4803	5965
+468	PF00271	Helicase_C	helicase_C; 	Helicase conserved C-terminal domain	Sonnhammer ELL	anon	Published_alignment	Family	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	20.90	11.60	20.90	11.60	20.80	11.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.48	0.72	-4.12	480	89228	2012-10-05 12:31:07	2003-04-07 12:59:11	26	1286	6190	172	32236	78491	16395	81.30	23	8.77	CHANGED	phhpttshpshhlaG...................shspppRpphlppFpsspt...................................plLluTslsupGlclsslshVl.h-h....................shs.pp...........hhQphGRsuRhu	................................................................................................................................t......th..t.h.h.h..l..cu..................................................p.h..s..p...p....p......R....p.......p.......h...h....p...p....F....p....p..s.ph...................................................................................................................pl.L..l..u.......T....s...........l....h.....s....p...........G.....l.........c..l.........s.........s..........l.......s........h.........V..l.......h..ch.....................................................................sh.s..hps.....................h.h.Q..p.......h.....G...RsGRs..........................................................	0	11050	19238	26835
+469	PF02602	HEM4		Uroporphyrinogen-III synthase HemD	Bashton M, Bateman A	anon	COG1587	Family	This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea.  This enzyme catalyses the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O.  Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with Pfam:PF00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway [2]. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease [1].	27.50	27.50	27.80	27.50	27.20	27.40	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.59	0.70	-5.12	137	4602	2009-01-15 18:05:59	2003-04-07 12:59:11	10	22	3824	15	1293	3545	2287	221.40	21	70.07	CHANGED	sphspt...l..pphG.hpslhhPhlc.hts..........t.ltthh.ptht...phchllhTSssuVch.hhp.h...........................t..hphht....shplh.uVGppTupslcp...h.G......hps.h.....hss.phsu.csL..hp.hltt..........thts.pp...lLh.....hpuphs..pstlh..ptL.p.....ptG..hplpplh...sYcs......t......................httphhphlpp..tph..........cslshsSspsscp.hhphhtt...........hhpshplsu.IGssTucshp.chGhps.....hhu..cpsshcul..lp	...............................................t..h.thl.pt...h.G..hts...hth...Phlc.hps.......................t..t.l.p.ttl.....t.....t.......l.............................phchllhoSts...AVchhhphhp............................................................t...th.ph..t........sh.p.h.h..ul.GpsT.Ap..t.L..cp.........h..G.........hps.th......................hPp....p.tsu..-sL....lp..tltt................................phss...p+....................lLl...................hcustu............pph.ls.......psL.p.....................ptG.....h.p.Vpp.h....sYpp........t...............................htpht.p.t.hpp.....tph......................................ssl.shoSupslps....h.hphhsp.................................hhppspl..hs..lG.psActh....p...p....hG......h..p.s.........h.h..s..pp.s.tulh.t...................................................................................................	0	418	849	1111
+470	PF00173	Cyt-b5	heme_1; 	Cytochrome b5-like Heme/Steroid binding domain	Bateman A	anon	Bateman A	Domain	This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors such as Swiss:O00264 [1,2]. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases.  There is no known ligand for this domain in the chitin synthases.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.61	0.72	-4.18	210	5879	2009-01-15 18:05:59	2003-04-07 12:59:11	23	159	836	98	3763	5749	252	82.90	25	17.81	CHANGED	haohpElpcHs...........spcssWlllcG.+VYDlTp.FlccHPGG..............tcslhttAGpDsT-tF...................................................ssh...Hu..spA+phLcp...ahlGplt	............................hohpEltp+s............pppsh.al.s.l....p..G.......p......VYDlTp...ah..p....p.....HPGG.......................................tphl..h..p...h..A.......G...c...Du.Tc...t.F..........................................................................................................t.th.....Hs.......ph.h...p.p..hhpp.........hhlGpl.h...................................................................................................................................................	0	1318	2157	3127
+471	PF01814	Hemerythrin		Hemerythrin HHE cation binding domain	Bateman A, Yeats C	anon	Yeats C	Domain	Iteration of the HHE family ([2]) found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain ([1]) in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organism from toxicity ([3]). However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands ([4]). In Staphylococcus aureus P72360 has been noted to be important when the organism switches to living in environments with low oxygen concentrations ([4]); perhaps this protein acts as an oxygen store or scavenger.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.79	0.71	-4.00	189	6352	2009-01-15 18:05:59	2003-04-07 12:59:11	18	141	3149	37	2104	4919	320	127.90	17	51.44	CHANGED	shhphlpppHcpltphht.....plpptssph.....................htthtphhpplhp....hptHhptEEph......l.....aPhhp..................thtt.h.pthpp..-H.....cphtph.lpplpphhppht............................tthhphhpthhphltpHlppE-..phlhshh	...........................................................................................................phlpppH.p.tl.t.c.hhs...........pltphhsph.......................................hptl.t.p.h.h.p...t...lhp...........h.p....t.H.h.p.p.EEph......h......aPhlp............................h..tt...h...pthpp......cH...................................cphtph.....lp.pl..p.phhp.shs..............................................p.th.hp.t..h....p....t.h...h..p.h.l.h.pHlthE-phhh..........................................................	0	719	1432	1824
+472	PF00353	HemolysinCabind	hemolysinCabind; 	Hemolysin-type calcium-binding repeat (2 copies)	Finn RD, Bateman A	anon	Prosite	Repeat	\N	20.30	5.80	20.30	5.80	20.20	5.70	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.88	0.74	-7.19	0.74	-3.06	305	35811	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1002	944	173	11803	38527	14276	17.60	43	19.13	CHANGED	hGusGsDplhGusGsDhl	..............GusGsDt.LhGGsGsDhl..........	0	2356	7679	9410
+473	PF00132	Hexapep	hexapep; 	Bacterial transferase hexapeptide (six repeats)	Sonnhammer ELL	anon	Prosite	Repeat	\N	20.60	16.00	20.60	16.00	20.50	15.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.13	0.73	-8.23	0.73	-4.23	216	70883	2012-10-02 11:29:45	2003-04-07 12:59:11	19	311	5065	687	17837	54606	32792	35.10	23	25.26	CHANGED	sshIGpsshlsssshlhssspIGcsshlusssslst	.....................shlGpsshl..ss..s..s..h.....l....h.....s...s....s.....p....I.....Gcs...s.hlusssslt.....................	2	5663	11374	14981
+474	PF03129	HGTP_anticodon		Anticodon binding domain	Bateman A	anon	[1]	Domain	This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases [1] it is probably the anticodon binding domain [2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.87	0.72	-4.04	116	17881	2012-10-02 17:25:11	2003-04-07 12:59:11	15	90	4984	142	5154	13645	6909	92.50	22	17.01	CHANGED	pVhllslsp...........thh.....phstcltppLppsG.............lpsphD..pspplG..t+hccs-hhGlPahlllGpc-l..p.........p..splsl+pR....sst.cp.....h..plshsclhph.lpph	..................................................plhllslsp..............pht......phA.pc...l.....h...p.p.L...p.p..t..G...............................lc.l...p...h....D.........c...s......c....ph..G.....h+..h+.c.s-.h.h.shP..at..l....l.lGcc-l..p....................................s..spVsl+..pp..................pst...-p..................t....pl.sl..s.c..lhphl...t.................................................	0	1742	3245	4321
+475	PF03578	HGWP		HGWP repeat	Bateman A	anon	Pfam-B_220 (release 7.0)	Repeat	This short (30 amino acids) repeat is found in a number of plant proteins. It contains a conserved HGWP motif, hence its name. The function of these proteins is unknown.	20.40	20.40	20.40	20.60	19.40	20.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-7.27	0.72	-4.63	91	1454	2009-01-15 18:05:59	2003-04-07 12:59:11	10	26	5	0	1162	1453	0	27.60	65	31.14	CHANGED	AhsA.ADWChRLHGW.lhPPLL....GV..as.FTs	..........A.sA.ADWChRLHGWPIM.PPLL....GlYs.FTs...............	1	0	0	1
+476	PF00633	HHH		Helix-hairpin-helix motif	Bateman A	anon	Prosite	Motif	The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA [2]. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain [5].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.31	0.73	-7.19	0.73	-3.96	104	8740	2012-10-03 02:11:09	2003-04-07 12:59:11	18	51	4519	41	1840	8454	3232	29.70	42	10.45	CHANGED	phpshhssoh--LtslsGlGttpApslhph	...........t.asGplPpsh-pLhsLPGVGcpTAsslhs.......	0	624	1195	1556
+477	PF01079	Hint		Hint module	Finn RD, Bateman A	anon	Pfam-B_766 (release 3.0)	Family	This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module. 	29.70	29.70	29.70	29.80	29.50	29.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.45	0.70	-5.14	46	484	2012-10-03 10:25:13	2003-04-07 12:59:11	15	23	195	12	241	449	25	193.60	31	44.69	CHANGED	uEs.......SsA.A+oGGCFPGsupVplpsGtpK.lp-LpsGD+VLA...sD.ssGpllaS-VlhFlDR-s......pppcpFhsIcT-ss.cplsLTssHLlFVucsp................ssss........................pssFAucVpsGphlhl........psssptlpsscVhclst.ppppGsYAPLTspGTlVV-sVlASCYAllcscsLAHhuFuPl.Rlhpt.........................ltshhhs..................................st.pppG.......lHWYuplLYpluphlLs	.........................................................pts.GC..FP...usup.VplpsG.tp+hlc-L..psGD+VLu...hs...tpG..p.h.h..aScll...h.Fl.DR-.s...............p...t..p.ptFhsl..c...T......c...........s..s....cpLtLTs.sHLlasspps.......................sts.........................................pshFAsclpsGpplhs.......................sssttlhsspVtp...........l....sh.....t...pt....hG.hYAPLTtpG.ollVssV.lASCaA......hlp.......ppthuphsahPh.Rhh..t.........................h...............................................................................................................................................	0	86	134	190
+478	PF01634	HisG		ATP phosphoribosyltransferase	Bateman A	anon	Pfam-B_1142 (release 4.1)	Family	\N	25.50	25.50	26.00	25.50	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.92	0.71	-4.66	18	3683	2012-10-03 15:33:52	2003-04-07 12:59:11	13	11	3572	24	1021	2521	1995	161.50	36	61.55	CHANGED	l+stDIPtaVtpGtsDLGIsGhDllpEpp.....ts....VppLh-LsFGpC+LslA.lPps.t..h..pssc-ls..........thRIATpaspLsccYhccps.......................hssclhhlsGSlElu..PtlGlADuIlDLVpoGpTL+tNGL+.I..-slhc.SoAtLIss+ssh..cppcs..hlppllsRlpuVl	...................lRssDlPsaVtpGssDlGIsGcDlLhEpt.............ts....................hhp..lh..cL.....sF.....G.....t.....C.......+.....h.....sl.A.sPps......ts...h......ps..tslt............ttRIATpYPpls+cah.s.p.cG.......................ls.s.c.llp.LsGS.VElA.............P.h...h...GLADuIsDlV...............sT..GsTLcANGLc.l..-sIhc.SpApLIss...cssh.......pp..cpp...hlcpll.p+lpsh..............................	0	333	672	875
+479	PF00512	HisKA	signal; 	His Kinase A (phospho-acceptor) domain	SMART	anon	SMART	Domain	Dimerisation and phospho-acceptor domain of histidine kinases.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.08	0.72	-3.98	265	79834	2012-10-11 19:05:54	2003-04-07 12:59:11	20	3878	5148	22	22919	67684	10793	67.20	24	10.76	CHANGED	tppphlusluHElRoPLsulhshschLpp.................tphstpp..................pphlptltppspc.ltpllsclLphu+hcss	......................................hpphlusloHE......LRTP....L...s...s....l....h....u...h....s..c....hltp........................................tthsspp..........................................pch...l...p...t...l.t...p...p...s...p...c..lt.p.l.lsclLshu+hpt......................................................................................	0	7780	15044	19599
+480	PF00850	Hist_deacetyl		Histone deacetylase domain	Bateman A	anon	Pfam-B_343 (release 3.0)	Domain	Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism.  Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins [1].	20.40	20.40	20.60	20.70	20.30	20.30	hmmbuild  -o /dev/null --hand HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.46	0.70	-5.13	148	5457	2012-10-01 22:40:15	2003-04-07 12:59:11	14	64	2207	138	2589	5145	3452	289.40	27	65.04	CHANGED	H....................st......s.HP.Ess.....pRlpt....lhptLtp......s.s.........lh.th......................................................................sp.ss.pppl.t....tlH............................................................stpY.lppl......................................................pptt.pt..tt..................................................st.s.h................sstshpsu.....hhusGuslpAsc.tlh.....ps..........................................................t...cpu.....asls......RPPGHHA.p............................................t................................................................................................................sp............ut.....GFClaNslAlAAphh....................hp...hs.hp...RVhIlDhDVHHGsGTpchFh...............................................s................c.................spVhhhSlHp....s.....t..aP.....oGhh.pch.G..................................................................ttutu...tslNl.PLss........s..........ssDpsahphh...........pp.hlh.sh...hpp...............................F.pP..-llllsAGhDuttsD............sluph.slo.................spuatph...schlhphuptht...l.lhllEGGYsh.pslupsstthlpslh	.............................................................................................................................................................................................................hhh..............t.HP..pstRlp.........hhp..t..Lht...........t..s...lhtph....................................................................htsp.As...tpcl....t...hh..H............................................................s.tc.Ylphl................................................................................................................................pphp....tt.tt...........................................................................stss.h.........thhc.t.s........thusG.usl.tus..c.tlh........p.s........................................................................................................................................................................................................................psu.....h.uls..tsshHHA..p..........................................................t............................................................................................................................................................................sp..............us............G.F.Chh...N.s.lulAhphh....................................................hp..........t..hp....RVhll.Dh.............D...lH...HGs..GspphFh........................................................................................................s......................................c.................scVhhhSh...Hp................................................tthaP........ssG.th.p-h..G......................................................................................t.u.s...............hslNl..P.Lss.....G.....................hsD...t.sa.h..p.hh..........................cphl....l....hp..t....................................................F...pP...-hllls..........sGh.....Du.htsD................................Lu.p...h..s..lo..............................................p.s...as.p.h........sphl.hphu.........................................llhl...ht..GGYsh....pslspshth.ht...h..................................................................................................	0	894	1512	2100
+481	PF00010	HLH		Helix-loop-helix DNA-binding domain	Eddy SR	anon	Unknown	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.60	0.72	-4.27	164	13830	2009-01-15 18:05:59	2003-04-07 12:59:11	21	125	1653	43	7025	12625	9	53.50	29	14.63	CHANGED	pRpttsthE+pRppplNpsh.ppL+phlPp.s......................................tspK.lsKsplLchAlcYIppLp	.................................+.t+s.h...hE.R.......p..R.R......p.c........lNpt.......h.p.....p.L.+pl..lPp..s......................................................................................................................spK..h.....s....K..sslLct.AlpYlppL.........................................................................	0	1550	2941	4943
+482	PF00403	HMA		Heavy-metal-associated domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.90	0.72	-3.82	73	19664	2009-01-15 18:05:59	2003-04-07 12:59:11	21	116	4700	120	6028	15739	1631	61.20	26	16.34	CHANGED	phtl.shsCssCspplppslppl.sGV...pslplshts.pplslph....sss............pp..lhptlp........p...huap	.................hplpGM.oC.u..u.Csppl-c.sLp.p........l...s....G..V..............pp.s..p...V....s..l...s...s...p..p.....s..pV.p..h..............sssh...........................pp.....lhpslp..........p....hGa..........................................................	1	1678	3706	5056
+483	PF00368	HMG-CoA_red	HMG-CoA_red1;	Hydroxymethylglutaryl-coenzyme A reductase	Finn RD	anon	Prosite	Family	The HMG-CoA reductases catalyse the conversion of HMG-CoA to mevalonate, which is the rate-limiting step in the synthesis of isoprenoids like cholesterol. Probably because of the critical role of this enzyme in cholesterol homeostasis, mammalian HMG-CoA reductase is heavily regulated at the transcriptional, translational, and post-translational levels [2].	17.10	17.10	17.80	17.30	16.70	16.40	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.14	0.70	-5.80	116	2199	2009-01-15 18:05:59	2003-04-07 12:59:11	13	21	1868	100	595	1829	689	348.70	33	68.69	CHANGED	pculphRRphlp...phsstp..........................................lppls.tshDhp.....................................shspshENhIGhlplPlGlAGP.lhlsGct........ahlPhATTEGuLVASssRGs+slstuG.Gspstlhp-uMoRuPshth.....sltcAtphtpWlp..cshpplcphup.....sTopau+Lpclcs.hl.......sGphlalRFthsTGDAMGhNMlopusEtshphl....pcph..ss....hphlulSGNhssDKKsuslNhlpGRGKpVsAEshlst-llpp.hL...+ssscslsc.lsht+NhlGSAhuGuh...GaNAHhANhlsAlalATGQDsAplsESSpshThh-sp.ss...............-LhhSlThPoltVGTVGGGTtL.ssQptsLclLGlp.ss......sAppLAc.....IlAAsVLAGELSLhuA......Luuscls+uHhpLs..R	..........................................................p......Rhthlt........t..t.p..........................................hp.h.......pths..p.....................................lhs.phhENslGhhtlPlGls.ss.lh..ls.Gpp.........................YhV.PhsT.pEsul...VAusspGuKhlp.t...........u..G....G.hps...............hlhp.c.tM.htps...............slt.....slsc....s.t.p.h.p.thlp......pphpp..ltp..h.ss................hspRtGthpclps..ph................................ts.p..h..l.h..lcht..scTtDAMGtNMlsphhEslhsh.l....pp...h..ts.............tl..huI.uN.aso-....................phVssp.stI.shchl.pc.hh......c.s...scpls..c.lsh.spphstss.htA..h...saNtthhNslsAlhlATGpDhtsl.tu.upuh.st.h.-uphpu.............................tpLhsslolP.l..luTVGGuotl..PhtptsL.clLGst..............sAcpLAp.....lluussLAtphuhhpA......Lsu...stltpuHMpLp...................................................	1	177	339	495
+484	PF02301	HORMA	MAD2; 	HORMA domain	Bateman A, Mian N	anon	[2]	Domain	The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.	20.70	20.70	20.90	20.80	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.31	0.70	-4.85	95	975	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	319	45	638	916	11	183.40	20	60.33	CHANGED	o.ptStpllpchlphul..............ss...........IhYhRG..........laPscsF..pphchh...............................................s......sspss...plhp.alpp...tlh-hLppp..........hlpplslsIh................ttc......slEpapFslph.............sp................................................................hstpphppplps..........llRpls.shsphL..s.L................ct...shshclhhas...........................s...........-...hpsPh.chsps.................................p...hhss..pphpltshsTshH	............................................................tshthlpchhphul..............ps...........ILY.Ru.................lYPt...psF..pph..ph.h..........................................................................................................hspssplhp..alpp.......tltch.lppt.....................hlppl.slsIh.....................ptp...................slEpapFchph..............tt......................................t...........................................................................t.t.hs..p..plppplps...........ll+p..ls.sts.p.h.L..s.L......................ct.......h..shplhhas............................................s...........s.hpssh...p.tpp.............................hphtthts.......................................................................................................................................................................	1	196	321	493
+485	PF00104	Hormone_recep	hormone_rec; 	Ligand-binding domain of nuclear hormone receptor	Sonnhammer ELL, Griffiths-Jones SR, Bateman A	anon	Prosite	Domain	This all helical domain is involved in binding the hormone in these receptors.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.13	0.71	-5.20	86	7507	2009-11-03 19:52:29	2003-04-07 12:59:11	25	75	533	1034	3461	7141	2	187.90	19	41.59	CHANGED	phhp.ptpppph....phhpthshpphh.phhppp...hhtsscahpp.hstFp.pL.shp-ph.tlLcshahhhhhlphhtpss...........htppphhhssstth.hhphpph......................th..c.lp...........hhpphhp.phtpL.ph....sphEhshhhshlhaph.....stpphp.......chpc..h.scphpptlsssLccYh............pthphsp....................stRlscl..lpllstlp............ph...............hphhpp..................hplscla	....................................................................................................hh.....................h.tphs..phh.sp.t...lht.hlcaAKp.lP.s....Fp...pL...sh..........pD...............Q............l...tL....L.c...s..sh.h.El....h.hl....t.hshp.h...............................................tpst.lh.h...s.s.s.hh...h.s...p.p.phpph.............................................h.hhp.hhp..........................................................................hhh.ph..s....p...php.pL..pl......sppEhs....h.l.p.AllLhss........................s.t..slp...............................pspp.........lcp...lp.cp..h.hps.Lppah....................ptt.t...t..p................................................................t+h..s..cL..lhhls...tl+........ph..........s..h.t...................h......................................................................................	0	821	1092	2529
+486	PF03241	HpaB		4-hydroxyphenylacetate 3-hydroxylase C terminal	Bateman A	anon	Pfam-B_3148 (release 6.5)	Family	HpaB Swiss:Q57160 encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli [2]. HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This family also includes PvcC Swiss:O30372 may play a role in one of the proposed hydroxylation steps of pyoverdine chromophore biosynthesis [1]. 	25.00	25.00	59.60	31.30	22.50	20.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.80	0.71	-5.48	87	994	2012-10-01 23:33:27	2003-04-07 12:59:11	8	3	749	14	219	738	251	197.20	33	41.46	CHANGED	chssthh.ps.uhhphhsapu.sRhul+h-hlhGhutths-ssGs..schptVpp+luEllthtEhhhuhshAsttpuptt...sGshhPsh.hhpss+hhhsphhs+lhcllpcluuuullh..lPSps.Dhpss........-ltshl-+Ylpus.shsuc-Rl+lh+LhhDhssopauuRpphaEhahuGss.th+.htlhpths..hpsttchscphhsh	..................t.hspthh.cs.uhh+hhshQuhsRhuVKhDFlhGlhtpsh-ssGs..scaptVQscLuEllshpphhaAhu..uhsscup.h....hs...........G..salP-hthhpshRhhssphY.s+Ipcllcchsuuullh..LPSps.Dhp.sP........plsthLsKYl+Gstuhst.cRlKlh+LhWDhhuSpFGuRa.plYEhpauGs.pph+.hph.hpphp...tssphchhhshsp........................	0	82	138	182
+487	PF02185	HR1		Hr1 repeat	SMART	anon	Alignment kindly provided by SMART	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.42	0.72	-4.23	106	1359	2009-01-15 18:05:59	2003-04-07 12:59:11	11	60	288	5	738	1202	2	69.40	23	12.45	CHANGED	ptlpplpcclphEhpl+pGuEshh+h......sssppp...........hppspsplpcopp+lphL+ppLcchptpt.stpsss	.............h.hhpplp+clphEhpl+pGAENhhchh......ss-++t......................htpsptplpcSpp+..lphL+tpLpc.hptph...p...t...................	0	142	264	477
+488	PF00570	HRDC		HRDC domain	Bateman A	anon	Medline:98060076	Domain	The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.84	0.72	-4.26	147	6087	2012-10-03 03:05:55	2003-04-07 12:59:11	18	73	3520	22	1677	4778	961	67.30	27	11.64	CHANGED	phslhcpLpphRcphA.ccp..s.lsshhlhs-psLhplApt.hPpshpcLtpl...pGluptplc.caGpp..hlphl	......................tlhptLtphRcph.A.ccp.......s..lsshh.....lhsDpsLhphA..c......t..h....Pp....o....hs-lhpl....pGlu.tp.+lc..+aGpt..hltll................................	0	541	1053	1412
+489	PF03878	YIF1	Hrf1; 	YIF1	Wood V, Bateman A	anon	Wood V	Family	YIF1 (Yip1 interacting factor) is an integral membrane protein that is required for membrane fusion of ER derived vesicles [1]. It also plays a role in the biogenesis of ER derived COPII transport vesicles [2].	25.00	25.00	27.70	27.00	21.90	24.90	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.54	0.70	-5.22	6	451	2012-10-01 22:34:14	2003-04-07 12:59:11	10	7	302	0	283	437	3	221.80	34	73.12	CHANGED	hltsshss.huhtYGpslsspGpEhVcpshs+aluss+L+YYFsVsssYVspKLtLllFPahHps...............Wphphc.......p-s.lPPR.DlNAPDLYIPhMAFlTYlLlAGhtLGlQc+FoPEhLGlpASoALAalhlEllhlpLuLYLlslp..oshsslDLLAasGYKaVGlILusLssllah...uYYllhsassluhuhFllRoL+hslL...usssstshsshs...........tppp++hYhLhhlAAsQ.llhaWLo	......................................h...t.h...huhtaG.pshhspup-hhpppl.s..+al..s.s.....s.....t..L+aYFsVsstYVhpKLtL.llFPa.hHc.s.................................................Wphphp..........................ptt.hsP.R.D..lN.......u........P....DLYIP...................hMuhlTYlLluu....hhhGh.......p.......s............p....Fs.P.EhLuhtsopuls...hhhh.EllhlpluhYll.s..lp......ssh.shlD..LlA.asGYKaV...u.h.lls.l.ls.s.h.l......h......s.....t......hsa.....a.....h..s.hhashhuhshFl.........l.........RoL+hhll..........s.sss.t.t......t....................ttpph+hhhlhhhu.hh.Q.hhhhWL..........................................................................	0	99	159	232
+490	PF02793	HRM		Hormone receptor domain	Bateman A	anon	Bateman A	Family	This extracellular domain contains four conserved cysteines that probably for disulphide bridges.  The domain is found in a variety of hormone receptors. It may be a ligand binding domain. 	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.80	0.72	-3.96	131	2035	2009-01-15 18:05:59	2003-04-07 12:59:11	17	119	140	37	924	1697	0	64.90	28	8.33	CHANGED	s.hCstsaDsh.hCWPpsssGphsshsCPphh...t.pt.........................pu.....pspRpCsts....GtWsph...........sshspCtt.	.............................t..hCstpaD.th..hCWP.potsGph.s.thsCPp.hh.......t.......................................................pG......pshRpC.sts......G....Wsth...........s.sshspCt.....................................................................	0	149	213	503
+492	PF01381	HTH_3		Helix-turn-helix	Bateman A	anon	SCOP	Domain	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.58	0.72	-4.12	175	36941	2012-10-04 14:01:11	2003-04-07 12:59:11	17	294	5111	176	7651	48830	5885	53.20	22	32.31	CHANGED	l+phRp..ptshop..pplActhG..lspstlsphEpG....pppsshptlhpluchls.lshshl	.............................lpthRp....pp..s..l.oQ........pcL..A.c.t.hG............lo.p..s.s....l....u....p..h....E......pG........pp...p.P...s....h....p..h....l...h...p.l...uphhs.hsht....................................	0	2481	4888	6400
+493	PF01402	RHH_1		Ribbon-helix-helix protein, copG family	Bateman A	anon	Bateman A	Domain	The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement [2]. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.46	0.73	-7.61	0.73	-3.86	49	5913	2012-10-02 18:44:02	2003-04-07 12:59:11	16	35	2497	74	1378	3973	439	38.40	24	37.71	CHANGED	plolplscchhcpLcchuccts.hS+Sphl+tAlpphhpp	.............lslplsp-hhcpLcphu.......p..p...p...s..ho+.S.cll+chlpphl.............	1	404	897	1169
+494	PF02954	HTH_8		Bacterial regulatory protein, Fis family	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.63	0.72	-4.41	86	19848	2012-10-04 14:01:11	2003-04-07 12:59:11	14	176	2830	54	5558	15626	3713	41.30	31	9.21	CHANGED	tlcc..lEcphltpALcpsssshscAAch.LGloRpoLth+l+ch	........................tp.hE+phIppsL..p...p...sp...G...s......h...s...c....A....Ach.LGl.s...RsTLhcKlcch................	0	1884	3516	4654
+495	PF04005	Hus1		Hus1-like protein	Wood V, Bateman A	anon	Pfam-B_12502 (release 7.3)	Family	Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo [1]. Hus1-Rad1-Rad9 complex may form a PCNA-like ring structure, and could function as a sliding clamp during checkpoint control. 	20.60	20.60	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.81	0.70	-5.47	34	342	2012-10-02 11:47:48	2003-04-07 12:59:11	7	8	284	3	231	353	3	286.70	24	90.95	CHANGED	M+F+splss...hpphpcllsslupluKhChl+LsssplhFll.t........sssGsQlWsplphss...lF-..pYp.lpSs.sp..spIsLEl.slssLhRAL+oups..............us..s.........................lpl+Ls++............tphPhLslphpssoh.........................................................tppslsp..-lPVclL.sppphpplpEPph.-sDlp...IhLP.sLhpL+sll-+h+pl................................ushlplpAs...........hpGpLp..........................Lslpo-.hlsloopa.psLtsstht.t..............................t.t.tttssspt.sptthsplpVDhKchsphLp.stplssspslhslsccpslhlhhhh.......pcsslpaalPuhs	..........................................M+F+s.l.s.........hphhpphhsslspL....t......K..h.s........h......l+lsspplphhht...............sssusplWs..pl.t..h.pt...............lFp..pap.hp..us..st...................NpIhlEl.shpsLtRAL+oups.......................................up......s...........................................hpl+Ls++..........................tphP.h.Lslshp.h.sh..................................................................tp.pphlsp...-lPVcll..p...pth...p.plp......p.Ph..s.s..p........s...-lp.....l.h.LP....s........Lt........p........l+..sll-+hcpl.........................................us.hl........lpAs...............hpG..pLp........................................Ltl.po-....h....hplsoha.ps.Lts....h........................................................................t..ttt....p..p.....t.tthspl..plch+ch.phLt....stph.p....spslhs....................lhppp...hhhh..hhh..................pss.lphhls...s....................................................................................................................................	0	77	128	192
+496	PF03810	IBN_N	IBN_NT; 	Importin-beta N-terminal domain	Griffiths-Jones SR	anon	PROSITE	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.70	0.72	-4.06	52	2930	2012-10-11 20:00:58	2003-04-07 12:59:11	14	77	330	59	2037	2826	22	72.40	20	7.63	CHANGED	AEptLpphppp..Psah.tlhpll.p..ps.s.psR...hhAulhL+shlpp+..Wp..................plstpp+ptI+spllphlhp	..........................................ApptLp.phpp....p...s......s..hh..hLh......pl..........l............s.......p.............s................s......................t..........s.R.............hh...A...ul.hL+sh..l....p..pp....Wp...................................t.lsppp+t.tI+ptllphlh.p.........................................................	1	655	1084	1648
+497	PF01485	IBR		IBR domain	Bateman A, Mistry J	anon	[1]	Family	The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (Pfam:PF00097).  This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain [2].  Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms.  RBR family members play roles in protein quality control and can indirectly regulate transcription [3].  Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes.  The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease [3][4].	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.68	0.72	-4.10	166	4521	2012-10-06 20:19:25	2003-04-07 12:59:11	16	133	321	4	3180	4384	29	66.80	23	18.68	CHANGED	p+...a.ph...................tppph.........p..aCPs.ssCpthlthpptspp..................................................hpCs......Ct.tpaChpCppth....Ht..........sh..sC	..............................................................................................t.ph...........................+....hC.Pp........Cp.tsl..pt..s.s.sssp..............................................................................................................hpCs..t...........Ct..tpF.Ca..h..Ct..t.t.h......Ht.....................................................	0	984	1588	2459
+498	PF01614	IclR		Bacterial transcriptional regulator	Bashton M, Bateman A	anon	Pfam-B_755 (release 4.1)	Family	This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that may bind to the regulatory substrate (unpublished observation, Bateman A.).	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.35	0.71	-4.45	23	10733	2012-10-02 14:34:25	2003-04-07 12:59:11	13	33	2457	47	2964	8004	908	124.00	23	46.91	CHANGED	tphpss.tlGp+lPlauouhGKsLLAah.sccthpphlcp..hphpphTptTlos.psLhcpLsplRpp.GauhssEEpptGltulAAPlast...puplluAlSlossssRhscpphpp...hhshlppsApplopp	.............................................................................h....h..tlGp+.hP.h..a.s.o.uhG+slL...Ahh...sp....p.p...h.p.p.h...l.pp..............t.h...p....t...h......o.......t....p..........o.....l...s......s...............t.......t...L....h.....p.......p......L....t......p.......lR.......c....p......Ga.u......h...........s...........p..........p......E..h..p............G.....l.p.....slAs....P.l...h..st..........pG.p...sl...u...Al......olu............u....s...s..t...R..h...sp..p..p.hpp..........hhs.hlhpsAppls..t......................................................	0	689	1722	2433
+499	PF04760	IF2_N		Translation initiation factor IF-2, N-terminal region	Kerrison ND, Laursen BS, Studholme DJ	anon	DOMO:DM04974;	Family	This conserved feature at the N-terminus of bacterial translation initiation factor IF2 has recently had its structure solved.  It shows structural similarity to the tRNA anticodon Stem Contact Fold domains of the methionyl-tRNA and glutaminyl-tRNA synthetases, and a similar fold is also found in the B5 domain of the phenylalanine-tRNA synthetase.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.33	0.72	-4.31	141	7695	2012-10-04 14:01:11	2003-04-07 12:59:11	10	48	4486	1	1683	5556	2986	52.00	26	10.04	CHANGED	.splpVp-LAccls.....h.ssp-llcpL.p.h....Glt..tshsssl-p-psphltpphshp	.........pplsVtELAcchs.......h.pss-llcpLhp.h........Ghh...sohsps.l-p-.s.hphlspchsh...........................	0	547	1098	1438
+500	PF05198	IF3_N		Translation initiation factor IF-3, N-terminal domain	Bateman A, Finn RD	anon	Pfam-B_629 (release 2.1)	Domain	\N	21.30	21.30	21.40	21.30	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.11	0.72	-4.05	181	4308	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	4162	1	1055	2633	2165	67.60	52	37.87	CHANGED	ppp...plN-cI+.s..pcVRLl.spcGcplG..................llshp-ALc.hAc-tsLDLVclu.........PsAcPPVCKIMDYGKa+Y-ppK....Kp+Eu+	......................hNpt.Ip.......plRll....s..p.Gcp.lG..................................lhshp-ALp.hAcct.sLDLVclu...........Ps..Ac.P.PVC+IM...D...YGKF..+YEppK....Kp+Et+.......................	1	369	701	898
+501	PF05004	IFRD		Interferon-related developmental regulator (IFRD)	Moxon SJ	anon	Pfam-B_4730 (release 7.6)	Family	Interferon-related developmental regulator (IFRD1) is the human homologue of the rat early response protein PC4 and its murine homologue TIS7 [1].  The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis [2].	25.00	25.00	25.20	25.60	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.98	0.70	-5.34	7	396	2012-10-11 20:00:58	2003-04-07 12:59:11	8	7	219	0	250	334	1	275.60	27	66.11	CHANGED	SD--us.pohS....s.s..ssuu.s-.hss.ht-thtppclE-pLcptlDtsp-KS...ApsR.psLctlphhl.s+hh.-Fl.-chhTLh-hlp+sh+KG+u.cEphLusplhuLlslQhGsG.cs-Elhcphts.LpsllpDu.otuhpsRtpCsoslulhsalussDspplht..tshc.lFthsa.h+sssss.Vlsst...slhusuL.AWuLLL......Tlsss.ph..phhppphstLsp......LLpusslslRlAAGEslAllaEhup............sh-p-.........F..hh-...shEpL..........sphLRpLAoDS.sKh+AK+D++tQRssFRDVlchlE	.............................................................................................s.......t......t.p...............t...h...ptst...p...pph.p........t...Lpthl-th..h-Kp......sp.sRpsuLpulhph....ht.s+..h.h..........-...hl...c...+hhT.Lhcsht+sl..........K+.Gp......u...c.....E........p..t.h.A.hthhsllslph.s.s.....p.................sc.clhc..p........hts.hL.................pp..hlp.Ds....sss.hp.....s...........ss..hp..sLulssal..us.s..-...p-h....pshc.ha.h.h..hp..tss.p.........h..sst....tsslhsuA.lpuW.ulLl.........................Thh......s.s....plp....p......h....h........cpt........h....t.t..Lss..........lL.p.u.s..-hs....lRlAAGEsl.....ALl..aEhup..........................................s.pp-........................................h..hh.p......shptL....................................hphlppLAs....-......u..sKtt.uKpD++p.Q.RusFRsllphlE......................................................	0	64	125	193
+502	PF00817	IMS		impB/mucB/samB family	Bateman A	anon	Pfam-B_1349 (release 2.1)	Family	These proteins are involved in UV protection (Swiss).	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.70	0.71	-4.41	113	9024	2009-01-15 18:05:59	2003-04-07 12:59:11	15	52	4250	224	2364	7309	2792	150.20	30	34.04	CHANGED	lDhDsFaAosE...thhp.......P..pL..cscPlsVssttt.................................................uhlhsssYtARp.hGl+su.MslhpAtc..l...............C...P.p.l..........lll..................................ssshshYpchSpplh.pllpch.s............lchhS.lDEsal........Dlos..h.phhss...............................................................................................................pplupplccplhcph.t..lssSlGlusschlAKlAoc	...............................................................................................lDhcsFaAulE..........hhpp............P......pL...pspPl..sVuus.t.p...........................................................................................tGllh.sss.h........p.A.+.p..hGl.+.su.hs.h.h.p...Ahc...h....................................s........P...p..l..................................hhl............................................................................................................................sss.h.phYtc..hS.p.plh.plh..pc.a..o......sh........................lEs.h.S..l....DE.ual..............DlTs........shp..hh.s.s.....................................................................................................................................................................................................................................................................tp.l.u.ppl+ppl.h..p.c.h..t.....lssos..G.l.u.s..s..KhLAKlAs...................................................................................................................................................................................	0	760	1436	1969
+503	PF04836	IFRD_C		Interferon-related protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4453 (release 7.6)	Family	Family of proteins thought to be involved in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF [1].	20.30	20.30	21.30	20.30	19.20	20.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.71	0.72	-3.79	13	196	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	99	0	108	166	1	54.50	53	13.18	CHANGED	NEhLR-lF-LGPslh...sssh+shKlo+hE+HhhNuAAFKARTpsRuKhRDKRusV	........NEhLR-lFpLGPslh...sssshKshKlSRhE+HLaN......uAAFKARTKuRuKsRDKRuDl....	1	24	40	71
+504	PF04762	IKI3		IKI3 family	Wood V, Bateman A	anon	Wood V	Family	Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation [1]. This region contains WD40 like repeats.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	928	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.64	0.70	-13.77	0.70	-6.74	34	404	2012-10-05 17:30:42	2003-04-07 12:59:11	7	9	257	0	291	526	10	666.90	27	69.81	CHANGED	MRNLpslspsphp.tsps.........hslhso..saDsso-slhhshu...ssps.sslElpphtpss........th.thlssa....................sclluhpahsD.......spplshshssGDllhsp.t.............ssspshlEIVGol-sGIpAusWSPDEEllAlsTtp.............psllhM.o+pFEslsEhsLs..s-Dlph..SpaVoVGWGKKETQF+G+t..uKA..................................h+DPThs.pl-pGtlot.Ds.tpssISWRGDGpYFAVool..css...........RRslRVasRE.Gp.L-SsSE.sVDGL...........EpsLuW+PpGsLIAusQ..R.pscp............h-lVFFERNGLRHGEFsL+h..st-Etl.....................hpLpWNuDSslLAl..hh.........p-c.............lQLWThsNYHWYLKQEl.h..t...t.............hpWcsE..+shplhssss..spl.hh-asapsspussh.stD.Gh......ssVIDGpplhlTPhphusVPPPMuhtclphs..........sslh-lAhutsspp............hAslspcs.lhhht..shpth..............................stpPhltsphsh.........t.tst.tph+plsalscs....plhllhsss.........................hsclhlhph.t-spp............hhhpphsphppllhhhspsshpt....hhhpsh.sGplh...........plssptphp.h.............phPphs.phclsthpsst................hhhhGL.ossG+LaAssphlu........sssTShhl..........T.................................psaLL.................aTTspch......................................LpFlcLs..............phpthtls.ssst.......DER....sRpIERGS+LVslhPoc.huVVLQhPRGNLETIaPRhhVLuslRph..lc....pccY+cAFhsCRopRlDlNIlaD.asP-hFhpNlth....FlcQlpclsalsLFlS..sLp-EDVTp..ThY+-sh...................................hp..ttttthhtsspsoKVNplC-AlLpsL........sphhspalpsIlTuasppsPPsLcsuLplltpLpt.......................sstps-pAlcalsFLsDVNpLYcsALGlYDlcLsLhVAQpSQ+...DP+EYLPFLppLpphsphc.R+FpIDcaLp+apKALpaLtphs	....................................................................................................................................................................................................h...........................................................................................lhsh..h.t..........hhhh.ttGplhhh................................tt..h-hhs..htsGl.shtWSsDt-hlhhhTt.t....................tpllhh.s.pta-sl.....-..ht...pt.t..........tt.lshsa...Gpp.pTQFpGp..hp.............................................................ttspl.oWR.GD..utahul.s...h....s...................................................hRhh+la..s.....R......-.....h.........L...pss.....u...E...h.....ssh..........................................t....sl..sW+Pp..G..s..hIAshp...p..h.pp...............plsFaE.+.N.GL.h.Hup.Fs..l.............tp...h......................t.l.Ws..ssSplLAl...h.............tsh...........................................lplWs.h..t.NY.Ha....YLKppl...h.................................hhWc......pshphhhh.....st...............................th............hphhathst..u.....................p.u......................shVlDG...pplhlTs....hp.s.............lPPPhs.hph.h................t.s.h..tlsh..p.........................hshh.tpt.l.hh..............................................................................h............................h..hhh.ttp.....hhhh....t................................h.....................................................t.....h..s....t............hhhp.........tuphh.................................t.........................t..s...h...hth.h.httt......................hhhul.s.ppttha.h.....s..t............ls....................pshoSh.h..........h............................................tall.....hTs.....p.p.................................................................h.hh.lt................................h........t.........................t....................hRt.lERGuhllsshspp.htllLQhsRGNLEslh.RhhVLs.lt.p...lt....th.....atpAh.hhRp.+lshsllh..D.a.tsp...Fht.p..ht......Flpp........l........tp.......p..hls.Fhs...................pL.........pppshst..shY...h...............................................................tpKlshlCpthht.hh.........................tp.h.sllTsasppt.s..t.lp.sLthltpht..........................................................t...t-pu...lpal.hhL..-sptlap.uLuhY-hpLshhlAppuQh.............DP+EYLPaLpp...Lpt...................................h.p.....pa.ID.hLtpatpAltpL.t..............................................................................................................................................	0	106	165	244
+505	PF00478	IMPDH		IMP dehydrogenase / GMP reductase domain	Finn RD, Bateman A	anon	Prosite	Domain	This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel  structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a member of the common phosphate binding site TIM barrel family.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null --hand HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.10	0.70	-5.56	84	7826	2012-10-03 05:58:16	2003-04-07 12:59:11	20	15	4695	86	1800	6840	6242	406.30	38	94.26	CHANGED	cuLTF-DVLLlPstotlh.scsclshp.....lo....+plpLslPllS.AsMDTVTEt.cMAIuhAptGGlGl.IH+.Nhohc.pQsptVccVK+.h-sshlpsshhhtPptpltps.thhtphthsuhslspttt.hhhlht....h.................................h.ppphlss..shshtps.phh.pp+htcl.lVscpspLhullohpDh.+sppaPpAs+....DppspLhluAAlGststshcRhpt..Lsc..A..Gl..DslllDoAHGaSpthlchl+tlKppaP..plplIAGNVsTs-uscs.LIpAG.ADulKVGlGPGSICTTRhVsGVGhP..QlTAlhcsAcsAcph......G....lPlIADGGIchsGDIsKAlAuGAssVMlGShhAGTpEuPGEhhh.hsG+paKpYRGMGSlsAMpc............GSscRYhpts......tpchVspGlpGtVPaKGslpchlhplhuGL+.uuhsYsGupslp-L+cps.......alRlosAth.EupsH	............................................................................................................................................................................................................................................................................p.uLTF-DVLLlPu.c.......Sphlssps-lsop..........................ls....cs..l.pls.l...P.l.l.o.As.MD......T.V.T....-s..chA...IAhAp..p.G.GlGl.....l......H......+...s......h......o...h...p......pQ.A...p....p....V..ccVKc..csshh.ss.hh..p..h.th..h.tt.thsshsl.tt.....hh....................................................................hhh..s.t.......h.t.ch.ph..hstt..h.shlhhpch.p..phPp.us+.....D.p.pu.+..L..h..V...u..A...A..l.G..s.........s...s........s.....s.........h...-..R....s....c..t.........L.l.c....A....G.....l........D....h.....l.....l.............l............D...........o.....A.......H...........G...H...........S.......p..t...........V.......l.......p.........h...........l.....p.......c......l...+..p...p..a..P...........p......l.p...l...I...A.GN...Vu...Ts.-u.scs....L...h.c.A.............G..A.Du......V.K.V.G.I.G...P....G....S....I.C.T..T..R......l...........l......s.G..........V.....G.s.P....Ql.o.A...lh.-.s...A....p....A.....A..+.t..h...............s........h.PlI..ADGGI+huGD.l..uKA..l...A..u.GAs....s.V.MlG..S....h....h.....AGs.-Eo.P.G.....-h..hh....h...................pG.........+.p...a.....K...p.......Y.hGMGShsA.Mpp................................GutsRYFpts........................tpKh..VsEGlcu.p....Vs.a....+Gslpshl..hp..hhGGLR.S.uhuYsGutslp-Lppps........pFlclss.uthtEut.........................................................................................................	0	567	1087	1490
+506	PF03941	INCENP_ARK-bind		Inner centromere protein, ARK binding region	Wood V, Griffiths-Jones SR	anon	Pfam-B_67765 (release 7.2)	Family	This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of  chromosome segregation with cell division in yeast.	20.60	20.60	20.60	21.00	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.75	0.72	-4.12	20	272	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	207	13	206	269	2	57.30	33	6.18	CHANGED	-IsSDs-s--sst.....hslsuWAcuspL.cptlhcQtth...DssplFGsIsPLclEEIFps	..........................-ltSDsps-D-sp.............p.p..slP..sWAc..uspL.pptlhpQtth.....-spplF.G.s...l.....s..hphE-lFt......................	0	68	112	169
+507	PF04179	Init_tRNA_PT		Initiator tRNA phosphoribosyl transferase 	Wood V, Finn RD	anon	Pfam-B_16986 (release 7.3);	Family	This enzyme (EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the  modification donor. As the initiator tRNA participates both in the  initiation and elongation of translation, the 2'-O-ribosyl phosphate  modification discriminates the initiator tRNAs from the elongator  tRNAs [1].	30.00	30.00	41.80	33.60	28.10	28.90	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.82	0.70	-5.62	20	202	2012-10-02 20:12:17	2003-04-07 12:59:11	7	6	165	0	148	203	4	381.70	35	89.56	CHANGED	pL++ssLSlpNRLpSIhpDupFVcc.Vssta.pLPLVANERCGtWYlsPchcusSuYFKSTDGHTuQWsFShRRLNLHLLsllscpsGhlIVDSTRRGKhMPDALSKTlPIWCAVlNpsla.spsp.............................phLhhPPphVusSEcspItp+.lstFVppLppL.tlDlppLpppl......pKPlRPhWh...............sscshhpssh.p.ptpsahsllLCTuS++sp..............suphpc.......sG..YlQGAuDDcEtWAp......GLTPslFW........sspppL..lsp.........uE--LsshlspLlppppppssspsst...lts............................ssslhlGthss...................tspashVlshssp.h.t.......psppppsppLphshtuuKhGS+pLRptLsplpsFlptphus................spplllsC-oG..+DlSsGlhLsllChaaspchp.........................hpt.......t.splsKphl+ppLshlhp.h...plNPSRuTLpSVNuaLM	........................................l++psholhNRLpSI.tDutFlpp.lttha...t.................h......PLluN.RCG.WYhsPpt..h..t..s.o....sYFKSTDGHhspWsFShRRLNlpll.h......h....tpps.Gh.....llVDSTR+.G.KthPDALSKTlPIWssVlNpsl.h.pt...t......................................................p.lhh..Ps.hlstoEcspIpp+.lstastplp.......ph...ths...h.tpLtttl......tKPlRPhWh.....................tsps..h....s...p........t.....tt....sahsllhsoASp..psp...............ss.t...pc.........hu..YlQGAuDDpE.Wuh......GLoPslFW........tptp.L..hss.........scppl.sp.hl..tplltpppttts.ttt......lt..............................................................sppl..lsthts....................................t......hs.h.ll.hstp......................s....pt.thlph.h..s.ssKhupp.....t.Lcp.Lsph.thhtt.htt.................................t.tlllh..C....p..sG..p.Dh..SlushLsllshh...as.p.ph..........................h.t........t...h.s....K....l..+p+Lshlhp.h....pspPSRssLppVpsaL...................................................................................................................................................	0	49	89	127
+508	PF02022	Integrase_Zn		Integrase Zinc binding domain	Bateman A	anon	PSI-BLAST 1wjb	Domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  This domain is the amino-terminal domain zinc binding domain. The central domain is the catalytic domain Pfam:PF00665. The carboxyl terminal domain is a  DNA binding domain Pfam:PF00552.	21.00	21.00	21.50	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.85	0.72	-4.51	92	14892	2009-01-15 18:05:59	2003-04-07 12:59:11	14	72	180	53	30	13552	0	39.60	77	6.93	CHANGED	ApE-Hc+aHsNh+sLppcFslPthVA+cIVppCspCphpG	........AQEEHEKYHSNWRAMASDFNLPPlVAKEIVASCDKCQLKG.....	0	10	11	12
+509	PF00520	Ion_trans	ion_trans; 	Ion transport protein	Finn RD	anon	Pfam-B_33 (release 1.0)	Family	This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is  repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.53	0.71	-5.07	285	20399	2012-10-03 11:11:44	2003-04-07 12:59:11	26	434	1652	37	9781	20841	2116	196.60	17	31.06	CHANGED	hhshlhsslFshEhll+hhuhsh......................hpYhpssaNhhDhlsllsshlshhht.ht.........................................................hthlchhRhh...R...hl+lhphhps....lptl.....ltslh.pshtslhplhllhhhhhhlaulhuhplatstht.t.................................................................................................................ptpssFcshstuhhhlapshTstuasslhhsh.............................shhshlahhhhhhlsshhllNlhlull	..........................................................................................................................................................................................hphhhhhhFs.h.Eh..h..l.....+.h..hshs..................................................................................ht.ah...p...s.....h....a.s....h..h....D...h..l....h...l...h...h...s....h.l..s.h..h.h.t.ht.............................................................................................................hp.hl.R.h.h.R.hh....R...............hl.....+..l....h..p..h...h....p...t.........................h..p..hl.................l......s..l..h....p......s...............h.......t...s.........l...h.....p.....l..h........l..l.........h....h...h....h...h.h........l...a........u....l..h..u..h...t....l....a...t...t...p...h....t.................................................................................................................................................................................................................................t..t..t....p.F...s...s...h......h....t..uh...........h.h...l.........h.........p.............h...............h.T..s...t....u....a.s..s..l.h..t.............................................................................s.h.h.s.h...l..ah....hsh....hh..l..s.s...h....h..hl.sl.hlul..........................................................................................................................................................................	2	2792	3895	6681
+510	PF03770	IPK		Inositol polyphosphate kinase 	Finn RD	anon	Pfam-B_1382 (release 7.0)	Family	ArgRIII has has been demonstrated to be an inositol polyphosphate kinase [1]. 	22.20	22.20	23.50	22.30	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.31	0.71	-4.67	109	1104	2009-01-15 18:05:59	2003-04-07 12:59:11	11	19	318	15	725	1054	13	210.70	27	40.30	CHANGED	allLEsLstsappP...CVhDlKhGsRpas.-....As................................pKtpp.pp+sppoTStpLGhRlsGhpla.p......................................ppst..hh.....phsKhaGR.slstp.phpculppFltss............thppttthht.....thlp+Lpplpshlcppct....aRhYuSSLLhlYDuc...................................................................................................................................................................t..spscl+hIDFA+.ssh................hsssshDcGaLhGLcsLlphhp	.....................................................................................................................................alhLEsls..t..t.......ap..pP...ClhDlKhGsRpasp-...ss.................................................................................................................................pKhpp..t.+pptooossLGhRlsGhpl...ht................................................................................................tpst.....h.......hhs.K........a.G+..s....h.s.hp..ph.p.p.s.lpp.Fht...................................tp.l..ht.........................hlp+Lpplpp...hlcppp....................achhuSSLL..hlYDup..................................................................................................................................................................................................................................................................................................................................................................................................................................................ttsplphIDFA+sh...................................................h.tts.Dc...GalhGLcsLlplh.................................................................................................................................................................................................................................................................................................................................................	0	250	366	558
+511	PF00612	IQ		IQ calmodulin-binding motif	Ponting C, Schultz J, Bork P	anon	SMART	Motif	Calmodulin-binding motif.	20.30	11.10	20.30	11.10	20.20	11.00	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.00	0.74	-6.85	0.74	-3.79	345	16654	2009-01-15 18:05:59	2003-04-07 12:59:11	22	705	467	44	8271	15224	358	20.70	32	5.40	CHANGED	ppuslhlQshhRuahsR+pap	.........pAAlhIQuhaRGahsR+ph...........	0	2330	3800	5778
+512	PF01007	IRK		Inward rectifier potassium channel	Finn RD, Bateman A	anon	Pfam-B_18 (release 3.0)	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.12	0.70	-5.65	13	1452	2012-10-03 11:11:44	2003-04-07 12:59:11	15	11	294	52	764	1256	32	284.90	37	78.63	CHANGED	VpKsGpCNVpasNlptc.ptRYLsDlFTTlVDlKWRapLllFshuFlsSWLhFGhlaWLIAahHGDLpt..................ssstTP......CVtsVpuFsuAFLFSlETQTTIGYGaRslTEECPlAIhlllhQuIlGsIIsuFMlGshhAKhApPKKRAETLhFScpAVIuhRDGKLCLMaRVGsLRKSHlVpAplRupLl+s+pTpEGEhlPLcQhDlsVshDsGs.DplFLVoPlTIsH.IDcsSPLa-luppsL.pppDFEIVVILEGhVEoTuhTsQARoSYlscEILWGHRFpPVloh..EcGhYcVDYSpFcpThEVs....TPtCSA+-LsEpK......Lhpshp..........sh-sph	......................................................................................................htKsGpsNl..h.t..p...h...t...p...................h.a..ltDl..aTThlD...h.p.W.R.a.hh.lFshsahho..W.hh.Fu...hh....aahlA...hh+G..D....l......................................s..h..ps.......C.l...p.l...p..u...FsuAFLFSlETpsTIGY.Gh....R...h.lT.-.cCP.ulhll.l.h..QsllGh.llsuFh............h..GshhsKhupP+...+..RA.p..Tlh.....FScpAV...............I...u...hR......c........G...+.L..CL....MhR..V..u..s......hR.......p..Sh..ll..p..upl..+s.p.L.l...+...s.p.......T.....E.G..E.....h..l....l.pQ.h-.l.s................l..sh.s.......t...u................c.....p..lFLl.P..l.....slh.H..ID.ppSP......lash.......s.t.p.....s.........l.....t.p.p..c..FE...........ll...............VhL-GhsE..uT....u.........h.o.s.QsRoSY.l........sp..E..IhW..............GaRF.s.ll....................c......p..s..hY..p...l.Dasp..Fp..psh.ps.......sP.......h...s.hh.............................t...............................................	1	170	277	492
+513	PF02174	IRS		PTB domain (IRS-1 type)	Bateman A, Mian N	anon	IPR002404	Domain	\N	21.00	21.00	21.10	21.10	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.14	0.72	-4.40	32	923	2009-01-15 18:05:59	2003-04-07 12:59:11	12	28	105	45	552	834	1	96.60	28	10.89	CHANGED	ptstF.V.lp..........hptsupcssl.pGsh.hLplopcsLhL............hpsppshlpWPhptLRRa........Gp.s..pshFoFEuGR+CsoGtG.asFpspc...upp..laphlppshps..pp	...................................t....a.V...............h.....s.....pt.sh..hG.s.h...hLplTp..c.......slhl.................sptpsc.psh..hpWsLpslRR..a.............Gt..s..sshFohEsG.Rp..sssG...Gh.a.thpssc......upp...I..aphltphhpt...t.........................	0	117	160	311
+514	PF02922	CBM_48	isoamylase_N; Isoamylase_N; 	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	Griffiths-Jones SR	anon	Structural domain	Domain	This domain is found in a range of enzymes that act on branched substrates - isoamylase, pullulanase and branching enzyme. This family also contains the beta subunit of 5' AMP activated kinase.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.28	0.72	-3.94	59	8560	2012-10-02 20:10:03	2003-04-07 12:59:11	13	125	3303	51	2144	6979	701	85.90	27	11.95	CHANGED	sLGuph...........sspFplWuPsAppVplhh.hss.....h.tpphshp.....tpsGlWplhls.......sht.......t.hYtaclpsss......................G.....hhhhhDPYA	...........................hGuphpst............GspFsl.WA...P.s...A.p.pV..pls...s.hss..................ht..t.p..p...hs.hp............tpssGlWc.h.hls...........slt.G......................t.hYpYclpsst.......................G..........hhhhhDPaA...............................................................................	0	684	1346	1804
+515	PF00857	Isochorismatase		Isochorismatase family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_566 (release 3.0)	Family	This family are hydrolase enzymes.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.87	0.71	-4.33	64	13319	2009-09-13 17:43:14	2003-04-07 12:59:11	15	81	4229	124	3488	9497	1254	172.10	20	81.06	CHANGED	sALl..ll..DhQ.pshh............tstphpphltshpcLlcsu..+pts.....hs....llhspphhp.................................hhh.ss.ssplhsplps......s-hhlp...Kp......phsuF.......hsosLpphLcp...psl..c...plllsGhtTphCV...tsTshsAhpp.Ga.....plhllsDu.....suuhs......spt.pptulppht......hh.uhlhsspp	.........................................................................................................................ALl.llDhQ..pshh...............................hsh..ss...t..sp..p....ll..s.s..l....s..pL...h.p..t..s......+.t.t.s..............hs...............llhspphtt............................................................................................................s....h...h..h......s..s.........s..t....p...........l..h.......s...........p...L.......ss.............schl..lp....................Ks................phuuF.......................................tsTs.Lp.p......h.L.+p........p.ul.....c...............pll..lsGltTchCV.................tpTs..h......s......A......h.......ph...Ga...............................pl.hllpD.A.....su.shs................tpt..pphul.t.tht...........thh.s......................................................	1	1002	1990	2805
+516	PF02373	JmjC	jmjC; 	JmjC domain, hydroxylase	Bateman A, Wood V, Mistry J	anon	[1]	Family	The JmjC domain belongs to the Cupin superfamily [3]. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification [4]. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation [5].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.21	0.71	-3.84	32	2778	2012-10-10 13:59:34	2003-04-07 12:59:11	17	174	310	95	1692	3393	72	108.20	25	10.42	CHANGED	hlYhG.hhophsaHhEspshhS...lNahchsus+hWaslPsppspphc...phhpcp.......h.tp.th.lpphsshhsPph..LhptslsshchsQcsGEhVhs.stsaHsshNhGashu.uhNF	..........................................................................hhhuh.hot..hs.h.Hh-.stt.hh.u.............ls..a....h............h.........h..........s....us......K.......t...W......a...hl.P.s.p...p..t...p...p..hc........chhpph..........................tp..h....lp.hh...hs...h..h....sph.........lhp.h...s..l......s......h.c.............h..hQps...G-hlhh.st..sh.H.t.......s..hNh.G.h.s.hs.uhNF.............................................................	0	478	771	1239
+517	PF02099	Josephin		Josephin	Mian N, Bateman A	anon	IPR002950	Family	\N	19.90	19.90	20.20	21.00	19.40	19.60	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.19	0.71	-4.60	10	651	2009-01-15 18:05:59	2003-04-07 12:59:11	12	14	168	8	262	634	1	135.20	47	52.38	CHANGED	+Q-us..LCAlHCLNsLLQ............................GsaFocs-LusIApcLDppEcsphsp.....sspsstoaht..csSpNhspsG.FSIpVLppALclWsLpllsa..psschpstph...cP-spsuFIhN..........hscHWFsIR+l.........supWaNLNSlLuA.PcaIucpYLusFLcplcupGaSlFlVps.s	........................+Qctp..LCA.HsLNNlLQ..............................................................................................u.p.hFo..pLspIsppL.s.pph.h..............................th....psp.tN.h...ss........G.aslp..........VI.......sALp.s.hu.hchl.a....s.c..h..phhtl................s...p.huFIhN.......................................hccHWhslRcl.........................................s.tpWaN...LsShLsu..P-..hI.u.-..s.h..L..t.hFL...s.p.l.p..p..p.G.h.plFlV..s...........................................	1	94	133	200
+518	PF02214	BTB_2	K_tetra;	BTB/POZ domain	Bateman A, Eberhardt R	anon	Pfam-B_27 (Release 5.2)	Domain	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.34	0.72	-3.78	46	3855	2012-10-02 01:20:04	2003-04-07 12:59:11	17	108	285	59	2405	3406	33	92.00	29	21.51	CHANGED	lhlNVGGh+FpTppsTLsph.PcohLuphhc....................hp.assspsEaFFDRsPptFcsILsaYRo...GcL+ts.phslptahcElpaatlsph...lcpC	............................................................lhlNVG.Gt.h.apTp.....h.p.T.L......sph...Pc.o..h.L.uph.hptp.....................................................ht.hc..s.p.ps..c.a.Fh..D..............R..c..st...h............FphILsa...hRs.............G.......cL.....h........h.....s.......t..p.....h.......s.....h.t....t.h........hcEhcaatlsth.........................................	0	702	944	1575
+519	PF02705	K_trans	K+_trans; 	K+ potassium transporter	Bashton M, Bateman A	anon	Pfam-B_677 (release 5.5)	Family	This is a family of K+ potassium transporters that are conserved across phyla, having both bacterial (KUP) Swiss:P30016 [3], yeast (HAK)  Swiss:P50505 [2], and plant (AtKT) Swiss:O22397 [1] sequences as members.	24.80	24.80	24.80	24.90	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	534	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.90	0.70	-6.15	84	2676	2012-10-03 01:44:59	2003-04-07 12:59:11	11	6	1808	0	887	2162	250	506.20	40	80.78	CHANGED	slsALGlVaGDIGTSPLYshpssh...............thshssstpsllGlLSLIhWoLhlllolKYlhllhRADNcGE.GGIhALhuLlp.................................................ptsptttal.......................hhhlullGuuhhhGDGlITPAISVLSAlEGLp...lhsPslp.......shllslolsILlsLFhlQphGTsplGphFGPlMllWFhsluslGlhs..lhpp.PtlLpAlNPhYAlpFlhp..psh......huahlLGuVhLslT.GuEALYADMGHFG+psIphuWhhhVhPuLlLNYhGQGAhllppP...tsh........pNPFa...thh.Pp....hhhhPhl.lLAThAslIASQAlIoGuFSlspQAlpLshhP+l+lhaTSppptGQIYlPhlNWlLhluslhlllsFpsSssLuuAYGlAVohoMllTTlLhhhhhthha.chshhhshhhsshFhhlDhsFhsANlh.KlhcGGWhPlllusllhslMhoWppG...pphlhpt.....................................htpptl.............slsphhptltp..ps.s...............................+lsGs.....AlFh...oss........pslP.slh+h.lcp.pslaccslhlolhph.shPpls.scRhplp.....pls.......ssha+lhlpaGFh-	............................................................................h.lsAlGVVYGDIGTSPLYsh+psh..................tsthshshspsslhGhlSLIFWsL..hll...solKYlhhlhR..AD.N.p...........G...........E..G..........GIhuLhuLst.................................................................................t.t.t..tptphh..........................hllhullGuuhhhG.....Dul....lTPAI.S..................VhSAlEGLc.......lssP..thp..................shl.ls.lol.l.lLshLFhlQ+aGTshVGph.Fu...P...lMllW...F...lhL...u..s...l...Glhs.....Ihtp....PpVLpA.l....NPh.aAlpFhhp....pst.....huah....s....L....G..uVh......L..........ulT.G...........uEALY..A..DhGHF.....G.....+....hsIp......l............A.Wh......h......lV...h.PsL...l.......L.NY....h....GQG..AhlLpps.....psh............pNP..FF..hhs..Ps..............hh.hhP.hl.llAs..l.A.s..l..IASQAlISGsFS..lspQAl.pLGh.lP+....h.+IhHT...Sc....pp.GQIYIPhlNWhL..hluslhl..llsFc...................s.....Ss.......pLuuAY...........G................lAVTsTMllTol.Lhs..hl...hhth......W..chshh.hs.hhhhlh.F..h.sl.-..h.saF.sAslh.K...lhpGGWlPlhluhlhhhlMhsWcpGpthhh..cp.............................................................................t..c..p..t.h...........sl..pthl.t.hpp....ps.s.....................................................RVsG.s.....uVah.....ops.........ss..lPhshhH..lpp.cslHc+slhlslhs..ssPhV...scR.hp.lc..........plu................tha+lhhpaGap-.....................................................................................................................	0	173	506	707
+520	PF01920	Prefoldin_2	KE2; 	Prefoldin subunit	Enright A, Ouzounis C, Bateman A, Finn RD	anon	Enright A	Family	This family includes prefoldin subunits that are not detected by Pfam:PF02996.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.18	0.72	-4.28	56	1643	2012-10-02 17:27:01	2003-04-07 12:59:11	15	22	498	7	1100	1563	97	102.30	18	68.87	CHANGED	QphlspapplppplppltpphpphctplpEhcpshcELphls--...ppla+hlGslhlcp.shpcspspLccct-tlptclcplcpphcplppchpchcpplpp.hhtst	.................................................t..tphpphppphptlt...pp.h.p..p...lcpph........p.c.t..c.....h......s..hc........EL...p.....l...s..s-................pp.la.chl....G.s.l.........hlcp.shp.cshpplppchctlpp.c....l.........c.plc.pphpphppphpc....hcppl.thht..t..............................	2	356	593	877
+521	PF01344	Kelch_1		Kelch motif	Bateman A	anon	[1]	Repeat	The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.	20.10	20.00	20.10	20.00	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.11	0.72	-4.41	207	19043	2012-10-05 17:30:42	2003-04-07 12:59:11	20	753	1386	88	10669	22556	644	46.00	27	22.72	CHANGED	tRsttussshssplYllGGhss..................tphhsslphacsp.....sspWpthssht	..........................Rtthusssl..s..s..p..l.Y..s.....l..G.Ghss.....................................tphh..ss..V...E.p...YDsp...............sspWp.hssh..............................................	0	3018	4230	6832
+522	PF00013	KH_1	KH-domain; KH; 	KH domain	Bateman A, Eddy SR, Finn RD	anon	Published_alignment	Domain	KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.88	0.72	-4.32	396	19558	2012-10-02 00:34:43	2003-04-07 12:59:11	24	384	4888	106	9071	18086	3141	61.70	24	16.12	CHANGED	thplhls.spt..hutlIG+sGp.sIcplpcpo.usp.Ipl.......pp....................p.hlpl.p..G.s..pslppAtp.......hl	.....................pl.ls..sph......hu..plI..G+..t......Gp..s.......I+p.....lpp...p...o..G....s....p...Ipl...............................spt........................................pt..h..lpl..s........G..s..pphptAtt...........................................................	0	2547	4378	6873
+523	PF00109	ketoacyl-synt		Beta-ketoacyl synthase, N-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Dotter	Domain	The structure of beta-ketoacyl synthase is similar to that of the  thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.  The N-terminal domain contains most of  the structures involved in dimer formation and also the active site  cysteine [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.80	0.70	-4.90	167	24208	2012-10-02 12:25:54	2003-04-07 12:59:11	21	1647	5964	191	6576	27004	6262	223.60	26	22.85	CHANGED	scslAlsGhusphPsGss.........s-phWchltpGpsuls.........phs......hsth......ssphsGpshs..t...........tFDsthFshss+ps.tMDPppRl.hLpsuhEAlEcAGl.sstph...psst...........sGVhhGssts...........sh.......tt..hhttts.......htshs..hsss......ssushuu+luat...hGhcGPuhsVsTACoSu.hsuh+hAhpslRpGcs-hAlAGGssshhsPtsh.ssasptt..hhusp...s.....s+Aasstu.........-GalhuEGhGslllpcht-A	................................................................................................................................................................lslhGh........uhh.s.h.u.s.............................ptha.p..lhtGt.s.slt.............................hs......................t.t.....h....................t...s...t......h................s.................u...............p............h..........s...........................................................th.......-.......s.............h....................t............h...........s........c................................t..h....D...s.t.....p.........ph...hl.t.s.u...h..c...A..........l.c.c................A...G.l...ss.pph.........................pssp.............sGVh.h.Gsshs..........sh....................................tt.h..hht.ttt..................hp.s.s.....hsst..........................hs.sh..h...u..u..c.l.u.hh..........hs.........l...c...G....P..s.....h...s...l.s.T....A....Co...S..S..hs...ulchA.h........p.....sl..................p...t.........G......c.....s............-........h......s..........l...u..G....G....s.p....h....h....h....s.....s.....h.......s..h.....h.....s.F.......s.....th......t....hh....ots........s..................................s+shcsts..................DG..a.sh...GE...G.sGhllLccLpcA............................................................................	1	1853	4027	5613
+524	PF02801	Ketoacyl-synt_C	ketoacyl-synt_C; 	Beta-ketoacyl synthase, C-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Dotter	Domain	The structure of beta-ketoacyl synthase is similar to that of the  thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.34	0.71	-4.26	165	23531	2012-10-02 12:25:54	2003-04-07 12:59:11	17	1627	5851	190	6174	21515	3921	108.60	35	10.85	CHANGED	hAhltGsAsspsG.tssuhssPsusuQ..tcs.....lcpALssAsls.Ps-l-hVEAHGTGT.lGDshEspAltssaGptt...........p..lhluSlKSslGHspuAAGssullKslLAlccuhlPPolphc	......................................................................hA.lhGhussp..DG.......h...p...........s........hs.....sPs.utut.......tps..........lcp..A...L....p..p.....A.....u........l....s....s.....p................p.............l.....s....a....l....p..........AHG.T......u.T.....hG...Ds..........hEspA.l.tp.s.a.Gptt...............................h..hl.u.S....s........Ko.h.GHh...u.AAGss....th.l.....tslh..u.l....c....c.s..hlPsolph..............................	0	1709	3766	5251
+525	PF00225	Kinesin	kinesin; 	Kinesin motor domain	Bateman A, Finn RD	anon	Prosite	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.08	0.70	-5.74	84	9740	2012-10-05 12:31:07	2003-04-07 12:59:11	18	241	436	149	6035	9371	509	290.90	32	34.34	CHANGED	RlRPhsspEpppsppthsph.........................................................tpttpshtssptpppsFsFDpVFss..sso........ptplapph.h.sllpssl.cGaNsolFAYG.QTGSGKTaTMtG.................................tp..GllPRslcplFpplpp.t..........................................................................................................taplp.lSalEIYNEplhDLLssp..............................ppp......Lpl+-.csp.t....shVpsLoph.Vpshp-lhpllphGppsRpsusTphNppSSRSHulaplplpppshstt.t.......................u+LsLVDLAGSERsscos.........stsp.h+EussIN+SL.sLGpVIsALsps................................psHlPYR-SKLTclLpDSLGG..su+ThMlsslSPusp......shpETlsTL+aAsRA+pl	......................................................................................................................................................................................................................................................................t....pta...t....F....D.t.l..a.s.......pss..................................Qpp.l.a.p...th........s.p.s.l....l.p...........s...s.h......p.......G.......a..N...............s...............s...l.FA.............Y.G...Q.......T..............G..................o............GK......T...a.T.M...Gs.......................................................................................pp.Gl.....l..s....p....s...........h.p...p.l.Fp...t...l...p.p...t...p...t..t....................................................................................................................................................................................................................................................p.a.plp..s...Sah.E...I.....Y......s.......E.....p.....l....h....D.L.....Lssp.......................................................................tt..........tlp.lc.-...c...s...p.....s..........hhl.t......s...l....p....p.....h..................l...p.............s......h..p..............-...hh..........p......l....h...............p.......h.....G.............p...p.....p...............R.......p...............s.............u........s...T....t...h....N..p....p................S.......S.........R.....S............Hu...l....hpl.p...lpppph..t..t..........................................................hhuclpL...V.DL.A......GS........E......Rh............t..........p.......ots...................................Gp.........p...........h.....................c.........E..............ut..........p.....I.N.p..............S.L...s.L...G....p.V..Ip..u...Lspt..............................................................................pt..a..l..P....Y.R..............sS........K....LT.............p......l...L...............p................-........S..L..............G................G.......s.............u.............+.....T.............h...........hl.ss..l......o........P.......st.........................shpET.l.sTL..c.aAp.Rs+p..............................................................................................................................................................................................................................................	0	2295	3451	4869
+526	PF00467	KOW	L24;Ribosomal_L24;	KOW motif	Bateman A, Finn RD	anon	Prosite	Family	This family has been extended to coincide with ref [1]. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.06	0.73	-7.32	0.73	-4.05	235	10200	2012-10-01 20:16:17	2003-04-07 12:59:11	24	51	5026	253	2995	5949	3093	34.10	32	20.34	CHANGED	hGchVhlhsGt.pG.ctGplhclpppp............p.Vhlc	.......G-pVpVlsG..t.......pG..pp.Gp.Vhcl..cc...............sp.Vhl........................................	0	1014	1819	2444
+527	PF01352	KRAB		KRAB box	Bateman A	anon	Bateman A	Family	The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-8.05	0.72	-4.51	69	10165	2009-01-15 18:05:59	2003-04-07 12:59:11	22	1426	46	1	4775	8709	1	40.40	54	7.64	CHANGED	VoFcDVAVsFopEEWphL-suQ+sLY+-VMLENapNLlSlG	..............lTF.cDVAVsF..opE.EWph..L-..su..Q....+sL..Y.R-.VM.L.EN.YpNLlSlG.............	0	382	388	643
+528	PF05178	Kri1	Krr1; 	KRI1-like family	Wood V, Bateman A	anon	Pfam-B_8372 (release 7.7)	Family	The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus [1].	25.20	25.20	25.40	25.40	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.66	0.72	-3.74	75	304	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	266	0	220	306	7	112.60	31	16.75	CHANGED	+cRKccE+cp........+cpElp+LKsLKhpElp-Klp+I+csuG.....tt..........................hsh...s-c-l.....-....s-FDspcaDppMpc.hFs.....-cYYsp...........................tc.cKPpa.--D.-l..t-hh......sstc..............c-	...................................+cRKcpEKpp...........+pcElc+LKsLKhcE.lp-K..LcKl+cssG......ps..............................hsl...s-c-l.........-....sDFDsscaDcpMpc.hFs..--.YYst.............................tctcKPpa..--D.-l..t-h.s.....t..........................................................................................	0	76	123	184
+529	PF02735	Ku	ku; 	Ku70/Ku80 beta-barrel domain	Bateman A	anon	Bateman A	Domain	The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 Swiss:P12956 and Ku80 Swiss:P13010 proteins that form a DNA binding heterodimer [1].	25.00	25.00	26.10	26.00	24.30	23.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.93	0.71	-4.91	29	1701	2009-01-15 18:05:59	2003-04-07 12:59:11	11	32	1062	4	808	1704	49	191.60	20	42.31	CHANGED	lplG.....tlslsVpl..ashspppthhhhhhhtcc.........p.spscpcplstpssp.............................tlp...ts-hh+ua......hhsschlslsc--lcplp.hss.......tslclluFhshs..lhchhahcsuhalhPccpts....tpsassLh..cshhcppphAls+ash+s...p.plssLhPpt....................................................puhhlhpLsas--lR.shshhthtsstt.......sppplchh	...................................................................................................................phu.....hlslsVph....asss.p.p.p.p.h.......h.h..hhtpp.........................hshhc..hp..ph...s.p.ps.sp................................................................................pVp...tc-.lsKuY......hhs.s.c.....h..Vh......lsc--l..p.p.lt..tss...............................pslclluFls..ts..t...........l......h.h.hh....c..c.s.h..a.l...h.Psp..p...ss..........................................................c.s.as..hLh..cultcps+.l........Als+h..sh+p.......+.p.lssLhPtt............................................................................pslhlhpL.as--lR...sh.s...h.h..t.......................h.....................................................................	0	264	480	665
+530	PF03730	Ku_C		Ku70/Ku80 C-terminal arm	Bateman A	anon	Bateman A	Family	The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C terminal arm. This alpha helical region embraces the beta-barrel domain Pfam:PF02735 of the opposite subunit [1].	21.20	21.20	21.60	21.40	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.21	0.72	-3.46	18	467	2009-09-10 20:09:42	2003-04-07 12:59:11	9	16	255	7	249	454	0	93.20	21	14.94	CHANGED	lc.saposphtNP.LQpaapsLpslALchpEsh.slDtplschpphpc..+hssh..lsch+phhh.s-h....p.-spsutcpppcs..Eus.....suKKsKh-h	..................................tapssph.NPsLQpaa.p.....sLpshAL.....c.....p.....t...P......ts.....D....slsc..hpphs.c....chssh.........lp.......ch.+ph..h.....pph........p.ctt.htt.cp..t..t...tp...t...........hp...........................................................	0	75	127	191
+531	PF03731	Ku_N		Ku70/Ku80 N-terminal alpha/beta domain	Bateman A	anon	Bateman A	Domain	The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the amino terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface.  The domain comprises a six stranded beta sheet of the Rossman fold [1].	20.60	20.60	20.70	21.00	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.24	0.70	-4.92	17	702	2012-10-10 16:07:06	2003-04-07 12:59:11	10	19	300	4	399	710	4	208.10	18	32.63	CHANGED	ullallDsu.sMhps.pspps.......hp.shpshpphhtp+lhsps+.DhlullhauT-pscN.....sssapNlhl.........lp.....clshsshcplpclpphhps............tsstpsshhsuLhsshsl...hpc..spt+hs+++lhlhTs.csPh.......stsphchhhtc.................upDhpppthphs..hhhL......stt...phhap-.hp.utcp.pthhhs.pt........phpchhpplpshpphcRth	........................................................hlhhlDsu.sM....hp..........sttp................h...p.sh.ps..ltph.hppplhss....s+...Dh..lul..lhas.T......c...........p.......o......c.............s.............................sts..........a.p.plh.l.......................................hp.......pls.s.s.hctlpclpph..hps...................................s.....s..p..p..s.s.....hh.ss.L....h.ss.h.p.h.......h.p.p.........t........t...t..p....h.tp++.l.hl.hTstcsPh..........spsphp.t.hhpc............................................st-lpp.s..h.thp..hh.l...................t..p.p.h.hp.....-........p.......s...t...........t..................................................................................................................................................................................................	1	128	216	324
+532	PF00014	Kunitz_BPTI		Kunitz/Bovine pancreatic trypsin inhibitor domain	Fenech M	anon	Prosite	Domain	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich  alpha+beta fold. BPTI (bovine pancreatic trypsin  inhibitor) is an extensively studied model structure. Certain family members are similar to the tick  anticoagulant peptide (TAP, Swiss:P17726). This is a  highly selective inhibitor of factor Xa in the blood  coagulation pathways [1]. TAP molecules are highly  dipolar [2], and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha  helix [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.26	0.72	-3.76	147	4915	2012-10-02 12:37:03	2003-04-07 12:59:11	18	353	273	213	2635	4772	22	53.40	35	18.48	CHANGED	hCphsh.ssG..s.Cp...u......th....+aaas....spsppCp.pFhYuGCtGN..t.....NsFpohc-CpphCt	...................................C.hsh...p....tG.....s...Cp.....s..................hh........Ra..a...as............s.ps...ppCp...pF..h.Y...u.................G.C...t....G...N...t.......NsFtopcp....CpptC................	1	878	1112	2046
+533	PF03521	Kv2channel	Kv21channel; 	Kv2 voltage-gated K+ channel	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	42.50	29.90	18.40	19.70	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.92	0.70	-4.93	4	108	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	39	0	63	94	0	204.20	45	32.14	CHANGED	KosEous+KDKspDNHLSPSRWKWs+RsLSETSSNKSF-sK.QtsspK.......spSSSSPQHLssQpLE-lYNchsKTQSpP.lNopp.sQsu+P...tEElEMpplssPps.LsssppEullDMRShSSIDSFhSCATDFsEopR.shoPhuu..hphphss..ss.cta.tupst.hLs.pttpusAs+-uhpEhtststshp.-sts...h..s..pus.hlESP+oSlKssNPL+.RSLKVNFh-ucsso..ssssshps.Plp.tsashtusttlsThhL.-p	.................Kss-s.spK-psp.DNHLSPs+WKW.s.++.shSETSSsKSa-sK.QtsspK.................sp.oSS.....S.......P.......QHLssQpLE.hYNchsKT.Qsps...Nscp.pt.t.t+P...cEElEM-plssP.t.Ls..s.psEsl.lDM+Sh..SSIDSFhSCATDFsEspR.shsP.su.................................s.pttt..ssp..sh.th.s..s.sh..ps..ss............s.h.-SP+SShKssNPLK.RuLKVNFh-s.c.ss...ss...hh.....s.....hs....s...........................................................................................................................	0	2	8	24
+535	PF02828	L27		L27 domain	SMART	anon	Alignment kindly provided by SMART	Family	The L27 domain is found in receptor targeting proteins Lin-2 and Lin-7.	20.20	20.20	20.40	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.41	0.72	-4.28	20	1179	2009-01-15 18:05:59	2003-04-07 12:59:11	11	37	100	20	527	978	0	53.10	24	14.32	CHANGED	slppsh-lL-cLps.ssss.....pchppLpplLpstahpullcla-pltppshssssss	........................hphsh-lLccLps..spst.....p-hptLpplLppsahp..u......L......l.csH-pltppphtss............	0	84	132	273
+536	PF02448	L71		L71 family	Bateman A	anon	Pfam-B_1976 (release 5.4)	Family	This family of insect proteins are each about 100 amino acids long and have 6 conserved cysteine residues. They all have a predicted signal peptide and are probably excreted. The function of the proteins is unknown [1].	25.00	25.00	32.90	29.30	18.80	18.20	hmmbuild  --amino -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.18	0.72	-4.14	10	105	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	12	0	35	105	0	71.40	36	65.23	CHANGED	p.CccltcpCpcshpRLssssD.slchFNcpCRccsc..hpWRsVoRCELp+lsClh...cspshsCcNlA........chssh	...CccltcpCppshpR...LssssD...slshhNppCRccst..hpWRsloRCELpphsChh...cscphsCpslAchh............	0	10	10	23
+537	PF00753	Lactamase_B	lactamase_B; 	Metallo-beta-lactamase superfamily	Ponting CP, Bateman A	anon	[1]	Domain	\N	22.70	21.90	22.70	21.90	22.60	21.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.20	0.71	-4.65	305	34807	2012-10-02 15:46:01	2003-04-07 12:59:11	22	191	5226	350	10222	34846	12115	193.00	14	50.57	CHANGED	hsthsssshllt........ss.spsl..llDsGhststtthh..............................hthpstplctll..lTHtHhDHhGuhttltpthshshhhttttttthhtthh.............................................................hhhttttththtththhhhts.stsssshhhhh.....ttppllhsGDhhh......stsththth...........................................................h.....................h.....hh..uH	...................................................................................h....ttsshllt...........ts..pph.l.....l..lDsGhshsthpth...........................................................hthp.s..t.p..l...p....t....l....l.......lT.........H.t.H...........h.........DH.....h.........G......u.........l........s......t......l.....h.......p........p......h......s.....h......s......h....h...h...s...t....t.t...t..t.h..h..ht...t.h...........................................................................................................................h..ht.p.t.t..t.h..t.h..t..t...h....t..h..h....h....h...s.....t...s.........s..........s.......s........s...t..........h..h.hhh..............................stt....p.....h....l..h..s.GD..hhh..............ttshhhh...................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	3453	6690	8675
+538	PF02652	Lactate_perm		L-lactate permease	Mian N, Bateman A	anon	COG1620	Family	L-lactate permease is an integral membrane protein probably involved in L-lactate transport [1].	19.70	19.70	19.70	19.80	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	522	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.72	0.70	-6.01	8	3338	2012-10-02 15:12:49	2003-04-07 12:59:11	9	5	2259	0	540	2191	157	490.80	36	95.93	CHANGED	LSALlALsPIlLFhhuLslhKhKGYhAuhlolAlolhIAlhha+MPlphshuSslhGhlhGLWPIuaIIluAlFLYKlSVKoGtF-II+pSlhuIosD+RlQllLIGFsFGuFLEGAAGFGsPlAIoAAlLVGLGFpPLaAAuLCLIsNTAPVAFGAVGIPIhusuusssls......................shEISphlGhhLshhollIPFalVhlhsG.a+GIK-saPAllluGhSFAlsQaLoSshLGPELPsIluuLlSLsshslFLKh.WpPKpla+.ssptpotsspst..........+hscllcAWoPFlLLossIllWs.PhFKAlap...psuhlhhssh.h.h..lsp....hlhphsPlss..puhshssVaKhcLlhssGTuIllAsllS.hhlh+lsspDshslFspTLKEhtlPIloIshVluFAhlsNaSG........MSsoLAluLAc.TGpsFTFFSPhlGWlGVFlTGSDTSSNlLFGuLQhhsApplGlsssLlLAANTsGGssGKMISPQSIAIACAAVGLsGKES-LF+hTltaSLIaslIsullshll	............................................................................hSuLlAh.lPI..lhhhlsLs...........h........h........+...........hK...........u...h...h.A.u.h.h.o.ls..lsl.l..l..Alh....h..........a........c.....M...........P.......s.........s.....h...u.......h...u.us.s.Ghh....hG........la...PIuaIllsAlalY+lolcoGpF-lI+so.l.h.u.I..o..s..D.p.R.lQhLlIuF.sFGu..FLEGAAGFG..sPlAIsAslL.luLG.FpPLhA.......Ahl.sLIuNo.APVAFGAlGlPl..hss...u..p...s....s...u...ls.................................s.h.p..luth...s...u..h.p...L...s....hhsl.l.l.PF..h...l.l....h....l....h.......s..........G.........a............+G...........l............+.......E............s.......a.......P.sh...l.....luGh...oFuls.Qal...su..s..a....l...G...PEL...ssIl...uu..L.lol..h...sl.s.l..a...hKh....a...p....P...c....p....h....h..c...h......t.....s...t.....t....t...t..t...s...p.hsh.....................................................shtpl..l...pA....WsPal.lLss..h..l.h.l.hs.h.......h...K..s..lhs........................s.hl..........h..h...t...........lpt.....h.hphs.sl.su.................h..s.....h.shphshl.u.....ssGTsIl.l.u.s...l...lo....hh.........h.........h.........+...........h.........p.........hp..p........s........hp.s........a..spT............l+pl.thsllo....IshllAhA..hlhs..a.SG............................h.ossl.u.h.u.lAp..s.G..s.hFshh.S.....PhL.GWlGs.FlTGSsTuSNsLFusLQt.s.sA.p..p....l......G......l............u.............s........s........L........ll.AA.N.osGGs.sGKMISPQSIAlA.sA.A.l.....uh.s...G+..E.....u.....c.....lh+h..T..lp..a..S...l...h...ah.hllullshl............................................................	1	182	344	454
+539	PF03798	TRAM_LAG1_CLN8	LAG1;	TLC domain	Bateman A, Finn RD	anon	Pfam-B_1398 (release 7.0)	Domain	\N	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.84	0.71	-11.57	0.71	-4.76	168	2246	2009-09-11 23:05:38	2003-04-07 12:59:11	11	31	362	0	1453	2051	32	191.70	17	58.71	CHANGED	casppshshlahhhsshhuh....hlhhpps...........................thht.h..........phhh....s....thh.hhhhphuYalhs..lhhhhh.pttpt...........................................................................h.hlhHHl.hslhlhshuhh..................................hshtph..shslhllh-hoshhLphs.......phhphh.th....................pt.............h.hhh...hhahls.FhhsRlh.....hhshh.....hhhshhthh...h.................................................................hhhhhhhhshhhs.L...pllplaWhhhllc	....................................................................................patpphhphhahhh.shhhuh.....hlh.hpps...............................................hh..h.............st..h...t...........h....p.hhhhhphuaa..htp....lhhh.h.h...chtcp..............-h...................................................................................................h.hlhHHl..hslhh.ls.huhh.....................................hsh.hph...s.sh.l.hh.l.t...-.ho.....shhLp.hs.......c.hhphh.th................................pt...............t.hhh......hl.hhhs.ahh.sRlh...........hhshh..........hhhs.h.h..h............h................................................................h.h.h...hh.h.hshh.hh...L.....hlplhWhhhlh..........................................................................	0	465	733	1095
+540	PF03161	LAGLIDADG_2		LAGLIDADG DNA endonuclease family	Mifsud W	anon	Pfam-B_3225 (release 6.5)	Family	This is a family of site-specific DNA endonucleases encoded by DNA mobile elements. Similar to Pfam:PF00961, the members of this family are also LAGLIDADG endonucleases.	25.00	25.00	25.30	25.10	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.90	0.71	-4.36	18	250	2012-10-03 01:41:40	2003-04-07 12:59:11	8	26	160	6	57	270	38	167.00	22	52.22	CHANGED	.hpllhGhLLGDualcpcs..pspp.......hphphphpp......tah.+hhhhhp..tasssss..hppphs..............ppGchhhshphpThsh.ssFshltphFYh...sspK....hhlPshlpp..aLTPpuLAaWhMDDG......p........sspulhlsTpuFohc-lphLhcsLpp+asLcsol+psp.......spahIal.spohthah	..............................................................hpllhG.LLGDup..lptps....ps..pp.......................hthp.phpp.........htah...a.h.h.hhp....thsp.p.....ht.ptht.....................s.p.htshpF..pThsh.spFshh.tchFY..........sstK...................hlP..p..p..l..tp..hLT.PhuLAhWhMDDG.........................ttsts.....lhlsTpsFo.hp-.h.hLhp...hLpppas....l.p.spl...pppt............tthhlhl.tpsh..h.................................	0	23	45	52
+541	PF04916	Phospholip_B	Laminin_A; 	Phospholipase B	Finn RD, Mistry J, Wood V	anon	Pfam-B_5721 (release 7.6)	Family	Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids.  This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast [1].  In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina [2].	21.30	21.30	25.10	23.50	18.50	20.60	hmmbuild  -o /dev/null HMM SEED	553	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.76	0.70	-6.39	6	390	2012-10-03 21:14:07	2003-04-07 12:59:11	8	9	163	6	279	416	25	411.50	27	85.60	CHANGED	p.hph..ullhhl.http..pshsss.....ppspsslshst.shp.................sth.stst......lAhupapssVNpTGWuhLEl-stp...shssplQuYuAGhLEGhLTtthlhhHhp.NohpshCcN...tspaCscLt-ahspN.+Whcppl.....pps.sD.aWpQlshslsQLsGLhsGYppRs.pscIshc....hasIhhhNhsGDlhDLt.........pphs+TcsPs........Fchs..G+CSA..LlKllPssc.......laFuHsThSSausMLRlhKpYcFs.......c.phsPGphloFSSYPGlLtSoDDFh.lpoutLsllETTlu..saNtpLh+phsP.spVhsWlRuhlANhlApsuppWsphFSRaN.SGTYNNQWhVLDh.Kp.hcspcpL..........sc..ssll...................allEQhPG.....hlsppDhTt..hLp+.oYWsSYNlPaaKplhclSGh....phscchG.aasastsPRA+IFcRDcusVTDlsShptLMRYNsYpc...-.hu+Cc..............CsP.PYoAchuIusRuDLNssuG............ThEh..u..GhssHuu.......lDsKs......sshcLh.......pphphhAh....uGP...shcslPsFcWsc.sshc-tssHhGpPDhWNFshVshK...........Wph	.................................................................................................................................h.................................................................................................h....t.h......GWs.lplts....................hs...s....hh..suGhhEu.....ho....h...h...N..h.h.....t.....h.t...........................th...t.l.pahttp.....tahppph......................t.....ps...aWtphthh.h...Q.hpGl.tuhtt......................t............................h.....hhp..uDl..D...l............................................h.t.....t........................h......sp..CSu..ll...+lh.ss.p..............plhhuHs.oWtsY.ts.hhRlh.Kpa.p..h.th.........................h...upphsaSoYP.Ghl.ShDDFY...l....h...s........s.........sLhhh.pTT..s...shN.t.L..h..p....l....p..s....t.slhtahRsh.............hAshhAps...u.tpWscha.t.phN..S..GTYNNQWh......llDhptht.......t...t.......................................thl..........................................................................................hlhEQhPs.......hh...tD.Tt.....L....p..sYasSaNhP.a.a.pl.hp..huGh.....................t.ph.u................h...pap....ssRu.IFtRsts..tl.......ts.hpshhthhRhNs.a.p...D.hu....tp.................s........IssR.....DL..ts....t.........................................................s..su...........hDsKh........ss.hthh................................tt.ht.hhsh....sGP....s...t...t.....ssFpW.....t..h.......+.G.Pp.apF..h......h................................................................................	0	154	189	239
+542	PF04031	Las1		Las1-like 	Wood V, Finn RD	anon	Pfam-B_10636 (release 7.3);	Family	Las1 is an essential nuclear protein involved in cell  morphogenesis and cell surface growth [1].	22.70	22.70	25.60	25.40	19.40	20.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.97	0.71	-4.56	26	316	2009-09-11 09:56:21	2003-04-07 12:59:11	8	8	274	0	222	321	1	147.90	32	29.95	CHANGED	slsW..tshpEhpplhphla..............sp........................................................s.sppccAlp+lp.sWpsRu.....plPtsl-uTuhLlpshLtD..............................................ssthsstslc...htYuhAllR.....FVNsllDstQp..uphshshpplApplGlPphhV-LRHtsTHcp.LPsLshLRhusppsLpWLacpYWppp	..................................ssWhshsEh.pVpphha..............sp.......................................................................................s.ptpppAlpplp..sWctRs........plP..hsV-uTA.LlpshLtD...................................................sst.hsp....tlp...hhYuhAl.sR.........FVNtls-t..hpt.....p...t...ht...h.shtplApp..lGl..Ps..hhV-LRHpsTHcp.LPuLshLRpusphsLpWLhcp...YWpp.............................................................	0	80	125	183
+543	PF00057	Ldl_recept_a	ldl_recept_a;	Low-density lipoprotein receptor domain class A	Sonnhammer ELL	anon	Swissprot_feature_table	Repeat	\N	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.59	0.72	-4.05	53	19728	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1237	198	54	11586	17417	67	38.20	41	15.75	CHANGED	ssCp.....sscFpCssup.....CIst.pahC...DGpsDCp.....DGSDE....psC	.............................h.tCt.......ssp.F.p..C......s...s.up.............C.....I...st...p..hhC....D..G..p..s.DCs........D..s..S..DE......tsC...............	0	3071	3990	7792
+544	PF02987	LEA_4	LEA; 	Late embryogenesis abundant protein	Griffiths-Jones SR	anon	Pfam-B_106 (release 6.4)	Family	Different types of LEA proteins are expressed at different  stages of late embryogenesis in higher plant seed embryos  and under conditions of dehydration stress.  The function of  these proteins is unknown.	36.00	10.00	36.00	10.00	35.90	9.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.72	0.72	-4.09	26	1180	2010-01-13 15:33:07	2003-04-07 12:59:11	11	27	134	0	431	1127	2	40.60	29	59.19	CHANGED	cDhsu-KAtEAKDsThcKsGEhKDass-KAtEuKDpss-KstEh	........................stpKAt-..s..t.......-ss...t...c....Ku.......u-.......s.......pDts....t-K....As-..sK-...tst...pth............................	0	117	228	375
+546	PF04004	Leo1		Leo1-like protein	Wood V, Bateman A	anon	Pfam-B_11226 (release 7.3)	Family	Members of this family are part of the Paf1/RNA polymerase II complex [1,2]. The Paf1 complex probably functions during the elongation phase of transcription [1]. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors [3].	20.10	20.10	20.70	23.30	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.34	0.71	-4.55	86	331	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	272	0	230	324	0	165.30	31	32.43	CHANGED	hahh+lPsF......ls.l-s..............cPFcPcoa.ts.p....................pt......................hpphh.php...NolRWRhsp..s........psGp...........tpSNA+lV+WSDGShoLplGs...Eh.aDl.......................................tppsh.tp.t........saLhsppst.........................................sllp..sputlspphshpPsoh....sStsH+..............phstulsp+ptpcstt....hhhtsspDPEhc+cctp+	.........................................ahl+lPNF......Lu.l-s..............cPFDPpsa.ts.t.p..............p..hscp.......................................................................ttp+hhhcsp...NolRWRhsp....s..........tpGp.h.........pcSNARlV+WSDGS..hoLplGs...E.h.aDl..................................................hptsh..p.sp............saLhlpps..........................................sh.Lp....s..p..uhhppplshp.Pp.os........sStsH+.......pho.hulssRstKppt.....thhh.sspDPEhp+pph.....................................	2	73	122	188
+547	PF00060	Lig_chan	lig_chan; 	Ligand-gated ion channel	Bateman A, Sonnhammer ELL	anon	Blastp NMZ1_HUMAN	Family	This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null --hand HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.03	0.71	-4.49	44	3260	2012-10-03 11:11:44	2003-04-07 12:59:11	21	78	277	465	1868	3242	57	253.80	21	33.83	CHANGED	oh-lWlslhhsalhluhslallt+.hoP.h-apt.........................................................................spaolhsuhWFshushht.pGsc...pP+uhouRllsslWahFsLllluSYTANLAAFLTlpchpss.IpuhcDLtpps.plpassht.uoohthappop.........hpphaphhpstps..........................ph.spssp-Glpclcpu..th.hAalhEsshl-ahsscp.......CchhplGp..shsspGaGIAhstsSPhpsplohAILpLpEsGclpplcsKWappp......pCsspsst..........sssspLslpshuGlFllLshGh	................................................................................................................................t..plW...h.h..l.hhs.h...l.h...l......u.h...l...la.l...l...t..........+....hss.hpapt.................................................................................................................tsph....s.l...h....s..u..h..W....a....s..h.u...s....h.h...............p.....p.....u.sp........hs..P.....+..u.....h.o..s.R.lls..............s.............l.Whh.F.s.......l.I...l..........luSY.TANLAA.a.LT...l...p....c.h...t...s.s...I..p..u..h.cDLtpps.hthhshtshsph.hhpppp.thhphhh.hh.ttt.t.hhtttttsh.thh...hhhh....................................................................................................................pp.pp.hh.hsth..tthhhhh...ts.ht.h.hhhhh..ptt.h.phhpchhhtts..tC.tptt...........tsstLslps.htGl..Fhllhhu............................................................................................................................................................................................................................................................................................	0	597	867	1417
+548	PF02900	LigB		Catalytic LigB subunit of aromatic ring-opening dioxygenase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	19.80	19.80	19.90	19.80	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.68	0.70	-5.41	47	3175	2012-10-01 19:17:44	2003-04-07 12:59:11	13	7	1832	5	918	2499	472	260.20	23	90.78	CHANGED	sshhhSHssshhhh.s.....sttph..t...ph......................ht.htppltp..h.............cP-slllhuscahs....phhss.hlssss................psltD........ah.......h.phphshsGss-LApplschlhtssls............spphslDHGshsPLphhhs..........shPll.lslss.....hhsspcphplGcultphht.....scpVlllGSGuloHplts.phs.............................................hstcaDchhlchlps....s...chptlhshpppt.ttttups.stchhshhhshGAhs...............phhsphhtatslsths..sshs	..............................................................................................shhluHu.s.sh..shps.........st.pt...........th..........................................h.th.t.pplst...................cPcsIll..h..........osH...Whs........phh.s..ls.s...ss.p...................................ps.laD.........as......th..P.t..h...hch..p..Ys.hsGsPpLAp..pls.ch...l.tt..s...s.lshth..............................p.shsl.D..HGs...h..sP.....Lhhh.hs...........................chc.lPl.l...p..lu......lss...........hhsstpphc...lGcslttht...........-csVhlluSG.s.ls.H..s.l...t....s......p.hstts.............................................................hs.tpFD.phlhphlpp....................s......ch.c...t.L...s...sh...h.p.......p..t..s..s.t...h..u...p...s...s...cchhshlhshGAhss.....................hphhs..chh.htshs.h.h.h......................................................................	0	265	556	770
+549	PF03893	Lipase3_N		Lipase 3 N-terminal region	Birney E	anon	Birney E	Domain	N terminal region to Pfam:PF01764, found on a subset of Lipase 3 containing proteins. 	21.10	21.10	21.10	21.50	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.44	0.72	-4.16	10	181	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	56	33	114	168	0	71.60	22	15.93	CHANGED	hlsslhslusupWuhph..............pcssaots-shspWspusssp...apshspss+shtsVasss....L+sPcltsshsshth	...............................h.hpth.shusApWs.t................plpaohtcshsp..WshussAth..a.s.hsphsphshslhpss....hpsPthts..t....t..........................	0	14	65	97
+550	PF01764	Lipase_3		Lipase (class 3)	Bashton M, Bateman A	anon	Pfam-B_893 (release 4.2)	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.84	0.71	-4.57	61	3914	2012-10-03 11:45:05	2003-04-07 12:59:11	20	76	1209	69	2118	4488	506	139.30	18	28.90	CHANGED	lluaRGTp..shtpahssh.phshsshp.h..............................ssplcpGFhcsap...................................thhpplhsplpc.Llpphs......s..hplhlTGHSLGGulAsLsAh.........lhppt............tplplhoaGsPRl...Gshsauphhs.................t...........hhRllpppDlVP+lPshhh	...............................................................................................................lsh+Go............s..ph....h.....s.h......h............h.........................................................................................tshsc.t.Gh.h..p..h.hp......................................................................................................h...h...p...p..l...h..p..t...l...pp.....hh.....p.phs.....................p..hplh..l..o..G.......HSL.....GGul...As..lhuh........................................h.h.t.ph...........................................hp.s.hs..F..u.s..P.t.l........s..s.....t.h.t..p.hh.p......................................................................hh.p.h.s...t........t..D.lshh....hh.............................................................................................................	0	783	1383	1855
+551	PF04571	Lipin_N	lipin_N; 	lipin, N-terminal conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4929 (release 7.5)	Family	Mutations in the lipin gene lead to fatty liver dystrophy in mice.  The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserved region is found at the N-terminus of the member proteins [1,2].	25.00	25.00	25.90	25.20	23.70	24.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.55	0.72	-4.41	10	549	2009-09-11 22:04:36	2003-04-07 12:59:11	9	10	268	0	306	483	2	107.30	51	13.02	CHANGED	MsYV...uuplasoVpclYsuINPATLSGAIDVIVVEQpDGoapCSPFHVRFGKh.GVL+ss-KhV-IplNGp.sDlpMKLuDoGEAFFVcEs.--p.pclPshLsTSPlsssssu	....................MsYV....tplhsoVpc.h.ap...ulNsAT..L.SGsIDVIVVc.......Q.............D..G......o.......hpCSPFHVRFG..Kh..GVLRucE..K...l......V..-IclNG.....ps..l..D.l...pMKLG.-sGEAFFVpE.s....-.s.p........p....lPt.LtTSPl.s...s.....................................................	0	91	150	231
+552	PF03180	Lipoprotein_9		NLPA lipoprotein	Mifsud W	anon	Pfam-B_1418 (release 6.5)	Family	This family of bacterial lipoproteins contains several antigenic members, that may be involved in bacterial virulence. Their precise function is unknown. However they are probably distantly related to Pfam:PF00497 which are solute binding proteins.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.38	0.70	-5.46	35	6507	2012-10-03 15:33:52	2003-04-07 12:59:11	9	8	3244	23	955	4106	60	229.70	38	86.36	CHANGED	lplGshssscu-lhc..hlpphhKccs.lclclhpFoDYspPNpALscG-lDANhFQHhPYLcphs+s..pttpLVslussalpPlulYS........+KhKsls-L...cGusIAlPNDsoNpuRALhLLppsGLI+LKss.tshhAThpDIs-N.PKsLcl+..El-AutLPRsL-s..VDhAlINssYA.lpAsLsPpcDulhhE.s+.s..uPYsNllVsRp...ssccsstlKcllcAhp.oc-V+phlpcp...a.sGuslPua	............................lplGss..s.s..s..c..s..p..lhc.....hsp..p..h.h.c.c...c..G....lclclhpF.s.D.YshPNpALscG-lDANhF..Q.H...h...P.aL..-p..scc.....+.....Ghc......L..s.s..l..u.s..s.al......P...hu.l.Y...S..................+K...h..K..slc-l......c..Gu..p......l..AlPN.D.soNtuRAL..h.L..Lp.psGLI+L....K....ss....s....s......h....h......u..T....s..t...DI...s-....N....PK....pLKhh...El-.AuQlsR....sLsD....VDhA..l.I..N.s.saA...hp...u...G.L.s..P..t..c............Du.lhh.E.......sp...s..........s..P..Y....s.Nl.l.....ssRp.......sscc.s.pt....lKc.llcs.ap.Sc-Vpchlpcp...a.pGuslss...................................................................................................................	1	211	490	731
+553	PF02190	LON		ATP-dependent protease La (LON) domain	SMART	anon	Alignment kindly provided by SMART	Family	This domain has been shown to be part of the PUA superfamily [1].	21.90	21.90	21.90	22.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.53	0.71	-4.65	158	5691	2012-10-02 17:37:24	2003-04-07 12:59:11	11	68	3513	13	2086	4772	4482	199.10	23	30.32	CHANGED	plPllPLtshl.l.aPshhhslp.lt..csp............hp......hlcpsh.......................pp.st...h...lhlh.....................................................ptp........s.......t.ssl..................................................aplGsl.....upIhp.h.....................phs..c..Gp..................................................hplllp..Ghp.Rh+l....pph................................................................................ppsa....h...............huclp.h..........................................ptptpptt.......ptltph...hpp..................................hhp.h................................................phhpth.s.phh.t.hpshppssp.Lsshl...ush.ls....hshpc+Qp.lLcthsspcRlptlhphLpp	.......................................................................................lPllPL...cshl...l...aPthh...lPLh..ls....ct+s..........................lp.h.lcpsh...............................................pp..s..pt......lhls...............................................................spp.ps...t.p..ts.........s.h.s..cl...............................................................................................................................a.plGsl...upIhp.hh................cls......D...Gs..........................................................................lplllp...Ghp.R..h+l.........tph........................................................................................................................................................................t.pcsa..h.................................................tAcl..p.hl............................................................................tttppt.t..........ptl.tth...h.t.p....................................................................................................................................................hhpth.............................................................................ph..p.ph.....s........c....h....h.t..s....h.p....s..h..s.c..ss....p..L...u...Dhl.......Aut..hs.........lph....p.c.+...Qp.lL....Eh.sl.....pcRLchlhthh..t..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	700	1277	1725
+554	PF00560	LRR_1	LRR; 	Leucine Rich Repeat	Bateman A	anon	Reference 1	Repeat	CAUTION: This Pfam may not find all Leucine Rich Repeats in a protein.  Leucine Rich Repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations.  These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.	20.60	9.30	20.60	9.30	20.50	9.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.84	0.76	-7.83	0.76	-3.07	2414	25597	2012-10-02 21:32:02	2003-04-07 12:59:11	28	4912	1389	82	13545	96601	2712	23.30	33	5.68	CHANGED	pLppLslss..N..plp.p................lst...htph	.....................pLphLcLSs.N..pLs.p................................lPs.p..ht......................................................	0	2975	8467	11049
+555	PF01463	LRRCT		Leucine rich repeat C-terminal domain	Bateman A	anon	SMART	Family	Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.	20.00	4.20	20.00	4.20	19.90	4.10	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.26	0.74	-7.54	0.74	-3.10	59	1112	2009-09-10 23:15:08	2003-04-07 12:59:11	19	248	79	18	530	955	2	25.80	34	6.10	CHANGED	shhCssPsthps..lhphs......phsCs	....sRCsuPtpL+shpltplp.....pcFpCp.....................	0	82	113	266
+556	PF04180	LTV		Low temperature viability protein 	Wood V, Finn RD, Mistry J	anon	Pfam-B_15065 (release 7.3);	Family	The low-temperature viability protein LTV1 is involved in ribosome  biogenesis 40S subunit production [1].	25.00	25.00	26.50	26.60	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.55	0.70	-4.97	4	274	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	231	0	202	269	2	368.80	26	86.00	CHANGED	sKKpAppFpLVHRsQcDP.haDEsAsp+VLlPspp.N..Kou...shpspDtp.s...shRspcGEAApYGlaFDDoEYDYhQHL+slGpssusulhlsupshspp.cpK......ctpc.h.hpspspcL..p-shhsphphph....shtsQQs......sPDtIuGFpPDMDPcL.......REVLEALEcpuhshND-E.s.--...........DucEhc-hDhp.........tthDEh-D.ut..s.p..cs.cc..a..s-E.sch..h-hspsupshshps-hpht.cca...chhpK+psDst.usus.u-hpsS.ppDs......l.-h.po..pKu+s+pKtuAhoshSshSMSSSALsRoEsholLDspa-clcEc.........Ysshh--hp.lc....................Qs....sVhsc....tppF-sMhD-FLssatsp......sRphucp+hcpp+hKpul-ElcchR+s.t+ARh	.............................................................................pKKpAhpapLVHRuQpDPLht.DpsAsp+VLh......s..s.....................................................................t.................p...t.p.....................t...t.pcuEttpYGlaa.....DD..c.YDYhQHL+...........t....p.sss....s.hlt.sts.....ttp....ctc...............................ph.c..............t......t..........p......l.............ss...s......h.h.Sp.hppth...........shts...s.........sPD.lAuhps.D..h....D...c..............c..lLpA..cspsh....t.t....-..p.t.....pp..........................csp.Ehp..-...-.....t.............................t........t....p.-..p.p.t..........p.t................tt.....t..p.....a............c.-...s..p.........t........hp..........s.s..ss.s..h...p.h....s.tp.hh..h..pcF................c+.....c......p.h...s.............t...h.........u..sh.s.....s.....c....h.p.s.............p.........t...........s...s..................h.......ph..t...............pttc.....pp...h....+....h......ssh.ps............p.....s..........h.......s.hs..sst.h..cs...Et...ph.....l.ssph-..php.pt.........................Y.sp............p...c..p..p.....t.................................ps..s.sh.st.......tp...p...hpp.h.......pt.....ss.....p......................R.hsc..p.p..t.cp.tt.h.ppuhcp...pc.+t..t.sp.............................................................................................................................................................................	0	68	104	163
+557	PF02123	RdRP_4		Viral RNA-directed RNA-polymerase	Mian N, Bateman A	anon	IPR001795 & Pfam-B_6212 (release 8.0) & Pfam-B_9867 (release 8.0)	Family	This family includes RNA-dependent RNA polymerase proteins  (RdRPs) from Luteovirus, Totivirus and Rotavirus.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.79	0.70	-5.78	28	1146	2012-10-02 12:54:00	2003-04-07 12:59:11	11	8	405	10	1	4591	0	427.20	31	60.01	CHANGED	sphhstspphhtphhshpttstsst+sslp.tplhtsthpphsps.........sth..shhphhh..............................................................ps.h.shh..............hh.......................................h.......ht...............................................tss.p.sshhsphpsl.G+hssshc.......hptEhpp+sssslsh.thsptspctl.......hshltplhppcl.................................p.h.tp.....ttt..............pthhpsc..hh..tsschs++sls-s......lchh.sptcscst........h..tpKl.Ep................................G.+sRhIh....usshlsalshchlhtstcc.........th.supshlshssttphhshtpcl.............hpttt.hhhhDhosFs.SpHshcshptlh....p.hpppls.shshttt..........h.h..hhpshtshhlhlsss..htp..........chhGslhSGp+sTohhNSllNhshhphshuthshsh.........ps.GDDslhuhpss..............hhcphpphsh+spshKpshu..tuE........FhRht..............hpptshtu..a....................lh..RssushloGsW	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...h.h.s....ph...............php.c.s.shs..th.t..tp............h..l.thh.p.l..............................................................................p.h.psp........h........s.phscphLt-s..................lph...sttpsc.p...................tK...c..............................................................................................G..+hRlIh......ph.lsp...phl....h.chhh...tpc.............h...t.p...hhs.........s..s.......t..p..h..........t.l......................h..hDhotas.S...p....sh....cch.....................lps.hh...s........s..ps..psh.........................p.Lh.t.t.h..hs....l....h.......sS...h.l....p..lsD.Gs..lltp....................................h....GshtSGphpTpusNSh.h.....p.....l...h...h....h...h.........t.....s.....h..........u.....p......h.....u...th........................................GDDshtshp...s..................hthYtp.h.s.hK..scs.............................................................t...thh....a.........................p.....................................................................................................	0	1	1	1
+558	PF01476	LysM	PG_binding_2; 	LysM domain	Bateman A	anon	Bateman A	Domain	The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation [1].  This domain may have a general peptidoglycan binding function. The structure of this domain is known [2].	20.90	11.80	20.90	11.80	20.80	11.70	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.96	0.72	-4.06	156	27194	2012-10-01 23:00:54	2003-04-07 12:59:11	15	602	4537	7	7042	21185	3954	44.30	31	16.15	CHANGED	apV+pGD..TLhpIAppa.....................shshpplhphN..........slsssp.....lhsGQpLpls	....................YsV.pp.GD...o.Lhs....I.A.p.ca.........................ss..s...hp...p....l...h..p....h..N....................s..l...s....ssp..........lhsGQpLpl..................................................	1	2348	4523	5983
+559	PF03466	LysR_substrate		LysR substrate binding domain	Bateman A	anon	Bateman A	Family	The structure of this domain is known and is similar to the periplasmic binding proteins [1].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.20	0.70	-10.87	0.70	-5.23	415	85941	2012-10-03 15:33:52	2003-04-07 12:59:11	15	39	4494	158	20277	62785	6990	202.80	15	67.81	CHANGED	pst.pG..pL+lus..sshu...tthlsshlspFpp.p.aPt.....lplplptss..tplhchltpGplDlulhht.............tsssltsp.Lh.ppphsllss...ssa...............Lsp.......ttsl.shpcLtp..pshlhh..p..sss.......hpphhpphhppt......shp.........phthpssshpshhphltsGhGlullPphhht..p.h...tpsplh.hslss.........sht.tshhllhtpsp..h.ss......thpshhchltp.ths	......................................................................................t....pG..plplu.ss...s.s.hs.....tth...l.s...s..h...l.t.p..a....t..p.......p.....a.....P..p...................l..p...l....p.......l.....t...........t.......s...........s........................p..........h.....h......c..........h............l..........t.....p.....s.............p....h..D..l..u...l..t..h..tsh.................................tss.s.l...t....s...p....L....h....p........p.........p..h..h.hl...s..s........ss..a...........................................................l...sp..............ttsl...s....h.....p...c....L.....t.........p.......t..s....h....l....h.h.....p...t..sss.....................hpp..hh.p....p...h....h..p.pt...................sh..p.........................pht...h...p...s...s...s...h....p...s....h...h....p..h.l......t...s......G......h......G..........l......u..h...l..........P....p...........h........h.......h....t...........p..h..........t.p.....s.......p..........L.......h........h.s.l..st.........................tht...hs..h..h...l....h...h...p.....p.....p....p..........h....s.s.......thp.thhphlht...t.......................................................................................................................................	0	3804	9358	15032
+560	PF03816	LytR_cpsA_psr		Cell envelope-related transcriptional attenuator domain	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.81	0.71	-4.30	37	6551	2009-09-11 05:59:27	2003-04-07 12:59:11	9	20	2068	19	1112	4741	444	152.40	32	38.41	CHANGED	RoDohhllplssppcpsphlSIPRDohVpl............ss........p........hpKlssAhshG..................usphshcTlcphhu.lslDaYstlsapuhtpllDslG..GVcVssspshp.........sst.........................................hphpsGpppls.GcpALsasRhR+sss.G.....DhuRhcRQppllpulhpchts	.....................................................................RoDohhlhslss..p.s..c..p..s..pllSlPRD.o.h.lp.Is...........................sh.............p.............tsKlNtAa.shG......................................Gsph.shcTl.cp.h........h...s.......l...s...I...-....aYsplshpuFtcllDslG...GVc.Vss.......sh.......s..hs...........pss...............................................hp..h.p.t.G.....p....p.....p.Ls..Gcp.ALs...asR...hR..........p............ss....s.....................G............Dh.........s....R.tp..RQppllpulhp+hh.s..........................................	0	408	799	997
+561	PF02847	MA3		MA3 domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain in DAP-5, eIF4G, MA-3 and other proteins.  Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains [1].	20.70	20.70	20.70	20.70	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.14	0.71	-4.37	29	1720	2012-10-11 20:00:58	2003-04-07 12:59:11	12	37	326	24	1096	1714	25	110.00	21	15.93	CHANGED	h++chttllp.EYh..tDhpEAspsl.pcLths..phctclV+hhlshsh-c....pptpchhuhLLpchhptshlsspphppGF.chhs.sh-DlslD...............lPpshphlupFlu+hltsshLs	....................................c+plhhhlp.phh........D.hpEAhppl....pc.L....ph......s.....p......hp.....t......c..............l................lph.hlptsh-c...........pphpchhuhL.lppL.s.....p..t......s..h....htppp..h.ppuFh.chh....c...ph...c..-...l.tlD....................................................hs.thp.l.uphhuchltsshl..........................................................	1	344	582	853
+562	PF01454	MAGE		MAGE family	Bateman A, Wood V, Finn RD	anon	Prodom_3141 (release 99.1)	Family	The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown.  This family also contains the yeast protein, Nse3.  The Nse3 protein is part of the Smc5-6 complex [2-3]. Nse3 has been demonstrated to be important for meiosis[3].	25.00	25.00	25.80	25.30	20.80	22.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.39	0.71	-4.97	47	1361	2009-01-15 18:05:59	2003-04-07 12:59:11	14	13	248	3	734	1407	0	168.80	36	45.07	CHANGED	LVpalLhK.ptKp..PIp+u-hlctVl+ca.......+cpF..scIhpcAucpLchlFGhcLpEl-sp.............................................................s+sYlLlspLshs..................ssh..lsss...pshP..............................+sGLLhllLulIahpGNpssEpplWchLphhGlhss.c....cH.laG.-s+KLl.........op-hVppcYL.cY+.plssocPscaEFh.W..GPRAhsETSKhKV	....................................................................................LVpaLLhK.ptKp...PIp+u-ML..c..lhcca........cchF...PpIhp+AspplchlFGlcl+ElDsp..................................................................s+sYlLlspLshs..........................................ssh...lsss..pshP..........................................+sGLLhhlLulIFhp......G.......N......pusE...........pp.....lWchLp.t...h.G..lhsu..p...........cH.laG.-s+...+Ll........................................Tp-hV.ppp................YL.c...Y...............+....p.............V.............P..s....Sc..............P...........s..c..YEFl.W..GPRAhtEToKh+V....................................	0	103	147	224
+563	PF00390	malic		Malic enzyme, N-terminal domain	Finn RD	anon	Prosite	Domain	\N	19.20	19.20	19.20	19.20	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.02	0.71	-4.70	48	7633	2009-01-15 18:05:59	2003-04-07 12:59:11	14	36	4079	97	1959	5725	2415	136.20	38	27.44	CHANGED	ps+pEhlah+hlpsp...-.hPllYTPsVupsCppauc.hcpsp..hahohssht...h.t.h.th.......plhVlTDGstILGLGDlG.huGhslslGKhsLasshAGlcPt.slPlhLDsGssp.t.hts..YhG....R..s....thlDcFlcslpphasspshIpaEDhusspAFplLc+a+	.................................tc.phh.hp.ltsp.....c.LslsYo.PsVutsCpphsct........pp.s.............h.....hahsh.s..sh............................................................VhV.los..Gp..u...lLGLGslG..huuhs..............l........GKhs.....La.............p.....thuGl.c...s.....hsltlDst..............................s-chlpslp..th..sh............uhlph..EDhtsspsF.l.p+h+.............................................................	0	602	1170	1596
+564	PF03949	Malic_M	malic_N; 	Malic enzyme, NAD binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	23.50	23.50	23.50	23.50	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.45	0.70	-4.83	66	6923	2012-10-10 17:06:42	2003-04-07 12:59:11	10	36	4103	83	1803	5218	2322	236.30	38	43.02	CHANGED	.QGTAsVslAullsAl+lsucs...l......p-h+lVhhGAG..uAGlulschlhpt.....Gls....t...cplhhlDpcGllpcsR.ss..h......s.....shptt....aA+ppsphp.............hsLt-slcss..slllGsSt.ssGshsc-hlcpMup.........+PIIFALuNPss..EhpP--Ahphssutsl.ATG...........+o.hPsQsNNslsFP..GlhhGslsspAppIs-cMhhAAAcAlAshsspc..............phst.shllPshtchR.luhplAhAVuctAh	......................pGTAlVshAullsAL+....l.s....u+p..............l..............p-...h+lVh.GAG..uAGlu...hschllsh.........G..lp............hcplhhsDp..................p.....Gllhcs..R....s.s...L........s......thppt...........aApp.s.st.t.................................toLt-slcsu..Dlhl........Gl..........S....s....ss...s......hopEhl+pMup..................cPIIFALuNPs.....s..EhhP.cp.Ahphss...sts.hA....TG..............................................R..o.........t....a..PsQsN..N....sLsFP....GIhhGsLss.tA.pp.Is...--Mhh.AA..u.c...........AlA.phsp...t..p..........................ph.u.....s...hllPpshD......R..l.hplA.AVAcsA.....................................................	0	555	1086	1472
+565	PF00629	MAM		MAM domain	Bateman A	anon	Prosite	Domain	An extracellular domain found in many receptors.	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.29	0.71	-4.46	92	3415	2012-10-03 19:46:52	2003-04-07 12:59:11	18	308	158	2	1950	3145	308	149.40	23	28.95	CHANGED	CsF...Eps.....hC.uappsps...ssh..cWpp.hps.ss.......suPttD+ohss........Ga.ahhlpssts....ttGp..........pA.pLhS.hh........stss..........stC.lp.FaYah.hGpsh....Gs.Lplhlcpp...........tsttph.....lWph.sGspu......spWppsplslss....sppapllFEu.htus..stt.GslAlDDlplp....ps....tCsp	.........................................................................CsF.....-ps......hC..s...ap....p.......ttt...............ssh.....pWph...ps...s......................sP..hDpohts.........................Gh.a..h..h..lpssts......t.up......................pA..pL.h.Sshh.....stss.......................stC...lp..Fa.Y.ah.....h.....Gtsh......................Gs...L..p..l.hlptp..............................tth.tp.h.....................lW....ph.....s..u....s.p.u...................stW..p..p.s.p.ls.....lss.......sp.....ta............p..l..lF...c..u...h.hst................s.t...us..lA.lDDlplt..t.....C..t........................................	0	938	1052	1428
+566	PF03999	MAP65_ASE1		Microtubule associated protein (MAP65/ASE1 family)	Bateman A, Wood V	anon	Pfam-B_12512 (release 7.3)	Family	\N	21.80	21.80	22.50	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	619	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-13.08	0.70	-5.92	6	605	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	273	3	390	587	4	449.20	20	74.33	CHANGED	hpssplsclcpcspsshpctccEs..sptppullppIustcsElssL...........sphLc.......................................tthshhpp.cshshh....+Lccpl-pL....................RcphspRhsElpELhcQ.ppLCppLGp.sLsh.........h-sssLs.....Ech-phRp+lspLc-p+spRLc-hssl+psIpphhchLspp.t....sshEpclhs............ss+slo.EshspLpphhcphpsp+pcpt-+lcslpsplppLWsRLphosE.tp...............hp-Aoshoppohcl...lccElpRLptlKppplKphIEphRlEIpEhWDphhhSpEpR+p..Foshap-hhs........EpLLEtaEsElccLKphhsspKcIh-LlpcatpLhcchctLEtpusDsNRas.sRG....Gp..L.LKEEKpRKplsp+LPKlpppLptclpsaEscpspsFLhcGpslLEhhu.......spWEc+RppKppupspKKsssppss.hcss.ts..sssPpTPssp+sstslsssTsuht+s..hppsppptpsossstpoGsh+p+ssspRh.ssssp.suAppuptssh.RsttssssuptssSssptp.pos.sshhhspshshshcpssspsphpssspsspptcslppspsusssps-soostpsu	......................................................................................................................................................................................................................t....................................................h..............................................................................................................................l....hp..h...............................................................tt.ttpRhpph...tt...l...tt...p....p....h......pt..............................................................h.t...t.s.ls............pplpphptplppl....ppchp.pRhpph..phh...pplhph...ht...Lsh.s.............p.ht...t......h..t.............................................................tt.pths.l.sp....pslt.pLpphh...........ppLpt...p+ppp.pp.....h...........pplttpl.pLW.phh..p...h..s...tp-pp...F........................................h.tt.s.t....s....hs....h...phlpt...........hp.ElpRLppLKtp..ph+ph...l.p.......h+..-lpphhcth.a......h....s...-...p...ttt.............h.....h...h....h.....-.s.hs....................................p...p...L...L.p.h-.tpl.tclcp.hts++plhchlp+a.phhpc.p.LEp....hs.pDss...........Rat...sRG........up........L..L+ct.cpt+tlh...pc.lPt..l.ppLt.tp.lptWE....p....cp.......s.p...s.......F.h.h.pG.....phlphlp.......................h...p..t.p...c............p.+.......p....p........+...p............p.+...p........h....t....t.t..............t...t...t.p.............t..t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tt..................................................................................................................................................................	0	110	216	309
+567	PF00917	MATH		MATH domain	Bateman A	anon	Pfam-B_1602 (release 3.0)	Domain	This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans [3].	21.20	10.00	21.20	10.00	21.10	9.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.59	0.71	-3.86	52	3261	2012-10-02 00:06:50	2003-04-07 12:59:11	21	124	446	92	2107	3079	7	124.00	17	25.90	CHANGED	lcNhSphp.......pspphhs.shpp+ashsWp................lplhppss.......ahulaLpCtpt..ps..........hpWslpschplpllsssGpp.........hppphp.....psFsps.................................hshGhsp.....alpacplppch...lhcDolhlcupVcI	................................................................................ht.h...............thh..s..s.h...h.t..h..tG...h.p...Wp..........................................lpla.pGss................pssalS.l.alpl..h.ps.t.ps.........................tWsh.p...s..p...h...p..lpl..ls..p..p..spp.................ptp.p...........ppF.s.pt........................................................................................psh.G.atp...........Fhp..hp.pl....p.ptt.......a..l....h..s..D.s.lhlpspl..........................................................................................	0	726	1040	1659
+568	PF01429	MBD		Methyl-CpG binding domain	Bateman A	anon	Bateman A	Domain	The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [1].  DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [1]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.56	0.72	-4.45	16	1074	2012-10-03 08:51:45	2003-04-07 12:59:11	14	66	135	6	573	1046	14	75.90	25	10.19	CHANGED	hpppp.tcssL.tGW+Rchh.RpsGpph....................s+hDlhYhu...........P.sG++h+ohs-lhpYLppss...............................................hphppFsFssthhhsp	............................................................................................t.......p.sL..GW.pRchh.....R...p..t...Gt.ph.......................................tch.-lhYhu..................................P...sG+.chRoh..s-l....hcY...Ltp.ss...............................................................................................h..ppFsFpsh.....hht........................................................................................	0	130	240	380
+569	PF03062	MBOAT		MBOAT, membrane-bound O-acyltransferase family	Bateman A	anon	Pfam-B_2359 (release 6.4)	Family	The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue [1].	20.90	20.90	20.90	21.00	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.26	0.70	-5.31	41	4677	2012-10-01 20:09:06	2003-04-07 12:59:11	14	27	2309	0	1785	4135	489	287.90	18	62.65	CHANGED	hhthhhhthphhslhhhhslshhshphluhhhphtcs..................................................................................hhpthshhcahsYlhahs...................shhsGPhhpapcahpthc.t..hphthh..................t.hthulthlhhshhhhhhhthhlshhhhthlphhthhp......hshhhhhhhhhhhthhhha...th.hhshuhshhhGlt....................................ts.sh.psh.tspshpcahcpWphslspWLtcYlYhphh...........hhhtphhuhhhsahlsulWHGhphtallashhpslhlhspphhtphhphhthtttttththhthhhthhhhhhhshhhshhhh	..............................................................................................................................................................................................................................hhh.............thhh.hulsh....h....o...h......p.l.shh...h..-hhc..t.............................................................................................................................................................................................................................................hhtphsh.hpaht.al.haaP...................................................................plhu..GPlhcapc.hh.pp.h..p....p....h.p...ph..........................................h.t.t..ul.t..h.l....h..h..G.h..h..h.c.hl..l.......u.........h......l.s....h...h..h......h..t...h...h...p..t..........t...........................................................................................h.......h....h....h.h....sh...h...ta.s..h........l.....a..h.cFsu....a..s...h...A.l.uhuh..hhGhp..................................................................................s..NF......psa.h.u.psl..p-F...W.p.+WHholspWh.+..cY.l.Yh.hsh................................................pp.thh.t...p..h....h....s.....h.......hl.sah..lsul.WH.....G..h..........s.h.t..a....l............l..........a.....G..h...........h....p..u.h.hh..h....h...tp..h....h...h....p........h....h....t......h................h...................t....t...h....h...h.....h.....h..........h...h..h..h...h.......h.h.hh....h.......h......................................................................	0	630	1009	1447
+570	PF02820	MBT	mbt;	mbt repeat	Bateman A	anon	Pfam-B_526 (Release 6.2)	Family	The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.	20.20	20.20	20.30	20.60	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.19	0.72	-4.06	18	2104	2012-10-02 16:56:36	2003-04-07 12:59:11	13	50	103	159	1180	1975	0	72.60	33	29.03	CHANGED	MKLEAlD.pssphlClATVspVhGpc.Lpl+aDGacsph....DaWsph-.SsDIaPlGWC-tsuctLpsP.shtppth	..............................................................MKLEul..D......p...s..s....p...h.h.p..lAT.V..s.cl.......h....upc...lhl.....+.....a..........D.G....h..c...ssh....................DaW...s.phs.S.scIaPVGWCpps..G..p....Lp.PP.sh.....h...................	0	218	298	671
+571	PF02470	MCE	mce; 	mce related protein	Bateman A	anon	Pfam-B_475 (release 5.4)	Family	This family of proteins contains the mce (mammalian cell entry) proteins from Mycobacterium tuberculosis. The archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage [1]. This family contains proteins of  unknown function from other bacteria.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.65	0.72	-3.98	125	12284	2009-01-15 18:05:59	2003-04-07 12:59:11	15	19	2490	0	2643	8745	850	86.00	22	29.09	CHANGED	sshplpsthssu.sGLpsG.ssVphpGlpVGpVps..l.............p.sspp......lplphplp...............................................psh............................hlspsspuplpst.sll.Gt........................................palslpss	.................t...plphphs.su..sGLp.sG..ssVphp..GlpVGpVpsl........t.............h........ssss.pp....................lplph.plp......................................................sph.................................hls.p.ss.p...u.slps...sll..Gt..........taltlp..........................................................................................................................................................................	0	540	1469	2139
+572	PF05053	Menin		Menin	Moxon SJ	anon	Pfam-B_5848 (release 7.7)	Family	MEN1, the gene responsible for multiple endocrine neoplasia type 1, is a tumour suppressor gene that encodes a protein called Menin which may be an atypical GTPase stimulated by nm23[1].	19.20	19.20	19.70	19.20	18.70	18.40	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.08	0.70	-6.35	3	147	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	84	8	78	156	0	425.50	46	94.18	CHANGED	MGl+usQKoLFPLRSIDDVVpLFcuELsSs.EPDLsLLSLVLGFVEHFL.........AVNRVlPVNVP-loFpPosusDPsuGNSs.FPVV-LsLIAALYcRFpAQIRGAVDlSpYPKPuGsSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSaIT.....GTKLDSSGVAFAVVAACQlLGLKDVHLALSEDHAWVVFGpsGEETAEVTWHGKGNEDRRGQTVsAGIsERSWLYLKGSYM+C-RsMEVAFMVCAINPSLDLHTDSlELlQLQQ+LLWLLYDLGHLERYPMALGTLADLEElEPTsG+.SPLoLY+KAIESAKTYYRNEHIYPYMYLAGYHsRpRcVREALuAWA-AAoVIQDYNY.CREDEEIYKEFFDIANDVIPsLLKEsASutEAc..-Et.tEpp.tptuthSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATaLVQSLoRFDuQIRQKVsIlo+E..................sEAsEu-EsuGEEAREG.RRRGPRRESKs......................................-EPuGutSPNPcLPApNpNssospsuss.GucRKsuAoTsGsAssscNGSoosVPlPouSpP..................PphptG..................PVlTFaSEKMKGMKELLlAsKlNSSAIKLQLTAQSQVQMK...+QKsSAouDYTLSFlKRsRKsL	..........................................................................................ttthFPlpshssllplFtttLt......p...EPDLsLLSlllGhlE..L..................s.stshsss.....sth....t....................sh...FPshphphltuLYt+F.s....hls..h....s.h...t....tt.uoREllKKVSDVIWNSL...RS.aKDR.AHlQsLaSalo..........GsKLDs.GVAhAVVuuCQhLGh+........DV+LAlSEDHAWVlFG...p.t.pThEV.TWHG..KGsED+RGQslt.........sGl.tpt.SWLYltG..hhCsR.tMEVAhhVsAlNsSl.......shpo....DshElhpLQQpLLWlLYDhGaLc+YPMALGsLu-LE-...ht..........o...............s.....................p.ss...platcultuuppaYp.spHlYPYhY.usa.h.R......h.hp-....Ah......tsWAps...upVhp.YsY.sR-DtEIYKEhh-lAN-lIP.hh+.ts....p........................................phLppspsau.lLpFYDGIC.WEEsu.TPlLHl.sWAp.Lltsls+Fp.plRtpl.l....p..........................t..t...t.................t.........ps....pp.................................................................................................................................................................................................................................................................h...........................................sh..l.h.StKMtsh.thl..s.t.+lNstA.htL.lTAQS.sp................................h........................................................................................................	0	32	35	60
+573	PF00149	Metallophos	STphosphatase; 	Calcineurin-like phosphoesterase	Dlakic M	anon	Dlakic M	Domain	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.44	0.71	-4.92	324	31320	2012-10-02 19:15:56	2003-04-07 12:59:11	23	436	5141	215	11462	33578	5742	205.20	13	48.44	CHANGED	hplhhhuDlHsphtph.............................................hthhphttptpsshl.lh.sGDhsspsthshtthhhh.....................................................................hhthphst.hhhlhGNH-htthsphhhhh.th............................................................................................................................hhht.thhthhhphhshh.htthtshpllhsHssh.stht...........................................................................................thhtthhtptphchlltGHpHt.	..................................................................................................................................................lhhhuDl.H....h.p..htth.......................................................................................................thh.h...p...h....t...t.....p.........t...s.......s.....h........l....l.........h....s..........G.D....h......h......s........p....s...s.........s....t.s.h.thh...........................................................................................................................................................................hhhh..p..h......t............h..h.....h.....l.h...G..NH-....h.t....h.......h....h.....t....h....h.....t..........h.......t.....t...h...........................................................................................................................................................................................................................................t....h.....h.....t......h......t..................t.............h......h............h......h................h......h...............h......t.........t........................p......h........h......l...........h.....h............s.......H......t...s...h......s.t....................................................................................................................................................................................................................h..........t....................t.....h.......p..h....h...h.h.uH.h................................................................................................................................................................................................................................................................................	0	4014	6855	9602
+574	PF01420	Methylase_S		Type I restriction modification DNA specificity domain	Bateman A	anon	Bateman A	Domain	This domain is also known as the target recognition domain (TRD). Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification.  The host genome is protected from cleavage by methylation of specific nucleotides in the target sites.  In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity subunit (this family), two modification (M) subunits and two restriction (R) subunits [2].	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.11	0.71	-4.27	65	11631	2012-10-02 00:09:28	2003-04-07 12:59:11	14	41	3019	14	2039	9932	1120	165.50	14	72.39	CHANGED	s.cWc.phpLs-lhcl....tpGpt.tpp..phtpsGph...........Palsss.thps...............thhsttpphhhp.tsslhlstp........u....shGpshhtst....t.....h..hssp..phtslpsh..ph.h....chhhhalt....thhp......phpp........thussh.plstsplp..phcl.lP.......sh.pp......QptIschlcphtp...plpp.phhpplcp	.................................................................................................................................h...hpl..t...p....l.h..p.h...........t...u..t...t.......p.............t..t...t.s..t..h.....................................shl.phs.....t.............................th.....t............p.....p.....h..........h...h....p.....t.....ss....l.l..hstt.......................u..sh.G..p....s...t..h...h..pt.............p...............h.....h.h.s.p....t.h.hhl...psh.....ph...............p.a.l..hhh.lp.......th.hp............ph.p.ph......................sp.u..s..s..h.....p..l...s..t...s..p...lp.....p.h..l.s..l.P..............sh..pE.................Q....pc.Is....p....h....l....p....p....h....tp........th.t..........t..................................................	3	744	1450	1786
+575	PF01795	Methyltransf_5	DUF36; UPF0117;	MraW methylase family	Ayala JA, Bashton M, Bateman A	anon	Pfam-B_1376 (release 4.2)	Family	Members of this family are probably SAM dependent methyltransferases based on Swiss:P18595 [1]. This family appears to be related to Pfam:PF01596.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.69	0.70	-5.15	16	4779	2012-10-10 17:06:42	2003-04-07 12:59:11	14	11	4534	7	1122	4036	3223	300.00	42	95.42	CHANGED	phtHhoVLLcEslchLp...........l+ssG...lYlDsTlGtGGHoctlLppLsp.t+LhulDpD.pAlttAppcLp.a..ct+hsll+ss..Fsplhphhtct...............hltclDGILhDLGVSS.QLDps-RGFSFpcD.uPLDMRMDpossl.TAtEllNshs.p-LscIhhcYGEE+auKpIA+uIhctRc......ppPhpTTt-Ls-llppshPsht.....++t.......ttHPAs+sFQAlRIhVNcELppLccuLppAhchLsssG.RluVIoFHSLEDRIVKphF+-hsph..p.P.uLPhh.pthp.......hlT+KPIhPSpcElcpNsRSRSAKLRlsEKh	....................................t..pHhsVLLpEsl-.s.Ls...........................................................l+.ss.G..........lYlDuThGtG.GHSchl...L.p.p..L.sp...tG......+......L..............luhDp..D....pA...lttu.....p....p....p......l.p..h...........ssRhshl..+us....Fs.p.l.....t....ph..lpch.......................................................tl..tclDGILhD..L..GVSS.Q......LDp......sER..GFSa..p..p.D..uP.L.DMRM.............D...............t.................s...........p........u.....h....oAt-llNphstp-LsclhhpYG..EE..+...a..u+pIA+t.Il.p.t.R.p......p...p....P.l..po....T.t-Ls-llp.p...u.....h...Pt...tt...................+.c..................t.t.HPA.p.RsF.QAlRItVNsELptlcpu.L.p....p.A.h.c.h.L...............ts........G.G....RluVIoFHSLEDRlVKphh........+........c...t..........u.........p.s............................p.s...P........t......s.......l.......P...hh..........p.p.h...p.sh..........................hphl.s.+...K......s...l.......hPoccElppNsRuRSA+LRlAE+.h..................................................................................	0	409	743	952
+576	PF05060	MGAT2		N-acetylglucosaminyltransferase II (MGAT2)	Moxon SJ	anon	Pfam-B_6001 (release 7.7)	Family	UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [1]. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency,  unrelated to coagulation factors [2].	27.00	27.00	27.40	27.20	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.42	0.70	-5.54	10	200	2012-10-03 05:28:31	2003-04-07 12:59:11	9	4	105	0	131	210	0	274.60	35	75.24	CHANGED	sloLptRshl.shN..p....l.N.sDlaspLsp.........scllIVlQVHNRP...pYL+lLl-SLu+s..+GIscsLLIhSHDhYssElNcllpuIcFCpVhQIFaPYSlplaPssFPGssPsDC.pphcK-cAhcppC.Nuc.PDpYGpYRpu+hsplKHHWWWphNhVWDtL.ccs+sasGalLFlEEDHYlhPDhY+sLphlhshK.phCPsCtslsLGshsh.ops.uh-sthsEVhsahuscHNhGhAhsRslWcKI+sCucpFCoaDDYNWDWTL.tlshsChsp.l+sL..s+uPR..lhHh......G-C.GlHp....sssCpss.ssstplccls+..slpsphaPpslploc+ps.uhpush+sNGGWGDhRDRcLC	.............................................h............hN....thhs..........................phhlVl.VHsR....pYL+hLl.SLtps..psIppsLllhSHDha..-hspll.t.s.lsFC.....V.hQlFaPaShphaPppFPG.sPpDC....t+ptAh.htC.su...PD.aGpaRps.ch.sphKHHWWWKhp........hVapt.....l...c.hp.asGhllFlEEDHalh.Dh.hhhhphh.php......p.CspCt.....hlsLGsh........h..sh.hs.tpps-hhsahSs........a..NhGhAhsRssapplh.t..psppFCpaDDYNWDhoL.hls..t.s...h..............p.....................hh......sh...h.psPR..lhHh........Gc.C....GhHp......ppsCtsp..t..tp.l....pph.p..p.pt.hh..........tl...hl...t.....t.......t........pt.GGWGDh.RD+pLC..........................................................................................................	0	44	65	105
+577	PF02142	MGS	Methylglyoxal_synth; 	MGS-like domain	Bateman A, Mian N	anon	Pfam-B_220 (Release 4.4)	Domain	This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the  allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site [1].	22.90	22.90	23.00	23.10	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.10	0.72	-4.05	164	10875	2009-01-15 18:05:59	2003-04-07 12:59:11	17	65	4646	116	2605	7914	4421	100.00	27	14.06	CHANGED	sllshA+tL.tph.G..acllATuGTu.chLp.cs..Gls.hplsphstps.h.s......................hhchlpptpIp...lVlssh.shptsht.........-shs...lccss.phcIshsT	............................llphAptL.t.ph..G....aclhuTu.GTu....p.hL.....p....c.....s...........Gl.............s..........hpls..p...h..s.t.t..s......h.hsuc................................................................................thhshlpp...t.....c...Is.........lVlssh..hshptsst................-stsl.c.css.phcIsssT...............................	0	852	1659	2184
+578	PF01769	MgtE		Divalent cation transporter	Bateman A	anon	Bateman A	Family	This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)	21.50	21.50	22.00	22.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.48	0.71	-3.88	17	3706	2009-01-15 18:05:59	2003-04-07 12:59:11	11	18	2452	6	1251	2988	1805	127.60	28	31.59	CHANGED	hlPhlhGhsGNhGsphuohlsptLslGplp........tph.plhhcphthshh....luhlhu..shshlhsshh.....sssshlshsVssslhhshhlus...husllslhhc+htlDPs.huuPllTolsDlholhlh.hhlu	.......................................................hhPllsuhGGNs.....GsQsholllR....u.lA.....h....s..p.ls.......................ps.h.h.p.l.l.h+..E.l.s.....l.u......hl........................hGll.hu...........hh..h...h..l..h..s...h..h....h..........................................................h....t.....s.............h..h....l....u.h..s.....l....u.....h....u.h...h...s.s.l....l.husl......hGshl...P.hl..hc.+h.slDP.AlsouPhl.TTlsDlh..Ghhla.hsl....................................	2	418	721	996
+579	PF00993	MHC_II_alpha		Class II histocompatibility antigen, alpha domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1288 (release 3.0)	Domain	\N	20.60	20.60	20.80	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.69	0.72	-4.41	51	3084	2012-10-03 22:02:01	2003-04-07 12:59:11	15	5	277	142	138	2606	0	76.50	45	55.24	CHANGED	DHlutY.hthhQshsssGpaha-FDG-EhFYVDLc+KEsVWpLPpFuchhoF-...sQsuLpsIussKtNLslhhKtsNsTssss	..........................hthhts..s.s....s....G...pasa-FDGDEhFYVDlpKKE.......TV.WpLP.F.u.catoF-.....sQGALsNlAssKtNLslhhKpSspss.................................	0	7	18	38
+580	PF00969	MHC_II_beta		Class II histocompatibility antigen, beta domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_331 (release 3.0)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.49	0.72	-3.99	121	17595	2012-10-03 22:02:01	2003-04-07 12:59:11	14	5	639	123	215	16212	0	69.80	52	67.66	CHANGED	u-CaF.pNGTc+VRalsRahYN+EEa...lRFDSDVGcahAlTELG.....c.sAEhWNSpc-hLEppRAtVDThCRHNYtlhp	..................cChF...N..G..T-RVRalcRYhYNpEEa....lRFDS..D..V..GcahA.s.TELG......cssAEa........WNSQp.-lLEppRAtVDs..hCRHNYtl.........................	0	23	41	74
+581	PF02816	Alpha_kinase	MHCK_EF2_kinase;	Alpha-kinase family	Egelhoff T, Ryazanov A, Bateman A	anon	Egelhoff T	Family	This family is a novel family of eukaryotic protein kinase catalytic  domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases [1,2] and Elongation Factor-2 kinase and a bifunctional ion channel [3]. This family is known as the alpha-kinase family [4]. The structure of the kinase domain [5] revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.	21.30	21.30	21.50	21.50	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.47	0.71	-4.63	63	765	2009-01-15 18:05:59	2003-04-07 12:59:11	13	29	138	16	532	775	15	177.80	24	20.05	CHANGED	FupGsh+tsathh.h....................................ttsphhVsKhhpp.....t.........................p..............................c.hhp-spsphhupphscpFNpph....tts..pp...lp..............ahshh.lhchpsps........................hhhsEta......lpG....capKYNsNt..Gah..............tppsthtphhpAFSHFTYphSptphllsDlQGls...s.......hLTDPtIpot..s.sph....h..u..sshGpcGltpFht.pH.pCsphC	......................................................................................................................................tGthR.shtsh.h....................................p..sp.hlhK.hh...........................................h....................................p.hhhp-..h.p.ph.......hu.phhsptFsph..............t.s.t......p....................................hl..hh..lhp.h.psp..........................hhhlEph......l..pG........ca.h.Kas..sNs..uhh...................................ttssp..h..tphhpAFoHaoYphops....phlVsDlQ......GVs....p........................hlTDPplhshp..tph................h......G..sNhG..pulptFht...pH..pCNphC........................................................	0	305	370	431
+582	PF02854	MIF4G		MIF4G domain	SMART	anon	Alignment kindly provided by SMART	Family	MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G).  Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA [1].	21.00	21.00	21.10	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.33	0.70	-4.92	41	2682	2012-10-11 20:00:58	2003-04-07 12:59:11	14	57	339	22	1754	2678	51	203.50	17	26.69	CHANGED	t+plpulls+ls....pphpphhpplhphhhpp........phhppllphl...hppshtps......shhshhApLsstlspphs....................pFsphllsphhppFpp...................................ppppptsppcthshl+FluELhphph...lspt.hlhp......hltpllpphsc..................pplchlhplLpssGphLp.....................................................ppsppthcphhpphpphhtp................................tphs.clcahlpslhpl+psp	......................................................h...hpshls+ls.....pphpplhpp.l.hph..hhpp..........................thhptllphl....hpts...ht..ps............phs...haApl.ss.t.ltpths..................................................................pht.p..hl...ls.ph..c.pFcp....................................................................t.p.t.c..t..t..s....p.....p.......c.t.hs..l+Flu-L.h..ph.ph.........ls.p........t...lhhp..........hl.t.p.....L.l..pp.hpc.............................................psl.-hlspl...Lpss.....Gt.Lp...............................................................................pp.s.p...t..t.......hc...phhp......phpphhpp...........................................tphs.c...hc.....ahlpshhplpt.........................................................................................................................	1	585	916	1394
+583	PF02815	MIR		MIR domain	Bateman A	anon	Ponting CP (EMBL archive)	Domain	The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function [1].	24.70	24.70	24.90	24.80	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.31	0.71	-4.76	30	1582	2012-10-02 19:42:32	2003-04-07 12:59:11	14	76	302	11	968	1488	5	172.80	24	10.35	CHANGED	GaL+utcslh........htucQpphhsh..........sch-pssc........................WclEs.pps.h...........puutscW..........GshhRl+HlsTG+YLtuc-cp..............................sslscp.chpp-sosYshpsh.ts............................sDt....lplhcpcsssshusspl+stcohhRLpHhtTusaLpupsscl..sthG.tppEpsshpp.....tssh.hhEpc-shs.Ls	......................................................hL+utshhh..........htu.p.Qpp.s.h.sh.......................................s.pt.D.p.ssp....................................Wh.l.c.s.....p..p..s.s.h..............pust.h.ph........................GshhRLpHlsTu.+hLtuccst..........................................sslspp....ptE.so..sa..s.h..psh...ts..............................................................................pDh......hpl.h......phc..s.....p.....p............t..........t...s....p...l..ps.hso.hhRlpHh..s.os...saLpspshpl....sphu.tptEhs...shtp........sph..................................................................................	0	275	441	727
+584	PF04212	MIT		MIT (microtubule interacting and transport) domain	Bateman A	anon	Crosby A, Patel H	Domain	The MIT domain forms an asymmetric three-helix bundle [3] and binds ESCRT-III (endosomal sorting complexes required for transport) substrates [2].	28.30	28.30	28.30	28.30	28.20	28.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-8.98	0.72	-4.09	82	1334	2009-01-15 18:05:59	2003-04-07 12:59:11	13	33	342	20	840	1237	38	69.40	27	14.39	CHANGED	hlppAhchlppAlctDp...tu.......papp.AlphYppulchhhpulphc......p.sspp+ph..l+pKhppYlsRAEpl+phl	........................hpcAhphlppAl.ctDp.......ts.......pacc.AhphY.ppul-hhlp.....ulph-................................p.sspp+ct.....l+pKhppYLsRAEpl+ph............................	0	236	365	592
+585	PF00153	Mito_carr	mito_carr;	Mitochondrial carrier protein	Sonnhammer ELL	anon	Prosite	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.00	0.72	-4.28	188	37736	2009-01-15 18:05:59	2003-04-07 12:59:11	22	243	698	9	25106	35824	767	94.40	21	75.41	CHANGED	pphshhtphhuGuhAGsh.utssstPlDhlKsRlQ................................tts.tpa.puhhcs...........hpplh.+p-G........h.tuLa+GhsssllthsstsulpFs....sY-thKphhhptt	.......................................................................t....h.phh.uG...u.h.u.....G....s....h.....u.......s.........h...........h..........s..........h..P....h........-..........s...l..K..s.....R.hQ.....................................................................................t.tt..tph....p....u......h...h....s.s......................................................h..p.p..l.h...+..p....-......G........................................h...tu....l....a.....+..........G...h.s........s..s.......l..h...p......h......s..s..h........s.......u.....l....has....sY-hh+phh....t............................................................................	0	8054	13500	20193
+586	PF03637	Mob1_phocein		Mob1/phocein family	Bateman A	anon	Pfam-B_1830 (release 7.0)	Family	Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [1]. This family also includes phocein Swiss:Q9QYW3, a rat protein that by yeast two hybrid interacts with striatin [2].	21.90	21.90	23.80	22.00	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-10.99	0.71	-4.60	12	1280	2009-09-10 23:30:30	2003-04-07 12:59:11	12	11	310	3	872	1169	11	157.60	35	62.79	CHANGED	pphspsoLsuu..slpphVpLPpGpDhs-WlAhpsh-FFsplNhlYGolsEaCT.poCPpMousspa-YlWtD..phtK.PsphsAspYlchlhsWhpsplsscplFPo+sul.FPpsFht.lsppIhpRlFRlauHlYh+HFcplhplphEsHlNspFpHFhhFspEFsLlcp+-htsLp	.............................................hhptsltps..slcphVpLPp.G..Dhs-WlAhp...................s.....h........-....Fapp...lN..h.l.a.u..sl.......s........-........h........C....o.p..oC..PhMs...As...s.................p.a................pYhWt-...................pht.+....Ph.ph.........sAs......cYhchlhsWlps.lssc...pl.FP........o.+.......h........u.......h...........s..F......P.....p...s........Fhp......h....sp...pIh..+....RLFRlauHlYhpHa.p...hhp..lt.EsH.....LNopFpHF.hhFhpcasLlstc-htsh.....................................................................	0	273	432	669
+587	PF00994	MoCF_biosynth		Probable molybdopterin binding domain	Bateman A	anon	Pfam-B_1258 (release 3.0)	Domain	This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation [1].	25.10	25.10	25.10	25.20	24.90	25.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.80	0.71	-4.79	149	13076	2009-01-15 18:05:59	2003-04-07 12:59:11	19	66	4239	129	3598	9529	4365	147.50	23	44.05	CHANGED	ullosGsElh...............tGpl..........hDsNu.hlsshlp..p.....hGh.plhths.llsD-.ptlppsl......htt.pp...DlllsoGGsusupcDhohc.............sl.tphhs........hhctlshp.st.................................................shh...hush...stt........s....lh.sLPGsPs...ushsshphhl..............PhLtp	.................................................llosGcElh............................tGph...............hDssu....hl...tphlp...p.............hG...h...p....l...h.....t..hs....l...ls...D.c........p.tl.p..psl..............pps.h.pps.............Dll.lo....oGG.s.....u...s.s...p.......c.......D.hThc........................................sl..t....ph.h...s..p......................h...hp.pluhp...tt.........................................................................hush..h..h.spt........................t.s...lh..sLP.G..sPs.ust.s.s.hpthl....Phl..t......................................................................................................................	0	1154	2293	3059
+588	PF03454	MoeA_C		MoeA C-terminal region (domain IV)	Bateman A	anon	Bateman A	Domain	This domain is found in  proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known [1] and forms an incomplete beta barrel.	20.40	20.40	20.40	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.06	0.72	-4.02	47	4409	2009-01-15 18:05:59	2003-04-07 12:59:11	10	31	3053	40	1367	3598	1140	71.70	25	16.06	CHANGED	puhlspshtsstsRpcalRshlp.....t...uphhspPht...tpsSuhlpolspAsuhlhlspsspt...lpsG-pVpVhhh	..................................uhhsps.h..p.p.s.s..s..RpcFhRutlp................tts.................Gp..h.h..lp.s...s.u........tps..S..u...hls.ohupANshlhls..tspss...........lpsG-hVplh.h..................	0	406	862	1156
+589	PF03453	MoeA_N		MoeA N-terminal region (domain I and II)	Bateman A	anon	Bateman A	Family	This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.	22.50	22.50	22.80	22.90	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.74	0.71	-4.89	52	5148	2009-09-11 13:37:57	2003-04-07 12:59:11	12	42	3304	40	1547	4152	1544	162.50	33	36.85	CHANGED	hhsl-EAhchlhshhtth.......sEpVsltcuh.GRlLA-DlhushslPsFcpSuhDGYAVRupDshsust...................tLpVluclhAGpssp.hplssGpsl+IhTGA.lPpGADAVVhhEpspttss........plplh..ptspsGpNlphtGpDlppGssllppGpplsP...tclulLAuhG	.................................................hslccAlp...h...l...h.s....t..h.p.shs..........sEplsL......t....c......u.....h...G.......RlLA..............c.Dl.hushs.lPsFcsSAMDGYAlR..s.s..D..ht.s.sp.......................................l..V.h.u..c..h..h.A..Gps.................p.....t.......pl...t........s........G...........p........sl.R.I.hTG..A..sl..P......p.........G........u.......D...u.V.Vh.Epspttss..........................tlp.lt.....ps..s...p....s.G.....ps..lR....h............tGEDlp.tGsll.lttGptlss..splulLAohG..................	1	471	975	1318
+591	PF02493	MORN		MORN repeat	Bateman A	anon	Bateman A	Repeat	The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).\	\	A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii [1].  It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton [1].	22.50	5.00	22.50	5.00	22.40	4.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.84	0.73	-6.99	0.73	-3.92	271	23538	2012-10-01 20:24:03	2003-04-07 12:59:11	15	292	1025	32	14186	22201	11255	21.80	32	29.18	CHANGED	YpGpa.ppGhtcGpGhhpassGsp	..............YpGpa..tss..p...t..p...G.p..G.hhhassG...............	0	8471	10144	12192
+592	PF03476	MOSC_N		MOSC N-terminal beta barrel domain	Aravind L, Anantharaman V	anon	Aravind L, Anantharaman V	Domain	This domain is found to the N-terminus of Pfam:PF03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.	21.00	21.00	21.20	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.28	0.71	-10.57	0.71	-4.40	16	1954	2009-01-15 18:05:59	2003-04-07 12:59:11	11	18	1430	1	823	1627	289	117.60	26	29.64	CHANGED	huplssLalaPIKSscuhulpcAp...lsstGhh....tDRtahlls.sc.G............phlTtRpcPpLshlpssh............psshLplsAP.....Ghssltl.lt.....s.ththtssplathshsuhcsG-..........tsuc.WhosaLups	......................plspLalaPlKShp.Glsls.....puh............h.s.s.p.GL............aD...Rt...aM....lsc....ss......G.............................ph...lT...t...R..ph...Pph...s...h..lpssh..................................................ps...sL..t.ls...us....................s.t.s...s.h...hl.t.hs............s.ttp.t..s...s.p..V..a.t.......s....p..h......p..u....h...sss.............................................th.sp.WhSthhu..............................................................................................................................................	0	218	430	658
+593	PF04643	Motilin_assoc	motilin_assoc; 	Motilin/ghrelin-associated peptide	Mifsud W	anon	Pfam-B_5485 (release 7.5)	Family	This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.	19.30	19.30	19.80	19.30	18.30	17.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.78	0.72	-4.48	16	149	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	81	3	37	152	0	54.60	38	51.89	CHANGED	hlDPs...pspt-E-phcI+hsAPh-IGl+loucQhpcattsLE+hLp-lLhpps.pt..scc	........................psttt--p.pIphsAPF-lGl+loutQhppautsLt+hLQ-lLh-ps...................	2	2	4	8
+594	PF04644	Motilin_ghrelin	motilin_ghrelin; 	Motilin/ghrelin	Mifsud W	anon	Pfam-B_5485 (release 7.5)	Family	Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas [1]. This family also includes ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system [2].	21.90	21.90	22.40	23.10	21.20	21.80	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.82	0.72	-7.00	0.72	-4.14	6	118	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	53	1	32	126	0	27.20	59	26.77	CHANGED	VPIFTauElQRh.QEKEppKsp+KSLplQ	.GSSFLSPEHQ+h.QRKEsKK.PsuK.LpPR....	0	2	2	5
+595	PF01398	JAB	Mov34; JAMM;	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Finn RD, Bateman A, Iyer LM, Burroughs AM, Aravind L	anon	Pfam-B_738 (release 3.0)	Family	Members of this family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This family is also known as the MPN domain [3] and PAD-1-like domain [4], JABP1 domain [5] or JAMM domain [7].  These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [7]. Versions of the domain in prokaryotic  cognates of the ubiquitin-modification pathway are predicted to have  a similar role [8]. 	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.47	0.71	-4.34	30	2882	2012-10-10 14:49:21	2003-04-07 12:59:11	16	61	451	19	1880	3177	141	110.70	23	23.48	CHANGED	pssppVhlpslllhphlcHhp+sspt.........................clhGlLlGphps-.........................slcltssFulPhpsspcsspsht.shp...ph.chhcph...............................sc.EplVGWYHopPsh.s..ossDlpspp.apphtss	.........................................................................pVhlpshslhphlc.....H..s.p.p....t..sth..............................cVhG.hL.lGph.s.sc....................................................slclpss..F....s.........h....P...p...........p.....ss..p...........s.s.....s.p.h...s.thp................phhchhcps..........................................sc...pllGW.Y....H....opP......sh...s....os........Dl.pspt.hpth...p..........................................	0	655	1015	1500
+596	PF01853	MOZ_SAS		MOZ/SAS family	Bateman A	anon	Pfam-B_3994 (Release 4.3)	Family	This region of these proteins has been suggested to be homologous to acetyltransferases [1].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.31	0.71	-5.06	15	1290	2012-10-02 22:59:21	2003-04-07 12:59:11	13	26	337	14	784	1296	19	175.50	49	25.71	CHANGED	h++PPGsEIYRcssISlFEVDG+cp.................plYCQNLCLLAKLFLDHKTLYYDV-PFLFYlLTEpDcpG.........sHlVGYFSKEKcSspsYNlACILTLPsYQR+GYG+hLI-FSYELS++EuplGoPEKPLSDLGhLSYRoYWspsllclLhchcs......plTIc-lSphTulsppDIlsTLppLs.hl+YhKspalIsls	..............................................................pHPPGs.EIY......R.......c.............s............s.......l..SlF...E.VDGc..cp.......................+..h..YCQNLCLLAKLFLDHKTLY..YD.......V.-P.....FLFYlhT..c...h...D..p...p...G.................................tH..lVGYFS.K..........E....Kp....S.........p.s.........a.NVuC...ILTLP...........Y.....Q.R+..G..........YG+h.LIcF..........S................Y..L....S...+....h...E.....s..............p..h..........G.oPE...........KPLSDLGhl..S.Y+uYWppsllch.Lh......p..h.p..s................................pl.o.....I.p....clSphTuhp.pDllpTLptLp.hlphhpsp.....h......................................................	0	270	410	629
+597	PF04117	Mpv17_PMP22		Mpv17 / PMP22 family 	Wood V, Finn RD, 	anon	Pfam-B_8493 (release 7.3);	Family	The 22-kDa peroxisomal membrane protein (PMP22) is a major component of peroxisomal membranes. PMP22 seems to be involved in pore forming activity and may contribute to the unspecific permeability of the organelle membrane. PMP22 is synthesised on free cytosolic ribosomes and then directed to the peroxisome membrane by specific targeting information [1]. Mpv17 is a closely related peroxisomal protein. In mouse, the Mpv17 protein is involved in the development of early-onset glomerulosclerosis [2].  More recently a homolog of Mpv17 in S. cerevisiae has been been found to be an integral membrane protein of the inner mitochondrial membrane where it has been proposed to have a role in ethanol metabolism and tolerance during heat-shock [3]. Defects in MPV17 is associated with mitochondrial DNA depletion syndrome (MDDS) and Navajo neurohepatopathy (NNH) [4][5].  MDDS is a clinically heterogeneous group of disorders characterised by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.  Individuals with the hepatocerebral form of mitochondrial DNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.  NNH is an autosomal recessive disease that is prevalent among Navajo children in the South Western states of America.  The major clinical features are hepatopathy, peripheral neuropathy, corneal anesthesia and scarring, acral mutilation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Infantile, childhood, and classic forms of NNH have been described. Mitochondrial DNA depletion was detected in the livers of patients, suggesting a primary defect in mtDNA maintenance [5].	20.30	20.30	20.40	21.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.11	0.72	-4.34	93	1477	2009-01-15 18:05:59	2003-04-07 12:59:11	7	21	327	0	1058	1437	41	66.50	24	28.41	CHANGED	hu.hl....-ups..hppshpclccpahssht.....ssahlWPhsQhlNFthl.PsphRllasshlulh.WssaLShhppp	................................s.hh....pups..h.pphhpcl+ppa.hsshh...............ssa...hl...W...PhsphlNFt.hl...P.h.p...h.Rllasshl....ulh.WssaLShhtt...........	1	361	595	889
+598	PF03587	EMG1	Mra1; Nep1; 	EMG1/NEP1 methyltransferase	Finn RD, Mistry J, Wood V	anon	Pfam-B_3290 (release 7.0)	Family	Members of this family are essential for 40S ribosomal biogenesis.  The structure of EMG1 has revealed that it is a novel member of the superfamily of alpha/beta knot fold methyltransferases [2].	28.20	28.20	28.20	36.20	27.80	28.10	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.25	0.71	-5.03	60	459	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	385	15	316	463	33	199.60	41	81.56	CHANGED	llLtcusLEhl.hp..................csphtLLssscHtshh..c+h...tc...........................s.ccuRPDIlHpsLLtlhDSPLN+.tGhLp.lYIH..TtcshlIpVsPpsRlPRsapRFtGLMtpLLc....+hplhss..utptLlclhc.sslsc.hlss...ssphlh..lSpcGphs...............................................phpchsp...........................................................................................................................pshs.hhlGuhs+Gc.thp.thsp....cp......hSIu.shsLoAtsssu+lssuhE	...................................................lVLppAsLEsh+h.....................t.p.pa.pLLNsDcHtshh...+Kh...s+............................-.ucsRPDIsHQsLLsLLDSPLN+..AG.hLQ.VYI+..Tt+sVLIEVsPpsRIPRTFcRFsGLM.............VQLL+....+hs..I+us.s.u.p.c+LL+V.IK.NPlo.-.aLPs....ss+Kls..lShs.u..thl...............................cs.p.-.hlp.........................................................................................................................tpcsls.lhlGAhA+Gc..hs.scas-.....cp........luIS.sYsLSAuhsCu+hspuhE.................................................................................	0	115	179	261
+599	PF03022	MRJP		Major royal jelly protein	Griffiths-Jones SR	anon	Pfam-B_1099 (release 6.4)	Family	Royal jelly is the food of queen bee larvae, and is responsible for the high reproductive ability of the queen.  Major royal jelly  proteins make up around 90% of larval jelly proteins.   This family also the sequence-related yellow protein of drosophila  which controls pigmentation of the adult cuticle and larval mouth  parts.	19.80	19.80	19.80	20.10	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.62	0.70	-5.20	20	978	2012-10-05 17:30:42	2003-04-07 12:59:11	11	6	294	8	455	1055	14	247.90	22	65.31	CHANGED	sSsa+lslDcCsRLWVLDoGllshsps......hCsPpllsaDLpTcc..ll+phclPpslsp....ssotlsslsVDhhcs....sCttsasYluDttuc...uLIVYshsscpuWRlpsp..thpsDPthsphslsGpsFphpDG......laGhuLushp.s....LYFpPLuSpp.asVsschLpspshtpss....phpphpslGs+u..oQusucuhsp.sGlLFauhlspsuluCWspppshsppNhshls..psscsLpassslKIpc.............pphlalLS....s+hpphhtsclshschNFRIhtsslsclhcsohC	...................................................................................................................ss.phhhD.t.ps+LWllD.sG..h...h.......sh....t..............hs..sspllsh.DLp.o.s.p...........ll+ph.hstshhh.....soh.hssl...s.lDht.s........s.........tsasYlsDs...s...s...............ullVashtssp..u..aR..l...pp.......hhss..s....h......s..s.....h.s.....l.t.........s..........h....p...h....sG..........................h.u.hshs..s...................t...........s........phLYapshuopp.atls.TphLp........stsh..sp...pt..........tthp...l.G.p.+s....sp.ss..u.hhhDt...sGslahs.hppsulhphs..s...p.t........tp.h.th.lh...pssp....h.assshthst..........................pt.lahhs........sph................t......................................................................................................................................................................................	0	144	221	388
+600	PF04707	PRELI	MSF1; 	PRELI-like family	Mifsud W	anon	Pfam-B_5792 (release 7.5)	Family	This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.	20.40	20.40	21.70	20.40	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.85	0.71	-4.66	16	922	2009-01-15 18:05:59	2003-04-07 12:59:11	9	17	286	0	571	815	0	145.80	29	50.50	CHANGED	-pVssAahp+YPN.PhsspllusDVlcRc.lss.pGp.LhT.cRllphph.....shPcalc+..llGs..sp..sahhEpSslD.pc+ohslcopNloasshlpVcEpspYpsHs-Ns.shThhcQcApls..lhs.hhuhsstlEchuhppaspN.ssKG+cuhEallpp.lptp	..............-.VhtAhhp+.Y....P....N....Ph..s........spVlusDl..lpRp.lss...sGt.....Lto.cRllp.pp............thP....phlcp................l.huh.............sp..s.alhEcShl....Dsp.......p+....shp.hpo......pN..l.oa.ss.....h...l......p......VpEpssYp...s....ps.....c....s......s...s.....hTh.....hp.Q...pA.ls.......hh.u...h...hs.h.p.ptlEphhhppappN...spKGppshEhhlpp.....p.................................................	1	155	247	414
+601	PF00635	Motile_Sperm	MSP_domain; 	MSP (Major sperm protein) domain	Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.	22.80	22.80	22.80	22.80	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.16	0.72	-4.41	63	1788	2009-01-15 18:05:59	2003-04-07 12:59:11	21	69	335	35	1207	1567	9	102.30	22	37.32	CHANGED	hlplpP.sptlhhss.h.........ssspl..plpNsosp.pluFKlKoTssppYpVcPshGllpPspshplpl..hhps.p...ss..p.......pDKhhlphshs.tstssstpshpphhppsps	..................................h.l.lpP.t.t.lh.Ftt.h.........tp...hpptl..pl..p.....N.......s....o..sp...t.lsF..K........l........K..TT...sP..c....c..Y..p.V....c....Ps.s.G.l.l...........cP.tps.s.p.l.s...........l.........hh.p.s.t.....st.p................pD+Fhlpss.s..tsts.t......ht........s..............................................................	0	442	671	1055
+602	PF03820	Mtc		Tricarboxylate carrier	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	19.10	19.10	19.50	19.40	18.30	17.70	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-11.91	0.70	-5.77	9	716	2009-09-11 12:47:20	2003-04-07 12:59:11	12	12	283	0	439	638	7	268.20	38	91.85	CHANGED	aD.STahGRs+HFhphTsPhsLlsopppLpcu+pIVpcY+pGphsssh.Ts--lW+AKplhDSsaHPDTGEphhhhGRMSuQVPhNhllTGGML..shYpsssuVVFWQWhNQSFNAlVNYoNRSuss.hospQLhsuYsuATouAhssALGLNphl...KphsP....LluRLVPFAAVusANslNIPhMRppElp...pGIsVhD-sGpplGpSptAAhhuIupVslSRlhMAhPsMslsPllhppLpKpsahpppPthts....PlQslLsGhsLhhusPluCAlFPQ+ssIpls...pLEPclppplc+..pssPscpVYaNKGL	........................................................aD.sTahGRhpHahplsDP............psl...hho...p...ppLcpA+pl.l..ppa.....+.......t........G........h......s......h......pppp...LWpA+hlh-SshH.P....DTGEhhhh..hRMSs.........lPhs.h.h.ls....u.s...ML..t.....h......................ps....ss.usl.FW.QWhNQSaNAhVNYsN.....Rsu...s...s....P.....h....o..........spp.......l.htu...Y..hsAss.....u.u...susA.....l.G...L....s.ths..........+phsP..........l..lsRhV...P..F.sAV...AuAsslNlshMRtp..Elp................pGIs.V.................h...................D.........c......s...G...........p..............p..............l....G...p.SppA.A.thulspsslSR.lhhshPsM..hl.sPllhph.L...p.+.....t.t.....h...h....p..p...h...s...h.h.t.h...................P.l..phh...ls.....hhs..hh.....hshPhuhu..l..F..PQ..p.......splpss.............pL...E...s..-hptth.t.t.............t.hlhaN+Gl....................................	1	137	197	330
+603	PF00249	Myb_DNA-binding	myb_DNA-binding; 	Myb-like DNA-binding domain	Bateman A, Finn RD	anon	Prosite	Domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.23	0.72	-3.90	194	12500	2012-10-04 14:01:11	2003-04-07 12:59:11	26	179	730	34	6476	17506	196	47.00	26	14.31	CHANGED	+ssWTt-E-phlhphlpphGsp....................WptIupphs.........sRospps+p+Wpshh	............................................+ttWTt-.Ecphll.p..h..l.....p..p...hGpp...........................................................Wp.pI.u...p..p.hs...................sRT.s..pps+p+.apph................................	0	1753	4075	5391
+604	PF02736	Myosin_N		Myosin N-terminal SH3-like domain	Bateman A	anon	Pfam-B_110 (Release 5.5)	Domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	20.70	17.00	20.70	17.30	20.60	16.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.82	0.72	-4.28	41	1520	2009-09-14 13:17:30	2003-04-07 12:59:11	14	67	230	150	754	1364	7	42.00	35	2.67	CHANGED	KptsWV.sDscE..ualpucIp..sppG-pVoVpsts...Gc..pholKcDc	..........KptVWV.sDs+c..ualcu.plp...pc..cGsc.Vs.Vcsts...G+............plsVccDp..................	0	141	253	484
+605	PF00784	MyTH4		MyTH4 domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.	19.20	19.20	20.20	19.20	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.18	0.71	-4.15	11	1375	2009-09-11 15:02:25	2003-04-07 12:59:11	12	160	222	5	806	1210	7	107.20	31	9.90	CHANGED	ppsh-llppIlppulpp.sLRDElYCQlhKQhscNPs..ppStt+GWcLlhhssusFsPScplhtaLp.pFlpsp.t.......htshAhhs.cpL++ohpsG..sR+hsPuhhElpAhp	.................................p...thhp.ll..phsh.pp....t.L...R..DElYsQlhKQho........p.N.ss.................ppS..t..tR..GWpLLsl.ssu.hFs.P.S.p.p..hht..........aLp.pFlppp..h...t......................................................................t....t....h........Ahh.C..c.pLp...+.o.hp..pG........sR..p.......sPohhElpAh....................................................	1	262	339	583
+606	PF03485	Arg_tRNA_synt_N	N-Arg; 	Arginyl tRNA synthetase N terminal domain	Bateman A	anon	Bateman A	Domain	This domain is found at the amino terminus of Arginyl  tRNA synthetase, also called additional domain 1 (Add-1). It is about 140 residues long and it has been suggested that this domain will be involved in tRNA recognition [1].	21.30	21.30	21.30	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.78	0.72	-3.44	174	5094	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	4796	10	1267	3829	1849	86.10	28	15.38	CHANGED	pplpptlppulpph................th...hlc.h..s.....pp.paGDausNhAhtLAKth+p.......sPpplApplsp...plpts....th......lp..cl-luGP....GFINhhL	.....................................hpphltpslpph................hs.tts.ph..hlc..p....s.......cpspaG.D.....ausNhA..hsLAKhh+p.............sP+plApplsp......pLsts.................sh.......hp.....c.....lEl.AGP...G.FINhhL..................	0	428	821	1065
+607	PF01699	Na_Ca_ex	Na_Ca_Ex; 	Sodium/calcium exchanger protein	Bashton M, Bateman A	anon	Pfam-B_1680 (release 4.1)	Family	This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [2]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [2].  In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [1] see Swiss:Q01728, Swiss:P48768 and Swiss:P70549 respectively.	24.90	24.90	25.00	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.57	0.71	-4.58	111	11392	2009-01-15 18:05:59	2003-04-07 12:59:11	19	59	3066	4	4750	9872	2859	136.70	20	50.60	CHANGED	lhlhhhuchlssshs.slu.p..................hhs....lsstllGlsllAhusuhPEhhsulhushp...............s.......psslulusllGSslhslhlslGlsslhssh...................................htstshthsh.shhhhshhhlhhhhh......................ttplshhpullhlhhYhhalhhh	.................................................h.hlhhhuph.hstshp.tlu.p...................................hhs..............l.sphlh.....Glsll..Ah..G.oS...hP........E.l.h....s.......u.lh..u.s.hp..................................................s..............psclu...lus.......ll....GS....s.l.h......N...l...h.l....l...l.u..ls..s.llsshh....................................................hps.t.s..h..p.h..s...h......sh..h.h..h.s..h.l.hh..h.lhhh.............................................tst.p...l...s.h....h....p....G..h.l...h.l.h..hahhalhh.h.........................................................................	0	1381	2625	3903
+608	PF00999	Na_H_Exchanger		Sodium/hydrogen exchanger family	Finn RD, Bateman A	anon	Pfam-B_312 (release 3.0)	Family	Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus.\	The transmembrane regions M3-M12 share identity with other members of the family.  The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions.  The cytoplasmic region has little similarity throughout the family.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.36	0.70	-5.93	80	17250	2012-10-02 17:06:44	2003-04-07 12:59:11	16	72	4700	5	5319	13718	2497	371.20	18	66.67	CHANGED	hllllh.uhlssh..h.hp+lp...lPs........lluhllsGlllGshshs...........h...............................hhphluplGlshllFhsGlchshpp.lppshts..............slhhulluhlhshhh............Ghhht.h...........h...hshhtulhhGshl.osoussllhtll......-pttlspphuplllutullsDhssllllslhhshh.........shhhshh...............hhhhhhhhhhhshlhhthlhshlhphhpch.......tstplhhhhslhhshhs..shhuchl.GlssllGuahsGlslu...........ptthppp..lppp....lpsht....shhhslFFlhlGlpls.................h...........hthhhhllhhllhlhl.s+hlsshhhtthh...............t.hshppsh...hlu.hshh.+Gthslslsthuhpt......tlhsp..............ph.hshhlhssllosl.....lssh.......lht	........................................................................................................................h..hhhhh.s.h.lhsh.........l..hp+lt........lP...........h..ls...hl......l..s..G...l....l.......l......G....s...h..s..hs................h..ht.s...........................................................................hp.h.h..s...p...lu.l..s.hl...l...F...h............s.G................h.c.h.....s...h......p..p....l..h..p..h..ht...........................................hh..hhu...h.h..t.lhl.sshh.....................................huhhhhh.........................................h..hs.h.s.h.h.t..u..l.h...l.G...s.....hl...u.s......o.....s.s.......ss.l.ht....ll.......................cpt....t....h....s.p.p...h...s...p....h...lh...........utul.....h.s.........Dhsu.ll.h.....h..sh.hhshh.....................tstth.s.h.h..............................................................t.h.h.h..t.h....h.....h..h....h.h.h.....h....l....l....h..t..h...l....h...s.....h....l.....h.t..h.......hhph...............................tsp...ph.h...h...h.h..s..l.h....h..shhs........hh...............h..s........p......h.......l........s............h............S...........s.......h..l..u..s...........h...hu.G.lh..lu.....................ptth.pp..p.......hppp..........................................hp..shh..............hlh.slh.F...l.hl..Gh.tls.......................thl.....................hth.h..h.h....l.l.h....h....h.h........h.l...h..l....s+h...l...ss..h...h..h.h.hhh..................................................................t..hs.h.p..p.t.h.........hhu...hs...hs....pG....t...hu.h..s......l....s....h....h..s...tt.......................th..h.s..t.....................................ph.....h...s...h....h....h....h....s...l....l..l.ohh.h....s..h..h...hh...............................................................................	0	1593	3099	4353
+609	PF02690	Na_Pi_cotrans		Na+/Pi-cotransporter	Bashton M, Bateman A, Haft D	anon	Pfam-B_509 (release 5.5)	Family	This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of  which are also Na+/Pi-cotransporters.  In the kidney the type II renal  Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the  proximal tubule [1].	28.60	28.60	29.20	28.70	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.63	0.71	-4.47	184	5785	2009-09-10 16:47:48	2003-04-07 12:59:11	10	11	2359	0	1241	3956	693	134.10	26	49.88	CHANGED	LhLhG.hphhssGlppssG.sp..l+plLt..phTs...s........htull....sGhhsTullQSSSssol...lsluFVuuGllsltpulullhGANlGTTlTuhllu.............hcl.uthu.hhlhlGsllhhh..pppphpthGthlhGlullFhulphhppu	..............................hhhhu.hphhspuh.p...hts..sp...h.c.p.l.ht....phss.....s.............hhull.......sGhhlTsl.........lQSSoAsss..............lssuhs..u.......s.......G...............l.l.......s.......lptAlsllhGANlGTslTAhlhu..................................................hcl...u.hh...ph.h.h..hl..Gsl.l.hhh....................................h..........................................................................................	0	429	745	997
+610	PF02445	NadA		Quinolinate synthetase A protein	Bateman A	anon	Pfam-B_1915 (release 5.4)	Family	Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid [2]. This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein".	19.00	19.00	20.70	20.60	18.60	17.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.89	0.70	-5.61	144	2787	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	2689	2	795	2280	2221	307.90	41	89.62	CHANGED	hpcIpcLKc-..+sAlILAH.YQpsEl.Q-lADhsG....DSLpLuctAsp.scA-sIVFCGV+FMAEoAKIL.s.P-Kp.........VLlP-h.pAGCshA-hhss-pl....pph+cpa...Ps......tsVVsYlNooAclKA....tuDlsCTSSNAlclVpp.l....sp..cc.IlFhPDcpLGpal..............................tcps.s+cl................................llWs...GhC.VHppassc.clpph+ppa.PsApllsHPEC...s.cVlchAD........hlGSTutllcasppsssp.c.alluTEhGllpcLpc..cs....Ps.Kpahshs.........s.pshCspM+hhTLcclhpsLc......shp.................sc.lpls..c-ltpcAppul-RMLcl	............t.pcIccLh+c..+sAVllAHa.YpcsEI.QplA-hsG..................DSLphA+h.u....sc....psA...ssllhsGV+FMu.ET.A.K.I.L.....o....P-...Kp......................VL...hP.....s.l.p.A.....sCSLs.usss.-ph........................ptap-ta.............P-...............tsVVsYsNTSAAVKA.....cuD.....hssTSSsAl.c.llcp....l.........sp......s...ccIlasPDcaLGpal...................................................................................pcpT..stch...................................lhWp...GtChVH-c.F.psp.plpch+.pp.a....P-.At.llVHPEs.............stsVl.phAD...........hlGSTotlIcts............p....sh...........ss...........p....c.......hIVuT-tGlha+hpp....ts....P.-...Kp..h..lt.ss.......................................................s..sshCPaMthssLpplhps...Lc.....p..tt.......................pElp.VD..ppltppAhhsLpRML-.h................................................................................................	0	274	536	683
+611	PF03822	NAF		NAF domain	Griffiths-Jones SR	anon	PROSITE	Domain	\N	25.00	25.00	26.00	26.00	21.80	24.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.19	0.72	-4.26	71	764	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	57	2	323	696	0	60.30	43	14.83	CHANGED	pPss..lNAF-lI.ShSpGhDLSuLFtccpct....c..sRFsSppsAsslluKlEplAc..shs.apV..+K	..................PtshNAF-lI.S.hSpGhsLSuLF-ccp.p...................pcc......sRFsS.pp...PAspIluKlE-sAc...shu.apVpK.............	0	37	177	261
+612	PF05089	NAGLU		Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain	Moxon SJ, Bateman A	anon	Pfam-B_6295 (release 7.7)	Domain	Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2]. The structure shows that the enzyme is composed of three domains.  This central domain has a tim barrel fold [3].	23.40	23.40	23.70	23.80	20.50	22.50	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.06	0.70	-5.69	30	411	2012-10-03 05:44:19	2003-04-07 12:59:11	7	31	267	5	179	405	16	304.40	38	38.80	CHANGED	RYahNsCTaSYohsaWsWpcWE+cIDWMALpGINhsLAhsGQEulWpcVapchGlocpElcsahoGPAahAWpRMuNlcG.WGGPLspsWhcppttLQ++IlsRMRpLGMpPVLPuFuGaVPpshpchh.PpAplschusWsu......assshaL-P.....pDPlFscluptFlcc.pchY.G.sschYssDsFNEhsPsss...ss............................phLussupulacuhppsDPcAVWl.hQGWhF..p..hWpssthcAhLsuVP.....ps+.hlVLDLauEphP.hWpp..........ocuahGpPaIWChLpNFGGshslaGslptlsssh.pAttps..ssslhGsGhoPEGlcpNslhYELhhEhuWpps.	.......................RYahNhCThuYohsaWsWpcWE+cIDWMALpGlNhsLAhsGpEslWpclhp..c.hGh.opp-l.ppahsGPAahsWtpMuNlpu..W......u..G.....P.Lsp.....sWhppphtL.Q++IlpRM+phGMpPVLPuFuGhVPpsh...............p......c...hh..P..p......splhp..s..pWss........as...ps...h....hLpP..........pD.s...hFtplu.phFhcc.pcha.G....ssphYshDsFpEhtssss......ts.................................lsphupslhpuh.pts.cscAlWl.hQuW.a........W.ps.s.hpuhLpu.V.s.........p.sc.hllLDLa..uEttP.h......app...........ppsahGpPaIaChLpNFGGshshhGphptlspt.......hpAh......tps....sssh........hGhGhs.EGlppN.lhY-Lhh-huWppt.s...................................................	0	64	108	149
+613	PF02365	NAM		No apical meristem (NAM) protein	Bashton M, Bateman A	anon	Pfam-B_530 (release 5.2)	Family	This is a family of no apical meristem (NAM) proteins these are plant development proteins.  Mutations in NAM result in the failure to develop a shoot apical meristem in petunia embryos [2].  NAM is indicated as having a role in determining positions of meristems and primordial [2]. One member of this family NAP (NAC-like, activated by AP3/PI) is encoded by the target genes of the AP3/PI transcriptional activators and functions in the transition between growth by cell division and cell expansion in stamens and petals [1].	21.20	21.20	21.20	21.50	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.25	0.71	-3.95	133	2410	2009-01-15 18:05:59	2003-04-07 12:59:11	10	26	114	15	1319	2332	1	125.10	42	37.77	CHANGED	LPPGFRF+PTDEELlsaYLcpK.ltup............hsh..p................s.Is-l.D....lhch.-P.W-L..P...h.........................hh.s.......tpp..EW..Y....FFs.+-+KYs....s.Gt.........RsNR.u......................Tt.....uGY..WK.ATGp..D+tlhs.............ssth............lGhKKTLVFY....p.......G.+uPcGp....+TsWlMHE.YRL.s	..................................lPPGFR..F.+PT.DEELlhaYLpcK..ltspt..........hsh...p.................h..I.s....-l..D.....lh...+.h...-....P.W-L..P..t...................................thth....scp....EW......YF.Fs..+..-..+...K..Ys.........s...Gs........R.s..NR...u.........................................ss........uGa...W.K...A..T.Gp....D+s..lhs................ssph...................lGhK.K.sLVFY..............p...G..+....u..P...+......G..p........KTsWlMHEYRL.s....................................................................	0	160	722	1039
+614	PF04095	NAPRTase		Nicotinate phosphoribosyltransferase (NAPRTase) family	Wood V, Finn RD, Bateman A	anon	Pfam-B_5038 (release 7.3) & Pfam-B_5422 (Release 7.5)	Family	Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in  the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase Pfam:PF01729.	19.90	19.90	20.10	20.00	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.66	0.70	-5.09	19	4673	2012-10-03 05:58:16	2003-04-07 12:59:11	11	6	3929	55	1191	3401	285	219.70	27	50.59	CHANGED	aplpDFGsRtt.Shcstthssp...........sthstFhGTuslhh.............stthul.shtppshphhtscpplss...hlpphpp.........suh-hWhttht...hG.sLpDhlshcuhhtths...........hslR.DSGDPhp.................hh-clht+atsh.shcsh.....phtllauDGlshcphhplhcthcs.th...sluFGlGosLhpclsp.h.t....ssslsIshKhhpsptpPlsclS.csstKuh.................hts.....hthl+psFpsst	.........................................................................................lh-FGoRRt.phcstthssp...t..........................uh.h..u.u.hsuTSNlhs......................ucta...u..lsshGTtAHsa........h.......t.....s.....a.....t.....p.h..s.....s....................h.p.s.htp.......................................tsh..sh..hhs...pa.......slt....ulssslps...st.h.t.ph...............................................hhGlRhDS.....GD.sh........................................................................hucc....stphh...-c...h....t.......sh...............................ptpllhSssL.D...pp.l..h..pLhtphsp...............................ssaGlGT.....pLhs.....s.........h.......s..........p..............................h.ss..l.................p..h..s..h......p.h....h.................................s......h.hch.o..pp.tp........................................................................p......................................................................................	0	381	694	967
+615	PF04970	LRAT	NC;	Lecithin retinol acyltransferase	Finn RD	anon	Pfam-B_3758 (release 7.0)	Domain	The full-length members of this family, eg Swiss:P53816, are representatives of a novel class II tumour-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localisation, but not necessary for the enzyme activity [1].  H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyses the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester [2].	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.81	0.71	-4.17	32	808	2012-10-10 12:56:15	2003-04-07 12:59:11	8	10	297	3	418	739	44	120.20	26	54.98	CHANGED	h.......p.GDllpl.R.......hYpHaGIYlGDspVlHhs.......Ps..............t..ssstt...........hhushtptuhVchs.sL-shstGsshhlssh........t.......tptpshss-cllpRAct.LlG....ph.sYsLlhsNCEHFVsaC+aGhsh	......................................................hh.....t.p.GDhl....h...R...........hY.pHaulY..l......G.....c....s.....h......Vl..Hhs...................................................................................hhu..hh..t...p.p.u...hVcts..pLpsh....s..t.u...s.p...h...plssh................................t.................phps...hsscpllp..R.App..hlG..........ph...p.....YsLhts....NCEHFsshs+hGh..t........................................	0	78	152	260
+616	PF04904	NCD1		NAB conserved region 1 (NCD1)	Kerrison ND	anon	Pfam-B_6188 (release 7.6)	Family	Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors [1]. This region consists of the N-terminal NAB conserved region 1, which  interacts with the EGR1 inhibitory domain (R1) [1].  It may also mediate multimerisation.	25.00	25.00	40.20	39.70	21.60	20.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.57	0.72	-4.24	4	175	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	92	0	89	144	0	79.10	79	17.49	CHANGED	hspPoTLuELQLY+VLQRANLLsYYDsFIppGGDDlQQLCEAsEEEFLEIMALVGMAoKPLHVRRhQKALpEWsTsPshFpp	........uLPRTLGELQLYRlLQRANLLSYY-sFIQQ...GGDDVQQLCEAGE..EEFLEIMALVGMAoKPLHVRRLQKALR-WsTNPGLFsQ.....	1	21	29	56
+617	PF04905	NCD2		NAB conserved region 2 (NCD2)	Kerrison ND	anon	Pfam-B_6188 (release 7.6)	Family	Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors [1]. This family consists of NAB conserved region 2, near the C-terminus of the protein.  It is necessary for transcriptional repression by the Nab  proteins [1].  It is also required for transcription activation by Nab  proteins at Nab-activated promoters [2].	25.00	25.00	29.80	25.60	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.02	0.71	-4.45	5	176	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	91	1	93	153	0	152.80	49	30.99	CHANGED	scppsSppshS.PusLGSPtSs...tlusp-ouuss....ssLssstltplsEsuERhu+oLP+uDhuEVscLLKsNKKLAKplGHIlEMS-sDP++EEEIRKYSAIYGRFDSKRR-GKpLTLHE........................LTVNEAAAQLCh+DsALLTRRDELFuLARQVuREsTYpYoh+oSRL+	..........................................................s..tptup.shS..Pus.hGsPtus...............ttsu.........-tL-sthst.VsE.sVERhhtohP+.uDhsElppLLKhNKKLA+..plGHIFEMsDsDspKEEEIRKYSuIYGRFDSKR+-GKpLTLHE........................LTlNEAAAQlCh+Dss..LLTR.RcELFuLARQ.......luREsoYhhoh+so+...............	0	26	34	60
+618	PF03096	Ndr		Ndr family	Mifsud W	anon	Pfam-B_2481 (release 6.4)	Family	This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted [1]. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular  differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21 Swiss:O23969. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases Pfam:PF00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.65	0.70	-5.93	10	725	2012-10-03 11:45:05	2003-04-07 12:59:11	9	5	129	8	272	2897	1291	225.90	42	76.06	CHANGED	EHplcTsaGulpVoVpGs.ct..p+PsllTYHDlGLNHcSCFpsLFsp.EsMsEltc+FslhHVssPGpEpGAsshspsa.aPSl-sLA-plssVLsaFplcoVIGhGsGAGAYILsRFAlpaP-RVpGLVLlNssssAsGWh-WstsKlss..h...GhosslhDhllsHhFu+Etpps....ss-...lVppYRphlscshN.sNLphalpAassR+DLshctssht..........CsslLlVGDpSPah-sVlcsso+LDsppoolLKlscsGGhVpt-QPsKlscuhchFLpGhGahs	...............................................................................p.lcTsaG...lp.V.slh..Gs.c............+PsllTYH.DlG.LN.apoCFp.shF....p.........h..-sM.p.-....lh.pp...F...slhHV....-...A...P..G..p.....p.....G....A.s..s....h..P.....s......a........a...P...o.h..-p..L..A-..l.ssV.Lpa.h...s...h...p...s..l...I.G.h.Gl.GA.G..A.Yl.....L.s.+.F..A...........l..t.a....P.c....h....V.GL..lL.......l.......N............h.....s.......s.........s.....u........t........u......W........h...-......W.........h.............h.....p.........K....l.............................................................G......h...s.....p..s....l........-...h..l........h....t....H....h......F.u...p.p...htt..............p.-.......ll..p..t...a...R...t.....l...t..p....t.......s................N..l....t..h..a....h...p.....u...a..........p........p.....R........p....D....L..p.....p..h...h.h......................s..shll..s...G..s...p....u...P...h.......p..s..s...............l.....c....h....s..s..+...L......s...........p...p.........o......s.h.....l.c..h.t.c.....s.su.....s...pQPtp...lspuhchFlp.GhGhh......................................................................................................................................................................	0	74	119	189
+619	PF03102	NeuB		NeuB family	Mifsud W	anon	Pfam-B_2572 (release 6.4)	Family	NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This reaction has only been observed in prokaryotes; eukaryotes synthesise the 9-phosphate form, Neu5Ac-9-P, and utilise ManNAc-6-P instead of ManNAc. Such eukaryotic enzymes are not present in this family [1]. This family also contains SpsE spore coat polysaccharide biosynthesis proteins.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-5.23	158	1576	2012-10-03 05:58:16	2003-04-07 12:59:11	9	19	1121	8	447	2406	3908	236.80	36	67.28	CHANGED	lI-sAtc.AGADAlKFQTaps-slsspt..sppsp.....athpp....hssp.o.h-hhcchc.hsh-.appLhcascptGItahSTPFDhpul-hL.pplssstaKIuSuEloshPLlctlAp...psKP.....lIlSTGMuolsEIcpAlssl...........................tpssspplsLLHCsosYPsPh--...lNLpslpsLpptF...s..l.l.GhSDHTh...GhtsslAAlALGAsl..........IEKHFTLD+sh....tGPDHthS..L-PpEhcphVpslRplcpAL.Gsshc	................................................................hlcsAtc.uGADulKaQTaps-shhspt.......s.ps...........a.hpss.......hssp..ohh-h.hcch..c.hsh-.atpL..hcas.c.chGlhhhSoPF.Dhpul-hL..pph......s..sshaKIuSsE...ls.....shP.hlctlAp.....psKP..........lIlSTG.M.u.o.h.p.EI.cpAlphh.....................................pp.t.t..s.psls.l....L....H.......C..s....osY.P.s.s...h..-.-........s.N......LpsltsLpc....tF...s........l.........l........Gh..S....D..Hoh.....G.....h.......t.....s.....sl.....u.....A.....V.A.LG...Ap..l...........I..EKHFTLD+sh....tG.sDp.thS.l-PpEhcphlp.slRpsppAL.Gss........................................................................................................	0	154	297	373
+620	PF02931	Neur_chan_LBD		Neurotransmitter-gated ion-channel ligand binding domain	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family is the extracellular ligand binding domain of these ion channels [1].  This domain forms a pentameric arrangement in the known structure.	25.80	25.80	25.90	25.80	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.64	0.70	-5.19	92	6005	2009-12-16 13:50:00	2003-04-07 12:59:11	18	90	267	651	3245	5129	71	186.70	25	43.27	CHANGED	pp+LlccLhps....YsptlRPs.....pssp.....s.lsVplsltlpplhslsEhsp.hosslalpppWpD.+LpWsstp....asslpplplssc......plWhPDlhLhN.....sssspapso.hpsplhlp.........sGpVhahsss.hhcusC.lclphFPFDpQsCslpFuS............asYss.......pclslphtp............................pphclssFh.supWslhph...shpttp.hs.hsp.........l.aplhl+R+s	......................................................................hhppLhtt......Y.s...t...h...hRPs......................st.........................sh...V....phsl.........lt..p..lhs..l................s.-hs........................hsh..............s......l.ahp...............p....p..............W.......p..........D.......+...Lp..a.s............p................s.s.h...p.t..l...p...l..ssp......................plWhP..Dhhhh..N............p..........t...........s.........t....a.....p....h.....s.............p...p.............h....lhl..h............................sG..p....l.....h......a.....s..............................h.....hh..p...............u.sC....h.c.........l.ph..............FPh.D..t...Q..s......CslphtS........................................a.s..Y.st............pc...lth.h.htp.....................................................pt.h..pl.s..p..a.h......p.......sp.hth....ht....................h...........hs..thst...............h..thhlcRp..............................................................................................	0	1010	1272	2385
+621	PF01436	NHL		NHL repeat	Bateman A	anon	[1]	Repeat	The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies.  It is about 40 residues long and resembles the WD repeat Pfam:PF00400.  The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localised to the repeats [2]. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats [3].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.93	0.73	-7.24	0.73	-3.73	108	7067	2012-10-05 17:30:42	2003-04-07 12:59:11	16	402	688	32	4354	6356	1348	27.90	34	11.21	CHANGED	hstPpulsls..sssplhVsD..ppspplhha	........hptPpGlAls...ssGp..laVuD........psNpRlphh..............	0	2548	3068	3732
+622	PF03031	NIF		NLI interacting factor-like phosphatase	Griffiths-Jones SR	anon	Pfam-B_1405 (release 6.4)	Family	This family contains a number of NLI interacting factor isoforms (eg. Swiss:Q9PTJ8) and also an N-terminal regions of RNA polymerase II CTC phosphatase (Swiss:Q9Y5BO) and FCP1 serine phosphatase (Swiss:Q9PT70). This region has been identified as the minimal phosphatase domain [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.36	0.71	-4.57	120	2877	2012-10-03 04:19:28	2003-04-07 12:59:11	13	63	441	30	1934	3360	347	157.00	26	34.52	CHANGED	hsLVLDLDET...LlHsp.t...................hh..............................hphhlth......RPhlccF...Lp.pl.uph..aElllaTuut..ppYAptllchlD.......s.....pphh...pppl....aR........c...pCh.......hps..h.l..K...DLshl.....................sR.s..........LspllllDssspsahhp.spNul.Ips......ahss.......ps.Dp.........pLhp...LhshL.ctlt..ph.pDVR	................................................................................................sLVLDLDcT..LlHsphp...........................................................................................hth.hlhh.............R..Pt..l..c...pF....Lp..ph...uph..........aE.ll..l.aTu.u.h..............p.t...Y.Ap.......slh.c.h.L.D.....................................s..........pphh.........ptp.l.............hR...................................................c...psh...............................hpu...ph..h.........K...................-L.s.hl.....................................................................sp..s.............h..sps.ll...lDss.s.t.s.ah.hp....s......p...N..u.l..lps.................ahss........................p.Dp.........tLhp......lh.hl.p.l................................................................................................	0	769	1211	1633
+623	PF04923	Ninjurin		Ninjurin 	Finn RD	anon	Pfam-B_5824 (release 7.6)	Family	Ninjurin (nerve injury-induced protein) is involved in nerve regeneration and in the formation and function in some tissues [1].	20.70	20.70	20.80	20.70	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.29	0.72	-4.30	50	257	2009-11-15 17:29:03	2003-04-07 12:59:11	7	5	73	0	176	264	1	98.90	39	59.48	CHANGED	shNpYss+KolApuhhDlALLoA..NAsQ.....L+hllphspp...tthYhhh.lsLlslSllLQlllullllhhup...hslppt..................................ppppp.hpphNshsshh.............................lhllsllNllIouFs	............shNpYusKKolApuMlDlALLhA..NAsQ...........L+hllp.Gsp...htaYhsh.lsLIolSllLQlhlGlLLlhlup......hslpp...................................tcpt+.hshlNNhsshhlFllsllNlhIouFs........................................	0	55	71	132
+624	PF02613	Nitrate_red_del		Nitrate reductase delta subunit	Bashton M, Bateman A	anon	COG2180	Family	This family is the delta subunit of the nitrate reductase enzyme, The delta subunit is not part of the nitrate reductase enzyme but is most likely needed for assembly of the multi-subunit enzyme complex [1].  In the absence of the delta subunit the core alpha beta enzyme complex is unstable [1].  The delta subunit is essential for enzyme activity in vivo and in vitro [1].  The nitrate reductase enzyme, EC:1.7.99.4 catalyse the conversion of nitrite to nitrate via the reduction of an acceptor.\	\	   The nitrate reductase enzyme is composed of three subunits [1].\	   Nitrate is the most widely used alternative electron acceptor after oxygen [1]. This family also now contains the family TorD, a family of cytoplasmic chaperone proteins; like many prokaryotic molybdoenzymes, the TMAO reductase (TorA) of Escherichia coli requires the insertion of a bis(molybdopterin guanine dinucleotide) molybdenum (bis(MGD)Mo) cofactor in its catalytic site to be active and translocated to the periplasm. The TorD chaperone increases apoTorA activation up to four-fold, allowing maturation of most of the apoprotein.   Therefore TorD is involved in the first step of TorA maturation to make it competent to receive the cofactor [2].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.73	0.71	-4.34	270	4923	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	2034	17	709	2437	138	149.30	21	69.62	CHANGED	shhshht.h.shst..........................tpt....ltthhp..thtppshtplpt-YspLF........hsPasShYLs.......sc.......hhGpshhclpphhpptGlphss....pEssDHlulhLEhhuhL..................sphttthphlpp+Lt......sWhsth..htpl	..............................................................................hhh.........t..s.t............................................tttLt.shhp.......phts..t.sh..h....p..lp....scaspLF.............................t.s.hsS..halp...........................pc........hG.p...s....h...h.....cl+t.....hhp.ptGl.ph..s..s..........pE.........s....DHlslhL-hhuhL..t......................tht..................pphps.htphlstpLh...................sWsshF...h...h....................................................	0	194	410	579
+625	PF00877	NLPC_P60		NlpC/P60 family	Bateman A	anon	Pfam-B_292 (release 3.0) & Pfam-B_9022 (Release 8.0)	Family	The function of this domain is unknown. It is found in several lipoproteins.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.67	0.72	-4.22	28	11783	2012-10-10 12:56:15	2003-04-07 12:59:11	14	163	3617	17	2263	9076	1767	106.80	30	35.28	CHANGED	Gp.PYtaGGsssp.............GFDCSGhsphsatph.GlpLPRsuspp.................hthupp..lstsphpsGDLlFFps....tssssHVGlYl................Gssphl+us..usslp..........hsslpssaWppphhtstR	......................................................................GpPY.h.aG....Gs.s.sp...................................GhDCSGhs......p...h.s........ap.......p....t.....G......l...p.....L...P..R.s.stpQ......................................................h.p.h..Gp...t.............l...s....h....s....p....h...psG....D...L.lF.Fps..................ttsssHVGIY..l........................G..s.s...p.h...l..Hus.......upslp.............hs.s..h..t..p.s.h.att.h............................................................................	0	699	1509	1928
+626	PF04981	NMD3		NMD3 family 	Bateman A	anon	COG1499	Family	The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway [1].	22.80	22.80	22.80	23.10	22.20	22.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.82	0.70	-5.25	73	560	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	451	0	390	543	91	215.30	34	49.77	CHANGED	CspCGt...shcss.s................s...hCscChhpph.clsc.lscph...plthCppCsphhps.spWhps..tuc-lhslh.p.l.cs.l..........pcsh..hh-sphlhsEs...........pupclcl+lslps..plhs...s.lppshtlphhlptptCscCp+ht..sshacAlVQlRpp..........h.pchshhhl-phhh+tsttt.lsplpctc-.GlDhahuspstAp+hschlpsth.ssphpcotcLlup-tp.upp.Y+hTauV+l	............................CspCGs...sh..s.s.s..su...................s...hChsCl+ppl..DIoc..sls+p.s...........slphC+pCp+a......hps....sp..........Wlpst....ES+ELLslCL++l.csL...........scs+......llDAtFlWTEP..............................HS+Rl+l+lolpt.........Elhs....ssllpQsh..V-ahlptp.CscCp+h........stshWcAsVQlRQ+...........s.cK+ThhaLEQLll.K.tstpppslpIp.c.hc-.GlDFaaus+...spAp+hl-Flpshh..Ps+h.pp.SpcLlSpDhcssphsY+hTaSVcl.....................	0	138	235	327
+627	PF01234	NNMT_PNMT_TEMT		NNMT/PNMT/TEMT family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.75	0.70	-5.42	7	264	2012-10-10 17:06:42	2003-04-07 12:59:11	12	4	72	91	177	297	5	229.70	31	93.18	CHANGED	h-u..shhuspsahp+FsPcsYLpsaYph.Stsss..tp..llhahL.s....lhpphs.sthts-sLlDIGuGPTlYphLuhp-shc-IhloDasspNhpELt+WlccE.usaDWosslpahsplEG.....stsphp-hEpKhRttV+p..VLcsDVppsssl..su........s.lP..sDsVlohhslEsuCssLssYppAl+shsuLL+PGGaLlhhssLctohY.hGt+c.Fosl.LpcEhl.cAlhcuGhplpphp.....t..ttshhstcGlhhlsA+K	............................................................t..........t.h..pcFpPpsYLpp.Yt.....spt.........tt...............hh...a.hLpp....lhphF..s....s...tl....p.G.c..pL..lDlGuGP.TlY.p.lLSAschFc-IhhoDas-pNhpELp+W.L.............cc-..suua..D..Woshhpa.l.s.p.lEG......ptpp.hpE.+cccLR.ptlKp.....ll.sDV.ppspPl..ss............lP.....sDsl.l....oshCLEsss.s..hs.s..YppALcpl......ssLL+PGGaLlh...hs.s.....Lp.t...o........hY..hs...Gt.......p.c...asslslsc-.lcpAlt..cu..Ga.pl.php...........p.....t.sh.s.pu.hhhhhupK...................................................................	0	60	72	135
+628	PF04147	Nop14		Nop14-like family 	Wood V, Finn RD	anon	Pfam-B_8521 (release 7.3);	Family	Emg1 and Nop14 are novel proteins whose interaction is  required for the maturation of the 18S rRNA and for 40S  ribosome production [1].	34.90	34.90	44.20	35.60	34.40	34.30	hmmbuild  -o /dev/null HMM SEED	840	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.42	0.70	-6.62	37	404	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	278	0	286	416	7	609.40	24	92.83	CHANGED	s+tp+ppsltt..........IccphNPF-h+ss..+sKa-l......hG+p.scssp...ucPGlo+uhup-pR+pTLhtEhpp+sKsGuhlD+RFGEp.DsshosEEKhhpRFs+E+Q+p...+K...cshFNLp-DD-p...................LTHhGpoLu..........pD-.p-tcht...t..................pt.chtt........pp....tpspPp..R+KSKpEVMcElIAKSKhaKtERQpt+-csp-hp-cLDcs..hp-lhshL..psspp..t..........................ht...........spcph.c-YDptl+pLs..a-+RupPsDRTKT-EEhAcEEtc+L+cLEp-RL+RMpG...tsps-cppcpt......................ts-Dl-Ds.........................tahhs.s.pppspcp.........................................................uhps---tppD-D.p....t.pp.p.........pt..ptts-.Esptppcpt.......................................tspspsplsaTassPpoa--hhphlp..shshp-hssllpRItts..a+PpLttsNKpKLspFhul....Llp+lhaLusps.............shpllpslhphl+sLucp.....................aPpshupshRshlcch.pphct....slps.........s-LlhlslluslFsTSD+aH.VlTPuhlhluchLupsthp...olpDlupGhalsslhLpYpphSKRalPEllsFltssLhhh.............hPpcspp..........................s.sh..shpt.sstLp.......lsss...................pt..thpspp..Lphhclh........spppssph+lslLsshlsllppsss.lapsp...suahElhpPhhslLpphsp..................tsh.splpphhpc.lsphhststht..R+PLsLppH+PluI+ohtPKF.E-sFsP.c+Kp.YDss+ERsEhsKLKtphK+E+KGAhRElRKDspFlARp+lcEppccDpEYccKh++llsplpspEGcp	...............................................................................................t..............t.NsF-hphs.....t...Khph..............hst......t............t.ss...hs+t.u.ppRppsh...cht....p.t+..s.hhhD+R..h........G..E..s.p..h........s.E-+hhtRathEp.pt.......p+.....tshasLp-p-...........................................................LTHhGpsLt..............................t...-p.tpt.............................................t...htt...................................ttt.t....p.+o+pElhpElIsKSK...Khc+ptt+cp..t.p.htpLDpt..htpl.t.h...tt..t.................................................................................................................................................tt...ptYD.hh+..phh..h..-..h.+u.tss-RhKotEE.ht......tcp..tp+LppLE.............tpRhpRM.u......ppptp..t.t...................................-s.tct.............................................................h..t.........................................................................................t.t.tp.pp...tps...........................pt.t....................................tp...pt.........................................................................................................................ttthshsh..hPp......sh.pp.....h.thht...th........tp..........hhlp+l..th...pspLt.tN+t+ht.h..h....Llpah....hhpt..........................hth.h....p.lh..lhphsp.................................................s...hstthp.hltph.tp..t......................................t.LhhhphhuhlassSDhh.H.VhTPshlhh.......sphLtp..............h.h......shtphs.uhhlstlhhp.h.t...upRhhPEhh.ah.thlhhh......................h.t..........................................t......h......................l..t.................................................h.h..h...............t.phthl..hhthlpth....hhtt.....uh...hh...s.h..hlpth.....................................hpthhpt....htt...h.p.t.........ht...L....h..........p.p...p+...............shslt.......h.P+h.....p..s...hp..t..........c.......s.sp......p..ct....-h.t+hh..tphKcEhKus..h+ElR+DstFhtp.phpp.htpptthppKhtplhs.lttpptt................................................................................................................................	0	105	165	243
+629	PF04153	NOT2_3_5	NOT; 	NOT2 / NOT3 / NOT5 family	Bateman A	anon	Pfam-B_2131 (release 7.3)	Family	NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.	20.50	20.50	21.10	21.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.04	0.71	-4.28	66	799	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	308	0	526	782	7	125.90	31	23.73	CHANGED	lpsuhsss.pst...ss.pp..pap........Ppshh.......spps.........................phhp..phst-.....TLFalFYhh.s..shtQhhAApELppRsWRaHKchpsWhpR....t.....c.hs........sph...Ep...GsYhaFDhps...........Wpphc..c....sFphcYphL-	...................................................................sshts..tst...ss.....t..t...pap......Pps.h........h.spps.sh.............................................thhp..+h.sp-.....TLFalFYhh.u..............shhQhlAApEL.t...p........+sWRaH+chphWhpR..pt..p....pshs................................sph..Ep...GoY.haFDhpp............Wpphp..p.pFphcYphLp................................................................	0	187	299	442
+630	PF04065	Not3		Not1 N-terminal domain, CCR4-Not complex component 	Wood V, Finn RD	anon	Pfam-B_8081 (release 7.3);	Family	\N	25.80	25.80	25.80	31.30	25.50	25.70	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.69	0.70	-5.09	24	389	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	268	0	251	374	2	217.20	45	32.76	CHANGED	Mup.RKLQQElD+shKKVsEGlptF-sIY-Klps..ssNsoQ+.....EKLEuDLK+EIKKLQRhRDQIKoWhuss-IK.DKss..Lh-pR+hIEs......tME+FKulEKthKTKuaSpEGLp..sss......pl.DPc-pc+p-sspalssplDELpcQlEphEuEh-pl.sthKKt.ptst.spppchp-hcpthERacaHls+LEhlLRhLpNspl-s-pVp-Ic-DIcYYVEsNp-..sDFh.Es....-slYD-.Lsl-pp	.............spRKLQ...tEID+shKKVsEGlptF-sIapKlps.......ssNssQK.........EKhEs...........DLK+EIKKLQ.....RhRDQIKoWh...uus-IK...D........K..p...............Ll-....pR+.hIEs...........pME+FKsVE+EsKTKAaSKEG..Lu....tup.................................+l..D....P...tp.....+cKpEsspaLsssl-pLptQ.l-phEuElEsLps......p.......t.......+..Kt.....pts......p.....s..........c.....ppRlpclcphl-RH+aHlppLEhlL.RhLcNs.p.l.ps..-pl.p.c.lK-slcYYl-.....s......s...p-.....sD..F..Es.............-tlYD-LsLp..........................................................................	0	87	147	217
+631	PF03060	NMO	NPD;	Nitronate monooxygenase	Griffiths-Jones SR, Bateman A	anon	Pfam-B_2634 (release 6.4)	Domain	Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase [1,2,3], but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms [4]. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.86	0.70	-5.29	12	5886	2012-10-03 05:58:16	2003-04-07 12:59:11	10	43	3071	11	1913	12559	6372	309.60	26	84.17	CHANGED	psthschh.hp.slhtshhuh.hssscLAuAVSpAGGLGllu..uuhhos........DtLtpplptlcphTsc.PaGlNlhlsp.ttsc....................h...h.phthchuls...................................lluhuhGsP.tphlccl+puGshlhshsuosppActstpsG.......sDsllsQGhEAGGHpG......csu....thhhLlsplscsls.......lPVlAAGGItDs+slAAALsLGApGVthGTtaLsopEussssht+pthlpustccThhopshs.........G+stRsLpsshhcch-.....p..shshs.t.................................hsts....lptusspu...shctu.hhsGQstthlsclhsscpllpplsp-	..........................................................................................................................................................................................................................................................thh.thchP.l.l.p.u.....sM.uh.....l...u...ss.......cL.su.A..Vup.A.G....GL.Ghl.u.....u...u.t.h.ss...........................c..l.....c.....p.....p.l...p......t........h............+...........p......h.........s.......s.........p.....P............a.....u...l...N...l..h..h......t.......htt......................................................................................hp...h...hh.p.tsht..........................................................................................................................................................l..l...s...h.......u.......h.......G...............P................t.......p.......h..........h......p........t......h......+........p..........s......G........l.......h..........l......l.....s.......h.......l.....s....o.....s.....c..t....A...p....t....h..t....c....h.G..................................s.D.u....l....l.....s.......p..............G.....h.............E.......A...G..G.HhG.......................phs........................sh..s..L..l...s..p...l......s..s..s.hs....................................lP..Vl..A.AGG.I..s...s........G........c.u......l....s......A...A......h...........s...........L.......G.....A........s........uV....p....h............GT....t..F..l..so..p...E........u....s...s........p.t.......sa....K..p..t..l....l....p................u........p.........t.....p......D.........s......s..l.o..t.t.hs................G....h.s..s.......R.sl..p...s..p.....h..h.p..p.h.t...........t......t..h.t....h.........t.t........................................................................................hh.tt.........lpt.s..hhps........c..h..c....h.s........h.h.sG.pss...t..h.....l.....p...c..h...sstcllpplh..t.................................................................................................................................................................................................................	1	550	1189	1608
+632	PF05021	NPL4		NPL4 family	Wood V, Bateman A	anon	Pfam-B_13681 (release 7.6)	Family	The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome [1]. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.	21.10	21.10	21.30	21.50	19.60	20.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.92	0.70	-5.26	36	376	2012-10-10 14:49:21	2003-04-07 12:59:11	10	22	298	0	260	392	4	274.70	36	51.89	CHANGED	RhGaLYGpYccaspsPLGIKAVV-AIYEPPQ.psE.DGlsl.hs...pppppVDplApth..GLp+VGhIFTDLhsss.tpGoshhpRchcoaaLSuhEllhAA+hQhpaPp.s+aS...psGpFuSpFVTCllSG..s..suplshpuYQVSspAhuLV+ucllpsosp....Pshhhlpc........sspp..cYlP-VaYpchspYGtpVpc.A+P.FPl-aLlVslocuaPpsPp..........shF........psssFPlENRphhGp.........QshpsltcaLpsp...............sshhpplSsFHLLlaltph.thLs..pp-hthLscssp....pp..t.h.th.tpstsatsLlpIlp	...............................................RhGaLYGpYppap...p.h...PLGl+..AhVtAIYEPPQ......sp.-..u.lpl...hp........tptptVDplA..pth............GLp+...VGhIFTDLhs....ts.......t......t......GpVhhpR......p.h-oaa..LSu.EslhAuchQspaPp.s..+hu...........sGp.FuSpFVTsl..loG...s..t.s.s.plphpuYQlSs..pshtlV+sshltsstc.....Pplhhlpc................................sspt...pYlP...-........V....aYpc.h.s....c.a.G..t.p..lpp.A+P...hPV-YLlVs.....lstuh.PpsPh...........hF........ppssFPl.ENRphhGp..........sQshpsLtphLpptt...........................tp.hhctlSDFHL.LlaLh.p..t..h..hs..p...........cchshLhcssp........pcs...t.....h.ph.hts.tWtpl..l...........................................	0	96	146	219
+633	PF01909	NTP_transf_2	DUF76;	Nucleotidyltransferase domain	Bateman A	anon	[1]	Family	Members of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.40	0.72	-3.66	117	8895	2012-10-02 22:47:23	2003-04-07 12:59:11	18	121	3228	80	3285	7676	1203	100.00	15	25.51	CHANGED	lppltctlpphh......stplhlaGShsc.....Gphp.t.....SDlDlllhhspt.....................................hhhthtthhpphhshthDlh..............hhtthp.........hhhtphhppthhh	..........................................h.......h..t.h..........hhtl.h.laGShuc............G.p.h.pst........SDlDlllhhspt...........................................................................................h..th..t.....h...t.....h........h.....h..shh...................................................hh...........................................................................................................................................................................................	0	1095	2088	2757
+634	PF01759	NTR		UNC-6/NTR/C345C module	Bateman A	anon	[1]	Family	Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in [1]. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs).  The TIMPs are classified as a separate family in Pfam (Pfam:PF00965) [2]. This expanded domain family has been named as the NTR module [2].	21.90	21.90	21.90	21.90	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.74	0.72	-4.50	103	1259	2012-10-01 21:39:20	2003-04-07 12:59:11	16	55	160	51	605	1076	0	105.20	21	14.37	CHANGED	pc..hCps......-Ysh+spVhs.....hppps......shsthshpltpVhK....pu......th.ppsppthahtpt.....pC.phht...Gp.pYLlMGpt.........pptphphllsppohlchW.sptppphpchpp	...........................t.phCts......-a....s....l...ps+lhp..................h.ppps............shhph....s.s.p.l.p..plhK...............................pu..........ph.pcspp.p...hhh.pt........pCsplps..........sppYLlMG......................pptpsphlls.pohlthW.sphtpphpp....................................................................	0	82	136	315
+635	PF04142	Nuc_sug_transp		Nucleotide-sugar transporter	Bateman A	anon	Pfam-B_2311 (release 7.3)	Family	This family of membrane proteins transport nucleotide sugars from the cytoplasm into golgi vesicles.  Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.56	0.70	-5.27	10	1158	2012-10-02 19:55:49	2003-04-07 12:59:11	10	22	276	0	767	1530	427	213.10	26	58.73	CHANGED	+hscpL+ctlhsps...tDoLKluVPShlYslQNNLhYVALSNL-AATYQVTYQLKILTTAlFoVlhLsR+LuphQWhSLlLLhsGVAlVQhssssu.p.ssspss...........................................spN...hlGhsAVLsAChsSGFAGVYFEKILKsos...sSlWlRNlQLuhhGlhhuLls..salpDtspIs-pG.........FFhGYshhVWhlVlLpAhGGLllAlVlKYADNILKuFAoSloIILSoluShh.LF.DFplohhFhLGAhlV	................................................................................................................hh..................p....hh.h....u.l.P.u..hl....Y.sl.p.N.sLh.a.l....u.......l.s...l..s..su.s.....a.Q.l.hhp.h.......K......Il.......sT.A..lhshh....hLp+p..Ls.h..........h.Q..W..h.uLh.l.L.h.h.G..lsl..l.p....hs.....s.st..s........................t.....t...........h.......................................................................................................................................tp.......hh....G...h......hhl...l....h...us....hhS..uh...A..u..............VY.............hEt..l...L.K..p..p.t.....................s.l....a...h..p....N.......h......l.....h..huhhhs.h..hh...............hh...h.......t....h....t........h.......p..tG..............................................h..h..G....a....s....h.....s.h..h.hl.h................p.u.h..s....Glh.huh....h..h..+ass.sl..h..Ksassshuh...lhss.hh.S.hh.hh...s...h...s........hhhs..................................................................................................................................................	0	334	453	632
+637	PF04096	Nucleoporin2		Nucleoporin autopeptidase	Wood V, Finn RD, Rawlings N	anon	Pfam-B_5132 (release 7.3);	Family	\N	21.90	21.90	23.80	24.90	21.80	21.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.80	0.71	-4.37	57	473	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	294	19	304	507	1	137.20	35	10.65	CHANGED	sYahpPolppLpphohpcLpp...VpsFslGR.csaGpIpF...tsVDLssls.L-..............plVphps.+pltV.Ys-s...p..KP.lGpGLNlsApITL.sshPh...s+sspt.h.pspp.....hpcplcplpp.tpsscFlSY-s.sGsWsFcVpHF	...................sYas.PSh--Ltphstpc....hpp......V..s.sFslGR.cuYGplpF...tsVDLs.s.l.s..LD.................p.....IV.phpp..+.....plhV.YsD-..................sp..KPPl..GpGLNh.AplTLcssaPh..........s+ss+p.hpp.spc.h.....acp+lc+lpc.p.psscFl.s.Ycsp....o.....GsWsFcVpHF................................	2	113	182	263
+638	PF01733	Nucleoside_tran		Nucleoside transporter	Bashton M, Bateman A	anon	Pfam-B_2135 (release 4.1)	Family	This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways [2]. Also in this family is mouse and human nucleolar protein HNP36 Swiss:Q14542 a protein of unknown function; although it has been hypothesised to be a plasma membrane nucleoside transporter [2].	22.90	22.90	23.10	23.10	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.89	0.70	-5.26	7	1065	2012-10-03 03:33:39	2003-04-07 12:59:11	13	12	303	1	710	1041	14	251.30	21	65.30	CHANGED	hhtlslINu.hsAlhQsSlaGlAushPtpYosslhsGQuluGhhsolshl.lshAsssc....hptuAhhYF...hsuhlllllChlhh.hlphhcaY+hatphp.....................p.pt-hhpsccp...sp.s...stsshpp.............s..t.....h..hhsllppl.shshslshhaplslshFPuh.o..h.os....s....pp.aa..lssFLsFNlFDhlG+slsuhhhaPs...ssRhlshhshhRhlFlPLFhhCshtsp...+....hPshFcp-hhFhhhhhhFuhoNGYLsSLsMhhuP+pV..sccpEsAGtlhshFLslGLuhGulhSalhch	.............................................................................................................................................h....hh.h.sh....ssuh...hpsu.h.huhsu...hs.....p.a........hpshh.Gp.uhuG...................hh.......s.u.hh..l.....h.s.h...h......hsp.................................pt.s....shhaF...hhuh.hh....h...hs...h....hh.h...h.h.h......h............h....ht....h.h...t.............................................................................................................................................................................................................h.h.lh.......pphh.....h...h....hsl.hhhahlT...h.lFPu.....h..............h.....t......s...........................s................................h....h...........h............h...h....hhhaNhhDhhG........+.....h..s.t.........h..........h....................p..p..h.l.h..h.h...sh.hR.hl.h..l.Phhhhs..h..t....................................hh.t..ps.....hhh.....h.h.h...hhhuhoNGahsshshhh...u......P............p.....h...s........tpt.........phu..G.hhsh....hl....h..hGlhhGuhhuhh...h...................................................................	1	294	433	600
+639	PF04880	NUDE_C		NUDE protein, C-terminal conserved region	Mifsud W	anon	Pfam-B_6501 (release 7.6)	Family	This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration [1].	27.20	27.20	28.20	28.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.15	0.71	-3.89	3	274	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	162	6	163	251	0	178.10	37	42.72	CHANGED	SLEDFEp+LNQAlERNALLEhEl....DEKESLplclQRL+DEsRDLKQEL.hVpER.ppsNRKSRPoP...........V.susSlPo...TPss...psShsSP....+SlPNGhVoSPL..TPss+lSL................pLAu..ssA+DsAsspStTSuSVN.shshsSshsh.ptSussSFssRu....h.ss.PphsQuHSRspS	...........SLEDFEp+LNQAIERNAhLEsEL....DE.KEsLhlplQRLKDEsR.............DL+QEL.tVp............c+.........p....c....h....s....p.p.....s...tsos......................................l.p.ssh..olPu.............T.Pss.........ps..sh.sos..............................puh..s...suhu..u....oPL....TP..s..s.+...l.Su........................................plAu...shsps..us...ts..h...sss.hp..........h....t..........s............s..............s............................................................................................................................................	0	39	64	109
+640	PF00293	NUDIX	mutT; 	NUDIX domain	Bateman A, Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.73	0.71	-4.52	197	43912	2012-10-02 00:00:35	2003-04-07 12:59:11	23	282	5206	325	11753	31604	9218	130.90	17	65.32	CHANGED	hthusssllhspps..................clLlhcctps.................................................shaphPuGtl-..GEs.tp..................................uAhREltEEsGlph.......t.hthhthhthttsstt.....................................thhhhahsphtsst.thp.t.t.........Ehtphpahshpclhphhhthp.......hhtthhtt	.................................................................................................................................................h....shh.h.l.hptpt..................clL.l..h....c..ctp.t.................................................................................................s.h.a.p.h.P.u....G....t.l.....-.......u...E..o.......tp...........................................................us.hR.El..t.E..E..s..Glph.........................p.hph..h..s.....h.....h...t....h.....h...stt...................................................................................h.h..h...h....a..h....s....p....h..........t.....s...t..............h..t..t.t.......................Eh.t.p....h..t....a..h....s..hp.ph..p.h........................thh..........................................................................................................................................	0	3648	7193	9734
+641	PF03826	OAR		OAR domain	Griffiths-Jones SR	anon	PROSITE	Domain	\N	20.10	20.10	20.10	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.38	0.72	-6.56	0.72	-4.31	45	968	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	131	0	530	872	1	20.70	51	6.33	CHANGED	s-.+soSIAsLRhK...AKEHsss	......sp+soSIAuLRhK...AKcHus......	0	82	133	288
+642	PF03137	OATP	OATP_C;	Organic Anion Transporter Polypeptide (OATP) family	Mifsud W, Bateman A	anon	Pfam-B_626 (release 6.5)	Family	This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. [1] initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins (e.g. Swiss:Q92959) are also considered to be OATP family members. In addition, the methotrexate transporter OATK (Swiss:P70502) is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted.  Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null --hand HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.72	0.70	-6.46	16	1462	2012-10-03 03:33:39	2003-04-07 12:59:11	15	17	98	1	852	1674	81	439.80	25	82.67	CHANGED	hKhFllshslshhsQ.shssuahsSslToIE+RFplsSspoGlIsusa-IushllllhVSYFGu+hHRPRhIGhGsllhulGullhuLPHFhhs...................Ypaspss.sssspstsspLC.........t....p.stsstsspcptpshhallhhhuQhlpGIGsoPlhslGlSYlDD.scppp.SPlYlulhhshshhGPAlGalLuShhhplYlDhspss.t....lplsssDPRWlGAWWLGFLlsuulslloulPhFhFP+pLPcs.......................th....thpt.pspcpppppsppscstt........................................tpl+cF.pslhplLpNslahhhllupshpssshsGhhoFlPKaLEpQauhouupAshLhGslslPssulGhhlGGhll++a+lsspuhsthshhssllshhhhlshhhlsCssssluGlsssh............ss.tt.s.hssCspsCsCspstasPVCussGhtahu...........................shsusssssstsstp.spshssssssssspss..........tGhCsss..CspphhhalhlhshsshhsshutssshhllLRsVp.--KohAlGlphhhhRlLGhIPuPIhFGhlIDssClhW.uppC.Gp+GuChhYDssshp	.....................................................................................................................................hhhhhshh.h.......p....hh...s.hh.ssl..o.p..l.E+Ra...tl.S.t.sG.......hlsus...-l..u...shhhhhhlo.Ya..G.s..+..h..p.+P.phluh.G..........shlhuhushlhslPcFh....t............................................................................................................hp.ht.................................t.....t.......ht.....................................................................t.t...t......t............................h.h.hhhhhuphlhGhGtssl.slGhsYlD-...spp...pp.us.hY.....l.u..hh.s..hthhGPhhGah.l.uu.hh.hp...ha...h.......-.................t.l.s..p.c....s..pWlGA...W.Wh.....Ga..ll.suhhh...h.h...uhs.hhhh..P.+p...hstt...............................................................................................................t.............t....................................t...........................................................................................................................................h..p.th....s..hh..p...lhp.N....hahhhhh..sth....h....h...h.....h..uh.........hsF..........h.sK...al..E.........p.Q....a.........t...............s...........su............us.........hh.......h...G...h.....h.ls...sh..s.......h.GhhhGG.h...lh.p+...h....p.h..t..h..h....t...hh..t..h...shh.ht.h.h.......shhh.....h..hhhhtC........s.........h.u....G.ls.sh................................t.....s.Cs.ts.s..t..tshsh.ssh......................................................................................................................................................................................................................G..C.ts........t..t....h....a.hh.h...h..h.....h.hh.h.h.....s.ths........h....h..h....hl...R.........sl..p..+shulGh.thhhhR.h..h....u................hlPuPlhaGhhlDpsChhW...t..........p.......s....t...p.u....sChhYs...h......................................................................................................................	0	328	378	620
+644	PF05005	Ocnus		Janus/Ocnus family (Ocnus)	Moxon SJ	anon	Pfam-B_4799 (release 7.6)	Family	This family is comprised of the Ocnus, Janus-A and Janus-B proteins. These proteins have been found to be testes specific in Drosophila melanogaster [1]. 	20.20	20.20	20.20	23.60	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.43	0.72	-4.17	22	220	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	116	7	113	230	6	104.80	40	67.16	CHANGED	Lst.lPpV-lD.cGh.FKYlLlpltspt.....scts+.lVRGhstspaHs...DIa-clptphcphGl..ssc......................CLGGGRIc+csppKp..I+VYGaSpuaG+A...cHphopclLp..spYscY.pI	..................................................................Lht.lPpVcI-.pGh.aKYlLlplpsts..........spts+.lVRGht...s.c....aHs...DIa-clp....tchc....p.h.Gh..ssc.......................CLGGGRIpHpspcKp..I+VYGhSpua...G+A...cHshop-lLp..spYs.-Ypl.............................................	1	44	56	89
+645	PF00215	OMPdecase		Orotidine 5'-phosphate decarboxylase / HUMPS family	Finn RD, Bateman A	anon	Prosite	Domain	This family includes Orotidine 5'-phosphate decarboxylase enzymes EC:4.1.1.23 that are involved in the final step of pyrimidine biosynthesis. The family also includes enzymes such as hexulose-6-phosphate synthase. This family appears to be distantly related to Pfam:PF00834.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.61	0.70	-4.95	87	7126	2012-10-03 05:58:16	2003-04-07 12:59:11	19	18	4753	429	1546	4780	3008	216.50	23	86.65	CHANGED	spLpluLDhtst..............cchl...plscclss..lshlKsshslhpshG........hpllptl+pp.s..hhlhhDhKhsDIGsTstpthp.....hhphsAchlslpshsG..sslpuhhcsupphs.....................................................................................................tllhls.hoshsthshtp........hspthlcpttctp.t.............hh.Ghlsssp.s............................chhhlsPGlph............ttusstutphtts.thht.ttuchllVGRuIhtus.sPttsucph	..........................................................................................................................lhlAL..D..hpsh.......................................pps.h.............p.h.l.c..p....ls........s...ts....s....h.l.K..lGhthhhs.G.........................phl.c.tL.+.pts.............hhlhhDh.K............ht.DI.s.sTssptst.......................................................s......p........h.........u.......s........Dhlslpssu......G....hph....hcuuhcs..h.pphs.................................................................................................................................................................t.l.l.t.ls..hh..oshstp.phpp..hs..............tss..p...th.s.pp.h.tchttp.......................................t...Ghlsuspps......................................shhhls..P..Glp...................................psu.ss.s.s....pt..h...hhs..t.......s.t..............ss.......h.lllGRsIspAs...sPht.shct.h.....................................................................................................................	0	478	961	1295
+647	PF04084	ORC2		Origin recognition complex subunit 2 	Wood V, Finn RD	anon	Pfam-B_7065 (release 7.3);	Family	All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex.  The function of ORC is reviewed in [1]. 	19.60	19.60	20.10	20.00	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.09	0.70	-5.60	31	329	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	276	0	239	313	5	306.80	30	59.16	CHANGED	SspoLuplt......shlspccahphhpph.pth...pppphptL.chapph..............FtpWhh-LppGFsllhYGlGSKcpLLppFspphLss......................hshlVlNGa.Pslsh+sllpsIsphlh.t.............thhsppstcplphlhchhpst...................psclhlllHNlDGsh..LRppcsQshLupLushspIallAShDHlsuPLlWD........................ptct.ppaNFlaa-sTTatPYstEh..saps.sl..hh..............................................s.....+osp.....hutpuhpaVLpSLTtNu+sla+lLlphQLp.....................sptss.....pthGl-acsLappCpcpFlsSsEhshRohLsEFhDHKhlppp+sssGhE...............hLhlPhspspl	.......................................................Stpshtph....hlspp.phhphh.pp...h..t.....p.pchptL.p..a..p.p...............FspWhhpLpp.GFslllYGhGSK+pLLp...cFtpphhpp..................................................shlVlNG.ah.P.s...lsl+s...lLssIsptlhst...............................................tthhpps.ptlphlhphhppps...............................................................shplhllIHNlDush........LRp....s.ps.QphLupL....u..s.......hsp......IpllAShDHlN.sPL.lWD............................pspt...spaNalaa-sTTatPY............s.tEh....sats..pl..hl..............................................t........pssp.........hshpuhtaVLpSLT.Nu+sla+lLhphQLp.................................................sttss.....phhGlpapslYppspEpFlsoS-hslRs.LpEFhDHpllpp++.s.s.sGs.E................hLhlPhstt..h..................................................	1	83	134	198
+648	PF03392	OS-D		Insect pheromone-binding family, A10/OS-D	Mifsud W	anon	Pfam-B_3032 (release 6.6)	Family	\N	25.00	25.00	25.40	26.20	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.33	0.72	-4.01	91	701	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	96	9	258	733	0	92.40	40	73.06	CHANGED	YTsKYDNlDlDEILps-RLlpsYhpCLl-cG..tC.TP-GcELKchLPDALcTsCuKCo-KQKpuscKVlpaLhcp+P-.WcpLpsKYDPcspYpc+Y	........................YosKaD..s.l.sl--ILpscRLlpsYhcCLLcc..G...C.TP.-............G+-LK.....ch.l.....P-ALc.s.pCsKCo-+Q+psucKllcaLhpp+P-.W.ppLtsKYDPpspYtp+a....................	0	61	101	246
+649	PF04756	OST3_OST6		OST3 / OST6 family	Wood V, Bateman A	anon	Wood V	Family	The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs [1]. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation [2].	21.30	21.30	22.50	22.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.01	0.71	-4.67	19	672	2012-10-03 14:45:55	2003-04-07 12:59:11	8	15	309	3	385	597	4	142.80	26	50.64	CHANGED	hhh.Fh..hhclsph+lhhPs.lshP.hhlshhllllo............................aFlhsuGhhashIpssPhlspshcs.....psVsFh.tpsptQahhEuhhsuhlashsul....Ghlhlsps...stshs+p................chhhhu..Ghshllh.FhshhhF	.................................................h.ah..hhp..h........clh+Ps.h.shs.hh..h...sh.hl..s..l...l.u.........h..h.h..t............h....hh........p..+.hWhhhslhh.hhhhsSGhhashI+....tPPhstpsscs.....t.lsahts.pspsQ..ashE..shhsuh...la.shhuh....uhl.lL.s...p.......ss.........t...s..hsct...................c.hhhhh.....Gh.shlhh...Fh.h...h..........................................................................	0	117	190	292
+650	PF01010	Oxidored_q1_C	oxidored_q1_C; 	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus	Bateman A	anon	Pfam-B_41 (release 3.0)	Family	This sub-family represents a carboxyl terminal extension of Pfam:PF00361. It includes subunit 5 from chloroplasts, and bacterial subunit L.  This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.63	0.70	-4.86	113	14159	2009-09-12 05:40:05	2003-04-07 12:59:11	14	14	12076	0	124	13554	281	225.10	56	42.75	CHANGED	RIYLLTFEGHLs......laFpNYSG...p..+sssh..Y....SISLWG..K.cs.....Kt..ls+N...hhL.t............psscpsSF...Fs...K..phY..pl.........s.pN.l+phh..p...s.Fhsh.s..pF..ss..Kp..sh......YPaESDNTMLFPLLlLlLFTLFlGhIGI.P....Fs..Qtth.....slDILSKWLsP..SIN..................LL..HpNsss..S......h..DWYEFlp...NAlFSVSIAhFGIFIA.hLYpPlYSShpNhsLINSF..lK..hss..K.R..hhh..DKIlNsIYsW..SYNRGYIDsFYsphhotGIRtLAcLTpFFD	........................................RIYLLTFEGHLN.VHF..QNYSG......p...Kssuh..Y....SIS..L..WG........K..ct..sKt........lN+s....hhLhs..................ps..s..p......p......sS...F...FS..........p.......ch.Y.....p..I..............s..pN...s....R.....s.hh.....p........s..F..h..s......l...s......pF.....s.s.....Kp....sa....................sYPa..ES..DNTMLFPlLlLlLFTLFl......G.sI......GI..P...........F...s...Q...t..s..h.......-l..D..IL.SKWL..T.P..SI.N..........................LL........Hp..s...S...N..s....S......h....DW..Y.....E.F.....l..p.s..A..l..F..S..V..S.....I..AhF..G.IFIA...hLYpPl.Y..S..S.h....QNL..s...........L...l..NSF.........lK......t.uPK...R.........hhh...D+.I..h...NhI.Y.sW..SYNRGYIDs.FYsp.hhh..Gl.RtLuc.hh.pFFD.........................................................	0	38	87	111
+651	PF01483	P_proprotein	P; 	Proprotein convertase P-domain	Bateman A	anon	[1]	Family	A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain.	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.02	0.72	-4.20	75	1577	2012-10-03 19:46:52	2003-04-07 12:59:11	15	112	646	15	726	1507	250	87.90	31	11.11	CHANGED	lEaVplplslsHs.pRGDLplpLsSPsGspShLhs.pRsp.........D.tpsGahsWsFh......osptWGEsspGsWpLcl..pD.......................sstpppG......plpsWpLtl	.......................lEcVplpl.s.lsHs..pRGDLplpLhSP.s..GT.p.oh..Lhs..pcst...................................D...s.ps..G..h....h.sa.sFh........................................osphaGE....s.s...p.G...s...WpLcl...p.D..................................ps.stptG......plppWpLhh..................................	0	252	371	555
+652	PF04062	P21-Arc		ARP2/3 complex ARPC3 (21 kDa) subunit	Wood V, Finn RD	anon	Pfam-B_6413 (release 7.3);	Family	The seven component ARP2/3 actin-organising complex is involved in actin assembly and function.	25.00	25.00	40.00	40.00	18.30	16.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.01	0.71	-4.49	29	364	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	276	15	231	331	3	170.20	48	94.42	CHANGED	MPAYHSsFhs-st........phl..G..NhulLPL+TpaRGPA.................ssspshDIlDEsLsLFRANsFF+NFEIKusADRlLIYhhLaIo-CLpKL.....ptshstp-ApKtLhsLAl-.sFsIPG-sGFP..LNuhYphP.ps+s-uElLRsYLpQlRQELuhRLlc+lYs..sp.p................spPSKWWLsFsKRKFMsKSL	....................................MPAYHSth.s.t............phl..G..NhulLPl+..Tp.h....+....GPA.h................................ss.pchDIlDEslhhF+ANlFF+NaEIK.u.ADRsLIYlhLaIo-CLpKL.....pt.ssopspupKthhsLuls.pFsI.PG-s..GFP..LNuhYthP..ts+p.-...s...............-hhRpYLp.....QlRQEhuh.RLhc..+.Va..s..sp..s..................spPSKWWhsFsKR+FMsKSL............................................	0	73	121	183
+653	PF02331	P35		Apoptosis preventing protein	Mian N, Bateman A	anon	Pfam-B_13247 (release 5.2)	Domain	This viral protein functions to block the host apoptotic response  caused by infection by the virus. The apoptosis preventing protein (or early 35kD protein, P35) acts by blocking caspase protease  activity.	20.10	20.10	21.20	27.20	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-12.01	0.70	-5.30	7	25	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	14	10	0	29	0	301.10	58	92.61	CHANGED	MCVlhPs.hcssQTlIhDst...spphR-LlYlNplh....ss.lsKsVLMhFNISGPl+sVsR.hsspht-hhKSKlD......cpFsphp+sh.....SsphsGhc...+YFcs-cYoVsC.stsshKsKatKhLpscshs-ccsIEsacK.CL.P.......Lhsc..........psshYV..sVCsLKPuhtNs.uppsLSFpYpP.ssKVIVPhtHEIs-sG..hYcYDVh...AhVcuVp.....phcc.lQsLhh.pta.cs.c.lhascsshNcphhhhs.-FpTcshasKs....hpI.CNu.I.DccpchLhVKL+NVTspLscsl................ILsplc	...........MCVIFPVEIDVSQTVIRDCp..VDc.QTRELVYINKIM....NTQLTKPVLMMFNISGPIRSV.TR.KNN-LRDRIKSKVD......EQFDQLER-Y.....SDchDGFHDsIpYFKDEHY..SVSCQ......NGSVLKSKFAKILKSHDYTDKK.SIEsYEKYCL.Pp......LVDc..........+sDsYV..AVCVLKPGFENG.SNQVLSFEYNPIGNKVIVPFAHEIN.DTG..LYEYDVl...AYVDsVpFD.GpQFEEFVQpLILPSoFpcSEKVLYYNEASKNKNMIYKALEFTTESsWsK.SpKaNWKIFCNGFIYDKKSKsLYVKLHNVTSsLNKNV................ILshIK.......................................	0	0	0	0
+654	PF02225	PA		PA domain	Bateman A, Mahon P	anon	Pfam-B_259 (release 5.2)	Family	The PA (Protease associated) domain is found as an insert domain in diverse proteases. The PA domain is also found in a plant vacuolar sorting receptor Swiss:O22925 and members of the RZF family Swiss:O43567. It has been suggested that this domain forms a lid-like structure that covers the active site in active proteases, and is involved in protein recognition in vacuolar sorting receptors [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.23	0.72	-4.32	69	5065	2009-01-15 18:05:59	2003-04-07 12:59:11	17	204	1352	75	2693	4930	531	99.80	17	13.82	CHANGED	sstsstptsll................................tsstssssshtsssspGpl..lls.....pputs...............sh....hp+s....ttAp..ps.GAtulllhs.....................shststhtshslPsshl.spssGptlhphh	..................................................................h........................................................t.........t..t....tp..h..t.....s.h...s..l....p.G..K...I......sll...............pcG...s.s...................................sa..............spKs...............ppAp....ps...GA..hull.lhs.......................................t....st.............s...p.....s.h...t...l...P.shhl...s.ttuttlht..................................................................	0	704	1487	2130
+656	PF00291	PALP	S_T_dehydratase; 	Pyridoxal-phosphate dependent enzyme	Bateman A, Finn RD	anon	Bateman A	Family	Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16 Swiss:P04968, tryptophan synthase beta chain EC:4.2.1.20 Swiss:P00932, threonine synthase EC:4.2.99.2 Swiss:P04990, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22 Swiss:P35520, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4 Swiss:P76316.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.14	0.70	-5.19	148	31175	2009-09-12 08:45:30	2003-04-07 12:59:11	20	102	5380	356	8492	23404	13882	295.50	21	77.75	CHANGED	lp.thstTPLhph...................pla.hKhEshp..s.sG..ShKsRsu...hhhltp..........s.p............................ptl...lsuouGN......................................puhulAhsus..th.G..lp.s....hlhl.....Pps.sst..............t+hthhcthGA...pllhhstt.t.t.stst....phsp...t......h..h.hpt.................................ssstshtGhtohuh..El...............h....pph.........................p.h............llsss.GsG.GhhsGlupshpp..........ts.c..l.luVps..pss.....sshhpthtttt...................................................hht.ulshsh........................ssth.hthhcph...............h.....sVs-p-shp.uhptlsppp............G.lhs..tsuuussluus.ht......h.........t.tp..ll.hl.lsu	......................................................h....ht.TPLhh..........................h.tt.h.h.ss....p.la..h...........KhEs.......hp....s...sG.........S.......h.K.sRsu.........hthltt...................A.tpt......................................................................................st....psl..........lp.so...u......GN.............................................pG.h.u.l...A..h.s.us......th..G.........hc.s............hlhM.................Pps...hst.......................+htt...h.c.t..h.G.A.........c.l....l..h...s..s.........s...s......s.........t..h..h..s..t.st........ph.s....p....ph.......h.t...hp...................................................................................ts.s..s.h.t....tp...t..s...hu........El...............................................h...........ppht..............................tt.D.h..................................llssl...G....s.G..G..shs..G....l...u.t.hhpp.....................................sl..cl..lul-s........pss..........................s.sh.....h...t.s..h.t..s.s.p.........................................................................p......tht....Glshsh.......................................................................................sssh..s.hp.h..h..c.c.h..t............................hh....sl.s-p-....shp..shct....l....t....p....pc.....................G....l.ls.....s.s..u..u.us...u...l...sus...h.....p.h.t.t.p............................tspp...ll.hl.hs...............................................................................................................	0	2689	5306	7156
+657	PF00024	PAN_1	apple; Apple;PAN; 	PAN domain	Bateman A	anon	Patthy L	Domain	The PAN domain [1] contains a conserved core of three disulphide bridges.  In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.64	0.72	-4.22	89	2217	2012-10-02 11:41:37	2003-04-07 12:59:11	21	217	255	64	1525	2546	76	80.20	16	20.08	CHANGED	C..........atthtstthts......tshpth.ts....sshppCtptCt.....pptp.........Cpuasapts.....................pppChLpspspts.......................spltt.....stshshapp.pC	............................................th.h.s.......shpth...ts..........ohppCtptCt.....pptp.............C.puas..apsp.......................pppChLpspspts........................................th...............h..h...........................................................	0	624	791	1265
+658	PF01569	PAP2		PAP2 superfamily	Bashton M, Bateman A	anon	Pfam-B_486 (release 4.0)	Family	This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.46	142	14398	2012-10-02 00:53:37	2003-04-07 12:59:11	16	88	4426	44	4448	11648	1667	132.00	19	47.04	CHANGED	thhhhhhshhh.............shhl....s.h........h....Khhhs..p..sR...Phhhhtth..h.....................................................uF...PSGHs...shuhshhhhlhhhhtphhhh...................................................hhhhhhshhluhuRlhhuhHahsDllsG....hhlGhhhsh.....hhhhhhtthth	...........................................................................................................................................................................................................................hhh....hhhshhh........shhl...........s.h..............h..........Kth.ht....c.......sR......Ph....h.h.h..h..h..h....hh...........................................................................................................................................SF.......PS..GHs...........s.h.u.h..s....h....s..h....h...h....h....h..h...h..t.th.h.th.......................................................................................................................................hhh..h..h.u....h.h.luh..S.R.l.....hh.G.h.Ha.sDl..lsG.....hhlGhh.hshhhhh.......hh......................................................................................................................	0	1276	2479	3559
+659	PF03828	PAP_assoc		Cid1 family poly A polymerase	Griffiths-Jones SR, Wood V, Mistry J	anon	PROSITE	Family	This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity [1][2][3][4]. Proteins in this family have been located to both the nucleus and the cytoplasm.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.09	0.72	-4.02	112	1402	2009-01-15 18:05:59	2003-04-07 12:59:11	14	49	312	22	919	1373	27	60.60	28	8.69	CHANGED	sLGpLLhpFFcaYu.p............pFsapphsIul....ps.uth....hsK.pphthh.......................t.thlsIpDPhsssp	...........sLGpLL.hpFFcaYu..................cFsapcpsISl....+p..uth........ls+.pp.t.t.ht..............................................................phlsIE.....DPhp.s.................................................................	0	290	439	704
+660	PF04928	PAP_central		Poly(A) polymerase central domain	Wood V, Bateman A	anon	Pfam-B_1341 (release 7.6)	Domain	The central domain of Poly(A) polymerase shares structural similarity with the allosteric activity domain of ribonucleotide reductase R1, which comprises a four-helix bundle and a three-stranded mixed beta- sheet. Even though the two enzymes bind ATP, the ATP-recognition motifs are different.	20.50	20.50	20.60	20.90	20.10	20.40	hmmbuild  -o /dev/null --hand HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.59	0.70	-5.57	36	745	2009-01-15 18:05:59	2003-04-07 12:59:11	12	32	320	11	465	707	14	304.90	37	49.06	CHANGED	pppa.....GlT.PlSts.Psst-hphoppLhctLpptssaEop-.-sp+RppVLppLppllp-aV.ppluhp+shspphspssuuplasaGSY+LGVhusuuDIDslslsPpplp+........pcFFssFhchLpppsplscltsVt-AaVPlIKhpasGIplDLlFApLslsplPc..sl.sltDcslL....+slD-pslRSLNGsRVsDpILcLVPsh....csF+hsLR.slKLWAp+RulYuNlhGF.GGVuWAlLVARlCQLYPNAssus...llp+FFplaspWpWPp....P.........VlLpphpcs.......hthp..VWsP+h...spD+hHlMPIITPAYPshsuT+NVopSThpllhpEhpRuhcIspclh.........hsp..tsWpcLaEth	.........................................................................................................................................................hGho.slShs.Pp..-h.hsppL.p.Lp..sha.Espp.....Ehp+..............R..........lLt.pLp.p...llpcal.pplutp+shstthhttssutlhshGohplulhs.suDlsslslssphh.......................................................................................................................................................................................ppaFt.hhphht.t.plpclpsV.cAaVPlhchpasGlplDllaAplsl.plP..p...sl..clp...sc..s..lL.....csL...D..ps.lR.SL..N.GsRV..sDpI.Lc..LV.Psh.............psFRhsLR.slKhWA+.+.............Rul..YSNhhGFhGGVsWAhLVA.RsC...Q.............L.Y....P.N....A.....s.sus....................lVp+FFhla.sp..WpW....Pp..................P........................................VhLpt..-css..........Lth...VWsP+h.....................pD+.......hHhMPIITPAY.Pp.NuoaNVo...hSThplh............hcEhpp..G..htlspcl...............sp....tpWspLFp..............................................................................	0	142	239	368
+661	PF05028	PARG_cat	PARG; 	Poly (ADP-ribose) glycohydrolase (PARG)	Moxon SJ	anon	Pfam-B_5996 (release 7.6)	Family	Poly(ADP-ribose) glycohydrolase (PARG), is a ubiquitously expressed exo-  and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death [1].	20.80	20.80	21.40	21.10	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.14	0.70	-5.20	23	357	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	168	8	240	364	7	279.40	30	52.28	CHANGED	asc.h...p..ct..Fhp.h............LP..ths+lsLplsslh.t..............sl.lLtpppspplhlopcplusLLAsuFFshhspp.................ttt.sphPsh.NFspLap....s.ptpsphpKlKClhpYFcpls.......pphssGhVoFpRhth................t.pphs.WppsstsLp....plclhscutIEDp..tshLpVDFANKalGGGVLspGsVQEEIRFhIsPELlluhLFscshccsEAlhIhGApRaSsYTGYusoFpa......................pGpa.Dpp.shDphpR........+pTpIVAIDAlpa.......pshhp..QacpstlhRElsKAasGFh...ptptpspphs...................................................................sluTGNWGCGuFuGDscLKslIQhlAsS...................tspRshl.YhTFGDppLpshhp	.......................................................................................................................................................................................................h.............ht...h............hs.hhphh...hph..h.h.................................................h.hl.....t...s..t.l...hop...husLlupsFhshh..t.............................ph...h.sF.sph..ht......t......tt.........pKlpslhpYFppht............tph.psh..lshp..Rp.h......................................................p.....ht..ppt.h.ht.....hph.............ps.....h......IE..pp.........th.lpVDFANch...lGG.Gsh.s.t.G.hl.Q............EEIhFhhsPELl.luh.Lh..hp.......hppsE.slhlhG..spp...a...SpapGYu.p.oapa..............................tt.p..h..ctt.....h....c..t....htc...........htspllAlDAhph...........t.t...p....Qat.ptl.RElpK..A.....h.s.G.Fh.............t..t..hs...........................................................................................................................................slu..TGpWGCGs..F.s.Gc.pLKhllQhhAuu....................s..t.+s.hh.Yhsatp..th.....hh...................................................................................................	0	114	147	209
+662	PF01734	Patatin		Patatin-like phospholipase	Bashton M, Bateman A, Dlakic M	anon	Pfam-B_2206 (release 4.1)	Family	This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of  the total soluble protein in potato tubers [2]. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids [2]. Members of this family have been found also in vertebrates.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.36	0.71	-4.40	116	10726	2012-10-02 11:19:24	2003-04-07 12:59:11	17	127	3394	5	3812	8861	1395	181.80	20	39.60	CHANGED	LslsGGGs+.G....hhphGslpt....L..................................tththphchlsGoSsGulsu...................................................hhhshs...hs.pphhpthtphhtpthhshh..................................................................................hhhthhtttshhssphhtphlp......ph.......................lsptthpphttththh.............................................................................h.ht.tttthhhhttptts......stplhp..............................slh...ASs..uhPshh....................................tshph........ssp.......ha..........hDGG......lh.ss....hPh.phsh	.............................................................................................................LsLsG.G.Gs+...G.....hhp.hGllcs................L.........................................................................................tp...tsh.h...c..h..l..sGoSs..Gul.su...........................................................................................................................................................u.hh..s.ss.............s..s..t....t.....h...h...th.h.t.....p.h...ht.p.hh.ht.h....................................................................................................................................................h.........h..h......t....t....s....h....h....p.....s...p...h....h.t..ph.lp..........................ph.....................................................h.s..t..t..t.h.p.p.h.h.t.....hhhh..................................................................................................................................................................................................t....t..s.....h..h....t..h.t...h..h.h.s...............................p.t.p.l.h.p...........................................................................................................s.lt.............ASs...............ulPsha............................................................sh..ph........................................sup..................................................hh.............................................................lDGG.........lh..ss...hPht...h.......................................................................................................................................................................................................................................	0	1192	2259	3131
+663	PF02460	Patched		Patched family	Bateman A	anon	Pfam-B_2400 (release 5.4)	Family	The transmembrane protein Patched Swiss:P18502 is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	800	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.61	0.70	-13.13	0.70	-6.63	9	2194	2012-10-02 18:57:54	2003-04-07 12:59:11	13	37	648	0	1317	3841	1223	372.80	15	51.82	CHANGED	hhs.chhahhs.sDhp.shtphtshspp.shs.pcahsucuhststa..hhlsupspss.......lLp.shLs-lhplschlhpsh.......................tl.pss....h.hsacclC.pa.phspsspphh..................lhpp.ps...pthslTYPhhphhsptlYlusphuGVphhs.......................ssplp.s+shhLhahschsscpscphuppaEppLtpalcpp.ssp..hlphshhpsphls-Elp+suhshhPhhslohhlLhsFohlssh..h.p...........lppKPhlAhhGllsshhAhlouhGhLhhhGh.assIssVhPFLlL.uIGVDDhFlhlsAWc+Tstpps...........hccRhucslsEuGsuIoITShTslloFulGshTshPulplFChhsulAlhFsalYQlTFauAlhulsschEhptppsh..h.......hs....p................pphpspsuh.....................................................t.upphpp..hhs.....chhhshYssFlhssps+lhslhlallYlsluhYGshshcpsLsPspLlhs-S.Llchhp.h-chlaptGttlplhVpNPPslsh.spshcchpphhscFEshsashGtpuTpaWLp-Ypp.h.p......php.hpspc..................h..hsthcpalthsttsh.Wtpshhhs......cssstlppFhFplu..hcshsshss+s+hhpphRslAcpas...FNVolFcp.thasDQh.plhssslpshlhsllsMhlVshlFIsp..sshslshulsSIslGVhGhhShWGlsLDPloMlsllMSIGFSVDaoAHIuYtahpsttp....sspcRlhsALpslGWPlhpuuhSTlLslhsLhhVsoYhlhlFhKTlhLVlslGhlHGLhhLPllLshhss	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..................................h.......t....h.....................a................................a..h..-..t..h.............h...............h..........h....h.s.h....h....h...h.h.h...l..s....h..h.h..h....................p...h.....s.......sh.h.........h..h..h.s..l...h....h...........h.....t...h...............h...G...h.......h..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..........................................................................................................................................................................................	0	483	664	1096
+664	PF02170	PAZ	ZAP;	PAZ domain	Bateman A, Song JJ	anon	Bateman A	Family	This domain is named PAZ after the proteins Piwi  Argonaut and Zwille. This domain is found in two families of proteins that are involved in post-transcriptional gene silencing. These are the Piwi family and the Dicer family, that includes the Carpel factory protein. The function of the domains is unknown but has been suggested to mediate complex formation between proteins of the Piwi and Dicer families by hetero-dimerisation. The three-dimensional structure of this domain has been solved [2-4]. The PAZ domain is composed of two subdomains. One subdomain is similar to the OB fold, albeit with a different topology. The OB-fold is well known as a single-stranded nucleic acid binding fold. The second subdomain is composed of a beta-hairpin followed by an alpha-helix. The PAZ domains shows low-affinity nucleic acid binding and appears to interact with the 3' ends of single-stranded regions of RNA in the cleft between the two subdomains. PAZ can bind the characteristic two-base 3' overhangs of siRNAs, indicating that although PAZ may not be a primary nucleic acid binding site in Dicer or RISC, it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.	23.30	23.30	23.40	23.40	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.61	0.71	-4.86	55	1915	2009-09-11 14:14:06	2003-04-07 12:59:11	17	66	319	37	1147	1880	5	132.50	21	13.63	CHANGED	tsll-..hhtphhpppptpt.p.ppp........hpcsltGlhVhspaps........+pa+lsslshcssspppFphp...........spphohs-Ya+ppYslplphs.p.Phlhsppppp................................................saLP.ELCplsshpchhppphsh..pshhh+tpsps	.....................................................................................................................................hpctlp...G..hh.V.s.p...aps................+pa..p.lssl....sh..p.................s........s..p.p.....pF.hp...............................spphohh..cYapp+..Y..s..l...pl...p...hs..p.PhL..p.sspppc...........................................................................................saLP..E...l..C..p..l..s....s.......hp.chhpchtph...hshhh+hp.................................................	0	337	545	909
+665	PF00564	PB1	OPR;	PB1 domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.68	0.72	-4.32	53	2276	2012-10-03 10:59:06	2003-04-07 12:59:11	19	126	339	38	1408	2199	10	83.30	18	13.97	CHANGED	shplKhpatssht+........hphspsh.sap-Lhptltpththt........tshplpY.Dc-t.-hlslssDcDLppslcphct............t.t.pl+lhlhss	........................................................thKhpats.phht.........hths...t...s....h..sap....cLhpplpphhsh......................tsh...plpY...........h...D...-..-...s...-........h.ls.lss-pD...Lppul.phhpt.............................lplhl...t..........................................	0	348	710	1054
+666	PF00786	PBD		P21-Rho-binding domain	SMART	anon	Alignment kindly provided by SMART	Domain	Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.09	0.72	-3.55	44	1824	2009-01-15 18:05:59	2003-04-07 12:59:11	23	43	302	22	1078	1667	2	56.30	28	11.27	CHANGED	tISsP.ssacHhsHVGaDspsG.hh.....GhPppWppllpss..........hsppc.tppspsshpshtahs	............tISsP..os.F....c.Hs.sHV..Ga.D.st.s.Gths........................GhPtpatp.llpps..................................hpp.p...p..t..h.......t......................................................................................................................	0	294	490	775
+667	PF01161	PBP		Phosphatidylethanolamine-binding protein	Finn RD, Bateman A	anon	Prosite & Pfam-B_5394 (Release 7.5)	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.37	0.71	-4.35	128	4705	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	2779	40	1522	3605	238	145.50	26	74.89	CHANGED	sshlshpa..............hp.Gssl..sPsh...hpsh..Pp..........................ssp..s.asllhh..............................DPDA.....................htsah.HWl......lsNIP....................................s..pshssh...................up.............................hsYhGPsPP.Gss.hHRYhFhlauhss................sh.ptssst...sp..htpsh.................ppa...Lsps.lsus..ahp	.................................................................................................t...h..pa..........t.htsG.ssl.......oPph...hssh..Pt.................................ssc....t.as.lshh..............................DPDA..Ps...........................tpsahHW..l..........Vss.IP....t..t...lsts........................................uhh..ps..t.s.sh............Gp..............................ssYtGssPP...........G.............pt..hHR..YhFh..lauhss..............ph..sl...stssst....s....hthth...........................ptpt..Lups.lsuha.............................................................................	1	420	841	1251
+668	PF01399	PCI		PCI domain	Bateman A	anon	[1]	Family	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.03	0.72	-3.72	77	4727	2012-10-04 14:01:11	2003-04-07 12:59:11	22	54	409	7	3184	4579	40	109.70	16	22.45	CHANGED	.shtpllpshppss.hppatphlpph.................................tthhtp.hhtt...........hhppLhpplhcpslhplhp.......applshppluptlplss.....................splEphlsphIhsstlp.upIDph....sthlhhpc	....................................................................................................................................................hhplhps.ht.psp.hpt.h.tp..h.l.p..ph........................................................tt.h.h.t..p...h..hhp...........................hh.p.p.Lh.p...plhpps.lt.p.hhp............................sappl.s.lsplupt...l.p.lss....................................pclEph.ls.phI.tsst....l.p..u..plD.ph.sthlhht.t.................................	1	1114	1760	2604
+669	PF03462	PCRF		PCRF domain	Dlakic M	anon	Dlakic M	Domain	This domain is found in peptide chain release factors.	20.80	20.80	21.00	20.80	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.45	0.71	-4.39	100	9136	2012-10-03 10:28:09	2003-04-07 12:59:11	13	15	4731	15	2219	6114	4472	113.30	38	32.37	CHANGED	c...htppsDt-...ht..p.hppElpplp.pplpplcpc......hsh..sth..Dp.pssllEI+uG..sGGsEAs....aAp.LhRMYh+aA-.p.+........uacscllc..hstu-h.u.......GlKpsslplp.........Gc..........tAYuhLKhE	..............................................th....ttsDt-.ht..c...s..pp..El.pp.l........c.p.c.lpp.lE..c........L..l.p...........cst..Ds.....pssh.lEI+u........G...........uG..GsEAs....aAu.LhRMYpRaA....E....p.+..................Ga+sEll-.......hs.tu-h..u....................GhKplshplp.............Gc...........sAYGhLKhE..................................	0	757	1443	1875
+670	PF02153	PDH		Prephenate dehydrogenase	Bateman A	anon	PSI-BLAST P20692/1-290	Family	Members of this family are prephenate dehydrogenases EC:1.3.1.12 involved in tyrosine biosynthesis.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.53	0.70	-5.50	10	4258	2012-10-10 17:06:42	2003-04-07 12:59:11	12	22	4077	29	1083	3244	2767	243.70	25	69.28	CHANGED	lAhuL++pG.tsplhGhDhsstpsttAhcLGlhDssss..lptsp-A..DlllLAVPlcsstclLcclus.tlccusllTDluSVKscllcshcphls.phtpaluGHPMAGoctsGstuucssLF-spshlLTPspc.Tssptlppl+cllcthGA+lllhsPccHDpssulVSHLPHllAhuLsstht..chpsshc.sh+hAuuGFRDhT....RIAuusPhhWpcIhhpNscslh-tl-catpclsclpphlc....spDt-...sLhchh+p	..............................................................................pl..h...shs...p........t.t..h....t......u......t.......s...h..h..p...t.......h.......t...t......h............p.....h....l.....t....p.A..............-.llllus.P..l.p.t....s...p.h....l...p...c...l.......ss...........l......t.......t.....s.s.........ll.....sD.l.u.SsKs.s.l.l.p.t..h....t....p...h...h......s............................s............phl..u.u..HP....M.s.Gsp........s..G.....s..u.ps.sL.a.p.st..h.hl.ls............ss.........c............t.......s.........s.................p....s.......h....p....h....l...t.p...h.h...p...s.h.G.A.+.lh.p.h.s.s.p.-HDpshAhl...S...HLPH..ll....u...hulstt.ht..........pp.s....t....p..h..p.......h.....hp....h.....u....u..s....u....F....R..-....ho.....R....lA....u....s....s.P...p.h...ap...-Ihhs..Npp.llphlcpa..tppl.sphhp.hlp..........psD.t.p...thhphht.p....................................................................................................................................................	0	337	710	930
+671	PF04166	PdxA		Pyridoxal phosphate biosynthetic protein PdxA	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesised  de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalysed by  the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate [1].	19.70	19.70	19.70	19.70	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.99	0.70	-5.21	16	2867	2012-10-02 21:08:39	2003-04-07 12:59:11	7	6	2310	19	692	2198	2820	293.60	39	88.25	CHANGED	h..tpc..hpp.s.phVllu-tshL..ppttthhshp.l.........slcchp.....s..p..shh.hlt.hsL.th......s.sh........h.GcssstsGthslchLscAsphshsGphsullTuPlsKsslppA....Gh.asG+TEaLA-......hss......sc.....pslMML.ssp......cLRlsLlTsHlPL+-VssslTtctltphlcllpcsLppcaGItpP+IuVsGLNPHAGEsGhhGpEEh-pIh.....................Pul-phR..tpGlslh.....G.....PlPADTlFpts........tttth...DAVLuMYHDQGLhslKhhuF.spuVNlTLGLPalRTSsDHGTAaDlAGpG.hAcssShhsAlchAs	......................................................................ttt.......h.phllhu-hplL....p.p.t.s....th.l....s..ls....l..................................p.lps.hp......st.....s..p..........t.........s.s.hh....sl....h...s.h...tt..............s..lp........sGplsstsGphslcsl.pcAschsh.....sG.....ch.....sAllTuPl..pKt.s..l.pp.A...........G....h...s......FsGHTEal...uc.....hst...........................s.p........c.sl.M.ML..u..s.c.................................pLRVuLsTTH.lPL+clscslT.ptlppslpl....hppsL......+p..........cF....G.l..spP....R.IhVsGLNPHAGEsGhhG.p.EEh...-.h.Ih..........................................................Pulc..p..h..+......tp..G..hp.lh......G..........PlPADTlFp.t.........................hh.s.ph.........DuVlAMYHDQGL.sLKhhuF.....s...........c.........uVNlTLGL..PhIRTSVDHGTAhD.......lA....G.....pG..pAcssShhsAlphA............................	0	212	441	582
+672	PF00934	PE		PE family	Bateman A	anon	Pfam-B_253 (release 3.0)	Family	This family named after a PE motif near to the amino terminus of the domain.  The PE family of proteins all contain an amino-terminal region of about 110 amino acids.  The carboxyl terminus of this family are variable and fall into several classes.  The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis [1].	20.60	20.60	20.60	21.10	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.30	0.72	-3.90	135	4012	2012-10-01 21:44:22	2003-04-07 12:59:11	15	13	103	2	365	2559	0	90.80	46	26.20	CHANGED	MSaV.hssPEhluAAAsDLuuIGSsluAANAAAAuP.TTuVlAAuADEVSAAlAALFuuHuptYQslSAQAAA.FHppFVpsLsuuAuuYAuAE.AAN	..................MSaV.hssPEhluAAAs-LusIG.Ss.luAAN.A.AAAus....TT.ull.A.A.uADE.VSuAlA.A.LFuuHuptYQulSAQAAA.FHppFVpsLssuuuuYAsAEAu......................	1	142	177	350
+673	PF01095	Pectinesterase		Pectinesterase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.20	21.20	21.30	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.76	0.70	-5.85	35	2674	2012-10-02 14:50:22	2003-04-07 12:59:11	14	76	936	20	1177	2391	56	228.80	26	55.97	CHANGED	slVVApDGSGpa+TIsEAlsssP.c+uspR...aVIYlKtGlY.cE.NVcVsKcKtNlhhlGDGhsKTlITG.phshhcGs.TTFcoAThAlsGcGFlA+DIsFpNTAGPpKHQAVALRVsuDhulFY+Csh-GYQDTLYsHSpRQFYR-CsIsGTVDFIFGNuAsVFQsCpIhs....R+PhssQ.pNhlTAQGRpDPNQsTGlsIQsCpIsuss-Lh....ss.sshtTYLGRPWKpYSRTVlMpShIsshIsPtGWhtWsG..sFALcTLaYuEYpNsGPGussupRVKWsGa+slhosp-AppFTlupFI.tGs	...........................................................................t..t...a.plttAl.t..h....................................................................hl....l..G...Y...................E.......l.......l..................l...h.......G...................s.................................s..........................h.....................................t...........................................................................t.....................s.....s...............h..............p.............o....A.......o..........h.......h.........s........t........u......s.....s.hh...h....p..s........lsh........p............N.............o..............h...............G............s..........t.......t............p..............p....A....V.........A..l..p..s..s..u..D..........p.s........hh.....ps..ph........h.Gh.QD.Tl........a...........s............p...........s............s............R.....p...........ha.p...........s..shIpGslDFlaG..p.u.s....s....l.F....p.ss.plhs.........h....t.....s.............t......t...........t.....s......h....l....s..A...u.p................s...t...............h..........Gh........hh.pspltus.....t........................................h.LGR..s....W..........t................h......u................p..............s..........h.......h..s.hs..........t...l......G........a......h................................................................h...............ph.s........G.s.................................................................t.....................................................................................................................................................................	0	261	757	995
+674	PF04710	Pellino		Pellino	Mifsud W	anon	Pfam-B_5882 (release 7.5)	Family	Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase [1,2,3].	20.00	20.00	20.40	34.90	19.30	19.90	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.47	0.70	-5.83	8	257	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	97	3	152	252	0	347.90	58	92.85	CHANGED	up-ptsu.scpsl....+YGELIVLGYNGsLPsGDRGRR+.S+FsLpRRs+ANGVKPSshHhl.poPpsSKAlssKsQHSISYTLSRspoVVVEYsHDscTDMFQIGRSTEsPIDFVVhDT...........lPGu....t-sp-stspQSTISRFACRIlC-RsPPYTARIYAAGFDoSpNIFLGEKAsKW...psscGcMDGLTTNGVLlMHP+sGFo.E-SpPG...lWRElSVCGsVYoLREoRSAQp+GphV.p-sNlLQDGoLIDLCGATLLWRousGLp+sPT.+cLEtllpclNAuRPQCPVGLsTLAFPphp+.......tss.s-+QPWVYLpCGHVHGaH-WGpccEpt.p.cRcCPhCRsVGsY...VPLWhGsEPAFYlDsGsPoHsFsPCGHVCSEKTstYWuphPLPHGTpAFpAACPFCAs.LsGppGal+LIFQs.PLD	...............................................................at.LllLG....YN..Gs......Lss.G...D.+....G.RR.........+.S+hsLh+RscANGVKssshHhh.soP.......suKA...lp.s.+...sQHSIS..YTL............SRspoVlVEYscDssTDMF..QIGRSTEs.IDFVVoDT.............................hsGu.........s.ss-s.tssQSTISRFACRIlC-Rps.P.aTARIaAAGFDSS+NIFLG..............EK..AsKW.....................+ss.D.Gp.MDGLTTNGVLVMH.Pp...sGFs...p-S.....tPG......................lWREISVCGsV.aoL..R..E......oRS...A..QQRGKhV............EsEoNhL.....QDGoLIDLCGATLLWRTu...........p..G.........L.+...........sPTh...+pLEuhRpElNAuRPQCPVGhsTL.....uF..Pohtp...............................pps.sc.cpQPWVYlpCGHVHGaHsW.........Gp.cp....-........p...t................s...........p.......p..........RcCPhCRtlGPY.VPLa.LGpEs.....uh.....a...lDsGP.PoHAFs.PCGHVCSE.KTstY.WuplPLP.HG...T...c.sF+AACPFCut.Ls.....G-pshl+LIFQs.slD.....................................	0	35	49	95
+675	PF02452	PemK		PemK-like protein	Mian N, Bateman A	anon	Pfam-B_2134 (release 5.4)	Family	PemK is a growth inhibitor in E. coli known to bind to the promoter  region of the Pem operon, auto-regulating synthesis. This Pfam family consists of the PemK protein in addition to ChpA, ChpB and other PemK-like proteins. 	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.78	0.72	-3.85	306	4707	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	2273	13	846	2702	289	106.10	23	83.07	CHANGED	c+G-lhhlsh.....ts..sh.GsE.......tt.hRPs........lllsss..hhs.ph..t......slllsPlT.o....pht.t...............shcltlp.s...pt..pt....................ohlhs-plpolc.+p...Rl....t.c........plGp...............ls..spphppl.ppslthhl	......................................................+G-lh.h.ssh......tP.......s...GsE.................st..t......RPs........lVlsss...hhN.ph...s..........slllsslT.o...........php.t.t......................................................................shcl.ls..sp.....th..t.......................uhlhh-plpols...+p.Rl..........t.c......................plsp.......................ls....p.p.h.h.p.p.l.pptlth..h..............................................................................................	0	269	586	752
+676	PF01804	Penicil_amidase		Penicillin amidase	Bashton M, Bateman A	anon	Pfam-B_1410 (release 4.2)	Family	Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins [1]. Also in the family is cephalosporin acylase Swiss:P07662 and  Swiss:P29958 aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	21.30	21.30	21.80	21.70	17.40	20.80	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.03	0.70	-5.50	21	1530	2012-10-03 21:14:07	2003-04-07 12:59:11	13	8	899	125	501	1655	2079	651.20	21	92.28	CHANGED	tsVcIh+Du.aGlPHIhAssptslhauhGYspApDRLhpl-hh+tpApGphuchhGs...........stlssDhhh+phthsp......ssctphpshssp........tshlcuYusGlNtYlp....t.tp.hPh-ashhshp........Pc.asshDshtlt.hhhhphsus.............h......t.hhshasshh.t..................................h.tshs.hts................h.thstthsspsts.............hGSNsWsluup+TssGpslLhssPHhsatsP.shahphpLps.suaclhGsohsGhPhl.hhGaNsplAWuhTsstschhDhYt.pls.p.ssspYhas.Gpapshcp+ppsltV+s..sp.....shphplhcThcGPVlspsss.............sshshthsshtpsspsh.sahphscAcslpphpp.s.tpthtssshNhhaADtpGsIuahssuhhPh....pss.ps........hhPssG........uph-WpGhhs.hpt...hPphhsPs.......pGalhsuNppsh.........ssshsht.hssthhts.....hRspphhphlstpss.........hshcshhplphs.stshhschhh.................llcshp.........ssssssppAhstLtuWstphsssopuAs.........lathahcthsppshhsthst.hhsshhs.h.......................s.h.hssssshh.tttp.........sthlspuhspuhs..................hpsphG.................shshpWGchpp.........hh.hpshshpu.........sssshs.hhGshsshsssths.sstsssshtsshs.....hphss.hspsttlhssupSusPtSPHYsDQh.haspspahslhhs.pplptphpt	.........................................................................................t..splhcDt.hGlPHI...hA.p...s...tt.c...hha...u...GYspApDRhaph-hhR+hut...Gpluchh..G.................ttlt....Dt.hhRt.h.thtp......ssptt..h.s.t.h.ssps...........pphl..p...uYssGlNsalt............t...t...hhPh.-a.thhsht........s.t.W.ps.Dsl.hh..h.....hhh.hh..ph...tss.......p.................h..............h.................t.....h.....s...h...h.s.t..........................................................................................................................t...........................................t.hh........h..........................................................hGSNsWslusp+o.tsGps.llss.sPHh.sh.t.h.P....shaa..........t.hp....L........p.......h....s..........t................h.......s......lhGsshsGh.Psl.hhGaNt...........c.lAWuhTs.sh.s.D..Dlah.phs...............t....p......s.......t..t.....Yh......h.s...s......t........h..hp.tp.pp.sl..tV+s...st...............shp.hslh....T..t.a..G.Pl.lpts.t.................................................thshuht.h.sh..t...s...s..t.s.h....shhthsp..A..psh..pphhp..s.h........pt......h.t..h..s.s.Nhlh...AD.......p...G..s..I..uahssG.thPhR.....tthps.....................................................hhPssG.........psp.hp..W.p........G.h.hs..hpt.........hPp.......hs.Pt..................pGalhsuNsp.h...........................s.shsh......hs.....thh.s..........Rs...pcl....t....p...h....l...t...t...t.tt...............hs.hpsh..t.hphD..p...hs.......h.u...p...hh......................................................h.hp..hhp..............sts..hp.ph....hp....hL..t.t..W...st.ph....sh.....sshush...........................................lhthah.pt.....h.h...p...t...h..h.t...s.t.h.s...........h...ht.....h..s.........................................................h.........s.....s......h...h.t..t.......................hsthh.tts.h.ttsht..................httt.h.G.............................pht.W..Gphpp...............hh.hts.h.s..h..s....................................h.hs...s..G......s..t.t.s.h..t...s..........s..t...h...t.......................t......t....h............h...h..usu...ht...........hlhs...h..sc....s....tuh.h.h..hs.hGp.S.G.ps.hS.....saatDthp.ha.h..p.s.p.hhsh.hp.tth.....t..........................................................................................................................................................	0	178	337	452
+677	PF01469	Pentapeptide_2		Pentapeptide repeats (8 copies)	Bateman A	anon	Bateman A	Repeat	These repeats are found in many mycobacterial proteins.  These repeats are most common in the Pfam:PF00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to Pfam:PF00805 [1], however it is not clear if these two families are structurally related.	20.30	20.30	20.50	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-9.90	0.72	-4.32	126	12308	2009-01-15 18:05:59	2003-04-07 12:59:11	13	89	95	0	878	9127	90	40.00	46	47.97	CHANGED	uNsGshNsGsuNhG.hNhGsuNhGshNhGsuNsGstNsGs	......................NhGhhN.sGs.sNhGh...hN.s...GssNsGhhNsGssN.sGhh.NsG...............	0	480	495	874
+678	PF00391	PEP-utilizers		PEP-utilising enzyme, mobile domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.	23.00	23.00	23.10	23.20	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.57	0.72	-4.41	179	11592	2009-01-15 18:05:59	2003-04-07 12:59:11	18	59	4567	47	2573	8381	2287	81.70	31	11.56	CHANGED	pspp..t.hh.ps...ILVscc.lsPuphs..hshppltGlloppG.Ghs...SHsAIlARshGIP.sllGs.t.s.............shpt......lps..Gphlhl...DGppG	.............................ts.....t.hsps..sILVsc.c.hsPsphs......s.h.p...ps..tGllTsp..G.GtT...SHuAIlARshGIPsVlGs..s..s.....................sspt..........l.ps......Gc..hlhl...DutpG...................................	0	893	1669	2174
+679	PF05131	Pep3_Vps18		Pep3/Vps18/deep orange family	Bateman A	anon	Pfam-B_6057 (release 7.7)	Family	This region is found in a number of protein identified as involved in golgi function and vacuolar sorting. The molecular function of this region is unknown.  The members of this family contain a C-terminal ring finger domain.	20.50	20.50	20.80	20.50	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.82	0.71	-4.77	31	318	2009-09-11 06:43:15	2003-04-07 12:59:11	9	7	276	0	229	324	2	145.80	26	15.40	CHANGED	GlhaGplshsssss.........pplhppspl...........h.psplssspss............hulsLTpaHlLlLhts+lhAlNpL.stplVa-psl.........hpstpphlGlssDs..tpsThWlaospslFElslpcEsRclW+lalcppcF-tALpas+s.....ssp+DtVhstpu-ahhpc	...........................................................GlhhGpl..t..ts...........hhsptph...........h...st.hststss.................................huhsLTpaHhllLh..s..s..+..lhslspL..st...p..lVhcpth.........hpthtphhG...lspDs...............tp..s..shWlaTsp.slFclhlpcEs...................RslW+laLch............pc............F-tAhpas+s..........stphDtVhttpu-hhhp.p.................................	0	82	129	192
+680	PF03051	Peptidase_C1_2	Pept_C1-like; 	Peptidase C1-like family	Mifsud W	anon	Pfam-B_2136 (release 6.4)	Family	This family is closely related to the Peptidase_C1 family  Pfam:PF00112, containing several prokaryotic and eukaryotic aminopeptidases and bleomycin hydrolases.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.53	0.70	-5.96	13	1894	2012-10-10 12:56:15	2003-04-07 12:59:11	10	5	1149	26	416	2017	382	362.80	34	93.53	CHANGED	pLos-plppFspcasucPphtlspsAsp+sGlh-Ashsc.psptchspVFSh-lsT-..sVTNQKpSGRCWlFuALNshRHshhKcaclc-FEhSQuYsFFWDKlE+uNaFh-pllsTA..DcslDuRhVpaLLssPppDGGQWDMhluLlEKYGlVPKpsaPEo.asossSptLNshLsc+LRccAltLR.pLhppGss.cplput+-chLsEIa+lluhsLG.PP....csFsaEYRDKDKNYHp.+slTPh-Fac+YVs..hDLcsaVsLlNAPpsD+PYsKlYoV-aLGNVsGGpplhalNlsh-hLKchslsQlKsGEuVWFGsDVu+ph-RKsGlhDsclYph-plFslchph..oKA-RLcaGEShMTHAMVlTGVDl.ss..Gpsp+WKVENSWG-csGpKGYFVMSDcWFcEYsYplVVcKKaLPc-llcsh-p...pPIsLsPWDPMG	.....................................................................................................................................................................................s.lp.p.htph.tph....ts.t.thhtpuh..p.s.sl.ts...p...ps..h.........p.....s....s.Fo..h..c.ls..pt.....tls..sQc.tS.GRCWhFuuLNshRh.thhpph.p..l.....c.....p..F.EhSQ...sahhFaDKhE+uNhFh...ppl.......lt..ou..........sp.hssR...hV...palhps.P......pDGG.Q.Ws.M.hsslhc.KYGlVPpps..h...P..Eo...h....s.o....p..so....pt.hs...thLs.ph....LRp.....u..h.LR...phh.t........p.............s..................t............s..........................t.................t.........l..........p..tt+pphL...ppla.phlshsLG....PP....cpFsa.t............a.......p......D.c...-.......p............p....a..p...............t.t......shTP.pFacc.als..........hs..........l.p.-....Y....V.s.lhN.s.....P...c.+sas+.asl-h.sNlhs..u....p....hpa.lNlsh-th+ch.shsp.l.p..sGc.s.V..........WFGsDV.u.p.....s.p.c....t...G........l..............h.........................s...h......sh....a......ch........p.......t.....h........h........s........h.....p..........h.p...............sK..u..............p..........R......................L..........p...........ht..................-.......S............hh.o...HAMslsG.....Vc.......l.....ts.......G..............p.......s..p.+..W+V.E.....NS..W.....G.....c......c...s...G...p..........c.......G.aa.sh....o..-sW..hccas...aplVVcKchlst.....-...hth....hpt....ps.h...L.sWDPh.................................................................	1	131	242	329
+681	PF00112	Peptidase_C1	Cys-protease; 	Papain family cysteine protease	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.92	0.70	-4.47	157	7017	2012-10-10 12:56:15	2003-04-07 12:59:11	18	153	1160	373	3137	7739	473	199.90	29	53.16	CHANGED	lPpshDWRp..ptss..VoslKsQG...pCGSCWAFSssuulEuthtlts.....tphlsLSEQpLlDCst....sp..........GCsG.GhhppAapalhp....sGls.oEssY.......PYp.....upc........................spCchp.ppp.h.....sphssass..lsts.......sEpsltptlsp..GPl.uVulsusp....sFphYpuG..........lapt...pCss......tlsHuVhlVGYGsps.....................................GpsYWll+NSWG.ssWGE.pGYh+htR...shs.....spCG..Isspsshsh	..................................................................................................................................................................PtthDhRp..............h....l.s......l....+..s.Q..G..........p.C..........G....S...........C......W....A.....F........u......s.s.......u.........s...lE.......u...tht...h......t......s..........................t......p.......h.......h..............s..........L......S...t.....Q....p......l.....l.....s....Cst.......tst.............................G.C...s...G....G..h..........t...t.......A.a.....p...alhp............t.G..l...s...s.-...p..sY.............................P.Yp..........utp...........................................................................spCphp....tpt..................hphp.s.a..hp....ls..s.......................pptltp.t...l.h..p........G.......P...............l...............s...su...............l........p....s....t......p...............a..................h.......Y......p...s...G...........................lapt................ssp................th..sHuVhlV.G...a..G.s.p.t..............................................................................................sh...Y..Wll+..........N.......SW............G.......p.p.........W.....G.-...pG..Y.hph..tt...s.t.........Cs.lt.......h............................................................................................................................................	0	1477	2033	2663
+682	PF01650	Peptidase_C13		Peptidase C13 family	Bateman A, Caffrey C	anon	Pfam-B_1302 (release 4.1)	Family	Members of this family are asparaginyl peptidases [1]. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation [2]. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified.  This has formerly been characterised as a 'haemoglobinase', but this term is probably incorrect [2].  Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue.  Both forms have been recombinantly expressed [3].	20.40	20.40	20.40	20.50	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.83	0.70	-5.09	34	952	2012-10-03 02:24:44	2003-04-07 12:59:11	13	35	545	0	478	982	50	226.40	30	53.62	CHANGED	pWAVLVAGSsGa.NYRHQADlCHAYQlLc+.tGlcsEpIlVhMYDD.IAps.pNPhsGhlhNpPp.....u.....pDVYpG.VshDYsGpsVsscNFhuVLhGscstltt.usGKVlpSsssDplFlYaoDHGuPG...lluhP....ts.LaAp-LhcsLpphHspspYpchVhYlEACESGShFps..LPpslslYAsTAuNucESSausYC.............sssphsTCLGDhaSVsWhEDo-t.pslpt..cTLppQachVKpcT.......ptSHVhpaGDhslsp.hlsp.a....................................................hGs	.......................................................................................pWuVllu.s.S.p...hahN.Y.RH..AsshphYphl+c.hGl.-ppIllhhhD..D.hAss..............cNPhsu.lh..sp...p.............t....slY..t.s..l...........hDYpu..cVssc................sFht..lLh...G.ph............spt+....hl....o..s.s.ps.p...l....h.............lYho.sHGuss...............hLth........sspplts.......t-Ls....cs.l.p...phat....cp+.................Ypph....lh..hl-sCpuuoh.............hpt...............t.s.......s......lh......s...hsuo.p.ssEs..Sa.up...h...............s..phtshlsD...h...a...o..h.......hhc...-p..............p.p....sltp.ap....h.....................................................t........................................................................................	0	181	292	392
+683	PF00863	Peptidase_C4		Peptidase family C4	Bateman A	anon	Pfam-B_232 (release 3.0)	Family	This peptidase is present in the nuclear inclusion protein of potyviruses.	20.80	20.80	20.90	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.49	0.70	-5.40	39	1088	2012-10-02 13:45:52	2003-04-07 12:59:11	14	30	161	9	0	1336	7	226.80	49	9.57	CHANGED	aEupShhpGlRDYNsIus.......slCpLpNpSsutppslaGIGaGshIIoNtHL...F++NNGp....LplpopHGpF..plcNosplplp.lpG+DlllI+hPKDaPPFsp+l+FRsPpps-+lChVussFQppphsspVSEoShhhs...ssusFW+HWIoTp-GpCGhPlVuspDGtIlGlHS.....LsstssspN...aFsshscsF.pphLpshcphpWsptWpaNsspluWuulplhsspPpt.FphsKhls	............................................HESpShaRGLRDYNPIusslC+LsN.sS-utssshaGlGa..G..sh..IlTNpHL...FcRNN.Gp....Lpl+...SpHG-.F...slKNTspL+l.h.P.It.....s...RDlllIRhPK......D....hP...P.F......Pp+.LtFRp.PccsERlC.hVG..o.....N...F.....QpKSl.o....S..hVSETSshhP............lts..SpF..WKHW...IoT....cD....GpCGhPhV...STp...DG..p...IlGlHS.....LAN.p.sopN...aFuAFs--Ft.pcYLpsh-sp......cWl......KpWpYNsstlsWGoLplpsup.Pp..u...FKloKLlp...................................	0	0	0	0
+684	PF02902	Peptidase_C48	Ulp1_C; 	Ulp1 protease family, C-terminal catalytic domain	Griffiths-Jones SR	anon	Structural domain	Domain	This domain contains the catalytic triad Cys-His-Asn.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.61	0.70	-4.72	27	3178	2012-10-10 12:56:15	2003-04-07 12:59:11	14	120	647	37	1892	3126	158	164.70	15	27.92	CHANGED	palsstlhthhhchh........pstpppcsthhsohFhshLp.....h................pphhsuspp.hpt......hhchDhlahPlp.h........stHWshl....hlsltcp.......................................pIhhhDSlhshpp..........htshsthh.aLhpp..hhptp..t..............p.ht.hhth.plPQp.sstDCGsashpal-hhspshs.p.........l...ppchtth+pchuh..hchhtstl	.....................................................................................................................................................................................................................................................................................................................................t...t.p.h..l.h.lPl.p..................ttHWhLh.....llsh.ttp.............................................................................................................................................................................................................pl.h..hhD..S.h..t.ttpp.........................thh.p.th.h....p..h.l.....tt.....h.....t.....................................................tth.t....h....h....h...............t....h..s..p..Q..t..s...s.......c..CGh.alh....t.hh.ch....h....hp...t.........................................................t.h.....................................................................................................	1	468	899	1346
+685	PF03416	Peptidase_C54		Peptidase family C54	Bateman A	anon	MEROPS	Family	\N	25.00	25.00	25.50	25.40	20.40	23.30	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.91	0.70	-5.27	14	700	2012-10-10 12:56:15	2003-04-07 12:59:11	14	10	298	10	424	693	4	260.10	32	62.57	CHANGED	pshhpsFhpDhtSRlWhTYRcsFssI.............................ssoshToDsGWGCMlRouQMLLApALlhp+LGRsWphstp.....................................................pppttapcIlphFsDp...susaSIHphlph..............................Gtpt.sKp......sG-WaGPsssupsl+pLscts.....shssl.plaVuhDsslhh--.hppss.....................................................................................................tstapPlLlllPlRLGlsclNshYlctLppshphspSlGIlGG+Ps.puhYFlGaQsDcllYLDPHhsQpslshspcshs......................................................poaHs.phhp+lphpphDPShslGFhC+scc-F-shppplp	..................................................................................................................t...tthhpDh.S+.l.Wh.TYRptFs.sl....................................................................................................................................s..s..s...s..hToDsGWGCMlRsG...QMlLAp........uLlhth.....LGR..s.Wp.h...tt....................................................................................................................................................t.t..thhpll.p.....hF..hDp.............p.....usaSlHph....sph................................................G.ht....GKp.......sGpWa...GP.ss....suphlcphs..t.........................th.ssl...tl..a...l.s...Ds.sl.h.h...p-hhphht...............................................................................................................................................................................................................tth..pslllLlPlRLG.h.p.p...l.N....h.Yhpslc.....thhp.h........tslGlhGG+P.p..puhYF.lGht........s..s..p.l.lYLDPH.h.s.Qsh.l...s....h.p.t..t.s..h.......................................................................................................................................................poaHs...pp...p+hthtphDPS.....hsl........GFh..sp..s.pp-apphppth.t..............................................................................	0	158	222	329
+686	PF01433	Peptidase_M1		Peptidase family M1	Bateman A	anon	Swiss-Prot	Family	Members of this family are aminopeptidases.  The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues.  This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activity [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.50	0.70	-5.38	33	7280	2012-10-03 04:41:15	2003-04-07 12:59:11	15	83	3187	81	3135	6965	1743	332.40	23	43.69	CHANGED	RLPssltPh+Yclplp...sphpsh.......sFpGpssIplps....pp.sssplslcspc.lsIp.slplps..psss............hphptppph....lplphspshtttp........hpLplpasu.lss....s..htGhYtohYhp....sGpp+hhssTQhp.sstARpuFPCaDEPshKATFsloltpssph..sulSNhs.hpsp.hp.ss..hthspFppT.shMSoYLlAahlu-hphl..pspsps..tl..lclaucsuttppup..aAL-hst+hlpahEcaashsYslP.....KhDhlAlP.-Fuu..GAMENWGLlTYREssLLh-.t..ostppcppluplluHELAHQWFGNLVThcWWssLWLNEGFAs.ahEahssctlts..phphhphalhsph..ppshttDuls....ss+Plp....plssPsplsshFs.slsYsKG	................................................................................................................................................................................................................................................................................h.................................................h...u.........h.h..................................t........h......l....p.........t......hp..l........t....h.....h.................................................................................................................hh.l.............t.........h..............................h.l...l..t..ht..s.........tt.......................t........htG...h..a............h.........................t...p...t..........h..h..........h...TQ.....h.E.....s..p...........ss.R...p.......hhs....s....h....D....c..P.........s.h..+.........A..s.........a.s.h.p...l....ts..s...........psh..............hsl.....SN..t...s.....h......h.......p..........p...........t...............t.........h....t.....s.....................hthh....pa......p.p....s.......h....s.o..Y...L..hA....h...s.s.G....c....hphh.................php..sps....................t.h...lp.......l....a....s...p............s....t.........h....p..p.st...........as....h..p.......h...t..p..s.h.p.a...h.c....c......h...a...s...h.....Y......s....hs....................p.h..p.hl..sl.s.....p..F.....sh.......G...AME..N..h..G...L.......h.a..p...p..p...h....l....L....h......s......t........t....s..............s...................t.....t........h........t..............pl..tt.....l...........l.u..H...........E.h.u.Hp............W.h.............G..N..h..V..T.h.c...........W..p..p.L...W.L.pEGass.ah.p.h....h.......h..s.s...p.h......ts.........................h.ph....................p.....h...h.h..p.th.................t.h.t........Ds..s...........s.cslp.................t..p........p.h..p............ph...as..hhsYtKG.........................................................................................	0	1008	1673	2600
+687	PF01431	Peptidase_M13		Peptidase family M13	Bateman A, Dudgeon T	anon	Swiss-Prot	Family	Mammalian enzymes are typically type-II membrane anchored enzymes which are known, or believed to activate or inactivate oligopeptide (pro)-hormones such as opioid peptides. The family also contains a bacterial member believed to be involved with milk protein cleavage.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.42	0.70	-5.15	21	3320	2012-10-03 04:41:15	2003-04-07 12:59:11	16	34	1562	10	1433	3043	301	191.10	36	29.63	CHANGED	NAaYssshNplshstslh.sPaassphs..pshNaushGsVluHElsHsFsspGspas..h............tah.tpspssapstspCslcpasthsssstst.....shsGspThtEslADluGlphAhpshpp......psss-ppl.s..hpt.s..phhahshAtsaCp.pppspstlh....psHuPsphRlNsslpshPtFsssFsCp.Gs+MascPcpps	...............................................................................................NAaYsPtpNp..I.sFP......A...........u.I.LQs.P.F.a.....s...h.p.ts..........puh.NY.GuIG.s.VIG.HEl.oH.uFDs........p.G....t..p...a...D...tpG.s.Lp............................sWW...op.p...s.hp..tF.p..p...+sps...hlc.Qa.s.....s.h.......ps.........h...............s............s..................................................p.........l...........N...G....p..hT...lu..EN..IA......Dh.GG.lphA....hc..Aap........................th.p..p...t...p...h..ss.........h.p........h....s..tQ.........h.FF..........l................sa..A................p............l.Wp................t........p....h......p.......s.....c.t..........h......t.............h....l.t..s...D........s.......H.u.Ps.......c.h..R....sss.s..lpNhsp.Fh..csF.sspt.u.ss.Mh.s.cpcl..................................................................................................................	0	539	753	1171
+688	PF05193	Peptidase_M16_C		Peptidase M16 inactive domain	Yeats C	anon	Yeats C	Domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.01	0.71	-4.61	181	16090	2012-10-02 15:41:56	2003-04-07 12:59:11	16	64	4451	253	5211	13286	2764	179.20	14	37.15	CHANGED	slstpplppahpphYpss.phslhlsGslshp..plhphhp....chhuplst.........................................................................tsp.hthsht..thttt.hhh.tt.........s...pspltlua.sssh...........................................sp.cthshpllspllust.........................htutLhpplp...............cpsh...shsstuh.hptht......ttuh.hslhhssssp......phpc............hhphhhptlppltpp.t...hsppc....lpcs+pth	.......................................................................................................................................................................................................................................................................................................................................hshppl.hp.a.a.p.p..a.Y..p.ss..p.h..s..........lhl...s...G...s........h..s..........p....p...h.h...p.h...hp.......ch....h.u..p.httt...........................................................................................................................p..ht.h....s..h...p.............t.......t..t....t..t.h.h.h.tpt..........................s....p..p.spl....t..l..u.....a..p.....ss..sh..........................................................................................................................s.p...c.t....h..s...h...p......l...h....s....p.l.Lust.................................tu.t.L..hp.p.lp..........................cp.sl.......sh..s....s..t..u..t...hs.sht..................t.uh...h.....t.....l..t..s.s..s..s.sp...........phpp............................hhp.h.lhp.t.............l...p.pl.....t..pp..s........hspp-...lpphpt..h............................................................................................................................................................................	0	1802	3187	4395
+689	PF02789	Peptidase_M17_N		Cytosol aminopeptidase family, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_990 (release 3.0)	Domain	\N	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.42	0.71	-4.38	103	3629	2012-10-02 00:07:53	2003-04-07 12:59:11	12	10	3099	51	1002	2638	1020	122.30	21	24.73	CHANGED	lls..lh..........cssthssss..........lc.pthsu.hlpphhpptshsGKhGpshh..lhshs.sh....hppllllGLGcppp.........hstcsh+pssusssctlps.hpsppsslhls...................ttspshspGhhLusYca.sca+opp	...................................................................hs..s..........tthc..th.su..hlpt.l.lcp...s...p.....h.p.G.K..Gpshh.....lhtss...s..................sp+llllGhG....cppp...............................h.s.t.c.ph+ps...hu..pshpsL...ps...t...........ts.tps.shhls.........ttts.................ttsptssc..usthutYpF.cpaKop............................................	0	310	592	816
+690	PF02127	Peptidase_M18		Aminopeptidase I zinc metalloprotease (M18)	Mian N, Bateman A	anon	IPR001948	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.40	0.70	-5.98	9	1876	2012-10-02 19:46:12	2003-04-07 12:59:11	10	13	1229	44	661	1854	254	401.10	32	91.82	CHANGED	FlspusTPaHsVppltc+Lh.ptGFppLpEppsWt..l.pPts+YFls+NtosllAFulGsphcstsGhslluuHTDSPsL+lKPpuppp.sptah.lulpsYGG.Ih.poWhDRDLuluGhVhlKss..tpph.phllclccPlhpIPsLAIHLs+sh.pshphspcschhslhuh.s......p..h.sptc..........pth+hslLpllscchG...lps-D...llsh-LhlhDspsuplsGhcccFlhusRLDNphssasuhpuLhpstps......csphplsshaDpEElGSsoupGAcSsaLptVLcRlshthppss.....hhpptl....sKShhlSADhsHAhHPNYsspH-psatPhhstGsVlKlssNtR..YuTsusstshlcplAptss...V.lQhhhl+sssPsGoTIGPhhuucpGlcTlDlGss.LuMHShREhsustDlh.shphapuFF	.....................................................FlstusosaH...........sltphtphLp..ps..GFp.pLpE.........p..c.p.Wt..........h..ps.....u..s+.aahs+ssusllAat...lsp...p......................t......p...G..................hpll.GuHsDSPsl+lKss....s..php.......ppG...ah..........l....sschYGG.lh.tsWhDRsLuluG+lhh+.................ss.......................t...............h..........st.ll.c.h.scPlhtIPsL.AIHLs+..p.h.p.p..s...h..ph.s..ppp...ch...Plhuhhs................................t..............................................hc.tl.hpl.l.sc..phu..........lp.tc-......llsh-L.lhssp.uphhGhs....p-....hltusRlDshsssasulp.Alls....stt........................................................................t...................p.......st..lh.s.haD+EElGS.totpGA....pSshlps....slpRls....t..s....h..s.tsp............t.h.pthh.........................spShhl.SuDsuHul.H....PNY...s.c...p.a-............s...p.ps.hlstGsVlKhss..spR......Yuosuss...s...s...h...h...p...p...l...s...p...p.ss........................lshQ.pahhpss...sGoT.lG.s.hh.s.u.p.h.Ghp....slDlGss.LuMH.ShRE..hsuttDlhhhhchhpuFh...........................................................	1	270	456	592
+691	PF01546	Peptidase_M20	CO_pept_M20; 	Peptidase family M20/M25/M40	Bateman A	anon	Pfam-B_253 (release 4.0)	Family	This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [1]. Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null --hand HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.37	0.71	-4.79	366	29469	2012-10-02 19:46:12	2003-04-07 12:59:11	23	76	4930	91	7433	26828	10363	326.10	13	78.41	CHANGED	hltuHhDslP.......th......p.s...................................GhhaupGpsDtpuhlhuhhpslpph........ttphps.slpllhpssEEsu.....u........................Gsphhhcs....................................hth+....shsh..sc.s.hts...............shpushshhhhhhsspuptussshssssshhhsshhhhhhpthhspttsshpssshshs.......................................................................................................................thsssssssshsttshhtsthpshppthpthhpthhtthtpthstthttttthphhtshssshsss.h....hphlpps..spp.h...................t.ph.sssuu...pDhshhtt........s.sh.hlshusts...........thhHs.ssEpls..sslhtusphhtphltp	.......................................................................................................................................................................................................................................htuHhDs.lP..........t...tth.........................t.................................................................................ps...s....h..h.....a....u....p....G....t....s....D.t...p.us....l.h...u.h...h....t....s.......l..pt.h..................t.t.p.h.p...s....s..lp.l..l..hp..s....s..E.Esu...t.........................................................................Gsp..t.h...hpp.........................................................................hthc.........shsh.........sc...s...t.th.......sttsssttththttttsttsstttsstshhtsshhhhthhthhtttttt.tttthhhhh.....................................................................................................................................................................................................................................................................................................................tsssstssh.thtthttthtthttphtthhttthtthttthstthththphphh.sh.hs.sst......h...hp.h.h..t..ps....hpp.hhh....................................ts.p.h.t.s.h.t..u.u...........pD..s..s...h.ht..................................t.s.h.s...h.l..h.h.usss.................tthHs....s...s...E...t.l....s....hps.l..tssphhhphh..t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2236	4510	6175
+692	PF00814	Peptidase_M22	Glycoprotease; 	Glycoprotease family	Bateman A	anon	Pfam-B_1670 (release 2.1) & Pfam-B_4550 (Release 7.5)	Family	The Peptidase M22 proteins are part of the HSP70-actin superfamily ([1]). The region represented here is an insert into the fold and is not found in the rest of the family (beyond the Peptidase M22 family). Included in this family are the Rhizobial NodU proteins and the HypF regulator. This region also contains the histidine dyad believed to coordinate the metal ion and hence provide catalytic activity. Interestingly the histidines are not well conserved, and there is a lack of experimental  evidence to support peptidase activity as a general  property of this family. There also appear to be instances of this domain outside of the HSP70-actin superfamily (e.g. Swiss:Q9ZM49).	24.80	24.80	24.80	24.80	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.90	0.70	-4.90	113	9668	2012-10-02 23:34:14	2003-04-07 12:59:11	20	26	4927	28	2530	7185	5233	230.60	26	77.47	CHANGED	plluphhhspht.h.....G.GlhPp.suRpHtcplhshlcpsLpcu...slshp..-lDsIAsopGPGhhsuLhVGsshA+uLAhuhshP.lluVsHlpuHhhsshht..tt........P.........lsLllSGG+oplhhspt..tpYchhGpol........DsAsG-shD+su+hlshsh.......s..uu...tlcphu..tu.......hp..hs.s.h............hshSFS....Glcosshpth............................slshuhpcsshshLspts.cshth..........hssppl..llsGG..VuuNptL+p.......tht.hstp.....t.h.hhhPs.t.assDNuAMIuh	...................................................................................................t..ss...RpHs.cplh.shlpps...Lp.pu......................sl..s...hp.......-l...DulAho..tGP.....G.........h.....s.uL.h.l...G.lssA...+u.LA..........h.u....h....s....lP..lluVsplt....uhh.h...ss.hhp.....ps....................t.P........lslll....s....u....t....+......s....p........lh...h...s.........................p.....a.....p....h.....h....u..p.s..h...........css..h.u.-..s....h..s..phuchh.th..............................................tt........t............................................................................................thsas....G..h.s.h...h...................................................................................................h...t....h.............................................................................h...h..........................................................................................................................................................................................................................................	0	882	1633	2143
+693	PF04389	Peptidase_M28		Peptidase family M28	Bateman A	anon	Bateman A	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.54	0.71	-4.54	65	5682	2012-10-02 19:46:12	2003-04-07 12:59:11	12	79	2007	144	2682	7975	2221	184.50	20	35.77	CHANGED	phllluAHaDo.hs.................htsGAsDsuoGs...AslLElA+hls...p..t.p....pp..................slhFlhhsuEE..............pGLhG..Sctast......tph................................hppltshlNhDh...h...Gs......ss.shhhtsss.........t........................h....ltshhpps.tshh.shs.psh..sth.spoDahsFh..ttulPul...phtsst..................hsttY.HospDshsp..lshsuh.p	..................................................hllluuHhDohs.........................................................hssG.A..s....D............s..uoGs..............uslL.E....lA.+....h....lt......p.........t..hp.........pp..................................................................................................slhFhh...as...u.EE............................................................................tG.L..h.G.....Sp..tasp.......t..tpt................................................................................................................t.p.p.h..h...h.hlNh....D.h.....h.........us.............sst.t.h..h..h.t.sss.....................t..t.....................................................................hpth..h.p..p.h...h.................h.....h......p.........t.....h.......s......h.......p......h...............................t...t......h......h....s.....p....o......D..a...h...sFh..............ptG.l...P..s..h....th.htss...............................................................s...ha...H...s...t...Dsh.pt.ls.....h................................................................................................................................................................................................................................	0	912	1571	2227
+694	PF01551	Peptidase_M23	Peptidase_M37;	Peptidase family M23	Bateman A	anon	Pfam-B_291 (release 4.0)	Family	Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins.  LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.32	0.72	-3.94	276	16518	2012-10-02 20:27:15	2003-04-07 12:59:11	17	180	4065	22	3908	13013	6175	97.80	32	25.05	CHANGED	phHp...GlDl....uus.....h..Go........s..VhAsssGpV..hhuuh.....t.....uh.GphlhlcH...ssu..hhohYuH..hsp.hh..Vc..tGppVppGphIGtsG.sTG..............uo...GP............HLHF.El..p.h............su.pslsP	..........................................................................t..HpGlDh...........us.s..............t...G.s................s....l..h..A..s.s.s....GpV.........sh.ss........tt.......................................ua..Gp.h.l..hlcH...................sss....hhohYuH........h..sp..hh.................Vp.................G.p.p...V....p.t.Gph..I..uhsG..soG.....................uo..........us...........................HLHF.El..p..h.............ps..p.lsP...................................................	0	1317	2602	3339
+695	PF01434	Peptidase_M41		Peptidase family M41	Bateman A	anon	Swiss-Prot	Family	\N	20.60	20.60	20.60	20.60	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.37	0.70	-4.86	31	7039	2012-10-03 04:41:15	2003-04-07 12:59:11	13	33	4736	42	2254	5669	3966	203.00	39	31.13	CHANGED	ohp-l--AlDRlluGhE++.shllopcpK+llAYHEuGHAllGhhhcssDPVpKVTIlPRGp.AhGhThhlPc-Dph....ho+ppLhsplssshGGRsAEEllFG..clTTGAusDlppsTplARpMVTcaGMScclGslshtppss.t..hh.tht.tptaScpTuphIDpEV+pllccuYc+ApplLpcp+ctl-tlActLL-+ETlcu--hppl	.........................................................p..p-h-cAhD.+l.l....h..G.sE.+.+..o.t..l........h..o......ccE+..c...............hsAYHEuGHAll....uh.....h............l.....s.....p.....s............-......P.....V.........p..K.......V.....T......I.....l....P....R....Gp.....A.......L.......Gh......s...h..h...L..P.........c.....c..D..phh........ho+............p..p...........L.hs...............p.ls.shhGGRsAEEllaG.................cloT.....G....A....S....N....DlcpATp....l.AR.sMV.....Tp........a...G..M.....S...-..c..l.G..sl...ta...s.p.p.......ps...........................a.....h...h...t.....s.......h......t.................t.........p.......p.................s.hS-...p...TA..p...h.ID.pEV....+pll..ccsYpcApplLp.....c..pc................-t.lc...............tluctLlc..hETlsucplppl..................................................................	0	790	1454	1932
+696	PF02163	Peptidase_M50		Peptidase family M50	Bateman A	anon	IPR001193	Family	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null --hand HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.09	0.71	-5.34	68	8451	2012-10-03 04:41:15	2003-04-07 12:59:11	17	49	4572	15	2487	6748	4385	283.10	20	78.45	CHANGED	hhllulhlhls.lHEhGHhhsA..+ptGl.plpphthhhG.hlhthh.ht.h.h............................................................................................................hssshphphtptshhp+hhlshAGPhsNhllA.llhhhlhhhhss...............................................................................................................................................................................................................................................................................................................................................................................................................h.............htsshhthhhhhuhlslsLulhNLlPlssLDGG+llh.hh.............hh.tt.hs.phtthhhhhshslhhhhhhhshhps	.......................................................................................................................................................................................................................................................................................hhlslhlhlh....lHE.hGHhh.sA......+h.h.Gh..pst.ph..t......h..t..h..........u..................l.......ht..h............h............................h.............h........h......t.h.h............h.....h....h.h.....h............h....h.s................................................................................................................................................................t...........t..h..t....h..tp..ps.hh.p.+.h..hl.hhA..GPhh.N..hl...l.u.l...l...h...h...h...h....h....h....h...h...t.s...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.t...s...h...h........h.l..h......h....h....u....h....l....s.l.s..L....u.l.hN....L....l.P.......l.....P.....s....L....D.GG+llhhh.h.........................t.h.h.h.....t.p..........h.............p.....h...t..t..h..h....h...h..h.s.h.hhh..hhh.hhh............................................................................................................................................................................................................................................................................................................................................................................................................................	1	901	1712	2148
+697	PF02897	Peptidase_S9_N		Prolyl oligopeptidase, N-terminal beta-propeller domain	Griffiths-Jones SR	anon	Structural domain	Domain	This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see Pfam:PF00326), excluding larger peptides and proteins from proteolysis in the cytosol.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.28	0.70	-5.90	30	3044	2012-10-05 17:30:42	2003-04-07 12:59:11	10	23	1955	38	1041	2696	2777	371.10	22	55.84	CHANGED	Psst+spttspph+Gpp......lsDPYtWLEDsc.....us-spAaVcApNphTpshLsph.sh+stltcclpphhshs+hosPa+cGpaaYYh+NsshpspsVlhppsss......pups.............cVhLDPNsLSc-G...TsulpshuhSpDGchlAYulstuGoDhhsI+hhclcsu..........................c.lsDsLcpVKaos.lsWssDscGhFYssaspspcsp.......pths.ppKlaaHtLGTsQSpDh.LlaEts-psp.hhhusplScDG+Ylllustpuss..NclahtDlppp..........s.hhphhhllsphcuphthVspc.......GsphhhhTN......csuPNh+LlssshssPs..pWcs.......lls-+ccclhh.shsltusaLllsYhc-spsplphachs............sthhhcphhhslGolsuhuuppcssclaapFoSahoPsslYch-hssschchhphp	.........................................................................................................................................................................thaG.t......h.Ds.YhW.........Lc....D......s............ssc.shsa....l.p.tcNths.p...t.h.h......s..p.........................s....hp........cp.lhpch....t...s...........h...h..p...t...p..c....h...u.s.....P....h..........h....c....s...s........a..h.Y...h.th.h.p.s.....s...p..p...sl.h..hRpssh.............tt.t......................................cllL.....D...s.....Np.....h....u.......t...s...p..........t.....ah.h.....h...t...uh....s....l..........o.......s.....D....s.......p.......h..h......A.........hu.........hs...h.t.Gs.-hh.s.....l.+hhclp.o.s..........................................................ph.h..s...-.....h.....l....p.....t....s.p....s..s..........hsW....s...s.D.....s....p....s......h..a.Ysp...hct..t................................................sh.pl.a.h..H..pl.......G.....o....s...ts...p......D........h...ll....ac.c.....p.....-.....s.....s.....h...............hh........u......h.......t......t........o..p.....s......p...c.......a...........l..h.......l..p..h.s...s...tss.........s.c.l...hh..lchpt...................................tsp..hhl..h..s.c.pc....s.h...th...l..sph...........tp.p...h..a..l.....hoN.............pp.u...s..h...t...l...h....p...s.....t.....h....p....s.......t............p.hp.......................lh..cpt.h.....h.....l.....p......s..h.......s.h......h........p..s.......a.l.....l.lp...h.pp.s.hs.pl.ph..hshp..............................................tth...hh.p.........h.......s...h......h......................h....s.....h....s.......s.....c...........c.....s.....sp...lh.hsa..oShssPs..plachsht.s.t.p.phh...t...................................................................................................................................	0	356	649	859
+698	PF04080	Per1		Per1-like 	Wood V, Finn RD	anon	Pfam-B_12918 (release 7.3);	Family	PER1 is required for GPI-phospholipase A2 activity and is involved in lipid remodelling of GPI-anchored proteins [2].	21.50	21.50	22.40	28.50	20.40	21.30	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.05	0.70	-4.97	34	346	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	246	0	231	344	0	246.10	35	77.58	CHANGED	pp.P..lhh+hhhWsC.u-CcYp.Cp..phhTppRhpp.s.....tls............................................QFHGKWPFhRl.....hGhQE.hSslFSlhNhhspap.Gh.tphpc.pl.pp.shpph...........alhhuhluhsAWhaSslFHsRDhslTE+LDYFsAuusVLhuhahshhRhhpL......pp.thtthasssslsh.assHlhhL.hhcaDYsYNMtsNlshGllQhllWhhauhhphpphtp.......................................................aslhPhllllhshhuhuLElaDFPPhhh.hlDAHuLWHhsTIs.shh.WYsFhlpDhp	..............................................s...PlhhphhhWsC.s-CcYp.C...hhhspthhpp..s.......ls............................................QFHG.KWPFhRh....................hGhQEPhSslFShhNhhsphh.sh.hphhp....l..tp...sht.h............................................ahhauhluhsuWhaSslFHoR.DhslTE..+LDYasAs.uhllau...lahshlRhhpl................................pp.thhhhhs..sh....hlhh.hssHlh.YL......p..h.h.caDYsYNMtsNlshGllphlhWhhash....h..ph....pth............................................................hphh..hllhhhhhuh.LElhDFPPh....hh...hlDAHulWHhsTls.shl.aa.sFlhcD...........................................	0	71	128	191
+699	PF04695	Pex14_N		Peroxisomal membrane anchor protein (Pex14p) conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4121 (release 7.5)	Family	Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes.  Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein [1,2].	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.94	0.71	-4.12	53	413	2009-09-11 00:50:26	2003-04-07 12:59:11	8	13	263	4	278	398	0	121.40	28	31.63	CHANGED	sRc-LlssAlpFLpDssVpsoP.lp+KlpFLcSKGLop-EIctALpcussss.....................sspshsssssssshtssssss............hp............................sss.....................................sW+DhhlhssshuGlsauhYthsc+YlhPhl	............................R-pllpsAlp........FLp.......csp........VpsuP.ltp+hsFLcsK.....GLTp-EI-tAhpc....sssss.........................................st...ss.....s......ts..s..s......................h..............................................ss.......................................sacchhhhs.hhhuGluhuha.hh+phlhPhl...................................................................................................................	0	88	153	229
+700	PF00294	PfkB	pfkB; 	pfkB family carbohydrate kinase	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This family includes a variety of carbohydrate and pyrimidine kinases.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.75	0.70	-5.29	64	26513	2012-10-03 06:25:16	2003-04-07 12:59:11	19	81	4887	268	6104	23264	9854	285.90	18	86.51	CHANGED	hstlsslGts...h-hhhhs.t..........thh.pstphphtsGGsutNsAhslupLG....hpsshlutlGsDphGphhhptlpppslssshhhhssp.pposhshhhhsts...ppslhhhhssssphpht...........hltpsphlhluu.....hhsts....tshhpthtphtcpts....s.shhsshht......hhpthpchh.shssllhsNccEhphhhstp...........shpphhphhtp....th...phlllThGs....cGshhhp.................pstththssh...thplVDTs..GAGDuFsuuhlsslhp..........stslccslphusssuuhslpptGsts.s.h..ph	...........................................................................................................................................................................................h......hG.h....hp..h.........t.................t....tstp.h.p.h..t.s.GGsuhNhA.hs.h.u.p.LG...............................tpst...h...l..u.h...l...G.............s..............D........t...h..G.p........h..l.h..p.t....l..p.....p........t..........u....l.........s.....s............s..h.....l.....h...h.........t.....s......p.....t..........t.......o.........u........h...t......h...h..h....h......s.....tp....t...........p......p........p......h.......h....h.............t....s.........s....s..s...p..h..p....t..................................t..h.l...t...p......s...c........h....l..h...hsu.........................h.......t.h...s...........p...h..h...p...t...h.........h.....p....h..t..p.pt.s..................s.s..h.h.s.....s..hht.........................t.h.....h...t.....p...h....l....tt.s....s...........l........l...h...s.........N..c......p..........E..h....p..h..l..h.u.hp......................................................s.pp..h..h..p..t..h...p...t......................ss...........ptl..l.....l.....o.....h........Gs....................cG......s...h...hhp...........................................................tst...h.h..p..h..ss.............t........s..p...l....l......D.......o...s...........GA...G......Duah.uu.h.l.t..u.l.hp.................................s.t..s..h..t..c.u...h...p...hA....ss...s....u......uhslpphGs.........t..........................................................................................................................................................	0	1886	3711	5053
+701	PF00169	PH		PH domain	SMART	anon	SMART	Domain	PH stands for pleckstrin homology.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.45	0.72	-3.82	133	16347	2012-10-04 00:02:24	2003-04-07 12:59:11	24	818	416	205	9216	15741	151	107.30	17	13.94	CHANGED	hhtpGhLhpps.........................ttppacc+ahhLps.......stLhhacspp....................................................................ttp.pttlsLpsh.plppssst.............................................................................ppptsFplttspp........................tphhlpssop.p-tppWlpslppshp	...................................................................................................................................h..hpGaLh+ps...................................hhps..W..c.c......Ra.hl..L..ps.........................st.Lh..a.acsp.p..................................................................................................................................................pp.p.s..p.s...t...l....s.L....p.....s.h....p....lptsspt....................................................................................................................................................................................................ppphs......F.p...lhstpp.................................................sh.hl...p.....A.....p..o...p..p-....h..p..pWlpslpp...t................................................................................................................................................................	0	2389	3501	5912
+702	PF05065	Phage_capsid		Phage capsid family 	Finn RD, Bateman A	anon	Pfam-B_3186 (release 7.7) & Pfam-B_9481 (release 10.0)	Family	Family of bacteriophage hypothetical proteins and capsid proteins. 	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.98	0.70	-5.21	189	3200	2012-10-03 06:22:39	2003-04-07 12:59:11	8	11	2039	63	462	2535	684	261.30	16	68.16	CHANGED	GGhllPpph.tsplhpthpptss.lpplssshs..ss.ssphph.hspss..............tushhu.....E...............tt.....spsss..phs.plsh...sscclsshh.tloppl..LpDushs..lp.sh...lssc....lspthutpcstshltG......ss...pstGhh......................hthssh...sssst..............h..............-slh....phh..slpsshp...t.ss....alhspssh.stlc..phK...D.ssGp....hlht...ssh...tssts......plhG....hPlhhspsh.............t.....................lhhG.Da....pshhlsc.....cts.lpl..hps......................s..ppshsthhshpRhssslhc..s.pAhth.hph	..................................................................................................................................hlstph..ppl.hp.hpppss..lt..p..hsphhp....ss..tt..phph...httts......................sushss.........E................................sp.....spsps....phs.pl..sh...sh.t.c.l......s.s.hh..tlo.p.c.l....lcsu..s....hs.............lt.sh........ltst..lsps...hstt..cp...sh....lpG.......................ss.....p.....shGhh...................................................thssh.....ssss.................s...sh..................................................................................cslh................shh.t....tlps.shp..............t.su........hlhssssh...ttlp...phc........s..ssGp......hlh...............s.h............ttsts.....plhG...........hslhhspth.........................................................................thhhG..sh....pthhl.sp.........pts..hphth.pp..........................tps.hh.hhstth..hshthhp...pAhhhh........................................................................................................................................	0	140	299	389
+703	PF02899	Phage_int_SAM_1	Phage_integr_N;	Phage integrase, N-terminal SAM-like domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.78	0.72	-3.83	37	10422	2012-10-02 14:21:04	2003-04-07 12:59:11	12	29	4035	13	2334	8796	3027	83.20	22	26.81	CHANGED	lcp..ahpaLthc+shStpTlpuYppsLpthhpahpp....thtshppl...stpcl...p.talschtpts........hsssolsp..tluulRsaapa..hhpcs	...........................................pt.ah.ph.L..h..h.c...+..s..h..S..tpTlp.uYppDL.........pp.hh..p..a..........lpp.................th.....h.....s.......h...p.....p..l...................stpsl.....................p.sa.l.s.p....h.tpps................................hsssohsR......ploulRs.Fa.p.a.Lhpp................................................................	0	747	1479	1975
+704	PF04860	Phage_portal		Phage portal protein	Kerrison ND	anon	Pfam-B_6050 (release 7.6)	Family	Bacteriophage portal proteins form a dodecamer and is located at a  five-fold vertex of the viral capsid.  The portal complex forms a channel through which the viral DNA is packaged into the capsid, and exits during  infection.  The portal protein is though to rotate during DNA packaging  [1]. Portal proteins from different phage show little sequence homology, so  this family does not represent all portal proteins.	27.90	27.90	27.90	28.20	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.93	0.70	-5.78	127	3192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	1991	3	469	2728	646	315.20	19	80.95	CHANGED	ht.st..ssh..tls.tpsshp.tssla..uslph.lupsluphPltlhcp....t.ttp.h.t....pslhpllp...pPN........ouhpahpthhhphlltG.Nua.shhhh..s......s.up..hh...p...Lh.lpspp.h.................ht..ss....phh.Yphp...........ss......tt...t.phstscllHl+.h..hshs.....shhGluslp.sutpslslshusppastphapNGspsuullphs..sth....sp..-phcp....hccphpp.thpGsssss...pshlLps...............G.hcapsl.....shssp-sphlp.s+phshc-IuphatVPsthluthtp.soh..usl-ptshsahphsLhPhlpphcpplstpLh..t.tthttthhhcFshpsllcs-.tsphphhtphhpsu....hho.N.EsRth.s	..................................................................................................................................................ht..........t..pshht..ssl...sslph..lupsluphshhhhcp..................................p.lhthhp....cPs...............suh.phh.pthhhp.hll..hG..Nua..l.hh...p....s..h..............t.Gp......sh.p.......Lh.h.sph.s................htstst.......................phh..Ythp............................................ts...................pt.......thpht.p....cl.lH.lp.s......h.p......tl.h.G.....hsshh.sshpsht.hstusppaptphapNG.u.p.suh.ll.h........stl....................sp...cshpp.........l+pphpp..t...p.G.....t..stt....+shhlps.....................G.h..chpsl.......s...ss..tc.sph.hp...hcphs...tc...c...ls....t....saplPst.hl.u...hh..s..p...ss...........uslEptst.sahpt.sl.hP.hhp.phpptlsp.hLh..................t.......hhcFs....sh..h..ths....t.ht.....h....hht..s.......hhs.s-hR.......................................................................................	0	123	284	381
+705	PF05119	Terminase_4	Phage_sml_term; 	Phage terminase, small subunit	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	24.20	24.20	24.20	24.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.00	0.72	-3.85	76	1248	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	969	0	185	864	92	98.70	21	66.43	CHANGED	A+ppW++lss.LpchtlLsphDhssLttYCpsYupahpspcplpc........pGhh.........hpstsG................thppsPhl.shhpcshpphpphusphGLoPuuRs+lsh....spspcscs	.............................tt.apchh..L.p.p..h..sh.lsthDh.thlptY...spsashapps...pcplpp.........pGhh................hpspsG...........................shtps.Phl.shtpcshpphpphssphGLossuRt+lhh.....tttt...s...........................................................................	0	56	117	162
+706	PF03354	Terminase_1	Phage_terminase; 	Phage Terminase 	Finn RD, Mifsud W	anon	Pfam-B_3931 (release 6.5)	Family	The majority of the members of this family are bacteriophage proteins, several of which are thought to be terminase large subunit proteins. There are also a number of bacterial proteins of unknown function.	19.70	19.70	19.70	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.45	0.70	-6.08	7	2382	2012-10-05 12:31:07	2003-04-07 12:59:11	10	9	1576	0	301	2092	481	410.10	22	80.19	CHANGED	PaQcFhhs.haGW....cptsss+pFscshhpluRtpGKohhhAhhslhphhlt..GpsstphhlsuhshcQAtclF...............p.stp.h+t....p..hphh.c.cl.tsppptl.hhh.pshh+hhospssphDGhp.phsIhDEhtphpscphspplhpG.ht..tN..hlhI.oTussshsu.hc-chchhpphh....phpsDsaashlap.Ds.--shDsppWhKuNPhLshs.phcslhcshptstsssh....phscFhsKphNLWh.pcossahshpsh-p......hs.hshpG+csalGlDhShhsDsTAlshla.htG.....+hahcshoFhP.tsttt...t..pptt....pYpphhppG...hphpssuhIs.pplhshlhpahppp.hplpthuYD...shtsp.hhsplppp.hsh...shhclpQshtshusshKhlpphhhpp+lp+sss.lhphtlhNsshKhDshs.lphsKcts...stKIDsssAlI.AhhpAhhst.	...................................................................................................................................................................................................................ap..h.hhst...la.G...h...................t.p.t.....s..t.h....+h.a..p..c..shl.l.sR+sGKo.t.lh.u.sl.h.h.h.hh..h.hp..................sp.....s.t...c...l...h...h.s...AsspcQAphs.F....................p.s....pp..h.l.pt.................s...h.p.........h................p....h......................t.....p..p...l.........h.........h........t...s....t..u.....h..hp..h.....h..s....s....s.s.p.s.h.cGh.p.s.t..h...slhDE......h....+....t..h......t.........s.........p..........p.......hh...p....s....h....ps....Ghut...p...ps......h..hhh.I...oT..u..G.....s.....h.p..u....h.h.p...h.h.p.h.s.t.......p.......l...l......p..........t...................................p..........h..............ps..............s.....p.ha.s...h.l......h.....p..........h......-...........c.................t..........c................-.............h..p.......c.......p.s......W....h.....+.AN.....P....t.l.....s......h...s...h....t........h......c.t.l...h....pp.hpp...s.p...p...s.st................th.tt...a...hsKphN..h..h..h......t..t..p....t....s.ah.sh.....pph...pt................h....h...s..............p......h.......p....s.....p............s..h....h.........G.l.Dh....up.hpDhs..u..h..s..h...h..h...........p.s...................ph..h.h..h.s.h.....a.h.s..pt...h.p.................pp.p.............apt...a....c.......t.G.......h...lph.s.t...s...s...h...l.c......ht...lh.p......hhh.....p...hhpp.........................h....l..p..t..l.shD....h.ts.t.t.h.h.pt..l.p..p...s.h.............................hh.th.Qs...........h........p...................h......sss........h...c...p...hcphh...............h.............pt..p..........l..ha.s..s...........sPlhpWhhs..Ns..hh.c......c......s.s.s......h...h...sK...p.p.p....p.pK.IDshhAhl.Ah........th.......................................................................................................	2	82	188	254
+707	PF00628	PHD		PHD-finger	Pascual J, Bateman A	anon	Prosite	Domain	PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2].  Several PHD fingers have been identified as binding modules of methylated histone H3 [3].	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.96	0.72	-4.27	92	10006	2012-10-03 17:27:21	2003-04-07 12:59:11	24	581	416	151	6059	10034	80	49.80	31	6.20	CHANGED	hC.lCpp.............ssphltC..-..s.Cs.psaHhtCls.shp..ph.pt.........tWhCspCpsp	...........................hC.lCpp................tt....ssp..hltC....D............p..C...s...phaHh..tC...ls..s...hp.........p..hsps...................pW.hC.s.p.Cp..t..............	0	1693	2722	4372
+708	PF01384	PHO4		Phosphate transporter family	Bateman A	anon	Pfam-B_923 (release 3.0)	Family	This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter [1]. This family also contains the leukaemia virus receptor Swiss:Q08344.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.01	0.70	-5.78	174	5075	2009-01-15 18:05:59	2003-04-07 12:59:11	15	11	3412	0	1413	3524	1377	368.90	29	86.21	CHANGED	hGuNDsANuhuTuVuo+slohpp.AlllAulhphlG....Alhh.....GspVspTIsp.sllssshh....................................................shhuuLluuslWhhlushhGlPlSooHullGullGsulsss.....G...h........................ss...lpWs.......................................t.lhp...IlhuWllSPlluh.hluhllh...hhlphhhh..........t.h......................................hhh.........................................................................................................................................................................................................................................................................................................................................................hpph.......aphhtlhoushhuFuHGuNDsupulGslsshhh............ts.h...................................................................................................................................................................P.................h..Wl......llhuuhululGhhhhGh+llcTlGpcloc..lssspGassphuuAhslhhAoh.........hGl......PVSoT+slsGulhGlGhsc..............................................................................................t.hp..slph...phltpIlhu..............................................WllTlPh.....uullu	.............................................................................................................................................................................................................................sGhpDsANuhATslu...............o+ulp.s.ph.Al.lhAulhshhG...........shlh..............G..s...p.VutT.Itp.sl...s.s.s...hhs.................................................................h.hhhh.usLlu..AhlW..lhshhhGlPsSoo..Hu.....lIGullGsulssu.............u....h..............................................su.lshs..............................................................t.lhp.........I.hh.........uhllSPll.uh.l...hu.hll.h....hllcthh.h.................th..............p.h..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pspph.........ap.hh..l.hoA.shh...uFuHG...uNDsppuhGhlh.hllh...............ht......ssh..........t..................................................................................................................................................................t..sP............h..Wl..h..hh.sululu.lGshhh..G..h+lhpTl.GpcIsc..ls.s...p..G.huAphsuAhs.l.h.h.Ao.h...............h.G....h...............PVSTTHsls.uulhGsGhsc..............................................................................................t....t....ulph.....tssppllhuWllTlPsuullu...........................................................................................................................................................................................................................................	0	437	853	1191
+709	PF01663	Phosphodiest		Type I phosphodiesterase / nucleotide pyrophosphatase	Bashton M, Bateman A	anon	Pfam-B_994 (release 4.1) & Pfam-B_6150 (Release 8.0)	Family	This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD,  deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which  exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form  F. odoratum [2].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.38	0.70	-5.13	70	4764	2012-10-03 20:55:17	2003-04-07 12:59:11	17	83	2021	34	2144	12839	5667	283.30	14	54.15	CHANGED	llllulDGhpschlpc.........tthPslppL.........hppGspst..hpssaPohThPsahollTGhhPspHGIluNphhD...........................................sppptp..athp.....shpsh............PlWhssp.cpshp..........sushhaPuspsshss......................Pphh..phhstp...hsh......................................................ptchsphhp.hhch..pscc........sslhhhah....ppsDpsG.H......................paGs..s..usc........hpp......slpclDphlupLhpsLccpth.tpssl.lllS.........DHGhsss....................................p+hlh...........lsph...........hs.sth...............hspsslstlhsp.............................ttthsclhptLpsh...........tthpshh...cp...phs.tchpht..........................spRhsslhlhscsGhhhhtpt................ttph..thtGsHGac	.............................................................................................................................................................................................................................................................................lhh.hD..u....h..t......t....h.....................h.s.h..t.t..h...............................h.p.p..u.h....h...............h..............s...............h..........P..........o.h..o...h..s.s...h..s.lh....T..G......h..h...........s...t.........p....G......l...h..t..........h.h.......................................................................................................................................h...............................................................................shh....t...t...................................ss........h..............................h.......t....................................................................................................................................................................s........h........................pt............h...................................................................................................................................................................................t.h..s...p....h..h............h.h.t...t.......h.....t...p.pp...................................s..h.h..h...h........a.h...........................t.h.......D....p....h.G...H.......................................................................................................................th.Gs.......p..........u.p....................................................htp.............................tlp.p.h...D.p...h...l...t....p.l....h......p........t.l.....p........p...t.............................t......h.......l.ll.su................D.....H...G..hssh......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	703	1239	1744
+710	PF02811	PHP	PHP_C; 	PHP domain	L Aravind, Bateman A	anon	L Aravind	Family	The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null --hand HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.25	0.71	-4.48	69	14520	2012-10-03 00:45:34	2003-04-07 12:59:11	14	119	4828	48	3478	11535	3589	213.50	16	29.40	CHANGED	h-LHsHopaS.......DGts.slc-hl...cpAtchGhp....slulTDH..sshhs...shphhpttpt..............................hs....lp....hlh..GhEhpls.t.....................................................................................................................................................................................................tpt....htt.hchhlhuh.pt................................plsphtshthh.................................phlpph......ppshlslhuahpsththh...............hppscphlpth...................................ht.pshhhElpspth.t.......................phpp	................................................................................................................................cLHsH.o.....s.h.S....................DG....h.......h....s...h.......p.....c.....hl..............pp.At.p.h..Gh.p....slAlTDH.................ssh...h.u.................h.s..c.h...h..pt.spt........................................................................................ts......lc........hlh....GhEhthh.................................................................................................................................................................................................................................................................................................................................................................................................................p...t.tt...h...c..h.h.l....h.u..h...p...p......s.ht..................................................................................slhp.hhs.t.t.hh.........................................................................h............phlt.th..................ppG.h.l.h.hh...u...p........t...t.......h...h...h.............................................................h...t.hht.h..............................................hhpl..................tthtth...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1312	2409	3037
+712	PF02972	Phycoerythr_ab	phycoerythr_ab; 	Phycoerythrin, alpha/beta chain	Griffiths-Jones SR	anon	Structural domain	Family	This family represents the non-globular alpha and beta chain components of phycoerythrin.  The structure is a long beta-hairpin and a single alpha-helix.	22.50	22.50	23.60	53.00	20.80	17.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.77	0.72	-4.37	5	25	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	4	6	0	31	0	56.60	54	46.87	CHANGED	+APVITIFDHRGC.SRAPKEYTGsKAGGpDDEMCVKVuMsKlpV...SEusAstlLpEhLu	.+APlITIFDHRGC..uRAsKEYTGuKAGspDDEMhVKVtusKlpV...SpusAsthLpphlu...............	0	0	0	0
+713	PF05023	Phytochelatin		Phytochelatin synthase	Wood V, Rawlings ND	anon	Pfam-B_9299 (release 7.6)	Domain	Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols [2]. The crystal structure of a member of this family shows it to possess a papain fold [3]. The enzyme catalyses the deglycination of a GSH donor molecule [3]. The enzyme contains a catalytic triad of cysteine, histidine and aspartate residues.	23.80	23.80	23.80	24.00	23.40	23.70	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.33	0.70	-5.37	20	280	2012-10-10 12:56:15	2003-04-07 12:59:11	9	7	183	4	123	295	16	197.80	39	55.01	CHANGED	shsuhhppsLPs.shlsFuSsEGccLhtcu...ushcsaasLtspF.TQspsAaCGlASLsMVLNALu...............lD....PscthcG.PaRaFopssl.......pspshtc........lpcpGlTLsclusLu+sp..usslcsa...........................+us.chSlspFRpplhpshsssspalIlsYpRpslsQTGsGHFSPlGGYcttpDhsLILDVARaKYPPaWVshphLapAMpolDs.soucsRGahLIs	..................................................................................................................h......h.lst..hlthsS.tGpphh.pu.......sthpsaapLhs.tFpTQspsuaCGlAoL..........shVLNALt................................l-.....Ps..cta.c..u...PW..RaFspshLt..............sspshpt............lcp.pGlohsc....lssLApss........Gspspsh...................................+ss..ps.o...l.-pFRphlhp......s..s................s.......s..s.........s..........p.alllsYpR.ps.....l.t.......Qs...G..............s....G...H....F............SPlGuYcttp.D............hsLILDVARaK.YPPaW.Vsh.phLacAMso.hD.t..so.s.ptRGahll.........................................................	0	64	91	107
+714	PF02567	PhzC-PhzF		Phenazine biosynthesis-like protein	Mian N, Bateman A	anon	COGs	Family	PhzC/PhzF is involved in dimerisation of two 2,3-dihydro-3-oxo-anthranilic acid molecules to create PCA by P. fluorescens [1]. This family also contains Swiss:P28176, though there is no significant sequence similarity to Pfam:PF00303 members. This family appears to be distantly related to Pfam:PF01678, including containing a weak internal duplication.  However members of this family do not contain the conserved cysteines that are hypothesised to be active site residues (Bateman A pers obs).	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.87	0.70	-5.19	14	3486	2012-10-03 03:02:41	2003-04-07 12:59:11	11	19	2256	24	972	3693	843	247.90	26	93.31	CHANGED	lDAFTspPhp.GNPsuVsh.s-.....pls-stMQplAsEhshSETsFlhhss........pssch+lRhFTPssElshsGHuTluouhsLhppsh......ssspl.hpThuGhlss.............tppssstphhlphphPhhshhshsptt.s.h.hhhths................sh.hthtssGhtplhlsLpShculsslpPch........p.htchsstuhhshsstsssustcapuRhFu.PthGlsEDPsTGSAsssLutYLspchph.......phplhQGpu.uRsGplphph.....c.t...p+VplsGpAVslhcG	......................................................................................................................................................lDsF..o..s.p..s...ht..GNs.su.Vlh...sp...................L..s...c.t.p.MQtI...A.....p.-...h.....s....h......S........ET......s......F..lh..t.s..................................t.ss....sh......c.....l..Rh..F.T.P.p.t.E.lsh.sGH.sTlusu.h.s.lh..phht......................tssp.l...hh.ps.t.u.G..h..ltl.....................................................t....t..t.th..h..h.p......s....h....P...t...h.......t...s................h.......s.....t....t....t.....h....t...h....h.......t..h.h.h..p...................................h..s.t.h.h.s..s.G.......t...t..l..h..l.......l.p.....s....t...t....s...l..t......s..l.....p....P.sh..................................th.h..t...p...h.....s....t....t......s.....h.....h...s........h......h..........h........t.......s......s........t.......s.......t....t....c...........h..hu..Rh.F..s...P..t..h.G..l......s....EDPsTG.oAsus..l..u.s.a..hh.p...p..h.hh...................................h.p.h..pQ.G.p..t.h.s..Rsu..hlt.splt.............................tp........l...h...lu.....Gpuhhh.......................................................................................................................................................................	0	306	597	824
+715	PF00454	PI3_PI4_kinase		Phosphatidylinositol 3- and 4-kinase	Sonnhammer ELL, Finn RD	anon	Prosite & Pfam-B_6771 (Rlease 7.6)	Family	Some members of this family probably do not have lipid kinase activity and are protein kinases, e.g. Swiss:P42345 [1].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.34	0.70	-4.90	43	4451	2009-09-16 22:35:53	2003-04-07 12:59:11	22	163	790	95	2750	4248	185	225.50	21	15.05	CHANGED	th..hhhKsG-DLR..QDthhhQhl...........................plhsplhpp-shshc.......lpsYtllshusptGhlp..................hlsss.ohtpl..tpthhptth................................................................sslhphFhcpssss.......tpahp................................................................stppaspShAshsllsYlLGluDRHssNlhl......................................ptsGclhHID.................FGhhhs.....t..p.-psPFcLop........shspsh.t.....ssstphthF+phshpshphlRcstshlhsll.........phhhpsslhphpp	.....................................................................................................................................................................................t...hhhK..s..t.-..DhR.....pD.hhhQhh.........................................................phhp.pl..h....t.....p.p..s.h.s.hp............................htsY..t...llsh...us...t............G.......hlp........................................hls.ss.....sl..t........t....l............p..p..h.....h............................................................................................................................................................ssh.hph..h...h..p...p.....s..ss.............pt..a..h..p..............................................................................................................................................................t.pp..p..a...spS.........h....Ashsl.............lsYl.....Ls....ls...D.....R....H.ss..Nlhl.......................................................................................................ptsGc....l....hH....ID.................................................FGh.h..hs..............t...........t.....-ps.PF+LTp........................phhpsh.......................t.st......th..a..........p............p.......h..........s................p..........sh.......h...hR..p...p...t..p..h..lhsl.h.................phhh.ssh.t...t.........................................................................	0	1017	1545	2244
+716	PF00792	PI3K_C2		Phosphoinositide 3-kinase C2	SMART, Griffiths-Jones SR	anon	Alignment kindly provided by SMART	Domain	Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family. 	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.78	0.71	-4.41	24	929	2012-10-10 12:23:49	2003-04-07 12:59:11	19	41	276	79	559	820	7	139.70	21	12.87	CHANGED	sp.plhlpssla...tssc.Ls.....sl.poshsshs..........phsWs.chlsas.lphpsLPtsAhLslsla.....shptsppt....................lGhssl.LFsp.+shL+p.G.ppLpl.Wsstpsst.h.h.......................thppGphpp...sphlDthsh	..............................................................s..clhVpstla..pss.c..Ls........sl...pTphhshs.......................tphtWs..c.....h..lpa.s..lplscLP+pupLslsl.a...........s.l..stspst.......................................................hsluh......sslsLFs........h...cshL+p.G.phtLpl.Wssstsptt..........................................................................t....................................................................................................	0	172	248	399
+717	PF00640	PID		Phosphotyrosine interaction domain (PTB/PID)	Bateman A	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.75	0.71	-4.20	25	2909	2012-10-04 00:02:25	2003-04-07 12:59:11	18	102	112	50	1457	2821	2	128.10	21	22.94	CHANGED	Fts+YLGsl-Vsps......t..h..sp-Alpplptt.................ht....h..puptpph.pplhLplSscslplhssco.........ppllhsaslcpISahus..Dss.p.ctFua...............htctsspphtCHlFhspc....ApslupulGpAFpltapphLct	......................................................................................a.spaLG.hpl.p...............s.ppulpplptt.............................................st.t.p...ph...hpl.....h...L...p...l...o...h.p...s...lp...l..l...s..sps.......................pp..l.l...h..p..p..sl.p.p..I.Sa.h.ut........D...............p..p...............chFua..............................................................hs.p...c...t....s...s....p...p....hhCH..lFp..spp.............Aptl..s.s.ltpAF..p.hthp.h...t.............................................	0	345	463	898
+718	PF04987	PigN		Phosphatidylinositolglycan class N (PIG-N)	Moxon SJ	anon	Pfam-B_5307 (release 7.6)	Family	Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum [1]. PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localised proteins that serve many important cellular functions [2].	20.80	20.80	20.90	20.90	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.54	0.70	-5.83	39	370	2009-01-15 18:05:59	2003-04-07 12:59:11	9	19	235	0	259	348	1	374.50	26	46.08	CHANGED	cGLcYLQTYsWhaLpsllThGalGWIsashstllchash.......ptp.......p.....................pohhshhhFss.lhlsLhhlhhhQ+SPhpYYhYhhFPlhFWpp............lhscppsltsuhp.hhtt.p......hhphlhthlhh.lulhEsl..VhuaFcRplholhahhhuh.as..hhhshthht..ppthhshhWhlsslhhosFoLL....sss+hcshphI.......hhuuhLhhlsuhhhlh......................tsphoppl......hshQlhhlllshhsTptoshSLps..+pGLPhhsQlsuWhhLlsSll.lPhh....ss.schhtRLhlIFLshuPsFllLoISYEuLFYhsFshpLhtWlplEptlhh.stt.t.................................................h+slslsDhRlulhahhhlpsAFFuTGNlASlS............SFsL-SVhRllPlFsPFs.GALLl.lKLlIPahllossLGllscpLplsspslFhlllslSDlMoLpFFalV+scGS	..................................................................pGLpYhpsYshhhLhshlshualGWhhhhhhhllc.hs...............p..........p.....................................tthhhhhhhhs.hhhhlhhhhhhppsPhtaahYhhhPlh.....h.W.t.........................lhtp.ht....hh.tt....h..h......h.t...............................h.phhh.hhhh.hhh..hphl.....lhuaa.R..hhohhhhhhuh.hs...hhsh..h......tthh.............hhWhh.shhhusFsh....h....ss.h..sh.....h.l.............hhuuhlhhh.hshhhh.................................................h.thphhl.............hhhphhhlhh..shh...........sh.thpt...p.tslPhh.plhuW..hhlh.uhh...hPhh.............................s.pthhtRLh..lhhshhssallLohuYEu..LFhhhhshhhhhWlp.........lEpthh..pt.................................................................pthhhpshRhuhhhh......hhh.suFFuTGNlASls............SFshsolhphlslF.sPFhhuuLlh.hKlhlPahll....sshthl...........shh.hphs...............tsl..................a..........hhlh.......hhoDhhsLpFFahV+spGS..................................................	1	74	129	213
+719	PF01850	PIN		PIN domain	Bateman A	anon	[1]	Domain	\N	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.43	0.71	-3.78	170	8807	2012-10-03 20:43:45	2003-04-07 12:59:11	16	13	2111	52	2682	7029	1235	121.10	16	80.11	CHANGED	hhlDTslllthh............pscsttthhtthhpt........tplhhsslsh..hElhhshpp..............................tttphhphhhh.htthplls...hstphhtpstclhtpht...........lshhDshhhAtA.......httsht.....ll.T.tDpc.......htchsth	..........................................................................llDTsll.lthh...................psp...s.t.t.t.t...h....tt.h.lpt..................tplhlssh..sh...hE.lh.hshpp.............................................t.ttp.h.hthhhh.....h....t..t....h..p....l.ls..........h.s.t.p....h.h....t..t....s.t.p...l...h.tpht...............................hshhDshlh.AhA.........ht...tshs...........ll.T.tD.p.c....htt....h...........................................................................................................................	0	858	1797	2312
+720	PF04696	Pinin_SDK_memA	pinin_SDK_memA; 	pinin/SDK/memA/ protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4141 (release 7.5)	Family	Members of this family have very varied localisations within the eukaryotic cell. pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque [1].  SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing [2].  memA is a tumour marker preferentially expressed in human melanoma cell lines.  A common feature of the members of this family is that they may all participate in regulating protein-protein interactions [3].	25.00	25.00	25.70	25.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.86	0.71	-4.55	11	266	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	204	0	185	268	0	123.00	32	28.27	CHANGED	pDpcp+.tRNRRhFGsLLGTLQKFpQEpshh..spppc+Rs-IEpKl......EcQtctERcplccc+cpLap-R+ccQhElRtLEpKhtchc..cpWppp.thltpa.I+T.KTcP+laahPtphsspppKhLcEs.pc-sp	...........spct+.pRN+R.....hFG.t.L.h.G.TLp+Fpp..E..p..p.h.............op....ppc..RR....pEIEp+h......-t...ptcp.E....c.cp.l...c....p....c++....p..ht....-.+R....t.c....ph.plR..th.-p..ch...t.....t..p....h.h...c....php.pp.tthtpa.l........+.....T..+scP.l.........aYhPhchs.tspphlppp..pp..................................	0	68	102	150
+721	PF01504	PIP5K		Phosphatidylinositol-4-phosphate 5-Kinase	Bashton M, Bateman A	anon	Pfam-B_571 (release 4.0)	Family	This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in [1]. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the  phosphorylation of phosphatidylinositol-4-phosphate a precursor in the  phosphinositide signaling pathway.	20.20	20.20	20.40	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.86	0.70	-5.27	117	1752	2009-01-15 18:05:59	2003-04-07 12:59:11	13	60	323	8	1132	1665	41	260.10	28	29.93	CHANGED	hSL......ssp.....h.phsosGK..........SGS.hFahopDp+FlIKTl.p+...pEhc......................hhhc..hLspYap.alppssp.........................TLLs+h....aGlapl.........................p.....ss...pcht...........................hlVMpNlF....st..hplc.......cpaD........LKG.Sphs...........................Rpsp.............................t....p........tt.............sLK......Dhshhp.......phlhlstpp+phlhcplppDspFLpphplMDYSLLlGl....................+........................................................................................................................................thh...t..........................ptlhalGIIDhLppYs..hpK+lEphhKsh.hhs.t.....pslSslsPppYucRFh.cFlpphh	.......................................................................................................................h...sssG+SGu.hFaho.t....Dc+alIKol....p+.....pEhp..............................hhhc..hLs.tYap...a....l.pp.s..p.......................................TLLs+hhGlapl.............................t.h..su...pphp..................................................................h...l.VMpNlF............s........hph.p............................ppaD........L..K.G.Sphs...................................................Rpsp..............p.....pt.ptpt................................................tsshK..D.shhp...................phlhls.t.p.tp.phlh.cplpp.Dsp.....aLp........ph.plMDYSLLlGl...........c..................................................................................................................................................................................................................................................................................................................................................................................s......................pc.hha.hG.II..D..hLpp.Ys............h.pK+lEphh.K...sh.hhs..s........pphS.s.lsPp.YtcRFh.c.hhpph.......................................................................................................................................	2	374	629	900
+722	PF02171	Piwi		Piwi domain	Bateman A, Hammonds G	anon	Bateman A	Family	This domain is found in the protein Piwi and its relatives.  The function of this domain is the dsRNA guided hydrolysis of ssRNA. Determination of the crystal structure of Argonaute reveals that PIWI is an RNase H domain, and identifies Argonaute as Slicer, the enzyme that cleaves mRNA in the RNAi RISC complex [2].  In addition, Mg+2 dependence and production of 3'-OH and 5' phosphate products are shared characteristics of RNaseH and RISC. The PIWI domain core has a tertiary structure belonging to the RNase H family of enzymes.  RNase H fold proteins all have a five-stranded mixed beta-sheet surrounded by helices. By analogy to RNase H enzymes which cleave single-stranded RNA guided by the DNA strand in an RNA/DNA hybrid, the PIWI domain can be inferred to cleave single-stranded RNA, for example mRNA, guided by double stranded siRNA. 	19.90	19.90	19.90	20.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.82	0.70	-5.45	18	2067	2012-10-03 01:22:09	2003-04-07 12:59:11	12	30	421	62	1282	2033	12	263.30	32	35.31	CHANGED	hllsllsc.pspsh.YtslKKhhps-hsl.oQslphcshhph..........tphhsNlhlchNsKlGGhN..hhlsshsh.......pshh.........llGhDlsHsssup..........tssoluuhluohs.ppsspahussphpppsp-hlss.lpp............hltchLpsapcsspp.pPp+IllYRDGsuEGph.plhp.Elspl+cshc.......plspsap..PplshIllpKpppsRhFspstsp........................tt.Ns.PGTlV...DstlspPpth-FaLsupsshpGTs+Ps+YsVlhD-hthss-cl.QpL......oYpLsahahpsh....pslulPsPlaYAcplAttstpphc	......................................................................................................................................................h.hhhll..st...pt....h..Yst.lK+h..s.p...h....h..sh..........oQsl...p..p.h.p....................ph...hss.l.sh.......plNsK..........l..........GGh..........hhh..p.........................tssh..................................hl...GhDVsHssssp................................................ts..Slsu.......h...Vu.Shs.......p....s.....c....a......h.....u...p.sp...h.........Q...........p......t......p.....p.......E.........h.l......ps...ltt...................................................h.hpph.L.h...ta........h............p........t...........s....t........t..................h........Pp...+I...lhY....R...............DG.Vo-GQh.t.pl.h..p..El....t.lc...pu.ht........................p.h...t...........s..hp............Ptlohl.lVp.K..R..H..poR.......h.......F....s...t..stpp.........................................t.t.Nh..s......GT.l..V.......................Dp.t..l..s......p..P..p.......t......a....D..F.a.L.s......S..+..t..........u..h................p......G..T...u.+.Ps+Y..pV..l...h...D....-..........s.............p..........h..s...........s...D.....pl....Qp....L..................Tap.L.Caha.h.pss.................p.slsls..sPshYAchhuhhst......................................................................................................	0	440	645	1059
+723	PF00801	PKD		PKD domain	Bateman A	anon	[1]	Domain	This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold [1].	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.26	0.72	-4.23	93	5437	2012-10-03 16:25:20	2003-04-07 12:59:11	15	708	991	15	2785	5152	1955	70.40	22	13.50	CHANGED	hsss.........shhstslpFssps....s................Gssssap....WsFGD.......................stsssptsssHsYsp......................sGsYsVsLssssssussss	.........................................................s...........h..s.slpFssps.......s..........................us.s..s.s....ap.............WsFGD........................sssu.s.t..t...s...s...s..H.s...Y.sp.....................................................................sG...s.Ys.VsLol.ssshut...t.........................	0	1060	1676	2066
+724	PF01477	PLAT		PLAT/LH2 domain	Bateman A	anon	Bateman A	Domain	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain.  The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners.\	The structure of this domain is known for many members of the family and is composed of a beta sandwich.	20.80	20.80	20.80	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.52	0.71	-3.70	84	3359	2012-10-02 11:40:54	2003-04-07 12:59:11	18	189	280	91	1790	3171	14	109.70	19	17.37	CHANGED	hplplh....utphtussst...h.h.lhs.spGcssphthhps.h............ssshphphch..t....slG.lttltlppt......................hps.paalppl.hltt.....hsst.sph.pFss......pp.Wltss.........phhhh	.........................................Yplhlh.T...ut...t.u.u.Tssp.......lhltlhG...pp..G...c...o..t...p.h.....l.h.psttt...................................tsstppF.p...l..ps...t........slG..p.l.t.plp.lt+c.......................st.shps..sW........alc..pl..hlps...................s.t....p.p..h...hFss.......pp.Wlstpp............................................................................	0	578	838	1202
+725	PF00614	PLDc		Phospholipase D Active site motif	Ponting C, Schultz J, Bork P	anon	Alignment kindly provided by SMART	Family	Phosphatidylcholine-hydrolysing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of certain types of transport vesicles or may be constitutive vesicular transport to signal transduction pathways.  PC-hydrolysing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins. Each of these appears to possess a domain duplication which is apparent by the presence of two motifs containing well-conserved histidine, lysine, and/or asparagine residues which may contribute to the active site. aspartic acid.  An E. coli endonuclease (nuc) and similar proteins appear to be PLD homologues but possess only one of these motifs. The profile contained here represents only the putative active site regions, since an accurate multiple alignment of the repeat units has not been achieved.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.70	0.72	-6.96	0.72	-4.02	48	1567	2012-10-02 13:01:53	2003-04-07 12:59:11	17	33	652	3	833	6708	176	29.50	40	4.30	CHANGED	hshhhHpKhlllDcc............hsalGuushsssp	........hhsHHpKhlllDsp.................luFlGGlDLs.tp......	0	219	475	677
+726	PF01690	PLRV_ORF5		Potato leaf roll virus readthrough protein	Bashton M, Bateman A	anon	Pfam-B_1335 (release 4.1)	Family	This family consists mainly of the potato leaf roll virus  readthrough protein. This is generated via a readthrough  of open reading frame 3 a coat protein allowing transcription of open reading frame 5 to give an extended coat protein  with a large c-terminal addition or read through domain [1]. The readthrough protein is thought to play a role in the  circulative aphid transmission of potato leaf roll virus [1]. Also in the family is open reading frame 6 from beet western yellows virus and potato leaf roll virus both luteovirus and an unknown protein from cucurbit aphid-borne yellows virus a closterovirus.	27.40	27.40	27.70	27.70	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.73	0.70	-5.34	14	317	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	35	0	0	332	1	377.50	41	71.26	CHANGED	VDup.PsPsPuPsPtP...PsPoPEPsPs.p+cRFhs.YsGsPpshIpsRpsoDuIsltslssQphpYIEDEshshpslsutWhosNslpA.PhFlaPVPcGpaSVpISCEGaQussshusspcGphpGhIAYsssss.csWNVGshssssITNh+usNoa+.GHPDLclNuC+FspsQlVE+DuhlSFHlpsssp-usFaLsAPslpKouKYNYsVSYGsaT-+cMEFGhISVslDEp..-utpsupcs+pshRsGHh.hhspshc...sh.P.ssp............tpps.pTPssshspst..........................p....s.pcslspsp..ss.s.............pp.shth.thph.sstlsssspphh.sptt..................................ssc.lcs.sss.hs.shspssphhtsh.t...h..s.s.h.......ts.sPs.................slhsspp.pu............ShtuppLpGssh+tpst..pspshp.phosppptpYpRl+pohGhTsAcpahppht	.......................st.s.sPpPsPsPp....PtPsPpPsP....pRFht.Y.GsPpshIpsRpNo-tIsltplts.sMhhhEDEshshpplsutahsNNphpA.shhlaPVscGpa.SV.IpCEGaQuspphusspcGph.GhIAYsssp..csWslGsYsGssIoNhhsssoa+.GH.D...hclNuspFsptQlVERDhshSFHlcss.ppupFhLhAPslpKos+YNasVSYGsaT-+hMEaG.ISVslDEp..tu.p.....sphscps.h+ss+h..hsps.p.......s...p...............................................t.ts.ppP.t.........................................................................ph..............................p.s.h............tst.....l......ts....h.tt........................................ssp.hc....t.hs...s.p...hss.............s...h..........s.ssp...........................ph..ttt....t.........................................................s..st.lpusp..tt....p.phh..phoppphtpYpplpps.s.ssAptah.t..t.......................................	0	0	0	0
+727	PF03126	Plus-3		Plus-3 domain	Bateman A	anon	Bateman A	Domain	This domain is about 90 residues in length and is often found associated with the Pfam:PF02213 domain.  The function of this domain is uncertain. It is possible that this domain is involved in DNA binding as it has three conserved positively charged residues, hence this domain has been named the plus-3 domain. It is found in yeast Rtf1 which may be a transcription elongation factor [1].	21.20	21.20	21.20	21.60	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.23	0.72	-4.00	39	464	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	274	4	319	438	6	106.20	28	16.55	CHANGED	c-lpplplsRohltchhhpP.tF-pslhGCFlRlslGsscpptt.....YRlspIpulppst...sYph.......tphtTshhlplppup..pp+.aphshlSspshscpEapcah.pphtps	.....................plpclpLsRspltchhthP..hFc.csltGCFVR.lslGs..pppp............YRlspItslscss...sYpl...................sshpTsphLpl......ppGp......sp+.aphphlSs.ptFo-sEapcahpsh...h...................................	0	102	178	263
+728	PF04043	PMEI		Plant invertase/pectin methylesterase inhibitor	Yeats C	anon	Yeats C, McQueen A	Domain	This domain inhibits pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex [1]. It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension (see [2]). It may also be involved in inhibiting microbial pathogen PMEs. It has been observed that it is often expressed as a large inactive preprotein [1]. It is also found at the N-termini of PMEs predicted from DNA sequences (personal obs:C Yeats), suggesting that both PMEs and their inhibitor are expressed as a single polyprotein and subsequently processed. It has two disulphide bridges and is mainly alpha-helical [2].	26.70	26.70	26.70	26.70	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.24	0.71	-4.31	142	1441	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	79	25	905	1470	0	147.00	18	43.47	CHANGED	sss....tp.hlp...shCpp..Ts.......st.hChpsLss.......tttsss.p...s....lhphsl.phshspsppshshl.p....plhtp....................spstpt..ps......slp....sChchhssul.c.pLp.puhpsl.............................pt...sc..........spsh.lSuAh....sstpoCt..-uh.................pts..h.......p.h...pt......pslpcl.......sssuLul	..............................................................s....t.lpthCpt.....o...............st.hChpsLts............tstsss.p....p............lhphul..phshs..psppshshh.p......plhpt....................sts.pt....ps....ulp.......sC..h.c.h.hst...ul..s.pLp...puhp.sl.................................pt...ss..........spsh.lS.u..A.l....sstpTCh.....-ua...................tpsthp.....s.lt.....tt......pphtphsssuLuh....................................................................	0	137	531	706
+729	PF04721	DUF750	PNGase; 	Domain of unknown function (DUF750) 	Waterfield DI, Finn RD, Pollington J	anon	Pfam-B_4045 (release 7.5)	Family	This family of proteins with unknown function shows similarity to PNG-1, a enzyme responsible for de-N-glycosylation of misfolded glycoproteins in the cytosol [1]. However, unlike PNG-1, this protein does not contain a catalytic triad in its transglutaminase domain [1].	21.30	21.30	21.30	22.10	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.14	0.72	-3.98	23	98	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	42	4	71	108	0	62.70	37	13.79	CHANGED	pNYlKFTYDllssoYS+sscDGSslp.PahlpNlcRl.-........pp.stsYlcp.pstc.u.........................ItWpFs	......h.......YsllcDpY.....s+sss.....s.....spslp.....sac.....hcsIhRKVE........pDWphVYLsR.cEuss.uh........................ISWKF-......................	0	42	46	55
+730	PF03726	PNPase		Polyribonucleotide nucleotidyltransferase, RNA binding domain	Griffiths-Jones SR	anon	Bateman A	Domain	This family contains the RNA binding domain of Polyribonucleotide nucleotidyltransferase (PNPase) PNPase is involved in mRNA degradation in a 3'-5' direction.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.72	0.72	-3.71	21	4259	2009-01-15 18:05:59	2003-04-07 12:59:11	9	35	4196	34	982	3077	2312	81.70	30	11.36	CHANGED	sLhpcltslApsclupAapI..ssKp-RhsplDpIKspVhtthh...tppt......phsppclpslapsLcpclVRppIlsspsRIDGRc	............................................L.splpshs.p.s.c.l..pc.Ah..pl.......p-KppRpstlc.tlK....pclhs....phh.............t...p..p..p..................................................ph..s..t..p.-...ls...p...h.hc...plc+clVRptIlssch......RlDGRc.....	0	334	637	830
+731	PF01357	Pollen_allerg_1	Pollen_allergen; 	Pollen allergen	Bateman A	anon	SCOP	Domain	This family contains allergens lol PI, PII and PIII from Lolium perenne.	20.70	20.70	20.90	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.82	0.72	-4.18	136	1558	2009-01-15 18:05:59	2003-04-07 12:59:11	16	11	171	13	632	1490	0	77.50	40	32.72	CHANGED	lpFplsut...saa.hVLlpsluGsG-lssVplK.......................G............o....s....WhsMs+sWGssWp..hss...th.hst.sLSFRl..Tot-..Gpslsu.psVlP	..................l+FslsGt....s.aa.hVLlpNVuG.sGDltuVslKt..............................................st............o......s.Wh.s.Ms.R..N...........W...G.....t..s..........Wpssu...hh...st.....sLSF+l..Ts.s-...G..+..slsu...sVhP..............................	0	78	341	494
+732	PF01522	Polysacc_deac_1	Polysac_deacet;Polysacc_deacet; 	Polysaccharide deacetylase	Bashton M, Bateman A	anon	Pfam-B_502 (release 4.0)	Family	This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB (nodulation protein B from  Rhizobium) which is a chitooligosaccharide deacetylase [1]. It also includes chitin deacetylase from yeast [2], and endoxylanases which hydrolyses glucosidic bonds in xylan [3].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.34	0.71	-4.49	104	13288	2012-10-03 16:37:10	2003-04-07 12:59:11	16	176	4258	46	3692	10795	3031	133.50	20	38.42	CHANGED	ttsssp+slhLTFDDGs................................sshssplLslLpchplpATa.FllGp.h...sppt...............................................................................sphl+chhppG.aplusHo...................hsHs.......ph..........sshssp.phpp-lppspphlpph..sGp.psph..hRsPaGt......hssss....hphspphGhphs	..........................................................................................................t....tp.lhlT..F.D.D.G.................................ts.h.s..s...p.l.l.s.....l.......L.......c.......c.......h.........s........h......p.......A..T..a..Fl..hup..h..........hppt.............................................................................................................s.p...h.l...+..c.h.h..p......p..G...ac......l..u.s...Ho.........................................................................a..s..H.................ph............................................................sp.h.stp..ph....p.p....-.l...t....c...s....p......p....h...lp...ph................h...G...p....p.....s.ph................hp.......h...P..h..Gt..........hs.p..p..s.......h.p.hh.tt.th...h..........................................................................................................................	0	1356	2490	3163
+733	PF04831	Popeye		Popeye protein conserved region	Mifsud W	anon	Pfam-B_3905 (release 7.6)	Family	The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains [1].	28.10	28.10	28.10	28.70	26.40	27.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.83	0.71	-4.47	10	249	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	76	0	142	229	2	145.50	45	44.99	CHANGED	EhcuLYpslapPLpVPlclF+cIstshtscVpoLpp-psYAlEGKTPI.DRLSlLLSGRl+VSh-GpFLHYIaPaQFLDSPEW-SLRPSEEGtFQVTLTA-s-C+YloWpR+RLYLLLsp-RYIuRLFSlLLGpDIu-KLYuLND..KlauKpGhRh	..............................Ehp.lYpslFpPLpVshphF+clstsh.pplhoLcptpsYAhEscTsl.D.+LSlLLSG..........+.........l+VS.c.GpFLHhI.aPhQFlDSPEWcShp......o..c-.shFQVTlsA-ssC+alsWpRc+LphhLtp-taltclFshLlGpDIscKLYuLN-..phhsphth..h...................	0	36	47	88
+734	PF01558	POR		Pyruvate ferredoxin/flavodoxin oxidoreductase	Bashton M, Bateman A	anon	Pfam-B_350 (release 4.0)	Family	This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein.  It is not known whether the  gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms [1]. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA [1]. The family also includes  pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited [2]. 	20.70	20.70	20.90	21.30	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.99	0.71	-4.36	119	5899	2009-01-15 18:05:59	2003-04-07 12:59:11	13	69	3035	27	1854	4841	1225	177.10	23	24.80	CHANGED	G..GpGlhosuplLupus.hppG...ht.lhshppausphR......GGss.hsplR.lus.c..h......sth..t.psDhlluh................ct.psh..t..phhst..lpss......Ghllh..ssshhsst.ht.th.........................................slsh...pclAt.........chhs.......shhhNhlhlGsh.....sthhs..lsh..-s.....lppslcpphs.tt......................thlctNhcAhctGhp	..............................GGpGslsuuchhsphh..tp.ps...................hh...spsh.sas..ucp+......G.G.so.huclR..huc..p.hh...................sshhh.s..psDhllsh..................s..thl.p.......phhpt...l+pG........Ghhll....No....hh...ss...p..th.tpth..................................................................phhhlsu.splAp.............................-h.sh...............stthNhlhhuuh........h..plss...lsh..........-s...........hhctlcpp.....hs.pp.......................pll-hNhp.AlctGh............................................................	0	715	1316	1619
+735	PF01855	POR_N		Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	Bateman A, Griffiths-Jones SR	anon	Pfam-B_323 (release 4.2)	Family	This family includes the N terminal structural domain of the pyruvate ferredoxin oxidoreductase. This domain binds thiamine diphosphate, and along with domains II and IV, is involved in inter subunit contacts [3]. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited [2].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.34	0.70	-4.85	32	5386	2012-10-02 16:07:47	2003-04-07 12:59:11	14	71	2734	21	1633	4863	884	224.70	28	29.55	CHANGED	puuhtss.cshuuYPITPuos..hsEthsphhspuph..........phlphEuEhuAhuslhGAuhuGu+shTuTSu.GlhLMhEslhhhuupchPhVlhlssRuhsusulslhs-psDhhtsR......-sshhhLsssslQEuaDhslhAatlA.c..splPshhhhDGahsoHphpplpl.s.-.....hhcp.h.shcchp.........hhsP.cpPlstsstts.sshhptcctst.shptstthhpphhc	...........................................h.suhtss.c.h.h.uhYPITPSSp............hsEhhs..p.h....t.spstt.......................phlp..h.p.s..E.h.uAhuss..h.G.As..h...u.G.uh..s..h.T.s.Tu.u.GL...L.Mh-..s.l.h.h..h...u...s.p..tl..P..h.Vlhs..ssRus.....supuL.sh.hs-...p.uDl.h.ts.p.......ps.s.h.s.hLss..uos.QEsh.Dhsh.hAaphu.c.......hpsPhlhhhD.......G.....h..h..s.......H...t....h....p....p.....l...p..h.......c..c..........h...........t.....h....h.....t.p.........h....h.t.t....p...p.......................thss...pt...s.........h..h.s.s...............s.h.h.h.p..tptth......p..........................................................................................................	0	680	1192	1447
+736	PF04151	PPC		Bacterial pre-peptidase C-terminal domain	Yeats C	anon	Yeats C	Domain	This domain is normally found at the C-terminus of secreted bacterial peptidases. They are  not present in the active peptidase. It is  possible that they fulfill a similar role to the PKD (Pfam:PF00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C).	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.72	0.72	-3.01	151	2040	2012-10-03 16:25:20	2003-04-07 12:59:11	10	196	870	21	476	1650	202	70.40	24	12.12	CHANGED	spchaphsls..suss.ls..ls...l.......suss............................ss-..Lh..lhtss......s.....shss......hssts..............tss.....................ssppss..hss.....spsGs.Y.altltu	.......................................t..phashpls....sups..ls...ls.....l............ssts............................ssD.........la...lhtss.........s....................shss.......hssps.........hpsu.................................ssppss...hss.....stsG.p..Y.altV..h..........................................	0	158	302	417
+737	PF01577	Peptidase_S30	Poty_P1; 	Potyvirus P1 protease	Bashton M, Bateman A	anon	Pfam-B_364 (release 4.1)	Family	The potyviridae family positive stand RNA viruses with genome  encoding a polyprotein. members include zucchini yellow mosaic virus, and turnip mosaic viruses which cause considerable losses of crops  worldwide. This family consists of a C terminus region from various plant potyvirus P1 proteins (found at the N terminus of the polyprotein). The C terminus of P1 is a serine-type protease responsible for  autocatalytic cleavage between P1 and the helper component protease  Pfam:PF00851 [1,2]. The entire P1 protein may be involved in virus-host interactions [1].	19.70	19.70	20.00	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.39	0.70	-4.98	26	1446	2012-10-02 13:45:52	2003-04-07 12:59:11	11	18	127	0	1	1522	0	212.30	29	12.60	CHANGED	tpppsphttchhppp.....huphchpcpuphhh+thstptltcpppptpppccpppp.....hphthsshssshshttttthscstssphppt.hhppospch+pptspcphttssp.lstlhcplhpIspccshsVElIuK++..tspspa++hpushhhplpltHhpGphp+hDlshsphtpplhthhutpttppppspshph..GsSGllhpspphhs.hthsptshFlVRG+psGp....Ll-ARs+lspt.hpplcH	..............................................................................t...t.p.pthhhc.c...........uhhh.tpp.p.tslhhp...h.tspp...l.+.ppcthcp+ctcEtp.......h.h.thp.s..h.stho.h.s.ss..sss.t..hp....s.ph.ppt.......hppo....ph.......+c.p...h.s.h..p.p.s.+.....h.spt..hp....hlh+plhpIhp..tp.s.ts.lEh.Iu++p....hclpahc.h.t..t.s.phstlpssHh...G.h.....+.....tp.....h...D..h.....hs......p.t...hhlphhuth..st.p....p..hpshslp.G.SGlllpst.l...ht...hs..+s........p.p.........hFllRGc..c.c.G+....LhDARt+lop...pcl.p......................	0	0	0	1
+738	PF03291	Pox_MCEL		mRNA capping enzyme	Mifsud W	anon	Pfam-B_4078 (release 6.5) & Pfam-B_3482 (Release 7.5)	Family	This family of enzymes are related to Pfam:PF03919.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.17	0.70	-5.57	11	647	2012-10-10 17:06:42	2003-04-07 12:59:11	11	21	389	17	358	751	441	284.20	25	61.34	CHANGED	ch..ppspshsshVssH...........Ysch............pcss..hchRppSsIhp.............................................................................................................................................................................L+pFNNaIKolLIuhasp+s..c....sshpVL-lsCGKGGDL.KathutIuthlusDIucsSlppspcRY...pphppt.cpchh+hsa.schlsuDsahsplpEhahss......hpF..DllShQFAhHYSFcoccpAchhLpNlschLssGGhhIuThPDushl......++Lpt..t.stpcphGNslYploF-cp..........s.aGphYsapLcsslpssPEYlV.FssLhclsccYshpLl.phsFp-hhcp.h.p.cp+hhlpphsul-spsupp........................p...tshpusEhEAsh.hYllasFcKp	.................................................................................................................................................................................................................................................................................................................................................................................................................................................t............l.ta...........Ysth....................t...........+.tts.l............................................................................................................................................................................ht.hsN.a...l.KohLIp....a..................h..........p.............................................................................tt..............tV.LDlsCG..+G...u...DL.K.a.....h.....u..t...............l..th...............hl.shD...........ut.ul....p.p....spp....RY.................................t............................p.........p.............................a.......t....p...h.h.ht..D..............sh............p.....ltph..h..............................F.....cllsh.............F.shHYuFcspppu..........p.hhpNhs.thLp.GGhhluo..hssu.p.l...................................tpl....pt....................................t.........t.......ph...s......s....ph....h.tl..p..att..................................................hG.h.....ha...a....h........p.p...h.s......................t...........hsEalV.h..h..h.t.lhpcashp..Lh.....p.......sF.p.hhp.............................ht......................................................................................................................................................................................	1	117	205	299
+739	PF00481	PP2C		Protein phosphatase 2C	Bateman A, Finn RD	anon	Prosite	Family	Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.72	0.70	-4.99	31	7190	2012-10-03 01:39:20	2003-04-07 12:59:11	16	293	1352	43	4244	8910	707	218.80	20	49.91	CHANGED	hshshsphpuh+pphpDsphthtsh.t.......ssp.shshhslaDGpuGppsuchsspplt.....phlppppsh.ps.................thppsltpuahp..tc.thtp.....t..........s.puGsoAssshlpspc........LalANlGDS+slLspssssh...........tLopcHcPssts.EppRIppsGGhlp......sRlsGs.....................LulSRAlGDhphKs..............................hVsupP-ls..ptplsts.D-FllLAsDGlWDhlsspcsl-ll+pphst............spcsupcLhchuhshuop-sh	..................................................................................................................................................................................h.........................................................................h....hs.l.h.DG.....h.....s......G...........t.......s.....up.....h.ht....p...h..................t..h....t............t...........tt.................................................htp.h..l...t...p..s...hht........h.s.tthhp.........................................................t..tt.s.G..o..T..s.......s...s...s..l..l.....s.pp...................................lhl...AN..s.GD.........S...R..s......l........L...s.....p....p..st.h..............................................L.o..t.DH.p................s.....t.........p......................t......E.t....t....R...l..p..t.....t..t...u......h.....................+..lt....u..................................................................................................l.sh....o...R......u......h.........G...D.h.....hc.................................................................................................hl.st.P-.lt...............hp.l..........p...........p.....c..............p........a.......lll......us...............DG..l......a.....c..............h........h.......s.s....p......p........h.s..p.h.l..t..p......t...............................................hs.p.lht.s............................................................................................................	0	1476	2539	3487
+740	PF00823	PPE		PPE family	Bateman A	anon	Pfam-B_297 (release 3.0)	Family	This family named after a PPE motif near to the amino terminus of the domain.  The PPE family of proteins all contain an amino-terminal region of about 180 amino acids.  The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups.  The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.65	0.71	-4.40	146	3533	2012-10-01 21:44:22	2003-04-07 12:59:11	14	54	122	2	395	2191	1	151.60	45	28.01	CHANGED	slP..PElNSuhhauGPGuushlAAAuAWsuLAuELssuAsshsullusLs...sss.WpGPuusuMsAA.ssPYluWLsssAupAppsAuQAcuAAuAYEsAhAuhVsPshlAANRsthss..LlATNhFGtNosu.......IAssEA.pY.scMWuQDAsAMhuYtusuuuAss	...................................hlPPElNSuhha.uGsGsuPhlAA..AuAWcuLAsELssu.Asuas.u.llusLs..........sts.W.pG.PuusuMsAA.ssP........Ylu.WLsssAupAp.tuAsQAcAuAu..AaEsAhAusVs.P.s....h.lA.AN...R.sthhs...L..lu..o.N....h....h..GQNosA.........IAs.sEA...pY...tcMWAQ....DssAMhuYtuuuuuAs.t..................................................	0	97	190	347
+741	PF01535	PPR	DUF17; 	PPR repeat	Bateman A, Birney E	anon	Pfam-B_874 (release 4.0)	Family	This repeat has no known function. It is about 35 amino acids long and found in up to 18 copies in some proteins.  This family appears to be greatly expanded in plants. This repeat occurs in PET309 Swiss:P32522 that may be involved in RNA stabilisation [1]. This domain occurs in crp1 that is involved in RNA processing [2].  This repeat is associated with a predicted plant protein Swiss:O49549 that has a domain organisation similar to the human BRCA1 protein. The repeat has been called PPR [3].	25.00	9.30	25.00	9.30	24.90	9.20	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.38	0.73	-7.57	0.73	-3.61	518	31410	2012-10-11 20:00:58	2003-04-07 12:59:11	15	3797	468	0	23088	82367	965	29.30	21	15.97	CHANGED	hoassllsuascpGphccAhplhpcMpppGh	....................asslls.s..a..u......+......s....G....p.....h.......c.....c.....A..h...p..lacpM.t.......................	0	2628	15898	19987
+742	PF04193	PQ-loop		PQ loop repeat 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Repeat	Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop [1]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [2]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.69	0.72	-4.42	255	3702	2012-10-03 12:15:12	2003-04-07 12:59:11	9	33	711	0	2429	3643	533	59.40	21	35.09	CHANGED	huphlGhlshshhhlshlPQlhpNa+p+Ss.pGlShhhhhhhhhGshhthhhhlhpthsh.h	.........................h...hhGhhshhhh.h..h...s.hlP.Q...lhpsa..+.......p..+Ss.pGlShhhhhh..hhGsh..hhhhhhhhtt.....h..................	1	810	1368	2026
+743	PF05033	Pre-SET		Pre-SET motif	Bateman A	anon	Bateman A	Motif	This protein motif is a zinc binding motif [1].  It  contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.	21.80	21.80	21.80	21.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.44	0.72	-11.70	0.72	-3.75	86	1039	2009-01-15 18:05:59	2003-04-07 12:59:11	11	69	226	37	626	1020	2	109.60	28	14.91	CHANGED	chsput-s....hslslh........NplD............t-ts..P..tsFpYlsphhhsp...............................h....hstphhh.............GC.sC..p.......................ss....C...sspsC.Chpts.....st...h.................s.Y...sp.ptpLt................p...........................................sssIYECsspCpCs..t.sCtNR	.........................................................hs.uhEphslshh.........Np....lD......................sp.s........ssFp..Ylsp..hhsp................................sh.....hs.phh.........................uC..sC....p........................ss......C.......ssspC.Csphs..........tt...th.........................................s.Y..sp...pspLh.........................hpt...................................................sshIaECsptCpCs.......sCtNR.............................................	0	144	274	462
+744	PF00156	Pribosyltran		Phosphoribosyl transferase domain	Bateman A, Sonnhammer ELL, Finn RD	anon	Bateman A	Domain	This family includes a range of diverse phosphoribosyl transferase enzymes.  This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8 Swiss:P36766. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1 Swiss:P09329. Amidophosphoribosyltransferase EC:2.4.2.14 Swiss:P00496. Orotate phosphoribosyl-transferase EC:2.4.2.10 Swiss:P11172. Uracil phosphoribosyl-transferase EC:2.4.2.9 Swiss:P25532. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22 Swiss:P00501.  In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain [1].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.41	0.71	-4.40	71	30853	2012-10-10 14:25:38	2003-04-07 12:59:11	22	68	5141	299	7483	25977	11727	121.40	18	48.82	CHANGED	pslh...hs.ctlpphsct......lupp....lpppths.........llultpuGlshustluptLsh...shhhhhh.h...........................................tthtppsspththhhthst.hcucclllV.DDllsoGtTlptshc.hLc.pts.sp........lthsslh	..............................................................................................................................................................t........t..htthhpt......lupt..............h..h..p..p........h....p....h...............llu.......l...............p.......t.......G.....h.............hu..t.......t...l...u...pt.l.sh...........s.h..h...h..s..h.h.ttp............................................................................................................................ttt..t.ppp.s.....s..t....t..h...h...h...t...h.......p....s.........h....p...G.......c.....c.....V.ll.V..DDl.lsoG.sT.hp.t.h.hc...hlc...ptG...up......hl.tlssh.h........................................	0	2412	4803	6327
+745	PF00377	Prion	prion; 	Prion/Doppel alpha-helical domain	Bateman A, Finn RD	anon	Prosite	Domain	The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.	25.00	25.00	36.90	36.70	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.62	0.71	-4.38	7	730	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	240	88	41	750	0	107.50	71	50.15	CHANGED	hp+hshcFGs-.tsRYYptN.hpaPstlaYcshsphsVspptFVpsClNhT.stpphp............u..cs.schc.+Vhh+llcEhCstpapcahLt....Ruuulplhss.PhhLhlLshlhFlht	.......MSRPLIHFGNDYEDRYYRENMYRYPNQ.VY...YRPV.D.QYS.NQNNFVHDCVNITVKQHTVTT..........TTKGEN...FTETDlKhMERVVEQMCITQYp+EupAa...pRGu.ShlL.FSuPPVlLL.lshlhhll.s.....	0	2	2	9
+746	PF00227	Proteasome	proteasome; 	Proteasome subunit	Finn RD, Bateman A, Valas RE	anon	Prosite	Domain	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.99	0.71	-5.02	174	10806	2012-10-03 21:14:07	2003-04-07 12:59:11	21	55	3712	1970	5186	9052	2184	173.50	21	77.89	CHANGED	hppGs.TslGlc.sccuVllu...u.-p.+so..ts.hlhsppp..h..cKlhpl..scclhhshuGhsuDsphlhchhct.psp.hac.hp.hs.c.hslp........hushhpthh.t..pt...th.psh...s.s.shlluGhD.p.p.s...t.spLaph..-ssGshhph....hsuhG.suuphuhs.hl-ppa....pts..hoh--u...hclshcult.t..uh..c..pst...hss..ssl..plshl	........................................................................................................pus.Thlu......lp.....t.......p.......s.......t.....lllu.............u..Dp.p.....s.......o.......t..s...hl..........t........p.s..p....h..........cK..l..h..pl....s..............s........p........l....h..........h.u....h..............u............G...........hs.A...D..s...t..sl...............h....c.hh........c..........t........p.......h........p.............a........p........h...........................t......t.....h...s..lp.....................................h.........s.........t...h...h....t.....s.........h.....t..........pp...............ht.....p......s.h..................h.l....phlh...u...Gh....s...........t....s..........................t...s...p.la.h..l.sss..Gshh......p............p............h.......h......A........hG..uGu...phAhu.hh.......c......phh...................t...s........h.........s.......p..c..A..........hc..ls.h.culp.....uh....c....hs.h......hos..p.phpl........................................................................	0	1761	2940	4236
+747	PF03371	PRP38		PRP38 family	Bateman A, Winge P	anon	Winge P	Family	Members of this family are related to the pre mRNA splicing  factor PRP38 from yeast [1].  Therefore all the members of this family could be involved in splicing.  This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation [2]. 	22.40	22.40	22.80	23.00	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.81	0.71	-4.65	41	560	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	309	0	382	526	4	168.00	32	51.79	CHANGED	tsts..tlpspssshllppllRp+IhsShYaKpphaslss..........pollDchhp.lcalGuhhsust+...................PosFlCLLhKLLplpPsc-Ilhphlppp..................................-aKYlRALuhhYlRLshss...................t-laphhE....PhhpDaRKl+hpstsu...........plhahD-alDpLLsc-chhslhLPRl.tR..hhL-ppstL	..........................................tt......lhGsssphllppll+spIhsS.YaK.phatLss.........cpllDchhp...lcalushh.s.G.sp+...................................PoshhCLlhKhh.plp.s+c.lht.hlppp...............................................-.p..YlRALGhh....Yl.....Rhstss........................h-lapahE....Phhp...D.cclchpstsG..............................plhphschlcpLL.......pcpchhs..hhLPRl.hp..h.hp..t..h................................................	0	142	214	311
+748	PF01789	PsbP		PsbP	Bashton M, Bateman A	anon	Pfam-B_1303 (release 4.2)	Family	This family consists of the 23 kDa subunit of oxygen evolving system of  photosystem II or PsbP from various plants (where it is encoded by the  nuclear genome) and Cyanobacteria. The 23 KDa PsbP protein is required for PSII to be fully operational in  vivo, it increases the affinity of the water oxidation site for Cl- and  provides the conditions required for high affinity binding of Ca2+ [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.09	0.71	-4.82	30	539	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	153	5	301	551	149	160.70	22	65.89	CHANGED	hssshsshhshshsustutssuGhpsa.sssDGYpFLYPsGW...pcVpl....sGs-llF+Dll-ssEslSVslossscc...olc-LGoPpc........VGcpLhcphluspGus.....RpAcLlcAspRcss.G+sYYslEatl+hss.....t............sRHpLuolsVscG+LYTlssuosEcRW.K.scchhcpllsSFslh	..................................................................................................hs................................h...h....t....t.....aph..hPt.t.W.............................phth........G....................hh..acs..............t.....t.p.s......ls.V..hlss....s........spp...........sl.p..ch.Gs..scp...........lu...ppl...h..t..t.hhs.s.tt.....................tpupllps..pp......pp...h....s..G.....c.tY..Yp.hEhtsp.tss........t......................t+Htlssss..l....s..s.G.....+.......LYhhss...p...s...s.-...p...p...W...t....c...hcphlcpshsSFpl.........................................................	1	93	210	266
+749	PF01416	PseudoU_synth_1	PseudoU_synt;	tRNA pseudouridine synthase	Howe K, Griffiths-Jones SR	anon	swissprot	Domain	Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in  all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.52	0.72	-3.60	118	11373	2009-01-15 18:05:59	2003-04-07 12:59:11	15	22	4733	26	3331	8399	4001	104.70	20	69.27	CHANGED	hthtahGp.sFpuap.........pp....................pshp........pshh+sltphph................................t.t.........................thhht.h+hhh.......sshhcs.spGhpuhsplt....ph.............................................Lspph.s...........tssshs.hhhcspas	......................................................................................hta.Gp..cFpuap.....................................pp....................................................pohp.........psh...+slpch.ph................................................................................................................................................................h+.h..hl........................sshscs....st...Gs.c.uhsp.ls..ch............................................................................................................................Lssp...s...s..........ss..sss..hhcsca.................................................................................................................................	0	1157	2111	2810
+750	PF01437	PSI	Plexin_repeat;	Plexin repeat	Bateman A	anon	Bateman A	Family	A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin (Swiss:P70206) [1]. Two copies of the repeat are found in mahogany protein.  A related C. elegans protein (Swiss:Q19981) contains four copies of the repeat.  The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas [1] shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.03	0.72	-3.81	95	2947	2009-01-15 18:05:59	2003-04-07 12:59:11	20	228	154	27	1472	2447	7	54.60	25	6.46	CHANGED	sCsp......a..poC.s.sClsup.t..tCuWCst.....tppC....spts.........................pCtptp....................t.tpp..Cs	............pCst......a..poC.ssC.....l.....tup.....cs..hCuW...Cst........ttpC....spts..................................................pC.t.t..............................................................................................	0	251	365	805
+751	PF04046	PSP		PSP	Wood V, Finn RD	anon	Pfam-B_PSP (release 7.3);	Family	Proline rich domain found in numerous spliceosome associated proteins.	18.30	18.30	18.80	19.00	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.35	0.72	-4.57	40	488	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	300	0	335	464	3	49.30	49	8.24	CHANGED	+PGhlSpcLRcALGhssss.....PPPWLhpMpch....GhPPuY..PsL+IPGlshsl	.....+PGpLS..-EL+pALGhs.sss............PPPWLhpMQ+h...................G.PPSY..PsL+IPGLNss...........	5	114	181	270
+752	PF04468	PSP1		PSP1 C-terminal conserved region	Waterfield DI, Finn RD	anon	COG1774	Family	This region is present in both eukaryotes and eubacteria. The yeast PSP1 protein is involved in  suppressing mutations in the DNA polymerase alpha subunit in yeast [1].	21.10	21.10	22.60	21.90	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.78	0.72	-4.00	138	1828	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	1651	0	508	1317	149	88.50	40	24.33	CHANGED	slppllRhA...o..pcDhpphppscpcp.ccAhphCpp+lpccs.............................L..sMKllcsEa....pFDpsKlhFYao......A-sRVDFRcLVK-LAphF+sRIEhRQI	............................................................................lKpllRhA...sppDlpphp.cscpct.ccAhplCpcplpcps........................................................................................................................L.......cM+LlcsEY..................shD.....p......sKll.FYFT.............A.-.sR...lDFRcLVK-LAphF.+.T.RIELRQI.....................	0	218	376	469
+753	PF04024	PspC		PspC domain	Bateman A	anon	COG1983	Domain	This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	21.80	21.80	21.90	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-8.93	0.72	-4.50	182	3398	2009-01-15 18:05:59	2003-04-07 12:59:11	7	17	2305	0	732	2173	337	60.70	32	37.58	CHANGED	pp+LhRsp....ps+hluGVCuGlAcYhslD...ssllRllhll...h.hl...........................h..sss...sl..l.........hYllhh..lllP..ppss	.....................p+LhR.s..psphluGVCuGlAcaas.l.-...ss.lVRllhllhsh............................hsss.....ull.........hYl.llh..hllPtt..s..............................	0	264	511	639
+754	PF04886	PT		PT repeat	Bateman A	anon	Pfam-B_517 (release 7.6)	Repeat	This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.01	0.72	-4.63	15	489	2009-01-15 18:05:59	2003-04-07 12:59:11	7	108	180	0	258	482	734	37.20	41	7.69	CHANGED	pPTspPospPTspPTupPospPTspPTspPostPos	.............................PotpPTspPTsp.PT..spPTs.pPT.spPTspP.ottP.....................................	0	131	163	221
+755	PF01329	Pterin_4a		Pterin 4 alpha carbinolamine dehydratase	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerisation cofactor of hepatocyte nuclear factor 1-alpha).	20.80	20.80	21.20	21.00	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.29	0.72	-4.23	136	2229	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	1838	50	880	1778	2287	90.20	32	78.95	CHANGED	s.s..s.hLoppchpph..Lp.pl..s.....sW..plt...s...........tplp+p.apFcsFtpAh...uFhspVuhlAEptsHHP-lts.sascVplphhTHcl....s..G.LocpDhhhAs+h-plhp	....................................................ht....lsttphtth..Lt..tl.....s..........sW...p..h.......s..............stlp+.p.a..pFp.s.......Fp.pAh..................uFh.s.c.lAhh.AE.......ph.s.......HHP.-.hhs....s.........as..p.........V.plsl..h..TH..sh............s...G...locpDhthAtph-tlh.t...........................	0	282	549	745
+756	PF03095	PTPA		Phosphotyrosyl phosphate activator (PTPA) protein	Mifsud W	anon	Pfam-B_2456 (release 6.4)	Family	Phosphotyrosyl phosphatase activator (PTPA) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. The specific biological role of PTPA is unknown, Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [1].	20.10	20.10	21.30	20.50	20.00	19.70	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.06	0.70	-5.25	53	620	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	316	20	404	615	5	265.50	37	78.11	CHANGED	tPsKRIhss.pDlphFtpStsapclhsFlpslsculpGpphs..........pshthSs...........................................slppllp.lLcclppllccsPP....hct.s.sRF......G...NhuFRsaa-clp...........ppsssllpphlss.................ttpsslsELssYlhpS..FGsppRlDYGoGHELsF.lsaLhsLhclu................llp.pp.........D.............hssllLtlFscYlclhRcLphsYhLEPAGSHGVWGLDDapFLPFlaGuuQhhscsh.hp........................Ppulpsppll.........-.papcpahYhssIsFI.splKou........shp.HSPhL.DISust.sWsKlpp................GhlKMYpsEVLuKhPlhQHFhFGs.Lhshscshss	..................................................h.P.+cIhs..tDhthahpS.......satphhsFlhp.lscultspphs................t...st..................................................................................slpplht.lLsplpphl......cchPP.........pt..s.....pRF..................G...N.huaRpahpc.lp...........pps....plht..ph..l.st.........................................................................t.tts..h.ElssYhhpS..aGstpRlDYGoGHEhsF.hhaLhsLhpls............................hhp..tp-...........................................sllhtlF..pYlp..lhRpLphsY..hLEP.AGSH....GVWGLDDapFLPal.aG..uuQ..ht.p..h...hp...............................................Ppphhptphl..........p.p..t.pphha.hpslt..al......pp.hKpu............shttHSs.L.sISus...sWsKlpp................GhlKMYp.sE..VLtKhPlhQHFhFGs..Lhsh.....s........................................	0	157	237	341
+757	PF02302	PTS_IIB		PTS system, Lactose/Cellobiose specific IIB subunit	Mian N, Bateman A	anon	Pfam-B_9339 (release 5.2)	Domain	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases.  This family also contains the fructose specific IIB subunit.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-10.36	0.72	-3.50	245	18949	2009-01-15 18:05:59	2003-04-07 12:59:11	12	57	2638	16	1606	8004	181	89.10	20	29.08	CHANGED	pllssCssGhuoShhstpplcctscptG........l-s....pstsss...hptpphts.s.Dllllus...plp......phpphss............hhhlshps......hh..tsscpllpp	................llssCssGhuoShhstptlcctspchG................................l-s....psssss.......hp.tps.h..tp.s..Dll..l.hus.plp........phpphss........h.........h.hlshts....hh....phtthh....................................................	0	438	856	1245
+758	PF01472	PUA		PUA domain	Bateman A	anon	Medline:99193178	Family	The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes [1].  It is predicted that the PUA domain is an RNA binding domain.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.05	0.72	-4.25	108	4603	2012-10-02 17:37:24	2003-04-07 12:59:11	15	42	3369	67	1812	3731	1805	74.30	29	20.31	CHANGED	splhlDcuAscultp..Gu.sLhssGlhpscssh......ctG-hVhlhsp....p.G........chlAhGhuthsupEhtchp..tttusclcphl	....................GplhlDcGA.spAlhp.....Gs...SLLssGlh......p.....l......pGsF............................ptG-sVt..lh..st...................p.G..........................................ctlA.pG..lspasus.cl.p..p..ht...tth.utcltt.............................................................	0	564	1073	1503
+759	PF01480	PWI		PWI domain	Bateman A	anon	[1]	Family	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.59	0.72	-3.88	34	907	2009-01-15 18:05:59	2003-04-07 12:59:11	12	44	271	2	602	867	4	72.20	28	10.85	CHANGED	l-llKsWIsc+ls-lLGhEDDlVl-ashshLp......................tpc....DsKplplpLsGFLs.+suttFsp-LWcLLluApps..pG	........................-hlKsWls++lp-..l.lG.h.-...-......s..s.l...l-a.lhsh.lctt...............................s..c.p.h.h.p.pLss..F..Ls..ccs...pt..FlpcLWchll.tppt...t.............................	0	199	312	474
+760	PF00787	PX		PX domain	SMART	anon	Alignment kindly provided by SMART & iterated	Domain	PX domains bind to phosphoinositides.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.35	0.71	-4.28	71	7076	2009-01-15 18:05:59	2003-04-07 12:59:11	19	282	785	46	4186	6459	70	114.90	20	19.35	CHANGED	sthhp..hthss.t.......spttthhhhplphpss..............tphpltRRYp-FhpL+ppLpcphs.....................thhlP.hPsKthh......................................................hppphlccR+.ptLppaLpplhppPhhtp.....schltpFLpsp	........................................................................ht............................tththhh..h.h..plp.hpss..............................pht..V...hR.RY..p-..F..ttL....cp..p..Lp...cpas.........................................................th.h.lP......lP.t..Kp.h.h.st...........................................................................................................................................................hppp...h..l...c...c...R+...p.tL.p...paL....p..............p...l..h....p....p..s..h..ltp......sphht.pFLp..t....................................................................................................................................................................................................	1	1382	2076	3184
+761	PF02194	PXA		PXA domain	SMART	anon	Alignment kindly provided by SMART	Family	This domain is associated with PX domains Pfam:PF00787.	21.10	21.10	21.30	21.10	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.17	0.71	-4.72	69	830	2009-01-15 18:05:59	2003-04-07 12:59:11	10	30	257	0	547	794	2	167.90	23	19.45	CHANGED	sstlsptlppll..shll+-FVps.WY.ppIossp..pFss.plcpslppsltplppRlp...............phDhssllspclhsllspHlphappAppth.............................ht...spspthplhhshphpss.....csA.htsptpphp.........................................alRtlspslLshlLsppphpstslpsLl+ElLussVLhPllp.hlu-P-alN...phIlthhpss	............................................lsttlppllphllc-aV.s.WY....pp.........l.o.scp....pF.p.pl.cpslpthhtp.lpp.R....h.p...........................cl..D.h...sl..l.............sp.......cllshhspHlphhp.pAppth...........................................................................ttt...p...hp.h.ht.p.t.t............hc.u..h....psp....pppht....................................................................................................................aLRpl.sp.hll...hl.LP.......pt.............h..........p.......sp.......shphllpEllu....ssl.lhPh.ls.hlucP-hlN...phlhhhhp..s...............................................................................................................................................................................	0	173	277	432
+762	PF00070	Pyr_redox	pyr_redox; 	Pyridine nucleotide-disulphide oxidoreductase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.49	0.72	-3.57	130	40648	2012-10-10 17:06:42	2003-04-07 12:59:11	22	455	5442	395	10595	41559	13431	81.90	22	17.40	CHANGED	+llllGGGhIGlEhAshh....pp.hG...t..cV.ollcttsplh....hhstp.huphl..pcph.ccp....Glplhhssplpplp......tsss.t....lhhp......ss	..................plsVlGG.Gh.l....Gl....Eh.A.thh.............................pp..h..G.................s.......c..V..o.....l..l...c.t....t..s..........p...l.........h..............................h...........s.......................p......h...........s...........p.......h..........h............pc..p....h...p..pp...............G.l...pl..h..h..s..s....p.l..p..p.lp........tss.t..t.......l.....tttt.............................................................	0	3391	6626	8921
+763	PF02852	Pyr_redox_dim	pyr_redox_dim; 	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	Griffiths-Jones SR	anon	Structural domain	Domain	This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.34	0.72	-4.03	102	18533	2009-01-15 18:05:59	2003-04-07 12:59:11	17	94	4904	322	4408	13761	3778	109.20	27	23.24	CHANGED	lPsslaopPElAsVGl...TE.ppApppsht......lcltphsas..........sss+Ahshtp......scuhlKllsct.cspclLGsHhlG.spuuE..hIpthulAlchuh...Thp.-.hspsltsHPThuEthtpss	.....................................lPtshaopP.pl.AsVGl....T....E....pp....A....+....p....p..s.hp................hcstp..h..sas.......................s...s.+..A...h.shsp...............spGhh.Kl.l.......h......c.............t.....c......o.......pc..llGsph...l..G........s..u.sE....hIpt...hul...Al.....c..h.s.h...ohp...p..h..sp..sla.sHPThuEshh...h.........................................	0	1486	2777	3700
+764	PF01729	QRPTase_C	QRPTase; 	Quinolinate phosphoribosyl transferase, C-terminal domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2063 (release 4.1)	Domain	Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other.  The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.98	0.71	-4.73	18	3824	2012-10-03 05:58:16	2003-04-07 12:59:11	14	9	3313	84	1170	3336	1907	167.10	40	57.32	CHANGED	IATtTpchlctscus..ps+lhsTRKTtPG.LRhh-KYAVhlGGGs.......sHRhGLsDslhIKDNHIsssGu...lpcAl+psRphs.shs....lEVEl-sL--hccAlp.........uG....ADlIMLDNh.........ss..-pl+cAlc.h.ctpshc....hhlEsSGGloh-sltpaApsGVDhIShGsLT+uspslDlSLc	..................................................................................lAThTpphVct.lpus................pspl.hDTRKT.h.P...G...L.R..h.h.p.K..YAVhsGG.Gh................NHRhGL.....sDul.......LlK-....N....HI....t....s........s......G..u........................l.pp....A...l.ppA...+t...ht....st...h...s.........lEV...E.V...-...o....L....-.....p.....l.c.....-..Alp.....................................AG...........AD..lIhLDNh........................ss......-ph.+.....c.A.....V.p.........h..h..ss+...........shlEs.SGsl..oh.cs..............lpp..h..A...p..o...G...V....DhISlGu...L.T...+...ss.pslDlShc........................	0	388	754	980
+765	PF02749	QRPTase_N		Quinolinate phosphoribosyl transferase, N-terminal domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2063 (release 4.1)	Domain	Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other.  The N-terminal domain has an alpha/beta hammerhead fold.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.54	0.72	-4.16	161	3866	2012-10-02 20:27:15	2003-04-07 12:59:11	11	8	3303	80	1158	2967	1621	88.60	32	30.01	CHANGED	hs...tG.DlTo..shlsssppup...uplhu+ps.ullu.Ghphspp.lachl....................sl.plp..hhhpDGcplpsGs........hlhplpGsucslLpuERsuLNhLp+hS	......................................sDlTs.....tll...s.s..s.p.p...up....upll..s.+..-.s.GV.l.u...Ghp.h.sp.p.lFptls........................................ssl.plp.......hthp...DG-tl...ps..sp..........................sl..hp..lpGss+sLLsuERsALNhlpphS............................................	0	387	749	973
+766	PF01424	R3H		R3H domain	Bateman A	anon	Medline:99003905	Domain	The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues.  The function of the domain is predicted to be binding ssDNA.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.15	0.72	-4.27	402	3275	2009-01-15 18:05:59	2003-04-07 12:59:11	17	89	2043	7	1332	2719	355	63.80	24	13.76	CHANGED	cppplpphspphhpps....h........pss...p.........shphp.P..h.ssh-R+.llH.phsp....th.....s...lpopS..t.......G.pt.sp..Rplllthp	...........................................................l.phspchhppl....h.....................css.........c..........shphp.P.....M..sshER+.l.........lH.phsp...hh.....s....lpopS.....p.........G...cc.sp...Rtl.ll......................	0	444	749	1050
+767	PF03834	Rad10		Binding domain of DNA repair protein Ercc1 (rad10/Swi10)	TIGRFAMs, Griffiths-Jones SR, Coggill PC	anon	TIGRFAMs	Family	Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain.  Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex [3].	22.10	22.10	23.90	23.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.48	0.72	-4.28	26	301	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	268	3	216	287	4	67.50	46	21.96	CHANGED	psILVsspQ+GNPlLpp..l+slsWca.s.-....IlsDYhlGpspslLFLSLKYH+L+PEYIapRlcpLpp.pash	...............sIlVu.sR.....Q+GN.PlLpa..l+.s..ls.WEa.u..D.....I.s.sDYll.....Gpo.oCsLFL.SL+YHpLH.P-YIapRlcpLsppat.h........	1	73	120	178
+768	PF04423	Rad50_zn_hook		Rad50 zinc hook motif	Bateman A	anon	Bateman A	Motif	The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.55	0.72	-4.50	32	262	2009-01-15 18:05:59	2003-04-07 12:59:11	9	18	230	2	157	265	13	53.50	26	4.97	CHANGED	phcspttphpctlpplppspt..sCPlCtRslss-cc.pclhpchppclpph.cchp	.............htttht.hpphlppLsc..ppt..sCPlCpRshss-pc..pcllpchpsclcth.cp..................	0	38	69	121
+769	PF04055	Radical_SAM		Radical SAM superfamily	Bateman A	anon	Bateman A	Domain	Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.	29.40	29.40	29.40	29.40	29.30	29.30	hmmbuild  -o /dev/null --hand HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.13	0.71	-4.08	628	65493	2009-09-17 13:13:13	2003-04-07 12:59:11	16	316	5136	37	18526	49841	14153	169.40	14	43.97	CHANGED	h.hsssCshp.....CtaCthtt...............................................................htttttthshcplhchhcph...ph...hp.tlhhs.....................uupshhh................................hshhthhhthttt.............................................................thplslposshhh............................tchlctltchs...........hstlslslcshspp.........................htchh...pttsh........cphhcslcthpcts......hp...........hhshhhhh.sps.p..pchtphhchl	............................................................................................................h..hhttCs.hp...........C.s.....a.......C.thst.......................................................................................................................ttt.pths...h.....c........c....l......h.......p........p........h.........p.........p........h..................h.........p.....................s.........h.........p........t........l..h..h.s..................................................G.G.p..s..t.h..h.........................................................................................................h..s..h..h..t..h....h.h.thtpt.............................................................................................t..thc..l..s..l...p..o..s..sh.h.h...............................tchl.p.t...l.tp.ts................hs.h.l..p..l...s..l...p...s...hspp..............................................hhphh......ptt..sh....................pp....h.h....c.s...l...c....t...h....p..p.t..s...........................h......................hh.hh.hh.h........s.....s........p..ph.......h.............................................................................................................................................................	0	6768	12613	16003
+770	PF02145	Rap_GAP		Rap/ran-GAP	Mian N, Bateman A	anon	IPR000331	Family	\N	21.50	21.50	21.60	21.50	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.25	0.71	-4.92	54	1221	2009-01-15 18:05:59	2003-04-07 12:59:11	10	45	216	7	719	1143	3	181.80	35	14.83	CHANGED	lhsNppu..S..sapcFLshLGpp.................................VpLps..ap.tapGGLDspss..psGpao....lYhphc.........spElMFHVoThhPh....sts...............DtQplp+KRHIGNDhVsIlF....sE.ssps.as..................................shItSpFs...alhlllpsh....................ps...................................................hY+Vplhp+...sslP..FGPhhs.sthl.p..c..shtsalhspsINAppsshph.....spasphh..pcph.phlc.......sL	................................hhsNppu...S....sap-FLs.hLGpp.................................lcLcs.....ap....ta.p..G..GLDs.p.ss..pTG...ppo......h.Y..hs..h.p.........shElh..FHVSThh..Ph....p.ps......................cp.pp...lp.........+KRHIGNDhVsIVF.........pE....ssp...s....Fs.................................................................sh.I..t.SpFp.........alall..l.ps..ht...........................s...................................................................................................................hYpVsl.p.p+.......p-..VP.....hFGP..s.....hs.....s...s...hl..t.+..........thtpalhsphINAppAshps..........tpatphh..p..cph.thlcp...........................................................................	0	262	341	531
+771	PF04078	Rcd1		Cell differentiation family, Rcd1-like 	Wood V, Finn RD	anon	Pfam-B_5278 (release 7.3);	Family	Two of the members in this family have been characterised as being  involved in regulation of Ste11 regulated sex genes [1,2]. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation [3].	27.60	27.60	27.80	28.90	24.60	27.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.59	0.70	-5.56	27	453	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	304	4	291	421	6	238.70	58	77.46	CHANGED	phltcLt.pPcp..REpALlELSK+REpascLAshLWpShGslusLLQEIlulYPhLs.........PPsLos..ttSNRVCNsLuLLQCVAS.Hs-TRthFLpA+IPLaLYPFLpTsu+sRs..FEYLRLTSLGVIGALVK.sDcsE....VIsFLLpTEIlPLCLRIMEhGoELSKTVATFIlQKILhDDtGLsYlCtTsERFhuVupVLspMV...tpL...spps.os........RLLKHllRCYLRLS-Ns....................RA+cALpphLPptL+..DsoFsshlc-..Dsss++hLtQLLhNlsst	........................................hl.-Lh.sspp...REsALLELS....KKR..E.p....hs-.LA.hLWaSF...G............shsuLLQEIlslYPh.ls.........Psp..Lou...ttSNRVCNALALLQCVAS.Hs-TRshFLp.................A...............HIP.LaLYPFL.pTsSKoRP..FEYLRLTSLGVIGALV.K..sDsp-.....................VI..sFLL...............sT.EIIPLCLRIM.E..s.G.SELSKTVAhFIlQKILLDD............s..........GLsYICtTh.ERFh.tVutlLupMV...hpL............scps....os..............................RLLKHllRCYLRLSDNs....................RARc.AL+.p.CLP-....L+.......DsTFs..psLc-....DssTK+hLtQLLhNlp.s.....................	0	108	166	239
+772	PF05177	RCSD		RCSD region	Guo JH	anon	Guo JH	Family	Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.	25.00	25.00	27.70	25.50	19.50	23.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.14	0.72	-10.92	0.72	-3.52	4	51	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	16	0	36	64	0	87.60	41	11.71	CHANGED	cV+SPsKKEKSP..............EKoEpp.so......EEsKos..KEKSPEcsDtp.tSPTKK-KSPppSusE...-lKSPsKKEKSPE...KsEccPuSPTKKE............psppcEKSPE	....................................................tKp.pp....tss......EcsK.sspK.cc+S..sEc.s.-c...pshSPs.KK-K.SPppS.usE......cs+SPsccctusE...csE.c..uo.sKcE.......................p..................	0	7	13	33
+773	PF01030	Recep_L_domain		Receptor L domain	Finn RD, Bateman A	anon	Pfam-B_244 (release 3.0)	Domain	The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix [1]. This Pfam entry is missing the first 50 amino acid residues of the  domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.71	0.71	-4.10	68	2555	2009-01-15 18:05:59	2003-04-07 12:59:11	19	86	174	80	1269	2434	30	112.50	25	20.58	CHANGED	sCohlpG....sLpIphtstp......................t..thlsslcclsGhlhItps..thpshshhpsLchIcGpphhp......paulhlhpN.p...............LpcLth.s..LppIpp.........GslhlppNs.......cLChtpp.h.hphlh	.........................................................sCohl..p.G.....sLplh.hstp........................................phphh..p..slcclo.....Ga..lhIpps......thss.h.s.hhp.N.Lph.....I.....+..G...p.p..l.hp.........................pau..Lhlh.pstp.............................................LppL.t.h..s......L.p.p....l.p..............................Gtlh.hp.p...N............pL.Chhp.p.h.h....h.................................................................	1	289	375	1023
+774	PF02010	REJ		REJ domain	Bateman A	anon	Bateman A	Family	The REJ (Receptor for Egg Jelly) domain is found in PKD1 Swiss:P98161, and the sperm receptor for egg jelly Swiss:Q26627.  The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.36	0.70	-6.17	25	1075	2012-10-03 16:25:20	2003-04-07 12:59:11	10	184	317	2	592	1109	109	274.00	15	21.55	CHANGED	Aplpl..pC....sstpspapWplhsssssssh.phsp.....................t..plsIPphsL....hGsYshsholoh.....sssslsspptsplplts.....osLhAhIcGGopcshuhp..pslh.........lDu.SpSh...DP...........Dhsstp...sslsatWhCpspsss........................................tsC..........t.t.h.hssssuslolsuspLpussp.YpFplslsKsu.....R.oupoppslhlhpGpsPplplpChssss.t...lssssclsLpusss.sss...sppspapWsl...........ps.tt..hh.....................................................................................................................................................................................................upssTshssstLsl+tsshpsstpYthslhltssshpt......hAshshps..NtsPpsGsCsl............sPspG...hsLpTpFslpCpsapDp-t.......PLsYphhh.............hpsps.hphlhpGspspp.....thhLPsG.ssp.taslslhVpVhDshGuss.ssshslpVpsssssss.........hh.hh.tssstlsshltpGDstputphhss	.............................................................................................................................................................................................................................................s.........h..htl...........................t...h..spt.h.......l.....l.........................t..s.............s.h..h.....s.s...s....t.hh.hshs.......psl.s...........................................Ls..G..otS.......Ds...........st............lp..apWppss.ssts..................................................................................................................................................t..tp.s.sh....hph...sp.h.....t......st.......hpF.p...lplpcsp.................t.sstsph...sl..h...s.............t.......................h........................................h...t.......h..h.h.....t.....................h.....h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	318	363	454
+775	PF03432	Relaxase		Relaxase/Mobilisation nuclease domain 	Finn RD, Mifsud W, Bateman A	anon	Pfam-B_4002 (release 6.6)	Family	Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalysing  trans-esterification[1].    	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.43	0.70	-4.98	17	2990	2012-10-02 18:54:05	2003-04-07 12:59:11	9	15	1395	0	379	2707	170	226.00	16	49.85	CHANGED	spsShsphlsYhpp...........................+shppsshp...hsschstpphhsspthas........cs........psspsacll.SFpssE..ss......cphppluhchhpplu..saQhhlhsHsD....p-plHsHIllNplchpo...G+phpsp............h..shcplccsscplspccGhphspt........st.+.s.s-tshhp.......................scsphctph+pslcptpt....spsap-h+ctLpcpGlclc..thsspplshphpspp..ppl+usplucc..ascsplcpchtcp	.......................................................................................................t.....................................................................................t..h..............p.....h..................t.....t..........t...............................................pt.......................pt..sh..H.hhhSap...s....t.-...hss....................................cph....p....p....l....u.p....c......h....h....p...c..h.........t.....h.........s......p......a......p........a....l.lsp.H...p.D..............ps....+.......hHhHIlh.s.pls..pt...............G..+ph..p.sp............................................h....shcp.h...p..p.h...s...c.c..l.p.p....c...h.Gl...phspp......................t...p..p......p....h....t...pht.hhp..............................................................................................ttt.p...h...c..t..t...l...p.p.....t...lp.thht..........t..psh...p.p...hhp...h.h.t.p.....s.h..plp............tt....t...............h..............h................t..............................h....p...p..t..h.ttt....h.............t.......................................................................................................................................................................................................	0	137	269	341
+776	PF03090	Replicase		Replicase family	Mifsud W	anon	Pfam-B_2424 (release 6.4)	Family	This is a family of bacterial plasmid DNA replication initiator proteins. Pfam: PF01051 is a similar family.  These RepA proteins exist as monomers and dimers in equilibrium: monomers bind directly to repeated DNA sequences and thus activate replication; dimers repress repA transcription by binding an inversely repeated DNA operator. Dimer dissociation can occur spontaneously or be mediated by Hsp70 chaperones.	20.10	20.10	20.10	21.20	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.56	0.71	-4.31	15	361	2012-10-02 15:26:12	2003-04-07 12:59:11	12	7	242	0	25	357	7	124.40	36	38.95	CHANGED	sulhhps+psALcp+YIQsNtsphsshLVhDlD+s..sA..............ththtctst.sPNhhstNssNGHuHLlasLs.PVpss-t.ARpKPlpYhAAlppuLpptLsuDhuY.SGLlsKNPtHs.......pWpspphpsc....YsLccLuchL-	..........................h.thhhts+thAlt.h.YhQhNp.sthhtaLVaDlD+t...su.................lsWp.-tshPsPshhsp.......N.p.s...G......Hu..pLhYuls.s..V.p.....ss.....ps.....ucsKslp.....YhtAlppuhst.+L...s.A.....DssY.uGhlsKsPhHs.........................tWpshchppcs...YpLs-LAshl-..........................................	0	6	14	24
+777	PF03248	Rer1		Rer1 family	Bateman A	anon	Pfam-B_3358 (release 6.5)	Family	RER1 family protein are involved in involved in the retrieval of some endoplasmic reticulum membrane proteins from the early golgi compartment. The C terminus of yeast Rer1p interacts with a coatomer complex [1].	21.60	21.60	22.10	22.20	19.90	21.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.21	0.71	-4.69	34	427	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	311	0	286	395	2	163.90	50	84.44	CHANGED	sslsphhp+hpppYQphLDcosPasthRWhshshLlhlFhlRlhhhp.GWYlVsYuLGIYLLNLFLuFLTPKhDPuLpppp...t.-tG................LPt................cps-...EFRPFIRRLPEFKFWasss+AhhluhhhoaFshFDlPVFWPILlhYFIlLFslTM++QIp..........................................HMIKY+YlPFshG.Kt+Ystp	...............ss...thhscltphYQtaLD+.........oTPasthRWlsshslhhl...ahlR..lh........hhQ.GaYI.........VsYuLGIYlLNLFlAFLoPKh..DPslptpp.....ptGs..................sLPo...............................+ps-...EF.RPFIRRLPEFKFWausT+.AhhluhhhTaFph....FslP.VFWP...ILlhYalhLFslTM+RQIp..........................................HMIKY+YlPFshG.Kt+Ytt.p.............................	1	98	166	240
+778	PF02453	Reticulon		Reticulon	Mian N, Bateman A	anon	Pfam-B_2196 (release 5.4)	Family	Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.94	0.71	-4.65	90	1346	2009-01-15 18:05:59	2003-04-07 12:59:11	12	20	297	3	619	1288	1	158.90	25	44.60	CHANGED	ssDllh.WRch+touslhuushs..hLhp.l..tphsllolhspl.hlhsLssshshphhtpllps..............h...clslsc-thpphssslhthlNpslppl+clh...hsc-lhpolp.hsshhallohlGuhhshhTLlhluhlhhFolPllYc+apcpID...phlt....hspsplpc	.........................h-llh.W+ch+..t..ouhlh..uushh..hLh..p...l.....hthol....lolhuhl...hlhhLs.sshs....h...p..l..h..p...p..llps..t............................ht....pls.l.sp......-.....t......hp.......phsss.l..htpl...Np...slttl+.c..lh...hsc...D...h...h.p............sl............p...h.s..l.h.h.a...llohl.G.u..hhs.sl.TLh.h.luhlhhao..lP.h.lYcc..hpspIDphlt.......hsppph..p........................................	0	125	283	450
+779	PF04527	Retinin_C		Drosophila Retinin like protein	Waterfield DI	anon	Pfam-B_4914 (release 7.5)	Family	Family of Drosophila proteins related to the C-terminal region of the Drosophila Retinin protein. Conserved region is found towards the C-terminus of the member proteins.	22.20	22.20	22.50	22.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.51	0.72	-3.98	18	168	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	19	0	91	157	0	73.70	44	54.73	CHANGED	lhpEPsVA+VGslV+slPoAVSHQSpT.VHs.pt.lhpPVl......APsVKsT.lhp....sPl..s.........................tAAPll+s	................llpEPslA+VGs..V..V+olPo...AVSHQStT.VHs.pt.llp.PVV.......AP..lVKoT..hhs......uPllts......................tuAPll.....................................................................................	0	17	20	58
+780	PF03732	Retrotrans_gag		Retrotransposon gag protein 	Finn RD	anon	Pfam-B_3194 (release 7.0)	Family	Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.19	0.72	-3.92	57	4914	2012-10-02 13:37:57	2003-04-07 12:59:11	12	294	205	0	2568	5331	10	92.40	19	10.14	CHANGED	phhshtLputAtpWapslhsspht...............oWpphpptFhppahs.tphsphppclhslpQ.sscolpEYhpcF.cplhppss......hsc...................pshlptahpGLpt	...........................................................h.htLp.s..A.t.tW.h.p..p..h..ppht..................................oW...p...c..h.p..pt.F...hpp.F......h..s...s....t...tt.s.t..t..c..p.p...l.p...s...l....p..Q..s...sc..ol.p-Yh.pcF..p.p..lt..p.ths..........hsp..........................t.hh...th..ah.tGh......................................................................	1	853	1171	1588
+781	PF01694	Rhomboid		Rhomboid family	Sohrmann M, Bateman A	anon	Pfam-B_1399 (release 4.1)	Family	This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes.\	\	Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor.  Analysis has shown that Rhomboid-1 is an intramembrane serine protease [2][3][4] (EC:3.4.21.105).  Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite [5].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.89	0.71	-4.17	65	7854	2012-10-01 23:21:32	2003-04-07 12:59:11	17	73	4018	16	2797	6356	2105	148.00	23	48.95	CHANGED	shtpsphWR.....llTshalHs..hhHlhhNhhsLhhhGh.lEphh.....GphRhhhlYlluGlhu...ulhshlhssts......................tlGASGulaGllGuhhshhhhshhhhh................................hhlhhhhhhlslshshsh...hstlshhu...........................HluGhlsGhhhuhhlhtthp	....................................................h....phaR......llo...sh.F..l...H.........h........u...........h.......h.........Hl..hhNhlh....L....h.............h.....h.Gth....l...E....p...h..h......................G...p.....h....+h......h.h....l...a.l.....l...uu...l..hu..........ul.h....p....h....h...hss.s............................................................hlGASG..u.....l...a....Gl.....h.us.h.h..h...h..h.h...t.s.t.t.h.hh..........................................................hhhhh.h.h.h.h.h.....l..h.h..sh.h.hsh.............hs...s..l..s..hhu............................................................Hl.u..Ghl...s..G..hhhuhhh.....hh.............................................................................	3	991	1753	2345
+782	PF05104	Rib_recp_KP_reg		Ribosome receptor lysine/proline rich region	Finn RD	anon	Pfam-B_3249 (release 7.7)	Family	This highly conserved region is found towards the C-terminus of the transmembrane domain [1]. The function is unclear.	25.00	25.00	25.80	25.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.36	0.71	-3.69	6	77	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	30	0	24	79	0	127.50	54	14.53	CHANGED	MKETSYEEALAKQRKEpuKTQ.ptKsDKKKK-KlsEKKsKuKKKEEKPNGKIPEpEsstEsocp........llltppP..sPsVsssPspVsls...PsVAshPcsotPs.opcpsuuP...tKuss..sPpspppKppKsA....KstPAPsptussP..hsuKuAPlsAp	...MKETSYEEALApQRKEhuKTp.ppKs-KKKK-K.ssEKKsKsKKKEEKPNGKIP-p-ssspso..........................lh.ppP...sPsVslsPssVt.........s.lh.tPhsssPs..s.pcchsus...........Pp.cpppKp.pKs.A........KscPAsuphsss..h.ssKuA.h...s.............................................................	0	2	6	11
+783	PF00636	Ribonuclease_3		Ribonuclease III domain	Bateman A, Finn RD	anon	Prosite	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.55	0.71	-3.63	239	3186	2012-10-03 08:45:47	2003-04-07 12:59:11	21	88	1836	63	1255	5519	1999	113.60	26	26.36	CHANGED	ppLtaLGDullchhlpphlh...........................tspLsp........h...psthV....sspshu..phsp............p.......................................L...tp....hlp......................................................................................................................................................................t...................phhusshEullGslaLsss	...........................................................................................................pLtal.G....DAl..hchhlpp.aLht........................p........sph..c.......................sspLpp.........h....ps.phV.......ss.cs.Apl.h.t..........................p........................................................................hh.......................h..pp........hl.p.p...pp......phhcptcs..................................................................................................................................................................................................................................................................................tpt.tt..p.......pssht.sh.phu..sshEAllGhlalst.t................................................................................................................................................................	0	428	728	1043
+784	PF04597	Ribophorin_I		Ribophorin I	Kerrison ND	anon	DOMO:DM04452;	Family	Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC:2.4.1.119).  OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum.  Ribophorin I and OST48 are though to be responsible for OST catalytic activity [1]. Both yeast and mammalian proteins are glycosylated but the sites are not conserved.  Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function [2] Most family members are predicted to have a transmembrane helix at the C terminus of this region.	25.00	25.00	27.80	25.30	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.41	0.70	-5.97	40	386	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	288	0	244	366	1	397.90	32	80.96	CHANGED	sacNssltRsl-Lspsal+pohplslc.....Nhu...spP.tscYhhshss..c.hspluhlssp.ps.spttsph........slclppsp..t...........aplpLPpP.ltPusplslplp.ashspslpPhPspIsQs-pQhlhapssta.hhSsYtTcp.Qphpl+hs.sspl.saTpst.............sspppssslsYGPa..pslsu......aohpP.ltl+YEpspPlsplspLpRsIEV..SHW.GNlshEEpYpLpNsGAcLputFSRl...-appsphp................................................sssulpplchhLPs..supDhYYpDplGNlSTS+hpsspt.h.....................Lcl+PRaPlFGGWpasFslGashshppaL+psust..pYhLplPhlsuhp...-shh-plplcllLPEGApslclps.........P.hshtptphshchoYLD.ThGRsslslphpNls...--tp.pplhVpYca.......sthshhpKPlhIsuhhahlFluhhllsp	.............................................................................h.s.sl.RplcLpp.ph.s+.shplhlp........shs...sps...spah.hsh.s........p..hspluhlpst.pttpptt................hphtt.tp..th.......................................................aplpLsps.ltsutphslhlp.hhhspslpPhPtpIsQ.s.-..p.Qhlhapssta....hhS.sY.Tpp...Qphpl+hs...ospl..s.aTphs..................................sspppssplpYGPa...cslss........ho.ps..hpl+aEpspPhhslsplp.R.sIEl.....SHW.GNlulE...Ephp.LppsGApL.cusFSRh...-appp...t................................................shsulpphchhLPs..uup-sYYpDpIGNlSTS+hh.tp.cpsp....................l-l+PRaPLFGGW+hpahlGYshP..........pa.Lhptss..........pahLph.hlstlh...sh.sh-plpl+llLP.............EGAcslclps...................P.hslpptt....p.h.chTYLD..ohGRsslshptpNll....-pah..ppl..hVpYsa.......st.hhhLp..cPLh.lsu.shahlFhsshlhh..............................	0	87	140	202
+785	PF01775	Ribosomal_L18ae		Ribosomal L18ae/LX protein domain	Bateman A	anon	PSI-BLAST Q02543	Domain	This family includes eukaryotic L18ae as well as archaebacterial specific LX.  Ribosomal protein L18ae forms part of the 60S ribosomal subunit.	22.90	22.90	23.50	22.90	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.37	0.71	-4.23	63	714	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	512	7	414	682	35	104.30	44	66.40	CHANGED	l+pYpVhGchhss...........................................................................................................................p..................hsshcshhKEhRshsppsAl-phYs-hGu+H+s+tppIpIhcVp	............................................................................ppYpVlGRtlPo....tt.t..s.la+M+lFAsNplhAKS.....................................................................+FWYFlppL+KhKKusGEllthp..l..............................hE+pPhplKNa...G.I....W....l.R.Yc...SR.oG.p.HNMY+EYR-hohsuAVpphY..........p-MuuRHRsRhp..sIpIl+V..........................................	0	140	231	342
+786	PF00828	Ribosomal_L18e		Ribosomal protein L18e/L15	Bateman A, Finn RD	anon	Pfam-B_1295 (release 2.1)	Family	This family includes eukaryotic L18 as well as prokaryotic L15.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.86	0.71	-3.77	104	6291	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	5075	302	2015	4096	2465	118.70	35	75.86	CHANGED	Ghhtppct+sp+ut+sp........ppc.ha.th.h....la+hlu+.+....sFpp.hh...hhsphphssl...........................Nls+L.p..thhtts.........ssc.hllshuhl.......ts.hKlLGtGtl..phs.lsVpAhphScsAcp+IcpAGGpshhh	........................................................................s...GKTuGR..GpKGQ+uR.uGs.......ts+h......GFEGGQhP....LaRRLP.K.h...........GFss.hh...........phs.V....................................NLscL..s...p........t..ps................ls.p..sLhtsullt.......................tshlKl.L...u.........s...G............c......l...s........p.t....ls.V.c........u........t.phS.cuAcpt.Ic.uAGGplp..h...................................................................................	0	703	1254	1677
+787	PF01907	Ribosomal_L37e		Ribosomal protein L37e	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes ribosomal protein L37 from eukaryotes and archaebacteria. The family contains many conserved cysteines and histidines suggesting that this protein may bind to zinc.	24.50	24.50	24.70	25.00	23.00	24.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.92	0.72	-4.17	46	667	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	505	75	372	579	23	50.80	56	57.37	CHANGED	sKGTsSFGK+pp+.oHhhCRRCG+pSaHlpKcpCAuCGassu+ph.pYs.WspKshc	...................sKGTsSFGKRpsK.oHsLCRR.C.GR+SaHlQKpsCuuCGYPuu+pR.cYN.Wu.KAh................	0	138	223	305
+788	PF00347	Ribosomal_L6	L6;	Ribosomal protein L6	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.30	21.30	21.40	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.42	0.72	-3.48	132	10746	2009-01-15 18:05:59	2003-04-07 12:59:11	18	5	5013	462	3006	6705	3987	74.40	26	80.83	CHANGED	lshG.hclphps.....plhhshG.pt....lphphsps.lplph......phshhhh.puhc+pp.........ltphRshhs.hs+Glp.G	..................................lssG.hc.s.phpG...........pllhshG.p.ts..........lphp.h.s.ps...lpl.....p.h.......................................p........h....s........hhh....h...p.........G...t...c...+.phs...................thtshRs..s.h.scGVp..........................	0	982	1857	2473
+789	PF02482	Ribosomal_S30AE	Ribosomal_S30;	Sigma 54 modulation protein / S30EA ribosomal protein	Mian N, Bateman A	anon	Pfam-B_869 (release 5.4)	Family	This Pfam family contains the sigma-54 modulation protein family and the S30AE family of ribosomal proteins which includes the light- repressed protein (lrtA) (Swiss:P47908) [2].	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.14	0.72	-3.55	144	5238	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	4060	21	1172	2968	717	96.10	30	63.58	CHANGED	plploG..+p.l-lo-ul+palpc+ls+.lp.+ah.s....ph...hp.sc..Vhlsht.........t....ptpsElol.hh..sGh..hlpAps.pspDhYuAIDhss-KL-+Ql++aKc+..hp.s+	..................................hsIpG..+p.l-.lTcA.lRpaVppKl..s..K..LE..+ah..s...pl......hp..sc...VhLps..............pp.p.stp...sEs..Tl...h...sus..........hlp......A......p..........s......p.........s......p....D.......hY....u......AID....hlh-K....L-RQL....pKhKcKhpp........................................	0	368	735	983
+790	PF01201	Ribosomal_S8e		Ribosomal protein S8e	Finn RD, Bateman A	anon	Prosite	Family	\N	21.30	21.30	21.60	21.80	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.67	0.71	-4.01	93	1149	2009-01-15 18:05:59	2003-04-07 12:59:11	17	11	591	7	655	1075	110	194.20	35	92.35	CHANGED	Muhscs..cp+R+tTGG+hcht+K.KRKaEhGRs.....................................................ss.T+l........u....tcl+plR.........................sRGGNp.KhR..............................uLRhcpuNhsasppssoc+s+IlsVhhNsuNschlRpsslsKGsIlplsss............-LG...............................................................................hAploSRPGQ...............sGhssuhll	.......................................Ms.sc.t.pc+R+tsGt.+hchhcK...KRKhEh.G.cs...................................................................sssTpl............up...ppl+phR...................................................................sRGGspKh+.................................................ALRhcpuNho..asptssTt+scIlsVhhNsSNsphsRpssL....sKusIlplsss............pLGhhttst...............................................................................h..hthhAploocPGQ...............sGpssuhlL..............................................................................................................................................................................	1	231	377	536
+791	PF00652	Ricin_B_lectin		Ricin-type beta-trefoil lectin domain	Bateman A	anon	Prosite	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.45	0.71	-4.09	97	3906	2012-10-02 19:42:32	2003-04-07 12:59:11	17	272	770	168	1967	4763	232	120.80	19	22.78	CHANGED	ssshlpths..sshCLDst....tttpsssltlhsCss......sss..QhW...phsts......splpstst..........CLssssss..............s.ltlhsCps.ssst......QtWphps........ssplhstp.ss..hCL-stt.......sssplhlh.pC....sss....ss.QpW	...................................................................h.....t.ht...sshC..l-st............ttsst......l.t...lh.....s.Cps..............sss.......Q...h.a............th..s.t..s....................t....p....l...p...t..t.s...t...........................C...Lssssts..................s......l...tl..h.s.C....s......s...sss................Qp..W.phps.....................ss..p..l..h...ph....t..ss........hCLsstt.................sstt.l.hl....t...C....sts......s..QtW.............................................................................	0	706	1030	1517
+792	PF00355	Rieske		Rieske [2Fe-2S] domain	Finn RD, Griffiths-Jones SR, Eberhardt R	anon	Prosite & Pfam-B_31 (release 4.1)	Domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.08	0.72	-10.67	0.72	-4.42	146	13057	2012-10-02 12:49:59	2003-04-07 12:59:11	21	95	3458	318	4393	11916	6165	94.20	19	31.33	CHANGED	sahhlsppsclsp....sshhhhph.spp.llht.stcGphhuhtshCsHtGsh................lsts....tp......t......hpCshHGhpashp....GplhpsPs................hpth.sthphs	.................................................................h...tpl.t............t.h..h.h...h........h....s....t.....t.........l..h...h...h....s........t.........s.....u...p.........l..h..uh.ts.hCsH..t..G.s........................................................lst..s.....ttp..................tt.............th.hCP.hH...G.h....pash.....s......Gph....h.p....s.Ps..t............................tt.....................................	0	1183	2635	3671
+793	PF00866	Ring_hydroxyl_B		Ring hydroxylating beta subunit	Bateman A	anon	Pfam-B_771 (release 3.0)	Domain	This subunit has a similar structure to NTF-2 and scytalone dehydratase.	20.50	20.50	20.50	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.64	0.71	-4.51	44	1346	2012-10-03 02:27:23	2003-04-07 12:59:11	13	2	779	109	317	1106	162	141.90	28	83.48	CHANGED	+EAcLLDs.....pcacpWhs.lhs-DlpYahPhppsc.ptsps............ptshhas-s+ttLcsRVtRlposhuWupsPsoRTpHhloNl.ltts.psssplcVpSsahlaRsRhc...tpschasGpppchLRpsssu.....hclspRpllLcpssl.sp	...........................................................pEApLLDc.....tcaccWLs.hhs--...h.pYhhPspss....ttphspc.th................hshla.p-s+stLccRlhRl.c.o.shua.u.p.p.PssRT.pHhl.oNlp...l...h....pt.....t.......p.....s...s....t...........hp.VRsNahlh.c.sRtc...........p.ps.h.a.s.Gpp.h.cplccss-s.........h+lhc+pllLcpshltt...................................	0	51	148	245
+794	PF04068	RLI		Possible Fer4-like domain in RNase L inhibitor, RLI	Kerrison ND, Finn RD	anon	COG2042	Family	Possible metal-binding domain in endoribonuclease RNase L inhibitor.  Found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, fer4, Pfam:PF00037. Also often found adjacent to the DUF367 domain Pfam:PF04034 in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons [1], and could possibly play a more general role in the regulation of RNA stability in mammalian cells.  Inhibitory activity requires concentration-dependent association of RLI with RNase L [2].	20.60	20.60	21.20	21.20	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.63	0.72	-4.36	80	889	2012-10-03 08:56:42	2003-04-07 12:59:11	10	13	472	2	602	859	65	33.10	36	7.40	CHANGED	h+lAllch-....cCc.PKKCst.cht+hssl......s+sGcp	..........+lAlhsh-................+Cc.PK+Cst.cht+hs.l......lRhGp............	0	200	348	505
+795	PF04437	RINT1_TIP1		RINT-1 / TIP-1 family	Bateman A, Wood V	anon	Bateman A, Wood V	Family	This family includes RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control [1], as well as the TIP-1 protein from yeast that seems to be involved in a complex with Sec20p that is required for golgi transport [2].	24.80	24.80	25.20	25.10	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	494	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.68	0.70	-5.95	19	318	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	250	4	239	330	2	430.90	22	62.61	CHANGED	hsl-hhlpPlclRFpYHFoup+.Tspl-K.PEaahshlhchlss.ssFhspplQPlhDc........hthshhss+ppFIsull.hlpcKlsspl..................plppc.phhsHLlcEllsFDpcl+psasY.s...............h..slplLs.cpsha-+WlplEcchAls+hcthlps.cshphp.pt.............l.sshssh+sscsAtph.cLLpslh-RhpsLsshs.clpFLhslQlplhcpFhppLppth.th.h................tphpssssL.+hspllsuspYlpphlc-WuscVaFl......p.t...............phscluscsou..................lFD-shsshc+.lchchpshIssslhcshcsth+sYh+.hspWsohssp......stt.shssSu.-lssshphLpsplshLppt.Lshsshtplh+plhtslppalassllhts.pFSpuGusQhthDh.cpLhslhsh..........stpspthhp+LsEulhLLsLphsts...tphh.tt.tc........................spsspshLsEl..ulppLop.........s-spslLpRRs	...............................................................................hshphhhpPhthRFp...aHF.p.u.p.+...Tshhs......K.....P.....E.....aahs.lhphhpph.thhtphlpshhsp..........................t.....h.ss.h.pa..hpull....hlhpKltt..l.....................................................................p.h.tps..thhsHhlpphhtF-pp.lp.......ph....asYss.......................................................s.shplL.....ptp..h....h..ppWlphEpc....hAhp+hp.t.h.h.ps....ssh....p...p...........................t..s.ph+..ss.sA.phhpLLpslp..........c+.apsL.phs.clpFl.plQhtllcpah.pLhph................................................................tt.pt.sth.phstlhsuspaltphl...p-Wup..p.hhFl............................p..............................thtphss.ptss.....................................................................lF-phhs.hpp.htpph.p.lhp...tlhpphptth..+sYhp...ppW..sh.tt................................hs.Ss.phs.hlt..hLppplt.Lppt.Ls.hs..........hhth.hptlhptlsphlhp.pll....h......ts...pFst.........sGstQhthDh.ps..lhslhp....................ht...p..s...p...thh.pl.p.-uhh.lLs.h..ht.t..................t....t...................................................................................hpthhtph....t.l.t..ls..........tph..lL.hh....................................................................................................................................................................................................................................................................................................................	0	83	134	198
+796	PF01163	RIO1		RIO1 family	Finn RD, Bateman A, Wood V, Mistry J	anon	Prosite	Family	This is a family of atypical serine kinases which are found in archaea, bacteria and eukaryotes.\	      Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome maintenance.  The structure of RIO1 has been determined [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.31	0.71	-4.95	28	1707	2012-10-02 22:05:25	2003-04-07 12:59:11	17	19	847	16	1056	4738	997	172.30	27	45.74	CHANGED	sVYpuhs.....tsup.....................phAlKla+sutssF+c.hccYlss-hRap..h.+tsh+pllchWAcKEa+NLpRltptG.l.VPcPlshpcplLVM-alG.tpGhsAPpL+-sp.......tcscplatcllp......hcthYpcspLVHuDLSEYNlLlpcs.clhlIDhuQuVphs.HPpAhpaLcRDlpNltpFFc++uss....hhshcpl	.............................................................................................lahs.s........pt.......................hshKla+.......h.......s.h............h.......t.......F+......p.......h.......cph.......h.......s....h..........p.......h.......+.....................h.p...p...hs.......h...h.h......c....h....h.s........p...+...E.hp...sL.t............p..........l.....t.....p...........s..................G.......l...............s......P...c.........P........l........t.........h..........p..........c......p........l........l......l...M......-...h....ls........................G..........h.....s.....h....s....p....L......p.-.s.p.......................tp.h....t...p........h...a...t..p.llp................hh...t...h.....h......t..ps.....s.......LlHu...D..L..S.E...a...N.lL..l...............p.............p............s.....p..............h.....h..lI...D..h...s.......Q..s...V..........ph.....s....p.......s.............p..............A..............t.........h........h..pR..Dlpslt..p.aFt+hh..........h..................................................................	1	337	599	872
+797	PF01000	RNA_pol_A_bac		RNA polymerase Rpb3/RpoA insert domain	Finn RD	anon	Pfam-B_172 (release 3.0)	Domain	Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal	21.30	21.30	21.40	21.70	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.56	0.71	-3.91	59	7300	2009-01-15 18:05:59	2003-04-07 12:59:11	21	25	6097	183	1610	4907	2300	120.20	33	38.59	CHANGED	VpI..su.......ltHchuhlshlpEDlhc....hlh.hKth...............psp-ps..hlpLpspGsup..................VhAuDlph............sssVcll....................ss-hhIspLscstc.lchchpsccGhGhs.Ac....................ao	.........................hph..............VhHEa..SolsGV..pE.D..V.hc....IlLNl.Ktls....h.......................psppcp......hlplshp.Gsu.................................VTAuDIp.h....................................................sucVEIl....................................................N..P-.hhIssL...s..c............s.s..p..lphclplp+GRGYlsAp..tppptt.....h...........................................................................................................................	0	566	1019	1357
+798	PF04997	RNA_pol_Rpb1_1		RNA polymerase Rpb1, domain 1	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 1, represents  the clamp domain, which a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [1,2]. 	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.06	0.70	-5.18	24	12239	2009-01-15 18:05:59	2003-04-07 12:59:11	7	127	9183	179	1981	10137	4485	254.70	33	31.57	CHANGED	h+clcplpFulhSP-pI+.phShsclpps-ohp.sp...pPcpsGLhD.+lGs.........hcpch.............hCpoCthphtc...C.GHaGHI-LspPVaHIGahctlhplLcplChhCuplhhsppt......hhhp.t.......thsphp+hphlsphstppshpcts...............................................................thtp.pshhtc.G.hslhthhc........tcphpcpht......hps.pshplhc+Isccchhlhuhsspts.+P-hhILoslPVPPPslRPuV.h-utp...hu-DDLThpltcIlppNppL++hppp.uAPptllpcphphLQ.plsshhDN..thsuhs.st.pssRPlKSlspRLKGKpGRhRsNL	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..phGaIcL.s...P.l..Hl.......h.ah..pt.l.p...ch....s..h.h..........s.h...........t...hp.........s.........-......p..............h..........h..h..h..ht...........................ss.h.p.p.h.ph......l.h....p......p.....h...h...p.....h...h...p.c...hs......................................................................................................................................................................p...............t....t......G...............t.l..h....t..h...hct......................t..pph....p...hp..................hp.s.tt..s...p....h....hp..+....h.........cc.............h.......h..........h.............u.......h...................t.........s..........h............s.........+..........P.........-.........W........M.l.........l.s.l.lPV.PPslR....P.........l..l..D....Gut......hu..p....sDL...s..hhtc......l....Ip.......t.......N....s...............p......l..............p..+...h........................p.........................s....u.........P.................t..............h................l............l..p..................p...........................cp.........h............L...Q..........t.Vss.h.hDN......s.h...t.................s.....s.............h.........................t......t.....+.sh.Kuht..ph.lcGKp.....G.........RhRtsL.....................................................................................................................................................................................................................................................................................................................................	2	707	1252	1678
+799	PF00623	RNA_pol_Rpb1_2		RNA polymerase Rpb1, domain 2	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 2, contains the active site. The invariant motif -NADFDGD- binds the active site magnesium ion [1,2].	23.40	23.40	24.50	23.60	22.90	23.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.15	0.71	-4.29	33	13383	2009-01-15 18:05:59	2003-04-07 12:59:11	15	145	9364	137	1887	9901	3260	133.80	57	17.84	CHANGED	GKRVDaSuRoVIss-PsLclcplGlPhphAhpLphPphlsphNhcclpphh.pt.p.a.th..h..p.pus+phlptt.........s.plh.................tlhR+lhcuDlVLhNRQPoLH+hSIhuHcs+llpt...+ohRLp.sVCssYNADFDGDEMNlHlPpo.pA+uEuhpLhhs	.............................................GKRVDYSGRSVIlV.GPp.LpLaQCG..LP+c.hAlELFps.Fllp.tL....t.pp...lAs...................................................................................s....l........t..s..........A.......K.....ph......lccp................cs..hVW............................................................-lLpEVh.p..sHPVLL.....NRAPTLHRLGIQA..........FpPh....LlEG......+AIpLH.P.LVC....p.uaNAD...F...........D........G.DQ........MA.V.H.V.PLShEAQuEARhLMh.s...............................................	0	671	1188	1598
+800	PF04983	RNA_pol_Rpb1_3		RNA polymerase Rpb1, domain 3	Bateman A	anon	Pfam-B_288 (release 4.2)	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking [1,2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.91	0.71	-4.50	112	9996	2009-01-15 18:05:59	2003-04-07 12:59:11	13	133	7655	137	1909	7790	3140	147.50	24	14.34	CHANGED	pIloPpsGcPlhussQDhlhGsYhlTtcc.........................sFhspp-shphhtts............................................................................................................pssIhhs.pt....................................haou+phhuhll.t..............pl.hpph..............................s.hhlppu.lhts.lsct.hu........tpshusllphlhcchG.ptssphlsplpplshtahtptG.holGlsDh	..................................................................................................................NllsPtsGcPlhsssQDhl...lG.hYhhThcp.........................................................................................hFhshpcsh.hh..h.................................................................................................................................................................................h..pst..l.hh....t..............................................................................................................hhhhc..p..hh...uhh.l.s..........................pl...th.........................................................................................................h.hlpps...h.................................s...........................pshupllphh.hp..c...........h....Ghp..ssthhsplppl....s.htahhh...tG.holGlsDh........................................................................................................................................................................	0	675	1204	1625
+801	PF05000	RNA_pol_Rpb1_4		RNA polymerase Rpb1, domain 4	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 4, represents the funnel domain.  The funnel contain the binding site for some elongation factors [1,2].	24.80	24.80	24.80	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.59	0.72	-4.31	106	8924	2009-01-15 18:05:59	2003-04-07 12:59:11	12	128	7522	137	1812	6872	2412	93.40	29	8.38	CHANGED	lppscc.scl...ph.upshccshc.....thhpph.hs..pc............tp.................NslhhMstoGu+GShhNlsQlsuhhG..ssps.p.........p.h.............php.h.ptPhspGFh	........................................................h....cchpcl.....sh.spstcpshc......shhspl...s.....p.pp..................t..t....t.t.....................................NslhhMus.SGA.+GS.............sh.....plpQlsuhhG.hu.........h.s.t.......................................h..........................................................	0	647	1141	1537
+802	PF04998	RNA_pol_Rpb1_5		RNA polymerase Rpb1, domain 5	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound [1,2].	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null --hand HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.68	0.70	-5.14	27	9187	2009-01-15 18:05:59	2003-04-07 12:59:11	12	161	6820	151	2086	7646	5482	395.80	25	36.28	CHANGED	GLsspEFFFHsMuGREGLlDTAlKTAcoGYlpR+LlKshEDlhlpYDsolRsustpllQhhYG-DulDshphcthshhhh.hhsh.hptphhhshtp.hhhttt.........................................................................................................................................hthh.csthtphplhp.hphsppthpphhshhpspappsllpsGEuVGhlAAQSIGEPuTQMT.LpTFHhAGsuupssT.GlPRl+Ellplspstppsshsshhhhshspcptphhthphttpphthtthhhtt.hhhs.s.tpshtpptt.hhhphhhh.pp.tpt.hh.......hh.......h.h......................................................................................................................................................h......t....t...p.hhtttttthhtpththpptppthshpthtthtphtth.hphhhhhtsspthhhthhhsptthsspshh.htstchllph.pGsslptlhp......hps...lpss+phoNp..lhphhchlGIEAuRpsllpElpplhttcGhtlshRHlsllsDhMThcGhlhul...oRtGlspp.pShh.h	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLsshEaFhpshGuRc.............G.L.s.DTAl+T.ApoG......YLpR..RLVcsh.p-lhlp.cs..s....s....p....p....p....s....h.........h.....h........h..h...G..t..-hhtsht.ch.thhhhp.hhts.ptthhh..tt.h..t................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.h.ttthpthhlpsshsppsp.hhshhshspshhptphlp...GEA....V.GhlAA...QSIGEPGTQhT.h+TFH.....h....u..Gs..u...s...t....s....................h.s....s..........p.......hp.p.......hp.h......p.................h...t..............h..t....................................................p....t....t..t......h....h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...h.h.....h......t.............t.....................t.......h.........................t.................h....h.....ht....p.....l.p.pV..ap.........pG..h..t....s+php.h..lp..ph..h..p.p..ht....l...t.s.t..p.o............h.h........h.p.....h...................h............s......ch...................h......t...................ht..hp.....lhu..l...T+.tu.ltpp..ohh..s.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	752	1323	1780
+803	PF04992	RNA_pol_Rpb1_6		RNA polymerase Rpb1, domain 6	Finn RD	anon	Pfam-B_288 (release 4.2)	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module [1,2].  This family appears to be specific to the largest subunit of RNA polymerase II.	21.10	21.10	21.90	22.40	20.60	19.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.11	0.71	-4.55	153	1575	2009-01-15 18:05:59	2003-04-07 12:59:11	9	78	1215	90	258	1468	151	157.90	39	18.62	CHANGED	hDGshlE.pQpl-slphSsp...pF-............+ca+lDl......s.spshh...........tshlptsh..p-l.tussc...h........QphL-cEacQLppD.....................RchLR......plhssu-.sphs..LPlNlpRlI.NApphF+...I....cppps.SDLpPhcllpsVcpLhc.+.LllVp..............................G....cD............................tLS.........pEAQpNATLLFphhLRSpLAsKRVlp.Ea+LsppAF-WllGEIEsRFppu	............................hDuhhlE..QplshlphSsp...tF-...................+ca+hDh.............s.spphh.......................pch..hp.s......p-l..hsshp..s......................p.L-pEa-pLhpD.....................RchLR.........p.l..h..sp....u-...pph................LPhNltRhl.sApphFp....l.......ptp.t...osLp.Ph.........c.....Vl.s...VppL...c+..hhlVt.................................G.....pD.............................lS.........hpApp.NATlLFphhLRSpLs.Kcl.sp.Ea+Lsp.AF-allGElEsRFtpu.................................................................	0	98	149	223
+804	PF05001	RNA_pol_Rpb1_R		RNA polymerase Rpb1 C-terminal repeat 	Finn RD	anon	Manual 	Repeat	The repetitive C-terminal domain (CTD) of Rpb1 (RNA polymerase Pol II) plays a critical role in the regulation of gene expression. The activity of the CTD is dependent on its state of phosphorylation [1].	20.30	6.20	20.50	6.20	20.20	6.10	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.46	0.74	-6.69	0.74	-3.36	99	4609	2009-01-15 18:05:59	2003-04-07 12:59:11	8	80	222	10	2717	4635	45	14.20	79	15.78	CHANGED	SP..s.SP.....s..Y..SP...o.SPsa	............SP..T.SP.......u......Y..SP.....T..SPuY..............	0	913	1434	2266
+805	PF04565	RNA_pol_Rpb2_3		RNA polymerase Rpb2, domain 3	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site [1].	21.00	10.30	21.10	10.40	20.90	10.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-8.99	0.72	-4.22	31	16867	2009-09-13 23:49:08	2003-04-07 12:59:11	11	131	12522	133	1834	13597	2855	63.90	55	9.45	CHANGED	Qhh-phN.loploHhR+lsh....Guls+cptshcsRclHsopaGhlCPl-TPE.GtssGLlssLuhhscls	.........................Qhhsph.s.lSp.loHhR..Rls............uuL..s.R-p..t.thc....sRclHsTHa....GhlCPhETPE.G..shGL.lpsLuhhupls....................	0	652	1156	1555
+806	PF04567	RNA_pol_Rpb2_5		RNA polymerase Rpb2, domain 5	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain [1].	20.40	18.00	20.40	19.00	20.30	17.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.28	0.72	-3.99	64	7512	2009-01-15 18:05:59	2003-04-07 12:59:11	12	60	5291	96	702	6482	353	64.00	49	13.61	CHANGED	apsLlppG..llEYlDsEEEEsshIuhs..th.......................................stp.sppaTHhEIaP	.............WcsLlcsG.....llEYlDAEEEETsMIsMTPEDL-...R..ptsh...............................................................ttt..p.hht.hsss..sHhaT..HCEIHP...................................................................	0	239	399	587
+807	PF00562	RNA_pol_Rpb2_6		RNA polymerase Rpb2, domain 6	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain [1].  The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex.  This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion[1].  This domain is also involved in binding to Rpb1 and Rpb3 [1].  Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).	23.40	23.40	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.31	0.70	-5.72	117	16703	2012-10-01 19:23:01	2003-04-07 12:59:11	23	139	12411	138	1943	12966	6003	307.10	35	46.19	CHANGED	slhAphhshspaspusRh.......................hhps...scps.t...................................................................hhshs.phpRssps.s...phsQ+P..lVpst.tlctsp..............hs-lshGpNslVAhhsasG.YNhEDulllscphlccshasSlahcp.....hps..........ccpc..hG..-chhpphsss...........scpshppL..Dcs....Gll.............................pl...................Gst......VpsGDlLlGKh.....s............hpthhsppspp.h+DsSlphtts..pp.GhV.cVtl.............................................................................................................................................................................................................................................p.sss.s.....hphl+VhltppRp.plGDKhuuRHGpKGlluhlhPpEDMPahp.cGh..ssDlllNPhGlPSRMsl...................GQllEshhGhAush...........................................................................pG.hhhssssFs...........................................................................................p..................ppl...............................tchLp.....................c.....t.....................................................................................Gpp..............hlasGpTGc.h.......cs.lhlGhhYh.KLpHhVs..DKhHAR.upGPhs..hl.....TpQPltG+up	.............................................................................................................................................................................................................................................s.hhuph.shl...sp......us+h.......hhts.....ttt.t.....................................................................................................................h.h..h.a.p.RoNpss.....shsQ+P..hVp..hs........l...ctsp............hs..........t......hs.ELshG.....pNhlVAhhsa.....pG..YN.EDul.........lhspp.l.cshapShahcp...h.............................p.pp...........t....p.c...hh.t.c..p...............................ttthhppL.D.c.p......Glh...................................................Gs.......l......t.t..c..lllu+h.................................................t.h...t..p......h+-...sh...h.....s.......t..Ghl....tl.h.......................................................................................................................................................................................................................................................................................................t....s.......hl+lh..hh.p+h.p...GDKhuuRHGp.K...Ghlu.........hhh.....pDMP..a..........pG.........h....s..........s..DlhlNPhulPSRMsl...................uplhEh.hhuh..sut...........................................................................................................................................................................s......h..t..sss.Fst................................................................hp.........................................t.l.t.l.....................................................................................................................................................................u...hh.s..Gh.oGp...h............h.....................................................................................................................................................................................................................	0	704	1234	1655
+808	PF04560	RNA_pol_Rpb2_7		RNA polymerase Rpb2, domain 7	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  Rpb2 is the second largest subunit of the RNA polymerase.  This domain comprised of the structural domains anchor and clamp [1]. The clamp region (C-terminal) contains a zinc-binding motif [1]. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription [1].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.99	0.72	-3.72	134	7219	2009-01-15 18:05:59	2003-04-07 12:59:11	15	94	6073	138	1845	5823	2697	79.50	52	6.84	CHANGED	GGQRFGEMEVWALEAaGAAasLpEhLTlKSD....DlsGRsphhps...................IscGcsh.css.lPESF+VLl+ELpSLulslclhtp	........GGQRFG.EME.......VWALEAYGAAa.sLQEhLT.l.K.SD......D.V....sGR..s+hYcs.........................................................................Ilc..G...c...s....h.....cs...G..hPESF+..VLl+ELpSLulslcl..p...................................................................................................	0	651	1163	1560
+809	PF03874	RNA_pol_Rpb4		RNA polymerase Rpb4	Finn RD, Bateman A	anon	Finn RD & COG1460	Family	This family includes the Rpb4 protein.  This family also includes C17 (aka CGRP-RCP) is an essential subunit of RNA polymerase III. C17 forms a subcomplex with C25 [5] which is likely to be the counterpart of subcomplex Rpb4/7 in Pol II [4].	21.60	21.60	21.90	22.40	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.49	0.71	-4.09	88	790	2012-10-03 03:05:55	2003-04-07 12:59:11	11	11	467	61	545	755	50	113.00	23	70.54	CHANGED	hLo.sEshplLp.phpppppt...................................................................phsplhp..cslc.Ylp..p......................huchppt-s.........................spplhptLp......php........L.pchEthplsslhPpshsElpsllsphcp....................................ch..........s-...-plpplLchlpchh	..............................................................................................................L...Esh.lLp.phpppppt................................................................................................ttptphs.phhh..colp.Ylp.p......................hu+hp.spEs....................................................................lppl.h.phLp..............php..............L.p..chEh..h......pl.......s...NlpP..po..spEhpsl...ls.ph.ct....................................+..h..........s.-.....-plpplLc.lpp..h......................................	0	176	309	446
+810	PF01351	RNase_HII		Ribonuclease HII	Bateman A	anon	Bateman A	Family	\N	20.60	20.60	21.20	21.00	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.10	0.71	-4.67	14	6064	2012-10-03 01:22:09	2003-04-07 12:59:11	13	19	4789	32	1433	4292	2775	182.20	35	75.83	CHANGED	hGlDEsGRGslhGPlVsAushls.cp.....h.thGlcDSKKLocp+RptLtchIp...................pthhuhtlsh..hpssphsthsltpsshhshhc.tlpph.slpsc..tlhlDu.ps.....Pt.hththps.lht.............uDuths.luAASllAKVpRD.hhh-hhpchsth.shspssGYsoc.+tptlhchssss.......htRhoFtss	......................................................sGlDEsGRGsLsGPVVs..AAV.....l......L........s....s..p..........................................h............G...l....s..DSK+.L..o.c.p.+.R.p..p.LhptIp....................................................................pp....sl...sh..sluh......spsp.c.I.....D..p.......l.....s..I..hp...A.s....h....hA...M....t..........c....A....l.......t.......t.......L........s......h......p......P..c.....................hl..L..l...Du.ph...........................st...h.....s...h......s...t...p...s...l....lc..................................................GDupsh.sIAAASIlAKVsRD..th.......M...h...............c.................h............s..........p.....p...............a..........P............t..........Y...............s...............a.............s...........p......ptGY.s.T.ptHh.pslt..chGsss..........h.HRpSFts.................................................................................................................................................	0	496	923	1217
+811	PF01138	RNase_PH		3' exoribonuclease family, domain 1	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family includes 3'-5' exoribonucleases.  Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction.  The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA.  Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	21.00	21.00	21.10	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.70	0.71	-3.84	192	13598	2012-10-03 01:04:38	2003-04-07 12:59:11	16	86	4722	247	4120	10174	6384	132.80	29	40.48	CHANGED	phRslplch..G...hhppAs...............GSshlphG..................s..TpVlsslpsst...t..............................tt..s..............lslphpht...shussph.......................pp..st....ssccph..........hup....l.......l............ccslcssh..........h...........phh.......hplplshpllss................DG............................................shhssul....suushALhsuslP	........................................................................................hRslslcs..G......hh.t.p..u.c.................GSs.l.h...phG......................-....Tp..l.L.s..s.so..hsp...ts.........................................................................hh.....-.hs........................t...ltscYph.........sausGch...................................................tpt...Gp......................suc+ph..................thuR.......L......l......................................................cR.u.....l..+..slhs....................p..................................................................tth.....hsl.p.ls....s...pl.lp..u.....sG....................................................us.p..h..A.u.l....sG.uolALhsuslP.............................................................................................................................	0	1408	2573	3461
+812	PF03725	RNase_PH_C		3' exoribonuclease family, domain 2	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family includes 3'-5' exoribonucleases.  Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction.  The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA.  Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.01	0.72	-4.04	107	12290	2009-01-15 18:05:59	2003-04-07 12:59:11	10	60	4627	243	3309	8916	5491	69.10	29	20.56	CHANGED	shssuloluhl..s............sp.......hllDPsh.pE-.................htpu...slslsh........ssst..........ph.slhpt........ss....st....lspcplhcslchutps	.................................................sslAuluhGl.l...s.....................................sp.............hlh..Dhph...pE-..............................hu.ts..........Dh-hhV.........AGop................cs.h...sshtt................................stth.......tloc-.hhpALthA+p..................................................	0	1115	2087	2755
+813	PF02755	RPEL		RPEL repeat	Ponting CP	anon	Ponting CP	Family	The RPEL repeat is named after four conserved amino acids it contains. The function of the RPEL repeat is unknown however it might be a DNA binding repeat based on the observation that Swiss:Q9VZY2 contains a Pfam:PF02037 domain that is also implicated in DNA binding.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.67	0.72	-6.75	0.72	-4.50	54	1765	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	175	8	892	1495	0	25.80	41	10.30	CHANGED	cpLp++lspRPsh-ELlc+sILppps	........pLp+KLupRPshcELhc+sIL.tp.....	0	145	243	514
+814	PF04059	RRM_2	rrm_2; 	RNA recognition motif 2	Wood V, Finn RD	anon	Pfam-B_4981 (release 7.3);	Family	\N	21.00	21.00	21.00	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.47	0.72	-3.98	4	387	2012-10-02 20:46:34	2003-04-07 12:59:11	7	16	140	0	313	408	9	92.10	44	16.81	CHANGED	RTTLMIKNIPNKYTppMLlutIDE+sKGTYDFLYLPIDFKNKCNVGYAFINhlpPppIlsFhcAFNGKpW-KFNSEKVAoLuYAcIQGKsALIu+FQ	...........................RTTlMl+N..IPNKaop.p.hLhshl..D.c.........p.....p..............p............G........p.......YDF..h.YLP.ID........F............p..........N.c......C.....NlGYA..FINhhsstthh............tFhp......sFp..........sp+W........p.t..F.s.........S.......c..........K..lsplsYA+lQGp.psLlt+Fp................................	1	154	233	283
+815	PF01137	RTC	RCT; 	RNA 3'-terminal phosphate cyclase	Finn RD, Bateman A	anon	Prosite	Domain	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate [1]. The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids [1]. 	20.60	20.60	20.70	20.80	19.90	20.40	hmmbuild  -o /dev/null --hand HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.31	0.70	-5.57	29	1194	2012-10-02 15:27:11	2003-04-07 12:59:11	16	17	881	19	569	985	32	309.70	31	89.51	CHANGED	lDGShtEGGGQlLRouluLSsloGcPl+I.hsIRAsRsp.PGLppQHLsulcslpclssAplpGhplGSppLhFpP...........uplcGG.shphDl......GTAGSlsLlLQslLPhhhFucpssclplpGGTcsthuPslDal+pVhLslLc+hGhpsc...lcll+RGaYPcGGGcVhhplp........Psp.hs.lphhchupltplpGhuhssplssphupcptcssttthsphh.tshhhttt........................ssusshhhshpppsshhuusulGc+GhsAEtVGccAAppLlcplpsuusVDcahuDpllhahALuss...phpsuclos..HhhTsltllcpF.hshca.clct	.......................................................................pGs.tcGGGQllRpuLsLShloGpPhpI.ppIR........u..s..............R...s...............p...P..............GL.............h..............ppHlosl+hhscl.........s.s.....u..s..l..........u.....s.............phuup.plhFpP....................................Gt.l.p..G......G....php.....ash................so.A..u.ShsLlLpsl.LshhhF..........u................c...................s.......s.................p.....lpl..p.G......G.T....s..s..s.....uP....s.....hDalcpl.hhP.l....L....t.+.....h...G.l...p.tp.................hp.l...h++...G....a............h...P.....t....G....G....G.Vthpls....s.st.t.h.p.slpLh-pGplhphpG.shhssls.phspRthtshts.hthh..shh.hspp................................................................................................................................................................................................tssssss.hthpspshttth.shGpptsssEslutpsspplhc.ltpsusVsc.ahtDplll.MAL........u....s........s..............................u........chp...l........u.......p.........o..........HhhosltllcpF.hsspFt...h........................................................................................................................................................................................................	0	191	322	470
+816	PF05189	RTC_insert		RNA 3'-terminal phosphate cyclase (RTC), insert domain	Finn RD	anon	manual 	Domain	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate [1]. The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids [1]. 	20.60	20.60	20.80	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.14	0.72	-4.01	99	1028	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	852	19	465	818	15	100.70	29	28.85	CHANGED	h-pGplp..c....lpGlu..asspl.ssplApR.hcuAcp.hL.....th.h.-lplps..................tpsuh.usGsGlsLhAcspp..shhuusul..................GpcGhsAEcVGccAAppLlcpl.psu	.......................h.-pGplhp..hRG.s............h..s..s.s.V..shpl..AcR.lssstuhh............sh.l.t-hpIps............................hspsp..u..PGsuloLhsE.....ops............h.hhthpsl...................................................Gcctss..AEsVutpsucplhc.ltp.............................	0	153	268	382
+817	PF00301	Rubredoxin	rubredoxin; 	Rubredoxin	Finn RD	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.78	0.72	-4.09	43	2943	2012-10-03 19:45:42	2003-04-07 12:59:11	15	40	1967	86	844	2104	307	46.10	48	23.38	CHANGED	+ahCpl..CGYlYDsspGDstpslsPGT.Fc-LP--WsCP.C..Gss.KcpF	........pa.Cpl..C.G.alYD..s..stG-P..........p...p......s..l..s.PG.T.......a...p....-l.P.-.c.WhCP.C..usu.KssF........	0	288	568	732
+818	PF02759	RUN		RUN domain	Bateman A	anon	[1]	Family	This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases [1].	20.70	20.70	21.00	21.20	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.78	0.71	-4.40	50	1686	2009-01-15 18:05:59	2003-04-07 12:59:11	14	59	103	6	970	1562	5	138.00	21	18.38	CHANGED	sLssslEtlLpHGL+t...........................................................................................................p..thhhtpppshashhpph.................tph.hsssppl...hpplp.plpplpss..........................................................pu+......................t+AWl+hAL.c+hLspalphLhpspp...hl.............s........paYpstAllhsstts......hlhslLsuLss.lsFslshps	..........................................................................................................................................................................................hssslEthltHGL+t...................................................................................................................................................................................................p....hhhh..t.p.pp..shas..hh.pth.................................................tph...hsp.tp.ph............hpp.l......p....sl...pp..l..p..ss....................................................................................................................................................................................hu+.......................................t+Aalp..hu...L...........c..+h....Lspa.l....ph.Lhp..spt.....hh..................................p.........c.aY.c.t.t.Ah....l..h...sppts..........lhshL.hsL.ss.lpashsh..............................................................................................................................................................	1	257	332	591
+819	PF00853	Runt		Runt domain	Bateman A	anon	[1]	Domain	\N	20.50	20.50	21.10	26.40	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.74	0.71	-4.71	6	488	2012-10-03 00:25:27	2003-04-07 12:59:11	14	7	118	24	206	469	0	119.90	74	31.17	CHANGED	ERols-hlsEaPGELV+TuSPsFlCSsLPuHWRSNKTLPlAFKVlALGEVsDGThVTI+AGNDENaCuELRNsTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIoIuTsPPQlATYs+AIKVTVDGPREPRp+ppp	............................Rshs-hlu-Hsu.ELVRTsSPsFLCSlLPoHWRsNKTLPl.AF.K.........VVAL..G..-......VPDGT...l............VTVhAGNDENYsAELRNAoAlMKNQVARFNDLRFVG....RSGR.....GK.S.FTL.TITVh.TsPP.Q.VATYpRAIKVTVDGPREPRp+pp.........................	0	47	63	141
+820	PF00665	rve		Integrase core domain	Bateman A	anon	Pfam-B_10 (release 2.1)	Domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.26	0.71	-4.00	230	47519	2012-10-03 01:22:09	2003-04-07 12:59:11	21	846	4253	244	8847	47451	3435	111.40	27	21.34	CHANGED	psppshphhphDhs...hhp..s.t................................talhshlDshS+hhhshhhppc........ssptshphhpthhtthtsh...............hhlpoDpGspassp...............phpphhpphG..lphphspstsPpssuhsEphpppl+pph	...........................................................................................s..tts.thap.hDhs......hhp.......t......................................th...lh.sh.l.....c...s..h.S...t.h...l....u.......s..l.s.sc...................................sp.p...s..s..h..t.h...L.......c.............l...t...s.p.h.s...............................................sphl.+oD.s.G..s.p.Fsot.........................................th.p.t.h.....t...h.h..t.G......l...p..p......p.h....u........h.s.......h.......s.......P.p...s......p...G.h...sEsh..sppLKp..h...............................................................	0	3423	5434	6849
+821	PF00077	RVP	rvp; 	Retroviral aspartyl protease	Eddy SR	anon	Eddy SR	Domain	Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam:PF00026).	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.29	0.72	-4.09	50	124336	2012-10-02 15:32:34	2003-04-07 12:59:11	15	164	892	1164	420	112085	121	94.30	86	28.21	CHANGED	sh.pcPhlplplsGp.............hpsLLDTGADcollpptphshp......hpsphltGlGGth.pscphpphhlplttcphps.....shllhP..sPls......llGRslLsphsspLs	...............................................T.LWQRP.LVT.IKIGGQ...............LK.E.ALLDTGA.DD.TV.L.....E....E...h......N...L....P....G....+.....................W.K...P....K........M.I....G....G....I.......G...GFI.......K..V....R....Q.......Y.......D....QI........I.E.....I...CG.HKAIG.............TVLV.G..P...TPVN..............I.IGR.NLLTQIGCTLN.....................................................................	0	190	263	349
+822	PF00078	RVT_1	rvt; RVT; 	Reverse transcriptase (RNA-dependent DNA polymerase)	Eddy SR	anon	Published_alignment and HMM_iterative_training	Family	A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.44	0.70	-4.98	152	172360	2012-10-02 12:54:00	2003-04-07 12:59:11	22	1060	4989	405	8257	157991	1195	171.90	64	42.06	CHANGED	l.Kps...........uphR................ph+hlschhtp.............................hp.sphuh.shtsh.................htps.phhhplDlpsuFpplshs.hhp.hhpshshst..........................................................ttphphpslPQGhhhSPhlaphhhpplhp.lpp.........................................................................thhhhtYsDDlllhsps.tpp..........hpphhptltphlpp...hGlpls.cKsphh.......................................tpphcaLGhpl	........................................................................................................................................................................................IKKKD...........STKWRK..L.........................V.D..F.R.E..L.N..K.R.T.Q.D.........................................................................F...W.E...V...Q..L.G..I..PHP.A.GL....................................................................K.KK....KSV...T..V...L.D......V..G..D..A...Y........F.....S........V.....P.....L....D...c.....-....F.........R....K..Y....T...A...........F....T........I...P.........S......h....................................................................................................................................................................................................................................................N....NE.....T....PG....I.......R...YQY.N.....V....LP...Q..G...............W..K...G...S...P...A..I.F....Q....u..S....M.T..K.....I....L..E....P..FR+pN...............................................................................................................................................................................................................................P-I...V..I..Y...Q.YM...DD..L....Y.....V...G....S..DL...EIGQ...................HR.s.K....I..E....E..L.R.p......HL....L+.....W......G....F..o.....T.....P...D.....K....K..HQKE..................................................PPFlWMGYEL..............................................................................................................................................	0	3604	5373	6662
+823	PF03501	S10_plectin		Plectin/S10 domain	Barker W, Wu C, Bateman A	anon	Pfam-B_2138 (release 7.0)	Domain	This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.	22.20	22.20	22.20	23.00	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.25	0.72	-4.13	39	605	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	384	4	306	562	4	93.60	56	26.87	CHANGED	lPKpsRptIYcaLFcEGVlVAKKDhphs.pHs-........l...slsNLpVl+shpSLcSRGaV+EpFuWpaaYahLTsEGIcYLRcaLaLPs-.lVPuTh++pspst	...........hPKpsRhtIYch.LF.+.E.GVhVAKKDhphs...KHP-..........l...slsNLpVlKAhQSL+S+G.Y.VKEpFuWpHaYWaLTNEGI-YLRpYLHLPsE.IVPATL++pt+...............	0	106	165	242
+824	PF01479	S4		S4 domain	Bateman A	anon	Medline:99193178	Domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.81	0.72	-4.53	155	36010	2012-10-01 23:15:27	2003-04-07 12:59:11	20	39	10093	225	6709	24712	7637	47.10	28	18.58	CHANGED	hRLDphl..hchshspopppAcplIppGcVtVNGchls.suhtlp..ss-hl	..................RLDphl.......hch...u..h..s..s....oRspAc.pllpp..G..c.l.t..V..NG....c....h.lp..suhplp..stDhl......................	0	2224	4271	5635
+825	PF04382	SAB		SAB domain	Bateman A	anon	Bateman A	Domain	This presumed domain is found in proteins containing FERM domains Pfam:PF00373.  This domain is found to bind to both spectrin and actin, hence the name SAB (Spectrin and Actin Binding) domain.	20.90	20.90	20.90	20.90	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.27	0.72	-4.27	6	436	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	42	0	117	282	0	48.50	54	6.12	CHANGED	Khc-LDKoQD-llKHQASISELKRoFhEo..sspsRssEWE..KRLST.SPhR	..................hc-LDKsQ--lhKHQASISELKRsFhEo..sspsRssEWE...KRLoT.SPhp.......	0	4	12	42
+826	PF03399	SAC3_GANP		SAC3/GANP/Nin1/mts3/eIF-3 p25 family	Mifsud W, Moxon SJ, Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_2845 (release 6.6) & Pfam-B_4388 (release 7.5)	Family	This large family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins.  The family includes the yeast nuclear export factor Sac3 Swiss:P46674, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localisation of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.  The 26S protease (or 26S proteasome) is responsible for degrading ubiquitin conjugates. It consists of 19S regulatory complexes associated with the ends of 20S proteasomes. The 19S regulatory complex is composed of about 20 different polypeptides and confers ATP-dependence and substrate specificity to the 26S enzyme.  The conserved region occurs at the C-terminal of the Nin1-like regulatory subunit [4,5,6].  This family includes several eukaryotic translation initiation factor 3 subunit 11 (eIF-3 p25) proteins. Eukaryotic initiation factor 3 (eIF3) is a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits [7].	26.10	26.10	26.20	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.39	0.71	-4.76	105	1100	2012-10-04 14:01:11	2003-04-07 12:59:11	11	24	325	2	789	1485	13	199.20	22	28.32	CHANGED	ppssPppl+shcllhhphphlhtph....................salhsph+uh+pD..lpl...........slplhEhtshhtl.p..............tc...........ltpasp.sht...pLh.hYtp.............................................p.pps-hhuhhLL.hhL.ps.....................s-hppplph.L.............................................tt.h.psthlphslplpphltpus.........................Yp+Faplh......p.................pss.hhstlhc.h.ahsplRhpshpsls+uYpp...........lslphlpphLsh	..............................................................................................................spplR.....s..hL.tshphlht.h..............................t..a.tal.h-ph+ulRpDlshQt...h.s........slplhEtts+htl.p...................t-....................................hpphs.p...s.p.........pL..pt.hYpp..h......................................................................psppsEFtuY...h...lL.h.h.l....p.s.......................s-ht.p..p.ltt.l..............................................stp..hpps..........tlp....h....Alp......lppu.ht..pus.............................at..+aaclh...........p..........................................................................pss.....h....hshlhc..h...ahsph...R..tpulpshp.+uYp.................lslp.ltphLh.............................................................................	0	272	441	657
+827	PF03435	Saccharop_dh		Saccharopine dehydrogenase 	Finn RD	anon	Pfam-B_4166 (release 6.6) & Pfam-B_6325 (Release 7.5)	Family	This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase.  The saccharopine dehydrogenase can also function as a saccharopine reductase.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.07	0.70	-5.49	82	3742	2012-10-10 17:06:42	2003-04-07 12:59:11	13	32	2288	17	1319	4625	2619	321.10	19	76.28	CHANGED	llllGs.GslGpsshthltcphch........plslsspstpphpphhtt.........tshphpshslsssshps.Lssh.lpps...chllslussh..tsh.slhchChcpGstYlD....Tuh.....................hppthhphcpptt.....tuGsTslsssGhsPGlsshhstpulpclt.............................sphtphhulc.hasutt............s.tassoWSscGhlpE.hps........t...sElshtspppph...shhhtsGsshhhah.pcsushspshshhst.....shhhs...slphssahshhp..htshshhc.ssh.hh..................................................................hss.csltulhc.hssht.phpsh.hplh.hhc....Ghtc.Ghhhhtphpps..hspths.hppsppthshssusshtlsutllssshhs....ptGllps-ph.hp.sh...hhshlt...Gl.hs	..................................................................llllGu..G.hlu.p..h.s.s...p.h.....lsp.psph....................cl.s.l.A.....u..R...s.....t...p.+.h..ptl.ht.................................tth.p.h.p...s...h.t..l.....D....s....s....s.....s.....p....s....l...t.....th...lppt...........clV...l...s..ss......s.....Pa.............hsh...slh.cA..C..l..p..s.G.s....c.YlD.........ssh............................................................................h.ph.h..t..h....c..cp.hc......p.uGh.s..hl.us.G....h..D..P........G.hs...sh...hs.t...hhhp.....phh................................................................t..........l..t.....h.......s...uth........................ht.h.sa..s..s.t....h....h.t.........................h.......t....t....t..........t.h..........h..t............h.......................h...........h.h.........p.t....h...........................h..h...........h.........t.h.t.hht...........hht.................................................................................................................................phh..thh............................t............h..h.....h.......................h......s.................................................h.h.s.s....h....hh.......................................th.................................t.........................................................................................................................................................................................................................................................	0	431	806	1113
+828	PF00536	SAM_1	SAM_1;	SAM domain (Sterile alpha motif)	Bateman A	anon	[1],[2]	Domain	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.98	0.72	-3.80	65	6213	2012-10-02 20:42:54	2003-04-07 12:59:11	25	406	310	71	3366	7526	101	63.10	23	9.07	CHANGED	shhshpsVs-WLcu...l.th....spYtcpF.psshhshctlhplot-D..Lhp.lGlshhGHp++Ihpulptl+	.........................h...t.tpVspW.Lp.s...........l...sh.........sp.Yt..p.tF..p........p.....p......h......h...s.......s..c......t.....l..h.....p...l.o..p..p-.................Lp...p..lu.....l.p.t.....Gcpt+lhtulpth.............................	1	782	1136	2102
+829	PF02198	SAM_PNT		Sterile alpha motif (SAM)/Pointed domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.87	0.72	-4.22	15	1002	2012-10-02 20:42:54	2003-04-07 12:59:11	11	15	115	23	513	1149	0	82.10	32	19.96	CHANGED	hsuappppp+ltlst.....cPphWocscVhpWLpWuhcE..FsLsslshspF.pMsG+pLCsLs+E-FhptsP...hsGDlLapHLphLpcps	.....................................phtppphhlst......-P....ph....WoppcVtpWL.p.Ws.hcE....as..L.t..s.l.s..h..p..p..F...shsGctLCtho+--Fhph.s..P.......hsG..-..l..L..appLphlppt.s............................	0	109	148	306
+830	PF01342	SAND		SAND domain	Christensen J, Bateman A	anon	[1]	Family	The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerisation [2]. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri.  This region of RegA is known as the VARL domain [3].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.68	0.72	-4.27	27	491	2009-09-11 01:11:04	2003-04-07 12:59:11	16	30	96	4	249	486	2	78.20	33	13.91	CHANGED	scs.sh....sstlPVsCGpspGhLhhc+h.ptGhpt+CI............................phc...spahTPpEFphhu.G+upuKcWKpuIRh......sGhsL+pLh-cthLs	.........................t....sh...p..hPlsCGps.puhLhhp+h..ps..GhpsKCI............................php......spahoPpEFEt.hu.G+.ussKsWKpuIRh.....................sGhsL..p.plhcps.L.....................	0	51	98	148
+831	PF02037	SAP		SAP domain	Bateman A	anon	[1]	Family	The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.04	0.72	-7.33	0.72	-4.37	182	2887	2012-10-03 03:04:30	2003-04-07 12:59:11	22	173	629	14	1622	2724	591	34.30	34	5.81	CHANGED	hsphpVs-L+phLcppuLsssGp..KspLlpRLpphh	...........pphpVs-L+ptLcp+uL.s..ss..Gp..KspLlcRLpph.............	0	558	853	1248
+832	PF05184	SapB_1		Saposin-like type B, region 1	Finn RD	anon	Manual	Domain	\N	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.81	0.72	-4.05	161	1396	2009-01-15 18:05:59	2003-04-07 12:59:11	10	105	174	31	654	1402	4	38.80	27	19.67	CHANGED	sshCshCphhlphlpphl.p.sspopppIhphlcp.hC.shlP	..s.shCphCchlVshlpphL.c.sspTcpcIhphlcc.hC.shLP.....	0	247	355	514
+833	PF03489	SapB_2	Surfactant_B;	Saposin-like type B, region 2	Finn RD	anon	Manual	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.44	0.72	-3.89	103	1536	2009-01-15 18:05:59	2003-04-07 12:59:11	12	112	171	39	716	1502	4	34.80	28	17.26	CHANGED	sppCpplVppYtshllphlhpphs..PpplCp.tlslC	..........ppCcphVspYtshllphlhpp.....hs...PpplCs.tlslC......	0	242	367	546
+834	PF04499	SAPS		SIT4 phosphatase-associated protein	Mifsud W	anon	Pfam-B_2011 (release 7.5)	Family	This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.	24.90	24.90	24.90	24.90	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	475	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.59	0.70	-5.85	51	896	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	267	0	509	895	0	267.70	20	48.43	CHANGED	.ppLlspKspphlsF.l+ppcslVcphLpHI-ssslMDhLL+lIS...s-+....s-sspGll-hLpp.....QcLIs+LlshL...........................................s.schsts.hQosAuDhLKAlIolSu.Nss.p...pssIGP.................NpLoRpLsStphlcpLl.shML..............................................................................................................ps.usuLssuVuIlIElI......RKN............NSDYD...................................hshtspsP.os+D...............................................PlYLGp........lL+hFup+lscFhpLlhps..................ptt.lposhGs.hcPLGFcRFKlsELlAELLHCSNMsLhNp.t..thht.RD..R.t...t...ht...tp........t.t....p.......................t.........................................................................................................................................t........t.t..............t...t............................................................................................................................pPs.................lGDhlKlpLh-spllssILchFF+aPWNNFLHNVVaDllQQlhNGshc....................................huaNphLshcLF..................................cpsplsptIlcutcpspch.ppp..............thRhGYMGHLTLIAEEVVKFsphhss..phlo....hlhc..tlpspcWptalppsLs-.TRc.p.ss	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...............................................................................................................................................................................	0	148	248	376
+835	PF04000	Sas10_Utp3		Sas10/Utp3/C1D family	Bateman A, Wood V	anon	Pfam-B_6555 (release 7.3)	Family	This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex [2][4]. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs [3], and Sas10 which has been identified as a regulator of chromatin silencing [1]. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein [6].	20.50	20.50	20.60	20.60	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.78	0.72	-3.79	122	865	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	313	0	604	854	4	85.50	20	23.39	CHANGED	hlpslspslsplpspl..ptlhpth..................httths.................lhphKhphhhuYhtslsha........hhL+hp.shsspp............................HslhpcLhcl+phhc+	..........................................................................................lpphppplsplpstl...pslhpts...............................ttthss.......................h.hcsKhpllluYhhslsaa..........hhL+sp..uhssps............................HPlh.p.cLhclRphhc+...........................................	1	186	316	487
+836	PF01547	SBP_bac_1	SBP_bacterial_1; 	Bacterial extracellular solute-binding protein	Bateman A, Griffiths-Jones SR	anon	Pfam-B_269 (release 4.0)	Family	This family also includes the bacterial extracellular solute-binding protein family POTD/POTF.	20.50	15.00	20.50	15.00	20.40	14.90	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.87	0.70	-4.70	129	9759	2012-10-03 15:33:52	2003-04-07 12:59:11	20	37	2534	267	2818	28939	7759	292.70	15	65.96	CHANGED	ssshpp...shpthh.pp....a....pc..pss..lcVp..hp.s...sssshtp.....h.hthtsus...ss.Dlhhs........h.....hhpt..shhtslsshhtst.hh.h...........hh...h.............................shha.........ppphht............................sWs.-hhphstphttpstsh........................hhh.h.tthhhhh..h....s............................................shthh.thh.......thtshtshstshstshshht...........pGpsshhhsh.ht..........h......................thhtsttpst.phshh.....................sshs.hslspsupp....tct....AppFl........pahhss........................pspt	..........................................................................................................................................................................................................................tttt..........htphh..pt.............F.........pc....p..s.s......lc.lp..........hp.hh..........s....s...s..htp..................cl..p.s.th..s.u.Gs....................sP...D.lhhh...........sssths.............phspp...........Gh.l..h..s...l...s...s....h...h..sp.........t.....t........................................................................h......t...h.hp.....pht.........................tpha..ul....P............h..........t....s......s....t...........s........l..a..Y................................s.+c.lhc.................................chG.lp.................................................Pp...Ta......-......-....h....h...p....s....s.....c.....p....l....p....p...ts.hss......................................hhh...t.t...t...h.....t.....t..t....h....h.....h...h.............h...h...t...s.hG.........s....t.h..h..s.t.pht.....................................................sh.sss.thhp..............shph....htp..h..h........................................t.........t.....h....h......s..............s....s.....t....s......h......s...h...s....p....s....h....s..h.ht.......................................sGc..s..u...h...h..h.......s..s...h.....h........................................................................................................................h.t...t..t..t.t..t..........t...t....p....h..s..h.....h..sh...P.t....h.t.sst.t...........................hss.s..h..s..l....s....p....s...o..c..p...............ct............Ah.c.al................pahhs.t..............................................................................................................................................................................................................	0	1094	1940	2361
+837	PF00497	SBP_bac_3		Bacterial extracellular solute-binding proteins, family 3	Finn RD	anon	Prosite	Domain	\N	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null --hand HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.47	0.70	-5.10	483	31454	2012-10-03 15:33:52	2003-04-07 12:59:11	15	351	4322	113	7607	27422	5780	223.60	19	63.80	CHANGED	lpl.usss.shs.Pasahct............sGphsGa-lD....lhpt....luc.ch.Gh....c.hchh......h...sasshl.s.uLpsG.c.h.Dh.lhuuhsh......Ts-R..p..c.p...........ls.F.op.P..Yhts.stsllsp..p.....s.....................................................................................................................ph...p...t.........-L...pG....................+..p.....lu.ltpG.os....tpth...htp.......h................thpl....................h.....h.sshsps.ht........s.LpsG...clDAhls-tsshthhhpppsttthhh......................ttshtspthuhshpcssspLhptlspultpl.ppsGphp.....c.l.hp...Ka.hst	....................................................................................................................................................................................................................................................lhlu.h.ps..s..h.s..P.a...p...h...hst.................ss..p...h..h...G.h..-.lD................ls....p.t........l....sc....ph...sh.....................c..hp...hh....................h..sa.s....s...hl.....s....s.L.....p.....s........s.....c........h......D...h....l.....h......u.....s......h....o....h................T....s....c...R.......p...c...p....................................hs....F....os......s......Y....h......p......s......s.....h.......t......l.l.spp...s....................................................................................................................................................................................................................................................................................................t..sl...p.....sh.t............-..L........pG...........................c....p.......l.u.....s..t...p...G...os.................tp.p.h........lpp...........h.........................shp.l........................................................h.....p...h....s...s....h...s...ps...hp...................s....L....p....s...G......+...l...D.....u.h......h...s.....D....p....s....s....h....t...t....h...h..pp.p.s.ththhh................................ttthtsps....h...u...h......s......h.....p.......+.....s...........s.......s.......p.......L....h...p....t...l...sp...sl.t.p.....h...p.....p.....s.....G......p......h..p......p...l...p+a.h..t..........................................................................................................................................................................................................................................................................................................................	0	1937	3962	5901
+838	PF04144	SCAMP		SCAMP family	Bateman A	anon	Pfam-B_1298 (release 7.3)	Family	In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain proteins to the N-terminal NPF repeats but may have additional functions mediated by their other sequences [1].	23.20	23.20	23.30	24.00	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.13	0.71	-4.39	39	634	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	162	0	330	557	0	161.50	37	57.61	CHANGED	cpsNWP.Ph.t.h.htPhhYpDIssEIPs.caQ+hsphhahlWhhh............shsLhhNlluslshahts..ss...ussFuLullahllhsPsualsWYRPlY+AaR......................oDSuFsFhhFFhhahhplshslhtulGhPsh......GhsGaIsulshhps.shs..lulhhhlsshhFslpuslulhhlp+VaphaRtoG	.......................psNWP.Ph............htPhhap.DhssEIP....ch..Q..+hsphhYhhWhhh..........................slsLhhNll.usl.uha.hts.............su.....sssF......sLulla....h......l........lh..s.Psoal.sWYRPlY+AFR.......................................oDSuhpFhhFFh...hahhphshplltAlG.hs.....sh........................G.h..sGhlsu.l...sh..............hsp.....shs.....lulhh.h.lsshhFshtul.hu.......hhhlp....cVathaRtsG.....................................................	0	89	145	226
+839	PF02023	SCAN		SCAN domain	Bateman A	anon	Pfam-B_1614 (Release 5.0)	Family	The SCAN domain [1] (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several Pfam:PF00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerisation [2].	20.20	20.20	20.30	20.40	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.10	0.72	-4.51	62	2273	2009-01-15 18:05:59	2003-04-07 12:59:11	12	322	50	7	1114	1819	0	93.00	48	19.04	CHANGED	.ssEshRp+FRpFpYp-...ssGP+EALupLpELCppWLRP.EhHoKEQILELLVLEQFLoILPtElQsWVppppPcSuEEAVsLlE-Lpcphpcs.t..pts	....................st.EshRp+FRpF.pYpE.....ssGP+E.ALup.....LpELCppW.LR..P..Eh..+.TK.EQIL.E.LLV.....LEQFL..oILPtElQsWVpp.pp..Pc.SuEEAVsLlEcLppphpp.....h...............................	0	119	159	371
+840	PF02404	SCF		Stem cell factor	Mian N, Bateman A	anon	Pfam-B_2598 (release 5.4)	Family	Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified [1]. 	20.00	20.00	20.50	20.90	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.77	0.70	-5.20	4	137	2012-10-02 01:28:15	2003-04-07 12:59:11	10	3	70	16	36	126	3	171.70	49	93.19	CHANGED	MKKsQTWIITChhLQLLLhNPLVKTQu.CtNPVTDDVpDIsKLVuNLPNDYhITLKYVPtMDsLPsHCWL+.MVschShSLpsLLpKFSsIS-h...LSNYSIIspLs+IlsDLhACht.cpsKs.lKEsu+h.EpcpFhPEpFFplFNRoI-saK-.Fhsu.DpsDClh.Sos.TPEpDSRVuVTKsh.hPPVAASSLRNDS......SsSN+cAhs.IpsSSLQhhulALsuLlSLlIGFhhGAlYWKKppP.ShscosEsIQhp..pE-NEISMLQQKE+Ea.pV	.........................h....hhh.......tt..hN.lTsslpclshLhtNlPpDYhIslpYlst...lsshCWl...V.php.SLpsLhpKFsphSp......NhsIh.ph...h...............h.t..t.....t.h.stpaFthh..p.....hpt...s...s.cpu-Clh...sos.sPEp-scs.shopsh.hs..h..................................................................................................................................................................................................................................	0	2	5	15
+841	PF00188	CAP	SCP;	Cysteine-rich secretory protein family	Finn RD. Yeats C	anon	Yeats C	Domain	This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes [2] and non-vertebrate eukaryotes [3], The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins.  Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences [4]. The Ca++-chelating function [3] would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.57	0.71	-3.63	98	6534	2009-01-15 18:05:59	2003-04-07 12:59:11	21	194	2233	38	2946	5991	336	123.50	18	43.36	CHANGED	lshhNphR.....t......................stshhs.Ls...asss.LsphApppupphsp...........................tt.htpshspshthhthsst......t....................spshhtttpphptt..............htshh........sss..........sHhpplltssssplGsuhspssstt...............hhhlsta	......................................................................................................................................phhNthR....................................................stpt...hs.lp..........assp.LsphAp..t..a.u.p....ph.st............................................ps..hsp...s...t....s...p..s....h.t.....h.htt.hpt.....hsh..h........................................spshh.s.pt.pshshs....................................h.p.s.hh................ss.s....................GHh..s...p..ll.............s......s......h....s..plGsu....h....shsspt....................hhhsp.a......................................................	0	1119	1733	2458
+842	PF03803	Scramblase		Scramblase 	Finn RD	anon	Pfam-B_3893 (release 7.0)	Family	Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site.  Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury [1].	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.44	0.70	-5.26	10	783	2012-10-02 20:44:47	2003-04-07 12:59:11	10	15	285	0	512	771	22	198.70	28	69.98	CHANGED	Mousht.hsssPsuL-hLsphDsllVpQplEhlElhTGFETsNRYsl+sstGpplhhshEc.....SsshsRQhhGscRPFshclhDshGpEVhplpRPFpCss...p.....hssshppt-l....ps.sGssIGhVtQpWchhcspaclhsucp.psshplpuPssshs.sssspsF.V+oh-s.pllGpIsRpWsGlhREhFTDADsasl+FPh...........................DLslchKAVlluusFLIDFsYFEc	...............................................................................................................thp.hL.t.h.stlhlp.pp..h.E....hhp....................h....h.....h.....s..h..E..psN+Ytl.........h.......s.........s.............G.......p........t...l...h.h.....s.....hEc...................sshhsRp.h.h..t.....s.t.R......s...F......p..h..cl...............h......D.....s........h...........s....p...........c.........l......h.p..hp.R....P....hp..h.s......p....................................h.s.h..hpph.pl...................ps.s.s.Gph.......l..G..hlt...Q.....p..a....p.............h.....h................p..a....s.l.s......tpt...pp.............h........h............p...............l.......................G..........P..........h........h..h.........h..........s.....s...............h....ts....h.............s....F............pl.....hs...h.........s......t..p.............l......GpI.s....+....p....W.s..G.......h...h...p..-.h......h....T-..ss....pas..lp.F.sh...................................................................................................................sL..s.l..c.....+AlhluushhIDh.aFp............................................	0	214	284	400
+843	PF01390	SEA		SEA domain	Ponting C	anon	[1]	Family	Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain [4].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-10.06	0.72	-4.36	94	1758	2009-01-15 18:05:59	2003-04-07 12:59:11	15	244	103	4	1017	1679	0	104.30	16	14.60	CHANGED	sstthhphshpl.sshp.....asschpsssStpapslspplpptl...pphapps......ttahpsplhsh.........................pp........Go...llsphhlha.ptssststtshtptltpthpp....tthhslthssp	................................h.....hthsh.pl.sshp........aspchtsssStpa...ps...h...ppp...lp.phl....pp.hapss.........stat..ssplhsh................................ps.....................uu.....lhVphhhha..p.s.s.s.t.s...h..tt..h.p..h..p...t................h.......................................................................	0	253	329	554
+844	PF04091	Sec15		Exocyst complex subunit Sec15-like 	Wood V, Finn RD	anon	Pfam-B_7871 (release 7.3);	Family	\N	22.40	22.40	22.40	22.50	21.80	22.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-5.10	31	418	2012-10-03 17:31:52	2003-04-07 12:59:11	7	15	255	1	266	408	1	281.90	32	39.47	CHANGED	-Y-p.Vlphpahp........sptts.s...FPhhhPFSphhP.sCh.l+..........palsphhtFhsphhp.p.spls-.hl++shDpLLsch....lscslhphlpss....shpQlsQIllNLpaaEhAspplpphlsptptssps.ss...sph....tLpupcpapss++tAEpplhphlsoKID-hl.-hs-YD.Whs.spsss.-........sstalp-lspaLcshhsSshhsLPtplpphlhhcuhcHloppllsl.lLsssl+plsspultshshDlpaLEpFsspl......................................p......sssLppsFsEL+QplsLlhossh-.-a..........h-sshRt++YsRl.cspsuhhlL-Khp	....................................................Ych.lht...hp...........p.ph...pp.s.......FPthhPFSphhPthhh..p.l+.....................pFl.thhpFsps..hhh....p.splc-.hl+KuhshLLocp....lspsL.phlppt.....hsLspllQIllNhsahEpACp.L-phlsphp.sh.tp.ss..........tth..............................pLhut.ptF.+.ss...+.c.sAEppIh...phl.spKID-hl..ph...s-Y.D.Whs...scs..ss...c.................sSsYl...-lltaLcshh.ss.hptLP.t..........cltptshhsAhpHlusplh.....................ph.l..L.ss.....-.............l+plshsAltphslDlh.h..EtFsss.............................................p.......tspLp.shh-LRQhlsLhhs....shp.pa..........h-..u..p..p..+Y.+l.ss.pshhlLEKh...................................	0	77	136	208
+845	PF04815	Sec23_helical		Sec23/Sec24 helical domain	Bateman A	anon	Pfam-B_3055 (release 7.3)	Domain	COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.	27.80	27.80	28.00	27.80	27.60	27.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.03	0.72	-4.59	121	1420	2009-01-15 18:05:59	2003-04-07 12:59:11	10	28	326	24	936	1370	10	102.20	26	11.83	CHANGED	Q-Ahsshhu+pulp+shs....ss.....hp-........s+chLsppllclhspY+..phhtssssu.............lhLsp..shchhPhahhsLhKsthl.ps...tssssDcRsahhphlhshslpphlhhl	.....................................-Ahsslhu+h..Al.t+s.s.........ss......h.t-........................spc.hLsppllclhspat.......cht...tssssu.............................hhLsp....shplhPh...ahhsLh+o.phl.ps......h.......s.......s.......ssD-puahhphltp.slsp.hhhl.......................................	0	285	492	755
+846	PF04811	Sec23_trunk		Sec23/Sec24 trunk domain	Bateman A	anon	Bateman A	Domain	COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.	21.20	21.20	21.20	22.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.23	0.70	-5.01	22	1546	2012-10-10 16:07:06	2003-04-07 12:59:11	10	35	327	24	1024	1513	23	236.50	26	28.15	CHANGED	P.PslFlFllDlohs...su.LpslppulhpsL.shLP........spshVGhITasshl+hapls.sh.......ptsp.hsssclp-hh.......................hPhs.sphLlslpcschslpsLLcplsp.hasss..+csppshGsALpsAhtlLpss...sGG+lhlFtuu.sohGs.uhlpsc..cp...shhshcK-ttphhppsstaYcsLApcssspGhslDlFhhs.s.sslAplpslsphTGGplhhhsuFs.......sshFppshpRhh	............................................................................................................PshalFllDs.s..hp..........ps.lp..........slpps.lhts.L.....shLP.....................................sps.....hlGhlTa.s....ph..l.......ph.a...p..lttsh........................................................ptsp..h....s...s..s.p...l...p.-.h.h.............................................................................hPhs...sp.h.L..l..s.l..p..c..s..c.......................................l.ps....l.Lp...p...L.................p....ha..s..s..s.............................p........c..s........t........p..s......hG...sA.......LpsAhtl.lp..............................sG.G..+lh.....l............Ft..uu..............soh.Gs......s...h..lpsc..cp........................shhsh.s..+..-....................t.................t......h..h.......p..p..s.s...........t...aYc.pl.Atcssp...............p...............sh.......slD.lF.....hh.....s..........p...........ss..........l..................u..p..h................ts..............l.sphTGGphhhhssFp.............s..phhtpshp+................................................................	0	340	560	837
+847	PF04136	Sec34		Sec34-like family 	Wood V, Finn RD	anon	Pfam-B_16464 (release 7.3);	Family	Sec34 and Sec35 form a sub-complex, in a seven protein complex that  includes Dor1 (Pfam:PF04124).  This complex is thought to be  important for tether vesicles to the Golgi [1].	25.00	25.00	25.10	25.70	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.88	0.71	-4.53	3	293	2012-10-03 12:17:00	2003-04-07 12:59:11	10	9	255	0	211	309	1	151.10	29	19.38	CHANGED	cscch+cYLQsFpp...pCDpILsQlNuAhp+LtSLp-cY-FVSpKTSsLsEACEQLlcEQpRLsELA-sIQ++LoYFupLEpLNp+LpSPTLSVA.S-uF+EpLsKLD-CIsYIEENPcFKDuPtYLlKYKQCLSKAhcLhKsYslslIpQsT-QlLKcc	................................................h....h.p.Lpth...pp...ph-...t...l..Lsp.....sssslptLpsLpppaptVsscTsshpctC-pLLp-Q...pcLtclu-pIpppLpYFspL-slsp+L.s........u.........P..s...h..........u....V..s...scs.F..h.s.h.Lp+LD-Clsalp..s..H..........P..p......aK-ussYhh+a+phLo+AlpLl+sahsssLpph.spth....t.....................	0	71	115	174
+848	PF02889	Sec63		Sec63 Brl domain	Bateman A	anon	Ponting CP	Family	This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons [2].	33.60	33.60	33.60	34.00	32.60	33.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.13	0.70	-5.21	133	1940	2009-09-17 06:06:13	2003-04-07 12:59:11	11	53	348	4	1383	1943	35	302.80	21	32.16	CHANGED	sppLGcI....ASpYY..........lpapohphasp.....lps..pt.s.tc...........ll......pllotusEFc.....pl.lRppEcppLpcLh...pp.....hs....h.h.................p.tshpssps.....KsslLLQAalSR......h.plp...hsLhs................Dhthlhpsus.RlhcAhh-l.h.....hpcs........ahpsshtslpLsphlpp...............phW.s..pp........sPL.+Qhs.........................thsppl....lc....plcp...ps.h..ohpclh....ch........ssp-ls.......pllp...........p.upplhphlp...pa.Pplcl.psplpshscs..l.............................lplplplpsph.hp...................................th.st............t-saalhlt..D.scspplhthcphtl.....pp.............................tt.h....................lphslPhs.ss.......ph.hlhllSDp.alss.-pphslsh	.................................................................................hthGhl....suhYY..............lpapT.h...pha.p..........lps......ph...s.tc..................................llpllu.tus.EFc..............................p.l....l....R...p..p.E..c.....l.p.pLh.......pp......l.......h.h.....................................................ptph.p.s.s.ps........KsplL.LQ..........AaloR........h..pls.........hsLh..s..............................Dtt.hl...hp.puh.Rll..........p...Ahh-l..s..........................hpps..................ahpss..htshpLsphltp...................thW..s....pp..................ssL...pQls...................................................................................p.h.s.t.p..h..........lp..........phpp......................ts...h.......sltclh........ch..................psp.cht......................pllp..s...............p.hpplhphhp.......ph..P.p.lpl..ph..p...h.p..s.h.spp...h..............................................lplplplp.ph....pp.......................................................................................................................................................hh.tt..............t.csaa..l.hlt.............-.sps..ppl......h.t....h....chh.h............p........................................tth..............................................................................................................................hph....hP....t....................ph..hlhhhsDp.ahuh.-t.h.h....................................................................................................................................................................................................	0	481	779	1155
+849	PF04048	Sec8_exocyst		Sec8 exocyst complex component specific domain	Wood V, Finn RD	anon	Pfam-B_9576 (release 7.3);	Domain	\N	25.50	25.50	25.50	26.20	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.55	0.71	-4.55	22	297	2012-10-03 17:31:52	2003-04-07 12:59:11	9	8	250	0	211	305	0	126.60	26	13.09	CHANGED	pLppllsplphpWsthhpcsssPlplALphhD-oSlGhu+cht-FpphpcphppsLppVVs-HapsFNsuIuoYpplhsslpsSppcltplKptLppupptl.pscpspLpcLspsShcapchIplLstIc-lpplPs+l-ph	.......................................p..........................................D..p..s...s...s.ptpchtc....hpcthcphppsLcplVspHapshssuItoappIpppls................sSpp+lcpl...KpsLtpsKthL..ps........++.............s.............-L+cLhhcuhp......accllplLcpIE....plpplPp+lEt...............................	0	73	119	178
+850	PF00856	SET		SET domain	Bateman A, Huang S	anon	[1]	Family	SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) [2].  A subset of SET domains have been called PR domains.  These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction [3].  The SET domain consists of two regions known as SET-N and SET-C.  SET-C forms an unusual and conserved knot-like structure of probably functional importance.  Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure [5].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null --hand HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.85	0.71	-3.93	267	8450	2009-01-15 18:05:59	2003-04-07 12:59:11	23	382	879	153	5532	8290	1539	133.10	21	17.69	CHANGED	GhGlhApcsItpGp..hlh....phtupl..lstppspppttt.............................................................................................................................................................................................................................................tthh................................................................................................................hhhthtpththsstthsshucalNH...............SC.....................Nsthphh.................................tttplhlhAh+sIpsGEElshsYs	...............................................................................................................................................................................................................................................................................................................................................................hGlh.s.h...p......l...t...sp....hlh..........hs...h......ht.t.h.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................t.............p....t......h......h........h.....c......u....t........t....h....s.....s....h...u....c.......a..l....N..H.........................SC....pP............................N.st.hphh................................................................................tthpl.hl..h..A....h.....+...s.........I.....p..s.GE.ElshsY.......................................................................................................................................................................	0	1814	2953	4471
+851	PF03749	SfsA		Sugar fermentation stimulation protein	Bateman A	anon	COG1489	Family	This family contains Sugar fermentation stimulation proteins. Which is probably a regulatory factor involved in maltose metabolism. SfsA has been shown to bind DNA [2] and it contains a helix-turn-helix motif that probably binds DNA at its C-terminus.	25.00	25.00	29.70	26.60	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.26	0.70	-4.88	13	1762	2012-10-11 20:44:43	2003-04-07 12:59:11	8	9	1701	0	410	1213	1569	211.30	41	87.65	CHANGED	l+RhpRFlu-lpl-.GchhpsHhsNTGphptlhpsGspValp+u-sspRKhsashthspts..sphVslsTthsNcLstcAl..sttlspLs..astlctEVcaGppp...lDFLLspst..thaVEVKusTLscsslA.....hFPDAsTsRGpKHL+ELtpls+cG.aRullLFllh+sshcsFpPspclDPcauchlpcAhpsG.Vcllsapsphshp..lchsphlt	..................................lpRYKRFL..ADV....h.h.......s......s.......G...............c.....t...lThHCsNTGuMpGsh.p..PG.ss..Va.hS...p...S..-...s....s.K.....R...Khs.aohEls....ps......p...................G....t.....hlslN..Tt.hsNpLscEAlt...s..............t..p..............I..s........p........Ls..uY..s.......pl+pEV+..Y..G.....p...p+.......RID..F.h.....L.............p.....s...s.........s...............p......c....s....Y.lEVK......u......VT..L........t...c.....p.....t..h.u..................hFP........DA........lTpRGpKHL+ELh...shst..p........G.........p............RAlll..FsV.+ss.lpp.FsPuc.clDspY...AphLpcAt.ppG.VElLAYpsclospt.htltp...............................	0	139	263	348
+852	PF05002	SGS		SGS domain 	Finn RD	anon	Manual	Domain	This domain was thought to be unique to the SGT1-like proteins [1], but is also found in calcyclin binding proteins.	21.90	21.90	24.50	22.70	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.97	0.72	-4.23	48	564	2009-01-15 18:05:59	2003-04-07 12:59:11	10	29	330	3	345	531	2	76.50	36	24.80	CHANGED	spsWspLs..............h...pscc--cssp.t....................lsshF+plYpsuD-Ds+RAMhKSahESsGTsLoTsWt-lttt.h.....spsPcGhEhKca	.................................................t.psWDpLst...................hpc....p.p.pc-.ct-s..ssu................................LsphF+clYpcuD--h+RAMsKSahESsGTsLSTsWp-Vtptphp.....t..sPp....................	0	113	182	275
+853	PF03983	SHD1		SLA1 homology domain 1, SHD1 	Finn RD, Wood V	anon	Pfam-B_ (release 7.2)	Domain	NPFXD peptides specifically interact with the SHD1 domain. NPFXD is a clathrin-facilitated endocytic targeting signal. NPFXD was originally discovered in the cytoplasmic  domain of the furin-like protease Kex2p [1]. Sla1 is thought to function as an endocytic adaptor [1].  	21.20	21.20	21.70	21.90	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.21	0.72	-4.32	18	166	2009-01-15 18:05:59	2003-04-07 12:59:11	7	29	137	1	116	180	15	68.70	47	6.66	CHANGED	ossKScP-PpKlRoWoDRSGoFKVEApFLGhtDGKIHLHKsNGVKIAVsssKMSh-DLEYVE+lTGpSL-	........t..tcshPsst+sRpWoDRoGoFpVEApFlG.l.p.-GKl+LHK.h.NG.VKI.AVPlsKhSh-DL-YVE+lTG.SL-..............	0	44	72	103
+854	PF04925	SHQ1		SHQ1 protein	Wood V, Bateman A	anon	Pfam-B_11411 (release 7.6)	Family	S. cerevisiae SHQ1 protein is required for SnoRNAs of the box H/ACA Quantitative accumulation (unpublished).	20.80	20.80	21.00	21.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.08	0.71	-4.85	27	208	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	176	5	136	213	1	179.00	31	36.24	CHANGED	Lp...h.ppptp...............lpFocEEpcpht.plsp+paL.ls..p....tplhhsllslLaAYsYD.pps-G-pssE.SuWTIuKLoPplSaLDs.....................hssl+ssllsshRRuLsYPLaRsasLsp+sap-shhhLpu..GKphll+sLLcl+clF.p.hp-hhYlhsclalsDhhsWl..pss.s-phlpsLApclcpth..lscpp.......lp	...................................................................hpFoc-.Epp.ht.plsp+paL..ls..............pt..tppplhhsLl-lLhAYsY-hR.sspG-.pssE...SuWols.KLSssluah-p.......................hsslccslluhhRRsLsY.P.L..aRp...a...pLshpsh.pDshplLph...G..Kphll+sLL-l+clF..p..pp-........stYlhN...clalsDhshWl..pps.ppphlttLupplcph...lpKtt..s...................	1	53	77	115
+855	PF01549	ShK	DUF18;ShTK; 	ShK domain-like	Bashton M, Bateman A	anon	Pfam-B_662 (release 4.0)	Domain	This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges.  The domain is found in the potassium channel inhibitor ShK in sea anemone [1][2].	20.90	4.80	20.90	4.80	20.80	4.70	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.66	0.72	-3.59	157	2278	2012-10-02 17:51:16	2003-04-07 12:59:11	19	119	113	2	2009	2028	124	36.40	29	22.98	CHANGED	sCh....D.p......ssCsthssh....Cp...ss.....shhppp.CspTCs.hC	..................................Ch.......Dtt.......ssCst.h...sp.........Cp..............ss.............shh......p......p......p...CspoCs.hC...............	0	920	1083	1978
+856	PF04542	Sigma70_r2	sigma70_r2; 	Sigma-70 region 2 	Finn RD	anon	manual 	Domain	Region 2 of sigma-70 is the most conserved region of the entire protein.  All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant.  The core binding helix, interacts with the  clamp domain of the largest polymerase subunit, beta prime [1,2]. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation [1,2]. 	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.24	0.72	-4.37	259	39743	2012-10-04 14:01:11	2003-04-07 12:59:11	9	171	5036	49	11330	31962	8852	69.50	22	26.33	CHANGED	lhpph...hthl...hphutch....hsss....h.ss-D..LlQ-uhlthhcu.hcpac.ppu.p..hpsahhthhc....pthhc.....tlRc.pptt	.............................................hpth.hphl.....hp.h.u.t.+h.............hsss...............h..p...h..c..D....ll.Q-.shltl....h....c.......u....h.........c.......p.....a........c...............p.....p.....u................p........hpsah...hthhc....sthhc......tl+c.pt...................................	0	4421	8178	10016
+857	PF04545	Sigma70_r4	sigma70_r4;	Sigma-70, region 4	Finn RD	anon	Manual	Domain	Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1]. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.05	0.72	-4.65	130	17028	2012-10-04 14:01:11	2003-04-07 12:59:11	11	79	4776	54	4045	30085	7549	51.60	33	15.50	CHANGED	sLspLspRE+pllphRa....tpshTLpElGpthulocpRV+QlcpcAlp+LRp	.............................hLppLscR.Ec.pll...p...hRah.......................tpstT.LcEluc....p.h..s......l.oc.pRl+Qlcpc..Alc+LRp.....................	0	1461	2782	3486
+858	PF03145	Sina		Seven in absentia protein family	Mifsud W	anon	Pfam-B_1854 (release 6.5)	Family	The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non- neuronal cell type. The Sina protein contains an N-terminal RING finger domain Pfam:PF00097. Through this domain, Sina binds E2 ubiquitin-conjugating enzymes (UbcD1) Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination, while PHYL down-regulates the activity of TTK88. In turn, the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase, a process essential for R7 determination. It is thought that thus Sina targets TTK88 for degradation, therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue Siah-1 [1] also binds E2 enzymes (UbcH5) and through a series of physical interactions, targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53, itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation [2,3]. Sina proteins, therefore, physically interact with a variety of proteins. The N-terminal RING finger domain that binds ubiquitin conjugating enzymes is described in Pfam:PF00097, and does not form part of the alignment for this family. The remainder C-terminal part is involved in interactions with other proteins, and is included in this alignment. In addition to the Drosophila protein and mammalian homologues, whose similarity was noted previously, this family also includes putative homologues from Caenorhabditis elegans, Arabidopsis thaliana.	28.70	28.70	28.70	29.00	28.60	28.50	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.27	0.71	-4.65	10	1309	2012-10-02 00:06:50	2003-04-07 12:59:11	11	16	738	7	396	752	2	133.90	53	60.55	CHANGED	IRsLAlE.+lAsplpFPC+aushGCslp.LPhpphscHEEpCca+PYpCPhss..ucCpWpGshcslhsHLhscHpshhp.pus.-lhaltsshshstussWhhsp............................pCaGcpFpLhhEth-ts..ssphaashlphhGspcpAcpFuYcLELtu..spR+LpWQuhPpSI+-shcpshcup.....DsLlhpscsuphFucsss.....Ltl+Vo	........................................IRNLAME.KVAsS....V.hFPCKYA.........SsGCclo...LP...aT....EKs-..H.....E.E.l.CEF....RP.Y.S.C...PCPG.......ASC.KW.QG.S.L..-.uVM.sH.Lhc...pH..........KS.I.T..T.L...Q...G....E....DI....V.FL.A.T.D.I..N....L.P..G..A..V..D..WV.................................................................................................................................................................................................................................................................................	0	90	187	279
+859	PF04938	SIP1		Survival motor neuron (SMN) interacting protein 1 (SIP1)	Moxon SJ	anon	Pfam-B_5071 (release 7.6)	Family	Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans[1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.68	0.70	-5.01	12	252	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	189	1	164	243	1	206.00	24	72.25	CHANGED	LhPl-tsD.s.t-aD.osPPcsstEYLR+V...........phEAppCPsVV.lAplssp+.hc+cQoV.hsl.s......ss.ssPcshsPohcWp....ppQlspFspsRpslsph+pchpsp.lDssss.P..pDp-tWc+FCLscp.................................c.uhsPhLohlp+hsQ.sslsplLEhLstW.hpEcshssp......luRWlYALLACL-pPL.s-spSslRpLAR+CuplRst...Lcpc.......c.-plsshNLlIslluRaFsQpD	...........................................................................................................................................thp......Ppss.EYLppV............................................ph.EAtphP...pVh...lu.p.h.....s.......p...p...h..ppp....ps.s.......s....s..............................sh.....ss.tt....h......P.s....pWp....pt.ltpFpphRp.pl..tp............t............p..h...t.t...t...hs...t...p.....h....................t..spptWp.p.hhhspp...................................................................................................................................Phh......p..h.l...p..hs..p.tpl.t...l.l.p.hh.p.a...htppt..h..s..p............................................hspWlauLLspl-..p..P..L..scspuhlRpLsRp.C..p.lR........hptp..............................th......h.....s..h..hlslh.sph.atQ.............................................................	0	65	96	134
+860	PF03530	SK_channel		Calcium-activated SK potassium channel	Griffiths-Jones SR	anon	PRINTS	Family	\N	22.90	22.90	23.40	23.40	21.80	20.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.68	0.71	-4.27	10	342	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	90	0	179	301	0	110.00	53	20.18	CHANGED	RLt+R+tLaE+RK+LuDaALshAhhGIllMVlEsEL.ohtlYs+..........................................uShYShsLKslISlSTllLLuLIlsYHApEI..........QLFhlDNGA-DWRIAMThcRlhhIsLELllCulHPlP..Gsa.hasas	............................................................+Lt+R+tL.FEKRKR.LSDaALlhuhFGIllMVlEsEL...ohs...s....Y..sK.............................................tShaShsLKCL.ISlSTllL.LGLIlhYHA+El.................................Q.LF..hlDNGAD.DWR.IAMTh-RlhhI.sLEllVCAIHPlP..GpahF.W........................................................	0	35	51	113
+861	PF02437	Ski_Sno		SKI/SNO/DAC family	Mian N, Bateman A	anon	Pfam-B_2013 (release 5.4)	Family	This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].	20.00	20.00	21.50	20.40	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.50	0.71	-4.52	10	565	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	112	15	283	519	0	107.10	39	17.76	CHANGED	pP..P.hh...............SsPshssuDsssNEs+hlcLcGt+luuFlVsG-chLCLPQlFshhLKch..uLcplaT+lccLcIsslsCTs-Ql+ILRuLGAI.suVsRCtLIT++DhEpLhsshhsu	..........................................................s.....s..s...pss.pht.s.LcG.plusFh.l...sGpchlCLPQlhss.lLKch...ulpplas+hccLtIhs.spCss-QLcIL+s.hG.uls.uss+Cs.LIT+cDsEpLhpuhht......................	0	66	89	178
+862	PF01466	Skp1		Skp1 family, dimerisation domain	Bateman A	anon	Bateman A	Domain	\N	21.20	21.20	21.30	21.20	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.51	0.72	-3.95	62	1119	2009-01-15 18:05:59	2003-04-07 12:59:11	14	21	383	62	707	1038	25	74.70	46	40.61	CHANGED	lppWDt-Fl..pl..Dpp.....hLF-lIhAANYLsIcsLLDLsCppV.....AshIK.GKTPEEIRchFsIpNDFTP.EEE...pp.lRcENp..Wsh-	...............lppWDt.cFl...cl....Dps.....pLF-LI........l...........AA..NYLsIKsL.........LD.l.sCpsV.....AsMI.K.......G..K...o.......P.E.E...I.RchF.s.I.p.s.D.aTs..EEE..tp..l+cEstWs................................	0	222	328	583
+863	PF03931	Skp1_POZ		Skp1 family, tetramerisation domain	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.74	0.72	-3.87	17	1315	2012-10-02 01:20:04	2003-04-07 12:59:11	10	19	380	90	843	1197	12	61.60	32	39.07	CHANGED	phlhLpSSDscsFEV-ctlAhpStsIcpMlEDssssst......lPLsNVsucILsKVlEaCp+aph	.....................hlpLhS.oD.Gc..pFpVc.c.p.h..A.p.p.St.T.I....+.s...M..l....c........s.......s...tpsp..................lP.ls.N.Vsup....lLp.K.V.lpa.CpaHt.t................................	0	254	396	691
+864	PF00395	SLH		S-layer homology domain	Finn RD	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.04	0.72	-4.21	175	10758	2009-09-11 16:01:23	2003-04-07 12:59:11	15	704	543	2	2552	9714	348	43.60	29	13.80	CHANGED	sFsDlsstt..h....pslpthhptG.lhpGhs...ss........p....FpPspslTRu-hu	...........................FsDlssp..t.....ah.......ptl....ptl.s..p......t......G..llpGhs...........sG...............p..............FpPspslTRschA.............................................................	0	1376	2129	2319
+865	PF01423	LSM	Sm; 	LSM domain 	Bateman A	anon	Psiblast SMD1_HUMAN	Domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.91	0.72	-4.42	129	8102	2012-10-01 22:42:21	2003-04-07 12:59:11	17	62	2734	482	4356	6190	344	67.00	23	58.52	CHANGED	phLpphh.......sppVhlpLps..G.pplpGpLpuaDpahNllLs-spEhhttt.....................................ptt.l....s..hllRGsslhhls..	.........................h.....hh.......pp...V..pl..h..Lps........G..h.p.lp.G......p....l..p....ua..D..p.a..h....N..ll.Lp..s.spph..................................................................................................................................h...........t..hh..l.pGpslhhl...........................................................................................	0	1475	2432	3549
+866	PF02463	SMC_N		RecF/RecN/SMC N terminal domain	Bateman A	anon	[1]	Family	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle.  The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1].\	\	 This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.	40.00	40.00	40.00	40.00	39.90	39.90	hmmbuild  -o /dev/null --hand HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.52	0.70	-5.11	29	12849	2012-10-05 12:31:08	2003-04-07 12:59:11	14	52	4778	48	3915	12683	5334	665.40	15	93.51	CHANGED	hlcclhlpsFKSat.cplhhsFstsFssIlGPNGSGKSNllDAIhFVLG.p.supplRupphscLIat...............pstsssppApVplhF........sppspt.............p..hslpRphhpsGs...ScYhI........NGcsssh.p-ltcLLtptsIshpshphlh.tsthctlthp.spc+p.hc-tsuhsphcpttpcphpplhpppppttph.hphpphptphpphtpppppt.ch.t.ttt...ht..hhhhph..h.tp..p..pp..t.ptpp.t...t..ptptph.tp.pp..t.ppp..p..pt..t.htpt.tt.tpph.php.tp...ppthp.tppp.tphppphpttpt.h.p.pt..p.hthtp.t.ttthpphtp.tttt.tttpp..hthttttpt.ttt.p.ht.tht.h....pphpt..phtpp....hp.hhpt..t..tt.tp..ph..t..t.tptt....t.h..t.t...pt.tt.h.thp.h....t.....tt....t.....t....................h..................h............hh......................h............................................................................................................................................h....h.........t..................................................................p.........t.tt.......t.......h.p...t..t...t..ttp.t.h.tp..t...pt..ttt.h.th....pt....t.tp.tpt.ttp.pp.hpt.tpp.tt..tt.p.p....pp.t...pt.tthtpt.hpt.tht.....ptt..t..p.p...t..t.p...t.pt.p.h..t..t.htt.ttt.tt.pptpp....htp.t.t..pp.pt.t.p.t..h....t.tp..hc....t..p.t..t.p..t.p....t..ttht..tthp...h.th.p.t.p..t.t.phtph.tpcpchhphhhctpppphpphhtthsthspshpthhphhthuuputhphps.psshssGlphsspsssKphpplp.LSGGEKoLsALALlFA.....lpphcPsPhYlhDElDAALD.pNsptlAphl+..ppscp.uQFIVlol+pshhptA....-plhGlhh.csuhsp	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lpplplps.F.t..........sh..............c.p.......h.....p.....l........p......h.......p.....s.............u.........h.....s.....s.l...........s..G..........NGu...........GKSs...l...........l...-......A.......l.....t.......h.......s......L.......G................p........s...s......p.......p.................h........R......s.......s.....p.....h.......p.....s.....l...Itt.............................t.....s.h.......s....t......u.....p.......l...p....h...h..h.......................................pp.p.stt..................................................t.p......l.h.........l..p...R...p.....l.....t......p.....s..Gc...........o..p....h......h.....l........................N...s.....p..........t.......s.....p.....h......p....p.....l...t.....p....h...h......t.....p........h...h......l......s...h...cs.phhttt.p.chhhhp.tthpttht.ttthtphpphhcpppttlpptppptpphtthhp.hthphpthtttt.tttt..t...t...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.tt.httthtthtthhpttpphhtthhtthhth.pth.h.hthhhhhsptt.tths.pshhtsshphssp.stpth.hhphh.S.G...G..E..h.........s..hh.s....L......A...L..h..h..u................................h.t...p......h........p...s......t......P....h.....h...l..h.DEl.-usL.....Ds..t...p.t.p.t....l...u.......p...h.l....p.................p.....h...s.............t.............t........s............Q..h...l...s...l..o.....p...........t....h..h.t...u......p...hhl.h.......t................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1352	2437	3292
+867	PF04158	Sof1		Sof1-like domain 	Wood V, Finn RD	anon	Pfam-B_9404 (release 7.3);	Family	Sof1 is essential for cell growth and is a component of  the nucleolar rRNA processing machinery [1]. 	25.00	25.00	26.10	29.90	22.10	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.98	0.72	-3.96	28	344	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	289	0	240	346	7	85.70	41	18.60	CHANGED	AsASE+lGllosRE+puhpYsptL+E+apahPEI+RIuRHRHlP+slhptpch+pthhcAc+R+EcNc+pHSKsup...shhsE+cK..pll	......ApASE+lGlhssRE+pthpYscsLK-+apahPEI+RIuRHRHlPKsIhpAtchc+hhhc.up+RKEtNcR+HoK.sp..hshhsE+cKhll...............	0	88	137	202
+868	PF01033	Somatomedin_B		Somatomedin B domain	Bateman A	anon	Bateman A	Family	\N	23.10	23.10	23.30	23.20	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.47	0.72	-3.99	73	1147	2009-01-15 18:05:59	2003-04-07 12:59:11	12	76	110	24	540	1024	13	45.40	33	10.31	CHANGED	s.pSCpuR...Cspshppst..........tCpCcstChp.hssCCtDYcphChtphs	........................tSCp.sR.....Cscthttsp.......................sCpC-.spChp..hssCC.DYpphCttp.t.......	0	152	189	320
+869	PF03700	Sorting_nexin		Sorting nexin, N-terminal domain 	Finn RD	anon	Pfam-B_29150 (release 7.0) 	Family	These proteins bins to the cytoplasmic domain of plasma membrane receptors. and are involved in endocytic protein trafficking.  The N-terminal domain appears to be specific to sorting nexins 1 and 2.	21.00	21.00	22.00	29.10	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.82	0.71	-4.04	5	151	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	39	0	51	126	1	120.90	46	24.42	CHANGED	AuEREPPPlsDscsp........EsE.........-pEEGEDLFTSssSs.cossSSP-suslPuE-uS.TsSNGPKssplLLDDDcEDLFAEAT-EVSLDSPE...RcsILSopsSPAlTPVTPoSlIsPRlE.hu......aDRShEElEEE	.............AuER.PPPhsshcsp...........-...E.............p.p-GEDlFT.u.....ss.....s..s........c.......sp..ss.p...psu.LPhps.s.....S......ppN..G....+tpp...Dp-.pDLFA.....-..AT.ElSLDSsp.......+cs.....h.po.....S..ssp.s...T...s.o.oh.t.P................ohEElEEE..............................	0	2	7	21
+870	PF04130	Spc97_Spc98		Spc97 / Spc98 family	Bateman A	anon	Pfam-B_3531 (release 7.3)	Family	The spindle pole body (SPB) functions as the microtubule-organising centre in yeast. Members of this family are spindle pole body (SBP) components such as Spc97 and Spc98 that form a complex with gamma-tubulin. This family of proteins includes the grip motif 1 and grip moti 2 [1]. Members of this family all form components of the gamma-tubulin complex, GCP [2].	27.00	27.00	27.30	27.20	26.30	26.80	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.85	0.70	-6.19	120	1599	2012-10-02 13:20:28	2003-04-07 12:59:11	8	21	316	1	1118	1585	20	536.90	16	64.78	CHANGED	-l......LhsL.hGhs.s...hhphpt.........................tpaplspsh....................shps.............llpplhchuphapplp..pahp..tptt...................................uhhhpuhssulpphLp.sahp.hlspl-pphhp...............................................h.oLtplhthlp..phhphlphLtplspp.......h.....................................................t.tthpGuplLshlhpph....t.p.Gs......php.p....hhpplhppstpsa...hc.................................hlppWl..hcG......p....lp....D.....................t...E................FFlpps........................................tttpspphWpp.........p..........apl......pps......................................hl....P..................................sFl..psh...uppIlhsGKslshl+phstptthtpstt............................................................................................................................................................................................t.hp.hpssphpph....................................................................................................................................................................................................................................................................................................................................................................................................lppthphss..pplhpl............lhpph.cLh...pc.Lpsl+pa.......hLl....spG-Fhsphhpphtsplpcsspphpstphpshhptshttsssp......................................................................................................................................................................................................................................................................................................tptpthpttsstthtptpshpuhsshsLpYpls..hPLslll..otp............................slppYpplF............paLhpl++sp........htLs.phWtp.p...........t............................t..tth...hpph.......hhl+pchhpFlpslptYhh............h-......VlpssWpp.hppplp....................................................................................................................................pspsl-p.l......hptH.ppaLsslhppsh	......................................................................................................................................................................................................................................................................................................................................................................................................................hlhhh..Gh..u...hh..hp.....................................................th..h..t.......................h..s.pp...................................lhp.p.lhthu.hhh...tlp...pahp....t.........................................................................................................................u.hhpuh.ssul.p.p.hLp..paht...hlh.p.lcpp.h................................................................................................................h.oL..plhhhhp.....hhh.hh..ph..Lhtl..spph.........................................................................................t.hpus..tllshlhpth.........tp.Gs........................ht.p.................hh.plh.t.tst...psa...hp.............................................hlppWl....hpG...............................l.......D..........................s.................hp.......E................Fh...lppp..........................................................................t..tpphapp.............p......................................................apl..........ptp..............................................................................hl.......P...............................sa..l....tph......upplhhs.GKt.l...p.h...l......+ph......st....t....t..h..tt.....t...................................................................................................................................................................................................................................................................................................h......th.th.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lp.pthth..s....s.ptlh.ph..................hh.....p...ph...p.....Lh........tp.Lp.sl.+p.a.......hLh.....tpG...-hhtt..........hhp................h.....p........tl...p.p..s......p..t...h....t....h.....t...hp.s...h...h..p....s..ht..t..t....p..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....h...p...t...t...h..t..............................s.......t...shs.shpL.p.....Y.p.l.....hPlshll...s.p..............................shppYphlFpaLhpl+chph.Lp..ph....aht...........t.......................................................................................hpth..........................hhlptchhh.Fl.pplt.Yhh................hp............................llpspapp..h.pplp...........................................................................................................................................p.s.p.sh-p.l...hthHtpaLsphhtt.....................................................................................................................................................................................................................................................................................................................................................................................................................	0	419	621	910
+871	PF04435	SPK	DUF545; 	Domain of unknown function (DUF545)  	Finn RD	anon	Pfam-B_429 (release 7.5)	Family	Family of uncharacterised C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.	22.10	22.10	22.20	22.10	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.20	0.72	-4.09	37	379	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	5	0	372	368	0	102.60	21	29.69	CHANGED	hs+hMsFLl-pTKDs.sE...Pls.spplFp-Fsch-ssshs...tpsYhp+F+ppLAPpMsphssYSIEpRlRlMFuhuucVp--.FLpplcppGs.VpLD-ppRIs+YsSpDGplpL	.........................................h...hhpalhppspph..p.....Ph.....htplhcca.tpp.p.t.s..tts.............hpsh.hp....+hp..p..tl.t.....plpt...h.p.p....ashcs+l+hhFshus.sVs.p.....p...FL....p................c....L............c.p...p.u.p..V..p...l...D.c..p.pR...I..h.cYpu.pctth................................................	0	69	86	372
+872	PF04014	Antitoxin-MazE	SpoVT_AbrB;	Antidote-toxin recognition MazE	Kerrison ND, Bateman A, Finn RD	anon	COG2002	Domain	MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation [2], and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules [3]. MazF toxin functions as an mRNA interferase, cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest [4].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.13	0.72	-4.18	145	4979	2012-10-01 20:57:08	2003-04-07 12:59:11	13	18	1997	32	1417	3448	534	45.50	23	42.49	CHANGED	hpsssshtlslPpchtcph.....slct...Gcpltlhhp..ss..tlllp.hppttp	..............+hsppstlsIPpclc...cpl........slpt......G-plplhsp...ss..plllp.ht....st..........................	0	482	933	1183
+873	PF00622	SPRY		SPRY domain	SMART	anon	Alignment kindly provided by SMART	Family	SPRY Domain is named from SPla and the RYanodine Receptor.  Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.61	0.71	-4.04	68	8383	2009-01-15 18:05:59	2003-04-07 12:59:11	23	306	478	24	4618	6876	377	121.50	19	17.99	CHANGED	sG+aYaElcltstst........hplGhsppss..................................................................sttp...hsucc.tuauapstt.pphtssps........tthspthpp.........schlGshlDhpss....plsFt.tNGptht......hsFp.psphs...thlaPhhsht.....spthphphstht	.........................................................................................................................................G+aYWEVclsspst..............................htl.Gl...s..ppsh....................................................................................................................................................t...s...t..t..p.....h..hu.p...s....t...s..a.s...h.....p.h...p....s.......p..t...a...t.s.tps....................tph..s....thpt............................................scplGlh...l.....D.....h..csG.................p..ls.Fh...p.s.s.pt...t.............hhsFp......h...phs.............ts.l..aPhhsh.......................................................................................	0	767	1604	2913
+874	PF03105	SPX		SPX domain	Mifsud W, Bateman A	anon	Pfam-B_502 (release 6.5)	Domain	We have named this region the SPX domain after (SYG1, Pho81 and XPR1). This 180 residue length domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G- protein beta subunit and inhibits transduction of the mating pheromone signal [3]. This finding suggests that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 Swiss:P17442 from Saccharomyces cerevisiae and NUC-2 Swiss:Q01317 from Neurospora crassa, are also members of this family [see 4,5].  The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 [6] NUC-2 contains several ankyrin repeats Pfam:PF00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine leukaemia viruses (MLV) [1].  The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae [1,2]. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor [1].	26.90	26.90	26.90	26.90	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-4.62	168	2197	2009-01-15 18:05:59	2003-04-07 12:59:11	14	120	337	0	1617	2267	25	161.90	18	28.52	CHANGED	MKFu+pLppphl.....PEWpsp.....YlsYcpLKKhl.+plpptttpt....................................................................................................................................................................................................................................................................................................................................................................................ttpthpp........cspFhptL.-pELpKlssF....................................ap.......p+tp-hhc............+hp..........tLppplpphttptstttttt......................................................................................................................................................................................................................h.pthtpLcptlhchhtplptLcsatpLNhsuFpKIlKKaDKhh...spp..hptpahpphh	............................................................................................................................................................................................................................................................................................................h+Fup.h..t..................................ta....t........ahtYp..................hKp...l.h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.Fh....h.p.phtc.......l..a................................................................................................................p.tth...................................pht................h.......t.......................................................................................................................................................................................................................................................................................................................................................................................................................................h..th..thh.th..L.pa..............t.lNhhu.h.KlhK........KaDKhh..t..............t......................................................................................................................................................................................................................................................................................................................................................................................................................................	0	468	969	1406
+875	PF03125	Sre		C. elegans Sre G protein-coupled chemoreceptor	Mifsud W	anon	Pfam-B_352 (release 6.5)	Family	Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognised groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra Pfam:PF02117 and Srb Pfam:PF02175 comprise the Sra group. All of the above receptors are thought to be G protein-coupled seven transmembrane domain proteins [1,2]. The existence of several different chemosensory receptors underlies the fact that in spite of having only 20-30 chemosensory neurones, C. elegans detects hundreds of different chemicals, with the ability to discern individual chemicals among combinations [1].	20.00	20.00	20.00	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.17	0.70	-5.53	19	368	2012-10-03 04:04:29	2003-04-07 12:59:11	13	8	32	0	339	323	2	246.30	15	87.61	CHANGED	Mllphtss.....hhalPlahhspsh....hphlhslh-llhallssYlhhhslhlhh+lphFHpNhhhlslshhshWaEhllGKhlshsYchtlh....sht........hphhthWTs-.schl.VpshsslphlhhuuFLphHah.hohlaulhslslERshAShhlcsYEpps+haIs.lhLlhltQhluIshu..hhhlhphls.hlhhhhsahlssslushhahhlcphNpphppchcs.p.+...+..haTLSpRFQlKENl+sl+lhp+llhsllshlslsshslhhLhacl.....hP...s.hhsahhEshlhl.PhhIshshhholstW+pcapphhs.hhh...hc...hhptphthp.h.h.psppcphphETchYFpQLscSWp	....................................................................................................................................................................................................................................................................................................................h.....h......h...............hh...h.h......hh.hhhhERhhAohhhtsYE...p..p............p.............h........l...h.h...l......h.....h.h.......................hh........s..h...........s................h.h.h.h.........................h........h..............h...............h....h....h............h.....h.......hh.......h...........hh...............shh.............h.....h......h..h.h.hh.....hN.phh.p..p...h....p..t............t.............Yo.Lu.t+aQlpENl+.shp................hh..pt.h....h..h.s.h..h..h.h.h.h............h.h.hh.h....h....h..h.........h.p.h.............................hhhh.h...h.p.....h....hh..h..sh...hh.....s.h...hhh...............tap.p..h......h.....................................................................................................p......p.....aF..h............................................................................	0	115	150	339
+876	PF04086	SRP-alpha_N		Signal recognition particle, alpha subunit, N-terminal	Wood V, Finn RD	anon	Pfam-B_7342 (release 7.3);	Family	SRP is a complex of six distinct polypeptides and a 7S  RNA that is essential for transferring nascent polypeptide  chains that are destined for export from the cell to the  translocation apparatus of the endoplasmic reticulum (ER)  membrane [1]. SRP binds hydrophobic signal sequences as  they emerge from the ribosome, and arrests translation.	25.40	25.40	25.70	25.40	24.80	25.30	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.96	0.70	-5.02	27	323	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	265	2	237	320	1	243.40	23	40.50	CHANGED	ssslNuLIpsVhlEE+s.............usss.ap+-....paTLKaphspEhsLlFVslYQplLpLsalDKLLssl+phFh-hY..................cspLp..p.psph.th....pFcch.Fcphlc-hEpsupt.tpssphhpphcpppcs.hospshh...s...t.........tpp.tttptt.pspsssssssp.t..s.........lhstc.h......ppRt+hhtphtst...........sssscptos+pstts+...pshKchRhWDtsG.....spc-stsLDaS....t.ss.tt..ssssss.ptlstpshtptTtKGp.hh.tDl......s-Esc	.......................................................................s.tslNsLIpsshlp.ERs................usst.a..pp-.....thsL+aphsN-htLlFVssaQplLp..L...salDcLlssl+ph.FhchY........................tsplt...t......h.t............pFsp....Fpphl.....pph.Eppup....pts....t.h...pphpp....s.p.c.stt..s.stshh..t.st..t............................tttttttt...tt....t.....s...psp.s....s.ptt.....t......................h.ptchh...............ppRtchhppttt................................t.pts..p....t.s.....ppt.t..p...pttKp.Rh.Ws.su......pppstt.LDaS.........ssttt.....t....t....t.ht..ttphh.tp..p.G.p.h..h-h.........tp...t.........................................................................................	0	80	131	196
+877	PF00448	SRP54		SRP54-type protein, GTPase domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This family includes relatives of the G-domain of the SRP54 family of proteins.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-10.97	0.71	-4.87	55	11362	2012-10-05 12:31:08	2003-04-07 12:59:11	17	39	5002	94	3068	9263	5175	195.50	41	44.83	CHANGED	ssVIhhVGlpG..uGKTTThuKLAphhpcc...Gp+lhllAuDTFRuuAh-QLcphupphsl.hhs...tttts...DPsslshculppuKppt..hDllllDTAGRlppcpsLhcELpclpcll........pPs-slLVlDushGQsuhs.QA+sFp-sl.s.lsGlIlTKlDGsA+GGusLSlstthphPItFlGsGE+l.-DLcsFcscpals+LLu	...............................tVlhhlG.lp..G..sGKTTolGKLA...p...h.h.......p.....p........p...........s.............++....VhLsA.u..D..s....aR..s...A.A...l....-..Q..Lp.s.h.u...cp.....s..........s.........lslhs........................ttpss....cPss......l....sh.........c..Al.p.p..A..+....t..c.t.............hD..lll.....lD.T...AG.RL.p...h..c.......ps.LMpE.L.c.c..lp..csh...............................s.P..p.Esl.LVl.DAhT.G.Q.s.A....l..............s..p.Act...F..........s.....-........s............l...............s................l..o.....G..ll.L.TKLDG.s.A.+.G.Gs.slol..t...........p.....h.s.......h...P..I..+a.lGsGE+l..-DLcsFp..s-chsstll...................................................................................................	0	1055	2004	2604
+878	PF02881	SRP54_N		SRP54-type protein, helical bundle domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.47	0.72	-3.87	189	9665	2009-01-15 18:05:59	2003-04-07 12:59:11	14	28	4872	82	2570	7341	3204	77.20	29	17.42	CHANGED	L.ppsLp+shpplssp...hhh.sccpl..cchlc-lEptLlpADVuhpsspcllcpl+c.t....ht.............tptlsstpplpphlpcpL	...........................LpcpLpcohps..ltup...........shl..sccsl...c-hhcElctsLLpADVulplscchlppl+c.tlu................hcslssspplhcllp-EL.................................	0	854	1649	2165
+879	PF02978	SRP_SPB		Signal peptide binding domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.10	20.10	20.10	20.10	19.40	19.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.52	0.72	-3.77	124	4974	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	4793	40	1356	3784	2145	100.10	43	21.33	CHANGED	pFsLcDhhpQlpplpKMGslsplhpMlP.Ghsth......p.tp.ths.-+thc+hcuIIsSMT.cER..psPcll.................................ss...SR+pRIApGSGsslp-VscLl...KpapphpchM	...........................................pFsLsDFl-QlpQh+pMGshsslh....sMlP..G.huph.........t.t.p.phs..-+plp+hcAIIsSM.T.pER.....psP...-.ll.............................................ss.......SR++RIAtGSGsslp-..VN+Ll...KQFpphp+MM..............................	0	465	879	1145
+880	PF00436	SSB		Single-strand binding protein family	Finn RD, Bateman A	anon	Prosite & COG2965	Domain	This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.88	0.72	-4.16	70	10092	2012-10-03 20:18:02	2003-04-07 12:59:11	20	7	4898	110	2030	6702	2778	102.00	30	65.61	CHANGED	lN+VhL..lGpLspD..P-lRhst.sGsslssFolAssc...phps.......tsptcpps-ahplslasc.hAEhhspYlpKGs.hlhVpGcLps.cpapspp.G....pc+hss-lhsc....plphL	...........................................hN+VhL..lGpLspD......P.E..l......R.hss....s....G......s.....s.....V..u..shslAssc.......paps...................tsp.tc..cp.s-..a..hsllh..a...s....+....h..........A...E....s.........s.s.........p.....a.....l........p.K.G..s...hlhlpG.cl......p.......o..Rp..ap..spp..G............pc.c..h.s...sElhsp.....pht..............................................	0	640	1330	1739
+881	PF04503	SSDP		Single-stranded DNA binding protein, SSDP	Mifsud W	anon	Pfam-B_2031 (release 7.5)	Family	This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.	21.70	21.70	22.10	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.22	0.70	-4.67	5	325	2009-09-11 22:41:17	2003-04-07 12:59:11	8	5	59	0	134	249	0	206.60	62	77.49	CHANGED	EHSSEAKAF.............................HDYSAAAAPSPVLGNhPPGDGMPsGPlPPGFF..........................................................................QPFM....................SPRYPGGP.....RPPLRhPNQPsGGVPGSQPL.....LPuGMDPT.RQQGHP...............NMGGPMQRMTPPRGMsPL..GPQ................NYGGuMRPPsNuL....uGPGMPGMNMGPGuG...................................RPWPNPsoANSI.......PYSSuSPGsYVGPP.................................GGGGPPGTP..IMPSPADSTNSuDNMYTlMNsVPPGssRuNFPMGPGSDGPMGGhGGMEPHHMNG..............................SLGSGDMDSlSKNSPNNhSGLSNs.....PGTPRD.........DGEM..GGN	..........................................................................S.............AA.u.........A....PSPV......hG.shs.Ps.-u..M...ssGPh.s.P.GFF.....................................................................................................................................QPFM....................SPRas.GGP.....R..PslRhs.sQ....s.u..ul.PGoQPL.....LPsuMDPT.Rt..Q.G.HP............................sMGG.sMQR...M.sPPR.G..M..ss......h..GPQ.......................sYGu..uM..R..PP.Nu.L.............GP.u.MPuhNM.GPG.u..t.......................................................t.PWs..sP.su.NSI.......sYSSuSPGsY.s.GPP.................................GGGGP..P..GTP..IMPSPu.DSTNS......u.-NhYThhNs.lsP......GssR..sN......F....PMGPGs-.G.PM...uuh.u.uM..EsHHhNG....................................................SLGSGDhDul...sKsSPs.shu.hsN......PGTPR-.........DuEh..s......................................................	1	13	25	69
+882	PF05030	SSXT		SSXT protein (N-terminal region)	Moxon SJ	anon	Pfam-B_4900 (release 7.6)	Family	The SSXT or SS18 protein is involved in synovial sarcoma in humans.  A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes  at Xp11, SSX1 or SSX2 [1].	21.00	21.00	21.20	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.11	0.72	-4.39	9	329	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	133	0	185	312	0	63.70	52	20.29	CHANGED	RG............tsplsppslQ+LLDENspLIpsI.-YQNKG+AsECsQYQplLHRNLlYLATlADusps.hpspts	..................tls.ttIQ+hLDENppLIpsIh-hQN.....KGKss.....ECs.Q....YQphLH+NLlYLAoIADus.s.t...s.............	0	45	78	128
+884	PF01852	START		START domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.20	0.70	-11.09	0.70	-5.00	18	2507	2012-10-02 19:24:03	2003-04-07 12:59:11	14	50	457	40	1330	2394	50	186.50	16	33.31	CHANGED	plttpshpphhphspsspssWhp.s......t.pstspshpphs.s.........pscshRtpshV.hsss..lspplhcsh.....pWsppht....pspslpslssu.......sslphhhsphhs.sPlsP.R-ahhlRht+p.......ssssaslsshSlsssptss....ptshlRscphsSGhllpssssGh...........oplsalp+s-lcuphs..p.lh+slhpsuhshss+p..hhusLpptspp	.................................................................................................................t....................t....W............................h.t...h................................................h.h.h.+.h..........s....h...l.....hs.st.........h.ht....plhpp..........pWspphh.........................ph.p.ll.p.p.l.s.ss...........................stl..h....h......h..h..h..p..h.......h..................s...h..s..........s..RDh.l...h..l.R..hhpp.......................tss.s.h...h.ls.....s..h.....Sl..p.............ts........p........h.........s............ttshl..R...up....h....h.s..u.s..hl...l....ps....h...s..ss............................s.p....lsal..h..p..s-.........p...u...h.h.s.....t.l.hp.hhttth........hhp..h..............................................................................	0	408	676	997
+885	PF01740	STAS	SpoIIAA; 	STAS domain	Bateman A	anon	[2]	Domain	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.28	0.71	-10.12	0.71	-4.67	68	10190	2012-10-02 18:52:36	2003-04-07 12:59:11	16	126	3448	44	3587	10260	1791	111.40	16	25.99	CHANGED	thphpttssl....hllclsGs.lshssustlpcpltphhtpt...................................................................................phlllDhssl..shlDosGltslhphhcphp.ppusplhlssspspltch.........lptsuhh.chh..........plhtolppA	..............................................................................................................................................................................h........sh.......hlh.p.l.p.G.s..l...as..s.u.p.t.h.pp.p.l....t..p...hhptt........................................................................................................................................................................................ptlll..D.........hs.s.l..shlD.sou.l.p.s...L....tp..h.h......c....p.....hp........p..........p....u....h..p...........l.h.l..s...s......l......p..s..p...lt..ph.........lp.t..s.s.h...t...............................................................................	1	1204	2247	3019
+886	PF03015	Sterile		Male sterility protein	Griffiths-Jones SR	anon	Pfam-B_1115 (release 6.4)	Family	This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila.  A sequence-related jojoba acyl CoA reductase is also included.	21.40	21.40	21.40	21.60	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.03	0.72	-3.72	13	894	2009-09-15 11:21:16	2003-04-07 12:59:11	14	22	172	0	591	1002	19	92.10	26	18.78	CHANGED	haHhLPAhhhDlhhhLh..GcKPhhl+.la+KI+...pslslLphFshspWpF-scNhpcLppphs.pD+c...hasF.DhsslsWc-YFpps.lhGhRpYLhKE	...............................................hahlPAhhhDhhhhlh.......Gp...c.....s..h....hh+...lh..p..+lp.......cshph...hpaFsh.p...p.....W......pF.ss.sN...h.pp.L.h..p..p.....h....s...s..p.Dc.c.............hFsa.Dhpp...lcW.p..c.Yhpsh.lhGh+p.Ylh+-.............................	0	181	263	487
+887	PF02544	Steroid_dh		3-oxo-5-alpha-steroid 4-dehydrogenase 	Bashton M, Bateman A	anon	Pfam-B_1713 (release 5.4)	Family	This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor.  The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development [2].  In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally [2]. A related enzyme is also found in plants is Swiss:Q38944 (DET2) a steroid reductase from Arabidopsis.  Mutations in this enzyme cause defects in light-regulated development [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-11.02	0.71	-4.44	10	1178	2012-10-01 22:51:20	2003-04-07 12:59:11	11	15	411	0	741	1677	1096	142.80	25	50.78	CHANGED	sshPlhhlstAsh.FsshNGhlQuhahuaats........s-sahs..+hllGhhLalhGMhINh+SDpILR....pLRKsGpsuY+IPp.GGlFEYVSsPNYFGElhEWlGaALssWShsuluFAh...FohssLssRAhpHHpWYp+cF.ccYP+oRKhLIPFla	..........................................................................................s....h..hh.s....a.h.hs.h.............h..h...............................................h.....................t...h...h..h......u.h.hlF.h..h..u...hhNhpsc..hh.Lt..........................sL...R.....p......s......u......p..........p.......t...........a.....p......I.P......p......u......t....h.....F....p....h....VosPNYhhEl.l.t...W...l.u..............a...s......l.........h........s.........t.......s..........h........s.........s....h......h.....F....h...h.................h.s...h.....s.....p..hs..........h.....A.......h......t.p.....+....c...............h....Y...h...c..c.......F......p......c....Y....s.....p.p..R...t......s....llPalh....................................................................	0	231	405	592
+888	PF02910	Succ_DH_flav_C	succ_DH_flav_C;	Fumarate reductase flavoprotein C-term	Griffiths-Jones SR	anon	Structural domain	Domain	This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.29	142	8079	2009-01-15 18:05:59	2003-04-07 12:59:11	15	23	3914	101	2187	5856	3967	117.20	28	20.41	CHANGED	+pcLpchMpppsGlhRsppsLpcul........pclppL.pcch.p.p.ltl.t-puthhNssLhcslELtshlphAphhshuAlpRpESRGAHhRpD..aP.......................pRDD.................psah+HTlhhhttps..............l..phcsVphp.................PptRsY	..................................................pclpphMt.c.t.s....u.....l....h.....R.....s.....s.....c..tL.....pcu.l................ccl.p.t.l...p..pc.........h.........p.....p.........h.............t.............h....................c.............p.......s.............h.....h......N.............p.....s............h...h.p.sl...EL.t...shlplAphhshuAhtRcES..R..G...u..Hh..R.......D.....aP......................................cRs.D...................pah..ppsh.h........t.tt.....................h.th.p.l.............................................................................	0	688	1387	1840
+889	PF00884	Sulfatase		Sulfatase	Bateman A	anon	Pfam-B_784 (release 3.0) & Pfam-B_7393 (Release 8.0)	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.00	0.70	-5.24	59	18763	2012-10-03 20:55:17	2003-04-07 12:59:11	18	130	3819	26	4719	15548	10237	301.40	17	53.82	CHANGED	.sllllluEohtts....shshhuhsh...................ts...sPtl.........tths..ppGlhassha..ussshTssoh.shlouhs.tphs....................shhpp.sslsphhppt.GYpo.hht....shhspps.............................shp..hhsh.s.tsthtptt..shh................................................................................s.Dptlhsphhph.....hppt.scshalhlthhusH.................hhsscaspphtth.s.h.t.........................................................................phhssYssslthsDphlspllptL..pthtcsThllah.uDHG.tl......................................................th.htsttt.tt.ptthplPhllahssthtp...........ttscthhu....p.Dlhsollshs.uh	......................................................................................................................................................................................................................................................................Nllhl.h.....s-.shtht........................th.s.h...h..u.....th.............................................................TPpl.........stht................ppu...h...h...F.s.......s........h...a..........ss...s.........s......h....s........s..s.......o...h......s...s...h.h...o..u....h...h...sh.p....h...s...............................................................ths..tp...t..s...l.....s.p.h......L....p.....p...t....G..Y...p...o...........h....h.....t..t..................s....h.....h...s..pp.t........................................................................t.sa....p..........h...h......s.....................h.....t.....s....t...h.......t....t......t...........t..........................................................................................................................................................t..h..h.s...p...h....h.....h...p...p...s..h.phl...................ppp...ppPa.h.l....h.......lt.h.....hs.s..Hh.....................................................h.s...p..c.....a......p..p.....h.....t....t....h............................................................................................................................................................phhs.s..Y..h.s..s..l..p.....h..h....D.p...t.l...u...pl....l............p..t...........L.....c...p........p......s........h...........h........c...s...T.....ll..lah..uD..H.G..t.....h.tt...................................................................................................................................th.h.t..t..t..p..t.............h..h.....p..t..t..h....+...l...P..h.......h......lh..h..s..s..t..htt....................................th.pt.h.h.s..............thDl.hsTlhphh.s...........................................................................................................................................................................	0	1780	2902	3885
+890	PF00685	Sulfotransfer_1	Sulfotransfer; 	Sulfotransferase domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_87 (release 2.1) & Pfam-B_1885 (Release 7.5)	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.73	0.70	-5.14	45	4587	2012-10-05 12:31:08	2003-04-07 12:59:11	22	172	680	97	2665	5498	3822	230.10	16	64.36	CHANGED	ssDlllsoaPKSGTTWlpcllsh...............lhspsch....phhppshl....hsphPhlEh............................................................................shtphpph.uPR.lhp..oHhshthhs.shhpspsKlIYlsRNP+DshVShYaatphht.............hh.tsss..ap..........phh-hFhp..............GplshGsaacHlcsWhp..hppppplLalpYE-h+p-Pppplp+ltcFLGtshs......t.lppllcpsoFpshKss.ssshs...tt..........p.ssahRKGhsG-W...+sahTs.p.s-chDchac.......cphpsss	.................................................................................................................................................................................................................phhlhsh..+..s.......G...T..s...h.h..p.hlt...............................................................................h.p.ht....................p.p...........h........................p....h..h........h......l.p...h.............................................................................................................................................................t.......t.....h....t.....t...h.......................h.........................................................................................................................t...............p............s...K....l....l....h..l.h..R.s.P..t.-...h...h...hS...h...a..p..h..h..t.t.ht...................................................................................................t......hp...........................................ph.h.....p.....h.h......t.................................................................................s..t...h.......h.....u...........a...h...p....a....l...p...t...a...hp.................hh........t...p..p....l.......h..h....l..p..Y..E-........h........h........p......c........s....t..t...p...l...pc.l.h.c...F.L..Gh..s........................h...t....h...h..p..t..h..h.p.....h...p....t...........................................................t...h.h.tp..s......tth.........h..hs...t..t.hpt.h................................................................................................................	0	952	1358	1975
+891	PF03567	Sulfotransfer_2	Sulfotransfer2; 	Sulfotransferase family	Finn RD, Bateman A	anon	Pfam-B_3050(7.0),Pfam-B_5394(7.7),Pfam-B_7836(10.0),Pfam-B_5040(7.5)	Family	This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST).  Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development [1].  Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.78	0.70	-4.70	66	2144	2012-10-05 12:31:08	2003-04-07 12:59:11	9	38	506	1	1196	2133	483	218.30	15	67.30	CHANGED	pchhlssca.pllaChlsKsusoshpplhhhLts.................hpps.phs.....pshsp.p..h...ptthtphsphp.pph.tpthp.t........................................hhpFhhVR............cPhcRllSuapsKhh.........htphh.upphhphhc................t.....t.spapcFhphlhstt.......pht......hsp...H..............ats.....htp.hshsshh..cachluphEshp....cctshlhphhsh....shth....phsp.................pppppsssphttphhhphs.thhctlhclYph.DatlF.sYs	..........................................................................................................................h...........ll.ahhl.Ksusosht.phhh.h.h.t...........................................................ht.......th....................tth.h.......................................p............hh..ph....s.ph.....tt.......ht..p...............................................................................................................................hhhhhhlR.............cP...hp...R..h...lS..t...a.h..t.h.h..........................t..h.........t.t..h.hpthp..............................................................t....hshp..p...F.h.p...h..l.h.s.t....................t...........s.............p......................................................h.....................ht..h.p.....h..h......pa.s.h.l.Ghh...E.php............pp..h.t....h.l...p.h..h.sh...............h...........ph.t..............................................p.......t.......h..t.h......h..s.........t.hphh...phh.h.Dh.ha.ta.............................................................................................................................................................................	1	489	622	928
+892	PF04935	SURF6		Surfeit locus protein 6	Moxon SJ	anon	Pfam-B_5497 (release 7.6)	Family	The surfeit locus protein SURF-6 is shown to be a component of the  nucleolar matrix and has a strong binding capacity for nucleic acids [1].	22.00	22.00	22.10	22.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.72	0.70	-5.04	29	306	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	262	0	222	303	4	204.60	26	49.88	CHANGED	hppRptllcp+R++cctc+p+++.pcRpct+ppcp...spcsctpsspppttts................................pssstpstsslsFsplpFs-sptsspshphhcpptpph.......t..shKphLp+lEs++p+LpphcEp..............Ktt-lc-KppWppAhh+AcGhKl+DDp+LL+KALKRKEppKcKSppcWpERpppVpcphppRQKKRc-NLpcR+csKtpK+hppt.+pKG..+hh	...........................................................................................................s....thhpt++p+c.ctc+t++.+.pp+p.ct+tccp...........tpc.tp.t.t.spttpt.t..t.........................................................................tpsttp..tssslsF.uplt..hs-spths...pphpphp..p...t.t.t...............p....shcp.hL.pclct+cp+Lpplccp..............Kttclcc..KptWpsAht+AcG.K.....V+..D...D........cLL+KulKRK-ppKcKSpcc..Wc-RpctVpcph....pp....RQcKR...c...c.Nlc.pR+cpK....t..p++hppt.ppKt.................................	0	74	123	186
+893	PF01805	Surp		Surp module	Bateman A	anon	Bateman A	Family	This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding [1].	21.10	21.10	21.10	21.10	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.50	0.72	-4.31	64	1689	2009-01-15 18:05:59	2003-04-07 12:59:11	15	52	309	8	1115	1679	12	53.40	30	10.94	CHANGED	.hplIcpoApaVscpG.pFEt....hlhp+p...ps.spFsFLp..ss.sshasYYph+ltphp	................hplIc+hAp.F.VA..+..sG......p..FEp......hlh.p+p.....tpN..sp.........F..s.FLp......sp.ss....hasYYph+ltph..............	0	351	557	826
+894	PF02201	SWIB		SWIB/MDM2 domain	Bateman A	anon	Bennett-Lovsey R	Domain	This family includes the SWIB domain and the MDM2 domain [1]. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the  p53 binding domain of MDM2 [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.54	0.72	-4.30	41	1464	2009-09-11 13:54:42	2003-04-07 12:59:11	13	39	457	79	836	1368	324	74.50	28	17.21	CHANGED	hs+.h.lo.pLtphlGssp...h.oRs-llctlWpYIKp+sLQDPpsK+hIhCDppLppl..Fts.cp.lshhplschLspHhh	..................................t.htlsspLtp..hl....Gtpp.......h.oRspllptl.WpYIK.........ppp....L.............QD.sps+.......+.h.....Ih..C.D.cp.Lpp.l......Ftt...pp......l...phh.pl.schl.stah.......................	0	228	451	658
+895	PF04434	SWIM		SWIM zinc finger	Aravind L	anon	Aravind L	Domain	This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organised into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (Pfam:PF00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts [1].	19.60	5.00	19.60	5.00	19.50	4.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.58	0.72	-4.45	88	3643	2009-01-15 18:05:59	2003-04-07 12:59:11	12	91	1791	0	1241	3096	130	38.50	23	6.69	CHANGED	apVplt......................ptsCoCthaph......pthsCpHhlAlhhtht	.............................................................tspCo.Cs........................tsh.hC+Hhlulhh...h...........	2	294	711	981
+896	PF04433	SWIRM		SWIRM domain	Aravind L	anon	Aravind L	Domain	This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins.  It contains a helix-turn helix motif and binds to DNA [1].	26.10	26.10	26.10	26.20	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.82	0.72	-3.86	79	1274	2009-01-15 18:05:59	2003-04-07 12:59:11	12	43	286	28	857	1242	5	86.30	27	11.90	CHANGED	hhhsshu...shhshs.plpphE..pphhschhh..................................ssp...sYlphRshllppa..phpssphLshoss..........+csht......Dsstlt+lapFLpcaGhINa	.....................h....shsshhsh..s...pl.pshE..pphhschhtt....................................................sPp....hYLshRshhl..pp..a.....phs..st.th..Lshsss..........+pslp.........DlstltRl.asFL-phGhINa...........	0	243	449	684
+897	PF00804	Syntaxin		Syntaxin	Bateman A	anon	Pfam-B_1158 (release 2.1)	Domain	Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A (Swiss:O35526) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role. The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors [6].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.23	0.72	-3.86	171	1633	2012-10-03 05:55:03	2003-04-07 12:59:11	20	15	425	9	971	1702	19	101.60	21	33.55	CHANGED	thspF.....hppspclppplpplppplp.clpphp....pphhshss..tp..................................phppclcplspplpp...hh.......pplppplc.........p......lppt..............................ttsssstphppsph.pslspcFpchh	........................................spFh.pp.spcIppplpp.lppplpclpphp...................pphlssss...sp......................................pphcpcl-pLstpIpp.ph................pplc..pplc.........................s...........................lppp......................p....................tppt.tspssssh+htpsp....hs.....sLupcFh-lh...................................................................................................................................................	0	281	496	740
+898	PF00907	T-box		T-box	Bateman A	anon	Pfam-B_363 (release 3.0)	Domain	The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations [2].	20.50	20.50	20.60	20.60	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.08	0.71	-4.81	22	2143	2012-10-03 00:25:27	2003-04-07 12:59:11	17	23	269	9	1083	1755	0	155.30	47	35.04	CHANGED	plpL-spcLWpcF+plsTEMIlTKoGRRMFPsh+lploG....LDPpuhYhlhlDhVPsDspRaK..assucWhsuGKAEPpsP.sRhYlHPDSPssGu+WM+pslSFpKlKLTNst...sssGp.l...lLpSMHKYpPRlHlVcs..ss..s..........ph.hpTasFPETpFIAVTAYQNpcITpLKIcpNPFAKGFRDs	...........................h.LptttLWtpFp........p..h..s..sEMIl..T.K.t.G...R.....R..........M....FPshchp..l..sG....Lc..s........pspYhl.hhD.h..lss..D...s.....p...R.......a+.............a..............p..s..u....p........W..h...s.....u...G...K.....A........-......st....h.......s...............s.R.....h...Y.............l....H..P....D...S...P...s...s...GtpW..........M+....p....l.SF.....pK..l..KL..........T...........N..............N....h.............s.....p....p......G........p....l.....................lLpS.h..HK.Y..pPR.l...Hllcs..sp..t..................................p.t.hpoasFs.ETpFhAVT..AYQNp..p................ITpLKI.cpNPFAKGFR-...............................................	0	218	311	758
+899	PF04719	TAFII28		hTAFII28-like protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4085 (release 7.5)	Family	The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex.  The conserved region is found at the C-terminal of most member proteins.  The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits.  The conserved region contains four alpha helices and three loops arranged as in histone H3 [1,2].	18.90	18.90	18.90	19.70	18.50	18.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.85	0.72	-4.19	10	332	2012-10-10 12:36:46	2003-04-07 12:59:11	9	8	271	2	230	363	2	87.60	40	33.70	CHANGED	hQhLlosFocEQhsRYEsaRRSuhpKuslK+Llsp...lTG.polupsVlIulsGlAKVFVGElVEpAhcVpc..Epp-os.....PlpPcHlREuh+RL	............................tlLlssFoc-Qh.sRYEhaRRou..hsKu..slK+Llps.........ls.u.....p...SVspNVs..IshuGluKVFVGElVEc...........Ah.sVpc......cht..-ss.............................slpPp+h+cuhh......................................................	0	73	122	187
+900	PF04177	TAP42		TAP42-like family	Wood V, Finn RD	anon	Pfam-B_5735 (release 7.3);	Family	The TOR signalling pathway activates a cell-growth program in response to nutrients [1]. TIP41 (Pfam:PF04176) interacts with TAP42 and negatively regulates the TOR signaling pathway [2].	26.00	26.00	27.00	26.70	24.90	25.60	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.09	0.70	-5.49	39	389	2009-09-11 05:02:27	2003-04-07 12:59:11	7	7	295	3	263	396	3	308.00	25	90.82	CHANGED	sLpphFppuhphhs.plcp....ts..psosphQsplp...psIpphpcspphl.spLuLFSsNEslE-luTssLpYLhlsYaLupLhp+..................ssspRhphLptupphatpFLsphcsYc.llstp.tchhcph.............st.hs...shsssstpRptKIppaKpcKELcp+Lphlcpthpp.............................psD-E.............hRchaLspLphhhhcohppL-tlspElpl.Lpthtphttpst..........................................pphhc..............t.h...lsppspsLpPF.......hl..........hs.pRpphpppVFGsGas.LPTMol-Eah-pEhcpGthhcst......tpp.................ps.ppct.....c-cc.EpsDcEsh...+.sRpWD-aK-sNP	...................................................l.thattu.phht.tht.........t.s.u.thpp.t.lp...pslthhppstphl....splu.LFSsNEsl--luTssLpaLh.lsahlupLh.+..............................hs.spRhphLptup.......thhh......pF...LphhcpYp.l..ls.p....phhpph.............................t.......shsshstpRptKItpa+pp.Kc....l...cp+Lp.........tlcpthcp...............................................................psD.-E.....................hhRch..alhplphhhhp......uhppl-.lppEhph.Lpth.t....ttt.stpt.....................................................................................t.h.....tttstsl.p.sF...........hl......................pRpph..ptpVFt...sGas.LPTMol-Eah-pchcp....Gth.ptt........ttp......................tt.ppp..........p-pp.......-.......psDpcph.....+..sR...tWD-....aK-sp...............................	0	91	141	208
+901	PF03943	TAP_C		TAP C-terminal domain	Bateman A	anon	Bateman A	Domain	The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [1]. The structure of the C-terminal domain is composed of four helices [1]. The structure is related to the UBA domain.	21.30	21.30	21.40	22.60	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.40	0.72	-4.54	8	365	2012-10-01 23:03:33	2003-04-07 12:59:11	8	19	218	4	263	372	0	49.80	36	8.36	CHANGED	QEMlpAhSsQSGMpl-WSpKCLpDNsWDYs+AupuFspLpscscIPtEAFt	......phltthoppouMshcaSppC.L.p.p.s.sW...saspA..hpsFp.plp....spspIPt-AF.......	0	74	111	185
+902	PF03134	TB2_DP1_HVA22		TB2/DP1, HVA22 family	Mifsud W	anon	Pfam-B_837 (release 6.5)	Family	This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein  (e.g. Swiss:Q00765), which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein (e.g. Swiss:Q07764), which is thought to be a regulatory protein.	27.20	27.20	27.40	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.26	0.72	-4.24	93	1350	2009-01-15 18:05:59	2003-04-07 12:59:11	14	26	310	0	844	1293	9	90.30	32	38.56	CHANGED	hshhupllss.lhGhlYPuYtShKAlcos...stp......-sppWLsYWllauhholhEhh.sshhlt.WlPhYahhKhhFllW......LhhP.pspGAphlYcphl+Phh	........................................................h.....phls.lhGhhYPu..YtShKAlcop.....shp........................-.ppW.lhYWllauh.h.ol.h..Ehh..s.......chh....l.......s..W.........h..P....hYa.hK..h.........hFllW......LhhP...tsp...G...uphlYcphl+Ph.................................	0	265	450	669
+903	PF00352	TBP		Transcription factor TFIID (or TATA-binding protein, TBP)	Finn RD	anon	Prosite	Domain	\N	22.90	22.90	23.10	23.00	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.62	0.72	-4.62	135	1985	2012-10-02 11:58:57	2003-04-07 12:59:11	16	8	584	132	1141	1872	373	83.40	38	62.81	CHANGED	tss.hpIpNlVAosslst.plcLcpl.uhph...css...-YcPE.pFPGLlaR....hp..cP...KsshL.IFsSGKlVlTGuKs.c-sppA.hcplhphLpchs	................................................................h..phplpNlV.uossl..........th..plc.Lcsl.Ahpt......ppu..........pYcP.......-....hF.su.l..I.hR.........hp....cP..................+....sshLIFsSGKlVhTG.AK.......s..cc-.sthA.hcphhtllpch.................	0	351	608	909
+904	PF03148	Tektin		Tektin family	Mifsud W	anon	Pfam-B_3069 (release 6.5)	Family	Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organised as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are  predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components [1].	25.10	25.10	25.20	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.31	0.70	-5.92	37	1118	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	349	0	335	991	0	261.70	40	82.81	CHANGED	WppsNhtphppupspRspuc+lpp-oppLhpEsptpTppsQpDssc+LspRlpDIphWKpELpcplcchtsEhstLtp.KpRlEcALpshp.hPlslsp-CLphR-pRhuh.DLV+DpVEpcLhKEl-lIcsspplLpcslppshcQlph.Rsu+ppLEhDhsDKhpAhpIDspChpL.sNsSsslpapssss+hs.......ssss..o.csWtcFoppNlp+Acp-ctsStpLRphl-plLppsusDlcsQtsssshAFppRlpEhpcA+scLchpLtcshpEIsptEcsIptLccAlp-KpuPlKVApTRL-sRot.RPNVELCRDpsQhtLlsEVpplpsolptLpp+LtpAcssLpsLhcpphpLEc-lthKpNSLhIDc.+ChphRpphss	............................................W+cNN..pYphospupccActLch.po++.hpcshsshshp.cDSs+K.LspR.............IcDlshWKcclp+slpslscEIspLcc...........sRs+LcsAhchLh.hP.uI.ucECLcL...........Rs..sRhcs...DLV.+D.-uEpEL.l..KE.Vslltpl++lhhsTL.s+s-EQh...h....hN....................+uAKpslEhDaSD..KhsuLcl.....Dc....cstsL......ssp..S.shl...a.+s...G.ssRhs.....................ps...so....o......E.......Wtcas....pt.........................................................................................................................................................................................................................................	0	101	127	224
+905	PF01397	Terpene_synth		Terpene synthase, N-terminal domain	Finn RD, Bateman A	anon	Pfam-B_728 (release 3.0)	Domain	It has been suggested that this gene family be designated tps (for terpene synthase) [1].  It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.	20.20	20.20	20.60	20.30	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.24	0.71	-4.91	141	1399	2009-09-17 01:05:38	2003-04-07 12:59:11	16	21	224	56	399	1601	0	164.00	29	30.94	CHANGED	WscpF.l..............sasst........cphhpplcpL.+pcV.+p.hl..s.sts.....phhppLpLIDslpRLGluaHFcpEIc.phLcplapp.htppp...tt...........DLassALtFRLLRpaGapVSsD.lFpcF.+-cpGp..Fpp.shh..sDs.+GlLsLYEAo.aLthcGE..s.lL-EAhs.FoppaLcphh...ttps..s.............L..spplppAL	................................................Wt..hh............tht............pphhphh.p.p.L..hpch.....pp.......hl..s..sh............shhppLphlDsl.....pRLGlshaFcpEIc.p.hLpp...la.pphtpps.........................DLh.ss.ALtFRLLRppG..a.p...V.........S..s..-......lFp.pF..pcppGp...Fp.........t....sh.........t.......pD.......s..cuhLsLYcAo.pl....t.h.p.uE..p..lL--Aht.FopphLcphht...p.p................LtpplphuL..............................................	1	37	241	326
+906	PF00440	TetR_N	tetR; 	Bacterial regulatory proteins, tetR family	Finn RD	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.07	0.72	-4.32	109	63222	2012-10-04 14:01:11	2003-04-07 12:59:11	18	89	4528	525	17576	49863	3840	46.40	26	22.51	CHANGED	IlpuAhclhs.ccGapssohpcIAcpAGlupuslYhaFs.uKcpLhtsl	....................llpuA.h.p.l.ht..p....p....G.....h....p....s...s..o.lpc....lAc..pA...G...l...s..p..u..s..l.Y.p.aF.....s..sKcsLh.t.....................	0	5211	11622	15040
+907	PF03850	Tfb4		Transcription factor Tfb4	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Domain	This family appears to be distantly related to the VWA domain.	21.00	21.00	22.10	22.10	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.08	0.70	-5.14	26	353	2012-10-10 16:07:06	2003-04-07 12:59:11	9	8	279	0	253	344	4	246.40	33	81.47	CHANGED	sSLLsllLDTNPptWsphppp.......hslopslsu........llVFlNAHLuhNpsNpVAVlAupsps.scaLYPssp...............tsspsshshst.st.............shY+tF+hV-Etlscclpplhppsstss.psp.....ohl.uGALohALsYINRh.p.spu..........................................pphpSRILl....lsuspDsshQYIPlMNsIFuAQ+hplPIDlspLsG..DusaLQQAuDsTsGlYl+.lsp.....scGLlQYLhhuFhsD.ptRshllLPspssVDFRAuCFC..H++llDlGaVCSVCLSIFCph..P........CsTCs	...................................................................sLLslllDssPhhW.t....ht..............................hslsphlts................lhsFhNuHLhhstsNplAl.lA.u.p...pt....spaLYPs.s............................................p...p.t....t................................shap.hp.hpphlhpplpplhp.p.sp.t.........t.t.....s.t...........ohl.uGuLuhALsaIsRh.p...h....t...............................................................thpuRILl........lps..up-ts.QYhsh.MN.s.lFuAQ+.....plsIDsshL.....ss.....sushLQQAschTsGlYlp..s.t.p.....................tu...LlQYLh....h...sF.h...s.......-.......p.....Rp....l.......h.h.........P..s........s.p......VDa...R..A..u.....CFC.Hcpll-lGaVCSlCLSIaCp.....s..........C.TCt...............................	1	84	138	210
+908	PF02269	TFIID-18kDa	TFIID-18; 	Transcription initiation factor IID, 18kD subunit	Bateman A, Mian N	anon	Pfam-B_3681 (release 5.2)	Family	This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold [1]	20.90	20.90	20.90	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.04	0.72	-4.17	6	572	2012-10-10 12:36:46	2003-04-07 12:59:11	11	6	281	2	396	577	1	87.00	33	36.04	CHANGED	phappElpsMMYuhGDspcPhsETssllE-lVps.lhElhppAhclup.cttpplplEDlhFLIR+D.tKlsRl+chLohp-hhpKstKphD-	....................h..att-lpphMauhGD.......s.......p.......p.......PhsETssllE-lVhp.lh...............-hhp.....p.A....tpl.....uppp......t.t.p.......p...l.psEDllFLlR..+..D...tKluRlcchLphp.-.hp+stKs.-t....................	0	122	205	319
+909	PF03847	TFIID_20kDa	TFIID_A; 	Transcription initiation factor TFIID subunit A	Griffiths-Jones SR	anon	PRODOM	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.07	0.72	-3.69	8	348	2012-10-10 12:36:46	2003-04-07 12:59:11	8	10	262	2	243	431	8	68.60	45	16.48	CHANGED	oK+KLp-LVppl.....DssspLDs-VE-lLL-IADDFV-SloshuCpLAKHRKScpLEs+DlpLHLERsaNh	...................sK++Lp-LV+pl................DssppLDs-.VEEh..LLplADDFl-sVsstAC.pLAKHR+Ss.....sLEl+DlQLaL....ERsaNh.................	1	81	131	200
+910	PF04494	TFIID_90kDa	TFIID_WDA; 	WD40 associated region in TFIID subunit	Bateman A, Wood V	anon	Pfam-B_9152 (release 7.5)	Family	This region, possibly a domain is found in subunits of transcription factor TFIID.  The function of this region is unknown.	20.60	20.60	21.20	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.59	0.71	-4.13	35	427	2012-10-02 14:46:49	2003-04-07 12:59:11	10	17	260	14	300	411	3	132.80	27	19.44	CHANGED	sp.hstttp-s..cPppYtpuYshL+sWl-soLDlYKsELp+.lLYPlFlasaL...-LlspshsppA+..pFasca+s-ap.hHsp-..lppLpslspspHlc-NphAptapssKYplplocsuasLLlpFLpcppss...llltllspals	...........................s........pssPtpYpptastL.+pal.cs.s...L.Dh.a+h.ELpp.l.LYPlFVahaL...cLVtsshtpcA+........pFap+..apspa.......tt....app-......lcpL.p.s..........lpp.p.c..........l..ppNph.h..p..tacssKahlplocsua.................phLhpaLpppppt....hlhtllppal...............................................	0	91	144	231
+911	PF04253	TFR_dimer		Transferrin receptor-like dimerisation domain	Bateman A	anon	Bateman A	Domain	This domain is involved in dimerisation of the transferrin receptor as shown in its crystal structure.	21.00	21.00	21.40	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.45	0.71	-4.55	36	850	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	269	58	560	820	42	119.80	23	16.83	CHANGED	slohp.lhpAhppapcsupphpphhcphc..........psshltl+h....h..NcplhplE+sFlss...hGlPs.+sha+HVlauPs.hs..ts........toFPultDultptp................WspspcQlsllshslpsAAstLtts	.................................................t.lshp.LhpAhtpappsupphpp.hhp.php.........................................pp.s.h.th+h......h.......Nc+.....lhh..lE+sFls........................tGl.P.s.Rsaa....+Hl.lau......Put.hsthss.................psFPulh-ulpptc......................hspspcplshhshslpsAAthL...s......................	0	150	267	427
+912	PF02824	TGS		TGS domain	Aravind L	anon	Aravind L	Family	The TGS domain is named after ThrRS, GTPase, and SpoT [1]. Interestingly, TGS domain was detected also at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly  beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role [1]. 	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.68	0.72	-4.13	61	10557	2012-10-03 10:59:06	2003-04-07 12:59:11	16	41	4800	19	2820	7605	3711	61.10	35	9.24	CHANGED	ltlah.PcGphhc........ltpGuT.shDhAhtIHpslucphhhAhVsG.......p.hlslsphLcssDllcIls	.......................lhlho..PcGslhc................lspG.uT..slD...hA.h.sIH.s.s.lucpsluA+..VNG.......................................c.hVsLsp.Lp..sssplEIlT.......................................................	0	893	1705	2346
+913	PF00763	THF_DHG_CYH		Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_882 (release 2.1)	Family	\N	21.60	21.60	21.70	21.70	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.28	0.71	-4.06	105	5546	2009-01-15 18:05:59	2003-04-07 12:59:11	18	17	4681	28	1648	4097	2479	116.10	41	35.35	CHANGED	pllDG+tlAppl...ppcl+pclpplptp..sh.PpLulllVG-csASphYVcsKp+tspclGlcsphhplspshopp-LlshlpcLNpDsslcGIllQLPL..Ppplspp..pllpsIsPcKDVD	...........................................llDGKtlAp...pl...cpcl...tp...cV............pt..l..........pt...........p........s....hsPu...LA..VlLVGs...c.........P....A.SpsYVpsKp+us..cclGh.pS............phh..cL..........P...p...s.....s....o.............p........p.......EL.LshI.ccLNpD.s.slc.GILVQLPL.......P.pp......I..D...pp...pllpsIsPcKDVD..........................	0	523	1025	1369
+914	PF02882	THF_DHG_CYH_C		Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_882 (release 2.1)	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.02	0.71	-5.16	91	5651	2012-10-10 17:06:42	2003-04-07 12:59:11	14	24	4719	28	1679	4648	3203	157.80	45	48.31	CHANGED	HPhNlG+Lsts..ps....shhPCTPtGlhcLLcp.hsls...lpGKpsVVlGRSsIVG+PluhLLhp.........p........sATVTlsHSpT...csLsphs+pADIllsAsGpPphlpu-hl...KsGAlVIDVGINRl..........tss+.LsGDV-F-sltch.AuhITPVPGGVGPMTlAhLhpNTlpuAcpph	..................................................................................HPhNlG+Lhhs........ps....shhPC.TPtGlh.p.L...L..c.........c......h....s.l......c..............lpG+.p..AVVlGRSs...I.......VG..+PhuhLLLp........................t.....................s.A.TVTl..sH...op......T...................+s...L..tp..h........s...c.......p.......A.D.....Il.l...sAl.....G.+.......P.p..h........l........s..u...-.h...l..............K............G..A...l..VIDV.GlNRh.................................tsu+..LsGD..V..c.a.......-.s..s..tch..A..u.h.I..TPVP.GGVG.PMTlAhLlpNTlpAscp.h....................................................................................	0	539	1040	1395
+915	PF00899	ThiF	ThiF_family;	ThiF family	Finn RD, Bateman A	anon	Pfam-B_59 (release 3.0)	Family	This family contains a repeated domain in ubiquitin activating enzyme E1 and members of the bacterial ThiF/MoeB/HesA family.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.59	0.71	-4.34	90	12207	2012-10-10 17:06:42	2003-04-07 12:59:11	16	111	4208	117	4344	10198	2664	134.50	27	37.94	CHANGED	ppu+VlllGsGGlGuhssphLAts.Gl.....GpltllDtDpl-hSNLsRQhlaspsc..l...Gp..sKspsAppplpplNP.plp..lps....hsptl...................stpshppll.......t..sh..D.....lllDu........hDs..hssRhhlsp..hshpt.............th.P...hlpuush.shtups.hhh	............................pu+Vlll..Gh.G.G..lGu......ssphLA...t...u...G..l.........................Gpl..s..l............l..............Dh......D....s..V...c....ho.N.....L.pR....Q..h..l.h...........p.....p....s..s.....l....................Gp...........sK...s.........p.s.s..tc..p........l.......p............p..l......N.....P......p..l.p.......l.ps....hpp.tl............................................s.t..p..s..h...p..p...hh....................p...ph......D...............lV...l.D..s.................hD.s......h.p..s...+.....h...h...l..sp...hsht.t.......................p.h...P.....l.lpuush..uh.......hh...............................................................................................................................	2	1492	2600	3620
+916	PF02597	ThiS	DUF170;	ThiS family	Morett E, Mian N, Bateman A	anon	COG2104	Family	ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer Swiss:O32583. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS [1]. MoaD, Swiss:P30748 a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.42	0.72	-3.55	145	6781	2012-10-03 10:59:06	2003-04-07 12:59:11	15	34	3470	44	1951	4749	1939	72.90	24	84.19	CHANGED	lhh.uphpchss............tstTltpLlppL....s.hph.....................ptltltlNtchlpt.....sp.l..pcGDplsllPsVuGG	...................................................................hh.ut.tphhs...........................t.s...t..Tl.....t.pLlppL.....t.tpt..........................................ptl..t.lul.Np...p..hl..s.......p.................s.......p.......hl................p-GD......plsl..lssVuGG.......................................	0	625	1287	1677
+917	PF01833	TIG		IPT/TIG domain	Bateman A	anon	[1]	Domain	This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognise a significant number of members.	20.90	19.70	20.90	19.70	20.80	19.60	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.09	0.72	-3.99	131	8379	2012-10-03 16:25:20	2003-04-07 12:59:11	19	516	691	126	5044	7498	871	86.60	18	16.26	CHANGED	Pt.lssls..P...ttsssts.GstlolpG..psF........................tssssplhhusttsssh............hhssspl.................hspsPsts............su.shslplthss............tssshsapa	.................................P.lpslp.....P.......ppu...sh....t.....G...G....sp.......loI....pG......p.s...h..............................................................t.s.ss..h..p....V.....h.l......u..st...t...sssh...................................hhss.spl..........................................................hCps..Psts..........................su..th..p.l.plthss.............................................................................................................................	0	2483	3116	3961
+918	PF04280	Tim44		Tim44-like domain	TIGRFAMs, Finn RD, Bateman A	anon	TIGRFAMs (release 2.0);	Family	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane [1].  Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region [1].  This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast.  This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane [3].	29.60	29.60	29.60	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.54	0.71	-4.22	140	1637	2012-10-03 02:27:23	2003-04-07 12:59:11	10	10	1251	4	675	1440	1309	139.80	19	44.40	CHANGED	sutul.p.thpph-ssFssppFlpuA+stath.lhtAaspGDhcsL+shlop-hapthppslsp+.tptG..............shcsphlslpcsclhpuphc..sspshloVcFhsp.hth.hcpts.Gpll-G....s.spspchp-lWsFsRs......hsss.sssWpLsuhpp	..........................................................t.....t.hhths..ssFs....ptF..lptscphah..l.tA...a.s..p.s.-.........h....cs....l....+.p.hhotphas.thpt....tl...ppt..t.G.......................t.psp...l.tl.hps.c.l..spsphp.............sst..shlolp....h..p...h...h...h.t.t..s.....G.plhcG..........sts.ps....p.p......hp-lW..shsRs..........tst...tssWhlsshp......................................................................	0	200	377	531
+919	PF04176	TIP41		TIP41-like family 	Wood V, Finn RD	anon	Pfam-B_12821 (release 7.3);	Family	The TOR signalling pathway activates a cell-growth program in response to nutrients [1]. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway [2].	25.00	25.00	27.20	26.60	23.00	22.20	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.01	0.71	-5.03	29	320	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	281	0	224	312	3	175.30	40	57.53	CHANGED	MlFGcNhlpIpH.poGhsIcFNAhDALctVcppsp..sl+Vuhuc-WpcSRppsp.tp...........................-hlKPaDWTYTTsYpGTlhs...............ttthhhpsosccIslc+LpptDPILFaD-llLaEDELuDNGIShLSlKlRVMssphhLLhRFFLRVDsVLhRlpDTRlYh-Fsp......shllREapp+Essacplpp	.........................................................MlFGsNhlpl....pH...........tsGht..lpFNAhDALctV.......p...p....pt.......t..............l.+V..uhupcWp...poRppsp....t.t...............................cll.+PaD.WTYTTs.YpGTlts..................................................t.h...ph...p.sosp..pIsh-tL..p.pp.-.s....ILF.a--lhLaEDELsDNGlShLSVKlRVMP.s.s..hhLLhRFFLRlDsVLlRlpDTRlYh-Fsp...........shllREapt+Esphppl..p...........................................	0	72	123	186
+920	PF01582	TIR		TIR domain	Bateman A	anon	Pfam-B_571 (release 4.1)	Family	The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (Swiss:Q99836) and TOLLIP (Toll interacting protein, Swiss:Q9H0E2). In turn, these associate with various kinases to set off signalling cascades [3].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.52	0.71	-4.74	45	4612	2012-10-02 18:56:14	2003-04-07 12:59:11	15	676	330	18	1819	5111	86	129.70	23	17.89	CHANGED	sFlsaps...........cscctFlsclhppLccp.....uhplalcp+.hhtGtphhss....lhpsIccS+hslllhScsaspSp..WC.LpELhphhcpthp.s..plllslFhpVcspclp.....pppscatpshtpthph.tsc.............tphthW+pshts	..................................................sFlsapt......................csp..ph.h.....h...s...cLh.....p....L...c...p.p.................s.h..p..l...h.l.c....c.+......-......h.........s..G....p.p..l...h.ss...............lh.p.u.I..c.........p.........S+...p.s.lh.VlS....ps....a.....sp.......Sp.............W..C...h..E..hh..h........h..h...p......p.............h..h...p...p......t.............t...p..l.l....l.h..l..h.....p.l..s.........p.plh...............tp.h.p.hh.h...thp...p.h....h....p...h.pp.....................tp....hWpphh..t................................................................................	0	512	992	1303
+921	PF03920	TLE_N	TLE_N-terminal; 	Groucho/TLE N-terminal Q-rich domain	Finn RD	anon	DOMO:DM01627;	Family	The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerisation.	24.00	24.00	25.20	24.00	23.60	21.00	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.83	0.71	-4.34	15	565	2009-09-11 00:33:27	2003-04-07 12:59:11	10	14	92	0	240	496	0	119.50	69	20.92	CHANGED	MaP..tsRhsuPtp..........suQP..FKFTluEoCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQuEIsKRLNAICAQllPaLSQEHQQQVsQAVERAKQVTMsELNulIG..........pQ.phQpLppt	......................................s.s..p..........suQs..hK.FTl.sEohDRIK-EFQF..LQAQ.YHSLKl..EC-KLAoEKTEMQRHYVMYYEM.S.YGLNIEM.HKQ.sEIsKRLNs.IhA....Q.llPFLSQ.E.HQQ.QV.sQAVE.RAK.QVTMsELNAIIG..................QQ..hQ.hQpLSp.t.................................	0	38	56	155
+922	PF05154	TM2		TM2 domain	Bateman A	anon	COG2314	Domain	This family is composed of a pair of transmembrane alpha helices connected by a short linker.  The function of this domain is unknown, however it occurs in a wide range or protein contexts.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.55	0.72	-3.75	142	3044	2009-01-15 18:05:59	2003-04-07 12:59:11	11	50	1798	0	887	2110	350	53.80	28	26.67	CHANGED	pt+shhhAhlL.sl..h..LG.hhGlHRFYlG..phtp.GllhLlhh........Gh.hsl........h.hlsh.l	.......................pshhh.uhlL..ul...h..........lG..h...h....Glc+FYhG...phtp.Glla.Llhhh.................Gh.hsl...................hhllp..h..................................................	0	311	541	742
+923	PF03348	Serinc	TMS_TDE; 	Serine incorporator (Serinc)	Mifsud W, Mistry J	anon	Pfam-B_3473 (release 6.5)	Family	This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid [3].  Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis [3].	20.30	20.30	20.40	20.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.65	0.70	-5.77	45	847	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	289	0	501	781	10	343.80	29	92.34	CHANGED	usCCGu...usCshhCosCsus...psShsTRlhYAhlLLlsollShIMlsshh.ppLp+.h.tas....................thsC....sp......hhGahAVaRlsFuluhFahlhullhlsV+SS+DsRAslQNGFWhhKhlhhlulhVsuFa.IPs.shFhhhhhaluhhGuhlFILlQLlLLVDFAHsWuEshlp+hE........-ssS....+hWhshLlssThhhYhsSlshslLhYlaas...ssuCshNphhIolNLllslllSllSlpPpVQEhpP+SGLLQuShlolYssYLTaSAloscP....D+pCNPh.............................hpspsshssshllGhllhhls.....lh.YoohRuussop....................................sshltLssc..............p.sh.p.cspshptssc-Gs.spps.......................hDsEcsuspYsYShFHhlFhLAohYlhhhLT.....................sWapP..tp.h...lsps.asusWVKIsSSWlChhLYhWTLVAPllhP-R.F	...............................................................................h.t...h..........psh...sRhh..Yshhhh.hsshlshlhht...h..h.t.l.....c.....h....h...................................................................................sC........t.........hhGh.uVaRls...huhsh.....Fah.........lhslh.h..ltlp..ss.......p.ss.R..u..t.lpN.G.aW.hhKhhhhhshhhhsFh.l........Pp...t.a..........h.........hh.hhluhhGu.hhFlllQLlLll-FAHpW..scthhtphc................pt..............phWhhhLhhsThhhY...h..h..uhsh.hs....lhaha..a......s..........................ts...Ct....Nphhls...hshhls.hhhohlul.P.......t...lp........t....P.p...........uGLh.Q..uuhlshYshYL..sa.SAhsspP.....pptCss...............................................................................t...tt....sh...llGhhlhhhs......lh.as..s.hps.uspst.............................................................................................tt........ts...............................tsE.pps.s.YsYuh.FH.h...hhhLA.ohalhhhLT..........................sW.....hp....................sp.....ht...ht..ts....h.shWVKl..s..ssWhshhlYh.WoLlAPh.h.h..pR.........................................................	0	149	252	373
+924	PF03459	TOBE		TOBE domain	Yeats C	anon	Yeats C	Domain	The TOBE domain [1] (Transport-associated OB) always occurs  as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately  after the ATPase domain.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.78	0.72	-3.86	81	5980	2012-10-03 20:18:02	2003-04-07 12:59:11	12	16	2667	79	1494	5716	620	62.60	25	27.64	CHANGED	suspNhltupVtslcttu...sps.Vplplusst....lsuplot...pussp..ht.Gpplhshl+sspltl	...................SsRNtltG...pl...s..s...l..pp....ss.........spscV..p..l..p..ls..ssp..............l.h.At.l..os........puspcL..tL...p.sG..pplhAhlKuspVh.........................	1	339	843	1182
+925	PF04265	TPK_B1_binding		Thiamin pyrophosphokinase, vitamin B1 binding domain	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1].	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.24	0.72	-4.26	86	1995	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1908	31	487	1399	315	67.10	24	29.30	CHANGED	Gp.ahlphppsh..................paluhlP..lssssp.lohpGhKYsL.......s.spshph..Gsh.hssSNch......tpp..splolpsuhsl	...................................t....lp..tsh..........................pYluhlP..ls.s.sp..lolpGhKYsL..............s.stshth..sss..hssSNEhh.....spp...splohpsGh....................	0	183	311	409
+926	PF04263	TPK_catalytic		Thiamin pyrophosphokinase, catalytic domain	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1].	30.70	30.70	30.80	30.70	30.60	30.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.54	16	2336	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	2211	33	581	1714	474	120.30	26	51.60	CHANGED	N.p..thPt..hhps...ppschhl.usDuGusph...hth.......................slhPchhlGDFDSlsc.Ehhshhtpt...sphlhhs..-KDpTDh-hAlphs.......hphsts.clslhGuhGG.RhDHhh.......uslthLh..+h........s..hpshplhlhsp	........................................................................................ht......................pp....s..h.hl.usDtGu.hl...hch..................................................................slh...Ps..hhlG.D.....FDS.lsp..-..h.ph.h......tpp..........ht.p..h.h..h...s....-K...D..pTDhplAlphs.......................................hp.h.s...s...p..lh...lhG...A..hG...G..RlDHhl.......uNl.lhh..p...........................................................................	0	229	386	496
+927	PF00515	TPR_1	TPR;	Tetratricopeptide repeat	SMART	anon	Alignment kindly provided by SMART	Repeat	\N	22.90	13.00	22.90	13.00	22.80	12.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.34	0.73	-7.61	0.73	-4.14	555	18473	2012-10-11 20:00:58	2003-04-07 12:59:11	23	4566	3183	236	9338	112617	30616	31.90	20	6.62	CHANGED	spshhshGhsahphscaccAlpsapcAlplsPsp	.......................hhhphG.h.s.a..h..p....h....s.....c.......a.p...pA.l..p.sap.cAlphp.......................	0	3602	5574	7522
+928	PF01938	TRAM	DUF90;	TRAM domain	L Aravind, Bateman A	anon	L Aravind	Domain	This small domain has no known function. However it may perform a nucleic acid binding role (Bateman A. unpublished observation).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.89	0.72	-4.18	30	8506	2012-10-03 20:18:02	2003-04-07 12:59:11	15	36	4435	5	2131	6354	2315	60.00	24	13.59	CHANGED	pphlGpphcVllcshu...ppGpshu+spt............sphlhlpss....ts...G-hVcl+lpcspp..phLpGcll	.............................sphhp.lh.l.cshu..............ptGp....h..l...G+..sc.....................................spsV..hlpus.........................hs....GchV....cVcIsc..spp..p.hhucl...................	0	721	1386	1802
+929	PF00486	Trans_reg_C	trans_reg_C; 	Transcriptional regulatory protein, C terminal	Finn RD	anon	Pfam-B_94 (release 1.0)	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.37	0.72	-4.06	362	52522	2012-10-04 14:01:11	2003-04-07 12:59:11	23	271	4715	43	11355	34159	7239	75.80	30	29.75	CHANGED	spp........lpL.ospEapLLphLhppssc.lloRcpLhc..plWstsh........ssspsl-lalppLRcKlcs....s.ts................phIpTl+GhGYph	..................................p...lpL.T.s.p.Eap.LL.t...hL.h....p.....p..s.......s....c......lloRcpLh...c..........pl....W.s.hsh...............sssp..s..l.-VaI..p+LRcKlpp.......s.ts................................ph.Ip.Tl.+.G.hGYph..........................................	0	3440	7162	9460
+930	PF02458	Transferase		Transferase family	Bateman A	anon	Pfam-B_1540 (release 5.4)	Family	This family includes a number of transferase enzymes. These include anthranilate N-hydroxycinnamoyl/benzoyltransferase that catalyses the first committed reaction of phytoalexin biosynthesis [1]. Deacetylvindoline 4-O-acetyltransferase EC:2.3.1.107 catalyses the last step in vindoline biosynthesis is also a member of this family [2]. The motif HXXXD is probably part of the active site. The family also includes trichothecene 3-O-acetyltransferase.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.32	0.70	-6.04	11	3130	2012-10-02 12:01:53	2003-04-07 12:59:11	10	37	323	17	1766	3103	5	327.00	17	84.89	CHANGED	hpVphpppplIpPupPTPpp...pL.LShlD..hltssh.hs.shaFYcpssphspph........shcpL+puLScTLstYYPhAGRL.....sschplsCNs-G..s.FVEApucsp.Lp-hhch...sssshphllsphssspps.s...hPLhhlQlTpFcCG.GlslGhshsHplsDuhShspFhpsWAchu+ut...t.sssPsas+phlhsp........tsPps....hs.h......hssspptsscchlpKphsat....pssplccLpp+ussppsss...........................TphEsloAhlWRshsputptssppp.......sslhhslshRsRls.P.LssuYhGNshhsssstpss..u-l.pp.lshssctlpctlpp.lsc-hhpsshshsts.........hhhpthscsshh..ssalloSWs.+hPhh-lDFGWGpPlassssssshtsts....hhhPsp....tsssGltlhlsLspppMstFccchphh	.......................................................................................................................................................................................................................................h...........................................................................ht.tu.ht.h.L......a.....h..sGph...............................................................................l................................s...t.......u..............h......h.h.............s.......................................h....t........h.................................................................................................................h...............................................................................s....lh.h.......hQ.l..o.....h........t.s.........G.....u..........h.hluhthp..H.......hh.h.Duh..uhht....Fh..psh.u....p.h.s....ps........................................s............h....p....p...t........h..................................................................................................................................................................t......................................t.....................h.....h.h.........................p.......t.l.t.....t........h..t....t...t.....h.......t....t...................................................................................oshps.l...sAh.l....W..p....s...h......s.....t...u...h....t....h...........t..t.............................sthh.h...shs.....h....R.....t....p.....h........t......s...............l.....s.........t......s......a.h.........G.....N........h.h......h........h....s........h...s....h.ts..................tp.l.......h......t.........t..........s..........l..t...............h.......s....t....h.l..p.....p...t.....h..t.......t..........h.....p.....t......t...h..h..p..t..h...h..p.hht..............................h..........h.........................h....h...h..s.s.........p..h..s......h...h..p..h..D...F..G...........h...........G.............p.............s......h.h...t...........................................hh.......................tt..t......h...h...h...h.....................h.....................................................................................................................................................	0	148	963	1430
+931	PF01336	tRNA_anti-codon	Aspartyl_tRNA_N; tRNA_anti;	OB-fold nucleic acid binding domain	Bateman A, Mian N, Finn RD	anon	[4]	Domain	This family contains OB-fold domains that bind to nucleic acids [4]. The family includes the anti-codon binding domain of lysyl,  aspartyl, and asparaginyl -tRNA synthetases (See Pfam:PF00152). Aminoacyl-tRNA synthetases catalyse the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a heterotrimeric complex, that contains a subunit in this family [2,3]. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.29	0.72	-4.12	640	22969	2012-10-03 20:18:02	2003-04-07 12:59:11	20	145	5024	111	6345	20485	6498	80.20	20	12.26	CHANGED	lplt.Ghlpsh.................+st.sthhalp.....lpDts...G......plplhhhp......................tthhphtpplp......sshltlp..Gplptp..........tts..........................hplhspp......lphl	.............................................hpltGhlhpp................+st.up..h..h...F..ls...............l.p..Dts.....G........................tlQlhhhs.............................................tthhp.h.t.p..p..lp..........ts..s.h.lt......lp...Gpl.ppp.............pts...............................lplhspp...lp.....................................................	0	2125	3961	5336
+932	PF01841	Transglut_core		Transglutaminase-like superfamily	Bateman A	anon	[1]	Family	This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase, the human blood clotting factor XIIIa' [1]. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase [2], it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease. [3]	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.81	0.71	-3.86	87	6914	2012-10-10 12:56:15	2003-04-07 12:59:11	14	194	2577	45	2597	6853	1021	111.30	20	20.05	CHANGED	pphuppl......tstpssh..ptsptlhpalp.......pphpYs............hssssts........stphLt......spp.....G.pCtpaAslhsshhRuhGI.PARhlsGhhh.......s........................................sts.ss....................HuWsE....sah................shu.....WlshDs	....................................................................h...................s.h.....pth.h.t.lhphlt...............pp.h.pYs.........................t.s...sps......................stpsLt........ppp...........G...sC.psaAtlh.hs.hh.R.s.h.Gl...P...A...R..h.V.s.Gahh.............s...............................................................t....sh.....................................................................HuWs-l.ah................................s.ts......WhhhDs...................................................................................................................	0	827	1630	2120
+933	PF00927	Transglut_C	1005; Transglutamin_C; 	Transglutaminase family, C-terminal ig like domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1005 (release 3.0)	Domain	\N	26.60	26.60	26.60	26.70	26.50	26.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.28	0.72	-4.01	41	1042	2012-10-03 16:25:20	2003-04-07 12:59:11	17	15	108	79	564	1010	0	100.00	19	25.81	CHANGED	sphplclhssss.hupchsltlphpNshspshpsh....sshslphsGlhh..ptppcphthsltPtpptphplphh.pchG..pphlsp...hppspltcVpuhtplhlpp	...........................thplcl..s.s.sh.lGpchslplphpN............shsps.ps.....sshslphs.........Glhh..phhp...........pthhssltPtpptphph...plhspch...pphlsp...hp.sth.t.plpshtplhh............................	0	94	147	303
+934	PF02779	Transket_pyr	transketolaseD2; transket_pyr; 	Transketolase, pyrimidine binding domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.96	0.71	-4.78	93	20295	2012-10-02 16:07:47	2003-04-07 12:59:11	19	58	5038	173	5571	15647	10577	175.70	23	29.45	CHANGED	pthshppu.spAlsplhpcs.pllshutDls................sushsttpuhhp.p.......................RhhcsslsEpuhsuhssGhAhpG...hhsatupFhsFss......hspstlp.htuhtphsss.lss+sshGhGtcGPsHpuhc.huhhpslPs........................hpVhtPssss-stthlptAlp....tt.tPshlhhs+p.ht.t	.....................................................t..hshppu..spu.l......sph......h......p......p..s......s........p......l......hs..hutDlu...................su..s.h..t...t...p...p...u...h.tt...p........................................Rhh..cs.sluEtu....h..s.u...h..us.GhA..hp........G..............hhsht.upF.hs.F..hp.............hsps.t.l.t......h....t........u.h...h....p..h....s..ss....lhs+...s.s.h.u.h...G..t...c....G..s...s.H...pu.h..........p...huh..l..pt.h..P..s.......................................................................................hpVh..tPu...sss..-stthlpt...........ul.....p.....................p..s......P..s.hlhhs+p.h.....................................................................................	0	1847	3551	4709
+935	PF02780	Transketolase_C	transketolaseD3; transketolase_C;	Transketolase, C-terminal domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2].	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.45	0.71	-4.19	80	17209	2009-09-13 15:57:48	2003-04-07 12:59:11	15	48	4995	153	4660	13131	6413	117.50	22	22.65	CHANGED	Gcuplh...+pGp-lslluhGshlphulpAAcpLtpp.....GlsscVlDhRolpPlDhcsl...hptsc..+ss+ll..lVcEuhh.huGhuutlsshlsc.psht.h.sslhplss...-sshshs...thththhshs..ppl	........................s.h.....ppu..s.-..lsllu.hG.s.h...l.ph.A.lp.AA.cpLptp.................Gh.ps.pll..ch.Rslp..P..h...D..t...-.h...l...hp.t.c...cs.t..+.h.l.........llp.-....s....s...h...p..s....u.....l...u.....u.....tl.st.hh.........t....c..........sh....t.............h.........h...s...........l..t..p...h....uh.....s.s..hs.........hht.hshs.tt...................................................................	0	1573	3034	3963
+936	PF00335	Tetraspannin	transmembrane4; 	Tetraspanin family	Bateman A, Finn RD	anon	Bateman A & Pfam-B_3109 (Release 7.5)	Family	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.90	0.70	-5.07	212	4340	2012-10-02 01:14:40	2003-04-07 12:59:11	15	37	310	4	2488	3981	12	207.50	17	82.23	CHANGED	hlKhh....lh.hhN..hlhhlsG.hsllu......hGlhh...........................................tthhhs..s........hhllh.lGsll.hll.uhhGs.hG.uh.......+csp..........shLhhahh.hlhllhlhplssulhshshpsphpsthtp.h........................................................................tthppssshppthstlp...pphp.C.CGhpshp-atp.......................................................................................................sstssssshhppGChptlt...phlp.pp..hhhl......sslulsl....s.hlplluhlhuhh.Ltpph	....................................................................................phh.....hh.hhN..hlh..h........lhG...hhllu...hGlah....h.......................................................................t................h..h.h..s.s..h...lllh..h.Gslh.hll..uhhGs..hG..uh....................pc.sp......................shL...hh...........ahh....hlh..l..l.h......l..h.....p.l.s..s.u.lh.s..h...h...h..p...s..p.hppthtp.h...................................................................................tht...p..p..t.t..h..p.ph...hshlQ...............pphp..C....CG..h....p....s.....p..Da......t..........................................................................................................................................................................................................................................................................t..t.......t..t..t.t.....h....h..p..p...G.Chtt.l...........phhp...pp....hhhl..............shhshsl...h.h..h..p....l..hshhhuhh.h....h......................................................................................................................................................	0	761	1047	1771
+937	PF00905	Transpeptidase		Penicillin binding protein transpeptidase domain	Bateman A, Finn RD	anon	Bateman A & Pfam-B_726 (Release 8.0)	Domain	The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.70	0.70	-5.40	42	25088	2012-10-02 21:13:33	2003-04-07 12:59:11	17	55	4539	218	4622	19829	10300	286.30	21	43.58	CHANGED	ussVlh-s+oGplLuhsspsphsspp...........................hhtt.apPGSThKshss.hhul-sGhhpsppthpt.st.h..sstshpsapps........hshppuhppSsNhhh.pl.shclGtc..................p..htphhpphGhGspss.sh.tp..t...............................................hstsssuaGpu.lsloPlp.sphhsslsssG.h....hht........................t.....chshstpshpplpphhttsspss..................shpluuKTGTAphht.ts.h.............huhalGa.s.tsssphshslhls.......tssttsutssstlhpplhp	........................................................................................shlsh-spoGpllAhsu.s...s.a.ssst......................................................................................h..N.p.s.......h.......p......s.......h.......h........p....PGSohKshsh...ss..A..........l..........-..........p.........G............h................h...........s..............s.......s..........s..............h.............h............s.............s.........s..........s..............h.........h....................h............s.........s..........t.......p......h.......p.......s....astp...........................htG......l.s....hpp.......A....lt....p..S..sN....s....s....hs...p.l....s....t....p..l....G.h..s.......................................p......h.t.p.h.h....p.c.......h.G...h...s........p.......t....s...t..................................................................................................................................................................................................phhs.h.u.h....G....t.........G........h...sso......P..l.phup.sauslAN........s.Ghh.h..........p.......P..p...h.l.p....p...l....t.....p.sp.h...........................................................p................s...p....p...s....h....s...p....p....s..s..t..h.....l.p.p.....h.........h....pt..Vspps............................st...th..t....h.........s...h......p......l....u...G....KTG.Tu....p........h...................................................shh..sGa...................................s...........P.....p....h.s.h.s.lhht....................t..s....t........h....................................................................................................................................................	0	1494	3005	3893
+938	PF01609	DDE_Tnp_1	Transposase_11;	Transposase DDE domain	Bateman A	anon	Pfam-B_1013 (release 4.1)	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction [3]. This family contains transposases for  IS4 Swiss:P03835 [1],  IS421 Swiss:P11901 [2], IS5377 Swiss:Q45620, IS427 [4], IS402 [5], IS1355 Swiss:O69604, IS5, which was original isolated in bacteriophage lambda [6].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.43	0.70	-4.79	91	12598	2012-10-03 01:22:09	2003-04-07 12:59:11	16	50	2656	6	2783	18569	2527	188.80	13	58.95	CHANGED	ttttphh......hlDuohlpss..........................................tth..thpstpthtuh.Khclhs.....sssshhhshtls.sush.pDtphhtp..lhct..............phthlhuDtGYsstp....hhpplppp.shph..hht....h+tstth..................................................................................................hhtpptpthth..............................hhptRhtlEpsFphlKph.hthsc..hptpshsphpshlhht.hlshhl	..................................................................................................................................................................................................................................................tt........hD...h...........................................................................................................................................................th...t......h.phhh....................tp....t.h....h..tht.h........h.....ss....ph...p..-..h..p....hh.t........llpt.................................p.t.t.h..l.h.s..D.........tu..at.s.tt.........hhp..t.l...p....p......t....t...hph..........hh......................h+.t.p.tth..................................................................................................................................................................................................................................................................................................................h....h...t.....t.....t....t.....t....................h.......................................................................................................hh.p.t.R.h.t.l..E.t..h...ap.h...+...p.......ht.h.pp......h..t.p....t..t.thp...hhhh.hhh.......................................................................................................................................................	0	850	1859	2290
+939	PF02371	Transposase_20	Transposase_19; 	Transposase IS116/IS110/IS902 family	Bateman A	anon	Pfam-B_280 (release 5.2)	Family	Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with Pfam:PF01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.69	0.72	-3.88	139	6999	2012-10-03 02:11:09	2003-04-07 12:59:11	11	25	2087	0	1815	6255	787	83.60	27	26.97	CHANGED	sphLtolPGlG.lsAssllupl.s-h.pp.FpsscplsuasGLsPttppSGsptp.ps+lo+.tGsptlRphLhhuA.hssh.ph.......s..shhpthap	............................hltolPGl..G....h.sA.ssllu..........pl..u-h..pp..Fp.sscp..lsua.s.........GL.sPtp.h.pSG..sppt...ttphoK..tG.sptLRphLh..sA..hssh...ph.............p....................................................	0	542	1135	1449
+940	PF01526	DDE_Tnp_Tn3	Transposase_7;	Tn3 transposase DDE domain	Bateman A	anon	Pfam-B_885 (release 4.0)	Domain	This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli.  The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases [2].	20.70	20.70	20.70	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.91	0.70	-5.86	50	1929	2009-09-11 04:42:20	2003-04-07 12:59:11	12	14	851	0	316	1636	192	297.90	33	44.98	CHANGED	DlLh-VsphTuFsptFpclpst.....chpsttptllAsllA.GsNlGlpchAct.ssslohcpLshspppalct-slppApspllstppplsluphW..G...s.Gp...s..u...SSDGp+assstpsltu.phss+Yt...stGlshYsalu-passhauplIssstpEAhallDGLLppp..os.l...pscp..hh..sDTtGho-hlFulhcLLGapFsPRl+slp...c..p...+Laph...c..s..ss.pYsplssl.h..tp....pIshclIcppW--llRlssSl+tGplsuotll++Luuh.s+pssLtpAlpElGRl.+TlFlLcYls..-.slRRplpttLN+uEuhpsLsRAla.aGptGclps+sh-pQphpssuLsLlsNuIlhWNThalpcslpplcpp.G..pls.s...chltclSPlsapHINhhGcY	.........................-llhtlst.s.tF.pthhthptt........t.t....lhsslh.u.uhNhGhp.hsp......ssh.shtpLt.htt.hhp..cshptA.s...lhph..ph....hsthW..G...t.up...hu...ouDG..ph.s.....ps...s.t.s.+Yh.....t........GhhhYphlscp.assh....s...................hlsss.p-uhall-Gll.p..p.....os...l...p.pp..hhsDTtG..................hochsFuhhtLLGaphsPRltshtp...p...phah......p..t........st..th..t.lt.h..h....tt....plsh.phIttpas-hhRlssSlp.Gpsssshhl++Lss..sptstlh.AlhEhGRl.+TlahLcalp...s.phRRplpttLN+GEuhpultRslh.as.ph.Gc.lpp+thcpQp.phssLsLlssullh.WNThhhppshpthp.....tp.G...hs.t.phlttlSPltapHI.NhhGcY..............................	0	61	182	248
+941	PF01548	DEDD_Tnp_IS110	Transposase_9;	Transposase	Bashton M, Bateman A	anon	Pfam-B_646 (release 4.0)	Family	Transposase proteins are necessary for efficient DNA transposition.  This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and members of the IS111A/IS1328/IS1533 family of transposases.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.69	0.71	-4.53	127	7132	2009-09-14 00:11:16	2003-04-07 12:59:11	12	28	2092	0	1856	6395	788	129.20	22	42.24	CHANGED	hlGlDluKpphpls....hhssss............htptphsss.tuh.pplhshlpph...t..............hhlshEusu.htt.hltphLpp.tGhpVhllsstps+shtp....ptsKoDthDAphlAchspp..t...php....h.......htstptppLptLsptRcpLhpppsphpNc	.............................................lGlDlu.K.p.phpss....hhstps..........hh.h.p.t.p.h.s.s.s....ts...h....pplh.phltph..t...................hhls.hEusuhht.....h.......h......h......p......h......L......p.p....h........G......h......p......l..hl..l.s.Pthh+tht............ptsKoDthD...Ath.l..A..chhpp.........t.....php........h.......h.st.t..ptlpt.Lh....p....h....+p.plhpphst.hs..................................................	0	549	1162	1475
+942	PF00579	tRNA-synt_1b		tRNA synthetases class I (W and Y)	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.88	0.70	-5.29	40	11971	2012-10-02 18:00:56	2003-04-07 12:59:11	20	46	5006	203	3414	8921	6461	279.10	24	74.98	CHANGED	pp.tt.hplhsGhcPTus.lHlG.ahsslpphhphQ......tGacshhlluDhpAhhscss.....cplhpppphhtss......L.uph.lDsp+...............sp...lhhpSchhpph..phthhlpplushhpls+Mhphcs......hppchpp..............slshuthsYPlLQuhDhhhhpsc....l..sGsDQptplphuc-lsc+hspp...................hshslhss....llstssGp..KMSKStss...sIaLscptpsshchhpphhssscp..tltthhthhshlss..............lphhpth...ttpss......pthcclhsphhsthhpsschtptstpshpphhp	.....................................................................hp......tlhsG..hcP.T.us..LHlG.alssl.hp.h.....h.p.h.Q....................ss...a..c..s..h.......h..h..l...u...s.....h...puh.hsc.s.......cp.l...p..p.p.p.t...htss................l...uth....l..D......pc.........................................................................................sp.....lh....p..u.c...h....t.ph.......phh.h.h..l..p..s.hsp..h..hpls+M.hphcs..................h..tpchpp.........................tsl.s.h.s.F..sYPl....LQ..uh.....D.hh.....h..h..pss........................l..sGpDQh.tplphu..p-.....l.s.c...+.h.stt..............................................................................s...t.sl..hss.................ll.st...h......D.........G...............s......................KMS.K.St..ss................slhL.........s.p.........p..sshc.h.h.p..t.hhsss-t.........lh.h......hp.h..h...s......hs.............................................l.p...h...h.p.th......stps............hpc.lhs..p.h..s..t....h.....htstchtptstchhpthh......................................................................................................................	0	1164	2149	2869
+943	PF01409	tRNA-synt_2d		tRNA synthetases class II core domain (F)	Howe K	anon	swissprot	Domain	Other tRNA synthetase sub-families are too dissimilar to be included.  This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.61	0.70	-5.18	46	6642	2012-10-02 14:22:40	2003-04-07 12:59:11	15	27	5187	59	1844	6318	4237	222.30	45	68.66	CHANGED	slDlolP...upthtsGshHPlspsh-clpclFhthGFphhp.GsplEs-aaNF-ALNlPppHPAR-hpDTFal....p....................................s.phlLRTHTosVphRth.....pppc...sPl+llu.G+VaRpDs..DATHps.FHQlEGlllDc..slohucLKGsLcpFhpphFGtc.hclRFRPoaFPFTEPSsElDl.t.................tcpstWlElhGsGMl+PpVLcss.......Gls...pchsGhAaGlGlERlAML+YGlsDlRphaps..Dl+FLcpa	.......................................................................................................................................................................t.lDlohs.....sp..h.t...GthHPlsth.hcclpp...hF...h...t........h........G........a........plhp....G....s-lE..s............-aaNF-.sLN...hP.t.p.H.PA...Rs.h..p...D.TFYl............................................................................spphLLR..T..aT..S.s....V...Q...h...Rsh..................................ct...pp.......sP...l.+....h.IuP.G+V.YR...p.Ds...D...u...TH...os...FH........Q..l..EG....L...l...l.............D..c...................s..l........o...h.............u...c...L....K....G..s..L..c..t....hh+ph....F.........G.......p..........c....hp............lRh........R.P...SY.F...P....F.T.E.PSsElDlts..........................................t.ctssW.lE...l.LG.s.GMV+P.p.VL.c...s...........................GlD..sp.asGFA...FG.....hGh-RhsMl............+aslsDlR.haps..DlRFhpp.................................................................................................	2	623	1139	1548
+944	PF01588	tRNA_bind		Putative tRNA binding domain	Bashton M, Bateman A	anon	Pfam-B_482 (release 4.1)	Domain	This domain is found in prokaryotic methionyl-tRNA synthetases,  prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding  protein (G4p1 or p42, ARC1) [2], human tyrosyl-tRNA synthetase [1], and endothelial-monocyte activating polypeptide II.  G4p1 binds specifically to tRNA form a complex with methionyl-tRNA  synthetases [2]. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme [2]. This domain may perform a common function in tRNA aminoacylation [1].	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.02	0.72	-4.15	43	10729	2012-10-03 20:18:02	2003-04-07 12:59:11	15	48	4863	53	2411	7871	3721	99.10	31	16.79	CHANGED	l+VGcllcsEcaPsADK.LhhhplDlGpcp.....RplVuGlsphhs..-th.s+hlllls.NLcPt..............KhRGlpSpGMlluAp.......sssp..htllssstss.sGsc	..............................................lhVGcll..ps..c..p..h.P..s.......u..DK......Lhhhpl.......D....l............G.......s..........c.........p...............hpI.Vs.Ghs.shhs..........cs....l...luphss.hls....N....hp.p..........................Kl.R....G..h....SpG.Mlhuspp...............sspp....s..l.l.ph.s..p.s.h..sGt..................................	0	822	1535	2024
+945	PF03250	Tropomodulin		Tropomodulin	Bateman A	anon	Pfam-B_3359 (release 6.5)	Family	Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments [1]. Limited proteolysis shows this protein is composed of two domains [2]. The amino terminal domain contains the tropomyosin binding function [2].	21.80	21.80	21.80	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.67	0.71	-4.68	12	463	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	101	0	230	395	0	130.10	40	31.99	CHANGED	Mu.s...hp+-LtcY+DlDEDElLtsLStEELcQL-htLpElDPENshLPAGhRQ+DQTpKsPTGPaDR-pLLcaLEKpAlEhKDR-DhVPF.TGEK+GKlFVPKp+stch..tcEploL-.P.ELEEALssATDsElCDlAAILGMaTLhssp	.....................ap+cLpc.Yc.D.lD.EDElLusLSsEELcpL-pEL--lDP-s..shLPsGhRQ+sQTpKsPTGsFsR-tLlpal..E.Kp.A....hchh.-+E-h..VPh....st.h.+.G.+....a..h.......................................t..................t.......h..tl-.....s.-.hcp..uLtpAspt-hh-lA.tlls................................................................................	0	29	46	105
+946	PF00992	Troponin		Troponin	Finn RD, Bateman A	anon	Pfam-B_62 (release 3.0)	Family	Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I.  Troponin I binds to actin and troponin T binds to tropomyosin.	23.20	23.20	23.30	24.10	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-11.04	0.71	-4.09	56	1116	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	175	22	337	1073	1	125.00	33	53.51	CHANGED	K+pLKsLhhtpAtpcLcpEpcc+tpE+pphLp-+s.shp.hsu..sps-LQcl.s+ch+p+lspl-EERYDhEt+lsKpctEI--LphKl................hDL+GKFKKPsL++V+hossuhh+uhLGsKHpsshDLRusLKpVK	...................Kp..K.sLh.hpAh.-hchEpccKEEEc............hhhLp-.Rltthc......h...........ppu-...................Q..........cl.scc.+c+.s+l-..EE+h.chE.tc.t+pctE....cthppKs..........................t-h+t...hK+..sh+.ch+hph.u.h+t.Ls....c...+.h..s.p.pLRt...phKplh........................................................................	1	71	116	229
+947	PF00234	Tryp_alpha_amyl	tryp_alpha_amyl; 	Protease inhibitor/seed storage/LTP family	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This family is composed of trypsin-alpha amylase inhibitors, seed  storage proteins and lipid transfer proteins from plants.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.26	0.72	-11.45	0.72	-3.77	187	1632	2012-10-01 19:46:35	2003-04-07 12:59:11	17	6	243	52	214	4676	6	103.10	21	68.27	CHANGED	Cstshhp..............................lssChshhps..........spppCCstlpsl...................ttttChCtslpshhhs................................................................................tht..tsttLPshCsl....shP.........tC	..................................................................................hht........................................h....s..hshhp..t.t.hs................sl.ps.CCppLtsl....................sphCpC..tsltshhpuh..............................................................................................................................tt.ls..hh.sAs..slPuhCs.l..sls..........................................................................	0	29	95	159
+948	PF00089	Trypsin	trypsin;	Trypsin	Lutfiyya LL, Sonnhammer ELL	anon	SCOP and Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.76	0.70	-4.76	71	22248	2012-10-02 13:45:52	2003-04-07 12:59:11	21	596	2517	2044	9786	28849	4196	206.20	23	59.84	CHANGED	IlGGppsphtsh....Pa.sslphps...........hCGGsLlspp..all.TAuHChps..................phpl.....hhGt..thppppss......phhplpp..hhhp.tassps..............tDlALl+Lpps........hphssslpslsLss.....ss...tssspshlsGaGp...stpsu........sphLppsplsllspp.pCpp....h..................lssshlCsss........tt..ssCpGDSGGPllstst........lhGlsS....aG..hsCupsph....sula.spls....thhsWI	..........................................................................................................................................u.....s.....t.ph....Pa...s..t..l.......htt...................................hhC..G...G...s...l.......l........s..........p..........p.......a......l...L..T........A..A...H.C.hts......................................tthpl................hhG....t.............t....h....p....t......t......p.s.......................t...h..h..t..lpp.............hhh..H.....p....a.s..t...ts..h............................................tpD..l......A..L.l...c...L...pp.s..................................h.t....h...s...p....t....l...p.......s.....l..sLsp.....................t.t...........s...s.....p....t........s.......h......l....s...G..W..Gp.................s.t.tss..........................sp.hL...p..p...s..............p.l.......l.....l....s....p...p....t...Cpp............h.....................................................lp.p.s....h..lCuuh.............t................t...ts....s...C.................p..............G....D........S...........G....G.P...L....h...sptt...............................lhG.l..s..S.............aG........s....C.....s....t....h.................ula......splt......hh.Wl...................................................................................................................................................................................................	1	2699	3841	6981
+949	PF02210	Laminin_G_2	TSPN; TSP_N;	Laminin G domain	Finn RD	anon	Pfam-B_4211 (release 12.0) 	Domain	This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.64	0.71	-4.10	208	7915	2012-10-02 19:29:29	2003-04-07 12:59:11	19	1063	156	84	4277	8885	448	128.10	19	16.04	CHANGED	F+T...p.pssGlLlassstss...................taltlplp.sGp.lthphshu................tss.hhhhsspp..........l.sDGp.WHp..Vplppptpp................hplt.....VDsptstttttsttt...................................thphsss.lalGGh.spt.t................ppsFpGClpslplssp	......................................................F+T..tpss...G.lLlhssstps...............................talt.lp.l..........p..s......Gp....lt...hp.h.shu..................................ssshh.h.h.h.s...s.t.t......................l...s..D..G.p..WH..p.....Vp.l..p.....p...p..s.pp...........................................spLp..........V.D..s..pt...s...t..t...thts..ttt....................................................................tl.s.hpss...lalG............Gh..sp.t.........................................tpsFt.GClpslhhss.....................................................................................	0	870	1227	2700
+950	PF03133	TTL		Tubulin-tyrosine ligase family	Bateman A	anon	Pfam-B_682 (release 6.5)	Family	Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL) [2]. The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness [3]. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis [4].  Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent  dioxygenase domain [6].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.88	0.70	-5.49	21	2286	2012-10-10 13:17:02	2003-04-07 12:59:11	10	53	310	4	1558	2259	173	263.90	24	44.99	CHANGED	hphpp......tptlNaaPsshplspKD.hhhpslpc.tpphthc.......................hthhspoahlst-hsphhphapcppt............shWIlKPsupu+GpGIhlhschspl.............................................pppshllQ+YIc+PLLlss......pKFDlRhYVLlosh.pPLplYlYc-u.lhRFuopcYs........hsshpshhhHLTNhulpKc.t.....tpc.pthpspcaoltshhthhpp..hstcplhpplhshlhcshlsu.......hpsst.shppthssFElaGhDlhl........DpslcPWLlElNhSPsh.psssthssplpstllpslls.....lsssptpsh	................................................................................................hht............hsph..t...........l.spKt...hhhp..h.tp.h..t..h..p......................................................thhP..o.a....h.......s.....t.....c...h..t...............h..h...p........h.t..pttt......................................................................thWIh...KPs.s.....t...sp.G...p.G.........I..h..l..h...p.p.h..p.p.l..................................................................................................................ttpth.....ll....Q....cYI....pp.P.hL.lts.............................hKFD.l.RhY.lL.l..........s.....u.........h......p..P....L.p............la.h.a.........ccu.hsR........Fusp......Ys.......................ps..hp.s...hhh....HLT....N.hul.p+p.............................t..........t...................t............s.........p...p...h.s.....h.....p....p......h..........t......h.hpp.............h..p.....h.....p.....p.....h..h..p.p.....l....h....p..hhhp...hhlts...............................hpss.........h..............t...........p...s..F.ElhG......hDh.hl......................Dp.p.....h...c.....P.aL.lE..............l.N..hs.....Ps.h...t.t...s...s.....h...p.....h.p.l.h..thh.tshhp..............th................................................................	0	771	931	1276
+951	PF01167	Tub		Tub family	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.70	21.00	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-5.39	11	847	2012-10-02 20:44:47	2003-04-07 12:59:11	13	23	166	7	509	787	14	217.80	36	43.04	CHANGED	PAPpsshlpChIpRDKpGhD+GLaPsYahaL-p...EsG..hFLLAuRKRK+SpToNYlIShDPsclSRsussYlGKlRSNhLGTKFTlaDsGsssp+..sp................ospssshR.-LAsVsYEsNVLGa+GPR+MolIhPGhssssp.....RVssp...........................................Phs.sp-slLschpppst-slllL+NKsPpWs--sQsYsLNF+GRVTpASVKNFQllcs....................................scPDaIVLQFGRVucDhFTMDaRYPLsAhQAFAIsLSSFD	...........................................................................................................................pt....hpChlpR..s+p..s.........s.hh....h..a......h........h............cps.........hFLLuu.++h.++........s.t.p....spYlI.....Sh....s....s..s...s..h........S+....tu.........p...s..........a.......lGKl.R........S.N.h..hGTcFhlaDst.s.tt..t..........................................................p....s..th.p..plutl.Y.c.h..Nl.L...s.......+.G...P..R+.Mp..shh....s.hs.pt............h..hp....................................................................................................s....tt......t......s....h...t.....p..h.p..p.....p....s..hp.......phl....LpNKsPhWs-phQ..sasLNF.+........G..R...V......T.....ASVKNFQl.lts..........................................................................................................................................................s-..-.h....l.lh...QFG+l..u.............c..D.hFThDa....p.YP.lsAhQAFAIsLoSF-.............................................................................................	0	172	275	391
+952	PF03953	Tubulin_C	tubulin_C; 	Tubulin C-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.47	0.71	-4.09	66	8994	2012-10-03 12:11:42	2003-04-07 12:59:11	12	31	3147	105	2212	7432	55	113.00	52	32.23	CHANGED	PRlHFhhsuaAPLsups.....ptsacphoV.-lTpphF-spNhMs...ssDP+p........G+Ylosss.laRGcVss+-Vccsltplps+ps..spFV-WhPsulKsulsshsPhshptu........ushluNoTuIpclFpRlsc	...............................................PRLHFhhsGaAPLoScu....................uppa.Ru.loVs.E..LTp.Qh..................F.-...........s+.N.MMs.....us...D..PR.+..........G+Y....losss....ha....RG.......c...hs............K.-V.cc..p.h.hs..lps.........K.p.o.......s.F.V-.Wh.P.s.s..hK..........suls.....PPp...sl.hu..................sshluNo..TuItE..hapRls.c...................................	0	760	1134	1715
+953	PF00567	TUDOR		Tudor domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.37	0.71	-4.28	48	3295	2012-10-02 16:56:36	2003-04-07 12:59:11	19	92	277	31	2089	3372	6	118.30	19	26.42	CHANGED	hhhspthslhloplt.ssspFal.......tpstpplppltpplpphhpphtt.......ht.sthspsssshhstDs..pWaRApl.......tthsspphcVhalDYGspph.lshsclptls.pphtt........Ph.uhcspLss	..........................................................................h......pshlst.l...s...s..s...p..hah....................h.pp.t.pp....l....p.....p..........l.....p.p.l.p..p....hh.ppttt...................ht...p..h.sp.h.s.h....s...t.......h.....p....t......-.s.............pW.a.Ruhl....................t.hss.....p..p............s..pV....halD.a.Gspp......h...l...s...h......s...p......l......p..........l....s...p...p.hhp.....l...Ph.AhpspLt.....................................................	0	629	828	1457
+954	PF04906	Tweety		Tweety	Finn RD	anon	Pfam-B_5713 (release 7.6)	Family	The tweety (tty) gene has not been characterised at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in [1].	29.70	29.70	30.00	32.60	29.50	29.60	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.42	0.70	-6.06	14	332	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	97	0	157	301	0	341.60	35	69.90	CHANGED	applsusFpPcDt.sYQQSLlhLusluussLuLsLLhLhhYLlphCCsR+.pcspssp....csCClsWssllssLlC...........CAuIGlGFYGNuETsDGlhploYSLcpAN+TluGIcshVpsosssLppslcppLtpL--laus+s-.......alpslphhQp.sssllpphsulP..hWpts....slslsplAppsshhEaYRWLuYLhLLlLDLlICLlsllGLARpS+slLlshsshGlLsLllSWuShGL-hAsAVGsSDFCssPDsallp.sppphs..sDllpYYLhCu.utsNPFQQpLohup+uLssMQpplpsLL+.Als.FPsuc..csLlulQtlLNooEhsLHQLTALlDCRuLHhDYlpALpGlCYDGlEGLlaLsLFShluAlhFoshVCusP+sWphhtsR-cDh--hp-psPh	....................................................................................................................................................................................................................................t.p...h.puLh.hlus.l..uhh.sLsl.s.Llhlh...hYh...hhhC...Cp+p..p...ttpt....................tssChshs.h..l..hssLl.s...........s.sul...u..l..GFYGNuEss.DGl.plh.ulh....psNpTl.....s.slpp.......hl.ts.sttLp...ps.lc...tpLtpLpc...h..h...stp..s-............hltshphhpt.hpslhttht..sls.....hhpts......shs.h.tpl.....up.psshh-.......Y.R....Wl..ua.lhLL.l.ltll.....lCLh.s.llGl...........s........+...........pS+hhll...hhsh..hu...lL..sLl.lSWsuhGlc.hAsuV...uhSDFCssPDsalhphsppphs.......s-llp.YYhh.Cs.....s..hs.....N...P.F.Q.Q.p..Lo..sp.+...uLsph...ptplt.tL....p...uh........ass.sp.......csLhtlpthL..N....soEh......shpp.LsAl...l....cC...RuLHtDYh.pAlp.GlC.DulpGL.laL....h..L.aS...hlsAhhhsshlCshs..+sWt.h......p.p.p.tp........................................................................	0	39	56	101
+955	PF04564	U-box		U-box domain	Bateman A	anon	Pfam-B_2801 (release 7.5)	Domain	This domain is related to the Ring finger Pfam:PF00097 but lacks the zinc binding residues [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.36	0.72	-4.01	16	2544	2012-10-03 15:03:13	2003-04-07 12:59:11	10	170	360	21	1743	2959	196	70.60	32	11.07	CHANGED	lPDEFhDPIhhpLMpDPVlLPSG.hshDRusIp+HLhs......spoDPFs.RpsLTpcpLhPNhpLKpcIspalpp+cp	...........................hPpt.F......h..C....PIo.hcl......MpDP.V.l.......h...s...o.....G....hTY-..Rps.I.p.c.a.l.p.p................................s.p.osP.h....T...p.......p...........s..L...s..p.....p.........p..L....h.PN.hsL...+phIppahtpp..h................................	0	505	1047	1434
+956	PF00627	UBA		UBA/TS-N domain	Bateman A	anon	Bateman A	Domain	This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle [1]. This domain is found at the N terminus of EF-TS hence the name TS-N.  The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU [2]. The domain has been found in non EF-TS proteins such as alpha-NAC Swiss:P70670 and MJ0280 Swiss:Q57728 [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.47	0.72	-4.00	141	9566	2012-10-01 23:03:33	2003-04-07 12:59:11	26	206	4854	104	4154	7764	1831	37.30	34	8.50	CHANGED	hspptlppLhph..G...aspp.pspcAL.ptsss..sh-pAhphL	...............stphlcpLp-h...G....hshh.cs++AL..p.....p..ssG...cl-tAl-hL.............	0	1308	2242	3222
+957	PF01040	UbiA	CytC_assmbly_fac; COX10_ctaB_cyoE;	UbiA prenyltransferase family	Finn RD, Bateman A	anon	Pfam-B_1357 (release 3.0)	Family	\N	24.60	24.60	24.60	24.60	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.17	0.70	-5.17	138	10787	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	4280	0	3435	8227	6621	264.00	17	84.83	CHANGED	hhhsh...hssh..hu..hhhshtshhsh.........hhhhhhhshl............hhts.us.hh...N-..hhDhchDt.................tt..tp..........ls.sGtls....p.pshh.hshshhhlu..lh.....hu.............hhhs.hhhhhhshh..shhh..s.hhYo....................hh+phshhsplhhuls...hu......hhhh..hushh......hsth...............................sh.hhlhshh.hhhshslhht........thtDhcsD.ppsGhpo...........lshhh........t.thhh.......hhhhhsshhh...............hhhhhhhhhhhhhshhhhshslhh..h.h...........h.........................hhthhhhhhh	........................................................................h....hhssh.hu.......hhhu...t.s...h..sh...............hhh..hhhhlush.............lhtu.uussh...............Nc....hhD.t.chDtpht................................Rp..tpR..............s........ls..sGtlo...........p...puh...h...hshh.h.hl..lu....hh.....lh.................................hhhs...h...h...s...h....h......l......u.hh.....ulhh.....h..hhYo...........................hhK.+.hs.....h.....splh.suhs..........hu..........hssl..hGhss.........sssph......................................................shhhhl.hhhh.h.h..h....h....s....huhhhh....................................sht-.hcs.D.....tp....s...G.hto................lslhh...........Gtptshh...........................hhhhhhhhhhh...........................................................hh..h.h.hhh..h..s..h...h..h.h..h..h..s..h..h.h.....h.sh.h...h..h...h.......h...h...h...h..........p.....................................hhhhhhhhh..........................................................................................................	0	1089	2178	2911
+958	PF00240	ubiquitin		Ubiquitin family	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.96	0.72	-4.58	76	11560	2012-10-03 10:59:06	2003-04-07 12:59:11	18	265	901	508	6203	11456	369	67.10	44	28.05	CHANGED	+shssp........phslclp.ssolpplKpclpppps...lssspQ+LlasG+.L..cDppslt-aslppss..slplshc.p	.........................................+olsGK......slsl..-.V.-..s.o.D........T..l....c.sl.K..s....K...I........p..-..+cG.............IP.......P..-.......Q.Q...RL...I........F.....u........G......K......p.....L......-D..........s...........+......T..L.....u.....D....Y.....s...Ip.....cpo......TLHLVl+...................................	0	2304	3483	4906
+959	PF00789	UBX		UBX domain	SMART, Mistry J, Wood V	anon	Alignment kindly provided by SMART	Domain	This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.56	0.72	-3.92	22	2190	2012-10-03 10:59:06	2003-04-07 12:59:11	15	58	327	23	1473	2158	19	82.40	21	19.37	CHANGED	spstsssplplRhPDGp+htc+F..pscslpplhpalpspt.sts....p.........................FpLhsshP..R+.hspps..poLp-s.thhssuslllph	................................................p....stsplplRh.s...s...G...p...p..l.p.p..c.Fp..sscsl..p....s.lh.p.al...p...s...p...t....s...st.....t.............................................................................F...p...L....h.s..s.a.P.....p+.......h........s....p.p..s............t......oLp..-h...hh.ss.u.slh...h.................................................................	0	463	739	1131
+960	PF00443	UCH	UCH-2;	Ubiquitin carboxyl-terminal hydrolase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null --hand HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-12.07	0.70	-5.28	53	8903	2012-10-10 12:56:15	2003-04-07 12:59:11	24	248	429	43	5798	8963	637	380.20	19	45.37	CHANGED	hsGLtNhGNTCYhNSlLQsLht..ssthp.chlh..............................................p...............stpst.ttts..........................................................................................................................................................lspthpplhpphhps......................pppsltPpt.............................................................................................hhptlsthtpp..hp.......shpQpDApEahthLL-pLccshpt..t.....................................................................................tt.shl..pclFpGphpsplpChpCsppspshcshhslplslttppph....................................................................................................................................................................................................................................................................................................................................................................................................................phhphpttpthptppphhsspspppppuhKphplpcLPp.lLhlpLcRF......aph.ptth...ppKlspplpaP.....h.pLDls....shhttstt.................................................................................................................................................................................................................................................................................................................................................................hpYcLhuVlsHtG.s.......hpsGHYhuahhp.........ps..............................ptt.......WhpacDspVsphs................ppl.hp.............................psAYlLFY	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hGL.N..h..G..N.T........C.ahNuh......l..Q..............s........Lh.t...h....hp...phhh...............................................................................................................................................................p.....................................tt......t....t..t.t............................................................................................................................................................................................................................................................................................................................................lhpth.t.p.l...h.tt.h.ps.....................................................................t.t.p.s.h..s..P...p..t.........................................................................................................................................................................................................................................................................h...h...p...t....l.....t...t.h.t..p.......ht.........................shp..Q.p.......D.......u........p........E.......h.h.............t.......h..l......ls..t..l...c..p.p..hpt................................................................................................................................................................................................................................................................................................................t...t.t..p...s.hl..........pp..h.F.....t...G.....p.....h...p.......s........p.......l...p.....C.......p...Ctphstp.pshh.lpl.h..ttt...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.httttthhstpspthtpsp+phpl.t.ph....P.......l.L................h.l.......p.......L.......p......R..F..........................hp.....t............................htK....l.sp.h..l.p.aP.....................t.Lc.hs...............hh..t...p...t......t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhY.p..L.h..u.V......l....s...H................G....s..................h.p...s.G...H.....Y..h......sa..hpp.......................tt...................................................................................................................................................ptt..............Whh...as..D....pp..V..p...h.p..............................ppl..p...............................................tpuY...hLhY.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2079	3020	4452
+961	PF03456	uDENN		uDENN domain	Callebaut I	anon	Callebaut I	Domain	This region is always found associated with Pfam:PF02141. It is predicted to form an all beta domain [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.27	0.72	-4.00	45	1381	2009-01-15 18:05:59	2003-04-07 12:59:11	13	72	202	2	776	1312	4	65.10	30	5.71	CHANGED	pPcllppaPp....p.........pcp.h.pslshFCFPpGlshhspp........psphFsFlLTctDGs+h.aGhChphh	................splltpaPpps........................ps....h...pslshFChPpG.h.ph...ts.s......................tsphasFVLTs.t..........D.u..s.+p.a.GhChphh.....................................	0	186	286	501
+962	PF03167	UDG		Uracil DNA glycosylase superfamily	Aravind L	anon	Aravind L	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.75	164	10115	2009-01-15 18:05:59	2003-04-07 12:59:11	14	32	4976	114	2700	7557	3938	160.00	22	68.49	CHANGED	.shsssssc.llllGpsPGt.pp......st..sGtsFsst.........sGphLpp.hl.tph............................ulscpp...................lhlsssltp......................t..ttpssps-hpts.ps...hLhpplph.hp..Pclllhl.GptAhpthh.h...........h............................htth.lhshhHPSsh.tt.....................hp.t.h.phhp.pLp	..............................................................................h.....tss+llIlGpsPht..ss............pt........pG...hsFss..................sss.p.Lhs...hh...ppl..................................................................................uhs.cps...............................................lhlhNsl.......................................................hss.pp.s.s.p..sch..sts..pt....................tlhp..tl.sp...hp......t.........l.....l...hhL..Gph.Atpphhh..h..................................................................................sttphhll...ssHPSslstt.hth.................hsst.h.tps.t.L.........................................................................................................	0	865	1704	2249
+963	PF02809	UIM		Ubiquitin interaction motif	Aravind L	anon	Aravind L	Motif	This motif is called the ubiquitin interaction motif. One of the proteins containing this motif is a receptor for poly-ubiquitination chains for the proteasome [1]. This motif has a pattern of conservation characteristic of an alpha helix.	20.40	2.90	20.40	4.00	20.30	-999999.99	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.07	0.74	-6.49	0.74	-3.89	46	2346	2009-09-16 13:18:06	2003-04-07 12:59:11	15	72	279	15	978	2205	32	17.30	40	7.58	CHANGED	tpE-pcLphAlthShp-t	.........pE-tc.LptAlphShp-.......	0	264	430	695
+964	PF01027	Bax1-I	UPF0005;	Inhibitor of apoptosis-promoting Bax1	Bateman A	anon	Pfam-B_1376 (release 3.0) & Pfam-B_5704 (release 7.5)	Family	Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localised to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localise predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress [2]. BI-1 appears to exert its effect through an interaction with calmodulin [3]. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner [4].	26.10	26.10	26.20	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-12.10	0.71	-4.72	511	5798	2012-10-01 20:22:31	2003-04-07 12:59:11	15	12	3474	0	1486	4003	2434	202.60	25	84.39	CHANGED	pphl.ppsYshh......uhu....lh.lo.uhsuhhsh..................................h.....hhhhh.......hhhs.....luhl.h.h.s...h.tht............p.....sss........hs.hh......hhh...sasslhGhslus................lhhh.......ht................sshlspA..hh.....hTushFsuhohh...uhpo...++........D.......ho.th..GshL...h........hull..sl....lluulls.h.F......h...........ssshphsl.u....hlu....lllFs.Gh..h...haDT...p.pl....h..........p.....ththtsh.................................lhuAlsLYL.....DhlNLF...l.h...lLp...l.h	.......................................thl.ppsYhhhulsLh...ho...uhsAhhs.h.h..................................hh....hh.h.hh............hhl.st.....lshh..h.h..h.h.h...h....thp.............................................p...h.sss..........hh.......hhh...........hao...shhGhslus...................lhs.h.Yh................ssslhtA.....hs.....hTus.hFh.shohh.....uhpo...++.........................D........ho....th....GshL...h........hull....sl.......llus...llN....h...F............................lt.................ssslthsl.o.............slulllFs.Gh....l...ha.DT......p..pl.....h............p.....tht.ss..................................lhuAlsLYlDh...lNlFl....lLplh...................................	0	437	786	1139
+965	PF03684	UPF0179		Uncharacterised protein family (UPF0179)	Bateman A	anon	SWISS-PROT	Family	The function of this family is unknown, however the proteins contain two cysteine clusters that may be iron sulphur redox centres.	25.00	25.00	69.70	69.30	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.06	0.71	-4.62	24	104	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	103	0	79	109	6	141.80	37	95.34	CHANGED	hITLlGpcLA+sGsEFlahG.sscCcsC+h+psCh..NLp.G+RY+llpVRsst..pcChlH.-ssVpsVEVtcs.slhsllpo+pAhcGuplohpss.Cs..h-CpsachCpP-Glhpu-+hpIhcllGcht...C.tG.+plplVclthh	....hITLlGpcLAcsGtEFlahG.ss.cCcsC+h+phCh..NLc.G++Y+ls.sVRsst....ppCslH.-ssVpsVEVtcs.slhshlpu+tAhpGuplshpss.Cs..h-Cptac..hC..pP.-.GlhpG-+h+IhcllG-h.t..C.pG.csLphVclh.h......	1	16	46	63
+966	PF03699	UPF0182		Uncharacterised protein family (UPF0182)	Bateman A	anon	SWISS-PROT	Family	This family contains uncharacterised integral membrane proteins.	19.40	19.40	22.50	23.80	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	774	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.59	0.70	-13.39	0.70	-6.60	63	654	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	582	0	224	642	800	783.20	35	82.82	CHANGED	p+s+hhhhlhhlllhlllhsh....hsshhs-hhWFpplG....atsVFhTplhsphhlhlhs.................................................................................hllhhlhlhlslhh.sp+st..........ht..h.t......ht.....................t.hhhhhhphhhhslshllullsuhhsuup.WtplLha....lssssFGpsDPlFstDluFYlFpLPhhchlhshlhshllluhlhsllsa................hlhusht.......hsstth...tlsptsptpLulLhulhhLlhAhuaaLcpapLLao..s..pGs.hhGAuYTDlpstLPshhlLshlullsAlh..h..................hhsh.................hppph+h................shhuhslhllssllhsslhPtllQpFhVpPNEhphEpPYIccNIshTRpAa.sL-p..lc.hpsasspss..Lsst.s.....ltpspsTlsNIRLhDspPLhpTapQLQQlRsYYpFsc.lDlDRYpl.sGp........................hpQVhlusRELs.ssLstpupoWlNcHllYTHGYGhlhuPlNpl.............os-GhPpa..hlpDIPsssph..................sltl...ppPRIYaGEh.......ossYsIVs.s..pst....EaDYP...............................................................pus.pN.shspYsGsGG....l.lsshhpRllaAhphp-hplLlSsslss-S+ILapRslt-RVcclAPFLphDuDPYhVl.sc........G+................lhWIlDAYTTSspYPYSp..Ptp......................pslNYIRNSVKslVDAYsGoVsaYlh.DtpDPllpsap+lFPslF+PhuphPssLpsHlRYPpDLFplQsphlspYHh.....TDPpsFYsp-DhWplPp.....-..........................hsss.....pts...............htPYYllhpLPs........ppptEFlLh.sasPts......RsNhsAaLuARu......Du........psYG+lllaphP..+pchlhGPtQlpspIsQDspISpploLW	...................................................................................................................................................................h....hhhhh.hh.h.lhl.llhhh...hhsshasDaLWFsplG.......apuVFhThlhs+lslhlss...................................................................................sllhu.shlhhs.hhl.AhRs+.s.sh..s.s...s.........psltth........................................................................................................................ctsh.tp..h+hhhhslsl.llu.lls.G.hhspup..Wt.plhha....hpussFGhpDP.FGhDluFYsFpL.Phhchllshl...hshllluhlssllsa............................................................................alhGul+............hss.t.t.s.t.l.ops.A+hpLullsulhhLlhAsuYaLcRYpLLhs.......ppss...hsGAuYTDlpAsLPuphlLhs..lul.l..sAlh.....h..................h..ss.l...................hh..+..sh+l................................Ps.l..u.hslhl.lsul..l.lG..s..h..a..PhllppFpVpPNttphEpsYIp+NIpATRpAY.GL..ss...lp.hp..s....a....s...u..s..ss......h.s..sp.p......................l.tsstsTlsNIRLhDPpllssoapQhQQ..h+saYpFs-.LslDRYpl...sGp...................................hpshllAsRELs.ssLstp.ppsWlNcHhVYTH.G..Ghlsu.uNpV.................s.ssGhPta..hlp...slsspuph..................slsl...ppPRIYaGph.......ss-YuIVGssts.....EaDYs................................................................psp...ts...sphoY...s.G...sGG....lslushhsRhlaAh+at-hphLhSstlsspS+.ILapRssp-RVppVAPaLTh.....D.....u....csYPsl..lsGR..............................lhWIlD...uY..TTsssY..PYSp..hsshtt....................tpplNYIRNSVKAsVDAYDGoVsLYth.Dpp..DPll+sWt+lFP.G.hh+shu-hs..s..-LtsHlRYPcDLFcVQpplLs+YHV.....sDPpsFasspDhWplPp.....-.............................s.s..s..sp.....spt.......................psPYYlhhp..h..Ps........pspsp...Ft..Lhosasshp......R.p.LsAa.luucS...Ds...........ssYG.....clplhp.l.P..p...s....s.l....GPtQspsphspssplSpplsLh................	1	84	173	210
+967	PF03676	UPF0183		Uncharacterised protein family (UPF0183)	Bateman A	anon	SWISS-PROT	Family	This family of proteins includes Lin-10 from C. elegans. 	19.80	19.80	21.20	20.40	19.20	19.70	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.37	0.70	-5.88	8	356	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	220	0	262	349	4	251.20	23	75.90	CHANGED	GsctWEFlLGMPIuQAluIIppQsplI+sVpVhYSDpsPLshDllIslPsDGl+LhFDPhsQRLKlIEVaslpplpL+YsushFNSPsllPTl-plpp.FGuTHPGlYDsu+plasLpaRGLSFtFPlsS.....+apssaucGLu...SLcFssGuoPlloRMSIYsGus.........lsEu+sP.sLPhuCahGslYhEpVcVl+puts.shGlcLpLsspG...shhhE.chpshpRplhFGDSsQDVhSsLGuPs+VFaKoEDKMKIHSsSsHR.spo+suDYFFNYFoLGlDILFDupTHcVKKFVLHTNaPGHasFNhYpRCpFpI.l.............sDpssssssspps........ITshoKWDplpchLusst...+PVVLpRuSospp.NPFGSTFCYGYQclIFEVM.Nsa.IASVTLY.sus	................................................h.........G....h.....phht.lp.t..t..h..hp..lha........t...tPht...s.lhl.hsttuhpLhF-s....QpLphI.........El........hs.......h..p........h.............hhat.............t...........................h.................t........................t............................s........s........h.tl....t...F.G.s.oa.......P..G..............t...................t......................ahL.a.GlsF.F..h....................................................ttst..........htp.h.la.utp.............h.ps........h.............................................................................................l.h.s.....t.o.s.p-lh..hG.......Pttha.Kt.pph.lH........................................................................................................................................Khlhhs.s...tp..h.............................................................................................................................................................................................................................................................ts......................................................................................	0	89	144	210
+968	PF03671	Ufm1	UPF0185; 	Ubiquitin fold modifier 1 protein	Bateman A, Coggill P	anon	SWISS-PROT	Family	This is a family of short ubiquitin-like proteins, that is like neither type-1 or type-2. It is a ubiquitin-fold modifier 1 (Ufm1) that is synthesised in a precursor form of 85 amino-acid residues. In humans the enzyme for Ufm1 is Uba5 and the conjugating enzyme is Ufc1. Prior to activation by Uba5 the extra two amino acids at the C-terminal region of the human pro-Ufm1 protein are removed to expose Gly whose residue is necessary for conjugation to target molecule(s). The mature Ufm1 is conjugated to yet unidentified endogenous proteins,[1]. While Ubiquitin and many Ubls possess the conserved C-terminal di-glycine that is adenylated by each specific E1 or E1-like enzyme, respectively, in an ATP-dependent manner, Ufm1(1-83) possesses a single glycine at its C-terminus, which is followed by a Ser-Cys dipeptide in the precursor form of Ufm1. The C-terminally processed Ufm1(1-83) is specifically activated by Uba5, an E1-like enzyme, and then transferred to its cognate Ufc1, an E2-like enzyme [2].	21.70	21.70	22.30	25.90	18.70	21.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.53	0.72	-4.22	2	177	2012-10-03 10:59:06	2003-04-07 12:59:11	9	5	139	3	104	152	2	72.40	75	67.89	CHANGED	uKVSFKlTLTSDP+LPaKVhSVPEusPFTAVLKFAAEEFKVPstTSAIITNDGIGINPtQoAGNVFLKHGSELRlI	............uKVoFKITLTSDP+LPaKVlSVPEu.TPFTAVLKFAAEE...FKVPs.sTS.AIITN.DGlGINPsQTAGNVFLKHGSELRLI............	0	41	60	83
+969	PF00179	UQ_con		Ubiquitin-conjugating enzyme	Ponting CP, Schultz J, Bork P, Finn RD	anon	Prosite	Domain	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-4.75	71	9194	2012-10-02 15:28:41	2003-04-07 12:59:11	21	127	571	270	5880	8415	316	134.10	27	49.81	CHANGED	Rlt+Ehp......ph.cpsssuhpst.hs....c.....slhpWpshIhGP.psTsY-uGhFplplpFPpcYPh.pPPpl+Fh..o......................claHPNlp.tsGpl......CL.sILp............pp.......WoP.shslpslLl.ol.uLL......spP.NspsPhss-sA...phapcs.pp...paccpsp.th	..........................................................................................................................l.p-ht........ph.....p...p......s.......s..h..p.s.t..s......p...................slh..p.W.ps..h.I..h..........G...P.......s.......s....o....s............Y...........c...G...........G..........h...........F.......p...........l..........p...........l.............ph..P.....p.............c.Y..P.........h..p......P...P....p........l......p...Fh...o..................................................p.l..a.....H....P.......N.............l......t....s...........s.....G..p....l....................C.L...s...l..Lp........................................p.p...................WsP...shs.l...p.......s......lLh...ul......p..u........LL.............................spP.....s....s...p....s...P.....h...s.....phu...p....h....h...p...p....t....ta.t.h....h.................................................................	0	1995	3131	4649
+970	PF02814	UreE_N	UreE;	UreE urease accessory protein, N-terminal domain	Bateman A, Finn RD	anon	Pfam-B_6279 (release 6.1)	Domain	UreE is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid.	20.80	20.80	20.90	21.40	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.02	0.72	-4.46	70	1294	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	1157	35	261	891	364	64.20	27	37.70	CHANGED	hls.shpthtt.tsss..ttplsLsh--Rp+pRhRhpsssGp.-lulpLs+s.sh.LpsGDlLht--Gph.l	.................h.........t...tttp.....s-plhLshp-ttKpRhRhsos...p.....Gp..-lulpL.tcs..hh...LpsGDlLht--sphl......	1	57	144	203
+971	PF04192	Utp21		Utp21 specific WD40 associated putative domain 	Wood V, Finn RD	anon	Pfam-B_16350 (release 7.3);	Domain	Utp21 is a subunit of U3 snoRNP, which is essential for  synthesis of 18S rRNA.	22.10	22.10	23.10	23.10	20.20	19.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.40	0.70	-5.26	28	330	2009-01-15 18:05:59	2003-04-07 12:59:11	7	21	284	0	242	331	2	226.30	30	24.85	CHANGED	hlEu..Ah--pppc........pppth.......YpSh-QlscsLlTLSlhPcS+apsLLcLDlIKpRNKPKEsPKtPEpAPFFLP.ossslsspt....................t.sspp........scstsctsclsclp.sspht..tpSpFopLLcp............usps..s-YsphlcaLpshuPuslDLEIRSLs.......s..hsshsElhsFlculsptLcop+sFELspAahulFLK.........lHuDllhp.......ssp.........................LtcsLppWpstpccphp+Lc-LVtastuVluFl+o	..........................................................ttt.ht...h.o..cQl......sp.pLlTLS.h.lPcS+WpsLLpLDlIK........pRNKP..........p........Es.PKtP..c...p.....APFFLP..ohsslssph.........................................................................................ptpp........................pppp..spt...sph.sph.p......t........popF...sp.hLpp......................................................................ut..ps....ss......asshlphL+sL.u.P.S.s.lDhEl.RoLs.....................s...tssh..pt.hht....F....l....c....hlsthLp.s+csFELsQAahulFL+.........lHschl.h.p....psp.................................Lhptlpphpp.p..ppphp+lppLht.shsllsalp.........................................................	0	84	137	203
+972	PF02151	UVR		UvrB/uvrC motif	Mian N, Bateman A	anon	IPR001943	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.60	0.72	-4.32	72	12483	2009-01-15 18:05:59	2003-04-07 12:59:11	14	46	4610	17	2727	9003	4562	35.60	34	5.61	CHANGED	pphlp.pLppchppAscppcaEcAuclRDplpplcpt	..............phlp.cLcpcM.ppAu.csh-FEcAAplRDplppLcp.h..........	0	966	1868	2351
+973	PF05008	V-SNARE		Vesicle transport v-SNARE protein N-terminus	Moxon SJ	anon	Pfam-B_5492 (release 7.6)	Family	V-SNARE proteins are required for protein traffic between eukaryotic organelles. The v-SNAREs on transport vesicles interact with t-SNAREs on target membranes in order to facilitate this [1].  This domain is the N-terminal half of the V-Snare proteins.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.81	0.72	-3.82	89	491	2012-10-01 21:14:52	2003-04-07 12:59:11	10	8	290	5	319	473	11	77.00	26	28.67	CHANGED	aptlpsplppclsphs..s...s..-..p++ptlpclcppl-EAppLlcpM-lEsp.sl..P...s.+sphps+lRpY+s-lsp.l+cchcp	..........................ap.lpsp.lppphsp.h.......phs.u..-.......p++phlpph-ptl-EAp-LlcpM-lEsc.sl....Ps.......stR...sthps+lRsY+p-lsp.l+pch+.....................	0	111	177	256
+974	PF00790	VHS		VHS domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain present in VPS-27, Hrs and STAM.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.53	0.71	-4.55	15	1706	2012-10-02 18:21:09	2003-04-07 12:59:11	14	40	287	48	1025	1655	5	130.70	28	24.38	CHANGED	ss.sp.lpthlp+ATcpsls-s..Dhuhhl-lsDhIsps....sssP+-AspsIpK+lss..psspsulhALslL-sCVKNCGppFHhclus+-Fhs-Llphlspcs.sc.....V+pcllcllppWspsh....cpcschphlpDhachLKhcG	............................s.....htthl...p..+ATs...t....t..h......pt...DW.s.h.h..c.lC...D...h...lspp............tsus...+....-Ah+u.lt++lpp..........pss...p...ht.........h.h.........A.........Ls.............lL-sslc...N..CGppFH..hp.l....u.........sc....c.F.l.s......c.l.l..c...ll.ps.ph.t.....st...................VppKllpll..psWs.p.s.h.....p.ps.ph..s..hltphap.LptpG.....................................................................................	1	272	484	768
+975	PF00654	Voltage_CLC	voltage_CLC; 	Voltage gated chloride channel	Bateman A	anon	wublastp P37020/1-588	Family	This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 (Swiss:P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney [3]. These proteins contain two Pfam:PF00571 domains.	23.80	23.80	24.10	23.80	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.28	0.70	-5.43	139	7727	2009-01-15 18:05:59	2003-04-07 12:59:11	15	38	3515	57	2231	6126	1048	337.70	23	63.73	CHANGED	lsuhls.......uhlhthh..sts...t...u.sGlsplhttl...pttpt.h.....lsh+shhs+hlus..llsluuGtSlG+EGPslplGAslushl..u...........ph......hth..ttsp.p+h.LlssGuAAGluAsFssPluGslFulE...............lh.tph..sh.......ps....hhsshluulsushlsphl........hu.t..sh...........as.....lss................hshhtlhhhlllGllsGl.hushFsphhhtsp.p.....hhpph.....h..............hh.pshlsuh...ll....uhlu....hhh.......................P.t..hhGsGh.......sh.........................................................................................................lpthh...sst...................................................hhhhhhhhhhlhKhlhTslohuuGhsGGlFsPsLslGAslGt.hh.....u.hlhthh........................h..................sshullGMuAhhuusspuPlouhlllhEhTu.shphllPlhlushluhhluph	................................................................................h..hhhs...shl...ht..hh.........stt...t...u......p...Gls.p.l...ht..tl......ps....h............................h.hps.hhhK.................h.lus..lls....lu..u...G..h..slG.............+...........E.............GPhlpluuslu.phlu..................................ch...............hp.h.......p.sc...p+h..llusGuA...AGluAsFsAPl..u....G.......slFsl.....E..............................lh..tph..ph...........................tshhss..hhu....ul.sushshphh..........hs.t..sh......................ht.............ls.h..........................................shs.h.t.p.h.h.hhll.l.Gl.l..s.....G..l.....hGhla.p...hhhthp....p.........................hhp..p....h........t.h.............hh..hshls..uh.lh.....ullu.....hh.h..........................................s..t..hhG...s.Gh...sh.......................................................................................................................ltthh.......tst....................................................................hshh.hlhhhhlhKhhhoh..lo.h...uuGhsGGlFhPsl......hl..G...uhhG.thh.....u..hhhshh................................................................................s..sh.hul....l...G.h.uuhhu..uss+s...................P.loshlllhEhT.......s..s.......h.p.......h...........l.hsh.hls.sh.huhhlst.h............................................................	0	710	1253	1782
+976	PF04840	Vps16_C		Vps16, C-terminal region	Kerrison ND	anon	Pfam-B_6003 (release 7.6)	Family	This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [1]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole.  It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport [2].  The role of VPS16 in this complex is not known.	36.00	36.00	36.20	36.20	35.90	35.60	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.73	0.70	-5.48	5	345	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	273	0	252	368	2	283.70	30	37.70	CHANGED	lSascIA++AYpsGRs-LApKLL-hEscuup+VsLLLpMccsctALpKAIcStDssLIhpVLLcLKpchspSsaahsLpcpPhAlsLYpcasRcp-+cT.......LaDlYpQ-DcapclApaHlcsuhts.ccs-uRlouLppAuDAaupu+s.slEscss-Dph....+Ll+lQcoLpccasssFssLSl+-TVscLI.sGcsK+AccL+p-F+IPDKRlaWLKlcuLuct+KWEELEcaApS.KKSPIGYtPFVchCl+pcNhcEA+KYlsR...lss.p-KVchalpsssas-Au-lAh-cRDtssLp-lhp+hssss-ushss+Vpsslcp	......................................................................................................................lSaspIAttAhppGRtcLAhp....LLphEspu.scQ..................VPLLLp........h.p.c...........pchA..LpKAlcSGDsDLlhhVLh.p.Lcp.c.h.s........h..u......p.....Fh.h.hl...pp....ps.h.........A...........s....L...ht.t.......hs.+..p....p.phph.................................Lc-ha......p.....sD...ph.....-hu...hh.lppuht............p.........p........................ps.........p..ht.......t..L....p.......At..c..h.h......t.p.s..+...p.......t..h...t...t...p...h..hp-ph..................pLLc.hQ.cpL..-....pc.....h...s.............t.............p.............F.h........s.h....Slp-T.lhpL...lh.....h.......G.p...t............+.........p.....Apcl.....tp-F.+l.s..-K+a.a.al+lpuLs.pt.cc.W...p..-L-....c.h........u........+......p...K.......K.S.......P.........IGapPFhphhh.p.t.s..p.t........t.p.At.pals+......lss...pp+hcha...hths.hhpAup.Ahct+s.t.Lt.lht.h.......................................................................................	0	95	149	215
+977	PF04841	Vps16_N		Vps16, N-terminal region	Kerrison ND	anon	Pfam-B_6003 (release 7.6)	Family	This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [1]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole.  It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport [2].  The role of VPS16 in this complex is not known.	22.00	22.00	22.60	22.40	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	410	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.35	0.70	-5.94	5	393	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	278	0	293	403	5	326.60	26	46.86	CHANGED	Pou-WphLcDs.YYRKptLuos-WsLch-l.chhlulAPaGGPIAVsRsP.phpss..hs.hPh..IpIashSGplLu+.lsWsp..sslVuMGWocsEELIlVsKsGpVhVYuhhG-h...paSlGcsl...pssclpEs+lFpoptGcoGVAlLssucclhllsusucslhh+phP...-lPsspophpstsssspI.....LssDcshpIhlssGssLt.Is-pu..ps.............lsS.p+alKloVS.s+p+LALYTsoGplhllSsDhuccLCEacls...t+usPKQMs..WCGN......DAVVlua.EshLhlVG.....csG-pVsFhYchT.sh..LssElDGVRIlTpoopEFLp+VPAsoENIF+IuSpsP...GAhLlEAtpchEc...+SsKA-EhLpplp-..pLccAVs-CIpAAscEFpPEhQKsLL+AASFGKuaLcpasPD..cal+	...............................................................................................................................................................................tW..h......hap....t.hh.t......a..............t...............h.......p...hhl.ss.us.uGsl....Alh.ps...................................t...........lplas.s.G......l.tp...h.a..pt.............s..lh.thsW.st....p.-pLl.sl..psGh.h.h.h.a........s.h.....uph.................h...s.h.sp.th....p.tl..p..s..............................h.sG.hsh.....l.h..t.s....p......h..h.h..tsh....t...............t..h.................t...st........................................................h.........p...p...h......l...hh..s.....s.....plh.l.....ttt.......................................h........................hhphslS.stp.hl.Ahh......s.....t.s....G.....h...l.....h.h..h........s.s.shp..p.h.h...-hss.p.....................pt..P.p..ph...WCup.................c..ulh.l........ta...p............p.......lhllG...............................stsp...h..pa..h.s....t......h........................lhsEhDG.lRlh..opsph-hlpc...VPt...s...s...........tplFplu.S.h..sP...........uuhLh-uhcphpp.................pu.....+A.--...lp.l..pt.........pL.pAVppClpAAst.E.a...psp.hQ+p...LL+AAsaG+sh.hp..h..p............................................................................	0	115	177	250
+978	PF03635	Vps35		Vacuolar protein sorting-associated protein 35 	Finn RD	anon	Pfam-B_3569 (release 7.0)	Family	Vacuolar protein sorting-associated protein (Vps) 35 is one of around 50 proteins involved in protein trafficking.  In particular, Vps35  assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps26 and Vps29.  Vps35 contains a central region of weaker sequence similarity, thought to indicate the presence of at least three domains[1].	21.20	21.20	21.30	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	762	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-13.43	0.70	-6.39	23	430	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	295	2	300	460	7	646.70	38	90.35	CHANGED	+hLpEAlssV+pQuhhM++sL-p.scLhDALKauSsMLsELRTusLSPKpYYELYMtlFDpLphLssaLt-p+spt.++..........................LsDLYElVQaAGNIlPRLYLhITVGosYlcsp-uPsKEILKDhlEMCRGVQHPlRGLFLRaYLsQto+-hL.Ps.s....................ppsssGslpDol-FllsNFhEMNKLWVRlQH.....................................QG.s..............+-+-+Rp+ERcELplLVGoNLVRLSQL........-GlshchYpcsILPplLEQlVpCRDslAQpYLhElIlQVFPDEFHLtTL-.LLsus.spLpPsVsl+pIlhsLl-RLusYsspps-sp.p..t..........................................................................................................................................................................................................................slclFplFhsplspl........lc.s+schs..........................................................................................................................................lpshlsLhsSLlsLsLpsYP..-pl-hl-plhshshp.hlpph........tsphpsspsppplh...................pLLhh.................Pl.pp........ahshhslLplpsa.sLlshhshps.pKsluhsllssll.....................cssoh...................................Issh-pl-plhpllpsLI...................p-psDp..t.....................................................-s--ht-EQphlu+llHll....p.s-........Ds-pphclLtssRKthhpGG.pRl+aThPsLlhshl.........+Lsp+hptpp.............................................................................................papspspplF+alHp..slssLhshss....s-LsL+LaLpsAtsADphs.............lp-...luYEFasQAFslYEE......................sluDS+sQhpAlthlluoL.p+h+shs..cENY-sLhsKsshauSKLLKKsDQCRuVhhCSHLaWssch.........................................................h+-uKRVLECLQ+uL+lAcsshp.......sssslpLFVElLN+alYYa...-pssspVoscalssLI-LIpssh	................................................................................................................................................................................hLt-ultsl+.psh.M.....++s...L-p..spLh-ALKpuophlsEL...........R.....T.....s.LuPKpYYEL..................Y.....MtlhDt.Lp.hLphaLh......-ph.t.....pp......................................................................ls..DLYE.lVQauGNIlPRL.YLhlTVGssYhp......t..t....sh+-lhKDhhEMsRGVQHPlRGLFLR.YL.phs...+.shL.Ps.s........................................ptstGslpDuh.pFlL.NFhEMNKLWVR.h..Q.H.......................................................QG.u..............+-+-pRppERpELplLVGoNLVRLSQL....................t.lsl-hYpphlLstlLEQlV.pC+DslAQpYLh-slhQ....V....FPDEaHLpTLs..hLpus.spLps.....pVslK..............pllhsLh-RLutastppsts..................................................................................................................................................................................................................................................tplclFphF.pplspl...........lp...sp.phs.............................................................................................................................................pshlsL.suLhslsh...p.haP...........-cl.-a.l.DplLthshp.hhpph..............tt.....psstsp.pplh...........................tLL.h........................Pl...pp........a.slhshLpL..pa..lh.ph.s.hts.p+thuh.llpsll................cp.p.s.h...................................lss..-p.....l-tlh.pllpsLl...................p-t....pt.s.t........................................................-s--hh-EQshluRhlHh.l........p..sp.............-s-p..phtlLphs++thh....tG.s...pRlpaTh..Psllhssh.........pLsh.phpt.p.........................................................................................................................................tpphptpspplapahpp..slssLhpt...................s-LsL+L...aLpsu.sAs.p.hs.....................hEp...luYEFhsQAFslYE-........................pI.u.DS+sQhtAlphIhush...pp..........hpshs....pE.N..a-sLhspsshhuuKLLKKsDQsRuVh..hsuHLaWssp..........................................................................h+sucRVh-CLp+uL+lAstshc..................sshplpLalElLs+Ylaaa.....-pt.stt....l.ohphlstLIphIppp.h...............................................................................................................................................................................................	0	117	178	255
+980	PF04129	Vps52		Vps52 / Sac2 family 	Wood V, Finn RD	anon	Pfam-B_10164 (release 7.3);	Family	Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events [1].	22.60	22.60	22.90	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	508	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.63	0.70	-5.98	5	461	2012-10-03 17:31:52	2003-04-07 12:59:11	7	15	279	0	310	506	9	381.30	24	70.45	CHANGED	lEpcSIcDhIp...............................ESpNluoLHNQIsuCDuVLscMEshLsuFQs-LusISoDIcpLQEKSscMslpLcNRpuVcu+LuphV-DllVPP-LIcsIl-GcVsE......spasopLplLs+htusscDQu.....s+uopAsKDVc...slLDKLRsKAlsKIRcaIlpKIhsFRKPh.TNhQIlQs.sLLKaKaaapFLhcNsRclAhElRsAYI-TMsKlYhuYF+uYlppLsKLQa-cusop.DL.hGVE-sus.......uLFFS..............KssoL+p+sslFolGcRssIls.tpl-sPllVPHIApssp.+YshEsLFRShchALlDNuosEYhFlsEFFslsGsptc-l...FppIFu+TLohspKalpslIusCaDsIGlhLsIRllp+aQLhup+RsVP.sLDsYa-ulllhLWPRFchVhDhplpSLRcssloshst............h-o+PHYlTRRYAEFouSllsLulsassup...lspLLscLpp-V-sFlL+lAKpFsc+KcQllFLINNYDhlluVLpEtus-suKEscsFpEhLNusospFl	..............................................................................................h...t.h.tttl.t.t.spthl.t...p.hc.......phLttFpscLsslos-lppLQppS.ths.pLpNRpthpt.Ls.hlptl..lssthlp.Ihp..s.....lsc......................h...t....p..............p..ph.h...h...........tp..t.....................................pt...tu.....ht-lt...s.lppLp.+...........Aht+l+............cal....l........t....p...l.hthR..........ps..................hN.......hQ.....h.Qp...th.......l.+.h.+............hh.tFLhtpt.thstElpptYhpTh.ph.......h.ah....sha.p.pY..ttL....p....lphp...hspt...sl...s..tt...t...........................t..h.......................................................t..ttha....t.lspR.h.pllp.....p.......p.t..........s....h......h..........................s.......h........s..........pt..............s.......t.............h.....................h...EhhFRs.phhLhDssstEa...........Fh.pFF.........................tph.........................h.tlh..t.sht.hh.p..hp.........p..h.l..t..............t..s..h.D....shulhl..hlpl..p.h.t.........h.t.p.R.....p..l..s..sh-.....ta.hpth...lWP+hp.lhphphpS.lp...p..h.s......t.......................................t.ts.+....ls.ppauph.tuhl.l....s..............t..h....pt.........................h......h.pl......t.hpthh.th......s....t.........................p........p......t.t....haL.hsNY.hhhsh......l......p..............................................................................................................................................................	1	127	191	270
+981	PF04100	Vps53_N		Vps53-like, N-terminal 	Wood V, Finn RD	anon	Pfam-B_5601 (release 7.3);	Family	Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events [1].	24.00	24.00	24.20	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.37	0.70	-5.68	7	406	2012-10-03 17:31:52	2003-04-07 12:59:11	7	9	287	0	282	410	14	328.10	31	47.32	CHANGED	tschssl-hINplFPs........................-tSLssl-plh.......p+lpt-Ip+lDssltshVcspsNsGpcup.sLp-AppulppL.pcIp-l+s+AEpoEthVp-lTcDIKpLDhAK+NLTsolTsLp+LpMLssuh-pLpthhppppYuchhs.hpuhhplh.phFptYpsl.pItpLppplsphptphhpplhpsapphF....ustsppc.u..hphLsDuChVhssL-ssl+cpllchFhpppLp-YhplFt-spEhuhLDcl-+RYsWhK+hLpsa-pt.htslFPtcWchshRLshpFC+.TRppLtpIhhp..+ccc.slclLlhAlppThpFEphLs+RF.............................p...E.c.ht.......................FcshlSSCFEPHLslYIppp-ppLtchh-phsp-.ph	..............................................................t..casslpalNthFsp..........................po...L.s.s.lsphh...........pplp.php..pl-ppIt....ph.lpt..Qs...............ss..ppu.ptlppA.p.tsl..................t.pLht+Ipcl+p+AtpoEphl...pphTpDIK.pLDhAK+pLTtohT...sLp+LpMLs...............suh-pLpt..hsp.p.....+.p....Yt.-sup.L.................p..ulhplh.paF.............p...pY.p.s......ls.p..ItpLppplpthpppLhpplhtD.Fc...h.a........................st.t......t..p..........p.Lt.-uCh.VhssLss..p..h+..pcllphahp.pp.LppYt.lF.p..................ts.p......-......su.L.....DplsRRYsWh++hLhsa-pp...h.....sthFP.pWphsp.tlshtFCchT+pcl.......t....tlhtp................ptp....ph..-...VplLL.slpcThpFEp.Lsc+F.................................................................................t........................................................................................Fp.thlSpsF-PaL.tlalctp-+pLtphl.phht....t.................................................................	0	109	172	243
+982	PF02204	VPS9		Vacuolar sorting protein 9 (VPS9) domain	SMART, Eberhardt R	anon	Alignment kindly provided by SMART	Family	This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.18	0.72	-4.00	49	1496	2009-09-12 00:55:57	2003-04-07 12:59:11	13	121	301	10	1005	1449	9	105.40	25	12.44	CHANGED	hpputpcLppl.sph..poPp-Klphllpspchlhpsl................................tttstshuAD-hLPlLlalll+ups..pL..huslpalpp.........F........................h.psshhpu........EtuYhLTshpuAlpalcshsh	............................................h..tAhpcltpl...sph....psPpc.Klthlh.....pss...chIhpsh................................................................................................t..t.ppsp.shuAD-hlP.......lLl.Ylll.......+u............s...............pL..........huplpalpc.........F................................................................................h...tssh.hp.G...........E.tuY..hlTsl......p.uAlpalpph..t.....................................................	0	361	525	776
+983	PF03302	VSP		Giardia variant-specific surface protein	Mifsud W	anon	Pfam-B_4536 (release 6.5)	Family	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.42	0.70	-13.07	0.70	-5.83	6	1081	2009-01-15 18:05:59	2003-04-07 12:59:11	8	16	13	0	430	1062	0	178.50	20	59.27	CHANGED	CstCpsGYclSsDKTpCsuou..sCps-NCKsCSs-c+..psCp-CsSssYLTP.TpQCIDsCtKIGNYYssTsupsKplCKECssANCKTC-spGpCpsCsDGFYKsG-sCuPCcpsCKTCuuGTuSDCTcC.oGKsL+YGsDGTKGTCGtGCsTGsGuG.ACKTCGLTIDGsSYCSECAspTEYPQNGVCoSssuRAssTCpsuslAsGhCuoCssGah+MNGGCYETTKaPGKSVCpsAsuuG.TCQKtAsGY+LssssLssCS.GCKpCoSsTsCTsCh-GYVKo..osuCsKCDuoCcTCT.GusTsCcsCuTGYYKouospsuCTus-SD.pslTGVpsClsCAPPssspGSVLCYLIKDu...G.STNKSGLSTGAIAGISVAVllVVGGLVGFLCWWFICRGKA	...........................................................................................................s......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	430	430	430
+984	PF00092	VWA	vwa; 	von Willebrand factor type A domain	Sonnhammer ELL, Bateman A	anon	Prodom	Domain	\N	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.17	0.71	-4.55	189	10632	2012-10-10 16:07:06	2003-04-07 12:59:11	23	753	2209	191	4154	16265	2130	166.70	19	31.03	CHANGED	DllhllDuSsSlst.....tp.....app.s+palppllp.th.t.......hstpssplullpauspsp............h.hslssh..pstpphhptl...........tphhhhsusTp.hup.ALphshpphhpt..........ttssRt...sss+lllllTD.....Gpssss...tthstthppt................slhshulGh.......................psstppLpplu..s.tt..pphhhhpshpt................phhppl	............................................................................DlsFllDs...S..sS...lst.................................tp..............................a.pt.....h+...p...a.l..t.....p.llp..ph..p...........................hu..t...pp.s.+.......l.....u....l.l..p..a...u...s..p.sp....................................................s.h..p...ls..s.h.........p.s.t.p.....p.lhptl.................................................pph.h.h.h.u..u..s...T...t....s..u..t.......A..L...p...h...s..h...p.p.h.hpp.........................................tsR..........ps.s....p....l.......l.l.l.l...T.D.........................G...p......s.....s.......s...p.................h........t............h..t....thppt................................................sl.h.h.hulGh..................................................pss...p.p.L.ptls.........................h......................h...........................................................................................................................................................................	0	1087	1482	2603
+985	PF00094	VWD	vwd; 	von Willebrand factor type D domain	Bateman A, Sonnhammer ELL	anon	Dotter	Family	Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.27	0.71	-4.06	62	4125	2009-12-18 15:39:34	2003-04-07 12:59:11	20	537	352	0	2288	3757	7	145.50	21	18.65	CHANGED	Csl.Gs..chpTFDGtpYsaps....ss.....sah..lspssssp..........hphhlt.ppsstsssth...h.pplplhht.............shplphtts.......htlhlsspplsh....shttssh..tlphhs........tshhhlth....thshpl..hphcs...tlhlplstthpspssGLCGsassctpsDhhpssGp	................................................................................................................................CtshGss.HahTFDG..t....has.F.G............sC....................pYh.......Lsps.s.ts.p................................phtlp..h...p.p...p..s.t....s..p.pt.h..............h.hpp.lpltlt............................................shplpltps................pl.h.l.ss.p.t.hth...............Pht.tsh.....tlphht................................t.t...hhlth........thshtl....h....p.h...s.......s..............pl......h.l.p..l...s.s............p....a....t......s....p.....s..s...GLC..G.sa.ss..p..p.sDhhh.ss...................................................	0	497	686	1444
+986	PF00095	WAP	wap; 	WAP-type (Whey Acidic Protein) 'four-disulfide core'	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.55	0.72	-3.99	72	1589	2012-10-02 12:37:03	2003-04-07 12:59:11	16	122	164	5	826	1565	1	44.60	36	19.27	CHANGED	KsGpC.P............tttt.Ch......ppC.psDpcCss.spKCC.........s.u.C.Gpp.ChtP	..............KsGtC.P.........................tttstCh.............ppC.....p......sDpcC..ss.....tp.....K...CC..........s..u.C..Gpp..ChtP...........	0	219	260	462
+987	PF00400	WD40	G-beta; 	WD domain, G-beta repeat	Finn RD	anon	Pfam-B_2 (release 1.0)	Repeat	\N	21.00	12.10	21.00	12.10	20.90	12.00	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.75	0.73	-7.90	0.73	-3.89	1804	193252	2012-10-05 17:30:42	2003-04-07 12:59:11	27	2206	1701	1549	125805	189768	5414	38.20	23	20.36	CHANGED	tphhtsh.puHpsslpslsasss........................sphlsouu..tDssl+lWc	............................................................................h......h.puH.p...s...s..V..p....s.l.s.asss.............................................................................sphlso..uu..............tDtsl+lWs...........................................................	0	44330	69386	100531
+988	PF00568	WH1		WH1 domain	SMART	anon	Alignment kindly provided by SMART	Domain	WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha  and mGluR5 bind a protein called homer, which is a WH1 domain homologue  [2]. A subset of WH1 domains has been termed a "EVH1" domain [3] and  appear to bind a polyproline motif.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.44	0.72	-4.34	8	1177	2012-10-04 00:02:25	2003-04-07 12:59:11	18	30	236	25	600	1088	23	104.80	28	24.22	CHANGED	huh......psIsouhAplahh-sss+c.Whhs....ppsusVshh+DsspNoYhlhuhclp.cscllhspplhsshpYspsoshFHpapsscs..hhGLNFuSE-EAspFtcthpcsl	...................................................tt...........slhp.s.hApVh....hh......-.ss.s....pc.....Whsh.......pthusVs..h.....h.....p......c......s......s.....p...s.........s...........a....hlhuhc.h...........p...sp...p............lllsp......p..l.h.......p..s.........h..p...Y...s....p.....s.....s........sp.....F....H..p..W...........p.s.....s.c.p...........haG...L..sFu..Scp-Ap.....p...Ftcthpc..h...............................................	0	159	234	397
+989	PF02205	WH2		WH2 motif	SMART	anon	Alignment kindly provided by SMART	Family	The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP Swiss:P42768 and Scar1 (mammalian homologue) to be the region that interacts with actin.	23.10	13.00	23.10	13.00	23.00	12.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.37	0.72	-4.21	57	1560	2009-01-15 18:05:59	2003-04-07 12:59:11	15	69	271	11	837	1462	8	26.60	38	5.24	CHANGED	ssssRuALLusIppG..t..LKKs.posD+S	.........sssRsuLLssI+pG....hpLKKs.pptp..........	0	213	324	544
+990	PF02467	Whib		Transcription factor WhiB	Mian N, Bateman A	anon	Pfam-B_2249 (release 5.4)	Family	WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	22.80	22.80	22.80	23.00	22.40	22.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.62	0.72	-3.67	8	2386	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	569	0	664	1645	791	66.10	42	61.73	CHANGED	WphpAlCRssDP-hFF.P..-RG..pusR-..AKclChR.CPVhpE..CtAaALcscctaGVWGGlSE.....cERRtL	.....................................WptpAhC...t.....p..t.....D....P.-....hFF...P.......ppG.........t.s..pcc.........AK...tlCtp.CP..Vppp....CLpa.....A......L........p......s....s........p......c......a........GVW...G...GhoE.......cERRtl........................	0	218	497	614
+991	PF02019	WIF		WIF domain	Bateman A	anon	[1]	Family	The WIF domain is found in the RYK tyrosine kinase receptors Swiss:P34925 and WIF the Wnt-inhibitory- factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge.  This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt [1]. The WIF domain is a member of the immunoglobulin superfamily, and it comprises nine beta-strands and two alpha-helices, with two of the beta-strands (6 and 9) interrupted by four and six residues of irregular secondary structure, respectively. Considering that the activity of Wnts depends on the presence of a palmitoylated cysteine residue in their amino-terminal polypeptide segment, Wnt proteins are lipid-modified and can act as stem cell growth factors, it is likely that the WIF domain recognises and binds to Wnts that have been activated by palmitoylation and that the recognition of palmitoylated Wnts by WIF-1 is effected by its WIF domain rather than by its EGF domains. A strong binding affinity for palmitoylated cysteine residues would further explain the remarkably high affinity of human WIF-1 not only for mammalian Wnts, but also for Wnts from Xenopus and Drosophila [2].	25.00	25.00	26.30	25.90	23.50	18.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.79	0.71	-4.71	10	223	2009-01-15 18:05:59	2003-04-07 12:59:11	13	21	84	5	144	241	0	122.70	35	26.76	CHANGED	laIsccEV++Ll......GlsA-lYYl+sGtlNsYuhc.....F......hlsVPS-VsslsFTWpS.uppcYhYuFsl.hosDpplLstPslsIsppGcVPpshpsFulsL.CoGspuGpsshslsLplpsscsh..ssTsLph+p+KhC	...................als..ph.hhh......G..l.p.t-..lahVcpGhlspashs......F........hhslPuplpplpFT.Wp.uh.u....ph.phhYshps................s.c.............tshhstPplNIshpGpVPp....p....hp.sapV....tLsCo.Gphsupsshplpl.lpsspt....ssThLph+ppKhC..................	0	30	41	95
+992	PF03106	WRKY		WRKY DNA -binding domain	Bateman A	anon	Pfam-B_85 (release 6.5)	Domain	\N	21.00	21.00	21.00	21.10	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.07	0.72	-4.13	34	3051	2012-10-02 23:28:20	2003-04-07 12:59:11	10	33	220	3	1178	2878	5	54.90	54	20.61	CHANGED	hcDGYpWRKYGQK.VKGu.aPRSYY+CTps...sCssKKpVERustDsphs.hsYcGpHNHsh	...........sDGYp.WRKYG.QK.sl.KGsP......h.P....R....u..........Y...Y+...Cop......sCss+...K....pVp.......R...s.t.....p..........D......s....p......h......h.........hsTYcG.pHsH..............................	0	150	687	953
+993	PF02206	WSN		Domain of unknown function	SMART	anon	Alignment kindly provided by SMART	Family	\N	19.50	19.50	19.50	20.10	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.99	0.72	-4.23	36	345	2009-01-15 18:05:59	2003-04-07 12:59:11	13	36	5	0	343	301	1	68.00	24	6.39	CHANGED	ssLpphhcphphluRlsNuIsLQtulhssoIshc-lluELLphsss.shsplhslcs...spltptlpplpch	...........hpphhcchphlARlsNuIsLQsulhs.sol.shcclIuELLslssh..phsplhshc........pplpphlppl...h................................	2	57	110	343
+994	PF00397	WW	WW_rsp5_WWP; 	WW domain	Finn RD	anon	Prosite	Domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.62	0.72	-4.06	547	8927	2009-09-12 21:03:02	2003-04-07 12:59:11	21	403	357	119	5200	8316	391	30.00	36	6.13	CHANGED	hsss.W.p.thh...ss.....GchY.YaNppTppopW-cP	..........LPsG.W.c.pphs..sp....GchY.YhscpT+.pTpWccP.....	0	1588	2359	3759
+995	PF02825	WWE		WWE domain	Aravind L	anon	Aravind L	Family	The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.29	0.72	-4.55	14	1021	2009-01-15 18:05:59	2003-04-07 12:59:11	15	76	133	6	601	935	23	72.80	24	8.55	CHANGED	hststtshhW.ap....sssspWpsYs.ps..pppIEsuaptpcp.....hlp.l..shhGtsYhlshpsMpQhpptss.....thRtV+R	.........................s.......hhWpap..........scpup...WpsY......s.........tp.s...........spp.........lE.p.uap.pspp...............sls...h............ss..t....t...h...t.Yhlc.....hps..M..p...Qhsppos............ptRtl+R......................	0	158	223	410
+996	PF02706	Wzz	wzz; 	Chain length determinant protein	Bateman A, Mian N	anon	Pfam-B_1977 (release 5.5)	Family	This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps [1]. This region is also found as part of bacterial tyrosine kinases such as Swiss:P38134.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.63	0.71	-4.39	38	7377	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	3167	41	1494	5501	1022	184.60	16	39.45	CHANGED	scIDLhcLlttLh+p+hlIlhlsllhshhuhhYs..hhssPpYousshlhVspppt..........h...........sl.ssh......p.hs.shhcllpSppllpclhpclplt........................................................................................................................t.lpp.lsl..s.tp.potllslshp.spssppspplssplsps	.........................................................pl-lhpl....ht.h..l.......hc.......t....ph.h.l.l.hh.s.h.l.h...s..h...l..u.h....h.h...s....h..........h.......h..........s.....s.p...Y..pus..u..h....lh...l.tppstt...................t............t...........s.h....s.st...............................p..h.hs....s..h..h...p..ll.p....S....p.........pll....p....cs..h.p.p..h.slth.............................................................................................................................................................................................................................................................................................................................................................................pt.l..p.p...t..l.pl.....p......................t....po...t...l..l....s..l..s.hp....sps..p..s.t.plhsth...h.............................................................................................................................................................................................................................................................................................................................................................................	0	472	948	1240
+997	PF03254	XG_FTase		Xyloglucan fucosyltransferase	Bateman A	anon	Pfam-B_3419 (release 6.5)	Family	Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residue [1].	20.40	20.40	20.70	20.50	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.64	0.70	-6.00	29	257	2010-01-08 15:56:59	2003-04-07 12:59:11	8	7	32	0	171	248	4	376.80	37	79.45	CHANGED	lllu..............ptthsshhspttsssss.hspssptspD....+LLGGLLusGFDEpSClSRYpSu.LYRK.sSsa+PSsYLlSKLRpYEsLHKRCGPGTcuYp+AlcpL...puu....pssuss.....-.CpYlVWlshpG..LGNRhLolASsFLYALLTcRVLLVD...up-hu-LFCEPFPsTSWLLPh.DFPlps...hpuasppsscsYGsML+scsIsss...............t...PsalYlHLsHshpc..tDKh.FFC-c-QshLc+VPWLll+oDsYFlPuLFLlPuFppELs+LFPpK-oVFHHLuRYLFHPoNpVWGllTRaYpuYLA+ADERlGIQlRVFsppsssappVhDQIluCTpcE+LLPcl..sspps..........ssssupss+.KAVLlTSLh.stYaEpl+sMYWc+PTsTGElluVaQPSHEchQppspphHstKAhAEhYLLSLoDslVTSuhSTFGYVApGLGGL+PWlLacPps..tpsP..sPPChRuhSMEPCFHsPPhYsC+u	...........................................hh.s....................................-....tLhsGLL..s.s..s..h.s.ct..oChSRapt..h.a...h+.................h.....sSsaLlp+LRpaEthp+.+CGPtTt.YppshppL.pps..........t.t..sss......t..C........pYlVh.h......s...h..p.G..LGNRhLshsSsFLYAlLTsRVLLV.....c........st.c.h.ssLFCEPFPs......o.oWhL..P.................c..F..Phtt...........httht...tt.csa.sshlpp.phht.ss.................PsahalpLtts...t............-.p.h.F...aC-csQ..th..L.p..plsW.ll.hp.oD..YasPuLF........hhPtappE.Lp.phFP.p..+-.sVFHaLuRYLhHPsNplWt.hlp+.a....apuY.Lut.u.s.cp..lGlQ.lRh...a..t......t.....s.......h..p.h....hc.Qlhs.Cs.pc.p.lLP..pl....tttt....................sst.tstp.puVLlsSL..s.Yh-pl+shYhp.............pssh..sG.....-..h.ltVaQ....PSH.....EthQ.p.tpp.Hs..KAhAEhaLLShsDhl.lTSu.hSTFGYVA.pGLuGlpPW.lhh.p..t........ttss.....p.ssChpshShEPCha.PP..htCp....................................................	0	33	90	137
+998	PF05181	XPA_C	XPA;	XPA protein C-terminus	Studholme, DJ	anon	PF02186;	Domain	\N	25.00	25.00	25.20	25.40	24.20	24.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.47	0.72	-4.37	16	261	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	237	2	182	251	2	51.70	54	16.42	CHANGED	-KYSLLTKTEsKpDYLLTDsELcDcE.LLs+LtKsNPHpusaucMpLaLRhQV	......-KauLlTKTEAKp-YLLpD.......s-LcccE..lL.altK.NPHpupWucMpLaL+hQV.....	0	58	94	146
+999	PF01286	XPA_N	XPA; 	XPA protein N-terminal	Finn RD, Bateman A, Studholme, DJ	anon	Prosite	Domain	\N	27.10	27.10	27.10	27.40	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.95	0.72	-4.27	10	119	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	95	2	72	115	0	33.60	52	11.78	CHANGED	.-Y.hC--CsK.FMDSYLhspFDhsVCDsCRDs-	....sashCcECu+pFhDSYLhspFDlslCDsC.RDs-....	0	23	31	52
+1000	PF00102	Y_phosphatase		Protein-tyrosine phosphatase	Sonnhammer ELL, Griffiths-Jones SR	anon	Swissprot_feature_table	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.81	0.70	-5.02	114	7626	2012-10-02 20:12:17	2003-04-07 12:59:11	22	291	589	328	3916	9772	240	210.40	29	34.46	CHANGED	NhpKNRatslhshDp..oRVtL.................................t..s.sD..Y..INAsal....................uht.t...tppaIsTQuP.......l..................pTh...pDFW+Mlapp..p.spsIVMLsphhEt.........sp......KCspYWP.........pp..shpaGs.hpVphh.......ppp.tptshhl+phplp.....p....tspp...............................ppl.ppapap....sWP..Dps.......lP..ps.....spshl....phlcplcptp...................tsPllVHCS.....AGlGRTGsalslchhhpplcp.......pth...lclhp........hlpplR.ppRsthVQo......pQYhFlapslhc	.................................................................................................................................N..KN.Rh......s.l...h.........s..h......-..p..sRVhL.............................................................................................................t.....s-.......Y.....I..N...Asal..........................................................pshp..p.........ptaI..so...Q......u..P...............l...................................................pTh.......tDF..WpMlacp....................p......s..t......h................I.VMlsph..Eh......................................sp...............KC.tpYWP.................................pt..........shp.a.....s....t......h.p.Vphh...................ppp....hsp.a..hhR..p.h...pl.p.....p.......tppt........................................................................................+pl....ppa.pah........s.W.....P....-pu................................................lP......pp...............spshl............phl.p.p.lpptp.............................................................................ttsP..l...l.VHC..S............................AG.sG.R........T.G.....s...a...h...s......l.s..h.h.h..p..t..hcp...........pth.........................lslh.p.......................................................hl..p.p..hR...p.p...R.s..t.h.lp..o.........................pQ..Y.Fhapsl.......................................................................................................	1	1277	1669	2915
+1001	PF04893	Yip1	DUF649; 	Yip1 domain	Finn RD, Bateman A	anon	Pfam-B_5598 (release 7.6)	Domain	The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases [1].	30.90	30.90	30.90	30.90	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.47	0.71	-4.76	208	1661	2012-10-01 22:34:14	2003-04-07 12:59:11	12	30	827	0	929	2057	257	174.80	14	66.95	CHANGED	lhhpPsph.appltppt..........................hhhhhhlhshlshlhshhhs.........h...h.........................................hthhshhts......hhshhlhh.......hlshhlhuhlhth.......hsphhs.......upss....htp....shslhuas...hhPhhlstlhshhhhhhh.........................................hh.hhlhshWsh..hlhhhulttshphsth..puhhhshh.......shllhlh	.......................................................................hp.tth.hpchht.hh.........................................................tp.cLh.uslh..hs.l..shshhlhhs...................................................................................th.h.shhuh................lhhshh...........hlshhlhshlhhh.....................h......hs...................ushs.....ahp..............shs.l.h.GYs....hlP.h.s.lssll.sh.hh..hhh.h........................................hhh..shlhhhWsh....hhhshhh.tthh..t..h........t.hh....................hhhhh........................................	0	325	549	754
+1002	PF03226	Yippee-Mis18	Yippee;	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly	Mifsud W	anon	Pfam-B_2930 (release 6.5)	Family	This family includes both Yippee-type proteins and Mis18 kinetochore proteins.\	Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus [5].	24.80	24.80	24.80	24.80	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.82	0.72	-3.94	54	862	2012-10-03 11:08:31	2003-04-07 12:59:11	9	10	301	0	600	712	1	97.00	39	59.44	CHANGED	hVFpCtpCpshLuDShshls.......pspp........psllh......................p...plsssVhlscphhsup.p.t......sshpslhCptCstslGhhYhsospp.hshhcshFslphcplpsYp	.........................................................p.hasCtpC+scLusps-lIS+.....................shpGtps.......+AYLF...................................................................sp......llNls.pu....s...p.-RhhhTGh.............HsVsDIhCpsCpstLGWKY-.....pAhEpoQKYKEGKaIlEhtth....h............................	0	172	307	445
+1003	PF02757	YLP		YLP motif	Ponting CP	anon	Ponting CP	Motif	The YLP motif is found in several drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues and its presence in Swiss:Q15303 may suggest it could be a substrate for tyrosine kinases.	25.00	5.00	25.00	5.10	24.60	4.90	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.31	0.76	-5.60	0.76	-3.38	26	674	2009-01-15 18:05:59	2003-04-07 12:59:11	12	40	12	0	397	674	0	8.90	65	15.78	CHANGED	usEYLPPsp	..usEYLPPsp..	0	60	60	245
+1004	PF04146	YTH	YT521-B; 	YT521-B-like domain	Bateman A	anon	Pfam-B_1386 (release 7.3)	Domain	A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells [3].  It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing.  The rat protein Swiss:Q9QY02 YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner [1]. The YTH domain has been identified as part of the PUA superfamily [4].	21.40	21.40	21.40	23.30	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.53	0.71	-4.58	59	968	2012-10-02 17:37:24	2003-04-07 12:59:11	10	23	252	2	553	870	5	142.90	42	23.91	CHANGED	su+aFlIKSho.t-slctSlchslWuoospss........c+LspAacpsp..........sVaLh.FSVNtSGpFtGhAcMhos.lshs...................................................................................................pss.hW..................................................................tp....casGs.FplcWlhlc-lP.pph++l.......hss...-s+sVphuRDspElp.phGhpllplFcph	........................................................................................s.sRaFlIKSho..c-cl+cSl+as.lWsST..psN........++LssAa.+psp...................sVaLl.......FSVNsSGcFsGhAcMtos.lcas.....................................................................................................................................................................................................................................ps.sshW....................................................................................................................................................................................................tt.......t+WsGh.FcVcWl..hl.+DlPssph+Hl.......p.p..N-N.....KPVstSRDsQEl..hc.pGtpllplht..h.........................................................................................	1	150	268	403
+1005	PF00643	zf-B_box		B-box zinc finger	Bateman A	anon	Prosite	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.88	0.72	-4.06	106	7772	2009-09-12 06:38:22	2003-04-07 12:59:11	19	359	385	16	4488	6434	9	43.10	26	9.16	CHANGED	pptthC..spHp.....p.p...hphaCpsCpp.hlCppChhtt.......H..ps......Hph...hsl	........................t....hC...spHp................c..p.....hphaCp..s..s..pp..hl.....C.h.h..Cphst.............H..ps...................Hphh...............................	0	1713	2306	3263
+1006	PF02892	zf-BED		BED zinc finger	Bateman A	anon	[1]	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.41	0.72	-4.20	41	1403	2012-10-03 11:22:52	2003-04-07 12:59:11	10	85	169	2	872	1516	7	47.30	26	9.97	CHANGED	utsWcaFphhp.......tcppspCpaCtKthstt.........GTosLpcHL........hptpp	.......................s.lWpaFphht.............tpppspC.......ph..C..p...ptlstt..........uTo.s.LppHL..........ptp.......................	1	185	394	653
+1007	PF01530	zf-C2HC		Zinc finger, C2HC type	Bateman A	anon	Swiss-Prot	Family	This is a DNA binding zinc finger domain.	25.00	25.00	26.10	27.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-7.84	0.72	-4.22	33	1621	2009-01-15 18:05:59	2003-04-07 12:59:11	13	44	89	6	769	1357	1	30.90	62	11.87	CHANGED	thpCPTPGCcGpGHlsG.pas....sHRSluGCPhu	............h+CPT.P.GCDGpGHloG.pas....oHR...SL..SGCPhA..	0	116	177	407
+1008	PF00097	zf-C3HC4		Zinc finger, C3HC4 type (RING finger)	Sonnhammer ELL, Vella Briffa B	anon	Swissprot_feature_table	Domain	The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid [1]. Many proteins containing a RING finger play a key role in the ubiquitination pathway [2].	21.00	20.70	21.00	20.70	20.90	20.60	hmmbuild  --amino -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.37	0.72	-4.30	35	9094	2012-10-03 15:03:13	2003-04-07 12:59:11	20	329	3245	29	3178	27732	1125	40.40	44	7.09	CHANGED	CslChchhppss................hhtCtHs.FCpsClpphhp........tptht..CPhC	...............................................CpIC...p...c.l..l...s..-Pl.......................................................pos.C......p........Hh....FC.+....s.....CIh.ctlc.............................hhssh.....C.PtC...................................	0	1053	1488	2303
+1009	PF00642	zf-CCCH		Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.40	0.72	-4.21	88	7686	2012-10-01 21:35:20	2003-04-07 12:59:11	19	244	456	18	4636	7265	193	26.00	35	7.49	CHANGED	hcpthCphatcsG..tCpaGspCpFtHsh	..........p.hCpha..h.c.G.....tC.paG.s.p.Cp..FtHs......	0	1486	2495	3614
+1010	PF00098	zf-CCHC		Zinc knuckle	Bateman A, Eddy SR	anon	Overington and HMM_iterative_training	Domain	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag  proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.	20.80	16.70	20.80	16.70	20.70	16.60	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.41	0.73	-6.48	0.73	-3.78	184	50986	2012-10-03 11:39:54	2003-04-07 12:59:11	18	692	722	56	6654	45194	253	17.90	58	7.29	CHANGED	tpCapCGp.GHhu+-Csp	....htCapCG.KEGHht+sCpt....	0	2202	3537	5115
+1011	PF02008	zf-CXXC		CXXC zinc finger domain	Iyer LM, Aravind L, Bateman A	anon	Bateman A	Domain	This domain contains eight conserved cysteine residues that bind to two zinc ions.  The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterised by two repeats [3], and shows a peculiar internal duplication in which the second unit is inserted into the first one [4]. Each of these units is  characterised by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been  identified by NMR [3]. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess  a mono-CXXC domain that is present in distinct chromatin proteins  [4]. Structural comparisons show that the mono-CXXC is homologous  to the structural-zinc binding domain of medium chain  dehydrogenases [4].	21.10	21.10	21.80	21.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.87	0.72	-4.15	31	1021	2012-10-08 21:21:50	2003-04-07 12:59:11	15	77	106	16	505	970	22	46.30	45	4.85	CHANGED	pshp+pp+.CGhCcuCpps-.CGpCssCpD...hhKaGGsspp+Q.pChhR+C	.........t.t++ppR.CGpCp.uCpps-sCGpCshCpD...hh.KF.G..Gssth.+Q.pCh.hRpC.........	0	110	148	279
+1012	PF01529	zf-DHHC		DHHC palmitoyltransferase	Bateman A	anon	Pfam-B_945 (release 4.0)	Family	This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.00	0.71	-11.65	0.71	-4.87	97	4432	2012-10-03 10:42:43	2003-04-07 12:59:11	15	126	347	0	2951	4268	82	169.10	23	40.72	CHANGED	hhsahhshhssPGhhspt.................................................................................................................................................................................................................................hhtss..tttptpaC.p...........Cphh.+PsRs+HCphCspClhchDHHCsWlssClGtpNa.+a.F....h.......hF...........lhhhslhhhhhhh.....hthhhhhphhtptphh.hhhh...........................................................................................................lhhhhhs........hhhhlhhshlhhh.........phh.hhh.ps...hT....ohEhhptt	...................................................................................................................................................................................................................................................................................................................................................................h...........Pu.......................................................................................................................................................................................................................................................................................................................................................tt..............thp...a.Cpp...............C..p........h.......h..+P.........s....R.u.+HC...p.....h..C..s......pCV..h.+h.D...H..H.....C.s..W.....l.s.NCl...G.............tp....Na..+a..F..h..........hF..................................lhh...h.s..l.h....s.h....h..h....h.h........h.s.h....h......h....h...h....t..h....h....t.....t....t.t...........t..h....h..h....................................................................................................................................................................................................................................................hhhhh.hs................hhh.hh.h...l.s...h....l..hhh...............phh.hlh..ps............T....ohE.h...t.......................................................................................................................................................................................	1	1087	1605	2335
+1013	PF04438	zf-HIT		HIT zinc finger	Bateman A	anon	Bateman A	Domain	This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein Swiss:P46973. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) Swiss:Q15649 that specifically interact with the ligand binding domain of the thyroid receptor.	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.11	0.72	-4.30	100	1073	2012-10-03 05:12:49	2003-04-07 12:59:11	11	21	308	3	734	1067	14	30.60	38	9.10	CHANGED	tpphCsl..Ctp.....u+YpCPpCsht........hCSLpCh+	..................hCsl...Csp.....u+Y.pCs+C.sht........hCSLpCh+.....	0	221	385	573
+1014	PF02891	zf-MIZ		MIZ/SP-RING zinc finger	Bateman A, Mistry J, Wood V	anon	Psi-blast Q9UN16	Domain	This domain has SUMO (small ubiquitin-like modifier) ligase activity and is involved in DNA repair and chromosome organisation [2][3].	22.20	22.20	22.30	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.07	0.72	-4.45	36	975	2012-10-03 15:03:13	2003-04-07 12:59:11	15	16	294	1	586	1031	4	50.20	45	7.21	CHANGED	lSLpCPlohpRlpl..PsRuptCpHlQCFDhtuaLphspptss....WpCPlCsps	............lSLhCP..ls...t.h.Rl.pl..PsRutsC.pHl.Q..C.FDh.phaLphNp..cp.so...........................WpC..PlCsK.t................	0	192	294	443
+1015	PF01753	zf-MYND		MYND finger	Bateman A	anon	Bateman A	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-9.03	0.72	-4.08	177	3934	2012-10-03 05:12:49	2003-04-07 12:59:11	13	252	370	26	2780	4039	204	41.10	35	7.26	CHANGED	C..shCtp.....................tshp..pC.spC...........p...ts....hYCSppCQptcW.t......t....H+p.C	...................................................Ct.Ctp...................................tshp.......pC..stC..............p......ts........hYC...u...ppCQ.p.tcW..t............t.......H.+p.C...................	0	1218	1661	2317
+1016	PF05020	zf-NPL4		NPL4 family, putative zinc binding region	Wood V	anon	Pfam-B_13681 (release 7.6)	Family	The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome [1]. This region of the protein contains possibly two zinc binding motifs (Bateman A pers. obs.). Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.	20.40	20.40	20.80	20.60	18.60	19.80	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.90	0.71	-4.55	22	277	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	241	0	198	293	0	135.90	48	23.39	CHANGED	pVpp.slDshL-KpDGhIpRp+.ophC..+HGsKGMC-YCsPL.PaDcpYhpEpp..IKHlSFHAYL+KlspspNK.t.GoSalsPLppPsaplphsCssG.H.PWPcGICoKCQPSAITLQpQpFRMVDHVEFtsssllspFlshWRpTGs	................................................................s.V.pstlDphLsKpDGpI.Rp+Dsp.h.C..+HGspGhCs.aCh.PL..-Pa.DtpYLp-pc..IKHhSFHuYlRKlsuus..sK.............Gp..hh....sLpp...sh+l+psC.s.......H.PW..P.cG.ICoKCQ....PSAITLppQpaRhVDplpFpsssllspFLsaWRpTG.....................	0	67	103	162
+1017	PF04810	zf-Sec23_Sec24		Sec23/Sec24 zinc finger	Bateman A	anon	Bateman A	Domain	COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.	23.10	23.10	23.10	23.70	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.35	0.72	-4.39	133	1393	2009-01-15 18:05:59	2003-04-07 12:59:11	10	29	324	26	939	1354	14	40.00	38	4.58	CHANGED	sPlRCp..pC+ualNPasphs...suppWtCshCtt.pNplPspY	...............PlRCp......pC+uYlNPa.sph.t.......pu+p..WtCshCtp.tN.plPspY......	0	313	517	760
+1018	PF02148	zf-UBP		Zn-finger in ubiquitin-hydrolases and other protein	Mian N, Bateman A	anon	IPR001607	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.77	0.72	-3.86	179	2273	2012-10-03 15:03:13	2003-04-07 12:59:11	14	45	510	19	1416	2222	31	68.20	29	11.39	CHANGED	C.....spCs............................s..ps..................lWl....CLp..CGpluCG.....R.p...........s..sHAhpHa.p.pss.....................................Hslslslsshp........l.aCYss..-shVp..s.ph	..................................................................................C.ptCt...................................sp....ts.......................lWh....CLp..CGpluCG.............R..........................p.sHAhpHh.p...psp...........................................................Hslslslpshp...............................l..aCYss..cp.Vhp..h..................................................................	0	429	703	1082
+1019	PF04704	Zfx_Zfy_act		Zfx / Zfy transcription activation region	Kerrison ND	anon	DOMO:DM04798;	Family	Zfx and Zfy are transcription factors implicated in mammalian sex  determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger  (Pfam:PF00096).  This region has been shown to activate transcription when fused to a GAL4 DNA binding domain [1].	25.00	25.00	25.30	25.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.01	0.70	-5.58	5	252	2009-01-15 18:05:59	2003-04-07 12:59:11	8	42	68	0	75	216	0	215.60	54	43.94	CHANGED	EsVlIEDVcCSDIL-EsDV.SEuVIIPEQVL-uDVA........EE-SLuphslPDplLTS-LlosololPEpVhsuEuVosss.GHlEpllpssVlttEIlsDPLstDlVSEEVLVADssSEAVIDA......SGlPl+ppDDD....KuNCEDYLMISLDD.uuKlDH-GuoslTMuA-uEpDs..SKlDGsuPEVIKVYIFKADu-ED.DlGGTlslVESEs-NcHtssVhDspsSuRlPREKMVYMsVsDSQQEEDDLssuEhsDpVYMEVIVGEEDAu.......stHEpQM-DSElpKTFhPlAWAAAYGNNo.DuIEsRNGTASAhLHIDESsGLsRlsKQKsKKRRRGEoRQYQ	..............tl...-sVps.-IhtEs.l..o-.....sVIhP-tlLt.s-Vs.........-.sL...t........c.lLsu-lhtt....s.........thP-pVhss-.hp...................................................hsp...-slhp...............................tlslp..p..p.................cssspDYLMI.ShD-.s.Kh.......s.hphtst.......t....p.pt.s.E.VIK.VYIFKA-st-D..-lGGT..lsES-.pssH....tlhs..s.p.Rh..REKMVYMsVpDSp.E-..-.-........................htpcpt...............................p.hpts........s....hhh.hs................u................Ns....ssl.Es+sssAuthLpIs-uhshs+lhKQKsKK..++Rs-s+QhQ................................................	0	3	9	28
+1020	PF02535	Zip		ZIP Zinc transporter	Bashton M, Bateman A	anon	Pfam-B_1189 (release 5.4) & Pfam-B_1903 (Release 7.5)	Family	The ZIP family consists of zinc transport proteins and many putative metal transporters.  The main contribution to this family is from  the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant [1].  Also found within this family are  C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.	28.30	28.30	28.30	28.30	28.20	28.20	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.02	0.70	-5.42	40	6416	2012-10-02 19:55:49	2003-04-07 12:59:11	17	54	2513	0	3060	5517	747	223.60	18	74.42	CHANGED	h.thhlhulhslhlsohhushhshhh.hhtt............................t..phhlphlhsFuuGllLusualHlLPcuhcshtpt.pht.............................................shsshhshhGhhhhhhl-phhphhhtt............................................................................t..t.....t..........t.t..............................................................................................................................t..htptptcpptpspppsppphtpthp.t....................uhllh...............huhslHslh-GLAlGsotsssp...shslhlAlhhHcl.cslGlsuhLlpushsptpshl...hshlhulssslGhslGlsl.........tustuthspull.uhoAGhhlYlull-llspthtpsp...........................h..lhphlsllhGhulMslls	.........................................................................................................................................................................................................................................h.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t................................................................sh.h.hh......................................................................hu.l.s..lHs..h....-G................l..A..l...u.....s........s.......h.t.....ss..................uhslhlu..l..h..h......Hp...hscuh..u.............ls......h...l...h..............t....s...........s....h...........s....t.....h............p.....s..hh.......hshh...u..l......s...................p.sl.G..sh........l.u.hhh.................................s......................h....s..............h...h....h.............s.................h..............h..........h..........u...h...sAGh..hl...al.s...h.-...l.l...s....p.th.t..tp......................................................hh....t..h.h..s.h....h....h.Ghhlhhh..s.............................................................................................................................................................................................	0	1027	1736	2521
+1021	PF00246	Peptidase_M14	Zn_carbOpept; 	Zinc carboxypeptidase	Finn RD, Bateman A	anon	Prosite & Pfam-B_4832 (Release 7.5)	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.07	0.70	-4.80	114	5755	2012-10-02 19:46:12	2003-04-07 12:59:11	19	114	1951	160	2797	5760	1277	247.20	18	49.68	CHANGED	lhsalcpls..tphPsls..phhsl.Gp.Sh-GRslhslclopt...................................tss+sslhlpushHupE..hluptsshhhl.....ppLlpt..............pstthppLlcphchallPshNPDGathst..p.......................................ttphWths........Rssst..............................GsDLNR.........N.....a........sht.h.........s.sspssssp.atu.ts.t..............pPEspulh.sa.l...pp...........tphthalslHuhuphhh.........aPas.............................hsh..........................shsssppp........hpplupthspshtp.ht.............t....a..phG.ssss............hY.ss.GuspD.....asa.phsh.......hsaThEltsps.......................hhhss.....spl..tsp-shtu	......................................................................................................s..t...h.h......p...h.....l..G.p.....o........h...........p........s......p.................l..h.lplst.....................................................................................................ttsc...t.l.h.l.u..shH.u.p.E..hhus..t..h.hh.hhl.................p.p.Lhpt...............................ts....th...p....t.ll..c..p..h.phh...llPsh..NP...DG.ht.hst...........................................................................................................R.ss.ss.....................................................................................Gh.DL.N.R.............................s....................a..........................s.............................................................................s......................................................psEspulh..ph...h....pp.........................................hphthhlshH..u...h.....s.thh...............h.a..s............................................................................................................................................t........................................s...t...........................h...h.t.......h....h.......................................................t......................................................t...p...............h.h.....th.................hthth................................................s.........................................................................................................................................................................................................................................................................................................	0	956	1446	2182
+1022	PF00100	Zona_pellucida	zona_pellucida; 	Zona pellucida-like domain	Sonnhammer ELL, Bateman A	anon	Swissprot_feature_table	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-12.48	0.70	-4.95	143	2880	2009-09-12 10:41:20	2003-04-07 12:59:11	18	163	237	17	1681	2596	0	221.40	16	41.22	CHANGED	pCsp.sph.........pltlpps.h.ts..............th.phsplpL.......pssp...........Cps.............hpsssshhhaphslss.........CGop.ppp...............hhYp..Nplhhphps..........................t.lhp.....hphtl.pChY........................ppshts..sh...................................h..thss...hs......s.sshp.........hphplhs..........................s..htp......................phss.h.lspsla.lc.....sphhs...........h.l........hlcsChA..Tss...s...s.spasll..ppGCs.pscshhsh.h...............htsphtcFp.hpsFpFs.........................spsplalcCplplCtssp......Cpt......Cstt	...................................................................................................................................................Ct..sth..l.lthp.....................th........phhh.............tt.t..................C.s...............t.st..t..h.h.h.h.ph.shpt............CGsh.thp.........................................t.........hhap....stlhh...t....ts....................................h.h........hthth.pCta........................................th...h.........................................................................................................s......................t.s.ht..............hphph..hp..............................st.................................t.sh.htlsp.lh...hp....h...hp..p..............s.h.l......................hlppChA.........sss............st.................phtll......tpG........Cs....tp.h.th........................................tsphhphp..hpsFpFs...........................pts.lahpCpltl.C.ttt.......C..........C...t.......................................................................................................	0	525	708	1302
+1023	PF01262	AlaDh_PNT_C	AlaDh_PNT; 	Alanine dehydrogenase/PNT, C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_4166 (release 6.6)	Domain	This family now also contains the lysine 2-oxoglutarate reductases. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.66	0.71	-4.69	96	5257	2012-10-10 17:06:42	2003-04-07 12:59:11	16	38	3489	97	1531	6780	5369	153.50	35	34.75	CHANGED	hpchttthshLhsussuVtP...A+VlllGuGVsGhsAhphAtsLGA.VsshDhpssphcpl-slhuphlps..................................hhsstttlpctltpsDllIsssLlPGpcAP+LlocchlppM+...................PGSVlVDlAl-pG.......GshEsocsss..................sshshpGVhhhu	....................................................................................h..p.tthhshhl.su...ss..s.V....s....P.....u+.V.h.l.l..G.u.G..VAGh....s..AhthAtu.L.G.A...........V....p.s.h......D..h..p......s.....p...t.h.c.p........l..c..s.........h..........h.........u........p..h.lps..................................................................................hh......u.....p......t......h.l...t..ptlp.cs..DllIsssLI.P...G..t.tAP+...L.....l.....Tc-M..Vps.MK.....................................sGSVlVDl.Ah.-..p..G...........GshE.h.o..c..ss.p....................................ss.h.h.t.pG.Vhhhu....................................................................................................................	2	518	968	1302
+1024	PF05222	AlaDh_PNT_N		Alanine dehydrogenase/PNT, N-terminal domain	Finn RD	anon	Manual 	Domain	This family now also contains the lysine 2-oxoglutarate reductases. 	29.50	29.50	29.80	29.50	29.30	29.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.44	0.71	-4.16	363	5191	2012-10-02 14:31:05	2003-04-07 12:59:11	10	33	3449	95	1522	3903	4047	132.80	37	29.97	CHANGED	GlP+E.hps...t...EpRVAlTPssVppL.....hpt.G.a..cVhVEsGAGh...uuuasDpsYptA...GAplss.ss.tp........lastu-lllKV+pP.........ssEhshl+pGphLhoaLahu...s.s.phsctLhppsloulAhEslsc.h..cu.slslLusMuplA	...........................GlP+E..hps..s...Ep.RVAhTPssVcpL...........lpt...G...a...pVhVEsu....A..G.....suuFsDp.sYtp.A.....GApIls...ss...c.......sas.u-lllKV+pP..................ssE.....hshl..........+p.....G.......thLho..aLa.A.......s.s.plhc.........tLh....p....p.........t........l..........o......s.lAhEsVsc...p........cup..sLshLusMuplA...........................	0	510	963	1296
+1025	PF05218	DUF713		Protein of unknown function (DUF713)	Moxon SJ, Pollington J	anon	Pfam-B_6651 (release 7.7)	Family	This family contains several proteins of unknown function from C.elegans. The GO annotation suggests that this protein is involved in nematode development and has a positive regulation on growth rate.	21.20	21.20	21.20	21.30	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.55	6	53	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	5	0	50	59	0	174.90	23	27.54	CHANGED	EELcchRpppKp+hhAFasClcLKhRFEEKEp-WuDWIpss.+pPIhRlhphFppF.ppht.....a++hsp-p.s-..lppEIhhlppclhshhsoLpphFppLppLppcap-sLFIKVLpKsIs-hAs+.......LhplhNsLsc...ssS+-.appLcshFppIssssIPoTopLR+ICKpsshSD.YpslcFPKl	...................................-hpph+pp.ptphth....hhpClhL+h+FEE+EccWucWlpsh.RpslsplhppahpFppphp..........hpc.hsp.c..cppp.....l.p.Eht.htpplhsshstlppsappLcpLpppasDtlFl+lL......Kslsphusp..................Lhplhptltph.....thspp....hp..pLcphhtplcs.ppIPoTspL+phspss.p.p-.Ypslp.s..h.....	1	9	9	50
+1026	PF05210	Sprouty		Sprouty protein (Spry)	Moxon SJ	anon	Pfam-B_6527 (release 7.7)	Family	This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [1]. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice [2].	25.00	25.00	25.40	25.40	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.29	0.72	-11.13	0.72	-4.04	18	429	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	86	0	238	353	0	107.50	48	29.34	CHANGED	+sRCt.C...RsL.Sphhss+.shCs.....ucsslcpsoChsCsculhYHChsDsEG-........huDpPCSCs.......cspsCsRWhuLuuLSLhlPCLhCYhPhRuCh+huptC.......GC..Ct	.................+s+Ch.C...........Rsh.sp..ss+.shCp......scsslchsoCMhCscuhhYHCh.s.DsEG-............................huD.PCSCs........................ps+hC......hRWhuhuuLSlhlPCLhCYhPh+uCh+hsptC.......GC..Ct....................	0	32	51	123
+1027	PF05216	UNC-50		UNC-50 family	Moxon SJ, Studholme DJ, Wood V	anon	Pfam-B_6607 (release 7.7)	Family	Gmh1p (Swiss:P36125) from S. cerevisiae is located in the Golgi membrane and interacts with ARF exchange factors [1].	21.10	21.10	35.20	28.40	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.58	0.70	-5.16	24	272	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	239	0	184	268	3	215.90	38	82.36	CHANGED	ssph.chhRRlFK.hppMDFEhAhWpMhpLhhsP++VYRshhY+KQ.....TKspaARDDPuFllLhshhLslouluauls.Ys..uhhp............hlphhlhhVhlDFlhsGlllATlhWhlsN+.aLp..........................hspsscpplEWuYsFDVHCNuFhPhallLYllQahLlPllh...ppsaluhhlGNoLahhulsYYhYlTFlGYssLPFL..................cssphlLh.Plsllhllallul.......hGaNlsthhhphYht	...................t.ph.pahRRLh+...hpQMDFEhAhWpMhaLh.h.sPp+VY+shhY+....KQ...........................TKspWARDDPAFllLlshhLslooluauhs.hs...uhhp............h..lphllhhlhlDhlhsGlllATlhWhlsN+.aht.................................hppstctcVEWu.......YsFDVHhNuF...aPhhlhLahlQ.hhhh.s....hlh.....tp.........s.........aluhhlGNoLahhAluYYhYlTFLGYss.LPFL...................cpT.p.hlLh..Phhh......lhll.ahl.s.l......hhG.aNhst.hh.hY...................	0	69	102	153
+1028	PF00702	Hydrolase		haloacid dehalogenase-like hydrolase	Bateman A	anon	Pfam-B_566 (release 2.1)	Domain	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null --hand HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.66	0.70	-3.93	239	27368	2012-10-03 04:19:28	2003-04-07 12:59:11	21	179	5134	203	8521	48772	5819	255.00	26	31.25	CHANGED	hcsllFDh.sGTL..hpsp.hl.................................................................................ttthhphh..tph........shthh.http.............................................................................................................sttphhpphhtt...h.tt.hhttt..................................httttthhhhh...................................................................................................................................................................................tthhthhthtstlhs......s.........stpslpp..........L+pt........uh....plsllo.s.....s....hpshtpths..l............................s.hhhuph...................pP.psc..h...tthhcp......lt................p.t........p....shhlGDuh.sDh.uhttAs	...............................................................................................................................................................................................................................................................................................................................................................................................sslshDKT..G....TL.....T.p.s..c...hplt.....................................................................................................ht...........................................ths.pp...p...h..h...p..hs...........ssh........p.....t......h.......s......p.....p....P........h.....u...p..u......l....h...t..h....s..p..t.......t...........................................................hp.t.h..t..t..h..........s...h...s..h..t....s.t.h.pst.......................................................................................hh..........us....p.h.h...t..p.t.s...hp......................t........t.............................................ttt.s.t..s.s.h.h.hs..................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................s...h.p.h..l..G..l.l...u...l..t......D....s....l...+..s................s..............................s..t..p..u....l...p.p...................L.+.p.t...........................................Gl..................c.s.h.M..l.T...G.................D.s..t...t...T...A...p...u...I..A..p...p...l..G..l..........................................................................................................................................................sc.....l.hAcl..........................................................................................................hP..cc..K...........hpl.lcp.............L.p.t.....................................................psp.....h..................VAM.......sG..D.Gl..ND...A.PALtpAD..........................................................................................................................	0	2722	5262	7124
+1029	PF04227	Indigoidine_A		Indigoidine synthase A like protein	Kerrison ND, Finn RD	anon	COG2313	Family	Indigoidine is a blue pigment synthesised by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown [1]. The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.	25.00	25.00	30.30	25.00	20.20	21.30	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.78	0.70	-5.19	90	1192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	1117	6	398	842	476	280.60	54	79.09	CHANGED	sEVppALssu.c.PVVALESTIIoHGMPYPpNl-sAppVEphlRcsGAVPATIAllsGcl+VGLsp--LEtLAp.....s.ps..lhKlSRRDlshslApsts.....GATTVAATMlhAphAGIcVFATGGIGGVHR.....G..A....EpoaDISADLpELu+TsVsVVsAGsKSILDlstTLEhLETpGVPVluY.....to-......chPAFaoRpSGhpsshcl-osp-lAphhcs+hp...LuLpu.GhllANPlPc-ttlstphlsshIppAlt-AcppGI..sGKslTPFLLs+ltElTpGcSLpuNIALVpNNAclAAcIAhsl	.............................EVppAl..p..sp..pPVVALESTIISHGMPaPpNspsAhpVEphlRp...............pGA...lPATIA.II.sGhh...+...lGLspE-lEhLup...............p...cs....VsKVSRR....DLs.hllA.....t.....tp...s.................GATTVAuTMIhA.shA...........GIcVFuTGGIGG..VHR....................G..AEp.....ThD.ISADLpE.LupTs.VsVVCAGAKSILDlshThEYL.............ETh......GVPVlGY.......pTc..........phPAFasRp...S..u.....hclsh..pl-osp-lAchh...ts+hp...h.....s...L.p.G.G.lll.A.NPIPc.paAhsc.phIsssIspAltEA-........pp.Gl..p..GK-sTPFLLu+lsElTsGcSLpu..............NIpLVhNNAhLAucIAht...................................................................................................	0	144	246	340
+1030	PF04613	LpxD		UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD  	Kerrison ND	anon	DOMO:DM04521;	Family	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyses an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein] [1]. Members of this family also contain a hexapeptide repeat (Pfam:PF00132).  This family constitutes the non-repeating region of LPXD proteins.	22.40	22.40	22.70	22.40	22.00	22.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.20	0.72	-4.44	90	2398	2009-01-15 18:05:59	2003-04-07 12:59:11	9	36	2248	13	574	1707	1557	71.20	31	20.84	CHANGED	sshtlpulAsLppAsssploFls.st..KYt.ptLpsopAuAlllstc......tp........stshshLlspsPYluaAplsphh	.............shhlsulAslpp..A..psuploFls..Ns.....KYp.cp.....Ls.p.opAuA.Vllspc.......s.............hs.s.ps.shLll.c.sPYlsaA+luphh.............	0	177	363	480
+1031	PF00244	14-3-3		14-3-3 protein	Finn RD	anon	Prosite	Domain	\N	21.40	21.40	21.40	22.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.50	0.70	-5.28	85	2097	2009-01-15 18:05:59	2003-04-07 12:59:11	15	15	551	104	918	1919	23	196.20	57	83.35	CHANGED	R-chV..ahAKLAEQ.AER.Y....--MlptMKplsph............tsc.LosEERNLLSVAYKNVlGuR.RuoWRll..SSIEQK-..csc...........................ppphphl+pYRpKlEpELsplCs-lLsLLDppLlPs..........u.........s...ssE.S+VFYhKMKGDYYRYlAEas.su........-c+c.csscpuhpAYppAp-lAp...pp..LssTHPIRLGLALNFSVFYYEIhNsPccACpLAKpAFD-AIu-LDs..LsE.-SYKDSTL.IMQLLRDNLTLWTS-tpscp	..................................................................pp.l.hA+LAEQ...A.ER.Y.................--Mst.MctVsp.............s.EL...osE..ERNLLSVAYKNV....lGuR.RuSWRll..SSIEQKpcsp.....................................-pphphh+..........pYRpKlEpELpplCp.s.lL..p.lLDpaLIss...................u.................s.....ssE..SKV....F.YhKM..........KGDYa.RYLAEht.....sG.......................................s.cR...p........ps.s-po.pA..Y..pp.....A.-lAp....sc.....h...PTHPIRLGLALNF.S.V.F.YYEIL..NuP.-+..ACp.LAK.p...A...FD-AIA.ELDo..L...s.E....-...S..Y...K.DS.TL.IMQLLRDNLT.LWTS-.tt..t.............................................................	0	308	472	682
+1032	PF02826	2-Hacid_dh_C	2-Hacid_DH_C; 	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.91	0.71	-5.12	161	20266	2012-10-10 17:06:42	2003-04-07 12:59:11	14	74	4565	208	5776	22821	13988	171.60	30	48.83	CHANGED	luhhLuhsRpl...hphppth....+pG....pW..........t...thhuh....clpG+TlGIlGhGpIGptlAchhp.uFGh.cllsasht.....t...........pthsh.phs.sl-cllppuDhlolpsP.loscTcpllstctlstMKssu.....hlINsuRGsllDcpALlcALcsGpluuAuLDVappE...........Phs....ts........p...sL....hp..hsN.....lllTPHlu	..................................................................................uhhlshhRph.....t...h...t.t.th............c.p.s.....pW............................t......t.hhuh..........cl...p......G.+...T...l.Gll.G.h.G.p.....I...Gp..t..............l.A....p..h.hp...ua..G.h....p.....l...l..h..a..s..h...................hp...............t......................tp..s.......h.......p......h......s.......s.....L.......-......c.....L..............l.....p....p.......u.....D...l...l.o...l...p.s..P....h........s.......s........p...................T.c..............p....l..l.....s...t....p..................t....l.s...t.M...K.s.....s..u...................hll.N...s..u..R...G....s.l.l.D.p.p.AL.l....pAL.....c....s.....G........c....l.t..u....A.u.l.DVa.p.p..E......................................P.hs.......t.s......................p.......s.L................hp.....h.s.N.............l.ll.TPHlu.............................................................................	0	1662	3388	4776
+1033	PF02834	LigT_PEase	2_5_ligase; 2_5_RNA_ligase;	LigT like Phosphoesterase	Bateman A, Mazumder R, Anantharaman V	anon	Bateman A	Family	Members of this family are bacterial and archaeal RNA ligases that are able to ligate tRNA half molecules containing 2',3'-cyclic phosphate and 5' hydroxyl termini to products containing the 2',5' phosphodiester linkage. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family. The structure of a related protein is known [1]. They belong to the 2H phosphoesterase superfamily [2]. They share a common active site, characterised by two conserved histidines, with vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.03	0.72	-4.00	107	1248	2012-10-03 21:31:47	2003-04-07 12:59:11	11	3	1026	8	425	2631	248	80.60	31	52.39	CHANGED	ls..spph.ppltpltpplc....thsh+h....ct.s.HlTLthlt.phs....pppls...plhpthtph..t...h.lplpthuhass...tspsla	.....................................tlPsphppplhp.hp..ssh.h............s.....tu..s...+.V......tspNhHlTLu.FLG.-ls...........scc.c..........sltp.h.....h..u...c.....l................c...p..ss..F..s...l.pLc.shGtah....csRVlW............................................	0	167	289	360
+1034	PF03475	3-alpha		3-alpha domain	Aravind L, Anantharaman V	anon	Aravind L, Anantharaman V	Domain	This small triple helical domain has been predicted to assume a topology similar to helix-turn-helix domains. These domains are found at the C-terminus of proteins related to Swiss:P32157.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.87	0.72	-4.24	49	1443	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	1316	6	193	768	20	46.50	31	19.76	CHANGED	cloVtchhplhascphs..hptlccllsh.ssLutoW+pphp+Rlpptps	.................cloVpcssp.lhap......hs......p-tlccl...Lss.ssL.SsoWpcphpKRhtpt..........	0	52	97	146
+1035	PF01612	DNA_pol_A_exo1	3_5_exonuclease; 3_5_exonuc;	3'-5' exonuclease	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_659 (release 4.1)	Domain	This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D).  Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction [4,5].  The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein [3]. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.15	0.71	-4.79	27	6914	2012-10-03 01:22:09	2003-04-07 12:59:11	15	92	3529	32	2350	6043	5677	173.20	23	27.78	CHANGED	hphlpsppthpchhppltstt......slAlDTEppshph..h.p.hstllQlpst.....ptsalhsshthts..........hphLptllpssphhKlhasschDhthltp........aulhhpsla-s..lAstllshtpt..........auLssLspphls...hthspppttucap.....tcslhcpth........tYAutDshhhlp..lhppLpp.lp	.................................................................................................................l.s.tth.tt.hh.t.t.l..pt.ts............hlAlD...T.....E....t...........s.......s.............h.....p..s........................h....p.............h....h....h.......hl.pltss...................pss.h.l.......s..s....h..s..h...t.s..................................................hp..Lp..s.lL..p..s...s.s..l.h.....K......lh..as.h.c......D.hth.ltp............................................h.G..l...t...h..p.....s.....l...h...........Ds...........l...t...u...h..l..h..s.h..stt....................................................huh.s.....s...L..s...p..c.....h.ls.........hs...l.............s...h..p....p......t.....u..cht...............................tcsh...c.pth..............................pY.AAt..Ds.hhhp...lhptlh.pl.............................................................................................	0	797	1441	1966
+1036	PF00803	3A		3A/RNA2 movement protein family	Bateman A	anon	Pfam-B_1054 (release 2.1) & Pfam-B_6332 (release 7.5)	Family	This family includes movement proteins from various viruses. The 3A protein is found in bromoviruses and Cucumoviruses. The genome of these viruses contain 3 RNA segments.  The third segment (RNA 3) contains two proteins, the coat protein and the 3A protein. The function of the 3A protein is uncertain but has been shown to be involved in cell-to- cell movement of the virus [1]. The family also includes movement proteins from Dianthoviruses.	25.00	25.00	35.30	33.40	22.10	17.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.29	0.70	-5.30	27	894	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	89	0	0	507	0	209.50	48	84.13	CHANGED	sppstusspppLlptlhu.ps.hpthtpcsshuphp.hpussphshh......sLlPssstsplsshhp......opacssphsosG...................hhpls+lllhlsPTls.sssGpVpltLhDsshss....hpslst.pphplphsss...PtlhsFhssYshPhpp.s...........pRCFtlshphsuhh..spusSshSlhhhWptphsspspsYp.pssthh.lp..hpRt.thpshsthpp...alcush...spssstthlhspshsh	....................s..plutcsuss.lsp.aSsss.chsl.spthDsu+t+hhhsspusSsh...........SlsEucuaDl.ARhlV-pspHlSNWKNDhhVGNGpppsshsIpIhPTWsSp+pYMhISRlVIWVsPTIP.sssGcLsVuLlDPNhPo.........-.cpVIL+sQGol.hDPhCFlFYLNWSIPKhsNTP............csChQL..pLhCs..pcY...thssohuSlh..WptpFsspsts.pp.ss.........................................................................	0	0	0	0
+1037	PF02829	3H		3H domain	Bateman A	anon	[1]	Family	This domain is predicted to be a small molecule binding domain, based on its occurrence with other domains [1]. The domain is named after its three conserved histidine residues.	25.00	25.00	30.00	44.50	21.30	19.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.17	0.72	-3.97	57	945	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	913	1	147	544	7	98.00	42	55.62	CHANGED	lssp..H.ss-chc-ELphIVc.pGGplhDVhl-HP.lYG.clpupl.tlpscp-VppFlcplpps.cup.....LppLTs.GlHhHTlpAssccsl-pIpctLcctGaLl	...............htsp.H..psEchcpELphI.VD.pGGpVp.sVhl-HPlYG..-lpu.L.plpsRcDVpcFlcplpps.pup......LSpLTc.G.lHhHplcA-oppsLctIccALcctGaLl...................	0	62	104	124
+1038	PF00725	3HCDH		3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_743 (release 2.1)	Domain	This family also includes lambda crystallin. Some proteins include two copies of this domain.	21.00	21.00	21.00	21.00	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.19	0.72	-3.59	77	10901	2012-10-02 19:36:46	2003-04-07 12:59:11	17	35	3006	55	3264	9099	4385	93.80	27	23.85	CHANGED	GFlsNRllhshhsEAhpllpcG.Assc-lDpshchthGaP.MGPhpLsDhlGlDsshplhp.......hhtpths-p...thp.s.lhcphscsGchGcKoGcGFYpY	.............................................GFlsNRl.l.h..s.h.l.s.EA.h.p.h.l.p...........-......G.......h..u.s...s.p.c......l......Dtsh.p.hs..h...Ga...P...h...G...Php..h.h...D...hl...G...l.Dsshp.l.hp...........................hhtpt.hspp............hp..s..s.....hl.pph.h....p.t.sh.h...GpKs.s..t..Gaa..............................................................	0	922	1912	2683
+1039	PF02737	3HCDH_N		3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_743 (release 2.1)	Domain	This family also includes lambda crystallin.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.95	0.71	-4.63	74	8383	2012-10-10 17:06:42	2003-04-07 12:59:11	13	46	3107	48	2683	14660	8387	177.00	33	34.30	CHANGED	pVuVlGA.GsMGsGIAtlhAps.GhpVslhDh......spptlpcuhptlpp...thtphhpcGphs........ttphsthhsplp..hsschsshs.su.DlVlEAVsEslclKpclFtcl-tls.tscsIlAoNTSulsloclupshp.cPc+..hlGhHFF.N.Ps.lM.LVElltutpTuscslspshshscpl.GKtPVhV.pDs	....................................luVl..G.u.G.h..M........GuG..I.......A..h.......h..h........A....t..........t.....G....h..s......Vh.lhDh.................st...p...s....l...s.......p...u........h...s...t...l.tp...........L.p..c..t....l..p..+...u...+..ls.................................t.t.p.hs..t..h..l..u....p..l.s..........s.......s...s.......c..........h.....s....s......h......s......c......s..........D.......l.V...............I........E.........A......V........s......E......s.......h......c...l.K......p...pla.t..c..l-.p..h.s.....t..........s.c......s..l..lASN.TSolsIs.pl..A.............s....s.......s.............p.......+........P.......cc..............hlGhHF..F..N...Ps...hM.LVEl.lt.........ut......p.Tusps.l.s.......pshsh.s.p.p.h..GKsslhl.pD.........................................................................................................................	0	802	1633	2233
+1040	PF02446	Glyco_hydro_77	4A_glucanotrans; 4a_glucanotrans; 	4-alpha-glucanotransferase	Bateman A	anon	Pfam-B_1924 (release 5.4)	Family	These enzymes EC:2.4.1.25 transfer a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan [1].	25.00	25.00	26.80	25.60	23.20	24.80	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.45	0.70	-5.93	14	3053	2012-10-03 05:44:19	2003-04-07 12:59:11	12	17	2557	11	694	2467	761	483.60	30	78.89	CHANGED	lplhSL.oc...GIG-hGppAh.hlDahpcsG...hplhQlLPlssou.ssu.......PYsShSuhAhNslalclpsLs-tthlc............hpchpphpstspVcYsplhthKhshL+csacthpppt...pppsFppFtccp...phWLcsaAhF..hAlK-phss......hsWspW.....pshptpctpslpchpcphp-clpFataLQalhapQhppl+saApp..psltIhGDlPIhluccSuDVWs..chFphs.......tsuGsPPDhFsppGQtWu.PlYsactLpccsapWWhcRlctshphasllRIDHhhGFhphW.lPt.................ucppAtsGcahhsPG...................................................................cclhshlhpths................................................................ph.lIuEDLGslss-VcthhcphulsGh+llpFshs.-spsshlPpsh...ptpsVshsuTHDssTltuWacst.....................pccpphhtpaLs......ph.pcthptsll+hshposuhhtIh.hpD....hLuLss-........tRhNhPuTssp..NWsaRlpss.......-.hssppphhphltplh	....................................................................................................................hplhoL.op...t.....G.I.GD.Fup.th..hl-.h.ht.c.sG.....htl..lhslhss.s..t.su..........................P.Yp.s...SthhhNshaIc.l..p..t....l...-.h..t.hhptt................................t....p..t.....h.....p.....t..h.....p.....s.....s...p......h.lD.Ys.tl..hthKh.s.hL..c.hsa.pta...........t....p....p..........s.............p...........t........s........F...ppF..ht..pp....................tth..Lts.aAha.............sl.+.....c..p.htt.............................h..s..W.....t.Ws........p.......th.......pp....hc.............s............s....sl.....pph......p.p..p..h.........t.-.clpaahalQahhhpQhtth..pp..hApp..hsItlhsDlslhVutsuu-sWsp.c.haths....................................sssG.sPP......D.ha.......u.s.tGQpWG..Psa..s.c....h....hp...t..pu.............Yp.alchl.Rtshphhs...........s..........lRIDHhhGhhchWh.IPt...............................up..s.AtpGt.a.lphPs.............................................................................................................................................................................pclhsh.lthE..t.........................................................................................................................p.h.lIuEDLGs..l..s..sp....lhthhcptGl.uh+lL..Ft..h........................p.......p......p.........s...........h......h....h....P..p.ta.............stpulshsuTHD.sTl...tG.aapst..c.................................................................................pp..ppph..h......t.t......h...l..s............................t..h.............t....p.......s.....h....t....p....s..h...l.....p...s.h...h....s....o......h.....sp.h..h...h.h...h..tD......................lLulp.p.........................t.hNhPGTsst...NWph+hsts.......p.h.t.tth........t....................................................................................................................................................................................	0	231	453	586
+1041	PF01812	5-FTHF_cyc-lig		5-formyltetrahydrofolate cyclo-ligase family	Bashton M, Bateman A	anon	Pfam-B_1555 (release 4.2)	Family	5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase EC:6.3.3.2 catalyses the interchange of 5-formyltetrahydrofolate  (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+ [1]. 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin [2].	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.10	0.71	-4.52	24	4810	2012-10-04 00:26:15	2003-04-07 12:59:11	15	19	4472	16	1259	3577	1998	177.40	26	87.98	CHANGED	KppLRcphht.thctlspcphtptsptltp+lhshhthppu.ppl........uhYlsh.ssEhshp..tlhpphhptschlhhPhhp.ps..................................s.h.ps.ht........lhpPhpthth..s..........plDllllPulAFD.ppGhRLGhGtGaYDRhLuphpt.....p.htlulshcpQhhs..plPt-....aDhslchllss	...................................................................................KpplRpthhp..phps....l.....s.....p.....p..p...p...p....t.....s..p.....t....l.t.p...p....l....h...s....h...........t...h.......t....p....A.....p......s...l.........................................................uhals.h..s..s..El...s...Tp...........sl..l..c..p...h..h........p...........p........G.........K.....p.....l..h..l.Phh.ps.ts..................................................................................h...h...h...t...h.p..s....t.s....t...l....h.p.s..t.a.s................................lhEP.t.ts.h.t.h...................................plD.llllPslA.....F....D...c.......p...G...h.....RlGhGGGaY..D....RhL..s..phpt..........................hs.........l....u.ls.a...s..t..........Qhl........c........p..........l....P....s...Es.........a.Dl..slstllT.....................................................	1	390	782	1045
+1042	PF02739	5_3_exonuc_N		5'-3' exonuclease, N-terminal resolvase-like domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_716 (release 3.0)	Domain	\N	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.04	0.71	-4.88	25	6210	2012-10-03 20:43:45	2003-04-07 12:59:11	11	20	4577	17	1278	4680	3819	164.00	35	23.04	CHANGED	ppLlLlDGpulsaRAaFAhs......LpsspG.sTs.AlaGFhphLhpllccppPsalllsFDutsp..TFRcchYtcYKusR............spsP--LhsQlshl+EllctlGIshlEhsGaEADDlIGTLAcpAppc..GhcVhIlouD+DllQLls-...pVtlhps........tchphhss-pVhEK.a	...................................................................................LlLlDGpuhhaRAaaAhs...................h..p..s.s..p.G.........T.....s......Alh.G........h........hp....hLt....p...l...l.....p.....c.........................p.......P.....o.........H....hs.........VsF.D.....................s.t................t...............p......TFR..............p-h.as.cYKusR........................................s.s.hP..-....-........L......p......t......Q....h......s....h..........l.......+........ch..l....c....u......h........G....l..........s.h......h.p.h.....s.GhEADDlIGTL.Ap..p..u...p...p.p.......G.....h.......p.V.h.I.loGDKDhhQLlsc......p....l.t..lh.pp...........hp...phh.s.ptlhc+.....................................	0	413	828	1081
+1043	PF01367	5_3_exonuc	5_3_exonuclease; 	5'-3' exonuclease, C-terminal SAM fold	Bateman A, Griffiths-Jones SR	anon	Pfam-B_716 (release 3.0)	Domain	\N	40.00	40.00	40.30	40.00	38.60	39.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.20	0.72	-3.78	27	6018	2012-10-01 19:52:02	2003-04-07 12:59:11	15	19	4488	11	1254	4486	2458	100.70	36	13.83	CHANGED	lsPpQ....hhDhtALhGDsSDNIPGVtGIG-KTAhpLLpcaGSl-slhp..Nl-plps.ph+......ctLpspc-sshhScpLuslcsDlslplsh-sh.......thps.stpplhp	.........lsPpQ....llDhhuLhGDoSDNlPG....V....sGl....GpKTAhpLLppa.G.ol-slhp.....pl..-....p....lp...s.......+.h+...........................cpL..p..p..s..p..-.............t..AhL..S+..pLAo.lps.Dl...s...l...s..h...s.h...cpl.......thp..t......t..................................................	0	404	813	1059
+1044	PF03491	5HT_transporter		Serotonin (5-HT) neurotransmitter transporter, N-terminus	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.30	20.30	20.90	22.20	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.17	0.72	-3.84	3	54	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	34	0	20	41	0	39.10	70	7.22	CHANGED	ENGVLQKuVPTPADKVESGQISNGYSAVPSTGAGDDAcHSlP	.............ENGVL..QKsVPsPGDKsESGQISNGYS....AV....PSPGAGDDspHSIP.............	0	1	2	4
+1045	PF02096	60KD_IMP		60Kd inner membrane protein	Mian N, Bateman A	anon	IPR001708	Family	\N	25.40	25.40	25.50	25.50	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.46	0.71	-4.65	147	6198	2012-10-01 21:53:17	2003-04-07 12:59:11	15	26	4682	0	1609	4484	3134	199.40	31	48.09	CHANGED	s.saG..luIIllTlll+.lllhPLshpph+Sh....t+Mpp....lp..Pclp....clpc..+a...............ps.ctpc.....hppEhhcLYccpslNPh...uGCL.PhLlQhPlhhuLatslpp...............................................................hp.....l...........pp.............ssFh.........................W......lpcL...........ussD............................................hhlLPllhulshhlpppl........s....................pst......pt+hhhh...hh.Plhhh.....hhhhphP..uGLsLYWhssslhslhQphhl.pphht	............................................................................................................................................saGhuIIl.lTl.ll..R...hll.h.P..L....sh.tp....hpoh..................tK.M.pt......l..p......Pclp.................tlp.c+a...........................................t-..-pp+...................hp..p....E...h...hp...LYK......c..p......s.l..N..Ph......uG..C....L.....PlL.l..Qh..Pl...ah.ALY.hslhp............................................................................................................................................shp...............l.............pp..................usFh.................................W.............l..cL............ussD.......................................................................................s.hh.lLPl.lh..uls.h.alpp.t.l......................................s..................................s.ps..htphhhh.................hh.Pl..hhh.....hhh.....h........hP....................uGLsLYWlluN.......lhsllQphllpp...t............................................................................................	1	548	1016	1354
+1046	PF00428	Ribosomal_60s	60s_ribosomal;	60s Acidic ribosomal protein	Finn RD	anon	Pfam-B_151 (release 1.0)	Family	This family includes archaebacterial L12, eukaryotic P0, P1 and P2.	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.32	0.72	-3.59	107	2118	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	646	27	1183	2032	138	88.10	32	53.35	CHANGED	psossslppllpuush.plcshthphhhptlp..uc.slc-llsssttt.....................uuuuusAAuuuuuuuusAspcpccEEcc...........EpD-..DMG.hu...LF	......................................................................sotsslppll.......puush.pl-s.hthp..h..h.......hptlp..uc.slc-llsssssths............................................uuuuAs.Au.u...u...u...u.u.u...u.A......s.s.sp...E.cccEEcc...........E..EoD-......DM..G..FG...LF.......................	0	390	647	956
+1047	PF01591	6PF2K		6-phosphofructo-2-kinase	Bateman A	anon	Pfam-B_717 (release 4.1)	Domain	This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis [1]. This enzyme contains a P-loop motif.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.39	0.70	-5.28	11	1160	2012-10-05 12:31:08	2003-04-07 12:59:11	13	22	311	13	696	1195	96	194.90	37	39.97	CHANGED	tcsssssp.pss.hhIVMVGLPARGKTaISpKLTRYLs....WlGhsTKVFNVGpYRRpssps........pshcFFcs-NpEuhclRcpsAhsALcDlhsaLscEsGpVAlFDATNTTRERRchIhphsccps........hKshFlESlCsD.plItpNIpplphuSPDYtspss-c.AhcDFh+RIcsYctsYEPLD.-ppDcsLSaIKlls.lGpphllNpVpsalpSRlVYYLMNlHlpP	...................t........pss.hhllMV.GLPARG......Koal......u..pK...LsR..YLs.................WlG..h.o.+..l.....FN..lG.p..Y.R.R.pts.tt..............................................ps..h...p...F.F.p.ss..Nt..c.uh...p.lR...cphAhtslc..........Dlhp...al............p....p............p............s.....G..........p...........lu..l.................a......DATNoT.+cRRphlhp.h.h.p.p..p.s........................................h..c..shFlESlCsD....pllttNI.h.ph.p.h.s.s.........PD....................Yhs......h.s...cp...AhpDFhpRIppYct.....s.....Ypsl...s..................-.....p.....p..l.............s.....aIKhhs...sGpp.h.hl.s.p.l.p..salpo+lVaYLhNl+lp........................................................................	0	187	351	557
+1048	PF00393	6PGD		6-phosphogluconate dehydrogenase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase.\	\	 The domain contains two structural repeats of 5 helices each.	20.40	20.40	20.80	20.60	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.91	0.70	-5.20	58	5458	2012-10-02 19:36:47	2003-04-07 12:59:11	14	19	3935	36	1173	4118	977	231.40	44	59.81	CHANGED	GHaVKMVHNGIEYGDMQLIuEAYplLKpsLGLoscEluclFpcWN.pG-LcSYLIEITucILpt+D.....ps.G..p......sLVDhILDpAGQKGTG+WTs.sAL-lGlPlshIsEAVhARhLSuhKcERltAS+.hLsG...sp.....sthss-+ppal-sl+pALYsSKIsSYAQGFtllptASc-asWsLshupIApIWRGGCIIRutF.LscIpcAappsssLsNLLlssaFpptlpptpsuaRclVu.hAsptGlPlPuhSoALuYaDuYRsspLP.ANLlQAQRDaFGAHTYcRh..........D+pGs..FHTpWs	................................GHaVKMVHNGI.EYGDMQLIuE..uYplh..+..p..s....h..s..h......s.....sc.......-.......huphFpcWN...pG.-....L.s.S.aLl-IT...tclh.ptcD.......pp..u..p.....................ll.-h.I......h.....D.....p.....A.....u......p.....KGTGKWTs.sAL-lGhPlslIs.EuVFARhlSu.h.K.p.p.Rht..A.sp..h.h.t.....s................scctthl.cpl+pALahuKlhuYAQGF..hptAu.pp...tWs.lshuplA.laR.sGCIIRu.......F.Ltp.I.pp.Aa.tp....s....s....t.l.................s.Llhs.hFtth..h..tp.h........tuhR.....plls.h............u............hp.G...........lP...........hPshu.uu.l.s.a.aD.uhp.st.L.P..AsLlQ.......AQRDaFGuHsaphh.........s....t.........hH...W...............................................................	0	355	715	977
+1049	PF02495	7kD_coat		7kD viral coat protein	Mian N, Bateman A	anon	Pfam-B_2886 (release 5.4)	Family	This family consists of a 7kD coat protein from carlavirus  and potexvirus [1].	21.10	21.10	21.40	23.50	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.89	0.72	-4.52	61	349	2009-09-10 16:31:06	2003-04-07 12:59:11	12	1	114	0	1	324	0	58.80	27	70.57	CHANGED	h....hhhhlullssllslhhl.....psssssChllITGESlplpu..C..hsschlchl.psL+shst	.......h..lhhhlslls.sllslhhl........ssppspCpllIoGculhIss..C.t.os-hlchl..shpPhp.s........	0	1	1	1
+1050	PF02294	7kD_DNA_binding		7kD DNA-binding domain	Mian N, Bateman A	anon	Pfam-B_8148 (release 5.2)	Domain	This family contains members of the hyper-thermophilic archaebacterium  7kD DNA-binding/endoribonuclease P2 family. There are five 7kD DNA-binding proteins, 7a-7e, found as monomers in the cell. Protein 7e shows the  tightest DNA-binding ability.	25.00	25.00	119.50	119.30	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.11	0.72	-4.29	2	33	2012-10-02 16:56:36	2003-04-07 12:59:11	13	1	18	30	10	32	0	61.50	90	96.62	CHANGED	ApV+FKYKGEEKpVDhSKIKKVWRVGKMlSFTYD-.sGKTGRGAVSEKDAPKELhpMLt+tc	s.TVKFKYKGEEKEVDhSKIKKVWRVGKMISFTYDEGGGKTGRGAVSEKDAPKELLQMLEKQK.	0	2	2	9
+1051	PF00001	7tm_1		7 transmembrane receptor (rhodopsin family)	Sonnhammer ELL	anon	Prosite	Family	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.81	0.70	-5.25	64	42866	2012-10-03 04:04:29	2003-04-07 12:59:11	16	290	7772	141	17156	63287	11	225.60	18	72.53	CHANGED	GNslVlhslhtp+ch+....sssshalhsLAluDLlhslsls.hshhhhhh.........pWshGp...hhCclhshhhhhshhuSlhhLsslolDRYlAIscPhphtthps...tpuhhhhhhlWlhuhllulP.hhhhttpt.pps.............hhChhphsp.............hhlhhtlhsFhl.PlhlhhhsYhhIhppltpptt.................................................................................................................................................ppcp+ss+hlhsllslFhlCWhPatlhhhltshpphs............hthhh.lshhluhsssslNPllY	...................................................................................................................................................................................................................................................................................................................Nh.h.s..l....h....h.......h...h...t........p.....p......p..h+...................ss......h...p...h....h...l......h...s.....L....A.h.....u..D.....h.......h......h...............s...h............h.....h..................h........h.....h........h........hh................................a.........h......u.............h.h...C......p.....h.........h.......h..............h.......h............h.......h........h........................h...........h.......s......o.....l..........h......................l..s.h..l....u......h......-................R.............a...............h.........s................l......s......p.......s................h........p..........h................h.........t.............h.....h..............p...........................p..............t...............s.......h......h.......h......h.......h......h........h........W..............h......h.........u......h.........h..........h......s......h......s.........h........h.........h.....................h...........t...............................................C.h........h.................................................hh.h..h..h...h...h.....h.....h.....a.....h.....l.......P.....h......h....l.......h......h......h......s.....Y...h...h...l...h...h...t....l...t.....p...t..t...t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..t...c....t....c......h...h....p....h........h....h............h....h....l...............h....h.......a....h...l....s........a....h...P.....h....h.....h......h........h.....h...........h.h..........................................................h..h......h.........h....h....h...h........s...s...hhsPhlY............................................................................................................................................................................................................................................................................................................................................................................................	0	5181	6677	11247
+1052	PF00002	7tm_2		7 transmembrane receptor (Secretin family)	Sonnhammer ELL	anon	Prosite	Family	This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognised. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 (Swiss:P48960); calcium-independent receptors for latrotoxin (such as Swiss:O94910), and brain-specific angiogenesis inhibitors (such as Swiss:O14514) amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins (e.g. Swiss:P83119). Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.78	0.70	-5.29	31	4718	2012-10-03 04:04:29	2003-04-07 12:59:11	19	348	246	3	2544	4248	5	225.10	22	28.73	CHANGED	hhslpllhhlGaulS.LsuLhlAlhlhshF.RpL+CsR.NhIHhNLhhoalLpshshhlt.tthlhspht....p...................................h....C+lssshhpYhhhsNFhWhLlEGlYLasLlshs.....ahs-.+thhhhahllGWGhPslhlssWshs+...............hhats............spC.Whsp..ptshh....WlhpGPlhhslllNhllFlpllplLhpKlp......ssphucpcptph.................................hs+ooLlLlPLLGlpall..hhhhsss......phlhhahphhlsSF....QGFhV	.......................................................................h..hthl.hlG.h.sl...S...lh...s....Lh...h..sl.h...h......h......h......h..............h.......+................p...............l.................p............s.....p.....c......s......h.....l....p........h....s.L....h.....h.......u.......h....h..l.......t....t..h....h..h......l...lt........h....h..tt......................................................................................................................C.p...hhs.hh.h.aa.h.h.....lu.s..ah.....W..h...h..l..Eu...l..h.L...a.....h.....h...l.shs...................h..s.p....p.....t.h.h..h.....h.....a....h....h..l.....G.........W....G.............h..Ph.l..lls..l...h.sshp.......................tha..t..s.......................................p..t.....C....W..hp........pt...h..hh.............a....h...h...h..u.P...h...h....h..h.l.h...........l.N....h.l..h...h.l.h..h.....l.h..h..l....h...p.php..........tt.p.h.t...p.t.p.p.hh..............................................................................hhh.s.s..hh....L..h.....L...h..G.....l.....pahh..........h.h.....h....h.......tp..........t...hh....hh.hh.hh...hsuh....Q..Ghhl..............................................................................................................................	0	852	1057	1672
+1054	PF02949	7tm_6		7tm Odorant receptor	Bateman A	anon	Pfam-B_436 (release 6.4)	Family	This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-11.67	0.70	-5.57	36	3836	2012-10-01 21:54:26	2003-04-07 12:59:11	15	33	114	0	2186	4221	0	248.70	14	75.32	CHANGED	shsphhpslphhssshsshhKhhhhhhpppchtclh......ptLppl.tcsh.ppp-phhhtphhp...ptp....hlhhhhhhshshhshhsh.....lshlhttpt..............sh.hhh.......h.hsap.....sph.aah.thhhphhshshsshttlssDshhhhhhhhlshphclLpt+lcpltts................................................................................ptsppp.....ppLtpslppHppll..................chsptlpshhshshhspFhssuhllshshhplhhhss...shphlhh...lhahhshhhQlFhhCahuspltppupplspAla.pss.Whs......tshch++hllhhht+sQ..+shplpAss.hhslsLssahslhphua	.....................................................................................................................h..........................p.h....hh................h......h................t...h.............................................................................hh................hhhh......h.h...h..h..h...h...h....h.h.......h..h.h.h...................h....h..h...............................h.....h..h................................h...h...............t........hhh....hhhh.p.h.h...h.h.....h...hshh.......h...........sh.s...s.h........hh.h...h...h.....h....h.t...h..p...hph..l..t....p.l.pp.h.t..........................................................................................t..t..................ttl...h.t....h...lphHttlh................................................................ph.hp..h....p....t..h.h.t....h....h..hp.h.h...h....h..h.h.l...s..hh...h.............h...h..h...h........................h...h....h...................h...h..h...h...h...h...h....h...h...p.h..h....h.hsh..h...up....l.................t............st....pl.hts..h........a...p........W....h.t..............hs......p.....pp.......lh.hh.h.psp....p..sh...hpsh..hh....h..s..h..hhth.........................................................	0	582	712	1980
+1055	PF00207	A2M		Alpha-2-macroglobulin family	Finn RD, Sammut SJ	anon	Prosite	Family	This family includes the C-terminal region of the alpha-2-macroglobulin family.	20.40	20.40	20.40	20.40	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.07	0.72	-4.41	131	2819	2012-10-03 02:52:13	2003-04-07 12:59:11	17	148	1230	58	881	2534	98	88.80	26	5.98	CHANGED	oWlWpsh.ls........t.s...GptslshplPDoIT.oWphpAhulosst.........................GlGlups...plpsh+sFFlslpLPYSlhRGEplplpssla.NY.hsps..lp.lpVpl	............................................hha...hhs.............tp....Gpspl.shh........lPDo...lT...pWc.lh.A.....h.u.h.s.s.s.......................................................s.hGhscs........plpshp...shhlphshPh..ltpG-p.hplthslh.Nh...h.sp.s...p.hpl............................................	0	218	372	622
+1056	PF01835	A2M_N		MG2 domain	Bateman A	anon	Pubmed:16177781	Domain	This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin [1].	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.41	0.72	-3.75	175	2926	2012-10-03 16:25:20	2003-04-07 12:59:11	14	140	1451	60	921	2616	150	95.90	22	6.25	CHANGED	psalhTDRslY+PGcsVph+sl..shs.................t............slp...lplhcP.sGppl.pphhh............Ghhphs.aslspss.hGpaplpsph.........................tstthsstpFpV	..............p.halhTD+slY+PG-s.V.phpsl..hhchc.....................................hpsh.ss....pslp...lp.l.....h.cP...sGp.h.l.pph.s....................t..pp...Ghh..phs..at..L..sps..s....s..tG....taplpsph...............................t.sphhphpFpV............................................	0	235	407	669
+1057	PF01356	A_amylase_inhib		Alpha amylase inhibitor	Bateman A	anon	SCOP	Domain	\N	25.00	25.00	25.00	58.00	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.41	0.72	-4.18	6	15	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	13	7	1	19	0	65.90	51	70.74	CHANGED	upPAPACVchapSWRYTpVsNsCupsVSVTVsYpDGspuPCtslsPGslsTFu.GYGTpuNaVpulshC	.t.pPAPACVchapSWRYTsVsNsCussVoVTVsYpDGppuPCRslsPGshsTFu.GYGTpGNashulthC	0	0	1	1
+1058	PF02137	A_deamin		Adenosine-deaminase (editase) domain	Mian N, Bateman A, Iyer LM, Zhang D, Aravind L	anon	IPR002466	Family	Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc [2].	19.80	19.80	21.20	19.90	18.90	18.60	hmmbuild  -o /dev/null --hand HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.43	0.70	-5.12	59	781	2012-10-02 00:10:39	2003-04-07 12:59:11	13	25	275	2	446	770	16	308.00	27	55.17	CHANGED	oluTGsKslss..pphuppGph....lpDsHAEllARRuhhRaLhpplthhhpt......t.tpsl....a..............h.p..tssth........acL+sslphaLYlSpsP.CGDAsl...tp.............................................................................................................................................sstthlsscsss....tsh.shpGll.htsspu...-phhoh..SCSDKls+...........WsllGlQGuLLuphl..cPlYlsolllu..t.........hpts......phpRAht..pRh.....................tth.tsaphpp.Phht.......t.......................................................................tspsppptpsss.............................hSlsWsh...............sshplplsss....ppGp.........sshtstSclsKtshaptatpl......ht............ppphts............sYt-hKpts...ppYppsKpplhpt......................tshssW.lpKs.-	...........................................................uluTGs+Clst.......phh.s....pG......h..............lpDsHAEllARRuh...h.R.aL....hpplthhh...st................ppol..a...........................................................t.....t..t..s..............................................................apL+.pslphahYh.S..psP.C...GDAphhs.hp...............................................................................................................................................................................................................................................ssttslss.p.s.s...s..............sh..ph.Gll.............p.u.....-.....p..hhoh..SC..SDKls+...........WsV...lGl...QG...uLL..ophl...pP.......lYlpol..llG........................hptt.......................................thpRA..h..h....pRh...........................................t.htth...athpp...shht...............................................................................................................tsptpt.hpsss.............................hS.ls.Wsh...................................ss.pl.pl..hss..ppGp............................tshtt.SplsKtthhthahp.l..................ht.h.....................ttth.t................................sYt...phKths..............ttYpt.s..pp.hhp........................shssW.htps..........................................................................................................................................	1	123	188	317
+1059	PF00324	AA_permease	aa_permeases; 	Amino acid permease	Finn RD, Bateman A	anon	Prosite	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	478	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.47	0.70	-6.16	26	17705	2012-10-03 01:44:59	2003-04-07 12:59:11	16	47	2920	0	4452	25995	1856	417.10	27	85.04	CHANGED	clhhhuluuslG..sGLalusuhsltpuGssus..llua.llsuhhhhhhhhuluEhushhP.....puGuahsaus+hlus.phGhssGhh......ahh.hhhslsh-lsssshhlpaW...hscls.hhsh..................sslhhsllhhlshhul+hauchEah..hshlKllsllsFlIlu...hhhhtsstssps.............t.hhtsus.....hsss.........htshhushshshFuas.GhEhluhsAuEscsPpKslP+uhppslhplslhYl....................huhhhlshhlshsssshhst...s...........................ushshhhphtslsshssllshslLsusLSuusuulasuoRhlhuLuccshhP.....phhpths+pusPhtulhlohhhuhlsh........lhsthsss..hlhsahlshsulsshhsahhhhhshh..taRpshthpstthstlshchhhhshhshhslhhlhhlhlhhshhhh......hs.......hssts.htsalshhlhllhhhshthhh+phhsphhh	................................................................................................................................HlphIA..lG.G...s..I.......G...sG.L....F....l......G..u..u...t.........s.........l...p..............A......G................P...us............llu.Y..hl.s...G...h.........h............h......a......h...l..M...p.u.L..G............E..h..s......h.....t.P............ssG........S........F......s................s....a.......A................p......c......h..............l...........u......s......h..............h....G..........a....h..s.G.Ws.................................Y.a.h....t....a............h......l.....s.........s....h.........s........-....l......s....A......s.......u.....h.......h...h.......p......a.....W.............h.....P....s....l....P......t.W.l..h..................................................................s.h.h.h..l...h...l....l....h.....s....l....N.........l....h....u....V....+...h....a...G....E....h........E.....F..W........F...u...h....l....K...V....l....s....I..l....s.....h...I.lhG............h...h..h.h...h.s.s..tssst......................................................ht.h..h.p..p..Gu....................................h....s.....s..G.......................................................................h......h......u....h......h....h....s....h.....h...h...s....h..F........u....a.........t......G.....h....E...l..l............u.........l....s....A..........u.E....s..c...............s.........P....p......+................s...........lP...+..A...........l...p...p...l...h...h...R....I....h...l.....F..Y.l.........................................h..u...l....h...l...........l.......h...h...l..h........P....a....s....p...h....s....h....t..s................................................................................................S..P..F..l...h...h....h....p....t.......h.......G.............l...........s.....h....s.......u......s......l........h.....N....h....V.....l.......L....o.....u....s....l.........S..........u....s....N.....S.........u....l....a.....u.......s....u....R...h...L....a.u.L..u....p...p....G.........A..P...............................ph..h...s.....+..h.....s.....+.................p.........u....l..........P.....h.....h.....u.....l....l....h.....o........s....h..h....s..h...l.u.h..........................................................................l...h..s.h.h.sst...........ps..a..h...h.....l....h....s.......h...u....s..........h.....s.......h...l....h.....s......W...........h.......h..........I...h...l...u..p.h..............p.a...............R............+.............t...................................................p......s.............t..................h.........t.................p....h..................a........+.........h...............h.......h........s..........h.......s..........s..........h.................h.......s.......l.......h.........h......h...h.....h...l........l...l......h...h......h...h..t.............................................ht...........................................................................h............h....h...........h..h...h..h...h..h.......h....................hh......................................................................................................................................................	0	1009	2148	3513
+1060	PF03306	AAL_decarboxy		Alpha-acetolactate decarboxylase	Mifsud W, Sammut SJ	anon	Pfam-B_3661 (release 6.5)	Family	\N	25.00	25.00	25.70	25.60	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.12	0.70	-5.30	71	1480	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1246	4	233	763	52	214.90	42	90.92	CHANGED	laQhSTluALhsGlY-Gsholu-LLcHGDaGlGTFspLDGEhIhlDGpsYQhcuDG...s.sp.ls.ssp.psPFAslThFpsc.hphphtpshshpplpphlpphhs.upNlFhAl+lcGpFppl+sRoVsp.QpcPYsshs-sscp.QshaphpslpGTllGFaoPpahp.GlsVsGaHlHFlo-D+phGGHlLDapl.psuplplshhsphplcLP.pstsF....hpuclshps	..........................LaQauTLuuLhuGLhcGTholsELL.cHGD.h.GlGThsulDGE.lIhL.DGcsY..p..sp..u..cG...p.hh.c.l....p....s.-............p...hsPaAslT.Fps-...hpa...p..................p..p.p.h.o.pcplpt....pIcph....h.....uc....NL....FtAlKI.pGpFp+..h+lRhhPp...QptP.Ys.phh-succ..QPEaptps.lpGolVGF.aTP-hac.Gl..us..AG..aHlHFlsD....D+saGGHVhDFtl...ccshl-..ltshsphc.+hPhpspsFhpAclshcs................................	0	52	122	182
+1061	PF04611	AalphaY_MDB		Mating type protein A alpha Y mating type dependent binding region 	Kerrison ND	anon	DOMO:DM04516;	Family	This region is important for the mating type dependent binding of Y protein to the A alpha Z protein of another mating type in Schizophyllum commune [1].	25.00	25.00	57.40	234.00	20.90	19.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.31	5	6	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	2	0	1	6	0	146.80	51	15.97	CHANGED	MsDpLusL+uISAsAKuMsulAtSRGApssPsPhssTsV+..FDPLPoPsLDuLRoRLp-A+LPPKulKSALuAYEcACuRWRp-L-EuFcpTA+SVSP+NLHLLssLRaRLYTcQVEKWtsQVLQVPE+W+AEMEKQRAHIsATMGPu	Ms-hLusLpuISAsAKsMhulAtSRGApss.pPhssTss+..FDsLPsPsLDhlRoRLp-A+LPPKulKuALuAYEpACuRW+p-L-EuFcpTA+SlSP+NhHLLspLRhRLYscQVpKWhhQVLQVPE+W+AEMEKQRAHIsATMGP.s	0	1	1	1
+1062	PF03417	AAT	Peptidase_C45; 	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	Bateman A	anon	MEROPS	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.28	0.70	-4.90	18	964	2012-10-03 21:14:07	2003-04-07 12:59:11	11	16	794	14	316	1078	61	218.40	21	58.87	CHANGED	hpscss.....hlu+NhD..htPthhssphhlhts..............sGasslsh...supl..Gps.GhNcpGLshsh........Nhhph+ph.ssGhsphhltRhlL-.ssols-AlchLp-h....PctuuhsalhlDpstphshlElsssstsh......sl+css..thhhpTNHh..........................ppshppts......pphhcsShpRhp+hpphhspttss...ppshchhsDtpst.hs.....pphsshtsTla...oulaphtstphphslupsst	..........................................................................hp....t.....hhs+N..aD........hps..t...h...h..s...t...t.h...hh.hh..................................suh.s..t..l..s.................su.tl....Gp...h...t.GhNcpGLsh..sh...................N.h...h..p.....t....c..p...s..........s..s.....G.......h......s..t..h...h....l...h..Rh.....lL-.spslsEA.lp....lL...cch..............sttu..u.......h.sh.hl..h...D...p.s.....t...s...t.sh..l.E...hssp.sh..........................slt.ss.......t.hhp...T.NH.a......................................................t....h....h...p...p....s......................p.h...hp..p...S..h...p..Rh.......t.+h...tp...hhs.pp.sh.............ttsh.......p.......h.h.p.s.t...t.....hs............................h...p.....p.....h.............s....T..lt.............oshap.p..phph.hh.st...h................................................................................................................................................	0	115	199	275
+1063	PF02496	ABA_WDS		ABA/WDS induced protein	Mian N, Bateman A	anon	Pfam-B_2496 (release 5.4)	Family	This is a family of plant proteins induced by water deficit stress (WDS) [1], or abscisic acid (ABA) stress and ripening [2]. 	25.00	25.00	28.10	28.10	23.00	19.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.93	0.72	-3.81	17	393	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	64	0	39	374	0	70.70	70	52.27	CHANGED	.cY+KEEKHHKHhE+lGcLGAsAAGAaALaEKHcAKKDPEHAH+HKIEEElAAAAAlGAGGaAFHEHHEKKEAKcEpcEu	..........-YcKE.KHHKHLEclGcLGAVAAGAaALHEKHcAKK.DPEHAH+HKIEEEIAAsAAVGuGGaAFHEHHpKK-A+cctct...............	0	1	18	30
+1064	PF00950	ABC-3		ABC 3 transport family	Bateman A	anon	Pfam-B_1591 (release 2.1)	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.50	0.70	-5.09	16	7614	2012-10-02 17:14:55	2003-04-07 12:59:11	12	12	3931	0	1534	7023	2698	251.50	28	90.95	CHANGED	pacahppAllsulllulssulLGsallL++hSLhGDulSHusLsGVuluahLuls.....hhhGAhhhulluAlshsalcppo+l+pDsslGIlhushhulGllllolhpt....spssLtpaLFGslLulsppDlh.htllssllLlllllha+chlhhoFD.shApshGlslphhphhLhhLlulslVsulpsVGsILVhAhLlsPuusAhhhs+shcphhllAsllGhloshsGlhlSahhs.suoGssIVlltshlFlluhhht	.................................................................................................hpFh.pAh.ls.ulhl..u..l.s.s.u.h.l.G.s..a..l..l..lRp...h...ohh....G.D....ul...S.H..u....sL........s....G.....l....A...l...u..h...h......l...u.hs..........................hl..u....u.....h...l.....h...u...l.....l...s...A....l....h.......l....t....h......l.......p.......p.....p....s.......p....h...p.....p....D.......s.....s.....l......G.....l....l...h.....s.....s...h...h.....u...l......G.....l.....l...l.....l.o.h.hs...................sss.s.L.......s...h...L...F...G..........s..l...................L............u............l............s.........................p.............D............l............h...........h............l...........h...l....lu...s.............l......l.........l...h.....l..l.h.lh...a...+...p....Lh.hhoF...D.ph...Ap..s.t.G.l.s....s....p..hl.ch.l...hhhllulslssuhpsVG...slLlsuLL...l...hP....u.A....s.A.h.h.l....s..c..s...h..p.....p....hhh.l..us.hl.u....h....l....u.s....h....h......G........l....h........l...S.............a....h........h.............s......h...........s.....sG.....ss.I.Vl.h..ts...h.lFllshh.t.................................................................	0	472	958	1282
+1065	PF01061	ABC2_membrane		ABC-2 type transporter	Finn RD, Bateman A	anon	Pfam-B_865 (release 3.0) & Pfam-B_31 (release 15.0)	Family	\N	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.52	0.70	-5.17	298	15925	2012-10-03 10:13:34	2003-04-07 12:59:11	19	140	4416	0	7264	20686	4522	204.80	15	46.78	CHANGED	pphtslhtRphh..phh+ss.ht.h........hphhps.llhsllhGhlaht.............t....thh.th.................huhlhhslhhhsh.shssh.shhhpppshh.h+phstshhphhshhluph...lsp.lshshlhshlhhh.lsah....h...h....uhpht..........h.....hhhhhhhhlhhhhhsu.huhhluuhs.shp.sshls.shlhhshhhhuGhhhshspl....s.....ahp..a.hhhlsPhsashpu.hhhs.h	..............................................................................................................................h..hhhlhh+phh....thh+.s......h...h..h...................ht.hlt..s...h..l....h....h.l..l...h.....u.h..l..a.h.t.............h..........s..t.thh...h............................................................................................................................s.uh.lhh.h.h..h..h...h....s....h........s....h...h........s.......h........................h........h..h.....h.....t...p....p.......shh....h.......+............h...s....t...........s...h.........s....h.....h.s....h.....h.....h..u.ph..................l.st....h...s.....h.........s...........l..l...h...s...hl.h...h...h...l...s..hh...........................h.....h...........................u.h.pht.............................th...........hhh.hh..h.h....h...l...h.s.h....h.......hss....hu.......h.h...l....u.s..........h...s........s..h.....p....s...s..s..h........l..s....s....h.l....h..h....h..........h...h..........h...h.....u...G.....h..h.h...s......h...s.........th......P....................h...h.p.........h..l.h.....h.h.sP.htahhpu.ht.s................................................................	0	2247	4566	6342
+1066	PF00664	ABC_membrane		ABC transporter transmembrane region	Bateman A	anon	Pfam-B_2 (release 2.1)	Family	This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (Pfam:PF00005) have two such regions.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.40	0.70	-4.99	70	51056	2012-10-02 13:23:42	2003-04-07 12:59:11	18	190	5230	28	16541	42384	7093	265.40	13	43.23	CHANGED	lhhshlhthlsshhthh...hshhhuhhhsh.............hsssstp....................psshhhhhhh......................hlhhhhh..hshhhhsh.has..htthst+lptplhpp.lhc.phhp..h..s......pppssGplssRlosDssplpssl.stplhhhh.tslhhhlsshllh...hhh..uhpLsLlhl.hhslhhhhshhh.sphhpphpppppps.........hsp.hss....hhpEslsulcTVpuastppthhpcappthpp.hpptshptshhsshhhs.htphlhhh.h.shshhaGs..hl...shtsths..ssplh.sshthhthhttsl	.................................................................................................................................h....hhhhh.h....s.h.hthh.........s.h...h....h..t.h..h.ls.......................h.tt.t..................................................................t..h.h..h..h..hhh....................................................................h.h..h..h...h....h..h.......t.s...h.......h...h.....h...h...h...h..hh...................h.t.t....h....u....h....p.....h....t..........t......p....l....+..............p.p.....l....h...p....+..l..hp.........hs.h....s.hh..........................pp.p.s....s......G...........p....l....h.....s..........+.......h....s.................s..............D..h....p....p....l.....p.....p................h....h...s.........p..h....l................t....h.................h......t....s..h....h..............h..h..l.....s.......s...l..h..h.h................h.h.h........s..h..t...l....s....l...............l..h...l...h...h...h..s....l....h...h...........h...h....h..........h.........h....h.....t......p..........t...........h.......p...p...h...t.......p.......p.h....p...p.t.....................................................hup...hs..s...............h.h.p...E..s....l....p....G...h..p.....s......l.......+...s...........a.....s......t.........p........p........p...........h....p.......p....h.....p....p..........t................p.......p....h.......h....p...t...........t......h............p.......h........t........t.....h....t.............s.....h..h.....t..s.....h....h..t.........h...l......h........h.......s.....h....s...h.....h.h..h..h....uu..........hh..............h.h.t.s......p.....h...s........hG..t..h...h....s.h..h...h.h..h....h......................................................................................................................	1	5333	9845	13729
+1067	PF00005	ABC_tran		ABC transporter	Sonnhammer ELL, Bateman A	anon	Prosite	Domain	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes.  ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664.  These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null --hand HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-3.87	55	363409	2012-10-05 12:31:08	2003-04-07 12:59:11	22	730	6447	300	93265	270413	81790	147.80	27	41.67	CHANGED	LpslshslptGchlullGtsGuGKSTLLphlsGhhpP.....spGpl.....................hhp.spsht...........hpthcppluhl.Qp..splhspho.lt-slh.s..........................................hhthtppttpsc........hpphlpplshht..........................hhcphl..............tpLSGGp+p..RlslA+slhppsplLlLDEPTs	.....................................................................................................................................................................................................................................................................................................................................................................................................cslsh.p.l...p...p..G..c.h....l...u....l.....l...G....s..s............G.......u....G..K........S.....T....L.....l.........c.....h.....l....s......G....h...h....p..s........................s.s.....G.....p...l....................................................................................................................................................................................h..l...s....G....p....s...ltp....................................................h.t....t..h.....p.....p.....p.....l.......u....h.....l......h...Qp.........hs.L..h...s....p...h...s....lt-slthsh....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................thtttptppc....................h.p...p..h..l.....p...t......l....s..l.t.t....................................................................h....p....p...h......h........................ppL..S....G...G........p.......+......Q.............R........l..........s..l....A.....R.......A........L...........h............p............p...........P..........c..........l......l.......l.l.....D..EPT...............................................................................................................................................................................................................................................................................................................................	0	28903	57358	77150
+1068	PF00561	Abhydrolase_1	abhydrolase; 	alpha/beta hydrolase fold	Bateman A	anon	MRC-LMB Genome group	Domain	This catalytic domain is found in a very wide range of enzymes.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.07	0.70	-4.80	48	9019	2012-10-03 11:45:05	2003-04-07 12:59:11	15	58	3408	175	3041	47284	15466	242.40	13	59.97	CHANGED	acllshDhhGhGtSs..................................................hsthshpshsc.lptlhp.phshpp......hhllGaShGGhluhthstphsp....plpsll.hhss......................................................................................................................hhhtpshhtt............hh.thhhshhhshhhsshpthhstth................htshpp..hsphhptht...hpshhp....shthsshht.................htthhttshhthhpp......hpsPslllhuppDp...hhs.pst.t.htphhsp.......s..phhhhss..uHhs........hhppssph..sphlhs	..........................................................................................................................................................................................lhhh.s...t.G..s.sh..us....................................................................................................................tht..h....t....p....h....s.......h......p....c.......h......s.....t.........s........h........c......t.......l........h...........p......t........h......G.......h....cp................hsh....l.G.t.S.h..G.G....h.....h.....s....h....t....h....h.....s......p...h.Pp.................pl....p....s...h..l...h.h.us.h..............................................................................................................................................................................................................................h...h...t..t..t.....ht...............................h...t..h...........h...t...........h......h....t................h.....h......t...............t................h....s.............h......................................................................................................h............t..................................t..................ht...................hh...................................h..h....h.......................................................h................t...s.......................h.tt.....................................ht...h....h....h....h..h.....t..h.....t.....p..D.................h.h....s................t..........................t......................t......h.........t...............................h........h.........t.......tH................................tt...........................................................................................................................................................................................................................................................................................................................................	0	897	1658	2474
+1069	PF03806	ABG_transport		AbgT putative transporter family	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	19.60	19.60	19.60	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.73	0.70	-6.50	9	1493	2012-10-02 15:12:49	2003-04-07 12:59:11	8	3	1103	0	203	1520	191	425.00	40	96.44	CHANGED	RFLshlE+lGNtLPcPlhLFhhhhllLhVsSuIhSshuhSsssPhs.Gst...........hlplhsLLos-GLthlhsshlcNFouFsPLGlVLVsMLGlGlAE+SGLluALh+shlppsP++lloshllhlGllSpsAuDAuYVVL.PLuAhlFhulGRHPLAGLAAAaAGVSGGFoANllluthDsLLuGhTppAAphIDPsa..ssNPhsNWYFhsASshVls.luhaVT-KlVEPRLGsapss.tppptspht...lTstE+KGL+aAGluhllhlALh.shsllPtpuhLRs.cssslt.soPFhpulVshIhllFllPGlVYGhlstol+sp+DVsshMu-uMuoMGsYIVlsFFAAQFVAhFsWSphG.llAVtGAchLcshsLsG.sLlluhIlluuhlNLhIGSASAKWulhAPIFVPMhMLlGauPEhoQAAYRlGDSlTNlITPhMsYFsLlLshsp+Yc.chGlGTLlShMLPYSlsFhlsWhlhhhlWhh.LGlPlGPGushtY	.....................................................................................................................................................................................................................................................................................hLshlEhhGN.tlPcPhhLFhhhhlhlhlhohlh..uh..hs.h.s..sh.pP.............t..t......................................l...hl...h...s..L..L..ss..-....G....l....p..h....hlss.hlpNFs.sFs..P.LG.hl.......LshhlG..l.G...lA..EcoGhlssh...hhthl.t...t..s....s....t...p....h..lo....hl...l...h..h.ulh....u.p....h..A...u.D..u.u.....h....V.....l.....l...PluAhlFhuhGRHPlAGlhsAaAuluuGas...ANl.l.lss.hDsLLsGhop......t......A...A.......p...h..l...s..s...s...h......pl..s..s...h.sNaaFhhsSshllshlshhl.T...-Kl....l...c....P+..L............u.p........h.....p......s..........s...................................t......p........p.........h................p.................................lT.t.Ep+uL+h.A.s.l.sh.ll.h.l......sl.l.hhh.h.....lP..................p...s.uh.LR..s...st..s...........t.............h..l............h...suPhh.p.uIl.slIhlhFhlsGlsYGhsstph+....sp....p....Dlh.p...................hMsc....s....h....p.s..M..u.s.a.I.V....hsF..hsAQFlA.h.F......s.a.S..N..h.G..t..hhA.l.....tG..Ac..hL...c.s.......s..hsG......s..hhlu......h.l.ll.s.u.h.lNhhluSuSApWulhAPIFVPMhMhl...G..hpPthsQhhaRlGDSsoN.l....oP....h..sah..sLll.s.a....h..p.+Y.....p..............c.............p....ht..lG.T.lh..Sh.hlP.Yol.hh.hl.sWhlhl.l..hWah..lGlPlGPGs....h.............................................................................................	1	57	123	167
+1070	PF02230	Abhydrolase_2	abhydrolase_2; 	Phospholipase/Carboxylesterase	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_1382 (release 5.2)	Domain	This family consists of both phospholipases [1] and carboxylesterases with broad substrate specificity, and is structurally related to  alpha/beta hydrolases Pfam:PF00561 [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.31	0.70	-4.90	12	2930	2012-10-03 11:45:05	2003-04-07 12:59:11	11	32	1915	13	1262	4011	3116	197.40	21	84.53	CHANGED	hs..tlhsstp.tpsslIaLHGLGDsu.....cuhu.sht.thsh.pspaIhPpusp.hPlshstGht..uWF-lhshs.st..p.spssltputpplppLl-t-hcpG............lssscIllGGFSQGuhluLassLop.p...luGlluhSuhhshttph.pt.stss...phPlhpsHGppD.llPhthGttstchLpshht..psphpsapthuHu.sspphpsltpalpphl	....................................................................................................t............t....t..p..t.h..l.l.h.lHG....h....Gsss.................ph.h......s.........h..................p...........................h.......................h...............t............h......p.h....l..h..s..p..u.....s.......h........................s..........s...............s............t.....G.......h....................................t....W..........a..............s......l.........s.......h........s...........ps........................c.....t.........t............tl...p..t.......s.....h.t...t.l..t.p.....h..l..c.p....t....h...p.p.s..........................l.s.s.p..c.l....h....l.sGFS.Q..................Gu.......s.h.u.............lt..s...s...........h...........p...........t............s.........t..........................h....u..........u...........l.....l...u....h....S...........u..............h..................h...................s.................................................p...............h................t.........t......................................p..........s.......................t.............t......h.........s.....l......h.h.h.HG.p..t.Ds.l.l...s.h.t..h.u.t...t.s.t..p....h.Lpphuh.............plph...c...h..........h...sH......t....l..s.......p..php..hhpalt...h................................................................................................	0	362	705	1015
+1071	PF02517	Abi		CAAX protease self-immunity	Bateman A, Bashton M	anon	Pfam-B_1073 (release 5.4)	Family	Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases).  The family contains the Swiss:Q03530 CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding [1]. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin.  Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.29	0.72	-3.85	1333	12845	2012-10-01 21:07:14	2003-04-07 12:59:11	11	37	3734	0	2636	9172	1289	110.90	21	43.17	CHANGED	hhhh.......hhh......hlh.......................................................hslh...ss.l..........sEEllFRG....h...l........................................................................................................................hs...t............................................................................ltph............hh..........................hhulllou.llFul.hH..............h...........................hh.....h..................................................................................................lhh..hhh....G...l.....hh......u.....h....lh...........h........po..t..s...............lh.sslhhHhhhNhh	.................................................................................................................................................................................................................................................................................................................................................hh...hhhhlh......................hslh...ssl........sEEl...laRG....h....l.........................................................................................................................................................................................................................................................................h..s..t.............................................................................ltpt.........ht..........................hhulllou..llFu.l.hH...hst..............................h.h.....h..................................................................................................lhh...hh..h....G...l.....lh......u........h....la...........................h......po...p..s...............lh....ss.l.hhHhhhNh.........................................................	0	995	1783	2287
+1072	PF03992	ABM		Antibiotic biosynthesis monooxygenase	Yeats C	anon	Yeats C	Domain	This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is  suggestive that the other proteins function as  multimers. There is also a conserved histidine which is likely to be an active site residue.	21.90	20.90	21.90	20.90	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.39	0.72	-3.94	114	8140	2012-10-02 00:20:33	2003-04-07 12:59:11	11	50	3128	85	2223	5804	1847	77.50	17	63.08	CHANGED	hhhlhsphp.lpsspt.ppahph.hpphsp.......hhtspsGhlphplh.........p....s..hpsssp.ahlhphWcs...psu.hpsatpo.........spapphtpt	.................................................hhhhsphp..lp.s.spt...pphhpt..h..p...p..h..ht........th..ppps...G.hlshplh.....................p...............s...hps.s..s.p..h..h...h...hp..t.....Wc.s.......ppu...h.p.s.a.t.p.o..........spapth...t..........................................	0	615	1296	1802
+1073	PF00887	ACBP		Acyl CoA binding protein	Bateman A	anon	Pfam-B_864 (release 3.0)	Domain	\N	21.90	21.90	22.20	22.30	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.06	0.72	-4.32	101	1677	2009-01-15 18:05:59	2003-04-07 12:59:11	14	62	583	29	963	1596	101	85.20	32	33.64	CHANGED	hpppF-pAsphl+pLsp........pPos-phLcLYuLaKQAT.G.css..ss+P..Ghh..............Dhhu+sKW-AWppl..cGh........S+--AhppYlchlpp....lhp......phu	.................................ptpFptAs.ph.l.c.p..Lsp...................pPss.-phLcl..Y..uL..YKQ..ATh.G.sss.............ss+P.....Ghh.............................D.hh.u+s..KW.....-.....A.Wppl....puh.......................o.p--AhppYlphlpplht...t........................................	0	305	482	749
+1074	PF03255	ACCA		Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit	Mifsud W	anon	Pfam-B_1935 (release 6.5)	Family	Acetyl co-enzyme A carboxylase carboxyltransferase is composed of an alpha and beta subunit.	21.30	21.30	21.40	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.66	0.71	-4.64	15	3540	2012-10-02 13:07:06	2003-04-07 12:59:11	9	7	3419	3	719	2292	2130	133.30	51	41.80	CHANGED	hhL-FEKPlhELEpKIspLcclup....cschslssclppLcc+hpcLp+cIausLoPaQRlQlARHPcRPoTLDYIptlh--ahELHGDRshuDD.AlVGGlG+lcG+sVslIGHQKGRDTK-pltRNFGMssPcGYRKALRLMchA-	........................................................p..L-FEpPlh-lct+IppL.p...h.tp............p.........t....l....s........h..s...p.ElptLcp.+.........p..htc.....c...l........a......s..sL..ssWphsQl....ARHPpRPhTLDYlptl..F..s..-..Fh..E.....LHGDRs.au....DD.t......AIVGGl..A........+.l.s........G........p........P........VhVIGpQ.K.G............+cT..K...........-plpR........NFGMPp...PEGYRKALRLMchAE..............................	1	237	478	613
+1075	PF00871	Acetate_kinase		Acetokinase family	Bateman A	anon	Pfam-B_1595 (release 2.1)	Family	This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.	22.00	22.00	22.00	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.10	0.70	-5.93	11	6003	2012-10-02 23:34:14	2003-04-07 12:59:11	12	14	3886	38	1171	4042	326	366.90	38	95.86	CHANGED	KlLVlNsGSSSlKFpLh-s........ptpsLhpGLsEpIhlssuhhhhp..stcp.tthsshssHptAlphllssLpp...thhpphs-IsulGHRVVHGGphFosSslls--llcsI+DhhpLAPLHNPApl.GIctstclhPss...pVAVFDTuFHpThPptAYLYulPhshhpcaGlRRYGFHGTSHKYVup+suchLsKPh-pLslIsCHLGNGuSlsAl+sGKSlDTSMGhTPLEGLhMGTRSGsIDPAIlsalt-ppshSss-lsshLNKKSGlLGloGloSDhRsl.-shpc.ucccAphAlchasaRlt+aIGpYhAsLt.splDulVFTuGIGENuuhlR-hhlpsLchlGlclD.EpN.h..phGccslISossS+hplhllPTNEElhIAp	...........................................................................................................h.lLllNsGSSSlKatlh...chs......................s.t...p....h...l...h...p.Gl...s....E.....p....l...s...h...p..s...u...h....h...p...................h..p....................................s..............s.......c.......p..........t....t.............h.....s....h..s......s.....H....p....tA...l....p.h.l..l.p.tLhp..........t..h..h...p..t...h.....s......pl.s..ulGHRlVHGGch.F.s.posll.....s..-.....cV...lp.p.I.c.c..hs..s.L.......A..PLH.NPAslh..........GIcss....p...cl..h......P.s.ls.........pVAV.FDTuFHpTMPctAa.hYulPh.ch.Ycc.....hslRR..Y.GFHGTSHpYVu...pc.u.A...c.h...L.....s..+..............s.......h..................c...clplIssHLGNG.u.SlsAlc.....sG+SlD.TSMGhTPL-GlhM....GTR.SGDlD.P.ull.a....l....h..........p.........p.........t.............s...........h...o........h.c.............c.l..............p....c...lLNKcSGLLGl.o.G.ho.o.Dh...Rs.....l...c...p.............sh...............t...........p.....G.........c............c......c...........ApL.A.h-hasaRltKaIGuYs.A.sh................t.........lD..AllFTuGIGEN.ushlRph..lh.p.t.L.t....h..h......G.l.p...lD.c.tN..t.......hhG..p..p...t..h....I...s....p...t.s..o.p.....l.h.s.hVI.PTsEEhhIA...............................................	0	390	748	994
+1077	PF02550	AcetylCoA_hydro	Acetyl-CoA_hydro; 	Acetyl-CoA hydrolase/transferase N-terminal domain	Mian N, Bateman A	anon	COGs	Domain	This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA.	20.70	20.70	20.70	21.40	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.20	0.71	-4.55	5	2652	2012-10-04 00:26:15	2003-04-07 12:59:11	10	14	1717	21	626	2072	95	179.70	26	42.46	CHANGED	hpcpYp+Klts.PEEAAsLlcsGpHIchGGhhuAuTApulPcYLA+R+sEhspl+ssohIDLtshphloAuPps-hhcpcsuhlaR.ss+pouchsssslNpGllcasshaLSElut..hhspGFss........IDlAlIpTTshDcHG..alNhG..Vo......ssthKuIlEl........AElVllVlssssPalNG.YDthIsl-+V..DYIltDsEhsVshlP	..............................................................................................................................t........hhhs..st.cA.s.th.l..pps...........hlshut....su.sts.ls.....A..ls......p..h..............t...h.t...........h.....h..p......l..h.h.h.t.............s....s....t..t.h..h..t........t.hh.t.h+........sa....s.s.......h.....R.c......t....Is.....p......G..p......s....as.s.h....+LSc.lsp......hh.c.p.s...hhs.....................lDVAllp.........s..ush.sccG.....ah..s.....G..lu............sp.tpp.s.ll.Eh................uth.h...l....l.s.t.s.hP+.p.hu.hs...h..h....h..t..h..s+l...s.h.lh...ss...........................................................	1	243	430	562
+1078	PF00797	Acetyltransf_2	Acetyltransf2; 	N-acetyltransferase	Bateman A	anon	Pfam-B_575 (release 2.1)	Family	Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	21.00	21.00	21.10	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.49	0.70	-4.79	33	2001	2012-10-10 12:56:15	2003-04-07 12:59:11	12	6	1363	31	435	1384	26	229.20	28	85.40	CHANGED	sL-oLpplhttHhpulPFENLslhhG.....csl.sL-lpslacKlVpp+RGGaCaEhNtLhthsLpplGFclshLuupVhhstsst..ssshoHhlLhV.sl-Gc..salsDVGFGus..phhtPlcLtsstsQspshu.hFRl.scpss....tahLpphppppWh.................slYpFslpPpshpDapsts.hahpopPsS.hFspp..hlsuhtss-.GphsLhupphohp....psst..thphphlsssEltcsLpphFslsls...tthl	..............................l-sLptlhhtahtslPF..EN.L.s...lh.h.s...........................p.l..pl...s........psL..hcKl...l........h......p......p..R....G..G.aCaEhNslFthhLpp..lGF.sVphlhu.....pV.........h.....h.........s............s....s.............s.............t..............h........s........s...t.............s.......HhhLlV......s...........l.........c.sp...........palsDVGFGut...h.htPl..L.....t.s......s....h.....s................s....s....t....s.....paRl..h........ppss.................ha.hl..p....t.......t......p......p..p....p....Wp........................................shY..pF..s....h..p.......p.....p.D..a....t.........sp...hast..p..p..P..pS....hF.tpp.........hl..h.......s....p.....h..........h........s.........s.......G.............+..............h.....s...L.s.....s..t..........p......hshh..................tss....hpppp.h.s....tphhphLpp.F.ultl...........................................................................................................................................................................	0	133	234	337
+1079	PF00328	His_Phos_2	acid_phosphat; Acid_phosphat_A;	Histidine phosphatase superfamily (branch 2)	Finn RD, Griffiths-Jones SR, Rigden DJ	anon	Prosite	Family	The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins.  The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase.  The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.16	0.70	-5.12	93	4055	2012-10-02 11:42:54	2003-04-07 12:59:11	17	54	1206	64	1934	3581	41	323.30	15	63.62	CHANGED	pLchVpllhRHGsRsPppshstp..t................................................................................t..h.t.hta...................................................................................pashshGt...........LTst.GttpthphGchhR.p+Ys.................tLhsst........pplhlhoostsRsltSApshhtGhh.sps.............................pshshthlsc...t.sshhhhst.........tsCsthpp......................ppsspthpphppthtpshs........tclsph...................................su.....shshtcshshhshshhppt.................................phpshssl.hsp.....tchhphph..............................................................................................................................hpslpp......hath.............uhspt....htphhGsshhsplhpplppshsppp..........................................................................phphhhhhuHDoslhslhs.sL....Glhpt...........................st.sPauuplhhEha.p.......................ssp...t....hhV+lhhs	................................................................................................................................................................................................lp.l.hl.RHG.Rs.Ph.tt...................................................................................................................................................................................................................................................................................................................................ta.....................................................................................................................................................................th.s..h.thGt.........LT....s....t....Gt......p....hht.hG.phhR.phas...................................................thhp..p.t..h........pplh.hh..u.s......s....pR...s.h.....to............A......ps.....h...h..tGhh.sps.....................................................................................h.sh....t.tht..p...................t..s.th......h.........................tt.ss.th..pp.................................................t.s...t..h..t......t......t....t..t..h...p.ht.....................phpp.........................................................................................tt...............h..t.h...t...h..ht..h...h......h.thhp...................................t.....h..s..p...h...hpt........tp.....tp.hp...............................................................................................................................................................h.t.ph.pt....hat...................................th.s.t.....ht...t.....h...u...t...sh.h...p.....l...hp.tl........tphtp.tt..............................................................................................................................................................................................................phh..hh..hu..........HDss.....l.hs.lhs..sL...........sh..................................................................................................p.ss.h.uuplh..hphap..............p.....................stt.......t......hlph..................................................................................................................................................................................................................................................................	0	702	1050	1602
+1080	PF03767	Acid_phosphat_B	acid_phosphat_B;	HAD superfamily, subfamily IIIB (Acid phosphatase)	Finn RD, Selengut, J	anon	Pfam-B_2784 (release 7.0)	Family	This family proteins includes acid phosphatases and a number of vegetative storage proteins. 	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.47	0.70	-4.99	31	1773	2012-10-03 04:19:28	2003-04-07 12:59:11	9	10	1346	54	323	1170	350	209.70	26	84.65	CHANGED	thpshhshtts.sthtCso....a+.hu...sEspNlhsapshstpshphstpYh..thppaps-.pslsppAhhhAcpht.ps.........sthsshlFDID-TlL.oNhPYhthps.h....Gsctass........pp........as.cWlppGpA.sulst..sl..chhptlhphGhcIhalosRpcs..p+ssThp.....NLpptG.................ap....shc+LlL+s.ps.ps...hpY...KsscRpplhcc..GYpI.............lt......hGDphsDlhG........sspu..................pRsh+LPNPhYhs.	...........................................................s...........................p..................t.tt.s....l......phsu..........hh.ph...p.httt...........................t.hAlshDlD-TlL..ss.ss..a....h..h...........st.c..sa.s.s..........................p.s.......................ah..ch.hp...p..u..t...s...hulPt..sl..phlch.t.p+GspIaalos.Rs...........p..........s.........t..........s.........t..........Thp..........slhp.t.s........................................................ht....sh..s.tl.l.h.t..s...pc....s...........p..s..............................Kts+pphlpcc......hpl................................................................hhh.....hGDs.s.Dhsu..........s+pssscs.......................h+hlhhsNshYts...........................................	0	69	187	257
+1081	PF00330	Aconitase	aconitase; 	Aconitase family (aconitate hydratase)	Finn RD	anon	Prosite	Family	\N	22.30	22.30	22.40	22.40	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.53	0.70	-6.02	11	14106	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	4231	25	4215	11379	9019	338.30	28	64.53	CHANGED	TLhEKlhcuHlst.p..........cpusphLhl..DRhlhp-sTus.Ah.sLtsuGpslppssh..........ohhshDHsIsspsttp......Dlphptshs+cphphLppssKcaulthas.su...GIlHpls.EphhshPGh............TlVssDSHTsstGuhGuLAaGlGsuEsEcVhAsQslp.tpPKshtlclsGKLssGlTuKDlILplhGhlsscGGTGplVEahG-ulssLShpuRhTICNMuhEhGApsGhhs.DEsThcYLcups+A.cutph-cAhshhctLpsDcsA....paDpllcl-hsslpPplshspsPs.shslschssssp.p......t.t.cc..htahshhPt..h.tlcVchuhIGSCTNSphEDlppAAullKpt.....ttlpshshhhVsPGSc.V+sphE+-GLscIFp-sGhphhssGCosClG.s...sDhlps.......tspssoouNRNFEGRpssss+TH..LsSPshssAhAluG	............................................................................................................................................................................................t..h.p-..........h..h......h.......................t..............................................................h...DH..h.......................................................s...........h......h......................................tt..h...t.........................h.........ss.......Glh..H.h.........E..hhhshh............................................................shlssDSHTshhsu.hGhluh............G..........hGs......-.sth.shh.s.tsh.......hs.c.............s.....h..thphp....G.p.h.........thssp...............Dll............Ltl............h......t.......h....h.t......h......t.....t............s............h............G...h...hhE.....a.h..G........u..lt..t.Lsh.tt+hols.NMu.....................Eh.G.A.p.su.h.h..............D.p.............................s....h.......p.................Yl................p.................................p.......................h................t..........................t........................................................h.....................t.............................................................p..................h...........t.....c........ss...........as.t.h..l.p.lchsp...l.t.P.lshspp....Pp.t........hh...ls...th.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................t......ht..l......s.shIsSC.ossp...phhhuAtl...ltt..p.........................t..h..t........h..p..h.lsPuSt......l.....t.t......h........t.....t........t.....G.....h......................thh..p.h...........Gh.t...................h.h.......................u.Cs.......ChG.t.................t...ht.....................................h.hs.h.ossRNF.sR....t.........s...ph......LsSs.hssshAlhG.....................................................	0	1274	2607	3544
+1082	PF00694	Aconitase_C		Aconitase C-terminal domain	Bateman A	anon	Pfam-B_224 (release 2.1)	Domain	Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism [1].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.54	0.71	-4.04	18	9126	2012-10-01 19:37:30	2003-04-07 12:59:11	14	28	4295	33	2735	7034	4256	118.60	33	21.91	CHANGED	hshalphcGhssstthSsssschth.tphpsshsphtlssthhtshchspspph.st-ps.......shhtss.tY+.tsscllVluscNaGsGSSREHAAhu.pthGh+ulIucSFucIacsNLhppGlLPLphsps	....................................................................................h...ah..pGh.h....t.....s.sspct.h..h.hh.tp.h..sp...hth..t..s....t....h..h...............s......h..........c........h......................t.....t.............................................................................shh.s..t.pY...p........s.s.s.l.........llhu.csaG....sGSSREaAAhuhp.hh.G...........l+sVIA....p..........S.....F.u.cI.ap...sNhls..G.l.L.Plph.t.s..................................	0	835	1673	2276
+1083	PF01756	ACOX		Acyl-CoA oxidase	Bashton M, Bateman A	anon	Pfam-B_598 (release 4.2)	Family	This is a family of Acyl-CoA oxidases EC:1.3.3.6. Acyl-coA oxidase converts acyl-CoA into trans-2- enoyl-CoA [1].	21.40	21.40	21.50	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.98	0.71	-4.92	37	1066	2012-10-01 23:33:27	2003-04-07 12:59:11	14	21	433	8	692	1082	31	165.80	23	25.84	CHANGED	chpss.tshlcAachhstchlpcuspphpp..t.t.s.tpuaspsu.hphhpsu+hHs+hhllpsFhc+ls.....thsstsl+thLppLspLa.uhahlpcpuutFLptuhh..ospplshlpp.tl..cLhsplRsssluLsDuFshsDhhLNSslGpaDGclYcshachsppssssp...tscssaacph..LcPhLp+.	..................................................t.hhpsaphhtt.thltpssp.plp.p...........t..t.t....s.t.hpu.aN.p.st...hphh.....ph.u.pAHsch.hllct.Fhctlp...................ptsss.shpplLppLspLa.uLt.tl..pp.....p..............hu..tal.....pt........s........hl.......os.pp.......h.p.....t.lpp....tl..pLh.spl.....RPp....Al.sLVDu..FshsDhh.LsS........s...............lGt.D.Gph...Ytthht..h.t...............................t....................................	0	256	392	581
+1084	PF00873	ACR_tran		AcrB/AcrD/AcrF family	Bateman A	anon	Pfam-B_578 (release 3.0)	Family	Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer  membrane channel TolC. The structure shows the AcrB forms a  homotrimer [1].	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	1021	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.68	0.70	-13.50	0.70	-7.15	16	19835	2012-10-02 18:57:54	2003-04-07 12:59:11	14	33	3142	84	5307	18191	12148	888.80	26	97.07	CHANGED	hspFFIcRPlFshllAllIhlsGslulhpLPVstaPpIssPsVpVsssaPGASscslpssVTpsIEpshsGlcGlphhoSpS.usGpsslTlsF-pGsDhDhApspVQs+lptApspLPpsV.pp.ulsshcsups.lhshulsSs.......ssshsth-LpsasssslpstLuplsGVG-VplhG.sphuhRIhlDPs+LsphpLThsDVhsAlpspNspluuGpL......sspphphslhspsphpos--accIll+......stsGu.VRL+DVAcVElGu-phshhuphNG.cPAsslslphtsGANsl-sucuV+pclscLpth..hPpGlclshsYDsTsalcsSIcsVscTLlEAllLVhLVhaLFLpNhRATLIPslAlPluLlGTFulhthhGaSlNsLThhuLsLAIGllVDDAIVVVENlpRhltp.puhsP.........hcAshcuhsplptAlluhuhlLsAVFlPhhhhuGssGtla+pFulTllhAhslShlVAlTLoPAlCAhlL+stppscct...........thathFNphFctssptYscslstlL+psthhlllhllllsu.slhLasplPpsFlPppDpGhhhstlQhPsGsShppopplhpplpc.hlp.cpspVcslh.shsGhs..uG..pu.NsuhsFIpLKPhcER.t.pp.ostullp+hptphspl.suslhh.hss.slpt..htsssGhchplts.hhGsuh-sLppstpplhthhtphPs.L....scV+sstpsstPphplclDc-+ApplGlsls-IspslpsAhGu.phlssFhcpuRhhcVhVpsssphR.sP-slsplhVpsspGp.....hlPlouhAohc.shGssplpRhNuh.shpItups..ssGhSsGpAhpshpplhpp..LPsGhshpaoGhuhppptussptshlhslulllVFllLAAhYESashPlslhlslPLullGALLAhhlpGhs.slhstVGllsLlGlusKNAILlV-FAp-hhcpcGhslhEAllpAs+hRLRPILMToLAhlLGhlPLAluoGsGutsppslGhuVhGGhlsuTlLsLahlPlhYlllc	..........................................................................................................................................................................phhlpp..hh.sh.l.ls.l.h.l.h.l.h.G...........h...........h......u...........h...........h.p..........L.....s..........l...p.t.h.Pp.ls..s.l.l.p.s.s.a.PG.A..........ss.pplpppVstslEp.t.h.s...s.l.s..s..l..p.....h..p..S..pS..ptG....u..ls..l....p....F...p.........s.....s...s.........s...h...A...t..........p...V.....pp....tl....p...t.....s...........t.....s...p.....LP....p....s...l...tps.s..l...t.......................p.....s.......s....s....s.......l.h..h.h.sl.hup...........................................................t.h...s........t...p......l...p...s...h......h...p....lp..pl.p.p.ls..G.Vu.p..l.p.h...h....G..t.t.p.hthpl.ls.s..ppLtth.s......l..o..........s.c.l.h....s.u........lps..p.N.h....p..h..s..s..G..tl...........................................pttt.h..p.h....l.p.s.......p.s...........p.....h.......p....s...........h.c....c.....h..tpl..hlt...........................tt.s...G.......s.......................l.p.....LtD.............l...A.p.l.................p......h.............G....................s..............p.............p...............h.............p................................h................s................t.........................h.......................s....................G........p..................................u............s..s.......l.s.l..h.h.t................s.u.u.N.s.lp...s..s..ptlc....t....t...l.t....p....l....p..tt...............h....P.........t.............u.........l.........p............h...t....h.....h...h....D...p.o......h..l...p.....t..u...l...p...p.l.h..p....s.....L....h......u.h....h....l.....V...h..l....V.h....h.l.F..L...t....................s....h...R...u....s....l..l.ss.l....u.l..Pl..sl..l...s.o...h..h..h..h....h..h......h......G......h......o..l.N..h....l...o....L...h..u..l.s.lA..lGh....lVD.DA.IVl.l.E....N....l......+.h...hpp.....s.hss...................................................................hp.A.s.hpuhpplshsl.lu..hsl.s.lhs........VFlP.l.h.h..h..s...G...h...............s.G..t....h.a...p..t.hu....holsh..uh.hh....Shl..lul.s..l.s.P..h........h......s.....u.......h.........h......L...+........t....t..t.tpp................................................................................s.......t.....h...........h....p........t........h.....t.....p...........t.....Y......t.......t....h...l.....t......h...h......l......p.......p.......p....h.................h.......h.....h...h.....h....h........h..............h.........h.....h......sh........s.....h.....h................h............h........h........h...............l......s.....p...................p........F..h...P...p..pD....p..u............h....h.....h..h.ph.s............us...........o.......h..pp.s...........t.p....h.h.......p.p.......h..................p.......p.......h.........l..............t.........p....................................s.........t.............l.......p..............p............h............h.....s.........h........s........G..........h.........s.......................s..........s..................................t..........s................s.................u...............h......h.......l.........t.........L....c....s....h.....p......................p..................R..........................................................................t...............................s.............h...............p......t...........l..........h...t................c................h..................p.t.........t......h.................t..................p..........h.....................s..........s.t............h................h.........h.......h.................t.h..h.............................s..s.u...h.......p....h....l........t...........h....h.h.u.........s...h...p.t.Ltp...h.s..p..p....lh...t......h...h........t......p........s..t...l..............ss...l...p.....s..s.....h......t.....t.s......tsp.hplplD..p.ppAtth......Gl..sh.ss.l.s.p....s....l.....................p..s..s......................h...u.u....t..........l...........s...........p.....h....h.....p........t....s..........p...............h...p...l....h....l..........p..................h.........s.............t........p...........................R................s...................p.........s...l..p....p...h......h.....l.....t.....s....s...s...G.t....................................................................h..l...P...L...ush...s...p...h.p.....t...u.s.s.t.l.p....+..h...s.th..s..h..p....l.tu..sh.....................s.s...s...............h............s.....h........u.............p.......s....h................p........h......h............p........p..........h............h............p.................p......................................................L..............P......................s.....................G.....................h................t..................h................p................a..........s..................G.......t...s...........p.......p..p....u....h..............s.............p....h..........h...........h................h................h..sh.u....l.lhla.ll.Ls.................h..............a.c.S...hh..P.hh...lh.h...s.lP.hu..ll..G.........u.........l...........h..............u..l......h............l...............h..................s...............h......................s......................h...........s.............l............h....s........l..G......h.lh.L....h...Glss.+NuI.ll.......l........-.....a............h........p..........p.........h........h...........p..............................p..............G.............h..............s.............h...............h.............c............A.....h....h.....p.A.shhR.hRPIlMT.sh.shlhGhlP.l.............h............h............u..................t..................G...............s...............G.........u.t...h..p.............p.......s.......luhslhGGhlsuTlLsLh.h.lPs.h.ahhh................................................................................................................	0	1569	3236	4342
+1085	PF05058	ActA		ActA Protein	Moxon SJ	anon	Pfam-B_5981 (release 7.7)	Family	The ActA family is found in Listeria and is associated with motility. ActA protein acts as a scaffold to assemble and activate host cell actin cytoskeletal factors at the bacterial surface, resulting in directional actin polymerisation and propulsion of the bacterium through the cytoplasm of the host cell [1,2]. 	23.80	23.80	31.70	23.80	21.10	22.90	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.74	0.70	-13.05	0.70	-6.52	2	1025	2009-12-16 10:43:18	2003-04-07 12:59:11	7	3	37	0	1	762	1	335.50	65	99.41	CHANGED	MRAMMVVFITANCITIsPDIIFAsTDSEDSSLNTDEWEEEKTEEQPSElNTGPRYETsREVSSRDIKELEKSNKV+ssNKADLIAMLKtKAEKGPN.NNNN...SEQotNsAINEEASGADRPslQVERRHPGLsSDSAAEIKKRRKAIASSDSELESLTYPDKsTKsNKKKVAKESlsDASESDLDSSMQSADESoPQPLKANQQPFFPKVFKKIKDAGKWVRDKIDENPEVKKAIVDKuAGLIDQLLTKKKSEEVNASDFPPPPTDEELRLALPETPMLLGFNAsATSEPSSFEFPPPPTD...................................sELEIhRETASSLDSSFTRGDLASLRsAINRHSQNFSDFPPIPTEEELNGRGsRPTSEEFSSLsSGDFTDDENSETTEEEIDRLADLRDRGTGKHSRNAGFLPLNPFsSSPVPSLSPKVsKISAPuLlSDITKKsPFKNPsQPLpVFNKKTTTpTVhKK.TPVphAPKLApLPsTKPQETsltENpsPhhEKQAETNpQsIsMPSLPVIQKEsTEpsKEEMKPQTEEKMVtESEsANssNGKpRSAGhEEGKLIAKSAEDEKsKEEPuNHTTLILAMLAIGVFSLGAFIKIIQLRKNs	.....................................................................................................................................................................D.LIAML......KtKAEKGPN.NNNN.....uEQotNsAI.N..EEASGsDR........Psl.QVERRHPGLsSDSAAEIKKRRKAIA.SSD.........SELE......SLTY..........DKPTKssK+.K.VAKtSVsDsSESDh.....tSphpSsD.ps....KtsppPFFsKsFcKIKtAGpWshDKlscNPt....................cpEEVNAS.DF..P..PPPTDEE....L......R...LAL.PE.TPMLL....GFNA..........P.ssSEP....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+1086	PF00976	ACTH_domain		Corticotropin ACTH domain	Finn RD, Bateman A	anon	Pfam-B_1057 (release 3.0)	Family	\N	20.70	20.70	21.10	21.00	19.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.14	0.72	-4.11	13	1273	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	737	0	33	1256	0	38.60	83	21.34	CHANGED	SYSMEHFRWGKPsGRKRRPIKVa.sNuh..E..-ESpEsaPhEh	..SYSMEHFRWGKP...V.G.KKRR..PIKVF.PoDA...E..EESSEhYPhE.h..............	0	1	4	13
+1087	PF00022	Actin	actin; 	Actin	Sonnhammer ELL	anon	Prosite	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	393	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.26	0.70	-6.05	28	15168	2012-10-02 23:34:14	2003-04-07 12:59:11	14	83	3849	392	3857	12329	1523	241.30	43	92.30	CHANGED	u--lsulVlDsGotss+AGaAG-DsP+..........slhPohlG.....+spsst......................................chhlGsp...thp.....csthplppPh.ccGllpsW-shcclWcashhpc.Lpss........P......................................p-+PlLlTEsshNspppREKhsElhFEpapsPAhalupssVLotaAsG+s..................TuLVlDsGsupTslsPVa-GasLp+ult+.sluGchLoppl.ppllpp.......h.h...........h...........................s.SapshtcppllpchKEslChVs.s....................phptus...........s.ssps......Y....cLP.DG...............................................p..phhhGs-RFplsEhL.....FsPshht.ptt................................GlscllhsulttsD..sDlRtsLhuslVloGGooLhsGhs-RLppElpph................s.ssh.....+l+lhAss...ER+ausWlGGSILASLu.oFp.phWlSKpEY-EpGss...lVc++Ch	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....................h...t.h.......................................................................................................................................t..p....p...........h....l...l.........o...E.s.............s.........h.........s.........s...........................t...p...R...c......p...............h....s..........p........lh......F..E.....p.a.s......h...s.u.....ha.l.......sh..pu..l.L.....u..l.....a...u...s..G.p.s..........................................................................................o.G..l.Vh..DsGcu..so...p.s..lP.l..h...-......G........h........s..l...s...p..........u...l......h......+..l...s......h.........u.G.c..c.lTp.hh.hplL.tp.......................p................................................................................................................................................................t...h.....t.....t.p.h..cl..l...c...p...h...K.....E...p..h..s..a.l.u.shpt.....................t.t..ts.........................................................................s..t..p..p.........a..........p..l....P...D...G..........................................................................................................................................................................................................................................................................p.......hl..p..l..u...t...E...R.a..p....s..s...E....hl............FpP.p...hs....p...........................................................................................................ul........h....h.h..p.....s..l..............p.......s...s................h.-....h....+....t.....t...l.h............t.s..h.lh....s.G.G...s...o.....hh...........s....h.........tRh.......tch.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1405	2078	3077
+1088	PF01643	Acyl-ACP_TE		Acyl-ACP thioesterase	Bashton M, Bateman A	anon	Pfam-B_928 (release 4.1)	Family	This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via  hydrolysing an acyl group on a fatty acid [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.67	0.70	-5.45	27	1578	2012-10-02 20:54:35	2003-04-07 12:59:11	12	8	1264	3	365	2638	846	228.20	24	89.64	CHANGED	GLsa+psFslRsYElGhs+TAolETlhNhLQEsuhNHspslGh.sDGFutT.pMp+hsLIWVVs+hplplpRYPsWGDsVcl-TWstupGKhGh+R-WhlpDhpsGEllsRAoShWVMMNpcTRRLs+ls-EVRsEh.shh.pp..l...--sscKLpKl......-ssu-hhctGLsPRasDLDhNQHVNNVKYlGWlLES.hP.pll-o+ELpslTL-YRRECtpDsllcSlTsht......................sstppsthphpHlLplss......GsEIs+u+T-WR.	.........................................................................................ap.phpl.h...csD.hs..t....p..hpl....sslhphh......p.sut...p.s.t.p.h.G.hs..ph..........hpchsh..sWl.lschplcl......p.R.h.P.p..h..........s.-.p.lp.lpTh.s.h.u.h.s..+...h..a.s..h..R.c.a..t..l...h....s......p.s......G.........p...............l.s.cspoh...alhhshco...R.....+.h...t..p...l..s...s....-.lh.s.a.....................tsp.....p.+lh.+h.h.........hpt..p.p.....h.t.ps.a..p...l..Ra...D...lDhNtHVNN...........sc...Y........l........p........W.......l.........h........-........s..........h....s.........h.......c.......h...........h........p.........p............t..........t.....................p....p...........l.........p....l.........c..Yh+E.s.t....Gs......lp....................................................tt......h...l............t.............h...a..........................................................................................	0	116	276	331
+1089	PF02770	Acyl-CoA_dh_M		Acyl-CoA dehydrogenase, middle domain	Finn RD, Griffiths-Jones SR, Mistry J	anon	Prosite	Domain	Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold.	20.60	15.00	20.60	15.70	20.50	14.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.35	0.72	-4.45	69	26220	2009-01-15 18:05:59	2003-04-07 12:59:11	14	120	3313	214	9308	22756	9383	53.90	34	11.57	CHANGED	uhuhTEss.uGoDh........tshpTpAptssss.......ahls.....GpKtalos.u..shA....shhllhu+s.s	............................................shuhTE..P....s...uG..S..Ds.................s.u.l.p.....T..p..Ap..p.......su-t...................alls..................G.p.Kh...aIos...u......shu......s.h.hlVhA+s......................................	0	2632	5550	7773
+1090	PF02771	Acyl-CoA_dh_N		Acyl-CoA dehydrogenase, N-terminal domain	Finn RD, Griffiths-Jones SR, Sammut SJ	anon	Prosite	Domain	The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha  domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.79	0.71	-3.50	988	26175	2012-10-02 12:47:07	2003-04-07 12:59:11	11	97	3435	215	9054	22885	10305	112.70	20	25.73	CHANGED	o.-.......-pc..hl+cs...sRc.Fspc..cl.h..P.....h........stch.....c..c....pp.p.........hP...tc..l..hcch.u.-.h.GlhGlslP......E-YG.G...s.G..h.............s...hhshsllhEElu+..ss...s....uhsh.hhss..pssls.s........l....hpaGo.--QKp...+..aLPtlssG-	.............................................................p.p.hhp.t....scp..ahpp......pl...t.....s.........h...............................h.tph.............-.......c.............ps.....p.........................hP..........pc....h..........h.p.ph...s....c....h....G.h.....h.....u...l....t..l....P...............................cc.a......G.....G...........t..G.......h...................................s...hhp.hs.l.l.h.-El.up.....ss.................s.....u.hsh.......hhss.....t.s.s.ls.h..........sl..............ht...aG.o...c.c......Q..+p...c.a.LstlhpG...................................................	0	2413	5396	7525
+1091	PF02551	Acyl_CoA_thio		Acyl-CoA thioesterase	Bashton M, Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	This family represents the thioesterase II domain.  Two copies of this domain are found in a number of acyl-CoA thioesterases.	20.70	20.70	21.20	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.75	0.71	-4.53	9	1320	2012-10-02 20:54:35	2003-04-07 12:59:11	10	4	888	10	170	2384	900	124.10	41	59.06	CHANGED	hssthFhs-h..p.css.hppsasGphhu...Qshhtu.p.ssP.cDhhlppsh................................HShaFh+sscsschllYslpo........LtpGchF.......sQsGplluo......sspcGh	.........................................................................l.pttFhs-pPhchcP.s.h+.p.s.h...p...GcV.st....pQ..lWl...+...AsG...sl.P....D....D..h....hlH....p...ah.LuYuSDh..sh.Ls.s...A...l.......p...s...Hsl..........uhhp...t.h...p....l...AT..l..DH..S..h..WFH.....R.........P.........F......s........h........s.-W..LLY.............u.VESssA..u..s.uRGhsR..G..cha.......sQsGt.LlAo.......ssQEGl.........................	0	28	69	120
+1092	PF00698	Acyl_transf_1	Acyl_transf; 	Acyl transferase domain	Bateman A	anon	Pfam-B_250 (release 2.1)	Domain	\N	24.30	24.30	24.40	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.84	0.70	-5.10	12	13987	2012-10-02 11:19:24	2003-04-07 12:59:11	16	1271	5013	68	4402	12759	2619	292.50	26	23.26	CHANGED	VaVFsGQGuQWtGMGhpLlpspslFtsultcs-cshps.hGaplh-lLp..sss.......................................................thcpl-hlQPsLhulpluLsplh.puhG..lpPsuVlGHShGElAAuhVsGALo.t-ushslshRuphhtpls.stGuMsuVsh....s..c.h.t.h.splslAssNuPpollluGsp-tlp-hlpphptcs.htsphlsVshAsHSsphsslt-sLtttLup.lsshtsplshauospss.t.....sssphsApYWhpNh+psVpFppAlpuh...h-suatsFlElSsHPlLttulpcshc.........tshssssllsphpRcpss...hppFhtshsphHssGsss	...............................................................................................................h.alFs.G......QGu.Q.hsG....MG.p.p......Lh....p........p...........s....s....ht....p.....s....h....s....p........s....s...p...h........h.......t.....................h........s...........h.........s.......l...h...p....l..lh......s.s..s..t............................................................................t.t.L..s..p....o...p...h...s....Q.P....A.....l...h....s...h....p....l....A......l..h..c....l....h.....p....s.......h.......G.............lp.P...s...h...l....s....GH....S........l......G......Eh........u..Ah.h.....s.AG..........s..........l..o.h...p.....D.....A.......h....p........lV.......t.....h.....R.......u....p.....h........h...............p................p.............h.............s........s...........s...........G..........u.......M...s..A...lhs................................stt..t.....h....h...............t.......h........t...........s......t....................l.......s.......l.A....s.....h.....N...u......P...........s..p...........s............V..lu..G....s.t....p...u..........l....p.....p....h....h.......t...t.............h........p.........t........p............G.......h.............p.s..h...h........L....s..V.......s.h..A....h.H.o.s.......h.h....c.s........h....t............p...p......h.........t.....p......h.....l......t.......p.........l..............p.........h.............p.........s............s.......p...........l........s..........l......h....o....s...l..s...u.p.hh..............................ss.s.t.h.......t....p.h..h...h...c...p..lt...p...s.V...p....a....t...p....u.............l...........p..................th...................h..............t..............t..............G...................h...............p................h.................h..........l.................E...l..uP.t......s...L...t...t..hh.p...p......................................................................................................................h.........................................................................................................................................................................	0	1131	2658	3767
+1093	PF02273	Acyl_transf_2		Acyl transferase	Mian N, Bateman A	anon	Pfam-B_5787 (release 5.2)	Domain	This bacterial family of Acyl transferases (or myristoyl-acp-specific thioesterases) catalyse the first step in the bioluminescent fatty acid reductase system.	20.30	20.30	20.30	20.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.94	0.70	-5.40	4	59	2012-10-03 11:45:05	2003-04-07 12:59:11	10	4	39	2	8	132	21	269.20	60	83.59	CHANGED	hsIDHVIcVsssRcI+VWEThPKppssKRNNTIlIASGFARRMDHFAGLAEYLSpNGFHVIRYDSLpHVGLSSGpIDpFoMSlGKpSLLTVlDWLp.p+sIsNlGLIASSLSARIAY-llu-lsLSFLITAVGVVNLRsTLE+ALtaDYLph.IDElP-DLDFEGHpLGScVFVpDCFEssWDoLDSTINKhtpLslPFIAFTANsDDWVpQcEVhcLlSsI+Sc+sKIYSLlGSSHDLGENLVVLRNFYQSlTKAAIAhDsshl-lss-IIEPsFEpLTIATVNERRLKscIEs	...........................................sI-HVlplsssppI+VWET.PK...pp.sp+psT.IlI.A.S..G....FAR..R....M.D.....H......FAG......LAEYLSsNGF..HVlRYD..SL.pH..VGLS.S...Gs....IspFoM.S.l...G.K...p..SLhsVl-W.Lp...s+...G...l..p..p..lGLIAuS....L.S.A..R...I..A.Y.-...l.su.-.l..s.LSFL...IT..AV.GV.V.NL..RsTLE+ALtaDY...Lp.h.Is-lPpD.LDFE.GHpLGScV...FVpDCFcppW.DoL.-ST.ls...chppL.slPFIAFTANsDsWVcQcEVh-hlusIpSs+sKlYSLlGSSHDLGENLVVLRNFYQSVTKAAIALDss.l-lss-h......l..EPpFEpLTlsTVNERRLKscIEs...........................................................................................................................	0	2	4	5
+1094	PF00708	Acylphosphatase		Acylphosphatase	Bateman A	anon	Pfam-B_686 (release 2.1)	Domain	\N	20.80	20.80	20.80	21.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.99	0.72	-3.88	75	4748	2009-01-15 18:05:59	2003-04-07 12:59:11	13	31	3398	34	1333	3407	353	90.30	31	29.81	CHANGED	M...............hphplhlpG.pVQ..GVGFRhastphApphG.lpGa.VpNhs-G...pVclhspG.spps.lcphlptlpp..ussh.....uplpplph.pphshpsp........ssFpIt	.........................phphhlpG..+VQ..GV.G....F..R.h..h..shphApplu.....LsG.h....VpN...t.sDG.........pV-lh....s.p......G.sp.pp....lcph....l.p.t....Lcp....usss.......A+.V.splph...p...h.p.h..p..tt......ssFpI.......................................	0	404	800	1089
+1095	PF01553	Acyltransferase		Acyltransferase	Bateman A	anon	Pfam-B_128 (release 4.0) & Pfam-B_5069 (Release 7.5)	Family	This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [1].  This family also includes tafazzin Swiss:Q16635, the Barth syndrome gene [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.90	0.71	-4.71	57	17338	2012-10-02 00:16:30	2003-04-07 12:59:11	16	145	4819	2	5587	13699	5618	134.80	20	34.96	CHANGED	plplps....Epl.p..................ttssllluNHpSh...lDshhls.hhh...........pshhhlupcplhth.shhshhhp....hhsslhlcR.............................tp.pttttshpthhc...hlppG................ph.lhlFPEG.....Tcsps...................tph..h.aKpGshphshps.......sssllPlslp	..........................................................................................................h...h.s.....pp.l..p..................tts.h.l..l.l..u.N..H.pSh.............hD.h..l.h....l......s...hhh.......................................t..h.ph.h..u...c..p...p...l.....h......p......h...s.....h....h.....u.....h....h.hp.................hh.s..s.l.......l..c..R.................................................................................................................tt...t.t..s..t...t..s.h.cphhc.........hl.pp..u.....................................................................................ph...lhlF...P..E...G................o.+.sps.............................................................tph.......h.h.+.s.G..h.h..th..uhps......................sssllPlhh......................................................................................	0	1763	3288	4613
+1096	PF02805	Ada_Zn_binding		Metal binding domain of Ada	Bateman A	anon	Bateman A	Family	The Escherichia coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue. This domain contains four conserved cysteines that form a zinc binding site [1,2]. One of these cysteines is a methyl group acceptor. The methylated domain can then specifically bind to the ada box on a DNA duplex [2].	20.90	20.90	20.90	21.10	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.24	0.72	-4.38	150	1999	2009-01-15 18:05:59	2003-04-07 12:59:11	11	24	1681	5	495	1548	76	64.90	47	18.48	CHANGED	-ppap.AlhsRD..spaDGpFahuVpTTGIYCRPsCsuRhP+ccNVpFasouttApsAGaRPCpRC+P-	.....................................ppap.AlhsRD..sphDGpFhhAV+TTGIaCRPSC.s......u......R..t.......P..p...c......cNV....p...FassAspAhsAGFRPCKRCpP-.........	0	126	281	399
+1097	PF01602	Adaptin_N		Adaptin N terminal region	Bashton M, Bateman A	anon	Pfam-B_491 (release 4.0)	Family	This family consists of the N terminal region of various alpha,  beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles [1]. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family[2]; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles [2].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.50	0.70	-6.18	32	3862	2012-10-11 20:00:58	2003-04-07 12:59:11	15	87	445	26	2500	4196	107	460.30	19	58.89	CHANGED	cpphhpp-ltphhsph..............s.p....p+ppslpKllhlhhhGp...chs.....hhhhsll+hht.opchshK+lsYLhlh.hscppsD.....lhhL...sssslp+D.lp...ssNphhpuhALpsLuslt..sscls..csltsslpphls.spss..aVR+sAslshh+laph.....ss-hlpp....hsclpchl..sDps..........................hVhtsAlshltcl...................pssc.hh....cllthhhppltph....................s.sssahplhllchL.p....phstpsspts...........................................................................t.hhcplhshlp....................ssssuVlhEslpslh........plsspss........hhhhssshLhphLs.spcpsl+YluLps.lsplspp..........c.....pslh..cpshhlhhlp.csshsl+hcsl-lLhtlsscpNlpp...llpcLhpa......l....-ht-.p................a+pthlpsItplu.+h....ssshphhlssLlcllp.....ps..shh..sp-hl.slhpllpphsshpths..lppL....hchlps............hppsp.......h..htshlWllGEaushlss.................ssphlcplhpphh.pss.l+tt.hLsshhKht...........httst.pht.............plhphlhphsp..s.ch-lp-RAh..........hhpllptsp	................................................................................................................p.tt.hpp.....................p.t.....hptp.h.lt+.ll.................h.hh............h.h.G........s..hs..................h.h.phlp..hh.....t...s...pphp...K............+.l.......s...............YLhh..........hh..p.......p.p.-..............................hhhL..................ssssl.p.p......D..hp.........................s....s.....h....hp.uhA..lp..sl.s..p.lt...................ssp..hh............p..l....h...l..t.p.h..lt....s....t...s....s.......hV++p.A...sls..........h..h+l...hph.................................ss.p...h...h.......t.........hs.p....l..h..p.........hl......s-.ps..................................................................................hV.h.hs..u...l.sh...l...hpl........................p..sp...............phh....t...h...h.p.t.....l.th....................................................................................s.h.s...a.h.plh.l.l.c....h.l.t.............t.h.s...tp..ttt........................................................................................................................................................................................t.hhp..lhshlp.................................sts...tuV.l.h...pshps.lh......................................................ph..s.t..s.............................hhth.hs.s...Lhphl........p....sp..............p...p.............l.p....al...u...L..ps..lttl..h.tp............................p..............sl.........p..t...p...h........l......h...l....p...........ss..s.h.....l..+......h.t.....t..l....c.lhh.t....h...s........s...p.........p..N..l.pt..............l......l.p.....c..lh..p..a...................h............p.h...-.p.............................................htt..thl.pt..l.t...t..h..s..ph..............................s..sh.phh.......l.s.h.l.hp..l..l.p..............................ts.......s.hh.......hpph..h...l...h.p..l..h.........p.......p......................s........p.......h......p........t............h...............l.t...p....l..................h.p..h.l.pp.................................hp....p..............................h..htshh..a.llG.E..a.u....phh.p.................................................................................s.ph.h.p......h.....h....p..t.....h...h........p.....s................s..p..h.....hlsshhKhh.........................................................................................................................tlh....h.l..th.t........p.s.-.........lppRuh....h.tlh....t.............................................................................................................................................................................................................................................................................................................................................................	0	926	1396	2042
+1098	PF03352	Adenine_glyco		Methyladenine glycosylase	Finn RD	anon	Pfam-B_3953 (release 6.5)	Family	The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA. 	25.00	25.00	29.60	25.10	22.80	24.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.14	0.71	-4.75	190	3641	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	2986	18	794	2600	430	166.00	41	85.63	CHANGED	Ws....ss......slYhpYHDpEWGhP.lp.DDppLFEhLsLEGhQAGLSWhTIL+KR-saRpAFssFDsppV...Apa.....s.-pclccL.htssGIlRNRtKIcAsIsNA+shlplpc..ch.....GSFusalWsFV.sspP.hhsp..hpshtclP.....u..pTshScslSKcLKKRGF+FVGPThsYAFMQAsGhVN.DHlssChpptp	....................Ws..tps..slYhtYHDpEWGh...P..p...D.-.ptLFEhLsLEuhQAGLSWhTlL+K.....Rcsa....RpAFts.FD.p+V.......Ath........s.-p.-......l....-c.L..h.p.s.s..uIIRpRtKIpAslsNAp..uhlpl.....pp..........p.h...................G.SFssalWuF........l....st.ps...hsp...ht..s..hp..p..hP......................s..p..o..shS.ctlSKsLKK+GF+FVGsThsYuFhQA.....sGhVs.DHh.sC.hh..t............................................................	0	218	478	659
+1099	PF02438	Adeno_100	adeno_100; 	Late 100kD protein	Mian N, Bateman A	anon	Pfam-B_1583 (release 5.4)	Family	The late 100kD protein is a non-structural viral protein involved in the transport of hexon from the cytoplasm to the nucleus.	25.00	25.00	131.30	131.10	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	583	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.87	0.70	-6.30	19	136	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	100	0	0	144	0	588.50	65	76.54	CHANGED	ssLhKHlpRQutIl+puLp........-p.psPhoVsplSpthEptLFs......P+sPsc+pcNuos-PsPRLNFYPsFhlPEsLATYHIFFhNppIPlSC.+ANRotuDphhpLppusplsslsshccssKlh.-GLG.pEspusst.Lp........psutLVpLcsDssRLsslK.RshploaFAYPAlsLPPKl.pslh-pLlh+psp...........pps-sscPVVSDEpLs+Wls.ss.......-st..tLp......c+..RKthhuAlhhTlpLEChp+hFoc.phl+KlpEsLHYTF+HGaV+.spcIosVpLSNhVoYhGlhHENRLspssLHsoLcuEs+RDYlpDolYLFLlaTWQTAMGlWQQsL--cNlcplpclLs+p++sLasthspcslApcLAcllFPtc.LlpThppuLPDFhoQS.lpNFRoFILERSGILPuhssALPSDFVPlsa+EsPP.LWsHsYLLpLAsFLhhHuDhh......EDsuspslhcsaCcCNLCoPHRslspNsuLhNElpsIGTFElQsPsspsst......LKLTPuLWssAYL+KFsspDYasapItaYcspsc.s.pspLTACVITpscILApLppIpcuRE-FLL+KG+GVYLDPQTGEpLN	..DVLLKHLpRQShIl+DALt.......DRocsPlSVcELScAYEhsLFS......PRVPP...KRQsNGTCEPNPRLNFYPsFAVPEALATYHIFFKNQ+IPlSC.RANRoRADtlLsLtsG.uRlPDIsSLEEVPKIF.EGLGpDEsRAANA.Lppp...........ctppSsLVELEGDNARLAVLK..RolElTHFAYPAlNLPPKVMpslMDpLlhp+spsLsc......pptpps--ucPVVSDEpLuRWLG.Tp.......-Pp..sLE..........cR..RKLMhAsVLVTlELECh+RFFoDP-TLRKlEEoLHYTFRHGaVRQACKISNVELoNLVSYhGILHENRLGQsVLHoTL+GEARRDYlRDCVaLFLsaTWQTAMGVWQQCLE-pNLKELcKLLpRshKsLWTGFDERTVAuDLA-IlFPER.LppTL+sGLPDFhSQSMLpNFRoFILERSGILPATCsALPSDFVPLoYRECPPPLWSHCYLLpLANYLuYHSDlh......EDVSGEGLLECHCRCNLCoPHRSLsCNPpLLSETQlIGTFELQGPpssst..us.........LKLTPGLWTSAYLRKFlPEDYHsHEI+FYEDQ...Sc.P..+A-LTACVITQusILAQLpAIQKuRpEFLLKKG+GVYLDPQTGEpLN......	0	0	0	0
+1100	PF03052	Adeno_52K		Adenoviral protein L1 52/55-kDa	Mifsud W	anon	Pfam-B_2151 (release 6.4)	Family	The adenoviral protein L1 52/55-kDa is expressed in both the early and late stages of infection which suggests that it could play multiple roles in the viral life cycle.  The L1 52/55 kDa protein interacts with the viral IVa2 protein and is required for DNA packaging [2][3]. L1 53/55-kDa is required to mediate stable association between the viral DNA and empty capsid [2].	25.00	25.00	47.20	46.80	21.70	17.90	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.11	0.71	-5.09	18	154	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	99	0	0	150	0	187.10	52	54.87	CHANGED	lsp.ssuhAsct.......h.+.Qhcc-shcutlPppNlF...R-tpsp.....-t.RchhapuGptlphsh..cRsLpscDF....s-.s.....ulSsApsHhpAAcLtpsactTtphEsshpcoFsscl+sLlhR.ElslGLhaLhDFlpshhppPs.shsLssQLhLlspHscscsshRctlhslucsc......ucWLhDLlshltsIl.pccphsls-pVuAIs	...........htph.....GA.uPER.......HPRVQLp+DsRtAYVPtQNLF...RDcSGE...EsEEhRctRFcAGREL...R..L..DR..pRlLRsEDF..EssE.o......GlSPARAHluAAsLVoAYEQTV+pEpNFQKSFNNHVRTLlAREEVslGLMHLWDhhEAhlpNPs.SKsLTAQLFLlVQHSRDNEsFREALLNIuEPE......GRWLhDLINILQSIVVQERuLoLu-KVAAIN.........	0	0	0	0
+1101	PF02703	Adeno_E1A		Early E1A protein	Bashton M, Bateman A	anon	Pfam-B_1193 (release 5.5)	Family	This is a family of adenovirus early E1A proteins.  The E1A protein is  32 kDa it can however be cleaved to yield the 28 kDa protein.  The E1A protein is responsible for the transcriptional activation of the early genes with in the viral genome at the start of the infection process as  well as some cellular genes [1].	24.90	24.90	24.90	25.50	20.90	24.80	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.11	0.70	-4.95	15	313	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	91	4	0	292	0	158.20	37	97.87	CHANGED	MRplhhhssh.h....-hus-lLE...plVsshhss-hPp.ssshhpsPSLHDLYDLE..V-ssE.DsNEEAVsshFsDuhLLAAcEu......................sssh.ssppssGspslP-L.ps--hDLpCYE-GhPPSDsEDEpppp..shpphuspushshppt.......FhLDsPplPGHGC+SC-aHRpsTGssshhCuLCYhRspspFlYSPVSDst..--cosss.........................-pps.........SPPclssssP.slh.+PVPVRsostRRsAV-slED.......LLpE....ssEPLDLSl.KRPRs	....................................................................t.h....p....hlpthh..p..................s.oLp-LYDl-..Vps.p..DsNEcAVs.hFs-uhhLtsp.u........................s......s...s...hPtL.....hDLhCaEtshPsSDsEspp.....................................................................................hSt...........................................................................................................................................	0	0	0	0
+1102	PF01691	Adeno_E1B_19K		Adenovirus E1B 19K protein / small t-antigen	Bashton M, Bateman A	anon	Pfam-B_1569 (release 4.1)	Family	This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell [2]. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen [2]. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein [1].  The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis [2].	25.00	25.00	40.80	40.30	18.20	17.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.31	0.71	-4.87	17	117	2009-09-10 16:39:30	2003-04-07 12:59:11	11	2	86	0	0	102	0	134.60	47	75.49	CHANGED	M-....lhphLpsapphRpllctuSspsShhhRahFGupLuclVacsKp-acppFtclLs-s.GlasuLsLGapshappcllppLDFSoPGRssAulAFlsallDcWs.pcop...lSpsahLDhlshsLWcth...h.p...phhhh	........M-..lWslLpDFppTRpLlEsu..SsusShaWRah..FGos....Lu+LVaplKcDYppEFEclLs-CsGL.a-uLNLGHpuhFpE+ll+sLDFSoP..GRTsAuVAFlsFllDKWs.ppTp...lScGYhLDalAhtLWRsW..h+ppt...hph.....	0	0	0	0
+1103	PF01696	Adeno_E1B_55K		Adenovirus EB1 55K protein / large t-antigen	Bashton M, Bateman A	anon	Pfam-B_1728 (release 4.1)	Family	This family consists of adenovirus E1B 55K protein or large t-antigen. E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site [1].  This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein [1].  The E1B region of adenovirus encodes two proteins E1B 55K the large t-antigen as found in this family and E1B 19K Pfam:PF01691 the small t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.  This family shows distant similarities to the pectate lyase superfamily.	21.80	21.80	21.90	31.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.22	0.70	-6.00	15	139	2012-10-02 14:50:22	2003-04-07 12:59:11	12	2	88	0	0	132	1	334.00	51	78.03	CHANGED	sssshhsp....Lshuhhs+pR.EpVpap-lps-a..pct..hht-+YsFEQlKTahLpPt-.DhEtsI+paAKlALRPsspYpIp+slsI+ssCYIlGNGApVclsspcpsA.Fcsthh.uhsPGVsGMpuVTFhNlRFps-s..........asGslFhusTplllHGCsFhGFssoCl-uhussplRGCpFhuCa+ul.su+s+ucloVK+ClFE+CslGlhsEGpu+lR+Nsuo-ssCFlll+GsuplcHNhlsussch.pps.hpMlTCu..sGpspsLpolHIsSHsR+pWPsFc+NllhRCslHLGsRRGsFpPhQCNhoaopllLEscuhs+VsLsGlFDhshplaKlLRa.--s+sRsR.....sC-CGupHhph.ssshpVTE-lRsD+hhhSCsssEFsSS-E	......................s.pt.hscLshSLMsRpRPEplhatElpp-h..pct..hhppKYuhEQlKTaWLpPt-.DhE.AIcpaAKlALRPDppYplo+plsIRpsCYI.GNGApV.lss.D+sA..FcCsMh.sMhP...G..VhsMpuhsFhNh+Fpuct...............asGslFhusophhLHGCsFaGFNshCl............EsW.utsplRGCpF...........huCWhul.suRsKSphSV.KpClFE+ChLGl..s.EGpuRlR...Hsuu.-ss.CFhLlKGsAslKHNMlpGss-..pp..hphLTCs..sGhCphLtslHlsSHsR+tWPhFEpNllh+CphHLGuRRGhF.PaQCNhspsplLLEs-AhS.RVsLsGlFDMslplaKILRY..DEo..+sRsR.....sCECGG+HhRhpPVsl-VTE-LR.PDHLlhuCsssEFuSSsE...............	0	0	0	0
+1104	PF04623	Adeno_E1B_55K_N		Adenovirus E1B protein N-terminus	Kerrison ND, Bashton M, Bateman A	anon	DOMO:DM04583;	Family	This family constitutes the amino termini of E1B 55 kDa (Pfam:PF01696). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site [1]. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein [1]. The role of the N terminus in the function of E1B is not known.	25.00	25.00	34.80	33.50	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.50	0.72	-3.49	5	123	2009-09-11 22:02:39	2003-04-07 12:59:11	7	3	65	0	0	110	0	68.70	40	17.64	CHANGED	MERsNPoEpGl+uGLHusAsVEuhptuAEEEsL+LLAuAASs.pssussssstAthtuGGus.uuuGGE..Es	...MEstsPspQGl+sGh+upu.VEshttuAsp-NLcLLAusAuh.ts...ss....puss.s.....t.uth...tuGuts..uuuGtp....t......................	0	0	0	0
+1105	PF04834	Adeno_E3_14_5		Early E3 14.5 kDa protein	Waterfield DI, Finn RD	anon	Pfam-B_4148 (release 7.6)	Family	The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm.  It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis.  It achieves this through the interaction with E3 10.4 kDa protein [1,2].	23.60	23.60	23.60	25.50	22.10	23.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.47	0.72	-3.57	8	110	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	68	0	0	79	0	104.20	50	79.38	CHANGED	pC+FpcPWsFLcCYpccoDhsssWlhhlshlhlhssThhultIYPphchGWNuPsAhshPphPs..tthPLQ........PhPpP............-P.PpsPosISYFpLTGGDD	......KCKFpc.WsFLcCYccKsDhPshalhIlGI.lhlhuCT.hFu.lhIY.PpFchGWNuspAhsaP.-Ps..tphP..........Phs.Pht..........pY.pEP.PphPoslSYFpLTGGDD.	0	0	0	0
+1106	PF03307	Adeno_E3_15_3		Adenovirus 15.3kD protein in E3 region	Mifsud W	anon	Pfam-B_3512 (release 6.5)	Family	\N	25.00	25.00	45.80	45.60	20.40	16.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.76	0.71	-4.35	8	100	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	71	0	0	67	0	116.40	64	88.98	CHANGED	DGphoEQRll..phR.tRppp-RpspELtsLhslHQCKKGlFCLVKQAKLoYE.lsu..psHcLuYpLstQRQoFssMVGssPIpVTQQuG-scGsI+CsCcsPEClYTLlKTLCGLR-LLP	..............DGpsSEQRll..QLR.lRQQQERssKELtDslsIHQCKKG.IFCLVKQAKIoYE..lsu..psHRLoYELPpQRQKFTCMVGlNPIVITQQSG-TcGCIHCSC-SPEClYoLlKT.LCGLRDLLP..........	0	0	0	0
+1107	PF02440	Adeno_E3_CR1		Adenovirus E3 region protein CR1	Bateman A	anon	Pfam-B_1854 (release 5.4)	Family	Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [1]. This region called CR1 (conserved region 1) [1] is found three times in Adenovirus type 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR1 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 80 amino acid region is unknown. This region is probably a divergent immunoglobulin domain (A. Bateman pers. observation).	20.00	20.00	20.20	20.30	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.17	0.72	-4.48	20	217	2012-10-03 02:52:13	2003-04-07 12:59:11	10	5	50	0	0	184	0	58.70	42	36.33	CHANGED	oVshGsNhTLlGP.ssspVoWY.....ssshpchCptsphc......hpaoCstQNLTLlNVopsasG	.....VshGsNhTLlG...P...sss...VT.Wa......ssphp.chCstsphc..........hpaoC..N.tQN..LTLlNVspsapG...	0	0	0	0
+1108	PF02439	Adeno_E3_CR2		Adenovirus E3 region protein CR2	Bateman A	anon	Pfam-B_1854 (release 5.4)	Family	Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [1]. This region called CR2 (conserved region 1) [1] is found in Adenovirus type 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR2 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 50 amino acid region is unknown.	26.20	26.20	26.20	26.70	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.01	0.72	-4.41	9	114	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	48	0	1	96	0	37.90	49	13.63	CHANGED	IPsShIuIIsAVllGhslIIlChhhYACCY+Kh+.p.Kh	.IPsoTlAIlsuVlsGhhllIIshhhYhCChK+.+.a.+....	0	1	1	1
+1109	PF03376	Adeno_E3B		Adenovirus E3B protein	Mifsud W	anon	Pfam-B_3736 (release 6.6)	Family	\N	25.00	25.00	27.60	27.60	20.60	18.50	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.33	0.72	-4.06	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	67	0	0	48	0	66.40	59	73.42	CHANGED	VuclsPDCLsPFssYLlFsFVTClslCSIlCllIsFhQhlDalaVRIAYhRHHPpYRNppVAsLLpL	...VuHAoPDCLGPFsoYLLFAhlTChCVCSIVClVITFhQhlDWhhVRhsYL+HpPcYRspsVAtLLRL.......	0	0	0	0
+1110	PF04528	Adeno_E4_34		Adenovirus early E4 34 kDa protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4904 (release 7.5)	Family	Conserved region found in the Adenovirus E4 34 kDa protein.	25.00	25.00	49.30	48.70	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.97	0.71	-4.61	17	117	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	86	0	0	105	1	147.40	57	51.52	CHANGED	Ltshh+phlhGshhNpcahWYRchVNpthPcElhYVGSVahRGtHLIYl+l.....haDuchhsllcphs...aGhshhshGlhsshlVLsCppCs.shoEhphRsCA+RTRplhh+slpllsppsh...............ppStsEccRQ+hL+tLhpap+slhh	..........................LAsWFR+lIhGsMhNQRhPWYRplVNh.pMPKEIMYhGSVFhRGRHLIYl+I.....WYDGHsGuIlssMS.....FGWSshN...YGLLNNhVIhCCTYCp.sLSEIRMRCCA+RTR+LML+AltIlsc-TssscP..........lsSSRTE.RRQRLLRuLMc+pRPI..h................................	0	0	0	0
+1111	PF00541	Adeno_knob	adeno_fiber; 	Adenoviral fibre protein (knob domain)	Bateman A	anon	SCOP	Domain	Specific  attachment of adenovirus is achieved through interactions  between host-cell receptors and the adenovirus fibre protein and is  mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.	25.00	25.00	65.80	65.70	17.40	16.80	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.40	0.71	-4.61	46	374	2012-10-01 20:11:45	2003-04-07 12:59:11	12	13	129	144	0	334	1	176.00	40	50.73	CHANGED	LWTTPDP.SPNCpl...pp-pDuKLTLsLTK.CGSQlLuoVSLlsV.pGp.hpslssshp......shslpLhFDssGsLhs........sSslspsYWNa.................................RsssSss..ussapNAls...........................FMPNhsAYP+...........sppspu+spIhuplYLpGp...shpPlslploaNppsss.......sYSloFsashsps..Yt...s..sFsooShTFSY	....LWTTPDP.SPNCpI......ppspDuKLTLlLTK.sGuplhusVSLlsV..sGphphlsssps.....hshslcLhFDssGsLLs........sssh..KshWsa.................................Rss..sohs..ssshpsAlu...........................FMPshsAY.Pp...........spppps.cshlhussYhtup...stpPlslplshNpcsss.......sYSIoFsauhsps..ht.....s.hsF.sTosaTFSY...	0	0	0	0
+1112	PF00608	Adeno_shaft	adeno_fiber2; 	Adenoviral fibre protein (repeat/shaft region)	Bateman A	anon	Bateman A	Repeat	There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.	20.50	20.50	20.60	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.35	0.73	-7.21	0.73	-4.10	63	1159	2009-01-15 18:05:59	2003-04-07 12:59:11	12	20	137	15	1	857	6	30.00	30	24.56	CHANGED	sssLslshussLslss.ssLslplussLshs	...sssLoLshusPLslss.ssLsLpluusLsl...............	0	0	0	0
+1113	PF04881	Adeno_GP19K		Adenovirus GP19K	Kerrison ND	anon	Pfam-B_6142 (release 7.6)	Family	This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER).  The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes [1].	20.00	20.00	22.00	83.50	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.00	0.71	-4.43	6	78	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	49	0	0	58	1	133.40	56	81.67	CHANGED	CsLTFAs-ssc.CsVLIKCua-Ccsl.cIpapNKThspol.sssWpPGs.sp.YTVoV.............pGsDGo.hhsNsT....FIF.spMC..........DlsMaMS+QYsLWPP.oKENIVsFSlAaslsACllouLlslslthhlph+PRpuN.EKEKhP	...CslThus-pSc.CsVlIKCta-C.h..pITaKNKThsNsh.susWcPGD..p.YTVoV.............+GsDG.....NpT....FIF.phMC..........Dlshahu+.auLWPP.oK-NhVsFSlAaslhAClhouLLssslhhhlpp+PR.uN.EKEKh..........	2	0	0	0
+1114	PF01065	Adeno_hexon		Hexon, adenovirus major coat protein, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_885 (release 3.0)	Domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX.  The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	18.60	18.60	20.00	20.00	17.90	17.80	hmmbuild  -o /dev/null HMM SEED	495	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-12.75	0.70	-5.64	36	2918	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	287	43	0	1583	0	236.80	39	78.17	CHANGED	FRNPTVAPTH-VTT-R.SQRLQLRFVPVppEDspYoY.KsRFoLuVGDNRVLDMuSTYFDIRGsLDRGPSFKPYSGTAYNsLAPKuAsNNs.ap.................ssss.................spshAQAshhs...................sspsst.ttspthhsssshpPpPQlG..tss...Ws...tspsstptuuGRlL.....csssshhP......CYGSYApPTN.pGuQu................s.slpphaassssssss.........ssslhhsEsVs..LpsPDTHlVhh..ssss..sups.hs..uhPNRPNYIGFRDNFIGLMYYNSsGNhGVLAGQuSQLNuVVD.LQDRNTELSYQhhLssLsDRsRYFShWNQAVDSYDs-VRlI-NcGhED-hPsYsFPlsGlss..tsasslptsss.....tsapsssssssss.....hluhGNlsuMEINLsANLaRsFLYSNVAhYLPDchKaT...PsNls........LP.sNsNTYsYMNuRlPsssllDoalNIGARWSlDsMDNVNPFNHHRNsGL+YRSQLLGNGRYspFHIQVPQKFFAIKNLLLLPG	.................................................................................................................................................................................................u.hs.........................................................t..t.h.t.....Ppsp.G.....tt.....................huRhh.....c..t............................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1115	PF03678	Adeno_hexon_C		Hexon, adenovirus major coat protein, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_885 (release 3.0)	Domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX.  The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	21.40	21.40	21.60	22.10	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.60	0.70	-4.90	23	736	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	213	43	0	552	0	193.00	81	34.68	CHANGED	NsTNDQoFsDYLuAsNhLYsIPAssTslsIsIPuRsWuAFRGWSFTRlKspETPslGusaDP.FpYSGoIPYLDGTFYLoHTF++VSIpFDSSVsWPGNDRLLoPN.FEIKRs..lD...uEGYshuQSNhTKDWFLVQMhANYNhGYQGY+lPssh+.hpYuFl+NFpPMoRQlPshsp.st.achlshs.p...............aNNSGahuhps....shtt+pGHsYPANWPYPLIGpsAlts..lTp	........NDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWSFTRLKTKETPSLGSGFDPYFsYSGSIPYLDGTFYLNHTFKKVSIMF.DSSVSWPGNDRLL..TPNEFEIKRo..VD...GEGYNVAQCNMTKDWFLVQMLupYNI..GYQGFal..PEuYKDRMYSFFRNFQPMSRQVVDphpYpc.YptVslsaQ...............HNNSGahu.hu......s.ppGpsYPANaPYPLIGtpAl.s.....hp.......	0	0	0	0
+1116	PF02456	Adeno_IVa2		Adenovirus IVa2 protein	Bateman A	anon	Pfam-B_1982 (release 5.4)	Family	IVa2 protein can interact with the adenoviral packaging signal and that this interaction involves DNA sequences that have previously been demonstrated to be required for packaging [1]. During the course of lytic infection, the adenovirus major late promoter (MLP) is induced to high levels after replication of viral DNA has started. IVa2 is a transcriptional activator of the major late promoter [2]. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.18	0.70	-5.81	11	128	2012-10-05 12:31:08	2003-04-07 12:59:11	10	1	98	0	0	181	10	359.20	69	84.98	CHANGED	lDpp.ht.lp-hac+ltshppslpshshu.h.....tPh....ppFsSa-chhuhuG..llpcLpcsppplccthstsphaLpssGphsSLNhshQPlIull....YGPTGsGKSQLLRNLlSspLIsPsPETVhFIsPphsMIPPpEhsAWchQlsEGNYssss-GTlsPpouTh+PcFlcMoY--hTss-NhDlscPpNlFspAAppGPlAIIMDECM-cLssp+uIShhFHAhPSKLasRaspCTGaoVFVVLHNMNPRpshuGNIssLKIQAKlHIlSs+hpP.QlsRFlpoYo+uhspsl.slLLKsIFsahpppspYsWllYNssP.pEuhpWs.hLcsppulhPhhLNlQshlacslc+Ip+hh....p-RpRappth+pKhp	..........................................LDRDAlE+lTELWDRLpLLpQTLscMPMADGL....KPL.KNFuSLpELLSLGG-....RLLs-LVRENhpVRcMhNEVAPLLR-.DGS.C..SL...N...Yp.L.Q.P.V.IGVI....YGPTGCGKSQLLRNLLS.uQLIoPAPETVFFIAPQVDMIPPSEhKAWEMQI..CEGNYAPGPEGTllPQSGTLRP+FlKMuYDDLTpEHNYDVSDPRNVFApAAA+GPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDLGGNIANLKIQAKhHIISPRMHPSQLNRFlNTYTKGLPlAI.SLLLKDIhpHHAQ+PCYDWIIYNTTPEHEAhQWs.YLHPRDGLMPMYLNIQoHLYRVLEKIHRsL....NDR-RWoRAYRARps.........................................................................................	0	0	0	0
+1117	PF01686	Adeno_Penton_B		Adenovirus penton base protein	Bashton M, Bateman A	anon	Pfam-B_1180 (release 4.1)	Family	This family consists of various adenovirus penton base proteins, from both the Mastadenoviradae having mammalian hosts and the Aviadenoviradae having avian hosts. The penton base is a major structural protein forming part of the penton which consists of a base and a fibre, the pentons hold a morphologically prominent position at the vertex capsomer in the adenovirus particle [1]. In mammalian adenovirus there is only one tail on each base where as in avian adenovirus there are two [1].	25.00	25.00	94.70	94.50	15.40	15.00	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.49	0.70	-6.25	19	217	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	130	39	0	205	0	436.00	67	95.37	CHANGED	h-..hsPPRhhAPTEGRNSI+YopLsPL.DTTKlYhlDNKouDIsoLNaQNDHSNFhToVlQNsDhoPtEASTQoIpLD-RSRWGG-LKTlL+TNhPNVscFh.SNoh+s+lMss................ctssssspYEWh-lolPEGNao.stlIDLhNNAIl-pYLtlGRQpGVhcSDIGVKFDTRNFpLGhDPlTsLVhPGhYT.cAFHPDIVLLPGCuVDFTaSRLsNlLGIRKRpPYpcGFhIhYEDLpGGNIPALLDlpsYpts....................................................................................IpP.lhpDSpuRSYpVhpssos.....TtYRSWhLAY.N........spsuspspTLLTsPDlTsGltQlYWSLPDhhpsPlTF+ss.ppssshPVVGhcLhPlhu+shYNspAVYoQllcptTs.tTpVFNRFPENpILhpPPhsTlTslSENVPuloDHGTLPL+NSlsGVQRVTlTDsRRRsCPYVYKSLusVsP+VLSSpTh	............h.-s.hVPPRYhuPT-GRNSIRYS-LsP.aDTT+lYLVDNKSuDIsoLNYQNDHSNFLTTVlQNNDFTPsEASTQTINFDERSRWGGDLKTILHTNMPNVNEaMFTsKFKARVMVuR+.s..........tsDtupchLcY-WaEFTLPEGNFSETMTIDLMNNAIl-NYLpVGRQNGVLESDIGVKFDoRNF+LGWDPVTKLVMPGVYTYEAFHPDlVLLPGCGVDFTcSRLSNLLGIRK+QPFQEGF+IMYEDLEGGNIPALLDVcpY.cScpchtptttts...t.......................................................t.httt..tsstcclsIpP.lpcDspsRSYNVlpssp.......sThYRSWYLuYsYG..................DPEKGVpSWTLLTTPDVTCGuEQVYWSLPDhhpsPVTF+so.ppsssaPVVGsELhPh.huKSFYNt.AVYSQhlcp.Ts.hT+VFNRFP-NpILhRPPssTlToVSENVPAloDHGTLPL+sSltGVQ...RVTlTDsRRRTCPYVYKuLuhVsP+VLSS+Th.	0	0	0	0
+1118	PF03955	Adeno_PIX		Adenovirus hexon-associated protein (IX)	Finn RD	anon	DOMO:DM01967;	Family	Hexon (PF01065) is the major coat protein from  adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together  by 12 copies of polypeptide IX.	21.80	21.80	23.30	42.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.58	0.72	-3.53	12	121	2009-09-10 22:51:00	2003-04-07 12:59:11	9	1	96	4	0	85	0	109.30	59	79.56	CHANGED	-GtlhosaLTsRLPsWAGVRQNVhGSslsGtPV.hPuNStshphtphs..ushcssAAAsu..ptutssspshstsht.hstlt.ph.u........pctLthllspLcpLpppLtth	.EGGlFSPYLToRLPuWAGVRQNVMGSTVDGRPV.hPANSST.hTYATVG.uSoLDosAAAAA..uAAA.TAptlAushh..us.ussssSS.....ltE-KLhsLLAcLEALoppLus.L.....................	0	0	0	0
+1119	PF03910	Adeno_PV		Adenovirus minor core protein PV	Finn RD	anon	DOMO:DM04810;	Family	\N	20.30	20.30	30.70	24.40	17.50	16.80	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.56	0.70	-5.37	12	112	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	88	0	0	111	0	325.30	60	96.48	CHANGED	MSKRKhKEEhLpslAPEIYGP..s.hpsch..KPRplK+V........KKcc+..tc-..........p......-stVEFVRpFAPRRRVQW+GR+VpRVLRPGTsVVFTPGERSshp..KRsYDEVYuD-DILEQAApphGEFAYGKRuR..............-.lulsLDpuNPTPSLKPVThQQVLPs.s......+RGlKRp.ttcl.PThQlhVPKRp+lE-VL-phKs............................................................-PslpPEVKV..RPIKpVAPGLGVQTVDIpIPs............-s............M-sp....sc.P.s.s.................................hsshpl....QTDPWh.hs..........ssppp+ppR+YGsAstlhPpYsLHPSIh........PT.............PGYRGpp.apsphptssRRRpssspRp+p........hsPstlhRshsRRG+..pls	.......................................MSKRKhKEEMLQVlAPEIYGP...s..ts-p...KPRKlKRV................KK+c..c...tt................s........-stVEFVRpFAPRRRVQWKGR+VpRVLRPGTsVVFTPGERSusp..KRsYDEVYGD-DIL-QAA-RhGEFAYGKRuR.............p-hlulPLDcuNPTPSLKPVTLQQVLPsss....pRGlKRE..upslhPTMQlMVPKRpRlEDVL.-p.hKh.......................................................D.tlpPE.VKV..RPIKQVAPGLGVQTVDIQIPs...................s.....................M-sppc.P...................................................................ooohEV....QTDPWhsssss............sssp.pRRR+.aGsA.StL....hPsYsLHPSIl...............PT.............PGYRGop.Yt...sRp.psup+RRppsspRRR.........lsPu.tVpRVshRcGR..hlh................	0	0	0	0
+1120	PF01310	Adeno_PVIII		Adenovirus hexon associated protein, protein VIII	Finn RD, Bateman A	anon	Pfam-B_1405 (release 3.0)	Family	See Pfam:PF01065. This family represents Hexon.	25.00	25.00	49.30	40.90	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.58	0.70	-4.53	17	163	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	109	4	0	124	0	206.60	56	98.48	CHANGED	cphPTPYlWpYQPptGhsAGAuQDYoo+hNWl........sAGPpMhs+lpslpspRNpllhppAthspsPhss.N.ssWPAs.lhp.sss...Ppslhhs+spsh-pth.........TsuGhQLAGGut................................hthpG.hQLss........P.sttth..RPsthh..QLuGuuh......hs..ppshhhhppusS..lPRoGGluspQFlcEFsPsVY.pPF.SGsPssaPcpF.s.Ycssssshcuas	.............................................K-IPTPYMWSYQPQhGlAAGAuQDYSo+MNWL........SAGPpM..ISRVNslRsp.RNpILLcQAAlTsTPRspLNP.sWPusLVYQEhPs...PTTVlLPRDAtAEVpM..........TNuGsQLAGGuphs.hts.......................................ttuIKpLhIRGRG.hQLNDEh.............VSSuhGL..RPDGlF..QLuGuGR....SSFTP.pQAhLTLpoSSS..pPRSGGIGTlQFVEEFlPSV.YFNPF.SGSPGpYPDpFIPNFDAls-uVDGYD.....................	0	0	0	0
+1121	PF02459	Adeno_terminal		Adenoviral DNA terminal protein	Bateman A	anon	Pfam-B_1602 (release 5.4)	Family	This protein is covalently attached to the terminii of replicating DNA in vivo [1].	20.60	20.60	21.20	243.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	548	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-12.75	0.70	-6.34	17	138	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	99	0	0	157	3	552.20	65	87.77	CHANGED	MLhsLuPpsPsTtphPhhthPPPHLLlGYQYlhRshNDYlFDsRsYSpLpYpphhp.t...pplsWoshssCSYoINTGuYpRFl.Dh-....NFp-TlsplQpAlLh-RllADLulht...hRGhGhs.h......tttpls.......ptl.pcphpplsthpspuhGhupchRlp..........pAup+DhslLssIR+L+sAhhpFLlspth..........tstcshLsLP.....s-s.sWLsuFlccFuc....php............tphsspphh+sllosLoLsps..........tusshsGGsFp...........LRPRE.sGRAVTEo.MRRpRGchlcRFlDRLPlppRRRRh..ssP.P..s.ptt.tttth....-Ep.p.............tFt-EVhsolsEsIchLp-ELTssARpppFFsFAscFYcll.chcsh..uclsEthLRRWlhYFFlsEHIAoTL.YLappLphpt.FtRaVplphsQVlhRuRDtsGp.laoRVWsEpupsA..FppLhpRIhpDlhshlERAGct-..hpp-Eh-pFhs-Isap-sSGDlpEIL+QlslN-s-IDSl-lSFRhKhoG.VsaSspcpIps.sRRVlptA..LRppc.ps	..................MLEDLAPGAPATpRWPLYRpPPPHFLVGYQYLVRTCNDYlFDoRAYSRL+YoEllpPG..hQTVNWSlMANCoYTINTGAYHRFV..DhD....DFQsTLTQlQQAILAERVVADLALlQP..hRGaGlTRM......tt-ppls.........................lERLMpDYYKsLuRCQspAWGMA-RLRIQ..........QAGPKDlVLLATIRRLKsAYFNaIlSshsu......................ppst.tpTsLSLP...............CDC.DWLDAFlERFSDP..VDLpsl.........................htssPTtQLI+CIVSALSLPNG.s................s...phpchpGGVFp...........LRPRE.sGRAVTET.MRRRRGEhIERFlDRLPVRRRRRRs...PPP....Ps......sP.E..pt...........t.E..............hh.......E.......EEEEEt......................................ssFEREVRsTlAELIRLLE-ELTVSAR..NuQFFNFAVDFYEAMERLEAl..GDloEhsLRRWIMYFFVsEHIATTLNYLFQRLRNYAVFsRHVELNLAQVVMRARDs-GsVVYSRVWNEsGhsA..FSQLMuRISNDLAATVERAGRGD..LQEEEIEQFMuEIAYQDNSGDVQEILRQAAVNDsEIDSVELSFRFKlTGPVsFTQRRQIQDlNRRVVAHAStLRAQ+p.........	0	0	0	0
+1122	PF03228	Adeno_VII		Adenoviral core protein VII	Bateman A	anon	Pfam-B_3049 (release 6.5)	Family	The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.	21.20	21.20	23.80	23.80	20.80	18.30	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.78	0.71	-3.51	14	129	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	102	0	0	107	0	116.10	57	66.84	CHANGED	MuILISPSNNTGWG.LGs.ppMaGGA++hScpHPV+VRsHaRAsWGuhp....GRssh..h..th....t.hp...ssthssTsDsVhcs...lsAsuRtht+p+RRhc....h.sRR+thttsotAhRt........ARu	..MSILISPSNNTGWG..Lss.....Sp.....MY.....GGA++RSsQHPVRVRGHaRAP..WGAhKtt..........ttsRTT..VDDVIDpV..VADARNYT...s..ssSTVDuVIDS...VVADARsYARRKpRpR....RhARR+ps...TsAMRAAR.Alh...................................................................	0	0	0	0
+1123	PF04439	Adenyl_transf		Streptomycin adenylyltransferase	Kerrison ND	anon	DOMO:DM04121;	Family	Also known as Aminoglycoside 6- adenylyltransferase (EC:2.7.7.-), this protein confers resistance to aminoglycoside antibiotics.	20.60	20.60	20.60	20.90	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.90	0.70	-5.40	6	625	2012-10-02 22:47:23	2003-04-07 12:59:11	7	5	514	1	75	442	9	256.10	36	96.18	CHANGED	MRoEpEMhDllLchA.pcEclRlVsLpGSRTNpNlsKDcFQDYDIsYhVoDl-sFIp-csWLppFGchIhhQcPEDh-h...Fss-hsptauYlMLF-DGNKlDLTLhshc-hpcah.......-sDsLhKlLlDKDshl.p.lsPsDppYalK+Pop+EFpcCCNEFWhVosYVsKGlsRcEIlaAhDHhppIlRsE.LL+MluWaIu.p+GaplShGKNhKahc+YLsschWpch.uTashsuYcchWpSLFhsppLF+phupcVupthsYsYP.-h-.csIpcYhcshhpp	......................................MRoEpEhhplllphA.p-c+IRsVhhpGSRsNs.......ps.+DpFQDY..DIsYhV..p..-..hp...s.a...hpst........s........WlppF.Gp.h.lhhQpPcc.hph.......hs...s..p....p...p...t..hsYL..MhF.p.D.G.s+IDLTLhPlcplcpah..................................pt......Ds.....LhplLlDKDshh.....t....s.s..o..-.psY.hl.pp...P..op.p-Fp.csCNEF.WasosYVsKGLhRcElhaAhshhpths+pp.Ll+hls.Wpl.uh.cpsa.p.l.s.lGKphKalppY.l.st-h..hcphhpoashssh-phWpuLhhhtpLF+phupclA.pp..htapYs.phs.cpltpYhpph...h.........................................................	2	29	51	60
+1124	PF01928	CYTH	Adenylate_cyc_2; 	CYTH domain	Aravind L	anon	Aravind L	Domain	These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate.  Six distinct non-homologous classes of AC have been identified.  The structure of three classes of adenylyl cyclases have been solved [3].	23.10	23.10	23.10	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.36	0.71	-4.61	51	3690	2012-10-01 23:11:28	2003-04-07 12:59:11	16	10	3229	34	930	2667	248	182.60	21	64.24	CHANGED	hhElEhKhhl....t..t......htphpspthshhpppshYasss.....shphttpp.tsLRlR............................sptth.lThKsst..t......phpsths..........................h.t..hhtlhsths.....................hp.h..sslpppRptapl....tt........stlslDtschl............hs.hElEhpspstpph.phhcp...........t..t.hth.thsthtRsYhphhtt	...............................................hEIEhKhhls.........tthpt.l...............htph.....t.....h.p....t.t...s.....h.....p......t.sh....Y.a.-Ts........c....L...t.t.p...c...huL...RlR...........................h.....s..st....th...hTlKs..ss.......................hsshhp..t....Eh.ph.ls...................................................hst..hht.h.htths.........................lp.s..l...hs..hshh.R....pphhl...............st...................hplslD....p....schh..........................sh.s...-hEL..El....p..s...s..s....h....p...t....h..h..p.hhpp..........h.......t....h......ts.....schtRhh..h...st.....................................................................	0	244	546	742
+1125	PF01295	Adenylate_cycl	Adenylate_cycla; 	Adenylate cyclase, class-I	Finn RD, Bateman A	anon	Prosite	Family	\N	21.80	21.80	25.30	25.30	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	605	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.99	0.70	-6.25	18	1028	2009-10-20 15:17:26	2003-04-07 12:59:11	13	6	915	0	113	599	28	520.90	64	68.95	CHANGED	-WlDhGGhuplsApEYFGASLWQLYKGIDoPYKuVLKhLLLEAYStEYPNTcLluhphKp+hh........sschs.paphDsYhhMLE+VTpYLpplsDhpRLDhlRRCFYLKssEslu...p..tsssWRpphLscLlspWsWocpplppLDpRpsWKIcpVcps+spLl-tLMtSYRNLIpFAR+pplssSIsPpDIuILoRKLYuAFEsLPGKVsLlNPpIS.sLSEssLTFIpVpp.s+t...psGWYLhNQuPcstthsspphlEasc.LsKLVAWuYFNGLlTspTpLHlhspsscl..spLppFlsDL+toFPlp.sspsospsLppPCEIRpLslhlNLppDPTp+h..pslchchpsoDlFSFGpppcsLVGSIDllYRNsWNElRTLHFcGspAlLcALKsl.sKhHpsussPcSlcVFCYSp+hRuplcshVtsLlpcCIplpLus..ppptpphpsL+luGcsatlFFEc+GlSlQcLpsshsh..............aspIoppKht..sh...ttppppphPt.IDuFASEGhlQFFFEssc..puFNVYILDEsNclElYppCsGsK--hl+clN+hYsssp.cptpsstphl..NFNhPQFYpllps......sstlpllPFpuptptp	........................................EWLDLGGLSoLSAEEYFGASLWQLYKSIDSPYKAVLKT.LLLEAY........SW....E.YPNs.+LLAcDlKQRLa........sGEls...saGLDPYshMLERVTcYLstIp..D....TRL.DLVRRCFYLKVsEKLS....p.p.p.u.ssuWRRtlL.spLVpEWsWsc.sp.LshLDNRusW.KI-QV+csHscLLDAhMQSYRNLI+.FA...R.RN..slos.S.hSP...QDIGlLoRKLYA.AFEsLPGKVTLlNPQISPDLSEssLTF..I..VPs...G..Rs.....N+sG...WYLY..N..puP...........shc..sI..l.u.a..pPLEYNRYLsKLVAWAaFNGLLT.upT+Lal+ussh.s...sKLpchVuDl.pppF.P.LR....ls.sPT..sc...A.....LhoPCEI.RcLAllVNLEhDP.Tutapsp.sl+hDh+clDlFS.FGppQpCLVGSlDLlYRNSWNEVRTLHF.sGEpuhl-ALK.TlL.....G.KMHQDA...s...P.P..-.SV-VFCYSp+LRGlIRsRVpQLVuECI-LRLus..pppcssRFKALRVuGQsWGLFF.ERhs.VSVQKLENul-F.........Ysu.ISp.NKL+.Ghslpl....cssps+.....L.P..sVVDuFA.SE.......GlIQFFFE....-o....t..p.p.GFNIYILDEuNRlEVYHcC-GoK-ELV+-VsRFYoSu+..Dc.s.hu..ushI....NFN.LP.QFYQIVps......-G..ctpVlPFRsp...p.h..........................................................................................................................	0	16	40	81
+1126	PF00709	Adenylsucc_synt		Adenylosuccinate synthetase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_690 (release 2.1)	Domain	\N	19.90	19.90	21.30	20.20	19.00	19.70	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.50	0.70	-5.82	92	5395	2012-10-05 12:31:08	2003-04-07 12:59:11	16	13	4698	55	1514	3933	4438	387.40	46	96.96	CHANGED	sslllGsQWGDEGKGKlVDhLu.......pcsDhVVRapGGsNAGHTlVss....s.c+atLHLlP..SGllpsss.hslIG.NGVVlcP.sLlc.Elcp.Lp.ppG.lsh..scLhISccAHllhPaHptlDthpE....t..pupt....pIGTTt+GIGPsYpDKsuRp.G.lRlsDL..h.c......chhpc+Lcph..........lp.p.Nthh.ppha.........t....p.h.shcplhpchhphsc............................................plp....sh..ls.Dsshhlpculcp.sKplLaEGAQGshL.DlDaGTYPaVTSSsssuuGsssGsGluPppls..pVlGVsKAY.oTRVGsGPFPTE..lh........s-......hG-plp.............ct..............................................G...p....EaGsTTGRsRRsGWhDhVhl+Yus.plNG.hsslslTKLDVL....sshcclKlCsuYch....sGc....................hlc.thPss.httlpcscPlYEphsGW.p....pchssscp..a--LPtsAppYlctlEchl.uls...............lshlSsGPc.RcphIh	....................................................................................................................................................................................s.lVVlGsQW.GDEGKGKIsDh..Ls................ppuchVsRa.Q...GGpNA..GHT..lVl................s............G..pcahLHL.lP..S.GIh.pts......h....hslIG........NGV..VlsPtsLhc..Elpt...Lc..p..p.......G.......lss..........ppLhI...ScpA...p...............l...IhPYHhtlDphpE................pt..+Gsp.........pIGTTt+GI.......GPu.Y.....t.....DKs.....u.............Rh...G.....lRluDL................h..-t.....-thtc+Lcps...............lph+..Nhhh...pha.......................................tt.......psl...sh.cclh..c...c.hh..t...hu.c............................................tlp.....sh...ls..DsshhLs.......p.Ah..........c.p....G...c.plLFEGAQG.............shL..DID.a.........GT.Y.P....aVTSSNssAG.Gs...ss.G.u.G.lGPptls....pVlGlsKAY.oTRV......G.........s......G..PF..PTE..Lh...DE...........................hG-.tlp..............ch..............................................................G....p....E.........a.Gs.TTGR.R..RsGWhD...sVslRhuh.p.......l......sG.l......os..lsLTKLDVL........s..Gl.c...plKlCluYch........-Gc.......................pls...hP..hs...hpth..ppscPlYEphP.GW...p....Eshtus+s.....hc-.........LP.psAppYlc..................RlEEls.Gl............................lshlSsGPcRppTh...........................................................	0	480	920	1248
+1127	PF00106	adh_short		short chain dehydrogenase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family contains a wide variety of dehydrogenases.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.81	0.71	-4.33	230	80936	2012-10-10 17:06:42	2003-04-07 12:59:11	20	600	6093	916	30667	110825	42278	163.30	25	56.70	CHANGED	GTlLlTGGoGuLGttlARaLspp.Gsc+LlLsSRp.............u.tusuuscL.....hs-Lp...thG..ApVplsu.sD...luDc.sslssllssls...t.tPlsuVlHsAGl...lc..Duslssh.....os-chs..pVhpsK....ssuAhpLcclstc....hs......LstFVlaSSsAulhGusGQusYAAANuaLDuLAcpR+upGL	...................................................................................ssll...T...G......u.........u.....p.........G.....I......G....t........u.......h.............A...........p.....t.......h....u........p........p.....u............u......................h.........l.........l....h...s....s.ps..............................................pt..h.pph....................hp.p.lp.............t....G......s........p.........s.........h..........s................h..........t......h..........D.................l....s......s........t.......p...........s.......l.........p..............p.........h.......h........p......p............h...........h...........t............p..........h..........G..........p............l.................D.............l.....L..........l...........N.....N.......A.........G....l.....................tt...............s........s.......h......t......c.h..........................s....c....p.......a....c............p...h.....h..........s..l..N.................l.h...u....s....h....h....h..s....p....t.hhshh.................................htps........tG.p..I..l..s..l........u...........S............h............s............u............h............h.............s..............................s............t..............................s............s............Y..........s.......A....o..K....tu....l..h.u.hscslsh-..t......................................................................................................	2	8711	17860	25336
+1128	PF04619	Adhesin_Dr		Dr-family adhesin	Kerrison ND	anon	DOMO:DM04566;	Family	This family of adhesins bind to the Dr blood group antigen component of decay-accelerating factor.  This mediates adherence of uropathogenic Escherichia coli to the urinary tract.  This family contains both fimbriated and afimbriated adherence structures [1].  This protein also confers the phenotype of mannose-resistant hemagglutination, which can be inhibited by chloramphenicol.  The N terminal portion of the protein is though to be responsible for chloramphenicol sensitivity [2].	20.60	20.60	20.70	22.00	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.76	0.71	-4.46	6	61	2012-10-02 17:35:21	2003-04-07 12:59:11	7	2	5	49	0	67	0	136.70	49	86.71	CHANGED	uFTsSGoTGTscLTVTEECpVpVsspssoKpRu-LsDuAhlGslolsApGCsTcp.sAL+AsusNYcssp.hhLhp-stps+lsV....sltAsDGs.sWTsDsushYRsssGsWsGolhllVcGDQsspPsGsYTLNL-GGYWsp	..............FTsSGoTGTscLTVTEECpVpVssho..soKsRupLs.-ustIGslsVpApGCsscQ.lAL+AssDNa-psp.hahhp-NspDKLhV....slpusDGS.uWTsDsGVaY+s........csGsWGGplsl.hVcGDQTspPsGsYTLsLsGGYWsc.....	0	0	0	0
+1129	PF03257	Adhesin_P1		Mycoplasma adhesin P1	Mifsud W	anon	Pfam-B_4117 (release 6.5)	Family	This family corresponds to a short 100 residue region found in adhesins from Mycoplasmas.	25.00	25.00	42.90	42.90	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.06	0.72	-3.67	7	75	2009-09-11 06:42:52	2003-04-07 12:59:11	8	2	7	0	10	73	0	87.40	58	10.15	CHANGED	pGSspptGS.oGo..SAGNPDSLcpDKlspSGpshTs.p......ouspssTNYTNLPP.s..........lTPTuDWPNALSFTNKN..NAQRsQLFLRGLLGS...IPVLVN+	..................................ptttS...uo..SAGNPsSLcpDKlop..SGps.os.p.....shsppcsTsYTNLPs.s...........loPTuDWsNALoFTNKN..NsQRsQLhLRGLLGo...IPVLlNK...........	0	9	9	9
+1130	PF00406	ADK	adenylatekinase; 	Adenylate kinase	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null --hand HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.92	0.71	-4.33	23	9734	2012-10-05 12:31:08	2003-04-07 12:59:11	17	83	7181	94	2694	6272	2767	160.60	42	74.26	CHANGED	llGsPGuGKGTQuppIsccaulsHlSTGDhLRApl.puGTplGcpAKphMDpGcLVPDElslsll+-cltps..ssppGFLLDGFPRTlsQA-uL-c....tshplDhVlpl-Vs--lllcRlouRhlp.ssGpsYah.apPP.c..hhsDhsup.LhpRuDDstEol++RLpsYpppTpPlI-aYppcGh	..............................................hhG.PGuGKGTp.........sth.lh...p....p....h..........t..h......s..p..l..S................sG....DhL.....R....u.........s....l......c....s..............s..........T......-.......L..........G............p..............p..................A...........K............sh...h..D......t...................G..p......L..V.......s....D.E.....l...l...........l...u...l.......l.+....-.R.....l...........s...................p...............s...........D..............s................p........p..........G.........F.......L.L.D.....G.F...PR.......T...ls.......QA.........-...u...........L.............c............c........................................................h..........u..............h.........s..............l..............D..........h..........V....l....ph..-.V.s.-..-.lll.c....R..hsGRthp.ssGtsYH.hapss....................................................................h.tshsDhsuttLh.RsDD.p.pE..T..l.+.p...Rlt..a...h.....p.........s...t...PlltaYtt...h............................................................................................................................................................................	1	926	1587	2197
+1131	PF05191	ADK_lid		Adenylate kinase, active site lid	Finn RD	anon	Manual 	Domain	Comparisons of adenylate kinases have revealed  a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly  structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely  structural function [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.93	0.72	-4.29	141	6209	2009-01-15 18:05:59	2003-04-07 12:59:11	9	17	5432	61	1176	2972	552	36.00	57	18.92	CHANGED	RRlCts..CGpsYH........lhasP..PKhpGlCDhCGs..pLhpR.sD	....................RRsHhs..SGR.oYH........shaNP.........PK..........hEG.........K............D.Dl.TGE...-Ll.RcD..............	0	385	706	964
+1132	PF05221	AdoHcyase		S-adenosyl-L-homocysteine hydrolase	Finn RD	anon	Pfam-B_157 (release 2.1)	Domain	\N	25.00	25.00	25.20	27.90	24.40	24.20	hmmbuild  -o /dev/null --hand HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.67	0.70	-5.45	9	2525	2012-10-02 14:31:05	2003-04-07 12:59:11	12	10	2027	95	1084	2299	4318	421.00	48	95.54	CHANGED	tcYKVtDIuLAsFGRKEl-lAEsEMPGLMshRccYGsSQPLKGA+IuGCLHMTlQTAVLIETLsALGA-VRWuSCNIFSTQDaAAAAIA.........tuGlPVFAWKGET.EEYhWCl-pslp.asDG..tssNhILDDGGDhThLlpc.........................................KasphhtsIhGlSEETTTGVH+LYch.ppGpLhhPAINVNDSVTKSKFDNlYGCR-SLlDGl+RATDVMlAGKlAVVsGYGDVGKGCAuuL+GhGARVlVTElDPIsALQAuMEGapVsslE-lspcucl..hlsTsssssIlsscch.hhppsslssshtah-h-.psthhphsupcphsIKPQVDcahh.sGp+IILLAcGRLlNLGCATGHPSFVMSsSFTNQVLAQlELWspt..............ucY....cssVYlLPKpLDEcVAtLHLupLss+LTKLoccQAcYlGlPlpGPFKsDHYR	...........................................................................................................................capVtDl.u.LA..saGR+EIclAEpEMPGLM.u.lRccaus..pp.PL+GARIsG.s.LHMTlQTA...................VLIETLhALGA.-.V...R...WuSCNIa.STQDcA...AAA.l.A.............t.s.G.l.P.V..FAWK...GEo.-EYahshcpsl..a...........s.s...................ht.s.NhILDDGGDh.Thhl+..p.................................................ca..sch..hp.p...l............+G..loEETT......TGV.+.RLYphtcp....G...pL.hhPAI.NVNDSVTKSKFDNhYGCRcSLlDGIpRuTDlhlAGKhsVVsGYGDVGKGsAtuL+uhGApVhVTElDPIsALQAsM-GacVssh--ssppuD................................................................hhssssssphhhtphhthhptsshssssthtp.p..hthhthpshphhph+splcchhhssG+plIlLuEGRLlNLGsAoGHPSF.VMSsS.FsNQ...s..LAQI.ELapp.t.........................................s.pY......c...p.VY..h.LPKcL...DEcVApLHLpplGscLTpLop-QAcYlGlshpGPaKsphYR........................................................................................................................................................................................................................	0	369	670	896
+1133	PF00670	AdoHcyase_NAD	AdoHcyase; 	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	Bateman A, Griffiths-Jones SR, Finn RD	anon	Pfam-B_157 (release 2.1)	Domain	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.03	0.71	-4.40	16	2557	2012-10-10 17:06:42	2003-04-07 12:59:11	16	15	2063	95	1090	4107	3855	158.70	52	35.69	CHANGED	NLYGCRESLlDGI+RATDVMIuGKlAVVsGYGDVGKGCAtuL+uhGARVlVTElDPIsALQAuMEGapVsTlE-ssccucIFVTTTGN+DIIps-HhppMKcsAIVCNIGHFDsEIDVshLpss.uhcp.slKPQVD+aphss.G++IILLAEGRLlNLGCATG	..............................NhYGCRcSLl..DGI...p....R..u..T.D.l...h...lAG...K.....s.....sV.Vs.G.Y.G.D.............VGKGsAt.uL+.uhG.A...p...V.h.....V..T.....E...l..D.......P....I...s........A......L....Q....A.........s...M....-......G.......a....c.....V.....s.............s.............h.......-............-.........s............s...p...............p........u.....D...I.....a.....V....T....s.....T....G....N....p...c....lI...st.-.Hh.c.t..MKc.pA..IV..s.N.....I...G..H...FD..sEI.D.....l..s.s.L.cph....th..........p.h.pp.l.K.P......Q......VD...c.........h..........h........h........s......s........G.............+....p........llLLAE..GRLVNLGsATG...........................................................................	0	375	679	903
+1134	PF03747	ADP_ribosyl_GH	ADP-ribosyl_GH;	ADP-ribosylglycohydrolase	Bateman A	anon	COG1397	Family	This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine [1]. The family also includes  dinitrogenase reductase activating glycohydrolase [2]. Most surprisingly the family also includes jellyfish crystallins [2], these proteins appear to have lost the presumed active site residues.	26.10	26.10	26.20	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.93	0.70	-4.63	176	3139	2009-01-15 18:05:59	2003-04-07 12:59:11	9	53	1913	22	1016	2670	767	273.20	22	79.26	CHANGED	GullGtAlGDALG....h.shEh...hshs..plp.t.ht............................................................hh.ht..htsGph.....T....DDTphslslsculhp..........................................th.....s..ps.........hhpc.hht...........Whp...............................t.shshG.....ssstpul...............pph...ht..ut......t.t........................................................................ssus.GuhMRssPl.ul..hh...........s.pph...hp.hutpsutlTHssspuhtuuhhhAhhltth.lpGp.....s...htphhttt..................................th..tppphtptlpthhphtppst.............................................htthtssshshcslshulhshhp................sss........apculhtsls....hGGDoDosuAlsGulhGAha.G.h....ps...lPpp..W	.................................................................................................................................................................................................................uslhGtslGDA.hG..........h.shEh..........hshp.........plp..t.hs.h..............................................................................h.h.....h.ttu...ph.......................T.......................DDTt..hslslscuLhpt............................................tth........s...ps.................hhpp.h.t..................Whp..................................h.ttshG..................ss..sptul....................................pth.......pp.....st.............t.......................................................................tuhsN....GusM..RlsPl..uh.......hhst..............shpph.................hp.hsths.......u....ph..THsp.....s..h.u.ltuuhsh...Ahhlths....lp..Gt.........s...hpphhpth..................................................................................................................tt..pht.t.plphhhphhpptt.............................................................................hht.h..t.sss....t.....sh.-.sl.s.sAlhhhht.......................................................sss..........................hpcsl..hh.sss....h.G.G.........DoDThuA.........hsGu.....lsGAha.G.h.....ps........ls.................................................................................................	0	390	677	884
+1135	PF04587	ADP_PFK_GK		ADP-specific Phosphofructokinase/Glucokinase conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4731 (release 7.5)	Family	In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilises two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase.  This conserved region is present at the C-terminal of both these proteins.  Interestingly this family contains sequences from higher eukaryotes. [1,2,3]. 	20.90	20.90	24.50	23.80	20.30	18.30	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.51	0.70	-6.27	9	234	2012-10-03 06:25:16	2003-04-07 12:59:11	10	6	153	7	154	223	1	386.20	27	87.69	CHANGED	slh+shulhhAYNsNlDAIh.hLpsE.....slp+hIpchGtcclh+t.EEhP+cIpp..-hlupllaul+pGKsAEl.lhs-c.l+pahtcpat..aDp.R....MGGQAGIhANlLuultshpVIsasPhLuKh.ApLF...sslhhPshEpGcLhLh..+E.acts-...sscIphIaEFp+G..FKlh..phpAP+usRFIsuuc.ps.s+l.h+--hpchLpEIuc.ps-hAIlSGhQulp.....ucstph.l+ps+EclplLpp.spsI+sHLEFAShs-cclRccll..plLshspSVGhsEsElApllplLGhc-LAccIhshsh.l.-ss.lhtuhlhL.c..s..............lchlphHTlhYhhhlT+tcs....EclccuLtFuslhAAs+AphGsIps.--l+.GLcVPhscpuphlcth.chcap.tcsh..h..........chc-YplshlPT+lVpcPhSTVGlGDTISouA.Flo.h	.....................................................................................................................................tlhluhssslDhlh.hl...........................ph.lpt...hs..h..p.h..........t.t..pph.....lps.t-l.htshhahhppGtuAEhhh.s...pp.hpphht...tht.......p..p........hGGs...Aulhupthu...h..t.s....hpV...lltsshhs+...tphh.....tt.l.hhP......tp...............................schHhIhEYptG....tphu....phpuPpuNRaIhspD.pN.sthp.....hh-.a.hp.........tLpc.......hp......sDlsllSGlp.hhc........s..p.s....tchhhccl...tc.l......p.lpp...spsl..l.HhEhAShsspclhpplhp.plh.PhVsSlGhNEpELh.lh...pshstsc.s.....h...thst..l..pss...l.chh...h...hlhcphs..................................LsR.lHhHTlsYphhhshpt.........hc.hppshthuuh.stssts.pt...........ss.hts...h-.s....c...h.s..L.chs..phhs.p.h..ct........c...h.h...p....tpsh.....h...........................pppshphhhsP.shlscpPh.p..TlGlGDsISutu.hh...........................................................................................................................	0	42	64	112
+1137	PF01117	Aerolysin		Aerolysin toxin	Finn RD, Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	This family represents the pore forming lobe of aerolysin.	24.30	24.30	24.60	24.70	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.28	0.70	-5.51	14	252	2012-10-01 20:43:00	2003-04-07 12:59:11	15	9	61	14	43	279	4	219.70	45	72.35	CHANGED	ss.h-VptcllspcspF.l+PluhL.AHhLGYAWsGGspupaVG.EDhslpRs....uD.uW.lpusssGs...CsGYR.CsE+hphplsNFpaslsspshpaGssp.pc+chlpTlsuhAhNpoDpspp.hllshphspoTsW.....SKTssashu-plthcspFcaP.hhG....cT-lslphpAsQsaoso.Nusopops.shpspspVPs+Sph.lplcla+oplshPYchph.hsYDl..phsGFLRWGGNAhh.sHPs.........NRPshsaTFs..hupspptupslhYQasH+hIsGps+aWDWsWslsc..GhushpaAhu....ssl.R.atuhloGpFpAtupasusI-hupshslsup.....phsphstpspttssshpl.hsshshcpLst	......................................................................................................................................................................t.t....h..h.hhN.sp..tp....hpht..h..ptsp...p..h.....shossht..hupp..lth..p.pa.phP..LsG...........coElulEluA..s..QSWAop..pG..GSTT.pol..S...ps...R..s...TVPs+SplPV+ltLYKusISYPY-FKAclp...................................................................................................................................................................................................................	0	15	29	36
+1138	PF05110	AF-4		AF-4 proto-oncoprotein	Moxon SJ	anon	Pfam-B_6407 (release 7.7)	Family	This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain.  Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].	29.90	29.90	30.20	30.70	28.90	29.80	hmmbuild  -o /dev/null HMM SEED	1191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.23	0.70	-14.19	0.70	-6.69	6	483	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	78	0	208	431	0	610.70	28	90.08	CHANGED	Yc-DRNlLRh+E+ERRNQEsQQ-c-AFPsshPLFuEPYK....TuKGDcLSSRIQsMLGNYDEMK-FLos+Sp.s+LsuhPpssss.SsscKscPpah.s-pRuputsuS.......pQSs+sossGPsPs.....ushSpSpKtops.....sS.+s+uussPuo..uoQc+spp........ptspp+tpupptu...-pu.p+p.SPhhuplspssss............pppuSS+..s..puusssuKpphpuKSP+-h-sshps.ppP.suhs.......uSuQhssQsF.PPSLhSKousMQQKPTAYVRPMDGQDQAPsESPELKsS...tEsYusQSapss.s-hKssA..KAKLoKL+IPSQslEsshSs-ssCVEEILKEMTHSWPPPLTAIHTPu+sEPSKFPFPTK-SQalosuoppQKphDsss+opsssppsp.SMLEDDLKLSSSEDSDsEQss..............-KsssRssP...sssspspsEsussu+uuSu.ScSsSESSSuSDSESESSSSDS...EsNEP.csuoPEPEPPoTNKWQLDNWLsKVssppss........PsusssopsPppps.cscG+spususp..s-s+-s..pSos+sttcsRsspKuPcsG+s+.QKSPspu....................-..sstRRolGKKQPKKsEKssus-t.psuh+sEpEsu..shtpusphssc+sKspTKGsp+sus+KEPKsulsss................uEK+KaKuso+sssKS+EhlE..TDSSoScSspc.......cuLP.......ssopSsGsscSspt.........RTsss.pushspssht+pp.....hhlPhc-sELLSPL+Ds-shps........LhVKIDLsLLSRIPt+.P.tcus.s+sscccs.stsp+csScstSEKuSsKuKRK+Ks-p-sctsspKKs+lEccsp........osuss.uspcsSps+sSpppStsKcc-hLPsP.u...Plsspo.Kst+su.KRshsppsosusssPpusspspSussssossKp++sEuKGusopctt+ssSsssssp...................................................................hPlPsLosusoKspRsKLsFDD.spsADaaMQEAKKLKHKADAhsD+FGKAlpYL-AVLSFIECGNAhEpsu.EuKSPYsMYSETV-LI+YsM+LKsauuPsAostDKpLAVLChRCpSLLYhRMF+LKKDpAlKYS+TLsEHFK.NSSKsAQAPSPsh...........u+usGsPSPlS.PpsSPuoSVGspSuuuSu.uusu..uoVoIPQ+IHpMAASYVsITSslLpAa-lW-QAEpLo+ENKEFFu-LDplMGPLshNSS.Ms-LV+.......YoRQGLphLRpsA+	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	20	34	93
+1139	PF03969	AFG1_ATPase		AFG1-like ATPase	Bateman A	anon	COG1485	Family	This family of proteins contains a P-loop motif and are predicted to be ATPases.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.27	0.70	-5.65	8	2702	2012-10-05 12:31:08	2003-04-07 12:59:11	11	19	1983	0	969	3282	2551	309.70	33	88.96	CHANGED	sTshpRY.pppLppsshhtDsAQusAlssL-cLtp...cltsushs+.t.....thhttLau+K...sttss+GLYlWGGVGRGKTaLMDsFFcuLPsppKtRsHFHcFMhcVH--LppLp..............ttsDPls.suDchss-splLCFDEFpVoDIuDAMlLupLhcALFsRGVoLVATSNhsPcsLY+sGLpRpcFLPtIshlcs+hpllsVDushDYRLRsLppA.hahhP.sttsptthsthapthh...ut.pstssL-lsuRtlps.ssssslstauFssLCpsspuspDYlsLuctFpTVhLssV.sMs.sccstA+RFIsLVDclYDpcl+LllS...AEs.hp-LYpuGch..tFEFpRshSRLhEMpS....t-alsRt	.................................................................................................t.a..t.lt..th.....D.s..hQtthh.t.t.hp.hhp....................th......t.......t.........t.........................hht.t.h........h...t................t.......................t......................ts...........s.........+...............G...LYhaG.sV.G.pGKTh....L.M....D....h....F....ap..s.l......P..................h.............p..........p..........K.......h..R...h...H...F.....H...pF.M..h....c.lH.p..clpt.lp.........................................................................s..p..t..sP..l...t...l.A.c....p.h.......t....tc.......s..p..l.LCFD...E...F.......V...o....D.I...s....D...A......M....l..Lu..p.......L...h...p...t.L....F...t..p...G..l..s...lVAT.SNh..sP...-...p...L......Y.......c...s....GL.pR..t..p.F.L..P.t.....I....sh.lpp..phplhp.l..D...u......s.....h.DYR....h.........c...............s...h...p....t........s.......t......h.......ah.........P..........h..........s......t..............p..........s..........p.........t..........t...........h.p.......p.......h...........a.......t..lss.....................t..t....t.........t.....s......................s.............l...p.......l...t......t.......R...l.....ts....................t...h..s..s..........t......s...h..hhsFtpL..C............t...........s..hutt.DYltLuchac...s.lhltsVPhhs.................................c..stA...RRFlsLlDthY..-pcl+Llho..............................Atssh.cl....a............t....tth...................thcatRshSRL.EMpst............................................................................................................................	2	276	558	798
+1140	PF01314	AFOR_C	AFOR; 	Aldehyde ferredoxin oxidoreductase, domains 2 & 3	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible  oxidation of aldehydes to their corresponding carboxylic acids  with their accompanying reduction of the redox protein ferredoxin.  This family is composed of two structural domains that bind the  tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR [1].	19.60	19.60	19.90	21.70	19.00	19.50	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.39	0.70	-5.78	112	1171	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	639	10	535	982	251	383.30	27	62.78	CHANGED	htchhpchhctlp...ssssht....shtpaGTssh.lphhs......phGshPs+Nap....puth..c............tAccluG-t.hpc.......phh.hppt....u......ChuCslsCu+.hschp.................................u.h..............................stsPEY..EshhuhGuss.....................GlsDlculhphNcLsschGlDoIShGssluhsMEhhE+Gh...ltct.h........shtlp.aGss-ullchlcclAhRcG.lGchLApGstchucch..G.s.-...hu..h.pV......K....Gh.EhPuaDPRuhp...G...huLuYATusRGusHl..cu........a.shs.-hh.......s.................thD.h.............th...........csKs.phlthhpchpul.....hDShslCtFssh.................................hshpth...............................schlsAsTGhc.hos--lhps.GERIasLcRhaNl.+t......G....hst.pcDsLPpRh..hcc.......Ph.pGs..scGp.....lsp..lcchLscYYchRGWc.ppGhPot-pLccLGL	...............................................................................................................hhtp..chl....pss.sh.....s.tphGTshh..l.hhs......ctGtlPstNhp.............psta....p..............htpthshts....htc...........phh....s+....hp....u...........C......a.uCPltCtp..hp.h...........................................................ps.Ea..-slhuhGuss....................................................s...sc.ltss..h..hs.pl....s--hGlDs..hshG.p.hhu...hhh-h...hp+...Glhpc..........................h.tl..c...h...GD..sph..hh..c.hh...c.lApR......pG...hhshLA.c.G....sht....h....Acp..a........s..sp-..........hh......h..hs................................K.....sh.th.P.....sac.s.pthp.....G.....h.l.s.hhh.sp.c.s.t.sHh.ch...............................h.hlth-lh.................G.................tthD.h.....p....................-uKh.chsth.t.h.s.sl.....hsulslCt.ash......s.............................hsh.th.h............................................schhpA...h.TG.c..hot-c.L...hh.u-RIhsLcRtash+h..h...........h.pp.pcD..hlP..phh..hcc.............................sh.s...p..Gs..tp........hsct.hct.Ls.aYp.hGWs.p.G.hPstppLpcLsl.......................................................................................................................................................	0	220	395	470
+1141	PF02730	AFOR_N		Aldehyde ferredoxin oxidoreductase, N-terminal domain	Finn RD, Bateman A, Marshall M	anon	Sarah Teichmann	Domain	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This domain interacts with the tungsten cofactor [1].	20.80	20.80	29.70	34.50	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.13	0.71	-4.98	111	1162	2009-09-12 00:12:13	2003-04-07 12:59:11	10	5	646	10	533	979	183	199.10	39	32.36	CHANGED	atG...+lL+VsLostphph-plstc.hh+palGG+GLus+ll.hccl.ss.........psDPLuP-.NhLlassGPLTGo..sPsuuRhslss.KS....PLTG..........slssSssGGtauspLKhAGaD..ulllcG+uccPV...YLhIc.cs........plElc-AscLW....G.pssh-TpctLpcch.......t.................spVhsIGPAGEphVtaAsIhs....-t..tR.......uAGRu.GhGAV.MGSKpLKAIsV+....Gsp	........................ahsplLRVsLos...s....slphE....chsc...hcpalGGhGhuh+lha-cl..ss.........sscP.h.s.p..NtLlFusGPLoGos.sPs.ouRhslss..hS..........PhTs..........hls-uphGG.hausphKhA..GaD..slllcG..+..u..c..pPV...a..LhIc..--...........c..Vpl....c..c.....A..s...t..LW.........G......csshtTsctlpcth.s...c......................ssVssIG.AGEN..hV...h.uslhs........sp......p+................uG.RuGsGAV..M.G.S.KNLKAIsVcGs................................	0	222	394	469
+1142	PF02420	AFP		Insect antifreeze protein repeat	Bateman A	anon	[1]	Repeat	This family of extracellular proteins is involved in stopping the formation of ice crystals at low temperatures. The proteins are composed of a 12 residue repeat that forms a structural repeat. The structure of the repeats is a beta helix [1]. Each repeat contains two cys residues that form a disulphide bridge.	36.50	2.00	36.60	2.50	35.20	1.90	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.25	0.75	-6.12	0.75	-3.10	9	502	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	7	21	7	518	0	11.70	45	80.61	CHANGED	TCTsSpsCspAp	..sCTsSssCspA....	0	0	7	7
+1143	PF03756	AfsA	AfsA_repeat; 	A-factor biosynthesis hotdog domain	Yeats C, Bateman A	anon	Yeats C	Domain	The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain [2].	21.30	21.30	21.30	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.60	0.71	-4.43	34	276	2012-10-02 20:54:35	2003-04-07 12:59:11	8	5	116	0	114	312	5	127.30	20	65.85	CHANGED	hVHRtsss-VlLossppt.....sththphphspsHshhas+...ssDHhsuhLlhEuhRQuuhhlsHsth.tlshshthlhhshshsatchschss.....Pshlpspssssssp.......t...sphphplslhQsGpllusushssss	.................................VtRt.pstpVllsshtph.........sth........ph.th.p.h........s..psHshhh-+.....ssc...H..hsshl.LhEusRQsuhh..hs...ptth.....hs...............t....h..lhp.s.h...s.hshpp.hs.phss........Psplpspss.ssshp..............tthph..phphhpsuphsspsphph..h................................................	0	16	76	106
+1144	PF04671	Ag332		Erythrocyte membrane-associated giant protein antigen 332 	Waterfield DI, Finn RD	anon	Pfam-B_4587 (release 7.5)	Repeat	To date many different Plasmodium antigens recognised by the hyperimmune system human sera have been cloned, sequenced and characterised.  The majority contain tandemly repeated amino acid sequences which make up a considerable portion of the protein sequence. It has been suggested that these repeat-containing antigens may provide an immunological 'smokescreen' to the parasite in order to evade the human immune system. This repeat is found exclusively in the Plasmodium falciparum Ag332 protein and occupies most of its length [1].	20.70	20.70	61.00	20.70	18.40	20.60	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.49	0.73	-6.65	0.73	-4.03	41	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	2	0	29	71	0	21.20	52	11.32	CHANGED	sSlsEEllE.-GSsTE-lVppc	.sSloEEIVE.-GSsTE-lVcpp.	0	29	29	29
+1145	PF01453	B_lectin	Agglutinin; MMBL2; MMBL; Agglutinin;	D-mannose binding lectin	Bateman A, Griffiths-Jones SR, Studholme DJ	anon	Prodom_2511 (release 99.1)	Domain	These proteins include mannose-specific lectins from plants[1] as well as bacteriocins from bacteria [2].	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.15	0.71	-4.19	128	2897	2009-09-13 13:36:34	2003-04-07 12:59:11	19	158	299	65	1397	2960	33	103.90	30	18.28	CHANGED	spshlW.....ANpt.....pPl..................s.pLplpt.DGs..LVLh.s..ss..........................t....lWuo..........ssssss..sssh....spL.c.sGNLVl.h....t.............sspslWpS.......F..cpP.scohLsstph....t.hs.t.p....hsuWposs...........ssu	...........................................thlW....hANpp...............pPl.............s........upLplst...s...Gs.........LVLh...s..ts..........................sps...lWoo.......................sos..sts.....tssh..........upLh...c.sGNLVlt...s..s................ssphlW...Q.S.......F...DaP..oDTlLPt.pls.h..s.hh...t.t........hhshts.....................................................	0	123	873	1179
+1146	PF05039	Agouti	agouti; 	Agouti protein	Moxon SJ	anon	Pfam-B_5381 (release 7.7)	Family	The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation [1] [2].	21.80	21.80	21.90	21.80	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.33	0.72	-10.99	0.72	-3.64	9	278	2012-10-01 22:06:18	2003-04-07 12:59:11	7	1	126	6	49	243	1	92.60	45	71.89	CHANGED	tcu-pth.............plsshuLs.slcphstpptcpc....p+hshhc.phLs.......R.s..sPpRCltLt-SChu.tsPCCDPCAoCaCRhFpshCYCRph	.................................................s....p.h..s..........pluhl..uLppc.Kphohp.EAEtp......p+.ph.pc..s..p..thphA.......tsRss....sPpsCVsp+-SChs.ssssCCDPCAoCpCRFFpohC.CRh.h.....	0	2	4	16
+1147	PF04647	AgrB		Accessory gene regulator B	Finn RD	anon	Pfam-B_5200 (release 7.5)	Family	The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system.  AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing.  AgrB is a transmembrane protein [1].	23.00	23.00	28.30	28.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.36	0.71	-5.22	56	789	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	539	0	119	491	7	179.40	24	93.29	CHANGED	pl.scphsphl....tpptslscpchthlpYGhpllltslhKhlhlllluhlhshhh.sllhhlshhhlRhauGGhHupo.hpChlholhhhlshshls.thhthshh......hhlhh.....hlhuhlllhhaAPssotp+Pltspc....hc+phKhtulhhhhlhhllslhlh.............hhphlhhulhhpsls..lhslsh..phhp	.....................hhcphuphl....ppcpsl-.c...ph.hlcaGhpllhtslhphllhhhluhlh.shhh.ollshlsahhlRpautGhHApophhChl.olllalh....h....shlh.hp...h.p.lshh........hhlhl....hllulhllhha....APssocpp.Pl.stc....hh+p..h...Kh..h...ullh...h..h..lhh...l.ls.Lhlh.............hsphlhh.Glll.psls..lhPlhh.h..p...............................	0	69	107	116
+1148	PF04730	Agro_virD5		Agrobacterium VirD5 protein	Mifsud W	anon	Pfam-B_3261 (release 7.5)	Family	The virD operon in Agrobacterium encodes a site-specific endonuclease, and a number of other poorly characterised products. This family represents the VirD5 protein.	25.00	25.00	628.50	219.50	17.30	20.70	hmmbuild  -o /dev/null HMM SEED	774	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.53	0.70	-13.41	0.70	-6.48	5	19	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	5	0	4	20	0	432.90	50	93.94	CHANGED	KLGAAERuAYEsWssusRPTWKDLIL+ARLDAIDSSAWLsDl.......................................................................................................................................uEsTSSTFcYEGlPLGEGER+AYEcWQEDAQPTWE-LVVNARlsELs+suuIssEasuLpEshEhRSDAsKRKRccsIDQ+so.SuSFpYDGMRLGuPERtAhtsWucspPPo.p-LllcuRlpuIssSsWh.sp.ssoS.FEYpGhPLGpsER.AhcpW.tsAQPsWEDLVVsARh...AELh.uu.h.sp+...p.tt-.s.ptp.Rh..hPI.tcp.sts.FlYDGhtLGAsERAAY-RWSKP-RPTWEDLILDARQAAIESDuVSsstIGKoSSSVFLYEGMSLGDAERQAYGRWRQPAQPRWQNLVVNARLAELDPSAWIPDEHDPFE-GEAsuhsSQASsANKSssuLGsQS-S+RPuhA+EssQEsTHlQsPoCSQLETRRALaFGSSGRDAspTESIAcsNRlDGVGKVKRLGoKSRRuVsATsHuVsSSscRLLS-EsGppAssSsPEKsVRSRoDNIGTYGSRKNERARLATETGKYESEHIFGFKVVHDTLRATKEGRRLERPMPAYLECKELHRQHVGTGRGRTRLVGRGWPDDASYRSDQRATLSDPVASuEGATASNGYQLNQLGYAHQLANDGLQSETPDGVsMPIQVATTSYNYTVSRDPVLSPPSKEQAPQLLHLGPRGQTEAVLARETALTGKWPTLEREQQVYREFLALYDVKKDLEAKsLGVRQKKpALVSALNRTAuLIGASPhKAQSssAEVEpusDEhDERRVYDPRDRuRDKAFsR	......................ERtAY-sWstst.PTWKDLllpARlssIDussW..phtEsosSsFhYEGlPLGEGERpAYcpWtEsAQPoWEcLVlsARhtpLstst.IssEhssLpps.phRu-u.K+phpp.hDpcps.stuF.aDGM+LGpPE+tAYt...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	4	4
+1149	PF00578	AhpC-TSA		AhpC/TSA family	Bateman A	anon	MRC-LMB Genome group	Domain	This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA). 	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.35	0.71	-4.44	124	16547	2012-10-03 14:45:55	2003-04-07 12:59:11	16	104	4711	453	5334	26489	14345	127.90	25	62.99	CHANGED	lGppA.P..-..Fplt.......st..p...s...pp.lsL.s-h...pG..phllLhF...ast.sasssCs.pEhsshpchh.pcap.pt.ss.pllulSs.Dsht.........stppahcphp.................lsaPlluD....sppluctYGlh............................hshtssalIDtc....Ghlphh	...................................................up.s.P..s...F.p.ht...............st....p.........h......pp...l.s..l....s-h................pG.......+h.s.l...l...h....F..................a.....Pt...s.....aT.......s....s...............Cs.....s....E..h..s...s....h...p......c....h...h......p.....c...a......p......p..........t......s.......s......p.....l......l..u...l......S......s.....D...s..ht.............................sp..p...s.a...t.p.ptp..................................................ls..a..s...l....l......u...D.............s...p.....p......l....s....c...t...a..s.l.h..t.................................................................h.s.hR...s....o....F.l...l.Ds.c...Ghlp..h..........................................................................................................	1	1910	3591	4647
+1150	PF02626	AHS2	DUF183; 	Allophanate hydrolase subunit 2	Mian N, Bateman A	anon	COG1984	Family	This domain forms the second subunit of allophanate hydrolase. In yeast urea amidolyase (Swiss:P32528) this domain is found between Pfam:PF00289 and Pfam:PF00364.	25.00	25.00	25.10	25.90	23.60	24.70	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.44	0.70	-5.10	160	3169	2009-01-15 18:05:59	2003-04-07 12:59:11	10	21	2343	11	754	2303	1607	265.10	35	59.05	CHANGED	chGlssuGAhDthAhphANtLlGNs..sssAslElshs..Gsplch.ppssh.lAlTGAshsspl..........sG...ps.....lsha.pshtlpsGshLpluts.p..pGsRu.YLAltGGl.sls.hlG.SpSThhtuslGGh........tGc.sLpsGDhLslsssssttstht.........................h..thhsthsp..pht.l.RVl.GPph..chFoppshppahsspaplosposRMGhRL..p....Gs.slp............spstslhS-ulsh.GulQlPssGpPIlLhsDpQTsGGYP+IusVlssDLs+LAQhpPG.spl+FphlshppA	............................hGls.uGAhDphAhchANhLVGNs..tssuuLEl.Tl.........t....sssl....cF....p....s....s.sh.lAlTG.As.h.p.spL.............................-s.....ps........l.....hh..pshhlctGphLpl.........sts...p......pG....hRu.YLAV.uG.G.l....s.........V.ss.h..h.G.SpSTphpuulGGh........pGR...hLpsGDhL.slspsttthttht..........................................h..h....p...h.st........sst..l..+ll.GPph..chFscpuhpsFh.p.s.s.........aplospSsRhGhRL....p.........Gt..hhp.....................tpsp-lhS.cu.hsh.GslQVPssGpPIlLhsDt.TsGGYPpIusl.hpsDL.+LAQ.htsG.spl+Fh.hshpp.....................................	0	197	420	621
+1151	PF01808	AICARFT_IMPCHas		AICARFT/IMPCHase bienzyme	Bashton M, Bateman A, Iyer LM, Zhang D, Aravind L	anon	Pfam-B_1613 (release 4.2)	Family	This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide  ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate [1]. This is catalysed by a pair of C-terminal deaminase fold domains in the protein [3], where the active site is formed by the dimeric interface of two monomeric units [3]. The last  step is catalysed by the N-terminal IMP (Inosine monophosphate)  cyclohydrolase domain EC:3.5.4.10 (IMPCHase), cyclizing FAICAR  (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP [1]. 	25.00	25.00	25.00	25.90	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.91	0.70	-5.33	9	4880	2012-10-02 00:10:39	2003-04-07 12:59:11	13	11	4399	36	1208	3788	3760	297.20	42	60.59	CHANGED	AAKNHtcVsIlsDPtDYssllpchcp.pGp.lohppRpcLAhKAFpHTAtYDusIusaFpp.hu..............tt.s...shshhcp.sLRYGENPHQpu.hhhphs.tch....lssAp.LpGKthSYNNlhDADuAhphV+Eap.....PAsshlKHsNPCGlAlG.....................sslt-AYsRAhpAD.hSuFGGlIAhNccVDstTAchIpp...........FsEllIAPuYstEALclLs+K.KNlRllhhthssph...ph-h+pVtGGhLhQcpD...tshhstsphp.lVoKppss..EppLpDLlhAWpslKasKSNAlVhAKNshslGlGAGQ.SRVcus+lAh.KA	.........................................AAKNats....VsllscssDYstllpclp........t.....t.....G..s.....hoh..pp.....RhpLAhKAFpHTAsYDuhIusYhsp......hs................................................t.t.h..P..p.t...h...sh.sh.....p....p.p.shRYGENPHQpAuaYhp..st..s.t.p................u.l..A.s.......A.....c...QL........p..G.Kt.LSYNNltDsDAAhch....V+-F..s............................pPAsshlKH.....sN....PC.GlAlu.......................................s.s.lhpAYp...+Aa......tsDshSuFGGIlAhNRpl.D.ttTAct...ltp.......................FhEllIAPuasp-A.LclL...st....K....K....NlRlLt......h..........s..............................s.....p...............t.................s.......t........h-.....h......+.p.V.s..G.G.lLlQ.........sp..D.................h.h.h...s.......t...p.h.........p...........lV.T..........c........+...p.................P.............o....-p................ch.....pDLh.FAW+ss.KaVKSNAI..lh...u.........+.....s...s.....h....TlG...lGAGQhsRV....tSs.+.lAht+.............................................	0	404	789	1035
+1152	PF04548	AIG1		AIG1 family	Bateman A	anon	Pfam-B_1846 (release 7.5)	Family	Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.37	0.70	-5.23	32	1778	2012-10-05 12:31:08	2003-04-07 12:59:11	11	41	154	28	1094	11277	2366	173.00	24	40.10	CHANGED	hsllLVG+TGsGKSATGNSI.....LGccs.....FpS+hpupuVTppCpttss.p.cG...pplsVIDTPG...L.F-hp.s..s...s-.hs+EIh+ChhLupsG.HAlL....LV..hslt.RhTpE-ppslpplptlFGsplhcahIllFTpt--Ltsss..L-DYlppssschLppllp.CssRhshFsN+..ssttc+tpQlppLLshVpslhppNs..G.t.aosc.hacphpppt....p.thpppp	.............................................pllllG+.oGsGKS....uh....sN....ol...........................L..G..p....p.h.......................F...p.......s....p....h......s.........s....p......s.....s........T......p.....p....s......p.......t....t...........p.......t.......p........h......p..G...................p.p..l........s.......l.l..DTPG..........h....h....cs...p...h......p......p.p...p....h..h..p...p...l.....h...p.....t...h............h........p...t...s.....u.........c.....s....h.l......lV.....h.p..hs.....+h.o...p..p.....-.p.....p..h.....l.p....h.....l.p...p...h....F......G.........p...p......h..h..c...h...s..l.l..l..h..T..p......t..c...p.....h.....t..s...tt........hp..p....h...ht......................h......t.l.....h.t....h...t.............................................................................................................................ttt.................................................................................................................................................	1	345	637	860
+1153	PF00731	AIRC		AIR carboxylase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_462 (release 2.1)	Domain	Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	29.30	29.30	29.80	29.70	28.80	29.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.83	0.71	-4.93	224	5292	2009-01-15 18:05:59	2003-04-07 12:59:11	15	19	4504	106	1483	3728	2423	147.40	46	73.54	CHANGED	shVuIlMGScSDhssM.......ccAsclLcc.hG..............lsaEscVlSAHRTP-chhcaAcsAcp.+GlcVIIAGAGG.AAHLPGMlAuhT.sLPVIGVPVp........op.sLsGhDSLLSIVQMPsGlPVATlAIG..GApNAuLLAspILuhp....Dsp.ltp+LppaRpphpppV	.................................................hVullMGSpSDas.sM.......pcAu.p.h.L.-p..hu....................ls....a....E....s....c.V...lSAHRTP-hhhpaAcpAcp...+G...h..c..V.IIAGAGG.AAHL.PGMlAuhT.slPVIGV..P.Vp..............op...s...L...sGhDSLhSIVQMPs...Gl..P..V..A..T..l..AIG.....sGAtNAuLLAspILuh..p....c.p.....lt....p+lttacpt.pp...................................................	0	517	988	1277
+1154	PF00586	AIRS		AIR synthase related protein, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome Group	Domain	This family includes Hydrogen expression/formation protein  HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain [1].	21.00	11.40	21.10	11.40	20.60	11.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.29	0.72	-3.75	856	17593	2009-01-15 18:05:59	2003-04-07 12:59:11	19	63	4701	78	4854	13670	7415	103.20	23	21.07	CHANGED	G.-DuAllchs....................................sttlshss.Dshsstsp...........h.sshs...hGtpulusslsDls..uhGA.cPl.shhsslsh.......t.........t.........................................l.pphlpGhscssp..phGs...sllGGco	....................................................................................tsuulhp.ls...................................tptt.ls..hssDth.s..s....psc.......................t.ps.hs....hGtpulusslsDlh................shG..A..c.P.........l...hh.hshlsh............sp.h...ssp.h...........................................h.ptllp.....Ghuptsp...ph..Gh.......sllGGcs.......................................................	0	1572	3133	4132
+1155	PF02769	AIRS_C		AIR synthase related protein, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome Group	Domain	This family includes Hydrogen expression/formation protein  HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.95	0.71	-4.21	169	19206	2009-01-15 18:05:59	2003-04-07 12:59:11	17	69	4747	77	5269	15059	7896	157.80	18	34.84	CHANGED	psGDhllhlus........sGltusuhhtttphhttss.................hs-hhhp.phlhhhhhhhth....thlpuhpDlosGGLssslsEhs.t.sthGhplshs........................shhp.h............h-hhhs..................................tspGthhlslssppt....pphhphhp..pht......shhlGplssptththhht	...................................................................................sGshllhhus......................Ght..usu....h..s...h..h...p..p.h.h.t.tss.h................................................hscsh.h..p.......p.h..hp.....s...h..tt....hhth...............shl.....p..uhpDlo.sGGL...h.....s............slsc.....hs...t..s.....u......t......h........usp...l.chs..................................h.shh..p.h..............................t.h-...h.h.hs......................................................................................................tsp....u...t....h.....l.l.s...l...ssppt.........p..thh.t.h.hp........p..t.sh.........t.....shhIGplspptt......ht..................................................................................................................	0	1677	3348	4466
+1156	PF04988	AKAP95		A-kinase anchoring protein 95 (AKAP95)	Moxon SJ	anon	Pfam-B_5366 (release 7.6)	Family	A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic  chromosome condensation by acting as a targeting molecule for the  condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA [1].	24.40	24.40	24.40	26.90	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.47	9	156	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	41	0	77	134	1	157.10	53	28.51	CHANGED	FsCShCKFRTFp-c-IppHhpSshH+Epl+al..ps+LsK.sh-FLpEYlsNKhKKTtpc+pphpsppthhpph...tDlhcGlu.-cFMpKVEAsHCuACDlaIPshapslQcHL+S.sHspNR+thhEQhK+sSlhsA+SILNN+hltp+LE+YlKGENPFssssc-	.....................FsCSlCKFRoFp-cEIppHL-S+FHKEph+aI..uTKLPKpTs-FLQEYlsNKsKKT-pR+pphpsppsshpph..-pDlhculu..hEHFh+KVEAA...HCuACDlaIPhpasllQ+HLKSsDHN+NR+hhhEQ.K+sSLhVA+SIL...NN+hIsc+LE+YLKGENPFssps..t................	0	3	8	28
+1157	PF02983	Pro_Al_protease	AL_protease; 	Alpha-lytic protease prodomain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.50	20.50	21.10	21.10	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.07	0.72	-4.01	35	302	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	88	14	99	313	0	59.80	28	15.82	CHANGED	polucLcuspssL.s........sush...susuWaVDspoNcVVVsucsss...uusshschuussuutss	........................ohspLcuupspL.s.............sAsh......ssou..WhVDspoNpVVVs.sssss.....susphsphstssss.s.t......................	0	32	73	96
+1159	PF00490	ALAD		Delta-aminolevulinic acid dehydratase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.90	21.90	22.50	23.40	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.83	0.70	-5.54	165	3912	2012-10-03 05:58:16	2003-04-07 12:59:11	16	9	3698	72	1117	2899	2727	314.40	48	95.89	CHANGED	hshpR.RRhRpstslRclVpE.TpLsssDLIhPlFVp-Gps...pp.IsSMPGlhRhS.l.DpLhcpsccshplGIsulhLFGl...s.pt..KDttGopA..as.ssGllpcAlRtlKcth.P-.lhllsDVsLstYTsHGHsGll......................t..s..pl.NDtTlchLs+tAlupAcAGADllAPSDMMDGRVuAIRpALDps.GapclsIMSYuAKYASuFYGPFR-AssSu..sphG.............D++oYQMDP.A.NscEAlREltLDlpEGADhlMVKPuhsYLDll+cl+cpa.s...lPlsAYpVSGEYAMlKAAAp..pGWlD.cccllhEoLhuhKRAGADhIlTYaAh-sA..c.hL	.......................h..hpR.RRlRpsshhRphl.p..E..s....p.L.s.........s..sDLIhPlFVh..........-G..p.s......p..ptl..sSMPGVh.Rh......o......l..-.pLh.ccscchsp....hGItu.lhLFGl......s.pp....KDtt...GopA..as..-.Gllp+AlR.t.lKpp..h..P-.l.........hlhsDlCLstYTsHGHCGll....................csu..tV.NDtTlchLs+pAlu.....pAcAGADllAPSsMMDGplsAIRpALDp......s...G.a.p.s..ssIMuYosK..YASu...FYGPF.R.........DAssSu..sp.hG.............DRKoYQMDPu.N.p.cEAlREsthDltEGADhlMVKPuhsYLDllRcl+-...ph....p....lPlsAYQVSGEYAMlKAAAt...sGW.lD.cccllhE..oLhuhKRA..GADhIlTYaAh-sAch..........................................	0	362	710	948
+1160	PF00171	Aldedh	aldedh; 	Aldehyde dehydrogenase family	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases Swiss:P00352 EC:1.2.1.3. Succinate-semialdehyde dehydrogenase Swiss:P25526 EC:1.2.1.16. Lactaldehyde dehydrogenase Swiss:P25553 EC:1.2.1.22. Benzaldehyde dehydrogenase Swiss:P43503 EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase Swiss:Q02252 EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase Swiss:P81406 EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase Swiss:P30038 EC: 1.5.1.12. Acetaldehyde dehydrogenase Swiss:P17547 EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase Swiss:P07004 EC:1.2.1.41. This family also includes omega crystallin Swiss:P30842 an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.37	0.70	-6.16	119	43773	2012-10-02 17:28:28	2003-04-07 12:59:11	17	120	5325	607	12917	36315	23835	407.20	25	80.35	CHANGED	ahsups.......pp.hpshsPu.....sschlupls.tustp.Dl-pAlpuAcp.Ahp.......t...W.pphsstcRuplLt+hAchlc.p+t--lApl.sh-sGKslt...pupt.-ls.ts.....hshhcaaAsh..scc.hpG.ph......hs..s..........sthshsh+p.Pl.GVlusIsPWNaPlhhs.shKluPALAsGNolVlK.Pup.TPlou.hhluclhp-.A....GlPsGVlNll...sG..GppsGpsls.pcsplctloFTGSotsGcplhpt.Au..pp...l....K+lsLELGGKs.....shIVhsDA.D.l.-tAlpsslhut.ahssGQsChusoRllVpcu.la-c..Flcclspts.ppl.clGs...P.h-..........ssplGPllsppphc+lpphlppuhpcGAclls.GG..............tpG.halpPTlh...ss.VsschplhpEElFGPVlslhpac..s.......-EA.lphANsopYGLuuulaTpDls+uhchucpl..csGtValNsh...tsss.ts..PFGGhKpSG.hG..R-sG.ttulcpasphKsl	.......................................................................................................................................................................................................h.sP.............st.p....h..t..t...h..........s...........s......t...c.l..p.t.A.l....t..s...A..pt...Aht.......................t.W...t.p..h..s...s..t.p...........R........s........p....h...L........t..........c.h........u........p............h..l..........p........p........p...........t..........c......p.....l..........u.......t........h................s........h.........-..........t........G............K..s..ht..............p.uts........-....lt....t.s.......................h.p.h.h.....c.a..h..u...th.......sc...p.....h......t.....s....ph..............................h....t...............tshh..s.h.h.h.p...p.....P..l....G....V........l....us..I............s..P...a..N....a....Ph......h...h...s...s..h.ph..u....s.A............L..s..s..G.N.s..l..l.l....K....P.u.....p....p....s.....s.....h....s....s.....h.....h....l.....s.....c.....l....h....p....c....A......................G.l.P...t...G...l....l..s.l.l............t.G.......u.....t....p.....s.....u...p...t...L........h....p..c.......s...t...l....sh..............l..............s......F.T..G....S.s..t.....s........G..c....t..l.....h........p.....t...uu........tp........h..................p....l..hhE......h........G.Gp..s.....s.h.l.....V......h.....s........-......A.......D......l.......-.....t.....A...l...p.......s.h...h..t..........u...t.....h.......h..s....s...GQ.......h.C.......s...u..s.p...p.........l.l.V..p.........c.........s.........l.........h......-.p.........hhpt...l.........h.......t.t.......h.....p......p......h.......p....h......G.s......s...hp........................ts...t...h..G.s.....l...l......s.t.t........t.h..p....p..l.............t.h...l...p...t...u...h....t......p.....G......u...p.....l...h.h....uG.............................tt........G....h.a...ht.P....T.....lh...................t...t....s.t............p......h.....t...l....h.....p............c.....E..........h..F.....G.....P.....lhs..........l.h.t.hp.....s...............................c...-..s.....l....t....h....s.....N....s....s....t...............a....G..L.....s.........u...s.........l.......a.....o......p......s........h......t......p......s..........h......p.....................h...t.......p...t.l..........cs....G.........h.....l..............h........l.......Nt..........................s................h................s........FG.................G....h........t..t..S...........G....h.G....pt.u....s.ht.a.p.p................................................................................................................................................................	0	3478	7376	10497
+1161	PF01081	Aldolase		KDPG and KHG aldolase	Finn RD, Bateman A	anon	Prosite	Family	This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate  aldolase (KDPG-aldolase)	22.20	22.20	22.30	23.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.02	0.71	-5.14	5	4204	2012-10-03 05:58:16	2003-04-07 12:59:11	14	12	2642	49	825	2763	739	192.20	33	90.12	CHANGED	I-ulL+cA+llPVIslcct-DAlPlA-ALlAGGlRVLEVTLRTpsAlDAI+hlt+pRP-hlVGAGTVLsApQlupApcAGAQFlVSPGLTsDLlKtus-schPLlPGVuTPSEIMlGL-hGlccFKFFPAEssGGVsAlKAlAGPFuQVRFCPTGGIsPuNlRDYLAlPullClGGSWlVsuuhlpssDas+IspL	..........................................h....hppt.sllsVlts.ps.h.-cA.lshucAL.lpGG.lp.s.lElTh......p......o......s.....s......A....h......c........u....I....c....t...l....t.................c........p.....h.....s....c.........s.l.l..GAGTVLssp..psctsh.pAGA...pFlVSP.u.h.st...pllctsp.p.t....slP......hlPGssTsoElhtAh.-hGh.chlKhF..PA..p..sh..G.....ss..hl+Alt..u..P..h.s..p..l..p.h.h.P.TGGlo..s..s..N..htcalshs.s.lss.s.hG.S.hL.ss.ts....t.t.tpattlt..................................	0	228	513	683
+1162	PF00596	Aldolase_II	Aldolase_class_II; 	Class II Aldolase and Adducin N-terminal domain	Bateman A	anon	MRC-LMB Genome Group	Domain	This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.46	0.71	-4.68	502	9699	2009-01-15 18:05:59	2003-04-07 12:59:11	16	32	3654	97	2299	6508	3435	184.40	24	69.68	CHANGED	pc.l....stss+hhs.phGh.sp.ussGslSs..+..............................s...............tsthl.lsPo..Ghphsplp...s.scllhl.....c...h........c.G..phl.....................t.................t...pso............u-hshHttlapt.....ps.-spullHsHoshusuhu.h...................tp.l....s.....hstptst.h...........splsh.............h..hp.......G..tl....................u..pplspsht.......t...........................s.p...ulllpsH..GllshG......p.oltcAhhhhhhl....Epsschtl	............................................................................plhpsstths..phGh..s........p..hstGNl..Ss...p........................................t............psthl.I....pPo...Gh...t.ap...pls.......s..schl..hl...c...h........s.G.....chl....................................pt.......................thpPS......u-.hsh.HhtlYpt...............hs.ch.....tullHsHos..tusuhu.h.................................spsl...s...............hshptst..hhh......................sslsh..................h..h.hs........u.p..pcl..........................ups.ls..csht.........................................ptt..ulLlpsH....Ghhsh.G........c.s.hpcAht.hh.hlEpsAph..h......................................................	0	668	1344	1864
+1163	PF03752	ALF	DUF312; 	Short repeats of unknown function	Yeats C	anon	Yeats C	Repeat	This set of repeats is found in a small family of secreted proteins of no known function, though they are possibly involved in signal transduction. ALF stands for Alanine-rich (AL) - conserved Phenylalanine (F).	20.80	20.80	21.00	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.82	0.72	-4.10	42	301	2009-01-15 18:05:59	2003-04-07 12:59:11	8	24	42	0	140	347	0	41.90	30	20.81	CHANGED	Rsslsplhssu..GssVppAAptAL....sGsspslcsFLpsG.htAt	...............Rhtssplhssu....GssV+pAAptAL....sGo.spslcpFLpsG.h.A........	0	39	110	133
+1164	PF05208	ALG3		ALG3 protein	Wood V, Bateman A	anon	Pfam-B_3416 (release 7.7)	Family	The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man [3]. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.	21.50	21.50	21.70	22.00	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.58	0.70	-5.23	7	352	2012-10-03 03:08:05	2003-04-07 12:59:11	8	7	268	0	241	353	16	311.30	39	79.10	CHANGED	lsshLlLsEshlshllIp+VPYTEIDWtAYMpplpuhLs.GppDYopLpGsTGPLVYPAuaVYIYouLYaLTstGsslhhAQhlFAslYllsLulVhhlY.ppt+lPPalhsLhsho.hRlHSIaVLRLFNDshAhLhLahul......hhhcp+.......WthGuhhaSlAVuVKMNlLLasPAl.LlLhLtshu.hltTl.pLsshullQlllGlPFLhpaPspYLppuFDLGRhF.a+WTVNaRFlscclF.s+pFplsLLhhHLhLLlsFsps+Ws..t......+h..plls.lhptt......hchpht........p..sssphhos...............................................hhsuNhIGlhhuRSLHYQFYsWYaaoLPYLlWpss...hshhlthllhslhEasWNsYPSTstSS	.......................h...hlhhh-hhlsh.hll.pVsY.......TEIDWpsYMpp.lphhls.G...phDYsplc..GsTGPLVYPAGaVYlaphLY.alT...s.p........G................p.............s...lhhAQhlFuhlYlhsLhl..Vh.hhY....p...p.............tp.............l...PP.a...h....hh.hhs.ho.hRlHSIaVLRLFNDshAh.hhha.hul...............hh.h...p.pp...........................Wh..hushha.....Shu..VulKMNlLLahPul..hhlh.lh.t......hu..hhtsl.hl.h.l.h................shl....Q.llluhPFL...h.........p.p...P...h...........s........YlppuF-huR.FhacWTVNW+FlsEch...............Fhs+tFtlsLLh.hHlhhLhhFhhhpWh.........................p..t..t.h.ht..lh.p.........................................tst.hh...h........................................................................hhsuNhIGlhhuRSLHYQFasWahaslPaLLats....................hs..hh..lt.hhlhhh.EhsWNsaPSTshSS.....................................	0	90	136	201
+1165	PF03561	Allantoicase		Allantoicase repeat	Finn RD, Yeats C	anon	Yeats C	Family	This family is found in pairs in Allantoicases, forming the majority of the protein. These  proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction: allantoate + H(2)0 =  (-)-ureidoglycolate + urea.	21.60	21.60	30.60	23.80	19.10	20.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.10	0.71	-4.75	13	1158	2012-10-03 19:46:52	2003-04-07 12:59:11	10	13	467	6	534	1098	1048	143.30	39	75.20	CHANGED	GGpVlusSDpaFuss-NLlpPucsh..........chhDGWETRR+Rp................GH.DWslI+LGss.GhIcuh-lDTsaFpGNasstlSl-Ashhpsps..........................scsspWsplLstpcht...PcpcHhat...lsspp.aTHlRLsIaPDGGluRlRlaG	.......................................................................GutslssoDpaF.u.s.spsl.LtPstuh..........phhD..GWETRR+Rp.....................sGa..DWsll+Luts...G......h.....Ict.l-lDTuaFpGNaPstsSlpAshhss...s..s..............................................................................................................sps.ttWpp.lls.p.sp.Lp......ss...p...c..Hha........t..............l......s......s......t.....p.......s....h......THlRlsla.....P.DGGluRLRlaG..............................	0	146	279	433
+1166	PF04864	Alliinase_C		Allinase	Mifsud W	anon	Pfam-B_4527 (release 7.6)	Domain	Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase (EC:4.4.1.4), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.28	0.70	-5.80	10	180	2012-10-02 18:26:03	2003-04-07 12:59:11	8	7	33	19	77	718	304	318.40	46	79.58	CHANGED	sDlssGDPhFLEcYWp++t-soAVllSGWHRMSYF..tsss.pFlSsEL-+pI+cLHclVGNAsT--RaIVFGTGoTQLlpAslaALSPs..ssssusPspVVAssPYYusa+cQTsaFcuptY+WcGsAusah....cssssssaIELVTSPNNPDGtLRcuVl...cGopu..IaDhAYYWPHYTPITtsuDEDIMLFThSKhTGHuGSRFGWALVKDccVAcKhlcYlptNohGVS+EoQLRsLKILK.llssh+sppGo....clFpFGacph+pRWcpLsclVspSs.RFSLQch.ss-YCNYFp+h+sPSPuYAWlKCEh-c-pDCtphL+.su+IhTpuGshFtussRYVRLSlI+opDDFD.hlpRLsshl	...........................................................................................................................shspGDshhhE.aWh.p.ptttuslllssWppMSYh...ss...............Flp.EL-+pI+c.LH..c.hV.GN.A.s.s.cs.+.alVh.GsGsTQLhpuh..lhu.LSPs...........ssu..sp.VVu.t..sPa..Y...s.......s.a...p.......p..........Q......T........c.......a........h........c.........p........t........h........Y.......p........W.....s....G.......s.....A....s...s.a..........s.s...s..s..s.ppa...I.E......h....V..T..SPNNP.....-G......h......l......R.....c........u.....V...l........cG...s..p....u..........Ia.....D.....hs..Y.......Y........W..........P......H.....Y........T.....P........I....s......t.........t.......A........D.........c....D.......I.....M..L.F...T...hS.Kh.TGHuGS...............RhG.WAL....l.KD...c..pVh..p..+...hh...p.Yhp..h..NT..G.sS.....+-oQLRuhKlL...+...tVsshhc.......s.............p......p..st..........cl.pFGacphccRWhplp.sllspS..c.RFSlpch.ps......pYCsaFp+hpsssP................ua..AWlKCEhE..-...s.cDChphhp.sst.I.spsG...at......s.ssc.aVRlShlcpp-sFs.hhthLt.h........................................................................................................................................	0	14	57	67
+1167	PF04030	ALO		D-arabinono-1,4-lactone oxidase 	Wood V, Finn RD	anon	Pfam-B_33547 (release 7.3);	Family	This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.- , which is involved in the final step of the  D-erythroascorbic acid biosynthesis pathway [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.81	0.70	-4.80	34	1395	2012-10-02 00:48:38	2003-04-07 12:59:11	9	15	826	5	608	1305	206	200.00	21	43.75	CHANGED	lTlpslPuaslctppps.......hshppllcsh-phh..pps-ahchaWFPaocpshlhpsscssts...........sp.tpphhsphlsphhapsLhhlu.chhPslsPhlp+hshphhhu..........pptlssShcsFshsphh..p.h..EaulPhcpu.-sLpcLcshlspps.................hhlHaPlEVRhsssD......................................csaL..............SsshscsosYIssphYRshs.......hppaapthEslhpph.GGRPHWuKhaphsspp.............................lpphY.schccFhplRcchDPpshFls..sahc.+h	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................E.......a.......l..Ph.....p.......t....h.............t..............h..............l...p...pltthhptpt.........................h...hhs...l.phRhsts..s.......................................p...hL.................u..s.........t....p............s.....h.......hl.s.h...h..h.....t..s..t.................htp.hh..p....t.....h....-....p....h.........h....h.....c....a...u..G.......RP...HWu....K..........p..p..h..s.tpp...........................................................................................h..p...ph..Y....P...c.....h..pcFhtlRcc..h.DP..p..shFhs..sahcp.....................................................................................................	0	177	387	524
+1168	PF00128	Alpha-amylase	alpha-amylase; 	Alpha amylase, catalytic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Swissprot	Domain	Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the  active site, interrupted by a ~70 a.a. calcium-binding domain  protruding between beta strand 3 and alpha helix 3, and a  carboxyl-terminal Greek key beta-barrel domain.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.03	0.70	-5.03	31	28372	2012-10-03 05:44:19	2003-04-07 12:59:11	19	300	4623	473	6746	23482	3056	261.10	18	44.76	CHANGED	GDLpGIhpKL-..YLKc........LGlouIWloPlac.........Ss......u.HGYDhpDYpplsspaGTh-DhcpLlscsHp..+GlKlIlDhVsNHoSsppth...........Fpcuhpptss...hpcahh..h.h..........t.psssshht......h.stosaph......ppps.....h.hhhshsDLNhcNss.........lhpthhc....shcaWlcpG......lDGaRlDsspclsc............................sah+patpphsph.........thhhlGEhatss...sp.hhhhstsshhshs...hhsahphthtpssp.....hp.ss.s....htchpphlschhpthsp...sthtssalsNHDpsR.......hhothusst................ph+hshshlhshp.GsPhIYhGpEhGhoGsp.........DP	...............................................................................................................l.s....al.t.p........lGh.....stl.......l.....P..hhp......................................ss...........ts.h.G..Y..s........s..........h.......s.......a............h.........s.........l.........s.........s.........p.........a..............G..............s.........................p...........-...........h........c...........p...........h....l....pth.+p..........tG.......l...............p...l.l......hDh......Vh....N......H.h...u......t...p...p........h...................................................................................t........t.................t...h.......................................................................................................................h..t..............................................................................p.l..s....h....t....p............................................................hh.p...h..........h...p.......ht.a.h.h.p...h..................lc.Gh...R.....h.Dhh.t..h..h...........................................................................................................h..h.t....h...h..t....h.t...t.......................................h.hhh.u.E...h......t.............................................................................................................t.........................................t.....................................................................................................................h...........................................................................................................h.......t....s..H.D.................................................................................................................................................h.......h...h.......t.................................h...........................................................................................................................................................................................................................................	1	2088	4020	5641
+1169	PF02903	Alpha-amylase_N	alpha-amylase_N; 	Alpha amylase, N-terminal ig-like domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.20	21.20	21.50	21.30	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.77	0.71	-4.14	38	1507	2009-09-11 01:10:01	2003-04-07 12:59:11	9	20	1336	56	147	988	29	118.10	30	20.02	CHANGED	Mh.htAIaH+PpssaAYsYsppplHIRLRTcKsDlp.cVtLlauDsYph..................th.hpphsMcKhuos...plaDYW.splsssh+.R..l+YsFpLps.sscphhas-cG...hapctshs...hthaFpaPalp	......................................shaHhP.s...as...h...h...h...s...c...c.....p...LpIpLps.....p.p.p.D.l.s....c......lh.L.hhtcshp................................tshs...McKht..S.s..........sh..a..-..a..W....p..ssl..s..h..s...t..R...hpYsFcLhs..c....scphaas.spG.............hs...p..h.s.hc.................................................	1	45	79	112
+1170	PF02296	Alpha_adaptin_C		Alpha adaptin AP2, C-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_8859 (release 5.2)	Family	Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.	24.20	24.20	24.30	24.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.39	0.71	-4.12	21	349	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	230	11	231	333	4	109.80	43	12.10	CHANGED	FhcPspl.oupDFFpRWKQluusspEAQ+IFt..........uspshstshs+phl.pGFthulLpsVDPNscNhVuAullpop.uGp...lGCLLRLEPN.hpspMaRLTlRuoc-sVsptLhcl	..................FhpPsch.su.p-FFpRWKQLu.....ss...t..p.E..sQcIFp.............us+sh-....tp..h.s+s.tl....hGFuhslL...cs.V..DPNPp...N...hV.G.AGllpT...c......ssp........lGCLLRLEP....N...hpupMaRLTlRooc-.sVsptLsc...............	0	80	124	184
+1171	PF02883	Alpha_adaptinC2		Adaptin C-terminal domain	Bateman A, Griffiths-Jones SR, Mian N	anon	Pfam-B_8859 (release 5.2)	Domain	Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.  This ig-fold domain is found in alpha, beta and gamma adaptins.	20.60	20.60	20.60	20.90	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.62	0.71	-3.77	102	1431	2012-10-03 16:25:20	2003-04-07 12:59:11	15	26	301	45	862	1378	12	109.40	19	13.69	CHANGED	ssshlapssslplthphph..........tpsshhplphhhsN...p.sspslsshshp..hulP.........pshplplpss.sssslss.......ssplpQhlhlts...........hph+l+lsaphs...up.th...p.t.h...hP	.....................................hhlapps.slp.lthphph............tpsshhhlhlphsN.......p..sspslsshshQ....hs..ss.............................cshplp.Lpss...sssplss..........ssplpQhhhlt.s.......................t...p..hplclsap.hs.st.......p.h........................................	1	253	405	648
+1172	PF00944	Peptidase_S3	Alpha_core; 	Alphavirus core protein 	Finn RD, Bateman A	anon	Pfam-B_266 (release 3.0)	Domain	Also known as coat protein C and capsid protein C. This makes the literature very confusing.  Alphaviruses consist of a nucleoprotein core, a lipid membrane which envelopes the core, and glycoprotein spikes protruding from the lipid membrane.	20.70	20.70	20.80	20.80	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.86	0.71	-4.81	5	862	2012-10-02 13:45:52	2003-04-07 12:59:11	14	3	54	46	0	511	4	104.80	71	12.60	CHANGED	sMKLEuD+TFPlhL.DGKVNGYAClVGGKVhKPLHVKGTIDNPsLAKLKFKKSSpYDLEaAcVPssMKSDAFpYToEKPEGFYNWHHGAVQYSNGRFTVP+GVGGKGDSGRPILDNoGKVVAIVLGGANEGuRTALSVVTWNcKGVTlKTTPEuoEpWS	...............................................................................................................GRFoVP+GVGuKGDSGRPILDNKGRVVAIVLGGsNEGSRTALSVVTWNpKGVTlKhTPEGoE.WS..........	0	0	0	0
+1173	PF01589	Alpha_E1_glycop		Alphavirus E1 glycoprotein	Bateman A	anon	Pfam-B_587 (release 4.1)	Family	E1 forms a heterodimer with E2 Pfam:PF00943.  The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus) [2].	25.00	25.00	25.30	27.00	18.20	24.60	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-12.88	0.70	-6.18	17	1920	2012-10-01 19:42:26	2003-04-07 12:59:11	11	5	59	57	0	941	0	247.60	48	50.15	CHANGED	.tu+Ats.hsEohsYLWspNQshFWhQhshPlAulllls.hlRsh.CCh...sFLllhu........ls.ssspAYEHssslPNhVGhP.YKAlV-RsGYuPLsLplpVlpopL.PolsLEYITCcYKTVVPSPhVKCCGssECss..........ppcsDYpC+VaTGVYPFMWGGAYCFCDoENTQhSEAYV-+S-sCptD..HAtAY+sHTASLKApl+loYGsss.psl-saVNG-ossphsshKhIhGPlSoAWoPFDsKlVVYKs-VYNhDFP.YGuGpPGpFGDIQuRTss...SsDLYANTsL+LtRPuuGslHVPYTQsPSGFchWhp-+GpsLspsAPFGCpIpsNPlRA.NCAVGsIPlSlDIPDAAFTRls-uPslopLpCpVssCTaSoDFGGlAslpYpo-+sGcCuVHSHSssAsLpEuslcVhp........sGphTlHFSTASspssFhVplCus+sTCpAcCcPPKDHIVsaPspHssthhsslSsTAhoWlptlhGGsusllslullllllVshlshpR	..........................................................................................................................................................................................................FMWG.................................................tt.s...h.sasNG.pssp.tt.phhhGPhSouaoPFDp..........................................................................................................................................................................................................................................................................................	0	0	0	0
+1174	PF00943	Alpha_E2_glycop		Alphavirus E2 glycoprotein	Finn RD, Bateman A	anon	Pfam-B_308 (release 3.0)	Family	E2 forms a heterodimer with E1.  The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus) [3].	19.50	19.50	21.10	21.00	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.51	0.70	-5.84	23	2166	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	59	31	0	967	0	320.80	49	61.18	CHANGED	PYlAhCscCutGtsCaSPlAIEpVpu-AsDGhl+IQsSuQhGls.puGstctsKhRYhts...pclcEushsslpVpTSuPCpllushGaFlLA+CPPGDolTVuFp.sssss+uCplsa+hc.p.VGRE+ashsPpHGp-lP.....CssYspssppost..l-MH..hPsshsDpoLLSpsuGsVpls.PuG+slpYcCpC.GstpsGTs.oocpplssCsts.QC+AahsspsKW.aNSshlPR.usspshKGKlHVPFsLssuTCpVPLA.pPsVpauh+ploL+LHPc+PTLLThRpLGs-PphocEWIotsssRshsVsccGlEYsWGNpsPlRlWAQ.cousGsPHGaPHEIlpaYYphYPssTlsslsusuhllhluluuSshhhspARpcCLTPYsLTPsAtlP......hsLulLCC	.......PYlu+CssCtcu.sCaSPltIEcVhs-ucDGhlRIQTSu.aG.D.posptctp+hRYMss...hpltEu.hcplpVpTSuPCpllshpGYFlLs+CPPGDolTVuhh.pssshHSCTVth+Vphp.VGREpYpaPP.HGtplP.....CssYsphppsousY.lpMH..h.Gshs.oThLppppGpVhlssPuGpTVpY-CpC.uspp.GTT..upchplhhCccscQChAYlsspsKWVaNSscL.R.u.sscohKGKlHlPFsLssssChVshA.tPhVp.hh+tlhL+LpscpPTLLohRpLGt-sp.ptcWlpt.sphshoVstEGlEasWGN.sPhRhWuQ..os.GsPHGaPHEll.aYYphaPhhTlhslsshshhhhlshssohhhhspsRp.ClTPYtLsPsApVP......hhlulhCC.....	0	0	0	0
+1175	PF01563	Alpha_E3_glycop		Alphavirus E3 glycoprotein	Bateman A	anon	Pfam-B_285 (release 4.0)	Family	This protein is found in some alphaviruses as a virion associated spike protein [1].	25.00	25.00	67.70	67.70	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.83	0.72	-4.16	25	939	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	57	13	0	592	0	56.50	63	6.95	CHANGED	MClLANlTFPCspP...PsCY-+pPppTLchLEsNVDpPGY.pLLcAsl+Css..pRp+R	.MClLANlTFPCsQP...PlCYsRpPcpsLshLE-NsDsPuYDELLpusV+Csu..+RtKR....	0	0	0	0
+1176	PF03229	Alpha_GJ		Alphavirus glycoprotein J	Bateman A	anon	Pfam-B_3350 (release 6.5)	Family	\N	21.00	21.00	21.00	21.30	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.96	0.71	-3.79	5	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	8	0	3	47	0	92.70	53	76.17	CHANGED	MRSLLFVVGAWVAAlVTsLoPcAALATGsTsTsGsANu....sssssAoGANATSAsAuuThAAssssPPscST.sstTPGPaPPTDFALPLVIGGLCALTLAAMGAGALLHRCCRR.AARRRQRVSYVYA	...........................hu.ls...........................................................uslAATphuPAuso....TpAPsoPaPSPhus...FAl....PLVlGGLCAlVLuAhshhtLLRRsCRt.huR...........hs............	0	0	0	3
+1177	PF01120	Alpha_L_fucos		Alpha-L-fucosidase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.20	0.70	-5.55	48	2021	2012-10-03 05:44:19	2003-04-07 12:59:11	12	80	870	58	664	1863	422	324.50	24	62.37	CHANGED	hlllh.........hhhts...........spspapPsh-sls............ppt.pWFc-sKFGlFlHWGlYSVPuhs.....................sEW.......................hhpp..pthsstpYt........chs..........spFssp......pFDscpWsphhKpuGAKYhlhToKHH-GFshWcS.....chot.aNssc......ssPKRDlltELspAs+cp.Gl+hGh..YaS..hh.-Waps.a.htcppstht................phppa.............................................hp.hhhsQlpELlspY.ps-llWhDGsWtt.............................ssptWpt...schhshlhphpP...slllssRhtpss.tth..........sapss.EpthPsp..........l.ppsWEsChTl.ssoWGY...phpspsapospplIcpLlcsVSpGGNLLLNlGPps-GslsshtpcpLpphGpWhchNGEuIYu	.............................................................................hhhh.h.............................................................ap....p.....chGhhhHaG..sh..s.............................pW.......................................t.................ta.t...................................p...........p.tF.s..s..p........paDs..cpWschh+puGhKalllTsKHH..D.GFs....La..s..o..........p.ho.......s...asshs..........pss...+...p...Dllt..ElspAs+c.......t..GlchGl....YhS.......h...D.......h....p..p....s......a....hh..st.pt.........................................h...........................................................hp.hhhsQlpE.Ll...s.......p....Y...sp...h.s....hlWhDGs.hst.................................................stpth.ph..........pchh.phl..c.p.h.pP....................ssll......s......s......+hss.s......h....................................th.p..-..p........s.t.t...................................h...h..a......E..s..sh...o.....l....p.......suWhY.......................tpspph..K..ohppllc.h.hh...c.sVu.+s....us.l.LLNls.Pst.sGhlsstthptLtphGp.aht..............................................................................................................................................................	0	276	488	583
+1178	PF02232	Alpha_TIF		Alpha trans-inducing protein (Alpha-TIF) 	Bateman A, Mian N	anon	Pfam-B_1799 (release 5.2)	Family	Alpha-TIF, a virion protein (VP16), is involved in transcriptional activation of viral immediate early (IE) promoters (alpha genes). Specificity of Swiss:P23990 for IE genes is conferred by the  400 residue N-terminal, the 80 residue C-terminal is responsible for transcriptional activation [1].	25.00	25.00	191.50	191.30	18.40	17.60	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.14	0.70	-5.63	13	66	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	37	1	0	62	0	333.00	47	75.87	CHANGED	sssss+luhPP....PpsuuPssLYpRLlpELsFsEGPuLLutLEphNEDLFSClPtNtDLYpcstlLSssss-Vlcsspsssst....ssslsLssHGstshPpsPusc--LPsYVpulQpFFhuELRAREcsYs+LLhsYC+ALlcYL+usup+shRGht.ps.pstthpp+hRphltsRYYREsA+LARLLYLHLYLoloRElSWRLaApQstpQsVFsuL+acWtQtRQFpCLFpPlLFNHGlVhLEGcPLsutcLRclNYhRccLGLPLlRsuLlEEpsuPLsp.PsFoushPRosGaLsppIRuKh-uYSpt+sssPt.pspp-HsYu+thsss.NYGoTlEAhL.cPssP	.......s.pttphh.sP....PhsssPsuLapRLlc-LsFs-GPuLLotLEpWNEDLFSslPtNtDLYp-sthLSssss-Vlptsps.sst....tstlDLpsHGshshPpsPusc-sLPsYVpulpcFFhuELRAREEuYsplLssYC+ALh+YL+uou+cthRththps.pstshtcphRphIusRYYREsARLARlLaLHLYLsloRElSWRLaApQhhppslFssLph-WpptRQhsCLFpPllFNHGlVhlcGtPlpAtcLRclNYhRccLGLPLlRsuLlEEssuPLsp.PsFpushPRuuGaLhphIRuKh-uYSphtsspPp.tshpEHsYu+thsts.NYGSTlEuhL.sPss.s....................	0	0	0	0
+1179	PF02430	AMA-1		Apical membrane antigen 1	Mian N, Bateman A	anon	Pfam-B_2016 (release 5.4)	Family	Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites [1].	20.10	20.10	38.70	21.90	17.70	18.30	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.96	0.70	-5.61	7	1565	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	33	38	37	1845	0	343.80	69	86.34	CHANGED	WpcaMtKaDIt+sHGSGIhVDLGEDApVtspsYRhPsGKCPVhGKuIhlpNus.sF.LoPluotstpl+ptGLAFPp.......................s-splSPlThssL+ph.YKcp......sDlu.CucaAushVPusspNopYRaPhVYDcpschCYlLYsuhQ.N.GsRYCssD..tsp.csuhhChpPtKscp.ppLsYhopslcpDW-psCPh+sl+sAhFGhWsD..GpC.sht.hhpcpucsh.-CspIlFptSASD.p.cphpcchsDhpclppGhpptNhphltpA.FhPluuhpucphKS+GhGhNWANYDscspKChIhsspPoCLI.spsalAhTALSSP.E.sthsaPCsIhKschhh.............................E.+tpspsht.ss.s........hP.clahS.cK-oLcCss.spphssuoCs.aalCssVEtct.lppsp.l.l...............hsp+phllIhlhhssuslllslhhhaha+.......+pcsu-.............cYD+ht	...............................................................+CPVFGKGIII....E....N.......S......s...TTF.LTPV..ATtsQcLK....D...GGFAFPP.........................TpPhh..SPMTLssM.Rc.h...YKDNc.V.....KNLDELTLCSRHA...GN...M.sP....DsD.......c...NSN...YK.YPAVYD-K-KKCHILYIAAQENNGP.RYCNKD..pSK..RNSMFCFRPAKD.cS.F.p.NYTYLSKNVV...c....N....WE...KsCP.RKNLpNAKFGL..WVD..GNCE-.I.Pa...Vp.E...h...pApDLhECN+lVF..ph..S..ASD.QPpQYEpchTDYpKIppGF+ppNtpMIKSA.FLPsGAFpuDpaKS+G+GaNWuNa..sp.....p..pKC.IFNsKPTCLINspsaIATTALSHP.E.V-.pFPCSlYKsEI.+.............................EIc+pS+php.L.ssDs...c+IlhP.RIFISsDh-SlKCPCtPEhlSNSTCp.FaVCpCVE+RAElppNNpVVl................p...........................................................................................................................................................................	0	13	17	33
+1180	PF03913	Amb_V_allergen		Amb V Allergen	Finn RD	anon	DOMO:DM04509;	Family	\N	25.00	25.00	66.90	66.60	21.60	20.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.72	0.72	-4.23	3	4	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	3	3	0	8	0	42.80	61	62.87	CHANGED	lssCYhAGolCGEKRuYCCSDPGRYCPWQVVCYES+cICuKNCu	..hsChhAGslCGEKRuYCCSDPGRYCPWQVVCYESpcICuKpCu	0	0	0	0
+1181	PF02948	Amelogenin		Amelogenin	Bateman A	anon	Pfam-B_402 (release 6.4)	Family	Amelogenins play a role in biomineralisation. They seem to regulate the  formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta [1].	21.00	21.00	21.00	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.51	0.71	-3.64	6	451	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	281	0	28	407	0	113.20	52	97.18	CHANGED	lPLPPHPpHPGYVNFSYE..............VLTPLKWYQShhpHQYPsYGYEPhGGWL+p.hlP.hsPQhPpQp....phhPpLsPHHplhhl.......PQpPhh.hPuHHPhhPh.tp...pPph......PsQcPlpPpssp.P....QPQQPspopPPhp.p.PhsPpss..........pPMaPlQPLPPhlPDhPLEPW.uADKTKQEElD	..........................................................................h+p..phhP..h........s.pa............hh.shHph..............P..Q.pPh.h.....PG..pps...hsPhptp....ps....hs.....PsQpPh.Q...Ppssp...P.........QPpQP.lp...P...p.Ph...HPhQPhsPp................P.haPhQ...PLPPhlPDhPLEuWP....................................	1	2	2	6
+1182	PF04709	AMH_N		Anti-Mullerian hormone, N terminal region	Kerrison ND	anon	DOMO:DM04835;	Family	Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation [1].  Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism [2]. This family represents the N terminal part of the protein, which is not thought to be essential for activity [2].\	 AMH contains a TGF-beta domain (Pfam:PF00019), at the C terminus.	19.60	19.60	20.10	20.00	19.40	17.50	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.36	0.70	-5.51	13	109	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	66	0	28	87	0	261.20	30	66.38	CHANGED	lpch.sAFlEul.pcuchsppDLspFGlCssuDssushs.Lp.Luphlscsttp..tLhVLHhpEVhW.......EsslpLpFphP...hsu..uss.s....sLLlhasGshts....ss.cVohousuL.PtsQSlClScDTpYLlLsscts..........puuhpsphhshs.p+ps-.GspLshs-LpthLhGscs+shTphTPlLLh............sus.hsucGplcssPhPps...........sPssT...............sFLspLpRFlRslLsP..pupsss.u.....LshsuLpoLPph.LsLSsotu.LtpLlsSppPolhlF.......sshsusLps.ppuphshpsuLlpcLtt+Lppstscl....Rshsuhsssss.hLpRLhsLssh....ssssuuuss....phRALLLLKALQoVpspWctcR	............................pth.tshhpsl..putht.ps.thFGhCss..tttsh...hp..ltt.ht....t..th.shH.tt.s.hh.......p....Lhhp.s....................hhLhh..s.........st.tl..htt..l....ttQslC.otsTpalhLsst.s..........tut....h...h..s.t...psp...tt..................h........ph...Lhstt.ts.hphpPhLLh................................ssph.hphhs.hs...................................ss.ps..........................FLppLpthlttlhs.......ptt............l..t.htshP...lshSpsts.Lttllpupt..lh.h........t..........s.ht...slhp.lh.cLptshhph....pt..s...sh...hht+Lhths............t...tssts..........hpuhLLLKALQslhttap.p.................................	2	1	3	9
+1183	PF01425	Amidase		Amidase	Bateman A	anon	Pfam-B_191 (release 2.1)	Family	\N	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.52	0.70	-5.63	44	12240	2009-01-15 18:05:59	2003-04-07 12:59:11	16	79	4062	116	4833	11144	9300	393.40	26	83.65	CHANGED	-llcthls+hpthppplsshhphhhppAhptApphcppht.......tssLtGlPlulKDslslp.GhsoTsGothhp..shhssh..DuslVcpL+puGAlllGKTNhsEhuhussspssha.........GsspNPashsc...ssGGSSGGuAAsVAushsshulGoDsGGSIRhPAuhCGlsGhK......PThGRluptGlh.....shssohDpsGshu+sVcDsulhhpsltGt-.tDssshs.............htt.httt.ptl+lGlhpp.h.......................................h.shsstlpcshppshttLpphG.tplhchphs.ht.hhs.hhhhhhssps.t......................h.chhsphp..s..phhsstlptpl.hsshshsth......hhpspph+t.hhpcphtphapp...............lDlllsPosstsshphsth..............t.sthhth.shs..ssssshsGhPulo......lPsuhs.pp.................GLPlGlQlhupthp-ptlL	.................................................................................................................hhpthhtph...t.....t...h......p............t.........l.p...s.....h...h..t........h....................p.....t...A..h.t...t....A.......p..t.h......-.......t..............t...........h...................................t.............t.........................................s.............s......L.t......GlP.lulKD...h.....s...s...............t.....G.....h..To.s.G..o......t...h.h..t.................s..h.....h...s.........s.h...........D...A....s..l..........V..pp.L........p....p........u........G............ul................h.l...........GKT.NhsEa.....u....h.....u..s.....s.....s..p...s..s..h..a....................................G.....s.p...N...P......a...........s.........h............s.......t....................ssG.G..SSu..Go..AA......A..V...............A..u.....s.............h..............s............s.h.....ulGoD...s.G..............G..S.....lR....PA.u...hsGl.........sG.hK.........Po......h..G......t..l....s....p...h...Ghh..................sh.s.s.s...h..-.....p.....h..G..P...hs..+...o......l...p...Dsu.hl...h.........p...s.l.............s.......u.......-.....s......t.....c.s.t..sh....................................h...........t................h.........t.....t.......s.........h..........p.........s...........h....+...l...u.l...p.p.hh................................................h....t..h...s...s...p...l.t...t.s..h.pp...s..h.p..h...L...p.p...h......G....t....p.............l........p.........h.....s.....h.......s..........h...p...........s......h.....t......hh...h.h....h..h.......s..-..st.t.t....................................................................h..p.h..h..h..t..t..p....s.........p.t...h....s..........t....h........p.......t....t...h.....h........h..u..t.....h..h...h.....s..s...t........................................h...hpu...t..ph...cp......hh...t..p..p..h.t.p..hhpp........................................h.D..hl..ls.Ps.s.s..t....s..s...th..s..t.....................................s.h...h....h...h.................h....h......s.......................h......h...s..h..s.......G...h.Pu.lo..............lP.s....uhs....p................................................................................Gh.P.l.G.lQlhu.t.hhp-ttl.............................................................................................................................................................................................................................................................................................	0	1337	2800	4004
+1184	PF01832	Glucosaminidase	Amidase_4; 	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	Bateman A	anon	Pfam-B_888 (release 4.0)	Family	This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J Swiss:P75942 that has been shown to hydrolyse peptidoglycan [1].	21.70	21.70	21.70	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.93	0.71	-4.05	162	6435	2012-10-03 00:09:25	2003-04-07 12:59:11	15	195	2899	3	744	3961	1635	133.40	25	32.41	CHANGED	htstApphtpc.hsl.s.slhlA..QAhLESuW......GpSt.....huppsp.NLFGIKut..........tst...htht.....TtEh.p.sth.phpspFRsYsohp-Shp-asp.hlpssst......Y...p..sshp..t..tpshpth....sptlpts.G....YA....T......D.PsYupKlhsll...pp.hsL	...............................h....h.phtpc.hs...l..s.shhlA..QAhLESua...........GpSp...........................hup.p.sp...NlFGlKu......................h.h...........................t.ch.s..spt.h.shtspa...+...t......a....sS.....hp.-u.lp.sasp..hlpps.t...................Y.........p..shhp....t.........ttshpps..........sttlppt.t...........YA.....T.................D..spYupc.lhsllppht............................................................................	0	222	434	613
+1185	PF02274	Amidinotransf		Amidinotransferase	Mian N, Bateman A	anon	Pfam-B_5784 (release 5.2) and Pfam-B_1850 (release 5.5)	Family	This family contains glycine (EC:2.1.4.1) and inosamine  (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively.  This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyse the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumour glycoprotein  [4] (Swiss:P16962).	22.00	22.00	22.00	22.00	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.74	0.70	-5.32	55	3546	2012-10-01 20:45:11	2003-04-07 12:59:11	12	9	2331	60	857	2617	1976	321.90	24	89.76	CHANGED	hhR.PsphthN.spostsshh.............sst.h.ppAhpEacshlptL+pp.GlcVhhlcch.t..................................................................................sshP-ulFspshhus....ts..uslslhPMhs.sRRpEpphshhhhhpp.....hth..hhchs.thc.psthLEG.Gshlhspppplshusts.Rosppslcphspphshp..shhhps...hssptpshhHhsshhslusphsllshsslhsst............................cphlhpt.......Lptss.hcl.Iplu.......tcphh.shuuNhLpl.....s......h..s.hAass.s.sppphhcp............tscllthslsplp.tGGGusRCMhstlah	......................................................................................................................................................hpPt..h.phh.s.hpphh...................ssh..lptA.p.c.EH-taspsL......+pp...G...l..c..Vhhlc.s.l.h.t.............................................................................................s.shPsh....h..F....sRDstsh..............ls....ss...l....slspM......h.t..sRppE....shhhp...hl...hphp.................................th.hhh...shp...t................ss............plEG.GDhlh..l...u...c.............s..h.....l.s.......h........G..........h........u.........p...R.Tst.pul-...............pl...sp..plhpp........h....p.......l............l...s.h.....th...s......p.......s...c......s........h............hHLDT..sh.o.hl..........-........h......c......p.........hs.h.a.s.t.lh.st...............................................hph.ltpt...................L.t...h...c..p...hpl...Ipsu...................................tcEta....s...u..sNsLsl................ssGsV...................................lsas..p..s.s..h....s..s.p..h.L.c..ct..............................................Gl..c..l..lt....ls......ss.ELs..+GtG...Gs+CMohsl.R..............................................................................................	0	307	557	719
+1186	PF01979	Amidohydro_1	Adenine_deam;	Amidohydrolase family	Bateman A	anon	Bateman A	Domain	This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate +  H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5]. 	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.00	0.70	-4.79	58	18418	2012-10-03 00:45:34	2003-04-07 12:59:11	15	103	4730	152	4606	25313	10133	289.10	14	66.61	CHANGED	hlhPGhI...DsHlHhhps..t..................................h.shtpshpphlpuGsTsstsh...tssss................................htchlts..s.ph...hthh..spsuhts.htphhhsts.......................................lchhpshtth.....thhsshstpsstthtpsthtstsphscc.....t.slhhshHhtpssss.....................................h..h.....................hh.h......sthphhhhshhls....p..th.......tsstlshpshusct............t...t...lspshhphhphhpp.tht....ht.t...s....................................hsstchlphsThssAcshGl.pphGslpsGchADlllhc	...............................................................................................................................................................................................................................................................................................................................................................................lhPGhl......Ds..H...h.H..h...h...t.s....h.......................................................................................................................................................t...s......h....t.........h...h....p..t...h...h.....t....s.G...s.....T.s....h.h.s.h......ts.............................................................................................................h...p.....h.h....t........t...t........................................h...................................h.....s...........h.........h.....................................................................................................................h.c.....h.h.p....t.h....t....t...h......................................................t....h.....h............s......h......s...........p.............s.........s......t..........s..........h.........h..........p.........s..........t..........h.........h......s................t......h......t.......h....s.......p......t...............................................t..............t....h......h....h...p.....h...c...h...t..p...s...t..tt..........................................................................................h..h.............................................................................................t...hhh...h................................t....t....h.....t.....h......h.h....h...s..h...hlp.........................p.........ph...t.h..........h................t.......t...........t......s..t......h...t......t...t.............h........s...........s.....t....p........................................................................................................................................................................h........t......p....s.....h.....h..........h....h....p.......h...h.p...t.........th..............................................................................................................................................................................................................hsht..p..h...l.t..h...s....o.h....s.s....A....p.......h...h......s.........h....................t.........p........h.......G......p....l.tsG.t.ADhllh.......................................................................................................................................................................................................................................................................	0	1418	2812	3769
+1187	PF04909	Amidohydro_2		Amidohydrolase	Bateman A	anon	Pfam-B_4687 (release 7.6)	Domain	These proteins are amidohydrolases that are related to Pfam:PF01979 [1].	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.72	0.70	-4.84	132	6287	2012-10-03 00:45:34	2003-04-07 12:59:11	9	30	2257	66	2486	6470	2429	284.10	13	85.76	CHANGED	lDsHtH...................................................................t.th...h.hthtsh..thh.hts.hsh.tts....shh....ttt.s..shspt............h..h.....tthh.p..t.s..sthhshsshs........t..p......shtphtcth......................................................tphshtG....................lp..ht..thtss...stth..............................................hhp..........thtch.s.l.....slt.la......................................................................hthtp.hhht.slh....ccaPp.......lplllsHhGhs..................htth..hthhtptsslah...chst...h........................h.ssh.t.....h.....htph...hphhs.s...-+llaGoD.....................aPhhsh.tts.hsthh.th.h.......................stptpcplhtsNAt+lath	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..................h.....................h.......t..h....s....p..............................h..h.......t..hh..t.......t...s.........s..t.h..h..s.h...s......s......h......s.....................t......t...................sh..tc.h.t..c....th..................................................................................t....p..h....u.....h.p..G...........................lp........l...........s.....t..h.......t.....s..h............t...s..tthh...............................................s.hhp..................................t.htc.h......s...h...........s.lh.lH.................................s......................................................................................................h.t.t..t..t....h..h...h..t...slh.........pc..a.Pp........lpl..l.......l....sHhGts....................................................ht.th..h..t.......h...h...t.....p.....h.....s.....s..l..a.h......c.hut..h....................................................................shh...h...t.....h...............h.t..th......h.p..t..h.u.............-.+...l.l....aGSD..........................................a.P...h....s..p.......h....tt....httht...th.h................................................stpt...tp..plhhpNAtclat........................................................................................................................................	0	680	1536	2082
+1188	PF00155	Aminotran_1_2	aminotran_1; aminotran_1_2; 	Aminotransferase class I and II	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.94	0.70	-5.51	48	52439	2012-10-02 18:26:03	2003-04-07 12:59:11	16	160	5588	558	14604	63947	26038	337.30	17	82.76	CHANGED	sphlsLussphths.....hhtshhcst.c..........htttpshptYhshpuhsphcptlA.....chht........t.......h..ptp.slhhsuGssushtshhhhh......h.suct.lllssPsassatpshchsssp.lhhhth.............pshplDhpslppslpp...............phllhssspNPsGsshshcplpplhphsppp.shhllsDEsYtshshut...t..s....................hhhlpst.p......hhlstohSKsh.GlsG.RlGhlhu.ss...................pllstlpphspshhs...sststthssshLsssthh........plpphtpcltpp+phlhstLtph.....shshhtsp.uuhashhshsst.................th.ph........................Lhpc.hslhlhshp..th........s.hhRlsh.sshospplcthhptl	..............................................................................................................................................................................t.................................................h.h.tt.h...........................................t..t...s...h...h...h...Y........s.....s.........t.....u........h............t.......L......c...p....s...l..u...........phht......................................................h.......h....p...s.p..........p..l...h...h.....s...s...G.....s..p......t....s.....l..t.....h....h....h....t...h..h.............................h..t....s.......u......-........t........l.....l.....l....s.......s......P.......s.....a.............s.......s......h..........h.....t...........s.........h............p.....h.......s.........u............s...........p..........h...........h....t...h..s....h.........................................t...h....t......h....c......h....p...t......l....p....p....t....l....p..p..................................................................p..h.l.......l.....l.s....s...s....p....N...P........o.............G........s.....s...........h....s.....h....p.......p....h..p...p....l......h....p.......h...........s.........p.........c.............h......s..........h..............h...........l..l................D......-....s...Y...s....p...h..s....h..s.tt......t..s.....................................................htt.h..s..t.t..p..................h.lh.h.s...o...h.......S......K.s......h...........u........h..........s....G.h...R..l......G...a..h..s...u...st.................................................pl.h...p.......t....l.......p.......p.....h....t.....p.......h....hh...............ss.h..s...t...h....s.......s....h..s...s.....l...p....s...s..t.......................................th.p.p..h..p....p.....t......h....t....p....p....p....p...h...h.......h..p...t....L.pph..........................................sh..p..h...h.....t....s......p......u.......u........h....h....h...h..h..t..h..s.tt.............................................................t.s...p..h..h..pt.......................................L..h.....p.....c...........s.....l.....h.......l...h..s..s....t....h.sh...............................tt..h.lR.lsh..........h.h...s...p...p.h.pthht...........................................................................................................................................................................................................................................	0	4349	8681	12025
+1189	PF00202	Aminotran_3	aminotran_3; 	Aminotransferase class-III	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.97	0.70	-5.59	18	23135	2012-10-02 18:26:03	2003-04-07 12:59:11	16	134	4515	255	6601	18830	12804	322.10	28	72.23	CHANGED	sls+ucGsalh.Dh-GpcYlDhhSuhussshGHsHPcllpAlppQtsplsass.tshspcshhpluccLsphh....st.sh-+lhhssoGoEAsEsAlKhA+...h....shsp+s....................cIluFpsuaHGRThuulSl.ssssth+phhtPhhssh........hhlPaschts...............t.......h..hhpphpsssl..AAlIlEP.lQGEGGhhhsssuaLptl+clCccaslLlIhDEVQTGhGRTGchFAt-a..hGlsP...Dlhshu.KuluGG.hPluAslsssclhpsh..psss.......HGsTasGNPlAsAluhusLcllpc-pllpsspchushLpptLp.pLpct..shltclRGt..GhhhulEhsc	.........................................................................................................................................h..t+ucG.shlh....D.h.-...G......p....c.....Y...l..Dh.h.u..u.h.u................s.h.s.h.G.H..s....+...P...p.l....s...p.....A..l.p....c.........Q..h....p........p..h..h..p..h....................s.h...........s...........s.......p...s......t....h....c..LA....cpLsphs.....................................sh....c.....c....l....h..h.s..s..S....G...oEA....sEsAlKlAR.......................................s......h...s...t.....+s.................................................................................p.l.l.sh..p.s.u.aHG....co...h.......u....s...l.......u........h.......s......s.......t.....s......s.......h.......p.......p.......h......h......t...s.....h...h..s..s.h..............................ht..s..s..hs.s..hht.....................................................................................................t..............h..h......t......h......t.......s....p...p...l.........AA..l.ll.EP..l.Q..G.......p..u.......G..h..h.....s....s..s.....s..aLp.........tl.......Rc.......l.................C...c................c..............a................s....hL.................L.....................IhDE...V.t....o......G..h....G...R....T....G.........p.....h.....a..........A..........h............p...p..................h...u.....l......p...P.................D....l...h....s..h...u...K.u.l........u..G.G...hP.lu.A.h.l..s..p....p........c..l..h..p..s...h....t.sss........................au.s.Ta..u.G...N....Pl.A..s.A....s...u...h..A...s...L.c..l.....l.........p....p........p......s.....l..h....p...p.......s.p......p....h.u....p....h....l...t.....p....t.....Lp.....pl.....t..p..........p.................s.......h.......l..t..c...l....R..uh......G..hhhulph..p...................................................................	0	1940	3976	5469
+1190	PF01063	Aminotran_4	AA_transferase_C4;aminotran_4; 	Aminotransferase class IV	Finn RD, Bateman A	anon	Pfam-B_607 (release 3.0)	Domain	The D-amino acid transferases (D-AAT) are required by bacteria to  catalyse the synthesis of D-glutamic acid and D-alanine, which are  essential constituents of bacterial cell wall and are the building block for other D-amino acids.  Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.	20.50	20.50	20.50	20.80	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.44	0.70	-4.89	78	10610	2009-01-15 18:05:59	2003-04-07 12:59:11	14	29	4578	127	2921	7879	6007	228.80	22	69.44	CHANGED	hhlcpHhpRLtposptl...........thshshpp..........lpphlpphl........cths...tpss.hl+lh..lsps.t.h........................thhhhtttts.phhhspphphs.tsh........................hsphKosshhtthh.ttctt.....t....uh-c..s.lhhsppGt...lsEustuNlh......................................hhcs...............sp....lhTPshsp...s.hLsGlsRptll.phstt..sh.....lp-pslshp-lt.puc.....phalssohtslhP...lpplsst.h...........t..ht.l....hpth	................................................................................................................................................h.cpHhpRLppS.uctl..............h.hs.h.s.h.c.p..........................................l.h.p..t..lpphl......................ptst...........hsss..hlR.h........l.h..t.s...s...s....t..h...u..ht.sstt....h................................sthhhh.h.th..t.s.h..p.h..h..h...s..p..t...h.p..h...s..s...ts.h......................................................hsthK.s.s..s...ph...s....ssl.hspptA......................tpp.......Ghs-........s..lhls....t..p.Gh...............lsEsussNl.F......................................hh....c..s.................................s.p..........lhT.Psh...ss...........s..lLsGI.TRp..sll..pl..Acp...h.....u..hp....................lp.E...c.p...l.s.....h.c....-Lh...pA..c................Esahsuos..s.....lsP.........ltp..l..p..ththt...............u.hh.t.h............................................................................	1	919	1864	2466
+1191	PF00266	Aminotran_5	aminotran_5; 	Aminotransferase class-V	Finn RD	anon	Prosite	Domain	This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.96	0.70	-5.72	45	23746	2012-10-02 18:26:03	2003-04-07 12:59:11	14	88	5192	153	7010	41460	18473	338.30	19	85.74	CHANGED	lYLDuAAToppPpsVl-uhpcaYpphtuNlHR..uhHshuppuopthEpsRcpVApalsAps.cEIlFTpGoTc.ulNLlAtuhttt.....lpsGDcIllophEHHANllPWpplucppGsplc..hl.slsspGpl-..lcpl.pphl...s.scT+lVulsalSNlhGs.lpPlpclsphs+p.t.GAlllVDuAQulsHhslDlpplssDFhuFSGHK.hhGPsGlGlLYs+cchLpph...Ph.hGGpMlpplsh.psts....apphPh+FE.AGTPsluuhlGLusAl-al.ppluhstlpp+pppLtphshppLts.lsslpl..hG.s...pppsulluFsl.pslcs....pDluphLcpp.GIAlRu..G++CA.....Phhthhsls.......ushRsS.hshYNTp--l-pl	.........................................................................................................................................ah...sus.s...h.s...t....l.h.p.t....h....t.......h..........t..................u..s..s.....p...........th.p...t.h..u....t........p....h...p.....p.....h..h......c.....p..u...R.p.....p.l..t.....p......h......l......s......s........p........s.............p........c......l.....l...a..s..p.....G.........u.T....p....u.h.........s.............h........s..............h..............t....s...h......................................................h...p.............t...........s........c..................c...............l..............l...........h.............s....t.........h....-.............+......h......u......s.....h.......................s......h..........p.....t......l..........t.........................p......t.....G........h........p.......l...p....................h.l......s.......s.....s.............t........s......u.......h.....l..s....................h.p.p..l.....p.t..t.l............................s...s......c.......s..........t.......l......l.....s.......l....s.....t..s....s.....s..................h...G....s....l....p.....s.....l..............t..........p.......l.........s..............p........h........s...........+................p......t.......s...........s...............h........h........h........l...D...........u............s..............p...........u............h...........u...........p...........h.............s...........l...........D..........l.........p...........p.........h..........s..........l.............D............h............h......s.......h......o..u........a.....K...h.....h......G....P.....t.....G.....l..........G.....h.l........h.s.....+........c....p......h.....h..........t..........p.....h.................t...s.........h........h......h......u..............u....t........................................................p.t.ts.........................................................h....c.....s.....G......T................s...h.....h.....s.......l........h......u........h..........s.....t.....A.....h......c.......hh......t..................p...........h................s.................h...................p................t.................h.............t...................t......+...t...p.............p..........l...t..............p..............h....h......h.......p........t...........l........p.....p......h.........s............t............h.....t...l...............................s.....................t........................t..................t.......p.......t..................s.......s.......h......h....s....h.....s......h......t......t......h...c.s...............................p..t....l...h....h....h....L...p...p.....t....s....l..t...lps........G....ptss..................................................................................sshRhS.h....h...s...t.plp..................................................................................................................................................................................................................	0	2396	4497	5949
+1192	PF02293	AmiS_UreI		AmiS/UreI family transporter	Bateman A	anon	Bateman A	Family	This family includes UreI and proton gated urea channel as well as putative amide transporters [1].	25.00	25.00	28.00	27.70	24.90	21.80	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.30	0.71	-4.60	24	489	2009-09-10 14:59:15	2003-04-07 12:59:11	10	1	261	0	51	381	6	180.40	56	94.65	CHANGED	Mh.GlsLLYVGAVLhlNGLhlLG+lss+ssulhNlFsGsLpllsshhhlhsu................s.ucstslhuuAsshLFuFTYLaVulNplhsh.Du+GLGWaSLFVAlsAlshuhhu.hsss..........tchhhulhWlhWulLWhhFFLlLuLt+.plpphsualsllpGlhTuhlPuaLhLsGha	....ML.GLlLLYVGhVLlsNGlstLsKVDsKSsAVMNhFVGGLSIlsNlllIsaS................hu..pchsoaYusATGLLFGFTYLYsAINahFGL.D....hRsYuWYSLFVAINslPuAILS..aoshh.......hscusWaAIIWLAWGVLWLTuFIENhLK.....h.sLG.KFTsaLAIlEGIlTAWIPAaLLFhp+W.............................	0	15	38	47
+1193	PF02461	AMO		Ammonia monooxygenase	Bateman A	anon	Pfam-B_2301 (release 5.4)	Family	Ammonia monooxygenase plays a key role in the nitrogen cycle and degrades a wide range of hydrocarbons and halogenated hydrocarbons.	24.40	24.40	24.40	26.10	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.88	0.70	-4.65	8	15067	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	915	12	14	15207	1	149.70	61	93.12	CHANGED	uAutSsh+S+AEAstssRThDalhLshLFhllLGuYHIHhMLThGDWDFWlDWKDRRhWPTVsPIVuVTFPAAAQuaFWE+FRLPFGAThsVLGLLlGEWlNRYhNFWGWTYFPINhVFPouLlPsALaLDlVLhLSpSallTAlVGuhGWGLLFYPuNWPIlAshH.PsEhpGhLMSLADlhGFpYVRTGTPEYIRMVE+GTLRTFGKDVVPVAAFFSGFVShLlYFlWWalGKWFSTs.+alpp	..........................................................................................................................................................FahWo....aYPINF.VhPS.oM..IPG.ALh.hDslLLLT.pNWhlTALl.GGuuF.GLL...F.Y.PGNWP.IFGPTHLPl..Vs.EGs..LLSlADYpGahYVRT..GTPEY.V.RlIEQ.GSLRTFGGHTTVIAAFFuAFhSMLhahlW.WYhGthasss..a...h....................	0	6	11	13
+1194	PF00909	Ammonium_transp		Ammonium Transporter Family	Finn RD, Bateman A	anon	Pfam-B_596 (release 3.0)	Family	\N	19.20	19.20	19.30	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	399	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.45	0.70	-6.00	25	6224	2009-01-15 18:05:59	2003-04-07 12:59:11	16	40	3496	34	2233	5420	6440	367.80	30	87.31	CHANGED	sahllsuuLVhaM.psGhuhhpuGhs+sKNslN..hhhhshhshsls..slhahhaGauluFGps....hsuhhGs..........hthshhshsssshsphh.............hhFQhsFAs.sssuIlSGulAERh+hsuallauslhssllYsshuHWlWs...........sGahsphssh..........DFAGusl.VHhsuGhuGLssAhllG.Rhs+h......pstshpsHslshshLGshlLWaGWaGFNuGSuhshsshsts.............sslsTshAuAsGulshhhhshlpp..GK...shltstsGslAGLVAI.TsusuhVs.PauAlllGllAGllshhuht....hLpp+l+lDDslsshslH...GhuGlhGslssGlFut.th................sshhtGss....t.LhhQlluhhsshsauhssshllhhllshhhs..LRlot-pEhhGlDhspH.u-suY	...............................................ahhh.sshLVhh..M...h.....s.......G.......hAh...h...uG.h.l.R..p.K.N.s..l..s.......hh..hp....shhshuls..sl........ha...h..h.h...G..aulu......F..ut......t.....................h.s......s..h.hGs................................................h.h..t......s...h............t.......s.......s...h......p..h.h................................h.h.hF....Q..h.hF.Ah.....l.ss...........u...l...l...s........Gu....hA...E..R...h.+..asshl.lFssl.hssl.lYsslua..h.lWu............................................s.G..a..l....s....p..h.Gsl..........................................................................DFAG....usV.VHhsu......G..hu......u....Lss..uh......h.....lG......t.Rh.shh.........................tpsh.....s...H.........s..l.sh.shl.Gs.h........l.L...W.hG...Wa.G.F.Nu...G..Ss.h.s.s...ssh.ush.........................shlsThlAs.Auus..l................s...h....h....h....h....p.....h...h...ht..................s.K......s.......s....hhs.hhsG.slAGLVu..........I.....T................su..s.u..............h.....ls....shuAlllGhl..u.G.hl.shhuhp..............................hlp...p.t....l.....p....h....DDsl.s.shulH......GlsGlh...Gs....l...h...sGlFustsh.......................................................h..h.h..h....st..........pl..h...h...Qlhu..h.h.hsh...s.ashls....shll....h.hllchh..............hs.......LR..l........s..p-p..E..h...G.lDhs.H.ut.s...................................................................	1	776	1422	1922
+1195	PF05145	AmoA		Putative ammonia monooxygenase	Bateman A	anon	COG3180	Family	This family are annotated by COGS as putative ammonia monooxygenase enzymes.	23.30	23.30	24.20	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.86	0.70	-5.38	8	1520	2012-10-02 17:14:55	2003-04-07 12:59:11	7	4	1297	0	296	1116	1205	282.70	30	90.48	CHANGED	aMlGsllAuIlsspht.hslphshhhh.......tsuQsIlGltIGtplosslltslhspaslllsssllTlLuuslhualh+RhupsshsTAhauohPGGuotMlslu.pchGAsptlVuhsQshRllaVshssPhlsphhlss.......ussshshhhs....lslthlslLhhsuhlsuhsuphL+hPuPaLLuslLluAlVphG......hslphtLPsahhuhuQhllGhsIGsphs+shhtptsRhhhtsllsslhhlhhushhAhllohLssl-hhohhLuhsPGGlsphulsAtuLp.h-suhVsAhQshRlLhlLhlssslh+ahp+hts	....................................hhGshlss.llhs.h.hh.....hpl....p....h....Ph.hh...........hu.sllGs.lutsho..sl.ltsltt........h......l.lhlh.l.hsll..u.....h.l.hu.a.l....h.h....+.h..........u.............t..l.s....h............t.......Tuhhus.PGu...hu.tMl.shA..p-h.s.A.sh..thVuhhQhlRllhVshh.ssh.ls..th.h..hss..................................t..ss.s...t..h..h..hhs......................hsh.t.......l....llhh..l..h..u....h..l.u.u.h.h.....up...hl+.....lPusthLsPhl.s.su.l.h.phs.......thl.s.h.p..L..P...p...a.L.l.shA.hhlGhpIG.l..ta.s+th.hht..th.Rhlsth.llshh.hL..l.hh.sshhuhhlshhh.p..l.shhssaLusuPGGlsplsllA..hsss..ADhuhlhuhQslRlhhlLhh...s...P...sl.h+hh.p...s.....................	0	74	166	237
+1196	PF04896	AmoC		Ammonia monooxygenase/methane monooxygenase, subunit C	Mifsud W	anon	Pfam-B_6611 (release 7.6)	Family	Ammonia monooxygenase plays a key role in the nitrogen cycle and degrades a wide range of hydrocarbons and halogenated hydrocarbons. This family represents the AmoC subunit. It also includes the particulate methane monooxygenase subunit PmoC from methanotrophic bacteria [1,2].	25.00	25.00	34.70	34.70	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.61	0.70	-5.35	9	127	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	57	12	24	127	22	191.30	46	94.37	CHANGED	sspssususA.hsps.laDh+hhhlGlhshhsFYlhlRhYEpsaGaptGLDSFuPEFppYWMslhahEhslEhlssLslhGaLWKTRD..cslsslsPREElRRhFhhlhWLsVYuhAlYWGASaFTEQDGoWHQTlIRDTDFTPSHIlEFYhSYPlYIIhGVuuFhYA+TRLPhFu.KGhSlsaLhhhsGPFMIhPNVGLNEWGHTFWFMEELFsAPLHWGFVhFGWhuLuVhGVslQllsRhpcLh.sh-hsts....c	.................................h.s...hhhshhhh.hhhhhh.hYpthauht..tGhD.htPtapphWhshhhhph.l..h.h.hhhualhho.Rc.....cph.slsPp..El+Rhh..hhhalshYhhu.laauuSaFsE.QDuoWHQsllRDTsFTPSHll.FYhSaPhalhhGhushhYAhTRlPh.at...cuhshshhhhlhGPhMlhPNVGlNEWGHsFWFMEELFsAPLHWGFVhaGWsu.LuhhGlhhQhlschspLh.ch......h............	0	12	19	23
+1197	PF03782	AMOP		AMOP domain	Bateman A	anon	[1]	Domain	This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges [1].	25.00	25.00	25.60	26.20	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.45	0.71	-4.21	15	277	2009-01-15 18:05:59	2003-04-07 12:59:11	12	32	81	0	184	274	0	146.50	32	15.41	CHANGED	hspspC.cWlpsc.chL.sah....p-LPo...CPCohsQuhhDp.........uRFhs.hcsst..+pphshapPGAhaClRS..sspuSst.Gu.................QpCCYDssGpLh.....................sRG+shGsPshhps.hsPtL.paphDlhPahhC........Chas-p.uh.Ctha.hcR	......................................shspCppWhppc.....chL.p.ah.....p-Lss...C..PC....ohspshhDp..........uRhh..hssst...........ppphs.h...apsuAh.a.ClRS.....hpuosh..uu...................QpCCYcssGpLl.....................sRG+s.hGsPshhps......h....sPtL.Ha.hhDllPahhC...............shhs.....s..pp...Cp....c...................................	0	57	70	120
+1198	PF04739	AMPKBI		5'-AMP-activated protein kinase beta subunit, interation domain	Kerrison ND	anon	DOMO:DM04946;	Family	This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex [1]. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known [2].  The isoamylase N-terminal domain (Pfam:PF02922) is sometimes found in proteins belonging to this family.	21.50	21.50	22.20	21.50	19.70	18.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.39	0.72	-4.15	56	516	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	289	36	306	507	2	114.60	35	32.87	CHANGED	........tsP....tpas...splPsh..p.............................pph.pPPtLPPaLppsl........LNp.ss................................................................................ppc-.........sshL.....shPsHVlLNHLhspu..I+ss..VlslusTpRY+pKaVTpl......lYpPh	....................................................................................................ts...............................................................spcphpsPPhLPPaL.hpsl........LNpsss......................................................................................................................................................................hps-..............sulL.P.PNHVhLNHLastS...IKcu..VhslusTpRY+pKYVTslLYKP............................................	0	85	165	252
+1199	PF02166	Androgen_recep		Androgen receptor	Mian N, Bateman A	anon	IPR001103	Family	\N	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.48	0.70	-5.61	3	248	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	130	3	28	232	0	263.10	50	56.51	CHANGED	GLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGAsL.......QQQQE.............TSPRQQQQQQpGEDGSPQAHpRGPTGYLALDEEQQPSQQQSALECHPESGCVPEPGAAsAASKGLPQQPPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEAGTMQLLQQQQQE.................AVSEGSSSGRAREAoGAPTSSKDSYLGGTSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGGPPAVRPTPCAPLAECKGSLLDDSAGKGTEETAEYSPFKGGYTKGLEGESLGCSGSSEAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGGGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGP	...........................................................................................................pEslQsPusppsps.s.shAPPuspL.................Qp.....tp....................................pp.....pp....p.............QQ........s-ssSsps..Ru.suYLsL-ccp..p..su.....................................................................................................................p....................................................s......t......s....s.RsREssuss.S...SKDsalG......us..oTISDoAKELCKAVSVShGLuhE..........u........E......t.t...........s..s..c.t.........pt-pha.s................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	3	7
+1200	PF03139	AnfG_VnfG		Vanadium/alternative nitrogenase delta subunit	Mifsud W	anon	Pfam-B_1227 (release 6.5)	Family	The nitrogenase complex EC:1.18.6.1 catalyses the conversion of molecular nitrogen to ammonia (nitrogen fixation) as follows: 8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP <=> 8 oxidised ferredoxin + 2 NH(3) + 16 ADP + 16 phosphate. The complex is hexameric, consisting of 2 alpha, 2 beta, and 2 delta subunits. This family represents the delta subunit of a group of nitrogenases that do not utilise molybdenum (Mo) as a cofactor, but instead use either vanadium (V nitrogenases), or iron (alternative nitrogenases). V nitrogenases are encoded by vnf operons, and alternative nitrogenases by anf operons. The delta subunits are VnfG and AnfG, respectively.	20.50	20.50	21.40	115.70	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.35	0.71	-4.28	20	108	2009-09-11 14:59:01	2003-04-07 12:59:11	10	2	80	0	25	83	0	111.80	49	82.15	CHANGED	hcs+l-pLhDYIhKpCLWQFaSRuWDREcQNEGILsKTtplLsGEsscpsTP.tDRsYasDAlsLAcsaKp+aPWlsshsK-EI+pLhpuLKpRlDalTITGSLNpELTcppY	...ps+lDpLhDYI.cpCLWQFaSRoWDREcp.EGlLspsscLLsGE.s..huTP.pDRhaasDAlslAsDh+c+aPWhsphsK-EIptLhpGLKsRlshlTITuSLNcELscchY.	1	9	18	20
+1201	PF00212	ANP		Atrial natriuretic peptide	Finn RD	anon	Prosite	Family	\N	21.20	21.20	21.90	24.30	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.78	0.72	-3.87	39	340	2009-09-10 22:47:03	2003-04-07 12:59:11	13	3	149	7	90	346	0	32.00	49	25.16	CHANGED	phhpstcps+..h....sGCFGt+lDRIGShSGLGC	................s......tts+.phhs....sGCFGh+lDRIGohSGLGC.....	0	3	11	36
+1202	PF03452	Anp1		Anp1	Finn RD	anon	Pfam-B_4441 (release 6.6)	Family	The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for proper Golgi function. These proteins co-localise within the cis Golgi, and that they are physically associated in two distinct  complexes[1].	28.80	28.80	28.80	29.00	28.50	28.60	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.77	0.70	-5.25	49	428	2012-10-03 05:28:31	2003-04-07 12:59:11	9	10	142	0	314	409	3	260.40	42	61.82	CHANGED	phstsslpa..YDLsphpuos..cuhtpcE+VLIloPL...upa.....lshaacsLhpL.TYP..HcLI-LuFllscop..DsshptLtptlpclQ.................................................p.ts..tpppFtplpIlcpDFsphl..uQshp-RHuhpsQt.RRchMA+ARNhLlhssLpPtpSWVhWhDuDI...csPsolIpDLhpHs+DVlVPNVap.h.s..s.....s.pPYDhNSWh......ES-puLcL.AssLs-D-lI...VEGYA.EasTaRshhAahtD..spGsscpphpLDGVGGsulLsKAcVaRs..GuhFPuFs	................................slphaDLsphpuos..puhp....p.cE+lLlloPL+s.uupa........LshaFs...pLhpL...TYP..HcLI-LuFLVuDop..DsThshLpptlpclQ..................................................p...ts...pptFtplo.Il....c+.DFsth.......l......uQshp-RHu..htsQs.RR+hMA+ARN.aLL.ssLc.....P.tcSWVhWhDsDl...psPso.llpDL...hp.....Hs..KD....llVPN.....lap.h..s..s.....stpPYDhNSWh......ES-pulpL.ApsL.sc..Dsll...VE.G.Ys.Eas...T.a........Rsh.hAah..t...D...spussctEh-LDGVGGsulLsKAcVaRs..GshFPsFs...........................	0	61	156	266
+1203	PF03374	ANT		Phage antirepressor protein KilAC domain	Mifsud W	anon	Pfam-B_3485 (release 6.6)	Family	This domain was called the KilAC domain by Iyer and colleagues [2].	24.80	24.80	24.80	24.90	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-9.94	0.71	-4.02	66	1631	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1146	0	193	1289	13	109.40	28	45.26	CHANGED	Lc...pp.....ltttpPKspahDtlssus.ssltlsplAKhl.......slu..tpcLhpaLp-.pshlh+...sssphhshQct.hctGhhphKpsshtpss.Gp.cht...hss+hTsKGp....talhphlhppshht	...........................ppp..ltt.tPKstasDtlhpu.....p...sslhlsphAKhl...................slu.tpcLhpaL+c.....pshlh+.....ssp............p.......hPhp.ch...hspGhF.pl..K..ps..shs....p...ss...Gt.hp.hs...........hs.s+lTsKGp....talhphhhptt..h...........................................................	0	53	133	161
+1204	PF04715	Anth_synt_I_N		Anthranilate synthase component I, N terminal region	Kerrison ND	anon	DOMO:DM04829;	Family	Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the  biosynthesis of tryptophan.  Component I catalyses the formation of  anthranilate using ammonia and chorismate.  The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family  (Pfam:PF00425). This region is involved in feedback inhibition by tryptophan [1].  This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-11.08	0.71	-4.17	111	5751	2009-01-15 18:05:59	2003-04-07 12:59:11	8	30	3830	10	1512	4547	2202	145.90	22	28.89	CHANGED	shhsPlshatplts...pt.......shlLESs.....t..ssp......uR.aShluhsP.........................ht....hpssththtt..........................tt.....p......................shph......Lcphhsphp.h.............t..P..FtGGhlGYhuYDh...hctlc.ph...........sshs.hP-.hthhhh..-phllaDHhppphhl	........................................................................................................sshthatp.Lpt.............tt.............hshLLESs...................t.........stp................uR.aS.llsh...ss......hhp.....................lp...........stspp.splpt............................................................tptph.ppts......................shph...............Lc.p.hh.p.p.hp.....................................t..s....F.sG.GhlGhhuYDh..................lpthE..pLs....p..........htsc.t..hP..D..hthhlh...-plllhDHhcpphh...........................	0	477	968	1295
+1205	PF03497	Anthrax_toxA		Anthrax toxin LF subunit	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	28.20	27.20	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.92	0.71	-4.44	7	96	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	91	65	11	94	0	173.00	35	16.76	CHANGED	t+sh.....s.tshctsGlssE..ascuhtplAcEpNshlhhRsVN.huToLIcpGh.uTKGhsl+uKSSDWGPp..AGaIPhDtphSK.......htsssttlp+hs.tsppul........tutuhsplsLplscpRlsELppsGshshstcsht....hshphssupphEFclppssss.atl.hhth.ss....lpVhGsshsht	..............ps.t.hctsGlssE..aupshpplApchNslIGlRsVs.lupoLIcpGh.soKGhplKuKSSsWGPp..AGFIshDQphSK.......hsssthplp+hNhpstKul........pttuhsplsLpIo+pRlsELhcs.s.lshhtcph..........hssptsss.pp...hEF...c..lp..p...p..sp...s.h..l.hhsppsp.....lpVhsss.p..s..................................................................	0	4	8	11
+1207	PF02522	Antibiotic_NAT		Aminoglycoside 3-N-acetyltransferase	Bashton M, Bateman A	anon	Pfam-B_1432 (release 5.4)	Family	This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic.\	     The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	25.00	25.00	26.70	26.60	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.32	0.70	-5.11	52	757	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	561	30	138	557	210	200.70	28	82.97	CHANGED	hVHuSlpslGhlsGGsp......sllpALh-slu.pGTllhPstoss.ssst............t..t.h+tphPsaDPsho.so.cshGhlsEhhRphPushRSsHPthShuAhGtpAptl.hsspshs.saGtpSPLu+lh..chsGplLhLGssh-ssThlHhAEthushstcphtphp.....slh.tsGpph.Wpphpchshss.........pt......Ftplupsh.pppsh..hppuplGsAp.spLhst+-hlchuhp.alppc	.........................................hVHsslpphG...h.l..sus.......sllpulhcsls.pG.TllhPs.o.p.spst.............................saD.tho..o...shGhlsEhhRp.hs.s..shRSsHPhhShuAhGtpuc..l.h..c...th.s..........shGcpSPhtplh..c.hsupllhlG.s.s..h.p.ss.T.h.lHhuEtp..hs......hchhptht.......slh..ppGphh..hpph..pphs.hst.............-t.............h.plst.....h...pppt..............hppsplusut.hpl..h.ptpchlchshphhpt................................................................................	0	48	95	117
+1208	PF03230	Antirestrict		Antirestriction protein	Bateman A	anon	Pfam-B_3190 (release 6.5)	Family	This family includes various protein that are involved in antirestriction. The ArdB protein Swiss:Q47057 efficiently inhibits restriction by members of the three known families of type I systems of E. coli [1].	25.00	25.00	25.00	26.50	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.15	0.72	-4.00	27	1097	2009-09-10 21:28:14	2003-04-07 12:59:11	8	3	438	3	52	624	10	95.40	57	64.17	CHANGED	Lss.cYsGGaWpFYpLusGGhaM.APss....ppchplhssh.NGapGplSA-AAGIlsoLashu+h...utcsp....sDthhcpYapLR-aA..tpHsEuusIapAID	......................LC--YsGGhWshYTLsN..G................G.AFM.AP-s....s-sahLFNuh.NGN.cAEhSsEAAGIsACLhsYS...H+.....As+TE..................saAMos....HYY+LRDYA..LpH.....P..ECuAIhRlID...................	0	2	13	38
+1209	PF03589	Antiterm		Antitermination protein	Griffiths-Jones SR	anon	PRODOM	Domain	\N	21.60	21.60	21.90	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-10.19	0.72	-3.90	21	1401	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	423	0	52	693	1	94.20	30	76.57	CHANGED	ss..losuspsssucu.......sAlshtpoctp.Ghsla.....suttGhschssppAhctlhphs.slspps.hh+phcshhcshVhpshtp.uaA-hshut	...................p.s.lossspsspucu.......sAhshspoctt.Ghsla.....CuthGhSp.ssptAhptltphs.slsshs.hh+plps.hcshVhphhtp.AaADhphsA.........................	0	2	8	26
+1210	PF01786	AOX		Alternative oxidase	Bashton M, Bateman A	anon	Pfam-B_1154 (release 4.2)	Family	The alternative oxidase is used as a second terminal oxidase  in the mitochondria, electrons are transfered directly from reduced ubiquinol to oxygen forming water [2]. This is not coupled to ATP synthesis and is not inhibited by cyanide, this pathway is a single step process [1]. In rice the transcript levels of the alternative oxidase are increased by low temperature [1].	22.50	22.50	27.10	26.80	22.30	22.10	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.23	0.70	-4.92	60	637	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	343	0	287	637	966	195.30	41	67.21	CHANGED	ssaspcphp.slphtH+pspshuD+lAhhhl+hlRhshDhhohh....................................................................................................hocc+ahsRhlhLEolAGVPGMVuGhlRHL+S......LRthcRDt...............................................................GWIcoLLEEA.NERMHLLTFlcls.cPuhahRhhlhsuQGVFaNhaFlsYLlSPRhsHRFVGYLEEEAVpTYT+hlc-l-s.G+.l..h...shsAPpIAlcYWphsc.p......................................................................................................soh+DllhhlRADEA+H..R.-VNHThus	......................................................................................................................t.H.p.stph.DphAhhhl.c....hlRh.h.Dh........................................................................................................h.h.p....p+a.h.pRhhhLETVAuVPGMVu......G...hlhHL+S......LRphc+..s.s.....................................................................G.W..I..+.sL.L-EA.NERMHLhTFh.c.lu....pPt......WapRhllhssQG..VFaNsa..FlhYLlSP+h.uHR.hVGYLEEEAlpoYTchlc-.l-p...Gp.l........shsAPtIAl.........pYWphsp.p......................................................................................................ssl+DllhslRADEAcH...R...clNHhhus.......................	0	104	194	247
+1211	PF01261	AP_endonuc_2	AP_endonulease2; 	Xylose isomerase-like TIM barrel	Finn RD, Bateman A, Studholme DJ	anon	Prosite & Pfam-B_3980 (Release 7.5)	Domain	This TIM alpha/beta barrel structure is found in xylose isomerase (Swiss:P19148) and in endonuclease IV (Swiss:P12638, EC:3.1.21.2).  This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae [1].	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.09	0.70	-11.13	0.70	-5.05	311	17202	2012-10-03 05:58:16	2003-04-07 12:59:11	19	48	4117	343	4623	13647	4257	209.50	15	68.04	CHANGED	lpts...tphG..asslElhht..tth.........................hpplpphhcctulp......................h..hth.......................................ttt........hpthpptlchu...ppl..............G..sph.......lshhsu.............................................................h.ttstp....pshpphhc..slpplschst..ptG....lp.lslEshstpth..h.......................pchhpllcplsptt...ltlthDssHhhht.................ttshhphlcphssp...............lttlHl..pDs..................................ttspch..GpG.pl	..................................................................................................................................................................................................t.stphG.hps.lc.h..h...h...........th...................................................................hp.ph.t.phh.p.pt....s..lp.............................................l.....s..h..s...h...h.t...hhh..................................................t..........t.t..hp.t.h....p.p..s..l...ch.u.......p.tL............................G...s..ph.............l..s..hh.su...........................................................................................................h.ht.t.s.p...................psh.pp.h.h..c....sl.p..t.h.s.c.h....h....t...ptG....................lp...lslE.s.....h.ss..t.h.h..tth..........................pph...h..p..l...l...c.....t......l....s.........p............t.......p........lt...l...t...h.....Ds....sHh.hht........................................tts...h..t...p....h...l......p.....p..h.t..st..................l.ttlHl.....pDs........................................t....t...h...GpG.................................................................................................	0	1580	3025	3904
+1212	PF01636	APH		Phosphotransferase enzyme family	Bashton M, Bateman A	anon	Pfam-B_840 (release 4.1)	Family	This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation [2]. This family also includes homoserine kinase. This family is related to fructosamine kinase Pfam:PF03881.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.76	0.70	-4.64	244	16611	2012-10-02 22:05:25	2003-04-07 12:59:11	18	143	4228	100	5858	21791	6494	227.30	12	63.11	CHANGED	phphhs.sG.hsst.sahht........ssp...t........phl.......l.+h........................hpss......htph.t.....tph.p............hh..phLs.ppth....s..........sPps...l........s....t...tthtth......................hhthh..phlsGpthtp.................t.tthhp..thuphLs....................................plHph.....................t...........................ttshs..................................................tht..t..........hht......h.h......................pth.hph.............th........ht.phhp.........phhp...............................hhsthtpths...................hslh.HuD.hpssNllhs.............tsspl...ullDa....ppushus.hhDl......uh..h..h.......t.hs.ths...................sphhtth....hptht.............hshtphphh	...........................................................................................................................................................................................................................................................................................................t....................h...h.....................................t..............ph.h.......h.+h...............................................th..................t.h..t.....................................hh.......th....l.t...t.t.th.......................................................s..P.p.h....h...............................t..................t...hh...........................................................hhlh....p..h..l..t....G.p...htt..................................t......t.h...h.p........th...s...p..hl.t...........................................................................................................p.l.+p....h.....................................................................t............................................................................h.t...........................................................................................................................................................................tht........t........................h...............................................................................t.h....ph...............................th.................ht..th.t...................t...hhp......................................................................................h..h..p.t.h..t..p..t..h.....................................................ths.h.h...H...u..D..h.p............s.Nl.l.hs...........................tss..p....l....s...l....l..D....a.........p.t.s..s....h....u....s......h....h......D.l.................uh...hh...................................................................................................hh............................................................................................................................................................................................................................	0	1538	3487	4810
+1213	PF02558	ApbA		Ketopantoate reductase PanE/ApbA	Bashton M, Bateman A	anon	COGs	Family	This is a family of 2-dehydropantoate 2-reductases also known as  ketopantoate reductases, EC:1.1.1.169.  The reaction catalysed by this  enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway [2].  ApbA and PanE are allelic [2].  ApbA, the ketopantoate reductase enzyme is required for  the synthesis of thiamine via the APB biosynthetic pathway [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.78	0.71	-4.77	98	4828	2012-10-10 17:06:42	2003-04-07 12:59:11	11	38	2913	28	1377	9328	3628	147.80	22	45.49	CHANGED	ItllGuGAlGuhhustL..tp.uGpc.....VphlsRsp.phpt.lpppGlplpssp........tphhh.s.hthsss.............htthDllllssKuhpsps.slpt.ltshlsss...s......hllhlQNG...lGpt.-tlpphh.....st..p.pllhGlsh.huutpps.......supl....pps...u..tuphhlGthss	....................................................................lsll.G.s.G.A.l.G.s.hh.u.s....tL.....tp....u....Gp-..........................Vsh......l..s..R..t....s....p...hps....l..p....p..p.....G..l.p.lptts..........tphh.h........h.thsst............................................hsthD..ll.l.l.......s.......s.......K....u........h..........p........l.....s.....s.....s.lpp...l...t..s..h..l..sss...o.................hl...l..h.....l....pN..G.....................h..up...........-t.lt..phh........................................st....p..pllhGs.sh...hs.uthps.......................ss.tl....hhh....u...tsth.ls....s.......................................................................................................................................	0	390	813	1149
+1214	PF03256	APC10		Anaphase-promoting complex, subunit 10 (APC10)	Mifsud W	anon	Pfam-B_4273 (release 6.5)	Family	\N	19.90	19.90	20.10	20.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.18	0.71	-4.72	7	646	2012-10-03 19:46:52	2003-04-07 12:59:11	11	56	294	3	429	618	4	165.50	26	13.97	CHANGED	.ptsssssu.t..pphphtGh........hh-luppAhWolSSsK.G.GVc.hLRD-sh-TaWQSDGu.PHhlpIpFpK+sslphlslYhsaphDESYoPSplplcuGsshpDhp.lphh-lsp..PsGWVplslp...................Dspt..p.l+shhlQltlhsNHpsG+DoHhRtI+lYuP..p..t.shp.hht.....oohth.phsol	.......................................tt..tt............................................h...t..So...p......t.slt.....pL........pDssscoYWQS...DG...s................p...............s...H.hls.lphp.+.t..s...h.l....pplt..lhls.ptDcSY....hPs+.lslhuGsshs.s.....L.p................E........l..ps.....lpl.p...............ssGah.pl.l.................................................................................p.s...s....p.hph.hlQltlhps..pps....GhDT+lRtlclhu....................................hh..................................................	0	128	193	305
+1215	PF04110	APG12		Ubiquitin-like autophagy protein Apg12 	Wood V, Finn RD, Bateman A	anon	Pfam-B_9471 (release 7.3);	Family	In yeast, 15 Apg proteins coordinate the formation of autophagosomes.  Autophagy is a bulk degradation process induced by starvation in eukaryotic cells [1]. The Apg12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. It was first discovered in yeast during systematic analyses of the apg mutants defective in autophagy. Covalent attachment of Apg12-Apg5 is essential for autophagy [2,3,4].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.89	0.72	-3.79	6	282	2012-10-03 10:59:06	2003-04-07 12:59:11	8	8	246	2	197	973	70	83.60	40	53.46	CHANGED	KIsl+L+AlGssPlLKpppasVssocohutlIpFL+KhL+l.hs-pLFlYVNsoFAPSPDppltsLYcsFu...oDu+Ll.lpYCto.AaG	...........................Klslhh..+slG.s.sPll..K....p.p..haplsso.pphp..sllcFL.+.KtL.....+.........h...........s.......-........p.............lFlYl...Np.......s.F.A.PuP.Dp.tlusLa.c.s.Ft..........ssscLl.lpYsto.AaG..................	0	65	107	165
+1216	PF04108	APG17		Autophagy protein Apg17 	Wood V, Finn RD	anon	Pfam-B_71163 (release 7.3);	Family	Apg17 is required for activating Apg1 protein kinases [1].	25.00	25.00	25.00	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.35	0.70	-5.67	19	172	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	138	\N	130	174	0	344.20	21	54.31	CHANGED	hpahhtA+poLspspplCp.Apphlsss+ptLppplh.pt+.hpFLhpuLppQhchLhp.....shsphhhtpptspp.hsslhppLpsups+LcpplphLcpThVph.h..............sp-s+sLtDFlspcsl-.Lptslpphlccssth..ptpl-s.htta-s.lpplppth....tpph+phpp....pspht.t.pst......s.hsslsptlpuLE...pEhAslLpSLopHaDhChpuhchh.s.............................................pshstsEhcEhlpVLpsDAtEl.-VltELpsthsphcpthcs....lpsphsphpphastspslhpplpphtp.phstYlthhpshsphhpcppt.........plpptlsplppLspaY-pFlpuYpu.LlhElcRRpts..cp+hccllcpsppcLppl.-pDhcpRppFhhc.GDYLPp-l.WPGhhcpssh	...............................................................h.tah.tuppsLtphp.lhp.Ap..h.thpt.hpp......p.htalhttltpQhthl.t.....hhtth....t.spt.h..thhpphp.h.tplpphht.Lcth.s...h..........................................tpt.ppLhDFlsppslp.l....p..lpph..h..ptth-t....thpp.hptlppth..............h.........................s..t.h.p..tphp...pthsphLpuLspHaD.shhh.c...........................................................t.hs.tpht.p.hpVl.pDstEh.slhhclpphhtphpt.htp....l..p.p....hsthpphhsshpphh.pplsphtp..p....h....spalt....thpshpphh.pptpp..................................plpsthpphp....pLpphYpsFh..p..uYss.Lll..EltRR+ps..ppphcslhcphpcpLsplh-....p-hcpRcpFhtchG-aLPp-l..hssh......s.....................	0	30	65	105
+1217	PF04111	APG6		Autophagy protein Apg6	Wood V, Finn RD	anon	Pfam-B_11747 (release 7.3);	Family	In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in  eukaryotic cells [1]. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the  carboxypeptidase Y sorting pathway [2].	30.00	30.00	30.00	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.09	0.70	-5.38	99	445	2009-09-10 16:48:33	2003-04-07 12:59:11	7	12	305	4	274	429	5	294.70	35	65.03	CHANGED	PlCp-Cs-hLlcpLcpplctspcEpcsYppaL......cplp.........................................tppstpp....h..pcclpp..lctEEpphhpELpclEpccpplsp-lpp.......hcpEtppLc..ppEc.paacchsphphphhchpc-hpSlpsphphspppL-+Lc+oNlaNssFcItH.....-.G.tFGT..INGhRLG+......LssssVsWsEINAAWGQslLLLtslAc+lshp...Fp.p.Y+LhP..hGSpSpIpchs..p.......................................phptLsL......auo.G......sh...phFh.....cp+FDpAMlAFL-slpQh....tppl...p..............ptss......t.....................h.........p....LP.Y..cI..p..cc+Itch.......SI+l..thspc-.pWT+AhKahLTNhKWhLAasSsp...tp	.................................................PlC.-Csc.hLl-thcpplp.sppEppsYtphLcpLp......................................................p.t.p.tpp...pthpp......clpp..lpt-EpplhpcLpplE.ppcttlspp.ltp..........lct.......ctpp.Lc..ppEt.pah+-hsphphp..hhphpc-.......hculpsphchsptpL-+Lc+TNVaNss...F....p..I.H................s.G..tFGT..INshRLGR......Ls.sss..V.-WsEINAAWGQssLLLtslAp.+..hs.hp...Fp.p.Y+LhP.hGs.aShlpphp....................................................ptpplsL..ass.s...sh....phFh.....pp+FD.pAMsuFL-ClpQhtc.l...p.............ptst.......................................thpLP..Y.ch....c..psKItsh...........................SI+h..thspp-..pWT+AhKahLoslKahLsasss....p........................	0	102	152	217
+1218	PF04109	APG9		Autophagy protein Apg9 	Wood V, Finn RD	anon	Pfam-B_12479 (release 7.3);	Family	In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in  eukaryotic cells [2]. Apg9 plays a direct role in the formation of the cytoplasm to  vacuole targeting and autophagic vesicles, possibly serving as a  marker for a specialised compartment essential for these  vesicle-mediated alternative targeting pathways [1].	21.70	21.70	25.70	23.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.15	0.70	-5.55	36	425	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	279	0	277	410	20	322.60	36	42.59	CHANGED	Ds-ltTlsWppVlp+lht.Lcc..tsshosp..............t.ps.....Kp+LsApDIANRIMR+ENYhIALh.NKslLslsl.......................slP.......hlpsp...........hLT+oL-WNlphslh...salFs.ppGpl+ppal+sppRptLupcL++RF.........hhsGllNllLuPFlllYhlLhhFF+Yap-a+psPusl.GsRpaoPhAcW+hREFNELsHhFp+RLshShhhAscYlsQFP..pshhsl.lh+hluFluGulsAlLllholh...Ds-sFhsF-lo.s+olLFYlulhGslhuls+uhlsc.......................-shV.aDPEtsLcpllpaTHYhPscW...cs+hHopcV+pEFspLaph+lhllLcElhSlllTPFlLhFsLspsu.spIlDFFR-aoVcVDGlGaVCpFAhF-hp.cssts	......................................................................t-lpshsWt.cV.p+lht.lpc.pp..thsht.......................................ppcL......sthDIhpRlhRh............cNYh..lAhh..NK........slLshph..........................................lP.............hht.p.h...........................hho+sLcaNlphhlh....t.hFp..pphplp.tpahp.......stp.......c......L.......uptLpp+h.........hhhulhNll.lsPhlll...a.llahFapYhp.h+..p.pPusl.GsRpao.huchhhRcFNE.L.H.hppRLshua...........AscYlspFs..pshhsh.lA+.lsFhuGulhulL..lhh...slh.......Dpclhh......scplLhhlslhGslhsls.Ruhls-....................................................................-phV......asPEth.hptlltahHYhPpcW...puphHs.p.....pl+pEFs.pLaph.....+hl...hlLcElhS.llTPhlLhF.l....pu..cIlDFFRpFTVcVsGlG.lCSFA.hDh.cpts...p......................................	0	94	148	221
+1219	PF04655	APH_6_hur		Aminoglycoside/hydroxyurea antibiotic resistance kinase	Waterfield DI, Finn RD	anon	Pfam-B_4369 (release 7.5)	Family	The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety [1,2,3].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.58	0.70	-5.23	9	681	2012-10-02 22:05:25	2003-04-07 12:59:11	9	5	456	0	126	779	46	215.90	33	83.38	CHANGED	RWcLptcGtshsscoShllPVh...psDGssAhLKlth..tc..pEptGthl.LsaWsGcGAVRlLsp-..sushLLERhsGsRsLspls.cttDcpAstllAthhsRLauspstPhP..LpPLp-hhsuLhpts.spt.st......cttL.tssAusstpLlusPp-.RsLHGDLHasNVLsusc.....csWLAIDPcsLhG-sGFDhAshhsss.tc......shcstclc+ph-llstslslD.tRlhsWslAhss.SusWthEDG	............................................................................................................................Wtl.........s.........s.suhlh.V.....h..s..G.t...............A.hlKh..........pE.h.....h..Lh.....h..h.s...G.p...G..A.s.c.lls.........tc.....................p.......s..hhLLEhh..utR....L.u......p.....l.....s..................s...D...p.....A...s...pl..h....A........p...l..hu...+........La....u..s..s..............s.h.....P..s........s...L....h...s.......lp...-...h.....h...s.s......hh..pps.....tp.s.st...................sppphh..hpsAt.h..s..c...p...l...h.u......s...s..u......-.........p......h...L.....HGDLHa-N..ll...t.......us........................cs.W.....L....s....ID....P.p.s.L.s.G-.sGF-h....ssh..hh.s....h-c......shs.s..p...p..l.tph.h-.hhs.c.slsl..D.cR.hhsashuhss.sAhW.ht..................................................................................	0	40	79	103
+1220	PF00807	Apidaecin		Apidaecin	Bateman A	anon	Pfam-B_1489 (release 2.1)	Family	These antibacterial peptides are found in bees. These heat-stable, non-helical peptides are active against a wide range of plant-associated bacteria and some human pathogens [1]. The Pfam alignment includes the propeptide and apidaecin sequence.	25.00	25.00	31.70	30.20	23.50	17.60	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.47	0.72	-4.26	2	104	2009-09-10 22:49:59	2003-04-07 12:59:11	12	9	4	1	40	92	0	27.70	92	82.49	CHANGED	hctcPEAEPGNNRPlYIPQPRPPHPRl.	.REAEPEAEPGNNRPVYIPQPRPPHPRLR.	0	40	40	40
+1221	PF04711	ApoA-II		Apolipoprotein A-II (ApoA-II)	Kerrison ND	anon	DOMO:DM04862;	Family	Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma.\	 Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge [1]. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear [1]. In bovine serum, the ApoA-II homologue is present in almost free form.\	       Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS) [2].	24.30	24.30	24.70	24.70	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.41	0.72	-4.09	5	38	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	26	44	15	41	0	73.20	61	73.18	CHANGED	QAEEoslQSLsSQYFQTVTDYGKDLMEKAKuSELQuQAKAYFEKTQEQLTPLVKKAGTDLlNFLSpFl-L+cQPAT	.............QA-EsslpSLhSQYFQTlTDYGKDLhE...KVKoPELQAQAKAYFEKo+EQLTPLVKKAGT-LlNFLS.Fh-Lc.p.pPA........	0	1	1	1
+1222	PF04691	ApoC-I		Apolipoprotein C-I (ApoC-1)	Kerrison ND	anon	DOMO:DM04729;	Family	Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein.  It solubalises lipids and regulates lipid metabolism.  ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons.  ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway [1]. ApoC-1 has been implicated in hypertriglyceridemia [2], and Alzheimer's disease [3].	27.60	27.60	28.40	30.60	26.80	27.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.86	0.72	-4.28	6	41	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	29	5	13	45	0	55.00	47	71.03	CHANGED	ss-hSSshpplsDKLKEFGNTLEDKA+sAI-cIKpS-lssKTRsWFoEsFpKlK-KlKss.	......tP-lussh....D+LKEFGsTLEDKA+psIp+I+QSEhssKTRsWFoEsapKVK-Klp.s.....	0	2	3	4
+1223	PF01333	Apocytochr_F_C	Apocytochrome_F; 	Apocytochrome F, C-terminal	Finn RD, Bateman A	anon	Pfam-B_1294 (release 3.0)	Domain	This is a sub-family of cytochrome C.  See Pfam:PF00034.	28.50	28.50	28.50	28.70	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.48	0.71	-4.26	49	697	2012-10-02 20:27:15	2003-04-07 12:59:11	14	5	642	30	66	553	134	114.80	74	37.15	CHANGED	NNslasAsssGpIopIpt..p-..............c....GGaploI.possGppls-plPsGP-Ll..VscGpsVpADQsLTsNPNVGGFGQs-sEIVLQsPsRlpGLlsFhhsVhLAQlhLVLKKKQFEKVQhA.EMNF	................NNTVYNAousGhVoKIlR..KE....................K....GGYEITI..scs.SD.GcQVVDIIPPGPELL..VSEGEsIKlDQPLTs...NPNVGGFGQGD.AEIVLQDP.LRVQGLLhFhASVILAQIFLV...LKKKQFEKVQLuEMNF......	0	16	40	56
+1224	PF01442	Apolipoprotein		Apolipoprotein A1/A4/E domain	Bateman A	anon	Prodom_1521 (release 99.1)	Domain	These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Swiss:P02647 Apolipoprotein A-I. Swiss:P06727 Apolipoprotein A-IV. Swiss:P02649 Apolipoprotein E.	90.00	5.00	90.00	5.90	89.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.09	0.71	-11.79	0.71	-4.81	46	1816	2009-01-15 18:05:59	2003-04-07 12:59:11	13	29	249	39	715	1765	2	196.40	12	86.35	CHANGED	thlp-shcplssYtpcLpppLsPhs...p-htspLsc-sptl+pcl......ppDlE-l+s+lpPahsElpphlppph-chRp+lsPhspcL+c......phppchccLpppLsshsp-..................h+sph......cpsl-sl+spLtPhs-ph+p+ls..................p+Lcpl+ppssspsp-hpsplpppl...ppl+c+lpstsc-l+ppL...............................................................................pPhsEshcpplhphhE	...................................................................................................................................................................................................................................................................................................................t.......................................................h.......ttl....................ttt...h.tt.htt.......t.......l...t....thh....p....p...h...p...p......t.l....t.p...p.......h.cp....l..pp....p....l...............s...s.......hhpphp.p......................pl....s........pp...s......ppl.....pp.p....ls.......sh...s...pp........................................................................................hpppl..................pp...ps....p...ph...p...splssh.......s....cpl...p......pphs............................................................................................pplpphp...p...p.l...s..p...ts.....p....p....ht...s.p...l..p...p...ph...........pphp...ppl....st.t....hp.......slpppl....................................................................................................................................................................................................................................................................t..t.th...........................tt......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	146	285	400
+1225	PF01583	APS_kinase		Adenylylsulphate kinase	Bateman A	anon	Pfam-B_578 (release 4.1)	Domain	Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate.  This domain contains an ATP binding P-loop motif.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.78	0.71	-4.57	20	3100	2012-10-05 12:31:08	2003-04-07 12:59:11	15	31	2402	54	1024	3172	2394	154.70	50	43.89	CHANGED	+GsslWhTGLSGuGKSTIAtALEcpLhppG.hpsYhLDGDNlR+GLN+-LGFSccDRpENIRRluEVAKLhu-uGllslsuFISPacp-RctARplhpp.........cFlEVFVDsPL-VCEpRDPKGLYKKARsGcIKsFTGIDuPYEsPpsPElhlcssppsl	.......................usllW.h.TGLSGSG..K..S..TlAsALEc.......tL....h....p................p.G.....hp.....s....Yl....L.D....G....D......N..l....R.....+.....G.....L....s........p.................D..........L.......G.....F.......S..c.....t..D.R........p..EN........I....R..R.....l..u....E..V....A.....+.....L.h.....s....-.u....G.l..l.s.l..su...F..IS.P.a...+.t..-R..ph..sRchlsps.............pF..l.E.......V.a..Vcs.P.Lp..lC..E....p..R..D........P........K.................G.....LY.+KA.....R.....u....G...E........I+.............s........FT......GI....D....u..s............YEs..P..p..sP..-..lplcsp...ph........................................................................................................	0	317	597	837
+1227	PF03440	APT		Aerolysin/Pertussis toxin (APT) domain	Griffiths-Jones SR	anon	SCOP	Domain	This family represents the N-terminal domain of aerolysin and pertussis toxin and has a type-C lectin like fold.	25.00	25.00	36.70	41.30	24.80	24.80	hmmbuild  --amino -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.83	0.72	-4.28	5	77	2012-10-02 16:37:33	2003-04-07 12:59:11	9	3	33	26	10	90	2	81.00	49	19.25	CHANGED	sEPVYPDQl+lsuLG..pGVCuscYRPLTR-EApS...l+sNLVuhMGQWQIoGLADtWVILGPGYNGEIKsGoAGuTWCYPToPsou	..................lYPDQlhhhsLG..ptlCsstYRPlTRpEApu...lKusllshMGp..WQIoGLAssWVIMGPGYNGEIK...G.o.A.u.sTWCYPssPs..s....	0	3	5	5
+1228	PF02610	Arabinose_Isome		L-arabinose isomerase	Bashton M, Bateman A	anon	COG2160	Family	This is a family of L-arabinose isomerases, AraA, EC:5.3.1.4.  These enzymes catalyse the reaction: L-arabinose <=> L-ribulose.  This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into  L-ribulose by the L-arabinose isomerases enzyme [1].	27.00	27.00	27.00	27.50	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.15	0.70	-5.49	38	1076	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	1019	9	200	697	49	349.80	58	71.66	CHANGED	M.hph.cphEhWFlTGSQHLYGpEsLcpVupcoppIssuLNsoupLP.hclVaKslsoTs-pIpplhp-ANss-sCsGlIsWMHTFSPAKMWIpGLptLp..KPLLHLHTQaNp-IPWsoIDMDFMNLNQSAHGDREFGFIsuRhphpRKVVsGHWpDtcVpccIusWhRsAsuas-upplKVARFGD.NMRpVAVTEGDKVEAQIpFGaoVssaGlGDLVphlssVo-p-lcsLlpEYpspYslssshpp.ssppcpulpptA+lELGl+pFLc-GGasAFTTsFEDLtGh+QLPGLAsQRLMA-.GYGFGuEGDWKTAALlRhhKlMupGh...sGTSFMEDYTYchssGschlLGuHMLEVCPSIA	..............................................................................................................................MhhhcsYEVWFVlGSQHLYGsEs..L+QVs.pHAcclVsu.L.NspucL..P.sKlVhKPlsTosDEIosls+-ANYD-cCAGllsWhHTFSPAKMWIsGLshLp..KPLLphHTQFNsslPWDoI....D.......M...D......FMN....L.NQoAHG....s....R....EFGFIsARMRpp..+.tVVsG.H.W.p..D.cp.s.pc+IusWMRtA...luhp-o+pLK...VsRFGD...NMR.cVAVT-GDKVuAQI+FGaSVNsauVGDLV.p.lVsu..lSDuD.l.sALl-E.Ycs.pYshssusp.....p.G.-.++psVh-AARIELGh+RFLEpGGa.cAFT.TsF......E.....D....L.........a..........G.....L.....K..Q...L..P.G.....L..A...VQ.R.LMpp.GYGF..uGEGDWKTAALlRlMKVMusGL....p....GGTSFMEDYTYcFc.pG..N-hlLGSHMLEVCPSIA.................................................................	0	70	136	171
+1229	PF02311	AraC_binding		AraC-like ligand binding domain	Mian N, Bateman A	anon	Pfam-B_12588 (release 5.2)	Domain	This family represents the arabinose-binding and dimerisation  domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH)  DNA-binding motif Pfam:PF00165. This domain is distantly related to the Cupin domain Pfam:PF00190.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.58	0.71	-4.48	58	10833	2012-10-10 13:59:34	2003-04-07 12:59:11	14	20	2515	10	2189	13862	1372	132.60	12	46.69	CHANGED	hsshtthpsph.tpta.s..HhHs..tatlthltpGssph.phsspp.....aplssGclhllsPsp.Hphtsss.........pt..saphphlhhpsshltphhtphthht...................hhpsspltphlpplhptl............ppttsshhtpshlhpll	.....................................................ht..................h........HhH.s....th.p..l.h.h..s..h....pGs.s...p..h..t.h...s...s..pt......................ah..l.psGslh.h..l...s..s..s..p..h...H...p....h.t..sss............................................sh.p..h...h..h..l....h.h......p.......s...t..h.......h..............t...h...h...t...t...................................................................h.............h....hh...........................................................................................................................................................................................	0	712	1314	1755
+1230	PF03869	Arc		Arc-like DNA binding domain	Finn RD	anon	DOMO:DM07094;	Family	Arc repressor act by he cooperative binding of two Arc repressor dimers to a 21-base-pair operator site.  Each Arc dimer uses an antiparallel beta-sheet to recognise bases in the major groove [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.28	0.72	-4.34	3	753	2012-10-02 18:44:02	2003-04-07 12:59:11	9	3	491	41	123	550	31	46.50	30	53.16	CHANGED	uRcsP+FNlRhPcEVREpl+cVAEuNGRSMNSEIlQRVp-SLpKEGslsu	..............ph....lR.lPp..pl+-plcphAcpssRShNuE...l....lthLcpult.p......t...................	0	21	58	85
+1231	PF04659	Arch_fla_DE		Archaeal flagella protein 	Waterfield DI, Finn RD	anon	Pfam-B_4437 (release 7.5)	Family	Family of archaeal flaD and flaE proteins.  Conserved region found at N-terminus of flaE but towards the C-terminus of flaD [1]. 	20.80	20.80	20.80	21.50	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.47	0.72	-4.20	22	97	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	55	0	68	99	1	97.30	34	28.55	CHANGED	.cspcps+LcslP.--shu.hlshcWLEFLhp+sGhsshs-sL-YYhslGWlS-cshscLhcas+Ghph.p-p.....pssscLohsDHllSLLaIE+LsGcp	.........tppshLpplP.c-shuphlshcWLEFLlc+sGhpsh.csL-YYhslGWIS-cVhspLhcas+Ghch.t.c...............psstcLs....hpDHlhSLlaIp+LsG....................	0	8	36	56
+1232	PF01917	Arch_flagellin		Archaebacterial flagellin	Enright A, Ouzounis C, Bateman A	anon	Enright A & COG3354 & COG3353	Family	Members of this family are the proteins that form the flagella in archaebacteria.	29.30	29.30	29.40	29.40	29.10	29.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.30	0.71	-4.68	114	362	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	94	0	241	376	91	185.90	22	88.87	CHANGED	GtsG.luslIlFIAhVlVAAlsuuVllsoushlpppupssucpsspplsoslplhssss...........ssssssshs...........lslhlp.NsGus.slclspspls..lh.ss............................................................................................................................................................................................................................................................tlhshpssstshsss....................pssls.G-hstls..ls...............................................hssssphph.plhschGu.ssslph	............................u.sG.luolIlFIAhVlVAAlsA.uVllsoushlpppupssGcpusppluoslplhsssu...............................ssssss..s..lsp......................lslhl..p..ssG..us..sl...-lsps.plt....lssss..t.....ht.h..st..............................................................................................................................................................................................................................................................................................................t..thshhsl.pstssshtss.................shlp...u-...hhtlh.lsht....................................................................................................h.s.tp..thph.plhsp.Gssh.h....................................................................................................................	0	43	130	195
+1233	PF01637	Arch_ATPase	Archaeal_ATPase; 	Archaeal ATPase	Bateman A	anon	Pfam-B_1507 (release 4.1)	Family	This family contain a conserved P-loop motif that is involved in binding ATP. This family is almost exclusively found in archaebacteria and particularly in Methanococcus jannaschii that encodes sixteen members of this family.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.46	0.70	-4.66	56	1765	2012-10-05 12:31:08	2003-04-07 12:59:11	13	92	762	3	830	5495	1741	203.60	17	44.02	CHANGED	FhDREcELcclcchhccs.t.lhllYGPcssGKTuLL+phlpph..thsh....tslYhpshcphhttthcth........................tcpltcth...........................tpsl.psth...........phs.hsls.hhchlpccscc....lsllhDEl.phh..t.p................tstthlptLhphh-h..stphchhhl..lsuSS....-Glhhc..........lhGRppa.hplcsh.....hphhccsFcpl.....t....sc.ch.-clachsGGpPthLtpl	.......................................................................................................hhsRppE...l....p.........l.........p....h.....h.......p........p........t.........................p....h.....h...l...l...h.G..RchGKTs....L.l.....p..p..h...h....p...ph....................................hsla....h.........s...h......p....p....t..t....t....p.....p.....h.p..p..h............................................tp..h....p..hh...............................................................................................................t......h....t.........h..........................t.......h...t.s..h..p..p...h.h...p..h...l....t.p....p..tpt................hll....h...l.....D.Eh...p.lh........p.......................................................................t..h.......p...h.ltp....hh....pp.................p......p.....p......h...h...hl........h...s..G...S..t.........s..hh.p............h.t.....p.t....s......h.h...s......p..h....p....h...h.l.p...h....................h.phh.........t...................................t....h...........hht...hhsGhs......h...............................................................................................................................................................................................................................................	0	292	489	679
+1234	PF00798	Arena_glycoprot		Arenavirus glycoprotein	Bateman A	anon	Pfam-B_1047 (release 2.1)	Family	\N	25.00	25.00	28.70	28.60	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.84	0.70	-6.09	20	431	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	50	30	0	349	0	309.30	46	98.66	CHANGED	MGQlloFFQEIPpllpEAlNIALIsVSLlAIlKGllNlaKsGLhQLlhFLlLAGRSCS...h.......pIGc+pphpolplshoplh....tphPtsCplNNoHaYl+sspsop.Gl-lolTssolls.......ph..tthsNlosChcssptt.....asLpWllsslHash.pssphl.stspspssuthpIQhNLoc....tpcstpaspplhsultclFGshpts.........................C......stsshpaLI.IQNoTWp...........scCphs...Hhsol+lLhpsstpphl.oR+LhuFFoWoLSDSsGNDhPGGYCLE+WMLluucLKCFGNTAlAKCNhsHDSEFCDMLRLFDFNKNAIcoLpspocpplNLls+oINuLISDsLLMKN+L+ELMsIPYCNYTKFWYlNHTtoGcHSLP+CWLVpNGSYLNEocFRN-WlhESDpLIoEMLsKEYp-RQG+TPLuLVDlCFWSTlFYosolFLHLlGIPTHRHIlG-uCPKPHRLsppGlCuCGhYpp.sK	..MGQlloFFQElPphlpEshNIsLlAlSllAllKGlhNlhpsGlhtLlsFLhLsGRSCo.......h.......hhtthhEhQolphsMspL......shP..CphNsSHhYlphGpp....hplohos.oll......................pp.sslosshppp........aslh.hhsshthsh...s.h..shspshstG.h.lQhNloh....s..shp.stphtsthhphahthh.s...........................C.........s.sh.hlh.hpspsW.spC.hs....hsh.thl.tptt.....tRplhuhFoWsLoDstG.p.................................................................................................................................................................................................................................	0	0	0	0
+1235	PF00843	Arena_nucleocap		Arenavirus nucleocapsid protein	Bateman A	anon	Pfam-B_1333 (release 2.1)	Family	\N	22.70	22.70	22.80	33.30	21.70	22.60	hmmbuild  -o /dev/null HMM SEED	534	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.76	0.70	-6.62	17	468	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	52	24	0	392	0	313.20	54	96.85	CHANGED	ScpVPSFRWTQSLRRGLSsaTpsVKuDVl+DA+ullsuLDFspVupVQRlMRK-KRsDsDLs+LRDLNKEVDsLMpM+SsQ+sslLKVGsLo+DELM-LAoDL-KLKpKVhRsEt.ssssGVYhGNLTsoQLspRuclLchlGh....pt.pssssGVVRlWDVK.....Dso.lLsNQFGSMPALTIACMoc..QGuEshNDVVQuLT.sLGLlYTVKYPNLsDL-KLoppHssLplITp-cSuINISGYNhSLSAAVKAGAChlDGGNM.LETI+VpPssFoolIKslLpVKp+EuMFVu-sPGpRNPYENLLYKlCLSG-GWPYIuSRSQIpGRAWDNToVDLsscs.......ssspsPh+sGus.pLssLo.sQEt.l+cuhtpLDPssTTWlDIEGsssDPVElAlYQPsoGpYIHCYRcPpDtKuFKspSKaSHGlLlKDLtsAQP.GLlSslIctLPpsMVlTsQGSDDI+KLh-hHGR+DlKllDVchou-pARhFE-tVW-+FshLCcpHsGlVlpKKKKGss.s.o....pPHCALLDCIMFpuslsGt	......................................................................................................................................................................................................................................................................................................................................YIuSRopIhGRuW-NTsVDLss.c.s.......sssptP......pt.su.tshp........usLo.tQphhlK-.uhtpLDPssshWlDIEG.PsDPVElAlaQPsuupYIHhaRcPpD.KtFKpsS+aSHGI.lpDl.sApP.GLhShVIthLPpsMVlTsQGSDDIRKLhD.pGR+DlKLlDVcLop-puRpaEptVW-+atcLC+hHsGlVlpKKK+ttt....hp...................................	0	0	0	0
+1236	PF00025	Arf	arf; 	ADP-ribosylation factor family	Sonnhammer ELL	anon	Swissprot	Domain	Pfam combines a number of different Prosite families together	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.12	0.71	-5.03	20	5460	2012-10-05 12:31:08	2003-04-07 12:59:11	16	68	556	115	3415	26010	2506	161.80	36	79.30	CHANGED	hsslhupLhu....sKEhRILhLGLDsAGKTTILa+Lphs-lso...shPTlGFNlEolpa.....+Nl+FslWDlGGQcplRPhWRsYassTsulIaVVDSuD+-..RlsEu+pELpslLsE-ELp...sAslLlhANKQDLPsAhSssElpctLuLpp.......l+.....sRsWpl.sssAlpG-GLhEGh-WLussl	...........................................................................................h.......h.h......pc.c..h..+....l..l.h......l............G.LD..s.......A....G...K.......T.........T.....l.....L.......h.......p........L.....p.......h..........s........c.......h....s..p...................h.h....P.............T........l................G..........F.....N.....l......c......p.....l....p..h............................p...s......l........p.........h.......p...l..........W..............D....l.......G............G...........Q.........p.........p..........l............R.............s.........h..........W.............+...........p........Y........a.........p..........s.........s............p...........u...........l....l..........a..........V..........V................D..............S..........s..........D..........c.......c...................R......l............t........-............u.......+.......p........E.....L.....p.........p.......h.........L.............p...........c........c.........c.....L...p............................s..s.....s...l....L.....l....h..A..N.....K............Q.............D..l....s.....s.........A.............h.....s.....s......s......E........l.....p....c....t......L..s..L..p..p.................................lp...............p.R...t...h....h...l............s..s...s..A........h........p......G......p........G......l..........-.uh.cWL.p..h.............................................................................................................	0	1187	1801	2657
+1237	PF01316	Arg_repressor		Arginine repressor, DNA binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.06	0.72	-4.42	10	4229	2012-10-04 14:01:11	2003-04-07 12:59:11	16	5	2719	38	530	1777	256	69.40	34	44.70	CHANGED	hsKspRpptI+cIIppcclsoQsELlctLpcpGls.VTQATVSRDL+ElshVKVt..ssGphhYsLss-sph	..........................p+ppRh.p....hI+.pl.lpccc..lp...oQpEllptLpc.p.Ghp.lTQuTlS...R...D...l...+-.....l....s...llK.lt.stps.p.....hhY.sLssp...h...................	0	156	308	440
+1238	PF02863	Arg_repressor_C		Arginine repressor, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	25.00	25.00	30.40	29.50	21.60	18.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.18	0.72	-4.51	146	4296	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	2715	74	531	1750	261	69.90	29	45.54	CHANGED	hlpphllslctspshlVl+Th..PGsAphlAshlDph.phsc..IlGTlAGDDTlhlls+stpssppltpplpph	.................h.lpchllsl-hsst.hlVl+Th..PGs..Aphl.usllDp.........h..phcp.........IlGTlAG.D.DTlhlls.csspsupplhcplhp................	0	156	310	442
+1239	PF00491	Arginase	arginase; 	Arginase family	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.00	22.00	22.20	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-12.03	0.70	-5.11	347	5883	2012-10-01 22:40:15	2003-04-07 12:59:11	16	18	2993	272	1841	4658	4174	269.20	24	85.75	CHANGED	tclsll.GlPhDt...s.ssh.RsGs.chGPp......ulRpu.h.ht............hs...s................hplh....................................D......hGD.l........shs.............................p.tp.s...hcplpptspp.l.....lp..p.................uths......................lsLGGDHolohshlpuh...scth...................st..lullahDAHsDh.ps...............tsst..........hs.HGsshp...p..................................shp..hhlp.....tphhplGlRshsps....-...h.........t.h...cthGhp..hhshcclpphuh.t..th...hcphhptl.....t....t....slYlShDlDslD.PuhAPGoGTPts.G.Glohc-shtl.lct.l...ts.....hpl..lGhDlVEls.P....shD..s..................thTuhhAupllh..p.hhs	.....................................................................................................................................................................phsllGhPhDh.....h..sph..Rs.Gs.....c......h.GPp........ulRps.h.ht.................p...s....................................hplh..........................................D.......hGD.l..........shs....................................................h...s.t.p..h.........hpplpptspp.l..lp..p.....................sths.......................................lslG.GD..H.plshshlpuh....scph.....................................s..lullahD.AHs..Dhps...................................ss.t...........hs..HGoshtp................................shpp...shlps........pphlpl.GlRshsss.........ph.................................phh.....cctG..hp.......h.hs..h..p.c...l...p...c.h.......uh.....t...........tl...........hpplh.phl.....t.........sp.....slYlohDlDsLD.P.u.hA........P.G..s...........G.....T...P....s.......s........G...G.......l.o...c.c.s.h.pl.lct.l.....tp............hpl.....suhDlV.E....ls..P....shDt.s...................hTuhhuuplhhp...h...............................................................	0	557	1073	1504
+1240	PF00764	Arginosuc_synth		Arginosuccinate synthase	Bateman A	anon	Pfam-B_888 (release 2.1)	Family	This family contains a PP-loop motif [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.30	0.70	-5.42	12	4339	2012-10-02 18:00:56	2003-04-07 12:59:11	14	19	4054	37	1169	3498	3319	374.20	40	92.38	CHANGED	VLAYSGGLDTSVsIshLp-chs..EVlulslDlGQst--lctscp+AhchGshcphslDAK-EFsc-Yha.uIpANAhYEs.YPLuTALARPLIAK+lVEsAcccGApAVAHGCTGKGNDQlRFEsshtshsPplclIAPhR-hshT.....RcctIpYAcp+GIPlssshcpPaSIDcNlWGRulEuGhLEDPhstPPc-lataTpsPtcssppP-hVcIsFcpGVPVuls......Gcphss...lplIpphNElAGtpGVGRlDhlEDRllGlKSREhYEsPuAhlLlpAH.csLEslTLsR-.h+FKchl-pp.auELlYpGLWasPL+csLcAFIs+oQE+VTGhVRV+La+GshhlhGRcSshu.LYstcLsoa-.scshDQptupGFlphaGLpu+lap	...........................................lLAYSGGLDTSlhlhWLpcch....t-VlAh.su.........D..l....G..Q..s............-....-..h...-.s..l.c.c....KA.hphG...A...p..c....s..hl...lDs+cEF...sc.-a.lhssl.pus.A........h...Y....E....s....p....YhL.sTul.u....R.P...l...I...u......+tLVc.....hA+..cpGussluHGsTGKGN.D....................Q..................VRFEhshh.u.ls.PpLcllAPWR-hs.h.h.....uRc-hlp....aspppslsl.t...h...........s........h...c........p....sYShDpNlht.t..ohE.......u.t.LE..ss..h.....s.....p.....s....s....c.s....h.a......th.o.h.ss.-.p.s.ss...........p.s-.lplpF-p..GhPVul..N......................Gcp.h.ss......spllhcLNclu..G+HGlG.R.lDhlENRl..lGhKSRGl.......YEs..................PGuslLhtAH.ctLEs.lsls+-.shc.h+.c.t.l.tt.c.hucLl.Yp.........GhWFsP..p...p.hLp.s.hl.pc.....s.ppt.V.oGpVplc.......La+G.s.hh.lh.u.pcS.s...p.s...L.Y...stc..hsTa.p..c..s...c.....s..a.stpcAhGFIplhuL..p...t..........................................................................................	0	359	740	981
+1241	PF01960	ArgJ		ArgJ family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of the ArgJ family catalyse the first EC:2.3.1.1 and fifth steps EC:2.3.1.35 in arginine biosynthesis. 	25.00	25.00	34.00	28.60	21.50	16.80	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.42	0.70	-6.06	139	2527	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	2367	44	817	2155	2927	371.30	40	94.80	CHANGED	FpsuuspuGlK..................ps.+hDLullh..sp...tsussAGVFTpNphpAAPVhlsccpl.......pss.p....h+AlllNSGNANAsTGppGhpsAtphsphsAptLslss............p..........pVlluSTGVIGp.L.Ph-pltsulsp..hst.tL.........s........ts..shpsA...AcAIM.TTDThsKtsuh....phpls.Gp...plpluGlAK..GuGMIcPNM.......ATMLuFlsTDAslsssh.LpphLcpulcpSFNpIoVDGDTSTNDolllhAsG..tu.ss............s.lsp...ts.t...hptFppuLptVstcLActIs+DGEGATKhlplpVpGAtscp-AcplA+ulusSsLVKTAlaGpDsNWGRIlsAlG.hu.....Gs...sh-ssclslhl.........s....s.............lhlhpsGthss.as.E..ppupphhpp.........p.-lpIpl-L.....st.Gs..upussWsCDLoa-YV+INA-Y..RT	...................................apsuuhpAGlK..................ss...+tDlullhss....ss..u.s.s.A.uVFT.pNphpAAPVhhs+ppl.......ssu..p.........hp...AlllNSGsANAs.T.........G........tp..Ghpcupphspts...Aptl...s..ht..s.............p...............pVhlsST....GVIG..p...LPh..-.+lhs.ul.sp..hh.s.sh...............tts........shtsAAcAIh...TTDThsKtssh.....p.h.p.....l.....s.....Gp.................slsluGhAK..GuGMIpPNM...................ATMLuF............lsTDAsls.....s.sh.LpphLppsscpoFNpIoVD...GDTSTNDslllhAs.Gtu...st............................................lpt.......tp.p......httFppALptVspp.....LAptls+DGEGATKhlpVpVpGAt.opp-AcplA+slspSsLVKTAla.GpDsN.W..GR.IlsAlGhu................us...........shD.s.splslhl......................ss......l.lscpGt.ss.....as...E....ptspthhpp...........................................c.-lpIplcL..........sh...G...s........u.p.ussWsCDLoa-YVcINusYRo...............................	0	273	556	708
+1242	PF03308	ArgK		ArgK protein	Mifsud W	anon	Pfam-B_3540 (release 6.5)	Family	The ArgK protein acts as an ATPase enzyme and as a kinase, and phosphorylates periplasmic binding proteins involved in the LAO (lysine, arginine, ornithine)/AO transport systems.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.69	0.70	-5.62	9	1738	2012-10-05 12:31:08	2003-04-07 12:59:11	11	13	1333	12	625	2137	1076	266.50	40	60.95	CHANGED	LARAITLVEsccs....pAppLLcclhPhsGpAphlGlTGsPGuGKSTLl-tLhtpLtccGh+VAVlAVDPoSPhTGGuILGD+hRMpchu......scsGsFIRshsopGsLGGluptTp-sltLh-AhGaDVlllETVGVGQSEV-lsphsDshlllplPGsGD-lQuIKtGlMElADlhVVNKAD...htsActstp-LphALcL.p......................c..ctsWpPPllcssAspGcGlcELW-tIc-H+chlptoGhhtp+RRppttc.hhpllpstlhs+lpuu.s	........................................................................................LA+AITLlES..pp.stc....................hu.p..pl..L...p...t.....l.......h........P...........t..........s..........G....p.........u......h.........R..l...G.I.T.Gs.PGAGKSThl-ulGh.t..L..........h...c..c...G...t...+..VAVLA.....VD......P..S......S...s......hoG.....G......SI...L......G....D.+T...R...Ms.cLu...................................p.c......s..uF.....IR..P...s.s...o...pG.....p.....L....G.....G...l.up.....t....s.....+E.....shh.lh.E.A.A.......G.....aDll....lVET.VG...VG.Q...SEs...s.V.sphsD...shl.hl......h......lsusG......DpL.Q................u...I.K....+....G.l..h....El...AD......l...ll.lNKuDh.....pps.Apt.u..t..p.-....h.p.s.u.L...+...lhpt..................................................................................p....tstWp.P...VlssS..A..h....p.....t........c..Gls-lW...pt.l..c..apph.h..pt....s...G...thp..t..pR....p..pQ.t.htahhp.hpptlhpph....s...................................................................................................................	0	245	446	556
+1244	PF02374	ArsA_ATPase		Anion-transporting ATPase	Mian N, Bateman A	anon	Pfam-B_1201 (release 5.2)	Family	This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell. 	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.70	0.70	-5.38	11	2686	2012-10-05 12:31:08	2003-04-07 12:59:11	10	13	1221	72	1090	14632	4072	239.70	25	76.97	CHANGED	h+alFhuGKGGVGKTTsSsATAlp..Luc.G++sLllSTDPAHsLSDuFsp......chG+pPTKlp..-NLhuhEIDPp........hplpchhtpshc.hsssh...thphlpshlp-thsu.PGh-EhhuFsphh+ahc......sscaDlllFDTAPTGHTLRLLphPsshsphhc+hhchpp.....ltshhp.h.t...hGusshs....chhppl-pphEplcthp-hloDPspToFhhVshsEchSlhEocRshptLtpaGlcscslIVNp.llPEsspp....spahpu++plQpKaLcpI--hFpshslsclPLhppEltGlcsLpchuphLhs	...........................................................hl.hh.s.G..KGGVGKT..Th............us..u.h.Alt...........h...A...p...........t...G.......c.......c..ll.l..l.............o.o..D.............P.....A....p..s.......L..........u.........p...s..h...s......................................p..h..s..t..p...........h.........l..........t....................................s...........s........L..........s...........h....p...l..D.sp......................tt.h..p.c...h..h....t...p...h.....h.....t............h.....t...t.....h.........................t.....h........s....h.....h.....p....c.......t..h.....s.....u...............P...s.........h....p........E.....h....h.....s....h..t.........p....h..t..c.hhp.........................ptpa...-...h...llhDoAP...T.G..........c..TLc...h..Ls......h..P...p.th.........p...t..h..l.......t.........t...............t...............................................................................................................h..t.t..h.t.t.....................t....h..........t........t...........h............t..........hts...........t...........othhh.V..h.sp..s..l.Es.ph.t..Lt........t..h..t.ll..lNt...h..h............................................................................................................................t.....................................................................................................................................................................................................................................	0	393	721	952
+1245	PF02040	ArsB		Arsenical pump membrane protein	Mian N, Bateman A	anon	IPR000802	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.53	0.70	-5.52	4	1841	2012-10-02 15:12:49	2003-04-07 12:59:11	10	4	1464	0	343	2231	187	367.80	44	95.11	CHANGED	LAhsIFLLTLVLVIWQPKGLuIGWSAslGAVLALIsGVVshuDl.sVhsIVWNAThTFlAVIlISLlLDEhGFFEWAALHhu+.hupGpGh+hFsalsLLGAhVAALFANDGAALILTPIVlAMlhALtFsctsshsFlhAuGFIADTsSLPLlVSNLVNIVSADYFslGFhEYAShMlssslhSllASllVLaLaFRKsIP.sYsLppLKsPtpAIKD.shF+luWhlLhlLLlGaFs.E.luIPVSslAushAlIhlhlAp+u+AlpTt+Vl+tAPWpIVlFSlGMYLVVYGL+NAGLT-lLuslLsshu-pGLaAushGhGFluAhLSSIMNNMPTVLlsALuIsuSsssGhl+EAMIYANVIGsDLGPKITPIGSLATLLWLHVLopKGM+IoWGhYF+TGIllTlPVLhlTLsuLhLpL	...........................................................................................hAhhlFlhT.l.l....h..l....l...W..p....P......+......G.....L.s...l.........u...h..s..A..h..h.G...A....h...l......s.l....l....h...G.l....V...p..h..s...D...l................V......h....s..........l........V.......W...s.A....o.h..s...F...l.u.l.I.lI.Sl.lLD...c....G.F.F.-....W..u..A...l+.h.s.+.......h...up.....G...p.....G..h.tLF.sal.h...LLG.AhVuAhFANDGAAL.ILTPIVlAhl...h..sLs.a..........s.p......t.s.h.......h...s.......Flh.A.u...GF..I..A.D.......o....u....S....L....P...Ll..V.S..N..L.V...N.I..l..o....A.....c....a.....F....s....l..u.F..h..c.Ys......u.....h......M.h........s..s.l.h.....u...l....l...A..o...l..l.....h...L...a...l.....a......F.........R....+.......s.....l....P....p...p...........a.....-.....h......t...............l..........p.........p.....P..t........p.........A......l...p.............D...................t.......h.....F......+.....h..u.....h.h.l..L...h......l.L.......L......h....G......a......h............l...h....E.......l........s........l...........P................l.........S..h......l....A...s..l....s....A....h.......l....h....h......h.......l.......A..t......+......u......p.....s......l.............s........s....t..........p..........ll.+..s..A...PWpIVl..FSlGMYlV.VaG.L+N..s.G..l....T....p....hLu....t.....l....L....p....h.....l.....u......p.....t......G.......l....h.s...uh....h....G..hG...h.l.....s...A.h.LSul..h.NNh..P.....s.....V...............L............l........s........s.....l.........u.........l...s.......t........s.....s..........s.....s....s.....h....h..p.....c.......u...........h......l....Y..A.N.l....I...GsDLGP.K.....lT.P.I.G.SLATLLWL+..V...L.sp....K....s........h...p..I.o..Wu........Y...h...+s.G.l.l...h.T.l.P.l.Lhh.T.LhuLhh....................................................................................................	0	93	207	283
+1246	PF03960	ArsC		ArsC family	Bateman A	anon	COG1393	Family	This family is related to glutaredoxins Pfam:PF00462.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.33	0.72	-3.99	36	7591	2012-10-03 14:45:55	2003-04-07 12:59:11	10	18	3508	24	1253	4303	1099	107.40	26	86.65	CHANGED	YtsssCsos+KAhpaLcppslpaphhshhpsshscccLppllpphs.s.hcpllsp+upsa+pLs.....ls.pplot.scllcllhcpPpLl+RPIlhss......c+lplGass-plpth	......................Yt.PsCsos++A.h....p....h...L....c....p...........p....s....l..p.h.p.h.hph.h..p..ps...o..tcpLppllpph.......u.....s....hcpll..ss+u.p.ha+cLs.......hp...ss.l.ot..pp..h..l.plhhppP.tL.l+RP.Il.lss...........pp.h.p.l.Gasp-phtt.........................................	1	315	718	1014
+1247	PF01129	ART		NAD:arginine ADP-ribosyltransferase	Finn RD, Bateman A	anon	Prosite	Family	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.53	0.70	-5.25	9	454	2012-10-01 23:25:29	2003-04-07 12:59:11	13	17	114	8	209	503	14	201.40	31	63.26	CHANGED	LDMAssoFDDQYtGChccMct+.hPpL.+pEFstspthsssWcpAppcWp..........cR......psphs...........hPhsF+DpHGlALlAYTus....s.la+.FNpAlRpuGtS+pcYhtpFpFKslHFhLTcALQLLps....tsCpp.....VaRGl+.....GhRFp.st.GtoVRhGpFsSoSLp+psAp.....FGpsThFslcTChGssI+saShaPpE-EVLIPPaEsFpVsshpp.spu.spI.LcShs+pso	..................................................................................................shs.ssFDD...pY.sCtpp.h.tt..hs.p..h..hppEhttpp.htpsWppA..p.tWt.....................pp...........ttth............hP...s.h.pspau.l...AlhsYTss.....sslappFNpAl+....psutohp.pY.h.p.p...F...p..FKslHahLTpAlQlLpp.............thChp........V.a.RG..sp.............s....h.p..F....p......s..t...hG....t.p.lRhG....pFs...SoS...hpct.Ap................pF....G....p......p..........T......h...F......sl...h......T....C....h........G.......ss.......l...pta.S.hh...t.E..cEVLIPPhEhFpVhpht....ptt.ts.....l..L.t.tp.............................	0	25	49	112
+1248	PF02497	Arteri_GP4	Art_glycop; 	Arterivirus glycoprotein	Mian N, Bateman A	anon	Pfam-B_787 (release 5.4)	Family	This is a family of structural glycoproteins from arterivirus that corresponds to open reading frame 4 (ORF4) of the virus.	20.70	20.70	24.20	24.10	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.28	0.71	-4.35	3	241	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	9	0	0	248	0	176.90	80	99.36	CHANGED	MAuoLLFlLVGFcClLVSQAFACKPCFSouLSDIcTNTTAAAuFhVLQDIuCaR.HRsSAu.EtIp..KsPQCRTAIGTPpYVTITANVTDEuYLHsADLLMLSACLFYASEMSEKGFKVlFGNVSGlVAVCVNFT-YVuHVpp+TQ+.pLVlDHlRLLHFLTPSsMRWATVIACLFAILLAI	............................................................................MAAuhLFLLVGFcChlVSQAFACKPCFSSSLSDIKTNTTAAuGFsVLQDISCLR..HGsS...uS.......sIR...KsSQCRTAIGT..PVYITITANVTDENYLHSSDLLMLSSCLFYASEMSEKGFKVVFGNVSGIVAVCVNFTSYVQHVKEFTQR.SLVVDHV.RLLHFMTPETMRWATVLACL.FAILLAI.	0	0	0	0
+1249	PF01481	Arteri_nucleo	Arte_nucleocap;	Arterivirus nucleocapsid protein	Bateman A	anon	Prodom_2418 (release 99.1)	Family	\N	20.40	20.40	20.60	22.90	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.37	0.71	-4.00	4	700	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	11	6	0	662	0	110.20	70	93.69	CHANGED	SQpK+Kp....GNGpssN.QLsQhLuthl.tpttQs+....Gptp+KKpPtKP.HFPlAs.sDlRHchT.sERphChSSlQThFNQGuGosoLuDSGtlsaTVpF.LPTppTVRLIpsoAss	...................pQpK+Kp....GsGQPVN.QLCQhLG+hI.uQppQsR.....G....p....psKKKp......PEKP.HFPLAsEDDVRHHhT.oERpLCLpSIQTAFNQGAGTsoLSsSG+lSapVEF.LPstHTVRLIRVTuos...............	0	0	0	0
+1250	PF01606	Arteri_env		Arterivirus envelope protein	Bashton M, Bateman A	anon	Pfam-B_664 (release 4.1)	Family	This family consists of viral envelope proteins from the arterivirus genus; this includes porcine reproductive and  respiratory virus (PRRSV) envelope protein GP3 and lactate  dehydrogenase elevating virus (LDV) structural glycoprotein. Arteriviruses consists of positive ssRNA and do not have a DNA stage.	21.20	21.20	21.70	256.50	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.67	0.70	-4.68	3	333	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	8	0	0	354	1	211.30	78	82.56	CHANGED	MAcpCshFHhFL.CuFICYSsCCAVsANSoA..ThCFWFPLs+.GNTSFELolNYTlChhCsTsQAAtphLEPG+shWCRIGHDRCEEsDHDELsFslPsGhp.Lp.EGa.TSlYAWLAFLSFSYAAQFHPElFGIGNVSpVaVDh+HQFICA.HsG.NSTLscH.+NISAlaAlYYpHQlDGGNWFHLEWLRPLFSSWLVLNVSWFLRRSPAS+VSRRl	...MAsSCsaLHIFLpCuFL.YoFCsAVVANSNu..TaCFWFPLVR.GNFSFELsVNYTVCPPC.TRQAAuphLEPGRShWCRIGHDRCpEsDHDELGFhlPPG...LSSEGHLTSVYAWLAFLSFSYTAQFHPEIFGIGNVScVYVDIKHQFICA.HDGpNuTLPRH.DNISAVFQTYYQHQVDGGNWFHLEWLRPFFSSWLVLNVSWFLRRSPAS+VSVRV.	0	0	0	0
+1251	PF00951	Arteri_Gl	Arteri_glycop; 	Arterivirus GL envelope glycoprotein	Finn RD, Bateman A	anon	Pfam-B_425 (release 3.0)	Family	Arteriviruses encode 4 envelope proteins, Gl, Gs, M and N. Gl   envelope protein, is encoded in ORF5, and is 30- 45 kDa in size. Gl is heterogenously glycosylated with N-acetyllactosamine in  a cell-type-specific manner. The Gl glycoprotein expresses the  neutralisation determinants.	21.80	21.80	22.90	24.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.97	0.71	-4.68	11	8906	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	12	0	0	8965	0	171.80	75	86.54	CHANGED	.u.uhss.sss..p..p.h.ap.hhpphssTthhpphhsaulpohslh.hsp+lhphthLshsphl.hlshusl.uhhsahthchshossYuhsAlsALla....Flhp....ss..+.ChstRhhhst.ssFl.sscG+..lapscosl.lVc+sGpstVsGcLV.slKplVLsGpKAs.hstssAcpWp	.............hss...hsNAsss.S.SSHhQ.LIYNLTLCELNGTDWLs.s.+.FDWAVETFVIFPVLTHIVSYGALTTSHFLDTVGLlTV.STAGFhHGRYVLSSIYAVCALAALlC....FVIR....hA..KNCMSWRYSCTRYTNFLLDTKGR..LYRWRSPV.IIEKGGKVEVEGHLI.DL.KRVVLDGSsATPlTRVSAEQW.G................................	0	0	0	0
+1252	PF01097	Defensin_2	Defensin; Arthro_defensin; 	Arthropod defensin	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.12	0.72	-4.23	15	314	2012-10-01 23:31:40	2003-04-07 12:59:11	13	1	158	14	58	362	0	33.90	42	40.60	CHANGED	u.hh.lNcoACAtHCls+.G.p+GGYCsu..KsVClCR	............hhsh..spusCsuHChuh..G.p+GGYCss...ptlCsCh.............	0	23	27	51
+1253	PF04161	Arv1		Arv1-like family 	Wood V, Finn RD	anon	Pfam-B_9351 (release 7.3);	Family	Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis [1].	20.00	20.00	20.30	21.50	18.20	19.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.82	0.70	-4.42	21	319	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	253	\N	217	304	3	176.80	27	62.27	CHANGED	hlCIpCspt.lpsLYppY...Ssshl+LTpCspCp.cssDKYlEaDsVllaIDll.LLKspAYRHLlaN.h......................................scacphh+lhllhlLhEsY...........LhWtppccp.pps..............................h.h..hhp.tshhhQhlhFhhthll....phhhhhhhhthhhhthhphs......................ht.thphlhhslLlSthuKlF.ILhlIWsas.shhuhtllpllshhphlpuL	........................hClpCsp..sppLappY...............s.t.......t.s.......l+lo.CtpCp.phs......DKYlEaD.lllhIDll.LhKspsYRHlLaN.......................................................t...p..hh+.lhlh.hl.L...h-.sY............lpWh.p.ppp.t.s..................................................hhp.....h.thhhh.h.hh..shh....ts.hhh....h.h.hht...hhhh...hh.h............................................t....l.hslhlu.......hKlh..l..h...h.lW.hs........hthhh...............................................................................................................................................................................	1	62	112	171
+1254	PF01731	Arylesterase		Arylesterase	Bashton M, Bateman A, Fenech M	anon	Pfam-B_2101 (release 4.1)	Family	This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity [1]. Human arylesterase (PON1) Swiss:P27169 is associated with HDL and may protect against LDL oxidation [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.71	0.72	-4.00	6	216	2012-10-05 17:30:42	2003-04-07 12:59:11	15	7	94	0	130	450	101	84.20	42	23.51	CHANGED	NDIsAVGP-pFYuTNDHYFscsaLhhLEhhLshtWosVVYYSPsEV+sVApGFsuANGIslSsDcKalYVA-lls+sIHlhcKHss	...................................NDIlAVGPcpFYATND..H.YF...ss...s...h...L..p..hl.E.h.a.L.s..L..t.......Wus.VVY...Y...S.......P...p....E......V...+...l...V...Ac...G...a...s.ANGIs......lSsD...p....K...alYVA-..lhs+pl+Vhc+p..........................................................	0	37	50	79
+1255	PF00858	ASC		Amiloride-sensitive sodium channel	Bateman A	anon	Pfam-B_415 (release 3.0)	Family	\N	23.00	23.00	23.10	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.65	0.70	-5.83	114	2052	2009-01-15 18:05:59	2003-04-07 12:59:11	19	39	116	15	1489	1878	5	339.30	17	78.79	CHANGED	FspsoolHGhpal..h.sspt..........hhc......................R.....................hhWhlhhlsulshhhh.hhphhppah.spPslssls..hht..pls.FPAVTlCshN.h.......chst..lpt....h.........tt.hthht.hh...t.................................................................................................................................................................................................................................................t.............................phshhphhpph........uhsh.c-hl....hpCpapup..........h..spp......ahp.......................................................................................................................................................................................h..h....hTp.hGh.CYoFNsttt...............................................................hps....ttsGhpsGLplhLph......p..pp-hh..sttss...............................................................................h....Gh+lhlHsts-hPhhsp........shtlssuh..p.shlulp.pphp.......pls.............sshpp.Ch.ss.....p..........h.h.....ttY.ohssChhcChsphhlcpCsCs.hhh................................tphsh..........Csh..pp...h.pC..........hpphhtphh......................tC..p.C.ssCsphpYs...hphohsphsspt...h......................t.p.s.t..ppshthlplaa...cphsa.pphccp.sashssLL...............................uslGG.hGLFhGsSlLollEllhah	.......................................................................................................................................................................................................................................................................................thtu...hh....t.....................................p...............................hhWhhhhhh....hhhh....hh....h.......h...............h................a....p..................h.................hthp..........................................ph...F.Pu.lo....lC.s..s.....h.......p.p.......ht..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ph.ph.h...th..........................t...h..t.p..h.h.....h.C........a...t..t..............h.......pp..........h................................................................................................................................................................................................s....G....C.hshN.................................................................................................................h..........su..t...............G...l..phhl.t.h...........t....p.p....h........................................................................................................Ghp.l.l...at.........tp..s......t..t.............hh.......h.......s........t.s..h......t.hp....h............................h...............h.tp....Ch.tt..............................................Y....o..t....sC..hpC..p...h..h..p.....C.tCh....h......................................t...............C.s......tp..............h..C..........h.........h...................................................................C..........C...sCp...................a.t.......h.t.h.t.......h......................................................................................t..t.t..h..hlplhhtt......h....h..pt..hth.thh.......................................................................................sshGu.hulhhGhShlshhEhh....................................................................................................................................................................................................................	0	637	750	1219
+1256	PF01671	ASFV_360		African swine fever virus multigene family 360 protein	Bashton M, Bateman A	anon	Pfam-B_1174 (release 4.1)	Family	The multigene family 360 protein are found within the African swine fever virus (ASF) genome which consist of dsDNA and has similar structural features to the poxyviruses [3]. The biological function of this family is not known [3]. Although Swiss:Q65137 is a major structural protein [1].	22.50	22.50	26.90	26.20	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.46	0.70	-4.95	14	126	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	11	0	0	100	0	205.90	43	60.99	CHANGED	EpT+cLCccLGAKptLpcpclhphFhc.lpcpKTuuNlILCHElFssN.PlLcsls.tcl+hhIahcLctl...h..hhsphohsphLsKYWYuhAlcasLpcAIpYFYQ+asHlppWRLhCALhaNNlFDLH-lYpp-+lcMDhsEMMplAC.h+DpNahTIYY.CalLGAsINpAMlsSlp.aN.................hsNlFFCIDLGAssFEEuhtlAtpcshphlhplLs	............cpT+cLCccLGAKptL.pcpclhphFhp.lpcpKTSsslILCHElFssN.PlLpsls.hch+hhIhhpLcth...h..hhsphohsphLsKaWYuhAlcasLpcAIpYFhp+atHhppWRLhCALhaNNlaDLH-hYppcclcMDhs-MMplAC.hpDtNahTIYY.CF.hLGAsINpAMhsSlp.as.....................hsNlFFCIDLGAssF-EuhtlAtpp.s.phlhphL.............	0	0	0	0
+1257	PF05170	AsmA		AsmA family	Bateman A	anon	COG2982	Family	The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli [2]. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant [1]. AsmA may have a role in LPS biogenesis [1].	29.80	29.80	29.90	29.90	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	604	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.67	0.70	-5.90	12	3636	2012-10-03 05:41:17	2003-04-07 12:59:11	9	19	1503	0	623	2962	466	400.20	19	70.17	CHANGED	M+phh+hlhhlLlsLllll....hulhhhhssp.hpsplpp.Vuttsshplshcus.t............chhhP..plpLpslplussst.t.......hsplcplclsLushsLhspplplsplhLcssslpLsh.spsphshst.lp.pp.shss.............................ss.ph.luplplssuplhhpscstpphh..phslphpssslht...................................hshspstlsGphcpctpsh.s.lsssh.spsshst.thpst.t.......................hhtthuss.hphsshclhssplth.sshhhpsh..phsh.shpLphssht...s..thpt..th..htt.hh.sthsh..sPtslsltphstpaptupspsshth.p.th.h.............................................cptulsGht.ss.ssh.......h.pshPphp.pLphppLslschh.lpts.........pps.hptsshsstsssh.Lspcph.hshWps..............slp..hssspssa.spl.lscsthphpspsGhlpLsplpuslttGhlpusuplshsphstphplphsucsl.lp.Lhpth...hslpG.hslshshpGtutssshlhtslsGplchshssuthp...............................tt..tst.h.hph.phshshppGhlohs.h	............................................................................................................................................................................................................................................................................................hhhphhh.h...h...h...hsh..l.h.hl.........hhlh....h.h.h...p........p....h.p.sh.h.sp.........l...ptp..s.h..ht...h...p.u....t..................hth...h..P.......plhh..t.ph.....tl.....s.t........s.......t..........t.................hlphpphch.sls...hs.L.h....s....p....p....l.l.plhL.....ptsshp..L........p..t....s.....t........s...............h....t........p..p......t...ss..........................................................................t.................p.......h.....p.......l...s..t.h.h.s.....tuhl..h.p......p......s..p.........................p.h.p..h.......s........................................................................................................................................................................t.h...h.....t.........t.......h..p.........................................................h.......h.........th.........................................................................................................................................................................................................................................................................................................................................t............h.............................................................................................................................................................................................................t......t.ht.u......hh...t..............................................s...h.....pl.......hphtt............................................t..............................................................h....t..................ht.........................................ph...hphtt.h..h......t.h....h..pp....hth..p.......t.s.....htlp..hph..h...tG.ht......h..t...h.......p...................p...........................h..t..h..p.th..p..th........h.....t..................l..........................................................................G.....h.sh...h.phpu.....s.....hh...p.tGphth..ttt........................................................................................................................................................................................................................................................................................................................................................................................................................................	0	138	316	463
+1258	PF00733	Asn_synthase		Asparagine synthase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_443 (release 2.1)	Domain	This family is always found associated with Pfam:PF00310. Members of this family catalyse the conversion of aspartate to asparagine.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.71	0.70	-4.89	104	5876	2012-10-02 18:00:56	2003-04-07 12:59:11	16	41	3139	38	2130	12423	8100	248.10	24	44.92	CHANGED	plcchLpcuVppphh............uDlslGshLSGGlDSShlsulspc...........................................ts.lpoFoluapsss.................................................-hthActsApplusc..Hpphhlstp..-hhsh..l.cllhth-pPhs.....sshshshahhu+ts+...................ptspVsLSGcGuDElF..uGY....thhpps.thttht..hht.hpthhhh.h......................................................................................t......hh..hthh.st.L.t+sD+hsMutulEsRsPFLDccll-hshp.lPsphKh.psstt................................KhlLRcsh........pphlPcplhp.........RtK	...........................................................................................t.hpphl.ppuV...p..p..p.hh.....................uD..l..s..l.G.....s.h.L..S.G.GlDSS..l..l.s.u.l.s.pc...................................................................ht.......p..l....c..o.....F..s...l....u..h...p.s..s..s.........................................................................................-h.t.h..A..c..p.l....A..p.t..lGsp........Hpph....h......h..s..........p.................-.h...hpt.......l.p.h...l..h.t..h...-...p..s.....................tssh..s.h..a.h....h..s.c..hhp.....................................................................................tth.ph...s...L.SG-G...u....D....El..F...........u...GY...............................h.....h.t....p..t..........h...t......h.....t............h.....t...h...t.h....h.............................................................................................................................................................................h+s..s.+..h..........hu.h...u....l..........E....sR..s....PFL....Dp.chh.chs.hp....l.s.p..K..h...t.t.stt...............................................KhlLR.psh........................pt...h.l.P.t.p.lh.R.K......................................................................................................................................................................................................................................................................	0	735	1406	1834
+1259	PF03590	AsnA		Aspartate-ammonia ligase	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.80	21.80	21.90	24.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.47	0.70	-4.94	6	1603	2012-10-02 14:22:40	2003-04-07 12:59:11	10	4	1542	4	211	863	13	236.20	56	72.62	CHANGED	KoFIhQ.QppISFlKNTFTppLtE+LGllEVQGPILSpVGsGhQDNLSGtEKAVpVpVKpIPDAsFEVVHSLAKWKRHTLARasFupsEGLFVHMpALRPDEDsLDtsHSVYVDQWDWEKVIssGcRNluYLK-TVcpIYuAIRhTElAVsp+F.sltshLPcpIsFVHSEELVcRYPcLssKcREsAICKEaGAVFLIGIGGcLSDGKPHDlRAPDYDDWTT.SEstYKGLNGDILVWNslLscA	.....................l.p.Qpt..IsaVKspFpppLpccLsLlcVpAPlhscsGsGhpDNLs..GsE+sVphcVKs...l.P..D.u...p...hE..VVHSLAKWKRhTLucasFstGEGLYTcMpAlR.DEDp....LsslHSlYVDQWDWE+Vls.c.s..cRs..hshLKpTVcpIYtuI+tTE..........t........tV.ptca...s...l........t....s...h.....LP...-.pIpFlHSpELlsRYPDL.s.sKpREpAIsKE.hGAVFLlGIGGcL.s.DG+..HDsRAPDYDDWoo..................st...........u..........h.................GLNGDILVWNslLppA.......................	0	102	148	179
+1260	PF00026	Asp	asp; 	Eukaryotic aspartyl protease	Eddy SR, Griffiths-Jones SR, Finn RD	anon	Overington enriched	Family	Aspartyl (acid) proteases include pepsins, cathepsins, and renins.  Two-domain structure, probably arising from ancestral duplication.  This family does not include the retroviral nor retrotransposon proteases (Pfam:PF00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null --hand HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.08	0.70	-5.19	23	4762	2012-10-02 15:32:34	2003-04-07 12:59:11	18	56	583	656	3018	6175	72	282.30	24	71.72	CHANGED	pYhupIsIGTPsQpFsVlFDTGSSsLWVP...SspCsss........................uCpp+spacPSpSSTapps.Gps...a.sIpYGsGS.hsGhlupDTVslGGlslssQtFu.usp...su..h.....htuhhDGILGluasulssst...........hssVasslhsQullspslFSlYLspss....ttsGpllFGGlDsu+YoGslpalsVo..........ppsaWplslculsluss......shsssssp..............AllDTGToLlhhPsshlspltpslGAp.sp.................................................................................................t.....GtYslsCsshsphPslsFhls.Gtpaslssssalhpsssss..........ChhGhps......sssshaILGDlFlRphYsVFD.hsNsclGhAts	...................................................................................................................................Yhstltl....G...o......P..........s.....Q......p.h...p.lhh..D.T..GS.u...s.hW....Vs..........s......s..........................................................................................................s...............p.....t.....h.....a....s......s...p........t...S....s........o..h......p...........................s.....p.t............................h...pl...p......Y......u....s..........G..........s.......h......p........G........h......h..........s.......p.......D.............s..........l.............p...............l...............u..................s....................h..........s.........l...........p..........p............t.......t..........h.........u.........s......p..p.................s..........h.........................s.....h...s...G....l....l.Gl..u......a..s...p..h....s.sst..................................................h.shh..t..s.h....h..p..........p.....t.....h...l....s....p....s....h....F....u.....h.....h.........L.........s....p....ts.....................s.....G.....t...l..h...h.....G.....u......h...............D.....t....s......h..........a......p..........G..........p......l....t...a...h...s...l............................pt..s.h..a...p......l...p.....h.s...s.......l.....t..l...s..sp...........hh.s...t...t.....s....h.t...........................................................................sl....l..D....oG......T..o..h..........h.h..........h..P....p....p....h....h....p....t....l.........p...t....l....s..u.t........................................................................................................................................................................s..h.h..l..s..C.....s......t.......h......................h........s.......s....l...........s.....h..........t........h..........s...........s..........h...........p........h..s.....l........s.....s.......p......p.....h.....h.......h.....p.............t...t....t...................................C..h............s.h.s.........................................................t.......s........s.....h.........h.....l.......LG.s.s.F....lpp.h.as..l.a..D....h...t....p....t....p..luhA.............................................................................................................................................................................................................................	0	1115	1670	2449
+1261	PF02261	Asp_decarbox		Aspartate decarboxylase	Mian N, Bateman A	anon	Pfam-B_3879 (release 5.2)	Domain	Decarboxylation of aspartate is the major route of beta-alanine  production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	25.00	25.00	29.00	30.30	22.50	19.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.33	0.71	-4.51	163	2477	2012-10-02 17:45:13	2003-04-07 12:59:11	11	4	2416	51	550	1458	373	115.10	52	89.57	CHANGED	MhhphLKuKIHRAoVTpA-LpY.GSlTIDp-Ll-AAsIl.hEpVpIhNlsNGpRFpTYsItG-+GSGhIslNGAAARhspsGDhlIIhuYuthscpEh.cs.acPplVhlD.cpNplhc	...........MhpTMLpuKIHRApVTcA-LpY.GSloIDpDLL-AAsIlpsEpVpIhNlsNGpRFpTYsIsGE...RGSGlIslNGAAARhspsGDlVIIhoYuphs.-.-Es..+s..acPcVlah-.t.s.Nchh.c.........	0	193	390	489
+1262	PF00710	Asparaginase		Asparaginase	Bateman A	anon	Pfam-B_652 (release 2.1)	Domain	\N	22.50	22.50	22.60	22.80	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.03	0.70	-5.56	157	5341	2009-09-16 23:30:57	2003-04-07 12:59:11	15	27	3806	135	1165	3548	565	305.20	30	90.15	CHANGED	clh.......llsTGGTI...........uh.ttsspstthss.......ssptll...ptls....lpph...s.plps...............................................................................................................................................................................cthhs.lsSsshssppWhplupplppth...cs...cGhVlsHGTDThp.TAhhLshhl.ps.s....+PVVlTGu.+sh..........sphsuDu.tNLhsAltlAss............htGVhlshssc.......lhpupcspKsposshsA.F.pSsshsslu.hl...ss..plphhtp.hh.....................................t......................th...h.tthtsp.VsllthasGh.ss....phlcshl..ss.hcGlVlpuhGsGs......sssshhsslpcss.pp.G.......lsVVhsopshpGtVs...hshhusutplt.p...h.GslsusshssppAhltLhhhLupt..hshpcl.p	..........................................................................lhlltTGGTI........................uh..tt.s.s...p.s.....hhs.................tspsll......ptl.s......lp.ph.....s...pl.cs...............................................................................................................................................................................c..p.h...h.p...l.s.SscMss.ppWhplucp..I..pp..th...cp.........hDG....hVIoHGTDThp.TAhhLs..h....hl.....ps.........s..........KP..VV.lTGu.pP............s.p.hsuD.G...hNL.hsA....l...hlAus...........................t.......spG....Vhls.hNs.c............lhpupcs...........o.K.sp..os.sh.s.s.F.pSs..s.hs.sLu.hl........st...clth.h.pssht.........................................................tt..t..........................h.....s..p.......p.h...s.p...Vsllt..hY..sGh.ss................phlcsh........l....pt.......s....h...........cGl....lltuh..GsGN..............hstshhp....t....l.p....p....hh...p.p...G.......................lsV.Vhsop..........shsG.tss........th.....s..s..u..h.tlt..c.................h.Ghl.su...t..s..hssppAhhhLhhhLsp..ths.pth.....................................................................................................	0	339	683	964
+1263	PF01112	Asparaginase_2		Asparaginase	Bateman A	anon	Sarah Teichmann	Domain	\N	19.40	19.40	19.90	19.50	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.99	0.70	-5.71	7	2653	2012-10-03 21:14:07	2003-04-07 12:59:11	13	21	1641	72	1019	2127	867	259.80	32	88.17	CHANGED	sshhIs.lpG..utsslsps......hPh.hphht..hh+pssptuhcsLpuGsssLDsVE.ulchlEsp..chssGhGus.spsGpsph-AslMDGsshcsGAVuslp+l+NPIplARhVM-pTsHlhLsh-uAppFApspGhcp.s.ophtopp.hpchhtsppts....pl..D.osh.................l.ptpp...........hsTlGhVAlDspGplAuuTSTuGhs.KhhGRVGDSPl.GAGsYAschsu.soATGpGEslIRthsuhplsthMchGt...phsptshphlhcthPc.......hssGlIAlstpGcluhshss.uha..h.sAspss.h..Ysp.s...p	.......................................................................................t.............................................th.h.......hp...thh.p.........t..u.............p..h..L............p......t......G.........t.................s............A.l................D....s...Vttulphl...E.....sss....hhNuGhG.ushst.............sG.p.h.EhDA......s.l..M.............D..........G........p...........s..........h.......p..s......G............A.V......uu..l..p.pl..+N.Pl.....hA..........+.........h..........l..........h..............c......p...........s...........................H..............s.........h.........h.........sGp.......GA....p.p.a.A.h....t.t.....G..h...t...h....h....s............t.....h...................o...........................thp.ph.t....t....h.ttt................................t....t...............................................................ttp..............................................................hsTV.G.sVA..l.D.t.p.G.pl.A...A....uTSTGGhs.Kh.G.R.VGD............o..P.ll.Gu..G.s.............a........A........s.............s........t............s........s.....s.....o.....s..T...GhGE..hhh+h.....h..h.............u...hp..l...s.t...h...h......c.tt............th.t...ps.s..th.l....p..t..h.t........................stsull..s.l..st.pGp...h...s..hsh.ss......th................................tt.......................................................................	0	291	539	822
+1264	PF04958	AstA		Arginine N-succinyltransferase beta subunit	Bateman A	anon	COG3138	Family	Arginine N-succinyltransferase EC:2.3.1.109 catalyses the transfer of succinyl-CoA to arginine to produce succinylarginine. This is the first step in arginine catabolism by the arginine succinyltransferase pathway.	29.40	29.40	31.90	36.50	25.30	29.30	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.86	0.70	-6.02	71	1133	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	909	1	204	701	163	330.90	51	97.92	CHANGED	MhllRPlptsDlsuLhplAppo...GtGh.TSLPsscchLpp+Is+SppoFtspphspsupps...YlFVLEDocoGcllGssuIcAsVGhsp.PFYsY+lupllHsS......ccLslppphcsLsLssDhTGsoElCoLFLcssaRps..tsGcLLS+uRaLFhApapcRFu-pVlAEhRGlsD..-pG..pSPFW-uLuc+FFsh-FscADhLoGlssKsFIAELMP+aPIYVsLLsp-AQsVIGpVHssTcPAhclLEpEGFphpuYVDIFDuGPTlEAclcsl+oV+pS+thpVp...............tsu....pp..hLluNsphps.........FRAshsphths...s.splhlsscsAcsLplps.GDpVRhlsl	..........MhVlRPlcpuDlsALhpLAs...co...G.sGL.TSLPsNcspLusRIcRuhcoapuch...stuEpG...YlFVLEDoE...TGpVsGlsAIEsAVGLs-.PaYN.YRVuTlVHAS......+EL.sVaNslsTLhLSNDaTGsSELCTLFLcP-aRpp.....sNGhLLSKuRFhFhAuFR-+Fs-+VlAEMRGV.D..EcG..hSPFWpuLG++FFuhDFocADaLs.GsGpKuFIAELMPK.aPIYsphLSpEAQsVIG.pVHPpTtPAh.............s....l..LE+EGFcYcsYlDIFDGGPTLEC-l-clRulRcScllpVs.u.......ps..stsshss...hLVuNp.sacc.........FRssLscscss........sppllLostph-ALcsps.GDpVRlVt.L..........................................................	0	43	78	145
+1265	PF04996	AstB		Succinylarginine dihydrolase	Bateman A	anon	COG3724	Family	This enzyme transforms N(2)-succinylglutamate into succinate and glutamate. This is the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway.	20.10	20.10	20.10	38.90	19.60	20.00	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.46	0.70	-5.68	4	825	2012-10-01 20:45:11	2003-04-07 12:59:11	7	3	787	14	131	513	157	429.90	67	99.25	CHANGED	M.sAaElNFDGLVGPTHsYuGLShGNlASppNuttVSNPRtAAhQGLsKM+sLhDhGhsQuVLPPptRPssslLRpLGFSGSDEtVLppsA+-A.sLLuAsSSASsMWsANAATVsPSADTADGRVHhTsANLssphHRSLEussTtpsL+tlFsDEp+FAVHusLPtsuphGDEGAANHsRLsucaGssGVplFVaGR...-u..stsuRaPARQThEAspAlARLpGl..spslFAQQssssI-tGsFHNDVluVuNtpVLFtHppAFtcpsplLAEL+A+lsG.....hhlpVspsplulpDsVuSYLFNSQLLShs.DGpMhLllP.EsR-NstsWshlppLhuuDsPIscVKVhDLRQSMpNGGGPACLRLRVsLsEtEhsAlNPAhhhsssLhDsLscWV-RaYRDRLosuDLADPpLLpEuRpALDtLoQlLsLG.shYsFQ.....ss	..............MsAaEVNFDGLVG.THHYAGL..SFGNcAST+HchpVSNPRhAAKQGLlKMK.ALADhGFsQuVlPPHERPhlssLRpLGFoG.SDEQVLcKsARQAPchLSulSSASsMWsANAATVuPSADThDGKVHhTVANLNNKFHRSlEAssTculL+AIFsDEc+FuVHsALPpVAlLGDEGAANHNRLG.....GcYGcsGlQLFVYGR.....c-s..s...c...s...c..PsR.YPARQTREASEAVARLpQlsPppVlFAQQNP-VIDQGVFHNDVIAVSNRpVLFCHppAFs..cQppllspLR....s+lsG......FhuIEVPsspVSVuDAVuTYLFNSQLLSRs..DGSMh...LVlPpECR-csuVWsYLN.c.L.l.A.u.D.sPIs-l+VFDLRESMtNGGGPACLRLRVVLoEcERpAV..NPuVhMND.sLFssLNsWVDRaYRDRLTsADLADPpLLcEuRpALD.LTQlLsLG.SVYPFQ.c....................	0	24	49	91
+1266	PF04952	AstE_AspA	Aste_AspA; 	Succinylglutamate desuccinylase / Aspartoacylase family	Bateman A	anon	COG2988 & Pfam-B_15640 (release 10.0)	Family	This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.).	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.67	0.70	-5.53	33	2822	2012-10-02 19:46:12	2003-04-07 12:59:11	9	14	1568	43	782	2774	810	264.10	21	80.56	CHANGED	sG.slllouGsHGsEhsGs.llcclhpplsttp....hsuphhllshsNs.Ahpssp......Rhhs........psLN.....................RsFsGctpu............spsc+lAphhhtthh.sps-hslDLHouspuhshh.hshsshtss.h.....hphlpsh..shshsh.hpptsss............sh.phsspphut.ulolElGts..tshstptlsphttsltslLphl.uhhpsp......p.hthhphstpssptpp..u..sGhhchphplsspV-ttshhshshlhsphsscph.hpu...spsshllhhp.tshsttssslhhltpt	...................................................................................................tlhlsuu.lHGsE.hsu....h....t....hlpp.L.l..........p....pl..t.ttp............hh.u......t...h........l.......ll.slsNs.u.hp.ptp...............................................R.a.h.....................................pDhN..............................................R.h.F..s..G.p.ps...........................................s...hpph...s..p.th.......h..p.t......s.........t............p..s.....ch..h.lD...L...Hou.......h.....p..s.......t...h..h....h.....h.s.h.....h.s.h.p..sh.....h...............hth.ht.sh......sh.s..hl....h...ppt..s.ss.......................................s.h.hp.h.....s.....s.....p..p........h.......u......t............u..........h.o.lEhGts.........h.hstpthpt....h...ttsh.ht...hhthh...u.hhpst..................t.....h.h..t.hh.t....h...t...t.......p............................p..h..t..h.......t..hupp...stthp.h..s..l..h..s.....s..t......h.....hhs..........psthllh.p..shht.tsslhh....t.........................................................................................................................................................................	0	179	407	606
+1267	PF03115	Astro_capsid		Astrovirus capsid protein precursor	Mifsud W	anon	Pfam-B_2957 (release 6.5)	Family	This product is encoded by astrovirus ORF2, one of the three astrovirus ORFs (1a, 1b, 2). The 87kD precursor protein undergoes an intracellular cleavage to form a 79kD protein. Subsequently, extracellular trypsin cleavage yields the three proteins forming the infectious virion [1].	25.00	25.00	28.80	27.90	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	787	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.35	0.70	-6.28	11	1664	2009-09-13 08:26:15	2003-04-07 12:59:11	9	6	167	5	0	782	0	200.70	66	92.28	CHANGED	MASKSsKQVTVEV..NNNGRsRSKSRsRSQSRGRs+uVKITVNS+....s+uR.RQsGRsKhQSNQRVRpIVNKQLRKQGVTGPKPAICQ+ATATLGTIGSNToGsTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVVRlSLNPTSTPSSTSWSGLGARKHLDVTVGKNAlFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLG+TMSSYpNpQFTGGLFLVELuSEWCFTGYAANPNLVNLsK........STDKpVsVTFEGSsGsPLlMsVPEsSHFARhsspRSohsToLuRAGtpooSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRsRoGs....+pFYVYPSYQDALSNKPALCTGuss.uuhRspssVtTTLQFTQMNQPShG+GEoPAThGRulPpP.........G-phpVlhTlussh...uPNssspQsWltKshsuPps........hslKIGpssp+YhshpGFT..........lsuV-WYTs-aQsupcP...........sPIsGlt....VhsssoKKADVYAhpQatsspTNs+pQlTolaLV+V...Tp...............sapVssahshhaptussss......ssslplRssTtssslpFppGpWYLlTsTsl+s.ussssGWlW.shELtsspsYhhDpshsHlIsP.Pssoplha-hhTulPpspsth.shppcss......................ss.pss-s.......hss-ETDs-sEosEDEsD..ElD....RFDL+soSsSEsED...ENsRVTLLsTLlNQGholpRAT+IopRAaPT.....s-+h+RuVahDLLssGlsPuuAWSHACcpARhhuh....pp..phS.GSRGHAE	............................................................................................................................................................................................................................................................................................................................................QRATATLGTl.GSNTSGoTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVlRVSLNP.TS.T.P.S.S.T.SWSGLGARKHLDVTVGKNAsFKLKPSD...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1268	PF04377	ATE_C		Arginine-tRNA-protein transferase, C terminus	Kerrison ND	anon	COG2935	Family	This family represents the C terminal region of the enzyme  arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway  of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis.  N terminal cysteine is sometimes  modified [1].	25.00	25.00	25.30	25.40	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.53	0.71	-4.08	166	1296	2012-10-02 22:59:21	2003-04-07 12:59:11	10	12	1200	0	497	1090	425	134.00	35	43.75	CHANGED	pEpasLYp+YhpsR..HscGsMtsss...h...........ppappF...lpso.l.............................................................................................sohhlEap.............tsscLluVulsD...lLscGl.SuVYoF..aDP-..h.pptS.LGoaslLppIphucc............hsLsYlYLGYaIcsstKMsYKspapPhEl....LssspW	....................................................................................................................................................EpasLYp+Y.ptRH.tcushp..s.....t..............ppa.p.p.F...lps.s.h..l.............................................................................................s.o.hhlcah....................hss..cLlAV.ulhD...lLs.....c......u.....lSuVYoF.............a..D..P..D....h.pp..h.S.LGsaulL.p.pIphu+p................hsLtalYLGYaIcsstKMsYK.spapPtEhLsspt.............	0	143	288	400
+1269	PF04376	ATE_N		Arginine-tRNA-protein transferase, N terminus	Kerrison ND	anon	COG2935	Family	This family represents the N terminal region of the enzyme  arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway  of protein degradation by conjugating a de-stabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis.  N terminal cysteine is sometimes  modified [1]. In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important  for activity [2].  Of these, only Cys 94 appears to be completely conserved in this family.	21.10	21.10	21.10	21.50	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.91	0.72	-4.17	128	1240	2012-10-02 22:59:21	2003-04-07 12:59:11	8	8	1160	0	466	1031	317	77.30	35	25.38	CHANGED	pahhTsshsCuYLss................................+pppphhst...stthssphYspLhptGFRRSGshhY+PpC...psCsAChslRlssspFpso+oQ.+R	........................hhTsspsCuYLts...........................................cp.tcp.hst.........spt.......hs........sphYspLhptGF.R.RSGshhYRPtC....csCp.........uChslRlssscFpso+oQ+R..............	1	131	266	373
+1270	PF03078	ATHILA		ATHILA ORF-1 family	Mifsud W	anon	Pfam-B_2240 (release 6.4)	Family	ATHILA is a group of Arabidopsis thaliana retrotransposons [1]  belonging to the Ty3/gypsy family of the long terminal repeat (LTR) class of eukaryotic retrotransposons[2,3]. The central region of ATHILA retrotransposons contains two or three open reading frames (ORFs). This family represents the ORF1 product. The function of ORF1 is unknown.	19.50	19.50	20.20	20.50	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.52	0.70	-5.90	11	113	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	9	0	38	110	0	201.90	16	53.65	CHANGED	p++tElARGKRshps...........c.pl.pE-h-...-..stsst+tpph.p+tcc.TspEYh+hhp..cFhuTRYPp.pThtpLGlhcDVpalhppspLpshhuh.asuaccEolpFLSTLclcha....s.th-.cG.lGalpFhVhshpYplsIppLpphaGFPotpuhp..casp-ELpsLWhpIuushPhs.u+SKSs.IRsPVIRYhppslANshasRcpTGTVoNs-hEMID.ALptlL....RcTKsGpslcGDh.NDsshohlLL.HLhuY+paAhs.ppp.htGuLChGGllT.ILhussVslts.sh.P+hhDhcaLptpc.hphthssDhhha+Fpcs..t.u.hhLPs.chTpIhptpNI-FpPphphL...............s...ppp..hhptttpppl...-tpscpcph-...h-Ts.aHFpEah.Psp.pu+sluEsH+p.uhLp+WsphQcKlltphhKtl+hhpptlpshussp	..........................................................................................................................................................................................................................................................................................................................................h...................................................................................................................................................................................................................................................................................................................h.............................................................................	0	3	3	6
+1271	PF03477	ATP-cone		ATP cone domain	Aravind L	anon	Aravind L	Domain	\N	21.50	21.50	21.50	21.50	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.95	0.72	-3.55	133	9433	2009-01-15 18:05:59	2003-04-07 12:59:11	11	53	4693	82	2010	5803	3748	89.30	26	18.76	CHANGED	hhVlKRDG.pttsFchpKItpulpcAs.................t.h.....stp.p.spplspplhpp..lps...t....tl.ssccIp-hVpppLh.................cts.....thshs+thlh..YRph+ct	..........................hVlKRDG.p.p.psFst-KItpulh+As...........................................tt...ps.l..........sps.p...lp....p.l..sp.clp.pp....lps......t...............pl.sspcItphVhcpLh......................chs.....ph.s..hl+ht.sYRph+c.h...............................................	1	650	1237	1685
+1272	PF02222	ATP-grasp		ATP-grasp domain	Bateman A	anon	Pfam-B_157 (release 5.2)	Family	This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.12	0.71	-4.91	23	5314	2012-10-10 13:17:02	2003-04-07 12:59:11	17	15	3695	55	1212	22317	9135	171.00	35	44.36	CHANGED	l.pphGlssscahhlcsts...plppssppl....GhPsVlKtpphuYDG+Gphll+sps-lppuhcth......tstslllEcalsFctElollslR..shcGt..shhaPslcslpccGlh+hshsPAthstt...htppApplAc.clscpLsssGlauVEhFlh...sGc......lllNElAPRPHNSGHaTlsus	..........................................................................................................................h.cchuls.s..u...s...a...t..h.....l......s...o....t.p.........-.l..p....p.....s.....h....t......p....l...............G..h....P..s.llK.t.s.h.h.G.Y.D.G..+....G......Q....h...h...l.......+........s...t..p..-....l.p..t..u..h.phh.............................ssspsl.l.E.p.h..l.............s...............F...c.........h..................E............l..o..l.......l........s......s...R.................sss...G......p..............s......t........h.......a.......P.................s..............s......c............s........h.............p...........c...........s............G.............l.............h................p..........p..................S...........h.............s.................P......s....p.....h......s....s.t...................ht.p...p.A.p.p...h.Ap....pl.....s......p.....t.....L................s.........h.....s...G......l....h....u....V..E.h.Fls........p.G.s....................lllNElAPRPHNSGHaTlpu......................................................................................................	0	320	712	992
+1273	PF00217	ATP-gua_Ptrans		ATP:guanido phosphotransferase, C-terminal catalytic domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.	21.90	21.90	23.10	23.00	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.44	0.70	-5.05	115	3578	2012-10-02 17:21:26	2003-04-07 12:59:11	14	21	2750	104	545	2666	91	185.20	48	68.74	CHANGED	s.-s.chVlSoRlRsuRslcGhshPPph.ocp-pcplEphlpsALssl.....suchp.GpYasLss.....MostppppLl-cH......aLFpc..ss.hh.suthscsWPtuRGIahNcs+sFllWlNEEDHlRlISMppG...uslppVacRhspulptlE........cp.lcFuas-+LGYLToCPoNLGTGLRASVHl+LPtLuts....sc.hpphhpplpLphRGhtGEsoc.uhG...slaDISNppRLGhoEh-lVppl.hsGVpplIchE+ph	..............................................................................................sscallSoRVRsGRSlcGasFsPsh.T-t.p.h+E.hEpcV.sssLsuL.............cG-LK...Gsa..Y..P..Lou...........Moccs.Q..QpL.IDDH..............FLF...cE.......ss.hLp...s...A...sh.sRhWPsuRGIa..HN......-..s+....ohh.VhhNEEDHlRl.uMp.G....................hshtp...sapphsph...ptl-.........cth.a..a.pc....plGalh.....hCPoNlGTshRAuVhl...+l...PtLshp......tch.p.hh..t.ph...t......h..thR...Ghh......G....ts..........t.................................................................................................................	0	243	305	418
+1274	PF02807	ATP-gua_PtransN		ATP:guanido phosphotransferase, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain has an all-alpha fold.	25.70	25.70	25.70	26.10	25.60	25.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.48	0.72	-3.83	91	1908	2009-01-15 18:05:59	2003-04-07 12:59:11	10	20	1186	104	380	1509	23	67.60	62	24.46	CHANGED	schsp...ppslhpKaLT.-lapcL+sKcT..shGsTLscsIpoGl-Nss.....psVGlhAuDtEuYp..lFu-LFDslIc-hHsGa	.................................ppshhtphL..T...-l..acpL+s.+.pT..shGsTLhDVIQoGl-N.s........................psVGlYAs.DAEuYo..VFA-LFDPII-DYHuGF..................	0	158	187	276
+1275	PF01747	ATP-sulfurylase		ATP-sulfurylase	Bashton M, Bateman A	anon	Pfam-B_494 (release 4.2)	Domain	This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulphate [2]. ATP sulfurylase catalyses the synthesis of adenosine-phosphosulfate APS from ATP and inorganic sulphate [1].	23.40	23.40	24.40	23.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.33	0.70	-5.03	113	1308	2012-10-02 18:00:56	2003-04-07 12:59:11	12	15	1032	36	520	1170	549	214.80	37	43.51	CHANGED	asphpho....PtEhRphF.pc.pGWc..pVlAFQT.RNPhHRu.HEhLt+tAhct.h..s........ulLlpP.LlGtpKssDlssclRhcsacsllcp.Yh................PpspshluhhPhsM..RYAGPREAlhHAlhRpNaGsTHaIVGRDHAGlG..........s..aYGsa-AQclhcp..............ts-L..sIp.l.hcpshY.spcssphssh..........cssscspcp+.lplSGT...........clR.chLppGttsPshFsRPEVsclLhch.h	.........................sphphsPtEhRppF....cc....hshc....sVsAFQo.RNPlHRu.HchLhppAhct..h...s.........sLllpP.LlG.TKssDlPtcsRhcsacs.ll..cp.Yh................stspshlulhPssM..+....YAGP+EulaHAllR+Nh.GsTHaI.VGRDHAGsG...........DaYssacApclhsp.............hss-l..sIphl.FcpshY.sppspthhs...........cpsscs...pcpc..lhlSGT...........clR.chLRsGttPPshF.pPEVsclLhc..................................	0	179	315	435
+1276	PF00231	ATP-synt		ATP synthase	Finn RD	anon	Prosite	Domain	\N	22.10	22.10	22.40	22.40	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.76	0.70	-5.06	161	5197	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	4653	59	1266	3418	3462	281.00	34	97.64	CHANGED	AsL+-l+pRIpSlpsTpKIT+AMchV.AuuKl++Apcphpss+PYsp.plppllspl...htt.................................t.t..pshhttc.....pspcs.......hllllooD+GLCGuaNssll+tstphlpphpspt....ph...plhslGcKutsahp..p.h.............shp.lht.........phssls.cssshppsp.tlsppllpta...hpt..p.................................hDc..lhllYscF.hsslsQpspspplLP...............................................ttpttttttpsph.aEP..sscplLssLlspYlpsplapullEuhASEpuARMsAMcsATcNAs-hlpcLslpYN+sRQAuITpElhEIl.uGApAL	................................................................sh+-I+s+ItSlpsTpKIT+AMcMV.uuuKl++upcphpsu+PYup.phppllspl..sps..t.............................ph.p..pP.hl.ppR............psK+s.....uhlVloo..DRGLCGGaNsNlhKp...sh.ph..hp..p.hp...s.ps...............hp.h.pl.hslGpKGh..saap....p..t.............................uhp...lht..........phsslu....-pP..sh.p.cst..sl..s..pp.hlpta.....pps...p....................................hD....c...lallYs+F..l..s..s.h..oQpsphpplLPl....................................................t..t.s..p..t.tp..p.tph.sY...aE.P....s..s..cp...lLcsLLspYlpu.lYtull-uhASEpuARMsAMc........sATDNA......s...clIpcLsl.YN+uRQAuITpEloEIVuGAsAl.........................................................................	1	435	822	1071
+1277	PF05176	ATP-synt_10		ATP10 protein	Wood V	anon	Wood V	Family	ATP 10 is essential for the assembly of a functional mitochondrial ATPase complex [1].	21.90	21.90	23.80	24.70	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.42	0.70	-5.11	23	186	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	169	0	137	174	20	237.20	27	80.37	CHANGED	puh...........p..p....sspstptch...htLs+PlGh..PPp.s..pphs-spoLpp..htpDhhsh-K+tcRpKELst-hu+uhFt-hpsh+pppGKhFhuPsphFKpDKALYFPsht.....G+TL..............sus.....pssp.......shLcGKlSlVplFSoshuEppspoahp.....sshp-hhpps.t.........psQll-INl.-shl......KuhLl+lh.hsph+ppl.PtppapcY..Flsp.cs.hs.sl+Eplth.NshsGYlYLlDcps+IRWAuoGsAspcEhcsLh+sV+tL	..................................................hht...................t......l.+PlGh..sP..............s...pph..ptpohpt...........-hhs.-+....p..p+pccL..........t.....t...c.hs+.s...hat-hpsh.ph.p.pGKhFhuss.pha+t-puLaFPslh..............GpoL.............................ssp.......tshs...........shl..p...G.K.sSlVslao..o.hh.u-p.spoahp..........shhpphhpps......................tsQ.hlclNh.-shl......KuhLl+hh.hssh+..ppl..Ptppasp...Y..alsp.....ps.h...s.plR-plthhNshsGYlaLlDpps+IRWAusG.Aps..pEhcsLhpssptL....................	0	41	82	117
+1278	PF00895	ATP-synt_8		ATP synthase protein 8	Bateman A	anon	Pfam-B_446 (release 3.0)	Family	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.02	0.72	-3.76	66	6876	2012-10-02 21:03:42	2003-04-07 12:59:11	15	1	4964	0	41	6086	109	52.90	39	95.77	CHANGED	MPQLssss......Wahhllhhhlslhllh.hKlhsah...ssss......sppspppppssPWpa.W	....MPQLNPsP.......WFhIhlho..W...Ls.ah.hl.l..sKlhsas.....sNsP...........ssp...s.....s.pp....p.s.ps..W..sWPW.................................	0	8	12	21
+1279	PF00119	ATP-synt_A		ATP synthase A chain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.70	21.70	21.70	21.70	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.44	0.70	-4.84	30	17567	2009-01-15 18:05:59	2003-04-07 12:59:11	15	12	11908	3	1063	15216	2921	204.40	33	91.02	CHANGED	hslshpslhhhlhshllhhhhhhh..p......hPsphpshhphlhchlpshlpsphstps...httahslhholFlalhhsNhhG.LlPasFs................sTuclslThuLAlslaluhhlhGlppcshsha..phhls.hs...hlPhhl.hlEllS.hs+PloLulRLhuNlhAGcllltLlushh...............hhullshhlh.........lhhhhh-lhluhIQAalFshLshlYls-	.......................................................h........h...h.h.l.h.h.h.l..l...h.h........h....h....h....h...................................t......h..........lss...R....h.p.s..l.p.hhl.phh.s.p.p....l.h.t.s.l.s.tpu...........c.p.au.hh.......l..hoLhlFll...hhNhLG...L.l..P.Y....s...F.T................................................................................PT.opLu.hshuL.Als.l.W.lus.ll.hG.h+.p...p.s.....tts.h.......u+h..l....P.....p.......G......o........P..............h....................L....l.....P.......h....L....l...l......IE.sl.S.h.h.h.RPluLulRLhANlhAGHL.L.lp.Llushshs........................................h..h.h.u.l.l..s.h.hlh...............hhl.shLEl.hVuhIQAY.V.FslLhslYlp...................................	0	343	689	893
+1280	PF00006	ATP-synt_ab		ATP synthase alpha/beta family, nucleotide-binding domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	This family includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null --hand HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.34	0.70	-4.84	157	33595	2012-10-05 12:31:08	2003-04-07 12:59:11	20	61	14564	479	5203	24829	10876	206.20	38	47.96	CHANGED	TGl+sIDshhPlu+GQRhsIhussGsGKosLhtplspss....................p...ssss....lhsh..........................................................................................................................................................................................................................................................................................................................................................................................................................lGERscElp-hhcph..............hsp........tsh.......................p+.olllsususcss...ht+htushsu.hslAEaapp.pGp.cVLl.....lhDslTRaApAhREluhthuc..sPupcGYPssla...shlsclhERAGph...................................ttGSlTul.s...lhstusDh.s-PlsssshulhDGplhL..s+cLsppuha.PAIDl....htShS	.....................................................................................TGlKslD.h.l.s..P..h.u+G.t.+.hs.lh.G..ss.GsGKTs.lhh.-.lIpNh.................................s...psts..........sVas.u..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lGE.Rsc..Es.s....-lh.pch..................................ccs.......ss.h............................pcsslVhu....p..hs-P.s.......stRh.psu.hou............loh.A..EYFR............D......p............u..........p............D............V.Ll.....h.....hDsl....hRaspAhpElS....hl...Ls.....R...Pu.thGY.sslh.....tp.h.upL.ERhsps..........................................................ptGSlTul.s...lh.s.....us.Dh..ocsh.P..ssshuhh......D..u..phhL..s+pLt..tpGlaPAl.sshtSsS..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	1807	3311	4366
+1281	PF00430	ATP-synt_B		ATP synthase B/B' CF(0)	Finn RD	anon	Pfam-B_137 (release 1.0)	Family	Part of the CF(0) (base unit) of the  ATP synthase. The base unit is thought to translocate protons through membrane  (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits.  This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in Pfam:PF00006	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.33	0.71	-4.35	27	5963	2012-10-02 21:03:42	2003-04-07 12:59:11	13	9	4775	3	1260	3817	3365	130.10	24	75.06	CHANGED	sl.htllshhlllhlLhhhhhpsLtplLcpRcptItsslppAEcphpputphhtctcppLppA+tcApcllppApppupphtpphlspuppchcplhpsAtsclpppcppuhppL+pplssLulphspphlp	................................hhhphlsFl...l.ll.h.l.l.h..+..a..s....a....s.....s.........l.h.sh...l-cRppcIt.sslssA-cs.+.pc.u.p...th.t.pctpppLppA+tE.Ap....pIl......pp....Appcup....ph....hcp...hh....s....p....A...pp....-.tpc....l....h....ppA....ptc....Ip.tp....+pcAhppl+pp....V.upLulthAp+ll...............................	0	418	853	1083
+1282	PF00137	ATP-synt_C		ATP synthase subunit C	Sonnhammer ELL	anon	Prosite	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.05	0.72	-4.07	167	10204	2009-09-13 08:00:21	2003-04-07 12:59:11	16	24	5907	292	3091	5928	2123	66.90	28	77.67	CHANGED	hshl.GAGluhuluslGuulGhGhsuuushpuhu+pPc....lhsphllshuhsEshulauLllulll..lhs	.................thluA.uluhu.luulG.uulGhGhsuu.s..hlpu.....sARpP-.........................lhsphllshuhsEulul.a......ulllulllh......................	2	1106	1902	2580
+1283	PF01813	ATP-synt_D		ATP synthase subunit D 	Bashton M, Bateman A	anon	Pfam-B_1304 (release 4.2)	Family	This is a family of subunit D form various ATP synthases including V-type H+ transporting and Na+ dependent. Subunit D is suggested to be an integral part of the catalytic sector of the V-ATPase [2].	22.30	22.30	22.30	22.40	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.17	0.71	-4.75	114	1524	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	1253	6	536	1171	151	187.10	30	85.70	CHANGED	hpLhphKp+LphAp+GapLLKcKc-sLhhchhpllcchpch+pplpcth.pcAhtslshAph....utthhptlt.sstp..phplchppcNl.hGVplPhhchtp....................................ht.tsauhhssuspl-cuhcpapcslchllclAplEpshttLsp-lcpTpRRVNALEpllIPchcssl+aIphpL-EpEREphhRLKh.lKpp	....................pLtthKp+LpsAp+G+pLLKcKp-tLh.....hc......Fhpll.cchpch+pphpphh.ppuhtsh.shAph.....hutthhpplht.spp...phplchppcNl..hGVplPhhchhp.............................................................tts.h.au.h.hpsspplcc.shpphpchlphllcLAplc.....pshhhLscpIcpTpRRVNAL..............Ep..lh.IPphcpTlpaIphcL-EtERpphhRLK+lKp........................	0	199	334	452
+1284	PF00401	ATP-synt_DE		ATP synthase, Delta/Epsilon chain, long alpha-helix domain	Finn RD, Griffiths-Jones SR, Kerrison ND	anon	Pfam-B_114 (release 1.0)	Domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. This subunit is called epsilon in bacteria and delta in  mitochondria.  In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	24.60	24.60	24.70	24.70	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.35	0.72	-4.08	179	3444	2009-12-15 10:59:44	2003-04-07 12:59:11	15	6	3304	16	491	1953	627	48.40	37	35.06	CHANGED	c-IDhpcAppAhccA-ppLtpt..ps.ct....-hhcAphsLp+AhARLcshpth	........pDID.p+ApcAKc+AEpplppu....cu.ch...........-htcAphA.LpRAhsRlcshph.t................	0	154	303	405
+1285	PF02823	ATP-synt_DE_N		ATP synthase, Delta/Epsilon chain, beta-sandwich domain	Finn RD, Griffiths-Jones SR, Kerrison ND	anon	Pfam-B_114 (release 1.0)	Domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria.  In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	20.10	20.10	20.60	20.30	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.29	0.72	-4.22	327	5637	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	5213	39	1228	3611	2337	79.90	32	59.02	CHANGED	lplclVoP-chlassp.lc.lhssuspG-hGlLssHsPllosLc.s.Ghlclp..ts...u......pp........phh.hlsGGhh-.Vp..s.splolLu-sA	............................hplplVoP.-.p.h.lasuc..Vc.lhls.....s..s.p.G.-lGlLPsHsPlloslc.s....G.h.l+lp....ts.....s...................pp.......................chl.hls.G.Ghl-lp..s.sp.l.o.lLA-sA......................................................	0	402	786	1040
+1286	PF04627	ATP-synt_Eps	ATP-synt_E;	Mitochondrial ATP synthase epsilon chain	Kerrison ND	anon	DOMO:DM04624;	Family	This family constitutes the mitochondrial ATP synthase epsilon subunit.  This is not to be confused with the bacterial epsilon subunit, which is homologous to the mitochondrial delta subunit (Pfam:PF00401 and Pfam:PF02823) The epsilon subunit is located in the extrinsic membrane section F1, which is the catalytic site of ATP synthesis.  The epsilon subunit was not well ordered in the crystal structure of bovine F1 [1], but it is known to be located in the stalk region of F1 [2]. E subunit is thought to be involved in the regulation of ATP synthase, since a null mutation increased oligomycin sensitivity and decreased inhibition by inhibitor protein IF1 [2].	20.50	20.50	21.80	20.90	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.35	0.72	-4.41	30	309	2009-09-10 16:25:20	2003-04-07 12:59:11	8	6	257	30	199	292	1	49.00	38	53.74	CHANGED	huuWRtAGloY.pYssIAA+sVRcuLKp-h+ssAt+Rsp.scl...............KascW.psG	................shWR.tAGloYh+YsslsAcsVRpuLKpph+spAt+Rst.spl...............+hscWpsG..............................	0	63	113	163
+1287	PF01990	ATP-synt_F		ATP synthase (F/14-kDa) subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes 14-kDa subunit from vATPases [1], which is in the peripheral catalytic part of the complex [2]. The family also includes archaebacterial ATP synthase subunit F [3].	23.50	23.50	23.50	23.50	23.40	23.20	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.29	0.72	-3.60	100	1179	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	1012	17	454	861	109	94.90	28	86.32	CHANGED	luVIGDc.Do.lsGFtLuGlsph.sh...........................ssc-lccslcchh.pcp-luIlllspclu......cc.lcctlcph..pp.....shPsll..pIPspptshshttss..lpt.lc+	..................................................luVIGDc......Do.lhGFpLhGlsthsst...........................stp-hccslcchs..............c............p-h.....u.........lIhlopplA..............pt.lpcplcpa..p.p.....shPs.ll...IPo+pt..sh.shuhsp..l.p.lc....................................	0	171	280	387
+1288	PF04911	ATP-synt_J		ATP synthase j chain	Wood V, Bateman A	anon	Wood V	Family	\N	20.70	20.70	23.30	22.70	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.74	0.72	-4.51	18	106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	102	0	80	91	0	52.30	45	78.02	CHANGED	+FPTPVlKPhhPFFsuGsllhYGlsphAss.hsocEFhNDPRNPpht..s.pttH	...KaPsP...lhKPhhPFFsAGhllhYGlsphtsAhhsocEapNDPRNPpht.tt.t...t................	0	23	47	70
+1289	PF02038	ATP1G1_PLM_MAT8		ATP1G1/PLM/MAT8 family	Mian N, Bateman A	anon	IPR000272	Family	\N	19.80	19.80	20.80	20.10	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.47	0.72	-4.95	23	266	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	47	12	108	287	0	49.20	42	44.01	CHANGED	scsp..-PFaYDYcoLRlGGLlhAulLFllGIlIlLS..t+C+C.phsQcp+phs	..........-c..-PFhY....DYpoLRlGGLlhAulLFllGI.lllLS......t.+.C....+C.phspp.pt..s.................	1	9	11	27
+1290	PF03899	ATP_synt_I		ATP synthase I chain	Finn RD	anon	DOMO:DM04622;	Family	\N	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.35	0.72	-3.84	154	2035	2012-10-01 19:47:47	2003-04-07 12:59:11	10	1	1796	0	377	1164	184	94.90	20	74.16	CHANGED	+lhhhphhlhh.lhsls...hhlh...........shp...huhu.....hlhGuhlullshhhhshps...httthst...pphht..........hhhG.thh+hhlshhhhhlshth...ttlph.lslhlGhh	..........................hhhphhlhh..lhslh...hhlh..............tht...hslu.....hllGshsuhlsshlhthhs....hhtt...thst....tpshh..........hhhG.phh+..h.h.hsllhhl.lshth...hphsh.lslhlGh....................	0	107	223	309
+1291	PF03154	Atrophin-1		Atrophin-1 family	Mifsud W	anon	Pfam-B_3427 (release 6.5)	Family	Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins [1,2]. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity [2].	26.00	26.00	26.20	26.60	25.30	25.80	hmmbuild  -o /dev/null HMM SEED	982	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.13	0.70	-13.94	0.70	-6.41	4	230	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	80	0	118	188	2	495.60	34	60.53	CHANGED	GKHSMRTRRsRGSMSTLRSGRKKQTsSPDGRsSPsNEDlRSSGRsSPSAAST....SSsDSKsEShKKssK...KIKEEAsSPhKosKR.REKsASDsEEs-RsouKKoKTQ....ElS+PsSPS..EGEuEGEGE.SSDSRSlN-EGSSDPKDIDQDNRSSSPSIPSPQD.NESDSDSSA.......QQQh.QsQtsPul.sPPusususus..........Ps.sPSusslPPQsSPsuupPss.s....tssshoLl.pAPoLHPpRLPSPHPPlpP.su..utssspPssPs..tPpusHHGPhPPhPHsLQs....uPl.L.aP..sPPQP.uL....upt.sP...sPupA..+o..t..suQssht.PpQPP...REQPLPPAP.uMPHIKPPPTTPIPQ.ss.QSHKHPsHlpuPoPF.pMsSNLPPPPALKPLSSLPTHHPPSAHPPPLQLMPQuQ.LpossAQPPVLTQSQSLPspuSspPpo............uh.phPsQssFspHPFhsushPuIsPPsssssShsussPsuSu..pPssS...shsuSsss......usssssLPsIQIKEEsLDEsEEPESPPPPPRSPSPEPTVVssPSHASQSARFYKHLDRGYNSCARTDhYFhPLuuSKLAKKREEAhEKAKREAEQKsREEREREKE+EK..EREREREREAERAA.............................KASSSuHEuRhu-sQLuussHhRsSFEsPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFaVsLNPsDPLLAYHMPGLYNsDPolRERELREREhREREIRERELRERMKPGFEVKPPELDsLHPSsNPMEHFARHGAlTlPshAG.PHPFAuFHPGLNPLERERLALAGPQLRPEMSYPERLAAERlHAERMASlusDPlARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQ........................GSuuP.HPL.VDPLsAGPHLARFPYPsGsIPNPLLGQ.PHEHEMLRHPVFGssYPR-L.suI.P.MSAAHQLQAMHAQSsELQRhAMEQQWLHGH.HhHGG.LPSQEDYYphhhppus+pL	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hS....P.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	12	22	62
+1292	PF03769	Attacin_C		Attacin, C-terminal region	Finn RD	anon	Pfam-B_2791 (release 7.0)	Family	This family includes attacin, sarcotoxin and diptericin.  All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically to kill the invading microorganism [1].	28.80	28.80	29.70	28.90	26.90	28.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.28	0.71	-3.94	24	176	2009-09-10 15:59:06	2003-04-07 12:59:11	10	3	48	0	58	196	0	106.40	31	59.05	CHANGED	hssa..GsplsssupsNlFpsssHcLsAsAFto+shss...ps.pFsphGGGlsY.atsthGAohusu+pshhs.sshulsG+hNlapSss..oSLDhsuGas+ahussacsSphp.shGhsho+pF	......................................thts.hptthpsslhps.t.cslssps.a..topsh.t.......app.GuGlsh.hh.sthuAuhusuphsshs.pplslsG+sNLWpSssttopLDhsGuhu+ahuGPassptssausGhshoapF..........	0	12	17	40
+1293	PF03472	Autoind_bind		Autoinducer binding domain	Bateman A, Holden M	anon	Bateman A	Domain	This domain is found a a large family of transcriptional regulators.  This domain specifically binds to autoinducer molecules.	21.00	21.00	21.00	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.69	0.71	-4.91	188	2219	2012-10-02 14:34:25	2003-04-07 12:59:11	10	9	1181	48	438	1549	74	144.40	20	58.87	CHANGED	shpp.lhphlpphhpthGacp.hsas.......s.ttstsshhlhs.saPs.sWhp...pYhppsahthDPllptsh...psht.P.hhWsch.ht...........stttp..phhppAppaGl.psGholPl+sssuph.uh..l.ol..stsppshs.hp.....pttplphluhhhapph	.................................................t..pplhp.lpthspphuachhshs...............hhhshshstschh..hhs..sa.P.t..sWhp.......tYppp.sahtlDPllphst....psps..s..hhWscthhptt......................tlhp.t.A.p.p.a.....G..l..ppGl...ohsl...h...s...ss..ss....h..uh..L.Sh....upsstp.ssht......hphphphls..h....h.................................................................	0	65	185	288
+1294	PF00765	Autoind_synth		Autoinducer synthetase	Bateman A	anon	Pfam-B_881 (release 2.1)	Family	\N	20.10	20.10	20.20	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-5.04	13	807	2012-10-02 22:59:21	2003-04-07 12:59:11	12	2	478	5	184	757	67	174.20	26	85.33	CHANGED	sashhscs+..-ElFsLRKcTFKDRLcWsVpCpsGMEFDpYDNpsTTYllGlp-.spVlCSlRFI-s+hPNMIT.GTFtsaFsclslPc.GsalESSRFFVD+u.Rs+sllG.sptPlothLFLuMINYA+spGYcGIhTIVS+sMhpILKRSG.WpIsllppGhupcpEplYLlaLPsDc-spctLh	.......................................pphhph...Rpcl....F..h-....+Ls.W...c....l..s...s.....t.....s...u...h..E.hDpaD.s.s.s.sh..Yl.l...u.h.s..c.....up.lhGs.sRLL.......P..T.......s.....t......P.....h.....h.....L.......p....ss........F........s...p.......L...h.......t.......s........h........s.......h.....P....p.......s..s.s...lWEhSR.F.s...l..stt...h........s.......tt.............h..................s...s....t.........t...................................hs...h..h....lhhu.hlpauhppGhppllsVs.s.hs.h.t+lh+RhG.hthphlG..s...........t..t..p..hhhhhh.hs........h............................................................................................................................	1	22	84	121
+1295	PF03987	Autophagy_act_C	Autophagy_C; 	Autophagocytosis associated protein, active-site domain 	Finn RD, Wood V, Coggill PC	anon	Pfam-B_10019 (release 7.3)	Domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex [2].	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.04	0.72	-3.79	57	558	2009-09-11 22:59:56	2003-04-07 12:59:11	10	8	307	1	391	549	6	65.50	35	23.68	CHANGED	hIsYsphYpsPplaltGas.........p.st.psLs.ppha...-Dlsscatp+T....................lTh-paPh...............hsh...hhslHPC+	.............................aIsYsp..hYpsP+LalhGas........................p..st...pPLsscp...h...h......ED......l..s...t-atp+T............................................lT.h-pHPh.....................hshs....hholHPC+.................................	0	124	202	314
+1296	PF03986	Autophagy_N		Autophagocytosis associated protein (Atg3), N-terminal domain 	Finn RD	anon	Pfam-B_10019 (release 7.3)	Domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the lysosome/vacuole.  Atg3 is a ubiquitin like modifier that is topologically similar to the canonical E2 enzyme [3].  It catalyses the conjugation of Atg8 and phosphatidylethanolamine [4].	20.30	20.30	22.40	25.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.05	0.71	-4.43	29	337	2009-09-11 23:00:31	2003-04-07 12:59:11	8	5	293	3	233	333	4	156.20	35	49.50	CHANGED	tl+ush.sltEaLTPVh+pSpF+pTG.ITPEEFVtAGDaLVa+hPTWpWu.susps+h+saLPtDKQFLlTRsVPCa+Rspphtts......ttt-cllc-p-t...........D..-GWVcTpthssttt.............psschcsls-hsstspp....................ptp-p----hs	...................h.l+uphhsht-hlTPlh.+pSpF+cTGhlTPEE.FVtAGDaLVa+hPTWpWs..s.....us..s......+t+sYLP.tsKQFLlTRs.......VPCh+Rspphths...........tpt-t.llc..-.s.ps...........................-.sG....WlpTtt.ss.ttt...................t.tt..c.sl....s-hs..spp.................................t.....t......ttt..............................................................................................	0	78	126	188
+1297	PF02309	AUX_IAA		AUX/IAA family	Bateman A, Mian N	anon	Pfam-B_801 (release 5.2)	Family	Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin. Some members of this family are longer and contain an N terminal DNA binding domain, such as Swiss:O64965. The function of this region is uncertain.	22.70	22.70	22.80	23.00	22.30	22.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.72	0.70	-4.59	56	1709	2009-01-15 18:05:59	2003-04-07 12:59:11	11	17	106	4	612	1704	1	179.60	27	48.17	CHANGED	LsLctT.E.........LR..LGLPGstt.t................................ptsstsssKRu..Fu-..................................................sstttpssssspppp........psspsP.............................sK.......AQVVGWPPVRSaRK.Nsht....................................ptpst..............haVKVSMDGAPYLRKlDL+hYpuYpELssAL-cMF.usF.olG..............E.phh-hhsGS.EYVPTYEDKDGDWMLVGDVPW-MFlcSCKRLRIMKuSE....AhGLusps	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.h.s..sh.....ssl.p..s.hp..p..s.ht.........................................................t.....t...............thaV.K.VpM-GsshhRKlDLph...a......suYp-LtpsLp.cMF...........sh..t................................................t....hc.......hp.ts...cahlsYc.D.c.....-GDhMLVGD.sPWp...........F........hpss...++l.+Ihptp-.h....................................................	0	67	360	485
+1298	PF02041	Auxin_BP		Auxin binding protein	Mian N, Bateman A	anon	IPR000526	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.07	0.71	-4.81	4	80	2012-10-10 13:59:34	2003-04-07 12:59:11	11	1	41	8	18	138	46	144.30	65	86.11	CHANGED	AupCslpGLPlVRNIS-LPQ-NYGRsGLSHhTVAGSlLHGMKEVEVWLQTFAPGScTPIHRHSCEEVFVVLKGpGTLYLu.SSHuKaPGpPQEFsIFsNSTFHIPVNDsHQVhNTsEHEDLQVLVlISRPPlKlFhY-DW.MPHTAA+LKFPYYWDE-Chpssp...DEL	........................................t.ss.ps.slVRsISch.QssYGt.GLSHhT..lAGu.lh..HGhKEV.EVWLQTFuPG.s.pTPIHRH.S.C.E..EVFVVLKG....sGTLYL....u....sSH.t....Ka.P.GcP.pE....a.sIFsNSTFaIPVNDsHQVWNTsE+EDLQVLVlISRPPlKlF.hY-DW.MPHTAA+LKFPaaWDEpCh.ts.....E...................................................	0	5	12	16
+1299	PF02519	Auxin_inducible		Auxin responsive protein	Bashton M, Bateman A	anon	Pfam-B_1263 (release 5.4)	Family	This family consists of the protein products of the ARG7 auxin responsive genes family none of which have any identified functional role. 	20.90	20.90	21.10	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.50	0.72	-3.95	112	1334	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	37	\N	887	1284	1	94.40	31	75.65	CHANGED	hstphpth.tttp.......thh.tts.tth...........................hP.+GahsVYV........Gc............tpp.RFlVPlsaLs+PhFppLLcpAcEE.F.Gasp...tGs..LsIPCcts.hFcp.lhshlp	.........................................................................tt.......................................p..........................sslP...KGah.sVYV...........G-.............ptc..RFllPl.sYLspPhFppLLppA......EE..E...F.G.asp....tGs.....L.slP.C.cts.hFpplhphl.p......................	0	98	600	754
+1300	PF03708	Avian_gp85		Avian retrovirus envelope protein, gp85 	Finn RD	anon	Pfam-B_3651 (release 7.0)	Family	Family of a vain specific viral glycoproteins that forms a  receptor-binding gp85 polypeptide that is linked through disulfide  to a membrane-spanning gp37 spike.  Gp85 confers a high degree of subgroup  specificity for interaction with distinct cell receptors [1].	21.10	21.10	24.50	23.70	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.85	0.70	-5.14	5	283	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	22	0	0	304	0	223.70	64	47.01	CHANGED	LNVSLWDEPpELQLLGSQSLPNlTNITplou..V......sGGClGFsP..pusGlY.GWsRctlo+aLLccPh.pPaFspsSNSo-PFTVVTADRHNLFMGSEYCGAYGYRFWcMYNCSQoRps........Ys.C..Gcssu..sG.PEsWCsu+GGcWVNQSpEhNESEPFSFTlNCTGSsLGNsSGCCGcssTILP.GAW.lDSTQGSFTK..........PKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDI...LKlLuNSSRTGIRR.KRS	....................LNTTLPWDPQELDILGSQMIKNGTsRTCVTFGSVCYp...tNtSpVCHsFDGNhNGTGGAEAELRDFIsKWKucD.LIRPYVNQSWTMVSPINs.....ESFSISSRYCG.........FTSNETR.Y.........Y+....GshSs........WCsSKGGcW.........SAGYSNGTpCSu....NToGCGGNCT.......uEWNYYAYGFTFGKpsElL......WNNGTAKALPPGIFLICGDRAWQGIPpNALGGPCYLGQLTMLSPNFTTW.....hTYGPNI..TGHRR.+R....	0	0	0	0
+1301	PF01382	Avidin		Avidin family	Bateman A	anon	SCOP	Domain	\N	20.10	20.10	21.90	21.20	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.64	0.71	-3.80	15	142	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	81	454	71	247	4	107.70	29	48.71	CHANGED	s..slpGsWhNchGSshtIss..susGtloGTYhossusssstspsp..slsGah.......s..t..ssoshuFoVsW....spssSsTsWoGQshls..supstlpThWhLsssssssp..WpuspsGtDsFTp	...............................shpGpWhNchGS..phpIp.....pssGtlsGsYhoslsps.t....s...ss.....lsGhh.................stssl..uFoVpW..........sphpShT..sWsGQshhs..supphlpThWhhspts.sstp...p..WtuhpsGtDhFs...................................	0	39	42	61
+1302	PF03377	Avirulence		Xanthomonas avirulence protein, Avr/PthA	Mifsud W	anon	Pfam-B_3936 (release 6.6)	Family	\N	23.10	23.10	23.10	23.20	22.30	23.00	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.43	0.70	-14.25	0.70	-5.74	2	801	2012-10-11 20:00:59	2003-04-07 12:59:11	8	12	45	7	116	807	9	173.70	53	73.42	CHANGED	LsssQlltIAppGGhpAlEsVpthhssLsts..sLT.tQVVAIASNIGGKQALETVQtLLPVLCQsHGLTPDQVVAIASN.................................................................................................u.....GGKQALETVQRLLPVLCQsHGLT.-QVVAIASN.GuKQALETVQRLLPVLCQsHGLTP-QVVAIASp.GGKQALETVQRLLPVLCQsHGLTPpQVVAIASNhGGKQALETVQRLLPVLCQAHGLTP....................................................................pQVVAIASpsGGKQALETVQRLLPVLCQsHGLTP-QVVAIASNGGGKQALETVQRLLPVLCQsHGLTPpQVVAIASN	.....................................................................................................................................................................................................................................................h.hlp.+.LhP..V...Lsps.HuLT.tQVVAIASp.GG...KQALETV.Q.R.LLP..VL.CQ.s.HGLTPcQVVAIASpsGGKQALETVQ.R.LLP..VL.CQ.s.HGLTPsQVVAIAS..N.GGKQALETV.Q.R.LL.P..V.L.CQ.s.HGLTP-QVVAIASpsGGKQALETV.Q.R.LL.PV.L.C...Q.s.HGLTPsQVVAIAs..psGGKQALEoV.p+hL.Ps....................................................................	0	5	22	22
+1303	PF03591	AzlC		AzlC protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.80	22.80	22.80	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.64	0.71	-4.25	162	3558	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	2883	0	690	2484	1687	141.30	28	60.12	CHANGED	lPl.hluhhshGlsaGllu.spsGlohhpshhhShllaAGuuQFlslsllss....uu...s...hhslllsshllNhRHllauholsshhp..t..hshht+hhhuahLTDEsaAlshs.phtp.ttttt.............hahhGhs..lh.hahsWhluohlGslhGshls	................hPlslualslGluaGl..h.u.spt.Ghohhpsh.hhShllaAGuuQFlhlu.llsu....uu....s............lhsls.loshhlNhRahLhuhultshhp....t..........hshhpp.hhhuahlTDEsaulshs.ph.sp..ppttt.................hahhGlsl.ssahsWshuollGuhhGshl............................	0	197	409	559
+1304	PF02216	B		B domain	Bateman A	anon	Pfam-B_1782 (release 5.2)	Domain	This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.	22.40	22.40	22.90	22.40	21.50	22.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.29	0.72	-4.20	6	1484	2009-01-15 18:05:59	2003-04-07 12:59:11	11	69	165	21	12	1155	0	53.40	62	43.70	CHANGED	ppspasc-QQNAFYplL+hPNLsEEQRNGFIQSLKDDPSpSppVLuEAKKLNDu	....s.sNpasc-QQNAFYEILphPNLNEEQRNGFIQSLKDDPSpSsNl.LuEAKKLN-u..........	0	8	8	12
+1305	PF04182	B-block_TFIIIC		B-block binding subunit of TFIIIC	Wood V, Finn RD	anon	Pfam-B_68239 (release 7.3);	Family	Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.10	0.72	-4.13	35	324	2012-10-04 14:01:11	2003-04-07 12:59:11	7	4	262	0	222	703	46	74.90	27	4.73	CHANGED	sshpaplLptIApsRhpGlhph-Ls.phss..pDsRslhh+hcpLpctsLIs+psl...................................ptpstposllhLp+Fhpp	.....................s..hpaplLptlu..p.u.Rh.pG..h..h.Qp...-Lt..phhp.....hDs+plhhph+tLpcpGLIs+psh....................................................................................................ptpt......tpo.t.l.lhLp+Fh..t...........................................................................................	1	65	124	181
+1307	PF02246	B1		Protein L b1 domain	Bateman A, Mian N	anon	Pfam-B_3438 (release 5.2)	Domain	Protein L is a bacterial protein with immunoglobulin (Ig) light  chain-binding properties. It contains a number of homologous b1 repeats towards the N-terminus. These repeats have been found to  be responsible for the interaction of protein L with Ig light  chains [1].	25.00	25.00	26.40	43.00	24.60	23.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.31	0.72	-4.15	3	19	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	2	23	0	33	0	69.50	78	44.52	CHANGED	TPE.PKEEVTIKsNLIFADGoTQTAEFKGTFAEATAEAYRYADLLuK-NGEYTADLEDGGYTINIKFAGK	TPE.EPKEEVTIKANLIaADGKTQTAEFKGTFEEATAEAYRYADhLtK-NGcYTsDltDtGYTlNIKFAGK............................	0	0	0	0
+1308	PF03483	B3_4	S3_4;	B3/4 domain	Bateman A	anon	Pfam-B_1005 (release 7.0)	Domain	This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.	23.30	23.30	23.40	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.76	0.71	-4.80	308	5864	2012-10-01 21:04:40	2003-04-07 12:59:11	12	45	4697	27	1517	4739	2917	167.50	30	24.80	CHANGED	ssspahu+.llcslp.hssSP.WhppR..LhtsGlRs.INslVDlTNYlhl-hGp.....PlHAFDhc+l....p.........s.plh.VRh.Ap.su....E.plhsL..Dsp.chpL.ss...........................stlV.Is...D......s......p.p.sl.ulAGlMGGtpSpls.p.........sTpslhlEuAhFsshtlttsu+phs..lpo-uShRFERG.lDsphsthAhccAspLlh-ls.G	...............................................................................................................sstahs+.h.lc.slp.hts.o....P.W.hpp+....L.hps....G.h.....Rs...IsslVDloNYlhLchGp.....PhHuaDh-cl.p..........................................G.slh..VRh.Ac..pG............................E.phs.sL..D.sp...-tpL...ss.......................................splV.Is....D........s.......................pp..sl..uluGlhGG..p.po.t.ls.p........................pTps.lllEsAhFss..h.s.lttp..u+.pht....lpo-.uu...RaE+G.l-..t.h....uhphAstLl.phs.............................................................	0	509	955	1269
+1309	PF03484	B5		tRNA synthetase B5 domain	Bateman A	anon	Pfam-B_1005 (release 7.0)	Domain	This domain is found in phenylalanine-tRNA synthetase beta subunits.	24.10	24.10	24.10	24.10	23.20	24.00	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.33	0.72	-4.15	85	4895	2009-01-15 18:05:59	2003-04-07 12:59:11	10	18	4795	27	1299	3944	2191	69.60	33	9.04	CHANGED	tptlplshpplscllG...........................h..plstppltp...hLpplshpsph....................spsthpVpsPsaR..hDlppphDllEElsRhhGa	......................................t...lslphscls+ll.G.................................................h.....cl.s.tp....p.ltc...lL.p+LGhp.lpt.....................................................sssthp.V.ssPoaR..hDl....p.h.ct...DLlEEVARlYGY..............	0	443	837	1100
+1310	PF01603	B56		Protein phosphatase 2A regulatory B subunit (B56 family)	Bateman A	anon	Pfam-B_984 (release 4.1)	Family	Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also Pfam:PF01240), this family is called the B56 family [1].	25.00	25.00	25.40	25.10	23.40	24.40	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.30	0.70	-5.87	54	1081	2009-01-15 18:05:59	2003-04-07 12:59:11	15	15	292	10	639	990	15	337.90	49	73.42	CHANGED	.L.P.hp.csssscppsLFlpKlp.CshlhDF.sD.....ssp-hppKch.KppsLp-ll-hlsss.p........stls-shhstlhpMlusNlFRsl.......Pshsp.t........hss---ps...hh-suWP...H...LplVY-lhl+alpssshssp.hptalspsFlhpLLsLFcSpDsRER-hLKshLH+lYuKFhshRshIRpsIsslhh.................calh.....csppasGluELLElhuSIIsGFulPLKcEHphFhh+sLlPLHpscslshYatpLshslspFlcKDssLsp.llctLL+aWPhosopKElhFLsElccll-hhpsspFpphhhsLFpplucC.lsSspFpVAE+ALhhWsN-tlhsLl.....p..pNsphlhPllhsuL.csucpHWNpsl+shshssh+hhh-hssplFpc.http......hpppppccpppp...pp+cppWpplt.chAt	.......................................................................s.hc.-s.sst-p.pLFhpKlp.CshlFDF..D.........................shtc............h+.KEl.KRtsLtEhl-al.......sps..p............shlsEshhschl.pM..h..........u..hNlF.Rsl...............................PPssssp..........................aDsEEDEP............slEsuWP...H..................L.Q.....lVYEh.....FLRFlpS..-hpsp......lAK+YIDp.pFV..L.....p.......LL-L.FDS.EDPRERD...aLKThLHRIYGK.FhshRuaIR+pINNlFh.................c.FlY.....ETE+aNGlAELLEILG...........S...II..NG..............FALPLKpEHK.FLh+lLlPLH..........KsK........s..........Lu..hYHs....QLu.Y.CllQFl.EKDspLs-................Vl.h..GLL+aWP...t...TpS.K..EVM..FLs.ElEEI.L-...l.....hc.P.........s.p....F........Kl..PLF+QlA+C.lsSsH.F.........Q........V.AERALah.WNNEalh.s...Ll.......................p..cNt...th...IL..PI.hFsuLh.cso+p.HWN..p.s.l.....huLhhNshKhFhE.hs.pLF--.hstp......aptcctp........tp....p...........tpRpphWtplp.p..................................	0	209	349	494
+1311	PF02043	Bac_chlorC		Bacteriochlorophyll C binding protein	Mian N, Bateman A	anon	IPR001470	Family	\N	25.00	25.00	28.60	28.40	24.90	17.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.79	0.72	-4.19	12	34	2009-09-11 07:33:55	2003-04-07 12:59:11	12	1	21	1	24	32	0	77.10	52	97.47	CHANGED	shuGAFopuAtAYGRhlEVFlDGHWWVVGDhLENlGKoTKRLssNAYPalYGG..uuuuul+GSSPphuGYApPoKclcpRFpc	.s..uGsFTchhuAhGRIhEVhl-GHW.sVG.hh-ulGKuThRlspNAYsphhGG....usuLRGSSPpsSGYAhPoKtlcS+Fs...........	0	4	5	18
+1312	PF00216	Bac_DNA_binding		Bacterial DNA-binding protein	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.70	0.72	-3.96	158	11816	2012-10-02 15:10:05	2003-04-07 12:59:11	16	10	4455	45	2522	6533	4975	89.30	37	83.62	CHANGED	hsKs-Llppl.........u.....pcs......s.l..o+ppspphlsshhctlppsL..ppucc...l....plsG.FGsFplpp...+tuR.pGRNPpT.G-.tlpl...ss+pslpF+suKpL+ctls	....................................................................MsKs-Llc..t.l.........A.........pps.......s..l.....oKp......cup....p.s.l-shhcs......lppuL....ppG-p........V................pL.h...G.FGoFpl..+c..............RssR...p....G..R......N...P....p...T.Gc..plpI....sAp..pVs..tF+sGKtLK-tV...............................................	1	797	1619	2112
+1313	PF00308	Bac_DnaA	bac_dnaA; 	Bacterial dnaA  protein	Finn RD	anon	Prosite	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.18	0.70	-4.70	14	6279	2012-10-05 12:31:08	2003-04-07 12:59:11	13	14	4628	18	1289	7863	4434	203.50	39	51.24	CHANGED	Lsp+YoF-sFVhGsSNchAaAAAhplAcs.Puc.tYNPLFIYGssGLGKTHLL+AIGNhshp.hP.shRVhYlsuEcFsp-hlculpc..schppFKcpYR.slDlLLIDDIQFlutKEpoQEEFFHTFNsLh-ssKQlVloSDRsPccLssh--RL+SRFphGLssslpPP-hETRlAILcKKhc....tcshs.....lPpElhpaIApplssNlRELEGAlpRlhsaushs	................................................................................p.paTF-.s.F..V.........G..p.......u.N.......p...h......A.....h..A..........A..u....h....t.....V....u................c............s......s.......u..t.....s........Y.......N...P......L......F..l.Y.G.u.s.GLGKTH.L...........hp....Al.G.......st.l........h..................p....t.t...........s.....s......s......+.V....h......Y......l....s..u....E.....p...F...s...p.......-...h.....l.p.....u...l....pp...........pt...h...p...p.....F.....+.......c....t.....Y...R.....s.......l...D....lL......L.I...D........D.........I........Q....F........l..........u.....s.......K.........-..........p..........o........Q.........E........E........F.F....a......T..F.N.....s......L......h.........c.....s......s........+.....Q......I..........l......l........o....S.......D......R..s.........P........+.................c...l.........s....s......l....-.....-.....R.......L....p..S.....R.F...s...W..G.L...s..s.sl...pP.P...-.h.Eo.....Rl...A....I.L.p...pKAc.......................t.p.slp...............lP.s.-V...h.pa.l...Ap.p..l....c...s...N.l...R-LEGALs+lhA.up..s................................................................................................	0	415	826	1072
+1314	PF01311	Bac_export_1		Bacterial export proteins, family 1	Finn RD, Bateman A	anon	Pfam-B_1442 (release 3.0)	Family	This family includes the following members;     FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal  peptides, through the membrane.  Although the proteins that these exporters move may be different, the exporters are thought to  function in similar ways [1].	27.80	27.80	27.90	28.60	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.37	0.70	-5.10	16	3358	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	2177	0	654	2099	515	239.20	26	92.63	CHANGED	pshhshlsthhLs.hhRlhshhhhlPhhspphlsuhlR..hulshhluhhlhssl.hsssshhsst...hhhLllpElllGlhlGhhhshsFhshpsAGplIDsQtGhsh.ushhsPssuspso.luphLshhulllalsssGhhhlls.slhcSaphhPlsphhs..t..thhthlhpthsplatpulhlAuPllhhLLLh-lulGlluRhAPQlslhsluhPlKshlullhlhlhhsslhshhppthphhhshhs	..........................................th.lhshhhs.hhRl......huhhhhhPhh.u.pps.l.P.s.t.l+....hsluhh.lsh..h.l.h.P....t.l........s..s..t....s..h....s..h...h.........s..........hh........hhhlshpElllGlhlGhhhphsFhsh.phAGplIshQhGhuh..uohh.DPs..s.u.s..s..s.s..lluplh...shhu.hllFl.s...hsG.........Hh.hllp.hLhcSaphlPlu.s.....h....h..h....s..s.............h........h.....hlhphh..shhahhulhlAhPllshhLlsslulGllsRhAPQLNlFsluhPlphhlGl..h.l...l...hh...h.h..shlhshhtphht.......t....................	0	202	393	515
+1315	PF01312	Bac_export_2		FlhB HrpN YscU SpaS Family	Finn RD, Bateman A	anon	Pfam-B_1200 (release 3.0)	Family	This family includes the following members:   FlhB, HrpN, YscU, SpaS, HrcU SsaU and YopU. All of these proteins export peptides using the type III secretion system.  The peptides exported are quite diverse.	22.10	22.10	22.20	22.80	21.30	22.00	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.85	0.70	-5.55	16	4381	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	2177	42	948	3009	756	267.10	32	91.14	CHANGED	.u.-KTEcPTsKKLcDARcKGQlsKSpDlsshshllushthlhhhushhhpcLtuhlth.hhhtspsashuhp.thhthhhhlhhshshhl...hhsshlsulhushlQsG.hlhoscul+Pchp+lNP..lpu...hK+.hFSsculhEllKSlLKllhluhlhahhlhsphsplhpLshss.tshhshshpLhhplhlhshhhhllluhhDahaQ+hpahKcl+MoKpElKcEaKcpEGDPclKu+RRphtpElt.ppphtssl.....cAsllVsNPTHaAVAltYc.pchssPhllsKGsDttALpl+phAcctslPllcshsLARuLYppschsphIPtphacsVAclLthlh	...........................................t...pKTEtsT.++hpcu+c.cGpls+Sp-...ls.hh.hhs.hhhh.h.h....h.h...h.............h....h.............t....h.....t...h....h.t...............h.........................................h......................................h..h.................h...h.............h...........h...h.h.h....h.h.h..h.h.hhs.hh.s.shh...s.G..hhh.sscs.l..php+l.sP..hts.........hKp..hF.uh.pshh-hhKslh+hhhlhhhhhhhh...h..thht.h..........s............t....h..h.hth.hh.hhhhhhhhhhhhshhDh.hpha.ahcph+Mo+p-l+cEhKptEGsPplKu+hRphtpth...........t...t....p...h.h.ttl.......pushllsNPT.Hh..AV.ALpYc....p....p.....s...A...PhVlAKGts.lAhpI+plAcc..pslPllcs.sLARu.Lapps.c.ls.ptIP..t..p..L..a..pAVAclLsal...........................................	0	309	593	767
+1316	PF05088	Bac_GDH		Bacterial NAD-glutamate dehydrogenase	Moxon SJ	anon	Pfam-B_6291 (release 7.7)	Family	This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to  ketoglutarate and ammonia [1].	23.00	23.00	23.40	23.00	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	1528	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.37	0.69	-14.31	0.69	-7.18	107	1221	2012-10-10 17:06:42	2003-04-07 12:59:11	7	6	1073	0	449	1248	467	1239.90	36	88.15	CHANGED	l+lhs....htp.tshpus.pollplls-DMPFLVDSlphtlscpulsl+hlhH.PllplcRs.tsGplhpltstst........................ssttEShlhlEl-.+hs...sspphpt..LpppLppVLsDV+tsVpDWpsMpschpph.hpplp...pp...................chpEstsFLcWLtscpFoFLGa+cYpl....................tss.thtlt......ssouLGlL+..........t.httspphsshssttttthhp.sph.LlloK.ustpSpVHRsuYhDYlGlKc.a...cppG...pVlGEpRFlGLaTSsAYspssppIPllRcKlppllppuGasssoHsuKsLhplL-saPRDELFQhst-pLhchuhullp.Lp-Rt+lRLFlRpD.asRFlSsLValPR-+YsTplRh+lpplLtcshsu.pts-asshh.sES.sLARl+all+h........sssph.......h-hpclEppltchsRsWpDclpssLhpp...........hup..............................tputtlhp+YssuFPtuY+-passppAltDlpplcpL.........ss..ssslshplY......+s..pss....sp..l+LKlap.tspslsLScllPlLENhGl+VlsEp..Papl....ph..t.....st.....pshWlaDFsLp..hssst.......hclsp.............hpptF...p-AastlWpGcsEsDuFN+LVLtAuLsWRplslLRAYu+YL+QsGhsaSQsYltpsLsppPsluptLlpLFcsRF..-P.........................................ttppcspptptlpsplppsL-pVssLD-DRILRpahslIpATLRTNaaQt.......st........pGps...+salSFKlcsptlsslPtP+PhhEIFVYSPRVEGVHLRsGpVARGGLRWSDRpEDFRTEVLGLVKAQtVKNAVIVPVGAKGGFlsKphPss.s.....sR-uhhsEGhtCY+hFIpuLLDlTDN..l.lsGc.........lVPPs..sVVR+DsDDPYLVVAADKGTATFSDlANulut-.YsFWLGDAFASGGSsGYDHKtMGITARGAWESVKRHFRE.hGlDsQo.psFTVVGlGDMSGDVFGNGMLLSccI+LlAAFsHpHIFlDPsP.DsApSasERcRLFsLPRSSWsDYDpsLISpGGGVFsRouKoIsLSsch+thLGl..cps......phoPsELIpAIL+APVDLLWNGGIGTYVKAosEocu-VGD+ANDulRVsGp-LRsKVlGEGGNLGhTQhGRIEaAhpG.....G...........RlNTDhIDNSAGVDCSD+EVNIKILLsplVpsGcL.ThcpRNpLLtpMTD-VupLVLcs.NYtQopAl..SlsptpuspplstptRhhptLEppGpLcRtlEhLPs-cplscRtstGp.GLTRPELAVLlAYuKhsLp-pLlsS.-ls--s......ahsphLhsYFPp.Lpc+assp.ltpH.LRREIIATtlsNplVNchGh.....sFlhRlt-pTGsss.sclscAashucclFslsslWppI-uLD.splsuslQhphhhplp+hlc+sspWhLRs...ppt....h.s.lsstlspapsslppLp....splsshLsspp..tpthppptpphsp.tGlPpsLApplAslphhhssl......DllclAppssts........l..tplApsYFtluppLslshlhptlsp.lsssspWpsLARt.....uhp--LtttpRpLstslLpt............t......spttlstW..hppppstlpRhpphls-lps...sssh-hAhloVAhRpLpsL	....................................................................................................................................................................................................................................................t..hshlpll..shPaLlDSlhh.ltp..shthph.hhp.s..htltRt...pu....tl.tl...................................t...pohhhlpl.........s...t...........sttthtt...lpptl.phLtplt.sspDh..hhtth.th...httlt....tt................t.....................pht-shthLpWlt.sppFhhhGhpchth.......................t....t..h...........tstLGlhp.................................................th.......h..p.......l.hlsK.ss..Shl+R..ssY.Dalul+.....hstpG............t.hhuEpRhhGLasussattss.pIPhl+p+httlhthu...uht...tuash+tLhpllpphPR--Lhphs.ppLhthshsllt.htp.+.ph+lhlRh......D.hs.+FhssllalP+-casoth+.thtthlhp.htu.t.h.-..hshh..s-.uslsphphhlch......t.tt...............t..hs.....ttlptplhphspsWpDph.thh.tt...................................................s......tphttsFs.sY+pthsstpAlhDlthlttL................................st.....p...lth.hh.p....ts..t..............tt.........hphKl....ap.tttsh.LSplhPhLpshGlcVl.sEp..sapl.h.................ps.........t.h.alh-Ftht....t...............hp.h..t.p......................ht.tthppAhtth.atG.p.h.EsDsFN.pL..lhtAuLsh+pl.slLRuhu+Y....l.....+Q.h.....u.h.....s.....aSpsYl..tp.sLp..p..aPp..l..sctL.lpLFpt+F.....sP................................................ttptpppptp..t.l....t..p.p...ltpt.L..-...p.V......s......s......L.D....-.....D.R....I..L.Rpah...sll.pA.oLRTNaaps....................t.................t....s....+shluFKhcP........ph.....l........s........p.l.....P......t.......P....p.......P.haE.....I.F.V.Y.u.PclEGVHLRhGtVARGGLR..........W.......S......D......R.p...ED.........F.......R........T..........El.......L.GL.......V....KAQtVKNsVIVPlGAKGGFls+p..P.s..s...........................sR-thht.cGh.tsY+h...F..I.puLLDl..TDN......l..h....p....up..............l..VsP.t..p..V.VRa..D.tDDsYLVVAAD.KG.T..A..T.FSDhA..Nslut.p..as..F.WLGDAFASG...G.S...s...GY....DHKtMGITA+GAWEuVpRHF+E.hG.....h......DhQ.s.psFTslGlGDMuGDVFGNGMLLScpI+LlAAFsHhHIFlDPsP.DsttSatERpRLFpL.PR.SSWtDYstpLIStGGGlasRstKsIslosphpthLslpts..........................phsPs-LlpAlLpu.VDLLWNGGIGTYlKuspEocspVGD+ANDslRl.sup-lRs+l..lGEGGNLGhTQhGRlEauhpG.....G...........+lNTDhlDNuuGVDsSDpEVNIKIhLs..th..l.t...........sGcl...s.p....pR...spLL.pMoD-VuplVLts.NhtQs.s..l..uhstt..puhthht..tchhp.LEpp.s.h.L.sRtlEhLPssppltcR....t......t..G..sLTpPELulLhuasKhsLtctllt.o.pls-...-s......hh.sp.L.tYFPt.....lp.pp...aspt.h.pH.L++EIlsT.lsNphlsphGh.....sah.Rlt-psGts..splhpsahhscplatlstlhpplp.t..L..s......lss.................thp.phhhthtchhpcsspWhLpp.....t.t.........s.ltt.ltpat.thttlt.....phsthl.....t.tp..htthptthtthhp..tGl.sttlAthluth..hhs.hh....sI.hpl......u.p.......ts..hs.........................h.ttsAchYatlupthththh.....hpthpt...s.hsshWpshAttshp--l....ptlshtsLt....................p.............tt.ht.W....t.t.pt..ltph.thltphtt.....tt.......h...phshhsls.t.h..........................................................................................................................................................................................	0	153	284	373
+1317	PF01152	Bac_globin	Globin;	Bacterial-like globin	Finn RD, Bateman A	anon	Prosite	Family	This family of heme binding proteins are found mainly in bacteria. However they can also be found in some protozoa and plants as well.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.47	0.71	-4.10	12	2140	2012-10-01 21:46:00	2003-04-07 12:59:11	16	28	1468	69	809	1739	270	116.80	24	78.59	CHANGED	ola-tlGGpss.lcslsscFYspl.sDsp..htphhp.sschsspcp+.htFLsthLGGPshYht+pG+P.L+tpHtsh..slsstch-thlcphtpAlpshs.tshs.-phhchhphhttshhsh	...................a-hlGG....pps....lpplV-pFYs.t.l.tpDsp.................lt.h...F..t......s......s......-...h...s..........p....t...pp+...h...t...p...........Fl...st...h...h.....G..G..P.......s..h.Y....s.t..p..p...........G...p........P...........l....+....t....p.H..h...sh........sIst.tc.h-tWLpp...hpp.A.l.s.c.h...s.h..s..t.t...h...tp.....l...h.thht.htt.h...t........................................................	0	348	595	732
+1318	PF00296	Bac_luciferase	bac_luciferase; 	Luciferase-like monooxygenase	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.70	0.70	-5.30	155	15488	2009-09-11 11:56:34	2003-04-07 12:59:11	15	68	3031	48	4888	13559	5534	299.40	18	82.83	CHANGED	h..........hhh...phth.h.st.................shpphhchAptA..Eph.GF-shhhs-phts........................h-shshhuslA.stTp+lclssultssh..p....pPshlAppsATl-.plSs......GRh.tLGlGs.Gttthp...hthh.....Gh.........shscphsthcEhlcll+tlh....tt......................pps.sacGca..hph...........................tpshhhPps......................P..lhluutu.spshchAuchuDshhshs..............ts.sthtphhsplcp.tstp...........tGRs.....shphsh.thhlhhs....cspppAtpth......hthh.........................................................t..thtthhthh..tthhtshsh...lG.osp.pl...tcpltp..htpsGssp	...................................................................................................................................................shpthhplApt..A..E.......c.........h..G.a.cthal.s..-pht.h.........................................ss...hsh..lut.lA.s..t..T..p.......+..l....c..l......u.s..ush..hhs...p........sP.h.hlAcp.hu.oL.D.plos...........G......R.h..tl.s..l.....u....s....G.........t..t..t....p.........hpt.h........Gh.........................sh.s.p.p.h.p...t.h...p..E...h....l..p...llp.p..lh.....ps............................................t.h...sa....p...Gca....hph.......................................tssth.h.P.t.shpt...............................hP...lah.u.u........s..u..s.............t..u....h..p.h..AA.c..h....u.p.shhhss....................s.p.t..h.t.p.h...h.p.t......h.+p....th..t.t...............................tG+..t.........phph...h.....h...th....h......s...hs.s...............c..s...p..p..p..A.hthh.............tthh............................................................................................................................................h.......t.....h.........................................h..t.t.hhh..................lG..ssp..pl...tptltt....h.t.....t...................................................................................................................................................................................................	0	1231	3130	4170
+1319	PF01036	Bac_rhodopsin		Bacteriorhodopsin-like protein	Finn RD, Bateman A	anon	Pfam-B_1412 (release 3.0)	Domain	The bacterial opsins are retinal-binding proteins that provide light- dependent ion transport and sensory functions to a family of halophilic bacteria [2,3]. They are integral membrane proteins believed to contain seven transmembrane (TM) domains, the last of which contains the attachment point for retinal (a conserved lysine). This family also includes distantly related proteins that do not contain the retinal binding lysine and so cannot function as opsins.  Some fungal examples are: Swiss:O74870, Swiss:P25619, Swiss:P38079, Swiss:Q12117.	21.90	21.90	21.90	21.90	21.30	21.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.64	0.70	-5.04	17	3174	2012-10-03 04:04:29	2003-04-07 12:59:11	13	10	618	161	242	3093	2566	141.90	35	89.93	CHANGED	hshaslhulhhllushlFhhhshp.sss.p+phhssslhlsultuhuYhshA.slGhohsts..................cpla..hs+YlsWhlohPl.....lLhLs.lAsss...................tpslhshlhsshlhllshLlGulh..sush.....+asaashussshLhlhYhlh.sshtpsstshspp...shahhLp.hhlll...WhhYPlsWhlustGssl.sssspslhashLDllshlsashlLlhttsshsstt	.......................................................................................................................................................................................................................................................................RYlDW....LlTV.PL.........h.hh....l....l...Ls...t...l....s...s.ss.................................................sul...h.a.+....L..l.h.uS.ll.MLls.G.Yh.G...E.......s........shh.s..............sh.h.h.a..l.l.u.h.h.u...alYI..l.Y.p...l...........a..G.....Es.u....c.s..u.s...p..u..u.ss.s....tsAasshph...lVhlG......W.u.lYP.................................................................................................................................................................	0	69	151	216
+1320	PF01103	Bac_surface_Ag	Bac_suface_Ag; 	Surface antigen	Finn RD, Bateman A	anon	Pfam-B_1201 (release 3.0)	Family	This entry includes the following surface antigens;    D15 antigen from H.influenzae,    OMA87 from P.multocida,    OMP85 from N.meningitidis and N.gonorrhoeae. The family also includes a number of eukaryotic proteins that are members of the UPF0140 family. There also appears to be a relationship to Pfam:PF03865 (personal obs: C Yeats). In eukaryotes, it appears that these proteins are not surface antigens; S. cerevisiae YNL026W (SAM50, Swiss:P53969) is an essential component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The protein was localised to the mitochondria [3].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.90	0.70	-4.97	70	6186	2012-10-03 17:14:36	2003-04-07 12:59:11	18	36	2849	0	1843	5261	3202	320.30	19	47.88	CHANGED	NhhGpGpplshshs..............hu.............p.hppshshsaspP...ahhsp...............thshuhslhhp......................................t.st.pshshpshuhslshuh.....ls.......pphphs.....huhshppsphpstssps................................................................tttpstththshuhshsshssth.hPopGhh............hphshchs.....................h..huussp..ah+hpsps.phahsltp..pt.hhh.......hs+hphGhht.ths..................stc.lPhhcpFasGG..........ssSlRGaphsslGPps...............................ptt.lGGpthhsuShEhphPl.h.....t..t.hpsuhFhDsGs..............sassptpss.......................................psusGlGlpWtoP.hGPl+hDaAh.Pl....pc.ss.sp.................pp.papFulG.ppF	...........................................................................................................................................................................................................................h.utGp.phshs.hp.........................hs.................t...ppth.phsh.p.P............hh.h.s.p......................................t.h..ph.s...h.shhhp..................................................................................................p.....sh..s...t..p......s...h.u..h..s..h.shsh....................hs.................................p..t..h.p...hp.......................................hs.h..s..h...p..p....s..p..h.p..p.h..p.ps..............................................................................................................ps.h.h..h..s..h..s..h..s..hs..h......s....p...t...c......s........s....h...h.....P....s...p...G.h.............................................................hph.s.hchs........................................................................h....h.u...u-.sp.......ah+.h..ph..ps...p.h.ah.slsp...........tpthsh.............................................hh+s..phG..h...ht..shs................................................st.p....l.P....h....p.p.....F.a.s..........GG...................s.p..o....l..R.G..........a.p...p.s.l.uPpt..............................................................................ttt..h...G.G.s..t..hh.su..ohE.....hp..h.....s..l...................tt..p....hp.....s.uh.F...h....D......sGs.....................................l.h.s.....s..t.t..p......s........................................................................................................th+h.usGl.G...l..pa.......h.......o......P....h....G......P.....l.p.....hs..hAh..sl......pp...pt..t..............................................tt..th.hslG.t...............................................................................................................	1	578	1140	1548
+1321	PF01338	Bac_thur_toxin		Bacillus thuringiensis toxin	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	26.00	26.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.51	0.70	-5.12	7	74	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	26	16	17	68	0	187.60	43	89.80	CHANGED	pps..ppshRhIhLpV.ss.-.ssh.pIh.lp.Ppal.QAltLAsuFQsALsP........sLpFshpKuLplAssl.Ppuul.VshlsQolpQosspVSVMls+VlElLpsVLGlsLsuosh.pplpsuITsTFTNLssQps-AWIFWt+poAppTsYpYNIlFuIQNtpTGuhMhslPluFEIsVslpKcpVLFhTI+DpAsYpVplpuLplsQsL.pppthslhsl.pshs.sh	...............................................................h....................ph.pl..lp.spYl.QAlhlsssFQsAlsP.........sLpFsh.KuLpIANsl.PtuuV.luhlsQsVhppsspVSVMIsplhE.ll+..oVL.......Glslsu.ush..splsuAITNTFTNLssQpsEsWIaW..tpp..o.A..sQ.TsY.pYslLFuIQ.NppTGthMhhlPluh-ls.V.sht+pplLh.hsh.psptpatVphpth..........................................................	0	1	6	12
+1322	PF01654	Bac_Ubq_Cox		Bacterial Cytochrome Ubiquinol Oxidase	Birney E, Bateman A	anon	Pfam-B_1148 (release 4.1)	Family	This family are the alternative oxidases found in many bacteria which oxidise ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II	26.20	26.20	26.50	26.80	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.47	0.70	-6.07	178	4711	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	3032	0	940	3110	321	447.50	39	93.87	CHANGED	LuRhQFAhTssaHhlFsslTlGLuhhlslhE..shaltTs.........cph....Yhchs+FWsKlFulsFAlGVVTGlshpFQFGsNWutaSchlGslhGssLAhEsLhAFFLEusFlGlhlFGWs..Rl.upthHhhushlVAlGoslSAhWILsANSWMQ.sPsGa..ph...............ps..G+hph...ssahsl.............................lhNPsh.h+asHslhAualouuhhVhGluAaaLL+.............................tc.....ch.....p.hh+....+uhphuhhhullsuhhtlh.sGDhpGhpshcpQPhKlAAhEuhW.-...T............ps......s..A....shslhulPsp...csp...c.......spat.lpIPhhhSlls...................s..+shsu.pVt.GLp-....................................................hst.........................................................................p.hP.s.VshlFauFRlMVGlGhhh.lhluhhuh.....ahth.+..................................p+ahLthhlhshPh.salAspuG.WhssEhGRQPWsVaG................l.........LpTspul.Ss...lsssplhhSLhsFhllYs.hLhs.stlhlhh+hh+....pGPps	.....................LuRhQFAhTshaHalF.lPlTlGLuhhlAlhEslal....hTs................cph.........Y+....c....hs....+....FWu.K.lF.u.I.NFAl.GVsTGlsMEFQFG..T..NWShYSca....VGDIFGs...P.LAhEuLhAFFL.EuTF.lGl.ahFG.....Ws..R...l.....s+hh.HhhsTahVAlG..oslSAhWILsA.NuWMQ.sP..sGh...ch..............................................c..s...h..R..h..c..h....ss.ahtl.........................................................................................................lh.NPsh.s+Fs.H.slsuualouAhFlhuluAa..aLL+........................................................s+.........c.h........s...ht++.uht.l.uhhhuhhuslss.hl.hGD.tpGhphtch.QPhKlAAhEuhWc.T.....ps............s..A...shslh......u.h......Psp.......cpp......c....................spau..l.pIP..h.hL.ullu.....s..+.o..h..ss....V...GLc-........................hst.......................................................................................................................c.thP.s..VsslFauFRlMVuh.Ghlh..lhlh....hh.uh..h.hhh...+...pcl...p......................................p+WhL+hslhshP.h.salAlpuGWh.ssEh..GRQPWslhs..................lL.TtsAs..Ss....los.upl.hh..Shlhas...slYs.llhhs.t.la.lhh+hh+tGPt.s........................................................................................	0	271	564	761
+1323	PF00936	BMC	Bact_microcomp; Bac_microcomp; 	BMC domain	Finn RD, Bateman A	anon	Pfam-B_1071 (release 3.0)	Domain	Bacterial microcompartments are primitive organelles composed entirely of protein subunits. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure [1].	20.60	20.60	20.60	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.50	0.72	-4.30	128	7283	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	957	198	954	3181	404	77.20	31	65.78	CHANGED	pAlGllEs.puhssulhAADthlKuAsVcllthctss..u.G..........hhhl.hlsG.DVuuVpsAlcuuhpsspc.h.........llsphl....l....s..ps	.............pAlGllps.puh.ssul.AADshlKuAsVpl.ls.hcphs.....u..G..........hshl.hlpG.DluAV+uAlcAusssspc.................lhs.hh.h.............................	0	418	700	840
+1324	PF02397	Bac_transf	Bact_transf; 	Bacterial sugar transferase	Mian N, Bateman A	anon	Pfam-B_1538 (release 5.4)	Family	This Pfam family represents a conserved region from a number of  different bacterial sugar transferases, involved in diverse  biosynthesis pathways.	20.40	20.40	21.10	20.40	19.50	20.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.31	0.71	-5.18	461	7019	2009-01-15 18:05:59	2003-04-07 12:59:11	11	45	3624	0	1678	5749	1907	186.40	39	54.00	CHANGED	KRhhDllhuhls.LllhuPlhl.l.lAlhl+l..ss...GP.lhFpQpRhGhsG+.....FphaKFRoM.hs...ss..-pt.............hptth........................c.sDs......R.lTp.lG+FLR+TS..LDELPQLaNVL.+G-MSlVGPRP.h.....tpsc...ph..h.s.....thttR.hpV.+PGlTGhAQVs....tpssh.shpp...............+lchDlhYlcshS.....lhhDlpIlhpTlhsll...h.c..GAh	...................................KRhhDllhu.h.lh..L.l.l.h.u.P.lh.l.l.l.u.lhl+l........s.t.......G.PlhFp.Qp.RhGh......s.G+...............Fp.laKF...RSMts..ss.....-pt........htp.hh..........................................................................p..s.Ds..R..lT.+........lGcFlR+TSLDELPQl.hNV.L.+G-MSlVG.PRP.h.s.........pt...h...c.....p...a.....p..................................phht.R.hpV+PGlTG...hAQls...........spssl..s.hp.c..............................+lc.hDlhY....l...c...p.h.S......lhhDlcIl.hpTlhhlh..t..p...t...........................................................	1	576	1136	1441
+1325	PF01721	Bacteriocin_II		Class II bacteriocin	Bashton M, Bateman A	anon	Pfam-B_1954 (release 4.1)	Family	The bacteriocins are small peptides that inhibit the growth of various bacteria. Bacteriocins of lactic acid  bacteria may inhibit their target cells by permeabilising the cell  membrane [1].	21.10	21.10	22.20	25.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.91	0.72	-4.43	19	138	2009-09-13 12:44:13	2003-04-07 12:59:11	13	3	75	11	5	112	0	35.30	47	58.83	CHANGED	KYYGNGVaCsKcpChVsWGpAhssIsstsssuassG	.+YYGNGVYC.s.Kpp..ChVsWucAhssIushshsuahsG...............	0	2	4	4
+1326	PF04798	Baculo_19		Baculovirus 19 kDa protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6291 (release 7.5)	Family	Family of Baculovirus proteins of approximate mass 19 kDa. 	25.00	25.00	28.20	34.00	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.93	0.71	-4.81	23	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	60	0	0	60	0	142.40	44	76.49	CHANGED	hhNPapphsp+LlcsatsoLpaGsaIcVaDhp....cs-RLFlIcPENlllYNssGsLYYYLE..uSuhhCP.sEFulVRFopsDIpsINEoGhashsCTslsSLsLlEHFho..ssls-tplhLs...p.phpaoIlDlINhLIpsGYlplp	...............h.hNPappphppLlcDatsTLpaGs.YIclYDLSsss.csERLFlIcPENVlLYNhsGsLaYYLE..SusVhCP.sEFulVRFops-IpslN-oGlasssCTsVsSLsllEHFhoLKNslsDppllLsh.....c..pIpaoIlDlINaLIhpGYVpl......	0	0	0	0
+1327	PF04631	Baculo_44		Baculovirus hypothetical protein	Mifsud W	anon	Pfam-B_5343 (release 7.5)	Family	This family includes several hypothetical baculoviral proteins, with predicted molecular weights of approximately 44 kD.	25.00	25.00	29.90	29.20	17.30	17.20	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.35	0.70	-5.84	23	108	2009-09-10 23:58:53	2003-04-07 12:59:11	7	1	82	0	0	99	0	265.80	44	92.09	CHANGED	LlllllllFLallY.pPlapAatpI+psQtpYspplD-ph-hhppsLpRRRYVPLcsLPslcasoshsTlst.Gph+ChSVPlhVosscTssFDCoplCDNssAsYFFVspaD+FVVNGphLspGGYCTTNSlPRNCNRETSllLaSlNQWTCIAEDPRYFAGpsNMlQlAGRQHuscIhPuplc+NVLaD+LLstpVslopNTFRpsWDElhpDGo.RRFEl+Cs.ALD.+pNpMFVNPlNPIECLPNVCTNVpaVHpsVRPsFEsG.C-CGDhslTRVpHlsssD+TShCASIVDphcpsstSa.......pFRV-ClshDoPlocasts..+LLCPsclFspNTDsAYsFsLsGs.hPlSuNGIcEPTaRhahDTRsR.lsass	......................................................................................................h..LPslphssp.hsphst.....st.cshp........sshhl.u..p....h....s..shD..CstlCssssu..hhF...alsp.sp..hVlNsphLt.GGaChssSlsR.CN.hpTS.hhlholspapCluEDPRYaAGstNh.QlAGRQH.spIhsup.s+NlLaDpLLstpVssspNTFRp.pWDEhh.DGo.RRFEh+Cs.AhD.ppN.MFlNPhNslECLPNVCT.s.VphlH.sV+P..sF..-...s...G......C-CG..t.hch.p......tohCssh....hp.................h.....Chth...h..h...............................................................................................................................	0	0	0	0
+1328	PF04786	Baculo_DNA_bind		ssDNA binding protein 	Waterfield DI, Finn RD	anon	Pfam-B_6251 (release 7.5)	Family	Family of Baculovirus ssDNA binding proteins.	25.00	25.00	44.80	43.80	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.59	0.70	-5.23	21	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	55	0	0	62	0	244.20	27	81.91	CHANGED	Wh-phlaNL..pp.tNhollpCsssh..NpLtcsLshlppphsl..pahcchhP....pht..cplslhcPp..ss+lsYplGhpV+GGhhs.FYaFDhspl+Rscu.saGcFlolpWsshhhHNplauplhtpah....thp.-.thpLpssshlslPpc.........p.sp+pshlRKFFslppcpNpplYsTGc.....L..hctlpscPaoh-cFcplFphp.scs....sScEVpMlhuulI-GhKpuKp-hphco.lss+clpEKsYSLAl+PhlFhplE	............................W.cphhhNL...pp...tN..hollp.Csss...ppLpcpls.lpphhsl..phhcc.hhP........p.s...pplslhcsp..ss+ssYplGh+lcGssps.FaaaDhsplK+scu.sa..G.cFhslpasshttaNplauplhtpah.....t.ppc.slplpsslhlslPcc...........sp+phFlR+FaslpppsNtplasTGc.....l..scs..lpspshol-cFcclFphptspp....sSpEVcMlhsuhI-GlKpuKt.-hphps....lss+chp..EKsYSLulKPhlFhhlE..............	0	0	0	0
+1329	PF04639	Baculo_E56		Baculoviral E56 protein, specific to ODV envelope	Mifsud W	anon	Pfam-B_5446 (release 7.5)	Family	This family represents the E56 protein, which is localises to the occlusion derived virus (ODV) envelope, but not to the budded virus (BV) envelope [1].	20.60	20.60	20.70	28.60	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.66	0.70	-5.76	25	71	2009-09-10 14:49:23	2003-04-07 12:59:11	7	1	62	0	0	66	0	286.80	48	84.53	CHANGED	ssPoohsl.ussphhPGYslsNspFVSsu-...lNplhRNNDlsulRplFss.sossQlNGLspLRRuDNlPDAslHuhphR+suVKssaPc.TssRT.pGVpsuLspNPRLssYL...KsAGhssLlGsGVYLlhsuAsLV.pDIlcALNRTGGSaYhpGpNGG-...sl-uClLpaRoCshshssl...ssslC........shDPLLss..spLpslCpGYNaEsEpoVCRuSDPNA-PsS.QYlDIS-LsssQTIpClEPYDhGDLIGDLGLDaLLGEsGllspSSNuSp....SlSssLhPlIllIGullhllhIGahIaKhlhppps	........................................sPoohsl.uNsphhPGYslsNNpFlSsu-...lNplhRNNDlsslRplFss.ssssQlsuLspLRRsDNlPDAslHutphR+suVKpsaPp.TssRo.pGVpssLppNPRLssYL.shKsAGhssLlGsGlYLlhsuAoLV.tDIlpAlNRTGGSYYhpGpNGG-...sh-sClLhhRTCths..ss...tslslC........shDPLlss..spLpslCpGaNa-sEpo...VCRuSDPsADPsS.QYVDIS-LsssQTI.ClEPYshGDLIGDLGLDtLLG-.cGLlspSSNsSp....SlSspLhPlIllIGullhllhIha..hlaKhlhp..s....	0	0	0	0
+1330	PF04850	Baculo_E66		Baculovirus E66 occlusion-derived virus envelope protein	Mifsud W	anon	Pfam-B_4624 (release 7.6)	Family	\N	25.00	25.00	113.00	112.00	19.10	17.80	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.41	0.70	-5.47	28	75	2012-10-02 15:11:41	2003-04-07 12:59:11	7	2	51	0	0	75	0	381.70	37	56.26	CHANGED	cssVNhpslppuIphVuSscGllNPAlhSRNGopaS.sVIGpFl-Ys.uVaSADaSKVLThhocpYaGSVVGsTsclAY.....YEADssNshaAPLWAMsRRIWscs...utllsY...p............spolshESGVlL.pshsGl............hslPo.....TssSTpSFpPslupT.AlspTcssG.AMlsau+FsELN.LEFcShTLYacpGMaQLY.pltshpsshss.....suRsVVLsRDh....s.pTs.-.sas.......suSs.stoaNGVss++hsIsNh...slsshslR.s.sslp..............hlEQlIuh-slpsGsGssCYpLsVps.....sDsspshplssssh...................hhhssssslcslFcFPal.hlK-spptplo.sstsst...........lshsslpplLshlshsstsl..hss..ptssssFhhpss..s.QFhFch	...ssVNhpNlppuIphVGSscGhlsPAlhSRNGopaS.sVlGpFl...-YssuVaSADaSKlLTlRocpYaGSVVGtosclAY.....YEAD.sNshHAPLWsMTR+IWsps...utllsY.p.................................sss..lshESGllL.pshNGl............hplPo......TssSTpSFpPsluhT.AlssTc.suG.shh.au+FsELN.LEFhSYTLYacpGMFQLYspI+slpshsss......uRCVVLsRDh.......s.sss.-.sap............ssSN.htsaNGVss+HaNIs.N.......slssFslR.shssls..............hlEQIIuhcslNsGsGsuCaoLhsps.....sDsspsh+lssssh..................hlhhsssssl.cslhsFPal.llK-spspplohssssst....st..H..lshspIpphLshlshsstsl..hss.hpc.psssFhhpss.tu.QFpFph...............................................................................................	0	0	0	0
+1331	PF03258	Baculo_FP		Baculovirus FP protein	Mifsud W	anon	Pfam-B_4275 (release 6.5)	Family	The FP protein is missing in baculovirus (Few Polyhedra) mutants [2].	25.00	25.00	26.10	26.10	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.20	0.70	-5.22	12	67	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	56	0	1	62	0	186.50	49	94.67	CHANGED	M-...ppLINVslLKsLIKsEIDcsVo-NIphlssKLK+LEc-pLNDoVEIYGIHDsR.LhsKKIRs.YlKKICuLLsL-aKtVl-SsacKNHIhV+LsDAsTA+EWQo+SREhRLKNaDLsI-aDGPVKIFVAAosEHK.LLKKTRDALLPaYKYVSLCKpGVMVR+s-+S+laIVKNEpDI.pLlsp.hpuhcsts......ts.t..t......pplI	..............................ppLINVslLKsLIKspIDcsVssslphhstKLK+LEpcpLscoVEIYGl+Dp.R.L.hsK.KlR.s.YlKKI.CsLLsLsaKtVl-osa...cKNHIhlKLsDAssA+EWQs+SREhRLKNaDL...........s..I..-a.D..GPVKIFVAA..osEaK.LLKKTRD.ALLPhYKYlSlCKpGVMVR+s-+S+laIlKNEpDIp.Lhsp...th........................h.................	0	1	1	1
+1332	PF04700	Baculo_gp41		Structural glycoprotein p40/gp41 conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4278 (release 7.5)	Family	Family of viral structural glycoproteins [1].	23.10	23.10	23.90	188.30	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.25	0.71	-4.86	21	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	57	0	0	60	0	190.70	50	57.94	CHANGED	sKRF-SD-pLIcaYtpLpKchsssshsp......sIFpsSFVhS.lh.uYApKFYs+........plsEAAcpLS.ulpYQlApAVTpNpPlPLshspplsN-YlpLLhp+AsIPsNlppuls.....sps.spLN....hhssllNsll-DlFsG.tssYYh.hsLNpcsRu+VhshK-NIuaLs...P.Lot..SssIFpaluphATpsG+	...sKRF-SD-sLIcaYtRLpKELGssslsc......sIFpsSFVhs.lLPuYAQKFYN+GuttlutsulsEAA+pLuhAlQYQlApAVTsNpPIPLPFspQLuNsYlTLLLp+AslPsNlQpulp.....SRphs+lN....hIN-LINsVIDDlFsG.uusYYh.YVLNEcNRARlloLKENluFLA...P.LSu..SsNIFpaIApLAT+uGK..	0	0	0	0
+1333	PF03273	Baculo_gp64		Baculovirus gp64 envelope glycoprotein family	Mifsud W	anon	Pfam-B_4223 (release 6.5)	Family	This family includes the gp64 glycoprotein from baculovirus as well as other viruses e.g. Swiss:P28970.	19.70	19.70	20.70	19.80	18.10	16.90	hmmbuild  --amino -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.87	0.70	-6.33	6	42	2009-09-11 04:57:11	2003-04-07 12:59:11	8	2	26	1	1	43	0	366.50	45	89.09	CHANGED	EHCNAQMKoGPY+IKsLsIsPPKEoLpKDlpIclsETDhsENVlIGYKGYYQAYAYNGGSLDsNTplpEsLhTlsVuK-DLLMWGlRQpCEVGE-LIDpWGSDSpsCaR-.sGRGhWV.....sGKELVKRpNNNHFAaHTCN+SWRCGVSTuKMYTRLpCss-oD-CpVpILDINGssINVotscVLH..RDGVSMILK.pKSchoRRopKlACL.........lKDDKsDPcoVTREH.........CLl-sDIFDLScNpWhCKFN+CIK....R+sEpVVKpRPpTWR+Dt.sKacEGs..oATKGDLMHlQEELhYENDhLRMNlELLHuHINpLNNhhHDLlsSlAKlDERLIGNLMsNSVSSTFLSDDTFLLMPCTsPPsHTSNCYNNSIY+EGRWVuNoDooQCIDFsNYcELAID..DDlEFWIPTIGNTSaH-SWKDASGWSFIAQQKSNLIoTME.TKFGG+sTSLpDlsshupGpLsupLtShhhGphhsalllhsVIlFLhCMlRstsR+	.....................................................................................Noth.t.h..hs.ttt-LLhWu.pppCphG-phh...DpWGSDS.sCht-..stt.Ws.tKELV+RpsN.+.FAaHhCNhoWRCGloTochas+Lpss.....sD-s..p..VhhL..sGssIslotspsLa..ccshShllK.ppophppcphKluCh.........htss.sDPc.lst.-.+..........Ch.sssha-lopspa.C+.stCh+.............cc.t..s.p.+P.pa+hs...c...h...sAohtDlhpl.ppLhYE..s-hL+hslp.hct+hsplsshhpsLl.SlAKlD-RLIGpLhspssuSpalsscpFhLhPChps.s..tsSNChssslYp-GRWsts.sDsspChshtt.p...lc.....hphhhs.ltsssh+tshpDtpGWSFlAppKpsLIpTMp.T+.GG.sTSLpslhths.G.h.tph.u........hhlhhhhhhhhhhhhp.....t...............	1	1	1	1
+1334	PF04735	Baculo_helicase		Baculovirus DNA helicase	Mifsud W	anon	Pfam-B_3393 (release 7.5)	Family	\N	25.00	25.00	116.10	48.10	18.20	17.80	hmmbuild  -o /dev/null HMM SEED	1173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.23	0.70	-14.16	0.70	-7.20	25	73	2009-09-11 13:37:16	2003-04-07 12:59:11	7	2	60	0	0	73	0	1095.40	37	98.75	CHANGED	tIhssIhpshp...pp-phsssshsss-pllh+Nssot..p++hlcsh-sFpKLlsshssptsts...........................t............ptt..h..........................tsHsWshpsNhF.shhV+PFlhtccY-p...lpcplshpcFhsopssthuNcCspuG-YhYWPN....hulsahGWplYLphpasIclsspIPLlHN+cLGsVNLFs.sschFLslEhsl.ssps..ppLFVNG+othscp.p........-cLFplshs....ssssusCKhsscLVaS.NKshFcYl+D-INLppChssscY+pllc.lDLpsLRhFsstt..sssslsst-ct..........pspppITPSSEptcpIpppIc-ClphIpEsMhcshspp-pucs..lLppYhppSsFhNFcYLIlslW+hlp+spch...pascTDI+LFlELLC...........Eplaus............ct..thcpshpcCcPYhphosplap+FCsphshFsssss.....h.uLutYaAIHahIYtKpss..........WsaThcsshp.Cslss-V.....lstGFFKKI..psspsshlFNGK.HYphVK..KDDDLhKlh-cssslslSslKFNNWKYhYhTEcGVaNVhppsY+ssCPFllGsTLhpsahc+s-..pYLscslhsaMhssscpEhsIaKhYHsAKlsR-l+hlKsNhptshhhs.sCtsCphptppcLN-LFRElWshccs-LllLulYLNp.KhsDllpNl.pC..Ct.t.t.....pCpClp.plc.....lDlpuhKlsLhhcLFhsss.plhcLhWuLla.osphYsphhtshh........sssthlcphsthaapN+p+IlchLapplc+l-alcphh.chssscphlp..plps....................................sscsDshp.cpp....................phlpsFatpYspshplLp+a.NVWWDKLIltRp.sDDLsoWLTRFYhRlhhoK..lslpshsptalpplVpGYLYFRhFTNFNhsNShslhHFsASLuIPoDYEKhClYLsGcPssGKSShFELL-p.lllVHKpDs-pYshsK.+ETsEhEscKh.SQLYVINEhKhCs-oFFKopADSTKSsSssRKYpGppKYEANYKlLIlNNc..PLaIsD.YDKGVpNRFullYhDHpFp.-sh.FsGSVYcHhcsK+YP.E+shh-pLtsPVRlFLuHlLhY+RsP+DGYV.YKslLpsDssapHNLtCLslNNoslpALlYVLpV+...c.us.........thlsEsKlpchIchAssaVcshlH.ph+.....Kpss..........tphLhs-FK+Kap...KaYsscsKhahNLsMAhscpDFNhshPpFKs	......................................................s.Ihpplhpsh....p.c.p.shpshtsssplll+NstTt..p++hhcphp.Fppllsshpsp.stst................................t........t....t.t..h.................................................sHsWshpsNhF.shhV+PFlhp..cpY-t...lp.c..tlshpcFhtSppstasNcsspuGDYhYWPN....huloahGWplaLhhpFsIslsshIPlhHp+pLGsVsLFshsPc......h....FLslEhsl.sssc...ppLFVNG+ohFscp.p........-sLF.lphs....ssssusCKhtscLVhS..sKshFcYI+DsI.NLppClTsscYppllp.lsLppLRhFspps.hsstshsttpph..........phh..IosSSEphc.lpppIspslttIp-tMlcshsppp....tsss.plL......ppYhppSsahNFcaLlhllW+hlp+ppch..papcTDIKLalELLC...........-pl...ass..............ct..shppsht+CcPYhphshplFp+hCsphphFps.s......h.sLuhYauIHahIYhchss............WsaTacsshs...CtlsspVlstGFF+Kl..hsspsshVFNGK.HY..hVK...KDDDLaKl.hppss.shplsslKFNNWKYhYhTcpGVaNlhpspa+ssCPFllGsTLhpshpchs-..pYLPcsshsaMLssucpEhpIh+hYHhAKlCRDl+hl+sNhthh.hhs..sCtpCp.ptp.pLNplFR-lWshscppLlhlulYlNc.KhpDllpNl.+C..Cptt...........pCpClp.plclshhAhKlsLhh-LFssss.pl.pLhW.Lla.ssphYsphhh............sssphlpphsphhhpp+hcIlphLapplc+l-al-.hh.phss.phhlp.lpp....................................................ttpst.t.pps...................phlppFatpYspshplLpKa.NVWWDKLIltRp.sDsLsoWLTRFYMRlhho+..hs..lpsYs..alp..plVpGYLYF+haTNFNhsNShhhhHFsASLuIPoDYEKhslYLsGcPsSGKSSFFELL-p.lllhHKpDs-pa.shs.p.+-Ts-hEssKh.SQLYlINEhKhCs-SFFKspADSoKssSssRKYpG.pKYEANYKhLIlNNc..PLa..lsD.YD+uVpNRFsllYhDHpF..-sh.FsGSlYpHhhsKpYP.E+shh-p.LtpsVRlFLuHlLhY+RsPpsGaV.YKslLpsDshHpHNLhCLslNNoslpALlYlLpl+...csus.........thlsEpKlpchIphAs..alcphL.Hsthp.....Kphs..............tphLhspF+cKac...+hYpt.csphahNLsMuhscpDhshs.hPpF+s....................................	0	0	0	0
+1335	PF04838	Baculo_LEF5		Baculoviridae late expression factor 5 	Finn RD	anon	Pfam-B_5141 (release 7.6)	Family	\N	25.00	25.00	27.80	50.60	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.19	0.71	-4.47	20	57	2009-09-11 05:38:18	2003-04-07 12:59:11	7	1	56	0	0	56	0	153.60	56	58.32	CHANGED	shsLFplFpcFRcscsYpcLIpaLlpNYPsNVKNKTFNFsNTGHLFHSLYAYlPulos..KERKQIRLp.-CIcKLFpNTpNDFKLYsElFchlp...spth.ppCPCpLlppRhpphpsYVcslpsKpFDsKPsKLKKEsIDsILaKYSlNWKslLhKKKh	....hsLFhlFpcFRpppsYppLIcFLlpNYPsNVKNKTFNFsNTGHLFHSLYAYlPulosh.KERKQIRLp.-ClcKLFsNThNDFKLYsEla-hIp...ppth.ppCPCpLlhp+hpphpsYVcslpsKpFDsKPPKLKKEsIDsILaKYSlNWKslLhKKK.....	0	0	0	0
+1336	PF05073	Baculo_p24		Baculovirus P24 capsid protein	Moxon SJ	anon	Pfam-B_6005 (release 7.7)	Family	Baculovirus P24 is associated with nucleocapsids of budded and polyhedra-derived virions [1,2].	21.30	21.30	21.40	38.90	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.32	0.71	-4.72	26	59	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	53	0	0	55	1	180.10	39	86.02	CHANGED	FpYssc.slEVhIIpN.....s-sDpDGYlElsAAA+LLuPhsp.+shsss.LWsNstsSaKLp+NNKNYlHsFuLsKYLSsYshssp..p.spYhsLKpLlsDLlhGsQsp.....shDP.......Ls-IKsQLCslQEslsps..........................................................................tsppsshhuslsuhL-hlKo.lpsDlssKlsFu	...FpYssc.slEVhIIpN.....s-sD+DGYlELoAAu+LLuPhlp...hstusLWsNstsSaKLp+NsKNYlHsFuLsKYLSsYshssp..p.s.pYhsLKpLlsDLLhGsQup.......lhDP..............Ls-IKsQLCslQEsLsps.sths...............................t...........s............p..p.htphlpsc.ts.p.hhs.shsshL-plKs.h................................................	1	0	0	0
+1337	PF04766	Baculo_p26		Nucleopolyhedrovirus p26 protein	Waterfield DI, Finn RD	anon	Pfam-B_6066 (release 7.5)	Family	Family of Baculovirus p26 proteins. 	19.10	19.10	21.80	21.80	16.90	19.00	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.53	0.70	-5.12	25	100	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	55	0	0	98	0	209.60	31	74.22	CHANGED	hsVpY..sVsasp+plslhphcscsVpl+VhsPttps.....tD-s..Lstl.HpFPGVATsllFPpl.ppsstlpVhLss....GsLhcspss..+lahNaHsap+RhVYGQLsulslss...plts+lYlGAPIFpss.+.LVSVVTspa.sDhtcshslhPVTGhRtsuhlSGphphDst...VhVpchcsshSVYGppQLPY..........tlKtaAhst.sst...tshscslhlFas..cc-VpIslscGpFEIs+lRlsGPhlss	......................................h.lp...p.h......t....h.hh............p.t...................h-pl.HpFPGluSs.slhsp.l..pptoslpVh.sc.....h..hchhhs....+hha.saHphsKRalaG.LPshtss-......hh.hLhIGuP....................Iacpc..p..hlSlVTtRa..cs.t...tt.h....haPloGl...GhhSGplsl-ss...lphcpLcsGhuVYG+hQhsY............slKphAhphs...........shhlhhp..pp.l.lsh....s.thph.+hRh.s.hh..........................................	2	0	0	0
+1338	PF05214	Baculo_p33	Baculo_P33; 	Baculovirus P33	Moxon SJ	anon	Pfam-B_6583 (release 7.7)	Family	This family consists of a series of Baculovirus P33 protein homologues of unknown function.	25.00	25.00	63.60	63.60	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.75	0.70	-5.10	18	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	57	3	0	62	0	241.80	45	97.07	CHANGED	Is.TPLhtRYKsSFhLasFRhLDhhRsuPSpcLpplLspElpYLYplsClIsY+-sQps-l-pLhpWshsLss-.hcL-phKhhah-KhppLNL+shpPpcYsaoFoTIWDoIHaLsLlsDDMVtNR..cphsh-hlptpl+phKhlFYNlFhhL.CshCpcHYLTVcuF.haplERIElALaRE+.hGEslhhVD.......E.lstspsscNlLh+athLYsSMlFHNHlNsYR.IQ+Nhcs.s..NapRM-WshYKpLLsl	.................................IP.TPLhs+YKDSFhL...asFRhlDhlR.su.SpcLsplLusElTYLYclACLItYKDlQppElppLhpWuhslstc.hcL-Qh+lhFh-KhpELNLRuhQPKsasYoFoTIWDoIHFLuLllDDMVtsR..cKhsh-hltppL+phKslaYNlFFhLpCshCRcHYhsVKGalIhpIERIEluL...RE+......aGEsIhhVD.......................-..hstsssscNlLMKpthLYsSMlFHNHINsYRaIQ.............RNhcsPs..sap+Mc.........WspYKphLpl.............................	0	0	0	0
+1339	PF02961	BAF		Barrier to autointegration factor	Griffiths-Jones SR	anon	Structural domain	Domain	The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif.  The protein is involved in the prevention of retroviral DNA integration.	25.00	25.00	25.10	33.00	24.40	20.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.86	0.72	-3.68	9	197	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	94	13	127	159	0	83.60	53	87.26	CHANGED	MsoTSQKHRsFVuEPMG-KsVssLuGIG-sLGt+LcspGFDKAYVVLGQFLlL+KD.E-LF+-WLK-oCGANu+QAs-CasCL+EWCssF	..........M.sTSpKHRsFVuEPMG-KsVspLAGIGcsLGp+LpcpGFD...K.............AYlVLGQFLlLKK-.E-lFp-WLK-.sC.GAssKQupDCatCLp-WC-tF...........	0	50	58	88
+1340	PF05112	Baculo_p47	Baculo_P47; 	Baculovirus P47 protein	Moxon SJ	anon	Pfam-B_6441 (release 7.7)	Family	This family consists of several Baculovirus P47 proteins which is one of the primary components of Baculovirus encoded RNA polymerase, which  initiates transcription from late and very late promoters [1].	25.00	25.00	65.80	65.20	19.90	18.40	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.09	0.70	-5.03	21	58	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	57	0	0	59	0	307.50	47	78.87	CHANGED	hFsphhphsSQhLPQCCKYLscsLshYhLa...hp....ths.stshahlccslpVctEGFVphppphVhFclspl.sp...uTPcDL-hYlcsoR..pl.osHctplhcLlh+DRWaKGDFsRL++hLs.pDsssLlsFsCNsLWERGYEsaYTLGQQLSIRITTKLIQSGLDFKH.Qsssss.....ts...............RGWssptFEKhluSIoSlSDlIKRHKhSpKYIlLElssspssphlchLhcppFslIpNsphsNVChIpl.D-DKNShpYLpKLupLIpp+llNVLFVTDlEaYl+pssahFYLYNSLKFYYYCLKNKFVF-hpDYEhlFL	....hFsphhphpoQ.LPQCCKYLs-sLshYhLY....hp....shss.ststhhlscslpVcs-GFVphppshVhFclspl..sp....uTPcDl-pYlchTR..sL.osHDtpllKLlh+.DRWaKGD.hsRL++lLppp-Vs..sL...lpFsCNVlWERGYEsHYTLGQQLSIRITTKLIQSGLDFKHQ.sssss..s.ss................RGWsstsFEKhlsSIoSlSDlIKRH+hupKYIsLElsssphsphlctLhpppFsllpNsphsNlChIpl.D-DKNSh.YLpKLspLlpsKllNlLFVTDVEaYh+pspahFYLYNSLKhYYYCLpNKFVF-tpDYEhlFL...	0	0	0	0
+1341	PF04878	Baculo_p48	Baculo_P48; 	Baculovirus P48 protein	Mifsud W	anon	Pfam-B_6510 (release 7.6)	Family	\N	25.00	25.00	56.10	55.70	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.47	0.70	-5.52	23	56	2009-09-10 15:38:45	2003-04-07 12:59:11	8	1	54	0	0	53	0	376.70	46	98.32	CHANGED	ppaplpYsLRFpK.....tsshppVsFpspLopsEIDSLsFLhucYFDQpphlsl.KGLTFFsEFNKCI-sIKpsFEs+p...-ss.-VKpIFslFL+cEFhsQVPsFphIMpYLppYYKPlssP.slst.l...Cs.pCs.hs+lpCLpCKssYlSsulohhDsulQ-GWDIFLRPMhGlPLhhalLlKT-as..cs-V.FNsDslITNsFsQFFYNLLCDKAsshYhsaKtCpPLlc-C++sshuLpsc-lEhLLshL.Nssohso.......KLasPFKpFM.chshpTKlK..KlNKlAuslFhGFYLRhYLEAtssK.......................shsssELElRNVCRhIh+cYs-cpFEphlpKLpsIKtDLhh.lhpphIVPEphIR+LhsKYsLDpDluhLLppsV	.....s.hplpYsLRFsK.....hcshpsVsFpspLopsEIDSLsFLhS+YFsQpphVsl.+GLTFFsEFNKCl-sIKpsFEs+p....-Ns.....-lKpIFSlFL+.cEFhsQVPpF+pIMpYLppYY+PhssPslstl....Cs.pCs..........hs+...........l..pClpCKssYLSsulSshDsulQcGWDIFLRPMFGlPLhlalLl+T-as..csslFNsDs....LITNsFsQFFYNLLCDKAsstassa..KtCpPLlc-C++sssuLpsp-hEhLLshL.Nssohso.......KLasPFKpFMhchuppTKlK..KlNKlAusVFhGFYLRhYLEutssK....................................shosuELElR.NVCRaIhp.cYs-cphEphlpKLppIKtDLh..lhpphIVsEpaIR+LhsKYpLDp-luhLLppNh....	0	0	0	0
+1342	PF04583	Baculo_p74		Baculoviridae p74 conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4744 (release 7.5)	Family	Baculoviruses are distinct from other virus families in that there are two viral phenotypes: budded virus (BV) and occlusion-derived virus (ODV). BVs disseminate viral infection throughout the tissues of the host and ODVs transmit baculovirus between insect hosts.  GFP tagging experiments implicate p74 as an ODV envelope protein [1,2].	19.40	19.40	19.50	20.40	18.30	19.30	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.58	0.70	-5.18	25	93	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	75	0	0	91	0	236.70	46	37.84	CHANGED	s..psss-s-.LEsIIspFLEDauLlhGIhTslGF-hL.sslcsMLK+INosLIPtLK+hLLsoS+RlTsRLLGETYKAAllHshNRhAIKTlSsVAKAhsRhuhpAuSVlGIlLIhlTIuDLVLhlWDPFGYsNMFPR-a.DDLSpoFLoAYa-Sl.sssoRDlIEFhPca...Fs-lV.....-..pD-.......hhh-ohhall-YluuLEVNSNGQhLphscG-sIsD..FDEtoLVGuAL.ASouhYTph-FhtYTpRHNclLh...ssp	.........................................st...s-pcL-sIIspFLED...aullhGIhsshGF-hLhsshKsMLK+INosLIPhL+phLlssop+VTsRlLGE.TYKAAll+shN+....lAIKTlossAKAhTRluIpAu...SVlGIlLIlhTluDLlLslWDPFGYNNMFPR-FPDDL....SpoFLoA...Ya-Sh.s.psoR-lIEFhPEa.Fs-hl........-..s--...p....hhhpohhalh-YluuLEVNSsGQhLphpcu-sIpD...FDEhoLVGs..AL.ASSuhYT+h-FhpYTtRpNpll...p....................................	1	0	0	0
+1343	PF04513	Baculo_PEP_C		Baculovirus polyhedron envelope protein, PEP, C terminus 	Kerrison ND	anon	DOMO:DM04337;	Family	Polyhedra are large crystalline occlusion bodies containing  nucleopolyhedrovirus virions, and surrounded by an electron-dense  structure called the polyhedron envelope or polyhedron calyx.  The  polyhedron envelope (associated) protein PEP is thought to be an  integral part of the polyhedron envelope. PEP is concentrated at the surface of polyhedra, and is thought to be important for the proper  formation of the periphery of polyhedra.  It is thought that PEP may  stabilise polyhedra and protect them from fusion or aggregation [1].	38.00	38.00	38.00	38.40	37.80	37.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-10.97	0.71	-4.35	23	57	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	54	0	0	54	0	137.80	34	43.32	CHANGED	lsslsQL..slssuNQalELoNhLsAI+hQssplhupLssll-slpspLsslss-lppLlsplss......clsshsssLssAlNpLp...-slRN-LTslNSlLsNLsSSlTNINuTLNNLLpAlsul....shGslsphhsshhss.........lppllsh	...........hsslNQl.....slNsoNpalELoNhLsul+hQNsplhutlsphl-slpspLsslss-lpplls-lss......pLsshsssLssAlNplp...cslRNELsslNSlLsNLsSSlTNINuTLNNLLpAlssl..........shG.slss...thpshlsp.........l.pllp......................	0	0	0	0
+1344	PF04512	Baculo_PEP_N		Baculovirus polyhedron envelope protein, PEP, N terminus	Kerrison ND	anon	DOMO:DM04337;	Family	Polyhedra are large crystalline occlusion bodies containing  nucleopolyhedrovirus virions, and surrounded by an electron-dense  structure called the polyhedron envelope or polyhedron calyx.  The  polyhedron envelope (associated) protein PEP is thought to be an  integral part of the polyhedron envelope. PEP is concentrated at the surface of polyhedra, and is thought to be important for the proper  formation of the periphery of polyhedra.  It is thought that PEP may  stabilise polyhedra and protect them from fusion or aggregation [1].	23.90	23.90	25.30	68.90	20.80	23.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.10	0.72	-4.00	16	82	2009-09-11 22:40:04	2003-04-07 12:59:11	7	2	53	0	0	79	0	113.00	28	41.17	CHANGED	-sssVPlha..ssh.slWVGA-ElLpIL+ls.sstlp....slPpscKphhpcLps............ss-usKhFlTtlGlulLsuRs.s...........................................ctushhsshFlsDshp-hp.......ssp.hC	....psssVslhap.ssh..shWlusDEllplL+hs.tsshp....slPppc++hWpDhps...........sshsusKhFlshhGlulLssRs.s........................................................................phschhhshFls-shhphhtp................................................................................................................	0	0	0	0
+1345	PF04501	Baculo_VP39		Baculovirus major capsid protein VP39	Kerrison ND	anon	DOMO:DM04345;	Family	This family constitutes the 39 kDa major capsid protein of the Baculoviridae [1].	21.60	21.60	22.20	49.60	20.00	21.50	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.01	0.70	-5.42	16	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	0	63	0	287.40	41	92.57	CHANGED	MALVssGssssRhp.NaCIFuuV.pP..FDsCtsYpSPCSsDAosDDGaFICpYHLShcFKMEKMsLPIPDu-ss..tYhRTlG+SLVsHpspuscRILIPTpsNYpoVLNlsuhsluEQLIhHhIYsNpsp.....hscICppL+hsE.pFps-hhplVEplYssTtplLuhTsPstYCopVss.sssRhassss..............ts.....ssu-psasshPsFl+NLIs+sVAPEshpIs....scsLhLRNCsTCtIs.ssGLVAss.......cLYNPVcP+YhhttN-NhLpIcNVLKFcG......NusALQ+.sLuRYEpYPlhVPLhLGpQllsops	.........MALhsss.tspchp.NhCIFtul.ps....FssCtsYsSPCSsDA..sp..c..DGaFICsYHLuphFKhpKhslsIPDu..csN..papholG+SLVspp.s..pu....pRILIP.opsNYpsVLNlsshs.sEpLlaHhIYsNpsp...........................pplCptLphsE.pFpssh.tllcplassTpslLuhssPst.aCupVsp.sssRhassss.................sp.....s.sppsasshPsFLpNLIp+sVAPchhpIs....spsLplRNssTCtIs.ssGLVAss.......pLYNPlpPphh...p.hp.p..NpLpIcsVLcFcG......su.ptLQ+.sLspYEpYsl.lPLhLGpphlsp..s............................	0	0	0	0
+1346	PF04913	Baculo_Y142		Baculovirus Y142 protein	Mifsud W	anon	Pfam-B_6688 (release 7.6)	Family	\N	25.00	25.00	30.60	30.00	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.57	0.70	-6.13	17	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	57	0	0	58	0	445.90	43	96.79	CHANGED	hsL-cc.pLKYLFLuSYFcL.ts.phlss-scsFIt.-YlcsNFp.ls-ssLlpYlsYLpshpLKpll.sDposshFKYlKPQF+FlCsRc.slDIlcFD.s+lYlpPsTslYATNhFVpsPppFphhlY..ptFs+Vas.cRpFVsssppasl.hsGspGalF-cuYlDWsGl+hCpsspl...psspaPYRLYLlGEtMAp+FlcpNI.hs...........pschlLKNFaKGLPL...h+ssaclINSK+FsTcKPNclF-EhppELsspssalKFIQRDYIYDA.sFP-DLL-LL.N-YhTpTSlaKaIpKFh-sp...phts..hsEIVlDRYuVs+YRKh.l+h-ssshaP.shphspsuYIFlpsDhlQI+GTLNAFYlP+ppll.ILAsNsLFGusclL............cFD..p.LlsYppsssPh+lst-hYhlstppKlYLs+ahFus.slPAYLlIRGDYE..oSp.....hKsLc-LpNsWVpNTLLpLhl	................................................................sL-pc.phKYLFlsoYFcL.ps.s...h...lss-spsFIp...pY...lpsNFp.ls-tsLhpYlsYLsphpL+pll.s-p.ssshFKYlKPQF+FlCsRs.slDIlcFD.s+hYI+PsTsVYATNhFVssPpchhhh..lY..scFs+Vhp..p+hFl...s.sssphsl.lsGssGalF-sAYlDWsGV+MCsss+l.....psspaPYRLYLlGEtMApHFlc..sNIhhs..........sssshhLKNFYKGLPL...h+spapllNSKKFsTcKPNcl.F.sElcpELssp....ssalKFIQRDYIYDA.pFPsDLL-lL.N-Y.hTpTSlaKhIsKFhppp.......p.sshhpEIVlDRYuVs+YRKL.IKh-.sshhP.shtts-suYIFlpsDl.lQI+GTLNAFYsPp.plh.ILAsNpLFGuTclL............cF-..p..LlsYppspsPh+lss-sYhVstppKlaLs+ahFus.sVPAYLLIRGDYE..oSc.....hKoLc-LpNsWVpNTLLpLhl.................	0	0	0	0
+1347	PF04684	BAF1_ABF1		BAF1 / ABF1 chromatin reorganising factor	Kerrison ND	anon	DOMO:DM04689;	Family	ABF1 is a sequence-specific DNA binding protein involved in transcription  activation, gene silencing and initiation of DNA replication. ABF1 is known to remodel chromatin, and it is proposed that it mediates its effects on  transcription and gene expression by modifying local chromatin architecture [1]. These functions require a conserved stretch of 20 amino acids in the  C-terminal region of ABF1 (amino acids 639 to 662 S. cerevisiae  (Swiss:P14164)) [1].  The N-terminal two thirds of the protein are  necessary for DNA binding, and the N-terminus (amino acids 9 to 91 in S.  cerevisiae) is thought to contain a novel zinc-finger motif which may  stabilise the protein structure [2].	24.90	24.90	25.20	25.10	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.98	0.70	-5.65	2	57	2009-09-13 16:19:24	2003-04-07 12:59:11	8	6	27	0	35	55	0	198.70	24	64.86	CHANGED	MSLYEYpcPIINKDLAtsDPV.uQpRoFPTLEAWYDVINDYEFQSRCPIILKNSHKsKHFTFACHLKSCPFKILLSaQGs.sSspstDGSPtshsGDttuppptpN........HpNGHTN....utDshuEpE..pDDEDDDAAVTAAIAAAVAAVADSQETIKGPFsVTKIEPYHNHPLESNLSLQRFVLoKIPKILQVDLKFDAILESLCND-DNTVAKFRVAQYVEESGIlDIIKQRYGLT-AEMDKKMLSNIARRVTT.KARFVLKRKK-GVYhhPsuHQloGuDpHQhQhpH......pHQHQ....pQ+phQHpHQpQpQp.QHQpQHQpHVsssppVYQsRItS.SDpD-uulHNLDDsNVRV.AAAAAAAAAALQSR-sHsoE-LKhshtpsQD--ul-sss.sSKRQLHRp-RDRVAEALKMATRDILSNQsVDSDVNVDVDLVTGHKQLSPHDDMAEQLRLLSSHLKEVEAEENVSDsNLKKDDl.DENIQPELRGQ	............................................................................ss....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pt...t...............................................................................................................................	0	3	17	32
+1348	PF02179	BAG		BAG domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain present in Hsp70 regulators.	23.40	23.40	23.40	23.40	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.53	0.72	-3.87	63	795	2009-01-15 18:05:59	2003-04-07 12:59:11	11	16	274	24	498	779	0	77.20	24	25.51	CHANGED	plpplhsclpp.ltsplpph.........tsp...ppcpchhhls.EhLhpt.LlcLDul.p..spGp......slRptRKphl+clQshlcpLD....thp	.......................................................lpplhpclpp.ltspltph....................................ts.p...pppcphhtlp..EhLhp..LlcL.Dul.c......spGpt.......slRptRKphl+clQsllcpLDth.t.................	0	102	206	335
+1349	PF02923	BamHI		Restriction endonuclease BamHI	Griffiths-Jones SR	anon	Structural domain	Domain	\N	22.80	22.80	27.00	27.00	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.01	0.71	-4.30	3	18	2012-10-11 20:44:43	2003-04-07 12:59:11	10	2	15	9	8	16	2	136.40	41	74.24	CHANGED	M+VcNcEILl-sGclssc...IpSIhsEVcsSIcsslWPAsScsFsINsT+Ku.NGVKPIK-pCMpHLc.paGWaLEK+LDIhKs-pKP.GPIDAVK.l....usKtFAlEWETGNISSSHRAINKMlLGMLcGcIIGGILILPSRpMYsYLTDRVGNFcELcPYF-l	........................hcl.pp.hh.pttp..h...pp...htphhs-lhpuIps.haPssspsFhlNs..scKs...NGVhPIKp.ChphLc.phsWhhEp.lcl.hhptp..GPlDshK.h....p.+hhuhEaETGNISSuHRuhNKhlLGlhcG.l.hulllhP.+phh...Y...LTDRluNFcELEPYFp..........................	0	4	6	7
+1350	PF00373	FERM_M	Band_41; 	FERM central domain	Bateman A	anon	Bateman A	Domain	This domain is the central structural domain of the FERM domain.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null --hand HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.53	0.71	-3.95	56	4264	2009-09-17 09:40:39	2003-04-07 12:59:11	13	246	174	84	2246	3702	4	127.30	24	12.59	CHANGED	-.t...hp-shphphhYhQs+psllp...sch...........ssp.-pshhLAuLthQhphG.chs.tpptsts..htt..th...................................................................................................................................................................................ls....................................hhpphppcp.hppclhptap.phps.........h..ottcAch....palphspp......L.stYGsphF	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hp-phs..hhhha.l..Ql.+pcllp.......Gcl...........Cs....css..hhLAu..htl.Q..s..chG...Das...pt.p.tt..s..hh.tpt.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhP.................................................................t...h...p...s..c.........p.......h........cc.c.lh....phap....ph.p.u..............................h.....o.tc.Ach.........paLp.h.sp.p......L.thYGlpha......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	564	750	1407
+1351	PF03114	BAR		BAR domain	Bateman A, McMahon HT	anon	Psi-blast P25343	Domain	BAR domains are dimerisation, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like Pfam:PF00169 and Pfam:PF00787 domains in beta centaurins and sorting nexins respectively.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.52	0.70	-4.85	28	2173	2012-10-03 12:17:00	2003-04-07 12:59:11	13	82	313	19	1287	2310	1	214.10	18	40.80	CHANGED	hpKp....hsRssQhhppKhGtuEpTc..DccFcphEc+hcthpptspclhccsptYlps..shtscph......................hLupshhchucphupcss...u...........sh.phupshcpl.uphhcshptplcpshlcPlpphh.sphpslp+plcKhps+hLDaDsp+p+hp+hp...t.................--EhctAppca-chs-.lpppl.slhstcsphl.splpshlptphcaappshphLpplptpltt	....................................................................................................................................................h..p.h...t...p..h..s.................s...p.t...Tp......-.......t.......p.a.pp.h...p..p..hp..hpp.........spcl.cph....p....t....h...lp...s..........s.h..ptpph.................................................................................hlup.sh..c..h...h..pth..s.......ttpt.......s.................................................................hh....ph.spshc..pl....sp....h........h......p..p.h...p........tp...............l...p...pphl...p.PLp.phh..spht....sl.......p..c...............th+.......K....hpp...+...h.......l.......D.aDt....t+p.+.h..p........p.hpt..tp..t...........................................................-cElc..pA..p.ppa-...phs.......ptl.....p.p.......cl........p........l...h...s..t.c.h.phh.sp.hps.h.h.....p...hp....h...p....aappsh....phhppl.....t........................................	0	333	558	919
+1352	PF01337	Barstar		Barstar (barnase inhibitor)	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	21.00	21.00	21.30	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.93	0.72	-4.14	52	1251	2009-09-10 16:56:04	2003-04-07 12:59:11	13	10	1143	47	253	726	26	85.60	29	72.31	CHANGED	ltlDhsphpscpslhptlupph.sFP.saaGpNhDALaDsLosh............sphshhlhhpthsphpph..cphtt...lhplhc-spcph...ss.t..hp	.......................hhDhsclpspp-hacphupsh..uhs..pth..G....c.NLDuLaDsLts..................hhshPlpI.asphsp.t..p+............c.c..a.ss...Ll.lhc.-.Ap-ch...tt......thh.........................................	0	59	152	209
+1353	PF00967	Barwin		Barwin family	Bateman A	anon	Sarah Teichmann	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.95	0.71	-4.43	8	153	2012-10-01 21:39:58	2003-04-07 12:59:11	12	6	58	2	47	226	1	108.50	60	69.81	CHANGED	SAoNVRATYHlYNPtp.NWDLs..AsSAYCAT..WDAsKPhuWRpKYGWTAFCGPuGPRGQuSCGKCLRVTNTuTGApsTVRIVDQ..CSNG....GLDLD.ssVFpplDT.sGhGYQpGHLsVNYQFVsC	...........................................AsNVRATYHhYsPtp.......sWDLs..ssSAYCuT..WDAs...KPLu.WR.pKYGWTA..F.C.G...P...s..G......PpGpsuCGK...CLp......VT.....N.....T....u...TG..Aps.........TsRIVDQ...C....SNG.......G...LDLD.ssVFpplDT.sGtGhppGHLhVsYpFVsC...............	0	6	28	38
+1354	PF04865	Baseplate_J		Baseplate J-like protein	Mifsud W	anon	Pfam-B_4777 (release 7.6)	Family	The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologues, which are thought to have been horizontally transferred.	20.50	20.50	20.60	20.50	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.59	0.70	-5.03	136	2290	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	1421	0	441	2037	229	212.60	22	56.27	CHANGED	pustL.Dphuth.hs..ltR..hsss.A.ssshh.sss...................................................................................................................usshEsD-s.......hRpRlhhshcshss....uGspssYphaAh...........................ss.ss..............Vscutshss...............u..............................sGs..Vplslls.p...................su......hssspllst.....................Vpshl...........pt-sl..........RPlsc.pVpVtusphhshslssphhhh..sss.spsht.sspps...lpsahtstpph..........Gts...lhhSt.l..hus	..................................................................................t....Lt.hst..hs..h..Rh.ht.u...p.s...h...h.........................................................................................................................................................................t............................................................Gss.....hEo.....Dps.......h.RtRh.t..s..hc.s..hss....uG.s...p..s.sYpha.Ah............................ss..st..........................Vs.cstshss............u...............................................................................................sus.....Vp....l.hllsp..........................su..........hsspsllst..........................................................................Vpphl.........................-sh....................+Pl....s.....s...pl..pV.tu.sthhshplpspl..hhh...sss.p.......sp..sht.....shp...tt........lpta.ht.t...th...........stt...l..stl.....................................................................................................................................................	0	128	281	374
+1355	PF01586	Basic		Myogenic Basic domain	Bashton M, Bateman A	anon	Pfam-B_427 (release 4.1)	Family	This basic domain is found in the MyoD family of muscle specific proteins  that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding [1]. With 12 residues of the basic domain involved in DNA binding [2]. The basic domain forms an extended alpha helix in the structure.	25.00	25.00	27.10	26.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.47	0.72	-3.26	7	456	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	147	4	145	408	0	84.90	40	34.53	CHANGED	MELh.s....hs.......hF...s.pp....FYDupsh.sschp..hhEsht...sp.ssLp.........P-s.ptppE-EHltAPs....cHpsG..pCLhWACKsCKRKosssD	...................................................................................................................................................................F.............ah.-...s...sh..sc.hp...hh-s..s....h.p....s..sL.p.........................s-.t....p...s.s....p...--..E...HVtAPs.............s.pHpsG....pCLhWACKsCK.RKosssD...	0	21	30	72
+1356	PF02028	BCCT		BCCT family transporter	Mian N, Bateman A	anon	IPR000060	Family	\N	20.10	20.10	20.30	20.30	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	485	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.54	0.70	-6.25	145	4820	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	2128	17	801	3301	1081	459.80	34	85.74	CHANGED	VFhhSshllhhhllhsl.....hh.scthpshhsshhsalsspFGWaYllssshhllhslhlAhS+.aGpl+L.GsscscPEaSthoWhuMLFuAGhGlGLlFaulAEPlhHatss................P...ts......psto...pAA.p.AhthoaFHWGlpuWAlY.ulluLulAYata+.+shP................hplposh.hPllG.c..+.hpGs....lGcslDllAlluTlhGlATSLGhGshQlsuGLstlh.G.......l...s.s......shss.plhllsllsslhslSshoGls+..GI+hLSplNlhLAhhLllFlllhGP.ThallsshspslGsYlpsh............hthohhh...ts...hs......sss.................................................WhssWTlFYWAWWIuWuPFVGhFIARISRGRTIREFllGVlllPslhshlWaulFGuoAl.........thph.....puss.slss.............sttss.ssulFshlpph.............Phutlh....uhlsllLlhlFalTSuDSuohVluhloosG...st..sPsthh+lhWulhhuslAhs.LLhs..GG.......LsuLQsssllsALPFsllhllhhhuL.....................h+sLpp-	.............................VFhhoh.h.ll.h.h.h.s.h.h.s.h.....h.h.s.c.....t.stthhss..................h.hsalspshGWhallhsslhlhhsl.hl.s.....hSc.aGpl+.L.G..t.p.pcPEaShhSWhuMLFuAGhGluLlFaGsAEPhhaahs.......................................P......sh.........ps.to.tpAh...p.AhthohFHWGlpuWAlY.ulsuLslAY.Ftap.+s.h.P................h.p...lpusl.hPllG..c....+....h....p.G........l.G.chlDlhullATlhGlAToLGlGs.QlssGLphLa..u.......................l....ss..............shth.phhlIslhshlhs..lSshoGlsK..Gl+hLS.plNhhLAhlLll.hl.l.....l.....h.....G.....P.....T..hal...hs..sh...ssslGs.Ylp.s.h..............hph.oh.t..ts...hs.....pss.................................................................W..h.p.sWTlFYWuW.WluWuPFVGhFlARISRGRTIREalhGslllPshhshlWaulFGs.sAl......................hh..h..............ps..hh....slsp...................................ttss..ptu.la.thhpph...................................P.h..u..p.lh....shlshllhhlFalTouDSuohlluhhosps......................s..cs...s.hhhRlhWulhhu...............lluhs.LLhs......GG...........LpuLQsssllsulPFshlhlhhhhuhhKslpt...................................................................................................	0	247	506	695
+1357	PF02327	BChl_A		Bacteriochlorophyll A protein	Mian N, Bateman A	anon	Pfam-B_38317 (release 5.2)	Domain	Bacteriochlorophyll A protein is involved in the energy transfer system of green photosynthetic bacteria. The protein forms a homotrimer, with each monomer unit containing seven molecules of bacteriochlorophyll A.	25.00	25.00	234.40	234.10	19.20	18.50	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.33	0.70	-5.83	2	70	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	28	4	12	70	0	290.90	78	98.43	CHANGED	TTAHSDYEIILEGGSSSWGpVKGRAKVNVPsA.PLLPsDCNl+IssKPLDstKGhVRFoshIESlVDSsKNpLsVEsDIANETK-RRIsVGEGSloVGDFSHSFSFEGpVVNhaYYRSDAVRRNlPNPIYMQGRQFHDIlMKVPLDNNDllDTWEGh.pulpusGu.FsDWIREFWFIGPAFsAlNEGGQRIS.I.VNS.sspuGEKGPVGVoRW+FSHuGSGlVDSISRWsELFPs-pLNKPASlEuGFRSDSQGIEVKVDGphPGVShDAGGGLRRILNHPLIPLVHHGMVGKFNDFTVDTQLKIVLPKGYKlRYAAPQFRSQNLEEYRWSGGAYARWVEHVCKGGTGQFEVLYA	.........TTAHSDYEIlLEGGSSSWGpVKuRAKV.NVPsA.PLLPADCNlKIssKPLDstKGhVRFousIESIVDSTKNKLsVEsDIANETK-RRIuVGEGpVoVGDFSHoFSFEGSVVNMYYYRSDAVRRNVPN..PIYMQGRQFHDIlMKVPLDNNDLIDTWEGh.pulpusGA.FsDWIREFWFIGPAFTAlNEGGQRIS.IpVNu.hssESG..-KGPVGVSRW+FSHuGSGlVDSISRWAELFPsDpLN+.P.......ASlEuGFRSDSQGIEVKVDGshPGVShDAGGGLRRILNHPLIPLV..................................................................................	0	2	3	9
+1358	PF00452	Bcl-2		Apoptosis regulator proteins, Bcl-2 family	Finn RD	anon	Prosite	Family	\N	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.42	0.72	-3.89	72	878	2012-10-03 11:38:54	2003-04-07 12:59:11	14	11	175	146	362	880	0	97.20	28	43.78	CHANGED	Lpplu-clppphpph..apshhpplpl.s.tp..shph....FppVupclFps...........slNWGRlVulhsFuutlsh................chhpptt...sth...lpplsphhspal.ppphssWIpppG.GW	..................................................LpphG--hppp.hpp...apshhppLp....h.......sstp......shpt.......FtpVsp..-....lFpc.................................slNWGR.lVuha..sFuutlsh..................cshppph......tsh.................lp.plspahs.p.al.pcplt.s.W..ItppG.GW..............................	0	81	111	190
+1359	PF04538	BEX		Brain expressed X-linked like family 	Finn RD	anon	Pfam-B_3086 (release 7.5)	Family	This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals [2]. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in Pfam:PF07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way [2].	26.10	26.10	30.10	31.20	23.40	25.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.38	0.72	-3.79	20	315	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	27	0	152	306	0	126.00	29	85.30	CHANGED	M-.......KsppENEtcsp.sps+sE-t.............................................................................ppPhtss-tpcscGshRc.+ltcsh.pF+tDI.sRplss-Ehhct.sD-hpRhhEEhRclRpKht...............shHacp+cspsh.	..........................................................................Mp.psppENEsc.p..stspsEct..............................................................................................pcPhtss.spcsc...ssh+c.thtpsh.pa+.EDl.sRplssE-MhRt.s--hpRh.EEhRcl+pKht...............shHapp+cphsh.......................	0	14	14	19
+1360	PF04714	BCL_N		BCL7, N-terminal conserver region	Mifsud W	anon	Pfam-B_5900 (release 7.5)	Family	Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome [1].	25.00	25.00	29.00	28.30	19.50	17.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.48	0.72	-4.39	2	196	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	90	0	108	180	0	45.70	73	23.78	CHANGED	hsRShRAETRsRuKD-l++Vhpul-KVR+WEKKhVhIpDTsh+IYKWVPluu	........Ro..lRAETRSRAKDDIK+VMsslEKV..R+W.EKKWVTVG..DTSLRIaKWVPVo.p......	0	23	32	61
+1361	PF01869	BcrAD_BadFG		BadF/BadG/BcrA/BcrD ATPase family	Enright A, Ouzounis C, Bateman A	anon	Enright A & Pfam-B_5854 (Release 7.5)	Family	This family includes the BadF Swiss:O07462 and BadG Swiss:O07463 proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase Swiss:P11568. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerise. This family appears to be related to Pfam:PF00370.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.60	0.70	-5.10	19	4290	2012-10-02 23:34:14	2003-04-07 12:59:11	15	24	2197	20	1108	3723	293	259.00	21	58.92	CHANGED	lGlDuGuTso+sllhs........cpup.lhspshssu..................................................................sshptss.p.s.t.h.culppshcpuGhshp-...............................................................................................lthh..sssGhGhsshs..hstchhht...........chsspscGshhhhsssp....uVlsIuGpsopslthc.sGpstsashtuhshuspGphhtlsuctlshslcphsulstpus............................ps.tthsutssshutp.hhsthuus.tutcIlsshspslutplhshhpphushtt.......lhhsGGlups.shh.tl...l.pphhph..h.h.s.sthsuAlGAuLhA	........................................................................................................................................................................lGlDsGSTss+s..l...l..h.s...........p.s...t...p...l...l......h...p.h..h...t...h.s..................................................................s.sh.......................................h.......p...sl.p.p.h.h...p...p...h....t....h..t.....t...............................................................................................................................................................h..t..h..h............s..s..s.G....h....G......t.t.t...h...t..............ht...ph.hh...................................Elhsp..sc...u..s.t...t.....hh......s..sss......................sll.-..IG.G..pDu...K.sl..t..l.........c..........s.......G......t.....h...........t......p.............h......t.h..............ss..............tCu.u.u.s.Gu..a..lc.h..h..u..p.t.....L.p..h...s.l..p.....p..h......s....p..hu..psp.........................................................................................................................ps...hsl..s..u..c....C...s.V...F...A...p....o.p..l...p...s...h.....p.t.ss......s.t.pcI.h...suls.p...u.lsp....p....s....h..s..h...l...t....p...h...p.......t.........................l.shtG...G.....s.....h..t..s.............h.....h....p.t.....h.............p....t..h.......t..............h..........s...t..h.......sshGAsh........................................................................................................................................................................................................................................................................................................................................................................................	0	477	821	983
+1362	PF03170	BcsB		Bacterial cellulose synthase subunit	Mifsud W	anon	Pfam-B_3954 (release 6.5)	Family	This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells.  While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalysed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognised sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase (Swiss:Q59167), which corresponds to BcsB.	20.10	20.10	20.40	20.20	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	605	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.74	0.70	-6.50	55	1096	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	931	0	189	915	40	545.50	33	75.33	CHANGED	sss...sspspshsFtplGh..sslsLpGspsptslsFslpsD.clVosApLpLsao..SPuLlsshSp....lpVhlNsplluslslsppps...phsshplslsPt.hhs..saNplplchhu+asts.CpssssssLWssluss.SpLsLshpslsl..tscLuhLPsPFFD..............tpstptlslPhVhsssss.splcAAuhlASahGshAs.aRstsFPshhs.......slPsps.....ulVhuossphsshl....shPs..h...sGP.......slthlssPssshs+lLlVhGRssp-LppAupuLshus..sshsGssstlsp......sRpPYDAPsal.o-RslphuELst....spsLpssGhtssslplshpl......PPDLahhpspslslsLcYRYoss...stssSpLslslNsphlpohsLss.t........h...hhspsshssppplplP...shhlsupN.......pLphcFshss.psu....tCpsstss..s..+usIss-SoIDhSsh.HahthPsLssFAsuG.aPFoRhADLS..cTslllPsp.....PsssslsshLslhGphGttTGhPshslplsss.....ss.ssh.pcc.DlLllGshss..shhhph.........sspl.shhhssspth.ht.s.....h.tth.h...t...ssttssssthsls...usushuslhGhpSPhsspRo........lVulh	.................................................................................................................................sts....ssppsploFsplu..ssshsLpG..hss.s.u.slpFshcuD..clVopAhLsLpYo.sSPuLl.ssp.Sp.........LpVh.lNsph..hus...l..s...lsccph.....p..........pshtphsIssh.hls..caNpl...pl..c...hl...u....+apc.....s...C.Esssos.............sLW.lclsps.SsLsLsapt.lsl...ps-LucFPsPFaD..............s.c.c.s.p..s...slsh.V.hs...s....s..Psss.......pAuu.llAS..WFGutus...aRuppFPVh.hs....................pLPsps............................ul..Vhuos-c..hPshLp.........stPs.....l......puP...............................slph...lsp..Pp.........s........s...h.sK.L.LVVh.G+s..-c-LhpAu+ulApus.........hhhpGpsssVsc..p.h.sRpPYDAP.sWlpoDRs.l.......shu...ELtp..........ppLp.ssGht.......ssslslslsL...PPDLahhcussls..hclpYRYo.s..........sp-sSphslslNsphlpohsLss.t...............hhpshh.ssctslsIP...slpluupN............pLchcFphh....s.....hsu..........sChshtss...ts.+ssIs.s-SoIDhSp.hhHah.hPcLt..hFuNuG.FPFoRh.ADL.S...pTh...sVhPcp.....PspsphpsLLshhGhlGs..tTGhsshsls.lscs.....ust....ts..cct.DlhllGshss....hhp...........................scpl..shhhpss.psh...htps............h...............tttttspst.thp....sssshsslhuhpSPhpstRsllsl..........................................................................................................................................................................	0	37	85	137
+1363	PF02138	Beach		Beige/BEACH domain	Mian N, Bateman A	anon	IPR000409	Family	\N	21.00	21.00	21.20	21.80	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.94	0.70	-4.95	145	1432	2009-01-15 18:05:59	2003-04-07 12:59:11	13	80	283	6	960	1325	26	252.20	44	12.87	CHANGED	T..pcWtptclSNF-YLhhLNhhuGRSaNDloQYPlFPWllsDYpSp..pl....Dl...s..sspsaRDLoK.PhG....uh.spcRhppht.pphpp.htp.t.....................................a.hYuoaYS..sshsVhhaLlR..l-PF.oshtlplQuGcFDhssRlF....pSlppsaps.s...ps.sDh.+EL...IPEFF.......hhPEhLhN.NphshG.h.....psp.lsDVhL...PsW..u..ps.st.....cFlhhpRcALEScaVSppLppWIDLIF....Gh+Q+GptAh.ps.NlFp.hsYpstht......thps...ppp...thpshlpshGQ....sPt.QLF.ppsHPpR	.....................................................................pcW.p.tc..ISNF-YLhhLNslA..GRoaNDL.sQYPVF...PWllsD...Y..sSc.....pL..................DL.s.......sPpsa...RDLSK..PhGs...s.cR.hptht.c+Ycp..hcp....................................................................s.a.HYGoHYS.ou.t.hVhhaLlR.h...pPF.ophhl...pLQu.....G.p.FD...h...s...DRhF..................pSlt.psWps....s.......pshsDV..+EL......IPEFa......................a.h.P....E.hL.hNtst.hs.hGhh......................pssphlsDV.LPsW......A.......ps....Pc.................cFlt.hpR.pAL.......ES-aVSpp.....LHp.....WIDLIF....GY.KQ......p.G...tAl....cAhN.VFa.hoYpGsssh...............................ptlpD...h.+puh.s.IpsFGQ.sPp.QLh.ppPHP.R..........................................................................................	1	439	568	771
+1364	PF00407	Bet_v_1	Bet_v_I; 	Pathogenesis-related protein Bet v I family	Finn RD, Radauer C	anon	Prosite	Domain	This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants [1]. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10 [2]: - Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1 (Swiss:Q8H1L1), an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones [3]. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine [4]. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber [5]. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens (Swiss:Q9AXI3).	20.80	20.80	20.80	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.78	0.71	-4.60	34	1250	2012-10-02 19:24:03	2003-04-07 12:59:11	14	8	180	62	290	1394	4	142.70	32	95.24	CHANGED	uhsGph.sElplpssAc+aa+hapt.cschlPcshsc.tIpulclhEG-hsss..GoI+pWsash.-Gc.cshKE+lEhsD-p.pslsapslEGclhpcaKpatsshphh.PKspGs.slsKhohcYEKhs-css.Ppchlch....stplsc-l-saLlus	...............................................shptEhss.s.lsss+la+u.hhh.-s....ssllPKl.hPp.slpolEh.l.E....Gs..G.GsG...........TI..Kcls.F.....s.............c....u..........s...h.pa.s..Kc+.l-tlDcs....NhthsYoll..E...G.s..s.l.s..c.t...lc.p.l.s.hc..hKl...s...sss......G...G...S.lhKhosc..Yc...s...ps..stt...............pc..hch........stslh+slEsYLlt...........................................	0	47	183	242
+1365	PF03494	Beta-APP		Beta-amyloid peptide (beta-APP)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	40.80	39.70	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-7.73	0.72	-4.48	2	171	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	48	133	33	165	0	38.90	89	6.25	CHANGED	.tc-pt.EVaHQKLVFFAEDVuSNKGAIIGLMVGGVVIA	...FRHDSGYEVHHQKL..........VFFAEDVGSNKGAIIGLMVGGVVIA.	0	1	4	11
+1366	PF00144	Beta-lactamase	beta-lactamase; 	Beta-lactamase	Sonnhammer ELL, Bateman A	anon	Prosite and Pfam-B_106 (Release 7.5)	Domain	This family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.82	0.70	-5.42	127	13942	2012-10-02 21:13:33	2003-04-07 12:59:11	19	160	3791	302	3910	15232	5643	321.50	17	75.55	CHANGED	lpphhpphht.............................hsGhs............lslhpsGchhh.th...............u....................shss......cohFtluSsoKshsussl.hthscpG................t.........lsL-csl.......................pcals....................t.stptlTlpcLhsaouGh........h.tt........................phhthhtth...h............sGpth..Ysssuhs.Llutlltpss..G.ps.....htphlpcplhps.................h..shpcsthssststptphstsh..t..............................................................shhusspDlt+ah.....................h....tthhsttthpph..........hshhtsststssthttsh....uhGahlsstst............................hhtpsG..........shushhhhsspp..........slslsh...lsNptt..ttttttsthhhthst	.........................................................................h.........................hsG.h.s................l.h.l...h..p....s...s..p..h.....h.h.p.ph.h...................................................Gh...................ts.h..t.t.t.............s.h.ss.................s.o..h..apl.u...SloK..s.h....s..u..s.hl..h......p....L.h..pc.G..............................p..............l.s..L..c..c...s..l...................................................................................................sca.lP.......................................t....t....s...t..p....t....lT.l...pp.....LL...s.H..o.....o..G.....l..s.........................t...t.h.h.ptt.................................................................tp.hhp..h...h..t..p...h.......h..t..ht................................................PG..s...p..ht...Y.u...s.........s..shh..lLuh.....l...........l..c.pso...........G..ps....................................hp..p.h...h..p...c..p..l.....hpP.............................................L.....u..h...p....p.....o........t.....h.......t.....s......s.....t.....s....t.............t....t......h.....s...h......s...h.............................................................................................................................................................................................ssuulh.oos.pDh.....t+ah.................................................h...t.t.t..h....t.t..p..h..h.p..th........................................h...h...h...t....h....h..........s....s...t........t..t..s.h.........................uh..G.a..h.ht.t.tt............................................................................................thh...t.+s..G..........thus.....h..h...h...h.....Ppp....................................ph.sls...h....h.s.Nt...................thh........................................................................................................................................................................................................	1	1339	2525	3318
+1367	PF01212	Beta_elim_lyase		Beta-eliminating lyase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.74	0.70	-5.27	53	4088	2012-10-02 18:26:03	2003-04-07 12:59:11	16	26	2725	70	1143	27402	8234	301.90	26	73.88	CHANGED	DLtSDoht.s.TsuMpcsh.stA..hGD.-.s.YusD........sstcLccpss...........-..............................lhGh-.ss..l..F..............ss.o.GTtANplul....hshs.p....pphlstcs.....uHhahcEs.uuhs.l..uGspshsl...ssp...s.............Gshslsclcp.tlct..s.........a.spssllslpsTps...Gpllsh.cplcplttls+cpG.......l.lHhDGARhhs..Au............sslsssl+Ehs..uh.sDulshshoKshssslG.ullshscc...........................................................alppthch..p+....hLGuth....R..psG....llsA......................................uGlhul-ps......hhphtcDpcp..AcpLup...tlpt........lsh......s.hsp..hs....spsphshltts	............................................................................................................................................................phhoDs.....ss.t.h...h.puh....h...t.....s......hG..D......-....s....Y....G....s....D..............s..s..t....p....L..p....c....t....h.t................c.............................................................................................l...h...G....h....c......su.......l....F........................................hs....s...G...T......t......A...N........l...s.l.......................s..h....h....c..........p....t...p....p.....h...l...s.sps............................u.H.h..h......h.....p......E..s......Gu..h....t..h........s........G......h....p....s...h....s....l.s.....s..pp.....................................................G..p...l...s...h...c..p...l.c...t...tlct.s.....................H.h.s.p..s..t.h.l.s...l...p..p..T.ps.........G..p..l.......h.....s.....h......p......p......l...c..p....l......t.p..h..s...+.....c...p...s...............ls...l..a........hD...........G.....A......R....l..h..p.......A.s..............................................ss..h..s...h....t..h...p...-...h.s..........p.h....s..D......s....h...s...........h........s...h...o....K....s...h...s....s...s....h..G....u......l.l.s...h.s.cc.......................................................................................................................................................h.l.t..p...t....h..p...h......t+.............h.h....u....u....t....h...........+.........p...t.....G........llsu........................................................................................................u..u..h...h....u..l...c.s.........h..h..h..t...c....s...p..p..p....A.p.p.l..sp....t..l.pt........h..s.h.....h..h...p.....s.....opthhs.....h...................................................................................................................................................................................................................................................	0	371	694	965
+1369	PF02929	Bgal_small_N		Beta galactosidase small chain	Bateman A	anon	Pfam-B_592 (Release 6.3)	Domain	This domain comprises the small chain of dimeric beta-galactosidases EC:3.2.1.23.  This domain is also found in single chain beta-galactosidase.	19.80	19.80	19.90	20.00	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.69	0.70	-5.38	21	2500	2012-10-02 23:57:29	2003-04-07 12:59:11	12	42	1440	273	453	2175	266	257.00	27	27.63	CHANGED	slp.utshphhFs+psGtlpshh.hpGpchLhp..sspssFaRAPTDNDhGss.s.ch......tp............WpsAGh.phppcl..h.s.ptt..............s-shlplphsathsshh...htsphsYplpssGplplslshpssts....lP..lPRlGlphtlsps.hsslpaaGhGPtEsYsDRppuuphGpapsslsp.hssYlhPQEsG.+s-s+hlslpttt.........stlhlsup.....FsFus...YotppLpp.ssHhp-L.tpctshLplDttphGVGG.DSWussVpspYpLts.psapasaslp	.......................................................................................................h.lpstshph.Fs+.t.s.G.hlspht...h........ss....p.......p.....h..lh..p........s..p........sF.aRA.s..hD.....ND....hs.....t.tsh...........................t........................W.p.s..s.s.ht.t..h.p.t...ph..t.h.ts.pp..s......................................................sts.....lh..s..p..h...s.h.....h..........h.s....s.....h..h...hpsphpYp...l....s..s.........s...G...p.....l...pl..s..h..p..h..p..h.ts.s...............hP....p...lP+lGhph....tl.....s......tp....h....sp...lpaaGhGPtENYsD+ppuuhhuhap...s.s...ls....p..h..a...p.....sY..lhPQEsGt+pssRahsl.tstt......................................sul.hlpup...............t.h.p.Fus............Y.......ot........p....p....L................p.................p......s........p......Hp...p..-L..p........t.....p..c..t...s..hL.slDttph.GlGu.sSWG..s..p..l..h..s..p..a..pl.h...pp..apaphhh.h.........................................................	0	131	310	401
+1370	PF02180	BH4		Bcl-2 homology region 4	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.50	20.50	20.50	20.90	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.60	0.72	-6.77	0.72	-4.42	11	223	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	58	92	80	246	0	25.40	54	12.65	CHANGED	huhssRpLVhcFlsYKLuQ+Gashtpt	.....u.sNRELVhcalsYKLSQ+GYsWst.h.....	0	5	12	29
+1371	PF02368	Big_2		Bacterial Ig-like domain (group 2)	Bateman A	anon	Bateman A	Family	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial and phage surface proteins such as intimins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.64	0.72	-4.09	46	5992	2012-10-03 16:25:20	2003-04-07 12:59:11	13	651	1569	19	1313	5130	392	78.80	23	17.92	CHANGED	sssplslsss......ssuhh.utshphsssth.ssuss......tphoWpS.sNsplAoVs..........ssGhV...ouhs..pGsssIsssssc..spssshTl	............................................................................tlpls.s.........phsl..h..h.G.....t.s.....h.p.l.s..s..s..h.....t...sssuss.............ppl.s....W....s....S.....u.....s.....s.s.l.A...oVs...............tsG.tV...........s.uls.....tG...s.....s.s..Is..s...s.s.ss...s..sh..........................................	0	641	1057	1180
+1372	PF04775	Bile_Hydr_Trans		Acyl-CoA thioester hydrolase/BAAT N-terminal region	Kerrison ND	anon	Pfam-B_2191 (release 7.6)	Family	This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT) [1].  This region is not thought to contain the active site of either enzyme.  Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism [2].  For example, in peroxisomes, the hydrolase acts on bile-CoA esters [1].	21.30	21.30	22.50	22.40	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.52	0.71	-4.42	37	429	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	155	4	254	436	2	126.40	34	30.24	CHANGED	hD-.lpItlsGLsPsp.VTlpuphp..c...........-.....pGthapShAtapAsppGpVDLscsssl.uGoYpGl-sMGLhWShcP...p+hshthhppsl......h.pshhlplpshssp............lupsphcRhahusGVpRh.VcEs	.......hDEslpItlpGLsPtp..VTlcuphp..c................-..pG.s.hapupAtYpADppG.plD..Ls+ssul...GGoYsGl-PMGLhWohcP........p+sh.h...+..hh+psV..........sPh.hVplplhsup................thlupsshcRha.huPGVpRhsV+-..................................	0	37	72	171
+1373	PF03496	ADPrib_exo_Tox	Binary_toxA;	ADP-ribosyltransferase exoenzyme	Griffiths-Jones SR	anon	PRINTS	Family	This is a family of bacterial and viral bi-glutamic acid ADP-ribosyltransferases, where, in Swiss:Q93Q17, E403 is the catalytic residue and E401 contributes to the transfer of ADP-ribose to the target protein. In clostridial species it is actin that is being ADP-ribosylated; this result is lethal and dermonecrotic in infected mammals.	23.40	21.90	23.50	22.10	23.30	21.80	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.33	0.71	-5.09	26	558	2012-10-01 23:25:29	2003-04-07 12:59:11	9	24	360	74	64	557	16	184.60	17	40.09	CHANGED	AcpWGpcthcpatpp........................ossE+pAlptYTptsYpcINshL..Rpspsph.th...splpcp...........lcpl-uAhpKs.slPcsIhVYRtss.t.ht...t......................ppthpthpshhhu+hhp-tuYhSTSLsps.........uuFutp...l.h+lplsKGopuuYlss..l...............................Ssa.ssEhElLls+uspacl..........schsh.......sssppclll-Ahhltp	...............................................................................................................................................................sttch.tu....lt....Y.s........s......t..s..............h........t...tlN......phL......Rt..sp...............th......ppl.pp........................l...p.p.l...ssuhp..+....h.....h....p......s..h....h.l....Y.Ru........................................................p.thp.hh.p.th.h.....G.p.hhp.p.pu.ahS..TS..hstt......................................ts..hstp..........hh.h...clp.l.s.p.G.p...p.......u....h.h.lss........l............................................................o...th..ssEtElLls+ssph+l...............ppht.........................ht..............................................................	0	25	39	48
+1374	PF03495	Binary_toxB		Clostridial binary toxin B/anthrax toxin PA	Griffiths-Jones SR	anon	PRINTS	Family	The N-terminal region of this family contains a  calcium-binding motif that may be an EF-hand.	19.70	19.70	19.80	19.90	17.80	19.60	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.50	0.70	-5.85	8	100	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	61	59	4	126	0	353.70	41	51.40	CHANGED	s.sDTDsDuIPDsWEhNGYTl..pNKlAV..tWDDshAp.pGYpKYhSsPhcupTsGDPYoDaEKsuGcIDpuluhEARcPLVAAaPsVsVsMEKlILSKNEclSsppst........olSsuTSoSpTasNT.GAslsAuhuhhs.....hShuVSANYSHo.psTVus-aosSp........oaupohulNTA-uAYLNANVRYhNsGTAPIYcVpPTTohVL.csp...TlATIKAK-NphApsIsPsppYPpKupsuIALNTMDDFNS+PIslNYsQLcp.LpssKslpL-TsQssGsYuphs.osGplhlss..sWusllspIpupTASIIlssustss.E+RVAA+-.sNPEDKT.PcLTLKEALKlAa..uhpE.csGlLaY...Ns......KsIsEs.slphhlD-pTuppl+cQLpshss.....KslY....clKLpsKMNIhI+ssohhhs	..................DpDsDuIPDshEhNGYTl......psphAh.....tW-sphtc.pG.......hpKYlSsPhcusTsuDPYTDaEK.soG.phDpsss.pshsPlVAAaP.ltVshE+lllSpscshosppst........olS+s..oosS..po..p..os......ssGssspssh..p.h.s........huhuVSssaSpo.ppTss.pcS.up........sWupshslNoucuAhlNsNlRYhNsGTAshYpVpPTTslVL....ssp...oluTIKA..ppsp.h.up.LuPsptYPp+shsslulsohDpFuSp.IslNhsQLcp.l-ps.c.lpL-TsQspG.hshhs.psG.plhsts..pWuthhspIpthoAplhhsht.s.sh..chRlsAhs.psP.-pT.PphTlt-Alphua..thpc..ss.h.a...ps......h.I.c.....h.hDppTspphcppLtphts.....pplh....phhlp.tMNhhl+..............................................................................................................	2	1	2	2
+1375	PF02084	Bindin		Bindin	Mian N, Bateman A	anon	IPR000775	Family	\N	21.70	21.70	24.20	21.70	20.30	21.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.88	0.70	-4.31	10	599	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	43	0	2	613	0	138.30	52	94.71	CHANGED	YGNt...NYPQhhsPphGGsNYs.......GQ.sQQGYuspGM........GGPVGGG...s.uss.sssGt.uGslsGGG....huP.....h.spu.tss.uphc-YSSsshp-s...........-TTISAcVM-cIKAVLGATKIDLPVDINDPYDLGLLLRHLRHHSNLLANIGDPEVREQVLSAMQEEEEEEEpDAANGVR-NVLNNlN..NuPGsGGaGGstu...............uGtsGGh...sshG..sQGtGGshth.Ghssp...usuYN...QGYRQG	...............................s.......thsQ.hs..MGGuNY..............GQ.sQQ.....GYussGM...............uGPVGGG.......AMA.t.Ph...........G.G.GGAMAt...P..VGGGu............................uGPst..........h.G.....t.h....................ts.p-YSSs.....t...........tthIss.......................................................................................................................................................................................................................................	0	2	2	2
+1376	PF00351	Biopterin_H	biopterin_H; 	Biopterin-dependent aromatic amino acid hydroxylase	Finn RD	anon	Prosite	Domain	This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.	22.00	22.00	24.60	24.60	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.06	0.70	-5.68	6	1616	2009-01-15 18:05:59	2003-04-07 12:59:11	16	13	829	37	525	1403	197	213.20	33	70.19	CHANGED	PWFPR+IsELD+CsphlhpYss-LDhDHPGFsDpVYRpRRK.hA-IAasYKHGDPIP+VEYTcEEhcTWtpVFpTLpsLYPTHAC+EYhcsFsLLp+aCGa+EDNIPQLEDVSpFL+-pTGFpLRPVAGLLSuRDFLAuLAFRVFpCTQYIRHuSsPMaTPEPDsCHELLGHVPLLAD.oFAQFSQEIGLASLGAoDEtIEKLuTlYWFTVEFGLCKQsGplKAYGAGLLSSYGELhHuLS-+Pcl+sF-P-sTAVQsYpsppaQPlYaVuESFpDAK-KhRpaAuoIpRPFuV+YsPYTpuIEVLDSsppIpphh-slpsElphLssALsK	................................................................................................................................pYo.t-.tsWt..lhp.p.................thh.thAs.ttahpsh..l.....h..cplPplt.-lsphLt..............tto...G..a.plhs..ls.uhls.ttFht..hLA...+.hF......sspal.Rp.pp...Yh.E.....P..DhhH-lh....GHsPhl.....h..s.....s.........a..A...p.....a.p........t...h..G............hu.....h.t.s.........s...........t................t...h.t...........h...........L.u...p.......h.......aWa..TVEFGL.h.........p....p............t.......t.........h+hY..GuGlLSS..uE.....................a.s...h.......o.......s..t........s..ph.h.s.ap...sh.h.p.a.hs.hQ.hYal.ps....h....t...............................................................................................................................................	0	167	254	398
+1377	PF00364	Biotin_lipoyl	biotin_req_enzy; biotin_lipoyl; 	Biotin-requiring enzyme	Finn RD	anon	Prosite	Domain	This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.22	0.72	-4.34	49	25099	2012-10-02 20:27:15	2003-04-07 12:59:11	17	167	4936	74	7239	20327	9244	71.80	30	15.82	CHANGED	tplpsP.hGphhp......thhVcsG-pVptspslshlEu.Khph-lsust.sGslpplhsptGss.VpsGphlhpl	....................................h..ltsP.l..Gps..h.p.........s....l....hphhVpsGDpV.........pt.sps.L......h.hl...E.u.......................K.....h.....p...h.....-......l.......A..s...........t.....s...G...........s.........l.p...c...l.h.....l..p.....p..G.ss..Vp.sGphlhh..............................	0	2248	4430	6064
+1378	PF03744	BioW		6-carboxyhexanoate--CoA ligase	Bateman A	anon	COG1424	Family	This family contains the enzyme 6-carboxyhexanoate--CoA ligase EC:6.2.1.14. This enzyme is involved in the first step of biotin synthesis, where it converts pimelate into pimeloyl-CoA [1]. The enzyme requires magnesium as a cofactor and forms a homodimer [1].	25.00	25.00	30.50	30.40	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.48	0.70	-4.94	17	405	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	395	0	39	195	3	228.90	45	69.10	CHANGED	aSl+MRAS......psspHISGAEcls.stpclcphlsphlp+uhsHpp...G.psDFlslplEclp.csIphlp.sLslcohpstshEcu+phApplLppt............GlscphhcpAh.chlscs......shRGAhllshcoGpRL-s.ctpRGVRVophDhs-pp....p.tlhpps...spRsh-AlAlAoKVhst.GVlAELChSDDssYTTGYVAscphGYhRIsslKptGs..GGRlFFlcsshcl.p..shIphLEppP..VlIp	......YSl+MRuS......................spshHISGAEols...p.hccIEQTVpphhp+uhhHpp...G.psDFlsl.+lpclh.psIppI..AL.l...................hc-s+t.hpcLh....p.c.s............GVo.cpAlppuh.phlpst.....sshpGAllLsAhoG+RLD....u..spRGlRsT+Fu..hpshss...........ps....hs...cRhp-ALslASplsAtPhVhuELClSDD.sYTTGYhAssclGYpRlhslKssso.hGGRlIFVD.s.s.h.....sl..s...phIoaLEspP......t.....	0	13	23	34
+1379	PF02632	BioY		BioY family	Mian N, Bateman A	anon	COG1268	Family	A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin [1]. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes [3].	23.10	23.10	23.10	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.91	0.71	-4.56	153	2666	2012-10-03 02:46:00	2003-04-07 12:59:11	9	7	2228	0	579	1839	1577	149.40	30	79.42	CHANGED	l.Ph....ss..VPlThQshuVhLuGslLGs+hGsluhllYLllGslGLPVFuGG..p.G.G.luhhhGPTuGYLlGahhuAhlhGhls.......c+hthp.................hhhhhhshlsGhlll.YshGhhaL..s.....hht..........t...lshsp....Alh.....huh.hsFlsGDllKsslAshlsht....l.pchh	.........................sh.ss..VP..lTLQshulh..LsGhlLGs+hGslohhlYlllG.sl.....G.L...PVFuGG.......p...u...G.l.....usl.h..G.P.TuGYLlualls.Ahl.sGhlt.....cphtpt......................................h.hhhh.h.s.h.l.hG.hhll.al.h.Ghhhl..t...........hht....................s......hshtp......Alhhuh.hsF.l.ssDl.l.K.slluuhluhtlh..h.......................................	0	205	400	503
+1380	PF00653	BIR		Inhibitor of Apoptosis domain	Bateman A	anon	Prosite	Domain	BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin (Swiss:O15392) [2].	22.90	22.90	23.00	22.90	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.81	0.72	-3.55	184	1889	2012-10-01 20:49:39	2003-04-07 12:59:11	16	35	348	189	901	1890	5	67.90	37	17.22	CHANGED	RlpoF.p.t.......................WP...hth...psp...p.LAcAGFaYsGt................sDpVpCahCphtl....psW.p.sD......sPhpcHt+atP....p.Ct...alp	...............................RlpTF.p..........................WP.......h..........s.s.s.cpLAcAGFaYsGt...................sDpVpCFhCsstL....p.sW.c.sD.......................cPhp-Ht.+ahP.....p..CtFl..........................	0	236	332	623
+1381	PF04197	Birna_RdRp		Birnavirus RNA dependent RNA polymerase (VP1)	Bateman A	anon	Pfam-B_2204 (release 7.3)	Family	Birnaviruses are dsRNA viruses. This family corresponds to the RNA dependent RNA polymerase. This protein is also known as VP1. All of the birnavirus VP1 proteins contain conserved RdRp motifs that reside in the catalytic "palm" domain of all classes of polymerases. However, the birnavirus RdRps lack the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RdRps [1].	25.00	25.00	33.30	30.80	17.20	17.10	hmmbuild  -o /dev/null HMM SEED	860	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.67	0.70	-6.51	5	338	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	26	27	0	228	0	401.50	68	97.83	CHANGED	MSDVFNSPQsRuoIosALGhKssuupDlc-lLlP+pasPPcDPlsus...pcAApaL+-NpY+lL+PRuIPE..Np.l-TDsh.hP+Lsph..l-...sGcLtDT..VSlPtGoocaIPKYYPsHKPo+pcsssa.PPDlTLLKQhoYpLLpss-so-Npt......-Tl+pLpcAIsTppYGSGShpGQlsRLlAMKEVATGR...NPNKoPKclGY.ThEclAchLDpTLPIsPPtsDDc.hlsLossLSaLl.hTsDsuss...cDYLP+IThKSSAGLPalGKTKGETssp.ALsluDpFLR-VSphLK-GAsTuuss.........................cpcLc+lLsDYWYLSCGLLFPKuERY-pscWLTKTRNIWSAPaPTHLLLSsISsPlMcsShNNlhNs.cTPSLYKFNPF+GGM-sIVshI...Lus.sEslhLVYADNIYIhh-N.....TWYSIDLEKGEANCTP-HAQAsuYYLLTRGWTs--GoPtFNsTWAThAMplAPuMVVDSSCLLMNLQlKTYGQGSGNAWTFLNNHLLSTIVVsKWscsGpP...................NPsSKEFtcLEutTGINFKIERsIcsLRpKLpEAscpAspsGYL.S-GoE.PPcpPuPTVELDLLGWSATYS+ah-hFVPVLDKERLasSAAYPKGlENKsLcuKsG...AEQAYKlVRYEALRhVGGWNYPLIspAscssAps+Rs+....LcsKGhsLDchlu-..Wsc..h.SEFGEslEslol..ccsVTspsLt-LNtsscshcPsVs+shsRs...sL+cVoNALppGsYKsspossGchLsstA+SRI.....ps.h...+scslt-pls+LKPscscuDsWs-RsEptustlctLh+AsslhcppLcEsucALEsVQ......SscllsuKpPpEKssppAoNPVVGY+..uc+h...........sShP...p..sLoPsu+KttKRRpKQ+cp	..................................................................................Pp....EhEsDQI.LPD.....LAWMR..QIE....GAVLKPT.....LSLPIGDQEYFPKYYPTHRPSKEKPNAY.PPDIALLKQMIYLFLQVPEAs-sLK...................DEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGR...NPNKDPLKLGY.TFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLshTGDsss-........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1382	PF01766	Birna_VP2		Birnavirus VP2 protein	Bateman A	anon	Pfam-B_946 (release 4.2)	Family	VP2 is the major structural protein of birnaviruses [2]. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].	19.70	19.70	21.60	21.10	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.32	0.70	-5.56	4	2317	2012-10-04 01:49:40	2003-04-07 12:59:11	12	5	39	48	0	1558	7	234.70	75	85.90	CHANGED	ppspspYL+SLLhPpsGsuSIPDDhhtRHsL+sEToTYNLpsusoGSGLIVhFPssPuSllGAHYphsuss.shhFDQhlhTuQ-LKcuYNYuRLlSRplsV+SSTLPAGVYALNGThNAVTFpGSLSElpDhSYNuLhShTuN.pDKVGNVLVG-GVsVLSLPsGaDhPYVRLGDcsPth.pSs.thsspCssuspPRtYpIssss.......V.ssGspsphauhNlDulsssslss-hphphpsps.hshshpsh.luhsGhssssRslohossshusTspa......hstlhspspITpPlsulKlphph....u.tsusshu.sssSSluloltGGNhPGsLRPlTlVAYEpVAsGSllTluGlSNYELIPNPELtKNlsTpYG+hDPtshsYsKhILScR-cLGlRoVWsht-Yp-hppYFpEloDhsSsL+hAuAFGatDll+uIR	...........................................................................................................................................................................................................................apIshusph......s.YQsGGV...TITLF.SANIDAITSLSlG.GELV.FQT....SV.Qu...LlLGATIYLIGFDG..TAVITRA....VAAsNGLTAGTDNL....MPFNlVI....PTsEITQPITSIKLEIVTS...........KSGGQAGDQMSWSAS.GSLAVTIH..GGNYP.GALRPVTLVAY.................................................................................................................	0	0	0	0
+1383	PF01767	Birna_VP3		Birnavirus VP3 protein	Bateman A	anon	Pfam-B_946 (release 4.2)	Family	VP3 is a minor structural component of the virus. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].	20.80	20.80	29.10	28.50	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.65	0.70	-4.75	5	161	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	30	2	0	176	0	219.30	65	23.46	CHANGED	lcYLs.......cLtMsosuSutcPELEcslcAhMAcA+clPsup..................KlLsLhSWsRcNuLlDcMacWAp.........pDPcAlRhcRhLuNsP+cGpKspctKhhsts....uKGPTpcs.......AQ-AKAsRISpDAscsGt-FATPEWVA..pNsaRGPoPGQhKYYhtTGhsP-PG--YpDYl+psloRPss-sKItRLAsSlYGhPsQEPAP--FhDtVAcVas-NsGRGPsQ-QM+DLRctARcMK+R	.....................L.PYLPPsAGRQ..acLAMAASEFKETPELESAVRAMEAAAsVDPLFQ..................SALsVhhWLcc...N..GllscMssFuh.........oDPsAcRhcshLussPptupK........ts....s+GPT.cc.......AQ+tKsTRIStch.shGh.FATPEWVA..LNGaRGPSPGQhKYapsTtclPDPNE-Y.DYV+s.ppoRhss--pIhRhAsSlYGsPsQs.sPpsFlDcVAcVY-.NcGRGPsQEQM+DLh.tAhcMK+R.......................	0	0	0	0
+1384	PF01768	Birna_VP4		Birnavirus VP4 protein	Bateman A	anon	Pfam-B_946 (release 4.2)	Family	VP4 is a viral protease [1]. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].	21.20	21.20	21.20	22.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.62	0.70	-5.33	4	354	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	42	21	0	303	3	175.60	57	29.75	CHANGED	VAsPVlSTLFP.AAPLIGAADphlssLhtssAuuGRhsu+AAuG+h+ss.cphtsho.suphuhplcspL........EssNapcs-l.+s.........ppuslFPVVhTs...cssPu-s.uphhsVI.Gth.-L.sPNQpshshaphsstpVaGhupD..lPhEssc.sYTsLPlc-l.hsGsIslpK..hsPlhGsSuQLAI.hhssslcpGV....Ph.hsFTGplsts..olh.IpGVsl...KhhsAHcLGLPLlGspPGls-hsssTSLAs+lh	.............lAsPVlSTLFP.AAPLhtAhsphls.LhtspAtuuphpu+AAuG+h+ss.sphtpho....suchuhplhspL.........ss...htpstl..s.................lhPVlh.............................................................................................................................................................................................................	0	0	0	0
+1385	PF03042	Birna_VP5		Birnavirus VP5 protein	Bateman A	anon	Pfam-B_1772 (release 6.4)	Family	Birnaviruses are ds RNA viruses. Non structural protein VP5 is found in RNA segment A. The function of this small viral protein is unknown. The proteins are about 150 amino acids long and contain several conserved histidines and cysteines that might form a zinc binding site (Bateman A pers. obs.).	25.00	25.00	33.40	39.90	19.50	18.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.73	0.71	-4.66	7	113	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	16	0	0	102	0	123.50	64	94.44	CHANGED	hpDEHppuNRNLhElHYASRDWss+...HSGRHNtEsHsKTRDLVlQh..RGhRlRKhsSCLhPWtohlpstCoLQsEsEPDGstlRPVAsDlsGPcEulQLhEAslpEIR+scLHsstWsLCochD.cRpcLRRpSl	.sDc.s+uN.s.spVHstspDANsRTGVHSGRHPtEAHoQVRDLDLQhDCtGaRVR..AsCLFPWhPWLsCtCSLHs.AEQWEhpVRssAPDssEPstpLQLLQASEoEs+ppVKHTsWWp.LCTKhc+KRRDLPRKP..	0	0	0	0
+1386	PF03493	BK_channel_a		Calcium-activated BK potassium channel alpha subunit	Griffiths-Jones SR	anon	PRINTS	Family	\N	26.80	26.80	27.50	26.90	26.00	26.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.24	0.72	-4.06	35	665	2009-09-11 05:04:26	2003-04-07 12:59:11	13	15	154	10	289	608	6	99.50	40	9.24	CHANGED	shsphhhphs.-pllslpElKhsllApsslsPGhsTllsNLlpopp......phss.t..........ppWhspYhpGhtp-Iaphtl.sspF....hGhoFsplsthhacphsllLlGlE	..................................................s..spaphK.u..DcslChsEhKhuh..............lAps.C.l.sPGhSThlssLhphpp..........h.ch.pp..............................................-pW.p+hYhcusu.NEhYs.hL..sSsF.................hGhSFstss.hsatKh..t..lhLIulc.........................................	0	105	144	218
+1387	PF04940	BLUF		Sensors of blue-light using FAD	Yeats C	anon	Gomelsky M, Klug G	Domain	The BLUF domain has been shown to bind FAD in the AppA protein (Swiss:Q53119). AppA is  involved in the repression of photosynthesis genes in response to blue-light.	25.00	25.00	27.00	26.20	23.40	23.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.76	0.72	-4.26	154	831	2009-01-15 18:05:59	2003-04-07 12:59:11	7	19	584	55	218	692	223	91.60	38	33.13	CHANGED	LhpLlY..hS.........ps.p.shs......tppltsIlppupppNtptslTGhLla......s..sshFhQhLEGscpsVppla.p+IppDsRHpslthlttp.l.spRtFss.WsMsh	.............................LhpLlY..tS.........ch..pss.hs.......spclppllshApppNhpsslTGlLla........s..sspFhQlLEGs.c-pVptla.cpIppDsRHtsls.Lh.p.c...h...stRpFuc.huMt.h..........	0	55	135	179
+1388	PF02608	Bmp		Basic membrane protein	Bashton M, Bateman A	anon	COG1744	Family	This is a family of basic membrane lipoproteins form Borrelia and various putative lipoproteins form other bacteria.  All of these proteins are  outer membrane proteins and are thus antigenic in nature when possessed by the pathogenic members of the family.  One protein Swiss:032436 is a transcriptional activator [2].	20.80	20.80	20.80	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.58	0.70	-5.68	13	3407	2012-10-02 13:57:41	2003-04-07 12:59:11	9	10	1918	5	933	2720	1656	294.70	25	81.15	CHANGED	hhhlulhssGslsDKuFsppua-Glp+hpcch..slchhhtsust...............sshhsshpplpcpshDLIhssGaths-slptlusch..........PchpFhllDuhhpp-...............NlsolsFRspEuuFLsGhhAAhho+psphualu....................GhphshhpsFhhG.FctGs+YsN.....clclhsphssoasDsstupshApphhp.cGlcVIas..huGhsshGVhpsA+-hG.p......hsIGhDpDQ.....uahuscsllsSslpslschhhphhpphhpss..h.sGpshphGL+cusVGhs................c..chh.schhcchlphtpKhl.ttl.lsspc	.............................................................................................................h...shlhssG.slsDpSFNpus.h.p.G...hp..th...tcc....h........s......l...c....h..t....h..h.p.shs.....................................................t.s.-.h..t.s..s.l.p.p.h.....s.p....s.....u.h.....slIh..u.s.Gatht......s.s.l......t......p...s......Apca.............Pc..h.p.F..s..l.l...D....s...h...hp.sp............................Nlsohsa.pppE.uuYL.uG....hhAu..........h.....h.o.....K........o........s.......p.....l.....G.....a..lG...................................................G....h..p..h..s..h.l..pcF....sG..F....t....t.Gs....c....ss....s.........................ssl..p........l........t......s.......p.......a.............s......s...............s.......a...............s.....D......s....s....K....u..cphA.p..u.hhs...pGs......D..llap.........suG.ss.G.sGl...h.ps.A.cp.t.sth.......................................sIG.VDp.DQ..................s.t.h...s.....s.....p....s......l.....l.s..S.s.l.c....p.h.ss.shhphs.pp....hh....c...u....p...................t.......u.......p....h......h....h...h...GL.c-.s..u...V.s.ls.........................................p...h.s..t...p..h...h...p.t...h.......p.......t..............t..................................................................................................................................	0	342	623	769
+1389	PF01722	BolA		BolA-like protein	Bashton M, Bateman A	anon	Pfam-B_1996 (release 4.1)	Family	This family consist of the morphoprotein BolA from E. coli and its various homologues. In E. coli over expression of this protein causes round morphology and may be involved in  switching the cell between elongation and septation systems during  cell division [1]. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase [1]. BolA is also induced by stress during early stages of  growth [1] and may have a general role in stress response.  It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [2,1].	25.70	25.70	25.70	25.80	25.60	25.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.54	0.72	-4.02	238	4233	2009-01-15 18:05:59	2003-04-07 12:59:11	13	22	2088	10	1342	2705	2605	73.30	33	73.74	CHANGED	p.Lppsl.ssp.p.lpVps.S...............................tsHFclhlVSstF.pGhshlpRH+hVassLt-.cl..sss....lHALul.+.shT.PpEa	................................................h.lppuh.sst.p.lcV...ps.u..........................tG..toHFplhlVSctF.pG.h.shlp+HphVYssLt-pl..sss....lHAL.u.l.+.shTPpEa..............	0	378	743	1064
+1390	PF02044	Bombesin		Bombesin-like peptide	Mian N, Bateman A	anon	IPR000874	Family	\N	18.10	18.10	19.60	18.40	16.80	16.60	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.87	0.72	-5.80	0.72	-4.41	12	105	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	53	2	39	125	0	13.20	79	12.60	CHANGED	GspWAVGHhMGKKS	.GNpWAlGHhMGKKS	0	2	5	9
+1391	PF02414	Borrelia_orfA		Borrelia ORF-A	Bateman A	anon	Pfam-B_1805 (release 5.4)	Family	This protein is encoded by an open reading frame in plasmid borne DNA repeats of Borrelia species. This protein is known as ORF-A [1]. The function of this putative protein is unknown.	19.60	19.60	20.70	20.50	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.19	0.70	-5.30	25	681	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	33	0	37	578	2	235.80	31	82.34	CHANGED	KhQaK...LIsLISTLpYlNpphKK.....................YoQpsILYaFNpNLKRNGQ+slplKTLQpYLY+L-K.hpVTp...NYa+HLG.lNh...GTEIYYKLpasKcc.CaphIN.pYFc-+Kcp+apsRl..........sshh..pcchsKpssVpht....................................................EChsNps.s..NK...cEc..pKptc..IEchplpKYhpKCNFhsp.........llpLplpK-tpIclhKhhK+hE.tlhK..................................p.hph.c...pphKsKpppLKpILpNh+..hphcpcsYspcQLcpphpchYc.pYKsKPHFIIEppKYs..DLspI.htKlKcshcpp.Kpsspcshp.pIKsNI.........aN	................ph.hK...ll.lhusl.alNpph.....cc.....................YsQpsILhhhNpNLp+ss.p.ssl+Thpp.LhhLp+hhtlp....sahpphG.hsp....Go..h.aYclph.h........p.s......aphIs.paFpppctphhpphh.........................pt.h......ppph....p.t.s.lp...........................................................................................................................................................................................................psh.spp......sh..hpp...+.....h.p....p.p...........p...h..tp.sh...................ppt.h..hphhp..p...c.tlh+.............................................h.....phpp.pppph+phL.shp..hph.pptYp.cpl...h.p.hp..YK.K.ahhhcptchp..Dh..l.htchccpht.p...Kpp..pps.p..php..h.........................	1	29	29	29
+1392	PF03183	Borrelia_rep		Borrelia repeat protein	Mifsud W	anon	Pfam-B_2029 (release 6.5)	Repeat	\N	20.60	20.60	23.00	20.90	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.02	0.73	-6.24	0.73	-3.84	14	96	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	5	0	0	96	0	18.00	64	43.37	CHANGED	TlSILlS+SLhoDhp.h.	TlSILLSRSLhSDFsShh....	0	0	0	0
+1393	PF00228	Bowman-Birk_leg		Bowman-Birk serine protease inhibitor family	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	22.20	20.80	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-7.35	0.72	-4.08	55	570	2009-01-15 18:05:59	2003-04-07 12:59:11	15	4	80	50	85	586	0	25.90	43	37.76	CHANGED	sCcsChCoc.....ShPPpCpCtDhhpt.Ch	.sCcpC.h.CTc.....ShPPpCpCsDht.t.Ca....	0	0	20	52
+1394	PF02653	BPD_transp_2		Branched-chain amino acid transport system / permease component	Bashton M, Bateman A	anon	COG0559 & Pfam-B_654 (Release 7.5)	Family	This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH Swiss:P08340 and LivM  Swiss:P22729 both of which are form the LIV-I transport system [3]. Also found with in this family are proteins from the galactose transport system permease [2] and a ribose transport system [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.59	0.70	-5.43	51	33622	2012-10-02 17:14:55	2003-04-07 12:59:11	11	38	3614	0	9346	25680	15397	275.60	20	80.62	CHANGED	tlhshlthus.lslhuluhslsh.hsGhhsluhuuhhshu.uhssshhhthhs.......................................hhlullhuhlsusshGhlsuhlhhthplspl.........lsolh..................hhhhhhulshhhhtthhts.tsss.....h.sshhsh.sshhh.hshthhh..........................................................................lhhllhsllhhhllt+TphGhtlpAlGps......puAchsGlslp+hphhsasloGhhAuluGhlhshhhsss........shuhs....hthtslsssllGGs........ssshGslluullluhlps.shshhth.....................sthttllhGhlllhsl	.....................................................................................................h...shltt.ssh.h.sll..A...l..G..h..s..l..l......h..h.......s.......G.......h.......l.....s.......luhu.u.hh.slu...u...h..s....s..s...h.h...h..t..t.h.s.....................................................................................hhl.u.l..l.....h.u..h....l....s..u....s........l..h.....G.....h.....l....h.....G.....h.....h.....h.....h.....+.......h......p.......h.....s...........h.................l..s...o..l..h.............................................................h..h..h...h...h....h.....s...l....s.....h..................h......h.........t......t......h...h....s....s....s.....t....s.....s...................h.h.t...s...h....h....t.....h......h....h...h.....h.....h....s.....h..h.......h.hh....................................................................................................................................hl..h..l....l....l...s...h...h..h...h...h.....h....l....p....+....T...p...hG..pt...lhA..lu....ps......pu.A.chhG.lss.p+hphhsasluuh.lAul...A..G.s..l.h..u.t....t..h.s.s.sss..........shu..h.s.........h.t.l..p..u..lss...sl.......lGGh..................Gsl.h.G.s....l..l..G.u....l....l....l..u....h.....l....p.s......s...h...s..h.hsh........................................s...................s.hp.....l...l.h.uhlllhh.........................................................................................	0	2466	5546	7467
+1395	PF00634	BRCA2	BRCA2_repeat;	BRCA2 repeat	Bateman A	anon	Prosite	Family	The alignment covers only the most conserved region of the repeat.	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.08	0.72	-4.65	25	1602	2009-01-15 18:05:59	2003-04-07 12:59:11	13	37	218	1	293	1604	4	33.50	36	11.38	CHANGED	hcsshsuFpTASGKplsVScpoLpKu+plhs-hct	...........s.hhuFpTASG.K.plp.VScpuLpKu+pl..Fp-hp.............	0	99	128	183
+1396	PF02498	Bro-N	BRO; 	BRO family, N-terminal domain	Mian N, Bateman A	anon	Pfam-B_1235 (release 5.4)	Family	This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown.  It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription [1]. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins [2].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.92	0.72	-3.70	257	2580	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	1532	0	314	2002	73	91.30	24	37.17	CHANGED	pl+slh......psschWasup-ls.psL..sa........sss.p........csh......hpcl.cc............ptp..h..................................st........................h............hhlscsGlapLlhpS......c........hs.....p..AcpFppWlh...p-llP	......................................lRhlh....ssc..a.FsupDls.phL....sa....................sss..t...............csl......tppl.cp...............cpp.tth.....tp...........p..............s.ut....t.........................................................pp..h...............hhlsEsGlYpLl.h.pu..c...............hs...............p..AcpFppWlh....ppllP............................................................	0	99	222	272
+1397	PF03032	Brevenin		Brevenin/esculentin/gaegurin/rugosin family	Griffiths-Jones SR	anon	Pfam-B_1232 (release 6.4)	Family	This family contains a number of defence peptides secreted from the skin of amphibians, including the opiate-like dermorphins and deltorphins, and the antimicrobial  dermoseptins and temporins. The alignment for this family includes the signal peptide.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.63	0.72	-4.12	19	1689	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	76	0	1	1661	2	43.60	54	62.46	CHANGED	shLKKSLhLlLFLGhVSLSlCEEEKc.-sE...sc-cpct-cpp...Eh+R	...........FThKKSLLLLFFLGT.ISLS.LC.E..c...ERs.AD.EE-..tc-tpp.c..........c........................................	0	0	0	1
+1398	PF01318	Bromo_coat	Bromo_CP; 	Bromovirus coat protein	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	25.50	245.80	20.40	24.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.01	0.71	-4.59	3	16	2012-10-04 01:49:40	2003-04-07 12:59:11	13	1	6	39	0	19	0	188.60	71	99.28	CHANGED	STSGTGK.LTRAQRRAAAR+N.RhT+cVQPVIVEPLASGQGKAIKAhTGYSVSKWsASssAlcAKsTsAlSIoLPcELSSE+NKpLKVGRVLLWLGLLPSVAGTVKuCVTEKQsoAAASFQVALAVADSSKEVVAAMYsDAFKGlTLGDLpsDLoIYLYSSAALsAsuVlVHLEVEHVRPTFDDpFTPVY	.STsGTGK.hTRAQRRAAAR+N...R..pTphV...QPVIVEPlASGQGKAIKAhsGYSlSKWpASssAhp.AKsTsAloIoLPsELSSE+NKpLKVGRVLLWLGLLPSVuGpVKuCVTEpQssAuAuFQVALAVADsSK-VVAAMYs-AFKGlTLtpLhscLpIYLYSStAlsAtsVlVHLEVEHVRPTFDDhFTPVY..	0	0	0	0
+1399	PF01573	Bromo_MP		Bromovirus movement protein	Bateman A	anon	Pfam-B_508 (release 4.1)	Family	\N	25.00	25.00	26.20	26.60	17.80	17.30	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.50	0.70	-5.42	16	150	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	28	0	0	151	0	263.30	43	94.53	CHANGED	ssppulol...otc-.ppL.cplscshpsshtpshsh+tCsshthp.Nssuhpsh-LsoK-s+uhlo..+hssKl+pplhVcHshIaLlYlPhILpoTsussslKLhNhATG-chslGsphsLNcAFIlthsWPRSlhscss.pt+GLaLshpss.Assl.ssutlGphhPhW--sho.tK.hYpcsss.hshsht-s.ss+.lhocKhhpSLlpSphptshsuppcts.hlps.plp..cph....cFTlpphp.ssss...........tspstppstlsstpshh-pshsss	..................P.SoSsFSV...Sh.D-hspluc-lcclh.usphpslsTKtCahLpLl.NhstsssLcLsSKEpKuFLo..R.uDKVKp+lYhshutlaLlYlPlI.s..TTSGllTLKLpNssTGEhsDVsTDV-AN+AFllhsRWsRSLhtsA.....-LsLlholS..sscV+ssA+VGchhsFWDE+hS.+pQhY.-cuNslhFPItETcss+hlsscKlLhShVRSRlhsGspupc.hs.spslpscRlussc+s.....hTlp.tsshsc-............hcstspshsusscshhE-thh...................................	0	0	0	0
+1400	PF04450	BSP		Peptidase of plants and bacteria	Finn RD	anon	Pfam-B_5066 (release 7.5)	Family	These basic secretory proteins (BSPs) are believed to be part of the plants defence mechanism against pathogens [1]. 	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.54	0.71	-4.86	24	266	2012-10-03 04:41:15	2003-04-07 12:59:11	7	11	162	0	155	275	4	193.70	30	72.57	CHANGED	tsslphclps..s.sosGupp.......................Ftphl...s.uppsLssAsphlhphh.ps..ss-+......................ss..csVTl......hlcDh-GVAhooG.....................ppI+hSspYltshss..scs+....tElsGVLhHElsHsaQass..............ps.pssuGLIEGIADaVRL+AGhsss+WtpPusG.........scWD.pGYphTAhFL-ah-s..hs.GFVuclNcch.+ssY...........s-saahplh.Gcs..VppLWp-Y	.........................................................h...h.hp.ps....pp.u.uthF.p.l......stphltpu.hthlhphh.ps..stsp...........................ss..ppVsh..............hl.c.s....h..sG.VAassG.....................ppIahSspaltphs.......sphp........tEltGVLhHEhs.Hs...aQass................................ps..psPuuLIEGIADaVRL.c...u.u..h..s..s..s..p.....Wt.p..ss..tu..................ppW-.pGYphTAhFLsalcs.....ht.uhVtplNcph....csta....................................pcshahplh.Gps.....lcpLWp-Y..................................................................................	0	33	107	133
+1402	PF00779	BTK		BTK motif	SMART	anon	Alignment kindly provided by SMART	Motif	Zinc-binding motif containing conserved cysteines and a histidine. Always found C-terminal to PH domains. The crystal structure [1] shows this motif packs against the PH domain. The PH+Btk module pair has been called the Tec homology (TH) region [3].	21.80	21.80	21.90	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.86	0.72	-4.33	26	515	2009-01-15 18:05:59	2003-04-07 12:59:11	14	28	86	12	259	461	0	31.70	38	4.63	CHANGED	ppYHPshah..sGcWhCCppss+sAsGCshssst	...............pYHPuhah..sG+WhCCpQs....s+sA.GCphhps.t.......	0	41	60	128
+1403	PF04514	BTV_NS2		Bluetongue virus non-structural protein NS2	Kerrison ND	anon	DOMO:DM04350;	Family	This family includes NS2 proteins from other members of the Orbivirus genus.  NS2 is a non-specific single-stranded RNA-binding protein that forms large homomultimers and accumulates in viral inclusion bodies of infected cells. Three RNA binding regions have been identified in Bluetongue virus serotype 17 (Swiss:P33473) at residues 2-11, 153-166 and 274-286 [1]. NS2 multimers also possess nucleotidyl phosphatase activity [2]. The precise function of NS2 is not known, but it may be involved in the transport and condensation of viral mRNAs [1].	25.00	25.00	83.80	37.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.37	0.70	-5.57	5	118	2009-09-11 00:56:28	2003-04-07 12:59:11	7	2	50	2	0	126	0	347.00	51	97.69	CHANGED	MEQ..KQRRFTKNVFVLDtppKTlCGpIAstsupPYCQIKIGRshAl+sVsTPEPKGYVLEIs-sGuYRIQDGsDIISLMISs-GVEuTTERWEEWKFEuloslPMAssVslNG.......spsDAEIKYsKGMGlVPPYTRNDFDRREhP-LPGVp+ScYDVRELRQKIREEREKusccpsppsuhKsE....RhhttscsD-DpsshsptAs-hsPcTp+p-pccERRcsltp+lt-t.p....hphp.-c+cc-h++cpcppcsscscSD-s.......D-cGEDS-...--EscscoYITpsYIERIu+l+KhKDERLSuLAStMPQsuGcassMIFoKKpKW-NVPLYsIDEsuK+YELQSVGuC-RVAFVSKGhSLIILPVuu	.................................................MEQ..KQR+FTKNlFVLDhstKTlCGtIA+tsSpPYCQIKIGRslAh+sVpsPEPKGYVLplsssGAYRIQDGpDlISLMlTspGVEuTpERWEEWKFEulSssPMATtVphNGshVDAEIKYsKGMGlV.PYhRN.D.F.DR.pEMP-LPGVh+S..sY...D...VRELRQKIKpEREuusch...p.pul....us+pE....sRWh......D-DEsplDEtup-hhP.tst+l-p.cEtRsslh+clttt.........hphs.pE+pct.+sEp-...cp-phps.SDc..........DEpsEDup...--E.cPcoaITcEYIE+luK.hKhK..DERh.SLuStMPQsuGsas+hIhoKKhKWpNVPLYsaDEuoK+YELQsVGuC-RVAFVSKDhSLIILPVG.V.................................................................................................................................................................................................................................	0	0	0	0
+1404	PF04426	Bul1_C		Bul1 C terminus	Kerrison ND	anon	DOMO:DM04045;	Family	This family contains the C terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524) [1].  The complex containing Bul1 and Rsp5 is involved in  intracellular trafficking of the general amino acid permease Gap1 [2], degradation of Rog1 in cooperation with Bul2 and GSK-3 [3], and  mitochondrial inheritance [4]. Bul1 may contain HEAT repeats.	24.20	24.20	24.20	24.70	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.71	0.70	-5.20	17	182	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	62	0	117	183	0	186.50	20	30.29	CHANGED	HDQENWhpLhphls-pE+psLpcLslpLoCIQSNNShsH.sPPcIpSlTTELlCITu+SDN.SIPIKLsuchLh.sc-Klssl+psFpsappplp-Ypp+FpcNhcKLN-LYNhs+sh..ssREL+FoDFIosQlhNDlESLuNLcVplpsLpplFKKQhpohcspsp......stssossshtsp..ttsp.......................s.tthhppplhppWhppss.pYcRpls..VNLphNp.cl+ET.........LVPoFESCLCCRFYslRVsIKF-pHlGo.splDlPVsV+ph	..........................................................................................................................s.t.....hptlpsphhshohpo.p..shPh.hp.thhh...tp............................h.............ht......................h.....h..ph..slpshtthp.p.........................................................................................................................................p..t....phpppht......lsl.p.h.tt.....p.s.................llPsFpoChhsRhYhl+lplch.t.p............s........s.......hplclPlplt..............................................	0	11	58	112
+1405	PF04425	Bul1_N		Bul1 N terminus	Kerrison ND	anon	DOMO:DM04045;	Family	This family contains the N terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524) [1].  The complex containing Bul1 and Rsp5 is involved in  intracellular trafficking of the general amino acid permease Gap1 [2], degradation of Rog1 in cooperation with Bul2 and GSK-3 [3], and  mitochondrial inheritance [4]. Bul1 may contain HEAT repeats.	28.70	28.70	29.00	28.70	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.50	0.70	-5.92	27	164	2012-10-02 22:29:00	2003-04-07 12:59:11	7	7	69	0	105	170	0	361.50	28	49.70	CHANGED	ssspshphss.spss....sps.lhDlLPSFcMY.solp++lspushs.Dh+shPPoYp-spsppss................sstsssshs.tp.sh.ssstp..sps.p............................p....p.sl.t.t..................................sht....Dshs..p.pshhlDplapLPKLo......o.Pl-lpI+lTKcsspP.pt.ps-.-ohLKEYosGDlIpGYslIpN+SspslpF-MFYVoLEGhhsll-+..........p+sKpplKRFL+MhDloASWoYsslshusGhp.....hhssphD.hDsshlGLsssRlLpPss+YKKFFhFKlPppLLDssCc.cphhsHsLlPPShGlD+hppts+hptIphNpsLGhGalsh+GoPlL...................TpDhu.-slSIsYol-ARllG+s..................pcsschsIhKEppY.LRlIPhsht........sshhsppsshp........hcslhchlpc+l..pthcclhpclcppcs.lss....-l+spsloush	........................................ttp.............t.ttp.l.slLPSapMa.pslhpph..s...sp...shp......PPsYt....pp.s.......................t.s.t....................t.t.........................................................................................................psht..t.pphhl-plhpLspls......s.slplpIhhT+phs..t......-s.lpEYppGDhlpGahhlpNpSspsl.F-MFhVshEuhhphhsp..............tt.hph++FLcMhDhsASW.s.spls..ss.p........hh...hD.hDsshhulsssRlLpPshpYK+FFsFKlPppLLDssCp.p..p......h......h......s......Hs.hLPPohGls+.hp..sphtthths..p...........................s.h.............................hpDhu.tshSlsYslpA+hlG+t...........................psschhlhcEtph.lRllPhsh.........t....t.ps.........hpsh.p.lpp+h......thhppl.pthp.t...................h..............................................................................................	0	10	51	98
+1406	PF03557	Bunya_G1		Bunyavirus glycoprotein G1	Bateman A	anon	Pfam-B_653 (release 7.0)	Family	Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G1 glycoprotein which is the viral attachment protein [2].	25.00	25.00	31.90	31.90	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	871	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.79	0.70	-13.63	0.70	-6.74	15	361	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	74	0	0	338	0	609.20	35	56.09	CHANGED	YsslAppLtuhstIS.LDhshlshlP--IuuAL+hIEsp+TYHp.lhlEhshLo+YCDYYopFscNSGYSQTsWRhaL+oHcF-lChhaPNpHFC.RClpcusKCssusWDFAsEMpsaYouKps+Fs+DLNLhLpsh+pAFRGTopualsphlpcKcssslhphhsKl+pKaPsNsLLhullcahpYLhuLschosacLsp.Wc-hlapspspppsphs+spcS..YpasNAtssssoKsCcNhKsVsCLSPRuusshsslIACG-sss.plYchPs.plYpSNscpspaClsDoHCLp-FEslspEhLsulKKopCWts-hsshs.cppSsGl+SC+hKDpGsCsVsss+.WsIIpC-sspaYYS-t+csaDpspDIG.HaCLSs+CsT.RYPINPcpIpsCsWphppsphcpIsshsLE-lEpYKKAIopKLpsoLoIa+Yp..TcNLPHIKPlYKYITlpGTETuEGIEuAYIpSpIPALuGTSIGFKIsSKDGppLhDlIsYVKSAsYposYsKlYsTGPTIGINTKHDE+CTGsCPspIsHKsGWLTFu+ERTSoWGCEEFGCLAIssGCVFGSCQDII+sEhsVYRKssEEssslElClTFscKTYCT-lNAlpPIITDchElQFKTV-ohoLPpIlAVpNHclhsGQINDLGsaSpGCGNVQKsNuTshGsGsPKFDYlCHhASRK-VIlRKCFsNsYQuCKhLpp.sShhh--cpsTlTVhchK+lLGslphKhILGDl+YKsFAEslDlpsEGpCsGClsCFEsIpCpFsIcoolEsoCslcusCThFHDRIlIoPsc+cYAlKlhCpcKPssolpFKICNpKl-sshTlVDtcshIELuslDQTuYI+EKD-RCKTWhCRVRDEG	...................................................................................p........hst...pht..t.hp.h.l.ppp....cshcsthhhEahhhthhs..shappa.psuG.sphpWRhhh+spphchC..assphhC.RCl.ptpcCsssphDhupphpphYptppphaptDlplhh..ht..h.t.s..hh....tptt......h..th..t......h..hh.hh.hh.............................................................................................................................................................................................................................................................................................................hsGhu.sa.lps+pupph.h-hlhYlKSsthphshschYsTuPh.uhsspa.phCTGsCs..s..pl.t..t..ssahsFshp.TS.WGCEEhGCLAIspGslhGpCpsl..hc...-..h..t.lYp..p...hppth.s-lClo...tt...shCs....plsshpPh.ss.....hphphp...s...spshslspllul.p.s.pclh.GpIsclGshs.p...h.GpsQh.s.p..s.....s..l.....h.....s...........us...s....c.FD...a....Cp...hhu+Kclhl+pCh.ssYpupphLpp.ssh.....hp.ppts.hhhphph.LGplphhh.Lsc.haK.h.s.p.p..pl.p.s.c.u.pCsGChtChpslpCphphhoshths.ssl...s.s.Cs.ap.s.pl..hlp.sppchslKhhCppp.t.ph.h.lsttp.pht.ph.h.tp.hl-...s..Dp...............................................................	0	0	0	0
+1407	PF03563	Bunya_G2		Bunyavirus glycoprotein G2	Bateman A	anon	Pfam-B_1048 (release 7.0)	Family	Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G2 glycoprotein which interacts with the Pfam:PF03557 G1 glycoprotein [2].	25.00	25.00	30.20	25.60	23.70	18.80	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.98	0.70	-5.52	9	412	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	74	0	0	340	0	233.50	57	29.30	CHANGED	ssshsRCFtGGpLltphpSssuhoElClKDDIShlKSpsha..tKNcssIhussKhaRpahVpDWppCNPl.ssuGoh.Vl-VscshpLhsKsYsCpssCsIol-+-sApIlhposcLNHFElsGTTlpoGWFKsKsoloLDpTCEHl+VTCG+KolpFHACF+pHhSClRFh+poILPt.MhpShCQNIELIIlshhslhhhIhhlILTKTYIsYLLlPlFhPhsalYGhlYN+sCKpCpsCGLAhHPFTsCsopClCGh+apoo-ph+lHRputhCpGYKSLptAR	.....sslhpRCFpsGsllKppsSppuloElCLKDDVShIKopupY..hKNsoGlausNhshRpWlVpDW+-CpPhcssGGpINVIEVscDLoLpTcoYlCoADCoIslDKETAQlhLQT-shNHFEluGTTlKSGWFKoTshITLDpTCEHl+VoCG.KolpFHACFpQHhSClRah+tohLPt.hhpShCpNhElIllh.h.hh.hhhh.lloKTYlsYlhhPlFhPhshhYuh.h.+.hK.C..ChLshHPFo.Cs..ClCG..atso-th+hHR.sh.C.GaKsL.hsR.....	0	0	0	0
+1408	PF01104	Bunya_NS-S		Bunyavirus non-structural protein NS-s	Finn RD, Bateman A	anon	Pfam-B_880 (release 3.0)	Family	The NS-s protein is encoded by the S RNA. This segment also encodes for the N protein.  These two proteins are encoded by overlapping reading frames.	25.00	25.00	33.20	33.20	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.88	0.72	-4.51	24	277	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	72	0	0	221	0	84.00	44	97.52	CHANGED	M.hpshpl+Lhp+psMh+Lplshsps.hhl.LESSoShcRRPKlsshtcpsthhhLhLtuuphpaLIpIFhpTushpC.TosLPSTus.sT	....M.h.t.phcLh.h.thhcL.lshs.p.hLl.LtSSSSh.pRP+LhShhppsshLhLpLtuuphph.IhIFhpTushQhhTTlLPSTss.sh..	0	0	0	0
+1409	PF03231	Bunya_NS-S_2		Bunyavirus non-structural protein NS-S	Bateman A	anon	Pfam-B_3018 (release 6.5)	Family	This family represents the Bunyavirus NS-S family. Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.	25.00	25.00	95.60	95.50	18.40	18.20	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.33	0.70	-5.91	9	245	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	30	0	0	244	0	410.40	68	94.52	CHANGED	MSosphs..................spphhpsYGop.Ds+AlsDsYslas.GcGpphlphhhaoNuthKouFuhsphG+stDlch...........cEtEllsopc.ashF-c...hsLsIshssc.hpllVp+PslpspGsKaphHspIhsPspshLphsss.....hscc-Fhcp.plpppchhPsshhl-tspKsshhlssssphslcYua.sVMGKs...ssa.tpshs+EhllosKpcsh.ssstssNRhLsspsVKuIpIu..S-ltss..opshLps+pshshclpsQh.RlShsulhcEsuhsRhFhls.-spsRhlhh.ucslsspsNtcTTLlIKllsKsh..sphssshsp...shpsChcs......ltsphGlVc.hhssDPs.YNphIs+sLLuVHTphAhslScsLpKPlIVFplhD.pELpscps-lsG+plsYpcDupGshYFLSpTL-.....hhPps.oolsYLsSht.s.WK.shstpchhlp	..................MSSSVYE................SIIQTRASVWGSTASGKAVVDSYWIHELGTGSpLVQ...TQLYSDSRSKSSFGY..TAKVGDLPC...........EEEEILSQHVYIPIFDD...IDFSINIDDSVLALSVCSNTVNsNGVKHQGHLKVLSP..AQLHSIGS....hMNRSDITDRFQLQEKDIIPNDRYIEAANKGSLSCVKEHTYKIEMCYNQALGKV...NVLSPNRNVHEWLYSFKPsF..NQVESNNRTVNSLAVKSLLMSAENNIMPN..SQAFVKASTDSHFKLSLWL.RV..PKVLKQlSIQKLFKVAGDETNKTFYLSIACIPNHNSVETA..LNIoVICKHQL..PIRKsKAPF...ELSMMFSD......LKEPYNIVH.....DPS.YPQRIVHAL.LETHTSFAQVLCNNLQEDVIIYTLNN.+ELTPGKLDLGERTLNYSEDuhKRKYFLSKTLE.....CLPSNTQTMSYLDSIQIPSWKIDFARGEIKIS.....	0	0	0	0
+1411	PF00952	Bunya_nucleocap		Bunyavirus nucleocapsid (N) protein	Finn RD, Bateman A	anon	Pfam-B_587 (release 3.0)	Family	The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein  is encode on the small (S) genomic RNA. The N protein is the major  component of the nucleocapsids.  This protein is thought to  interact with the L protein, virus RNA and/or other N proteins.	25.00	25.00	27.60	35.70	20.50	24.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.52	0.70	-4.35	17	354	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	96	0	1	246	0	197.20	55	97.72	CHANGED	FpDVPppssuTFDPEAuYluFpspastsLshsslRIFFLNt+KAKssLu+puc.pVsLsFGGhphsVVNsHFPt.psNPVsDsuLTLHRlSGYLARWll-pht.ss.pscpshl+opIlsPlAEspGhTWsDGsphYLuFhPGuEMFLpTFcFYPLsIshaRVh+ctMDspahcKslRQRYuslsA-pWhpp+hsslpuAhpsVspLsWu+ouhSsAARcFLupFGIpl	........F.DVsppssssFDP-suYlsFptpaspsLshssVRlFFLNttKAKssLp+psc.plslsFGshphslVNNHFPt.psNPlssssLTlHRLSGYLARWlh-php.ss.t.cpt.h+ssllsPlAEspGsTWs-.G..s....phYLuFhPGsEMFLpTFcFYPLsIshaRVh+shMDspahcKshRQR.Yu.thsAppWhppchstltsuhpsVtpLtWt+sshSsuARpFLtpFGItl........	0	0	1	1
+1412	PF04196	Bunya_RdRp		Bunyavirus RNA dependent RNA polymerase	Bateman A	anon	Pfam-B_2559 (release 7.3)	Family	The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein is encode on the small (S) genomic RNA. The L segment codes for an RNA polymerase. This family contains the RNA dependent RNA polymerase on the L segment.	31.30	31.30	31.40	31.40	29.90	30.40	hmmbuild  -o /dev/null HMM SEED	743	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.13	0.70	-6.52	12	767	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	282	0	0	649	0	428.70	23	35.15	CHANGED	lshsRh.slhhu.p....hFh....ptshhhh.tps......s.hsh..shpphhp...hphLlslh.cK.phhtlhs.hR.Ylhhtshs.hSsh.chI.chF-c..psshshhhshhIKphlhshtp.sppshh..lplsshshp.pslts.tlhs.shh.tshhs.hcsLlsphYhshYhhsKshcschss.splhpchlEaEpchpppp..........phhth.............h+.hscuhhtphpppsthc..lc.ppsFppslsplushphsphshp.....p.pslcu..o.hscch.chps.ppht..p.........cthphphtccs........ahhupsls.....................hlpshhhsphsppp.shVlchhcpshphhchtp.........hp.hhhKtppptu...RthFltsl.p+lhhth.lEchscslh+hsspEhhopsts+c.hhlppthphth+atstcohhplupuDsu.................................hhsphhalotsho+hostsss..ahahhhlhhsslhhpKchhhslphlp.h...cp.hhhs-hhhphlcpthphpp..sh..ahstshs..hhtsctsahQG.LsasSSLhHush..ha+chht....cth.pl-..........shhchhppSDDuth.luh.t.spsttsphthl................phspthFphtcthhhhhsIh.hs.KpThso..s.hEFhSpF...FpGsshs..hh+hlhsulscstt.shhsDltphpsphsphlctGssspLs.ls.sspp.hshphYu.sssu.hss.tphlph.ps.....phPh.hhhhhstPhtththhGhphss	..............................................................................................................................................................................................................................................................p....h.s..h..................th.....................................................h.....h...h...............tp.h.t..........t................................................................ht.pt...............h.t.h...................................................................h.p..t.......hl.p......t.h..................h.......h...p.t...+.hal..h...h...h...th..thh....pch.t....t..........h....t....h..t.........p.....................................hht.h..hst.h.hhs....s..hhhhhhhhh.uhhpp+hh.hslphlh.h........cp.h..pc.hh.hh.t..thp...ph..hhp.h.....p.....h.hptshhQG.hphsSShhtshh..hhpph.......phh..h...............hhhp.h.tSsss...h......................................................................................................................................................................................................................................	0	0	0	0
+1413	PF03181	BURP		BURP domain	Mifsud W	anon	Pfam-B_1432 (release 6.5)	Family	The BURP domain is found at the C-terminus of several different plant proteins. It was named after the proteins in which it was first  identified: the BNM2 clone-derived protein from Brassica napus Swiss:O65009; USPs and USP-like proteins Swiss:P21746 Swiss:P21747 Swiss:Q06765  Swiss:O24482; RD22 from Arabidopsis thaliana Swiss:Q08298; and PG1beta from Lycopersicon esculentum Swiss:Q40161. This domain is around 230 amino acid residues long. It possesses the following conserved features: two phenylalanine residues at its N-terminus; two cysteine residues; and four repeated cysteine-histidine motifs, arranged as: CH-X(10)-CH-X(25-27)-CH-X(25-26)-CH, where X can be any amino acid [1]. The function of this domain is unknown.	20.70	20.70	21.00	21.00	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.91	0.70	-5.17	28	407	2009-09-10 21:17:04	2003-04-07 12:59:11	10	6	56	0	178	416	0	183.20	34	55.05	CHANGED	ulFFhEccL+sGsphs....ltFssssst...s..sFLPRphAcslPFSopcls-ILphFultssSspActhpsTlpcCE.ssu..hcGEcK.....hCATSLESMVDFusSpLGsp.slpAhS.Tts.s......tsstppYsl..suV+tls.u..t...sssVuCHp.sYPYsVFYCHpstp.o+AYtVsLhus-Gs.........tscAVAVCHpDTSsWsPp.HsAFplLsl+PGslPVCHFlspscllWs.p	...........................................s.haFh.p.lh..Gphh........hst.t...............hLs+t.....uppl.P.Fstpphstlhth.hsh..so..u.phhppslppC-...tss.......htGE..pK.....hCsoSlEshl-FshuhL...G...p........plp.......sho..oph.t........................hppYtl..tsV.pt..l.....s..s...............sp.VsCHp.sa....P....Ys.VaYCHp.h.........tt..s+sY.Vs.lhus.cus..............tspulAlCHhDTSt.Wssp.HhuFphLtscPG..p.s.s.....VCHalspsp.hlWs...........................	0	15	102	151
+1414	PF03309	Pan_kinase	Bvg_acc_factor;	Type III pantothenate kinase	Mifsud W	anon	Pfam-B_3452 (release 6.5)	Family	Type III pantothenate kinase catalyses the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.	23.30	23.30	24.50	24.40	23.10	23.00	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.49	0.70	-4.81	194	2298	2012-10-02 23:34:14	2003-04-07 12:59:11	9	5	2191	43	659	1901	2016	197.40	29	75.38	CHANGED	lLslDlGNTplhhulaptt..........thh.....ph+h..sosttps..........t-phshhltshhphtsh..............h..tllluSVVPshhtshtphhtch...ht......hpshh.......ls.sshph.GlshpY.c...sP..pplGuDRllsslAAhp.ha....s.s..hlllDh.GTAsThDsls..scG.p..alGGhIsPGlslthcALtppsApLP..plt...............htps.t..psl...GcsTssulpuGlhaGhsGhl.-tl...lp.......c	......................................................................LhlDlGNTphhhulhptt.................phht......ph+h.....ts.s.h.tpo...................t-ch..s.hh..l...p..phhp.h.tshp..........................tlhluSVV.Ps.h..h.t.s.h.p.p.hh.h.c.h.ht..........hpshh..............ls......s.shps...Gl.s.hta.c..s.P..p.p..lGuD.......RlsssluAhpha.........sts.hlVlDh.GTAsTh-h....ls.........tcG..p......alGGsIsPGltlphcALtppsAp..LP.p.lp...............lsp.s...t......ssl....GpsTssuhpuGlhaGhsGhl.-tllp.p.........................................	0	270	498	593
+1415	PF04681	Bys1		Blastomyces yeast-phase-specific protein	Mifsud W	anon	Pfam-B_5640 (release 7.5)	Family	The molecular function of this protein is not known. Its expression is specific to the high temperature, unicellular yeast morphology (as opposed to the lower temperature, multicellular mycelium form) [1].	20.90	20.90	21.20	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.02	0.71	-4.50	2	111	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	60	0	75	103	0	144.40	33	78.72	CHANGED	ESVlAKRADLGsAFVhlYCNFoVhLDlpAGtsSTR+hLsGRsaDYapE.YtsGSGDGVSLTLpHT-G.DSSNScTTFRYKLuDsNSTVtYSLGNSGGNPFtGHKlTLKsSsDtCPpIEWP-GIPTGVSSGSCGSutNLILThCP.tpshp-FEDE	................................................h..shs..........lGpAhVhN..pCshsVaL.a..Sluusl.us.tp.hl.s.stshphhpp.ha.+..s.s.s.u.GGluLKl.o.p.s.-.G.h..hs.u.ss.pThFsYsLsts......tspVaYDLSslFGs.P.F..sGpp.ls...l...p.......s.....o..ss......sC.....P.sIhW.s.sG.........l.........P.s.........G.s........p..s..p.sCt.ussclhLTLC............t......................................	0	7	27	58
+1416	PF00170	bZIP_1	bZIP;	bZIP transcription factor	Sonnhammer ELL	anon	Prosite	Family	The Pfam entry includes the basic region and the leucine zipper region.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.15	0.72	-4.01	22	5966	2012-10-02 13:17:30	2003-04-07 12:59:11	16	81	523	288	3305	7374	40	61.00	27	17.17	CHANGED	-cplK+p+R+.pNRpuA++sRtRKptchcpLpp+VcsLpsENttLtpclppLccpstpLptpsp	.............................++p+R.hhp.N.R.........t....u..A.....p+sRpRK.c............p...h.......lp.......p.......L.......E...p.......c...l..........p..........p....L....p....p.......p.......N.....p....p....L...p..........p...p.h..p...t...L....pp.p.ht.h.....h...............................................	0	830	1626	2510
+1417	PF00386	C1q		C1q domain	Finn RD	anon	Prosite	Domain	C1q is  a subunit of the C1 enzyme complex that activates the serum complement system.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.82	0.71	-4.13	46	2356	2012-10-01 20:41:10	2003-04-07 12:59:11	16	38	315	47	1129	1977	431	122.60	27	35.37	CHANGED	AFSsshspthsss.t.........slhFcc....llhN.tssYsssTGpFsCslsGlYaFsaplp...shppsltht..Lh+N...spphhthhsptpssp....psuSsuslLpLptGDcVWlplhst...suhhsspt.sposFSGFLl	................................AFpsshsps...h...s........p.........slhF-.p....lh..h.N....h........s...s.....p..Y...s...s.po...G.hFs.ss..l.sGl..Ya....F....saplt..................hpsppl..t.ls.....L.h+N...............s.p.s..h....h...t.s..h.sp.tssp................phuS....s.....u.....s....l....L..p.LptGDpValpl.tt..........puh.h.s.s.t...........th...oo..Fo.GaLl................................................................	0	266	375	622
+1418	PF01413	C4		C-terminal tandem repeated domain in type 4 procollagen	Ponting CP, Schultz J, Bork P	anon	SMART	Domain	Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.	19.70	19.70	32.60	20.30	16.50	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.79	0.71	-4.17	26	1172	2012-10-02 16:37:33	2003-04-07 12:59:11	14	49	94	40	532	965	0	108.20	49	15.42	CHANGED	uhhlshHSQopslPpCPtGhspLWpGYShLhhsu.sscusGQsLuoPGSCLpcFpohPFl.Css.pssCpYhu.NchSaWLoTsp.......tPhs.s.hsG.plcsaISRCpVCpts	.......................hllshHSQo..hp.l..P..p..CP.....t.....GhppLWhGY....S.hLhhpu..spcupGQsLu....osGSCLccFpohPFl.Css..pssCpYhu.NcYS.aWLoTs.......p...........................tP...hs....s.h....s....G.....plcshI.S..RCpVC.t..................................	0	125	159	312
+1419	PF03595	SLAC1	C4dic_mal_tran;	Voltage-dependent anion channel	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Family	This family of transporters has ten alpha helical transmembrane segments [1].  The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterised as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore [2]. Many homologues are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.	26.20	26.20	26.90	26.40	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.30	0.70	-5.79	159	2801	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	2089	12	789	2007	101	296.00	22	86.74	CHANGED	pphsssaFuhsMGhuulu...hh........ht.................h......h.......shhthluthlhhlslhlall..hhhh.hhh...+hlha..p..thttp.........h....pcPlpusFhsshshuh.hhlsshhhhh.....................................hhhluhsLWhhuss.lplhhshhhhh..................thh..t..pt....hphpp..hsPuW...hlPhVushlsussu..shhs.....................hhhhuhhhauhGhhhhlhlhsll.hhRlhhpphhsps...........hhPohhIhluPhuhuhhuhhtls..............................................h....shsshhuhhLhshuhhhhhlhlhthhph..................hph............................sF.shuaWAhoFPlushs...hushph.........sthhs...hthhphluh...................hhhhhhshhhhhlhhtslt	....................................h..hPhshhuhslGhsuhu.h...ht...............................................h............th...t.h.lut..hhhhl.uhllahh.........hlh......+hlha...c.....phhtc.............l....pcPlhushhsshshuh..hll.ss.hhh.h.....................................................h..luh.s.......lWhhuhl..lplshhhhhsh..............................thht..t..t...............h.phcp....hsPuW..hlshVuh.h.lsu.ssu...sshu.........................hh.huhhhhuhGhhhh.hhlhsll...htRL.h.........h..ps.......h.sps...........hpsshhIhhAPhulsssuhhtlst.................................................................s.sshhshh..Lhshuh..hhh.hhhlh.h.h...p.h......hpt............................sF...ssua..h..uaoFPhshhA.suhhph...........uphhp....................s.h.h..chLuh....................h.hlhss.hllhhlhhthl.h..............................	0	203	426	638
+1420	PF01681	C6		C6 domain	Hutter H, Bateman A	anon	Hutter H	Family	This domain of unknown function is found in the C. elegans protein Swiss:Q19522. It is presumed to be an extracellular domain.  The C6 domain contains six conserved cysteine residues in most copies of the domain. However some copies of the domain are missing cysteine residues 1 and 3 suggesting that these form a disulphide bridge.	25.00	25.00	25.10	25.20	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.69	0.72	-3.93	35	172	2009-09-12 03:01:09	2003-04-07 12:59:11	12	10	7	0	169	145	0	94.00	21	48.65	CHANGED	Csssshshuhusspsst.....shsshhssshsso..tsssoohploCsuhss..hpsshhlss........ssssspsus.s.....o.lslshsC..sssuhWhY............sss..pslsol.sC	.........................CpsCs.h.hh....hsts........hsshhshstsss...ssCpsh.sloC.pusss......sps..shhhss..........ssssspsus..u......s.sshslsC...sssu.p.Whh.............hu..pslsslsC...............	0	72	92	169
+1421	PF03596	Cad		Cadmium resistance transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.00	20.00	20.50	20.00	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.28	0.71	-4.60	6	922	2012-10-03 02:02:08	2003-04-07 12:59:11	8	3	734	0	141	604	8	185.00	42	92.57	CHANGED	YhuTulDhLlILhlhFuchKppKphhcIalGQYlGoshLlllSLlhAalls.hlPEcWllGLLGLIPIYLGIKlhIhG-..---EpplhctLpppKhspLhhTVshIThAS.GADNIGlalPYFsTLohspLllslllFlIhIhlLsalup+LAslPpluETlEKYuRWIlslVaIuLGIYIllENsThsslLoh	........................................YhuTulDhLlILhlhF..Ap.hp.p..............p..K...p.............h..h.c.IYhGQ..YLGo.sh.Llh.sS.Llh.AaV.ls.al.Pp.cWl...lGLLGLI.PIaLG....I.....+....h...h........l...........h....s-.............s-..s.E...c...c.....h....hc...p........L........p........t........p..t..........h.............s.............p....L...........l...........hs........VuhlTlAS.GuDNlGlalPYF.soLs.hsplllsLllFllhIhlhshhuphLuslPhl..uEsl.EKapRhlhslVaIuLGlaIlhENsTlphhh.h..........................................	1	36	78	122
+1422	PF00028	Cadherin	cadherin; 	Cadherin domain	Sonnhammer ELL	anon	Swissprot_feature_table	Family	\N	28.80	28.80	28.80	28.80	28.70	28.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.07	0.72	-3.73	57	41902	2012-10-03 16:25:20	2003-04-07 12:59:11	12	548	328	141	21785	37651	1579	93.10	24	44.86	CHANGED	hphplsEst....ushlhplsupDtD...tsssspltYplhpss.....sphFplsspsGp........lpstps..LDcEph.........spYpLplhApDp.........h..shssssplplplt	....................................................hpl.E.s.s..s.......s..G...s.....h......l........h........p.......l........p....A..p...D....t.D..................tu..t..N......u........p........l....p..Y...p...l.....h......s...s.s....................................tshF..p....l..s.......s...p.o.Gt........................................lps.......t....p.......s......L.....D...p..Epp.......................................sp..a.p..l...p....l.p.A...pDt....................ut.s..s...h...s...u....s..s.p.lplpl...................................................	0	4217	6276	12981
+1423	PF01049	Cadherin_C	Cadherin_C_term; 	Cadherin cytoplasmic region	Finn RD, Bateman A	anon	Pfam-B_257 (release 3.0)	Family	Cadherins are vital in cell-cell adhesion during tissue differentiation.  Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the   cadherin.  Cadherins cluster to form foci of homophilic binding units.  A key determinant to the strength of the  binding that it is mediated by cadherins is the juxtamembrane region of the cadherin.  This region induces clustering  and also binds to the protein p120ctn [1].	21.70	21.70	21.90	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.84	0.71	-4.17	64	1652	2009-01-15 18:05:59	2003-04-07 12:59:11	12	99	108	11	822	1256	0	136.60	35	14.31	CHANGED	R++ppp....h...........t.-c...DlR.ENllpY-DEGGGE-...D...ppuaDlssLppshss....................ptshhP.hthhs.................................ssssltpFIpc+lccsDsDPs.uPPaDoLpsYs...YEGsG........SsAGSLSSLs.Sso.o-u-p..caDYL.ssWGPRF+KLA-hYGsp	...................................................................................................................................................p................h...c-.....DlR.-NllpYs-EGGGE-......D.........................pp.taDlu..tLpps.tht.................................................p.s.hP....h.............................................................pssph.tp..FIpp+.l.p.t.A.DpDss...sPPaDoLh......sYs...YEGsG.......................................................SsAuS.LSSLt..S..........so....ss........s.-p.........-.............a..-a.L.s-W.G.PRF+pLA-hYut.t....................................................................................	0	71	138	400
+1424	PF03507	CagA		CagA exotoxin	Bateman A	anon	Pfam-B_918 (release 7.0)	Family	\N	21.60	21.60	21.90	21.60	20.20	21.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.43	0.71	-4.44	4	2702	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	41	4	1	2704	1	133.20	62	54.67	CHANGED	NFSDIKKELNtKL.GNFNNNNN.GLKNSsEPIYApVNKKKsGQsASPEEPIYsQVAKKVsAKIDRLNQIASGLGsVGQAAuF.LK+HcKVDDLSKVGLSASPEPIYATID..DLG.GPFPLKRHDKVDDLSKVGLSREQcLsQKIDNLNQAVSEAKAGaFsNLEQpIDKLKDSTKKNslNLaVEuAKKVPsSLSA	.........................................................ph..tN...N.N.N.N.N.GLKN............EPIYApVNKKK.s.GQss..SPE.EPIYAQVAKKVsAKIDpLNph.sSu..lsthh......p.thsh.hptt..ctVsshSt..s.GpSs....S....P.EPIYATID..-hs....usF.PL+RpstVs.........D.L.S.KVG.LSR............p.Qc.L.s.p+.......lssLs.QA................................................................................................	0	1	1	1
+1425	PF03524	CagX	cagX; 	Conjugal transfer protein	Bateman A	anon	PRINTS & Pfam-B_5812 (Release 7.5)	Family	This family includes type IV secretion system CagX conjugation protein. Other members of this family are involved in conjugal transfer to plant cells of T-DNA.	25.20	25.20	25.50	26.70	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.32	0.70	-5.06	150	1580	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	797	15	335	1390	79	205.60	22	75.21	CHANGED	Ds+l..........phhsYssspl.hplhsssGhsosIthpssEpl....ts...luhGD................ossWplss.............ptsplhlK..............................Ppp..ss.hsTNlslsTs+.....RoYthcLpup.spshh............................htVpFpY..Pp...............t......ttttttttsssshtss....hphss.................hNap.Yshp...Gsps..hpPhp.laDDGphTalpFsss.hp....hPslFhlss...pG.....p.cplVNh+lps........shllVcplhpp.hhLRhG....pp.sVsIhp..s	..........................................................................................................h.Ys.sthhplhst.shho.l.ht.sEp.l.............s.....lshGs.......sht..Wplts........................tsstlhlK..............................P..hp....s..hp.TN.lhl.hTs+...........RsYphpLtstptp..h.......................................htlpap...Y..Pp.............................t...tt.tt.t.t...t.p....t..sp..p..tt....h.p...tp....................................................hsap..Y.hp................ustt....htP..p.......saDD..G..phTahpFstt.ht.....hPslahlss......u............p.pphlN.h.phps...........shh.llcplhtp.hhL+hG.....pp.hltlhp.s...............................................................................................................................	0	62	186	252
+1426	PF03185	CaKB		Calcium-activated potassium channel, beta subunit	Mifsud W	anon	Pfam-B_2176 (release 6.5)	Family	\N	25.00	25.00	25.10	26.30	23.70	24.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.46	0.71	-4.94	10	225	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	48	1	119	207	0	174.90	38	79.42	CHANGED	tK.+lsou.psGEDRAlhLGLuMlssSVlMaFlLGhTlLpsYhpSlhs-EusCsVLpssIt--.hpCsaoCGs-CcssSpYPCLQVaVNLosSGppuLLaasEEslcpNsK......C.YlP+CpcDppchpsplpslp-pF+cp...QsFsCaasPspppssVLLpRhYsppsLhHsLhWPolhLsGGsLIVlhVKLTQaLSlLsEch	....................................+hs.t.ptGEsRAlhLG..lsMh.ss....ulhhhFll.GhTlLpsa..h..p....S..l...s.pEupCol.lpsplh-p.......hpCsasCGs-Cpthu........pYPCLQV...aV......N.l..o....p...SG......p...p..s..lLa....asE.-sh......p......h.N..c..................CS..YlP.t...........Ct..c.shpcsh...spV.slpp..accp...psFsCahsspt..p..csVlLp+hYst.slhHslhWPsh.hh.h..sGslIlshshhsp.Lulhstt.......................................................................	0	26	31	56
+1427	PF00214	Calc_CGRP_IAPP		Calcitonin / CGRP / IAPP family	Finn RD	anon	Prosite	Family	\N	21.60	21.60	21.60	21.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.80	0.71	-4.11	13	313	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	68	21	149	310	0	106.10	29	83.67	CHANGED	MsllphSshLss.lhsL..............pphsthpAsPhRpsL-shss..ss....cst.h.thlh.p.hp.php..ptppppt.....ttsts.......ucKRuCshuTCssp+LAchLsphss.hpsshuPss.luspuaG.RRRRul	...................................................................................................................h.........hh...................................t..h...................t....t......h.thh..t.........p..t.........tt..t...........t.ppp............hpKRsCshuTCssp+LuphLt+....s.s...t...pshsPTs.lGspua.G.++Rp........................	0	9	21	58
+1428	PF04847	Calcipressin		Calcipressin	Mifsud W	anon	Pfam-B_4547 (release 7.6)	Family	Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.31	0.71	-4.71	9	405	2012-10-02 20:46:34	2003-04-07 12:59:11	7	4	237	1	233	376	0	174.90	37	76.73	CHANGED	.pVFsssps+.........pphcsLapphscslpaphl+SF+RlhlsFss.psAtsA+hphc............t.phpG+p......l+haFu..Qs.ss..sssspaLtPPpssKpFLISPPuSPPsGW-..tp-ssP...ll...saDLhtALupLs....................................................tEchpl+sss.-ssPulll.....+sspst.pttt..............tscschspTpRPsh	.....................................p..h.t.p.h.........pphcs..Lappa.s...c....h...oF.....phh.....KSF...+...R...lhlsFssspuAscARh....pL..+.................pp..ph.Gcc...............h+lYFu............Qs.s......................hs....p..pa......LtPP..p..s..sKQFLISPPuSPPlGWc.......tp-ssP....Vl...saDLlt.Al..u..+Lus.......................................................................................................uEp.hE....L+sss....-ssPollV........+sspsp..p.tpt.........................................htts.+..pl.h.pTtRP..h............................................................................................	0	60	98	163
+1429	PF02029	Caldesmon		Caldesmon	Mian N, Bateman A	anon	IPR000075	Family	\N	50.00	50.00	50.80	50.80	48.70	49.70	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-12.95	0.70	-6.07	10	234	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	39	0	77	177	0	296.00	32	83.25	CHANGED	DDDEEEAARERRRRARQERLRQKpEE-shGQVo-psEssuQNSVssE-sKsoo.po...t.tsDDEAALLERLARREERRQKRLQEALERQKEFDPTlTDuSlShsS.RRhtND.su-NppsEKEE+pEuRppRpElEETEsVoKScQ+NsacDsE-ccp--+.+EccEEEc.c.tohtpN...............................................................................................................................................................................................................................................................p.hc-phcK-KtsK.-hKphhDtK+Ghs-.KuQNG..EhhT.KLKpsENsFS.s..tt....st.scsA.psEAG++LEEL+RRRsEhEsEEFEKLKQKQQEAAlE..LEELKKKREERRKVLEEEEQ++KQEEA-RKsREEEEKRRhKEEIERRRAEAAEKRQKhPEDGlSE-KKPFKCFoPKGSSLKIEERAEFLNKSlQK.SGVKsoHpsAVVSKIDSRLEQYTsAIE.GTKuuKPsKPAASDLPVPAEGVRNIKSMWEKGNVFSoPuusGTPNKETAGLKVGVSSRINEWLTKTP-GsKSPAPKPS.DLRPGDVSuKRNLWEK	.......................................................................................................................................................................................................................................t.t...ttp.............t......p.c.p...p..tt........p.tp.p..t.............................p...t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...........t...................................................................ttt...t..........t..............................................so...h+l.-RsE.LN+ShpK....suh+.sp.s..lucIDphL-QYTpAht...ts+ts+..+.ss.-Lss...s..ltshKohaEtGps.....tsss.ss..K-............................................................................................	0	3	9	28
+1430	PF05042	Caleosin		Caleosin related protein	Moxon SJ	anon	Pfam-B_5163 (release 7.7)	Family	This family contains plant proteins related to caleosin. Caleosins contain calcium-binding domains and have an oleosin-like association with lipid  bodies. Caleosins are present at relatively low levels and are mainly bound to microsomal membrane fractions at the early stages of seed development. As the seeds mature, overall levels of caleosins increased dramatically and they were associated almost exclusively with storage lipid bodies [1]. This family is probably related to EF hands Pfam:PF00036.	20.60	20.60	20.60	21.10	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.04	0.71	-4.71	9	275	2012-10-02 16:17:27	2003-04-07 12:59:11	8	3	97	0	153	262	3	155.30	43	68.07	CHANGED	+-pcphSVLQQHVAFFDpscDGIlYPWETYpGhRulGhshlsShhhulhINluLSYsThPuhhPS.hFPIaI+NIH+AKHGSDSusYDsEGRFhPsNFEpIFSKaA+TtPDtLThtElapMhcuNRsshDhhGWluupsEWhLLYhLA+Dc-GhLpKEuVRtsFDGSLFEpltK	...........................tthosLQpHluFFDpspDGlIaPh-TapG.hRsl.......GhshhhShhsshhIphsh..Sh.T..h..s.......u.......h..h..............Ps.Ph.F..sIYlcNIH...+uKHGSDous.YD.sEGRFlPtpFEpIFuKa..A.+s.t.s.......-tLThtEl.hphhpu...pRp...shD.hG.W....h.....u...uhhEWthhYhL.s...pcc..-G.h..l..pK-slRthYDGSlF.hlt....................................	0	38	83	123
+1431	PF00915	Calici_coat		Calicivirus coat protein	Bateman A	anon	Pfam-B_202 (release 3.0)	Family	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.92	0.70	-5.50	11	9404	2012-10-04 01:49:40	2003-04-07 12:59:11	15	15	8145	108	0	7359	0	130.20	53	60.76	CHANGED	hhASsD........AssssDGsuuss.lsPEsss.ssshsh-PssuutsAsAsuGpss.lD...sWhts.aVpsshu..TlsPp...GclLaslpLGPcLNPYLuHLSpMYsGWuGuh-VRlhlAGsuhhAGKllhuslPP..ul-slossphshaPHVlhDsRpLEPV.hslPDVRNshaH.ss.sssTh+LVhMlYsPLhsssuus..sshsluspV.T+PSsDFsFhhLhPP..plEppopP...holPplohpphuN.Rasu.IsuhhlsPs..hshQ.pNt+hshDGphhG...hSssplsslcusls	.................................................................................................t................s.s.Du.s.uu.ss..L.V.PElN.........NEsMALEPVsGAulAAPlu....G.Qp....NlID....PWIpN..N.FVQAP..sG.E.FTV..SPRN......uPGEl.L.hsh.L.....GPc.....L.....N...........P.....Y....L.....u.....H.....L....up.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1432	PF01067	Calpain_III		Calpain large subunit, domain III	Finn RD, Bateman A	anon	Pfam-B_852 (release 3.0)	Domain	The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.03	0.71	-4.56	91	1670	2009-01-15 18:05:59	2003-04-07 12:59:11	17	64	274	9	868	1478	9	140.30	28	20.07	CHANGED	pW...phshhpGpW.h.....pGs...TAGGCpNa.t.........TFhpNP.............Qatl...............plp-s--p.t..........................sslll..........uLhQ..............KscRpp+p...........t.c.hs........IGFslacl..........t.plsppahhpp...tshspopsahNtREVspR.hpLsPGc..YlllPoTFcPspcu-F.hLRlFocptsptp	............................................................W.p.thhpGpW.h..........pGs.....oAG..G....C.p.N.h...t.................................TF...hpN.P.................................Qa..hl...............plpcssct.........................................slll..........uLh.Q................+s.p.+.p..tpp............................tt.phhs................IG.Ftlacs...................................t.ph..p.pp.h.hhtp.................tshspo.t.s.a..h...s...t..R....-..Vsp..c..hpL.....s...P.Gp......YllVPST....a.....cPpp.pu.cF.h..LRlaoct.....t...................................................................................	0	247	356	615
+1433	PF00748	Calpain_inhib		Calpain inhibitor	Bateman A	anon	Pfam-B_543 (release 2.1)	Family	This region is found multiple times in calpain inhibitor proteins.	20.80	20.80	21.00	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.84	0.71	-3.82	24	632	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	49	7	111	594	0	125.40	35	73.52	CHANGED	lDuLSpDFosut...........st.ssuptcppcschssssu-slpts..ssssspouuPs.sp..psp....h.-DAL-sLusSLGpRpsDP-..-sKshtDcVKEKu.KcE+p-KLGE+--TIPP-YR.Lh-scDK-GKPhhPcs..cc	.......................................................................................................................lDtLSpDFst........................t..sstthp..pp..t.....t...tshs.Esl.sts.......ssss.sp...ou.sP...sp..t..tsp................h..D.s.AL-sLusSL.G.p.+p.s.-.P-...-sps.ht-cVc..-Ku...KpEch-KLGE+--TIPP-YR.Lhssp.c..ccG+PhhP.....p................	0	4	12	40
+1434	PF00402	Calponin	calponin; 	Calponin family repeat	Finn RD	anon	Prosite	Repeat	\N	21.10	21.10	21.30	21.20	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.67	0.72	-6.68	0.72	-4.59	5	1168	2009-01-15 18:05:59	2003-04-07 12:59:11	13	17	129	0	595	1070	0	25.20	59	20.32	CHANGED	luLQMGTNKaASQpGMTuaGtsRall	.....IuLQ..MGT..N..K.sASQuGMTu...aGssRpl.........	0	145	202	400
+1435	PF00262	Calreticulin	calreticulin; 	Calreticulin family	Finn RD	anon	Prosite	Family	\N	19.60	19.60	20.60	20.10	18.70	19.00	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.66	0.70	-5.82	68	1064	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	414	14	509	1004	21	294.80	45	68.78	CHANGED	saFhEpF.ts......thpp+Wl.Sptptpt.......t....hGcaplpsu.thhsshptD+GLhhppcA+aaAISs+..hspPhssc.s..................................KsLVlQYpVKhp.psl-CGGuYlKLhssshctp.....p..hs....scT..sYpIMFGPDhCG.ssK.lHhIh.........shhtcpalhptsh.p.....ssph.THLYTLIl+PcN.oaElhIDscpspsG.sLhcD.....ac..h.PPKcIcDPp-cKPcDW-DcthIsDP.cspKPEDWD......................c.PchIPDP-ApKP-DWD....--hDG-WcsPhIsNP.....................cYKGcWps.hIcNPsYKGhWtPpcIsNP-YhpD..p.h.h...s.lsulGh-LWpspushlFDNlll	..............................................hF.EpFpps........hp.scWl.Sptcpp.................Gpaphpts...h..ss..httD..........+..GL.hppcA+aaAlSuc..h..s.sassc..s..................................+sLVlQapV+ap..psl-CGGuYlKLhssshs.p......p..hp....scoP.YtIM.....F........GPDhCG.ssK..lHhIh...............shhtcpHh..h..p...shtt.....hsDph.THLYTL..IlpPDs.oaplhlDspthpsG..s.L.pD.....as...h..PP+...cIcDP...pspKP-..DWD.-.+tpIsDP.pshKP-...DWD.................................p..P..chIsDP-ApK.......P-DWD....--.DG-WcsPhIsNP......................pYK.GpWcs..IcNPsY+GhWh..cIsNP-ahtD...p.h..hh..pshsslGh-lWp......h...pushlFDNhlI.........................................	0	167	255	377
+1436	PF01216	Calsequestrin		Calsequestrin	Finn RD, Bateman A	anon	Prosite	Family	\N	19.70	19.70	19.70	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.37	0.70	-5.69	3	208	2012-10-03 14:45:55	2003-04-07 12:59:11	12	5	67	13	84	623	10	299.80	55	93.70	CHANGED	KsPaLhLAuLhLLlu...p.GsRGEEGLDFPEYDGcDRVIslotKNYKsVLKKYEVLALLYHEPluDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLDEEDSlYVFKGDEsIEYDGEFSADTLVEFLLDVLEDPVElI-Gc+ELQAFENIEDEIKLIGYFKSEDSEHYKAFEDAAEEFHPYIPFFATFDuKVAKKLTLKLNEIDFYEPFMDEPITIPDKPNSEEEIV-FV+EH+RPTLRKLRPESMYETWEDDLNGIHIVAFAEEuDPDGYEFLEILKpVAcDNTDNPDLSIIWIDPDDFPLLVPYWEKTFcIDLS+PQIGVVNVTDADSVWMEMDDEEDLPTAEELEDWIEDVLEGEINTEDDDDDDDD	......................................................................h...........hh.........s.u-c...GLp.....a..P...pYDG..hDRVhs.l.stKNaKp.sh.K.+.a.c.h.h.sl.hY.Hp.s.....ss.+s.Q+Qap......h.pEhhL.EL...........s.AQVh......E.....c.....+.....s..lG....Fsh..V....Ds..p..K.-..s..t..lAKK..LG.hpE..sSlYl..hK..t...-..c...h...I...E.aD.Gp.....h..uADsLVEFLhDl.l.E.D.P.V..El.I.p..sphElp.uF.-p..h..E..-..c...I...+..L.l.G.aF...K.sc-..S..-.a...Y..+.....A.Fc-A.AEc..FpPa...I...FF.A.TF.-.pt.VA....K.+L..sL...K..h.N.E............l.....D..F......Y......E.P......F....M.......-...E...P....l..s...I.P...s.K..P......o..E.c.El.V.pFl..ccHp.RsTL...R+L....c.s..-..s..MaEsW...ED.D...h.s.GhHI.V...A..FA.E.ctDP..DG.a.E.F.L.EhLKpVApDNTc...N...P.-.LSIlW.IDPDDFPL..........LlsYWEKTFpIDL..t.PQIGVVNVoD.ADSlWh..-hs.....s.......--.DLP......os-ELE-WlEDVL.pGclss-D......DDpcp..p.................................................................................................................................................................................................	1	20	26	47
+1437	PF03160	Calx-beta		Calx-beta domain	Bateman A	anon	Bateman A	Domain	\N	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.19	0.72	-4.05	32	5074	2009-01-15 18:05:59	2003-04-07 12:59:11	9	429	918	46	2189	4984	1811	97.30	27	17.36	CHANGED	sslslh...D.sDts.hlsF-pspapl...EssGt.splpVsphu.GslppsVhVsapTtD.GT....Apu..GsDY..psspupLsFsss.pst.pplpls.l....lDD-lhEps.EpFhltLs	.........................................................................................t...p-.......s....hh..........a....p.t.....s...p........h.....p..s........tE.....s......s......G.....s.....l....p....l.s.V....h....R.......ps....G..........s....................s....s....s..........l..........h....V..s..a..........p...T....t......s......G..o......................A..p.s...........G.........s.........D..Y...............ps.s.........p...u..........s....l........s.....F...t.s......G....co................p.....p.......plpls...I.....................l-.D...s...h...h...Ets..Es.FhlpL......................................	1	821	1173	1655
+1438	PF01213	CAP_N	CAP; 	Adenylate cyclase associated (CAP) N terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	27.00	27.00	27.10	27.80	25.90	26.90	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.97	0.70	-5.14	6	489	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	282	4	291	479	4	263.70	35	60.01	CHANGED	hppLlcRLEpATuRLEuVs.......sshhRss..............GssssPou.....slAu........................sssslpAFcshhuphlutalclS+cluG-VtppuEhVcpAFpsp+slLpsAupsp+Psps..cLt-LLKPIsEpItcltshREcNRuSKhFNaLSAlSEuIshLGWVuVsPpPssaVpEMcDuApFYTNRlLKEaKcsD.cpV-WV+uYLslhs-LpAYIK-aHTTGLoWsKcG.susstoAhsussouusssP..........PPP....PPPPPP.ssshhppssEuspu.s.psuhuAlFApLNpGEuITpGLKKVocD.KTHKNPsLRspss.sso...PKs.hpsPsP	..........................................................................tllpRLEtsssRLEshs.................t....................................................s.........................ts...............................s...lp.sF.D.p.h..l.st.ls.palph...Spplu.u...V.......tp......p...........uphltpua.p.p+thLhhus.ptppPs.s.....thtplLp..Plsctlppltsh+.Ep.s.Rs..St.h.FN.H....LouluEulsuLuWls.......h...s......s....p......PssaVpEh.suApFYsNR..........VLK-aKc..p..D......pHV..-..Ws+uahpl.h.p.pLpsY....lK..paass.GlsWst.p.G...........h........t.........h...........s..............t...........s..s...s..s.....s...s..P.......................PPP.............Ps.P.PPP...s.ss...t..................t......s.t....t.........tsshu..AlFupl.N.p.G.ps.l.T.p.u.L++Vscs.hTH.KNP.sLRstss.s.stt....st................................................................	0	91	146	225
+1439	PF04451	Capsid_NCLDV	Capsid_Iridovir; 	Large eukaryotic DNA virus major capsid protein	Kerrison ND, Coggill P	anon	DOMO:DM04206; Iyer L	Family	This family includes the major capsid protein of iridoviruses, chlorella virus and Spodoptera ascovirus, which are all dsDNA viruses with no RNA stage. This is the most abundant structural protein and can account for up to 45% of virion protein [1].  In Chlorella virus PBCV-1 the major capsid protein is a glycoprotein [2]. The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, are referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV. The virions of different NCLDV have dramatically different structures. The major capsid proteins of iridoviruses and phycodnaviruses, both of which have icosahedral capsids surrounding an inner lipid membrane, showed a high level of sequence conservation. A more limited, but statistically significant sequence similarity was observed between these proteins and the major capsid protein (p72) of ASFV, which also has an icosahedral capsid. It was surprising, however, to find that all of these proteins shared a conserved domain with the poxvirus protein D13L, which is an integral virion component thought to form a scaffold for the formation of viral crescents and immature virion [3].	25.00	25.00	26.50	25.50	19.20	23.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.29	0.70	-5.33	37	809	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	193	9	0	474	1501	166.00	33	55.42	CHANGED	ssshsssp..las-YlaLDstERpthupss+-YLIEQlQhtsppsh.....sssssspplcls...FNHPsKhLhashp....................................s..stsshsshhss....................s.ss.ssshh............................................................................................................sslpsupLhhNupcRFsppsup.YFshVQP.apphsps.Pss.......................GlahYSFuL.sssshpPsGohNaSRlcsspLplshps......................tsshssspshp.lhlaAhNaNlLRltsGhuGl	.........................................................................................s..............................................................................................................................................................s...........................................u.Pshssshsshs.h...................................................................................................................shs.l.pslolhhcsh..s..h.lsp.h.ssc..ahoth.P.aaa..ussh.....ps......................sGhhhhoaAL..shpc.hpPSGphNhuRh..pp..hh..lshcss................................hs..shpp.hc.LlV.AsshNhh.....................................................................................................	0	0	0	0
+1440	PF05159	Capsule_synth		Capsule polysaccharide biosynthesis protein	Bateman A	anon	COG3562	Family	This family includes export proteins involved in capsule polysaccharide biosynthesis, such as KpsS Swiss:P42218 and LipB Swiss:P57038.	20.00	20.00	20.00	20.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.64	0.70	-4.92	23	1766	2012-10-03 16:42:29	2003-04-07 12:59:11	9	20	670	0	306	1577	451	256.20	23	64.77	CHANGED	-sllhaGsctshcthtth..........pppshshhplE-GFlR...ths.th..PholslDchGlhaDsspPsch-plLpp.................shhststhspspphhshlhppploKYs..................................hpht...p...sps+chlLlssQVhsDtulp.huss...shpshtplLpsstccsP.suplllKsHPtshutp+h............uhhsph.t.tctsplhscDsshhsLlcpsctVhTloSpsGhEALLpsKsVhs...hGtsaYusaGLTpDtphp.......ppptph........slt.Lhstshlpa...............shY	.......................................................................................................................................hhha.s..p...t...h............sp.t.h...th...hh.hhE-GalR......................P.....hsl....sh-...chG.l....hsus..h.....P...p....ch.c...hlpp.............................................h.st..t...h.t...h...shth..h.p.h.l..hp..tp.h.s+Yp..............................................................................................t...........t........th.ppchl.Lls..hQ........l......sDssl...p..htss...............thpth...hchl..p..s.....h.t...p...c..s..P....puh..............l.l.hK...H..P..t.s..h..ut.pch.................shh.s..p..........t...hptt...h.h.h..s.c.s..s..sh....s.L.lcp.sctVhTls.S.p.sGh-A.LlpG+sVhs...hGhsaYs..thG..LT...p....ct...h........t.......tpp.ph.....................ht..Lhtss..l.hshY......................................................................	0	70	165	239
+1441	PF00194	Carb_anhydrase	carb_anhydrase; 	Eukaryotic-type carbonic anhydrase	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.20	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.50	0.70	-5.41	14	3112	2009-01-15 18:05:59	2003-04-07 12:59:11	16	24	954	506	1486	2849	68	215.10	26	65.40	CHANGED	WGYscpsuspp........WsphaPlAs.....GpRQSPIsIpopcspaDPSLKPLslSYssuoup..plhNsGHohpVpF-Dops+oVlpGGPLs.us.YRLhQFHFHWG..uscppGSEHTVDGh+YsuELHLVHWN..sKYssasEAhspsDGLAVlGlFlKlG..stpstlQ+llDsLssI+pKGppsshssFDPssLLPs...shDYWTY.GSLTTPPLpEsVTWlVhKEPIslSspQltpFRsLLhsscs-pth......hhsNaRPsQPL+sRsV+ASF	...............................................................................................................................................W.........t.............s.........s.t.......G.pp...QSPI...s...l......p...p.p..t...h.............h.......s.....s.........p........h.................t..s..l...p..h.....p..h.............t....t.....pl..h..N.s..G.+..o......l........p......l...p...h.................p......s.................................................h............l......pG..s........h......t..p.....a..............p.............htp.....hH.a.Hh................................sS.EHpl.....s.G....p...p..a..shE...h..H...l....V..Hh................s........................................................p...s...s....s....l......u...V.lu.l......h...h......p......h.u..........p....p.....s.....s...................h....p....t..l...h....p..t....l......t....t....l......t................t.............s.............p......p...s.............h.....t....s.......h.....s....h...p.......p.L..l..Pp.........ptp..Y.....ap.YpGSLTTP.......P...Cs..E.s.VtWh...lh.p.p.s.lp......l.op...........p................Q..............l........t..t.h................p.p......hh.........................................................t.N.Rs...Q..httR.l................................................................................................	1	360	612	1041
+1442	PF02977	CarbpepA_inh		Carboxypeptidase A inhibitor	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.50	21.50	43.10	42.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.80	0.72	-4.38	7	15	2012-10-01 19:46:11	2003-04-07 12:59:11	10	1	5	4	0	18	0	45.30	45	51.05	CHANGED	spshlssCNc.CsopuDC.GhThC.........ta...C.+hppossGhshpthulhs	...oNsLGTCNcYCsTNuDChGlTLC.........sW...C.Kh+KosuGhshupCulhP...	0	0	0	0
+1443	PF00619	CARD		Caspase recruitment domain	Ponting C, Schultz J, Bork P	anon	SMART	Domain	Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (Pfam:PF00531) domain-like fold .	23.90	23.90	23.90	23.90	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.56	0.72	-4.15	60	1660	2012-10-01 21:41:45	2003-04-07 12:59:11	16	127	129	33	789	1599	1	84.60	21	14.74	CHANGED	pphlcppRhtLlpplt...lst...lLDtLhpcpVLspc-h-plpp...pso...pts+.sRp..Llch.l.p+GsputphFlpsLpc..tpstLsphlptp	........................................phlcppRhtLlpplp.......lpt...ll..D.tLhp.pp......lls.pp-h-plps.....pso....ptp+.scp........Ll.-h.l..p.+G...p....p.u....hphF.lpsLpc....tpstLhp.l...t..................	0	218	269	437
+1444	PF01623	Carla_C4		Carlavirus putative nucleic acid binding protein	Bashton M, Bateman A	anon	Pfam-B_808 (release 4.1)	Family	This family of carlavirus nucleic acid binding proteins includes a motif for a potential C-4 type zinc finger this has four highly conserved cysteine residues and is a conserved feature of the carlaviruses 3' terminal ORF [1]. These proteins may function as viral transcriptional regulators. The carlavirus family includes garlic latent virus and potato virus S and M, these viruses are positive strand, ssRNA with no DNA stage.	20.70	20.70	21.00	20.80	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.42	0.72	-4.24	10	194	2012-10-01 20:03:16	2003-04-07 12:59:11	12	2	43	0	0	207	0	89.70	45	82.40	CHANGED	h+scslhplhcslacp.usshsh-lshsIlshsss+.lut..GRSpYARRRRA+SIGRChRCYRVaPP.hsFoo+CDN+TCsPGISaNh+VssFI	..........................................hhhhllhthh.ch.sshhshclC.VsIhp.hsucsVut...GRSoYAR+RRA.tsIGRChRC.YRVaPP..hpso+CDN+TChPGIShNh+VtsaI.........................	0	0	0	0
+1446	PF00997	Casein_kappa	casein_kappa; 	Kappa casein	Bateman A	anon	Pfam-B_1298 (release 3.0)	Family	Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.	25.00	25.00	32.80	32.70	19.00	17.90	hmmbuild  --amino -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.93	0.71	-4.53	9	256	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	142	0	12	240	0	137.40	73	97.48	CHANGED	ElQNQEQssCpEp-ERlFcpcpVhYlPlhaVLNpaPpYtssYYQpRsuls.hNN.ahsaPYYs+PlllRspAQIPpWQshPNh..........sTssR+PtPHPSFlAIPPKKhQDKTsIPsINTIAslEPTP..lPTs......EPsVNoVssPEASSE.I..STPETTTVsVTSsss	.........................h.p+hs.YlPh.YVLspYPpYGLNYYQQRPVAL.INNQFLPYPYYAKP.lAVRSPAQhLQWQVLPNTVPAKSCQsQPTTMARHPHPHLSFMAIPPKKsQDKTEIPsINTIASsEPTs..TPTT......EAlVNT..Vss.....EASSEsI.tSsPETNTsQVTSTtV.....	0	1	1	1
+1447	PF00363	Casein	caseins; 	Casein	Finn RD	anon	Prosite	Family	\N	21.80	21.80	22.60	23.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.74	0.72	-3.35	15	200	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	83	0	28	249	0	76.40	34	45.23	CHANGED	QlspLpphpp.phtls.spt....tp....hp...to..h..cpshholsQ...pphlphhpplhpa.p....hshhlpslhQYpcshh.Phsphts	...............................................................Q..pLsshps.pLsLs....hhps.......hcQ.....psh..o..hhs.pshholsQ.....+hLsh.ppls.a.Q....tsh.lQsh..h.........................	0	1	1	1
+1448	PF00302	CAT		Chloramphenicol acetyltransferase	Finn RD	anon	Prosite	Domain	\N	23.50	23.50	24.20	24.30	22.90	23.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.40	0.71	-4.70	12	768	2012-10-02 12:01:53	2003-04-07 12:59:11	13	6	590	61	135	572	473	191.50	33	93.28	CHANGED	MsFshIDlssWsRKEaF-HYhs.spCTYShTsplDITshhtplKcpuhKhYPshIYhluplVNpapEFRhuhsss.-LuhWDphpPsYTlFHc-TETFSulWo.acsDFspFhpsY.sDltpYucshphFPKsshPENtFslSulPWloFouFNLNltssssYLhPIFThGKYhpcssKlllPlulQVHHAVCDGaHsuRFlNElQ	.......................phlDhpsWpR+caFpaahp..ps.tauhTsplDlTt...hh...pt...hKpp.....shpFasshla.hls+shNp........htEFRhth.psp.plshaDplpP..sa.T.lh.p.pc.s.c..oFSslas...p.aps..DappF...hp...th.p...p-h.p.p.......htp.s...p...s.h......h.s.c..t...h....p.....N....h.h..l...SslPWlsFouhs...h.sh.s.s..sss..hh.h.Pl.hThGKah.p.c.s.s+lh.hPlulQlHHulsDGaHlupFhpclQ........................	1	52	92	122
+1449	PF03123	CAT_RBD		CAT RNA binding domain	Bateman A, Declerck N	anon	P39805/1-60 Psi-blast	Domain	This RNA binding domain is found at the amino terminus of transcriptional antitermination proteins such as BglG, SacY and LicT. These proteins control the expression of sugar metabolising operons in Gram+ and Gram- bacteria. This domain has been called the CAT (Co-AntiTerminator) domain. It binds as a dimer [1] to short Ribonucleotidic Anti-Terminator (RAT) hairpin, each monomer interacting symmetrically with both strands of the RAT hairpin [4]. In the full-length protein, CAT is followed by two phosphorylatable PTS regulation domains (Pfam:PF00874) that modulate the RNA binding activity of CAT. Upon activation, the dimeric proteins bind to RAT targets in the nascent mRNA, thereby preventing abortive dissociation of the RNA polymerase from the DNA template [2].	25.00	25.00	25.60	25.30	24.10	24.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.90	0.72	-4.28	15	2777	2009-09-11 00:54:21	2003-04-07 12:59:11	10	4	1579	7	291	1469	8	57.80	36	21.19	CHANGED	M+IcKlLNNNslllp.pcpppEtllhGpGIuFpKKtGDhlss.stIEKhFhLcscc.cpp+a	............hhIpKlLNNNVVl.sp....s..........cp.spE.h.llhG+..GIuF..p..KKhG-h.l..sp...p..p..I..EK.hFh.lcscp..tt......................	0	79	152	209
+1450	PF00199	Catalase	catalase; 	Catalase	Finn RD	anon	Prosite	Domain	\N	19.60	19.60	19.80	19.60	19.20	19.40	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-11.94	0.70	-5.78	121	5600	2009-01-15 18:05:59	2003-04-07 12:59:11	14	27	3265	302	1509	4794	143	346.50	44	69.89	CHANGED	TsstGssls.sspsohss....Gs...p.G.PhLLpDhpLl-cls+FsR.ERIPERsVHAKGsGAaGpFpso.s-.....hophTpAshhppsGp....cTPlhsRFSTVuGppGSsDss..RDsRGFAlKFYTc-GN.aDlVGNNhPV.FFlRDshKFPchl..HutK.pPposh....pcssth........................aDFhutpPEuh.Htlthlhoc.+GhP..toaRphsGaGsHTaphlN.spGctt...aVKaHacsppGhcslsscEAtp.htupssDatpcDLapsI.cpGsaPpWplhlQlhs.p-spph....p.as.hDsTKlWPcpchPl.......hplGphsLN.+NPsN.aFu-sEQsAFsPusl.VP.......GIphSsD.hLQuR.hFuYsDop+aRLG.sNa.plPlNt.P.......hs...h.s......pDG.hth............t.......ss..tssY.Psshssst	..............................................................................................................................................................................TpstGh.ls..s.s..psohps..........G....cG..PhLlpDhhhhEc...........ls+F.......s+..E+IPE..R..hVH.A+G.u.G.A.a..GhFpsp..ps.........l..o.chTp.....Aphhpp..Gc..............pTPlhlRF.S.TV...............sGpp.....G.....os..Dsh...RDs.RGFA.......lKF..............Y...........T............-..E....G...........N...a...........DLVGNNh.................P.l.FFl+Dsh...KF................P...Dhl..................Hu....K..pPcspl......pststh..............................WD.....F...ho..h..p...PEuh....Ht.....lhh...lhS...D....RGlP........toa....R.p.M.pGa.G..s..HT..aphl.....N.....s........p................G.cth......aV.KF.Ha............+..................s.......p.p........G....l..........c...s.....L...s..............-..........EAt.........c..........l.............t...........u......p.D...-.....atp+DLapAI....c...p.....G.s.aP.c.WplhlQlhs..c..-t..p..ph......p..as..s.hD..hT..K..lWP....cc...phP.l....................h.VGchs.....L......N....RN....P....c....N...aFu....E....s....E....Q....s....AF.......sP...upl...VP.......G.lp.hSsD....hL.......Q.uR.lFuYsDspt.hRLG..sNa..plPlNp.P.....................tss...hts.p...+DG.hph.......t........ts.....tssY.Psphs...t.............................................................................................................................................................	0	417	840	1230
+1451	PF00666	Cathelicidins		Cathelicidin	Bateman A	anon	Pfam-B_276 (release 2.1)	Family	A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.	20.70	20.70	20.80	20.70	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.15	0.72	-3.82	8	193	2012-10-01 19:28:07	2003-04-07 12:59:11	12	2	56	5	87	189	1	65.00	50	41.10	CHANGED	sLSYREAVLRAVDphNEpSSEANLYRLLELDPs.PpsDpDPsTPKPVSFRVKETVCPRTopQsPEQCD	............LSYcEAVlR.....AVDphNp+Ss-.sNLYRLL..-L.D.......P...P.............ptD.tcssos.KPVSFTVK....ETVCP+o...s.p..ps..sE..pCD................	0	1	1	18
+1452	PF04731	Caudal_act		Caudal like protein activation region	Kerrison ND	anon	DOMO:DM04892;	Family	This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family.  This region is thought to mediate transcription activation.  The level of activation caused by mouse Cdx2  (Swiss:P43241) is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway [1].  Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (Pfam:PF00046).	22.40	22.40	22.40	25.60	21.60	22.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.21	0.71	-3.88	14	144	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	47	0	59	120	0	127.30	37	51.59	CHANGED	MY.PuslRps.GlN.............LssQNF.....Vuu.PQYsDYsuYHH..VPsh....Dsps.pPsuuWussYusP.REDW.ssYususussush.s.......SP.uphua.sss-Ysshps..............susGlL.........ssssuustthSPuup...R+ssYEWMRKolts....susup	.......................MY.Pus...lRps.uls.....................Lss.QN.a......sus.PQYsDasGYHH..hssh......-stt...tss....suWsusYusP.....REDW.ssYu.usssss.s..............os..u.hua.sss-asshts...............susGl.L..........ss.ssss.tt.SPss.p...R+s.apWMR+sstss.ss.t.........................................................................	0	3	8	22
+1453	PF00689	Cation_ATPase_C	Na_K_ATPase_C;	Cation transporting ATPase, C-terminus	Bateman A, Griffiths-Jones SR	anon	Pfam-B_137 (release 2.1)	Family	Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.20	0.71	-4.75	141	8688	2009-09-12 06:26:15	2003-04-07 12:59:11	16	115	3188	71	3253	7683	303	180.00	22	19.21	CHANGED	shPlsslQlLalNLlsDshs.uluLuh-ss.-...pslMp+..Pc.t.ppslhstthhhpl.hhhGhhhuhhslh...sahhshh.............................................h.......shs...........................................................upThsFssllhsplhp.shssRo.....tt..............shht.hshh..pN..hh.....lhhuhhhsl.hltlhlhah..P.........lpph.F.pss....sl.......................shtpW.........hhs.....lshuhhhhhh..sElh....Khl	.............................................................................................................PLtslQlLal........NLlhDs.hsulALuh.....-..s...s.....-.................pc.lM..p..+....P....R...t.p.p.......s....l.......h......st.t....h.....htph...lhh..G..hh..u......hhs.hh...........s.a.h...hhhh......................................................................................................................................hh............shs...............................................................................................................spThhFss...h.lhs.Q...hhp..sh.ssRo..........pp...........................................shh.........hshh..............pN...hh..............lhhulh.hs.....h..hlt............h.hlhah.....P..........................hs.ph..F..pht.....sL............................s.h.tpW.........hhs..lshuhhhhhl...splhKh...........................................................................................................................................................	0	1051	1898	2639
+1454	PF03310	Cauli_DNA-bind		Caulimovirus DNA-binding protein	Mifsud W	anon	Pfam-B_3746 (release 6.5)	Family	\N	21.00	21.00	21.00	22.90	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.59	0.71	-4.26	3	30	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	18	8	1	30	0	102.50	43	89.24	CHANGED	LAsItSEIcEllosQKohcu-IKAILE+lGSssP.pouLEoVAAKIIsDLTKcIc-CcCNKEIlEhLspp...DcQIIPoPcEc..tKtLuLsKYSYPNasVGNEELGSSGNPNALKWP.hctPps	..........hsph.KElu.cllos.Kshcs-IKAI...L-hluSps.s......p-sLEslAAKIlpD...lschIscC.CsKcll-tLtst......cppl...p.pct.......tpthshtK....YSaPNasVGNtpLGSStsPpALpWP.......s.....................	0	0	1	1
+1455	PF03233	Cauli_AT	Caulimo_AT; 	Aphid transmission protein	Bateman A	anon	Pfam-B_3118 (release 6.5)	Family	This protein is found in various caulimoviruses. It codes for an 18 kDa protein (PII), which is dispensable for infection but which is required for aphid transmission of the virus [2]. This protein interacts with the PIII protein [1].	21.10	21.10	21.20	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.14	0.71	-4.53	6	35	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	22	0	3	37	2	136.50	49	73.75	CHANGED	MS.shos.PHIYKK.-pllRLKPLs.lsSNsRpYhFSS..pKusIpuIhsHCNNLNpIVuRsaLtlsKl.SYFGLpKDsSEthSKsKsP..shFsshppIF+cGGsspcppsp.lcoLpEhpN......RItclpppsKcLs-p.l.scsLhKc.VKDhcEpLscIc-ulKsIIG	.......................MS..lTupPHlYKK.-pIl+LKPLs.lsSNsRpYhFuS..sKusIpsIlsHhNNLNpIlGRshLtlhKlsSYFGLp........KDsSE............SKSKsP..SVF.ssucsIFKsGGsDh.ssphc.plcsLhEhpN........+IcpL-pthppLspc.I.scs.hcp.lK-hccplppIc-tlKsIIG............	1	0	0	2
+1457	PF01693	Cauli_VI	Caulimo_VI;	Caulimovirus viroplasmin	Bashton M, Bateman A	anon	Pfam-B_1373 (release 4.1)	Family	This family consists of various caulimovirus viroplasmin proteins.  The viroplasmin protein is encoded by gene VI and is the main component of viral inclusion bodies or viroplasms [2]. Inclusions are the site of viral assembly, DNA synthesis and accumulation [2]. Two domains exist within gene VI corresponding approximately to the 5' third and middle third of gene VI, these influence systemic infection in a light-dependent manner [1].	19.90	19.90	19.90	20.00	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-7.98	0.72	-3.93	212	1222	2009-01-15 18:05:59	2003-04-07 12:59:11	11	36	808	7	520	1128	69	43.80	36	16.86	CHANGED	Ka..YuVtpG+p..s.........GlY.soW...s-scpp......VsGasuAp..aKuF.sohpEApta	.....................a..YuVt..pG+p..s............Gla..soW....s-Cppp........VpGasuAp......aKsF.sohpEApta......................	0	188	333	458
+1458	PF04771	CAV_VP3		Chicken anaemia virus VP-3 protein	Kerrison ND	anon	Pfam-B_2147 (release 7.6)	Family	This protein is found in the nucleus of infected cells and may act as a transcriptional regulator.  It induces apoptosis, and is also known as apoptin [SwissProt annotation for Swiss:P54094].	25.00	25.00	25.10	41.20	24.70	18.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.63	0.71	-4.14	7	93	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	0	0	63	0	108.30	94	99.84	CHANGED	MNALQEDTPPGPSTVFRPPTSSRPLETPHCREIRIGIAGITITLSLCGCANARAPTLRSATADNSESTGFKNVPDLRTDQPKPPSKKRSCDPSEYRVSELKESLITTTPSRPRTARRpIRL	.............MNALQEDTPPGPSTVFRPPTSSR.PLETPHCREIRIGIAGITITLSLCGCANARAPTLRSATADNSESTGFKNVPDLRTDQPKPP.SKKRSCDPSEYRVSELKESLITTTPSRPRTARRCIRL.............	0	0	0	0
+1459	PF01146	Caveolin		Caveolin	Finn RD, Bateman A	anon	Prosite	Family	All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localised and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumour suppression [1].	25.00	25.00	25.60	25.60	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.88	0.71	-4.62	21	305	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	100	0	153	266	0	143.40	45	85.68	CHANGED	sc-ph...........................sctps...h..........p-.cptthshssRDP+plNsc.lKlsFEDVIAEP.suoHSFDtVWhsSassFploKYhhYRlLosLLulPlAhlhGllFAlLSslHIWhVsPhl+ohLh.lsslpplWs.shcshhsPlFpuhG+hhSulplplpcp	...................................................s......p.pt...h.hDscpt.thshssRDP+plNsc.lKlsFEDVIAEP.puTHSFDslWpsSassFploKYahYRlLoslhuIPhAllaGIhFAhLSFlHIW......hVsPslKohLI.t...lpslpplashhlcsh..ssPLFpulG+hFSslplphp+.-......	0	40	53	98
+1460	PF02275	CBAH		Linear amide C-N hydrolases, choloylglycine hydrolase family	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_5806 (release 5.2)	Domain	This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides.  These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, Pfam:PF15508.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.94	0.70	-5.00	8	2070	2012-10-03 21:14:07	2003-04-07 12:59:11	13	9	1418	42	386	1606	83	285.70	24	86.92	CHANGED	CTulshcspcsphlaGRNMDas......hshsppVI...lhPRsaslsh.cp.ss.hss+h..............AhlG.MGshhtshP.lasDulNE+GLuhAGLYa..ssaspap+ssccspssIssh.lhpaVLsNsoSV-EVKctLpphslVs.....sl..slh.hs.sLHahlsDtSGEulVI.EssK-.uLcVa-s.phGVhTNsPsa.cWal..TNLspYpulp.p..pshhhschclssaupGhGtlGLPGDhTPusRFlRsuahKtsh.cspsEstulsshFcILuossh.+GsVls.psp.chTlYToshssspGpYYachY-s.plptlsL.ccsL..............Dss-.hoa	..................................................................................CTuls.h..s..t.......p..s....p.hhhGRohD.at...........h.s..h.ss..p.lh.........lh.P..+...s.....h...p....h....st........p....t......s......s......p..........h......p..t..ph..........................uh.lG...h..u..h..s...........h...t.........s.h.......h.........h....s..D.G....hNEcGLu..h..ut..hah...........ss..h..up.a..t..p...t............p...t.....s.....p......s.....ls.....shph.l....palLsphsoVpEsc.pt.l..p.....p...h..p..l..ls...............................th.......st..h......s..........h..s...s.l.....H.ahlsD.tsGcolll.E..h..ps....t..........l.p.l........a............-s...........ht..Vh..TN...sPs.a..s.hph..tNL..p.pYh.hp.........................t..s.........h......s.s...........h......p.........h.................s.....t..t...Gh.h...s....L.P.G.s.hosssRFlRss.......a.h............p.......ts.............h...s.............p.............s................s............s............p............p............pu.l....sphapllpsssh...P.......h.......G....h......s.........h.........s.....t...........p........s..........p.......................p.......h.......Thaposhshppth.h.Yhcshts.p.l.htlphpp..........................h..........................................................................................................	0	137	230	310
+1461	PF03914	CBF		CBF/Mak21 family	Wood V, Griffiths-Jones SR	anon	Pfam-B_3822 (release 7.2)	Family	\N	20.50	20.50	23.40	22.80	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.16	0.71	-4.79	111	959	2009-01-15 18:05:59	2003-04-07 12:59:11	12	15	309	0	670	933	15	173.80	25	23.17	CHANGED	hsl.uL.hlh.t.lhpp....p.....slc........h.......scFYppLYphL..ssp...........................lhpss.+.pp.................................................hlpLLpphL..pssphsh..pplsAFlKRLhpl.ul.ptsssshsuhlhhltpLhpp...aP.shpsll.pspp.................t..................t...........t......................................................................................sYss......cc.....c-Pphs.s.A.po...sLWElphL.ppHaHPsVsphAp	.......................................................................................sl.uL.hlh.....lhpp....p...................sl-h.......scFYppLYphL..ssp...................................hhpsp.+.tp........................................................................................hhlplLpthL.............pssp....hsh.........tRlsAFlKRLhpl.uL.......pt....s...s.ss.......hhu.hLhhlppLhpp......aP...phpsl..l..cppp.pt..........t......................................................t................................................................................................................................sY..ss.................ppc-Pphs...s..A.po.......sLWElp........hL.p....p.H.aHPsVsphA......................................................................................................................................................................	0	233	374	558
+1462	PF02312	CBF_beta		Core binding factor beta subunit	Mian N, Bateman A	anon	Pfam-B_12381 (release 5.2)	Family	Core binding factor (CBF) is a heterodimeric transcription  factor essential for genetic regulation of hematopoiesis and  osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold [1].	25.00	25.00	27.50	27.40	24.10	23.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.99	0.71	-4.64	8	133	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	83	10	77	145	0	147.10	52	84.21	CHANGED	MPRVVPDQ+SKFEoDELFR+LSR-SEl+YTGYRDRutEERpsRFpNuCR-G+uEloFVAoGTNLpLpF.ssps.htp..............cc.lDFD+EhGKVHlKS.FIhNGVCVpa+GWlDLcRLDGhGslEaDEcRAppEDulh+csl-ptppRhpEFE-cpRta+csppsphpt......u.sl	.............................MPRVVPDQ+uKFEs-EhFR+LSREsEl+YTGaR-RshEER.phR.F.NsCR-...Gcs...El.uFVAo..GTNLpL.F.ssp..htp..............cc.sDF-+EtG.KVaL+ushIhNGVCVha+GWlDLpRLDGhGCLEaDEcRAtpEDAhh..ppth...-p.hppRhREFE-ppRsa+pp.ps..pt....t.sss...............................	0	20	25	56
+1463	PF02045	CBFB_NFYA		CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B	Mian N, Bateman A	anon	IPR001289	Family	\N	20.10	20.10	20.10	20.40	18.70	19.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.13	0.72	-3.43	25	558	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	271	0	319	542	1	56.50	67	18.95	CHANGED	--PlYVNAKQY+uIlRRRpuRAKhEt...pp+...................l.s+sRKPYLHESRHpHAh+RsRGsGGRF	.......EpPlYVNAKQ........YHtIL+RRpuRAKLEt...ptK.............................................l..s.KsRK......PYLHESRHpHAM+RsRGsGGRF.....................................	1	91	179	258
+1464	PF00808	CBFD_NFYB_HMF	Archael_histone; Arch_histone; 	Histone-like transcription factor (CBF/NF-Y) and archaeal histone	Bateman A	anon	Pfam-B_1351 (Rel 2.1) & Pfam-B_3673 (Rel 7.5) & Pfam-B_2078 (Rel 8.0)	Domain	This family includes archaebacterial histones and histone like transcription factors from eukaryotes.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.82	0.72	-3.91	28	2710	2012-10-10 12:36:46	2003-04-07 12:59:11	18	35	501	23	1800	5141	81	64.60	30	31.69	CHANGED	tpLPlAslp+IhKps..sst+..lup-ApchlscslpEFlphlsscAs.-hspcppRKTlps-DlthAl	................................h..LPhAp.lp+....I....h....K.....p.....s..........s....ssp............l..up....-Ah.h...l...............s.c.....ss..p.FIphlo...pc.........At....p...hs..p......p..p..p....R....K.......T.l..pspDlhhAh.....................	0	538	1012	1477
+1465	PF01656	CbiA	CBIA;	CobQ/CobB/MinD/ParA nucleotide binding domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_782 (release 4.1)	Domain	This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA Swiss:P29946 and CbiP Swiss:Q05597 from  S.typhimurium [4], and CobQ Swiss:Q52686 from R. capsulatus [3]. These amidases catalyse amidations to various side chains of  hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis  of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many  plants and animals and is primarily produced by bacteria [4]. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family [6].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null --hand HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.18	0.71	-4.90	79	20629	2012-10-05 12:31:08	2003-04-07 12:59:11	18	135	4514	62	5745	39422	11955	208.60	17	65.21	CHANGED	lslsutKGGsGKTThussLsthLup..tGh+VhshDh.Dspssssthhh...............................t.............h...htpshtsh.....................................thhsh.hhhph...tthpt..h......................................hpthhpthhptt....aDhlllDsssulsph................hspslsssshlllshpsph..hu..ltuhtphhphhpph..............lhGlllN+ht.s..pthtp.hh.thh.h.hhh....hh.........thhscshtlsp	..............................................................................................................................................lslsstKGGV..GKTT....s.......s..........s.s....L....u.......t.......s.L...........u..............p........p............G..........h...........+............V........l...l.......l........D.....h.....D....s.....p....s....s..s...s...s..h.ht.h............................................................hh...................................................................................................................................................................................h.h.thp...................................................................h...l.p.p...h...l..p..p...hhptt.............aD..h....l..l..lD....s...s....s...u....l.s.th......................................................................................s.h.s.u....l...t.....s.....u......c..........h..........l.......l........l...s...h...p....sph.........hu............lp.u....h.....t..p....l.....h.....p....h...l...p...p.ht..................................h.h.h.s..l..l..h..s.h...h..t....t........pth..t..h......t.......h............................................................................................................................................................................................................................................................................................	0	1917	3836	4923
+1466	PF02570	CbiC		Precorrin-8X methylmutase	Bashton M, Bateman A	anon	COGs	Family	This is a family Precorrin-8X methylmutases also known as Precorrin  isomerase, CbiC/CobH,  EC:5.4.1.2.  This enzyme catalyses the reaction: Precorrin-8X <=> hydrogenobyrinate.  This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyses a methyl rearrangement  [1,2].	21.30	21.30	23.90	29.00	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.14	0.71	-4.89	155	1640	2009-09-11 02:55:36	2003-04-07 12:59:11	10	16	1546	15	459	1277	315	196.50	41	85.28	CHANGED	sIh.pcSFthIcpEhs.....p..thsstp..tpllpRhIHuouDh-hsc..hlpFos....s..............ulpuuhsAL.psGu..sIlsDspMVtsGIspttL.t......ssplhChls-sclsphApptGtTRosAulchhtp..c.........hsuullsIGNAPTALhcLl-hl..cp..sts+PALlIGhPVGFVuAsESKctLtt........slPhIslcGR+GGSslAuAslNALlphsp	...................tI.ccSFtlIcsEhs........p.....th..s.sp.p..ptllhRhIHssuDh-.hs..c..pltFos....s..............slpsutpAL.....ps.Gu..........sI.lsDspMltsGIs+ptLs.t.......s.....sclhChlsDscVschAc.......p.tGhTRSsAAl.-lhtp...c...........hssu.lh.sIGNAPTALa+Ll-hl..c..p....s..s.s..c.PAhllGhPVGFVGAAESKct.Ltps.................slPalsspGR+GGSslAAAhlNALhh.....................	0	144	309	396
+1467	PF01888	CbiD		CbiD	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process [1].	25.00	25.00	35.50	27.20	19.40	21.50	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.51	0.70	-5.42	6	1191	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	1139	1	338	1049	276	250.80	40	67.94	CHANGED	scph+pGYTTGosAoAAAhAAlhsLh.ucphcpVplpsPs.GhplplslEpsch.puppAhAslhK-uGs.DhDlTpGh.IhuEVphpsGp.-lhIpGGEGVGhVT+.Gl.V.hGEAAINssPR+hIccslpchls-...scGs.VsISlPcGEclApKThNs+LGIlGGISILGTTGIVpPhSscuacsSLs.plslAhApsac+llhssGspGp+aARchh.slsp-thlphuNFhGahl-cAtcpGsccIlLlGasGKLIKlAuG	..................................s...LRpGaTTGoCAsAAu+AA...hhhL....l....p.......t...p...............h..........c...p..Vp.ls..hP......p...G...........p.......lphs...l...........pp...........hph......p........s...............s..........t..........A......t...........A..ulhKDuGD.D.PDlT+GhhI..hu.....pV............p...............h...............................s.............s.........t..................s...........t.............l..............h................lpu..GpGVGpVT+...GLsls.l....G.csAINPsPRcMIp...p...s...l...p...c...h...h...s..t..........................stu....hpl..pIslPpGEclAp+ThNsRLGIlGGISILGTTGIVpP.h.Spp....Aa.hpSlpht...l..c..l..t.....p.A.p.G..h.....p.p..llhssGstuEchsp....p...........h.........h......s....l...........sp.psllphusFlGhhLc...t...st......c........h......s............hp......c......lhlsG.th.GKlsKlAuG.............................	0	118	232	295
+1468	PF01890	CbiG_C	CbiG; 	Cobalamin synthesis G C-terminus	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Members of this family are involved in cobalamin synthesis.  The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [1]. Within the cobalamin synthesis pathway CbiG catalyses the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B [2]. This family is the C-terminal region, and the mid- and N-termival parts are conserved independently in other families.	21.20	21.20	21.20	23.40	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.28	0.71	-3.86	204	1400	2009-01-15 18:05:59	2003-04-07 12:59:11	11	24	1369	5	399	1196	300	120.40	30	34.00	CHANGED	slslGlGCc+ss..shppltpslppsLtp.......tslshpslsslAol-hKt-Es...ulhphApphs..hPlphassppLpt.t....hsss.SphVhpph.Gss..uVAEu.AALhuu............ssup.........LlltKpthss..............sTlAlAp	............................................................t.lslGlGC++s.s..shppltphlppsLpp............t.sl...s.tu.lps...luolclKtsEs...ullplApphs..........lP.hphass-pLpphp..........................h.ssSsh.Vt.cpl.Gss..uV.uEsAAlhss.............................s.sup..............................................LlspKhttss...............sThAlu................................................................	0	127	262	337
+1469	PF02571	CbiJ		Precorrin-6x reductase CbiJ/CobK	Bashton M, Bateman A	anon	COGs	Family	This family consists of Precorrin-6x reductase EC:1.3.1.54. This enzyme catalyses the reaction: precorrin-6Y + NADP(+)  <=> precorrin-6X + NADPH.  CbiJ and CobK both catalyse the reduction of macocycle in the colbalmin biosynthesis pathway [1,2].	28.60	28.60	29.00	31.70	27.50	28.50	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.62	0.70	-5.05	90	1417	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	1368	0	341	1152	320	240.60	29	86.82	CHANGED	h+lLlLGGTsEAptLAptLssts..........lssshShAGRstp..Ps..sh.slRlGGFG.....GssGLssaL...cpptlshllDATHPFAuplSpNAspAspptGlPhltlcRPsWp.ts.......sDp.WhpVsshspAsphL..........h...s.pR.VFLslGRppLstF......tthsppphllRsl-ssps.....slsh.ssspllhsRGPFshp........sEpuLhcpapI-slVoKNSGGs.ustsKlpAARpLGlsVlhlcRP.slP.sstt....hsssscslsalt.ph	..........................plLlLGGTs-uptluptLstts.............lsssoshuuchtt.........st.....ss...tl.+sGsh.......shcsltpal.....cc.p...pl..c..hllDATHPaAsplSpsA.h........pA.................s...c...........ps.....s...........lPhlRhcRs...sh..t....t.............................scs..hhhVsshppAsphh..................ph.......s.pp...lhLTsGppsLsta.........thsppphlsRslssscs......plsh..stt..cllsh+GPF..oh-..............hptslhcp..h....phc...........slVoKsSGus.uhptKlpAAtchGl.sVlhlpRP...sls......s..t.ph.....hpshsphhphl..t....................	0	105	223	288
+1470	PF01891	CbiM		Cobalt uptake substrate-specific transmembrane region	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein [2]. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway [3]. The NikM protein is Pfam:PF10670.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.60	0.71	-4.72	154	1775	2012-10-03 02:46:00	2003-04-07 12:59:11	11	5	1495	0	550	1442	303	202.70	27	84.38	CHANGED	HIsDGhL.ssshssshhslusshlshuh.....++lcpp......t...lPh.........................lul.huAhhFssphlslPl..su..oosHhlGsuLhulllG.sasuhlshslsLllQAllFucGGlssLGsNshsMulsus.hsua.hhhp..................l.......hph.........................thhluuhl....u...uhlulhhuulhsultLuls.s..............................................shthshshhh.......hsalsl.ull.EGllTshllshlt..+hcPch	......................................HI.-GhLss.hshshh..s..h.s..hshlsh.ul.......h+lppp....hp....ppp.........hsh.........................hul......s..uA......hh...Flh..p..h...l..pl...Pss..sG.....ossHh....h..G....s..uLsull....hG..shssslh.hs...l..l.Llh.QA....L....L.h..u..c.G....G..l..s...s...LGs.Nshs..Mul.h.ushlua..hla+..h......lpch....................thphhlusFl......u....uhl..us.h.h.s.h.h....s....s....u...l...p.L.ulu..hs...t.........................................hshhthhsh.hh....hsplsl..uls.EGllTshlhshlt.pht...................................................................	0	185	372	476
+1471	PF02553	CbiN		Cobalt transport protein component CbiN	Bashton M, Bateman A	anon	COGs	Family	CbiN is part of the active cobalt transport system involved in  uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12).  It has been suggested that CbiN may function as the periplasmic binding protein component of the active cobalt transport  system [1].	25.00	25.00	32.70	32.30	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.61	0.72	-3.98	12	603	2009-09-12 00:29:08	2003-04-07 12:59:11	10	1	593	0	137	328	12	71.60	44	67.62	CHANGED	hpplllLlh.hhlhllsLll....h.hpcts.hG.uDspAEcsIpc.lsstYcPWFpPlaEPPSGElESLLFuLQAA	........h..phllllh..sl.h.lhllsLll.......h.....hh....s...c.sut..aGGoDspAEptIpp.l.s.spYcP...WFpP...l...a......E.....P.....s.....SGEIESLLFsLQu..	0	47	99	122
+1472	PF02361	CbiQ		Cobalt transport protein	Bashton M, Bateman A	anon	Pfam-B_673 (release 5.2)	Family	This family consists of various cobalt transport proteins Most of which are found in Cobalamin (Vitamin B12) biosynthesis operons.  In Salmonella the cbiN cbiQ (product CbiQ in this family) and cbiO are likely to form an active cobalt transport system [1].	21.40	21.40	21.50	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.53	0.70	-4.79	21	6688	2009-09-20 21:39:57	2003-04-07 12:59:11	11	12	2806	0	1371	4611	488	211.40	20	79.22	CHANGED	tsshlHclsschKLlhhhhhllhssls.shhsh.llhsllhhshhlsths......phhtphhhh.hlhhlhshlhlhh.................................th.sthlhssss.......................................................h.lhp.G..............................hhtulhlshRhhshlhshhh....LshTTsh.ElssulcclthPh.........lshhhhLuhRal.hlhcEhpplhpAppsRshph...p.shtpthpplshLlsshhlp.uhc+uEclshAMpuRGYss...tpsph	...............................................................................................t....hpplss.t.sK.l.h.h.h..h..h..h..h..h..h...h..h..h....s..........s...h...........h..h...h..h..h..h..h...h..h.h..h..h...h..h..h.h..s.th....................h..h.h...h..h.h..h..h....h...h..h...h..h.l..h..h..hh.hhhh...............................................................h....t..t..t...t..h..l...h..t..h.hh...........................................................................................................h....l..t.t.t.u........................................lhh.u......h..h.l...h.h.....R.h.h.s..h.....lh.hs.hl................hsh...TTss.sp.l.h.s....u.......l.p.p.l..h..hPh.............................................................cluhhlslslRalPhlhc-hppIt.pApcsR...Gh..ph..........t...t......s....h......h..........p....p......h.....+.......s...h...h..........l....l....h.PL...h.hp....uhc+u-plutAM-sRG..aps.........h................................................................................	2	510	954	1206
+1473	PF01903	CbiX		CbiX	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of CbiX is uncertain, however it is found in cobalamin biosynthesis operons and so may have a related function. Some CbiX proteins contain a striking histidine-rich region at their C-terminus, which suggests that it might be involved in metal chelation [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.11	0.72	-3.92	76	2846	2012-10-01 23:23:09	2003-04-07 12:59:11	12	22	1311	18	915	2680	601	103.40	22	64.24	CHANGED	HGS.+c.scuspshtphs.phltcths..h.V.phuFl-hsp.Pslppul....p.plhtt.....Gsccl.......lllPhhL.hsG.hHscpcI......sp.......lp.....phptphs........................thp..l..hhupsLGscstlhplltp	.................................................+Go.pc....sp....us...t..th....p....ph....s..p....tlt....p..........p.........h..........s.....h...................V..........c....h..........uF...l...........p........hsp....P...s...lppsl................p.ph.htp...............Gsp.c.l.......................lll..Ph.h.....L.hsG.hHh..c..c..cI.........st.......lp.........php.t.phs.............................................................h.p.h.thu...s.sL.....Gs..cstlhphl..t...............................................................	0	286	665	834
+1474	PF02262	Cbl_N		CBL proto-oncogene N-terminal domain 1	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3949 (release 5.2)	Domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.	25.00	25.00	25.10	25.80	20.10	24.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.68	0.71	-4.43	3	228	2009-09-10 23:26:51	2003-04-07 12:59:11	11	12	88	35	117	222	0	122.10	60	17.48	CHANGED	.suosDKKhLEKsWKLMDKVVKLCQsPKLNLKNSPPFILDILPDTYQHLRLIaS+NEDpMclLp-NEYF+VFlENLM+KCKQsIKLFKEGKE+MY-ENSc.RRNLTKLSLlFSHMLuELKAIFPsGlFtG	..............ssD++sl-KsWKLMDKVV+LCQsPKLsLKNSPPYILDlLPDTYQHLRhI......h.S.+Y........-.....s......+....h.....t.....t.....L....u....-.....NEYF+lal-NLh+KoKpsIpLF.....KEGK.E+MY..-EpSp.RRNLTKLSLIFSHMLAELKAIFPs..GhFpG....................	0	24	34	66
+1475	PF02761	Cbl_N2		CBL proto-oncogene N-terminus, EF hand-like domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3949 (release 5.2)	Domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.	20.00	20.00	20.30	20.80	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.00	0.72	-3.91	5	227	2009-01-15 18:05:59	2003-04-07 12:59:11	9	15	92	35	122	226	0	81.50	68	11.39	CHANGED	pFRlTKA-AcpFWRcpFGsRslVPWupFcotLspsHPlosG.hEAhALKoTIDLTCNDaISlFEFDVFTRLFQPWsTLLRNWQlLA	......................FRITKADAA-FWRctFG...c+....TI.VPWKhFRQsL+cVHsISSG...LEA.MALKSTIDLTCNDYISlFEFDIFTRLFQPWuoLLRNWphLA..............	0	28	39	74
+1476	PF02762	Cbl_N3		CBL proto-oncogene N-terminus, SH2-like domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3949 (release 5.2)	Domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.	25.00	25.00	39.70	38.00	20.10	18.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.87	0.72	-4.35	4	215	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	85	35	115	217	0	84.00	81	11.55	CHANGED	sHPGYhAFLTYDEVKtRLQ+hhcKPGSYIFRLSCTRLGQWAIGYVouDGpILQTIPpNKsLhQALl-Ga+EGFYLYPDG+spNPDL	........THPGYMAFLTYDEVKARLQK.a.hpKP..GSYIFRLSCTRLGQWAIGYVTuDGsILQTIPHNKPLFQALIDG.REGFYLaPDGRshNPDL..........	0	24	34	64
+1477	PF00734	CBM_1	CBD_fungal; CBD_1; 	Fungal cellulose binding domain	Bateman A	anon	Pfam-B_444 (release 2.1)	Domain	\N	20.60	20.60	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.57	0.72	-4.28	133	1334	2010-01-08 14:00:54	2003-04-07 12:59:11	13	104	175	6	936	1332	9	28.80	51	7.32	CHANGED	tau.QCGG...G..a.oGsTs..CsuGhsC..pthNsaY	......haG.QCGG..tG.......a..oGsTs...Cs.....u..G..h....o..C..ph.Ns.aY.........	0	387	592	830
+1478	PF02013	CBM_10	CBD_5; 	Cellulose or protein binding domain	Bateman A	anon	PSI-BLAST P10476/668-713	Domain	This domain is found in two distinct sets of proteins with different functions. Those found in aerobic bacteria bind cellulose (or other carbohydrates); but in anaerobic fungi they are protein binding domains, referred to as dockerin domains or docking domains. They are believed to be responsible for the assembly of a multiprotein cellulase/hemicellulase complex, similar to the cellulosome found in certain anaerobic bacteria.	21.00	21.00	22.00	23.20	19.50	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.07	0.72	-3.69	92	276	2010-01-08 15:14:06	2003-04-07 12:59:11	11	56	49	10	58	278	0	34.80	41	10.69	CHANGED	s..Chspthu..YsCCss...s.tlhasDssGsWGlENs.pWCul	.........C.sttpu..YPCCss...s..s.hsDssGsWGh..ENs..p.Csh..	0	16	54	58
+1479	PF03425	CBM_11		Carbohydrate binding domain (family 11)	Bateman A	anon	CAZY	Family	\N	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.16	0.71	-4.58	15	149	2012-10-03 19:46:52	2003-04-07 12:59:11	8	40	89	1	61	228	302	177.60	16	25.80	CHANGED	suhshhl-DFEss.s.s..hh.hWto.ssssspsuoplss.....stsscuhplphs..sstuuashpVsasl-cu.......Das......................pauGlsF.h.......K...Guu+plc....lEIsDss......cs-lalsslssspo.WpplpIsFsshsp......sGhstcssh...DLccltu.lsFpspussu....ssapIDslcLh....stspspssps	...........................................................................................s......lDc...F-.....sh.........s............s........h..h....ahs...s.s.pssthphp.ts................stssps.....hp.hphs....sstsshh...ssh...ths..hs.tt................................DWS..................................................shs.ul.pF.hl.........+ss..Guuppls.........l.....pl..p.sss..................t..c.hah......t..p..hss....sts..Wp.plpIPFsshst.....s..ss...st...st...s...h.....clspltt...hsh...h.hssstt...........sph..h..lDslphh..............s.....................................................................................	0	38	47	54
+1480	PF03426	CBM_15		Carbohydrate binding domain (family 15)	Bateman A	anon	CAZY	Domain	\N	20.30	20.30	20.30	292.50	20.20	17.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.03	0.71	-4.87	2	3	2012-10-03 19:46:52	2003-04-07 12:59:11	9	1	3	3	1	7	0	160.30	69	26.24	CHANGED	lplDMssGWRGNuoG...pSGlThsuDGVoFsA.GDslGAVhDhh+PhpLEDAlIsMVVNVSuEFKAStAsLQ.hsQlKts...GEWsChAusp.hTAspDhTloCTlsEsDcKFNQTthDVQVGlQAKGTPsGslTIKSVTlTLA.tA.............YSAN	IEVDMANGWRGNASGSTSHSGITYSADGVTFAALGDGVGAVFDIARPTTLEDAVIAMVVNVSAEFKASEANLQIFAQLKEDWSKGEWDCLAASSELTADTDLTLTCTIDEDDDKFNQTARDVQVGIQAKGTPAGTITIKSVTITLAQEAYSAN.............VDHLRD	0	1	1	1
+1481	PF03424	CBM_17_28	CBM_28;	Carbohydrate binding domain (family 17/28)	Bateman A	anon	CAZY	Domain	\N	25.00	25.00	37.00	31.20	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.32	0.71	-4.67	7	48	2012-10-03 19:46:52	2003-04-07 12:59:11	9	6	27	11	12	57	0	188.40	35	39.07	CHANGED	VWu.EELSlSGEYVRARIKGhpYpP......I-RT...caocslWD..FNDGTpQGFslNuDSP.hpslslENsN..sAL+IoGLNs..SNDlo..EGNaWANVR..lSADt...WupshsIhGApcLTMDVIscpPsTVuIAAIPQSsstsWANPsRulpVp..ssFhppcDtpYKAhLTITstDuPslpsIApcscssshsNIILFVGo-s...uDVI.LDNIpVo	................Ws.ppLohSGpYsRuRIhG..Yts............p......hsphlhs..FpDGT+QGashsu-Ss.spss..lTIcssN...u.phhuhcs..spshs...sshWAs...A.....l.t-h....pups..lhhs.hLs...-hhscushslslAh.P.o.huh..WApsscshpls..schsp...tp..c..sp.chhhhhsh.D.splpshth.ssDohLpNlllhlussp...ustlalDNl+h............................................................	0	5	11	11
+1482	PF03427	CBM_19		Carbohydrate binding domain (family 19)	Bateman A	anon	CAZY	Domain	\N	20.10	20.10	20.10	20.10	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.14	0.72	-4.19	2	39	2012-10-01 20:20:38	2003-04-07 12:59:11	8	5	31	0	26	42	0	63.00	34	12.39	CHANGED	hTTTuhsTAoSA.hsh.hAspSCSoQsphuCTusGpYslCsaGKWVsusCPsGslClsosp	.........................................t.......................................hsGp..ossopGphACou.sGp...aAlCs.aG.sW.VhtpCsu.GTsCh....s...	0	8	15	24
+1483	PF00553	CBM_2	CBD_1; CBD_2; 	Cellulose binding domain	Bateman A	anon	SCOP	Domain	Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	21.10	21.10	21.10	21.10	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.07	0.72	-10.63	0.72	-3.96	17	1472	2012-10-01 21:34:18	2003-04-07 12:59:11	14	210	411	18	667	1442	50	96.90	30	17.38	CHANGED	spssYslsspWssGFsAslslpNsuosslssWolsash.s.GpplTpuWNAslosoGsshososhuWNuolss.....GuossFGFpGotsGus..sss.slsGss.C	.........................pssasssssW....s..u.....G......a.s.u....p....lslsNsGs.s.sl....s.u.W.slsash...sss..pp....lo..ss.....W......s..u..s.....h.......o.....p....o.......G.....s...p.h...o.ss..s.....s..u..a.....Nu....s.lus.....G.u.o.s...o..h...GFp.u.s.t..s.u..s.........ss.............................................	1	261	536	651
+1484	PF00686	CBM_20	CBD_2; CBD_4; 	Starch binding domain	Bateman A	anon	Pfam-B_111 (release 2.1)	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.41	0.72	-4.38	101	1301	2012-10-02 20:10:03	2003-04-07 12:59:11	14	99	591	106	739	1353	50	93.70	23	15.09	CHANGED	plsV.sFps.ps.....sTshGpslallGslspLGsWss.spAlsLshst....ssshPhWps..sl.sLPs.Gs....shEYKal+.....t.ssss...sV.tWEu..u.sNRshosPsssssssss	........................l.pFpl..ph.....psthG......p.plhl.....sGs..hspLG....s...W.s..s.......p.p.AltLpht..................t..s.hWps.....sl...sl......ss...sp.................slc..YKalh.................h..sss.s......sh...hW.Es...s..sN...R.hthst.......sh..................................................	0	308	491	631
+1485	PF03370	CBM_21	PRS; 	Putative phosphatase regulatory subunit	Mifsud W	anon	Pfam-B_2433 (release 6.6)	Family	This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localises it to glycogen.  Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.	21.10	21.10	21.20	21.30	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.67	0.71	-4.10	75	714	2010-01-08 15:58:43	2003-04-07 12:59:11	8	10	243	8	460	671	6	108.30	31	22.53	CHANGED	phppp.VpL...Eshtls.......ppslhGsltVpNluF-KpVtlRaT..hDsWcohp-lsupYhs...shtthsh....D..........................pFpFplsLsshht..........................................tpplpFClpY..pss.u....ppaWDNN.supNYplp	................................................t..ttp.VpLEph.hp.........ppslhGslpVpN.luF-K....pVtlRhT..h.DsWcohp.-ls..u.pYhp............sss..shD...........................................pFsFplslssh.h...............................................................ttplcFslpY.......ps.s..u........ppaWDNNsGpNYpl...............................	0	122	198	331
+1486	PF03423	CBM_25		Carbohydrate binding domain (family 25)	Bateman A	anon	CAZY	Domain	\N	26.80	26.80	27.00	27.20	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.00	0.72	-3.90	30	440	2010-01-08 16:02:45	2003-04-07 12:59:11	8	47	133	10	176	429	14	84.90	26	18.88	CHANGED	usslclaYNhssssLstpsclah+GuaNsWsps.uhs.chsc...t......usahpssl.plPppAhhlDaVFssG....sssYDNNsspDaphsls	...........................................sslslaYs......t....p..ps.h..s.t.psp...l..........ah+s.u...a...s....s...W...s....ps.......u..hs.p....ttp.................ssahpss.l.plPtp.Ah.t.l-alFssG.....ussa...DN...Ns...sp...Daphsl.s.............	0	61	121	159
+1487	PF02839	CBM_5_12	CBD_7; CBM_5; 	Carbohydrate binding domain	Bateman A	anon	Bateman A	Family	This short domain is found in many different glycosyl hydrolase enzymes and is presumed to have a carbohydrate binding function. The domain has six aromatic groups that may be important for binding.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-7.97	0.72	-4.37	135	2927	2012-10-03 03:17:01	2003-04-07 12:59:11	9	197	1085	40	615	2508	403	42.20	30	7.84	CHANGED	hssWsss.ps..Yss.G....-hVs.asG..phYpA.phasp.st...tsssst..........sW	...................ssWsus.ps...Yss.G......DpVs..a..p..G..psYpA..paWTp..us.........pPstss..........sW............................	0	203	349	497
+1488	PF04942	CC		CC domain	Bateman A	anon	Pfam-B_4563 (release 7.5)	Domain	This short domain contains four conserved cysteines that probably for two disulphide bonds. The domain is named after the characteristic CC motif.	20.60	20.60	20.70	20.60	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.04	0.72	-4.07	29	101	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	6	0	95	112	0	35.30	31	20.03	CHANGED	ssssshsCc..uss.....sPshs.GtCPsGhsllpushCCssc	..........tshsC+.......uss.....sPuls.GhCPsGhslltus.t.CCsp.t.....	1	41	43	95
+1489	PF01845	CcdB		CcdB protein	Bateman A	anon	[1]	Domain	\N	23.40	23.40	23.70	26.10	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.22	0.72	-4.09	12	537	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	413	26	75	272	31	98.20	43	98.60	CHANGED	hQFpVYpshucut...YPhllDVQSDlIsplsoRlVIPLhsscph.t.+ssp+LpPllp.l--psallhTppMASlPsslL.Gp.VsDLospRppI+sAlDFlhsGI	............MQFpVYps+tcsp...a.hhlDVQSDIIcshspRhVIPLsshchhsp...+ss..ccLhPllp.lsscsahlMTp-hAoVPlssl..Gcc..VsDlS.p.+cspIKsAlDhhhpGI..............	0	14	34	51
+1490	PF04995	CcmD		Heme exporter protein D (CcmD)	Bateman A	anon	COG3114	Family	The CcmD protein is part of a C-type cytochrome biogenesis operon [1].  The exact function of this protein is uncertain. It has been proposed that CcmC, CcmD and CcmE interact directly with each other, establishing a cytoplasm to periplasm haem delivery pathway for cytochrome c maturation [2]. This protein is found fused to CcmE in Swiss:P52224. These proteins contain a predicted transmembrane helix.	23.90	23.90	24.10	24.60	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.06	0.72	-4.23	96	1201	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1174	0	214	605	209	48.40	37	73.35	CHANGED	GsYuhYVWsuYulohlslshLlhholhpp+plhpclpctptRpt....ch	.....GGYAhaVWhAhuhTllsLslLllpolhp+RtlLptltp.ppAREs.R.h..................	0	45	106	160
+1491	PF03100	CcmE		CcmE	Mifsud W	anon	Pfam-B_2583 (release 6.4)	Family	CcmE is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor.	19.90	19.90	21.00	22.00	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.50	0.71	-4.58	135	1616	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	1542	4	402	1031	1646	131.90	46	83.52	CHANGED	h..st.+++RLhllshslsuluhAsuLlLhAhppslsaFaoPo-lhpscs........s.sspplRlGGhVppGSlpRs..suhpVp.FpV.TDs...s.........ss.lsVpYpGILPDLFREGQGlVApG................ph.tssG....sFtAsEVLAKHDEsYMPsE	...............................................................RR+pR..Lh.llhullsululssuLlLaAL.p.p.NIsh..F...YTPuEl.l.tGct..........t.sGpRlR.l.GG.M..Vh.....G.S......VpRss........soLc..Vs.Fsl.......t....Ds....t.........................s.s..V..sVsYcG..I..L.P.D.LFRE....GQGVVspG........................pL.tpss.....phhAcEVLAKHDE.sYhPPE..............	0	113	247	324
+1492	PF03918	CcmH		Cytochrome C biogenesis protein	Finn RD	anon	DOMO_DM01577	Family	Members of this family include NrfF, CcmH, CycL, Ccl2.	25.00	25.00	25.10	27.10	22.30	24.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.83	0.71	-5.21	177	2053	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1387	2	373	1270	1631	139.80	38	68.57	CHANGED	hlhhl..lhl..hh...................sh...sss.sDph.h...ss.....s.EpRhppLscpLRCsh.CQNpsIsDSsAslApDLRtpVh-hltpGcScppll-ahVsRYG-FVlacPshpstThlLWhuPhllLlh.GhhhlhhhhR++pttt..........................sLosp-p.....tcLppl.Lp	........................................................hhh...hh.lhL.hhs..................sut....tss.lDshpF..tss......tQcpphppLsppLRCPp..CQ.N..p..slsDS...N...A.l.AsD...hRppVYc.h.l.p.......EGKSc..pEIlcaMlsRYG.cFVpYsPP.....ls...st.TllLWhhPl......lhlllGuhll.h.tht.++pht...........................................t...........................................................................	0	93	206	291
+1493	PF03597	CcoS		Cytochrome oxidase maturation protein cbb3-type	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	23.00	23.00	23.40	23.40	22.50	22.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.99	0.72	-4.50	127	978	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	954	0	277	677	88	44.60	39	69.38	CHANGED	sllhlLIPlullluhlulhsFhWul+oGQaDDl-ssutRILhD.D-	................phlhhLIPlulllshlulssFlWul+oGQFDDl-t.uppI.LhD.D-.......	0	74	175	227
+1494	PF03150	CCP_MauG		Di-haem cytochrome c peroxidase	Mifsud W	anon	Pfam-B_3135 (release 6.5)	Family	This is a family of distinct cytochrome c peroxidases (CCPs) that contain two haem groups. Similar to other cytochrome c peroxidases, they reduce hydrogen peroxide to water using c-type haem as an oxidisable substrate. However, since they possess two, instead of one, haem prosthetic groups, bacterial CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two haem groups have significantly different redox potentials. The high potential (+320 mV) haem feeds electrons from electron shuttle proteins to the low potential (-330 mV) haem, where peroxide is reduced (indeed, the low potential site is known as the peroxidatic site) [1]. The CCP protein itself is structured into two domains, each containing one c-type haem group, with a calcium-binding site at the domain interface. This family also includes MauG proteins, whose similarity to di-haem CCP was previously recognised [2].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.45	0.71	-3.93	173	2309	2012-10-03 10:02:11	2003-04-07 12:59:11	9	22	1444	47	631	1895	669	159.60	36	39.95	CHANGED	sttp.spLG+tLFaDspLSts.......sslSCAoCHs.ss..........t..uhsD..stsh.......u.hG.....hs.s.................ph.......ssR..NuPolhN.suap...............................................h.FW.DGRs...............................s..s..L.cpQA......htPl..tsshEM......ut...s........................hppll.p+Lps.............st......YtphFppsFs....................................sps........lshpplspAlAsF.p+ol...hossStFDpal.....pG.-tsAl	...................................s..p+stLG+tLaaD...sR.LSts.......ss.lSCuoCHs..hs.............t..uhsD......shps........................o..hG.......hs.s........................................................................................ph........GshNuPTlhN.usash.......................................................................s.FW.DG.RA...............................................................s.sL.p-Q.A......tGPl..hsPhEM.............us.......s................................................hctll.t+lpp................................st.......YtptFppsas..................................................ps....hshc.s.l.scAIApFE+TL...lossS.FDcaL.cG.-ppAh..........................................................................................................................	0	223	417	541
+1495	PF04505	Dispanin	CD225;	Interferon-induced transmembrane protein	Mifsud W	anon	Pfam-B_2070 (release 7.5)	Family	This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression [1].	27.10	27.10	27.30	27.40	26.70	27.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.79	0.72	-4.44	68	837	2009-09-11 14:57:37	2003-04-07 12:59:11	7	11	210	0	406	837	11	81.30	26	49.85	CHANGED	ss.usssh...............spsaLshuIhsol....hCsh....P...lGllAllaSspspsthttGDhsGAppsuppA+thslhuhlh....Gllhh..llh.l	...............................................................spD.a.ls..hulhssl...........hChh.......P.......lGllAhhaS.h..........cspsthhtGDhpuA.pphuppA+hhs....lhulhl.Glhhhlhh.h..........................	0	97	146	220
+1496	PF01130	CD36		CD36 family	Finn RD, Bateman A	anon	Pfam-B_1229 (release 3.0)	Family	The CD36 family is thought to be a novel class of scavenger  receptors.  There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.	19.80	19.80	20.30	20.00	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.55	0.70	-6.19	52	1012	2009-01-15 18:05:59	2003-04-07 12:59:11	16	15	151	0	630	1015	58	355.90	22	82.78	CHANGED	hhsluhllhlhuhlhhhh.asshhpphlccplsLps...sop.......sac.Wtps........Phslhh.p.........lYlFNhTNs--hhs..ut+PplpElGPYsY+.EhtpKhslpassss...Tloa..ppp+sahFpP-...hSsG.....stsDhlsssNlshlussthhpp..........hs.hhp...............................................hhlshhlpt.....stphF.hspolt-hLa..........GacDsl..lshhpp.........h...............spFGhhhs..cNso...sshaslhTGtc.shpphGh..........lppasGpsph..sh...............Wps.........C.s.....plpGo.-GohFsP..h.lpp.pcslhh..Fts-l.CRslp...ltappsss.hpGIpsa+atss.spshsssptpspstCa................C.tstt...........................Ch.sGlhslosCh....G..uP....lhhShPHFa..tAD.phhpslp.Glp.Pst-cHp.halslcPhoGhPlp.sptRlQlNlhlppsps..h.shhps.hs.shlhPlhWhcpss.tlscphhshl.ptlhhh.plhthhthshlslGllhlhhhlhhhht	.................................................................................................................................................h...............................h.p.th.lt...ss.............hp..W..p.............sh.hhh..p..............hahashpNspchht....s..tp..lpphGPYsap....chh.+.sl.p......t..tp...s......plsa.....p.h.F..p..........hS.s.......p-.lhh.Nh...hhsh..h..htp.......................hhp..................................................................................................................................................................................hhhs.h.hp..........ttt.h..hp.....hss...t-hha..............Gaps..h......hphh........................................................th.u.hh.......hNso.......ss.hphhsGhp..sh....t.ph..s...........................................l..pa.p.s.p..ph......sh..............................ats................C.s................l.pG.o..suph.a.P........h...hp.....pp...l.h..a...........-h..C.....R...th......h.atpp........hp.G.l.s...h+ahhs..p.hs.s.s..t............st.sa................................................................C.......................................C...tGhhsls.C...........s......tP..................lhhShPHFh....us..........h..........h..p..t.l..p......G..........h....p....P.s.................cpHp...hhh.lpP...............h.....sGhshp.sth+hQhNhhlp..tt....................h....h.t....p.....h............t................hh...hPhhah.p...................th....h.s.tthhp.h.......h..h.......h......h.h...h...hh.h....hh.uhhhhhh...h....h........................................................................................................................	0	248	319	521
+1497	PF04549	CD47		CD47 transmembrane region	Mifsud W, Bateman A	anon	Pfam-B_2739 (release 7.5)	Family	This family represents the transmembrane region of CD47 leukocyte antigen [1-2].	25.00	25.00	26.70	27.80	21.20	23.00	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.25	0.71	-4.22	13	120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	61	0	25	104	0	151.00	44	53.06	CHANGED	hlIllhhhlhllLhWupls..hlohKh..sphc+hIhlhhssulllTlIslVGtalh.lssthshhphpGlsLI.lshhh.IhLphhla.htltho.phhIsllllQlluYlLollslsLslhsC.pslaG.LLI.sLhlIslhELhuLlhhhh...hsssp+shh	............hLlhIFshlsllLhWhphu..hhol+h.Ssshspph.hhLhVhGhllolIhlsGAhLF.hP.u.aol+phhGLhhhslsohhLIllphhsFhh..hhtho.shlhhIlhhQllGYILsVlGLuLslptC...VcGsLLlSGLuhIsluELhuLlahhh...hsSsQ+sh.............	0	1	1	4
+1498	PF03234	CDC37_N	Cdc37;CDC37; 	Cdc37 N terminal kinase binding	Bateman A, Wood V, Mistry J	anon	Pfam-B_3345 (release 6.5)	Domain	Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domain corresponds to the N terminal domain which binds predominantly to protein kinases [2] and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain Pfam:PF08565.  Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability.  This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function [2].	26.10	26.10	26.60	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.52	0.71	-3.95	21	361	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	238	0	221	333	1	125.20	28	34.41	CHANGED	slDYSKWD+IElSDDSDlEVHPNlDppSFIRW+QpsIHE+RppR+p-hcsLchphphsscLhpRlc+hLspLppp.t..s...........l.....t................................p........ppMh.sLh..l.....p.t.t..........sshhpplppHppKlcshpc-hppKLcELpKccpppIsS-Dl..HsGFspS	..............lDYSKWDtlElSDDpD.-sHPN...lDptShhRh+ppthhcchtp..hppchcplchpht...pthhtchpph.lpphp.p....t..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	68	108	175
+1499	PF02724	CDC45		CDC45-like protein	Mian N, Bateman A	anon	Pfam-B_1919 (release 5.5)	Family	CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae (Swiss:Q08032), forming a complex with MCM5/CDC46. Homologues of CDC45 have been identified in  human [1], mouse and smut fungus (Swiss:Q99107) among others. 	34.00	34.00	36.20	34.90	33.60	31.70	hmmbuild  -o /dev/null HMM SEED	622	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-12.88	0.70	-6.49	33	405	2009-09-10 22:41:12	2003-04-07 12:59:11	9	4	282	0	267	409	17	488.50	28	92.86	CHANGED	.VlllVuh.-lDALCAs+ILssLhKpDhl.apllPVtGYs-L.............cpthpch..spshpp...........llhlsCGuslDLtshLphs............................tshplaVhDuHRPasLsNlau....................................ssplhlhsDssh--phpt....cc...hapth........................cs-s-s-..s-s-s-sssp......pc.........t.ts.ppttcpc.hphcRp.p...................................................++pp++.hccpcphlpthYppushaupSsuhhlYsLA.plu+s..st.-hLWhAIlGlosh.l...................tthstppYsph.hthLpcEVpRLssps.....................tssspos............................sshpIsh.p.-h+LhLhRHWSLY-ShhaSsYluu.+LcLW.o-pGcK+L+cLLA.+MGlsLsps+QsataMDhplK+pLtphlc+.uspaGLpclsht...............uFs+saGa+.splSAuDsVhulsALL........Ess........................................................................................t.....tt.tppcpcphhssFapAhDALs................ppsh-lLppGlphAptLppAIhpsssoll.-p.c.lpshpsF+hsllp-.u...PDlclFspPhsLscLupaLlcuhspp...pcppttt..............hPLVlAu.LcpspsshlVl.Gl..........................................................................s.tpptp...................tNpFuhAFppsuppo.sA+lphDsF-sulIEl+p-DLssFL-sLohtss	............................................lhlh.ss..-sDulCAs+lL.p.tLhpp-.l...aplhPltuht-l.............pp.hh.ph...........p.hp..............hlhlssGu.lDl...p...h...L.t..t...................................tth.halhDs+RP.h.slsNlas......................................pttlhlh.c.tp.c.p.......cp...ha.t......................................................ttpptpp..pptt..t..t.tt...................t..............................................t.pc..................................................................................................................................................................................................ppp....hp.hpt...ct.l...Yp.hp.aups.u.hh..........ap.L..u..hs+p.......p..-...h...LWhullGlos..l............................thh.t.th.t...h..lppcVp...phs..p.....................................tp.hs.............................pp.p.lth..p.-..................phhL.hpHWoLa-Shh.osahss.phphW..s........p.................G...........tc+Lpphl....A.cMG.lsLtp..spQpat......Mshpl+cplhphh.c..h..ash..pphh.................sF.hpaGap.tph.AtDhshshhulh........Es...................................................................................................................ttttthhtpFhtAhDuLs.......................s.p.L.tul..hAp...pul..ppstshl..pp.p...lhp.t.....ahhs.l.....-..u............s-.ht.hFsp.P.hsL.hLu.alhcshh.p........tttt..................................hPllhus..h.......s..p.pshhhll.Gh..............................................................................................t........................hN.Fu.AFppsstps.ss...p.hhhs.F-.shlplptp-hs.FhptL.....h...................................................................................................................................................................................................................................................................................................................................	0	106	156	224
+1500	PF02933	CDC48_2	cdc48_2; 	Cell division protein 48 (CDC48), domain 2	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_799 (release 5.2)	Domain	This domain has a double psi-beta barrel fold and includes VCP-like  ATPase and N-ethylmaleimide sensitive fusion protein N-terminal  domains.  Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate  185-residue recognition domain [1].	22.40	22.40	22.40	22.60	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.88	0.72	-4.33	103	1049	2012-10-01 20:15:13	2003-04-07 12:59:11	12	16	512	49	687	1072	104	68.70	25	9.07	CHANGED	thsss.ht.hltpphts..pslstGphl..............hh...sh......h..................sptlphtVhsspPss.............sl.hlscsTplpl.t......pcssph	..............................................hsss.hshhlp..h.Fhp...+PlppG-hh..............................hl....ph.t...........................hpsl.pFp.....VspscPss..................hs.hls..sT.lphp.....tcs...t......................................	0	197	383	563
+1501	PF02359	CDC48_N	VAT-Nn; cdc48_N; 	Cell division protein 48 (CDC48), N-terminal domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_799 (release 5.2)	Domain	This domain has a double psi-beta barrel fold and includes VCP-like  ATPase and N-ethylmaleimide sensitive fusion protein N-terminal  domains.  Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate  185-residue recognition domain [1].	25.10	25.10	25.10	25.10	24.90	25.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.64	0.72	-4.04	120	1252	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	680	48	754	1224	114	82.90	27	11.30	CHANGED	pLpVscAh.pp....csspulsplsspshppLslptGDhlplpG.c+p.Ts.shVhsstsp....sp....tshIRhsshhRpNsslulGDpVpVcpsp.s	................LhVscs....p.......spul..ltlsssshppL.....t.l........h...pGD.s....l.hlpG..c+.......p..Ts.shVhsscsp.........st.....uplphst.....s.hRp.NhtV.p.lG..DhVsVp.ss..h...............	0	221	435	635
+1502	PF03381	CDC50	DUF284; 	LEM3 (ligand-effect modulator 3) family / CDC50 family	Mifsud W, Kerrison ND	anon	Pfam-B_2846 (release 6.6)	Family	Members of this family have been predicted to contain transmembrane helices. The family member LEM3 (Swiss:P42838) is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells [1]. The products of genes YNR048w (Swiss:P53740), YNL323w (Swiss:P42838) and YCR094w (Swiss:P25656) (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39 [2]. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure [4]. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway [3]. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants [2] may be due to inactivation of CDC39.  The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.	26.70	26.70	30.50	28.00	18.90	26.60	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.00	0.70	-5.23	76	747	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	312	0	511	720	9	276.90	32	77.38	CHANGED	l.....hhsupplp-lpl.cYsssstsss..................................................................sCplsFsls....pphcu.PlahYYpLsNFYQNHRRYVpShsppQLpGct.hs.sp.......tCcPhph........................pssc.hh...hPCGLIAsShFNDTash.....................sss..sssh....................shs.....ccG..IuWpoD..+pp+a+p..sph.p.t...........s.P.sW.t................................shp.ss.hPssp........pE-FhVWMRoAALPsFpKLat+h.......sssL.sGp.YplpIp.NY.....PVppFs.Gp..KpllloTsShhGG+N.FLGlsYlllGulshllulhh.llhahh.ps+.....phu-ts	...........................................................................h.hhsuppl.El.h.cYspsp..ss..........................p..............................................hCplpapl.s....p.ph.p....s.slahYYpLsN..FYQNHRR.Y..VpS.hs.spQLpGps..hshps..............psCpPhphs..................................................tssc...slhPCGhIAsShFN..D..Tash..................sssspth............................................shs.......ppG.IuW.o.D.+.t+Fpp.....sth.t.t...................................ths..Ps..sW..p.......................................................................................shp..ss..P.s.p............sE-ahVWMR...TAALPsF+KLYt+lt...................pssL.sGp.Ypls.I.p....s.a.............sVtpFs.Gp..KpllloTt.o.hh.GG..+N..FL...GluYlllGulshlhulhh.hlhhhh.h.p......p...............................................	0	183	288	415
+1503	PF02611	CDH		CDP-diacylglycerol pyrophosphatase	Bashton M, Bateman A	anon	COG2134	Family	This is a family of CDP-diacylglycerol pyrophosphatases, EC:3.6.1.26.  This enzyme catalyses the reaction CDP-diacylglycerol + H2O <=> CMP + phosphatidate.	25.00	25.00	26.70	26.60	24.00	23.90	hmmbuild  --amino -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.54	0.70	-5.10	24	718	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	658	2	75	359	4	208.40	62	86.80	CHANGED	ssDALW+IVpppClst.ppssssuPCspV..c.....ptGhVlhKDtsGshQYLLhPTt+loGlEuPtLhpsssPNaahtAWpARsahupchGpslP-ssluLAINSphGRoQsQLHIHIuClpPslpptLspts....sshsspWp.LPh.L.....pGHpYhA+pVsss-hspt..sPFphLsccl..tupscMuchululsshssss....FlLLsophchhshs.uSAEElQDHsC.plhc	..............................................................................sDsLRKIVhEpCLPs.Qpps.QNPuPCAEV.....KP....sAGYVVhK...D.hpG.P.LQYLLMPThRIsGhESPLLh-PuTPNFFaLAWQARsaMScKYG..pP......lPDpAVSLAINSRp..GRTQNHhHIHISCIRPDVRcQLDssL.....ssIoo..RWhPLPGGL...........tG..H-YL..ARRVTESELsQR..SPFhMLAEEVP.-AR-+MGpYGLAhVRQSDsS.....FVLLATpRNLL.T..LN........RASAEEIQDHpC.pIL.p....................	0	9	33	55
+1504	PF03598	CdhC		CO dehydrogenase/acetyl-CoA synthase complex beta subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.60	20.60	20.60	22.80	18.10	16.30	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.37	0.70	-6.01	22	260	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	146	27	85	256	20	281.80	45	67.47	CHANGED	tl-IPVshuPsaEGERIR+sDMaVEhGGs+.o...uhELVpshph-E.lEDGKlpVlGPDIc-h-.EGs.phPluIll-luG+chpcDaEsVLERRlHcahNYspGlMHlsQRDhsWlRlSK-AhsKGhp.LcHlGclLhshh+pEF.sll-+lpVTlhTDtpcV......pchh.ppA+thYcpRDcRh+sLoDEsVDsFYuCsLCQSFAPoHVCllTP-RsuLCGAlsWhDu+AuhclsPsGPp.PItKGcslDsptGpapuVN-hltcpSpGsl-+lsLYSlhppPhTSCGCFEsIshhlPEssGlhlVsR-asGhTPsGhsFSTLAG.sGGGtQsPGFhGluhpYhpSpKFlpADGGhpRlVWMPKpLK-plp-pls.........c-hhDKIAsEpsuoo.EElhtFLccpsHPslsh.......-sh.	...........................h.h.hush.tGE.lRt.ph.hEhsG.p.....shEhl.h.....tp....htDtplplhG.-lt..p.h.......u.........s........hu..hhhpl..G.cth.p.D...hEs....lh..ERphH.hhshh...pGhh.+..h..sQ..R.....hhRlsKtshttGht.hpphuphl..hhhtch.shl-phplhhhTp..tth.......p.h...s...at.RDt+htt..h.--ts-.aYsC.hCQsFuPsplChlsP-R.uhCGuhsaLDAKAstclcPsGPsQslsKtpslDEphGtapsVNEhVpchSpGslEcVsLYSlhcpP.TsCGChEslhhh.P..sGhhhspRta..s.sP.Gh.FsthAu.huGG.p..GahGhsh..h.p.+hh.u-.GG..RhlWhst.hKp.l...h............phhthlssEp.s.t.ttl..al...........................................................	0	37	65	75
+1505	PF03599	CdhD		CO dehydrogenase/acetyl-CoA synthase delta subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.24	0.70	-5.97	9	289	2012-10-03 05:58:16	2003-04-07 12:59:11	11	5	140	16	156	518	200	303.70	26	74.61	CHANGED	EVslGs.......pcpsVhlGG-csLaR....a-hsh.N.sslshDV.D.h.st..Ksltcchpclhpp...at+hpVtc.hshDhlsI+thSsDP.......cchscslEcVhpulshPlllsu......DP-VLctAhEVscsc+sLLhuAsh-.sacchschAhcYspsVls.au.tDlsthKsLs+plhp.sGl..ccIVhDPsT.ts.G.GlchohsshhpIRhsAlcG.Dc-lsaPI.uhsssAahsc............u.hVs.............................................pP.ts-ssh...Gss-.cuPla.hTs.............................GlshulAGspl.......................hhhl.PshsAsL+thhEshTGhpshVGstDsutlhshl	......................................................ltlGs.......tppshplGG-s..s..L..ap...a..-tph....s.shluhcl.Dh.hs.p...t......pshhpth...pc....l..p..........plt..p..hts..-hl.sl.+..h.....h...u..s..c.s....................cchspslc.p.V.h.p.s.s.c..hPlllhus.....Dsplhctsh....csst...sc..p..sLl..h..u....Astp.....N....a..ct..hst.h.A.ht.as...t..s.....lhs.............u.................h......-..........l.......s....h..........h....c..........p..........L..........s..h..........h...........l...........t......p....hGl.............cclVhDs...ss.ts.......u......s....l..c.sh....s.sh..p.lRhu.A.lpt.Dc.lshP.h.h.s.h.s.h.p.sh....s.p..................................................................................................................................................................................................................................h...................................................................................................	0	73	128	142
+1506	PF02234	CDI		Cyclin-dependent kinase inhibitor	Bateman A, Mian N	anon	Pfam-B_1698 (release 5.2) & Pfam-B_5787 (Release 8.0)	Family	Cell cycle progression is negatively controlled by cyclin-dependent  kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.	20.70	20.70	21.20	22.00	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.62	0.72	-4.17	43	388	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	133	2	195	364	1	50.30	34	25.13	CHANGED	Rshhh..Ps.cpElcc.aptt.cc.pcchpc...KaNFDFhs-pP.L..s..GR...Y-W.c..ls	......................thFs...Ps.p..pElp.c.hptthp..p....h..pcptpc...KWNFDFhs-pP.L....p..G..+....acWpcl..............	0	39	84	138
+1507	PF03261	CDK5_activator		Cyclin-dependent kinase 5 activator protein	Mifsud W	anon	Pfam-B_4160 (release 6.5)	Family	\N	25.00	25.00	42.40	27.30	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.29	0.70	-5.11	5	198	2012-10-03 00:42:12	2003-04-07 12:59:11	10	3	77	10	122	170	0	210.00	37	88.33	CHANGED	MGTVLS........LSPuS.....RpusLa--.tcs...GussLusYTusssuKuuKu..EKsL.......KRHShlIsALoWKRLVAutSsKKKsSKKuosN...............sSSuYpspltpLN+ENlcKS...........hPhs..h.LsssNhuoacp............................sPupssAPs....supLuuKss.s...............lus.csAPs.t.susGtoP+RVIVQASTSELLRCLG-FLCRRCYRLKcLSPuDsVhWLRSVDRSLLLQGWQDQAFITPANVVFVYLLCRDVlsG.E...luo-cELQAslLTCLYLSYSYMGNEISYPLKPFLVEssKEsFWDRCLslIsphSsKML+INADPHFFTQVFoDLKNEGsp-	....................................................................................................................................................................................................................................................................................................h.......K+.....h.s.hsh+.hs.....tt...t..t............................................................................................................................................................................................................................................................t+hll.QASTsELL+sLG.Flpp..............+C.........tl.pp.....hpssc.lhWhRsVDRuLLLQGWQD.uFls....PANlVFlYhLsR-.ltt.p....................tp.t-Lpu.hLTCLYluYSYMGNEISYPLKPFLl..-ss+-tFWpRCl.llp.hSspMLplNspstaFTplFt-LKt.....t....................................	0	27	46	88
+1508	PF05174	CDRN		Cysteine-rich D. radiodurans N terminus	Yeats C	anon	Yeats C	Domain	This domain is found individually and at the N terminus of a few multi-domain proteins. 	25.00	25.00	102.00	101.10	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.58	0.72	-4.50	5	6	2009-09-10 20:04:58	2003-04-07 12:59:11	7	5	1	0	6	7	0	55.30	73	18.45	CHANGED	phastsLEQFSELRVRRNSTATRSIL.......RPAhCFALAPLA......KKLCHLFVKCSRLs	....astsLEQFSELRVRRNSTATRSIL.......RPAhCFsLAPLA......KKLCHLFVKCS+Ls.	0	6	6	6
+1509	PF03498	CDtoxinA		Cytolethal distending toxin A/C family	Griffiths-Jones SR, Bateman A	anon	PRINTS	Family	\N	21.60	21.60	21.70	21.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.12	0.71	-4.83	10	430	2012-10-02 19:42:32	2003-04-07 12:59:11	9	1	170	6	23	258	3	145.30	32	69.60	CHANGED	hlSlhu.toGulLosathss+sal...Wshs.lcos-auch+s.phhsh.shGhlpF+Nsssus.Clss...htsGhhtst..Csss....shpplFsLlPosoGAVQIKS..lusGpClpsshssph....hhhslplscC..shup...psshsphWhIsPP...spsspP	.........................................loIhu..oGhsLosathsstshl...Wshp.lsup.shtc.tRs.plh....s.saVphpNs.+sss.CLss......hts.Gh....hth...........Cpps......shtphF.....plhP.h.os..GAl....QI+s.....lsss..pClps...hsssh.....h.hpht.lscC.....s.th...ptshsp.ahlosP....htA.....................	1	3	15	19
+1511	PF00272	Cecropin	cecropin; 	Cecropin family	Finn RD, Bateman A	anon	Prosite	Family	\N	29.40	29.40	30.00	29.70	28.90	29.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-7.00	0.72	-4.39	28	182	2009-09-11 13:43:56	2003-04-07 12:59:11	14	1	57	10	56	210	0	30.50	49	49.92	CHANGED	chhKKlE+sGpplRDAlIp....AuPAlsVlupA	.KlhKKIE+lGp+lRDAhIp....Ap.AlsVlusA...	0	15	26	47
+1512	PF02927	CelD_N	celD_N; 	N-terminal ig-like domain of cellulase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.04	0.72	-3.73	42	561	2009-01-15 18:05:59	2003-04-07 12:59:11	9	36	362	16	169	519	19	88.60	25	12.13	CHANGED	sstsstsss...tl+VNQlGYhPsusKhAslsssuss.....s.taplhsusGss.VhsGpspst.uspss.....................SGppV+hlDFSshp.ssGs.YpLpl..sGt..pSt	.................hs...........lhlNQlGYhspu.s.KhAslhss.psp......................s.pap..l......h...s...s.sspp...Vh.p.Gphp.t...ss.st............................st.pp..ht.h.lDFSshp.ssGp.Yhlph..ssh.....p.....................	0	100	148	161
+1513	PF03500	Cellsynth_D		Cellulose synthase subunit D	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.30	21.30	21.70	21.80	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.94	0.71	-4.51	2	86	2009-09-10 23:58:10	2003-04-07 12:59:11	8	1	83	16	36	84	2	124.90	30	81.81	CHANGED	FoLFLQsLSWEIDDQsGIEVRN-LLREVGRGMusRl.PP.CpTlcpLQIELNALLuhIsWGhVpLELLuE-QuhRIVHEsLPQVGSAGEPSGTWLAPVLEGLYGRWlTSQsGAFGDYVVTRDVDAEDLNuVPpQTIIhYMRsRS	..................hth.....................pshL+phGpplAppaPLPsucTlu-LEpslNtlLschsWGaVplc..sp-suLpltHpAhPh...s..stucst.t..pW...h...s...A.lLEGlYupWLpuQuG.u...............................thsh.t.t................	1	1	9	23
+1514	PF03552	Cellulose_synt		Cellulose synthase	Bateman A	anon	Pfam-B_1346 (release 7.0)	Family	Cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues, is the major component of wood and thus paper, and is synthesised by plants, most algae, some bacteria and fungi, and even some animals. The genes that synthesise cellulose in higher plants differ greatly from the well-characterised genes found in Acetobacter and Agrobacterium sp. More correctly designated as 'cellulose synthase catalytic subunits', plant cellulose synthase (CesA) proteins are integral membrane proteins, approximately 1,000 amino acids in length.  There are a number of highly conserved residues, including several motifs shown to be necessary for processive glycosyltransferase activity [1].	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	722	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.18	0.70	-6.24	15	1407	2012-10-03 05:28:31	2003-04-07 12:59:11	9	33	149	0	613	2401	43	403.60	33	73.03	CHANGED	VDlFVSTVDPLKEPPLVTANTVLSILAVDYPV-KVSCYVSDDGuAMLTFEuLuETA-FA++WVPFCKKasIEPRAPEaYFutKIDYLKDKVpssFVKERRAMKREYEEFKVRINALVAKApK.....................................lP-EGWsMQDGTsWPG........NNsRDHPGMIQVaLG.sGucDl-GNE...............LPRLVYVSREKRPGYsHHKKAGAMNALVRVSAVLTNuPFILNLDCDHYlNNSKAlREuMCFMMDPslG++lCYVQFPQRFDGIDhsDRYANRNTVFFDINM+GLDGIQGPVYVGTGClF+RpALYGY-PPpspch.c.s.........ssCChGp+Kpspstppsp........................................p..pcp-pptshashp-l--s....h..s-.E+t.lhoQpslEK+FGpSslFlsSThhpp.....................GGlPc..sssPAsLlKEAIHVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHsRGWRSlYChPKRsAFKGSAPINLSDRLHQVLRWALGSVEIFFSRHCPlWYGat.tRLKaLpRlAYlNohlYPFTSIPLlsYChLPAlCLlTGKFIlPoLoNhAulaFLsLFlSIhsTulLElRWSGVoIE-WWRNEQFWVIGGsSAHLFAVFQGLLKVLAGlDTNFTVTSKuu.s...tD--FuELYlFKWTTLLIPPTTllIlNlVGlVAGlScAINsGYtuWGPLFGKlFFuFWVIlHLYPFLKGLMGRQNRTPTIVlVWSlLLASIFSLLWVRIsPFlscssusshp.p	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hp.......t.......t.......G.......W.Shhh...........................................h....G.s.s.sh.t.....h.Q.hRW..G.h...............ph.hh.s.p.........s.....sh.....hh............s.......................t.h................th...a.......................s..h.........hhY.h.h.s......h...h........h.......t...........h................................................................................................................................................................................h....h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	59	399	517
+1515	PF03040	CemA		CemA family	Bateman A	anon	Pfam-B_1775 (release 6.4)	Family	Members of this family are probable integral membrane proteins.  Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane [1]. A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself [1]. They are predicted to be haem-binding however this has not been proven experimentally [2].	20.80	20.80	21.00	21.00	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-4.75	53	734	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	614	0	83	652	29	213.40	50	80.88	CHANGED	hu+h.pshsSlpYLhhL...lhlPhhlshhh+phhlpPhlspaW..NspQsplFLNs.QEcpALc+hpchEEhlhhDphl.p.....tsphp.pclphpI+ccslpLschasp-ulpsIhplhoslluhshhsshhlhG+cc.LtlLpSalpEhlYuLSDThKAFhIlLhTDlhlGFHSPHGWEllIsulhcHaGhscNcp..hIshFVuTFPVILDTlFKYWIFRYLNRlSPShVsoYHsMNE	..................................................t+hKshsslhYLss..l...VhLPWhlshs..hpKs.LEsWl.s.N...WW.....NTtp...Sc...hh...lstlQEc...s...hLc+F.hcl..EELhlL-cMl.c................-....h.s..pTH...........Q...c..l..c..ItI..HKETIQLlchaNE-p.lchIhHh.TNlIsFshlSuah..............IL...Gpcc.LsILNSWlQEFhYsLSDThKAF.ILLlTDLhIGFHSsHGWELhIsulhcc.aG..hs..cN-p..IISsLVSTFPVILDTIhKYWIFRaLNRlSPSLVVIYHSMN-.....................................................................	0	16	53	72
+1516	PF03879	Cgr1		Cgr1 family	Wood V, Bateman A	anon	Wood V	Family	Members of this family are coiled-coil proteins that are involved in pre-rRNA processing [1].	22.50	22.50	22.60	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.22	0.72	-10.74	0.72	-3.88	18	165	2009-09-10 18:08:07	2003-04-07 12:59:11	9	5	161	0	121	151	0	105.60	41	66.03	CHANGED	pst..scGhRlNGKsW+spKcsFRssu.......phTSaEpRtpcRhpppthKt+EKELK-EKEspRp....p+IptlK-RRttKEEKERYE+MAtKMHtK+VERh+RREKRNKhL+p	...................s..scGhphsGKsW+s.s.Kp..s.FRsps.....................t.hTSaccRhpcRtptpthKp+pKElK-EKEs-R.p.....p+Ipt.l+-RRttK.EE.+....E.R.Y.E+hAt.K......M.H.t.K+...VERhKR+EKRNKhLpp..........................	0	35	66	103
+1517	PF04752	ChaC		ChaC-like protein	Mifsud W	anon	Pfam-B_3722 (release 7.5)	Family	The ChaC protein is thought to be associated with the putative ChaA Ca2+/H+ cation transport protein in Escherichia coli. Its function is not known. This family also includes homologues regions from several other bacterial and eukaryotic proteins.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.26	0.71	-4.32	15	1371	2012-10-02 16:39:48	2003-04-07 12:59:11	7	12	1051	0	511	1064	243	169.70	37	77.62	CHANGED	lWVFGYGSLlW+PuFsas-phhual+Ga+RpFh.ssscHRGTscpPGRVsTLhcs.t.........................utshGsAY+lsutph.ttslpaLp.REh..sG.ptppl.hh...................psssspssh.psllaluos...pNptYhGss.sl-chAp..............pIssAsGsSGsNt-YLFpLtctLcpls............................hcDcaLhcLtptVcct	.................................................lWlFGYGSLh........W...p.....Psh.....t.......as..E......ph........s.up.ltGa+RsFh.h.............t....sp....s.tRG..Ts..cpP..GRsluLcc..u...............................................................GpshGl..AYRlst..p..p.h..cp..t.lphLhcREh...hs.....t.phlshah.............................................................p..ss.st..h......pA......lsalhs................cpspYt...ust...sh...pslAt..............hIusAsGs.GsNt-YLhpLtptLpphG..............................hpDctLppLhttVt..h..................................................................................................................................................	0	128	251	387
+1518	PF00195	Chal_sti_synt_N	Chal_stil_synt; 	Chalcone and stilbene synthases, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase.\	  The differences in activity are accounted for by differences in this N-terminal domain.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.48	0.70	-5.11	21	3069	2012-10-02 12:25:54	2003-04-07 12:59:11	14	18	1289	101	485	4736	327	174.40	49	54.42	CHANGED	sslEph++AQRA-GsATlLAIGTAsPsNsVsQusYPDYYFRlTpSEHhs-LK-KFcRhC-+StIKKRYhaLTEElL+cNPslCsahuP.SLcsRQ-IslsEVP+LGKEAAtKAIKEWGQPKS+ITHLVFCTTSGVDMPGADYQLo+LLGLpPSVKRlMhYQQGCaAGGTsLRLAKDLAENN+GARVLVVCSEhTslsFRGPS-s+...hDsLVGQALFGDGAAAlIlGoDP	................................................................................................................................................................................................................t.....h....h..........p........h.h...t..t..............s...lppRh..hh.....h..................................................t.......................h...............................................s...s....h.....p.Rp.c...h...h..h.....c...s..s..c.L.up.-.AAhc.Al...c.....E.....W......G.....t.....s..t.....o....cI.TH.l.l.h......s.T..o..o..G...l.s.......h....P..G..s..D.h..p.Ls.p.hLG..L.+..s.oVc..Rlhh..a..p....G..CaAG.us..........s..L.R.h.A.K.D...L....A....E....N....N....t....G....A..R.V.LV..VC...SE....l.T....u..l..o.....F...R......u.........P....s...-...s...+..................L.-u.L....V.......G..pA.....L...FGDG.A.A.A.l.I.V.GuDP.............................................................	0	109	314	416
+1519	PF02797	Chal_sti_synt_C	Chal_stil_syntC; 	Chalcone and stilbene synthases, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain of chalcone synthase is reported to be structurally  similar to domains in thiolase and beta-ketoacyl synthase.   The differences in activity are accounted for by differences  in the N-terminal domain.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.90	0.71	-4.29	21	3003	2012-10-02 12:25:54	2003-04-07 12:59:11	10	16	1211	100	498	3983	257	132.70	50	39.80	CHANGED	ELVSAuQTlLP-ScGuIsG+LpEhGLTFHLh+DVPtlIScNIEcsLhcAFsPlGIs......DWNSlFWlsHPGGPAILDQVEtKLsLcPEKLcAoR+VLSEYGNMSSACVlFlLDEMRKpShccGtsTTGEGL-WGVLFGFGPGLTlETlVL+SVs	.........................................................................phhtuuQTllPDS-...uA.IsG+.L.R..E.s..G.....L..T.F.H.L..h.+.-.VPsLISc...NI.c...c..s..L.......sc.A..F....p......s...l......G..I.o.................D....W...N...s..l....F..W..I.u.HPGGPAILD...pV..Et+L.......sL..c..c.....K.lcuoRcV...L.uEYGNMS.....SAs..V.LF.l.L.D.-.h..R.c.p..........s..........h.....p....p.......t.....................t.......p..........................h.....c....hG............l...hhu.aGPGhshEhh......................................	0	132	331	436
+1520	PF02431	Chalcone		Chalcone-flavanone isomerase	Mian N, Bateman A	anon	Pfam-B_2073 (release 5.4)	Domain	Chalcone-flavanone isomerase is a plant enzyme responsible for the isomerisation of chalcone to naringenin, a key step in the biosynthesis of flavonoids.	23.00	23.00	23.10	23.10	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.18	0.71	-4.92	60	585	2009-09-11 05:35:35	2003-04-07 12:59:11	10	8	320	25	257	589	20	182.60	24	69.08	CHANGED	FPss.l.p.ssss.........................pshhLlGt...................GlRslshh...tlKhhulGlYlpss.........slspltsphpucssp....................................-hpcu.phacsllsu.sh..cphhRlshl+s.lshpphp-tlscslhuphpths....................hs......-ppspAlccFpph...F..psc.shPtGsslhhph..sssG.s......Ls.luasppsp...............tpthuslcsch........lucslhppYl.GcpslSPss+cSluppls.sl	............................................................................................pth.LhGh........................................G..hRshph.....lphhulG.............lYlptp...............sl.t..h..tt..hhtp.st....................................-.tps.thapslls....s....s...h...cphh+lshl.hs.lshpphp-thtcshhsphpphsh............................p...-sttpul...cc..Ft.ph.....F....psc.shs.Gsslhhph.sssG..s..............Lp..lshs.t..................tp.thuslpsph...........lscslhp.al.Gcp.ssS.ts+pslspth.t.........................................................................................................................	0	78	167	221
+1521	PF03502	Channel_Tsx		Nucleoside-specific channel-forming protein, Tsx	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.50	20.50	21.40	20.80	20.10	19.30	hmmbuild  --amino -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.70	0.70	-4.57	44	1502	2012-10-03 17:14:36	2003-04-07 12:59:11	8	2	831	6	162	633	25	237.30	33	88.51	CHANGED	tsshpWhphshhhu.t.phs.....pps-....csYLEhEaGG+suhhDLYGYlDl.slt..sspsscp...ttt.sphFhchtPRhSlDthoGcsLuaGPhpElYh.......us.hsast.............................s.ss....hhhGlGsDl.sshhsphshNlaupYshpsh..............pasGaphp.ssWhtPahhhtssshloapuah-apFutcpthts.........psssGhshhhulaW+.o-ca.......ssGhsh+hacshh.htst...............huhcooGhuaYhslsYcF	..........................................................................................................................h.p.h.apShslhss.p.chu.......phss......psY.LEhEsuuphsWh-hYGahDh.shhs...tpspst..........s.oshahchcPRhSIctlsssp.hsFGPap-hYh.......As.s...h.as..............................cpss....ahhGlGhDl.oGhshhhphNlYt+Yp.psY...............pasG...aphp..ltahsshs.hhhsupphohpuas-a-asp...Dtu.sssp...........tspsul.s.uuhh..Lths..hs+a.......phulshRYacsththt..s.............hsh.cs.hG.uhhhslsYpF..............................	1	24	50	109
+1522	PF03924	CHASE		CHASE domain	Yeats C	anon	[1]	Domain	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases [1,2].  Predicted to be a ligand binding domain [1].	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.08	0.71	-5.08	191	1214	2009-01-15 18:05:59	2003-04-07 12:59:11	8	223	668	14	443	1200	120	181.20	18	21.82	CHANGED	sstsl.spscacsasps...lhpphsuhpuhs..at.plstpc..h..statpphppp......thst..apl...........t..................sps.hhslhalpPhs.tNppAlGhDhtopst++tAhpc....Atpoups..slouslp..LlQss......ptGhl....lhhPVa.tt.........................t.....pphhGhlhushchsslhpshhtpp.........tplslplhD.................spssssplh.ass	........................................................................................tphtth...htt...h.tt...hssh..u.ht....h......p..lt...tp....h..tthtt...phttp...........h.......hpl........................................tts.hhslta..l...........Phs....tNppsl..GhDh..ts......p..sp..p..p..ps.ltc....Atpssps..slouP.......lp...L......lQss............t.G.hl..lhhPVa...p.t.....................................tp.................pphhG..........h.lsushchsslhpshhh.tt............plslplhD..................ts.tt...hh..............................................................................	0	131	283	371
+1523	PF03173	CHB_HEX		Putative carbohydrate binding domain	Bateman A	anon	Pfam-B_8666 (release 6.5)	Domain	This domain represents the N terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure that is similar in structure to the cellulose binding domain of cellulase from Cellulomonas fimi [1].  This suggests that this may be a carbohydrate binding domain.	25.00	25.00	26.20	25.30	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.97	0.71	-4.79	6	353	2012-10-01 21:34:18	2003-04-07 12:59:11	8	7	306	4	75	309	10	155.80	34	18.70	CHANGED	sNLclphpllcshsuppshsCssht......s.huuCh+lphohsspspsscuc.DasIYFpSl+hshps-u-pFtIsHlsGDLHKLpPTstFuGhsuGcohslplsuphWQlhcoDhhPphal...ousstcPcsltsTs.......TE.........-lstFlsshs...ssQhKpTscDpsshtsuss	.........................................................LtlphplhsNpuuptGhsCttht.........A-hAuCsps........phsLs........NpG.pss......uc.DWsIYFp.S.I.Rh.l..........L........p.l.s.s.s.......p..............F...........p.ls+loGDLa+lpPTcpFsGhusG-slplPhluEYWplhpoDhhPphal........sussAcP.clltshs.......T-..........DhstaVpshp.......sp...ph..+R..o.....s...Dps.hhps..t.....................................	0	18	32	55
+1524	PF03174	CHB_HEX_C		Chitobiase/beta-hexosaminidase C-terminal domain	Bateman A	anon	Pfam-B_8666 (release 6.5)	Domain	This short domain represents the C terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure [1]. The function of this domain is unknown.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.92	0.72	-4.14	264	1239	2012-10-03 16:25:20	2003-04-07 12:59:11	8	244	639	4	431	1707	370	74.60	23	9.83	CHANGED	ssshhssssG.shts...s.pls.....lss.tpsss.....sIaYThD.GopP........ots..S.phY..................s.s..P.lsl..ss.s...........l+shuh..sss.tpsSpltotp	..............................h....h.s.sG...h.t.....stpls.......l..ss..ttsss......pIhY.Th..D.G.o.p.P..............................s.t........S..th..Y.................................s..s..P..l.slspss.s............................l+shuh.....sss.tp.Sphhp..t...............................................................................................	0	199	339	396
+1525	PF01339	CheB_methylest		CheB methylesterase	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	20.40	20.40	20.60	20.60	19.90	18.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.97	0.71	-4.85	180	3655	2009-01-15 18:05:59	2003-04-07 12:59:11	12	120	1959	4	1223	3093	363	180.30	37	42.15	CHANGED	llsIG.uSsG.GspALppllsp...LPs.shs..h.sllllQHhsss.assthschLsptsslsVpp.Ap-Gp.hl..ps...GplYlAPsst.clt...........l..........p...ssp..........htlpht.....sthstt....+..Pol.DshFpSlApthusps.lullLoGhGsDGupGlttl+ptGGh.sl..uQct.pouhhhGMPcuAlp.sG.ssDtllshpcluptl.hph	..........lluIGuSTG.GspA..LpplLps.LPs..shP....sl.l.l.....s.Q.H.MPss..FT.p..uhA...c+L.s.ph..s.p.l.s.V+E.A.p-.G-..hl...ts...GpsY..lAP.G.sp.Hhtl.........tp....sup...................................lplptt.......ssssta....+..PSVDlLFcSsA.c..t..h.G.p.ps.lGVlLTGMGsDGAtGhhtl+.p.s.G.u.h..s.l..AQ...cE..so..s..l..VaGMP+t.Alp.h..G.ssspllsLsplupplh..h................................................................................	0	399	770	1013
+1526	PF04509	CheC		CheC-like family	Waterfield DI, Finn RD	anon	COG1406	Domain	The restoration of pre-stimulus levels of the chemotactic response regulator, CheY-P, is important for allowing bacteria to respond to new environmental stimuli.  The members of this family, CheC, CheX, CheA and FliY are CheY-P phosphatase [1,2]. CheC appears to be primarily involved in restoring normal CheY-P levels, whereas FliY seems to act on CheY-P constitutively. CheD enhances the activity of CheC 5-fold, which is normally relatively low [1,2].  In some cases, the region represented by this entry is present as multiple copies.	20.20	20.20	20.20	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.22	0.72	-4.22	33	1993	2012-10-01 19:50:22	2003-04-07 12:59:11	7	14	662	13	597	2015	46	37.70	36	24.19	CHANGED	httuAlpEluNIhsGsssouLuphht.tpl-hosPslth	......phsulpEluNIhhGsAuTuLSphls.pplslosPpl..h..............	0	261	447	522
+1527	PF03975	CheD		CheD chemotactic sensory transduction	Bateman A	anon	COG1871	Family	This chemotaxis protein stimulates methylation of MCP proteins [1]. The chemotaxis machinery of Bacillus subtilis is similar to that of the well characterised system of Escherichia coli. However, B. subtilis contains several chemotaxis genes not found in the E. coli genome, such as CheC and CheD, indicating that the B. subtilis chemotactic system is more complex. CheD plays an important role in chemotactic sensory transduction for many organisms. CheD deamidates other B. subtilis chemoreceptors including McpB and McpC. Deamidation by CheD is required for B. subtilis chemoreceptors to effectively transduce signals to the CheA kinase [2]. The structure of a complex between the signal-terminating phosphatase, CheC, and the receptor-modifying deamidase, CheD, reveals how CheC mimics receptor substrates to inhibit CheD and how CheD stimulates CheC phosphatase activity. CheD resembles other cysteine deamidases from bacterial pathogens that inactivate host Rho-GTPases. Phospho-CheY, the intracellular signal and CheC target, stabilises the CheC-CheD complex and reduces availability of CheD [3]. A model is proposed whereby CheC acts as a CheY-P-induced regulator of CheD; CheY-P would cause CheC to sequester CheD from the chemoreceptors, inducing adaptation of the chemotaxis system [4].	25.00	25.00	34.30	27.90	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.33	0.71	-4.31	150	1074	2009-11-17 14:42:28	2003-04-07 12:59:11	8	8	935	2	412	920	66	114.90	30	61.85	CHANGED	MLPsssttptt.........ss.s+YushAh-hLlscll+hG.Ap+ppLpAKlhGGAphhs........shhsIGpRNschs+chLpppsIsllucDlGGstuRplhF.s.poGclhl+pl..........tpt.p.....h	................MLPpsstspst..........sss+YushAhchLlschl.c.h.G..A.p.....+..p..cLpAKlhGGAphhs..................shhslGpRNschscchLpppsIsllAcDlGG.s.tuRplhF.s.poGclhl+pl........t......t...........................	0	151	288	351
+1528	PF01739	CheR		CheR methyltransferase, SAM binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_694 (release 4.2)	Domain	CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase - the C-terminal domain (this one) binds SAM.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.07	0.71	-5.02	22	3912	2012-10-10 17:06:42	2003-04-07 12:59:11	13	179	2109	2	1263	3557	543	191.20	32	48.37	CHANGED	NhTpFFR-stpFchLpppll.s.l.phptt...pp.l+lWSAuCSoGcEPYSlAhsltc...hh.sshs..thpIhATDIshpsLppA+tGhYspptl.psls.thhp+YF.ctsstsap....lpscl+phVpFchhNLhs.....shhsphDlIFCRNVlIYFcppsppcllp+htstLpssGhLhlGpSEsls.thsshFphhpsshthh	.......................................................NhTtFFR-sppFphLpcpll...h..t.ptt..................tp..lRlWSAuCSoGEEPYS.lAhhLt-............hh...p.h....h...s.......phpIhATDIss..ps..L..pc..A..+....pGlY...s.......tpp.......l........c........s......l.s.................p...h........h........p.........+........a...F..........c.......t.....p........s......s...p...ap.................lppp.l.+p..hV..p.F..pphNLlp..............h....s.......h......h....s.........p....a.....D...lI.h.C....R.N.V.h...I..YF.c....p.p...s....p.pc...l.lppFt.t.t.Lp.ss.Gh..La..l...Gp...oEsls...th..sphap.h.......h...................................	0	424	817	1056
+1529	PF03705	CheR_N		CheR methyltransferase, all-alpha domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_694 (release 4.2)	Domain	CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.39	0.72	-4.60	77	3379	2009-01-15 18:05:59	2003-04-07 12:59:11	10	136	2012	2	1043	2654	197	56.40	24	14.23	CHANGED	scpchptltphlhppsGlslss.hKpshlppRLt.pRhcthslpshscYhphL...pssppp	..................ptcappltphlhppsGIsLss..tKcshlhpRLs.c+.l..c.t...h..s..l..s..sascYhphL...pps.....................	0	348	678	867
+1530	PF01584	CheW		CheW-like domain	Bateman A	anon	Pfam-B_579 (release 4.1)	Domain	CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis.  The CheW-like regulatory domain in CheA [1] binds to CheW, suggesting that these domains can interact with each other.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.71	247	10977	2009-01-15 18:05:59	2003-04-07 12:59:11	14	74	2190	12	3275	8780	671	135.50	21	33.57	CHANGED	phlhhpluscp........aulsltpVpEllph..sp.hsplspss.shh.......Gl.lslRG....pllPllcLpphhshsstp................tppshllllc..hs.................sphhGllVDplhshhplshcslpss......hs...thsshlpGsshh.......cu......p...............llhlLDlppllpt.t	............................................hlhhp.lu.scp.........aulslt.pVpE..llph......sp..hs...pls...p...ss...shh..................Gl.l.sl..RG.........pllPll..c.L.p..p.h.h.s...hsssp....................................................tppshll.llp....hs.................pphh.Gll.VD.plhs......h.h.p..l....sh.c.s..lpss.................ht...t..ss.h..ls.Ghshh.............cs.........p.....................lhhllDlppllt...h.............................................................................................	0	1032	2073	2737
+1531	PF01111	CKS		Cyclin-dependent kinase regulatory subunit	Bateman A	anon	Sarah Teichmann	Domain	\N	20.90	20.90	21.90	22.20	18.10	20.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.52	0.72	-4.14	33	488	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	312	20	323	442	1	71.50	58	58.47	CHANGED	pIhYS-KY.DDp.aEYRHVlLPK-lsKhlP+s..........+LhoEsE.WRsLG.......lQQS.GWhHYhlHcPEPHILLFRRPhs	.........................IaYSs.KY.D-p.aEYRH.....VhLPKcl...sKhlPKs.........................+LhoEpE.WR.s.LG.......lQQ........ShGWhHYh.lH..cP.EPHILLFRRPl.............	0	119	178	263
+1532	PF04344	CheZ		Chemotaxis phosphatase, CheZ	Mifsud W	anon	COG3143	Family	This family represents the bacterial chemotaxis phosphatase, CheZ. This protein forms a dimer characterised by a long four-helix bundle, composed of two helices from each monomer. CheZ dephosphorylates CheY in a reaction that is essential to maintain a continuous chemotactic response to environmental changes. It is thought that CheZ's conserved residue Gln 147 orientates a water molecule for nucleophilic attack at the CheY active site.	26.70	26.70	26.90	26.70	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.47	0.70	-4.68	60	1206	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1062	4	279	728	51	184.90	44	83.43	CHANGED	ssplapclGpLTRpLH-uLpshtlDp+l.......ctAsscIPDA+-RLsYVlchTEpAAs+ThsAVEtuhPls-pLpspspplpspWpchhppplphs-....F+pLscchcpaLpp.sppsosplpspLsEIlMAQDFQDLTGQVI+RVlsLVp-lEppLlplLh.hu.scpp.tht......................pGP.lss-p+sDVVsuQD-VDDLLuSLGF	.............................................s..clhtcIGpLTR.L+-SL+-L...u..lDptl.......tpAs-sIPDARDRLtYVlpMTtQAApRsLsuV.......EtupPhp-phcpp...Ap.tLp..tcWsc......hht..s......I...-ls-................h...R...pLspcsc.paLtp.Vstc.ouh...ssupLhEIhM..AQDFQDLTGQVIKRhhcllpElEcpLlhl.....Llpsh...sp...ppt.cstc..ps................................psL.hNG.PQl....s..s.....p..+..s..s....V..V.....u..SQDpVDDLLsSLGF....................................................................................	0	63	151	211
+1533	PF00187	Chitin_bind_1	chitin_binding; 	Chitin recognition protein	Finn RD	anon	Prosite	Domain	\N	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-8.90	0.72	-3.97	18	1066	2010-01-08 13:37:10	2003-04-07 12:59:11	14	39	234	154	390	1128	1	38.80	51	11.02	CHANGED	ApQCGpQuGGthCPssLCCSpaGaCGoTs-YCGs..GCQ.SpC	.................ppCG.........s....s....t....hC....s...s......s......l...CCSpaGaCGoTs-Y..C......Gs...........GCQ.u.C...................	0	83	225	335
+1534	PF01644	Chitin_synth_1	Chitin_synth; 	Chitin synthase	Bashton M, Bateman A	anon	Pfam-B_892 (release 4.1)	Family	This region is found commonly in chitin synthases classes I, II and III. Chitin a linear homopolymer of GlcNAc residues, it is an important component of the cell wall of fungi and is synthesised on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases [2].	25.00	25.00	25.10	29.30	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.82	0.71	-4.46	14	884	2012-10-03 05:28:31	2003-04-07 12:59:11	12	12	402	0	349	874	2	143.70	53	23.85	CHANGED	MYNED-lLFsRThHGVMKNIuHLCoRp+SpsW..GtDuWKKVVVCIVSDGRsKlp.RsLshLAulGVYQ-GlAKs.VssK.VpAHlYEYTTQlSIDsshpacGsc....+GlsPVQllFCLKEcNpKKINSHRWFFpAFu.lLpPNlslLLDVGT+PuspSIYpLWKuF	................................................hYNEsch..hhsRThtulhpNIt.hsp.....h....p......p......SphW...........G...t......s..uWpKIVVClVuDGR..sKls.RThslLAuh..GVYQ.-.........G.lA..Kp.......p.VN..GK.-V.sA.HIY..E..............YTTQ..lu..l.s.....p.tp..h....h.t.hp.............pshsPVQhlFCL.KEKNpKK.INSHRWhFpAFuphL.......pPp.........lClL...............lDsGT+Pu.polYpLWcuF.................................	0	111	202	304
+1535	PF03142	Chitin_synth_2		Chitin synthase	Mifsud W	anon	Pfam-B_1787 (release 6.5)	Family	Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyse chitin synthesis as follows:  UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	527	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.68	0.70	-6.12	10	1072	2012-10-03 05:28:31	2003-04-07 12:59:11	10	35	361	0	640	3978	47	331.20	28	34.17	CHANGED	ssshlacslssQPhs-apsaGasLtHTIClVTCYSEuEEGLRsTLDSlAsTDYPsSHKLLlVICDGlIpGuGND+oTP-IVLsMMcDhlsPs--lEPhSYVAVAsGsKRHNMAKVYAGaY-Yss.......pls.ppQQRVPhlVVVKCGTPsEsottKPGNRGKRDSQlILMsFLpKVhFDERMTsLEaEha+sIWplTGlsP-FYEhVLMVDADTKVaPDSLT+MVAsMl+DPpIMGLCGETKIANKcsSWVThIQVFEYYISHHhoKAFESlFGGVTCLPGCFoMYRIKAsKGspshWVPILssPDIVE+YSENVVDTLH+KNLLLLGEDRYLTTLMLKTFPKRKphFVPpAtCKTlsPDoFpVLLSQRRRWINSTVHNLhELVLl+DLCGTFCFSMQFVVFIELlGTlVLPAAIsFTlYlIlhulls...pPsPhIsLlLLAhILGLPAILIllTsR+WsYluWMllYLLALPlWNFVLPuYAaW+FDDFSWGsTRpVpGEct..KcstscsEGcFDsSpIsMKRWcEaERE	........................................................................................................................................................s...................................................................................................................................................................................................................................................................................................................................hllhlDuDs.h...p....u....lphhlt.....h...........p..s.....p..l......huhCG.....p.........h.....t......l.............t..........s.........t.............t......p.......u....h........h.......s.......h....h...............Q....a.....EYh.lua..hh.t..K.uhEu.hh.G.s.VhCh.P.G.CFshaRhps..................t..............................................................t...t.l.h..........p...p...Y...s..p.................s.....-......s.....h..a....h............p.h.........h.........................h..G.....E...DRa..L....o.o....L....hl..p....t..........t....hp....hp.......a....sspAhshThsPc....sap..............hhsQRRRW....h.s........S...T....l....p..N.....h.....h......-........L.......h....h........h........t...p........h.......p.....h.......h........h....p....h.s..h..............h...l...l........h..h.....p....l...h....u.....s....h...lh.......P...s......s...h..h......h.......h...h.....h......h........................h..........h........h.ht.............t.............h..............h.......h........s...h..........h.........h....l...s..h..h.......h..s.....l......h....h.......h..h....h....h.......h...................t...p.h.....h...h...h.....h......h..h......h....h.h...................................................................................................................................................................................................................................................................................................	0	272	404	566
+1536	PF03503	Chlam_OMP3		Chlamydia cysteine-rich outer membrane protein 3	PRINTS, Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	62.80	62.80	17.80	16.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.44	0.72	-3.75	3	38	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	37	0	4	13	0	53.30	81	60.81	CHANGED	CGVVSLSSCCRIVDCCFEDPCAPpsCNPCEs.+KKD+ssGCNuCGoYVPSCSKPCG	.CuVVSLSSCCRIVDCCFEDPCA.PhpCsPCEu.+KKDVssGCNSCsuYVPuC.KPCG	0	1	1	3
+1537	PF03504	Chlam_OMP6		Chlamydia cysteine-rich outer membrane protein 6	PRINTS, Griffiths-Jones SR	anon	PRINTS	Family	\N	27.20	27.20	27.50	31.00	26.80	27.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.32	0.72	-3.73	2	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	44	0	5	50	0	91.30	82	20.13	CHANGED	CaG+MYsV+VNDDpNVEIoQAVPEYATVGSPYPIEIhAsGK+DCVsVlITQQLPCEsEFVpSDPATTPTuDuKLlWpIDpLGQGEKsKITVWVKP	.........CaG+MYoV+VNDDpNVEIoQuVPEYATVGSPYPIEIhAsGK+DCVsVlITQQLPCEAEFVpSDPATTPTuDGKLlWKIDRLGQGEKsKITVWVKP.	0	2	2	4
+1538	PF01308	Chlam_OMP	Chlamydia_OMP; 	Chlamydia major outer membrane protein	Finn RD, Bateman A	anon	Pfam-B_1429 (release 3.0)	Family	The major outer membrane protein of Chlamydia contains four symmetrically spaced variable domains (VDs I to IV).  This protein is believed to be an integral part to the pathogenesis, possibly adhesion. Along with the lipopolysaccharide, the major out membrane  protein (MOMP) makes up the surface of the elementary body cell.   The MOMP is the protein used to determine the different serotypes.	19.60	19.60	19.70	20.10	18.50	19.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.33	0.70	-5.86	4	1235	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	64	0	7	951	0	269.70	66	99.06	CHANGED	MKKLLKSALL.AA.huSsuSLQALPVGNPAEPSLLIDGTlWEGhuGDPCDPCuTWCDAISlRsGaYGDYVFDRVLKsDVsKpFp.MGAsPTusssA....s.oTss-RPNPAYGKHhpDAEWFTNAualALNIWDRFDVFCTLGAosGYhKGNSuuFNLVGLhGlKGoSl...sAsplPNsulopGVVELYTDTTFSWSVGARGALWECGCATLGAEFQYAQSKPKVEELNVlsNsAQFoVpKP+GYhGssFPLPloAGT-sATu..TKsATIsYHEWQVGhALSYRLNMLVPYIGVpWSRATFDADsIRIAQPKLAsAlLNLTTWNPTLLGpuTslsoo.NcFADhhQIVSlQINKhKSRKACGVuVGATLlDADKWulTuEsRLINERAAHlsAQFRF	....................................................................................RhGaYGDaVFDRVLcs.D.VsppFp.MGtt.P..o..s.s..s..sus...s.oo..h..ssR.NPAYG+HMQDAEMFTNAAhMALNIWDRFDVFCTLGAooGYLK.GN.SASFNLVGLFG..sst..p..s.s.....tss....plPNhulsQ...uVVELYTDToFuWSVGARAALWECGCATLGApFQYAQSKPKVEELNVLsNsApFTIpKPKGYVG..t..p..FPLsloAGT-s..ATs.....TKsAoIcYHEWQsuLALSYRLNMhsPYIGVpWSRASFDADTIRIAQPK.Ap..s............lhshTThNPTlhGt..us.s..h..s......s.....s.....s.hsD...........................................................................	0	4	4	6
+1539	PF00504	Chloroa_b-bind	chloroa_b-bind;	Chlorophyll A-B binding protein	Finn RD, Bateman A	anon	Pfam-B_54 (release 1.0) & Pfam-B_5772 (Release 7.5)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.63	0.71	-3.97	157	2672	2009-01-15 18:05:59	2003-04-07 12:59:11	16	22	422	33	911	2617	772	131.40	25	66.18	CHANGED	hPstL.sG....ph...sG-hG........FDPLGLu...t.-s.......................................................thchhRpuElhHGRhAMLuslGhlssEhh.t.........sh.....t.Ps....ahp.ss..............................................h.s......h...hh...lhhhuhhEhhp.tshhs..t.t.........................hhPG..s...............h.FDPl....G.hs.........ts.pphtph+hpElpNGRLAMlAhhGhhsQth	......................................................................................t.......aDsh.t.h.....t...................................................................thth...ptsElhpuR...hAMLGh.h.GhlhsEhhst................s.........t.............hht...s.................................................h...hh......hh.hhuh.h..E..h..h..t..t.h...................................................hPG..s..........................hssh........s.hs..........p.....t....tht.hphtElpNGRLA.Mhuhhuhhhp..h....................................................	0	418	719	840
+1540	PF02962	CHMI		5-carboxymethyl-2-hydroxymuconate isomerase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.30	21.30	21.40	21.40	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.57	0.71	-4.00	3	831	2012-10-01 20:38:22	2003-04-07 12:59:11	10	4	769	15	152	460	70	119.90	39	95.22	CHANGED	PHFhlECTDNIREpuDLP-LFuKVNssLAAo.GIFPlGGIRSRAHWLDTWQMADGQH.DYAFVHMTLKIGAGRSLESRQ-sGDMLFsLIKsHFAALMESRhLALSFEI-ELHPTLNaKQNNVHALF	.........................................PHhlhEhosNlc-ps.cls.s.Lh.pplspsLh......s......o.....G........lFP.l.u.G..IRSRAhh.h-..sap..h...A..DG.........pp....-hAFlHhoL+IGuGRShEs+pplu-t.LFsllps.+.h.As.l.htp+.h.lALShEltEhc...s.h.sa..Kp.NslH......................................	0	18	59	108
+1541	PF04428	Choline_kin_N		Choline kinase N terminus	Kerrison ND	anon	DOMO:DM04048;	Family	Found N terminal to choline/ethanolamine kinase regions (Pfam:PF01633) in some plant and fungal choline kinase enzymes (EC:2.7.1.32).  This region is only found in some members of the choline kinase family, and is therefore unlikely to contribute to catalysis.	20.40	20.40	20.40	21.00	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.53	0.72	-4.50	21	146	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	123	0	97	147	1	62.40	31	9.87	CHANGED	sshtsut.h..s...sp..LD.shs..h............................h+p-lhpllpoLplssWtcls.-tss	................t....ss.ph.lPs..scshLDNShshsY.................................FKp-IlcLh+oLclpuW++ls.p...t....	0	16	47	78
+1542	PF01633	Choline_kinase		Choline/ethanolamine kinase	Bateman A	anon	Pfam-B_1165 (release 4.1)	Family	Choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway [1]. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family. 	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.44	0.70	-4.76	38	1798	2012-10-02 22:05:25	2003-04-07 12:59:11	15	27	951	30	795	4525	1654	199.50	21	51.55	CHANGED	pspplLlRlYGps..s.................chhhsRppEhhshphlucpulGPcLhGhFssGRlE..cFl.sucsLssp-lpssclpttIApphtchHslsh.........................................................hpcpstlapphcca.......................h..pphspppthpthshppLpcElstlcchl.p...............thcps...lVFCHNDLt.uNllh......................................................................psspplhlIDaEYuuaN.tuaDlANHFsEhshshp..t...ahh..chshaPspcp	.............................................................................................................................................................................................t..pthllR.h..h.Gtt....s......................................phh...l.sR..p.p.....Ehh.sh...thl.t.p........hs...h...s......s.........p..h...h..........h..........h....................p........u...t......hp...........ca.....l...p............u............p...s....L..s..s.......p....p...l.......p....p.............t......h....h........p.....t.....l...A....p.t....h......tph.H....s....h.th..........................................................................................................h.p.t...t......t.h.a..p..p......h...p..c..a...............................................................t..t......t.....t...p...t...t..h..........h......h.......p......h....p...p.....l....p.....p...p.l......t.....p...l...c..p....hl...p......................................p..h.t..t.s............hs...hC...H..N..D..........lh....t.Nllh...................................................................................................................................p..p..p.....s.....p....l....h......l...I...D.a...EY..uu..hN.......saD..l..u...s..a........h...h...Eh.t...hs...t..............h.................................................................................................................................	1	255	439	638
+1543	PF04345	Chor_lyase		Chorismate lyase	Mifsud W	anon	COG3161	Family	Chorismate lyase catalyses the first step in ubiquinone synthesis, i.e. the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate.	21.00	21.00	21.30	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.93	0.71	-4.82	3	1188	2012-10-01 19:33:20	2003-04-07 12:59:11	8	2	1158	11	198	690	245	159.80	37	92.75	CHANGED	hLsNATWQpuDDlp.luPulpsWLh-pGSLTRRLssts-.clsV-lLuEuWh...TLpsDEsQtLsscpusssWlREVIL+GcDpPWVFARTLIPRSSLcsQsFDLsQLGsRuLGEhLFSsSshcRssLEVs+scss.......htuLaARRSRhShGAcsMLVAELFL.TPpIao+ssl	.............................................hhh.......................h........lt.s.t...l..h.-WLh..psShT+Rhcpp.s.p...pl.oVp.......hlpEsas...............p......sp..s.Ep.h.L...hs.p.....ps..............h..W.l.REllLpu..D.u..p.P..Wl..huRTll.P.hooL...............pG.s.t...h.s.L.p...cLGppPLGc.h.LF......os.s..s..ls...R...Dhl..-..l...u+ss...............................tL.W.u.RRS+h.ch.s....G....c....P...LL.lTElFL.tssla..................................................	0	34	86	143
+1544	PF01723	Chorion_1	Chorion; 	Chorion protein	Bashton M, Bateman A	anon	Pfam-B_1914 (release 4.1)	Family	This family consists of the chorion superfamily proteins classes A, B, CA, CB and high-cysteine HCB from silk,  gypsy and polyphemus moths. The chorion proteins make up the moths egg shell a complex extracellular structure [2].	20.90	20.90	20.90	21.80	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.54	0.71	-4.39	14	91	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	6	0	62	96	0	136.40	30	89.51	CHANGED	huphlLhlsspALhsQoshSQChuR....luu.t.....Gh.GhsuLG.YpGhGh.sh....GhG.Ghts.h.usus...LsAshGGsLsVso.ousAPTGLul..sSENsY....EGsVuVsGpLPFLGTssVAGphPTuGhGulpYu...CGDGAVuIouEsuh......uhs.s.shs.s.h.us.s.uhu......hGYtshs.GCGC.........Gs	.................................................................s.......h.h.shhhp.hhuph.........h..........................s..s...s.......hs.......Ghuh............uhu...................................htus.G..s........l.s..sshuPsGlsh..tups.th.................-GsluVsGpLPhhGossltGphPs.GhGsVpau...CusGsVuIsscss...............shs..h.......................................................h.............................	1	39	62	62
+1545	PF03964	Chorion_2		Chorion family 2	Finn RD	anon	DOMO_DM03001	Family	The chorion genes of Drosophila are amplified in  response to developmental signals in the follicle  cells of the ovary[1]. 	21.90	21.90	26.90	26.90	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.80	0.72	-3.46	14	51	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	21	0	18	55	1	106.00	35	72.01	CHANGED	GYGusshG...s.u...psh.p................Ytt...........................s+G.ttuYGpt........................t.hhu.sssspAtutAt.u.AussuGs.p.hthPs.cltsu.hGPph.Ga.........G......hGtst	.................GYGusshG....GYuh.spsshp.hsh................uYGs...........................upG...suYGps..........................t.htu.sssupAhAhAphAhAAsssGs.h.at.Pshclpsu..hGPp.ua........h.G...h....t....	0	4	4	13
+1546	PF00425	Chorismate_bind	chorismate_bind; 	chorismate binding enzyme	Finn RD, Kerrison ND	anon	Pfam-B_164 (release 1.0)	Family	This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.	20.50	20.50	20.50	20.60	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.53	0.70	-5.06	163	11419	2009-01-15 18:05:59	2003-04-07 12:59:11	13	52	4438	63	2457	8400	4662	249.70	32	53.38	CHANGED	spppatptlppshpt.I..psG-...hhpls...Lopphphp..t..ths......s.........hslhppLpp......p.ssssashhh.............ph...................................h..luuSPEhhl.................p..hc................plpopPluGT...t.....R....uts.t.........................p......DtthtppLhpspK-psEphhlVDhlRscLuplt....s....so...........lplsphhplpp....hsslhHLsoplpu.pL.pts.hsh..h-llpulaPsuulsGsPKtpAhph....IpclEs.h.......sRGh.YsGslGals..su.....s......s-hslsIRoshh....ps...........hplhuGuGIVtcSssppEapEsttK	.......................................................................s.pppatptlpps.p.ch.I..p..p..G.-........hapVl.lop..phphp....h........hs....................s...........................................hsh.a.pp.....Lpp......t..Nsu.sYhaah............phss...............................................htl..lGuSPEhhl................................c....hc...st...............plpopPlAGT...t...sR...........u.t.s..s..p.............................p.....Dppht.pcL..hsstK...............-puEphMlVDLhRNDl.u+ls.......suo................lcV..s..chhplcp.....a.sp....VhH.......LsS.plpG....p...............L......pt....s....hss..................hc.hl.p.u.ha.PsG...oloGAPK.hcA.h.......pl.I.p.c.l.Es...t............pRGh..YuGulGalsh.....sG.......................s..............h-hslsIRohhl...cs....................................spshltAG.u.GIVhD.SsPpsEapEottK.............................	0	741	1558	2097
+1547	PF01817	CM_2	Chorismate_mut; 	Chorismate mutase type II	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.53	0.72	-3.89	101	5974	2009-01-15 18:05:59	2003-04-07 12:59:11	16	36	4103	55	1304	3816	1745	78.70	27	28.68	CHANGED	RppIDplDcpllpLLscRhplstpluchKppp.....shs.lhcs.pREppllcplhptsc....tshs..sphlpplappIhctuhthppsh	........RppIDplDppllpLLscRhclspcVuchKtpp............shs..lh.cs...pREpplL..pcltptuc........ttsls...schlppl...applhctShthpp..h.............................	0	373	798	1089
+1548	PF01264	Chorismate_synt	Chorismate_synth;	Chorismate synthase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.00	21.00	24.20	24.00	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.01	0.70	-5.96	158	4715	2009-01-15 18:05:59	2003-04-07 12:59:11	16	5	4374	29	1174	3448	3602	336.60	44	93.20	CHANGED	hRhoTaGESHG.ulGsllDGhPAGltlspccIpt-LsRR+..PGt...u+.hso.RpEsDpVcILSGVh.cG......hTsGoPIullIpN....pDh+stcY..........................schtst.RPGHADhshthKY.G..h+DhRGG.GRuSARETAuRVAAGAlA+plLp...phG.....IclhualhplGsh........................phshp.h.......cp......ss..lhssDspstpchtphIcp.s+cpGDSlGGll-llspG......lPsGLGpPl.aD.KLDAcLApAlMSIsAlKGVEIG..sGFpsuphhGSpspDph......hhpst.............hh.pp....oNcuGGl.GGISsGpsIllRsAhKPssolhp.stpTVs.pstc..psplphtGRHDsCllPRAssVsEAMlAllLADthLc	..................................hRhoThGESHG.uLssll-GsPsGltl.stt-..Ipp-.LcRR+sG..t......uR...h.so.RtEs..DpVcILSGVh..cG..........h.T....T.GoPIulllpN...pDp+s...t-Y..................................................................................sp.h..h.st..R.PGHADhshthKY.G..h.R..DhRGu..GRSSARETAhRVAAGAlAKphLt...p......h.G.............lcltualsplGsl.....php........................................................hhs.hp.pl......cp......ss.hhss...D.....ssttpphcphlcp.h+.+.pGDSlGuhlpllspG......lPsG.LGpsV..aD..+LDAclApAlMSINAlKGVElG..sGFpss.phpGSpspDEh.................hh.s.st...............................htoN+uGGl.GGlS............sGp......sIls+hAhKPhsolhp..P.hpols.pssE......pspl..hpGRaDPCls.RAsslsEAMlAlVLhDtlLp......................................	0	394	771	1014
+1549	PF02417	Chromate_transp		Chromate transporter	Bateman A	anon	Pfam-B_1872 (release 5.4)	Family	Members of this family probably act as chromate transporters [1,2].  Members of this family are found in both bacteria and archaebacteria.  The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	28.60	28.60	28.70	28.60	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.96	0.71	-4.66	103	4595	2009-09-10 17:38:28	2003-04-07 12:59:11	10	9	1631	0	1528	4268	786	171.40	25	85.64	CHANGED	shhpLFh..hFh.plGhhuFGGuhuhlshhccphV.cppcWlopcpFhchlAluQhhPGPhslphushlGa+...h......sGhhG........ulsAsluh...hlPuhllllhluhhhtp..hpp..tshhpshhpGlpssslullhssu.....hph.sps.............hhtsh..hshhlh.shs..hlhlhhhp....h.....sslh.lllhushhGhh	...................h.hhplFh.hFh.+lGhhsFGGuhuhlshhp..p..phV....p..............p............h...p..........W....lo.......p...ppFh.chlAluQhhPGPh..sh...phu...sa....lGat.......h................sGhh.G.........................................................ullAsluh...........hLPuhllllhl.uhhhpp.........hpp......ps..h.....l.p.uhhpGlpsu.llullhsus......................hp.h.spp................................shtsh....hsh.s....ls....shs.....h..l.h...l......h.h..h.p..........l..........s.hh...lllhuulhGh.............................................................................	0	510	999	1289
+1550	PF00385	Chromo	chromo; 	Chromo (CHRromatin Organisation MOdifier) domain	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.93	0.72	-4.29	173	5794	2012-10-02 16:56:36	2003-04-07 12:59:11	19	330	405	83	3614	5547	121	53.30	24	6.52	CHANGED	htl-cIl..cp+..hpcptt..................paLV+Wpu.hs....pcs.TWEs..tc.slppp.....p...lptatpp	..........................................l-cll...spc........htctpt.......................................pYhVKWcu..as.............pcs..TWEs...cc..plptt.......ph...lpta..........................	1	1222	1720	2571
+1551	PF01393	Chromo_shadow		Chromo shadow domain	Bateman A	anon	Medline:95396576	Domain	This domain is distantly related to Pfam:PF00385. This domain is always found in association with a chromo domain.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.74	0.72	-4.13	8	489	2012-10-02 16:56:36	2003-04-07 12:59:11	14	9	177	24	286	474	0	56.80	49	28.14	CHANGED	RGLEPE+IIGATDSs.....G-LMFLMKWKsoDEADLV.AKEANhKCPQlVIuFYEERLTWHS	.......................RGL-PE+IlG.A.T.Do.s..............G-..L..h..FLhKW.KssD....c...AD..LVsA+pANhKCPQl.VIpFYEE.RLoW+........	0	69	99	194
+1552	PF00878	CIMR	CIMR_repeat;	Cation-independent mannose-6-phosphate receptor repeat	Bateman A	anon	Pfam-B_764 (release 3.0)	Family	The cation-independent mannose-6-phosphate receptor contains 15 copies of a repeat.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.17	0.71	-4.43	12	1464	2012-10-02 14:19:21	2003-04-07 12:59:11	13	33	108	57	767	1357	0	136.00	23	77.56	CHANGED	shpcsosIpFhCNcssh.s...sPVFhtEs......sCoYaFEWcTthACs...hpslpCplpDstu.pcYDLSuLo+tsc...sWcAVDsots.t.++pFaINVC+....hstspuCP.ssuusChVsc.spShNLGhhtpuPpht.sGslpLpYssGDhCs	....................................th...hsohIpFhCsps..s....u.............pP.h.h.h...p..ps..........sCpahFpWpTshA.C...............s...................p..........sh..............s................Cp...l.........p.......c....s.p.......t....p.p.aDLo...s.Ls...ptpt.............s.a.s..h.....ss....t......tt........................t...ahlNl.Ct...............................s......t.....s.....t.....s....C.....s....ts...u.....usC........h......p..........t.......s..........p..........s..........h..........s......l......G.h.....h...p.....p....t...............ph.....ss............l....l.Y..sGp.C........................................................................................	0	238	267	463
+1553	PF02464	CinA		Competence-damaged protein	Mian N, Bateman A	anon	Pfam-B_2197 (release 5.4)	Family	CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some  stage in the process of transformation [1]. This Pfam family  consists of putative competence-damaged proteins from the  cin operon.	20.90	20.90	20.90	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.55	0.71	-4.77	102	4443	2009-09-13 17:09:44	2003-04-07 12:59:11	12	14	3786	2	995	3093	2194	153.50	36	58.87	CHANGED	tpsLsptlsphL.tppsholusAESCTGGhluutLTslsGuSshFpGGhVsYoscsKpplLGVspphLppaGAVScpsAptMApGs.pptht.....uDhulu.lTGlAGPs.GuotpKPVGpValuluttst.......stsp.chpFsG.sRpp..lRppusptALphLhchL	................h.pLsptlsphL..ppcshslusAESCTGGhlAusloslsGu.SshFcsGhVT.Y.Ss.cs.KtphLuVs...t...p...sLp...p....a...G..A..VSc.tsAtpMAp.GA..h.pt.s.p....................uD..hulu.lTGl..AG..P...s......G.............u............s....c...t+.......PV......G.T.Vah.uhu.....tpss.................shs....p..p.h..........p..a.......s..........G.....s......Rpp..lRppusthALphLhp...................................................	1	323	652	857
+1554	PF04162	Gyro_capsid	Circo_coat; 	Gyrovirus capsid protein (VP1)	Bateman A	anon	Pfam-B_1772 (release 7.3)	Family	Gyroviruses are small circular single stranded viruses. This family includes the VP1 protein from the chicken anaemia virus which is the viral capsid protein.	25.00	25.00	95.40	95.30	21.30	17.40	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.74	0.70	-6.24	22	315	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	11	0	0	241	0	348.00	94	99.88	CHANGED	MARRARRPRGRFYAFRRGRWHHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKlGGPIAGELIADGSKSQAAENWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGpQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITuTTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMuAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDAWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGoQP	.MAR.RARRPRGRFYAFRRGRWHHLKRLRRR.Y....KFRHRRRQRYRR.....RAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGlIFLTEGLILPKNSTAGGYADHhYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSp...SQAAp....NWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPV..ASLLSQGEYLTRRDDV.KYSSDHQNRWRKGcQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITsTTsQGTQV.....R.........CMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMsAPASElDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDuWAVVRVQSVWQLGNRQRP................................	0	0	0	0
+1555	PF02443	Circo_capsid	Circo_ORF2; 	Circovirus capsid protein	Bateman A	anon	Pfam-B_1890 (release 5.4)	Family	Circoviruses are small circular single stranded viruses.  This family is the capsid protein from viruses such as porcine circovirus [1] and beak and feather disease virus Swiss:Q9YUC8. These proteins are about 220 amino acids long.	25.00	25.00	25.00	30.20	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-4.99	12	1556	2012-10-04 01:49:40	2003-04-07 12:59:11	10	1	51	1	0	1258	0	196.30	62	95.87	CHANGED	phphRRRhtRs......hhRRRahRt......RhR.RRh.hpRRtapsNRlYshRlsRpaphplp.ptoss.ushpWssDhlshsLsDFL.ss........................sssshpLPFEcYRI+LAKhEh+Pths.hs.p.cGhGpTslIpDu+lpcFpppsshs.DPLAsaDGA+pW..p+GF.KRLh+PKPQl..oIsDhssu.NpoAALWLsss+shWIPl.....p.hs.suts+VcHYGlAaSa.pP.tss.....hsYpsplTlYVpFRQFsh	..............................R.R.RhtR...........hhRRR.hhh......RY..R.hR..R+.................N.tIashRLp.RTFGYTlK...pTTVpTPSWAVDMMRFNIsDFLPPG.......................GGoNPhSlPFEYYRIRKVKVEFWPCSPITQ.....GDRGVGS.oAV..ILDDNFV..TKATAL....TYDPYVNYSSRHTIsQPF.S.YHSRYFTPKPV.LDpTIDYFQPN.NKRNQL.WLRLQTs........................sNVDHVG.LGT....AFENS..hc......pYshclThYVQFRpFs...............................................	0	0	0	0
+1558	PF04487	CITED		CITED	Finn RD	anon	Pfam-B_3987 (release 7.5)	Family	CITED, CBP/p300-interacting transactivator with ED-rich tail,  are characterised by a conserved 32-amino acid sequence at  the C-terminus. CITED proteins do not bind DNA directly  and are thought to function as transcriptional co-activators [1]. 	21.10	21.10	24.90	21.80	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.69	0.70	-4.11	11	168	2009-09-11 10:42:53	2003-04-07 12:59:11	7	2	46	2	72	157	0	163.30	35	97.93	CHANGED	MA-H.MhAhsauhhssshtt......hphsMs.....u.stps.+s......hps....uslhHYuuu...uhcuuhtsRsu...........sG.shuhupPsus..s.hhas........................ss.p.p.Fh.....ssuspLhASMpLQKLNopY.G+............tsts......sGtPhssus.Q...aR........sGsu.ssuhpp..ss..hs.ulhDsDhIDEEVLhSLVlELGLDRlpELPELaLGQNEFDFhoDFsst.tsupVSC	........................................Msph.h.shsht.hsts.tt......hp.t.Ms...th.s.sp.ht.pt........hps....sthhHYsus...shpu.s.t.p.ts...................u.s.sh.s....P.t.t.............................................s......a......t.s.pL.ASMpLQKLNspY.sh................................................hts.....sup.htsss.p.................t................................................u.......s.sssh.t...................shhDsD.lDEEVLhSLVlEhGLDR....hpELPELaLGQNEF.DFhsDhss............................	0	6	14	28
+1559	PF04223	CitF		Citrate lyase, alpha subunit (CitF)	Mifsud W	anon	COG3051	Family	In citrate-utilising prokaryotes, citrate lyase EC:4.1.3.6 cleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits. The gamma subunit serves as an acyl carrier protein (ACP), and has a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group. The citrate lyase is active only if this prosthetic group is acetylated; this acetylation is catalysed by an acetate:SH-citrate lyase ligase. The alpha subunit substitutes citryl for the acetyl group to form citryl-S-ACP. The beta subunit completes the reaction by cleaving the citryl to yield oxaloacetate and (regenerated) acetyl-S-ACP. This family represents the alpha subunit EC:2.8.3.10.	19.50	19.50	19.50	19.60	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.52	0.70	-5.82	5	1131	2012-10-04 00:26:15	2003-04-07 12:59:11	7	4	925	4	116	1121	28	448.90	64	91.35	CHANGED	DRKLsuSLEEAIc+oGLKDGMTISFHHAFRGGDalVNMVM-lIA-MGFKNLTLASSSLossH.sPLVEHIKNGVVT+IYSSGLRGsLA-sIS+GLLcEPVpIHSHGGRVHLIpSGEL+IDVAFLGVPsCDEFGNANGacGKAsCGSLGYAhVDA-YADpVVhLTEsLVsYPNsPASIsQDQVDhVVpVDAVGDPsKIGuGATRMTTNPRELLIA+pAA-VIsNSGYFK-GFShQTGTGGASLAVTRFL+EKMl+cNI+AoFALGGITAoMVDLHEcGLI-KLLDVQsFDSsAApSLARNPNHlEISANpYANPuSKGAuVDRLDVVILSALEIDTpFNVNVlTGSDGVIRGASGGHCDTAuAApLSIIVAPLVRGRIPTVV-cVsTVITPGoSVDVLVTDpGIAVNPsRPDLl-+Lpcss.lPVaoIEpLpERActlTGKPcPIEFTDKVVAlV+YRDGSlIDVV+QV	............................................................................................................................................................................................+KlsuSLEEAI++SGLcDGMTlSFHHAFRuGDhslNhVM-.hIA.cMGaKNLTLASSSLsssH.sP.LlEHI+sGVVopIYTSGLR.G.LuEpIS..c..G.LLt.pPVpIHSHGGRV+LlpSGELpIDVAFLGVPoCDEFGN..AN..G......h....s....G....K....u....sCG.SLGYAhVDAc.AcpVVhLTEpLlPYPp.sP.ASIsQDQVDhlVpVDc.VGD..ssKIuuGATRhToNPRELLIA+pAA-VIspSGYFK-GFShQTGTGGASLAVTRFLc-KM...cp+sIpAsFALGGITuoMVDLHEcGLI.......+.........KL...L.D..V......Qs.........FDp.sAAp..SLAcN.P.s...H...l...E...I..SAN.....p.Y........A........N.........uSKGAuV-..+LD.V.V.lL.S.A.L.EIDT..pF..NV.N..V..l.TGSDGV.lR.GASGGHsDTAhu.ut.....L.....S.......I....I.l..A..P..L..V..R..G.R.IPTlV-...pV...h...T.slT.PGuSVDlLVTD+GI.....A....VNPs...R...s...-LhEpLp.p.AG..l.lho..IE.L+-RAphLT.G.cPp..P..IEF.T.D...R...VVAVV+YRDGSVIDVV+QV..............................................................	2	32	62	87
+1560	PF01874	CitG		ATP:dephospho-CoA triphosphoribosyl transferase 	Bott M, Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The citG gene is found in a gene cluster with citrate lyase subunits [1].  The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase [2-3].	20.80	20.80	22.20	21.10	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.47	0.70	-5.20	135	1741	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	1304	3	316	1196	72	248.10	35	85.49	CHANGED	pl....uphAhpAhhhElsh.PKPGLVchtssGuH.DMshtpFhp.Suhultshhtphspsuht...t..........ltplGhpAEpsMhtsTsGlNTH+GulahlGlLssAsut................................h.tttsstsstthhtslsthssshh.....t..............t........tpshohGpththpauhsGsptEstsGFstlhphulPthppsh..t................hs.ppAhlpshltlhuph.sDTsll+RuGhpsl.phlpppAppl....Lstu.............t.tt..hpplpph-pthh..pcslSPGGoADLLusolFlst	..............................................................................h....huhpAhlhElploPKPGLVDthssGAH.p.DMslt.sFhp.Suhult.sah.phhphGhptsth.........................hhttlR.lG..htsEtsMhpATsGlN..T...H+GuIFulGLLsuAhut..............................................hht..t.p.shs...pplspth.sp.hs.pslst................................h.tp.....ttphTtGpphhpphGls.....Gs....RGEApuGashVhptALPhhpphh..pp...............................ths.chAllpsLLh.LMuh..sDTNlhpR.u.G...t..uL..pa.lQp.pAppl....LtpG.................Gh.hs.ss.....hptLpphDcthl..c+s..lSPGGoADLLhhThFls.p............................................	0	62	165	244
+1561	PF03600	CitMHS		Citrate transporter	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Family	\N	29.60	29.60	29.60	29.60	29.50	29.50	hmmbuild  -o /dev/null --hand HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.34	0.70	-5.87	32	7280	2012-10-02 15:12:49	2003-04-07 12:59:11	11	35	3249	0	1836	11155	2469	359.10	15	84.92	CHANGED	Luhhhslshhh..llhhpthuslhuhhllsllhsLh..............................hs.hh.phlshls..slhLLFuhha.hslM.-oGlFDslsphlhchspGc.hclhhsssllsullShsGsusTsshlss.shhl.Lacphsls.hhlssslsluuslhs.hsPhGsPss........ps.hsslsh...sshhsshlPuhlsulhhhh...hhhhhhth+cppthtthph.htt..............................................................................................................................................................................tpshtptpsptttht+shlhhhshhLshslhshl.............................lhuh............h.s.lhhhhuhslsllhsa.slcpphp...th.ttstsshsslhhhhAhhlFsullstsuhhctluptlhsl............lstslu.hlsllsuls.ShPhshhhu.ps....hhslhhpsusthGls.h.hshsuslGs	.......................................................................................................................h..h.h.h.......h..h.......................h.....s....h....h...h...h..h....h..h..h..s..h.hh.shh..........................................................h...h..t..p....h...h....s...t...h....s...............s.............l..........h...h..l........h...u..h..h....h...st.h...h.p.p...o.Gh...hp...hls....p...h...l...l....p....h..s.....t......s......p......................p.........l...h..h...h...l......h......l.........h...s...u..l..l..o.s.h.h......s...s.s...s.....s...s...h........l.....h....l.....P..l...s............l.......s....l...........t.............p..............p...........h...............p...........h.............s..........s.................t..............h...............h...h..h....s....l....s.....h......u..u........s..h....u.u.h.....h....T.......l...G...s...P..s.....s...h..h.l........................................ts...hts.h.s...h.................s...s....h.....h......t...h.....h....h....s...h........h...l...h...s...h..hh...hh.........hhh.h.hh.h.pp.tt.t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...h.t.h.h..h....h..........h...h..l...h....h...s.h..h.hhh.....................................................hht.h.........................................h.....h...h....h....h...u.....h...h....h.....h.......h........h............h............t........h.................t........h.......p....p...ht.............................................t.....ht.h............hl...h...h.h...h....u.h.....h.h.h...s..t....s....l...t.......t.....h...s........h..h.t.....h..h...s.p.....h.h..th......................h.......h...h..h.................h..h....s..t....h...h..........s.......s..hh.h.....................................................................................................................................................................................................................................................................................................................................................................................................	0	639	1190	1535
+1562	PF00285	Citrate_synt	citrate_synt; 	Citrate synthase	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.30	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.20	0.70	-5.72	121	9392	2009-01-15 18:05:59	2003-04-07 12:59:11	16	26	5081	103	2244	7278	4274	289.30	36	82.11	CHANGED	GL.....psshsspopIohlDG...........ppGh..LhYRGYsIp-Ls.p.pss.............FEEss.aLLlhGc..L.PspppLppFppplttpp.t..........lsp...plh...phlps.hPp.sscPMshLpsulusLus.hp.t..........tstph...p..hcpuhcL.lAphPslsAhh..a+hp......pGtphltPcss..Lua...utNFLhMl..pspt............s.s.....t.hscsh-hhLlLaADH.thNuSTFssRlluSThuDhYuulsAuluuLpGPLHGGANptVhchlpcI....ss...........scpscpalcctlsp.pc..+...lMGFGHRVY+.shDPRApll+chscplstph.........sp....sphhclupplEchshp...h.p+.t...lhPNVDFYSullapth.GlPt..-hFTslFAluRssGWhAHhhEp....h.t.....ss+l.hRP	.......................................................................h.sh.sh.otls.lst...........pts.....LhaRG.hsl.pLs.p..tsp..............................a.-sh.aLLh....G.c...........h.P.s.t.t.p.h...tt.hpttltt....t..............l....t...t.h..........thhtt...h......t....HPMs.h.h.sshsh.lssh......................................................t...tt.....shcl.h....up..hsslh..shh...a.+ht.........................s....h..h......s...p..ts......hshstp.F.lh..hh....h..stt................s..h.cshchhhh.La....A-H..t..............N.s............S.T.T..s...Rl...............s...u.S...............o.t.u.s..a.u.slsuuluu.L...hGPh.HG.G.A.N.Essl.c.MLpcl............ss.....................scpl.ca....l.t.+.t.h.cc....p-........+...................lM..GFGH.RV.....Y...+...shDP..RApl..h+chsc.clhpch..........ts....s..s..lhc.lAhc..lEclshp.......hhc+.+.......LaPN.........VD..........FaSGl....h....h.............ct.h..........G..............h.Pp....p........h..a..............T..............s..............l.FshuRhsGahAphhE.....ht.....t.tl..RP.....................................................................................................	0	694	1359	1866
+1563	PF03802	CitX		Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase	Bateman A	anon	Bateman A	Family	\N	25.00	25.00	26.40	25.60	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.94	0.71	-4.82	29	1055	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	904	0	101	514	3	165.80	43	81.99	CHANGED	pslsL.plLsuREtRsshQpphLpca.pt..sLlSlTlshPGslKsssthcplFstulpslpphhtptthhhhtp....sttTGPEuhhslsts.AtplKphhltlEcsaPLGRLaDlDVl...sspsptlSRpsluh..ssR+CLlCscsA+hCuRuR+HulpElhsplpchlpph..spc	...............................p.sVolsElLsuR-cRtARQ+th....L..p+a..ss...........PLlShTlssPGslKsStlh++lFspulsslpsLstcps.W.phpt.p...............th....lspsoG...PEuhl.uls.uP..Aps..LKtthlpLEcsHPLGRLWDIDVl.............ss-G...chLSRc....-huL..P.sR+CLlCpp.s.AtlCARu+pHsLs-Lls+hctllpshpt.s..........................	0	23	50	75
+1564	PF01214	CK_II_beta		Casein kinase II regulatory subunit	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.10	20.10	22.20	21.10	20.00	17.30	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.35	0.71	-4.78	66	783	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	323	22	504	729	15	179.10	47	69.13	CHANGED	sWIshFssh.hspcaFscV-c-aIpDpFNLhGLppp..lspappALchILDhpstp..................................pthppsp....tptl-psAptLYGLIHARaIlTspGlpt.....Mh-KYpp.ucFGpCPRlhCpsptlLP..lGlSDtsspssVKlYCPpCpDlYpP..ssctsslDGAaFGsoFPphFlhsa.sc..hhspt........................................................................ppahP....+laGF+	..............................................pWIsWFCuh.cG.sEaFCE..VD--YIpDcF.NLs..........GLspp...V.s.h.Yc.............pAL-hILDlps..pp.......................................................t..s.....p.p.......pphl.EpuAchLYGLIHARYIl.T.s+Gltt..M.........h-KYpp.u-.....FG.pCPRVaCp....spshLP........lG...hS.DhP.....sps.sVKlYCP+C.....pDlYhP..po.s..+.....p...tp...l............DGAaFGToFPphhhhsaPp....hhspp.........................................................................................stppahP....+laGF+...........................................	1	212	307	426
+1566	PF03805	CLAG		Cytoadherence-linked asexual protein	Lawson D, Bateman A	anon	Lawson D	Family	Clag (cytoadherence linked asexual gene) is a malaria surface protein which has been shown to be involved in the binding of Plasmodium falciparum infected erythrocytes to host endothelial cells, a process termed cytoadherence. The cytoadherence phenomenon is associated with the sequestration of infected erythrocytes in the blood vessels of the brain, cerebral malaria. Clag is a multi-gene family in Plasmodium falciparum with at least 9 members identified to date.  Orthologous proteins in the rodent malaria species Plasmodium chabaudi (Lawson D Unpubl. obs.) suggest that the gene family is found in other malaria species and may play a more generic role in cytoadherence.	18.30	18.30	19.90	19.80	16.80	16.70	hmmbuild  -o /dev/null HMM SEED	1282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.23	0.70	-14.21	0.70	-7.22	10	213	2009-09-11 00:22:49	2003-04-07 12:59:11	8	2	15	0	39	216	0	436.10	45	84.97	CHANGED	DNIpELKphI-N-ELYcNLspLE+hlLpoLEpDKLKlPlhps-s+.cYlDhSpFKll...cstssucscsYIlPThcoohcDIIKYEHlLKpQlhpcYss-ISDhIK+KlLlVRTLKllKlMLlPhNsYKcssDlKpALpELNclFpsc..ppppcccsslphpschFcpllpsl+tlKcppph.pth......DsKp-lh-hsDhFFTTssNIEFM-sLDpIoNpYGIGlaNhlGsHhIALGHFlsLKLALKpYcpYFEtGslKFaoWQKILpFshSDRFKlLDLMCDcsusYcsppKRRpoYLKscpouoopECNILEFLIHaFNKYQlELlppspcp-FslahhhEHKclK-cFFsFMCs..csKECsIYcospFKpEps--ssFs-pps.sFs........hhuPaNlYsNYaYFhKpYs-FsscpllYlHlLNLsGlLNs-scAYVoSLYLPGYYNAIQLSFp--ppLs-LapNLlKClcKCau.p++spo..p+.pslpsptcp-sSKCslCKGsFhYIN.Ks--ssSMLQKFYsYlTKlLclpplSoLlcshsIY--YsNFLoHDLNWYTFLFLFRlTSYK-IsppoVuEAMYLNLKDEDsh++ThVTsaWYPSslKKaYTLYlRK+lusNLL-ELEpLl+pcTIEKMKKSIpFllHVNSFLQLDFFHtLNEsPlG..RsaPLShlLEs+FK-Wh.shssGFaFlNYDcPptRtcLacKhcsp+FlsPKhscWschLK+lIcsAY-hYFpQRHVKNLaKaHssaNINNKIMLMRDSYELYhKNacDllFhADIhllRKYLouTPKl++lpDRhaYalHslhGNulNFYKYGlIYGFplNKchLKEVV-ELaoIYphNpcIFoDlSFLQTVYLLFRKIEpSatSHRRNDclSlNNIFFhNVusNYSKLsKEER.pEIHsSMASRFauKThFosFQhMFsopIS+clD+LDKhYGKAshlplsssEcAaLpFAYlY.GSIhDSlTNsLhPhYAKKPIsQLKYGKTFIhANYFhLuSplauhLNLNNLShLCEYQAIsSANaYShKKluQFls+KFlPllsYahhhRlts.hspsp...ttaphhpt.us.sp........................hhhpsshYhohYhusNLah-sstaFPssLssELp-QT-alptpp.ccKPslHuhspshlhullpuhshsFslaslspaYAFF-NllFalhsshRFhDRaaslhspYhssah+phh++hTsDllLKhhp+sYpshKKcGYYcEsIsARLssKpplpphltt-pspslhsslp.h-hcshp+.shshYsD-phhF-DlscNEpFLN-R	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................shhpFAYhYsGSIMD.SlTNsLLPPYAKKPITQLKYG+TFVFSNYFMLASphY-MLNYKNLSLLCEYQAVsSANaYSuKKlsQFlGRKahPlTThaLhhRIptohsahp......thphhs..ss............................................hts-sshaLaFaFFhNLYhDuhKaFPGGFusuL+EQTcH.Vppps.....a.+KP.VHths........................................................................................................................................................................................................................	2	14	17	38
+1567	PF01217	Clat_adaptor_s	Clathrin_adapt_s;	Clathrin adaptor complex small chain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.74	0.71	-4.47	7	3187	2012-10-04 00:47:01	2003-04-07 12:59:11	15	38	357	27	2033	2739	18	135.90	25	49.99	CHANGED	hl+hlLlhs+pGchRLsKaY.sshssscc.pKhlcclhtslosRpsch................sNhlEhps..h+llY+pYAsLYFshsl-.s.-sELhhL-lIppFVEsLDphFs.NVCELDllFNFpclahll-Ehl.G.G.lhEoshppllcplt.hspht	..................................................................................hphlhl.h.s.ppGc.h.....hls+hY....t................s...............h...............s......p.....p..........p..........p......p....p....h...h....p...c..h.h....p...h.h.....h......s.+....t..t..p..h.......................................ss.h...l.......p......h......p......s........hph..lY..+.+...............a.s.......sL.a..hsss....s.......s.....ps.s.N.t.L.h...h..........l..-...hlp............p.h.l.-s..l...sc.a..F.........t........s.....l.s.Eh...s.l.h...N.a....h........la...l...........LDEh..l...s...G..h..h................p.Ts.p.lht.h......t..................................................	0	669	1072	1604
+1568	PF00637	Clathrin	Clathrin_repeat; 	Region in Clathrin and VPS	Bateman A	anon	Prosite	Family	Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.47	0.71	-4.59	150	4251	2012-10-11 20:00:59	2003-04-07 12:59:11	15	79	397	51	2715	4128	33	136.90	16	33.12	CHANGED	l.php..shhshspllchhpc...tshhp.lhtaLpphh......s.pt..ppsslpstLhphhhct......sp.pplcphlp..phsp.....aDhtpluphs..ccpc.Lhptthh...lYpc..hsphpchhp...l.hpp.pthppsh..chstctss.....clhppllphhlsptphph	..............................................................h........phppllp...hh.p.......ts..h...h..p.t....Lh..taLpthh....................t...p...........pp.tslpstLhthhhct....................................pp.pplccalp................t.sp.........ach..tp......l.t.phs.......pc....tp...h....hptthh....lapc..........hsphpphlp.......h..hpp......p.....phppsh........ch.ht.c..h...ss....................p...hh.plhth.hp......h.............................................	0	886	1499	2201
+1569	PF01086	Clathrin_lg_ch		Clathrin light chain	Finn RD, Bateman A	anon	Prosite	Family	\N	20.40	20.40	20.50	20.60	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.84	0.70	-4.43	28	493	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	297	6	289	500	3	200.20	27	86.99	CHANGED	MA..DcFPsl-s.sss........s.h..ssptsssu-FLuREcshLGD...pFto-pD.......hs.s-sD.................p.ssFppsFPslsststt.....sussushsGshht.s.......suhsphsphpsE..PEsl+cWRE++ctcIpc+-ctsccp+pEhhcKApccIDDFYpsYNpKp-KppupsR..................t-tE....pFLucR--h.opsGTpWERlAcLlDhssKus+...su+D+oRFRclLlsLKtptpAPGu	............................................................................................................................................................s.........tstFL.tp..ppt..lus..................h.ps..................tss...............................................................t....st..ts.t........................t..ts.s...sut....t..s..........................t.....su..h.....s.t.h...s....p..ppE.....sEslR...cWREcpptcL..p...c..+....Dtppc...........cpctEhhccApccl--.aYpphscph-+s+t.sNR....................................tpE-......tFlppp-c....t.sGo...p..WERlAcLs.....D.....h.ss+ss+............................pspDhSRhRplLlpLK.....psPh...................................................	1	94	157	232
+1570	PF01394	Clathrin_propel		Clathrin propeller repeat	Bateman A	anon	[1]	Repeat	Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles.  The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure.  Each leg contains one heavy and one light chain.  The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller [1].	21.30	21.30	21.90	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.35	0.73	-7.82	0.73	-3.30	71	581	2012-10-11 20:00:59	2003-04-07 12:59:11	15	30	177	39	344	507	4	38.40	30	4.84	CHANGED	sshspphsa.ssh..shhhlhslp.........stuplhlhslc	.....tsst.IsacssscpphhhlhGls.........ststGphplhsV-..	0	90	164	246
+1571	PF03505	Clenterotox		Clostridium enterotoxin	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	32.40	35.10	21.90	16.80	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.18	0.71	-4.92	4	72	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	20	25	4	63	0	172.20	44	58.07	CHANGED	D+DLIGTLLIEusoSGSIIQPRLRNTTcPlFsoSNsTtFSQpYTEtRLcDAFNIpLFNTSTsLFKFVEEAPsNKNIshKsYNTYEKYELIcYpNGsIsscApYYLPSLGasEVosAPSstu.VVch.lspsuFIQsGPpEcIVlGVIsPSENIp.EIsTsIu-sYTYNIPshlssNPhYlLFsVNoTshYKIoscsNL	....................pllGs.lIpsuooG.lhp.pLRsospslhhs.ssspFspEYhcsplpssF.Nhp.hNp.shhFcFscpAPSNKNlhhhl..TY.+YElIch.pssIs-+A.hYlPSLGYscshphsS.tt......lsps...............................................................................................................................	0	2	4	4
+1572	PF03515	Cloacin		Colicin-like bacteriocin tRNase domain	Griffiths-Jones SR	anon	PRINTS	Family	The C-terminal region of colicin-like bacteriocins is either a pore-forming or an endonuclease-like domain. Cloacin and Pyocins have similar structures and activities to the colicins from E coli and the klebicins from Klebsiella spp. Colicins E5 and D cleave the anticodon loops of distinct tRNAs of Escherichia coli both in vivo and in vitro [1]. The full-length molecule has an N-terminal translocation domain and a middle, double alpha-helical region which is receptor-binding [2].	25.00	25.00	37.00	31.60	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.86	0.70	-5.19	8	84	2012-10-01 19:36:59	2003-04-07 12:59:11	9	10	43	12	4	97	0	272.40	34	49.83	CHANGED	Mu......................................psG.sausp.ssa.shtt.s.............GGsspsG..uuoshu.s...................s.hPtshAh.......GlPuhhsPG.......sG........shulSlsus....slsAAlu-lhtsL+G.....stP.....................aKhshsGlulhulhPupIAcDc.sh.................hshlVooLPsDslT-sPlSsLPhspssVsVshRlsDlVcDspQplAlVsu..hPhsVPVVcA+P........TcpssVaoAul.PG.hPslplSVspssssspuhscuhssc......cstsspPAGaThGuso+..-AlIcFPccSGpcP.lYlSVoclLosspl...KQRQ-EEp+tppcWc	................................................G..........s..spG.sausp.ssasshtt.s.............GGsspsG..GuSuhussh...................hsstshAh........h.ulhhPG............tG........GhuVolpus....tlSAAhssl.suL+G...........s.P..........................huVuhhtl.Puphsc.pc.hh........................lhso..h-plT-hPsS..pLPhstssVsVphRlsDhspstpQhhullsG....hP.M.oVPVVDAhP........TphssVaoAsl.Ps.hPsL.lSVsptsssspsss.h.pps.......pstshh.AGaThuuNs+..DsllRFPcsSGhsP.lYlSss-lLssspl...pQRQ-tENptppca...........................................................	0	2	2	4
+1573	PF03513	Cloacin_immun		Cloacin immunity protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	27.90	59.60	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.67	0.72	-3.94	6	22	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	17	7	6	26	1	80.50	54	72.32	CHANGED	GLKLcLsWFDKKTE-FhGcEYSKDFGDDGSVIESLGlPLKDNINNGsFDVccsWVPlLQPaFKNpI-hDKahYpISFDYRDu	..GLKL+LpWFDK+TE-FpGcEYScDhGDDGSVIEpLGhPlcDN.INNGsFDVpppWlslLQPaFpppI-hs+apY.lSFDYRDt...	0	0	2	5
+1574	PF01785	Closter_coat		Closterovirus coat protein	Bashton M, Bateman A	anon	Pfam-B_1309 (release 4.2) & Pfam-B_6985 (release 8.0)	Family	This family consist of coat proteins from closteroviruses a member of the closteroviridae.  The viral coat protein encapsulates and protects the viral genome. Both the large cp1 and smaller cp2 coat protein originate from the same primary transcript [1].  Members of the closteroviridae include Sugar beet  yellow virus and Grapevine leafroll-associated virus,  closteroviruses have a positive strand ssRNA genome with no DNA  stage during replication. 	21.30	21.30	22.20	21.60	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.18	0.71	-5.25	11	1326	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	50	0	0	1130	0	171.40	35	75.75	CHANGED	hshpshs.sssspLssc-h+plhtphppplpsch.........sss--chhhtluhhLhphushSTSsKlsh..psstoh...shs.scchslpcu.lhshlpuph.htspsNsLRsauRoaEctYlshspthhpt.sptptsuK+GlPuthpYLuADFlsGosstho-c-pAshLhApcsALc+p.usts-pplssLppLG+h	......................................................t.....hh.s.s.lshs-h+.l.sp..thlspch.........shss+-ht..ha.luhhlhplsspSoShpscc.sssshoa....spt..Gh..c..hcls-chhhshlhss.hsh.s..s.psNsLRhauRop-shalshs+ps+sl.s.sttshctGlPst.aaYLsADFLsGu..slo..-.h-pu.sh...l.A+cphLc++tu..cps.lhNlpph................................................	1	0	0	0
+1575	PF00574	CLP_protease		Clp protease	Bateman A	anon	Prosite	Domain	The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111, his-136 and asp-185 form the catalytic triad. Swiss:P48254 has lost all of these active site residues and is therefore inactive. Swiss:P42379 contains two large insertions, Swiss:P42380 contains one large insertion.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.82	0.71	-4.62	86	9058	2012-10-02 13:07:06	2003-04-07 12:59:11	18	23	5278	397	2138	7738	4927	176.10	39	75.01	CHANGED	spuE...cshD.lYuR.LL+-RIIFLustl.sDphAstllA.QLLaL-u-sssK-IhlYINSPGGsVoAGhAIYDTMpal.+scVsTlCh.GhAASMGuhLLuuGspGK..RhuLP.suRlMIHQP...hGGspG..QAoDIpIpAcElh+l+cplsclhuc+.T.GpshEcIpc......Dh-RDhaMoA..pEAh-YGLlDpVlppp	.................................................................t........hD.l.as.R.L.hc.-Rl..l.hL......s....s.......t...l..pD..p..h..A...s.......l.lA.Q.LL..a.L......-....u.p...ssp......KD.Ih.lY...I.N.S....P.......G.............G.........s.........V..........oA..............G.........h..............AI...Y....D...T...M..........p.....a....l.......+......s.............c......V..s....T....l.....s..h.....G....h....A....A..SM...G............uh...LL.s............u.GscG..K..Rhs...LP.....su........c......l......MI...H...Q...........P................h...G...G..h..pG.........QA....oD.......l....p........I..p..A.c....c.l...h.+........h+...c........p.......l.......s.....c.....l.h.uc+...T....G..p.......s.......h...E.......p.......Ipc...........................Dh...-........R.D.....p....a..h.o..A........pEAh-YG...llDplhp..p...............................................................................................................	1	751	1443	1838
+1576	PF01093	Clusterin		Clusterin	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.30	20.30	19.90	18.70	hmmbuild  --amino -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.51	0.70	-5.68	14	180	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	48	0	59	144	0	339.10	37	92.73	CHANGED	ppLpphSptGp+Yl-cElcNAlpGVKpMKolME+opEEHppLhpsLEcsKccKE-ALKhsp-sEp+LcEcpclCNETMhuLWEECKPCL+pTCh+FYo+sC+SGuGLVG+QlEEFLNpoSPFhhhhNG-clcsL..h-psppQshplsplE-sFoplsssV-pLFp-Sh.hatphp..FspshpssFh.....hpPhhhsthptthttsc.....pth..p..Ph..hp.hsh.shFQ.Fh-huhphhpuhssthpp.ht.........t.u.phs.sp.hh....sDRtlC+ElR+NSoGCL+h+-cC-KCp-IL.ul.DCotppPspspL+pElp-uLpLAEchoppYsplLp.hQp+M.NTouLL-phscQFGWVSpLANhTps.scshFploTVso+ss...sspuPuD.TpV.sVplFsSsshTlslPt-lSh-sPcFh-hVApcALQ+aKpch+pt	..................................................pLpphS.ttGpphlscElppAl.GlKphKphh-+spc-+ppLhpsLccs.+ccKp-...Alp.hp-spt+Lpc..plCptohh.s...W-EC+sCLcpsCh+aYs.sCpsu.u.VtpplEp.Fhpp.s..shhh.........hp...t-phcsL.........pp.pppst.ls..thp-tFs.phs.s.hspLFpcp..........aspt..shah.......s.....h..hp.....h..t........p.............t.hs..h..shFp.hh.ph.hph.pshs...hhpp....................s....p..h.s...p..h...t....psRhlC+ElR+NootCh+h+ppCpKCpphL.th..DC....Ps.stL+pchp-ulplsph.sppYsplLp.hQt+h.sTs.LLcphpcQFuWVSp.LAN.Tts...sp.hhpltpVh...s+...p....s..s...........s.ts.T.V.slplhsSssholplP.-.shpsspFhphVstcALppa+pp....................................................................................................	0	4	8	23
+1577	PF03026	CM1		Influenza C virus M1 protein	Griffiths-Jones SR	anon	Pfam-B_1290 (release 6.4)	Family	This family represents the matrix 1 protein of influenza C virus. The protein is the product of a spliced mRNA. Small quantities of the unspliced mRNA are found in the cell additionally encoding the M2 protein (see Pfam:PF03021).	20.20	20.20	22.60	276.40	18.30	18.20	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.48	0.70	-5.26	2	132	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	89	0	0	34	0	218.90	100	86.56	CHANGED	MAHEILIAETEAFLKNVAPETRTsIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPsDYTPDIRIGTITAWLRCKNKKSERYRSNVSESGRTALKIHEVRKASTAhNEIAGITGLGEEALSLQRQTESLAILCNHTFGSNIMRPHLEKAIKGVEGRVGE	MAHEILIAETEAFLKNVAPETRTAIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPDDYTPDIRIGTITAWLRCKNKKSERYRSNVSESGRTALKIHEVRKASTAMNEIAGITGLGEEALSLQRQTESLAILCNHTFGSNIMRPHLEKAIKGVEGRVGE	2	0	0	0
+1578	PF03021	CM2		Influenza C virus M2 protein	Griffiths-Jones SR	anon	Pfam-B_1092 (release 6.4)	Family	Influenza C virus M1 protein is encoded by a spliced mRNA.  The unspliced mRNA is also found in small quantities and can encode  the protein represented by this family.	20.90	20.90	22.80	308.20	20.00	18.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.77	0.71	-4.63	2	111	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	87	0	0	38	0	139.00	98	70.10	CHANGED	MGRMAMKWLVVhIYFSIASpPASACNLKTCLpLFNNTDAVTVHCFNENQGYMLTLASLGLGIITMLYLLVKIIIELVNGFVLGRWERWCGDIKTTIMPEIDSMEKDIALSRERLDLGEDAPDETDNSPIPFSNDGVFEI	MGRMAMKWLVVIIYFSITSQPASACNLKTCLNLFNNTDAVTVHCFNENQGYMLTLASLGLGIITMLYLLVKIIIELVNGFVLGRWERWCGDIKTTIMPEIDSMEKDIALSRERLDLGEDAPDETDNSPIPFSNDGIFEI	0	0	0	0
+1579	PF02543	CmcH_NodU		Carbamoyltransferase	Bashton M, Bateman A	anon	Pfam-B_1740 (release 5.4)	Family	This family consists of NodU from Rhizobium and CmcH from Nocardia lactamdurans.  NodU a Rhizobium nodulation protein involved in the synthesis of nodulation factors has 6-O-carbamoyltransferase-like activity [1].  CmcH is involved in cephamycin (antibiotic) biosynthesis and has 3-hydroxymethylcephem carbamoyltransferase activity [2], EC:2.1.3.7 catalysing the reaction: Carbamoyl phosphate + 3-hydroxymethylceph-3-EM-4-carboxylate <=> phosphate + 3-carbamoyloxymethylcephem.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.06	0.70	-5.33	11	743	2012-10-02 23:34:14	2003-04-07 12:59:11	10	5	526	10	274	1274	3956	344.30	32	61.74	CHANGED	sSAashSsFtpu..lslslDusGDhhsphhhluptsthth..hspFPtp.....t.......lGhha..hphsphhGashh.stGKlMuLuuYG.sssphhsslpphhchpttss........Ycthlsthpsslhcshchh....ct....h..ppcpcluAohphhlE+llhchhphhhtchs...hsp.LslAGGsuhNlphNutLhppGhFsclaV.PtssDuGsAlGAAlhshsphst......hPhchs..VY.GPshss-.......p.csssWcuphp.......hhuplAshLAsGclVuahQGRhEhGPRALGNRSILA-PpsscsKD+lNthl+.REtFRPaAPosLEEcss-hF-.spsc...PaMhhshpsREsh....................tcplPAlsHlDGoARlQ	...........................................................................................................uAahsSsFpcs....sllslD.G....h...G.....-.......h.....s........o.s.........hh...h.tc.s.s.p....h....p....h.....h...t...ph.thPpS.............................................LG.hhY.........tthTtalGF....p....h................p.......sEh....K.lM.G.LA.sYG......t...s.......t...h.....h..h..p...h...h.....pp.hh..p...h.p.s.ss........................................ah.t.....h..s.h....h....p....hh.....t....t..h..h.t....hh...................t........t......t.....ptt....hDl........A...suhQt.hh.Ec.ll...l....ch...hcth...hppts......pp..LshAGGVALN...s....sh...Ns....+...l....h....p....p......s......F.c.........c..............l..a..V...p..P...A..u...u...DuGs.AlGAAhhsht.phts......................................t.ht.p......sYL..GP.sas..sp...............tht.h.th.hts.....t.h.t.h............p.....p..tlhp.p.sAphL.Ap.u.p....lVuWaQGR..hEFGPRALGsRSILusPpssphpcplNthlK.REpFRPFAPslLtEcuscaF..c..h.s..p..su.....................Pa......MhhshpVp.tp.h..................................+scl.PAVsH.l.DGTARlQ....................................................	0	93	169	217
+1580	PF04989	CmcI		Cephalosporin hydroxylase	Bateman A	anon	COG3510	Family	Members of this family are about 220 amino acids long. The CmcI protein Swiss:O85726 is presumed to represent the cephalosporin-7--hydroxylase [1]. However this has not been experimentally verified. 	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.08	0.70	-5.01	31	285	2012-10-10 17:06:42	2003-04-07 12:59:11	7	8	264	36	73	634	456	186.70	38	79.54	CHANGED	tpasasapWhGhPIlphPpDlhshQEllacl+PDlIIEoGlA+GGShlahAuhLpll...............tsct+VluIDI-lRtpsptul-s.+sh.pRIphlpGSSscscllppl+phtpt.hcpllVlLDSsHopcHVLsELch.YusLlosGsYhlVhDTll-chsts....h.s.......psWs.GsNPhsAlppaLppps............c...FplDp...thps+hh...lTsuPsGaL+Rs	......................................h....hphpahG..hshhp.stDhh..h.QE.l.l..ac.l..+...P.cL...IIEhGstaG.G.Ss.lahAs.hLchl.................................sps.+Vls..l..DI........s...h..p..s......s........t..h..p..t......................s..R.......Ip.h.l...p......u.SS.ss..s..p.h....lpplpp.h.tp..sshl..llILDSsHop.pHVhtELph.Ytsll.os.GsYhlVEDT...s...l..s.s...hPh.....................sa..G.s.G..PhpAlcpaLtpps............p...FhlDp....hcpKhh...hohsPpGaL++......................................................................................................	0	24	52	57
+1581	PF02627	CMD		Carboxymuconolactone decarboxylase family	Mian N, Bateman A	anon	COG0599	Family	Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway [1]. In these bifunctional proteins (e.g. Swiss:O67982) CMD represents the C-terminal domain, Pfam:PF00561 represents the  N-terminal domain. 	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.77	0.72	-4.14	215	9489	2012-10-01 19:19:04	2003-04-07 12:59:11	15	45	3396	115	3044	7828	1802	82.90	18	51.31	CHANGED	Pphhphhtphttshhh...putLsh+p+cLlslusshsps.sshsh...shHhpt..Ah.psGsop...ccltcshth.tshhs....uhstth..suhthspp	...............................h.phh.thhhs.hh.....pu.....Lshpp+cLlsl.ss...u.t.ss.....s...s.shsl........phH...spt....uh...p....t...G....hop............cc..l..t.plh.th...tsh.ht.......th...stth..tuhthh...........................................	0	764	1817	2496
+1582	PF00795	CN_hydrolase	Nitrilase;	Carbon-nitrogen hydrolase	Bateman A	anon	Pfam-B_1042 (release 2.1) & Pfam-B_5155 (Release 7.5)	Family	This family contains hydrolases that break carbon-nitrogen bonds [1].  The family includes: Nitrilase EC:3.5.5.1 Swiss:Q42965, Aliphatic amidase EC:3.5.1.4 Swiss:Q01360, Biotidinase EC:3.5.1.12 Swiss:P43251, Beta-ureidopropionase EC:3.5.1.6 Swiss:Q03248.  Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.21	0.71	-4.94	58	15146	2009-09-13 06:29:50	2003-04-07 12:59:11	17	49	4520	101	4901	12501	4878	178.50	18	46.69	CHANGED	psAssQ........hs....shhshpss.htphhphl..............................tcAsct..usp.llshPE...hhlsua................ht.thtphhthuh................sh......u.thptlt...........................................................................phApppslhllsG.hspp......csst.....hYNshlhlsss.....Gphl..........s.pYRKh+........h.tah.....EpphhstG.........stsh.ssass......s.h....u+lGh..hI.........CaE..hhaPthtph.hst.............pGspllsssss	........................................................................................................................................................................................................................................................................................................thhQ........h...........hh.s....h.t...t....s....h.....tphh.p....hh....................................................ppA.spt.........ssp...lllhP.E........hh.h..s.sa..............................................................................p...h.....t...h.s..t................................................sh....................t.h.h..pt.l..p...................................................................................................................................................................................................................................................................p..h..A.....p...p....h...s.....h...h...l.l...s....G....hs.p...........................pssp..............................ha....N.sh.h..l...ls.ss..............G.plh.......................................s...pYc....K.h.HL....................h.....tah....................Ep...t.h.hs.sG....................stth....s.hpt...............................................h...................h...+....l.uh......hI...............................................CaD...........hh.a..P.p.h......h..p..t..h.s.h................tG..spllhh.t.....................................................................................................	0	1561	3031	4091
+1584	PF01110	CNTF		Ciliary neurotrophic factor	Bateman A	anon	Sarah Teichmann	Domain	\N	19.30	19.30	19.80	19.30	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.37	0.71	-5.02	2	48	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	34	4	26	265	0	175.60	49	95.14	CHANGED	MAhs-.oP.sshR+.DLCSRuIhLARKhRSDlTsLh-.YVc+QGLstsIslsusDGhPsAus-pWuE.TtspRL.-NLtAYRsF+sLLAphLE-Qp.hhssT-u-ht.AltshLLQVuAFsYplEELh.L.phthP.sEtsu.P.ssschuLFEpKLhGL+VLpELuQWsVRSl+DLR.lSpH..G.PupGuthhhsppp	....................................................MAhs-..s.ssp++.-...LCS....RSIhLARKhRSDlTsLh-sYscpQG..........L.....sp.s...l.sl..s..u....hD..GVP..sA...o..s..-..p..WSEhT-u.ERLp-NLpAYRsFcshLspl......LE-Qcsph.sPs-u-a+pAI+...sllLQVuAFAYplEELMh.L.L..ph.plP....s.Ess..uhPh...s.s...G..c..t..GLFEKKLaGL+VLpELuQWTVRSl+DLRllSpp.t.G..hsu.tst..........................	2	1	3	9
+1585	PF03450	CO_deh_flav_C		CO dehydrogenase flavoprotein C-terminal domain	Griffiths-Jones SR	anon	SCOP	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.07	0.72	-4.08	168	4331	2009-09-11 23:20:01	2003-04-07 12:59:11	12	53	1952	108	1331	3679	1203	98.20	24	19.57	CHANGED	pua...Khu+Rts.DluhVsuAhtlplp...s..........st...plpss+luhGGhuss.sh+A.ppsEphLhGpshsp.pslptAhpslt.p-hsPhsc.hcuospYRpplutsLhhRhhhps	............................................................t.ta.KhucRps...shu.lVssAht..lphc.....s.....................................s......hlp.ps.RlAhG.......GsAs.............p..sh.Rs...ppsE...pt..L...........h...........G...........p...........s....h..........s............t....p....s..........l....p...p........A.sp.........t.hh...ps..........h.........t....sh...ss.......t..u..ps...t.......Y.Rhtlstshhh+hh.t.h......................................	0	410	752	1046
+1586	PF00473	CRF		Corticotropin-releasing factor family	Finn RD	anon	Prosite	Family	\N	22.10	22.10	22.20	26.60	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.80	0.72	-3.87	7	187	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	111	8	64	192	0	39.40	47	25.30	CHANGED	tPSlSIshshclLRphL.hchscpphpphp.....sNRphLspl	....PPlSlDLTFHLLRphLEhuRAcp..tp.QAc.............pNRplh-.l...	0	11	19	37
+1587	PF02552	CO_dh		CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit	Bashton M, Bateman A	anon	COGs	Family	This family consists of Carbon monoxide dehydrogenase I/II beta subunit  EC:1.2.99.2 and acetyl-CoA synthase epsilon subunit.  Carbon monoxide beta subunit catalyses the reaction: CO + H2O + acceptor <=> CO2 + reduced  acceptor.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.87	0.71	-4.70	6	97	2012-10-03 09:55:27	2003-04-07 12:59:11	11	5	65	5	55	244	219	163.80	27	75.46	CHANGED	tphphhP......p.ssl.sscpAshhps.cssspMI++AKRPlLllGPplhpsE.hEtpsKthhc+clshltTu.....h..tsl...cchp..shh-hophlpssp.phh.hpGpaDLslFlGshhYasupsLstLKpFosplpslsIscaaHPsAchSFsNlsc--..ahchLpEhl	................................................sh.....P........tshhtschsphhps.chuuphlppAKpPhlhsGshll..h..s......h.ps.h......t.....p.......tht.h.t..plshstsu.......ht.hsh...c....cs...+Y....shhp.ps.lsssc.phh.hcsp..hDhslFlGlphaaus.sLphl+sao..sshphshhschhH.sAph..Shsshs.t-.c..hht.hltp..h....................................................................................	2	14	34	44
+1588	PF01121	CoaE	UPF0038;	Dephospho-CoA kinase	Finn RD, Bateman A	anon	Prosite	Family	This family catalyses the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form Coenzyme A EC:2.7.1.24. This enzyme uses ATP in its reaction.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.99	0.71	-4.88	13	4826	2012-10-05 12:31:08	2003-04-07 12:59:11	15	23	4560	31	1266	3845	2571	176.30	33	80.94	CHANGED	hllGLTGGIGSGKSTlushFsp.hGlsllDADllARpVVpPGssuLspIsccFG...ssllhs-..GpLcRpALtcclFucsEc+phLNullHPhIppchhcpluphps...saslhslPLLhEs.phpslsspVlVVcss.cpQlcRshpRc.ulocpcspuhlsAQhSccERluhADsVl-Npushs-	...................................h.llGLTGGIuSGKSTV....u....p....h....h........p................p....h.....G...h.sl............l...D.AD..h..l........A..........+.p..l....l....p............s.Gs...........s.hp.t...l....h....p.t..F.G..................s.p.l...l........t.......t......c..........G..........p.............L........sR.....t...t.L.up.h......lF....s....s....s....p..........p....+....p....h...L..........ssl.........l.........H......P..h....l....p.p....c....h...t........c...p.........h...............p.....p....h.......p.p.t..................sh.l..lh.-.l.....PL.L..h.E...........s.....s..........h...p..............p.....h............s.....c...c..V...l.V..Vt.s.s...c.h.............QlpRlh............pR..............c......sh..o...........c....-.cspthls......uQ.hs......hcp.+.h..th....A.....D....hVI-Nsut...p.....................................................................................................................	0	433	796	1062
+1589	PF02035	Coagulin		Coagulin	Mian N, Bateman A	anon	IPR000275	Domain	\N	25.00	25.00	25.40	341.10	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.33	0.71	-4.59	2	4	2012-10-02 16:54:34	2003-04-07 12:59:11	10	1	4	2	0	10	0	173.00	78	93.51	CHANGED	sNsPhCLC-EPslLGRp.IVopEhKDKIEcAVpAlspcstlSGRGFSIFutHPsF+ECGKYECRTVpsEcSRCYNF.PFpHF..ECPVSspsCEPsFGYTsusEhRlIVQAP+AGFRQCVWQHKCR.aGSN.CthsGRCTQQRSVVRLVTYsLEKssFhCEshRTCCGCPCRS.	TNAPlCLCDEPGlLGRpplVosEsK-KIEKAVEAVAcEuGVSGRGFSlFSHHPVFRECGKYECRTVRPEHSRCYNFPPFhHFpSECPVSTRDCEPVFGYTsAGEFRVIVQAPRAGFRQCVWQHKCR.YGSNsCGasGRCTQQRSVVRLVTYNLEKsGFLCEoFRTCCGCPCRS..	0	0	0	0
+1590	PF04733	Coatomer_E		Coatomer epsilon subunit	Mifsud W	anon	Pfam-B_3343 (release 7.5)	Family	This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.62	0.70	-5.22	7	430	2012-10-11 20:00:59	2003-04-07 12:59:11	9	22	320	7	259	625	124	243.90	29	86.34	CHANGED	tsDcLFslRN.FYlGuYQssINpup.lsshst-ss.E+DshlaRuYlAlGphtlVlsEIctus.ussLQAV+hlA.ahssstp+-thlupLpEhlucpshssNsshpLlAullah+-psas-AL+th+tu.ssLEhhALsVQIhlKhcRh-hAcppL+hMQpIDEDtTLTQLAsAWlslAsGG.pKlp-AahIFp-hu-Kas.TshlLNGpAVsshthtpa-EAEolLhEALsKDspDsETLhNLlVsshclGKs...ssR.lSQLKhsHPpHshVcchsppEspFDRhspphs	.................................................................t....Lhsl+staahGtYptsl.php...h...t.........s...s...p.t......t....hptphhhhRuhlA...t...p.....ht....ll.....tpl.....tt..ps.....s...st.......Lt.......Al....p.hh..A........p..a...h...t.....s................p....p...........ct.h......l.t....p....lp.................p...h....sp...p.........................ts.......h....h.......lhsu...l...h.h..t..ptp.p...tA...Lph..l.......p.........p.............t.......s.............s............l.....E.....h..h..A.........h.....h..l.....Q.....l...h.L...p....hsRh......Dh.A....p........+...p......l...pt...h.....p....p..h......s......-................D......s..h......Lsp.....LApuW..l....slthGu.....-p..........h.....p.pAaa.....lap.E.....h.....u.....p...p..h.....s.........s......o....................h.l.....Ls..upAsspht..schp-A...c...s...h...Lp.......p......A.....L.....p....p....c............s...p....p......s.-......s......l..h.N.h.l...lhs..h.h.GKs...ss..ch..h.s................p...L.p..t.....s.p.p....Hs....hlpc...ht.ttpt.F-phs.ph.t.........................................................................	0	98	151	219
+1591	PF04053	Coatomer_WDAD		Coatomer WD associated region 	Wood V, Finn RD	anon	Pfam-B_1269 (release 7.3);	Family	This region is composed of WD40 repeats.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.47	0.70	-5.69	60	828	2012-10-05 17:30:42	2003-04-07 12:59:11	9	37	318	6	577	840	14	397.60	33	41.01	CHANGED	psplpphshpsp.........ssphhslshKchGssphh......PpoluasP...ss+hlhV......susGcYhlYo.............ulshpspshGpuhshlWsu...pNc..aAlh-p.spslcl..KNh.cpps.hslplshss-plFs.....GsLLslpssu..lshYDhpptpllpclc.ls...s...KhVhWSss.Gp.hVAll...............o..........ccohhlls.hsh-..............................shsslpE...s.plKSutWss.s..VhlYTTts...+lpY..hlsG-sshIppl-pshYllthhs...s+lYhlD.+-hplhuhplsss.lcFppullcpch-p............................t.spll............tpplspaLpppGa.ElALphspDscpRF-LAlphGsLclAh-hAcphs....spp..........pWcpLGctALppGshplAcpsap+sp..caspLhhLYhsoGstppLp+luphApppuchsstFpsthhh.GclcpplclLhpouphs.AhhhApoau.	.......................................................................................................................................................................................................l.phshpt............tp.h...lsh.+chG..s..s...h......Ppolpa...sP......stchVlV..............sssGpY.lYo..........................uhshps.pp.h.Gpu.p.hlasu.....psc.....aAlh-p...s.p............p...........lpl...KNh..ppph.......s....l.p..s..s..h.....s.s.-.t.Iah..............G..LLhhp.s.ss...........l..shaDhpp.t.p.............h..ltclc..ls........K.VhWS..ss..up.hVulh....................s........cc.shhlhp.hph-....................................................th.psl..pE...s.pl+oGhWs.......s....s....sFlYoots...+lpY..hss.G........-hshltpL.D....p......s......hY.l....h........thhs.............s...plYhhD.+-hpshsh.s.ls.o.hca.phulhcpch-..p....................................t.spll..............tpplhpaLppp..Ga..EhALphs.p...............D....c.pRF-LALphGpLc..lAhc......hA.pphs...........spp...............................................pWcpLuchALtpsshplsc.sap+sc..saspL.hLahsoGs.t..ptLp+hs.ch.Actpsc...h.................sstF.shhhl.Gcl....cppl.clLhpss..phs.AhhhApoat.......................................................	0	228	341	487
+1592	PF02572	CobA_CobO_BtuR		ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	Bashton M, Bateman A	anon	COGs	Family	This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis.  These enzymes catalyse the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.	23.40	23.40	23.70	26.20	23.20	22.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.93	0.71	-4.63	173	2528	2012-10-05 12:31:08	2003-04-07 12:59:11	10	9	2106	4	629	1797	875	170.90	42	88.83	CHANGED	pc+GlllVaTGsGKGKSTAAhGhshRAlG+Gh.......+VuVlQFlKG.s.hps....GEcphh.cph.......ss..........lpacthGc.GFTWc..opccp.pD..htsAppuWptAcphlt.................sspaclVlLDElshsLca......salsl-cVlssLp.sRPttpcVllTGRsA.sptLl-hADhVTEMp.lKHsFcs.Gl+AQpGlEa	........................c+GlllVaTGsG..KGKoT.AA.FGhuhRAlG....+Gh.......+VuVlQFlKG....phps......GEcshL.c.th..u......................Vca.p.s..h.Gp...GF..oWc..sps.cp...pD..............tssupps...W.pc.u..+.chLt..........................s.s..phDhVlLDElshslpa......sa..Lsl-EVlp.s.L.p.....p.R.Pt..p.....pcVllTGRss..ppl.l-hADhVoEhc..lKHsFcs..Gl+..AQtGI-a........................	0	192	403	529
+1593	PF01122	Cobalamin_bind		Eukaryotic cobalamin-binding protein	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	26.80	26.50	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.04	0.70	-5.82	11	162	2012-10-03 02:33:51	2003-04-07 12:59:11	14	7	67	16	90	185	0	281.40	30	67.51	CHANGED	hhhLssLLhhuusssthtp.CplspspppLlcsL.ppLLpshsppuu.s.NPSlhluLRLuuhpshstEphhlppLKhphppp.huSsou........p.ohGpLALhlLALpuuCcshu........cs.cLlopLccphEsEpctht.sHputPtTsYYQhSLulLALClcpscsspsVss+Lhpslp+s.hhhsuphSVDTtAMAsLALTClcpphhs.......shcsplshAlcslhEKIlppppssGhhGNlYSTsLAlQtL.sosp..sc.thsCtKshsslLsplppGsFpNPhuhuQlLPuLptKTYLDl.p.ssCsuscss..hh.....Psssosspsp	..............................................................................hhh...hh........p.C.......lst.pt.hlp.l...hh......p.....sPSlhluhpLus....s.ph...pp....h..h.ppL...........hts..s..........................t.shGpL..ALhlLALpusCcsst........hs.cLlupLpcphppttpth....sppstPhosaYphuLulLALChpstcspt.phls+Lhpshpts....tsp...hS..V.DTtAMAsLALsClppsthp........t.tpplstslcplhccIhppp.ps.pGhhG..NlaSTuLAhQ.AL.sss.....t...........sc.thsCtpshssl.Lp.p.l.p.pGtFpssh..huQlLPsL.tKoYlDl.t..pC.s.p.....h......P................................................	0	14	19	39
+1594	PF03186	CobD_Cbib		CobD/Cbib protein	Mifsud W, Bateman A	anon	Pfam-B_2468 (release 6.5)	Family	This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein [1]. This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate [1].	28.00	28.00	28.00	28.40	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.72	0.70	-5.34	139	2167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1937	0	647	1878	476	282.10	30	91.11	CHANGED	hhhlhlAllLDhllG-.Ptth......HPVshhG+llshl.-pthppt..........tp+htGhl..hhhhllsssshluh.hlhths.................hlshll.ps...hllhssluh+oLtccuttV.....tpsL.pps.sLstARctluh.l...VuRDTspLscstls+AslESlAENhsDGllAPLFahh........l.....h........GhP......G..uhsY+slNTLDSMlGY+s........c+YppFGasuARhDDllNalPARLTullhs.lsuhhh............tu........h....phhh...+Dutpa.SPNuGas.AAhAGALulpLuGsshY..G.h...cshlG..suhpsssst.cIppAlpLhttss	.........................................h..hhhhuhllDh.llG-..P..th.............HP...V.h...h..hGp.hhshl.-...phhpp..........................ttpht.G.s..l.hh.llh.l.s.sshhlsh.hlhhls.................h.t.hhs.hhhpshhlahsLuh+uLtcpsptl......................tpsL.........p.....p.......s.....Dlst........A.....R.ptluh.l...VuR.DTspL.st.stlsRAslE.olAENssDullAPLFahh..............l.u........................G.sP..............u....s..hhY+sl.....NTL........DuMl......GY.+.s...........p.+Yp.....tFG........h..suA......+.lDDlhNalP.ARLou.lhhs.lsu...h.h..............................pu...................................hchhh.....+-st.....pasSP.Nu.G.h.sE..AAhAGALulpLGGsshY..h.....G.ph....+P.hlG..ss.....p.t...s.st...cltpulpLhhh..s...................................................	0	190	410	540
+1595	PF02654	CobS		Cobalamin-5-phosphate synthase	Bashton M, Bateman A	anon	COG0368	Family	This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyses the synthesis of AdoCbl-5'-p from AdoCbi-GDP  and alpha-ribazole-5'-P [1].  This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop  assembly stage in conjunction with CobC, CobU and CobT [1].	21.70	21.70	21.80	21.70	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.34	0.70	-4.78	8	2349	2009-09-13 21:11:09	2003-04-07 12:59:11	10	4	2268	0	598	1783	441	235.20	29	94.17	CHANGED	l+uhluFhTpLPlhu......DhEphpctlhtaPllGhllGslsulsthltshhhs..s.LsuhLslhlhlhhsGhhHlDGLADhuDGlhusss+cRhltsM+DhplGsuGlsslllVhLlphhuLtpls..h.hhhlhluplsAKhshlLshtht+P...ttpGhGuaFhcphcp.pplslGhllhlllslhhu...sh..h.slhAlhsulhsulhluphuc+pFGGloGDVlGAusElocssoLLuL	.........................h...slsFhT..R..l..PlPt...........ths.h.....p......p...h...s....+..u......h...h....h......a.P.l.l.Gl.ll...G.s...l...s.....u.hl..h...h.l....h.t..h...h..h.s...............s..l....u.u.l..l.s.l.h.s.h.h....llTGuhHlDGLADosDGl.h.u......s.t........s......+.............-R......h.....LcIM..+DSR....lGsa....Gsl....A...L...l.h...s...l...L.....h......+....h......h....s....l...s......p....L......s..............t.............s...........t.................h...........h...........h..............h.........h......l..........u...s...s.......s....u.....p....h....s...s......h....h...s....h...h..h..h.h.......................s+tpG.h.G.....s...h...h...h.....s.p........h.s...t.......p...p....h.......h...h....s..h....h......h...s...h....h...hs...h...h.hh........................s........h..t.s....l.h.u....h...l......s.....s.....h......l..........s...h..h....h...h....s....p....h....h.t+....cl....G.G.hTGDslGA...s...h...clsElshLls.................................................	1	189	397	511
+1596	PF02283	CobU	COBU; 	Cobinamide kinase / cobinamide phosphate guanyltransferase	Mian N, Bateman A	anon	Pfam-B_7022 (release 5.2)	Domain	This family is composed of a group of bifunctional cobalamin  biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.98	0.71	-4.84	192	2330	2012-10-05 12:31:08	2003-04-07 12:59:11	11	13	2134	6	530	1759	319	165.20	37	82.22	CHANGED	hLVoGGARSGKSpaAEpLs.....hphs....tps.hYlATupsh....Ds....EMppRItpH+pcR...sspWpTlEp....s..h...cLsp.sL..tp.tst......pslLlDCLTlWloNllht.p.........................p...shptphppLlssl...pp.hssslllVoNEVGhGlVPpssluRtFRDhhGplNQplAstAccVhLlluGlPl....pl	.................................................hLlhGGARSGKSpaAEplh.........................tp............tpl..hYlATuphh........Ds......EM..ttRIt.pHppp....R.........ssp...Wp...Tl...Ep......h...................cLsp.hl............pt....ttt.............tpslLlDClThaloNllht.s...............................tp..slp.tcl.pp.L...lsul......pp.....ps.u...p.l.llVoNEVGh.GlVP.tsp.lu.R.pFRDhtGclNQtlAstA-cVhlVVuGlslp..................................	1	172	358	453
+1597	PF00241	Cofilin_ADF	cofilin_ADF; 	Cofilin/tropomyosin-type actin-binding protein	Chris Ponting, Joerg Schultz, Peer Bork, Finn RD	anon	Prosite; SMART;	Domain	Severs actin filaments and binds to actin monomers.	21.10	21.10	21.20	21.10	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.70	0.71	-4.25	16	2431	2012-10-01 21:06:05	2003-04-07 12:59:11	15	42	403	61	1450	2235	7	121.70	20	53.52	CHANGED	ssspssap-l+tscp...hphllapIscs..ppplhVc......p........ss...tssssa--........Fhppls.....tp-scYulaDhchp.........suphsKlhFltWs.PDs..A.l+pKMhYAS.oKssl+ptLsu...lphplQuo..Dhs-ls.c-tltp+hp	.................................................................t.......h.pht...t.t.....hphl...lhplptp......pppl..hlp............p.............h.........ssshc.c.......................h.h.p.p.Ls............psp.s...p....Y......sl.a.c..h.ch.pt....................ssp.h.s.c.h.l.h.l.h.Ws..P.-.s...........u.....s...l.+pK...MlYAo..s+....ss...l...p.c..t...l.ps.........hph..pl.p.us......s.p-ls....p.l.t...t................................	1	449	733	1114
+1598	PF00963	Cohesin		Cohesin domain	Bateman A	anon	Sarah Teichmann	Domain	Cohesin domains interact with a complementary domain, termed the dockerin domain.  The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1].	21.40	21.40	21.50	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.32	40	1118	2012-10-01 21:34:18	2003-04-07 12:59:11	13	97	144	45	199	1131	188	151.00	25	40.86	CHANGED	lplslssssu.psGssVsVPVslssl.ss...lushshslsYDsslLphssspsGs..............llh..sssssFsss.tsssuhlshh..Fhcso.husphIspD.GlhAslsFKVpssssss.............sslshssshsasssshsplsssh.ssGslsV	..........................lplslucssA.csG..sphsV..sVolucl...Pss....Glpsh.sFslpYDs.slLpl..sslp......sGs.h................................................hh.s.ss...u........sh........a.p...s...s.....p.s..s..cG.h..lshh....aosss.tsuu.h..hl.ps-..Gl..FsTIsh....pVsusss.sGs.........................s.lp.h...................................................h................................................................................................	0	105	188	196
+1599	PF01410	COLFI		Fibrillar collagen C-terminal domain	Ponting CP, Schultz J, Bork P	anon	Pfam-B_464 (release 3.0)	Family	Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.	26.80	26.80	26.80	27.10	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.73	0.70	-4.92	36	1510	2012-10-01 23:56:02	2003-04-07 12:59:11	13	94	127	0	533	1087	7	167.00	40	15.57	CHANGED	l+sPpG.o+csPARTC+DLphsHP-....hpsGpYWIDPNpGsst.DAI+VaC..shps..GETClhPs...spl.ppsWappps....ttsWFupphpGs.................pFsYsss..........slQlsFLRLLSspApQNlTYHC+NSlAahDpts.sshc+AlhLtGuNDhElps-sssphpYpVl.pDGCpp+supauKTVlEa..cTp+spRLPIlDlAPhDlGsscQcFGl-lGPVCF	.........................................................ppP.G.opcsPARoCcD.Lphs..a..P....c....h..s....GpYW.lDPN.p.G.Cs..Du.h+VaC..Nhps....G-....T.Clh.sp......tt.h...tta...tt...............ahu........h....t..t......................hpYss.......s....hlQh.sFL+LLSspApQslTYpCpsohu.a..h..-.....t..........ts....s.s.h.c...pu.lhh.G..u........N..-..................E...h.p.h..c..........sp.h.......h.......p........s.h.....DuCp.......p...p..Gt....t.cTlh-h..pT........psppLPllDlt.....Dh.G.ts.s..p.c..aG..h-lGPVCF.................................................................	0	127	171	312
+1600	PF01024	Colicin		Colicin pore forming domain	Bateman A	anon	Bateman A	Domain	\N	23.40	23.40	23.40	29.80	21.20	23.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.98	0.71	-4.71	14	176	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	93	7	11	176	0	170.20	39	38.52	CHANGED	pcppcpsEpphlpcAs-hhsuhhcclsEphGcKacplA+-lAsshK...GKpIRSh--AhuShpKhtsN.shKhstsDR-AIsNAhculshp-hAppLsplSKuFKhsshshpstclhpchhcuhcTGNWtPLhlclEohslushAouVshhlFShslG..........sslGllGI.llsulluuhID-shlsplNphl	...............ptppptE.phlpDAlchsssFhcplsEcaGtKhpplAcElAspu+...GKpI+ss..-.....-ALpua-Ka+s.slsK...KhstpDRtAIspAL-ulphpch....upplspFuKuhthsu+shphhDlhs-hhcuhcTsNW+PlFlclEshssusuA....oslsuhh.FSlhhG...........oslGIlGh.ullhusluAhID-phl-plNchl.............	0	1	3	8
+1601	PF03857	Colicin_im		Colicin immunity protein	Finn RD	anon	DOMO:DM07441;	Family	Colicin immunity proteins are plasmid-encoded proteins necessary for protecting the cell against colicins. Colicins are toxins released by bacteria during times of stress [1].	25.00	25.00	27.20	29.20	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.73	0.71	-4.43	4	38	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	0	3	37	0	130.20	56	79.78	CHANGED	cshlLcpIhspsp.LPSITShaNPlMTclMslYsKTAPhhAllLFIhTaKpRcLIpposRptVL+SChhuslhYAshlYlhhFpNhELTTAG+sh+LhspN.ssTLhlhYhulYhhIhahoYhsLhsPlhshKhhKtRQ	....aSpVLYhLY.NKlu.LPSITSLasPlMTpLMSsYsKTAPVhGILlFLCTYKTREIIKPl....o.RKL...VlQSCF..WGPVFYA.ILI..YITLFYNLELTTAGu.FFKLlS+N.slTLFILYsoIYaoVL.TMTYAl....LLhPlLVhKhFKsRQ..............	0	0	1	2
+1602	PF01320	Colicin_Pyocin		Colicin immunity protein / pyocin immunity protein	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	20.90	20.90	21.10	21.80	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.82	0.72	-4.12	29	341	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	189	47	44	217	1	84.90	43	95.53	CHANGED	Mc.hKp..plpDYTEsEFLpFlpclhps...p..hss--....hspLlcHFpclTEHPsGoDLIaYPps...st-DSPEGllcplKcWRAuNG+PGFKp	...............hKpplpDYTEpEFlEhlpclhss..p.........ps--........hhDsLlcHFp.+.l.TpHPssSDLIaYPpp...pt--pPEsIlchlKEWRtppGhPhFKp....................	1	3	11	21
+1603	PF02674	Colicin_V		Colicin V production protein	Mian N, Bateman A	anon	COG1286	Family	Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30 [1]. This protein is coded for in the purF operon. 	25.80	25.80	26.00	25.80	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.05	0.71	-4.35	164	3878	2012-10-03 02:02:08	2003-04-07 12:59:11	11	7	3737	0	790	2303	1930	149.10	22	74.52	CHANGED	lDllllhllhhuslhGhhRGhlpplhulhuhlsuhhlAhhats.lushlst.......................................stthtthlua.hl...lFlhshll.stlluhhlsp.....hl.ph..ssluh.hD+lhGslhGhl+uhlllh.lllhlhshhshst.............................hhppShlhs.hlt......shss	........................................................lDhlllhllshu.slhGhhRG....hltp...........h...........luLl..uhls...........uhhlAt.t...a.h.s..l.us.h.l.st...............................................................................t.s...phht.s...sluh...hl...lFl...hs...h...ll....stllshhlsp...........ll..pt.....ssLut....hDR....l....lG.s....l....h.G....slcuh....lllh.llh.h...lh...s.h.h.s.hsp.............p.................hppShlh..hh.....s...........................................................	0	259	520	663
+1604	PF01114	Colipase		Colipase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports duplication of common fold with Colipase  C-terminal domain.	19.40	19.40	19.60	24.90	19.10	17.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.14	0.72	-4.47	9	50	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	36	7	28	47	0	39.20	63	37.13	CHANGED	PRGllINLEsGELClNSAQCKSpCCQHsosLuLARCs.KA	........PRGlIINL-sGELClNSAQCKSp.CCp+souLuLARCssKA....	0	3	3	7
+1605	PF00325	Crp	crp; 	Bacterial regulatory proteins, crp family	Finn RD	anon	Prosite	Domain	\N	20.50	14.00	20.50	14.20	20.40	13.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-7.03	0.72	-4.47	12	2310	2012-10-04 14:01:12	2003-04-07 12:59:11	15	6	1382	67	409	4399	727	31.70	52	13.95	CHANGED	Lsho..Rp-IAcaLGhThETVSRhls+LpcpuLI	..........lphT..Rp-I.GphlG.h.o.hETVuRlLpphpcpsll.............	0	79	197	303
+1606	PF02740	Colipase_C		Colipase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports duplication of common fold with Colipase  N-terminal domain.	23.70	23.70	24.60	23.80	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.38	0.72	-4.21	5	53	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	32	7	26	45	0	44.20	69	42.92	CHANGED	ENSECSPpTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGIChD	........ENSECSsc.TLYGlYYKCPCERGLTCEuDK.oIVGoITNTNaGlChD................	0	2	2	4
+1607	PF03047	ComC		COMC family	Mifsud W	anon	Pfam-B_2107 (release 6.4)	Family	This family consists exclusively of streptococcal competence stimulating peptide precursors, which are generally up to 50 amino acid residues long. In all the members of this family, the leader sequence is cleaved after two conserved glycine residues; thus the leader sequence is of the double- glycine type [2]. Competence stimulating peptides (CSP) are small (less than 25 amino acid residues) cationic peptides. The N-terminal amino acid residue is negatively charged, either glutamate or aspartate. The C-terminal end is positively charged. The third residue is also positively charged: a highly conserved arginine [2]. A few COMC proteins and their precursors (not included in this family) do not fully follow the above description. In particular: the leader sequence in the CSP precursor from Streptococcus sanguis NCTC 7863 Swiss:O33758 is not of the double-glycine type; the CSP from Streptococcus gordonii NCTC 3165 Swiss:O33645 does not have a negatively charged N-terminus residue and has a lysine instead of arginine at the third position.  Functionally, CSP act as pheromones, stimulating competence for genetic transformation in streptococci. In streptococci, the (CSP mediated) competence response requires exponential cell growth at a critical density, a relatively simple requirement when compared to the stationary-phase requirement of Haemophilus, or the late-logarithmic- phase of Bacillus [1]. All bacteria induced to competence by a particular CSP are said to belong to the same pherotype, because each CSP is recognised by a specific receptor (the signalling domain of a histidine kinase ComD). Pherotypes are not necessarily species-specific. In addition, an organism may change pherotype. There are two possible mechanisms for pherotype switching: horizontal gene transfer, and accumulation of point mutations. The biological significance of pherotypes and pherotype switching is not definitively determined. Pherotype switching occurs frequently enough in naturally competent streptococci to suggest that it may be an important contributor to genetic exchange between different bacterial species [2]. The family Antibacterial16, streptolysins from group A streptococci, has been merged into this family. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-7.19	0.72	-4.51	20	666	2012-10-02 23:56:30	2003-04-07 12:59:11	9	4	281	3	31	212	0	29.20	45	61.52	CHANGED	MKp.........ppLppFppLs-c-LppIpGGshhtphh	............Mcp........h.pL.ppFppLoscELQcIpGGthh....h......	0	6	10	15
+1608	PF02247	Como_LCP		Large coat protein	Bateman A, Mian N	anon	Pfam-B_2294 (release 5.2)	Domain	This family contains the large coat protein (LCP) [1] of the  comoviridae viral family.	27.10	27.10	27.70	33.70	26.10	27.00	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.04	0.70	-6.06	10	129	2012-10-04 01:49:40	2003-04-07 12:59:11	11	4	22	5	0	137	0	314.50	38	47.63	CHANGED	pE.sLhpLSLDDTSSl+GohLpTKlApo+llLsKsMlGGTlLpsshLsshLscushRAolsLhRTHVIpGKI+slAolNls-NTGCuLAlsaNSGlcGt.huTDIYThsSQDuhlWNPACcKss-aoFNPNPCuDuWshtFLp+T+sH..hsVpCVoGWTsoPhTDltlslsWaIssphCVP+phslusspssFslNRWMGKLoFPQGsspVl+RMPLuIGGGAGsKsAILMNMPNAhlSLaRYF+GDllFElTKMSSPYIKATloFFIAFGslo-chsN...LESFPHKLVQFuElQc+T.TlsFoQpEFLTAWSTQVhssssspuDGCPaLYAllH.DSsoSTIEG-FslGVKLlsI+sasuhGpNPGhpGoRLLGuhu	..............................h...p.uo.h.phlhpshh.lshshssGshlhsthLs..L.spts.htsh.hphhphh.uplhshhshtls.ssGhuLhhsaspG.c.ut.hso..slhphhu.pphhWNPAhp..hph.hpP.sCsDhWshpaLtpspht..hsl.slotWhssPhsDhphohshahps....p.slPc.....ph.sshp.tsshhhp+.hGpLsF.QG.ppshhph.lshGtstsstptlh.shssAhhuh.pYhpuslhh-lhhhSSPhItuThuhhlshG.sh.cphsN...h-uh...PHh.hpFuchpcps.slpFsp-.Fhshhohphhs.sshptDssshhaslhp.DusuSsl.G-hshtlthp..tshphhGhssGh.sshhhh..................................	0	0	0	0
+1609	PF02248	Como_SCP		Small coat protein	Bateman A, Mian N	anon	Pfam-B_2294 (release 5.2)	Domain	This family contains the small coat protein (SCP) [1] of the  comoviridae viral family.	21.90	21.90	23.00	21.90	19.10	18.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.93	10	94	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	21	5	0	104	0	162.30	36	20.83	CHANGED	ssps.sVYsshhhlcTPlss.osppsFuuFThDLlsusISsDuoG.NWshslhsSPIuNLL+TAAWK+GTIHhQLhhpG.AuVKRSDWuuosplsLppuhuscuhsARoWhIocP+uu-lpFslEIsGPNNGFEMhsSsWANQTTWaLEhlIsNP+QhslFElsh+lspNFEVAGNsLhPPlsLS	..................p............................................u.s.shcl.pSPhspLLpssAWh+GTL+aplVhcG.uuschusapspsQlslosspss.pohsup.pa...s...ho..pPtShELpFsh-lsGPssGFc.Mh.s.h.uspp.ahLphtlsNs+p.ssh.l.uthspDhchAGp.........t..........................................	1	0	0	0
+1610	PF01257	2Fe-2S_thioredx	complex1_24kD; Complex1_24kDa;	Thioredoxin-like [2Fe-2S] ferredoxin	Finn RD, Bateman A	anon	Prosite	Family	\N	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.58	0.71	-4.60	178	4533	2012-10-03 14:45:55	2003-04-07 12:59:11	14	41	2679	24	1588	3500	2480	131.40	29	53.12	CHANGED	lcphls+Ys....pppuAllslLphsQcp.......h..G.alstsslphlAchLs..lshhcVhpVATFY.ohFp.....hpPsG+.ahlpVCssosChlp..Gu-clhcshcccLGl..ph.G....cTT....sDGpFoLppVcCLGAC.spAPshhl....sc..........-..hapcL.Ts-plppllcphp	...........................................................h..t.htpa.........t.tushl.hLphhQpt.............G.als.tshthlAchL.t..hs..cl.tVsTFY.s.h...........hp.P.sG.....+.....ahlplC.....su......s........s........C.tl..p...G.u.pp.lh.pt...l.....c...c....c......L.s.l.........p.....s..................p.so................D....G.p....hol.p.ps.p.C.lG.sC.....s....p......u......P..s.hhl......ss......................c....has..p...l.o...s...-.pl.t.cllcph......................................	0	643	1141	1390
+1611	PF00346	Complex1_49kDa	complex1_49Kd; 	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	Finn RD	anon	Prosite	Family	\N	20.40	20.40	22.50	20.50	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.74	0.70	-5.40	7	7353	2009-09-12 08:12:15	2003-04-07 12:59:11	14	22	3508	15	1751	5117	3078	185.50	28	55.80	CHANGED	DlGAhTPhhahFcEREclh-haEtsoGhRhHsA.ahhhhGVtpDLPhGhhDclh-asc.F..tlD-h-chlTpNpIahpRlpGlGhlott-AlsaGhoGsMLRuSGltWDlRKspPY-sY-ph-a-lsh.sttGDCasRYLsRltEMRpSl+IlpQslpphPsGP...pl-th+hp.s.+schppphEslIt..hhho.saplPsG-sYstlEuPKGEhGlYLsuDso.hPaRh+lRsPuFsHLphlsth.+GhhLADlhAllGolDlVhG-VDR	..........................................................................................................................................oshh.ha.p...Rp..h.......phhEhhsG.Rhh.s.h.h.GGl..t.....D.l..............................t....................................h.t.h...h.p...h..t.t.l.t.p.h...p.hh....ts..h..tR........sluhhs.p.A.hthu..sGshhRu.o.....G.h...t.hDhR..t.....p...s.a.....hY...........t.t.........h.......h......p......l...........h......t.........tt..................sDshsRhhl+htEhhpShphlp.s...lp.......h.........t......s..................................................................................................................................................................................................................................hEss+G.....h.a..h.s.t..s.s.......h.a.Rh+hRsssa..p.h....h...h....t....luDh.hhhuo.s.hhsthD.....................................................................................	0	581	1119	1471
+1612	PF01512	Complex1_51K		Respiratory-chain NADH dehydrogenase 51 Kd subunit	Bateman A	anon	Pfam-B_780 (release 4.0)	Family	\N	20.50	20.50	20.80	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.86	0.71	-4.48	123	5590	2012-10-02 20:27:15	2003-04-07 12:59:11	12	89	3181	15	1614	4537	2950	161.60	39	31.64	CHANGED	lccuGlsGhGGA..GFPTtlKhssssc...........chlllNusECEPhlpsDctLhpcpscp..llcGhtlhtphl.uupcshIulcsphscAlpslppA......lp....ptpt.................lclthhsstYPsGsEptLlpslpG+..........tlPps....t..hP...hchGl..........lVpNVpThhslhp	....................................l+puGL+GRGG....A....GFPTGlKWphhsc.p..............................cYllsNADEsEPGshpD+tlM..cp.p..P..ap..................llEGhhIuua.Al.t.Ap.puaI..al+.uEa...p..Ahp.tLppA............ltcu..pp.shlt..........................................hthplpl+hG.s.G.tYlCGEEoALlpSLEG+.........tuhP+s..........+..PP.....ushGlh...............tPTllsNVETlssl..........................................................	0	615	1120	1387
+1613	PF00668	Condensation	DUF4;	Condensation domain	Bateman A	anon	Pfam-B_130 (release 2.1)	Family	This domain is found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (Pfam:PF00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.70	0.70	-5.57	42	20609	2012-10-02 12:01:53	2003-04-07 12:59:11	15	1841	2351	9	7271	22090	414	273.20	20	26.78	CHANGED	hpshhPloshQcthhahpphpssss.....uashsshlchps..sl-hpplcpAhppllp+H-uLRhhahpppt......hQhlhpptphplhhhphhs.........pph.chhhpc..hppsacLppu.PLh+stlhphtcs.pthlhhs...hHHllhDGhShsIlhc-ltphYpshp.......Lsshs............spapsau.hhpphtppt.hpcptsYWtphhpph.s......h.lstchspsstpshpst....plphslstt...htptLpphspppssolhslLlusaslhLpcasupscl.llGs.hsGRsp.....sslpphlGhFlshlPlclchp	.......................................................................................................h....hslo.h.Qp.t.h.h....h....h...t...p...h..t...........tss.....................ta.s.....h........h...h..h.....c......l.....p.................u......t..........l...........c......h.s........t....Lp....p....A..h....p....t.l.l..p..+..H..p..h..L..R..s...t.ah...tpss.....................t..h..Q....h................l....h......t.........t....h.......................h.....t.......h............h..h..s..h..t.t....................................tt.h...p.h..h.t...p.p.......ht..p...s...h..........c..l......t...........p.......s..........s..........l.......h....+....h......t...l......h............p............h...............s..............s................t.......p.............t..............h............lhls..................hHHl........lhD....G...h.S.h....t.l.lh..p.-....l....t....t..h...Y...psht....................hs.s...s......................................h.p.a...t..s...a....s......t...h..............p.....t............h............h..........p........s....................................h.......t.....p......p......h.........s.....a.....W...p....p.t.....L....t....s....h.s.s.....................................l...s.....h....s....h....s.......t....s...s....h....t...s..h...t...st...................ph..p.h.p....l.stp......httt.l..p..p...h....s....p.......p.....t.......t........s.....o.....h......t..l..l...h.u.u.h.....u......h......h.........L...............t..........c............h.............s.........s............p.............p..........-............l.....s........lG............hs.h......s....u.Rtt.......................s...s...h..p.p...h...lGh..Fhss.lsl+hp..t........................................................................................................................................................................	2	1552	3788	5729
+1614	PF00029	Connexin	connexin; 	Connexin	Sonnhammer ELL	anon	Prosite	Family	\N	20.60	20.60	20.60	20.70	19.20	19.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.33	0.72	-3.98	65	1256	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	120	6	656	1028	0	102.60	49	33.51	CHANGED	sWuhLtpLL-.pVppHSTslGKlWLoVLFIFRIllluluuEsVWuDEQScFsCNTpQPGCcNVCYDphFPISHlRaWlLQlIhVSTPo..........Llals....Hshaphc..+cc+tcp+	........................sWshLtplLp.t.Vpp...HSTslG....+.lW..LoVlFIFR..llllssAuEsVWu.....DE.QucFs.C.N.TpQPG.....Cp.NVC.YDphFPIS.HlRaWsLQlIhVSoPo..........Llahs..Hshaphpppc+....t...............................	0	61	128	329
+1615	PF03508	Connexin43		Gap junction alpha-1 protein (Cx43)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	37.00	37.00	23.60	22.80	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.38	0.72	-6.56	0.72	-4.69	3	90	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	65	1	24	85	0	20.00	92	5.88	CHANGED	RsTuSCRNYNKQASEQNWAN	..RNNSSCRNYNKQASEQNWAN	0	1	3	8
+1616	PF03509	Connexin50		Gap junction alpha-8 protein (Cx50)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	48.60	46.60	17.30	16.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.30	0.72	-3.67	4	47	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	33	0	25	40	0	66.60	70	15.69	CHANGED	IQKAKGY+LLEEEK..slSHaFPLTEVG.hEsu.Lsu.sFptFEEK...uhuPhcDhS+sYDETLPSYAQs	......IQKAKGYQLLEEEK..IVSHYFPLTEVGhVETSPLsA.PFspFEEKl...uTGPLu...DlSRuYpETLPSYAQV.	0	1	4	10
+1617	PF03601	Cons_hypoth698		Conserved hypothetical protein 698	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	24.50	24.50	24.60	25.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.00	0.70	-5.78	13	3130	2012-10-02 17:06:44	2003-04-07 12:59:11	9	5	2815	0	627	2177	1234	301.90	31	87.76	CHANGED	sGLLLshllullAhh.......Luph....hhstluAhslAIllGhlluN..ahphppphpuGltFupphLLRhGIlLhGhpLolspluslGhpullhsslslhuohllshalG.+hltLD+phuhLluuGoSICGAuAlhAspPVl+Acscc...VuhAIuslslFGTluhhlYPslhshhuhs......sctFGlahGuolH-VApVsAAGtthuspsss......sAllsKhhRlhhLuPhllhLuh..hhs+ppptutspst...+hs.....lPaFlluFlllullsohhhls........ssllshlsslsoahllhAMAAlGLssslstlt+sGhKPLlLu	.....................................................Glhl.shlluhhuhh....................lup.........h...hsh..luuhs..lAIllGhlls....s.....hh..t.........h..........p...................p..h....p.s..G....l.p....Fu....s....cpLL+huIlLhGhpL........shsp.......l......hs..lGh......t......u..l......l......h.......s.ll...s.....lh.....soh.....l......l.....sh.a......lu.+....hh....tl..D..c.c..h.uhLlu..sGouICGuu..AlhAsuPll...+...A...c...s...cc...........suhA.lus...lslaGoluhhlaPhl......h.s..h..h.shs........spsaGlasGsol.H-....lup.VlAAutsh...u...s..put.s...................hA.s....lsKl.h.RVh..h.....L...sP..lsl.ll.uh..........hh.p.....p...p..pp....t..s.psptt..................+hs.........................lPaFllh.Fl...ls..ul.l.so..hh.....h...ls............................ps....lh.s..h...l.....t.....p........l...s.phhlshAMuAlGLssplpsl.t.c..s..G.sKsllh................................................	0	209	414	530
+1618	PF03602	Cons_hypoth95		Conserved hypothetical protein 95	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.12	0.71	-4.89	27	4548	2012-10-10 17:06:42	2003-04-07 12:59:11	10	7	4379	14	1006	14823	4683	175.00	31	90.57	CHANGED	hRIluGph+G.......RpLts.su.pshRPTsD+VREulFNhltsh......lststhLDLFAGSGuLGlEAlSRGAppslhlEpstcuht.hlccNlptLth........thlhpssthth.phstps..FDlVFlDPPYtps....ppslphlsppshLp.....suhlhhEptpc.ttl.p.ssshphh+c+thGpsplphat	.............................................................hRIIuG.p.a+GRp.L....s......s....p..u....t..s...h...RP..T.o.D+..V.+.E.slF.N...h.Lssh................hp.s.u.p.s.L..D..L..FA...G.S..G....u..L..G...l......E...A...l.....S.....R.....G...A....s.......p.....s...........s.....h......l..Epst..pu..hp.....hlp....c..N......l....p....t....l.c.hps.......................hpll.p....t...s......s.....t............p.........s.........l............h......t......h......................................t.......s.................t.....t........F...D......ll...F.l..D...P.....P........Y...pp.......s........h.......h..............p.p........s.......l.p........h........l...t....p........p........s........h.L.s.......................ps..u..l..l.h..s..E.p..s...p..p..........t...h...s.......p............s....s....s....h....p....h.h.+.c.+thGpsthphh...................................................................................	0	343	672	859
+1619	PF04234	CopC		CopC domain	Kerrison ND, Finn RD, Bateman A	anon	COG2372	Domain	CopC is a bacterial blue copper protein that binds 1 atom of copper per  protein molecule.  Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm [1].	22.60	22.60	22.60	22.90	22.50	22.50	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.20	0.72	-3.36	162	1651	2012-10-03 16:25:20	2003-04-07 12:59:11	7	10	1283	12	405	1175	336	96.80	35	42.58	CHANGED	HupLhuosPAssuslssuPsplpLsFsEslp.......thuslpls.sssG.pshsssp.......spsss........pshslslss..Lss....GsYpVpW+slS.sDGHshpGsasF.sVp	..................HApLppssPAss.up..l..s..sA.PptlsLsF.....oEslp.s....................sFou..spls......ssps....c..s..lpsts..........................s.phst.....tstpplhlsLsps....Lts................Gs.YsVsW+lVS.s.DGH.spGpaoFoV....................................	0	101	242	333
+1620	PF00127	Copper-bind	copper-bind; 	Copper binding proteins, plastocyanin/azurin family	Sonnhammer ELL	anon	Prosite	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.54	0.72	-3.77	31	1467	2012-10-02 17:41:00	2003-04-07 12:59:11	15	49	912	431	532	1917	1988	103.80	25	50.66	CHANGED	spstlsscsus.hsFsssslslssG-plhalN.........sshsHNlVhsc.........DtlsuGs-sstlphsc.....cshl.usGEshSVThs...tsGs..YsaaCo.P.HtuhhMhGpVsVp	........................................................................................h.....thttss..htFp.P...s....t...lplps.G..s..s..l..p..a..h..s..................ss.hs..H...Nhshsp......................................sth..s...t.s.h.pt....hh.p..t.....................................t.h.......t......s...G..c..s....h..s..l..T..Fs.....psGs...Ypa.....h.....Cs..P....Hh...s.h....s.MhGplhV...................................	0	126	321	455
+1621	PF00649	Copper-fist		Copper fist DNA binding domain	Bateman A	anon	Prosite	Domain	\N	25.00	25.00	39.10	37.80	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.38	0.72	-4.76	23	240	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	128	1	176	247	0	39.50	57	8.31	CHANGED	M.llIsGpKaACtsCIRGHR...uSoCpHs.-R.Lh....cl+pKGRPs	................M.lIsGtKaAC...EsCIRGHR...sSsCpHs.D...RsLh....pl++KGRPs......	0	46	97	155
+1622	PF01218	Coprogen_oxidas		Coproporphyrinogen III oxidase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.00	20.00	22.60	22.50	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.90	0.70	-5.86	93	2155	2009-09-11 07:50:01	2003-04-07 12:59:11	13	8	1940	24	700	1719	2513	276.40	51	93.10	CHANGED	pplcsalhsLQccIspuLE....th.D...G.....ts..pFttDsWpR...t..pG.....GGGto+VLpsGpVFEKuGVNFSpVhGsthPsuAost..Rs-l.....uGt................sFpAhGVSLVlHP+NPalPTsHhNlRaF..lu...ptp...spsssWWFGGGhDLTPaYs.....a-EDshHaHpss+sACssa.GsshYP+aKcWCD-YFaLKHRsEsRGlGGlFFDDLs...p....hs...F-psFuFhpulGcuFLsAYlPIVc+R+stsau-cERpFQlaRRGRYVEFNLVaDRGThFGLQoG.GRsESILMSLPPhscWcYs.apPpsGS.EAcLhc.alts+-Wl	.........................p.tscpalhpLQDpICptLptl..D.......G........................upFhcDsWpR...p.s.G.................G.GG.po.....RV.........lp.............s..............G..............s...............VFEpuGVNaSpV.aGp.hhPs.uAsst...R.sch...........uGt..................................sF.AhGlSLVlHP+NPalPTsHhNsRaF....hs.................p...t....................st.ss........sWWFGGGhDLTPa.Ys.....a-....E.....D...shHaHpst+s.......hC.p..........s.a.......u....t....s.............h....YP+..a...KcWCD-YFaL+HR.s...EtRGlGGlFFDDL....s...s.............................s.....a-.p.sF.uF.hpuVGcuahsAYlPIVc+R..+..s..h.....sasEcERpaQLhRRGRYVEFNLVaDRGTlFGLQ.....TG..GRsESILMShPP.hs..+Wc..Ys.............a...........p...P..pss........S.EutL.p.hh...s+-Wl...........................................	1	214	409	570
+1623	PF03232	COQ7		Ubiquinone biosynthesis protein COQ7	Bateman A	anon	Pfam-B_3545 (release 6.5)	Family	Members of this family contain two repeats of about 90 amino acids, that contains two conserved motifs. One of these DXEXXH may be part of an enzyme active site.	22.00	22.00	22.00	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.23	0.71	-4.79	47	840	2012-10-01 21:25:29	2003-04-07 12:59:11	8	7	777	0	370	769	1628	164.50	33	78.42	CHANGED	thl-chIRVDpAGEhGAspIYtGQhtVLu....csphushlpcMh-QEptHhppFscLltc++VRPTlLtPlWcluGFuLGuuTALlGccAAMACTsAVEssIscHYssQlcpLt......ps-tc......................LtspIpcFRD-ElEH+Dhulpp.sAcpAssY.lLopsI+hGCRsAIhluc+l	.........................................t..httlhRVsHsGElsAptl....YpGQh..h.........shp..........pspl+thhp.chhcpEtcHLshhpchlp.ch..ps..R.P.olLsPlWh.s.uuau..l...G.......ss.su.lhGccsuhuhssusEcplspHhsspLcpLs............tp-tc..........................psllcphRpDEhcHt.cpA.......lct.u.u..t..p..h................h.th....t.......................................................	0	111	206	296
+1624	PF04803	Cor1		Cor1/Xlr/Xmr conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6320 (release 7.5)	Family	Cor1 is a component of the chromosome core in the meiotic prophase chromosomes [1].  Xlr is a lymphoid cell specific protein [2]. Xlm is abundantly transcribed in testis in a tissue-specific and developmentally regulated manner.\	     The protein is located in the nuclei of spermatocytes, early in the prophase of the first meiotic division, and later becomes concentrated in the XY nuclear subregion where it is in particular associated with the axes of sex chromosomes [3].	22.10	22.10	22.40	23.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.66	0.71	-4.39	12	157	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	50	0	76	193	0	115.40	34	52.16	CHANGED	sKsLpsKRKRlEshoKsShKuSppKlEplW+TQpspRQKLsp-aSQQhhslhQQW-hDspKhcEQcEKLsNhF+QQQKlhQQuRlVQsQ+lKsl+pLaEQFlKshE-lEKs+-shhpusQpEL+KEMAhL	.......................sL.tK+++hph.spsohps.pp+l...cphh+spp.ppRQKlspcaSpphhslhppa-hDhQKhcE...p...c....EK....ls..s..happQQK..hhQQschlQpQ+Lcsh+plh-palKshpslEpsppphh.shpsEhcc.hs..............................	0	12	14	22
+1625	PF01544	CorA		CorA-like Mg2+ transporter protein	Bateman A	anon	Pfam-B_944 (release 4.0) & Pfam-B_3206 (release 7.5)	Family	The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli.  CorA is virtually ubiquitous in the Bacteria and Archaea.  There are also eukaryotic relatives of this protein. The family includes the MRS2 protein Swiss:Q01926 from yeast that is thought to be an RNA splicing protein [3].  However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.91	0.70	-5.38	79	8370	2009-01-15 18:05:59	2003-04-07 12:59:11	13	47	4035	34	2466	5606	407	264.00	18	74.31	CHANGED	tpshhWlclptsspp..phphLtpt.......hslst.h.hp........hhstppps+h-.......hpsshhlhlpshphspsspt...h.......lshhl.ssshllTlppps...hphh.......pplhppht........ttht.pssttllhtllptlscphhphlcplppclcplEcpl............pppspphhpclht..l+...+p.lspl....+chlhsppphl........phhp......pttthhsppp......lpclhsclpp....lhpthphhp-hlptlt-thtshlspp.......hNchh+hL...Tlloslh.lPhTl..lsGhaGMNht......hP......thphta......hhhhhlhlhhlhshlhhhhh......++	...............................................................................................................................................................t....hWlpl.t.sptp...pht....ltpt.......ht.l...h..hpt...........hh.p....p.p.ps..+hp..................t.s.h......hh.l..h....h...t...h...h..p.t.ppp..................................l.thhl....t........p.....p........hllo...hp...pp.......hh...............................pthhpph...........................tthh.hss....t..h.lht.l.h.......p.ths......cth....hth.l.cp.lppp...h..p.pl-.ppl.............................ttptp...p..p........h........t..plhp.....lc.........cp....lhhh........................................ppslt.....s.......p.p.hl..................................phhp.................t..h....h...hs..p.p.p.....t..th...........hc.-.l.hp.chpp...................hhph.hch...h..t...ph...ls...t...h...h.......p.......sh...h...u...h...l....stp.............................N.p.......h.......h...c.......h...l..............olh.......oslh...lP....Th...ls..u...h..aGM.N..hp................hP................thp.h.ta..........hh.h.h.s........lh.hh.l.hhsh...hhhh.hh.++...........................................	0	668	1466	2076
+1626	PF03311	Cornichon		Cornichon protein	Mifsud W	anon	Pfam-B_3813 (release 6.5)	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.70	0.71	-4.00	31	647	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	286	0	397	527	2	110.50	35	84.83	CHANGED	Mu.phh.h.alhulllssshlFhtlaalIhhuDLEsDYlNPI-hCs+LN.hVlPEhhlHuhLslLFLlsGaWhsFL........LNlPllsYNshphhp+.....spl..lDsT.EIF+p..Lstcp+cshlKLuFYLlhFFhYLYp	...............................h.h.ahhullhsss...lhh.laal.....Ih..hs-LcsDYhN.Ph-.Cs......p..........LN.................hllPEhh..l..Huhhsl.ha..L...hstpWhhhh........LN.l.Pl.lhaphh+.hhpp.......tl..hDsTpIhpt.......Lshpp+-uhhKLuFaLl.FFhYLY.....................................	2	101	172	283
+1627	PF04694	Corona_3		Coronavirus ORF3 protein	Mifsud W	anon	Pfam-B_5763 (release 7.5)	Family	\N	23.60	23.60	25.00	54.80	23.20	23.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.21	0.72	-4.09	4	89	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	40	0	0	78	0	59.00	82	84.35	CHANGED	MDIVKSIshSVDAVLDELDsAYFAVTLKVEFpoG+hLVCIsFGDTh.tA..phhu.Lthc	MDhVKSIshSVDAVLDELDshhFAVTLKV.FpoGKLLVCIGFGDTh.EAcpKAYAKLtL.......	0	0	0	0
+1628	PF03262	Corona_6B_7B		Coronavirus 6B/7B protein	Mifsud W	anon	Pfam-B_4476 (release 6.5)	Family	\N	25.00	25.00	208.10	119.30	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.46	0.70	-5.08	5	357	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	39	0	0	270	0	194.70	87	100.00	CHANGED	M.IVllLVClhLuNuhGIKtssQEcDL...HEHPThTWELL-+FVGNTLYITTsQILSLPLGAcV+C-sVEGFsCoWPGFcssAHDHIDFYFDLSNPFYSFVDoFYIul...G-tspKIsLRlVGATPK-KRLNlGCHTSFu.VcLPFGTQIYHD+DMphhV-GRHLECTHRVYFVKYC.PaasHGYCFcDKLKVYDL+Rl+SpKsF-KlNQac+oEL	....................KATTVQsDL...HEHPVLTWELLQHFVGHTLYITTHQlLALPLGSRVECESVEGFNCTWPGFQNPAHDHIDFaFDLSNPFYSFVDNFYI.l...GEGNQRINLRLVGAVPKQKRLNVGCHTSFA.VDLPFGTQIYHDRDFQHPVNGRHLECTHRVYFVKYC.PYNLHGYCFNEKLKVYNLsQLRSKKVFDKINQHHKTEL..........	0	0	0	0
+1629	PF02398	Corona_7		Coronavirus protein 7	Mian N, Bateman A	anon	Pfam-B_1574 (release 5.4)	Family	This is a family of proteins from coronavirus which may function in  viral assembly. 	22.30	22.30	23.10	47.60	19.00	22.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.39	0.72	-3.53	2	105	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	47	0	0	81	0	77.30	75	100.47	CHANGED	MLVhhpAVhlTVLhLLLIGRlQLLERLLLsH.hNLpTVs.......................DFNILa+sLAETRLLhVlLRlIFLVLLGFsCYpLLshLh	..MLVFLHAVhlTVLILLLIGRlQLLERLLLsH.LNLpTVsNVLGVsDssL+VphhQLLKPDCLDFNILa+sLAETRLLhVVLRVIFLVLLGFsCYpLLssLh......	0	0	0	0
+1630	PF03187	Corona_I		Corona nucleocapsid I protein	Mifsud W	anon	Pfam-B_2926 (release 6.5)	Family	\N	25.00	25.00	75.50	75.20	24.60	16.30	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.43	0.70	-5.17	3	82	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	48	0	0	55	0	183.00	55	98.69	CHANGED	MESSRRPLGLTKPSADcIhKIEAEGISPSRLQLL.NPIPGVWFPITLGFLALPNSRRERSLSLQhDKECLLPMESQLLSKRDIGIDTTDVLLKHLMASRSNYCPDGIFTILEQuPMLcsSMATsLTESSGSQlsRhhspPLLTLLKGTQVAMRLFLLGLRPVRYCLRVoMLKAQEGLHLLVDLVRGH..NPVGQIIALEAlPTSASLPLL	....tS.pt.l...p.o..ph.h.tsEp.NPspLhLL.NHpEshh..hI.GSLtL.sFK+.coLNhQhsK.h.LhpES.LLKpRDIGhDTTsVLLKQLMus+SsCspDGIFTIhtQs+MPtpsMssshptSSGSLlT+Lh.lPh.hFppGhQlsMRLFhLGhR.sRasL+shhLKAQEGLhLlsDLl+uH..pPlsQ.hshEsh.s.ts.PLl........	0	0	0	0
+1631	PF01635	Corona_M		Coronavirus M matrix/glycoprotein	Bashton M, Bateman A	anon	Pfam-B_845 (release 4.1)	Family	This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The M protein or E1 glycoprotein is The coronavirus M protein is implicated in virus assembly [1]. The E1 viral membrane protein is required for formation of the viral  envelope and is transported via the Golgi complex [2].	19.10	19.10	19.30	19.30	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.48	0.70	-5.39	14	976	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	276	4	0	775	0	199.50	48	97.13	CHANGED	h.SN...solshp-llphl+sWNFshsl.ILlhlhllLQaGYss+S+hlYllKMhlLWLLWPLslAlolFsAl..aslN.hshhuhSIlhAslohlhWlhYFlsSlRLapRTcSaWSFNPEoNsllslsl.hGpphshPlhpsssulThsllsGpLhh-Ghclup.sssssLPphlTVApPsshhhYch.u+..s.shsssoGaAhYl+hKt.Gsaptssshpsshs-sppLhp	........................sh...tphh.....hhtpaNh.hsh.hh.hh..hhhlLQaGhsphShhlYhlKMllhWlhWPlslAlslhssh...Ytls.h.VhhuhSIhhAllsh.hhWlhYFVpSIpLa+RT+SWWSFNPETNAlLslsh.hGpphshPl-usPpslThTllsGsLYsEGhKlAsGhsl-cLPKaVhVApPoRphlYph.VGK..p.puussoGaAhY...V+uKt.G.sYs.spshpsshopttpLh....................	1	0	0	0
+1632	PF04753	Corona_NS2		Coronavirus non-structural protein NS2	Mifsud W	anon	Pfam-B_3747 (release 7.5)	Family	\N	25.00	25.00	26.60	179.60	24.00	17.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.68	0.72	-4.11	3	81	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	63	0	0	43	0	108.40	73	99.55	CHANGED	MEIWRPShKYLRhTR-FGVT-LEDhCFKFNYCQP+VGYCRVPL+AWCRNQGKFAApFTL+S+-KSa+ppFGVITSFTAYGNTVcEAVSKLVEpAuDFIsWRAppLN+YG	..MDIW+PEhKYLRYTNGFNVSELEDsCFKFNYpFPKVGYCRVPs+AWCRNQGpFCAThTLYGKSK+.YDKYFGlITGFTAFuNTVEEAVNKLVFLAVDFITWRpQpLNVYG.	0	0	0	0
+1633	PF05213	Corona_NS2A		Coronavirus NS2A protein	Moxon SJ, Bateman A	anon	Pfam-B_6568 (release 7.7)	Family	This family contains a number of corona virus non-structural proteins of unknown function. The family also includes a polymerase protein fragment from Berne virus and does not seem to be related to the Pfam:PF04753 Coronavirus NS2 family. This family is part of the 2H phosphoesterase superfamily [1].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.74	0.70	-5.06	4	104	2012-10-03 21:31:47	2003-04-07 12:59:11	7	4	66	0	0	95	1	202.80	52	38.20	CHANGED	AYADcPsHFlshPlsp.psFltsahcLQ.....EGhssKhQsAPHISLTMLclpsEDhcpVE....-IlD-Mshspu..lshsNPHMhG+phVhDVcGl-pLHD-lVslLRc+GhssDQoRhWhPHhTIuplpDsuh.sKh.......hpFshpppl..........tch-hVKLGAsKtsuhYEhIso...........sWsupR.LCapsss.p.Sc.htYhsLss...EhptG.l..Ncsss...hShcYpsppahh++V+DpSpa..hRTu	............................AaADKPNHFINFPLspFpGFhhpYhtLQ.Qll-..G..lDCK....lQpAPHlSls...hL.D..Ip..s-pY+sV-....hAIQEllDDhthh..EG..pIpF-NPHh.L.G.R......ClVL.......D.V.+G.VEELH-...DlVNhlRc+GCsADQSRpWIsHCTlAQhs-tslpIKt.........hQF.a.Kh.sh.....N..osAclElVKlGupKh.DGFYpo.hS...........hWhG.R.hpYpPPTsKhu.IhGYCCl-hlRt-LE.GDLP.sD--AWhcLSYHYppNoaFFRaVacpS.Y..FRp..............................................	0	0	0	0
+1634	PF03053	Corona_NS3b		ORF3b coronavirus protein	Mifsud W	anon	Pfam-B_2130 (release 6.4)	Family	Members of this family are non-structural proteins, approximately 250 amino acid residues long. They are found in transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) isolates. These proteins are found on the same mRNA as another product, designated ORF3a. While ORF3a/b has been implicated in TGEV and PRCV pathogenesis, its precise role remains unclear (see [2,3]).	25.00	25.00	25.60	25.30	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.42	0.70	-4.81	4	228	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	53	0	0	204	0	211.70	53	99.20	CHANGED	MhLGLFphTls.......osVpposppsplSt-sshtlppsVVshRpssplsuFhlsSlFVhFFALFKAoSa+pshhllhh+lLslhlYsPlLhasGAYlDAhllsssLhuRhhalsaasWhYKsacFIlaNoTTLhFlpG+Asaacs+u....aVhL.GGspYlhlGsphVsFVSs.sLYlAIRGpt-uDLpLlRsVELLsGchlYlFSpc.lVGlsNuuFpp..L..........DchhsIS	...MIGGLFLsTLu.......hI.V.s.s.p.sh.l.s.Nhsp.s..slVQQ+pVV.Sup..hpShahEFSIAlLFVhFLALYRSTNFKsCVulLMFKIlSMTLlGPMLIsaGYYIDGIVTT.TVLuLRFlYL.uYFWYlNSRFEFILYNTTTLMFVHsRAAPFhRSSHuSIYVTLYGGINYMaVNDLTLHFV.ssh.l......hlAIRGhscADLpllRsVELLN.....GchIYlFSQEsVVGlhNAAFsph.l..........sc........................	0	0	0	0
+1635	PF03905	Corona_NS4	Coronavirus_NS4; 	Coronavirus non-structural protein NS4	Finn RD	anon	DOMO:DM04795;	Family	\N	25.00	25.00	42.70	42.70	18.80	16.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.22	0.72	-4.16	3	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	45	0	0	37	0	47.40	70	65.50	CHANGED	MPMATTIDsTDYTNIMPoTVSTTVYLGuSIGIDTSTTGFssFSa.............Y	MPMATTI-GsDYTNIMPhTVhTTVYLGsSIGIDTSTTG.pshsh.......................	0	0	0	0
+1636	PF00937	Corona_nucleoca		Coronavirus nucleocapsid protein	Bateman A	anon	Pfam-B_267 (release 3.0)	Family	\N	24.60	24.60	29.90	25.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.18	0.70	-5.50	21	1034	2009-09-11 06:29:42	2003-04-07 12:59:11	13	4	296	36	0	939	0	294.10	37	87.79	CHANGED	Mu........................plsatsp...stppsppttt......hPh.......................SaFssLptpscpthh.hhsGsGVPhutG.stspphGYWpRQpR..a+.scGppppLss+WaFYYhGTGPaA-hcatc.......cp-GVhWVApcGAcssssu.lGoRsssp...pslss+Fssu..lPpshhlps......pspSRssSRus......SR...upS..RusSts..........uRssS...psRpsss...............lhsslhttLtslshsppp.........................tsppssploppsst-stp....K.caKRossKu..psVspsFGtRussp...NFGsschlctGscsspaPtlAELlPosuAhhFuSclssccps..Dsl.........plsashshpls+csPshppah....pplsAY...........scPpcp.cK.pppp	...............................................................thsh.......................SaFpslp.pphst...hhtspuVP.s.s.ptspQhGYWpRpsR..a+.scGtpK.lsstWYFYYhGTGPtAchpats........p.-GlhWVAtcGApspsps...GsRsssp...-thsh+Fssu..hPps.hh.s..........pGcSttsot..us......S..t....upS....Rs.sS...............RpsSpsRpssu........................................t.sl.hsthtplh.spp.p..............................ps.pphs.p..tpss.-h.p......+.hhKRT.s.t...pVspsFG.Rs.sp......NFGDsch.ppGhpstphsthhphsPostAhhFGSpls.c.ts.sth...........plpaphshhlscscsphpphl....pplsuh................tcPpp.t.t....t...............................................	0	0	0	0
+1637	PF01600	Corona_S1		Coronavirus S1 glycoprotein	Bateman A	anon	Bateman A	Family	The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 and S2 Pfam:PF01601 [1].	25.30	25.30	25.40	26.50	23.40	25.20	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.94	0.70	-6.20	8	2634	2009-09-11 07:53:46	2003-04-07 12:59:11	11	4	115	4	0	2424	0	374.30	50	73.17	CHANGED	hhG.us.VahhpSuh+.PcGaphpshhhhssssos.susssSsQ....sClhul.taupsssssShshTAss..sGhShsss....cFshs.......csNhsctslFlTasapo.hshuCs.ouh......l.puah+IshhKsts...salFYNlTls.......luphPphhp..slsphsSVYlNGahhFTostscsVshusspacoGG.....hThtlhphVcALs.hsNsohpcVIhCD.SPhuhLtCQ.sTuNhsDGFYPhoso....phhlVhppsSVsTh.shpsaTFsNlosu.........PssGGlpohslYtopsspouhhNFNhohlouFsh+sSpFhhhsa......h.pspFpspshNsGhWhNSlslu..hs.hslQussc.ssFu...TsCauhShsGsusshuVausphsp.apshhhlYVoho-GShIpTuspsPlhshpsasNlTLDcCs-YNIYGRsGpGhITNsTsohlut.........Ih.TSsShDlhshpsshusshYpVsPC-ss.pQhVVssGclVGllTShNpTu............p.htN.aYlplhNhT+hhpR	...............................................ts.VahhQSuhR.spGWHlpGGAYAVVNsos.ssNAG....o....up.............p...CT....s..Gs........I.......p.....s..h.......s........s.......Au....Sl...A..MTAP...........pGMuWSps..................QFCoA.........HC..NF.o...-...h....o...VFVTHCaps...suCPlTGh.......l.psaIR.ISAM.+..s..........upL....F..Y..NLTVo..............VuKYPpFKShQCVNNhTSVYLNGDL..V.FTSN.p.TpDVsuAGV.a.aKu..G..G....PlsY.plM+phcsLsaFsNGospcVlhCD..oPhshLt.Cp......shshsDGFYshss.......hhhs.h..pShsTh...hpsaoF.N.osu.........ss...u...s.h.p..s.h...hhts..t.hps...sh.h.sFs.s.h..s..Fsh...ptsp.ahh..................s.F...h....ps..s......Ghh...sslsst.....s..h.shpt.hsp..sFp......phC....h.......uhs......ss......hphsl..hth...t..........phh.lahphptGp.h.ots........h...h..h.hs.CstYslYsh.G.GhIh..s....p...sh.........lh.so.uhphhhhps.....hapl.PCt...tQhsh.ttthhs........................................................................	0	0	0	0
+1638	PF01601	Corona_S2		Coronavirus S2 glycoprotein	Bateman A	anon	Bateman A	Family	The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 Pfam:PF01600 and S2 [1].	30.00	30.00	30.20	30.10	29.90	29.00	hmmbuild  -o /dev/null HMM SEED	610	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.17	0.70	-6.42	22	1416	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	312	44	0	1305	0	413.10	39	54.14	CHANGED	sCs.Ph.....lsYushulppsGulht.lshp.......s.stlsslhs.....tslpIPoNFTlolpsEYlQhpsp.lolDCupYVCssss+CppLLpQYuohCpsIpsuLptsupl-shplhshhoss..puhpls....shpsFsus..................aNhosl...Lsss..........up.t.RSsIEDLLFsKVhouGlGtVDttYccCos...G..tsltDLlCAQhYNGIhVLPsllssphhuhYTuSLlGuhshG....Gl.TuAAuIPFuhslQuRLNalulppsVLpcNQKllAsuFNpAlusIpp..............GhsosupALsKlQ-VVNppupALspLssQLssNFtAISSSIp-IYsRLDtlpA-AQVDRLITGRLsALNuaVoQpLschsclcsSRpLAtpKlNECVKSQSpRhGFCG.sGsHlhSlsQsAPpGlhFlHhshlPopatsVpAssGlClss.....hhhhhsPthulFh......psso..........ahlTsRshapPchhotu-hVplpoCsVsasslsps.lsshl.P-..hhDhscpLscahpsh..spshPshs..hshaNhTh..LNLosEI..............pcLpplIcsLNsohlDLc.LsphEpYlKWPWYVWLsIshullhhlhlLlahhhsTGCCG.hhuChu.....spCtppCp...thpp...h..hcphHsp	.......................................................................................................h.lP.thshs...Ehh.h....h.lss..alss....C...h.pYh.hC.pl.t.l...s...s.....hh.........................................................................................................................................thYTsuhhuuhshu....uh.ouAsul.PFuhplQhRlNhlulppslL.cNQchlAsuFNpAluphp...............uhpohs.ALtplQsVVNpputhLsphhtpLppNFtAISSslt-IhppL-tlpApsQlDRLIsGRLsuLsshsotp..phhclptptpLAhpKlsECV+SQS.RhsFCG.pG.HlhohspsAP.GhhhhHhsh.P.t..ph.s.suhChts................hh...t.shh.........t......................ahho.p.ha.Pp..p.tshl.htsCtssahphs.s.h...h..p....shpcplpchhpph..p..hs-...hs......hN.Th..LslptEI..............pclpthhpslNpohlsLp.lshhc.........................hhhh.Tsps..........ssh........ht.......................................	0	0	0	0
+1639	PF00115	COX1		Cytochrome C and Quinol oxidase polypeptide I	Finn RD	anon	Pfam-B_23 (release 1.0) and Prosite	Family	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.90	0.70	-5.86	94	254351	2009-09-13 13:30:05	2003-04-07 12:59:11	15	23	108179	109	2006	206187	5121	227.90	58	95.26	CHANGED	pcp.luhhYllhuhhhhllGslhullhRhpL..shP...................sh...lssp....saNplhohHushMlahhshshhhG.hu.allPhhluscplshP+Ls.shuaWlhshusllshhuh......hhths...............stsWh.Ys.Phs....................s..hhhhulhlstluullsulNhlsT..lhphRs.uhsh..h.slh.sWuhhssullhlhuh.Pslshs.hhh.h...h...hh..stsussllapalFWaauHPtVYllllP.uhGllu.llsphs.t+.lauaphhhhuhh.uluhlu.hhlauHHhas.sGhshhhpshhsstohhlu..........lPsult...........lasalsT......hhtu....p....hphs.sshhasluhlhhF.hhGGloGlhhuhsslshhhHsTaalVAHaHhslhGuhshshhuulaa....hhPphtGp.....hhsppluphpFalhhlGhslhFhshph.hGlh.GhsRRh....hsa......sst.......htsa.....hlpolG..uhlh	........................................................................................................h.lG.suh.ShlIRhEL....upP...........................suh....lssDQ........lY.Nsl.VT.A.HAFl.MIF.FM.VM....P.l..MIGGFGNWLl...PL..M.lG...A..P............DM....A....F..P...R....M.N....NM.SF.W..LLP.PS.lhL.Lls.So.....h.V.....EsGs.......................................GTGW.T....V.YP...PLu.usluHs............GuSVDLuI.FSLH..LA.GlS.SI.L.G.AI..NFI.T.T.........l..I...........N......M........+..............s..........s...h..o....h...c........p......h.......PL.......F....V..........W.........u........V.........h.IT.Al.L.L.....L.L.SL..P..V..LA.G....A.I..TM.LL.T.D..RN......l.NToFFD...............PuGGGDPl.La.phh...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	538	1218	1661
+1640	PF05051	COX17		Cytochrome C oxidase copper chaperone (COX17)	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_5838 (release 7.7)	Family	Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast [1]. The structure of Cox17 [2] shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.	21.80	21.80	21.90	22.20	21.60	20.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-8.95	0.72	-3.94	43	302	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	243	7	199	288	2	48.60	48	61.89	CHANGED	ppKP...KsCCsC.-pKcsRD-Cll...pGp-p.....CpchIEtaKpCM+uhGFpl	..........p.pKP...hKPCCsCP-TKcsRDp.Cll.....pGp-s........CtphIEsHKpCM+uhGFpl.............	0	65	105	163
+1641	PF00431	CUB		CUB domain	Bateman A, Finn RD	anon	Pfam-B_136 (release 1.0)	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.53	0.72	-3.98	29	12961	2012-10-02 11:50:15	2003-04-07 12:59:11	15	883	190	46	7617	11572	76	107.50	26	32.62	CHANGED	CGsp....lppssGslpS.PsaPp.sY.ssppClWpIpss.uhp..lpLpFps.F-lEtpt.......ChYDalElhDG.tss.t.hlG+aCG.....pthPssltSsusphhlpFho.DsshsppGFphsa	......................................................................Cut......hp..t.....s....G...h...lp...S...P....s.......a....P.......p........s...........Y......s........s......s.....h...........p.....C..h.......Wt..........I......p....s......s..............s.....p.....p...............l...p...L......p.....F..p......p...F...p.l...E.......................................C....t.......h....D....a......l.......p........l.....h.....-...............G......s............s...............t...............p........s.......................h...........l.............u.......p............a.............C....G.......................s.p..h..P...t....s.....l......h...S......s....u.....s.......p....l..hlpF...p......o......D.....t....s.....h.....s.....t...p..GFphpa..............................................................................................	1	2339	2836	5004
+1642	PF00116	COX2		Cytochrome C oxidase subunit II, periplasmic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.47	0.71	-4.28	32	31269	2012-10-02 17:41:00	2003-04-07 12:59:11	15	29	18166	144	1320	28095	2586	106.00	48	47.64	CHANGED	lTlKulGHQWYWSYEYsDa.s.....lpFDSYMlPpppLp.sphR....LL-VDNRhllPhssplRhllTu....sDVlHSWslPShGlKhDAsPGRLNQsohhh...sRsGlaaGQCSEICGsNHSaMPIslEul	................................................................lTlKslG.HQWYWS...YE..Y...o..D..a....s..........................l..p.F..D.S...Y.......M....l.........s..........p......p........-.........h..............................s.p........F.......R.............................LL..-.....VD...N.....R.l.....l..lP..hsspIRlllTu......s.D....V....l...HSWs...l....P.....u........L..G....l....K........h........D..A..s..P.....G.....R........L.N...Q...s...s...ahh....................sR...P......G......l...a.a......G.QCS.ElCG......ss.Hu.h.Ms.hhh........................................	0	349	789	1076
+1643	PF02790	COX2_TM		Cytochrome C oxidase subunit II, transmembrane domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.	21.00	18.00	21.10	19.70	20.80	17.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.03	32	25391	2009-01-15 18:05:59	2003-04-07 12:59:11	10	24	16352	78	555	22832	1763	78.90	47	36.87	CHANGED	MsT.hshs...hQDuuSPhMEplhhFHDashhlLhhIhhhVsalhhshlhs......phsp+ahlcGQh.IEhIWTllPAllLlhIAlPSL+L	............................Msp..phs....h..Qs...usSPlMEp.Lla.F.H.DHs..l..h..I....l...lh...I.o..h.l...V....s..Y.lh..h..h.l.h.hN................................K.hs.s.+...h...ll.-u.Qh...IElI.....WTIlPAllLlhIAlPSLRL................................................	0	162	342	451
+1644	PF00510	COX3		Cytochrome c oxidase subunit III	Finn RD	anon	Pfam-B_78 (release 1.0)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.69	0.70	-4.94	21	13171	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	8530	60	1326	11262	3530	206.40	41	93.84	CHANGED	HPFHlVssSPWPlssShuhhshsluhlhahHsap..hhllhlullsllhsMhhWaRDllREuTapGpHThhVpcGL+hGhlLFIlSElhFFhuhFWAFFHSuLuPolELGusWPPhGI..pslNPh-lPLLNThILLoSGsTlTaAHHullpG.pRppul.uLhlTllLulhFThhQhhEYhpAsFTIuDuVYGSsFahuTGFHGlHVllGTlFLhVshhRhhpaHhTspHHhGFEsAhaYWHFVDVVWLFLYlolYWWGu	.........................................................................................................................................................................................................................................................................................................t.t..............G....Hs..............l.............u..h.+..h..........G...hh.LF.Ih.S.E.l.hF.....Fhu.a.F....WA..........a......a...................p.........u.................u....L........u..........P..............s.....................................p........l.................G.................s............h....................W..P...........P..............t.......G.......l.................p..s.......h...s....P....h...p...l..........P......L....L....N..Thl....LLuS......G...l.o....lT...........a.........A...HH............u...........l...........h.......p.............s.............p.............c................p......p........s..............h.t.u..........L.........h.l.T..l..l...L.GhhFsh..l...Q...s...h...E.........Y........h..........c..............s...........s.........F................o.........l.......u.......D..............u...........l...........Y.........G......S.......sF...F....h....s..TG...FH.GlHV...ll..G.oh.aL...h.......l..sh....h...R..........h...........h.........h......c.........a........o...........s..........p...........p..........+..........h..........u..........h............c...s.....su.........h.......YWHFVDl.VWl.h.lah.lYh...................................................	1	358	800	1075
+1645	PF02284	COX5A		Cytochrome c oxidase subunit Va	Mian N, Bateman A	anon	Pfam-B_7466 (release 5.2)	Domain	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit Va.	21.30	21.30	22.00	25.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.43	0.72	-4.10	3	318	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	272	51	176	300	0	103.20	52	69.73	CHANGED	uHGoEETsEEFDARYEKYFs+EuIDuWElRKGMNsLlGYDLVPuPKIIEAALRAuRRVNDlAoAIRlLEulKDKsGscKt.lYPYlL-EL+PTLQELGIPThEELGhDK	......................H..pp.E.T.EEFsA.R......a.phFs.sshDsaElp+uhNs.hhuYDLVPpPcllpAAL...RAs...RRlNDaAoAVRlhEulKsKst.s+.c.....YshhlpEL+PshpELGIsh.EELh.-..............	0	51	86	139
+1646	PF01215	COX5B		Cytochrome c oxidase subunit Vb	Finn RD, Bateman A	anon	Prosite	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.69	0.71	-4.50	4	403	2012-10-03 19:45:42	2003-04-07 12:59:11	14	3	288	52	248	395	7	118.00	33	69.68	CHANGED	S+ll+t.pslsp.suQsLt.s+tPs..oLltshuptGtVPTDh-QtTGLcR..hLuthpGpDsFshcsLcuo.pGThcDPllVpSlsshRhVGCpGususSHsllWhpltcscspRC.-CGoVYKLp.hus.scphtH	................................................................................................u....tls.....s-..-.p....ATGL.E...RhEl..lu.p.h..p.G.h.D.s......a.c....h.c.s..cus..hG...T.h-s...PhlV.s.Sh..hscRlVGCss....t....t.s.s.o..slhWhhl.c.c.s.c.s.p.RCspCGp.haKL...............................	0	84	137	203
+1647	PF02046	COX6A		Cytochrome c oxidase subunit VIa	Mian N, Bateman A	anon	IPR001349	Family	\N	25.00	25.00	28.10	27.90	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.92	0.71	-4.17	31	404	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	264	51	247	396	1	102.90	34	78.21	CHANGED	Mht.............t..t..........sh+RhhSo......................sstt.......tpta.pphtth.tHutu...soclW++loh.....hlAlPu.lslsulNsa.l..cscHt-HhtH.....-p-phspYsa.NIRoKsF.WGDGsKTLFWNscVNths	........................................thhhts.................................................................t...shtt..c.sts...su.....ch..W+p.loh.....h....lul.Pu.lslshlNsa.l.pcHtcH.....................tp.EhstYsahp..IRoK.sFPWG.DG.s..+.o........LF........aNsclN.h.s..............	0	67	115	186
+1648	PF02297	COX6B		Cytochrome oxidase c subunit VIb	Mian N, Bateman A	anon	Pfam-B_9188 (release 5.2)	Domain	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.	24.50	24.50	24.80	25.40	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-9.88	0.72	-3.96	58	675	2012-10-02 15:44:21	2003-04-07 12:59:11	12	9	292	51	456	646	0	66.70	32	59.76	CHANGED	schPs.........pspp+pCapshscaacClcp...pu........................spp................Cphhppsacs.CssuWlchac-p.....pcpshhs	....................RFPs..psQp+pCap.......sas-aa+Clct...psp......................................shss...............Cc.tatcsacohCPts......W....l..ccac-p......tt....t.................	0	125	227	364
+1649	PF02238	COX7a		Cytochrome c oxidase subunit VIIa	Bateman A, Mian N, Finn RD	anon	Pfam-B_3023 (release 5.2)	Family	Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the heart and liver isoforms of cytochrome c oxidase  subunit VIIa.	22.20	22.20	22.50	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.73	0.72	-4.24	8	306	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	111	51	138	301	0	53.40	42	59.85	CHANGED	+NKVhEKQKLFQpssch.sYLKGGh.DslLaRlTMsLslGGTuYslhuLGhAuhP+s	......pN+Vs-tQKhFQcsss..lPlaLKGGhsDs.lL..Y..RsT.Ms....L.....s...l...u........Gohhslh.thhhhs.s+t..........................	0	21	42	77
+1650	PF02285	COX8		Cytochrome oxidase c subunit VIII	Mian N, Bateman A	anon	Pfam-B_6423 (release 5.2)	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIII.	20.50	20.50	20.60	20.60	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.98	0.72	-4.43	11	112	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	71	51	45	114	0	42.40	43	59.90	CHANGED	VpSKPs+p.hushEpAlGloshFVoFLlPAGWlLSHLEsYKKpu	.....lpSpPscp.plushEpAl.GLoshFlshLlPuGWlLuHL-sYK+.....	0	5	7	16
+1651	PF02672	CP12		CP12 domain	Bateman A	anon	Bateman A	Family	The function of this domain is unknown, it does contain three conserved cysteines and a histidine, that suggests this may be a zinc binding domain (Bateman A pers. observation). This domain is found associated with CBS domains in some proteins Pfam:PF00571.	21.20	21.20	21.20	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.40	0.72	-3.51	39	291	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	151	16	114	305	584	62.40	34	39.64	CHANGED	ls-pIpcshpcAcpsCups..sSucCssAWDtVEELpAttuHpcpcpp....ppssLEpYC--NP-AsECR.lYDD	...................................tpplppthppActhsstt..ssspsttAW-t.l-ELpsttsHt.tpt......stssLE.....paCcsNP-ssEC+.lY-p...................	0	24	78	103
+1652	PF01383	CpcD		CpcD/allophycocyanin linker domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_887 (release 3.0)	Domain	\N	21.10	21.10	21.30	23.20	19.30	20.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.36	0.72	-3.79	86	448	2009-01-15 18:05:59	2003-04-07 12:59:11	16	9	103	2	124	392	105	55.10	34	24.05	CHANGED	u..RhFplcVsu.........tt...h.R+Sspshl.VPaschspphQcIp+hGG+IlSIsss	.........RhF+lcVsu.........tppp.pl.R+ospsal.VPYsphspphQRIpRhGG+IlSIpsh....	0	14	77	114
+1653	PF00166	Cpn10	cpn10; 	Chaperonin 10 Kd subunit	Sonnhammer ELL, Finn RD	anon	Prosite	Domain	This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis [1]. 	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.12	0.72	-4.05	48	6057	2012-10-01 22:45:51	2003-04-07 12:59:11	16	6	4946	114	1577	3685	2838	90.70	44	92.00	CHANGED	plcPLtDRVllct..h.pt.-p...potuGIllP..-supc..Ks..ppGpVlAVGsGhh..ppGp.hhshslcs..GDpVlascau.............Gs.clch..-.sccalllcppDIlAll	....................l+PLtDRVll+t....h..Es.Ep...cTs.uGIl.lP.....soApE....Ks...ppGc.VlAVGs.G...............p.h...................c..........s............G..........p..h..........hs.h.s.VKs...GDpVlas.cau....................Go.-lch........-.sc-aL.....lhp.EsDILAll................................	0	540	1020	1322
+1654	PF05205	COMPASS-Shg1	Cps15; 	COMPASS (Complex proteins associated with Set1p) component shg1	Wood V, Coggill P	anon	Wood V	Family	The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes [3].	22.10	22.10	22.10	23.40	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.43	0.72	-3.75	22	260	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	195	0	177	248	0	106.20	31	17.20	CHANGED	cpLsctaKKcGtFDphR+clLsch.cpu...........-tcpplpp+ltpllcsclpc-s.plL.+s+G+susLIcGtls+s............................shhpt..........s-pslss..ll-pclpch..tslcphh+ptltc-	................llpphKpcGhFDphR.+-sLu-h.csp..............suhpsLpp+lcshVpscls.cpp......shN+..sphpshl.ctplhcS............................hl..ps............s-ch....lsp....llcs+lsch..hsplcphh+p.l...t.....................................................................................	1	43	76	128
+1655	PF00289	CPSase_L_chain	CPSase; 	Carbamoyl-phosphate synthase L chain, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.	25.50	24.50	25.50	24.50	25.40	24.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.17	0.72	-3.96	157	23989	2009-01-15 18:05:59	2003-04-07 12:59:11	17	163	7729	193	5850	19831	8081	108.40	33	18.02	CHANGED	hhc+lLlANRGEI...........AlRlhRss+ch.............Gl.coVslaoss..Dpsuh...asphADcshhls..s...s.........tuYLsh-pllpsA..cps........G.....spA.lHPGYGFLSEsscFActst..p.tGl..hFlGPsscsl	...................................................................hc+lLlhs.pG.I...............................ulpsh+uh+-h..................Gh.col.hV.ss.ss.............-..o..sus.............chph......AD.c.....s..Yh.s...............................lsh.-tlhplhchp.........................u...s.s...ha........sG....sh.Ls.s.hph..tp...h..........c..tGl....hhlGssscsI......................................	0	1856	3641	4921
+1656	PF02786	CPSase_L_D2	CPSase; 	Carbamoyl-phosphate synthase L chain, ATP binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. The ATP binding domain (this one) has an ATP-grasp fold.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.13	0.70	-5.05	16	23031	2012-10-10 13:17:03	2003-04-07 12:59:11	12	179	6767	194	5911	27500	13103	197.30	32	31.79	CHANGED	D+tthpsthschshPssPusss...coh--AlthAcclGYPVII+uAauhGGpGhtlspsc-Eltclhspuhspu......splLlEK.lcs.KcIEhpVlpDupsNsIplsshEs.s.h..+stcsl.hAPSpTLo-cphphl+psAlpls+clGhhGus.slpahlss..stcahhIEhNsRlphppslupcsTGhsLshhthKlAhGhsLspl	.............................................................................................................D+tthpp.h.h..pc..h..s..ls.......h........s.............ut....t...s........................p......s..........h.......-......-...........A............h.............t........h............A.......c.........c..........l.............G....Y...P...l..l......l.......+.......s.u.......h.......s........h........G.....Gp.........G.......h....p........l.........s.........p.......s....c.......c...........-.........L....p................p.h..h.................p.......p.................u.......h.................p.................t.................u...................................................................................s.......s.......t.................l...........h.......l..-.+.h.l....t....s........s....+......c....l......E...l........p......l.......l........s....D.......s.......p........s.........N.........s.........l........h.......l.......s.......p......h..........-......s............pt................+s..t........c.....s.............l......p.............................u.......P.......u.............................s.............L......o........s.................c................h.....................p.........t......l....t....p..s....u..........h....p....l.....s...........+t....l.....s.....h....h...G....s..s.....s...l...p..F.......h.......l.........s...............................s...........s..................c...........h...Y..hl..E........hN.s....R....l...p.......h....p...p....s...l...s...p..p...s.........T......G.........h.....s.....lschth+.lA.hG.sLs..h..................................................................................................................................	0	1878	3684	4980
+1657	PF00650	CRAL_TRIO		CRAL/TRIO domain	Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.70	0.71	-4.74	110	4026	2012-10-02 01:12:42	2003-04-07 12:59:11	15	76	365	19	2809	4545	94	152.30	20	37.53	CHANGED	th.hptththlhGh.DppGRPlhhhcht.thssp....sts..t......................phhchhlhhhEpsh..................hhtt........thsshsllhDhpshs.....htphs....hshh.+hllphhp.spYP-pLtplhllssPhhhsshapllp..sal.sspsppKlpht.pstp...........Lppals...cplsp.......phG.Gp	....................................................................................................t......h..h.h...th..D...p.p.Gcslh..hhphs..ph.ssp................phs...p.........................................ch..h+.h..h.hhhhE..thht.....................................................h............................thp...shshlh.Dh..p...uhs..............h.p.p.h...t.............hphh...p.......p....h....hph..h.......p....stYP...p...plt..p..h...hll...........N.......s....P...h......h.a...p.s.ha.p..l...........l+................sa.l..s.........t.ps...t..pK...lhh...h...ts..t.t..t..........tLhp..h..l.s.........p.LPp.......phGGp.............................................................	0	1013	1571	2350
+1658	PF03765	CRAL_TRIO_N		CRAL/TRIO, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This all-alpha domain is found to the N-terminus of Pfam:PF00650.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.54	0.72	-3.83	148	2100	2009-01-15 18:05:59	2003-04-07 12:59:11	10	27	310	19	1402	1996	17	56.30	25	13.53	CHANGED	pptlpp....lcphltp............................thhptph..............sD..thlLRFLRARcaclpcAhpMlpps	...............................................................................................................h.p...hcphltp...................................t.hhttph...................................................sD...thLLRFLRARcFclpc.Ahphltp..............	0	364	715	1092
+1659	PF02537	CRCB		CrcB-like protein	Mian N, Bateman A	anon	COGs	Family	CRCB is a putative integral membrane protein possibly involved in chromosome condensation. Over expression in E. coli also leads to  camphor resistance [1]. 	22.70	22.70	23.10	22.90	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.59	0.71	-4.21	106	5746	2012-10-02 19:55:49	2003-04-07 12:59:11	10	8	3698	0	1390	3815	1350	112.50	30	83.00	CHANGED	hlhlulGGslGAhhRahlsthh.p.........................uTl.hlNllGsallGhhhs.hh..............htth...hphhlssGFhGuhTTFSoash-shplhpps.phh.tuhhahhholhhGlhsshhGhh	...................................lhlhlGGulGulhRahluhhhst...hhssh.................................PhGTL.hlNllGuFllGhhhshhh......................................tthssthphh.....lsTGFhGGhTTFSTFshEsl...p.L....h.pp.........s.....p.........h........h.....huh...h.al...hhollhul.hhshlGh.h..........................................	0	430	866	1175
+1660	PF01321	Creatinase_N		Creatinase/Prolidase N-terminal domain	Finn RD, Bateman A	anon	Bateman A	Domain	This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.87	0.71	-3.66	170	7541	2012-10-02 11:23:57	2003-04-07 12:59:11	13	18	4001	40	1991	5872	3626	132.50	18	31.80	CHANGED	Rlpclpphhpcps..lDuhllsss............tslhYloGa.........ssstshhl.l......st.cs..t.h...................llss.hchtpttppp...........hcl.h.hpp..................hpslhphltph.........h.t..............ppl.G...hEtsh.....hshst...hptlppth.....t...phhshss....hlpplRhl	.....................................+lpplpphhp..p..p..p.......lD..uh..llsss................................................tshtYlo..GF...................sssss.hs.l...l................st...-p...s...h.......................................................lhs..c...hch...httsppp.......................shpl..hthps........................................................hpslt..p.h.ltph..........................................................h.t................ppl..u..........h-..s.ph..............loh..st.....h..p..p.Lppth..........st.......ph.h.shs.......h.t.hR...................................................................................................	0	667	1256	1650
+1661	PF00030	Crystall	crystall; 	Beta/Gamma crystallin	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	The alignment comprises two Greek key motifs since the similarity between them is very low.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.58	0.72	-4.09	138	3340	2012-10-01 23:14:22	2003-04-07 12:59:11	14	52	213	141	1708	2532	18	81.10	31	53.48	CHANGED	+lplaEcpsFp..GcphEhs.sDs..sslpphhh.sc............lpSh+V.s.GsW.lhYEpssapG..cQalLc....pGEYtsapp.W.G.....ssp...........ltShRhl	....................................plhlaEcp.sFp....G.c.phEhs....s....Ds........sslps.h.....h...a.sp...............spSl+.V.s..G...sW....l..hYEpssap....G......pQa.lLc........p.G.-.Y.....p..a..pp...W..G........t.ss.p.........................ltShR.l.........................................	0	133	378	969
+1662	PF02633	Creatininase		Creatinine amidohydrolase	Mian N, Bateman A	anon	COG1402	Family	Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyses  the hydrolysis of creatinine to creatine [1]. 	24.40	24.40	24.60	24.50	23.90	24.30	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.52	0.70	-5.28	163	1362	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	981	81	528	1293	626	234.00	26	90.37	CHANGED	hsphoh..s-l.pph.....tpt..sssllPlGu.sEQHGPHLPluTDshlupslupcsspphs................shlhPslsh......Gh..SscHh.s.....FP...GTlolsspThhsl.lp-lscSlt.ppGh++llllNuHGG..Nhshlphsscclptc............shhlhshsaaph..s..t........hhsthttptshHAGthETSlhLtl....tP....-hVchs+.............................ts.thhsht..thhhshthpc...hsssGshG...-sst..AoAE....+Gctlhcthscthsphlp	........................sh.-htth......tps.....sssllPlGu.sEQHGPHLPluTDshlupslu...pp..lspphs................shlhPslsh....................Gh.....u...c.Hh.s........................aP.....G.T.lolss.pshh..sh.lt-lscult.p.pGh...++...........llhlN................uHGG..........Nhss....l.pts...spclptc................................shh.h.h.h..h...s.a.h.ph....s.........................h.t..t.t..t.ts...hHAGthETSlhLtl....tP.-h.Vchsc............................h.t.t.hhp.h.t....sh.hhs..hthpp.....hsss.....G.shG...csst...Aos-......cGctlhpthspthsphl......................................................................................	0	165	359	459
+1663	PF03858	Crust_neuro_H		Crustacean neurohormone H	Finn RD	anon	DOMO:DM02710;	Family	These proteins are referred to as precursor-related peptides as they are typically co-transcribed and translated with the CHH neurohormone (Pfam:PF01147).  However, in some species this neuropeptide is synthesised as a separate protein. Furthermore, neurohormone H can undergo proteolysis to give rise to 5 different neuropeptides [1].  	21.00	21.00	21.10	21.00	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.00	0.72	-3.37	8	51	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	23	0	0	56	0	38.60	54	29.06	CHANGED	RSA-GaGRM-RLLASL+Gsu-o.sPLu-LpGA.E.uuuHPLE	RSApGaGRM-RLLASL+..u-s.sPlusL..s.E..ussHPLE..............	0	0	0	0
+1664	PF01147	Crust_neurohorm		Crustacean CHH/MIH/GIH neurohormone family	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	26.20	25.00	23.70	24.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.08	0.72	-4.67	45	264	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	93	1	38	277	0	69.90	40	61.43	CHANGED	plaDpsC+Gla.sRslFp+L-RVC-DCYNLaRcsplsotCRpsCFsNphFttClcsLhh.c.phccapphlphl.s	........................haD.sC+Gla.DRslFp+L-RVC-DCYNL..a..R..p..stlsstCRpsCF.........sNphFttClcsLhh..-..phcphtthlphl................	0	12	15	35
+1665	PF00525	Crystallin	crystallin; 	Alpha crystallin A chain, N terminal	Finn RD	anon	Pfam-B_97 (release 1.0)	Family	\N	23.20	23.20	23.20	23.40	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.29	0.72	-3.76	11	395	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	264	24	81	297	0	51.50	65	39.75	CHANGED	MDIsIQHPWhRRPhas..aaPSRlFDQhFGEHl.-uDLFPsh........sslSPaYh+...P.hhRhPS	..........................R.....u...LGP....hhPSRLFDQFFGEGLhEYDLLPhh.............SSTISPYYRQS.....LFR...oV...............	0	5	12	29
+1666	PF03783	CsgG		Curli production assembly/transport component CsgG	Finn RD	anon	COG1462	Family	CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.25	0.70	-5.25	61	1246	2012-10-01 20:48:06	2003-04-07 12:59:11	9	33	1090	0	274	845	586	190.90	30	65.37	CHANGED	tshshsth+hsluVhpF..cspou........at.s..........SshsssluptusshLlstLppo...stFsllERpsLpslhpEppl...............ssphssLpuAshllpGulspaspss.t.tsG........hphhGlhu......psphppshspVsLRlVslpTucVlhSspssuchtspshpsu..............................hhthhsu.suhhsscslslAlppAlpp..hVptl.s.th.tuhWp..sp	.......................................................................s..h.hsss+h.luVhph..pscou..............a..h.h........Sshsstlsppu.psh.....Llo.t.L..p..p..S....p.h..F.hsL.E..R..p..s..L.pslh.p.Epplhps.s..p............s.pph.l........psLpu.AshhlpGuI........h..s.......ap.spst..s.st.lG..............tphaGIhu...........................................ss.phpls.pht..VsL+lVsVsTu.Ell.S........sp.sutphh..phpss..............................h.th.htu....uhhsscsl.lslhpAlpphV.hl.s.Gh.p......s................................................................................	1	75	168	224
+1667	PF02599	CsrA		Global regulator protein family	Bashton M, Bateman A	anon	COG1551	Family	This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay [1].  In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis [1]. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes [2]. RmsA binds to RmsB regulatory RNA.	20.70	20.70	20.70	21.60	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.60	0.72	-4.24	137	1995	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1669	7	426	998	255	53.20	54	75.78	CHANGED	MLlLoRKhGEsIhI...G.D.-IpIsVlplc..Gsp....V+lGIcAP+slslaRcEl......YpcIppc	.............MLILTR+lGEolhI...............G.D...-l.sVT.VL..u.V+...GsQ....VRIGlsAPK-VuVHREEI..Yp+IptE...................	1	175	279	361
+1668	PF02554	CstA		Carbon starvation protein CstA	Bashton M, Bateman A	anon	COGs	Family	This family consists of Carbon starvation protein CstA a predicted membrane protein.\	  It has been suggested that CstA is involved in peptide utilisation [1].	25.00	25.00	28.10	27.70	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.31	0.70	-5.81	97	3680	2012-10-03 01:44:59	2003-04-07 12:59:11	9	5	2335	0	644	2537	205	319.50	39	60.88	CHANGED	h.sulhlllsulssahluYRaYupa.lup+lht.lDssRtTPAcphpDGhDYVPTs+h.VLFGHHFAuIAGAGPlVGPllA.AtaGaLPuhLWIllGslhuGAVpDahsLahShR+cG+SlGpls+cplGphushhhhlhshhlhllllAlhuhlVspsh..............sp...........oPh.....................ushslhhsIPlAlhhGha...hah+suplhtsSllGllLlhhulhhGhh.ls........................................hh.hstpphsh..llhsYualAolLPVWlLLtPRDYLooahhluslshLslGlll.....stPplphP.AhTp......F.h...sGssPhhsG...slFPaLFITIACGAlSGFHuLluSGTTsK.lspEscs+hlGYGuMLhEuhlAlhAllAAsslt....................uhYauhp......................................................................Ghs.....sstlsphup....slG	............................pshhhllsulshhhluYhhYuha.l..tpplh..l.-..ss.R.hTPAhh.sDGhDYVPss+h.llFGHHFuu..IAGA.GPllGPlLA.A.hGalPuhlWllhGslhAGAVpDahsLhlShR+sGtSluphhpcphG.hsthlhhhhshhlhlllhAVhu.....h....llspsL................s.t............sPh..................................................uhhs.lh.hlslAhhhGhh...hhhts...sp..hh.hohlGhhhh.hhslh.G...l.........................................h.hptsthsh..hlhsYsFlAulLPVWhlLuPRDYLsoahhlssllul.sl.Glll...................htPpl..p...hP...uhop.....a.h................ssssP..h..hsu............slFPhLFITIACGAlSGFHAhluSGTTsKhlt.............pEppuphlGYGuMlhEuhVAlhAhluAs.h.l.........su.hh.th...............................................................ht.s..hh.............................................................................	0	219	401	536
+1669	PF00859	CTF_NFI		CTF/NF-I family transcription modulation region	Bateman A	anon	Pfam-B_362 (release 3.0)	Family	\N	19.50	19.50	20.10	19.70	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.12	0.70	-4.65	4	440	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	51	0	132	328	0	227.10	51	56.35	CHANGED	QDSFVTSGVFSVoELVRVSpTPIssGTGPNFSLuDLpSpsYY.shsPGu..hRRoLPSTSSSuS.KRhK..SME--hD.SPGt-saYo....SPuSsopSS.sWHE.hEsuhsSP.phpc.-Ks.FsssSPpppSshhSuFsQ+H+Psl.....os.tsSPHso.SsLHFPTSsIl.QpPuoYFsHsAIRY....pPQ-sLK-aVpLsCssuuQQuGQ.....PNGSuQ..GKV.s.FLsTPMLsPPPP..PshARPVsLshPDTKPsTTSTEGGusSPTSPoYSsPuTSPANR.FVulGPRDPuFl...pQsQSWYLG	...............................................pDsFVpSGVFsVoELVRVSpTPlssGo.....GP.NFSlu-.L...pSp.sY.Y..s....hss......u.....s.....h+RSLsSssSo............ss.K........R...K.........Sl-.-.pM-...SPst-..........FYs....SPu...ususu.S.t.sWp-..h-.............s.................s.............h......su.P....ssh....KKs.tK...FsS.sosppsSshh.sFspHt.hPs..l.....ss.....ssSP+so..sSsLHFPoosIl..QpsusYFoH...PsIRY...hpP.QDsLK-aVphsCs..s.u..u.tQ.s.u.p.........................suusQ...+h..s.h....hLsPs........P.......h.h............................t...........................................................................................................................	2	9	23	64
+1670	PF01467	CTP_transf_2	Cytidylyltransf; 	Cytidylyltransferase	Bateman A	anon	Bateman A	Domain	This family includes: Cholinephosphate cytidylyltransferase Swiss:P49585. Glycerol-3-phosphate cytidylyltransferase Swiss:P27623.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.99	0.71	-4.17	65	14199	2012-10-02 18:00:56	2003-04-07 12:59:11	21	74	4889	196	4168	10545	6936	142.60	19	60.12	CHANGED	lhsGoFDPlHhGHlpllcputphhs......llhlssspsspp..p....shhstpcRhchlctshtsst.....................................................h.hlhstc.....................hpthpchltchphshhs+s.s..thpt.....................t.....hhhhhhh.htp.......lSootl+pt	.......................................................................................................lhsGoFDPlH..h.........GHl.shlppA...t......p.....h......h.......c.........h..........................llh..ls....s.s..t....s..s..p.+...p............................shh.s.h.ccR....hth....l....p....t......s....h......t.....s........................h...........h.......p.......................................................................................................................................................................t.......h..hl..h.ttc.........h...........................th..p..th....p..c..h..h...t......p...h......p.....h...s...h..hs..+.s...t...th.pt.h..........................................................................................h..h.........h.................lSoo.l+p.h........................................................................................................................................................................................................................................	0	1392	2560	3483
+1671	PF02348	CTP_transf_3	Cytidylyl_trans; 	Cytidylyltransferase	Bashton M, Bateman A	anon	Pfam-B_886 (release 5.2)	Family	This family consists of two main Cytidylyltransferase activities: 1) 3-deoxy-manno-octulosonate cytidylyltransferase, [3], EC:2.7.7.38 catalysing the reaction:- CTP + 3-deoxy-D-manno-octulosonate <=> diphosphate + CMP-3-deoxy-D-manno-octulosonate, 2) acylneuraminate cytidylyltransferase EC:2.7.7.43, [1,2], catalysing  the reaction:- CTP + N-acylneuraminate <=> diphosphate + CMP-N-acylneuraminate. NeuAc cytydilyltransferase of Mannheimia haemolytica has been characterised describing kinetics and regulation by substrate charge, energetic charge and amino-sugar demand[4].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.47	0.70	-4.71	20	4289	2012-10-03 05:28:31	2003-04-07 12:59:11	14	33	2780	54	1074	4236	6196	213.60	26	80.94	CHANGED	lsIIPARhuSpRL.sKsLtpltGcPllt+slcsAhpSthh-+....llVATDscpltchsppaG..spshhpssshsssscRshcslcchhss........hllslpGDpPhLpspsltphhppltps.t...................hsshstsls.sppshpssslcsshcpp......shthahpcushsahpcp.s.................hhtchulYsaRpt....hhhcaststsos...........hc.hcpl.........cQh+.....hhhtu................pcI	.......................slIPA.Rh...uSoR..l...P.....s....Ks...Lt....c...l......s...G.....K.....P..hIhash.-...p....A.....t...p.u....s...t....h.c.c.........l.l..V...A...T.....D....c...c...c....l....t....p....s....s......p....t.hG..........scl.h..h.s....p...s.c..p.t....o....u....o.....c.......R....h....s...-..s....l..p.c...hshs.....tp....................llls..l...Q.G....D..p....Phlssshlpp....sh..p...t..l...t..ps...s...........................................................th.s.o...h...s...h.........l....t........t....t....p........c...h...h..s........s...s.s......l.K...s....l....h..ctp..................s.u...h...a...a.o+ss..lPa....+....p.t...t.....................................................hh.t+..l.u...lYsactt...........hl.pas.t.....s....................hE.hE.l...................-ph+.....hh.....................................................................................................................................................................	0	335	680	894
+1672	PF04808	CTV_P23		Citrus tristeza virus (CTV) P23 protein 	Kerrison ND	anon	Pfam-B_2595 (release 7.6)	Family	This family consists of protein P23 from the citrus tristeza virus, which is a member of the Closteroviridae.\	 CTV viruses produce more positive than negative RNA strands, and P23 controls this asymmetrical RNA accumulation. Amino acids 42-180 are essential for function and are thought to contain RNA-binding and zinc finger domains [1].	20.70	20.70	21.00	20.70	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.44	0.70	-5.01	3	175	2012-10-01 20:03:16	2003-04-07 12:59:11	7	1	1	0	0	178	0	204.80	91	100.00	CHANGED	MDNTSGQTFVSVNLSDESNTAST-VEsVSSEADRLEFLRKMNPlIIDALIRKNSYQGARFRARIIGVCVDCGRKHDKALKTERKCKVNNTQSQNEVAHMLMHDPVKYLNKRKARAFSNAEMFAIDLVMYTKERQLAVDLAAEREKTRLARRHPMRSPEETPEHYKFGMTAKAMLP-INAVDVGDNEDTSSEYPVSLSVSGGVLREHHFI	......MDsTSGQTFlSVNLSDESNTASTcV+sVSSEADRLEFLRKMN.PFIIDALlRKTsYQGARFRARIIGVCVDCGRKHDKu.+TERKCKVNNTQSQNEVAHMLMHDPVKYLNKRKARAFSNAEMFAIDLVMYTKERQLAVDLAAEREKTRLARR.HPMRSPEETPEHYKFGMTAKAMLPDINAVDVGDNEDTSSEYPVSLSVSGGVLREHHFI......	0	0	0	0
+1673	PF01179	Cu_amine_oxid		Copper amine oxidase, enzyme domain	Bateman A, Finn RD	anon	Prosite	Domain	Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ). This family corresponds to the catalytic domain of the enzyme. 	19.70	19.70	20.10	21.40	19.50	18.30	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.16	0.70	-5.75	75	1272	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	545	187	699	1240	205	371.60	33	57.94	CHANGED	Plpl....sQP-GsSFpl.c.....GptlpWppWpF+lGFssREGlsLaslpapscs.........lhYRlSlsEMhVPYGDPpssahpKpsFDsG-aGhGhhussLplG......CDChGt.IpYhDuhhssssGpPhplcNulClHEpDsG.lLaKHoshcs..s.ps.tspRsRpLVlphIsTluNY-YhahahFhpDGsIchEl+ATGIlsoss........hss.....spp.....ss...aG.shVs.sslhushHQHlFshRlDhslDG...t.p....Nolhth-shshsh.......sstN..Phusuapsccphlcsttpu..thchssppsRhaclhNssppN.h.GpPsuY+lhs......ssssh...llspssShhtpRusFAp+plWVTtYc-s.....EhauuGpassQssus......sGlssaltp...scs.......lcspDlVlWaThGhpHhP+sEDaP..VMPs-hhuhhL+PhsFFspNPuLDlPsssp	...........................................PhplhpPcGssapl..p......Gphlp.WppWpF+lu..hs.RtGhhl.slpapsps...........lhYchSlsEhhVPYu..sPp....sahh+thhDhG-aGhGhhsssLthG.................pDC..u.t.h.....tahDs.hhss.t...sGtPht.h...su.....lClaE...p....s.sG..ha+...Hppht...............t...s...hstcp+pLVlphlsTluNY-Y........h...........asahFtp...sGsI......phcspuTGllssts.......................hss..t..ts.....s....aG.ohls...slhushHpHha......shRlDhsl...D....G...........t...p....N.o.lh.t..-.s...hs...h.s....................sst..s..s.h.....s...ssh...p...sp...pph....lpsE.tpu..thch...sstp.sRhhhlsNss.ppNth.Gps.........suY+lhs......ss.st.h....hhhs.ss.s.h.hh.+R.ssF.sc..................pp....laVTpY..ccs......E.....hasuGtassps.ts..............suls.paht..p......scs..............................l.....c...s..p...Dl......VlW...hT..................hGhpHhP+s..EDaP..lM..P..s..p..hh..sh.hL+PhsFFspsPslss........................................................................	1	162	358	544
+1674	PF02727	Cu_amine_oxidN2		Copper amine oxidase, N2 domain	Bateman A, Finn RD	anon	Prosite	Domain	This domain is the first or second structural domain in copper amine oxidases, it is known as the N2 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.76	0.72	-3.90	14	944	2012-10-02 11:54:05	2003-04-07 12:59:11	11	27	479	119	492	882	81	87.20	27	12.37	CHANGED	HPL-sLostEhs+spsIlpsps.hsts.shphp.lsLc-PcKphVhpa.....-ctssh..ssRcApslhhhuups..a.hllDLssuplsusphh	................................HPLssLostEI..pp....sst.llp........sut.................hts........s.....h........pFttlsLtEPsKttlh...sa................stssts........ssR..pA......l....l..h..h...s.....t.p........hcslV-..L..ssstl.p.p..h............................................................	0	103	248	379
+1675	PF02728	Cu_amine_oxidN3		Copper amine oxidase, N3 domain	Bateman A, Finn RD	anon	Prosite	Domain	This domain is the second or third structural domain in copper amine oxidases, it is known as the N3 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).	20.60	20.60	20.60	20.70	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.13	0.72	-3.96	17	943	2012-10-02 11:54:05	2003-04-07 12:59:11	11	20	497	180	473	884	97	100.70	23	14.32	CHANGED	sslhhcEhspsppllh..p.Ptatcslpp+G..tp.hspVhstPhosGaautts....ucRlh+shsahppsss....shas+Pl-slplllDhcshcVlchp-pt.hhsls	....................................lhh--atplppllp..ss.spatts.l..ccp..G...ls..s..hp.pVhssPh.s............s..........G..........h....hstps......spRlh.pslhahcssss........Nhau+Pl-.lsslV..D.hpptcllcl.c.t..hhsh.................	0	93	229	354
+1676	PF02298	Cu_bind_like		Plastocyanin-like domain	Mian N, Bateman A	anon	Pfam-B_398 (release 5.2)	Domain	This family represents a domain found in flowering plants related to the copper binding protein plastocyanin. Some members of this family (eg  Swiss:P93328) may not bind copper due to the lack of key residues.	20.80	20.80	20.90	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.14	0.72	-4.19	26	1166	2012-10-02 17:41:00	2003-04-07 12:59:11	12	16	93	17	688	1154	2	82.90	31	43.81	CHANGED	Wshsh......YspWAsu+pFplGDsLlFpYssphHsVhcVs.ctsYcsCpssp.shpsas.............sGssplsLsp.GhpYFICuhs..GHCp..tGh	..................................sYssWu.ps..p.p.F.p..lG.DsL............l.F.pY.......s......s.....s...........a....s..Vh.pVs....cssYcsCssss.....sl..t.s.h.s............................sG..s..s..t.l....s...L....s..p...s.G.tt.Y.F.I.suhs.....uHCptG............................	0	76	388	550
+1677	PF03263	Cucumo_2B		Cucumovirus protein 2B	Mifsud W	anon	Pfam-B_4373 (release 6.5)	Family	This protein may be a viral movement protein.	20.90	20.90	41.70	40.80	20.60	18.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.55	0.72	-3.74	7	122	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	9	6	0	124	0	104.60	70	96.29	CHANGED	tuuhosl-LpLA+lVEtK+pRRRSH+pNRRtRGaKSPSERARSpLR....LFphLPFatsDss-.hhshh+c.shs-LspsEss.....s.p.tshDDTDWFAGNEW.sEGSF	......t.GAhTNVELQLARMVEsKRQRRRSHKpNRRERGHKSPSERARSNLR...........LFRFLPFYQVDGSE.Lh...-hh+HssVsELsESEAsp.h..ut-DHDFDDTDWFAGNEW.AEGuF...	0	0	0	0
+1678	PF00760	Cucumo_coat		Cucumovirus coat protein	Bateman A	anon	Pfam-B_867 (release 2.1)	Domain	\N	25.00	25.00	49.30	43.20	18.60	16.70	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.13	0.70	-5.38	4	531	2012-10-04 01:49:40	2003-04-07 12:59:11	13	2	37	6	0	462	0	188.50	85	95.29	CHANGED	sstpRRPRRGpRS....sssutDtsLRALTQQlsRLsphhAuutPTLsHPTFVuSc+C+sGYTaTSlsl+Ps+hEKsp.FGpRL.LPssVoEYsKKhVSplQlRlNP.PKFDSTVWVTlRKlPtoosLostul.thFsDGhSsVLlYQassoGlQsNNKllaDLSshtA-IGDMpKYAllVYSKDDsLEsDElVlHVDlEHQRIPouphL	.............sRRRRPRRGSRS....AsSSADAsFRVLSQQLSRLNKTLAAGRPTINHPTFVGSERCKPGYTFTSITLKPP...KID+GSYYG...KRLLLPDSVTEaDKKLVS.RIQIRVNPLPKFDSTVWVTVRKVPASSDLSVAAISAMFADGASPVLVYQYAASGVQANNKLLYDLSuMRADIGDMRKYAVLVYSKDDALETDELVLHVDIEHQRIPTSGV.L.....	0	0	0	0
+1679	PF02376	CUT		CUT domain	Mian N, Bateman A	anon	Pfam-B_770 (release 5.2)	Domain	The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein (eg Swiss:P10180).	22.50	22.50	22.50	22.80	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.78	0.72	-4.18	26	1069	2009-01-15 18:05:59	2003-04-07 12:59:11	10	15	90	11	655	873	0	84.90	35	19.88	CHANGED	sphssspplsTtcIscclcpcL+...................ctsIuQslFAchlLs...+SQGoLS-..LLp............cP.......KPWsphp.pG+psap+MppaLs.s..psp+thhhh...ppp	.................t......pplsTtcIspcl+.ppLp...................+tsI..sQtlFuchlL..s...hS.Q.......GolS-..lLp.........................cP..............KPWs+Lp..pG+EsFh+MppaLptsps.+..hh....ph...........................................	0	96	146	428
+1680	PF00888	Cullin		Cullin family	Bateman A	anon	Pfam-B_1149 (release 3.0)	Family	\N	23.00	23.00	23.00	23.20	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	588	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.84	0.70	-5.98	47	2251	2009-09-12 05:56:55	2003-04-07 12:59:11	17	46	329	30	1484	2160	44	484.10	20	65.66	CHANGED	Wstlp.ss.....lp..plh..............t......h..laptlhsh............................................p.hut...lYpthtp....hh.........ppaltt.h.tph.t.....................t...hl..h...t.W..a...h.hhtt.hh.a..hs..p.a.ltpp.........................h.h..apt.l.ht...htt.hh..hh..h.....R..p.....p.....htthhp.hh.h........................t..hY.p.Ft..hlptottaYp..s.thl.p..sh.pYh..s..thppEpppst.........alp.ps.t...lhthhpp.hltth.t.l......tth..hhttpp.pcl..ha.lhphh.tslp....hhthhpphlp..ptuhthhtp.........................................................................................t.ps.....hlpthlthht....hhppsF.t......c.....hhtslppsht.hls.t.....................spssEhluhahD.hL+put....pthsptp...................lcpplsplhhlhcalpsKDlFpcaYpphLA+RLlptpSss..-sEpphlstLKp.............................ttG.paTp+lptMhpDlplSc-lsppFc.phhtpp.t..........................................................shshslplLssshWPh.ssp...............hplPp.....clppthctFppaYppp+ss........R+LpWhhpLupsclphph.ttt...........................................h.hploshQhslLhhFNp...............pcplohc-ltpttplstc..tLpc.tL.pslhpsphhh............p..pspphssssthplNppas	.......................................................................................................................................................................................................................................................................................................................................................................h............h....h.................................................................................s......lat..h.............h..........................th.h..t................................................................hl..h.......Wt..pa....................h.h..t......hh.h...h....s...p......h...h.tp.....................................................................................................................................thhh..apt..h..h................h.....t......h.t.............h......h..............lt...p..................R....s........t............p............h..th..h.t.h...................................................................................ha.....ac..hlt.stt.hat..s..................h.t........h.....ah...........s..th.l..pE...hh.................h.h.........t...................l..t.h.p.hl..............t..h.........................tth.....h...h.....t.........t.........t.......p...........t...............p......l...t....h...a......h...h...t........t.............h.............t.......t........h............h..h.t.ht.....thlh..p.u.thh.t...................................................................................................................................................................h...ltt...h..lp...hh.p.p.h....t.h.....h..t........sFtt...........................................p.......h....t.shp.p...s....h.t...h.ls.t............................................................spssEh..l..........u..ha.......h.D...hl+ts....................tp..p........................................................................................................................hcp.h....h.pp...........hhh.l...h..p.hl.....p.s.....KDlF.paYpp.hL.ucR.L....l......................t.....p..........o.....h................s...............-..............t........Etphl..p.h..L+t..................................t.h.G.....p.h...s.p.p.hptM.hp.....Dh.p.h.S..p.ch..t.p.app....h.htpt.........................................................................................................................thphph.lLsts.......h..W..Ph............................................htlP..............phtph.hp.ap.pa..Y..t...ppss...........................R.+L..pW......phupsplp..hp.h...t.t.t........................................................................................................hph..p.loshQ....hhlLh.h....FNp..................................tp.p..ho.hppltp.....t..s.....t..l.....t.....Ltp.tl...t.l...h...p.tthh.........................t.......................................................................................................................	0	530	800	1185
+1681	PF03091	CutA1		CutA1 divalent ion tolerance protein	Mifsud W	anon	Pfam-B_2307 (release 6.4)	Family	Several gene loci with a possible involvement in cellular tolerance to copper have been identified [1]. One such locus in eubacteria and  archaebacteria, cutA, is thought to be  involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognised structural motifs [2]. This family also contains putative proteins from eukaryotes (human and Drosophila).	22.10	22.10	22.20	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-4.35	13	1667	2012-10-01 21:59:08	2003-04-07 12:59:11	10	8	1551	85	550	1191	568	99.10	39	84.17	CHANGED	hhllhlTsPs.-pAcclA+pllEc+LAACVNllspIcShYhWEGcIpcDsEhhlIlKTpspphspLpccl+phHPYsVPEIluLPlppGspcYLpWlcpslc	..............h.hlVhsTsPsc.ts.ApclAttllp..c+LAACsslls.shpSl...YhW.....c.....G.....+....l.....cp-.t.ElthllKTss..sphpsLhcpl..+phHPYpsPEllslPlsp..GsssYLsWlstsh.p.......................	0	154	313	430
+1682	PF03932	CutC		CutC family	Bateman A	anon	COG3142	Family	Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	21.20	21.20	21.30	21.60	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.36	0.71	-5.06	8	2302	2012-10-03 05:58:16	2003-04-07 12:59:11	9	10	2140	20	426	1510	277	197.20	39	85.23	CHANGED	hllElCl-slsulhsApsuGA-RVELCuuLulGGlTPShGllcsAsc...pusIPlasMIRPRGGDFlYs-pElcsMtpDlcss+chGssGlVlGsLsscGslDhcthcpLltAAp..GLuVTFHRAFDhssD..PtcALEpLIcLGs-RVLTSGtt..ssAl-Gh-pLtsLVsQAusRIpIMuGAGlsApNltcLsptTGlsElHuSuts	.....................................................h.hlElCsts......hpsshpA.t...psGAcRlELC..s..s..h.s...G.GlTPSh...G....llcp.s...hp.......................ph.sl...P.lhshIR.PR.....u...........G..............D......Fs.......Y..s-tEhth.MhcDlphs+c..h...........G............s........s......GlVhGsLss...-.G.............p...........l........Dh.....s.th.cclh.s.......s.u..t..................sh..s....l.....TF.HR.....A.FDh..s......s..s................h...p..A.....lc...p.......L.h....p....h.G...l.s..RlLTS..........Gtt....sss.....p..u..l.sh....l.....pc.L.....l......t...p.....u....s.........u.........p.............I.............Ihs...........Gu.GlpscNlpphh.c.......sG.lpplHsot.s............................................	1	136	238	337
+1683	PF01083	Cutinase		Cutinase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.17	0.71	-4.54	23	1537	2012-10-03 11:45:05	2003-04-07 12:59:11	17	11	503	75	597	1612	26	189.00	24	66.18	CHANGED	ssCscltllFARGosEsush...ussGsshsssLputhGusslul.uVt..YsAshsp........tsosssGssshtshlspssspCPsTplVluGYSQGuplhssAlst..............lsuustspltuVllFGsPps........spsls.......................slssh.suK..shshCssuDslC..usuhshss....Hh..sYss-.h.sspAssFlts+ls	........................................................s..C.sh.hhhA.RGot..-...........s.....s..........s.......h..........s.........h.s.......s....h.h...s.sl......p......p...p.h.....s...........p..s.l...ssh..s..Vs........Ys..Asht.........................t..os.stGs...p.s.h........sstl.....pp.h......s......s..p.....C.P.s..T.....clVLuGY.....SQGAslhstshss...................................................sh.s.s.s..s...s..s..+.l...su..l....sLaGs.Ppp..........sts.hs.................................................................shs..s...h..s..s.+...s....hplCs.s....u..D..sl.C.......ss...................s.............H.....Y...........u..hh.................................................................................................................	0	135	324	513
+1684	PF01473	CW_binding_1		Putative cell wall binding repeat	Bateman A, Mistry J, Russell R	anon	Bateman A	Repeat	These repeats are characterised by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins.  The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls [1]. Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding [2] as well as in the related dextransucrases of Leuconostoc mesenteroides.  Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known.	20.50	9.80	20.50	9.80	20.40	9.70	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.74	0.73	-6.64	0.73	-3.57	213	28133	2009-09-16 13:19:13	2003-04-07 12:59:11	15	543	547	186	1455	18171	72	18.80	40	20.20	CHANGED	suWhp.h..s..ssW.YYh.sssGsM	............sGWhp.......s...upW.YYh..sssGtM........	0	419	1058	1118
+1685	PF04122	CW_binding_2		Putative cell wall binding repeat 2	Kerrison ND, Finn, RD	anon	COG2247	Repeat	This repeat is found in multiple tandem copies in proteins including  amidase enhancers [1] and adhesins [2].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.12	0.72	-3.78	99	3897	2009-01-15 18:05:59	2003-04-07 12:59:11	7	210	151	0	926	3881	25	92.20	26	35.86	CHANGED	pRl.sGss...RY-Tuhp....lupp..........h..........h..sssslhl..s....sG....ps..asD.ALuuuslAup............pssPllLss....ssh...psstshlpsh...........t.pplhll..GGpssls...pp....lhpp	..............................................Rl.uG..ps...Ra-Tuhp....lucp.....................h.t............................t.....sssp.lh.l..s.............sG...........ps......hsD..ALuuuslA.sp..............................t.s.u..PIlLss.......tssls....ssstshl.pph.........................tspplhll..GG..p.sslsppl...t...........................................	0	554	857	897
+1686	PF03638	TCR	CXC;	Tesmin/TSO1-like CXC domain, cysteine-rich domain	Bateman A	anon	Pfam-B_1144 (release 7.0)	Domain	This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin Swiss:Q9Y4I5 [1] and TSO1 Swiss:Q9LE32 [2]. This family is called a CXC domain in [2].	20.30	20.30	21.20	20.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.62	0.72	-4.10	90	900	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	139	0	617	883	19	40.70	48	14.71	CHANGED	ppp+sCsCKKSpCLKhYCECFtsGthCsp..CpC.psCpNptpp	...............pp+sC.sCKKStC...LKhYCECFt...........uu..hhCss...CpC..psCpNp........	0	297	406	520
+1687	PF03128	CXCXC		CXCXC repeat	Bateman A	anon	Pfam-B_252 (release 6.5)	Repeat	This repeat contains the conserved pattern CXCXC where X can be any amino acid.  The repeat is found in up to five copies in Vascular endothelial growth factor C [2]. In the salivary glands of the dipteran Chironomus tentans, a specific messenger ribonucleoprotein (mRNP) particle, the Balbiani ring (BR) granule, can be visualised during its assembly on the gene and during its nucleocytoplasmic transport. This repeat is found over 70 copies in the balbiani ring protein 3 Swiss:Q03376. It is also found in some silk proteins [1].	13.20	13.20	13.20	13.20	13.10	13.10	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.42	0.74	-6.50	0.74	-3.42	116	305	2009-01-15 18:05:59	2003-04-07 12:59:11	9	19	71	0	133	258	0	13.90	43	10.39	CHANGED	sphWscpoCpCtCs	....sppaDcsoCpCsC..	13	46	52	85
+1688	PF02560	Cyanate_lyase		Cyanate lyase C-terminal domain	Mian N, Bateman A	anon	COGs	Domain	Cyanate lyase (also known as cyanase) EC:4.2.1.104 is responsible for the hydrolysis of cyanate, allowing organisms that possess the enzyme to overcome the toxicity of environmental cyanate. This enzyme is composed of two domains, an N-terminal helix-turn-helix and this structurally unique C-terminal domain [2].	25.00	25.00	25.80	32.60	24.80	20.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.45	0.72	-4.44	25	725	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	688	80	229	524	63	73.00	59	47.15	CHANGED	shp.slPoDPhIYRhYElVhVYGsolKplIpEcFGDGIMSAIDFsh-l-+.psPc.GD.RVVlThsGKFLPY+pa	........sh...stlPTDPslYRFYEhlQVYGsTlKALlHE+FGDGIhSAIsFclDVcKlsDPc.G-.RsVITLcGKaLPhKs......	0	59	131	184
+1689	PF04199	Cyclase		Putative cyclase	Bateman A	anon	Pfam-B_1440 (release 7.3)	Family	Proteins in this family are thought to be cyclase enzymes.  They are found in proteins involved in antibiotic synthesis.  However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	20.80	20.80	20.80	20.90	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.41	0.71	-4.57	76	2705	2009-09-13 14:05:17	2003-04-07 12:59:11	8	22	1704	5	1053	2458	695	168.90	21	65.07	CHANGED	lhDLohslp..............pt.h........shh............h....................tt.hsh...pt....shsspt.lp.h.ssHsGTHlDu.sH........h................s.................sl-plPlp....hhs.pulllDlsp.................hsst-lptshpt.th...plptu-hVll+T......................Gh.................tphh..sstp.ahsp..........PGlsh-uucaLh.cpGl...pslGhDshuh...........-ts.	.........................................................................hDlo.shp..................t..h........shas...........htht.h............................................tt........tshtspp..lp.h..ssp..s.G..THhDAPhH.........................................................h.tsst.........................................sl-p.l.slct.............hhu.......ulll..Dhsp.....................................ssthl.shpclt..tthtt.th.........pl.pt.u.c.hVll+T..........................................uh.......................................pp...hh...............s...s..tp...hhps................hs.uh....s.......-........ss..caLh....-..p..sl......pslGhDshuh-...s..............................................	0	330	674	904
+1690	PF02984	Cyclin_C	cyclin_C; 	Cyclin, C-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.	21.20	21.20	21.20	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.72	0.71	-4.17	240	3032	2012-10-03 00:42:12	2003-04-07 12:59:11	14	43	449	158	1706	2961	42	116.40	20	28.12	CHANGED	PTshsFLcR....h.t+...........s...sph..................s....p........hcplupalhE......Lolh-ap............hlpahPShlAAuA..lhlupph......Lt.....t.............WspsLptao.uY...stspLtsssphlh....phhh...pss.....tsph.p..ulhcKYsppchtp.........lu.hhss.	..............................................................................ssshpFLpp........h..h+................h.........sph...........................s..p..........hcphupahhE........................lol..h-hp..................hlp.a.PS.hlAAuu..lhhAtph.......lp....t...................................Ws.p..p..l..t..t.ho..sh.................s.p...p...l..t......s....s.hp...hlh..phh............p.....................thhp+ht...............h.......................................................................	1	471	819	1258
+1691	PF03784	Cyclotide		Cyclotide family	Bateman A	anon	[1]	Domain	This family contains a set of cyclic peptides with a variety of activities. The structure consists of a distorted triple-stranded beta-sheet and a cysteine-knot arrangement of the disulfide bonds [2]. Cyclotides can be separated into two subfamilies, namely bracelet and moebius. The bracelet cyclotide subfamily tends to contain a larger number of positively charged residues and has a bracelet-like circularisation of the backbone [2]. The moebius cyclotide subfamily contains a backbone twist due to a cis-Pro peptide bond and may conceptually be regarded as a molecular Moebius strip [2].	20.30	20.30	20.50	20.50	17.20	19.80	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.22	0.72	-4.07	30	259	2009-09-11 23:07:15	2003-04-07 12:59:11	8	4	30	33	0	274	0	29.80	57	44.52	CHANGED	G..lP.CGESCsalP.C...tssG.CSCcs+...VCYhN	.......GlP.CGEoCVhhP.C...sshG.CSCpsp...VCY+N..	0	0	0	0
+1692	PF00548	Peptidase_C3	Cys-protease-3C; 	3C cysteine protease (picornain 3C)	Bateman A	anon	SCOP	Family	Picornaviral proteins are expressed as a single polyprotein which is cleaved by the viral 3C cysteine protease.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.45	20	4118	2012-10-02 13:45:52	2003-04-07 12:59:11	15	54	450	68	1	3087	3	135.60	48	11.78	CHANGED	GPsh-F....uhuhh+pNlhslsT...........spGcFTtL..GlaDplhV.....lPpH..upsscsIhlsGppsplhD....uhpL.lcppGssLElTllpL..cR...NEKF.RDIRpals...pphpcts-ssLslNosphsphhlsVGpVsthGhl.sLuGssTpRsLhYsaPT+sGpCGGVlhs....sGKllGlHlG.GNG	...........................................................................................................................................................P..-h..thhht.Nh.h.sph...........tp.s...h.h.hh...G..lhsphhl.....lPpH........ut.h...plhh.....p..t...t...hph.-.........thtl...stpsh......h.....-lsllpL..cp...s..p+F.RDIptals............pp.s.t..h..sss..shhl.......s.s....pc.hss..hh....l..s.l.us.....ls......G...h...l......s...hs......G.......p............o..t.+...h...hhYp..a..s.T+....A.GQCGGVl.h.u...........s.GKllGIH.lG.GNG...........	0	0	0	1
+1693	PF00007	Cys_knot		Cystine-knot domain	Sonnhammer ELL	anon	Published_alignment enriched with PDOC00234 members.	Domain	The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins.  It is believed to be involved in disulfide-linked dimerisation.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.85	0.72	-11.43	0.72	-3.95	24	1416	2012-10-02 16:54:34	2003-04-07 12:59:11	17	22	417	7	416	1343	0	92.30	29	44.70	CHANGED	t.hCp.hN...hTlplE+csCshClslpTTICsGaChTh-...sh.ssh..h.QplCsac-hpYcohclPsCPsGssPhhoYPVAhSCcCs..tCstssoDCsh.thpsshC	.......................h...C..hp.......hsht.h..ch...p..t...Cs.s..h.shp.sshC.GhChp.........................s....s.....t................p..sC..shtchph.psshl.......sCP...s.....G......s.s...s...h...h..o...ash...sh...oCpCs...tCpts.ss.h...........................	0	44	77	214
+1694	PF01053	Cys_Met_Meta_PP		Cys/Met metabolism PLP-dependent enzyme	Finn RD, Bateman A	anon	Pfam-B_366 (release 3.0)	Domain	This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase,  O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.10	0.70	-6.18	30	12248	2012-10-02 18:26:03	2003-04-07 12:59:11	15	41	4308	161	3561	25261	14126	368.30	34	93.53	CHANGED	sThtlHuGpp.c...spuAlssPIYtoooatas........tsscpsG.a.YoRpGNPTpssLEcplAtLEuu..stulAhuSGhAAl.sslhsLlcs.GDc.....llsssslYGG.....Taphhcpshs+.hGlpssaVDs....schsslcpAlps..sTKhlalETPoNPhhclsDIttluclA+cp..s..llllVDNTFsoP.hlppPLcLG..ADlVlHSATKYlsGHuDVluGlllsps.tclspchthht........................................sshGusluPaDuaLlhRGl+TLsLRhcppspNAhplAcaLcpc....P....pVcpVhYPGLsoHPpH-lA++QhpGhuu..hlSFclcus............tupchlcsl+LhohAtSLGusESLlptPAsMTHuslstEpRtstGls-sLlRlSVGlE-h-DLlsDLcQALc	.............................................................................................................................Thhl+uG..p.c.............tt.su.hssPI..a.o................ooa.h.....as.........................................................................h..........h..........t..........p........t..............t.......G.....h...............Y.o...R...h...s.......N................P...T....p...p...s...l....E.....p....t....l..A.t.......L..........E..........G.....G..............t.....s...........u..........h.........s....h...u........S........G.................h.....A.......A....l.............h......s......l.....h.....s.......l.........h.......p....s.....G..D....c.......................l...l........s........s........s........s.....l.........Y......G...G............................T.h...p...l.......h........s.......p.......h......h........t.......+.......h......G...........l......p.........s.....s.......a...l.....D..s.......................s...s......h......p.......s......l........p.......t.....s.....l....p........s............p......T.............K.............h.....l............a.....l....E.....o....P.......u....N....P.....h....h............p....l...s....D...l...t...t....l....u....p.....l.....A.......+...pt..........u...........h........h.........l........l...........V.........D............N.......T............a.........s..........o...............P......h.......h............p..........p.........P.......l......c........h...........G..........A......D.....l.......V..l..H..S..u....T..K..........Y..l........s.G.....H..u..D.s....l.......u..G....s.l.l...s....s........s...................p...ht....p...p..h..t..h..h..t....................................................................p.s.h.G....s....s....l..u...P...h...s..u...a....L......l..l..+.G...L....c....T....L...s....l...R....hc...p.....p...s....p.N..A.....h.p.l.A....c..a.L...ps..+.....................P.........................tV.p...p..V....hY...P........u......L.........................s.......p..............t.....a......p.....l...t..p............+.......................h...........p..............G................t.........u.......u...........l..lSFplcss.....................ttstphl....ssL....c....l.h.s....hutS.lGsscS.L.l....h..a.....P.....u...s.....h....T..H......s....p....l.....s...t..c.....t.....p.....t...t..t..G.........l..ss.sL..lRlSlG.lEc.s-.DLlsDLcpAL.t.........................................................................................................................................................................................................	0	1060	2191	2996
+1695	PF00839	Cys_rich_FGFR	cys_rich_FGFR; 	Cysteine rich repeat	Bateman A	anon	Pfam-B_297 (release 3.0)	Family	This cysteine rich repeat contains four cysteines.  It is found in multiple copies in a protein that binds to fibroblast growth factors [1]. The repeat is also found in MG160 and E-selectin ligand (ESL-1).	20.60	20.60	20.60	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.16	0.72	-4.04	85	1785	2009-01-15 18:05:59	2003-04-07 12:59:11	12	15	137	0	1097	1610	20	58.80	24	71.91	CHANGED	pcCc.ptlhph..pp..spDh+.....lsstLhpsCcp-l...pc..aC........sp............ttspupllpCLppphpp.tp	...........................cCc.ptlhph...pt....spD.h+..............lsstLhpuCc....s-l...pc.....hC...........ss..................................ttspGpllpCLhpphtp..t......................	0	339	467	794
+1696	PF00031	Cystatin	cystatin; 	Cystatin domain	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	Very diverse family.  Attempts to define separate sub-families failed.  Typically, either the N-terminal or C-terminal end is very divergent.  But splitting into two domains would make very short families. All members except Swiss:Q03196 and Swiss:Q10993 are found. Pfam:PF00666 are related to this family but have not been included.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.92	0.72	-3.86	43	2054	2012-10-01 19:28:07	2003-04-07 12:59:11	16	20	367	81	813	2132	5	88.60	17	54.95	CHANGED	Gulpssss..sssclpcslchAlscaNpps..tsthhchhclhcsppQVVuGh..pYhlchplscssC........ptpshpsCshh....ppphthsshpshptst	.....................................................hps...sssplpph...sphul..p.p....hN.........p.....ps........................s........h..........h....hp.h.h.c...l...h...c......u......p...p.....Q..l..V......u...Gh......pYh..lp..lclt.cs.p.s............ptp.hp....s.p.h...............pth..................................................	0	158	262	454
+1697	PF01578	Cytochrom_C_asm	CytC_asm; 	Cytochrome C assembly protein	Bashton M, Bateman A	anon	Pfam-B_114 (release 4.1) Pfam-B_8014 (Release 8.0)	Family	This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium[3],  CcmC from E. coli and Paracoccus denitrificans [2,1] and orf240 from wheat mitochondria [4].  The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an  ABC (ATP binding cassette) transporter complex. It is also proposed  that this transporter is necessary for transport of some component  needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif [3], orf240 also contains a putative heme-binding motif and is a proposed  ABC transporter with c-type heme as its proposed substrate [4]. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither [1].	21.10	21.10	21.10	21.20	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.60	0.70	-4.79	39	8917	2012-10-03 10:28:09	2003-04-07 12:59:11	15	16	4477	0	1718	6398	4666	196.50	21	51.54	CHANGED	huslhtulhhhshshshhhhlh.t...p....thhuslshsssh...........................lhhuhhhh.......................l.....tssslssslps.hLhhHlshhhhoYushhlushhulhhL...........................................................................ht.htthcphshphhhlGashLTlullsGuhWA..p.sWGsaWsWDP+pshuLlsWllasuhL+sth..pc.shtuctsulluhlGFhllhlshauVphh..slc	............................................................................................................................t..sh.h.h.hs.h.h.h..shh.....hhh......................................p.........t..........................th...........h.s.t..h.h....h.h...sh........................................................................................................................h.s.h.uhhhh.................................................................hh.............h..t..s..t.s.l..s.s..h..L.p....s......h..l.h.hHl..sh..hh..hu.Y...s...s...hh...ls.h.h.h.ulhhL..........................................................................................................................................................................................................t...h..........h..tt..ht...p..h..sh.t.h...s...hG...hh.h..ho...l.u.l.lhG.u...h..Wu........p.sW....G...s..a..W.h..W..D.s+.ts.hu..hl....s.ah..las.u..h..la.hhh........pp...sh..t..t..p..h..s...s....h..h..s..l..h.u.h.h.h.hh.l.shahVp.........................................................................................................................	0	525	1095	1442
+1698	PF02224	Cytidylate_kin		Cytidylate kinase	Bateman A	anon	Pfam-B_1582 (release 5.2)	Family	Cytidylate kinase EC:2.7.4.14 catalyses the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.	20.40	20.40	20.40	20.40	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.69	0.71	-4.79	14	4159	2012-10-05 12:31:08	2003-04-07 12:59:11	13	26	4102	23	894	2951	2326	155.70	40	63.80	CHANGED	hphhhphplphh.p.st....shhsGpDlosp.IpopEVuptsStlushPtVRshhschQ+phuc..ssslVhEGRDlGTVVhPcAplKIFLsASsEhRApRRhpphstpu..s.sh-pLlt-ltcRDphDppRssuPLhhAtDAlhlDTSsLolp-Vl-cllp	........................................hs....phplph.....p..t..s..t..p....Vhl....s.G..c..DV.op.t..IRsp-VustsS.tVA.u.hPtVRctLlptQRp....h.....u............p..........t.........s..........G..........l.....V.hDGRDIGTVVh.P-.........A...p....lK....IFLsASsEpRAcRRhpph..t........p.....+.........G......h......s...s.........s...h.........-....p..l...hp-.......I.pcRD..pp.D..p.sR.....p.....lu.....P.L.....c........As.....D......A......l.....h.lDoTsl....oI-pVlpplh.t....................................................	0	314	596	761
+1699	PF01265	Cyto_heme_lyase		Cytochrome c/c1 heme lyase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.40	20.40	22.40	21.30	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.16	0.70	-4.80	46	463	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	263	0	351	449	4	246.90	36	87.58	CHANGED	M.................s..t...............................s...spCPlscpspp......................................................stCPspt...............................................tphss..sshhss.spp.ssspshsLsscREhSSIPRs........................................t.usus........WlYPStpQFaNAMlRKGa..t.pp.....tsshcslVslHNtlNEpAWpcIlcWE..tha..................................scpCs.sP+LhpFtGcsc-...hoP+Aphpph.hG........hphPFDRHDWhVsRC.G..........+-VcYVIDaYs...Gssps..........p.....s......haLDVRPA.Lsohpu...sh-Rhh+h	.......................................................................s.....................................................tCPhptt......................................................................stC.Phtt..............................................p.p.l..sP......ssh.s.s.sp..p....s.ssQs..hs.LsscRphSoIP+u.........................................................s..ssss.......W.YPS.Q.Fa..NAMlRKGa.t.t...tphs....tcshcslltlHNtlNEpAWpEIlcWE..t..ha...........................................................sppss..sP+LhpFtG+sp-...hSP+ARhpph..hG.....................................hphPFDRHDWhVsRC..G...............................ccV.RYVIDaYsGssst.........................p.....s.......shhLDVRPA.lsohpush-Rhhh.h....................................	1	120	196	293
+1700	PF02322	Cyto_ox_2		Cytochrome oxidase subunit II	Bashton M, Bateman A	anon	Pfam-B_997 (release 5.2)	Family	This Family consists of cytochrome bd type terminal oxidases that catalyses Quinol dependent, Na+ independent oxygen uptake [2].  Members of this family are integral membrane proteins andi  contain a protohaem IX centre B558. One member of the family  Swiss:O05192 is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella  pneumoniae [1].	28.10	28.10	28.70	28.50	27.50	28.00	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.19	0.70	-5.27	134	4601	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	3012	0	866	2836	242	331.80	32	94.78	CHANGED	sLtllWahllulhlhhYslhDGFDhGlGhLh.sh....hsc...........-p-RchhlNolGPhWDGNEsWLlhuGGulFAAFPhsYAslhouhYlslhlhLhuLIhRuVuFEaRtK.st.s.ph+.....phWDhshhhGShlsshhhGlslGs.llpG...lshs.............................................ttas....Gs..............h.hsh...lsP.........FullsGlsslshhshhGusaLhhKTcG....p.lpp+Apphuthhshsh.hshhhhss.............................hhshh.tsthhtpah.shshhhhh.sslsllsslhshhhh...thp+............pth..uFhsoulsh.hhshhslshuhaP....hllPus...........sLTlasAuuuthoLphhhhsshlhlPllLsYssasYhlF+	......................LphlWalllulllhsahlhDGFDhGlGhLh....h.....lu+..........................s-p..E...R...+...l...hl..N.....ol.....uPhWD.....GNpVWLlhuGGAlFAAFPhsYAs.hFSuhYlshhl.lLhuLhh.RsVuF-aRsK..h...ssc.a+.....phWDhuhh.lGShl.ss....hlhGl...AhGs.llpG....lshs............................h.....................thtasGs......................h.hpL..........LsP...............Fu.l..l.sGls...s...lshh...hhhG....usa..Lt..hKT..pG.....t.lp.pR..u....pphuphhullh....hlh.h.h.lsu.....................................hhssh.....sss.h.hp.p.a.........h..p.h.P......h.h.h.hh...ss.l..ul.ls..hlhs.hhhh....thp+.....................ssh......uFlhsslth.hhshhshuluhaP....hlhPus................sLTlas......AsSot.hTLplMhhss.ll.h.l.PllLsYshWsYahh...........................................	0	238	510	701
+1701	PF00283	Cytochrom_B559	cytochr_b559; 	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits	Finn RD	anon	Prosite	Family	\N	29.50	29.50	30.70	30.30	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-6.92	0.72	-4.66	8	2001	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	993	42	112	639	147	28.50	55	47.05	CHANGED	sscshoYPIFTVRWLAIHulAIPolFFlG	..........hphshs..IholRahslHulslPolFhhG...	0	28	71	99
+1702	PF00284	Cytochrom_B559a	cytochr_b559a; 	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit	Finn RD	anon	Prosite	Family	This family is the lumenal portion of cytochrome b559 alpha chain, matches to this family should be accompanied by a match to the Pfam:PF00283 family also. The Prosite pattern pattern matches the transmembrane region of the cytochrome b559 alpha and beta subunits.	25.00	25.00	28.20	27.70	22.80	22.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.93	0.72	-4.44	25	1065	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	972	19	62	465	127	39.70	82	49.73	CHANGED	LAYDVFGTPRPNEYFTpsRQclPlloDRFsAhpQl-phsc	...........LAYDVFGSPRPNEYF.TESRQGIPLITGRFDuLEQLDEFS.p...	0	14	39	56
+1703	PF02335	Cytochrom_C552	cytochr_c552; 	Cytochrome c552	Mian N, Bateman A	anon	Pfam-B_19175 (release 5.2)	Family	Cytochrome c552 (cytochrome c nitrite reductase) is a crucial enzyme  in the nitrogen cycle catalysing the reduction of nitrite to ammonia. The crystal structure of cytochrome c552 reveals it to be a dimer, with with 10 close-packed type c haem groups.	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.24	0.70	-12.83	0.70	-5.79	38	1136	2012-10-01 23:37:15	2003-04-07 12:59:11	10	12	966	82	171	735	44	413.10	48	88.71	CHANGED	s.tpau........+taPpQYcoW+cTsE..ss.........s................htDtLcccPtLslLWuGYuFu+DYscPRGHhYslpD.hpohRssss...........stsuuChoCKoPssPcLhcchG-........sYFsspascstscIs.......ps.............luCsDCH-sp.shp.......L+loRP.tlt+AlcslGh.......................c.hc...to+p-hRohVCAQCHVEYYFptc.............................................sptVpFPWspGh......olEsh.pYYDphs..........FtDWTHulSts.MLKAQHP-aEhas.pGlHupsGVoCsDCHMPhsp.tsupKhoDH+.lt.SPL.sshp...coCtsCHp.poc-tL+spVtshps+shphth+AtptlspAth-h................ctAh.cAGAspcchc.....puhphhR+AQWRhDashAppusuFHAPpEulRlLusul-cAscAcspLtplLAptGlps........PshsshphAphshshshc+h.hct..pp.lcs..hsp................................t+	.........................................................ts..Epau.paPcQYtSWpsTu-..ps...........................................thctLt..ccPpLlILWAG.YsFS+DYNcPRGHhaAlsDlccTLRTGu.Phss.pcG...................................s.P.hACWoCKSPDVs.RL....I.pc.G-................................cuY.ap..u.KWuchG..sE.Is........Ns.......................................lGCADCHsss.o..c.......LploRP.hshcAhculG+............................s..hc....cAs..R.-.pohVCuQCHVEYYFcuc...........................................................sKsV.pF.PWD..cGh.......................cVEshE...p.YYDclu..................FuDWTp.....sLSKsPML.KAQHP..EYEh.W...o....sG.......l..H..G..c....N....s...VoClDCHMPpVp....tpG.K....hY......TDH.+..Is......sP..h....cs...hs......pTC..t..sCH......s....Q..s..c.st...Lp..p.hVt-+ppplp-hph+s...EcpLV+AHhEA..................................................+tAh.....D.A.G.....A.T.....-.tEMK......slhptIR+AQWRWDhuhASHGht.....hHAPcEuhRhLusAhDcAtcARsKLscl..LApp.Glsc....tl.h..P...D.I.STtpKApthlGl.sh.pp.hpAtK..ppFlcsl.lPp.W.cpAp..ss..............................................	0	57	111	146
+1704	PF03188	Cytochrom_B561	Cytochrome_B561; 	Eukaryotic cytochrome b561	Mifsud W	anon	Pfam-B_2927 (release 6.5) & Pfam-B_7165 (Release 8.0)	Family	Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.96	0.71	-4.34	48	1285	2012-10-03 10:28:09	2003-04-07 12:59:11	11	38	290	0	837	1341	24	131.30	21	41.09	CHANGED	hHPllMslGalhLhG..........EAlLsa+.s...hh.hs+pspKhlHhsLphlAhhhullGlhuhap.+stp..........t...h.sphhSLHSWlGlsslhLaslQhlsGhssahh....PthstthRshhhPh..HshhGlssalLulsoshhGh.pphhFt	...................................................Hshhhhhuh.h.hhh..s...............................u.l.lh...h+.....h......................h..................s....c.........h....hh......h.......lH..hhlp.h..l.uh..l..l.ul..s..G..hsh.s.h...t.h.c.s.t.............t.....h...sp..h.h..........o....h......HuhlGlssh.h.L.h.h.l....Qhl......h.............G.hh...h..h....hh.................P...t...h...s...t...p.......h.....R...t..h..h..h..h..........HhhhGh..shhl.luls.shhhGh.......t...............................................	0	230	447	659
+1705	PF00032	Cytochrom_B_C	cytochrome_b_C; 	Cytochrome b(C-terminal)/b6/petD	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	18.90	20.70	19.30	20.60	18.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.54	0.72	-3.79	114	70433	2009-09-12 14:19:01	2003-04-07 12:59:11	12	20	28713	95	599	68332	2102	89.80	73	27.89	CHANGED	.ANPhhTPsHItPEWYFL.hYAILRS..................IP.....sKLsGVluhhhSlllLhhlPh....hp....puphpohp.ap.shh.phhaah.....FlssallLsalGupPs-......Pah..h.luplhol.h...YF	........................PANPL.s.TP.PHI.KPEWYFLFAYAILRS...............................................IP...............NK...L...G.G.VLAL....l....hS.I...L...l.Lh.llPh...LH.............T.S.K...Q.R.....u.h.....t.....F...R....Plo.....QhL.....FWh.....Ll.Ash.hlLT.WlGu..PV.Ep...........Pa.l.hIGQlASh.h...YF............................................	0	158	359	481
+1706	PF00033	Cytochrom_B_N	cytochrome_b_N; 	Cytochrome b(N-terminal)/b6/petB	Sonnhammer ELL	anon	Prosite	Domain	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.39	0.71	-4.94	92	8451	2012-10-03 10:28:09	2003-04-07 12:59:11	14	32	3033	2	1429	91159	3309	164.10	19	83.40	CHANGED	httashhh+...........lh.HW..hhulhhlhhh.h...sGhhhh................................................................hhh..hshtthhhtlHhhhGhhhhhlhlh+lhhthhp........................................h.t.t.ssttttshhtphshhhlhhh.hhhhsloGhhh....................................h..hh..stshhphh.....thlH.thhshllh.shlhlHlhhshhtphh....shlptMhsG	.................................................hash..phhHW......lhul.shl.h.hh...h......oGhhhh....................................................................ths.t...h.s.h..h.h..h...h.p.......l..HhssG.hh....h....h...l.s..hh..h+l.hhthht..................................................................................................................................................h..h......h.p.h.ht..p...h.h.a.h.h.hhhh..hhhh...l.o.Ghhh................................................h...........h...h..................h..h.....thh.............t.h.H...h.h.s.h..h.hh.hhl.hhHhh..h.Al.hhph.........sslttMh..........................................................................................	0	342	765	1112
+1707	PF00034	Cytochrom_C	cytochrome_c; 	Cytochrome c	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	The Pfam entry does not include all Prosite members.  The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, Pfam:PF06181, has now been merged into this family.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.47	0.72	-3.15	237	12531	2012-10-03 10:02:11	2003-04-07 12:59:11	16	182	3088	283	4329	18590	7463	94.00	18	36.97	CHANGED	hspG...pplh.p.t.......pCssCH.utssps...........................................Pslsshstthhhpthtthhttt..h...........thh.tth...shh....................................loc.p-htslssal.php	.........................................pG.ttlh..t..t...............sCsu.CH...us...s.s..t.u.st.h................................................................................hPsL..t...s..h...s.....s....p.....h......h...h.....t.....t......h......t..t.........h...h..s...s...s.....t..t.......h..........................................thh.....t..t.....h..............................................................................loc.p-..hpsls....uYlts..t........................................................................................................	0	1149	2550	3504
+1708	PF02167	Cytochrom_C1	Cytochrome_C1; 	Cytochrome C1 family	Mian N, Bateman A	anon	IPR002326	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.64	0.70	-4.69	124	1691	2012-10-03 10:02:11	2003-04-07 12:59:11	10	8	1421	83	579	1376	2156	190.90	30	70.78	CHANGED	a.....sasG.hspaDpsuLQRGhpVYppVCuuCHShphltaRpLsc.............luho.......-sp..........l+shAtp...p.h.s....sGp........Rsup.uDhhssshsscpAtthhssGAhPPDLSLlu+ARt....................sGs-YlaoLLpGY........hc.s........................Ps......................tsstahNshF.......................................su..luMs.sL.h-t....l.....................................................pasD.Go.........ssoh-QhucDVssFLhWsAEPphppRKphGhhVllFL.slhsslhYhhp+ph...Wpsl	...........................................shhDps.ulpRGhplahph.C.uCHSh.phhtapplhs.............lshs..tpp..................................h+t.hh................................pup...........phuDhh.sshssp..pAsphh..GAhPPDLSlls+uR..........................GsDalashL..pua.........p.s......................................ss................t.hh..h.N.hF.......................................ss.....luMstsL...p.....s..........................................................phts..Gs.............stphsph..scD.lssFLtasuEP...tt.tpR.+phGhhlhhaL..s.l.hhh..ls..hhh..K+phWpp...........................................	2	173	330	465
+1709	PF01322	Cytochrom_C_2	Cytochrome_C_2; 	Cytochrome C'	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.82	0.71	-3.57	95	629	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	492	53	234	648	813	114.10	23	73.21	CHANGED	pc...s.lchRQuhh.ph.hutshu.sluuM.s+GchsaDsststtsAsslssluphshst..F.stGocsus.....TcApPpIW.pchscFppphsphppsuspLsssA.tsG..Dh.sul+sAhsslGts.CKuCH-saR	............................................................................t...lp.Rpshhp..ht.ph.t.thssh.hc.G..p..sa-stt..htttut..tls..th.u.ph........ph..F...tsspts...........scAhstlW..p..c..hscFpt.ttpphpsssspLss.uA....psu...ch...s....slpsuhsp.huts.CcuCHcsaR...............	0	54	144	186
+1710	PF02085	Cytochrom_CIII	Cytochrome_CIII; 	Class III cytochrome C family	Mian N, Bateman A	anon	IPR002322	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.92	0.72	-11.89	0.72	-3.92	24	410	2012-10-01 23:37:15	2003-04-07 12:59:11	11	26	147	90	206	698	264	94.70	21	46.57	CHANGED	P.....hshcsPssst.........pptsVsFsHpsHt.ps.....sCpsCHHt........tsttphssCss..CHss.t........scps.tsh...hpAhHspps..........oClGCHpphttpt.t.............ps.suC.stCH	................................hht........................tsl.FsH..t..hHs.ph..t..........sCpsCH..+s.......................sstssh.....t..s.....Css........CHsth...........................tptt..h.th.........ht..u..h..Ht..............................pCh.s.CHtp.t................................C....CH................................	0	92	172	198
+1711	PF03264	Cytochrom_NNT	Cytochrome_NNT; 	NapC/NirT cytochrome c family, N-terminal region	Mifsud W	anon	Pfam-B_1404 (release 6.5)	Family	Within the NapC/NirT family of cytochrome c proteins, some members, such as NapC Swiss:P33932 and NirT Swiss:P24038, bind four haem groups, while others, such as TorC Swiss:P33226, bind five haems. This family aligns the common N-terminal region that contains four haem-binding C-X(2)-CH motifs.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.29	0.71	-12.03	0.71	-4.83	111	2644	2012-10-01 23:37:15	2003-04-07 12:59:11	9	24	1304	8	392	1397	89	166.30	41	59.71	CHANGED	ps...stphslshll...llGhlsGllhauuhpsshchTsopcFC.lSCHp.Mpss.apEappolHapNpsG.VRAs.CsDCHVP+..chh.sKhhpKhp.Au+-latch.hGplsT.EKF-.t+RhphApctWtch+sssStpCRsCHshp.tMch..spQ....ptpApptHpps..................h....tpsp..TCIDCHKG.....I.AH.....phP.ch	................................h...+htlhsll..llG..h.l..sG..l..h..h..h.ssh..p....su.hc.h.T.....sopc.FC.lS.CH...p..Mps.....s.....YpEY.p.......p.......o.l.....Ha......p...........N.t.......pG....lRAp...CsDCH..l.........P..+............-hs...shhh.pKlp....ASK-lYtph..hs.pIDT........P-K..FE......s.+Rhp.....hAcp.pW....p.chK....sN.sS...t...pCR..s..CHsa-....tMDh...spQ............pspA....s.+..........aptA.......................................h...........ccsp.....oCID..CH.KG..IAHpLP-.........................................	0	120	230	327
+1712	PF01801	Cytomega_gL	Cytomegalo_gL; 	Cytomegalovirus glycoprotein L 	Bashton M, Bateman A	anon	Pfam-B_1420 (release 4.2)	Family	Glycoprotein L from cytomegalovirus serves a chaperone for the correct folding and surface expression of glycoprotein H  (gH) [2]. Glycoprotein L is a member of the heterotrimeric gCIII complex of  glycoprotein which also includes gH and gO and has an essential  role in viral fusion [1].	25.00	25.00	144.60	144.50	20.70	19.80	hmmbuild  --amino -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.38	0.70	-4.85	7	80	2009-09-12 02:32:10	2003-04-07 12:59:11	11	1	37	0	0	58	0	204.20	59	82.04	CHANGED	hpscChcshhpChpu......p..ShhpPlhs....cusl......hSpLIRapp...........ptphhss..lhls--FL-plhLLaNNssQLRsLLTLl+.S-sussWhsahpGYspC.tsssslaTCV--lCppYsLp+LpYspslFsEsVlGFElssP........shulLlhlcNptT+ss+lVRlssso......loLFDulYNhl+pFhhch.ulshsLlpcLcpYpspLPs.a+puc..slhtRsh	.ss.sECsELTRRCLhGEla.pusch-SWL+PLVN.VTsR....DGPL.......SQLIRYRPl..........TsE.AAso..VLLDDuFLDTLALLYNNPDQLRALLTLLu.SDTAPRWMTlMRGYSECGDGSPAVYTCVDDLCRGYDLTRLoYspslFTEpVLGh-lsPP........hhsVlVhlRNptT+sp+sVRlPs..oo......loLF.ulYNhl+phhh+h.pLDssLlppLcpYhstlPs.h+poc..pl.tpp.h........	0	0	0	0
+1713	PF02239	Cytochrom_D1	D1_heme; 	Cytochrome D1 heme domain	Bateman A, Mian N	anon	Pfam-B_3322 (release 5.2)	Domain	Cytochrome cd1 (nitrite reductase) catalyses the conversion of  nitrite to nitric oxide in the nitrogen cycle. This family represents the d1 heme binding domain of cytochrome cd1, in which His/Tyr side  chains ligate the d1 heme iron of the active site in the oxidised  state [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	369	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.20	0.70	-6.16	8	7650	2012-10-05 17:30:42	2003-04-07 12:59:11	11	55	672	42	338	8166	222	221.80	52	91.82	CHANGED	phshtNLFsVs.RssGplsllDGDspc.luhl-otYAl.HhShh.us.GRYlYVhGRDGtlohlDLaspc..hVAEV+hGhsuRulslS.....-s+allsGsYhPsphslhDucTLE.lpllsTpGhssss....spsRVuAllsu.h+spFVVslK-TGclhllsYosh.cslpTppIsuA+aLaDuuassstRYalsuh.ups...KlslhcsccGthssLlDs.G+ss+sh.sushsH.phG.hWssuphtshshshIGpcshs....hhctpsWKhlppIsstGsG.lFl+THPcSpalWVDshhsP-...scuVtVhDpcsL.........lshsltshsGhs.......VlpsEFs+cGDpVWlSVWsucs...ALVVaDs+TLcLh+sls...hhoPoGKFNVaNs	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AuIlu..S....pP-.alV.Nl.K...E..T.G.pI.L.L..V...s........YpD............l.....c......N....................L....p....................s......T...............s..I............s....A..A...+......F.L..H.......D..G...Ga.....D....u....o.....+....R.....Y...F...Ls.A.....A.....N.t.Ss..............K.lA..VVD..o.K.....-..p.......K...L..s.......A.....L....l....Ds...sc..h.P.H..P.G.....R...G.AN.a.s....cPc.a.......GP.V..W.....sT..u.....t.........L..G..s-..s....l.o...h...IG...T....D..Ptp..........H..p.p...A...WKVVp..slc..G..p...GG..G..SLFl.KT.HPp.Sp....pla..s..Ds.s..hs.P-.......thup.o.l.s.Vach..tsh......................h.h.....l...t......st.......................................................hhp...cas.tG.p....hhh....................................................................................................................................................................................................................................	0	91	229	292
+1714	PF02109	DAD		DAD family	Bateman A	anon	Bateman A	Family	Members of this family are thought to be integral membrane proteins.  Some members of this family have been shown to cause apoptosis if mutated [1], these proteins are known as DAD for defender against death.  The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation [2].	20.20	20.20	20.30	21.10	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.48	0.71	-4.02	30	370	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	306	0	230	340	0	104.90	45	83.17	CHANGED	sus....h.s.llsphhppYhspTP..p+LKllDAalhalllsGllQFhYCsLl.GsFPFNSFLSGFIosVGpFVLslsLRlQlN.......tNcspF.hulSs.ERAFADFlhAsllLHhlslNFIG	....................ss...h.sllpphhppYhssTP..p+LKllDsalhalllsGhlQ...FlYshLl.GsFPFNuFLSGFlSsVGpFVLslsLRlQlN......................pNttpF..tslSP.ERAFADFlhusllLHhllhNFls.......................................	3	77	127	189
+1715	PF00130	C1_1	DAG_PE-bind; C1;	Phorbol esters/diacylglycerol binding domain (C1 domain)	Bateman A	anon	Prosite	Domain	This domain is also known as the Protein kinase C conserved region 1 (C1) domain.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.82	0.72	-4.23	46	6123	2012-10-02 13:15:50	2003-04-07 12:59:11	17	344	330	24	3317	5447	1	52.60	31	8.26	CHANGED	HpFttp......sa.tpssaCstCsphl...........h.htppGhpCp....hCphpsHc+..CtptVsstCsss	...................HpFhhp............sa..pp..Ps....hCshCpphl.........................hG..hhp.QGh.pCp..................tCp.h.s...sHc+..........Ctp.plsspC...t..................	0	793	1126	2107
+1716	PF03982	DAGAT		Diacylglycerol acyltransferase 	Finn RD, Wood V	anon	Pfam-B_11378 (release 7.2)	Family	The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT) [1,2].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.82	0.70	-5.72	6	1100	2012-10-02 00:16:30	2003-04-07 12:59:11	8	11	361	0	723	1216	48	230.60	28	64.76	CHANGED	ahLFhTspWhllsLYulWhhYDhsoP++GuYpssWsRphtla+aFAsYFPlpL.hKTu-.Lsss+NYlhGYHPHGIlulGAassFuTsuTGlhcpFPGIR.plsTLs..GpFhhPaRREhhlhhGhI-sSRESI-alLs+stp.G+AlVlVlGGApEAL-AHPGpcsLTLtsRKGFV+hALcpGApLVPsYuFGENDlYcQh-NPcGSpLRphQchhK+hhGhoPPlFaGRGlFs.hshGLLPaRKPlsTVVGtPIpVsKs.cPTpEpIDclHuhYh-tLt-LFEEHKsKaGls.sspLllp	..............................................................................................................................h.............................................................................................h......p...................h.hph..h.h.t..Y..F..s.h.pl....h....p......s.....t....h.........s.p..p....p..........Ylh.uh.aPH.Gl.hs..h..u.h.....hhshs.......p.......................t....................h............t..............h....hs.t.h.t..........l.....h..sls.....F...h.....h.P.h...h.R-hh.h......h.....G.hs.ss.scpshth...h...L...........s..........p...........t...........t...........t...............lhll.sGGst..E.u.L.....p.s......p..s....s..p............p..l....hL.p.p.R.+GFl+l.AlppG........s......s.......LVPshsFG..E.......s.......-.......l.......ap...h................t........h....h..............h...t.......h.h....t....p.h........h.t.....h...s.....s..h.h.......h..u.....h........h.........................h............P.h..p...............t.s....l..h........V...l..G..p....Pl..............l..............p................p.P...s........p.......lpt.h.+.t.....ah.t.tL.plapph+..h.s...............h..................................................................................................	0	239	386	554
+1717	PF01219	DAGK_prokar		Prokaryotic diacylglycerol kinase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.90	21.90	22.40	25.20	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.08	0.72	-4.44	186	3222	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	3038	3	605	1802	403	102.60	36	78.24	CHANGED	htYuhpGl.ttshppEtuFR.clhhullllsluhhl......slothEhhlllhslhlVLhsEllNoAlEslVDhlu..-aH.LuttAKDhuuuAVhluhlhusllhhhllh	.............h.tauhpGl.tsAhp.pEtsFRpchhhsllslshu.hh.l......slstlEhllLlhulhLVlhlEllNoAIEslVD.hlu....s-aH..Lu+pAKDhuuuAVLlshlhA..s..lshhllhh.......................................	0	181	367	508
+1718	PF00609	DAGK_acc	DAGKa; 	Diacylglycerol kinase accessory domain	Ponting C, Schultz J, Bork P	anon	SMART	Family	Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.	21.30	21.30	21.40	21.90	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.18	0.71	-4.09	42	1202	2009-01-15 18:05:59	2003-04-07 12:59:11	14	102	195	0	702	1147	5	153.50	36	20.57	CHANGED	sMsNYFSIGhDAcluhsFHptRppp..PthapuphtNKh.hYst.hGspc.hh.ppshtsh..cplplc..................s-sppl....plP..ssculllLNIsSauuG.sshWssspppt...................at.tshsDGhLEllulpushclutlpssltps.hRluQu.spl+lphpp............phshQlDGEP	..................................................................................................hNNYFulGh................DAp..luhcFHptR...E.cp......PpK.....Fs...S..Rh.pNK..............h......hYst.hGspc......hh..ttot.+s...L..ppplp..lp................................................................sDGptl....pls...slpu...Is.hLNIPS..asGG.sshW..Gsspcpp...................................................ats.phsD.thLEVVGlp..ss.....hphu.t..lp.......s...s.h......t....ps...hRl....AQs.pplplphpp................slPhQ..lDGEP.....................................................	0	211	323	501
+1719	PF00781	DAGK_cat	DAGKc; 	Diacylglycerol kinase catalytic domain	SMART, Coggill PC	anon	Alignment kindly provided by SMART	Family	Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family [5].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.93	0.71	-4.71	125	7254	2012-10-02 15:20:27	2003-04-07 12:59:11	19	132	3378	25	2390	5666	830	128.70	23	30.86	CHANGED	phhlllNPpu..Gpppsp.......plhtt.h..ppt..h..p......h..pl.hps..p..p..tsss..pt......hth.hts.hsph...............tllss.GGDGTlspVlsul...........h...p......p...sh...................s...lullPsGTuNshA+slth.stshtt............................................tthhthht.pht..sp...ssthsph	............................................................................................hhllhN.P..p.S..Gp.ppst......h.......tplht.h..h...ppt...t....hp....................h...pl...hho.......pp.......tssu...pp....................hst...hts..hssh...................................shllss.GGD....GT....lsc......V.lsul.................................................h...p......p.sh.................................s..lull...P..h..G.T.u.N.DhA+.sL.s.l..s.ts.tt............................................th..hhht.th....hsh......t..........................................................................	0	772	1353	1927
+1720	PF00793	DAHP_synth_1	DAHP_synthetase;	DAHP synthetase I family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1032 (release 2.1)	Domain	Members of this family catalyse the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.	19.80	19.80	20.50	20.10	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.66	0.70	-5.71	28	8958	2012-10-03 05:58:16	2003-04-07 12:59:11	15	18	4112	276	1994	5818	4302	285.30	28	87.41	CHANGED	chsls.t.............slhhGpspphlllsGPCSlEs.-tsh-hAp+Lpplus+ht..lhllh+uah-KP.Rooshua+Ghh.-stLphhtclpcsh..............GlslsTEhlDstssphlA-hsslhpIGARsscspshlctAuthspPVslK+Gps....sulpthtsAuchhhhhGs..........ssslhhC-RGlRsGc.tsNppshDlpulshhpcts.hh.......PlhlDsSHusup+s...........hh.p.hVsshspuulAsG...hsGlMlEsH.sPupAhsD.......usptLsht...shtphhh-hsphlhp	...............................................................................................tthhpht...................plhhGp...D...p..chlllsGPCSlc..s.-tsh-hAc+.Lt.s.l...s..p..c..h..t....l.lVh+saa-KP..posh.ua+GL....ht......-......st.......l..c.hhhclpcsh.................................GlP.s.s.T.Ehh-s.ss....p.h.l.u.D.l.l........s........hhtIGARs.scs....pshh....c....hA.....u......t....h.......u..t......P....VshKpGps..............luhsshtsAs..p...h..th.h.G........................spss...hschhl...R...s......G......p..t......sN....h.t.s.hD..l..tsss.....h.h.hpts....tl................sl.llD...soHusup+s...........htp..p....hVs.p.............s......p..s......t...lusG.................lsGlMlEo..H.s..s...uptp.s.-........us..p..tlsh...u.p.hs.hshhhp.sp.h.t....................................................	0	632	1204	1652
+1721	PF01474	DAHP_synth_2		Class-II DAHP synthetase family	Bateman A	anon	Prodom_1974 (release 99.1)	Family	Members of this family are aldolase enzymes that catalyse the first step of the shikimate pathway.	19.40	19.40	22.40	19.50	17.40	19.20	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.44	0.70	-6.12	111	1570	2012-10-03 05:58:16	2003-04-07 12:59:11	11	4	1229	18	510	1307	2300	383.10	49	93.61	CHANGED	pWsssS...WRspPhtQpP.sYPDtstLpplpppLpphPPLV.FAuEscpL+ppLApVApGcAFLLQGGDCAEoFs-hsuspIRcph+llLQMAlVLTauuuhPVVKVGRhAGQaAKPRSushEsh.....-G....lsLPSYRGDhlNuh-FotpuRhPDPpRhlpAYppSAuTLNLlRAaspGGhAc.Lc.plcp.......WshsFl.tpushup+Yppl..........AscIscuLpFMp....AsGhs.t......pl..............................ppschaTSHEALLLsYEpALTR......................h.............D..opo.Gp.........................a..YssSAHhLWIG-RTRQlDuAHVEFhRGlpNPIGlKlGPohss--llcLl-tLNPc....sEsGRLTLIsRhGAc+lpctLPtLlcsVcppG+p..VlWsCDPMHGNThpus..sGaKTRpF-cIlsEVpsFFclHcup....GoasGGlHlEhTGp......sVTEClGG.upsls-.pDLssRYcTtCDPRLNupQuLELAFLlA	..........................................puWcsh.s.h.hQtP.pYsDt..t..tltpV.tpLpphPPLVh.AuEscp....LcppLApVupGcAFLLQGGDCAEoFsphss....spI+s.ph....+...llLQMA...lVLTauuph.PVVK.lGRh...AGQaAKPRSsshEth..........s.GlpLPSYRGDhlN.Ghphstpu.RhPDPpRhlpAYtpSuuTLNLlRAhspGGhAsLc..plcp........Ws..hsFl..tp..o.......t.t+Yptl..........ApcIscuLt.FMp....AsGls..........t.tL.........................................pps-haT.S....HEA....LLLsYEpAhTR.................................................................h.................D.....sts...sp.................................h..YssSuHhlWIG-.R....TRQlDsAHV-FhpsltNPlGlKlGPshss--llpLh-h.L..sPp.............s.-sGRLTlIsRMGuc+ltstLPtllcsVptp.G..p..p..VlW.sDPMHGNThpus..........sG.aKTRtF-pl..hsEVpuFFclHpu.....GoasGGlHlEhTGc......sVTEChGG......u......pslop....psLssRYcTtCDPRLNspQuLELAFllA.....................	0	158	324	433
+1722	PF02733	Dak1		Dak1 domain	LOAD	anon	LOAD	Family	This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29. 	25.00	25.00	26.10	25.40	23.90	23.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.91	0.70	-5.87	9	2939	2012-10-02 12:41:15	2003-04-07 12:59:11	12	12	2046	34	705	2165	413	309.40	40	77.08	CHANGED	LtGLspuNPs.Lsllpcs+Vlhpsss.....s.sKVullSGGGSGHEPsHAGFVG.cGhLsuAssGpIFASPSoKQIaoul+AV.puspGsLlIVKNYTGDILHFGLAAE+A+AtGhpsEllsVuDDVSVG+p+suhVGRRGLAGTlLVHKIsGAAAtpG...LsLcpVsplAcplssNhsTIGuSLsHCTlPGpchpsp............LscsEhElGMGIHNEPGht+tuPlPolD-LVuc.hLchLLspssc-Rsa.................VphsssD-VVLLlNNLGGsS.hELhsltppls-pL.pcasIpPsRshsGsasTSLsGsGFSITLlpsocsstchhcthscssshsssh	...............................tGhshu.asp...l..p.h.h....t..s..s..p...l.l.h.+tch.......tpsKVullSGG....GSGHEPsHuGaVG.cGMLsAAssGplFoSPos-plh.p.A.h.....+.................s.s.......c.......s...............G..t...........G...V.LhllK........NYoGDlhNFchA.....s.Eh..A.c.t.......-....G..............l....c.VcpVll..sDDlAlp..s..s..h...............hs...ssRRGVAGTlhl......aKlsGAA.A-pG........tsL-p.lt.p...luc........+ls..s.....p.....s+..olGlALssCTlPusG.+ss..F.p...........L.s...-.sE..hEhGlGIHGEPGhc+pph..ps...ucp.lspp.hhs.......pllpp.....hs........................................h..t..t..u.......c.cVhlLVNGlGuTPl..ELallhscl.t.ph.L..p.p..pGlp.lt+sh.l.G..s..ahTSLDMsGhSlTLl..c.l..D.-..-.h.h.t.hh.ps.st.......t.......................	0	221	420	588
+1723	PF02734	Dak2		DAK2 domain	LOAD	anon	LOAD	Family	This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.	23.70	23.70	23.80	23.70	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.98	0.71	-4.60	175	4573	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	2828	8	1004	3192	390	167.00	29	41.01	CHANGED	slGDGDpGtsMspGhpushctlpsh.......ttsshuplhpslupshhpssGGsSGslauphhtuhupsl.....ps.ppp........h..ssps.hupulpsuh.pulpph.u......tAcsG-+ThlDsltPsscshpp.sht.......tsh.phhptuspuA.cpuscsTtshh.sphGRAthluppsh.G......hsDsGAhuhshllcuhtp	...........................................luDGDpGsNMstuhpustcplpst.....................spslu.....plhpshutslltsstGsSGslh..........uphFtuhupsl..............ps..ppp.................l...sspp.lup.u..hpsul.suhpuh.........scss-tThlsVhtss....scuhpp..utp................tts..h.t.............h....h...ptshcsAcpuh.ppT..shl..Ath..GRA..........G.......hlDsGupuhhhlhpuhh.p.....................................................................	1	338	633	857
+1724	PF03045	DAN		DAN domain	Bateman A	anon	Pfam-B_1968 (release 6.4)	Domain	This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges.  This family of proteins has been termed the DAN family [1] after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling.  It is postulated that all members of this family antagonise different TGF beta Pfam:PF00019 ligands [1]. Recent work shows that the DAN protein is not an efficient antagonist of  BMP-2/4 class signals, we found that DAN was able to interact with  GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo [2].	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.34	0.71	-4.70	20	362	2012-10-02 16:54:34	2003-04-07 12:59:11	10	7	107	0	209	428	0	113.40	30	56.02	CHANGED	phhpctlhctsttu.....hshppp.h+pshC+shPhpQpl.sc-GCcshsltNphCaGQCsSaalPpp...t...........hpsCupChPs+hpthplsLpCsups.s......hKcVhhVccCpCpssppc	...............................h.....................h.thh.h+pshC+spPlp.Qsl...pc..p...G...Cpu.p.s.l.N+hChGpCs..Sa....h..l...Ppp......ptts...............................hppCsp.CpPtchphhhVsLp.CPshps.s.p...........hK.pl....tpl..c..pCpC.sh..t........................	0	42	63	121
+1725	PF01266	DAO		FAD dependent oxidoreductase	Finn RD, Bateman A	anon	Prosite	Domain	This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.02	0.70	-5.55	530	27418	2012-10-10 17:06:42	2003-04-07 12:59:11	19	195	4663	179	8594	47340	28561	332.00	16	72.99	CHANGED	-llllG.uGlsGhusAhpLuc.........pGh...pVsllEpp.phut..................................usS...s.ts..uGh..lpsth.....................................................pts..hh.hp.hs.hpuhph....hpp..............................................................................................h.....hpph...................shs....h.....t.h.ptGtlhls.h.......sppp..hp..th.............tt.hp..hhpp.tsh......thc.....hlstp.phtph............................s.hs.....s.........th........hu...............u........lh.hsssu.hl..cstphstult...p....................t..s.t..p.t......G..sp......lh...ppsp.....V............psl......pt..psst.............................................ht.lp...............................s.....t.pu........p.hps.............ctllhAs........Gs....as....sp.l.ht.h.sh............................................l...........hshcu....h..lhhp.......s................htt...h.....................h......h.........................................................t.hhh...........hh............................h.h.............h..........................................................s.tp..sp.......h...............hs............sshsth.............................................t................................................................t.......................tl.......................................................................h..ptht.......phh...Ptl.............................................tpspl.htt......a.sG.........................................................................................hc....sh..s.......................................................................sDth.............................................................hhtt....ht.slhhs..tGhss................Ghth....usssGc.hluph	.....................................................................................................................................................................................................cllllG....uGlsG..h..u..sAhtLsp..........................tGh......pV.s..l..l-..t...p...t...h.ut.................................................................s..s....o.........s...t...s.........s.u..h..l.tst.......................................................................................................................................ttt.....h....h...h..p.....h......s.........t.....u...h....p..h......h.t.t........................................................................................................................................................................................................................................................................................h................ht.p.h......................................s...h..t.........h..............t........h.....................u.....h......l....h..l....t...h................p.t..t.p.........ht.....h........................................t....h.......t.........h.....t.t.......hsh..................th.p.............................h..l...s.....t...t......p.....h....t..t..h........................................................................s.ht......t.....................h..................h.s..............................u..............h.h.........p..s...s......h.....p.......s........t.....p........h.....s...h.....s....h.h....p...........................................................................t...s..t..p..t......................G....sp....................................l..h....t.t..s...p........V................p.s..l..........tt....p...s..st.............................................hh....l..p.........................................................................................................................s......t.p.s..........................p..lpA..........................ct.l..l...........A..s...................G....s............h..s..........tp...l...h.t...h...t.h...............................................................l...........hs.....h....c..u.........h...h....h.ht.............................................t.t...h...................................h...............................................................................................................t..........h................h..h.h..........................................h.h.........t....h..h..hu.......................................................t...tt......h...........h.s.............s.s.........................................................................t..................................................................................................................................t.th.......................................................................................................................................................................................................................................................h....p..t..h.......p.h...h........P..t.h.....................................................tt.h...p.h......tt........h..s.G..............................................................................................h.h...........sh....s.......................................................................s-th.....................................................s.h..s..t.............................h............s.....h........h...hs.......u..hs..t...........................G..h....t..h....u.hhup.hhs...................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2308	4853	6950
+1726	PF01678	DAP_epimerase		Diaminopimelate epimerase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_2089 (release 4.1)	Domain	Diaminopimelate epimerase contains two domains of the same alpha/beta fold, both contained in this family.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.47	0.71	-4.20	28	7321	2012-10-03 03:02:41	2003-04-07 12:59:11	14	6	3504	42	1855	5624	4219	119.90	25	83.62	CHANGED	hshspGsspshlhls-hcp...tshhp.......hsttlps+pthssusslhalp......sssctclphR..........lapssuuEsptCGsG.stshuthlhptth......tppslpVcs.uG.lhlplpsssp.....hh.hGssphl	.......................................................................sh.hGsspshhh..l....D..s..h..sp...........ts.h.s...........................hu..t.l..p..s..+...p.....h......h.....s........s.t.s..s..lhhlp.........................hssc.s..c..h..chR................................lap.p.s.u.u..EsptCGsG...st...s.s..u...th...l..t...p...t...t..h..................tpp..p..l..p.Vps.....u..G.p....l....t..l..p.h..p..s..sst.............hh.hG.s........................................................	0	612	1251	1586
+1727	PF05173	DapB_C		Dihydrodipicolinate reductase, C-terminus	Studholme, DJ	anon	Prosite	Domain	Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate.  This  reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The C-terminal domain of DapB has been proposed to be the substrate- binding domain.	20.80	20.80	21.00	21.10	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.70	0.71	-4.38	189	4343	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	4160	36	1018	3039	2348	134.50	37	51.96	CHANGED	GlslhhplscpAAchhss....aDlEIlEhHHppKhDAPSGTAlplu-slspst......................t....pt.thhs.p............sp.IslpulRsGsllGcHpVhFsutsEplplpHcAhsRp..sFAtGAltAAcal....h...s.p.....G...lYshpDlL	..........................................Glslhhclhc....pAA.+.h..hss.....hDlEIlEhHHccKlDAPSGTAlphuEsIAcsh................................spph....tt..thhsccth............ttts.ssIshpolR.u..G..slV.Gc..HpV.......hFus.tGE..p..l..p..IpHcAt.s.Rt..sFAsGAlpAApalt.........s....+..........sG......lYshpclL..................................	0	327	676	865
+1728	PF03344	Daxx		Daxx Family	Finn RD	anon	Pfam-B_3933 (release 6.5)	Family	The Daxx protein (also known as the Fas-binding protein) is thought  to play a role in apoptosis, but precise role played by Daxx remains to be determined. Daxx forms a complex with Axin. 	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	713	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.35	0.70	-6.04	7	169	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	84	2	75	167	0	470.80	32	71.69	CHANGED	hAhsDsIIlLD.DDDtEEtsspPusS.sss..sts......ph..PKlpQPhsscIstusssou++csasLpsENpKLFpEFV-aCpspTpDpPEVlsFL+s+puKASPpFLuSVEF+NhLuRCLoRAQu+RoKsaVYINELCTVLKtHSsK++...lplpPsuups.....tp.t..PT-sh..s.......................Sup.pspc-p....tt-tppp+uSRRQItYLENLL+hYscEI+RLQEKELSLpEL--EDSoYIQEu+LKRK............................Lh+IapKLCELKGCSSLTGRVIEQRIsYpGTRYPElNRR....................IERFINtPEupps.PDYsDlLptlp+ANERHuLsLoRKQLpthAQDAFRElGsRLQERRHLDLVYNFGSHLTDsYKPusDPAL.DPoLAR+LRsNRplAlS+L-pVISKYA.hQD-TEEtERpK.RpE+ctpsspup.....tp.shtsssuspuP.hhtup-s.sppps-p-p-----.pp..p........psptt.--.-EE-pE.psssc.-p-h-sus-upusspEccpstp................................ttp..+..ohsspSPpspPtps.sh-.p..sEppcpphltp-pslSsHhphstluhs..............ppphsPsslshsLppsusshhopopsussoscsspppss.pt+pRpc+..........c.htut.hhsusl......h.csGpchp.LPhshsslsS.ushpspSopsDoPopt.sTso..........pTP..sPh+s...KlsVATQCDP-ElIVLSDS-	.....................................................................................................................................................................................................................................s...altShtFpshlspshschptp.tp...haValpplss.Lpt...ct....++p..........p...h..sssptt............ss.....shp.............................................................................................t..pp.............ttpt.pppt.pc...c...pIthLpph..LthhstcIp+LpctElshsp.pc.D....SsYlp.t+hK++............................hhplat+lC-Lpspss.ssRhlcp..I..a..puTcYPclN+p.........................lpphlNp................ps.............hPDYtDlLphlp+........sstccsLsLsc..pphp.h..Ap..-AFpclG.hLQcRR+.DhhYshu..sHlTss.....sh..DPAh.Ds.Lhp+LcpNppht.s+lp-llpKYu.hQ-.p...ct...ptph.p..tc......tt...................pt..tt.......tt.......t....t...tt.t....t................................................tt...ptt........t..........t.....................t.................t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	23	28	50
+1729	PF02277	DBI_PRT		Phosphoribosyltransferase	Mian N, Bateman A, Moxon SJ	anon	Pfam-B_5739 (release 5.2)	Domain	This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin [2].	22.60	22.60	23.00	22.90	21.50	22.50	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-12.10	0.70	-5.34	26	2551	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	2248	35	647	2021	520	317.80	35	85.49	CHANGED	llsplsssDstshstspp+.spLTKP.GuLG+LEpluhpluuh....pGps.P........sls+s.tlhVhAusHGVstpGVoshPtpVTsphlpNhht......GGAuIshlsppsGssl..c....VlDlulct................csoushsptsAM..occcsttulthGhchhtp.hstGs-LlshGE.hGI.GNTTsAAAlhuuLhGssspphVG.G.oGlsspsh..........p+KhslVccAlt.hppssh...sDPl.-lLsplGGh-lAAhsGhhLuAAhp+hPVllDGalssuAAllutp.lsPtshcahlhuHhSsE.GHthhLptLuhcPlLsL....shRLGEGoGAsLAhslVcuAsthhptMuTatpAsV	......................................................................................................................h....l.s.D.tt.hh.ttspp+......ctLsK.P.G....SLGpLEpluhp.lAuh......tup.t..s.....................pltc...tlllhuuDH.G..Vh.t......c.....G..Vos..h.P....ppV.T.t...t...hstN..h.h.t......Gsu..ulssluppsGs..p..l..p....VlDl.Glsss....................................................hph+ltpG.o.sshs....ptsAM....o..p..cp...s..ttulttGhphs.pp..h.h..........p.p.G.s.s.l.......lsh.GEhGIGNTTsA..uA.lhuslsG....h...............ss..p....p.....s....V.....G...h....G....s.Gls.s.st.l.............t+KhsllccAlp.....hp...p....s.ps.................pD....sl......-......lLu.plGGh-lu....uhsGshLuAA.p.p..p..hP...VllDG.Flss.uA..A.L..s.A..s..p....l....s....P............ss......psahlsuH.hS.sE......Gt....ph.hL..ptL...........u...........h............c...P...h...L.sh.....shRLGEGoGAs..LAh..sllcuAsthh.s.pMushttutl........................................................................	0	206	432	555
+1730	PF03880	DbpA	YxiN_DEAD; 	DbpA RNA binding domain   	Bateman A	anon	Kossen K	Domain	This RNA binding domain is found at the C-terminus of a number of DEAD helicase proteins [1].  It is sufficient to confer specificity  for hairpin 92 of 23S rRNA, which is part of the ribosomal A-site. However, several members of this family lack specificity for 23S rRNA. These can proteins can generally be distinguished by a basic region that extends beyond this domain [Karl Kossen, unpublished data].	23.10	23.10	23.20	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.86	0.72	-4.31	173	3567	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	2412	2	811	2655	411	73.50	30	13.56	CHANGED	sphplslG+ccplcPtslluslsscu.slss.ppIGpIclh-paoaV-lsps.hscphhpplp..psplp.G+plplchh	.........phpIssG+c.cp.lcstcIlGAlss-u..s...lsu...ppIGpIclhs..s..aohVplspu.hspcslpplp..ps.+Ip..G+phplph.h........................	0	257	512	682
+1731	PF04290	DctQ		Tripartite ATP-independent periplasmic transporters, DctQ component	Mifsud W	anon	COG3090	Family	The function of the members of this family is unknown, but DctQ homologues are invariably found in the tripartite ATP-independent periplasmic transporters [1]. 	27.10	27.10	27.20	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.66	0.71	-4.39	186	5361	2009-09-13 06:40:50	2003-04-07 12:59:11	7	9	1674	0	1467	4565	5259	134.30	19	65.70	CHANGED	hhhlhhhpVlhR..hh....h.....t.shs.h.spE.lsthhhlhhsh.luhuhshpcspHlplcll...hptl.ssphpthhp.hlssl.lshs...hss....hlhatuh...................................hhhhhtttptssshs...lPhhhhh.....hs...lsluh..slhsl...thl.hplhph.hps	.................................................shllhhpVlhR....ah......h..............................spshs..h..s....-E.lst.hlhshhshlG.uuhsh.t..p.st.H.l..pl-hl..........hp.tl...ssp.h...pp..h...lp....l...lspl...lhlh....hsh..................hlhh.huh..........................................................hh.s.h.ht.h.s.p...h..o.ss.hs............ls.h.h.h.hh.............hs...lsluh....slhh.l....htl.tplhp.h..t.........................................	0	440	995	1263
+1732	PF03605	DcuA_DcuB	Dcu; 	Anaerobic c4-dicarboxylate membrane transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.70	20.70	20.70	21.30	20.10	20.60	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.29	0.70	-5.62	10	2671	2012-10-02 15:12:49	2003-04-07 12:59:11	9	3	1383	0	245	1239	66	350.30	44	83.13	CHANGED	ElllVLlslFlGARhGGIGLGlsGGlGllILsFshtlsPus..hPlDVhLIIhAVluAuAsMQAAGGLDahlQIAEKlLR+NPKplTlLAPlVTYhhTlhuGTGHsVYSlLPVIu-VAhcsGIRPERPhSsAlVuSQlAITASPISAAVVhhlAhLss......pulshLoLLtVsIPoTllGsllhulhsh.hpGK-LccDP-YQcRLscshh+phshspp......clssoAKlSVaIFLsullslVlhAsssslpsuhh..s....psluhshsIphFMLssuuLIllhTKlDsssIspusVF+SGMhAslslaGlAWLuDTahssHlspIKsshupllpsYPWhaAlsLFllShllsSQAATstsLlPlul.ALGlsP	..........................................................pllllLlslalG.ARh.GGIulGhhGGlGlllL.s.h.s....ht.lpP..Gp.......PhDVhLlIhAVluAhushQsAGGLDhhlplAE+lLR+NPKaITllAPhVTahhTlhsGTGHlsaohLPlIs-VAhcpsIRPpR.PhuhusluuQhuIsASPlSAA.VVhh.s.u..h.Lts.........tsl....s....al..plLulsIPoTllulhlhuhh.s.h......hhGp.-.....LscDs..YQcRLpcs.h.cthshtpp...............cl.p...sA+hSlhlFLhu.llsVV........lhushss................ps...........uhs..............p................slshstsI.hhMLssusLIhllsKss.sspIs.ssslF+uGMsAslsl.hGlAWhu-Tahs..u..phs.IKsshupllp....saPWhhAllLFhsStll.SQAATstAlhPl.uL.ALGlsP..................................................	1	41	118	193
+1733	PF03606	DcuC		C4-dicarboxylate anaerobic carrier	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.46	0.70	-6.26	13	3902	2012-10-02 15:12:49	2003-04-07 12:59:11	10	5	2105	0	339	3372	265	444.50	24	97.14	CHANGED	hPthhsllhhlhlhhhIlohahPsGsatpts..................................hl.hhhsshhspspslssshtssttthhs..hhphshh.hpscAsslshFIhhlGGhhulls+oGAh-sslttls....KhhptpcphhIhhlhshFshsssshGhsEto...lshhslLhPlhlslGasthsususlhhuossGhhuuThNPhslVlAupsAGlslt-GhhhRllshslhslluluasaaYsp+lpccP......hpp.cEppphhphcpup.sss....ssthhhhLhhhshlhhlhu.........h.h.hls.....................paahsplsslalhhulllsalth...hsshpsp-hhpuFhcGhuchh.sAhlVuLA+Gltlhhpss.....hhlsTIlshhssuhoshsu..lhhllhhllhhhhuhllsSGSG.AhhoMslhsPLAchlGlstshlllshQhusslsphluPTSGlVhAsLuhu+luhtpWlKhsus.lshhlllshlslllthh	...............................................................................................................................................................................................hhsllhh.l.hlhhhlhphhh..PsGhh.h.t.........................................................................................h.l..h..h.h..s..s...hh...t.t.......t....sl..s.....s.......t......s..t.......t....hh...s..........................th............h...........hhs...puss...lh.h.h.IhhlG.G...h..h..ul.hp.+oG...A.-sslt.tl.s............+......h...p...........s...h...c....h...h..I......h.l..h..h.h.h.sh..s.s......h.s.h.uhs...p..ts......l.s.h.h.s.h.L.h.P....l....h.ls.lGhcs..........h.su...sus.l..h............hu....s..t..h.u....h....h..u............s....s....h............s.....................s.......s.......s....l.......A..........u...........p.......h......A.......G..........l........s.....h....h....s....s....h.......h.......h........+.......h....l...h...h.......s...l....s...s....l..l..s...l..h...h...s....h...h...a...s....p..+....h....p.cc...............................p.........t...c....p....t.......p...t....h..t..h.....p...t....s....p.........p...p.......p......hp.........t...p...t......h..h..h....l.....l...h..h..s..h..l...h.....h.l..h.u.......................hhhp................................................................................th.ah...s..p.h....s....s....h.....h..h...h..h..u.l...l..l.t.h.lt.........s..h.p...p.shhps.F...h...c.Ghu...s..h...............s.......Ah.l.V..u...l...s.h..u..h..t..l..h..h...p...sh.................hh.h.s...o...I...h...s...h....h...s..t...s...h...s...s...h..s.....s....h......l...hh..l...h..h..h..l..h..h.......h..l..huh.hh.sSuou.uhhhhs.l.hs.P..L..A....c.h..s.......G.....ls...t....t........h..h...l.h...s....hphusshsph.lsPs...o..............u....l....l..hushu....h..u.....+.........l.....s....h.h...p.hl.K..h...s..u..s..h..l....h..l.h..hl.h.sh.lhhhh...h..........................................................................................	0	106	193	281
+1734	PF03184	DDE_1	CENP-B; DDE;	DDE superfamily endonuclease	Mifsud W, Bateman A	anon	Pfam-B_2254 (release 6.5)	Family	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localised to the centromere.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.35	0.70	-5.20	20	3031	2012-10-03 01:22:09	2003-04-07 12:59:11	14	109	208	0	2383	3243	38	158.50	17	38.69	CHANGED	hsscslaNhDETGlhhshhsstt....s..ttpth.stpt..pcchTshlsssusuuc+L.PhlIhKups.cshph..................htpshshpacssppuWhosplht-WL.chFssphp........s.sc+hlLlLDuasuH..ssph......hhpNltllalPspsopllQPhDhGlhsshKtpYRpphhphhltstsshps...........................t.shhchlchhtpAWp.ulspcsItsua	..................................................................................................hhsh.c.p.....h.....t.................................................................................p......p...p.h..h.hhh...s....ts..s..s...hh.........h.h.lh...t...t....t........................................................................h......h..t......p.t...pu.a........h.s..p.......t..hh..t...ah......p...h.....h.....ht......................tp....hhL.lhDs.....h.ts..H....s.th........................t..p..l.....h.h.h.....h........P........s.........p.s..op......h.............h............Q............P.......h.....D......h.....s.....hht.sh.K...th..h.t.t.h.......t.h.........................................................................................................................................................................................................................................	0	825	1401	2161
+1735	PF02862	DDHD		DDHD domain	Bateman A	anon	Bateman A	Family	The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues.  This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3) [1]. This suggests that this region is involved in functionally important interactions in other members of this family.	23.30	23.30	23.70	23.30	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.45	0.70	-4.56	51	906	2009-01-15 18:05:59	2003-04-07 12:59:11	12	34	250	0	612	855	0	183.70	25	23.63	CHANGED	LcFcscshFhhGSPlGhFhhl+ttph.sp.............................................s.ssphspPsCcplYNIFHPsDPlAYRlEPLlssphup.lcPh.lPptppt.hhtht........................................ctlsslusphptsht.......................ht...h.pt.s.stpspp.tpsss.pph...............................................................................p.pppp.ppp....tttphphttLNsst......RlDYsLp.tu..sl-..spalsslsuHsSYWpspDsstFllpplhp	................................................................................................................................................................hpFcspthFhhGSPluhhLhl.+th.t.......................................................s.......hs...tCp.phaNlaHshDPl.AhRlEPhl..pht.......l............tPh..lPh..hpt.h.h.hp.ht.................................................................................................................................h.pthttt....h..............................................................................................................................................................................................................................................................................................................................................................................................................................h..h.thh...t..s..t...............RlDa.L....t....lp......ph.h.sh....HhsYWpstDsshhllpplh..........................................................................................................	0	170	259	468
+1736	PF03345	DDOST_48kD		Oligosaccharyltransferase 48 kDa subunit beta	Mifsud W	anon	Pfam-B_3520 (release 6.5)	Family	Members of this family are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST), also known as oligosaccharyltransferase EC:2.4.1.119, transfers the high-mannose sugar GlcNAc(2)-Man(9)-Glc(3) from a dolichol-linked donor to an asparagine acceptor in a consensus Asn-X-Ser/Thr motif. In most eukaryotes, the DDOST complex is composed of three subunits, which in humans are described as a 48kD subunit, ribophorin I, and ribophorin II. However, the yeast DDOST appears to consist of six subunits (alpha, beta, gamma, delta, epsilon, zeta). The yeast beta subunit is a 45kD polypeptide, previously discovered as the Wbp1 protein, with known sequence similarity to the human 48kD subunit and the other orthologues. This family includes the 48kD-like subunits from several eukaryotes; it also includes the yeast DDOST beta subunit Wbp1.	36.00	36.00	36.20	46.60	35.90	35.40	hmmbuild  --amino -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.42	0.70	-5.95	29	360	2009-09-11 12:44:55	2003-04-07 12:59:11	9	6	276	0	243	382	1	379.40	35	87.94	CHANGED	sLV........llDstsp+tp.........aShFapsLcs....R.GacLsacssc..s..ssLsLachGEhhYDpLllFssp.s+shGss..lo.scsllcFlssGGNlLlssSup........hsculRplhpEh.slch.s-csshllDHFNaDst.sss.pHslll.....h.tsshlpssspshht......tslha.+Gsuthlss..ssLlhPILpAspTuY.......SYs..scpchpsh..........sausGpQshLVuuhQuRNNARhsasGSh-hhpDcaFsutspt..............posNp-FAcplopWsFpEpGVl+lsplpHa+ts-st............sP.phYpIK-plhYoIplsEa.....sps+WlPFp....s-DlQLEFsMlDPahRhsLp...........tpp..tsushYos.pFplPDpHGlFsFclsY+RsGhTplpcpspVoV..RphsHsEYsR..hIsuuasYhuuhauslsGalhFshlaLappss...........KKpp	......................................................hLVll-s...s.+pp........aShFapsLps.........................RGa..pl.sacsscs......spLsLhchGphhYDpL.l.lhssp....sc.p...........hGss..ls...spslhpFlcs.G.GN.....lLlA.soss.........hscslRplhsEh.Glch.s-csshVlDHasYcst..........s.s.pHshll................h.sps.h...l.p..ssshst.tt........sslha..+GsGhshss.tNsLlhslLpAs.sTuY............................Shtscpthpph...............shssGp.phhLluuhQ.....AR.NNARlshsGSl-hhoDpaFsutlpt.........ttp..pouN..tphupplopWsFpEpGVL+ls.slpHa+sscst.........................sP.phYplpDpl..................pYoltlpch.....ssscWhP.ap..........sDDlQLEFshl-PahRh..sLp..........................psuhYps.pFplPDhaGVFpF+VcYp.R.GhTpl.ppppVoVR..htH.spY.R..hIsuAaPYhuusaShhhGhhlFshlaLa.p...............p.........................................	0	87	137	203
+1737	PF04625	DEC-1_N		DEC-1 protein, N-terminal region	Kerrison ND	anon	DOMO:DM04594;	Family	The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1].  Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa).	27.90	27.90	27.90	58.00	24.90	27.80	hmmbuild  -o /dev/null HMM SEED	407	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.41	0.70	-5.79	3	34	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	13	0	12	48	0	338.70	58	37.51	CHANGED	MMFPALGSLLRWGSLFPAYSILGAIPDNLQPTAAASKVVLVLADDATAKTRVARQNPPPNPLGQLMNWPALPQDFQLPSMDLGPQVGSFLAQL...PAMPo...MPGLLGAAAPVPAPAPAPAAAPPsAPAPAADoPAAPlPDAsQPAILGQAALQNAFTFLNPSNFDASSLLGQSVPTFAPPNLDFVAQMQRQFFPGMTPAQPAPAGTDAQASDISEVRVRPEDPYSQEAQMKIKSALEMEQERQQQVQVKDQEQVPLLWFRMPTTQNcDATEEKTLEDLRVEAKLRAFERQVIAELKMLQKIELMAKQMRSSAAAQNGDSPYRISYPLSRTPIHKITRADIEQALRDDYVRRLVNKEAQRKARNSGINTQKANALKRQAKSQDQTLSKEDIVQIMAYAYRMANEQMESEKG	.....................MMFPALGSLL+WGSLFPA.SlLGAlPDs.L.....QPtAAASKVVLVLADDAs.uKoRVsRQs........sP..PsP...h.Gph...MNhPAL......PQsF.....Q....L...so....M.sL.s...PpVGp.hL...u..QL.Ps.MPs.....hsul..LGtAsPV.Pss..........APAsss...sPs.AssPAs-sPs..sssP..ss..s.Ps....ushtsuhsFhsPuNFDuS.sLLGQu...lss.....................APP.shDFhuth.RQFaPGhsPA.pPusu.soDAQASDISEVRVRPE........s.............s...a...uQ.pAQ...M...KhKSALphEQE+Q........cspEpVPLLWFRMPo.......opsp..-ts-pKolE......DLRVEAKL+AFERQVIuEL+MLQpIEhMAKpMRoSA...suQss..soPY+lsYPLSRTPlHKITRADIEpALRDDYVRRLlpKEAQRKu....tsp......tsuhKRQstpQ.-QshSKE-IVplMAYAYRMAsEQh.Ep...................	0	3	3	7
+1738	PF04624	Dec-1	DEC-1_REPEAT;	Dec-1 repeat	Kerrison ND	anon	DOMO:DM04594;	Repeat	The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1]. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). This repeat is usually found in 12 copies in the central region of the protein. Its function is unknown.  Length polymorphisms of Dec-1 have been observed in wild-type strains, and are caused by changes in the numbers of the first five repeats [2].	20.90	20.90	21.20	20.90	20.30	20.70	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.71	0.72	-4.31	7	107	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	8	0	43	192	0	26.40	68	12.46	CHANGED	QNsMMM.p....RQWoE-QAKhQQp..QQMhQQ	.QNPMMMQQ...RQWoE-QAKlQQs....Q.Q.hQQ........	0	24	24	37
+1739	PF02352	Decorin_bind		Decorin binding protein	Bashton M, Bateman A	anon	Pfam-B_800 (release 5.2)	Family	This family consists of decorin binding proteins from Borrelia.  The decorin binding protein of Borrelia  burgdorferi the lyme disease spirochetes adheres to the  proteoglycan decorin found on collagen fibres [2].	24.60	24.60	95.30	94.90	21.60	20.90	hmmbuild  --amino -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.68	0.71	-4.17	12	159	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	30	0	2	132	0	139.20	56	78.15	CHANGED	KhtLESSuK-IpDEIsKI+K-AtscGVNF-AFpsspTGSKVupss.hIhcAKl+shslstKFlpsIEEEAhpLKEsGu.Sup......FpuMYDLML-lutsLEclGlppMppoVoptAcpsPsTTA-GIltIspthcsKLppV+pKQ	..KltLESSuKDIpDEIsKIKK-AsspGVsFcAFT-scTGSKVo......ps......s...hIh-AKlRAhslsEKFlpAIEEEApKLK-oGu..SGc......FSAMYDLMLEVScsLE-lGlpcMppTVo-AAcpsPsTTA-GlLtIAptMcsKLppV+pKp........	0	2	2	2
+1740	PF01335	DED		Death effector domain	Bateman A, Finn RD	anon	Bateman A	Domain	\N	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.56	0.72	-3.86	37	947	2012-10-01 21:41:45	2003-04-07 12:59:11	16	55	86	20	419	826	0	81.10	24	27.28	CHANGED	aphhlhp.lscsLspc-lcsLhFLsp...c.lspsc..hpp.pshh-lhhp.Lccpshls.ssl....shLtclLtplsRhDLLptl.phcppsh	.........................ahthLhp.lu-pLspc-lp.sL.p..FLhp......-.h..lsppc.............hpp...pssh-lhhp.Lccps.hlsp..ssl....shLpclL...ppl..p..RhDLlppl.phcpt.................	0	158	186	257
+1742	PF00711	Defensin_beta		Beta defensin	Bateman A	anon	Pfam-B_675 (release 2.1)	Domain	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.44	0.72	-4.02	54	464	2012-10-01 20:50:19	2003-04-07 12:59:11	14	4	80	69	141	484	1	34.50	32	54.72	CHANGED	s.hpChppsGhCh.tpCssthp.pIGo..Ctssth+CC+	......hpChtptGh.C.t.hhCs.hhhp.plGs..Ct.sshhp.CCh....	0	4	4	18
+1743	PF00879	Defensin_propep		Defensin propeptide	Bateman A	anon	Pfam-B_517 (release 3.0)	Family	\N	21.00	21.00	21.20	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.53	0.72	-4.01	23	253	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	31	0	76	259	0	49.60	48	52.36	CHANGED	MRTLsLLuA.lLLlALQsQA-slQtps-Es.ssQ-QPGtEDQDlulSFssscuo	...M+TLsLLuA.lLLlALQsQA-...sl.......Q.s..ps-.......Es.ssp-QPGt--QslulSFstscs.............	0	9	11	16
+1744	PF00323	Defensin_1	defensins; 	Mammalian defensin	Finn RD	anon	Prosite	Domain	\N	21.40	21.40	21.60	21.50	20.10	21.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.88	0.72	-3.58	11	136	2012-10-01 20:50:19	2003-04-07 12:59:11	14	3	22	60	56	185	0	29.00	47	32.72	CHANGED	ChCRpt.tCttpERthGsCplpGhhashCC	.CaCRth.sCtttE+hsGoCp.ht.Ghhaph.CC	0	5	5	8
+1745	PF01041	DegT_DnrJ_EryC1	DegT_DnrJ_EryC1_fam;	DegT/DnrJ/EryC1/StrS aminotransferase family	Finn RD, Bateman A, Parkhill J	anon	Pfam-B_239 (release 3.0)	Domain	The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA Swiss:P72454, StsC Swiss:P77952  and StsS [1]. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyses the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.04	0.70	-5.42	38	8204	2012-10-02 18:26:03	2003-04-07 12:59:11	12	29	3491	78	2089	27677	18092	342.00	27	92.75	CHANGED	sthsp-.httlppslcus.hhhs......GshlppFEccFAsahG..staululsSGTsALhLALtA...hulu......GDEVIsPuhTFsATssslhtsGApPVFVDlD......ssTaslDPstlEsAITs+T.....KAIlsVHhhGpss.DhssltclAccauLhllEDsAcAhG..upapG...................+hlGshG..chusFSFassKsl.osGEGGhllTsDscLscphc........th+saGhs.........ppahpph............hGaNh+hs-lpAAlGlsQLc+l-phlppR+chsphapptLtslshh..hshsspss............tuaahaslhhptp....s.RcpLhptLppp..slsoplha......s.Ph+tpsh.........appht.tss.thPsu-plspcslsLPhassls...s-clccVssslp	..................................................................................................................p.hthltps.lpos...hl.s.s.............G.s..h.s..p..p...h..E......p....t......h..s....p...a........h........G..........s........p.................a.........s.........l........s.........s........s.........S.........u....T....s....A..L...p.l....A...Lhu....................ls...lt.......................G...D....E..V...I....s......s......u......h......T.....F......s........A........T.....s......s.....s.....l......h........h......h........G........A.....p..........P.....V......F.........l......D.....l.....-.............................c.....T.....h.....s.....l....D....s.....p.....t....l............E...t....s....I.......T........s.......+...T.........................+...A........I......l.......s.......V.......H.......h.......h........G.......t........s.......s.......-.......h.......-.......t.....I..............h.....t.....l...............u....c.....c......a................s.................l..............h.................l.l..E.D......u...A.....p....A....h.G.....u.....p..a.....c..G...........................................+.t..s..G......s..h..G.......c....h.u.s.a..S......F..a...s......s...K.sl....ssG..E.....G....G.h.l......h......o..s......c......p......p......l.h...c..c..hc...............................................hl.p..p.p...Ghs.................p.p...h.htph....................................................hG..hN...h..+...hs..-l...p...AA..l.s....h....s.....Q....L...c.p.......l.........-..p.h.....h.p.pR.....p..p.l.sp...hY.....pp.t.L........t....s...h...s...........h............h..t.h..s..stsp.........................................psaa..ha.h.lh...l..............p....t.................t................................................p......Rs........t.....l.h.ptLppp.............sI...t.s.....t.h.aa................hsh.a.t..p.sh..............................a.p..p.....h.....t....................................p.....h.s........scp.ht.p.p.hlsL..P..hast.hs...ppp.hphlhpth.h..............................................................................................................................................................................................................................	0	739	1465	1821
+1746	PF02286	Dehydratase_LU		Dehydratase large subunit	Mian N, Bateman A	anon	Pfam-B_7927 (release 5.2)	Domain	This family contains the large subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.	25.00	25.00	41.80	41.80	17.40	17.00	hmmbuild  -o /dev/null HMM SEED	554	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.61	0.70	-6.26	11	398	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	338	20	44	238	19	512.60	77	98.83	CHANGED	pRpKRFchLscRPVN.DGFltEWsEpGhlAMsSPNDPKPS.lKI-NGpVlEhDGKttpDFDhIDcFIAcYuIslspAEcsMshDSlclARMLVD.NVsR-EIlclTouhTPAKlsEVVupLNsVEMhMAhQKMRARRTPuNQAHVTNh+DNPVQIAADAAEAulRGFcE.ETTVuVsRYAPhNAlALLVGSQsGRsGVLTQCSlEEAsELcLGMRGhTuYAETISVYGTEpVFTDGDDTPWSKAFLASAYASRGLKMRFTSGuGSElhMGaAEGKSMLYLEARCIhlsKuuGVQGLQNGulSCIGlsGAVPuGIRtVLAENLIshhlDLEsASGNDQsFSHSDIRRTARhLhQhLsGTDaIhSGYSulPNYDNMFAGSNhDA-DaDDY.lLQRDLtVDGGL+PVsEE-lIulRpKAA+AlQAVFctLGLPsITDEEVEAATYAcGScDhPpRssVcDlKAApplhsRGlTulDVVKALucsGFsDlAEslLshh+QRloGDYLQTSAIhD+capllSAVNDsNDYtGPGTGYRL..otERW-cIKslstAlcsp-lc	.....MRSKRFEsLAKRPVNQDGFVKEWlEEGhIAMESPNDPKPS.IKI.NGtVsELDGKshu-FDLID+FIA+YGINLsRAEEVMuMDSVKLANMLsDPNVpRs-IV.LTTAMTPAKIVEVVSpMNVVEMMMAMQKMRARRTPSpQAHVTNlKDNPVQIAADAAEuAhRGFDEQETTVAVARYAPFNAlALLVGSQVGRPGVLTQCSLEEATELc...LGMhGaTsYAETISVYGTEPVFTDGDDTPWSKGFLASuYASRGLKMRFTSGoGSEVQMGYAEGKSMLYLEARCIaITKAAGVQGLQNGSVSCIGVPuAVPSGIRAVLAENLIso.LDLECASuNDQTFoHSDhRRTARhLMQFLPGTDFISSGYSAVPNYDNMFAGSN.DAEDFDDYNVlQRDLKVDGGLRPVpEE-VIAlRNKAARAlQAVFsshGLPsITDEEVEAATYAHGSKDMP.ERNlVEDIKhApElls+shsGL-VVKALupGGFsDVApshLNh.Kt+loGDYLHTSAII.............stDhpVlSAVNDlNDYAGPuTGYRL..pGERWEEIKNIPsAlDPs-l.s...........	0	14	25	34
+1747	PF02288	Dehydratase_MU		Dehydratase medium subunit	Mian N, Bateman A	anon	Pfam-B_7081 (release 5.2)	Domain	This family contains the medium subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.	20.60	20.60	20.60	37.50	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.27	0.71	-4.33	62	717	2009-09-11 12:54:19	2003-04-07 12:59:11	10	2	336	26	77	386	10	113.30	44	63.61	CHANGED	stPAhslhhppshss....tll+pllhGIEEEGlshcl.p.shcsuDlshhAhpAAphSs.ulGIGlpuc......ssllH.+sL.s.ssL.hhs...hhstcshRtlGpNAARhsKG...hPh.	.............s.uPAhslttssshsu.....pll+EVlhGIEEEGI.scl.c.....phcuuDVshsAhpuu+.Ss.ulGIGlpu+......osVlH.+sLPs.usL.hhs..shhs.csaRplGpNAARhsKG.....P...........	1	27	44	59
+1748	PF02287	Dehydratase_SU		Dehydratase small subunit	Mian N, Bateman A	anon	Pfam-B_6588 (release 5.2)	Domain	This family contains the small subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.	25.00	25.00	38.30	38.30	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.44	0.71	-4.43	17	370	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	338	20	44	205	7	135.80	66	81.96	CHANGED	os+p.hstsDYPLspK+P-hlKTsoGKsLcDITL-sVlsGcVsupDlRIoP-TLchQApIAcssGRsAlucNFpRAAELTslPD-RlL-lYNALRPaRSoKpELLsIAcELEspYpAslsAsalREAA-sYcpRcKL+	.......................ou.csspVsDYPLAsKHPEaVKTuTsKoLDDhTLENVLSscVoApDhRITPETL+hQApIA+DAGR-pLAhNFERAAELTuVPDDRILEIYNALRPYRS.TKpELLAIAD-LEs+YpApICAAFVREAAtLY.cRKKLK..........	0	14	25	34
+1749	PF00257	Dehydrin	dehydrin; 	Dehydrin	Finn RD, Bateman A	anon	Prosite & Pfam-B_3306 (Release 7.5)	Family	\N	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.50	0.71	-3.89	27	1293	2009-09-17 10:00:38	2003-04-07 12:59:11	14	12	182	0	114	1285	0	110.70	26	87.32	CHANGED	sshhcchGsslthssthppttttttst.........................................................................s.httptts.....................................................................ttthtthhppst...SuSSuuSE--sp.........sGc+.................................................................KKGltEKIKEKLPGspps...............t....sttssshstt..........................................................tttEKKGhhDKIK.........EKLPu..............Gpc	...............................................................................................................................................................................................................tt...........................................................................................................................................................................................................................................................................................................................................................................................................................................tpp-ptt.............................tt.c.+.................................................................................................................KK.G..lh-K..IK.E..KL.P.Gsppc.............................................................s.t...t.h.t.t.....................................................................................tpp...shhtp..........................................................................................	0	23	58	87
+1750	PF02336	Denso_VP4	denso_VP4; 	Capsid protein VP4	Mian N, Bateman A	anon	Pfam-B_19701 (release 5.2)	Domain	Four different translation initiation sites of the densovirus capsid protein mRNA give rise to four viral  proteins, VP1 to VP4. This family represents VP4.	25.00	25.00	42.50	40.10	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.45	0.70	-5.48	3	29	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	21	1	0	36	0	370.00	36	70.57	CHANGED	DVTMAMSLPGTGSGTSSGGGNToGQEVYlIPRPFSNFGKKLSTYTKSHKFMIFGLANNVIGPTGTGTTAVNRLLTTCLAEIPWQKLPLYMNQSEFDLLPPGSRVVECNVKVIFRTNRIAFETSSTATKQATLNQISNLQTAVGLNKLGWGIDRSFTAFQSDQPMIPTAToAPKYEPVTGsTGYRGMIADYYGADSTNDsAFGNAGNYPHHQVGSFTFLQNYYCMYQQTNQGTGGWPCLAEHLQQFDSKTVNNQCLIDVTYKPKMGLIKPPLNYKIIGQPTsKGTISVGDNLVNMRGAVVoNPPEATQsVoESTHNLTRNFPAsLFNIYSDIEKSQlLHKGPWGHENPQIQPSVHIGIQAVPALTTGALLVNSSPLNSWTDSMGYIDVMSSCTVMESQPTHFPFST-ANTNPGNTIYRINLTPNSLTSAFNGLYGNGATLGNV	.......................t.....hsLPGTG.u...spu..s..s.Gusspu.tp......lh.I.RPhs.s.h.s..pph.pTYpKsHKFhoFGlAsslls..s.u.T..ssss..s..s.....h.hlTTsLAEIPWcp.hhYMN.SEFcLL...P..s..GSplh-ssV+VlhRssRlAFETsSosTs.ATLNQ.p.lthAhGL..Nph.ua...GhsRpaTsFpu...spPMlPsustsspYtslsstp..tacshlt.-hYGssssss.shstssshP+HplG..hhLpsYashht..p....s.......s..p.ss........u......GWPsLsp+lppaDupsssspsll....shoYcPphu.lpsshp...h..h.hhs...P...st.us..h.....t..tshss.......hp.....t.....ssh..s.....hs.....t..t.p.s.ps..h.........s..p..........ap.....hhs.IEKuQhh.tG.h.t..psphQPSlHlGh.sV.tLTTsth..............................................................................................................................................	0	0	0	0
+1751	PF01791	DeoC		DeoC/LacD family aldolase	Bateman A	anon	Bateman A & Pfam-B_6806 (release 14.0)	Domain	This family includes diverse aldolase enzymes.  This family includes the enzyme deoxyribose-phosphate aldolase EC:4.1.2.4, which is involved in nucleotide metabolism. The family also includes a group of related bacterial proteins of unknown function, see examples Swiss:Q57843 and Swiss:P76143.  The family also includes tagatose 1,6-diphosphate aldolase (EC:4.1.2.40) is part of the tagatose-6-phosphate pathway of galactose-6-phosphate degradation [2].	22.50	22.50	22.50	22.50	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.50	0.70	-5.07	26	7750	2012-10-03 05:58:16	2003-04-07 12:59:11	4	17	3919	241	1426	4608	1164	223.40	24	84.08	CHANGED	phhhhhDpsshpsshpst..............-lcsllpcshph.......tssuVslssshlthupcthsp......clshlluhstusshsssp...........shpsccAlc.GAstlchll.ht..tscp.ppphhpclptltctCp..shslhlllE.shhpspp............p..hltcAsclst-..hGADhlKssss...........t..htsp.pssphh+csstt...................lhsSGGl.........cslcpAh...cAGA..............hGsusGRslapp	.....................................................................h..hhhlDpshhps..psstt.................clctlsppA..hp..............................tssuls.l.s.sph.l.h..h.s...t.c..th..s.t.............................pls......h....l..l...s.ast....ussh.ss.s.p..................shpsc.pA..lp...G..A..s...tlchll.ht.........tu...tp....tpphh...ppl....p....t....lhp..t..s..t.............shs...l...h..l..llE.....shl...pcpp......................t...l.hp.A.s..cl.u.tc.....hGADhlKTpss.................t...sssp.....ps....sp.h.hpchss.....................................................l..hsuG.Gl...............cshppAh..hpuGu.ph............hGs.sGhthht.t.............................................	1	479	902	1203
+1752	PF00455	DeoRC	deoR; DeoR;	DeoR C terminal sensor domain	Finn RD, Anantharaman V	anon	Anantharaman V	Domain	The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site [1]. DeorC  senses diverse sugar derivatives such as deoxyribose nucleoside  (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR) [1], [2], [3].	31.80	31.80	31.80	31.90	31.70	31.40	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.56	0.71	-4.60	91	14356	2012-10-04 00:26:15	2003-04-07 12:59:11	17	16	3216	0	1875	7048	402	159.00	26	63.33	CHANGED	tpphpcKppIActAAphlps.GsslhlDsGTTshtlActLssp........slsVlTNulslAptLtpps........shclllhGGplcppstuhsGshshphlppap.hDhuFlussGls..ctGlts.s.p-stlccthlppAccshllsDpSKau+puhhphsslsplstllTDps	.................................................h.phppKptI.Ac.t.A.u.p.hl..p..s..G...p..s.lhlDsG.oTshtl.uctLs...pp...................slsllTN.ultlA.p.h.Ltc..p................php.l.l.lhGGplc.p.....p..st..u..hl..G....s.h.shp.h.l.....p.....ph..p........hDhsFlussGls...............h......p.t...G...l.s.shs...............pc..............stlppthlpp.u..p.c.s.lll..sDpSKa..s..c..p...u...h....hph...s.sls.pl.s.h.llTDp.t................................	0	508	1030	1467
+1753	PF04511	DER1		Der1-like family	Mifsud W, Bateman A	anon	Pfam-B_1901 (release 7.5)	Family	The endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae contains of proteolytic system able to selectively degrade misfolded lumenal secretory proteins. For examination of the components involved in this degradation process, mutants were isolated. They could be divided into four complementation groups. The mutations led to stabilisation of two different substrates for this process. The mutant classes were called 'der' for 'degradation in the ER'. DER1 was cloned by complementation of the der1-2 mutation. The DER1 gene codes for a novel, hydrophobic protein, that is localised to the ER. Deletion of DER1 abolished degradation of the substrate proteins. The function of the Der1 protein seems to be specifically required for the degradation process associated with the ER [1]. Interestingly this family seems distantly related to the Rhomboid family of membrane peptidases.  Suggesting that this family may also mediate degradation of misfolded proteins (Bateman A pers. obs.).	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.32	0.71	-4.81	11	816	2012-10-01 23:21:32	2003-04-07 12:59:11	10	13	329	0	563	905	24	176.70	28	69.86	CHANGED	lPsVTRhahhusllholls+hpllsPhhLh.asasLlh+KhQlWRLhTshhaa...ushGapalhNhaFhapYsptLEpusFps+.........ssDalahLlFshlhhshhsh......................................................................ph...hhLspshshhllYlWuphNs.psplsFatlhphpApYLPalLhshshllts.ssl.s-lhGlhsGHlYa....Fhp.................hYstp.tGpcLlpTP.	...........................................hP.lTRhahss....slhh...oh...h...s.....p.h...t......l.l....s..s....h...p....lh...hs..................p.....h..lh....p......c.h...........Q...l..W.Rll....Tsh..h....a.a...................u.s.hu..h.sh.lhp..hhal....hpYs......phLE..p...s...t..F.psp...........................................uDa.h.ah..l.l.a..s.....h.hhh.hh.h.u..h..................................................................................................................th.......h..L..u..ps...hhhh.l..l.Y..l..W.....u+.p....Ns...phpls......aahl.h..sh..p.A..a.LP...a...s.hh.s.h.shl....h....ss.....s.....hh....sc.lhGlhsGHlYa.........Flp................phaP.........t..G.h..p.l.sP.....................................................................................................	0	203	316	457
+1754	PF01880	Desulfoferrodox		Desulfoferrodoxin	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Desulfoferrodoxins contains two types of iron: an Fe-S4 site very similar to that found in desulforedoxin from Desulfovibrio gigas and an octahedral coordinated high-spin ferrous site most probably with nitrogen/oxygen-containing ligands. Due to this rather unusual combination of active centres, this novel protein is named desulfoferrodoxin [1].	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.63	0.72	-3.71	58	594	2012-10-01 19:22:21	2003-04-07 12:59:11	13	10	502	39	225	540	29	92.40	38	70.61	CHANGED	osDstpEK.....HVPVIE...pspsG....VpVpVGp..lsHPMppcHaIpWI-Lhs.cpsth.......RtthpPss.............c..PcspFslph.t............................splhA.hpYCNlHGLWcsc	...........................s.sDsutEK.....HVPVlc.......htss.....lpV.p......VGp....ltHP.Mp.....pc......HaI.pW.IpLhs...s.p.s.sh..................+tpLpPsp..................c..PpApFtls.s..t...........................tsltAhpYCNlHGLWcs.p............	0	114	181	211
+1755	PF04598	Gasdermin	DFNA5; 	Gasdermin family	Mifsud W	anon	Pfam-B_5153 (release 7.5)	Family	The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form [1]. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells [2]. This family also includes the gasdermin protein [3]	30.00	30.00	30.20	31.00	26.90	29.80	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.42	0.70	-5.74	18	326	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	45	0	165	276	1	322.80	23	90.11	CHANGED	hF-+so+sll+Els..pGDLlPVssLpsus+Fp.asLVp+K+cp..hFWp.s+YhslshoLtDlLEPss.......ssPsssposs..hpapsthcsplpGslclshs.hphpluGuu...opSstsolclQplslss.th-sh..cR+lhs.cs..................shLpphp....ppt..-sLaVVTEslpTsp-sslpcsspsctpsph.lst.shslpGpuptp......pspcpsloIPpGosLAY+lhQLhl..cpcspatlslh.ccKptTFtp....................................ph..p..h..................h.....sssptpsstptshpsLcpE...lcpphpsLscLscphppsLhssltplLpDcpsLpsLEphL-th..............tltsh-ssstslLppLht..........ssshh.pphtsslhYLLsALs.LS-sQttLLupuhEhplLstphcLVculh-pshp......hs.............LpsthLusLtscth.sls.tLhtpsGlclp..tssPcssh	...............................................hFttso+shl+pls...t..GcLhPVpsL.sus+hp.hsLVh+K.pp......hhat.scah...hs..hoLhDlLpsst..............s.....p.t..t...hph.s..tsphpup....hth.........ht..hpls..Gps....s.sp.stlphpplpls..hhc........p......+.....+h.p.c....................hlpphp....ppt..psL.hVVhEhlpshpps.lp..tttphpt...t.h.......h.h.h.......h..thpsp...........hspphhltlPt.tsslAathhpLhl....p..h...th..hh..t...p...t.sF..................................................................................................................h.t....h....t.h.....Ls...p..l.t.h.t..hh...pp..h..L......ht........................t.t......h.th.................................................................h...hh.hltA.l...hsc.t..hl....h..p.t...l....p.....h...t................................................................................................................................................	0	13	19	43
+1756	PF04127	DFP	dfp;	DNA / pantothenate metabolism flavoprotein	Wood V, Finn RD	anon	Pfam-B_6559 (release 7.3);	Family	The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.32	0.71	-4.67	702	5121	2012-10-10 17:06:42	2003-04-07 12:59:11	10	12	4486	16	1366	3993	2687	170.90	33	49.56	CHANGED	LtG.++..l..llTAGPTpEsIDPVRaIoN+SSGKMGaAlApuAtptGAcVTL.l....u.GP.s.s...ls..s....P......s..l.p.hlp.VpoAp-MhpAlh.pt...h......sps......Dl.hIhuAAVADa..RP....tphus.pKI...K.K....t......sst.hs........l..pLhcsPDILt.....pl.u......ttpp...........tt.....h.lV..GFAAE..T.p........slhcpA...cpKLp.....+KshDhIlANslstts.......tG..Fus.Ds...Nplp.ll	.............................................................tshpl.llTAGsTpEsl..D..P....V..R...aloNcSSGKhGhAlApsh.hp.t..G.A....p.VsLl.....s.Gs..s..s..............l...s...............P..........t....l...p..hlp...Vpo.u...t.-.M...h.....ps..l....pt..............h.............tpt......-l.hIhsA.AV.uDap..s....................t.p.h....s..s..p.......K..l..................KK.......p.................tspths................lplh...csPD...Ilttls...t.t.t....................tp..............h.llGFAAE....T..p..........sl...phA.ppKL.t.....+.KshDhll.ANs..lst..........s...Fss.spNtlhh.......................................................................	0	450	859	1151
+1757	PF05035	DGOK		2-keto-3-deoxy-galactonokinase	Bateman A	anon	COG3734	Family	2-keto-3-deoxy-galactonokinase EC:2.7.1.58 catalyses the second step in D-galactonate degradation.	25.00	25.00	25.70	25.60	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.83	0.70	-5.66	51	889	2009-09-12 20:56:58	2003-04-07 12:59:11	7	2	751	6	148	615	193	280.40	43	93.85	CHANGED	DWGTosLRuWlhs.tsGp..llsp+puspGhtplssss............Fcss...LtsllusWhss..sshPVlhsGMlGSRpGWhEAPYlssPsshsslstthttls..s.ttsltIlPGls..ptssss.DVMRGEETQlhGsLs......psshssllClPGTHoKWVplpsGplssFpThMTGELFulLsp+SlLs+s....hssss.sss......AFtpGlppu....spssslsspLFulRuttLLttlssssutuhLSGLLIGtElAuspst..........hhspslsLlGussLsshYtpALsttGhssphls..u-pAshsGLtthsc	..........................................................................DWGoTsLRAWLh..ps.s.p...sL-pRp.u..psGlt+L....sspu.................sssLtclss......c..Wtp.......p...........s........s.P........VlhuGMlGSssGWp.APYLslPAthsulucpLssVs.......................csl..aIlPGls..........hpcs-s...sVMRGEETQLlGAht..................thussulhl.hPG.T.H.sKWVps.-......s...............t....pIscFRThMTGELapLLhp...HSllGsu..........ls.s...p...-...s...ss-........AFss.Gl.cpu....hsssul..LspLFplRAutll.G......sL......spp...psu-aLSGLLIGsElAuhpsh..............hstppsIsLlu.usuLs.uRYppAhpsh..Gh..s.s.stls..uDpAhpsGltplA.p............................	0	23	71	108
+1759	PF00926	DHBP_synthase		3,4-dihydroxy-2-butanone 4-phosphate synthase	Bateman A	anon	Pfam-B_1148 (release 3.0)	Family	3,4-Dihydroxy-2-butanone 4-phosphate is biosynthesised from ribulose 5-phosphate and serves as the biosynthetic precursor for the xylene ring of riboflavin. Sometimes found as a bifunctional enzyme with Pfam:PF00925.	20.90	20.90	20.90	22.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.17	0.71	-5.08	97	4699	2009-01-15 18:05:59	2003-04-07 12:59:11	14	20	3949	37	1250	3399	2646	192.70	49	56.26	CHANGED	lccAlpsl+s.GchlllhDD-s....RENEGDLlhuAphsTs-plsFMhppupGllClslstppsccLsLs.Mss..p......Nssth.....................tTuFTlolD.tp...s...ssTGISAtDRAtTI+tLu...........sss..spsp-FhpPGHlaPLhAcpGGVLpRpGHTEAuVDLs+LAGl.pP.suVlCEll..sc.DG.sMt+hs-..lhpaAccasLhlloIp-Llpat	.....................................l-cAlpsl+p.G+hVl.V.l.DDE.D....REN.E...GDLIhAAEthTsEpl....sFMh+au..........pGllClsloc-cscpLsLP.MVp......p......Nsssa.....................tTuFT.VSI-...stc...G...sTTGISAtDRupTlcshs.......................sss........upssDhsRPGHlFPLhApsGGVL.pR.sGHTEAuVDLs+LA..Gl.pP......A.GVlCElh............N-...D...........G...o...........MARts-..LhpFAccHsltllTIpDLlpYR.................	0	388	804	1055
+1760	PF00701	DHDPS		Dihydrodipicolinate synthetase family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_557 (release 2.1)	Domain	This family has a TIM barrel structure.	22.10	22.10	22.10	22.20	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.74	0.70	-5.81	13	10473	2012-10-03 05:58:16	2003-04-07 12:59:11	17	24	4601	330	2809	7818	5086	284.20	27	95.11	CHANGED	thtGlloAllTPFsspGplDhpuhcpLlcapIspG.s-GLlluGTTGEuhsLSh-E+hpllchsVspssG+lsVIAGsGSNuTpEAlchsppupcsGhcusLtVsPYYsKsSpEGlhpHF+sIh.stsslPhIlYNlPuRTusclsPEslt+Lup.hsNllGlK-ssGsh....thppl+ptsscshslaoG...-DspthshhphGucGsISVouNlssthhpshhctspsGchttA.ttlpc+LhPLhchLFtp..sNPhslKsALphlGlssss.hRhPhsPlsp-tptclsshlcthG	.......................................................................................................hpGlhsAhlTPF.....s..p..p.....G......p......l......D..h...p...uh.p...p.l.l.c.a...h...l......p.......p..G..s...s.G.l...h..ss..G.o...T.G..Ess..sLo..t...-......E..+.....t...pl...l....c...h...s...h.c...t...s........s.......u...........+..........l.....P.....l...I...A........G...s...G.......s..s...s...........T.p.c....u.l..p....h....s..c.p..A.p.c..h..G....s..D........ull.s.l...s.P...........a...Y....s.........+....s......o.......p......c..u....l...h....p.......H...a...c...s.......l......u.....p....u.....s.........s...l...P....ll.l..Y.....N..l...P.....u.....p...o..u..s.....s.l..s.s..-..s..l..t.c..Lu........c...h........s..s.l.l..ulK...........-....u....s....G....s...l.....................t.p...h...t....p....l.....h........p......t...........h...........s...........s........c..........h....h..l....h..sG..........sDs.h.h.h..s.h..h....t.....h...........G...u..p.......GsIos.....s.....uN..l.....h.P....c...t...h....t...p...h....h...c...t......h...t.....p.......G...c......h...p...p.....A......t.......pl...p..p...p...l.....h....s....l......h....p...h...l.....h.tt..............ss.s...h.......s........l...K.t...s......h.....p.....h.....h........G...h.......s.s..s....h...R.hP....h.s.s..h.sp..p.p.t.t.tltthht...h...........................................................................................................................................	0	799	1639	2295
+1761	PF01368	DHH		DHH family	Bateman A	anon	Pfam-B_1245 (release 3.0)	Family	It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null --hand HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.21	0.71	-4.55	150	10761	2009-09-12 04:54:29	2003-04-07 12:59:11	15	57	4504	39	2562	8005	1706	162.10	20	32.36	CHANGED	tlppscpl.hlhsch..DsDulsSssslhphlpphsh.pthhhhsspthpt.h...hsttth..............................................................................................................................................................................................................................................t.ttppssLllhlDs.utsshtthpttpth........hpll.llDHH..spp.h................lpsthhs..........hhc.hsuuusuhhlsphl...............................hspphtsllhhGhl	................................................................h...p.ppl..llhGch....D..sDul.sS.s.hs.....h.tp..h..h.....p...p........h........s......t..............p.........s.........h.........h.....h..l..s...p.....p.................s....s......s...................h.sh.h..thtt........................................................................................................................................................................................................................................................................................................................................................................tsslllhVDs...u...t....s.s..p....t...s..s..p...h..t.p..hs...............h.pl.l..llDHH...s.sp.h.....................................ss.hs............hhp..hsuu..usuh.hlh.p....h.l.pt........................t.....p......h.tphhs.llhhGhh................................................................................................................................................................................................	0	921	1749	2205
+1762	PF02833	DHHA2		DHHA2 domain	Bateman A	anon	Bateman A	Family	This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members [1]. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.	21.20	21.20	21.60	21.60	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.58	0.71	-3.94	126	2132	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	1956	28	508	1459	93	128.40	35	33.02	CHANGED	u....h-hhcAtosl.sshosc-llptDhKpFsh.......su....ppluluQlpshshsplhscp..........sclhsthp.phtpcpshDhhllhlT......DIhppsohlLhhu..tptphhppAash.phps.sthhLp..............................GVhSRKKQllP.Lpcsh	.....................s.hpMLKAG.o.sl...ss.+.osc-LlshDhKsFph................su.................ppltluQVsslDl.s-lhp+p...................s-lcsshp.th.s..t....p..puh.......ch.hlLhlT..........................DIls.ss....SclLslG.....tstch.....lpp.AFsh.....pl.....p.....s......sp....s.hLs..............................................................GllSRKKQl.VP.Lpcsh..........................................................................................	0	175	314	423
+1763	PF01180	DHO_dh	DHOdehase; 	Dihydroorotate dehydrogenase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.95	0.70	-5.46	12	6787	2012-10-03 05:58:16	2003-04-07 12:59:11	16	50	4626	118	1697	6540	4232	282.50	29	80.42	CHANGED	hLssplhGlcapNPlh.AuGh.t.GpphsphhsLu.hGhl.ltusThpsp.GNPpPRlhchstu..hlNuhGhsN.GhDhlhpclh.hhpc.....................................lsI.hshstss.....h-DYltsscplu..shschltlNlSsPNs..Ghhshtpss-lst.Lspslpchs..................................................psPlhVKluPsls-.shhslAs.ht.tpsLshls....Tlpt.hlDl+stpslhts...tsGGLSGsslKslAlchl+plhphss..IPIIGsGGIpoucDAlEhhhAGAShlQlhTuh.asGPhlss+IhccL.phL	............................................................................................................................................................................s..tsphhGlphpNPlhh.A..u.G..h.s.p.p.u...p.t.h...t...t....h.....h.......s..h.......u...hGtl...htol.T......c..s....p..........G.........N.......s....p..........P..R......h.......hc.......l........s........p.......s...................................h..l.......N..t.h......G..........h.....s......N.............G......h......-...t.....h..hp...p..l..h.t.h...h...t.p...............................................................................sls.l....l.....u....hstto...............h..-..-...Y..h..ts.h.c.p..lt..............sh..s...s....h...l...plN.l....S.s.P.....N.....s...........u....h.t.....s........l..t..........t...s.....s.....p....l......s....p.h.....l....s.p.h...h....p...p..t.s..................................................phPlhl....K..l..u............P........s..l.s..-.......................s.....h...h.........s......h.....A........s...........t.....h.........h....t..........p......s..........l.s..............s.......l...hh.N.o.T..l......s.t....................s.....l...p.......s....h....t.....s......h......t..................thG.G.....l..S..G....t......s.....l.....p..s.....h.......u.......l.....c.......h.....l......p......p......l......t......p........p.....h..............p..............................t...........l......P.......I.....IGs..G.GIpos..cDA...h...E........h...l...h...............A.G.A.o...hV.Ql.......hT....u.h.h...a....p...G.P..t.....lspclhptL.th..........................................................................	0	544	1054	1421
+1764	PF01761	DHQ_synthase		3-dehydroquinate synthase	Bashton M, Bateman A	anon	Pfam-B_1327 (release 4.2)	Domain	The 3-dehydroquinate synthase EC:4.6.1.3 domain is present in isolation in various bacterial 3-dehydroquinate  synthases and also present as a domain in the pentafunctional AROM polypeptide Swiss:P07547 [2]. 3-dehydroquinate (DHQ) synthase catalyses the formation of  dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate [1]. This reaction is part of the shikimate pathway which is involved  in the biosynthesis of aromatic amino acids.  	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.59	0.70	-5.47	95	4669	2012-10-02 14:41:14	2003-04-07 12:59:11	15	21	4283	45	1160	3985	3068	257.20	42	63.32	CHANGED	hlslssGEptKo.hpsht.plhstLhpts...hsRsssllALGGGVlGDlsGFsAAsahRGlsalQlPTTLLApVDuSVGGKTulNpshGKNhIGuFaQPpsVlhDsshLpTLPtRE..htsGhAElIKauhI.t.D...sshaphLcpp.tt........................ptpsLp......phI.......t+SsplKA.plVspDE+E.sGlRtl.....LNhGHThGHAlEshtsY......phh.HGEAVAlGMlh.s.uclutthGhh.s.tthp............clpplLpphGL.P...s.shsph.................ss.-pllph...httDKKsp	...........................................thhlPsGEptKs.hp.s.h.p..p.lhst...L.l.pps..h.s.R.s.s..s.llALGGGVlGDlsGFsAAoahRGlc.FlQlPTT.L....L..A.p.VD...S.....S.VGGK.Tu.l...N..p......s....h.....G.............K..N...h...lG...A..F...a...Q..P...p..uVlhDhshL.c.TLPtRE.ltuGh.AE....V.I....K....a.....G.l....I...t.D.....ss.......h.ap.hLE..pph.p.t.h.ht..............................stpsht......phI.................t+.u...s...p.l..K..A........cl...V..s.......p...D...E+E........s.......G........l........R...tl................L........N..h.....G............H...T.........hG.H..AIEsth.sY.......tphhHGEAVAhGMlh.A.u.cl.u.pp...h..G..hh..sptpsp....................+lh..plL.p.p.h.G.L..P......s.s.hsp.....................shpphhp.tMtpDKKs.t....................................................................................................................	0	401	765	1004
+1765	PF01487	DHquinase_I		Type I 3-dehydroquinase	Bashton M, Bateman A	anon	Pfam-B_2492 (release 4.0)	Domain	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Type II 3-dehydroquinase catalyses the trans-dehydration of 3-dehydroshikimate see Pfam:PF01220.	20.70	20.70	20.90	21.20	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.32	0.70	-4.70	150	2260	2012-10-03 05:58:16	2003-04-07 12:59:11	10	37	1982	52	564	1429	154	219.00	32	56.47	CHANGED	slslsspshtchhtphpphtt..ss.DhlElRl..Dhlp..................p.ltptlptlppps...shPllhTh..R...................sp........tEGGph.p..hsc....cphhpllcpshchs.......s-alDlElp..hppt.hht......hhhtppsts+lIhSaH.sFppTPshpp...lhp....hhpcht.phGsDlsKlsshspshpDslp.lhphppphp.....thPlIshsMGphGplSRlhsshhGSshoau..thspssAPGQlslpclpphhp	..............................................................lslhspshtph.h.p.p.hpthpph....ss....DllEaRl..Dahtt..................................................shcplhphhtt.l+cth...sphPllaTh..R....................ot........pEGGch...s.....hos.......ctYl....pLh....ctsh....phs..............sD.hIDl..........Ehh...s....t....pc..htt................ltttptpsspllhSpH...sFpcTP.ptcc...............lht...........hlpchp..p.............h.....s.s.D........lsK.lAlMs.ps..p.pDVLs...Lh....photphpp...........sspPl..lshSMuchGhlSRlsuplaGSshTFu.........shpcsSAP.GQlslscl+phh.p.............................................................	0	165	339	475
+1766	PF01220	DHquinase_II		Dehydroquinase class II	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.10	21.10	21.30	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.60	0.71	-4.86	191	2882	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	2604	343	840	2257	2156	139.20	48	92.52	CHANGED	hpILllNGPNLNlLGpREPplYGs.pTLs-lppplpp..tApph..u..lplphhQSNpEGpLlDtIHpA.....tsp..scuIlINPuAaTHTSlAlRD....Altul...sl.P...hlEVHlSNlHuR.EpFRH......+SaluslA.tGlIsGhGspGYplALcshhp	..........................plLllNGPNLNhLGpREPplYGs.tTL.s-lppplpp..t..A..p..p..h......u....l.c.lchhQSNpEGpLlDtIHpA....................tsp..scsIlINPuAaTHTSl...AlRD....Altul...s..l..P...hlEVHlSNlHsR..EsFRH......+SalSshA.tGlI.sGh.GspGYpLALpshh.p.................	1	251	526	715
+1767	PF04706	Dickkopf_N	dickkopf_N; 	Dickkopf N-terminal cysteine-rich region	Mifsud W	anon	Pfam-B_5838 (release 7.5)	Family	Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one [1]. The C-terminal region has been found to share significant sequence similarity to the colipase fold, Pfam:PF01114, Pfam:PF02740 [2].	21.20	21.20	21.20	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.92	0.72	-3.80	13	214	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	54	0	110	172	0	52.00	45	19.55	CHANGED	.ChsD--CssspaCptscpp.......thClsCR+p++RCpRDuMCCsGshClNGlChs	....................Ch.Dc-CssscYCptsp.t...........tChsCRc...p+...c+CpRDu.CCsG...phCssGhCh......	0	11	26	52
+1768	PF05086	Dicty_REP	Dict_REP; 	Dictyostelium (Slime Mold) REP protein	Moxon SJ	anon	Pfam-B_6278 (release 7.7)	Family	This family consists of REP proteins from Dictyostelium (Slime molds). REP protein is likely involved in transcription regulation and control of DNA replication, specifically amplification of plasmid at low copy numbers. The formation of homomultimers may be required for their regulatory activity [1].	20.70	20.70	114.70	114.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	911	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.66	0.70	-13.84	0.70	-6.79	5	10	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	5	0	2	10	0	732.20	36	98.23	CHANGED	scLIPWcsFhhFalpILE-FpPsKRsp..h..ss-IMsahYSs+sLlhKElFRolls+pph.....scphtDsLDlcoIFc+TSLhsh....spsscsDLDDllpI+Ks.psGKIlVoDsDQAIFIIDHFSRluDsQVFsKKsIsGFRslEKhVScsGYKIcDaRphGlcWFsFLNKlRTuCspachF....h.puhaKalDFISMLoslHsItVDcQN+-EEcLSslYoLYPFl-LE..........pp.s.t.pulsocNtpRpshpPsspsNsTTTTTTTTTTTTspshT+KR+thsspsls.s.t.....ps.tsssts.......................tsphpcpsSRKSGuLK-VRlDsIS...................s..hssssspSlsPs-sIlSlSN+IKsCLlEllpSKGEIso-lVKuIFcsLQsKsYosDLlDSIFsQNKSEKVITlSS+lFsluuKlDaDEI+Fu-lS-DlF-LoKRLoFEKNTNILIPTp-tENpFGFLWlPIVNGssSTSIaLSPsN.ScVsas+I+SllKFIQLCIllu-INsFlolRSIoFDsFKSIosELLGMScRlLsLEsDV+KLKDllsKs...KKKspl-ss-hpusssscscFAsaVaEF.INNNhYIKLSKp-NuLKLs-sPsSoLsVEYDPsoI-HKVGFlFHCRSEISKFssstNhaSINsLlpSFTPNNIsslSQ-sENDLKRKYSLMSSDhScllKssssFlPSNFcRFlsITITNsuYNhN+VFuFcDISsGlSITNLRsIasccScp.cNRYcEYlGcTRlIRAFFhAPCLIQITNlsFso-pLpsD+slsRQIKSIKI+NLSYIPIDIKVGGslIDTIKuspTcsVpINSSEFoFSISCLcIoFSooLISKsKLsNLsTlls-.KYscpTslLpssDKhscLs+sFlscapchN.sLTcLEcaLlupF...tuhcD-ccsEcEcp--DEDpDEsEDE	............pcLlsWppahhaahhlLcpatsscR.p.....ss-IhpthaSschllh+ElFRslhsph........t...DhhchpslFsthsh.........sh.hsLcchhphcKs.psuKlhVsDsDQuIhIlDHhSRlsDpplFsKctlsuaRshEKhlopt.YKlpDhRthGlcWashlscl+otCttpphh.......shac.sDhIuhLohlHslhltpQNc-EpplSthYoLaPFhsLE..............pp...t.pshsspptp+ts.pssp.sssTTpoTTTTTTTs.tshpp+pp.ht..p..............................................h..hsoRcoGuLccVRlssIo.........................sssspp.ssppsIhSlSs+IKshllEsh.sKGElshcsVKulFpsLQsKsYshsLl-slFppNKS-+VITlosphaplssplsa-EI+huclop-lhphu+pl.aEKsTNILlPTps.csthuFLWlPIVsshsSTSlaloP.s.opssasplcuhlKFlpLCIslucIstFls.RSIoa-tFKplsp-L.lsMSpRlLsLEtshcpL+phhppp...+p+ht.pps...p..s.ssp-pchhsalpEF.IssshYIKlS+ppN.sLpLs-sPsSoLslEYsPsoI-HKlGFhaHCRSEISKFsssts.hpIsslhpSFTPsNI+NlS.-pEs-LK+KYuLhsS-hopl.cshs.FhPpsFcRahsIohTNssYNhs+VFuFcDISpGhSITNL+sIatcsopp..ppY.-YhGsTRlI+AFFhAPCLIpIsNhtFsssplhsscslsRpIKSlcI+NhSYlsl-IKVssshlsolKuspTpsV.INSsEFsFSISCLchpFSsoLISKs+Lpplpohhsp.+Ysp.ps.h.phhsphscLhcsFlpphp.hN.plopl-phlhp.a....u.tc-cpsEspc.............-...	0	0	2	2
+1769	PF04562	Dicty_spore_N	Dict_spore_N;	Dictyostelium spore coat protein, N terminus	Kerrison ND	anon	DOMO:DM04424;	Family	The Dictyostelium spore coat is a polarised extracellular matrix composed of glycoproteins and cellulose. Four of the major coat glycoproteins exist as a multi-protein complex within the prespore vesicles before secretion.  Of these, SP96 and SP70 are members of this family. The presence of SP96 and SP70 in the complex is necessary for the cellulose binding activity of the complex, which is in turn necessary for normal spore coat assembly [1]. The function of this region of these proteins is not known.	22.30	22.30	27.90	27.30	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.53	0.71	-3.82	9	43	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	4	0	43	47	0	117.80	32	20.62	CHANGED	h-C-s.hsEspCcus.s.ChhLsasuCCGcpphhCscsstNsChssslSCh+sspospIhEhWSsC.hPpc......sFp.a..PsptoCss...hpCpspGhsCcaspsssChsTSCCPchspChstss	.......h.sCEs..hspspCpsshs..Cpals..ahuCCG.cppthCls.ss..........p...s.....sCp......p..s..s..l...sChps..spsspIaEhWS.s...C.pP.pp......Gap.a..P.sstoCsp...LsCpspG.hsCpas.p........sssC...huTS.CC.sthstCss..s...	0	34	43	43
+1770	PF00186	DHFR_1	DiHfolate_red; 	Dihydrofolate reductase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.07	0.71	-4.65	89	5237	2012-10-03 00:23:32	2003-04-07 12:59:11	14	18	4170	438	1010	3895	1205	156.60	33	84.23	CHANGED	hlslIsAhscNtlIGpssplPW+LPsDLpaFKp..hThG+sllMGRKTa-Sl.s....+..PLPsRpNIVlT.Rs.s..hp.....t.s...s...lhpSlppAl......t.ht....ppt......p-la.lIGGuplYpthls..hA-...clhlTclc..tph.p.GDsaFP.pls..spWphspppttt..spp...sshsasFhtapR	.............................................lshI.s.A.h.....s.....p.....s.....t....lI....G......t......p......s......p......lP..W.....+......L.....P......s....D.....h...t....a.F...Kp...............h.T.............h.............s.................p...........s.......l.......lM.GR+TaE.....S.ls................+...PL.Ps.R...pNlVlo+sss................hps.................p..sst............lhp......S..l-.-...ul..............................t..ht......tp.......pcla.lI...........GGup.l.Yp.ph..l..s.........h....sc.............clal....Tc..Ic.............sph....-.....GD...s....a....F.........P....p...h......s............s......p.......ac...s...t...p...p....h............................tp.......sshsapa.hh.+......................................................	0	312	602	830
+1771	PF02966	DIM1		Mitosis protein DIM1	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.64	20	463	2012-10-03 14:45:55	2003-04-07 12:59:11	11	4	318	9	303	648	68	123.00	59	88.41	CHANGED	hLPHLpoGWcVDQAIloEc-RlVVlRFGR-pDstCMphDElLhpluE+l+NFAsIYLVDlD..cVPDFNpMYELh....DPsTlMFFaRNKHMMsDaGTGNNNKlNaslcDKQEhIDIlEslYRGApKGKGLVlSPhDY	......................................hLPHLpsuWpVDQAIlo.E-..-Rl.VV..............IRFG+...Dh.......D.ss........CM.phDElLhpl.....A-.+.....V.KN.F..AVIY..L..V..DIs..cVPD.FNpMYELY....DPsTVMFFaR.NK.HhM.lD.h.GTG..NN.NK.lNW.shcDKQEhIDIlE........TlYRGA.+KG+GLVlSPKDY.....................................	1	94	161	241
+1772	PF05163	DinB		DinB family	Bateman A	anon	COG2318	Family	DNA damage-inducible (din) genes in Bacillus subtilis are coordinately regulated and together compose a global regulatory network that has been termed the SOS-like or SOB regulon. This family includes DinB from B. subtilis [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.82	0.71	-4.55	14	1291	2012-10-02 14:44:17	2003-04-07 12:59:11	7	1	629	11	408	2210	324	161.30	18	97.05	CHANGED	Msppsh.........phhpa.thsssphhchltsLss-phs...tc.spshholtphLsHlhtschhWlsthph...........ttsph.ppsptcshphhcshppshspthhshhpphs-....ttcphh..s.tsstshphshsplLhHlhsHpsHHRGQlsshlRphGhsss.hshhhh...t................t.ch	..........................................................................................................thhpa..th.s.spp...h.h.p.h.hp.p..L....s..p..c.p..hp............pp.h..s.s.h.h.t.oltcshh...H...lh...s.s.....c.h.h...a..l.s.t.hps.....................................tt....s..h........p...t...h...........p.....p.....s...h....p....p.....l...c...p....h....h..p.....t...h......s.....p...p...hp.....p..a..h.s..p..h..sc.............t..t.h.hhh...........pt.s...s..h....t......s..h...p....h.......s.h...t..p.........h....l...t..H...l.h...s....Hps.HHRGQlss.h...lR.p.hG.h.s.s.s.s.hsh...............tt....................................................................................................	0	165	288	348
+1773	PF00775	Dioxygenase_C	Dioxygenase; 	Dioxygenase	Bateman A	anon	Pfam-B_1018 (release 2.1)	Domain	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.26	0.71	-5.03	20	2905	2012-10-02 19:08:27	2003-04-07 12:59:11	16	16	1090	387	1080	2726	434	159.70	27	65.12	CHANGED	l-GPhYlss...APptss.huchs.t..ss.GpslhlpGpVpDtsGcPlsGApVElWHAsscGhYShasss..ts.paNLR..GpllTDs-GpYchpTlhPusYshPspGsstthlp..hGRHshRPAHlHahVoAPGa.cpLsTQlahpGDsalt.sDhshu.....s+spLlhshpptsss...................................hpchpachsLssp	...............................uPha....t..........................................ts.Gp.l...hlp...GpVh...D......t.....s...G...p...P.l.ss....u..hl-lWpA...su.sG..t....Y.s...t........h...........s..............s........s..................................t.......s........c..................s..........h...c.....................G+h..h..T..D..s...s...G..p..a.p.F..p.....TlhPu..sY.....sh..s........................................t.pshRss....H..lHh...l............u...uh....ptLhT....p....hah..........s..-..hh....ss.h.s......hhttLl.......t...........................................h.........t..................................................................................	0	252	577	855
+1774	PF04444	Dioxygenase_N		Catechol dioxygenase N terminus	Kerrison ND	anon	DOMO:DM04160;	Family	This family consists of the N termini of catechol, chlorocatechol or  hydroxyquinol 1,2-dioxygenase proteins.  This region is always found  adjacent to the dioxygenase domain (Pfam:PF00775).	20.90	20.90	20.90	21.60	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.31	0.72	-4.00	19	910	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	500	43	410	899	78	74.30	31	24.82	CHANGED	ssRs+pIspcllpcLacsIc-hclT.-EahsulsaLschGp.....ptEhsLLussLGlEH..shthDstptps.uhpG..GT	........ssRh+plhppLlpcL+shlc-hclT.sEahtulpaLscsGp...................+pEhhLLuDsLGlpp.....hlDthpttt.................................	1	78	193	315
+1775	PF01866	Diphthamide_syn		Putative diphthamide synthesis protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Swiss:Q16439 is a candidate tumour suppressor gene [1]. DPH2 from yeast Swiss:P32461 [2], which confers resistance to diphtheria toxin has been found to be involved in diphthamide synthesis. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in EF2.  The exact function of the members of this family is unknown.	28.70	28.70	29.50	29.10	27.90	28.10	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.11	0.70	-5.18	57	985	2009-01-15 18:05:59	2003-04-07 12:59:11	12	19	467	4	687	991	178	247.50	26	64.82	CHANGED	hPEGLhhhuhpluchL..cp....sst.....sll.GDssYGACsls-hpu.ptlssDhllHaGHosls......ht..h.slal.sph...plDsp.chlcplhpph.......pplullsTlQahptlpplpphLpp.......p...hhlshsps+..htsGpVLGCshssh...........pshlalGsGpFHh.uhhl.u....sph.shthDPa....shshc...p.-tschl+hRhttIp+At..sA..+paGlIluohssQtp.clhcplpphlcp...GhcshllhhsclsPscLtth.s...lDsaVpsACPRlulD.sttFp+Pl.LTPhEhplslstpp.......tpY.hD.h	........................................................hP-tlh..u..lsp.l.....pp..........tt.p.......................hhlhuDs..sY.G.uCClD-hs.A........p........ths.sDhllHa..G+uCL.s........................t.t.l.slalh.sph......t.lc.....ht...thh.p.p.h.pt....t.h......t.t................ppls.lhssh..pa.....t..t...l.pt.h.tt...Ltt...................................t......h.......s......................t..p....l...h...sp...p...............................t.hha.l..us....s..hp......h...............s........hhl.t.....sth.....hh......th....s...Ph...............hp.....h......p....................phtthhthRhth.ltp.........up............p.A..................phhGll.luoLuhps..p.h.hpplp.phl..pt........t...G..h..p............hhlhhucl.s..sKLs.......h.............pl....-saV.luCP..c..h..s....l..........s..............s.....t..F.....+..Pl..loPhEh.lslt.........................................................................................................................................	0	245	397	568
+1776	PF02763	Diphtheria_C		Diphtheria toxin, C domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	N-terminal catalytic (C) domain - blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of EF-2.	25.00	25.00	31.70	106.20	24.10	17.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.23	0.71	-4.85	3	23	2012-10-01 23:25:29	2003-04-07 12:59:11	9	1	10	13	1	35	0	169.70	98	32.48	CHANGED	GADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACA	.GADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKlLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQuCA	0	0	1	1
+1777	PF01324	Diphtheria_R	Diphtheria_tox; 	Diphtheria toxin, R domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	C-terminal receptor binding (R) domain - binds to cell surface receptor, permitting the toxin to enter the cell by receptor  mediated endocytosis.	25.00	25.00	27.80	81.20	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.82	0.71	-4.66	3	23	2009-09-10 22:55:25	2003-04-07 12:59:11	14	1	10	12	1	20	0	138.70	95	26.57	CHANGED	SPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIK	SPGHKTQPFLHDGYAVSWNTVEDSII+TGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGsVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEIsSDSIGVLGYQKTVDHTKVNSKLSLFhElK	0	0	1	1
+1778	PF02764	Diphtheria_T		Diphtheria toxin, T domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	Central domain of diphtheria toxin is the translocation (T) domain.   pH induced conformational change in this domain triggers insertion  into the endosomal membrane and facilitates the transfer of the  catalytic domain into the cytoplasm.	25.00	25.00	28.40	27.40	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-10.95	0.71	-4.50	3	24	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	11	12	1	32	0	178.30	91	28.97	CHANGED	SCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPA	....................................SCINLDWDsIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNsVFAGANYAAWAVNVAQVID.SETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPA.................	0	0	1	1
+1779	PF00200	Disintegrin	disintegrin; 	Disintegrin	Finn RD	anon	Prosite	Domain	\N	19.60	19.60	19.80	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.80	0.72	-11.29	0.72	-3.76	154	2414	2009-09-12 09:20:59	2003-04-07 12:59:11	18	51	294	43	1025	2300	5	73.50	43	11.29	CHANGED	EtGE-CDCGs.cpC..p...ssCC.........sstsC+Lp..sGupC....up.G.CCp..p.Cph..pssGslCRtsp.s-....CDlsEaCsGpSspCPsDhat	.........................EtGE-CD.CG..s.....p.p...C..p........ssCC..................ss..sCp.L...c.........su......u.p......C..............upG.C.C..............c..p..C..p.a......ps.s..Gs.hCRtst...s-.....CDlsEaCsG.p..S..s..pCPssha.h.........................	0	211	280	525
+1780	PF05141	DIT1_PvcA		Pyoverdine/dityrosine biosynthesis protein	Bateman A, Eberhardt R	anon	COG3207	Family	DIT1 is involved in synthesising dityrosine [1]. Dityrosine is a sporulation-specific component of the yeast ascospore wall that is essential for the resistance of the spores to adverse environmental conditions. Pyoverdine biosynthesis protein PvcA is involved in the biosynthesis of pyoverdine, a cyclized isocyano derivative of tyrosine [2,3]. It has a modified Rossmann fold [3].	23.00	23.00	23.70	23.90	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.79	0.70	-5.09	33	360	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	254	4	199	317	7	262.50	32	49.15	CHANGED	plptFlppscPIchlLPAFPsKSP...Np.pKVlGsLPDhuEclALppLsshspcIpplYsPGAclhIsSDG+VFuDlluVsDcslssYspsL+pLhpplu..........hsp.lpahsLpDl........................tth.th.hssphsthRphLhppasssstsl...cpplps...scsththYRGhs+FLh-D....hhs.t.shS+pth+KsspphAhsMIpRupAausLlttpFPptlRLSIHspsssu.KhGIplh...................Pspcsh...hTPWHusssphs....suphhhhp+schtp..shcllphsG	..................................lptalsptp.lchlLPAFPsKSs...N..pKVLGphPDhuEcluLppLsphspcIp.plYs........PGs........p........lhIhSD.G+VFu........Dhl.ul.sDpcl.sYsctL+phhtpht..........hsp.lphhsLpch..........................cphst.h..phstph-thRchLhst.hss.ss....t..l....pppltt...spctthhYpGhp+Fh.pD......h....tt...s.h.S....ppth+.+pspplAhtMlhRu...............pAaushlp......ppFP.ctlRLSIHsp.........sstu.Khulplh..............................sppcsa.....hTPWHssll..s....cGp.hhhhp+pph.p..shp......h...................................................................................	0	23	103	165
+1781	PF04977	DivIC		Septum formation initiator	Bateman A	anon	COG2919	Family	DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation [1]. These proteins are mainly composed of an amino terminal coiled-coil.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.42	0.72	-4.49	70	4922	2012-10-02 13:28:50	2003-04-07 12:59:11	10	6	3891	0	944	2787	1568	78.40	20	63.49	CHANGED	lhshhhhhhhhhttshhshhphcpclsphppphppLppcpppLcsclcpL.p...sp-hlcchARpcLshscssEhhaplspp	..................................hhhhhhhhhhh...h.p...sh.t...ph....h...p.hp....p....p...l...s...p..hpp....php...plp..p...cpppL.......p.......s-lpcL.s..........s.p-...hl.cc.hARpc.huh..s..p..s.s.Ethapl...p....................	0	323	617	794
+1782	PF05103	DivIVA		DivIVA protein	Bateman A	anon	COG3599	Family	The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells [1]. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype [1]. These proteins appear to contain coiled-coils.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.60	0.71	-4.10	99	3249	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1865	6	551	1653	105	105.00	27	54.00	CHANGED	lTPhDIppKcF+psh..R.GYcp-EVDcFLDplhcDYEslh...+EspcLccclppLcpclppapphcpslppsllhApphu-chKtsApccuphllppAptpAppllt...........pu.tph.pltpph-.pLK+pspla+ppap	.................hosh-IhpKpF.p...p.th....R...G..YctcEVDpFLD.pl.......hp-a.......-phh.....................pchc....p.......Lc.........p....cl.....p...pLc.......p.......c.......l.............pp..........h.p.........p....................................t....................................................................................................hh.........s..t......t.t...h.....pup.......tstt...........................................................................................................................	0	199	374	482
+1783	PF00778	DIX	DAX; 	DIX domain	Marcu O, SMART	anon	Alignment kindly provided by SMART	Family	The DIX domain is present in Dishevelled and axin [2]. This domain is involved in homo- and hetero-oligomerisation. It is involved in the homo- oligomerisation of mouse axin Swiss:O35625 [3]. The axin DIX domain also interacts with the dishevelled DIX domain [4].  The DIX domain has also been called the DAX domain.	21.40	21.40	21.80	21.60	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.79	0.72	-4.26	25	558	2009-09-11 10:36:07	2003-04-07 12:59:11	12	24	114	18	287	508	1	77.40	42	11.79	CHANGED	sspTKllYa.lscEpsPYhlplstsst.lTLtcFKshl.s+p..sY+aaFKshDsDFu..sVKEElh-DsshL..PsapG+llua...lhss-	.............................s.tphhVhYa..h.....stE.....hPYhspl.ht.s.....lTLucFKphL...s+p..ssY..+aaFKs.....hss-Fs....sVpEE.lh-Ds.shL..PsapG.+lluhl.p..t.........	0	70	98	185
+1784	PF01738	DLH		Dienelactone hydrolase family	Bateman A	anon	Pfam-B_757 (release 4.2)	Domain	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.57	0.70	-5.06	17	4591	2012-10-03 11:45:05	2003-04-07 12:59:11	13	32	2059	10	1757	12590	4895	210.60	23	80.54	CHANGED	hsualutPsss.....hPslllhp-laGls...s.h+thsppLAptG.ahulsPDlYhRpu........................psschspttphhtthhpph..tplhscl........sslsahcups.hpstclGllG.aChGGthuh.hAups..hlcusluaYG........h..sp..lthssplpsPlhhthGppDphlssps...hpplppshttsssshplchYssAuHuFtsstss...........sasstAupcuWp+hhpahpphh	........................................................................................................................................................................sahs.hPttt......t..hP........u.l.l.....l........l........p............-.......h......a........G.lp..............sth.c...p.....h....u....c....c..l....A......t.......t....G....Y..h..s..l.......s........P..D....h...a.tpps.............................................................t.p..h.s.p.t..t...p..h...h...p...t..h...h..t......p...h.................s...p....h..hs.ch..............................s.s.l...s...h..l...t...p.........p.....s.........................s......s....t.+.....l.uhsG.........a.C...........a.G.........G........p....l.........s.........h.........h.........h............A..............s...............p..................s........s.............p............l..........p..............u..........u.........l.........s.........a....YG......................................................p..t...s...h...t.......s...s..p....l.....p....s........P....l....l.h..h..a.u...t..p...D...s...h...h..s...p.t.............h.t.t....h.c.......p............t..L......p.......t.......s....s.......s....p........h.....p...h..h.....h...Y...s...s....s...s.H......u.F.ss..s..tps.............................................pY.s..tt..u.......u..c...p...u.a.pch.ltahpph.h.......................................................................................................................................	0	494	1027	1453
+1785	PF04914	DltD_C		DltD C-terminal region	Kerrison ND	anon	Pfam-B_6216 (release 7.6)	Family	DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.   It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis [1]. This family consists of the C-terminal region of DltD.	23.80	23.80	23.80	24.10	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.60	0.71	-4.28	36	1136	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	1012	6	85	607	7	128.70	41	31.78	CHANGED	pFGIcsp.aYcp+lKp.plp..+LKspp+phsYhp.SPEasDhQLlLsphscppscVlFlIsPVNuKWhcYTGlspchhpphscKI+hQLpsQGFppIsDhSccuscsYFMpDTIHlGW+GWlthDctlpsFhppp	.....................paGIcst.aYpp.plKp.plp..+h.K...spp.c..p...s.Yhp.SPEYsDL.QLlLsph..pcspscslFlhsPVNs.+.WhDYsGlsc-hhptshcKI+.QlpspGa..pIsDhSccsh-tY...Fh...pDTI.HLGW+...GW.lthDctlp.Fhpp.......................................	0	18	38	63
+1786	PF04918	DltD_M	DltD_central; 	DltD central region	Kerrison ND	anon	Pfam-B_6216 (release 7.6)	Family	DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.   It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis [1]. This family consists of the central region of DltD.	20.70	20.70	20.90	20.90	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.91	0.71	-4.05	9	1116	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	994	6	79	595	1	162.20	33	39.87	CHANGED	lGpsGSsSLsHahshsuhhspLKsKKhlaVlSPQWFstpGlspssFpthhSssQlhpahhpps.ssptcphhAKRLLpFp...scsshpphLcplAsspphsstshh.ltp.tp....hhc+p-ulaSphshs.....s.ppplp+hhKtLPcshSappLsplAscpGp+pTssN	.....................LGpuGopSLsphhshpuh.hspLc..sKKsVallSPQWFo.p.pG.hssssFsthaSppQhhpaltpps.ssphc+hhApR...LLph........cs.t...hKph...Lp.plu...p...s....pphs........p...ts....t...thh....th.tp........hLp+p-....s..hhS.Fshc.......s..ptl.p...+h..h..pt....L...s.cphSapp.lcphApppuctpTssN............................................................................................	0	17	35	57
+1787	PF04915	DltD_N		DltD N-terminal region	Kerrison ND	anon	Pfam-B_6216 (release 7.6)	Family	DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.  It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis [1]. This family consists of the N-terminal region of DltD.	21.20	21.20	23.00	24.50	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.99	0.72	-4.11	32	1047	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	949	6	72	531	0	62.30	44	15.28	CHANGED	cplcpuAsolossshKGphlKpcAl..ppspYlPhaGSSEhsRhDshHPSVhAc+Ypc.sYpPFL	.........shccuAsShotpshK..uphlps+Al..pss+Y..lPhaGSSEhtRhDshHPulhhcKasc.sa+PFL...	0	12	28	50
+1788	PF03474	DMA		DMRTA motif	Ottolenghi C	anon	Ottolenghi C	Motif	This region is found to the C-terminus of the Pfam:PF00751 [1]. DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown.	20.30	20.30	20.30	25.00	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.66	0.72	-4.10	5	284	2012-10-01 23:03:33	2003-04-07 12:59:11	9	4	122	0	123	261	1	38.10	53	10.22	CHANGED	sRoPIDlLt+lFPp+KRoVLELlL+sC+GDllpAIEshL	......RsPlDlLs+lFPsp+RosLEllLptCsGDlVpAIEplL.....	0	28	39	77
+1789	PF00885	DMRL_synthase		6,7-dimethyl-8-ribityllumazine synthase	Bateman A	anon	Pfam-B_1503 (release 3.0)	Domain	This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example Swiss:O28856.	20.60	20.60	21.70	21.20	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.59	0.71	-4.53	104	4443	2009-09-10 17:03:43	2003-04-07 12:59:11	14	14	3970	450	1238	2833	2169	140.60	42	89.31	CHANGED	sssh+lulVsucaNptIscpLlpGAlptlpptG.s..tplslhpVPGAaElPlsspplu.cs.s....c.......aDAllsLG.sVI+GsT.Ha-aVuspsspGlh..pl.....uLcpslPlshGVLTs.csh-QAlcRuuh..ptt...sKGtEAAtAulchlsl...hcpl	.....................u..sh+luIVhuRF..Nph..IsspLLpGAl-sL.p.+.tG...l....p....p....c....sIslshVPGAaElPlsupplA..co..s..........c....................................aDAllsLG.sVIRGsTsHF-YVsspsupGls..pl.....u.l.c.....s.s.l.PV.h.F.G.VLTs.-ohE.Q.A.......lERAGs........KsG.....NKGsEAAhsAlEMhslhct.h....................................	0	390	794	1053
+1790	PF04976	DmsC		DMSO reductase anchor subunit (DmsC)	Bateman A	anon	COG3302	Family	The terminal electron transfer enzyme Me2SO reductase of Escherichia coli is a heterotrimeric enzyme composed of a membrane extrinsic catalytic dimer (DmsAB) and a membrane intrinsic polytopic anchor subunit (DmsC) [1].	19.60	19.60	19.60	19.60	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.70	0.70	-5.14	6	1995	2012-10-01 19:35:38	2003-04-07 12:59:11	7	11	916	0	169	1024	199	261.40	35	93.70	CHANGED	Ms.GhaEhPLVhFTVhuQsslGual...lhullhltucspt..+ph..lltuMFllLsLlGlGFIAShhHLGpPlRAFNuLNRlGuShLSNEIAuGuIFFuluGlaWLlAlltKhssuLuplahllohllGllFsahMspVYp.IcoVPTWaouaTshuFaLThlhuGssLuhuLLpstpls.shshphLshLssLu.................sslsusVslhQGhsLpoIcoSsQpAssLVP-a.........AsLpshRhlLLslshshLlhshhhhc.sslslL.lluhlLlLAGEhIGR...........sLFYGL	....................................................hHEhPLllFTVhuQsslGuhl......V.h..u...l..u..h...h.........t.u..ph.....p.....s.p...................ppt.........lht....s.h.h.h.lh.l..L....h.u..l.....Ghl.AShhHLGpP.......hR..AaNuL..s....+.l.G.uS.hLSNEI....s....u.....u...ol......F......a.A....l.u....Gl....h......a..........L...l..s.........h...........l.......t.....+....h.......s.....s....u....l..t.....p...l.......h.h..l....l.......s.hl...lG...l.l....F...V.a....hMs...pVYp....l.s.TVPTWtss.aTs...hsFa.....lT.....s.h.....l..s...G..s..l...L.u...h.......h......L....l......t.h......u.t.l.......shs....h..p..h...h..s.h.l.s.s.LA..................................lls.ssh..h..........h...h.....p.u....h.p.....l...s...s.....l..c....o....u.l..p...t.u..s.t..L.h..s..s.a.........................................u.tl...sh+...l...l.....L.....l...s..s..uh..s....h...h....l....s..s.......h....t.......t...h...........p.......s....t.......s.s..hL........h...u..h....l.Lllu..GEhlGR...........hlFYs.................................................................................................................................	2	45	97	139
+1791	PF03989	DNA_gyraseA_C		DNA gyrase C-terminal domain, beta-propeller	Yeats C	anon	Yeats C	Repeat	This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a  beta-propeller structure [1]. This region has been shown to bind DNA non-specifically and may stabilise the DNA-topoisomerase complex [2].	20.40	4.10	20.40	4.70	20.30	-999999.99	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.96	0.72	-4.66	362	37895	2009-01-15 18:05:59	2003-04-07 12:59:11	8	34	4630	51	7547	27731	14770	47.70	22	27.63	CHANGED	cp..llhhTppGhsh+hsh................................................schpt..hsRsspGlpsh........plpcs..-plhshhhss	...................................................................................llhhTppG.h.sh..R.h..sh..............................................................................................................schpt.....hs.R.s.sp.G...l.psh...............plp..cs.....-plhsh....t.............................................................	0	2464	4959	6375
+1792	PF00204	DNA_gyraseB	DNA_topoisoII; 	DNA gyrase B	Finn RD, Griffiths-Jones SR	anon	SCOP	Domain	This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold.  This family is structurally related to PF01119.	20.70	20.70	20.70	20.70	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.15	0.71	-5.05	99	18153	2009-01-15 18:05:59	2003-04-07 12:59:11	20	41	10023	20	2024	14069	4290	160.20	42	30.69	CHANGED	Glpcalchhsps.........................h.hpstt..............ps....hpl-lAhtas.s..s.s...c.plhSFs..NsIsThcGGTHlsGhcsuls+slspascpp.phh......ppt.t....plsscDl+cGLssll.sl....+lssP..pF-GQTKp+Lssspsp..shlpph..lp-pht.phlp..css....phscpllppshtttc....sRhs..s+ps+ch	................................................................................GlpsFVcaLNps....K...psl.............hsp..........lhhhps-p..................................cs........lsVElA.hQWN..-....uap.......E..slhsFs...NNIsp+-GGTHlsG.FR..sALT.......Rs.lNs.Yhc...cp...shh...............Kc...t.c......sloG.-DhRE.G.LsAVl.SV....K.ls-P......pFp.uQ.........TK.sKLssoEs+.................shVp.p.h.hs-...tls.paL.....cNP................p..A+hllpKhlpAAp...........AR.A....A++AR-........................................................	0	674	1283	1691
+1793	PF00986	DNA_gyraseB_C		DNA gyrase B subunit, carboxyl terminus	Finn RD, Bateman A	anon	Pfam-B_332 (release 3.0)	Family	The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B  protein is thought to catalyse the ATP-dependent super-coiling of  DNA. See Pfam:PF00204. The carboxyl-terminal end supports the  complexation with the DNA gyrase A protein and the ATP-independent  relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase, [1].	21.10	21.10	21.10	22.00	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.08	0.72	-4.22	72	9044	2009-01-15 18:05:59	2003-04-07 12:59:11	16	17	5005	38	1681	6230	3303	62.90	53	9.63	CHANGED	ttppphpIQRaKGLGEMsscQLWETTMsPcsRpLlpVplc..D....ttp..scchhshLMGc.cspsR+paIp	................s..ppthslQRYKGLGEMNs-QLWETTM.......cPcsR..pLlpVs..l..-....D....................uhp........A-ph..hshLMG-.cVEsRRpFIp.........	0	548	1095	1410
+1794	PF03603	DNA_III_psi		DNA polymerase III psi subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.20	20.20	20.30	20.80	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.70	0.71	-4.28	26	745	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	743	5	76	295	13	127.30	54	93.11	CHANGED	M.s+RDhhLQphGIoQWpL++PphLp..G..phslsLsscsRLllVusphPptsps.LlpDlL+SlpLs.sQshplss-plshLstpph.phhWhlGscpsth.htu...........tpL........pSPtLspLpssspsKRsLWQQIssa	............MTSRRDW.LQQLGITQWsLRRP...u.ALQG.............EIAIul.PsHVRLlhVAs-LP.uLs-P..LlpDVLRALsloPD..QVLpLTPE+lAML..Pp..so+..CNSW.RLGsD....pPLs....LcG...........AQl..............sSPAL.s-LcuNssARtALWQQICsa........	0	6	25	53
+1795	PF01653	DNA_ligase_aden	DNA_ligase_N; 	NAD-dependent DNA ligase adenylation domain	Bateman A	anon	Pfam-B_1334 (release 4.1)	Domain	DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor [1]. This domain is the catalytic adenylation domain.  The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism [1].	19.00	19.00	19.00	19.00	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.85	0.70	-5.48	15	5286	2012-10-02 00:43:09	2003-04-07 12:59:11	13	57	4462	24	1089	4137	3767	299.60	38	46.15	CHANGED	ppsppclpcLpchl+pasYcYYVhDsPhlsDu-YDpLhpcLppLEpcaPELlTPDSPTQ+VGuussputFpplpH.sPMLSLDNAFspc-LpsahcR....lpcthsppsp....aslE.KIDGluluLhYcsGlLs+AsTRGDGphGEDVTpNl+TI+sIPlplshs.......tplElRGEVahsKcsFtpLNpph.cpsccsFANPRNAAAGSLRQLDPclTA+RsLphhsYulu..ps.phshpTQhtsLphL+phGFs.Vspphphsc...sh--VlsahcpapccRcsLsa-IDGlVlKlsplshQccLGaTu+uPRWAlAYKFPAc	...........................................................................t...ppchpcLppplppash.tYY..s...D....s....P..plsDuEYD.pL.h.c.cLtpLEppa....P.......-....h................h.s.......s.D.....S............P....T.p...RVGh...s.....s.l...........p.u.........F.......pplpHthPML..SL..s..s.....s......F..........s..........c.............c.........-..l..p..sF.pR......................lp...c........t...l..........s......p......s....p.............ahsE.KlDGLAloL..hY....c.....s......G.......h.............Llpus.TRG.D.G.p.tGEDlT...p..N.l.........+T..I......c..s....I.Ph.pLptt................................PtplEVRGElahs+psFtpl.N..............tpt.t......p...............p......G............p..........p...............h.....F......A.NPRNAAAGSL..RQ.....L..............D...s......p........l.........o.........A..........p...........R.........s........LshFsYu.....l..............u..................................p...................s...........................................t........................s......o..............p...pt....Lp.hL..p.p.......hGF.........s.s....s....s.t....h....p....h....s.p......................s..h..--.....l..h.p.....ah....pch..............t........p......p...........R......s...........s..L.......sa-I..DGlVlK.VsclshQc.pLG..a........s........u.+.....u.PRWAlAaKFPAp.....................................................................................	0	368	717	925
+1796	PF03120	DNA_ligase_OB		NAD-dependent DNA ligase OB-fold domain	Bateman A	anon	Pfam-B_1334 (release 4.1)	Domain	DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor [1]. This family is a small domain found after the adenylation domain Pfam:PF01653 in NAD dependent ligases [1]. OB-fold domains generally are involved in nucleic acid binding. 	25.00	25.00	27.00	25.40	24.30	23.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.55	0.72	-4.32	23	5111	2012-10-03 20:18:02	2003-04-07 12:59:11	11	59	4425	11	1047	3928	2199	82.00	46	12.29	CHANGED	s.TpLhDlplpVGRTGs.lTPlApL-PVpluGosVopATLHNtDhIcc+DIRIGDpVllcKAG-VIPcllpVlh..-pRssssps	............t.hTplpslchpV.GRTGs.lTPVApL.............c......P.......Vpl.....uGssV....opATLHNhDp.I...........c............c............h...........Dl.+..l......G.DpVl.lp+AGDlIPcllpVlh..pcRstpt.............	0	351	681	885
+1797	PF03119	DNA_ligase_ZBD		NAD-dependent DNA ligase C4 zinc finger domain	Bateman A	anon	Pfam-B_1334 (release 4.1)	Domain	DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor [1]. This family is a small zinc binding motif that is presumably DNA binding [1]. IT is found only in NAD dependent DNA ligases [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.44	0.72	-4.24	152	3952	2009-01-15 18:05:59	2003-04-07 12:59:11	11	37	3909	5	869	3009	904	27.80	47	4.05	CHANGED	pCPsCsotlh.+.ps.....Es.shRCsNs..sCPA	...pCPsCGSclh.+hEG............Es.shRCsss..hCsA..	0	296	579	741
+1798	PF00145	DNA_methylase		C-5 cytosine-specific DNA methylase	Sonnhammer ELL	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.04	0.70	-5.32	31	7421	2012-10-10 17:06:42	2003-04-07 12:59:11	12	102	3000	52	1976	6841	2919	257.40	19	65.39	CHANGED	hchl-LFAGlGGhcLGhcpsu...........hpslhusEhDcp.....AhcoYptNa......phshsDIsphshp....plP.....hDlLluGhPCQsFShAGp....ppGhsDsRG...sLFa-hhRllcppc....PKhFlhENV+sLlspcpt...pshpsllpphcchG..YpVp.......hplLsApDaG.lPQsRcRlallGhcpch.........................th.phphsp.....................h.sltDlhpp.........h.pschshssphhpshphht....t..tsas..........hhhpp........................................cphttsthhshshpppsh..................................h.tsshhtpsst.......................................pthRplTsREsA.RlQGFP-s.....Fphhssps........ptY+phGNuVsVsllptlucplhp	...................................................................................................................................................................................................................................hphFsG.h..G....uh.p.h....u....hpt.hs................................hph..h.h..h.-..h...p.................................sh.t.s...ht...h...ph...................................t..D......l...t...ht.t..........................................th.....t.....h-....l.l.h.u..G.PC.Qsa...S....h....h....s...............................t...t....s......h........t.......p....t..p.s.......................tL....h..h...p..h.h....c....h....l.....p...........h...p...................P.t......h....h.h.h.E..NV.....s......h...........h.............p...................................................h..t....h...h...t.....h...............t..........t..............h...s.........Y.t.h....................................h..l..p...s.t.....p..a.......t......hs...ptRpRh...h...hl...uh.....t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................R...ho..hE...........hh.hh...s...h...t............................a..........h........................................h..hGsuhs..h...hh.....h...........................................................................................................................................................................................................................	0	634	1210	1611
+1799	PF01119	DNA_mis_repair		DNA mismatch repair protein, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	SCOP	Family	This family represents the C-terminal domain of the  mutL/hexB/PMS1 family.  This domain has a ribosomal S5  domain 2-like fold.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.26	0.71	-4.64	151	4737	2012-10-03 01:04:38	2003-04-07 12:59:11	14	30	3934	16	1407	3880	762	118.40	30	17.88	CHANGED	ltsl..hGpshspph.l.lp.tpsps........hplpGalupP.s.....hsRus.psh.hhalNGRhl+sp.....hlpcAlcpAYp.....shLsts+aPhshLhlclsPptVDVNVHPsKpEVRFpcpctlhchlhpulppsLt	..................................................................tslhGhth.h.pph..ltlc...hppts...................hplpGalu.p..P..p.............................hs.Rus....ps..hphhal..N........G...........Rh..l.+.s.p.............hls+....A....l.p...p....uYp.............................sh...L...s....t.s......p..........a..........Phhl..L.hlc......l.D..P.p.t.VDVNVHPs.KpEVRFpppc..tlhphlhpulppsL.t.........................................................	0	473	844	1161
+1800	PF02499	DNA_pack_C		Probable DNA packing protein, C-terminus	Mian N, Bateman A	anon	Pfam-B_1283 (release 5.4)	Family	This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is found at the C-terminus of the protein.	19.60	19.60	19.90	19.60	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.31	0.70	-5.71	27	252	2012-10-05 12:31:08	2003-04-07 12:59:11	10	4	127	9	1	214	0	256.60	42	58.45	CHANGED	LsQsssKIIFlSSoNoucpSTSFLaNL+sus-chLNVVoYVC--HhpchstpsssTuCsCYhLpKPsFIThDsslRpTAsLFLtsuFhpElhGs...tssst.sssptllo-pAhspF.lhRsSTssppsh..LspsLaVYlDPAaTsNscASGTGlAsluph...psphllhGlEHFFL+sLTGouutpIApCssphltulhsLHP.hhppV+lAVEGNSSQDSAVAIAshlpc.h.............shslhFaHstsp..sssltaPaYLLs+pKohAFEhFIttFNSGplhASQ-lVSpTl+LohDPV-YLlcQl+Nlpplshps....sstoYouK..p.pshSDDlLVAllMAhYlus...ssptsF+sl	......................................h.QtssKlIFlSSsNoucpoTSF..LhpL+sAs.p..c.hLNVV..oY..VC--Hhpchst..+ssu..suCsCYpLaKPsFIoh-ssl+cTANhF.l..tsuFhpEIhGs....sspt...s..........psp.llocsuhpcF............lhR.STsspp..sh..hutsLaVYlDPAaTsNt.pA.......SG....TGluhlsth........p.llhuh-ch.ltth.t.s....t.hh...h......a.....h.....h.h....p................................................................................................................................................................................................................................	1	1	1	1
+1801	PF02500	DNA_pack_N		Probable DNA packing protein, N-terminus 	Mian N, Bateman A	anon	Pfam-B_1179 (release 5.4)	Family	This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is normally found at the N-terminus of the protein.	20.30	20.30	22.70	24.70	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.85	0.70	-4.87	26	149	2012-10-05 12:31:08	2003-04-07 12:59:11	10	3	92	0	1	142	0	267.60	39	43.48	CHANGED	R.cphshPhlGslHusspaushhpshspphh.........t.t...s.........ptt....sspshlss........pLpsslppLpFhphs.tpstspcstYpushsoapuhhpsssFppLpsFltshuphLsssapst.................................pupLE.FQK.llMHshYFlsSlphs-psc+h.hshl+hhFslsphossslcpFKQ+AoVFLVPRRHGKTWhlVslIulLLuohcsI+IGYsAH.++sopsVFpEIhspLp+WFsscpl-hhKsp.TIsFsasstppSTlhFASsaNTN.SIRG	.........................................................cRaQhshPtlGhlHsss-hs..htuhspchh............................s..tppp.hlts........pLppslppLpFt..s..psttp+ssYpsshsshpshhcsstFpQlssFlpcFsphLssuFpst............................tctc............................................................pspLE.FQK.lLhHsha.Fluu.spls-hA.p+l.hpaLptsFslshhS....pssl....c....pFKQ+ATVFLVPRRHGKTWFlVPlIuhlLss..h..pGIpIGYsAH.++sopsVFcElctpl++hFssphVscsKsp.sIohsasstu+SThlFASsaNTN.uIRG.....................	0	1	1	1
+1802	PF00712	DNA_pol3_beta		DNA polymerase III beta subunit, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_631 (release 2.1)	Domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.27	0.71	-10.21	0.71	-4.21	15	4817	2012-10-02 11:47:48	2003-04-07 12:59:11	14	8	4456	54	1006	4270	2846	120.10	28	32.57	CHANGED	MKFsIpR-pLlcsLppVu+slssRsolPlLuslLLpsp-..spLolTuoDhElphpuplstpps.......ppsGslslsuRhlhDIsRsLPs.pplplphss..s+hhlp.uGp.......S+FsLsTLsu--aP..sLs	...................................M+Fsl.p.+stLlp...sLpplppsl...s.s..+....s.o..l....P.I.Lu.slhlp....s..p..s........sp.lsLouoD.h......-...l.p..l..p..s..p..l..s..h..p..ts........................psG...s.....h..s....l.sA+...hhh-...Il+...p..L....P.....c.......t..p...l.s..l...p..h..c..s........pp..h..h.lp..uG+....................Sc..FsL.ss.l.s..us-aP.pl............................................	0	348	678	861
+1803	PF02767	DNA_pol3_beta_2		DNA polymerase III beta subunit, central domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_631 (release 2.1)	Domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.22	0.71	-4.06	15	4914	2012-10-02 11:47:48	2003-04-07 12:59:11	11	14	4454	54	1035	3844	2795	115.90	30	31.47	CHANGED	slssssL+clIppTtFAhupp-sR.hLsGlplchpss....pLhhsATDuHRLAlpchphspstss..hsVIVPsKslhELs+llss...sp.lpltlu.......ssplthcssshhhTS+LlDGcaPD	............................lstphL+chI.p.p.T..t.FA...h..u...p.p...-..s.R......h.LsG.....lhh...c...l....p...ss..........pL.p.sVA..TD......u.....H....RL.A.........h........p.p............h.............p............l.............p.....p............s.........h......s.......................p...............h......slIl.P...t.KultE...lt..+.l.l..ss.......sp..p..s..l.p.l.t.lu..................s.s..p...l.h.h........p..........s...........s....s...........h....h....h.h.S.+.L..l.-.G.p.aPD..................................................................	0	353	699	887
+1804	PF02768	DNA_pol3_beta_3		DNA polymerase III beta subunit, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_631 (release 2.1)	Domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.	20.30	20.30	20.40	20.30	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.23	0.71	-4.54	16	4819	2012-10-02 11:47:48	2003-04-07 12:59:11	10	13	4457	54	1006	3167	2433	121.10	27	32.84	CHANGED	ppllPpchsphlslssp.LtcAlpRsulLup.-+spsl+Lpls..sspLclsusssEhGpucE..tlcsshh..GcslpIuFNspYLLDsLsslcspclplphsssspshllpsssssssp.llhPh+	......................................+llPp.s....s..p..plp.h.spppLhpAlcR.su.ll.....op....p...+..t......p..s...V...+L..p.l.s........p.s.pl.....p...l....ou.s....s....s.-.......u........c.u.pE.............pl...s.s......shs..........G.c.....s...l.c...I...u..F..Ns..pY..llD...sLps..l.....c...s.-...p.....l.plp.......h.......s.s.......s.........s......ps...s......l......l......p........s......s......s......s......p......s.....h...h...h..l..lhPhp......................................	0	348	678	861
+1805	PF04364	DNA_pol3_chi		DNA polymerase III chi subunit, HolC	Kerrison ND	anon	COG2927	Family	The DNA polymerase III holoenzyme (EC:2.7.7.7) is the polymerase responsible for the replication of the Escherichia coli chromosome.  The holoenzyme is composed of the DNA polymerase III core, the sliding clamp, and the DnaX clamp loading complex. The DnaX complex contains either either the tau or gamma product of gene dnax, complexed to delta.delta' and to chi psi. Chi forms a 1:1 heterodimer with psi.\	The chi psi complex functions by increasing the affinity of tau and gamma for delta.delta' allowing a functional clamp-loading complex to form at physiological subunit concentrations.  Psi is responsible for the interaction with DnaX (gamma/tau), but psi is insoluble unless it is in a complex with chi [1].	21.40	21.40	22.40	22.30	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.78	0.71	-4.34	151	1629	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1600	3	343	975	388	138.40	35	93.69	CHANGED	M..sclhFYhLspssh..........tphhspLhpKuhppGh+.lhltspsppptptLDchLWsass-uFlPHsh..ssps...sst...p.PlhLsh.stt..sss..ts..lLlsL.sssh..Ps.hspF.pRll-lhsss-s.thptARp+a+ta+.st...Ghslph	.........................MppssFYlLssssh.......................pphlCcLst...ctac.p..G.....p.....R.VlltspDc.ppAtpLD-tLWsh.ss-uFlPHsl.....sG..Eu........sp..ss................s....PV.luhspp....t...........sss.+s..........lLI..sL.pssh........ssh....s..ssF..scVl-hVsh--s.h+phA.R-RaKtYR.st....GasLsh.............................	0	79	183	259
+1807	PF00476	DNA_pol_A		DNA polymerase family A	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	\N	23.80	23.80	23.90	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.15	0.70	-5.84	12	6834	2009-01-15 18:05:59	2003-04-07 12:59:11	15	51	4984	160	1526	5654	5505	340.20	33	42.62	CHANGED	lchchhpthspchshp.htthttphhchuGppFNlsSscQLphlLF-chGl..hthTcp..Gs.oTssssL-pLt...sc.hlphllpa....Rpls+LpsTalctL.phlsstsG+lHTpaspssTtTGRLSSssPNLQsIPh+s......c.GpcIRpuFlAp.G..hslluuDYSQlELRlhAclusDpthlpsFppGtDlHphsAuchaGlshcs....VsuppR+sAKshNFGllYGhSAhtLuppLs.....IopcEApchh-tYFtpaPG..................................lcpahcchhc...........cu+ppGYlpTLhsRRc......lPclsSp....stshcptAERh......AlNhPlQGoAADlhKhAhIplc.hLpc.t.ps......RhhlpVHDEllh-ssp--..httlsthlpplMcpshth........pVPLhs-hshG.tsWhsA	.......................................................................................................................................................h.....h.t.ttpht.t..h....tth.ttp....h.h.t....h..s...G..p..t.F.N.l.s...SsK.Ql.t....l.....L..F..c..c.......h....t..l......................................h......t......p......p........p...................t....................o......T..s.....t....pl.....L..p......pL....t..........................t..........h.....s......l..........t.hlLpa........................Rtl.s.K...L..p.o....T............a....s....c..t....L.....................t......h......l....p........................p..............s.......u............R...l.H...o.p.....a..............Q............s...........h.........s.t.TGR.L.S.S...s.s....PN.....LQ..N..IP..h+s.................................p.G+.....c....I.....RpuF...l.....s........s.........pG...........hhl..l..u..ADYSQIELR.lhA....H.....l....op..D.p........t.......l.......l...p..........A.......F.......p........p............G...........t.......D...........l...H..p..tT..A.....uc.l..F..s....l.s.h..cp...............................ls..s...p.p....R+.p.A.Ks.lN..FGl.......l...Y..Gh..o..sa......uL......u..p......p..Ls...............................................ls.c..p.-.....A....p....p.....hhc....pYappaPu.......................................................................................lppa..h..cp.h.hp...........................................pA.c..p...p..G..Yl..p........T.....lh..s.RRt.....................................hl.....P.c..l..p.up......................sh..h+t..h..u.E..Rt................................................AlNsPlQ.G.oAA.DIl.......KhA.M...lp...l...p.p..h.l......p..p.....t...t....h..ps....................................+..hlh....Q...VHDELlhEl....p....pc....hpth.....tt..h.l...t..p...hM....p.p.....s....h.p.h.................................pVP..Lh...sc.h.t..G.tsW.p............................................................................................................................	0	539	976	1295
+1809	PF03175	DNA_pol_B_2		DNA polymerase type B, organellar and viral	Mifsud W	anon	Pfam-B_236 (release 6.5)	Family	Like Pfam:PF00136, members of this family are also DNA polymerase type B proteins. Those included here are found in plant and fungal mitochondria, and in viruses.	22.90	22.90	22.90	22.90	22.80	22.70	hmmbuild  -o /dev/null HMM SEED	459	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.55	0.70	-5.82	35	975	2012-10-02 01:06:00	2003-04-07 12:59:11	8	18	262	25	572	970	44	307.10	22	53.07	CHANGED	chs.....cshhhhstplhh.DhsFhLsphppht..............hhphthhppshhpphchphphhphhltDoatlhh.sSLccsupuasl............hpKGhhPYctlsp.h....h.....ttshPhhcYhcc.phhhhpcplhp.hc...s.taclhccslcYsphDlhlht....plhtpapphlpcphsl.psshphap...luu.ohtIF+phh...............................................................phsstlhsPs.cchaphlRpulhGGRs.sph.shhp.....lahYDlsShYPuAhp.ashPhGpPhtstt.pththpch.htlpp....lphhspphpshl.....hlsh+sssphh.....hsshsshsu.....hhaosE-Lchtlspu......hhcshhlcsh..ccpsslFs-ah...ccahplphsucppuccpp......luKlL.N.uLYG+Fupp.....spchhlhs-ph........-ptphppltssphhlpppthhps.......pshssphh.tsstshshtp..htphspsttst.pphthtsttsh	...........................................................................................................................................................................................................................................h.hp.h.hh....l..h...h...t.................................h.h........................................................................................................................................ta..ch.c....t.h.....YCt.DVhlht...............chh.p.a..tp..hh..pthp...l....th..h........lsS.u...t..lFcphh....................................................................................................................................................s.t.lht.s...pp.hp.....a...l....p..p...sl.GGR...s..........................h.....h.....p.......p.lh...aDh..s..uh...Ys..SA.ls...h..h....G..Phs.h........................t..........................hh.......................h.h................h...........................................................h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	439	448	571
+1810	PF04042	DNA_pol_E_B		DNA polymerase alpha/epsilon subunit B	Wood V, Finn RD, Bateman A	anon	Pfam-B_12632 (release 7.3) and Pfam-B_5821 (release 7.3)	Family	This family contains a number of DNA polymerase subunits.\	     The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner.  DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast.  The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18.  Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure [1].	20.50	20.50	20.70	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.41	0.70	-5.08	34	1130	2012-10-02 19:15:56	2003-04-07 12:59:11	11	22	407	8	787	1175	118	215.10	19	39.82	CHANGED	llhsSGlhhs...tsshs....hchLpchlptht..........ss.sstlllhGshlstptt.ht.t.......................shstshhhltplpshlppls....tssplsllPuspDssst........hLPQtPh.pt.hhsc.pth............................hphsoNPsphpls..shplsssss-hltclt+tphtpss............................................................................hchlcplLpppplsPhsP..................................shhshsatpppshhl.ps..hPclhlsus...ttpFsp	.................................................................................hhlhSslhhs......s.shs...............hphLt...chl.ptht........................ssts.s..h.lll.hGs.hlsts..t..h.h.tttth............................................sh.p...p...h....th....h....t......p....l.ts.h...h.tplh............tshp.llllP.G.s.pD....ssst..........shP...Q.s..l.pt....hh.s.ph.pph..................................................hphsoNPsphpls...................sh.pl...hhsp...schlpclt.+.t..p..h.t.t.s.t..................................................................................................................................p...tc.l.h.cplLpppphsPhhs...........................................................................sh.h.sh..sa...p....h...p...s..s...h...hl....s..........hP...clhhhss......F..............................................................	0	269	448	662
+1811	PF04931	DNA_pol_phi	DNA_pol_V; 	DNA polymerase phi	Wood V, Bateman A	anon	Pfam-B_10566 (release 7.6)	Family	This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localised exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.	22.00	22.00	22.20	22.00	21.30	21.90	hmmbuild  -o /dev/null HMM SEED	784	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.21	0.70	-6.76	5	422	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	249	0	305	433	5	450.40	15	60.45	CHANGED	huYlLcRLI+GLuSsRpuARssauluLsplLstsp-IsssclL-tLc+csshsusp+uh-cssla.h...usLlsshsullhupll+cKsplsEslFppltlLhlhpuptsaLpusslplIsctLccsshpp.sh.sLhshlsKlLps.hcVs.oS-clLula.Lshs+VhsNccSp..sVthhsp-shcsLhclh.lsusolppcpscsclAusLlpLsKs..Klsusap.lspcthhKpsutcusshssphlslssslhssEphthlcpsspppptlp+sssS+spsshcFhcphppslspthpsEccsspRhhhphhshltsscppssshsshsphhplhppLsopshss.loss+cspplh.pssVcoltchsshppshlpssstplscuolss-ppp+htpsphlhllcpthppKptshlcph..FplapsactsKssTst..AlsstFS...EsssptlclsthsuLhhspSsthpQs.s.tp.GchtLspLtplsphpLp+pLscsstpup.csshscppppsasplcppL+pcsupsu-spspAFcpLlllVsLplhspss-S........s-VLpDlpsChcKuhscssp....tp.+EpsscEPssM-VLTElLLSLLuQsSsLhRclVchVFspFsp-lsp-uLpllL-VLKtc.shscpsth.tGEEE.EDsh..oDsDED-pcsl-DuEsESE-........DsEssEsDEp-DDuEusptlh.hc.ulcppLscsLp.sssl.................cGu-S-DEEsMDDEpMhcLDspLA...plF+E+Kc...+hQuscEcKppsQps+ppllpFKlRVLDLLElYl	.................................................................................................................................................................................................................t........h..........l..hh...............h...............................................................h.......t.........h....t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..............................................................................................................................t.....t................hhh-hhlthh.p......t.....t.....h+t....hh...h.......................ht.tth..hht........h.........................t......................................................t................................................t.........p...............t....t............................p.......t..t....t.....t.t.t............................t........t.t....t................t.....t....................................................................................................................t.t......p.............t.......h.s...-tt......h.t..h...s..l....thh..............................................p.+hhthh........................................................................................................................................................................................................................	0	105	176	258
+1812	PF00336	DNA_pol_viral_C		DNA polymerase (viral) C-terminal domain	Finn RD	anon	Pfam-B_107 (release 1.0)	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.66	0.70	-5.11	3	8753	2009-09-12 08:13:51	2003-04-07 12:59:11	13	16	93	0	1	8052	1	158.20	90	27.33	CHANGED	GSYGSLPQDHIlcKIucCFRKLPVNRPIDWKVCQRIVGLLGFVAPFTQCGYAALMPLYsCIQS+QAFTFSLlYKoFLpcQYhcLYPVARQRuGlCQVFADATPTGWGLVhGsQRMRGTFuuPLPIHTAELLAACFARCWSGA+LLGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGpLGLLRPLPRLhFRPSTGRTSLYAsSPPVPsHRPsRVtFASPLQss-AWRPP	.........GSWGTLPQEHIVQKIKpCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQuKQAFTFSPTYKAFLsKQYLNLYPV.A...RQ.................................................................................................................................................................................................	0	0	0	1
+1813	PF00242	DNA_pol_viral_N		DNA polymerase (viral) N-terminal domain	Finn RD	anon	Pfam-B_107 (release 1.0)	Family	\N	29.90	29.90	30.00	30.80	29.00	29.80	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.30	0.70	-5.43	15	5612	2009-01-15 18:05:59	2003-04-07 12:59:11	12	21	92	0	0	5444	0	301.90	78	41.87	CHANGED	MPL..............SYpHFR+LLL.....L-E..Eu.....GPLE-tLPRLADEsLN+RV.........AEsLNLth.sVsIPWTHKVGsFTGLYSopsssFNPcWpTPsFPcIHL+pDlIs+CppasGPLTlNEKRRLKLlhPARFaPpuTKYhPL-KGIKPaYP-aVlsHYFpTpHYLHTLWcAGILYKREoo+SASFpGoPYSWEQc..LQHGs..h.pt..t.t.cshsuQSutILuRu..........................ssGsshQuphppSRLGhpup...pGplApuppGpShulRuRs+uospRshusEsSuSspssppA.ScSuSshpQSusRcsAaophSTocRpSSS....upul-hpslPssospupspuslh.ChWhpFRsS.+PCSsYCLsHlVsLL-DWGPC	.......................MPLSYQHFR+LLL.....LD-EA.....GPLEEELPRLADEsLNRRV.........AEDLNLG.NLNV.SIPWTHKVGNFTGLYSSTVPlFNPcWpTPSFPpIHLppDIIs+CpQaVGPLTVNEKRRLKLIMPARFYPshTKYLPLDKGIKPYYPEpsVNHYFpTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQE...LQHGp..h.psspR+G-ESFssQSSGILSRu.................................sVGss...lpSph+pSRLGLQsp...QGpLAptppGRSGSIRARlH..PosRRsFGV.EPSGSGHhsNpA.SsSSSCLHQSAV.RKsAYS.pl.ST.SK+p..S..SS....GHAVE.LHslPPsSARSQSpGPVhSCWWLQFRNS.KPCS-YCLoHIVNLLEDWGPC................................	0	0	0	0
+1814	PF04104	DNA_primase_lrg		Eukaryotic and archaeal DNA primase, large subunit	Kerrison ND, Finn RD	anon	COG2219	Family	DNA primase is the polymerase that synthesises small RNA primers for the Okazaki fragments made during discontinuous DNA replication.  DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae) [1].  The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase [4].	21.10	21.10	21.60	22.60	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.94	0.70	-5.12	48	540	2012-10-01 20:20:07	2003-04-07 12:59:11	9	10	444	11	383	545	79	237.20	27	54.76	CHANGED	pha+lsapshh.cLsp..p+........phhlc.pGhsalstpphhsllhppappplpc..slthhtpshs..cl....pcct+..lt.hhppls................................ttht.tp..h.splstppFP.CM+plhppL...ppsp+LcHtuRhplshFL+.......................slGlsh......--slphacpth..........s.scFsc.php..YsI+HthG...........-Gppss.....YsPhs.....Cpplh.............csaG...CPh...........s.-pL..................................................................................sppttl.pHP.pYa	..........................................................................acl.satch...cLsp....pR................phhlppG..hsals....t...pp....hh.....sllhppappplpcslthstpths....pl....ppcp+..ltsl..lppls...h...t.............................tstl.shpp....l..spl.s.pp..FP.CM+plhptL...cpspHL+HtuRhQhslFLK............................uIGlsl..............--sltaa+pt.att.............hs.-cFs+...pap..YslR.HtaG.............cGpcss.....Y.sPho.....Ctplh.....t....s.t..........ctHG...CPa+p..........s.ctL.t.l..............................h.t.................lh....t.p...phuC..hh...p........................s....l...HP..aa...........................................................	0	138	224	321
+1815	PF01896	DNA_primase_S		Eukaryotic and archaeal DNA primase small subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	DNA primase synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. DNA primase is a heterodimer of large and small subunits.  This family also includes baculovirus late expression factor 1 or LEF-1 proteins. Baculovirus LEF-1 is a DNA primase enzyme [1].  Bacterial DNA primase adopts a different fold to archaeal and eukaryotic primases.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.98	0.71	-4.39	73	1657	2012-10-02 15:26:12	2003-04-07 12:59:11	14	27	1225	21	676	1488	174	154.80	19	29.20	CHANGED	FDlDhschsshcs...............h.hhh.hhhhshthh.tsltc-hu.hpp..............hhhhhSG.........p+GhHlal.....s.ppshphsshpph....h.................................................tpthsptlhpppshhhst.................................................................................h.h.hlDhplspphpp......hl+sPhsh.......cstssplsss............................lsh	..............................................................DlD.........t.............................................h...t.s.t..h.hptl..h...c-hGhps...............h.h..sSG..........s+GhHlal.............hhppth.sh....spspch.............................................................................................................................spthsppltp.pt..s...hhspt.ht.........................................................................................................................ph.h.h..lDht.ssphpshlps.....sh........ps...ss.t.lss.lt..............................................................................................	0	213	410	566
+1816	PF03604	DNA_RNApol_7kD		DNA directed RNA polymerase, 7 kDa subunit	Griffiths-Jones SR	anon	PRODOM	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.91	0.72	-4.48	22	397	2012-10-03 10:42:43	2003-04-07 12:59:11	8	6	344	96	272	368	26	32.10	48	44.18	CHANGED	YlCu...-Cuscsp.lpts-slRC+pCGaRILYKcR	.....YlCu...-Ct...pcsp...lc.t......t.-.s....I..RC+cCGaRIlYKcR...	0	81	151	225
+1817	PF00521	DNA_topoisoIV		DNA gyrase/topoisomerase IV, subunit A	Finn RD	anon	Pfam-B_55 (release 1.0)	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.44	0.70	-5.63	110	11276	2009-01-15 18:05:59	2003-04-07 12:59:11	15	57	5442	61	2091	8937	6799	383.20	48	53.48	CHANGED	RAlPcltDGLKPVQRRILauM.hc.h.hp.sppapKsAplVGpV..hupYHPHGDsSla-ulVpMAQ.sash..phsLl-spGNFGSh.sGDss.AAhRYhEs+Loclupp.lht-l-cpslcahssaDspptEPphLPshlPsLLlNGusGIAsGhATsIPPHNhtEll-uhhthl.c.s.ph...pl....hp.h..h.sPDFPouuhlh......st..pthhptYpsG...p..Gplp..lRuchph...........t...tpllITElPapsspssllc.pIscll....psp.....plp.lt..-lcDp.occ..sl+lllc..lcp...shp...sphlhst..LachTpLpsohsss.hslhcs.p...P+hh.slp-lLcpalcaRhcllp+RppapLpchpc+hc........llpthhhhh..........spl-tllplIcss.s.....tpps+p.pLhpc..lsc.....................................................................psctlL.shpLtpLTph-hp+lppEhpclppclpplcphlss...h.phhhc-Lc	...........................................RALPDlRD..GLKPVpRRlLYuM.pc.h.G................s........s.......+.....sa+KSARlV....G-V.....hGKY.HPHG............DoulY-uhV...RMAQ.sFoh..........RY.LV..DG..pGNFG..........Sh.DGDsu.AAM.RYTEuRh.ocl.u.tp.l.L............p.D..lsc....p..........TVDahsNa..Ds..oppEPtVLPu+hPNLLlNGu.o.GI.AVG..M..ATsIPPHNLsEllsushhhlc....ssphs......................hppLhp......h.....l.GPDFPT.uuhIh..........uppsIpcuYcTG.+....Gplh...hRuchchE................................ttt.ppllloElPa..p.................V...s...p...s...p.l......lc...pI.schh....ppK...............................+l......t..hI.s.......clRDE..S.....c..........+.....puhR.lVIc...l+c.....css.............sp...hl.h..Np...Lap......Tp..Lpt..sa.sh.Nh.l..........s..........l.ps.p....................Pphh..sLtphlptalpaphcllhRRptacLpKsppRhH............Ilc..GLhhAh...........tplDplI.tlIRtu.........s.........tts.......+ttLhtp..........thsc.....................................................................................Q..ApAIL.phpL.t+Lst.h.-t.cl..tEhpc.L.tpltpLttlLss..thh.plhtp-........................................................................	1	693	1331	1755
+1818	PF01556	CTDII	DnaJ_C;	DnaJ C terminal domain	Bashton M, Bateman A	anon	Pfam-B_342 (release 4.0)	Domain	This family consists of the C terminal region form the DnaJ protein.  It is always found associated with Pfam:PF00226 and Pfam:PF00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and this, CTDII, are necessary for maintaining the J-domains in their specific relative positions [2].	30.50	30.50	30.50	30.50	30.40	30.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.66	0.72	-4.08	113	11443	2009-09-12 04:15:19	2003-04-07 12:59:11	13	45	5229	30	3594	8830	3406	77.70	31	24.15	CHANGED	DLhh.pl.slohhpAllGsp.lpl..slcG..plplp....lssssps.Gphl......plpscGh...tps.........tpGDLhlplp.lp..hP..pp.l...s..s.pp+ph	.......................................slhh.pl.slsh....s.p..AsL..G.........s......p....lp......l......s.....T.....l..............c.........G...............p........lplp...............lP..s......G.......o..ps..Gpph...................Rl+G+.Ghsthpss........................tpG....DLhlplp..Vt...hP..p..p..l...s..t.ppp...................	0	1220	2251	3021
+1819	PF00684	DnaJ_CXXCXGXG		DnaJ central domain	Yamout M, Bateman A	anon	Pfam-B_89 (release 2.1)	Domain	The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc.  Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found [1].	32.70	32.70	32.70	32.70	32.60	32.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-11.02	0.72	-3.92	63	7168	2012-10-05 09:33:39	2003-04-07 12:59:11	14	35	5271	3	2059	5364	2289	63.40	43	16.70	CHANGED	CspCpGsGs.....ssssht.pCssCsGpGhhhptpp..h.hhhhphptsCspCpGpGph..h..pc.CppCpGpG	...................CcsCpGoGAc...........sGop...sp.....TCspCpGsGplphp......p...............Ghhphpps......CspC.pGpGph....I........c-PCppC+GpG................	0	693	1292	1727
+1820	PF03265	DNase_II		Deoxyribonuclease II	Mifsud W	anon	Pfam-B_4508 (release 6.5)	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  --amino -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.03	0.70	-5.43	37	585	2009-01-15 18:05:59	2003-04-07 12:59:11	10	37	128	0	441	567	4	252.60	21	48.86	CHANGED	hoChsppu.................psVDWFhlYKLPp.............GhpahYhDs....ss.ssWphustslsss.p.sslspTlpphh....ssspsshshlhYNDpPP.....ptps...ssphuHsKGVlhhcpp...pGFWllHSlPc.FPshs....hu.YsaPssspphGQphlClohshpphpp.IuptlhhppPhlYsssl........Psths..sph..spLpplspspph...........psshpppstlpohpG....tphptFuKss.passDlYs....shluptLpsslhlppWtpsss...hLsosCs.ssa.h.shshp.lsl..sp.....aspppDHSKWsVs............ssssasClG-hNRptppt+RGGGslChp............stplapsFpphst..php.sC	..................................................................................................................................................h.phh....hhhKh.st.....................................t.thhhhps..................ts..ttht......t..............h..st....t...tshtt.oht.h.......................tpt.......phhhhhYNstsP...........................t...............tt....h.....upsK..............G........l....lhh....spt...........tu.h.Wl.lHohPt.FPs......................s..a.........h.P.....s......t.....................................................Gp.hlChoh.t...t.p.....hpt....ls........t........lhh.tts.la..ph.................................s..t............t.h.......h.p...lhpt....................s..........hto...ts.......h..auK.t...t............................-ha.......................thl....h...h.t.t.s.h.s.........W.........tttt........s.Cp.................h..h...t..hth...t.t..............................ht..ttDp.up..ahls.....................tshhChss.sh.......tp..psuhhhCh................lht.hp..h....................................................................................................................................................................	0	336	365	405
+1821	PF01712	dNK		Deoxynucleoside kinase	Bashton M, Bateman A	anon	Pfam-B_1744 (release 4.1)	Family	This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76  and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine  and deoxycytosine.) These enzymes catalyse the production of  deoxynucleotide 5'-monophosphate from a deoxynucleoside.  Using ATP and yielding ADP in the process.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.82	0.71	-4.29	14	2493	2012-10-05 12:31:08	2003-04-07 12:59:11	14	11	1392	149	635	1837	992	145.40	25	62.65	CHANGED	hQhhhLspRh+.hhs.........pppshlh-RSlassphlFspshhcpGphspp-aphYppha-thh.phsp........cllIYLcss.-sslcRIc+RuRs.E..........sIsh-......Yh-pLc......thatthhpphshsshhhlcsschDh.ts.pc..phhpplh	.........................................................hQhaFLspRacphpc..................ttts.hlh.-R..S..la.pD.th......lF.t.p.t...h.h.cp.....G..ph......s..c...p-.aphYpcl.a...ch.h.h.pph.h.................................PD..llIYLc..s.sh-s.h.h.cR.....Ipc....R..GR..sh.E....................p.l.s...c..........................Yhc.p.Lp...............ptYcp.a...h........p....p......a....s....t....s....s......h...l...h..l...ss...sp..h.Dhhps.psht.......h..................................................	1	202	359	503
+1823	PF00404	Dockerin_1	celCC;	Dockerin type I repeat	Finn RD	anon	Prosite	Domain	The dockerin repeat is the binding partner of the cohesin domain Pfam:PF00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1]. The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.28	0.73	-6.42	0.73	-4.01	130	1647	2012-10-02 16:17:27	2003-04-07 12:59:11	13	223	55	24	504	1211	47	21.00	49	5.22	CHANGED	DlNsDGpVsuhDhhhl++alh	..DlNuDGplNShDhslLK+YlL......	0	294	503	504
+1824	PF04118	Dopey_N		Dopey, N-terminal	Wood V, Finn RD	anon	Pfam-B_17466 (release 7.3);	Family	DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organisation of multicellular structures  in the filamentous fungus Aspergillus nidulans. DopA homologues are found in mammals.  S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis [1].	25.70	25.70	25.70	25.70	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.97	0.70	-5.65	37	385	2009-09-17 06:44:01	2003-04-07 12:59:11	9	9	257	0	258	391	0	285.80	37	15.96	CHANGED	pDt+h++asssl-+sLppF-o.lpEWADhIuhLu+L.KuLQ......ttsshshlPp+hhVu+RLuQCLsPsLPSGVHpKALElYshIFphlup-s...Lsc-LslahsGLhPhhuaASloV+shhlplhEpYhl.sLsp.sLcsshpullhuLLPGLE-EsSEhappshpLl-plp..ptlsps..............hFapslalsllsssphRLuuLsalsp+hspht........................................tpptp.hlss-ssLll+ulssuLsDc.......slLVpRshLDLLlpphPLsS....sl........l....stpDpphLlhushtlhh++DM.SLNRRlasWlLGspspspsst........pu	...............................................Dt+aRpYsusl-+ALppF-t..spEWADhIShLu+L.KsLQ...........................ps.ph..t.hlPc...+hhluKRLAQCLpPuLPuGVH.KALEsYphIFphlG..sct.............Lu+DL.lY...s...GLhPlLuhAuh..sV+............PhlLsLhEpahl.sLsp.sL+PuLpuhlhulLPGLE..E.sSEha-..+o.pL.l.pplp..ts.lspp...................................hFapsLWhull...sssuhRlsulsalhp+ls+hh...........................................................................................................hp..ptthh.....lus-...tLhlculssulpDp.......slLVQRshLDlllhthPhps....sh................hppsDh.hllpuuhtsll..RRDM..SLNRRLasWLLG.c.pt.....st.t.....................................................	0	92	133	203
+1825	PF04556	DpnII	DpmII;	DpnII restriction endonuclease	Kerrison ND	anon	DOMO:DM04410;	Family	Members of this family are type II restriction enzymes (EC:3.1.21.4).  They recognise the double-stranded unmethylated sequence GATC and cleave before G-1 [1]. http://rebase.neb.com/rebase/enz/DpnII.html	20.90	20.90	21.30	20.90	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.67	0.70	-5.34	19	239	2012-10-11 20:44:43	2003-04-07 12:59:11	7	3	216	0	35	188	11	259.50	38	88.94	CHANGED	cpac.FlpohpsTstshsYaVsapKVpcNlpp..hc...lcLNhLNhLIGcc..slcp-hhpLhpchPpllpslPhLlAlR-pphchhh..............stptsh.........shhphsFpp......hs..pl..-phhcFhcpTGLh.clhppptl+sLsDYVhGVEVGLDoNuRKNRoGchMEtllcphlpchs....shp.ahpQhphstlcch...auh-ls.....shtp++FDFsl..cspcKlYlIEsNaYsuuGSKlppsAppYpplspclp.tpsshcFlWITDGpG.W.pouKspLpEuFcplshlaNLphlcpuhLcclh	..................................t..Fc.alpshp.sostshsaasDapKlhcNlpplc..lpLNhLN.L..lG..pc..slppchhpLhpphPchhpslPlLlAhRppph.hh..........stptsh..............phsF..pp......hs.....h..-phh.FhccoGLh.plhps+hlpsLlDYVhGlEsGLDoNuRKNRoGchMEsllpphl.ppts....shs.........ahcphph...p...c...lcch...ash-ls.............sps.K+FDFVl.....cspphlYhIEsNFYuu.uGSKLNEsAcuYpplupc.hp.shsshcFlWlTDG.p.G.W.hsA+ssLpEsFc.....hl.hlYNlspl.cpshlppl.h..........................	0	15	27	33
+1826	PF04244	DPRP	DUF426; 	Deoxyribodipyrimidine photo-lyase-related protein	Mifsud W	anon	COG3046	Family	This family appears to be related to Pfam:PF00875.	21.00	21.00	21.20	24.00	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.55	0.70	-4.82	107	598	2009-09-14 12:31:16	2003-04-07 12:59:11	8	3	588	3	197	601	2407	216.30	32	43.34	CHANGED	LhLlLGDQLststuslpt....stsps.hllhsEstpEss.....YVtHHhQKlshhFuAMR+FAppLcppGapVtYhpL-.-....ststt..slsstLtchhppp.thpplthpcPsEaRLtpplcp.htt..thslsl.phhsss+Flssts-hpsahp..s.+KphpMEhFYRcMR++hslLMtsss.pPhGGcWNFDs-NR+phst.sh...phPpshpFpsD...thspcllphlppchs..sph......Gslcs...Fha	....................lhLlLGDQLs...ptuhhpp.....spspshhlhsElppEss.....YVhHHhQKlshhFuAMRpFAptL.ppp...GapVpYlplDs...stsht....shsstltph...hpph.t.spplphpcPsEaRLhpplpp.h.t..................hsl............sl...phhssc+FLsshs-hspahp.......s..p.....KplhM.EhFYRcMR..++hslLM....s.....ss...pP...hGGpWNaDs-NRcthsps..........phP.pshpass.....D.....spplhphlcpphh..sphGplps...h.a.................................................................	1	60	128	166
+1827	PF05219	DREV		DREV methyltransferase	Moxon SJ, Bateman A	anon	Pfam-B_6662 (release 7.7)	Family	This family contains DREV protein homologues from several eukaryotes. The function of this protein is unknown [1]. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.74	0.70	-5.52	3	166	2012-10-10 17:06:42	2003-04-07 12:59:11	7	4	121	0	102	1665	951	221.30	40	80.85	CHANGED	WYssN+E.Ls-shQulFVsShPDusTQpFL-NSpclSuNlFhQLaHuLusSILShFMS+TDINGhLGRGSMFlFSE-QFpKLLsIst.p.sSs.cs++LLDLGAGDGEITc+MuPaFEE........VYATELSpTMRsRLpKKsYNVLotlE.WQpTshpaDLIoCLNLLDRCasPhKLLcDI+s.ALcP.NGRVIVALVLPapHYVEsNs.G+ap+PcslLElsG..poaEEcVs+hh.EVF+sAGFcVEAWTRLPYLCEGDMaNSaYaLsDAIFVLKP	...................................................................................................................Y..p.p..ls..phtshFlt.....DptTp.FLppohphSs.hhhpha.+shspslh..p.hFhopTslNGh...L....tR.GuMFlhS.pQ.apcLL..p.h....s.................................s................p.s.......p..........p.....L.L......DlGAG.DG....p..VT.t.h.h....u...s...h...F...p...c.........................l....a....s....T.......E.....h..S.........................s.........M.......h.........h..............p........L.........p.........c..........+..........t........a................p............V.......l........s.....h........p.....-........a.......p.........p........p.........s.......h........p..........a.....D........lI....o...C....L....N....l...L.D.....R..C..-......p...P...h..s..L..L...ccl+p.sLpP...pG.h.l.l..L...A....l....V...L...P....a.p.s..Y..V.E.s....s....s.........p....p..pP..p..c.h......L....p..h......pG........tsaE.....-..p..l..s..p....h...p.V.h.t..sGF..l.ta...o...+lPY..LCEGDhhpsaYhLsDslhVLp..........................................................................................................................	0	41	52	81
+1828	PF02635	DrsE		DsrE/DsrF-like family	Mian N, Bateman A	anon	COG1553	Family	DsrE is a small soluble protein involved in intracellular sulfur  reduction [1]. This family also includes DsrF.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.48	0.71	-4.06	254	4389	2012-10-01 20:53:36	2003-04-07 12:59:11	10	5	1987	31	1183	3383	682	116.50	19	88.08	CHANGED	phlhhlsp.......sst.sphshthst...ss..tths.............hclt.lhhhusulthhhp............................h.....tp..thptLtp.t.....lphhlCtsuhpppuls.pp.............l..........phthsuhs.plsph.pp.u...phlph	..........................................................................................hhhlhpts.sh.ust.tstpuhph.s.....uh...tt.s..............tclt..lFhhs-.GVh..thhp....................................................s.tthsh...................hp....thptLst.ts......lplhlCs.ss.h....p....t.R...Glsttp................sL....h.......sh.ph.sshs...t.L.sphh.hp.s-.pllph................................................	0	373	740	996
+1829	PF01916	DS		Deoxyhypusine synthase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [1].	21.00	21.00	21.60	23.00	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.65	0.70	-5.29	7	956	2012-10-03 09:55:27	2003-04-07 12:59:11	12	6	712	6	524	948	1511	277.10	35	85.61	CHANGED	hptLlchhtphGFQAo.plGcAscIhcpMhcp+..................p..pchslFhGYTSNlISSGlRchltaLVpcphlsslVTTAGGlEEDhIKsLus.thlG-atlcsppLRccGlNRIGNlhVPN-sYptFE-ahhsIh-phlp.pp....p.s..............hTsSchIaclG....Kcls...cEcSllYWAaKNpIPlFCPuLTDGSlGDMLaFaphcs.stpLplDlspDlp+lNshuhpu+csGhIILGGGlsKHaIhNAsLhRsGsDYAVYIsTup.aDGS.SGA.P-EAVSWGKI+scAchVcVauDAThlFPllVAtshs	.......................................h...lhpth...p.h.G.FpA...s.plucAhch.h.pp.Mhp.c.........................................t.spl.FLuhoushlouGl.R.c.h.lt.LlpcphV-slVoTuu.sl.E.E.Dhh.....cslu........p......a......h......G.......s.......a.......s.......h.......s.............s.t.p.LRppGl.NR...IsslhlP.p.-.s.a.p.t.h.E....c.al.h.s.lh-p..hhtcpp...................................................................aospchltc.lG.........ccIs.........sc...s....S.lhhhAhc.........p.......s.lPlasPulsDuSlGs...h.l..a....h...a....s.....h.....c....s...........s....t................l...........h.....l..D.h........l....p............D.h......pplss........h..............s...h...p........u.....p................c........s.......G....hlh....lGGGlsKca.........h........h.......s........s........s........l......h...........+.......s.........G...........t.......-........Y.....u...l........IssupphDGS..SGApPcEAlSWGKl...c...h...s...u...p....s...p............VauDATlshPLlsu.hh.......................	0	196	337	452
+1830	PF01323	DSBA		DSBA-like thioredoxin domain	Bateman A, Mifsud W	anon	Bateman A & Pfam-B_2082 (release 6.4) & Pfam-B_5982 (Release 7.5)	Domain	This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways [2,3,4].  This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. Swiss:P24473), whose similarity to HCCA isomerases was not previously recognised.  The sequence Swiss:O07298 has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence Swiss:Q9ZI67 has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum Swiss:Q52782 protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see [5]).	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.94	0.71	-4.75	30	5572	2012-10-03 14:45:55	2003-04-07 12:59:11	15	31	2655	78	1612	6482	3933	172.90	17	79.27	CHANGED	plchaFDahCPaCahuppplpphtpth................s.lclph+shslhss.....s.s..............p......th.......th.h.............sopputplhhhsttps....tphspthapshaspstshscps...ltplspcsGl.-ssp...hpphhsu...ssspstlccspptAtphultGlPshhl...ss......c.....hhhGssph-hltptlt	.................................................................................................l..ah-hhCPa.C.a.h.h.p.t....h....l.p.t..h.hpth........................................s..h..p..l..p..h..p...s.h....t...lhst...................................................................................................................................................................................................h..sshp...u.h...p.h..h...h.h.s.t...tps........................p..h..h.ts.l...a....c....u....h.....a.....p.....p........s......p......s....l....s.....s.......s......p.s...............l....t....p....l....h....t.....p....s.......G.........l...s.....t...t..p.................h.p...t...s.h...s...s.............s...h..p...s.t....l.....p.p...p....p....p.......t.......A..........t.......p...........h.........s....l..........p..........G.l..Ps.hll.........ss..........c...........hh.......G.t....t.h.....h........................................................................................................................	0	421	907	1308
+1831	PF02600	DsbB		Disulfide bond formation protein DsbB	Bashton M, Bateman A	anon	COG1495	Family	This family consists of disulfide bond formation protein DsbB from bacteria.\	  The DsbB protein oxidises the periplasmic protein DsbA which in turn oxidises cysteines in other periplasmic proteins in order to make disulfide bonds [1].  DsbB acts as a redox potential transducer across the cytoplasmic membrane and is an integral membrane protein [2]. DsbB posses six cysteines four of which are necessary for it proper function in vivo [1].	22.10	22.10	22.90	22.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.26	0.71	-4.43	184	2959	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	2169	13	514	1795	1819	155.50	23	77.26	CHANGED	M...............pt+thhhlhhlsuhshhhs.....AL.ahpal....hshtPCsLClhQRhshhslsllslluhht.........hchh.hhhhhlh.uhhGhhluhhHshlptt....t....sCs.........h.t.hshtphh...lhts.sss.Csphsap.h..lG................lohstWsllhFhhlsllhlhhhh	.................tht....t+hh.hhlhh.h.ss.hslhhs.....A.h.aaQal....hthtPCsLClhpRhshhshshsu.lluhlt...............hshchh...thh.hhl.h.uhhG....l....t....luh...p....H......sh......lphh..............Ps.s..h.s.....sCs.....hh.t..h...phh...shtphh...h..hhs...sss...C.sth...ht..h..hs.....................................lphsthth.hhFhhhhllhhh.h.h..................................................................	1	116	272	395
+1832	PF02683	DsbD		Cytochrome C biogenesis protein transmembrane region	Bashton M, Bateman A, Eberhardt R	anon	COG0785	Family	This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange  proteins.  These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.65	0.70	-4.73	10	5377	2012-10-02 18:22:22	2003-04-07 12:59:11	10	29	3528	0	1358	4319	2426	206.50	25	49.26	CHANGED	uFLAGlLShLSPClLPllPlalSaIoshshssh+pt.........hhpulhFlLGhollFluLGhusuhlsslht.tatshlphluulllIlhGLphluhh.................hLh+hphs..............................h...tpsps.hltuhLhGhsFAluWoPChuPlLuullshuusps..hhushhhslYsLGLulPhllsulFhs.hh....hh+tlp+ap+hlchsoGlLlllhGllhlh	...........................................................hluGll...h.h.o..P.C...l.LP.l.l...Ph...h...h.u.h.l...h....u........t.........p.......t....t...t.........h......p..tt.............................shh.t.s...h...h.a.l...h...G...h...u...l...s.......a.......s.h...L..........G.......h.........s...s.........u.......h......h.......G........t.......h......h.......t.............h.......t.....t..........h.......h.....h......h.....l....h...u..h........l.....h...l....l...h.......u.......L.....t...h...h.....u.h.hp......................................h..h.l...t.p....pph...............................................................p.p..p..t.s.s..t.h.h......u...s.a.lhGhhh.ul....s....h....oPC....s....u....P...s...L..u.....ul....L....s.h........s....u......s....s............u....s.......h..h..tG.s..h.h....h.h....s....a...u...L..G.....hu..l..P.h..l....l....l..u....l....h.s...s....h...hh..................h.h.....t..h...t.........t.........a........h........t..h....l.....c......t.......h...hG.h.l.lls.hulhh..h..........................................................	0	404	850	1135
+1833	PF01984	dsDNA_bind	DUF122; 	Double-stranded DNA-binding domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This domain is believed to bind double-stranded DNA [1] of 20 bases length.	26.00	26.00	26.60	29.70	25.60	25.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.38	0.72	-4.05	62	498	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	448	6	336	484	53	104.50	33	78.93	CHANGED	IR+p+h..tELQpp.............t.tttpppppppppt..........ctp+pulLpplLss-AR-RLspl+LV+P-hApsVEs.LIpLAQoGplpp+lo-cpLhplLpplspppcpp.....cIphsR	...................lRtt+htpLptp.........................ttttpptppp.ppppt...............................ppt+pu...lL...pQlLss-ARpRLuplpLVKP-+ActVEshLIphAppGpl.p..tKlo-cpLhplLpplspppcpp.....tplphpR...................	0	107	189	274
+1834	PF04077	DsrH		DsrH like protein	Kerrison ND, Finn RD	anon	COG2168	Family	DsrH  is involved in oxidation of intracellular sulphur in the phototrophic sulphur bacterium Chromatium vinosum D [1].	24.40	24.40	24.80	24.60	23.80	24.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.01	0.72	-4.32	66	948	2012-10-01 20:53:36	2003-04-07 12:59:11	7	1	944	13	166	473	50	86.00	41	91.11	CHANGED	+SPapstslpssL+hl....sssDslLLlpDuVh.Ashsssphhptlpt...pshplasLpsDlpARGl..tplsssl.........ph.lDYss..FVcLshc.Hpps.	........................SPa.s.-hsulLRLL....s-GDs..LLLlQDGVh.AAl......cu.sc......aLcsLps.............uslplYALpEDl..hARG...L....s...u.pl..S..s..s..l.........hh..lD..Yo-..FVcLTl+Hspp................	0	38	74	123
+1835	PF05160	DSS1_SEM1		DSS1/SEM1 family	Wood V, Mistry J	anon	Pfam-B_22209 (release 7.7)	Family	This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homologue SEM1, both of which are short acidic proteins.  DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe [1].	20.80	20.80	22.60	23.20	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.48	0.72	-4.19	28	295	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	233	7	210	264	3	62.30	45	64.59	CHANGED	ptspp...chssLE..EDDEFE-FPh--..Wssccsppsss........plWEEsWDDDDs.sDDFSpQL+pELcps	....................................t..tpt.chshLE..EDDEFE-FPs--..Wssp-...p-pss..................plWE-s.....W.....DDD.-l.pDDFSpQL+tELcc...................	1	67	115	171
+1836	PF00908	dTDP_sugar_isom		dTDP-4-dehydrorhamnose 3,5-epimerase	Bateman A	anon	Pfam-B_540 (release 3.0)	Domain	This family catalyse the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	20.30	20.30	20.40	20.80	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.20	0.71	-4.95	19	3552	2012-10-10 13:59:34	2003-04-07 12:59:11	12	9	2817	55	902	2953	1971	172.40	40	87.60	CHANGED	hhchslssshllEPclFsD-RGaFhEoFspptFpctsstt.shVQ-NcShSup.GVLRGLHaQh.s.sQuKLVRslcGpVaDVAVDlRpsSPTaGcWsuVpLSs-N+ppLalPtGFAHGFhsLu-c.schhYKsoshYssppEpulpWsDPslGIcWPhtss.........lStKDtsus.hs-h	...........................................h..pstlsslhll-P.p.lFuDpRGaFhEsap..pc..p.....F.p......c......t....s.........h..............p.........t....s..........F.....V....Q.-.N.pS.hSpc..GVLRGLHaQht.............sQ...uKL.Vpll.p.G..p..VhD..V.sV..DlRcuSPTFGpWhu.shL....osc....N..........p....+plalPcGFA.HG.FhsL.o.-....s..sp......h.h..Y...Ks..s...s...a..Y.s...P.p...t...-...t...u...lt..asDPslu.IcW.P.h.t....s....t....................hlS-KDtttshLtcs.....................................	0	286	589	765
+1837	PF03942	DTW		DTW domain	Bateman A	anon	COG3148	Domain	This presumed domain is found in bacterial and eukaryotic proteins.  Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.	19.70	19.70	19.80	20.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.34	0.71	-5.11	13	1690	2009-01-15 18:05:59	2003-04-07 12:59:11	10	14	1061	0	506	1210	69	187.30	32	78.80	CHANGED	RthtCtcCtlshptCLCshl..PslpspsplhllpHssEst+shsTuhll...shsltcs.hhth.ch.t.s.p...........................h..hhttPshpshllFPucputshpcl..................................................hshssschhphIllDuTWscA+cha+psshL............csLP.pVsLtsptsSpYR.lR+usscspLsThEsuthhLshhpsp............cu.tpsLlphhcsht.paphspt	..........................................................................................h.tC...p.Ch.hs...p....h....ClCstl.........sshp....s....p...s..........phhllhassEs.h.+.s..o.N.TGRLl................ut.hl..s..c..s...t.s..a.....a..sRs..psstp...................................................................................................................................L.ht..hl....p..s.s..s.....h...p.shllF.P....u.p.h....u...tp..h..p..p....l.........................................................................................s....s..ss.+......sh....hI.h.L..DGTWpcA+KMa+.+.S.PaL...............................................................psLP...hls..l.s........s......p..h....S......tY..+....lRcsp..s...........psphsTsEsuht....lLphhscp.........................................ps.spsLh.phFpthhppa.h..pt...............................................................	0	139	241	393
+1838	PF01950	FBPase_3	DUF100; 	Fructose-1,6-bisphosphatase	Enright A, Ouzounis C, Bateman A, Mistry J	anon	Enright A	Family	This is a family of bacterial and archaeal fructose-1,6-bisphosphatases (FBPases).  FBPase catalyses the hydrolysis of D-fructose-1,6-bisphosphate (FBP) to D-fructose-6-phosphate (F6P) and orthophosphate and is an essential regulatory enzyme in the glyconeogenic pathway.	25.00	25.00	41.40	32.60	22.20	18.10	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.12	0.70	-5.46	33	184	2009-09-12 01:16:20	2003-04-07 12:59:11	11	2	177	8	111	177	25	352.60	55	96.70	CHANGED	hKlTlSlIKADVGulsGHopsHscLl-tscchLpcA.cpslLIDaaVopsGDDlpLlMTHp+GsDsc-lH.cLAWcsFhpuT.cVAK-LKLYGAGQDLLsDuFSGNV+GMGPGVAEMEFp.E.....RsSEPlllFtuDKTEPGAFNLPLY+MFADPFNTAGLVIDPsMHpGFpFEVhDVh.....-sKplhLssPEEhYDlLALIGssuRYVIK+Vap+.tsGc....l.....AAVsST-RLshIAG+YVGKDDPVsIVRsQSGFPAlGElLEPFA.hPHLVuGWMRGSHsGPLMPVshccAps..........TRFDGPPRVhALGFQls.cG+LlGP.sDhFcDPAFDhsRcpAtclA-ahRRpGPFpPHRLP.-EMEYT.TLPpVlcKLcsRFpsh	........KlTlSVIKADlGuhsGHshsHPcllctApchLp-A.ppslllDaaVopsGDDlpLIMTHp+GhDsp-lH.tLAWcAFppuT.cVAKcLtLYGAGQDLLpDuFSGNl+GhGPGVAEMEFpE......RsSEPlllFhADKTEPGAFNLPLY+hFADPFNTAGLVIDPsMHpGFpFEVhDlh.....EpKtlhLssPEEhYDlLALIGssuRYlI++Vap+.t.....sscl......AAVsST-RLshIAG+YVGKDDPVsIVRuQuGhPAlGElLEsFu.hPHLVuGWMRGSHpGPLMPVshcsAp..s..........TRFDGPPRVhALGFQlp.cG+LlG.....P.sDlFcDPAFDtsRppAhchA-hhR+pGPFpPHRLP.-EMEYT.TLPpVlcKLcsRFt.h............................	0	41	74	94
+1841	PF01954	DUF104		Protein of unknown function DUF104	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes short archaebacterial proteins of unknown function.\	      Archaeoglobus fulgidus has twelve copies of this protein, with several being clustered together in the genome.	21.60	21.60	21.80	21.70	21.10	21.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.93	0.72	-3.94	41	145	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	53	2	106	172	12	61.20	27	89.62	CHANGED	MsclI-AlYEsGVhKPLcKlcLcEGc+lplhlppt.........-lhc+htshlttpp.......t..pchlcE	....M.phIcAlYEsGVhKPL..cpl.c..LtEGpc...VplhIppt...........c.hcchhthht.t........................................................................................	0	46	70	92
+1842	PF01955	CbiZ	DUF105; 	Adenosylcobinamide amidohydrolase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This prokaryotic protein family includes CbiZ which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route [1].	21.00	21.00	21.00	21.20	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.35	0.71	-4.51	69	333	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	295	0	160	338	10	191.00	28	66.29	CHANGED	llchtpshpslSoushsGGhtp.sctlhNppVsp....sass...........sspphh.pchhpph..uh...psssuhhTAssh.cphshs....cshpVpshsTAGl.sNssphu..................................GTINlhlhsstsLscuAhspulhTATEAKstALh-hsl.........tuTGTuTDulsVss........tt..stthpauGstTclGphlucu....VhcAl	......................................h..phstshpslSouhh.sGGhtp.hptlhNtp.Vsp...shspt...............sstphh.pphhpph..uh..................psssuhhTAssh.cphshs..........c..s..h..tVtshsTAGl.sNuscsut..........................................................GTINlllhls.....ssLssuAhspAlhTsTEAKstAL.-hsh....t..................hATGTuTD.ulslss.........stt....stthpauGstTplGphlu+u....Vhpul........................	0	62	111	139
+1843	PF01956	DUF106	DUF106; Methyltrn_RNA_3;	Integral membrane protein DUF106	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function. Members are predicted to be integral membrane proteins.	25.60	25.60	26.00	25.70	25.50	24.80	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.72	63	665	2012-10-01 21:53:17	2003-04-07 12:59:11	11	4	418	0	446	621	77	171.30	25	75.18	CHANGED	slllss.lp......hhPhhllllllullpshhupllpthh..pp..sph......phpppphtpctcphpp.........................sss.thp.cphppccpthhpsppph.................................hhphhKs.hhhhlsphslhhWlshhFu....................Ghll.......t+lP.FPlhtphpthhptsl..tshssthso.lsWYFLshh.ulpplhphl....LGhss	............................................................................................sh..llhlhlullpthls.hl..p.........+p...sth.............phpc.pp.h....hcuctLcp...............................ssp.hht.tpp...h.ppccphhts.sppsh..............................................hhs.h.h.Kuthsh....hls.hhllh.ual..Nhh.Fs...........................GhVl.........sKlP...F.P..l..hh..thpshh.p.....pGl............shD...s....shs.......S.......lsWYF.Lssh.ulpphhphl.LG.s..........................................	0	142	240	363
+1844	PF01957	NfeD	DUF107; 	NfeD-like C-terminal, partner-binding	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	NfeD-like proteins are widely distributed throughout prokaryotes and are frequently associated with genes encoding stomatin-like proteins (slipins). There appear to be three major groups: an ancestral group with only an N-terminal serine protease domain and this C-terminal beta sheet-rich domain which is structurally very similar to the OB-fold domain, associated with its neighbouring slipin cluster; a second major group with an additional middle, membrane-spanning domain, associated in some species with eoslipin and in others with yqfA; a final 'artificial' group which unites truncated forms lacking the protease region and associated with their ancestral gene partner, either yqfA or eoslipin. This NefD, C-terminal, domain appears to be the major one for relating to the associated protein. NfeD homologues are clearly reliant on their conserved gene neighbour which is assumed to be necessary for function, either through direct physical interaction or by functioning in the same pathway, possibly involve with lipid-rafts [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.79	0.71	-4.05	29	3477	2012-10-02 01:11:51	2003-04-07 12:59:11	13	7	2863	3	986	2665	624	137.70	20	67.86	CHANGED	hhlllGhlLlshEhh..hsshuhluhuGlsuhllGslhlhs...................hshhhshtlhhhhhhshlthhlh+t....+pppss.psh.....csllGcpupl...ts...hhsspGhlplcGphWpsput-....lttGcpVcVluhcGhsLhVpcps	............................................................hWlhlu.hlL...l..hhEh..........hssh...h..h..h.....h.h.s..G..l...u..u...h..l..s....u.h.lh.h.hh.........................................hs.hh.h.h....h..t..s.l.h.....h.h...h..l...s....h.l........t.....h............h.....h.....h.+...p......h..h...t...t..p.t.p.p.pt..t.................................ppl...l...G...p..pu.hl.......ps....................hs..s..s....p......G......p....l......c......l.....s.......u.......p.....t......W...s.....s...p....utss...........lts.G..s..c.V....pVlt.l...-...Gh.pLhVp...h............................	0	335	648	832
+1845	PF01958	DUF108		Domain of unknown function DUF108	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has no known function.  It is found to compose the complete protein in archaebacteria and a single domain in a large C. elegans protein Swiss:Q19527.	21.00	21.00	33.40	32.40	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.94	0.72	-3.76	65	431	2009-09-10 18:08:58	2003-04-07 12:59:11	13	7	393	4	169	403	114	91.40	37	34.30	CHANGED	pslspss..slFcGsApEAsptFPpNsNVAAsluLAu..hG............h-pspVcllADPss.stNhH-IplcG......shGphphplcshP.ssNP+TShlsAhSllp	.......s..hsctp.llFcGoA+E.....AsphaPpNsNVAAsluLAu..lG............h-pTpVclhADPsh.spNsHclpscG......shGphplplps.hPhss.NP+TSslsuhSsl.................	0	50	101	138
+1846	PF01959	DHQS	DUF109; 	3-dehydroquinate synthase (EC 4.6.1.3)	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	3-Dehydroquinate synthase is an enzyme in the common pathway of aromatic amino acid biosynthesis that catalyses the conversion of  3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) into 3-dehydroquinic acid [1]. This synthesis of aromatic amino acids is an essential metabolic function for most prokaryotic as well as lower eukaryotic cells, including plants. The pathway is absent in humans; therefore, DHQS represents a potential target for the development of novel and selective antimicrobial agents. Owing to the threat posed by the spread of pathogenic bacteria resistant to many currently used antimicrobial drugs, there is clearly a need to develop new anti-infective drugs acting at novel targets. A further potential use for DHQS inhibitors is as herbicides [2].	21.20	21.20	33.70	32.40	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.01	0.70	-5.76	26	211	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	183	0	126	218	104	339.40	38	94.02	CHANGED	KplWl..s.t..ssW-tpKchlTsuLEuGsDsVlVsp.tclc+V+cLGplplhu..................................s...h.........ht.h.......GpssusYlcIpsc-pEphAtchuc...s-alIltupDWplIPLENLIAtl.tpcscllAsVpss-EAcsAhpsLE+GsDGVLLcsc..Dss-l+chsphhcphspEp..lcLp.ApVTclcslGhGDRVCVDTCSlMpcGEGMLVGShSpGhFLVHuEThEsPYVAuRPFRVNAGAVHAYlhsPss+T+YLuELpuGDcVhlVDpcGpsRpAlVGRlKIE+RPLhLlEA..Es.cG.cclpslLQNAETI+LVss-GpslSVs-L+sGDcVLlhh-p...suRHFGhtl.-EoIIEK	.............................................................................................al...........p..+thlptulEsGh.ss.llhtt...tp.h.....tt.h.p.pl....up.h..plhs.............................................................................................h.......tt.spchushlp.lps.ppp......chAt.phup...sshsll.s.p...DWp.....lIPLENllAt..h..t......p..ps............plluhs...p...sscEAclshps..........LEpGsDGVllpsc......shs-l+clhp.......hh...........cp............s..p........pp...........lpLs.AsVTplc..l.GhGDRVCVDTsSlhc.GEGhL..VGShSpGhFLVHuEohcss.YluoRPFRVNAGuVHuYlhsPss+TpYLSELcuGccVllVc.pcGpsRpuhVGRVKIE.pRPLlLl-....Acs......sG.....cphsslLQNAETIRLl.......s.s......s......G.....p...slu....VspLKsGDcVLshhpp...suRHhGhtl.pEhIlE+...............	0	43	92	117
+1847	PF01345	DUF11		Domain of unknown function DUF11	Bateman A	anon	Pfam-B_1553 (release 3.0)	Domain	A domain of unknown function found in multiple copies in several archaebacterial proteins.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.51	0.72	-3.93	35	6559	2012-10-03 16:25:20	2003-04-07 12:59:11	13	229	570	0	1139	6240	824	72.90	27	22.92	CHANGED	sssssssssssp..ssssshssssssshtlspssssssspsG-slsaTloVoNsGsss.uss..VsVpDhl....PsGhsassso	.............................................................ssss..................................s.........h....s....p.....u.......s...l..s....s...s...K......o.....s.......s.......p...s....h..........s...s.........l......G.......-..s.l..........TY.Tlsl..s..N..s....G.....s.....s......s.....A.....s...s........VhhsDsl........Ps.G..soFlsso........................	0	455	877	1040
+1849	PF01969	DUF111		Protein of unknown function DUF111	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This prokaryotic family has no known function.	19.90	19.90	26.20	23.10	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.28	0.70	-5.66	103	749	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	627	1	290	733	394	342.40	33	95.11	CHANGED	LahDs.huGluGDMhLuALlDLGl..shch.lpptLppLsl.....st...apLphpcsp+pGlpup+lcVph.............................................................................ptpp..................c................Rp.......hs-I...tplIp.su.....sLsspl+ptuhplFppLAcAEA+VHGh.sl-cVHFHEVGAlDuIlDIVGsshul-hLs....l-c.......lhsoPlsh...GuGhVcsAHGhlPVPAPAslElL..cslP.lhs..ssh.p.....sELsTPTGAAllssluspasshPs.hplpplGYG..uGs+-hs..hPNlLRlhluc.............................tps.thpp-plhllETslDDhssEhlualhEpLhps.GAlDVhhsPlhMKKuRPGhhlsVls..pscptppltpllhpEToTlGlRhpth.pRhhLpRchtplpTshG....plpVKhuh.hsut....hhphpPEa-DspclApcp..slPlpcVhp	...............................................................................lahDs.hsGluGDMhluALlDh.......Gs.......s................p...h....l...p...tlppLsl.....tt..............hplphpch.+..p..GltutphpV.ht.................................................................................................................................................................p...ppt..........................c...............Rpht-I.hplIp.pu........s.Lsptl+phuhtlFphl.Ap.AEuplHGh.s.h-pVHFHEVGAh.D.uIlDIlGsslsl-.Ls....hcp.......lhsoslsh...GsGh.lpsuHGhhPVPsPAshclh.............psls..lht..t.sh...p.........sELsTPTGAAlltsls......s.p......a..s..........ss.hplpplGhG..s..Gp+-h.....t..hsNlLRshlhc........................................................................................tt...t.ttcplhhlEsslDDhssEhhuh.hh-tLhpt.GAhDVahpPlhMKKsRPuhhlslls.....p.pphpthtpllhpcToolGl.Rhh.h.pRhhhp.Rpht..plps.hG.....................................plplKhsh..h.....tst.................hhphpPEa--htplApptshshpplh.t..............................................	0	134	237	275
+1850	PF01970	TctA	DUF112;	Tripartite tricarboxylate transporter TctA family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [1]. TctA is part of the tripartite TctABC system which, as characterised in S. typhimurium [2], is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules [1].	20.40	20.40	21.50	21.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.26	0.70	-6.07	199	2024	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	1089	0	682	1865	3145	407.50	36	83.48	CHANGED	sLhhhhhG.shlGhllGslPGLusshulAlLlPlTas..h.....s........PhsulhhL.sulYhGuhaGGulsuILLslPGssuussTslDGasMAppGcuupALulusluShlGGhlu....slhLhhhuPhluplALp.FGssEaFsLhlhuLs.hlusluus.s.hh.............KulhushlGLhluhlGhDshsG.h.Ra.TFG..........pLh.sGlshlslhlGLFuluElltt....h..................t..ptph..tph....tt.h.h.s.....hp-htcthhshl.RuohlGshlGhLPGsGuslAualuYs........................ht++.ho..+psc..p..F..Gc.Gsh-GlsAsEuANNA...ssuuuhlPhLsLGIPGsussAlllGuhhlpG...lpPGPhlhpppsp..llaullsuhhluNlhhlllslhh.ht.h.as+.llplPtphLhPhIllhshlGsYuls....ssh.hDlhlhlshGllGahhc+hshs.........huPll........L	..............................LhhsllGshlGsllGsLPGLGsssul..A..lLLPlTau..h.............sPtu..ullhL.uulYhGuhaGGuhouILlNhPGssuulsTshDGasMA.pp.G.+.AGtALuhusluSFhGGhlu.......sl.hl.hhh...A...P..............h.LAph.......A.Lp..F..Gs...sEYFuLhlhuls.sluuh.su...p..s..hl..............Kulhu.s.h..lGLhlu.....sl..GhDsho....G.s.Ra..TF....s..s.........pLh.sGls.hlslhlG.LFul......uEllhhh...............tppp.p.t.ph.....h.t.ph..........sp...h...hhs...............hp-htp.h.h.h.shl..RuollGhh.lGlLP.G.uGAsl.......A.ualuYs...............................hpK+..hu.......+..p.sc....p..F...Gc..GslcG.lu.AP.EuANNA...u.s.s.G.uh.lPhL..TLGlPGsuss....A.....l....h.lG...Alh.laG......lpPGP...hlFs.....p.....ps.-...............l..saullsu..hhluNlhLllls.lsh....ls.las+......lLplPh.................th..LhP.....hIl...h.h...s..hlGsYu.ls..........ssh...hDlhlhlshGllGahhc+hsaP.........huPllL.................................................................................................................	0	185	421	574
+1852	PF01972	SDH_sah	DUF114;	Serine dehydrogenase proteinase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaebacterial proteins, formerly known as DUF114, has been found to be a serine dehydrogenase proteinase distantly related to ClpP proteinases that belong to the serine proteinase superfamily. The family has a catalytic triad of Ser, Asp, His residues, which shows an altered residue ordering compared with the ClpP proteinases but similar to that of the carboxypeptidase clan [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.71	0.70	-5.63	4	404	2012-10-02 13:07:06	2003-04-07 12:59:11	11	4	342	0	216	2161	936	193.70	28	59.54	CHANGED	h.hhDPhou.l.uLhWaLLFhaLlhuPphphptLlhARh+slRclppKRsSpVITMIHRQEuIGFLGIPIY+FITIEDSEclLRAIRhTPcDhPIDLIIHTPGGLsLAATQIApAL+cH.AcTpVIVPHYAMSGGTLIALAADEIIMDcNAVLGPVDPQlGpYPAsSILKslE+KsscclDDpTLIhADIucKAIpQhp-hVasLL.KDKhs-EKAKElAKhLTpG+WTHDYPLTVEcLKpLGLcVsTNVPcEVYELMELY.QPMtp+ss.VpalPsPhK...pEpsAK	...................................................................................hhh......................................................................................................................h.....c.tl.p......h.........s...h...s...I...s...L.l...l...c...TPGG....h....V.....AA....t....pI....u....p....t...l....p....p....p..s.....s.....c.....s....s............l....h...V....P...c...h.....Ah....SuGT.lIA.L.uAD...c..IlMs.sus..........lG.....P.....l.....D.....P.......p........l........t........t...........................................................................................................................................................................................................................................................................................................................................................................................tsh...................................................................................................................................	1	96	153	185
+1853	PF01973	MAF_flag10	DUF115;	Protein of unknown function DUF115	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaebacterial proteins has no known function.	33.30	33.30	33.30	33.30	33.10	33.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.09	0.71	-4.75	151	1412	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	624	0	345	1270	190	143.60	25	34.65	CHANGED	pphlpNlsphhp......hppLhs....pt....cs..slllusGPSLccp.lshl.+php....pchlIlusssuhphLhcpGIpPDhlls.lDt....hshc....h..hpph.p........slhllhsptss.chlpthpspph.hhhhsp..........hshh..t..t..........hhsGhoVuphuhplA.hthGtcpIlLlG.Dhuasps	.............................................................................hht.................hhlhusGPSLt.pt..l.hl..pt............tp..hhlhss.ss.uh.hL.hptsI.tPD.....hlh...l-t.....hs..c.............h.hpp..tp........................slhhlh.ssh.sp......ps.l...p..hh...ptpph...hhhhtps....................................hthh...p..th.................htsGh.....oVu.phuhtLA.ht.lshc...sIlhlG.Dhuas........................................................	0	131	239	288
+1854	PF01976	DUF116		Protein of unknown function DUF116	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein has no known function. The protein contains seven conserved cysteines and may also be an integral membrane protein.	25.00	25.00	26.20	25.40	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.23	0.71	-4.74	48	272	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	245	0	133	254	20	161.60	30	58.26	CHANGED	hhshhchlh......................................phhuhcc..phlpphhIplpNphhtspht...................ch.scchllllPHCLppsc...Cst+lTs.cs.pC.pcCG.+Csluclhclu-chGhc.lhllsGuohs+............+llcct+Pc....ullulAC.p-LppGhpc.........hpt...lPs..hGVl.p+ss..C........hsTpV-hpplhchlp	.............................................................h...hhhhls.....phhshpc..phlpp.hlcl...pNphh.hppht...................c.h.scchllLlPHClp.sp......C.h+lTp...ch.sC.....+cCG..+Csluslhclucch.G.hc...lhlsTGGTlA+............+hlpct+Pc....ulluVACc+DLtpGhpc.........sps...lPshGVlsp+sstsC...............hsTpVshpcl.phl.t...................................................	0	54	101	121
+1855	PF01978	TrmB	DUF118; 	Sugar-specific transcriptional regulator TrmB	Enright A, Ouzounis C, Bateman A, Studholme DJ	anon	Enright A	Family	One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter [2] in Thermococcus litoralis.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.86	0.72	-4.27	51	1668	2012-10-04 14:01:12	2003-04-07 12:59:11	14	47	710	5	702	5171	791	67.60	24	27.24	CHANGED	Lp.plGlochEucsYhsLl...ppusssup-lucpsslP+s+lYclLpsLhc+GhVphtp.up......Pt.hYpslssc	......................................thGhsph.Esc..s..YhsL.....l.......pp.u....s......h......o.....u.......p.-.l....ucp.s....u.....l....s..+......u....p.l.Y....csLppL....h....ccGh.V.ttpp..sp.....................sh.hY.tshs..................................................	0	181	429	610
+1856	PF01982	CTP-dep_RFKase	DUF120; 	Domain of unknown function DUF120	Enright A, Ouzounis C, Bateman A, Coggill P	anon	Enright A	Family	This domain is a CTP-dependent riboflavin kinase (RFK), found in archaea, that catalyses the phosphorylation of riboflavin to form flavin mononucleotide in riboflavin biosynthesis EC:2.7.1.26. Its structure resembles a RIFT barrel, structurally similar to but topologically distinct from bacterial and eukaryotic examples. The N-terminal is a winged helix-turn-helix DNA-binding domain, and the C-terminal half is most similar in sequence to a group of cradle-loop barrels. Swiss:O28174 has this domain attached to Pfam:PF00325.	25.00	25.00	66.80	66.10	22.80	20.10	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.50	0.71	-4.49	44	155	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	152	8	103	158	96	120.50	38	62.91	CHANGED	VsSGLGEGpaYlol.hYpcpFcctLGFpPaPGTLNl+lssp.t.h.htttlcphpslhI.Gap.pssRsaGuV+sassplss.....lpuA......llhPpRTpHspcllElIAPhpLRcpLsLcDGDcVplpl	..VlSGlGEGpaYlSl.hYpcpFcchLGFcPaPGTLNlclppp...hphhttl.cshpslhI.uap.pssRsaGsV+sa.splss......lpuA......llhPpR..TpHs.psllElIAPhpLR-pLsLcDGDpVplpl..........	0	26	61	84
+1857	PF01983	CofC	DUF121;	Guanylyl transferase CofC like	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Coenzyme F420 is a hydride carrier cofactor that functions during methanogenesis.  This family of proteins represents CofC, a nucleotidyl transferase that is involved in coenzyme F420 biosynthesis.  CofC has been shown to catalyse the formation of lactyl-2-diphospho-5'-guanosine from 2-phospho-L-lactate and GTP [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.46	0.70	-5.38	3	277	2012-10-03 05:28:31	2003-04-07 12:59:11	11	3	269	2	130	665	682	192.50	28	86.28	CHANGED	M+lIIPVSshNpsKTRLSshLSsEERKsLL+sMLhDVIcALcs.lD.llllScDE-VL-aAhssLGlEllcEc..+DLNsAlcQA..Fpt.E-ccVIIIPSDIPLIuKcclcclL-puuphDVVIAPuRGGGTNhLlLR.Kcuhcl+YcssSFFKHLEEARKRGL+spIYDSFYlSVDINTsEDLGEIhlHGsGT+o+EYLRKLGFoVcPc+oSchRhcVpRp	.........................................................................................hh..lllPVKpl...stAKoRLu.ss.....h.s.......s..pp....Rps..ls...h....A....M....L....t......D.....s......l.......s....A...s...t.....s......l.....s.....l....s...V..l........o....s...D...t.......s.......s....s.s...h.u..t................t..........h.....G...u.....p..l.l....sD..............s........t..........p.....s...........L....N.......s...Al....stu..............h.h...t........t....s....s....s.......s....ll.l..l....uDLPhlpsp-Ls...p.h..l..s..s..u...........t....p.....h....c.....s..h..lu.s...s..p.G.s..GTs...sL...h.h.t....s..s.t....h.....p.........s.......p..a.s.s..s..S...h..t.H...t...........................................Dls...ch.................................................................................tttth................................................................................	2	39	96	119
+1858	PF01986	DUF123		Domain of unknown function DUF123	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial domain has no known function. It is attached to an endonuclease domain in Swiss:Q58030. The domain contains several conserved cysteines and histidines.  This suggests that the domain may be a zinc binding nucleic acid interaction domain (Bateman A unpubl.).	25.00	25.00	27.50	25.60	21.20	24.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.76	0.72	-3.89	69	232	2012-10-01 19:55:08	2003-04-07 12:59:11	11	4	224	0	149	235	33	93.40	35	50.11	CHANGED	phphptGhYsYlGSAht.su.....htpRltRHhp..tst.+..............................h+WHIDYLlt..psplstl.h.hhsppc....hEstluptLsphst....l.tGFGuSDsp..stSHLahhs	..............t.hphptGhYhYlGSAh..su.....ltpRlpRHhpps+...............................ph+WHIDYLhs...psphhts..h..s.stc....hEsplAptlsphht.....ltuFGuSDCp..CtSHLahh.p.........................	0	51	97	124
+1859	PF01987	AIM24	DUF124;	Mitochondrial biogenesis AIM24	Enright A, Ouzounis C, Bateman A, Eberhardt R	anon	Enright A	Family	In eukaryotes, this domain is involved in mitochondrial biogenesis [1]. Its function in prokaryotes in unknown.	20.80	20.80	21.00	20.80	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.54	0.70	-4.88	153	1844	2009-01-15 18:05:59	2003-04-07 12:59:11	12	16	1144	7	748	1709	223	204.60	25	77.57	CHANGED	aplh.tsshphlclpL.t.sucslhscsGuMlhhs....uslphps..th............th....lhtulp........chlsGEuhFhs.hp...tspG.pGclhlAss.hsGp.lhhlcL.ss.........p.tlhlppsuaLAs.sssl....phchpht......thttu..........hhu...........Gp..Ghhhh+lp...G.pGhlhlpu...hGslhphplt..scslhVDsuplVAassslpa.......plpps.s................................................thhuth.hu...GEGl..hh.php...Gs.G.pVhlQ.ohs	......................................................................................................t.shphlplpLt..ssp..s.lh.....sc.....s.GuMhhhp...................sslphps.h.t.............................utlhtthp...........phlo.GEuhhhs.hh........tspG..pGplhhAsshs.........sp..l..h.s.lcL..ss....................tpl.hl.p..p..ssaLAh.ss.s.l.....phshpht.....th.tu......................hhu......................Gp...Ghhh.h.p...lp...........G.....pG...h...lhlpu....tGslhph.p.l...t...sc.plhlDssplVAa...ss..s...l..ph..........slphs.s.....................................................................................shhsth...hu.........GEG.l....hh..ph..p....G.s..G...pVh.lQoh...................................................................................................	1	239	508	668
+1860	PF01988	VIT1	DUF125;	VIT family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the vacuolar Fe2+/Mn2+ uptake transporter Swiss:P47818, Ccc1 [1] and the vacuolar iron transporter VIT1 Swiss:Q9ZUA5.	28.10	28.10	28.10	28.10	27.90	28.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.37	0.70	-4.85	143	2783	2009-09-13 10:13:07	2003-04-07 12:59:11	14	11	1699	0	1169	2391	416	165.10	25	72.77	CHANGED	hlRssV.hGusDGllosh.ullsGluuss...s.......s.st..slllsGlusl.lAuuh.SMuhGpYlSspupp-htptphpc.p..th.t..ptpht.phhthhtpp.Glstphspphspth.t...................t...............................................................ht.hh..thsh................pPhtuAlsosluahlGullPllsahlh....................shhholhhshlsLhllGhhtuths.s........tshhpuslchlhhGhlussloahlGtl	......................................................................................................................hpshlhGh.DGllssh.ullhGluuus.........s.....lhlsGhushluuuh.SMuhG-alSspsp............t-..tt.ht........h.........t...................h...hh.t...s...t.h......hs..h................................t..........................................................................h....tht...............s...............pPhpuAhsohhuahlG.....ulhPhlshhhh................................hthhhshh.hs.h..lsLhhhGhhtuhhs.t................................tshhpuhhc.lhhGhhshshshhlG..........................................................................................	0	357	761	1000
+1861	PF01989	DUF126		Protein of unknown function DUF126	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function.	19.30	19.30	26.90	32.90	18.50	17.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.51	0.72	-4.31	60	282	2012-10-01 19:37:30	2003-04-07 12:59:11	11	2	253	1	142	284	192	84.60	37	34.22	CHANGED	slSFhGGVDPpTGhllDhtHslhGpSlsG+lLlhPsu+GSosGShVlh.pLtpsGpAPtAllhp.csEsIlshGAllAs......lPl...lst	...................lSFhGGVDPpoGhll-p.pHsLpGpslsG+lLlhPsu+GSos.GSh.Vlh.pLhpsGpuPsAl.lhp.c.s.-sIlshGAllAp..........lPll.t............	1	42	83	110
+1862	PF01994	Trm56	DUF127;	tRNA ribose 2'-O-methyltransferase, aTrm56	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family is an aTrm56 that catalyses the 2'-O-methylation of the cytidine residue in archaeal tRNA, using S-adenosyl-L-methionine. Biochemical assays showed that aTrm56 forms a dimer and prefers the L-shaped tRNA to the lambda form as its substrate [1] [2].  aTrm56 consists of the SPOUT domain, which contains the characteristic deep trefoil knot for AdoMet binding, and a unique C-terminal beta-hairpin [3].	25.00	25.00	79.40	95.80	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.59	0.71	-4.37	31	143	2012-10-01 22:53:19	2003-04-07 12:59:11	11	2	140	4	88	146	75	121.00	48	66.03	CHANGED	WGGs..FpVchsssa+phl+ca+ptuGhVVHLTMYGhsls-lhscI+...................pscc...lLllVGAEKVPt-lY-hADYNVuVGNQPHSEVAALAlFLDRLhcGcpLpp-FtsA+lpllPpc+GKcVlct	......WGGs..Fp.lchsssa+phl+cW+t.ts.....GhVVHLTMYGhsls-.lhscI+.........................p..p..p.cs....lLlVVGAEKVPt-lY-hADaNVuVGNQPHSEVAALAlFLDRLhcG+pLpp-FpsAcl+llPpppGK+Vlph..	0	21	53	73
+1863	PF01995	DUF128		Domain of unknown function DUF128	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function. The domain is found duplicated in Swiss:O27611. Many of these are attached to an N-terminal winged helix domain suggesting these are transcriptional regulators and that this domain has a ligand binding function.	25.00	25.00	63.90	27.70	22.10	23.00	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.26	0.70	-5.43	36	122	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	69	2	87	121	4	228.30	32	79.15	CHANGED	lsFlhS+lpchhapssaD.tptpGcVllNhohlp..............ccch-pslcllccshcsG..huloshlplhccs.t.......tsplsItTlCSlThDGlLL+sGIPspPtYGGllclcstpPhRFp-lIsYcuTSlDPlclFhspshTsVhphhcsGpGtlLANlRplPhsAc-chcpllccl.t.uhsGll..plGcsspslhGlsVppsplGlshlGGlNPlsshpEtGlslchpshpslh-apphpch	............lshlhS+l.phhapssaD.pptpGpVllNhohlt..............cpphccslclhccshcsG..huloshlplhcc............psplsltTlCSlTlDGlLL+sGIPspPpaGGllclcs..tpPh+Ft-lIsYcuTSlDPlclFhsp.....shTsVhthhpsGpGplLANhRplPhsuc-chpcllccL.t.uhsGll..plGc..sspsl.hGlsVs.psphG.lshh.GGl..NPlushpEpGlslchpshpslhchpphpp.h.........	0	22	58	75
+1864	PF01996	F420_ligase	DUF129; 	F420-0:Gamma-glutamyl ligase	Enright A, Ouzounis C, Bateman A, MorningStar A, Mistry J	anon	Enright A	Family	F420-0:Gamma-glutamyl ligase (EC:6.3.2.-) is an enzyme involved in F420 biosynthesis pathway.  It catalyses the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0). This reaction produces polyglutamated F420 derivatives.  GTP + F420-0 + n L-glutamate -> GDP + phosphate + F420-n	25.00	25.00	25.70	25.30	21.70	22.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.48	0.70	-5.29	91	759	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	642	4	296	699	526	231.60	28	69.99	CHANGED	slcsh..lcs..GDD..Lspllhpuht..........lp-GDllVlupplVS+AEGRhlshsslpPu....................................Ah.lu..ht........tssph.........hplllcE...............................usclltt........tsshhlsps+tGhl.....hssAGlDp.........................SNs........sss....llLLPcDPcsSAcpl+ptlpphhGh....pVuVlI......sDohGRsaRhG....tsulAlGsuG......ltslt..-htGp.pDh.hGctLp.....................hT..uluDplAuuAsLlhGcusptsPlsllRGh	.........................sltsh..lp.GDD..lsplltpss.........................lp-sDllslopplVu+spGphsshspht.s.........................................h..hs............hs.th.......................hpllhpE............................................................................................................sscllht..........tstshlspsppGhh........hssAGlDt....................................................................................................................................SNs.........ssst....lhLhP.p-..P..cssApplpptlpphhu.h....pluVl.l......sDoh..G+.a+hG....tsshulGhsG................ltslt..shtu...hD..hsp.lt...............................sT..slsD.luuhusLshGphst.hPlsllpG.............................................	0	110	228	272
+1866	PF02343	TRA-1_regulated	DUF130; R03H10.4; 	TRA-1 regulated protein R03H10.4	Bashton M, Bateman A	anon	Pfam-B_814 (release 5.2)	Family	This family of proteins represents the protein product of the gene R03H10.4 which is located near a sequence that matches the TRA-1 binding consensus. TRA-1 is a transcription factor which controls sexual differentiation in C.elegans. R03H10.4 shows male-enriched reporter gene expression and acts as a direct target of TRA-1 regulation [1].	19.40	19.40	19.40	19.70	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.97	0.71	-4.64	23	100	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	4	0	99	115	0	124.20	26	71.88	CHANGED	clC.s.psspCPDLtshh............sshpl..s-tDGCss.loCs.suphPhhhupassSEIsss.ss..ssshshFtlhsPhohsphsu..........slhcaaGllCE....sspWphTKYPpGIthh..ss...hhGsDGShsGKKotlttlsC	.....................................t........tspCsclhs..hh......................st..h.....p-tsGCsh.loCs...ss.t.h.shlhh..tasp.SEIs.h..P..ss...s.ss....t.hh...thh...s.s.s.tt.hs..sh...............................slhsaFGllC.E....sspWhsTKYPhGlt..............Yhs......ss......hhu....ss.uphsGK..Koplt.hth.......................	0	42	42	99
+1867	PF01998	DUF131		Protein of unknown function DUF131	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function. The proteins are predicted to contain two transmembrane helices.	20.80	20.80	21.60	25.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.16	0.72	-4.61	35	123	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	85	0	87	115	3	65.00	29	72.33	CHANGED	hlGshltsht......................................pscscschGGllhIGPIPIlFGos.....pphshhuhlLAlllhllhllhhh	....................................h.....h.........................................pppcspscsGGVlhIGPIPIlFGou......pph..shhslllAlllhllhllhh.......	0	26	46	65
+1868	PF02001	DUF134		Protein of unknown function  DUF134	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaeal proteins has no known function.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.56	0.72	-4.14	4	568	2012-10-04 14:01:12	2003-04-07 12:59:11	11	5	485	0	227	751	43	94.30	39	66.00	CHANGED	M.t....+sRsR+hRhIhhp..PpVRtFhPch..stTG..K..Vhlol-EhEAlRLVDYc-hoQ--AuchMGIS+sTlWRhLTuARKKlApALlEGR..hIlhcGGEhhpc	...........................................................................RPpphR.p..lpth...Pt.h..p..hFt.Ptu.......shpp.............l.h.....L....sh.....-.Eh........E....A.l.R.LhD....h.cG.LsQp-uAppMtVSRpThtpllp..sARp.KlAcuL..lpG+..hlhlpGG.h...ht.......................	0	87	154	191
+1871	PF02006	DUF137		Protein of unknown function DUF137	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaeal proteins has no known function.	20.40	20.40	20.40	33.80	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.08	0.71	-4.89	37	143	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	140	0	96	140	121	174.20	52	69.07	CHANGED	LLhAcpPVISVNGNsAALsPcElVcLActls..AclEVNLFaRT-ERhcpIs-hL+.........cpGAp.cVLGhtsDs....pIPsLpppRupVspcGIasADVVLVPLEDGDRsEALhcMGKpVIsIDLNPLSRTucsAolTIVDNllRAlPplschsc-h+phscpcLppllppaDNcpsLpculctI	..LLLAcpPVISVNGNsAALsPcElVcLActss..AclEVNLFYRTcERhctIschLc.........c..p.GAp..cVLGltsDu....pIPsLpppRu+VspcGIapADVVLVPLEDGDRsEALs+MGKpVIsIDLNPLSRTA+sAolTIVDNllRAlPplschs+-h+p....hs+c-.LppIlpsaDNccsLpculctI............................	0	23	56	78
+1872	PF02363	C_tripleX	DUF139; 	Cysteine rich repeat	Bashton M, Bateman A, Yeats C	anon	Pfam-B_602 (release 5.2)	Repeat	This Cysteine repeat C-X3-C-X3-C is repeated in sequences of  this family, 34 times in Swiss:O17970. The function of these repeats is unknown as is the function of the proteins in which they  occur.  Most of the sequences in this family are from C. elegans.	22.90	1.00	23.60	2.50	22.70	-999999.99	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.68	0.74	-7.70	0.74	-3.51	166	2125	2009-01-15 18:05:59	2003-04-07 12:59:11	14	31	38	0	1234	2152	0	17.40	42	36.77	CHANGED	spCtstCps.sCps.pCsp	...................pCtPhCps..uCpN.GhCst...............	0	331	447	1058
+1873	PF02405	Permease	DUF140;	Permease	Bashton M, Bateman A	anon	Pfam-B_1126 (release 5.2)	Family	This domain functions as a permease. In Swiss:Q7DD59 it is involved in L-glutamate import into the cell [1]. In Swiss:Q8L4R0 it is involved in lipid transfer within the cell [2].	20.20	20.20	20.20	20.40	18.80	20.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.06	0.70	-4.85	267	4359	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	2463	0	1190	3158	944	214.40	33	75.29	CHANGED	p.phlp.phhplGhtol..........sllslhuhhhGhllulQshhtLpp.aGApsh....lushluluhlRElGPlloAlllAGRsGSAhsA-lGsM+lsEpIDAlcshGlsPlphLVsPRllAshlshPlLshlsshhGlhGGhllush..hhs...lssusahpphpp...hlsh.tDlhhu............llKuslFGhllulluCapGhp......s.puGspGVGpuoTpuVVtuhlhlllhDhl...lohhh	............................................h..hlp.phhtlGstol.........sIlsls.ulhlGh.V.lulQuhhhLsp...aGApsh.....lGhhl.uluhlRELuP....llsAllhAGRuGS.A.h.TA-lGsM+hoEplDAhcsMulcPlphLlsPRlhAullshPlLshlsshl.Gl..hGGhllush..hhG.........lssGsah.s.thps.....hl....s....h.tD.lhhu............l.lKuslFuhhlshlusapGap.......s..p.s.....ss.p.GlGp..AoT..poV..VtuhlsllslDhllohl................................	0	329	763	1012
+1874	PF02408	CUB_2	DUF141; 	CUB-like domain	Bashton M, Bateman A	anon	Pfam-B_1716 (release 5.4)	Domain	This is a family of hypothetical C. elegans proteins.  The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.59	0.71	-4.56	24	264	2012-10-02 11:50:15	2003-04-07 12:59:11	15	9	5	0	250	312	0	113.70	19	25.57	CHANGED	ssshsC.sssl..hstP.ssupPh.haPssasts.sssthssspsCsaplslPpGaaAplhlpsphss....psslpshDshuph...tthtssptpsa..aFssPphplslssssss.....sFuFplpW.shs	.........................s....tC...s.th..hs.s.......s.tsh...aPts.tts....s.hsths.ss.....sCsapl..s..lP....p.....G.....h..as..plp..lps.phps.......sshlplhD..sssph..................hh.h.s...s.s....t....p...sa.....ahsss.p...h..p..lpl..p...ssssss....pFthplpa.ph............................................	0	50	67	250
+1875	PF02410	Oligomerisation	DUF143;	Oligomerisation domain	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1798 (release 5.4)	Family	In yeasts, this domain is required for the oligomerisation of ATP synthase subunit 9 into a ring structure [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.35	0.72	-3.97	165	4456	2009-01-15 18:05:59	2003-04-07 12:59:11	10	15	4365	5	1086	2727	2020	97.70	36	72.41	CHANGED	hhphlspsl--cKA.pDIhllDlpp......ho...slsDahlIsoGsSs+plpAl......u-pltcph..+t...t......s.hpshphE.Gh..............................psu...cWlLlDh.G.DllVHlhpt-sRpaYsLEcLW	.....................................................................h..phlhcsl--pK.u.pDI.lslDlps...................ho.....sls..Dah..lIsoG.sS..sRp..VpAl...A-pltcph....+p..........t..............G...hpshp..h...E.Gt...............................................................s..su...cWl....LlDh.....G...D.....llVHlh.p.p-pRpaYsLE+LW................	0	374	701	924
+1876	PF02413	Caudo_TAP	DUF144; 	Caudovirales tail fibre assembly protein	Bateman A, Moxon SJ	anon	Pfam-B_1800 (release 5.4)	Family	This family contains bacterial and phage tail fibre assembly proteins [1]. E.coli contains several members of this family although the function of these proteins is uncertain.	26.50	26.50	26.60	26.60	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.69	0.71	-3.98	73	2529	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	606	0	168	1625	6	118.40	33	75.29	CHANGED	csppsapspshp......h.ps.s.hsp......................ssstls.....t......ssGpahhhss..thh.thhs........................ppphhppA-pp+ppLlppAsptIssLp..sslcLs.hho--EpspLptWpcYtshLs+.lDsosAsD......IpWPp.Pp	.......................................................................................................................a..tsht.hh.pt.h.hs..........................ssh.ls................s.u.ta..hhss...ph.h.t.hp..........................ttthh.ptA...Etp+..ppL..lptAsp..tIss..lQ.......stlc.L....s...hhT-EE.......p..spL.......pAWpcYtshLsp..VD.TS.s..APD......lpWPp.Pt.............................................	0	15	60	110
+1877	PF02415	Chlam_PMP	DUF145; Chlamydia_PMP; 	Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat	Bateman A, Yeats C	anon	Yeats C	Repeat	This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. Common for the Pmps are the tetrapeptide GGA(I/V/L) motif repeated several times in the N-terminal part. The C-terminal half is characterised by conserved tryptophans and a carboxy-terminal phenylalanine. A signal peptide leader sequence is predicted in 20 C. pneumoniae Pmps, which indicates an outer membrane localisation. Pmp10 and Pmp11 contain a signal peptidase II cleavage site suggesting lipid modification. The C. pneumoniae pmp genes represent 17.5% of the chlamydia-specific coding capacity and they are all transcribed during chlamydial growth but the function of Pmps remains unknown [1]. This family shows some similarity to Pfam:PF05594 and hence is likely to also form a beta-helical structure (personal obs:C Yeats).	20.60	12.50	20.60	12.50	20.50	12.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.18	0.73	-7.79	0.73	-3.36	528	2166	2012-10-02 14:50:22	2003-04-07 12:59:11	12	61	306	0	261	1592	95	25.80	43	6.13	CHANGED	slhFssNpu.....................................................tspGGAIhsp	........................................hhFssNsA........................................................................sspGGAIYs....................	0	105	137	231
+1879	PF02457	DisA_N	DUF147; 	DisA bacterial checkpoint controller nucleotide-binding	Bateman A, Coggill P	anon	Pfam-B_1846 (release 5.4)	Family	The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. This domain is the first and is a globular, nucleotide-binding region; the next 146-289 residues constitute the DisA-linker family, Pfam:PF10635, that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), which thus forms a spine like-linker between domains 1 and 3. The C-terminal residues, of domain 3, are represented by family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis [1].	20.60	20.60	20.80	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.46	0.71	-4.98	190	2847	2009-01-15 18:05:59	2003-04-07 12:59:11	11	19	2386	11	670	1835	550	121.00	38	40.57	CHANGED	lhpuhpthucp+hGALIVl...pcppslp..chhp.sGhh............lcuplosplLhslF...t..ssLHDGAlllps.scltuAushLPLops..ss...lspchGTRHRAAhGloEpo.DAlsllVSEEsGsISlshs..Gplh	...................................................hculphhucp+hGALIll..pc....sp...s.Lp....-hlp..oGh.......................lcu..closp.LLhslFh..s..oPLHDGAlIlps..s+It..s....Aush......LPLops..........st.......lo+-hGTRHRAAlG.l..SE.h...o....D.A.l.sllVS.EETGsISlshsGph.h..................	0	281	502	603
+1880	PF02520	DUF148		Domain of unknown function DUF148	Bashton M, Bateman A	anon	Pfam-B_1103 (release 5.4)	Family	This domain has no known function nor do any of the proteins that possess it.  In one member of this family Swiss:Q23614 the aligned region is repeated twice.	23.90	23.90	24.00	24.20	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.33	0.71	-4.29	45	259	2009-09-11 00:48:36	2003-04-07 12:59:11	12	5	28	0	213	215	1	107.00	20	48.61	CHANGED	pcsppcahsIlpN.psLThsph-splppWApp.u..lsspappFppphpspppchcpstsplIspLo....slpspLssIhsscs.TtppppptIpsLppphsp-.hsslhaltp....htpttt	...................t.pspppahtlhps..tslohsphppplptaspp.s...............lpsthppappph.psttpphppshspllspLs....ss.spLpsIhs...sps.Thppppptlpplh.pphs.c.h..l..lht.h....t..........................	0	69	84	213
+1881	PF02576	DUF150		Uncharacterised BCR, YhbC family COG0779	Mian N, Bateman A	anon	COG0779	Family	\N	20.20	20.20	21.00	20.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.69	0.71	-4.60	40	4207	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	4149	1	904	2603	1054	139.30	32	84.80	CHANGED	llpPllcshGhELhclchtpputthhLclhlD......p.-sG.lsl-DCpclS+tlSshLDs...pDPI..sp.tYhLEVSSPGl-RPLpptccFt+ahGchVclphp.shcsc+papGplhps-s......-slsl..phtsp....................plplshssls+ApL	...................................lpshlcshu.aELVclE..ahp...t....G....p....p.........hLRlaID..................................p..-..sG...lsl-DCsplScplSslLDs......................pDPI.......sp..tY.hLEVS.........SPGl.-RPLpptccat..chl..G..c.Vplp.L.....h..................s.........l..........p..........s...........c...+.......pa.pG..h..l..t..uh-s.................-plsl.........plcs..c...........................phplshspItKApl.................................................................	0	295	598	771
+1882	PF02577	DNase-RNase	DUF151;	Bifunctional nuclease	Mian N, Bateman A, Eberhardt R	anon	COG1259	Family	This family is a bifunctional nuclease, with both DNase and RNase activity [1]. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site [2].	20.50	20.50	22.70	22.40	19.60	20.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.61	0.71	-4.95	112	1079	2009-09-11 06:46:39	2003-04-07 12:59:11	9	6	977	4	436	880	532	135.00	31	73.52	CHANGED	hp..ltGlshstss.s.....sslllLp-.p..sc.....+hLPIaIGthEApuIshsl...ps.hpssRPhTHDLhtsllpshshplccVhIsslc-ss.FaAplhl...p.psp.............t.h.................................plDARPSDAIALAlRss..sPIast-cVlp.puul.hp................t-c	....................................................h.plhslthp.sp.s...tssllLc-.s......uc.........RhLPI.aIGt.E.Apu.I.uhth.......ps....hp..s..s.RPLT.HDLht...s...l...lps......h......s......tp.l.pcVh..Iscl....p...-......us..FaAcLhh........p..pst..............................................cl.DAR..PSDAlALAlRss..sPIasp-plls.pu.ul.h..........pttt....................	0	176	335	404
+1883	PF02578	Cu-oxidase_4	DUF152; Cu_oxidase_4; 	Multi-copper polyphenol oxidoreductase laccase	Mian N, Bateman A	anon	COG1496	Family	Laccases are multi-copper oxidoreductases able to oxidise a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms [1].	20.40	20.40	20.40	20.80	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.59	0.70	-5.29	132	3547	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	3384	10	808	2592	2090	224.90	32	89.31	CHANGED	aoTR.........Gho...s.h.......tuhNluhp...s.sDs...ppVtpN....Rphlspt.....hshs............hhhhpQlHusplhhlpt..................................tssh.puDullTsp.ssl........slslhsADClPlLlh..D.psp..hluusHAGW+Gss....ssIstpsl.pth.pphss.......pspcl....huhlGPuIusssYEVu....p-Vh.ptF......tpthstttthhht............................s+hhhDLhthsptpLppsGlt....tpIth.......ssh........CThsp.s-.hFaSaRR.......psps.....GR.hhuhIhl	......................................oTR.....G..GlS........ssa............suhNluhp.....s...sDs...s..ttVtpN.......RppLhpt.........................hshs..........phlahp..QlHuscVhp.lst.............................................................stsh.puDAhhTsp..s.sl.........sls.lhoADClPVLhs....s.tpss.....h.lAA.sHAGWRGhh..............sGllcps.lp..h...t...p....ss...........................sspcl.............hAhlGPuIusp..sa..E..Vu....s-lh.ptF..................hs..t......s..p..s...t..s..h..h.h........................................s+ahhDLhths..ctp..Ltp.hGVp......pIhs.........ssh........................................CThs.......c.....tc......h.........FF..SYRR........ctpo........GR...hsuhIh..................................	0	252	508	672
+1884	PF02579	Nitro_FeMo-Co	DUF153;	Dinitrogenase iron-molybdenum cofactor	Moxon SJ	anon	COG1433	Family	This family contains several NIF (B, Y and X) proteins which are iron-molybdenum cofactors (FeMo-co) in the dinitrogenase enzyme which catalyses the reduction of dinitrogen to ammonium. Dinitrogenase is a hetero-tetrameric (alpha(2)beta(2)) enzyme which contains the iron-molybdenum cofactor (FeMo-co) at its active site [1].	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-10.08	0.72	-3.91	179	2027	2009-01-15 18:05:59	2003-04-07 12:59:11	12	31	977	14	943	1863	98	94.20	19	46.31	CHANGED	tsstls...tHFG...+uptFhlh...-ss....st.shc...llcsp.................ssstt......tsstphsp.hltp...pss..ssllsspl..GssAhttLppt.Glclhp..s....sssslc..-s.lpphhp	.............................................tttlstHFG+uptFhla............-lp...................st...php.......hlppp..............................hs.sss......................ssp...sp...hsp.hlpt.........ps....s..sslls.us..l..G.tsshptLtpt..GIclht...s....stsslc..cslpth..t....................................	0	381	689	831
+1885	PF02582	DUF155		Uncharacterised ACR, YagE family COG1723	Mian N, Bateman A	anon	COG1723	Family	\N	21.10	21.10	21.30	22.40	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.83	0.71	-4.36	92	875	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	488	0	565	818	18	175.80	27	42.95	CHANGED	plalF..p.aGslVhWshs................cp....ptpphL...phlp...................................phttp.hsppp....p.E-hpahhss.ph.....................................................................pspl...ts....................DhIh.Lpst...............................................................shhtchshSpuLupSs+LshhEpplsphl....-phpplsppLsp.sG+lsh.sc+......clhchhGclhth+hplslpspll.Dp.P-hhWc...cspL-tlYptlpchh-.......lspRlplLNc	..............................................................lFlF.p.aGslVhWshs................cp......pp.pphL...ptlp.................................................th..thp.l...sptphp..sEphpahhspph....................................................................................................................................pspl..hs..........D.hIh.L..p.st...............................................................shhhKlulSpuLAQSsKLuhaEptlsphl....pp..spslPppLu...p.sGc..l.sh..s+c............................plhpphGcLathRhplNL.puslL.Ds...P-haWc.......csp.LcslYptlppaL-lspRlplLN..............................	0	179	331	483
+1886	PF02585	PIG-L	DUF158; 	GlcNAc-PI de-N-acetylase	Mian N, Bateman A	anon	COG2120	Family	Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyses the second step in GPI biosynthesis [1].	22.00	22.00	22.00	22.40	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-11.03	0.71	-3.63	137	4157	2009-09-13 21:13:25	2003-04-07 12:59:11	12	36	2321	19	1451	3457	1554	136.10	25	45.05	CHANGED	LllssHPDD-s.husGusltphtp.....p..Gtpltllsl.........os....G...............................phs........................phsth..Rpp......EttpA.s.phL.Gl........pphhhLs..........hsDsthpt........................................................hpphhpt.....ltpll...pph...p...P.........................cl.......lhsht....stss....................HsDH.psst.....t..hshp...uh	....................................LslsAHPD..D-s.hus.u.u.o.l....u....p.hsp..............p......G.h..pV..t..l.l.sh............Tp.........G...................................................................................................ph.u.p................................................phsth....Rcp.............EhppA.s..chL..Gl..........................pphthLs.....................h..D.sthtt...................................................................................................hpph.tpt............ltpll........cch........p...P......................................................sl.........l.h..o.ht..stss....................HsDH.htstpsshtA.h......................................................	0	554	1008	1293
+1887	PF02586	DUF159		Uncharacterised ACR, COG2135	Mian N, Bateman A	anon	COG2135	Family	\N	27.10	27.10	27.20	27.10	27.00	26.80	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.88	0.70	-4.80	164	2412	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	1845	9	843	2126	1620	208.00	26	88.83	CHANGED	MCG..R...asht......ts...ppltphhth................................................ttphtspaNls....Psptssllht................................................................tpt..............................h.phhpWGl.....h....P...tasc...........................ththhNARsE...............o.l..tp..+s..sF+....psh...pppR.CllPusGa....YE......Wp......................tttsp.......K......pPah.....l...........php...s......t..ps...............................................................................................................................................hhhAGlap..tapss.tt............................................................htohsllTssu.......sst.....lstl.Hc..................R.MPllL..s.t-phcpWL.........pstssttpt....h......................lsttsspstpsss	...............................................................................................................MCGR.....as.t......ts......pphht.hh.t.................................................ssp.....sp.aNlu..Psp.s.llhpp..............................................................................ptth..................h..p.hpWGh.h......P.........sWhc..............................t..hhN..ARsE...........................Th....tp......p...hF+.....tsh....ppp....RCllPssGaaE...Wp..........................ttssp.......K..........pP.aa....l........................pht......-.............s...p..................................................................................................................................................................h.hhAGlap......phts...tst.......................................................................htshsllTssA....stt.......................lstl.Hc..................R....hPllL.......s...-..t.h.cpWL.........ssp..hstttt.....h.......................................................................................................	0	251	500	686
+1888	PF01519	DUF16		Protein of unknown function DUF16	Bateman A	anon	Pfam-B_764 (release 4.0)	Family	The function of this protein is unknown.  It appears to only occur in Mycoplasma pneumoniae. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils [2].	25.90	25.90	26.00	31.60	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.55	0.72	-3.80	18	91	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	5	3	30	66	0	93.90	42	69.63	CHANGED	sFsGshsc..Kt.p......ocYVT+KQFs....EFK.D.........uscp+LpKlEscls...........tQGEQIpp.................................................QGEQIccLp.p.c....................................t.scsLplllpoLpphs.......cRLD+lEu	...........hsGshsc..+hp.......scYVTpKphs.......EaK.s..........uspQcLhKlEspls..................sQGEQIsplhphVpt..............QGEQI+pLphc.K....................................sQGcoL.p.IhpsLtthscRLDph-......................	0	30	30	30
+1889	PF02589	DUF162		Uncharacterised ACR, YkgG family COG1556	Mian N, Bateman A	anon	COG1556	Domain	\N	20.40	20.40	20.40	21.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.04	0.71	-4.78	209	4142	2012-10-04 00:26:15	2003-04-07 12:59:11	10	12	1994	1	981	2994	341	198.50	23	58.26	CHANGED	lpp.htcplppts.splhhsps...........hp-shphltclltpt...sh.................................sh.shphsl.tchhl.............hshlctsptphhchhstph......................tpthtcphhpuDhu..........lousshulA-oGslslhsspust.chhshhPpthlsls.....sh.s+lV.sshpcAhptlph.....ts.t.........th.sshsshh.................sGP.ucsu-lphhh.hshp...GPp.clpllll	......................................................................................................h..phtpphpp.s.spVhhsps.........................tp-.ssph.l.h.p.lh.pcp...ss..................................................sh.sh-scL....sEhhl......................hssl.c...p.s...p..t.p.l.tchhppph...........................................cp.phc.cp.hh.pA..-.l.G.........lousshulAEoGolsl.ssspGs.......u..RhhshlPcsplslh.....sh.p+ll.sshp-shthlph......suhu...........p.phsshhshl..................oGP..pp.s.u.Dl-..................G.Pp.chpllll....................................................	0	354	721	864
+1890	PF02590	SPOUT_MTase	DUF163; 	Predicted SPOUT methyltransferase	Mian N, Bateman A	anon	COG1576	Family	This family of proteins are predicted to be SPOUT methyltransferases [1].	20.90	20.90	20.90	21.20	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.79	0.71	-4.50	30	3767	2012-10-01 22:53:19	2003-04-07 12:59:11	12	4	3656	18	737	2319	968	152.30	38	97.90	CHANGED	M+IpllsVG+hppcalcpuhsEYtKRlspasp......lcllEltsp+t....pspshpphhccEupplhtpl..tssshllsL-hcGKthoSEphAchlcchthpGppclsFlIGGutGLssslhpcAshphShSchThPHpLhRllLsEQlYRAasIhpscPYH	.................................................M+lpllsVG+h.t..tcalppuhsEYhK.Rhsch.hp......h-llElsstKt......spstchp.p..lh.c+E..G..pp.lLutl..............ss..p..s.h.l.l......sL-lp.GK.thsS.phAp.pLppht.h........p.G.p...clsFlIGGu...G.Lu.s...slpp...p...A.s.........p...lShSphThPH.p........LhRllLsEQlYRAasIhpscPYH.............	0	246	481	623
+1891	PF02591	DUF164		Putative zinc ribbon domain	Mian N, Bateman A, Eberhardt R	anon	COG1579	Domain	Structural modelling suggests this domain may bind nucleic acids [1].	23.70	23.70	23.80	25.90	23.40	23.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.02	0.72	-4.14	93	1089	2009-09-12 00:25:18	2003-04-07 12:59:11	10	5	1080	0	327	812	391	56.40	33	22.61	CHANGED	llptY-+lRpp..pGhulstlpps....sCtGCphplssphhscl.pps..cc..llhCspCsRIL	.......llphY-+lRcp..pu..huls.lpp.p.......sCsGChhplsspphtcl.ppu......cc...llpC.pCGRIL........	0	138	262	312
+1892	PF02592	DUF165		Uncharacterized ACR, YhhQ family COG1738	Mian N, Bateman A	anon	COG1738	Family	\N	22.00	22.00	22.70	22.40	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.71	0.71	-4.02	151	2443	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	2235	0	513	1577	1908	145.40	33	64.21	CHANGED	shGslhaPhsFlhoDllsEhYGtptA+cslhhGahsslhh.hlhh...hhhh......hhs.ss.................................tshttlhs.....ssRlslAShh.AalluQhlDlhlashl.....+phtt......tp............tlWh..RshsSThluphlDThlFhs.lA..Fh......u............h...........hs.............hsthhslhhssalhK	.......................................................................ThGshsFPhhFLsTDlhsclaGtphAR+llahshhssllh..hll...lhh......hhs..h....h.............................tultth.hh.......lsRIAlAShh.AYllGQhlDlhVFs+l+pt..........+............paWl.tshuSTlhGshlDTllFhs.IA...Fh..t......................s............h..........................sppahplslssYhhK....................................................	0	152	307	420
+1893	PF02593	dTMP_synthase	DUF166;	Thymidylate synthase	Mian N, Bateman A, Eberhardt R	anon	COG1810	Family	This family catalyses the synthesis of thymidine monophosphate (dTMP) from deoxyuridine monophosphate (dUMP). The physiological co-substrate has not yet been identified [1].	24.40	24.40	25.20	24.40	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.46	0.70	-5.00	24	85	2012-10-10 17:06:42	2003-04-07 12:59:11	9	3	45	0	68	91	5	224.40	30	91.77	CHANGED	sllhp..GpaGcRhhpslhscsphp...........................lhlh-hs-..pls-hI-pscphL.p......l.-sDlllshsLHPDlshtLschhtp.sshtulIlsutssc....h...pl+cph-phshphhsPc..hCsLc...........sspshlccFsch..FGpPclclplp...sscl..pcVcVlRuAPCGuTaalAccltGhsls-hthps........uhthpp...YPCtAuhth..p.p-shlHpAGhltpcAlpcAlth	......................................llhc..GpaGcRhhpsltppsshs.........................lhhhchsc....tls-hI-p.P.c-h.Lsc......l.cuDlllshslHPDlshtLschh.....pc.ssscul.Ilsutpsc........pl+cphcphshphhsPc..hCsLcc...........stpshlccFlch..FG+Pcl-lplc.....ss..pl.....pcVcVlRuuPCGoThalA+clhGh.....plp-ht.ps........uhthpp...YPChAuhth..p.s..-shhHpAGhlt+cAlccAltp........	0	16	41	54
+1894	PF02594	DUF167		Uncharacterised ACR, YggU family COG1872	Mian N, Bateman A	anon	COG1872	Domain	\N	22.60	22.60	22.60	25.40	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.22	0.72	-4.05	29	1679	2009-12-08 16:16:35	2003-04-07 12:59:11	11	3	1585	3	582	1119	107	76.30	39	73.13	CHANGED	pppslhlplcVpPpupcsplsulpsp.....pLclplpuPPhcGKANpcLlchLu+hhpls+SslplhpGppSRpKhlhlps	................s.sslhLplhlpP+...Au..+..ss..I.s.Glcs-.........plKVslsAPPlDGpANscLl+aLuK.thcVsKSp.Vslt+GchuRc.KplcI..s............	0	177	345	468
+1895	PF02596	DUF169		Uncharacterised ArCR, COG2043	Mian N, Bateman A	anon	COG2043	Family	\N	20.20	20.20	20.30	21.30	18.20	17.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.27	0.70	-4.95	76	379	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	254	0	211	370	56	210.60	21	82.60	CHANGED	sppLtchLcLctpPVAV+hh.t...............................spc.hst....shp..ttthp..............aCphlth.AR.pG.........cshhh.ss-phsCssGusshGhtch.st...........lpsG........................phhhp.hthhps.csuc+hhcp.hPpl...ttphhullhuPLpc.ssh.....p.P..DllllhssPtQhhplspuhhYtpGs.phpsshsuhpusCu-ssshsh....hpspss.hslGCsGsRthut.hp....ccElshulPhptlpclhcsL	.......................................................s...l.phlpLptpPlulphh.........................ppp..st.....th.......tt.hp...............hC..ph..hth..Ap....p.G.........pshhh..st-s...h...s..C.huGthshGhtph.sp.............................hlpsG...................................thhhp....thhpo.-tucchhpp..lshl...tsp.......h..tslhh.u..P.Lpc..hph.....-.P....Dl..llhhssPtphhtLsps...hhappss..hpsshssht.usCusssshsh.....ppsp.s..hslGshuspthst..hp....s--hshulPhpphpchhpt.........	0	81	158	191
+1896	PF02598	Methyltrn_RNA_3	DUF171;	Putative RNA methyltransferase	Mian N, Bateman A, Eberhardt R	anon	COG2106	Family	This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA [1], and may function as a methyltransferase [2,3].	18.60	18.60	24.50	20.90	17.90	17.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.85	0.70	-5.06	23	418	2012-10-01 22:53:19	2003-04-07 12:59:11	12	7	347	2	286	396	27	273.20	32	79.92	CHANGED	slSlslPsSlls..sspshc.tTahsupIARAsslFsVsEIlla--.....................................................tp..tstpptps.......shhlsplLpYhtTP.YLRKplF...shpspL+aAGlLPPLssspHh..ppscptcaREGlslchspps................................phlslGhsc.ltlcp....tls.ssRVTVchps................tplVsPscsps.....thYWGYpVR.hspshuclFppssh.tGaDhslhsScpupslspsphphh...........................shtplLlVFGth...........ptttps.ppsc......tpspthFDt.l.NssPsQsspslRsEEAlhlsLuhLp	..............................plSlslPuSlls.......ss..ps.....c.+ThhsGpIARAsslFpV-Ellla--....................................................................................t..t....tt..p..tps..............sh.hlsplLpYh-sP.YLRK.......tlF...........Ph.+p.sL+huGlLsP...Lc.sPaHh.......pps....c.......scaREGlslpt.ssptt.t..................................shVshGh.p..c....lplsp...................tl..ss.hRVTVchsp.......................................spl..Vssppscp...thshYWGY......pVR.hs..s..sL.splhsc.ssh......t..G...YDhsIuTS.c+Gp.sl.s.ps..t.ht................................php+hLlVFGs...................................pshtts.pt.p...............st.psp.hFD..hhl....Nss.P.sQ..GocolRTEEAlhlsLshL........................................	1	82	155	230
+1897	PF02604	PhdYeFM_antitox	DUF172; PhdYeFM;	Antitoxin Phd_YefM, type II toxin-antitoxin system	Mian N, Bateman A, Eberhardt R	anon	COG2161 and [1]	Domain	Members of this family act as antitoxins in type II toxin-antitoxin systems [1].  When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin [2].  This domain complexes with Txe toxins containing Pfam:PF06769, Fic/DOC toxins containing Pfam:PF02661 and YafO toxins containing Pfam:PF13957.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.24	0.72	-4.39	156	5612	2012-10-03 00:18:00	2003-04-07 12:59:11	14	16	2448	47	1340	3995	616	70.50	18	79.79	CHANGED	hptlshs-h.+sphupllcpsppspp..llITccGcs.ssVllsh.....ccacphpc...phthhpt.ttspphtp........tthp..ts	.....................hhsho-h..+pphspllcpspps.p.....p....l.hI..o..p..p..s..c....s...s...sll.lsh.....................cpapp.h.p.......t..h.t....tt.............t.......................................................	0	421	912	1136
+1898	PF02616	ScpA_ScpB	DUF173; 	ScpA/B protein	Mian N, Bateman A	anon	COG1354	Family	ScpA and ScpB participate in chromosomal partition during cell division. It may act via the formation of a condensin-like complex containing smc that pull DNA away from mid-cell into both cell halves. These proteins are part of the Kleisin superfamily.	23.70	23.70	23.70	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.71	0.70	-4.79	11	3012	2012-10-01 19:44:35	2003-04-07 12:59:11	9	6	2925	0	778	2298	2016	209.20	27	81.05	CHANGED	Llpctclssa-VslsclT-pYlphlcph.ppL-Lch.......sschllhAuhLlchKucsLLs....tpp.-p..-.t....phc-thhtcL.....h+tttc.hcchchpth...tphs+c.sshcchlctlcc...th.cl-c......shht.htth.hh.c.thtsthcchp.........p.hclslE-phpELlt.............p.h.tl...s.hhsa.pLh............hshhclVssFlALLhLhpsptVplpQc-.au-lhlphh	..................................................................................................................................LIp+pclDIhDIslsplT-QYl.....s.....Y.......l......c......p......h.....p.........p..........h.........cL..-l...............................AuEYLVMAApLltIKS+hLLP...........p..t.p....t...p...p.......t....-.......t............................-s.....R.p.-.....L..l...p......c.L.h..-.Yc..p...a....K.th..u.....p.t.L.pp.h..t....ttt..........has.+.t......................p..p..h..h..p..t....t.............t..l.p...........p..h..c...L.h..h..A..h..tp.l...hp.+.t......p.h.pph.......................tl...s...l.cp.p.h.p....p..lh..t.....................................h........t.....t....p......hhpFp.p.L.h.p.p................................tps.t.t.t..l.l..sp..FLAlLELhKpthlpltQ.p.c..sassIhl...t.......................................................................................	0	264	526	667
+1899	PF02617	ClpS	DUF174; 	ATP-dependent Clp protease adaptor protein ClpS	Mian N, Bateman A, Moxon SJ	anon	COG2127	Family	In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins [1].	20.00	20.00	20.10	20.10	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.71	0.72	-4.26	194	2895	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	2572	47	893	1937	1064	79.80	36	28.96	CHANGED	hcps..shY+...VlLhNDDaosM-FVlplLpphF.phsp-pApplMLpVHpcGp.uls.ulhsh-lAEs+spplpphu......pttth.........PLpssh	...........h.p.PshY+VlLhNDDaTsM-FVlpVLpchF...s....hs.........h-cAsplMLpVHppG+..uls.G.l.a.o.t.E.lA.EoKstp.Vpphu........+ttta.........PLhssh.......................	1	268	550	744
+1900	PF02618	YceG	DUF175; ADC_lyase;	YceG-like family	Mian N, Bateman A, Moxon SJ	anon	COG1559	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of Swiss:P28306 was solved by X-ray crystallography.	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.01	0.70	-5.39	195	4001	2009-09-21 13:22:03	2003-04-07 12:59:11	11	7	3759	2	892	2962	1446	281.50	30	77.07	CHANGED	htlplspGsohppluppLpcpullpss........hh....F.phhs+hp..stssp.l+uGpYplpss.hostpllptL..spG........................................................csht......h.plTlsEGhshpp............lhptlsp.........pshh..tp.t......t.tp........htphst.................EGhLaP-TYpa.stss.......ospp.llpphhpphp...phl..tpthppcs...................ttl...sh.osh-hlhlASIlEKEsu.hssERshlAuVFhNRLc.p.......GM.....pLQoDPTVlYu..l...tt.......tt............plppp...DL.c.ts....oPYNTYthpGLPPsPIusPGpsulpAAlpP.spsc.....aLYFVA...c.sc..........Gs..HhFopThpEHppsV...pcY	.............................................h..lpl.tGsuhpplupp.Lpcpsl.lpss....th.....F...phh.h...+.h......p.......s......h...sp....l+uGp.Yp.l....pss.hosp.cllphL.....pp.G........................................................c.psp...........h..plslsEGh.sh.pp..........................hhptl.tp..........................tshl.......ppp..............hpp....th.h...t.t...h..tt.ph.s.ph..............................EGhhaPsTYp.h..st.....ss............o..s.p..llcphhpphp.....ptl........pph.h.t.tp.t.............t.sh.....sh.s..phlhlASllEKEs....u....h..s.p.-.RshlAuVFhNRL.p.t.......sM...........hLQoDsTVlYu..h........sc.........p............t...plppp.............Dl...c..hsoPYNT.Yh.h....sGLPPsPIssPuhsulcAuhp.....P....spo.....s.......aLY..FVA...c..ss........Gs..phFup.shp-HppsVpc................................................................................................................................................	0	308	608	762
+1902	PF02620	DUF177		Uncharacterized ACR, COG1399	Mian N, Bateman A	anon	COG1399	Family	\N	21.30	21.30	21.50	22.20	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.80	0.71	-4.06	181	3846	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	3794	0	853	2473	744	115.20	24	64.04	CHANGED	lpuplpu..slphsCsRCLpshphslphp.hphh.h..h...sppt..tt...............................--..thhh.............sstp............lDLtphlp-pllLslPhtshp.....p..sCps..hsststs..tt.........................tt.........s....P.....a.usLpsL+	....................shplpsslsl.CsRCLcP..hp.ht.lphs.hs.h..h...ht...sppp....tpt...............................................-s.psl.l............cpsp.............lDLtshlcDpllLslPhtslpp........-.....cCps.....h.s.s.s..ss..p...hsct...................................p...pp.ps.................s......P.....a.AsLtsL........................................	0	270	558	726
+1903	PF02621	VitK2_biosynth	DUF178;	Menaquinone biosynthesis	Mian N, Bateman A, Eberhardt R	anon	COG1427	Domain	This family includes two enzymes which are involved in menaquinone biosynthesis. One which catalyses the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate, and one which may be involved in the conversion of chorismate to futalosine [1]. These enzymes comprise two domains with alpha/beta structures, a large domain and a small domain. A pocket between the two domains may form the active site, a conserved histidine located within this pocket could be the catalytic base [2].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.28	0.70	-5.18	131	1044	2012-10-03 15:33:52	2003-04-07 12:59:11	9	3	556	15	368	1003	282	248.00	24	91.99	CHANGED	lplGtsshsNsh.haauL.........................ths.hchhhssspsLNphhh.puclDl..uhlSshtasphtccYtlLs..usuuhGpshuslllu..................p....t..tt.....plAlsupssTushLh+lhh.pt........phh.hs....cl..thhpst......DA.........ullIt-stl..................satppth....hhlhDLGchWpchT.G..LPhshuhhsh++s.hs.....phhtplpc.slppShphuh..pphpphhph...hhcpsthh.......pp.hlphYls.phohslupctppulcphhphutc	.......................................................hplup.shhNsh.hahul..............hpht.......ths.hc.h...h.h.ss...s...pp.LNchhh.....p..s...c..l.Dluhl....S....h....h....t..h..sp..h....h....c....c...Y.t.l.L.......ss.s..u....hG..c..sh..usl.lls..................pp....h..t...hp...........................plAls.u.....p.ssT.ushL.h+..lhhtct...................phh.hs......pl....h.hpst......DA............................ull...It...-..ptL.....................pa.t.p.p..h........phhhDLuphWp...-..h.T...u.....LP.......h.s..hu..shsh++s..h......................shhtplp.ctlppuhph.u....pp.p...hlhph....hh.cppt.hp...........pphlph.Yh..s...phsh...sl..u...p..pphtAlcphhchsh.t...................................................	0	156	292	345
+1904	PF02622	DUF179		Uncharacterized ACR, COG1678	Mian N, Bateman A	anon	COG1678	Family	\N	20.60	20.60	20.60	20.70	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.22	0.71	-4.61	181	2362	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	2224	7	628	1535	1045	160.00	35	76.37	CHANGED	hP.s..hsDspFp+oVlalC....cHsp.c.GAhGlllN+..Ph..s....lsls-llppls.........h................................ttph..............sVahG....GPV.ptc+....GF...lLHss..t............t....ts.............ol..pls...s.....slhlTsohDlLps...lupu.tu.....PpchllsLGYAGWusGQLEpEl.tpNuWLsssAssc..........llFss.s.pp...+WptAhpplG	......................................................................................................................................hPshpDshFpRSVlYlC....-Hsp..p.G.A....h.GlllN+..Ph..s......l.sl..psl..Lpplph.s..........................................thcp.....................................sVhhG......GP..l..pp-R.......GF...lLHss.tt......................h......su...................................................ol...pls.......s..sl.s.h...T...s..o.tD.lLcs....luss....tt............PpchllsLGYAuWst..GQLEpEl.tc....NuWLsss.A.c...s..........llFs....s....shtc.......+WppAhphlG.....................................	0	200	399	525
+1905	PF02623	FliW	DUF180; 	FliW protein	Lima T, Mian N, Bateman A	anon	COG1699	Family	The protein BSU35380 from Bacillus subtilis (renamed FliW) was characterised as being a flagellar assembly factor. Experimental characterisation was also carried out in Treponema pallidum (TP0658).  In Campylobacter jejuni, Cj1075 has been shown to be involved in motility and flagellin biosynthesis. The two paralogues in Helicobacter pylori (HP1154 and HP1377) were found to be able to bind to flagellin. FliW proteins are involved in flagellar assembly [4]. FliW is part of a three-part feedback loop: in Bacillus subtilis FliW inhibits CsrA (an RNA-binding protein) which inhibits FliC translation; hence FliW is required for FliC (flagellin) production [5].	25.00	25.00	31.20	29.20	24.60	23.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.40	0.71	-4.55	83	725	2009-09-10 21:46:53	2003-04-07 12:59:11	10	3	652	2	212	534	71	119.40	31	84.43	CHANGED	lpF.pGl.GF-.ph+cFhll.....ppsssFhhLQSl-ssclu..FlllsPathh.-YchclscpphptLplpstp......-lhlhsllol.....tss...hcchTsNLtAPlllNhcsphutQllL.psscYsh+a.lh	.......thppsIhGFE.ch+cahlh.........ptcpsFhhLpSl-....st...s.lu..FlllsPahhh...-Y..ch...cl...ssthhphLpl.ps..tp................c.lhlhsIlsl........sps........hccsTl..NlhAPlllNhcsphutQllL.ssspYshpa...h...................................................	0	108	182	198
+1906	PF02624	YcaO	DUF181; 	YcaO-like family	Mian N, Bateman A	anon	COG1944	Family	\N	25.00	25.00	25.40	25.00	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.89	0.70	-4.95	127	1709	2009-01-15 18:05:59	2003-04-07 12:59:11	11	25	1462	0	432	1316	83	324.50	28	58.87	CHANGED	ssGKGtottp.ApsSAlhEulERauuth.hst.................hthtpshtph......ttts..lsspshhhhsppph.....................hs.st.lp........Wh................shsltss.....c.plhl..Ptsh...httsh..................hhh..sS...NGhAuGsohcEAllpulhEllERDuhslh.....hhsp...hshspl..........shss....thstlhpthpp...tG..hclhlhDho.......-h.slPshsuhh....................hpssssthhhGhGu+hsschAltRAloE..hsQsthhhh.ttstpp.....................................p.tphtphhshsphttt..hhh...t........sphphsshs.............s.tsslptl.lstlpptGh-.lhsl.Dho......h.clG.lsVV+lllPGhp.	...............................................................................................sGKGsopcs..Ahs.SALuEhhERhusshhhs-...........................hhhtpslsst...............................shs.pass-pah..t...................................thac.P.-scls.................hs................................shhc....s...cs......p..slal..Phsl....lsshas..........................S....NGhuA....G.NohpEAhlpGL.E.lhERtshsth..................................hhpp......lslPcls.........s.shs.chss.l.hctlpph.p.t.pG..aslhshDso......h..ss..th.P.Vl.ssll....................hsssssssh...suhGAH.sDhtlALcRslTE...l...h....QuRshps...h.sshssssh....................................stcchsc..ht.shpp..p..hhcs.stlh.....t........httt.....schsas-hs............hss.ss.p.c-hssL.hsh.hppt.sh-..lhls.Dhp.........cl...G...lhssRllVPGhp........................................................................................	0	120	256	346
+1907	PF02636	Methyltransf_28	DUF185;	Putative S-adenosyl-L-methionine-dependent methyltransferase	Mian N, Bateman A, Moxon SJ, Eberhardt R	anon	COG1565	Family	This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [1,2]. In eukaryotes it plays a role in mitochondrial complex I activity [2].	23.20	23.20	23.50	24.00	23.00	22.70	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.82	0.70	-4.98	157	1692	2012-10-10 17:06:42	2003-04-07 12:59:11	12	15	1433	3	694	1556	1906	243.10	24	62.15	CHANGED	hluhhhhphapph....s...ts.......hpllEhGsGpGpLhsDlLpshp........ph.P.ph.....htt..hphhllEhS.............stL+phQpppL.................tt...................................hsh.....W..hc.pl..t..ph.s...................hsslllANEhhDAlPl+phh.................................hpsss..a.pEthVshs.......................................ss................th...ths..h.ts....................htshltphthth...............................tGhhsElsssstshhppl...upplsp....................................................GssLhlDYGh.stpp...........hssTL..puh................ppHpht.........s.sh...tpP.GptDlTAHVDFssL....tpsu.pt.G...hpshuhs	.............................................luhhhhp.hpth......t........t............hplhElGsGpGpLhtDlLptlp.........ph.s..th.....htt...hphhllEhS..........................spL.pphQpp.p..L..........ps........................................................htt.l.t.W....hp..pl..ph......................hsshlluNElhDAhPlchht......................................................................psptt.......h.hEhhVshs............................................................................ts............ph.ths.....h.tsh.t...........................tth.l..pht.th..............................................tsth....h..Els..tttthhppluptltp.....................................................GhhlhlDYGh..tst.............................psoL........puh..............................hp.Hchh......................s.sh.tts....G...ptDlTucVcFstltphs.pt.s..ht.....h............................................................................................................	0	221	439	583
+1908	PF02638	DUF187		Glycosyl hydrolase like GH101	Mian N, Bateman A	anon	COG1649	Family	\N	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.14	0.70	-5.57	4	1510	2012-10-03 05:44:19	2003-04-07 12:59:11	10	34	1000	0	288	1415	225	300.00	32	62.31	CHANGED	clRGVWlssVsslca..............spsQppphIshLcclp...hNTlaspVhssGpsLYPSthu..Wpshhssp.ttD.GhDsLu.hI-cAH+RshcVhsWF...chuhpss.....shschlcpHPthhh.p+pDhsts.....GsphahsPhhPEVQsaITpllh-lVp+YDlDGVQhDDaFh.spphG.-..s.uhYcQ.st.sshus.cD..................WRpsplsphltplstpIKAsKPslphulSPsssa.N..............huYsshhtDhpcWlcpGllD.lssQlYhs.hut.suthphhuhh.ocplhPssVtlhhGlsshpls.s..p.-ssWss	..............................................................hRuhWlsoV.....p..h..-.aP.................hpt.p....pp...t....h.l....c...h.L...c...c...lpt.....thNsVhhQV.+.P.s.usAl.asS.p.......h.........h......P.......W.............S...........p..h....h....T.......G..........p........G...p.....s..P......G......aD.P..LtFhl-EAHK.R....G.....hc.lH...A...Wh...............hch...s....h..s.sp............p.h.s..p....h..h...s...p...p..Ps......p....h.h......p.....+.....-..h.......l.....h.s..........h...................................................u..s.......p...h...h.ls...P....GlPE.V.pcalsslltEl..Vp+.Y....s....lDGl..p..hD........D......Y...F...Y..............h......p............s.....s......G.........t......p.....h...s.....D......p.....p........s...a.p.p...Y..s.......t.s..h...s.s..h..s.D....................................................W...R...RsNs.pp...l...lpclppsl.K....s...h...K....P....t.........VcFG..l.S..P.h.Gla..s.tpc...............................sptGhtsY-.p..Y..AD..sppWl....p.p....Gh...lDYlsPQlY.W....s.........h.sh.....s........u......t........ashlhpW...W..s.p..s.....t..s....p.....h......tLahG.sh.hph....................................................................................................	0	98	206	262
+1909	PF01579	DUF19		Domain of unknown function (DUF19)	Vogel B, Bashton M, Bateman A	anon	Pfam-B_402 (release 4.1)	Domain	This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins.  It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges.  The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.95	0.71	-12.01	0.71	-4.25	47	383	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	8	0	378	354	0	150.60	15	67.46	CHANGED	sCsststh.........pshpCh....h..htphtpphpthshp....ptsphpphppsCsshhpChpshpC.......tt....hp.h.thCphh.ah.stpa.pChsKlts.......ptspChpsat...........ttptpphtpcsCpthhupc.sCh...........cctl.ppsCGp...pphptatsphh...........thsshhhp.pCshp	..............................................................................pCh.....h..htph.t...tht.t......hs..t.........pthpphpphCp.....p..h.h.pChp.sh..p..C....................t..p.hp.htt...h..C.p.hh.ah.sp.p.a..t.pChp....Klts.........p...pp..sCh..psa.....................................pptt...pppptC.p.thhspp.sCh...........cptl.pphCup...pthptatpph.................................h...................................................	0	97	120	378
+1911	PF02643	DUF192		Uncharacterized ACR, COG1430	Mian N, Bateman A	anon	COG1430	Family	Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologues are also present in several Plasmodium species).  TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homologue of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homologue in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	20.30	20.30	20.70	20.50	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.23	0.72	-4.36	180	1078	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	966	4	459	1048	876	105.70	30	67.60	CHANGED	shplElAcTstpRtpGLMhRpsl..........ss...sp.GMLFsa..s.......psph.tsFWM+NThlPLDllFlspsGplhslppts......Pts..tss...h.ssh...........s.sph....VLElsuGhhpphulpsGcplph..	..................h.hplElAso.tpRtpGLM..aRpsl..............st...sp.GMLFla......s...........psph..tsaWM+NT.lPLDllFlcscGp.....lhslpc.t..........Phs.....ps.......h.sst.............................ts...spa......sLElsuGhhtchGlpsGsclp...h............................	1	129	301	397
+1912	PF02645	DegV	DUF194; 	Uncharacterised protein, DegV family COG1307	Mian N, Bateman A	anon	COG1307	Family	The structure of this protein revealed a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that this family has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism [1].	20.30	20.30	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.61	0.70	-5.33	45	5275	2012-10-02 12:41:15	2003-04-07 12:59:11	11	9	1863	22	831	3515	181	269.70	26	95.33	CHANGED	clsIlTDSousL.s..t-hhcchslpllPLslhhss.csYpDsh..-l.s.cphhcchtpptphPp.TSQPssschtchacc.hhppua-tllsltlSStLSGTapsAthusphh.....shc..........lpllDSphsuhu.GhhVhcAuchhcpGt.shc-Ilpplpphppcp..psahsVcsLchLh+GG...........RlupstuhlGsLLslKPllphcc..GplpshsKsRupK...KAlcclhc.....l..ttptsstthhclslhaus..st.-puppltcplps..phst..ch.hsthuslIusHsGsGululshhhc	.....................................................ltllTDSos.s..l.s....t..c.h.h..c.........c....h....s....l..p....l....l....PLs.lh.....ls....s.....p...s...Y...h...Dsh..................sl..s.c...ca...h.p..p..h.....p..s...p..p.h.P.p..T.....SQPshupahchacp...htp..s.h..s....p..lls.lpl..SusLSGoaps...Ap......u.s.p.h...............shp...................lpll.DS.phs.uhuhuhhlh.pA.s...c..h...h.pp..Gt....shc..-.l..l.ppl.p.p..h.pp..p.s..phah..hlss.LcpL.....h+GG...........Rlop......ssuhl...G..s...L...LsIKP..l..l.p..h..p..c...GpltshpKs....Ru.....p..K.....+..u..h..pplhc.................................hh..........p.pht.......s...t......t.....h..p...l..h......l..s.aus.....s....-tA...p....p....l....pp..p.lpp...........th.st.........pl....l..t.....h.usllusHsG.Gslulhhh..t.....................................................................................................................................	0	343	598	735
+1913	PF02646	RmuC	DUF195; 	RmuC family	Mian N, Bateman A, Moxon SJ	anon	COG1322	Family	This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures [1]	23.50	23.50	23.50	23.80	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-11.80	0.70	-5.58	23	2678	2012-10-11 20:44:43	2003-04-07 12:59:11	11	9	2619	0	607	1935	2922	298.80	31	66.14	CHANGED	pppL-thhpslcEpLp.shppplcsoacphucchtpLpcpLt.l.thp...pplup-sssLppsLp..ssKopGsWGElpLEplLEssGL.cshpYppQssl.......tsuphRPDhhl+LPssp........hLlIDuKhsLpsYpchhsAp-sspp...ptshpphhpul+tHl+slupK.Y..........lhsscT.DaslMFlPsEuhascslcpsstlhphutcppVllsoPoTLhshLpolshha+spphpcpApcItchsucLhcchsphsschpcltppLspuspshsphhsphsptptphhpphpthpttusctptphsst	..................................................................ppLpphhpslc...Ep...L...c....sh....ccp....l....p.poap....p....pu....c....p....h.psL.......pc.pl............tt............lt....p....hp..............p.......plu....p-sssLscsLp..ssKspG.sWGEl.LpplLEsu.G.hh.cshc..Yp.pQssh..................st...........sup...hpPDhll+LP.ss+........................pllIDuKhsLsuY...p+hhs......A.....p.....-.s.t.p+....................cpshppahtul+pH....l....+sLupK.tY.t........l..s..c.o.hDaslhFlPsEshattAlcps.....s..pLh..p..uhc.pp..IhlsoPoTLhshLpolssha+ptp.p...csApcIucpsupLhcchstFs-ph.s....c.luppLspAsps...acpshsphsps..t...t...s...h..lp..phEthct.usp.......t...................................	0	190	388	502
+1915	PF02649	GCHY-1	DUF198;	Type I GTP cyclohydrolase folE2	Mian N, Bateman A	anon	COG1469	Family	This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens[1]. The invariate, highly conserved glutamate residue at position 216 in Swiss:Q5F9K6 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent [2].	25.00	25.00	25.80	25.80	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.78	0.70	-5.15	121	985	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	926	5	311	797	284	258.70	36	90.12	CHANGED	hPDVQ....sptsstplsls+VGlpslchPlplpsp.....t...pshAphshhVsL...P.sp..hKGhHMSRhhclLst.hp..p.t..lsstsl....cplLpchhpph......upsAclchpFsahlc+pu.lSs.hpuhtsYslthpuphp.ts.....t.hphplplpVshoSsCPCStplScpts...................................HsQRShsplplch....sst....l.lp-LIchlEpuhS.s.lhsllKRsDEpthsctuapNPhFVEDssRclstpLppp....sp.hssaplcscshESIHsHsAhA	.........hsDlQ....ostcs.hthsIpcVGl+slchP.lplppt...................t..posuphshsVsL...s...tcpKGhHMSRhlchl-th.p....p..th.....lshs....sl....pplLpshhpph.......pupsAplcl.shsaFhc+tu.....Plos...lpuhhsY-.Vshsuphctts..........t.hchplplplsloolCPCSKcIScauA....................................HNQRuhlolpspl........sp..p......lh...lpcll-hh...EssuSs.laslLKRsDEKhVTEcAYcNP+FVEDhlRplAtpLhpp......................stlssaslcscN.ESIHsHsAaA......................	0	100	210	268
+1916	PF02650	HTH_WhiA	DUF199; 	WhiA C-terminal HTH domain	Mian N, Morningstar A, Mistry J, Bateman A	anon	COG1481	Domain	This domain is found at the C-terminus of the sporulation regulator WhiA.  It is predicted to form a DNA-binding helix-turn-helix structure [2].  The WhiA protein also contains two N-terminal domains that are distant homologues of LAGLIDADG homing endonucleases [2].	21.10	21.10	21.20	22.80	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.53	0.72	-3.59	23	1969	2012-10-04 14:01:12	2003-04-07 12:59:11	9	6	1950	1	338	1114	114	85.00	46	27.44	CHANGED	lNRlsNh-sANlpKospAuh+plcpIphIhcplG.h-tLPppLcclApLRlpas-tSLpELGchlcs....sloKSGlNHRlRKlppIAc	.....................................sNRLsNsETANLs+TlsAAh+plp.sIphIpcplG..l-sLP...-cLp....-lApLRlp+.-hSLcELG-hlss....Pl..oKSGVNHRlRKlpclAp..............	0	134	244	300
+1918	PF02655	ATP-grasp_3	DUF201; 	ATP-grasp domain	Bashton M, Bateman A	anon	COG1821	Family	No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.91	0.71	-4.37	18	304	2012-10-10 13:17:03	2003-04-07 12:59:11	9	4	195	1	172	13200	4990	163.10	22	44.85	CHANGED	suDKhcsh+tLcst..hssP........hp.tchtt..........scphllKPtsGsGupusphscstpp....................llQ-aIEGcshSVSllussccshsLslN+QhIsh...t..............htYsGshsPh.pph..ppchhphApcllcsl....GLhGhsGVDll.......ls-..ttPYllEVNPRhTso	.............................................................................................................sKhhh.hp.hL.....pph....sl..s..h.P...................................h..............t........t...............................tt..th.llK.....P.h.......s.....G...s........G.....G.....h.......s...l...t...h....h...s...s...t.t...t......h....t...........t.............................................ll....Qca..l....c.....G.....p.....s............h....S..l....s....h....l...........s...........s...........s.......p......p.....s....h....h.....l...u....h...s..c........Q...h....l..s..h........t...........................................................ht.a....s..G......s.....h.......s......s......h......p......h......sh...........pp....p....l.....h....p.....h....s.....p....p.........l........s.......p......t.....l...........GL....t.......G....h....s...G......l...D.......h.l.......................l..s..s.........tt...a..l.l..ElN..P.Rhsu..............................................................................................................................	0	52	118	149
+1919	PF02656	DUF202		Domain of unknown function (DUF202)	Bashton M, Bateman A	anon	COG2149	Family	This family consists of hypothetical proteins some of which are putative membrane proteins.  No functional information or experimental verification of function is known.  This domain is around 100 amino acids long.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.60	0.72	-3.76	197	2355	2009-01-15 18:05:59	2003-04-07 12:59:11	10	32	1062	0	920	1576	39	77.60	28	34.40	CHANGED	+stlAsERThLAWlRTululhuhuhslhp..hh..h.t............................................hsh.........hhuhshh..............hlulhhhhhu.......hhp..ahptt...pt	....................+stLAsERT...a.L.AWlRTuLuhhuhuls.lh.phs..p..s.........................................................................................................hlth.........lhuhlhs..............lluhhhh.hau.....................hhR.aht....s..........................................................................................................................................................................	0	298	582	809
+1920	PF02659	DUF204		Domain of unknown function DUF	Bashton M, Bateman A	anon	COG1971	Family	This family consists of hypothetical transmembrane proteins non of which have any known function, the aligned region is 180 amino acids long.	21.70	21.70	21.80	21.70	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.29	0.72	-3.85	162	3883	2012-10-03 02:02:08	2003-04-07 12:59:11	10	3	1582	0	728	2452	78	66.50	31	65.64	CHANGED	hS..hDAhAVuluhuhh.............php....hhhsulhhGlhpslhshlGhhlGphhu..p..hlsph..........uchlGullLlhlG	..................hShDAhAVuluh.uhh.............psp......hlhsulhhGhhphlhsh.lGh.hlG.ph.h.u..p...hl.s.ph...............sc.hluullLlhlG......................	0	276	519	622
+1921	PF02660	G3P_acyltransf	DUF205;	Glycerol-3-phosphate acyltransferase	Bashton M, Bateman A, Eberhardt R	anon	COG0344	Family	This family of enzymes catalyses the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid [1]].	21.00	21.00	25.80	25.70	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.15	0.71	-4.71	127	3881	2009-09-13 07:44:17	2003-04-07 12:59:11	10	9	3433	0	833	2498	1770	180.00	37	84.40	CHANGED	lluY.LlGSlshuhllu+hhthhDlRphG.SGNsGATNshRsh.......GtphuhlshlhDhhKGhlsl.hl....uphhhhs.hhh.....hh...................suluull.GHhaPlahpF+.....GGKGVATshGl..llslsshhsl.....lshh.lahllhhlo+.hs..........SLuSlh...uslshslhshh..........................................thsh.hhlhsh...hluh..lllh+H+pNIpRLl	...................................lluY.LlGS.Issulllu+l.h..t.h..h..DlRphG.S...........GNsGATNshRlh.......GK.t.uuh.hsllhDhhKGhlsl.hl..........s.hh.hs.h..sshhh..............hh.......................................suluA.lL.GHhaPl..Fht.FK................GGKGVATuhGs.......lls.l......s............hh....s.l...........h.hhs....sall.slhls+.hs...............SLuull.......uul.hsslhshh..............................................h.p..h...h..hh.hsh.....hluh..lllhRH+sNIpRl.....................................................................................................................................................................................	0	284	542	701
+1922	PF02675	AdoMet_dc	DUF206; AdoMetDC; 	S-adenosylmethionine decarboxylase 	Mian N, Bateman A, Moxon SJ	anon	COG1586	Family	This family contains several S-adenosylmethionine decarboxylase proteins from bacterial and archaebacterial species. S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesised as a proenzyme, which is cleaved post translationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity [1,2].	25.00	25.00	27.60	27.30	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.43	0.72	-4.15	134	1798	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	1523	19	460	1159	1636	119.90	39	60.28	CHANGED	Hllh-hass..s.chLsDtchlcphltcAsctuGATllsh.thacF...pP..........pGVoulslluE....................................SHlolHTWPEhs........aAslDVaTCGp..ssPhcA...hphlhcshpscphphpp.hpRG	......................................................................-pLhssppLpclLs-s.sphhGA.s.l..Lsl..uppca.....pP..........QGsS.s.slLlSE................................................SHIslHTaPEpp..........hAsIDV.TCGs...lsPhcA.....lsYLhcpL.cuc.hsshch.hsRG........................	0	183	309	389
+1923	PF02676	TYW3	DUF207; 	Methyltransferase TYW3	Mian N, Bateman A, Wood V, Mistry J	anon	COG1590	Family	The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis [1].  yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA.  TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner [1].	20.50	20.50	21.00	20.70	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.47	0.71	-5.20	42	374	2009-01-15 18:05:59	2003-04-07 12:59:11	9	24	292	11	258	380	11	199.60	29	62.09	CHANGED	cppKpphLpclt..........-tp.cGplDcsIhsllchIN...uhpshhTTSSCSGRIoVh.p....................tp.hp+.......................tsupWLahsHcs...................hphpplhcslptshsst.....................lhh+hcP.ILHVhs+sLcpAptlhshAhssGF+cSGItshp...................pphlVtlRss.h+l-sPluhps...............chlV.sc-YLphLlcluNc+hpcspc+lpRLppslcp..hhp	.................................tKtphLppl...........DhS.+GplDtslhsllphlN...sh.tshhTTSS....C.uGRlslhtps.............................t...tc.............................................................................tsupWLhhsH.c.............................................................hp.pphhphhph..ttttt..........................................................lhh+hEPh........ILHVhspshppAphLhps.A.h.s.uGF+p....SGltshp................................................tphhVulRss...htL-sPluhps.........................phhV..sc-Ylph....Llp....l...uNp+hpcNpc+hp+hhptlpt...t........................................................	1	79	129	198
+1924	PF02677	DUF208		Uncharacterized BCR, COG1636	Mian N, Bateman A	anon	COG1636	Family	\N	21.10	21.10	21.10	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.35	0.71	-4.49	75	1642	2009-09-12 22:47:58	2003-04-07 12:59:11	9	4	1534	0	279	1063	255	165.00	42	73.24	CHANGED	lLLHsCCAPCSsaslctLppp..shclosaFYNPNIHPhpEYhhRhp-sc+hspch......slphltu-..Y-...hcpahctsc..GhEp-sEtGt.RCthCachRL-poAphApEtGFchFoooLhhS.aKshpplpchGcchupca.slpahhpDaRKtsGhpcslc.......luKchslYRQpYCGClaShc-p	..............................lLlHsCCAPCSs.shEhLpp....h-hslaFaNPNIHPhpEYhhRtpppt+Fscch...................sl..t..hl-.u-..Y-....c.pahcts+.....Gh.E..pEsE.t....G.hRCphCF-hRh-psAphAh.......E.......tG.......achFoosLslS.hKshp.pINphGhcssph........Y......s..............lpYhs.sa+KssGhpRtlE.......hs+c.phY+QpYCGClauhpp.p............................	0	102	190	241
+1925	PF02678	Pirin	DUF209;	Pirin	Mian N, Bateman A, Moxon SJ, Yeats C	anon	COG1741	Family	This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function of Pirin is unknown but the gene coding for this protein is known to be expressed in all tissues in the human body although it is expressed most strongly in the liver and heart. Pirin is known to be a nuclear protein, exclusively localised within the nucleoplasma and predominantly concentrated within dot-like subnuclear structures [1]. A tomato homologue of human Pirin has been found to be induced during programmed cell death [2]. Human Pirin interacts with Bcl-3 and NFI [3] and hence is probably involved in the regulation of DNA transcription and replication. It appears to be an Fe(II)-containing member of the Cupin superfamily.	26.10	26.10	26.50	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.44	0.72	-4.17	52	4965	2012-10-10 13:59:34	2003-04-07 12:59:11	11	18	2388	5	1562	3896	1851	109.40	35	40.71	CHANGED	shclpcshst.........shhphhsPFlhhDphsPspht.u............shuh.ssHPHpGhETVTYlh...cG.clpHcDShGscuhlpPG-VphMTAGpGIhHSEhs.st...........stsh+GhQlWl	.............................................................s....tp.hut.....shhps.hpsF.Fh..-a.a..sPp..ths.us............................-.h....stGF.ssHPH+shEh.l..Tall........c...G.pl.p...Hc..DS.h...Gs.......p.s..............h.............l...p.sG.-......lQhMoAG....s....GIh....H.SEhsssp........................spslchhQlWl...........................................	0	450	941	1293
+1926	PF01595	DUF21		Domain of unknown function DUF21	Bashton M, Bateman A	anon	Pfam-B_618 (release 4.1)	Family	This transmembrane region has no known function.  Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Swiss:Q54318 that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains Pfam:PF00571.	25.10	25.10	25.20	25.10	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.93	0.71	-4.99	126	9166	2009-01-15 18:05:59	2003-04-07 12:59:11	15	26	4552	0	2462	6747	2342	186.30	24	42.42	CHANGED	hhllhlhlL.lhluuhFuusEhAlhulspsclcpht....cp..ss.....ptApt.lhplhpp......sphLsslll...Gsslsslhhu.slushh...hhphhs...................huh.hluhllhThlhl..lhGEllPKsluh.p..tsppluhhhuhhlthhhhlhh.Plshllshhs.phlhphhshp.........t.hhop.cElctllp.up.ppG....slc..pcE	..................................h..llllhlLlhlsu.aFu.uuEhAlhulp+s+lc.p.hs.........cp.....Gs.....................ppApt....lh...cl...h...p.p..........sphLosl..l................Gh.slsslhhu..hlupsh.......htp..hhts..................................huh.hluh.sl.lThlh.l........lhuE......lh..PK.slAh..p..ts-pluh...hhuh..slthh.h...hl..ht..P..l...lal.ls.ths.sh.l....h+.h.hshp..............ptth..oc...-E....l.c.tllptut.ptG.lpt..........................................	0	785	1593	2105
+1927	PF02679	ComA	DUF210;	(2R)-phospho-3-sulfolactate synthase (ComA)	Mian N, Bateman A	anon	COG1809	Family	In methanobacteria (2R)-phospho-3-sulfolactate synthase (ComA) catalyses the first step of the biosynthesis of coenzyme M from phosphoenolpyruvate (P-enolpyruvate). This novel enzyme catalyses the stereospecific Michael addition of sulfite to P-enolpyruvate, forming L-2-phospho-3-sulfolactate (PSL). It is suggested that the ComA-catalysed reaction is analogous to those reactions catalysed by beta-elimination enzymes that proceed through an enolate intermediate [1].	25.00	25.00	30.60	39.00	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.55	0.70	-5.36	30	234	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	207	2	133	248	145	238.90	32	79.40	CHANGED	hthspRsp..K.PRppGlThllDKG...luhpthcDhLcsuupYIDhlKhGaGTuslhspchl+-Klclh+caslhsasGGTLhElhhh..psph.-cYlcps+clGFsslElSsGolclsp-c+tch....IcpspctGhpVhoEVG.....................pKcsppptp.psschlchhpp-L-AGAphVIlEuRESGps.Glacss...Gpl+sshlpcllpp.ls..hc+llFEAPpK.....ppQthhIpchGssVNLuNIs.p-llsLEsLRtGLRGD	.............t..stRstK.PRppGlT.lhD.u.........................huhphhcDl.lc........s......sGpalDhlKhuhGotslhspp.l+-tlclh+paslhlhsGGhhhElhht....ps.p...h...ccYlcts+clGFcslElSsGsl.slsp-cphch....Icphp.ptGhp.shsElG......................pKs.ptths.pstchlchhcppL.-.A.GAphlhlEuc......Glhcss...uphRp-llppll.pp.ls...hc+lhFEAspp........ptptaaIccaGssVNLsNls.scllsLEsLRhGLhus......................	0	56	91	118
+1928	PF02680	DUF211		Uncharacterized ArCR, COG1888	Mian N, Bateman A	anon	COG1888	Family	\N	20.90	20.90	20.90	50.20	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.03	0.72	-4.18	22	122	2009-09-13 14:06:05	2003-04-07 12:59:11	9	1	121	29	80	118	3	93.30	43	97.60	CHANGED	M...s..lRRlVLDVLKP.+pPsll-lAtpLuclcGV-GVNIoVhElDpcTpslplTIEGsslDa-pIcchIEphGusIHSIDEVsuGcpllEp.cssQ-	........slRRlVLDVLKP.+pPsll-lAppLuclcGV-GVNIoVhElDh-TpslplsIEGssl-a-clpcsIEchGusIHSIDEVsuGc+llEt..................	1	19	41	62
+1929	PF02681	DUF212		Divergent PAP2 family	Mian N, Bateman A, Yeats C	anon	COG1963	Family	This family is related to the Pfam:PF01569 family (personal obs: C Yeats).	21.70	21.70	21.80	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.64	0.71	-4.46	40	730	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	571	0	233	576	175	132.70	41	83.60	CHANGED	lhsNtsLhsAllAhhlAQhlKlhlphhhp...++hch.......phlhsTGGMPSSHSAhVoALuTulGlppGasSshFAlAslFAlIVMYDAuGVRRuAGhQAclLNp.Llp-h.p.............t..tpcpLKELLGHTPlEVhsGulLGlhlu	...........................hpN.sLhuulluhhhAQhlKhhhp.h....htp.....p.+.h.ch.......phhhuoGGMPSSHSAsVoALuoulGl....ppGhsSshFAlAslFAhIVMYDAsGVRptuGcQAplLNp..l...h..pph.pth............................tpcpL+El.lGHoPhpVhsGullGlll...........................................	0	86	168	208
+1932	PF02697	DUF217		Uncharacterized ACR, COG1753	Mian N, Bateman A, Eberhardt R	anon	COG1753	Family	Structural modelling suggests this domain may bind nucleic acids [1].	25.10	25.10	25.20	25.10	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.55	0.72	-3.73	16	123	2009-09-10 16:57:48	2003-04-07 12:59:11	9	1	63	0	61	129	9	67.10	27	87.20	CHANGED	sKTIoIsD-VYccLlchK..tscSFS-VIpcLlc.......spcctLhchaGhls---h.cEhc+clpEs.tphcc+h	..........KTIslo--sYccLpchK.pssESFS-lltRLlp.......tpt...cplhch...h..Gh....h...s-c..-h...cchtcphcc............................................	0	9	40	54
+1933	PF02698	DUF218		DUF218 domain	Mian N, Bateman A	anon	COG1434	Family	This large family of proteins contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The family includes   SanA Swiss:P33017 that is involved in Vancomycin resistance [1]. This protein may be involved in murein synthesis [2].	24.30	24.30	24.30	24.30	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.02	0.71	-4.73	148	7246	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	3217	2	1345	4642	908	154.40	20	61.35	CHANGED	pscs.llVLG.........th..stt..sh..stp.Rl.ptulcLhc....t.shssh......lllS.....Gu.s.t......................hsEAphh......pchhhpt.G..ls.....tpplhh....-sp.ups...ThcNA..thst.plhp.ppsh.........t...ph.l.lVTsshHhhR.......Ah...hhhcptuh.pshshsssh.ssht................................................phhh+E.hhu....h	....................................................................................ph.llVLG...............th...s.t......s.h........htt.Rl.stA.....h....plac.............p..s..s....sh...............lllS.....GGputs...........................shsEA...psh.............tchh.hp..t..G.......ls......................tp.p.Ilh.....-.sp.ut.s....Th-Nhhhuc..plhp...pp...................................ph..l..lVTssaHh.R........Ah..........hhh....p......p..h..Gl..p...s.......s..hs..s.s..........................................................h..................................................................	0	387	838	1133
+1934	PF01629	DUF22		Domain of unknown function DUF22	Bateman A	anon	Pfam-B_1137 (release 4.1)	Family	This domain is found in 1 to 3 copies in archaebacterial proteins.  The function of the domain is unknown. This family appears to be expanded in Archaeoglobus fulgidus.	25.00	25.00	73.10	70.50	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.04	0.71	-4.58	23	49	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	29	\N	41	51	0	107.70	28	79.39	CHANGED	hp.c....hphshchsGclh+cc..lchcsauYp.pup.lupWEslIAsEcl-VccGEshhl+I+clclPssTllhPhslhRHAhGsllDVspps.PtpVE-c+plscAlFlsscDG	................ht.............htscltchc..lctp.hsap..htp..huphcsllAsEcl-l+pG-hc.I+I+cIplPspollhPsshhpHslGpllslscct.Ph.lEp-RplcpAhFlsstDG..	0	20	30	37
+1935	PF02713	DUF220		Domain of unknown function DUF220	Basthon M, Bateman A	anon	Pfam-B_1412 (release 5.5)	Family	This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned  region contains two cysteine residues.	29.40	29.40	30.70	44.10	28.10	27.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.70	0.72	-4.30	17	83	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	13	0	48	82	0	69.60	52	24.65	CHANGED	hSGslPIpLllcEN+Ksho..uKYKKcKMMFMKlFEGsWKVEPLYVDs-RLCKppcPKShEEY++CSGGpG+IuSK	........................SGslPlplll-EN+Ksho............sKYKp.pKhhFMKsFEGsWKVEPLYVDpERLC+.....shcPKShEEY+pCSGGpG+IuSK.............	0	21	27	30
+1936	PF02714	DUF221		Domain of unknown function DUF221	Bashton M, Bateman A	anon	Pfam-B_1596 (release 5.5)	Family	This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.	28.70	28.70	28.70	29.20	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.88	0.70	-5.57	82	1418	2012-10-02 00:51:22	2003-04-07 12:59:11	10	55	296	0	1031	1387	24	296.20	22	36.12	CHANGED	uFlpFcophsAphssQ....................shtppps...hph..hsthuspPcDllWpNl.slshhp+hh+phhsshhlhhlllhaslPVuhl.uhlsslstLsphhPhLphl...t...hs.hhh.ullsGlLPslhLslhhhllPhlhchhuphpGhhopuphEhpshsp......hFhFhllplFLlsol.uuoshsh...lpplls.............pssslsphLApsL..P......ptusFalsYlllpulshsuhpLLplssLlhhhlhtthhs......pTPRchhpth.s.sshsaGshaPhhhhlhsIslsYo...lluP..lILsFuhlhFhlsahsa+YplhYlas.pph.-ot...Gtha..PhshtplhhGlhlhplhhhGlh	...............................................................uFVpFpsthtAthshp..........................................shtp..p.s......hph....hthAspPpDlhW......pNl....tls.hh..p...h.hh...R....phh..h.......h..h.l.hh.l.h.....h...h....a..s.....hPs.sh.l..ss......l.....s........p........l......s......hl...........pp..h......h......s...h....lp.l...........................hhh...s...h...lpuhLPsl.h.L.hl.h...h..l.l.P......hl..h.hh....hu.t.h.p.G.h.h..otothchtshpp......hah..Fh......l..h.p....lhll.s.sl.sussh.sh.......htthhp.........................................ts.p.p.h......p.hl.u.t.sl....P.........ptusF.a.ls.....Yl..lhpuhhs..h.uh..p.Ll.....pl..s.s....Llhhh...h.....h..t..h..hht...........posc.....c.....h..h.......th.......h.............p.....t....hp....au......t......hhs.h....hhhh...........h.............h.....l................s.....l..sYu...hlsP..lll..sF....shlhhhltahsh+aplha..........sh...tph..-st..........G.t.ha.....shhh..t..ph..hhulhlhplhhhGh..............................................................................................................................	0	345	611	869
+1937	PF02720	DUF222		Domain of unknown function (DUF222)	Mian N, Bateman A	anon	Pfam-B_1711 (release 5.5)	Family	This family is often found associated to the N-terminus of the HNH endonuclease domain Pfam:PF01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family [1].	24.40	24.40	24.60	24.40	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.74	0.70	-5.29	29	2037	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	207	0	557	1830	116	259.90	21	64.47	CHANGED	thutlt-hpsttcpLsuhtthlhscl.....spcsh.tttGsculushlAsphplStupAspplphAtpLtpR...........LPtsAsAhtpGclshcpVpsItttscplscshslssh-tApsshlppusp..hpscpLtthscphhthh...-...............................PDush.....sct-ttc.......cRtlslus..ts-GMoplpGhLsscsuAsh-shLsphAus.hCss..................DsRossQRptDAlsAll....RhshssGphsp.sGh..........sslllpsshpchpssust............slsGhGslLPhp-lhcLApcAp..Lt.lh.t.hupPls.hs+spRhsSss.RhhLhsRD	............................................................................................................................h...........h.tth.sh...........h.....h.ph.....................ttts.......t....s.h......p.......h..s.t..l.u..t..h.t.h.o...........s.tAt..p...hh.....t......A.........t...s..L.h......................................................hst.stts.......htt...Gtl......s.t.phthlhth.......h.......t...........l...............t............s..............h...........t.....h..........h.......p..t....t...........s....t..........h.....t.t.h..t.......hps..tp...l.....t.thh.p.thhthh.....c...............................................................................................................s..c..u...............pttc.ttp................pRtl.ph.....t..t...t.....-.Gh.stlp........u.h.Ls.st...tt.sthp..shl..sthu......ts...hsss......................................................................................................D.sR.o.s.Q.p.....p.t.D.uhhthh...................................phhht...s.s...t....s....p...t.uh...........................................st.lh..l..p..h.s.....h.p.p..hthtss.................................................hhhs...hs...lsht..h.h.p....h........s.t....p........ut..........ht..............................s......s.....h......h.......c.....thh.s.t.t.hl.hpD............................................................................................................	1	124	377	513
+1938	PF02721	DUF223		Domain of unknown function DUF223	Mian N, Bateman A	anon	Pfam-B_1714 (release 5.5)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-10.03	0.72	-3.90	15	441	2012-10-03 20:18:02	2003-04-07 12:59:11	9	27	17	0	209	461	0	88.80	23	26.26	CHANGED	sLlLsDcpG......splcATIsp+hushYt.........-plp..EspWcsIooFsVp.sssulR...sTsHca+IhFhcp..........ThVspusshpssh.ahshTPFDhIl--osspslL	.......................hlLhDcpG.......spIpAsl.p.p.phh.sp.ap.........shlp..EsphhplpsF.p.Vstss.sth..R...sosHca+ltFhts..........Th.lpt...s...psh.s..s........hh..p..hs.Fs.lhtt.....................................	0	3	13	25
+1940	PF02890	DUF226		Borrelia family of unknown function DUF226	Bateman A	anon	Pfam-B_1255 (release 6.0)	Family	This family of proteins are found in Borrelia.  The proteins are about 190 amino acids long and have no known function.	25.00	25.00	25.20	25.20	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.84	0.71	-4.41	21	456	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	31	0	21	314	0	133.60	48	76.35	CHANGED	lapFt.spsKcp+hhlhF+plaNpp+.hpthpLFPl+E..sDKFLGIaYGY+K.h.Kshhl+Yp...stspKsY.shsKsYYIEFRFKKGSVFCYl+ultpLL+.K-KhsTpY.ptLlcplhcLE+cVYcFYsKKLss..tGlIhKWIpK.NQ	............................hhpFt.sppKcpcFhlohRsLF.N...tc+.hpthpLas.l.KE..sDK.FlGIaYGa+K.h.Ks..h...hlKYp...sssp..KsY.sls.KsYYhEFRFKpGSVFCYl+uLhpLL+.Kc+tsscY.psLhshhpcLEppVYcFYsKKhsc..tG..hlhKWIhK.N.............................	0	20	20	20
+1941	PF02989	DUF228		Lyme disease proteins of unknown function	Griffiths-Jones SR	anon	Pfam-B_1298 (release 6.4)	Family	\N	25.00	25.00	41.60	41.40	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.23	0.71	-4.72	7	322	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	26	0	26	250	0	188.30	51	91.81	CHANGED	Mu-hsplccpa...cKhtclpthh...Kssppssu.ltNSl......cF+DcNl.a.spGGspoSptDKlENa...PhpuasYKRGVKLs...spsspl....plEsGGGsDLYGlClDlDEFS+TATVlPITNNFEGYLlsK...ssolKscDKL.hNpcG.LEKssGu....tssINAlALScAhpls...................pDlall+VtlFGN+ulpc	.............................................u-psplccpa...cKlsElcslh...Kssppssu.llpNSl......cF+DKNlhasspuGspoSptDKIENY...PspuaPYKRGVKLl.....sppspl.......pVEs..GGssDLYGIClDlDEFSpTATVlPITN.NFEGYLlsK...ssolKsGDKLshNppGsLEKssGu....tssINAhALScuh.pls....................p-l.ll+VulFGN+ulc.................	0	17	17	17
+1942	PF03003	DUF230		Poxvirus proteins of unknown function	Griffiths-Jones SR	anon	Pfam-B_1300 (release 6.4)	Family	\N	20.40	20.40	22.30	21.10	18.90	17.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.29	0.71	-4.60	41	207	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	61	0	0	168	0	126.70	31	43.33	CHANGED	IhsaCpppps...sppChClaPs...pshlphucchhtP+hCWhc.C...p+sspaLlpspcpphupCplssCsIslssLpl..supsclpssCt....sstshhsshspschlppphphsh......lhs.hhhhl....slhllhhl	...lhsaCsppps...sppCtCshPs...pshlppu.+hh..t..P+hCWhccCs..s+sspaLhtspcpshupCplssCs.....IslssLslt.supsclpssCs....psptsssss.p.tsc.h.lppphp.hsh......hhh..hlhhl....slhllahh................................................	1	0	0	0
+1943	PF03008	DUF234		Archaea bacterial proteins of unknown function	Griffiths-Jones SR	anon	Pfam-B_1430 (release 6.4)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.59	0.72	-3.88	91	702	2012-10-11 20:44:43	2003-04-07 12:59:11	9	11	463	0	243	706	46	99.90	25	24.52	CHANGED	WFRFlhPshsh.lEhGphc.hh.cplp..pph.spYhGhhFEcls+..-hLh.ch.t.t.h.....hsclG.+WW........c.....+sp..EIDllAlscppt....hlhsEsKWps.............ttcs+pl	..............................WFpFlhPst..sh.l-hsp.hc.lh...phl..c....pph.sp.a.huhsFEpls+..-hlh.ch.t..........hsp.lG.pW..W.......................c..........+pt....EIDlluh..scp...p..........hlhuEsKaps............p..................................................	0	80	141	188
+1944	PF03057	DUF236		Protein of unknown function	Griffiths-Jones SR	anon	Pfam-B_488 (release 6.4)	Family	This family represents the C-terminal region of a number of C. elegans proteins of unknown function.	21.20	21.20	21.50	21.80	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.83	0.71	-4.22	8	173	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	9	0	167	116	0	106.80	37	73.74	CHANGED	K...............................................suhAuTHDPNYQTLAGLssNVFpcKsG....ssuAGGuuPsAPA.tsuKPGMAATHDPNYQTLAGLsN.slFc..KKD.Gut.......sAuGsuuPtsP.s-psuKAAT+DPNYQTLAGlsNDlF.............................................................s	.......................................................................................................t....s.t.DPNYQThsulss.s....hh..ttt.........ss....ss........s...s......Pt..s...ss...............ss.t.......hAuTpDP.....NYQTLAGlss..s....lFt.....cK.s..ttt.......................ssuu.ss.sPtsP..ststhAuTpDP.NYQTLAulss.shF..............................................................t................................	0	64	91	167
+1945	PF03072	DUF237		MG032/MG096/MG288 family 1	Mifsud W	anon	Pfam-B_2298 (release 6.4)	Family	This family consists entirely of mycoplasmal proteins. Their function is unknown. Another related family, Pfam:PF03086, also consists entirely of mycoplasmal proteins of the MG032/MG096/MG288 family. Some proteins, such as Swiss:P75072, are included in both families, but of course differ in the aligned residues.	25.00	25.00	149.50	147.70	21.90	18.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.75	0.71	-4.27	14	35	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	4	0	14	29	0	135.50	36	26.32	CHANGED	LRtpLsphushpLs.lp..plplpsp.sss..........slpWNcphsshchppspPYcFpFElshcYpGsYslphathhhs...huuIPupWpGchplpahlDGclspahss+.DYPuohFpFs-..scLLFs.HlhQcIpVps	LRtpLsppuslpLs.lp..plplpsp.sss....h.....sIpWNcchsshchppspPYpFpFElshcYpGsYslphathhhs...hGuIPupW+GchplpahlDGclssWhssK.DYPGohFpFs-..scLLFs.HlhQ+Isspt..	0	11	11	11
+1947	PF01638	HxlR	DUF24;	HxlR-like helix-turn-helix	Bateman A	anon	Pfam-B_1509 (release 4.1)	Family	HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.94	0.72	-4.35	14	8192	2012-10-04 14:01:12	2003-04-07 12:59:11	12	15	2896	25	2341	7312	707	89.20	34	69.10	CHANGED	llGuKWphLILhpLhp.Gs+RFsElc+tlPsIop+hLoppLRELEp-GllpRpVYsplPP+VEYSLT-hGcsLpPlltthpcWGppahpt..	......................................lus+W.p.h.l...Il.h..p..L..............h........p.....G............s........p...R.......F.....s..-..L.p.+.p.l.......s......u.......l.....o.............p+.hLop.....p.....L+cLEpcG..l.l..p..R....p..s....a...s..p....s..P....P..+..V....E..Y.s.L.T.c.h.G.c.s...L.t.s....l.....l.p....slt.p.Wucpah...hh.................................	0	770	1605	2009
+1948	PF03086	DUF240		MG032/MG096/MG288 family 2	Mifsud W	anon	Pfam-B_2385 (release 6.4)	Family	This family consists entirely of mycoplasmal proteins. Their function is unknown. Another related family, Pfam:PF03072, also consists entirely of mycoplasmal proteins of the MG032/MG096/MG288 family. Some proteins, such as Swiss:P75072, are included in both families, but of course differ in the aligned residues.	25.00	25.00	135.40	135.40	22.70	22.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.59	0.71	-4.47	13	35	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	4	0	14	32	0	120.10	40	22.97	CHANGED	hsFpssYhsssssl.sLsFsLphpTsNFusLp-Lp-oFsp.sGssLssQLFaKssVsKLsh.ssNDLTplApTslu-shhshplsLscSIl....phsLppscpcF-ccllpPFhpcRpcAKtta-	.hsFcssYhsssspl.sLsFuLphpTsNFosLp-Lp-SFsp.sGssLssQLFaKssVsKLsh.ssNDLTplApTAlG-slhshplsLscSIl..cssLpp.scppF-pchlsPFhpcRpcAKtta-.	0	11	11	11
+1949	PF03112	DUF244		Uncharacterized protein family (ORF7) DUF	Mifsud W	anon	Pfam-B_2667 (release 6.5)	Family	Several members of this family are Borrelia burgdorferi plasmid proteins of uncharacterized function.	20.70	20.70	21.30	20.70	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.91	0.71	-4.69	7	158	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	30	0	10	164	1	148.00	70	39.00	CHANGED	hEl.plpppIhps.thphh...NhD.pshhphlc-hV.pSDFYpsGlEFDWhsEFVEYV-ClDLEI+s-psAhNLEpsLhEIpsLpsELNKIQ....NEN+K+....EKPIKDlLKh+IscIhpcasLIsplNY+FccFVFshDPpKRAIoDRFKuLhPhSu+l.a.ss	......................hElhNL+KDIaSNYR--YLMAHNFNpDTFIKLV...E...DLVE..RSDFYSSGVEFDWAREFlEYVDCsDLEIKDsQSAENLAhDLMEIDSLpKELN+IQ....NENKKR......EKPIKDhLKMhIaNITNpYPLIE..plNYKFtEFVFTLDPKKRAISDRLKGLLPTSGsVFFPSN......	0	8	8	8
+1950	PF03136	Pup_ligase	DUF245; Proteosome_20S;	Pup-ligase protein	Mifsud W, Bateman A	anon	Pfam-B_3042 (release 6.5)	Family	Pupylation is a novel protein modification system found in some bacteria [1]. This family of proteins are the enzyme that can conjugate proteins of the Pup family to lysine residues in target proteins marking them for degradation. The archetypal protein in this family is PafA (proteasome accessory factor) from Mycobacterium tuberculosis [2]. It has been suggested that these proteins are related to gamma-glutamyl-cysteine synthetases [1].	25.00	25.00	45.70	34.20	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.53	0.70	-5.88	31	731	2012-10-02 17:21:26	2003-04-07 12:59:11	10	3	352	0	214	642	154	443.10	44	90.47	CHANGED	+RlhGhETEYGIsssspsssssl..o.p.l.......................hh..at.EsPhcDARs..hclpth.stssup...s................................NlhLsNGuRlYlD....tuH..........PEYSoPEsssst-hVhaD+AG-clhppAspcApph.ut...........sslhLaKNNsDucG.sSYGsHENY.....................................................................................................................LhsRsssF.splsctLhPFhVoRQllsGAGRVG........hs.suppsu...FQlSQRADalcptVuhpT.ThsRPIINTRD..............EPHADs-+YRRLHVIlGDuNMSEhoshLKlGoTuLVLphIE....sGh.....hs-Lsl..........csPVpul+plSHDh.oLptplpLtsG+phTAL-lQppYh-pstpalppc.s..........sspspcVLshWpcsLstlcsssh...........psusclDWlsKhpLl-pa+pR........puLshsc...P+LthlDLpYpDlcsp+GLaptLhp+GphcRLls-pclppAsspPPpsTRAhhRGchlcphs...pcl.......hsAsWsplhl	............................................pRIhGlETEYGloss.......s...stpsl..............................................................sP..csARt..hhhphs..uts.us....................................................................NlhLsNGARLYlD....tuH..........PEYuoPEssssh-hVhaD+AGEplhcshstcAp.pp...hut...........sslhLaKNNsDu.................t.G.sSYGsHENY.....................................................................................................................Lhs.Rps..........s....F.splscsLlPFLVTRQllsGAG+Vs...................................ps...u...c..tss..........FplSQRADal.ptVu.tT.ThsRPIINTRD..............EPHADu-+YRRLHVIlGDuNhuEsoThLKlGoTsLVLchIE...........sGss............hpDlsL...........ssPlpAl+plS+Dh.o...h.ct.l.pL....s...........s....G........R.p.....h..o..ALplQccYhp+s.tcalpp+t..........................sspsppVl.chWs.csL-sl-.sssh.............phusclDWshKhcLlctappR................pshshss......P+lttl..D...LpYpDl+.s.+G..Las.....tL.t+Gt..hcRl.ss..-ppl.tcAsspPPpsTRAhhRGchlppht....scs.......hsssWsplhh....................................	0	66	156	198
+1952	PF03158	DUF249		Multigene family 530 protein	Mifsud W	anon	Pfam-B_2304 (release 6.5)	Family	Members of this family are multigene family 530 proteins from African swine fever viruses. These proteins may be involved in promoting survival of infected macrophages [1].	23.10	23.10	23.20	24.90	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.42	0.71	-4.77	9	88	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	11	0	3	75	0	189.60	43	38.18	CHANGED	GALEucpYDL...IpKYasQIpDhHcILPLIQDPchFE.....KCH-Lsp.Csh.CLlpHAlKasMLsILQKa+cpLstc...hhsQhLFEhACcpp+a-llpWI..utsLplYp.pslFsIAhs++DloLaoLGYpLlhs+h.sp......p.shs.LLo.pHLcpAutKGLLcFhLETLKYGGsls...hlLopAlpYsHRKILsYFl+p	.....................GALcucpYDL...IpKYasQItDhHpILPLIQDPchFE.....KCH-Lsh.CshpCLlpHAlKaNMLsILpKa+-pLp.tp...hhsQhLFElACcpp+h-llpWI..upsLtlhc.cslFsIAhsp+DloL..aoLGYpllhsph.sp......p.shhsLLs.pHLchAutKGLL.FhLETLKaGGslc...hlLotAlpYNHRKILsaFl+p..............................................	0	3	3	3
+1953	PF03151	TPT	DUF250; 	Triose-phosphate Transporter family	Mifsud W, Bateman A	anon	Pfam-B_3234 (release 6.5)	Family	This family includes transporters with a specificity for triose phosphate [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.80	0.71	-4.57	62	2906	2012-10-02 19:55:49	2003-04-07 12:59:11	11	51	371	0	1969	5343	564	144.50	19	38.47	CHANGED	Ghlhshh.ushshulp.shsphlhpc.............................................tthsshphhhhhu.hushhhlss.hhhh-thp..h.........................h.hhhhhllhsulhhahhshusahlltpsSslohsVsushKpsllllhullhFp...sp.lohhshlGhslulhGhhhYsh	..............................................................................................................................................................................................................................Ghhhshh.us.hhtuhp.lhs.p.hhh.p.p..........................................................................................................................................hp.h.ssh.s.h..h..h...h....h.u....s.h...s.....h.h.....h.h.........h.sh.....h.....h..h......h...-..t..h..t....hhh.th...........................................................................th..hhhl..h.hs.u.l.h.u..a......h.h.s.h....s.s.a..h....h....l..t...t.s.....S...s.l...Th.s.l...sGsh...Kp..hh............s.lh...hu.hlhat...............s...ho..h.h....s....h..lGhsl.s.lhG.hhhYs.............................................	0	634	1165	1620
+1954	PF03159	XRN_N	DUF251; 	XRN 5'-3' exonuclease N-terminus	Mifsud W, Moxon SJ	anon	Pfam-B_2349 (release 6.5)	Family	This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus [3].	22.90	22.90	24.00	23.10	22.80	21.50	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.75	0.70	-4.98	17	896	2012-10-03 20:43:45	2003-04-07 12:59:11	13	24	311	10	593	928	242	207.90	41	22.33	CHANGED	MGVPtFFRWLSc+YPpllpslhEcp.......................EFDNLYLDMNGIlHsCoHPpDc..shshsE-E.....hahtlFcYlD+lashlRPRKLLahAlDGVAPRAKMNQQRuRRFRuA+-Apctptctpchtcph.pp.........................................cpFDSNsITPGT.FMspLupsL+YaIpp............................KlssDstWp.slclIlSsssVPGEGEHKIM-aIRpp+u.pPsaDPNT+HClYGLDADLIMLGLuTHEs....HFslLRE-l	.......................................................................MGlPthaRWlsp...+YPt..h.........h.....c...pp...............................................................................................-hDN...LYLDMNGIlHs.C......s.Hspsp...............h..h.s--c......................h..h.ht.lFp..Yl-cl.h.p.h.l.+.P+....+l..ha...........hA...........l.................D..GV...............APR.A.KMNQ.QR.uRR..F.R.uup-s.t..pt......t.pt...p..t..p....h....t........................................................................................................................................ptaDSNs....ITP............GT.FMs..pLsptLca.a.lt...............................+.l....s.p......D..s.t......W.p....tl.p.ll.lSstps.........PGEGEHKI...Mc......aI......R....p....p+s......p...........ss.........a....s................P.Ns...cH..........slaGh............D...ADL.....IMLuL.s.....o.....H.-s.....pFplLREp................................................................	0	247	365	514
+1955	PF03162	Y_phosphatase2	DUF252; 	Tyrosine phosphatase family	Mifsud W, Yeats C	anon	Pfam-B_3756 (release 6.5)	Family	This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.93	0.71	-4.88	8	714	2012-10-02 20:12:17	2003-04-07 12:59:11	8	10	280	4	416	1012	121	149.50	27	62.75	CHANGED	llPPhNFSsVts...slYRSuaPpstNFsFLcs.L+L+oIlhLssEshsp-sLp..Fh-sppIchaalthsus+c.............hlslhscplpcsLcllLspcNaPlLlHCscG+HRTGlVIGCLR.KLppWslsuIhsEYppFous.ttchh-ppFIEhFssslhhcpss.tsthshtp	..............................................................................................................sP.NFuhVps...slYRS.u.h...P...p.....h..s...a....s...F..Lpp...Lp...L+o.llhLs....s......c...................s...p......p..............hp......Fhp.p.ps....I.p...h...h....p...h....t........h.p.s...p...pp........................................................................l.sp..p.t...l..h...psL.c.l.l...l....s......p.s..a...P..lLlHC.ppGp.cR.T.G.sl.l.u..s.h....R.+.l.Q.tWs....h.sul.hpE....Yp..p...asts.......p....s.palc.ap.p...............hh....................................................	0	143	269	372
+1956	PF03190	Thioredox_DsbH	DUF255;	Protein of unknown function, DUF255	Mifsud W	anon	Pfam-B_2331 (release 6.5)	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.18	0.71	-4.52	98	1287	2012-10-03 14:45:55	2003-04-07 12:59:11	10	21	1106	1	594	2317	1224	153.40	47	23.88	CHANGED	sNRLtpppSPYLLQHAcNPV-WaPWGcEAhpcA+ccs+PIhLSIGYusCHWCHVMt+ESFEDt-lApllNcpFVsIKVDREERPDlDplYMsssQhho.GpG......GWPLolFLTP.DtcPFauGTYFP.....c.....s+h...Gh.................PG......FhplLpplschWcp.c.+pplhpsuppl...hptLp	.............................N+LhpppSPYL.hQHA.pNP.........V......cWaPW.u..p.E.....A.h.pcA.+.p.c.s.+.P.I.hL.S.....l.G..Yu.sCH..WCH...VMt+.............E.S.F-Dt...-...l.A.t..l..h.N..c.p.F....V..s.l..K..V..........D......R....E....E.....R.............P....D....l.........D..............p.....l.Y...........M....s.........h.....s...............p.....s..........h....o......G..p....G..................GW.Ph.olFL...TP...-...t.c.......P....Fa..u.G..T..Y..aP.p.........sph........sh.................................su.........F.hpl.L...p.tltphWpp..c..+pclhppupplhptl.p...............................................................................................	0	217	426	530
+1958	PF03192	DUF257		Pyrococcus protein of unknown function, DUF257	Mifsud W	anon	Pfam-B_2788 (release 6.5)	Family	\N	25.00	25.00	25.90	29.10	23.40	22.10	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.13	0.70	-5.03	28	91	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	14	6	77	103	0	204.40	25	94.90	CHANGED	lp-hl.cph+hGEol...LlEYsS..shhchlhatl.lphh+-c...shsllIsDlhDoL.lhh........pplclhGlcsslh..csspVIKlG.GphshGNVlt+l..t.-.shah...ppYtptlpclht...pcs..hIsIlLGlE+lh.hh.pshh-hhhllptltpa.lsscc+..puhYFlNpsllcphsss.hl.hLEEluosV..lclspc...t....hplhKuhp.th.Gh...plpl	........h..chl.pph+hGEsV...LlEYsS.hshsclhhhtl.lphhpcc...shsllIsDlhDohhlhh........ppLchhGlcssh...cslpVIKlG..GphphGsl...lt+l.h.t-.shah...ppYpphlpclhp...pcp...hlslllGl-+lh.hht.psht-h.hhhlps.ltph..lGsccR..huhYFlNpsllpph..p.hlshLEEluosV..lclppc......sp.hhhplhKu.p.p..s..ph..h.......................	0	4	5	43
+1959	PF03193	DUF258		Protein of unknown function, DUF258	Mifsud W	anon	Pfam-B_2832 (release 6.5)	Family	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.98	0.71	-5.05	74	4240	2012-10-05 12:31:08	2003-04-07 12:59:11	11	13	3686	8	935	12978	6178	158.30	36	49.24	CHANGED	hcphhpthcslGYp.lhhhssp..sspulcpLpshLps.+hslhsGpSGVGKSoLlNtLhs...ph........................................phcTuplSpp.s+G+HTTspscLhtl....ssGGhllDTPGhpphslh..hstcplspsFsEhpphh....tpC+F+sCpH...tsEP..uCAVcpAl-pGplst.RYpsYhcllc	......................................................h....ht.Ypp..lGYp...lh..h..susp.........ptpu....l....c....t....L..........p....p....h...L....s.......s......+.......l....o......l...h..s.Gp..SG...VGKSo.L...l....NtLhs.....p..h...........................................................................................................................................p..h..p...T..u....-..l....S.....c......s.........u...+......G......+......H........T......T....s......p....s...c...L..h...p..l.....................p..G....G......h.....l....l...DTP..G..h....p..ph...s...lh..c...l.p...s.......-.p....l.spsFs..E..h...pphh..........tp.C+...F..R...s.CpH...t.p.E..P.......u..CAl....+..p..A.l.-....p.........G....p.....I...s...p...p...RacsYhplh.p........................................................................................................................................................................	0	336	638	814
+1960	PF03196	DUF261		Protein of unknown function, DUF261	Mifsud W	anon	Pfam-B_2687 (release 6.5)	Family	\N	26.10	26.10	26.30	26.40	22.40	26.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.68	0.71	-4.19	8	189	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	32	0	15	139	0	137.30	62	92.16	CHANGED	M.l.KhpppNt.....Ip+aGCYFLClhahh.lhKphc......Fssh-IslsYp+FluLGYI+.sNCaIlNPCtILuhaGIcocVRaESh....sYlssp.sEFEIoElKlcssshhHFlssss..pcVLYDS.LsLK.pGppaplsS+RlF+hp	..........MhIsKIKQsN+sLh.EIQKWGCYFLCLHYYsSlFKphE......FsAaEINsAYhRFlGLGYIK..SNCFIlNPCMILNYYGIRSSVRY...ESh.....sYLuAA.....NEFEISEVK...IccVN.GYHFIATKN..KEILYDS.LDLKs+GKlFKVTSKRIF+l.................	0	11	11	11
+1961	PF03235	DUF262		Protein of unknown function DUF262	Bateman A	anon	Pfam-B_3462 (release 6.5)	Family	\N	29.30	29.30	29.40	29.40	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.80	0.70	-4.38	194	2983	2012-10-01 20:12:50	2003-04-07 12:59:11	9	17	1749	0	669	2580	315	195.70	18	37.50	CHANGED	lppl..hsphp............................h...hlP..p............aQRsYs.W....ppcp.....hppLlcsl.....................................psah........lGsllh............................................ttt..tsphtllDGQQRLTolhh..............hhts........................................................................................................................................................t..hhtphhpttt..............................................pphppphhpshphhpp..................................................................................hh.h.h..................ps...shplFp...plNspGh....tLssh-..lh+shhh	...................................................................h.....htt......................h..hlP.t............aQR.sYs.W.......spcp.................hppLlcsl..............................................h.psa....lGsllh.............................................ppp......psph.llDGQQ....RLTolhh...........hlts....................................................................................................................................................................................................h...t.h....h.p...t.t..................................................................................................................p.t.tpphhp.h.phhtp..........................................................................................................................h.h...h.h...........................ts...s.....plFp....phN.stGh.Ls..-..lhpshh.h.............................................................................................................................................................................................................................................................	0	249	483	593
+1962	PF03237	Terminase_6	DUF264; 	Terminase-like family	Bateman A	anon	Pfam-B_3575 (release 6.5)	Family	This family represents a group of terminase proteins.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.95	0.70	-5.70	41	3063	2012-10-05 12:31:08	2003-04-07 12:59:11	10	17	2033	7	507	3449	4695	362.10	15	76.55	CHANGED	hhhtuppsGKTahhuhphhtpshtss......................psplhlu.sspsphph..............htthhhphspp.hhphphp........tp.hhh...........ssGup.ltahuhptt....stpuhpG.......t..hlahDEhhhhsc.thhpthtpshssptchh.........hhossssst+.hhshhssth.sp.................................................pth.hshp..................hshtDshptu.s.hh....................cplttphsspt..hpphhhupass.............ssuulFphtphphthstt..............s.tttphh........................huhDsu............tssDssuhhlh..............thssspahhlttpptpshshsthsstlpphhp...phssphlsl-sss.....sGpulhphlppth.................hshphs...........csKtshshthpsll...csu+lphsps..........phtshhpslcphhssss.........p..tt+sDhhsAhthAlhpt	.................................................................................................................................................................................................................................tuht.G.tT.h....h.h....s.....h........h....h....h....h....h..tpt.............................pthhhs..s.s..tt.p.ht...........................................hh...h.phh.....t...p............h..p.h.thp......................tp.hhh............................sGs.....p...l....hh.h.us...p....t.t...........shp.s.h...p..G.........................................hl...h.h.DE....h...hh.h............p.............t...............p......t......h....t....p...h....h...h...t....h......t...t..hh................................hho.s.s.s....s..............t....p......h...h............h...h.p..t...t.h.sp.........................................................................................h..hp...........................................h.sh.ts.s..h.....t..h.s.tp..hh......................................pp..l..t..t..p..h.s.spt........hpp...h..h..s..p..hhp............................stu..s..l...a.s..h...t..t..h..p...t..t...h..h.tt..............................................................s..s...t...t.hh.........................................huhD.u..................tss.D.ts.s.hhlh........................................h......ss......p..h.....h..h..l....t..t..h.........t........h.......p.........t......h......s.............t....t....t......p.....hl..t..p..hht..................ph.t.s..t..h.l.h.........h..-sps......................hu.tt.hh..p..lpp..h.............................h.h.h.s.................................ps+...t...h..h......t....htshh..........pt..tp.l..hst.............................h.t.h..t..lt.t..h...h.s.t.........................tp....s...Dhh.uhhhsh...........................................................................................................................................................................................................	0	161	327	421
+1963	PF03266	NTPase_1	DUF265;	NTPase	Mifsud W	anon	Pfam-B_4081 (release 6.5)	Family	This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [1]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [2]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [3].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.03	0.71	-4.54	38	349	2012-10-05 12:31:08	2003-04-07 12:59:11	10	9	303	2	181	414	99	157.30	29	79.34	CHANGED	+lhlTG.PGlGKTTLlpKlhctLppp.shplsGFhTtEVR..csGpRlGFcllslsoGccuhLA+ss.........tsts..+VG+YsVslps...h-plulsslcpt...ppsD...lllIDEIGsMELpopsFhpslcplLs.usps...lluslHcp.......llccl+pp.....sclap....lTpcN.................Rs...tlhpcll	.....................................lhlTG.s.G.lGKTTll.p+.....lh.ptLp..tt...sh..t..........ls....GFh.T..p..E....lR........pt..G..pR..h.GFcll..s...l.....s.Gc..c.s..Luphp..................tt.pl.GpY.s.V.p.lps...........a-pl.ulshLpp.h.........pssc.................llllDEIGtMEl..h..upt......Fhp...sl.....pph....Lp....ssps......llusl.ht..........hlppl+p.p.s...splhp....l...s.pN...Rs.l..pl.........................................................................................................................	0	69	108	142
+1965	PF03270	DUF269		Protein of unknown function, DUF269	Mifsud W	anon	Pfam-B_4172 (release 6.5)	Family	Members of this family may be involved in nitrogen fixation, since they are found within nitrogen fixation operons.	25.00	25.00	28.20	30.50	24.10	20.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.36	0.71	-4.11	41	182	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	157	3	85	173	7	121.40	47	78.61	CHANGED	a-shoDpplLsPaIloKEpRRpIPlhGDPDPsTlhRlchFYpAlAhsIEccTGhhssshhc..lsHEGFGRsllhsGRLVVls+sLR.DlHRFGF-SlpKLA-cGpKhlssulchIccaP-V.Ach	......W-scoDtc.LL.s.PaIloKEpRRp...IPllGDPDPps.lhRlchFYsAVulsIE+pTGlhssPhhc..hsHEGFGRhllhsGRLlVlsKpLR.DVHRFGF-oLpKLA-cGsKhVssulchIcpaP-VAp............	0	21	54	68
+1966	PF03189	Otopetrin	DUF270; 	Otopetrin	Mifsud W	anon	Pfam-B_2323 (release 6.5)	Family	\N	22.80	22.80	22.90	22.90	22.70	22.40	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.45	0.70	-5.48	12	606	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	83	0	443	578	1	212.80	17	64.99	CHANGED	YLRlGAlsFGlGshVY.GlEh...F.h.hsssCpslhluls.hhthlFshhQMpFIFhN..uclshtRa+hlARFGLMHhVAsNLshWhphlltEs...phEIhphtp.t...stpsshhpssptsstthsts.tttc........................................hh.th................................................................................................................................................................................hoppsss.......................................................th.hpstRhphhsshltssusaLasshlEYSLIsAslhahhWKplt.................h....tsshs+ps+phplDCsssppGlFhGIllllholIsllhaalLhpcst.phhAs..lsls-hlhaslshhA...llhuhhp..MRsLca......ppptcu.sLDsILLllu.sG.hlYushullushhshhpsp..sshlsllstlhpllQsslQolFILpuu+p+stusppsRspPG+pIlTFLLlsNluhahhpThEpt+u..uFpshhh-aYGhhsWollh+lohPLsIFYRF	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	124	164	306
+1967	PF03407	Nucleotid_trans	DUF271; 	Nucleotide-diphospho-sugar transferase	Bateman A	anon	Pfam-B_4460 (release 6.6)	Family	Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.26	0.70	-4.56	49	713	2012-10-03 05:28:31	2003-04-07 12:59:11	11	28	132	0	514	739	97	195.10	17	45.37	CHANGED	thlpphlVlAhDppshpts.pphtss.hhhh.h...........shs.tsphhtstsahphhhh+hplhpplLchGhshlhsDsDshWhcsPhshh.................ssDlhhss.Dthssp.spthpphh....................NsGhhal+uospohphhcphhpphtp..ss..........DQslhshhhpp.hh...........................hshphphLstshF.........shFhp...pp.pthps..............hhlHsshph...shp.....sKhpch	...................................................................................................................t...pphllhshDttshphh....t......th.t........h.hhh....................................tt.hhhst..sahp.hh..............h....h+hp.hl.t.plL...p..........h...G...a...s....hlh.sDsDlh..a..h..c...s..P.hs.hh...............................ssDl..hhss..Dth.t.s..t.......t.tphh.............................................................NsGhhah+s.ss...tsh..p.hhcpWh...p....th..tp.........st........................DQss.hsthht.t.........................................................................................hthphthl.sh.....hh................hh.t...........h.t.....................hp.sh.......t.......tKh...........................................................................................................................................................	0	210	362	473
+1968	PF03314	DUF273		Protein of unknown function, DUF273	Mifsud W	anon	Pfam-B_3636 (release 6.5)	Family	\N	30.00	30.00	30.20	30.20	29.20	29.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.72	0.70	-5.04	12	87	2012-10-03 05:28:31	2003-04-07 12:59:11	9	7	10	0	85	68	5	176.00	35	55.45	CHANGED	l+CYsKhHsYchllshDs-....ap..Csp.KDphFRRHCllAKlLssaD..slLFLDADhGVVNPpR+IEEal..ccslDIsFasRFhNWEItuGsYlsRNTpaAlshLpcFAsYE.+LPpSaHGoDNGAlHhaluE+lhPpso.clchC+.Khacp....SpsapDLaTYEuCI+slhGssscFs.KlRIL+K...............GT.GWARDGWLTs.hWpsch.DFMlHGWKsspLh.hPp..lts.ph	.......................................hpCY.t..tY.h.hh..ttt.................ht...C..p....p..........................hF+RHChh....uthL......p........p....hlhhlDuDhullNPpp..................hlE-al..............p.th.DlhhYsR..a..........h..........NaE....lhuGSYls+NT.auhphLpc.aAs.a.E...pLPp.u.hH.GoDNGAlH...............hhlhchhhPp...p......h......p..C..phapt....otshtshhsapsCh+.hhGttp.as..cl+IhpK...............Gp..uWsRD.WLTsshWs.p..DFMhHuhKppp..................................................................	0	32	41	85
+1970	PF03434	DUF276		DUF276 	Finn RD	anon	Pfam-B_4450 (release 6.6)	Family	This family is specific to Borrelia burgdorferi.  The protein is encoded on extra-chromosomal DNA.\	    This domain has no known function.	25.00	25.00	30.20	30.20	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.74	0.70	-5.44	3	157	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	28	0	12	138	0	260.50	73	99.62	CHANGED	MSIVFDSDFGILKRTI+DIVRoKREYLRVNYGINIDDNpSSIYNIIASSLALIEEEIINELNLFFSKMKPGGSYWAAIEEHISS.KSTTYSAVRNALLNL-GIEHsNIKSuAGKANIYLILKEDLLsTsKoNINsPEFKAKlWETLYLTTPSGTLLEGDIEIDGLNSTGQ+KSYKISLGKRKYVYMKVKYKLDLKNYLYLNIDSQIRDIYSRIISNNYhDMGISFEYQDFFAPVNEVKGIKFMEIuICIKDTDTESIoKISDSDFppNQDISIsDDTILLFNTT-RLLIDhD	....MSIVFDSDFGILKRTIKDIVRsKREYLRVNYGINIDDNpSSIYNIIASSLALIEEEIIsELNLFFSKMKPGGTYWAAIEEHISS.KSTTYSAVRsALLNL-GlEasNIKSuAGKANIYLILKEsLLDssKoNINssEFKAKLWETLYLTTPSGTLLEGDIEIDGLNSTGQ+KSYKISLGKRKYVYMKVKYKLDLKNYLYLNIDSQIRDIYSRIISNNYSDMGISFEYQDFFAPVNEVKGIKFMEIusCIKDTDTESIoKIsDSDFppNpDIsIsDDThLLFN.TTDRLLIDh................	0	8	8	8
+1971	PF03353	Lin-8	DUF278; Lin-8_Ec; Lin-8_Ce; 	Ras-mediated vulval-induction antagonist	Finn RD, Pollington J	anon	Pfam-B_3924 (release 6.5)	Family	LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb.Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling [1]. The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity [1].	25.00	25.00	25.30	25.30	23.00	24.00	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.15	0.70	-5.14	14	108	2009-09-11 05:18:49	2003-04-07 12:59:11	10	17	4	0	106	110	0	233.90	14	66.63	CHANGED	lohp-Yhphpppphhphsst...cstlKKVlLshlEcpPphWp..pssphttccWptlG.................................sEVacRTGpl........................lpssplpphappuKssL+p+L+psIhpK+hs+tssEtcLhcWEaYsah+YYRcsLtpaEApLRsc........hptptp.spscD-Ihh-shhp.......p.ppthEpsssss-h.s.Es.ht..sph.........ppsshpcsptsppshs..thsts.p.s............................sps.sushppsSpppps...........htsspp-ss...................sppIs.QspRLhpphPE+s+LlRcsLFcTllAh--t..-apssu-lFpDL.....At.psh++ppR	.........................................................................................................................................p..hth.....hlht.lpphsthht..pt.p.h..p..at.lu.................................hphatRTG.h..........................................hpht.lpphappuKptLpp+lp.hl..p.c.p.hs......tphEppL.hp.W.hY..h+aaRp....h.tphEtthptp.......................................................................................................................................................................................................................................................................................................................................................................................pp........................................................................................................................................................................	0	19	19	106
+1972	PF01709	Transcrip_reg	DUF28;	Transcriptional regulator	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1741 (release 4.1)	Family	This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1 [2]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3].	27.00	27.00	27.80	30.60	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.54	0.70	-5.23	257	5704	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	4795	3	1221	3365	2823	228.30	42	95.40	CHANGED	SKWsNIK++KutpDu+RuKlFoKlu+EIhlAAKt.G.G.sDPssNspLRsAlp+AKssNhPpDsI-RAIcKu.sG...t.....sussa-ElpY.....EGYGPuG.lAllV-slTDN+NRTsu-VRpsFoKs.GGsLGpsGSVuahFc++Ghlhhs.............tshsEDplh....-..ssl-....A.GA-Dl.................p.........s..-....-..............st...h..plhosssshtsVppuLcp.t....Gh...php.su-lshlP.psplpl...ss.-.......sspph.+LlDtLED.DDVQsVYsNh-	.................................pKWsNIcp+Kss......pDup+uKlasK.................hs+EIhlAAK..........t.G..G..sDPcsNspLRhsIc+AKpss.hP+-sI-RAIc+u.sGs........sspsacplpY.....EGaGPu.G....sA.llV-sLTDNpNRTsu.-VRssFsK..............s..G..G..N...lGss.GSVu.a.h.F-+pG.lIshp......................utDt..D.plh....E.tslE....A..Gs.-.DV..............p.........p.-....-............................ss.....h.pl.ho..ss.p-ht...pVpcALc..s...s........Gl...ch..p..suElphl..P..ps.p.spl..........ss.E...stpph.+LlDtLE.DpD.D.VQpVYpNh.....................	0	405	775	1031
+1974	PF03436	DUF281		Domain of unknown function (DUF281) 	Finn RD, Bateman A	anon	Pfam-B_4313 (release 6.6)	Family	This family of worm domain has no known function. The boundaries of the presumed domain are rather uncertain.	25.00	25.00	25.80	25.20	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.38	0.72	-3.91	10	42	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	4	0	39	43	0	58.60	30	28.03	CHANGED	sToDGCophtVpCshNsuh.Cs.............sstLhA-psuGshsssGossushAEuolTCQcDssW.DS	..........tsG.CsphtVpCphssuh..Cs.............sstLhhptsuGt.shsGss.su.p.u.psolTCssDuha...s...	0	20	20	39
+1975	PF03383	Serpentine_r_xa	DUF286; 	Caenorhabditis serpentine receptor-like protein, class xa	Mifsud W, Fenech M	anon	Pfam-B_2888 (release 6.6)	Family	This family contains various Caenorhabditis proteins, some of which are annotated as being serpentine receptors, mainly of the xa class.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.46	7	69	2012-10-03 04:04:29	2003-04-07 12:59:11	10	2	5	0	69	113	0	139.20	32	47.97	CHANGED	phPhlYIhsMslsGllsKls..hhlDhh..s.lh.PstsYtpYRphIGppl.TllsThsYhhPhaLshLMThpRh.IlhpPhcp..hFosp+lhlYshhlhIlshllLLIPahSpCslNFNAps..apsACAPc+HPlThhQNpaLIhlPhsshllNs	..................................hPhsYIhhMhhssh.l.phh....hh..hshh.................h.hh.hs..p......ttY................t..............t...............a.h.......p..h..hGp.h.TlhsohsYhhshhlslLMolpRlh.llhpPhsp..hFosp+lah.YC.h..h.ls...............l.....hsh.h......Ll.IPahSsC.lsFshhphsahosCuP.p+H..............P...lT.hapNpYh.....IhlPhsshhlN...............................................	0	16	20	69
+1976	PF03384	DUF287		Drosophila protein of unknown function, DUF287	Mifsud W	anon	Pfam-B_2926 (release 6.6)	Family	\N	19.30	19.30	21.30	21.30	19.10	17.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.64	0.72	-3.78	13	34	2009-09-11 13:33:43	2003-04-07 12:59:11	9	3	3	0	2	34	0	49.60	42	8.73	CHANGED	IsSIlpPs.-EKhLLccIh-spsscDDlshhDllVDuWccRLltEcKpIaacsla	..............IpSILtPsh-E+.hLpclh-c.pVDDsls.lD.llDSWccRLlsEcKpIaacsla..........	0	0	0	0
+1977	PF03385	DUF288		Protein of unknown function, DUF288	Mifsud W	anon	Pfam-B_3134 (release 6.6)	Family	\N	19.90	19.90	23.10	20.80	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.20	0.70	-6.00	8	118	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	38	0	100	113	35	184.50	29	31.56	CHANGED	RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHsYLKDFKDEKQVYEDSGKMIEFLHNWpCospNSo.lEsCIppLlNDLVKVKLWGc-DApLMEMFLsDLKsMGFEFPpLls.sNah-PYuPSpNEToRDVNCRRMHLEF-Ll-P+Kp..sEsl++ApQKLNYFGDIlsWCNETGYSslospFPSPcQLA+pH-cSYVhQKchNSVLIVVNNYPWKYGMGLIQRLYQPYFATlIFCGSWYPEpFoslDNFTSTlaPINYIHMNPAEIcKGaFAYHCVTLVKELtLsNVpGYFLMuDDsVFNIWQRIDYSRVHHLsG.ShNhpNsWastspaGhpAAK+IlchVKsSTDsKlt-TWpKFDsGLpKauYhN.T-suEspMpSshGKSlSDF	.......................sDlhRuahuQ+lLa...G.hhlsFhP.ss.sh.phRssHs.hhhsFp-Ecpla.psGcll......cFL.pWp....st......l........cplhcLshshscpshWsppDhphhthaLpDLhslGap.Pplht........................................................................................................................................................................................................................................................................................................................................................................................................................................	1	48	63	94
+1978	PF01062	Bestrophin	Worm_family_8;DUF289; 	Bestrophin, RFP-TM, chloride channel	Bateman A, Moxon SJ	anon	[1]	Family	Bestrophin is a 68-kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a depressed light peak in the electrooculogram [1].  VMD2 encodes a 585-amino acid protein with an approximate mass of 68 kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif.  Bestrophin is a plasma membrane protein, localised to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of chloride channels, indicating a direct role for bestrophin in generating the light peak [1]. The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal RFP-TM domain implying important functional properties [2]. The bestrophins are four-pass transmembrane chloride-channel proteins [3], and the RFP-TM or bestrophin domain extends from the N-terminus through approximately 350 amino acids and contains all of the TM domains as well as nearly all reported disease causing mutations [4]. Interestingly, the RFP motif is not conserved evolutionarily back beyond Metazoa, neither is it in plant members.	24.20	23.40	24.60	23.60	22.80	23.30	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.74	0.70	-5.47	123	2221	2009-11-19 14:00:48	2003-04-07 12:59:11	16	18	1111	0	1116	1855	146	255.60	24	74.64	CHANGED	Mh..........Vpsp................shhclLhph+GSlhptlh........hcllhhhhhshllsh....hh..........................hahhhh..hhphshs.s..lls.sLulhLGFpssssYsRWWEuRphhuthlshsRslsppltsh...........lps.....ssp.............ctchl+ctlu...............asthhptt.LRshsstsc.....hpphl.....ppptp.tlp...st...pts.....shhlhhhhuppl.tps.tcpGp.hssh..........hhttltppLsphpsshuss-RlctTPlPhsYohllphslahahlhlshuh.p.........................slshhs.P.lhoslhsahahGhtplucpL.sPFGp-s.sDlsLstl...I-psltp	...................................................................................................................h.h.hh.h.p...u.o.lh......h..lh..........plhh.hhh.....hhlhh.h...................................................h...hh...hh.p.h..shh....s..........l.ls.....hluh....hL.u..F+ss..ss....as.R............ah-uRphhs.hh.tscslhp.h....hsh..............l.s...ptt..............................................htchh.+h.ls...............as.hhhph...h....L.....R.p....s.t........................................................ht.phl...............tpp.t...h.........tt.....tp.........s.....hlhhhh.t.t........l.....ttt....h...p......p..Gp...hs...sh.........................hh.h.pl..p.........plsphpshhush-+lt.sPlPhsYsh..............hlphslahahhhhPhuhh.............................................slt.hh..s...P.hhosl.hsaha....hu..htt...lupp.ltsPF.G.p........c.s..s..D...l.hstl...I-hsl.........................................................................	0	469	658	954
+1979	PF01724	DUF29		Domain of unknown function DUF29	Bashton M, Bateman A	anon	Pfam-B_2003 (release 4.1)	Family	This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Swiss:Q2RPE2, PDB:3fcn, is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerisation module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.	21.60	21.60	22.20	22.10	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.81	0.71	-4.34	89	805	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	164	1	289	1041	50	128.00	32	89.81	CHANGED	LY-pDahhWhpppsphL+p.....tch.spLDhpNLlEElEslG+p-+.cplpSpLtlLlhHLLKapaQ...s..p+pspSWpsoIpppRpcIpchLccsP.SLcsaLspt..hp....csYpcAhc.AtpEotlsh.........ptFPtpCPa..sh-plLspsahP	................hY-pDa.hWhppphphL+p........tph.splDhc.sLlEElEshG+p-+...cplpShLthLlhHLLKhpa...........pp.pspuWptsIpptRpplpch.Lpc.oP......S.L+.s.h..ltph.....hp.....csYpc.Ahp.utpcotls................t.FP...pp...sPa..sh.-.plLstpah.............................	0	57	198	269
+1980	PF03442	CBM_X2	DUF291;	Carbohydrate binding domain X2	Bateman A, Eberhardt R	anon	Bateman A	Domain	This domain binds to cellulose and to bacterial cell walls. It is found in glycosyl hydrolases and in scaffolding proteins of cellulosomes (multiprotein glycosyl hydrolase complexes). In the cellulosome it may aid cellulose degradation by anchoring the cellulosome to the bacterial cell wall and by binding it to its substrate [1]. This domain has an Ig-like fold [2].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.94	0.72	-4.15	41	261	2009-09-13 17:41:48	2003-04-07 12:59:11	9	72	123	1	115	262	11	84.50	29	12.79	CHANGED	oIsPoshsFcKsss..sDhslshshN.GNTLsu..lps.ssssLspGoDYol..SG.sslTlppuYLusl......ss...ussoLsFsFusGs...sssLsl	........................hsssshsFc+....ps..s...........s.....Dlslsl..shN..GN.o.lsu............lp...s..sspsLspGsD....YTl.....uG..ss....lTlppuYLusl........ss.....usssLohpFssGs...s.phpl............................	0	69	95	105
+1981	PF03398	Ist1	DUF292; 	Regulator of Vps4 activity in the MVB pathway	Mifsud W, Coggill P	anon	Pfam-B_3833 (release 6.6)	Family	ESCRT-I, -II, and -III are endosomal sorting complexes required for transporting proteins and carry out cargo sorting and vesicle formation in the multivesicular bodies, MVBs, pathway. These complexes are transiently recruited from the cytoplasm to the endosomal membrane where they bind transmembrane proteins previously marked for degradation by mono-ubiquitination. Assembly of ESCRT-III, a complex composed of at least four subunits (Vps2, Vps24, Vps20, Snf7), is intimately linked with MVB vesicle formation, its disassembly being an essential step in the MVB vesicle formation, a reaction that is carried out by Vps4, an AAA-type ATPase. The family Ist1 is a regulator of Vps4 activity; by interacting with Did2 and Vps4, Ist1 appears to regulate the recruitment and oligomerisation of Vps4. Together Ist1, Did2, and Vta1 form a network of interconnected regulatory proteins that modulate Vps4 activity, thereby regulating the flow of cargo through the MVB pathway [1].	32.50	32.50	33.40	33.00	32.30	32.00	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.90	0.71	-4.84	44	593	2009-09-13 16:20:19	2003-04-07 12:59:11	9	15	281	8	399	584	6	152.10	33	39.47	CHANGED	Kot.L+hulsRL+hlppK+pshs+ptR+-lApLLptG+p.................pp.A+lRVEplI+--hhlEshEllElYCELLlsRlsllpp.................ppsssslcEAlsollaAusRh.sEl.ELppl+shhspKa.G+-Fsttshs.t...sssVsp+llcKLs.spsPspchh.thLpEIAcpaslsa	.......................................+s.L+hslsRl+hl.ppK+...........p.....thspptR+-lAph.LpsG..+p............................................................ppA+lR....V.........EplI+--.hlpshEllElaC-LllsRhsllpp.................................................cphssslpE...Aluo..llaAusRh.s-ls...ELptl+...shhstKY.G+-Fstt.....shp.t.....tstVspc.lhcKLu.s........psPstthh.phLtEIAcpasl.a....................................	0	110	222	321
+1982	PF03444	HrcA_DNA-bdg	DUF293;	Winged helix-turn-helix transcription repressor, HrcA DNA-binding	Bateman A	anon	Bateman A	Family	This domain is always found with a pair of CBS domains Pfam:PF00571.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.48	0.72	-4.54	13	1056	2012-10-04 14:01:12	2003-04-07 12:59:11	10	4	1032	0	280	1296	281	76.20	43	22.68	CHANGED	pLTslQ+-ILpsLIsLYccp.spslKGcEIA-hlsRNPGTlRNQMQuLKuLGLV-GVPGP+GGYhPTscAY-sLslps.s	.................................lTpRQppILphII-h.Y..t.po...tcPV.G.S+sL..t..c..p..l..s......S..s....A....TIRN-MucLEchG.L.l.cp......ps.SuG.....RhPo.tuh........hsssh............................	0	77	176	236
+1983	PF03445	DUF294		Putative nucleotidyltransferase DUF294	Bateman A	anon	Bateman A	Family	This domain is found associated with Pfam:PF00571.  This region is uncharacterised, however it seems to be similar to Pfam:PF01909, conserving the DXD motif.\	\	      This strongly suggests that members of this family are also nucleotidyltransferases (Bateman A pers. obs.).	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.58	0.71	-4.56	86	1219	2012-10-02 22:47:23	2003-04-07 12:59:11	8	171	696	0	561	1623	276	130.00	27	18.27	CHANGED	pplsplhtslhtpG....spsptlspllsplsDtlhcRllpLshtpht......s..sssasalshGSpGRtEQhltTDQDNuLlhsD...........tsttptaatphupclspsLspsGashCsGslMAsNPpWptslspWcpphppWlppPs...sc	...................................p....thh.thhtps.h.p.sch..lsp.h...lutl...sc...t...hh...p+ll.c..L..s....tphus...............s..PssashlshGSpGRpEQhlhoDQDNAlllp-.......................tsptpttaFtpluchl...spsLtph.....GashCsGphMssNspWphshptWpphhtpWlttsp.........................................	0	301	440	518
+1984	PF03479	DUF296		Domain of unknown function (DUF296)	Bateman A, Dlakic M	anon	Pfam-B_796 (release 7.0) & Dlakic M	Domain	This putative domain is found in proteins that contain AT-hook motifs Pfam:PF02178, which strongly suggests a DNA-binding function for the proteins as a whole. There are three highly conserved histidine residues, eg at 117, 119 and 133 in Swiss:Q46QL5, which should be a structurally conserved metal-binding unit, based on structural comparison with known metal-binding structures. The proteins should work as trimers.	25.00	25.00	25.80	25.00	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.39	0.71	-4.49	113	1687	2009-11-26 14:38:53	2003-04-07 12:59:11	10	15	1088	11	617	1176	262	116.50	29	57.50	CHANGED	hcsallclssGp.................Dlhpslpp...aupccshtsuhl.ouhG.ulsssslph..........s.......tp..h..sshsh.cuphEIlSLsGolh..........s.t.tsshsHLHlslus.spGplhGGplh.Gsl.hssu-lhlhthshtthpp	..................................h.p.aslcltsGp.................Dlhpplts....Fup...p...p.p.l.p.s.shl.uusG.ulssl..sL+h...............s............................sp...tsshpl....pG.p.aEllSLsGolt.....................s.st.....hH.LHlsl.....u...s...s.p.........G...p......s..lGGHl...h.......G..sl..tsssElhlhshs.h....h...........................	0	140	390	516
+1985	PF03537	Glyco_hydro_114	DUF297; Glyco_hydro_114; GHL7;	Glycoside-hydrolase family GH114	Griffiths-Jones SR	anon	PRINTS	Family	This family is recognised as a glycosyl-hydrolase family, number 114.  It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases [1].	27.00	27.00	27.10	27.00	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.46	0.72	-4.19	128	403	2012-10-03 05:44:19	2003-04-07 12:59:11	8	12	334	6	208	401	21	78.40	24	25.17	CHANGED	ssshhpP..sss......ssWpaQLs.........us..........h.sss...........sss......slhslDhh.c.............ss.....tttltt.L..+sp...G....+tlICYhSuGshEs......aR....s.D.t.....s....p....hsts	.................................t.........t.s......tsath.Ls..........st..........h.pss.................ssh...clhslDhh.p........................hs.....tppltt...L..+sp..G..+hVlsYlssGshEs....aRs..h....pp.a...s................	0	87	139	182
+1986	PF03618	Kinase-PPPase	DUF299;	Kinase/pyrophosphorylase	Finn RD, Eberhardt R	anon	Pfam-B_3403 (release 7.0)	Family	This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity [1-3].	22.10	22.10	22.40	23.20	21.00	19.90	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.63	0.70	-4.89	121	2713	2009-09-10 22:59:03	2003-04-07 12:59:11	9	2	2465	0	532	1496	1541	253.70	38	92.63	CHANGED	lallSDuTGtTA-slu+AsluQF.......shp..h.phpphPalcspcplpcllpplpp...psu......llhaTlVssclpphlpppspthth.tlDlhsshlsslpphLGh.........ps.p....tpsGthHplscs....YacRI-AlpFulpaDDG.psscslpcADllLlGVSRouKTPsSlYLAh.pGlKsANlPLls...-.......splPcpLhph...ppKlhGLTIsP-RLtpIRppRhhsht...................upYushcplppElphAcplac+..uhshI-sTp+SIEEsAstIl	.....................lahlSDuoG.TAEhlu+AshuQF................................s..sp.....h..phhph..Palcsppchcp.llpp.lpp........ppu........lVhaTlVps-l+phlt.p.u.p.t.h....shDlhpslls.lppphth........................cP.p.....ps.u.tsH..t..L..sss....YapRIsAI-FultaDDGt.s.s.+.s.ltcADllLlGVSRouKTPhSlYLAh.hGl+sANhPlls...-.......lslPspLh..th.......pcK.lhGLTIsP-+LspIRc.ERhps..................................opYAshcphppEls.s-plhc+..shshIssTspSlEEhAspIl................	0	164	320	430
+1989	PF03625	DUF302		Domain of unknown function DUF302 	Yeats C	anon	Yeats C	Domain	Domain is found in an undescribed set of proteins. Normally occurs uniquely within a sequence, but is found as a tandem repeat (Swiss:Q9X8B8). Shows interesting phylogenetic distribution with majority of examples in bacteria and archaea, but also in in D.melanogaster (e.g. Swiss:Q9VA18).	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.08	0.72	-4.40	170	1152	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	862	4	381	987	109	63.90	27	39.52	CHANGED	clDhptshcptshp...........hpshpllhhsNPphupphhpts..plGhhLPp.+llVhc......psGpshlshhcP	..............................lDhttshpptshp.....................htshpllhhsNPp.......hus.hhp..tc..sp..lul.LPh.+lllhct...........ssGpshlshhp....................	0	118	258	338
+1990	PF03629	DUF303		Domain of unknown function (DUF303) 	Finn RD	anon	Pfam-B_3622 (release 7.0)	Family	Distribution of this domain seems limited to prokaryotes and viruses. 	21.20	5.70	21.30	5.80	21.10	5.40	hmmbuild  -o /dev/null --hand HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-12.04	0.70	-5.16	136	2378	2012-10-02 11:02:24	2003-04-07 12:59:11	13	60	784	11	391	2310	644	279.90	27	56.17	CHANGED	G-VWLsoGQSNMp.....h.ht............shts.sp..............pphtps..sp.PplRhh...ph........t..s.p............s.tp.............spWp.sostss....t.t.....h......................oAsuaaFu+pLtpp.l..slPlGLIs.suhGGoslE.....sWhstp..sh.tt..th....t.htt............t.....................................................................................................................................................................................................ssLYNuMlpPlt.sh................sl+GslWYQGEuNs.....t.t..................pYtphhsslIpsWRppa........s.......ps..-hP..FhhlQLu...........sahtt.............................st.ths.lR-sQ.tpshtpl.....sNsuhs...............sshD.....h...up.psI...............HPpsKpplGcRLAhhAhph	...............................................................................................................................................................................................................................................................................................................VhlhuGQSNh...........................uhup.uh..................s-hhcu......sp..PpI+.l..................pp.shp.....................s...............tt..........spapshhPtst....s.c..................h...........................su..uh.a.hA+...cLhshl.............sss.lhLls.sshGGSuhp.....shspss.........th..ts..s..s......t.................t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................psLY..ps...hlsts+..uh.................slhull.WhQGE.Dh....sss........................pas...t...h...Fss...hlppaRt.-.h........................................s..........ts.......slP.ahhs.phs............ahppp....................................h...........................................................................................................................................................p....................................................................................	0	191	307	348
+1991	PF03733	DUF307		Domain of unknown function (DUF307)	Yeats C	anon	Yeats C	Domain	Domain occurs as one or more copies in a small family of putative membrane proteins.	21.20	21.20	22.60	21.60	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.56	0.72	-3.53	122	2967	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1534	0	655	1690	93	52.80	40	43.34	CHANGED	hlhNllWhl.huG.halulualluullhslTIlG.......IPaGhtsa+lushsLhPFG+p	....hlhNIlWhl.hu.G.aahsLual.lu.ul.....ltsloIIG........IPh....Ghusa+lu.tluLhPaGpp.........	0	171	375	544
+1992	PF03729	DUF308	RUF1; 	Short repeat of unknown function (DUF308)	Yeats C	anon	Yeats C	Repeat	Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X  (#=hydrophobic).	25.00	15.00	25.00	15.00	24.90	14.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.70	0.72	-3.98	354	6171	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	1945	0	1223	3772	186	64.10	19	81.07	CHANGED	lhGllhlllGllslhhPhhsshsl....s.hllGhhhllsGlhpl.h.tshp.....pph.t....shhhhllhGllhllhG.lhllh	............................ullhllhGll.hl.h.t..Phh..uhh...sl........s.hl....lu...h...h...hllsGlhpl..h..tshp.......pph.................hh.hh.uhh.hhhuhhh..h..................................	0	391	835	1043
+1993	PF03745	DUF309		Domain of unknown function (DUF309)	Bateman A	anon	COG1547	Family	This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	21.20	21.20	21.50	23.40	19.00	21.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.08	0.72	-4.52	100	762	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	716	5	231	570	211	62.40	35	37.77	CHANGED	sthptulphasptcaacuHEsLEthWh....pssss..c+phhQGllQlAVuhhH.hpcGNhpG...AhtLh	.........h..lphhhphas.ctcYFpCH-lLE-.hW+....ppssh.....ccshlhGLIphAsuhaH.hcRsNhpGAh+h................	1	68	158	208
+1994	PF01732	DUF31		Putative peptidase (DUF31)	Bashton M, Bateman A	anon	Pfam-B_2152 (release 4.1)	Domain	This domain has no known function. It is found in various hypothetical proteins and putative lipoproteins from mycoplasmas. It appears to be related to the superfamily of trypsin peptidases and so may have a peptidase function.	21.30	21.30	21.50	21.40	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.49	0.70	-5.13	40	325	2012-10-02 13:45:52	2003-04-07 12:59:11	11	4	69	0	65	293	0	366.40	20	54.21	CHANGED	s-hY+phhcpTFulpasstpp...............................................................p...............................................pttGTuWllDYptsp.........................sspss......hphYlATNlHVhstLhst.s.......................................................................................................................shpspspshsLs+hspssshpsphspsp..........ppsptphshhsts.........................................ssKplasAsDFlpp..ssp.h.t..........................................pphpphp.shstasDFAVlElchph.p.........................sspphhchlsss...................atthpsptpp......hphhs......pphhpp..htph..........................................hahlGY.....Psspss..............................................shahststth.tp.t.........sththsphptss..hs.p.thpsh.spsulscshlst............................t.....ppYtpaGhshhhpph.shtuGuSGShlhspssp....llGI....aau	..............................................................................-hYcphh.poaulphhs.ts..........................................................................................................................tt................................................tt..ts.GTsWIlDap..h...sp..........................s.s.c.s......h+aYhATNhHVhs.h......................................................................................................................................shpspstshsls+hpsss.p.hppphphss................ppph.phhhhp.p.....................................................p.......sh+tla..suh.D..F.lpp..pstphht....................................................ppppphp...shstasDFAVlElcaph...........................................ssppltchlsss.......Yt..sppppp......hpahs...........pphhpp...htph................................................hahhGY.....Psspps.............................t....................tpp...........Slahsts..ph.pp.h.............sth..tphptss...hp.t.thpsh..spsulhcshlst...........................................................h...hthGhphh..pph..s.tuGuSGS....lh..........sppsp....llGIaa...................................................................	0	47	61	63
+1995	PF03750	DUF310		Protein of unknown function (DUF310)	Bateman A	anon	COG1421	Family	This family contains a number of archaeal proteins that are completely uncharacterised. The proteins are between 130 and 160 amino acids long. Their C-terminus contains several conserved residues.	24.60	24.60	27.40	28.50	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.56	0.71	-3.91	10	220	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	215	0	73	182	9	122.60	25	86.48	CHANGED	hlsshsc.ssptLlcpAE+lG..chLuc.ssLsToQIRclaspV+s.....I-pcscshpp.......lppcLhhLKPKLAYpsGRhp........tulcsLhElLccslcpl.....scchc+..FcpFhcFFEAIVAYHRaYGG+p	....................................hptt................t..h......h.....t..................p..........l.oToQlRplhsh...l.sp.............lt...schppptp.t................pltpc...l...phL+s+hsYpsGRcp................sl+sF.h...c..h..l..p..csl..-.....tl................tcs.tcp......h.tcFscahEAllAY+Kahs............	0	32	46	62
+1997	PF03759	PRONE	DUF315; 	PRONE (Plant-specific Rop nucleotide exchanger)	Finn RD, Wood V, Mistry J	anon	Pfam-B_3610 (release 7.0)	Family	This is a functional guanine exchange factor (GEF) of plant Rho GTPase [3].	19.00	19.00	21.10	20.00	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.27	0.70	-5.91	16	263	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	22	6	163	260	0	316.50	52	68.73	CHANGED	tt.u-hEhMKERFuKLLLGEDMSGuGKGVsoALAlSNAITNLuAolFGpph+LEPhssE+KshW+REh-WLLSVsDaIVEFsPotQph.sG.sphEVMsoRsRoDLahNLPAL+KLDsMLl-hLDuFc-.TEFWYl-ps.............ttuu.cp..spRp-EKWWLPsP+VPPsGLSEpuR+pLppp+-ssNQlLKAAMAINuplLuEM-IP-SYlEoLPKsG+uuLGDsIYRhl.Ts-pFoP-plLssLDLSSEHcsL-lsNRlEAShalWRRKhpt+..........ssKS..oWustVp.h......h-KpclhtERAEoLLhpLKQRaPGLsQooLDhoKIQYNKDVGpAILESYSRVLESLAaslhuRI-DVLasDchs+pps	..........................s-hEhMKE+FuKLLLGEDMSGuGKGVsoALAlSNAITNLs................AolFGp..h+LEPhss-+KshW+REh-WLLSVs....DaIVEhsP.ohQph.sG.sphElMss+.RsDlhhNlPAL+KLDsMLl-hLDuFpc..sEFWYlcps........................tsss.ct....s.pRp--KWWLPsPpV.PssGLS-tsR+.Lppp+-sssQlLKAAMAINuplLsEM-lP-sYh-oLPK.........s....G...........+usLGD.lY+hl...Ts-pFsP-plLss.....l-...........LSoEHpsL...-lt...NRlEAuhhlW+++hp.pp....................ps+o.....oW.shVp............h-..Kp.ph.htcR...AEslLhhLKpRFPGLsQosLDhsKIQaN......+.............DVGpuILESYSRVLESLAaslhuRI-DlLhsDphspp.s..............................	0	21	94	128
+1998	PF03773	DUF318		Predicted permease	Bateman A	anon	COG0701	Family	This family of integral membrane proteins are predicted to be permeases of unknown specificity.	24.50	24.50	24.60	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.98	0.70	-5.44	12	3218	2009-09-14 00:13:01	2003-04-07 12:59:11	8	17	2210	0	803	2344	347	274.70	22	88.25	CHANGED	shlshh.slhh.hhlcsl.hLlhuhhluuhIpshlscphlhchLsc..s+hhuhhluulhGhlhshCsCuhlPlhtthhcpGsshssAhsFLhuuPhlN.lslhhshhshG..hplshhRllsuhlhulllGllhphhhptp........................hlhshp...............................h.hls.sph.hsshh.+ht.shh.....cshs.hhphh..hLllGshIAuslpsal.Ppshlhs.hGt.....sslhushlhhlluhlh.hsohs-sslstuLhpt.huhGsslAhLhhGshlsl.shhhlhphhtt+hlhhhlshlsl.shlsuhlhsh	.....................................................................................t...t...thh.h....hhlc.h.h..hll.l.uh....hlu..uhlpshls.......c...h..lh+h.L.sp.....sp...h..h...u..h.hh.us...h....hGhhhPhCpCuslPlhtuhhp.ptsshs.s.sh.s.FhhsuP..hl..N.P.h.slhhh.hh.shG......hp..hshh+....h..lsullhullhG..h...l.lthhhtpt............................................................................................................................h.............................................................................................................................t....h.....t..t...p...h.....t....t..h...t..h.hhh..........psh.p..hh.p.h.h...alll....Gsh...l.uu..........h..........h.......psa..l....Ppphhts...hut.........................ss.h.h....ul.hlh....h..lluhhh..l.sutush.ls....t....u.h..h...tt...hu.h.ushlAhlhhssh.lsl.plh.hh.pphht.h....+..hlhhhh.s.hl..hh.s.shl.huhlh..h........................................................................................................................................	0	295	561	699
+2001	PF03778	DUF321		Protein of unknown function (DUF321) 	Finn RD	anon	Pfam-B_876 (release 7.0)	Repeat	This family may be related to the FARP (FMRFamide) family, Pfam:PF01581.  Currently this repeat was only detectable in Arabidopsis thaliana. 	20.60	20.60	24.40	21.10	18.00	20.00	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.13	0.72	-6.26	0.72	-4.48	32	105	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	1	0	2	105	0	19.10	66	55.12	CHANGED	LRFWRENHGFoFLAtK.pla	LRFWRENaGFTFLAGK.pVY.	1	2	2	2
+2002	PF03780	Asp23	DUF322;	Asp23 family	Bateman A	anon	COG1302	Family	The alkaline shock protein Asp23 was identified as an alkaline shock protein [1] that was expressed in a sigmaB-dependent manner in Staphylococcus aureus.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-3.78	173	4865	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1784	0	734	2174	33	105.20	28	72.18	CHANGED	phGplpIuscVltpIsGlAup-l.GVhuhsus...hhsslschl.sp...cshs+GVpV.chsp.ctplslDlhlllcYGssIsclupplpcpVcpslcpMTGLcVspVNlpVpslp	..........................................................p..GplplsscVltp..I..sGhAsp.cl.Glhuhsut........hhsslt.c..hl..sp..........psh..s...+GV...p.V....ch..........s....cpplsl.DlhlllpYG.s.plsclupplpcpVppslcphT.ulp...l.s.pVNlpVpsl..................	0	308	520	657
+2003	PF03781	FGE-sulfatase	DUF323; 	Sulfatase-modifying factor enzyme 1	Bateman A, Wood V, Mistry J	anon	COG1262	Domain	This domain is found in eukaryotic proteins [1] required for post-translational sulfatase modification (SUMF1).  These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD) [2]. The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase.  Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases [3]. FGE is localised to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesised sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilised by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidised cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases [4]. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase [5,6].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.91	0.70	-5.03	22	4674	2009-01-15 18:05:59	2003-04-07 12:59:11	11	147	2003	22	1863	4765	2666	226.90	22	55.13	CHANGED	pssshVhlsGGsFth...Gs.....................tspEsPh+phpl.psFhIsch.VTstpatpFlpt...ssh................................................h....ht.hppspt......ttsspPVspVoa.DAhAYApWhuc.......................................RLPTEsEWEhAARuG....tuphasaGsphts.....................t.stttsstsstpt.ssPVssass..NshGLhDMhGNVWEWTsshap...........................t.s....sssh+Vl+GGuahst.....sthhRsuhR.s.t..tssstssplGFRssp	.........................................................................................................h.....h.l...s...G...h.h....G..........................................t....-....ts......c..p..lpl..ps...F..hhsph.V..T..stpa...t...tahpt........st............................................................................................................................................................................................................h.......p..........................................................................t............t...........pt..P......V......h..pVoa.-.At.s.....a.spWh.u..p.............................................................................................................R.....LPTEsE......W....E....h....A...A......+.u..s.....................t..t........h.....h..s.s.p.............................................................................................t..................t..t...........h.....s.....t....s...V...s....t.h.s.................s.sh..G.....l.a.-.hhGNVaEWst.s..at............................................................t................................t....s..t........t..l....h.+..G...Gu..ahs..........sth...hRss...hR....t................t.......t...........t....h.GFRhs........................................................................	0	719	1285	1627
+2004	PF03787	RAMPs	DUF324; 	RAMP superfamily	Bateman A	anon	COG1332, COG1567, COG1367	Family	The molecular function of these proteins is not yet known.  However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.47	0.70	-4.49	154	1749	2012-10-01 21:23:39	2003-04-07 12:59:11	10	11	493	0	736	1663	29	234.30	14	68.48	CHANGED	plpsloP.la......hGsu........................................................................................................................tssstshl.uool+GslR.....hhhc..................thht.........................t.tt.tttt..t.t..............................................................................................................................................................................................h.splF.....Gss........................................shtupltlpss.................................................................................................................................h..hh.hththptphthspt.t..................ap..hchh.tt.......................................................................tt..ppttphhtphLphh..........................thhslG....uppp.......hG.hGt..hp	............................................................................................................................................................................hhos..lhlGsu...................................................................................................................................................................................h....hp.t.h.t..s.......h.P...hIPG...SSlKG.tlR................shhp.............................................................................................................phht....................................................................................t......................................................................................................................................................................................................................................................................................................................................................................hhpplF.............Gsp..........................................s...htu...plhhp....D.s..h.h....................................................................................................................................................................................................................................................................................................................h..t...h..h.t..hp.h..p..h..t.lsp...pttst..........................................hp.....hchl.tt........................................................................................................................................................t....t............p....t.........h...t....h.hht.hhphh......................................t....htlG..utts.hGhGhh............................................................................................................................................................................................................................................................................................................................................................................................................................................	1	388	536	643
+2005	PF03804	DUF325		Viral domain of unknown function	Griffiths-Jones SR	anon	PRODOM	Family	\N	21.50	21.50	21.90	127.20	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.31	0.72	-4.26	6	14	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	14	0	0	14	0	72.40	66	48.77	CHANGED	l+FSLRLTpEaKENIVAHlcHLsRLRALIDGKVTpADVRRFGFsDRNALVuACMsVNVQsYs.PDuTI..RhQP	lKauLRLTpEYKENIlsHhDHLoRLRsLIDGhlpspDVpRFshhsRNsLlSACMplNVpsYh.PsuTIDMRhQP	0	0	0	0
+2006	PF03885	DUF327		Protein of unknown function (DUF327)	Bateman A	anon	COG1728	Family	The proteins in this family are around 140-170 residues in length. The proteins contain many conserved residues. with the most conserved motifs found in the central and C-terminal region. The function of these proteins is unknown.	25.80	25.80	26.50	34.10	24.90	25.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.80	0.71	-4.37	51	443	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	442	2	118	290	4	147.00	26	98.51	CHANGED	M+Ip............t.ppht.tshtpsptcpst.ss..psFtphh.sptcpcttp...........ccLppllscIcctGp+LscshshpsltpYKchlKcFLcpslppshplcpppuh....s.t..ps+haplVcplDc+LpcLsp..pllspc+cslsllspIsEIpGLllDlah	.......................................................t......t..tt..t.ct..sp.sp.....tsFspph..sptcccph.................-plpphlcpIsctGc+LtppholcslhpYKphVKpFLp.hlcsshphccppuh................p.th..psphhslV+pl-pcLp-Lsc..pllsscpsplclLspIsEIpGLllslh...	0	54	92	102
+2007	PF03883	DUF328		Protein of unknown function (DUF328)	Bateman A	anon	COG3022	Family	Members of this family are functionally uncharacterised. They are about 250 amino acids in length.	24.60	24.60	24.70	24.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.57	0.70	-5.08	127	2603	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2522	0	474	1849	1083	236.40	36	94.32	CHANGED	M.LlllSPAKsL.chp..ss..ss...tpho....pPphhcpuppLlchh.+plos...pclupLM.plS-cLAtLNhtRapsa....p...t..ps....u+...AlhAFs.GDVYpGL-ApoLspp.shsaAQp+LRILSGLYGlLRPLDhhpPYRLEMGT+Ls..s.pGpsLYpFWGsploptLspthtt........splllNLASsEYaKulc..ptl.pspllossFp-.K..sGp..hKlISaaAK+ARGhMsRallcpplsss-p..L+sF....shsGYtastphS	...................................MhIllSPAKshshp............ss....sh............tph.o..........Pph.h...sp...opp.L..l.cth....cpl.os.............splppL.h.plS......-.clAshNhtRapsap.................t.ps.....up.....AlhuFp.GslYp..uLps.cs......h..ocs...-h......casQpHLRlLSGLYGlLRP.L.Dh.hpPYRLE..MGs+..Lt..........sp....G....+............s...LYpFWssh..l...o.ptL.sctht..................cplllNLASsEYh+slcs......tpl.......ps..........c........llss.h.F...h.-pK.......sGc.....hKllS........aaAK+ARGhMsRall..c..N..p..l..p..p..s-p.Lp.sF.......shtGYhastp.S...........................	0	130	290	396
+2008	PF03884	DUF329		Domain of unknown function (DUF329)	Bateman A	anon	COG3024	Domain	The function of this short domain is unknown it contains four conserved cysteines and may therefore be involved in zinc binding.	19.80	19.80	19.80	19.90	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.34	0.72	-4.41	121	1426	2012-10-03 05:12:49	2003-04-07 12:59:11	9	3	1418	1	310	792	215	59.70	48	90.21	CHANGED	h..s........VpCPpCt+tl.Wt.ps.ta.RPFCScRCphIDLGcWAsEcapIPup........ss-t.sp-p	......sl....VsCPsCGKsV......sW......s..p.s..sa..RPFCScRCp.LIDLGcWAuEEppIPuss-.....-sDt...........................	0	71	164	240
+2009	PF03886	DUF330		Protein of unknown function (DUF330)	Bateman A, Sammut SJ	anon	COG3009	Family	The proteins in this family are uncharacterised. The proteins are 170-190 amino residues in length.	21.00	21.00	21.10	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-4.85	95	1859	2012-10-01 20:48:06	2003-04-07 12:59:11	8	5	1526	8	438	1301	80	157.30	22	77.37	CHANGED	YpL.......ssssssssssssss.....lhlssVslsshLspsplVhpp..ssspl.phscpspWAssLsptlppsLspsLspphssttlss.s.........ssssshplpls..lpcFcut....ssspshlsup..Wplhs...tp.......sp..........shss+s.hphptshsus.u....hsulVsAhspul.spLuppIA	............................................Y.L........stssstsssstst........hhLhlt.pVsls.c.hLs.ss..s..lV.hps......sss.p.h..shh.p..sshWAssLsptlpsp..LsssLspp....hsshslssts............hsssphpLpls....l..pp....F....pup................su..p....s......h...l...s..up....ahLhp.......p....................ut................lhpRs.Fp..l.pts.hs.ps..s........hss..hV.pu.hspuh.sphuspIs.................................................................	0	105	240	342
+2010	PF03889	DUF331		Domain of unknown function	Bateman A	anon	COG3036	Domain	Members of this family are uncharacterised proteins from a number of bacterial species.  The proteins range in size from 50-70 residues.	25.00	25.00	25.90	25.20	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.80	0.72	-4.67	20	635	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	633	0	89	304	9	39.20	62	53.07	CHANGED	GsI+.DNALcALVTSpLF+pRVEKsKKGKGSYpRKs......K+pG	...........GpIKDNAlcALl+DPLFRpRVEKsKKGKGSYpRKu......KH................	0	9	28	58
+2012	PF03891	DUF333		Domain of unknown function (DUF333)	Bateman A	anon	COG3042	Domain	This small domain of about 70 residues is found in a number of bacterial proteins.  It is found at the N-terminus the of Swiss:O28332 protein. The proteins containing this domain are uncharacterised.	25.00	25.00	26.20	25.40	23.10	24.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.61	0.72	-4.16	57	1338	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	848	0	141	468	11	48.40	44	56.10	CHANGED	luhA.NPA.......usaChptGGplpltppspG...phGhCpLPsGcthEEWsLaRppp	....................thsNPA.......us.CtphGGoLtsspph.p.G...shuhCtLP.sGcph-EWuLhRtsp.........	0	22	53	100
+2013	PF03904	DUF334		Domain of unknown function (DUF334)	Finn RD	anon	DOMO:DM04800;	Family	Staphylococcus aureus plasmid proteins with no characterised function.	21.40	21.40	21.70	22.20	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.64	0.70	-5.03	2	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	34	0	1	40	1	157.90	31	83.28	CHANGED	.hthQ.h.S.cs.KpNcps.NhQhpSK.TGT.SpphQpoLpNEELpELK+QNKLllKYluEhpEpQclREKE.ptIpSpLKcsTcDFps+uhKl+NDFVclLQcpLp+VssE-lc..lt+slYtVREE.cpMLpEVKpSHEHYQpRQK.LFTGIGAMLLVFMLFALIMTIGpDFMuFLHVDsLQNAIAuKlKASEGFhohlWYIAYGLPYlLAIGLFIhLYEWIRA+FHD	.........................................................................................................................p...pp.pth....phppTtccFh.p..s.phppDFlchlpcpLpcl..ss-..php.t..hpp-.lhc.p...pE.cphLp-.V+p...uhEchpppppplasuhsuhLhVFhlFsllMhhG.Dhh.............................................................hh....................................	0	0	1	1
+2015	PF03928	DUF336		Domain of unknown function (DUF336)	Bateman A, Moxon SJ	anon	COG3193	Family	This family contains uncharacterised sequences, including several GlcG proteins. The alignment contains many conserved motifs that are suggestive of cofactor binding and  enzymatic activity.	20.70	20.70	21.20	21.30	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.48	0.71	-4.35	36	2508	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	1635	13	741	1913	457	128.80	27	74.31	CHANGED	sslshpsAh....phspAAhttApphuht.lslAV.VDt.sGphls.hhRhsGAshtosclAtcKAaTAsshtt.....sTtphsptlps.ssshhtshsth.....sphshhGGGlPlh.hcG.tl.lGulGVSGs.osppDcthAptulpAl	.............................................................................................lohptAp..plht....suhpp.....Ap.c.........s...h...lslul..lDs..sG..p.hls..h.h..R..h....-s.u..s.....h.s..sclutcKA.hTAst.hcp...................................sottht..p..h....s..ps....sts.hhshtsth....................sthsshuG.GlPlh...hcG....p.........l....lG.ulGVSGs..sscpDtplApsult..h......................................	0	202	445	612
+2016	PF03929	PepSY_TM	DUF337;	PepSY-associated TM helix	Bateman A, Yeats C	anon	Yeats C	Family	This alignment represents a conserved TM helix found in family of bacterial proteins. The previous DUF337 alignment covered the whole (or most) of the protein. Analysis with dotter (E Sonnhammer) indicated that the same region was represented multiple times within the old alignment.	21.50	19.00	21.50	19.00	21.40	18.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.17	0.74	-7.28	0.74	-3.18	216	157	2012-10-01 23:59:14	2003-04-07 12:59:11	11	13	141	0	57	868	51	35.30	47	13.52	CHANGED	hhplHp.................hhshhsshhhllhsloGlhhh	.................sDLHKGRss........GssWtWhlDlhAlhhllFslTGlhLL.......	0	14	29	44
+2017	PF03937	Sdh5	DUF339; TPR_div1;	Flavinator of succinate dehydrogenase	Bateman A, Yeats C, McNeil M, Eberhardt R	anon	COG2938	Domain	This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle.\	Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans [1]. Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria [2].  This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true.	20.90	20.90	22.30	21.70	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.31	0.72	-4.29	149	1961	2012-09-24 13:32:29	2003-04-07 12:59:11	11	9	1889	6	589	1180	1046	73.20	35	68.49	CHANGED	cppRLhacu.RRGhhEhDllLssFhcpph..ssls-pchptac.pLLsts..D.DLapWlhsp........shPp....chph......tllpplp	.........p+tRlpaps.RRGMhElDlllhsFh-c..p..h..ssLo-s-hphF..cLL.-..ps.........D..sDLasWlhs+........spPs....chcht...thlchI............................	0	158	312	458
+2018	PF01784	NIF3	DUF34;	NIF3 (NGG1p interacting factor 3)	Bashton M, Bateman A	anon	Pfam-B_1006 (release 4.2)	Family	This family contains several NIF3 (NGG1p interacting factor 3) protein homologues. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown [1,2].	23.40	23.40	23.70	23.70	22.10	23.30	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.86	0.70	-4.80	122	4441	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	4063	30	1020	3147	628	264.00	27	92.17	CHANGED	clhphlcphhPhphu..p.sa.Dss.............................GL....ls............pp..........................plp+lhlslDso.pllccAlp......ts.sshllsHHP...l.ha................pshcplssp......htphlhpLlc.s...........sIslauhHTshDss.s.GhNshLA.chL.....slp.........shpsht......................................................................................................................thuhGhl.Gplsp.s....hohpphhthlpppl.th.........tt......lphs.........shspplp.....+VA..lsuGuGs..phlt..pAhptss..D..lalTG-l...........paHsshpA..ppt.....G......ls..llssGHatoEphhhpt.....ltchLppp.ht.......................l	.................................................................................lhphlpp.hhs.phtp..sa..D..s..s..................................GL.....plt.......thcp..........................plp.+....lhsul-soptll-cAlc......tt..sD.hllsH........Hs.......h.ha..............................+s.h.p...s.lt.ss........ptphlppLlp.p.....................................cIslauhHTs..l.......D..........s.......tst..GsNshLA.chL.............Glp..........shp.lp.........................................................................................................................................t.ulGhl.Gplsp...s.........hohtchspplcptL..sh.............ps.......................lchs....................s..sssp...lp.......+VA....lss...GuGp........shlp..pAh.pt.Gs.....D....salTG-l...........................pa+sspsA....hpp........G...............ls......hlssGHatoEph.hhpt.....lschLppt...tt.....................................................................................................	0	349	670	874
+2019	PF03956	DUF340		Membrane protein of unknown function (DUF340)	Bateman A	anon	COG2431	Family	Members of this family contain a conserved core of four predicted transmembrane segments.  Some members have an additional pair of N-terminal transmembrane helices. The functions of the proteins in this family are unknown.	23.80	23.80	24.00	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.34	0.71	-5.01	43	1369	2012-10-02 17:06:44	2003-04-07 12:59:11	8	2	1098	0	227	767	126	173.70	40	69.66	CHANGED	llsslllGhllGhhhhss.....hth..sphsphhLhhLlFhlGlpLtpsshsl+plh.ls++slhlslhslluollGGllsuhlL.slslppuLAluuGhGWYSLSGlllschhus........hhGulAFlsslhREllulhhlPllh+..hsp.suluhuGAToMDsTLPlIppsuGhcssslAlspGhlLollVPlLlshhhu	..................................l.husVllGhhlGhhthsh........lphs...spsSpas.L.hlLLFllGIpLtssu.hoL.+plh.LN++uh..l....lulls....lluSLlGGllsuhlL..s.........ls.lppuLAhASGFGWYSLSGIL.lo-t.aGP........hlGohAFhs-LhREllAlhhIPhLh+...tttss..AluhsGAToMDhTLPllp+.s.GGh.-.hVPhAIsaGFlLollVPlLlshFs.s.....................	0	68	135	189
+2020	PF03959	FSH1	DUF341; 	Serine hydrolase (FSH1)	Finn RD, Bateman A, Mistry J, Wood V	anon	DOMO:DM04042;	Family	This is a family of serine hydrolases [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.56	0.70	-4.89	52	906	2012-10-03 11:45:05	2003-04-07 12:59:11	8	40	298	2	698	2926	1726	210.90	22	69.79	CHANGED	Ms.......t.h+lLhLHGatQouphFptKsuul+KhLpc................sh-hsalsuPh.l..s.schs..........................sttsss.huWahpppt..................tsphhsh--ulchlpchlpc....................................pGP...FDGllGFSQGAsluuhlsshhpphh....................................ppP.h....KFslhhSGFp......ts................................app.........ha...ps.l...phPoLHlhGptDtllstp......+SptLhcthps........splltHsGGHalPsppthhpth	...............................................................................................................................................................h.......+lLsLHGhtps....u...p...hFp.....t...p..h...t..s...l..p..p..tl.pp...........................t.h.chsahsu.P...h.h....s......s.s..h................................................ttsshhs...W..at.tp.tt......................................................tthtsh....p.p.u....l....p.h....l..t...p..h....lp.c............................................................................................p.G.P......a......D....G.......l.......l.......GFSQ.GA.s..l.u..u..h..l.....h...t.h..p.p.h.h...............................................................................tts...h..........+.Fu.l...h.....h...u.G.h.h.s.........hs..t...............................................................................................hpt............hh........pt.l...........ph.P.ol.H.l..h..G...p.........p...D...hls............................t...u.tt....L..h.ph.hps...........stlh.p.H....s.u..G.H.h..l.Ptptt.h...h..........................................................................................................................	0	185	395	577
+2021	PF03961	DUF342		Protein of unknown function (DUF342)	Bateman A	anon	COG1315	Family	This family of bacterial proteins has no known function. The proteins are in the region of 500-600 amino acid residues in length.	32.40	32.40	32.40	32.40	31.80	32.30	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.29	0.70	-6.07	100	994	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	688	0	301	827	74	432.60	19	78.32	CHANGED	lplplusDcMpAtl..........plpss......sGpsl.......................shcclhptLpppsl.shGlpcptlpp...hltp.t.h.........hphllAcGp.PhsGpsuplphhhp.tppph.p.ttccs......plDh+sLsplhs..VptGphLh.c+lPsstGpsGhsVhGchl...sspsG+-htlt..h.G.....pustls.cDsphl.l.AshsGtshht.ps.t.....lpVs...sslplc.sVDlso.GNIp...........................FpG.sVhlpG....sVpsGhpVcAsGcIplt...GhV.-uAplpA.tGsIhlptGllGptp....................uplpA.pGslpspal.ptuplpAtsslhlpctlhpsplpussplhl....ptt+..GpllGGp.hputpplpst..lGu...................ptuspTplpl.uhs.sphpcph..ppLcpplpph...ppphpclppt.......lpth.p.pt.ttp......pthpchtpph....pphppplpplcpchp.plppplpph......tps.plpspc.plasuVplpls...stthphpcp.hsssphhh..psspl	.............................................................................................................h.ht.pth.A.h.........................lh.s......tth.h...........................hhpplhp.hltpttl..hhGl.p....c.....p...tlpc........hhtp.ttt..................ph.lApGhtPlpupsspl.h....hhc...............p..p.t.................ppt..........plD...h.+................p.h.s.hhhs...........Vc.....cs-hlh.ch.h...s.p..p.G.psGhslpGchl........s.hsu...p...-....s.....lh...h.G.......css....ths.......p..-.s...spl..h.As..hsGhshhp..pst........hsVp....shlpls......sV.shpT.GsIc...................................a.p.G.sl.hl.pG......sVtsGhplpAstslplt....Ghl...ppu.plp.A..pusIplppGlhuttt.......................................................................................upltA..ttslh.s....phh.psup.lpAtp....lhlp.phh....h.psplhs.tpplhl................p..stl.u.sp..hpstp.plhsh....lGs.....................th.ss..t.o.p.lps.shp.......phppph....pplpp.p...hpph.......ppth.plppt.........................ltph..p.t............th.p.hpchhpph....tphptphpphptph....plppphpph................................l.h.p.thh.sspl.ht....t....................................................................................................................................................	0	134	239	268
+2022	PF03966	Trm112p	DUF343; 	Trm112p-like protein	Bateman A	anon	COG2835	Domain	The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length.  The C terminus contains the strongest conservation.  Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [1]. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast [2]. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [2].	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.61	0.72	-3.61	69	2406	2012-10-03 10:42:43	2003-04-07 12:59:11	11	10	2242	11	804	1479	422	52.00	41	65.19	CHANGED	chpLLclLsCPhs+G........sL............................................................................p....hchtc.....spLlCpss..phsYPIc-G	....................................ch+LL-ILsC..P..ls+G.............L.................................................................................................................................t....astcp..........pELlC..c..t...s..pLAaPl+DG..............	0	241	477	650
+2023	PF03976	PPK2	DUF344; 	Polyphosphate kinase 2 (PPK2)	Bateman A, Albrecht M	anon	COG2326	Domain	Inorganic polyphosphate (polyP) plays a role in metabolism and regulation and has been proposed to serve as a energy source in a pre-ATP world.  In prokaryotes, the synthesis and utilisation of polyP are catalysed by PPK1, PPK2 and polyphosphatases.  Proteins with a single PPK2 domain catalyse polyP-dependent phosphorylation of ADP to ATP, whereas proteins containing 2 fused PPK2 domains phosphorylate AMP to ADP.\	      The structure of PPK2 from Pseudomonas aeruginosa has revealed a a 3-layer alpha/beta/alpha sandwich fold with an alpha-helical lid similar to the structures of microbial thymidylate kinases [3].	20.40	20.40	20.40	20.80	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.38	0.70	-5.07	10	2990	2012-10-05 12:31:08	2003-04-07 12:59:11	9	6	1855	12	886	2487	1001	226.10	37	80.64	CHANGED	pls+ccYcccLtcLQhELlKLQpWltpcGc+.lVllFEGRDAAGKGGsIKRlT-pLNPRssRlsALsAPT-cEpuQWYaQRYlpHLPAuGElVlFDRSWYNRAGVERVMGFCssppapcFhRclP-FE+MLscsGIhllKaWhuIScEEQhcRFpsRpcsPlKpWKlSPhDlcuRp+W-sYo+A+--MhsRTcTshAPWhVVcADDKK+ARLNsI++lLpulcYpchccs	.................................t..p+ppYcpp.Lp.pLQhc.Lhcl......Q.p..........h.l.......t.....p......p......s......p.....+.....llllFEGhDAAGKGGsIK+lh.p.tLsPRsh+Vsuls............t...P....o-c...Ep.........s............ph.........Y..h....Rah.p+LPs.........sG.....cI..slF..DRSWYsRsh..V..........E.........RV...............h...............G...........a...............s...........o.............p.....p..p.............a.............c....c..........h....hc............plspFEc.hL.s..c.sG.hhl...lKaahplSc-EQpcRFpp..Rhpc..P..h..KpW.K.....l.S.s.hDlcs.pc+W-cYp...pAhccMhtpTsTs.t....APWhllpusDK+.tARlsshchlLpp.l.ch.....h.................................................	0	253	565	757
+2024	PF03978	Borrelia_REV	DUF345; 	Borrelia burgdorferi REV protein	Finn RD, Moxon SJ	anon	Pfam-B_26177 (release 7.2)	Family	This family consists of several REV proteins from Borrelia burgdorferi (Lyme disease spirochete). The function of REV is unknown although it known that gene is induced during the ingesting of host blood suggesting a role in the metabolic activation of borreliae to adapt to physiological stimuli [1].	21.60	21.30	21.60	22.00	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.88	0.71	-4.51	6	40	2009-12-11 17:11:53	2003-04-07 12:59:11	8	1	21	0	4	39	4	144.40	56	92.53	CHANGED	MKNKNIhKLFFluML..FVhuCKsY.............VcEKKcIDSLhpuVSsLNNcsDcspFKsYK-KINcLKEsLKDluNA.ELcEKlLsLpsLFQDKLAAKLAALKAAKscIpuh...sDcDps.sKsKIWocAKLVGVTlhh.GSsToGpGs.......cMSK-AVEQ....IDcIIKFLEEGTN	.........................M+pKNIhKLFFsSML..FlMACKAY..............................................VEEKKpIDSLhpslssLpNctst.....p..pFpsYKpcINcLKEsLKDlGNA...ELcEKLLsLppLFQDKLAAKLAALKA..AKpcIpsh..............TDpDpshsKpcIWuEAKLVGVTlph.GSsosGpGs.......cMSK-AVEQ....I-KIIKFLEEGTN...........................................	2	4	4	4
+2025	PF03984	DUF346		Repeat of unknown function (DUF346)  	Yeats C	anon	Yeats C	Repeat	This repeat was found as seven tandem copies in one protein. It is predicted to be composed of beta-strands. Thus it is likely that it forms a beta-propeller structure. It is found in association with BNR repeats, which also form a  beta-propeller.	21.20	21.20	21.20	21.40	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.06	0.72	-4.50	10	31	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	15	0	18	32	1	39.70	39	21.81	CHANGED	sQQHVauRss-GsLtHWaWs.sssulpppsW..sGsluGsPsA	........VFuRGoDspLtH+WWp.sssuh.s.tsWt.lGGslsSsPsh..	0	8	11	12
+2026	PF03988	DUF347		Repeat of Unknown Function (DUF347) 	Yeats C	anon	Yeats C	Repeat	This repeat is found as four tandem repeats in a family of bacterial membrane proteins. Each repeat contains two transmembrane regions and a conserved tryptophan.	21.50	21.50	21.70	22.00	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.46	0.72	-4.08	170	1475	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	248	0	562	1404	64	55.80	28	80.30	CHANGED	hhaWlshlhopsLGsshGDhLs.c..s...LGlGhssuoslhsullssslshhhtppt...ts	.......hhaWlshlhopslGsshuDhlsc.....s...................LG..l.Gh.s..suohlhsullss.hlshh.hhspt...s.........	1	143	313	454
+2027	PF01796	DUF35		DUF35 OB-fold domain	Bashton M, Bateman A, Krishna SS	anon	Pfam-B_1390 (release 4.2)	Domain	This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins. The domain is approximately 70 amino acids long. The domain is duplicated in Swiss:O53566.  The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain and a C-terminal OB fold domain represented in this entry.  OB-folds are frequently found to bind nucleic acids suggesting this domain might bind to DNA or RNA.	24.20	24.20	24.30	24.20	24.00	24.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.43	0.72	-3.75	157	1861	2012-10-03 20:18:02	2003-04-07 12:59:11	12	19	530	0	752	1722	492	65.50	26	35.94	CHANGED	hhthu.GpGslhoaTssct..sstshh...........PaslulVcL.-..t.........Gs........clhupls........s.s.......ssp......t......lGttVcss.hp	........................hthu.spGslhoaolspt..s.ss.h............Pasl.AlVcL.-...-................Gs............plhupls.........sh.....................ssp.....t.l.t.........lGhpVcssa...........................	0	153	462	641
+2028	PF03994	DUF350		Domain of Unknown Function (DUF350) 	Yeats C	anon	Yeats C	Domain	This domain occurs in a small set of of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues.	20.60	20.60	20.80	20.60	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.36	0.72	-4.23	173	2291	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1116	0	490	1389	176	53.60	26	71.47	CHANGED	asllulllhhlshhlhch.lsP.hchtptIpp...s.NhAuulhhuuhhlulullluuul	................ahhlullh.hllh....hhlhph..ls....P...h..shhphItp..........s..NsAAulh....huushluhulhluush...........	0	138	280	375
+2029	PF03995	Inhibitor_I36	DUF351;	Peptidase inhibitor family I36	Yeats C, Bateman A	anon	Yeats C, Bateman A	Domain	This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C (Swiss:Q9ADK5) and SCO3675 (Swiss:Q9X8V7) also have probable beta-propellers at their C-termini. This family includes Swiss:P01077 a known peptidase inhibitor of known structure. This protein has a crystallin like fold Pfam:PF00030 and is distantly related by sequence.  It is not known whether other members of this family are peptidase inhibitors.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.52	0.72	-3.62	7	93	2012-10-01 23:14:22	2003-04-07 12:59:11	8	5	47	1	33	113	0	89.90	18	54.95	CHANGED	uhtcCPsGthChasussusGphhhs..sssstshGs.hssphtShhNptstssCsat.tsYss.....shhhsthshsRGt...h.sshsuslsuhphlpspptC	.......sCssGphClassss..asGshhpht....sss..............h.s.....s...h............s.s..........h....ss.p.sp..Shh.Np.osttsshYpptsats...........................................h.h...............................................	0	10	25	33
+2030	PF04001	Vhr1	DUF352; 	Transcription factor Vhr1	Finn RD	anon	DOMO_DM06473	Family	Vhr1 is a transcription factor which regulates the biotin-dependent expression of transporters VHT1 and BIO5 [1].	25.00	25.00	47.90	46.90	22.50	20.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.08	0.72	-4.07	6	53	2009-09-10 17:29:09	2003-04-07 12:59:11	8	1	38	0	31	51	0	94.00	66	16.65	CHANGED	spchothGsTH+IREpLNFsDEKKWKpFSSRRLELIDpFsLSp+KASEQD-NI+QIAshLRsEFsYPspsop-FEKLVTAAVQSVRRNRKRSpKpp	....t.p.su.GsTH+IR-pLNFpDE+KWKpFSSRRLELIDpFsLSp+KASEQDpNI+QIAsILRsEFsYPsohosEFEKLVTAAVQSVRRNRKRSpK+.h.	0	5	19	30
+2031	PF04007	DUF354		Protein of unknown function (DUF354)	Bateman A	anon	COG1817	Family	Members of this family are around 350 amino acids in length. They are found in archaebacteria and have no known function.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.11	0.70	-5.57	4	167	2012-10-03 16:42:29	2003-04-07 12:59:11	7	3	126	0	117	350	205	320.30	24	90.78	CHANGED	h+VWIDIsNuPHl+FF+slIpchc+cGh-lllTsRchGslscLlchhGFphpsIGKHG.sTLpcKLltsucRshtLochIspp+PcVulhKpshELPRlAFGLpIPSIhllDNEpAlstNKLhhP........LscpllhPcshDt.clhchGuD.N.Ip.apGhsElsslps.....a..-splLccLs..hccpphIVMRPEP.tuoYhsu..+cSILscIl-hLpchss..IllhPRsccQ+EIacta-.lhIPccslDsLoLhahuchhlGAGGTMNREAAlLGsPslSsYPGK.LLuVDKaLI-pGhhaHSsDscEIlp....hVhsNhthR+tl+sh....-c.hchIl-hVpshhc	..............................................................................................................................................lhlDlspss.al+hF+thlpcLcc.c...G...a.-..lh..l..TsR...c...h...s...pshc...LLc..ha..sl..sa...h...s..lG.p..pu....ss...hh.......tK...lht....h..p....R.....t.h.p.Lh.ch...h.p..p..............h.c...P....Dlhl.u.h....s....u.sp....s...s....+.l....u.hs...ls..h.....Psl.....hh.......hD.........s.........-...tu.....h..h................s+L.shP.............hssh.ll....sPtsh................htp..h...Gtc...p.lh..asG...hp..Ehsa.l...p.s............F.p.P.c....t...s.llc..c.LG.....lc...s.p.t..a.l..l....l...R..p.s.h...p.A.s.Y.sss.........pp..sl...h.........c....l..l...ct....Lp...c.h..sp...l.V..h......l....s...cp......p....p......p.....t..p........h......h........c.........p.......h........p....h......h........l..s.......c..s...l........c...h...h...s...Ll...ha...uclhlusGu.TM.spEAAl..LGsPsl...p...h...h.s.........h..pp.h..h.hp...t.h.h.hh..p......t...h..................................................................h............................................................................	1	28	75	96
+2032	PF04009	DUF356		Protein of unknown function (DUF356)	Bateman A	anon	COG1844	Family	Members of this family are around 120 amino acids in length and are found in some archaebacteria.  The function of this family is unknown.  However it contains a conserved motif IHPPAH that may be involved in its function.	29.50	29.50	30.40	115.80	25.00	29.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.37	0.72	-3.97	10	49	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	49	0	39	47	1	106.90	43	82.18	CHANGED	lllIRADshcKlpsALuDL-RauulpItGKPRIlsPshADcllppllGp.lR++s+sAsLVcl-pssscAIs+lR+IHPPAHllVlSsRa.-sYp-Lhcpas+h.cL.+	llLIRuDsa-KlpsALADlcRautlpItGKP+IIsPphADpllcpIlGp.l+KpsKsAslspl-psAs+AIsRlRKIHPPAHIlVlSsca.-sapcLhcpasphP.LK..	0	7	15	28
+2033	PF04010	DUF357		Protein of unknown function (DUF357)	Bateman A	anon	COG1849	Family	Members of this family are short (less than 100 amino acid) proteins found in archaebacteria.  The function of these proteins is unknown.	24.00	24.00	24.00	35.20	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.36	0.72	-4.28	41	162	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	151	2	105	158	72	71.80	33	50.27	CHANGED	c+Yhchlc-ALpplc........ts.httssc-hlchAcsYhcDu+aalc.pGDhlsALuslsYuaGhLDAutclGlhs	.............................+Yhchhc-ALpplc........t..htsssp-...h...lphAcsYhcDu+aahc..cGD..hlsAluslsYAaGhLDAstplGlh......	0	25	64	86
+2034	PF04019	DUF359		Protein of unknown function (DUF359)	Bateman A	anon	COG1909	Family	This family of archaebacterial proteins are about 170 amino acids in length.  They have no known function. The most conserved portion of the protein contains the sequence GEEDL that may be important for its function.	25.00	25.00	52.30	51.60	22.80	18.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.41	0.71	-4.73	31	147	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	144	0	99	150	82	122.20	34	69.31	CHANGED	VTp....sllcsGltPtlsllDsKT+Rp.hpppht......htphlpVcNPsGsIo.-llcslccu...htp.scsshIhVcGEEDLhslPsllhAP.s.ohVlYGQPs.pGlVllpVspchKpcspcll.cchptp	......sTtpllcsGlhPslullDtKT+Rp.spppht...........hhtphlcVpNPsGsIot-lhc.slcpu....htp...spsshlhVcGEEDLhslPsllhAPtG.sh..VlYGQPs.cGlVllpVspchKpcspcll.cphp..h...............	0	24	58	80
+2035	PF04021	Class_IIIsignal	DUF361; Type_III_signal; 	Class III signal peptide	Bateman A, Szabo, Z	anon	COG1991	Motif	This family of archaeal proteins contains.  an amino terminal motif QXSXEXXXL that has been suggested to be part of a class III signal sequence. With the Q being the +1 residue of the signal peptidase cleavage site [1]. Two members of this family are cleaved by a type IV pilin-like signal peptidase.	23.50	23.50	23.60	23.60	23.30	23.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.85	0.72	-7.04	0.72	-4.10	49	226	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	58	0	144	226	10	27.60	32	22.13	CHANGED	p+GQlSlEahlLlhulllsshlsshhhs	..p+GQlSlEahlLlhullllshlsshhh.........	0	19	44	103
+2036	PF04015	DUF362		Domain of unknown function (DUF362) 	Kerrison ND, Finn RD	anon	COG2006	Domain	Domain that is sometimes present in iron-sulphur proteins.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  --amino -o /dev/null --hand HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.45	0.70	-4.85	115	993	2012-10-02 00:55:42	2003-04-07 12:59:11	7	22	485	0	449	1069	99	221.70	23	62.70	CHANGED	+VllKPNllt....sps.Pp........ussTcPpllc.ullchl.t.ctGu..p..lhluDusuhs.......ssppshcpsGhtphsc....chGs..pllshspst.hhthtt............sthhpphtlspslh-.u..DhlIslPpLKsHshst.hThulKNhh.Ghlss................pKst...hH............................................................................t.pphsphls-lsph.h.....pPsL..sllDulhu....hpusGP.s.sGpsh....ph.sh.llAusDsl.AlDss.uspll	........................................................................................................................VhlK.phsp..........ts....................tshhcPthlcsll.chl..p..ph...G..u...p...hlssssshhs..................pthps..ht.tsGhp..hst..............s.s......tl.l......hc..s...phhp.h.h..................tsphhp.php..l.upslh-.....u.......DhlIsls+hK.s.Ht.h...ss....hsuulKNlh.Gssstt..................sKtt......hH........................................................................................ttpth.t...ctls-hsps.l...............+sph.........s.l..h.....ssl.hs.......h.s..uP...s...ssp.st..............hh..sl.lhAS.tD.sV.AlDtsssch........................................................................................................	1	226	385	422
+2037	PF04016	DUF364		Domain of unknown function (DUF364)	Kerrison ND, Finn RD, Eberhardt R	anon	COG2014	Family	This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, Pfam:PF13938.	23.00	23.00	23.40	24.20	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.52	0.71	-4.88	60	351	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	267	6	183	356	38	129.70	21	50.59	CHANGED	ss.h-h.hthttsccVslVGt.......a.P..hlctlc.p...pstplhllEhsst....tth.h....ssttsptlLspsDslllTGoollN.pTl-pLLphsp..sstllllGPosshhPtshhshGlshluGsh..lhDs-tlhcslscGuustthpttsththhh	...............................tsp+VsllGh..........h.P..hlcplt..t.......tstplhlh-hss...........t.tphsh.................ssptsptllsp..sDhlllTGoollN.sTlsplLphs.c.....s..t.h.h..llhGPos.shhs.hhhthGhphlsu........p...hh.hh...................hh..........................	0	77	130	159
+2038	PF04033	DUF365		Domain of unknown function (DUF365)	Kerrison ND, Finn RD	anon	COG2028	Family	Archaeal domain of unknown function.	22.50	22.50	22.80	89.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.33	0.72	-4.00	5	11	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	11	1	9	15	0	94.70	52	69.01	CHANGED	MKlIFYASREDQGFaGEAEIERVEha-sPhcIlEKYGDcLFLTcEELK+Y.E+upcRWsu.....cu+RKRPWMVIcL+NIRKYc+VVKPKRFVPVuGRYV+E	.MKllFYASREsQGahGEAElEpVchapss.cIlcKYtDcLFLT.EElRcY.p+s.pcRWss.....tu+R++PWMVlhL+NIRKYs+VVKPKRFlsVuGRYl+-.	0	4	5	5
+2039	PF04017	DUF366		Domain of unknown function (DUF366)	Kerrison ND, Finn RD	anon	COG2029	Family	Archaeal domain of unknown function.	25.30	25.30	25.80	170.30	23.40	25.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.95	0.71	-5.01	15	67	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	66	6	53	69	18	186.10	43	97.22	CHANGED	M....hhlll--cl-YDGSQIpShWAapsFGlpGDSIVsFRGsC-Vch-cMlDlEDl+pcp.....IpScDMlHFIlEHFDp...DLchuhtRQRLLlull+EhLpch......GlcspRcGDDLYlss+KLSVSIATsSsVShKIHhGINVpocGsP..VsslGLpD....LGlcshp...plhccluppYscEh-cIc+DhpKsRs	............hlhhccplcYDGSpIpshWAacsFGlpsDSIVsFRGsscVcl-cMlDlcDl+tpp......IpSsDMlHFIlEHFDp...DLchshhRQRLhlsll+ElLpch......Glc.hpRcGDDLYhs....s....+KLSVSIAosSsVStKIHhGINVpscGsP..VpslGLp-.........lGlpshp.....clhccluptYscEhccIc+DhpKsR...	0	14	28	42
+2040	PF04034	DUF367		Domain of unknown function (DUF367)	Kerrison ND, Finn RD	anon	COG2042	Family	\N	23.80	23.80	24.20	29.50	22.90	23.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.59	0.71	-4.53	10	466	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	417	0	327	458	69	125.70	45	45.79	CHANGED	lVLoPhuctslSPcD+-ll-+pGlsVlDCSWs+l-ch.Fscl+s...cptRtLPaLVAANPVNYG+PtcLSolEAlAAsLYIlGhh-cAptLLS+FpWGcsFL-LNcELL-tYupscsS.EIhclppcaLp	..........lVLoPh.uppslSP.s.D.+pl....lppt.GluVlDCSWs+l..--...s..PFs+lpu.......p.p...R..LLPa.LVAANP....VNYG+Ph+LsCVEAlAAshhIs..G.ap-hApp.lLspFpWGcsFL-lNc-LL-tYutC.p.sspElhpsppcaL..............	0	111	190	275
+2041	PF04018	DUF368		Domain of unknown function (DUF368)	Kerrison ND, Finn RD	anon	COG2035	Family	Predicted transmembrane domain of unknown function.  Family members have between 6 and 9 predicted transmembrane segments.	24.90	24.90	25.50	27.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.75	0.70	-5.19	110	1391	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	1306	\N	249	911	878	250.90	32	87.16	CHANGED	M..GuADlVPGVSGGTIAhIsGIY-cLlsuIssls......phhphhhp...........tthtthhpthsh.FLlsLhhGlhhulholupll..saLLppaP...lhsauFFhGLIluSlhhlh+.p......................lpt..hshtp...l....lhhllGh.sluhh........ls...............................h........hsss.p...sssshhh..........................lFhuGhlAlsAMILPGISGSFlLLlLGhYssll.sAlpsh..........................slshlhlFuhGsllGLlsFo+lLpalLc+a+shTluhLsGhhlGSLttlW.....Pap.............t..hshhp...tslhshsa	............................hGhusllPGVSGGTlAhllGIY-chIsuluplh..pthc.hhp............................sh.FLlslhlGhllulhhhSpll.......paLLps........a....l.shhhFhGlIluolPhll+p.................................tpp.....hshtc........l..hhhl..h..uhll.s.hh.hs...................................................................................................h.................hssh.t...t.hssshlh.............................................................................................hhlAGhlAusAMlLPGlSGShlLLllGlYsshl.sulpsh..........................tLshlhsh....uhGslsGllshSKllsahLp.+a+shshthIlGlllGSlhhlh.....Phh..........................sss..h.hh.h.hh..........................	0	76	167	220
+2042	PF04126	Cyclophil_like	DUF369;	Cyclophilin-like	Kerrison ND, Finn RD, Eberhardt R	anon	COG2164	Family	This domain has a cyclophilin-like fold, consisting of an eight-stranded beta-barrel with an alpha helix located between the beta-2 and beta-3 strands and a 310 helix located between the beta-7 and beta-8 strands. The catalytic site found in human cyclophilin is not conserved in this domain, suggesting a different function for this domain [1,2].	20.30	20.30	20.30	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.60	0.71	-4.51	14	235	2012-10-02 15:38:38	2003-04-07 12:59:11	8	5	223	5	81	217	103	113.10	22	69.69	CHANGED	h+l+Ihhs.....ptcs.sELs-s...pTsctlhcuLPlcupsspWG-ElYFosslpss.-Esup-sV-hGDluYWsPG+AlClFFGsTPhS.ssc.pPASsVNlIGRlsssh.chlppVpcGspVtlc	.......................plclphs.....spphpupLt-s...tsucphhptL...Plsl.p.h.p.p..a..G..s..E...h.h.h..ph...Pt.p.l.s.hp.ss........s..t.s.s.s.p.sGDlsYasstss.....lslFY.tpt..............t.h..hGch.ts.........h................................................	0	35	56	71
+2043	PF01809	Haemolytic	DUF37;	Haemolytic domain	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1485 (release 4.2)	Family	This domain has haemolytic activity [1]. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	21.10	21.10	21.80	21.10	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.35	0.72	-4.36	219	3575	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	3453	\N	886	2340	1979	65.50	47	72.84	CHANGED	hppllltlI+hY....QhhISPl.h.s.ss.CRFhPTCSpYul-Alp+aGsh+GsaLulpRllRCHPa....ssGG.aDPV	....................pplhlthl+hYQth..I..SPl....h......s.....ss..C...RF.....h.....P.....TCSpYul-Alp++GshKGsaLultRILRC.HPa....stG..G..hDPV..............	1	320	605	769
+2044	PF04025	DUF370		Domain of unknown function (DUF370)	Kerrison ND, Finn RD	anon	COG2052	Family	Bacterial domain of unknown function.	21.20	21.20	21.70	21.50	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.12	0.72	-3.93	19	534	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	505	0	164	344	8	72.70	64	81.98	CHANGED	LlNIGFGNhVsusRllAIVsPcSAPlKRlhp-A+-pupLlDATpGR+TRAVIlhDSsHVILSAlQPETlupRl	.......LlNIGFGNIVSAsRllAIV...SP....E....SA....P....IKR....llQEAR-+GhLIDATYGR+TRAVIlhDSsH..VI.LSAlQPETlApRl...........	1	85	138	153
+2045	PF04027	DUF371		Domain of unknown function (DUF371)	Kerrison ND, Finn RD	anon	COG2090	Family	Archaeal domain of unknown function.	25.00	25.00	44.10	28.20	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.60	0.71	-4.49	19	131	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	127	1	86	127	18	128.60	38	81.94	CHANGED	l+A+GHcNVpApH+SThElT+DcaLTPpGDCIIGlsAD+uhsDlsccFKptl+cscth.lplhlcs.....sshpDplhGpGpscLoLscssshVhR+SsYl.ssRTlhIpAsKAAtDlsR-llctL+.cGsplhlplhV	..........lpu+GH.NVpApH+oTlElT+-saLTspGDCIlGlsAD+uhtDhspchKptl.psspt..lhlhlcs............ts.hh-hlhGpGsscLsh.spspclVhR+Ssal.ssRTlhlpAsKAApDlsR-llptL+.sssphplpl.....................	0	23	51	72
+2046	PF04036	DUF372		Domain of unknown function (DUF372)	Kerrison ND, Finn RD	anon	COG2098	Family	Domain of unknown function.	20.40	20.40	21.00	40.50	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.65	0.72	-4.49	15	84	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	82	14	60	90	6	38.00	56	31.52	CHANGED	ERAhFEAGIKLGALYHQFsGTPVu.coAsSLEpAIE-S	..EcAsFEAGIphGALaHQFsGTPVS...coscSLEpAIE-u..	0	11	41	52
+2047	PF04123	DUF373		Domain of unknown function (DUF373)	Kerrison ND, Finn RD	anon	COG2237	Family	Archaeal domain of unknown function.  Predicted to be an integral membrane protein with six transmembrane regions.	22.10	22.10	22.20	22.20	21.50	21.90	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.98	0.70	-5.42	35	156	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	130	0	101	157	110	341.20	29	93.44	CHANGED	M.chLVlsVDRDsDlGcKsGlpTPVlGR-sslcAAlcLulsDPEDSDsNslFuul+lY--Lc...sc.Gc..-VEVAsloGspcs.ulpuDhplucpLDpVLpphsss...ssllVoDGu-DEpllPlIpS+l.lsuVcRVVV+QupslEoTYYll....KcslsDschpphhL.lP.GllLLlaulhtlhsh..............sshslsslshllGhahLh+Ghul-chlpphhcphhtsh..t.clohlohlluhhllllGlltGhhsl.phtshsshhhhs..........alhshl.ahshuslh.shlG+ll-phlpschphhphlst.hhlhuhthllashssah.hs............hhhsslphhhhslssslllulhs	.....phLVlsVDhDDDlGcKsGlpoPllGR-sshcAAscLulsDPEDSDsNslasul+lYD-Lcpc...Gc..-VElAsloGspcs.ulpushplucplDplltphsss...tsllVoDGs-DEpllPlIpSRl.lsuVcRVVV+QucslEoTYYll....KchlsD.chpphhL.lP.GllLLlaulhtl.hsh..............sshshsslshllGhahl.h+Ghul-chlpphhcph.......h..G.plohlohlluhhllllGhltuhhtltshtsttshhhhs.................alhshlsahsh.uhlh.h.hG+ll-phlpp..ch.phhphlst.hhl...lulhhllhs.hsthhhsh.....................h.hssh.phhhhhlsshlllul..h.......................................	0	23	61	85
+2048	PF04028	DUF374		Domain of unknown function (DUF374)	Kerrison ND, Finn RD	anon	COG2121	Family	Bacterial domain of unknown function.	26.00	26.00	26.80	26.20	24.30	25.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.39	0.72	-4.74	79	649	2012-10-02 00:16:30	2003-04-07 12:59:11	8	4	572	0	167	448	385	78.70	34	33.22	CHANGED	hhshha..tp..........tphtsllSppcDG-llupslcthGhpslRGS..........os..+GGspAltphlctlc.pGtsl..ulTPDGP+GPtc	.......................hshha...tp...........tchhshlScpcDGEllApllcph.GhpslRGS............os+GGspALpphhctLc..pG..p.sl..slTsDGP+GPh......	0	71	123	147
+2050	PF04041	DUF377		Domain of unknown function (DUF377)	Kerrison ND, Finn RD, Mistry J	anon	COG2152	Family	This family contains many hypothetical proteins, some of which are predicted to be glycosyl hydrolases. This family was noted to belong to the Beta fructosidase superfamily in [1].	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.06	0.70	-5.71	8	965	2012-10-02 00:26:57	2003-04-07 12:59:11	8	6	499	13	330	923	112	286.00	27	80.25	CHANGED	hh+KhPs.PIlc.Po.hpGaDs+h................sFNPuVl.hcpch.....hVhlYRsps.cshsohRIGLuhSpDG......lpastcPEslhhPchphEhhG...lEDPRlsKlsccYhMTYTGhss+hsRlsluso+shloat+hs....shhs.Fshp....phho+sGslhPpKl.....sGcYlMaa+........sushaLAhS..sDtlpW-shhcs....lh..pscpsha-s...lKlGsGsPPlcsp-G..LVLhH...sss...s-phlYRlGsALhDt-sP.+...llhRocp.ILEPEt.aEhaGcVsNVVF.ssu.hV-ts.t+lllYYGuADptlGLAphs..lcclhchscc	................................................................................................................hh......................................................hhNsu...sh..httt..........................hhhhhRs............p....s........t.....t......h........h.................................hl....thu...S...pDG........................l.p.a.p.h......p....c...P....l...h..h....P...p....s.....p.............c....t.....h.....s......................h.DsRl.s..........t..h.....-....-.....t.....Y.....ah....sa.s...........u...........h...........s........t...........p...........s...........s..p..........h....u............l.u.........t.........o....p...D.h...t.....s...apphs..................................hh..s....s....................................+..ss....s..LF..P.c.........+l..........sG.....+.Yh.hhpR..............................tslalu.h.S..........sD........h.h.t.......W......s......t...p.pp.........................lh....ps.p..........t...h.a..cs.............h+l....GsGssPIcT.........p....c.......G.....WLhlYH.G......s....................sss...h.....t..Y...shGsh..L.L..DlccPs+.....lltRspp.llt..Pp....t......a...E..........p.......G...........V.s.N...VVFssus..l.........h.......c........t.......c.....p.lh.lYYGsADoh..hulAhhp..lpcllp....h.................................................................	0	164	266	307
+2051	PF04070	DUF378		Domain of unknown function (DUF378)	Kerrison ND, Finn RD	anon	COG2155	Family	Predicted transmembrane domain of unknown function.  The majority of the family have two predicted transmembrane regions.	25.00	25.00	32.20	32.10	24.30	22.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.00	0.72	-4.35	26	729	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	606	0	136	385	24	60.70	43	82.79	CHANGED	M+slshluLlLlIlGuLNWGLlGl..FpaDLVAulFG.Gps.....oshoRllYlLVGluulaplh.hhp	.........hphlphluLlLsIlGulNWGLlGh.....F..pFDLVutlF...Gss.......ohluRIIYhlVGluulYslhhh..t....	0	54	99	112
+2052	PF04038	DUF381		Domain of unknown function (DUF381)	Kerrison ND, Finn RD	anon	COG2098	Family	Archaeal domain of unknown function.  Strongly conserved YPLM motif.	25.00	25.00	32.00	31.60	16.90	16.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-8.89	0.72	-3.93	21	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	85	14	63	93	5	60.00	33	50.59	CHANGED	lpslsVcIcpshlcsphs..au.YoELsGcMLcVclplcYsusplpsphca..Eh-YPLMhlcc	..............scclpVcIcp-hlcppht..hu.YopLsGcML-Vclplch..psspstsplca..EhsYPLMhlc......	0	13	44	55
+2053	PF04063	DUF383		Domain of unknown function (DUF383)	Finn RD, Kerrison ND	anon	DOMO_DM06609;	Family	\N	23.50	23.50	23.50	23.60	22.10	23.40	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.26	0.71	-4.76	31	308	2009-09-11 22:59:18	2003-04-07 12:59:11	9	8	266	0	219	301	3	182.50	32	50.38	CHANGED	hsplsc.pps....ADhh...shLLuNLu+s-shsp.llshppp...............................................pth.tsppsl-pLhDsFsKGhp........................................sshN+..cAsaDYLuhlFAslS+hccGRpaFl...........................scQch-t.l.PlsKLlsFTE+t.SplRRcGVAoTIKNssFDtstH....hLLs.....--t.................lslLPalLLPlA.GsE..EhsE.E-hhsLPs-LQ..hLPsDKcR-sDssIhph	...........................................................................................h...lhp.pp....uc.hshlLuNLs+.t-shtp..llpht.pp..........................................................ps....hslspLhcsFsp......................................................tshNc..push.cYLu.lhuslSphtpuRpahl...........................sppchs...........lp+LlsaTcpt...SplRRt.GVsuTl+NssF-tppH....thLLs.......pp................................lslLPalLLPlu.GsE.................-hs-.E-h..tphPs-LQ..hL.P.-K..pR-sDssIhh.................................................................	0	72	119	184
+2054	PF04064	DUF384		Domain of unknown function (DUF384)	Finn RD, Kerrison ND	anon	DOMO_DM06609;	Family	\N	20.40	20.40	20.50	21.00	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.90	0.72	-4.40	29	294	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	252	0	203	282	2	57.90	36	15.57	CHANGED	oLhLLssT+pGRchhRs+sVYsIlREhHph....p....p-.cclt-sC-+......lVplLhRcEsptsh-p	......slhLLssT.+tGRchlRstslY.IlREhHph.....E...................p-...ppVtpuC-+...............lVplLhp-.E.tts................................	0	72	116	170
+2055	PF04074	DUF386		Domain of unknown function (DUF386)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family consists of conserved hypothetical proteins,  typically about 150 amino acids in length, with no known  function.	20.10	20.10	20.50	20.50	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.79	0.71	-4.70	13	3287	2012-10-10 13:59:34	2003-04-07 12:59:11	7	3	1492	8	258	1385	24	148.30	31	97.21	CHANGED	M.Iluclsphshhhuls.tlpcsl-aLpspshssLssG+a-IcGDplahsVhphpTpsssscphEsH++YlDlQlllpGpEpItaussht..shps.psas-pcDltahtsscscptlpLpsGpFslFaPt-sH+Ptshsss.sppl+KlVlKVtls	....................................................................M.Ih.splp.p..h...p....h....t...l..sst.lpcu..l....-..a..l.ps..........p......t..hs....sht.s...G...+..h-..l.....c...........G...c.plFhpl...p...p..Tp.s.st..p..pp.hEhHc+YlDIQllL.p.G.p.E.t.hsaussss...st...ps..ps.a.pc...-cD.l.t...a.h............s........s..p...s.....E...p..hl..t.L..p.....s..GpFs.lFaPt-sH+Ptsh.s..s...p.....s.......t.......t.......l..+KlVlKVth.t.........................	0	59	125	184
+2056	PF04079	DUF387		Putative transcriptional regulators (Ypuh-like)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family of conserved bacterial proteins are thought to possibly be helix-turn-helix type transcriptional regulators.	27.40	27.40	27.90	27.80	27.00	27.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.71	0.71	-4.86	139	3001	2012-10-04 14:01:12	2003-04-07 12:59:11	11	3	2904	3	769	2172	2160	158.50	36	73.66	CHANGED	shlEAlLFsuuc...P.lolppLsplh...........s...tsplpphlpcLppcY..................ttps+.Glplhch.ussaphtT+schuphlpchhpp..t..tcLSpAuLETLAlIAY+Q.PlTRu-I-plR.GVs.usshlppLhc+sLlcptG+pcs.sGRPhL.YsTTcpFLchFGLps..Lc-LP....sl	...........................t.hlEAlLFs...uu-...s.lshcpLscllt....hs...............splpphLpcLtpcY.......................................p.s.p..GlpLhcs.us..saphtT+schuphlpch.hpp......t...ptpLSpAALETLAIIAY+Q.PlTRu-I-p...IR.GVs...ossslppLht+sLIcts....G.....+p.-.s....sG..RPhL...YsTTctFL-hFGLps.Lc-LPs...................	0	268	528	663
+2057	PF04076	BOF	DUF388; 	Bacterial OB fold (BOF) protein	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Proteins in this family form an OB-fold.  Analysis of the predicted binding site of BOF family proteins implies that they lack nucleic acid-binding properties [1].  They contain an predicted N-terminal signal peptide which indicates that they localise in the periplasm where they may function to bind proteins, small molecules, or other typical OB-fold ligands [1]. As hypothesised for the distantly related OB-fold containing bacterial enterotoxins, the loss of nucleotide-binding function and the rapid evolution of the BOF ligand-binding site may be associated with the presence of BOF proteins in mobile genetic elements and their potential role in bacterial pathogenicity [1].	23.60	23.60	23.70	23.90	23.50	23.50	hmmbuild  --amino -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.10	0.72	-4.20	7	1522	2012-10-03 20:18:02	2003-04-07 12:59:11	8	1	890	1	148	625	10	102.00	40	81.34	CHANGED	uhs...........tGGFpGss.sstsoVctAhphtDDs.VsLcGsIlcplscDhY.FRDsoG.pIpl-IccphasG.plpscshlpIpGclD.+chsps-lDVctlpK	...............................ttts.......s.s.ps.tsG..ap..G..ss.....u.ph..h..T...Vcp...A...K..s...h...+D-sh.....VoL+GNllc...+l..u...-DpYlF+DsoG.pIsV-IDcc.ha...s...G.h.s.VsPc.spVcIpGclD...Kc.h..s.s.s.cl-VcplpK...................	0	16	45	102
+2058	PF01837	DUF39		Domain of unknown function DUF39	Bateman A	anon	Pfam-B_7373 (release 4.0)	Domain	This presumed domain is about is about 360 residues long. The function of this domain is unknown. It is found in some proteins that have two C-terminal CBS Pfam:PF00571 domains. There are also proteins that contain two inserted Fe4S domains near the C-terminal end of the domain.  The protein Swiss:O26943 has been misannotated as an inosine monophosphate dehydrogenase based on the similarity to the CBS domains.	25.00	25.00	42.10	41.80	19.00	18.70	hmmbuild  -o /dev/null --hand HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.94	0.70	-5.79	75	219	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	176	0	141	228	13	356.80	43	84.63	CHANGED	AlVlTAEEhhshVc-.GhppssccVDVVTTGTFusMsSSGAhlNhGa.o-PsI+h..p+saLNGVsAYuG......luAVDsYlGATphs-pss................pYGGGHVIcDLluGKplcLcApuhsTDCYPR+pl-splTl--lspAhLhNPRNuYQNYssulNsu..-+sl.aTYhG..sLhPphGNssYSsuGpLuPLhND......PthcsIGlGTRIFLGGutGYlshpGTQHss.........Phssh.uTLhlhGDhKpMsscalRGshhpuYGsoLhlGlGlPIPlLsE-lhptsulpDcDIhsPllDau..hsppsRs.slutVoYu-L....................................................................+SGpI....plpG+cV....p.TuslSShthAcclApcLKchIppGcFhL	.AVVlTAEEhhphVc-.GhppuAc-VDVVTTGTFusMsSSGAhlNhGH.o-Psl+h..p+saLNsV.AYuG......luAVDhYlGATphs-sss................cYGGGHVI-DLl.uGKplcLcApuhuTDCYPR+pl-spIol--lNpAhLhNPRNsYQNYssulNsu..c+sl.aTYhG..sLpPphGNssYSssGpLSPLhND......PthcoIGlGTRIFLGGu.GYlhhpGTQHsPt...........ssh.uTLhlh.GDhKpMsscalRGshhpuYGsoLhlGlGlPIPlLNE-lhptsulpDcDIhsPllDau..hPpps+s.sluhVoYu-L..........................................................................+SGpI.........plpG+cV......TuslSShhhAcclApcLKpWIppGcFhL..................	0	48	104	129
+2059	PF04094	DUF390		Protein of unknown function (DUF390)	Bateman A	anon	Pfam-B_1698 (release 7.3)	Family	This is a family of long proteins currently only found in the rice genome. They have no known function. However they may be some kind of transposable element.	19.60	19.60	19.60	19.60	19.10	19.40	hmmbuild  -o /dev/null HMM SEED	828	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.48	0.70	-13.45	0.70	-6.49	2	813	2009-01-15 18:05:59	2003-04-07 12:59:11	9	20	6	0	486	813	0	267.70	29	75.06	CHANGED	MRTaQGhpWDWsPEDF+hlVQRVLNLsSVEASLIPQtlLPLCsDP-RAsILTIM.tVGAStERA.+GHDGAGGSRRGEQSTPGGGRASGsRDtGPGuSRPADARGKRKQtGTPsPSPPRGGGAVRASSRRPEGAsPTSQPEGERKKKRhpKMGtsp.utGs..p..thph...................................h.shSEIPSRPSRHSKSGpSEAE-sAsAEARRREuDRREAADRLREAEEAAQ-AsRsRQAEEsAREEA.RhRpAtEusRE.cAu.RtcpAh............sp.uPsPossttsTTStAstDEAAGs.LGPsPSGDA.DpPusGshP-SGTSIGGPSRAAsoPRRL..hPShAPLsAEPLLQALAAsNTTVLDGLSAQhEsLQAERAELDAAWARVEEGRRSVEAMVEhGRKAHRRHsSELEsR++sLAEIA+EVEEERtsALIATTVhNEspDsLRLQYGShtAELcKKLDAApGVLDAAAAREpRAAEsEAASRpRE.ALEARAhALEERApshERDhADREAAVsIREATLAAHEAACAEEE.ALRLREDsLTERtRuLEtAEuAAQpLADSL.LREAApEEQARRNLEGARAcRAALsQRsAELEARAKELDARA+SGGAAsG-uDLAARLAAAEHoIA-LQsALDSSAGcVEALRLAGEVGPGMLhDAVSRLDpAGRQsGLWtGRssKYAANQGGLAQRLScMAGsLQRLPEELEcTIKSSSRDLApGAVELVLASYQARDPsFSPWhAL-EFPPGTEDusRAQVRDAAspIVcSF-GoAPRLsFA.sSDEEGsssGAsDuDDEAGDPGAS	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1	1	1
+2061	PF04134	DUF393		Protein of unknown function, DUF393	Mifsud W	anon	COG3011	Family	Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	25.60	25.60	25.60	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-11.11	0.71	-2.97	156	1577	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	1266	0	502	1346	1808	108.70	23	68.72	CHANGED	llaDGsCsLCstts..phltct.....Dp.t........t...plpassl....psststphh...........................t..s.ls..hpphpsh........lh....tsp...........................hh.ps....scAhhpl.hptlsh...hthlthhhh..lPth..ltchhY.phlAcpRaphhup	...............lhaDGsCshCsshsphlhpp......Dt.t.........t..phpassl..........psptstp..h...............................................................tt.s.ls......hpphpsh..........lhh...pssp.............................haht....ssA.hhpl..hp.....t..lst.......hphl.s.....hh.hh....h.....Phh....ltchsY.chhApsRhch..............................	0	152	315	430
+2063	PF04143	Sulf_transp	DUF395;	Sulphur transport	Bateman A	anon	Pfam-B_2577 (release 7.3)	Family	This is an integral membrane protein. It is predicted to have a function in the transport of sulphur-containing molecules [1].  It contains several conserved glycines and an invariant cysteine that is probably an important functional residue.	22.00	22.00	22.10	22.00	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.05	0.72	-3.93	106	5952	2009-09-11 12:44:05	2003-04-07 12:59:11	9	11	2209	0	1539	4246	1254	43.90	30	23.66	CHANGED	hhthllG.GhlhGhGhtluuuCssushhssssshsh.uhlshhuh	.............tsllG.GllhGhGhsLAGGCssGshhsussshsh..uhlshls.......................	0	487	974	1295
+2064	PF04148	Erv26	DUF396; 	Transmembrane adaptor Erv26	Wood V, Finn RD	anon	Pfam-B_22900 (release 7.3);	Family	Erv26 is an integral membrane protein that is packed into COPII vesicles and cycles between the ER and Golgi compartments.  It directs pro-alkaline phosphatase into endoplasmic reticulum-derived COPII transport vesicles [1].	22.20	22.20	22.80	22.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.64	0.70	-4.96	19	254	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	225	0	176	237	4	186.10	38	87.32	CHANGED	M.lL.LLuYlGsllGFsFLTLuIASGLYYlSELVEEHo..s+RhLpRhIYslIslhlLLhlhDpFPapLolhSIsoahVYhpNL.+cFPhlpLouPhFllSClLVllNHaLWFcaFsp..........s...s.php.....Y.....t....hsoFsEVsSaFulCVWlVPFALFVSLSAuDNVLPotspptsstt.............................s..t...+p+spGLhKsllsslRchl	.....................M.hl.llualuhhlthhFlTLul..................A......uGLYYLuELlEEaTshs+RllphhIahhhsl.hlhLhlh-pFPhh.hsh.hulhopllYht.L..ppFPalp.L..ouP..FlhSClLV.llNHaLhFpa.Fsp...............................................h.sFsE.lhuaFslClWllPFAlFVSLSAs..-NVLPohspt.s.................................................+t+t.Ghh.slhs.h+t..h..........................................................	0	59	97	141
+2065	PF04149	DUF397		Domain of unknown function (DUF397)	Bateman A	anon	Pfam-B_3066 (release 7.3)	Domain	The function of this family is unknown. It has been suggested that some members of this family are regulators of transcription. In  particular, it is thought that this may regulator of antibiotic production in Streptomyces coelicolor [1].  	19.70	19.70	19.80	20.00	18.90	19.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.82	0.72	-4.39	107	1426	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	87	0	637	1558	2	53.40	37	77.67	CHANGED	pspW+KSShS...........................sssusCVEV.A.......................ssss......s.lu.VRDSK.......c.P.sGPsLsassstWsuFlsus+s	...........................................t.htWpKSSaS...........ssuusCVEl.A.................t.hss.............s.lslRDSK.......s.s...sGP....sLhhssstWsuFlsusp................	0	143	532	615
+2066	PF04187	DUF399		Protein of unknown function, DUF399	Mifsud W	anon	COG3016	Family	No function is known for any member of this family.	27.70	27.70	27.90	27.70	27.40	27.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.51	0.70	-4.84	84	689	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	634	1	222	600	105	207.30	26	61.87	CHANGED	slshpplhtpltsscllllGEhH-ss..scHtlQhpllpsL......tp.....ps.phuluhEMhspcpQshl-pahsu..........phsppplhpthta.p.sWs...ashYpPllphAtppplPllAuNls+shs+plsctG...httlstt.ccthlss.ts..h.s...ssshcphh....tphh.....suH.tt..............................................................hsps...ht.................thhpsQ..thhDpsMApslhphh.........sttllllsGshHs...cpshGlPtpltc	................t.hohpplhtclt.s..AcVlllG..EhH..sps..tcHthQ.htllps...Lt........pp...............ph..phsluhEMhspspQshlD....ph.hps............plspp.pLhpth..h.p..s.....Ws........aptYpPllph.Ahppph..slluuN.ls+phl.pplhp.G....htth.........ppp...h...l.ss.hs......h.s...ssshcphh.t.hh.....tu.Hpts......................................................................................stp....hp.............phhtsQ..hhtDcsMAcsllpth..................tphllllAGshHs...ppshGlshplt........................................................................................................	0	76	146	189
+2069	PF04165	DUF401		Protein of unknown function (DUF401) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Members if this family are predicted to have 10 transmembrane  regions.	24.00	24.00	24.00	24.10	23.70	23.90	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.41	0.70	-5.45	4	109	2012-10-02 15:12:49	2003-04-07 12:59:11	7	2	97	0	54	238	36	372.40	24	97.56	CHANGED	slolLLh.FsVllVLIhl.KVNIGluIFlGuhhLAhLotLGlsGhLhoLh..us..pWsplhlIlIIuFlhGhopha..hGhLc+hppuhhclFs..KaShhhlPALIGLMPMPuGALlSAPMlcslspcaplsPEhtTllNYWFRHlWEh.WPhY.AlVlsSAllGlshtclSlphFPlsllhhhlGalFFstshccshpssRN....Lh..lhslYPIllllllSVlltLDhLhG.hluhLSl.l.NhhRlp.L+ElLcRsFp.+.IlhLLhAVMhaKsVIEsSGls-ulsthhlSaplPshllLhlhPhllGlhTGIohAYVuhshPLLpsFFou....hcplsLsYhuGYhGllhSPVHLClVhSAEYatsEltKlY++hLLPullhhllGhlhlhlI	................................................................h...hhhhh.hl.llhhh....h.h....+.+.ltl..u...h.uhh....hu.u.h..ll..shhh......h....s.h....pthh..h.shh....ss....phthlt.hl..l...h...l...hh.l..hshh.ph....Ghlcphhp..ulptlhsp...+hshs..h..hP..AhIGLLP.PGGAlhSAP.hVcp.ssp.ch.tlssc...cpshlNYWFRHlaEhhhPlYsulllsusls.s..lsltph.lhth.hPhs........lhhhlhG..a.l...hh.hp..........h...h.......pp........t.......t.....pt..ps...................................hh..hl..hs.hhPllssl....h........l.....s............l........h...h.............t...........l....s............h.h.........h...u..h.h...h.s.l...h....s....h..h.lht......hh.php.l.h.phl...ppuhp...h+....ll...hhl....h.hlhhFpphl.p....h...oG..sh....ptlsthhht.hs.lPh....hll..hhhls....FlhGlhTG....h....s.....uhl.ulshPl..lhsh..h..s.u.......hshh..s...lsahhuahGhhl.SPsH.l.CLllos-YFcschhplh+...h..l.h.hs.h.llhhh..hshh.....hhh........................................	0	28	44	48
+2070	PF04167	DUF402		Protein of unknown function (DUF402)	Kerrison ND, Finn RD	anon	COG2306	Family	Family member FomD is a predicted protein from a fosfomycin biosynthesis gene cluster in Streptomyces wedmorensis [1].  Its function is unknown.	21.50	21.50	22.10	21.50	21.30	19.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.26	0.72	-4.15	76	1865	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1388	4	316	897	10	69.90	40	36.02	CHANGED	hcttchhlphh..tsphaslthhh.cs.psphhshYlNlssssthppp....slchlDL.LDlh....l..hsss.....phpllDtDEh	..................................sc....csslsaFa..pc..haasl.....hsMh..cc.......s....slpY..YsNluo...Phhh.-cc............sl+alDa-LDlp.............V..hPsG.......chcLL.DtDEa.......	0	95	196	271
+2071	PF04168	Alpha-E	DUF403;	A predicted alpha-helical domain with a conserved ER motif.	Kerrison ND, Finn RD, Iyer LM, Abhiman S, Burroughs AM, Aravind L	anon	COG2307	Family	An uncharacterized alpha helical domain containing a highly  conserved ER motif and typically found as a tandem duplication.  Contextual analysis suggests that it functions in a distinct peptide  synthesis/modification system comprising of a transglutaminase,  a peptidase of the NTN-hydrolase superfamily, an active and inactive  circularly permuted ATP-grasp domains and a transglutaminase fused  N-terminal to a circularly permuted COOH-NH2 ligase domain [1].	19.00	19.00	19.30	19.30	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.91	0.70	-5.05	180	1295	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	831	0	486	1208	743	297.00	26	60.07	CHANGED	MLSRsA-sLaWhuRYlERAEssARllc.ssh......phshst.....ssss...ppht.slltssGstssattp...........t.thstpslhpalhh..DpssPuS..lhuslpsARpNA+tlRstlos-hWcslNphahplpphttpth..........................sppshh..phhchl.pppsthhpGhhpsoMhRs-uacFhplGphlERADpTuRlL-l+atsh.......................ss.h.-thpWpslL+usuuhpsYRphY.psshpstsls-hLlL-sphPRSltaslpplpppLppLt....tt..st...spspchhsp.lpspLphs.slcclh...................ttuLcpaLsphhpplsplustIsppYh	....................................hhSRsA-sLaWhuRYhERAEsh.ARllcssh.....phthts..........tsss.........ptht....sll....ts.hG..h...sshtpt...............h.......t...hs..tp.s..l...lphlhh......DtssPuSlhuslpsARpNA+slRstlos-hWcslN.s...hh..h..t.....l.pp.h.t.p.p.s.............................................ttt.shh....phhphl.tpps.thhpGhhtsohhRs-uapFhplGphlERu-t...ssRlLssphthh.........................................t..hcthtapslLcsssuhtsY+phY.p.s.t.hp...stsls-hLlLctphPRSlhaslpplpppLpp.L................t.thsstspchhsplt....s....pLphh..shpplh.........................ttsLpphLsph.tphtplustlsppah..................................................................	1	137	300	400
+2074	PF04175	DUF406		Protein of unknown function (DUF406) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterised enzyme specific for gamma proteobacteria.	25.00	25.00	25.60	32.60	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.10	0.72	-3.52	51	1127	2009-11-21 14:42:31	2003-04-07 12:59:11	7	1	756	3	94	348	5	92.60	50	97.42	CHANGED	p.p..pps......-pCssCt..sssDlGslIDssDsshplshshsspttAcsthsphsp+A+ssp.....splpsplsss.-suhpLphsFsFpCpAEphIFQLphR	.............Mp...sss...DcsssC...CshDlGTlhDNsDCTupaSRhFAoRtEAEptLstLs.E+A+uVp..oEsspls.phs-..p.sGVcLDhcFTFuCpAEhlIFpLuLR.....	0	8	27	63
+2075	PF04174	CP_ATPgrasp_1	DUF407;	A circularly permuted ATPgrasp 	Kerrison ND, Finn RD,Iyer LM, Abhiman S, Burroughs AM, Aravind L	anon	COG2308	Family	An ATP-grasp family that is present both as catalytically active  and inactive versions. Contextual analysis suggests that  it functions in a distinct peptide synthesis/modification system  that additionally contains a transglutaminase, an NTN-hydrolase,  the Alpha-E domain, and a transglutaminase fused N-terminal to a  circularly permuted COOH-NH2 ligase. The inactive forms are often  fused N-terminal to the Alpha-E domain [1].	100.00	100.00	101.20	100.50	99.90	99.40	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.93	0.70	-5.82	28	1353	2012-10-10 13:17:03	2003-04-07 12:59:11	8	8	856	1	522	1302	873	327.40	42	53.87	CHANGED	PtlIsusEWstlEpGlhQRscsLsthLsDlYucpcllps....GllPsplVhusssatcthhGlpsPtshalHlhGhDlsRss-GpahVLEDNscsPSGluYsLENRphhpRhhPclapph.....plpslssahptLhcsLpshusss...sPp.lVlLTPGsaNusYF.......EHuaLA+phGl.LVEGcDLhlcDs+Vah+Th.pGhp.pVDVlYRRlDD.DaLDPLthpsDShLGVsGLhpAhRtGsVsls.NAhGoGls-DKulhsal.Pphhchh....LGEc.hLss..VsTahCsps.schcalLspLccLVlKsstssG.....GhuhllGsphop.tptphhpchhtts..salAQ	....................................PRlIsusEWppl-pGltQRlcALNtaLsDlY.s.....c.Q...........cIl+s....GllPscllhusst...a...h....t.....hh..Gl...p.....s...P........s.s..l.......a.....hHlsGhDLlR.s.s....-....G....p....ahVLEDNhRsPSGlS..YhLENRchhtR.haP-L...Fpph.........plps.l.s.s.Y....sptL........h.psL......ps..........h...............uP.................s..................s.....................ts...........Pp..lVlLTPG.haNS.A.YF.......EHuaLAcp.h......G......lpLVEGpDLhV.c.D.s.p.VahR.....Ts.pG..h.c..pVDVlYRRlDD.s..FLDPLsFR.s..DS..hL..GV...s...GLlpAhRuGsVslu.NAhGoGluDDKulYsal..PchlcaY......LG.....E.c....sl....LsN.....VsTahCtcs..sphpaVLspLs....c....LVlKssps..uG.........Ga..Gh..l.lGPp......soptphtpht.t.+.l.hspPt.saIAQ......................................	0	150	328	435
+2076	PF04181	RPAP2_Rtr1	DUF408; 	Rtr1/RPAP2 family	Wood V, Finn RD, Bateman A	anon	Pfam-B_22202 (release 7.3);	Family	This family includes the human RPAP2 (RNAP II associated polypeptide) protein and the yeast Rtr1 protein [1]. It has been suggested that this family of proteins are regulators of core RNA polymerase II function [1].	20.20	20.20	20.70	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.14	0.72	-3.89	45	383	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	326	0	228	335	3	76.20	28	20.32	CHANGED	hsphlo.spYc-llpER...sls.phCGYs.lCspshtph......pppaplssp............spplaphp..c.t..........................................paCSptChpt.StahpsQLsp	..........h...hhp.spYp.-llpER....sl..phCGYs.LCscshpp.....................+tpa+lstt..................ppplhshs..c..t.....................................................................................................................paCSptChcp.upahthQl.......................................................................	0	65	117	185
+2077	PF04188	Mannosyl_trans2	DUF409; 	Mannosyltransferase (PIG-V))	Wood V, Finn RD, Mistry J	anon	Pfam-B_9248 (release 7.3);	Family	This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface.  Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI [1] [2].	22.40	22.40	22.50	22.50	22.00	22.30	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.93	0.70	-5.57	4	631	2012-10-03 03:08:05	2003-04-07 12:59:11	8	10	512	0	342	606	30	277.80	20	72.07	CHANGED	Rpt..lhhatlhsRhlhLhLshLa..hhhshsputshssss......s.sthlsshhp+hLhs.hlpWDulaFlc..hucsG...aEppaAF.sLaPhhlplhs.phhsslhsLLultushh.shh.ls.hlhahlAshhLaplsp.lhpspchohhsullFChoPAulFhouhYSEuLaAhFoFsGlhph.pup........shsushhFuhush.hRSNGlhsssahshsthttha..uLhpLphshhhhphhsuhhLpshhlhlPFhh.QYYu.YppFC.st.........................s.sWCptplPL........lYsaIQchYWs...VGFLKYaphpplPNFLhAsPslIlllauhhhahp.........G.phsphppp.t.......................................................alVhsuhhlhhusFhMHVQVLsRhhS.uhPlhYWahAchlh.s.........Kpp.hpshu..............hthhhhWhs.............hYhlLtslLausFLP.s	........................................................hhh....................................................................................................................h.t.hhpWDs.aahp............lA..p....p.............G....Y..........................h...........t............t...........p........h...........A...F.......hP.hhP...hh.lp.......hh.......s..............................................h..........h......t.........................h.........h...s..h..h..l.s.....hh.........hhu..s...hhLapl...s.t...h......h.......................t.......t.........s......h.....h.............s.....sh.La.hh....sP.u.s.l.Fh.s.ssYoEu..............h......Fshhshhuhhhh..tsp................................................h.h.h.us.l...h....h....u...l..Ash..hR..ssGl...h.h...s...h...hhh.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	123	207	294
+2078	PF04190	DUF410		Protein of unknown function (DUF410) 	Wood V, Finn RD	anon	Pfam-B_12495 (release 7.3);	Family	This family of proteins is from Caenorhabditis elegans and has no known function. The protein has some GO references indicating that the protein has a positive regulation of growth rate and is involved in nematode larval development.	19.50	19.50	20.00	19.80	19.20	19.40	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.73	0.70	-4.84	5	337	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	275	7	236	317	2	239.10	26	79.21	CHANGED	sppK+a--AlELlasGAppFFcccQpuSAADLshhlLEsLEK..........AElssuspplssLAcllstLsPuEPE......RcshVsRslcWS.....osucGKaGcPsLHpllAppLlctcplppA++HFLLusDsSupAphhLlEYpps+spcuEs...DhFlucAVLQaLsLcNhsoAhsoFTpYTc+ahc..tPphEp.....hchsaPacpPLLNFLalLlhsl-sKcpusFpsLsppYpspLKRD.uapuYLs+IGpLYFGI+PspspSs..uLGGLhSuLLu	...........................................................................................................tpppaspAh-llhpGAhhhhpt.s..Q.....t..s....SuuDLu...h.hll.-shpp....................................sph..ps..s..pt.....h.....t.cLhp..lhphh.....s...sppsp............................+ppalppslpWS........................ph.u.p..h..ph.Gc..P..cLHphluphh.......h............c..............-...........p..............p.............h...........h...c........Ac..hHhlhu.........scsps...hs........hl.............ht.p.s...t.s....-s...............shahucAVL.aLhltN...hpsAptshptat..p....p.......t..t..ht..........................t......s...P...L...L....NFl.hLLh.s.lpp.....t....p.......h.........s...h....Fp..LpppYtsp...l...p..c..s.s..app.hLptIGphaFs..h.....sp.p.t..s.....hhshhushh...................................................................................................................	1	77	131	196
+2079	PF04214	DUF411		Protein of unknown function, DUF	Mifsud W	anon	COG3019	Family	The function of the members of this bacterial protein family is unknown. Some members may be involved in conferring cation resistance.	21.40	21.40	21.40	24.40	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.50	0.72	-4.47	109	858	2009-09-11 13:47:38	2003-04-07 12:59:11	8	4	685	0	253	667	461	70.00	47	46.02	CHANGED	pVpspsss..-hssl...KpchGlP.splsSCHTAll..s..GYslEGHVPAssIp+LLp-+.Pp.shGLAVPGMPhGS..PGM	.............t.Vpshpss..shssl...KpchGls.spLtSCHTAll.s...GYllEGHVPAssIc+L.Lpp+.....Pp..shGLAVPGMPhGS..PGM......	0	45	144	209
+2080	PF04217	DUF412		Protein of unknown function, DUF412	Mifsud W	anon	COG3092	Family	This family consists of bacterial uncharacterised proteins.	20.70	20.70	20.90	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.85	0.71	-4.38	21	797	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	793	0	92	296	13	139.50	64	94.36	CHANGED	shh.phlpcGQpYMKoWPhcKpLushFPEpRVl+AT+aAl+hMPslAllolshQhhh...shphhP.pAlshALFhlSLPlQGLaWLG+RupTPLPsoLhsWap-lppKLtptGhshpslpu+PsYp-LAplLKpAFcpLDcsah--	.....saF.olF+RGQHY.KTWPh...EKRLAPVFsENRVIKhTRaAIRFMPPlAVFTLsWQIAL.............GGQLGP...AVATALFALSLPMQGLWWLGKRSlTPLPPulLsWFYE....VRuKLpEuGQs..........L.A..PVEGK.PcYQuLADsLKRAFKQLDKTFLD.D..........................	1	8	29	62
+2081	PF04219	DUF413		Protein of unknown function, DUF	Mifsud W	anon	COG3085	Family	\N	25.00	25.00	32.30	32.10	24.00	22.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.09	0.72	-4.24	23	807	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	791	0	100	247	13	91.50	65	80.88	CHANGED	+FaDspNFPRGFuRSGDFTlpEAplLEpaGpshpuLtsGphpPpsc-EppFltsspGppssso.hE+sWhKYhchspp+p+FaoLsGst+..ss	........RaFDNKHYPRGFSRHGDFTIKEAQLLERHGaAFN-LDLGKREPVTEEEKhFVAVCRGEREPVT-tERVWSKYhTRI+RPKRFHTLSGGKP...Qs-...............	0	12	37	70
+2082	PF04220	YihI	DUF414;	Der GTPase activator (YihI)	Mifsud W	anon	COG3078	Family	YihI activates the GTPase activity of Der, a 50S ribosomal subunit stability factor [1].  The stimulation is specific to Der as YihI does not stimulate the GTPase activity of Era or ObgE. The interaction of YihI with Der requires only the C-terminal 78 amino acids of YihI [1]. A yihI deletion mutant is viable and shows a shorter lag period, but the same post-lag growth rate as a wild-type strain. yihI is expressed during the lag period. Overexpression of yihI inhibits cell growth and biogenesis of the 50S ribosomal subunit [1]. YihI is an unusual, highly hydrophilic protein with an uneven distribution of charged residues, resulting in an N-terminal region with high pI and a C-terminal region with low pI [1].	25.00	25.00	51.50	34.20	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-11.16	0.71	-4.92	30	794	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	788	0	94	348	14	164.80	55	94.86	CHANGED	RKusp.sssp...hssps++psRtpl-spuRpcK+cKK++GhcoGSRpstsptp..pp.psssppKDPRlGSKKPVsLhVpttstsp.........Php.....pps.............+LosEQELtpLENDtpLNpLLDpL-sGcsLussDQpaVDcpLDRI-pLMpcLGIp----s............ptps-DDLLcpFE	.....................tss.......tsK...utuKsR.RKTR-EL-tEAR-RK..R..pKK++GpAsGSRsuuGsss..usucs.Qst.KD..PRIGSKpPIPLs..VsE.psstp+.p.......PKs.......cKP.......................hLSPptEL-hLEsDERLDALL-RLEAGETLSAE-QuWVDsKLDRIDELMpcLGLohDDDE........E--..................E-EKQEDhhRL..h...................	0	10	31	64
+2083	PF04222	DUF416		Protein of unknown function (DUF416)	Mifsud W	anon	COG3068	Family	This is a bacterial protein family of unknown function.  Proteins in this family adopt an alpha helical structure.  Genome context analysis has suggested a high probability of a functional association with histidine kinases, which implicates proteins in this family to play a role in signalling (information from TOPSAN 2Q9R).	22.30	22.30	22.60	22.40	20.20	22.20	hmmbuild  --amino -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.98	0.71	-5.16	48	828	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	821	2	104	339	19	190.50	67	96.99	CHANGED	sshapRLcpLcsWQplsFhsuLCERMaPNYpLFs-hophu-.sphh+slLsLlWEhLssK.su.KlNF-pQLEKL.EphlPsss-.aDhYG...VYPAhDAChALusLLp........uhlstcsh.-cslplSplShsTVAsalE...spsscEls.--p.......lcppthhppEh-lQhplhchL..p-sppR.ch-lIcsL+p-lpps.GlSNIGIsl	.............................NPIHLRLE+LESWQHlTFMACLCERMYPNYAhFCpQTtFGD..upIYRRILDLIWETLTVK.DA.KVNFDSQLEK.h..EEAIPuADD.aDLYG...VYPAIDACVALSELlH........SRLSGETL..EHAl-VSKsSIoTVAMLEM..........TQAG..R.EMoDEE........LK-NPAVEpEWDIQ.WEIFRLL..AE.CEER.DIELIKGLRuDLREA.G.SNIGIt.h................	0	16	40	74
+2084	PF04224	DUF417		Protein of unknown function, DUF417	Mifsud W	anon	COG3059	Family	This family of uncharacterised proteins appears to be restricted to proteobacteria.	22.10	22.10	22.40	24.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.14	0.71	-4.90	6	870	2012-10-02 13:32:46	2003-04-07 12:59:11	7	2	767	0	99	439	11	168.40	46	92.16	CHANGED	h+hhchlshtschslsllRLulhIlFhWlGshKassaEA-uIpPhVuNSPahSahYch.p......................................ssYssS.hLGllEsIlulhlLlGhhpstsGllGGllshshslVTLSFLhTTP-sahst............P.LuGssphVlKDlLhlAuulhlhthstpchL	....................................hclluptsclGlsLlRl.uIsIVFhWIGhLKFssYEA-uIsPFVANSPhMSFhYca.t...p.h.pc..puE............................c.thtWpptNsTYuhSsuLGllElIlulLlLss...h..s.h..lGLlGGlhAhshslVTLSFLITTPE..sWVssLGss.............paGFPaL.S.G.A.GRLVLKDhlhLAGAlhlhu-uA+cl...............	0	23	57	78
+2085	PF04235	DUF418		Protein of unknown function (DUF418)	Kerrison ND, Finn RD	anon	COG2311	Family	Probable integral membrane protein.	20.80	20.80	21.00	21.00	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.94	0.71	-4.57	138	1711	2012-10-02 17:00:17	2003-04-07 12:59:11	7	6	1135	0	378	1373	248	158.90	28	41.74	CHANGED	hs+pshhp.tsppptphhpphhhhs..lslulshtlhhs.....................hhtshhhhhhthhuuhh.huhsYluhlhhlhpptth.ht.....h....hpslsssGRMALTNYlhQSllsshlF.huaGLGLhsplshh....thhhlslslahlQlhhSphWL+pF+hGPlEal....WRplTatp	........................................................................hh+pshhp..sp.p..hp...hh+..+hth..lh...lsluls.lsh.th..................h.h...s.ht.hss.hh.h....ph.......h.....p...luus...h.......huluY.suhh..hhhh.phpt..hp..............l.....ltsls.slGRMALTNYlhQ.........ollss..hl.F...................a.t.hu..L...hh...p.......h....s....hh....th.lhhslsl....ah.h.pllaSslWL.+.h.a.+.pGPlEWL....WRplThh.t......................................	2	131	275	337
+2086	PF04237	YjbR	DUF419;	YjbR	Anantharaman V, Kerrison ND, Finn RD	anon	COG2315	Family	YjbR has a CyaY-like fold [1]	25.20	25.20	25.40	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.31	0.72	-3.64	196	3031	2012-10-09 12:12:44	2003-04-07 12:59:11	8	8	2138	7	527	1873	137	96.50	28	68.23	CHANGED	shuhPsspcs..hsa........st....hsa+V...............u......KhFAh....hsttt............................lslK..sssppt.thLhpp..sshhsu..+hs+..pp.Wlsl.h...l......t.slspsplpchlccSapLl	...................................................shth..tsp.s...h.a.......s...ph...ssh+l..........ss..KhFAhltphptp.........................................hlsLK..s..s..P..-..hs..thLppp......ss.l.h.P.u.a..Hh.NK......pH.WloVh..........l........sssls.c.splhcLlscSaplh..........................	0	174	335	445
+2087	PF04238	DUF420		Protein of unknown function (DUF420)	Kerrison ND, Finn RD	anon	COG2322	Family	Predicted membrane protein with four transmembrane helices.	28.50	28.50	28.60	29.00	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.73	0.71	-4.21	60	636	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	597	0	165	381	289	133.90	42	79.22	CHANGED	lshLPhlsAslNuloslhLlhGhhhI..+ptphphH+phMlsAhshoslFLlhYlshphh.sssos......FG..............Gtu.........hl+s.lYahlLIoHIlLuslslPLsLholhhuhpp.................phspH+KluRhThPlWlYVulTGVlVYlMlh	.........l.sILPplsssh.sloslhlshGhhhI...........h.++plptH+shML..uAhshuLhFhlhYh..o.hp....hh......hssT.s.........FG...............Gsu..........I+h.hYh.hhLhh.HIhLAslsssLuLhsllhuaps..................phshHRKlu.ashsIWhhsulTGVh.VYLhl................	0	65	126	155
+2088	PF04239	DUF421		Protein of unknown function (DUF421)	Kerrison ND, Finn RD	anon	COG2323	Family	YDFR family	27.40	27.40	28.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.02	0.72	-4.48	196	3034	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	1816	4	627	2119	40	94.30	26	48.77	CHANGED	ccllpGcPhlllcsGclhpcsl..++p+lohs-LhttLR.pp.ul.hsls-VchAlLEssGplSVlh+s.p..tsht.....................................t.t.h.t.h.....................hpcl	..............chlcGcPsllIcsGclhhcpl..pptphots..-lhhpLR.pp..G.l...h.......pl....ppVchA.lLEsNGploVhhtt.c......h...............................................................................hhh....................................................	0	243	460	537
+2089	PF04240	DUF422		Protein of unknown function (DUF422)	Kerrison ND, Finn RD	anon	COG2324	Family	Predicted to be an integral membrane protein.	25.00	25.00	27.00	27.00	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.57	0.70	-4.93	13	245	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	225	0	128	250	252	208.50	23	75.40	CHANGED	uFs.hhsLhGlhsMthshlAuhl...phl.stRuhuhllshsuhuhulELLGspTGaPaGcatYsssLGPhluGhVPhslPluaFsLslsuYLLs..hshLu.csppphl+hhts....uhhlsshDlVLDPuhs..ulsFWsW.ssGsFa.GsPhQNaAGWlLoGs.luhslhsluashsulptchp....ssshhLsshVuhhhhhsslsLhhGhhlPstlulhLGluhl	...............................................................h..........hhhhhhhhhsshh....hph.G..h..tp...s.h.hh.hs..hsh....s.luhs...sEhlGl..p.TG..a........PFG.pYpY.s...s...s.L...G....pl.h.G.VPlhlsluW...hhlshsuahlu.............thhl....t............................t...t......t....h.h.p.hhhs...................uhhhsshDlhlDP.shs......sh.s.aW......h......W....p..s..............s.............G........s............aa....G...lPlpNahGWhlsuh....lh..h.hl..h.p.h..h....ht.h...t....t..h..................h..h................hh....hh.h............................................hh................................................................	0	43	103	124
+2090	PF04242	DUF424		Protein of unknown function (DUF424)	Kerrison ND, Finn RD	anon	COG2412	Family	This is a family of uncharacterised proteins.	25.00	25.00	27.10	34.40	24.90	18.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.59	0.72	-3.94	44	146	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	142	4	72	141	21	91.50	26	84.16	CHANGED	apsss..hhluhs-cchhGppapctp..hhlplscuFassphs...t.ppslptLpcs.........slsNlhGpcslshult.Ghhc.ssVhhlsuss+splspl	.......pspsp.hlluhCDc-llGcpaccsp..lhlplsct..FYsschs...p.-pshptLpcA.........slsNllGpcsVthAlchGhlc.ssVlhlsuss+AQlhph...	0	19	46	61
+2091	PF04248	DUF427		Domain of unknown function (DUF427)	Kerrison ND, Finn RD	anon	COG2343	Family	\N	20.70	20.70	22.80	20.70	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.09	0.72	-4.32	99	1160	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	605	5	492	1041	207	92.70	32	63.77	CHANGED	lpVhhsGtllA-opcslhlhE...sshsPsaYlP.pDlph.s....hLp..o.sppohCPaKGpAs.Yas.l.....ssts..tpsAAWsYsp.Phss.sstIpsalAF.as.stl	...............................hplhhsGtllA-..o..p..p...s.lhlhE...sshss.....h.......aY.lP.sD.lp.h.p..........h.Lp.t.o..sp.p..ohCPaKGpAs.Yas.l..hs...sspt..................hpsAAWsY.p.P.hst.....s.....tt.....I....tsalAFass...........................................	0	132	295	403
+2092	PF04250	DUF429		Protein of unknown function (DUF429)	Kerrison ND	anon	COG2410	Family	\N	20.20	20.20	20.30	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.54	0.70	-5.07	41	405	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	389	0	180	381	182	209.30	20	83.95	CHANGED	GlDhs....+suhlAlh..........ptsphhphthh..s.scllshhtst.....tllulDhPluL...............tss............tshRssDpthR+h..ht.....plF..Psp.shhtp.................................lotpuhplh..............tphthclhEsHPpsshptl.....ssstt.........t...tsh..RhthLtt.h....................th..shtpcDllDAhssAloAth.h.hpGps......hplsst.st...hspts	.......................................................GlDhu.....p.shlush..............tssph.h...thth...ht...s......tpllshhpsh...........shlulDuPlsl............st.................................................sutRss-pthpch......ht.........t.ssa.....sspt..shhsp..........................................................h.s.puhp.lt.........h.t....h...t........h...........t..ptstplh..EsaPc.su.h.h.sl.............ttt.t...............ctp....tps.h...t...t....hh....p...hLhphh................................h.....t..th.tp......htts-D....h.lDAhlsAh.sAhh...h.....s.h........h..............t................................................................................................	0	61	121	150
+2093	PF01861	DUF43		Protein of unknown function DUF43	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes archaebacterial proteins of unknown function.  All the members are 350-400 amino acids long.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.51	0.70	-5.39	6	163	2012-10-10 17:06:42	2003-04-07 12:59:11	11	3	152	1	80	301	87	239.00	33	61.06	CHANGED	-lLc+FpEIAK-RPcslppYDQGaVTPEoTluRVtLhasRGDLcGK-llVlG.DDDLTulAhuLTshPK+lsVlDIDERLIcFIc+sAcchGls.lEshsaDLRpPLPEchh++FDsFlTDPPETlhul+sFlGRGIusLKGtGsAGYFGlT++EuSlcKWtEIQRhLl.-hGsVITDlIcsFNhY.NWsYhppTRAhphlPlK+......cPEc.WYpSshaRIEsLc....s..+th-EElscsEclYpD-Euos	.........................................hhcchpplscsRP..pshtphD.QuhsTsETsltR.sh..l..h..tp+G.DLpGKcll.sl..G..DD.DLsS.......lA.l..u.......L...........o..........s.......h........s.....p........c....lsV..lDID.-RllcaI.pchAc...c...hsl.....s...lcsh..pa...DlRp.sLP.c...chh..sp..FDsFh...TDPP..........Tl....p...Gl.cLF..lu..R.G.l..p.sL.+.s.p...G...s......s.u...Yh....u.hoc.cc..s...o.hpcah..plQ.+hLl.chGl...llp-Il.sFNpY....shs...h...l.tp......hh.......h..h.p...................p..ahh....hhphh........................................................................................................................................	0	26	46	66
+2094	PF04254	DUF432		Protein of unknown function (DUF432)	Kerrison ND, Finn RD	anon	COG2430	Family	Archaeal protein of unknown function.	20.70	20.70	20.80	20.70	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.52	0.71	-4.20	17	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	63	0	53	71	5	120.30	27	51.26	CHANGED	hPlstst.thsphlhl+hcpPlllsPtsshphalchPl-luVhhsst..t..thlDhhshs..+tKYsLYGsspsGllsRYhcoplhsc.Pps......pulh+lhlpNpssphspls+lVFshhshphYY	...........Ph.h.t..hsphlhlchpcPlhlsPtsphphalphPl-luVhl.sst..................hlDhh..sls..+.KYsLYGs.s.....s.....sGsls..RYac..Sphhs.....p.Pcs....h...pulhcltlpNssschhpls+llhshhshplYY.....	0	19	33	41
+2095	PF04256	DUF434		Protein of unknown function (DUF434)	Kerrison ND	anon	COG2454	Family	\N	20.40	20.40	22.00	21.10	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.72	0.72	-4.59	19	102	2009-09-10 18:22:19	2003-04-07 12:59:11	7	1	102	0	64	100	2	57.20	35	25.61	CHANGED	tpLpcAhcDlpaLLNRGYs+csuLchVus+YpLstcpRhhLtRslho-c....cltt.h+pKh	.....hLpcAhpDlpaLLsRGYsc+suLphVuN+YpLspcpRhhLhRslhScp....plpt.h+pK........	0	27	40	53
+2096	PF04258	Peptidase_A22B	DUF435; 	Signal peptide peptidase	Bateman A, Studholme DJ	anon	Bateman A	Family	The members of this family are membrane proteins. In some proteins this region is found associated with Pfam:PF02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with Pfam:PF01080.	20.60	20.60	20.90	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.10	0.70	-4.97	14	885	2012-10-02 13:41:03	2003-04-07 12:59:11	8	15	291	2	585	836	37	274.40	29	63.39	CHANGED	pspppstshssptAhhaslsuoshLlhLahhachht..............................................................llhshFslsush.....................hahlhsshhph.p...............phsttphph.....................hphphshtplhshhhslslslh.alh+p..+..WlhpsllGluhslsslphl+LsshKsuslLLssLFhYDIFWVF........uosVMVsVApu.h-s........................PhhLhhPph............ssssaShLGlGDIllPGlhlAhshRaDh.t..................ptppps.YFhsohluYslGLllThluhplhc.pAQPALLYLVPssLhshlllAhh+s-L+phWs	.......................................................................................................................................................................................................................................................................t......phs..pA.hh.hslhuushLhh.L.ahh.hp.h............................................................................................................................................................................l.lhh.ha.hlhuhh................................u.hh.h..s.hh..........................................................................................t...tph.h...........................................h.php..h..sh..hpll..shhh.sh.hh..sl...h.....h....l...hpp...p.........W.l.hpshl....Gluhs..l..sh.........l....p.h..l+.L.......s.sh+s....us.lLLss..LFl.Y.D...l..Fa.VF.............sssV.MVpVApu..hcs...........................P..h..hL..h.hPp..............................sstsa.uh....LGlGDIl..l..P..GlhluhshR.a.Dh.h.................................................................................................tt.p.tps..YF..hssh.............lu..YhlGLlhThhs...h..t..lh...p.tu.Q...PALLYLVPssL.hs.hhhAhh...+s-lpthat..................................................................	0	194	304	452
+2097	PF04260	DUF436		Protein of unknown function (DUF436) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of bacterial proteins with undetermined function. 	25.00	25.00	30.10	30.00	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.83	0.71	-4.77	34	978	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	969	3	107	502	4	171.00	54	92.89	CHANGED	pphpphlpEllctusLcpGplhVlGCSTSEVhGt+IGpsuSh-lupslhpslhphhpcpGlaLAsQuCEHLNRALVVERpsAcphshEhVoVlPsh.+AGGuhustAacphp-PV.VEpI..pAcAGlDIGDThIGMHlKhVtVPlRsuh+pIGpAHVTshpoRPKLIGGsRAhY	....c.phppllc-lh-..pusLppG..slFVlGsSoSEVlGt+IGpsuShEluEhIhpslhplhc......ppGIpLAhQGCEHlNRALVVERplAp.p.hsh..E..lVoVlPsl.HAGGShtstAFctMpDPV.VEaI..pApA..GlDIGDThIGMHlKHVpVPlRssl+plGpAHVThhsSRPKLIGGsRAcY......	0	37	64	88
+2098	PF04266	ASCH	DUF437; 	ASCH domain	Kerrison ND, Finn RD	anon	COG2411	Domain	The ASCH domain adopts a beta-barrel fold similar to the Pfam:PF01472 domain [1].  It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.51	0.72	-3.65	85	2885	2012-10-02 17:37:24	2003-04-07 12:59:11	9	30	1955	15	561	1820	99	108.40	21	70.36	CHANGED	hp.........htsp.............htshllpGpKssp......hRhtspsh.....h.uphhll..hp................................spsphhshlclpsV...phh....papcl........spptuh.....-s..............sh..hhp.h.ph.....att............phhlss.p..Fchlt	.....................................thhpc.............htshll.sG.pKThT.............h.+..ps..-s..h.p.......h..Gph.hl.l..hp...........................................................................tp.sp.hs...hlclp.slphh.....phspl............stp...hAh.....tEs....................oLt...hp.ph.htch........a.t.................p..hhh.cat................................................................................................................	0	151	287	429
+2099	PF04282	DUF438		Family of unknown function (DUF438)	Kerrison ND	anon	COG2461	Family	\N	25.00	25.00	25.10	36.30	23.60	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.47	0.72	-4.18	27	563	2009-09-11 06:07:37	2003-04-07 12:59:11	8	11	557	0	100	390	1	72.00	48	16.66	CHANGED	hLKcllhcLHpGtss--lKccFppllsslsstEIshhEQpLlp.-G.lsscElp+LCDlHAslF+sulpphtp	.........lL+-ILhcLHsG..u.osEoVp-cFstpFsGVSAlEIShhE+ELMs...sG.lshEDVhcLCDVHAsLFKsAIcslc.s.......................	0	38	61	76
+2100	PF04283	CheF-arch	DUF439;	Chemotaxis signal transduction system protein F from archaea	Kerrison ND	anon	COG2469	Family	This is a family of proteins that are archaea-specific components of the bacterial-like chemotaxis signal transduction system of archaea. In H. salinarum, the CheF proteins interact with the chemotaxis proteins CheY, CheD and CheC2 as well as the flagella-accessory proteins FlaCE and FlaD, and are essential for any tactic response. CheF probably functions at the interface between the bacterial-like chemotaxis signal transduction system and the archaeal flagellar apparatus.	25.00	25.00	56.20	55.60	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.18	0.70	-5.14	14	80	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	50	0	56	83	0	221.30	22	74.64	CHANGED	ptltph.uphh.hspsshc..pspWpcucllLopcRlVlus.tptph....slslsplpDlssp.s.t........hsthpshsulphppc.....shllsssss.......t.ppFtphlFpsllstptVhlpcsAhhGGsV.p-upWE+Gplplsccslphshsstp..pIsl..............sslusl-tcp+plsGcp+.VLplcHscc.spslsoalh.ssp+p.hplLcthlp.pht..........-......phptth-	.................hlsch.Gphh..hsptshp..tscWpss+llLopcRlllss.pst+t....slslsplpDlsschs.pt......hhs.hsshsslphtps.....shllsstss........hppFtphlapslLs..tptlhlpaPAlhGGsV.p-spWEcGplplscpslph......shsssphhslsl..............sslssl-hpc+pl....sG.cc+sVLclc..Hhcs..sp..oV....soalt.sspcp.lplLpphlc.phh................c.............t...............................	0	7	33	47
+2101	PF04269	DUF440		Protein of unknown function, DUF440	Mifsud W	anon	COG3099	Family	This family consists of uncharacterised bacterial proteins.	21.50	21.50	23.30	58.30	20.80	17.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.30	0.72	-4.00	9	735	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	728	1	72	234	7	105.90	69	97.44	CHANGED	M...p.ho.D-sl-hAYDIFLEhAs-NL-PsDIhLFsLQFE-RGusEhs-suDcWpccVGhpl-s-taAEVhlGLss.Ep-Eh-DlFARhLlSRch-c+hsHllWKc	.MDLN.NRLTEDETLEQAYDIFLELAuDNLDPADllLFNLQFEERGGAELFDPAEDWQEHVDFDLN..PDFFAEVVIGLAD..oEcsEINDVFARlLLCREKDHKLCHIlW+E......	0	4	20	46
+2102	PF04284	DUF441		Protein of unknown function (DUF441)	Kerrison ND	anon	COG2707	Family	Predicted to be an integral membrane protein.	22.20	22.20	26.70	26.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.79	0.71	-4.30	35	1132	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1100	0	140	468	0	136.80	52	91.76	CHANGED	LhLllLlllGllu+NpSlsIAssVLLll+hhs.lsph.hPhlpp+GlshGlhllTlulLsPIAoGcIshcsLhpuhhShtuhlAlssGllVAhLuucGVsLlssp..PplssuLllGTIlGVuhhpGlsVGPLIAAGIshlll	...............LlLLsLhhLGhlu+NsolslulhVLlll+lTP.Ls..........sa............FPalE+pGlslGIlILTIGVhsPIASGpls.ssLlcSFhs..aKullAIulGlhVuWLuG+GVsLMusQ..PpllsGLLlGTlLGVAL..F+GVPVGPLIAAGlluLll......................	0	41	78	108
+2103	PF04273	DUF442		Putative phosphatase (DUF442)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	Although this domain is uncharacterised it seems likely that it performs a phosphatase function.	24.60	24.60	24.60	24.90	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.29	0.72	-4.20	5	718	2012-10-02 20:12:17	2003-04-07 12:59:11	8	8	547	8	211	636	313	108.40	33	46.58	CHANGED	-hRclo-cLSVSPQlss-DlAshAcpGF+olINNRPDGEEPuQPuNAAlpAAAcAAGLuYsalPVhsGsITs-sVcuFpcAlAsA-GPVLAaCRSGTRulsLYALuQAlc	.....................................hplscphslu.s.Ql.sssDl.t.p.l.u.p.tGa+olIsN.R.PDsE.t.s.s.QP.s.h.tp.l.pps.AcptGl.s.a.h.alP.V.s..u..s.p.l.o.p.p.sV.......ppF.t...ph.ls..p...h..t..t...P.VLA.aCRoGs.Ru...ss...Lasltp...t.......................	0	62	127	168
+2104	PF04276	DUF443		Protein of unknown function (DUF443) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of uncharacterised proteins.	26.20	26.20	26.40	26.40	26.10	25.80	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.36	0.71	-4.88	22	1105	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	227	0	32	406	0	179.30	47	93.80	CHANGED	Ns+YRIlchssEYhhlDl.ssoahshhFPhlsWllP+chhKIopcEh.EpLphs+ss.........Kspsh.hsshGu...ulLlushlRthhphhslphpphlshhlshlshlhllhhalhls++h+hplas.s....ppscpKlhlhP.ohKphhhhlFsYlhhhuholhslhhhl..pspNlIhalshhhhh.hhhhhlNhhoIss.ppspVhh+	.............................................NPKYRlI+YssEYLMlDl..lS.oWlshFhPhINWhIPK+YsKIS..ccEa..EsL...Nl...VKPs.........KspsF.....WPlsGu......ol.LhulhhR....K..Yhhlh...slpL.-Kp.lVIhlChlshlG...ll..hFalhLN+K.LpLplas.s....+spppKl..l..LlP..ohKsh..shh.lFsY.l..hhGuhShhhl.hLlohs.QNIIlalsW.lhhh.hhF.FhlNhssIhs.Kpl+Vlh.................................	0	13	24	31
+2105	PF04285	DUF444		Protein of unknown function (DUF444)	Kerrison ND	anon	COG2718	Family	Bacterial protein of unknown function.  One family member (Swiss:Q97LI1) is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA).	20.30	20.30	20.40	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.35	0.70	-5.84	8	1564	2012-10-10 16:07:06	2003-04-07 12:59:11	7	3	1281	0	389	1028	179	338.70	43	98.30	CHANGED	MuhFlDRclNs..+cKohssRQRah++h+.EpIKculsDtVsc.cSIsshsutEslpIPtRulcEsph+.Gc.sGcpc+VtsGsc.....c.psGDhIsRssuGsG.tGsGcGpuuuDsEG.......EDtFphplSp-Ehh-lLFEDLpLPNLp++phsplsp.h+sc+AG.hpssGlsuNIshsRTlpsuluRctuhs+upp..hcu..tpl...t...s.tlhct.......tht.hcs+hcRlP.lcs.DLRa+paccpPcPpSpAVhhClMDVSGSMspscK-lA+RFFhlLphFLpp+YEsVElVFIpHHTpA+EVsEc-FFappEoGGTIlSSAL+hhpElIcERYssAcWNIYuhpASDGDNas-DosRClclLppclhthsphauYsEIs....hpsHps.........hhcYcthpsshDs.FthppI+stsDlaPVh+plFp+Eps	................................................................................t.hIDRR.Ns..+sKShsNRQRFl+Rh+.tpIKpuls-tlsc.cSl....hsh....p....s....s..-p.lsIPh..cslsEP...h...F...+p...Gp.sGhp.c.pV.tP..GNs................cahpsDpltR..PtuGu...............u....GsGpGpu.u.t-.GEG.......pD...pF.FplSp-Eah-hhFEDLtLPNLpppp..pp.lsp.h+.s.cRuG.hpssGs..Pu..NIslhRolpsuluRRhAhsts..t.hpth..........tt.l......h.......t....................t.....t................h..t..l..t..l.ct+htp...lP.aIDshDLRa+sapcpPp.Ps.SpAVMFClMDVSGSMsptpK-hAKRFahLLYlFLpR..pYc.s.V-lVaIRHH.TpA.KEV.s...E.c-.FFau.....pEoGGTlVSSAL+LhpEllc...........pR.YssspW.NIYuAQASDGDNW.s.s.Dosh.CtclLtpcllshspaauYlEls.........ptHps...........WhpYpplp.t.t.h.ss..FuhpplcptpDIaPlFR-LFp+p..u..........................................	0	133	240	315
+2106	PF04286	DUF445		Protein of unknown function (DUF445)	Kerrison ND	anon	COG2733	Family	Predicted to be a membrane protein.	33.80	33.80	33.90	33.80	33.60	33.70	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.28	0.70	-4.93	106	2067	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1694	0	414	1545	89	326.60	24	87.11	CHANGED	sEAAhVGulADWFAVsALFR+P.....lG.l.IP.....HTulIP+p+-clucsLuphVtsphLsscs...ltp+lpphshsptlspaLt..........ps.....spsptl........................sptss.phltthlctlpcpclpphlcptht...............................................pplpph.hushhuplLp.hht-scpptlhDhll......pphtphlpsscsp..ltphlpchhpph.sthh.....................stplsptlhpth.phlcclpt-sp+.hRpphsptltphlscLtps.th..pch-plKpphlsc.thpphhps...lhpplcphlhpthps.s........hlcpplsphhtthsp.........................................pLtp-..splpppls........................chlpptsttllsp.ttplspllp-slcpa-scclpctIEhtlG+DLQaIRlNGollGGllGlll.aslshll	....................................................h.uuhlGulssWhAlphLF..R...P..........h.h....h.lP........p.s..........ulIP+p+-clucsluphVpcchLssps...lhtt....l........cpt..p....sthltphhp............................p...ptsppl.................................................................stphh.phhpt..h..lph.h...t..s...t..p.....lpp.hlpp..t.hp......................................................................................................................................ptlpp..h.hs.t.h.shh.......ppphp..hh-h...lh..............tphh.t.h.ltp.pp.sp..ltp.l.ph.h.pp..sh......................................tthsphh.pt.......phhs.cl.....pt..c........t..+..h.c.....p.t.hs.p.h.h....hl.pp.Lh.p..............tchc.thKphhh.p.c.....t..h.tphhtp....................lhtp.l..pphl.h.s.thsp.p.................hhpp..ltp.hht.h.hp...........................................................................................................................plhtc......stlttplp....................................................................thlpptstplh.p.........h...l..sphlp-pl..psa.Dscchpc.Ip..hs+-LphIch.GsllGuhIGlh.hhls.h..................................................................................................................................................................................................................................................................................................................................................	0	158	296	367
+2107	PF04287	DUF446		tRNA pseudouridine synthase C	Mifsud W	anon	COG3098	Family	This family is suggested to be the catalytic domain of tRNA pseudouridine synthase C by association. The structure has been solved for one member, as PDB:2HGK, which by inference is designated in this way.	25.00	25.00	25.80	25.70	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.97	0.72	-10.29	0.72	-4.20	56	892	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	888	1	128	441	33	100.00	49	91.89	CHANGED	cp.p.ltptLtpLEttL+phsLWpspsPsscAhsSspPFulDThshppWLQalFlPRMptLl-sstPL.PpphulsPhhEcshp..pp...sphptLlshLpplDpLl	..........c.spV+.pLpsLEshLRcpphW..ps...st..Ppsct....FsSspPF.hhDTMcPhEWLQWVhIPRM+sLL-sspPL.PsuFAlAPYaEh..ALs....-+...Pppth..l..L..A.LpcLDsLh......................	0	20	49	93
+2108	PF04289	DUF447		Protein of unknown function (DUF447)	Kerrison ND, Finn RD	anon	COG2457	Family	Archaeal protein of unknown function.	24.80	24.80	25.20	24.80	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.99	0.71	-4.71	45	190	2012-10-02 11:35:36	2003-04-07 12:59:11	7	1	185	12	120	206	54	176.30	24	88.66	CHANGED	hEsllTTtssp....NhAPlGllh...cucs....hhl+lFcsS+ThcNltpsshhslslssDshlaspsshsth..p.tht.sh......h....hLcsuhsahthclpph..........pssspthhhphpslctthtp.....sh...NRupsullEusVhsTRl...ph.....hptcclhpclphhttllcKsGGspE..pcAhchlpc	............................................EsllTThs.p.....phAPlGlhh...................pssp.........lhlphacsopThcNltp..pshsslshs.sDshlFstushs....tthp..h......th...........hLpsuhuahph...clpph..........psssp.h.hhphcslctthpp.....htsa...NRApsAVlEusVhsoRLph........hst-clhpcltahtts.lcKsuGtpE..pc.Ahphl..t.............................................	0	30	74	101
+2109	PF04296	DUF448		Protein of unknown function (DUF448)	Kerrison ND	anon	COG2740	Family	\N	21.60	21.60	21.60	22.70	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.83	0.72	-4.35	155	2403	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	2395	1	477	1345	326	77.80	31	69.80	CHANGED	.RpClsspc.hts+ppLlRlVhss-....u....p.lshD...pt+hsGRGAYl.ssstp..slcpAh.....++..+thsRuh+..ss.............ls..ss..lhct...lpphl	.............RpClsspc.h......tsK..+-LlRlV..t..s.p-...G.......................p..lhhD...soGKtsGRGAYl.shc.....p.slppAt.......++.......+shs+uhchp............lscp....hhcpL.t..h..............................	0	172	342	420
+2110	PF01863	DUF45		Protein of unknown function DUF45	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This protein has no known function.  Members are found in some archaebacteria, as well as Helicobacter pylori.  The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved histidines.  This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.57	0.71	-4.53	82	3481	2012-10-03 04:41:15	2003-04-07 12:59:11	12	7	2755	0	820	2754	698	165.60	22	80.80	CHANGED	+plplplps.ssl.plssPhthsppplpphlpc.....+tsWltpphtchpp............tthhsspth.h..hGcpapLphhtsp.....................hhh.thp.pthpptlpcah+cpspt.hlppt....ltthspthsl...ph.tphpl+sh+oR.WGSC..ss...psplplshcLlhhP.pll-YVllHELsHLh.chNHutcFWpllsphhPs.acct+phLcpt	..................................................................................................................................................................................................................................................................................................................................................t.h......th.h..t.h.t......h..h......h.....h...............h....t...h...................ht.....l.p...p...pp.p..WGoC....pu......c....s.....pIpl...s..h.t.l..h..t....s.P...hl-Y.....ll...lHELsHLt...c..h....s.........HsctFaplspphh.P.p..a+p.hct.Lp......................................	1	265	553	699
+2111	PF04313	HSDR_N	DUF450; 	Type I restriction enzyme R protein N terminus (HSDR_N)	Kerrison ND, Finn RD, Yeats C	anon	COG2810	Family	This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA [1]. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA [2].	21.10	20.50	21.10	20.50	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.44	0.71	-4.56	77	3819	2012-10-11 20:44:43	2003-04-07 12:59:11	9	43	2584	8	831	3899	642	175.90	19	18.43	CHANGED	thsEpthcp...hl..hl...hGaph.................ht................................................................................................................................................................................+sDlslhlN.......................GlPlsllEhKp..................................t.pt......hppLapYs...........................................thhlhoNGpphthhsthsptpp	.......................................................................................................................................E..h.t...h...h.....t......s.at................................................tt....h..t....h.h..t.h.t.p................................................tt.......................t......t..h..h....t....h..h.......t.....h.......................t.......h...h.............hs.h...p..p......t..p................................................................................................Np....h....p..l..spphphp................................sp.ppp+.hDlll.h.l..N.......................G.l.Pls...hlElKp..................s...sl.ppAh.p.......Q..hp.p.Yp.pp...................hppl.a.pah....................................................tlhhh.os.shp.shhhst.t....p..............................................................	2	293	576	721
+2113	PF04301	DUF452		Protein of unknown function (DUF452)	Kerrison ND	anon	COG2830	Family	\N	19.50	19.50	23.70	23.10	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.33	0.70	-5.04	2	358	2012-10-03 11:45:05	2003-04-07 12:59:11	8	2	355	0	43	228	1	204.30	37	95.06	CHANGED	McTpahspQGspLIlYFAGWGTPPssVpHLILPENaDLhlCYDYpDLphDhDFSAYpHIRlVAWSMGVWsAERshQGh.LhSATAlNGTGLPCDDpaGIPpslFtGTLpsLsEssRhKFERRhCGsKs.hcDYQpashRP.htEIHtELhALashltQDRRTDLIpWopAlVGStDKIF.stNQ+tYWpsRCslpEIsstHhLFs+FTHWpsh	.................................p.p.p..u..p.c.LIlhFuGWuoss.shhs...HL..h.......s.....p......s.....+..-l.l.l.s.YDYcsLs.h.......c....F....D........h..s.....u...a...p..c.IpLlAaSMGV.....as.A....sR..l.L..........p..p....l.....p.......h...p..p..t..h....A.....INGTshP.hD.cphGIssuIFctTLcs.hstp...sht+Fc+pht.t-.+p..h.pca.p.ph.s.t.+s.hc-l+pELptL...a.t.h...ht.p..c.....p..p...p..s......h.l.h..W..spsh........luppDcIFPsss..+pha.p..p...h...h......l.....l..-.t.sHahF.+FppWp............................	0	13	26	37
+2114	PF04303	PrpF	DUF453;	PrpF protein	Kerrison ND, Bateman A	anon	COG2828	Family	PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerise trans-aconitate to cis-aconitate [1].	20.20	20.20	20.80	20.80	19.30	20.10	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.34	0.70	-5.72	6	1338	2012-10-03 03:02:41	2003-04-07 12:59:11	8	10	1077	9	378	1097	393	341.90	45	96.08	CHANGED	.l+IPsThMRGGTSKGVFF+hp-LPtss....stRDtlLLcVhGSPDPh..QIDGhGGGsSsTSKVsIlutSSpPstDVDYLFGQVuI-cthVDaoGNCGNlSAAVGPFAIcAGLV.sA+hP...lstVRIapsNhuKhIlAcVPlssGpVp.sG-hplDGVshsuA.ltLsFhDsAssss..GtlFPTGN.lDsL-sst.G.lpsThIssuhPhlhV-A-ulGhsGTELtEElNuD.phLA+hEpLRshuAh+MGhluclc-ts.p.tTPKlAhVusPppYhsSuGthhtus-IDlhVRhhSMt+hH+AhhsTuAVAIuoAsAl.GTlsshhAGust.hssVphuHPSGsLcVtscscp.pt..sh.pAthsRoARhLMEGaVhlP	..................................h+IPsshMRGGTS+GsFhhhpD...L...Pp.st....stRDtlLhtlh...GS..P.......D..sh......QIDGhGGuss.TSKssIlS............+.....................S.s...............c........s..c.....tDV.............DYLFuQVslc.c.sh.VDhosNCGN.h.uu..VGsFAIcsGLl...sup.P....................lspV....RIhpsNh.GphI.AcV..h.........s.....s...G....t..........V....p.......p.....G-.h...clDGVsh.s.AA.VtLpF.lss...Ausps.......Gp......hFPTGN...hl.D.l.......-......s......................................l..psThIssuhPslhlsAps..L......G..h......o.........G.h........E...L.........s...p.ls..uD.tt.hLu....+....hEsIR..htuuhtM......G.lsc......l......s.p.h.s.........hPKhshlus..s...p.....p.uG.........sls..VRh...h....tphH+AhhhTu..AlAIuo.........A....ssl..GT.ls.p.......h...................s.................s.........u.......s...............s.........h..............s....s..................lphtHPSG..sLcVt..hp...s..c...t..tsu........ssh+A..sh.RoARhlhcG.VhlP...........................................	0	82	190	304
+2115	PF04304	DUF454		Protein of unknown function (DUF454)	Kerrison ND	anon	COG2832	Family	Predicted membrane protein.	21.60	21.60	21.80	21.80	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.41	0.72	-3.95	112	2157	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	2047	0	323	1155	310	69.50	27	54.83	CHANGED	hapWLlsH.haGshlcsWpppculsh+uKhhAlhhhhhshshu.hhhssh.hasphhlhshhh.hlthalhph	...FasWLltpphaGs.al...csapc.p.+.uhshpsKhpullhhhlshulS.....la...hs...sh....hhl.+l...hLhllhh..hlhhahap...............	1	79	164	253
+2116	PF04305	DUF455		Protein of unknown function (DUF455)	Kerrison ND	anon	COG2833	Family	\N	25.60	25.60	25.70	27.00	25.00	24.70	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.50	0.70	-5.11	81	772	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	692	0	260	668	146	239.50	38	83.29	CHANGED	LtssDspcKsthspphtpta..tp.tph........shh..sth.........s......tPuRPtcPpLlsPpc..l.s+R.phso.cGRhslLHAlAH..IEhsAI-LAhDhlhRF....................................tsh.....Pps.......FapDWlcVAs-EAcHFsLLpp+L.pplGtpYGDhPAHsGLWcsuccTspDlhuRhAlVPhsLEARGLDsoPhhhp+lppsGDp....pusplL-lIhcDEIsH...................VuhGs+WF+alCp..pcsh-.........Phps..ap.pLl..ppahtstl+sPFNtcARtpAGhsps.ht.	...............................................................................pss.ppKsthspphht.thtstp.hth................t......th..........t....hPuRP..t..p..sp.Llt.Ppp...l....+R.phso.cup.ssllHAlAH..IEhNA..IsL.ALDsshRF.........................pshPtp.......FatDWlcVAs-Eu+HFpLLps+..L..ppLG............h..cYGDhP...........uH..su......L...........Wph...sp..pTtpDlhsRhAlVPpsLEARGLDssPhlhtKlppsGDp.....tssslL.-...lIhpDElsH...................VuhGs+W.a+alCp........pp.th.-...........................Ph..th....FppLl...pth.h..h..shh..+s...Ph..NhpARtpAGFspp.hp.s........................................................................	0	81	174	222
+2117	PF04306	DUF456		Protein of unknown function (DUF456)	Kerrison ND	anon	COG2839	Family	This family is a putative membrane protein that contains glycine zipper motifs [1].	27.60	27.60	27.60	31.00	27.30	27.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.90	0.71	-4.15	85	842	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	833	0	221	624	147	138.90	30	85.95	CHANGED	hllPlLPGs.lllasGhllasas.suhs....huhhhlslhsllsl.lshlhDalssshGs++hGuo+huhh....GuslGsllGhFlhs...Ph.......Gll....lGPhlGAhluEl.hppc.........s...h......ppAh+suhGuhlGhlsussh+hslslhhlshFlhsl.h	..............lhPllPGs.hllasGhllatas.....hsht....huhshhlshsllsl.lhhssDalusthts++hGuSKhu.h....uuhlGsllGhFhhP....Ph............Gll....lsPFlus....als....EL...lptp..........sh......ppAh+sulGoll.GhlsuolschhlthhhlhhFhhsh.h.....	0	75	163	208
+2118	PF04307	DUF457		Predicted membrane-bound metal-dependent hydrolase (DUF457)	Waterfield DI, Finn RD, Bateman A	anon	COG1988	Domain	Family of predicted membrane-bound metal-dependent hydrolases, based on Swiss:Q97LP7. May act as phospholipases.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.30	0.71	-4.89	181	3256	2012-10-01 21:01:47	2003-04-07 12:59:11	9	8	1920	0	845	2084	420	171.40	23	77.02	CHANGED	shoH.h.....hhGhsluhsh.ht................................htshhhhhhusluuhl...PD.lDhh.........thh.sptht.h............................................................................................HR.uh.THSllhhhlhuh......................................................lhhhhhthh........................hhhhhhhhhlGh...hsHllh.Dh..hTs.....h.Gst...lhaPh...................pptphths...hhhhhss........hhth...............................................................................................hhhhhhlshthhhtthh	............................................................................................................................oH.h.....hhuls.huhhh.h.t..h..................................ht.hthhh.sul.lsu.hL.......PD..lDph...............shh..spththl..t...................................................................................................................................H.R...G.....h.TH..S........l.l..hs.hll..sh.....................................................................................lhhhhhhth...................................h...hph.h.h.h.h.h.luh....loHllh.Dh.....hTs........h..G...lt........hLaPh..................................phph.ths.........hhh..h.hss...........hth...........................................................................................hh...............hhhhh.......................................................................................................................................................	0	248	566	724
+2119	PF04308	DUF458		Protein of unknown function (DUF458) 	Waterfield DI, Finn RD	anon	COG1978	Family	Family of uncharacterised eubacterial proteins.	25.00	25.00	26.50	67.80	22.10	18.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.64	0.71	-4.47	19	224	2012-10-03 01:22:09	2003-04-07 12:59:11	7	1	219	0	67	155	174	148.90	44	90.53	CHANGED	ccshpcIhpaltpsspssY+lhlGTDSQst.spTpFVTAIllHR....hGKGA.taaappphp++lpS....LRQ+IahETshSlElA........scltchltttsh...tshslElHlDIGt..pGcT+-LIpElVGhlhG..GapscIKP-SYuASslAD+aTK	...............p..VhpcIpsFlcc.D.PcshY..+LsIGTDSQs+..pc..sTcFlTAIhIHR....lGKGA.thha+pphpc+.to....LREKIahETphS.ElA.........pplh-lLt.hst....sshhhEIHLDIGs.....cGhTK-hIp-hsuhIpu....MG.hpAKIKPDuYAA.ShANRaTK..	0	42	56	61
+2120	PF04311	DUF459		Protein of unknown function (DUF459)	Kerrison ND	anon	COG2845	Family	Putative periplasmic protein.	20.20	20.20	22.20	21.30	18.50	19.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.94	0.70	-5.59	2	172	2012-10-02 11:02:24	2003-04-07 12:59:11	8	2	171	0	55	291	5	282.60	32	67.88	CHANGED	Psl.Ip+tps..h.ht.h.Phh.st.QhsIsphhP.hR.shl..sG.h.tstht-s..hs.thu.pPAstlstpssus..hlp-shhs.P.tlt.s...sE+.sssss.hhupsshp.hhsGDsp.p.hotshhp.htpp....thtItpspVs..hhshs.ha+hP+hh.shLshps....hAA..huhthsDh.s.FhDtsGuhssstssh.tpshc.+hcsslNl.ht.ph.hsahhthP.h+.htLst.hshh.tst.t...V.A.hssttshhhs..h..llsssthshuotlhssts.hhts.thsG.+hsIEGt...h.ph.PhhhsDhphs	.............................................................t.t.tspsssss............................................t..t.sss...+hhll...hGDhhustlu-G...L..ptsaspsPs...lhl..s.p..ssuso....GhVR...cDhh...sWsttl.......hhtt.....pp.ss.....lll....hlG...uN...D.RQ..shhs...s..s.s..p.......hpsp.ospWpp.p.Yp+Rltths.chl...s...cp...+...hP...l....lWVGhP...sF+sp..th.op..D..h.Lsh.N.pl.YRsuA..p.+s.Gu.pasDlWD.GF....VD..EpG.p..F.s.po.GsDhsGQpsRLRusDGls.hTps....G+RK..LA..aYsE+Pl....pchL.u.h.....s...tp.ht....l..sssp..............ph.s...spsh.hs....ss...L..ts.stc..u..s...Lh.G....s.s.st.........t..h..ps......ctp...........hhhtDh........................................................................................	0	13	27	35
+2121	PF01864	DUF46		Putative integral membrane protein DUF46	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein has no known function. It contains several predicted transmembrane regions, suggesting it is an integral membrane protein.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.22	0.71	-4.39	4	235	2012-10-02 14:06:56	2003-04-07 12:59:11	12	3	221	0	122	719	285	165.20	30	94.67	CHANGED	hhsll..LtslWalLPAYhANsSullhGGGTPlDhGKsahDGRRllGDGhTWRGhhuGlhsGsllGllQhhL............Golh.tlhLuFLLuhGAlhGDhsGSFIKRRLsh-RGpPAslLDQLsFlluALhhu..YP..ltslPh-hIlllhlITshlHhuuNIIAY+LGhK-V.W	..................................................hh.............hhPshhsNsss.h.l....h.......u........u.......tpPlDh.G+ph..........h.DG+..R..l....h...Gs...uKTa+Ghhs....ul....hh.Gs.lhu..h....l...s....h...l.....................................................................s...h.h...........l.hhu..hh..luhu.AhlG......DlhuSFlKRRlsl...p........c....G....t..................s................h...l....DQl.D.h.l.l.u.u....l..lhh......hh...........h..h.s..l..s....h.t...........h..lh.l..ll.ls..shl..HhssNhluYhltlKp..a..........................................	1	34	75	100
+2122	PF04312	DUF460		Protein of unknown function (DUF460)	Kerrison ND, Finn RD	anon	COG2433	Family	Archaeal protein of unknown function.	24.30	24.30	24.50	89.00	23.30	24.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.45	0.71	-4.65	30	115	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	115	0	80	116	4	136.10	41	22.10	CHANGED	+sh+utDVpVclcshh+c+lcFhsh.......st+.cchlIVGlDPGhoTGlAllsL-GclltlhSpRshspu-llchlhphG+PllVATDVsPsP-sVcKlupshsAsLYsPpccLol-EKtcLscchu.......phcssHERDALAAA	................p..h+utDVpVclcsh.ccplcFhsh.........tt+.+chlIVGlDPGhTsGlAllDLcGclltlhSpRshspu-llchI.chG+PllVAoDVsPs.PcsVcKlupsFsAhlasPccsLsl-EKpclscchu........hcssHpRDALAAA.	0	21	50	65
+2123	PF04314	DUF461		Protein of unknown function (DUF461)	Kerrison ND	anon	COG2847	Family	Putative membrane or periplasmic protein.	22.20	22.20	23.30	22.30	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.19	0.72	-4.40	175	1433	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1205	6	437	1186	538	110.60	30	62.80	CHANGED	lpcuasRs...............sss..ss.............................p......suAua.hslpNpuspss.pLluss.os.sAppsElHpphh.c...sGhMpMpplp.slslPAssslpL.....pPG....G.hHlMLhsLpps.l.ptG-plslTLpF..ccu......sp....lplp	..................................................................lpssasRs.....ss.s..st..............................................t......suuua..hslp..N.pu.........s.pss.pLluss..o.......s..susp..sElHphhh..p..........susM.+Mppls...slslPAss.slpL.....cPG.......G..hHlMLhsLcps..l.ptG-plslTL..pF..csu....tplpl.......................	0	102	259	351
+2124	PF04315	DUF462		Protein of unknown function, DUF462	Mifsud W	anon	COG3101	Family	This family consists of bacterial proteins of uncharacterised function.	21.00	21.00	22.20	21.60	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.10	0.71	-4.87	44	863	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	858	0	104	403	45	164.50	66	89.42	CHANGED	lFNpsFtppaNTpLVpGs-EPlYlPA.......ssp.......sap+IlFAHGaauSALHEIAHWClAGpcRRhL.DaGYWYpPDGRstppQspFEpVElKPQAlEWlhuhAAGhpFpVSsDNLsGs.psD....ppsFpppVtpQlhpal..p....................pG.lPtRAttFhcALppaYpss..ls.ppF.ht	.............IFNsCFu-.-FNTRLlKGDDEPIYLPA.......Dsc......VPYpRIVF.AHGFYASAlHEISHWCIAGcsRRcLVDFGYWYCPDGRDAQTQopFEcVEVKPQAl-WLFCVAAGaPFNVSCDNL-GD.hEPD...........RlsFQR+VHAQVhsYL....p....................pG..IPcRPA+FI+ALQsaYcTP.pLsAEpFs.hs...........................	0	22	47	79
+2125	PF04317	DUF463		YcjX-like family, DUF463	Mifsud W	anon	COG3106	Family	These proteins possess a P-loop motif.	25.00	25.00	26.90	26.90	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.57	0.70	-5.91	51	1031	2012-10-05 12:31:08	2003-04-07 12:59:11	7	2	996	0	159	638	61	429.50	59	95.04	CHANGED	lRLuVTGLSRuGKTsFITuLVspLLcs............u+LPlapusppGRlhuschtPQPD.sVPRFsYEstlsuLhsss..PpWPsSTRslSELRLul+Ypspsultphhss.uTLaLDIVDYPGEWLLDLPLLcpsatpWSppphshhps.tRtplApsaLsthpslD.sutsD..EtphpplAcsaTsYLpss+tpp.GhphlpPGRFLLPG-.LcGuPsLsFhPLsh.s........ppsscsShhshhc+RY-tY+ppVVKPFa+-HFuRhDRQlVLVDsLsALNtG.pAhpDhcpALsplhpuF+hG+s................ohLscLF.uPRIDKlLFAATKADHlpc-QHspLhuLlppL...lpcutppApFpGscscshAlAulRATppuhVppsGcplsslpGp.hts..........scpsslaPG-lPpch................sssshWppts.FpFhpFpPstl......ssstslPHIRLD+sLpFLLGD+L	.......LRLAVTGLSRSGKTAFITuhVNQLLshps.........s.......uRLPLhu...As...REpRLLG.....VKRlPQpDhulPRFsYDEuLspLh.....u.....sP..PsWPs..PTRGVSEIRLALRa+os.cu.LLRHh+.-.TuTLYL-IVDYPGEWLLDLPhLs.QDYhoWScQhtuLLpG.p.RuEhuspWhthsc..s....LD..PhAs..AD..EspLAcIAsuaTDYL+pCK...pp.GLHaIQPGRF..VLPGD.hAG.APALQFFPhPclss.t.....thhupAcKposhuML+cRapaYppKVVKuFYKsHFhRFDRQIVLVDCLQPLNuGPpAFsDMRhALoQLMpSF+YGp.R................oLh+RLF..SPhIDKLLFAATKADHVThDQ..HsNhVSLLQQL...lQ..-AWQpAAFEGIsMDCluLASVpATpoGhlc.hs.Gc+lPAl+GsRLsD..........GtslTlYPGEVPuRL.........................Pu..tsFWp..p.Q.G.FpF-uFRPpsh......clDcPLPHIRLDuALEFLIGDKL................................................................	0	25	67	110
+2126	PF04327	DUF464		Protein of unknown function (DUF464)	Kerrison ND	anon	COG2868	Family	\N	20.40	20.40	22.10	22.10	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.51	0.72	-3.78	58	1433	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1398	14	197	712	9	103.00	33	94.18	CHANGED	MI+lphp+sp.splhuFploGHAs...........hu......chGpDI.....VCAuVSulshsslNul-plt.phcsphph....psGaLplcl.s.....ppppsQllLcshhluLpsltppYs.ca.....lpl	...................MIpsshp..csc...tG....p....ltuhphsGHAs.....................hu...-a..Gp.Dl.....VCAuVSslshssl.Nulppls...sh...c...s...p...lcht....cuGalpl..cl..sss...................pp......cps...QlllcshhluL.ps.lp..c..p..Ys.-alp.................	0	90	142	168
+2127	PF04325	DUF465		Protein of unknown function (DUF465)	Kerrison ND	anon	COG2841	Family	Family members are found in small bacterial proteins, and also in the heavy chains of eukaryotic myosin and kinesin, C terminal of the motor domain (Myosin Pfam:PF00063, Kinesin Pfam:PF00225). Members of this family may form coiled coil structures.	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.43	0.72	-4.26	175	1757	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1278	1	425	1015	380	49.40	33	66.23	CHANGED	hscLtpcHpp.LDppI..pphppp...s..s.scshplpcLKKcKLpLK.........Dclhplhpp	.......htpLhccHsc.LDccI.pphEss...s...s..ss..sh..cl..pc.LKKcKLpLK.........Dclhplhp...........................	0	96	245	335
+2128	PF04328	DUF466		Protein of unknown function (DUF466)	Kerrison ND, Eberhardt R	anon	COG2879	Family	Small bacterial protein of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	30.10	25.70	20.80	23.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.34	0.72	-4.14	41	1692	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	1243	0	200	511	13	64.60	52	94.47	CHANGED	hhpclpphh+...hhtpsh+hhVGlP-Y-sYVpHM+ppHP-c.PlMohcEFFR-RQcARYuusuu...RC.C	................MFssLupstKYLGQAA+hhlGlPDYDNYV....E.HM+psH..PDp....s......sMoYEEFFRERQ-.ARYGGcGus...RC.C.........	0	32	93	150
+2129	PF04326	AAA_4	DUF467; AAA_div; 	Divergent AAA domain	Kerrison ND	anon	COG2865	Domain	This family is related to the Pfam:PF00004 family, and presumably has the same function (ATP-binding).	25.30	25.30	25.40	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.83	0.71	-3.96	163	2671	2012-10-05 12:31:08	2003-04-07 12:59:11	9	56	1473	5	706	2349	272	120.30	21	27.02	CHANGED	Esppl.EaKpshttstp....................lhcslsAFAN..s....t.....G.GhlllGlp..D...........stp...lhGl.......................tpttpttphhpp.ltptlpPt...........lph.php.......hthpsp...............................................................pllhlp......l.puspts.......................http....sphYhRhuspspt.hs	....................................Esppl.EaKpshpp....p.....................lhcslsA..FAN....s.........p.........G..Ghlll.Glc....D.........ssp...........lhGl............................p.p....p.p.th.p.t.h.t....p........h.t.p..php..s...............lt.h....phph...........h..p..h..p.sp...............................................................pl.l.hlp...l.tutpts............................ht.p.............sthahRhssts....t...................................................................................................................................................................	0	253	490	579
+2130	PF04318	DUF468		Protein of unknown function (DUF468) 	Finn RD	anon	DOMO_DM06450	Family	These conserved ORFs probably are probably not translated into protein [Personal communication, Val Wood].	25.00	25.00	83.00	82.90	20.10	17.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.11	0.72	-3.42	4	21	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	3	0	12	21	0	79.70	78	74.39	CHANGED	hHGTCLSGLYPVPFTHpsHcYPHFsIYISFuGPKYCITALNshlIPLLpHI............LTsphIaTYhNIspKSP.KpPKHKNILlFN.sp	.MHGTCLSGLYPVPFTHpuHDYPHFNIYISFGGPKYCITALNTYVIPLLH+I............LTTQFIaTYsNITpKSPlKSPKHKNIL.FNpNT...	0	12	12	12
+2131	PF04320	DUF469		Protein with unknown function (DUF469)	Finn RD	anon	DOMO_DM08606	Family	Family of bacteria protein with no known function.	21.90	21.90	23.50	23.00	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.35	0.72	-3.23	37	852	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	825	0	116	317	11	100.30	61	90.89	CHANGED	RRLRKKL+lsEFQELGFplshpaccshst.-phDshlDpFI-.hIEspsLsasG.uG...phtaEGhlssp.chG..psTEEcRtsVctWLcu+s.lpslclo-LhDhWa	..............RRLRKKMHIDEFQELGFSVuW+FsEGTS-.EQIDcTVD-FIsEVIEPNcLAFDG..SG....YLsWEGLIChQ...cIG..KCTEEHpAlV+KWLEtRp.Lc-VcsSELFDlWW......................	0	12	33	77
+2132	PF01865	PhoU_div	DUF47; 	Protein of unknown function DUF47	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes prokaryotic proteins of unknown function, as well as a protein annotated as the pit accessory protein from Sinorhizobium meliloti Swiss:O30498. However, the function of this protein is also unknown (Pit stands for Phosphate transport). It is probably distantly related to Pfam:PF01895 (personal obs:Yeats C).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.29	0.70	-5.17	9	1815	2012-10-02 11:27:25	2003-04-07 12:59:11	11	7	1654	7	546	1275	457	205.00	24	94.91	CHANGED	hhhlFtpss.+plhcHhchlspslhthtchhcuhhcGshcpsEcltc-lsphEccADpl++-lclpltpuhFLPssRsDllcllc..DclhDshEcsAhhlhltc...thPc-hc--hhthhppolcshchltcslctl-p.l-suhp.........llpclcplEccsDtlptclhctlas...psh.sshchhhhhpllcplusluDpuEDsu-clpllhhc	................................................................................h...........t.h.phhpths.p.sh.pth.hp....hh...p.t.h.h...p...t...s......p..c...h...p....ph..t....pplpphEccuDplp+clhp.cLsp......s......F....l...TP.l-...R.....-D....Ih..p.L.ssph......Dclh...Dth....c.c.s...u...t....h.h......h...hp......l.........p....t.h...pp..t....hh..phsp.hlh....c.us.pp.h......p.p.s..l..p.t.L..sp.h.h...p.ss...h.p....................phsh...c..lcplEscsDplhcphh.p.c.LFs..........tp..t..h....-...s..l..pl...l...th.+.cIh.-tlEcls...DpspcVAstlEsllh........................................................................................................	1	177	348	453
+2136	PF04322	DUF473		Protein of unknown function (DUF473)	Waterfield DI, Finn RD	anon	COG1935	Family	Family of uncharacterised Archaeal proteins.	25.00	25.00	103.10	102.80	20.80	18.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.19	0.71	-4.46	17	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	54	0	43	55	1	117.30	33	92.22	CHANGED	MchhuLTGIu.psIp-LhpstlRTlEl+SspNlhslpph.psG..DhlFlTssshcDlhsGTpGllApVhphplshp+.h..tps.hhEE+EhhsuRlQLchlGhu+lh.clhppchhpshhV..-	.MchluLTGIucpsls-Lh+splRTlEl+SspNlhslppl.psG..DhlFlTssshpDlssGTpGlIuclhplplspp+.h..tps..h-E+EhhsuRlQLchlGhu+lh.cVpppphhpsshV.........	1	8	22	33
+2138	PF04536	TPM	DUF477; Repair_PSII; Phosphatase;	TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase	Waterfield DI, Finn RD, Bateman A, Eberhardt R	anon	COG1512 & Pfam-B_18715 (release 10.0)	Domain	This family has a Rossmann-like fold. It has phosphatase activity [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.21	0.71	-10.28	0.71	-4.24	162	3085	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	1821	5	879	2585	289	124.00	22	42.17	CHANGED	hLo..sspppplpptl........................pph.Epposs................plhllhh.sh..s............................................................................................................pshcphAhchapp.ht...ls..pptpss.....GlLlhl......uht..-+..p....hpl..su..........tGlpsh.lscshhpp.llpsh...hsth+pspaspulhsulptlsphl	................................................................................Lssppppplpp.tl.........................p.ph...cpp.s..ss................plhVlh..l.ss.h..ts...........................................................................................pshcpaApclapp.ht......lG......ppp..pss...............GlLlll..........uhs......-R.p................lpIp.s.G..............hGlcsh..l.sD......s...hhsp.I.lpph......hsth.+.....p.s..c...astGlhtulpsltt..........................................................	1	272	591	767
+2139	PF04334	DUF478		Protein of unknown function (DUF478)	Finn RD	anon	DOMO:DM06402;	Family	This family contains uncharacterised protein encoded on Trypanosoma kinetoplast minicircles.	25.00	25.00	99.60	96.90	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.32	0.72	-4.12	2	2	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1	0	0	4	0	60.50	64	97.58	CHANGED	MGVQh.sYTNPVLFWGlFEVRGTSKGVGVILTRFF...............l.Ih.lhlhhGF.pts.a	MGVQh.sYTNPVLFWGlFEVRGTSKGVGVILTRFF...............l.Ih.lhlhhGF.pts.a	0	0	0	0
+2140	PF04336	DUF479		Protein of unknown function, DUF479	Mifsud W	anon	COG3124	Family	This family includes several bacterial proteins of uncharacterised function.	21.40	21.40	21.40	23.10	20.80	19.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.51	0.72	-3.93	55	920	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	913	0	158	494	113	106.50	46	55.17	CHANGED	aDHaLApcWppap.sp.P.....LspFsppsYptLpst.....tshLPt+htplhsthhppcWLsuYpchsslppsLpphup.Rhs+ss..Lssuht-lpp.pYppL-psFhsFYPpLhsa	..............................WDHFLuRHWsplos-..P.......LppFlsaAppplhsh.....lPcpPsRFlsL.NsYLWuEpWLs+Yc-h-a.I.ppVLsGMA....s.RRP....R....Lcu....L.ps........SahDL-s.HYssLEscFhpFYPchMs.p....................	1	33	79	125
+2141	PF01867	Cas_Cas1	DUF48;	CRISPR associated protein Cas1	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein.  Cas1 may be involved in linking DNA segments to CRISPR [2].	20.20	20.20	20.30	20.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.77	0.70	-5.33	140	3143	2009-09-11 00:29:59	2003-04-07 12:59:11	11	9	1958	26	807	2515	107	209.90	20	81.31	CHANGED	slalpspGshLphcssslhlpp....................ppc.........................lPlppl..cplhlhGp.lslosthlphhscpsIsltahstp.....G.pahuphhs...........thstsshhph.tQhpthhspptpltlA+phltuKltNttphL.....+htppp...............hpphhpplp.t......h..hpph............p.slsplhGlEGpuuphYapshs.pll................................................p....sapFp....tR......s+RP...P..pD.lNAhLSaGYulLhspshsslhtsGL-PhlGaLH.p...sp.s+.oLuLDlhE.FRPhllDchlhpLl...scphlp.tpcF..t.t...............sshLscpu++phlptapc+	...................................................h........t.lphtttthhh.p..................................ptt...............hhtlPltpl..t.lhl.st.stlotthhthhsp.sh.lhah.st.t.....s..h..hhth...............ttps.h.hhhp.hph..s.t.t...phtlspphht.ph...............................................................................phtplhsh.Eu.t.hsp.hathh...........................................................tht.ap....t+........p.............ts...h..Nthlshu.s.hlhs.h.ttlhhhGhsshlGhhH.......p.t..uhs.Dlh-.h+s.hss.hs.hthh....t.......................................................h.............................................................	0	307	576	708
+2142	PF04337	DUF480		Protein of unknown function, DUF480	Mifsud W	anon	COG3132	Family	This family consists of several proteins of uncharacterised function.	25.00	25.00	30.30	27.40	24.00	21.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.80	0.71	-4.35	53	923	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	913	1	173	537	52	150.80	62	67.31	CHANGED	LoshEuRVlGsLlEKphTTPDpYPLSLNuLssACNQKSsR-PVMsLoEu-VppuLDpLpp+pLlpp..sshGuRVsKYcH+Fsps....LpLsstphAllslLLLRGPQTsGELRoRopRhapFsDlspVEssLppLtp+p....ssLVscLPRpPGc	...LTAhEARVIGCLLEKQVTTPEQYPLSlNullTACNQKTNREPVMNLSEuEVQ-pLDsLl+R+.hlRs..SGFGsRVoKYEpRFCNoEFGDLKLSuAEVALlosLLLRGAQTPGELRoRuuRM.a-...FuDhuEVEusLEpLAsRE.....sGPhVVRLsREPGK......................	0	32	81	128
+2143	PF04338	DUF481		Protein of unknown function, DUF481	Mifsud W	anon	COG3137	Family	This family includes several proteins of uncharacterised function.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-10.91	0.70	-4.61	121	1242	2012-10-03 17:14:36	2003-04-07 12:59:11	7	4	1038	0	283	927	368	208.30	31	76.69	CHANGED	schGht.hsoGNTcosshsuphp.hphcts.pachph.phph.h..............p.............pss.sp....s........oscpahhshphcaph..scphahaupspacpDcFs.................shch.ctshusGhGaphhs.scpt...pLslcsGsuaphp.........chpss.............pspsph....hspsshsa.paplscshphppphph...........h....sssshphps-suLpspl..sss..luhcluhphcasops.ss.ut....cpsDophshsLsYsF	.......................................................................................................h.phGah.upoGNTc...os.S.l..suc....ss..hsah.st...pp...tasl..husupp.............s..................sss.sc.........c.............ou-+assuscscapl.......s-hs.......Yl.a..G.pusahs...D+as.....................................................uYc....p.+.ss.l.s.uGhGhQhls..sshp.......shch..E...hGPGhRas........cascs.................................sscsps......luhuussY..ta...p.l...o...-..s.scF..s..pslol..................................h.........u.sp.cT....slsSE.....su....LsssI....scc....huLKluasl.sasopP.Pp..us.........c+oD.ppoolsLsYs.........................................................	0	92	164	226
+2144	PF04339	DUF482		Protein of unknown function, DUF482	Mifsud W	anon	COG3146	Family	This family contains several proteins of uncharacterised function.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.14	0.70	-5.59	99	853	2012-10-02 22:59:21	2003-04-07 12:59:11	7	7	784	0	330	1004	1212	354.00	38	92.18	CHANGED	ulspIssspWDul....s...............s...................s.......tsPFlpasFLsALEpSGssss..cTGWtPpHLslp.cs.......s.....pl....................lussPhYlKsHShGEYVFDauWA-AapRsGhcYYPKLlsulPFTPssG.RlLht...st.cpsth.tpsLhpultphspp....pslSShHlhFss..ts.-tth...........hp..ptGh...............hpRhspQFHWpN......pGYpsFDDFLusLsS+KRKsIR+ERcps.tppGlplchLpGs-l..spppW.ctFapFYpsThs++..WG.pPYLo+pFFphlscp.hs-pllLlhA....c............+.sGc..lAuALshh.......u.....u-sLYGRYWGshEc..hshLHFEsCYYQuI-aAItpGLpphEuGAQGEHKluRGahPssTaStHaltcsuhcpAlscaLppE+ttlpthhctls.pth....PF+c	....................................................................................t.lsplstspWsul....ss........................................t.sPFlp+sFLpALEp..SG..ss....ss..poGWtPpHlslhcs.....s........pL....................................................lussP....h...YlKsH.ShG..EYV.FDauWA-A.apRt.G..h..pY..YP...K.Lhs...ulPF...T.Ps..s..Gs.R.lLst.......t...p...t...t.th...tttLh.tulhp...hspp.....ps.l..SSh...H...l.h.....Fss.....t...s.....-..t...th..........h..p.....p.....t..Gh..................................ht.Rhsh...Q...F.HWp.........N........................pG.......Y.....tsFDDFL.s.s.L..su+.KRK.slR+ER+ps...t............t....t.Gl...p.hchl..p.G.scl...sp.t..pW.chFaphYtsTh..tc+....hu...pP..Y...L......s..c.......pFFphlu..p.p...h.....s.....-.p..llLlhA...c........................c..s..G...c...lAuAl.shh.....u........................sssL....Y....GRYW...G......s...h...c..c......h...s...t.....L..H..F...E...s.C..Y.Y...Q......u.........I-aA.ItcGLpp.h.E....u.G.......A....Q....G....E..H.....KlsR..G..ahPsh.T.aShH..als....csuhppAltcaLppEpttl.pthhptl.p.pt..Pa+..................................................................................	0	81	191	269
+2145	PF04467	DUF483		Protein of unknown function (DUF483)	Waterfield DI, Finn RD	anon	COG1790	Family	Family of uncharacterised prokaryotic proteins.	25.00	25.00	39.40	33.20	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.48	0.71	-4.07	4	23	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	23	0	16	23	3	120.50	47	61.63	CHANGED	h-hQI.lsc+hpshlRs..tl-shIs...sELGlhR.h.stp.G+LLsYP-CCl+SasEspR.hsh-tcaLtEsuEhs...h.....hGhhhIhhP....SsFIPCSLcCp-AlccshIuhhh+-EFcchh-Lcc.Lh	..........................LchQIEIVcKYpscVRP..AIDPhVS...oELGIYRRLD.DhElG+LLsYP-CCl+SFsEssR..huIDp-HLKElEchchc.........................s..hYAIlLP...............SGFIPCSLcCccAlcptLIuhlsccpac+lLcLEcEL.............	0	4	8	12
+2146	PF04340	DUF484		Protein of unknown function, DUF484	Mifsud W	anon	COG3159	Family	This family consists of several proteins of uncharacterised function.	24.20	24.20	25.30	24.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.30	0.70	-4.88	6	1222	2012-10-02 14:34:25	2003-04-07 12:59:11	7	4	1147	2	271	774	583	214.30	37	92.58	CHANGED	ts.pssLsspsVs-YLppHP-FFhcascLltcLslP+psussVSLschQLsRtRp+hccLccclstLhs.AtsN-plFhchhtLphsLhcApSLsDslppl-phs+chhhtshspLlLhsDsth..u.u......lupcshp.sthspLsscpshhGhLphs-thhLas-.-ApplGSsAll.Lu....pt.hGllAFuSpDspHFpsuhGT.FL+alAplLschLc..RWss	.....................................ttLss.csVs-YLhcpP-F...Fh+pschlcsl....c...l...P...H....s...s...p...u...sV.SLVEhphtRhRp+lc..hLE-phshLMcpAtsN-sLFh+lhpLptpLh.sA..s.S...Lp-hl........hp.h...pchsR-.lhhs.s...s..sL...+.L...a....s...D......p........hp......h........u...........u.......h...........p.....h...s...l..u....c.........p..s..h...c....s.........l.p....h.....p........+........L......u.....t........p............p........t.Y.....LG......s...L.s....s............s...E...h....h....h...l..........h.........s.........p...A......p....tl................G............SlAhshLs................ssu.s...l..GlllhuScDspHapsu.GT.hLpplAh.hLsclLp..Ra..p.............................................................................................................................	0	52	138	206
+2147	PF04341	DUF485		Protein of unknown function, DUF485	Mifsud W	anon	COG3162	Family	This family includes several putative integral membrane proteins.	28.00	28.00	28.20	28.00	27.80	27.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.91	0.72	-4.27	132	1454	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1255	0	378	871	80	90.20	38	81.72	CHANGED	lpssPcFpcLhpcRppFuhsLohhhLlhYauallLlAassshLup.ls.G.slolGlslGluhhlhsallTulYVp+ANppaDtlspplhcc	.............lpssscFp-Llc+Rp+FuhhLollhLshYhuFlLL.lAauPshLu.sPlt.G.slThGl.s.lGlGlI.lhoFlLTulYlh...+ANscFDclsppllc.................	0	96	224	312
+2148	PF04342	DUF486		Protein of unknown function, DUF486	Mifsud W	anon	COG3169	Family	This family contains several proteins of uncharacterised function.	25.00	25.00	41.40	41.30	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.55	0.72	-3.99	4	583	2012-10-02 19:55:49	2003-04-07 12:59:11	7	1	574	0	179	409	45	109.10	55	92.52	CHANGED	LhosLLLhsSNVFMTFAWYGHLKphss+PhllAsLlSWGIAhFEYLLQVPANRIGassLoVuQLKhhQEVITLhlFVPFSVaYLppPL+LsYLWAuLCllGAVYFhFR	...h.hsllLLlhSNlFMTFAWYGHLK.....h..h.........s......s......p......P.....lh.....hslLlSWGIAhFEYhLQVPANR.I.G.ap....s....a....osu..QLKlhQEVITLsVFssFo.V.a.Yh.p.E.sL+hsaLhAhlhl.luA.VaFlF+........	0	56	129	152
+2149	PF04343	DUF488		Protein of unknown function, DUF488	Mifsud W	anon	COG3189	Family	This family includes several proteins of uncharacterised function.	22.20	22.20	22.20	22.60	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.63	0.71	-3.74	219	2338	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	2035	0	577	1579	120	111.60	33	83.11	CHANGED	plcchhc...hhpssGh+......lLVD.RhaPR.....G.hsK-slphsl..............Whpc.lusspclRchat.tt....p...hsphhcpYtpclps...........pslpcLtp.hs.ppt....lsLlhut+-.p+.......sHthlLt-h.L	.............................................p.hcRlY-...htps-GhR......lLVD.RlWP..R..........G...lpK.pshth..D.....................WhK-.luPSs-L.....Rc.hap..p-s...c.................aspFtcpYttELtp.p...t....................pthccLts.ls...p...pp.......slsLLauu.+.c..ppp.......NHAhVLt-hL...................................	0	172	365	488
+2150	PF04356	DUF489		Protein of unknown function (DUF489)	Kerrison ND	anon	COG2915	Family	Protein of unknown function, cotranscribed with purB in Escherichia coli, but with function unrelated to purine biosynthesis [1].	22.90	22.90	24.60	38.60	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.09	0.71	-4.71	56	1032	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1015	2	152	528	101	191.80	55	92.10	CHANGED	-pslALAGlhQAupLVpplA+pGps.-pss.....hpsslpSllppsPs.....sshsVYGspp....sL+hGlcsLhstLs.......tspspss-lsR.....YhlullsLE+KLs+ssshhspLupRIsplpcQhpHF..sh............tc-slluslAulYsDsISsLusRIQVpGsPphLQpststp+IRALLLAGIRuAVLWRQlGGpRhpLlFuR+pllpp	.......DITLALAGICQuA+LVQQLA+pGcC.Ds.DA.....LcsSLsSllshNPu......STLuVFGGs-...tNL+lGLETLlusLs..........ssppuhsuELTR.........YsLSLMsLERKLous+sAlssLGsRIstLpRQL-HF....DL............ps-slhSuhAuIYlDVISPLGPRIQVTGoPulLQsPpVQuKVRAsLLAGIRuAVLW+QVGGuRhQLhFSRp+Lhs.p....	0	30	66	113
+2151	PF04357	DUF490		Family of unknown function (DUF490)	Kerrison ND	anon	COG2911	Family	\N	20.40	20.40	20.60	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.40	0.70	-5.36	151	2461	2012-10-03 05:41:17	2003-04-07 12:59:11	8	21	2009	0	647	2270	560	348.80	22	27.68	CHANGED	pp..htst....sssGplplsG.....slsh..................tthp......hsLsl.ph.pp..htlhpssthp.......sp.l.sus...lplsG..sh......shplsGp..l.plspuplpl.phs..ssts.s...........................shhhhttt...............................t..h.h.h...thslplph.....ss..........plhl...............cu.u...l..csphs.G.sLpl..........sts.....ss.hthsGplplh.c.Gp.hph.....h.upphpl.p.pGplsas.G.sh....pPhLs.lpAhpps...........................ss...........pls.lplsG...ssspPp........lph.....................p.S...pP.................s.h......................sps-lluhLl.hGp....shsshu.............ttsthssuhuslhts...sshtshh.sp.........ltpt.......hGl...s.slsl.......sstt.........t.......................ttshslplGphl.ssclhlsht..hsh.ss.t...........tphp......lcYpls...pphplcups..s................tt......tlslhaphca	...................................................................................................hht........stpGpl.pl.sG.shsh........................................tthpshp.....hp.l.sh...pu...sp...........hp..l...hs...sshhp..............hp..l..sss...........ls.l.pu......ssp......thslsG.p....l...sl...stup....l.s.l.phs...ssssss..........................-l.shlsps......................................................................................................pt.......ts.hsl...phslp.lp.l....ss..............slpl...........................suhG............l..cupLs..G..s....Lpl..............sts...........ps...hthsGplsl....c..Gp..ach..................h.Gpclhl..c...cG...p..lh.....Fs...G.s.............pPhLs.lpAhpps....................................sl........................hss.l.plsG..........ss..pPp.........hpl................................................................h..S..pP..........................s.h........................spppsLohLl.hGp..........shssss..............p.ssu.hsshh.h.u....s...sphh.sp.....lsps...........hGl...s..slsl.................so.ps......................................sssspls.lut.hl.tspl.l......phs..huhhss.s..............................phs..........lcYpL.....plhlpuhs..s.....................sp....ulsl.hYphca...................................................................................................................................................................	0	213	426	555
+2154	PF04361	DUF494		Protein of unknown function (DUF494)	Kerrison ND	anon	COG2922	Family	Members of this family of uncharacterised proteins are often named Smg.	20.60	20.60	20.60	22.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.91	0.71	-4.55	48	950	2009-09-11 06:38:14	2003-04-07 12:59:11	8	1	940	0	158	376	87	154.50	57	99.23	CHANGED	MFDVLhYLFEsYhcs...-.-hpsDp-pLsc-LtcAGFcppEItcALsWL-sLushp......................tshhtsssssoh.RIYospEhp+LsscsRGFlhFLEphsVLsspoREhVIDRlMuL-ssplsL--LKWllLMVLFNhPGpEsAathhE-Lla-pps...thlH	..............MFDVLMYLFETYIHs..........EAELpVD..QDcLpp-Lo-AGF-+EDIYNALhW.LEcLA-hQc..................s.scPht..hso...D.PhSh..RIYTsEEs-RLDssCRGFLLFLEQIpVLshETRE.MVI-RVhAL...Ds...sEF...-L-DLKWVILMVLFNl....PGsENAYpQMEELLF-ss-.GhLH...............................	2	38	88	123
+2155	PF04362	Iron_traffic	DUF495; 	Bacterial Fe(2+) trafficking	Kerrison ND, Mistry J	anon	COG2924	Family	This is a family of bacterial Fe(2+) trafficking proteins.	20.90	20.90	24.90	24.90	19.20	18.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.95	0.72	-4.55	65	1349	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	1339	3	260	617	383	87.20	59	96.06	CHANGED	Mu..RsVhCtKLp+EuEGLDhsPaPG-LGc+Ia-sVSKcAWppWhc+QTMLINEp+LshhDscsRcaLpppM-+FhFsps.sspspGYsPP	...........................MoRTlFCshLp+EAEG.DFQ.YPGE.LGKRIaspISK-AWupWp++QTMLINEK+LNMMssEcRKhLEpEMssFLFEGc.-..s+lEGYsP................	0	61	135	203
+2156	PF04363	DUF496		Protein of unknown function (DUF496)	Kerrison ND	anon	COG2926	Family	\N	21.50	21.50	22.30	23.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.10	0.72	-4.17	13	780	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	775	0	75	202	1	94.80	77	85.78	CHANGED	hpsVLEhVRhhRRKNKLpREIsDN-+KIRDNpKRVhLL-NLh-YI+ssMShEEIpsIIcNM+sDYEDRVDDYIIKsAELSKERRElS+KlKphKc	...................FQDVLEFVRLFRRKNKLQREIpDsEKKIRDNQKRVLL.LDNLSDYIKP..GMSVEAIQGIIASMKuDYEDRVDDYIIKNA.ELSKERRDISKKLKAM..GE..	0	6	23	50
+2157	PF04365	DUF497		Protein of unknown function (DUF497)	Kerrison ND	anon	COG2929	Family	\N	23.70	23.70	23.70	23.90	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.80	0.72	-4.06	96	916	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	614	1	261	806	130	76.80	33	83.44	CHANGED	WDps.KsptNhpKH.GlsFt.-AttlF..cshtlhh.................Dtccs..sEpRa.hslGh...ss+llhVlaThR....ts......tIRIISAR+As++Ec	....................................WDts.KsppNht..K....H.GlsFp.-Attl.F..ss..tlph................pDtpp....sEtRa.hslG.....hh.........st.p..llhV.saT.R........sp........hlR.lISs...R+Asc+E........................................	0	68	179	219
+2158	PF04430	DUF498		Protein of unknown function (DUF498/DUF598)	Waterfield DI, Finn RD	anon	COG1504	Domain	This is a large family of uncharacterised proteins found in all domains of life.  The structure shows a novel fold with three beta sheets.  A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid [1].	20.90	20.90	20.90	22.80	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.42	0.72	-4.51	101	971	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	868	12	443	853	223	109.00	28	70.39	CHANGED	lpuY..usGthpl.s....shp..........apuulllhPsuh..hsW..s..............stphppls.......hcchshlhsh...ps-llllGTGtc..hthlssplhptl.pptG..lslEsMsTssAsRTYNlLhuEs..RpVAAALl	.................................................................lpuYussthpl.s.....shp..............hps..s..lll.hs...suh..hsW..p.................................................sps.ppls........................psh.shlhth......p..s....-llllGT.Gtp...hth..l.s.sp....lhthl....ppt..G..IulEsM.......sTssAs+TYNlLhuEs..RpVuAALl..........................	0	132	244	338
+2159	PF00674	DUP		DUP family	Bateman A	anon	Pfam-B_99 (release 2.1)	Family	This family consists of several yeast proteins of unknown functions.  Swiss-prot annotates these as belonging to the DUP family. Several members of this family contain an internal duplication of this region.	21.10	21.10	22.30	22.00	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.64	0.72	-4.09	32	469	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	27	0	183	427	0	103.60	29	52.60	CHANGED	hlhhts.....hhhss.h.hhllhshhhhhhhhhsF.sht....hhsp-achphLhElIsc+Pu.tuc-WcpIAhpMNpYLF-cclWpT.YaFassp-CppaFpphltthhstKps	..........................................................hh............h.h.hhhhhh.hhhhs...h..h.h...hh..lhsh.php.......hsp.ph...hphlp-llpppPu..sspsW-tIA...tphNpYLa.-p.+hWpo.t.h.aFasutcCpphFpphlhp.hs.p..p................	1	36	47	123
+2160	PF04465	DUF499		Protein of unknown function (DUF499)	Waterfield DI, Finn RD	anon	COG1483	Family	Family of uncharacterised hypothetical prokaryotic proteins.	21.10	21.10	25.60	24.10	19.70	20.90	hmmbuild  -o /dev/null HMM SEED	1036	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.71	0.70	-13.89	0.70	-7.00	5	220	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	188	0	107	235	48	429.10	21	44.17	CHANGED	PcALcDcEV....L+sYcs-KREplcElu-hIcsl..ulclVlVYGKss..lPpPs+PL-hsst+lKTlWGYIAapLG+YElVEcsD+NLTsPshElL+-LlpGc+VLlLIDEIuDYlDslppSusEE-RsYucNVusFLD+LApALos...SpSlMVITIPMEcEGts..lKspcEYcR..-lVRulh-AVoRVuGtclYoPV+h.GRcsELlEVLKKRIFK+lDcsE+c+sLp+L......REshus.+EIFG-sSpFhcEIccTYPFHPEYIpVLRsIIERls.LQRTRDLIRI...TRIVlRc.LlcuhE....sPsLIMPaHIDLs--cI..+GlLFucpocYuDYtoIa-s-lIs-EKl...Kchu+PELu+IILoYIFL+TYPaDS.....................Ppshs-FPTsccIARuVYEPEhFcpppWlPsDIKDslEEI+uSl+FlaLs...++Dus..aWFWRlANVochVcSKsEELIEos+G-VhspLVKp.lc+Ll+EuKSlcpuRu+tsps......caVsFFcspsVIVoK..-PQElhDos-YKLhVlVpDDV-EDhLc+lIFhhsousRTY+NTVVVlYlusc.uM..........................-oLlEhpAplhAC-cVM-cI+EhY.........uKYGKDVlcIQ+ohVc-I+c+ALED.LENQIlpsFR+VAYPctDG....l-pspAsASSKSVlENVYSALsS+..GKIV.-EFDFEpLtshLc-.Vslcl.+sEGYsVSELhNlIpS..NPcLPMIcpccLh-AIK-AVccL-IG.IERcG+IaFK+IY..KEIPch.--E+GcsPusVR..........cDVILPt.....-EALpRQlpELLc-EK--It-+sGp+Ycl+h..............WYE..IYLPppNhplPL+slV...scEscV+DE..ptlhaGaIVE++EEcpIl+GEF-..LpVucupIcGKPG-sV-lcV+lpPlGDtchsVELsosaG-LsoccVpL.EGpsl+lpW.phplsc.+c.shIcuKS.-s+ttphElllIPKlEp-IlEVcElcEpHKGslLlSI+..Slcs....lDoL-pIsc.aEGs........lsGSLEl.....EcPlWcVpF..cssDhcVFcaIluElc-aLGSpsplc..V-lchSEElhINDLlhEKL+PLsG+VKF+lKKG-.pc	.........................................hhh.shs.......................................................................................h...pT.lWG-lAhQL.......G...........t.............ap...h....l...tp.t.Dt.p.t.hs...P.G.tphlpc.Lh.....p....t.....p.P..sLILlDElssYhc......phh.tst..s.h.s..sss.htpph.sF.lp....s.L..o.c.A.sps.....s.p.s.h.lV.l.o.ls.........s...s.................p...t..t..............................tt.....t...h....t....p.........................................thl.ppL....pp....hhs.Rl.t....t..h.p...Ps.........stp.p..hacIlR+R...LF...p..p.......l.......s.t....p....t......t.......p...p....sh....pph...................tphh.p.p............p.............h....s.....p.........p...s.....p....a.........tcc.lpp.......uYPhHPc.lh-hL.h.c..h...ssh....s.FQRTRGlLRl...hutll+p.La.pp.tp...............ts.LIhstp....lsl.ss....pl..p.......h.h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ttttt....................................................................................................................................................................................................................................................	0	43	78	94
+2161	PF04366	DUF500		Family of unknown function (DUF500)	Kerrison ND	anon	COG2930	Family	Proteins in this family often also contain an SH3 domain (Pfam:PF00018), or a FYVE zinc finger (Pfam:PF01363).	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.40	0.71	-4.69	74	1081	2009-01-15 18:05:59	2003-04-07 12:59:11	7	22	629	0	603	1018	204	114.40	29	34.00	CHANGED	hsG.uuhGh.QlGs-hoDhVhllpspculcshhp.uphoLGussSlAAGPlGRsupussssth....u....................................................................slaoYS+o+...............GlFAGloL-Guslhpcp-s..NpcaYG..........plsspcILtGps.s..........s....ss..uptL...hpsLpph	..........................h.susuhGh.QhGsp.tchVhlhpspcAl..c..sF...pp...ssho.lGuss..........o..........lA..s.......G.s.lG.t..sup.s.ss..s.sst.....u...............................................................................slh.s.a.s.p.o.+...............GLauGlol-Gohlh.p..tt...s.thYt...........h.....l.h...t...............................................h................................................................................	0	172	359	505
+2162	PF04417	DUF501		Protein of unknown function (DUF501)	Waterfield DI, Finn RD	anon	COG1507	Family	Family of uncharacterised bacterial proteins.	22.60	22.60	23.20	23.10	21.70	22.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.73	0.71	-4.33	43	550	2009-09-11 10:23:03	2003-04-07 12:59:11	7	4	523	0	173	424	260	123.50	47	54.26	CHANGED	VutRCssGhPsV.lpotP.LsDG........................pPFPTlaaLTsPplsttlS+LEupGhh+chpccLspDt-LtstatpAHcpYltcRpplh........................h.tlssh.usGGhss......+....VKCLHshlActLAs..ssNPlGchslsh......l	..................................................luhRCs.sGpPsV.ltTtP+LssG......................................................oPFP.ThYYLTsPthsuthS+LE..us.G.lM+cMscRL.....up..D....t..E....LAstYcpAHEsYlAcRstlt......................................................................shh.s.sh.SuGGM..Ps...............R..........VKCLHsLlAHu.......LAt...GPGlNPhGDEsls..l.........................................	0	68	127	162
+2163	PF04367	DUF502		Protein of unknown function (DUF502)	Kerrison ND	anon	COG2928	Family	Predicted to be an integral membrane protein.	20.80	20.80	21.20	21.00	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.52	0.72	-4.28	140	1039	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	869	0	414	929	1403	106.80	31	47.23	CHANGED	lllsllh...l.hllGhlspshlG+tllphhEp.llpRlPll+slYsul....Kplh-slhssppps.Fpp....sVLlcaP..pp.GhasluFlTspstsclttth............chluValPToPNPToG	..................llslhh.l.hllGhhs.p...s.h..l..G..ppll.phh-t.llpR.l.PlV+sl.Ysul....K.Q.........lscslhsspsss...F+c.................sVLlc.a.P......cp.GhasluFlTupss.sphttthtp..........-hluValPToPNPToG...........	0	128	287	356
+2164	PF04456	DUF503		Protein of unknown function (DUF503)	Waterfield DI, Finn RD	anon	COG1550	Family	Family of hypothetical bacterial proteins.	21.20	21.20	23.70	26.50	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.49	0.72	-4.39	79	654	2009-09-13 11:37:40	2003-04-07 12:59:11	7	2	651	1	239	472	24	88.80	34	91.95	CHANGED	hlus.lplclhl.ssspSLKEKRtll+slls+l+p+FNVSlAElsppDhapcutlGlusVusspspscphlppl.ch...l.-pps.-h-lhshchE	......hluhlphclhl.s.-s+SLKEKRull+slls+l+p+F.N.VSlAElspp.DlapRstIGlusVSuspspscchlsplhca...l...-uts.EhElhpsch................	0	109	193	227
+2165	PF04457	DUF504		Protein of unknown function (DUF504)	Waterfield DI, Finn RD	anon	COG1531	Family	Family of uncharacterised proteins.	22.20	22.20	22.20	22.50	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.09	0.72	-3.81	36	171	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	169	0	131	171	3	53.70	33	12.31	CHANGED	hlsYhcR..s.s......sh.pplshspltphpsthlhh........-shIPhHRIlcI..hpcGcllWcR	................lsY.DR...ht..........sh.cclshsphcptpsshh...............-phIPhHRIlhlh..+p.....cG..cllWcR....	0	40	72	106
+2166	PF04458	DUF505		Protein of unknown function (DUF505)	Waterfield DI, Finn RD	anon	COG1542	Family	Family of uncharacterised prokaryotic proteins.	28.50	28.50	28.90	101.90	25.40	28.40	hmmbuild  -o /dev/null HMM SEED	591	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.88	0.70	-6.39	5	33	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	29	0	22	36	0	543.50	33	98.34	CHANGED	MlLpKRHAElL+clKEscppsEhctKlsE-Fcpcsl.....hELEltGLs+LcGsscacLT-AG+phsphLtEhlDKhsLEc.P-pW.tp.RWlGSEIIpMl+hscLs.G+VPEcWtctLcERGLA-E.........ssLTcaGKslLElY+EoHP+LYlTsElAuaIR+MPcGPGshcphlpYKsTlshGDNIlpALEAMRLLlISPPs-sG+sYALTuLGptVcpALchsPsss+sLILcclhEDFhsh.....pcLc-uEcsscLEcuGasscGsLTchGE+lh-sYKhhGKs-ahslPsasLE.DEl+lLKsI-+LhKKaEcNP-llPThKEIcR.h.....................................................EahRsDlD.lsssL+sLES+-LIc+cls+cG....KssYhLTEaGE+VL-s.....lusVoA-GVKAIThocu.F-uPssEWlccA+-EGLV+sGAlT-KGRhYu+LS+cIKRKPaLT+aEhplLtKlP+KuhIcR-cLlEhlpDcVGuEE+cIlcALucLEAKGFV-EL.NssVpLTEAG-clKTAIcsupp.Ellcl+aPVTPssaRlLKAIYDptcpas+tcKl+tpPKsaKt.....lcKcLuLosEphKKsLsLLRplGFlGppuLTEAGlsLLcAa-	.MllpKcHh..hLpclhppcp.tchptthhEchpp.csl......ELplhGLlch...tss.tphpLTauG+thh.hLt-.....................hhcch.................lp....p.P-ta.ttaRaluSElIuMlchutcs.uc.l..st..h.hc.tLcERGhAc-..........ssLophucslh-lY+.ps+P.clhlss-lApalRcMP.GPup.......pshh.shssp.hthLEAMRLlsaSlP..pu-sauhTsLGptlppAlphh.shstc.sll.c.chh...tDh.t.......ptlp..ch..cpph.hphhhh.stpGplp.hGcthh-sY+lhpcts.hsh.saslp.pEhclLcsIcclh.c.+.h-psP-.hPT.cp.Ic+.h.....................................................pahcpsh-.lptsLasLEuFsLlcpc.pcp......+.sYhlTpaGccVl-t.t..thpslousuVKulThscp.hssPshEWhppAccEsllusutsTppG+hYtcLuhphcRhPhlT+hEhplLppl.Pp+t.h.ts.hhc...shsht-Eccl.....ALscLEA+GhlchL.sshlhhTEhGchhKcAluus.p....shthPlsPhhhRlLpAltchGshas+tpKlRh.PcshKc.....hh.Kh.uLs.-phccsl.lhR.stalGcpulsEAGlhLLcAh..............	0	11	13	18
+2167	PF04368	DUF507		Protein of unknown function (DUF507)	Kerrison ND	anon	COG2952	Family	Bacterial protein of unknown function.	23.00	23.00	25.60	25.40	22.60	21.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.17	0.71	-4.65	20	269	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	241	0	73	139	10	164.00	43	99.34	CHANGED	MRL+ht+lPYIApKIshDLhssualcl.spsl-sltpphpcILcEslpcEctL-E+s+ElLEcpp-E..h-hhplDc+phFahlK++LAs-hshhLs...........hEDRasploHpIL-tLhcpchIc.asVs-NplKNlIasuIcsalKta-cIEctVhcKIcsYK++llsGo-Ea-llacKLYEEEL+KRGhl	..........MRlKLsHIsaIupKlhhDlhpSshlEl.KsphEpLp.pIhplLEc-lhpEctLDEcs+ELLEpppDE..hE..h..MphDc+phFWhlK++LA.-hslhLs............EDRtNcLuHpIL-cLl-pDhIp.Fh.......VSENpl+..NlIapSI-sYlKh.YEclEsEVaEKIpsYKpK.lsGS-EY-LlFEKLYpEELRKKGh.....	0	28	58	71
+2168	PF04370	DUF508		Domain of unknown function (DUF508) 	Finn RD	anon	DOMO_DM06371	Family	This is a family of uncharacterised proteins from C. elegans.	25.00	25.00	33.70	33.70	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.95	0.71	-4.60	2	11	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	5	0	11	9	0	141.30	44	57.13	CHANGED	pPSthoTcsspps.spssTSuoShssuSpppSlPo....Ta.ssapphst+hVTMVpVKFlLlHpDshpRRsQShFTDEF.SDCRLE-VllNFpQLCsRQLhDtphpPRLSYCIGElshpsSKPV.usDhuKTLsQLAsopslhQhulIVD....Nhc.	.....................................psssSss..S..ouS.s...Ssh..hSlPph....Ta..u.s.ph..p.p..ou..KhVhMVaVKFlLLHhDlh+RpsQSsFsDEFsSDChLpDVlhNFpQLCsRQL+s..p..chpPRluYCIGEls.hNSKPVhppDLtKoLAQLAsopolhQFuLIsD........st..	0	1	4	11
+2170	PF01871	AMMECR1	DUF51; 	AMMECR1	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	This family consists of several AMMECR1 as well as several uncharacterised proteins. The contiguous gene deletion syndrome AMME is characterised by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1 [1]. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery [2].	25.00	25.00	28.30	28.10	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.00	0.71	-5.13	76	937	2009-09-11 09:06:12	2003-04-07 12:59:11	12	8	800	7	555	903	86	170.30	30	62.01	CHANGED	llplARpslpptLpstp...............hssthpp.ptusFVTl.cp..........ps...pLRGCIGthps..........tsLhcsltcsAlsAAhcDPRFs..Plptc.ELsp..lplEVolLos.c.ls.......h..cplc..lG+aGlllct......G.hhpGlhLPQVssEpsW-tppFLsphsh.KAGls...sssW.ppssclhpFpupl..ap....E	.......................................h.hthshpsl.thl.pttp................t.h.s.t.th......pp...ptulFVTl.cp...................ctpLRGCIGohps..........tsLt.psltchAls.u...........Ah.cDs......RFs..Plptc.E.Lsp..LphsVol.Losh.E.hs..............................................sh.tchc.....lGpaGlhlch...............................s.tpsus.hLPpV.hEp.sas.p.p.p.h.l.s.plhp.KAGht.......s....p.pshclh+apsphh.............................................	0	209	357	469
+2173	PF04459	DUF512		Protein of unknown function (DUF512)	Waterfield DI, Finn RD	anon	COG1625	Family	Family of uncharacterised prokaryotic proteins.	24.60	24.60	24.70	25.60	24.30	24.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.17	0.71	-5.25	60	441	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	416	0	174	431	193	194.80	30	44.54	CHANGED	VPVGlT+aRt..sh.tLpPlstcpAtcsIsplcphQcchppchGstFsahuDEaYllAGpslPsht.YpshPQl-NGVGhl+.Fhcchtcthpp.ls.......pppcholVTGphstphlpplhccL.sthpGlplplhsltspaaGpsloVsGLLTGpDllptLpt.....p-lG..-tlllPslML+p.......spthFLDDholc-ltpp...Lssslhllcussc	.....................................VPlGlT+aRp......tlhtLpshspcp.A..tcslpplcphQ..........cchhp.ch..GppahahuDEaY.......llA.....s.....p.lPs.phY-s.asQlENGVGhlRhhhpp.hppshpp..l.......................httppphollTGphuhthl.pphhcpl...p.....th...sl...p.lplhslpNcaFG.pslTVuGLlTGpDllppLcs..............................pplG....-tlllPssML+p.................scp..lFLDDhol.c-lppp...L.t.hplhlsp....t......................	0	71	129	159
+2174	PF04375	HemX	DUF513; 	HemX	Kerrison ND, Moxon SJ	anon	COG2959	Family	This family consists of several bacterial HemX proteins. The hemX gene is not essential for haem synthesis in B. subtilis. HemX is a polytopic membrane protein which by an unknown mechanism down-regulates the level of HemA [1].	29.30	29.30	29.50	29.30	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.09	0.70	-5.87	5	1205	2012-10-02 17:03:51	2003-04-07 12:59:11	9	3	1165	0	207	918	162	356.10	38	87.20	CHANGED	uusPp-sAcpssssSoPsAscsss+susussLAulALLlA.LGLGAGGaha............uLQQlschps+s-ALApclpQlssAp-s........spcpplpclp+ssp-thcQLc+pLushs+plsplQppVuslpuu......sssDWLLAEADaLL+LAuRKLhL-pDVsTAsuLLcoADspLAshNDPulpAlR+AlAsDIssL+AlPpVDpsGlhlRLssLpNQIDsLsLlssshc............tuspsusupAlo-ulu..............-WppNLp+Sl+uFhssFIsIRpRDsoshPLLAPsQchYLRENI+L+LpsAthAVhscQ-ElYRQAL-sAuoWlcuYFDT-sssspuFhtplDpLAcQslpV-lPspLQApssLpcllscRlpslph...ulutsAscu	........................................................................ppstpt.s..psss.p.s....s..s.s......p.t...t.......p....p....p.....s....s...u.....h.....h....L....u.....s...l.Al.s....l..A....LA.h.G...s....G..h.ah.a..............................................s.p.Q.Q.s..s.p.......s....s.......p...s.sA...L...ss...QL.s..sh.p..pupp................................sppscL..c.s.h...h...p...p....p...s..s...p...l.c...p....s..pp....p............p....s...h...s...cplscl...Q...pp.l.uslsup..................sscsWLL..ApADaLl+LAuRKLa.-pDVsTAsuLLcoADupLAch..NDPuLlslR+AIssDIusLpul..s..plDhsGllL+LspLpsQlDs..Lt...L..u.s.s.s..s.s.........................................................................tu.s...h..s..s.c....u.pp..l.S.uu..lu..........................-W...p.........N...L...p+...Sh...p...s.......F...hcsF...IsIRRR...Ds.s.s...h.PLLA.P....sQchYLRENIR.RLLsAtpAV.++QpEsY+puL-ssusWl+uYaDsc.cs.sT+uFLccl-..pL.upQsI..s.h...-.l..P.-...pL.p.S.p.shLcclhppRhpph...............stst.......................................................	0	34	94	156
+2176	PF04415	DUF515		Protein of unknown function (DUF515)    	Waterfield DI, Finn RD	anon	COG1627	Family	Family of hypothetical Archaeal proteins.	25.30	25.30	25.30	49.70	23.90	25.20	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.27	0.70	-6.23	6	64	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	39	0	46	66	5	243.40	20	93.40	CHANGED	ccpsP..................................KspPhKpPpRRss...................Rluo.+p+......................EcRpRlIIGA.VlslIIlhhshulYhahpspthpE...LENsKssKIuElNphFtu.chuNDsp.......KhthlsKIpuApslEElppIsV.t.hpp...........h-ptchhhplpphKspsIppIKstaG.lhphpl.ssELcpKI.....suplpsLhppVssscshcEllphp.-phLhsh.KhhY.............lchstcchhhoKD-AKcllsphs.ls-LhpapVpsV-hVplslVlsRpphsGulhpsGDpVplYsKss..ushh.tllspuYV.L........upIusSESpSpSoossspSSoooppS.pop.Ssu.tsph.sopp.p.p..soQotspp.SSShSYol.NLspIL+AhAAGKlst.scl+spLpsYGh+L.-lEcsTpl.thsEsTphLlIlcVPs-hVPcllphcsulllshsss	...................................................................................................................hh...lh.hhhhh...h.ha.........p.......hp..+..thttlptha....h.sp..............h..h..pl..u.s.pph.tl..............................thtth..p...h.................................................................................................................................................................................................................................................................................................................................................................s.........	0	8	18	34
+2177	PF04414	tRNA_deacylase	DUF516; 	D-aminoacyl-tRNA deacylase	Waterfield DI, Finn RD, Mistry J, Wood V	anon	COG1650	Family	Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tRNA. D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules.	21.30	21.30	22.80	22.70	16.80	16.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.46	0.70	-5.21	34	183	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	168	4	114	186	85	216.70	29	69.66	CHANGED	lptDhh-......hhtcs-hllFlSRHpussshPsLTVHssGNhs.....s.sthGGpPtpluhusPthhssllcslpchs.........s....a-lohEATHHGPothshPshFVElGSoEp-WpcpcAscslAcullcslsp.tp..................pshlGhGGsHYAP+hoclslcschslGHllsKa.hs...........p.ls.........ppllppslp+s..ssch.shlDhKulputp+pplhphhcc.hulcllpp	............................h......t......thtss-hllFhS+Hsup.s.shPsLTsHssGNhs.........p.s.hGGcstpluhusPphhpshLptlpchss........p....s.................a-lshEATH.....H.G.......Po..........t..........hs.sP..........shF..lEIGSoEcpWp..spcAucslAc....ulhcshsttt.ttt................psllGhGGsHYu.s+aoclsh....c....s.p..hs..lG..Hllscatls....................t.ls....................tclltpuhpps...........ssph..shlDhcuhputp+ptlhphlcchslplh.h.....................................................	0	27	64	89
+2180	PF04378	RsmJ	DUF519;	Ribosomal RNA small subunit methyltransferase D, RsmJ	Kerrison ND	anon	COG2961	Domain	RsmJ is the tenth to be found of the ten methyltransferases required for full methylation of 16S ribosomal RNA (rRNA). It specifically methylates m(2)G1516. A strain of E.coli lacking RsmJ due to deletion of the rsmJ(yhiQ) gene is missing the methyl group at G1516 and exhibits a cold-sensitive phenotype.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.62	0.70	-5.38	8	1570	2012-10-10 17:06:42	2003-04-07 12:59:11	8	2	1530	1	321	1377	328	241.30	46	87.23	CHANGED	-KPFhhLDTHuGsGRYDLuu-cAc+TGEacpGIuRLhpp...sslPt.LpsYLcsI+phNhuss........l+aYPGSPhlA+pLLRsQDRhlhsELHPsDhslL+spFssDtpVpVcpsDGattl+ApLPPpE.....+RGLlLIDPPaEhpc.EYpclVpAlccuhpRassulhAIWYPIKsRpplccFh+uLcsosl+KlLpIELtV+PsospcsMsuSGMllINPPWsLEsphpslLPaLpppLu.s.sGphpl-Wl.s	.....................................................................-KPFhYlDTHAGAGtYpLs....u....-cA....p+TGEahpGIu..Rl...W.pp...........sc.L.P......s...t...LpsYl.ss.l+.p.h.....N.p..usp.................LR.aYPGSP.hl.A.c.p.L.....L......R.c......Q..D.......+.......lpLs...ELHPo.......Dasl.L.......+...s...p...F...............p.......c...............D............p......+...s........p...Vp...+...t..DGapt...L...+...A...hLP...P.hp........RRGLlLIDPPYEhK.s...D.Y.pt.VVpultcuaKRF.uTGs.YAlWYPl.....l......R................p.....p...........l....c....+.....h........h.ccL.......c........s.......s.....G.I.......+.....+...lLplEL......sV.....p.......P.........c....o.........-...............p......p.........GM.s...............uSGMlVlNPPWpL.......-pph.pslLPaLpptL..s.s....sG..phplpWl.................................................................................	1	70	169	245
+2181	PF04461	DUF520		Protein of unknown function (DUF520)	Waterfield DI, Finn RD	anon	COG1666	Family	Family of uncharacterised proteins.	22.00	22.00	23.10	22.20	20.70	19.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.09	0.71	-4.37	108	2052	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	2015	2	466	1129	1083	158.50	49	98.52	CHANGED	MPSFDIVS-lDhpElcNAV-pup+ElssRaDFKGoc.usl-lpcc..plpltu-s-apLcplhDlLpsKLsKRsls.h+sl-hs.pspptoGpps+Qplpl+pGI-p-hAKKIsKhIKDsKlK.VQAuIQGDplRVTGKKRDDLQtVhsLl+.pp..-ls.....hPLQFsNaR	.......MPSFDIVSElDhpElcNAV-pAs+ElsoRFDF+Gsc.A.slELs-c.....slplhu-uDFplpQlhDILpuKLlKRsls.spuL-hs.c...p...htSGcshp.pscLKpGI-s-sAKKIsKhIKDoKlK.VQApIQGDplRVTGKpRDDLQuVhAhlR...ts.....DLs........PlQFpNFR...........	0	133	293	392
+2182	PF04412	DUF521		Protein of unknown function (DUF521)	Waterfield DI, Finn RD	anon	COG1679	Family	Family of hypothetical proteins.	27.80	27.80	27.80	35.20	26.90	27.70	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.03	0.70	-5.92	42	289	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	256	0	143	298	337	382.20	33	88.27	CHANGED	hhLocp-cshLsG-tG.puhppAMcIllthuchhGAc+LlslspAHls....Gs..........Yp..GsuuL....cFlcchhp.huu+VpV........PTTlNshuh..Dh.p.hcphs...lstphscttt...clhcAahch.......Gs..csohTCsPYh..lts.hPph.....G-plAWuESsAVlaANSVLGARTN+cus..sLsuAlsG+sPhhGlHL-ENRpuslllcVcs..t.....csu.ashLGalsGchsss..plPllpGLps........sspDcLKALGAAhAooGusuhaHltGlTPE..A.shtssh.t...............-plslsts-ltpshppl....sssspplDlVslGsPHhShpEhcp....luphLcu+c...sshslhlssuRtlhppspc.GhlptlEphGspllsDT..ChllsPl.....hstttps.lhTNSGKhApYsPuhsGhslthGolpcClcu	.........h.Locc-ct..hLsGchG.cuhphAMcIllthuchhGAp+Lls....lsp.AHls.........Gs...............Yp...GpuuL....cFhcc.l.hp...hGu+Vp....V.................PTTlNs.huh..Dh.p.hctht.....lspp....htc....ttp.......clhcAahch..........Gs..psoaTCsPYh..ht.s.hPph.....G-plAWuESsAVsaANSVlGARTN+pus.hsLsuAlsG+sPhhGhHl-ENRpuplllclps..t...........sss.ashLGahlGchsss..plPhlpGltt........ssp-pLKshGAAhAooGusshaHl.GlTPEA....shtssht........h...........cplplstp-lppshcpl.....tssspplDhlslGsPHhSlpEh....pp.....luphlc......u+p.........psslhlssuptlhttsc.p..GhhptlcptGspll..sDT..C..hls.sPl............thps..lhTNSuKhApYhPuhh.GhpshhushtpClc.....................	0	42	84	111
+2184	PF04463	DUF523		Protein of unknown function (DUF523)	Waterfield DI, Finn RD	anon	COG1683	Family	Family of uncharacterised bacterial proteins.	22.70	22.70	22.70	23.20	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.99	0.71	-4.42	164	1833	2009-09-12 22:11:40	2003-04-07 12:59:11	7	10	1453	0	463	1420	90	141.80	33	63.83	CHANGED	lhlSuCLlGppVRYc..Guppt..sph.....lpphlpcth.hls..lCPEltsGLssPR.shclh..s............ssph.+lhs.ps.u.pDlTcphhphupptlpthp....slsshIlppcSPSCGhppl..Y........psshs...stthtG.pGl.huthlhcpt.hl.sE--h	..........lhlSuCLhGt..s...sRYD......Gspph.........ssh...........lpphl.p.p...t..h.......hls...lCPEl.t.s.GLssPR.sshcllt.....................t.sps.+l.hs..ps..u..pDVT......cphhphupptLp..phpt.......plss.....h.I.lp..s+SPSCGhppl...Y.............cu.phs......s.t.ptsGsGlhsthl.hcph.hl.sE--.............................................................	0	157	291	373
+2185	PF04411	DUF524		Protein of unknown function (DUF524)	Waterfield DI, Finn RD	anon	COG1700	Domain	This domain has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches [1].  The domain has two additional beta-strands inserted to the core fold after the first core alpha-helix.\	      It has been speculated that it could function as s methylation-dependent restriction [1].	22.10	22.10	22.40	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.17	0.71	-4.39	28	222	2012-10-11 20:44:43	2003-04-07 12:59:11	7	5	207	0	64	224	13	157.30	25	23.37	CHANGED	pLYEhWCalplhplLpph.....Ghphtppslhpspspsh.thslppsps....hhh..p..sshplpLtYpspht.t...........t..shsp+PDhsLplshtstt......hhhlhDAKYRl-sspct............................p-slspMHpYRD...Al..............ppsshuAalLaPGtps	..................................................pLYEhWsalplhplLpph.....................thph.hpp..s.l.h.p...hp.p.psh....hsslp.cups......hhhh.....p...psstplpLhaptph....t...............................t..sssp+PDhhLplpppspph................hphlaDAKY.Rlphs.tpt...............s.....................pcslppMH....p..YRD....Alh......................tt..hp+sshuualLaPhp.c...............................................	0	28	46	57
+2186	PF04379	DUF525		Protein of unknown function (DUF525)	Kerrison ND	anon	COG2967	Family	Members of this family include the bacterial protein ApaG and the C termini of some F-box proteins (Pfam:PF00646).  F-box proteins contain a carboxyl-terminal domain that interacts with protein substrates [1], so this family may be involved in protein-protein interaction.  The function of ApaG proteins is unknown, but mutations in the Salmonella typhimurium ApaG homologue corD gives a phenotype of low-level cobalt resistance and decreased magnesium efflux by effects on the CorA magnesium transport system [2].	19.30	19.30	19.60	23.30	18.80	18.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-9.91	0.72	-4.02	147	1678	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	1515	9	519	1070	541	89.30	48	52.06	CHANGED	l........s-pSsPpps+..asFuYslsIp........Npupp.s.....sQLl........oR+WhIT.DusG.chpEVcGpGVVGcQPhlpPG-.sapYoSGssLsTPsGsMpGpYpMhs...cs	..........................................................l..tQSsP-.p.p+..YsFAYslTIc..............NhGpt...s...........VQLl........uRaWlIT.....sus.........G....+.p..EV......p...G.cGV.VGpQPlls.........PG-..p....apYTSGss....lp........T.......P.......h.G.s.MpGpYpMlsc.s....................	0	150	289	406
+2187	PF04380	BMFP	DUF526;	Membrane fusogenic activity	Kerrison ND	anon	COG2960	Family	BMFP consists of two structural domains, a coiled-coil C-terminal domain via which the protein self-associates as a trimer, and an N-terminal domain disordered at neutral pH but adopting an amphipathic alpha-helical structure in the presence of phospholipid vesicles, high ionic strength, acidic pH or SDS. BMFP interacts with phospholipid vesicles though the predicted amphipathic alpha-helix induced in the N-terminal half of the protein and promotes aggregation and fusion of vesicles in vitro.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.77	0.72	-3.84	131	1484	2009-10-26 17:57:44	2003-04-07 12:59:11	8	3	1473	0	318	838	803	78.10	44	82.37	CHANGED	M.ss.chl-.......-lucphspshsss...puhtc-...lEpph+shlppths+lDLVoREEFDsQpplLt+sRp..........+lcsLEsRlutLEsp	....................Mhss.+hl-.......plA+plp-uhstu...hpphucD...lEcplR.p.hLQutLs+..LDLVoREEFDVQspVLlRTRp.......KLst.LEpRlucLEst..............	0	79	171	241
+2188	PF04384	Fe-S_assembly	DUF528;	Iron-sulphur cluster assembly	Kerrison ND, Eberhardt R	anon	COG2975	Family	This family of proteins is likely to be involved in the assembly of iron-sulphur clusters. It may function as an adaptor protein. In Escherichia coli Swiss:P0C0L9 forms part of the isc operon, which encodes genes involved in iron-sulphur cluster assembly. Its structure is entirely alpha helical, and it contains a modified wing-helix structure, usually found in DNA-binding proteins. It binds to Fe2+ and Fe3+ ions and to the cysteine desulfurase IscS, the same surface of the protein is involved in both binding to iron and to IscS [1,2].	25.00	25.00	26.00	25.40	20.60	18.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.90	0.72	-3.61	61	1135	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1120	2	184	434	221	63.60	63	95.87	CHANGED	hKWsDsp-IAhtLh-paP-.lDPts...lRFTDL+pWVhsL...ssF-DDPp+ssEKILEAIQhsWl-Eh-	................lKWTDoR-IuEsLYDtaPD..lDPKT...VRFTDLHpWIs-L...-DFDDDPptS.NEKILEAIl.hsWlDEuE..................	0	40	86	134
+2189	PF04385	FAINT	DUF529; 	Domain of unknown function, DUF529	Mifsud W, Yeats C	anon	Yeats C	Family	This family represents a repeated region found in several Theileria parva proteins. The repeat is normally about 70 residues long and contains a conserved aromatic  residue in the middle. 	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.31	0.72	-4.13	64	1072	2009-09-11 15:51:37	2003-04-07 12:59:11	10	26	6	0	961	1070	0	76.20	15	28.74	CHANGED	hlcl.....tshppsphhhhp............hhhhhhthp.pshphpplhh...........psphlWptpsspphhhhhhhhhptt......hhlhlhhsptt	....................................................pp...ht.............ttthhpaph+.suhphpKlhh.......................ssp.hlWcp.sc...s.sp.hs.hh.h.h.ht..........hhhh.......h.............................	1	2	558	558
+2190	PF04409	DUF530		Protein of unknown function (DUF530)	Waterfield DI, Finn RD	anon	COG1771	Family	Family of hypothetical archaeal proteins.	20.10	20.10	20.30	104.10	19.00	19.80	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.58	0.70	-6.40	7	60	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	39	0	47	64	5	306.90	25	99.99	CHANGED	.ooptLIspsN+hLDsIs.c..hschhcDhDshh............lhhTLcsNLc.Lp-LcEchEhR.G.tuPh.sltch+utts................HhpalhRKtp.+phhLERl+SAIsuHKIALuhLpt.h.hph.pst.p.p..p.p......................chch..p..slGRlEIlPaLshuG-hhclhuphs..shcuaKcIhshh+pEGhsthcShplplchhEp..G+..hK+h+l-.s.DsDhEt.LRK+aGpphRhcllphh+o+ssLINs+YshcsLALAYhshs......................................................................ccGtcL..........................luhDlF+YYhhTS.c-Rpp.ss.FPul+sslDspa....ol.sls.+chhDhh.s.hp...........hl.hKh-lEcpLsKh+hcls.h...hlGGlhLYhhusas.pcss-lhtl-lEElhc..hhhhlpslhpllhsc..-hpKhEKa.hP+o-KAKpFLpLLpG	............................................................ppp.Lltp.pchLptlt...........t.hp.p.................................l...Lppplp.Lpphcpphph..t...P...h.phttt..................a.phhhhhhp.+h..L-Rl+.AlsuH+hAlu.ltt..................................................t.hphpl...LshsGshh.hh.p.s..hhpta+.hhthhp.pt..................hs.hpthph.l.hhpt..s+..h++.pl-.....shEt.l+ppaGpth.hp.hph.hphs.llsspYshp.LuluY..h............................................................................................................h..DlhhaYhhpo.pcRtt..s.aP.lh.s.p.t.......h.th...t..th.....................Kh.hEp.h.thp..hp......hGuh.l......hp..p..th.th..ppl.c....................htphpph.h.ppt+s+pFLthl..t......	1	6	11	31
+2191	PF04407	DUF531		Protein of unknown function (DUF531)	Waterfield DI, Finn RD	anon	COG1772	Family	Family of hypothetical archaeal proteins.	25.00	25.00	80.50	79.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.87	0.71	-4.38	9	38	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	38	0	33	41	9	170.90	53	89.30	CHANGED	MLTlGLYNTYDpp+lHEAHhRAIARAAPlsYAFsF+LALhsFPac...h.sscElsEhVscpTTIG-uG+YLhtLt-pN+halhDhPp+GFPsQFGplVuTTSKP-ccKslsPh-lAchhL+s+ShhllIGLGR+GLPKElachucYHLDIT.s+tlSLETCTAIGuIsAhIhslhcsh	..MlTLuLYNTYD+pKlHEAHhRAIARAAPICYAFsFpLALhsFPhc.........t.p..-ls-hls.pcTTIG-uGcYLtcLh-pN+FallDhP.hGFPsQF.GpsVATTSKP-ccKtIoPh-lAchhL+t+ShhlLlGLGRHGLPK-lhKhu+YHLDIT.GKslSLETCTAIGuIPApItTlhc.h....	0	6	12	24
+2192	PF04391	DUF533		Protein of unknown function (DUF533)	Kerrison ND	anon	COG2979	Family	Some family members may be secreted or integral membrane proteins.	29.60	29.60	29.80	30.40	29.20	28.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.09	0.71	-4.92	61	974	2012-10-03 21:00:09	2003-04-07 12:59:11	7	5	942	0	139	548	37	188.60	44	85.52	CHANGED	uuhlss........husG............uLs.....GGlhGhLlGs+pup....phuusuhthGGh.AulGsLAYpAYpsa..psp...ps...........sssssspshstsss...................tt-pputhlL+AMIuAAKADG+IDppE+ptI.tplschshDsctppalpppLppPlDsstlApts.ps.phAsElYhAShlsl-.-shtE+uYLspLAptLsLssslspplEppls	...................................................................................................ts.sth......LssG.......AL..GGLAGlLlusKouR..........KhGssA..LhlG.Gu.As...h.Gslhap........tYpch.......p...s.................................stQspPQhsspsss.....................................................h-p+oppLlhAhlh............AAKSDGHIDscERA...tI-...ppLcEu..Gl...-...cpucshlEptlc....pPLDPp.cL.Apul.psEEpAh.......ElYhhS.phAID.....D.........pFM...ERuY....LstLucAL+lspslp-tIEpsl.p......................	0	31	61	102
+2193	PF04392	ABC_sub_bind	DUF534; 	ABC transporter substrate binding protein	Kerrison ND, Mistry J	anon	COG2984	Family	This family contains many hypothetical proteins and some ABC transporter substrate binding proteins.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.49	0.70	-5.46	9	2266	2012-10-02 13:57:41	2003-04-07 12:59:11	7	34	1502	3	510	1839	143	277.50	32	82.31	CHANGED	cIulhthlpHsuLstthpGhp-uLp-hGhpp.p..hhphhNApss.spstphu+pLhscpsclllsIuTPsAQtlhuthcs..lPlVhuAVosPlutpLs.shcpsttNlTGVs..Dt.slppplphh+tlhPss+slslhYsPuEssshshhccl+thAcptGlpVlphslssos-lspshpshsp+ssulahshsshlssuhsu..llpsupptKIPlhsussuhVccGuh.AAhulshpphGhpsuphlhclLcGpcst-lssphssp....phhlNcpshppLGIplscshhspusphc	.......................................................................................................................................................................................................plulhphlpHsu..LDth.hcGh.....-sL.tct...Gapp...c..plc.l.......c....h....p..N.A..p.....G.....-....p......u......p....htp.hu.....p.p..h..s.s.p....p..s.D..ll.l.u.I...A..TP..u...A.Q......u..l.........s.........s...s........o.......p........s.............l....P.l..lhsA.V.T.D.P.....lu....A......tL...V.p...s...h.....c.p.P....G...s....N.lTG..sS.......D..t..s..P...lp.pp.lcL...l.+c.lh..P.s.s...K.....p...lGl..l...Y..s...s.u..E......s..N..S...h..s..pl..c.p.h.+..p...h...s...p..c..t..G..l..p...l..h.......p....h........s........l.......s..........s..........o.........s.......-.......l....t........p........s.......s.........p........s............h....s...s...c........l.....D.....s...l....a.....l.....P......s...D.N....s.........l...s...S.....u.....hps.........l..sp...s..u.......p...p.....s..Kl.......Pl.h.s......u..s.s.s.h.....V...c...p.G...u...l...A.u..h..u.l..s..h.h.p.l.G.hp...T.Gc.h.ss.c.l.....L.c.G.c.c.P.u.s.h.sl.phh.pp.....chhlNpch.AppLG..lslspthhtt.....h....................................................................	0	178	346	426
+2194	PF04393	DUF535		Protein of unknown function (DUF535)	Kerrison ND	anon	COG2990	Family	Family member Shigella flexneri VirK (Swiss:Q99QA5) is a virulence protein required for the expression, or correct membrane localisation of IcsA  (VirG) on the bacterial cell surface [1], [2]. This family also includes Pasteurella haemolytica lapB (Swiss:P32181),  which is thought to be membrane-associated.	19.10	19.10	19.10	21.40	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.84	0.70	-5.50	34	1261	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	911	0	96	664	6	271.70	36	90.85	CHANGED	hhstps.....hhpphpp+hKahhRsllhhtphpphhphlsp...shhpslhpppPphst+lh+PYlspshstppRlpsltpHaphhppthstphhp.lhppt.slpLsplp...tppaslhLshssths+EG-hsL.Lpspp.tphlhploFolh.........sppsLhIGulQGsss....-psp-hl+phTKshHGLRPKpLllEshphLApthslcplluVupcsHlapph+a......ppclhsDYDphWpEhGGp..spsaap.LPlphtRKsl--IsSKKRuhYR+RYthLDplppslpptL	..............................................................t........thhpctpaRh+FhlRsll.hsthsh.phhptLsp...PphpsLls.p.p.Pplsh+lpRPYls.........tshs.tpp+lculh.Hathlpp............h............hs...........t..c..h............p.....hls..p...slpLuc.........lp.sK.......ss-pa..sl..pLs.h.hshc.+EG-holhlp..ssc....tsLuploFol..s...h.p......sppshhIGGLQGsph......chspphIppATKsCHGLhPKcLlhEAhphhApthpl-pll.AV.opcsHlapphRY.h.pK..cpph.hAsYssFWpslGG.....p...p......t.p...aac..LPhp.lsRKslt-IsSKKRupYR+RYthLDslptphst......................	0	11	32	65
+2195	PF04394	DUF536		Protein of unknown function, DUF536	Mifsud W	anon	Pfam-B_2107 (release 7.3)	Family	This family aligns the C-terminal region from several bacterial proteins of unknown function that may be involved in a theta-type replication mechanism.	20.70	20.70	21.60	21.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.53	0.72	-4.22	29	746	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	588	0	44	358	4	47.70	44	25.93	CHANGED	hccQlppcc...........pplpch.......ppLLDQQQpLsLpspchlEc........hKs	..............................hccQlchKD...........pQIsEt..............sK.LDQQQpLsLpuhKchEpLc.pL-p.t+.......................	0	6	14	32
+2196	PF04398	DUF538		Protein of unknown function, DUF538	Mifsud W	anon	Pfam-B_2637 (release 7.3)	Family	This family consists of several plant proteins of unknown function.	25.00	25.00	25.00	25.10	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.22	0.72	-3.80	58	600	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	46	1	341	552	1	111.40	29	68.11	CHANGED	osh-lLcpashPhGLLPpsl.p.sYshspsoGphp.lhhs......s.........s..Cphphps....hp..lpY.........ssplo...........................GhlspG................+lsslpGlpsK.......lhlWlslsclth....susplhFps..Gshs....cshshssFpps	.........................h-lLpchGLPtGLL.Phss..p.pashscsoGhhh.lhhp.....p..........s.Cphpacs....ht..lpY.........ssplo...........................GhlppG................+lpplpGlcsKt......lhlW.lslspltl......susplhFps..usls....csashssFp.........................................	0	30	189	274
+2197	PF04400	DUF539		Protein of unknown function (DUF539)	Kerrison ND	anon	COG2991	Family	Putative periplasmic protein.	20.80	20.80	21.00	20.80	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.62	0.72	-4.47	37	588	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	495	0	111	320	178	45.40	45	59.21	CHANGED	hIhp+KsIpGSCGGluulGl-KtCD.C...cpsCDpppc+.hpttt..tp	...aIhp+KslpGSCGGLu.u.l....G.l.-K.sCs..C.............scPC.Dscp++hspttt...p.........................	0	25	53	87
+2198	PF01877	RNA_binding	DUF54;	RNA binding	Enright A, Ouzounis C, Bateman A, Eberhardt R	anon	Enright A	Family	PH1010 Swiss:O58738 is composed of five alpha-helices (1-5) and eight beta-strands (1-8) with the following topology: beta-1, alpha-1, beta-2, beta-3, alpha-2, alpha-3, beta-4, beta-5, alpha-4, beta-6, alpha-5, beta-7, beta-8. The first six beta-strands (1-6) form a slightly twisted antiparallel beta-sheet and face five alpha-helices on one side. The last two beta-strands form an antiparallel beta-sheet in the C-terminus. PH1010 forms a characteristic homodimer structure in the crystal.\	      Dimerisation of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5 [1]. Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family [2]. Despite this, these proteins bind to double-stranded RNA in a non-sequence specific manner [3].	22.90	22.90	23.60	27.50	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.43	0.71	-4.10	52	277	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	140	17	189	274	118	115.90	25	77.86	CHANGED	pplplpshlasTEDp-KVhcAlpslh............chphphpptcGaaup.....p.hlptt.sspcsLcplpchlcppcl..cth+s.tlpcplp..ssphhh+lsKQsAa.hGplphsp.ss.....ssIplplchc	..........plplpshlasTED.cKVhcAlpslh............shchp.h.ppppGaas.......h.lptt..pspcslcpltchlcppcl..cthps..lpcplp..ssplhh+lcKQsAa.hGplshsc.ss......ssIplplch............................	0	47	104	149
+2200	PF04402	SIMPL	DUF541; 	Protein of unknown function (DUF541)	Kerrison ND	anon	COG2968	Family	Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries.  However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase).  SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity [1]. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerisation. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics [2]. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	24.90	24.90	25.30	25.30	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.12	0.70	-11.52	0.70	-4.47	156	2985	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	2441	0	788	2172	443	200.80	20	84.19	CHANGED	lsVsGpuphpstPDhstlslslps..pspssspA.......hpp.s..spphppllstl......p...phu.......lt...p...ps.lp.....s......sshsl.p.............Ppa......p...........................................thtG.Y..........psspp.lp..lphp.cl....sphup......llsthhs...tsh................s..pl....sslpaplsctpphp..pcshppAlpsA+p+ApthApsh....G.hplsplhpl...............p.sstss.................hhthth.ttss..........sshpsuphplsssV.....sssapl	....................................................................................lslsGpuphc...sssDhsplslplps...........pupsss.su.............tpp.s.....spphsphlshL....c......................ptG....................................ls......c...c-........lp.........s...ushsh..p................................PpY..........pa.p.....................................tpptlpG..Y.......................................pusps..lp..lphc...sl.......splsp..............ll...st...hhp........tGh..............................................s...pl......psl..p..a..s..l..sp.....sthc..scshppAlpsApppApplApuh.....s..tpLG.t.l.h.pl.........phustss...............................ht.h..th.ht......................sh.p.sphphpsplsssat.............................................................	1	250	495	659
+2201	PF04418	DUF543		Domain of unknown function (DUF543)	Bateman A, Wood V	anon	Wood V	Domain	This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long.  However the Arabidopsis homologue is over 300 residues long.  The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.	21.30	21.30	23.20	22.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.67	0.72	-4.02	35	301	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	235	0	198	280	0	72.70	36	72.16	CHANGED	Moppsp.......................................plscKWDpslussllKsuhGhusGllsSlLhF+R...RsaPlhhGsGhGlGhuYs-scthFp	.......................................................................scs...........................lscKWD+ClushllKsuhGhuhGllhSllhF+R......................RsaPl....hlGsGhGlGhAYspCptpFp........	0	66	107	168
+2202	PF04424	DUF544		Protein of unknown function (DUF544)     	Kerrison ND	anon	DOMO:DM04041;	Family	Eukaryotic protein of unknown function.	20.80	20.80	23.00	21.90	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.61	0.71	-4.30	8	377	2012-10-02 14:22:40	2003-04-07 12:59:11	8	9	242	0	265	379	5	124.40	30	22.46	CHANGED	sNlLlLpssls........LssppphlTt--LhphLsDhhlp.ts...........shppNhs-shslLs+LtsGLsVNl+Fs...............ulpsFEaTPEhuIFcLlslsLYHGWllDPp.s-.hsculushSYspLhctlsss	.............................................................................hNhLhLp.php........................L.s....p...tp..lohppLhphlu.....-hl..lphpst...................................sh.p..tsls-hhslLspLpTGL.sVNs+Fs............................GhtsF......E...h....T..s........E...htl.FcLhsIPLhHGWllDPps..sp....hh....pt.l..s..p..h..SYsph.phl.................................	0	79	132	200
+2203	PF04440	Dysbindin	DUF546; 	Dysbindin (Dystrobrevin binding protein 1)	Finn RD, Moxon SJ	anon	Pfam-B_3919 (release 7.5)	Family	Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localises with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane [1]. Genetic variation in the  human dysbindin gene is also thought to be associated with Schizophrenia [2].	25.00	25.00	30.50	25.70	20.90	17.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.03	0.71	-4.45	7	190	2009-09-10 17:06:14	2003-04-07 12:59:11	11	2	41	0	87	168	0	142.30	37	66.55	CHANGED	tths....csscsPpstl..ssplplptcpth..ts.ptEtEhsls...suhLplsE.+RpPluSlSShEVphDLLD.sELhDMSDQEhA-VFhsS--E.stspSPs................s.p...h.+husLcSsShsp.opsppspEcps.sDs-......ss..t.....l-	................................s...ctpcs.chth....sQQh+L+ERQKaFE-shQt-hE.hls...suaLQls-.RR..p.............PlGShSS..MEVNVDhLEQh-LhDhSDQEuhDVFLsSs..sEps.ss.SPs........................s.t.....hs.p....s..s.pSssh.s...psops..p.tttp.p..........................t...............................................................	0	3	10	37
+2204	PF04445	SAM_MT	DUF548;	Putative SAM-dependent methyltransferase	Kerrison ND	anon	DOMO:DM04150;	Family	This is a family of putative SAM-dependent methyltransferases.	26.00	26.00	26.10	26.00	25.80	25.50	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.55	0.70	-5.21	7	1454	2012-10-10 17:06:42	2003-04-07 12:59:11	8	3	1428	5	251	988	353	223.20	46	88.57	CHANGED	tclhtltstasLtpsp-sshALlhscp.....pLELRplDEsp.GulhVDFVuGAhAHRRKFGGG+GEslAKAVGlpsuhhPsVlDATAGLGRDAFVLASlGCcVphlERHPlVAsLLpDGLpRAhtDs-IGthlpp+lpLlhssuhstLp......shspPDVVYLDPMYPH...+pKSALVKKEMRlFppLVGsDhDAcsLLcsAhpLApKRVVVKRPcYA.hLusppPsauhpTKspRFDIYhst	......................................................................tt...........l...t..st.p.s...h.sLl.hs.p.....pLpLpp..h...s-s.c..G.slhVDFlsG.uhuH.R.R.K..F..G.G.G+.G..-.slAKA.lGlct.s...h..h....P..sVlDATAGLGRDAFV..L..A.S...l....G..........C....+..Vph..l..ERs.PVVAAL.L-DGLp...........R.........u....h.....t....D.......s......E.I.......s.......s....h.....l.....t.....cRl.p.Llau.sSlsh.Ls..................sh.s.sp.P-VVYL.DPM..F..PH.......+...p.K.S.AL...VK...KEMR...lFpsL.......V............G................s........D..h..D...A...D...s..LLps.A.h....tl.A..p..K......RVVVK.RP.chAs.L...u....s.h.......ts.s.sl..s..K.spR..FDlYh.p.......................................................	0	81	135	196
+2205	PF04446	Thg1	DUF549; 	tRNAHis guanylyltransferase	Anantharaman V	anon	Manual	Domain	The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His [1]. The catalytic domain Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases,  diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system [2]. Thg1 possesses an active site with three  acidic residues that chelate Mg++ cations [2]. Thg1 catalyzes  polymerization similar to the 5'-3' polymerases [2][3].	26.60	26.60	32.90	26.60	24.40	23.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-11.01	0.71	-4.54	100	440	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	356	8	291	450	19	126.10	39	45.52	CHANGED	+hchl.+paEppsp...llPssalVlRlDG+uF++Focp.apFpKP...pDt+slplMspsApsl.hpphs.clsluYupSDEhShlhcc..sssh..............asRRtpKlsShlsShhoupashhatphh.p........h................................s..PsFDuRslhhP	......................................h.hcYV.+p.FEtts.p...llspsalVlRlDG+sF+.+.....Focp.apFpKP...N.Dp+uLpLM.spsApsl.hpc...........ht....-....lslAYGpSDEa...SFla+c...pssh.............................................apRR...s..sKlhohlsShFousYshhWtpaF.p............p..L.h................................................s..PsFDuRsVhYP................................................	0	100	174	238
+2206	PF01878	EVE	DUF55;	EVE domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	This domain was formerly known as DUF55.  Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding [3].	21.10	20.60	21.10	20.60	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.06	0.71	-4.17	140	1582	2012-10-02 17:37:24	2003-04-07 12:59:11	13	19	1431	13	568	1316	1573	137.80	30	64.70	CHANGED	sY...WLhK......oEPp..........auhpph...ppptp..shWcGVRNapARN..hh+.pMchGDhshFYHSs.....tpt...ulsGlscV.s..cpsasDsoth.......s.t..........ps+WhhV-lchh.pphspslsLppl.....+........tp..t............Lpch.sll+pu..R............LSlhPVspccaphIh.ph	..............................................taWLhKoEPtt..............auhpp.....ttptt..t.WsGlR..N...ap..ARN.......hh+.pMchGDtshFYHSs........................ct.......ul.lGlsc..V.s..ppsasDsst..........stt...............tspahh..V-Vpah..cph.s..p.slsL.spl+.....................tp..sp.............................L.psh..llpps..R...........LSltPVop.spaphIhp.....................................................	0	170	336	459
+2207	PF04447	DUF550		Protein of unknown function (DUF550)	Kerrison ND	anon	DOMO:DM04177;	Family	This family is found in a range of Proteobacteria and a few P-22 dsDNA virus particles. The function is currently not known.	21.40	21.40	21.40	21.40	20.90	21.00	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.38	0.72	-4.40	10	150	2012-10-01 21:36:44	2003-04-07 12:59:11	7	3	138	0	8	97	13	98.30	67	44.14	CHANGED	phhc+HA-WS-+TFG.slpssGsLcHLuKEhlEltAsPsDlsEWADlhhLhaDutpRuGlosppIscAlhsKhslNcuRpWP-.+su-PchtI+cpsssss	.....................................IR+EHAcWSDuTFG...sVGPIGPLKHLSKEALEAAAE..P...DDL....S....E..WADMQFLLWDAQRRAGIS.DupITsAMc-KLcINhcRQWPE.PKDGEPRLHIKE.sss.PV.........................	1	3	5	7
+2208	PF04448	DUF551		Protein of unknown function (DUF551)   	Kerrison ND	anon	DOMO:DM04177;	Family	This family represents the carboxy terminus of a protein of unknown  function, found in dsDNA viruses with no RNA stage, including  bacteriophages lambda and P22, and also in some Escherichia coli prophages.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.78	0.72	-3.22	26	815	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	445	0	22	522	9	66.40	34	34.52	CHANGED	GWISCoERhP-..psp....VLlh..........t...hssthtsthhshhhssspa...............................thppsTHWMPLPcPPp	....................................................................................................................................................GWISCSERMP-.........psp.......tVLlh.................tt...hshhhss....t.h......h.s.ss.t..ss.s.ph...............................sth.ppsTHWM...PLPEPPQ............................................	0	2	7	11
+2209	PF04472	DUF552		Protein of unknown function (DUF552)	Waterfield DI, Finn RD	anon	COG1799	Family	Family of uncharacterised proteins.	21.10	21.10	23.20	22.60	20.60	18.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.02	0.72	-4.06	120	2218	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	2038	2	449	1368	357	73.10	35	43.08	CHANGED	lhlhcPpsa.s-spp.ls...cplcst.psVllNlpphcpcp...ApR.llDFluGssaulsGclp+l...upp.lalloPssVcls	.................lslhcP+sY..s...-App.Iu...-p.L+ss.csV.llNl.p.phccsp.........A+R.llDFluGssaulsGslp+V......usp..lFLhoPsNVcl............	0	149	312	401
+2210	PF04473	DUF553		Transglutaminase-like domain	Waterfield DI, Finn RD, Bateman A	anon	COG1800	Domain	This family of uncharacterised archaeal proteins are related to Transglutaminase-like domains. This family has previously been called DUF553 and UPF0252.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.11	0.71	-4.95	14	69	2012-10-10 12:56:15	2003-04-07 12:59:11	7	5	50	0	45	689	23	149.60	21	35.45	CHANGED	pclpsluppL....pGsspt-ohWNlLcW.ccNlcYDasKuphh....................................................................................h..Ip.............................................oPpEhlth+cGlCsDYAlLTuulLLs.NhsshYllphphpps..h.....HAAsAlplsGshalLDQ+.P.hchssYl........phhc.cshhIpslshY	.............................................................................................................................................................................h...t..t..s...pthhplh.pW.p..pslp..Y...shp+sp............................................................................................................................................................................................................................................hp...........................................................sP.h-sl.phppGlCpDYAlLTuul..Llp.................sh..s.......s..hY..l..........l...t...h...p.....h...p....s.p....t..........Hsssul..p.l.s..u....phal.lD..pp..s.h.....htpah.......................................................................	0	12	22	33
+2211	PF04474	DUF554		Protein of unknown function (DUF554)	Waterfield DI, Finn RD	anon	COG1811	Family	Family of uncharacterised prokaryotic proteins.  Multiple predicted transmembrane regions suggest that the region is membrane associated. 	21.00	21.00	22.20	22.10	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.24	0.70	-5.20	64	1327	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1217	0	230	848	239	223.00	39	97.03	CHANGED	hhGollNshullhGullGhhltpplP-+h+pslhpulGLsslhlGlphshps............cshlllllSLllGullGEhlplEctlsplGphlc...............................................................pst.psphscGFVouoLLFClGuMuIlGulpsGLsGDhslLhsKolLDGhoullhAuohGlGVhhSAlPlhlhQGulsLhAshlpshlsssh..........ls-hoAsGGlLIluIGlslL....tl..+cl+VuNhLPALllshhlshlh	..............h.lGshlNusAlllGullGsLlsp+lP........ERh+sohhphhGLsslslGI.hslcs...................tNh.shlluhllGulIGEhhtLEctlsphssthp........p.......+..............................................................................tp.p.s..tcpsFhpuaVshhlLFCsuuhGIhGAhppGhoGDsoILhsKShLDhFoAhIFAsoLGluVsh.ulP.lllhQhsl.s.hhAshI.h.s.lhos.sh..........hs-hoAlGGlLllAsGLp.lh......uI.......K.hh.VsNhLPALllshslshh...................	0	97	162	198
+2212	PF04475	DUF555		Protein of unknown function (DUF555)	Waterfield DI	anon	COG1885	Family	Family of uncharacterised, hypothetical archaeal proteins. 	25.00	25.00	41.50	41.20	22.30	21.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.27	0.72	-4.01	14	106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	80	0	72	99	1	102.40	53	80.82	CHANGED	ssYhVsLEAAWlV+DVcolDDAIulAISEAGK+LN..sL-aV-l-lGhphCPtCGE.h-ushlVAsTALVGLlLpMKVFNAEStEHAtRIAKuhIG+AL+cVP	....sYhVslEAAalV+DV-osDDAIslAlScsGKtLN..cL-YVEl-lGhotCPtCGE.h-sAFlsAcTALVGLhL-M+VFNAESpEHApRIAKupIGpAL+clP.	0	10	44	62
+2213	PF04476	DUF556		Protein of unknown function (DUF556)	Waterfield DI, Finn RD	anon	COG1891	Family	Family of uncharacterised, hypothetical prokaryotic proteins.	21.20	21.20	21.20	22.00	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.55	0.70	-5.14	4	172	2012-10-03 05:58:16	2003-04-07 12:59:11	8	5	145	0	104	180	67	193.90	35	90.49	CHANGED	MlLLlSPhsVEEAlEAIcGG..ADIlDVKNPsEGSLGANFPWVIRcIREhsPcD.h.VSATlGDVPYKPGTlSLAAlGAsVSGADYIKVGLYGs+Nh-pAlElM+sVVRAVKDhcsstlVVAAGYADAaRlGuVpPLtlPclAAcuGADlAMLDTAIKDGpoLFDahshEhltpFVchA+spGLhsALAGSlsppHltsL+ElGsDIVGVRGAsCcGGDRNsGRIcR-LVtcL+Ehhc	................................................LLhSstshpEAh.shtuu..sDIlDlKpPtcGuLG....A.............s.sl.+.tl....ht...h...s..st......p.....h....lSAslGD.h.s.hc..P..ss.hs..Ashs........ss.s..s.G.....scYlKlGlh..shts.tts..hphh..tth..t.h..........hh.l........lsshauD.h..........s.h.l.........thhtpuG.h...sssMlDTuhKc.G.ps....Lh-ahs.ptLtpFlp.s+phGLhsuLAGSlpht-lshLt..t..lssDhlGhRGAlCtstcRst.tlp.phVtthht..........................	0	29	70	91
+2215	PF04452	Methyltrans_RNA	DUF558; 	RNA methyltransferase	Kerrison ND, Basturea G, Mistry J	anon	DOMO:DM04256;	Family	RNA methyltransferases modify nucleotides during ribosomal RNA maturation in a site-specific manner.  The Escherichia coli member is specific for U1498 methylation [1][2].	21.00	21.00	21.10	23.80	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.30	0.70	-5.23	96	4583	2012-10-01 22:53:19	2003-04-07 12:59:11	9	6	4226	22	1026	3326	2801	217.90	29	90.03	CHANGED	ltlss.cps+HlhpVhRlp.G-plhlhs.sputtahupltphsccph..hplh........cthphssc.s.......lsls.ulsKs.c+h-hhlpKusELGssplhPhhscRo..p....pphtp+hpRhpplshpAsEQutRshlPplp.sh.shpphl.pphspt.h........llhapctt.t.tth.thttth................plhlllGPEGGaospElphhpp.tGhpslsLGsR.ILRsETAulsAluhlph	....................................................h..lss.-pspHlhpVhRhpsG.-plhLh........s.....s............s......s.......t........ha.h..up...l..t..p.h..s....c..c....p...l.....lc.lh...........................................cth..p.ts.tc...Php..................lplspuls+u.-+hEhhlQKusEL.Glsplhsl.ucRsh....s....+h......pt....c......+............htK+hp+.ap+I.shtAsEQ.st....Rsh.lPpl..p......hh...shp...p...hh....tp....hs.pt.t......................llha.t.c.s.t.p..p...t.p.hst..hp.....................................................plhlllGPEGGh.o.s.pEl.phh.........p.......p....t.......s.....h.pslsL.G.PR.lL.RoETAslsAluslp.........................................	0	362	687	881
+2216	PF04480	DUF559		Protein of unknown function (DUF559)	Kerrison ND	anon	DOMO:DM04310;	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.45	0.72	-4.40	8	1749	2012-10-11 20:44:43	2003-04-07 12:59:11	7	59	1173	3	463	1520	202	98.00	26	32.61	CHANGED	pchptpARcLRpstThsE+sLWphLRs+RLsGaKFRRQtPlGsYIVDFsCtpsKLIVELDGuQHstp..csYDApRTpaLputGasVLRFhN-EVhps.-sVL-pILptLp	......................................................................................t...................p..hh....h.....tt.....................h.php..p..ph..l........s.....t........a.....h...l.......D...h..h.....h............p....t....+......l....l..l....ElD.....G..s.....p....H...t...ps.............ht.....h...D.....t.....pR.......ss.hL....p..s..t..G..a.p.Vl.Rh.hs.pcl..h..pp..c.tVlptlht...h.......................	0	130	318	395
+2217	PF04575	DUF560		Protein of unknown function (DUF560)	Waterfield DI, Finn RD	anon	Pfam-B_4010 (release 7.5)	Family	Family of hypothetical bacterial proteins. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.80	0.70	-5.18	22	575	2012-10-03 17:14:36	2003-04-07 12:59:11	8	16	290	0	79	541	30	264.50	25	62.17	CHANGED	WpassuhsYhp-cNlNsuscptph..........ttsh..stPpsApGlsaphuhpKcasltssaahphphsstG+hYWcN+c..Ys-hosRhthGhuYpsu+pplslhPFhEppaa...........utcpYspst......GlplphshhlospWphusshEhtpppY..hcc...pchsGshphhSsoLhah.ssppaaahGhDahcpps.ps......cspSapppulRhGWuQ-Wsh..GlooplshuhupRpYcshshhh.............shpR+DcpassslolW+RshaahGlTP+LsapapKscSNhs.hasYsc..pplhlphsKsF	.......................................................................................................Wphphuhshh.ppNlN.pustttph......................h.t...p..st..pu.pulsYphshp+p....hsl..t..sp....ahhththsstGp.hYhss+c........as-....h..s.h.phth..G.h.tapss.....p...pp...h.ulhPa.hp..pph..h......................usctastsh.................Gh..phph.shh..ls..p.Wphsssh.......p.htcp.cY...pcp...............pphsupt..h.h.u.s..o.l.h..a.h.h..s.s..p..t.h....hh.s..G.hs..a....+cps.....p-.......p.s.p..uh.pp..tu.l+h.G...hsp...past......G.lss.ph..p..h..u....a..scRp..Ycs...shh..................s.tR+Dcchphsh....u......l.h..+.c...p...l....p.a.h.GlsPpLsap.ap+s..pSNhs.hYpacp..pphhlphp+pF.....................................................................	0	27	48	65
+2218	PF04481	DUF561		Protein of unknown function (DUF561)	Kerrison ND	anon	DOMO:DM04313;	Family	Protein of unknown function found in a cyanobacterium, and the chloroplasts of algae.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.43	0.70	-5.42	5	102	2012-10-03 05:58:16	2003-04-07 12:59:11	7	3	94	0	40	445	219	236.40	57	91.19	CHANGED	MsN...K..lcsslcp+KAIKVISGLNNFNsspVlpIA+AuptusATYlDIAADPcLVcpVK.ulssIPICVSAl-schLhcuVtAGADLlEIGNFDSFYsQGphlsss-IluLVKpTRpLLP+TsLoVTIPHILsLcEQlpLApcLEuLGlDlIQTEGphouIS.....+scplschIcpSss....TLASTYsIS+sVsLPVICASGLSslTlPlAFuhGASGIGIGSuVo+Ls-ptcMVshlsElpsulSuspsh	.....................................................Lppuhpp+puLKVISGLpNFDtssVstls+AAptGGATaVDIAsDspLVc.hsp.plo.sLPlCVSuV-PctFssAVpAGAshlEIGNaDoFYspGRhFputEVLpLT+pTRpLL.PplsLSVTV....PHhLsLDcQlpL..A.pLVptGAD...II...QT.E....GGT.S.SpP.......hpsGs..LGLIEKAuP.......TLAAAauIS.....R.....A.....V.....s........lP.....VlCASGL.S.s.V.T.s.PM.A.I.u.A.G..AuG..VGVG..S..A..l....N......+....LNDplAMlAsVRuLsEALt....sh............................	0	6	26	37
+2219	PF04763	DUF562		Protein of unknown function (DUF562)	Waterfield DI, Finn RD	anon	Pfam-B_6057 (release 7.5)	Family	Family of uncharacterised proteins.	25.00	25.00	36.60	58.60	19.20	17.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.89	0.71	-4.96	6	19	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	2	0	13	19	0	138.60	41	24.59	CHANGED	phpcFL.hVltDEpEKcVlVVsscup.thcuLssculshLhcELpppGYSYLNIhSscscu.spVpERplLssc.pGRSFTVIls-LPlGssDIRsLQLASERIlVScph-AADAhASGC......KlLpa-c.pssWs....pcatsatcpV-cpt	...hpcFhhhlhhscpE+sVVVVsscu..sh.sLsspuhspLlcELppcGYSYLNIhuhcssu.hpVppRplLsss.pG+uFTllhs-.s.upsDhRsLQLASEthhsu+EhpAsDsYASGC......cllth-c.ppsWs....pcHttatccVccp..	0	0	0	13
+2220	PF04577	DUF563		Protein of unknown function (DUF563)	Waterfield DI, Finn RD	anon	Pfam-B_4026 (release 7.5)	Family	Family of uncharacterised proteins.	22.10	22.10	22.10	22.60	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.58	0.70	-4.42	219	1565	2009-09-11 01:27:59	2003-04-07 12:59:11	9	58	566	0	846	1505	506	202.60	16	44.06	CHANGED	tha....t.Hahh-h.lspl.hhhppthhpps..............hh...hst..thh...sahp......chl.ph.......hul..ttppl.ht....p...p.hhhp.......................plhhssssh.........ththhshhh...........thtphltpphthpt............................................ts.........+hhalsR........tst......pRplhN..pp..cl...h....phhp...............phu.......ap...hlp....sp.phs....hp-Qlp.las.suchlluspGuultNh.....lFh..ps..t....spllpl..s.....pthsht....ahtlsthhshphhhlhsps	.......................................................................................................................................................................................................................................................................................................h.....................t..........h.............t............t.hhh.........................................thhh..............................................................................thtp.hlhpthshsp................................................................tts.........plhhlsR...........sp..........pRtl...hN...ps......-l....h.............phhp..............................................phs................hp..........llp......hc...phs....................h.tptlp...lhs....su.chllusHGAuLssh....lFh...ss...........s.....usllcl...........hthp.t................ahthuph...shph......th.......................................	0	442	611	734
+2222	PF04483	DUF565		Protein of unknown function (DUF565)	Kerrison ND	anon	DOMO:DM04315;	Family	Predicted transmembrane protein found in plants, chloroplasts and cyanobacteria.  This family is also known as YCF20.	21.10	21.10	21.20	22.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.81	0.72	-3.81	19	173	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	110	0	85	173	161	59.50	33	43.19	CHANGED	Qpu-WDllsAulllshsEhlutlhYpph.........ppp.th......hlphlNhhKlGlhYGLFlDAFKLGS	................u.hDllsAsllVhhhEhlstl...hYptsh................................htp.th......hlphlNhaKhGlhYGLFl-AFKLGS........	0	16	55	75
+2223	PF04525	Tub_2	DUF567;	Tubby C 2	Waterfield DI, Finn RD, Eberhardt R	anon	Pfam-B_4998 (release 7.5)	Family	The structure of this family has been solved. It comprises a 12-stranded beta barrel with a central C-terminal alpha helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein [1]. In plants it plays a role in defense against pathogens [2].	24.50	24.50	24.50	24.70	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.36	0.71	-4.90	16	987	2012-10-02 20:44:47	2003-04-07 12:59:11	7	6	608	2	363	768	7	155.80	24	85.77	CHANGED	thhlss.ahsstthsLslhh+shhhsssuaslhDspGpllF+V-s.....hphscchhLhDssGpsLlol+c.K.....hhoLtspWplapusssp.......p.lFsl++s.....l......psahh..ssh...tppspsapIcGshhpcuhplhc..psspllApl+...s..pshhhGcDsasl.hVpsphDhuhlhuLlll	...........................................ht...................hhl.pp..h.hh.t.........s.c.p.Fsl....p......D.s.p.G......p.....lsapV-G..........ph....h..p.......hs.....c..phtl.......hD.s.s.G.c.......l...h.pI.p+..c...................hh.o.h...h.s.capl.h....ts.sp.p.....................h.as..l+Kp................................sFh....t....................s...h...................t..p....sh.shcl..cG.s.h..h...c....h..s.....aplh................p......s......p...s.....p.....llA.clp.....................p.......p...h.......h.th.......s.....s....s....asl...sV.h....s....h........ss...Lllulslh.................................................................	0	59	216	293
+2224	PF04601	DUF569		Protein of unknown function (DUF569)	Waterfield DI, Finn RD	anon	Pfam-B_4902 (release 7.5)	Family	Family of hypothetical proteins. Some family members contain a two copies of the region.	21.20	21.20	21.20	21.90	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.78	0.71	-4.76	7	184	2012-10-02 19:42:32	2003-04-07 12:59:11	8	6	19	0	119	175	8	140.00	37	47.43	CHANGED	MElFpcAcuVRLRS..pHDKYLhAD-DEEoVpQsRsGou+pA+WTVE.V..sp.clIRLKSCaGpYLTASNc.FLLGhTG+KVlQotshR..hDpss.-WEPlREGupVKL+oR.G.paLRuNGGlPPWRNSVTHDh.PHhSsTpc.llW	...............MEhFpcuphVRLRS...tp.sp..YLhAD-....Dt.....psV...sp...s...+......s.u..u.....u..h..s....Ah.WsVE..h..l..................s......s....s......s............h.........lh...L...+.S.s.Y.G+YLsA....o...st.......h....h...h..G.h.s..Gp......+....VlQs............t...p..................h-.s.sh......W....c..s.l..........+......c....G...s.......p......l...pL...+........s.t.....G.......pa..LR......ANG.......s.h....sW.csu.VTh.D...st.t..........................................................	0	12	63	92
+2225	PF01881	Cas_Cas6	DUF57;	CRISPR associated protein Cas6	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats [1]. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation [2]. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers [3].	23.60	23.60	23.70	23.70	23.40	23.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.12	0.71	-3.99	46	464	2012-10-01 21:23:39	2003-04-07 12:59:11	11	3	348	9	200	474	12	148.10	20	61.04	CHANGED	hsuLh....ppsphpls...s....tpaplccl..chhcp.ch.ppphpFpTL..SPlllpshh.........sphpphaltPp-pc.....FhchlppNLhcKYpth.....hucp.p...pchphch.....h+t.....+hlphK.......pth..l+uhhhh.Fclpus..cllchuY-sGhGpKNuh.GFGhlcll	...........................................................................................h.........t...h.ht....t.....ph.hl.ppl....phhp...p.........h..ppph..hhpsl.....S..Plllppt..............ptpshahpsp-..pc..........FtchlppNlhcKa..pth..............hspp.hp....pphphps........h...th+....h.phhph+....................shh.....lpuhh.sh.acl.....pus....c...ll.....phsa...ps...GlGp+sup.GFGhlch..................................	0	73	128	169
+2226	PF04489	DUF570		Protein of unknown function (DUF570)    	Kerrison ND	anon	DOMO:DM04330;	Family	Protein of unknown function, found in herpesvirus and cytomegalovirus.	25.00	25.00	32.00	31.60	16.80	16.20	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.45	0.70	-6.07	4	48	2012-10-03 01:18:03	2003-04-07 12:59:11	8	1	25	0	0	44	0	393.40	47	68.12	CHANGED	ss.u..hpsshp.pssaG+uI..Aohpp+.ppsh..R+HLshYpuhLhsIlcQYpp.hlPsptphpYcpGtIclushlls.spQlsutp......lYsWoolshPKhhuhtELaFLlsSscppslshpPhITKGGhhSu.hoY...Phs.SsshslshlpsslhMlPFlPa+hPhhhs.hhs...........sh.hLppttst.taGplp.lKp+shhhLullcsLTWppphshs.psphhphhtA.FhGohss..stlP.-shAhRhhsNspaphtsaEFoINl-Nlsls+spcKllGTLATssCcphsspLosENhPphLllpFELloshpcs.cLhFSsNPpLaFoGDlLNss..L.psPNhaELpVaAPYDlHFhsuppHhVpLslRYhphsDRp.hLVSsh.sEshFcTthslWtsssPL+lTLhSao.NLlLPQGT.lAsLhhl	..............ohhEuhR-s..spssYG+sl....p.cs+.l+..Rot...pHLosYcshLhtlscQYNp.sssspt+ApYhpGsIahuhsVIhsstpssshp.......YsWosllsP+s.shsELaFLLCSsptsusVhQPhITKGGhpouhhsa...s...tps....pss....phshl+spLshlPFVPassPcauV.FhT..tcsuh.....................h.hlp.....tAs....FGpho.VpRpGushlshhcpLoWhs+plhs.sppchTpYlA.FcGTh-s..uhhsu.scsWhs.+NVpYEhhsh.FolNV-SlsVsspp.RpLlGTluouhCcps.os.ploscNMPp..shpF.Ll.sotpRt.slhFSpNPoLFFoGDuLN.s..L.ppPssasLTVHAPYDIpFt.psppsVplDlRYsphsDR.CFLVuslPpE..stFaTGLoVWRsspPL+lTLhShT+ollIPQGTPIAsLY.l..	0	0	0	0
+2228	PF04672	Methyltransf_19	DUF574;	S-adenosyl methyltransferase	Waterfield DI, Finn RD	anon	Pfam-B_4601 (release 7.5)	Family	This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw from Swiss:Q82L35 suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22 . The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	20.00	20.00	20.00	20.10	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.57	0.70	-5.13	12	720	2012-10-10 17:06:42	2003-04-07 12:59:11	7	2	101	4	349	788	2	255.20	39	95.90	CHANGED	stttsspIDTo+PHsARlYDahLGGKDNYPVDcpAu-shhtshPthhtsAptNRsFhpRAVphLAt-.GIRQFLDIGTGlPTtsNlHQlAQplAP-oRVVYVDNDPlVLsHucALLsusP-GhTsalcADl+cPcpILp..cstcsLDFsRPVALhLlAlhHal...sDs-DshulVcpLh-sLPsGShLsLScsos-hsPthh...ctstshaspu..utshphRohp-lttFFc..GL-LlcPGlVssscWRP-ssts...........................sstthshauGVARKs	............................................s.....tlDsshPpsARlYDaaLG.GKDNassDRpsucphht....hhPph..h..t..hAptNRsFLpRAVRaLAs.c.GlRQFLDlGoG.lP.T.t.................s....N..........lHE.VA.Qpl......s...P..-...uRVVYVD.NDPlVLuHu+ALL.su.s...s.p......Tsh...lpADlR-PcpILst....pspchLDh.sc.PVALh.llulLHa.l.......sD....p.-......c.s.t.slV.pplh-sLssGSaLs.lo..H......s....o.....s......-....h.s.....s....p.t..h..........pt...s....t...p.h....h...p..ps........ss..s.h.....t...hR..opp-ltpaFc...GL-Ll......-......P.G......lV.s......sp....W...RP-s.sss.............................p.s.tt.h.hauG.VuRK...............................................	1	125	277	340
+2229	PF04746	DUF575		Protein of unknown function (DUF575)	Waterfield DI, Finn RD	anon	Pfam-B_6048 (release 7.5)	Family	Family of uncharacterised proteins.  Contains several chlamydial members. 	25.00	25.00	80.70	79.60	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.26	0.72	-3.98	6	20	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	2	0	15	20	0	97.00	55	18.45	CHANGED	AFDFoRPlCSRITNFALGVIKAIPIlGHlVhGl-WLlSph.tphls+PsFsSDVssIlKlEKstG+DHluRVEphL+p.RlslssED.sKVHG+hPpsPFs	AFDFo+PhCSRITpFALGVIKuIPllGHllhGl-WLlS+hhcphVo+PsFsSDVssIlKlEKlsGRDHIuRlEshLKp.RlsIssED.DKVHG+hPpsPF.u	0	0	0	15
+2230	PF04507	DUF576		Protein of unknown function, DUF576	Mifsud W	anon	Pfam-B_2120 (release 7.5)	Family	This family contains several uncharacterised staphylococcal proteins.	20.00	20.00	20.40	20.30	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.62	0.70	-5.46	29	2553	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	198	3	28	1021	1	231.00	55	98.31	CHANGED	MpahK+lsLhISlllLhlhI.uGCGh.s..........K--SKEspIKKSFsKTLsMYPIKNLEDLYDKEGYRDsEFcKsDKGTWlIpS-MshpsKGcshco+GMVLhlNRNTRTuKGaYhlcclp--pcthspsp-KKYPVKMcNNKIIPhcpIcDcKLK+EIENFKFFsQYGsFK-LcsYKsG-ISYNPNVPsYSAcYpLsNsDhNVKQLRKRYsIPTpKAPKLLLKGsGDLKGSSVGaKclEFTFlcsKcENIaFoDSlpFpPSc	............Mhh.p+lhLhIsh.ll.Lhlhl..sGCsh.p..............ptsuKEtQIKK.SFsKTL.sMYPIKNLEDLYD..KEG.Y..RDs..EFcKsDKGTWhI.Schshps.Kscphcs+GMVLalNR.NTRTsKGaYhVpphhc-pct.h..........p.s.pcKcYPVKMhsNKII.hcplcD-KLKKcIENFKF.FsQY.usFK-lpsYcsGDlSaNspVPSYsAcYpLsNcDhNVKQLR+RYsIPTpKAPcLhLKGsGsLKGS..SVGaKclEFsFscpKc-slhasDSlpapPo....................................................	0	11	11	27
+2231	PF04510	DUF577		Family of unknown function (DUF577)	Finn RD	anon	Pfam-B_3938 (release 7.5)	Family	Family of Arabidopsis thaliana proteins.  Many of these members contain a repeated region.	20.90	20.90	20.90	20.90	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.18	0.71	-4.57	17	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	9	0	49	54	0	158.90	33	38.91	CHANGED	l+EIpPLLIoCLp.pphp.-SphKlLtclVSpVAaplh.hpcssW.ELpDhIhShu.ppE.hKAhalF.sLs.sl.hc-Flh+hhcs.ll.chpphLhsPpc..scspsWsLAhpsshphuIpLl-ssh+.schl+clhph....hlcSV+cLVp+GhE.thlhRuhc-lEphVp+phphYphoc	....................hhplpslLIsCLp.pthp.po.hKlLtplVspVsh.pl..h.hpctsW.-Lt....-hIho.u..ps-...+AhhlF.sLs..l...c-Flh.hhcp.Lh.ch.phL.sPpp...cspsWsLAhpuuhphsIpll-sstp.schlcclhpp....hlcSl+-LVp+thE.thlh+uhcchEphlpcphphYphs.t.................	0	25	29	30
+2233	PF04669	Polysacc_synt_4	DUF579;	Polysaccharide biosynthesis	Waterfield DI, Finn RD, Eberhardt R	anon	Pfam-B_4574 (release 7.5)	Family	This family of proteins plays a role in xylan biosynthesis in plant cell walls. Its precise role in xylan biosynthesis is unknown [1,2]. Its function in other organisms is unknown.	20.40	20.40	20.70	21.70	18.50	20.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.34	0.71	-4.93	29	437	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	248	1	286	418	7	142.80	30	66.25	CHANGED	hEhphuh+slc+tps.hNlLshs.ssp.....pLhhstlscp.............hhpphccpaPslc.......scl.h-tccLhust.....................................tcpcW.hhhhss.cshht-........ashGslhRscsstsho..sslFVpcl..........pFhshEhtpsptGhsphhah	.............Ehphus+slp+tps..hslLshs....ssp.....pLhho.phs..cp............................hhpph.......c.....cpFP...p..h..c...........sph..hct-cLhutt..................................................hctcW.h.hhpt.c...shhp-...........ashGsLhRscsstths..ss.lFlhch..........pFhshEht.psptGh..hh.........................	0	68	151	223
+2234	PF01882	DUF58		Protein of unknown function DUF58	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of prokaryotic proteins have no known function. Swiss:P71138 a protein of unknown function in the family has been misannotated as alpha-dextrin 6-glucanohydrolase.	21.60	21.60	21.60	21.60	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.81	0.72	-3.84	161	3991	2012-10-10 16:07:06	2003-04-07 12:59:11	13	9	2067	0	1413	3655	957	85.30	25	23.95	CHANGED	st-ats.lRcY.psGDsh+pIcW+soAR........t.sp...Lhl+ca.ptpp.p.....tplhlhlDtsts.......................................tphEttlphsss.....lshthhp.....pspthul	................-atp.lRpYps.G.DclRpI-W+so.AR...............p..sc........hhl+..pa.cp-p.p.......ts.lhlhlDhsssh..h.stt.......................................................tch-hul.phsus......lshh.shp.....pssphs.............................................................................................................................................	0	508	1002	1244
+2235	PF04515	Choline_transpo	DUF580; 	Plasma-membrane choline transporter	Mifsud W, Pollington J	anon	Pfam-B_2258 (release 7.5)	Family	This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals [1].	22.10	22.10	22.30	22.10	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.83	0.70	-5.70	73	1097	2009-12-17 12:57:17	2003-04-07 12:59:11	7	15	292	0	722	1057	28	295.60	23	51.13	CHANGED	hhhllhshh.llhllhh..........................hhhppRI.hussllcpuscshp.ph.plhhhsllshllhhsahshashshlslhsptps....shps.s.....................................................................................tlhhhhhahlFuhhWhsphltslhphslA.GshusWYastpp....shPptsshsuhpRuhp.....YphGSlshGSLllullphlRhllchlppphpttt.....s.hhthlhpshpChhtsl-phlcahN+.AYlhlAlaGcuahpuAKcsapLlpp.sslcslhssslsshhLhluplhluhhsulluahhhph..........psshsashsshhhshlhuhhls.plhholhpsul-TlFlCaspD.ph.ppss	..................................................................................................................................h..hlhhhlh.thlhhh.hh..........................hh....hppR..l...h..sh..tllp.u.s.cslt...ph.thh..h..........h..sh.hsh.hhhhhh...hs..h.Wh.h..sh.l.h..l.hss.s..ps......p..t...............................................................................................tt...............hhhhhh.hahlhs.hhWh.sphlhuhtphslA.Gshusa....Yashpp.............shst..............h........s..l..h.s.u......ht...+sl.p...............aphGSl...shGS.Lll.sllp....h.hRh...........l.l..........p.hh.pp....phpttt.....................s.h.phhh.psht..C...hhhhl-..............p.hlcahNc..AY.........hhhAlhGpsFspuA+................psa.llh.........p..shh.cs..h......h.....hsp.........l......sshll....hh..u..pl.hls..h.hsu...hhuh.....h.hhp..................................t.th.phhh...h.sh.h..hs..h.h................h....uahls.phhhs..l...ht.sl-olalCas.D...h...........................................................................	0	287	424	583
+2236	PF04570	DUF581		Protein of unknown function (DUF581)	Waterfield DI, Finn RD	anon	Pfam-B_4765 (release 7.5)	Family	Family of uncharacterised proteins.	23.40	23.40	24.00	23.40	23.20	23.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.43	0.72	-4.68	42	427	2012-10-03 05:12:49	2003-04-07 12:59:11	9	3	27	0	245	398	0	55.50	39	30.63	CHANGED	stsstsstsstss.ssFLpsChLC++pLs..scDIaMYRG-pAFCSpECRppQh.hDEtp-	..............hs..........tsspFLpsChLCp+.pLs..scD.....IaM.YR..........G-pu...FCSpECRppQh.h.DEt.............	0	20	132	192
+2237	PF04518	Effector_1	DUF582;	Effector from type III secretion system	Mifsud W, Eberhardt R	anon	Pfam-B_2447 (release 7.5)	Family	This is a family of effector proteins which are secreted by the type III secretion system [1,2]. The precise function of this family is unknown.	21.00	21.00	21.50	22.40	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.21	0.70	-5.47	20	164	2009-09-14 12:27:57	2003-04-07 12:59:11	7	1	35	0	22	81	0	380.30	32	51.67	CHANGED	plpsphsshstspspFss..sshsshpshplasphssspstls.shhtssspthlsshpps..s.uppspphhppapstAssplpplpppIsphppphtchsstKAohsss.......hphupsshlpopPLtSAauSllLD+YlPpQpphLpsLtpclsaSNhAushhNsllchlssFsouslYYsLuSYlsQ.....ppGtstFssuhtpApstLscE+ppsppDlppspcApshlspllsplpsDs...clTsuQ+pclh-slssYptplsslhssLssLpshLssLpl.........hsssspscssFclps.......-sWhtpLpsLEuhllsG...hssusssGGhhslhsplpuDQQsYsshuQNQQLsLQhchouhQQEWTlVusSLpLLNQIaspLsRp	......................................s.psphpphs.tpppaps..ssts.hpthplh....sphpsspshls.hhhtshspthlsshppsh.ptuppspphhscapstupschpclppplpphppphpplsstpsshssp.......ht.ApsshlcshPLtSAauplLLD+YlPpQpphLpsLtpclpaSNhAushhNsllchlspFssuslYYNLuSYlsQ.........ptupshFssshppspspLscE+pphctDlpp.......sppApphlppllppVpsss...plTspQ+sclp-tlssYtppLsslhspLssLpshLssLsh..........sssspscssFclhu......tcpWhhpLpsLEstllsG...hssusssGGhhshhs.lpoDQQsYsshuQspQLtLQhphouhQQEWTlVusSLplLNQIatpLspp.....	0	5	5	18
+2238	PF04519	Bactofilin	DUF583;	Polymer-forming cytoskeletal	Mifsud W	anon	Pfam-B_2455 (release 7.5)	Family	This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localisation and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-10.41	0.72	-4.00	160	2175	2010-01-08 16:00:08	2003-04-07 12:59:11	8	16	1383	0	671	1765	1447	96.10	23	54.70	CHANGED	tsolIupssplpGslp.hsu.slpl-Gp..lpGslps.ps....plhlupsGplcGp.lpup.plhlsGp..lpGslpupchl.pltssuplpGclpssp.lplcpGuhhpG.phph	............................h..shlstshp.hpG.p...lp.hps....tlpl..c..Gp...l..p..Gs.lps..ps......plhlupsup..l.c...Gs..l.p..s...p....p.l.hl...s...G.p........l..p..G.....s.....lp.u...p.p..l.pltssuplp.G..s..l...p..s...pp.....lplptGuhhpGph..h.......................................	0	268	476	575
+2239	PF04520	Senescence_reg	DUF584;	Senescence regulator	Mifsud W	anon	Pfam-B_2571 (release 7.5)	Family	This protein regulates the expression of proteins associated with leaf senescence in plants [1,2].	21.50	21.50	21.50	23.40	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.18	0.71	-3.72	22	277	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	33	0	170	265	0	149.00	31	84.22	CHANGED	sth....ELsEsDla.ss...................................................pssusssshpsu......sss+th.th..............ssssssthtpSAPVsVPshuth..........pptcs.pptcs--p--t-ss.hlPPHEhlAR......Rcsuuh..SVhEGsGRTLKGRDLR+VRNAlhc+TGFhD	........................................................................................................t...-h.Et-lh.........................................................................................t.t....t....t........t.sthh..t..............................tstsssthhtpSAPVsl..Ps.hsphht...........................tttptt.t..tt.c.s.s.......c....pc..c.....s.......s.........ssp...hlPPHEhlA.R...................pptsuh........SVhE.....Gs...G.RTLK.GRDLp+VRNAVhcp.TGFl-.......................	0	18	95	134
+2240	PF04522	DUF585		Protein of unknown function (DUF585)	Kerrison ND	anon	DOMO:DM04368;	Family	This region represents the N terminus of bromovirus 2a protein, and is always found N terminal to a predicted RNA-dependent RNA polymerase region (Pfam:PF00978).	25.00	25.00	233.10	232.40	18.60	17.60	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.67	0.70	-4.98	5	16	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	6	0	0	16	0	246.00	51	30.16	CHANGED	M.SKFlssD.EYpVPSFQWLIDpSLEc..s.-sElAshVsc..s.....-PcsElTADGSLASFlLAVKPLVIG.Gpa-PPFDQARWGsCCcsVssls-uFTc++LIPhAEMARMLYLDI-GSFVDESEsDDWhPEDTSDGYsEYhuuDEsch.t...us-LppsLucEssshEh-EscEsoD.....SsPS...EhTLGDRYlsTsEEFtol-.SDYslTLNLhNPVEpRVullEDTascs-sD-.hspuPpYpERVSLcuLEAAGH	...MSKhhs--.sYpVPSFQWllDQoLEs..s.cs-sAthlsp..s.....-susElssDGoLASahhAVKPL.IG.Glh-PPFDQARWGpsCcsVhslspthsshtLIPhAEhARMLYLDI-GSFVDESEsDDWhP.DTSDGas-shusstsch.t...pochpp..hLup-usphE.cpsccToD.............sPs.....EhTLGDRYhshcEEFtol-.oDYDIoLsLhsPlEp.RVuhl.DTasHs-ssD.hsThPhYh-RlSLppLEAAGH	0	0	0	0
+2242	PF04532	DUF587		Protein of unknown function (DUF587)	Kerrison ND	anon	DOMO:DM04375;	Family	This family consists of the N termini of some human herpesvirus U58 proteins, and some cytomegalovirus UL87 proteins. This region is always found N terminal to the Pfam family UL87 (Pfam:PF03043), which has no known function.	19.30	19.30	22.20	199.50	17.20	16.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.32	0.70	-5.40	8	45	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	27	0	0	40	0	215.80	55	24.92	CHANGED	hp.psup-A..LIVcSsss..p+shsVPVaVNSaNLTpElSssEDuRLspssP..VDsE+lculFcsLapAuPsplcs-pDRsKllLsRLLLGPVAVPCYC-.EW-ss...............-YLscsuhtCpGPlLYVHRtRC+Cs..sstsshpFoVMcsahuTHVFRGLLSLpEWNs+LPslFCsC.....ssspsDRYshslLP+chSlaL-hYPYhLspLsRaLoVsEIDDhsNslI	......ush...phss-ALIVhusoA...hRVhsVPVaVsohNLTpELSssEDARhspstP..VssE+VcuVFtuLYpAsPsal.............cTEp-RsKlVLsRLLLGPVAVPCaCD.EW-sc...............-aLscssphCpGPLLYVHR.RCpCG....ssGpuLsaoVLcsHhATHVFRGLLSLoEWNpcLPslFCsC....ssuspp-RYsMAsLP+-hSlaL-.YPYhhVcluRhLoVsElDDhVsuh.o	0	0	0	0
+2244	PF04569	DUF591		Protein of unknown function	Mifsud W	anon	Pfam-B_2799 (release 7.5)	Family	This family represents a conserved region in a number of uncharacterised plant proteins.	21.00	21.00	24.30	24.30	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.21	0.72	-3.94	49	201	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	3	0	185	199	0	81.40	47	29.53	CHANGED	uGpR.........c...tpssupsspRs..ssspsGuppssp.....uctc+...p.GhhttsRGs-PoARIRppthDG..G..shRRRpPAApcG....Gssctso.R..................s+F.ustASst	................................................G.R........c..hpcss.utsGRRs..sssssGup+usp........Gcuc+....TGhhttsRGsEPsARIRpRtlDG....GthRRRQPAAtct....GNGDEsT..R..................GRFsusRASst...................	0	0	0	0
+2245	PF04574	DUF592		Protein of unknown function (DUF592)	Kerrison ND	anon	DOMO:DM04429;	Family	This region is found in some SIR2 family proteins (Pfam:PF02146).	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.87	0.71	-4.66	14	90	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	54	2	54	87	0	117.70	34	26.38	CHANGED	phhP..ptP.ppsl.ls+s..ssKalhstho+--olNARhaLKhaG.tcFL-sYLPp-lNSLalYaLIKLLGFplKDppLhssl.p.hp..hp.s.t..ht.....................t.pDPL-KKphl+LIKDLQ+AhsKVLuTRlRLsNFhTl-+Fls+L+sAKKILVLT	.............................h......................hhh.ths+cpshpsRhaLK..shhpFL-haLP.phso..lhhhIthLGFt.+-.thh.................................................pDsLtccphhcLIK.Lp+AlsKVLspRlRLssF.TlDchlptL+sA++ILVLT...............................	0	8	25	46
+2246	PF04578	DUF594		Protein of unknown function, DUF594	Mifsud W	anon	Pfam-B_2859 (release 7.5)	Family	\N	21.00	21.00	21.70	21.30	20.10	19.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.99	0.72	-4.52	66	634	2009-01-15 18:05:59	2003-04-07 12:59:11	8	22	16	\N	390	558	0	57.80	34	8.75	CHANGED	pLh.......htsppphWclluclWsEhLlYsA....s...pssupsHucpLupGG..EhlThlWhLhsHsGl	.......................hh.........ptpptWcllsclWsEhLhYsA..s......ps.ss.ptHAcpL.upGG..EhlThlWhLhtHhGl........	0	6	138	264
+2248	PF04591	DUF596		Protein of unknown function, DUF596	Mifsud W	anon	Pfam-B_5061 (release 7.5)	Family	This family contains several uncharacterised proteins.	25.00	25.00	26.10	37.00	22.60	24.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.53	0.72	-4.07	19	144	2009-09-11 22:03:20	2003-04-07 12:59:11	7	1	49	2	24	99	0	70.10	52	56.83	CHANGED	LD-G+LKLu.+KG-aI.pGoT-ELV-MFRpuFPs..SDEEh-.........tGlWFhs-p.CPhsAVWlaKGtt.....ENGEDYY-Ws	.LDEG+LKLu..++Gc..Fl.sGTo-EhVEMFRpuF.Ps...SDEEh-.............tGhWFhs-...pCPuGAVWVhKGt.....tENGEDYY-Ws....	0	1	12	21
+2249	PF04640	PLATZ	DUF597; 	PLATZ transcription factor	Mifsud W, Riaño-Pachón D, Mistry J	anon	Pfam-B_5458 (release 7.5)	Family	Plant AT-rich sequence and zinc-binding proteins (PLATZ) are zinc dependant DNA binding proteins.  They bind to AT rich sequences and functions in transcriptional repression [1].	25.00	25.00	25.10	25.10	21.20	24.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.53	0.72	-3.77	12	304	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	36	0	210	282	0	71.90	52	29.08	CHANGED	RR.sYHDVlRVs-lpKllDhSsVQTYlINSAKVlFLNcRPQsRssKG..........ssNsCpsCsRuLh-s.F+FCSLuCKl	................RRtSYHDVlRVs-lpK.l.lDlSsVQTYlINSA+VVFLN..cR..P.....Qs...R.s..sKG................................ss.stCpsCpRuL..h...D.s...a+FCSLuCKl.............................	0	34	136	177
+2251	PF04654	DUF599		Protein of unknown function, DUF599	Mifsud W	anon	Pfam-B_5550 (release 7.5)	Family	This family includes several uncharacterised proteins.	21.10	21.10	21.50	26.70	18.20	20.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.25	0.70	-5.19	46	411	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	270	0	210	414	55	205.50	27	85.43	CHANGED	hlulshhlhsWhGYshahpppstpps..olsshhsphRctWhpphl...sR-s+.lhDspllusLppusuFFASoslllluGlhslluss.......-phhslhucls..hsstsschhhplKllsLlhlFlhAFFpFsWShR.asasulLlGusP.....tp.........ststtshAppsupl.shAuppaNhGLRuaYFuluhlsWhhuPlshhhsolhlVhlLapR-FpSpshpsl	......................................lhlshhlhshhuYp..hah.hhpstpps...olhsh.sthRctWhpphh....pccpp..lhssphltsh.tusoFhASos.lllhuGlh.slluss................pph..tphhssls....h..ss.p...sphh.h...plKhhsLhhhFlhAFhpFshuhRhasasulLluuss......p..................t.ttt.hhsptsuchhppAuptashGlRuaYauhshlhWh.huPhhhhhsohhhlhlL.ap.h-hhSpsh...h................	1	47	122	162
+2252	PF00892	EamA	DUF6;	EamA-like transporter family	Bateman A	anon	Pfam-B_177 (release 3.0)	Family	This family includes many hypothetical membrane proteins of unknown function.\	      Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.39	0.71	-4.09	98	66028	2012-10-02 19:55:49	2003-04-07 12:59:11	15	83	4851	0	17444	56174	36728	125.00	15	75.68	CHANGED	hhauhshlhs+hhhpp.....hsshthsshphlhus..hlhhhhhhhttt.............hhshpthhhllhlulhssslshhhhhhu...lphssuspuuhlht.hhPlhshlhu.hlhLtEplshhphlGhllslhGlhllhh	.................................................................................huh.h.h.h..h..h..p..h..h..h.tt...........h.s...s....h.....h....h......s...h....h....p....h...h..h..u......s...........h....h..hh..h...h.h.h.h.tt................................h.h.h.s.h.p...t...h......h....h.....h.........h.....h.....h.........u...l...h...s....h....s.....l..s...h.....h.......h...h....h..hu..........l.p...t......h....s....s..........s...t..s..u..h....l..hh....h...t...P....l....h.....s........s........l........h..........u....h..........l..........h........h........t.........E............p........h.........s..........h.......h......p........h......l......u......h......h.l..s.l.hGlhlh..h.....................................	1	4905	10337	14119
+2253	PF04634	DUF600		Protein of unknown function, DUF600	Mifsud W	anon	Pfam-B_5411 (release 7.5)	Family	This conserved region is found in several uncharacterised proteins from Gram positive bacteria.	21.70	21.70	21.70	21.70	21.20	21.60	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.76	0.71	-4.18	15	1266	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	296	4	43	633	0	133.70	58	88.36	CHANGED	LsplYpEIAppIsshIPsEWEKVYhhApls-cuuEVaFaYspPs.S-EhhYspsIsccaNlsccpFhcphh-LachFc-LRctFK-sstEPWTShphshs+sGKhslcFDYpDhh.po-asphtRphhapYK+hGllPEs..E.-hEhlcc	................................LSphYNEIANcISuMIPV.EW..E..KVYThAY..ls..D..p..G.GE..V..hFNYTcPu...S-EL.YYosI.......s+....cYNlScplF....Dhh.......h-LYchFccLRslFK..EEs....hE..PWTSCEFDF.T.c-.G.K.LpVSFDYIDWl.soEFs.hG.RpNYYhYKKFGllPEh..EYEhpclKc.............................	1	15	23	33
+2254	PF04645	DUF603		Protein of unknown function, DUF603	Mifsud W	anon	Pfam-B_5498 (release 7.5)	Family	This family includes several uncharacterised proteins from Borrelia species.	22.10	22.10	22.20	33.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.99	0.71	-4.34	3	189	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	29	0	14	166	1	164.70	61	95.50	CHANGED	MKRAKRSFDDYVAYF+EGSLSDsEIAK+LGVSRVNVWRMRQKWESGEsS...VNEDSRVTISEDTFEHLLuQTF+SEVpARKVKSELDLERSNLELGFINAFKQYSSlELsSMhoKIEsLRuKIDSLNKpsNKKNtpsVNEE...INSLKlELDELIKECpIREMELYYECMKKLAsAHEVDSKSNY	........MK+sKRSFDDYlsYFpEGsLsDhEIAp+LGVS+VNVWRMRQKWESGEss............VNpDSRVTISEDTFEHLLuQTF+SEVpA+KV+SELDLERuNLEL..GFIpAFKQYSSlELsSM+o.KIEsLRsEIDuLNKuusKKNKpsVNt-...INSLKSELsEhIKECSIREMELYYECMKKLssApEsESKSNY..............	0	8	8	8
+2255	PF04646	DUF604		Protein of unknown function, DUF604	Mifsud W	anon	Pfam-B_5503 (release 7.5)	Family	This family includes a conserved region found in several uncharacterised plant proteins.	20.80	20.80	20.80	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.72	0.70	-5.16	17	290	2012-10-03 05:28:31	2003-04-07 12:59:11	7	9	78	0	208	320	1	203.90	35	42.72	CHANGED	QNlhFSYuMAaGGGGaAISaPLAstLu+h.DsCIcRYstLYGSDcRlpAChuELGVPLT+EsGFHQhDlhGslhGLLuAHPlAPLVSLHHLDhV-PlFP.sh..sRhsAl++Lhp.sscLDsupllQQSlCYD...........+..pppWTlSVSWGYsVQlhpuh..............lssRElEhPtRTFhsWh+pus.hssasFNTRPl.scs....sC.p+PhlFahssspts....sps...tThopYp+phhtt...spC.pashssP.sclcpIhVhp.+PsPphWp..+uPRRpCC	......................p.hauas.M.AaGGGGhAlShPLAptLs..c..h.DpC.....l...........pR.Y...s.....tl.....a.....G..S...DsRlpuCh.u......E.L.........G.Vs....LT..c....-.............GFHQ........h...............DlhGch...hGlLsuH.PlsPllSLHHh.-...h...h..pP.la....P.....th.....sp.t..u.l...phhh...t...shp.hDs.thhQpsh.CYs..............t..t.th...ohuluhGasl.lh...................h....ph.hs.pTF.sW.t..t.....a.hsT+......p......C.tpPhhaahpps................t.......hhs.Y.h............h....................lp.l.V.t................................................................................................................................................................	0	37	125	168
+2256	PF04657	DUF606		Protein of unknown function, DUF606	Mifsud W	anon	Pfam-B_5554 (release 7.5)	Family	This family includes several uncharacterised bacterial proteins.	21.80	21.80	21.80	22.00	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.66	0.71	-4.09	147	2941	2012-10-02 19:55:49	2003-04-07 12:59:11	8	4	1497	0	499	1852	371	136.10	27	86.54	CHANGED	lhhl.lulluGhhlslQsulNupLupt.lG.tshhAuhluahlGhlsl....hllhlhhp...t................shtt..ht......ss....PhWhal.GGllGshalhsshhhh.PclGsshshshllsGQllsulllDpFGhhGhsppslsht+llGlllllsGlhl	..........................hhlhslhuGhhlslQ.sslNupLupt.....hu....s............sh....hus....hlsahlGhlhh..hhlh...hhhp..s...............phtt..ht.........................sh.......sh.ahhl.GG.lLGshhlhsshhhh..sp..lGsuhshsh...hlsGQllsulllDpFGhhGs....tpshshh..+.llGslhlllGlhh...............................	1	148	281	409
+2257	PF01886	DUF61		Protein of unknown function DUF61	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Protein found in Archaebacteria. These proteins have no known  function.	20.40	20.40	20.80	21.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.59	0.71	-4.31	17	84	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	82	0	58	78	1	126.40	28	91.20	CHANGED	h-+hlphtltplNpclPtcRKoLpELLpE-+PhlhlpsGscHhhc+cELEhLpphlsp-.hthl+lPIllEhpSohtpGshhlpGct.ElKsIp+lLshchs...tpshlhlh+..l.plRRcLPTsTphhFlh	.............-+hlpttlpplNpphPtcR+oLp-LLpE-+Pplhlps.GppHhh++cELEhLpphls...tp.hphl+lPIllchsss.htpGthhlpGct.cs+slsplLGtcht......pshlhl.+..l.plR+tLsTsTphhFh................................................	1	14	29	46
+2258	PF04748	Polysacc_deac_2	DUF610; div_psaccdeacet; 	Divergent polysaccharide deacetylase	Waterfield DI, Finn RD, Yeats C	anon	Pfam-B_5949 (release 7.5)	Family	This family is divergently related to Pfam:PF01522 (personal obs:Yeats C).	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.16	0.70	-5.32	134	1399	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1342	3	291	924	146	203.80	39	64.31	CHANGED	IlIDDlGh....phtsscslhsLPhslThAlhPhsststphuptA...+ppG+ElllHhPMpPhs.......t.p.sstsLhsshsspclppplptshsplPtshGlNNHMGSthTpsppsMphlh......ptLppp.sLhFlDStTsspShAtphApphGlsshpRclFLD...sp.ps.ssIpppLpphhphA+p.pGtAlu.IGHPtsp....Tlps.LpphlspLppcslpLVslS..p.Llp	....................................................................IVIDDhGh...p.pspppl..lul..P.s...lolAllPssPp...uc-hAppA...+ppG+EVllHlPMtPls........t..p..slt.ssLpsphSs-EIp+hlcpAlspVP.aAl..G..lNNH...M....G......SthTushhuMpplh......psLc.ch..s.LaFLDShThuso.Ah.........+hApt.........h........GV.s.lc.R...c.V.FLD...cs.p........stusIcpQhpcAlclA++..pGssIA.IG..HP+.Ps....Tl.c.s.Lpphl.pL.sc..lsLVhsSsLl.s..................	1	98	175	231
+2260	PF04764	DUF613		Protein of unknown function (DUF613)	Waterfield DI, Finn RD	anon	Pfam-B_6084 (release 7.5)	Family	Family of chloroplast proteins of unknown function.  Some members have two copies of the conserved region.	25.00	25.00	91.90	91.90	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.72	0.71	-4.19	10	10	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1	\N	0	12	0	125.70	30	66.12	CHANGED	cYlYRchKccsYWppa.h..lslYVNsK..........+VG.............hscsIo-lEYhLLDlFLaGPLchclo-.YcplpphlpcRsp+Ycchhcc.cplsG.....INIlFs...phsapchLpscYphcEhlssspILplYlls	...........pYhYRc.+ccsYWppa.h..lslYVNsK.....+VG...................hscsIo-lEYhLLDlFLaGPLchclo-.YcplpphlpcRsp+Ycchhcc.cplsG.....INIlFs...phsapchLpscYphcEhlssspILplYll..	0	0	0	0
+2261	PF04751	DUF615		Protein of unknown function (DUF615)	Kerrison ND	anon	DOMO:DM04973;	Family	This family of bacterial proteins has no known function.	25.00	25.00	39.40	39.00	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.90	0.71	-4.58	90	1331	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1309	1	252	777	138	159.20	49	85.34	CHANGED	--...-....hsSKSphKR-hcsLQcLGpcLlsLspspLs+l....PLs-p.LhcAltpAp+l..pppEA+RRQlQaIGKLMRpt....Dh-sIppuL-php..................................spppppstthHplEphRD+Lls.....pss..............sulsphlppaPps.DRQpLRpLlRpApKEttp..........sKs....s..........+uhRcLFphL+c	..............p--.E.haVSKSElKR..DuctLpcLGtELV-LucssLcKl.....PL---..LtsAIchAQRI...cpEuRRRQLQhIG.KhhRpp....DlE...PI...cpALDKL+............................................................N++...s..Qps...shh.....H+LEplRDRLls.....pGD...................sAls-l..lshaPcA..D.....R........QpLRsLIRNAcKE+pt..........................................NKP......P....................KuhRpIFQaL+-...............................................................	0	54	129	196
+2262	PF04765	DUF616		Protein of unknown function (DUF616)	Waterfield DI, Finn RD	anon	Pfam-B_6152 (release 7.5)	Family	Family of uncharacterised proteins.	21.40	21.40	21.60	21.40	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.98	0.70	-5.27	13	242	2009-01-15 18:05:59	2003-04-07 12:59:11	8	14	63	0	143	231	87	269.50	35	55.71	CHANGED	N..........LsYlpt-p..s......t.spFGGp.ShpcRcpSFphppshs.VHCGFh+......psGF-ls-p..................D+thMcpC+.VVVuSuIFusaDpl+pPps..ISchoccsVCFhMFVDEpTLstLcpcssh...hDssthVGlWRlVlV.......+NLPYsDsR+NGKVPKhLsHRLFPsu+YSIWlDuKhcLslDPhLIL-pFLWRpsusaAISpHhcRasVa-EA.AsKRhpKYsc.suIDhQhchYpp-GLpPa..SssKhPlsS...................DVPEGulIlRcHsPhSNLFSCLWFNEV-RFTsRDQLSFAYlh.Kl+s.....saplNMFpsCER+slsh.apH	..........................................................................................t.....................s.FsG..ohtpRppoa..........htts.p.l.CGFhp........tsGac.hsc....................Dh..hppCc...llVuoslFu............s.D.lppP.hs.......hsphoh.p...plC.Fhh..FhD-.o.thhpp.sph.........sttthl.GlW+llll.......+sl.P.a..s.D.R+sGK.....................lPK.hLsHRLFPss+YSIWlDuKlpL..h.s.DP.h.h.lLE.thLW..+..ps..sshAISpHhpRpsla-Euttstph.........pKasp.stl-......QhphYp.p-Gls.a...tsphs.h.s...................tlPEu.ulIl.R..cHs..s..ho..NL.F.sC.L...WFNEVs+.F.T.s..RDQLSFsal..h.+lp.......hth.MF.sCthpthh..hhH.......................	0	25	94	119
+2263	PF04768	DUF619		Protein of unknown function (DUF619)	Kerrison ND	anon	DOMO:DM04985;	Family	This region of unknown function is found at the C-terminus of Neurospora crassa acetylglutamate synthase (amino-acid acetyltransferase, EC: 2.3.1.1) (Swiss:Q12643).  It is also found C-terminal to the amino acid kinase  region (Pfam:PF00696) in some fungal acetylglutamate kinase enzymes.	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.18	0.71	-4.84	33	416	2012-10-02 22:59:21	2003-04-07 12:59:11	8	16	240	39	279	450	57	166.10	28	26.44	CHANGED	sLpKELFTcoGuG.TLlRRGh+lhptsohcph.....................shc+L+sllpcsh....ps+tslspYlcpl.cpp.hpsYss-s..h-ulAIV.....cpss...........................................phshLDKFslocsuhhs.sVuDslFssl.p+-FPp.LhWps+cssss..pWaFs+ScGohp.............csshhlFWYG................lpchsclpphl.......pphsst	.............................................................l.hclFotpuuu.Tll++G.....plhhhsshpph..........................Dhs+Lppllpcsh........tt+hslpcYl.ppl.ppp...hphh....h....sts.........hcusAIlh.....s....t.s............................................hsaLDKFslhcsu.ts.uluD.lassh...+.....ccaPp.L.......hWp...u+p...s.s........sp....tWaFc+usGohp.................psthhhFWhG...................htshpp..phht.h...p..............................	0	85	157	226
+2264	PF01887	SAM_adeno_trans	DUF62;	S-adenosyl-l-methionine hydroxide adenosyltransferase	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [1]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [2]. This family used to be known as DUF62.	25.00	25.00	26.30	26.20	22.70	23.50	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.59	0.70	-5.33	121	1173	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	1120	112	316	783	493	260.10	40	93.36	CHANGED	hIsLhTDFGhpDsaVushKGVIhsl....s.PsspllDlTHplsshslhpuAahLtpshtaFPpsTValuVVDPGVGopR+ulsl....css..s.taaVuPDNGlLoh....lh...........................pth..............tcshclsppp..............................thSsTFHGRDlFAPsA.AtL..ApG.hshpplGptl..............sslsclsh.ps..phps.....s......tlpGpl.lalD+.FGNllTNltsph..........hthuc....phplph..........tttt.............................................hhthscoau...............................clt.Gchl.shhsStGhlElAlsp......GsAuphhulphG..cp.lpl	..................................h.llLQoDFGLpDGAVuAMhGVhhph........s....s...s.l.+IhcLTH-IsPasIacuuYRLhQ.T.ssYW..........Pp..G.T.lFV.SVVDP..G..V.........Go.c.R........+S..llscTt...pspYhVoP..DNGoLoh....lt.c.................phGI..........pplhEIsEhts....h..........................p............cpSaTFHGRDVaAYsG..A+L.....AuG..IsFE..plG..spl..............s.spl.lcLs.h.ps..thpcs.................tlpGsI..Ilss.+.FGslWTsIspc.h........phthphG.c.phpVsIhpts.........................................hatsplsascSFu...............................DV.p...G.pPl..lYlNS.L.h....plulAlNp.......Gu....FuctaplusG..sp...hh...............................	0	118	221	276
+2265	PF04788	DUF620		Protein of unknown function (DUF620)	Waterfield DI, Finn RD	anon	Pfam-B_6213 (release 7.5)	Family	Family of uncharacterised proteins.	20.40	20.40	24.20	25.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.56	0.70	-5.21	20	186	2009-09-10 16:40:51	2003-04-07 12:59:11	7	5	27	0	112	174	1	218.50	52	58.66	CHANGED	MYAhG+V+MsssEhps....ustthsp..........sssus-tGuFVLWQhsP-hWhlELVVu.GsKVsAGSDGKlsWRpTPWls.sHAu+.GPsRPLRRhLQ...............................GLDP+oTAslFusAt....ClGEKtlss-DCFlLKlpss.usLpupSs..ussElI+HslaGYFSQRoGLLlplEDSpLhRlpo..ss..stulaW.........ETohpShlpDYRsVD...Gl.lAHuG+ossolhRF...........G-sstst.spTpMEEtWpI--VsFNV.GLShDsFlPP	.....................hYAhG+V+M....hssEhpt...ustsstt.................sttssE.GsFVLWQhsP-hWhlELsVu.G..s.KlpAGssG+lsW..RpTPWhs.uHAu+.GPsRPLRRhLQ.......................................................GLDPho.TAslFus.Ah....ClGEKplssEDCFlLKLps-stsLcuRSp..ussElIRHslaGYFSQRTGLLVplEDS+LhRIps..su.......s-slaW.........ETThpShlpDYRsVD.....Gl.IAHuG+osVoLhRF.............G-sshsp....s+T+MEEsWsIEEVsFNV.GLShDsFlPP...............................	0	10	64	89
+2266	PF04822	Takusan	DUF622;	Takusan	Mifsud W, Eberhardt R	anon	Pfam-B_3835 (release 7.6)	Family	This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity [1].	25.00	25.00	25.30	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.71	0.72	-4.22	13	539	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	34	0	235	892	0	82.20	37	22.31	CHANGED	sR+TSSpssplocpptc.cclEcLph-l+hIspERsELpchLshahpsshshR......lNspaphL+pp+cph...Mhshcchp.pIh-AhE	............tpsSo.ss..l.ocpppphpclE..cLKhcl+plop-p-EhpsILshah.....cslNhR..............hNsEaphlKpQH-cs...MhDhp+MpppIhpuhp.......	0	1	4	20
+2267	PF04844	Ovate	DUF623;	Transcriptional repressor, ovate	Mifsud W, Eberhardt R	anon	Pfam-B_4487 (release 7.6)	Family	This is a family of transcriptional repressors. In plants, these proteins are important regulators of growth and development [1,2].	25.00	25.00	39.40	38.80	23.70	22.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-8.97	0.72	-4.17	44	411	2009-09-11 05:52:17	2003-04-07 12:59:11	8	6	28	0	276	364	0	60.00	42	21.11	CHANGED	SsDPhpDFRcSMhEMlspptlt.........shscLc-LLtpYLsLNupcpHshIlpAFs-...lhhs..Ltus	.........SpDPhtDFRcSMhEMlspptlt............shc-Lc-LLtsYLsLNup.caHshIlpAFs-...lhhslh.s.............	0	25	150	222
+2268	PF04854	DUF624		Protein of unknown function, DUF624	Mifsud W	anon	Pfam-B_4640 (release 7.6)	Family	This family includes several uncharacterised bacterial proteins.	21.50	21.50	21.60	22.00	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.55	0.72	-4.12	65	1340	2009-09-11 11:23:42	2003-04-07 12:59:11	9	2	753	0	194	770	11	76.80	25	35.89	CHANGED	lshLNlLWlhhs.........................LhGlslhGlhPAosAhaslh++ahpsc....css.lh+sFapsaKcpFhcushlullhhhhshllhlsh	...........................................hhhNlLal..................................................lsulsl..lsl..GsApsulhpshhc..htpsp...........c.....s..........sh+pa....ap.sa....KpNFh.pu.h.lhhhhlslshllhhs...........	0	75	133	155
+2269	PF04776	DUF626		Protein of unknown function (DUF626)	Kerrison ND	anon	Pfam-B_2357 (release 7.6)	Family	Protein of unknown function, currently only identified in Brassicaceae.	25.00	25.00	34.10	33.00	19.00	21.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.85	0.71	-3.76	16	91	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	2	0	85	109	0	106.20	33	38.53	CHANGED	slPca.s-ssh...psp.caY..lccS-lpps.-WlpLYhElslhsp.csp.hppt..lssLcIlpVslcT.ccshpss.c..LpApsAlhYIsa+shsps+.......hGpth.-RtAIlRRhhDtp.uphsL	.................hPcW.s-ssh.....pcp.+aY..lpcSElpps..-WlpLYhElulhsp.cth...hpt......ht.LcIhKVsl-Tpt..pshcsspc..LcApsAlhYIoa+sh.sts..........s.th.-cpAIVRRshDtpsGphpL.........	0	23	23	23
+2270	PF04781	DUF627		Protein of unknown function (DUF627)	Kerrison ND	anon	Pfam-B_2475 (release 7.6)	Family	This family represents the N-terminal region of several plant proteins of unknown function.	20.40	20.40	20.40	20.80	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.12	0.71	-4.45	17	70	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	12	0	49	65	2	113.40	33	10.00	CHANGED	chAcchaspGsaIKALcllEDhIph+tccps.h.hlHhhQGplFhcLApcTE.NsDlKhsYLLuSVpCaScshtLsshs.........AhSLapLuppluSshaYKKslpKAKpuLSlpts.cs	.......cAhshhtcGs+hKALcllcDhlscHt.......csp.....hlHphQGslahclAtps-...ssssKhtaLhuul-shocsstLus.u.........ApuLapLApcht.spaYc+slpcu+cuLSlpss..s.....	0	18	27	31
+2271	PF04780	DUF629		Protein of unknown function (DUF629)	Kerrison ND	anon	Pfam-B_2475 (release 7.6)	Family	This family represents a region of several plant proteins of unknown  function. A C2H2 zinc finger is predicted in this region in some family members, but the spacing between the cysteine residues is not conserved throughout the family.	21.50	21.50	21.70	22.30	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.77	0.70	-5.97	14	139	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	16	0	82	125	0	300.70	25	30.08	CHANGED	cpL+oaWhGLDschKRsFhKVslsKLhoaVpsh....asccsp-sLcpsLs.A+pst+WpFWhC+s.CSc+F.ssE-CKpHl-ppHsucacPspppchsppIscsWActI.SsGsW-PVDssAAlchIKsRltcVKtFs...............YpNGW.................................sc-WPLAsDE..ERuKLLKEI+.lLVthh..-pKlLSCSlRDWlhpaslcaL.tpLcVScpsL.s-spLlcTPQSICFL-sc-LspILcaL+plK.....scRDDGssLVs+uV-uhhcsopVKE+IDhDsphS.hLLLD+RLLpscph......ph.DDEGolssa-ssshYscs.spGDcIlSWLh.DhsplDcp.....FPpsl.....+tHNh-IWlAVLRAVphTsRpLto+YsKKhphlsY-suLstsEslChpEDcRRcsh.c-QhspYASlLs-cCEEhl.c......lssKhFLssV+DVLctAspPsF-hhs.c-C....hshI+phco....lsDD.hVlKSlthL+pllppKV	.........t..h+paWsu.h.s.-p+c.s.FLpVslscLpuahpsh.......tp..pp......stcslscsl..sas+c..sppWpFWhCsh....C.....s......p.+.FhsscphhpHlppcHhs.p......h.......phpp...h.sp..plspt.hchl.....WpPh...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	20	35	52
+2272	PF01889	DUF63		Membrane protein of unknown function DUF63	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Proteins found in Archaebacteria of unknown function. These proteins are probably transmembrane proteins.	25.00	25.00	37.80	34.50	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.79	0.70	-4.32	13	123	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	87	0	88	133	119	269.70	27	93.11	CHANGED	tIp-Fla+YYI-PIht.cpGYNhVNTlTYAlILulslahlY+.hL++L+IclD-+FlhuslPallhGuolRVlpD..uGllpsPhoYlhlTPhIaFLlFslshhsLhluhpl.ptt...t.Yh+laushGlshsllsLhhLl...hppp..lhcsallshll.sluoshssllYhlh+h.h.hshhpc+LshhllhuHhlDASoThlGI-h..l.GYhEpHVVPsaLI-hhGoAhsMaPLKlllllsllYIL-p.htc-....pl+phlhlslllLGLAPGlRsshRMlhGl	..................................h...t..GYs.lsplsYullLhlulhhlhp..llc+......L.cIplD.c.chhhAlhPahlhGuslRslpD.........s........G...........l..........l..PhshLhlTPsIYhslhhls...hssllluhtl.ppt.....ta.p.....h..hhshGslhh.hhsl...h..hLh......hptp....h..hp.h..sh..h..hll..sl..u..sh.hss.lh.....a.hlh+h.........hph...h..p..sh.h.shhllauHhlDusuTslGl-h.......h..G....Y.....hE....pH............sl............sphl............l.........-............h.........h............G............s............ua...s.........hhslKlhlhlsllal..hsc.lp--....phtpllhlslhslGLuPGhRshl+hhhtl......................	0	13	48	72
+2273	PF04816	DUF633		Family of unknown function (DUF633) 	Finn RD	anon	Pfam-B_5077 (release 7.6)	Family	This family of proteins are uncharacterised have no known function.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.37	0.71	-4.98	13	1587	2012-10-10 17:06:42	2003-04-07 12:59:11	7	4	1567	12	231	1139	75	199.30	36	86.45	CHANGED	lsDIGSDHAYLPhaLlpsshsptulAGEVscGPapuAhppVpcssLsc+IpVRluDGLuslcpt-.l.DslsIAGMGGtLItcILEpGpc+Lttlc+LILQPNspt.pLRpWLpppsapIhsEpIlpEcsKhYEIlVsE+upp.......h.osp-lhhGPhLhc-+sslFhpKWppElp+lphlhtpls.....scpsctchptlppcI.phlc-	........................................................................lADIGSDHAYLPlhL.lppshhpp.AlAGEVsp...G...Pap...u...A......hpsV.........p.........t..........p......s.....L.......p..-........c..........IpV...R.Lu....s..GLs....s....l.c.p.........-......l...csIsI..A...GM....GG....p....L....IscI...L-..p.G..t....s........+.L..........s.......s....h..p...+...L..IL..QP..N...h...pp....ppLRpaL.pps.........apIlsEpIlcE.su+hYEIlVs......c..........h..upt..........................ho.pt.-l....hF...G.Ph....Lh.p...p.p.s..s..l..Fh..pKWp+E...lpphpphhpplt.........ppp.......p.....c.ht..tltpcl.t.l........................................................................................	2	89	145	191
+2274	PF04827	Plant_tran	DUF635; 	Plant transposon protein	Kerrison ND	anon	Pfam-B_2859 (release 7.6)	Family	This family contains plant transposases which are putative members of the PIF / Ping-Pong family [1][2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.30	0.71	-4.94	5	275	2012-10-03 01:22:09	2003-04-07 12:59:11	9	11	33	0	143	891	1	132.70	41	47.04	CHANGED	scYL.RuPsAsslcRLLplGc.RGFPtMlGSlDCMHWcWKNCPTAWcGQYTRGcp+.PTIlLEAVASaDLWIWHAFFGsP.GSNNDINVL-pSPlFsDIlpGsAPplpYhVNG+QYNhuYYLADGIYPcWATFVKSIRpPQsEK+KLFApcQEusRKDlERAFGVLQARF+IVtsPu+lWspscLusIMpACIILHNMIVEDERDhs	...........................................................................................................t.................................................................................................................................................tt.Nthp...hlt...s..l..h...............p...G..p...s...s........h..p...a......lN.....tp.........Y..p...h......s.Y.Y.L.s...D..u.I.Y...P..pa..s...s....h......h.....p........o...I.........................P..........s.....t......+......t.p.h.auptQ.Eu....sRKDlEpAFGV.......LQsRatIl.pt....P....s....p.h....a.p.t...tl.t..l...hh...uClIhHNM.IlEDEtt.....................................	0	20	63	102
+2275	PF04828	GFA	DUF636; 	Glutathione-dependent formaldehyde-activating enzyme	Kerrison ND	anon	Pfam-B_2779 (release 7.6)	Family	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.87	0.72	-4.04	59	3736	2009-01-15 18:05:59	2003-04-07 12:59:11	9	25	1139	16	1716	3480	2625	89.40	22	58.89	CHANGED	hhCHCppCp+toG.usass.shhtpp.slp....hhpG...thppap......susshp+.hFCspCGoslah......tsttss.....hhhlthGsl-ps.......pthpPp.hcl.aspp	............................................................................h.hCpCshC........p........+.........t.sG.s....h..hh.shhs......ts....s.lp..................h..h..p.G...t.....plptap.........................................ssptsp....+.....hFCspCGs...lah...........ptpsss..............hht...l.s..h..u.s..l-ss..........p.h.......t......t..............................................	0	364	828	1304
+2276	PF04830	DUF637		Possible hemagglutinin (DUF637)	Kerrison ND	anon	Pfam-B_2732 (release 7.6)	Family	This family represents a conserved region found in a bacterial protein which may be a hemagglutinin or hemolysin.	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.49	0.71	-4.62	30	397	2009-01-15 18:05:59	2003-04-07 12:59:11	8	83	154	0	54	380	8	148.40	36	13.38	CHANGED	ussAu.............l......uuhuosAusuhlsspGshttshK.lspusslKuhssuulTAGlssGl......................s.s......s.ssshs.thstuo.sslspthss.sspushsAulsTAI.pGGSht-...sLtsuh....ssshuAtuAstIGs..................hshssstss+lhsHAhlGCAuutAsGu.........cCtsGAlGAus	.............................................................htsAA.huSLsopAuVuhINNpG.s.......l.upsLK-LupusslKphssushTAGhhsth................................................hh.sshst.o.tth.....s.splssslssus.uuhls..TAl.sG...GS...LcD......NLtsshlusllsshpu-uAspItp............................hspshls+phAHAlsGC....suutsstu..........cCpsGAIGAuV.......	0	18	31	43
+2277	PF04829	PT-VENN	DUF638;	Pre-toxin domain with VENN motif	Kerrison ND, Zhang D, Iyer LM, Aravind L	anon	Pfam-B_2732 (release 7.6)	Family	This family represents a conserved region found in many bacterial porlymorphic toxins which is located before the C-terminal toxin modules [1][2].	20.30	20.30	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.69	0.72	-4.42	32	725	2009-01-15 18:05:59	2003-04-07 12:59:11	8	157	252	0	136	722	0	52.90	36	4.05	CHANGED	sssp...LoEcpKQplosLupLAAGlAuGlsGss........s.sAssGApuucsAVENN.tLu.shps	.............sspLo-ppKppls.uh.up.LsAGlsu....ul.sG.s.s...............tsssuApuucsAVENN.tLs...t.....	0	16	63	98
+2278	PF04842	DUF639		Plant protein of unknown function (DUF639)	Kerrison ND	anon	Pfam-B_6010 (release 7.6)	Family	Plant protein of unknown function.	24.30	24.30	24.70	24.50	23.70	24.20	hmmbuild  -o /dev/null HMM SEED	683	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.16	0.70	-6.37	4	126	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	22	0	82	122	0	514.10	35	90.47	CHANGED	pcht-h....s.ps.sshp.hPc..LS.lANsVVpRCS+hLslosc-LpcpF-sph..ulpp..TauRpFlEaCsF+sLSp.s.phhspLpDtpFpRLhFDMMLAWpsPssssppuh.pt.sp.p.......................h.h.V-cctoVGpEAFsRIAPslPhlADhIss+NLFcsLTouTGp+.Lpa.lYDtYl+pLcKhhKth+oppssphhsh.hucsEhlLch-Gs.sstPVL+Hls.ouWPG+LTLTspALYFEuhslhuh-sshRhDLocD.KpslKPthTGPLGspLFDKAlsYpShsh.EslVhEFsEhpGpsRRDaWLsIlpEllhlHpFlR+a..........plpG.l..t+pEhlu+AlLGIhRlpAlpEhhplsssphKsLL.FsLh-plPtGDhVLEsLA.ph......sphtspRssp..uusthh+.....s.ss.chlspl.G..............s.pstsphtspphlVG.....-hsVu-lssLEpAlcpSRpchchlEtAQATlstlchcGIsoNlAVhKELhLPh..hh..h.plhhWp-PhhossFhhhsohhIaRsWlsallsssLlalAhhMhh....pRph.s+sK..ttlpVps.PspNshEpllulQsulppLEphlQcVNVsLLKlRulhhShhPQtospsAluhlVlAohhAlVPhKYllshshV-hFTRpss.hR+tSs-+hpRRlREWW.plPAAPVhllpsps	..................................st....................h....LS.hAs.slpphu.ph.shsspcL..ppF-.th..t.....s.u..RphlEaCshphL.t....ssp.htsh..LtDttFpRLhashMLAWEsPss..psp..............................................p.hVu.-AFs+luPshshhsDhhssc.hFcsLossost.+.Lpa.hacpYlptlp.+.shcthpt...t..s.t.h......h...p.s.EhlLpltus.sppPVlpa.s.osWPG....+LhLTspALYFEuhtl.hshppshth-Lsp.-..pp.lc.thsGPhGspLFDpAl.hpS.shs-shhhEFs-htuphRRDhWhuhlpEllhha+Flpca............pl.s..h..t+tcshspAh.uIhRhpAlpchhph.ss..cthL.FshhpplPtGDhlLpsLs.p...........t...ptst.......tss...t........s.....t..h...h.h................t.....pttt..h..t.....ph.h.uths.lptultpshpp.chlphspATl-tspl-GlssNlslhpELlhPh..hh..h..lhtW-cPhhohshhhh..hhlh+thl.ahhs..hhh.shhMhh....h+...t.tp..ht.l...l...s.ss.s....shppllslppuhpplEt.......hlQss.NlhLLKhRslhluh.s...........p..........................topphhhhhlshAhhhhhlPh+hllhhhhhp.aTpp....Rp..sc.ph.phh+EhW.pIPssPV.l.....p.................	0	13	46	59
+2280	PF04852	DUF640		Protein of unknown function (DUF640)	Kerrison ND	anon	Pfam-B_6053 (release 7.6)	Family	This family represents a conserved region found in plant  proteins including Resistance protein-like protein (Swiss:O49468).	25.00	25.00	32.40	27.30	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.60	0.71	-3.97	15	226	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	24	0	141	225	0	123.60	63	54.52	CHANGED	ssspsutsuspssss...sh.SRYESQKRRDWNTFsQYL+Nc+PPlsLsp..CuusHVL-FL+Y..........LDQFGKTK.V....HtpuCsaFGpPsPPuPCsCPLRQAWGSLDALIGRLRAAaEE.s.G..GpPE.....sNPFuu+AVRlYLREVR-o	..............................................sssss............ss...s..SRYEuQKRRDWNTFsQYL+NHRPPLsLup..CSGAHVLEFLRY..........LDQFGKTK.V....HstuCsFFGp......Ps......PP.........A........PCsCPLRQAWGSLDALIGRLRAAaEE.s.G..GpPE.......................sNPFuARA..VRlYLREVR-.h...................	0	23	87	111
+2281	PF04862	DUF642		Protein of unknown function (DUF642)	Mifsud W	anon	Pfam-B_4723 (release 7.6)	Domain	This family represents a duplicated conserved region found in a number of uncharacterised plant proteins, potentially in the stem. There is a conserved CGP sequence motif.	27.00	20.00	27.20	20.50	26.70	19.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.21	0.71	-4.58	56	419	2012-10-03 19:46:52	2003-04-07 12:59:11	7	25	70	0	246	418	17	157.70	32	51.47	CHANGED	GLL.NGsFEpuPptuph.puot...lh.GppuIPsWclsGh.VE.YIsuGppp.GsMhLsVPcGsaAVRL...GN-AS..IpQpls.VptGthYolTFuAA..........RTCAQt....EpLsVSVs..s.....p...suslPlQTlYossGWDoYuWuFpA.pp.sslplsh.HNPGhp.-DP......uCGPlIDuVA.IK	.........................sll.NGsFEpuPh.....ssoh..........l..sp.sslPsW...hl...p.u.....h...Vc...YIsusphp...................VPp...GspAVcL..........Gp..Euu......IsQplp..ss.GphYsLoFusu........................csC.sts....p..t.l...s.Vplhs.............p.....stplsh.p...oh.h...s.....s.s..Gacshu.hsFpA..ss..splthh....ps.shp..-Ds......hCGPllDsVtl...................................................	0	35	131	191
+2282	PF04867	DUF643		Protein of unknown function (DUF643)	Kerrison ND	anon	Pfam-B_6086 (release 7.6)	Family	Protein of unknown function found in Borrelia burgdorferi, the Lyme disease spirochete.	25.00	25.00	44.00	67.60	22.90	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.68	0.71	-3.68	3	80	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	22	0	5	64	0	111.60	69	64.24	CHANGED	INEISDFYDNLScclKKE....INKLYtTcQlTLKQK+QhYSuacuhQEYsIKTGKSl-EIls.IIDPsKcFIKDVLKcKaLIKKYKNFpNhKVDaSYKKGMLEKCLEKLGEccShtF	.......INEISDFYDsLS.sTKKE....IsKLYGscQLTLcQK+chYpuahuIQEYKRKTGKSI-EIls.IlD.PAKpFIKDVLKDK....aIIEKYKNFQNhKhDhSYKKGMLEKCLEKhGEchSscF........	0	5	5	5
+2283	PF04870	Moulting_cycle	DUF644;	Moulting cycle	Mifsud W, Eberhardt R	anon	Pfam-B_4889 (release 7.6)	Family	This family of proteins plays a role in the moulting cycle of nematodes, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle [1].	22.00	22.00	22.10	22.40	21.30	21.90	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.08	0.70	-5.36	9	114	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	9	0	113	89	0	257.80	25	45.59	CHANGED	PhuhIsKpLpphV+shKpK..-..pKWp-llp+Ipccspcl+p+Kptcph.Rp.hth...t.............ht.ph........hps..h-phl-D--ltphhtp........ho-c-chhhhPhclIRpAsKLGhslsG..pNsosF-pKpl+lhSPRFMSllP-cptt..sslsLLSPSlFSLHc-Go-.EpphSlsplL.tuhhsssDppsal-hllEAoGVsEsV--Ac+chhptphccpct.hhs.cGp.h.Fo+pNhocta.sscspKl-lhEpLcKoYStpQhc-MNpTGYolhsscQMphhYGctSPapNsc..hLcsY+Nho+u-hcculassI+slAccch...KFc	.............................................................................................................................................................................p.p......p.W.phh.ph.p..t.h..ppp.pp..p....................................................................ht...h-....ht......p.........................................tt.p.h..P....thlcp...............uh.ch.h..h..s..G.....ppssshs...hphlSPRhhulhP-p.......................s.phslLSPSlhuLac...c.sst.-phhsLspll.....phhp...pp-ppshlshlhEhoGlscsl-ch.ph.h......p..p........s........h.p.pp..thh...ptpphchhctLppoho.c...............Q...hpchpppGashhs.pQhphlYGptu.hpssp...................lcphpphoptp..hpptl.psI+tlAptp................................	0	39	53	113
+2284	PF04875	DUF645		Protein of unknown function, DUF645	Mifsud W, Eberhardt R, Haft D	anon	Pfam-B_4997 (release 7.6)	Family	This family includes several uncharacterised proteins from Vibrio cholerae. There is some doubt regarding the existence of these proteins, they are encoded by open reading frames contained within a repeated region in the Vibrio superintegron.	19.80	19.80	20.30	20.20	17.40	19.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.94	0.72	-4.28	12	607	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	63	0	14	247	1	51.60	66	95.40	CHANGED	lLDspHsphuFhKGCIIusIhlSLSRTLNpGQLNLDRFcFWQPTSQLLsLDVCLhDAFA	...........h.sh.ptphuFhKusIIsshhlSLSRTLNRGQLsL-RF-FWQPTSQLLsLDVCLhDAFA........................	0	13	13	14
+2285	PF04883	HK97-gp10_like	DUF646;	Bacteriophage HK97-gp10, putative tail-component	Kerrison ND	anon	Pfam-B_6160 (release 7.6)	Family	This family of proteins is found in the caudovirales.  It may be a tail component.	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.80	0.72	-3.05	172	1665	2012-10-01 19:49:39	2003-04-07 12:59:11	7	3	1229	0	221	1184	106	85.30	19	61.94	CHANGED	ccltcplpp.htp..........hpcth.ccslc.psuppl....tpphpppsP......................p............s.Gp......lpcShph...................................................ttps..st.hplpltsssp.....................Y...AphlEaG	........................................................tl.pplpp.hsp......p.hp.chh.ccslp..psuphl......hpphpppsP................................................hc........o.Gp..........Lccslph.................................t.......................ptps.....st..hs..spl...ts.sst...................................................Y....spalEhG...................................................................	0	74	152	185
+2286	PF04890	DUF648		Family of unknown function (DUF648) 	Finn RD	anon	Pfam-B_5530 (release 7.6)	Family	Family of hypothetical Chlamydia proteins.  This family may well comprise of two domains, as some members only match the N-terminus. 	26.60	26.60	27.80	26.80	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.04	0.70	-5.26	8	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	15	0	21	58	0	213.60	23	66.45	CHANGED	Mpl...YoFSP.slpsSapc+lhAsLDuYFFLGG+RhKVlolsspsshphhuppcshslSTsEKlLKILSa.LLlPIVIIALLlRhhLHppa+tph.sh.hL-st............spsl.................ph-l.tpstcsushhsh.s...........htppPpslctshhhsctpF.sshppcahhchho.....shltYllu.ppphpshsl...............cs..hp.oscshppph-hsh+scp+sl.......pcLcchLshsu..Khop.schlpptlhculpp...........sPpFh.-hscchhspLssss.Ishc.............................................tG.pssphpthtshhlhhp.....phth	....................hthSs...psoh.c+hhutLDsaFahGGcp.spllshss.tthh.hhpp...pshtl...SphEKllKI.lSa..lllPlsl...lALllRhhLH....thhphph..................................................................................................................................................................................................................................................................................................................................................................h.........................................................................................................................................................................	0	1	1	19
+2287	PF04894	DUF650		Archaeal protein of unknown function (DUF650)	Kerrison ND	anon	Pfam-B_6199 (release 7.6)	Family	This family represents the amino terminal region of an archaeal protein of unknown function.	25.00	25.00	54.00	31.10	16.90	15.20	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.65	0.70	-4.92	36	192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	147	0	121	190	40	262.30	35	66.52	CHANGED	hLCGhshCPILp+hcshpthhpphppt.....l.GuSPPSlFVGchGYP+VplsPhsPP.lpGDsu.h.a-sPppWhs..hslc-llphRsuLlputtphpVc...............pts.sthlpclQplAlSs+PV-sEhthp+h.Pphc...lhhDthhsPhGPuushcphclspNP+lP+plE+lhhD.Dh+Ac-AlhpLYcpGhslhpIp+lLSsGhLG..ccR+LVPTRWSITAVDchluchLhccl+passIsphcVahppahGNpahllLhPupasaEhlEhWhPsSlWs	.....................LCGhshCPIlt+hcshh.....ph.....h.ph...httt.....p...l.GSoPPSlFVGchGYP+VplGPhhPP..htGDsu..h..h-sPppWhs..hslc-IlphRhsLlputpp.h.pVc....................ph..sthlpclpplulSs+PVDsEltlp+h.Pp.st...lhh.sthhsPhGPpu.lcchclspNPplP+tl-+lhtD.Dl+Ap-AlhpLYpp.GhDlhpIp+hLSsGhLG..cpR+LVPTRWSITAVDchluctLhc.cl+paspls.chcVahtpahGNhahllLhPs.papaEhlEhWhstohWs...................	0	32	71	99
+2288	PF04895	DUF651		Archaeal protein of unknown function (DUF651)	Kerrison ND	anon	Pfam-B_6199 (release 7.6)	Family	This family represents the carboxy terminal region of an archaeal protein of unknown function.	20.50	20.50	20.90	21.10	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.37	0.72	-4.43	41	188	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	147	0	119	186	25	106.70	36	26.66	CHANGED	EshcG+psY.spluGuYYAARLuVhEaLpcp+RQAssllhREIpssYasPVGVW.VREsVRcAhcscP.tpF-oLc-Alphlspp..lchshppahtpSpllpth...pQpoLssF	...........EshpG+psY..spluGuYYAARLuVLEaLpph+RQAsslllRElpssYhsPlGVWplREsVRpAhc..........s...........ps.tpa-.slcpAlphlspp..Lphs..hppahppSpllpth....Qppltpa.............................	1	31	69	98
+2289	PF04910	Tcf25	DUF654;	Transcriptional repressor TCF25	Mifsud W, Eberhardt R	anon	Pfam-B_6652 (release 7.6)	Family	Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions [1].	20.10	20.10	20.10	20.30	20.00	18.60	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.07	0.70	-5.51	44	359	2012-10-11 20:00:59	2003-04-07 12:59:11	9	8	293	0	251	376	8	304.20	28	48.74	CHANGED	a..FpFp..asppYppspppFhhslphh.Dspslhpll.pphPYHlsoLLQluplhchpu.Dpshus-LlERALash-psh+ssF.....shss.ups+Lsapp.pNRtFaLsLa+alttLspRGsacTAhEasKLLLSLsPsp.DPhuhhhhIDahAL+ucpapaL....lchhp..........p.hh......pp....................................................................................................................................................................................ht..............hP...........................shuaShALAhht.............Lpcp........................................................................ppucthLppAhttaPhslhtLhc..................pl.................shs.hs...thtspss.tsh.......phhsclYltRsptlWcsspshpaLcpsht......................................ph..pt...tpshtt.....ppsht..pshshslhRallLSc......pphhshlP......pplh..tt.h.t.DP..LPP	.........................................ata...asptYppsptpFhhs.l..pth.Dsptlh....tl...L..pptPYHlsoLLQluclhchpt.-tthus-LlERAL..ashppuhps.F............phsp.GpsRLsapp.p......NR..thalsla+aht.Ltp+GshRTAhEasKLlL.SL-Pp..........DPhshhhhIDahAL+u.cpa...p.al....lchhp.............................phth...........pp.....................................................................................................................................................................................................ht....................................hP........................................Nhsa...ShsLAhhh.............lppp.............................................................................................................ppu.pthLppAhhhaPhlhh.Lhp...................ph........................................sht.hs....h.hsp.s.s....sh..........phls.plYltRst.lW.pp.sphhsaLppsh..................................................................tp.t.....t.hsh.slhRalhLo-.....hpph.h.shlP.....phh...t.....D.lPP..........................................................	0	90	142	209
+2290	PF04919	DUF655		Protein of unknown function (DUF655)	Mifsud W, Bateman A	anon	Pfam-B_6697 (release 7.6)	Family	This family includes several uncharacterised archaeal proteins. This protein appears to contain two HHH motifs.	22.20	22.20	22.20	22.30	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.05	0.71	-4.57	8	157	2012-10-03 02:11:09	2003-04-07 12:59:11	7	2	154	1	102	214	123	176.80	41	87.79	CHANGED	hE-YAaVLDYLPpGaPD-cp..a+ccPlsQulGEcpFpLLEloP+..ssDlh.....................................................................................lh-+VaIGKGp..RcKIsplsR.+lpY-DLTssA+sELPYVlE-IV+ppE-RFVcFFNcApPIosRLHsLELLPGIGKKhMWsILEERc+K.PFESFEDlcpRVculpcPs+lIscRIlcEl......csc.ppKYhlFVt	.........................................................................................................................h.EcaAhVLDaLs.....hGh.....s..s-p....+........a..p..cc.P..lsQulG-ctFpLlElssc...ssslp.....................................................................................lt-+lalGpsp..Rc+l.plt+.......+lpY--LTssA+sELshllccIVcppE.c+FVcFFNcAt..PIT...h...RLHsLELLPGIGKKhhhpIL-ERc++.PFcSFcDlccRlt....ulp.cPschlscRIlcEl..........psp..pKYhLFs.h.................................	0	27	61	83
+2291	PF04920	DUF656		Family of unknown function (DUF656) 	Finn RD	anon	Pfam-B_5777 (release 7.6)	Family	A family of hypothetical proteins from Beet necrotic yellow vein virus.	25.00	25.00	27.00	31.60	19.90	17.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.60	0.71	-4.43	2	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	4	0	0	37	0	123.70	89	45.88	CHANGED	MADsEICRCQsop.PLlphpsYDhTuRhh.cRI-IGPLGVLhNlshLFHMShlR+hDlaPaLNpIhSIsVSlDVPs.uslsssplhVhlahsp.........Wphl..C.....CasusclhSD.L	......MADGEICRCQVTDPPLIRHEDYDCTARMVQKRIEIGPLGVLLNLNMLFHMSRVRHhDVYPYLNNIMSISVSLDVPVSSGVGVGRVRVLIFTTSRERVGIFHGWQVVPGCFLNAPCYSGVDVLSDEL	0	0	0	0
+2293	PF04936	DUF658		Protein of unknown function (DUF658)	Moxon SJ	anon	Pfam-B_5062 (release 7.6)	Family	Protein of unknown function found in Lactococcus lactis bacteriophages.	22.30	22.30	22.30	23.90	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.28	0.71	-4.44	2	26	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	17	0	4	20	4	142.50	57	91.62	CHANGED	KlaDsYhpG.KhuTGThcEluchh.lS.pSluhWlKNGhssp.tNsthKhAllNc...KthME.......KhP.........G.h.hsGotpcISp....................................................Ehp-+-RRKHETKEERRLRRNIRAQMAIEsuRKE-.sh	....................KlaDsYhpG.KpuTGThcEluchatlShsSlulWlKNG+ssp+AsstYKHAI.LNcEpoKElhE.pKpEt+K.LPtuVYshYccGphlhTGTAcEISQhhpItppsVa.YlpsGKhsachhKphK+AlhNpsETRKRFPhhSh.pEcE...lEpp-K-RRKHETKEERRLRRNIRAQMAIEsuRK--.sh.....	0	4	4	4
+2294	PF04937	DUF659		Protein of unknown function (DUF 659)	Moxon SJ	anon	Pfam-B_5061 (release 7.6)	Family	Transposase-like protein with no known function.	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.77	0.71	-4.73	15	467	2009-01-15 18:05:59	2003-04-07 12:59:11	10	41	39	0	216	514	3	121.70	28	21.63	CHANGED	PohcsL+spLLpcthp-lpphl+-hKssWptTGCSIluDsWpDscu+sllsFlVsCPcGshFLKSlDsSs..hhpssphLhcLlsplV-EVGscNVVQVITcssssYtuA.GKhLhp+a..solFWoPCAu+ClclhLE-lu..K.........lcals-slccAppIT	......................................................................................h...h.t.h.....hp.....t.h....G.so...lh.sDsW..ss.....pt+.sl.h.N.hhs..s...t.u.h.h..F.hpu.l.-sos...........css...phlhphhcp.hl....c..c....l....G......p...N..VVQl...l...T...DNsss.h...htu.sph..l.tch...pl.aW..ssCssHslsLhlc-hs..p.................h..htph.ltpu..............................................	0	24	135	186
+2296	PF04939	RRS1	DUF660; 	Ribosome biogenesis regulatory protein (RRS1)	Finn RD, Moxon SJ	anon	Pfam-B_6906 (release 7.6)	Family	This family consists of several eukaryotic ribosome biogenesis regulatory (RRS1) proteins. RRS1 is a nuclear protein that is essential for the maturation of 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae [1].	25.00	25.00	30.50	26.30	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.16	0.71	-4.76	33	347	2009-09-10 22:34:59	2003-04-07 12:59:11	7	6	299	0	237	343	3	161.40	38	57.87	CHANGED	hshpaDLGpLhuhDsNsl........ssssppEptLpshsRDs...sQlLlNplhs...L.Ptcss.s-u...........sllpLPpPsohL.PREKPlP+PK.s.TKWEpFAccKGI..............pK+++s+hVaDEsos-Wss+WGYKttNc.ct-c.pWllEV............sstctstDshttpctc+Kc+lpKNchpch+Nht	...............................................hphDLGpLhuh...DsNsl...........t.tsshEp.LpshsRDs...sQhLlNplhp...L.Phpps..p-u................hlhpLPt....P....sT..........h..L...PREKPlP.cPK...s.TKWEpFAppKGI..............pKc++s+hVaDEtstcWhs+WGY..Ktt......s...ctcc..pWllEV............................tss..c....h...pD.h..scp..cpp+Kc+ltKNEhpph+Nh.h................................	0	88	139	200
+2298	PF04978	DUF664		Protein of unknown function (DUF664)	Moxon SJ	anon	Pfam-B_5281 (release 7.6)	Family	This family is commonly found in Streptomyces coelicolor and is of unknown  function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.85	0.71	-3.97	48	958	2012-10-02 14:44:17	2003-04-07 12:59:11	7	6	365	1	344	2013	90	150.30	24	84.39	CHANGED	sLtuaLctpRpslhhplcGLo-cph+ppssssus..oLhGL...........l+Hlu.pVE+sWhppshssp.sss.h..............ssssscat..hsss-ohssllutacpssspucthlu.thsLDsshsh.....tshht.....sol.RalllHhlcEhARHsGHADllREtlDG	...................................................................LhshLsttRt.sl..htpscGLoscphcp....t......s....ss..u.....s....ol.....suL..............l+.Hl...A...t...l...........E...........p....s...........W..h...t.t...s...h...t...sc....ts.h..t..h...ht........................tthst.shp.......h.s...p....s...c.....s..h...s......p...l.....l...s...t.a.pps.s...p.c.s..p..p.hl.t......t..h..s...h.-.ths.ph..s........hshtss........sol.c.hll.l.H..l.l.c.-tupH.sGp....A.D.llREhl........................................................................................................	0	134	276	327
+2300	PF05006	DUF666		Protein of unknown function (DUF666)	Moxon SJ	anon	Pfam-B_5319 (release 7.6)	Family	This family contains several uncharacterised viral proteins.	22.20	22.20	22.20	27.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.19	0.71	-4.22	25	69	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	65	0	0	67	0	150.20	43	75.16	CHANGED	FpR.sslVDC.s.po+LPCVTDpQChDNChss.hh...sshpCpp.GFCsspss.lsu.ps.s.....CDtshGLlpVasA.u-FVVsphClSsYRDllDDsGplRPYlC.......ssGsLclcLpsp.FoscDChCssGYT+hhFsQsAhuRslPVCIPNphAsLYsRlY	......FpR.sshVDCsps..+LPCVoDpQChDNCshtshh...sthsCps..GFCsspsu.hsutts...sth-CDsshGLlcVasA.u-..F.V.VsphClSTYRDll...DDsGp.RPYlC.......ssGsl....s.lsLtsp.Fo.sscCpCssGasKhlFpQTAhARolPVCIPNphuslYs+lY......................................................	1	0	0	0
+2301	PF05018	DUF667		Protein of unknown function (DUF667)	Bateman A	anon	Bateman A	Family	This family of proteins are highly conserved in eukaryotes. Some proteins in the family are annotated as transcription factors. However, there is currently no support for this in the literature.	19.70	19.70	19.80	20.20	19.20	19.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.14	0.71	-5.07	9	406	2009-01-15 18:05:59	2003-04-07 12:59:11	8	22	162	0	285	362	9	167.50	41	37.28	CHANGED	MFRssaQsG.FLolLhSsGSKPLpIWchpsKNGalKRlTDc-I+ShVLEIhGsNVuToaIssPssP.ppoLuIKLPFLVh.llKNh+KYFoFElQIlDD+ph+RRFRsSNaQSsTRVcsFhssMPhpLssG.WNQIQFNLuDFTRRAYGTNYlETlR.lQIHANsRIRRlYFsD+LYs-DElPs-a+LasPh+sp	.............................................ptaQts.Flslhhu.hG......p..........p..PlphWcp...psc.s..G.cl+...........+lhDp-lp.S..VlEI.G....sssuosaIp..sP.....t....cs.....pp.........o.........LGI+hPFLlh...llK..s..................h..p.KY...Fo..F.Elplh..DDcsl+RRFphS..Na.....p..pp....s............+l.......p......P...h.hsp.......h................P......h..p...............l........s...............p.............G....WNplQhN....Ls.DaT.......c.c..u.Yu.....o....s..Y...h..coL+....l.plpANCRlRRlYFuDplYs.pp-lP.ch.+h.......p...........................................................................	0	118	162	232
+2302	PF05003	DUF668		Protein of unknown function (DUF668)	Moxon SJ	anon	Pfam-B_4700 (release 7.6)	Family	Uncharacterised plant protein.	20.90	20.90	21.00	20.90	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.14	0.72	-3.77	18	204	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	22	0	131	194	0	88.20	43	17.08	CHANGED	TLGuAuLALHYANlIlhIE+Ll..........ss..sptlstcuRD-LYpMLPsolRsuLRu+L+shs+s............DtsLAspW+sshp+ILcWLuPhA+NhlR	.......pLGuAuLALHYANlIl.I-pll...................sp...sphls.ssRDsLYphLPsol+u.uLRu+L+shshs..................-thhssph+sshp+.hLpWLsPlApNTh+..	1	11	80	109
+2303	PF05037	DUF669		Protein of unknown function (DUF669)	Moxon SJ, Sammut SJ	anon	Pfam-B_5014 (release 7.7)	Family	Members of this family are found in various phage proteins.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.85	0.71	-4.28	22	204	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	181	0	29	185	46	130.70	19	77.97	CHANGED	hFThDasps....psapsl.sGpYcVhl..psphpsscs.Gsphlplchclhss..........papsphla.c.hh....ppcsschs.ttLpsls+AhG...h.pspphpslcsahpphhs+sl+Vslchc..sE.NGppY...plhth..scs..Ptst	...................s.pps.....pthtsl.sGpY-l..hlp..psphpsocs......G.sph...lslphplcss............ca.p.spplahphhh............pppstchshttl.thstsht...........h..ptpphpshpph.......hp.th....s+.hplhlp.p...p.pup.h...p.................t.....................................................................................................	1	15	25	28
+2305	PF05050	Methyltransf_21	DUF672;	Methyltransferase FkbM domain	Moxon SJ	anon	Pfam-B_5811 (release 7.7)	Family	This family has members from bacteria to human, and appears to be a methyltransferase.	18.30	18.10	18.30	18.10	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.82	0.71	-4.31	459	2587	2012-10-10 17:06:42	2003-04-07 12:59:11	7	106	1140	1	1157	2771	5093	161.90	17	45.41	CHANGED	DlGAsh.....G...................hhh.h......h..sshl...hs.......hEPtst...................thpthttt..........................hu.....ls...............................................t..t.hphhhhsh............t.ht.thhtst......t........ttttt....................t...............................ttphplpshsL................D..sh.hpph..............ths.....h....lKlDlEGtE...hp..lL.......s...spphl.pp...htshh...............lE.....h..................................thpplhp......hl.....pph........GYph	...........................................................................................................................................................DlGAph.......G.............................................hh...........h...tspl....hu.......................hEPtst....................hthlptp...........................hs...........ls...t.............................................................................................t..t....hphh...h..sh.t..............tth.h.....h.htt....t..shtt...........................................................ttspthplpshsL......................................................D.......sh..hpph............tpls........h...lKlDlEG....tE.....hp....lL..........pG......spphl..pp.....hpshh............h.hE......hp.......................................tt.hht...hl..........th..sa.................................................................................................	2	476	817	1040
+2306	PF05054	DUF673		Protein of unknown function (DUF673)	Moxon SJ	anon	Pfam-B_5918 (release 7.7)	Family	Family of uncharacterised viral proteins.	25.00	25.00	37.30	36.30	17.40	16.60	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.30	0.70	-5.88	23	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	0	58	0	355.70	43	99.39	CHANGED	MsCPhsI+VhISDpFlhFPYchVtsQsshus.....t.lpsLsVYVPTpEDlphls+pph..sp.FcsVhVh+Hc...sph-scsstcsssuslVYWNPIhPIsclG.lGpTpVFSVlLTssLa.Csohhlcpsssh...CPlQh....p.......................h.....phschsslsGEss..Ltphsplhcss.ssFlICFs+ETPphlKI.LNlKRlLhlhu.hRps.A+Ysl.LscpElssIapcLsWEpsRRLhKGs.hssp...C.shlNRsSLpYl+pA.-lLsIsssu.polhshlchFpsLIlsYplVP-lhlcLNslspp...........K+..VRLYC+sDShAITstGsVP.NhPssNsh.sFcasslssssh.pphppclhpcs...s.lhlpuscYNYFh	........................................................MsCP.hsI+VhISD+FhsFPYphVpPQsDlGs.....t.l.psLlVYVPT...--DlpaV-Kpth......sp..FpoVhVh+HE..ssph-ocsscKsssuTlVYWNPIlPIsElG.sGcTcVFSVLLTssLFhCpThllcppsPh.....CPIphp..........................p....hphpchhPIsGEhP..Ltchpclh-ss.ssFLIC..FshETPphlKI....LNlKRlLslhp.aRcsPA+YsIpLscpElsslYpcLsWEpsRRLh.K.......GD..hssp...C.shlNRsSLpYl+pAppLLtIscsS.polVcFVphFpsLIhPYplVP-lllKLNolcpp...........++..VRLYCKNDShAITshGsVPsNhP-pNPh..sFDaoDlsssptlpphtpclhpcs.hss.lhVpAs+YNYFh.........................	0	0	0	0
+2307	PF05056	DUF674		Protein of unknown function (DUF674)	Moxon SJ	anon	Pfam-B_5937 (release 7.7)	Family	This family is found in Arabidopsis thaliana and contains several uncharacterised proteins.	23.20	23.20	23.20	23.30	21.50	23.10	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.82	0.70	-5.86	8	313	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	19	0	190	294	0	209.90	21	83.65	CHANGED	MAcSoccPKlSLRLlIDEEKNKVVLAEAG+DFVDlLFShLTLPMGTIVRLLEcH.+KSpslsIGCFsNLY+SVV-MulDsFcT-ACKQMLLYP+Sl+cppsRsLKLNIDDTEusKhFhCPtF..pttCpchYSNFsTS+CcCGsh.........MNcEIph.cptts.uphts..DssGVFsps..+oSFlITDDLKVplsSscllLNsLKDLGhuDs.sKLsEhll-VGlcE............................VhTLLpClFTS-sPLTDTFL+K+S..o.sspRhaKt.SPslpcpt-EussDpslTLcsaVRKpD.hcILYVECGEDFVDLLFTFLAlPLESlWpISG....suIslGCIGNLhRSFKDLS...sstsppus..KCslPaYYpCQKQLL..slhTppPPsYhtah...ths...patLopp........pc+lpphhhhDPKocsphpStstp.....GFVK+sTKFhVoDDLIITPhNSsSTlslLK.chQlchDDlElQsIoIuKsE	...............................................................h...........hphhhppp..tpplhhhEuttchl-hlhs.hh.hPhuthhp..hh...................................................................................................................................................................................................................................................................................................................................................................................................................ahl.ssh..h......s........h.......th.t....h.p..h.hs...tc............................hh...h...L...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	15	106	142
+2308	PF05055	DUF677		Protein of unknown function (DUF677)	Moxon SJ	anon	Pfam-B_5920 (release 7.7)	Family	This family consists of AT14A like proteins from Arabidopsis thaliana. At14a has a small domain that has sequence similarities to integrins from fungi, insects and humans. Transcripts of At14a are found in all  Arabidopsis tissues and localises partly to the plasma membrane [1].	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.87	0.70	-5.77	7	135	2012-10-01 23:20:42	2003-04-07 12:59:11	7	4	17	0	109	163	0	266.10	27	77.09	CHANGED	L+SFDosLppRTsplIsSLsspsc.......spSls...hDuLhElsppLlEhNQsVs+lIl-.c-.DlWcNp-LhpLVpsYFcoopKTLDhCpslEpClc+Achup.LlIphAltQFEpEsh-ps.G...cp++YcKTLEEL+pFKshGsPFsG-........Fhs.FcplacpQhhhLEcLc+p+cKLDK+L+Nl.......+shRhlSNllFssAFlsVhlhSlVssuhusssssu.lAuuhssPltuhGhWss.........phWcK.EculK+p+plhpoM-tGh.ss.cshcsIphhVcpLcscIpShLcss-FAl-+cp...us+luhppIcK+l-thTcplcElG-psuppS+hIthuRhllLp+I	...........................................................................................................................................................................................................pl.tLl.pYFp.o.ps.phCttl.pslppsc.p....l..hlt.....h.....tp.................................t.h.t.hhpt.L...tpF..htsP.Fst.................ht.Fptlh.ppp.t.hlc+Lptp+++lc++l+.l.......+thp+s...Sslh..hssshs.s...lhl...sullhAs..h.s.hsslhs..hsuhhu.h.P.htsh.upahs.................phh.p.p.hpp..slp.t.t..p......phls.sh...t...tGTalhhcDh-.....oIphLVs+Lcscl-...shhphschulcp....pc...........s......lc....s.....l.c....cl+K..p.ps....Fhcpl--Lt-psthC.tsIp+ARtlVlpcI....................	0	17	65	82
+2309	PF05077	DUF678		Protein of unknown function (DUF678)	Moxon SJ	anon	Pfam-B_6127 (release 7.7)	Family	This family contains several poxvirus proteins of unknown function.	21.50	21.50	21.70	56.20	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.90	0.72	-3.99	10	55	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	35	0	75.10	63	95.94	CHANGED	hDsu...GGtKR.RKRKP+T..oVc-p.......DDCsTCSSCpSKLVplSDlTKlSLspaplsGK...usTLoCuACGSpLphLsDFs	......DST..tuGhKp.RKKKPKT..TVhD-.......DDCMTCSuCQSKLVKISDITKVSLDhlssh.+....GNTLuCuACGSSL+LLNDFA..	0	0	0	0
+2310	PF05078	DUF679		Protein of unknown function (DUF679)	Moxon SJ	anon	Pfam-B_6129 (release 7.7)	Family	This family contains several uncharacterised plant proteins.	25.00	25.00	33.00	27.10	21.20	17.60	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.20	0.71	-4.60	24	212	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	23	0	125	191	0	154.50	40	74.00	CHANGED	hsusAsLupLLPTGTVLAFQhLuPsFTNp.GpCss..sN+hLTusLlulCuhSChhhSFTDShhs..t.cG.+laYGlAT.......h+G.lhlhs...............................................................uusssspp...........chp+YRLRhlDaVHAhhSslVFhuVAhh.DtslssCaa.Pssupss.....+clLpslPlulGhluShlFhlFPosR+GIGa	.......................pusupLspLLPTGTlLsFphL..sP.hT..Np.GpCts...ss+hlousLlslCuhuChhh..oFTDSap.s.....t..cG.plaYGlAT.......h.cG.lhshs................................................................t..th...................phscY+L+hhDFlHAhhSllVFhulAhh.DtslssCaa.Ps..s.tpt.....cpllpslPlslGhlsShlFhlFPopR+GIGa...............	0	12	64	94
+2311	PF05079	DUF680		Protein of unknown function (DUF680)	Moxon SJ	anon	Pfam-B_6131 (release 7.7)	Family	This family contains several uncharacterised proteins which seem to be found exclusively in Rhizobium loti.	21.70	21.70	23.10	22.70	20.80	20.10	hmmbuild  --amino -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.92	0.72	-3.48	10	44	2009-09-11 14:48:27	2003-04-07 12:59:11	7	1	5	0	29	44	0	52.80	42	70.12	CHANGED	GSDsaGSsssNQPAAo.......stVDsotTASlcK....h.t...ossssps...psuQGs.........c.slaGp	......GSDpYGSsssNQPAAo........tlDsotTuSlcK...........ossssps............tssQGs.........chslaGp..	0	0	10	10
+2312	PF05080	DUF681		Protein of unknown function (DUF681)	Moxon SJ	anon	Pfam-B_6137 (release 7.7)	Family	This family contains several uncharacterised beak and feather disease virus proteins.	25.00	25.00	72.90	71.80	18.00	17.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.47	0.72	-3.57	2	31	2009-09-11 14:24:40	2003-04-07 12:59:11	7	1	1	0	0	31	0	88.90	84	58.80	CHANGED	MGGAChs.+YWLVPs+Vh.Rh+.T.hTu.RGVARsDGPMsSLs.NhIKCAVsGGMDMhGKhSSShTT.MGG.LIARCSA.hTVTHI+CQLRA.LWSL.ARG	..MGGACIsSRYWLsPAHVhSRh+.TSSTsHRGVARVDGPMsSLGLNIIKCAVNGGMDMMGKhSShWTTFMGGYLIARCSASATVTHIKCQLRAhLWSLPARG	0	0	0	0
+2313	PF05081	DUF682		Protein of unknown function (DUF682)	Moxon SJ	anon	Pfam-B_6152 (release 7.7)	Family	This family consists if several uncharacterised baculovirus proteins.	25.00	25.00	29.80	29.40	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.97	0.71	-4.67	16	57	2009-09-11 12:02:38	2003-04-07 12:59:11	7	1	55	0	0	51	0	147.80	46	94.26	CHANGED	p+TI.LYLsc..Pssls....sDKssDcsVlYF-GlIEslsDcSCDKhohFuELKKEcALhMKKshpDLlp+ssGNYsKNHVLlDALlMYKTYVELl..D-SAFGtslLphCh-alTthF+LFpLpS+IlVllPspssacpDNLSsLLKHLhphslIpl	..........................+TlhLYLsc..P.s.slp....sDpssDc..shlYFEuIlEClsDcoCDKhohFuELK+EpALhMKKhhpDLlp+ssGsYsKsHVLlDsLlMYKTYV-Ls..D..-SAFGpsllph.C.palTtlFcLFpLpS+IlVllP.pls.acpDNLSsLLKHLhphslIpI..	0	0	0	0
+2314	PF05082	Rop-like	DUF683;	Rop-like	Moxon SJ, Eberhardt R	anon	Pfam-B_6161 (release 7.7)	Family	This family contains several uncharacterised bacterial proteins. These proteins are found in nitrogen fixation operons so are likely to play some role in this process. They consist of two alpha helices which are joined by a four residue linker. The helices form an antiparallel bundle and cross towards their termini. They are likely to form a rod-like dimer [1]. They have structural similarity to the regulatory protein Rop, Pfam:PF01815.	21.10	21.10	21.50	27.10	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.25	0.72	-4.50	32	142	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	135	4	75	130	7	64.10	40	88.76	CHANGED	hs-.lcpLKtclKKLsu+AsphKMDLHDLuE-.LPssWppIh-lAp+Ta-sascLsph+ppLtshEsu	.......p-lcpLKtcl+KLsu+AsphKM-LHDLuE-.LPssWppIhplApcsa-AatpLspt+ppLtthct.t...............	1	17	47	60
+2315	PF05075	DUF684		Protein of unknown function (DUF684)	Moxon SJ, Pollington J	anon	Pfam-B_6081 (release 7.7)	Family	This family contains several uncharacterised proteins from Caenorhabditis elegans. The GO annotation suggests that the protein is involved in nematode larval development and has a positive regulation on growth rate.	25.00	25.00	26.20	26.00	23.20	24.30	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.22	0.70	-5.84	5	141	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	6	0	141	123	0	248.80	21	75.10	CHANGED	LcKLtELcKcIc+LS-sMsucF-DLKAFIlspEFY...................sslAsTAsTLMKaMQDTsssPsKco+cs....F+-sssKsSPLcLAcpLhphL-sEsTNPLKMAMsADsL+sccTFEKWRcIIDAVlTQhLlLEoFtNGha+D+spYcPc+LsEchcEacEphccW+E-Yps.-oSYW-ctVcshVHcIQDNNEsp..SNEEKAslI+-sL-KIMTNDtFYVlVaD.hsh....supcapasltts.c+paIuSaNRGsCNVhVaRS.....t+s+ohsppsc-L++KaQHsLss+app.....Nspahlpspu+shps+lss.CGaVtlVRsscclA...Vcsoss-.tp+GPGthh-usFctssh...hSs.csFpl	............................h.........th..ltpph..thtphc.hhst..ph.........................phh..h..lhphh.ssht..............s.p.sht....................Ftt.ht..p..Phph...............sh................h.thlp..p.oNPlhhsh.t....p....pttshppWpthhtthhsphhhlEshhtGh...tts..t.p.l.p..t..th.p.htphppta...........................................hW....pthcphlpp..h.pptt.h...sptp+AphlpptLpp.h..hoscs.F..alhVhs............t...h..................ppp.hl.s..h....p.s.t....hshhlYRS.................t.p..t....t.......t.h.tp..ht...................................................t......h......p.....t.hhhhh.t............hp.st..........tPG...............................hhh......................................................................................	0	20	31	141
+2316	PF05085	DUF685		Protein of unknown function (DUF685)	Moxon SJ	anon	Pfam-B_6261 (release 7.7)	Family	This family consists of several uncharacterised proteins from Borrelia burgdorferi (Lyme disease spirochete). There is some evidence to suggest that the proteins may be outer surface proteins.	25.00	25.00	28.80	28.80	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.87	0.70	-5.34	4	176	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	29	0	9	140	0	217.00	43	96.09	CHANGED	KLLIDEEETVQIKDLNKVTTVNNsDLLLLDDGVASSNAITFKNFL-ToKDKTFKGEGLuYFKEIIKSTIAEELAADc-FVEKIYsKIhDKLINNDSTNLSNLFSKIKSRLTDSISSATLSRSDcLLIM.SSuTIQKTPVPKQLLGlPSsashstphTcuTTlYPSDYcspuIhIsM-sauDVsLlF.KSsDDpPIYLDIDIclKHpcNc..sKuLhlpYuDETphshVYhhpGusuluhRIPhYKGWYlQKRsph.GcPVPhLlKL	......................................................................KLLIDEpETVQIKDLN+..VopVNsoDLLLLDDGsuSSsAITaKsFLcsspcchF.KGEtLsYFKpIIK.....STIApELsusp-FlcpIYsplhsKL.Ip....N....-.S....sp..lusLFpKI+SpLpsuIsp.s.TLo.cs-pLLhh..pssI.QKTslPcplhGlPssath.....t..hs..........sspla..p...Yc.........sKthhIsh......c..p....sssollh.Kp.Dsp.sIYLDI-lc..lch..p..p...st...pK.lhLpYsDEo...ppph.lYt.h.p.us..p.t....shphPhYpGWY.lQ++.t......Gt.hP.h.Kl....................	0	5	5	5
+2317	PF05092	PIF	DUF686;	Per os infectivity	Moxon SJ	anon	Pfam-B_6313 (release 7.7)	Family	This is a family of dsDNA Baculovirus proteins. It is required for the infectivity of the OBs or occlusion bodies. It is a structural protein of the ODV envelope required only in the first steps of per os larva infection, as viruses being produced in cells expressing the gene for this protein but not containing it in their genomes are able to produce successful infections. Baculoviruses are large DNA viruses that infect arthropods, mainly members of the order Lepidoptera. In their life cycle, they produce two kinds of particles, a budded, non-occluded virus (BV), which buds out of the infected cell and is responsible for the cell-to-cell transmission of the virus, and an occluded form, the occlusion body (OB), which is responsible for protecting the virus between encounters with larvae. A variable number of virions are included in the para-crystalline structure of the OB, mainly constituted by the virus-encoded polyhedrin protein; these virions are called occlusion body-derived virions or ODVs. 	25.00	25.00	37.30	35.50	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	522	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.15	0.70	-6.14	26	72	2012-10-02 15:38:38	2003-04-07 12:59:11	7	1	65	0	0	71	0	489.90	37	94.42	CHANGED	lLLlll.....lhllhphlsllphtpp..h..htslphFDNosVP........lIcPPs.EIlIEuNshpCH+pL.TPCoocuDCslCREGLAsCQhFcEpsllpls-.....ppphsIcPGESYCLALDccRARSCNPsTGsWlLscocs.GaoLLCoClpPGLVTQLNlY-DCslPVGCpPaGpIssINpsPl+CsC-sGYVuDh.ssTpTPaCRPpplRDVlh-ssFFPRsPCssGalpl-HPuLcshYRpphth..slCVhDPCSlDPIoGpRps..G+Lhhhh.sspch..hshCsC....shpcsLasVa....sssoM....lp......ps.......stplsNACI...pPFslphpplpph-hKhFWGRss.h.pSDsDlVhpVs...spl.cs+Y+thLa.hlpsH.Pphs..pss......hhllKFoluhs.....hhtpsth...tpslaphYhphstpp..sss.CF..hPGh.GcC........Isss.ssCIpR..tsh.V.osEshssshCahoRpsptl.................plWssss..hYspsphPlshhlssh...hh..hh.sspsh...pslhhlsutssssp.tph.......ssLtplLsTYPpYS	.......................................llLllllhllhpalsllpht.cp.h..h.slthFDNspVP........lIcPPs.EIlIE...uNshpCH.+pL.TPCs..THtDCsl..CRE.GLANCQhF-Epshlphp-....tppphhIp....s....GES....YCLALDRcRARSCNP.sTGsWlLs................cocs......GauLLCoChpPGLVTQLN.hY-DCsVPVGCtPaGpIssI....Np..s..PlRCsC-sG....YVuDasssTpTPaCRPpplRDVhhDssFFPR.....sPCssGalpl-HPuLsshYppphph..slCVlDPCSlDPIoGpRps..GpLhhh..ss.ct..hshCsC....shtssLasVa...ssssuM..........lpps......stplsNAClpPFssph.tlpph-YKhFWu+s..........-.h.huDsDlVhpls...spl...ptRYchhLashlt.sHPphs..t........hhlhKFSluas.....hh.t..........tslaphahthpttp..sts.CF..hPGh.GcC.........Ists.s.CIp+..t...V.suEshtsphChhoRcsptl.................phWssss..hYspsphPsshhlpsh...hh.....sspph...pslhhltstthh.t..tph........ssLtplLtTYspYS.................................................	0	0	0	0
+2318	PF05095	DUF687		Protein of unknown function (DUF687)	Moxon SJ	anon	Pfam-B_6321 (release 7.7)	Family	This family contains several uncharacterised Chlamydia proteins.	25.00	25.00	32.00	30.90	23.20	20.60	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.62	0.70	-6.14	11	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	28	0	17	48	0	453.50	30	80.94	CHANGED	csuphssss.ph..s.stslh-s..lChh.ssssppstshpVslsYlNGStpTptEA.tEuhalS-.LRGcPVRslYNsG....puhupuhhhspRsShotppPlCpAlLcsWcpFFS+stNssppallIFaGDGGsaVQpALc...pohausRIhllGIuPohYVpGpspsHaYRVsGDlsohLDppGaspup....VoTLPYSuGu-GlFhPulpsPoFpaALRht..pl.................ltp.sthsussspDpp......uusthulhlshupsssuFoRlpchLsps-osuphEhNshP.sphhDllLoulaslhRloslhQtahlhs.lshps-s.lshlhhsuYssssLphhhLhhTNppstRcpaRslRllApuhpshhhLsslh-h.....lNhhphhppss..shlpAlahsuoshosollhh-...IhchshssLRsRlQphshRhhssss.c.....pccls................RsscuuhttslshlssssuGlhhulhhGlhNthulplPcs.....lscs.ssss............NsTslas.s.h+ss.........puWpoGDshulupTlshllshllllhslhshVp.VRpNt+RR	...........s.................slhps..ls...sspsp.sts..VtVsYlNuS.pshhcu.tEshaLSp.ltGc.VhhlYNpG....phhutshh..tp...pt..pPlspAllcsWctFFup....sppFlhhaaGsuuhaVppAlp...ps.asspIhllGIsPohalp.p..s..psaaYRV.G..shhohLD.tGahtup....VspLPYSsuu.Glhh..shtsssap.Alhht..ph....................hschSs.tsssspst...........upp..ul.ls.spssssFsRl.phLs.spTs.phE.N..hP.pph.shlhpshhslhRloshhp.ahhhs.lsht.ss.l.hh.hh.ashsslp.hhLhhTs..phRcthRshRllhhshpsh..hsslh-h.....ls.hhhhtps....hhpslahhhphhshsllhh-...lhchth.sLRstl.thshRhhts.s.c......ppphp.....................pp.hsshhhhhphlpssshulhhshhhGhhs.hulplsp......hspsss...............sposhhs.................sa.sscshulupshphhhshlhhhh.lh.hlt.lptp............	0	3	3	17
+2319	PF05093	CIAPIN1	DUF689; 	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis	Moxon SJ, Bateman A,	anon	Pfam-B_6320 (release 7.7), Wood V	Family	Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [1].  CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis [2]. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress [3].	21.70	21.70	25.50	22.90	21.60	18.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.47	0.72	-10.97	0.72	-3.92	25	368	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	289	0	251	368	1	85.80	45	31.98	CHANGED	sDhcps..hs.tt..Cs.s......tK++KACKsCTCGLAEtpEpEppsppspppp........................................................t.........phps.t..SSCGsChLGDAFRCuuCPYLG...LPAFK..PGEcVpL	...................................................................................................................t...t..Ctss.....tp+++A..CKsCTCGLAEp.ctcppttptttt...................................................................p..uuCGsChLGDAFRCuuCPYl.G...hPAFK..PGEclth............	0	93	143	211
+2320	PF05148	Methyltransf_8	DUF691; Methyltransf_hyp; 	Hypothetical methyltransferase	Moxon SJ	anon	Pfam-B_6432 (release 7.7)	Family	This family consists of several uncharacterised eukaryotic proteins which  are related to methyltransferases Pfam:PF01209.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.42	0.70	-4.71	4	358	2012-10-10 17:06:42	2003-04-07 12:59:11	10	15	292	2	259	3274	773	201.90	38	54.17	CHANGED	sLpt+hpcRLDGu+FRaLNEpLYospuscAhchFpEsPphFcLYHcGFp.QVcKWP.pPlDhIIccL+........p+.sshVlADlGCGEA+IA...thpc..pV+SFDLsulsc+VhsCDM.uplPh-DpSVDlAVaCLSLMGTNltsFl+EApRlLKsGGlLhlAEVpSRFs..SlchFt+tlsKLGF-hpphclpNshFhLF-FpKss..hhu.Kc.h.slpLpPClYK+R	...........................................................................................................................s.L.tphtt+LtuuRF.RalNEpLYTpsSpp.Ah.phFppsP.p............h.F.p......Y....Hp.Ga..pp...Q..V..p.....p....W.P.....N.P..V....D.h..h....lp...l+................................................................p.p...s..t...p...h...s..l..A.Dh..GC...G............-.......A....p....L.A....................ps.h......p........p...........p..............................V...............a.......S.......F........D..............L..............h..............u................s...............s.................s............h..............l.............s...............s...............s..............D..............h.......u...............p...............l..............P.....L.............t..........s.......pS.......lD....l.....s.....l....F.....C.....L...S......L.....M.......G.......T.....N....a....h.......s....F......l.c...EAh.R...lL.+..st..G...........L..h.....l........A........E.................l...p....S......R.Fs...................s.s.p...t.....F....h...p..h..l..p......h....G....F...h.............t...........p.hFhh...h.h...+.................................................................................................................................................................................	0	97	153	220
+2321	PF05114	DUF692		Protein of unknown function (DUF692)	Moxon SJ	anon	Pfam-B_6476 (release 7.7)	Family	This family consists of several uncharacterised bacterial proteins.	25.00	25.00	26.90	26.90	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.63	0.70	-5.49	7	833	2012-10-03 05:58:16	2003-04-07 12:59:11	8	2	668	1	283	808	137	271.00	36	91.05	CHANGED	hhpuAGLGhRpslhcshlsh.pssslpFlEssPENahshGGhhhtph-pltER.hPlshHGlSLSLGGtsslDhshLcslKthhcpacshhhSEHLuaspscG.pLa........DLLPlPaT--Alc+lstplR.sQDhLtp.lhlENsShYlp.s.pphsEl-FLpAlspcssCtLLLDVNNlaVNAsN+Gh.DPhtaLsslPscRlshlHlAGHspp..u......................spLhIDTHGtsVtssVWsLLttAhuRhus..PTLLERD.NhPPhuELhAEl-pItth.p+uttAtt	....................................................................................h...tsGlGhRtphhpthh.p.......................t...s.........sl.s....ahEltsEN..a......h......s...................G..G...h.......h..t.....ptL..cpl.t-..c..aPlshHG.l...u.L.Sl..Gu....s..s...PLD....tsa....L.p.pl+phhcphpsshhSEH..Lua...s...p....s.....s.....G...a.ha..................DL......LPl...Pa.Tc.Eul.cplsp.+lcpVQ-hL..t.c...lhlENsS.......t..Ylp......h.....s......t....u..phsEs.....-Flstlsccss..CtLLLDVNNlYVsuhN.H..........Gh.....D.........s.....t.........s....a....L....ssl....P.hc+Vs.lHlAGHs...pp......t........................ss....l.lID.THup..sV..ss..sV...WsLhpt...........sht..p.h............G.....s.....hP.TL.l..EhD.tslPs.hstL...hsEh...pphpph.t......tt..................................	0	73	162	234
+2322	PF05113	DUF693		Protein of unknown function (DUF693)	Moxon SJ	anon	Pfam-B_6473 (release 7.7)	Family	This family consists of several uncharacterised proteins from Borrelia  burgdorferi (Lyme disease spirochete).	25.00	25.00	29.80	25.00	18.00	17.60	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.08	0.70	-5.50	2	142	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	27	0	14	124	0	282.70	62	98.41	CHANGED	hlLLpYDFKIEFYcscpS..KcoosG.sh.EETPKIIINTQHGIHlDIoISN.aSNhphlpSKpsKIVLWNLPLDFsscIchGDIVKIaYKKFAHEKpFDFIMAGhLGTPMSTDYPGGDFSVELDVRLhspSNFFNRKL...EsKsFKGKTVQEAIESVFPNRNIIpMDccDRLKlI-KsIYATTPKEFlDKIKGlYlHsVIADlGss.hss-CNhIFTN.+phtus.pYcALEDYGLEFIPQQEIsltspaKIphlaWNApTFYTHKLplGDKVSFIDGLGKMIKTTIKETSApLSNsGECSLILKLcDDSscpc	...............MLLLQYDFKIEFYss..c..pS..Kco.sG.shsEEhPKIIINTQcGI.H.lDIoISNha.S.shNhlpSKpuKlVLWNLPLDFTccIchGDIVKIYYKKFAHEKs..FDFIMAGhLGsPMSTDYPGGDFSVELDVRLhopSNFFsRKL.........EsK...NFKGKTVQEAIESVFPNRNIlNMDEcD+LKII-KsIYAoTPKEFI-K.I.K.GhYlHsVIsDlG....s........s........shslECpaIFTNhtphtts..pYcALEDYGLEFIPQQEIsltsphK.h.phlaWNApsFaTHKL+lGDKVSFIDGLGKhIKsTIKETSARLSNsGECSLILKLhDDSs...........	0	7	7	7
+2323	PF05107	DUF694		Family of unknown function (DUF694) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of hypothetical bacterial proteins.	25.10	25.10	25.90	33.40	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.76	0.70	-5.17	68	568	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	510	0	201	554	13	266.70	31	92.36	CHANGED	lpNRh-FlhlaDVpsuNPNGDP.sG.NhPRh.D.ETGpGlVoDVsLKRKlRsalpt..........p.........................G....p......pIaVpcpshhp.............................................ppptphhsth...........................................ph......pt..t.t.............................tttscphtphhCppahDVRsFGAVhu..........................thssuplRGPVQhs.aApSlcPl..l.hphsIT+hssop.......t......-uc...cpus.....................................tpMG.cKahVP.YuLYthaGhlsspL.A..cc....TGFo--......DlcllhcALhshF-pDp.SuuR..GpMpsRtLlhacH........sst....lGshsuttl.................acp....lplsh..............pp.psscsap..Dh.pl	..........lpp+h-Flhla-VpsuNPNGDPssu.NhPRh.Ds-pGhGhloDVsLKRKlRshlp..t.........................G....h....pIa..lpppthhs.....................................................................pp..p.phhpth...............................................................phttt.h.t......................................ttptcchtphh..sp...p...ahDlRsFGAVhs.......................s.....thssupl+GPVQls.hupS..l.cPl..h..phsIT+ssssp...............p-sc..cpps............................................pMG.pKahVs.YulYthpGhlssph...A..cc..........TGFo--......DlphlhcALhphF.-pDp...SuAR..Gphps+tllhacH...........sst............LGshsuthl......................act.........lplph...................pt.p..p.ht-..............................................................	0	87	152	181
+2324	PF05117	DUF695		Family of unknown function (DUF695) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of uncharacterised bacterial proteins.	22.40	22.40	22.40	22.70	22.30	22.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.53	0.71	-4.25	13	259	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	238	0	50	209	9	131.20	24	51.99	CHANGED	hppsWpsYhoplsD+.AhhohNlulhcphss..phhspllplplsappssEsGLPss-EatcLtch.s+l.splsAhs.slasG+lhssGptchaFYspps....sslh-sLsph.sashshshQ-DscWDhYFcFLh	..............................................................................ppWt.a.sh..l.s.sp.us.hplNlsh.hph.t.h..pphsphlplplt.apsssEsGhPot-EhppLtplE-plhp.pl....p.shs...slhsGplossGp.tcha.FYsccs....th.phltcsL.....p.p.h....c.h.th..p..h.thpcD.pW...chYhpaLh............................	0	16	33	43
+2325	PF05128	DUF697		Domain of unknown function (DUF697) 	TIGRFAMs, Finn RD, Bateman A	anon	TIGRFAMs (release 2.0);	Domain	Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	20.20	20.20	20.30	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.61	0.71	-4.75	81	1824	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	1554	0	346	1241	405	156.70	29	46.24	CHANGED	hpspclhphhcphlhp.p-ppAcpllp+huhtsAsllAloPlsllDllhsshtNhpMlpcluclYGhchuhhuthcLh+plhtsluhhGssclussl....ltshLuh........slsuhluu+hsQGlssGhLTttlGhushchhRshs.......assts...lspllpclhpthcc	........................................stclht.htp.l.....hctpAcp.lp+hAttuuh....h...lA....lSPlsllDhshlshtshclIpcluplYGl-huh..h.u..t..h..c.......Lh.+.h.l..l..h.s.hA..h.sG.....u...s.c..l..sc..cl..........shshh.u......................slsu+l..o...spsuQGluAG...hl...Tt...tlG...h.tu.h....c.hhcshs............a.ttp...tltph.hpphht....p.............................................................................	1	76	196	287
+2326	PF01901	DUF70		Protein of unknown function  DUF70	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Archaebacterial proteins of unknown function. Members of this family may be transmembrane proteins. 	24.20	24.20	25.00	25.00	23.60	24.10	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.18	0.70	-5.39	16	72	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	43	0	46	76	4	303.90	22	86.25	CHANGED	.hhhllllhlalsluhl................phhhshllhhhuhhash....shlsuphlht.ht..........h.....................chphptpcphshhlllIGllhhhhsllhlGuIPLhcshlRtpLsshhhhhsaLhhlususllhu...phpchthhlhsh.............hLlsLhGYRTsVlsllluhhlhhYYsp+ls..t+tlllshlslhl.lLuluhhphhs.thts.s......lhhRhthThsVL-hIl...shsGshpGclphssl............GPRslIuphlh.shu..VoITsTlFGshhLDFGlhulhl.hhlLGlhhGlha+lspph.+ulYhhhYSlLluYsllGIETGhLDlslhlhYlhuhIlthh	............................................hhhhhlhhhalhh..h..................................hh.hhhlhhhhshhhhh......hhh.sphhht.h................................................hphhhppphhhhhhhlGll.hhh.lhhhtulPLhs.slRhtlss.....shlhhl.uhuhllhu............phpppthhlh.h..............hllsLhGY.Rosll..sllluhllhhYhp.p+lp......h+..llhhh....hhhhl.hlulshhthhh.t.tt..........lh.RhthTh.lhchll.......sh.uhhhGplhhss................sPRthI...........uphlh.hhs..hslTsTlhGshhhDFGhhGl.l.hhllGhhhthhhchtp.h..ptlYhhhhullhuhhhlulcoGhLsl.lhhhahhuhl...........................................	0	9	15	31
+2327	PF05142	DUF702		Domain of unknown function (DUF702) 	Finn RD, Sammut SJ	anon	manual	Family	Members of this family are found in various putative zinc finger proteins.	20.50	20.50	20.80	21.40	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.08	0.71	-4.05	16	166	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	27	0	104	156	0	135.60	46	49.80	CHANGED	utuGs.hsCQDCGNQAKKDCsHhRCRTCCKSRGFcCsTHVKSTWVPAA+RRER.Qpthuu.ttt.stt.........ssussc+.Rp.........sttoohssophssusss.thsspp....................aPsEVSSsAVFRCVRVoulDD.u-sE.aAYQTsVsIGGHlFKGILYDQGs-pp	...............s..sshsCQDCGN.QAKKDCsahRCRTCCKSRG....Fc....CsTHVKST.WVPAu+RRER.Qt.hsshttt...................ttsss++.+...............t.t.t...sshsp...sphsss...p.....t.h.th.t.p.............................hPtpVpu.AlF+CVRVoul--..u......-sE..hAYQssVpIuGHlFKGhLYDpGsc..t...........................................................................................	0	16	70	85
+2329	PF05152	DUF705		Protein of unknown function (DUF705)	Moxon SJ	anon	Pfam-B_6448 (release 7.7)	Family	This family contains several uncharacterised Baculovirus proteins. 	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.96	0.70	-5.44	27	75	2012-10-03 04:19:28	2003-04-07 12:59:11	7	1	73	0	1	97	1	256.70	34	92.37	CHANGED	hpWhsL+p+pu.hl+cHlLhlscasDLphl....uacplchhEaVlFthssp...........pphssppYthplhps.pDsMp-lRpplKpsaKsshLGHsaVlpc+.shYsh..LcEWhV...shh-V.p.ht.pshhachPH...VlVFDLDSTLIT-EcpVpIRDptVY-SLp-L+ptsCVLlLWSYGsREHVscSLpcscLs.sYFDlIlstGppssphsss............hhsDpphchhahspsFahD......hsstps.....LPKSPRVVLaYLpcpGlNahKoITLVDDLhsNsauYDhFVpVp+CP....PlsDWphYH-pIlcNIpcY-shap	.........................................................................................................................WhsLc.pts.hh+tHlLhlsphtDlhhl....thpthphhEallhths.p.............hs..pYhhphhps.tDsMp-hRhplKhsa+hshLGHhhllt.pc.shYsh..LpEWhl...sh.pl.p..ht.pphhaphPH...VlVFDLDsTLIT-E.p.pVpIRDstVY-SLp-L+ppGC...lLlLWSYGs+-HVscShccs..c..L..s....sa.FDllls..tGpphtp.ttt.............hhD..p..chhahppsFhhD..........hp.tpt........lPKSP+lVlhYLpchslNahKolTLVDDL.sNsasYD.aVplp+C.....PhpDWphaHp.Ilp.l.pY-t................................................................	0	1	1	1
+2330	PF05153	DUF706		Family of unknown function (DUF706) 	Finn RD	anon	Pfam-B_2804 (release 7.7)	Family	Family of uncharacterised eukaryotic function.  Some members have a described putative function, but a common theme is not evident.	20.60	20.60	20.70	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.86	0.70	-5.05	21	371	2012-10-01 20:28:14	2003-04-07 12:59:11	10	7	259	4	239	388	200	228.40	49	78.66	CHANGED	Yssu..p-RV+pFY+ppHp+QTVsashptRtcat..phs+tcMolWEAlEhLNsLVDESDPDs-lsQIpHhLQTAEAIR+D.sc...-WhpLTGLIHDLGKlLhh..F...u-sQWsVVGDTFPVGCpFs-phla.s-oFcsNPDhssPhYsT+hGlYp.sCGL-NVhMSWGHDEYhYpVhK.spSTLPccuLhMIRYHSFYPWH+cGAYpHLhN-cDcchLchV+tFN.YDLYSKScchsDlEpLKPYY.pLI-KYFPs...hlcW	.........................................................p-pVcphY+..HppQTlsashp.t+tpat........p.h.s..+.tcMolaEAh-..hLss..Ll..DE...SDPDs...-hspIpHhlQTAEuIR+D.sc...cWhpLsGLIH.....DLGKlLhh.........a.................up..........s..........QW....sVVGDTFPVGCta.sc.....plla...chF.........p.s.NPDhps..shY..sTchGlYp.sCGL-NVhhSWGHDEYhYpV...............hK..s.p.o.oLPppuLhhIRYHSFYPWHp....tG....s.YpcLhs-cDh.ch...LchVptFN..a...DLYSKs.s.p.h....s.....cl..-pL+.PYY.pLI-ca.hPt...hlpW.................................................	1	72	137	192
+2331	PF05212	DUF707		Protein of unknown function (DUF707)	Moxon SJ	anon	Pfam-B_6598 (release 7.7)	Family	This family consists of several uncharacterised proteins from Arabidopsis thaliana.	24.10	24.10	24.70	24.70	23.40	24.00	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.10	0.70	-5.30	9	266	2009-01-15 18:05:59	2003-04-07 12:59:11	7	11	48	0	153	263	5	249.30	42	72.25	CHANGED	hassopP+GAEhLPPGIVss-SDhaLRRLWGpPp..EDlspps+YLlshTVGasQKsNlsusV+KF.S-sFsIlLFHYDGRsotW.--hEWS+pAIHlSs+KQTKWWaAKRFLHPDIVA.Y-YIFlWDEDLGV-pFsAEEYl+llKKaGLEISQPGL-sspG..lsaphTtRRsct.EVH+....................shFVElMAPVFSR-AWRCVWHMI...............QNDLVHGWGLDFsLt+CV.......-sscEKIGVVDSQallHpulPSLGs...................QGpucputushpuVRsRsptEhphFpsRhusAEKph	........................................................................h.............LP.GIl..posh.h+..L.as.sp..............pph........t..p.LlshsVGhpQ....+t.lsthV....pKF...s...............p......sFslhLFHYDGpsstW.pph-WSpp...AI.Hlustp..QTKW.....WaA.KRFL..HP..DlVu.Y-YIFlWDEDLsV..-pFssc....c.....Ylcll+ccGLEISQPuL-sspu...lpaphT..hRp...t.......s........t..clH+....................tt.....t....th.s.t.t....sphPPCsu..........aVEh.MAPV.FSRsAW.+ClWH.hI...............Q.NDLlHGWGLDatLthCs......................tstpc+lGVVDupallHp.s.l..PoLGs..............................ps..ps.t.....p.s...hs.....h....tlRtpshhEhthFppRhtpA.t...........................................	0	28	91	123
+2332	PF05166	YcgL	DUF709; 	YcgL domain	Finn RD, Bateman A	anon	COG3100	Domain	This family of proteins formerly called DUF709 includes the E. coli gene ycgL. Homologues of YcgL are found in gammaproteobacteria. The structure of this protein shows a novel alpha/beta/alpha sandwich structure [1].	25.00	25.00	26.10	25.40	22.00	18.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.32	0.72	-3.85	61	977	2009-09-11 13:36:28	2003-04-07 12:59:11	8	2	970	1	147	486	68	71.60	58	75.14	CHANGED	CulYKSsKKsshYLYVt+..........+DsFscVPEsLhphFGpPphVMhlsLssc+pLApsDsccVhpslpppGFYLQhPPs	......CsIY+SsK+-pTYLYVcK...........+DDFS+VPEtLhcuFGp.PQhuMh.L.sL-GRK+LssADlEKVKpALsE..QGaYLQLPPP..........	0	27	60	108
+2333	PF01902	ATP_bind_4	DUF71; ATP_bind4;	ATP-binding region	Enright A, Ouzounis C, Bateman A, Yeats C	anon	Enright A	Family	This family of proteins probably binds ATP. This domain is about 200 amino acids long with a strongly conserved motif SGGKD at the N terminus.In some members of this family e.g. Swiss:Q12429, this domain is associated with Pfam:PF01042. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.19	0.70	-4.98	6	870	2012-10-02 18:00:56	2003-04-07 12:59:11	12	20	725	8	474	928	144	206.10	27	57.01	CHANGED	hKsAsLaSGGKDSshALYhAhcc.hEVcaLVslho-Nc-.SaMaHssNlclscl.AEulGIPllchhspG.cEcEV--LtshlcpLc...V-ullsGulhScYQKpRI-pVCRElGlKshsPLWc+sP.chh.EhlctGFcshllAVsAhGLscsWLGRclc+chlD-LpcLsE+YGIc.AGEGGEFETlVLDuPlF+tRlElcph-thWctphGahtIc+tcl	............................................................................hh..hSGGKDS...shs.h......hp..h.hpt.....sh.p...l...h.....h...L.........h.s..........h.......h........s............c.....t................c......Shhap.....shs.h.p..hlph.A....c.uh.s....l.....P..L............h...........t....h............t...........h..........p............s...............................p..............p..................c....................h..c...s..l....h.p...h....L....p....p...lp........................lc..u...l...shGsl.....h.s.....p.h.....p..+s.hh.-pl.................spc..l..G.Lpsh.hPLW...........p................c...............s......p...........p...p..........Llp...-h......l...........s..........t...............Ghcs.hl..lpVs.u..h..G.L......s.t.p.a......L..........G+......p..l...s..............p.....h.....h.t.p..L.hp..h........................s....l......c........ss........GEsGEacTh..VlDu..P..lF....c.p.p.l...ltt..p...h.....................................h......................................................	1	171	291	398
+2334	PF05164	ZapA	DUF710; 	Cell division protein ZapA	Finn RD, Mistry J	anon	COG3027	Family	ZapA is a cell division protein which interacts with FtsZ.  FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related proteins early in the bacterial cell cycle.  The interaction of FtsZ with ZapA drives its polymerisation and promotes FtsZ filament bundling thereby contributing to the spatio-temporal tuning of the Z-ring [1][2].	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.79	0.72	-4.02	162	2881	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	2807	8	629	1565	1385	96.40	23	86.52	CHANGED	plp....l.pIhG+pYplsssssp-ctLppsAphlcp+hp.clppp..ss.thssp+lhlh..uALsl.......uc-hh.......p....tcppt....tphpp....................................................................phppc......lcpLt............................ppl-	...........lslpIhGcsaplsh.s.s.-.........p...cct.L..ppsAchlsp+lp..-l+pp......st...shs...spc.l.....sll..sALNl.......spEhh...........p.......hcpct......pphtp..................................................................phppp.lp.ltt.....................................................................................................................................................................................................................................................................................................................................	0	210	399	517
+2335	PF05167	DUF711		Uncharacterised ACR (DUF711)	Bateman A	anon	COG2848	Family	The proteins in this family are functionally uncharacterised. The proteins are around 450 amino acids long. It is likely that this family represents a group of glycerol-3-phosphate dehydrogenases.	25.00	25.00	28.30	28.20	23.80	22.70	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.23	0.70	-5.76	53	1207	2012-10-01 23:28:04	2003-04-07 12:59:11	7	3	1155	2	247	890	31	418.00	60	95.97	CHANGED	M..p.ppIhETlpMlppcpLDIRTlThGIoLhDChssshp.htpplapKIs.phApsLVcsuccl....ppcaGIPIlNKRIoVTPIullut.uhtt.psh......lphAcsLDcAAcclGVsaIG.GaSALVpKGhopuDctLIpSlP-ALssTc+VCuSVNluoT+sGINMDAVpphGclIKchAphost..uhusAKLVVFsNusp.....DNPFMAGAFHGlGEs-sVINVGVSGPGVVcpAlcch..c.ut....s.............hptlu-.pIK+TAFKlTRhGpLVGppsuc+LsV...sFGlVDLSLAPTPshGDSVAcILEphGLppsGs.GTTAALALLNDAVKKGGhMAsopVGGLSGAFIPVSEDssMlcAlppGsLsl-KLEAMTuVCSVGLDMIAlP.GDTsscTIuulIADEsAIGhlNsKTTAVRlIPssG+csGD.V-FGGLLGpu.slh.lsphsuttFlp	.........................................................................hphpplhETlpMIccpphDlRTITMGISLLDClc....sDhpcssc+I.YpKIT.opApsLVtsG-cI....tsEh..GIPIVNKRlSVTPIulluu.As.ps...sDa...................VslA+sLD+AAK...clGVsFIG.GaSALVpKGh.ppuDchLIpS.IPcALupT.-hVC.S.S.VNlGST+.....uG.I.NMsA.VppMGcl...IKcsAchos.................hGsAKLVVFs..N.A.V.E.....DNPF.MAGAF........H....G....VGE..uDsl...INVGVSGPGVVKcALEcl.....+Gp...s................a-hlAE..Tl.K.K.T.AFKI.TR.hGQLVGp...AScRLGV......sFGIVDLSLAPT..PAlGD..SVAclLEEMG.L..E......plGoHGTTAALALLNDtVKKGGlMAsspVGGLSGAFIPVSEDpGMIs....AVpsGsLsLEKLEAMTulCSVGLDMIAIP.GDTsAc..........TIuuhIADEAAIGhINpKTTAVRlIPs.GpcsGDhlEFGGLLGhA.PlM.VsthSs.sFl.s.......................................	0	100	167	212
+2336	PF05168	HEPN	DUF712; 	HEPN domain	Bateman A	anon	COG2250	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.33	0.71	-4.21	92	1339	2012-10-01 22:14:54	2003-04-07 12:59:11	9	14	572	11	648	1274	106	115.30	18	27.05	CHANGED	hcthlcpAccsLcsAch.hc.ps..hYshusFtupQAsEhslKAlLhp..hstp..s+sHsltpLlp..hlpphh........spphhcth.......phLpphhhtuRYsshh...........scc-AccslptAcp....llch.h......cth	.......................................................hhppAppplptAc..h.....h....p...ps........ha.p......h..u.s..ap.sppu....sEpslKA...h...l...ht.............hsh....p........s........p.....s....H.s.l.t..t.Lhp......hlpph..................pph.tp.th..............phLpph..h..h...t...s..R..Ysshh......................spppsp.phlphspp....lhph.h...h....................................................................................................................................................................................................................................	0	263	417	547
+2337	PF05206	TRM13	DUF715; 	Methyltransferase TRM13	Wood V, Bateman A	anon	Pfam-B_10143 (release 7.7)	Family	This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4 [1].  TRM13 shows no sequence similarity to other known methyltransferases.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.98	0.70	-5.14	29	265	2012-10-10 17:06:42	2003-04-07 12:59:11	9	15	192	0	183	340	36	237.10	27	56.06	CHANGED	hQQuSllGphcchph...L........ssss.....................salEFGAG+GcLSpalsp..sh.pp..............................stspalLlDRsspRh..KhDs+lppcp...................hlpRl+IDIcDLsLstl.p.................t...ptpth.......luluKHLCGsATD..LoL+Cllssshtpt....................................tsp..htGllIAhCCHHhCsacpass.........+ca.ltphGhs.pp.-Fphlp+hsSWAVsGpc.............................................t..tp..ttlshp-RcplGhhsKRlIDtGRlhalcpp.....Ga.pspLhhYsppslohENVsLluh	..........................................................................................QpuS.llt.hpp.thl........t.tp.........................salEFGAG+G.t...Lothls..sh.t....................................................................ttsphlL.l..-R.ts..Rh...K.hDtp....hp.ppt.............................................hpRlphDIpc..Ls.Lstl..........................................................................................t....tt..h..................lsluKHLCGsATD..hsL+Clhps.h.........................................................................................htulslAhCCH...HhC..pappass..........ppa..h..p..t.huhs.....tt.pFthhpphsS.WAssu.t.........................................................................................t....hs......tc+.......ptlGhhs+tllD.GRl.aLppp.............sh..pstLh.Ys..p..lo.ENhhlhs.h...............................................................................................	0	75	106	154
+2338	PF01904	DUF72		Protein of unknown function DUF72	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this family is unknown.	20.80	20.80	21.30	21.10	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.87	0.70	-4.61	218	2485	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	2050	4	731	1925	168	236.10	27	85.81	CHANGED	hYPpshsp.tp.pLp..hYupp..assVElNuoFYs.h.s.p........shtpW.tpp....sP..c.s.FpFslKss+hlT.H...t...ppLp...............................sspsh.ppF.....hp.slpsL...t..s+...LGslLhQhPP..s..hphsspphptlhphlsph...............................s........hphAlEhRHto.ah........s..th.hphLc.c....tslshlhsDsst......hs.hs.................hss............shsYlR..hHGpsth.................h.htYss......ptL...ptaupclt.t..htt...u......................cc.salaFsN.stp.s...pAstsAhpLtchl	.............................t..tp.pLptYupp..FssVElNsoa.......Yu.h.p..c.........sht+W..tp.p....oP....-..s...FcFshKhspslT..H.......p.ttlp...............................................pspct.l...ppF.....hp....tltPL...........t......s+..lG.llhQh...Ps.......s.......hths....s.cpl.stLh.phhpphs.....................................s.....h.shuVEhRH.s.aa......p..pph.hphLc.p....ps..ls.tll....sDptt.....sh.s..ht...............................................................ss........................shshlR..hpGpspht....................h..tYsp................ptl.....ptasp.+lt.p....htp....ts........................ppsalhhps.sstu....pAspsAtpLhp................................................................	1	225	443	602
+2339	PF01905	DevR	DUF73;	CRISPR-associated negative auto-regulator DevR/Csa2	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats [2]. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation [3]. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers [4]. This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system [2].	22.70	18.80	23.30	19.50	22.60	18.70	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.54	0.70	-5.55	28	278	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	233	4	129	276	8	245.00	21	77.26	CHANGED	lsuRhhlpscuLNtsEusG.NhscpR+ssll.hppt.......aplthVPslSGpultHtattsLsclutpp...shslschscph...thhhphsstp.h..............t..thEpphlppsslpDltGFLh...........s.tsps.............l+RsSslphoahlPs.cthp.......h-sthHsRas................ttppppQslaphEtuSulYshohslDlstIGhsps.................................................................p.phslpsc-+.pcRlcsulcALh.hLsth.hGA+psRhhPlht..phVsuloc.tPhss.s..sth.scYl-psh	................................................................................h..hph.hphpuhNh...s-.u.....h.....G.....Nhsph++l.................hpsp.hshlStpul+athhptlt.c.hh.t.......p........h....t...t........tthhpht.......................................................................................................ppsslpphhptDlaGaMp.......................................stpsts..................hpRsSsl+lo.hlulpsht..............h-hpF..tsphs......................................t......ttp..ss.slaphEhp.p.uhYphohslDLcplGh..s.pt.............................................................................t.htl..spc.E+..tcRlpthlculth.hst.s.htu.+.hspht..Phh....hlhsh.p.......................h........................................................................	1	58	86	103
+2340	PF01906	YbjQ_1	DUF74;	Putative heavy-metal-binding	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerises as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	22.40	22.40	22.40	22.50	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.20	0.72	-3.61	171	2580	2012-10-01 20:55:33	2003-04-07 12:59:11	12	6	1979	20	541	1427	512	98.20	39	85.64	CHANGED	MlloTTssl.tG+cIhchhGlVtG..psltup...slh+DlhAul+sllG...GchpsYp.chLpcARcpAlpchtpcApplGAsAVlulch-hssl......sp..uhh..lhAhGTAVpl	.............................................................MhhoTTssl.tGppIhchhGl.VtGpslhut......Nlh+DhhAu..l+.sl.lG............Gc...suY...p.c.Lp......cARc.AhpchtppActhGAsAlVGlchDhpsl...........up.....uM.l.....Vss.GTAVp....................	0	198	364	467
+2342	PF01910	DUF77		Domain of unknown function DUF77	Enright A, Ouzounis C, Cerutti L	anon	Enright A	Domain	Domain of unknown function.  The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is  likely to exists as at least homodimers.  Sulphate ions are  are located at the dimer interfaces, which are thought to confer additional stability.  Although the function of this domain remains to be identified, its structure suggests a role in  protein-protein interactions possibly regulated by the binding of small-molecule ligands [1].	24.90	24.90	25.10	24.90	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.81	0.72	-4.31	104	1948	2012-10-01 20:40:01	2003-04-07 12:59:11	12	3	1567	27	505	1121	132	91.30	29	87.80	CHANGED	sslsllPlG..s.....ssSlupaVApshcll....ccuG.lpaplssMuTsIEG-.hDclhpllccsa-tshptGusRVhoslKlDpRpD.pp.tsh...ccKlpsVc	.....................hslsll..Phu...st.......sssVsphV.scslcll....p.p..uG....lp.a............plsshtTsl........EG-.hc-lhcllppspEhshp.t.tssRVhoslKl..chR.sp...hsh....ppKlpph............................	0	171	325	444
+2343	PF01918	Alba	DUF78; 	Alba	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.	21.40	21.40	21.60	21.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.03	0.72	-4.38	126	745	2012-10-03 06:24:24	2003-04-07 12:59:11	16	6	348	31	496	820	75	66.30	25	38.49	CHANGED	splhVss.tpshhshlptshphl....................................................pps...tcpVhlpuhG.pAIs+AlsluEhl+pch.......s.hp.lpplshss	.............................................plhlss.tp.ltsalthshphh.........................................................pps...tccVhlpAhG.pAIs+sVslAEllKc+h..........shhp.hpplp...h.........................	0	148	273	408
+2345	PF01923	Cob_adeno_trans	DUF80;	Cobalamin adenosyltransferase	Moxon SJ	anon	Enright A	Domain	Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation [1].The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12 [2].	21.30	21.30	21.30	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.92	0.71	-4.45	180	2946	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	2347	41	715	2068	1103	162.40	34	75.35	CHANGED	IYT+TGDpGpT...uLhsGp...RVsKsc.RlcuhGslDELNohlGlsh..sth..............................pplpph..LpplQpcLFclGu-LAs..s.....t............hcls.pp.plptL......EppIDphstp..lssLcpFlLPGG.......stsuAtLHlARTlsRRAERthVsL.....tppps......l.ssts....lpYLNRLSDhLFlhARhhs	.........................lYT+TGDpGpT...sL...h...sup...RVsKsc..Rlpu...hGslDEhNuhlGhsh.sth...............................tpphpth.......LtpIQppL.Fsl.u.u-Lus....st.................................htls..pp..plptL................................Eptl..D.chstp...hs..s...L..cp..FlLPGG........stsuAhLHlsRTls..........RRAERthspl.....................tppps.............l..pstl..............lpYlNRLSDhlFlhuRhh.................................................................................	1	266	472	598
+2346	PF01925	TauE	DUF81;	Sulfite exporter TauE/SafE	Enright A, Ouzounis C, Bateman A	anon	Enright A & Pfam-B_3578 (Release 7.5)	Family	This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane [1] during taurine metabolism as an exporter of sulfoacetate [2]. This family used to be known as DUF81.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.43	0.70	-4.92	912	12351	2012-10-03 02:02:08	2003-04-07 12:59:11	14	23	3983	0	3751	10142	8371	231.90	19	89.56	CHANGED	h.h.h..s..uhh..sG.hlsulhGh..GGul...lhlP..hLh......h.h..........h......................ssth.Ah..usshh....shhh..sshs.u...shs..a....h+....p.t.................l....s....h.p.h...........h..h...h....h.h.h......s.ulh.Gu...hl.G........uhlht..hls......sp..h.............h....phhhuh....hl.lhhuhhh...hh...........ptt...............................................ttt...................hhhthhhhhhh............u.hh.hGhh.uGhhGsG........uGshhsshhh..hhh...s.hshpp..ssuos.......th.hh....hhh........slsu.hhs.....a.............hh...........hGhls.....h...hhh.....h...lhhu.....ul...l..Guhl....Gsp.l....spcl....s.s...t..h.....l+hh...hshll..l.hhu....lth	...................................................................................................................................................hh.hhhuhh...uG..hlsul..hGh...GG..Gh.....lhhP.hLhh..h.....h........................s.sth..Ah......uss..hh...........thhh...sshs.u......sht...a........h+...........p...t............................................................l.......s.........h...p...h.....................h....hh.h...h..h....s.shl.G.u.......hl..G...............uhlht.......hls........sp......h..............................................................l..phlhsl.....hl....lh.h.ulhh.........lh.....p.p.h.........................................................................................................................t..t..............hhhphhh.hh.hh....................s..hh.hGhh..sGh...h...Gs.G....sGshhsshhh........hhh......sh.shpp.....ssuss....th..hhhh.s......................slsu.hhs........a..............hh........................................tGt.ls...........h....hhh.........h.........hhhu.sh..l....Guhl....Gsp..l.......s.t..p.h.......s..s......p.h.....l+hh.hh.h.lhh.hhuh.................................................................................................................	0	1230	2477	3207
+2347	PF01927	Mut7-C	DUF82;	Mut7-C RNAse domain	Anantharaman V, Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	RNAse domain of the PIN fold [1] with an inserted Zinc Ribbon at the C terminus [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.07	0.71	-4.23	57	605	2012-10-03 20:43:45	2003-04-07 12:59:11	11	11	493	0	310	595	66	132.00	26	50.48	CHANGED	.RFllDshL.GpLA+aLRhhGaDTh....ass.ch......................sDpplhplAtpEpRIlLTRD+tLhcRtthptt....hh..........................................l.pspcsppQLtElhp+hslph.phpP.hoRChpCNu......Lptls+pplhtp...............lP.tshphhpp...FhpCssCt+lYWcGoHacchpphl	.................................................................+FlsDshL.G.p.L.A.+hLRhh.GaDsh.......ass..sh..........................sDtplh.ph.AtpE.pRll..L..T...R..Dc....t....L....hc...+pthhtt.......hh.............................................................................l...pstp..p.pQhhclhp.ch.tl.t..tht..hsRC..CNs........L.....h.t.t.t.t.h....t........................................................l..h.h.t..t......a..C..CtplaW.GsHhtph.t..h...........................................................................	0	106	212	273
+2348	PF01930	Cas_Cas4	DUF83;	Domain of unknown function DUF83	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This domain has no known function.  The domain contains three conserved cysteines at its C terminus.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.20	0.71	-4.32	57	1113	2012-10-11 20:44:43	2003-04-07 12:59:11	12	15	868	0	454	1522	488	163.70	22	56.47	CHANGED	sGshlpYYhlCcRclWLhs+.pIsh-pssp.tVph..G+hlHE......psYp+..pp...+-lpl..s....shplDhlc....ttphhl...........tElKKSp+h.......pcAs.chQLhaYLahLc.cpGlpsp.GhLpYPcp++ppc....VpLs-cpccclccslpcIcpllppp.pPP.spcpp.hC.+pCuYh-hCas	..................................................................................................................h..shlp.ahhC...Rphhlhth...t..t.h.t...p....p........pht.......G....phlHc.................................................p...p.....tt..............cpl.l..p...................tuhh.D.hlc.........tt.tphhs..........................lEhK......c....u..ctt..............t...p...s....t....chQLsh..shh......L....c...h...h....G..h...p..l.p............G...........h.l..h..Y........s.....p......p....+....+....p.h.p............V.t.h....s....p....p...h......c....p.p....l....h......p..h..l....p.......p.....l....c...p.l.h........p....p......t.......h.s........P............s....p....t.p......p.....hC...ppCuhh.chCh...................................................................	0	183	320	397
+2349	PF01931	NTPase_I-T	DUF84;	Protein of unknown function DUF84	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this prokaryotic protein family is unknown.	20.40	20.40	20.60	21.10	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.59	0.71	-4.52	20	1061	2012-10-01 20:37:09	2003-04-07 12:59:11	13	5	1021	15	237	655	51	158.90	48	84.25	CHANGED	uSTNPAKIpAVppAFspsFstt.shclpGVsVsSuVsDQPhus-ETppGAhNRs+pAhphhspA-ahVGlEAGI-....s...thsFuWhVl.stp....ppG.u+SAuh.LP.hllcclh.cGcELG-VMDElsGpcNl+pKtGAIGlLTsspLoRoulYcQALIhALlPFhssph	..............................AosNPAKIpAlhpA...Fpcl...........Fu...pt......sscIsuVuVp.S.GVs.-QPhGsEET+tGApNRV...t....NA+..c.............h...h..P.........p..........A.........D.....aaVulEAGI...-..........s.................shT.F.uW.sV.l-sss........pRG..EuR.SAoLsLPsslLpcl+..p.....G..ctLGsVMsc..hsGh..cpItp..KpGAIGlFTsG+LTRsSVYaQA.VILALsPFhNs..lh.................................	1	59	118	177
+2350	PF01934	DUF86		Protein of unknown function DUF86	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of members of this family is unknown.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.21	0.71	-4.46	147	1619	2012-10-01 22:14:54	2003-04-07 12:59:11	12	7	989	2	590	1431	169	105.20	20	82.04	CHANGED	lhcslpplpphh........................................shs.hcpFh.p....sthhppAlh+plpllsEushclspc............................lhspp..thsa+phsuhRNhllHtYhs.lDhphlaphlpp.cl.......................ssLpphlppl	.........................................................................h..h...........................................t.t..hppah..p......sth...h...h.Ah.p.lphlhEushc.lspt.......................................lh.sp.ps.t.s.h.pphhshRsh....l.sHcYh.s...lc.h...chlap.hlpp.pl.......................s.lpphht..h.....................................	0	206	423	515
+2351	PF01935	DUF87		Domain of unknown function DUF87	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.62	0.70	-4.54	46	1158	2012-10-05 12:31:08	2003-04-07 12:59:11	12	19	801	0	504	4373	796	209.10	16	38.09	CHANGED	lp..lGpLh..ssss.............ls.ltlDl.schls+HhAIlupTGuGKSpssulllpcll.........phss..slllhD.HG.EYspht..........................tspsplhsst........................lpIshhplshp-ltplh.h....t.ssss.ppphlppshpphp..................pphtphshpchlpthhppht......................................................thpphptpshttlhpplpphhpphtth.........tshhptl.....cssplsIl..-lut.....lsptttph.lsuhlh+pl	.................................h..hGt........ttt...........h....sh..l.sl...pc.hl.......s.c....H.hu.l.h...GsTGoGKS.p.h.l.p...h..L..lc.phh..............................ttts......phll.lD.s..c.G....E..Yssht................................................................................................t..p..h..t...h..hp.t..................................................................................h.h.l....s....h...................h.......p................p......c.....h.............t....h...h..........................................................hh.....h.h....h............................................................................................................................................................................................................................................h..................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	154	317	410
+2352	PF01936	NYN	DUF88;	NYN domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion, unlike the FLAP/5' --> 3' exonuclease superfamily, which binds two metal ions.  Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.13	0.71	-3.91	149	2912	2012-10-03 20:43:45	2003-04-07 12:59:11	13	43	1840	1	1150	2564	397	149.80	21	49.81	CHANGED	+lAlalDspNhhhs.p..............h.chcplhpplpp...........tGp.....lhhtpsYss...............tttt..............ppht...shL......pphG..........h.sl.......phhshhp..............sK.sshDltlslDhhchs..sph...DshlLlSGD..uD...Fs.llpplc.ppG.hpl.lhu................t.tssps......Lhsuss.pal........lp	.................................................................................................................................................................lulhlDspNh.h..t.........................................h.s.h.ptlhpthtp..............................................hsp......lhhthhYss...................tttt.....................................pshh.....phL.............pphu........................................................h..tl.................ht.h.shht......................................tK.sssDh.tls..lD.hh..c.hhhp...pph................Dsh.lll..SuD.......uD.......Fs...ll.pplp..cp..G..hpV.hshu..h............t.hsspt......lhpsss.pah...t................................................................	0	388	740	969
+2353	PF01937	DUF89		Protein of unknown function DUF89	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has no known function.	25.00	25.00	26.10	26.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.29	0.70	-5.66	86	886	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	573	7	557	885	43	317.00	21	73.89	CHANGED	shtcphPsll.ppslsslch.........spss...............pptcpllpphtp..lhtchppspshssh..............................................htshlaRclhphhs..........phDsFpchKp.ps.ppuhphl.pltpp..hcphtsp......................hhpphlclulhGNhhDhulhs.........pp.......ttphppthcpsl...llsD.hsphhptL...................ppspplshlsDNuG.ElhhDhl.LhchLhc...huscVhhtsKshP.hlsDsThcDhp..................................................tttlpc....thscllhp...........u.ss...ssshshtch........ss-lhptlp..pu-LlIhKGphNYcpL.ps-tpht.p..................lhhLhssKs-slssh..sshscpl	..........................................................................................................pphsh.hh.pphhtt......................t....................t.hpthhtth.p...hh.p..h.t..p..t.....h........................................................t.shh..h.....cplhph.ht...........hDs.a.t.c.Kp.pp.......p.....t.uh.p..hh....pl.tpp.....hpphtpp.............................................hhphlchslhGNhh.Dhuhhs....................pp......................ttthtpthp.p.sh.................llsc..hsphhptL............................................tttppl....hlhDNuGhElhhDhl.l.......schLlp.......hu.......s.................cVhhts+shP.hlsDsT.hpD..ht......hh.t.....h.......................................................ttthpp.........t...t..s..p.lh.h.p.................................s..ss.....ssshshtph.....................................s.clh.pt.hp.....puc......LllhKGthNaRpLhssh........th..t......................................lhtLthhKsphlsth...t..............................................	0	199	329	463
+2354	PF01939	DUF91		Protein of unknown function DUF91	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this prokaryotic protein is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.24	0.70	-5.20	4	795	2012-10-11 20:44:43	2003-04-07 12:59:11	11	12	704	2	245	677	167	188.00	36	75.29	CHANGED	+ttlllllApCpV.YEGRA+ScLspG-RlllIKPDGoFhlHpD.+Kh-PVNWQPPsS..h.clptsph.lhSIRRKPcEcLcVpIpElatsosa.scDhc-LslsGsEu-MuchIhcpPpLIEEGF+PltREYtlspGhVDILGpDccGshVllELKRR+A-lpAVpQLKRYV-.h+c-hs.ttVRGlLVAPSlTpsAccLLc-EGLEF+cL-PP+ss....++shcstphchF	......................................................................h....hhlhupCpspY..G.Rh.pupLs..u.RllhhKsDsol.lHss.tuhcPlNW.sss.s..h.............t.......p......................t..................t......................................l.......h...h.t......t.......ss-.L.l.ht.h........cls......tssL.hs...G.lE..scLQcLLs-p....p.h.l.....u...p.G..hpll.c..R..E.......Y...........T.....s.....h.....G...s.....VDlLspD....t.s....G.s.h.Vs.lE..lK.R+...u....p.h......-uVc.QLsR...Y...l-..hL.sc........-...............h.......h...s.........Vp..GlhsA.pp.Ipsp.A.+h.L.h.p-+Glchlhl-..h...........................................................................	2	65	167	218
+2355	PF01940	DUF92		Integral membrane protein DUF92	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family have several predicted transmembrane helices.  The function of these prokaryotic proteins is unknown.	20.40	20.40	21.70	31.90	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.42	0.70	-5.20	79	583	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	495	0	375	586	324	246.10	29	79.32	CHANGED	ulhlsh.lLuhluh+tp..hLshuGhluAhllGshlhshsGhthahsllsFalhGShsT+hthppKpphul..s.ptcs.GpRshtpVhuNuhsuslhAlhhsh........................tstsh....hhhuahuuhAsstuDThASElG.thhspps.hLIT.Th.+.VssGTsGuVSl.GshAulhGuhlluhsuhhls....................hssth.....hhhl...sluGhlGohlDSllGAslQt..............................thshLsN-hVNhlsThhu...ullu	.......................s..hhsh..hls.h..h..u..h.p..p+..sLshuGhhsuhllGhh..hh.hhs...u....hthhhhLlsFFls.........uohhTKh..p..tph..K......pphsh..............s....pcs....GpRsh............hp......VhuNussusl.hulhhhh...........................................................hhssh..hhhu.hl.u....uhAsssuDTauS.ElG.hl..t.p.pP.hLIT...Th..+............hVs.sGTsGGVolhGhhAuh.hGuhhluhsshhhh.......................................hsh........hhhl......sluGhlGollDSlLGAslQt.....................................................................................................ths.hLsNpsVNhlsshhsuh....................................................................................	0	120	231	311
+2356	PF01941	AdoMet_Synthase	DUF93; 	S-adenosylmethionine synthetase (AdoMet synthetase)	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	This family consists of several archaebacterial S-adenosylmethionine synthetase C(AdoMet synthetase or MAT) (EC 2.5.1.6). S-Adenosylmethionine (AdoMet) occupies a central role in the metabolism of all cells. The biological roles of AdoMet include acting as the primary methyl group donor, as a precursor to the polyamines, and as a progenitor of a 5'-deoxyadenosyl radical. S-Adenosylmethionine synthetase catalyses the only known route of AdoMet biosynthesis. The synthetic process occurs in a unique reaction in which the complete triphosphate chain is displaced from ATP and a sulfonium ion formed. MATs from various organisms contain ~400-amino acid polypeptide chains [1]. 	19.40	19.40	19.50	37.60	19.30	18.50	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.30	0.70	-5.97	48	243	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	220	0	139	229	20	380.20	42	98.33	CHANGED	hRN...IsV-phpptsl-cpplElVERKGlGHPDoIsDuluEulSRuLs+tYl-+a.GslLHHNsDcs.lVuGputPcFGGGcVlcPIaIlluGRATpch......ts.p......lPlssIAlcAA+caL+cslthLDs-pc.lll-s+lGpGSsDLp-VFpcspt...lPhANDTSFGVGaAPLSpsEplVhpsE+hLNSp.hKpchPtlGEDlKVMGlRcsccIsLTlAsAhVDRalsshccYhphKppl+ctlt-hApph.....s..pccV.....cVtlNTAD...sh-csulYLTVTGTSAEtGDDGuVGRGNRsNGLITP.RPMShEAsuGKNPVNHVGKIYNlLuspIApclsccV-G.lcEVhVcLLSQIG+PIDpPhlAsspllsccG..hshsclcpclppIl-ctLsslsplocpllcGcl	.......................tNIhVp.hptpslpcpplElVERKGlGHPDoIsDulAEtlStsLuphYlc+a.GsILHHNhDcs.lVuGputPcFG.GGcll.cPIhIllsGRATpch......tspp....lPltplslcAA+caL+cslp.LDs-pc.l.ll-s+.........l..u.p........G.......S.........s..........DLh-lFpcttp..........lPhANDTShGVGaAPLopsEclVhpsE+h...LNop.t...h.Kp.....chPtlGEDlKVMGlRpscclsLTlAhAhls+alsshpcYhphK-plpptlpchupch...........s..tppl...........pltlNTuD....t.cpsslYLTVTGTSAEtGDDGpVGRGNRsNGLITPhRPMShEAsAGKNPVsHVGKIYNlLuppIAcclhcpl.cs.l.c-shVhlLSQIG+PIscPplsslpllscpu......h.t...phppclptIscc.LsslsplschllpGc.h..........................	0	34	81	112
+2357	PF01944	DUF95		Integral membrane protein DUF95	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family have several predicted transmembrane regions.  The function of this family is unknown.	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.33	0.71	-4.63	172	1288	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	1099	0	417	1025	82	170.70	20	68.88	CHANGED	lshllalhuhlhGh..hhsh......t.sphhpth..lst.h.thh.........................................h...hhtlhhNNh.tlshhshhhG...............lhh...Glsslhll.hhNGhhlGhshu..hhhppsh..........hh.hhthl....lPHGllElsulhluuus..Gltlu.................ht.....lltsth.................h........pphpsht...ptht...ptstlh..l.sshhllhlAuhlE.u..alosh	........................................h..hhhhhhuhlhGhhhs..........t.sph.pt.....hst..htphhtt.....................................t.t....h....hhtlhhNNh.h....lshhhhhhG.....................hhh.G.ls.sl..hhL..hhsGhhlGhhhu...hhhppst...................hhhhhhhl......lPHGllElsulhluuuh...uhp.lu.......................ht.......llpsth.........................h...............tct.p.slt.......pthh.......phhthh....l.hhhsllhlAuhlE.ualos.h.......................	0	141	283	372
+2358	PF01947	DUF98		Protein of unknown function (DUF98)	Kerrison ND	anon	DOMO:DM04314;	Family	This is a family of uncharacterised proteins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.94	0.71	-4.46	20	217	2012-10-01 19:33:20	2003-04-07 12:59:11	11	6	206	6	95	274	193	150.60	30	71.93	CHANGED	LLGDGSPTRHLpLL.TucpspV-lIsMts.s..sss..........spuPpcVppL.......ssPllRRQVWLps......uupsLAaApSWWNtpcs-caLps....+stPIWpsLspt+sELaRElcGltLspuc.hLEptFs.pcGPFWuRHYpFa+cG+sLTlIhEVFSP.tLEpaL	........................................lhuDGShT+hLpll..ss.c.pltVcllp.phhs..ss....................sth.t.hpth..............ss.llpRpVhL+s........................usphlsaAp..S.h..h.sh...s....cl....s....p.t....Lpp..........pshPIGchltpp.....+hE.....haR...El.t..p...lh.h...s.c.ss.....h...L.....t..pt....ap....p....c..t......h....h.u...RcYpl..h..ps.spPlh.lIpEhFs..............................................................	0	26	65	87
+2359	PF01949	DUF99		Protein of unknown function DUF99	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this archaebacterial protein family is unknown.	22.80	22.80	22.80	22.80	21.50	22.70	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.20	0.71	-5.19	29	165	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	161	2	106	166	10	177.70	29	89.74	CHANGED	KptlRllGlDDuhhtp.....cccshlsGlVh+ss.hl-GlhhsplslDGhDuT-sllshlps.phhtplpllhLsGlshuGFNllDlpclaccTtlPVIsVhc+tP-httlcpAL++hFscsp.c.Rhchlcph.Gphptl..............s.lahpshGls.ppAtcllpthohpu+lPEPLRlAHllApulhptp.+	.........th+llGlDDuhhtp................ptcshlsGslh+usthl.-Gl.shsplplDGhDAT-slhphlps...hth.plphlhLsGlshuGFNllDlppltccsshPVlsVhpctPchttlcpAL++.tFs.ssp....c..Rhphlcph.sphctl..............tslalpshGlshppAppllcthphpu.plPEPLRlA+llAsulh.....t...............	0	27	61	87
+2360	PF01207	Dus	UPF0034;	Dihydrouridine synthase (Dus)	Finn RD, Bateman A, Kerrison ND	anon	Prosite	Family	Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA.  Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae.  Most dihydrouridines are found in the D loop of t-RNAs.  The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap.  Dus 1 (Swiss:Q9HGN6) from Saccharomyces cerevisiae acts on pre-tRNA-Phe, while Dus 2 (Swiss:P53720) acts on pre-tRNA-Tyr and pre-tRNA-Leu.  Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD [1].  Some family members may be targeted to the mitochondria and even have a role in mitochondria [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.04	0.70	-5.59	17	9141	2012-10-03 05:58:16	2003-04-07 12:59:11	12	33	4628	7	2600	10106	4606	294.60	27	86.25	CHANGED	hlA.PMsGloDhhaRpLspchuss..........................LshoEMVsupshlpspphshthhsp.cps........hslQLsGs-PthhAcsAchst-.hGuptIDlNhGCPsc+VppstuGusLhpps-lltphlpshhcAVs...lPVTlKhRlGhD..-spppshchuctspssG.sphlslHGR.......T+tptaps..tAcaptItpl+psls...lPVluNG-Itsh...pcupptLptoGsDuVMlGRuAhspPhlht....tltpstht.pss.ht-h....hphhpp+hptlhphhu.tpulppht+HhtWhhpt...hssstth+pthspstshtch...httl....shhpsht	........................................................................................................lA.PMtshoDhsaR..........h.l.h....p....p....h.....us.s..................................................................l..h..h..o.E......M......l.........s....s.....p.........s.h....l.....h.....s.........s.....c....p......s......h......t....h.....h...sh.t..ppt...........................................t...lsl.Qlh..........G..s.-..P.pt.hu....c.s....A.c...h.......stp.....h.......G................s.....s............h................I.......D............l........N.h..G..........C.......Ps..p+..V........s.....p....p.....t.............tGu.....s.....Lh...p...c...P....c..l...l...t...pllp.uh..h.p.s.ls.........................lP..V.T.l........K....h....R......l......G..h-...................p.p..t.......p.....h........h...........-....hs...........p.t.........s................p.............p............s............G....s........s...........t..l.........s...........l.......H.u....R........................T.+.p.p..h..ap.......s...........p...s.......c...a......-......t.......I.......t....p............l................+....p...........p.......l...............s..................l....Pl..l.uNG...-...Ihsh...................pc...A...p..p...h......l.....p........t....s........G..........s.......D.........u........V.Ml..GR....u...Ah..s..p.Pa...lh..p..............h....h...p..p....t..........h...h.........s....t...s....tch.............................hp.hl....h....t....p....h....p..h..h......p........h..h..........s......................p........t......t...........t...h..t.....t.....h....p..+..p..h......h..h..h.pt..........h.s...s...t...t...h...+p.ht.t...tphtt...................thh..............................................................................................................	0	870	1575	2170
+2361	PF00692	dUTPase		dUTPase	Bateman A	anon	Pfam-B_127 (release 2.1)	Domain	dUTPase hydrolyses dUTP to dUMP and pyrophosphate.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.46	0.71	-4.68	29	7405	2012-10-03 01:18:03	2003-04-07 12:59:11	14	34	4788	263	1771	5446	3768	123.20	28	66.70	CHANGED	ppssh.sctpstsAGaDLhuspshsl.s..tssthlsTslthslPt.sphuhIhsRSul.utKGlllhs...GlIDpcapG.plplhlhNhspp.shplppGpRIAQLllh.hhp.....hp.spsh.cpopRGstGFGSos	.......................................t............suuhDl..h...s.......s................s.......h.......h......ltP.....s........phs....LlsTs.l..t..l..p..........l...........P.........c...sh....h........u.........h...........l....h.sR.Sul...u.p.p...t...h..l...l...h...s...Gh.I.DssY......c.....G...p...l..t..lt..l......h.N......h......u..........p...t...sh.......p...........lp......sG-RIAQh.lhh.h.p.............sth.p...h....p...ph.....s......t.....p...+GptGhs..........................................	0	563	1093	1455
+2362	PF02670	DXP_reductoisom		1-deoxy-D-xylulose 5-phosphate reductoisomerase	Bashton M, Bateman A	anon	COG0743	Family	This is a family of 1-deoxy-D-xylulose 5-phosphate reductoisomerases.  This enzyme catalyses the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH [1]. This reaction is part of the terpenoid biosynthesis pathway.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.66	0.71	-3.60	87	3428	2012-10-10 17:06:42	2003-04-07 12:59:11	11	6	3275	79	838	2723	1839	125.40	42	32.41	CHANGED	lslLGSTGSIGspTL-V..lp...pp....P-.pFplsuLsA.spNlchlhpQs..pp..F..pPph..l.sls-ppt....hppLpptl........t.......tsplhhGpcult...clAsh....scsDhVlsAIVGsAGLhPTlAAlcuG.KpluLANKEoLVsuG	..................................................lsILGSTGSIGspTL-Vlp...pp...........P-....pFcVsALsA.GpNls.hlscQs..tcF..pPch..s..sls..-..p.ss......spp.L.c..ptL.............s..........................tsclh.sGppuls....-lA.sh..........s-sDhVhsAIVGu.AGLhPTLAAlc.AG.KplsLANKEo.LVsuG.........................................	0	295	570	722
+2363	PF00350	Dynamin_N	dynamin; 	Dynamin family	Finn RD	anon	Prosite	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.96	0.71	-4.43	79	6429	2012-10-05 12:31:08	2003-04-07 12:59:11	18	111	1940	32	2723	11019	2690	176.80	21	26.13	CHANGED	lsVlGs.SuGKSSlLpuLlGpch..LP..puss...sTcpslh.lph.........................................scp.p.............sphp..ht-h.....tpphpshsplppthpppppphs.....th..................................................................slhhphhs.ts.sloLlDhPGlsp..ssstcp.................shsppal.ppsslILhl.s.sust...shups..-thplspplDspsp+.........o.lsVlsKs	.......................................................................................................................................................................lsllGs..SuGKSo...llp.u...l....l....G.........p.......c.....h.........LP....puss.............s..T.p...p.s.h.....h..lph..................................................................................................................................................spptp...........................................p..htp........................tpthps..h....p....p.......l...t....p.t..h..p..t..p..h.p...t...h..t....................................................................................................................................................................................................h....h....h..h.s....h..h............s...l..s..l..lD..h.P......G.ls...p...ssstpp...................................................phhtp...h...l...p..p......s.......s...h..l...l...hl..h..........s.ss.p.......s.hs.....ps.....-.......h.............h.h...h....p......h.c....t.t..h..............h.hhlhst....................................................................................................................................................................................................	0	828	1542	2205
+2364	PF04912	Dynamitin		Dynamitin 	Finn RD	anon	Pfam-B_5757 (release 7.6)	Family	Dynamitin is a subunit of the microtubule-dependent motor complex and in implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS) [1].	25.20	25.20	25.20	25.30	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.28	0.70	-5.66	8	360	2009-11-18 13:30:50	2003-04-07 12:59:11	9	7	237	0	243	360	0	273.70	22	85.27	CHANGED	hIuhsQ.DlYETsDsPEs-ssph..pp-EssscsIEplplssscAapKFps+plsssslDFSDpIuK+p..+pGYphc.puEaEllGp..uppETPhQKhQRLQpEhtELh-Elpshpsssppsc.EEclSssAL.upslssLccpLcsL....+LppllGp.csl.sssp..t.s.sp+LloplEpa...........p.........pp.s.hutsssp............ptschspsu+lAsLE+RLtcLEsslGs.cs-h.s.Lssshp..sssll-u.....lpplpuKsuLLssspLDtlEpRLsslhtKhppIs.E++sus.pDssp-pKIs-LYElspKW-slspp....LPpllpRLpoLcuLHcpAspFuptlupL-ssQpslpspLssspsLLpcVpcs.....htpNLpslp-slsplEuRltsLp	..............................................................s...........................................................................................................................................................................................................................................................................................................................................................-.........s............p+htRl....Ehtph.t...ph.......t..t..........................................tt................t.............h....p.htt...hpp.L.t.......................t.p...........s.....................................tt.....tht....................................................................................................................................................p........t..........t......t....chsph-pRlt.lEthlt...t...................t...............tslh.s.................lp.lptp..lsh.L...p.........t........lpthptcht....l..tchp.......t......l.........t....p....tp..............t...............t......................................t..............t...............t................p..............p......p.............p..........K..............l.......p.t.lathh.phpshts................lP.llpRlhslptlHttAh.phs.......p.lptl-pppt.htpplpp.pphlptlppt............htpshthhtt.httlct+htt..t............................................................................................................	0	80	126	197
+2365	PF01221	Dynein_light		Dynein light chain type 1 	Finn RD, Bateman A	anon	Prosite	Domain	\N	24.90	24.90	25.00	25.10	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.12	0.72	-3.99	75	1105	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	322	46	723	974	9	86.60	39	73.19	CHANGED	h.....s..ptps.hlKssDMs--..Mpp-AlchutpAl..-....+as...h-..+-.lAtaIK+EFDc+YGsoWHCIVG+sFGSaVTHEsppFIYFhls.ph..ulLLFKou	.............................................................pshl+ssDMs--.....MQp-Al-.h....A......p..pAh.....-........+as..........h-.........+-..lA....taIK..+.-F.......D++Y.......s.......s.....o.......WH.C.I.V..G..+...s..FG...S.aVTH.....EsppF...l..Y.Fh.lu..pl.ulLLFKo.............................	0	331	455	616
+2366	PF00519	PPV_E1_C	E1; 	Papillomavirus helicase	Finn RD	anon	Pfam-B_48 (release 1.0)	Family	This protein is a DNA helicase that is required for initiation of viral DNA replication.  This protein forms a complex with the E2 protein Pfam:PF00508.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.55	0.70	-5.87	66	1112	2012-10-05 12:31:08	2003-04-07 12:59:11	12	7	265	44	9	1576	23	256.40	49	68.38	CHANGED	KFK-saGlSFs-LTR.FKSDKTsCpDWVlssa.GlpcslhEusKpLLppaCtYhalpp..stthGhhsLhLlpFKsuKsR-TVtKLlsslLsVs-pphLhEPPKlRSssuALaWYKpuhussshs..aGphP-WIs+QTllsHp..hpsspF-LSpMVQWAYDN-hs-ES-IAYpYApLA-pDuNAtAFLpSNsQAKaVKDCusMsRaYKRAEM+pMSMSpWIpcRspcl.-..ssGcW+sIVpFLRYQslpFIsFLsAhKpFL+G..hPKKNClllaGPPsTGKShFsMSLl+FLpGpVISasNS+SHFWLQPLsDAKluLLDDATpsCWsYhDsYLRNuLDGNslSlDtKH+uslQlKsPPLLITSNlsltp-c+apYL+SRlpsFpFss.FPhcssGsPlapLsDpsWKSFFpRhWspL-Ls-.pED-s.-..s....GssppsF+C	..............................................................................................................KFKEhYGlSFhELlRsFKSsKosCsDWslusF.Gl.ssolAEuhKsLlp.ashYhHlQsL.ss..shG.hllLhLlRaKCuKNR.TltKhlupLLslspppM.lI-PPKLRSsssALYWY+ouh..S..Nh..SpV..hG-TPEWIpRQTllpHu...h.p-.s.F-LSpMVQWAaDp...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	4	8	9
+2367	PF00122	E1-E2_ATPase		E1-E2 ATPase	Sonnhammer ELL, Bateman A	anon	Prosite	Family	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.33	0.70	-5.32	126	30268	2009-09-12 10:17:11	2003-04-07 12:59:11	15	261	5547	105	10217	25831	1942	229.00	24	26.96	CHANGED	hllhhlhlsshlphhpch+upcslppL...tphtsp.p.spVhcs...........................s...........phpp...............l.sspclssGDllhl.csG-plPuDuhll.........................................p...s..........shplDcShLTGEo.......hPlpKp..........................................psshl.....auGohlh...sG..ph......pshVstsGpsopluclsphl...ppspp.tc....................................sslpphls+lsphhshls.lslul.......................lsh...hhthh........................................................................t.shhpslhhu.lulllsusPpuLslssslslshuhtphu+pslll+.phsulEs	..........................................................................................................................lhhhlhls.t.h.l....p.h.h.t.....c...t..+.u.p...ps.l.p..t.L.........h..p...h.t..sp.....p.............s.p..l....l....c..s..............................................................................................G.......................p.h.t.p...................................l...sspclh...s.......G.Dll......hl......c............s..............G...........-.............p........l...P..sDuhll..............................................................................................................p.......u.................pstl..DE...S..h..LT......G..ES..............hPVpKp...................................................................................................................................................tssh..l......h.u..G..o.h.sh............sG..........ph............................hh..h..V..st........s.G.....t.cT..h..l.....u...p.........l........h.ph.l......p..pspp...pc................................................................................................................ss.l..pp.hh.s....p...l.u.t.h..h..s.h..h..s....l....hlu.h.........................................l.sh...........hh..hhh..................................................................................................ttsh..h..t..sl...h.hu...l...sl....l....l...s...ss...P...puLs..ls....ssh.slhh............u....s...t.....ph.u.c.p.s.hl....l+phtulE...........................................................................................................................................................................................	0	3318	6138	8457
+2368	PF00676	E1_dh	E1_dehydrog; 	Dehydrogenase E1 component	Bateman A	anon	Pfam-B_117 (release 2.1)	Family	This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.82	0.70	-5.70	16	9023	2012-10-02 16:07:47	2003-04-07 12:59:11	15	32	3995	112	2879	10789	7579	299.30	26	49.43	CHANGED	tchhslpRht-ttthhapcpthhGFsthpsGQEAsslGhttAlspp.Dhlhss..YRspuhh.hh+Ghs..lpplhsphhG+t....pspGGuh+..hh..s+p...ahsusuhlusQ...slss..GlAhAtK..........hcpcppVshshaGDGA.osQGphaEuhNhAslachPl...IFlscNNpauhuT.ssc+uuussshhphutGhtIPGlpVDG.DhlAVhpAsKhAt-hsppGpGPhLlEhhTYRhsGHShS.DssooYRspcElpch+tpcDPIpth+ctllspGlso--Ehcshccclcpcl--AhcpAcsss.sssp	.....................................................................................................................h.....htt.h..p...h.t.h.h.h.t.......t.t..t..........p.h..u..h............t..st...su........p............p.....Ah..p..huh..t...t....u..h...p.....t......s.....D..h..l..h..st..........a..Rs+.s..ph..l.s...p.....s.hs................hppl.....h..s.p.h.h.Gct..........................................psp.u..s..s...h..p.............h......h............................s.......p.........t...................p........h.h..s...s..s.........s........lusp................P....lsh.............Gh..AhAt..p................................................h..p....s....p.......p.....s....l....s.....l...s.h.a.GDuA.su........QGsh.aE....sh.N....h...A.....s.l.....h............p.....h.....s.s.....................l.a.l.l..............N.N...p..h...uh..o.........T.....s......s...........p.........c....s.p.......u......s.p..........h.......h.s........c........h..A........t.u.......h........s....hP.s..h...c.......V......s..G..s...Ds.......A.Vh.....t....s.s....c.hAh-..h....t....p....p...........h..........c...........t....ss.lI-h.h.s.Y..Rh.tG..H..s...pu...D.....c..P...s....t...h............p.....sp...........h.p.p.h...p.p.c.......s....Pl.th.apch..L.h.....p.........p...G.........l.........h..o.p...-...c..h...p...ph...t...p...p...h...c...p...t...lp.ps.hp.spt.......t...............................................................................	0	974	1810	2435
+2369	PF00524	PPV_E1_N	E1_N; 	E1 Protein, N terminal domain	Finn RD	anon	Pfam-B_98 (release 1.0)	Family	\N	22.50	22.50	23.20	25.40	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-11.07	0.71	-3.92	76	514	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	242	0	0	513	1	123.50	39	22.24	CHANGED	MA.....s.scGTc........ttssss.GWhhl..EA..ssc......spD-..Esh..h-p.....soDlsDhI.Dsssh.....pQssuhtLap.pQpspcsppplpsLKRKYht.....SPtss.........ppLSPRLpuls..lssp.pppuKRRLF.p.....DSGhup...ots-	...........Ms-.spGTss......tttGssGWFhV..EA..spc...s..o-D...-.tEp...t-s.....spDhs-FI.Dsss......pptsuptLap.tQpsppct..pslp.sLKRKahs.....SP.ss........sppplSPRLpuIs..ls...pp....pppuKRRL.Fp.p....DSGYGsops.......................................	0	0	0	0
+2370	PF00511	PPV_E2_C	E2_C; 	E2 (early) protein, C terminal	Finn RD	anon	Pfam-B_87 (release 1.0)	Domain	\N	25.00	25.00	25.30	25.30	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.69	0.72	-4.02	99	565	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	249	38	0	497	0	76.60	44	22.58	CHANGED	PllhL+G-sNsLKChRYRlpp+apsL.FpphSoTWpWss....ssssp.psuhlhlsasoppQRppFLssV+lPpulphthGhhs	...Pllpl+G-uNsLKChRYRl.p.+appL.apthSSTW+Wsu.........sss.pp.puhlTlTasScpQRppFLssVKI.P.solphshGhMo.............	0	0	0	0
+2371	PF00508	PPV_E2_N	E2_N; 	E2 (early) protein, N terminal	Finn RD	anon	Pfam-B_76 (release 1.0)	Family	\N	19.10	19.10	20.60	43.80	18.20	18.10	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.35	0.71	-5.14	82	467	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	250	13	0	494	0	197.90	44	51.73	CHANGED	MEsLspRLsusQEp...lLslYEpsSpsLp-QIpaWphlRpEpsLhatARcpGlp+lGaQsVPsLsVScsKA+pAIchpLtLpoLppStYupEsWTLp-TShEha.hssPppCFKKtGpsVEVhaD.s-ppNsMpYThWshIYhpssss..WpKspGpVDapGlYY.ptpstK.pYYVpFpc-Ap+YGpoG......pWEV+..hsspslhsP.sosoS	....MEsLspRLsAsQ-c...lLslYEpDSscLpspIpaWphlRhEsslhYtARctGlp+lsa.QsVPsLsVScsKAppAIEhQltLcoLppSpYusEtWTLp-TShEha.hosPppCFKKpGhoV-VhaD.s-psNsMpYTsWstIYhpsps............s...............Wp+VpGpVDapGlYY..hppGh.+..sYYlpFp.c.-Ap+Yupos......hWEV+..hssplIhsPsos..............	1	0	0	0
+2372	PF02319	E2F_TDP		E2F/DP family winged-helix DNA-binding domain	Mian N, Bateman A	anon	Pfam-B_8420 (release 5.2)	Domain	This family contains the transcription factor E2F and  its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a  homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows  that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.	21.20	21.20	21.30	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.61	0.72	-4.41	33	1416	2012-10-04 14:01:12	2003-04-07 12:59:11	15	13	169	2	833	1251	16	71.90	39	20.10	CHANGED	RpcpSLslLop+Fltlhpp....spc.shlsLscsAcpL....................ss..p+RRlYDIsNVLculslIpK.......hpKsplcWhG	................................................RhppSLthhopKF.ltlhpp..................sps....usl...sLs..p.....sAcpL...............................................ss..p+RRlYDIsNVLpulslIpK...........tpKsplpWhG............................	0	297	417	591
+2373	PF02817	E3_binding	e3_binding; 	e3 binding domain	Griffiths-Jones SR	anon	Homstrad	Family	This family represents a small domain of the E2 subunit of 2-oxo-acid dehydrogenases responsible for the binding of the E3 subunit.	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.38	0.72	-4.32	58	9252	2009-01-15 18:05:59	2003-04-07 12:59:11	12	41	3883	49	2483	6857	3964	38.30	38	8.78	CHANGED	scshAoPssR+LApEpulDLs...plp.GoGssGRIh+pDlps	...............hsoPssR+lApE.p.G...l...-....ls....pVp..G.oG.h.p.G.RIh+cDVp..............	0	779	1517	2071
+2375	PF00518	E6		Early Protein (E6)	Finn RD	anon	Pfam-B_57 (release 1.0)	Family	\N	20.70	20.70	20.70	21.80	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.34	0.72	-10.86	0.72	-3.72	26	915	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	239	6	1	645	5	108.30	48	74.15	CHANGED	ClaCpchLspsElhsFsh+-LplVaR-s.hsausCstCLphhuplcph+aaphSlausslEphstpslhclhIRChhCt+.Ls..EK.cpl.ppcpF+clp.spW+GpChpC	........................................CVaCKppLpp..pEVacFAapDLplV..YR.Du...PaAlCctCLchhSK..lpch.RaYp..hSlYGsT.LEphhpKsLs-lhIRChtCQ+PLsPpEKp+HlspppRFHpIp.G.....cWpGpChpC........	0	0	0	1
+2376	PF00527	E7		E7 protein, Early protein	Finn RD	anon	Pfam-B_95 (release 1.0)	Family	\N	21.50	21.50	22.10	22.10	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.56	0.72	-3.83	75	626	2009-09-14 14:24:34	2003-04-07 12:59:11	13	1	232	5	0	438	1	91.80	40	93.18	CHANGED	G.........p.psTLpDIVL..ch.pP.........pslD.LhCpEpLs....sop..-.........-Esc.t......................psYpllssC.sp..Cppsl+LsVpuopss.lRsLppLLh.ssLslVCPtCu	...................................................Gp.psTLp-hlL..-L..pP..........pssD.LaCaE.QLs....cSs.-E........-E...chst..t..............p.tpssYtIlThC..sp..CcsslRLsVpSTps-.lRsLQpLLh.GolslVCPtCu..........	1	0	0	0
+2377	PF00563	EAL	DUF2; 	EAL domain	SMART	anon	Alignment kindly provided by SMART	Domain	This domain is found in diverse bacterial signaling proteins.  It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function [1]. The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site [1].	21.60	21.60	21.80	21.80	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.59	0.70	-4.88	137	26968	2009-09-15 16:29:44	2003-04-07 12:59:11	15	1049	2504	33	6836	21773	1845	227.50	27	36.53	CHANGED	tpplppu...h..tpt..ph.thhaQ....P.lh...s.hpssp....lh...uhEslhRhpptptt.hl..sstp......ahshhcp........shhtpls.phllcpshp.phtph.........th.l..slNl....ss.tpltssp...hhptlt...thh.........th.ssp.lslElsEs..................pphp..phlp....p.L+p...hGhplulDcF..Gsshs.shph.ltplshc..hl.KlDpphl..tth.....stpspthlps........lhphucph........shpllAcGVEspp..phphltphGsc.....hhQ..Ghhh...upP	.............................................................................................................................................t...ltpA.....l....ppp.....ph.hlhaQ..........P..hl...............s..hpssp..................lh....GhEu...LlR...a..pp..s..p....t...s....hl.....sPsp.....................Fl..s.hAEp.................................t....Ghh.htls..phllc.pshp....p...ht.p.h.....................................shpl.....................ulNl.....................Ss...tp....l....tpss............hhp.plt.....phl.........pph.tlss..p.p....l...t..lElTEs.........h..............hps.tp..h.h.p.hlp............p..L+p....hGhpl.u..l......D..DF...........GoGaS....oL.......sh...L....pp...h...s..h..D.......hl.K..I..D+uFl...............pslt......pst.......p....s.....pt.......l.l.p.u.......................ll..p.l..u.c.pL........s.h....p.l.l.AEGVEopp...php.h..L.p.p.h..G..s.s........hhQGahau+P......................................	1	1860	4128	5580
+2378	PF04157	EAP30		EAP30/Vps36 family	Wood V, Finn RD, Bateman A	anon	Pfam-B_8830 (release 7.3);	Family	This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking.  EAP30 is a subunit of the ELL complex.  The ELL is an 80-kDa RNA polymerase II transcription factor.  ELL interacts with three other proteins to form the complex known as ELL complex.  The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity [1].	25.00	25.00	25.10	25.00	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.28	0.70	-5.19	67	648	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	296	8	450	643	7	216.70	26	60.19	CHANGED	sGluulpppptpppphs-hshphshp..clspLhpphpphhphhcphupptpschppssp...................phpphhsslGlss.....hsstc................h..uhspFa.ELuhplsEhsh........phhcpsG.......................G.....llsLp-lashhN+.....sR.tst......................................hlospDlhcAschh.cpLshs.hplhphs..............tuhhhlpsss.s-h.tspsplLphh............................................................................phtsslohtplspphs.......WohshupptLp..p.hhppGhlh..hD	...................................................sGluulpppt..pppp.sctsh..s.uhp..clspLh...........pphpphhshhcphApc..h..p..p.ch..p.p.s.sp.hcs.......................................pFpphstslGlss.........................sopc........................h...uhspaahELuhpl..sEhhh..............sshpc.sG......................................................G.........lls.Lp-lhshhs.+......uR...uhp......................................hlS......s..-DlhcAschL..csL.......shs..hplhphs.....................G.hhllp....shs............s-.........pstsplLphs...................................................................................................pht...uhlosppltppls...................WshthApphLp...t.h.ppGhlhhD............................................	0	156	251	373
+2379	PF01309	EAV_GS	EAV_env_prot; 	Equine arteritis virus small envelope glycoprotein 	Finn RD, Bateman A	anon	Pfam-B_656 (release 3.0)	Family	Equine arteritis virus small envelope glycoprotein (Gs) is a  class I transmembrane protein which adopts a number of different conformations. 	25.00	25.00	440.70	440.50	18.00	17.50	hmmbuild  --amino -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.41	0.71	-4.80	7	84	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	2	0	0	84	0	196.00	95	86.34	CHANGED	WWRAVHEVRVTDLFKDLQCDNLRAKDAFPSLGYALSIGQSRLSYMLQDWLLAAHRKEVMPSNVMPMPGLTPDCFDHLESSSYAPFINAYRQAILSQYPQELLLEAINCKLLAVVAPALYHNYHLANLTGPATWVVPTVGQLHFYASSSIFASSlEVLAAIILLFACIPLVTRVYISFTRLMSPSRRTSSGTLPpRK	WWRAVHEVRVTDLFKDLQCDNLRAKDAFPSLGYALSIGQSRLSYMLQDWLLAAHRKEVMPSNVMPMPGLTPDCFDHLESSSYAPFINAYRQAILSQYPQELLLEAINCKLLAVVAPALaHNYHLANLTGPAsWVVPTVGQLHFYASSSIFuSSVEVLAAIILLFACIPLVTRVYISFTRLMSPSRRTSSGhLPQRK	0	0	0	0
+2380	PF02905	EBV-NA1	EBNA1; 	Epstein Barr virus nuclear antigen-1, DNA-binding domain	Griffiths-Jones SR	anon	Structural domain	Domain	This domain has a ferredoxin-like fold.	25.00	25.00	53.10	53.10	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.54	0.71	-4.72	5	148	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	9	4	0	87	0	90.90	90	66.67	CHANGED	KGGWFG++RGQGGps.sKFEshA-uL+ALLuRCcuPRTosEGcWssGVFVYsGSKTSCYNLRRuLALCIPECRLTPLuRLPYGaAPGPGPQPGPLRESossYFLVFLQTplFAEClKDAI+DYIpT+PsPTssl+VTVCoFD.DuVML	.....KGGWFGKHRGpGGSN.QKFENIAEGLRhLLARCHVERTT--GsWVAGVFVYGGSKTSLYNLRRGIALAIPQCRLTPLSRLPFGMA................................................................	0	0	0	0
+2381	PF00378	ECH		Enoyl-CoA hydratase/isomerase family	Finn RD	anon	Prosite	Family	This family contains a diverse set of enzymes including: Enoyl-CoA hydratase (Swiss:Q13011). Napthoate synthase (Swiss:P27290). Carnitate racemase (Swiss:P31551). 3-hydoxybutyryl-CoA dehydratase (Swiss:P52046). Dodecanoyl-CoA delta-isomerase (Swiss:P42126).	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-5.25	13	26211	2012-10-02 13:07:06	2003-04-07 12:59:11	15	113	4081	502	8836	22457	13530	233.90	23	67.75	CHANGED	phphpsulAhlplcpPt.slNulssphlsElspulpphcsDssl+.ulllouscpsFsuGuDlp-hsst.....tp.sshptsstclapclpssshPllAAlNGhAhGGGhplALssDhtlAucsAp..hGhsEsplGlhPuuGGo.hLsRhlGhstAh-hlhsGcphsApEAh+hGlVspVVs............p-p.lhcpAlphspclssp............s.hulshhKphhpt.....hcpslspstptstptasushssccspcuhpu...................ahEc	............................................................................................................h....tssls.hls.l..sR...Pp...t.....hN....A.l...s......t...h.h.p...p..............l.........t...p...s...l.........p....p....h............p............p...........-.............s......s.......l.........c....s....l....l........l............s.......u............s.............s............c............s............F......s.............A.............G............u....D....l.......p.......t.......h.tph.........................t.....t.....h.........t..........t.........h.........h............p............t...............h................t............p................h.........h............p.........t...........l...........p.............p.............h.............s............+....P....l......l.Au...l...s..............Gh.AhG.G.G.h.p.Ls...h.s...s...D....h.t.l.................A............u.c..s..Ap..............h...u..h.s..c..s.......p..l..G....l.....h......P.......s....s.G.....u.s.........................h...L....s....+...h..l.............G......h..........t......t........A...h..........c.h............h...........h............s.....G......c...t..h............s..A.pc..A.h.p..h..........G...L.l....s..p.....l...ls......................................................................tsp....l........p....t....s.........h....p..h...u......p......p..l....t..tt.......................................................................s.s..h..u..h..t...h...h..K..t......h..h..pt..................t...........t...t............t.......t.......t.....................h.......t.....p...t....................................................................................................................................................................................	0	2394	5222	7277
+2382	PF04736	Eclosion		Eclosion hormone	Kerrison ND	anon	DOMO:DM04950;	Family	Eclosion hormone is an insect neuropeptide that triggers the performance of ecdysis behaviour, which causes shedding of the old cuticle at the end of a molt [1], [2].	25.00	25.00	48.60	47.90	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.34	0.72	-4.53	6	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	31	0	29	44	0	60.10	58	68.49	CHANGED	phDlhGGYDhluVCIsNCAQCK+MaGsFFEGpLCAEAClpFKGKhIPDCEDIuSIAPFLNKL	...........s.hsGhDhltVClpNCAQCK+MaGsaFpGphCA-uClKFKGKhIPDCEDluSIuPFLNtL...	0	8	11	26
+2383	PF02963	EcoRI		Restriction endonuclease EcoRI	Griffiths-Jones SR	anon	Structural domain	Domain	\N	19.90	19.90	20.30	20.70	18.60	19.40	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.51	0.70	-5.59	3	52	2012-10-11 20:44:43	2003-04-07 12:59:11	11	1	50	10	6	62	7	187.20	49	86.48	CHANGED	SpGVlGIFG-tAKtHDLoVGEVS+tVlsKLoEDYPQLoFRYRsSIcKKEINEAL+KlDPcLGQTLFVENASI+PDGGIlEVKDDaGNWRVVLVuEAKHQGKDIENIRsGlLVGKsKDQDLMAAGNAIERSHKNISEIANFMLuESHFPYVLFLEGSNFLTEoIcVTRPDGRVVsLEYNSGMLNRLDRLTAANYGMPINoNLCcNhFV+HKDKoIMLQAASIYTQGDGusWsuucMFEIML-ISKTSLRILGcDLFcQ	..........................................................................................................h+tplphp.h..N.hLptlcschs.pohFh.sspIKPDGGll..cl..KD..Dpt.h+l.lLloEAKhQGps..pIpt..h.GKtpp....tsGNAIERuaKNlsElANhMLpEt+FPYllFL-GoNFlTpsh.l.RPDGRhl.l.YssGhLNRlD+LTuANY.GMPINpNLC.N+Flphpst.IMLQAhSIYTpGpGttWs.p.Mh.hh.....................................	0	1	4	5
+2384	PF03974	Ecotin		Ecotin	Finn RD	anon	Pfam-B_54504 (release 7.2)	Family	Ecotin is a broad range serine protease inhibitor, which forms homodimers. The C-terminal region contains the dimerisation motif [2]. Interestingly, the binding sites show a fluidity of protein contacts binding sites show a fluidity of protein contacts derived from ecotin's  innate flexibility in fitting itself to proteases while [4,5].	22.20	22.20	24.00	24.20	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.76	0.71	-4.42	47	725	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	700	31	89	328	19	124.20	65	76.27	CHANGED	tcphts.aPtspsGhpRpVIp....LPt.ss...Es...sa+VELlsG+shpl...D.CNpptLu.Gplpp...........colcGW.GYsYYplsths...ss.......oThMACs...spt+pppFVsl..ust..hlpYNS+LPlV.VYlPcssElRYRlWp......up	..............L.EKIAPYPQAEKGMKRQVIp....LsPQcD...ES..........sLKVELLIGQTLcV...D.CN.hH...RLG.GcLEo...........K.T.LEGW.GYDYYVFDcVouPV.........STMMACP...DGKKEpKFVTAaLG-su.MLRYNSKLPIV.VYTPcNVDVKYRlWKA...............	0	13	29	57
+2385	PF00736	EF1_GNE	EF1BD; 	EF-1 guanine nucleotide exchange domain	Bateman A	anon	Pfam-B_488 (release 2.1)	Domain	This family is the guanine nucleotide exchange domain of EF-1 beta and EF-1 delta chains.	20.80	20.80	21.40	21.00	20.50	18.10	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-10.04	0.72	-4.29	87	874	2009-01-15 18:05:59	2003-04-07 12:59:11	14	17	487	11	461	872	67	86.40	48	37.56	CHANGED	hop....lllcVhP.s..sEsDhccLpcpl.cslptcul..s.s.ch.PluFGl+tLplhslltD.ccsusDpl.pEtl...sh.-t..........................VpSs-lsuhs+l	...................................KSs..llLDVK..PWD..DETDhpcLEcsV.Rul.p.h-..GLl......W.....G.uuKLVPVGaG.IKKLQItsVlED..DKV.usDtL.pEpI......pth--a..................................................VQSsDlsAhsKl.............................................................................................	1	149	255	374
+2386	PF00647	EF1G	EF1G_domain;	Elongation factor 1 gamma, conserved domain	Bateman A	anon	Prosite	Domain	\N	20.70	20.70	25.40	25.40	20.60	19.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.25	0.72	-4.34	40	588	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	372	1	292	576	1	100.60	47	27.49	CHANGED	Ksc.cPh-..sLPp...uoFs.lD-aKRpYSNpDT..hss..AlPaFW-p.aD.sEsYSlWhscYK..Ys-EL..ph.sFMosNLluGah.QRL..-.phRKauFushslaGcs.ssssIsGlalhR.....Gp-	.......................KsKcPh-tLP+.........uoFs.LD-aKRhYSNc-o...hsV..AlsaF.W...........-p....a..D...Es.a.SlWhs-Y+..Ys-EL..oh.sFMSsNL......lsGhF.QRL..-.thRKhuFushhlaGps......ss..ssIsGlalhRGp-................	0	96	162	239
+2387	PF00889	EF_TS		Elongation factor TS	Bateman A	anon	Pfam-B_1408 (release 3.0)	Family	\N	21.00	21.00	22.50	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.43	0.70	-5.02	168	5433	2009-09-12 05:55:42	2003-04-07 12:59:11	14	21	4607	24	1441	3651	3185	191.80	35	74.06	CHANGED	AuEGllsshl..psst........usllElNsETDFVA+s-pFpthspplsphsh.............t.....pt.sshc...........tlht..h.t.....tslpphhtthhuplGEphpl+R..h.thhps.....s.h.ssYlHst.............u+lGVllthpss.t.........plu+clAMHlAAhsP...phlstc-lss-hl-..+E+............................cl.............hptpstp.......................................p....GKP....................................................p...plh....-K.....llpG+lpKah.......pEhsLLcQsFV..p.DschTVpphlcptss.......pltpFsRaclGE	.................................................................AAEGllt..shhpssh..........usllElNsETDFVA+st.....tF.thspplsphhh........................................t...tp...ssh-......................th.h.t...............phppthhthh..u.p.IGEplplRR.........h.thhpt..............th......hssY..Ht.........................s+.l.GVls...h..pusst............................phu+plAMHlAAh..pP......phls...c.-..lst-h.l...c.+Ep.............................................pl..........................................hhppshp........................................................p..........GKP..........................................................cpIh-K.......hlpG+hpK.ah.......pEh.sLhsQ..s..al.......h.-...s..p...h.TVtphlcptss........plhtFhRaclGE.................................................................................................................................	0	539	975	1245
+2388	PF01132	EFP		Elongation factor P (EF-P) OB domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.90	20.90	20.90	21.10	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.58	0.72	-4.29	271	5656	2012-10-03 20:18:02	2003-04-07 12:59:11	15	10	4552	12	1140	2928	2197	55.20	32	29.59	CHANGED	c+chpYLYpDG-.t.ahFMDs-.oYEQhpls...tctlu.-shpaLpE..shplplhh..as.spsl	........+shpYLYp.D..G-..t.ahFMDsE.oYEQhpls...tctlt...-.phpaLhE..sh.p..splhh..as.Gpsl....................	1	382	741	957
+2390	PF04863	EGF_alliinase		Alliinase EGF-like domain	Mifsud W	anon	Pfam-B_4527 (release 7.6)	Domain	Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase (EC:4.4.1.4), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system. This family represents the  N-terminal EGF-like domain [1].	20.00	20.00	21.40	21.00	19.00	18.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.98	0.72	-3.98	6	87	2012-10-03 09:47:55	2003-04-07 12:59:11	8	4	21	7	34	96	0	55.30	63	12.67	CHANGED	hoWThKAAcEAEAVAAIsCSuHGRAaLDGlh.s-Gs.PhCECNsCYoGsDCSshlsNC	..........hoWoh+AAEEAEAVAsI.sCStHGRAFLD..Gll.s-Gs...PtCECNoCYsGPDCSp+lpsC.	0	6	24	30
+2391	PF01303	Egg_lysin		Egg lysin (Sperm-lysin)	Finn RD, Bateman A	anon	Pfam-B_1464 (release 3.0)	Domain	Egg lysin creates a hole in the envelope of the egg thereby allowing  the sperm to pass through the envelope and fuse with the egg.	21.00	21.00	21.10	21.10	20.60	20.60	hmmbuild  --amino -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.68	0.71	-4.11	24	77	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	40	11	2	85	0	88.00	52	83.19	CHANGED	ls+thEsAlKlpIlsuaD+cLspWlp+HGptl....oshQ+KTLaFVNR.RaMQTaWpsYhhahs++IttLG.RsssssDYsplGAcIG+..Rlshchh.Ysall++N...hlP+apsYMtclhup+suDlPl	.......ElAlKspIluGFD+pLspWLppHGptL....oslQ+KsLYFVNR.RYMQTah..a..h.......h........................................h..........h....................	0	0	0	2
+2393	PF00971	EIAV_GP90		EIAV coat protein, gp90	Finn RD, Bateman A	anon	Pfam-B_210 (release 3.0)	Family	Equine infectious anaemia (EIAV). EIAV belongs to the family Retroviridae. EIAV gp90 is hypervariable in the carboxyl-end region and more stable in the amino-end region.  This variability is a pathogenicity factor that allows the evasion of the host's immune response.	20.60	20.60	20.60	20.70	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.45	0.70	-6.00	3	1082	2009-09-11 14:56:58	2003-04-07 12:59:11	13	5	9	0	0	800	0	234.90	62	80.26	CHANGED	SKNSMAESKEARDQEMNLKEESKEEKRRNDWWKIGMFLLCLAGTTGGILWWYEGLPQQHYIGLVAIGGRLNGSGQSNAIECWGSFPGCRPFQNYFSYETNRSIHMNNNTATLLEAYHREITFIYKSSCTDSDHCQEYQCKKVN.......Nusph.sVsNTTEYWGFKWLECNQTENFKTILVPENEMVNINDoDTWIPKGCNETWARVKRCPIDILYGIHPIRLCVQPPFFLVQEKGIANTSRIGNCGPTIFLGVLEDNKGVVRGNYTACNVsRLEINRKDYTGIYQVPIFYTCNFTNITSCNNESIISVIMYETNQVQYLLCN.NNNSNNYNCVVQSFGVIGQAHLELPRPNKRIRNQSFNQYNCSINNKTELETWKLVKTSGITPLPIS	.........................................................................................................sF.sh.phtsNRsh.hsNpTuTLL-AYpREIT.IY+oSCsDSDHCQEYQCppVs..................s..s...................h.p..ss..p.s......o....s........E.....YWGFKWLECNQTENhKTILVPENEMVNINsssTWIPKGCNETWARVK+CPhDlLYGIp.IRhCVQPPFFLhp..pp.t..s.s.s.u.RIuNCGPTIFLGVLEDNKuslps...ssCplpphp.IpR.DYoGhYQlPIFYhCshTslpS.....................................................................................................................................................	0	0	0	0
+2394	PF01176	eIF-1a		Translation initiation factor 1A / IF-1	Finn RD, Bateman A, Mistry J, Wood V	anon	Prosite	Domain	This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.	23.00	23.00	23.00	23.20	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.04	0.72	-4.55	63	5916	2012-10-03 20:18:02	2003-04-07 12:59:11	14	9	5270	9	1627	2668	2074	65.40	52	77.15	CHANGED	cphph.GtVhchLuNuhacVphtsGpphLu+IsGK.h++plhIhtGDhVlVch.....psap..hsKucIsaR	..................IEhpGpVlEsLPN.uM..F+V.c...........L..........E....N..G..H.........h....l.L..AHIS.....GKhR....ppaI....R....ILs.G.D+V.pVEl........oPYD.....Lo+GRIsaR.......................	0	532	1008	1345
+2395	PF05091	eIF-3_zeta		Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)	Moxon SJ	anon	Pfam-B_6311 (release 7.7)	Family	This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery [1]. The gene coding for the protein has been implicated in cancer in mammals [2].	17.50	17.50	18.80	17.50	17.20	17.20	hmmbuild  -o /dev/null HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.83	0.70	-5.88	36	378	2012-10-11 20:44:43	2003-04-07 12:59:11	7	10	262	0	257	371	7	443.00	41	90.26	CHANGED	hshhhssl..Nss.uWGPspssp.....th.........slPatPFSKuD+lG+luDW.......sshp............................pts.shu.ssp.ash................ts-DEsoFplVD.....ss+ss....tpt+sp.....thsptsttpc.....................tthhsppttputt+cttthtp..........hst+.stt.p................t...hR-uSVplps-WshlE..ElcFscLsKLs.l.ss.cs-Dl..sshGpl.aYD+saD+ls.sKs.E+.Lpph.c.Rs.hassTTo-DPlIpcLhpcspu.........................................................sVaATDsILusLMsssRSlYSWDIllp+hG.sKlFhDK..R-susl....DhlTVNEs.A..s-sPh-.......s....pssINospuLuhEAThINpNFspQVlhpspp..phpacpsp.PFhscspc....................uShuY+YR+asLssp................lpLlsRsElDulhp...s..sscspals..l+ALNEaDsKhps.....l-WRpK.L-oQRGAllAsEh+NNosKLA+WssQulLAGuD.hKLGaVS.......Rsss+DsppHsILuspsaKPc-hAsQhsLshsNuWGIlRsIlDhsh+..pp-G............KYlLlKDPsKsllRLYpl	...........................................................................s.......l..s.s.uWGPsthsp.......th.................shPYtPFSKuD..+LG+..huDWos...ts.p..........................pp.s.th.u..ss...p.ash................tt.-DEsoFplVD........ss+sp.t......hh...tpt..ph..............t.ttp.p.t.tpttt...................t...h..tt.tpt.ttptt..thtp..............ttp..hs.ttt...........................t+...RcuSVplps-WphhE..Eh-FspL.Khp..h.........ps......s.....-spDl.................tphG......t.L.aYD.+saD+ls..s......+s.E+....Lp..p.h.p...Rh.hasV..TTo-DPlIpc.L...tcspu.........................................................sVFATDsILuhLMsssRSlYSWDIVl.+hG.sKlFhD..K..RDsuph..........Dh.lTVsEs.u..t-sP.-................ptsshNsspsLuhEAThINpNFupQslhtstp...+hph.psN.PFhpts.-.............................AShuY+YR+acLsts................lpLlsRsEhDuVhp.................ss...sspspals..l+ALNEaDs+hps.........sl-WRpK.L-oQR....GAVlAoEhKNNuhKLA+WTspAlLAsu-....hKLG.aVS.......Rhps+s.stpHlILus.taKPp-FAsQhNLshsNuWGIlRsllDhshc..........t..-G................KYlllKDPNKshlRlYp.............................................	2	108	152	212
+2396	PF01287	eIF-5a		Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	eIF5A, previously thought to be an initiation factor, has been shown to be required for peptide chain elongation in yeast [1].	21.50	21.50	21.60	21.50	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.03	0.72	-4.03	97	832	2012-10-03 20:18:02	2003-04-07 12:59:11	15	11	539	15	474	760	38	66.70	37	40.40	CHANGED	hVcRp-aQ.LlsIpsDs.......alsLMs.-sG-T+-DlclP..........pt...plscclcsta....csG.c-h.VsllsA.MGcEp...lhshK	.......VpRp-YQ.LlsIp.pDG.......aloLhs..-sG-o+-D..l+lP..............-s......pLspp.....Icsta.......spG..c-...lh.VsVhsA.MGcEthhshK......................	0	143	254	374
+2397	PF01873	eIF-5_eIF-2B	eIF5_eIF2B; 	Domain found in IF2B/IF5	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the N terminus of eIF-5 Swiss:P55010, and the C terminus of eIF-2 beta Swiss:P20042. This region corresponds to the whole of the archaebacterial eIF-2 beta homologue. The region contains a putative zinc binding C4 finger.	21.60	21.60	21.80	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.74	0.71	-4.46	13	1012	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	491	15	654	962	101	123.90	36	40.09	CHANGED	huh.....pNsctsssDcp..RachPthpstlEGp...tKTllsNhpDIAKsLsRsPp.alhKalhtELGosGslDup.sRhllpG+apspplpslLccaI+cYVlC+sCpsP-Tclh+c..sRhhhLcCcACGucss	........................hhp.....Nsp.sss-ph..RachP..p..s.hhEGp......hKTlhsNhs.-ls+s.................LpRssp......al............hcahhsELGsp.us.h.Dsp....sRhll....pG..pap.s.p.plpslLcpaIpc.YVhCtpCc.sP.-.TpLphc......sc...h..hhlpCcACGtp..s.........................	0	216	369	528
+2398	PF01912	eIF-6	eIF6; 	eIF-6 family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes eukaryotic translation initiation factor 6 as well as presumed archaebacterial homologues.	25.00	25.00	26.20	26.10	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.15	0.71	-5.23	65	564	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	471	8	362	545	94	190.30	51	82.10	CHANGED	h+hshtsss.pIGVaspsosshsLl.shssscphhshhcppLs....lsl.lcToIuGopllGplssGNpsGlLVPshspDpElp....pL+pph..slpVphlcp.+hoAlG.NlIhsNDpsALlaP-lsc-stchIsDsLsV.EVh+toIAs.shVGShuVhoN+GsLVHPcsot-ElcpLsslhp...Vs.lssGTVNtGoshlGuGllsNshus	.......................s.RspFE.sss-lGVFupLTNsYsLV..ulG.u.SEsFYSsFEuELst.hIP.l...l+soIu.GoRllGRhssG.....N+pGLLVPssTTDpELp....HlRNsLP...Ds................Vplp..Rl-..E.RLSALG.NlIsCN.DaVALV..HPDl-+ETEEl.luDVLsV.EVF.RpTlAspsLVGSYsshoNpGGLVHPcTohp-.-ELSsLLQ...VP.lsAGTVNRGSslluAGhVVNDash.....................................................	0	122	213	298
+2399	PF03608	EII-GUT		PTS system enzyme II sorbitol-specific factor	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	26.90	26.70	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.95	0.71	-4.41	17	904	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	809	0	76	276	63	163.20	64	89.76	CHANGED	alsphAEsFlsLFptGGcsFluhlTGIlPhLlhLLlAhNulIthlGEERlp+lAphuu+Nsl....hRYhlLPllusFhLsNPMshohGRFLPE+aKPuaYsuAspasHs.sGLFPHlNPGELFVaLGI........AsGlTp..LG......hssssLAlRYhLVGllhshl+GhVT-hhTsalt+p	.....h.IT+uAEWFIGLFQcGGEsFsGh.l..........TGIlPLLIsLLVhMNALIsFIGpcRIERhAQ+sAsNPl....SRYLLLPhIGoFhhCNPMolSLGRFhPEKYKPSYYAAAu...CHohNGLFPHINPGE.LFVaLGI........AsGlTT..LG.......LP.h.GsLAlpYLLVGLVsNFhRGWVTDhTTAhhpK+.............	0	22	38	61
+2400	PF03609	EII-Sor		PTS system sorbose-specific iic component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.37	0.70	-5.09	72	5167	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1519	0	403	1910	44	235.10	33	88.43	CHANGED	M...phshlQhlLlslluhlsshct....hh.sphthapPllsssllGLlhGDlpsGlllGuoLphhhLGh.sslGuAssPDsslAulluohlslt........ustsh.ssAl.ulAlPlAlhu.hLshls+....olsshhhHtuD+tAccGshpslphhphhuh.lhtulphulP.shl...slhhussslpshlssl......P...p..alhsGLsluGGhlsAVGaAhllphMss+..chhPFallGFllAua..h..pls...llulullG..hslAl.la	................................M...shlQhlLls.l.h.uh.l.u..s......h.ct......hh...sthth..ppPllsss....llGLll.....G....D....lpTGlllGuoLpLlhLGh.sshGu.A..h.sPDsshu...u.lluT.shult.............ss.h...ss....p....sAl...u.l...Al....PlA....s.h.sth....Lshlhp....ol.sshh.h.H.t.AD+...tAcpu.shpu.lp....h....hp.h.h.uh.hh...hu.l.h.h.ulP.shl...slhhG.sshVpshlssl......Pt....hltsGLslAGGhlPAlGaAhll.p.h.Mh.s.+...p.h.hPaFhlGFlhuAa...h.....pls...............llulullG..ss.hAll.............................................................................................................	0	104	225	318
+2401	PF03612	EIIBC-GUT_N	EIIBC-GUT; 	Sorbitol phosphotransferase enzyme II N-terminus	TIGRFAMs, Griffiths-Jones SR, Yeats C	anon	Yeats C	Family	\N	20.90	20.90	21.50	21.30	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.17	0.71	-4.67	31	932	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	811	0	85	414	65	167.90	55	52.77	CHANGED	pslcIsKGsGGWGGPLhltPstp+cKllYlT.GGscPslsc+IuELTGhEAVDGFKsulP.--ElusslIDCGGTLRCGlYPKK+IPTINlhsTGpSGPLApaIsEDIYVSuVpscsI.............................pls-u.susssspststptstsp.............asssKKlo-Qps......ullu....+lGhGhGpVlusFaQAGR-oID	.....................p.pl+IpKGsGGWGGPLpl.sspst+KlVYIT.u.GsRPsIVDKlApLTGhpAlDGFKpu.P.-sEIusAlIDCGGTLRCGIYPK+pIPTINlhsTGKSGPLAQYIsEDIYVSGV+.-.sI..................................slssc..sss.p.ss.s.ss...........................pc..............YDTSKKIT.EQsc..........GllAKlGMGhGpsVAVhaQuGRDoID....................................................................................	0	27	42	68
+2402	PF03611	EIIC-GAT		PTS system sugar-specific permease component	TIGRFAMs, Griffiths-Jones SR, Mifsud W, Bateman A	anon	TIGRFAMs & COG3037	Family	This family includes bacterial transmembrane proteins with a putative sugar-specific permease function, including and analogous to the IIC component of the PTS system. It has been suggested that this permease may form part of an L-ascorbate utilisation pathway, with proposed specificity for 3-keto-L-gulonate (formed by hydrolysis of L-ascorbate)[1]. This family includes the IIC component of the galactitol specific GAT family PTS system.	20.80	20.80	20.90	21.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.46	0.70	-5.70	89	5120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	1917	0	376	2362	24	393.50	26	88.73	CHANGED	lpslLs..ssulllullshlGhllh++shscslpGslKshlGFlhlshGsu.llssslsshsphhpcsaulps......sl.ss.....sulsth.........auotsuhlhl.luhllNllls...+hTph+hlaLTGchhhahushlsslhhhhsh.ss...............hhlllhuulllulhhslhsshst.hhpclTs..ssshuluHhs......sluh....hlushlu+h......h...us.p..ch......ssEshplPKpLuhhp-shlsssllhhllallss..............hh.......................t...h..................sspshhh...hlhtulphAAulhll.tGVRhhluEllPuFcGIuc+llPs...............uhsALDsslsasa.uPsAlhlGFl.uhhstllslhlh.......h.........hslIl..P..GhlshFFsuusuulFuNuh...GGh+GslltuhlsGllhhhlshhh.....hshlushts.................................................................................tsshhushDa	................................ptlLs..ssslllsllhhlhhllh+.t.phscslcusl+shlGF.hhlss.shu.ll.s.s.s.lsPhs....p...th....sc....sa.sl.ph......slsDshhs..usls...............au.o....hu.hhhl.luh.l.l.Nllhl....hT...p...hppl.Lsschh.hhthhlss.hl.hh.hsh...ss................hhhhlhuullhulhhhhhushht.hhpclhs......ssuhuluHhp.......sluh....hls.t.hlsph............h.......ss.h..p....c............sh...-...s...hcl...s+plu.....hat...-shhsssllhhllhhlsshs..........................................h.................................stp..hh....hlphulsh.Asslhll.psVRhh......lstlsPshpGlsp+lhsp..................hh.ulDssllhu...sP.sslhhGhl.......llslhll.....................hslIl..P...Gshsh...Fs..shs.s.hsa.s.ssh...uuhRGslhtshltG.ll.hhhlslhh.....sshhushth.......................................................................................................................................................................	0	98	214	302
+2403	PF03613	EIID-AGA		PTS system mannose/fructose/sorbose family IID component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	30.80	30.70	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.44	0.70	-5.46	125	5271	2009-09-11 00:44:58	2003-04-07 12:59:11	9	5	1544	0	416	2104	46	264.50	36	94.84	CHANGED	tpLTK+D....lppsahRuhhh.psuaNYERMQshGasauhlPsL+KLY....ts..c--htpAlcRH.lpFFNTpPhh.ushIhGlslAhEEccusss........hsstsIsulKsuLMGPLAGIGDolFasTltPIhuuluuulAhpG.sllGPllahllasll....thhh+ahthphGYchGsphlspl.tuuhl...pplocuAollGlhVlGuLlss.hVplsh...shp.hstsp...................................................................tshslQs.hLDplhPuLlPlhlshhsaaLLpKK...lsshhlllhlhllGllhshlGll	...............................cLTKcD.....lpp.lhhR..S.hhh..QsSa..NYERMQuhGasauhlPslKKlY.....ss....c...--......h...t.pAl++H.L.p.F.FNTpPal.sshlhGlslAMEEpcu....sss..............h.ttuIpulKsuLMGPLAGlGDslFW.hTlhPIh.....uu...luA..uh.A........h..........s.G....sl............lGP...l..l..FhllaNll....phhh+ahhhphGYchGsshl.pch....uuhl....pplocuASILGlhVlGuLlss.a.V.p.lsh.s.l..p...h..s.t.sp..........................................................................................p.s.hslQs.hLDplhPuLlPLhhThhhaaLL+KK...hsshhlIhshhllGIlsphlGlh.......................................................................	0	107	235	331
+2404	PF04873	EIN3		Ethylene insensitive 3	Mifsud W, Moxon S	anon	Pfam-B_4883 (release 7.6)	Family	Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence. 	21.40	21.40	22.00	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.44	0.70	-5.19	59	958	2009-01-15 18:05:59	2003-04-07 12:59:11	8	17	628	1	88	945	0	256.50	30	39.71	CHANGED	EE.lc++...-Qh.l+...+p+php.hhts+Ess....ssupKss.............+spEQhp++phScA........h.thclsNh.GFh.s.sssssK..phssssLp...+Eclcpsh.Gshtlus........pscsLlhusscs..ps...cpospssolphlsDTshG.QtS.SLLpAth.tptpssPppphsLptultsP.............cELhas....suKDppssstsaKcP...........LpstlpHh.p.s.hchccpthcophLQs..KhSpRpSFAhhus.sp.Ec.ssplhsc..ot....shpc....pSPclslpsspc.-sp......................sccEschp.cspshcsss...........................................shshssp+c.csu-.sphs.p....tlsthCpsoQhpus........-ochhhss+pulsQs.h	............................................-Ehcc.t...pph...l+...+tpp.p...hh...pp....................htspKtp..............................psp-phpcphhscs.....................h..hplsph.uhh.s...ppsc....hsssshp...t-.t.p.ph.tshthsp.............p.pphh.....uttps.........ttu...tshpl..l.-Tsh..s......Slh.s.h.....t.pss.s..p....phs......hh....sP.............pE.h.s.....spptt...........shcp............ht..t.lpp...p.s..chcc..hpophLQs..+hot+pohshhu..tp.p..shphhst......s...........s.pp....tus.psshp.s.t.p.c..-sp......GpcEsp..p...spshps.h....................................................s.hshsp.p.c.p..p.ssc.....shhs.p..th..shhC.t...s.t.h..t.t.p.-hphhh..sp.uhspp...................................................................................................................................................................................	0	10	42	60
+2405	PF03317	ELF		ELF protein	Mifsud W	anon	Pfam-B_3282 (release 6.5)	Family	This is a family of hypothetical proteins from cereal crops.	25.00	25.00	25.10	147.50	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.85	0.70	-5.11	2	19	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	18	0	3	15	0	252.30	77	96.73	CHANGED	MT.shhR.........hhFSo.St....Fpshhhphp.+h.hI.....shIhF..lCl....Fhh...IhhFlsh..IlLPIlphFu....sSFLITLPPElQDPQALAHLtGLNFYLSLYEQDPtWVsFIQpELNHNTPLEDIPGRL+LFLMEE+hSshR.DlIQEFlALYtR.GshLPlEPYLl-tALRSYLDpI+ATDsFolLQAuYQDLR-pEtGShFFRDsVSHNRDhLEApSutRphlEVEpp.hapcI.+upApLERsEapHsL.lFp.EDh+RthE	.MpNh..............VRWLFST.SR....FTsFYhahCIKFPhIY....shILFS.lCl....FhF...lsRFI.h..ILLPIhpLF.u.....uSFLITLPPEIQDPQALAHLAGLNFYLSLYEQDPGWVTFIQNELNHNTPLEDIPGRLKLFLMEEKLSSMRQDVIQEFVALYQRlGPYLPIEPYLVDEALRSYLDHIHATDSFTVLQASYQDLRENEGGSVFFRDAVSHNRDLLEAESSARRCLEVEQRIRWEEIPKSKASLERAEHEHALDLFKSEDLRRELE.	0	0	1	2
+2406	PF02323	ELH		Egg-laying hormone precursor    	Bashton M, Bateman A	anon	Pfam-B_953 (release 5.2)	Family	This family consists of egg-laying hormone (ELH) precursor and atrial gland peptides form little and California sea hare. The family also includes ovulation prohormone precursor from great pond snail. This family thus represents a conserved gastropoda ovulation and  egg production prohormone.  Note that many of the proteins present  are further cleaved to give individual peptides [2]. Neuropeptidergic bag cells of the marine mollusk Aplysia californica synthesise an egg-laying hormone (ELH) precursor protein which is  cleaved to generate several bioactive peptides including ELH,  bag cell peptides (BCP) and acidic peptide (AP) [1].	19.60	19.60	21.00	20.50	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.68	0.70	-5.23	4	25	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	7	0	1	41	0	116.80	44	91.91	CHANGED	Mp+Ps.tssssh..llhCLhLSoLCsSSpSsuVHG+sFsspRAVK.pus.lV.SstD......stN.......-t.-csst.h.sss--..psEKpRLphtKRRlRFs+R..c.uth+.h.hpthshSADEN..FDLSN-DGA..QRchRsPRLRFYslRKRAAGs.EpSEspNPETESH...SRRKRSsLT.PSlpSLtpSLESGISKRISINQDLKAIsDMLLsEQhptRcRhLAsLRQRLL-hGKRuSs....VuLhsu-ht.-tRph	.........p..............................................................................................................................................................ltK+...t.ptuEt.p.p.cS....Shp.RSh....s.PS......pu.E.th.K.ISIsQDlhs.sp..h.tpht.Rpp..tsLhphhhph............................................................................	1	1	1	1
+2407	PF00964	Elicitin		Elicitin	Bateman A	anon	Sarah Teichmann	Domain	Elicitins form a novel class of plant necrotic proteins which are secreted by Phytophthora and Pythium fungi, parasites of many economically important crops. These proteins induce leaf necrosis in infected plants and elicit an incompatible hypersensitive-like reaction, leading to the development of a systemic acquired resistance against a range of fungal and bacterial plant pathogens [1].	25.00	25.00	25.10	26.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.96	0.72	-4.04	87	406	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	40	16	173	325	0	89.40	32	49.01	CHANGED	ssCossp.......lsslhsss.h...ssCu.....pss.s.hshhs.s..sossphtshCsuosChsllsslhshs..sD..C.....slshsu..hshpphlsshhstCs	........................sCosop....hsslsslLosssh...spCu.....sDS..G....Yshlss.s.s...h.PTssphphMCuSou.Cpshlsplhuhss..PD..C.....slsh.uGhhhNlhphssshtspCs.............	0	59	101	173
+2408	PF03789	ELK		ELK domain 	Finn RD	anon	Pfam-B_3136 (release 7.0)	Domain	This domain is required for the nuclear localisation of these proteins [1].  All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox Pfam:PF00046. 	21.30	21.30	21.40	22.10	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.33	0.73	-6.39	0.73	-4.00	28	1671	2012-10-04 14:01:12	2003-04-07 12:59:11	8	7	111	0	131	525	2	22.00	75	11.86	CHANGED	ELKcpLh+KYuGaLusL+pEF.	.ELKDpLLRKYSGYLSSLKQEFh..	0	14	79	110
+2409	PF01151	ELO	GNS1_SUR4; 	GNS1/SUR4 family	Finn RD, Bateman A, Kerrison ND	anon	Prosite	Family	Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and  sphingolipid synthesis [1].  Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum.   Yeast ELO3 (Swiss:P40319) affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1 [2].	21.00	21.00	21.50	21.10	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.99	0.70	-5.08	181	2001	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	384	0	1301	1987	48	227.10	27	79.46	CHANGED	hhhss.h..shhlhshYlh...hV.....................hhGs.chMc....sR..c.......Ph............................pL+thhhlaNlhlslhShhhhhthh........t.hshh..h...........................................uhaphhC...............................................s.tthtts..hssaah..a.lSKhhEhlDTlFhlL+..........KK...ploFLHsYHHsshhhhsahshphh.suu..thhhh.hlNshVHslM.......YhYYhls..uhu...........h+.h..ha..KcalTphQllQFllsh.hhshhshhh....................................................................................................................sC........hh.shhhsh.......hhhhoalhLFhsFah.psY..h+pp....ptp...p	.............................................................................ts.h.sh.hhhhhYlh...hl......................hhG..c.hMc..............sR.......p......Pa......................................pL+t.hhhl...aN...hhhslh....Shhhhhthh..................hhthh..............................................shaphhC.................................................s.t.tht.t..hhhh.h..h..h........ahhoK..hhEhhDTl..FhlLR.................KK......ploFLHsYHHsshh..h.h.s.W..........hs.h...p...hh...su.u............t...hhh...h.hlN..hVHslM..........YhYYhlu....uhu...........hp...hhW...Kcal..TthQllQFllsh..hhshhshhh.........................................................................................................................sC...........hhhhhhhhhhhshhhLF.hpFahpsY.hpttt...t........................................................	1	477	666	1080
+2410	PF02488	EMA		Merozoite Antigen	Mian N, Bateman A	anon	Pfam-B_924 (release 5.4)	Family	This family represents the immunodominant surface antigen of Theileria parasites including equi merozoite antigen-1 (EMA-1) and equi merozoite antigen-2 (EMA-2) [1]. The protein shows variation at a putative glycosylation site, a potential mechanism for host immune response evasion [2].	36.00	36.00	43.70	94.20	33.00	35.10	hmmbuild  --amino -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.62	0.70	-4.90	10	417	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	56	0	2	413	0	240.60	65	91.16	CHANGED	K-cKcDLslDVshoSh-NVTlsss...-AsslVhTA+-GaRFKTLKVGDKTLYsVDTSKaTPspsa+LKHs--hah+LsLcsApPlhFKKKGDKEWsEhcaAsYYD-VLFKGKpt.K-LDsSKFsDsuLFoossFGoGKKaTFpssFK.sSKVsF-cK-VGcscpAKaL-VhVYVGuDsKKVVRLDYFYsGDuRlKEVYFcLtD-KWs+lEQs-ANKsLHAMsooWshDYKPlVDKFSPLAVhuuVLIVuuuslYa	.t.EEKKDLsL-VsATpsENhTVsso...suNcVVaTAp-GaRF.KTLKVGDKTLYTVDTSKFTPTsAaRLKHs--LaFKLsLppAKPLlFKKKoDK-WVpFsFupYLDEVLWK-KK-.K-LDASKFsDA.uLFsu-AFGTGKVYsFhGsFK.lpKVhFEcK-VGDssKAKYTuVKVYVGoD-KKVVRLDYFYTGDERFKEVYFKLVDsKWK+lEQSEANKDLHAMNsAWPhDYKPlVDKFSPLAV.....................	0	0	1	1
+2411	PF01105	EMP24_GP25L		emp24/gp25L/p24 family/GOLD	Finn RD, Bateman A, Wuster A	anon	Pfam-B_803 (release 3.0)	Domain	Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains.  This domain corresponds closely to the beta-strand rich GOLD domain described in [2].\	 The GOLD domain is always found combined with lipid- or membrane-association domains [2].	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.10	0.71	-4.57	232	2288	2012-10-03 07:10:23	2003-04-07 12:59:11	19	33	357	5	1454	2124	14	176.60	21	79.83	CHANGED	uhphplsss...ppc..Ca....h-pl..pp.sshlthpapl......sss...............................hslshp.........lp.....t.......ps....p.....hlhpp.ptp..pt..t...........pasFsu.p...................................psG.pYph.CFpsp.sphtt...............................ptlphclph.......s..tt..........................htp......hsp..ppclps..lpp............................plpp.......lppplpplpppppah+tREpph+sts-usspRlhhaSlhplhlllshuhhQlha..L+paFp	...........................................................................................................hhh.lss...t....ppc....Ch....hcpl.........tp..ss..hlh..h...p..apl...........pts....................................................t..hslshp..........................lp..................................ss....tp.....................hlhpp..ptp..st....s.........................pas..Fsu..p..............................................psG...p...a.ph.CFpsphsshst...............................ppVp.hclph................u...pt..p..................................................................htp........htp........ppclps..lpt.......................................................................p.l.pp............lpptlpp..lpcp...ppah+t.R..EtphRsts.......EssssR.Vhh....aSlhphhlllshuhhQlhhL+paF...................................................................	0	470	751	1133
+2412	PF04493	Endonuclease_5	Endonuc_V; 	Endonuclease V	Bateman A, Wood V	anon	Wood V	Family	Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents [1].	20.00	20.00	20.30	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.19	0.70	-4.98	14	1175	2012-10-02 11:25:59	2003-04-07 12:59:11	9	7	1072	10	386	811	48	194.60	45	85.13	CHANGED	h.p-lpp+lshpsphpp..ph..chlAGVDlua....cpscuhushVlhshsshcllcptsh.hsclshPYlPGFLuFREh.hhlthlcpLtpc.c......................llllDGpGlhHPR+hGlAoHhGllLshPTIGVAKphLps....shhp.pst.........sshp.lh......suphhGtsht.ohpsspPlalSsGsphslcsslclspphhps.h+lPcssR.ADhho	.........................................plt.pp.l.hp.s.ph.s.....t........ss..phluGsDVuFc........psG-lspA.A.hVl......L.c.....a.....P.....o............L.........-.l.V.EhplA...cl..sso..hP.YIPGFLSFREh...PuLLsAh...c....t....L....s....p...+...P.D......................LlhVDGp....GIu............H.P.R...R......h.GlAS..Hh..G..lLl..D..l..PTIGVAKp+LsG....capslssc..............................................Gu.hsP.L.hc...............cGEp.lu.....hV.hR.....o.......+.......s............p.........s..p.....P..........LFlusGHRV.Sl-............oAlshVp+Chps..YRLPEPTRh.ADth.u......................................................	0	138	250	323
+2413	PF02945	Endonuclease_7	endonuclease_7; 	Recombination endonuclease VII	Finn, RD	anon	Structural domain	Domain	\N	23.60	23.60	23.80	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.62	0.72	-4.27	16	283	2012-10-05 18:28:12	2003-04-07 12:59:11	10	5	233	14	41	269	148	84.50	31	34.34	CHANGED	tp+htthYsl....ohccht.tlh-tQsG..pCtl..Cp....s..tpsh....slDHDH.....csGh.........VRGlLCssCNp.hlG+..h................tDs.chlpp..hhsYLcs	............................t...........pph...tlhptQ.........su...pCsl..Cpt.........ht...t..tp.ph..................slDHDH..........pTGh...........VRG.lL..CssCNt.sl.Gph...............tDs......phhpphhpYLp.t...................................	0	8	21	40
+2414	PF04231	Endonuclease_1	Endonuclease_I;	Endonuclease I	Kerrison ND, Finn RD	anon	COG2356	Family	Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species.  It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown [1].  Other family members are known to be extracellular [2].  This family also includes a non-specific, Mg2+ activated ribonuclease precursor (Swiss:Q03091) [3].	25.00	25.00	26.30	26.00	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.59	0.70	-4.51	55	1440	2012-10-05 18:28:12	2003-04-07 12:59:11	8	32	1199	11	288	962	273	210.20	40	70.17	CHANGED	pohpphK.pLts...................psY..s...........................sss.hshYsGsshstp...........pu..sppsps..........schphEHV.......hPtpphupppp....................................pthpu.DlHpLhPssGpVNusRuNasFu.hs.................sss......phGpsshtssa.......cscphEP.cp.s+GslARshhYMstRY.s..............lclsctpp...............plhttWs+p.PVssaEppRNptIhp.hQGN+NPFl....spsp	........................................................t..t.hhhhh................................................................ps....css.....ss.hY..CGsphshpsp........thscht...sCGY.p.s.R.KspsR..........usRlEWEHV.......VPA.pFG+pppCWpp......G...............GR+sCtp....s..appM-o.DhHNLpPul.GE.....VNGDRuNa..au.phs.....................sGt......pYGp...Cs...hplcF...............Kp.+tsEPssc.s+GsIARsYFYMpspY..s.....................LpLSc.pps........................pLhpsWs+p.aPVos.WEp..cRs.....p........+Itc.......lQ.G.N.+.NPaVpcsp................	0	90	164	237
+2415	PF04667	Endosulfine	endosulfine; 	cAMP-regulated phosphoprotein/endosulfine conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4454 (release 7.5)	Family	Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19.  Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism.  In both cases the region occupies the majority of the protein [1,2]. 	29.80	29.80	31.20	30.00	29.70	29.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.95	0.72	-4.02	12	485	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	254	0	291	440	0	86.40	28	63.05	CHANGED	slshuphp.pE..............+lhKhYGtLsspKsh........Lp+Khpc.RKYFDSGDYAhtKuts.pspt....s.tt.t..hssssthccshh++thsuSss	.....................................................t.......p..-Et................+..lhthY...G.pL...ssKtsh..............................................Ltp+hpc...+KYFDSGDYshuKAtht...s.pphs..........................................ss....................................................	0	71	139	223
+2416	PF00322	Endothelin	endothelin; 	Endothelin family	Finn RD	anon	Prosite	Repeat	\N	20.50	20.50	25.30	20.50	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.73	0.72	-4.71	8	186	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	53	9	79	193	0	29.50	68	19.48	CHANGED	Rsc.hCSCsshpDKEClYFCHLDIIWhNTss	.....Rs+.RCSCsohhDKECVYFCHLDIIWlNTPp....	0	3	9	26
+2417	PF00555	Endotoxin_M	endotoxin; 	delta endotoxin	Bateman A, de Maagd R	anon	Arne Eloffson	Domain	This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.	25.00	25.00	28.80	27.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.47	0.71	-4.49	36	401	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	48	8	1	429	0	200.00	30	21.33	CHANGED	TpspLTRElYTDPlstss................sshs....oFsslEsshlRsPHLh-aLsplplaTst.pt........hpaWuGpplphphots....shlppshaGsps..stsstsls....ssps....lYRshopsh..h........ssshtulptspFhhssspttthssshhp......sss..shDohspLPspssp.........s.hpsYSHpLSalphhttphsp.t........hPsauWTH+Ssc	.........................TsoQLTRElYTsPlhtshst................psh......ohpslEsshl..RsPHLhDhLsp.lsIYT.st.pps............htaWuGHplthp.sss....sthshshaGshss..stssppls....hsps....lYRThSss..hh...th...........sp.ltslstscF..th....sss..thssshYt............tss....shDShsclP.Pp.s.ss.........Ps...h...puaSHRLSHlsh.hpts...tss.............sssF......uWTH+Ss-...................................................	0	0	0	0
+2418	PF03944	Endotoxin_C	endotoxin_C; 	delta endotoxin	Bateman A, de Maagd R	anon	Arne Eloffson	Domain	This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.	21.00	21.00	21.40	21.40	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.98	0.71	-4.07	80	512	2012-10-03 19:46:52	2003-04-07 12:59:11	9	13	62	9	5	538	2	134.80	32	15.34	CHANGED	ITQIPsVKuhpl.t.s...susVlcGPG.aTGGDll.hpssssh......hphpls......sshsppY.+lRlRYAS.ssshphtlphssssh........shshssThss.....st.....hp..Yp.sFphhshss......shsh.sssp.tplpl......thpshsss..splhlD+IEFI..Pls	................ITQIPh.lKu.tl..s...s.....ssoVlpG.......PG.aTGGDllphpsssst............uplpls.....p.sshup+Y.RlRlR...YA.S...s.ss.....hphplshsspshs........phshssThs..s.....sss........lp....hs.s..Fphhshss........shsh..ssss....hsl.......shpshsus...splhID+IEFlPsp...................................................................	0	2	4	4
+2419	PF03945	Endotoxin_N	endotoxin_N; 	delta endotoxin, N-terminal domain	Bateman A, de Maagd R	anon	Arne Eloffson	Domain	This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.47	0.70	-4.96	38	632	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	108	9	79	668	0	213.70	28	25.79	CHANGED	lpsulslsuhlLush.h..PhuGhlhuhht.LlshlWPstsss....WchFlpplEpLIc.Q+Ischs+spAlucLpGLsssac.....hYhpuLcpWcpsssssps......pptlcppFpsh-sthpsulPtFslp..sh....p...lsLLslYAQAANLHLhLLRDuslaGp.cWGhspssls.......paYsc.hchhpcYosHClpaYNsGLspL+.........sos...hpsWhcYNpFRREhTLsVLDlVALFPsYDsRt	..................................................................................................................h...shslsthlLu.h..h........P.h...sG.h.l...h.s..ht.llshlW.....st......tsss..........Wc.thhp.plEpl...Is....Q+Ipp.hsp....spshucL....p.G.Lpshhp....................Yt.pshcp.W..p....ss.ssss......................tptlpppapshpst.hhst.l...P....Fthp....sa.............p.........l.LL.slYsQAANLHL.lLRDs...laGp..cW...G...hs....sssls.............................shhs.c........hpphhtpY.osas..lp.hYssGLpplt...............................tss....tpWhpa........s...p...aR+phTLtVLDllul.F.s.YD...t....................................................................................	0	46	71	76
+2420	PF03272	Enhancin		Viral enhancin protein	Mifsud W	anon	Pfam-B_4236 (release 6.5)	Family	\N	19.50	19.50	19.60	19.60	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	775	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.10	0.70	-6.62	14	631	2012-10-03 04:41:15	2003-04-07 12:59:11	8	24	223	0	27	514	0	333.10	25	62.04	CHANGED	hs.hsltlPslshPsWlpsss.shhulcHt+pPlshlltAushl+lRpsps........lTlclLNsscpTEcolss..sss.hphssptsSVsFVcpsh.sstssthc..VpaplsuphpsLPhYphGpsp..t.Fhsphs..spsssaual-hchlplLVP.sD+stlp...ttshslspLtsaYssIlpaYssLsGh........sptNh.s++YFsKADt.uGsGuAYYuptahApSssolp.haLpsossNWhsLHEIGHuY-htFs.spthht..EVWsNlhsDhaQYthhs.sE+.ppuhlYpsGp+spl-psIhshlsssh.sassWshhp+Lhhho.lh.ppuGcchhpphppphRph.pshshs.ppaplhshlssh.....sphDls.hhpLh.th..s.........................thp.tshhhtppshYPlppllssa-hht.....l+....hposasLVsssphht.....sslolphpIc-ss.......QIhGphhtlhcGschlhpsslssssphhhs.tlssGlYplhhPpGp.s+RYpls..............spYllVcsss.p.........hplpap.hstSslhsc.phplhGhsD.tlsAshhlshtpcplslplhsssPpstFsNphYaplsIcsssshph..hsh.t.sss..tpshhshch..ssshplhlacpcsspph.....ahssh.ss.psssahloppGlpptss.....ssttpplhs+IsphstaLsscsshLh.hpspl+DsIYLuhphl.sppp..ptLhppascalP....ph.ss.......pshshshhGhsphshlplphshshppsplhhtss.s.....t..hp.....Yhslph	...................................................................tphs.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................phphpGhuD.hphApls.h.spppc.c.hplslp..s..s..pPHsYFss..pYuoIpVhsps..Gphlap+chpG..s.ppp.ts.p.pp.hshp....sshplp.....laH.....sEs.t....Rlph.......shtsph.ppp.....Kpt..h.ap..lTppG.Lcp.p........................................................................................................................................................tp.............................................................................................	0	0	8	14
+2421	PF03386	ENOD93		Early nodulin 93 ENOD93 protein	Mifsud W	anon	Pfam-B_2931 (release 6.6)	Family	\N	25.00	25.00	33.50	26.60	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.65	0.72	-4.27	8	99	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	28	0	48	83	0	75.50	65	70.20	CHANGED	QKhAhAKpCS+EushAGsKAAAVAsVAoAlPTLASVRMlPWAKANL.N.TAQALIISoAAGhAYFIsADKTILusARKpS	.........Q+lAhAKcCS+EuslAGsKAAAVAolASAlPT.........LASVRMLPWAKANl.N.TuQALIIoTsAGhAYFIsADKpILuhAR+pS............	0	3	24	36
+2422	PF00113	Enolase_C	enolase; 	Enolase, C-terminal TIM barrel domain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.72	0.70	-5.45	11	7258	2012-10-02 01:07:48	2003-04-07 12:59:11	17	14	5866	108	1661	5284	3499	256.00	52	66.97	CHANGED	shlLPVPhhNVlNGGSHAGNcLAhQEFMIhPoGAsSFsEAhRhGuEVYHsLKullKtKaG.sAsNVGDEGGFAPNIpoNcEAL-LIs-AIpKAGYpG..KVpIuMDVAuSEFY..c-sKYDLDFKs.psc.S+hlou-pLsDhYcElspcYPIVSIEDPFDpDDW-uWsphTtphGpclQIVGDDLTVTNPKRlpcAIEcKssNuLLLKVNQIGolTESlpAschApcAGWGVMVSHRSGETEDoFIADLsVGLssGQIKTGAPCRSERLAKYNQLLRIEEELGupAhYAGcsFp+sh	...................................................................................................................p.hhLPVP..hhNlING.GsHA.s.N.s.l.s.h.Q.E..FM.Ih.Pl..GA...p.oFpEAlRh..GuElaH.s.L.Kp.lL..........K..........p..............+G................h.........sT..u............VGD...E................GG................FAP................s.l.........t.........s.........s...............c.-...............A..L.phIh.c..AIct...AG..YpsG............pclhl.......uh....DsAu.S.E....F..Y.............c...s.....G.....p.....Y.......s.h.....p.......t....c...s.........................................................t..hh........o................upchscahpp.Ls.p....c.Y....P....I.lS.I.EDsh.......sE....sD..W-GWthhT......pp.l...G.......p...+...lQ................lVGDDLF....V.TN.s.c.hL....t..c..G.I.c..p...t.....hu.Nul...L.....lKlN..............Q...IGoLTETlpAlchA.+c..sG...a.sshlSH.R....SG..E..T..EDo..hIA..Dl.AVuhssG...QI..KT.Gu..uRo-RlAKYNQ.Ll...R.IE-t.L...u..p........A.........a...G.t....h..........................................................................................................................	0	546	1007	1367
+2423	PF03952	Enolase_N	enolase_N; 	Enolase, N-terminal domain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.10	21.10	21.40	21.70	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.46	0.71	-4.22	190	6649	2012-10-02 11:54:41	2003-04-07 12:59:11	11	15	5507	108	1614	4840	2520	125.70	58	30.79	CHANGED	pIpplpAREILDSRGNPTVEV-VhhpsG.hG......RAuVPSGASTGppEAlELRDuD.....p+ahGKGVhcA......VpNVNshIussL.l..G.hc....st-QptlDphhl.cLDGTp.....NK..u+LGANAILuVSlAsA+AAAsshs.lPLYcYl	.............................................................IhclhuREllDSRGNPTVEs-Vhh...-....s.G....h..hG....................RAsVPSG..AS...T....G...p..........+EA.l...E..LRDGD....K..............sRYhGK.GVhKA..............VpNVNshI...Ass.l..l....G..hD...............sp-Q..ttID.phMI.c.LD...G..Tt........NK.....u+LGANAILGVS.L.....AlA+AAA.sttslPLYcYl.......................................	0	524	978	1328
+2424	PF03735	ENT		ENT domain	Bateman A, Hughes-Davies L	anon	Bateman A	Family	This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts  with BRCA2. The N terminus of this protein is found to be  similar to other vertebrate and plant proteins of unknown function.  This domain has a completely conserved histidine residue that may be functionally important.	20.70	20.70	20.70	22.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.12	0.72	-4.25	20	289	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	104	5	169	275	23	69.90	40	10.89	CHANGED	hcsp..l+pLEp-AYuuVL+AF+AQus.lSh-Kcplls-LR..................KELplSs--HRphlp+lssD-plpplRctppusss	..........ct.l+pLEhEAYsuVlpAh+AQu-..L.ohEKcsLlsELR..................+pLpI.SsEcHRt.lp+sssD-hlppItc.hts...s...........	1	42	89	127
+2425	PF01375	Enterotoxin_a	Enterotoxin_A; 	Heat-labile enterotoxin alpha chain	Bateman A	anon	SCOP	Domain	\N	19.60	19.60	19.90	20.10	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.63	0.70	-5.09	6	164	2012-10-01 23:25:29	2003-04-07 12:59:11	12	6	82	29	50	164	0	208.20	43	47.94	CHANGED	hsplhhFFI...hlu....ANs..haRADSRoPDEl+cSGGLhPRGpsEsa-RGTslNINLYDHARGTsTG.sRasDGYVSTohoLRpAHLhGQshLuuascYYIYVlAsAPNhFDVNGVLGs.YSPaPsEsEsuALGGIPaSQIhGWYRVs....FGsl-st.hcRNR-YRc-hacsLssAPupDGYpLAGFPssaPAWcEtPWtpa.AP.uCssss+ppssssCsptsspLupttLt-app+lKRplshh..hS..ps-hhusssh+DEL	.....................h.......................t...lYRu.D.s.RsP--I+puG..GhhPR.......Gpschh.p.cs.Tph...sh.......sLa-..HspGs..ps..........GhsR...h.s.D.GYVSTo......ho...lc.s.A..+..h.hu.p..s..hlu...s...hs......s......h..YIYsI...A.s.A..PN.MhsV............N...c....s...L......Gs..Y........SP..aPt.EpEhuALGGIPaoQIhGWYRVp...............................aG.sl-p.....t..hp+NctYcs..ch.a.pshs.h.Asuts...tLAG.FPs...pa..AWc.-cPWhpa..us.ss.t.p.t....c.s...sssCsttppphs.h.h.phpphh+.p..................................................................................................	0	3	37	40
+2426	PF01376	Enterotoxin_b	Enterotoxin_B; 	Heat-labile enterotoxin beta chain	Bateman A	anon	SCOP	Domain	\N	25.00	25.00	80.60	80.50	21.30	19.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.57	0.72	-4.16	5	107	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	28	276	1	108	0	95.80	92	83.02	CHANGED	TPQNITDLCAEYHNTQIYTLNDKILSYTESLAGKREMAIITFKNGATFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMA	.TPQNITDLCAEYHNTQIaTLNDKIFSYTESLAGKREMAIITFKNGATFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPpuIAAISMt.	0	1	1	1
+2427	PF02048	Enterotoxin_ST	Enterotoxin_HS;	Heat-stable enterotoxin ST	Mian N, Bateman A	anon	IPR001489	Family	This family consists of the heat stable enterotoxin ST from Escherichia coli. ST is a small peptide of 18 or 19 amino acid residues produced by enterotoxigenic E. coli and is one of the causes of acute diarrhoea in infants and travellers in developing countries. ST triggers a biological response by binding to a membrane-associated guanylyl cyclase C which is located on intestinal epithelial cell membranes [1].	21.10	21.10	23.10	22.70	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.23	0.72	-3.71	6	34	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	13	3	0	35	0	45.90	57	76.04	CHANGED	QETsShphuDu.SssIssEl.cKtCDs.psss....Es.sDW..CCElCCNPACAGC	..................................KtpIsh.s..ccCsh.Kpss....EshNsh..CCElCCNPAChGC	0	0	0	0
+2428	PF01417	ENTH		ENTH domain	Bateman A	anon	[1]	Domain	The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery.  The function of the ENTH domain is unknown.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.49	0.71	-4.26	72	1127	2012-10-02 18:21:09	2003-04-07 12:59:11	15	25	307	14	691	1760	5	121.20	40	23.47	CHANGED	hophphcVR-ATss-.sW.GP..osshhp-IuchTas..pph.clhshlh+Rl.........................................................s...cps+pWRplhK.........uLpLL-YLl+sGSE.....pslpph.+pplhhlpsL.ppFpa.h-p.pG+DpGhs............lRp+ucplhsLLpDs-pL	................................................................ophphKVR-ATs.sD.PW..GP.ou..s.l.M.s....EI.....A.....c.h...T........a......s.....h.....ts........a.t..E......I....Msh...la...+...RL............................................................p..-puKsWR+lYK..............uLpLL-YLl+sGSE........+V.s.p.ps...+c..s...l...a....h....I..psL....c..........sF....pa.lDc..pG+DQGhN............VRp+uKpllsLLpD--+L........................................................	0	203	350	539
+2429	PF00429	TLV_coat	ENV_polyprotein; 	ENV polyprotein (coat polyprotein)	Finn RD	anon	Pfam-B_145 (release 1.0)	Family	\N	22.50	22.50	22.60	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	561	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.24	0.70	-13.00	0.70	-6.06	16	3200	2009-01-15 18:05:59	2003-04-07 12:59:11	14	13	221	9	70	2514	0	268.00	25	83.52	CHANGED	llLhlLhh.........ht.ssP+pshslh.plhs.................phhP.h......shCsLuut..sshshsspss.sss..s.spsuhhss...............p..Csps.ph......stttstshYlCPspspsh..stpphGh.pssYs..sthtCppsG.....psYWpss.ohsh.olppsto.....................ttspssptpstsssLhlpFopsGppu....pshsWuhR..lahS.GtsPhhhhslphhhppl........p.lltpp.tPPsp.pPht.Phss......................................t.ssssphlsLlpusa.sLNhTsPshsp-CWLCLstu..PPaatulus.sshsspTsss....C.ssspatLp.spsos.shhhu.......sl.....PhsatshsN............ps...tttss..hLssssGohasCssshT.ChpTsl.NhooshClLspLhPclohhss-....l.s..psssRh+Rt.slulTLs.LLsGL...GIuuuluTGsTuL.Vu.....sppappLpttlcsDlptLppoIssLccsLsSLuEVVLQNRRGLDLLFhcpG..GLCtALpEcCCFYAs+oGlVRDphtKLpE+LppRp+lhpupthW.pGhhshSPWhpsLlpohhGPLllLLLlLhFGPCILN....+LspFl+	...........................................................................................................................................................h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ph.thtt...tpp......................................................................................................................................................................................................................................................................	0	14	16	49
+2430	PF00811	Ependymin		Ependymin	Bateman A	anon	Pfam-B_1391 (release 2.1)	Family	\N	25.00	25.00	26.20	25.30	24.20	24.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.67	0.71	-4.45	20	196	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	88	0	108	182	0	130.50	28	57.16	CHANGED	lEcssphNpopph.DlLlhFcE..GVhY-IDt+NcoC+KpsLppph+Ph-lPssATa.sEhhlGussh.tpGLcVchWsGc..lP-p+........GpYohpoTphGClPVops.Yps-ps...s.LhhSFa-lpstlcDP.pVFsPPu.hC	................h.........stph.-hlhhac-..GlhYpIs.pscpCpKpsL..p.p..sa...cPhclPpsAoa.....sphhlGus....tpulhVppWssc...hsstp........utY...s.s.p..s.s..s....ClPVpps...ahs....sps...........shlh..h..p..Fhslph..GIpDP.sVFsPPs.hC...................................	0	61	68	92
+2431	PF01404	Ephrin_lbd	EPH_lbd; 	Ephrin receptor ligand binding domain	Bateman A	anon	[1]	Domain	The Eph receptors, which bind to ephrins Pfam:PF00812 are a large family of receptor tyrosine kinases.  This family represents the amino terminal domain which binds the ephrin ligand [1].	19.80	19.80	19.80	20.60	18.70	19.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.49	0.71	-4.48	33	1131	2012-10-03 19:46:52	2003-04-07 12:59:11	14	44	89	57	480	825	1	167.20	52	19.47	CHANGED	EssLLDopsspu-L.GWhsaP.s.G.........W-EloshD.-ptpslRTYQVC..sV....hcssQNNWLRTsaIpR.psApRlaVEl+FTlRDCsShPusss..oCKETFNLYYhEoDp............sss...sshpcstatKlDTIAADEu.hsphc...........hssps.h+lNTElRslGP.....Lo+.+GFYLAFQDhGAClALlSVRVaYK+C	...............................................sLhDopt.t.u-L......uWhs.P.p...G...................WEElSthD.E.phssIRTYQVC..NV.......h-.ssQNNWLRT...saI.sR....cuA.p......R.......lalEl+FT...l.R.DCsS..lP..ss...h..G.....o....CKE..TFNLYYhEoDp...............s.ts....sthpEs.a...........hK..l....DTIAADES.FophD....................hGsRh.hKlN.TElRslGP................Lo+.+G..FYLAFQ.DhGAClAL.lSVRVaYKKC.........................................	0	50	89	238
+2432	PF01370	Epimerase		NAD dependent epimerase/dehydratase family	Bateman A	anon	Pfam-B_93 (release 3.0)	Family	This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.13	0.70	-11.31	0.70	-4.93	96	38903	2012-10-10 17:06:42	2003-04-07 12:59:11	16	146	5462	329	11522	75709	43322	233.20	20	69.25	CHANGED	lLlTGssGhlGutlschLhppuhc.........shshtppts..........................h..sDls.cpsslpchhppt...psDt....VhphAAtst...lttsh.ppstthhcsN....hhsshpll-uhp.........phsh.........h+hlhsoS.uplYGps..tt.....................h..sEsssh...tPhsP....YuhuKhhupthstsh......pcp..a.shpssshhhhNhhGPt........t.tthss+hlsthlpphh..........pup..................................lhhhG.......sGss.tRDalascDhscAhhhhlppsp.............spsaNlG	........................................................................................................................................lLlT.G.u..s..G...a.......l...G......u..p...l....s......p..t....L......h..p......p....G.hp......lh...................shs..t.s..t..p..t..t.......................................................................th.p.h..h.......s...D.....l......p......c.........t.......s.........t......l.......p.....p....h....h...p...pt........................D..s.......................V....h.......H..........h.........A........u......................s............h..........s...........t...........t..........s..........h........p..............p........s..........t.........t.........h.......h.....p.....s....N.......................l...h....u....o....h.....s........l.....l........c.....s....sp............................................................p.t.ss..............t+..h..l...a...s....S.......o.....s........s......l........Y...Gps.........tp.h....................s................................................................h.....s.E...s.psh............t.P.h.ss.....................................Y..u...h.....o....K..........h....h....s..E.......p....h....s...p...s...h...............................t...c...p......h......s.........h.....p........h.......s....h....h....R....h....h...s...s....h....Gst.......................t......s...p...h...l.....s....h...h...h...p...t..h...h.......................................................t.s.p....................................................................hh.l.h.G............sG.....p....t.....h....R.....s..........a....l......a..l.pD...h....s...pu.h..h....h....h..h..p.p.t....................t.hsh.........................................................................................................................................................................	0	3673	7370	9810
+2433	PF02350	Epimerase_2		UDP-N-acetylglucosamine 2-epimerase	Bashton M, Bateman A	anon	Pfam-B_888 (release 5.2) & Pfam-B_4862 (Release 7.5)	Family	This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc.  Note that some of the enzymes is this family are bifunctional such as Swiss:O35826 and Swiss:Q9Z0P6 in this instance Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of Swiss:O35826 is the kinase domain [3].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.11	0.70	-5.68	187	4483	2012-10-03 16:42:30	2003-04-07 12:59:11	14	13	3029	20	922	3343	2891	333.90	34	89.01	CHANGED	ptlppp..t.....hchpllsTGQHh.pchspphhc............tapl..ps-hp....Ls..pss.tshup.huphlhthpcllpc...pP.DhVl...VhGDssoslAuAlAAhhhpIP.luHlEAG.Rs.........................-hp.s.hPEEhNRphss+luclHFssTppupppLlpEG....h..........ssp.....plassGsssl...Dsl......hhstppltt.........sl..p.............hppphlLlThHRtpshsts..hpplhpslpsls...pp..ph..llashH.sPpspchl.............phlpph.s.......plplhpPLsahcalpLhppuphl............loDSG.GlpcEAss..ls.....hPslsl..R..sER.EuhttGs...shl.l.u..s.pppIlpulpphlts.....tthpthsp....PYG.-GpA.uc+Ilchlt	...............................................................t..htpp..th-thlssTuQH..ccMh-p...lhp............hFpI....p......sD.hs.Ls.......pss..psLs.ch.......Tup....hlttlc.pllpc............cP.DhVL...VaGDTs..oohAsuLAAh.h.............ppIP..VuHlE...AGLRoh........................-hh..s.h...PEEhNRplsspluc...laFu...PTcpu+.pNLlp.E.uh.....................spp..........pIalT.GN.ss.l.DuL..............hhs.h.pp..h.....tt.....................plhtp.....................tsc+hlL.l..T...s....HRc..E.....N.h..s..p.s.....hc.p...lhpA.l.p.pls...pp....cht..llaPhH.....sP.p.s.pch.l.............pc.h.ltph..p.......plpLl-.P.l..sa.h.c.Fh...tLh.....p..cu.h.hl.............l...T.DS.....G..G..l.Q.E.EA..Ps..LG.....pPsLll.........R....s.s..TE.RPE....u......l...p...s..G.T......stL......lG....sc....tppIh.ptsppLlpc...........ppth.pp.hsp..stNPY...G..D.G..p.A.upRIlchl.........................................................................................................	0	306	604	780
+2434	PF00758	EPO_TPO		Erythropoietin/thrombopoietin	Bateman A	anon	Pfam-B_990 (release 2.1)	Domain	\N	25.00	25.00	25.90	25.90	23.50	19.90	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.96	0.71	-4.61	6	114	2012-10-02 01:28:15	2003-04-07 12:59:11	13	1	54	9	46	138	0	150.00	39	69.31	CHANGED	sRLICDSRVLERYlLEA+EAENsTMGCuEussLuENITVPDTKVNFatWK+.EspppAlEVWQGLALLSEAlLpuQAlLANSSQssEsLQLHsDKAlSGLRSLToLLRsLGsQpEthSsP-sss..sAPLRslssDslsKLFRVYuNFLRGKLpLYTGEsCRRGDR	.....t.lCDsRVLp+alhEA+-AEsthhsCsEsssLspslsVPsTclsahtWKphphp...ppA.EVhpGLsLLtEAlhtupu.LusostssthhQLHsD.pu...lpsLtSLpuLL+sLss..ptt...hos.....scs.....ss..hhshp.phhhsshpcLhplhsshLpuKhtL.sst..sspptt.................................	0	2	4	11
+2435	PF00275	EPSP_synthase	EPSP_syntase; 	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	Finn RD	anon	Prosite	Family	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.42	0.70	-6.05	23	10932	2012-10-02 15:27:11	2003-04-07 12:59:11	15	37	4830	176	2360	7857	8210	390.10	27	90.26	CHANGED	lpsssplsGpV.plPGsKShosRslllAALusu.....oplpNlLcucDspphlpsL+pLG..hhphppppsshhspG.htphpss....t.hslhhGNuGTshR.Lsuhhuh.ts........lsLsG-splppRPlspllcuL+phGAcIphppstshsPltlps...hphtslclpssluSthlTuhLhhAshhAcu..sshlps..hsscPplshThphlpphGsplcs.sstp...hhlcGspp...hsu.pahV.uDtSuAuaFlsAAAlssG.pVtlpslshsslp.u...hlt.hLcchG....upls.......hs-stslshtt.........hcshsl..slpshsD.uhslAhhAtFAp.......usoplcshtplRhKEo-RlhuhusELp+lGucscEt............DGh.......psshh.....LpsuclpoatDHRhAMuhuLsu..sps.........tshIccspshs+oaPsah-pL	......................................................................h..s.p.LpGpl..plsG.tp.ushsll.h.A.u.L..h..s.sp....spl.p.s.l...p..h........pDlt.shhph..lp...tLG..............s........p..l....................t...................................t..............s..............s...........s........h.............h.....h........s...........s...s..........t..........h.......t.....s.........h.p............ss...........ph.............s...h...p....h...tsS...hhshts.Lhuthut..s........................plsl.sG...ss.s........l.u.....p....RP.........lchh..lcuL.c.t.h..G.A.p..l.......p........h......p......p......s.........h...........h.ss.hp...........................tpL.p..usc........lh.h...s...h.....s...S........st..sTtslh.h...Au..hh..AcG..............pT.hlp.....s.....hspcPp..l.sc.htphLpp.hG....u..c....l.........p.....s.................s...s..sp.......................lp.l..........p....G......spp.............Lt.u.......t.p...a..pV.s..Dt.p....Auha..l..s.A...........A.........Al........s....s.............G...c..............lhl....p.s.s.......hh.......p.......php............hlh.hLcch.G............splp.......................h.t.c.........s..h..lt.hptt....................hc.h.t..s.l.......sl.p...s.....hs...cs.uhsh..shtu.hst................................hh.shhc.Gsu..lp.p.h.-.phhh.hss..ELp..+h..G.A.c..l.p...ps.................cs.hh...................................................hh.sst....................L..p..G.A..p.V....t..u.h..DhRhuhuh.slAuL...hu.p.G...........s.plpch.tpls+uYsshhccL............................................................................................................................................	1	809	1563	2026
+2436	PF03736	EPTP		EPTP domain	Staub E, Mistry J	anon	Staub E	Repeat	Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section.  The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold [2].	20.60	20.60	20.80	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.87	0.72	-4.21	71	1712	2009-01-15 18:05:59	2003-04-07 12:59:11	12	64	48	0	784	1271	21	45.40	22	22.68	CHANGED	ppFhphQsls....psshshcshsl.sschalllup.hu..top......lhcWss	............pFhpaQsls....hpsshshchapl..s......s......c.............alslus.hs.......top.............lacWs........................	0	61	129	324
+2437	PF01133	ER		Enhancer of rudimentary	Finn RD, Bateman A	anon	Prosite	Family	Enhancer of rudimentary is a protein of unknown function that is highly conserved in plants and animals. This protein is found to be an enhancer of the rudimentary gene Swiss:P05990.	25.00	25.00	25.70	34.10	20.90	24.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.11	0.72	-4.32	13	234	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	144	7	154	192	0	97.70	53	65.02	CHANGED	MSHTILLlQso.p+h-oRTasDYESlspshEGlC+lYE-+LKchNPssssITYDISQLFcFIDsLADLSsLVacpsTtoYhPasKpWIKp+lYthL+ppAt..p	.................oHTILLlQPs.p+.-sRTYsDYESVs-CME.GVCKhYEE+LK+..h.....N...P......sssoITYDISQLF-FIDsLsDLSCLVYctsTp............o.YtPaNK-WIKEKIYhlL++pAt..s...................	0	44	65	117
+2438	PF00810	ER_lumen_recept		ER lumen protein retaining receptor	Bateman A	anon	Pfam-B_1387 (release 2.1)	Family	\N	21.50	21.50	21.50	21.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.90	0.71	-3.71	61	726	2012-10-03 12:15:12	2003-04-07 12:59:11	13	9	338	0	498	703	22	138.40	43	59.98	CHANGED	SCsGlSh......KoQhLYslVFssRYlDL..ap.sah...ShYN......slhK.....lhalsoohhslYlh..hhpa+t...TY-cph..DoFplp.aLlssshl...........................................LAllhs.....ppa......phh-lhWoFSlaLEuVAILPQLhhlp.+o.scsEslTu+YlhsLGhYRsLYlhNWIaRY	...........................SssG.lShKoQ.LaulVa.......s.s.RY.LDL...ap.sah..........ShYNo..hhK..................lhalssohh.slYhh...hhca+s.....TYDtsp.....DoF+.........l.........t.a.........LllPshl...........................................L.uhlhs.........pca..........................shhEl..lWoFSlaLEuVAILPQLhhlp..+T..u........c....sEslTuHYl.FsLGhYRsLYlhNWlaR......................................	0	174	285	401
+2439	PF02732	ERCC4		ERCC4 domain	LOAD	anon	LOAD	Domain	This domain is a family of nucleases. The family includes EME1 which is an essential component of a Holliday junction resolvase [2-3].  EME1 interacts with MUS81 to form a DNA structure-specific endonuclease.	20.70	20.70	20.80	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-11.07	0.71	-4.43	159	1301	2012-10-11 20:44:43	2003-04-07 12:59:11	10	39	620	18	812	1250	227	143.70	22	21.21	CHANGED	lDsRE..hp.st............l.phlpphu..h.phphpsLt..........lGDalh.......ts.......................................phhlERKs.hs..Dhss.....Slh...c..sR..hhpQh......pcLp..p............thpp....s.hlllEsptthhtt.....................hp.............pss.........................sl.....................psslsplplp.h.sltlhhops.hp-ouphltph	............................................................................lD.RE...hp.st..............l.phlpphs......l..phthp.p.L.s..............l.GDalh......ss.................................................................................................phhVERKs.ls.......DLhs.................Slp.........s......uR.hhpQh....................tclp....p.................thpp....................s.hlllE...tpt.st.h.p..............................................................p...................................................sl.......pssLsplplth..thtlhhops.pposphlh...........................................................................................................	1	273	458	660
+2440	PF04404	ERF		ERF superfamily	Aravind L	anon	Aravind L	Family	The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to ERF [1].	25.00	25.00	25.00	25.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.21	0.71	-4.70	43	704	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	504	0	89	596	339	157.60	21	65.36	CHANGED	hhpshsplpppl.t.pKs......sphhph.....pYt..shc-I....lcsl+sllscpGl.hh.hsp.............................spthlplpshlhc.tsu.t-phps.h.tp.......s.sKs....ssQssGouloYA+RYsLsuhFuIsscpDcDs.....................ttptppppsppppssppppp..ttchhpppsp	......................................tthtplptp.l..s..t...pKs...............sph.hpY................pYt..sh..psI....lcslcsll..p..pps..Lhls.pt.sh............................tthhhplpss..hhs...ssG....pphss.hhsp.....................ptsKs....sssQss.GuuhoYu+RYsLsuhhs.Iss.-..c...DsDs....................ttpptpp.tspp.t.p........................................................................................................	0	29	53	69
+2441	PF03463	eRF1_1		eRF1 domain 1	Bateman A	anon	Bateman A	Domain	The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.	21.20	21.20	21.30	22.40	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.36	0.71	-4.58	119	1096	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	518	26	713	1080	196	131.10	28	32.75	CHANGED	h...hppshc.hchcthlchl.cppschhpLhsLlhssDp.hupsh+pl.pc...sssh.....puppsp.....................ppV.sslshtlp+lca....sstsuh....................................lhhsGtlhpt.....sphsphcolslEss..cslslh+.........phDshhhpchhcsh.p	.........................................................pcslc..hch.ct.hlphl.psp.s.....sh..hphhsLlhPscp.h..up..sh+hl.pc................ssshpucssp...............ppVhs.slo.shp+l.ch..............sP.suh........................................................lhhs......Gpll.....sc..............c..s+.tp..hhol-hE..P.....+...s..lshph..................hhhDsthh.schhpth............................................	1	236	416	593
+2442	PF03464	eRF1_2		eRF1 domain 2	Bateman A	anon	Bateman A	Domain	The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.	24.10	24.10	24.10	24.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.50	0.71	-3.83	35	1105	2012-10-02 16:33:16	2003-04-07 12:59:11	10	12	531	23	724	1082	171	129.50	31	32.44	CHANGED	phuhlllDcstAplullpupshcllpchssslPtK+ttGuQSth+at..htcttcpah+cVuEtsspthh.......ppsplculllAGPGhhKsphhppthhctchtp........thlh.llDlShuuctGlpEslcp..uschLsc	............................huhllh-t.stAhhuh.l..pu..s......s.pcllp+hss.slP+K+t..pGG...pSsh+at.......htcthcpahcclu-thsph.h..................shsslpullLAGsu.hKs-hh..pt......hhctchps...........................phlh.lVcsSh..Gscp.Ghppslch..sschLp................................................	0	236	422	602
+2443	PF03465	eRF1_3		eRF1 domain 3	Bateman A	anon	Bateman A	Domain	The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.	21.20	21.20	21.20	22.20	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.31	0.71	-3.81	34	1128	2012-10-10 14:40:03	2003-04-07 12:59:11	10	12	530	29	741	1099	188	117.00	33	29.44	CHANGED	hhpEpcllscFhcplup..DsshssYGhc-lhcAlEhGAl-sLLlh-sLhppc.h..+p............................................h-pLscpscphGuplhllSscpppGpQl.cuFGGIuulLRapl	..................................hpEp+llscaacclsp..Dsu.+ssYG..............hc-sh+AlEh..GAV-....s....Lllh-sL.psc.h.h+pp.............................................................................h-hLsc.......p.h+ph.G.u.plcll....osc..pppGpQh.cuhGGIuulLRYtl...................................	0	245	432	616
+2444	PF03734	YkuD	ErfK_YbiS_YhnG; 	L,D-transpeptidase catalytic domain	Bateman A	anon	COG1376	Domain	This family of proteins are found in a range of bacteria. It has been shown that this domain can act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking [1].  This gives bacteria resistance to beta-lactam antibiotics that inhibit PBPs which usually carry out the cross-linking reaction.  The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.  Several members of this family contain peptidoglycan binding domains.  The molecular structure of YkuD protein shows this domain has a novel tertiary fold consisting of a beta-sandwich with two mixed sheets, one containing five strands and the other, six strands. The two beta-sheets form a cradle capped by an alpha-helix. This family was formerly called the ErfK/YbiS/YcfS/YnhG family, but is now named after the first protein of known structure.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.41	0.71	-3.93	173	11311	2012-10-02 23:30:06	2003-04-07 12:59:11	9	81	3160	8	2612	8151	1995	140.70	20	42.83	CHANGED	pthlhls.....hsp.......phhhh..hc.ssp....hh.hp..h...........lssG......................p....ttTPhGtaplt............h..t....h..............tt...................................................................h.h.ttts....lhlH..ss......................................t.t..SpGClpl.t.............................pcspplhsh................lt.....................................hu.s..............................Vhl	...........................................................................................s..hlhls....hsp........ph.hhh....hp...ssp.................hl..hs..hs...........lu..hG...............................p.sptT...P...p.G.s....h.p.lp.............................p+t.h.sP.s........p...s..s...h...h..h..t..............h.........h..........................................................................hh.h.t.h.h.s.s.s.s......hhlHs..sss.s...h.................................ps.....SpGClRl..p..s............................pchp.t.L.ash................l..................G.s...........V....................................................................................................................................	0	765	1615	2089
+2445	PF03694	Erg28	UPF0143; 	Erg28 like protein	Bateman A, Kerrison ND	anon	SWISS-PROT	Family	This is a family of integral membrane proteins, which may contain four  transmembrane helices.  Members of this family are thought to be involved  in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p  (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the  endoplasmic reticulum or may facilitate interaction between these proteins [1].  The family contains a conserved arginine and histidine that may be  functionally important.	22.20	22.20	24.60	27.20	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.45	0.72	-4.06	21	246	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	215	0	172	225	0	113.00	34	77.67	CHANGED	hGhLshWLlhlSlluhhNolQsYhs..hphoc+lYs...............................scs....sps.osLpuRsFGsWThloullRhauAapl.pspslYpLshhoaslAhsHFhoEhLlF+TspLstshh.....uPLlVuos	.................................shLstWLlhVSlluhhNohQsahs..hthsc+lYs.........................................sps...........sts..ssLpuRTFGsWTlloullRhhsAhpl.pspslYplshhoahlALsHFhoEhlla+T.s.phs...hshh.....uPlhVuo.h.....................	0	46	89	137
+2446	PF04622	ERG2_Sigma1R		ERG2 and Sigma1 receptor like protein	Kerrison ND	anon	DOMO:DM04578;	Family	This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyses a  reaction in ergosterol biosynthesis, which results in unsaturation at C-7  in the B ring of sterols [1]. Sigma 1 receptor is a low molecular mass mammalian protein located in the  endoplasmic reticulum [2], which interacts with endogenous steroid  hormones, such as progesterone and testosterone [3].  It also binds the  sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine [2].   Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA  receptor function, the alpha-adrenergic system and opioid analgesia.	19.50	19.50	20.00	19.80	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.32	0.70	-5.08	7	288	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	227	0	183	275	0	190.10	36	84.41	CHANGED	thhtalslhlslluslh.slpphlhpo.YhFD.cplpcluppulu.as.....sscsllpclhDpLpsh.ss.hhh......ssppEWVFNNAGGAMGsMaIlHASloEYLIhFGTslGTEGHoGhHhADDYFsILpGpQhAassGsh-..uEVYssGssH+htpGps+QYpMP..tssaALEhApGWIPsML.FGhhDsLSSTlDh.TLahTshlTuR-MltsLhhsKF	...........................................................h.......hhhshh....l..h.....hl.......hh....p.....alFs.ppltpluppsh.u.........................stpthhpplhsc.Lpp.p.ass..hl.........................tpptpWlF.......sNA.....GG.h.M.GuMhlLHASloEYlllFGTulGTcG.HoGh.a.h....A-sahs.ILpGp.....ht..ah..sG..s..hc...sElahP.GsshhhtpGpspthphs..sssahlEYuRGh..IPshL.FuhsDoh.SThDh.TLahThhhhu+thhhpLh..h............................................	0	58	101	148
+2447	PF01222	ERG4_ERG24		Ergosterol biosynthesis ERG4/ERG24 family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.58	0.70	-5.94	5	987	2012-10-01 22:51:20	2003-04-07 12:59:11	12	14	331	0	568	1273	263	356.30	30	87.33	CHANGED	+ptcaEFGG.stGAlGIphGhP....lhplahsspucsstsphhhPcohslssLhstI+s.sphlass...h....s+plWTVFhhaaslQAVhYlhLPG+hscGlPLS..sGc+LsY+lNAhao...hllTlAllslLpssplFcLpalhDpFuplhosAIlFuFALoIaLYltSLhssch.hs......c.LAsGGsSGNlIYDFFhG+ELNPRlG......LDlKMFhElRPGhlsWllINLusll+QYcpYGpVoPuLlhVsls..QhLYlsDulhsEEuVLTTMDITaDGFGFMLuFGDluhVPFTYSpQThYLssH.PspluWss.hsluIhllLhsGYYIF+oANuQKNsFR...........T.PtpPpLph..LKaIpTusGopLLsoGWWuhARHINYhGDWlQSLuWuLsTGFs................................olLPYFYslYFhlLLlHRstRD-+KCK+KYGcDWEEYC++VPY.+IIPYla	.......................................................................................................................................................................................................................................................................php...s..h....h...hhh..hahhh...phh..h..h........h........h......l......P...........Gh...h...spGh.L..........sGp.pL.pYphN...u.h.u.............hhh.s...h...s...h......h.s................h..h....h...h...h.t.......h.h...........h.shlh-.pahtlhsss....hlhuh.h....luhhhYh..p.uhhh.t................................tt.oG..s.hl.YDaah.GtELNPR.l.s............hDhK...hF...h.....p....hR..u..h.h.hhh.l........l.....s......l.................uh..........hhc..p...........h...c..................h.....G............h..l...........o...............s.......s...h.................h.hh.hh...................phhY.lh.s.hhh.Ep...................hhlsoh.................D.lhh-taGFhLhahshshlPahYshpshYLs..............p......P....p....h.s.h......................................hhh.l........h.h.h.h.h..h.u.a.hla.c.s.uN.pQKsh...FR.........................t.P..p.....s..h..h..hh.........ph...h....t...o........t........p......G......s....p......LLs...s...GWW.......GhsR+.p.Y.hu..Dh.h......h..u...h.s......a.s.L..s.s...G...h..s............................................................................p....h...s..a...F.Y.......l..a...h...sh.l.L....h...H...R..t..h..R...D.p.t.+.C.t.pK.YG.p..s..WpcYpphV.a.hhlPhla.............................	0	174	294	458
+2448	PF00769	ERM		Ezrin/radixin/moesin family	Bateman A	anon	Pfam-B_851 (release 2.1)	Family	This family of proteins contain a band 4.1 domain (Pfam:PF00373), at their amino terminus.  This family represents the rest of these proteins.	30.00	30.00	30.00	30.00	29.80	29.70	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.00	0.70	-4.84	10	499	2009-09-10 21:10:39	2003-04-07 12:59:11	14	15	129	5	242	462	0	216.90	35	42.32	CHANGED	EchE+cppELcc+hpphEEchpcupccLpcppc+stcL-pctpptccptcpLcpcppchpctpc+LccpstsptcE+ccLttElsEhstclpplcpupp++EpEsschpp-lppupEcc-cs+pchhthhsss.....................s....l.ts.....................sssptct.ss-sst-tSp-L-......s-sphccps...EEcRlTtscKNE+lQcpLpsL+oELussRDEoK.coshDhlHpEN.lRtGcDKYKTLRpIRpGNTKpRVDpFEuM	....................................................................................................EphE+p+pEL.cRLhphcEpsp.pA.pc.tL...tcppcpA..Ltpctphsp-.EA..c...h...........Ltp.ct.....tpA..cpthpclpppuhcp...tcppcp.LttcltEh....p.tpl..ttlp-tpc+....+ccEsp......ph.p.p....chppAp-s.c+s+pcLhthhsts.......................................................s.s............l.ts.........................................st.p..p...........s.....-....s...t....t...t...h....St-hp...............................s-s...hpchs......Ec-Rls.h-Ks.c.+lpc.QL............ptLpoEltth+.cp+...cTt.DhlHsEN...h+.t.G.c..sKYpTL..+........p........l+pGsTKpRls.FEth................................................................................................................	0	56	75	146
+2449	PF04137	ERO1		Endoplasmic Reticulum Oxidoreductin 1 (ERO1)	Wood V, Finn RD	anon	Pfam-B_4729 (release 7.3);	Family	Members of this family are required for the formation of disulphide bonds in the ER [1,2].	21.60	21.60	36.10	24.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.55	0.70	-5.44	39	459	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	292	6	304	440	6	345.10	38	75.19	CHANGED	pplhshLppLsp.scaF+aaKVNLh.ppC.............PFWscs..shC.ss..ps.....................CsVpssscp-.lPt.............sa+h....phps.......ppspp..tt...............hppslss.......tt.pthtthc-...hsp..as..h-Dpss...pusYVDLltNPERaTGYsGts.utplWpuIYcENCF........................spss.p.................................................................s.......ClE++lFYRLISGlHuSIusHLstcY........l......ppcs............................WtsN................lphFhpRl......u.......paP-RlpNLYFsYtlllRAlsKlpsah...pph..ph....ou...sp..........tpDpcs.......+phlpsllsplps....hsth...FDE.....shhFpss..tuhpLKc-F+p+F+N.lSclMDCVsC-KCRLWGKLQTpGhGTALKILFp.ss..........ppt........hp...LpRsElVALlNshsRlSpSlptlc	.........................................................h.tlhPhlppLhp.psaF+aa+....l.sLh..+.C.............PF..W....s-p.....uhC.s...ps................................................CuV....p.ssppc.lP.................................................sh+h....sphpt..........tppspp.....tt.............................lppslsp..........tt.hthtthD-...tpp..aC....-Dpps...spspYVsLlhNPERaT.GYpGss.AhplWpu..IYcENC.F..............p.ts...................................................................ts.C..lEKRsFY+LISGLHuSIshHLstcY..............L.pps......................p..........WssN................lp.FhpRh......s......ptPcR.lpNLYFh.Yhl.LRAlsKhts..ah......pp.......ph..h.oG..s.s.................tpDtcs........+phlhp.llpphps....................hs.h...FDE..............sthF..tss...................pu.pLK.c-.F+t+F.+N....lS+IMDCVGC-.KCRLWGKLQ.stGhGTALKILFp.ct...................................pp.........hpLpRpElVALhNs...hs.RlSpSlptl..............................	0	109	169	247
+2450	PF03238	ESAG1		ESAG protein	Bateman A	anon	Pfam-B_3037 (release 6.5)	Family	Expression-site-associated gene (ESAG) proteins are thought  to be involved in VSG activation. This family includes ESAG 117A Swiss:P04477 as well as ESAG IM Swiss: Q26705.	20.20	20.20	20.20	23.00	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.47	0.70	-5.06	10	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	8	0	13	53	1	220.90	55	71.32	CHANGED	sM-scpcKLEKLISYGNpMGDLVAKsGGLFAEVNESVRAVRKEIPuALIKsNKYYTAIAEITRTVWDDVKAlth..s.ucscCp-QcFcGVtEhcspCGDpTCPLucs.VsEuALpKYKsGCLplsVhsGSVScChNLPRsNLY+SGAlsoSs-sLcW+-cp.t.uphFQLpL+VcsIFGPLIAsFAAGQPPSsLhEMMsNITSLpSRFNEVHuNFTSLLlssNlssNVssTcSTI	.....MctpcDKLEKLI.SaGNpMGDLVAKsGGLFAEVNESVRuVRKElPsALI+sNKYYTAIAEIsRTVWDDVcult....s..sctcCpspchcuVtEhcspCGspTCPLtcu.VsEuuL.pKYKsGCLplsV...s..Gp.Vsc.ChNLPRssLY+sGAVpsSscsLcWcpst...sthFpLpl+VppIFuPLIusFuuGpsPSsLh-MhsNITSL.S+FNEVHsNFTSLLlssslpssVssTsSTI...............	1	0	13	13
+2451	PF03433	EspA	ESPA; 	EspA-like secreted protein 	Finn RD	anon	Pfam-B_4100 (release 6.6)	Family	EspA is the prototypical member of this family. EspA, together with EspB, EspD and Tir are exported by a type III secretion system.  These proteins are essential for attaching and effacing lesion formation. EspA is a structural protein and a major component of a large, transiently expressed, filamentous surface organelle which forms a direct link between the bacterium and the host cell [1,2].	22.20	22.20	22.80	45.30	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.20	0.71	-4.86	7	296	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	247	1	18	151	0	172.00	48	96.44	CHANGED	hS....ssshtuusp.sssssSpshsss.hups-slp....husuhusLh.hhhhh...o-LupuKaspMpppuccu+suQcMANplDthIAclpcss-K.tp.cLPp-VlcYhpD..NGIpV....DGhp.hs....................................................................................ttLspG-LpsVKuAL-spuNpsoDhVsQuQLplQph.pohNsssohhsuhQoh.uch.pu	......................................................................pss..hs...ss..hutp-slp..N.hu.h.usLLhhhhhh...pslu.sKF.......h-hpcsuccupssQchuN.hDthIAcstpus..s.K.....sKtclPpDVIcYhpD..NsIhl....sGho..s.......................................................................................................GcLstGsLQsVKAAlsscANp.TslhspuQlpIQpMSppLNhlhothosl.Sh.hch.S.h....................	0	6	8	13
+2452	PF04806	EspF		EspF protein repeat	Mifsud W	anon	Pfam-B_3518 (release 7.6)	Repeat	The enteropathogenic Escherichia coli EspF secreted protein induces host cell apoptosis. Its proline-rich structure suggests that it may act by binding to SH3 domains or EVH1 domains of host cell signalling proteins [1]. 	20.20	20.20	21.30	20.20	17.50	20.10	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.40	0.72	-3.77	3	690	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	113	3	0	484	0	43.70	74	73.26	CHANGED	IQPARSMAEHIPPAPNWPAPoPPVQNEQSRPLPDVAQRLVQHLAEHG	..............IQPARsMAEHIPPAPNWPAPsPPV..Q...NE...QSRPLPDVAQRLhQHLAEHG.........	0	0	0	0
+2453	PF00756	Esterase		Putative esterase	Bateman A	anon	Pfam-B_476 (release 2.1) & Pfam-B_4968 (Release 7.5)	Family	This family contains Esterase D Swiss:P10768. However it is not clear if all members of the family have the same function.  This family is related to the Pfam:PF00135 family.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.57	0.70	-4.96	20	9472	2012-10-03 11:45:05	2003-04-07 12:59:11	15	87	3654	69	2036	9626	1891	233.50	17	73.54	CHANGED	Sssh.spchpltlaLP.t......ssspphPllYhLDG.......ssa.pphsstphhpphstctth..sh.lshPhGsps.....t.h...........ssptstsppap..salppELsshlcusasspsps.......pulsGpShGGhuALhhALc..aPcpFspluuhSsh..............................ss.Wu..........tpst..psDshhph.t.ssstsslplhlssGsp-s.ht..ph.sph.........hphhstsppht..hphpthsthsc.a......usHshth..WpspLssthhph	......................................................................................................................h.tpphph..t.lhhPss..............tsspth...Pl.l...a....h.....L....c..G.....................................ssh..........p......p....h....t.....h....t.....t....h....h...p.....p.....h.....t.....t.......p....h...t......h.........h.....h...h....l...s......h............s.......t....s.....s.ps.......................h...................................................h.......t......t..........t......s........h.....s.....t..p....at...........sa..l..t...p...E...L....h....s...h...l...c....p...p...a...s....s..sspt..............psl.s.Gt.ShGG..h..s.A...L.h..h...u.lp......p..P....s....t....F.s.......p...l....s..u..h..S..s.h....................................................................................................................................s..Wh....................................t........h........p.......s.....s..h.............h........................................t.....t...........p....t....h............l......h....l...s..........G.....t.......t.....-.........................................................................................h.....t...t.....t..t.h.............h..t.....h................h.........p.....h..........................................a.tth.......h.............................................................................................................................................................................................................................	0	630	1289	1731
+2454	PF01684	ET		ET module	Hutter H, Bateman A	anon	Hutter H	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 8-10 conserved cysteines that probably form 4-5 disulphide bridges. By inspection of the conservation of cysteines it looks like cysteines 1,2,3,4,9 and 10 are always present and that sometimes the pair 5 and 8 or the pair 6 and 7 are missing. This suggests that cysteines 5/8 and 6/7 make disulphide bridges. 	21.80	21.80	28.50	29.40	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.89	0.72	-3.95	22	150	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	5	0	150	131	0	83.50	33	82.03	CHANGED	CYsGlass.sss...hssuuhphCpG..pCuSloht.shNG..pssolYsCsPsslCpsLslss......sCssl.ss.........louCCCs.sssC.sssss	CYsGlass..sss....hssuuhphCp.G..pCuSloh..shsG...pssolYsCsPsslCpsLslss......sCsslpss.........louCCCs.s-sChsss.s.......	0	42	61	150
+2455	PF00766	ETF_alpha		Electron transfer flavoprotein FAD-binding domain	Bateman A	anon	Pfam-B_853 (release 2.1) & Pfam-B_1321 (release 3.0)	Domain	This domain found at the C-terminus of electron transfer flavoprotein alpha chain and binds to FAD [1]. The fold consists of a five-stranded parallel beta sheet as the core of the domain, flanked by alternating helices.  A small part of this domain is donated by the beta chain [1].	21.00	21.00	22.40	23.80	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-9.80	0.72	-4.36	39	4727	2012-10-03 09:55:27	2003-04-07 12:59:11	14	26	2782	14	1280	3485	2076	85.60	48	26.01	CHANGED	ps-.lspAcllVuGGRGltu..tEsFc..llp-LAchL.GusVGuSRssV-..........sGWhss-+QVGQTGKoV+PcLYIAsGISGAIQHhuGMcsSc	.............................p.s-LspAclVVSG..G.RGluu..........t-s.ap...llcpLActL......G.A..s.l......GuSRssV.D..........sGa.hsp-.hQVGQ.T...G+h.V.s.PcLYlAlGISGAIQHlAGhpsSc..................	0	448	834	1086
+2456	PF01012	ETF	ETF_beta; 	Electron transfer flavoprotein domain	Bateman A	anon	Pfam-B_1321 (release 3.0)	Domain	This family includes the homologous domain shared between the alpha and beta subunits of the electron transfer flavoprotein [1].	24.20	24.20	24.40	24.40	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.97	0.71	-4.53	174	9173	2012-10-02 18:00:56	2003-04-07 12:59:11	16	30	2828	46	2509	6583	4289	156.00	22	53.86	CHANGED	sshlls-.p..s......ssplp.shshpslstAtplupt..........p..lssls.......hG.....s.spsspt.....hhs.hGsccllhlsssthsth...sstshutslsphlpp..........ss..lllhussshucs....lusplAstLshshlosss..tlph..pss.................hh..hpRshh...uGp.thsplphs.....tllTlcs..sshps	..........................................s.........t....phtls..hsh.pslptAh.pLtpt.............................p..ls.sl.s................hG.....s..tps......t.p..s.........shs......h............Gs-cslll..p......s..s..t..h.t.th...........s..shApslsshlcp.......................tt..hs....lllhG...ssuhscs................lustl.AthLs.....h..s..hssso....plph....s.s.sp..................................hs.hpRtl...uGh..thh..p..l...phs......sllTlp.sh.p...................................................	0	863	1630	2135
+2457	PF05187	ETF_QO	ETFD; 	Electron transfer flavoprotein-ubiquinone oxidoreductase	Wood V, Bateman A	anon	Pfam-B_2305 (release 7.7)	Family	Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4Fe4S] cluster, are present in a 64-kDa monomer [1]. 	20.40	20.40	20.40	20.40	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.44	0.72	-4.06	73	1342	2012-10-03 08:56:42	2003-04-07 12:59:11	8	18	1195	4	515	1183	1543	109.60	47	19.70	CHANGED	GhhhGhshuul-p...lhp....Gps..PW.TL+.cppsDassLcsAscsp..IsYPKPD....GtLoFD+LSSValSsTNHEE-QPsHLpLc....DsslslshNLshYsuPppRYCPAGVYEhVcc-	................................................GhhhGhhhsGl-p......lht....Gph.Pa....T.....L+.c.p..........c..s............DttsLcs.As..p...s...p........I.....sY......P.K..P.......D....G.pLoFD+.LSSValSsTNHEE-QPsHLpLp..............Dss..lPls.h.NLs...hYs..uPppRY.CPAGVYEhVcp.t............................	1	157	287	409
+2458	PF00178	Ets		Ets-domain	Finn RD	anon	Prosite 	Domain	\N	21.50	21.50	21.50	21.50	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-9.92	0.72	-3.84	15	2375	2012-10-04 14:01:12	2003-04-07 12:59:11	17	22	255	41	1162	2070	0	80.40	50	21.09	CHANGED	plpLWQFLLcLLsD..psppchIpWss.csGEFKls..DP-cVARLWGp+KN.KPsMNY-KLSRALRYYYc+sIl+KV..pGcRasY+Fsss	.........................lpLWpFLL-LLpD....ps.stphIpWps.....c...........pGcFK..lh...Ds-c..............V.ARhW....Gt+Ks......+..P.s..M..N.Y.-KLSRAL......R............Y.Y.Yc....+s..Il..pK..l.....p.G...cRhsY+Fs..p.....................	1	249	337	689
+2459	PF03318	ETX_MTX2		Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2	Mifsud W	anon	Pfam-B_3569 (release 6.5)	Family	This family appears to be distantly related to Pfam:PF01117.	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.49	0.70	-4.80	15	164	2012-10-01 20:43:00	2003-04-07 12:59:11	8	8	81	12	52	305	3	208.90	14	66.88	CHANGED	sshsshsshhspshs........................h..t.sphhshsshasussslsNsTsppQphpThSFscshTcTsSsosTpGhp....huspssuphslsh.....ssEsslpho..lo..YNa...ooosTpTsososphhsPSQsVsVPP+spspsshhlt+sshs.sshpLhssl.up....................shho.hshscsshl.shttstssshsphssshs.hsssspl.phpGoGhhc.hstGsphhl+hschshssssutphs	.............................................................................................h...............................................p....shhhtpshhpN.s.ost.p.p.p.h.p..o...paspshs.po....s..ohosppGhp....huhpsshp..hslPh.....hsp..sshphs..hp....ash......spo...po...ps...so.pp.......p.ph.h..ss....sp...s...l..tVPspppspsphh.lpcsp...hp.ssh..p..h........sph.............................................................................................................................................................................t...................................................................................................	0	27	34	46
+2460	PF01459	Porin_3	Euk_porin; 	Eukaryotic porin	Bateman A	anon	Prodom_3211 (release 99.1) & Pfam-B__3211 (release 7.5)	Family	\N	26.90	26.90	26.90	27.30	26.50	26.80	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.59	0.70	-5.10	90	1317	2009-01-15 18:05:59	2003-04-07 12:59:11	17	7	369	3	757	1211	9	250.60	22	88.76	CHANGED	sPssap-luKcs.+Dlhs+s.a.hssh+hclssh..ssu.stFpsou.............stshtss.......................hsstslpspat.......shshs................................................................hphss.ssslssplplpcthstu..l+sphssphsssp......psupl..chpYppsphshssslsh..t......sshhsushlhuhs.slslGs-ssacsspsphsp.shuluas.sp..................................cahsuhpl.sp......ssshsuSaap+ls..splpsGs-hshshsss.................pssho..........lGspYplcpss..tl+u+lsssGhlushhpccL..psslplsluuplDsh+t........stKlG	.......................................................................................Pssap-ls+ps..+..Dlhsps....a....h.s..hh....+hslpp.....s.u..s.tFp.sst........................shphtst..........................................................hssh..slpspat................shshh.......................................................................................................................................................phss...s...sshssp..h.pl.p.pt.l.spu...L+.hph..ss....p...h......s...s.s.p..............................psspl.......chpYpt.pphshs.ssls...h...................ssh.hh..ss...hlh.u..hp...s..........hhhG.hphsa.cttp.sp..hsp........shs...luat..s....t....................................ca.hsh.pl.pp..............tsth.tuSh.a..p.....+.ls......pplpsuschsh..s.h.tsp.................p.s.p.hs...lu..spap..lctss..hh+....u..plsssuhluhhhpppl....t.s.l.pl..slu..u.lDthp...........shKhG....................................................................................	0	215	374	573
+2461	PF04346	EutH		Ethanolamine utilisation protein, EutH	Mifsud W	anon	COG3192	Family	EutH is a bacterial membrane protein whose molecular function is unknown. It has been suggested that it may act as an ethanolamine transporter, responsible for carrying ethanolamine from the periplasm to the cytoplasm [1].	25.00	25.00	28.10	28.10	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-11.99	0.70	-5.49	27	734	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	686	0	58	324	5	371.20	64	95.93	CHANGED	M..s.INcIIlYIhhlFhVlGAlDpl..................lGs+h.GLGccF-EGlhuMGsLAluMsGIhulAPlLuplLpsllsPlaphlGADPuhFAsTlLAsDMGGY.LAppLAp......s.cuhlauGlIlGuMhGsTIVFoIPVuLGlIcKcD+cYhApGlLsGllTIPlGshluGl.ls..............G......hshhhllpNLlPlllhulLlAlGLhhhPstMI+GFhhFGKhlsslIslGLshullptlTG....hslls............GhsPI...........pculpllGpIuIhLAGAFPhVhllT+hhpKPLttlGchLGhsssuAAGhlAoLANsIsMFthhK-MssRGKllNlAFuVsAAFlhGDHLGFoAuhpsshIhPhllGKLlGGlsAlhlAhhls	..........................Mu.INEIIMYIMMhFMLIuAVD+.I..................hGppl.G.GuQFEEGFMAMGALuLAMVGhsALAPVLA+VLGPVIlPVYEhLGAsPSMFAGTLLAsDMGGFhLAcELAu......DsuAWLaSGLILGSMMGPTIVFSIPVALGIIE.sDR+YLALGVLAGIVTIPIGCIAGGL.lAhhsth............sh..lp......FoFuLILhNhIPVlIVAlLlALGLKFI.PEKMIsGFQIFuKalVALITlGLAAAllcaLLG....acLIP.........GlDPIhhs.....t-.hRAIEVIGSIusVLhGAYPMVh.LLTRaFcKPLMsVGKlLsM.NslAAAGMVATLANNIPMFGMMKp.MDsRGKVINsAFAVSAAFsLGDHLGFsAus.h....s.uM.IFPMIVGKLlGGVTAIuVAhhL.s..................	0	29	41	51
+2462	PF03319	EutN_CcmL		Ethanolamine utilisation protein EutN/carboxysome	Mifsud W	anon	Pfam-B_3053 (release 6.5)	Family	The crystal structure of EutN contains a central five-stranded beta-barrel, with an alpha-helix at the open end of this barrel (PDB:2HD3). The structure also contains three additional beta-strands, which help the formation of a tight hexamer, with a hole in the center. this suggests that EutN forms a pore, with an opening of 26 Angstrom in diameter on one face and 14 Angstrom on the other face [2]. EutN is involved in the cobalamin-dependent degradation of ethanolamine [1].	25.00	25.00	27.80	27.40	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.57	0.72	-3.60	51	1340	2012-10-03 20:18:02	2003-04-07 12:59:11	8	3	931	33	216	583	325	82.50	46	89.31	CHANGED	Mhlu....+VlGslhuTpKsssLsGtKLLlVc.lc...........ptt.tuphhVAsDslGAGhG-hVLlsp.GSuARtshss.p.ssPl...DssIlGIlD	..........MpLAcVsGslVuTp+ppuLsspKLLlVchls...........................p.s.p..ssupstVAlD.slG.AGsGEhVLlss.GSoARpu.hps...p....stPl.....DhsllGIlD...................	0	95	156	191
+2463	PF02472	ExbD		Biopolymer transport protein ExbD/TolR	Mian N, Bateman A	anon	Pfam-B_2343 (release 5.4)	Family	This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria [1]. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various  receptor bound substrates including colicins [2].	25.40	25.40	25.40	25.90	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.75	0.71	-4.15	80	6991	2009-09-11 05:16:59	2003-04-07 12:59:11	11	4	2435	5	1847	4807	3274	131.40	24	90.36	CHANGED	cpp.tsplslsPhlDlhalLLlFFhl.oushsptt....h..plsL.Psssssp................hpppptlhlsls....tc.....sp......hh.......................................lssp...h...shppLtspLpphtpppsp..........................lllpuDpsssappllplhsthpps.Ghpplslssptp	..........................................p....hs-INlsPhlDVhLVLLlhFMl..Tushhsps.................l.....plsL...P.pus..sss.........................spspps.l..h.lsls............ss................sp....................lh............................................................................................................................................................lspp..........l............shpp.l.t.s.t.l..p...p...ht.pt..p.sps........................................................................hlhlp...uDcs.ssYpplhplhstlpp..u.Gh..p.plulhst..t....................................................................................	0	593	1191	1567
+2464	PF01541	GIY-YIG	Exci_endo_N; 	GIY-YIG catalytic domain	Bashton M, Bateman A	anon	Pfam-B_489 (release 4.0)	Domain	This domain called GIY-YIG is found in the amino terminal region of excinuclease abc subunit c (uvrC), bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage.  The structure of I-TevI a GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices [4]. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.17	0.72	-3.61	105	9798	2012-10-01 19:55:08	2003-04-07 12:59:11	19	83	4836	20	2329	7330	3586	77.80	26	19.92	CHANGED	psslYhlh....st......ps...................phh....YlGpo.p..sl.ppRh.ppH..hps.......tptpht.................hpshphh.hlphhpspptt.........hphEpthlpthps.......thN	........................................................................................t.sulYhhp..........st........ss.....................................phl.....YlGpu...p........s...L...+p...Rl..psa.......hps..............p.s..s..p.t.ppt............................hpsh..phh....h.h..p..h...s..s......s....c.scA........................LhhEt.pll+hhps.....................................................................................	0	771	1529	1995
+2465	PF03081	Exo70		Exo70 exocyst complex subunit	Mifsud W	anon	Pfam-B_2462 (release 6.4)	Family	The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae [1], Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast [1]. Exo70 interacts with the Rho3 GTPase [4]. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud) [3]. In humans, the functions of Exo70 and the exocyst complex are less well characterised: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis [2].	23.70	23.70	24.30	23.80	23.30	23.60	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.07	0.70	-5.67	58	882	2012-10-03 17:31:52	2003-04-07 12:59:11	10	11	263	7	540	852	0	323.30	22	57.29	CHANGED	hppWlpshphshpslhtsEc.pLhspl................asst..s.......tppsFscls.ppslt.....pllphsctls...................pstpssp.tlhcll-hhpslpch...hsplpthhps.........t.hh...phpph..........hppLtcsspphht-hhstlpp.................psspphs.ssGulp.lTphlMsalphLs..-apssLspllts.ssss...................................sts.luphlspllssLhssL-t+....u+thp............................c.uL........ptlFLhNNhpalhpp..lcp............S...cLtslLGsphhpchp...pthcpahst...YhcssWspl.hshLps...........................................tths..........spppp.hK-+.............h+pFspuF--hhppQ.ppapl..sDspLRppL+psltphll...PsYppFhs+atstht.....t........al+as.s--..lcshlscL	..................................................................................................h.hh..shthlh.sEh.plhppl................................hst..t..............tttsFsphs..pssh.......tlhp.hscsls.......................hthpsst..plhpll.s.hhpslpph.................hsphpt.hhts......................................................htt...ph.th..................hppltpsst.thh..t...-h.ptlpp.................pstpshs.........s.GslH...lTp.s....hpalphLh..cappslttlh.tp.ttts........................................................................................................spp.luth....lhplltsLtts....L-sK.............u.+.h.Yc............................-.uL................pt.lFLhNNhpalhpp..lcp...............................................................................S......pLttl..l...u..p....p.hh.pphp....phh.cphhpt...Y.cs.Wtpl.hsh..Ltp........................................................t..t.........stpp...p..l.K.c+.................hctFNttF--hhptQ..ptWhl.....sD..pLRppl+.sltphlh...s.sYpt..Fhp+.atth........................t.t+al+.Ys.scplpphltp.....................................	0	109	289	425
+2466	PF04257	Exonuc_V_gamma		Exodeoxyribonuclease V, gamma subunit 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The Exodeoxyribonuclease V enzyme is a multi-subunit enzyme comprised of the proteins RecB, RecC (this family) and  RecD.  This enzyme plays an important role in homologous genetic recombination, repair of double strand DNA breaks resistance to UV irradiation and chemical DNA-damage. The enzyme (EC:3.1.11.5) catalyses ssDNA or dsDNA-dependent ATP hydrolysis, hydrolysis of ssDNA or dsDNA and unwinding of dsDNA [1]. This family consists of two AAA domains.	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	805	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.30	0.70	-13.43	0.70	-6.56	84	2140	2012-10-05 12:31:08	2003-04-07 12:59:11	9	6	1971	4	352	2371	649	635.20	26	61.91	CHANGED	MlplapSN+hEhLsphLsphlp...pPhsp.........Phps...EhllVpS.GhspWLphpLA............pptG..IuAslcF.shPusalhphhppl.lsp..ls...p....ps.s........FsppslsW+lhplL.....Pp......hh.........pp.st.atsLppYL.............sscsst...........h+haQLAp+lADlFDpYhlYR..............P-WlssWcpG.......................tthstspp.W...........QshLWRtL...hpchtttt.t...p..........hh.....hptlpp..tptt.ptLPc.RlhlFGlSsLsshhLclLpuLuph..t-VpLahhNPsppaWu..-lhs..p+phhp...................................t.tppthhttu......sPLLAuhG+.GR-ahphLtph.........................ttpch-hF...........ssppss...............LLpplQs-ILp..................tttptpht..hstsDpSlplHsCHSshREVElL+DpLLphh....spD....s.s......LpP+DIlVMsPDl-sYAPhIpAVF....u.................stptlPasl.uD...pshpppsslhtuhhpLLsL.spoRhsss-llsLLpsPsltp+Fslspp-lpplcpWlppuGlRWGlDtpp+pp...h..ths....s.pppoWphGLcRhLLGaAhs.................sssh..........hp....slhPa.splpG.puphlG+LhphlcpLpphhppL....pps.pshppWtphlppllsshF...sss.....scpphp...lptlpptlsph.tptsppus...............hpp..........lslsllpphLtppLsppsts..tFhsGsloFCslhPMRuIPF+VlCLLGhN-GsaPRpptssu.FDLhsp..p.....+.hGDRu+R--DRYLFLEALLSARcpLYlSYlGp.sh+DssphsPSlllsELl-alppsh..................stpshpph...h......hp.HsLpPFs.phF...................tssthhSas..ppahtstpthpptt.................................................tshhst.....................stst.pslsLpp	.............................................................................................................................................................................................................................................hhlh.upph-.L.thh...ht.......t..............sht....p...l.lV.u.uhtpaLp.tl..u.....................tt...G..lsAslt.h..hstthhhphh.th..h...........t................ps...............h...s..t.h.W.p..lht...ll............................t.........h.................................tp..........h..........lttaL.............................................t.....tt............................thaplutphAslFspY.hhR...............sphl.tWtts........................................h.....tt....W............Qs.LWp.tl...ht.h.t...t.......................................................h.....httl............t.t..thPt..p...lhlhuhsths...lphlttluph....hplhlhh.sPst..hWtsl.t........t.h.t...............................................................t........psL.LsthG+.sp-...hL.t.............................................tha.........................................................t...ts............hLtt..lQtslhp...................................................................................t.ptth...ls.tD.p.S.....lphasC..Hos.RElE.lLp-pLLthl....pps..............s..s........LpP+DllV..hs..sD...lssYsPhIpAlF..................u.....................spthlP..atl.uD...pp.stp..pp...Pl...lpshhsLLsL.......p......uRa.stp-llsLLcs...ss...l.t.t...+F...slsp.p....slphl......cpalptuGI...R........a..Ghsttphtt...................ths........t.ttpoWp.hu..l.....p...R..hlL....Ghuh.t....................tts...............h.t....s....hh.s........h...s.......t......tu.........hth.h.GpLsp.hl.....tLp........hhp...tl...........tp.......t.sh.t...p.W.h......h...h...p...p...h..l..p...thh.........s..............t.pttht..............ht.lpp....h...tth...htt...h.t.st.........................h..tt....................lsh.t.h.l.tp.....l.t..t..t..L......st.t.......thp....t..a.h..sG...lshsohhshRulPa+llslLGhs.-Gs.aP..c..p.................s.......s......h.......D......L....hst...t..................t....G.........D.R.........s.........pR...p...-...-R.hL............hL.-u......l..huApp...Lhlo..Yh.G..t..s..p..ss...p.....h......Pusl...lp...pL..h-.h...ltt.h...................................s..th..........h...Hsh.sFs.p..a.............................s.....sas..tphh.httt..tt............................................................hth......................................................................................................................................................................................................................................................................................	0	96	194	283
+2467	PF02601	Exonuc_VII_L	Exonuclease_VII; 	Exonuclease VII, large subunit	Bashton M, Bateman A	anon	COG1570	Family	This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones [1].	22.30	22.30	22.40	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.94	0.70	-5.24	27	4810	2009-09-16 18:18:13	2003-04-07 12:59:11	10	9	4139	0	1058	3717	1818	268.20	31	69.15	CHANGED	lFchs+KpslPthPp+IullTStouAuhpDhhcshpc..RhshsclhlhsshVQGcsAspplhpAlpph..s....th..hDslllsRGGGShpDLhsFNcpplsRslspss..lPVloGIGHEsDpTlsDhVADhRssTPTtA....Achllsctpcht...ppLpshppclppshppplcpppppLthhppphh..s........................................lpppppplpphtp+ltp......................shpphhpptppplpp...................................................................................................................................................LpppLcshsPpphLpRGaullh.pcG+llpsspcl.cpsctlplpht-Gphtspl	.......................................................................LFs.phKpslP..hscplGllTS..o..GAul..+Dllpslpc....RhP..hp.lllaPshVQGppAs...........t..pIspulphh...............s....t.......h......t.....................p.......hDllIluRGGGSlEDLW.sFN-.EhlsRAlhtsp...hP.llSuVGHE.sDh.TlsDaVADhRAsTPouA.............AEhs.s....s.s.t.t.-hh....pplpphpt+l...tpshpph..lp.ppppplpplppph.htp.....................................................................P.hh.......hpt.p.tp.p.lcph.p.p..c.lpt....................................................................shp.p.hlp...ptppphptht....................................h.......................................................h......................ht..................................................................................................................................................................................t.ttpht.h.ptLpsl.s.P..th....lt..RGY..u...ls.p...................p.....p.s......p....h.lppsppl...p.sptlphphtDG.lps.............................................................................................................................................................	0	371	715	913
+2468	PF02095	Extensin_1	Extensin; 	Extensin-like protein repeat	Mian N, Bateman A	anon	IPR002966	Repeat	\N	15.00	0.20	15.20	0.20	14.60	0.10	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.48	0.74	-5.49	0.74	-3.49	28	430	2009-09-16 13:20:14	2003-04-07 12:59:11	10	19	12	0	56	410	4	9.60	82	76.50	CHANGED	PPVYKPPVEK	.....PPVYKPPVEK....	0	0	56	56
+2469	PF01267	F-actin_cap_A		F-actin capping protein alpha subunit	Finn RD, Bateman A	anon	Prosite	Family	\N	22.30	22.30	37.40	26.90	21.60	20.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.93	0.70	-5.34	39	514	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	296	35	304	465	1	246.50	40	88.89	CHANGED	pptcl..ssphlpsAPPGEls-VhsDl+sl.hss..........t...lpss...ltsAhppYNpcphsslclss..ppsllop.ascl..........tss+YhDspspptFphDHlppcusshps......h....spph-.h.....p..psl.cpLp....tYspcaY.ssushsV.........................................................................................................................................ashpssst........................ltllIhup+asspNFasGcWRSpaphs......t...plpGplclplHYYEDGNVpLpssKshpp......sh...ss...t.ApsllptIpphEspappplscsaspls-ssF.KuLRRpLPlTRsKlsWs+.lssY+LGp-	.....................................hcIsspFlhpAPPGEh...s-Vhs.......Dl+hL.ls.s..........-.sllcps...hs..pAFtpYN.hcQh..sslc.l...pG...ppp........V...lIocascL....................................................usu+ahDPcs.phsFpaDHlcpcAo.Dsps...........hp.....stth-th................R.pulppsLp....sYlp-HY..ssGs...s.s..V.......................................................................................................................................................................................a.spp.csp................................plhssIpuppapspNFWNGRWRSp.Wphsh......ssss....plsGhl+lp.VHYYED.GNVpLsopK-lpp................ols...sss......t..psApphl+hlctsEscYQs....uls-sapshS-ssF.Ku.LRRQLPVTRoKl-WsK.lhuY+lGp-.........................................	0	82	132	212
+2470	PF00469	F-protein		Negative factor, (F-Protein) or Nef	Finn RD	anon	Pfam-B_128 (release 1.0)	Family	Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to  bind specifically to a subset of the Src kinase family.	20.60	15.00	20.70	15.00	20.30	14.90	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.64	0.70	-4.97	20	19129	2009-09-11 11:41:56	2003-04-07 12:59:11	15	3	100	35	0	15393	0	175.30	58	97.39	CHANGED	GuuhSK+pspsh.slRERLh+s.ttssutp.....t....u.st.spttsS.shEtp.thhpucs................hpppNhD...l-up--.-cVG.hPVpPpVPLRsMTYKhAlDhSHFlKEKGGLEGlaYScRRpcILDLYl.+EpGIhPDWQNYTsGPGlRYPhsFGWhaKLVPV-spptsE....-sEspCLlHPuQppthDD..scGElLhW+FDspLAhcacAhphaPEpatc	.................................................................GGKWS.K.p.p.h...h..G.Wss.lRERh+Rs......psu.t...........................G.V.G............AsSRDL.E+.+....GA.l.T.oS.N................Tst.sN.u..-..C...A.W.L...E.......A......Q...E..-....E...E...VG.FPVRPQVPLRPMTYKu..AhDLS.HFLKEKGG.L.EGLla.Sp.+RQ-ILDL.WlY+TQGaFPDWQNYTP..GPGh..........RaPLTF.GWCaKLVP.V.-spclEc...scGEss.sLL.H.Ph......s..H.G.h-D..s..ctEVLhW+FDSpLAh+.H..hA+E.hHPEaap................................	1	0	0	0
+2471	PF03807	F420_oxidored		NADP oxidoreductase coenzyme F420-dependent	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.98	0.72	-3.56	56	6885	2012-10-10 17:06:42	2003-04-07 12:59:11	12	28	4452	62	2074	23061	11556	93.30	25	34.58	CHANGED	plull.GsGshGpulupthstsG.......pplhhusuRss-+httht.pphs............htsps.sst-Asp..tu-lllluV.hpth.plhppl........thhps+lllsssss	..................................................pIuhI...G.s...Gs...M.u....p..A...l...h....p...G..l....l.....p....s..u.................s.ppl.....h......s........s..t......s..........p...p...h........p....t....l...t....p.p.hG......................................h.p..s..s..s...........s...s......t..c.....s......s.p........pu.....D.....l.....l..l.......L...A.......V....K....P..p.....h....h......t...p...l.l...ppl............tth.t...p..s.p....l.llSlsAG....................................................................................................................................	0	639	1255	1704
+2472	PF01115	F_actin_cap_B		F-actin capping protein, beta subunit	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.80	25.50	21.20	22.80	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.57	0.70	-5.17	31	384	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	276	28	239	354	4	220.90	55	84.34	CHANGED	phDuAL..DLlRRLsPpplccNLsslhs.LsP............cLs-DLLSSVDpPL+lpp.sppos..+-YLtCDYNRDGDSYRSPWSNpYaPsls.................-ushPScpLRcLElpANcuFDhYR-LYYEG.Gl........SSVYLWDl-ct......................uFAGVVLlKKs............................................spphsGsWDSIHVhElpppspt...........sspY+LTSTVlLpLps............p..t.....suslsLSGsLTRQtEpshslsss.......ssHlsNlGphlE-hEsphRshLpplYFuKsKDIl	...................hDsALDLhRRLsPpplccNLssLlsL.sP.............sLsEDLLSSVDQPLclt+.DctsG........+DYLLCDYNRDGDSYRSPW.......SNcY-PPL-........................DGshPSt+LRKLElcANpAFD.YR-LY..aEG.GV.............SSVYLWDLDc.......................GFA.GVlLlKKs.........................................s.ss.up.p.pGsWDSIHVhE.lp..-+.up............su.c.YKLTSTVhL.hLpT.....................................sp..pu.....sGphs..LuGslTR.QhE.....pD.slsss...........................................ssHluNlG+hVEDMEsKhRshLp-lYFGKsKDlV..........................	0	89	133	198
+2473	PF01116	F_bP_aldolase		Fructose-bisphosphate aldolase class-II	Finn RD, Bateman A	anon	Prosite	Domain	\N	25.40	25.40	25.70	25.70	25.00	25.20	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.79	0.70	-5.31	188	7516	2012-10-03 05:58:16	2003-04-07 12:59:11	15	14	4376	71	1389	4343	1369	297.90	34	95.98	CHANGED	slsshpclLpcApcstYAlsAFNlsNhEhlpAllcAApctpSPlIlQhSpGsh.pah.................G.hthlsthscshAcph.s.......VP.VsLHLDHups......h-slhpAlct........GF.oSl.......MhDuS.......chs.hEENlphT+cllchA+ths..ls...VEuElGpl..G.....Gp..EDults...ptt...........pthhTsP--AtcFsccTGlDu.....LAsulGssHG..hYps.........pPp........Lshp..h...................................LpcIpptl........................sl.......P.LVLHGu..........SGlsp-.....................plpculphGlsKlNlsT-hphAaspul....................+chltpp.st............aDPRphltsuppuhpchlpcphc..hh.Goss+s	....................................h..sshpphlppApc..psY.Al.s..AFN..s..s..N..h..E..hhp...AllcuApc.h.c.u.P.V.I.l.ph..S.s..Gut..p.ah..................G.ht.h.h...t...p.h..l...psh.u..cp.h..s........lPV.slHhDHu..tp................h-shhpulct..............GF.oSl......MhDuS..................chs.h....-E....Nlphs+c...l....V-h....sHt....hG..........loVEuELGsl........G.......Gp...EDslsspt...............pthh.TsP--s.t.ch.lpcT...GlDu......LAsulGssHG..sYp...............pPp..............Lshp..h...................................Lcclpchl.............................sl....P.LV...lHGu.....................SG..lspc......................c.Ip.c.uI.p.h...G.Vs..KlNlsT-.h.phAhsp.ul...................................+chhtpp...st............................aD.P.Rp.a.l.tsuppAhpphlppt.hp...hGstsp............................................................................................	0	471	906	1182
+2474	PF03405	FA_desaturase_2		Fatty acid desaturase	Bateman A	anon	Bateman A	Family	\N	21.60	21.60	21.60	21.90	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.02	0.70	-5.67	11	926	2012-10-01 21:25:29	2003-04-07 12:59:11	9	3	348	37	263	879	84	289.00	38	89.32	CHANGED	PPcKhEIF+SLEuWAccN.lLshLKPVEKsWQPpDFLPDPsS..DuF...p-QV+ELRcRs+ELPD-YFVVLVGDMITEEALPTYQTMlNsLDGl+DETGAS.oPWAlWTRAWTAEENRHGDLLNKYLYLSGRVDM+pIEKTIQYLIGSGMDPtTENNPYL.......GFlYTSFQERATFISHGNTARLAK-aGDhpLAQICGoIAuDEKRHETAYTKIVEKLFElDPDsTlLAlADMM+KKIoMPAHLMYDGcDssLFcHFSAVAQRlGVYTA+DYsD.ILEaLVsRWcV-KlT.GLSuEGR+AQD....aVCuLssRIRRLEERAptRA+ptt...slPFSWIFsRcV	.............................................................phclhpp.L-..shs-pp.l.pa.Lp.scc.sWpPpDal.P.......spu.............csF........h..tsc-hc.ct...........ppls-shhlshVsshlTE-sLPo....Y....pp.lsp....h.....u.h...........s..G...u...............sWu.tW.sptWTAEENRHG.lLpc.YL.hl.ot.pVD.p.p.lEcsh.hllss...Ghc.s..t.p...p..s.sshh.................uhlYs.oFQEhAThlS.HtN.....Tu.....+h..u.............u.........D.hL.uplhupIAuDEpRHthhYppllcphh-l..sP.stshhAhschhpp.hpMP.u.t.hh.-.................................Fp.+huslhtchGVYssp.pa.h.-.llp.l.lpcWcl.p.ht..s....los-Gp....+Ap....-....alp....tLs...ph...p+h.....pE.ptp.t.hh.t...p......................................................................................................................................................	0	59	187	239
+2475	PF04116	FA_hydroxylase	Fatty_acid_hyrd; 	Fatty acid hydroxylase superfamily	Bateman A, Wood V, Finn RD	anon	Pfam-B_7847 (release 7.3) & DOMO:DM04600 & Pfam-B_905 (release 4.1);	Family	This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases.  Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways [1].  This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif.  Members of this family are integral membrane proteins.	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.55	0.71	-3.68	122	4549	2009-01-15 18:05:59	2003-04-07 12:59:11	8	43	1563	0	2248	4426	2057	115.30	21	37.33	CHANGED	hllhhlhh-hh.hYhhHR.hhH........hth...la...th..HthH.H...ps.......pt.phh....ssht...hps.hphlhhshhhh.................hhh...hh................hhh.hhhhhhhhhhtshhthhsHssh....................hhhh.....hhhthhhhssph..HphH.Ht	...................................................h.hhhhlhh-.hh.hYahHR.hhH......................hsh........la...ph.....H.p...s.H..H........p..........................pt..tsh.........suhh.........hps...hp...hhhh.shhhh........................hhs.....hhh.....................hs..h..t..s...h..s...h..h.hhhhh.hh.hht..hhsHssh................................hhh..............t.h..h.t.h...h...h.....s...s..sph......HchHH.........................................................	0	659	1293	1875
+2476	PF02504	FA_synthesis		Fatty acid synthesis protein	Mian N, Bateman A	anon	Pfam-B_1671 (release 5.4)	Family	The plsX gene is part of the bacterial fab gene cluster which encodes several key fatty acid biosynthetic enzymes [1]. The exact function of the plsX protein in fatty acid synthesis is unknown.	19.90	19.90	20.00	20.00	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.83	0.70	-5.56	11	3673	2012-10-02 21:08:39	2003-04-07 12:59:11	10	5	3469	4	781	2569	2334	315.60	40	93.65	CHANGED	h+lulDsMGGDauPh...pllcGllpAhpshs.lchhLlGsccthpshlpc.....cpsp.lpllpApshlpMc-sPstAlR+Kc.SSMtlulshl+cGcADuhlSAGNTGAlhuluhh+lutlpulsRPAlsshlPThs.G.hsllLDlGANV-scPccLlpFAlMGpsYupplh.shcsP.+lGLLNIGsEEpKGs-.....hh+psachL+sh....shsFlGNlEupDlhsGhsDVlVsDG......FsGNlhLKosEGssphltpll+-chcpshhutLtull...l..slKphtp+hDaspYsGuslhG.lstsVIKsHGsusupulhsAIctAtphlpsslsp+	....................................................................................plAlDsMGGDauPp...shl.ushp......A..lp..........p....h....s....p....l.c.llLhG..s.p....st.....l.....p...h..Lsp............................t....p.....+.....lp.....l.lps.s...-.h.Is.-.-..c..P..s.p.Al..RpK+.sS..S.......M...........hl...........AhchV...........K............c...........G....c....AcAsl..S..A..G..NTGALMuhuhhlltp.l.......c.G.......I.......-........R..P..A..LssslP.....o......h..............p....G....tslhLDlGAN..s-scsppLhQFAlMGuhaAcplh...slp.....pP..RVuLL...N...l...GpE.-sKGs-.....hh+cuhpLL...pp.t..........sl.NFlG.lEup-.lh.s..G....p...s.....D..VlVsDG......FsGNlsLKohEGsu....p.hl....h.p.hL.Kp.p....h....p.....s....u....h....h...u....K......l....u.u.ll........lp.ss.L..p...p...h...t...p.+hD.s.pYs..GAsL.L.G..LcGsVlKoHGuusscAhtsAI.c.pAhphlcppls..t.......................................	0	273	513	659
+2477	PF01557	FAA_hydrolase		Fumarylacetoacetate (FAA) hydrolase family	Bashton M, Bateman A	anon	Pfam-B_641 (release 4.0) & Pfam-B_1228 (release 4.1)	Family	This family consists of fumarylacetoacetate (FAA) hydrolase,  or fumarylacetoacetate hydrolase (FAH) and it also includes  HHDD isomerase/OPET decarboxylase from E. coli strain W.    FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses  fumarylacetoacetate into fumarate and acetoacetate which then join the  citric acid cycle [1]. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to  liver cirrhosis, hepatocellular carcinoma, renal tubular damages and  neurologic crises amongst other symptoms [1]. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites [3]. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED.  The final products of this pathway are pyruvic acid and succinic  semialdehyde. This family also includes various hydratases and 4-oxalocrotonate  decarboxylases which are involved in the bacterial meta-cleavage  pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli Swiss:P77608 is involved in the phenylpropionic acid pathway of E. coli and catalyses the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor [5]. OHED hydratase encoded by hpcG in E. coli Swiss:P42270 is involved  in the homoprotocatechuic acid (HPC) catabolism [6]. XylI in P. putida Swiss:P49155 is a 4-Oxalocrotonate decarboxylase [7].	23.90	23.90	23.90	23.90	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.56	0.70	-4.89	95	10787	2012-10-02 17:33:27	2003-04-07 12:59:11	13	37	3508	112	3559	8643	4023	213.40	24	76.20	CHANGED	p.lhshuhN........at.....p+sppht...........................................hshPh.....tsh....hah+sssulsu.....ss......................s.l..hhPtt.................tt.....lcaE.sELull....lG+..tspph.......ppA..hs.hlhGaslssDlo.s.......................Rch......phtth...........hhh.uKuh-shsslGPh.....lsshsphst....t.............................slplpspl.........................NGch..hpcu..ss.schlasstplluh.lSphh.................sLpsGDl....lhTGTs...t.s.......................................................................tsshhlpsGD...p.lpspl...............tt.........lGslp.s..pls	.................................................................................................lhshuhsat........sHstphs..................................s.t..........tsh........hFh+.s..s.s.....s......l....s..s......st.s............................s..l.....hhPpt....................................stp....hcaE.sELull...................lG+............sspph........s.pcA....hc...tlh..Ga.............s..ls.Dlo...t.........................R....ch..........Q.tptt..............shht..uKuhss.sss.l.G.....Ph.......lhs.hs.p.lss.........p.......................................s.lslphpl...........................................NGch..........hppu.....ss.....ss....h....las......h........s....p....l...l....u....a..l....ophh..................sLpsGDl....IhTGTs.......t..G.............t.................................................hlps.GD......p..lplph..............ps......lGp.lps.h.h...........................................	0	912	2048	2900
+2478	PF00667	FAD_binding_1	FAD_binding; 	FAD binding domain	Bateman A	anon	Pfam-B_180 (release 2.1)	Domain	This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.	21.80	21.80	21.80	21.80	21.40	21.70	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.45	0.70	-4.90	15	3726	2012-10-03 00:38:56	2003-04-07 12:59:11	15	73	2009	39	1475	3268	224	195.00	27	27.25	CHANGED	sPhctppsFhuslhss+cLpsssusRsshHlElDluso....ulpYpsGDHlGVaPsNspphVccllchlslss...cpslpLcsh-tp..........hc.Ph.sPsTlppALpaal-Iss.sPo+phLptLAsaAs-ts-+pcLchLuss...htpcapchthspshollclhccFPSschPhs.hLlsllPpLpPRYYSISSSschpPspVHlTssVVpacs....spG+h+pGVsSsa	..........................................................................................s.....ttsh.Aplhts.p.pl....s....s...........s...........u.....p...+..s.s.h..H.lEl....c...........l....s....ss..............slpYp.....sGD.t.luVhs.........pN.ss.....t.......hVppll...p..h..l..t...hss........cp.l..p......l..p.sts.............................................................................h..sltpsLphah-lss......s.stt...h.lpt.....hA......ph........s........s.....s...............p..p............................L..t..Lsss...............p.t...p..h.........p..p.a........h..............t...hs.h....l..........-.l.........l................p..............c...a..........s..........s.......s...............p........l............s.h..p...tllphL....Lp.P.RhYSIuS.............S....................t.........h.........t...........s.......s........c.............l.............c....lTVulVca.s........spup.....+..t...GssSsa.........................................................	0	471	808	1178
+2479	PF00890	FAD_binding_2		FAD binding domain	Bateman A	anon	Pfam-B_255 (release 3.0)	Family	This family includes members that bind FAD.  This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.32	0.70	-5.63	63	15429	2012-10-10 17:06:42	2003-04-07 12:59:11	19	132	4737	137	4045	50736	24820	363.40	25	69.86	CHANGED	DVlVlGuGhAGLsAAlphuc.pGh.plsllspstshtu..soshu.pGulshsh...t...t..DshchthpDshpus......sths.cpshsch.hsc.pusctlt.Lcph....Ghsasp........................t.......hhshpth.Gutptp...........................................cshh.sust.......sGpslltshhpps..hph.....lchh.chhstsLlh......p.......su....plpGshlt............psuphh....phtAp.uVllAsGGhut...................sht.ssss..sssGcGhshuhpsGst.lts..hchhtatPsulh....sssh.......hhpcshpu.G..........ulhls.spGcR..Fh.......................s-hsstchlscuhhtpchptsts..........sphaLhhsp.................................................lsscslcpplsthpcpstthhs.......hsshcc.............................P..............lhsss..hashGGltTDhpucs.............tttspslsGLaAsGpss...suuhcGssphuGsuL	...............................................................................................................................................................................................................DllllGuGh.AG..h....t....AA......l.........p........h.........s.......p.......t.......G..........h....p......l..h..l...l.s..+.....s...................h..tu...............po........h......h.....u......p........G.............G..........h............s...........s.........s....h.................................................................................................t.......D..........s.......h....p..........h...h......t......D......s.l..t.u.u..........................................shh..s.......c....p...p...h.....l....c....h........h.....s......p........p.......u.......s....p.....t....l...p......L..tph..................Gh...asp...................................................................................s...........................h....p...h...G..uh.php..................................................................................................................................R.h...h..h.....s..ss..h.................................s..G...p.......t.......l.....h....p......s......l......h......p.p..s.......h.p.ht.....................lph.h...t..ch..h..s...h.c.Llh....p.................cs...................................ps.h.Gshsh....................................................psu..phh............t.h.p.A..c...ulllAoG.G.hut...........................................................................h...h..t....h....s..o.......s....s..............h......s......o.G.c.G.h.s..h.uh.....cs.Gs...t...ht...s................h....-..h......h...Q....h.....a....P....s...s....h.......................ttth.......................................l.h...s..c..s.h..p..s..p...G...................................................u...h.h.....h......s...t.....p.....G...p..R...ah........................................................t-..h.....s.s..+...c......h....l....u.p..s....h..h........p....h.pttts.............................h.h..hL.hsp........................................................................................................................hs......p...h...l...t...p....p....h.....s..t..h........p.h.s.h......t..h......h..s............................h...s.....hpp.......................................................................h.......................................................l..h.P..ss............+a.....s.h.........G.....G.....l........s.s...p.s.ps.....................................................s....l....GLaA....sG.Ess.......suh..H..G..s.s..c..huusul..................................................................................................................................................................................................................................................................................................................................................................	1	1281	2555	3442
+2480	PF01494	FAD_binding_3		FAD binding domain	Bashton M, Bateman A	anon	Pfam-B_549 (release 4.0)	Family	This domain is involved in FAD binding in a number of enzymes.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.95	0.70	-5.40	20	17997	2012-10-10 17:06:42	2003-04-07 12:59:11	14	174	3547	120	7349	32963	12148	284.60	17	67.85	CHANGED	cssVL.IVGuGPsGLhhuthLuptGlc......shll-+hsssssts..RAtslppRTMElLcphGltcchtspusspphhutthtss.........................................................cttscl-....t.sussthsshsQsclE.lLhccApppG.splpauTE...lhuhppDtsGVsuhlp...sctsGpp....TlcucYllGsDGs+ShVRcslGlp.hcGptth..hshhslhhcu.sls.........hhhlhsscssGh.................hltPhps...t.hhhhsshs.phpst..ssphsp--stptlcshsussthss.chpthotashssphAccaRpG.RlFLAGDAAHhpPPsGGhGhNsulQDAaNLuWKLAtVLpGpAsssLLDoYssERpsluppllctu	..............................................................................................................................................................................................................plh.llGu.G...sGhh..........h.....A.............h.....h...L....t....p......t.........G...h.p...........................s.h.l......l......E............p..........t...................................................s................t........s..................s.........l...........t.................t.......s.....h..............p......h..........h..............p.......t...........h..........G.......l........h...p....t.....h............t........t...................h........h..h..................................................................................................................................................t..ht.............................................h....h.....h......h...................p.........t...............h.......t.......t.....h........L.....h................p.....t.....h............t...........s.......h..p...h..h....h..s......t..p.....................l......t....h................t........p........t.....p..........t...............t.........h.........h..........................t.t.........t..................................h...p........u......c........h...l.l.........uA.D.....G.........h........p......S....h....l.....R.........p.......h........h............s...........h......t.........h..........t..............t.............................................h.....h.......h.....h......t...h....h......h....t............h..........................................................h......h............t.t....h.................................................................hh.h.s..h........t.....................................................h................h.........................................................t...t..............................t.....h.........................t.........t..........h....................t.................h........................t............h..........h..............t.......................................................h.........................h.........t...................................................h............t...............h............h..............................h...........t.........................h.............h.........h...........t..........p..........h...............h.............t...............s......p.......l.......h...L..........h.G....D.............AAH...............s......h......Ph........t....G....p..........G....h....s.......huh......p...D....s...h.....L...s........h.....l...........t.................................................................................................................................................................t.........................................................................................................................................................................................................................................................................................................................	0	1974	4250	6144
+2481	PF00941	FAD_binding_5	dehydrog_molyb; 	FAD binding domain in molybdopterin dehydrogenase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1112 (release 3.0)	Family	\N	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.84	0.71	-4.82	94	4901	2012-10-02 01:00:47	2003-04-07 12:59:11	16	65	2185	108	1498	4277	1822	176.00	27	36.83	CHANGED	tphpahpPsolp-hhplht......ttssA+lluGuTslsshhchphhphshl.lslspl.s-Lptlpps..s....sslplGAssohsclhp..........tthsphhs.sLspthptlAu.QlRNhuTlGGNl.............................................ssusshuDhsssLhAlsAplpltssps..pR....plslp-.Fht.....shhpssL.pssEllhulplPhh	.................................................................................................t...pah+Psolpcs....lplhs...............tts..pA..c..l.l..AGG..Tslh...h....h+...h.....p........h....h....p...........s....h....l....lsl.s..p.l....EL...p.t.lp....hs...s....................sulcIGAssshs..cltpt..................................................hpp.t..h.......s...sLs...c..t.h....p..t.h.Au.h.Ql.R.Nhu.....TlGGNl.......................................................ssu.s.s......u....DhssshhAh..sApl......p...l.t....s....sp.....u......pR...........pl.s.lp-..Fat......................s.hcs..sL..ts.s.E...llhulhlP..........................................................................................................	1	466	867	1191
+2482	PF01687	Flavokinase	FAD_Synth; 	Riboflavin kinase	Bashton M, Bateman A, Mistry J, Eddy S	anon	Pfam-B_1221 (release 4.1)	Domain	This family represents the C-terminal region of the bifunctional riboflavin biosynthesis protein known as RibC in Bacillus subtilis.  The RibC protein from Bacillus subtilis has both flavokinase and flavin adenine dinucleotide synthetase (FAD-synthetase) activities. RibC plays an essential role in the flavin metabolism [1].  This domain is thought to have kinase activity [2].	19.60	19.60	20.60	20.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.59	0.71	-4.24	139	4738	2009-01-15 18:05:59	2003-04-07 12:59:11	12	21	4531	30	1203	3417	2167	126.90	37	41.33	CHANGED	hLG+saplpGpVl+Gpph.GRplGFPTANlph....pshllPtp...GVYsspspl...................................ssp..........................................................ha..ulsslGhpPT.hss....pph..plEsHlh................DF.st...-....lYGcplplpalphlRsEpKFs.ul-pLhpQIppDhptu+.phhs	.....................................................................hLG+saplp.GpVl+Gpph.G.Rp.............l.........G.............FPT..............ANltl...............pc.p.hhP.....tp...GVYAsp.l.p.l...............................................s.s.p................................................................................................................................ha....ulssl....G.....h.pPT..h.ss......tch............pl........E.....salh........................................DF...st......D.....l.Y.Gc.p.lpVtahchlRs.Et.K.Fs.u.......l.-tLhpQlppDtppA+phh.s................................	1	411	772	1021
+2483	PF04703	FaeA		FaeA-like protein	Mifsud W	anon	Pfam-B_5784 (release 7.5)	Family	This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase [1,2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.86	0.72	-3.81	5	310	2012-10-04 14:01:12	2003-04-07 12:59:11	7	14	259	2	35	393	13	62.30	35	44.62	CHANGED	MK-cILoalscl.........+uPC+TsEIA-AhGlSAYQARYYLhsLEKEGKI+RSPlRRGAuTLWclpu	..................................scIlpahpp..................pts..s+Tp.-IA-Ahul.o.h.Y.QARtYLhpLEctG..hV..c+..s.ht+Gh..t.h.W....s.................	0	6	14	21
+2484	PF02106	Fanconi_C	Fanconi; 	Fanconi anaemia group C protein	Mian N, Bateman A	anon	IPR000686	Family	\N	25.00	25.00	26.30	26.10	19.80	22.60	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.76	0.70	-6.07	5	88	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	36	0	35	71	0	385.40	44	98.24	CHANGED	MAQDSssLsoNaQFWMQKLSsWsQASTLETQ+DTCLHLuQFQEFLRQMYEsLKEMDSsA.lIERFPTIGQLLAKuCWNPFILAYDESQKILIWCLCCLhsKEPQNSsESKLNSWIRuLLSHlLSu.RFDh..KEVuLFspuLGYsshDYYPuLLKNMVLSLVSELRENHLNGhNoQcRMSPERVpSLSclCVPLlTLPDh-PLVEALLpYHG+EPQElLsPEFFEAVNEAFLpKKISLPsSAVlSLWhRHLPSLEsAsLHLLEKLlSScpNsLRRl-CaIKDSLLPQ.AACHPAIFRlVDEIFRsALLETDGAPEVlAsIQVFTpCFVEALcKENKQL+FALKTYFPYsuPuLlhsLLQ+Pp-IPpGHWLQsLKHIS-LL+ElVEDps+G..SausPFESWFLFVHFGGWlDlAAEQLLhu..AAEPP-ALLWLLAFYYuPpsGsQQRuQTMVElKsVlu+LhMLaRSssLSApDLQAuA.pssuuDsRsPssQQLVRHLLLNFLLWoPGGHoIApElIT+MAcTsAlp+EIIGFLDpTLYRhsHLulEusRocKLARELLcELpsQV	..........................php.WhpKh..Wtps...po.ps..Dss.HLs.hppFlpphhphlpphs......pph..htp..hLtp.C....hhu..tps.phlh...pL.sh.ptcP.sshp.ths.WhpslLsHllos.cht...tEss..hhpsLGYtshDYastLlcNhV.SLspELctsphsths.hp.pRhssp.phhslS.hClPLlTLs-htPLlEsLLhh..putpspEhLt.-Fh-tVs.......-Ahl.c+ls.....L.s.pulhsLWh+aLPSLEpAhLpLh-plhot.p.....pchpphlc-S.LPp.uAppsuIFhlVs-hF.R....sLhEo-Gs.plhshlQlFTpChlpthppps+Q.pasL+saFP.s..sLshsL.hppPp.tlspth..hhp.L.pIophL+phsE-tptt...............u.ts.aEtWFLhlphGtWschssp.Llh......tutss.tsLLWLLsFhatPpsttppRtpphsphp.hhs+Lhhh.t..p.shshtcLptsh......t.t.p.sh..tpLhh+Llhphhlas.tsh.hs.-hlshhh.ptth.pchh.hl.ph...h.h.p...p.t.cs.t...hhppL.tpL...............................	0	5	6	11
+2485	PF03511	Fanconi_A	Fanconia; 	Fanconi anaemia group A protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.90	20.90	21.00	32.30	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.13	0.72	-4.19	2	47	2009-12-01 10:28:13	2003-04-07 12:59:11	9	1	30	0	22	44	0	61.90	56	5.08	CHANGED	REELLlhLFFFSLMGLLSSaLTppsTs-h.KAhclCAtlLpCLE+RKlSWLsLFQLTEpDh+LG	.....EcLLV.LFFFSLMGLLSS+Lssps...ssD..KAl.clCApILpCLE+RKI.SWLsLFQLTEsDh.........	0	1	2	7
+2486	PF01149	Fapy_DNA_glyco		Formamidopyrimidine-DNA glycosylase N-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges [1].	24.40	24.40	24.60	24.50	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.78	0.71	-3.73	109	5183	2009-01-15 18:05:59	2003-04-07 12:59:11	19	13	3625	70	1224	3585	2246	118.40	30	42.40	CHANGED	PELPEVEslpcsL...pp.tlhGppItp.lplt..........psp.lchs.stt......htptlpGpplp.slpRRGKaLlhph......................................................................................ss.........sh.....hLlh..HLuMoGphhh......................................................................................ttt...t+Hs+lh..hph........s.sst.......................pLtasDsR+FGphp	..........................................PELPEVEs....sp+sl......ps...h....lhG...pp..l.p.p.l..t.lp......................s.p..l+h.s.stt..........h.tpLsGpplp.slp...RRGKaLlhch...............................................................................................ps...................st.......slls..HLu..M.sGphpl...............................................................................hstp..s.sp+H.s+..lt...hth............s..ssp.....................................hLh.atD.RpFGth.h.........................................................................................	0	373	766	1025
+2487	PF04750	Far-17a_AIG1		FAR-17a/AIG1-like protein	Mifsud W	anon	Pfam-B_3664 (release 7.5)	Family	This family includes the hamster androgen-induced FAR-17a protein (Swiss:Q60534) [1],  and its human homologue, the AIG1 protein (Swiss:Q9NVV5) [2]. The function of these proteins is unknown. This family also includes homologous regions from a number of other metazoan proteins.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.34	0.71	-5.15	28	524	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	287	0	312	511	38	182.70	21	80.16	CHANGED	hpllhHl............................................hsls.ashhhahhpp.sp.............taG..........G+apaLThlsL...................llpslaaslsllsDl...........pppcpLptl.....tDahhsshuFPlulhVslhFWsLah....hDccLlh.......Pchlsph................lP..hW.............LNHshHThshlhlll-hhhpp+paPp+ht...ulshhsshshuYhhW.lphlhthsG.hWlYPlhstluh.t+llhFshusllhhhhYlhuchLss	.............................................................................................h..............................................................................................hu...........tpa.paLThlsh....................h.hphhhhhlshltph.......................t..t.hhth........c.hhhshs...hsl....thh.......ls.hh.....aWs.lhh.......hs.phlh.......schhc...h................hP..ha.............l.s.hshHshshlhh.ll-hh..h.........t..h.s.....pht..............uhshh....s...s..hshhYhha...lh....h...h..h.............h...s....u....h........asYPhl.p.....hh.s...h......t..p..hh...h..ashshhhhhhhhhhh.....................................................	0	107	159	243
+2488	PF01581	FARP		FMRFamide related peptide family	Bateman A	anon	Pfam-B_666 (release 4.1)	Family	The neuroactive peptide Phe-Met-Arg-Phe-NH2 (FMRF-amide) has a variety of effects on both mammalian and invertebrate tissues [1].	15.00	2.30	15.00	2.30	14.90	2.20	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.70	0.77	-6.28	0.77	-2.59	61	1303	2009-11-03 19:08:40	2003-04-07 12:59:11	11	24	73	0	591	1475	4	10.20	46	34.60	CHANGED	ppcptahRFGR	......t..ptpahRFG+	0	210	278	550
+2489	PF02469	Fasciclin		Fasciclin domain	Bateman A	anon	Pfam-B_562 (release 5.4)	Family	This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.82	0.71	-4.13	122	4881	2009-09-10 22:24:17	2003-04-07 12:59:11	17	137	999	8	2602	4995	1077	128.40	22	47.97	CHANGED	sp...hoshhshlp.....su..sLs.ppL.................ss.s.........shTlFA.PoscAF.........tpl.....stsphptLht....spppLpplLpaHllss.ph..tsssltsh......................tp...............lpo..lpGs......plplshp.........ss.........plplss.......Apls..psDl.tssN.....GllHsIDpVL.lP	..........................................................s..hsphh.th.lp.......ts....sLs....ptL....................................................ssts............................shTl.FA....Po............s.pA.F...............................pp.l........................st..t...t.h.p..tlht...............spptlpp.lL........p....a..H...l..l.....ss...th....hss.s..l.tss..................................................................tp...................................................................................lpT......hp..Gp.............plplshp...............ss..........................................plhlss..................upl.h......p.s..s.l.....s..sN...................G..l...l..Hhl.D.p.VL.hP......................................................................................................................	0	870	1506	2063
+2490	PF02259	FAT		FAT domain	Sonnhammer ELL	anon	(Keith and Schreiber, Science 270:50)	Family	The FAT domain is named after FRAP, ATM and TRRAP.	20.00	20.00	20.00	20.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.01	0.70	-5.47	55	1294	2012-10-11 20:00:59	2003-04-07 12:59:11	18	84	321	0	880	1335	63	334.40	17	12.77	CHANGED	usLussAAWtlsp.W-p..hcphlsshp.........................pss.........cpp...FapAlLul..++sphc...cApphIcpuRpllssElou...LsscSYscuYshllplQ.........hLsELEEhlpap.phspt........spchctl....hpsWppRL.ss.pcsl-lWpcllphRsllls.............................................................sc-shphhl+FApLsRKssphslAp+sLppLht.t............................Pplhhs.h+h.Wtps.......pp...........pcAlppL.pchsp.phspsht.t.tp.ht.t...............................p..s.pp.htt.spLhA..+sahchGpaptpl..............p.ht.pshspllpuYttAsphcpphhK.AWcsWAhhNhcllph.tpt.t...................................................................hhpasssAlpsah+SluLups.....puhpchhRLLo	..............................................................................................................hhhtsuWthsp..Wpt......hp.p..h.lp...h..........................................................................................................................pps..........................cht..hhpuhhul........+ppphp.............................phpph..l.ppu..p...phh......hp.......phss.......hs..tp...s..h..p.pth.s..hlh..phQ...............hLsELc....-hhp.h..h.t...................................................pphptl...............hp.tW.pp..R...L............sh..tsshphh.....ppll...thRphhhp.........................................................................................................................................................p..p..h..p.h...h.l...ch...upl...sRKp.s..ph.p...l.uhptLh.p....lhp.................................................................................................spl...ht.hph.at....t....p...................................................pcAh...phL...p......p...h.p..hhppt..............h.......................................................................................................................................................t.......t....ttphh.u....csa...h..hhupahtph.........................................................pp.pthhp.tap.....t..u..s.ph...p.p..hh.............+...u..........at....t.hu..hh....t.p.hhpt.p.........................................................................................................................................................hphhh..ulpsahculth..spp........tshp.h.RlL...................................................................................................................................................................	0	319	487	724
+2491	PF02260	FATC		FATC domain	Sonnhammer ELL, Wood V, Mistry J	anon	(Keith and Schreiber, Science 270:50)	Family	The FATC domain is named after FRAP, ATM, TRRAP C-terminal [1]. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability [2].	25.20	25.20	25.30	25.30	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.33	0.72	-4.51	141	1318	2009-01-15 18:05:59	2003-04-07 12:59:11	15	61	309	3	915	1361	13	32.60	39	1.32	CHANGED	p.sL.olptQVppLIppATsspNLuphYh.GWsPaa	.......h.sL.sVpsQ.VppLIppATs.cNL.....sphYh.GWssah....	0	330	502	761
+2492	PF00316	FBPase		Fructose-1-6-bisphosphatase	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.09	0.70	-5.61	12	2715	2012-10-02 15:53:20	2003-04-07 12:59:11	15	11	2198	197	881	2125	479	306.40	43	94.95	CHANGED	hTLsphhlppt......usu-.....lstllsulshus+hIuptlp+AuLsp.lGtuuusNspGDtQKtLDVluc-lhhsALcuS.sltshsSEEp--hlsh....stpupasVshDPLDGSSNIDsslSVGTIFuIa................sssssp..shhpsGp-.VAAGYslYGspThLVlohGs..GVptFsLD.s.GpFhLscpsh+lPtcuphauINpuNhpaas.slccaIcchhtstcssp.+sashRYlGShVADsHRhLl+G.GlFlYPust+...spGKLRlLYEstPhAFLhEQAGGtAosG+.cpl..LDlsPpplHpRsslhhGStscVt+hpchhtt.	........................................................................t.TLspal.hp...pptph....ssu-...............Ls.tLl.sslthusKhIsptl...p...+...u..........uL.......s.....s..l..l....G.......t...............u........G...........s........p.....N.l...Q.G...E..s.QpKL..Dlhu...N-...hhhsuLc..sp..s..tlsulA........SEEp..........-..........ch..ls..h.............t..t.....s....p........p.......u...c.YlVhhDPLDGSSNIDl..Nl.S.V.GT.I.FSIa+t.s..........................ssps..spt....ch.L..Q.....PGp.pQVAA.GYslYGsuTh..LVhT..sGs............G....V...p.........s..F..T.....h..........D.....s..s....l.......G............pFh.L..scp.........s..h..+..........l...Pc.c..G..p.........hYulNpGNhhpa.s....s.s.l+cYlc.hpttp..............pust....+sYshRYlG....S.............hVADh.HRsLl+.G.GIahYPustp.........psp..G..KLRL.LYEsNPMAFlhEQAGGt..........Ao...s.....G....p.....pRI...L.Dl...P.p.plHQRsshalGSpppVcclppaht.t.........................................................	0	253	520	722
+2493	PF03320	FBPase_glpX		Bacterial fructose-1,6-bisphosphatase, glpX-encoded	Mifsud W	anon	Pfam-B_3515 (release 6.5)	Family	\N	20.50	20.50	20.60	20.90	19.50	20.30	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.81	0.70	-5.79	111	2306	2012-10-02 15:53:20	2003-04-07 12:59:11	8	3	1790	13	437	1381	1900	308.20	54	95.06	CHANGED	-RsL...ulEllRVTEAAAlAuu+ahGRGDKpsADpAAV-AMRphlsplshcGsVV....IGEGEhDEAPM.LYIGEcVG.s..G..pGPp............lDIAVDPlEGTslsApGhsNAlAVlAhuc+GslLcAPDh.YM-KlAVGP........tucGhlD..lstslp-Nl+slAcAhs.+slp-lTVslLDRPRHpclIcclRpsGARl+LIsDGDVAuulssshsc.o..GlDlhhGIGGAPEGVluAAAl+ClGGphQuRLhs.............ps-pEc.pRspch..Gl...Dh..s+lhsh-DLVpupclhFuATGlTcGsLLcGV+a.....psst.spTcSlV.hRucoGTl.RhIcut..H	.......................RpLAhEhsRVTEuAALAuh+WhGRGDKNsADGAAVsAMRphLNplshcGplV......IGEGE.....hDE..APM.LY.IGEcVGsG......pGs.t................VDIAVDPlEGTphsAhGps.NALAVlAhu-+.....G.....shLc.A.PDM..YM-KLsVGP........tAtG.s..ID........LshPls-NL+sVAcAhu..Ksls-LsVslLc+PRHstlIpEhpphGsRVhhIsDGDVAuuIhTshs-...o.slDlhhGIGGAPEGVl.oAAAl+sLGG-MQuRLls..............h.s-pEhtR.CcpM..Gl......-.ss+VLpl-Dhs+u-..sllFuATGlTsG-LLcGlph.....push.....upTcoLl..hR.u+opTlRhIcohH..........................	0	146	291	369
+2494	PF02634	FdhD-NarQ		FdhD/NarQ family	Mian N, Bateman A, Iyer LM, Zhang D, Aravind, L	anon	COG1526	Family	A pan-bacterial lineage of proteins. Nitrate assimilation protein,  NarQ, [1] and FdhD (Swiss:P32177) are required for formate  dehydrogenase activity. Structurally, they possess a deaminase fold with a characteristic binding pocket, suggesting that they  might bind a nucleotide or related molecule allosterically to  regulate the formate dehydrogenase catalytic subunit [2].	25.00	25.00	27.50	25.80	22.70	24.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.49	0.70	-4.91	203	2755	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	2387	4	651	1935	1212	230.20	33	86.35	CHANGED	spEtPlslhl.NG........pphsshMsoP......................sch--hAlGFLhsEGllp.ssp-l..pulpls.....................................pp............t.p..........................lt...lp.........spt...t..h...cc+h..h..sssoGC........Gh..Ght..h.ph...hpth.h.........s.thplsssplhphhpplpp.tpslappTGulHuAulh..s.....ss..p..llhhtEDVGRHNAlDKlhGthhh.........psh.................s................hs...st.....hllsoGRlSsEMV.KsAphGlPlllohSAsTshAlclAcchGlTLlGhsRs..............pc..hslYot.scRlh	...................................................................................spEhPlslh.h....NG..........h.phsshMsoP......................pclE.phslGF.hoEGlIp.s.c-l...h.ulcls.......................................................ts.sss.........................lcls.........spt......thpt..........pc+th..sspouC...Gh..s..Ghpt..lpph.................hpshp.h................s.sh.phs.hs.p.l.hphhppL.pp....t.pt.lh.pp.TGulHuAAhhs.............ss..p....llsh+EDlGRHNALDKLlGtth.p.....p..s.h..............................s.......hpps..........hll.sSuRhShEhVtKuAhhGlslLhuhSAsTsLAlclAcchs.......lTLlGFs.Rs................sp..hslYotspRl.h.........................................................	0	188	402	541
+2495	PF04216	FdhE		Protein involved in formate dehydrogenase formation	Mifsud W	anon	COG3058	Family	The function of these proteins is unknown. They may possibly be involved in the formation of formate dehydrogenase.	27.20	27.20	28.30	27.90	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.25	0.70	-4.69	49	958	2009-09-11 05:40:51	2003-04-07 12:59:11	7	2	907	2	192	561	21	287.00	48	95.45	CHANGED	L....t.l........t..t.s.lhhss.tslatpR.....ApRLptLApp.pP.hu-YLpahAplscs.Qppl...lpph.shshs.st.h.t......tpuhPsLstpsh.p-stapt..hLptLlsplpst...s.ssshht..slctLcp...ssssplcthussLLs..........tphstsss..shshFlhAALplhasphAst..lstpshst.spp....shCPlCGohPluSllphssp.p.......Gh.RYLpCuLCpoEW+hlRscCssCspocslphhsl............-stps....sl+AEoCssCpuYlKhlh.p-ccsph-sh.ADDLAoLtLDlhh.p-pGapRsuhNPhLh	.............................................................................................................chssscpps...ushIPPLLFPphKslYsRR.....AcR.LRcLA-s...N.........P..LuDYL+FAAhIAcA.Qcsl.....Lh-a...PLp.h.-.ls.s.cl.tcs............pspG.p...PPLDhcs.l.s.R.D..p+.W.pc....LLhuLlAEL+Pc.................hssssLA.......lIEsLEK..............ASspELEshAs.ALhA...........................u-FusVuS......-K.APFIWAAL.S.LYWA....Q..hAsh......IPu+.....A....+..s..........E..aG.....Ep.R....................p.aCPVCGShPVuShVplGss...Q.........G..L.RYLHCsLCETEW.HlV.R.l.K..CSNCEQo.tcLcYWS.L.....................-.sEpA........AlKAESCsDCs.TYLKILY...QE..K...-.....P....c..V.........E.uV.....ADDLASLsLDucM.EpEG.aARSSlNPFLF.................................	0	56	112	156
+2496	PF03147	FDX-ACB		Ferredoxin-fold anticodon binding domain	Bateman A	anon	[1]	Domain	This is the anticodon binding domain found in some phenylalanyl tRNA synthetases.  The domain has a ferredoxin fold [1,2].	21.00	21.00	21.20	21.90	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.85	0.72	-3.81	134	4662	2009-09-10 22:44:18	2003-04-07 12:59:11	9	19	4522	20	1190	3729	2172	94.00	33	12.29	CHANGED	S+aPslpR.DlAlllsp..................sl.sss....plh..pslcpss......sp.hLc.slplFDlYp.G..........ppls.p..scKSlAhplhapst-+TLs-p-lsshhppllptLppchsupLR	........................S+FPuspR.DlAllVs.c........................................................s.l..sss......-lh........psl..cps.u.....................sp.....hLp.....slpLFDV..Yp..G...............cp.ls..p..........GcKSlAhsls.hp..s....s.-+TLs--E.....lstshpcllpsLpcchsApLR.....................	0	404	755	1004
+2497	PF00465	Fe-ADH		Iron-containing alcohol dehydrogenase 	Finn RD	anon	Prosite	Family	\N	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.24	0.70	-5.82	226	13485	2012-10-02 14:41:14	2003-04-07 12:59:11	14	23	3785	67	2682	11831	4421	355.90	25	79.39	CHANGED	P..s.c..lhhG...tG.s.lpplsp..hltph..t........+sLlVo...st.sh..tpt......u.hhcplhp...L..ppsulph.thast.l.pspPshpplpcuhp..hh+......pp..ss.......DsllulGGGSslDsAKuluhhhs.......................................lP............llslPTTuGTGSEso........shuVls..st...ppp..hKh.slts..phhP.......phullDPpLshshPhplsusouhDALsHslEuahs.....................p..ss............s..................hoD...............shuhpulc...hlhptL.ps.hpss.ps.....hpA.Rpph..hhuuhh....A....Ghuh....s...s..uuluh.......sHuluaslu....u.ha.p..............lsHGhssAlh.LPtlh..pash......................tp..htplup...hh.......................sp..............phlptlp....ph..hppl.ulPs.p...Lp-...h.G...ls..p....pp....l....spluptuhps..t..h.s....sPtthstp-.l	..................................................................................................................PtphhhG.tG.u...l.t.p.ls.p......htph....u..........+sllls...ct..slh..p..h...............G...hhsp.lhp....hL..........p..tts....l..p....h.....tla.....s.....t...l....p.s...s......P......o......h.....p.....s......l...p.....c......uh...p......h...h...p.......pt.......p.s...........D...h...l..l.u...lG...GGSs.hD.sAKu.............luhhhp......s.....t............th..............................hP.........................hls.lPT..T..u..G..T..GSEsT.....shuVIo..sp......................psp....hKh..slhs......ph..hP.......s.hullDs....pl.hh.shPtplsA....ssuh..........D..........A..........L..........s.......H.......s....l.......E.u...Y.so.......................ht......uss..............................h.o.D..................sh.u...h..p...ul.c........hl..h.c......t...l.......p....u........l.....p......ss........p....s..................ht..u.....R.....p.....p.....h.....hh.....u.......u.....h.h.......A........G.....h.u.F.....s.......s.......usl.uh................sHuh.u.H..tlu.............uha...c..................................................................ls..HG..hs.sAll....LP..tlh.paNt..............................................s......t+....htph.Ap....hh....................................th..........t.p.t.ttsp....................thlp.tlp............ph...h.p.pl....Gl...Pt..s........Lp-............h...G......lp....c........................pc....l....st....l.uptAhpc.ts....hhs....sPh...s.t.............................................................................................................................................................................................................	0	880	1660	2200
+2498	PF02742	Fe_dep_repr_C		Iron dependent repressor, metal binding and dimerisation domain	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family includes the Diphtheria toxin repressor.	20.70	20.70	21.00	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.08	0.72	-4.29	141	3389	2012-10-04 14:01:12	2003-04-07 12:59:11	10	16	2647	96	811	2165	650	67.10	34	34.92	CHANGED	TcpGcchAhpllR+HRLhEpFLschLuh.sh-clH--AcplEHhlS-chhc+lsphL..shPppsPHGsPI.Pst	.......TpcGcclApplhc+H+l.l.EpFLhphLGl.s.-ps+c-AEtlEHtlS-chlc+lpphl...p.....p.sP........t................	0	307	589	730
+2499	PF01325	Fe_dep_repress		Iron dependent repressor, N-terminal DNA binding domain	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.40	0.72	-4.03	10	3362	2012-10-04 14:01:12	2003-04-07 12:59:11	14	14	2588	94	779	4553	836	59.00	31	32.07	CHANGED	cLscstE-YLcsIYsLpE.spshspssclAEcLsVpPuoVocMlp+Lc+pGYVcYpsY+Gl	....................................shEDYLc.s...I.h..c.L........t.....p.....c....t......s....t....sp...s...s..clApcLsV.S.s.PoVoc.M...lp+L..pcpG..llphp.apu..................	0	286	561	700
+2500	PF02906	Fe_hyd_lg_C		Iron only hydrogenase large subunit, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.14	0.70	-5.15	141	3059	2009-01-15 18:05:59	2003-04-07 12:59:11	9	160	948	10	841	2861	59	227.10	30	56.42	CHANGED	+hVlsplAPAlRsulG-phuh..st...sG+hhuAL+c.LGFc.pVaDssauADlTlhEEusEhlc.Rl.........pp.st.......h..PhhTS.CCPuWlpasE+haP-.llsplSos+SP.thhGsllKs....hhsp......................th......s.spchhsVuIMPCsAKKhEut.R.-hps.......................cVDhVLTocELuphl+............pt.....sIc.hspLtc...pphDts.h.......s...uouuGtl............F.........GsoGGVhEAslRsshchh.........t..ppht.......hph..hRsh.t.....sh+.sphpl..............................................s........l.+lulspGl..t.ssccllcpl..+s.................G.....................c.....tp.......acFlElMACPGGClsGGG..QP	.............................................................................................h..sst....ht..........................................t..hh...t....hh............h...........t...h..........G......ht.............h.h.-.sshst.phsh....tp.Ehhp.+h..................................................pp...tt.................shhoS.sCP...u..alphhEph...........a.P................c...hls.plSs..s+SP.t...................hhGslhKs......hh.s.p...........................................................................................t..h...............s.spclhsVslMPC..hAK.KhEsp...R.s.-.hts.....t....................................................cVDhVlT.o.c....EL.s.p.hlc.............................................pt..........sIs..ht...plts.....pp..h.Dt...h.........................s.......touu...u..hl....................................................................F.........................................u.soGGlhcushp.hht.h....................................................................................................................................h..phshspGh....t.sht.phl.p..th....ct............................s.................................................................................c...........hpal.Eh.sC.....t.GCh.G...................................................................	0	435	630	751
+2501	PF02256	Fe_hyd_SSU		Iron hydrogenase small subunit	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3750 (release 5.2)	Domain	This family represents the small subunit of the Fe-only hydrogenases EC:1.18.99.1. The subunit is comprised of alternating random coil and alpha helical structures that encompasses the large subunit in a novel protein fold [1].	21.70	21.70	22.00	23.20	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-8.88	0.72	-3.96	109	999	2009-09-11 10:48:27	2003-04-07 12:59:11	12	61	583	10	362	911	20	58.20	34	10.86	CHANGED	tssp-h.hppRtpulYphDpph.s...lR+SaENPtlppLY.ccaLs....cPh.uc+uHcLLHTc.Yps+p	.....................t....chhtpRhpuLYptD....pph.....lRpSa-NPtlppLY...c-aLs....cPh.uc+AHcLLHTp.Ypsp.........	0	185	271	316
+2502	PF01032	FecCD	FecCD_family;	FecCD transport family	Finn RD, Bateman A	anon	Pfam-B_377 (release 3.0)	Family	This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-11.87	0.70	-5.60	145	19091	2012-10-02 17:14:55	2003-04-07 12:59:11	13	11	3812	10	3276	15283	1729	306.10	28	92.97	CHANGED	ll..ll....hhlhu...L....hhGsh...tlshtplhpslht..................sshtt.........llhplRlPRhlhAllsGuuLuluGslhQslhRNPLAsPsllGlsuGAulusslshhhh............shhsh............hhhshhAh..lGuhlu...shllh.hlu.......httthsshpllLsGlulushhsulsshlh.hh....s.p..............phpslhhWhhGSl..s.stsappl.hhhhshllhshhhhhh.hu+pLslLsLG-chApuLGlslpph+hhhllhssllsusuVuhsGsIuFlGLlsPHlsRh...lh....G.sshpthlshoslhGullllhuDhluRhlht.PhE.l...PlG..lloullGuPhFl....aLlh+	........................................................................................................h.hhhhhhhu...l........hhGsh....tl...s...h.tp.l.h.p.h.h.ht.......................................ss..tph..................................l.lh.p.h...RlPRhlhullsGu......uLulu.Gs..lh....Q.s...l..h+NPLA.sPsllG..lsuGAu..hu.hsl..slhhh...............................shhsh.................h.h.h..s.....h...h..A.h.....l.G..uhls..............sh.l.l.h..hlu.................t.p.t..t.hs.s..h..p....l....l...L......s......G...l.u...l.u..s.h.h..s...uls..sh..lh...hh.......s...p.................................................php...p..l...h...h...W.h..h.Gol............s...ss......sa...p............p............l..hh...........h.h.....s.hl.l.l....s.lh.h.s....h..h.......h......u.....p.....t.......LslL.s.L.G.-..c..hApuLGls...l...pp...h+...hhhllh..s.slLs......u.....suVuhsG.s.I...u.F.l.G..L.l...s..P.H.l.s.R.h....l.s......G...s.....ct+...hhlP.h.............us..............Lh...G..ull.......Ll.h........u...D....hl...u.....R...h.....l..........h.................Ph.......E.......l....................P.l.G...l.l..s.u.l.l.Gu.P..h.Fl.aLlh+......................................................................	0	941	1977	2706
+2503	PF04773	FecR		FecR protein	Bateman A	anon	Pfam-B_3234 (release 7.5)	Family	FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognises iron dicitrate in the periplasm.	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.33	0.72	-3.76	182	4810	2009-01-15 18:05:59	2003-04-07 12:59:11	8	61	1004	0	1571	4630	1229	97.30	25	26.17	CHANGED	s................plpTs..s........sp.........ptplt...l.sDG.....op.lpLsssopl...............htttppp..lp....LhpGp....s.hhpssp.ssp.......t....Fplpo.s.sspltstG.T..pF..sl..........t..tpsspsp.....lsVhcGpVp	........................................................................t..h.os..h.Gppt.plp..L..s....D..G.......op..lhLsssSpl...................phshshs.pcp.h...lp.............lpG.E........s.hhc...V.....s+..ssp...................pP.......FhV.......po.........s..p.......s.......p.......l..pV...l.G...T.......pF...p..s..........h......tps.stsp........lslhcGpV............................................	0	637	1127	1377
+2504	PF02388	FemAB		FemAB family	Bateman A, Mian N	anon	Pfam-B_1214 (release 5.2)	Family	The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan [1]. These proteins are also considered as a factor influencing the level of methicillin resistance [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.23	0.70	-5.79	46	2929	2012-10-02 22:59:21	2003-04-07 12:59:11	11	8	1044	13	402	2189	375	322.00	26	95.28	CHANGED	losp..............................EacpFsppps..ssahQosthtcl+ttpshpschlGlccspspVhuAs.....lLhpthshhuaphhYhsRGP....lhDasspcLlpaahppLpcasKp......ppuLalplDPhlhhphhstsGc.h......s.psptllcphpplGacapGhsp.uass.hQsRaphllcLcshs--plhp.shspps+pslK+upphGVcl+hl.st.-E.........LstFtclhppT.p-R+sap.Rs.sYYpchhcpa.s-p.uh..lhlAplshpchlppLppphpphpppltphppt.tpp.pp.............Kpps+hpphppphps.ppclpcspchhpptup..lsLAuuLalhpspEshYLauGossc.........apcahushhlQachhph.Ahc+GlshYNFhGIsGpF...spss....GVh+FKpsFNupl.EhlG-FhhPlpPhhYplh.phlc.......K	......................................................................................................s.pEaptaspp....sphh.Qs..t.hhp.h+.....p.s..h..p..s.ph..l.u.lt.p..p...t......t...........l..h.sus..................l.l...hp.........h.........h.....h........h.....hhY....scGP.......lh..Da...p....s.t...p...h.l.phhhp....t....Lp.p.a.h.+p......ppslhlhhc..P.h.....hp.....h......t................................s.pthh...p..hp.p.hG.a...pa..pGhpt...th.ss...Q....c.........a.hh.hh.sl.....p.....t.......h.....s.t.c........p........lhp.ph.s.t.p.t+ptl+....p....s....h....p.....h....G....l..plchh...ph....-p.............hp.hFhpl.....hp.....T...tc...+....c...t...at......+...s.....pY..apphhc.ha...t-p...s......hhlA.lshpph.tplp.p.t..ptphtth.tt.........................pt.pphtp....pp..phtt..ppchtp.......hpth......tp.st....lsluuul.hhh..s....pc.shY..h.h.uGossc.........appa......h..us.hhhpaphhph.u.h.p.p.s.hs......hYshh.G.lps.th..................st.p.s......GlhpFKpsa..s...s......l....c...hhG.cF..hshp...hYthh.phh.....................................................................................	0	151	260	364
+2505	PF04023	FeoA		FeoA domain	Bateman A	anon	COG1918	Domain	This family includes FeoA a small protein, probably involved in Fe2+ transport [1]. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators.  This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.45	0.72	-4.01	284	5362	2012-10-01 19:11:18	2003-04-07 12:59:11	9	18	3214	52	1271	3443	369	72.70	22	50.92	CHANGED	hsLsp..lp.G......ppspl......tp.lpt..........p................................tthh............p+..LhshGlhsGsplpllp.ps.h..ssslhlpl....................p.sp.......h..s.LppshAppIhVch	..............................................Ltp..hpsG...ppspl..pp..lpt......t.............................tstht...p+LhshG...lh.Gsplpllp.ts.........sh......ssPlhl.pl...................................c..st...p....l...s..LccptAptIhVp................................	0	485	947	1153
+2506	PF02421	FeoB_N	FeoB; 	Ferrous iron transport protein B	Bateman A, Yeats C	anon	Yeats C	Family	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.71	0.71	-4.95	147	3662	2012-10-05 12:31:08	2003-04-07 12:59:11	13	24	2856	55	802	32060	12341	155.20	43	23.61	CHANGED	hplALsGNPNsGKTTLFNsLTGup.Q+VGNWPGVTV..EKKpGphp...h......ps.pph.pllDLPGh.....YSL....os..hS.-EtluRcall.....pcc.sDlllNllDAoNLERNLYLThQLlEhs.hPhllALNMhD.AccpG.hpIDhppLpchLG.lPVlsssApcspGlccLhctl	...........................................................................h.pluLlGNPN..sGKToLFN....t....L...............T...........G........u...........p............Q.......+.............V........G.......N.......W............s......G........V........T..........V........E......+....K....p....G..p....h..p......h........................ts......p..p.......h.....p.l..l..D........L.......PG.s............Y...S....L..................ss....h...S..........-......E.....p......l......s.....p.....c.....a.....l.l...................p..p.....p......s...D............l.....l............l............N.........V.....l............D..............A............o.............N.............L.............E............R.............N........L................a..........L...........T........h.......Q..........L...........l...........E..............l............s............h............P......h......l.....l..........u......L...N.M...h.D...h.............A...........c...........+...........p............G........l......p.........I.........D...........h..........c...........t........L.......u.........p.....p......L............G...........s........P.........V.......l.......s....l...s.A.pc..s..c..G.lcpLhpt.h.........................................................................................................................................................	0	308	571	698
+2507	PF00142	Fer4_NifH	fer4_NifH; 	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	Sonnhammer ELL	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.62	0.70	-5.21	14	20327	2012-10-05 12:31:08	2003-04-07 12:59:11	13	8	3168	72	446	26260	3397	132.50	67	98.47	CHANGED	RpIAIYGKGGIGKSTToQNhsAALAchG.K+VhllGCDPKADSTRLlLtGKsQsTll-hht-cGt..E-lpl--VlhpGatslcCVESGGPEPGVGCAGRGVITuIshLEE.GAYs.D.lDaVhaDVLGDVVCGGFAMPIR-sKAQElYIVsSGEMMAlYAANNIsKGlhKYAcpGG.VRLGGlICNuRpsDpEpEll-paAcplGophIHFVPRDNlVQ+AEhp+pTVhEasPpss....QApEYRpLA++Ih-Nc..hlIPpPloMD-LEsllhcaGlhc	...........................................................................................................................................................................S..T...R...L..l..........L...p....u.......K....A....Q.....s......T.............l........L..............c....h........A.u.........E..............t....G..s..........V......E...............D............L........E..........L....E....D..V....h......+.......h........G......Y.........t.....s............l.......+......C.....V....E.....S...G...........G...P.....E.....P.....G.....V.G...C...A.......G......R....G....V....I...T....u...I....N......F.....L...E....E....p....G....A..Y....-.......-.........l..DaV....Y.D...V........L.G...D....V...V...C..G....G..F..A...M..PI.R...E....s......K...A....Q.E.I.YI.V.hS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	138	291	373
+2508	PF01794	Ferric_reduct		Ferric reductase like transmembrane component	Bashton M, Bateman A, Finn RD	anon	Pfam-B_728 (release 4.2)	Family	This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane [1]. The Frp1 protein Swiss:Q04800 from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake [1]. Cytochrome B-245 heavy chain Swiss:P04839 is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants [2]. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterised by the absence of a functional plasma membrane associated NADPH oxidase [3].  The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease [4].	24.30	24.30	24.30	24.30	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.97	0.71	-4.04	209	4658	2012-10-03 10:28:09	2003-04-07 12:59:11	14	103	2096	0	2249	3954	660	129.60	19	25.54	CHANGED	tGhh.uhhhhshhhl........lu...h+....s.h....htthshpp....hhh.hH+hluhhshh.hshlH...........shhahhhhh.......................................tthhtthhtp.hhh.......................hGhluhh.......................................hhhhlhlsS......hthhR.+hs............YchahhhHhl.hhh.............................hhllsh	.....................................................................................huhhhh..shshl................................ls...h+.........s.l..........h.tt.h.s.hpp...........hhh..hH+h.........lG......hhsh.h..hu....hlH............................sh.sah.h.h..h.hh...........................................................................................hhtth..h..p..p..s.hh.h............................................................hGh...l...u.hl...........................................................................lh.hh.lhh.sS...........hthh.p...+hs................................................achahhhHpl..hh.lhhlhh.h.............................................................................................................	0	573	1182	1798
+2509	PF00762	Ferrochelatase		Ferrochelatase	Bateman A	anon	Pfam-B_879 (release 2.1)	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.91	0.70	-5.46	217	4061	2012-10-01 23:23:09	2003-04-07 12:59:11	14	15	3675	58	1013	3123	3342	305.40	29	88.92	CHANGED	+hulLLlNlGsP-ss..psVc.aLpp...hh..sD.cllc...lP......hh..hLtthIh.hRst.cssctYppl..s..s....sSPLhthTcpQsptLpptLspt..........................p..h.VhhuMRY.spP.l.pcslpplpp.p..Gs.....ccllllPLYPQYSsoTouoshcpltcsh..tp..............ht..sp....lc.hlpsaascPsalpAhspp....lppthpp.h..............tp.........spLlhShHGlPpph.l.ptGD...............................P.....................................YtppsppTs....chl.tct........................................L.....shpp................aplsaQSR.hGs..tcWLpP.TsctlcpLspp.G.h..+plhlhs.uFsuDplETL.ElshEh.+-hhtctGs...ppaphlssLNssstalpsL...scllppph	..............................................hulLlhNhGoP-s....psVctaLpphh..pD.p.+llc......hs......h..hlt..hl......hRst.cl.............sctYppl.................s.....ssSP..Lh..........th.o..c...pQ.sp...tLpptLsp...........................................p.h..Vhhu..h.+Y.usP..l.ps...sl.pphp.t..p...Gl................cc...llll..sL..YPpYS.soTsuush-pltchh....tp...........................h...p.....lphl.csaaccs.taIpshupp....lppphtph..................................tc............shLlhShHulPpph.h..ctG.D...............................P................................................................Y.ppspcTs.......chltpt.............................................L...............shsp........hthsaQ.S+.hG....t.WLpP.sp-t..lcpL......scp.....G...h.............cplhlhs.s....uFsuDplETL.ElshEs..+....c.hh.h.....ch..Gs......paphhsslNssstaIchlsslltt..h................................................................	0	298	610	840
+2510	PF04060	FeS		Putative Fe-S cluster	Bateman A	anon	Bateman A	Domain	This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.	20.50	20.50	20.50	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.70	0.72	-4.37	19	2487	2012-10-03 08:56:42	2003-04-07 12:59:11	8	151	1933	7	725	1862	213	34.40	47	12.10	CHANGED	lLPpoNCGpCGassChsaAptllpscsclscChsh	........lLP.psp.CGpCGY.P.GCcsaAcAl.s.p.s..t.s.p.l.spCsPG................	0	301	522	632
+2511	PF02941	FeThRed_A	FeThRed; FeThRed_beta; 	Ferredoxin thioredoxin reductase variable alpha chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	25.20	31.40	24.70	18.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.12	0.72	-4.04	17	112	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	88	8	52	119	22	69.00	49	52.62	CHANGED	lGDRVRVpsSVlVYHHPpHRspsFDlp.GhEGEltsllspWpGRsISANLPhhVpFs...........KF+AHL+--E	...lGcRVRVpss.VhVYHhP...+stshDlp.GhEGcVtp.hl...spW+G+...lSANLPhhVpFph..........+Fh.AHL+EDE....	0	12	35	45
+2512	PF02943	FeThRed_B	FeThRed_alpha; 	Ferredoxin thioredoxin reductase catalytic beta chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	19.30	19.30	19.50	23.60	17.80	16.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.48	0.72	-10.95	0.72	-4.34	20	255	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	215	8	133	258	35	99.20	36	71.12	CHANGED	csLEsh+KFuEpYAK+oGTaFCsD.uVTulVlEGLA+HK-phGusLCPCRHY..EDKpuE.VtssaWNCPCVPMRERKE.....CHCMLFLT....P-N....FuGppQcIsp-plpcpp	..............h-hh+cFs-paAc.+sGhaFssDtslTssVl.cGLucpK-chGtshCPCRhh..-c+pt-...pt.h.CPCl.hREc..c..........CHChLFlo........-.........t..............t................................	0	48	107	123
+2513	PF01846	FF		FF domain	Bedford MT, Bateman A	anon	[1]	Family	This domain has been predicted to be involved in protein-protein interaction [1]. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions [2].	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.44	0.72	-4.01	149	2377	2009-01-15 18:05:59	2003-04-07 12:59:11	14	41	279	21	1493	2278	3	52.50	24	17.77	CHANGED	cscpsFp.pLLc-tp....lsspo.........pWp...chhp..hl.ppDsRa..hsl.....pstpc+.cplFpca	...............tcpsFp.plLc-.tp............lsspo......................................pWp.....chhp......hl.t......p.....DsRa......psl......tstp-R..cplFpca.....................	0	421	703	1108
+2514	PF05013	FGase		N-formylglutamate amidohydrolase	Bateman A	anon	COG3741	Family	Formylglutamate amidohydrolase (FGase) catalyses the terminal reaction in the five-step pathway for histidine utilisation in Pseudomonas putida. By this action, N-formyl-L-glutamate (FG) is hydrolysed to produce L-glutamate plus formate [1].	20.40	20.40	20.60	20.50	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.41	0.70	-4.46	188	1531	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	783	10	479	1356	624	215.20	26	74.23	CHANGED	sss.lllsssHuGptlP..ssh...thshs.sthth+huh........Dhhscplhpths.th.....sAs..........lltuph....SRhllDhNRss.chsshh.........................stsshshlP....s...sp.lh.....thsts-tppRlpphapPYHsslsphlsphpsp.hshshllssHShsshh...sh.............shplGshas............s...ss....plspthhsthp......ssh.............s...lspNpPYsG.uhhspt...htt.spGhtslplElppsLhhs	.........................................p..PlllsssHuGpplP..ssh.....thshs...stht.p.hst.................DhalcpLhpths.th.....sAs..........hlt.upa......uRhllDh.NRss.chs.h...........................stustshlP.....s...s.p.hh..........t.sss-ttpRlpphapPYHpslpthlschpsp.aGhslll-sH.Shssh..h....shh..................hssasl..Gsths..............st..ss....plspthhphhp......sts..............hs.sshNtP.apG..uhhscp........hststpshp..ulplElppshhh................................................................................................	0	118	271	364
+2515	PF00167	FGF		Fibroblast growth factor	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors.  These receptors can each bind several different members of this family.  Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular [2]. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.52	0.71	-4.34	77	1638	2012-10-02 19:42:32	2003-04-07 12:59:11	13	13	202	252	751	1462	0	113.10	32	52.07	CHANGED	RhtpLYsps..saaLplhs.....sG....pV.sGoppc..sstaulLplpus....sh.G..hVtI+usposhYLsMsccGcLY.......u...s..........pphs.s.-ChFpEph.-NtYssYtStha.....................tcshaluls+pG+s++Gp..+s...+ptppsspF.....L	................................................................hpLaspp.....uhaLpl..s...............sG...............pl.s..G...s...p..cc.............ts....a...s...h.....l.pl.sl....................sh..u...hVs..I.pGlp.o.shY.lsM.N.p.c.G.cLa.......u....o..............................pp.hs....s..-ChF..p.E...pl.....E..N.t..YssYtStha.....................................ptaaluLs+p.G.pshcGp...+s+.tp..spFh....................................................................	0	98	159	373
+2516	PF00370	FGGY_N	FGGY; 	FGGY family of carbohydrate kinases, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.34	0.70	-5.06	13	14797	2012-10-02 23:34:14	2003-04-07 12:59:11	16	35	4137	100	3453	10824	3157	231.80	24	48.40	CHANGED	hhlGlDpGTousKAllhs.cpGcllustptphshhpPcs..GasEpDPc-lapsstpslppllppt....tho.ppIpuIulouQt+uslllDcps.cPLhsAIlWsDsRTsshscpLpc..phs.pplhphTG.shhshaolsKLpWlp-pcPchhcphc....pahhs+-YLpa+LTG.....pasTDhosASsohhaslpstcWDcplLphlGIs.s...hLPpllpouclhGplpsphAthhGh..slPVsuGuuDssuuslG	..................................................................................................hlulDhGTous+..s..l...l.....h.........s....p.......p.....G......p..............h....l.......u.......t......t.......p...t....t....h......p...............h......h......s......p.s................G.a...s....E.........p.......c........s..p..........p.........l...a...p...s.....h...t...p.s....l.p...p....s...hpps........................th.p....p...p.......l..t....uI...G..........l..........s.........s......p..........t.......c........s..........h..........l..l.........h.............D.........c...........p..............s....p...............s...................l..................h...........s...........s...........I...................s................W.p..D..p..R..s...s..p...h....s....p....p........l............p...............p..............t....h.................h.........t................p..............t...........l................h................p................h........o.........G................h...........................h.......t................s..........h......h................s......h...s......K.........l.h.....Wl....h.c...p......s.t...h..h....p.p.sp................hhh.h.h....s.sa.lh..a..p.L..T.G....................t.h.s..s..D....h.....o.s..A..u...p.....T..h..h........h..........s.....l.....p..........p......h..........p........W........s........p........p........l........L...p.....h..........h.......s.......l...s...pp..................hl......P......p........l.......h......p........s...u.....p..h..h.G.....p.......h............p...t.t.....h.............t.............t....h....h.....u...................................................t..............h...P........l.s.s..s.s.sDptuuhhG...............................................................................................	0	1153	2092	2847
+2517	PF02782	FGGY_C		FGGY family of carbohydrate kinases, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.30	0.71	-4.70	105	14710	2012-10-02 23:34:14	2003-04-07 12:59:11	11	34	4144	98	3368	11639	3173	190.40	23	38.30	CHANGED	hthshGToshhhh..ts........spPh...tspuhhsshs...........................s..........shhhh-GspsssGslht.alhp........htthtpttt...................p.hst..t..ssss.s................sthhhh.....Psh.sGpts......Phhsspttusl..................hGhs.sps....huphhpuhlEuluhthRthlcth............tp.......................uts...hsslhhsGGts.cssllh.Ql..................hADshG..hPlhhsps.s-usslGuAhlu..uhAh	...............................................................................................................................h.ohGTushhhh.....ss............pp.sh........s.pu..h..h.s..s.hs..................................................s.tas...h.p.G..s.h.h.s.u.Gs.s..l.p....Wlpct.h................th......h.tpttp.........................p.hs.................p.ts...ss.....................ss.l.h..hl..........Phh..sG.....ts...............P...h.h....s..s.ps+..G......s.h.................................hGl.o...h.s.ss..............ps.clhR...A...s.....lEu....l...u.a...p...h..p.s.....s.l.csh.........ppt........................................................................Ghp........hpplt.l..sGGuu...pssh.h.h.Q.h..................h.ADlhs.......hsl...h............sts...t......E...ssALGAAhhAulu.............................................	0	1123	2048	2789
+2518	PF00498	FHA		FHA domain	Finn RD, Durocher D	anon	Prosite	Family	The FHA (Forkhead-associated) domain is a phosphopeptide binding motif [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.42	0.72	-3.85	221	10726	2012-10-01 21:55:46	2003-04-07 12:59:11	21	374	2041	93	5327	10014	968	70.70	25	13.00	CHANGED	hplGRs...........ts.s-ls...ls..............s...tt.lS+pHut...l...phpss.............................phhlpD.....ht....SsNGT.al.....Ns......pplpt.................hpLpsGDh.lplG	...............................................hlGRs.....................ts..s..c.lh.......ls.................................s......t..lS.+.p.Hup...l......phpss.................................................................phhlpD...............................hs..........SsN.G..T...a.l...........Ns.............pplpp............................h...Lp.sGDh.lplG...............................................	1	1945	3258	4503
+2519	PF00771	FHIPEP		FHIPEP family	Bateman A	anon	Pfam-B_983 (release 2.1)	Family	\N	20.50	20.50	20.80	23.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	658	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.96	0.70	-6.20	180	3878	2009-01-15 18:05:59	2003-04-07 12:59:11	15	8	2246	8	680	2701	953	594.50	38	94.91	CHANGED	sIlshhllPLPshlLDlhlshNIslSlllLhlulalp+PL-FSsFPolLLlsTLhRLuLNlASTRlILhpGc......AGcVIpuFGpFVlGG.....NhlVGlVlFlILsllpFlVITKGupRlAEVuARFTLDAMPGKQMAIDADLNAGlIspc-A+pRRpclppEucFYGAMDGASKFV+GDAIAGllIhhINllGGlhIGlhQ+shshucAhpsYolLTIGDGLVuQIPALllSsAAGllVTRsu.spp.....shupplhpQlhspP+sLhlsuullhhhullPGhPplsFlhluuhhuhhuahht+pp................................................ttttttsttpt.................tttttpshpshhps-...sltL-lGasLlsll-tsp..sut.LhpRlpslR+plup-hGhllPsl+l+Ds.hpLtssp....YpIplpGlplupuclhsschLAls..ssts..t................pl.sG..htsp.....-PsFGhsAhWIstsp+cpApttGa.............sVVDssoVluTHLscll+ppus-LlGhpEsppLl-pl........ppphPcLV-El.hPchlsluplpcVLppLLpEpVuIRcltsIlEsLs-hu.sps.cDsthLsEhVRtuLuRtIs....pphtss...p.spLsllsLssplEphltpul.pp.tsts.s.......hlsl-Pshsppl..lpplppth...pp.htt........tGtssV.LlsusslRhhlp+llcphh.s.plsVLSasElsssh.pl	....................................llshhllPLPshllDhlhshNIslulhlLhluhahpcsL-FusFPolLLlsTLhRLuLNluoTRlILhpup.................AGcllpuFGpFVlG.G......NhslGlVlFhILhllpFlVITKGupRlAEVuARFoLDuMP..GKQMuIDA....DLsAGlIspppA+pRRpclppEupFYGuMDGAuKFV+GDAIAGllIhhINllGGlhlGhhQasMshupAhppYolLTIGDGLVuQIPuLllShAAGllVTRls..ssp.........shupplhpQLhs.pPp.slhlsuu.lhhlhul.lPGhP....p..hsFlhhus.hlhhh..u.ahh.ppct....p.......................................................t..t......t..p...t..t..t..h.p..t.............ttpttp.t..sh.ss.l.........h.-....sl.tlclGh.p.Llshlctt.p...ttp...L....h..p+..I...cslR+phup-hGhl.hP..l+l.........R...-s..hpLpssp....YtlhlpGlplup.uc.lhssphhsls.......su.ps.hs................pl..sG........sh..............-.P.s..a.G..h.....suhWIpt.s.p..ppAph.Ga.............sVl.-.ssoVlsTHLscllpppss-lhGhpEsppLl-pl........pp.phPcLl--l.h................p..hlslspltcVLppLLpEplsIRDhtoIhEs....Ls....-hu...sh..........p....pD..s.hLsthVRhuLtRtIs....p.ph.h...s.s..........t.spl...plltLssplEphlhp.ul..pt..t..t..tu.t.........hhsl-Pshspplhpphppth..pp....t................h.u.t....ssV.LL..s.s..slR.hlp+hlct..h..s..pl.VLSatElssphp.............................................................................................	1	210	402	531
+2520	PF01269	Fibrillarin		Fibrillarin	Finn RD, Bateman A	anon	Prosite	Domain	\N	19.90	19.90	19.90	19.90	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.40	0.70	-5.44	42	616	2012-10-10 17:06:42	2003-04-07 12:59:11	12	7	468	19	394	756	165	215.80	57	78.68	CHANGED	lc.H.+atGValsc.sctst..LsT+NLsPGppVYGEKhlphpsp...........EYRlWNPaRSKLAAAIlsGlcph.I+.GuKVLYLGAASGTTsSHVSDIVG.cGhVYuVEFS.RshR-Ll..shuccRsNllPIltDARpPpcYRhLVt.hVDllFsDVAQP-QAcIluhNAcaFLKsGGahlluIKApsIDsTtsPctVFtpElpcL+c...pshcsh-pl.sLEPa-+DHAhVlGha+h	...........................................................cPH.+atGVFls+.G+cDh..LsT+NhsPG.....cuVYGEKRls..l..pss................spKhEYRlWNPF..RS..K...LAAu.Ilu.G.........l-p.la..lcPGuKVLYLGAASGTTVSHVSDlVGP................pGhVYAVEFS+....R...s...G...R..DLl..s.h..A..c..+...R......s..Nl..lPI...l...E...DA.......R..+...P...t.+Y...R.M...L...V...........s..MV..Dl..I.F.u.D..VA..Q...P............DQA.RI.l.ul.N.A.chFLKsGGth.l.I.S....I.......KAsCIDS..Tss..s..E..s.....VF...A..........p.EV..pKL...pp...-phKPhEQl.oLEPaERDHAhVlGhYp.....................................................................................................................	0	137	227	320
+2521	PF00147	Fibrinogen_C	fibrinogen_C; 	Fibrinogen beta and gamma chains, C-terminal globular domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.82	0.70	-4.76	11	4781	2012-10-01 23:56:02	2003-04-07 12:59:11	13	214	1032	239	2185	3828	41	153.80	35	42.42	CHANGED	.s+DCp-lhpp..GucoS...thYhIpPcssp.cshcVYCDMcT-sGGWTVhQpRpDGSlsFtRsWcsY+pGFGNls............sEaWLGNDpIppLTptG..shcLRl-LcDapG-pshAhYssFpVps-ss+YpLpVssYpG.sAGsAh........stscoMThHNGMhFSTaDRDND.....ssptsCupp.uGG...WWYspCHuANLNGhYYaGushshp........sGVsWhsWKGp.........YSh+pspMKlRPh	.............................................................................s.......thh...l...........................................h.......shC.-........p............t...s.....G.....G....W.h.....l.h....Q....p...............R...............s......G....p........s.....F.......c.t.......Wt.......p.Y.p...G.F..G.p.t................................sEaW..l....G..ctlh....lT......t..t..t................t...........Lh.lp..h......t....s......h.............s....p............h..............h.A........Y.....t...........tF...........l.....t.....s.....tt.p..Y.t.L.t.l..t..t....a...p....G.............................................................p..ps..h.FST..h.D..p........DND............................t.tp.C.u................t.....G..u.....WW.a.......p....t.....C....h..........s....p.....G....................................................................................................................................................................................................................................................................................	0	849	987	1634
+2522	PF03516	Filaggrin		Filaggrin	Griffiths-Jones SR	anon	PRINTS	Repeat	\N	25.00	25.00	27.30	25.00	18.30	24.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.81	0.72	-3.51	10	278	2009-01-15 18:05:59	2003-04-07 12:59:11	8	19	11	0	38	231	0	53.10	57	24.32	CHANGED	-uSRpSsu++HthSo+...ADSSRHSpsGQGQuuuu+o..SR+.pGSSsSQDSDSEGH	.....-tuRpSsuc+Ht...Sp+....ADSSRHStsGpG..Q.uS.uuhs..St+.pGSSsSQsSDSEGH...	0	23	23	23
+2523	PF00038	Filament	filament; 	Intermediate filament protein	Sonnhammer ELL	anon	Prosite	Family	\N	40.00	40.00	40.00	40.00	39.90	39.90	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.07	0.70	-4.96	33	4874	2009-01-15 18:05:59	2003-04-07 12:59:11	16	38	268	31	1988	4185	5	271.60	33	60.33	CHANGED	sEKcphQsLNDRhASYI-KVRtLEppNptLEs+lpphppp..p.....tspssphtshYppplp-LRppl-shst-+u+lpl-l-Nhptsl--h+pKaEcE............................hshRpssEs-lssLR..............+slD-toLs+lDLEt+lESLpEElsFLKphHEEElp-Lps....plp......splsVEhDs.s.phD....LsphLp-lRuQYEslAp+N+p-AEphYpsKhpcLppssspss-tlpsuKpElsEhRRpl...QuLphElpu....lpupppuLEppltEsEpRastplpshQstlspLEppLpph+p-MtRplpEYQcLLsVKhALDhEIATYRKLLE.GEEsR	.................................................pEKtphptLNs+h.A.sa.l.-.K..................V..R...LEppNt....L-...schp.h.pp...........t..t...s..t.....sha...t.l...p........p..L...+..pp.............l...phtt-p......u...pl..h.plcs.h...p..th-...........c....h..+..t...+..a.Ep.E..................................................hsh.R.p.psEs-h..ssl+.................................................................................................+..slD.p....h.hhs+s.-..LE....tp....l-uLp......-.El...t.a.......L.+.p....a....-...c............El....p..plps.............plt.......spl.l...c..hD...s......s....p...D..............Lsp..hl.t..-...l.R.......s......Q.Y..E.p.l.s..pp.....s..+..t....-...s..E...p.h.a...p.........s.+..................h...............p...c.....lp......t....p.s....s.p......p....s....-.t.l.........p..ps.+.p...E.....l......p.......E...hp....+p..l.................pp.L..ph.El..ps...................................hp.s..................p...ts..L.Esplt-sEpphp...h.tl.pphps..h....lspLEt........pLpp.h+p-h..t.pphpE.Y....p.p.LhslKhtL-.hEIu.TY...R..+LL.E.GE-t..........................................................................................	0	179	311	802
+2524	PF04732	Filament_head	filament_head; 	Intermediate filament head (DNA binding) region	Kerrison ND	anon	DOMO:DM04896;	Family	This family represents the N-terminal head region of intermediate  filaments.  Intermediate filament heads bind DNA [1].  Vimentin heads are  able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis [2].   Phosphorylation of the head region can affect filament stability [3].  The head has been shown to interaction with the rod domain of the same protein [4].	21.80	21.80	22.10	21.90	21.00	21.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.68	0.72	-3.28	45	462	2009-09-11 21:54:48	2003-04-07 12:59:11	9	4	64	0	185	404	0	84.80	31	16.72	CHANGED	tssSSYRRhFGs.............sts.p.uhss...st..ssuSshp...spps.psosu...s......pShttps.sssh...h.........-s.lDFSh.usAlNs......EFKtsRT	...................................psSSYRRhFGs.............shs.phuhss.........usuS.uhp.........spph..psSsu....ss.h...u.Sh..ptpsssssht......h.s...............-s.LDF.S..usAlNs......EFKsoRT..	0	6	27	78
+2525	PF00630	Filamin		Filamin/ABP280 repeat	Bateman A	anon	Prosite	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.48	0.72	-3.44	132	7961	2012-10-03 16:25:20	2003-04-07 12:59:11	14	217	181	75	3933	8351	79	92.40	27	39.51	CHANGED	sscssc.sps.....G.G.......l..pts.....hss.pss..pFplpsp.....ss.Gt...t........t....lpl......................tsspst................................................................................................................................................................th.h.....t...lp-pp.....................cG..sap.lpY.pPpps..Gp.aplpVph....ss.......p.plssS.PFp	......................................................................................................................................................................................................................................................s..sspclps............Gs.G...................L....pts..........hss..pss...pFslpsp...............sAs.s.s...................lt.......lpl...............................puP.sst................................................................................................................................................................................................hch....p.....lp.-.s..t...............................-.G.....o.a..s..VpY....h.P.p...p.s.....Gp..a..........pls....Vpa.....ss...................p..cl..P..s..S.PFp.............................	0	1135	1433	2563
+2526	PF01611	Filo_glycop		Filovirus glycoprotein	Bateman A	anon	Pfam-B_1023 (release 4.1)	Family	This family includes an extracellular region from the envelope glycoprotein of Ebola and Marburg viruses. This region is also produced as a separate transcript that gives rise to a non-structural, secreted glycoprotein, which is produced in large amounts and has an unknown function [1]. Processing of this protein may be involved in viral pathogenicity [2].	25.00	25.00	176.80	176.70	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.08	0.70	-5.66	6	92	2009-09-10 21:45:54	2003-04-07 12:59:11	11	1	25	6	0	98	0	322.40	54	65.93	CHANGED	+KTSFFlWVIILFQ+shSlP.LGlloNSTLQso-lDphVC+D+LuSTsQL+SVGLNLEGsGVATDlPoATKRWGFRoGVPPKVVsYEAGEWAENCYNLpIKKPDGSECLPsPP-GlRsFPRCRYVHKlQGTGPCsGslAFHKpGAFFLYDRLASTlIYRGssFAEGVIAFLILsKs++cFhpSpPh+EssNhTpsooShYaToolpYphssFGspposhLFclsspTaVpL-ssaTPQFLspLN-TIppssphSNTTG+LlWTlsPslD........oshGEWAFWETKKssocphpucohLSh.hhps+T.......pNhScpuss.....+pohpPus..ssTst.....ssppsssh.plPhpshpsssoppphpss.p	.............++TSFFlWVIILFQ+shShP.LGllpNSTLpso-lDphVC+D+LuSTsQL+SVGLNLEGsGVATDlPoATKRWGFRoGVPPKVVsYEAGEWAENCYNLpIKKPDGSECLPssP-GlRsFPRCRYVHKlpGTGPCsGshAFHKpGAFFLYDRLASTlIYRGssFuEGVlAFLILscs++cFhpS+Ph+EssN..hTpssoStYaToolpYphssFGsppophLFclsshTaVpL-spaTPQFLhQLN-TIh.tssphSNoTG+LlWplsPplD........sslGEWAFWETKKs..pphhspp.lsh...pstt.......ps.stt........php.pstp...sTs......s.p.p..h.p...t.hpt..pp........h...........................	0	0	0	0
+2527	PF02097	Filo_VP35		Filoviridae VP35	Mian N, Bateman A	anon	IPR002953	Family	\N	22.40	22.40	54.20	53.70	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.96	0.70	-5.23	4	107	2009-09-11 13:24:37	2003-04-07 12:59:11	10	2	30	27	1	61	0	190.00	70	95.46	CHANGED	h.GPEhoGWlSEQLMTGKIPlo-lFsDl-NpPs.h.hphhspspsss+ss....sppoQTDshhs..hccVcpTLssLloslpRQssAIESLEsRlTT....LEsuL...KPV.DMuKTISSLNRuCAEMVAKYDLLVMTTGRATATAAAs-AYWsEHGQPPPGPuLYE-sAl+uKlcs.sshVPpuVp-AapNLsSTosLoEENFGKP.ISAKDL+pIhYDHLPGFGTAFHQLVQVICKI....GKDsNhLDhIHAEFQASLAEGDSPQCALIQITKRlPhFQDssPPlIHI+SRGDIPRACQKSLRPVPPSPKIDRGWVClFphQDGKTLGLKI	......................................................................................................................................................................................................................................................LALLLFTHLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFH....QILSEGENAQAALTRLSRTFDAFLGVVPPVIRVKNFQTVPRPCQKSLRAVPPNP.T.IDKG.................	0	0	0	1
+2528	PF00419	Fimbrial		Fimbrial protein	Finn RD, Bateman A	anon	Pfam-B_196 (release 1.0) & Jackhmmer:B2PIN3	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.27	0.71	-3.98	244	16321	2012-10-02 17:35:21	2003-04-07 12:59:11	15	9	786	91	829	6504	36	150.30	18	66.83	CHANGED	lshpu.sl......tsssCsl....s..ssss...................VsFG.slsh..s..plsss.........tht.pshslsls.........Csss.................slpl.thh........us.....ssshs..ssslts....sss..................slGlpl.......................................pps..ss.....h...................t........thsphhshshs.............hpAs.hp..tsssshs.t....GpFsAsuolplsY.p	...................................................................................phpG.pl......hsssCs...l........s..ssst...............sV.sh...G...plss.......s....phpss...........tssst.ts..F...slplp...........tCsss...............................tss.pl...shs.................us.......sss.ss....ss.hlss......sssss.t....................................ulGlpl......................................hss.s..sss.............l.....................thssss.......................s.hshssssss..........hs......................apAphhs..............sssssss...s............GshsAssshslsYp........................................................................................................	0	59	218	557
+2529	PF04449	Fimbrial_CS1		CS1 type fimbrial major subunit	Kerrison ND	anon	DOMO:DM04212;	Family	Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia [1]. The major subunit of CS1 pili is called CooA.  Periplasmic CooA is mostly complexed with the assembly protein CooB.  In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown [1]. A member of this family has also been identified in Salmonella typhi and Salmonella enterica [2].	20.80	20.80	21.30	20.90	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.91	0.71	-4.14	13	326	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	291	4	19	128	3	139.00	45	81.62	CHANGED	VpKsITVTAsVDPTl-lLQADGSALPoulplsYhPu.pshpstplpT+IaTNDpoKslpl+LsssP.sLsNlhsPo.ppIPlsVohGGcsLoTous...olcuucL.FusuulsssSsshsLsIuts...Tsussss..AGsYQGlVSlllTQu	...................................................................VQKDITVTANlDusL-hhQsDs..o..uLP.p.sl.chpYhPG...pGL..sapL.T+l.a..SND..TK...cVphpL.luss.QL..l.p...sL.Dso.Khl..slsVThGG..cplps.suu...sh.pAspl.Fs..s..s..ths....suShs.tNLhhuQp....stusL..ps....G.YpGlVSlhlSQ..................................	0	1	9	13
+2530	PF02432	Fimbrial_K88	Fibrimal; 	Fimbrial, major and minor subunit	Mian N, Bateman A	anon	Pfam-B_2036 (release 5.4)	Family	Fimbriae (also know as pili) are polar filaments found on the bacterial surface, allowing colonisation of the host. This family consists of the minor and major fimbrial subunits.	25.00	25.00	29.00	28.90	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.57	0.70	-4.94	17	376	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	101	12	10	223	0	219.50	30	89.32	CHANGED	huG-lplsGhlTs....cshWsWplGsu.pshsssssch.spssplsIslstst..PlLhG+sh-sh.tG...GsGhsPploa.tuh-Ghsl.......shsssGpuphsLPVp.s-sssphGoLshslstuuslptspspp...................sha.GshhssshshlsGpotssssups.sht.........hhssphsshhp.....shpsuuh.s.shhocuslppltus....Yuuulstsps.chplstssss..hpWpAsLsVolsYp	........................................uGplplsGslTs...pts.WtWpVGsss.ps....h..s..schtcs............tssphslslstss...hPlLhG+sh.t.s..s..sG...tsGhsP.Isa..sspG.sh.......stsssuhhpholPVp..s-sss.ps..Gshshs.h.ptuusls.tshtsp................................a.Gs..h.hs..tsh...s...hl.s.s.p.usshstu.t.o.s.h..........hhssthsshhs.....ss.ss.u.sshs.uh..hs.D..upltplsus.....YAuslststs.-hphcts.sss...hpWpsuLsVoloYp..........................................................................	0	0	0	3
+2531	PF05182	Fip1		Fip1 motif	Wood V, Bateman A	anon	Pfam-B_4652 (release 7.7)	Motif	This short motif is about 40 amino acids in length.  In the Fip1 protein that is a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase [1]. This region of Fip1 is needed for the interaction with the Th1 subunit of the complex and for specific polyadenylation of the cleaved mRNA precursor [2].	22.70	22.70	23.70	23.80	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.69	0.72	-4.69	36	388	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	282	0	249	374	4	44.70	53	8.76	CHANGED	h-hD.l-.shc-..KPWRcPGADloDYFNYGFsEpTWctYCp+QcchRt	................-hDl-..sh..--..KPWR+P.........G...AD..lSDYFNYGFsEpTWcsYCcKQcclR.......	0	86	141	209
+2532	PF02433	FixO		Cytochrome C oxidase, mono-heme subunit/FixO	Mian N. Bateman A	anon	Pfam-B_2045 (release 5.4)	Family	The bacterial oxidase complex, fixNOPQ or cytochrome cbb3, is thought to be required for respiration in endosymbiosis. FixO is a membrane bound mono-heme constituent of the fixNOPQ complex.	24.20	24.20	24.30	24.70	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-4.98	56	1201	2012-10-03 10:02:11	2003-04-07 12:59:11	10	7	1028	0	361	915	226	199.50	49	74.82	CHANGED	HphlE+NshlLhlhshlsloIGGlVEIsPLFal-sTI.EcV......................................................-GlRPYTPLELsGR-IYlREGCYsCHSQMIRPhRDEVERY....GHYSLAAEShYDHPFQWGSKRTGPDLARVGG.KYSDpWHlsHLhsPpuVVPcSIMPuYsaLtcst.LD...........hssltschpshptl...........GVPYo..-p...............IpsApsDhpuQAssps......s.hsshhp+Y.spAthp.......saDGssttloEMDALlAYLQhLGThVD	..............................................................................................HphlE+Nshllhlhh.ll.sl.ulGGL.V.E.I.l.PLFa...cs.s.hcsl..........................................................cGh+..P.YT..s....LpL.....tGRDIYIREGChsCHSQMI..R....P....F...R...u..E.s...E.R......Y.............G.......+.......Y......Sl.A..G.Ess........Y.........D..H.........PFlW.......GSKRTGPDLAR.VG.................u.+.Y...S....D....-....WHhsHLhsP..RsV..VP-ShMPuYsaLh...csp..lD.................scss.t.tc.hpsh+.p.l...........G.V.P.Yo..--................pIspAtpt.h.....cup.........................................................................................p...........................................................................................	0	111	233	301
+2533	PF01346	FKBP_N		Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	Bateman A	anon	Pfam-B_402 (release 3.0)	Family	This family is only found at the amino terminus of Pfam:PF00254. This domain is of unknown function.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.08	121	3385	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	1650	10	537	2180	296	111.50	31	49.55	CHANGED	shuhshsssttssss...........plpopppKhSYulG.hslGpphppphhc........lDhctllpGlpDuh..tssp.tlo-E-hpps...Lpphppclptppptpht..p........ApcNtpcGctFLs-NtpK-GVhsTp.SGLQYcV	.....................................................................hts..........................shps..cppsuYulG.hp.lGpph...ppphhct...............ls.-tl.htGlpDuh.....tu.p.ps....tl...st..pp..h..pps....L..pp.hp.pchpsttptp................uptst..scGctFLpcN.tc.+......c.GVpsot..SG.LQYcV..................................	0	144	275	420
+2534	PF04620	FlaA		Flagellar filament outer layer protein Flaa	Kerrison ND	anon	DOMO:DM04570;	Family	Periplasmic flagella are the organelles of spirochete mobility, and are structurally different from the flagella of other motile bacteria. They reside inside the cell within the periplasmic space, and confer mobility in viscous gel-like media such connective tissue [1]. The flagella are composed of an outer sheath of FlaA proteins and a core filament of FlaB proteins. Each species usually has several FlaA protein species [2].	25.00	25.00	25.60	25.50	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.02	0.70	-4.93	10	195	2009-09-11 10:09:13	2003-04-07 12:59:11	7	10	102	0	60	164	0	204.90	22	55.90	CHANGED	phshsshoslDa...ucsschuasutupth....hccuLshssW.Vthsuu...sp.....tsshhtts.scsputchuus+llGVRlpFsptGpNuhull....pPsatIPhhu.....................................slKoIuVWVaGtuY.asLplLlcDppGch+phhMGpLsFsGWKpLshs.NPsalsss+sR.lp.psshYPsussclshpGF+lccDssccsG-alsYFcDl...........+llhDhhsV-hsc	........................................................................................t....................t....t.tt......h.......pa...hs.s.............................sptt.stt.h..tspplLGV+spFsphu.sshs.hh.........tsshtIshhu..................................................hh.KplsVWVaGtsatasLplhlcDhpGpp....aph.h...G.pLsFpGW+pLp......hs..sPshls.......p.p.s.Ysh.ts.lphhuFtlppsstpthssahhYhc-l...........+llhDhh......p..............................................	0	29	46	46
+2536	PF03646	FlaG		FlaG protein	Bateman A	anon	Pfam-B_2985 (release 7.0)	Family	Although important for flagella the exact function of this protein is unknown.	21.00	21.00	21.20	21.40	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.20	0.72	-3.91	139	905	2012-10-01 21:18:35	2003-04-07 12:59:11	10	1	864	1	295	725	111	111.20	22	87.37	CHANGED	ststssssstsppsspsststs..................pptppptppp......tt...sppc.lp.cslpplschhps.hpps....LpFpl--cssc.hlV+VlDppos-VIRQIPsEchLclu....cplp-..........ht...........Gl.Lhcpc	.........................................................tsts................t.tt.t.................pptt.pttptp..........pp.hspcclp.chl.c.clNchhps...hs..ps.....lpF.pl..c-.c..s..sp.hlV....pVhD.ps..Ts-lIRpIPsEEhLclh....pplp-...............hh.................Gl.lh-p.......................	1	114	218	264
+2537	PF03614	Flag1_repress		Repressor of phase-1 flagellin	Griffiths-Jones SR	anon	PRODOM	Family	\N	24.00	24.00	25.50	65.20	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.88	0.71	-4.68	3	93	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	77	0	3	55	2	147.20	63	91.53	CHANGED	DISYGREAElWPRDYSsLARRlQFLRFNDIPVRLVSsNGQlIIGYIuKFNs+ENhI.LASDcsKGsNRIEVKLEpLAoLE....ELsusDuhstoLVssDhFNlQ.hsPSRRDFFSICNKCaKQGVGIKVYMtDGRlLpGcTTGVNACQVGlppuNGNHMQVMFDWVSRI	.DIoYGh.AEhWPR-YShlt+tl.FhRhspIPVRls.psuplhshYltth.spcNhI.LASDc.sKGspRIEVKLEpLAhLE....ELsusDs....hshoLVssD.FNlQ.hsPSRRDaFSICNKCaKQGVGIKlYMt.GplLpGcTTGVNACQVGlppuNGNHMQVMFDWVSRI	0	0	2	3
+2539	PF05149	Flagellar_rod		Paraflagellar rod protein	Moxon SJ	anon	Pfam-B_6464 (release 7.7)	Family	This family consists of several eukaryotic paraflagellar rod component proteins. The eukaryotic flagellum represents one of the most complex macromolecular structures found in any organism and contains more than 250 proteins [1]. In addition to its locomotive role, the flagellum is probably involved in nutrient uptake since receptors for host low-density lipoproteins are localised on the flagellar membrane as well as on the flagellar pocket membrane [2].	21.90	21.90	22.10	27.80	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.74	0.70	-5.21	13	124	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	28	0	18	115	0	271.00	42	47.55	CHANGED	scc.lothl-s+cph+ptscpDLc+lc-phpphssscscppcpapsp+pc.-chlppNp-pQppsaccIp-LtccLpc.......LupcRpc.V-cRlcttccEcpRcssappFlphuspHpptLppolpNsctulcsssplpshVt-uCcplsuh.p-chppsLu-hhhtlpc-+LctFRshYlshGcLhaKKE+RLEpl-+pIRhsclppEhuh-oLDPNAKcaucscc-Lhtt+ppVppplshlcp+hcpu.csFcPTEcuLht....AGlcFVHPh-ElpctslpRps+lL-Y+phhs	.........................ppssthh-s++ch+ppscpDLcplp-sIQcsDh-DucshKRausp.+c+S-.chlpcN.-pQ--sWp+Ip-LERpLQc.......Lus-Rh-EV+RRIEcp-REE+R+s-.appFLclsuQHK+hLcholhNCDhAhcssuhlE-hVsEuCsslcu+.aD+sppcLusLplpV+pEaLEtFRtLYhTLGpLlYKKE+RLEElDRpIRssHlQlEhslETFDPNAKcau-tKK-LhchRtpVEcELthL+-K.spAL-.FpsoEcuL.t....AGl-FsHPh-E.pctslsRRSKhlEY+s+l...............	1	7	13	18
+2540	PF00700	Flagellin_C		Bacterial flagellin C-terminal helical region	Bateman A	anon	Pfam-B_41 (release 2.1)	Family	Flagellins polymerise to form bacterial flagella.\	\	\	    There is some similarity between this family and Pfam:PF00669, particularly the motif NRFXSXIXXL. It has been suggested that these two regions associate [2] and this is shown to be correct as structurally this family forms an extended helix that interacts with Pfam:PF00700.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.57	0.72	-3.82	33	7466	2009-01-15 18:05:59	2003-04-07 12:59:11	16	27	2537	11	1427	5887	1917	81.80	34	21.70	CHANGED	lshlspA...lsplsshpupLGssQsRlcpssssLsspps.lssuhsclccVDhsctsochsphphhhQsuhulhAphspl..slLshL	...........................ttlDsA...lspls.shRusL...GAhQN.R.l.p.ps...l.s...NLsst.......spN.l....suu.p.ScIcDsDhApEsssho+..tplLpQAutuhLu.Q.AN.phs.p...slLpLL.......................	0	485	932	1156
+2541	PF00669	Flagellin_N		Bacterial flagellin N-terminal helical region	Bateman A	anon	Pfam-B_37 (release 2.1)	Family	Flagellins polymerise to form bacterial flagella. This family includes flagellins and hook associated protein 3. Structurally this family forms an extended helix that interacts with Pfam:PF00700.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.36	0.71	-4.38	34	9093	2009-01-15 18:05:59	2003-04-07 12:59:11	15	29	2631	13	1625	7111	2324	128.50	32	35.14	CHANGED	IsTshhu.ssppslspspsplsputpclooGh+hssut-.uushuhusshpsphssLsphscssshuhuhlpsspu..Alsphtsshpp.........lppLsstuussssssh..sppshpsplppLhspls.....TsaNGphlhuGsto	.......................................................lsss..s...s.pt...l...s...psp...s...t...hsp...shp+L.S...S.GhRIss.AtDD.uu.uhulupphpsphpuLspu.tcNs.scuhuhhQosEu..u.L.s.p...h.s...s.h.LpR.........h+-..L......u...l...Q...u....u...N..u...o..t.oss......D+....su....l.p.pE....l....p....pLh.sc...l.......spl..uspTp.a.N.G.pplLsGs.........................................................................	1	534	1032	1312
+2542	PF01350	Flavi_NS4A		Flavivirus non-structural protein NS4A	Bateman A	anon	Pfam-B_211 (release 3.0)	Family	Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning regions [1].  NS4A has only been found in cells infected by Kunjin virus [2].	20.60	20.60	21.90	93.70	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.65	0.71	-4.64	32	3233	2009-09-11 15:45:06	2003-04-07 12:59:11	12	17	110	0	0	3283	0	144.70	60	4.30	CHANGED	ssllcslutlPpahtp+stpAhDshYsLhsuEtGoRAa+tAhpElPEulpTllhlshLulhThGlhhhhht++ulu+hslGhlVlssussLhWhuslssspIAGshllhalLhlVLlPEPt+QRS.pDNpLAhhllslhsllGhV	.....lsLIpElG+lPpHhsp+spsALDNLshLHTuEpGGRAYRHAlEELP-TlETLhLLuLlullTGGlhLFhhSGKGIGKholGhlClhsuShLLWMApVpspWIAuoIlLEFFLMVLLIPEPEKQRTPQDNQLAYVVIulLTllusV..	0	0	0	0
+2543	PF01349	Flavi_NS4B		Flavivirus non-structural protein NS4B	Bateman A	anon	Pfam-B_211 (release 3.0)	Family	Flaviviruses encode a single polyprotein.\	     This is cleaved into three structural and seven non-structural proteins. The NS4B protein is small and poorly conserved among the Flaviviruses. NS4B contains multiple hydrophobic potential membrane spanning regions [1].  NS4B may form membrane components of the viral replication complex and could be involved in membrane localisation of NS3 and Pfam:PF00972 [1].	25.00	25.00	81.70	81.20	18.10	17.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.49	0.70	-5.45	35	3305	2009-01-15 18:05:59	2003-04-07 12:59:11	12	19	110	0	0	3287	0	244.40	64	7.42	CHANGED	NEMGaLE+TKpDlttlFht.ppp...ptpssshp......slDL+PAouWuhYushsolhTPhlhHhlpophtshuhuuluupAssLhsLspGhPFhslchsVshLslushsphTssoLhsulsLsshHauhllPGhpAphs+pAp+pshuGlhKNssVDG.lssDlsch-stsshhEKKlu.llLlsLslsulllsRsshuhtEAusLsoAAlspLh-ssssshWshssAsGhsslh.RGsahuslsl...sWshhpssc	....NEMGhLEpTK+DLG..hGphtt....pp.s.p.u.....h..LDlDL+PASAWTLYAVATTllTPMLRHoIENoosNlSLTAIANQAslLMGLsKGWPlSKMDlGVPLLAlGCYSQVNPlTLTAAlLLLlsHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIssIDL-Pls.YDsKFEKQLGQlMLLlLCssQlLlMRToWALCEAlTLATGPloTLWEGuPG+FWNTTIAVSMANIF.RGSYLAGAGLhFSlMp......p.........	0	0	0	0
+2544	PF00972	Flavi_NS5		Flavivirus RNA-directed RNA polymerase	Finn RD, Bateman A	anon	Pfam-B_200 (release 3.0)	Family	Flaviviruses produce a polyprotein from the ssRNA genome. This protein is also known as NS5. This RNA-directed RNA polymerase possesses a number of short regions and motifs homologous to other RNA-directed RNA polymerases [2].	19.00	19.00	19.00	19.10	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	649	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-13.14	0.70	-6.64	7	5252	2012-10-02 12:54:00	2003-04-07 12:59:11	15	19	173	49	1	4283	0	449.30	66	21.01	CHANGED	Th.sDlsLssGTRuVsttpsh..shptltcRlp+L+pEapsTWahDp-HPYRTWpYaGSY.scsoGSAuShVNGVVKLLohPWDsltpVTpMAMTDTTPFGQQRVFKEKVDT+s.-P.tGTRclh+ssspWLachLu.+cKpPRlCT+EEFIsKVRSsAAlGAhhpEpptWpoApEAVpDs+FW-LVDcERphHLpG+CcoClYNMMGKREKK.uEFG+AKGSRAIWYMWLGARFLEFEALGFLNEDHWhSRENShuGVEG.GLphLGYlL+-lup+pGGhhYADDTAGWDTRITcsDL-sEphlhphM..sscH+tLApAlhcLTYpNKVVKV.RPsscGt..slMDVISRRDQRGSGQVVTYuLNThTNhcVQLlRhhEuEGVIptpchpp.....hhtlptWLpcpGp-RLpRMAlSGDDCVV+PlD-RFusALpaLNsMuKsRKDIspWcPS+GWssWppVPFCSHHFHElhhKDGRslVVPCRsQDELIGRARlS.GsGWsl+ETACLuKAYAQMWsLhYFHRRDLRLhu.AIsSAVPscWVPTGRTTWSIHuptEWMTTEDMLcVWNRVWIp-NPaMpDKTslpuWcDlPYLsK+pDhhCGSLIGhppRATWAcsIhsulppVRplIGpEc.....YsDYhssMcRYpttt-.t	..................................................hE.DVsLGuGTRtlsh.....ss.phItpRIppl+pEat..poWHhDpppPY+TWsYHGSY-s+.oGSASShlNGVV+LLoKPW.Dsls.VTphAMTDTTPFGQQRVFKEKVDT+s.cs..Gst.lhp.TspWLWt..Lu.+pKpPRhCo+EEFhpKVpoNAAhGAhF.-pNpWpoA+tAV-D.cFWchVccERphHh.GcCtoClYNMMGKREKK.GEFGKAKGSRAIWaMWLGARaLEFEALGFhNEDHWhuRcN.ShuGVEG.G..Lp....+L.GYILR-..luph....GGthYADDTAGWDT.RIT.tDLpNEth.lh.p.h..csEHt.LApuIhcL.TYppKVV+V.RPs.pG...TVMDlISRcDQRGSGQ.VsTYuLNT.F.TNhtsQLlR.MEuEGlht...ph.p......t.tl.pWL.p.G.ERLpRMAlSGDDC..VV...KPlDD.RFA.s.uLhhLNsMuKlRKDI..pWpPSpGW.sWppVPFCSpHFppLlMKDGR.lVVPCRsQDELlGR..ARlS.GA.GWsl+-TACLuKuYAQMW.LhYFHRRDLRLhusAICSAVPspWlPTuRTT.WSIHuttpWMTTE.DMLpVWNRVWIp-NPWM..EDKT.VpsWp-lPYlGKRED.WCGSLIGhpuRATWApNI.sAIpQVRtlIG.p.E.p.....YhDY.MsSh+Racpp..........................	1	0	1	1
+2545	PF01570	Flavi_propep		Flavivirus polyprotein propeptide	Bashton M, Bateman A	anon	Pfam-B_304 (release 4.1)	Family	The flaviviruses are small enveloped animal viruses containing a single positive strand genomic RNA [1].  The genome encodes one large ORF a polyprotein which undergos proteolytic processing into mature viral  peptide chains. This family consists of a propeptide region of approximately 90 amino acid length.	27.60	27.60	28.20	28.30	25.60	27.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.42	0.72	-4.26	9	5590	2009-09-11 10:42:09	2003-04-07 12:59:11	12	23	116	2	0	4419	0	80.40	58	3.84	CHANGED	s+pG-shMllstp-+sculhh+sssG.NhCslhAhDlGchC-DTlTYcCPplsp.sEP-DlDCWCssss.saVpYGpCspsucpRRp+	.........o.RsGEPpMIVsppE+G+uLLFK.TusGlNhCTLhAMDLGEhC-DTlTYcCPhlsp.sEPEDlDCWCstos.saVpYGpCo.p..sucpRRp+...........	0	0	0	0
+2546	PF02525	Flavodoxin_2	NADHdh_2; 	Flavodoxin-like fold	Bashton M, Bateman A	anon	Pfam-B_1456 (release 5.4)	Domain	This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2.  These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species [1].\	    This enzyme uses a FAD co-factor.  The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy [1]. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP [2]. This family is related to Pfam:PF03358 and Pfam:PF00258.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.50	0.71	-4.81	247	7847	2012-10-03 05:08:30	2003-04-07 12:59:11	12	15	2899	188	1533	11821	2314	183.60	23	92.92	CHANGED	h.+lLll.ups.........ph.t.......uhspplspthhpthpptt......p....Vph.pDLhp......s.ht....................................................s.tp...t.hss....tt-p..pplhtADhllhthPha.auhPuhLKsalDpVhptGh.....sa.........t......tsLh.....GK.cshlhsop.Gus.hsht........t.sh-thh...hcshh.tahGhpsl....phhh...hpsht......s.pt.ppthppshp....phtp.l	........................................................................................................................plLllhups..........p.............p.s...s....t.ls....c.t...h....h....c..t....hpptt.............pp....................Vp.h...hD.....Lht...........................................................................t..p...........hsh.......tt-p....pp.lh....t.ADh..llhthPha.h...auhPshLK.t...alD..c...V....h...p..t..Gh.........sa..................t..u......s....t.sh.Lp.....GK...+.h.hl.h.hot....Gu.s...ptht.....................tt.sh..-.h.h..h....hc.t.h.h..t.a.hGhp.....l......tshh........hp.sht.......p...tpthtp.hhtth....h................................................................................................	0	410	843	1194
+2547	PF02441	Flavoprotein		Flavoprotein	Bateman A	anon	Pfam-B_1622 (release 5.4)	Family	This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD Swiss:P30197, which has been shown to be a flavoprotein that binds FMN [1]. This enzyme catalyses the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance [2]. dipicolinate synthase catalyses the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase Swiss:P33751 (EC:4.1.1.-) [3].	22.20	22.20	22.20	22.20	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.76	0.71	-4.47	143	8070	2009-01-15 18:05:59	2003-04-07 12:59:11	14	27	4696	49	2213	5827	2565	130.60	29	43.39	CHANGED	t+lllulTGusushh.uhcllctLt...cp...............hc..lp.llhopsA.pphlp.ts...............................thhpp..............................................lhsp............................tpshhspls..up...sDhhllsPsossTluKlAsGluDs.Llsps....................shst.h..........p+s.l..l.lsPshssh.....sshs	...................................................................................+llluloG.u.hu.Ahc..uscLlptLp...ct.........................................u......h-....V+.llhop...uA...pphlss.oh.................................tshstpt.....................................................................................................................................lhs-..............t..............................ssps...h..s..+.I.........s.......h...up..h.........sDhhllAP.sousolA+lApGhuDs..Llops..................................................shs..s..............................ppP..ll.lsPu.hsshhh.p.h...................................	0	675	1384	1855
+2548	PF00460	Flg_bb_rod	flg_bb_rod; 	Flagella basal body rod protein	Finn RD	anon	Prosite	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.77	0.72	-7.27	0.72	-4.19	16	12885	2009-01-15 18:05:59	2003-04-07 12:59:11	15	19	2264	1	2918	8471	1594	30.40	34	10.36	CHANGED	lhsuhouLsspppplcllusNlANss.TsGaK	..............h.huhoGhs..up.ppphsllusNlANs....s.TsGap..........	0	910	1827	2357
+2549	PF02120	Flg_hook		Flagellar hook-length control protein FliK	Mian N, Bateman A	anon	IPR001635	Domain	This is the C terminal domain of FliK. FliK controls the length of the flagellar hook by directly measuring the hook length as a molecular ruler [1].  This family also includes YscP of the Yersinia type III secretion system, and equivalent proteins in other pathogenic bacterial type III secretion systems.	29.80	29.80	29.80	29.90	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.28	0.72	-4.31	344	2733	2012-10-01 19:58:36	2003-04-07 12:59:11	11	7	2004	1	679	2315	298	85.60	22	18.28	CHANGED	tpphthtt.spshpphplpLsPscLGplplpl...phpss..p....lplpltsppspstphLcpshspL+ptLpp.......tGlpls.p..hsl..sttsttpt.t	......................tt.......hppstppsplcLcPtcLGplplpl...phsss..p.....h.plphhuppppspptLcpshspL+ppLsp.....pGlpls..p....hsl....stps.t...pt.............................	0	209	424	550
+2551	PF03963	FlgD		Flagellar hook capping protein - N-terminal region	Bateman A	anon	COG1843	Family	FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum [1]. It appears to act as a hook-capping protein to enable assembly of hook protein subunits [1].  FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerisation and also plays a role in determination of the correct hook length, with the help of the FliK protein [2].  This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallisation [3].	21.20	21.20	27.30	27.10	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.82	0.72	-3.91	135	2310	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	2042	0	554	1527	340	81.20	32	36.84	CHANGED	sssssss....ssssssstst.........................s.sssssss.......hspc..s.FLpLLlsQLpNQDPhsPhDsscasuQLAQFSslEthpphNsslpsl	................................................................................sshss..............tst.t.t.t................................stssssss...hsps..s.FLpLLlsQLpNQDPhs..P..h-s.......schhuQhAQhSsVp.thpphNsslps............	0	176	346	446
+2552	PF02107	FlgH		Flagellar L-ring protein	Mian N, Bateman A	anon	IPR000527	Family	\N	20.40	20.40	26.50	21.40	19.60	19.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.87	0.71	-4.71	159	1866	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	1593	0	422	1225	436	186.10	37	80.12	CHANGED	ts.stsss...GSla..psup..........ssLa..................pDpRAt.....plGDIlTVhlpEs.spAopsusosts+....sushsh....sh..sshh..................uhstts....................t..hshsu.sss...asGsGss..spsssLsuolossVscVLPNGNLhIpGcKplplNptschlploGlVRPcDIs......ssNolsSs+lA-ARIpYuGpGtls-spp.GWLp+hass.lhP	...........................ss....sssGSlapsup........psLF..................p.D.+Rsp.....plGDllTlllpEs..ss.ASKsussstuRsusssh....uh...ssls................shststs.....................s..hpssu.sss...Fs..GpGuu..spuNohsG..olTVsVspV.Ls.N.GNLhlpGEK.p.lt..lNpG..sEhI.RlSGlVcPcDIu.........ssNTVsSsplAD..ARIpYsGpGhl....s.-.u.Q.p.h.G.WLpRaF.s.l.P...................	0	107	239	330
+2553	PF02119	FlgI		Flagellar P-ring protein	Mian N, Bateman A	anon	IPR001782	Family	\N	25.30	25.30	25.40	26.90	25.00	24.80	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.01	0.70	-5.80	159	1904	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1613	0	429	1324	595	332.20	48	91.94	CHANGED	RIKDluslpGVRsNQLlGYGLVVGLsGTGDp....ps.sFTpQSlpsMLpphG..........l.sl...s.............ss............h.cs..KNVAAVhVTApLPsF.u+sGpplDVTVSSlG-AKSLcGGTLLhTPL+Gu...DGplYAlAQGslllGGhuup..Gts....uplphNhPTsGRIPsGAhVERpl......ss.sh.spt.sslpLsLcpsDFo..TApRlscuIN....pth................Gsss......ApulDusolpl..phPts.p.p..tVsFluplEsLpV.....ps.cssA+VVlNpRTGTlVhGpsV+ls.ssAVoHGsLTVpIs-s..tV...SQPs.sh..........u...............tGpTslsspoplslppp.....ssphhhl..ts.usoLs-lVcALNslGssPpDlluILpAlKsAGALpAEL.ll	.............................................................RI+DlsslpGVRpNpLlGYGLVVGLs.GTGDp....spo...PFTpQolsNMLpphG..........I..sl..Ps.......tss..................h..phKNVAAVMVTAsLPPF.u+tGQpIDVsVS..S..h...Gs..A..KSLRGGTLLhTPL..+Gs................DGpV.....YAl...AQGsllVGGh..uAp..........usu...SplpsNp.suGRIssGAhlEREl......................Ps.sF..ups...sslsL..pL..p..c..sDFo..sApplscsIN....phh........................G.ss..........ApAlDupolpVpsPpsss....s.............pVpFLAplpslpV.....ss..tstsAKVllNuRTGoVVhsppVplp.ssAVup...GsLoVslscp...p.V...SQPs.PF.....u......................sGpTsVsPpopIs.lppp.....suplh.l...ps.usoLsslV+ALNslGAoPtDLhuILQuh+pAGALcAcLplI......................................	0	119	250	339
+2554	PF04316	FlgM		Anti-sigma-28 factor, FlgM	Kerrison ND, Finn RD	anon	COG2747	Family	FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis.  Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28.  All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium (Swiss:P26477).  The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery [1].	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.51	0.72	-4.03	135	1810	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1600	5	419	1076	250	64.00	28	67.14	CHANGED	DsVplSspuppl.pphptt.......................h..sstsslcpp.KVpplKpAIssGsYplDscclAcpllpht	....................................................................t.tVplSsttt...p.............................................h...ssss.-lsh-.+V..ptlKpAIps.GphplD..s..p+lAcsllp..h...............	1	135	267	349
+2555	PF05130	FlgN		FlgN protein	Bateman A	anon	COG3418	Family	This family includes the FlgN protein and export chaperone involved in flagellar synthesis [1].	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.80	0.71	-3.94	154	1850	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1595	3	413	1145	136	134.40	23	91.77	CHANGED	M..................ppLhphLp..pphphhpp....LhpllppEppsLtst..c.hp.tLpplspp...Kppllpplpphc..ppptphhtphsht....................h..........ppspltphhpp....lpphhp...chpphNphNspLlppphptspphlshlpsspst.......tsYsssGptps	...................................ptLhphlpp..shlpp....LtslhcpEpptLpts.....s.ss..pLptlscp...KspLlspLsth-....ppRp...ph.pphs.........................................................tpspltpthpp...............lpphhp....pl+phNppNu...hLlptphchspp.hlphlpstpps.......shYsspGp................................................	0	137	261	336
+2556	PF02465	FliD_N		Flagellar hook-associated protein 2 N-terminus	Mian N, Bateman A, Yeats C	anon	Yeats C	Family	The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria [2]. This alignment covers the N-terminal region of this family of proteins.	22.70	22.70	22.70	23.80	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.99	0.72	-3.63	191	2117	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	1839	0	481	1599	330	99.40	27	18.77	CHANGED	uSGlD..hssllspLhs.uEptsh...splppppsphpsploAauplpotLsshp.......s.shssL......tp.......s..s..sa.........ps..............pss...osS..ss.......shlos........ousus..As..sGoYsl.pVppLApupp	......................SulDhssllspLhp..A-ctsh....s....lspppsshsschoAa.usLcosLsshp........s.uhssL......sp..............s.....s......sa...............ss..............pps.......ooS....ss...........ss.h.os........o..s.s..us..Ah..sG..s.Y..sl.sVsQLApupp.....................................................................	0	160	302	395
+2557	PF02049	FliE		Flagellar hook-basal body complex protein FliE	Mian N, Bateman A	anon	IPR001624	Family	\N	22.40	22.40	23.10	22.90	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.97	0.72	-3.96	186	2295	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	2048	0	548	1400	351	98.30	29	92.64	CHANGED	tsh.............t..tssssssssssssssssssFushLppulspVsptQp...pusphspshtpG.c.ssslp-VMlAhp+AsluhphslpVRNKllpAYpEIMpMtl	..............................thhpshh..........t.sstspsssspsssuFushLpsu...l...s...cl...sppQp...sAcsts.pphthGc..sssLp-VMlshpKAslohphslpVRNKlVpAYpElMpMpl....	0	175	345	444
+2558	PF01706	FliG_C	FliG-C; 	FliG C-terminal domain	Bateman A	anon	[1]	Domain	FliG is a component of the flageller rotor, present in about 25 copies per flagellum.  This domain functions specifically in motor rotation.	23.00	23.00	23.30	23.80	22.20	22.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.03	0.72	-4.08	154	2393	2012-10-02 13:19:07	2003-04-07 12:59:11	11	8	2047	8	574	1470	494	109.70	39	32.55	CHANGED	lpslc.ppDsclApcI+cpMFsF-cl.hclcscslpplL+pls.scs...LslALKGAspp........lc-plhsNMSpRuuchlc--hcthGsV.+ls-VEpAQppIlphlRcLs-pGcI.ls	..................................pslc.chDs-LApcIp-pMFlFEsL.lc...lDD+uIQclLcEVs.s-s...LhlALKGAspt........L+-KhhpNM..SpRAA-..hlc--l.p.s.h.G..P.V.Rls-VEsAQ+pIltllR+Lu-sGEIhl.u.............	0	199	374	466
+2559	PF02108	FliH		Flagellar assembly protein FliH	Mian N, Bateman A	anon	IPR000563	Family	\N	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.18	0.71	-4.26	50	2270	2012-10-02 21:03:42	2003-04-07 12:59:11	11	6	1901	0	508	1633	260	133.70	22	54.20	CHANGED	ppt.hpplps....lhpplppslpph.......-pp....lpppLlpLslplu+pllt.pclpssPphllshlccsL.tthPhsspplplplpPsDhshlcpths.pthpthta.....plhsDsslspGGCplpossuplD.......uslpsRhcpl	.................................................................................................p....tphpt.lhsphppsh.pth...........ppp...........hppcLh.phulp.h....A....+pVlt..p....ph..p...s......s.s.p.t.l......l.p...h.l.p.psL...t...p..sh.....t....s......splpl+V...p....P....-.D....hp....hl...c...c....t...hs....t.....h.p...h...psa...................cl.hsD..ssL.....p........GuChlps-pGp.lD.......uslpsRhpp..........................	0	169	313	407
+2560	PF02050	FliJ		Flagellar FliJ protein	Mian N, Bateman A	anon	IPR000809	Family	\N	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.52	0.71	-4.07	147	1890	2012-10-01 21:16:01	2003-04-07 12:59:11	11	4	1724	1	454	1152	113	121.90	22	82.41	CHANGED	-cutppLsp...sppphpptppplptLpp.tppa..tpthpsph.......sphpphppalsplcpsItppppplpthcpplpptpppapptptchcphchLhp+ctpppppt.p+pEQ+hhDEhAhpta	.......................................................-pAtptLup...hp..pthpp....t....p....pp....Lp..Lhp....hpp....-a....ppphs....s.......sh...t..G.....h.....ss.....sphhs..hpp..Flp.......sLc.psIsppcp....plpphppcl.......-pspppapctppchpshppLp-+pppptthtps+t-QKthDEhAtpt.................	0	149	289	371
+2561	PF03748	FliL		Flagellar basal body-associated protein FliL	Bateman A	anon	COG1580	Family	This FliL protein controls the rotational direction of the flagella during chemotaxis [1]. FliL is a cytoplasmic membrane protein associated with the basal body [2].	23.80	23.80	23.80	23.90	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.16	0.72	-4.00	175	2462	2009-09-10 21:49:05	2003-04-07 12:59:11	9	6	1859	0	634	1614	444	101.40	24	62.20	CHANGED	shahsl....s...shslNlsss.....tt..+alp.lplslps....pspps.....hpplcp.....phP..h.lRssllthluspshp.....-lpss.pGpppL+pclhcpls.hl.............hpsp...............................lpsVhFosFllQ	.....................................ahsL....c...shslNLsss.....ttp..+hlp.lslsLpl..........pspts.........tsplpp.................thP........lRspllhhhup.....ps.h.p.....pLps..pG+.ppL+pclppplsphL.............stsp............................................lpcVLaTsFll.....................................	0	199	394	512
+2562	PF02154	FliM		Flagellar motor switch protein FliM	Mian N, Bateman A	anon	IPR001689	Family	\N	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.01	0.71	-4.64	7	1999	2012-10-01 19:50:22	2003-04-07 12:59:11	10	2	1927	3	493	1477	440	191.20	37	56.93	CHANGED	YDFppss+hS+EplpoLphla-pFARhhoouLpshLRphlclplsuVcphsYtEFlpSlPsPTsLslhphcPLcGsullplsPolsFshlDpLhGGcGpshs...csR-hTcIEppllppllchlLtsh+EAWpslhslcschschEsNPpFspIVs.PsEhllllsLclclGchpGhhNlClPahslEPIhphL	.............................................................YDhpp.cRls+-+.lpsL-hIpE+FARphphsLhshlRp.ss-lslsulc.hs.Y.p.EF.h.c......sLP.s.P.T.s.L...N....l....l..c......h.....c.....P.....L...+.....G...o.....u.....L.l.hhsPsLlFhhlDsLaG.G.cG.+......h........st.......-uRE..F..T.p.h.E....pc....l....lp....p....lLclsh....p....s....hp-AW....p.......s.l....h..s.....l...c.s....c...a.h..c.....s....E..h......s.s..p....a.....ss....I..so...Ps-.l.Vlh.ss.aclcl.G.s.h.s.GphsI.ClPashlEPlp-hL.................................................................	1	173	321	407
+2563	PF04347	FliO		Flagellar biosynthesis protein, FliO	Mifsud W	anon	COG3190	Family	FliO is an essential component of the flagellum-specific protein export apparatus [1]. It is an integral membrane protein. Its precise molecular function is unknown.	21.10	21.10	21.10	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.88	0.72	-3.94	108	1689	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1647	0	458	1182	140	88.50	26	54.79	CHANGED	AWLl+Rh......t....s..sss.tssstl+llushslGs+E+lllVcVssp.....llLGVTspplshLcp....l......................Pssssts.st.s...............................FuptLpphhpp	....................sWll+.Rh...............t...sstt..ssspsL+lluutuLGs+c+lllV..c.Vscp.....pllLG.VTs.s.pIslLcp.....L....................P.ps.tt.t.st............................................Ftphhpphh..........................................................................	0	155	289	373
+2564	PF00813	FliP		FliP family	Bateman A	anon	Pfam-B_1679 (release 2.1)	Family	\N	23.70	23.70	24.40	24.10	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.27	0.71	-4.60	141	3505	2009-01-15 18:05:59	2003-04-07 12:59:11	15	4	2195	0	652	2050	491	188.20	45	81.00	CHANGED	llTlLoLhPulllhhTSFTRIllVLulLRpALGhQQsPPNplLlGLALFLThFlMsPVhpphhpsuh.........pPhhstpl.....................shppAhpputtPh+pFMhcpT....cpp....-LthF.....hclu..........ptt.....sp.....shc-ss......hhlLlP..............AFhlSEL+sAFpIGFllalPFLlIDLVVASlLMuMGMMMlsPshISLPFKLlLFVLlDGWsLlltuLl	.................lThLollPslllhhTSFs+lllVhulLRsALGhQpsPPN.lLhGlALhLThFlMsPVhpclhppuh.....pP..h..h..ptpl.....................ohppAhc.c..utpPh+pFMl+pT....ccp.....-lthF.hclu..........................ptt...............p..s.csss...hhlLlP..............AFslSELKoAFpIGFhlalPFLlIDLVVuSlLMAhGMMMlsPshISLPFKLlLFVLlDGWsLlltuL..............................	0	200	389	513
+2565	PF02561	FliS		Flagellar protein FliS	Mian N, Bateman A	anon	COGs	Family	FliS is coded for by the FliD operon and is transcribed in conjunction with FliD and FliT, however this protein has no known function.	22.80	22.80	22.90	22.80	22.20	22.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.40	0.71	-4.26	6	2094	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1843	11	478	1234	391	123.60	32	91.09	CHANGED	hps.shpAYpQs....pVpTAoPtcLllMLY-cuIppLppAtc.....shpspchc+tscpI.+Ap-IIo.ELpsoLDhEpGtclupNLhulYsahh+pLhpANlcp-ssclspVhshh+sLp-AW+clhps.	............................................hs....uhpsYt....ps.......pl....h....s....A....SPppLlhMLa-GslptltpA+h........thp.pps.....htt+sttlsKAhsIlp.tLpssL-h..E....p..G.....u.....Elu..psL...tuLYsahh.pc..L..h..p..A.N..l....c..s.D...s...p.tl-EV..sllpslt-AWcph.....................................	0	163	309	394
+2566	PF01698	FLO_LFY		Floricaula / Leafy protein	Bashton M, Bateman A	anon	Pfam-B_1633 (release 4.1)	Family	This family consists of various plant development proteins which are homologues of floricaula (FLO)  and Leafy (LFY) proteins which are floral meristem identity proteins. Mutations in the sequences of these proteins affect  flower and leaf development.	20.20	20.20	20.20	20.70	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.53	0.70	-5.61	38	1844	2009-09-13 17:08:47	2003-04-07 12:59:11	11	5	1128	2	26	1110	0	134.20	55	97.00	CHANGED	MDP-s.F.....oAu.......hFK.WD....P+ssh.........s.Ps.....spl..pths.s.......sP...............s.ssht..hR...................uLE-LFpuYGVRYhTsAKIuELGFTssTLlsM+-EELDDMMsoLuclFRWDLLVGERYGIKAAVRAERRRL--...................................-..s+R+t..............ssDsss..sLDALSQE....G.LSEEsstp...h..uuuS..........................GGsu.sshthhshs......pc.........c++t....+p+++ptcc............................t.p..t.tttstts..........uGssGt....ERQREHPFIVTEPGEVARGKKNGLDYLFHLYEQCRcFLlQVQsIAKERGEKCPTKVTNQVFRYA.KKsGASYINKPKMRHYVHCYALHCLDEEuSNsLRRuaK.ERGENVGAWRQACYpPLVslAucpGWDIDulFNuHPRLuIWYVPTKLRQLCHhERussss	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FcLYEQCtcFL.pV.QplAKE+GEKCPTK.......VTNpVFRaA.KhsGA...............................................................................................................................................................	0	11	21	24
+2567	PF00624	Flocculin		Flocculin repeat	Bateman A	anon	Pfam-B_51 (release 2.1)	Repeat	This short repeat is rich in serine and threonine residues.	20.80	20.80	21.60	20.80	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.32	0.72	-4.12	173	1092	2009-01-15 18:05:59	2003-04-07 12:59:11	13	66	28	0	906	1281	2	43.60	44	27.58	CHANGED	tsso.Toho.sWos.shooTaSThhsThoss-G..pTTcTIYaVtTPh	...........h..to.Toho...sWTG.oh.ToThSTph.TThTGo-G....sT...sETlYhVcTPh.....	0	41	549	884
+2569	PF05202	Flp_C		Recombinase Flp protein	Studholme DJ, Finn RD	anon	DOMO:DM01865;	Family	\N	25.00	25.00	63.30	62.60	24.40	18.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.57	0.70	-5.16	8	18	2012-10-02 14:09:14	2003-04-07 12:59:11	7	2	15	12	3	31	0	194.40	52	58.85	CHANGED	uspluccloKllcs-.csIWpllsplhsoI-ppoppsop+AtYpalLlsTFhNCCRtSDLKNsDPpTFEllpN+aLG+llRAhVsETKTRpsRaIYFFPlp.G+sDPLlALa-aLppspPl.K..oRTScpcoc.Q-aQLLRDoLlpsYDRFluKcuspulFuIhpGPKSHLGRHLMuSYLSpsphschsosaGNWSAuccphpSsVARu+YsHs.ppslPscLFAFLSsYYtcsspGch......cLhssp	.h...s.th.+hh..p...hathh..hhp.hp..sh.sphps.hphhh.hohhNCsR.sDlKNhDPpoFcll.spaLGhhlpshVs-TKTph.RalYFassp.sthDPllhLcphhp.spPh.K..shossppsp.QcaQLL+-sLltsYs+hltKpss.ulFuIhpGPKSHlGRHLMsSaLSh+sLsELssllGNWS...DctuSuVARosYoHp.hsuIPDHhFAhlScYYshsP.uKphlsh..KDcs.P........	0	2	2	2
+2570	PF04964	Flp_Fap		Flp/Fap pilin component	Bateman A	anon	COG3847	Family	\N	23.90	23.90	23.90	23.90	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.16	0.72	-4.36	26	1017	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	521	0	401	913	41	46.60	34	72.55	CHANGED	Fh+-E.sGATAIEYGLIAuhIAlsll..ssssslu..ssLpstFsplusul	...........FhcDE.pGsTAIEY.GL.IAul.lAlsl..l......susss.lG....ssl.s.shF.sslsst................	0	120	223	315
+2571	PF03930	Flp_N	Flp;	Recombinase Flp protein N-terminus	Finn RD, Studholme, DJ	anon	DOMO:DM01865;	Domain	\N	25.00	25.00	25.20	42.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.67	0.72	-4.22	7	12	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	10	12	1	23	0	80.70	32	19.65	CHANGED	hss.....cchstlKhoTFhKYpppIppolpaDhsspsVpFcYHLKcsp-LpcsLccshtPhpFpl...pupKKssshhplhuuhc.+hp	............cpsstlKhuTFhKYpphIupoLpaDhsspslpFcYHhpcspcLpcsLcphhtshpFsl...tsp++.ssh.phhuuhphp................	0	1	1	1
+2572	PF02662	FlpD		Methyl-viologen-reducing hydrogenase, delta subunit	Bashton M, Bateman A	anon	COG1908	Family	This family consist of methyl-viologen-reducing hydrogenase, delta subunit / heterodisulphide reductase.  No specific functions have been assigned to this  subunit.  The aligned region corresponds to almost the entire delta chain sequence and contains 4 conserved cysteine residues.  However, in  two Archaeoglobus sequences this region corresponds to only the C-terminus of these proteins Swiss:O29030 and Swiss:029595.	22.30	22.30	22.90	23.90	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.23	0.71	-4.43	66	475	2009-09-12 00:14:48	2003-04-07 12:59:11	11	77	203	0	303	485	67	116.80	37	34.02	CHANGED	+IluFsCsasuYuuA..DhAG......ssRhpYPsslRlI+VhCoG+lsstallcAhpcG.ADGVhVsGC+hGD...CHah.pGNhpAccRhphl+chLpplGl-s-RlchtalSuuEup+asphlp-hscclccLG	.........................+IluFhCpasuYsu.A..DhAG......ssRhpYPss.lRlIRV.CoG+lsshallcAhpp..G.ADGVhlsGC+..G-...CHah.pGNh.........h...up+RhthlpphLpplGl-s-RlchpalSuuEut+asphlpchscplcpLG...................................	0	150	250	287
+2573	PF02947	Flt3_lig	flt3_lig; 	flt3 ligand 	Griffiths-Jones SR	anon	Structural domain	Domain	The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.	25.00	25.00	36.60	29.60	17.80	16.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.84	0.71	-4.27	3	56	2012-10-02 01:28:15	2003-04-07 12:59:11	9	3	25	12	16	72	0	110.10	67	52.30	CHANGED	TPDCYFSHSPISSNFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKALWSLFLAQRWIEQLKTVAGSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHLLKDTCTQLLALKPCIGKACQNFSRCLEVQCQ	....sC.F.aSPI.SSsFt.phtpL...............SDYLLQD.YPVTVAoNLQD-cLCGAhW+LVLAQRWMtRLKTVAGScMptLLEtVNTEIHFVTpCAFQ.s.PsCLRFVQsNIS+LLQ-TspQLhALKPhIs+.......pNFSpCLELQCQ................	0	1	1	4
+2574	PF04772	Flu_B_M2		Influenza B matrix protein 2 (BM2)	Kerrison ND	anon	Pfam-B_2165 (release 7.6)	Family	M2 is synthesised in the late phase of infection and incorporated into the virion.  It may be phosphorylated in vivo.  The function of BM2 is unknown [1].	25.00	25.00	147.40	147.30	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.42	0.72	-4.00	4	501	2009-09-11 00:30:47	2003-04-07 12:59:11	7	1	487	16	0	121	0	108.60	95	99.99	CHANGED	MLEPFQILSICSFILSALHFMAWTIGHLsQIKRGVNhKIRI+sPNKETINREVSILRHsYQKEIQAKETMKElLSDNMEVLSDHIVIEGLSAEEIIKMGETVLEVEELp	MLEPFQILSICSFILSALHFMAWTIGHLNQIKRGVNMKIRIKGPNKETINREVSILRHSYQKEIQAKETMKEVLSDNMEVLSDHIlIEGLSAEEIIKMGETVLElEELH..	0	0	0	0
+2575	PF02942	Flu_B_NS1		Influenza B non-structural protein (NS1)	Bateman A	anon	Pfam-B_198 (Release 6.4)	Family	A specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 Swiss:Q64339 to its target proteins both in vitro and in infected cells. Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most predominant. Influenza A virus employs a different strategy: its NS1 protein does not bind the ISG15 protein, but little or no ISG15 protein is produced during infection [1].	25.00	25.00	246.10	245.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.67	0.70	-5.47	5	839	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	785	7	0	395	0	243.30	96	87.75	CHANGED	MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPEuKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYClKNPSNSNCPNCsWADYPPTPGKYLDDIEEEPENVDDPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERF	...MAsNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKSSSNSNCsKYNWTDYPSTPGRCLDDIEE.EPEDVDGPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDMRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERL........	0	0	0	0
+2576	PF03506	Flu_C_NS1		Influenza C non-structural protein (NS1)	Bateman A	anon	Pfam-B_980 (release 7.0)	Family	The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment  encodes a 286 amino acid  non-structural protein NS1 [2]. This protein contains 6 conserved cysteines that may be functionally important, perhaps binding to a metal ion.	25.00	25.00	114.50	114.10	18.70	18.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.02	0.71	-4.50	2	111	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	80	0	0	66	0	146.10	98	64.31	CHANGED	GELLFNGTILQAESsTMT.ASVEMKGKK.PIDFsPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIA+QVAGIETGIRKCFRCIKSGFVMATDEISLhILpSIKSGAQLDPYW	GELLFNGTILQAESPTMTPASVEMKGKKhPIDFAPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIARQVAGIETGIRKCFRCIKSGFVMATDEISLTILRSIKSGAQLDPYW	0	0	0	0
+2577	PF03555	Flu_C_NS2		Influenza C non-structural protein (NS2)	Bateman A	anon	Pfam-B_346 (release 7.0)	Family	The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment  encodes a 286 amino acid  non-structural protein NS1 Pfam:PF03506 as well as the NS2 protein. The NS2 protein is only about 60 amino acids in length and of unknown function.	25.00	25.00	133.60	133.10	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.00	0.72	-4.05	2	203	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	80	0	0	112	0	56.80	99	27.82	CHANGED	VKSTNLMAFVATKMLERQEDLDTCTEMQlEKMKsSTKARL+TESSFAPRTWEDAIKD	VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKD.	0	0	0	0
+2578	PF00598	Flu_M1		Influenza Matrix protein (M1)	Bateman A	anon	Bateman A	Domain	This protein forms a continuous shell on the inner side of the lipid bilayer, but its function is unclear.	20.90	20.90	21.10	23.00	20.20	18.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.86	0.71	-4.83	2	22622	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	22201	27	0	3071	0	152.20	94	61.75	CHANGED	SLhs-s.sYlLSlh.sG.hKAElAp+LcshFuGKphDL-uhhEWlKs+.hLoslpKullGhshshhhPp-p..p+RRFlppsLsG.Gssss.hcthlhh.RKh+RploFHtAhEIA.uapuuALh.ChhlhY.phGshohpVhLGhlCAhCEp.Asp	..........SLLTEVETYVLSIlPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNN.MDRAVKLYRKLKREITFHGAKEVALSYSoGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADS.......	1	0	0	0
+2579	PF00599	Flu_M2		Influenza Matrix protein (M2)	Bateman A	anon	Bateman A	Family	This protein spans the viral membrane with an extracellular amino-terminus external and a cytoplasmic carboxy-terminus.	25.00	25.00	25.50	25.50	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.24	0.72	-4.20	2	21616	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	21060	57	0	4083	0	92.50	89	100.00	CHANGED	MSLLTEVETPh+stWECRCsDSSD.LVshASIhGILHLILWIhDRLFFKChYRRh+aGLKRGPuTuGlPESMREEYRQEQQSsVsVDsGHFVNIELE	....MSLLTEVET...PhRNEWECRCsDSSDPLVlAAsIIGILHLILWILDRLFFK...CIYRRFK..YGLKRGPSTEGVPESMREEYRQEQQsAVDsDDGHFVsIELE.............	0	0	0	0
+2580	PF00506	Flu_NP	flu_virus_nuc;	Influenza virus nucleoprotein	Finn RD	anon	Pfam-B_10 (release 1.0)	Family	\N	25.00	25.00	27.70	26.80	16.80	16.10	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.60	0.70	-6.01	3	18503	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	18183	20	0	6541	0	474.40	89	99.75	CHANGED	MAs.SsKR....S.EphpTuuE.......QpRQTPTEIRKSVupMVsclGEFYIQMCsElGLNsDhEtpLIQNuIAIERhlLuAsD-K+sEap+EKsAR-spcucushDscKTGGslYKRsRDGKsIpapslllLasKEEI+pIaK.oshGsD......AsuGLsHlMIaHSNLNDlsYQRoRALsRsGhDPcLhSLhQGSTLPRRSGAsGsAlKGlGTLVAEAIRhI......KRGlsDRshLR...ut+T+oAYERhhpsLKsKspsusQRALsDQVlcSRNPGsA-IEDLslLARSuLlLRPSVAsKssLPhClYhhA+lothDFpsEtYShVGh-AFcLaNhAp......sFSllRsNDDs....cDKSQLlaMACFGAAYEDLRVlSAlsGTclKPRupLKs+GF+VsusEpVETMsSuLLplRhpaWAshTRSGGNpssscuuuGQISsSPVFAVERsIsh-+QsVcchLohNlEGR-uDs+ssLlKMMc-uhu....pKoEssuFlG+uMF-LSDccKTNPI..sF+poscsFFFttDsAEDYDs	.....................................................................MASQGTKR....SYEQMETGGE.........RQNATEIRASVGRMlGGIGRFYIQMCTELKLS.DYEGRLIQNSITIERMVLSAFDERRNKYLEEHPS.......AGKDPKKTGGPIYRR.hDGKWMRE...LILYDKEEIRRIWRQANNGED......ATA..G.....LTHlMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMI......KRGINDRNFWRGENGRRTRlAYER.MCNILKGKFQTAAQR.AMMDQVRESRNPGNAEIEDLIFLARS..ALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGID..PF.+LL.QNSQ......VaSLIRPNENP....AHKS...QLVWMACHSAAFEDLRVSSFIRGT+VlPRGpLSTRGVQIASNENMEsMDSsTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATlMAAFTGNTEGRTSDMRTEIIRMMEuA.......+PEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDs.....................................	0	0	0	0
+2581	PF00600	Flu_NS1		Influenza non-structural protein (NS1)	Bateman A	anon	Bateman A	Family	NS1 is a homodimeric RNA-binding protein that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.	25.00	25.00	30.00	30.00	22.90	20.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.19	0.70	-5.20	3	18530	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	18330	77	0	6565	0	214.70	83	95.82	CHANGED	MDSNTVSSFQVDCFLWHIRKplADQ-MGDAPFLDRLRRDQKSLKGRGSTLGLDIEsATRsGKQIVERILKEESDEsLKhTIASuPASRYLTDMTIEEMSR-WYMLMP+QKlTGuLhIRMDQAIMDK+ITLKANFSVlFD+LETLlLLRAFT-DGAIVGEISPIPSLPGHTNEDVKNAIGILIGGLEWNDNTVRlSEsLQRFAWRsSDENGGPPLoPK	...MDSN.TVSSFQVDCFLWHlRKRFADQ-LGDAPFLDRLRRDQKSL+GRGsTLGLDIETATpsGKQIVE+ILKEESDEALKMTlASsPASRYLTDMTLEEMSRDWFMLMPKQKVt.GsLClRMDQAIM-KNIlLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHT.EDVKNA.IGVLIGGLEWNDNTVRVSEslQRFAWRSssEsGRPPLPP................................	0	0	0	0
+2582	PF00601	Flu_NS2		Influenza non-structural protein (NS2)	Bateman A	anon	Bateman A	Family	NS2 may play a role in promoting normal replication of the genomic RNAs by preventing the replication of short-length RNA species [1]. 	25.90	25.90	26.00	26.70	24.60	25.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.97	0.72	-3.78	4	18368	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	18223	2	0	3232	0	92.00	84	77.49	CHANGED	LNGMITQFEpLKLYRDSLGEuVMRhGDLHSLQsRNupWREpLuQKFEEIRWLItEsRphLphTENSFEQITFhQALQLLhEVEpEIRTFSFQLI	....LNGMITQFESLKlYRDSLGEAVMRMGDLH.LQsRNuKWREQLuQKFEEIRWLIEEVRHRLKtTENSFEQITFMQALQLLLEVEQEIRTFSFQLI....	0	0	0	0
+2583	PF00603	Flu_PA		Influenza RNA-dependent RNA polymerase subunit PA	Bateman A	anon	Bateman A	Family	\N	23.00	23.00	23.00	26.40	22.30	22.90	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-13.03	0.70	-6.50	4	18248	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	17904	29	0	9139	0	661.40	91	97.25	CHANGED	hsEhuEDhhhpss....+lhpIChHhpVChhhSDhcalscpGps...............pa-lIEGpcRshAh.l.pplCpppslEhP.+aLsDLaDhccppFlElGlT+chsD.Ya.pKhpKl.ussh+lhlFSasG.-hspss-hsLcEEp+tRIhohLsphtp.lspcNLapplhts-stEptI-..FclGpThpcL..RDpS...lP.sFpshEth+sYh-th..sPR.tlEsplupMpsplph..c.hchsphR.ItL.....-GP.sPapuhhLhtDuhhls.ls-PppcptuI.hh-.....phhasps-..hI+.p-Ks.susahh.....Wpplhuslpshtp......o.shp+sspscaAhG.shs.cKl.....ppsshsspshKQtEsclPEhpSlssWlpsEhshhpp.o-.stWl-LsEhsssss.lEtlApthpchahs.lsts+suphhhKhllhsTuLhspspsshu+hpllPIhsRshsccu........pphspLaGhslKGpSHL+pDTDsssllohEFShpDPcl-..Ka.KYoVFclGphh........VtG+phshaLYsRssuhSKIKhcWh.chRRCLlQohpphEsll.pESuhpppshsccsh.....Nc.pha.IGpppGtl.ttoltcslRslLspphhhslYsssQLEGFsAEpR+LLhslpAh+-p+p...PasFc.EGhh-tIEEClINNPhVlh.AphaNphlh.shc	.................MKEYGEDPKIETN....KFAAICTHLEVCFMYSDFHFIDERGESIIVESGD.PNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKP.KFLPDLYDYKENRFIEIGVTRREVH.IYYLEKANKIKSEKTH.IHIFSFTGEEMATKADYTLDEE.SRARIKTRLFTIRQEMASRGLWDSFRQSER.GEE.TIEE+FEITGTMRRL..ADQS...LPPNFSSLENFRAYVDGF..EPNGCIEGKLSQMSKEVNA+IEPFLKTTPRPLRL....P-GPP..CpQRSKF.LLMDALKLS.IEDPS.HEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLL....AWKQVLAELQDIENEEK.IP+TKNMKKTSQLKWALGENMAPEKV......DF-DCK...DVuDLKQYDSDEPE.RSLASWIQ....sEFNKACELTD..SSWIELDEIGEDVAPIEHIASMRRNYFTA.EVSHCRATEYIMKGVYINTALLNASC...AAMDDFQLIPMISKCRTKEG........RRKTNLYGFIIKGRSHLRNDTD.VVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLR....TAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFF....ENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLE...PGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHAL.K.........................................	0	0	0	0
+2584	PF00602	Flu_PB1		Influenza RNA-dependent RNA polymerase subunit PB1	Bateman A	anon	Bateman A	Family	Two GTP binding sites exist in this protein [1].	20.70	20.70	20.80	21.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	740	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-13.07	0.70	-6.81	5	18462	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	18111	8	0	8861	0	698.20	94	98.09	CHANGED	M-l.NPtLLFlc...VssQssISTTYPYTGPPPhSHGTuTtYTL-TVpRTacYSc.KuKpppscVsGss+l.cssNssL-EDNhsEPSGsAclDsVLtLhcph--ca.PGhFc+ustEAhEclhppcas+LTcGRQTaDWTssRNQPAATALpsTI-sh+pN.LsuscGsoMl-alcclhEsLD.+pElcFp..ssKshcR....+hcDppotthlp..cKphsKtcs+Is+cEYlpRALTLNTMsKDuERGKLcRRAIATPGM.lRGFVhlVEslA+sICEpLcpSGLPVGGNEKKAKLuosVcclhsp.ssuplosTlTGDNoKWNEChsP-saLAMlshIT+DuPpWh+-lhSIAPllFSNKhA+LGcGlhhpsKTp+pcslI+A-sluchc.ctFNEcp+stIcclEshl.p-GsspLosGMhMGM....FNMLSTVLGVSsLuhspcclsspthhWDGLQSSDDFlLFssA+Na-shppsl-cFh+lCKLlGINMSpKKS.YlstTGlFEFTSMFaRcGFVuNhAMELPSFs.suGlNESuDhulGholIKNNMINNsLuPuTAphAL+IFIp-YRaTY+sH.hDoclpsRRhKhLKchhcpppuKDGLLluDGGPslaNl+sLHIPElsLKa-..LMDE-Y+sRlhNPpNPFsu+spIE..cpsslFcAHGPl.+shEp-AVuoTHSacT+RNRolLNTcpRshlt-EQpYQKsCNlFEcsFsSuohRsPlG.tShhEAhtcRLc....cu+LctEuGRlpc-Ea-c	............................................MDV.NPTLL.FLK...VPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSE.KGKWTTNTETGAPQL.NPIDGPLPEDN..EPSGYAQTDCVLEAMAFLEESH.PGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMD.KEEhEIT..THFQRKR.....RVRDNMTKKMVT...QR.T..I...GKKKQRLNKRuYLIR.....ALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEK..LE..QSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNEN..QNPRMFLAMIT.....Y.............ITR........N..QPEWFRNlLSIAPIMFSNKMARLGKGYMFESKpMKLRTQIPAEMLAsIDLKYFNEST+KKIEKIR...PLL.IDGTASLSPGMMMGM....FNMLSTVLGVSILNLGQK+YTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKS.YIN+TGTFEFTSFFYRYGFVANFSMELPSFG.VSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLW-QT.pSKAGLLVSDGGPNLY...NIRNLHIPEVCLKWE.....LMDEDYpGRLCNPLNPFVSHKEIESVNNAVVMPAHGPA.KSMEYDAVATTHSWIPKRNRSILNTSQRGILED.E.QMYQKCCNLFEKFFPS....S....SYRRPVGISSMVEAMVSRAR...ID.A.RIDFESGRIKKEEFu.......................	0	0	0	0
+2585	PF00604	Flu_PB2		Influenza RNA-dependent RNA polymerase subunit PB2	Bateman A	anon	Bateman A	Family	PB2 can bind 5' end cap structure of RNA [1].	25.00	25.00	37.80	37.70	17.90	16.50	hmmbuild  -o /dev/null HMM SEED	759	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-13.23	0.70	-6.68	6	18433	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	18053	21	0	9733	0	710.70	92	99.89	CHANGED	MERIKELRsLMSQSRTRpILTpTTVDHMAIIKKYTSGRQEKNPuLRMKWMMAMKYPITADKRIhEhIPERNEQGQT.LWS+TsDAGS.DRVMVSPLAVTWWNRNGPsusThHYPK.VYKTYFEKVERLKcGTFGPVHFRNQlKIRRRVDlNPGHADLSuKEAQDVIMEVVFPNEVGAplLTSESQLpITKEKKEELQ-CKIuPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGsCWEQhYsPGGEVRNDDlDQSLIIAARsIVRRAsVSs.DPLuSLLEMCHST..QIGGs..RMVDIL+QNPTEEQAVDICKAAMGL+ISSSFSFGGFTFKRTSGSSVKREEElLTGNLQTLKIclHEGYEEFThVGK+ATAILRKATRRLlQLIlSG+DEQSIAEAIIVAMVFSQ-DCMIKAVRGDLNFlN...RANQRLNPMHQLLRHFQK...DAKlLFQNWGIEpIDNlMGMhGILPDMTPSTEhSLRGVRlSKhGVDEYSSTERlVVSIDRFLRVRDQpGNVLLSPEEVSETQGTEKLTITYSSSMMWElNGsESlLVNTYQWII+NWET.....VKIQWSQDPThLYNKhEFEPFQSLlPKAtRGQYSGFVRTLFQQMRDVLGTFDTsQIIKLLPFAAAPPKQSRM..QFSSLTVNVRGSGMRIL.VRGNSPVFNYNKsTKRLTlLGKDAGsLscDPDEGTs.GlESAVLRGFLILGKED+RYGPALSIsELusLAKGEKANVLIGQGDVVLVMKRKRsSSILTDSQTATKRIRMAlN	....................MERIKELRsLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIhEMIPERNEQGQT.LWSKTNDAGS.DRVMVSPLAVTWW..NRNGPTTSTVHYPK.VYKTYFEKVERLKHGTFGP..VHFRNQVKIRRRVDlNP.GHADLSAKEAQDVIMEVVFPNEVGARIL...TSESQLTITKEKKEELQDCKIA.PLMV..AYMLERELV.RKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAsVSA.DPLASLLEMCHST..QIGGl..RMVDILRQNPTEEQAVDICKAAMGLRISSSFS.FGGFTFKRTSGSSVK+EEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVN...RANQRLNPMHQLLRHFQK...DAKVLFQNWGIEsIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWEs.....VKIQWSQDPTMLYNKMEFEPFQSLVPKAsRuQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRM..QFSSLTVNVRGSGMRIL.VRGNSPVFNYNKATKRLTV.LGKDAG..ALTEDPDEGTu.GVESAVLRGFLILG.KEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN...........................................................................	0	0	0	0
+2586	PF03069	FmdA_AmdA		Acetamidase/Formamidase family	Bateman A	anon	Pfam-B_2541 (release 6.4)	Family	This family includes amidohydrolases of formamide EC:3.5.1.49 and acetamide. Swiss:Q50228 forms a homotrimer suggesting all the members of this family also do.	19.50	19.50	20.10	19.50	18.90	19.40	hmmbuild  -o /dev/null HMM SEED	369	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.13	0.70	-5.76	8	1881	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	808	40	759	1832	361	191.80	18	81.87	CHANGED	sllslD+sK..hcpss.hHNRWHP-lsssApV+PGEpl+lEshDAhGGQIpss-u...usDlcslDLoplH.LoGPltVcG.....AcPGDlLhV-IhDh.slc.......sct...GasGhFs+tsGuGFLsD+..ascstKslW-acGhassScplPGVRaPGhsasGVIG.sAPSc-lLsphscRE.t.ltpss..s..hs..Ppsp.th...........tlAsEuhRTlPsR.-sGGNhDlKslo+GS+lahPVFVEGAhLShGDlHaoQGDGElshs.AIEMuGplsl+lclIKsG.lcphslcs........Pha..u.l.cPpap..calhhpGluVD-uh.+pthhssshAh+puhLNsIsahc+aGYsstQshlllSsssspu....hVs.ssusssstlP.stIFpps	............................................................................tt..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sG..D...h..Gs.hhh.l...su.h.hGs.+h..u.uc.s....sh-..........h.h..h..................................................................................................................................................................................................................................s...................................................................................................................	0	226	478	623
+2587	PF01070	FMN_dh		FMN-dependent dehydrogenase	Finn RD, Bateman A	anon	Pfam-B_829 (release 3.0)	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.68	0.70	-5.61	180	7189	2012-10-03 05:58:16	2003-04-07 12:59:11	13	28	3457	189	2186	12550	8912	259.10	23	86.79	CHANGED	A.+cpLPth..sasYlsuGAssEhThpp.NpsAFpchpltPRsL..psls...ph..chs..sslh.....GpphshPlhlAPsGhptLhas.c..GEl....shA.+AAsptGl..shslSohusssl.....E-l......up.s..............ss........ssh..WFQLYh...pDcshsppllcR.Ac..sAGhcuLllTVDsPshGpRc..p-hRssh....th....P.th.......hthh.phh.ts..............................tt................................................................tssth.tthht..h...p.....ss.lsW.cc.lphLRp..t.h..shPlllKGl...hss-DAttAhchG..sD.GIlVSNHGGRQ...........................LDuususl-sLPpl.sp..sl.s...............................sc.....htlhlDGGlRpGsDllKALALGAcuVhlGRshlaGLA.ssGptGVp+slclLpsElctsMsLhGssslscl...st.sh.lpt	...............................................................................................................................................................................................................................................................................................................................ts.hp.ph.hh.phl........hs.h.p...p.h........s..h..p..sph....h.................s........p..h........t..hPhh..hssh.s.....h......t...t....h......ht...........p....hph...........thAp....s.st..t..h.....s..h....h......hh.u......o.s.....h..h.........p..h..........................................................................h.h...h...................t..................th.h.........tt...h.............t...........h........s.l...h..p.h.s...........................................................................................................................................................................................................................................hsh....pp..lt..ltp................h......t.....h.....P.hll..K...t.....l...................hs.......c...s........s.t............h.....h....p.......h....G.......s....p.....u.l......l.......S....s.....+....G.....G......p....p........................................................................h...D..h.....s.........s....s..............h......p...s........L..........t.l...hp....h...t..........................................................tp........h.l.hh.s.uG.lRpG.Dl.h+....sl.A.L.G.Ac....hshlu.Rshl....h.ul............t....h.t.............G................t............u..l.....p.h...l.p.h...h.t...t...-hchhMthhGspslt..plp......h................................................................................	0	652	1304	1811
+2588	PF00743	FMO-like		Flavin-binding monooxygenase-like	Bateman A	anon	Pfam-B_437 (release 2.1)	Family	This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	532	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.62	0.70	-6.31	5	2951	2012-10-10 17:06:42	2003-04-07 12:59:11	14	45	679	107	1914	7810	2768	277.00	19	77.52	CHANGED	AKKVAVIGAGVSGLuSIKCCLEEGLEPTCFERS-DIGGLWRFoEssEEGRASIYKSVloNoSKEMSCFSDFPFPEDYPNFMHNSKlLEYl+hFAK+FDLLKYIQFKTTVCSVsK+PDFSoSGQWEVVTE+EGKpcSAVFDAVMVCTGHHlNPHLPLESFPGIc+FKGQYFHSR-YKcP-uFpGKRVLVIGlGNSGuDIAVELS+TAcQVFLSTRsGSWVlSRluDsGYPWDMllsTRFsoFL+NlLPoslSsWlhE+QlNcRFNHENYGLpPcc+shtKEPllNDELPuRILsGtVpVKssVKEFTETSAIFEDGTlEEsIDlVIFATGYTFuFPFLEESlVKlccNclSLYKtVFPPpLEKPTLAIIGLIQPLGSIlPTsELQARWAsRVFKGLC+LPSppcMMpEIsc+pEc+hKhFG.spocslQoDYIsYMDELAsaIGAKPNLhSLhLTDP+LAlcVFFGPCoPYQYRLsGPGKW-GARNAILTQWDRoLKPLKTRlVpcSssPsuuF.hLKlFulslLLlAlFLlht	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s................t.....h.........................h.......................................................t..............................................a.....................t.......................h......tY..h.t..h..s.....t.......t.....h.....t.....h......................h.......h....t....t.........l..............................h..................................................................................................................................................................h..............................l..................................................................t...............................................................................h................p......h........l...........h..........h..s....s......G...........................s..............h........P........................................h..............s.....................t.....a....................s....t.........h..H.................u........................a........p...........t......s........t...................h..........t........s.....p..........p..........lh..ll.G....u..S.u.....-...l....s........p...h.......................s.....t.....t.....................................h.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.......h....................t.....t.......................................................D.....lhhsT.....Ga.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................thh...................................................................................................................................................................................................................................................	0	525	1056	1588
+2589	PF00039	fn1		Fibronectin type I domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.70	20.70	20.80	21.30	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.42	0.72	-4.15	20	1772	2009-01-15 18:05:59	2003-04-07 12:59:11	13	57	52	70	393	1849	0	38.10	42	17.20	CHANGED	ChD.posspYplG.-pWpR.tp..Gthhp.CpChGtGpGchpC	..ChD.s..GspY.pl.G.-pWc+.tp..G.hhhp.CTCh.Gs..G.pGcapC.....	0	20	53	138
+2590	PF00040	fn2		Fibronectin type II domain	Sonnhammer ELL	anon	Prosite	Domain	\N	22.20	22.20	23.60	22.60	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.60	0.72	-3.95	111	1582	2009-01-15 18:05:59	2003-04-07 12:59:11	14	126	87	45	677	1460	22	41.30	49	6.08	CHANGED	ChFPFhapGppYpsCTscGcs.tthW..CuTT.ssYDpDpcWua..C	...ChFPFhapGcpYpsC...Ts...cG.R......p.D.....uhhW..CuTT.tsYD...p...D...p...+...aGFC.................	0	92	123	281
+2591	PF00041	fn3		Fibronectin type III domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.73	0.72	-3.85	106	58087	2012-10-03 16:25:20	2003-04-07 12:59:11	16	3078	1986	274	27544	50190	2367	84.30	20	23.88	CHANGED	ssP.pslphpsh...sssslplsWpss.....suslssYplph....ptsssp...........hpphs...lsss....p...phslpsL.pPsspYphpVt.Ahsst.....t.S	....................................................P.tsl..p..h..p..sh......ss.s.....o...l..p..l......s...W.....p..s.........P................t..................s..........u...........t........l............p...........s...........Y..h.......l...p......h......ppt.sstt...........................................htp.h.s............h.s..s.s..................pp....p..h.p.....l.....s......s.....L...p.........s...s..........s.p.Y.....p....h.p..Vt..A.h.st.tG...u.............................................	0	7000	9544	17225
+2592	PF02986	Fn_bind		Fibronectin binding repeat	Griffiths-Jones SR, Schwarz-Linek U	anon	Pfam-B_2661 (release 6.4)	Repeat	The ability of bacteria to bind fibronectin is thought to enable the colonisation of wound tissue and blood clots.  The fibronectin binding repeat is found in bacterial fibronectin binding proteins and serum opacity factor.  Bacterial fibronectin binding proteins are surface proteins that covalently link to the bacterial cell wall, mediate adherence of the bacteria to host cells [2] and trigger the fibronectin/integrin-mediated uptake of bacteria by host cells [3]. Each fibronectin binding repeat is an array of short motifs that bind to fibronectin type I domains [4]. Fibronectin binding repeats are natively unfolded in the absence of fibronectin and are thought to adopt a well-defined conformation (tandem beta-zipper) upon binding [5].	21.20	21.20	21.40	21.40	19.50	21.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.85	0.72	-4.44	34	1694	2009-01-15 18:05:59	2003-04-07 12:59:11	9	50	190	4	23	1338	0	37.00	43	15.06	CHANGED	pslDhsE..DT.....suhS..Gpssss...oh.EDT+...Pp..hh.hGGp	......N.VDh-.Do....lPplp...Gp..Ncss..pshEEDTpt..sc..h...GG...........	0	6	6	14
+2593	PF03274	Foamy_BEL		Foamy virus BEL 1/2 protein	Mifsud W	anon	Pfam-B_4337 (release 6.5)	Family	\N	21.50	21.50	21.70	54.70	20.20	21.40	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.79	0.70	-5.12	6	21	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	8	0	0	35	0	218.60	34	59.84	CHANGED	hshsEhE.slu..ssEN....Ptc.+hhpp..pssst-spsVoYH.uYK-pEDpps.cI.KhcDWlPsP-cM.SKplCppLILssLYsupKAtEllp..................hsasVpW..EQScssPshFtl...pYpChhCpslha-PMPlha....DscsclWhKht.LRuslGSlVashc+Hhpp...Cpu.VcP.pp..pGps.......t+PRhRssPshRa.+hhtEasssR.+coK.hlsppspuHp......SsGDshAhts	...................shsEhE.slu..stpN....Ptcs+hhpp......tcspploaH.uY+EhE-pps.pl.KLpDWlPsP-cM.SKpls...........pp.lhshLhps.Kst-.lp..................hPhsssW..pQscssPshFtl....Ypshhspshha-Ph.hha....DPpschahthphLhsslGplshphaKphps...Cpu.lcP.ss..pups.........scPRs+ssPsLpa.+hhhctshsRp+cp+.hlh+hspuHc.ss...SsuDhhAhp...........	0	0	0	0
+2594	PF03408	Foamy_virus_ENV		Foamy virus envelope protein  	Finn RD	anon	Pfam-B_4411 (release 6.6)	Family	Expression of the envelope (Env) glycoprotein is essential for viral  particle egress.  This feature is unique to the Spumavirinae, a  subclass of the Retroviridae.	20.10	20.10	20.40	24.00	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	981	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.94	0.70	-13.61	0.70	-7.02	7	89	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	14	0	0	86	1	583.90	52	99.33	CHANGED	MTLpQWl.W+thppspphLpshssl..pphp.slh-hpt-EhlPh+h.RhKYhhYsCCATSTRlhsWlhhlClLL.lVhlSshlTlhRlQWppsIpV.GPVlsWNlopptshpshpst+luRphRs.H.t.p.VpVNhTSIPQGVaapPHPcPIIhKERVLGLSQVlMIsS-sIApstNLspEsKsLLs-MINEEhpsLusshlsFElPLGDP+sQ-QYIH++CaQcFAHCYlV+Ytss+sWPocplItDQCPLPsh.ass.tYphQsIWDYYl....htPpsWsscsh..YGp....ARlGuaYlPp..hppshoHVlFCSDQLYucWYshppo.pppEcLhhpKLhN..Lspts.upLKcRALPssWsspGputLFR-lNsLDhCs+PEAVhLLNpoYYsaSLWEGDCshpppsIoph.spC+sa.pp...pphHPYACRFWR....pp.tp-EhKChssEp..+CLYaPpaDosEtt.DFGaLAY.ssFPSPICIcppslp-.cYcV.SLYtEChppucpYGIcsVl.tLcshLs.sGhsls-hPsuRAFssLss.paPsoY.NhTpp.pppuC....s+RpRRSl..sNac+LpohGhuLssAlpTLSpISDlNDEpLtpGlaLLRDHlVTLMEAsLHDISlhEuMhulQHlHTHLspLKshLLtpRIDWoaIpSsWIQpQLQto--.MKlIRRTARSlsYhVpQTpsosTuTuWEIGIYYEllIPK+IYLsNWplhNlGHLl+sAGaLT+VplpHPYEIlNpECppppYLHLE-ChcQDYlIC-.V..VpPCGNsTs.SDCPVhActlKsPYlplpPLKNGSYLVLoSpTDCuIPsYlPslVTVN-TlcCFGhpFK+PLhuEp+s.sapPplPpLcLRLPHLlGIIAKlKulcIEVTST.EsIKDQIcRAKAELLRLDlHEGDaPsWlpQLusATcDVWPAAAsslpuIGNFLussApGIFGTsFSlLuYsKPlLIGlslILLllLlhKIlSWLss..c+K+p	....MTLQQWLlW+..........KMs-AHsALpNsooLTEEQKpQlIlEIQ...pEEV.l..PT+MDRlKYLsYsCCATuTRVMsWlhLIClLLIIVhVSCFVTVuRIQWN+DIsVhGPVIDWNVT.pp.AsY.QpLpssRloRSLRspHPc.pYlplNMoSIPQGVhYsPHPEPIIlKERVLGlSQVLMINSENIANsANLoQEsKhLLs-MINEELpsLSspMIcFELPLGDPRDQpQYIH+KCYQEFAHCYLVKYKp.P.psW.o-slIsDQCPLPGh.HssshYcYQsIWDYYlphppIRPpsWTocoa..YGs....ARhGSFYlPp.hRpssloHVlFCSDQLYGKWYNlpNslpENEpLL+oKLhN..LTsh..SpLKsRALPppWsspGpucLFRshNsLDlCN+PEAVLLLNoTYaoaSLWEGDCsaTps.Ipph.sEC+p.s+h...chhHPYACRFWR...aKp.spEEVKChssEc.c+CLYYscYsSPEupaDFGFLuYLsAFPu.hCIEspslR-s-YEVYSLYhEChNuAcpaGIDoVLhuLKoFLNaTGsPVNEMssARAFlGLoDPKFPPsYPNlT+E..p+uC..ps.pR++RS...sNlcKL+SM...............................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2595	PF03623	Focal_AT		Focal adhesion targeting region	Bateman A	anon	[1]	Domain	Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [1]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.	21.20	21.20	21.70	21.30	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.62	0.71	-4.69	7	286	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	84	30	140	236	0	126.30	54	14.58	CHANGED	TtsLDRosDhVYpsshslVKuVhpLpstlpphssp-YlshVKsVGlsLRsLlsoVDclhssLPups+pEIEhspKlLsKDhuELIutMRLAQQ.uhToLcp-h++pMLoAAHsLAhDAKNLLDsVDpARl+hphhh..Pt	................TAsLDRosDpVYpsVsslVKAVlphssclp.us..PEp.YVs.hVKpVGLsLRsLluoVD-hlPhL.P....uSo.++E.I...........EMA..p..KLLN.pDLuELIsKM.+LAQ.Q...ash.TSLp.pE....YKKpMLoAAHsLAlDAKNLLDslDQARl+h.h.....t..................	0	58	67	101
+2596	PF02980	FokI_C		Restriction endonuclease FokI, catalytic domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	104.30	103.10	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.71	0.71	-4.53	4	21	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	21	3	3	25	0	139.00	41	24.27	CHANGED	upEc-lLhpAlLuYPPAspILoLLt-t.GpahTKF-LGcpLGFhGEpGFTShPpsIhlcsLAsup.st-K...pKIKosaEGoSDKYARhIusWLcplGLVpptsKpVhh.ThtpRKap..lupsa.ITu.GlpsLpcspGpoRas	....t.p-pclLpcAlLuYPPAsplLsLLsst.upthTKFpLGcpLGFhGEtGFTShsp-lhlpsLspAp.sp-K...pKI+SshEGTSDKYARhIsuWLhplGLVpppsKclsh.shssccap..shs.psYpITs+GlpAL+pspGpS+a.s.......	0	1	1	3
+2597	PF02981	FokI_N		Restriction endonuclease FokI, recognition domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	29.00	27.50	22.90	19.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.70	0.71	-4.58	3	21	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	21	3	3	25	0	143.20	34	25.01	CHANGED	lhloEsS+lR..TFGWVQDPS.DF+sLs+VVuIFDcsSKlHpELtsp+IPsLVcEpclRpELlullNQ+PLplTYK-LVGTuho.RScAcCNuIVQAsl..pGQ.sRsaIsDWuADNFVRWAHALGFL+YtppuDoFsITElGlAhuKutD	..............chR..TFGWlQssS.shppLKKVVslFsssSchappLhcshlt.pllp-tsh+pcLhscLsss..shphoYhcLsGss.......h.......p...........RocuhssuLlQAsl.....puQ..u.....+tahcDWsADuFLRWAVulsFlcaspcsDTFsITchGhphsp................	0	1	1	3
+2598	PF01770	Folate_carrier		Reduced folate carrier	Bashton M, Bateman A	anon	Pfam-B_1123 (release 4.2)	Family	The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy [1], such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.32	0.70	-5.96	24	433	2012-10-03 03:33:39	2003-04-07 12:59:11	13	6	105	0	249	620	26	306.20	34	82.78	CHANGED	psWhh.ohlLChaGFhpphRPuEPFlssYLhGs.+NlTp-QlssplaPVhTYSYLAhLlsVFLlTDaLRYKPVIlLpuluhlssahlLlaspulhshQhhEhFYGlspAuElAYaoYIYuhVs......ppYQ+lTuYoRuuhLlGhhhuulLuQlLVo....hsthsahpLNhISLushsluLhhuhhLPtsp+SlaFppp..............................ppscspphppsppps......hpt.t..shpt...psl....tthhpchtssYss.pllhWSLWWAhuouGahQllsYlQlLWcpl...sspssplYNGuV-AsuTLLGAlsuhusGal..phpashautLsLulhSslpuGhlhlhshop...sIWlsYsuYllF+uhYhFlITIAshpIAssLsh-paALVFGlNTFlALhLQTlLThlVlD.ppGL..sLslpsQFhV	....................................................................W.h.shhLCh.aGhhtth+P..u.Esalh.aL.h.t....p...NhTtpp..l..p...........plhPhhoYS..als.hL..h...lF..l...hTDhl.RYK........Plllhpu.hu..hlh.h.ahh..Llhs..ps..l...hthQh...............hphha................u..........hh....h.A....s.c.l....A.Y...u.Y.Ia.u....h..V.p........................th..Yp.+.h..s....u.a.s.R.u.s.h....Lhu.hhhuul....lu.Q.lhls.....ht....hs.hh...L..thlo.....l.s.....h....uh..h.h.u.h.h......L............sppo...h......aa...pt................................................................................................h....hh.........h.hhtc..h..ht.s.h.pp....lhhWSlWWsh.s..ssGa..lh.....................YhphLWp.h..........pt..t.haNG.ss-A.h.shh........uu.h..ss.hhsuh..l..php.h.sh.h.u.....h.hlshho....h..h..u.s..lhh.h.t.....st.......sI....ahsYss...al.lat...Y.h...h.l...sl........A......hp...lA...........sLs......-.huLlFGhNTFhAhhlpollThl.Vss.ttuh...sL.l..Qah...............................................................................................................	0	72	94	174
+2599	PF03024	Folate_rec		Folate receptor family	Bateman A	anon	Pfam-B_1966 (release 6.4)	Family	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.	29.50	29.50	30.30	29.50	29.10	28.90	hmmbuild  --amino -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.94	0.71	-12.36	0.71	-4.63	34	433	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	99	11	239	412	3	158.80	26	42.97	CHANGED	hCh...........su+paKshPusEspLt.p..........Cssapcp............................uCCssspopphpps.s.hl.ph.hp+CGp...hospCccahhp.pChYcCSPplu.W.............................p...ppth.slP.LCp-.CcpWacsC+ssh...TCsssW.t...athspst.ppC..tst..Chsappha.ssss-LC...................cplaupuaphustt..................uspClp	...................................................Chstp..pp.stsc..tpLh............Cs.appp.................................uC....Cstspspphttp.t........hh..............h.......up...........hp.stCpcahhphtC.hcCSPphu.h....p.....................tp..pphhhslP.LCp....-hCppaap...sC+ssh.......ps....tssh....................pps...h...p.C........t.....C..h.p.hh.....sssshC........pph.hu.s.hthss.....................sthCh................................................................	0	66	87	135
+2600	PF02152	FolB		Dihydroneopterin aldolase	Bateman A	anon	PSI-BLAST P31055	Domain	This enzyme EC:4.1.2.25 catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	24.10	24.10	24.10	24.40	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.15	0.71	-3.91	129	4525	2012-10-01 20:59:24	2003-04-07 12:59:11	13	22	3833	60	1029	2777	2126	111.20	28	72.22	CHANGED	lhlcsLchhuhlGlhstE+thsQphhlDlpl....thchp...tssts.Dclppol....sYsplsctl.tphsp.ppp...apLlEsLAcpluptlhpp...........................as....lpt......lp.lplpKPss..ls.tsss.......lulplpR	................lhlcsLchhshhGlhstEpphtQchllDlpl.........thD...hp.........pAupo...D-.ls.c.s.l........s.Y.upl.scpl.tphlp...s.pp...........hpL..lEplApclAchlhpc................................as.....lpt..........lclclpK.PpA..ls..thcs.VuVplpR.................................................	0	309	627	864
+2601	PF00250	Fork_head	FKH;	Fork head domain	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	21.00	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.24	0.72	-3.94	21	4445	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	545	35	2306	4173	4	92.50	42	20.59	CHANGED	KPP.....................YSYhuLIsMAIpp.uPsKhLTLupIYpaIh-pFPYYRpNppuWQNSIRHNLSLNcCFlKVPR......ps-cPGKGuaWpLcPsutshF.s................Gsah+Rc+R	........................................KPP.......aSYss.LIsh.A...Ipp....o.sp+pLTLs.pIYpa..Ihcp..FP..Y..a.....R..........p......s.....p......t.....u......W............p..............NS.IRHNL..SLN.c.C.FlK..Vs..+................t.....s....p.....s...G..........K................G..s..a.Wsl..c...Pss.t....p.h...h.t.......t...............................................................	1	603	883	1588
+2602	PF01226	Form_Nir_trans		Formate/nitrite transporter	Finn RD, Bateman A	anon	Prosite	Family	\N	28.20	28.20	28.60	28.50	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.70	0.70	-5.48	190	4680	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	2481	80	683	2429	127	247.40	28	87.19	CHANGED	stphhpthhps.uhpK...hptshhphhltuhhAGhhIuhushhthhlsssh.................s...........uhspllsuhs.FslGLlllllsGu-LFTuNshhhshuhhpc+..loh.tpll+sWsllalGNhlGulhhuhlhshs...shht...........ts........thstthhplAp......tK..h......sh.s.............hhpsFh+GIhCNaLVsLuVWhsh.uu+sh..huKlhslhhslhsFlssGFEHsVANMhhlshu.......lhh.us..........................s.hhshhhpNllPVslGNllGGslhluhhhahha	..............................hthh.pt.u.tc...hp...ps.h.ph..hlhuhhAGhalul..uhlhhhshssth.................ss................uhsp.Lls.uhs.FslGLllllls.Gu-LFTusshhh....sluhhp..pp.......loh..sp..hh.......p.ahh.........shlGNllGulhhuhlhths..shht...............s.......................................thspt.hh.pl.up.tK.h................pp..s.....................................h.hphhhpGIhsNhhVslAlWhsh..t..s.c.ss..hsKhhshhhslhhFlhsGaEHs........lANhhhhshu...lhh..sp.................................s.hhsh..lhpNllsshlGNllGGulhhGLsYahh................................	0	205	396	569
+2603	PF02971	FTCD	formiminotr; 	Formiminotransferase domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	24.00	24.00	25.40	26.60	22.80	23.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.74	0.71	-4.56	4	394	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	349	6	124	337	180	124.30	43	33.96	CHANGED	FLIAFNINLLuT+..E.AHRIALslREQGRGtDQPGpLKKVQuIGWYL-E+NlAQVSTNLLDFEsTsLHsVaEEsChEApcLuLPVVGSQLVGLVPLKALLDAAuFYhcKEpLFlLp-E++I+LVVsRLGLDSLsPFpP+ERIIEYL	...............LlAaNlNL...s.T.s..l-IAccIA.KtlRtpu.......................................................................GGh+alKAlGl.Lc.......-+.....slsQVShNlsDap+TslaRsFEpl+hEAc.RaGVsVlGSE....llGLlPhcALlDsAcYYL.p....h.E.s.h..........................................................................	0	62	84	104
+2604	PF02911	Formyl_trans_C	formyl_trans_C; 	Formyl transferase, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-3.92	130	5755	2009-01-15 18:05:59	2003-04-07 12:59:11	13	28	4563	24	1384	4263	2359	99.70	28	26.51	CHANGED	+lspp-stI-W.spsAppltphlRuh...s.PaP.uAas...hh....ss.......p....pl..........+lhcs.......phh.....spttttt.......................PG...p.....llphspp.slh.lssu.sus......ltl.ppl..Qhtuc+hhsspshhp....Ghp	....................pls+--ucI.D.W...spsApplppplRuh........s..PaP..sAas....hh..............ss..........p...........pl...................................Klapu.....................phh...........ssss.stt.....................................................PG....p.......llp....s...s....cp....slh..lAsu..sGs...............Lpl..tpl..Q...sGK+.t.h.sstsahpGh.t.........................................	0	435	862	1141
+2605	PF00551	Formyl_trans_N	formyl_transf; 	Formyl transferase	Bateman A	anon	SCOP	Domain	This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces formate from formyl- tetrahydrofolate. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. Inclusion of the following members is supported by PSI-blast. HOXX_BRAJA (P31907) contains a related domain of unknown function. PRTH_PORGI (P46071) contains a related domain of unknown function. Y09P_MYCTU (Q50721) contains a related domain of unknown function.	20.80	20.80	20.90	20.80	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.94	0.71	-4.74	15	13471	2009-01-15 18:05:59	2003-04-07 12:59:11	14	85	4844	104	3486	9789	6453	174.10	26	55.92	CHANGED	h+lsllhSGsu.oshpsl.lsth+psstp...spllhVlos+spstGhp+utpsslsptlhpcps...................apsc.tthcpcltctlcthpsDllllAuah+lLssshl.pthss+lLNlHPSLLPpa.....cG.ssslppAlhsGscc.....sGsTlaals.-plDsGsIlhQpps.lhs.s-ossslppRlp-tEt.pshscsl	.........................................................................................................+lhhh...Gp...s....p.....h..t..sl....l.p...t.hh.ts.th.............ls..s..Vh..o..p....s.c...s...h..s....h...t.t......s..h.p.....h..s......s..t.h.h....h.....t.ps..............................................h.psp...t..h.c.p...p....h...h....p...t...l...........p.....p...........h.......p...s.....D.....l.l.VlA.u.Y.h.p..l..Ls.sp.ll....p.........t..h..............t.....t.............t......h..l.NlHs...S..LLP........pa...................+.G...usP.h......pp...A...l........s....G.s.c.............................sGsTlH.....h.l...........s...p...........t..lDsG.s.Ilt.Q.t........t....l....s...l........pt...sDost...s.Lh.p.+l.t.p.h.tt.pl.lsps..............................................................	0	1084	2180	2908
+2607	PF01491	Frataxin_Cyay		Frataxin-like domain	Gibson Tj, Bateman A	anon	Gibson TJ	Domain	This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia.  This domain is found in a family of bacterial proteins.\	  The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.	21.30	21.30	21.80	21.80	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.65	0.72	-4.26	96	1466	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1409	24	414	878	102	106.10	41	86.45	CHANGED	hs-scapplu-phlpplE-tl-th..-ss.....................hDlDs-hs.uGVLTlpF.s.stuphlIN+QsPh+QlWLAo..SGGaHFcap................s.sp..W.lss+.sGp.phhshLscthsppsups.lpas	...................................Ms-oEFHcLADphh.sIE-plDph..-.uc.....................sD.l.DsEh.s....GG.VLTlsF.....-suS......pIlIN+QpPh+.QlWLA.o+.pGG...aHFchp.....................s..sc..Wl..........ssR...sGp.shaclLpptsoppuGcslph.p..........	0	105	209	318
+2608	PF03197	FRD2		Bacteriophage FRD2 protein	Mifsud W	anon	Pfam-B_2816 (release 6.5)	Family	\N	21.60	21.60	21.80	50.80	20.90	18.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.32	0.72	-3.47	6	36	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	32	0	0	28	0	99.60	58	79.79	CHANGED	sMVclIc-NGGWFEVK-hpss.DGh.csVs+IpCANGcha.ssG.h-pYFEIpEDEF+CFREY...TsEcDElcccV..oGVTKIHCIVDENNVDEIIELLRKTFKK	.sMVclIpENGGWFEVK-htsh.DGa.chVp+IpCANGcha.s..G.h-cYFElsE-EFaCFREYKE.TSEcD-lcDcV..SGVTKIHCIVDENNVDEIIELLRKTFKt..	0	0	0	0
+2609	PF04422	FrhB_FdhB_N		Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	Kerrison ND	anon	DOMO:DM04087;	Family	Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420.  This family contains the N termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2].  The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.47	0.72	-4.12	116	542	2009-01-15 18:05:59	2003-04-07 12:59:11	8	32	327	0	298	541	181	79.70	26	20.16	CHANGED	tchhtApusst..hppuQsGGhVTulhthhL-pGhlDuVlsst....psp...................c.acshPhlssss--lhpsu..Go+as.hsshhphlcc	...........t.thhhApsp.p...hp.tupsGGlVTslhthhL-p.G.hlDuVlssp....psp................................c.a.pshshlspss--llp........ss..Go+as.hsshhphlt................................................	1	80	189	254
+2610	PF03881	Fructosamin_kin		Fructosamine kinase	Bateman A	anon	COG3001	Family	This family includes eukaryotic fructosamine-3-kinase enzymes [1]. The family also includes bacterial members that have not been characterised but probably have a similar or identical function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.81	0.70	-5.43	35	2015	2012-10-02 22:05:25	2003-04-07 12:59:11	9	10	1716	3	561	1603	432	272.80	31	95.06	CHANGED	MWpuIup.lo-phGpsapIpc+pplsGG-Ispsahls........cuppcaFVKlNp..cshLshFcuEA-uLphLscopolpVPcslshGss.cspu............aLlLEaLshp.hsstcsthphGppLApLHp.......hssptpFGa-hDNhlGsTsQPNsWpccWusFFu-QRIGaQLpLsc-+Gh.p...husl-pllcpltphL................ssHpPpPSLLHGDLWsGNsuhsss.G..........PllaDPAsYaGDREsDLAMoELFGGFPssFYcGYpslaPLs...sGYpcRKslYpLYHlLNHhNLF...GGpYlspApphlcpl.Lpp	......................................................................................................................................................................................................h..ht.ls..G.Gp..lp.t.s...a.t.....lp...............h.stp....p.hFl..K..spp...............tph.....h.s.....h..F.p....u..Es..s.tL....p......h......l....t.....c......s........t.......s.........l..p..........l.Pcl..h......s..s....G.ts...p...s...t.u.....................................a...Ll.h...-........a.....L.........s.......................t.....................s...........s.........ps.........s..........hpL........G.pp.........lA.c...LHp.................................hps.pspF.....G..........a.....c.....hs.....s.....t.....h.G.s.........h.....s........Q....s.....N......s........W........p.....c......c.....W...s................s...FF....u...c...p.R.....l....s.h.........lc..h..s.t...c..+...Gh.h..............hsp.h.c...p....l..h....c....p...l..t.p..t..L...............................t..s...+..p.s.....p...P.SL...L.......HGDLWuGNshhsss..G...............................................Ph...laD....P.A.....s.a..a.GcR............EhD..L.....A......h....h..t..l.....F...........s...s....h.....s...s..p........h...a.c.uY...pp....h.....h.....P....Ls.....ts.a...pc.Rhsl.YpL.Yh...LL.s.+.ht.hF...G..u.t..ahs.tstp.hcplh..t..........................................................................................................................	1	143	323	454
+2611	PF04961	FTCD_C		Formiminotransferase-cyclodeaminase	Bateman A	anon	COG3404	Family	Members of this family are thought to be Formiminotransferase- cyclodeaminase enzymes EC:4.3.1.4. This domain is found in  the C-terminus of the bifunctional animal members of the family.	21.80	21.80	23.30	23.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.73	0.71	-4.87	75	717	2009-09-11 00:17:51	2003-04-07 12:59:11	7	8	621	6	232	659	206	179.80	33	69.85	CHANGED	holp-FlctlAScsPsPGGGSsuAlsuAlGuALssMVupLTl.GKKpYtph-s....phpplhppscphppcLhshlDcDscAFsplhsAa+LPKpTcEE+ttRptslQcAl+pAspVPlplAcpshchlplhptluphGNtsslSDssVushhscAAlpuAhlNVpINLs....sl...cDppahpchppchpplh	.............olpcFlctluScsPsPGG...GosuAlsuAlGsALssMVupLTl...GK..+p.Ytp.hcp...................phpplhpp.s....p.plpp....cL....lphlDcDscAFstlhsAaclPK...pT-....EEK.stRppslQ....p.uhcp.AspVPhplsctshcshpl.hpphsppGNpsulSDsuVushhhcuulpuAhlNVhINLs....ul...+D.cpaspphppchpplh......................	0	116	171	202
+2612	PF01268	FTHFS		Formate--tetrahydrofolate ligase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.70	0.70	-6.53	141	4825	2012-10-05 12:31:08	2003-04-07 12:59:11	14	10	2767	19	740	4276	2739	447.70	51	94.46	CHANGED	hhSDIEIAppsp..hcPIpclAp.cl.Gltp--..l-.YG+aKAKlshs.hlc..pl...ps+..............sGKLlLVTAIoPTPuGEGKTTTTlGLupAL.s+l......GKcshlsLREPSLGPsFGlKGGAAGGGYuQVlPME-lNLHFTGDhHAITuApNLLAAhIDN+lapsN.p......................................................LsIDscpIsW+RVlDhNDRuLRpIslGL...Gupt..sGhsREsGFDITVASElMAILCLusD......LpDL+cRlG+IlVuas....hcspPVTAcDLtssGAhssLLKDAI+PNLVQTLEsTPAhlHGGPFANIAHGsNSllAT+hALKLuD...............YVVTEAGFGADLGuEKFhsIKCRhuG.LpPcAlVlVATlRALKhHG....Gl.shss...............LspENl-ALccGh.sNLp+HIcNlpp.aGlPVVVAIN+FsoDT-uElphlcchs..p.ph.Gsp.sslspsWuc..GGcGuh-LActVlcs......pppsu.p.........FchLYssch.slc-KIpsIApclYGAssVphospAccplpphcchG.ascLPlChAKTQYSlScDPslhGsPpGFslslR-l+lusGAGFlVslsGclMTMPGLP+pPAA.sIDls.-sGpIsGLF	...............................................................................................................................................................................................................................................................................thoGDhH...AIsuANNLLAAh.lDNHIaQGN..p.......................................................LsIDs+c...IhW+R............s.lDhNDRtLRplssGL......Guph..............sG..h.sRE................DGFDITVASElMAILCLuss......lpDLKcRLu+IlluYs......h......c.s......p....PVT..spDLpspGAhssLLKDAlKPNLVQTLE..sTPAhlHGGPFANIAHGCNSllAT+hAL+.Lu.D...............YsVTEAG.F.GADLGAEK.FhDI.KCRhuG.lp.PsAVV.......lVATlRAL...KhpG....Gl....s+sp.....................L.sp.ENl-Al.cpGh.sNLt+HlcNl.pp.aGlPsVVAIN.pFs.o....DT-AEl..phlc......chspph....G....sp....sslspsWucG..GcGuhcLAc.pVlchh..........p.p....s....s...................FphlY...c.....c..h....slc-KIctIspc.lYG..A..ssVphss...p......A.p.cpltp....hp....p........G..asphPlshuKT.h..................................................................................................................................	0	264	454	610
+2613	PF03239	FTR1		Iron permease FTR1 family	Bateman A	anon	Pfam-B_3227 (release 6.5)	Family	\N	22.50	22.50	22.70	22.50	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.92	0.70	-5.47	13	2689	2012-10-03 03:33:39	2003-04-07 12:59:11	9	11	1826	0	661	2163	330	227.80	21	69.51	CHANGED	hhuhhllshREuLEAulllollluhlKp........................................................................stccppt.................t.lahGhhhulhhululGsuhhthhtultt.......hpc-lhEuhhShlAslllohMhhaMt+...up+l+sclctplspslt..................t.paulhlhsF......lsVlREGlEsVLFluuhsttss........ssshlusssGhhsuslluhhlapsuh+lsLptFhhhsoslLhhluAGLhuhu....hhthhchspt.pGhchhthspussshshsh.ushthshhssthsu.....llhslhGahsp..........hhhlhlllhluhhhht..hshthh	............................................................................................................................................................................................................................................................................................................................................................................................................t..h...h....ht..hh..h...h.t......................ht...t..hpt.........th....h..................................................................................................................................................t....t..h......hu....l..h...h...h...s.F.........................lsl...hREGlEs.llF.lhulhttts.............thhhh.hGs.hh.G...lh...s...u....h....l....l...u...h.l..l.h....h....s....s.....h..c....l....s....h.t....t.....h....h..h.hsuh..hl....hhlussLhutu..........hhthhp.t..s....h.......h.....p..h.............t.s........h..h.....p..t..s.h......hh.......................................................................................hh........................................................................	1	181	389	559
+2614	PF02491	SHS2_FTSA	FtsA;	SHS2 domain inserted in FTSA	Anantharaman V	anon	Manual	Domain	FtsA is essential for bacterial cell division, and co-localises to  the septal ring with FtsZ. The SHS2 domain is inserted in to the RNAseH fold of FtsA [2], and is involved in protein-protein  interaction [1].	25.40	25.40	25.60	25.60	24.90	25.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.50	0.72	-4.09	50	3487	2012-10-02 11:08:51	2003-04-07 12:59:11	15	8	3448	5	697	1941	882	80.40	34	18.91	CHANGED	uGsplpshsspGhls..hpscEVsppDlcRVlcsApshshss...-pcILHslPpcasl.DspcGI.+-PlGMsGsRLcscsHllTs	........................Gtplps.sspGhls........hpscElo.ppDlcpV.lcs.A.p.s.h.s.lss.......-ccll+.llPp-ahl.Ds.p..c.G.I..+-P..lGM.G.l.RLcscsallTs............	0	222	434	570
+2615	PF01580	FtsK_SpoIIIE		FtsK/SpoIIIE family	Bashton M, Bateman A	anon	Pfam-B_458 (release 4.1)	Family	FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids [1], termed the FtsK/SpoIIIE family.  This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli Swiss:P46889 and the stage III sporulation protein E SpoIIIE Swiss:P21458 which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification [1]. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.18	0.71	-4.85	23	9858	2012-10-05 12:31:08	2003-04-07 12:59:11	13	40	4316	14	1937	10212	3173	196.90	29	27.52	CHANGED	pltphhsspthctstsphslshGtph.tspslhh-lschP........HhLlsGuoGSGKSsslpsllhSlhhptpPpcVclhhlDsKhs.cLsshpslsHlhs....slsscsccshpsLctllsEMccRh..plhpphslcslst.....hppphsp..ht...................................................hs.lllllDEhs-Lhhssspc........lpshlsRluph......uR.....usGlHLllAs....................QRsus	.............................................................................h...............t...t.....l....lsl..Gpsh...t....spslhh.D..L.s..c.hP............................HlLl..AGs.T....G.SGKSs.h..l.p.s.llhS..l..l..h..p...t...p...P..........c...c.........l....+...h..h.h.....l.D......P..K............h........s....-........L.......s..s.......a.....p........s.......l........P.Hl...hs...................sl.s...s..-...s...c..c....u....s....p..s.Lp...h...h....s...s.E.M...c...c...Rh........clh....s.p..h......s..s.+.s.lst.............asp..t...h..t..p.............................................................................................................................................................................................................................hPhlllllD.E...h.u-.L...h........h...s...s...s...pc.........................lpp...h...l..t+....l.uph...........uR.......us...GlHl.llAT......QRPs...........................................................................................................................................................................................................................................................................................	0	624	1301	1668
+2616	PF04999	FtsL		Cell division protein FtsL	Bateman A	anon	COG3116	Family	In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein Pfam:PF04977 [3], however this interaction may be indirect [4].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.04	0.72	-4.27	66	1462	2012-10-02 13:28:50	2003-04-07 12:59:11	8	3	1456	0	307	877	315	93.00	37	83.99	CHANGED	Ls...thlhtsl.th.plhll....LhlhllhoAluVlassHpsRphhsp....hpphhpc+-pL-hEWtpLlLEpsshup+uRlEplApccLsM...phPssscplllp.	.......................................h.........h...s+lslh....Lhlsll..lo..A.ls..VV..h...s..s..H....p..oR..hLh..s.p.......h-ph....h.hE+....-tL....-h.E.WcpL..lLEcsuLu.c..HS.R.VEplApcc.LpM...ppscsuppsllh.t.....................	0	85	172	247
+2617	PF03799	FtsQ		Cell division protein FtsQ	Finn RD	anon	Pfam-B_1605 (release 7.0)	Family	FtsQ is one of several cell division proteins.  FtsQ interacts with other Fts proteins, reviewed in [1].  The precise function of FtsQ is unknown.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.26	0.71	-10.49	0.71	-3.91	180	3219	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	3193	6	616	2021	863	117.40	20	39.22	CHANGED	lAhWpp..s.t..tllsppGplhts..................phs..t.s.sLPhlhG........ssspp.h.......hphhpph.th.ss.lthplsslphsspps....WplhL...s.....s.Ghp.lhLsps.......s..htp...............+lpphsplhtph............t.......pp.........lth..lDlR	.........................................................lAhhps..p....thl.spsGpshss...................shs...phs..shP..h..l..h.G....................................pss.p.p.l...............hphh.pp..h.s....ph..sp....l....p.....hp..lpplshsspcs.............hpLhh.........s.............s...Gh...p..lhlsps................s....htc.................+.lthas.pl..h.pl..............t...tp.........lth.lDh....................................	1	173	372	497
+2618	PF01098	FTSW_RODA_SPOVE		Cell cycle protein	Finn RD, Bateman A	anon	Prosite	Family	This entry includes the following members;    FtsW, RodA, SpoVE	20.10	20.10	20.40	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.25	0.70	-5.67	15	10114	2012-10-02 17:14:55	2003-04-07 12:59:11	14	11	4374	0	2079	6986	6687	345.20	28	90.11	CHANGED	hpLlhhlhhLhs.hGllhlaSASshpuhshhsss.hhhhh+QllahllGhllhhlhhplshp..hhp+hthhhallsllLLhllhl....lGssssGA+RWlslG..slslQPSEhsKlulhlalAphlupt............t..hpsphcshhhsll.hhhlhsslllhQPDLGTulllshhhhsllahuGhsh.phhlsllh......lulsshlhh....lhhcsY....phpRltuaLsPapDPh.....GsGYQlhQSlhAluoGGlhGpGlGpupQ.KhtYLPEupTDFIFAlluEEhGhlGsllllhLahllhh+uhpIAh+...spcpFtpllAsGlslhlhlQshlNIGhssGllPlTGlsLPalSYGGSSllshhsshGlLhsluppppt	............................................................................................................h...hhhhhllh..lG.llh..l...h..S..u...o.....h................s..............t..........h....h.........t..........t................h......h......h...h....+...Q.hha.h...h....l..u..h.l...h.....h...h..l...h...h...h.l....s..hc................hh..p..p..h......s..h....h..h...h...h...........h.....s...l...l..l...L...l........h.......l...h.h..................hG...t.t.....s..p.....G.........A......p.......p............Wls..l.G......sh..s..h.QPSE.h.hKl.sll.l.h....l..A....t.h...lsc.....................................p......h..h..s....p....h.......p....s......h......h....h....h.....hh.........l........h.h....l....s..h.h..L..l.....h..h..Q...P.....D.....L..G..o...s..l.l....l....h...s...h.....hh........s....h....l......a.........l.....u.........G....h.....s.......h.....p........h....h..h.....s.....hhs..................hh.s..h.s..s..h..lhh..................................................hhhp...sY.......................p..hpRlh..s..a......l...s.....P....h....p...c..s............................usG.Y....Q.l.hp.S..hhA..lG.s....G.G..lhG..p...G....h.....s.....p.......ut..........p.....p.....h.....t...a....L..P...E........s..cTDFIFulluEEhG.h.l.Gshhll.hLahhllhR.s.h...h...l...uhc............sps.......F..sp..h.lusGl.......shhh...hhpshlNlGhs..hGl..l.P.l.sGls.LPhlSYGGSSllshhhulGlllslstpt..t............................................................................	1	736	1429	1800
+2619	PF03867	FTZ		Fushi tarazu (FTZ), N-terminal region	Finn RD	anon	DOMO:DM07486;	Family	This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represents a category of LXXLL motif-dependent co-activators for nuclear receptors.	25.00	25.00	28.60	27.10	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.01	0.70	-5.15	3	27	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	17	1	8	31	0	259.90	70	61.39	CHANGED	MATTNSQSHY.YAD..NMYNMYH...sHSLPPTYYDNSuSsSuYQsTuptWQ..PASYQSNYtAaYu.QESYSESCYYANspaQ.............PTssTVPQ.PsVPThPEPlltsS...PVKupKRKAEDsAAuIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTlEpVKKuP...PupoKuouSPAPSYEQEYVAVPTP...........SASEDVDYLDVYSPQSQsp+.KNGDFl..TPPPhATTPsossuI.EGISTPPQSPGEKSuoA..VSpEINHRIVTAANS..AuDFNWSHIEETLA	....................................................MAsTNSpSH.Y.Y..AD..NMYNMYH.....sHSL.PP....T..YYDNSuS..suhYQs....S.........uoYQ.SYtu.hYs.QESYSESCYYhNsQcQ............................p.stT.VP..Ps.Pss.......P.P...............KupKRKAE.....EsAAuIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTlEpVKKuP...sspoKsAuSPAPSYEQ...EYVsVPTP...........SASEDVDYLDVYSPQSQ......sp+....KNGDFs..TPPP..TTPs........ohssl...EGISTPPQSPGEKSuoA...VSpEINHRIVTAsNu...AuDFNWSHIEETLA........	0	2	2	5
+2620	PF02952	Fucose_iso_C	fucose_iso_C; 	L-fucose isomerase, C-terminal domain	Griffiths-Jones SR	anon	Pfam-B_9303 (Release 8.0)	Domain	\N	28.90	28.90	28.90	29.00	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.78	0.71	-4.68	45	1454	2012-10-02 11:40:13	2003-04-07 12:59:11	12	4	1208	15	185	864	123	155.10	38	29.63	CHANGED	ppshlhLhpsGsss......t.................pphptshptsphhstsppahpGu....shuophtphsssslThhRLs..cs.G.l.hhlucGpsl-hspc..spsplshpss.phspsaht..hs.p.........plhsshhuNHsuhsaGchupsLhphs.phLtIshs.h+	.............................................t.pGhlcLhNSGussLsh......tttpttt.t........hW-lppp-spusLtsTc.assA.h+..cY.F.RGG...........GaS.o.pF..hT.pu...ssPhThsRlNhl+GlG...PV.LQIAEGho.l-..LPc.c..sact..L.s.p.R..Ts.s.sW.P..oTaFs.s.R.lsucssF..psVYsVMsNWGANHuslshGHlGADllTLA.uMLRIPVs.MH..................	0	82	141	159
+2622	PF02300	Fumarate_red_C		Fumarate reductase subunit C	Mian N, Bateman A	anon	Pfam-B_11568 (release 5.2)	Domain	Fumarate reductase is a membrane-bound flavoenzyme consisting of  four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hydrophobic subunit C.	22.50	22.50	22.70	22.60	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.80	0.71	-4.27	23	798	2012-10-03 07:11:12	2003-04-07 12:59:11	12	2	794	18	71	276	17	127.10	62	97.67	CHANGED	soKRKsYVRpMpssWWpKhsFY+hYMlREuTulsslWFslVLlaGlhuLsp....GssuassFlsFLQNPlVllLNlIuLhusLhHshTaFphsPKsh.sIhlKsc+lsspsIlpuLWAlTslVSllsLslshl	................hoKRKPYVRsMTuTWWKK.LPFYRFYMLREGTAVPAVWFSI.LIaGLFALKs...........GP...E...u...WtGFV.sFLQNPVlVIlNLITLAAALLHTKTWFELAPKAA.N.I.I.VKsEK...MGPEPIIKu.LWAVTsVsTlV.ILaVAL.h......................	0	8	27	50
+2623	PF02313	Fumarate_red_D		Fumarate reductase subunit D	Mian N, Bateman A	anon	Pfam-B_12414 (release 5.2)	Domain	Fumarate reductase is a membrane-bound flavoenzyme consisting of  four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hydrophobic subunit D.	25.00	25.00	28.90	28.90	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.46	0.71	-4.21	21	816	2012-10-03 07:11:12	2003-04-07 12:59:11	12	3	799	18	72	251	10	113.80	66	96.91	CHANGED	hspsPKRSsEPlaWuLFGAGGMlsAhlsPVlILllGlLlPLGlls.tshsacplhuFApoalG+lhlLlllhLPhWpuhHRlHHGh.HDLKlHh.ssuphla.YGhAslholls..hhhVhs	.....I.NsNPKRSDEPVFWGLFGAGGMWuAI...IA....PVhlLLV...GILLPLGL.h.P.uDAL.SYERVLAFAQSFIGR...lFLhLMIVLPLWCGLHRhHHAM.HD.LKIHV.P.A.GKWVF.YGLAAILTVVTlIGll.T.................	0	8	28	51
+2624	PF03630	Fumble		Fumble 	Finn RD	anon	Pfam-B_3299 (release 7.0)	Family	Fumble is required for cell division in Drosophila.  Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with  high similarity to the pantothenate kinases of A. nidulans and mouse[1]. A role of fumble in membrane synthesis has been proposed[1].	21.20	21.20	21.20	21.60	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.90	0.70	-5.59	11	1080	2012-10-02 23:34:14	2003-04-07 12:59:11	9	12	701	15	460	840	178	273.20	33	69.95	CHANGED	s+lulDIGGoLsKLVYassps.sspp.pp..t.h.p...............................tGRLpFlpFpTpcIsphlpah+p.............pshsp.phslpATGGGAaKFt-hh+cplsl..plp+.DEh-sLlpGlsFllp...sl.pEsFsap.sp-sE..h.....phs.tsshYPYLLVNIGSGVSIltVpGpspacRVuGoSLGGGTFhGLssLLTsspoF-EhL-hAp+GDsoslDhLVtDIYGsc..Yp+hGLsusslASSFG+sh.....pcsKp....................ppaspEDlu+SLLhsIoNNIGQIAhhpAhppslcRlaFsGsFlRspshoM+TLoYAlcFWSpGphpAhFL+HEGYhGAlGAFLpht	.........................................................................................................................................................................................................................................................................................................ts.p..hp..Fhp.....o.p......ph.p.p.....hl.phhpp..............................................................hlphTGGsA...hh.h.....tp....................h...s..h......th.h.sEh-.shh..................pGl.hl.p................E..............................................................................................p..hps.....hh.salllNlG.oG..........sS..llhl..p..u..p..s..p...h...cRVuGo..ulGGGThhGLspL........L..o.t.h.p.....s.a--hlp...hA.p........cG......DpsplDhh..VtD.IYuss................c....s..Lsu.shsA..S..sFG+sh..............pp..t...p.t.......................................................................thoppDlstullhhl................s..psIuplAh.hhAtpp......pl.ccllahG...shh+sp....h.hhchl..s...sahsh...............tthpshFlc..ctua.GAlGAhh...t............................................................................................	0	148	239	359
+2625	PF04930	FUN14		FUN14 family	Wood V, Bateman A	anon	Pfam-B_8237 (release 7.5)	Family	This family of short proteins are found in eukaryotes and some archaea.  Although the function of these proteins is not known they may contain transmembrane helices.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.22	0.72	-3.72	34	431	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	305	0	272	412	7	95.60	28	60.52	CHANGED	QlulGulsGassGashpKluKlshhslGssllhLphhpppGhIplsWpplpptlppstppst...................shhpphhshl..ts........................shsuuFsuGh.hlGht	........QlshGulsGhssGahhpKluKlsAhslGsuhllL.QhhsppGal....plsWp+.lpc.p.h.p.p..s..pppht...........................................................h.phhp..ph.hphlt.tsh..........................hsuuFhuGhhlGh.............................................	0	82	127	205
+2626	PF01475	FUR		Ferric uptake regulator family	Bateman A	anon	Prodom_2003 (release 99.1)	Family	This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes.  This family is also known as the FUR family.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.39	0.71	-4.18	24	9302	2012-10-04 14:01:12	2003-04-07 12:59:11	14	10	4091	22	2167	5940	4980	119.00	26	80.09	CHANGED	csGlKlT.pRhpILpllppscp...HhoAE-lYctlh..ccsspluLuTVYRsLphhcctGllpchphs.sucshaElsp...tcHHcHllChcCGclhEFpsspIEphppclsccpGa+lhsHplplY	.......................................t.tGl+h.T.pRhtl.L.c.l.l.hpp....pp.......H..hoA--laptlp...........p..p.........t...s..p..l...u....l....u............TVYRsLphh.t-tG.l.l.c.c...l..p..........hs.....s.......u.......p......s...h..a....-..........h....sp...............tc.p.......H......p.......H...........l.....l......Cpp....C.G......cl..h...-....h....p....s......s............l.....p....p.....h.t......p...p....l...t...t....p...h...uaplppppl.h...........................................................	0	737	1498	1892
+2627	PF00757	Furin-like		Furin-like cysteine rich region	Bateman A	anon	Bork P	Domain	\N	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.75	0.71	-12.75	0.71	-4.55	40	888	2012-10-02 14:20:19	2003-04-07 12:59:11	15	44	120	49	334	892	2	154.30	37	12.91	CHANGED	scpCs.........ssp.sp.......t.s..CWuss........cCQ..................plCsppCst..tCp.....ssscCCH.ppClGGC......ouPp.sosChAC+capp....sGpClspCPs................upYpF.GtpCV..cpCs............................ps.hlh.....csupClhpCPsuhpcst......ssstpCp.Cs.Gh.CPKlCp	...................................t.s...........t..t.Cp.ss...........tts..CWups........pCQ.........................tphCsp.pCst...pChh..............pss-C..CH.ppC.s.G.GC......oGPp...ss-C.l.AC+pF.c.......sG..sCh.....pp....CPs................u.+.Y..p....a...GspCV.....c.pCP...........................................pp..hlh.......csuuC...lpp.CPsshhcs...........sssttCp.sCs..G...C..P.KsC..............................	0	65	91	210
+2629	PF04632	FUSC		Fusaric acid resistance protein family	Mifsud W, Bateman A	anon	Pfam-B_5345 (release 7.5)	Family	This family includes a conserved region found in two proteins associated with fusaric acid resistance, Swiss:P24128 from Burkholderia cepacia[1] and Swiss:Q48403 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.	30.90	30.90	30.90	30.90	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	650	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.29	0.70	-12.94	0.70	-6.09	92	3210	2012-10-02 19:04:43	2003-04-07 12:59:11	7	8	1176	0	491	3624	82	530.20	21	92.95	CHANGED	phhaulKshhAuhLALalAhtlsLspPhWAhhTValV.upPhs........GhshuKuhaRllGTllGsssulsllshhsppPhLhhhulAlWlulCshhus.h......Rs..cuYuFhLAGYTssllulsuls..sP...ps.....lFshAlsRspEIslGIlCuslVusllh.P...ppsstsltsplpphhtshtphs..sssLssptssst.....................tttplhuclssl-shtstssa-ssphptpsttlptLpschhsll...............shhpultphhptlp...stsss..........ltsh..lpplss.............................ttt.tttht..............................tLhtpl.tshpstht............shtthhhtphhphLtphhpshpshpslppshtt............................................................tpsht..hsh+pDhhhAhhsulRssluhhhsuhhWlsouWsuGusslhhsulssslhustssPs...hshphhhGshhusshuhlhhahllPplss.FshLslsL.usshhhsuhhhspPphus.huhuhslhhshhlu.psshs..hshssahNsulAhllGhhhuslshtll.hPsssphttcRLhpshhpcls.phsptphst...tpt.......tatuphhD+ltpLhsth......ttstspcphhp.slssLclGpsllpLRcthtp..........hssshpts.lcphLpsls.......t..tst.ttt.tsssthhptlppshtthssptsttt...............................tphhssLhtlptsLhs.spsh	..............................................................................................................hhauh+hslAhhL.u....l....h..lu..h......h......h....p........l.....s......p..s......t........Wuhho.s...h..l...V..h.t..P..ts.....................Gslh..+uhhRlh..GTllGsh.s...u..l...l....l.....h...h...h......h.....h........p.....p....P....h........l............h.....l.l...h.h..u.h..h........h....u.h..C..s..a.l..u.t.....................pt....t.u......Ys..h...h.L..A....Gh.T.h.h...l.ls.hs.hhs...pP.....pt.................h.h..p..h.A.l..h.Rss-l..llGllsuhhhshl.h....P...........pps...t....pt...h...p....p...p...L....p.s...h...l.s....p...hh....p....hh.....p.hhpststpt.............................tthttl..htp....h....h...s...h..p.t....h.......t.s....s............h...-...s..........t....p.....h......p.......p...t.......s..........t.......t....l.......p......s......l......p...p....l...ph.h....................................ohh.s...p.h...h..h......p..h.........p....t.th.......................lpph..lppltp................................................stth.ht.p.ht............................................................................pl..hp.l.t..ttttt........................................hp...h..hh..t..p..h..h....hh.h...hh...tph.t.t..p.h....................................................................................................h...hs.thp....h..h.h...hh+shhshhhhhhh..hs.tW..s..h.shhhh.hslss....ths.s.sh....h..hhhshhh.h...huhlhhhhlhs.hpt.h........h.hh.l.s..h.h.h.h...hh.h..t.......p..s...hh.h.t.....hl..hh.h.....s.........hp.h...t..hhs.ps....hu.llGhhhuhhh.hhhl...hs......s.tht...hhtthhtth.....t.h.ph...................t.p.....th.sh.h.........h..h...........................t...h...................t..t....h.h.t...............................ht..h....hhtth............................................................................................................h........................................................................................................................................................................	0	86	207	348
+2630	PF00523	Fusion_gly	fusion_gly; 	Fusion glycoprotein F0	Finn RD	anon	Pfam-B_102 (release 1.0)	Family	\N	20.80	20.80	20.80	22.30	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	490	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.33	0.70	-6.43	12	7380	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	164	82	0	4285	0	200.40	38	89.01	CHANGED	IshstLpplGllssps+phtlhoshpopalVlcLhPsls.......spssCspsplspYpphLscLLpPlt-sLst.pp..ts.......sspRp+RFhGsllGthA...LGVAT..AAQITAulALscAppsttsItplKsSlpsTNcAVpplppuspplshAVpslQDalNsplsPulsphsCchtshplGlpLs....ahoELsolFusplsssu..sslolQALp.Lhuusls.llpshhssphshhpllpothlpGpllsls.pth.hslplslPslsphssshlhch.slShshp...spEhhhplPshlhspus.ltsastss.ChhsspshhCspssu.slssphppC...lpGshosCshohlhushhs+FhhspGsllANCh.uhhCpCsssstsIsQs.spulohIshppCshltlsshphplsp.pspsshhtshslhsu.slslpPlD.lSspLupssppLpsupphlccSsphLsslsstpsotsshlhhlllsslslllhll	..........h.............................hhlcl.s.............th.pt.lt.hpphlppl....tssltt.ptshp....................sstRptRhlGhllGuh............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2631	PF01621	Fusion_gly_K		Cell fusion glycoprotein K	Bateman A	anon	Pfam-B_1083 (release 4.1)	Family	This protein is probably an integral membrane bound glycoprotein that is involved in viral fusion with the host cell [1]. 	19.40	19.40	20.90	20.40	17.90	17.70	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.22	0.70	-5.40	11	89	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	40	0	1	73	0	275.70	43	99.05	CHANGED	hhsspst+lullsllouYhlhllWYss.tsphts..sClYAstshs...sssshsW....................ttaNsoLlYl...shsst..h.sshpshsshCRpsllstsshshhstssslcc+lRhVhtsRNChAYLWpspl+hlsluhhlYhsFlslRppRRMFGshRsss-hlSPssYoLNYAupllSsllL+ssYTKlsRLLsElshpRpuLScsFctDPloFhap+ssshsLlshElhl+luutslshsTlslsasPCuhlaPhal+IhsWlFVuslsslELlull.tscPsptuut........sssssspss..GltulCs...sCCusllSGlhlKslYlshlsssVllhl+YEpclQhpLFG	....h.hhhph.hh.hlhhhosashhhhaYss.hsp..p...ClYAshs.....sst..shhW......................hNpohlah..........sst....sshtshs..Cht.hlttp.hsh.s...shpp+lh.VhtshsChthlW.sphphhhhuhhlYhhFlhh+p.RpMFGshpsttchlsPstYhhNYsspllusshLthsYTKhschLCELSlpRpsLsphFcsDPloFLa++PululllssElhlRhsAhsLlluTshls+ssCAlsYPLalpIhTWsFVuhlulsELhhll...cpssA.csut.........susssscsp.......GhpGVCu...pCCShlLSGIsl+lhYlAllshhVlhhh+YEpplQhtLhs....	2	0	0	0
+2632	PF02663	FmdE	FwdE;	FmdE, Molybdenum formylmethanofuran dehydrogenase operon 	Bashton M, Bateman A	anon	COG2191	Domain	This entry represents the FmdE protein that is encode by the molybdenum formylmethanofuran dehydrogenase operon.  FmdE does not co-purify with the molybdenum isozyme that is formed by FmdC and FmdB [1].  The domain is typically found as a single copy, but is repeated in some sequence two to three times.  It is also common place to find this domain co-occurs with a zinc-beta ribbon domain, suggesting that is may bind nucleic acid and be involved in transcription regulation.	21.60	21.60	22.50	23.50	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.76	0.71	-4.25	188	431	2009-09-10 13:21:47	2003-04-07 12:59:11	9	12	244	4	258	430	25	131.40	25	54.33	CHANGED	pFHGHhCPGlslGh+hsphAhcpL....sh...t......p.........s....cplhslsEss.....s...........ChsDAlQhlsGCThG+..s...sLhhh............ch....GKhAhoh...hscps..sculRl.......h......hp.pthpth.....htth..p........................cppppth..ptlhphs..cclaphpt	........tFHGHhCPGlslGh+huphAhcpL....sh....s........p.................s......cclhslsEss..............s................ChsDAlQhlsGCThG+....u....sLhhp.............ch......GKhuhoh.........hs..cps......sculRl............h.....hcs..pthpth........ph.th..p....................p..pphh.p.hhphs.pphh....h...................................................	0	119	200	228
+2633	PF04186	FxsA		FxsA cytoplasmic membrane protein 	Mifsud W	anon	COG3030	Family	This is a bacterial family of cytoplasmic membrane proteins. It includes two transmembrane regions. The molecular function of FxsA is unknown, but in Escherichia coli its over-expression has been shown to alleviate the exclusion of phage T7 in those cells with an F plasmid.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.35	0.71	-4.50	136	1830	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1809	0	376	1109	1286	120.20	33	73.64	CHANGED	hl.lhlllP..llEIslllpVGshIGhhsTlhLlllTullGshLlRpQGhpsltphppphp...pG.chPuppll.....-.GhhlhluGlLLlhPGFlTDhlG.llLLlPssRphl.tth....ltp+hph...........ts...s.ht	...................................hhhhlhshlE...IslhItVu.p.....hlG.s.h.h...TlhLllhTullGh.Ll.R.s.QGhps..hhphppch.s......tG......c.............P.......u.t.phl............c.ul.hlhlAGl.LLllP.GFhTDhlG.lLL.L.l.Pss.pphl.phh........lh.pht.........tth.tthh......................	0	104	230	311
+2634	PF04799	Fzo_mitofusin	fzo_mitofusin; 	fzo-like conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6217 (release 7.5)	Family	Family of putative transmembrane GTPase.  The fzo protein is a mediator of mitochondrial fusion [1]. This conserved region is also found in the  human mitofusin protein [2].	23.70	23.70	23.80	25.60	23.50	22.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.02	0.71	-4.88	11	189	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	95	1	101	193	1	163.20	50	23.86	CHANGED	hsshspsshopE-hhlshVsulASlTSRoShGlllVGGVlWKolGWRlIsluhulYGsLYlYERLoWTT+AKERuFKpQFVcaAocKLphIVShTSuNCSHQVQQELuoTFARLCpQVDsTppsLp-EltcLspcIppLEslQspuKlLRNKAshlpsELppFpcsa.Lpts	..................................................hs.sshoQEEhMl..ohlouL.ASL..T..SRTS..MGllVVGG...VlWKsVGWRLIulShulYGhLYlYERLTWTT+AKERAFKcQFVpaAoEKLQhIV.ShTuuNCSHQVQQELusTFA+LCQQVDlTpcpLEpEIsplsccI-hL-slQspuKlLR....NKAshL-sELp.Fscpa.Lp..s...............................................	0	28	36	66
+2635	PF01125	G10		G10 protein	Finn RD, Bateman A	anon	Prosite	Domain	\N	23.80	23.80	25.10	25.10	19.90	21.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.99	0.71	-4.64	28	378	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	308	0	261	313	4	138.50	57	91.64	CHANGED	MP+I+p.pp..+tPP-Ga-cIcsoLpcasp+M..................+-Apsps...tc..sc...............p+sEs.........hW.IaplpHpRSRYlY-haY+++...tIS+ELY-allcppYADssLIAKW+KpGYE+LCCL+CIQss-ssau.............................sTCICRVP+upLcps........phlpCspCGC+GCuS	.................MP+l+pt.p..KsPP-Ga-hIEsTLpEhppKM.....................................R-AE......s-s...H-...GK...................+KsEs..........LWPIF+IpHQ+SRYIYDLaY++K...AIS+ELY-ahl+psYADtsLIAKWKK...pGYEp.LCCLRCIQT+-oNFu.............................osCIC.RVPKupLcts.........phl.pC....lpCGCRGCu...............................	0	89	141	212
+2636	PF00503	G-alpha		G-protein alpha subunit	Finn RD, Anantharaman V	anon	Anantharaman V	Domain	G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring  of residues centered on the nucleotide binding site [3]. A Ggamma is  found fused to an inactive Galpha in the Dictyostelium protein gbqA  [3].	48.80	48.80	48.80	48.90	48.70	48.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.31	0.70	-5.78	134	2902	2012-10-05 12:31:08	2003-04-07 12:59:11	15	23	511	117	1599	2617	11	305.60	39	89.11	CHANGED	Mushh.......................................................................................ptpppttppps.p.ph.p.c.p.h.p.pc.ppptp.................pplKlLLLGsGESGKSTlhKQh+llatssas........................pp.EpppapsllhpNllpuhptllcuhpphphsht................................................................................................................................t.ppppptphlhphtsthtp.............................................................................................................................hstchspslppLWp.Dsslppsap..+ppchpL...................tDsspY.................Flsslc........Rlspss..YhPop..................pDlL+sR.l............................pTsGIhEhpFph......................pphpa+hhDVGGQ.RoER+K.WlphF-..................................sVsullFlsuLS-YDpsLhEDpps......................................NRhpESlpLFcsIsssphFp.......sssllLFLNKhDlhccKlpps...lpphFscap............................Gs..sshcp.stpalpppFhphsppp.p........................+plYsH............hTsAs..DTpslphl...hsslp-hI	.............................................................................................................................................................................................................................................................................................t..st..h.p.p.l.p...tp..t...t..........................................................................pth..Kl.L.L.L...........G..s..........GE....S...GKST.......h..lK.........Q..M..+.........Il..H.t..s.G.as...............................pc.-....ttp.ap.hl........hpNhhp..u..h..hsllcAhpplth.ht.....................................................................................................................................p.tpt..psp..l.hth...s.t...t..............................................................................................................................................................................................................................................hs.chht..sl..p...pLW..p.Ds.Gl..p.tsap...R....ppEapL.............................................DsAtY......................................aL..ss..l-........Rl..s.t.s.s..YhP..op......................pDlLRsR..l............................hToGIh..Eh.pFph...........................................................................pplpa.+hhDVG.GQ..RS.....E...R+K..WI..HC.F.-..................................sV.Tu.I.lFhl.......AlS.p..Y.D..s.L..hE...D..p..pt.................................................................................................................................NRhp...EShtLFcoIh..N.s.caFt.......po.SlIL.......FL.NKhDlhpE..Klht..s.....lpth.F..P-Yp........................................Gs..pshpp...Atta.l.....hppF..phsppp.t........................+.lYsH......hTsAs..DTpslphV..FssVpDhI................................................................................................................................................	0	558	822	1230
+2637	PF00631	G-gamma	G_protein_gamma; 	GGL domain	Bateman A, Ananthraman V	anon	Ananthraman V	Domain	G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins [1]. It is also found fused to an inactive  Galpha in the Dictyostelium protein gbqA [2]. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta [2]. All organisms that posses a G-beta possess a G-gamma [2].	22.30	22.30	22.60	22.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.37	0.72	-4.23	50	1212	2009-09-12 06:39:52	2003-04-07 12:59:11	17	17	266	24	681	1015	0	65.80	28	29.38	CHANGED	sphphphtpEl.ppL+p-Lpc..pRl.plSc..AstsllsYsp..sscDshlsss......s.ttpNPatpp..............tss.Chlh	.......................t.....thpcpl.ppL+hclsh..pRl.KlSc...........uut....s....LhsYs-p.....hsppDPllsss.......s.tt.NPahpc....................tts.Ch.........................	0	129	220	399
+2638	PF04466	Terminase_3	G2P; 	Phage terminase large subunit	Waterfield DI, Finn RD	anon	COG1783	Family	Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit.  This region is found on the large subunit and possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction.  This region is also found in bacterial sequences [1,2].	22.40	22.40	22.40	22.40	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.22	0.70	-5.38	10	1027	2012-10-05 12:31:08	2003-04-07 12:59:11	8	7	859	2	119	1203	485	355.30	23	85.08	CHANGED	s+papVhhGGRGSuKShslAhplVl+h....hpp...stssLl.lRcltNTlccSlasplp-slspLslschF+hs+Sslpl.phssGup..FhFpGh.DcPtKlKSlc....slsslWlEEAuphpp-s.acpLlsolR......c.thclahSaN.PhscpsWla+pFh..........Dspth........sDshlc+STYpDN...FLscshlcphE-hK+....pNschYRhhhLGEhsssGstlhs...lcshplpssp.tthphshth...........DhGapscssuhlphulch++phlalhs-ahp......sthlccpsu-hl+-.........tphp+cshpu-usEs+ultshcpp.......................thh+hhsu++upsohhpts+hlcpa+sllt..................pscspphIpEhpphpappDcpus.hs....c.hctD.....sHslDAlhYAlcc	..............................................................................................................t...hhlhhGG.RGSuKSh.s....h.uhhh..lhth......hp................s.h.t...hlh..h...RchtsolccSs.app.l.c..sl.p.p...h...u......l....p..c..........h..a..c.h.sp.o..h.c...h..hhss...Gsp.....h.l.FpG.....h....c.........s...s...p..+l..KShp.........sls..hhWh.EEA.....pp..h....pp.ps....aptlh.olR...................p.h....tp....l...a.h.oa...N.P.h.pp...ts..al.cpa.h.............................................................................psshl.hp...ssY....p..DN............a.lsc....hh.p.p.h.-.p.h.p.p................ps.sph.Y.+..h..hh.Gch.h.s.s..ss.h.s..h.................h..pt......h..pt..t........t..t..h..p....h..h.th......................................Dh....G.as....p...c.ss.uh.h..p..h.h...l................p...p.ptl...a..l.....p.-h.h.t...........................th......p...p..t.h..sp.hlhp...........................................................th..t.pt.......hh.uct..s..p......c.ht.thcp....................................hhph.hsspK.s..s..s.h..s.........p....h......l...p.t....h......chll................................ps.phhpEhpph.paphD.pt.s.p..h.........cp.p.........sHhhDAhhYsh..................................................................................................................................................................................................................	0	34	78	95
+2639	PF04309	G3P_antiterm		Glycerol-3-phosphate responsive antiterminator	Waterfield DI, Finn RD	anon	COG1954	Family	Intracellular glycerol is usually converted to glycerol-3-phosphate in an  ATP-requiring phosphorylation reaction catalysed by glycerol kinase (GlpK) glycerol-3-phosphate activates the antiterminator GlpP [1].	21.20	21.20	21.20	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.11	0.71	-5.23	8	1079	2012-10-03 05:58:16	2003-04-07 12:59:11	7	1	949	12	137	527	4	171.60	41	93.62	CHANGED	PllsAl+shcpl-chl-S-hphlhLLsuclssl+pll+hlKs+sKpsFlHlDLlpGLspc.EhuhcFIppthcsDGIISTKuplltpAKKpslhsIQRlFllDSpALcpuhcpltphcPDhlEVLPG.lhP+lIccIsc+oshslIAGGLlcTcEEVcpAL+uGAsAVS.............TSpc..cLWc	..............................................................sllsAl+s.c.sLct.hl.c..o..c.h...ph.lslL..spIsplpsllchl.KpsuKhsFlHlDLlcG.lusc.Ehulpalpp.hcsc.GIISTKushl+pA+phuhh.sIpRlFllDS.uhcpuhc......lpp..sp..PDhlElLPG.sh.P...+.l.lpp...lp..c.ch.p...hP.l..IAGGLIpsc--lppAlpuGAsAloTSppplW.....................	0	64	97	119
+2640	PF00479	G6PD_N	G6PD; 	Glucose-6-phosphate dehydrogenase, NAD binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.70	21.70	22.50	22.30	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.08	0.71	-4.05	117	4951	2012-10-10 17:06:42	2003-04-07 12:59:11	17	21	3884	29	1192	3729	762	172.30	37	36.68	CHANGED	llFGAoGDLA++KLhPALapLhppGhLsps.hpllGhARpcho.c--a+phlcpslpp..........tpphsppthcpFhp+lpYhssshs.sspuappLpptlpch-p....t.ttssplFYLAlPPshFsslsppLppssls..ttp......hsRlllEKPFG+DLpSAcpLscpltphFcEcQIYRIDHYLGKEhVQN	.........................................................llFGuoGDLA+RKLhPuLapLh.p.p.G.h.L.......s.p.p...htll..Gh..u..R..p.c..h.s.....c...-.p..app...h.l.cp.u...lpp....................p..t.h.sppthcpFhp+h..pY.hsh.-.h......s..c...s.p.s.....app.......Ltphlsph....pp..................t.......t................splFYLAhsP.shFsslsppLppss..Ls..........ptp.t.............hsRlllEKPFGpDLtSApcLNsplt.phF..cEcQl...........a.R.IDHYLGKEhVQN...................................	0	344	698	973
+2641	PF02781	G6PD_C		Glucose-6-phosphate dehydrogenase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.50	19.50	19.60	19.60	19.00	19.40	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.96	0.70	-5.56	11	5312	2009-09-10 19:48:29	2003-04-07 12:59:11	11	20	3976	29	1208	3992	928	265.50	41	59.39	CHANGED	LsLRFuNplFsshWNRcsIssVpITF+EsFGTEGRGGYFDphGIIRDlhQNHLLQlLsLlAME+PsShss-sIRDEKVKVL+ulcslssc-V....VLGQYsuu.sGs....ptGYl-DsTVspsSpTsTFsAhhlcIcNERW-GVPFhlRsGKALsp+KuElRlQFKsVstslFcpp...htcNELVIRlQPsEAlYhKhhsKpPGls...hssppo-LDLTYucRa.pshhlP-AYERLILDshpGspspFVRsDELctAW+hFTPlLctl-.scps+PhsY.hGS+GPptuDchhpcsGasascs	................................slRF.AN.s.lFcslW.NppaIcpVQI.............ThuEplGl.E.sRuG.YYDp..s.Gsl..R.DMlQNHlL.................Q..lLs.llA..ME..Ps...s...h....s....s.-....s....lRsEKl.................K..........VL+u..lc....h....s.....t..p.s.l...........hV...RGQY....t..u...Gh............................tu................t......h.uYh-E.....s....l....s.......s.Ss.TE.TFsAh+h.I-NhRWs...GVPFYlRTGKRLsp+s.oclsl.FK.p...s....s....h....s...l.F....tps................hs.Nh....LsIc.....l.Q..P.sE....Glplp..h.....t.....s...K.......P.G..s..................hp..h..p...sp.L-.......h.....s.......h....s.pp................t..........p..h.....p.........s..-....AYE+LlhDshpGstshFs.+.......tDEl.ctuWchlsslhchWt....t.........s.........t....s........................s..Ytu.....Go..........h.GP.tu.thl.t+p.GhtW..h..............................	0	350	709	987
+2642	PF01468	GA		GA module	Bateman A, Finn RD	anon	Pfam-B_895 (release 4.0)	Domain	The GA (protein G-related Albumin-binding) module is composed of three alpha helices [1]. This module is found in a range of bacterial cell surface proteins. The GA module from Swiss:Q51911 shows a strong affinity for albumin.	24.10	24.10	24.10	24.10	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.86	0.72	-3.82	102	9090	2009-01-15 18:05:59	2003-04-07 12:59:11	12	216	256	15	122	9161	0	59.70	37	28.26	CHANGED	lssucssLsGsppLtpAKpsAppplssLspLNssQ+sshpspIssAsolssVsslpspAp	................................VssuKsALN..G.s..p.p....LspA..K..psA.p.p.sls.sLspLNsAQKs.sLpsQIspAs..slssVsslppsAp..........................	0	58	62	119
+2643	PF02938	GAD		GAD domain	Aravind L	anon	Aravind L	Domain	This domain is found in some members of the GatB and aspartyl tRNA synthetases.	21.10	21.10	21.10	21.70	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-10.04	0.72	-3.83	24	4662	2012-10-01 21:10:01	2003-04-07 12:59:11	9	15	4517	16	1094	3469	2015	96.00	34	16.26	CHANGED	Fpsshtp..sGpV+AlplPs..sshoR+pIcthp...chuppaGApGLsal+lps.....tthpuslsKa...lsEpphpplh-pssApsG.DhllhsAsp.tphsspuL	............................Fttshps..tGpVtAlsl...s...Gu......s...phoR.Kp.lDp.hs......ca.s.p..t.a...G..AKGL..A..a.l...KV.s-............ssl...p..u.PlAKF.........l...s.p....-..t......h..ps......lhc......ps..s....A......ps........G..DllhF.sADp.tcllspsh.......................	0	359	705	913
+2644	PF02337	Gag_p10		Retroviral GAG p10 protein	Bashton M, Bateman A	anon	Pfam-B_959 (release 5.2)	Family	This family consists of various retroviral GAG (core) polyproteins and  encompasses the p10 region producing the p10 protein upon proteolytic  cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope  glycoproteins in most mammalian retroviruses and may be involved in  virus particle assembly, transport and budding [1]. Some of the GAG polyproteins have alternate cleavage sites leading to  the production of alternative and longer cleavage products (e.g. p19  Swiss:P21411) the alignment of this family only covers the approximately  N-terminal (GAG) 100 amino acid region of homology to p10.	19.60	19.60	19.60	21.50	18.50	16.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.96	0.72	-4.24	5	102	2012-10-01 20:35:47	2003-04-07 12:59:11	12	13	32	2	27	135	0	88.40	37	14.18	CHANGED	MGSopSc.pLFVotLpcsLKpRGl+V+cscLlsFasFlc+VCPWFPpEGolslcsW+RVG-plccYYspHGPEcIPlsTauaWsLIRDlL-	.................GpphSp...alphLphhLp...pRGlpVppssLlpFhphlccssPWFPcEG.T.lsLcsW++VGcpl+pahsh+Gs-pIPlpsashWsll+-hLp..................	0	11	11	11
+2645	PF00540	Gag_p17	gag_p17; 	gag gene protein p17 (matrix protein)	Bateman A	anon	SCOP	Domain	The matrix protein forms an icosahedral shell associated with the inner membrane of the mature immunodeficiency virus.	20.80	10.00	20.80	16.00	20.30	9.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.74	0.71	-4.41	3	37754	2012-10-01 20:35:47	2003-04-07 12:59:11	13	30	106	33	0	27496	2	123.20	74	36.45	CHANGED	GARASVLoGGcLD+WEKIRLRPGGKKKYplKHLVWASRELERFAlcPGLLETcEGC+KILpQLpPuLpTGSEGLRSLYNTVAVLaCVHQ-IcVKDTcEALEpl+ccpscscKK..TtssssuuQQuAusGGTusSuGlSQNY	..........................GGc..LD.tWEKI...RL.RPGGK.K+Y+LKHlVWA.....S....R.ELERFAlNPG.L.LETo.EGC+QI...ltQ.L.QPuLQ.TGS..EE.L+SLaNTVATLY..C.V..HQ+I-VKD.TK.EALDKIEEEQ.N....KSKpK......................s...Q....Q...us...u..s............s..u...s..s...u...p...V.S.QNY......................................	0	0	0	0
+2646	PF02228	Gag_p19	gag_p19; 	Major core protein p19	Bateman A, Mian N	anon	Pfam-B_1307 (release 5.2)	Family	p19 is a component of the inner protein layer of the viral  nucleocapsid.	20.80	20.80	26.00	23.50	18.50	16.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.19	0.72	-3.68	2	75	2012-10-01 20:35:47	2003-04-07 12:59:11	11	10	18	1	0	77	0	83.90	64	15.89	CHANGED	MGphaSpsAsPIP+sP+GLAhHHWLNFLQAAYRLpPGPSpaDFHQL+KFLKlAlcTPshlsPINYSlLAuLlPKsYPGRVpEIltILIQpps	...MGphau.ssoPIP+sP+GLusHHWLNFLQAAYRLpPGPSsaDFHQL++FLKlALcTPlWlsPINYSlLASLlPKGYPGRVsEIlpILIQsQ..............................	1	0	0	0
+2647	PF00607	Gag_p24	gag_p24; 	gag gene protein p24 (core nucleocapsid protein)	Bateman A	anon	Bateman A	Family	p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus  replication both in vivo and in vitro.	20.70	19.70	20.70	19.70	20.60	19.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.36	0.70	-4.78	16	45086	2012-10-02 13:14:50	2003-04-07 12:59:11	15	80	305	153	68	32172	2	179.20	82	55.09	CHANGED	.+pLpthhpslcp.uhsustslshhpulupsh..sshDhpphLss..ss...sptus.hpll+st...lsEpstchcpsp..s..sshs........hss-.IhGsGs..spppptphths.....sltpphpphhltAhp+lsphtsss.shhsl+QGPcEPYpDFVsRLhpslcsp.sstcsKphhhcpLuhpNANs-Cpphl+slt....hpuoL.p-hlpACpslGustpKuplh	...................................................................................PRTLNAWVKVlEE.KAFSPEVIP.MFoA.L.SEGA...TPQDLNT.ML.NT..VG...GHQAA.MQMLK-T......INE..E......A.AE..WDR.lHPVH..AGPlAPGQ...MREPRGSD.IAGTTS....TLQEQIuWMTsN.....PPIPVG-IY.K.RWIILG...LNK...I..VRM.YSPs..SILDI+QGPKE.PFRD..YV.D.RFaKTLRA...E..Q.A....oQ-VK.N.W.M.T-TLLV.Q....N.A.NPDCKT.I....L+.A.LG....PuATL..EE.M..........................................................	0	11	11	17
+2648	PF02093	Gag_p30		Gag P30 core shell protein	Bateman A	anon	SwissProt	Family	According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly [1].	20.40	20.40	20.50	21.50	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.58	0.70	-5.12	6	261	2012-10-02 13:14:50	2003-04-07 12:59:11	11	22	75	32	46	311	2	181.30	63	26.71	CHANGED	QYWPFSuuDLYNWKopNPsFScDPsuLTuLIESlLhTHQPTWDDCQQLLQsLLToEERQRVLLEARKsV.GssGRPTQLPNEID-uFPLTRPcWDYsTAtGRE+L+lYRQhLLAGL+GAuRRPTNLAKV+pVsQGssEoPSAFLERLhEAYRhYTPaDP-sPGQpAsVuMSFIhQSAPDI+pKLQRLEGLQsaoLpDLVKEAEKlYNKRET	.........QYWPFSSSDLYNWKsNsP.sFSEDPtcLT.........uLlESlhhTHQPTWDDCQQLLtTL.hTsEE+pRlLLEARK.....sV.GsD.GRP..T..QLs..NE...l...stuFPLp.RP.sWDYs.T.scG.R.ppLhlYRQhLlAGL.psAuRpPTN.LAKV+tlhQGssEsPSsFLERLhEAaRRaTPaDPps.uQcss..Vuh..uFIhQSA.DIt+KLpRLEsLpptpLtDLV+EAE+la.+RET........................................................	0	4	4	12
+2649	PF03276	Gag_spuma		Spumavirus gag protein	Mifsud W	anon	Pfam-B_1878 (release 6.5)	Family	\N	19.60	19.60	19.90	19.90	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.99	0.70	-6.18	7	132	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	16	0	1	105	0	287.50	61	96.65	CHANGED	MAt.....p.-LDs.tL.sla.s.Gl.ppP.Ht-lIulRhTuG.WG.u-RaphVplhLQDs.sGQPLQ.Pcac..s.RssNPtsp..hlluuPaspLRpAFpsl-lucGs.RaGPLusGpa.PGDtYSppFpPls.pEhAQhptpcLEp............lshlthtchEIRhLRp.h.chph...tGhssslPsAsts.PP..s..t.....................................................................P.p....PsA..........hPsPshsPhl..sssP.....PhPssp....IPIpHIRAVhGpsPsNPR-lPhWLGRsssAI-GVaPhsssshRsRllNALluup.GLsLps.-ssoWsuAlAsLahRTaGuhslHpLusVLpuIAspEGVssAapLGhMhospsasLVWGIlRshLPGQAlVsshQpRLDt.ssDtsRhtsF.phlpsVYplLGLNs+GQSlp....hsposptps.uputGRGppu.csp..........pppppGRppspssptQpsp.ps.ssQp..Qppsssps.ptp.GGYsLRPps.QPQRYGuGpGpt.Ns.......pPhRpsspspspppps.s...sRG.sQScssussttpGGRtspsRNppuussssop	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................AIDGVFPlTTPDLRCRIINAlLGGNLGLSLTPuDClTWDSAVuTLFlRTHGpaPhHQLGsVlpGIsNQEGVATAYTLGMMLSGQNYsLVSGIIRGaLPGQAVVTAhQQRLDQElDDQARAETFIpHLNAVYEIL.GLNARGQSIR.....ASVT.sQPRP.SRG.RGRGQstsRPSp.........GPAsSGRGRQRPAs.GQ.-RGSNsQNQs..QuNsuQ................................................................................................uGh.................................	0	0	1	1
+2650	PF00337	Gal-bind_lectin		Galactoside-binding lectin	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family contains galactoside binding lectins.\	\	  The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	22.10	22.10	22.20	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.79	0.71	-4.81	80	2093	2012-10-02 19:29:29	2003-04-07 12:59:11	17	35	209	254	1005	1892	5	132.10	26	57.70	CHANGED	shhtsl.sssh.ps...GpplplpGhst..................sss...................spFplNltss............psslslHhNsRasp........sslVpNo..hhsus..Wu..p.EER...........................................................tshPFppGp..Fplplhsp.pcpaplhlNstphhpFtaR..hs...pplst.lplpG..Dlp.lpslph	............................................................l..su.l.ts...GpplhlpG.ps...................ss..............................................pp.Fplsltss..............ts-lAhHhNP.RFsp..................................stlVpNo...hhssp....WG..p..EER................................................................t.t.t.h.PF..p....p.Gps...F........c.......lp........lhs..p..pp.pap......l...hV.sG...pph...h...patHR.......hs.........pplstl.p....lpG...Dlp.lppl..h...................................................................	0	188	321	655
+2651	PF03902	Gal4_dimer		Gal4-like dimerisation domain	Finn RD	anon	DOMO:DM03802;	Family	\N	21.10	21.10	21.30	21.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.62	0.72	-4.03	4	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	49	6	40	99	0	49.00	39	7.09	CHANGED	TRAHLTEVEsRlupLEQlL+.lFPchDlDplLpp+cp.pl+tlLp.htsosslst.u	TRAHLTcVEsRLppLEplhtpLFP.s....t....-lDt....lL....p.....p..........................................	1	6	23	36
+2652	PF01762	Galactosyl_T		Galactosyltransferase	Bashton M, Bateman A	anon	Pfam-B_885 (release 4.2)	Family	This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferas e Swiss:O43825 [1] and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase  Swiss:O54904 [2].  Specific galactosyltransferases transfer galactose to GlcNAc terminal  chains in the synthesis of the lacto-series oligosaccharides types 1  and 2 [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.29	0.71	-4.71	14	2182	2012-10-03 05:28:31	2003-04-07 12:59:11	16	34	186	0	1505	2219	31	177.90	24	47.89	CHANGED	sRRsslRpTWhspp...h......sclptlFLlGhss.t-t+hcchlhpEu+.hYGDllhs-hpDsYpcLsaKoLshhhausopsPpschIsKlD-DVhh.sspLhshLtpt...hssp.psthYGhlh.psGhshtpcps+.............Wahs.psasssp..............assYsuG.hYllotcAsptlhpsoc+p.pahplEDshl.GlhApchslshhsh.	.......................................................................................pRpslRpTWhttt....t.....................................htl...h..h.hFl..............l....G....t..s....s..............................s............t............p............h..p...p..................l..p....t.Esp.ta.s.D.l..l.....h..s....a...h.D..s.Y.tN.L...o.h...Ks....lh............h...h.............pas....s....p.......h..............s..........s............t.........s..c....a.lhK.s............DDDs.al.sh.spl...lp...hLtph................................p...p...p...........h..........h.....h......u.......th.....h.......p........t....t......s..........h..p..p........t...s.K..............................a.a..h..s...p..a.......s.h..............................................Y.P.sa.s.s.G.............s................uYl.hStsls.p.h.l.....h....t.....s..s...........t.....p........h.....p.h...........h...........h........-D.Vhh.Ghhhtt.h.t.l......t......................................................................	0	563	798	1152
+2653	PF02709	Glyco_transf_7C	Galactosyl_T_2; Glyco_transf_2C;	N-terminal domain of galactosyltransferase	Bashton M, Bateman A	anon	Pfam-B_834 (release 5.5)	Family	This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.64	0.72	-4.51	98	1328	2012-10-03 05:28:31	2003-04-07 12:59:11	9	46	442	59	697	3197	601	76.40	28	20.10	CHANGED	pph..ssshsphphph.a.pphhGGlhuhppppahplNGas..NpaaGWGuE.DDDhhtRlhtpsh..p...............lpR....shshst.......a+hh....H.......p	...........................................h.h..tt..h.h.GGlhuls+pp.F..h..pl....N.Gas...spa.h...G.W.G.u.E.Ds-h.h.t...Rl.hh..s.G.h..p..........................lpR.....p.h.phst..........a+hh...H.tp..........................................................	0	242	317	501
+2654	PF01296	Galanin		Galanin	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.90	21.20	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-7.15	0.72	-4.11	4	94	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	41	0	35	88	0	24.10	73	25.87	CHANGED	GWTLNSAGYLLGPHAlDsHRSFsDKHGLA	..GWTLNSAGYLLGP+AlDsHRSh..tDK.Ghs......	0	2	5	10
+2655	PF02052	Gallidermin		Gallidermin	Mian N, Bateman A	anon	IPR001049	Family	\N	20.20	20.20	20.20	20.60	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.53	0.72	-3.84	3	129	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	89	1	5	51	1	45.90	56	90.42	CHANGED	MEAVKEKNDLFsLDVKVNAKESNDSGAEPRIASKFLCTPGCAKTGSFNSYCC	.........h-........clhDLDVpVKus..s.sNDSuuDp..R..ITS+SLCTPG.Ct..K..T..GSFNSaCC............	0	1	2	2
+2656	PF02744	GalP_UDP_tr_C	GalP_UDP_trans_C; 	Galactose-1-phosphate uridyl transferase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports fold duplication with N-terminal domain.  Both involved in Zn and Fe binding.	29.20	29.20	29.30	29.40	29.10	28.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.15	0.71	-4.71	9	2558	2012-10-01 23:45:21	2003-04-07 12:59:11	12	9	2265	12	565	1810	220	176.00	32	43.44	CHANGED	E.........cpa.cYhttp........GShLhhDYsp.......hEltct-RlVh.s-p.alsVVPaWAtWPapsLlLs.+c+lhpls-Lsst..........pppDLAu........hl+plsp+YDNLFE.........TSFPYSMGlHtushsspts...tth.hHsHaYPPLLRSATVRKFhV.GaElLupsQRDlssEQAAt+L+..........sLs.phHhchsh	...........................................................................th..c...tYFttp............GS.LhtDahQ...............................hE.hA....s....t..pRhlht.s.-...ahsVs.shhs.pWPhpslhLs..pp.c...hpcls-Ls-p.....................ppsslst................slp.lsp.+.h.D..s.h.F.p...............................sShsYshGh............................................................hH..sH..h..s...h.l.+.pt.s.lt..hh.V.G.h.t.h.L.s.tp....+.-.htE.us.hLp..................tls..thH.t...t..............................................................	0	171	324	461
+2657	PF01087	GalP_UDP_transf		Galactose-1-phosphate uridyl transferase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports fold duplication with C-terminal domain.  Both involved in Zn and Fe binding.	22.10	22.10	22.10	22.30	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.35	0.71	-4.23	135	2821	2012-10-01 23:45:21	2003-04-07 12:59:11	17	13	2385	22	659	2041	370	183.20	28	46.17	CHANGED	s.ths.p-p.......................................sphRhssLhuphll..............suscp.................tcR..satspppth.tsshsptD.......hshLsPssscl....ssp.hsspY..psshshsNcFhuLpp.csshhpp..........scs..................hapspsshG.phcVhh.tsc.p...............p-hcslsssh.tphtp.........p......................th.phl.saENcGhthus......o..HP.............................Hu.lasppalP	................................................................................s..h...Dp...sp.RhtsLh.Gphll...............................susct..........................tc+........sht.s...tp...tt....pp.h.s.sp-................shls........Ps......s.....s..........p.....l..............stp.....h..................ssY...........psshhhs...s......c............FhsLtpcs.s.ht.p....................................sps................................haps.pss.hG..phclhh.psc.p................pchcplsts...phsc.....h..p.....................................h.thl.saENcGhthG....s....o.......HP..................................Hu.lhsspalP..........................................	0	214	398	548
+2658	PF00304	Gamma-thionin		Gamma-thionin family	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.49	0.72	-3.95	50	545	2012-10-01 23:31:40	2003-04-07 12:59:11	15	2	132	17	121	592	0	46.80	35	59.18	CHANGED	+sCcstSppF.+GsChssss..CspsCpp..Esas...uGcCct...hpRR.ChCo+.C	................hCcs..Stpa...cG..s.C...h...s...sss..CsshCps........E...sas...uGpCph......pp+.CaCpt.C............	0	27	58	87
+2659	PF04410	Gar1		Gar1/Naf1 RNA binding region	Kerrison ND	anon	DOMO:DM04007;	Family	Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation [1]. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex [2]. In humans, Gar1 is also component of telomerase in vivo [3].  Naf1 is an essentail protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1 [4].	29.30	29.30	29.50	29.50	29.10	29.00	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.62	0.71	-4.77	57	687	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	360	15	496	691	25	146.10	25	42.52	CHANGED	sp.hhcthhst...shshs..ssspl..lGph.pss-sp....lllcusss.......pV.phsuhlh.hEs+s.l.GplsElhGslpsshasV+.......sppthpst..shphGsplahsss....hph.hhspshtt....+Gscuusttccchs..tttt.pauccctptth+pttptp+	...................................................................ttt....tth...h....t.h.p.s..sstp..l..h.lGph.p......hs.-.s.p....llscuhss..........pl..hsusla..h-...s.+.p...l.G+VsElhGslppsaaol+..................s-slpsp.....uh..p..hGsp.hYhssp....................hph.hhsp.hht.....................+Gsctut.ttstpss........tth.t.aus.sttt.tthtttht...t..................................................................................................	0	175	287	416
+2660	PF01071	GARS_A	GARS; 	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_916 (release 3.0)	Domain	Phosphoribosylglycinamide synthetase catalyses the second step in  the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin  carboxylase/carbamoyl phosphate synthetase (see Pfam:PF02786).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.14	0.71	-4.74	19	4769	2012-10-10 13:17:03	2003-04-07 12:59:11	14	45	4503	19	1247	7505	5005	188.90	49	41.23	CHANGED	uSKsFsKcFhp+asIPTA.pYcsFo..c.sccApualcctshss.....VVKAsGLAAGKGVlVs....psp-EAhpAlc-lhtpttFG.pAGcpVVlEEhL-G-ElSlhshsDGcolhshssAQDHKRlh-GDp...............................GsNTGGMGAYu....PsPhlopclhcplhcpIlpPTlcuhtcEGhsapGlLYuGlMlo.csG......PKVlEFNsRFGDPET	....................................................GSKsFuK-hM.t.+as..IP...TA...p..............Y....p..s..F...s........-......hc...p...A...h.....s..Y...l.c...p...t...G.sPl............VlK...A...D..G.L..A.A..G..K...........G...........V...l....VA...................o...h....-...E......A....t....p....A...l......c...c...h....h.......t.......s.......p.......t.......F.........G..........s.....A....G...p.........c.....V....V.I.EE.F.L....-...G...-..E..hS..h.hs..h..s...............D.........G........c.....p...h.l....P.h..s.s..u.....Q....DH.K..R..l..hD...GD.p.......................................................G.P..N.T.....G.G.M.GA.Y.o....Ps.P.h.l........o....p...........p..........l...........h.p..c.sh.cpIlpPTlcG.Mt.p..E.....G..p..sap.G.l.L.YAGLMls..psG..........PKVlEFNsRFGDPET................................................................................................................	0	403	790	1057
+2662	PF02843	GARS_C		Phosphoribosylglycinamide synthetase, C domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_916 (release 3.0)	Domain	Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see Pfam:PF02787).	21.80	21.80	22.80	21.90	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.90	0.72	-3.81	94	4668	2009-01-15 18:05:59	2003-04-07 12:59:11	11	41	4494	19	1219	3584	1998	93.10	39	20.27	CHANGED	sulsVVlAutGY......Pts..p+.Gh.lsh....t....ttpsshlFaAGo...................p....................tp..ss...............pllosGGRVLslsuhusolpcApppuYpslppl..phs.shaYRpDIGt...+sh	......................................................ulsVVlAutGY......P..s....s....Yc....K...Gs.IsG......................ttstsstlFHAGT....................................p........................................hp...ss.................pl.lT..sG..GRVLslsu..hG.colp-AppcAYp.tl.s.p..I.pa......c....u......haaRpDIGh+A.h........	0	384	769	1030
+2663	PF02844	GARS_N		Phosphoribosylglycinamide synthetase, N domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_916 (release 3.0)	Domain	Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see Pfam:PF00289).	24.30	24.30	24.30	28.30	24.00	24.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.21	0.72	-3.54	135	4637	2009-01-15 18:05:59	2003-04-07 12:59:11	10	33	4461	19	1204	3558	2108	100.50	48	21.94	CHANGED	M+lLllGuGGREHAlAhpL.tpSsplsclasAPG..NsGh...uph..ups....hsl........shsDhssls..paApcpslDLslVGPEsPLssGlsDthpp....tG......ls..lFGPoptAApLE	.......................................M+lLVlGuG.GREHALAaKl....spS...s...p........V.....c...p.lalAPG....Nu.Gh.......ut....u..p.s.........lsI.........shsDhsuLl.......sFAp..cp..pl-LslVGPEsPLl..t..GlVDsF..cs......s..G.....lp..lFGPopsAApLE................	0	383	758	1019
+2664	PF03198	Glyco_hydro_72	GAS1; 	Glucanosyltransferase	Mifsud W	anon	Pfam-B_2209 (release 6.5)	Family	This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261 [3].	25.90	25.90	26.20	26.30	25.50	25.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.10	0.70	-5.44	12	708	2012-10-03 05:44:19	2003-04-07 12:59:11	9	14	163	3	511	679	10	297.50	41	61.20	CHANGED	ssstutsss.sIpIhGN+FF.ops.......uppFaI+GVsYQPssSt...........SshsDPLADsc..sCpRDl.hhppLGlNTlRVYulssotsHDcCMphLpsAGIYlILDLssP..spSIsRtcP..oaNsshhpphhssIDsFpsYsNlLGFFAGNEVsNstssos..ussaVKAslRDhKpYIps+saRpIPVGYSAsDssssRlphAcYFsCGs.s...............s..+uDFaGhNhYEWC.Gt.SoapoSGYcs+sc-FcsasIPlFhSEaGCN....cVp.......sRsFsEVsslYSspMosVaSGGlVYpY.pEsNsYGLVplsssssp.hhsDFpsLKpphtplu	..........................................................ss.....sslssIplp..Gs..cFa..ps................GppFal+G...lsYQ.ssu...............................sshhDPL..uD..s..p..sCpRDl..shhpcLG..sNsIRVYslDsst..sH-cCMph.Lsc...AG...IYllhDlssP.........stSI.sR............s...s...P..................sass.shhpphhsllDtFupYsNsLG......FFuGNE....V..hNst.ss....os.......uusa...V.KAssRDhKpYIp....s..+..s.....h..Rp.IPVG.YSu......sD....s..........s.........p..h.R...phup.Y........hsCusss..................p...psDFaGhN..s.YpW..C...G.s....S..o...a....p.....s..S......GYsphscpF..p..s..a..s..lPlFFSEYGC....N.......p.sp.............PR.FsEltA.lY.....u.....s.....p.MosVa....SGGlVYpYh...pE...s....N...s....Y.....GLVp...l...s.s...s...s..s.h.....hhtDaptLppphtp..t.........................................................	0	101	260	432
+2665	PF02187	GAS2		Growth-Arrest-Specific Protein 2 Domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.59	0.72	-4.21	4	597	2009-01-15 18:05:59	2003-04-07 12:59:11	12	116	140	1	314	529	5	69.70	52	2.76	CHANGED	cpl-DtV+Rlltp..CpCsp+FpV.pluEGKYRhGDSphLhlVRlLRSpVMVRVGGGW.sL-caL.KpDPCRspp	................................plc-tVp+....ltp....C........pCsp....+.Fp....l.ppl..u..-..sK............YR..............h.........G...D.o..p..tLhll..Rl..L.R..o..p.VMVRVGGGW.sL-cFL.s.K...pDPCRsp.t......................	0	92	125	199
+2666	PF00741	Gas_vesicle		Gas vesicle protein	Bateman A	anon	Pfam-B_545 (release 2.1)	Family	\N	25.00	25.00	26.40	30.10	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.58	0.72	-4.08	52	505	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	154	0	197	506	18	38.70	48	35.03	CHANGED	uLsDlLDRlLDKGlVIsuDlplSlusl-LlslclRlllu	..uLsDlLDRlLDKGlVIsu.lplSlssIELLsIclRlllA.	0	71	157	191
+2667	PF01304	Gas_vesicle_C		Gas vesicles protein GVPc repeated domain	Finn RD, Bateman A	anon	Prosite	Repeat	\N	20.50	20.50	21.90	21.90	19.90	18.20	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.90	0.72	-7.35	0.72	-4.32	19	227	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	48	0	5	187	0	32.40	49	53.18	CHANGED	hppLpppTpcFLosTsppRhAQAcpQAppLppF	....ppLQppoppFLosTAptRhAQAccQApELhpF.	0	0	5	5
+2668	PF02704	GASA		Gibberellin regulated protein	Bashton M, Bateman A	anon	Pfam-B_1221 (release 5.5)	Family	This is the GASA gibberellin regulated cysteine rich protein family.  The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have some role in plant development. There are 12 cysteine residues conserved within the alignment giving the potential for these proteins to posses 6 disulphide bonds.	21.60	21.60	23.60	23.30	19.70	18.90	hmmbuild  --amino -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-9.96	0.72	-4.00	41	346	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	59	0	171	350	0	59.70	52	54.40	CHANGED	pCsspCstRCSposh.+chChphCspCCt+Ch.CVPPGTYGNKphC.PCYsshKT+pG...tsKCP	.........pCsupCshRCStsuh...pc...hChchCspCCt+Ct.C...VP.PGTa.G.NK......c..tC.PCYsshpT.+pG...psKCP.........	0	15	111	144
+2669	PF00918	Gastrin		Gastrin/cholecystokinin family	Bateman A	anon	Pfam-B_1542 (release 3.0)	Family	\N	22.20	22.20	22.20	23.80	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.78	0.71	-3.28	11	170	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	67	0	55	185	0	103.10	35	96.97	CHANGED	tsslClslllsVLusushscssshsc......sthpp............ssptthpshpptp........csctshuulhp+hLtttphst.huchushps.htpp-stcthtD+DYhGWMDFGRRSuEEh-hsu	......................tlslslLlssLu.h.u.shupss..sp........thtp.......................t..s.tt.psht..t.....................csctshuuhLsRhlpt.ttpst.su.cho.hhps.h.p.-..sat.tp.pDYhGWMDFGRRSAEE.-.................	0	3	7	20
+2670	PF00310	GATase_2		Glutamine amidotransferases class-II	Finn RD, Bateman A	anon	Prosite & Pfam-B_5381 (Release 7.5) & Pfam-B_455 (release 7.6)	Domain	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.22	0.70	-5.75	57	7459	2012-10-03 21:14:07	2003-04-07 12:59:11	16	48	3746	79	2152	13504	10212	226.90	25	23.73	CHANGED	CGl.Ghlsphpspso+.pllppulpuLpplpHRGuhss-.psGDGAGIhh..phPcphh.........th.h.......usu.hah...............t.hpt.h.t.s..lhuaR..lPht.t.hu..s...tt.P.h.Q.hlt..................................thc.pLahhR+.phpp......phttpt..........hYhsShs..sllYKG.hhs..l..a.a.DLps.phposhulsHpRaSTNThPsW.hApPhR.........hluHNGEINTlpGNpsahp..u+pthh..po..h.......t.h.Ph...t.............................................................................................................................sSDSsshDss.lEhhhtsG.hp...shhhhlP.sh..tp.ths....phpsFaca..hsslhEsWD..GPsulsh....o...D....G+...h..luAslDRNGL.R...PuRasl.T..............cDs...h.llhuSEs	......................................................................................................................................CGh.uhl................pp...plh.p.hh.phL.phpaRGh..........DusGlhh.....stt.h.................................................................................................................................................................................................................................................................................................................................................................................................h...a....th.t.........t..h.....u.t.....h...sl.hH...Ra.sT.s...s.............s...p..h......A.pPhh.................................................hlsH.N..G.......pls.s..hp.....t...hp.h...h....t..p.t.h...h...ts...........................................................................................................................................................................................t.S..D.o.t.............h......p.h.h.t.h...h...th............................................................h............t..p.sh..aph.....t......h...h..p.....h..c.......G...sh...s.h.s.h......................Gp............h..h..s.....h.D...p..Gl...RPhhhhhp..............tpt.......hhhuSE..................................................................................................................................................................................................................................................................................................................................	1	614	1255	1761
+2671	PF04572	Gb3_synth		Alpha 1,4-glycosyltransferase conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4980 (release 7.5)	Family	The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilise UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region [1].  	20.40	20.40	20.70	20.50	19.10	20.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.88	0.71	-4.47	17	301	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	96	0	207	294	11	127.30	29	35.50	CHANGED	hsF-sp...HplsttClc-hspsaNGspWGpNGPtllTRVl.+hhCpspshtthpp...pCht.holhsPsAFYslsa.pacpaFcs.ptcpshphlp........pShslHLWNKho+..shhlc.GSpshhthLhppaCPpsapustphh	...............................................hFp.p...H.hhthshc-FsppY...sup.hWGp...pGPtLlTRVh.+phCshp..sh.t..t...........tChs...hshlsspsFYPlsap.cacc.aF.cs.psp..p..t.h....p..h...hp......................so.YulHlWN..+hop..tht.hch.s.Sp.lhtpLhppaCPtsht.h....h.....................	0	63	97	152
+2672	PF02263	GBP		Guanylate-binding protein, N-terminal domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4308 (release 5.2) & Pfam-B_9065 (release 8.0)	Domain	Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.66	0.70	-5.33	13	1135	2012-10-05 12:31:08	2003-04-07 12:59:11	14	37	152	19	688	1289	39	218.70	30	40.25	CHANGED	cppLtlNpEALcIL....psIoQPVVVVAIVGhYRTGKSYLMN+LAG...........................pppGFSLGuTVpS-TKGIWMWClP....HPspPchTLVLLDTEGLtDhEKuDs+sDuWIFALAlLLSSTFVYNShsTIsppAL-QL+hVTELTchI+u+ss...t.sclcsussFVuFFPsFlWTVRDFoLpLEh-GpslTsDEYLEpuL+LppGpstclQs.N.sRcCIRpFFPc+KCFlF-+PutctpL.splEplp---L-s-FppQlppFsSYIao.cuhsKTL	..............................................ph.ls..p.A..lphl.............ph..h..s..p.s...l...s.VV......ulsGhaRpGKSaLhs.h.h..h..t................................................................p..G.F..sh..t.s.......ss....p...s..p..Tp.G.Ih....h.W..s.s...........................ps.p...t.....p...h.s.......llLlDT..pGhhs....p.....p....u.s...........p....s.............s....s..hl..FAL.u...s..h..lSS..h...l.YN........t.s....I...pp.p..s....lp.p.L...........p..h............ho-.........................................................st..h..t......p...t............h.............p............F..........s.hhahl.RDa..s.h....h..c.h..s.h.t...............s..tp.....p.a.L......-p..t...L....p...h...................t.....p..p.......p....h..p...p.........R.tp.......l..pphF..s.phpCFh..hspPs.ph.th.........ph..ct......t..pplp.pFhp...pht.h...h.hlht..t........................................................................................................................................................................	1	260	347	485
+2673	PF02841	GBP_C		Guanylate-binding protein, C-terminal domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4308 (release 5.2)	Domain	Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.72	0.70	-5.23	23	678	2009-01-15 18:05:59	2003-04-07 12:59:11	9	20	96	9	366	663	7	220.50	29	37.66	CHANGED	GGIhVoGs+LusLVpTYVsAIsSGslPClENAVlsLAQhENoAAVQKAlsHYpppMuQ+l.phPT-TLQELL-lHpssE+EAIpVFMcpSFKD..csQcFQKcLhspLcsK+c-FhcpNp-ASscpCpslLpcL.psL-cslppGsFStPGGapLalcc+cclcpcYpps...PcKGl+AcEVLQpF..LpS.......................+c.slpcoILQoDpuLTcpEKpIpsE+s+sEuAEtcpchLcpcpccppphMEsp-+SapEpl+QLpEKMEpERc.plhpEpc+hlppKLpEQcchLpEGFcpcucpLppEIpcLp	..................................GhpVsGp.tL.h.plhpsYlcslsu.G.s.l.Pshcssl.ulAphcNpuAVpcAhshYpppMpphh......p........hPh.p.......s....p.-.L.chH.pts...ccc.AlplFh...c...p...u.h..p..D.......s...p...p.......a..p.c.p..Ltpp.l.ccph..p..........s..F..............hp.pNpptu......thCpt...ht.........h.....h...............................h...................h..................................................................................................................................................................................................................................................................................................................................................................................................................................	0	107	154	219
+2674	PF02425	GBP_PSP		Paralytic/GBP/PSP peptide	Bateman A	anon	Pfam-B_2690 (release 5.4)	Family	This family includes insect peptides that are short (23 amino acids) and contain 1 disulphide bridge.  The family includes growth-blocking peptide (GBP) of Pseudaletia separata and the paralytic peptides from Manduca sexta, Heliothis virescens, and Spodoptera exigua [1] as well as plasmatocyte-spreading peptide (PSP1) [2]. These peptides function to halt metamorphosis from larvae to pupae.	25.00	25.00	31.00	42.20	20.00	17.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.43	0.72	-6.85	0.72	-4.42	3	25	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	15	11	3	34	0	22.90	81	27.38	CHANGED	ENFAGGCsPGYhRTADGRCKPTF	.ENFAGGCssGYhRTADGRCKPTF.	0	2	3	3
+2675	PF02526	GBP_repeat		Glycophorin-binding protein	Bashton M, Bateman A	anon	Pfam-B_1047 (release 5.4)	Repeat	This family contains glycophorin binding proteins from P. falciparum the malarial parasite [2]. Glycophorin is a cell surface protein of erythrocytes. The Glycophorin binding protein contains a tandem 38 residue repeat. In Swiss:P02895 the repeat occurs 11 times.	25.00	25.00	102.50	43.00	18.50	16.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.67	0.72	-4.56	9	59	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	4	0	24	67	0	37.70	83	63.70	CHANGED	TSADPEGQIM+tYAADPEYRKHlpVhYpILTNTDPNDE	.TSADPEGQIM+tYAADPEYRKHLpVhYpILTNTDPNDE.	0	24	24	24
+2676	PF04551	GcpE		GcpE protein	Bateman A	anon	Pfam-B_1482 (release 7.5)	Family	In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway [2].	32.00	32.00	36.10	36.80	30.10	30.70	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.12	0.70	-5.65	45	3640	2009-09-10 23:01:59	2003-04-07 12:59:11	9	7	3355	8	908	2655	3339	344.20	45	91.10	CHANGED	TRpVpV..Gs......VtIGGssPIsVQSMTs...TcTpDlcuTl....pQIpcLtcAGC-lVRluVsshcsAcAlppI+cp.....hs.lPLVADIHFs.a+lAltA...h-tul-KlRINPGNl.......................up.c-+hctlVctAK-pslsIRIGVNuGSL....pcclhp+Y.......tsTsc...uMVESALcalclhEchsF..pclllSlKuSclhhhlp.AYRhlupcs-.......YPLHLGVTEAGshhsGplKSulGlGsLLt-GIGDTIRVSLT...s-Psc....El............................................................................................................................................................................................................................................................................................................................................................................................................pluhcILpulsL.Rptus........clISCPoCGRs.thDLhplspclccplp..plc..........sl+lAVMGClVNGPGEuc-ADlGlu.uGpGp...uhlac+Gchl++s.sp-phl-cLlc.Iccht	.............................................................................................................................................pplhVGs......VslG.u......s......uPlsVQSMTN.......Tc.TpD.lp...ATl....tQIp............pL.pcuGs-....IVRluVPs.-uAcAlttI+pp.....ss.lPLVADIHFs.h+.hALts........s-hGlcplRINPGNI....................................................sp.--+lctllcsA+-pshPIRIGVNuGSL............-.+.clh.p.KY......................stsTs-........AllESA...hcpsc.lh-clsF..cphhlSlKuSDV...hhhlp..uY.RhL.A.p.p.hD......................................aP.L....HL.Gl.T.E.A.G.ssp......p.G.......sl.KSAlulGhLLt-GIGD.T.lRV.....S...Lo.......u.-.P....s.E....E.l.............................................................................................................................................................................................................................................................................................................................................................+....V...uhcILcol......sl.....Rs.p.u...l..........ph..lu.CPoCGRp.ph.D.l.hphspplcptLc...clh..........tshcVulhGCVVNGPGEAcpADlGls.uGssc.....uhlahcGchhcpl.s.psphl-pL.t.lct..th...........................................................................................................................................................	0	329	616	783
+2677	PF02155	GCR		Glucocorticoid receptor	Mian N, Bateman A	anon	IPR001409	Family	\N	25.00	25.00	29.60	25.50	18.70	18.30	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.21	0.70	-5.72	5	165	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	79	0	32	162	0	305.40	50	50.18	CHANGED	VhDFasshRGGs...olpsSsSssPTSluSQSsS+QQP.......lsuDhsNGLsNNssQPDLSKAVSLSMGLYMGEoEsKVMGNDluF..PQQsQsulSoGETDFuLLEESIAsLN+Sooss-sllGuss......Pp-htsLKTc.DsSsps+sclcuQsGSNGsStlKLslsDQ.....SThDILQDLELPssSP.GucoN.sPW..DhLhDEs...uLLSPLu.sDDoFLhEGN.hsEDsKPlsLsDoss..KlsDsucpsLLosuslslPQVKTEKE...DFIELCTPGVIKQENsGslYCQuulSGuslhGsKsSAISIHGVSTSGGQMYHYDhNTuTl.SQhQQDQKPIFNlhPPLPSuSEuWNRCQGSsD-shAolGslNhsuRosFSNGY.SSPuhRPD	.............................................................................shSss.s.husss..sssh.p........h.hDhspG.sss.s............................-LopA.lo.hohGlhht-s-s.KshspDhth...Q..Q...s..Q.....hul.os...G.......Epsh..p...L..LEESIAsLsp.....o..o...oss.-sshuuss......P.ch.....KTc...chS...-....ppp..h...csps.u.osGss.hcL.sssp...............sThD....I....LQDLEhsss.P....Gpcos..ssa...DhlhD-............sLL......SP...Lu.t-Dsh..Lh.-us..........sscDs.KP.llls.csps...............pl.pcsu............c...............h.L..s.............s.......s....s.sl.....shP....p.......VKsEK-...DFIcLCTPGVIKQEK..h...G.s.sYCQ......uuhsu..usl.u....s..+hS...uIS...lp.GVSTSGGQhYHYchNou.......Sh..uQ.Q..Q.DQKP.lFNlhPPlPssSEsW...NRsQGsG-ss...hs...shG..s..h.s........h.s...upos...FSsGa..SSPu.Rs-............................	0	1	3	11
+2678	PF04107	GCS2		Glutamate-cysteine ligase family 2(GCS2)	Kerrison ND, Finn RD	anon	COG2170	Family	Also known as gamma-glutamylcysteine synthetase and gamma-ECS (EC:6.3.2.2). This enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis. Members of this family are found in archaea, bacteria and plants. May and Leaver [1] discuss the possible evolutionary origins of glutamate-cysteine ligase enzymes in different organisms and suggest that it evolved independently in different eukaryotes, from an ancestral bacterial enzyme. They also state that Arabidopsis thaliana gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast and Escherichia coli homologues. In plants, there are separate cytosolic and chloroplast forms of the enzyme.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.67	0.70	-5.30	12	2189	2012-10-02 17:21:26	2003-04-07 12:59:11	8	10	1592	13	681	1830	1695	275.90	24	68.31	CHANGED	lGlE.Ehhls-.hsh.ht....pshh.ttshhshs...tsshhp...tstlEluss.PhsslpcshpphtpshptltphssphGlthhulGhpP.hphtph.lhsssRYpthhphhsp....s.upphhhtstplplslcsus-t......sthhphhhshhPlhhALuAsSPahpG+soGatSsRtplapphss...u.lPhshsc...acpahchhhcsshhtshp...............chahchRsss.h.s....hh-lthptssh.....lh.cthhch+hhsutst.chsshsshhhsshhcs..h.pstacAs+.hh	.......................................................................................GlE.Eh.lh.s....shths.............ps..hh......t...t.s..h...thp...............ss..p.h...hp-hstu.lElu.os..s...t....p....s..lp....pstsplsthhphltpsAs..ph.....s.....lt..l.husGscP....h..t.p....h....p....c...p...t..l...hs.p.t.....RY.......pt..h.h....ch.h................sh................................h..u...........p..............ph.h.......h...............h.......up..pV.......pVsl.ssu..............s-sh.................h.hhcshpthhPh...........hl.....ALu..AsSP.ah.pGp..s....oG.a...tS.....tR.p.la.p.......p.hss..................sGs..h.P.h..h.....h.....s......t...........t....ac....t......hhchhhp.....s.s.hh.shc..............................................ch.ah-h.R..sss..thu..........shE..lcsh.c......os........sh...c..thh.h...thhpu......h.s..h..h.h.l.s....t..h.s.h.h........h.t.....................a.......hh.stapus+.h.....................................................................................................................................................	0	201	465	597
+2679	PF01597	GCV_H		Glycine cleavage H-protein	Bateman A	anon	Pfam-B_988 (release 4.1)	Domain	This is a family of glycine cleavage H-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.40	0.71	-4.43	14	4486	2012-10-02 20:27:15	2003-04-07 12:59:11	14	10	3523	30	1292	3350	2660	118.10	40	88.84	CHANGED	LhYspcHE....Wl+scps.ssTVGITcaApcpLGDlVal-LPEsGsclpps-shuslESVKssS-lYuPloGpVlElNccLp-sPsllNccPY.tcGWlhKlKs...ss.c-hcp.LhsucpYtchlcc.	.........................................................................h+YocpHE..........Wl......+..........h....-.....u.....-................s.....sslGIT...............-aA..Q.-....tL.GD..lVFV-.L.......P..-......l..Gs......p.l.st.....G.-s.h..usl..E.S.V.K.usS..D...l.YuPl..o.GcVlpV...N.-s...L.p.-sP.......c.l.l.Np....-.P....Y....sp......GW..lhKl..ch.....s-.......s....p....l....c...s....Lhs.sptYpthh...t..........................................	0	431	806	1082
+2680	PF01571	GCV_T		Aminomethyltransferase folate-binding domain	Bashton M, Bateman A	anon	Pfam-B_933 (release 4.0)	Domain	This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase. 	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.15	0.70	-11.08	0.70	-4.96	131	7911	2012-10-01 23:12:28	2003-04-07 12:59:11	16	47	3499	47	2456	6628	15559	195.20	23	43.65	CHANGED	lhDlSp..huplplp......Gs-..At.....paLpplhssclstlt...sGpst.hshhLsp.pGtllsDhhlh+hscs.t............ahllssuustppshtalp......chhh.........plplpshosp...huhlultGP.....putpll...ppls....................sth.hhphtth.......h.....h........hlsRsuasGE..GaElhh.ss.............cp....stplactLht.s...thpssGhtAh-sLRlEtGhshhGp..........-h.s.pph..sPhEuuLt.ah	.....................................................hhDlSp.huhlplp...........G..s...-.....ut.....pa.L....p.tl...........hs.s.-..l...........s.p........ls..................sG.p...s...h...ashh..h.....st..p.....Gt...lhsDh..h..lhch...s-s................................ahl...ls.s...u...us..........t.............p..p...s.....h.s...alp...........................................phh.t...............cVplp....sh.ss.............huh.l.u..l..t....GP...........................put.t..hl.........tplh.........................................pt..h..h.h..tht.h.............h.s...h................................hlhp.s..u...........a.s.G.....E.....G....a..Elhh...st....................................pp......u.tlhptLht.....s..............................................l..p..s..s.Ghts..h..c.sL.R.lE....t...G...hshhup....................-h...s.tph........sPhpssht..........................................................................................................	0	718	1448	1998
+2681	PF04295	GD_AH_C		D-galactarate dehydratase / Altronate hydrolase, C terminus	Kerrison ND, Finn RD	anon	COG2721	Family	Family members include the C termini of D-galactarate dehydratase  (EC:4.2.1.42) which is thought to catalyse the reaction  D-galactarate = 5-keto-4-deoxy-D-glucarate + H2O, [1] and altronate  hydrolase (altronic acid hydratase, EC:4.2.1.7), which catalyses D-altronate = 2-keto-2-deoxygluconate + H2O [2]. As purified, both enzymes are catalytically inactive in the absence of  added Fe2+, Mn2+, and beta-mercaptoethanol.  Synergistic activation of altronate hydrolase activity is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre, but the function of  the single bound Fe2+ ion is unknown.  The hydratase has no Fe-S core [3].	19.40	19.40	19.40	20.40	18.90	19.30	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.23	0.70	-5.81	114	2289	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	1384	0	458	1521	2260	381.60	41	82.16	CHANGED	p.tTFpGY+RsDGp.VGsRNhlhIlsoVsCsssluctlActhptp................................................slD..........Gllsl.sHshGCu.hs...p-hphhp+sLtGhuppPNhuG.VLllGLGCEssphsplhps.....hsttt....ctlc........hhslQ-s..tG.tcslppGlphlcchltp.AsptcRpssshScLslGlpCGGSDuaSGlTANPslGhsuDhLlptGGTslLoEsPElhGAEclLspRAtsp-Vuc+llchlpha.cpYht.ptsssh.ssNPSPGNKtGGLoTl.EKSLGustKuGos.slssVlcYuE...lp..p.pGLshhso...........PGtDssusTu.sAuGsslllFTTGRGoshGsh.sPslKluoNoshhc+hp-.hDlssGsllsGptol-chGcclachllcVASGct.TpuEth..GppEhs.aph.....Gssh	..................p.hsFpGYRR.ss.Gp.VGsRNhlhIlsoVtCssslschlsphh.cc.................................................h...th...slDGV..s.slsH.aGCu.ht......ssth.hsh+sLtshuppPNhGu.VlVl..GL....G.CEp..Qsptlhcs......................hschss..............cpsp.............hhshQcp...G.pstl-sulphhcch.hpt.hs...pppRcssshSELhlGhpCGG..SDuhSGlTANPslGhsSDhLlpsGu.TslhoEssEhhGAEplLtsRAh...sccltc+Llphhsh.......acp.Yht.....t.t......p.p.sh.....ssNPSPGNKtGGLoTl.EKSLGsht.Ku.Gpo.sls-VLphG....-....+.p........p....pG..Lhhhso............PusDh.Vs.sTs.sAuGsplhl.FTTGRGTPa.Gsh..........VPs.........lK.........luTNopLsp+h...t-hhD.lsAG....slhpGt.pol-pl....upclhchIlclAsG+p.TpuEph.......tap-.h.ulapsuss.....................................	0	130	277	372
+2683	PF01150	GDA1_CD39	GDA1_CD39_NTPase; 	GDA1/CD39 (nucleoside phosphatase) family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	21.20	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.52	0.70	-5.99	9	1515	2012-10-02 23:34:14	2003-04-07 12:59:11	12	8	341	38	858	1436	26	351.80	24	78.66	CHANGED	.htpp-sh+YullhDAGSoGoRlaVY+a.sp..........c.shhtlsttlcc....hphlsPGLSoaupKs..................cpsuphLpPLL-hAcphIPppppsp..........TPVhltATAGhRLLtt-...tpptlLcsLpshlpshssa.spp..ptlpIIsGppEGhYuWIslNYLLG+hscc..............pppTsGslDlGGASsQIsFs.p..pt...stplcsst..hhpphchhspcY...slYspSaLsYGhspuhpphltpLlpssss..............hpsPCh..Ghppshshsslp................hthpususappCppplhcllp....st.Cs.p..pCtFNGVasPs....tppphtsSshaYhs.shhshsuph.....hs.pchscts+phCs..psWsplpsshspst.p.ls.....phChcssa.holLhsGFshshp..........cphpsspcIpsp-....huWsLGshl.hssshsh.....................pppLtss	.....................................................t.......pY.ulhhDAG.......So..GoRlalapa.t......................................................................p.h.....h........h..p......................ht.h.h..t..P.....G.......l.....S..s......asp.ps..........................pt.s.u.p.t.l.p.L.l.p.h.....Ahp...h.....l...P......t.p..h.h..tp..............TPl...hlh.AT.A.GhRl.Ls.p.......ptptll...pt......l.....p...p..........h.h...p.............t...sa..h..................ptspllsG.p.p.......E..Gh.auWlshNaLh.......G.phtp...............................................................tppThGh..lDhGGu...SsQ.....ls..F.sp...............................p..h..........tt.........................h......h.......p...h.phh..s....ppa.................plYspSaLsaGh....tAtpt....h..h..t..thhp.....t.t...t.........................................................................h.........p..PCh.....s.h.....p.....t...p.....h..ph.....t..t.............................................h..t.....u..t.u.....s..h..t..C..ht.h.....hhp.......................s.........................s........h....s....u..la............s.............pt..hh...h....p..aa..h...t.....h.....t....h..ht..........................phtphtttspphCt.......h.t.............h....t...................t................................................................hChphsahhslLh.p...G..aths.t...................................................lp.hhpplts..p.....hsWsLGh.h.l.hht............t................................................................................................................................	0	240	423	643
+2684	PF02347	GDC-P		Glycine cleavage system P-protein	Bashton M, Bateman A	anon	Pfam-B_840 (release 5.2)	Family	This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources.  The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC)  also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T [2].  The reaction catalysed by this protein is:-  Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.34	0.70	-5.79	13	6351	2012-10-02 18:26:03	2003-04-07 12:59:11	11	14	3103	20	1832	6081	5305	362.70	31	75.92	CHANGED	cRHIGsspp-ppcMLpslGhsoL--LhtpsVPssI+hpcshphsts............hoEpEhltcLpslAu..+Npl.a+SaIGMGYYsshlPsVIhRNlLENsuWYTpYTPYQsEISQGRLEuLLNaQTMlsDLTGLslANASLLDEGTAAAEAMthshphsKpK.tp+FlVspssHPQTlsVl+TRAcshslcllhsshp-hshos..........s-VsGVllQYPsT-GclpD...as-llcpAHpptshlssAsDLLALolL+PPGEhGADIsVGSuQRFGVPhGYGGPHAuFFAsppc.....htRpMPGRllGVo+DusGKpAhRLALQTREQHIRRDKATSNICTAQALLANhAAhYuVYHGspGL+cIAcRlHstTshLApuLcc..sshplpcshaFDTLplpsss.puspp.lLc+Ahtpt..lNLRhs-ss.slululDETsTccDl-sLlplF	.......................................................................................................................................................................................................................................................t........lPt.t.l..........t....p.....................h...s..ts......................................toEt-hlchl+pLus..............+.N...h..s.....p...u...h...I...shG..ps.h.p.h.sss..lpt.......h..l..p.Pta.....h..s..s..a...s..P......a.Q.P......E......h......u....Q..G...t.L.ch.lh..p.h.Q...p.h..............l.s-L.......T.Gh-....hs....s...s.S.L...s....p..u.s.....A...t..u.....E.......A....h.......h....l.......s.......h......R.....t.......t......+.......p......c.........p.s.....p.........h.....h..ls.ss...s.H...sps........h.s..........s.......h..........s...p.......A....p.h......h......G......h......c......V......l.....s.....s...s..h..p..p..p.s.s.hD....................................tss.l.u.ul.hlp.Y.P.u.T.p.G.h....h...E.....-.....lp.cl.sp.h.l.H.......p..t.G............u....h.l.h.l....u...............A.s....h.....A.l..s....h..Ls.s.P.....G...c.h..........G.......A...D.ls.ls...pps.F..u...lPhG.....h.GGPtsG.hus+sc........Ltthl....P.G..+.h.l.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	604	1157	1560
+2685	PF00996	GDI		GDP dissociation inhibitor	Bateman A	anon	Pfam-B_1220 (release 3.0)	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.44	0.70	-6.17	9	1094	2012-10-10 17:06:42	2003-04-07 12:59:11	13	17	362	23	674	1189	269	337.00	30	82.45	CHANGED	MDEE.....YDVIVLGTGLpECILSG.LLSVsGKKVLHlDRNcYYGGESASlo.LppLYp+F+st..........................tppP.pphG+uRDWNVDLlPKFLMANGpLV+lLI+TcVTRYLEFKsV-GSYVa+.........pGKIaKVPus-hEALsSsLMGlFEKRRh+pFl.aVssYcEsDspTaculD.p+toMp-lacKFsLspsT.DFlGHAlALapsDsYLppPAh.TlpRIpLYspSluRYGKS..PYLYPhYGLGELPQGFARLSAIYGGTYMLs+PlD-llatcs.GKslGV+S.ts-lA+sKpVlsDPSYhP...cKl+psG.+VlRsICIhsHPIPN...TssupSsQII.lPQsQlGRKSDIYlshlSasHNVssKGhYlAhlSTslETssPthElcPuLcLLGPlpcKFsplp-laEPhs-GscsplFlSpSYDAToHFETsspDVhsIacchsGpsLshsppptpp	........................................................................................................................paDlllhGTGL..Eslluu....h...hS.hp...G..pcVLHhDpss.a.YGu.p.....u..oh.s....lp....p...l...h.p...hh..p............................................................................................................t......t.h..s.p..s....+caslD.L..h..P.Khlhup...G.tLlphLlp.opV.s+Y.l-Fp.lts....a.lh.p...................................................ts...p..l......p.VP..s..s..c..-sht.o..h......h....u............hhEKRp.h.......h+Fh.a...l..................p....a............p.....t.......p.........p..s.........p.............p.......h..........p.....s........h.....p......t.........p......s....h....pp.h........h..p.p..a.......t...L.........t...t......sh........p.hh.h.a.ulAL..h....s...s.p...........h.p..t........s.......h................p......s...lp.c.hp.ha.....p.Slu+a......G..t.o.....P..alaPhY.G.h.G.ElPQuF.s.RhsA..la.G.GsYhLs...p...s...l...p...p...l..................h...........p..........p.....s....c.........h....h.u.......l...p.....s.......tt.......p...........h........h....p..s.....c.ll.....s......s.s..o....ah......................pp...s...p............h....s.....p.l..R....s.lhlh.p.p.sl...t..............st.p....s..t.....s...h....t...ll......hP.............t.....p..h......s..p...............p..t...................h.h.l..h.hu.sp.ss.spG.......hh.lhh.h.os........p...s.....t...p..........t.-.lt...s....h...t................................................................................................................................................t.......................................................................................................................................................................	0	223	348	528
+2686	PF02351	GDNF		GDNF/GAS1 domain	Bateman A	anon	Pfam-B_889 (release 5.2)	Domain	This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons [2].  GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity [3].	21.50	21.50	21.70	21.50	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.16	0.72	-11.45	0.72	-3.47	64	955	2009-09-11 15:54:25	2003-04-07 12:59:11	11	8	83	11	503	812	0	84.70	24	52.80	CHANGED	ClpAt.ctCpt-.pCpsthpt......ahppCts.........................tsstpCs...................scChpuhpsh.hsslhs................CpCpts.ppp.ppCtphtpphh.tssC	.............................CLcst.ctCpt-p..hC.p.p..thpt......ahppCts................................t.ssppCst.....................pcChpA...hpsh..h...ssshs....t...........CsCpts.........p.ptCtphhpphh..s.C...............................	0	47	105	259
+2687	PF02212	GED		Dynamin GTPase effector domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.88	0.72	-4.09	95	1604	2009-01-15 18:05:59	2003-04-07 12:59:11	13	34	368	21	867	1583	18	89.90	28	13.21	CHANGED	ppphpschIpph...lpSYasIVp+pltDplPKsIhah.........................llppsccplpppllppLhcpct...hspLLpEsstlsp+RcphpchlctLppApphlscl	............................phphchIcph...lpSYhp.I...l.p+sl.pD....t....l....P.K.s.Iha.h......................................................................hl...p..ps..K....c..p....l...p...s.c.LlspL..hp..psp.......hspLL...pEssphsp+...RcchtchlctLpcAhphlsp.............	0	252	456	678
+2688	PF04807	Gemini_AC4_5		Geminivirus AC4/5 conserved region	Mifsud W	anon	Pfam-B_3520 (release 7.6)	Family	\N	18.70	18.70	19.20	20.30	18.50	16.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.82	0.72	-7.28	0.72	-4.47	11	267	2009-09-10 17:27:41	2003-04-07 12:59:11	7	2	169	0	0	239	0	32.80	49	22.87	CHANGED	pIVLHpsustLlVcHlKaLoKlhhsu.htoTVos	..MpVLHuspTGLllKHlKahoKILhhh.pRoolTs.....	0	0	0	0
+2689	PF00799	Gemini_AL1	Geminivirus_AL1;	Geminivirus Rep catalytic domain	Bateman A	anon	Pfam-B_286 (release 2.1)	Domain	The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome [1]. For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer [1].	21.10	21.10	21.20	21.20	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.43	0.71	-4.23	11	3067	2012-10-02 18:54:05	2003-04-07 12:59:11	15	7	1057	2	10	2756	11	106.30	58	35.36	CHANGED	FRlpuKNhFLTYP+ColstEcsLppLtsLppphshp.YItlsREhHpDGpPHLHsLlQhEu+hphossRaFDLspspp..s.FHPNIQuAKSoscV+sYIsKDG....sohEaGpFphcu	..................................FplpuKNaFLTYP.+C.S.Lo.K.E.E.ALsQLpsL.p..o....P...s..sKK...a.....I+...lCRELH.E......DG.p.PHLHVLI..QFE.G.Ka..pC........p...N.sR...FFDLsSPoR...Ssa.............FH..PNIQ................u.A.K...S.S.o....DVKsYl-KDG....Dhl-aGpFQlD.G.................................................	0	4	6	6
+2690	PF01440	Gemini_AL2		Geminivirus AL2 protein	Bateman A	anon	Prodom_1117 (release 99.1)	Family	Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL2 gene product transactivates expression of TGMV coat protein gene [1], and BR1 movement protein.	25.60	25.60	25.80	27.50	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.86	0.71	-4.07	116	1883	2009-09-13 07:36:57	2003-04-07 12:59:11	11	4	905	0	0	1605	0	131.50	56	96.44	CHANGED	Mps..SSPSps+ST.ssIKspHRhAK+..+.slRRRRlDLsCGCShYlpIsCps..HGFTHRG.sHHCoSucEWRl....YL.GssKSPlFQDs.psptpslppppph.....ppssslQPQPpESsGsoQshspLPsLDslTsSDWu.Lps	.............MpsSSPSpsHsTpVPIK.VQHR.hAK+.....+slRRRRVDLsCGCSYYl..pI.sCp........N..HGFTHRG.THHCoS...u+EWRl....YL.GssKSPlFQDp.psppps.lppc.pH....ppsssslQsQPpESsGs....oQhFS.pLPsLDDlT...sSDWuFLK........................	0	0	0	0
+2691	PF01407	Gemini_AL3		Geminivirus AL3 protein	Bateman A	anon	Pfam-B_1874 (release 3.0)	Family	Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL3 protein comprises approximately 0.05% of the cellular proteins and is present in the soluble and organelle fractions [1]. AL3 may form oligomers [2]. Immunoprecipitation of AL3 in a baculovirus expression system extracts expressing both AL1 Pfam:PF00799 and AL3 showed that the two proteins also complex with each other [2]. The AL3 protein is involved in viral replication.	22.70	22.70	32.80	26.60	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.54	0.71	-4.65	97	1723	2009-09-13 21:06:47	2003-04-07 12:59:11	12	3	909	0	0	1578	0	119.30	59	89.59	CHANGED	DSRTGE.IT...AsQApNGVaIW-ls......NPLYFKIhpHppcPhhp....ppcIlplQIpFNHNLRKALGlHKCFLsFpIWTshps...tTGp.FL+VF+.......pQVh+YLcsLGVISINNVIRAVsaVLassl.pp...sl	..................................DSRTGEhIT...AsQAc.N..GVaIWEls......NPLYFKIhpHspRP.Fhp....spDIIolQIpFNHNLRKALGl....HKCFL.sF+IWTTLpP...pTGp.FLRVF+.......tQVlKYLssLGVISINNVIRAVcHVLasVlppT.h....................................................	0	0	0	0
+2692	PF00845	Gemini_BL1		Geminivirus BL1 movement protein	Bateman A	anon	Pfam-B_1535 (release 2.1)	Family	Geminiviruses encode two movement proteins that are essential for systemic infection of their host but dispensable for replication and encapsidation.	20.20	20.20	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.79	0.70	-5.03	17	508	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	260	0	0	471	0	250.50	54	95.03	CHANGED	sYIcScRsEYpLopDhT-IsLQFPSohpQhsuRLptpCMKIDHsVIEYRpQVPlNAoGoVIVEIHDpRhoDs-ShQAuaTFPItCNlDLHYFSSSFFSlKDPhPW+lhYRVsDoNVhpusHFA+hKGKLKLSoAKHSsDI.F+uPTlcILSKpaopcclDFapVshuKhp..R+Llpssshs...phuh+tP.lpltPGEoWAo+S.sIG............................st..spppspsspaPYRpLp+LssutLDPG-SsS.s......us.shopsplp-llcsTVpcClposspsspsKsL	....sYI-ScRsEYpLopDhoEIhLQFPSshpQhou+LptpCMKIDHsVIEYRpQVPlNAsGoVlVEIHDpRho-s-ohQAsaTFPItCNlDLHYFSSSFFSlKDs.PW+lhYRVpDoNVhptsHFA+hKGKLKLSoAKHS.sDI.F+sPTlcILSKpaTtcslDF.pVshsc.p..R+hlpsssht...phuh+tP.IpltPGEoWAo+S.pIG.............................s...sp.ps.pss.aPY+pLp+LssssLDPG-SsS.s......ts.ohShtplp-llcsTlpcCl.ss.pss.sKt....................	0	0	0	0
+2694	PF01492	Gemini_C4		Geminivirus C4 protein	Bashton M, Bateman A	anon	Pfam-B_453 (release 4.0)	Family	This family consists of the N terminal region of geminivirus C4 or AC4 proteins.  In Tomato yellow leaf curl geminivirus (TYLCV) the C4 protein is necessary for efficient spreading of the virus in tomato plants [1].	29.10	29.10	29.70	29.70	28.80	29.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.71	0.72	-4.25	79	1778	2009-09-12 04:38:53	2003-04-07 12:59:11	12	4	816	0	0	1410	0	82.00	49	82.94	CHANGED	MGsLIShssssSKsNosA+IsDSSThaPQsGQHISIpTFRELsss.hSsPT.p+TETshsG-sSRSh-DhLEEVuph.TTphPRp	..........MGsLIshsSSsSKuNosA+hsD.SSThaPQsGQHISIpTFRELN.ss.hSpPT.pRTETs.sG-s.RSh-DhhEtssp..hThhP+p..............	0	0	0	0
+2695	PF00844	Gemini_coat		Geminivirus coat protein/nuclear export factor BR1 family	Bateman A	anon	Pfam-B_1430 (release 2.1)	Family	It has been shown that the 104 N-terminal amino acids of the maize streak virus coat protein bind DNA non- specifically [1]. This family also includes various geminivirus movement proteins that are nuclear export factors or shuttles. One member BR1 facilitates the export of both ds and ss DNA form the nucleus [3].	23.50	23.50	23.80	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.35	0.70	-5.14	41	3840	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	1300	0	0	3087	0	202.70	48	94.35	CHANGED	RRphshss.....st...hpcssstp+stsp..htRpsphh+hh+ss........sh+lpshp......tschsls....ssuhsphlossspGps..spRsssthplKpltlpGplhh-cshpphsts.......sshhhaLVhDR+Pptssss....sFsplFsh...hpspsuohslpssl+-RFhVh+paptslssst........ss.h..hssppph.s+RFhphlsh+sha.ppsssGpYsNlpcNALllYhshhpssssshuoh.........hhlhFcsshss	.............................................................................Rthshsp...thsss...shstss.+tp.s....W.sp....R....P.M.....hRKP+.hYRhaRSPDVP+.......GCEGPC.K.VQSaE.........p+pDlt.HhGhl..hClSDVTRGsG..lTHRlG.KRF.ClKSl.YlhG...K.l.WMD-NIKppNHT........NsVhFaLVRD.RRPh.s.sP.....cFuplFNM...aDNEPSTA....TVKNshRDRaQVh++apusVsGGt.................h...us.+EQ.A..l.l+.+..Fh+.lNsaVsY..NpQEsu.KY.-NHoENAL.h.LYhshhp.ss.ssshssh...........h.Fh.sh.............................................	0	0	0	0
+2696	PF01708	Gemini_mov		Geminivirus putative movement protein 	Bashton M, Bateman A	anon	Pfam-B_1771 (release 4.1)	Family	This family consists of putative movement proteins from Maize streak and wheat dwarf virus.	25.00	25.00	33.50	33.40	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.00	0.72	-4.44	10	288	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	88	0	0	221	0	81.80	47	87.79	CHANGED	MDth.hss.h.spss....Pp......VPssAPuuuslPWSRVGElsIhohVAVlslYLLYsWVL+DLILVlKA++GRoTEElsFGssst+s....sussss	...........................pss.Y.pPR......VPo.uAPs.SuslsWS+VGEVuIhsFVAllshYLlYlWVL+DLILVLKA+pGRoTEElhFGspssctsss..h.........	0	0	0	0
+2697	PF01524	Gemini_V1		Geminivirus V1 protein	Bateman A	anon	Pfam-B_893 (release 4.0)	Family	Disruption of the V1 gene in Tomato yellow leaf curl virus (TYLCV) stopped its ability to systemically infect tomato plants, suggesting that the V1 gene product is required for successful infection of the host [1].	21.20	21.20	22.30	23.80	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.48	0.72	-4.00	45	1677	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	796	0	0	1216	0	75.00	69	68.72	CHANGED	MWDPLlN-FPE...TVHG.FRCML..AlKYLQt.lcpTYuPDTlGa-LlRDLIsVlRu+NYsEAopRYscFpuRl..puTspuELRQ	..............MWD..PLLNEFPE...oVHG.FRCML..AlKYLQh.lEpTYsPD.TLGaDLIRD.LIsVlRARsYVEAo..pRYsHFauRl..EGost..uELRQ............................	0	0	0	0
+2698	PF02053	Gene66		Gene 66 (IR5) protein	Mian N, Bateman A	anon	IPR000714	Family	\N	20.10	20.10	21.30	20.50	18.80	20.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.50	0.70	-4.91	6	66	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	29	0	0	57	0	175.70	37	67.47	CHANGED	Mpsha..........sDtphcosuthh..sutculYPhh.ssousHssSLPRSV+shApsVhssut-AhsAhRuGtPPPAclW.cVYchasssFpcaptS.....husFHsAsPlR+hVGchLhshssAP.ETHuELusRLLaCuYWCCLGHAusCShsphYE..csChRFF-pshGhGEsP.s-uEpYWpsLhshsuscsphh.+asAtsAahptRsR+hsls................u.sh	.........................ttthhcpsssp.........................sssusLYPlp.spshAHhshLPtshRshhcslspsSp.stssl+s..s.PPssthh.hlhcphphsaspahRu.....ppphpsl.PhRpAshsalss....husts.pTH...cchc-hLhh....CAaWCCLuHAu..........T..........CShAtLYs...sp..Ch+LFss.FGCGs..................................................ss.ss..................	0	0	0	0
+2699	PF03323	GerA		Bacillus/Clostridium GerA spore germination protein	Mifsud W	anon	Pfam-B_3821 (release 6.5)	Family	\N	20.70	20.70	21.00	20.80	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	470	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.23	0.70	-6.36	152	1955	2012-10-02 18:57:54	2003-04-07 12:59:11	8	8	418	0	415	1730	13	442.60	33	90.93	CHANGED	Nlphlc.phhs..pssDlhhRch....................tttshc.ssllalcGlsDpphlp..ppllcsL.....................ttttptphhpplh..pph...lshsplpphp.shccllpplLsGpsllhl.-Ghs..pulllsspsh...pRulpEPpsEpllRGs+-GFsEslpsNhuLlRRRl+sspLphcphplGcco+TclslhYIcsIss.cllccl+pRlppIclDsl.hssuhlEphIpDps.hosFPplt.TERPDtsuupLhEG+lsIllDGoPhslIsPsohhphhQssEDYap+ahhuoh.lRllRhhuhhlolhLPulYlAlhoaH.-llPspLhhslsusRpslPFPsllEsLlhElshElLREAGlRLPpslGpslGIVGullIGpAAVpAGllSshhlIlVAloAluSFshPsYphuhulRllRFhhllhuuhhGlhGlhluhhhlll+LssL+SF.GhPYLsPhsPh..phps.h+DsllRhPhhhh....p.pR.......Pphlp	......................................................................phlp.phht....pssDlhh+ph......................htshp.hslhalculsDpp.hlp..p.llpsLh........................................p..t..p......t.hp..p.hh..pph.ls.h.s...plpthp.shpclhptlLpGpsllhl.-.s.s.............p.s...h...lls.spsh...p..RulpEPpsEtslRGP+-GFsEslssNhuLlRR+l+sspLphcphp.lGcp.op.TclslhYlcslss.cll...pclcpRlp.pIchDs.l..hssuh.l.E.ph.I.p..Dps..hosFPphh.TERPDtssssLl-G+luIllDGoPhsLlsPsoahphhQosEDYhpphhh.uo.a.lRllRhh.uhhlulhhPulYlAlhsaH.pl..lPspLhhslhsuRpslPFPsllEs.LhhElshElLREAGlRLPpslG.pslGIVGGllIGpAAVpAGlsSshhlIlVAloAluSFshPs.aphuhuhRllRFshhlhAuhhGlh.....Glh.....lGhhhlhhHLspL+Sh.G.s.PYhtPhh...Ph...p...h...p...s...h+.Dhhl.RhPhhhhp.pRPt...p............................................	0	209	341	357
+2700	PF00196	GerE		Bacterial regulatory proteins, luxR family	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.43	0.72	-4.65	30	38873	2012-10-04 14:01:12	2003-04-07 12:59:11	14	273	4244	74	9895	30161	2583	57.10	31	20.74	CHANGED	hssLopREtpVLchlspGhoNcpIAppLslSp+TVpsHhsslhpKLslpucsplsphA	.......................h...Lot.RE.t..c..l..L.p.h...l..u.......p........G...h....o....s.p.c......IAppL.....t.......l......S.t.p.T.....VcsH.h...p.......s....l..h.p..K...L...s...lps.+sphshh.........................	0	3079	6345	8321
+2701	PF01353	GFP		Green fluorescent protein	Bateman A	anon	SCOP	Domain	\N	25.00	25.00	36.30	36.10	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.25	0.70	-4.97	27	306	2012-10-01 21:32:51	2003-04-07 12:59:11	17	7	114	621	18	1347	1	212.80	38	91.18	CHANGED	hssIK-pM+hKlpMEGsVNGHtFplpGcGcGpPacGsQ..shplpVscGuPLPFAaDILosuFpYGNRsFsKYPccI..PDYFKQSFPE...GaoWERshsaEDGGlsssosDIol...cG-.....sFhacl+FcGlNFPssGPVMQKKTh.tWEP.STEthYs..pDGlLpGclshALh.LcGGuHYpCch+ToYKuKKs.lph..PsaHFlDHRlEhhpccc.DhspVc.aEpAlA+hs	...............phlpttMph+lcM-GsVNGHcFslpGcGcGpPaEGpQ..shcLpV..s..c..GGPLPFuaDILossFpYGs+sFs+YPccl..sD.YFK.pu.h..P-...GYoaERohpF.........E.........DGGlsssosc..loh...cGs........shh.acl+hpGsNFPssGPVMpKK.Th..sW-P.S.s.Ep.h.hs..p-ssLpG.csshsLh.Lc.G...G.u+...apscacosY.....+....s..c....Ks...........l..ph.....P.shHalc+clphtp.psp..chpphp.hEhu.Ap.......................................	0	17	17	17
+2702	PF05165	GGDN		GGDN family	Bateman A	anon	COG2429	Family	I have named this protein family of unknown function GGDN after the most conserved motif. The proteins are 200-270 amino acids in length.	20.60	20.60	20.60	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.25	0.70	-5.33	4	106	2012-10-01 23:51:22	2003-04-07 12:59:11	7	2	91	4	64	115	25	210.80	32	93.13	CHANGED	M...shlQIDsYGPWTspPsPRREsDLQsLQucLYADlpc.huu+pGhVFhsRFDNMlulosGhsltsHcRlQ-uItNRYPlTVSMulusAcTPhDA.ctAspALpctGuAQsEpRpEsLsh.s.....ss-GYVpIAHIDlNslTtThTDhVushcThhpVpclhttLhchL..KhsAlh.FlGGDNhhAsssthp.t.lLclhsclc-phsl.....-LKAGIGhusTAccAusLAchALEcIR..Gths.sslsshcp	..................................h.sllplssYt.WT.o.sscREhtlQtlQucLatclpp.huthsuhsa.hRaDshlslsNGls.pphttl.pslppph.PlslshsluhucTPh-A.htAsttlpp.t.st.pt...p....................ss..ltluHhDlsshT.phTchhssa-oahplpphhhpLhchh.hp.hsulsh.....alGGDNhhs..h.st...hsppsh.phlpclpcphtl.............tl+sGlGhGpsAcs...AhhhAspuL.-tlR..tth..........t..................................	1	16	34	51
+2703	PF01134	GIDA		Glucose inhibited division protein A	Finn RD, Bateman A	anon	Prosite & Pfam-B_4007 (Release 8.0)	Family	\N	20.00	19.10	20.00	19.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	392	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.29	0.70	-5.61	122	6402	2012-10-10 17:06:42	2003-04-07 12:59:11	17	49	4313	22	1570	23497	12080	363.60	41	65.94	CHANGED	DVlVlGuGHAGsEAAhsuA+hGscshLl..............Thph-pluphsCNPolGG......AKGhLs+ElDALG.GhhucssDpsslph+hLNtp+GPAVtAhRsQsD+phYppthpctlcs...psNLplhpspVsclhspp................tth.G.lhht.s..h.sc........sVllTTGT.........aLtu.lhhG..th.sG...sp.hso.sLupsLc.c.hGhchtRhKTGTPPRlctcSIDasth.hpsu-.p.s.s....FSahsssh.......p...pcQ............hs.CalstTspps......HplI+cslc.pos.hasGp..IcuhGPRYCPSIEc...Kll+Fs...............-+spHplaLEPEuhsssp.hYhsGhSToLPhclQhchl+o.IPGLEsAclhR......GYulEYDalsPtpLh.s.oLEoKplpsLFhAGQINGT.oG..YEEAAA..QGLlAGlNAuh.phpscp	...............................................................................................................DVlVlG.u.GHAG.sEA.A.h..............Au...A..R.h...........G...h..p...slLl...........................................................Thp..h..-.....p.l....u....t...h.....s.....C.....N..P...u...l.G.G...............................u.K.G......h....L....l......+.....E......l........D........A.......L.....G........G.......h........h........u.....c......s....s........D.....p....s....t..l......Q....h.......+..........h......L..............N......t.....t.........K......G..........P.......A....V.......p........A....h.....R......u.........Q..s...D...R.......t.......h........Y.........p.....p........t....h.........p.....p.....t...l...c...s.................p..s..N..L...p......l....h...p..p........t...l...s.....-...l.h....s.pt......................................................tth..h.G.....s...h.....h.....t...........s.................h..t...u.p............sVllTTGT.................................................h.LtG..lhlG........p.....h....u.G..................t......p............s.S..h....s...........L.uc..pLc..c...hG.h...c.h......h.RhK.TGTPPRlcsco.IDas...hht.QsuD...s.s...............FSah.s..s.s.h.........p.....pQ................................hs...Ca.lohT.spps..................Hpl....lcsshc.....cus......h...asGh.........I-.u.h.G...PRYCPSIEc........Kll+Fs...................-+sp..HplFLEPE....Gh....s....ss..............p....hYhsGhS....T.S.LP..h.........clQ..hp...ll+o.I..................G...L..E.N.....A.......c...hhRs.............................GYAlEYDa.hs.....P.p.p.Lh.........s...TLE.......o.......K.......t...l..ps......LFhAG...Q...l....N...G....T.oG......Y......E......E......AAA....QGLlAGlNAAhthtsc.................................................................................................................................................................................................................................................................................................................	0	550	1026	1334
+2704	PF02527	GidB		rRNA small subunit methyltransferase G	Bashton M, Bateman A	anon	Pfam-B_1265 (release 5.4)	Family	This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision [1]. GidB has been shown to be a methyltransferase G specific to the rRNA small subunit [2, 3]. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA [4].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.85	0.71	-5.15	17	4375	2012-10-10 17:06:42	2003-04-07 12:59:11	10	8	4276	14	957	4510	3558	182.20	33	82.38	CHANGED	phpphptYhphLhchNpphNLouhp..chpclhp+HllDSlslhphlcptc...t...lhDlGSGAGhPGlPLulhhPph+....lsLl-uhtK+ssFLcpltpcLsLsplpllpsRsEc.......ttpaDslsuRAluslsclsphshp.Ll+ssGhhlthKGtpst-Eltphcpthphpth.hhplsth.tt....pcplh	.............................................................pph.tYhclL...hcW...N.cth..N...L....Tulp..-.p.-..h...hh+H...lhD..Sl.s..l..h.........h...l....p....tpp......................p....llDlGoGuG.h..PG.I.PL.u..I....h....h....P.c....h.c...........hT.LlD..S..l....s......KR..l..p..F...L.p...p..ltp.c....L.....s...L..p...s....l..p...s...l.p...u...R.s....Ep......................ht..c.tpaD.h....V.....s....u....R.....A....l......A.....s......L........s..s....l...s...p.h.....s....h......s...L...l......c..............s.......G...p........h......l........A....h.....K..G...t..p..s..p..-.E..lt...p.h.pp.....s....h.p..h..h..th.....t..............................................................................................................	0	336	646	821
+2705	PF03227	GILT		Gamma interferon inducible lysosomal thiol reductase (GILT)	Mifsud W	anon	Pfam-B_1477 (release 6.5)	Family	This family includes the two characterised human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: Swiss:P13284 [1] and Swiss:Q9UL08 [2]. It also contains several other eukaryotic putative proteins with similarity to GILT [3]. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.	22.00	22.00	23.70	22.60	21.20	19.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.24	0.72	-10.81	0.72	-4.20	15	522	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	214	0	342	525	3	107.30	27	45.18	CHANGED	lplslaYESLCPssppFlpppLh.hh..hptshtshh-LcLlPFG.pAcsscsto.....spCQHGspECcLNtLpACsIcshsspph..........hshlsClpps.pshppuh......Cspchthpp	................................lplslaYESLCPssp..pFlhppLhPhh.....p..p..ltsh..lsl..pLlP...aG..pA..p...hp.s.sss................hpCQHGspEChhNhlpsCslph.h.......p....p.h................hthlhCh.pt...t...p........t.t..........Chp.....h............................................................	0	138	199	293
+2706	PF03359	GKAP		Guanylate-kinase-associated protein (GKAP) protein	Mifsud W	anon	Pfam-B_1892 (release 6.6)	Family	\N	19.20	19.20	20.40	20.00	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.39	0.70	-4.83	20	511	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	91	0	233	441	0	312.50	34	40.76	CHANGED	-s+tt....p.h..pIuhp...........h.p.pths.sp.tsc..t.hpSlGlQVc-chp.ptchp.................tosusousspsD.chps..t.s....ssspspsh..s..sshp+p.pp..........ss...pssthth.p+sVs.................pputhsh.............sstsscspsss.psuthsPsps....................................................t...sp+DGpaFl+LLpuEs-RLcuaCpphE+-.....tc-s-LsE.Ell..........GhIRoAVG................pApLLhoQKFpQFctLC-p........................................sh..........s..Psup.csTspDLsGFWDMLpLsIEDVshKF--LppLKsNsWp................ccssPshsKKPsKs................................+sshs+s+uh-uu........ttpRtcARcRLhAAKRAAphRQsp.......socpu-SlEIalPEAQTRL	........................................................................................................................................................................................................................tt............................................tt.....t.........hpS..lGl..Qsp..cp.h.p..............p.p.................................................s.ps.....h.osthp.s.-.php.t....t.........t.ppps.h..t.......tshtpp.p.....................st..................pslp...................................................................ps.hsh.....................................s..ps.s..s..s..h..psu.h.s.P..s.s..s..hps..p...................................................................................tssphuss...pRD.Gpa....F...l..KLL.puEs.-.RhEuWCppME+-........tcEss.L....sE...-l.L............G+IR.oA.VG................sAQLLMoQK...F.pQFptLCpp........................................sh...............s.....Ps.ut..P..cPTsQDLAGFWD.h.LQLsIEDlshKFc-LppLKsN.sWp.hp...................pp-c.....c.ssPsh.s...KK..ss.+s....................................................psshs....+p+u.-ss..........p.R.pcA...RcR...L.hAAK+.A.sphRpss.......tpEpu-..ohphhhsp..............................................................................	2	56	73	140
+2707	PF03275	GLF		UDP-galactopyranose mutase	Mifsud W	anon	Pfam-B_4203 (release 6.5)	Family	\N	25.40	25.40	25.50	25.40	25.30	24.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.56	0.71	-4.81	96	1461	2012-10-10 17:06:42	2003-04-07 12:59:11	8	6	1183	57	272	1189	350	188.00	47	53.74	CHANGED	thh+uYTcKQWGpcP.p-Lsu...sllpRlPVRhsaDspYF.sDpYQGlP..hsGYTphhEp..MLt.pts.....IcVpLss..Dahchpc................thttcllaTGsIDpaF-Yp...hGcLtYRSLcFE...........pcsh.spssaQGsuVlNYs-.p-hPaTRIhEaKHFps..........ts+Tlls+EYsp.h.....pcu-.....PYYPlssscsppLap+YpcLAcppp...sVhFsGRLusY+Y	............................thlKuYTtKQWGpss.p-LPu..............lIp..........R.L.PVRh..sa..........DNpYF.sDpYQGlP..hsGYTthlEp........M.....L.t...tps........I-VcLss..Dahp.+c.....................th.s.h...s+llaTG.lDpa...........F.-.Yp...hGcLtYRoLcFE.............pEhl...c........tsa.QGsAV.l...NYs-......t-sPYTRIhEaKHFp.t........................p.psKTlI.s...+EYst.h....ccG.D....EPYYPlNspcs..ptLappYpphAp.p.ps..........p.VlFsGRLGpY+Y...................	0	85	177	232
+2708	PF02812	ELFV_dehydrog_N	E_L_F_V_dh; GLFV_dehydrog_N; 	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	25.30	25.30	25.40	25.50	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.44	0.71	-4.57	262	6065	2009-01-15 18:05:59	2003-04-07 12:59:11	13	15	3955	213	1526	4625	1317	125.30	45	30.51	CHANGED	sc+......llhsph.h........ct.uphpshpuaRs.HssshG.PsKGGlRa.aP.t..............................ls.s....-lhtLuhhMTa..KsAlssLPhGGuKGul...hhD.......P+..ths.......ppE.hcclsRuasptltp...lusspslsAsDlGTssp-Mualh..cpappls	......................PcRhl.hclsh......h.Dp.Gplps.cGaRlQassAl...G....Ph....KG....G.lRFHP.s..............................Vshs.........lKhL....uht.oa..KNul......s........s......LP.hGGGKGG........chD..............P+..shS.......csE..l.RhspuahpELtc...alGs.spDVPAsDlGsuu+-huahh.spYc+l.p......................................................	0	538	1003	1309
+2709	PF00120	Gln-synt_C	gln-synt; 	Glutamine synthetase, catalytic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.60	22.60	22.60	22.70	22.30	22.50	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.73	0.70	-5.24	95	12610	2012-10-02 17:21:26	2003-04-07 12:59:11	19	19	7069	255	2691	9179	7704	221.90	30	57.41	CHANGED	stsPRs.lh++shpthpp.tGhs..shhGsE.EFaLhct....sc....ssts....sthss..........................hpsGhaslss..h-.pspclhp-hhpsh.tphGl.plEstH+EVusu.QhElshc.hssslcsADplhhhKhll+plAccaGhtATFMPKPhhsss..GSGMHsHhSlht...ttG.pshFhssts....sLSchuhpaluGll+HstulsAhssP......ssNSY+RLsP........uhpAPshluauspNRoAslRlPts......tsspupRlEhRhPDs........suNPYLuhAAlltAG	.................................................................................................t..ssRt..hpc.h..t...h..t.t........uhs.................shhG......E..Eaalhcp........sc...........s............th..............................................................t...hsu..h..ashss...hs...hpsh.hp-hhthh...t.h..Gl...s..l-.shppEV...............u...............s...............u....QaElsht.h.......s.......sslpsADph.............hhh+hll+plAc......p......a...........G.htsoFhsK..Phhsts.......G..oGh.Hsph..Slh.........t.................s....shh...........................st............t................t.....hs.p...th..hl.u....G.h.h.p.ph.......t......h.......shhss.........sssua+RLss..........th..A.s..s..hsau.........h........p..N.R...ss.........lRlPhs..........................t..ttclE....R.s.ss....................sssPYlshushh........................................................................	0	856	1657	2250
+2710	PF03951	Gln-synt_N	gln-synt_N; 	Glutamine synthetase, beta-Grasp domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-10.05	0.72	-4.40	188	7416	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	5499	249	1602	5187	2852	76.40	36	19.43	CHANGED	slcalchpFsDhhGthp.......plshs.......h..spl.........ccs.........hc.pGh.sFDGSSltGatslpcSDMhLhPD...sT..hhl-P..apt..t.....s.hhlhC-lhss	........................................................lphlchhFsDhhGh.p...........plphs...........pph..............pph.....................................hp...ps...h.hFDG.SSl..tG.a......s.t.l......p.cS...DMl.LhPD...po..hh.lDP...apt..t.......s..hhlhC-lhpP..................................	0	504	986	1339
+2711	PF03710	GlnE		Glutamate-ammonia ligase adenylyltransferase	Yeats C	anon	Yeats C	Domain	Conserved repeated domain found in GlnE proteins. These proteins  adenylate and deadenylate glutamine synthases: ATP + {L-Glutamate:ammonia ligase (ADP-forming)} = Diphosphate + Adenylyl-{L-Glutamate:Ammonia ligase  (ADP-forming)}. The family is related to the  Pfam:PF01909 domain.	20.50	20.50	20.50	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.51	0.70	-5.12	22	4102	2012-10-02 22:47:23	2003-04-07 12:59:11	10	13	2001	3	970	3413	962	243.30	33	50.29	CHANGED	ltpLhplhutSshlucplt+p....PhlL.cpLhs...hspspshpthtspLpphLhpsss-.....E............................phhcsLRpF+ppphhRIAhsDlhuhhs............lpclsppLotLA-AlltAulphhhppsssch.shP.t.t.sps..shhllGhGKLGGhELsauSDlDLlFhassssts.....sut+sl-stpaasRluQ+llphLst.TssGhlYclDhRLRPpGsuG.LshohsAapcYapppupsWE+.Ahl+ARsls.Gstplptpa.ph	.............................................................................................h..pLhplhutSshlsc.lt.p..p.........Pt..h.l..sp..Lhs...................p.s.....t..h..p..t...h.....t....s..p...L.p...p.h...Lh.....p...sssc..........p...............................................................phhcsLRph+ppphlR...IAhs.D.l....su..h..h.s......................................................................lt...plsppL..otLA-uhlsuul.ph..s..htph..st......c........a...G.......P...................t............p.....t........p......s......p...sh...................sllGMGKLGGtELsauSDlDLIFlacpssss..........................sutc.t.l..ss.t...paa...sR...lup+l....hpl....Ls.p...........T.......s.....s.Gh....l.acVDhRLRPpGsuGsLVhShsAhpcYh....p....p....p......u................h..sW..E+.Ahl+ARslu.G-..plttph..t..................................	0	261	591	797
+2712	PF03616	Glt_symporter		Sodium/glutamate symporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.20	21.20	21.20	21.50	20.70	21.10	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.18	0.70	-5.96	8	1846	2012-10-02 17:06:44	2003-04-07 12:59:11	9	4	1484	0	231	1070	118	354.70	42	89.10	CHANGED	lpLsshpTLllAsLlLLLGpall++lsFLp+asIPEPVlGGllVAlslhll+phtshclsFDtS.LQsshMLsFFoTIGLuAshspLhKGGKsLllaLhssssllllQNsVGluhAulLGlcPLlGLlAGSIoLoGGHGTuAAWussFt-p.aGlsuAsElAhACATFGLVhGGlIGGPVA+aLlp+pp...pspspsDsp-p.lspuaccsptp+pIsupsllETlsllslClslGpalusLlps...puLpLPoFVhsLFlGVIlRNhLohhhhap...V.-csVslLGsVuLSLFLAhALMSL+LWELtsLAlPlLlILsVQslsMlLaulFVTFRhMGKDYDAAVlsAGHCGFGLGATPTAlANMpuVTc+FGP	...................................................................plsshtTLshAs.llLLLG+hlspplshL++asIPpPVsGG.Ll.........s.........A.l....h..........l.......hl.....L............c......p........h....hs....h..................p.................l.....p....F....D....h..s............L...p..s.....s.......hML.sF.Fs..T...I.....G..L.........s..A.............s.h....s...p..L.....+.........t....G..G......+...sl...h.........l....F......l..h....ls.s.s.l..l.l.h.Q.N....s.l..G.....l......u.....h.....A..p.....l.......L......G..l.....c..P.L....h....G...L.....l..A..G.....S...I...oL..oG...GHGTuAAau.p.hat.-t..aG.h.....ssAh.pl..AhAsATFGL.VhGGLIG....G...P.V.A......+a.....Llc+tp......................hps..s..t.....t.......s.......-.........s.....p...........p.........................s...........p..........s...........a.......c..........p....s......p...t........s.....+....h........l.....T...u........s........h.........lc.........sl....s....l.........lslC....ls..lG.......p.......h.......l.u....p...h..l...ss.............ssh..........p....l....P..........s..........F....Vs..s..L..Fl.....GVIl....pNhl.s..h.h.t.h..hc..........l.............p..+.s........l..s..l.lGsVSLS.........LF.L..AMALMoLKLWcL.s.s..L..Al.Phll.IL.sVQ.slhMsL...a.Ah..F.V.T.a.RhM.....GKs..Y..DAAVluuGHCGFGLGATPTAlANMpulTc+aGs...................................................	0	69	132	190
+2713	PF01744	GLTT		GLTT repeat (6 copies)	Bateman A	anon	Pfam-B_681 (release 4.2)	Repeat	This short repeat of unknown function is found in multiple copies in several C. elegans proteins. The repeat is five residues long and consists of XGLTT where X can be any amino acid.	21.00	21.00	21.10	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.16	0.72	-4.49	35	266	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	125	0	137	344	218	28.60	43	14.72	CHANGED	GLsThGLsThGLsThGLsThGLsohGLsT	........GLss.GLso.GLso.GLso.GLso.GLs.............	0	84	101	125
+2714	PF02686	Glu-tRNAGln		Glu-tRNAGln amidotransferase C subunit	Bashton M, Bateman A	anon	COG0721	Family	This is a family of Glu-tRNAGln amidotransferase C subunits. The Glu-tRNA Gln amidotransferase enzyme itself is an important translational fidelity mechanism replacing incorrectly charged Glu-tRNAGln with the correct Gln-tRANGln via transmidation of the misacylated Glu-tRNAGln [1].  This activity supplements the lack  of glutaminyl-tRNA synthetase activity in gram-positive eubacterteria, cyanobacteria, Archaea, and organelles [1].	20.70	20.70	20.70	20.70	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.09	0.72	-4.18	191	3483	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	3411	33	945	2164	1701	72.20	30	68.71	CHANGED	ls-..cEhpphsppLssILcah-pLsc..lDTs...sVcPhsps........h....s.hp.........sshR-Dts.....ppsh..s...p-phLsNAPpp.....ccs.hFtV	.....................lo--EhpphsspLspIlsh.l.-.p.Lsp.l.D.Ts......uV..cPhsps........h............c..hp.................................ss.hR..-.D..hs................pp.uh...s.....p-chLp.NAP.cs.....css.hahV................................................................	0	327	621	803
+2715	PF05096	Glu_cyclase_2		Glutamine cyclotransferase	Bateman A	anon	COG3823	Family	This family of enzymes EC:2.3.2.5 catalyse the cyclization of free L-glutamine and N-terminal glutaminyl residues in proteins to pyroglutamate (5-oxoproline) and pyroglutamyl residues respectively [1]. This family includes plant and bacterial enzymes and seems unrelated to the mammalian enzymes.	20.50	20.50	21.20	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.63	0.70	-5.37	3	437	2012-10-05 17:30:42	2003-04-07 12:59:11	7	3	394	9	188	420	289	246.90	34	86.35	CHANGED	M+....L.LpphuhLsLAA...........shu.AA.VhuA+uPVht.+Vl+oYPHDosAFTQGLpYLssGHILESTGphGcSclRVa-Lcsutlptcpslsssl...FGEGlTslcspVYtLTWpDGVAapYDtcTFcsLGcasYpGEGWGLT..+DsKsLhMSsGTAFLpaRDPKTFAtpcoVQVTDpGVPVopLNELEYVcGpLYANVWQTsRIARIcPsTGKVluWIDlSsLL+Elulcuo+.sp....DDVLNGIAa.s-psRLLlTGKLWPpLFEVKLst........tN	.....................................................h..hh.........................................................................h.......t..h..cl..lpp.aPHDsp..uFTQGL....h..ts.........s............p...Lh.......E........STG...............h........h.G..p.....Spl..+.......c...h.......c....l...p...o..........G.p..........s..........h......p.......p.......hp......Lss.ph.....FGEGlTh.h......s...c......c......lapLTW+pthu.ahaDh...s..o...........h.p..............l.t.p...h...s.Y.....p.......u.......E...GWGLs.................p-...s.........p.p..LlhSDG.ospLh.......h.....hD..P..........p......s......ap.......hp.p.......l......p......V...s..t.....p......u..ps..lpp.LNELEa.l.........s..G......p.......laANlW........o.......spIhc..I-PpoGpVhuhlD...hs...sLh.t..th............t.....................sVLNGIAa.....s..p.........ps.........c............halTGKhWsplaElch....h.........................................................................................	0	80	145	177
+2716	PF04262	Glu_cys_ligase	glu_cys_ligase; 	Glutamate-cysteine ligase 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that carry out the first step of the glutathione biosynthesis pathway.	20.10	20.10	20.20	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.30	0.70	-5.96	7	1652	2012-10-02 17:21:26	2003-04-07 12:59:11	9	13	1468	18	291	1175	573	336.30	42	63.50	CHANGED	uctlthl..pppsphLppht+GlEREoLRVsssGpLuhTPHPtslGusLTH.hITTDFuEuLLEhITPsspcl-phLs.Lp-lHcaspspLts.EhlWPLSMPstlss-EsI.lAQYGsSp.G+hKplYRcGLthRYGchMQhISGIHYNFSLP.phashlhptps.ptstp-h.SuuYhplIRNahRauWll.YLFGASPAlsSuFLpsp.ppL..c+h........tpthhYhPYATSLRhSDlGYsNssptsLslsFNslppYlpulppAlcTPstpatplGlht-.GphhQLNsNlLQlEsEhYusIRPKRssppGEp.hpALhppGlpYlElRsLDlNPFsPlGIshpps+FLDlFhlaChhtDus.hDtp-htpspsNapcls	.........................s....thl...tp.t.phlpthp+GlEREoLRVs.s.-.G.p.LApTs.HPc.uLGusLTH.aITTDFuEuLLEhITPls.ssl.pchLphLpslHchst.c...pl....s.c....EhhWPLSM...Pshl.s.p.p.p.-.I.lAp..YGoSN.GphKslYRcGLtpRYGthMQ.sISGlHYNFSls.shaps.hh...s.....t........p......s.....................t.......t....st....p-...hhSstYhclIRNahRasWllsYLFGASPul..ssuFlps..c.....p...p.L.......pph..............................tt..shha.hPa.ATSLRh.S.D.LGYs.N.c.s.Qs..s..Lt.l..s.aNsLppYlsuLcpAlcss...a.tlGh.......t..s..p...hQ.l.NsslLQIENEhYusIRPKphstsGEpPscALhctGlcYIElRsLDlNPFoPlGlspppl+FL-LFhlashLs.D.us.ph.ss.s.-.htphp.Nhppl............................................................	0	62	142	226
+2717	PF01645	Glu_synthase		Conserved region in glutamate synthase	Bashton M, Bateman A	anon	Pfam-B_719 (release 4.1)	Family	This family represents a region of the glutamate synthase protein.  This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organisms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.02	0.70	-5.54	15	5264	2012-10-03 05:58:16	2003-04-07 12:59:11	12	61	3389	15	1586	7292	7907	342.40	41	29.94	CHANGED	Hh.ssths+pLppAsps..........tshssacpYpchhscc.hlsslRshLchcsscss...........lslppVEss.plhpRFsouuMSaGALScEAHpuLAhAMNclG.upSNoGEGGEssp+hcsssss.......................tIKQlASGRFGVo.............scYLssActlEIKlAQGAKPGcGGpLPGcKVos.IAclRtssPGVsLISPPPHHDIYSIEDLAQLIaDL+plN..cA.lSVKLVuptGlGsIAuG....VAKAsADhIhIuGa-GGTGASPhoulKauGlPWElGLsEscQsLhpsuLRc+VpLpsDGGL+TGtDVshAshLGA-pashGTuuhIAhGClhsRhCHTNsCPlGlATQDPcLR..t+atGsPc+VlNahhhluEElR-lhAphGap	.......................................................................................................................................p......h..ust.................p...a.ptatt.h..p..p..p..........h..t.lR..thh.thp.....t...t............l.s.lppV-.s.s.t.p.lh.p+.FssuAMSaG.u.lS...E.........A.HpsL....AhAh......Np....l.G......utSN......oGE..GGEs.st.+.h.t.s.t.t.ss.................................................................................tIKQ..lASGRFGV.s.......................stYL..s..s....u......c.tlpIKlAQGAKPGE.GG..p..LP.....Gp.....K..V.ssh..I.......A...ch....R..t...u..sP.....G.l...s..LI....SPPPH....H...D..............IY.....SI.....ED.LuQ.............L.Ia.DL.Kp.s.N....p..u...luV..K.....L...V..u......p......s......G......l.......G...s....l..A.s..G..........V.u....K....A....t......A...DhI...s....I.u..G..a.-.G.......G...T...........G........A..........o......P.......h.......s......u........l........c....a........s........G......h...P......a.........E.........l.......G...L........s......E.........s.........p.......Q........s...L....h...h....N....s.......L.........R..........s.......+...........l....p...lp...............s.D.G.tl....+T....G....t..............Dl....s....h.A....s...hLGA...-...p...a...G...huTu...s...h...l.u..h......G................C.....l.................h.................h.R..................h................C................H...h...s...s...CPsGVATQ........s.s..........p........LR................t..........c..........apG........psc+V.hN.......ahphlAcE...lRclhAplGh.t.........................................................	1	495	1024	1355
+2718	PF02364	Glucan_synthase		1,3-beta-glucan synthase component 	Bashton M, Bateman A	anon	Pfam-B_686 (release 5.2)	Family	This family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2 and Gls3 from yeast. 1,3-beta-glucan synthase EC:2.4.1.34 also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall [1]. The reaction catalysed is:- UDP-glucose + {(1,3)-beta-D-glucosyl}(N) <=> UDP + {(1,3)-beta-D-glucosyl}(N+1).	24.30	24.30	27.70	26.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	818	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.59	0.70	-6.67	9	769	2012-10-03 03:08:05	2003-04-07 12:59:11	10	21	230	0	498	771	22	530.20	35	43.68	CHANGED	-FFPssSEAERRIoFFAQSLuTPlPEPlPVDsMPTFTVLlPHYSEKILLSL+EIIRE--.hS+VTLLEYLKQLHP.sEW-CFV+DTKlLu-Essh.psstp.pc-p.............................t.hppKhDDLPFYsIGFKsAsPEYTLRTRIWASLRo.....QTLYRTlSGFMNYS+AIKLLYRVENP-lsQhFuGNs-tLEh..EL-cMApRKF+hlVSMQRYuKFs...t-EhENsEFLLRAYP-LpIAYLDE-Ps.pputEsphYSALlDGasEl.-.NspR+PKaRI+LSGNPILGDGKSDNQNHulIFYRGEYIQlIDANQDNYLEECLKIRSlLuEFEEhphssssPYsssht...p.pspPVAIlGAREYIFSENIGlLGDlAAGKEQTFGTLFARTLApIG.GKLHYGHPDFLNuIFMTTRGGlSKAQKGLHLNEDIYAGMNAhhRGGRIKHsEYYQCGKGRDLGFGSILNFTTKIGoGMGEQMLSREYYYLGTQLPlDRFLSFYYAHPGFHlNNlFIMLSVQhFMl..lLlNLGuLp+pshsCpYDps...pc..hP......GCYNL.PllpWlpRsllSIFIVFaIoFlPLhVQELhERGha+AhhRhh+HhhShSPhFEVFsCQlYupulhssLsaGGARYIuTGRGFATsRlsFuhLYSRFAssSIYhGucshLhLLFuoho........lWhstLlaFWlolluLClAPFlFNPHQFuWsDFFlDYR-alRWLoR..GNS+.+tsSWlsasRloRoRlTGaKp+hlu..s-ctshDssRAphpNlhhuElhhPhhlhhhshlsYhFIsSpsGss................ppsossllRlhIlshhPIhhshslhhhhhhhusshGPhhs	.....................................................t.-ApRRltFFspSL...h...hs.....s...lptM.s.a.ol....hhPaYtEphhhs...................p...................pl....................................p.............p......ptlohl.YLp.p..........la...............-WtsFhpch......t....................................................................................................................................................h.hh.h..u..c...............................t........t....u.h...............................................................................................................................thpt.sthKFphh.hshQ.ht..p.............pht.....sh..Lh.........t..t.lplual..-..............................................t....t.......................t...............ha.S.h.Llcs......................................................................haplpLsG.s......s.h.lG-GKs-NQNpullFhRG-hlQhIDhN............Q.....................DsY.hEEshKhRslLtE........a....................t................................................................ssIlGhREalFots.u.Lu.hhu.pEpoFsTlhtRhhu.......................h..s+hHYGHPDhhsthahhTRG.GlSKAp+slplsEDIaA................GhsshhRtGplpHp-.YhQsGKGRDlGhspI..F.psKlusG.GEQhLSR-hahlup.hsh.Rhhohaas.p.GFa..hsshh.h.hsl.h..ahh..hhh.lss.lttt...................................................................h....hh.lhhh.hlPhhht.hhEpGhhpuh.phhh..hphushF.sF.hthhsp.h.psl.hGGAcYhuTGRGFsh.+..Fs...Yphautsphh.hu.c..h....h.h...l..l.hh.h...............................................a....hh..W...h....h....shhhu.PahaNPptFta.chh.Dappa.pWh.......s............tpo.....W.......taht.................................................................................................................................................................................................t..........................................................................................................................	0	149	330	444
+2719	PF02685	Glucokinase		Glucokinase	Bashton M, Bateman A	anon	COG0837	Family	This is a family of glucokinases or glucose kinases EC:2.7.1.2. These enzymes phosphorylate glucose using ATP as a donor to give glucose-6-phosphate and ADP.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.86	0.70	-5.65	41	1646	2012-10-02 23:34:14	2003-04-07 12:59:11	11	5	1468	6	393	2092	1039	301.90	40	91.50	CHANGED	LsuDIGGTpsRhuLhsssssp.........phpsasss-asolpshlppaLtt....ptshpp.............st....uslAlAG.Plssspsph.TNhsWslShpphppsLGls..slpllNDFsAhAhAlsh.Lsppclhplsuup......sp.....ssushullGsGTGLGlutLlhsssphh.sLsuEGGHs-FuPpsscEhtlhpaLcpch..u+VSsER.lLSGsGLsslYculsphc......shpsth..............tpsusIoptAL......sussshucpsLclFsshhGshAGsLALphsAhGGVYluGGIsP+llphlppSsFtptFpsKGRhps.hlpsIPVhllhpspsGLlGAushh.pph	......................................................................................................................LluDlGGTNARhALtsh...sssp...........................pph..c.s....a....s....s....h...D....a..s.o.......L.........ps....s...l....c...h....YLpp.......php...s.p.s........................................usl.Al.....A...s...P...l........s.....G.........D....h...l...t..h.....T...N.....p...s.....W.....s.....h...S.....h.....t.....p.h.p.p....s.....L.....G...h...s.....clpll..ND.F.sA.hu.h.Al.s.h....L.p.....p.....c.....c.....l.....hp..l.G.G...u.p...............s.h..............ts.t.s.h....uVhG..s....G.TGLGVAtL..l..p.....s....s..c....p.......a..l.....sL..PuEGGHlD......F......A......P......p..o......-......c......E..h..h..l.h.p.h.L......+tch..........GH...V.........S.u.ER..lL.SG.s.G.....Ls.s.LY.c.A.lsptc....................sh.h.spt...........................hpPt-I....T.p....t....AL..............ss.sss...spcsLslFCshhGphuGsL..A.L.....s..hGs.....h.....G.G.VY.luGGIlP.....R..hl.-....h.h...c.....s...S...s....F.R.stF....c.c...K..G...R..ap.s.alpsI.P.Val.l...h.p.s.p...sGLlGuushhp..s........................................................................................................................................................................	0	133	258	329
+2720	PF01182	Glucosamine_iso		Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.56	0.71	-4.59	317	6449	2012-10-04 00:26:15	2003-04-07 12:59:11	15	20	4109	64	1532	4440	1070	196.50	27	73.82	CHANGED	lspshAptlhpthppul.....tp...c.......up.hslsLoGGooPthlact..Lst...............................l..sW.....s+lplahuDERh.VP.scs-SNhths+ctLLs...ph....t.ls.......s.pla...h...............................................puAttYp.pplpphh....................................................FDllLLGhGsDGHTASLFPs..pst.h...t.....t.p..hlsslpts.Ppsss.......RlTLThsslss.A+plhhllsG.tsKtpslcp.shs	.............................................................h....huphhsph.l....t..hh..t.p...p.............................sp..hsL.uLu.sGuoPh.shY.ct..Lsp...h....t................................tl..sa..pp.lpsathDE......h......s...l....s.t..c......c.......s.p.Sh.t.t.h.hpcp.l..hspl...............s..ltt.......p..plp..hhs....u..st............................................shcspsppYc..p.tlpp.hs.t............................................................................................lDlhl...L.GlGs..D.GHl.....u......h......N......Pu.......osh.s.................p.t.......t.p...........tsst.h....h....p......s.....s......s.........csPpp..............t.l.....ThG..l...s.s.l...hp.A+clhll.stG.p...pKApAlpphl.p................................................................................	0	481	916	1262
+2721	PF00462	Glutaredoxin	glutaredoxin; 	Glutaredoxin	Finn RD, Bateman A	anon	Prosite & Pfam-B_3081 (Release 8.0)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.03	0.72	-3.98	279	11246	2012-10-03 14:45:55	2003-04-07 12:59:11	19	92	4174	90	3561	10294	5112	62.30	25	45.51	CHANGED	Vhlas+.....stCsaCppscplL....cphs..lt....a.phlclsps..t...phpptltphs............sh.TlPpla...l.sGc.hl	.......................lhlas+..........ssC.s.a.C....t....ps....+phL.............pp..pG......lp...........a..p.l..s.lpps...s................phc.p.t.lt.phs..................sh..T..l..Pp..la...l..ssphl............................................................	0	1009	2074	2907
+2722	PF04399	Glutaredoxin2_C		Glutaredoxin 2, C terminal domain	Kerrison ND	anon	COG2999	Domain	Glutaredoxins are a multifunctional family of glutathione-dependent disulphide oxidoreductases.  Unlike other glutaredoxins, glutaredoxin 2 (Grx2) cannot reduce ribonucleotide reductase.  Grx2 has significantly higher catalytic activity in the reduction of mixed disulphides with glutathione (GSH) compared with other glutaredoxins. The active site residues (Cys9-Pro10-Tyr11-Cys12, in Escherichia coli Grx2, Swiss:P39811), which are found at the interface between the N- and C-terminal domains are identical to other glutaredoxins, but there is no other similarity between glutaredoxin 2 and other glutaredoxins. Grx2 is structurally similar to glutathione-S-transferases (GST), but there is no obvious sequence similarity. The inter-domain contacts are mainly hydrophobic, suggesting that the two domains are unlikely to be stable on their own.  Both domains are needed for correct folding and activity of Grx2. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with GSH in cellular redox regulation including the response to oxidative stress.	25.40	25.40	27.40	26.30	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.31	0.71	-4.57	23	734	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	698	2	76	308	10	128.90	53	61.06	CHANGED	scltsWl+cssshhspLlhPRasphsLsEFuTtsAppaFppKKEstlG.sFsptLscosphlpplsstLppLssLlt.ssptsNt.pLohDDIhLFPhLRsLTlV+GlpaPscVpsYlcphuptopVsLh.sshAl	..............PAIE-WLRKVsGYsNKLLLPRFAKu..u.FcE..FuT....PuARcYFlcKKE...ASsG.sFsshLA+Ss.uLIKpIucDL+tLD+LIl..pPNAVNG..ELSpDDIpLFPLLRNLTLVAGI.pWPo+VADYRDNMAKpTQINLLoohAl..........	0	19	32	56
+2723	PF03157	Glutenin_hmw		High molecular weight glutenin subunit	Mifsud W	anon	Pfam-B_2180 (release 6.5)	Family	Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues.  High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterised by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm [see 1, fig.2].	30.00	30.00	30.20	30.00	29.60	29.90	hmmbuild  -o /dev/null HMM SEED	772	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.86	0.70	-15.05	0.70	-6.26	2	1571	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	61	0	1	1570	0	130.40	21	95.07	CHANGED	S.VAtQYEQplVsPKGGSFYPGETTP.QQLQQtIFWGhs.thlptYYPSVTSPpQsSYYPGQASPQpPGQGQQPGphQpsGQGQQhYYPTS.QQPGQhQQ.tpGp.GYYPTS......LQQPuQGQQ.GQGQQG.........YYPTSsQhp.GQhQQPsQGQ...Q.GQGQ...QPtQGQQPGQhQQG..P...ppP......QQLGQGQQ...PsphQQSGQGQ.GaYPTSLQQ.GQGQpGaY.sS...................QQ........QPuQGQQGp.PuptQQPGQGQ.GaYPsS.QQsGQGQ.GaYPsS.....Q.QpPGQGQQGQ..........PuptQQPGQGQ.GaYPsS.LQp..GQ.GaY.TS.QQ.GQGQQ.GQ......GQK.QQPGQGQQsGQG...QQP...pQtQQPGQGQ.GYYPTS.QQsGQGQ.....QQ.GQGQ.GYYPTS..QPGQGQ.Ga.PsS.QQPGQGQ..........GQ.GQp..................................QQPGQGQpP...pQGQQPGQGQQG...............YYPTSPQ..................QPGQGQ.........QLGQGQQGYYPTS.QQPGQGQQPG......QGQpGahPhSPQ.o......GQGQp.GQh.QPGQGQQGYYPTS.QQsGQGQQ.GQh.QsGQGpQ...P......GQGQQSGQtpQGY.SsYHVSsEpQAAS.hVAKAQQ.AsQLPshCRhEGGDALSASQ	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+2724	PF00745	GlutR_dimer	GlutR; 	Glutamyl-tRNAGlu reductase, dimerisation domain	Bateman A, Finn RD	anon	Pfam-B_544 (release 2.1)	Domain	\N	22.90	22.90	23.40	23.20	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.10	0.72	-4.07	164	2994	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	2895	1	730	2124	424	100.40	27	23.41	CHANGED	tpAEtIIp...pcsppFhphhcsh.p....ssPsIpslRppucpl+cpElc+uhpp...ht....hsccs.ccslcphscplssKllHsPstpL+p.su.tpsc..pph.....lphlpplFs..l.....c	....................pAcpIls...pEsppFhpWlcsh.p........ssssI+slRppAcplppcplp+shpp..ht..........hup.cs....cpllpc.hscplsN+llHsPotpL+phu.pc...sc....sph......lphlpplasL.....................	0	231	487	639
+2725	PF05201	GlutR_N		Glutamyl-tRNAGlu reductase, N-terminal domain	Finn RD	anon	Manual	Domain	\N	21.50	21.50	22.70	22.50	20.40	21.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.89	0.71	-4.63	172	3200	2009-09-11 08:11:09	2003-04-07 12:59:11	10	10	3083	1	803	2306	768	149.10	37	35.09	CHANGED	lGlsH+sAslclRE+luhss.pphtp..hht.pl.tt..slp....EsllLSTCNRsElY....h..ssp.................h............................phlsp.htt.ls...hp.p.lppthhhhp...spcAlcHLa+VAuGLD....ShVlGEsQILGQlKpAaphAp.....ctsssuthLpplFppAhpsuK+VRo-Ts	.............................................lGlsH+TAsVslRE+lu.Fss...splpp........ulp.pL....h.......p......p.......t....lp......................Es.ll.LSTCNRoElY.........s.....ssc..p...................psttp...t.lh.....................................................caLuc.hpt..ls.............hc.-..lptp.l.a.h.hp.s.s-Al.cHLhRVAuGLD........ShVLG.....EsQILGQlKcAathAp..........c.sts..s.u....shLp+LFppuhssAKRVRoETt.........................	0	265	544	705
+2726	PF02595	Gly_kinase	DUF168; 	Glycerate kinase family	Mian N, Bateman A	anon	COG1929	Family	This is family of Glycerate kinases.	20.20	20.20	20.20	20.30	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.13	0.70	-5.76	6	4076	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	2802	4	574	2648	422	345.30	42	97.58	CHANGED	MKIlIAPDSFKESLSAhEsApAIcpGFcplFP-AsYlslPlADGGEGTV-ullsATpGphhchcVsGPLG-p.VsAhaGhsGDG+TAlIEMAAASGLtLV..Ps-KRNPLlsTShGTGELIttAL-sGAcpIIlGIGGSATNDGGhGMlQALGsphLDusGptlGhGGusLuplAcI-lssLDsRLtpsplcVACDVsNPLsGspGAutVFGPQKGAossMVppLDpsLuHaAcllccssGhslpshsGAGAAGGMGuuLhshLssclKuGIpIVhctlpLtptlpDA-LVITGEGRIDuQSlpGKsPlGVApsAKpashPVIuIAGslscDhsVVapaGIDAlFSIlsthusLc-ALpputssLhpsApslAssLthuts	.....................................................................................................................MKlVIAPDSFK-SLoA.psupAIcp.Gh..................p......p......l.h..............P......c....A..........p.................h.......l....p......lPlADGGEGTl-.u.hh....t..A.............s....t......G...p.....h.......h....p...h.p......V.suP....h.Gct....l..............p........A...h.......a..G..h..............................s...............c.....s...........p..........T.......A.....lIEMAsAuGLp..Ll.....s.........p...........p...R.....sP.....L.h....s...o..o.hGs....GELItp..AL.c.p....G.......s.c.c..............I.llGlGGSATNDGGsGMhpAL.Gs....c..h..h...........Dt.pG............p...........l..s..........s...............G.us.L.t.....p...lsp.ID...h.........s.t...h..........c...s.....+....L.......p.......p...s.......pl.pl..As..DVs..NPLsGtp.GA.o.tl...FG..P...QK.........G.........As........p..h.l.tp....LDps..Lppa.uc.ll....p.....p........t...................h..................t.................h................s.......l..............t.....p..........hs..G.uGAAGGhGuuLhu.a..h........s........A........plpsGI-lVhc....h....h....pLcptl...p.....s.......A......D......L..VITGEGR.lDpQohh.G..KsPlGV.A.p.hA..+..p..h.....p.....h..P.V..Iuls..Gs..l..s.c..s...h....t........h......lh..p...t.G........l.s.AsFul...l......t......h......sLpcs..h..p..p..u..t..p..pl....p..s.u.psluthh....t.............................................	0	175	336	474
+2727	PF01228	Gly_radical		Glycine radical	Finn RD, Bateman A	anon	Prosite	Domain	\N	22.20	22.20	22.20	22.80	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.25	0.72	-3.68	141	5415	2012-10-01 23:28:04	2003-04-07 12:59:11	16	8	2388	24	579	3783	69	105.20	42	16.10	CHANGED	husGssPhpG.....tDtpGshAsl.sS..luKlsa.thtpsGhhhshp..hssssl...p.........p.cpthpslsshlcs........aa......p.......................sGhHl.phNVls+.......csLh-AtccPEc..Y.sLslRVuGYus.pFs	............................................................usGusPhpG.....tDppGsh.A.sL.sS...VuKL............sh..sh..sps..G..l....h.shp...lsPs.sLst..p...........s.-sphppL..ssll-u..........aF...c........................GGpHl.NlNVhsR...........EsLhDAhc.......H..PEc..YspLslRVSGYuVpFs....................................	0	177	347	474
+2728	PF00232	Glyco_hydro_1	glycosyl_hydro1; 	Glycosyl hydrolase family 1	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	455	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.66	0.70	-6.29	13	11445	2012-10-03 05:44:19	2003-04-07 12:59:11	13	39	2849	314	2628	8499	1126	399.30	33	95.89	CHANGED	hptsFPccFlWGsATAAYQIEGAapcDG+G.SlWD.....sFs+p.Ps+shssps.GDlACDpYHRaccDlpLhpclGhpsYRFSluWsRIhPpG..sGtlNptGLcaYc+LlDtLhppGIpPhlTLaHWDLPQsLpD.tGGWts...RsslctFpcYAcssFccFGD+VKhWlTaNEPhssuhhuatsGhauPG..............hpshpssapsuHplLlAHAcul+ha+-hh....sGpIGlslssshthPhosus.-s.cAu-RthpatssWFh-Plh+.GcYPpphhchhtcp........uhhsshs-pDhcll...psshDFlGlNYYoophhpsps.....psh.s.spshthspts................oshuW.hh.P.GL+cLLphlpccYsp..hsIYITENGhuhpDch.p.....uplpDstRIsYlppHLspltcAI.pDGlsl+GYhsWSLhDNFEWspG.YscRFGllaVs.....hsoppRpsKcSuhWYppllpsNGh	.............................................................................h...thPpsFlWGuAsu..A.Q.........hE..G....u..h..p......t...s...G...+..G.............s.h...h.D..................................h.h.h.......p...................t..............t.......h........h............t....t...........................................sc.................u........D...a.Y.........c..+..Y..c........-...................D.lt.Lh.t.......c..hG...hpsaRhSIu....W.........oRl.....h...P..........p.........G..............p...s.......p......s..............N..p...tG.lpFYcplh-c.....h...h.p.h..................s..Ic.PhlTL..............H.......a.....-.h.P.............................t.............L.......................p.....h.................G...........G.Wh.s...........+.c..h.l........c....hFhca.Ac..............hsFppat....c+.........V.........+aWhTaN.E..........s............h..........h.......s.......a.......h......h.......u.......h....h.......ss...........................................tt.s.....p..t.ha...p.s..h....H....p...hlApAhA.........schh...+ph............................ps.p...lGhhl.s.h..s..........h.......YP......h.s....s....p..s......t....-....h.............A....t..........p...................h....................p.......t......h.......h...........................h...........a....h......D..s..........h.........t..G.p.Y.P..t...h..hphhp.cp................................s.h.....p..h..p..t..tD....h.p.h.l................p.s...s...sDaluhsYYhst.hs.p.st.....................................t.............t...s....t........h.....t..h...............................s.s..h..h......t..o.....p....h......s.W.t.I.....P......G..l...h..hl..p...l.hcc.......Yt......hsl.alsE..N........G...................h...G.s......-..p....t.......................tstl.p.Ds.h.RIp..YlppHl.p.thtc......A................l.....t.....-G.ssl.hGYhsWu.h........h......D.......h................Sh.s.s..G..hp.c.R..YGhl..aVD................sshpRh..K.cSh....h....WYpplltspt.t.................................................................................................................................	2	642	1346	1995
+2729	PF00331	Glyco_hydro_10	glycosyl_hydro3; 	Glycosyl hydrolase family 10	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.41	54	2356	2012-10-03 05:44:19	2003-04-07 12:59:11	15	132	632	164	770	2484	350	243.90	30	61.72	CHANGED	oLcphhpsph..hhGsAlsts......hhst....ppttllp..pcFNplTsENpMKh-ulpsscG..........................pFsFssADplVsaAppNshtlRGHTLVWHs..QhP....sWhtp.....sss.ss..............LhptlcsHIpsVhs+YK.......plhuWDVVNEshs-ss..........thRp.......SsahplhG........p-alchAFphARcADP......sAKLahNDYNh-ps.....sK.spslhshV+chp.scGlP.......IDGlGhQsHlsssts...........splppulptauslG...h-ltITELDlps.t.................................tpApcYpplhphhhp........phsulThWGlsDstSWhss.............................stPLLFDssapsKPAY.ullssh	.................................................................................................................................thh......t....a.s..hs..tNthK........hts..t..s............................h...s..a.t.......s...-..h..ht....hs.t......tp...s.......h........h.+...uH...sl.....h.....W.ts......p...s.............t..Wh.t............t..t...................................................hht.....hh.p.pal..ps.l.ht+.at................hhs...WDVV..N.Eslssss.....................shR.p.................................o.h..a.hp...hhG...............p-a...lt...hA..FchA+....psDP.......................sApL.......ah......N......D....Y.Nhpps.........sK...ppth..h...p.hl.c.p..lp.......p..p.G.ls....................I.D..G......lG.h..Q.....uH.h..........................t.h....t.t...hpt.h.s........t...........h......s...h.l.hTEh....Dlt........................................................st...htthh.t..hht....................h.slhhWsh.p..................hh.t...................................h...............................h............................................................................................................................................................................	0	311	563	699
+2730	PF00457	Glyco_hydro_11	glycosyl_hydro6; 	Glycosyl hydrolases family 11	Finn RD	anon	Prosite	Domain	\N	21.60	21.60	22.70	22.70	19.30	21.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.50	0.71	-4.95	12	815	2012-10-02 19:29:29	2003-04-07 12:59:11	12	49	338	104	256	868	0	165.60	49	64.32	CHANGED	GssuGhaYphWsDsGussshhss.GGsaSssWs..NtGNhVsGKGWssGo........sshslsYsusas.PsGNSYLsVYGWTpsPLlEYYIV-saGoYcPsus.spthsoVsusGuTYDIapTTRhNpPSIpG.TsTFpQYWSVRpoKRosG........TlosssHFsAWtptGMshG.phhYplhAsEGYpSSGSAslsl	............................tsshaaphWp.D.ss..u...s...s.p.....h......s...........s...........uG..paospWs.....s.s..uNalsGKGWpsGs..................................tpslsY...s...u...s.ap......ssG...N....u....YLulYGW.......T.p......s........P........L.......lEYYIVEsa......Go.Yp....P......su......s....sp..............h.GoV....ooDG.uTY-IYposRhN.tPS..I..p..G...TsT.FpQYWSVRps...K.Rs..tG.............olohu...sHFsAWtp..hG........hp...lG....sh...a..hlss...E.G..Yp....S.SGsusls..............................................	1	85	169	226
+2731	PF01109	GM_CSF		Granulocyte-macrophage colony-stimulating factor	Bateman A	anon	Sarah Teichmann	Domain	\N	20.10	20.10	20.10	21.20	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.63	0.71	-4.17	7	64	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	42	5	16	68	0	118.90	55	84.06	CHANGED	APTRsPssVTRPWpHVDA.IpEALSLLNpopDssAsMNc.sV-VVS-.F-.QcPTClQTRLpLYKpGLRGsLT+LcGsLTMhAsHYcpHCPPTPETsCtTQhITFcsFK-sLKcFLFsIPFDCW	...............................APT+.PussTpP.WpHV-A.IpEAhpLLN.SpDssA.MNc.sVEVVSEhFD.QEPTCLQTRLcLYcpGL+GSLTcLcGsLTMMAoHY+.........pHCPPTPETSCtTQhITFcSFKEsLKcFLh.IPFDCW........	1	1	1	2
+2732	PF01670	Glyco_hydro_12		Glycosyl hydrolase family 12	Bateman A	anon	Pfam-B_1736 (release 4.1)	Family	\N	20.80	20.80	24.10	23.40	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.44	12	532	2012-10-02 19:29:29	2003-04-07 12:59:11	11	21	280	62	289	492	9	154.30	26	54.07	CHANGED	.spsl.hhVuslpShsoslsauh.ssosl.sssAYDlahssss..pssusGchElMIWhsphGslpPhGspluTsol....sGp....oW-lWhG.....hsus.psauaVssoshsshphDV+cFhchhspspuh......stsshYlpshphGTE.ass.....ssshslssaSssVp	.............................................htluslpo..hsosh..pa..sh....sss...slh.s.ssAYDlahs.....s.s.s..............t.....s....u..s.s.p....hElMlWlst...hG......s......h...t...P......l...........G......s.................l.....u......s.s.sl...................uGp..............sap..lapG..........s.s.u.sh.pVa.....o.a.l.........s......s..........s...s....h........s...sas.s.........D.....l.........ts.....F...ls........h..ts..s.p.sh............sss..YLs..........slphGsEs.asu.......ssshss..sp..aohtl.............................................................................	0	99	184	259
+2733	PF01373	Glyco_hydro_14	Glycosyl_hydr22; 	Glycosyl hydrolase family 14	Bateman A	anon	SCOP	Domain	This family are beta amylases.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.45	0.70	-5.73	5	548	2012-10-03 05:44:19	2003-04-07 12:59:11	12	11	191	66	172	752	23	308.80	44	78.16	CHANGED	aVMGPLcKV...TDWN...oFKsQLpTLKNNGVYAITTDlWWGYVEsAGDNQFDWSYYKTYAsoVKpAGLKWVPIISTHpCGGNVGDDCNIPLPSWVWoKsSsD.-MQFKDESGpsNsEuLS......PlaSGls..KpYsELYuSFApNFuuYK.DlIsKIYLSGGPSGELRYPSYsPSsG.WoYPGRGKFQsYTEsAKSuFRsAMpsKYGSLsKlNuAWGTsLTShS..QIsPPTDGDsFaTNGsYNSsYGKDFLoWYQSVLENHLulIGuuAHssFDsVFGV+IGAKIAGlHWQYNNPTMPHuAEpsAGYYD......Ys+LlcpFKcucLDLTFTCLEMsDS..GouPpYS..hPpTLVcsVuolANsKGlcLNGENALspGsSu.tFp+ltEclTsauauG.....FTLLRlNNlVNsDGSsTuEMusF	...........................................................................................................................................................................................................lhSFHpC.GG.NVGD.s......ssIP.lPpW.Vh-h...s.....tp..........s.sDlhaTs.....+.....t.....Gp...RNhEhLohGs..............Dp.Plh.......p.GRTslphYsDaMtSFRps.h.pp..a.h...su......sIs-IpVGhG..PuGE..hRY..PSY.P..p......u.p....G...W...h....a.................P.G.....l..GE....F........C...YDKYhpush.+sAAt.....................Wth.....s.....s.....s..s..st......YNshP....c..c..T.t....F.F...p..p........s....G....s...a...oph...G..+....FFLsWYSshLlpHGD+lLstA.p..pl.......F............u.....s........t.................Vp..l.uh..Kl.......uGIH.WaYp....s.sHssEhsuGahs.......................Y..lh...thh..tp..........t.......h.h.hss..h..-...hp..s.................s.....PptLl.plh..s...t...h.h....tsEN..u.....h.....h.....s...th.......tph...................................................hsh.ph..................................................................................................................	1	48	111	143
+2734	PF00723	Glyco_hydro_15	glycosyl_hydr10;	Glycosyl hydrolases family 15	Bateman A	anon	Pfam-B_771 (release 2.1)	Family	In higher organisms this family is represented by phosphorylase kinase subunits.	21.70	21.70	21.80	21.70	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.47	0.70	-5.93	26	2515	2012-10-03 02:33:51	2003-04-07 12:59:11	16	24	1317	16	1160	2459	281	390.30	19	61.49	CHANGED	uhttpthhpslts.thhh.ss.oGhllASsopotP..........DYhasWsRDuuhshtulh...............ctht.thppsltphhcs.hlps.hphputsps.sphpss...sLttstapsstsshsGs..WG+.QhDusuhhhhslhph......htsG..........thpssl..l...lps.lpYlsptWsps..saslWE....pppupp.a..opsstt+AllcuhshActhG..s.................................................ssph..hppptsplhspl.......p....ua..........................Wssttsahthsss....................ppsLDush..............lLhshhsasssss...................s+hlushhhlhss.hpsthhlssu..ts........ltR.YspDsh....................................................................t.ht.sGsPa.................................................aLsohh......................................................................................................................................................................................................................................................................................................sp.hhstlhthsuptt.htlschuhshacchsss.................su...p....pt.h.sh..s.tthss.hhphht..ssssGhLuEphsh..........hpGp..huupshsaSasshlpsuh	...................................................................................................................................................................................................h......h.p....hh..hh.h.hh....ts.sGsll.A..u.so....tshs....................cYph.sWlRDushshh..ulhthu............................tp..th.h....h.h..........tp....s.....h........h.........t....................p.....t............lp....hht..h.tsp..p.h...tp........................hh...thts.s...t.......s.s......h..h..G..s.......t......hsphQhDs.hu.hh..h.l.hth.................................hpts.......................hth.tp...h.th..........l.pt....h....l....ta....l.......t......p......t......a...p......t......s........D...GlWE.........pts.p.ph...Splhhh.hA...h.c....uhp..h.h.p.h.h.s.....ts........................................................................................................h.ph.....hpt..ht.pp.lhppl.............hpp..........ua...............................................................................................................................................................s.........h..h.a...h.t.h.ss.........................................ptlDush.......................................................................................lhhs....h..t...h.h.ss.s...c......................................................sphhs.sh.h.l.tp.....L.....h..t....t.t...h.................................................hhR..Y.....t.p.............................................................................................h.........t..ttsa.......................................................................................................................................................................................................hh.sshh.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	366	666	954
+2735	PF00332	Glyco_hydro_17	glycosyl_hydro4; 	Glycosyl hydrolases family 17	Finn RD	anon	Prosite	Domain	\N	24.00	24.00	24.10	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.10	0.70	-5.39	16	2142	2012-10-03 05:44:19	2003-04-07 12:59:11	13	28	364	18	1056	2132	103	250.50	30	66.00	CHANGED	IGVCYGhhuNNLPuss-VVpLY+opsIpcMRlYpscspsLpAL+GSsIpllLsls.NssLtsLAus.otAssWVpsNV+saass.Vph+YIAVGNEVssusspu.....llPAMcNlpsALsAAGLuspIKVoTulphsllsNoaPPSsGsFpsssh..hlsPllpaLssssuPLLsNlYPYFuausNPt.slpLsYAhFpssssss.Ds..uhsYpNLFDAhlDulYuAl-KsGus.slclVVSESGWPSsGu...huAoh-NApsYspNLIsHVt....tGTP++PG.slETYlFAMFsENpKssc.....lE+HFGLFpPscpPtYslsF	..............................................................................................................................................................................................................GhshG.......s..p....s.ttsht.h.h.pt.....t.h..t..th+la.t.ss....thlpuh.t..s.o..sltlh...lsls.s.t...l..t.hss.............t....At.tWl..p.p..s....l.....a...........................s........p......hp.......hls.V.G.NE....h.......t.s.tt................llsAhp..slpt.u.....l..t.....h...s.l..t......tlp.......loss..h.t.h.shh...t....t...s.......s....P...St.u..Fp.th....hhtshh..pa.Ltps..s..u.P...hhhN.h...YPahuh....h.......s.s.......h.s.l.saAhFp....s.....s......s..........s.....h.....Ds...................tht.YpNhhD.A.lDuhhsAh...p...t..............h.....Gh.........s....s............l.............p................lll................uEoGWPo...tGs...............su..s.......h.t...s......A......t.sasps..Ll..p.+.lt....................pG....T..Ph....p......P.s....sl.....p.....sYl.F.uhFsE....s..K.....s.....ss..........sE+p.aGlF...s.s..t.p..hY.l.............................................	0	163	606	854
+2736	PF00182	Glyco_hydro_19	chitinase_1; 	Chitinase class I	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	20.50	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.61	0.70	-4.69	17	2104	2012-10-03 00:09:25	2003-04-07 12:59:11	14	48	920	28	497	2044	184	174.20	31	58.88	CHANGED	IlopuhF-pMLpaRNssuCsuKGFYTYDAFlsAApuFPuFGso.GDsss+KREIAAFhAQTSHEToGthhhus-usauWGYCahpp...........sptpaPCusG+cYaGRGPIQLoaNYNYG.AGp..AIG.DLLssPDLVuoDsslSFKTAlWFWMTsQss.KPSsHsVIsupWpPSssDtuAsRlPGaGsITNIINGGlECspG.psspspsRIGFY+RYCshLGVssGsNLcC	............................................................................................................................................a...shtthh.tAh..t......a.......t......h.s.....t................s...........t......................t.....++pl....As.hhu.phspE.Ts....t...h........h.......h..t.....................s.......h..................t............................s..................hs....................................................h......................p....t....p.....h............s........s......s.......s.....G.....p.....p.....Y..a...GR.G......slQ.loapa.....N....Ys...ss.....Gc............u...l......u....h......D.........L........L........s.s.......P-......l......V..up.........D....sh......l......uhpoAl.WFW......hss..........................htsh......t...............................G.................a..G..hhphl.Nss.pCs......................t..........t....pl....tha..hht.....................................................................................	0	116	292	404
+2737	PF00703	Glyco_hydro_2	glycosyl_hydro7;	Glycosyl hydrolases family 2	Bateman A, Griffiths-Jones SR	anon	Pfam-B_572 (release 2.1)	Domain	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.59	0.72	-3.61	136	6352	2010-01-08 13:56:32	2003-04-07 12:59:11	16	146	2285	323	1491	5735	464	105.70	19	11.70	CHANGED	spl.p...s........hhlpsphsp....ppuplplpl..............hpstsstshphplpsphhssstpphtt..sstthhhhttt.......................h.h.ps..pLWss....c.p..Pp.LY..slplpl.....tss.....phh-ph..ppphGhR	.....................................................................................l..t...s............hh.l.t.s.p.hspt.......ppuplph..pl......................s........t...t...t.....s.....t...p.....h....p....l...p..h...p......l....h.....s.sp.s.....p.hs.ss.........sptths...................................................................ph.pl.p.sP.....cLWss.......-p.P.h.LY..pltlpl........tss...............phl..-th...spphGhR......................................	0	531	1045	1312
+2738	PF00728	Glyco_hydro_20	glycosyl_hydr11; 	Glycosyl hydrolase family 20, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_877 (release 2.1)	Domain	This domain has a TIM barrel fold.	20.60	20.60	20.60	20.70	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.32	0.70	-5.29	56	4091	2012-10-03 05:44:19	2003-04-07 12:59:11	17	134	1587	80	1175	3510	693	323.90	22	49.19	CHANGED	FsaRGhhlDsuR.pFhshcplc+hIDtMAhhKhNphHhHLoDs.......puWplpl.....psaPcLochGuhpspt.........................................................hYTpp-lp-llpYAttRtIcVIPEIDhPGHstusltuhsphttt.........................thphtssp.hlssspspoapFlcslhcElsphas......spalHlGGDEs...........................tspWppsst...hpthhtptt...ts..............htph.th........h.t+htphlpptGpp....hlsWs-hhpss..................................ssspshl.sWps............st.stphs.............ppGaplIhoshs...hhYlDhhtsttst..sh..............h.shpps...................hsasshhpt.s..........stptt...........tlhGspuslWsEhl.......ssspl-hhlaPRhhAlAEtsWoss	....................................................................................................................hRGhhlDsu.R.p.ah.sh.........ptlcc.hl.Dhhuh.hKhN.thHh..HlsDs...........................tu....a.t.hpl..........p.thPt.....hs.ph.....sshps.t............................................................................................................t.hYTpp-hp-llpY....A.pp+................sIpllPEI-hP............GH......hp......u......h..l..tu..h.sc..hhtt.......................................................................tht.h.ts......t.......t..hls.....s...p.p.p.sh.p.Flc.sll......s-l..h....p..h.Fs...................sphhHlGuDEs................................tss.a..tt.s.....t.....hpthht..p...t......s..........................tpl..s.h........a.h...p..cl......t..p.h....l......p....p.....p...Ghp.......hhsW..s-.hhhtt...............................................sps....s..h....l..hWps......................ttshphs....................................................................pp.G.a..ch.....l....ss.p........hhYh.shhtt...................................................................pth..............................................................................................ph.ps.h..t..t.......................p.....................................lhGs.ss.hWs-..hh................stp.......h...p....hhaP...p...h.uh.AEh.Wp..t.........................................................................................................................	1	455	732	999
+2739	PF02838	Glyco_hydro_20b	glycosyl_hydr11; 	Glycosyl hydrolase family 20, domain 2	Bateman A, Griffiths-Jones SR	anon	Pfam-B_877 (release 2.1)	Domain	This domain has a zincin-like fold.	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.78	0.71	-3.58	143	2321	2012-10-01 20:56:08	2003-04-07 12:59:11	10	128	932	72	547	2311	319	127.00	21	15.90	CHANGED	ph.sllPtPppl..p.h..tsGs....asls..s.s.sslsh..ss....ts....pt..s.....s....p.h.Lpph.l.p.......ttG.h..phs........tss..sss.........p...ssl..............t.......ts...................thhspEuYtLs.lss....s.....slsltussssGhFaGhpTLtQll..ttt...........ttt........pl..s.ss.pIpDa	.......................................................................................................tllPtPp..pl..p.h...tpGp.....hs.l...........s....p..s..splsh..ss...........t.......tps...............s......p.hL.tph..lp...........hhGh....pht...............ss.tss..............p.ssl.......................h..........s.............................................................sth.ssE...uYpLs...lss....p.........tlplpus.s.ss.GhFaulQTLhQLl..sst..............................ttt...........pl...P..ss..pIpD.............................................	0	198	366	481
+2740	PF01183	Glyco_hydro_25	Glycosyl_hydr18;	Glycosyl hydrolases family 25	Finn RD, Bateman A	anon	Prosite	Family	\N	27.00	27.00	27.00	27.70	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.41	0.71	-4.46	28	3628	2012-10-03 05:44:19	2003-04-07 12:59:11	15	150	2015	18	613	2804	137	177.30	24	50.67	CHANGED	lDVSpaQusls...aspl.....ppsGl..phshlKATEGssahsshhspphssucssGlhhusYHFhp.s...ssAtppAcaFlssl...thssssh..sLDhE..............tphssstpssssthppFlcpl.cpptGh+sll.YosssFhpsp...hsph.spa..sLWlApYsspssss..........shsshshWQYTusG.hsGl	..............................................lDl.SpaQ....u....p.ls........appl.......................t.psG.h........pashl......+.....s......o......c.......G...........s.........s........h...........h...D....s...t...........app...php..p....upp....t......G...l...h.G.sYaasps.................ss......u.pppA.c..h...Flpps...............shs.ttsh..........s..lDlE.................................t.s.hst.sshpp.tl.p...s...ahspl...p.....p......t...s.....G.....h...p..s.h.l...Yos...t.s...ahpp...p.......................t........s...p.h........sph..............slW.lAp..Y.ssp....s.h...........................ts..hsh.WQaospGphsG....................................................................	0	217	409	506
+2741	PF02156	Glyco_hydro_26		Glycosyl hydrolase family 26	Mian N, Bateman A	anon	IPR000805	Family	\N	20.20	20.20	20.20	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.19	0.70	-4.95	8	834	2012-10-03 05:44:19	2003-04-07 12:59:11	10	61	453	23	298	816	38	238.10	19	51.41	CHANGED	VsPNAptss+sLhsaLsslhs...++lLSGph....Guhs.sshshp-hpplpssTG+hPAlhuhDahc..hosupltcshsssss.p-hIsaW+..pG.GIlslshHas.......sPup..pts.sFhTtsTo.phcsslsss.osEY+.hlhc.lDpIA-tLpcLQsps...VPVLFRPLHEssGcWFWWGscG........PcsYKpLW+hlY-hhsch+GLsNLIWVYosss..s.tssa....YPGDsYVDIlGhDsYts..Dstshos.asphlsLhsutthstluE....sGolP.sthIsshchpas...aF.sWss.........phshsssptlpclapssaVls+DE	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h....t...l.s...t.h....tp.l.p..s......s........lPlla.R.hHEh.........s........G....s............W..F...WW..G..t.p....................sptahp..ha+h...hhch.hp..pt....p.sl.....s.Nll.a....s.....a......s......s......s....s..............................t........s............s.....s.....a..........YPG..D.....sYVDllGhDsYst.............s.......s........t.....t......................a..tp....h..h...t..................t....................ht..................................................................................................................................................................................................................................	0	140	222	272
+2742	PF00295	Glyco_hydro_28	PG; 	Glycosyl hydrolases family 28	Finn RD	anon	Prosite	Domain	Glycosyl hydrolase family 28 includes polygalacturonase EC:3.2.1.15 as well as rhamnogalacturonase A(RGase A), EC:3.2.1.-.  These enzymes is important in cell wall metabolism.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.09	0.70	-5.48	16	3587	2012-10-02 14:50:22	2003-04-07 12:59:11	12	63	822	30	1506	3608	74	283.30	21	67.90	CHANGED	CushshsslhVPp..shtLc.sshs......uuholphpGTsphs..........hcp.ph.....hhhlsssplsshsssG.usIDGpGs........tWWcspsp.....ssKstPphlphppsc.suplsslslpNo..hthslptssslshsclsIssssss.............NTDGhclusSsslpIssssltstDDCluIsoGo......slphTsssCusGHG..ISIGSlGspss.ssVssVsVpssslssosNGVRIKT.hp..uuoGoVoslpapNIphpsls.hsIlI-QsYps.ssPssps.souVploslsacslsGTsso.tsslhlLCucu..Cpshshsslslou.G...psoupCpNls.......ssssC	.................................................................................................................................................................................................................................................................................................................l.......h....t.h........p............h................h.........G.............u...h.....l.sG.....pGt..................................a..a.......p....................t...t............................t.................t.......P..........p..h..l.t.h........ps.p..s.hhl.p....s........l.pl..h.NuPh.a....p.h.p...h...h...t...s.p.slp.lp...slplps.s.t.ss..................................NTDGh......Dht...s.o...ps...lhIps.......................s..h.....l..p...s.........u................D..D..........Clulp...u....Gpt...........................slhlp..s..s..h..s....s.....s...G...H..G......l..ol.G...S.........sp..t...t........................................V...........p.s....l..hl.........p.....s...s....p......h....h........s..........o...........p.........s.............G..l....R........I....K.......o....h..................uts...G....h..l....ps.....lha...pslphp.........s.....l.........p..............s.......l...h.............l.......s..........t......t...........Y...........t...........s..........t.......t...................s.........t.........t...................................s..........t........h......................l.........p........s.......l.......h..........h....p....s..l...p.....u.........p.......s..t.......t..................s......h........h......s.....t.....t............h.ps.h.hpshtl...................................................sh........................................................................................................................................................................	0	359	933	1245
+2743	PF02836	Glyco_hydro_2_C	glycosyl_hydro7; 	Glycosyl hydrolases family 2, TIM barrel domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_572 (release 2.1)	Domain	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.88	0.70	-5.52	11	6947	2012-10-03 05:44:19	2003-04-07 12:59:11	12	151	2301	315	1472	6580	701	251.70	22	30.17	CHANGED	lcl+c.shhhlNGK.lhh+GVNRHEpssh+G+uhshshhlpDlpLMK.phNhNAVRTSHYPsp.caYpLCDcYGlaVlDEsslEoHGhhphhG........................sssPpW.tAhl-RhpchlpRDKNHPSlIlWSlG.NES.....suGtshcshhcahKplDPoR...sVpYEus.......s.hssphsslhhsh.uphYpc.sh.tp....lpc.lps.....................p.pKPhI.CEYuHsMGNu.GshpcYpphapph.cYQGualW-atDpul.tptss.ss....chhtaGGDFs-p.sDhpFshN..GlhhsDRsP+PuhhphKchhp.hph	....................................................................................t..t.hhl..Nsp..h..h..hp.G..h.s....h.H..p..t...t...s......h.h..G......p.s...........h..........s.....................p..........t...........hh.p.D..l..p..l..h.K...phshNulR......s....u......H......Y......P........t...s.................p.h..h...c.h.CDch.......G.lh...V....h....sE.s........s....h...........s...h...s..h...h.......ht.................................s..p..s..s....p.h.....t.....p.....s..h..h.p.c..h....pc....h..lp.Rs......+NHPSllh.WS.....lu..NEs.....................................stt.t.........h.......p.......t....h......h.......p..h.......h.......+..p....h.......D......s...o....R..............l.p.......h..t.ts.......................................................h.....t..........................s....h.................t......h.....h......t...................t........................htt............................................................................p.....s...h...h......s...E..........as..t......s.....h.........h.....s...................t...................h.....t.................................h............................................................h..............t............t.......h........h..............................t...........................................................................................................................................................................................................................h.............................................................................................................................................................................................	2	553	1041	1294
+2744	PF02837	Glyco_hydro_2_N	glycosyl_hydro7; 	Glycosyl hydrolases family 2, sugar binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_572 (release 2.1)	Domain	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.09	0.71	-4.69	88	7272	2012-10-03 19:46:52	2003-04-07 12:59:11	13	195	2374	329	1801	6677	638	164.50	21	18.74	CHANGED	ppphhsLNG.......tWpFphssss.........................t...t..h.................thss......tta.pplsVPssaphp.sh.........................................tt............sssuhYc+pFplssph.....p...scclhlpF-GVpsshhValNGphVGh.ppsuasshEaDlTshlptGc....NplsVpVh......phssusal................................s.DhaphuGIaRsVhLhspP	...............................................................................................................................................t...h..Lss........W...pFth.tts..........................................................................................t...................................................pt.....th...p.p..l..s..V..P.s..s..aphp....h...............................................................................................................sss.s.h.....Y.p+...p.F....p....l.s.p..s..h.......................p........s.p..p....l..h..L.pF.-.G...V.p...p..t.s.p.V...al.....N......G......p......h......l...........G........h......p........p..........s...u.......a.....t.....s.....h.......c.....h...D.l..T....s....h....l...........p....t...........Gp.............N..hlsVp.V.....................p......s.s.phh...................................................s.h.a............h.....u......G..IaRsVhLhh............................................................................................	0	669	1268	1576
+2745	PF00933	Glyco_hydro_3	glycosyl_hydr14;	Glycosyl hydrolase family 3 N terminal domain	Bateman A	anon	Pfam-B_1151 (release 3.0)	Family	\N	20.70	20.70	21.30	20.70	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.73	0.70	-5.44	39	9251	2012-10-03 05:44:19	2003-04-07 12:59:11	16	142	3405	47	3184	8362	2951	295.80	24	46.55	CHANGED	TL-EKls.hs....................................hhGuhhh.........................shtpssshsRlGlPtlhs.pDustGlptt.hs............TsFPsuhulu..uoastc....LhpchGthhGpEhpu......pGlslhhuPsls.lsRsPtsG.RsaEsFuEDPh.Lsuthusthl+GlQu....t........G....VhuosKHFsu....NppEspR...................pssssslsccsl+ElaLhsFptAV.cusssoVMsu...YNplNGs..............ustsphlLsplL+c-hG.....F..pGhVhSDWh...............sspssstulpAGlDhpMssshh................ppLhpulcsGp..lspppl-csspRIlph	..........................................................................................................................................................................................................................h.u.hh....................................................t.h...t.......p...t.h..h...t...............p....h...t...l.....P.h.h.hs..hD.....t.....t.......G.h.ht.thtt..................................................ThaP.....s....s..h.u........h...u.....u....o..a.....s...c.......................ls.p....p.h....G....p....h.....h.up....E...h.pu..........................hGl.sh.s.h......u.P.s.l.....s...l..........s......+.......s...s......p......h.........s....p...s................c.u.a.u....-.DPh.lsut.hut.s.hl..cGhQs.......t...............................u...l..h.us..s..K................H..F.suh........sss....-...s...p+....................................................................p.h..s...s..s..s.h...s..t..p....p..l..p...p...h........h........PF.cts.l..................c.....u....s.....s.........s.......u.........l..Msu..................a.....s......p.........l.....s..u.p..........................Pu.st.....sph.ll..pslLR..p.....c.....h..G..............F...cG.......h...l..h.S...Dhh...s....h..t...t..h.....h.................................htcs.s..h.t.ul..p.....A..G.s.Dh...h.ss...s.th............................................................ptlh...p..t..l........p...p..Gp..........l..s.....t...plspust+lh..h.........................................................................................................................	1	1038	2061	2768
+2746	PF00251	Glyco_hydro_32N	glycosyl_hydro2; Glyco_hydro_32; 	Glycosyl hydrolases family 32 N-terminal domain	Finn RD	anon	Prosite	Domain	This domain corresponds to the N-terminal domain of glycosyl hydrolase family 32 which forms a five bladed beta propeller structure [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.39	0.70	-5.06	138	4354	2012-10-02 00:26:57	2003-04-07 12:59:11	15	62	2280	59	842	3991	275	289.10	30	57.76	CHANGED	HFpP.psWhNDPNG.hY..apGhYHLFYQaNP.huss..W..G...htWGHus.ScDLlpWpcls.hAlhPs.p.aDtpG..saSGSAslhss..p..............lhhlYTGs...sp...........p...tpsQslAhsh.c.u....tpahK.....NPllh....Pss...sspcFRDPpshWhp....-.upWhhllGuppp.....ppGhshlYcS..pD..hhpW.phhsphhpss..t.....stMWECPDha.lss.p........................s.t.t.....hhhVLthS...............pssttshY.hlGp.as..psspa.ss...........s...hh....chDaGp..FYAupoFhD.....ssp.RRllhGWhu.psDtp.tsphs......cGWsu..hholPRplhL.........-..ttspLlQhP	........................................................................................................HhpP.t.s...h...hN....DPNG............hha...a.....pG.p.Y.Hl.F..Y..Q...........a..................P....h.....u.....sh....................a....G.............h...p.................W.....u..H.s....s.....S....c..D.....L..l..pW.......p..p..............h.....s.......h....A....l........h.......P...s.....p..........h.......D.....p...p.....G.............sa.SGS..Ah.........ss..p.......................................................................................lhh.hYTGpsp..............................................pt...pph...Q..s..l..Ahs....csu....................hpap.K.......................sPllht...........P.s.............tsp...cF........R......D...P........pl..............a...pt................s..sp..ah......h.l............l............G.....u.......p...........p......................p................p.........G............p..l....h....lY.p..S.....pD......l....h..p...W.p.h.h..u.t...h.h..t.sst............................uhMWE...C..PDha..lssp.........................................................................lLhhss....sht.........................pshht.s.hY...h..l..Gp....a..p.....pst..pa.sp...............................tp.ht.plD...hG.....h.-.....a.......Y.A......sp....oa.s................sss...Rpl.hhuWh....s...............-.............hs..........tpsW...t.u.sh.................olsRplpl.......ps.....spLhphP...............................................................................................................................................	0	225	502	696
+2747	PF01301	Glyco_hydro_35	Glycosyl_hydr17; 	Glycosyl hydrolases family 35	Finn RD, Bateman A	anon	Prosite	Family	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.19	0.70	-5.08	37	2284	2012-10-03 05:44:19	2003-04-07 12:59:11	14	47	1041	19	826	2224	59	273.10	34	43.63	CHANGED	shll-Gp.hhllSGulHYhRhs.PphWtDhlpKsKshGhNslpTYV.WNhHEPppGp.asFpGt.hDlscFl+hs.pctGLaVlLRsGPYICAEWshGGhPsWLhph..shphRoss.s.ahptscpahstlhshlts..LhhspG.GPIIhsQlENEYG......hss-tsYht.thschhhchsss.shhhssssPhhhshps....shss...lhssssasss...t.........h........ts.pPpp....PhhhsEaWsGWFspWGp.......hpcsspc..lAtsltchltps......u.hNhYMaHGGTNFGhhsGushhs..........TSYDYDAPlsEtGphs.sKYttl+clhpth	.............................................................................hhlsGp.hhlhSGtlHY.R...........hs....p.............W....c.....hl..ph.........K.shG......hNslpo..Y...l.........WN.......hHEP.p................Gp.....ap.F..........p..G...................hD......l.t..tFlph...A...pch.GL.a.l.l.l.R..............PGP..Y.........lC........A......EW....ph..G.G..h..P............s..WL.....h....p..............................s.......h.............p..........h.....R.................o........s...........s.................................s.............ah.....t....t...s....p...pa...........h...p........t........l........hs.h.hts..........h.h...s.........p.........G.....G.......s..ll.h.h.....Q.............lENE.YG.....................................s.-.....t..sYht....thtp.h.h.h.p.h.u...h......s..........s.....h.....hs..ss.....s....s..........hh.ps.............sh.t...........lhssssahst.....t.....................................................p......sp.t............Ph.........hh..........hE..has.G..........WastWut.................................sh....p.......p.s.s.pp........hs..s...ltch..lttt...................................s.hNhYM..................aaGG.T.N....F..G.hhsGsshh..............................TS......Y..................DYDAslsE.Gt.s.........Kahtl+phht..h........................................................................................................................................	0	254	472	661
+2748	PF01074	Glyco_hydro_38	Glycosyl_hydr16;	Glycosyl hydrolases family 38 N-terminal domain	Finn RD, Bateman A	anon	Pfam-B_731 (release 3.0)	Domain	Glycosyl hydrolases are key enzymes of carbohydrate metabolism.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.56	0.70	-5.15	50	2799	2012-10-03 16:37:10	2003-04-07 12:59:11	17	32	1483	64	926	2418	153	271.20	24	29.16	CHANGED	plasluHuHhDsuWLaslc-s.........pppspps..asol...lshhcc.s-hpF..htupsthaphhhcc.psphhpcl.+chVpcGphEhluGhWV.sDpshssh-ollcQhhhGp+ahccpFG..hpscsuWhsDsFGaSushPplhp.puGhctahhp+lsasspsph............ptpFhWcu.cu.........oclhoahhsh.............sh......ssph.............................cspsllpthpphtsptt......sspsLhshGhs.........Dsstsshcchlctlpthps.h.....hhsclphuTs.spYacslcp.........................ss-h.sas	..................................................lahlsHsHhDh..t.Whhshccp.......................chplhph.....hssl........ls.hh......c........p..p......P......-...........a.p....F.......htu.........p......s......................t...hh..c...a.h....p...........pP........c.t..........hp..cl...+......chl....p...p....G........+...lph.h...........Gshal.sDss.lsuuEuhlRphh..hGp..phh..pp.....paG.........tps......phuahPDsFG.a..suphPplhp.tsGhc..th........h....htR..h........s.....h..s...pt..sph................................p...pp.Fh...Wp.u.DG.......................ocl....hs.thhst........................hssth...........................................................phpt.h..h..p.t....h.p.ph....t.p...t.th.................s.s.p.h.lh.shGts.............................pt.t.hs.s.pp.ph..hch.hphh.pp...h..........................stsphhh.u.s..pcahptlctt.......................................................................................................................................................................................................................................................	0	336	545	754
+2749	PF01229	Glyco_hydro_39	Glycosyl_hydr19;	Glycosyl hydrolases family 39	Finn RD, Bateman A	anon	Prosite	Family	\N	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.63	0.70	-6.11	4	463	2012-10-03 05:44:19	2003-04-07 12:59:11	12	17	292	30	189	512	70	356.40	18	64.27	CHANGED	hthscsPclshsDutRshR.l..FWR...aC.....stus+hsLuhcpphphshhtshschGhE.lRhHhLL..DlhssRc.ssGpGLh..YNFTalDuhlDhLhE.tlhP....GF..hu.sSGphTsFc.K......+ph.cWp-LVphLAR+aIuRYGlscVpKWsFEsWNEPsh+DF.psuhppp.ahphYcssucul+tssssL+lGGP..........shChul.tahtshpNFhTtEs.V.lDaIShHppsuspuhhh.cp..tsltpscphhsEFt-s..lhp-EA.P.lsatlsp.......Yss.ss.hss.HpsP..hNuuhhhR..lLSpsssaLuh....FS.hThTshFp.sssp.......RpPhhsuhGLlALh...tl.t.s.+uhplLDu..tp...hlhtspHhsh...uspsshpsslllas....+shstpslPsp.hhlslP...shc.Valp..hlDp.pusPausW.+MGpPsaPotEQhcchRtsp-P.htcsspPhsssGcLTLchcLhhsSllLlclssR	...........................................................................................hh....................................................................................................................................................................................asa.t.lDthhDhh..h.t...thhP.....ua...................t.........s....s.....t.................t...................a.....................p....................................p.p..h.t.tW...t.pllpthsp+h.h...tR.Y...G..h.t....p....V.p.....p..W........aEl..WN.E.................Psh.....t............a...h...........................u........p...t.....p......a...h.p.hY...pt.ssc.sl+.t.s.....s.....P....t....h.p..l..G..GP................................................sh.s...h...s................t......a..h....phh..pa...h....ttp....t...h...........h.Da..loh.H.h.s.................................t......................................................................................................................................h.........................................................................................................hs...........................tt...........ss....h.........ht...................t..............h.....h.h....t.ht........................h....ss.......thhs.................th.t.s...h..htt.....tt.............t.t..................................t........h..hhh.t...............................................................................h.......................................................h......ss.....a.t..............s........t...h..h.....t...................................................................................................................................................................................................................................................................................	1	89	140	163
+2750	PF01915	Glyco_hydro_3_C	glycosyl_hydr14; 	Glycosyl hydrolase family 3 C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1151 (release 3.0)	Domain	This domain is involved in catalysis and may be involved in binding beta-glucan [1]. This domain is found associated with Pfam:PF00933.	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null --hand HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.56	0.70	-4.83	107	5906	2009-12-10 17:01:25	2003-04-07 12:59:11	17	121	2112	34	2239	5621	1277	251.70	26	33.08	CHANGED	hVLLKN-s.....tlLPLsppt..............+lAllGssAs......................................t....sh.t.......................................hsoslpulpptssssshhh...t..h............................................................................................................................................................................ssstthspAspsAppu....DssllhlG...........h...................................t....st.slpLs..tspppLlptl.ssss....tsslVVltsGsPlsh..hhp...............pssAllhuahPG........pcuGpAlA-lLaGc......sNPoG+LPhTaspsh.........sphPshh........................th...tt.sshhsau.cGL.hsh	................................................................................................................................................................................................................................................................hVLL.KN....cs.................thLP.Lptst............................plAVlG.s..As........................................................shh.h...su...ss.........ut..s.........st................................................hso..h.pu.lppt...h...s....p.s....s...h..h...h..h........h......h.............................................................................................................................................................................................................................................................................................sp.thhs..p...A..s..p...s.A.p.pu.........D..s..sll.slG..........tspt............................................................t..ts+...s.s..l...s.L..s.....t...s....Q..p...p..L..l.p.sl...t.sss............pss.........V...lV.l.h.sGpPls.l.t..h.tp................pssAlltsa.hsG...................p.p.u.G......pAl.A-l.La.G.c.................................hN.P...S......G......+...LPhoaPpsh..................................sphPsh.hs...............................................h.hpta...........st...t......sha.sFG...aGLSYo....................................................................................................................	0	741	1451	1968
+2751	PF02056	Glyco_hydro_4		Family 4 glycosyl hydrolase	Mian N, Bateman A	anon	IPR001088	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.86	0.71	-4.97	8	3002	2012-10-10 17:06:42	2003-04-07 12:59:11	11	5	1469	33	466	1859	496	179.70	40	41.67	CHANGED	KIshIGGGSohhschllu.lp+h-cLsspcltLhDlDt..cRL-tltphscphl-csussl+hptossh+-ALpDADFVhsplpVG....hhssRtlDE+IPh+aGlhu..t-TsGPGGIh+GLRoIPslh-Is+chE-hsPcAWhLNYoNPhuhlTcAhhRhhPthKslGlCchshGhpctlAchLsl	...............................................................KlshIGGGSoaTPcl...l.Ghlt...c......h......cc..Ls..l..p...clhLhDl-s...p+L..-hltt....l..sp...+.........h..l..c.......p........s.....u.....s..s.......h......c....l.p..t....T....h...D...p+cALp.D..ADFVhs.plR...V.....G...........ths...sRt...hDE+IPL+aGllG..QETsG..sG.G.lh+uL..RTIPslh-Isc-hcc.l.s.P.s.A.Whl.NaoNPuuhVTEAhh+..h..t..s.....t..K.hlGlC...sh.P.lGhtptlAchLt.l...............................	0	162	299	370
+2752	PF02449	Glyco_hydro_42		Beta-galactosidase	Mian N, Bateman A	anon	Pfam-B_2131 (release 5.4)	Family	This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyses the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.27	0.70	-5.34	28	1345	2012-10-03 05:44:19	2003-04-07 12:59:11	10	34	760	3	435	3006	388	314.10	25	47.10	CHANGED	DY.PEQWsc..-hap-Dh+hM+cAGlshVslGhFuWutlEPpEGpa-FuW.......LDcll-hLtctGlpllLuTP........TAusPtWlsccaPElL.l-tcGphptaGuRppaChoSPsY.RptstcIsctL.....AERYus+PullsWHlsNEYGs....tCYC-pCtpAF...............RpWLcp+Y.........ss.l-pLNcAWGTsFWSppYssa--I.sPp.ts.........phhsPuptLDapRFsoDplhsahct.ctchl+choPchPlTTNFMs........hpshDaachApclDhlSWDsYPs...........stcp......pssthuhtpDLhRul..tpGpPFhl.MEpsPS.sVNW.pshN.t+tPGhhcLhShpulAHGA-sVhaFpW..RpuptusEpaHuullsHsu.sso+sapEVsclGccLcpl	..................................................................................................................................................................Y.P-.ph...........t...phhtcDhthhp.ps.shshsp.lu.F..u....Wstl.E......P....p....c....G...p...a.....c.....F.s.a..............LD......c...h....l...c....h...h...t..........p..t..G..lp...l...h....L.......u....T...s......................o..u.s.............P.t.....Wh...h.......p........p.......a...P.........-...h...h.......h...s................p..........G.t.......h...............h....................h.........G.......s...R..........p....p........h........s....h....s.s..s.sa....+c...hs......t....pls.ptl......................A.c..+....Y.....s....p...c...P.....s...l.hhW.p............l......s.....NE..hus....................sas...p..t...s..t..ttF.....................................ppW..Lc..p+.Y.........ts....lc.tLNpA..W...s.......ss.....a.....W..u......p.......ph..psa...pp......l.........Pt.....hs.............................t.....s.h.......l...Da..pRF.spth.hphhp..phphl+....th.s.s......p.h.......lT....p.N.hh.......................sh-h.h..p.h.u..p.t..h..Dh....h..u..h..D..tY........................t...........................uh....tsh..hRsh............ttp.s..ahl.hE.......p.ps..u....t.h...t.........h........s............s.G........h.h.h.shtt.hAtGup.l....aapa..+p......u.Ephatuhl..st...s.hht-h.thst.ht..h...................................................................................................................................................................................................	2	150	293	365
+2753	PF04616	Glyco_hydro_43		Glycosyl hydrolases family 43	Bateman A, Finn RD	anon	Pfam-B_5336 (release 7.5)	Family	The glycosyl hydrolase family 43 contains members that are arabinanase.  Rabinanases hydrolyses the alpha-1,5-linked  L-arabinofuranoside backbone of plant cell wall arabinans.  The structure of arabinanase Arb43A from Cellvibrio japonicus reveals a five-bladed beta-propeller fold. A long V-shaped  groove, partially enclosed at one end, forms a single extended  substrate-binding surface across the face of the propeller [1].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.00	0.70	-5.32	37	5170	2012-10-02 00:26:57	2003-04-07 12:59:11	9	188	1022	90	1859	5327	430	265.80	18	57.35	CHANGED	hpNPllpGhhPDPolhRsscs...YYlssooFtha......PGl.la+S+DLssWp.lupslsptsphsh..tsss..........WAPslp....atsG+aalhao...............ps......sallsucssc...GPWo-shhl.........sstulDPolFhDss...GcpYLhhsths.t..............tIhhtchsssttphsups.phlhsus............shhhsEGP+la++sGa..YYLhsu....pGGTshs....ashsh...uRS+slhG.Paphpsssshlppt.....ssppslpssGHuullposcGc.aahsahstcs..............tshpshGRcThlp.lpWp.DGWP	......................................................................................................h...s...DPt...lh...t...h.........sst......a..Y..h.h....s......o....s.............................................t..h..........lh..p..S...p..D..L.........h......s..W...p........h..s.................s...h............s.........h............t............s.....t............t....h......t.tt.t............................W.....A...P.p...l.h.......................h..t..s..G.....c.....a..a.laas.....................t....t.ttt...................................hh.l.h.....p...u.....s...s..sp..........G.s.a...p...p....hth.......................................sttslD......s...sla.h.......D.c.....s........G.......p.h..Y....h.h......a.u.s.......t...................................t.l...h.....h....s..c..l......s.....s..s...h....h...p....h.....t...s..th..........t...h.hhtst........................................h.h...E...u.P....t..l....h...+......p...s......G..h.......Y.Y..l..hh.u.....................ts.s.s.t.s...........athsh...............................spu..p..s......h.G......Pa...........p..............t....t......hh..................................t.tt..h.........s.s......u.H.s.s..h..h...p...............p...u.....p..........h.h.h.ahsht........................................t...R...h.h..lt....h.ap...ss...................................................................................................................................	0	663	1303	1655
+2754	PF02015	Glyco_hydro_45		Glycosyl hydrolase family 45	Bateman A	anon	SwissProt	Domain	\N	20.30	20.30	21.70	20.80	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.30	0.71	-4.25	6	228	2012-10-01 21:39:58	2003-04-07 12:59:11	11	13	86	7	88	232	2	179.70	43	69.24	CHANGED	sGpoTRYWDCCKPSCuWsu..KuPs.tPV.oCstsssslss....ssspSGCp.GGuuYhCosppPa..sVsssLAaGFAAsohsGusEsshCCACYtLTFTs....GsltGK+hlVQuTNTGGDLGsspFDhshPGGGVGIFs.GCssQaG...uhhGsQYGGlpStpECsphP-sLpsGCcWRF.-WhcNsssP.hSFcpVpCPupllucSGCp	.......................................GhTTRYWDCCKsSCuWss..............K...A.ss....s.p...P...lpoCsts.s.ps.hss.............ssspSGCs...G...GsuYhCssppPW......uVN..ss....hu.YGFA...Ass...h.....s.....G.s...EsshCCsCapLTFTu..................uslsGKcMlVQsTNTGuD..L.....G.......s....N.....p.FDlthPGGG.VGhas.GCs..p...Q.a.u..s.s.st...aGpp..YG.Gl............s.o.........tspCsp......hP.....t..tLpsGCpaRF..sahtss....sNPshsFppVpCPtplsshosC.................................................................	1	41	60	80
+2755	PF01374	Glyco_hydro_46	Glycosyl_hydr23; 	Glycosyl hydrolase family 46	Bateman A	anon	SCOP	Domain	This family are chitosanase enzymes.	20.80	20.80	25.50	24.80	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.33	0.70	-4.79	7	127	2012-10-03 00:09:25	2003-04-07 12:59:11	13	7	97	4	42	129	4	207.80	39	69.76	CHANGED	hpLluhsENuohpWhppYsYsEclcDGRGYTsGIhGhsoG.TGDhL.llt.hpchsPsshLsKalPuh++stt.....hcppuslhshhsp-p.WpotspDh.hc.A.scstDcoaas.sAhppscssh....poALspushhDsslpHGsssss-SFtullKRstp+sp.......DEtpahpsFhssRhtsLhsstsc.spscssp..sRshhhsslhcpsNhsLK	......................................................................................hpLlSpsENSolcWctQ......YuYlEDls..DGRGY.TsGIhGFsoG....TGDhLplV.EhYspt...pP.sN.s.LupYLPALRclsu.......s-sp....sulssh.......hsts.....W.p..psA.p....D.tFctAQcctpD+lYas.PAhppucpsG....hssLuphsaYDshl.HGs..u..ss....s....s.....o..Ftulpc+uhpcAp..P.t........GsDEpsaLsuFLDsRh.sht...p..c..ts.cp.-sochcp..AphshlpphshphpssL..................................	0	18	32	40
+2756	PF02011	Glyco_hydro_48		Glycosyl hydrolase family 48	Bateman A	anon	SwissProt	Family	Members of this family are endoglucanase EC:3.2.1.4 and exoglucanase EC:3.2.1.91 enzymes that cleave cellulose or related substrate.	25.00	25.00	40.60	40.50	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	619	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.33	0.70	-13.25	0.70	-6.39	7	213	2012-10-03 02:33:51	2003-04-07 12:59:11	10	23	126	21	57	214	0	485.10	49	70.58	CHANGED	YtpRFhphYsKI+DPuNGYFSsc.GIPYHuVETLhVEAPDYGH.TTSEAaSYYlWLEAhYG+lTGDaStFppAW-shEcYhIPsppDQPst.MSsYsPNKPATYAsEapcPShYPS.Lchs.ssVGpDPltsELhSsYGos.lYGMHWLhDVDNWYGFGtpsst.......sopsoaINTFQRGsQESsWETlPQPsh-EaKaGGpNGFLDLFTtDs.sYAKQaKYTNAPDADARAlQAsYWAs.WAKEQGK..slSuhVuKAuKMGDYLRYuhFDKYF+KlG..s..pspAu.TGYDuAHYLLSWYYAWGGulsu..sWuW+IGsSHsHFGYQNPhAAWsLusDu-hKPKSsNGtsDWApSLcRQlEFYpWLQSAEGuIAGGATNSWsGRYpphPAGTsTFYGMuYs.pPVYtDPGSNpWFGhQAWSMQRVAEYYYtoGDspAKpLLDKWVcWlhuplplssDG.TFpIPSsLcWoGQPDTW..suoYTGNsNLHVcVssYGsDLGlAuSLANALhYYAstotc......ppA+shAKc....LLDthWt..YpDs.KGlussEsRuDY+RF.-p......pVYlPuGWoGpMPNGDsIcsGlpFlDIRSKY+pDPsWsplpsAhpsGpsPshpYHRFWAQsDlAlA.GsYuhLF	..............................tcFht.atpl...ps....t....sGYas..p........G......lPYH..SlETLhl.EAPDaGH.TTSEAaSYhlWLEAhYG+lTG....D........W.o.....h.....hpsAWcshEpYhIP.....s.p.....p-....QPs...stY....ss.spPATYAsEh.ppPspYPu....lphs.sssGpDPltsELtSsYGost....hYtMHWLhDVDNhYGaGpt.st.......sotsoaINTaQRG.pESsWETlPpPoh-pF+aG....t.....N..GaLsLFst.-s...s..........u+QW+YTsAsDADARAlQAsYWA..WApppGp....plushhsKAuKMGDaLRYshaDKYFpplG...sts.p..s.s.su.sGh-SsHYLhuWYhuWGGuhss.....sWuW+IGsSHsH.GYQNPhAAaALus......s.shtP..KSssutpDWtpSLcRQlEhYpWLQSuEGAIAGGuTNSWpGpYtp.Pu..G..s..s..TFYGMhYs.tPVYtDPsSNpWFGhQsWshpRlhphY.....................p..G............s............tt......s..........t...........tlhc+Wh.Whht.h.ht....t.s...pa....hPupLpW.......sGt...P........................sss..lpsps.s.s.p.DlGhhuuhspsL.aauststt..........................................ttutthAptLLDthat...pst.hGlss.E...ttsY.Ra.p........tlYlP.tsas.Gp.spGs.l...........psu..................pF.slRshhppDs.a..l.thht......s......u..................P......hpaHRFWtps-hAhA.u.ht.h............................	0	22	43	49
+2757	PF03718	Glyco_hydro_49		Glycosyl hydrolase family 49	Finn RD	anon	Pfam-B_8840	Family	Family of dextranase (EC 3.2.1.11) and isopullulanase (EC 3.2.1.57). Dextranase hydrolyses alpha-1,6-glycosidic bonds in dextran polymers.	21.30	21.30	21.90	22.60	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.97	0.70	-6.44	4	30	2012-10-02 14:50:22	2003-04-07 12:59:11	8	4	25	8	8	54	0	496.90	33	80.09	CHANGED	sus.psAhpstpsssTsssupLpTWWHssGEhNspTPsQsGNVRpSuhYsVQVupAsssps.hYDSFsYhSIPRsGpG+I............s.o..DGhpaosuhsLoMuWSSFEYS+DVhVclphpsGpolsSsspVsIRPoShsFthphsDssoVhI+VPYSssGYRFSVEF-spLaThhsD..Gst......suGs.psltsEPcNuhhIFApPhL.ut.tpphlPp.sSsshphPpPG.VpNLsosocpllYFpPGsYaMsscp..........HhsLsuNVpWVYLAPGAYVKGAhcFh.sTpupaKsTG+GVLSGEQYVYpADsssuYh.hSsAspscsosl+MhpassusutQp.hslpGlTlutPPapShsh.GNp....hphpV-sYKQVGuaYaQTDGhElY.GohhpssFaHsNDDsLKhYaSsVTlcNsVIWKscNuPVIQaGWTPRNI-NVslsNssVIHsRhhhp-shhNosIhsuSsaY....tshuSs.oouDospTlpNhphpNhssEGhosshhRIhsLpNh-NIpIKNlsIsuasGLp...hsop.Sal.taoshsstK........sspGlslENaTVGGppI..TssN.psspLGRls.hDsp.WssWphh	...........................................................................................................................................s.................hsssthpTWWHssu.hs.t.tshtsspVRpSphYpVpVt.As...t.pp.hacSFsY.SIPRsGpG+................s.o.tDGh.phpsphshsMuWopFpYspDl.lcl..psGpslsssspVsIRPsshsathp.ssstslh.I+VPhp.sGh+FSVEFpsplhohhss...Gpp....h.spGs..hlt.EPpNuhhIFApPhl.st....hlPp.pss...........s.s.hhpsG.lsshs.socsllYFtPGlYahs..pct..........+hpLssNspaVYlAPG.AYVKGAh...cah..tsppsapssG+GVLSGEpYVY..pAssspsY...h.........Aspscppsl+Mhhapsssu.sQp.hphtGsTlssPPapohslhu......spt........hpsplssYKQVGuaaaQTDGhplY.psS..h..l..+..csFaHsNDDsl.....KhY......a....S...s.........sslcsssIWKscNsP.l.I...QhG.....Ws...s..Rs.....Is.sVslcslslIHs....RhhhspshhsosIhsuSsaa.......uss.hpsDsppph.shphpNhssEGhss.sh..h+lhsLpN..hcthhlcNhth....s.sht......hsht.sh..h.thps...............shGl.lpNaolGsppl..shpNhtttphGphs.hcst.hspWph.t...............................................................................................	1	3	4	8
+2758	PF03512	Glyco_hydro_52		Glycosyl hydrolase family 52	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	276.40	276.00	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.30	0.70	-5.88	4	35	2010-01-08 16:07:30	2003-04-07 12:59:11	8	1	33	0	14	36	16	418.20	50	59.32	CHANGED	FTLGaPGpuGGLDLELG+PPcQNVYIGLpS.c-ttpYcsLPFatsu.pDEusRYDlEpsDss.......pQcPp.llhPFs+-EIhR-FsuuTDTWpAGDLTFpIYSPVcuVPDPpsAsEEEL+hALVPAVLsEhTIDNTcGppsR+AFFGapGsDPYSuMR+I-Dsss.plsGVGQGRlTuIsSsDculpsAlaFohEDlLspthcENhsFGLGpsuALlhDVPAGEK+TYpFAVCFYRGGlVTsGhDsoYaYTRaFpsIEEVGEYALtQFstlttputcu-pLlssutLS-DQpFMhAHAIRSYYGsTQLLEH-G+PLWVVNEGEYRMMNTFDLTVDQLFFELKhNPWTVKN.LDLaVcRYSYcDcVRFPG--TEYPGGISFTHDMGVANoFSRPsYSSYELaGIDsCFSHMTHEQLVNWlLCAoVYl	..FTLGahGpsGGLsLELu+PscpNVYIGhco.cpsuhYchLPFacss.p-Euc.RYshEps-ss........p+ss.hlhsFucccIpREapsATDTWpAGDLT..FplhSPhcsVPDPts..As--EL+hALsPAVhsElTlDNTpGopsR+uFFGapGsDPYouhRhl.........s-.........ss....s.....pLpGlGQGRphuI.s.o.p.-.csVcsuhtFuhEclLssphpcNh.sFGLGpsGALlh-VPAGEK+TYpFAlCFYRuGhVTsGh-sSYYYTRaFcsIE-VupYAL-phsthtstutptschlc.pu.tLS-DQ+FMlAHAI+SYYGSTQL.L..-.....c.........-Gc.PlWVVNEGEYRMMNTFDLTVDQLFaEL+hNPWTV+NsLDhaVcRYSYcDpV+FPG-.-pp......YPGGISFTHDMGVANsFSRPsYSuYELsGls.uCFSaMTHEQLVNWlLCAsVYl.	0	4	8	10
+2759	PF01630	Glyco_hydro_56		Hyaluronidase	Bateman A	anon	Pfam-B_1150 (release 4.1)	Domain	\N	18.70	18.70	19.80	19.40	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.04	0.70	-5.80	11	533	2012-10-03 05:44:19	2003-04-07 12:59:11	13	6	152	6	235	478	2	274.00	38	74.85	CHANGED	hRuP.llsspsFlhsWNsPTphChtchshslDlSh.FullusPpcshpGQslTIFYs-cLGhYPalssps....pthpGGlPQpusLppHLs+spp-IpphlPs.DhsGLAVIDWEcWRPpWtpNWpsKDlY+ppSl-LVQspHPphshscsptcApppFEcAA+tFMp-TL+LGKhLRPptLWGaYhFPDCYN.hcapsss..YsGpC.ssphpRNDpLuWLWppSoALaPSlYLpppLpusp+s.t.h.VRtRVpEAlRVu+lscsspslPVhsYsR.lFpDpsspaLoc-DLlpTlGE.sALGuuGlllWGohuhspotpsC.tL+pYhpopLsPYllNVThAAp	....................................h.....h.tpPFhhhWNsPop.Ch..+ath.l....s........l.ph..Fslhssstpp.h.t.G.p........slTIFYtspLGhYPahs.ps.............hshpGGlPQpss.LptH.Lpphtpcltt.....hlss.p.tGLuVIDW.............Et....WRPhWtpN.Wt.s.KclY+ptS......htllpp..p.....psp....h.s.......p..p.ltt.AptpFEtuA+taM.pTLpLupthRPptLWGaYhaPcCa..N.ashh..p..s..s....YoG..pCsshthtcN.-pL.tWLWtpSsAL.aPSlYl..tltss...ps.....Vp.RlpEAhRluthh.p.t............hPVhsY..s+..h.....h...p..t..............s..p.......h....Lop...tDLhpTlGEosAhG..uuGlllWGs..p..sp...o.....p..pC.tlppYlpp.Ls.alhNVo.us........................	2	43	64	130
+2760	PF03065	Glyco_hydro_57		Glycosyl hydrolase family 57	Bateman A, Moxon SJ	anon	Pfam-B_2506 (release 6.4)	Family	This family includes alpha-amylase (EC:3.2.1.1), 4--glucanotransferase (EC:2.4.1.-) and amylopullulanase enzymes.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.98	0.70	-5.54	22	1145	2012-10-03 16:37:10	2003-04-07 12:59:11	10	25	737	10	560	1481	541	339.30	17	56.79	CHANGED	sFhhHpp..hh.p................................uspsYl..........shhphlhch.p........h+hshsloGshlEQlpchtsph...............................................................................................................................................................lpha+p...LhcsGp..lEllsssaaHslhsllsc.....................p-hhpQlchtcchhcchFG...hcPpuhassEhsass................clhchltchGhchlhs-stth..............hhsspsst.hah.......tspt...lslhhRshpLScpIuFpa.......usccah.................pa.h....hh.hhstspspllhlhhDhEsa.....staphtppshh-hhhth..phppp.................shlphhtsp..Ehhpchtscshlhhs.tt.....................................hsWh...........ctshstWlus.tppthhptl	...............................................................................................................................................................................................................................................................................................................h.hH.p...hh......................................t.........................ht.psYh................shhthh.ph.p..........hph.shshosslhp.lpp.h.t............................................................................................................................................................................................................................................................................................................................................................ls.h.h+p.........L.c....p..Gp...lElls...ssasH.s.....l.h..P.Lhsp.......................csh.ptpl.....phuhpt..h..cc..h..F..G....ppP.c.G.hWhs...E.tu.ass........................................................sl..hphl.sp.t.G...h..c..a.h..h...s-stth............................................hhs.ht...s..s.p...ha.t..................sspt............................ltlh.hRDhplS.p.plh..ph..........................shccah..................................................................ph.h..............hh..t..........t............s..th.h.....hh..hchc..th...........tht.....tp.hht...hh.....t.....t...ptt.....................................t.....l..t..h..hp.p.....ch.h..p.....t.h......................h.................................................................pWh.................................................h..........................................................................................................................................................................................................	1	229	411	492
+2761	PF02057	Glyco_hydro_59		Glycosyl hydrolase family 59	Mian N, Bateman A	anon	IPR001286	Family	\N	27.00	27.00	27.20	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	669	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-13.24	0.70	-6.46	3	168	2012-10-03 05:44:19	2003-04-07 12:59:11	10	10	93	2	88	169	18	493.00	37	83.35	CHANGED	MTAAAGSAGRAAVPLLLCALLVPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNIILMGLPWSFPGWLGKGFsWPYVNLQLTAYYVVTWIVGAKHYHDLDIDYIGIWNERSFDANYIKlLRKMLNYQGLQRVKIIASDNLWEPISASMLLDuELaKVVDVIGAHYPGTHTVKDAKLTGKKLWSSEDFSTLNSDVGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPIWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHStCIRPFLPYFNVS+QFATFVLKGSFSEIPELQVWYTKLGKPSERaLFKQLDSLWLLDSSGSFTLELcEDEIFTLTTLTTGRKGSYPLPPKScPFPosYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHRFTLRQVLNQRPITWAADASNTISIIGDY+WTNLTV+CDVYIETP-oGGVFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVDVTAKKWYTLTLsIKG+FASGMLNGKoLWKNIPVsFPKNGWAAIGTHSFEFAQFDNF+VEATR	......................................................................................FcGhGslS.ususs.SRLLhsY........c..s.......hs...pILcaLF.tss.aGAulph...LKVEhG..u..........D....spoo.....s.....Go....EPSp......+h.t..-.t.......N.....h...R..GYp...ahLht-AKphNPsIplhsLsWuhPGW..l...s......p.....u...............s.........h................p.....hss...........Y.h.h.pW....l..............uu.tphasLslDYl.u..h.h.....NE+.s..a...s.h.p......a.l.K............h....LR.p.hL....................s..........tp......G..........hppl+IlAuD......sh...a...t...s...lu..ts.hh.DspLhpsl.sllGs..H..Y.....s.....s....s...........ss....t........p........u........s...t...KplW.sSE.....shS.......s..h.......s...........p......h......G.u..........us........h.u......Rh........L...N...ps......Yl.su.....hT....uhIsWs...........lluuaY.tlsaspp.uLhs..AppPWSGtY.lps.slWl...AHhT.QFspsGW.hY.L...p...s....s..Gth....pt...........s.GSa..Vu.Lss.s.h.s.......s.h.ohllE.....Th.s.....tp.t.s...h...........t...s..p.hp..h.l...psth..t.t......tlpVW.op...h...s.t....s..p.t........a.phtsh.......s.tG..taolp..lt.splhTlTTh..sst.t+..u.sh.s..ss.....st....hs...............Yp-s..Fs...t.........hs...t..........s..h.s.D.tGsFEhh.s........tt...thhsh+Qh...sptslsWts.......s..hshlGs.pW.s.htlp.Dhhh-............t...h.l.hths..ts......tt..........sh.....h.h.l...ts.Gtat..l...........t.t..........................h..t........h.....t..Whpltl..h.t.....s.......st..h......................G.hshhs..h...spaDsh.l....t......................................................................................................................................................................................................................................	0	35	48	63
+2762	PF01341	Glyco_hydro_6	Glycosyl_hydr21; 	Glycosyl hydrolases family 6	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	17.70	17.70	17.70	17.70	17.20	16.60	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.16	0.70	-4.98	74	628	2010-01-08 14:25:27	2003-04-07 12:59:11	12	33	332	44	282	614	35	289.60	31	63.55	CHANGED	sNPhas.uphtstst..t.....ushssttpplA.phPouhWl.sphstsss...........ltstLsshhupttsusp...sshhVlYslPsRDCsAhASsG....ussuhspY+s.YIDsIsstl...................tassh+sllllEPDoLuNhlTs......ssspC....t.ss..pstahpslsYA.lppLtshs.NVthYlD........AGHuuWLG..ss...uAplhuphhpsAGss...plRGhuoNVuNYssh.............................hDEhsYtp.................slsstLsstGh.ssc...................................................FllDTuRNGhss.........................p.thGsWC..NssGs.GhGtpPosss...usshlDAalWlKssGESDGs.......ssssustaDt	............................................t.h....s...........t.....ss.ssthppl.u.shPsuhWl..sph...s.ss...........ltstlsshh.ststssst...hshlVlYslPsRDC...u.ht.S.s.G..........ussshspY+s..aIDslAshl.......................us..hpsllll.....EPDuLsph..................hspC...........t.ss...pst..hhp.tlpYA.lppL.t.shs.sstsYlDAGH.uuWL..............uAph.huphlpssGss........ps+GFusNVuNapsh.........................................-EhsYsp..................s.lsshl.st.th..ssp..........................................................allDTSR.NGhus.............................t..usW..C.........NssGtulGt.Posss....ssshlDAalWlKsPGESDGss....ssttu.h...t.........................................................................	1	93	195	260
+2763	PF03443	Glyco_hydro_61		Glycosyl hydrolase family 61	Bateman A, Eberhardt R	anon	CAZY	Family	Although weak endoglucanase activity has been demonstrated in several members of this family [1-3], they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases [4].	27.00	27.00	27.50	27.70	26.30	25.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.53	0.70	-4.52	55	827	2010-01-08 16:05:35	2003-04-07 12:59:11	9	12	88	14	728	841	1	202.70	30	69.52	CHANGED	HuhVsslhl..sGspYsuapssth.hts.........s.st..ssssG.l..sshsSsDIh..................Cpp.......su..ssussps.sVsAGsplshp.Ws...............aspSH...+GPl......lsYLApC..sss.Csoss..pouhpaFKIspsG...hssuops..........Wus..........DpLI.sssssaslpIPsslusGpYlLRHElIALHuAu........sts........GAQ.YPpChplpVTGuGoss............Pu.G...VshsuhYpsTDPGIhh..sIYps.s......s.Ysl	........................................................................Hhhhtthhl..sG....tth.......................................ssusl........ps...h.s.os-lt......................Cst.................su.....ss..u..s...s..p.s.....sVtAG.spl.shphs...................................hs...s....H....G.Pl...................hsYhucs.....sss...ssshs....ssuhtWFKItptG..............hss..ss.t.................Wu.s....................t..h.....t.....s.....s..s...p...hshp........IPpslssGpY...LlR.tEh...IA.......LHsAt........p....s..........GAQaY...pCsQlpV.o.G.u.Gsss.............Pu...s................Vp.h.P.G........hYp.s.sD.P.G.lh..h......slYts.......sY.......................	0	249	456	651
+2764	PF03664	Glyco_hydro_62		Glycosyl hydrolase family 62 	Finn RD	anon	CAZY 	Family	Family of alpha -L-arabinofuranosidase (EC 3.2.1.55).  This enzyme hydrolysed aryl alpha-L-arabinofuranosides and  cleaves arabinosyl side chains from arabinoxylan and arabinan. 	20.20	20.20	20.90	20.40	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.99	0.70	-5.27	5	187	2012-10-02 00:26:57	2003-04-07 12:59:11	8	20	99	0	116	198	2	263.70	55	59.08	CHANGED	CALPSoY+WTSTGALApPKu.GWAuLKDFTsVsaNGKHIVYASsaDTuosYGSMuFGPFoDWS-MASASQTAMSto....AVAPTLFYFAPKNIWVLAYQWGuooFSYRTSSDPTNPNGWSAsQsLFoGpI..SGSuTGAIDQTVIGDDTNMYLFFAGDNGKIYRSSMPIuNFPGSFGopYolIMSDoTsN....LFEAVQVYTVDG...QN+YLMIVEAhGSuG.RYFRSFTAoSLsGsWTPQAATESNPFAGKANSGATWTsDISHGDLVRNNPDQTMTVDPCN	...............CsLPSoY+WoS.T..GsLAp..PKs....G..W..suLKDFTsVsYNGpaLVYAost....s....u.u...s...aG.SMsFusFosWSphuSAsQs.....thspu.......sVAPoLFYFAPKslWlLsYQ.WG.s.s.sFuY+TSoDPoNPNGWSusQsLF.o...G...o...I.....ssu..ssG...s...ID.sl.IuDspNMYLFFAG..DN..G.+IYRuoMPluNFPGuF.Gossssl.hSD.o..p.sN....LFEAspV...Y+lpG...ps..p..YLMIVEAIG..u..sG.....RYFRSF.TAoSLsGsWTPpA..uoE..o.NPFAG.....KAN....S....G.....A....o.WTsDISHG-LlRs.ssDQThTlDPCN...............................................................................	0	30	74	107
+2765	PF03633	Glyco_hydro_65C	Glyco_hydro_65c; 	Glycosyl hydrolase family 65, C-terminal domain 	Finn RD	anon	Pfam-B_3470 (release 7.0)	Family	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP)  is a dimeric enzyme that catalyses the conversion of maltose and  inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  The C-terminal domain forms a two layered jelly roll motif.  This domain is situated at the base of the catalytic domain, however its function remains unknown [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.48	0.72	-3.88	18	1485	2010-01-08 16:08:30	2003-04-07 12:59:11	10	16	1123	2	318	1157	33	52.00	27	6.46	CHANGED	PhLPctast.luF+.lhaRGph.lplplsppplplplhpGp..sLslclhGcclsLcs	......PtLPcpWpp..luFp.lha+Gph.LpVpls..p..p.p..lslph...pu............sl.slpl.Gp.hpl..s.....................	0	86	198	275
+2766	PF03632	Glyco_hydro_65m		Glycosyl hydrolase family 65 central catalytic domain	Finn RD	anon	Pfam-B_3470 (release 7.0)	Family	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. The central domain is the catalytic domain, which binds a phosphate ion that is proximal the the highly conserved Glu.  The arrangement of the phosphate and the glutamate is thought to cause nucleophilic attack on the anomeric carbon atom [1].  The catalytic domain also forms the majority of the dimerisation interface.	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.27	0.70	-5.78	16	1977	2012-10-03 02:33:51	2003-04-07 12:59:11	10	29	1435	2	510	1594	109	362.80	34	46.01	CHANGED	Rhsl......FaLhpshss.......p-....scLs...........lus+GLoG-u.....YtGtsFWDTEhaslPhhl.hstPclA+sLLpYRhppLsuA+..........csA+phGhp.GAhaPWpoup...GpEso..........s.cht..ss.ppphHlsusIAaA.lhpYhpsTG..DppahpcpGh-lll-sA+FWsu+schspp.stapIcsVsGPDEYc........sslssNsYTNhhAtasLphAhchhcphspt..........htlppp-hcpWc-l...ucphalPhccp.GV.......h.Qa-Gahcht.hshtt...h..t.h...h..chthspl.ptphlKQADllhhhYh............htttastcphtpN....h-aYts+Ts+-S.oLSsslaullAAchsch...spAh-aa.pcusc.................lDl.cs.sss.Tp-Gl.HlsuhuGshpsllpGFuGh...+hc..........sspL	.......................................................RaslapLhtshss........p-.......tchs.............Iu..sKGL....T....GEu.......YtGHsFWDT.E.ha.hlPhal.hsp..P.p.lA+.s.LLpY..RappL.stA.p................cpA.......p.......p...............G.......h..........p..G..AhaPWpoh..p....G...p...Eso.............s.pht...hu..ttphHlsusIAaA.lhp.Yh.psTG..D....psal.t.c.p.....G.h.c.lLlEsA+FWss....t.s.p....h....s.....p....t..............s..c..apI.cs.VhGPDEYp...........ssVsNN.s.YTNhhAtasl...ph...Ah....phhpp..hspp.................thth.s..p.t......-htp..W.pch.........scphhlP.h...s......p......p........Gl........hsQpDuFhsht..h.s.hsp.....h.spph......l..c.h.ph..tpl.chphlKQADVlhhhYh..............hs.cpF..ot..p.p.ttpN....hcaYEs.hT..s..H..-..S...SLShslaullAA.cl.Gh.......pp.Ahpha.pcusp......................lDL....s....s..s.....p.s.....sp.....-.....G..l..H.h.....suhuGsWhulltGFuGh...csp.pst.......................................	0	155	305	432
+2767	PF03636	Glyco_hydro_65N	Glyco_hydro_65n; 	Glycosyl hydrolase family 65, N-terminal domain 	Finn RD	anon	Pfam-B_3470 (release 7.0)	Family	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP)  is a dimeric enzyme that catalyses the conversion of maltose and  inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  This domain is believed to be essential for catalytic activity [1] although its precise function remains unknown.	18.80	18.80	18.80	18.90	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.62	0.70	-5.07	14	1768	2012-10-02 23:57:29	2003-04-07 12:59:11	10	18	1343	2	416	1391	80	251.00	25	31.06	CHANGED	plppsphshpp.p+h.pESlhulGNGYhGhR........Gs.....h-Eshss...............ph.GoY..luGla............phsp..........lu....Ghsp.hpcllN.hsNahtlcl.hlsGcs.hDlst...sclpsappsLDh+pGlLpRphphp..s.ps.lclpscRFlShspppLuulchplp......sl-sps.clpltshlDusVsNcs...p...thhphhsp........chpsss.shlhscT..hsss......htsshsspphs.tsspt.h...sphp.sppcphlspphpsplp.spphplp.KhVslso.ScDh	...................................................l.ppphs.cp...hph..tESLhulGNGYlGhR.................Gs......hEEs.h.s..t............................................................................ph.tGsY...luG...la...................p..t.tp...................hu.........Gh..sc.....hpc.llN...sPshhshcl...tl....s.......s...-.......hsLsp........splpsapppLDh+p..............GhLpRphhaps.s...s.....G............pt...lplsscRFlShsphplsslc.hplp.................slss...s.s....plplpotl.......D...u..s.pNps.......................................hhptlsp...................p.s...t.spp....hhlh..hpT....ppss..............h..s.lsh.....uss.p..........h......t...s.........s.p....................t..............h.p.t.p....p......p.tltpp....hp.spl.p.tGps.h.slp.KhVhlts..Sc-................................................................................................	2	125	264	361
+2768	PF02435	Glyco_hydro_68		Levansucrase/Invertase	Mian N, Bateman A	anon	Pfam-B_2011 (release 5.4)	Family	This Pfam family consists of the glycosyl hydrolase 68 family, including several bacterial levansucrase enzymes, and invertase from zymomonas.	19.90	19.90	19.90	21.30	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.46	0.70	-5.77	11	358	2012-10-02 00:26:57	2003-04-07 12:59:11	11	10	223	29	68	411	121	335.70	36	80.16	CHANGED	hps.s....sophTRADhLKlspp.p.ss...........Th.sIsushsl.ss.....-l.VWDoWPLp-hc.GsVssasGapllFuLsuD.p.....................Rpscs+IthaYp+sGc.........sWhhuG+lht-uss.........spopEWSGoshlss..cGslcLFYTs..h........sssu..pulsstshshhhsD-psVplcGhpps+sLF.p.uDGhhYQshtQs.h.................asFRDPHsh.D..pcG+pYhlFEuNsusEc.........spsshGts-hhsls..ssh.ss.....ssApassGuIGIsphpDspt..o.hclhsPLlTussVsDpsERPpVlh.sGKaYLFThS+tsphu........DGlsGsDsVhhhhusstLpGPYcPlN.uSGLVLsss...............sp.s..hpTYSHashPs...G.ssshhshhsspst...hctsuThAPoltlplpGscohlscshs.......G.IP	.................................................................hohtshhpl.t....ps............s....ls.sh.s.h.sp.............pl.lWDohPLpphc...up.hsh....pG..apllhsLsus.p.....................ppscsplhhhYp+.hG.p.............sWh...uGp..lh.pssp......................................pspEWuGoshl............p..tsplpLaYTs.........................p.....thhst...hsh.h.sss.tl....hpshpp.+.lh.p.sD.....GhhYQs...tQ............................................as..hRDP..h.D.....sG.phYhlF.E..uNsus.p...............s.t.hsts.p.h.h.....th.p.....................ttA.htsuslGlhhhps.............p.hchhsPLloussVsDphERPphhh.s....GKaYLFT.S+t.phs........suls.u.s-sh..hhhhspt.lhusYhPhN.soGLVLsss.................t.s..htoYSahsh..Pt.......................u....s.shhs..............h.......s..t...............................................phtuT.APohhl.lpus.p.o.h............G.h........................................................	0	18	35	50
+2769	PF00840	Glyco_hydro_7	glycosyl_hydr13; 	Glycosyl hydrolase family 7	Bateman A	anon	Pfam-B_1478 (release 2.1)	Domain	\N	19.60	19.60	37.50	19.70	17.30	19.10	hmmbuild  -o /dev/null HMM SEED	433	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.81	0.70	-6.11	18	5196	2012-10-02 19:29:29	2003-04-07 12:59:11	15	7	239	68	226	5216	4	183.50	64	97.72	CHANGED	QsGT.TsEsHPpLTWp+CTsuGs..CsshsupVVlDANWRWhHpssGtT...NCYoGNpWsoolCPDspTCApNCsLDGADY..suTYGlTTSGsoLoLpFVTpss...tpNlGSRlYLMssDoc.YpMFpLLspEFTFDVDlSpLPCGLNGALYFssMDADGGhu+assN+AGAKYGTGYCDuQCPRDlKFINGpANlEGW.sSssssNsGhGshGoCCsEMDIWEANShusAaTPHPCsssu.QptCsGssCG.s.s....RauGhCDsDGCDFNsYRhGspsFYGsG..hTVDTo+pFTVVTQFlssss...GsLsEI+RaYVQNGpVIpNussslsGlsssssITcsFCsupKssFG-ps.Fsc+GGLspMGcALupGMVLVMSlWDDauuNMLWLDSsYPsssss.tPGstRGoCssTSGsPupVEussPsupVsFSNIKFGsIG.STa	.................................................................................................................................................Y.T.G..N.s.Ws.sTlC...P..D..s..t..o.CA.pNCA.lD.GA...D...Y....sGT.YGI..T.T........S..G.N.u.Lo.L+FVT......pup......uoNl..GSRl..YLM..p..s....D.op...Yp....MFpL.l.N.p......EFTF...DVDVSpLPCGLNG..AL.YFV.pM...DuDGGhuK...a.s.sN......KA..GAKY..G...T......G...YCDuQ........CP+DlKFI....N....G......p..........A..N..lcGWss.Ss.s.DsNAGsGpaGoC.CsEMDIW..........................................................................................................................................................................................................................................................................................................................................................................................	0	86	145	203
+2770	PF02324	Glyco_hydro_70	Gluco_S_transf; 	Glycosyl hydrolase family 70	Bashton M, Bateman A	anon	Pfam-B_965 (release 5.2)	Family	Members of this family belong to glycosyl hydrolase family 70 [1] Glucosyltransferases or sucrose 6-glycosyl transferases (GTF-S) catalyse the transfer of D-glucopyramnosyl units from sucrose  onto acceptor molecules [2], EC:2.4.1.5.  This family roughly corresponds to the N-terminal catalytic domain of the enzyme. Members of this family also contain the Putative cell wall binding domain Pfam:PF01473, which corresponds with the C-terminal glucan-binding domain.	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	809	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.63	0.70	-13.54	0.70	-6.77	12	260	2012-10-03 05:44:19	2003-04-07 12:59:11	11	22	109	32	37	910	3	705.80	50	54.62	CHANGED	LLMsWWPDKpTQlsYLNYMsptshhs..ss..aospssQtpLstAApplQtpIEpKIupptsTpWLRpshssFVKTQPpWN.pSEs....stcDHLQsGALLasN.SshTsaANScYRLLNRTPTsQTGp.t.+hpt...s....GGaEhLLANDlDNSNPVVQAEQLNWLHYlMNaGoIsusDs-..ANFDGlRVDAVDNVsADLLQIAuDYhKAtYGVccs-tsAhpHLSILEAWScNDs....Ys+DpssspLsMDNhhRLuLlaoLs+.................s.shRushpshIs.............suLssRos-sppspshsNYsFlRAHDSEVQolIAcII+cpINPsssGhoh..ThD-lKpAFcIYNpDhtpuDKKYTpaNlPsAYAlhLoNKDolsRVYYGDhYTDDGQYMApKSPYYDAI-sLLKARIKYVAGGQsMps.h..sss.....s........lLTSVRYGKGA.pAoDs.GstpTRspGhuVlsuNpPsL+LssscplslNMGAAHKNQsYRPLLLoTpDGlssYhsDu-A..tthV+hTDspGpLsFsAs-ItGhpNsQVSGYLAVWVPVGAu-sQDsRssuSspsss-G.placSsAALDSQVIYEGFSNFQsFss..psspYTNtlIApNssLFKsWGlTSFEhAPQYVSSpDGoFLDSlIQNGYAFoDRYDluMSKsNKYGot-DLhcAlKALHupGIpsIADWVPDQIYNLPGcEVVTATRsssaGchpssupIcpoLYVupo+osGpDYQupYGGAFL-ELptpYPplFpppQISTGpshDsS.KIppWuAKYFNGoNI.GRGAtYVLpD.uospYasls...sstsFLPKpLssppups.GFspDGp	...........................................................LLMsWWPsKpTQlsYLNYMsp.shhs.........ss....aospssQstLstAuptlQhpIEp+Iu.tp.tsTpWL+phh.......ssFVcTQspWNhpoEs..........sspD.HLQGGALlasN.ss.......h.......Ts.ANS.cYRLLNRTPTsQsGp...phh...sp....GGaEaLLANDlDNSNPlVQAEQLNWLaYlMNaGoIstsDss..ANFDGlRVDAVDNVsADLLQIsuDYF+utYtlsps-tpA.pHlSILEuWSpNDs...tYsc-pssspLshDsth+huLlauLs+.................s.s.R...u......s..lpshls.....................ss..Lss.Rs.p-.s.ppspshsNYsFlRAHDSE...VQslIup..I......Ipcpl..s.s.s.s.sGhoh.....Th-plppAFcIYNtD.ppsc..KcYTpYNlPuuYAlhLoNKDolsRVYYGDLYTDDGQYMtpKSPYaDAIssLL+uRlKYVuGGQsMps.....sp....p...............tlLTSVRYGpGshsAsDp....Gs.s.pT.RTpGhullhuNsPsLpLss.cplslsMGsAHtNQtYRslLLoTpsGlstY.sDpss.....h+hTDspG.LhF............s............ss.............-............l............tG........h..pNspVSGYLuVWVPVGAsssQDsRssu.Ss.pts.ssG.psacSsAALDSQlIYE.GFSNFQsass..psspYTNhhIApNs..s..LF+pWGlTSFEhAPQYsSSpDs.....o.FLDSlIpN..GYA....F..sD..RY..Dl...u.......h.......u.p......s.....sK..Y.G.oh--LhsAl+ALHtsGIpshADWVPDQlYsLPGcElVTATRsssaG..p....h..ts.......u.IpppL...Ysspo+usGp.YQupYGGtFL-cLptpYPplFpph..................t.......IS.............oG..p.hsss.KIppWSAKYFNGoNI.G+GuhYVLp.D...uos..pYasls...sst.h...LPptLhsp..s.s..GF..p.............................................................	0	6	14	28
+2771	PF03659	Glyco_hydro_71		Glycosyl hydrolase family 71 	Finn RD	anon	CAZY 	Family	Family of alpha-1,3-glucanases. 	25.30	25.30	25.30	25.30	25.00	25.20	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.56	0.70	-6.00	53	358	2010-01-08 16:12:28	2003-04-07 12:59:11	9	18	107	0	264	391	4	340.70	30	59.90	CHANGED	hVFAHFM...lG.stsh.ossDWcsDhptAptusIDAFALNlu.....sDsaosppLshAapuAs.....pss..FKlFlSFDa....uhWst....spVhshlppYuspsAQhp.hs.GKshVSTFtG.tsuh.........DW.s...sl+susG........hFFlPsapshustshssh....hhDGhhsWtA.WPs...susshssss.........DpsYhpsL.............uKPYhh................PVSPWFaTphss.....asKN...WlapuDs.LWasRWpQlLpL..pP......c..aVEIloWNDYGESHYIG.....Plps........sht......scustp.aspsM...PHDGWRphhs.aIss..........YKsGtt...sshlsp...............-pllhWYRssP.usuC.sussTo.u....Nssstt..thpPs..-hhpDcl..FhsuLLpu.sAslpVo..uGsssphsas.........ussGl.phsVPh....s..sGp.phslsR.sGpslhsssG	............................................................................................VhsHah...lu....s.........sh...s.scatpDhphApt.ttIDuFALNh...u.......-.s.hp......s....ppls...Aa.puAt............phs......FKlFhSFDh.......s..hst...........splhphlppY.....sspsu.hp....h..s......u..+.shVSTF.t.G....t.su.........................................s.W.t.......sl+...p...t...s...u....................haFl.....Ps...apshs....s..t.....th.th...........hhDG....hasWt....u...WP......s.sp...s.....h.ssts................................................Dtta.hphL..............su+s..YMh................PlS.PWFa.Tp.hss.................as.KN...Wl..a..tu-s...LahpR..Wppllp.h..........pP........p..hVpIloWN.................DYGESHYIG.....Plts..th.............stus.p.as..t..s..h....s.........HsuWhphh..aIshYKsG........shlpp..................................................-tlh..hWYR.ps..s.ss.ss.ssos.s..............tPt..phhpDpl..ahsshLpp...suslp.lp...uuss.t..thp.........sssG.h.thplsh....s........sGt....hpl.R.sst.lhp.....................................................................	0	88	143	218
+2772	PF03662	Glyco_hydro_79n		Glycosyl hydrolase family 79, N-terminal domain 	Finn RD	anon	CAZY 	Domain	Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment.  Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form.  Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity [1].	20.50	20.50	20.70	20.70	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.93	0.70	-5.81	9	293	2012-10-03 05:44:19	2003-04-07 12:59:11	9	9	99	3	160	323	6	232.70	31	49.33	CHANGED	sccuolslpGpstIApTDEsFlCATLDWWPP-KCsYspCsWGhASlLNLDLss.ILhNAIKAFsPL+lRlGGSLQDpllY-sGc.cpPC.ssFpKsoutLFGFopGCLshcRWDELNsFFppTG...................................AhlsFGLNALpGRsh...hsc.........u...shsGsWDaoNApshIcYTlSKGYs.IcuWELGNELSGSGVGA+VuAcpYApDsIsL+sllpplYpss.tspPlllAPGGFFDtpWaTEhLpposss.lcVlTHHIYNLGPGsDs+LIcKILDPSYLDt.upT.FpslpphlpptGohAsAWVGEuGGAYNSGtchVSsoFl.SF...WYLDQLG	..................................................................................................................................................s.......................................................................................................................................................h......hsh.....p.p..hD.L.sFhppoG...................................hpllFGLN.ALhtp..........................sstWssoNAtthlc..Ys.ssKtYs....I.uWEL.......G.N..E....s....u....p.t..h..s.........h..t..lsu....pQhucDhhpL+p.ll.p..p..h..a...pp....s........t....P.l..htP....t.s.......h......s...............p....hh........p.p....hlpt...uGt.....l-slT.aHh.Y..........l.ss....t....t...........th.h..pc.....hLsPp....h.LD.p...h..pp...hp....pl...phl.p.p...hss......t.t.....tsWlGEs.....uuAasuGt..lSssFssuF...haLDpLG........................................	0	43	82	120
+2773	PF01270	Glyco_hydro_8	Glycosyl_hydr20; 	Glycosyl hydrolases family 8	Finn RD, Bateman A	anon	Prosite	Domain	\N	17.50	17.50	18.70	17.50	17.00	16.00	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.11	0.70	-5.72	7	1235	2012-10-03 02:33:51	2003-04-07 12:59:11	12	23	1064	33	227	966	30	329.70	32	84.54	CHANGED	hshshtsshshshhsshssstsutss....tW-paKucalpssG.......RlhcsusuNhsps......EGQGYGMLhAVhhs.....-pshFDsLapascspLpp..hsstLhuW+hssstps.hts...ssATDGDh.IAauLLhAtKpWt.st+hshhp-Ahshhht.hhshhs..sG...sLhPGshGhsps..hthNPSYahhPsht.tFhshTusstWtslh-cshpllspht....upsGLssDWlshs...sssu.t.th-.......as.phShsslRlsh.hhhhs.....spsshlssaht.....hhpshhcshp.shssluostsusas..hssGhhAspssshtp.lss.....thsph.suu......csYausolpLhshlhpst	....................................................................................t.s.tt.ts..s...........tWcpaKpcal.s..ppG..................RVlDs...u..s..u...pp...s.o..S........EGQuYGMhhAlhAs.....D+ssFDplhsW.Tps..p..Lup................hp...p.....p.....L.......AWha.......u..p..........c................p..s..s....phps...........sNoAoDGDlahAauLLcAu..+h.....Wp....p..t..p...Y..s.......hup.Alh.h..........ths.....t.....c.s.............s.......s........l.....s....hG...................s............h..........L.............LP...G..p......h....G........F.....s.....p....s.......s........t....h..c...............h.......N.....P..........SYhs....P....p....lt....p....a.a....s.....t....h.......u....s....s..........W.p.s.ltcssh.c...lLh.csu............s...pGhsP.D..WVthc......tstu.h..p.......t..sp..................hshhu.SYsAl.Rl....h....h.....ahu.....hh..s.....c.......s...s.........pp...u....c...h...ls.pFts..........hssh....s...t.....s..G.h..s.s.p.t...ss.....l...s......o...s..p...s.....t...s...hs..........P....s..G..h...u...A.s...h........s.....h....h....p...s.h.ss.p................ph.s..t...h.sts............csYYs.sL.sLhu.hh..........................................................................................................................................................................................	1	80	127	172
+2774	PF03639	Glyco_hydro_81		Glycosyl hydrolase family 81 	Finn RD	anon	CAZY 	Family	Family of eukaryotic beta-1,3-glucanases. Within the Aspergillus fumigatus protein Swiss:Q9UVV0 two perfectly conserved Glu residues (E550 or E554) have been proposed as putative nucleophiles of the active site of the Engl1 endoglucanase, while the proton donor would be D475. The endo-beta-1,3-glucanase activity is essential for efficient spore release [1].	25.60	25.60	25.90	25.90	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	695	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.17	0.70	-6.52	5	477	2010-01-08 16:09:34	2003-04-07 12:59:11	8	36	230	0	313	469	76	526.10	26	69.41	CHANGED	sPshsc+ShhPsPsphhusDpsssPLpTNKFYsNhhLsss-QPpasHPYSIp.sssSS.aGLAISHsosSQpsah..ssossspalFNPsGltshVFoA+pFsSusslsl-ppchpphpssLSsossoSsalchPLVpGMGFlTulY+.sLsFsls.SSIsFSTIhu.pSlShupuhsKYsIpLsNNpsWLlYAoSPs...spsFsLTlsusSoIpsSsuFoGLIlQIsVlPs-o..NsY.EslhDtuAGsYsssscLsuspsDupsscYcFsasstGYot.GssLMaALPHHhpSFos.-sQsphluptLsSTlcGlMsGYlTcSWsL.csplspplua-PVSlohsSpt.sYSc-uLpcItuAsspDVNsssSsAESslsS.YFhGKlIA+YAplsLlAcEIlaD-slTKpsLpplshAhshLsuNpQshPLlYDsKWsGlISou..GSpSSpADFGNoYYNDHHFHaGYalYAsAVIuhlDP........oWucc.NRcaVpoLlRDa.....ussucSDoYFPphRsFDWFsGHSWAuGLaEsGDGKNEESTSEDVNuhYAsKLWGLshGDo+LlspAsLhLolh+cAhpsYahhcsssoVpPc-FlG.N+VoGILFsNKlDauTYFGscEa..hhpGIHhlPlTPlSuhlRSs.oFVKQ-WNtKlsPII.-oVu-GWKGILauNpALYDPcsAYcpFus.ssFDsuNpLDNGhShTWaLAh	.........................................................................................................................................................................................................................................................................................s..h....Tstah....thh......h......t..t...........h..Ph..h..................................................................h.h.................................................h.....................t..h....................h..........................................................................h...lhpG.saho.............................h....h......h...................................................................p.a.h..h...s...t......ahhY...........................................h.............t...........h...s.t.....h..G.h.hpls......h............t........t........................t......h..h.D...t.ss.h.a...s....htsp...h.........p.....h.p.................t............t.........hpa..p.......h.thtt.t.....G................t.....t.....h.l.h.hA.h.PHHhp.h....................s.........t...t.t...t...........h...s............h.sohcG.hhuh..h.......s....s.......p......h.h.p.................................h...........P.h.............................p...............ths.t.....t..t.h.t.....lht.h.h.p-.l....p...t.......tt..ss.s...o...Ya.GKhls+hA.lhhhs...p.............p....l....h...t...........s..p...s.....h.s....p...........h..h..........hh............p.t.h.hthhh.......s..........s......p......t......t.......s.....h.h.YDstWtGl.lop................................................s........t........hDFG.s.s.h.YNDHHFHYGYalhuuAllupl....Ds.......................sW.....h..pp..........p....s....h...lp...LlRDh...................u.N.s..s..p....s.DshFPhhRsFDhatG.HSWAp.G....l.....h.....t..s..D..........G+spESoSEshp........hhYu.htlaG........h......s.......h.......Gs........p......phpshGsh.h.......hsl.hpuhppYa................h.h..p..s...s.........s........p.....h..................P..tpa.ht...N+...V.....s.G.....llatsKhsasT............a...Fu...s..t.......hltG........Ip.hlPl.hs.hothl..........ts.t....pa.Vppph..........p..........h......h....t....t...h....h....p......t.....h..t...s..s.....Wpul.lhh..uhh.-.tsu...hphhtt......h.t................h..........................................................	0	91	195	285
+2775	PF00759	Glyco_hydro_9	glycosyl_hydr12; 	Glycosyl hydrolase family 9	Bateman A	anon	Pfam-B_843 (release 2.1)	Domain	\N	20.20	20.20	20.30	20.30	19.20	20.10	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.65	0.70	-5.59	37	1983	2012-10-03 02:33:51	2003-04-07 12:59:11	14	98	574	36	722	2026	39	381.80	25	67.64	CHANGED	sYp-ALpKulhFaEsQRSG+L.PsspR..........hsWRsDSGLpDGss...............h.sl.......DLoGGaYDAGDpVKFshPMAaosThLuWushEatsth................tpusplsphhcsI+WuTDYhLKspsu.ss......hasQVGD.....GssD........Hph....WttsEsMshsRssa+lstssPGS-luuEsAAALAAASlVF+ss.DssYuppLLppA+plasF..AcpaRutY...Ssuh.ss.ussaYsShSGapDELhWuAAWLahATs-.....soYLshhps.stphtsts.................sasWDsphsGuplLLA+h.h......p....hppa+sp..s-palsthhss..s.sp...sphTPGGLhah.pWus..LpYssssuFLhhsYuch............s.hssssphpshAcpQlDYlLGsNPhphSYlVGaGsp.PppsHHRs.s.....s+.......suapshhssssPp.phLhGAlVGG..Pss.....................pD.sasDcRssYspsEsAsshNAuhlGsLA	...............................................................................................hh..shha.a.hp+.....s..................G..............................a.tts.u...sh..Dtt.................................................................t.............DlsGGaaDA..G..D..hs..K.........ashs..huh...........o...........s.s.......h.......L....sash.hEhttth.........................tss..s...p..h......s.....c.....hh..ctl+WshDahl+hpst...t.......................hh.h.p.l.....us................ut....sc..............Hth..................Wt.ts..p.....s........h...........s..........h........t.........c......s....s...h......p.....h.....s........t.........p....................u..........o.......s......h...s.u.p.h...A.A....u....h.At..u........u..h......la....+........s..................h......-....s.....s...a..........u...p.p................hLptAc.........p.....hap.a......A...p.....p......h....t...s...h.....................ts..s..............s........s..........t..s.h..Y........ss....s....s...ht.....D.........E......h............hW........AA.s.La.h.u...T...t..p...................pp....Yhphhtp.....h...tt...ht.h.t.t.......................................hsW.sst...h..s..s..st..........h.h..........h...uph......h...................t.................hptht..pt..............s..p..t........h..........hs.thh.................................tt......h.......hs.............s...........t.......Gh.........h....h....h..........h.us....hphs...s...s..s...h.h..l..h..h.ha..s.............................................................................hhtspphh..p.h.A.p.p..p.......l.....sYlLGp........Ns..h...t.h...Sa...h..s...G...a..........G...t....p.........P.............p.p...H..HRh.......................................th.t.h....t......s................Gs....lsGG....P.s.t...............................................tc..ta......D.....t.....h...t.....sa....s..Essh.hN.Ashhhhh....................................................................................................	0	310	549	663
+2776	PF03808	Glyco_tran_WecB		Glycosyl transferase WecB/TagA/CpsF family	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.40	25.40	25.40	32.20	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.77	0.71	-4.86	167	2497	2010-01-08 16:18:29	2003-04-07 12:59:11	8	24	2143	0	522	1664	434	170.50	35	65.78	CHANGED	phlppAcllhsDGhullhuu+hh.u..tsl.........cRlsGsDlh.tLhp.tsspp.sh..plaLlGup.slhcpsspplpppaPslplsGhpsG...ha.........s.t-p.ppllp...pIpp.ups-llhVuhGsP+QEhaltchtpp...lsss.lhhulGusaDhhuGp.hcRAPpahp+huLEWlaRLhpEP...pRlh+c	..............................p.hlppA-hlhsDGhulVhus+hh...s.....psl.............pRVs.GhDLhppLhp..huspc...sh.........pVFLlGuc.s......-...........V......lp.psttpLppp...a.s.slsl....sGtpc.G..YF............p.cccpslhc....cIpt.uts.cllhVuhGs.PKQE.haltcpcpt........hsss...lhhGVGGoaDVhuGp..lKRA.PphhpphsLEWLYRLlppP...pRltRp........................	0	167	342	432
+2777	PF01531	Glyco_transf_11		Glycosyl transferase family 11	Bateman A	anon	Pfam-B_935 (release 4.0)	Family	This family contains several fucosyl transferase enzymes.	21.50	21.50	21.70	21.60	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.12	0.70	-5.43	5	654	2010-01-08 14:30:42	2003-04-07 12:59:11	11	14	365	0	223	638	1259	248.30	22	78.41	CHANGED	sVSllh+spptlsLh.AsWAh......Pshss.s.p+hsu.hcGhaTlslNGRLGNQMGpYATLhALAp..hNGRhAFIPsuMHusLAPlFRIoLPVLpscsupRpPWpNaHLsDWMcE-YcclsGcal+hoGaPCSWTFYHH.LRQpIcpEFTLHDHLREEAQ..shLRsLpls.h.GsRPSTFVGVHVRRGDYVcVMPKsWKGVVuDpsYLppAlDcFRARasuslFVVTSDDM-WCKKNIcsSpGDVsFAGcG.puSPuKDFALLoQCNHTIlTlGTFGaWAAYLoGGDTlYLANaThPDSpFhslFKPEAAaLPEWlGIs	.....................................................................................................................................................................h............................................................................................................................................................................................................................................................................................................................................................................................................h......................t......h...a...h....t......hhp.p....h.............h..php...s.....pl......p.......pt..hp.................th.h...p.t..h..p..ht.........h.....p..s.....p..s....h...V..u.lHlRRG.D..Y.lpsh.......t...........h..t..s.hss...h.s.......Y...h...p..pA....l...c.h....h.....p...................t.....+.......h....p....s......s........h....F...hlh...S....s...-...hp.W..........s....+....c..........s.....l.......s.....h.....t........p..........s.....p....s.......h....h.sss.......................tss..s.hp...Dhh.L.h...o.p..C...pasIh..s....s..STFuaWu.Aa.L.s......t..s..s.p...l...h.l...h.s..p.h.....t..p.................t.h..tW...............................................	0	67	103	167
+2778	PF01793	Glyco_transf_15		Glycolipid 2-alpha-mannosyltransferase	Bashton M, Bateman A	anon	Pfam-B_1324 (release 4.2)	Family	This is a family of alpha-1,2 mannosyl-transferases involved in N-linked and O-linked glycosylation of proteins.  Some of the enzymes in this family have been shown to be involved in O- and N-linked glycan modifications in the Golgi [1].	25.00	25.00	37.10	25.60	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.12	0.70	-5.49	107	719	2010-01-08 14:40:35	2003-04-07 12:59:11	11	10	156	6	528	697	49	307.20	39	74.37	CHANGED	lhh.shhttttp.......................tttttts.tpt.thpth...tpstst.h..tttt...t.............................s+....NAThlsLsR.Np-...L.sllpol+slEcRFN++..apYsWlFLNDcPFo--FKctspshs.Suc...sc.........auhIPcEcWshPsaI...Dp-+hpcshcphtccpIhYGsspSYRpMCRapSGaFa+cslLpcY-aYWRVEPslchaCDl.sYDsF+aMc-ssKpYGFsIulh.E.h.pTIPTLWspsccFh..pppPp...altp.sNhhsalo-..s.....................................................................................supsYNhCHFWSNFEIusLsFaRSc...............s..YpcaF-aLD+sGGFaYERWGDAPVHSIAsuLhLc+ccIHaFcDIGYhHsPa	...............................................................................................tt...............................................................................................+.sAshls.LsR..N....p..-....LtsllpSl+pl..............Ec+FNcp..apYsWVFL.....N..D.tsFs-.-FKctsp.shs....su..p....sp..................aGhI.....P..p.....-.c.Ws.hP.s...aI...Dpp.....p.hpcshp.pht...c..pt.........lhY.G..s...p.SY.+.pMCR.F.S....G................aF..a+H..s.lL.p..p..Y-aYWRV.......E..........Pslcaa.CDl...sYDsF.p.aMpcssKpYGFslulhE..h.pTlPo...LWpp.spcFh...cp..p..sp.......hl....t.p....ss..hhpalo-..c.............................................................................................tupsY..N...hCH....F.........WSN.FEIusLsaaR.Sc...............t..YpcaFpaLDc.sGGFaYER.........W................GDAPVHSIAsuLhLs+sc.I..HaFcDlGYhHss................................................................	0	147	304	462
+2779	PF03076	GP3		Equine arteritis virus GP3	Griffiths-Jones SR	anon	Pfam-B_687 (release 6.4)	Family	This protein is encoded by ORF3 of equine arteritis virus. The function is unknown.	25.00	25.00	291.00	290.80	20.50	17.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.12	0.71	-4.40	3	141	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	2	0	0	140	0	161.00	84	98.16	CHANGED	MGCTYSGPAAFLCFFLYFLFIsGSVGSNNTTICMHTTSDTSVHLFYAANVTFPSHFQRHFAAAQDFVVHTGYEYAGVTMLVHLFANLVLTFPSLVNCSHPVsVFANASCVQVVCo+lNSosGLGELSFSFIDEDLRLHIRPTLICWFALLLVHFLPMPRC	...MGpAYstPVAhLCFFhaFLFIsGSVGSNNsTICMHTTSDTSVHLFYAANVTFPSHFQRHFAAAQDFVVHTGYEYAGVTMLVHLFANLVLTFPSLVNCo+PVsVaANASCVQlVCs....p....s.N...So....s....G....LGElSFSFIDEDLRLHIRPTLICWFALLLVHFLPMPRC.	0	0	0	0
+2780	PF04724	Glyco_transf_17	Glyco_tranf_17; 	Glycosyltransferase family 17	Mifsud W	anon	Pfam-B_5914 (release 7.5)	Family	This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression [1,2].	21.70	21.70	23.20	22.00	21.10	21.60	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.45	0.70	-5.45	12	306	2010-01-08 16:27:10	2003-04-07 12:59:11	8	5	175	0	202	296	1469	291.40	27	74.31	CHANGED	hhshS+h+sh.+th....hh.hhhhh.hslhslhh+tpplohhhRPlW-uPPp.FstIPHYatcNhoM.sLCpLHGWthR.-hPRRVaDAllFSsEhDlLplRa+ELhPYVspFVlLESNsTFTGhsKPLhFtp..p+sp.FcFlcs+lsYshlssh.hcpGc...sPFltEuYpRsAL..ctLlRluGlpsDDllIMuDsDEIPStcTIphL+WCDshPplhHLcL+pYLYSF.....................pa.sDspSWRAohHhapsG+TcYtH.RQosplLsD.........uGWHCSFCF+.lp-FhFKhpuYSHsD+sRascY...Ls.cRIQclICpGsDLFDMlP.EEYoFp-lhtKhGPlP.ohSAVHLPuYLLcNh-cY+aLLPGNChRcu	.........................................................................hh.....................................................................................h.............h.....t.......s......R+....lhDshhh.s.s..E.lDlL.-lRhpELhshVDhFVl.lE.Ss..h...Tap.G.h...KsL.hFtp....pp...tp..F..p..h..hc...s.Kl....h..Y.h.......h....l..s.........th......................t..up..............ss..a.........t-.s.....a..p.....R...s.....tl................ptl.h....p.....h..t...s........h.....p....s...c.D..lll.huDs.DEIP.s.....cslthL...+h..tc.....shs....p....h....p.hp.h.+..hY...uF................................................a....h.....ss..p....h...p....t.......t......t..h...h..........s...h.p....p.h.....t...........p....p..s.s...t...l..lhp......................uGWHCSaCFp..p.....ph..h.h...Kht...u..h...sHs-.h....p.h.tta.............hs.p.hI.pphlppGt.haDh...p.h.....................P..h.......................................................................................................................................................................................	0	73	120	165
+2781	PF03033	Glyco_transf_28		Glycosyltransferase family 28 N-terminal domain	Griffiths-Jones SR, Bateman A	anon	Pfam-B_1105 (release 6.4) & Pfam-B_2764 (release 7.5)	Family	The glycosyltransferase family 28 includes  monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.42	0.71	-4.41	43	6160	2012-10-03 16:42:30	2003-04-07 12:59:11	15	40	4548	35	1693	4850	1858	138.00	25	33.17	CHANGED	lllsssGTtGcl.PhlAluppLpcpGacVp...luspsshpphl..ppsGlshhs..lsss.....................................thht...hhpthtsshpt..th.thhphlt....phshthsshhussshhush.....htthshhltEp.ulPhhssphhshhssphhh	..............................hllsuGGT.u.G...HlhPsl....Alupp.L....p......p.................p......G.........a..c...lp..........hlGop.....s...s....hE..pp..l.....h.p..p.......G.....l...p.......h.ps........lsss..........................................................................................s.hpt.hh............h...p....t.h..t....s....s.hc.h......h......p..u..h....h.p.....u..t..p....l.......l.....p...c.......h.....p.......s...c....s.....l......h...u.........h..G........G.....a........s....u........s......P....s.h..lAAh...........hhtl.P.s.llHEpsuhsGhsN+hhsphspph..h........................................................................................................................................................................................................	0	541	1110	1453
+2782	PF04666	Glyco_transf_54	GnT_IV_N; Glyco_transf_55; 	N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4541 (release 7.5)	Family	The complex-type of oligosaccharides are synthesised through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide).  In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein [1].	19.90	19.90	19.90	20.00	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.72	0.70	-5.68	18	495	2010-01-08 16:26:41	2003-04-07 12:59:11	8	9	124	0	316	424	6	244.80	33	57.08	CHANGED	tths..........hpthpsssppl.pplsp...........phhh.hhsH.....hhcctu......slpPslltGpsRssVu.lVlGlPTV+Rp+poYLh-TLpSLlsphot-Epc-sllVValA-oD..salpplspplppcFspclpSGhl-VIusstpaYPshssL+coasDsp-RV+WRoKQNLDYuFLMtYApscGpYYlQLEDDllsp+sFhsshKpFssppsu......pcWhhLEFSpLGFIGKlF+SpDLspLlcFhhMFYp-pPlDWLLsHahhl+sC..tt.s...C.t.hpphhIRa+PSLFQHlGtpSSLpG+.hQ+LKDc-F	.........................................................................t.t...........................................................ph....th.hu...s..h..pt..hp...lslGlso....VpR.....p..t..t....s.YLhpTlpSLhppho.pEpp.....chh..ll..V..hlu-............sD....p........a........h.pths...tp...lp...p.Fspc.l.uGhl....lIpss..paY.P.s..h....s..p.l+....p....shsD..s.p.cRs..paR..o.KQ.N.lDYsaLh...a.s..p.s..p.u......t.YYl..L.EDD.lhsp.s.a..hsph....+phhhp...hps............................ppWhhLE.F..SpL.GaI..G.K.......h..a+u..DLshlspFhhh.F.Y.p-hPhDaLLschhh.lhs..............................tp.hlpacPSLFQHhGhhSShtup..p.hp................................................	1	73	104	181
+2783	PF03414	Glyco_transf_6		Glycosyltransferase family 6	Bateman A	anon	Pfam-B_4383 (release 6.6)	Family	\N	25.00	25.00	25.80	25.50	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.11	0.70	-5.98	6	613	2012-10-03 05:28:31	2003-04-07 12:59:11	8	8	118	121	171	620	297	246.90	53	92.10	CHANGED	htPpVhssphthshWhsthhpsshp........s.phppsctc.ccppptscl.cplp.pshh.s.pRs-VLTlTPWhAPIVWEGTaNpAlL-phYthQplTlGLTVFAlGKYlc.aLccFLESA-+aFMVGH+VhaYlhsDDsuchPhVpLGPhRplpVhEl+scKRWQDISMhRMcTIu-HIht+hpHEVDaLFChDVD.VFpD+aGVETLGpLVApLpshaYtAs.psFTYERRc.SsAYIPhsEGDFYYtuAlFGGosscVhplTptCapuILtDKtNsIEAtWHDESHLNKYFLhpKPoKlLSPEYhWD.+l.GhPuslKpl+hoh.sKpashVRN	........................................................................................................................................................................pluhhhhAh.t.....+Ylt...FLc..hFLEo....AE+aFMVG..HRVp..YY.VFTDpsus.V.P..c..VsLGsGRpLsVlcV.pu.h.p.RWQDlSM+RMEhIu-ahccR.hhpEVDYLhChDVDhc.F.pD+lGV.ElL.......s...s......LhusLHPu.a....Ys..ss.RcsFTYERRPpSpAYIP..psEGDF..YYhGuhFGGoVp-V.+LT+sC+puhhhDpsNuIEAhWHDESHLNK.Yhlh.p.KPo..K.lLSPE.Y........hW.........D..ph.s..ss..l+hh+h.h...K...................................	0	7	24	62
+2784	PF01075	Glyco_transf_9	Heptosyltranf;	Glycosyltransferase family 9 (heptosyltransferase)	Finn RD, Bateman A	anon	Pfam-B_839 (release 3.0)	Family	Members of this family belong to glycosyltransferase family 9 [1].  Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.29	0.70	-5.16	18	6767	2012-10-03 16:42:30	2003-04-07 12:59:11	12	124	2063	9	1547	5234	3651	225.80	19	64.03	CHANGED	htpLtcsLppps.aDhllshpshlKSAhlsthhutsh+hGhctpot...husLhhs+phshsh.tthtVpRhttLhsps......hshstspspsphslshtptsttpsths............ttPhlshhPuuot....ssKpWPt-patcLsptLpcpG..hplhLhsuspc...-cppscplssuhc........hsslssKhsLppsstLlutAshlVusDoGLhHlAAALs+PllulYGsTsPthTs....Phucptssls..phtttsshpppshhsphp	.........................................................................................................................................................................l.pt.tt.aD..hh.h.......s....h..............s...............h.......p..s....s......h....l.....s...h...h....h....t.............h........h...p..h....u.....h...t..h..t.t..............................h..........t....h...h.....h.....................................................h....l....p....p............h...th...hh...............................hs..h........................................h........h......s.....t......h..t......h.....t..hs........................................tt...h..l.sh......t...s...u.....uph........ssKp......W...s.....t.......p.p....a....s.p.l.h...p....t...l..t...p....p......s.........hp........l...l...L..h..u..uspc............tpp.h...h.p...t..l.s..p..t.h.t...............................shs.l.....s....s..c...h...s....Lt..p....h....s....sllsp.u....c....hhlusD...oG.hH...lAu...Al.s.p........P......s..lu.l.........a......G...s......o.....s.....s...t...h..hs...............sh....s....t..p........h.......h............................................h.................................................	0	478	953	1279
+2785	PF00274	Glycolytic	glycolytic_enzy; 	Fructose-bisphosphate aldolase class-I	Finn RD	anon	Prosite	Domain	\N	19.20	19.20	19.30	19.20	18.10	19.00	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.02	0.70	-6.05	58	2226	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	1445	193	546	1888	2485	252.40	41	94.39	CHANGED	ELhcsAptIsuPGKGILAA.D..ESsGThGKRhssIGVENTE-NR........RtYRpLLFoo.sslsphISGVILF-ETLYQpss-.GpsFV-lL.+cpGIlPGIKVDKGllsLsGoss.EosTQ........................GLDuLucRCApYhKsGA+FAKWRsVLcI.....s..sssPSpLulpENApsLARYAuICQpsGLVPIVEPEILsDG-HclcpstpVTEcVLAtlaKALsDH+VhLEGoL.LKPNMVTsGpsss.p..+.soPpplAhhTVpsLpRoVPsAVPGlsFLSGGQSEE-AolNLNAhNph.............sh...+PWtLoFSYGRALQsSsLKsWtGKsEN...lpAAQcthlpRA+ANutAslG+Yssss........sssuspoLaltsasY	.........................ht..upGhlAh.D...pS..suoh..sK..thtth.s.....l...p.........ps.p.sp..............+thRphlho....s....s....h...............ht.ph....I.G....sILFcpTh....p.t.......p.....G..h...........hsphl.tppGllshlK....VDK........Gh.ss...h.s..ss......st...pshp........................GLDsLh.cR.s.s..p.ah.h..GspFuKWRsVl...pI.................t.PS.thuIt.-sAp......sL.ARYAslsQp..pGLVPIlEPElh...cu...p...H...chctpthlpppl.httl.ph.t-p.pVhLc....hol.hcsshh.tsh...............tp....................................Vst..........lshLSGG.S.....c-cAs..Lst.s.th............................hSauRALtts.lth..tsp....t.................................................................................................	0	175	303	423
+2786	PF01102	Glycophorin_A		Glycophorin A	Finn RD, Bateman A	anon	Prosite	Family	\N	22.70	22.70	22.80	22.70	22.60	22.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.65	0.71	-4.35	5	139	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	43	6	29	143	1	95.20	40	58.86	CHANGED	HT.SsSGSso.t.ISo.......oNDspspsStuTP........TtspEVosthssRsh.P.EpG..-slQLsHDFScsVITLIIFGVMAGlIGTILLISYsIRRLIKKSsuDVpP............hPsP..tDs-VPLSSVEIEsPE-	..................................................usss.t.los.......sssppppsohsss........stsp.cs.S.plo.sps.l.sspp..p....-p..s....Q....lsH.cFots.......I...hhIlhsVhAGl.IG..hI..L....lI.YsI....pRhhK..........................................................................................	0	10	12	18
+2787	PF00606	Glycoprotein_B		Herpesvirus Glycoprotein B	Bateman A	anon	Bateman A	Family	This family of proteins contains a transmembrane region.	18.80	18.80	18.80	19.50	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	714	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.34	0.70	-13.22	0.70	-6.50	40	1279	2009-01-15 18:05:59	2003-04-07 12:59:11	13	17	240	20	36	932	2	309.30	28	74.43	CHANGED	phsFRVCus.usGu-llRFptspsCPs.hspscsasEGIhllaKcNIsPYpF+VphYhK.lThsosasGh.shs..tlospasc+hPlPhhElst.IDppspChSusphsp.sshhhssac+Dsh.spsh.LhPschtosss+RahTss-hYss.Gsh.hhY+osToVNChVs-spARSsaPYcaFshuoGDsV-hSPFashp..ssp.hs....csss+Fp.lcsYphlDhtsc...hstsssspRsFLppsc.hTluW-htscpsssCshshWcp.hscslRsEts.sSaHFsupslTATFlosh.sphshsps...pthsClpccspctI-clatpcYNsTHlpsGsl.p...hYhTsGGhllsaQPlhspsLschhttphspsssssss.t.........................Rp+Rsssssstt......................................shpopssltaAQLQFsYDpL+salNchLuclAcAWCcpQpRpthlWpELoKINPoulhSAlaG+PVuA+hlGDVluVocClpVsQso.VplppSMR........lsusss....hCYSRPlVoFcahNsop................................hhpGQLGpcNEILLspphlEsCphssc+YFhsGsshhhYc-Ytas+plsls-Issl.sTFlsLNlohLENhDFpsLElYo+sEl+so.sVhDlEplhR-hNhasp+ltslcpslps...sspsshlpGlsshh.pGLG.slGculGsVluuluGAluShVoGlsoFlpNPFGuhslhLlllAsllslalhaR+hppltpsPlchLYPhss...p...shppps	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.hRph.t............................................p..psh..hu.....lQFsYsplpt.lNphhtpl..uWC..Q.+p..hh.th.pl.........................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	12	36
+2788	PF00802	Glycoprotein_G		Pneumovirus attachment glycoprotein G	Bateman A	anon	Pfam-B_1049 (release 2.1)	Family	This family includes attachment proteins from respiratory synctial virus.  Glycoprotein G has not been shown to have any neuraminidase or hemagglutinin activity (Swiss-Prot). The amino terminus is thought to be cytoplasmic, and the carboxyl terminus extracellular.  The extracellular region contains four completely conserved cysteine residues.	20.70	20.70	20.80	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.95	0.70	-5.24	4	4325	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	47	1	0	2618	0	121.00	55	83.44	CHANGED	hKTLc+sWcs.pahIVh.SCLYKLNLKSlsQhALSsLAMIh.TSLlIsAIIaIuouNpKspsTosss.phTpQhpNpTosahTpps.puspsSpQuTTos..pThssssT.Gs..phtHoTspTpsppT....T.stspKPshpsptspPPcp.pDc.cFplhsaVPCSICpsN.sChSlC+phspptPsKtsThpPpKpPpsKTT.KKsoKT........oTp+.Tp..ThhpsKsNhoTP..slLoosp..............................HsTs	.............................................................................................................................................................................................................................K+D.Ks.spp.PK..c...sTTpP.T.cKPThp..TTcpshpT...TlLsosTotp.E+.................T.QppoLHSTo........................................	1	0	0	0
+2789	PF02885	Glycos_trans_3N	glycosyl_transf_3; 	Glycosyl transferase family, helical bundle domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Domain	This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase.  All these proteins can transfer a phosphorylated ribose substrate.	20.90	20.90	21.00	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.75	0.72	-4.38	135	7326	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	4261	62	1772	5253	2054	66.00	26	16.80	CHANGED	phpphl.cclhpu....psLoppEspthhptlhsGphs...........cspluAhLhAlph+G...pos-ElsuhscAh..tppup	.......................pllp+h....tcG.....psLop-Ehpthhst.lh.....s..G.p.ls.........................-hQl...uAhLhAlph+G....o.pEl.suhspAMhppu.............	0	546	1116	1479
+2790	PF00534	Glycos_transf_1	glycosyl_transf_1; 	Glycosyl transferases group 1	Bateman A	anon	MRC-LMB Genome group	Family	Mutations in this domain of Swiss:P37287 lead to disease  (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety  of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP,  GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.91	0.71	-4.84	63	44775	2012-10-03 16:42:30	2003-04-07 12:59:11	15	435	6658	103	12903	42366	19227	161.60	18	38.27	CHANGED	sppp.ptphsh.psphhllhlGRlthp.KGhchllcAhttl.t.........tsshpLllsG..........tsp.ppphpphspphtlpsplhhhuhhs..pclhphhpt....uclhlhsSth....................EuFGhshlEAhusGhPllsos.ssGhs-llpcst........sGhllpss...sscslsctlppllpsp.......phppphsppupph	..............................................................................................ht.................p..t....h..l..h...h...l...u.....R....l....t...........p....K........s.......h....p....h....l......l.....c.......u...h.tp....l.....................................t..s....h........p....l...h....l....h....G................................................pss....t...t....p...h....p......p.....h.....h......t........p...........h...........t..........h................t..............s................p...........l.........p....h...........h........G......h...........h...........s.............................p..........l..t.....p....h......hpt.............u-..l....h.......l.....h...s.S.hh.........................E...s.....h......u.....l....s....h....l...E......A.h....u.t....G....h.....P........l..l....s....s.....s........s.......s..........u........h......t.....-........h..l...t...s.st..................................sG....h..........h....h..........t.........st..........s............................p..............s...........h....s....p....t....l....t....p....h...h....t...p..........................h........................................................................................................	0	4440	8647	11076
+2791	PF00591	Glycos_transf_3	glycosyl_transf_3; 	Glycosyl transferase family, a/b domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Family	This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase.  All these proteins can transfer a phosphorylated ribose substrate.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.42	0.70	-4.98	21	7137	2009-09-11 15:42:01	2003-04-07 12:59:11	16	28	4318	62	1734	5172	3200	239.20	30	60.81	CHANGED	shshlDhsGTGGDGtsThNlSTsuAhVsAAs.Gs+lAKHGNRulSSKSGouDlLEul.Glsl.phss-psp+slc-sGluFLFAPtaHsuh+assssR+pLsh+TlFNlLGPLhNP.ApsphpllGVast-LspshAcslppl.shp+uhVVHG.sG.....hDElohtupThVsclc.su...clspaslsPpDhGlppsplpsLpusss.cENtchlc.slLpGpsssh.....t-hlshNAushlhluGhsso.......LcpGsptAt-slcoGpAh	.......................................s..hlDhpuTGGs.G....ss.o....Shss...A..llAus....G.l......h...........VuKp..u..s.R.u.l.u......s.p..u.G...o..h..D..hL.Eul....G.....h...p..l..ph.ssc....phtc.........h..l........p..c..........s...G..l..u..h..l....h..u..s..s..h.h..ss....h.c.+.h.h..s.c+...-l....s.s........T...l..s..l..PLlss........................................................ulh.st...clst.s.h.stll...h....c...l......s.....s.....t......pu.h....h.h..........+.....u..............................hD.E.sshh..u........po..h..V...s....hp....sG...........................ph.p...p.h..h.l...o.s.......s...hsL..s..p.s...............h.t.........s...............s.l.c..s.................p...Es.h.p.hLp...shh.tG.t...t.s...................................t-h.lh.h.t.u.u..hh..l.h..h.....u......s......h.....s..p..s.......................lpcuh....thstpslpsGpA.................................................................................................................................................................	0	557	1116	1464
+2792	PF04413	Glycos_transf_N		3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	Waterfield DI, Finn RD	anon	COG1519	Domain	Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides.  Members of the family transfer UDP, ADP, GDP or CMP linked sugars.  The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (Pfam:PF00534).  The eukaryotic  glycogen synthases may be distant members of this bacterial  family [1].	23.90	23.90	24.60	26.30	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-5.13	154	2390	2012-10-03 16:42:30	2003-04-07 12:59:11	11	13	2271	8	551	1796	2084	180.60	36	42.32	CHANGED	htp....chtE...RhGhh............................hlWlH.AsSVGEshustPLlctLtp...phPshplllTosTsTGtphs..pph.....h....s....ps.pta.hP.hDhshslp+FLpphpP.....chhllhEoElWPNllttspppslPllLlNARlSc+Shptap+h.s.h..hhpthlppl..shlhsQsptDupRhhsLGss.pp...lplsGNlKaD.hs..s	...........................................................................hp+htERaGhhtt.h........................ssIWlH....usS.VGE.shAuhPLlctLcp.............c.hP.sh.slhlToh.TsTGt-ps...pph...h...........sp.....slp.phY..LP..aDh.stslp+FLsph..pP.....clsllhET.........ElWP.........Nlltth++cp.......l..PlllsNARLSs+Sh.tsYt+h..s...t...hh+pl.l.ppl..shlhAQscpDupRahsL.G..sp.........p...lpVsGslKFDl..h.......................................	0	170	347	455
+2793	PF01153	Glypican		Glypican	Finn RD, Bateman A	anon	Prosite	Family	\N	25.20	25.20	25.60	25.50	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	558	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-12.90	0.70	-5.90	15	584	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	88	10	343	500	0	364.70	25	92.27	CHANGED	hsl.Lhllhshsu.stu.ssscu+SCuEVRphYt.u+GaulsslPpstIuGEHL+IC.PQGaTCCTscMEE+huppS+h-Fcshlc-uospLpsllsspa+pFD-aFc-LLppuE+oLsphFspsYGcLYsQNuclFp-LFoEL+pYYhGus..l................NLEEhLs-FWu+LLERhF.+LlsPQYp....ho--YlECls+ts-....pL+PFGDsPRcL+lQlTRAFlAARsFlQGLslut-VVs+sspV...shospCsRAlMKhhYCPaCRGl.....sslKPCpsYClNVM+GCLANQAD.LDsEWpsaIDuLltlA-+.lpGsaslEsVltsIcV+ISEAIhshQENusplosKVFQsCGsP+.sssts....husp-t...p+ch+shs.Ec+PTsusss......L-pLVo-l+p+L+ph+pFWsoLPsslCscchsuussssc...CWNGps+u.RYhscVhGsGLsNQlNNP.EVcVDIo+PDhsIRQpIhpL+lhTs+L+sA.................................hsGsDlDFp.Dss.D-sSG.SGSGsusscc....hsssutchshssssspp.t.hsh.................sptssoushspssshhhh..lhsllshhhthh	.........................................h............................................................................................................................hp...............phh..llp.upp.htthF.psat..hh.ps...hhtphasclp.ahh.t.us.....h................................................slpchltcFaspLh.hha..ph.hps.th..................s.ch.pC.ltt...hp....plpsF..GphPp.....lhhp.ht+uh.ssR...hahpuLthu.h-Vhpp.s.tpl..............s..tC.ptl.h+h.aCshCpGh................................pPC.saC.sVhpGChu................t..s.p.ls..Wpth..l..sh..ls.......pt.h.s..............s...h.......-.sh.sl.......hl...p-ul...hpps..t.....pl..s.t...p.......l.........p.h.Cu.s........t.................................t.......p.p...s....................................h.t..h..chhtplp........tha..tLs...lCtp.....p..h....t....t.........CWsG.th.....s...pY.......hh.t..s..tp......Eh....h.p............................p...h..p.h.tLp.h.t..h...h..........................................................................u...................t..................s......t.....................................................................................................h............................................................................................................	0	64	95	210
+2794	PF05199	GMC_oxred_C		GMC oxidoreductase	Studholme DJ, Bateman, A	anon	Pfam-B_891 (release 2.1)	Domain	This domain found associated with Pfam:PF00732.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.74	0.71	-3.90	85	8000	2009-09-10 15:44:39	2003-04-07 12:59:11	8	92	2304	146	3849	7618	4016	132.70	26	23.46	CHANGED	PpSc.GplpLss..s-shs.P.....hl.chsahssst...........D.hpthh....pulc.hstclhpss....................................................tthhshs.......thpssp...........h.thhht...h..shhHss.GTspM.Gts.t.......uVVD.sph+VaGlpsLpVsDuSlhPsh.sssssphsshulA...c+s	...............................................................................................................oc.Gplplps..........tcs......h.t....P..............hl.p.sahs...p...t........................D...hph.hh......puhc.hspc..l.hpp....................................................................................................................................tth..st.........................t.h.tssp.............................h...th.h.tt............s....sshH.............ss.GTs+M...Gs...ssp......................uVVD...s.......p....h.+....Va.......G.............lp.......s.L+.V..sDuSlhPph..su.sNss..sssh..hluE+h...................................................................................................	0	1059	2161	3210
+2795	PF00732	GMC_oxred_N	GMC_oxred; 	GMC oxidoreductase	Bateman A, Studholme, DJ	anon	Pfam-B_891 (release 2.1)	Domain	This family of proteins bind FAD as a cofactor.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.74	0.70	-5.26	20	7804	2012-10-10 17:06:42	2003-04-07 12:59:11	14	78	2279	50	3835	7620	5057	264.90	27	47.78	CHANGED	h-tLatuGGshuos..........................................................ssphhhl.sGpslGGuSsVNhusslRsstpshc-WsschGlphauspchhshhcplp........................tpluV..sspshppsstN..pslhcuuccLGas.t.lscNssus..+.sGhCthG...CtpGtKpuospsaLhsAh.p+.supllossps-+llh..............ttpst+AlGVtspsssss.....hpphhhss+pslluuGAltoPtLLtpSGl.pspc..............lG+NLplHPs	........................................................................................................................................................................................................................DhlllGuGsuGs.slAsR.L.......s.....................p............s...................s.....t.........h.....p..V.....ll.lE....u.G.....s...........................................h...t..h....h..h...........h...........t...........t.......h..........s......h.....t...........h................s...........t.........s......p........................t.................h.................s.......s.......p..........t...........h....................h...................p..G.........+....s...........l.G..G..u..Ss..l..N.u........hh........a...h.........R......s.....p..t.........t........D........a........-........t........W........t........p..................G........t........s........W..........s.......a......p......p....h.h........s...a...a...c.+hE.p.......................................................t..h..p..u...h....s.......G............l.....t....l.............p...................................p.........s....hh..........p............s....h..h..p.........u....s....t.......p....h...G.h....................................h.s.t.....-.....h..s.st.........pt.p...G....h....s.......h....h.....t................................t.....t...................p.............G..............t........R.......h.......o.......s.s..p.......s..a...L............t............s........s..............h......p..........+.................N..............L........p....l..h..s..puhV.p+l..lh..........................................c.....s....p.....+.....A...s....G.....V..p....h..hp.s..stt............................h.p..h...h....s....t....+....-..VlLuAG.u..........l..so..Pp.LL..h...........h........S.......G.l.G.......stt.L....t.......t..h...........s...........l................................h...........h..............p......hs..tVGpNhtDH..t..................................................................................	0	1106	2163	3210
+2796	PF00446	GnRH		Gonadotropin-releasing hormone	Finn RD	anon	Prosite	Family	\N	18.50	18.50	18.50	18.50	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-4.93	0.73	-5.27	0.73	-3.70	25	259	2009-09-12 07:42:02	2003-04-07 12:59:11	12	2	122	0	37	236	0	10.00	83	11.90	CHANGED	QHWSHsWpPG	QHWSaGWhPG	0	2	5	16
+2797	PF03071	GNT-I		GNT-I family	Mifsud W	anon	Pfam-B_2207 (release 6.4)	Family	Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, GLCNAC-T I) EC:2.4.1.101 transfers N-acetyl-D-glucosamine from  UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localised to the Golgi  apparatus, and is probably distributed in all tissues. The catalytic domain is located at the C-terminus [1].	25.40	25.40	25.40	25.40	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.76	0.70	-5.94	4	372	2012-10-03 05:28:31	2003-04-07 12:59:11	10	10	147	7	215	355	35	315.40	31	71.55	CHANGED	hhAshhhhaIthhLFhh.opYA-phssulcucNpssuphph.l.clu.pQsRlVtLEc...hhpp.s--lpplRuhlps..ht.cuhs+lshssthsVhsVlVhACsRAshlc+slcplL+Yp.PsApKaPlhlSQDsucpsV+ptshSY.splTYhpHL..Dhpslss..Puc..hpAYYKIARHYKWALsQlFhc+pFSpVIIlEDDhEIAPDFF-YFcAstsLL-pDcolhslSuWNDNGppQhVcs..P.sLYRSDFFPGLGWMLpppTWcELpPKWPKAaWDDWhRh.Ep++GRQhIRPElsRT..hsFGc+GuShGQFFsQaLc.IKLNDhhVcapphDLuYLhcsNYsKcFsshV.+pAh.lpssclshpshs...cG.-VRlpYcspl-FcchAcphGIh--aKsGVPRsAY+GIVsFphps.RRVaLVsPco.lpthssc.	.................................................................................................................h............................................................................................................................................................................................................................s.hslhV.hAs.sRss.l.+hlcpL...lphp.....s.....s.......s........p.....h...lh.V........D.s........p....p...s.h...p..........h.lt...a............l...p...h.l.pp..........................p.s.l.t.h.....st.................t..............+..lu...p.HY+huLst..hF...p.....h..t..h.......p............t.....slllE.................-DL-l...AsDFFpYFpt.sh..LL...c....p.D.o.la............ClS............AWN....D..............s.G..............h.....pp.hsc...s....................s...p.....h.....L....Y...Rs-hhPGLG.WhLh....+pla.p........E...Lp...PK...W.P....p...s..........h...W..D...WhR.sppR+sRtCIh.P-lsRo...........hp.F.Gh....h............G...h.s.......G..aa....c.t.ahc..h.+h.N................p........l.t....h......p...t..s...ls..L.....c...................-tYc.thht.l..tu..l.p.....h.....pc.......................................................................................................................................................................................................................................	0	102	128	177
+2798	PF02447	GntP_permease		GntP family permease	Bateman A	anon	Pfam-B_1928 (release 5.4)	Family	This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU Swiss:P46858 a low affinity transporter [1] and GntT Swiss:P39835 a high affinity transporter [2].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.44	0.70	-6.00	12	5095	2012-10-02 15:12:49	2003-04-07 12:59:11	11	8	2135	0	706	3333	363	403.30	34	98.00	CHANGED	hsLlhlslu.lllLLlLll+hKlpsFlALllVuhhVGlstGMslscllpohpsGhGGTLGplAlllGLGsMLG+lls-oGuAp+IAhThlppFGcc+lpaAlllsuallGlslFaEVGhlLLlPllFslA+puplsllhlulPhsAuLsssHuhlPPHPGPhslAshhsADlGtslLYGlllu.lPssll...AGPLasK...ahpphh..t.p.....st.hstchhpcpchPuFGlSlhshllPllLMhhpTlsplhhscssshhs.....hhpFlGsPssAhhIAlLlAhaThGhtRGhshpplhchhspulsshAhlLLIIGuGGuFKQVLl-SGVGchluphhpshslSPllhAWllAAllRluhGSATVAslTsuGlls.....Pllsths...sss.tLlsLAsGuGSllhSHVNDuuFWlhKcYhslo.lpETh+TWTlhpTIlSlsGLlhsl.Lhull	................................................................h..llhh.hlu...lhl...ll.l..Ll..h.+....hK......h.....p.s..Fl...u.L..l...l....s...uh.h...s............u............l............h...t............G........h.........s......h...........s.........c.............l............l.........p...........s.........h...p......s.......G....h....G..u...T...L.Gtl...u...l....l....lu.hGshlG+l...ltcoGuAppIApollpph....Gc.......+.......+.......st....h..A.......l.........s.....l..s....u.h..l...l.......G.l....s..........lF...........a..-....V.u.h.V..l....Lh..Pls.h.s....lA.+......p.......s.......t.......h................s.......h.l.hl..ulP.h.s.uu..l.s.s...s..H..s.h.l....PP.p.......Pu..P..h...s..h....A...s..h...........h.......t..A..s.....l.....G...h......s..l....l.....h..G....l......l..lu....lP...ss...l...l...........A...G....la.s+......................h..h..t.p......h.......................................t.....h.s....t....t....h.......h...s...p....p........p.h.............P....u.....h....u.........h.......o...l.......h...s.....h.l..l..P.l....l........L..h.h.......h.....p.s....l...u..p.....h.........h.....h.....s........t.......s.....p..s...h.ht............................hh..p..F.....lG....s.....P.....h..h.......A....h..h.......Ius..l.l.Ah.a.s.hG..h....t........p..s..h........s.h....p.p.....l.............c...............h....hsp.....u....l.t..s.h.u.h....l.l...L....l..l..G..uGGsFtplLh...-....SG...luphl....up....h...h.............p..............t.............h....s.............l..s....s....l...lhuallAs.....llRlA.GS....A....T....V.A...h....h.T.A.u...Gllu.............P.h.l...st..h.s........sls.s...t..lh..s..l.A..h.u....uGS.l.h.hSHV.N.D..u.G.F.W...l..h.p.....c.a..hsho.lt-TlKoW...ohhp....Tlluls.G.hlhsh.llsh.h.....................................................................................................................................................................................................................	0	172	385	568
+2799	PF00392	GntR	gntR; 	Bacterial regulatory proteins, gntR family	Finn RD, Bateman A, Hoskisson PA	anon	Prosite & Pfam-B_6405 (Release 8.0)	Family	This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR [1-2][4][5]. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships [3]. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor [5].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.87	0.72	-4.53	26	49014	2012-10-04 14:01:12	2003-04-07 12:59:11	16	87	4089	55	10949	36460	2838	63.00	29	23.05	CHANGED	hhpplhppLcppIhpGphpsGspLPsEccLuspauVoRsslREALppLtscGllptppspGshV	..........................h..tplhppl.cp.t.I....h....p..G....p....h....t..s.G...s....p...L....P...s.-cp...L..u.p...p...h......s.V.S...RsolRcAlppLt.pc.G..l..l.pt...p...p..s..p..GshV..................	0	2975	6426	8851
+2800	PF02188	GoLoco		GoLoco motif	SMART	anon	Alignment kindly provided by SMART	Motif	\N	20.70	20.70	21.00	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.27	0.72	-6.70	0.72	-4.52	46	1105	2009-09-10 20:12:23	2003-04-07 12:59:11	12	99	91	10	542	983	0	22.80	44	8.24	CHANGED	s-cFa-Lls+sQ.upRhDDQRspl	......-cFF-Llt+sQ.usRhDDQRss...	0	104	151	308
+2801	PF04178	Got1		Got1/Sft2-like family 	Wood V, Finn RD, Fenech M	anon	Pfam-B_7371 (release 7.3) & Pfam-B_8991 (release 14.0)	Family	Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae.  Got1 is thought to facilitate Sed5-dependent fusion events [1].  This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein (Swiss:P38166) [2]. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments [1].	21.80	21.80	24.00	23.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.57	0.71	-3.99	103	970	2009-01-15 18:05:59	2003-04-07 12:59:11	7	13	313	0	645	936	31	114.90	25	66.90	CHANGED	thGlhhhhlu.hhhhhslhh...pshhFuhhaolGslhhlh............uhshLhGspp..thc.hhhppp.Rhhu..ThsahsulhloLh.....huhhhcshhLsllF...ulhp..........h...........ssllhahl..ShhP.hGt.....sslphhhsh	...................................................hGhhhhhh.u.h.hhhhshhh........hhsp.h.hhholGNllhls.......................uh.s.hlhGstpphp.hh.h...p..pp..+...lhu.....Thhahsulhl.sLh...............huh....h....l...c.....s.....hslsllF.........shh...........................hslhh.ahh..uh.P.hGp.....shlp.h...h..............................................................	0	220	359	523
+2802	PF00516	GP120		Envelope glycoprotein GP120	Finn RD	anon	Pfam-B_44 (release 1.0)	Family	The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.	19.90	18.00	19.90	18.00	19.80	17.90	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-13.00	0.70	-6.27	24	146453	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	446	117	0	119635	0	228.30	54	78.04	CHANGED	LWVTVaYGVPVWK-AossLFCAo-s+.......slWATpsClPosPssQElsLssVTEsFshWc..NshVEQhpEDIhSLaDQSLKPCVKLTPLCVohNCschpt.................sssTsss.......................sttthtctEh+NCoFNhTs.hRDKpcphhshFYphDlVshssss............tophhlIpCNTSVITpACsKs.a-sI.l+YCAPAGFAlLKCNDccasGpuP.CoNVSsVpCT+tIcssVSTtLLLNGShAEpcshIh.scshs......sNsphIllphphslsIsCpRPsNpThh.thhhu...GpsFaohtplhs....lRQAaCphst.pWspslppVtppLtcp.p.p......psIsFs.psu........................GGDPElsha.FNCtGEFFYCNsotlhN........W.psp............ssps.......pphhlPCRI+QIINhWpcVGKshYAPPhcG...pIpCsSslTGLllsh..Dusssss.......pThhssuu-h+-.WRuELh+YKlVcIpPlGlAPT+sKR+slt...REKR	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................E..t..c..l..........h.I.R...Sc.N.h.o.........s..Ns.K.sI.IV..p..L..s..c..s..V..p...Is.C.T..R...P.s.N......N.TR...+......u...l....p.....lG....PG..p..u.F...Y......u....T......G......c...I....IG.....DIR.Q..A.H.C.N...l...St..sp.....W.N.p...T.L.p....pl.s.p..KL.p.cpFtp..............p..sI.....Fp...s.u.........................GGD.....El.h..h..h.....h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+2804	PF03010	GP4		GP4	Griffiths-Jones SR	anon	Pfam-B_1094 (release 6.4)	Family	GP4 is a minor membrane-associated glycoproteins. This family contains envelope protein GP4 from equine arteritis virus.	20.10	20.10	22.70	38.10	17.90	16.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.23	0.71	-4.61	3	72	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	2	0	0	68	0	139.50	93	100.00	CHANGED	MKTYGCIFGLLLFAGLPCCWCTFYPCHAAEARNFTYISHGLGHVHGHcGCRNFINVTHSAFLFLNPTTLTAPAITHCLLLVLAAKMEHPNATIWLQLQPFGYHVAGDVTVNLEENKRHPYFKLLRAPALPLGFVAIVYVLLRLVRWAQQCYL	MKhYGCILGLLLFVGLPCCWCTFYPCHAAEARNFTYlSHGlGHVHGHcGCRNFINVTHSAFLFLNPToLTAPAITHCLLLVLAAKMEHPNATIWLQLQPFGYHVAGDVoVNLE.NKRHPYFKLLRAPAhPLGFVAIVYVLLRLVRWAQQCYL	2	0	0	0
+2805	PF00517	GP41		Retroviral envelope protein	Finn RD, Bateman A	anon	Pfam-B_44 (release 1.0)	Family	This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).	25.10	25.10	25.10	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.54	0.71	-4.76	23	40495	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	166	141	21	37279	0	171.40	74	29.32	CHANGED	huAsALshosQs+pllushhppppplhsslpt.pclLphplhslcp.l..LpsRVpulE+alcsptphs.hGCs.+p..hC+TshPh....hN.o.....Ws..NhThpp..Wpcplp.lppplhpllt-spppptpsh.shppLss..ht.hhs...WhshssWl............shIphslhlllhllsLpllhtllps.hh..phh.GYpsl.............ph.lhcspp.spst	................................MGAAS.lT.LTVQARp.LL.SG...I...VQQQ.sN.LLRAI.E.A.QQHLLQLTVWGIKQ....LQ.ARVLAV.ER.YLKDQQLLGIWGCSGKL.....ICT.Ts...VPW..NsS.....W....S.....NKSh.............spIW.s......NMTWMp......W-..+.EIsNYTshIYsL..lE-.SQ.s.QQ..E.KN.Ep..-.LLt.LDK..WAsLWN....WFs.Io.pWL............WYI+IF.IhI..V.uGllu.LRIlhh.llph.ls....+lR...p..GYpPl.................ph..................................................................................	0	12	12	12
+2806	PF02925	gpD		Bacteriophage scaffolding protein D	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	41.10	41.00	18.70	17.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.66	0.71	-4.40	2	78	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	54	10	0	51	2296	139.30	87	92.82	CHANGED	.sh.psVpatTulAul+hlQASAVLDlTE-DFDFLTusKlWIATDRsRARRCVEACVYGTLDFVGYPRFPAPVEFIAAVIAYYVHPVNlQTACLlMEGAEFoENIINGVERPVpAAELFAaTLRl+AG.p-slhDAEENsR	.....sEpuVpFQTAlASIKLIQASAVLDLTEDDFDFLTusKVWIATDRSRARRCVEACVYGTLDFVGYPRFPAPVEFIAAVIAYYVHPVNIQTACLIMEGAEFTENIINGVERPVKAAELFAFTLRVRAGNpDllscAEENlR	0	0	0	0
+2807	PF00044	Gp_dh_N	gpdh; 	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.99	0.71	-4.25	112	14213	2012-10-10 17:06:42	2003-04-07 12:59:11	19	19	8352	412	2317	10425	3516	130.00	46	43.38	CHANGED	l+luINGFGRIGRhVhRshh.....tp.scl-l.VAI...NDhs.sscthAaLhK.....YDSsHG+a.sspVp..hp........sst..lhl.sGc...p.Ip.lhsc+-.PtplPW.tphulD..lVlEuTGhF...psp-pup.t.....Hlp..u.GAKKVllSAP..u+st.......ssohVhGVN.ccpassp..pllSNASC	............................plulNGF.GRIG.R.shRth.............tt....tt..lc..l..VAl................N...D.....h..............s.......sp..h.h...Aa...h.l+.....YDo....sH.Gp.F.......p.......s.......p......Vp....hp......................psp......lhV...sG.c..........t.Ip....lht....c........+...s....P.t...p.....lsW...t......................p..hGs-..hVlEsTG.h.F........ssp....-...cAp.t...........Hlc........u...G..AK.....KVl.I...SAP....uts..........sshhVhGVN.c-.ph...c..s...s.....pllS.NASC..................................................................................................	0	709	1371	1873
+2808	PF02800	Gp_dh_C	gpdh_C; 	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.81	0.71	-4.77	71	15479	2012-10-02 22:00:43	2003-04-07 12:59:11	15	25	9082	412	2355	11397	3548	142.80	53	50.30	CHANGED	LAPlsKVlp.-pFGItcGhMTTlHuhTusQphlDss....+DhRcuRuAA...NIIPoSTGAAKAVuhVlPcLp.GKLsGhAhRVPTssVSllDLssplcKs.soh-ElssAlKcAuc.......s.hcGlLuYo--.lVSoDahusst..SSlaDuptohsls.....sphVKlluWY	.............................................LAPlAK..V.l.p.Dp...F.G...I.hc...GL...M..TT.......l.H.....uh..T......u.s..Q..ps.lD...u...Pp......K...D.....h.Rt...........u...RuAu............tNI.IP...oSTG..AA...KAVG.c.VlPpL.s....G.........K.L.s.G..........hAh.R.......VPTssVSl.V....D.L..os.p.L.c......K.s........s....o........h....-.....-lpts.l.....K......pAup.................................s.h.+.G.lLuY.T....-....-...l.VS..sDa...usst....oSlh.Du..tt.shshs......tphlKlhuWY.............................................	0	719	1391	1898
+2809	PF05024	Gpi1		N-acetylglucosaminyl transferase component (Gpi1)	Moxon SJ	anon	Pfam-B_4796 (release 7.6)	Family	Glycosylphosphatidylinositol (GPI) represents an important anchoring  molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to  phosphatidylinositol (PI). This chemically simple step is genetically  complex because three or four genes are required in both yeast  (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively [1].	20.80	20.80	22.40	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-4.63	7	347	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	276	0	237	333	2	167.60	35	30.43	CHANGED	phhsplh.lhlDlshGlhlh.hLh...Nhphlsshhhphst.ashcpLpohlthLhssPhGlKLNsplsphluphhlahIclW.oahshhpshl.......hlhhhluh.u.hhGhohhluhlhDhlslhohHlhshYhhss+LhshplpslsuLapLFRGKKhNlLRpRlDoh.YshcQlhLGTlLFolLlFLhPTh	................................................t..hs.hh.lh.DlhlGhhlh.hlh............tpht.l..st...h...t..h..h.p......................hhhctLpphlpW.L.h..u.h.PA..GLKLNppLsthLGchFLahIp.h.W.t.s.h...l..t..h..hp..s.hl..................................hll.h.h....l.u.h.u.....hhG.hoh.l.ulh.Dllsl.lT.hHlasaY..hh..su...+laphplphltSLapLFR.GKKhNl..LR.p.R.lD.........o........p........s.........Ys.........lD.........QLhlGTlLFTlLhFLhPTs...............................	1	82	132	199
+2810	PF04113	Gpi16		Gpi16 subunit, GPI transamidase component	Wood V, Finn RD	anon	Pfam-B_7012 (release 7.3);	Family	GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex.  Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase  that adds glycosylphosphatidylinositols (GPIs) to newly  synthesised proteins.  Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small  C-terminal, cytosolic extension with an ER retrieval motif [1].	20.20	20.20	21.40	20.80	17.60	18.40	hmmbuild  -o /dev/null HMM SEED	564	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.93	0.70	-6.50	11	458	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	272	0	326	480	1	374.60	25	89.91	CHANGED	L.Lhshlhlsssssu.s.st........sYcEsLhL+PLPpspLLASFpFcu............ssstssapppcachFPRuLuQILp+uss+ELHLRFopGRWDsEsWG.spPasGhppGGTGVElWAWl-usscpt....................Acc+WhsLTpuLSGLFCASLNFI.DSocTTcPshoFp.sustss.....tp..sh+LhaGsLPtEsVCTENLTPFLKLLPCKGKAGIuoLLD.GHKlFDusWQSMuIDVpslCsss.sp.Chlpl-QoVDhVlDl-RoKR.+.......s.sspph.C-pSKsYpsc.hCaPhtpssptsWSLs-lFGRslpGsCsLuc...tpssVsLpV........................P.phpVhsp.thht......pssstspsaslpsss......saDlhlPt....p.o....phssh-pPslpApRolsGaGQ-RGGlphhhsNPSsp.............sl-FIYhEpLPWFlRhYlHTlpspls.......tpttsssshlcclaY+PulDRc.+uTpLElphslPst.STlsLTY-FEKulLRYsEYPPDANRGFslssAVIolhs.s.........................pssshplRTouLLlsLPTPDFSMPYNVIIhTSTllALAFGulFNlLsRRalstEcutshptpshhs+Ltt+lht....+l+	....................................................................................................................................................................................................................h..................................................................................................................................................................s.G.at...au.........................................................Gh.h.......s.h.................................tta..l.t.hsuhhssuht.h.............................h..........................................hhhu.LstE.hC.T.ENLTPhhcLLPst....stsGlssLhp.....pl.a.ps..apo.t.l..h...p.........t..................h...hp......h..h............................................................................h.h.that.....h......t.....s..s..........l.h.....................................................................................................................................h..h.................hph.h....................................s........h.stp...h.G.u.p.pGth....h.s..t..................................h.hhhhp.lPWahp.ahpoh.ph...t...............................................h.h....s....u.p..+......tst....hch.h...lPst.ps...............h...ht......hphc+..hLphtEasPDss+Ga.l.s.ul....l..h...........................................................................h..hhopslLl.LssPDFSMPYNVIhhssThhulhaG.hhshhh.+.h......................................................htth.............................................................	0	116	207	282
+2811	PF02831	gpW		gpW	Bateman A	anon	[1]	Family	gpW is a 68 residue protein known to be present in  phage particles. Extracts of phage-infected cells lacking gpW contain DNA-filled heads, and active tails, but no infectious virions. gpW is required for the addition of gpFII to the head, which is, in turn, required for the attachment of tails. Since gpFII and tails are known to be attached at the connector, gpW is also likely to assemble at this site. The addition of gpW to filled heads increases the DNase resistance of the packaged DNA, suggesting that gpW either forms a plug at the connector to prevent ejection of the DNA, or binds directly to the DNA. The large number of positively charged residues in gpW (its calculated pI is 10.8) is consistent with a role in DNA interaction [1].	20.90	20.90	20.90	21.30	20.70	18.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.38	0.72	-4.42	5	521	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	332	3	23	146	0	67.40	62	95.68	CHANGED	MTcpp...ELQpARsAhHDLhTGKRVVS...VQKDG.RRVEYTAoSluDL++YIs-LEuQLGhot.RRRuPlGVRl	.............Msp.t....ELt....AhRtAhhDLhTG.KRV.so.....VQKDG.RRlEaTAsSls-Lp+hI...s-hEs.l..G...h....Tp..RRRtPhGhhl...................	0	3	10	18
+2812	PF04965	GPW_gp25		Gene 25-like lysozyme	Bateman A	anon	COG3628	Domain	This family includes the phage protein Gene 25 from T4 which is a structural component of the outer wedge of the baseplate that has acidic lysozyme activity [1]. The family also includes relatives from bacteria that are also presumably lysozymes.	25.30	25.30	25.40	25.30	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.18	0.72	-4.46	181	3115	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1505	1	550	1824	1365	100.80	22	74.20	CHANGED	sshss...htp.slp.......pslptlLsTphGpph..............................h.saG..ls-lhstsh..ssssttplpptlppultpa.EPRlp.hhpV..plts........................tspl.phplpup..lh.p...t.t..ls	.....................phhcplp.......pslpplLsT..usph..................................th.saG....ls.c.hh..sts.....stshttplpptlppAlh.......+........a...EPRlp.hhpVplp........tp.............sspl.shplpuhlh.p........hhh..............................	0	111	282	426
+2813	PF05084	GRA6		Granule antigen protein (GRA6)	Moxon SJ	anon	Pfam-B_6204 (release 7.7)	Family	This family contains the granule antigen protein GRA6 which is found in the parasitic protozoa Toxoplasma gondii and Neospora caninum. GRA6 protein plays an important role in the antigenicity and pathogenicity in these organisms [1].	22.10	22.10	22.10	132.00	20.40	22.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.48	0.70	-4.81	2	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	4	0	3	51	0	183.70	91	94.90	CHANGED	MApsthhhRp+RsFsPlTVshlAVshVsFMGV.lsShGusssAssstuVcts.pthsS.Gt...AVGToE-YVNSSthuGupscu.AEs-pputtsEsDVpP.sVh..spEttu.ups.s.pERhEEtsst.+.ssVpps.spssuKRpQtRHRlIGssVlAssVAhLhhhF.RRpu...........GusctG..............GcsEsGuE-	.MAHGGIHLRQKRNFCPLTVSTVAVVFVVFMGVLVNSLGGVAVAADSGGVKQTPSETGSSGGQQEAVGTTEDYVNSSAMGGGQGDSLAEDDTT.SDAAEGDVDPFPVL..ANEGKSEARGPSLEERIEEQGTRRRYSSVQEPQAKVPSKRTQKRHRLIGAVVLAVSVAMLTAFFLRRTGRRSP.EPSGssGGNDAGNNAGNGGNEGRG.tGcs-.........	0	2	2	3
+2814	PF00267	Porin_1	Gram-ve_porins; 	Gram-negative porin	Finn RD	anon	Prosite	Domain	\N	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.16	0.70	-5.17	18	5868	2012-10-03 17:14:36	2003-04-07 12:59:11	16	2	765	89	237	5994	230	301.00	39	93.43	CHANGED	KsGNK...........LDLYGKssGhHhaos.csus-.....GDpoYuRIGFKGETQIsDpLTGaGQWEYsspusssEup.ssp..ttTRLuFAGLKaG-aGShDYGRNYGVlYDlpuaTDhhPEFGGDoh...stsDsaMpsRusGlAT.YRNsDFFGLVDGLsFALQYQGKNtp...............scshh......+pNGD........GaGhShoY-hu..shuhuuAYssScRos-Qt.t.............p..utG-+A-sassGuKYDANNlYLAshYupTpNhT.hu.............shuhANKsQNhEVsAQYQF.DFG.LRPuluYlpSKGKDlsu.........ths-pDLVKYVsVGATYYFNKNMSsaVDYKINhLDcss.h..t.GlsoDDhsAVGLVYQF	........................................................................KsGsc...........hshh.....s.....ch.s.u......h..+....h.....h..os.....pp...u...p...c.........hs.p.h.h..s+.l.GFKGpp..p..l.s..s.t.........Lpu.h.................h....QhE.......p.......h.......p...........s......s............s.......s........-..........................................t...............s...........t..................ts.....R.u.........FsGLK..u-.aG.ohchGR......s...h......u......l.......l.......h......D.......s.....t......s....h..........s.......D............................P....................u...G.csh......................hts.s...s...a.....h.....p......t..............c....s.....p.....s..l...........u...........s.........Yc....s.....s......-......F...h...G....l....s.......s......u......l..p..a..A....h..p.......p....u.p.st...........................................................t...t..hh..............+.p.N..G.D......................u..a..t...s...u...h..s.Y...c.......s......G..................h...h....sh..u........u..u....Y...s..p..p..s...c...s...s.c...p................................................s....s....s.c..+..t.p.....s.a..p...h..s....h....t...Y.......D...s...N...s...l.....Y......l..A..s..t.......u..p...p...p..s.h..p...hs...................................shs..s...K..s...p....s.......h.....E...l....s...A......p....h.......p....a........c.....F.......G....l......p....P.......p....l.......u......Y....h...p.....u.h...s...t.s......lps......................hs-.p..s..h.h...c.......l..s..V......G..A.pY...F...sK..p.....h..S.....s..h.....V.....s...h.......t.....h...............h.....s.......p...sp............................h.....s.....s...........s......h.....s.....u..l..GhhapF.........................................................................................................................................................................................................................................................	0	18	57	141
+2815	PF00746	Gram_pos_anchor		Gram positive anchor	Bateman A	anon	Pfam-B_457 (release 2.1)	Family	\N	20.50	17.00	20.50	17.10	20.40	16.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.04	0.72	-4.03	84	9438	2012-10-02 15:23:12	2003-04-07 12:59:11	16	692	1185	11	443	6888	16	38.70	27	4.73	CHANGED	spssptppLPpTG..pssshhhshhGh.hhhssuullhht++	...........t..tpptppLPpTG....ppss.s...hh..s..l..hGh..l.hhhhusllhh++.............	0	110	196	316
+2816	PF01271	Granin		Granin (chromogranin or secretogranin)	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	27.70	26.30	23.80	24.90	hmmbuild  --amino -o /dev/null HMM SEED	586	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-13.02	0.70	-5.80	9	290	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	53	2	101	264	0	329.00	22	89.82	CHANGED	ts+s-p.Vh+CllEVlSssLsKsSPsPlo.EChEsLcpsccclpspEpppN.ssh.tl+hLpD.A-stt....stpt.su.s.....ph.h.s.....tEsGu+sREpps.........s...tcph...h..c..tpp..ccp.c.hph...h.-ttpccph.ctssElsEsh.s.pspAohccshpElu+h-s.sp.p.RE+scccpKs.p-ss--sh+spshPtEs.ssspstss.............pEuEEspspE.s+c..+.psc+scShsscpp.uGphsh--E.............................s..cptphspcp+shSuh..........hhspG+pppptptccuccp.tcth-cps..p-ls.osshps..p-t.+tlc..sGcp.ttts-sstchps.tsh--cscs-.sHsph.cs...tc-th.s+tPps.......phLshG-ph...G.....th...p......c.ppEEsh..................h.LpppahD.tpWpppcpp++t.hs-phLE..tEEcs-hshsM+spFPEh..s.............uYtKR....sPt.sL+RtactsupEDuLctaht.ts...sct.uEEp+c...ts.pE-soAN+...ht-EDpELEsLuAl-tELpKlA+capshRRG	...............................................................h.ph...ht.t..p..s.s...cshphlc..tpp....h.....p..p...t.s.............hp...p........t......t..t......................................................................................................................................................................................................t.............t.................................................t...t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	11	33
+2817	PF00396	Granulin	granulin; 	Granulin	Finn RD	anon	Prosite	Family	\N	20.90	20.90	22.50	21.20	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.76	0.72	-3.86	94	1181	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	140	9	509	1067	2	43.50	48	31.13	CHANGED	TCCphss.Gs....WuCCPhspAVCCsDthHCCPpGa....pCshpsspChp	.......................TCCph.s..Gs......WGCCPhs.pAVCCsD+h.HCCPpGa....pCshpt.spCh.....	0	196	261	377
+2818	PF04495	GRASP55_65		GRASP55/65 PDZ-like domain 	Finn RD, Bateman A	anon	Pfam-B_3985 (release 7.5)	Domain	GRASP55 (Golgi re-assembly stacking protein of 55 kDa) and GRASP65 (a 65 kDa) protein are highly homologous. GRASP55 is a component of the Golgi stacking machinery. GRASP65, an N-ethylmaleimide- sensitive membrane protein required for the stacking of Golgi cisternae in a cell-free system [1].  This region appears to be related to the PDZ domain.	27.70	27.70	27.70	27.80	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.86	0.71	-4.19	37	638	2012-10-02 11:12:46	2003-04-07 12:59:11	9	5	271	6	397	620	5	118.60	38	48.11	CHANGED	hpVassKstphRplpl.sP...............Sshass..................uLLGlolcasshp.ss-plWHVL-V..ssSPAthAG.LhPaoDYIlGss..........sllp..............................spcslhsLlEs+.s+.............................sLpLaVYNo-pDssREVslsPspsWGG-...GuLGCslGYGhLHRIPsh	......................................................................................................................................Ghthp.t....sspp.s..aHVLcV.p.ssSPAthAG.LcP.ahDaI...l...u.h.st......................shLp..............................-.s.-....s.L..hs...Ll..c.s.p..s+..............................Pl+LhV..Y..Ns...c..s...p.ss.R.E..V..plsPs.ptWGGp............G.LGs.l..................................................................................................	0	138	198	303
+2819	PF04723	GRDA		Glycine reductase complex selenoprotein A	Kerrison ND	anon	DOMO:DM04874;	Family	Found in clostridia, this protein contains one active site selenocysteine and catalyses the reductive deamination of glycine, which is coupled to the esterification of orthophosphate resulting in the formation of ATP [1]. A member of this family may also exist in Treponema denticola [2].	21.90	21.90	22.30	23.10	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.72	0.71	-4.50	3	223	2012-10-10 17:06:42	2003-04-07 12:59:11	9	1	110	0	49	188	4	84.70	42	95.03	CHANGED	SlFsGKKVIIIGDRDGIPGPAIEECLKuIssEVlFSSTECFVUTAAGAMDLENQp+VK-ATEpaGAENLVVLlGAAEAESAGLAAETVTAGDPTFAGPLAGVELGLRVYHAVEPEFKuEVDuAIYDDQlGMMEMVLDVDuIIEEMpSIRu	...........................................................................................................................................................................................................	0	22	40	44
+2820	PF01272	GreA_GreB		Transcription elongation factor, GreA/GreB, C-term	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This domain has an FKBP-like fold.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.43	0.72	-4.27	137	7631	2012-10-02 13:30:10	2003-04-07 12:59:11	14	15	4301	28	1688	4424	1946	77.30	33	45.59	CHANGED	hss.....spVthGupVsl..ps...ssspppsaplVGs..........pEuch...pps..pIShpSPlupALlG+c.hGDplplpsPsG.php.hcIlplph	...................................t..p.spVhhGupVpl....ts.....ss...s...-...c..p..papI.VGs...................................sE.ucs.........pps.......tIShpSPlu+ALlGKc.hGD....p....l.p.l.ps.PsG..p....hp..hcllplp..................	0	512	1024	1380
+2821	PF03449	GreA_GreB_N		Transcription elongation factor, N-terminal	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This domain adopts a long alpha-hairpin structure.	21.80	21.80	21.80	22.00	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.29	0.72	-3.92	134	5904	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	4289	22	1237	3294	1838	74.30	42	42.85	CHANGED	hp.....tp.h.lTtcGhc+LcpELcpLtpscRPclsctlspARspGDLuENAEYcAAKccQshl-uRIppLpppLsp.A.pl	.....................p..h.hThcGhc+.LcpELcpLcpscRPclsptIstA.RuhG.DLSENAEYcAAK-cQuh..lEu.RIppL-ptLpsApl........	0	399	789	1035
+2822	PF01184	Grp1_Fun34_YaaH		GPR1/FUN34/yaaH family	Finn RD, Bateman A, Wood V, Studholme DJ	anon	Prosite	Family	The Ady2 protein in (Swiss:P25613) is required for acetate in Saccharomyces cerevisiae, and is probably an acetate transporter. A homologue in Yarrowia lipolytica (GPR1) has a role in acetic acid sensitivity.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.36	0.70	-5.04	58	1687	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	1218	0	658	1121	22	193.00	37	86.80	CHANGED	FG...Gshs....PG.........htP.sp+phANPAPLGLsuFulTTFlLuhaNspshGlssPNllVuhAhFYGGlsQhlAGlWEhthGN...TFGuTAhoSYGuFWlSauslhls..sFGIhsAYtst.t...........hssAlGhaLluWsIFThhhhlsTlKSTluFhhlFhhLslsFlLLAsuph.......osstsltpAGGhhGllsAhhAaYsAhAGlAsppNSa..hh..sh.lPhsp...pt	..............................hs.............................p+hA.N..PuPLGLhGF..uh..TTll..L.s.laN..s.....Gh........h..s..l.....s...u.......l..l..l........u...hu...l.FYGG.luQlhAGlhEa++G.N.......TFGhTAFoSY.....Gu...........FWLoh.s..s..l.l...l.....h....phGls...su..............................................s..ph.l.G..hY......Lhh....W.u.....lFTh..h.M.hh...u..T...L+.s............sh.sl...h.lFh.sLslhFhLL..Alush........................................s.u.s...t.s.l.hp...h.AG..ahG..llsuhsAh..YhAhutllN.pphup.........h......tt............................................	2	200	379	560
+2823	PF01025	GrpE		GrpE	Bateman A	anon	Pfam-B_817 (release 3.0)	Family	\N	25.80	25.80	26.60	26.00	25.40	25.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.97	0.71	-4.70	111	5353	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	4825	8	1413	3716	2850	180.10	28	89.19	CHANGED	pp.............ttttpsphpshppp............lpp............................hcp.......chc.....ch..pcphh..........RthA-h-.Nh++Rh..p+-hp.phpcauhpphhpc...LLsllD...sl-+Alph...........pspphp.......slhcG..lchshcphhphL.pchGlptlss.h.GctFDPphH-..Altph........tssp.hts.ssllplhppGYplp.-R...llRsAhVhVup	..............................................................................................................t.tttptpppt........tttt.tt..ppc........................ltp........................................h.pt................ph.p...............-h....c-chL.....................R..hp..AE.h-..N.......h...+.......+Rs........pc-hp.......psp...c..a..u....hpch.s.p....-.......l.L.PllD...........sL-RA.lps...............tstphp..............................................sl.hcG...lch..shcpl.hpsl.cc..h.Glctlss.......t...G......p..t..FDPshHp...Altp..h...........ss..sc....hts....ssl.spVhQ+GY..p..Lp..-.R.....llRPAhVsVu.................................	0	485	928	1199
+2824	PF02955	GSH-S_ATP		Prokaryotic glutathione synthetase, ATP-grasp domain	Griffiths-Jones SR, Bateman A	anon	Structural domain	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-5.13	37	1779	2012-10-10 13:17:03	2003-04-07 12:59:11	11	6	1678	4	426	2863	2533	171.60	52	54.80	CHANGED	EKLa.stpFs....chh.PsTLVopchpcl+pFhpcpsD..lILKPLsGhGGpulFRlpps.DsNlssllEhhTptsp..p.lMsQpalP-lpcGDKRIlllsG-Pls......ulsRlPt.tGEhRuNlAsGGpucsppLoc+-hcIsppluPpL+c+GLhFVGlDVIGshLTEINVTSPTGlpEIcphts	.....................................................EKLa.ss.Fs....-l.s.P.T.LV.T..R...s....t.s...p..l..+s....Fhp....c.....H......u..D.....lI...LKPL..D....G...M..G..G..uu..I..FRlcp..........s.....D................s.............N..........L....u..........s.....I........l...E...o....L...T.....p...t......G..p...............c..h..sM...AQpY......L....P....s..I...c..c.....G....DK....Rl..LlV...DGE.P..VP................YsLA.R.....I....P....p.....s..G..E...s...R......G.....N.L...A...A..G...GRG......E...s...p..s..Lo...-....p.Dhc....I.Ac.p.l..G.P...s..L.+.c+.G.LlFVG...LD..l..I.....G.D.....h.....L..T.EIN..VT.SPT..ClREI-t..t....................................................................................................................	0	103	240	337
+2825	PF02951	GSH-S_N	GTS_N; 	Prokaryotic glutathione synthetase, N-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.30	21.30	21.60	21.70	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.54	0.71	-4.30	155	1672	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1622	4	395	1136	1521	119.20	46	37.80	CHANGED	l+luhlMDPlpslslt+DSoaAhhhEAQpRGHplaahpsscLth.c.....sG..........cshApspsl.plppsts..........saa...phuptp.phsLuc.hDllLMRpDPPFDhpYlhATalLEps.....pp....tusLVlNcPpulR	..............lKlullMDPIusINI.cKDSoFAMhLEAQ+RGa-LaYh-.sDLhl..p......sG.................csp.Ac.s.+sl....pVc....pshs...........cWa.....ph.s..s....cp....clsL.u-.lDVILMRKDPPFDh...E......a.I..Y.A.T.YlL..E+.A....Ec.....pGsLlVN+PQSLR....................................	0	89	217	308
+2826	PF03917	GSH_synth_ATP		Eukaryotic glutathione synthase, ATP binding domain	Mifsud W, Griffiths-Jones SR, Finn RD	anon	Pfam-B_2922 (release 6.5)	Domain	\N	25.00	25.00	25.50	25.20	24.00	24.00	hmmbuild  -o /dev/null --hand HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.16	0.70	-5.87	10	535	2009-01-15 18:05:59	2003-04-07 12:59:11	12	14	352	15	323	538	43	395.70	31	92.73	CHANGED	h-hcphDpchLpcLshDAlsWAhLpGLlhs-+osp+SGsVsuV.lsauPlsLLPoshPcutacQAsplpPlFNELVDRVS.DusFLppoLS+TpKs.....D-FTuRLl-IHpKh......Lcp..NKKp-lRLGlaRSDYMlD...-pTpu....LhQIEhNTISsSFuGlushlopLHpplLpphsc...thul-upplPsNsulpthA-ALAKAWscY...............ssPcAlllhVVQsEERNhaDQ+hlsupL+c+atlsshR+slAEl-ptuclpsD..........hsLhlsGQtVAVVYFRuGYoPsDYPSEpEWcARLLlEpSpAlKCPsIuhHLsGTKKIQQELA+PGVLERFL-sK.--lA+LRcsFAGLWSLDDo.....-lV+pAlEcPEhFVhKPQREGGGNNlYG--l+psLh+Lpc..oEEcAAYILMp+IhPpss.pshLlR.sGhhcpscsISELGIaGsYLRN..+DcVlhNppSGaLlRTKssoSsEGGVAAGFAVLDSlYL	..........................................................................................................................................................hh.thh.hsh.pGhhhh......................................................sPh..oLh..Po.hPcthappuh.t.lp.haNpLh.s.t.lu......p..s...t.aL.tp.hl.......p.p...hh...ps......................D.p.Fsu.p.Lhplatph.................................hpp......sh.h..p.t..l...............LG..lhRSDYMhc.......tts...t.................................l+QlEhNTIusS.Fuu.lu.shsstlHph.lhp.....h..h................................p............t.......p.l.s.t..N..p.s.htt.l...utulstA..hp..ass.pss.hhhh....h.h.ppth.t.th......hhhhth......t.................................................................................th...t.thsshhatsshhstph.spttWpsRhhlEpStAlKCPsl.hpLsGoKKl.QQ..L........u......p.......s................s.............h....L..p..pF..l.......................s................t......p....p..h.tp.........lcps..F......ss.has.....L..-...............s.......................s................p......h..................h....t.....Ah......p..p..P..p...paVLKPQR.EGG..GNNlYtpp..l.phLp.p..ltp................pchsu...aILMphI.....P.....ts..hh.l.....R....s.....s..................h............................t.p.h........lSELGlaGs......hlhp................tt...p......l.......lhN.....p.p..sGaLlRTK.t.pssEGGVuuGhuslDo.hL...................................................................................................	0	114	178	269
+2827	PF03199	GSH_synthase		Eukaryotic glutathione synthase	Mifsud W	anon	Pfam-B_2922 (release 6.5)	Domain	\N	20.90	20.90	23.50	21.80	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.42	0.72	-3.94	51	469	2012-10-01 21:12:38	2003-04-07 12:59:11	10	12	345	15	283	471	21	103.90	38	21.70	CHANGED	spslVLhVVQssERNhaDQ+hlEhtLhcct.t.IpolRtThs-lpppsplt...............ss..t.....pL.....hlpu..t-VuVVYaRuGYsPsDY..ss.......-s..pWpARLhlEpSpAIKCPolhtpLu	..............................................s.pssllhlVQtsE.RNhaDQ+hl.....Eh...pLhc.......p........t....t.....lps..l..R......hohs-.lt.pp.s.pls.........................................................ss....p..............pL.....hl.s.s........tEVuVVYaRuGYsPsDY...so.........c.p..pWcARlhlEpSpAlKCPolthpLs.............	0	96	155	234
+2828	PF00255	GSHPx		Glutathione peroxidase	Finn RD	anon	Prosite	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.37	0.72	-4.68	12	4817	2012-10-03 14:45:55	2003-04-07 12:59:11	14	11	3035	33	1412	4342	2461	104.50	45	59.73	CHANGED	hY-asshslsG.p.hshspa+GKVlLIVNVAShsGhTs.pYppLptL.c+htspGLsILGFPCNQFGcQEPupscE....lKhhpsst...atssFslFpKl-VNGpstcPlYpaLK	................................hashp.sps.hpG.pshsL..p.p.Y..c..G..K..V..lL..l..V..N.s.A........S.c.......C...G.h.T............s....QY..p...t...L..............p......pLaccY.....p...c....p...G.........h........h.l...L..G........F..P.......C..N...Q.F.s.........t...Q...E..P.G.....o.scE.....................Ipp..aCphs...........a.G.V.o..F.P.hF.sK...l.-VN...Gp....s.s..c....P..LapaL...........................................................	0	446	800	1119
+2829	PF03738	GSP_synth		Glutathionylspermidine synthase preATP-grasp	Bateman A	anon	COG0754	Family	This region contains the Glutathionylspermidine synthase enzymatic activity EC:6.3.1.8. This is the C-terminal region in bienzymes such as Swiss:P43675. Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design [1]. This region, the pre-ATP grasp region, probably carries the substrate-binding site [2].	22.40	22.40	22.50	22.40	21.40	22.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.42	0.72	-3.73	159	2307	2012-10-01 21:12:38	2003-04-07 12:59:11	9	6	1331	17	262	1223	27	99.70	35	22.57	CHANGED	tl.aFssh....ssshEDttTs..taLpcsAppA.............Ghp.sthls.lc-.lshs.............t..pGth.hDh-s...p.lchlFK.LYPWEhhhc-.......................p...hustl..thtp......sthlEPsWphlhS	...............lahsss..c-shEDcsTs..pYL.p-sAppA.............Ghp...ocalhl--.lGhs....................t...tGph..s.......Dh..-s........plIpslFK.LYPWEahhc-..........................c.......hsshLhtp..t.............sthlEPhWpsIlS................................................	0	56	147	206
+2830	PF00437	T2SE	GSPII_E;	Type II/IV secretion system protein	Finn RD, Bateman A	anon	Prosite & Pfam-B_2215 (Release 8.0)	Family	This family contains both type II and type IV Swiss:P54907 pathway secretion proteins from bacteria. Swiss:P07169 VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection [1]. 	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.85	0.70	-5.50	23	13216	2012-10-05 12:31:08	2003-04-07 12:59:11	15	70	4434	45	3599	12796	4731	263.40	26	60.45	CHANGED	tthhhcsl..ctssoDIhlps.tc.lhl..Rlsu...hlpplhp.stptsttllpRltshuph-IuE++...Ducls.......suhchclsh.Psshu..tp..lslR..cpsstth..sLpcLuhssshp.................................pthtchLcps...+s.ILVoGsTGSGKTThL...AhLstlssp..pcpIlTlEDssElpl.puhsplplps+.......sslThschLRuhLR.cPDhIhlGElRDtEshcl.lpAspTGH.s.loTLHsNSAhuAlpRLpphu........ls.h.lps.ltsl..ls.+LsRph	.....................................................................................................................................................hh......h...p....ts...oDl.h..l.....p....s..............t...........p...hhl.....+hst...............h.h..t..h....................h......s.......p...........h..t....t....l.......h.t....p.....l....t.....h...h.....s.....t.....h..............p.....l.....s.....-......p.........p..................-..u.....p..ht..........................pshch......+.l.s..h....h.s....t.ths...........p............hs...l.R............ph..s...t.t.hh.....sl.p.p..L..s..h......s...............................................................................t.t..h...t.p..h...l...p..p...s..................p.....G.....h.l...L.l..o..GsTGSGKT.T.o.L.......t.u.h..l..s.....h...l.....sps...........tp.......+.I.....l....T....l....E.......D....P...l...E.....h.......h......p........t........h.....p.......p.....l...p..lppc........................ssh...o...a...s...s...s...L+..u.s....L.R....p.c....P..D..l.I....llGE.l..R.D.t.......E..T.h.ch.slp.A.u.p...T...G...H..h..l...h..o..TL...Hs.s...s.utp.s....l.s.R..L..h...s..hs.............ht..........l...p.p...t.l..t..t..s........hs...pl...h...............................................................................................	0	1167	2366	3072
+2831	PF05157	T2SE_Nter	GSPII_E_N;	Type II secretion system (T2SS), protein E, N-terminal domain	Yeats C, Desvaux M	anon	Yeats C	Domain	This domain is found at the N-terminus of members of the Type II secretion system protein E. Proteins in this subfamily are typically involved in Type 4 pilus biogenesis (eg Swiss:Q9X4G8), though some are involved in other processes; for instance aggregation in Myxococcus xanthus (Swiss:Q9RF11) [1]. The structure of this domain is now known [2,3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.07	0.72	-4.01	110	3482	2009-01-15 18:05:59	2003-04-07 12:59:11	10	45	1888	2	1060	2838	803	107.90	18	19.45	CHANGED	Llp........Ghhs..........................................p......pp.............................lhpsLucp.............................hslsh........lshpshphs.p..hhth.....lshshhpctthlPlp..hc.s......splhl..AhscP...hs.hphh-plphh.hth.plp..hhlsspsplp.phlpch....hspptst	.............................................................................................................thls..........................................tpp..........................................lhphlut.............................................................hshsh..................hs.l.p..t..h...t..h..s..t....hhth.........hstphsp+apslP.lp.....tp..s........................sp..lhl...A...hsDP..hs.htsl.-.s.lpht.sst..plc........hslsscpplp.ptlpchht.....p.........................................	1	361	719	946
+2832	PF00482	T2SF	GSPII_F;	Type II secretion system (T2SS), protein F	Finn RD, Yeats C, Desvaux M	anon	Prosite	Domain	The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella [1]. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.29	0.71	-4.21	340	14010	2009-09-11 10:25:30	2003-04-07 12:59:11	18	9	3954	8	3638	10916	2531	123.70	19	56.05	CHANGED	hhcplushlp.uGlslhpulp..hlspptt..........pthhpptlppltpplptGt...sh..s...puhp................phs.....hh.sthhhthlpsu-puGsLsphLpphuphhcpphphp....hchhsshhtPh......hhlhluhhlhhhllshl.ls	..............................................hcpLuhhlp.uGl.slhpulp....hlsppht........................sthhpp.h.l.p.p..l..tp..p.l.....p.p.Gt.......sl.......s......pulp....................................phs......hF..sshh...ht....h.l.t.sG....E....p.....u.G.p.....L..s.....ph...Lp...pluphhcpphphp...........tc...hhts..h..h.Ph...........lllhl.uhhlhh.hllshllP..................................................	0	1183	2343	3069
+2833	PF00263	Secretin	Bac_GSPproteins; GSPII_III; Secretin; Secretin_C; 	Bacterial type II and III secretion system protein	Finn RD	anon	Prosite	Family	\N	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.74	0.71	-4.86	155	5833	2009-01-15 18:05:59	2003-04-07 12:59:11	16	82	2114	0	1392	4693	1363	161.40	27	28.57	CHANGED	ALppsupsclLusPplhshss......ppAplp.lGpplshh....sspss........ssss.........................hp..hp...........................ssGlpLp.lsP........plss.ssp...lpLplp..phoshss..t..............................................sssPs.....lsp.+plsT.plhlcsGpTlllGGllpcppppspspVP....hLu-IP....llGt.LF+spspppp+sELllhlTPcl...lp	..........................................................................................ALpppupspllu.sPp.lhshss.......................ppA.lp.sG..p.p.lPh.h..........ps.............................s.ss.ss.............................lp....hp.................................................................................................................ps..GltLc.V.s.P................pltp...ssp............lpL.p.lp...phus.hsp..stp..........................................................................................stsss....lsp..+plsT.....pVt.l.p.sGp.o.lllGGlhpcp.ppp..shsp....l.P.....hL.GD.IP........llGt....LF+pp.sp..p.pp+ppLllhlpPpll.......................................	0	408	827	1132
+2834	PF01203	T2SN	T2SP_N; GSPII_N;	Type II secretion system (T2SS), protein N	Finn RD, Bateman A, Desvaux M	anon	Prosite	Family	Members of the T2SN family are involved in the Type II protein secretion system. The precise function of these proteins is unknown.	26.00	26.00	26.10	26.60	25.80	25.80	hmmbuild  --amino -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.42	0.70	-4.77	42	400	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	393	0	109	339	61	211.50	25	84.42	CHANGED	hslsps.lslsulsGolWpGpspplphp...sh.pls.pVpWslsshuLltGpsphslphup....tt.slpG.pG.l.shuhu.uhtspslphshssshlhphh....hshPlps....sGplpl.....tlppht.....upshCppl.pGplhhp.suslpsshGsl.sLG.sltusluCp.s.uplhsphppsssplslshpsplp..sstpaphsuplc.sssshPsslppsLshlGps.cs...pGtashphpGRl	..................................t.lplssspGolWpGp.A..s.l.thp...................sh...h.....G..plpWchphh....sLlhGphphclchsp.......tlpu.tuhl....shuh.s..uhhspshthslPuu.hlhshh.........hPh.s.lph..pGplpl..........slpphp.......hups.hspph.pGplhhp..tspl....p....usl....u....s....l....sLG....sltusls...sp..s..uslslpl.....sp...p..s.st...lt.hphphslt....sss..paphpuhhp..s...tsp.s....t...s....Ltt.LshLGps.su...pGt.h.h....................................................................	0	28	57	83
+2835	PF03958	Secretin_N	NolW-like; GSPII_III_N; 	Bacterial type II/III secretion system short domain	Yeats C	anon	Yeats C	Domain	This is a short, often repeated, domain found in bacterial type II/III secretory system proteins.\	\	\	\	\	   All previous NolW-like domains fall into this family.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.50	0.72	-3.80	231	6199	2009-01-15 18:05:59	2003-04-07 12:59:11	12	49	1721	11	1290	4691	1113	81.90	24	21.96	CHANGED	spll.Lphssus-...............lsshLpph.h..................................................................................stph.pltssspsNslllp.ussptlpplpp.llpplDhsttp	..............................................................................................................pll.LpausAp-...................................ls.plLppl.h................................................................................................................................................ss.ps..plssD..pc.oNslllp.ssssshpplpp.lIppLDh..t.....................................	0	370	706	1018
+2836	PF02501	T2SI	GSPII_IJ;	Type II secretion system (T2SS), protein I	Mian N, Bateman A, Desvaux M	anon	Pfam-B_2607 (release 5.4)	Domain	The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. As members of the T2SJ family, members of the T2SI family are pseudopilins containing prepilin signal sequences [1].	25.00	25.00	25.60	25.40	22.90	21.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.50	0.72	-4.01	100	934	2012-10-03 10:38:27	2003-04-07 12:59:11	12	4	817	9	179	576	128	81.20	28	65.20	CHANGED	tLc-+slAtalA-NplsclpLp.pthPshu...tppupsphuGppWhhphp.ltsTsss.p.......hpplclpVt.........spp.pssslspLssalsp	.................Lc-+slAsWlA-Nphspl....pLt...pth.pss.........pppGpsphuGppWaW+pp..shsT...sss.h........lptl-lpVs........ppctsssltphpuhh..................................	0	34	83	132
+2837	PF03934	T2SK	GspK;	Type II secretion system (T2SS), protein K	Bateman A, Desvaux M	anon	COG3156	Family	Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX  and XcpX.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.75	0.70	-5.24	106	1236	2012-10-03 02:11:09	2003-04-07 12:59:11	8	4	993	1	289	1639	405	262.20	26	82.09	CHANGED	c.phphcpspshhttpQAhahuhuupshActlLppsh................hspLsph.WA...ts..h.hsl-.....................p.GplsuplpDhpupFNLNsL...............................stsst.................................hpshshptappLLpsLuls......t.tupplscslhDalDsD............................pt..t..GuE-s.Y..tutsssahs.usp.hssluELphl.Ghosphhp+LtPalssLP......s..pthlNlNTh....sA.lLsAlhss.....lshspAppllpp..........R..sts.sap..sls-ahst............lss.......t.....hpstls...lsSpaFtlpup....sphspsphphpollpps...............s.ssshs.l	......................................................................................t.phtpsps..phtQAhahuhu..u..p.p.hAh.t.h.Lppshpppt.................hspLsp....WA............ts....t....h....ls...................................................................p..up..l..psplpDtpupF.N..LNsL......................................ht..s.....................................pshshphhptLl..t.p....l...s.ls...............thpuctl..spul.h-alDp.D..................................pps...t.hhG.s.EDs.Y.....ut.s.ssahs...usp............htsluE...L+hl.p..Ghs...s..........t.l....h..........p.......+.........L..tPhV....s........s........LP...........sphpl.NlNTh...............pu...lLtAlh.s......lo....s.pA..ptllpp...................R..........stp..sat....s.hsph.htt............................lss............htt............hpshls..l.p.Sp.aF..lpsp....hhh.sp.p.hp.hpoll.t.t.p.....hh...............................................................................................................	0	83	161	229
+2838	PF05134	T2SL	GspL;	Type II secretion system (T2SS), protein L	Moxon SJ, Bateman A, Desvaux M	anon	Pfam-B_6494 (release 7.7)	Family	This family consists of Type II secretion system protein L sequences from several Gram-negative (diderm) bacteria. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. T2SL is predicted to contain a large cytoplasmic domain represented by this family and has been shown to interact with the autophosphorylating cytoplasmic membrane protein T2SE. It is thought that the tri-molecular complex of T2SL, T2SE (Pfam:PF00437) and T2SM (Pfam:PF04612) might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation [1].	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.33	0.70	-5.18	19	962	2012-10-02 23:34:14	2003-04-07 12:59:11	8	5	829	4	181	775	109	221.90	22	57.66	CHANGED	Lhl+Lsssstpshph......hpstttphhtpG....phsstpshspls.hssts.shlllPusslhhpplsLPstst+phhpsLPahLE-plApDl-plHhslh.............stps-.ptpVssVc+phhptWLshhpptGlssppllPDshsLPh..sssuhsshphss..................................................pWLlRpstttGhus-tphhshhhtt...........ltshsssPt.s.s...........htsts.pshhhlhApshht...sshsLhpGtFs.p	.....................................................................t...t..h...W...................tt....htpG.............hss..s.....p...p.L..tt....h.........t.....t...ts...lhl..l..lPuptlh.hhplpLP......s.......h....t...t.........+..........p...h...ph.Lsh.l.lE-plsp..D..l-p..l..H..h...slh.........................st..p.tp....ts....pV.s..s.l.c..p..phhcphlphLpts.Gl.sh.spl.........hP.........D....h........h....s.....l.Ph........t.tuhs..s.h.p.h.t.t...........................................................................phlh.Rts...tt...p......Gh...u..h......s..h.......s.hh.sh..h..ht.t...hspt..................ltshs..s.Pt..h.s....................................httt.s......tt...........h.......h.....hh.t....hht....sphsLhpG.ap......................................................................................................................................................................................................................	1	37	88	134
+2839	PF04612	T2SM	GspM;	Type II secretion system (T2SS), protein M	Mifsud W, Desvaux M	anon	Pfam-B_5302 (release 7.5)	Family	This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers [1].	25.90	25.90	25.90	26.00	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.74	0.71	-4.44	63	1099	2012-10-02 17:03:51	2003-04-07 12:59:11	7	7	852	2	233	747	121	149.60	22	84.64	CHANGED	hpplpthWpshssREppllsshushLhlslhYhslhpPhppttppspppltptppplshlpppusphpthp.ssssssstst.........uLpsllspoupptGl....slpRhpspGc.plpVtlcsssFssllsWLspLppppGlplpphclsct..............ssGhVslphhh..tts	........................h...lppaatshosRE+thlhssushlhsshhah....h..l....hpPh....ppphpp...t...ppplpphpp.hshlpspAs.plt...shp...tts..ss...pst...................tlspllsposp.tts.l............sl.t.p...lt....p.........u.........c................p........lplhlp.sssasslhpWLstl.p..t.p.h.u..l.plpphpls.tst.............tsG.lplpth.....s.........................................................................	0	63	127	185
+2840	PF00043	GST_C	gluts; GST;	Glutathione S-transferase, C-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants.  Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity.\	\	\	\	The glutathione molecule binds in a cleft between N and  C-terminal domains. The catalytically important residues are proposed  to reside in the N-terminal domain [1]. In plants, GSTs are encoded by  a large gene family (48 GST genes in Arabidopsis) and can be divided  into the phi, tau, theta, zeta, and lambda classes [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.00	0.72	-4.00	58	13485	2012-10-03 01:14:49	2003-04-07 12:59:11	20	103	2532	701	4893	16003	4903	96.70	16	41.41	CHANGED	hhshthphhhhshtts................................pppc.thppsppclhchlphhpphLp......sppah.sG-phohADl..hhhshlt...hhhthphshh.........spaPpLpsahp+lhsps	........................................................................................................................hh................................................................t.........h...t...t.....h..h..p....p.....h...p....c....h.....h..p.h....l....-pt.Lt.............ppsa..l....s.......G......-.....p...h.olA....Dl......s...h.....h...sh..lt............hh.....t...t..h.t..h.s.h....................sphP.p.lptahpclttps.........................................................	1	1323	2464	3783
+2841	PF02798	GST_N	gluts; 	Glutathione S-transferase, N-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	Function: conjugation of reduced glutathione to a variety of  targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST  activity; similarity not previously recognised. * HSP26 family of stress-related proteins. including auxin-regulated  proteins in plants and stringent starvation proteins in E. coli.  Not known to have GST activity. Similarity not previously recognised. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.47	0.72	-3.80	53	5748	2012-10-03 14:45:55	2003-04-07 12:59:11	15	61	1695	674	2420	16335	5075	72.80	24	29.98	CHANGED	hslphashps..tspthRhhLt...htGlpaEt..phhsh....t.....spahphpst...............splPhl.ps......shplspShAIhcYluc	......................................................ha...h.s......ts.t.h.t..h..h.Lp......thG..l...p.....a...-..h.............h..h...l..........s..h..........t...t.....t....p....ht.......sc.a.h..p..h..p.Ph..........................upl..P......sl...p...cs................sht...lh...E.......S.s..A.IhpYLu.....................................................................	0	799	1279	1900
+2842	PF00735	Septin	GTP_CDC; 	Septin	Bateman A	anon	Pfam-B_440 (release 2.1)	Family	Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin.  Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerise to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis [2].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.72	0.70	-5.39	14	2609	2012-10-05 12:31:08	2003-04-07 12:59:11	13	25	286	15	1492	3139	269	234.50	37	62.73	CHANGED	+GhsFTLMVlGcSGLGKoThlNoLFtosLhss.....................pth.tst-.ctcpTlcIc.tpps.lEEc.Gl+LpLoVlDTPGFGDslsN.spsWcsllcYI-cQa-pYLcpEsplpR.pphhDsRVHsCLYFIsPsGHGL+PLDlthMKpLpp+VNllPVIAKADoLTscElpphKppIhp-IcppsIcIap..Pss-ps-..........-E-.hppscpL+pslPFAllGSsphlEt..cGcpVRGRpYPWGlVEVENssHsDFltLRshLlpTHlpDLp-sTpchhYEsYRocpLpshthtscs	.......................................................................pGhpFslh.s.s...G.po.GlGKSTl....lN...o...L....F.t...o....p..h....t..t................................................................................tp.......php..p.....s.l......p.l.p..........t........p...h....p......l......p....E..p.....s..l...+.....l...p..LT.....ll.D..T.s.G....F....G...D...t...l.....s.s...p..............p.......s....a.p.....s....Ih......c.a..I.-....p....Q..a.....-.....p.....Y........Lp....c.........E...........p.....l.....p.....R.........h.....p.....h.....................D.s..Rl.........Hs..CLY........F.I.s....P..........s....G.......H.u.L+.s.LDl.t..h....M.Kp...L...pp..+.......V..N....l.....l.P...lIA.KADo...lo...p.Ehpph..Kp..p........I.h..p-l.t.......p.ps....l..p...........l..Yp......s..t.....p..p.-p..............................................t.....h......p.....stp.....h...p.t....h............P.FAV..lGSp..p....h..p...........h.........t.......s.....+.......h.....l....+....uRpY...s..W.G.h...l.p...V...EN.......p.HsDFhhLRp..h.Ll...p.s.php...DLp-.TpphaYE.taRt.ppLttht.....tst.............................................................................................................................................	4	422	705	1111
+2843	PF00925	GTP_cyclohydro2		GTP cyclohydrolase II	Bateman A	anon	Pfam-B_1147 (release 3.0)	Family	GTP cyclohydrolase II catalyses the first committed step in the biosynthesis of riboflavin.	23.20	23.20	23.60	23.20	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.07	0.71	-5.01	161	5362	2009-09-11 05:22:16	2003-04-07 12:59:11	15	28	3848	3	1428	3867	2940	160.90	39	47.23	CHANGED	lcchspsplsTpa.....G...pFchhsac....sthssppH...lALlpG.......ch.s.sspssLVRlHupshsuDlhuoh...ps-sutpLcpAhctIuc..................................p.Gt.....GVllaL.t...pcucuhuLh...s+lpshthp.cp.uhcshcss..............DhRsY.uluAQILpcLGlp......cl.+LLoNsP.c.KhtuLpuaG..lcVsppl.sh	....................................................................................................phhspsplPTta.....G.....pFphhuac..................s...h..h..s.........s.....p...c.H....................lALlhG.................................................sh....s....s......p....ps..lLlRlHS.EClTGDlhtSh........RC.D...C...G.........QL....c....tAhp....t....I....sc...................................c..Gp....GlllYL.c....QEG..R.G..I..GLh...sKl+...A...Y...t....LQ...-p....GhD....T....l....-....A....N.htLG.h.....................ssDhR.-a.s.luA.pIL+.p.LGlp............cl.RLLT....N...N..P...c..Khpu..Lp..sa.G....lpls-cls........................................	0	444	916	1213
+2844	PF01227	GTP_cyclohydroI	GTP_cyclohydro_I; 	GTP cyclohydrolase I	Finn RD, Bateman A	anon	Prosite	Domain	This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.06	0.71	-4.99	104	4297	2012-10-01 20:59:24	2003-04-07 12:59:11	17	9	3743	160	1127	2999	2646	175.90	44	84.59	CHANGED	hcpul+plL.pslGEDPsREGLh-.TPcRVA+ha.pElasG.hppss....phl.......sphFp.....................hs-h..Vll+cIphhShCEHHhlPFhG.pAHlAYl.P..s.s+VlGLSKlARlV-hau+RhQlQERLTtQIAsslpch.LpPcGVuVll-AcHhCMshR.GVc+ssupThToshpGhFcs-spsRpEFhsllp	........................................h.ptsh+plL.ptl.G..E...Ds..s...R-.GL.h-.T.PpRlA+hY...pElF..u..G.hptss........tplh..........ss.h.Fc..........t.................................h-EMVlV+DIs...haShCEHHhlPFhG......+AHVAYI.P....s..s+V......lG....L..SK..luR.....lV-haA+R.......Q...lQERLTpQIApAlt....ch.L..........p....sp.........G.......VuV.ll.EA.pHh.C.Mph..R..G.Vc.K.sso...tTsTosh..tGh.Fcp.stpsR.pEFLphl.t..........................................	1	354	686	946
+2845	PF04670	Gtr1_RagA		Gtr1/RagA G protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4577 (release 7.5)	Family	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1.\	\	\	     Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family.       The RagA/B proteins are the human homologues of Gtr1.     Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.53	0.70	-5.22	32	723	2012-10-05 12:31:08	2003-04-07 12:59:11	7	10	282	7	491	12357	922	216.90	39	64.20	CHANGED	KlLLMGhptSGKoSh+pllFsNh.sp-ThpLusTl............................cl-pspl+.hutl..slslWDhsGQpsah-s...hhttpp-pIFpsVt......sLlaVh.Dsp........................p..-...htcsltpappslptlhphsPst+laVLlHKhDhlp...c-hRp-hacchtpclpcpsp.........sht.t.................................lshahTSIaDcSLYcAaSpIVppLI.PphsslEphLpphsptsss-clhLF-psohLhlupsstp.sc....t.............................paEphSshI	................................................................................................................+lLLMGhp.tSGKo.........S.......h........p.....p....l......l.............F.........p............p.....h..........s.....p........-....T........h......h.........L.....t...u........T..............................................................c..l...p....+...s.....c...l...p....................u.........l............sh..p.l.W..............Dh.s..G......Q...........s....F.....h..-s.............h............p......p..-...pI...F..p....s....l.s................s.LI..a.V..h..Dsp...................................................c......-.......h..c..s.l..p.p.h...p......p..s...l.....p..t......h.....h.....p......h.....s.......P........s....h.....p........l........l...h...l....H...KhD.....h.....lp..............-.D.....p....+......c..h.........c....-.......h....p...p...c.....l.p....cp...t........shs...........................................................................................ls.h.ahT..S.I.....a.D........c.S....l.a.c.A..a.......Spl...V...pp..L..I...P..plssLEshLp.hsp.....................ph-c...sh...............LF-hsohl..hIusss.p.s..c........hp..........................................paEhhSshI.............................................................................................................................................	1	177	261	390
+2846	PF04138	GtrA		GtrA-like protein	Kerrison ND, Finn RD	anon	COG2246	Family	Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans.  They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans.  It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation.  Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane [1]. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyses the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b)[2]. This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains.  Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose [3].	21.30	21.30	21.40	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.75	0.71	-4.14	175	4541	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	2742	0	1077	3355	691	115.20	18	65.05	CHANGED	+F.sllGshushls....hsl...hhlLh...h...............hthshhlAssluahsuhlhsahhNchaoFcspppt..........htphhpFhhs.shhuhhlshsh...hhlhh.phhth..........h..................................upll...uhhlsh.l...hsalhs+halF	.............................ahhhGs.hss.lls...hsl....hhlhh...h...........................hth.p.h.h....lA..s....hl.uhl...luhlhsahhNc...tasF.cspspt.................hpph..h..p..Fhhh..thh....sh.hl.s....hh.l........hh.hhh...ph...h.sh..............hh......................................................................uhlh....u.hlsh.h....hsalhp+hhlF.......................................................	1	357	710	932
+2847	PF00211	Guanylate_cyc	guanylate_cyc; 	Adenylate and Guanylate cyclase catalytic domain	Finn RD	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.96	0.71	-4.93	21	9831	2012-10-01 23:51:22	2003-04-07 12:59:11	15	564	1435	89	5200	9161	3221	176.30	23	25.87	CHANGED	lhsppacsVolhFuDIsGFTshsspps....shpllphLN-laspFDcLhsppt...lhKlKTIGDsYMssuGls....................cst.tHstphschALshhcth.pshshpp................................pslplRlGlHsGsVluGVlG..h+pscYslaGsTVNlASRMESsGhsscIpl..oppshphLp.......taths.c.uchpl+........G....+............uphpTaalhu	...............................................................................................................................................................h......ppl..sl..h.F.u.............D.l..h.u.....F...T.p..h.sp..phs........................st...p.ll..p.h.L...sc.h.h.......s........t.h.s...p..l.l.p.php............................shh....l......K..h...l................G..D......u......h..h..ss..h..Ghs....................................................................p...p..s...t..p...ss...p.........h..u...l....s....h....h..ct...h....p...p...h.p...hpp.....................................................................................................................s..l....p..l....R....l....G..l..p......s............G.........................l.l...s.....G..s.l......G................p..........p...........p.....a..s....l.h.Gs.s.V......N..........hAu.....R.h....-..u..h.....u..........t...............s.......s................p......l..h..l.......o...p....p.s.h.p.h.lp..................th..t....h..p...h....s....h...l+...................G....................t..........t.....................................................................	0	1996	2930	4185
+2848	PF00625	Guanylate_kin		Guanylate kinase	Bateman A	anon	Bateman A	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.98	0.71	-4.84	12	8050	2012-10-05 12:31:08	2003-04-07 12:59:11	16	166	4712	73	2497	6019	2540	171.00	31	44.42	CHANGED	pt+slllhGPSGsG...+splhpsLlsphscpF.u.hsVs+TTRs.R.sEhpGccYaFl.o+-phppsIppstFlEaup.asushYGTphpslcplhcpu+p...slLDl-.hQusppl+ps.phsPhhlFItsPShpslpch.cthsppstcpltcchsthcpphpph.....FDhllsNssl-cshpcLcchlpst	........................................h...h.lll....s...GPS.Gs.G..............Ksolh.ptL..hp.p.....s.......p........h....t...hSl.S........t................T.TRt........R....u...Eh....c..G......h...c..Y.....a.Fl..oc.-p.F.cp..hl......p......p.s.p..h....l..E.......a...........u....p....h.......h..............u....N...............h........Y..G..T...s.h.p...tl..c..p.h.h.p...p...G..ps...................llL-.l-...hp.........G....s...p.p..l.....+.....p..............p......h...................p........s......h......h....lFl..t..P............P......S.......h............c..............p...........L........c...............p..........R..............l.............t............t............R...............u.............p......-...........s...t....c.....h....l........t...p...........R........h......t......p..A...p.....p..E..h.....p...t..h.....p.........aD..h.l.l....l.N..-..s...l.c....p.A....hpclppllt..........................................................................................................................	1	729	1238	1842
+2849	PF02058	Guanylin		Guanylin precursor	Mian N, Bateman A	anon	IPR000879	Family	\N	25.00	25.00	68.30	68.00	18.60	18.60	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.42	0.72	-3.91	15	87	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	40	5	38	70	0	89.50	45	80.48	CHANGED	puVpVp-ssFoFsLESVKKLK-Lp-......spoPRLtpps..........ssslC.spPsLPp-LpPlCpppsAusIlpRLcsIus..DsCEICs.sACTGC	.........uVhlQ.tsFphpLESVKKLc-Lp-t.....h.sPRltsps...........hPslC.spPsLPp-LpPlCppppAupIhppLcsIAp..csCElCs.sACTGC............	0	2	2	7
+2850	PF05120	GvpG		Gas vesicle protein G 	Yeats C	anon	Yeats C	Domain	These proteins are involved in the formation of gas vesicles ([1]).	27.30	27.30	27.50	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.57	0.72	-4.17	11	122	2009-09-12 20:43:27	2003-04-07 12:59:11	7	2	104	0	50	138	7	76.20	33	85.04	CHANGED	LLplsh.uPlpGllWIu-plpEcA.-pphpD.psLpppLssLphpL-hG-IsEEpF-pcE-ELL.+Lcthtp...htttstttss	.......lhhlsh.uPlcGlhWlu-plp-pA.-cEhh.Dsssl+pcLtpLptth-tGEIoEEEa-ppE-cLLpRLpthtt............st.............	0	19	40	49
+2851	PF05121	GvpK		Gas vesicle protein K  	Yeats C	anon	Yeats C	Domain	These proteins are involved in the formation of gas vesicles ([1]).	25.00	25.00	36.70	31.80	21.30	19.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.75	0.72	-4.16	19	150	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	127	0	62	157	6	87.20	46	75.27	CHANGED	pht......l-s.sscslptGLssLVLTVVELLRQLMEpQAlRRMEpGsLS-splERlGpsL.tLE-pltcLpppaslssp..DLNlDLG.lGsLLsp	.....s.plsh-s-slcpsLspLVLTlVELLRQLMERQAlRRh-sGsLo--QlERlGp.oLMtL-cchp-Lp-paGlpsc..DLNlDLGPLGsLL..................	0	22	49	60
+2852	PF02213	GYF		GYF domain	SMART	anon	Alignment kindly provided by SMART	Domain	The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.	20.50	20.50	20.60	20.50	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.04	0.72	-4.38	79	823	2009-01-15 18:05:59	2003-04-07 12:59:11	11	22	290	12	564	801	13	55.40	30	6.25	CHANGED	hhWhYh....DspuplQGPFsutpMppWhppGYFsssl.l++h........ttsp..pshh.....hpphhtp	...............hWhY+.........DspG.plQ........G.....PFsstpMppWhpsG.YF..s.......s.Lhl++s........pptph.pshh....ph...t................................	0	187	316	466
+2853	PF02895	H-kinase_dim		Signal transducing histidine kinase, homodimeric domain	Griffiths-Jones SR	anon	Structural domain	Domain	This helical bundle domain is the homodimer interface  of the signal transducing histidine kinase family.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.16	0.72	-3.64	148	3074	2009-01-15 18:05:59	2003-04-07 12:59:11	9	46	2055	3	891	2655	208	69.70	34	8.88	CHANGED	spol.RVcsp+LDpLhNLVGELVIscspLtp..hspphp..................................................................pp..........lppshppls....+...........l.sp-LQ-slhph	....................pol.RVsl-+lDpLhNLVGELVIsputLsp..hup.p.hs........................................................................................................................ppc......................Ltp.shspLp...........c.................................................lsp-LQ-uVMph........................................................................................................................	0	298	603	761
+2854	PF03030	H_PPase		Inorganic H+ pyrophosphatase	Griffiths-Jones SR	anon	Pfam-B_1050 (release 6.4)	Family	The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists [1].	22.20	22.20	22.40	22.40	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	682	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.86	0.70	-6.27	139	1540	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	1217	2	611	1460	5022	626.60	43	93.38	CHANGED	ulluLlauhhhhttlhptssGs......................................................................................................................................pcMp-IussIp-GAtAaLp+QY+slulhslll..slll....hhh............................................................uhhsuluFllGAlhSuhAGalGMplus+ANlRTApAA................pptu.............hspALplAF+uGuVhGhhVlGLuLLGluhhahlh..t.......................tthhpslsGauhGAShlAlFARlGGGIaTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDsAGMuADLF.ESYssollAshlL...ushhhsst...................hlhaPLl.luulGIlsSllGsahV+sppss....................................................................................................shhpALppGhhloullshlshhhlsthhh........................................t.st...........h.....tlahsslhGLlsuhlIshlTEYYTussapPV+cIAcu.SpTGsATNIIsGLulGhcSTshPlllIssuIhsuahlu........................GLYGlAlAAsGMLossGhslAlDAYGPloDNAGGIAEMu.tLspcVRphTDtL....................DAVGNTTtAlsKGaAIGSAuLsALsLFuuYsppl............................................................................................................sh..hsl..sltsPhVllGLllGuhlPaLFuuhsMpAVG+AAtphVpEVRRQF+-hPGIh..........................-Gp..s+PDYs+sV-IsTpuAl+EMlhPulLsllsPlllGhl..lG............s.............puLuGhLhGslloGlhhAlhMuNuGGAWDNAKKYIE.........sG..ph.G.G....KGS-A.....HKAAVlGDTVGDPaKDTuGPulN.LIKlhslluLlhs	..................................................................................................................llul.hauhh.hht.lht...s......Gs..................................................................................................................................tcMp-IuttIp-GA.uaLtppYphlslhhlllhlll....hhh.h......................................................shhssl.uFllGAhhSshuGalGMplushANsRTAtAA..................................p..u.............hstuhplAF+uGulhGhhlsuluLLslshhhhlh.......................................t..h.hpslhGauhG.uS.lAlFuRlGGGIaTKuADVGADLVGKV........E.tGIPE..DDP......RNP..AsIADNVGDN..VG....DsAGMuADLF.EoY..s..sohl...........Ashsl...ush..hhh..st..s.........................hhhaPlllsu.h.ulls.Sl.l.Ghh.h.lp.s.t.t.s.s....................................................................................................sh.tuLppuhhlo...ullshlshhhhshhhh.....................................sth.............tlhhsslhGlls.uhlIshlTE.....YYTusshp.............PVpplApu.u.p.T.GsuTslI.tGLulGhpSshhPslhIssuIhsu.ahhu................................GlaG.lAlAA....hGMLuhsuhhlAlDAYGPlsDNAGGIAEM.u......t..l.s.......p.........c...........V.RchTD.tL....................DAlGNT..TtAlsKGaAIGSAuLsAL.sLFuuYhppl..........................................................................................................................................th.....hsl.........slhsPhVllGLh.lGu.hlPalFuuhsMp.AVG+AAhphVpEVRRQF+-hPGIh..........................c..G...p...s..+PD.Ys.+sVcIsTcuAl.+EMlh..Pu.lL.........sllsP...lll.Gh.h..hG.................................stuluGhLhGsllo.G.........lh.hAI.h..uNuGGAWDNAKKhlE..........t.G......th..s...u............................KGS-sH.KAuVsGDTVGDPaKDTuGPulN.LIKlhslluLlh.....................................................................................................................................................................................	0	268	465	553
+2855	PF01725	Ham1p_like		Ham1 family	Bashton M, Bateman A	anon	Pfam-B_2030 (release 4.1)	Domain	This family consists of the HAM1 protein Swiss:P47119 and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae Swiss:P47119 [1]. The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions [1].	19.60	19.60	19.90	19.70	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.10	0.71	-4.93	110	5049	2009-01-15 18:05:59	2003-04-07 12:59:11	11	23	4640	36	1328	3692	2890	187.30	39	82.95	CHANGED	lllATsNptKlcEhpplLsshs....hth............tclt....th.h-l.Es.usoat-NAhhKActhsphh............sts..................sluDDSGLpl-ALsG...hPGlYSARa................u.......................cpt..s.pt....LLch..lpsh.....cs........RsApFhssluhsp..sssp...........hhh................hcGpsc..GpIspps+..Gps.GFGY............DPlFhs.p...sh....spTaAEh...s.cpKN........plSHRu+Alpp.....lhph...L	.................................lllATsNtGKlcE..h..pplLsshs.............hcl...hs.............s-hs.......s....-s.tET.........GtTF..tENAhlKActsu.c.h.s............Ghs...................slADDSGLpVD..AL..s.G.....tP..........G.lYSARa.......................................u.................Gpts..........sDpt...N.p+.........LLpp..Lpsh................cc................R.pApF.hsslshsp......ss.sp.............shl..............................................sc.G.ph...p..Gp.......Ih...p...p...s.+...........Gps...GF.........GY............D...Pl...Fhs..s..th..............scThAEL...st-.E..K.s...............tlSHRupAlctLhp..h........................................................................	0	453	851	1131
+2856	PF04388	Hamartin		Hamartin protein	Bateman A	anon	Wood V	Family	This family includes the hamartin protein which is thought to function as a tumour suppressor.  The hamartin protein interacts with the tuberin protein Pfam:PF03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin Pfam:PF03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking [1].	25.90	25.90	26.00	26.00	22.00	25.80	hmmbuild  -o /dev/null HMM SEED	668	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.39	0.70	-5.85	6	205	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	137	0	142	206	0	536.20	25	62.51	CHANGED	pppssls-LlshL-SssLcpl--V+shlpEpLSs-+GshLVNsLVDYaLpTsSppslclLoolpEPHDKaLLDKhNEshs+sssRLsoLoLLGHVVR+QPsWlHKIu+hPLLsSLLKCLKpDoDVVVLhoulLVLITLLPMIPQosKQaLhDaFDIFGRLu...............SWsl..............+sPG+ss-VaLl.......HL+AuVYS.LFHRLYGMYPCNFlSYLR..paYSMKENh-T....FpEVVK...............................PMLp+VRlHPpLVTGTpDaEL.DPoRWKchEsHDlVhECA+lS...............LDsp..EuSsE-Gh.ohsc...........................SsusPhsusp..h.s.stShP..oshphoh+SspTph.spsphD.st..ssc-slWSPSslCGhuTPPSSh.shsP...hplshpsuh.suchhussGuGpspsus.STPuTos.....P...Pshuss..hhph..ssspsps.ppcc.psp.uhshhsRppp.........................lpsl-+psc.................tpthcsulspElhpl...sptp.c..ssh.Ghc.sh.h..cpLhssptpctp...............LsSo.D+....................Gsssspuu.shp..W.....FTPh-ssh+cp..s......c.pt...s..s.usCptsst..........s.PY-th...F-lALPK...susLFlp+KTtEslc+sttpc.p.......phcccslssoS....PhEVLD.clIppGp-AHsc..cR.hs.so.o.c.spht...P...-ELcslRuQLLL....LHsQLLYERaKRpQHAlR..........NRRL	.............................................................................................................................t....................................................................................ppP..p.hhsplsp.hht.p...s...t...pRl.sLpLL.s.phlphpPsah.apl...ptsLh.slL+sL........phDssssslhsullsLlhhLP....hl....P.p....uh..tp....aL...chFslauRLs.........................sWph....................................................................................................................pps.s..ph..sc.hhl..............................HL....ph...u..l.h........t...LFp...hLYGhYPsNFlsaLR........pha....p.h.c..p.....s..h.ps...........hpcs.lc.........................................PhhpphplHPp.l.l...T..s...o..h......-.pEl..cspRW.......pchE..s.......cDlVhECtp.l.s.............................................Lssh.....pss..ppt......t.......................................................................................................................................................s.s.P.h..ts...................p..s...........t.h..p......t.t..................................................................t....h..os...p...............th...ps..s.........s......s.........................s....p........s............p......h...s..t.s..s........p........shsths...................................t............................t..................th..h...tttp..............................................................................................h.......p..................................tt....s.p..tp..th........h............................................t......................................................................................................................................................................................tt...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	47	66	110
+2857	PF01567	Hanta_G1		Hantavirus glycoprotein G1	Bashton M, Bateman A	anon	Pfam-B_399 (release 4.0)	Family	The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA. 	25.00	25.00	46.60	46.00	17.00	16.40	hmmbuild  --amino -o /dev/null HMM SEED	525	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.86	0.70	-6.25	15	433	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	136	1	0	365	0	303.60	52	49.41	CHANGED	+slYEhKlECPHTVsLGQGhVsGpVELs.lPLsclssLhlESSCNFDl..HsossshQpaTpVsWcKKushs-ossAupsoFEspSpEVsLKGTCslsschhEssaKs...RKTVlCYDLSCNQTaCpPTVaLIuPlpTChoh+SChluLuspRIQVlYEKTYCVoGQLlEGpCFsPs+TlshoQPsHTYDlsTlPlhCFhlsKK...GsshKIhsplEp.lhsKssCT-NslQGYYlChlGupSEPlaVPuh-DaRSuElhS+MlhsP+GEDHDhstsupushRIuGPlpuKVPpTpoo-ThpGlA.FuGlPhYSSLSsLlppsDPcYlFSPGllP-tNHSsCDKKTlPLTWoGalslsGphE+lTsCTVFCTLuGPGASCEAYSEsGIFNISSPTCLVNKsQRFRGoEQplNFVCQRVD.DlVVYCNGQKKVILTKTLVIGQCIYTFTSLFSLlPGVAHSLAVELCVPGlHGWATsALLlTFCFGWlLIPulTLllLKlL+llsa.CS+YosESKFKhILEKVKhEYQKTMGS	.....+sl.-h+hpCPHols..hGps.l.G.sEls.h.lttstphh.ESSCshD...Hpohss.pphTpl.WctKu...pptpuspsoFps.ptplsh+GhChl..phh-psh+.s...++olhCYDLsCNpThCpPTlahIsPl.sC...c.Ch...........................................................................................................................................................................................................................................................................................sl.haCNG.+KhIhT+TLlIGQCIYohTSlFSlhPuVAHSlAlELCVPGhHGWAThhLlhTFCFGWlLIPshThhlLhhLhhhs..hpp.s.-pph+.llp..............	0	0	0	0
+2858	PF01561	Hanta_G2		Hantavirus glycoprotein G2	Bateman A	anon	Pfam-B_401 (release 4.0)	Family	The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA. 	19.30	19.30	20.30	19.30	17.70	19.20	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.75	0.70	-6.09	6	1286	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	278	0	1	760	0	186.40	42	58.72	CHANGED	shsLpPsWoDsAHGVGllPM+TDLELDFSLPSSSpYTYRRcLpNPsNEppplsFHlpI-cQsItA-IQpLGHWhDupaNLKTuFHCYGACpKYtYPWpTAKCahEKDYEYETuWGCNPsDCPGVGTGCTACGlYLDKLKSVGpsaKIISl+YoR+VClQLGsEppCKpIDsNDCLlTsuVKVClIGTlSKFpsGDTLLFLGPLEtGGlIFKpWCToTCpFGDPGDIMSTpsG.hpCPEasGuFRKKCsFATTPlCEYDGNTlSGYpRhlAT+DSFQSFNsT-PHlTss+LEWhDPDuoLRDHINllls+DlsFpsLuENPC+VsLpsuSIDGAWGSGVGFoLsCpVSLTECsoFLTSIKACDpAMCYGAoossLsRGQNTV+IsGKGGHSGSpFpCCHsp-CSppGLpAuAPHLDRVsGhsplDs-KVaDDGAPECGlpCWFpKSGEWlhGILsGNWlVlsVLlVlLILSIhLhSlhCPsR.p+KKu	........................................................................h.............................ChGtC.c.th......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1	1	1
+2859	PF00846	Hanta_nucleocap		Hantavirus nucleocapsid protein	Bateman A	anon	Pfam-B_310 (release 3.0)	Family	\N	21.40	21.40	21.60	54.70	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.39	0.70	-5.78	4	1583	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	297	6	0	1051	1	233.20	54	99.96	CHANGED	MSsLcElQ-pITtHEQQLVhARQKLKDAEKsVEVDPDDVNKSTLQSRRuAVSuLEsKLuELKRQLADhlusQKhsuKPVDPTGlEPDDHLKE+SuLpYGNVLDVNuIDlEEPSGQTADWhuIGsYIluFslPIlLKALYMLSTRGRQTVKENKGTRIRFKDDSSaE-VNGIRKPKHLYVShPTAQSTMKA-EITPGRFRTIsCGLFPAQIKARNIISPVMGVIGFuaFVKDWs-+I-sFLspcCPFL.....Pcstusutt.hhuT.RAYhhsRQstlspocl.DIssLhptApAuusTLhsDIpoPHSsWVFACAPDRCPPTsLYlAGlsELGAFFuILQDMRNTIMASKoVGTAEEKLKKKSAFYQSYLRRTQSMGIQLDQRIIlhYMlpWGKEsVNHFHLGDDMDPELRQLAQuLIDsKVKEISNQEPLKL	..............................................................................................................................................Ih.Ylhshs.sIlLKuLYhLoTRGRQT.K-NKGhRIRhKDDo....lNGIR+PKHLalShPsAQSoMKA-ElTPGRFRThlCGLaPsQIpsRNhhSPVMuVlGF.hhsKDWspRIccahtt.C.Fh..........sts..s.h..t....p.p.h..hN+sYhhpRQtsLst.cst-hptlhpaAtsusso..-pIcSPpu.WlFusAPDRCPPTs..........................................................................................................................................	0	0	0	0
+2860	PF03866	HAP		Hydrophobic abundant protein (HAP)        	Finn RD	anon	DOMO:DM07503;	Family	Expression of HAP is thought to be developmentally regulated and possibly involved in spherule cell wall formation [1].   	22.30	22.30	24.60	24.00	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.16	0.71	-4.45	2	5	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	3	0	0	5	0	146.80	39	58.77	CHANGED	MMKYlFlALChhAlV.LAoEs-.tcusp+..tLsVtG...LlsClVAllApIVuGLLRVIIGLVlTLSGVLpIVlGsVlhLVsslAuLALDlVtuoVsGIhsshLshshlhphlEEsL+s..uQ.LLsGLVpAlhALPLulLVALssLT-ulApuuCshGhStsGhh	...........................MMKYlFlALChhAlV.LAoEs-.tcusp+..tLsVtG...LlcCIVAllAsIVS.GLLRVVlGLVI.TLS.GVLQIVlGlVlpLVDllAuLALDlVsuTVTGIL.NcLLcFDhlhthlEEsL+s..uQ.LLsGLVpAlhALPLulLVALssLT-ulApuuCshGhStsGhh....................	0	0	0	0
+2861	PF01543	HCV_capsid		Hepatitis C virus capsid protein	Bateman A	anon	Swiss-Prot	Family	\N	21.60	21.60	21.70	21.70	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.72	0.71	-4.12	5	9598	2009-01-15 18:05:59	2003-04-07 12:59:11	12	23	146	9	0	6731	0	106.30	87	18.88	CHANGED	STNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARsPEGRoWLSPGTLGPShuhRAlsGpDG.C.....GhAGh..sPtsuRs.Ws.ssPhhR	...............................................................STsPKPQRK.T.K..RN..TN..RRPQDVKFPG..GG..QI..V..G..G...V.YLLPR....RGPR...LG.V..RATR..K.......T...SER.........S..QPR..G..R..R.....QPI.....PKA....RRPEGRoWAQPGYPWP......LYGNEG.h......GWAGWLLSPRGSRPSWGPoDPRRR................	0	0	0	0
+2862	PF01542	HCV_core		Hepatitis C virus core protein	Bateman A	anon	Swiss-Prot	Family	The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases [1]. The N terminus of the core protein is involved in transcriptional repression [2].	21.60	21.60	21.80	21.80	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.38	0.72	-3.59	6	7406	2009-01-15 18:05:59	2003-04-07 12:59:11	13	24	134	0	0	5245	0	59.90	89	8.38	CHANGED	SRNLG+VIDTLTCGFADLMGYIPLVGuPVGG.VARALAHGVRlLEDGINYATGNLPGCSFSIFlLALLSCLTsPAS	...SRNLGKVIDTLTCGFADLMGYIPLVGAPLGG.sARALAHGVRsLEDGVNYATGNL.P.GCSFSIFLLALLSCLTlPAS..............	0	0	0	0
+2863	PF01539	HCV_env		Hepatitis C virus envelope glycoprotein E1	Bateman A	anon	Swiss-Prot	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.44	0.71	-4.83	4	42235	2009-01-15 18:05:59	2003-04-07 12:59:11	12	27	140	1	0	24488	0	72.70	67	29.80	CHANGED	EVRNlSuhYaVTNDCoNsSIsaphsDAlLHsPGCVPC.+-uNsSRCWlsVTPsVAs+psuh.TpsLRpHlDhlVhuATLCSALYVGDLCGuVhLluQhFhhSPp+H.hsQDCNCSIYPGHITGHRMAWDMMMNWSPTsshllA.hhRlPpsllDhIuGAHWGVlhGLAYFSM.GsWAKVlllLLLhAGVD	.....................................................................................................................................................................................................................PssuhVluplLRlPQs..lhD.hl.AGAHW...G..VLAGlAYaSMVGNWAKVLlVhLLFAGVD.............................................................	0	0	0	0
+2864	PF01560	HCV_NS1		Hepatitis C virus non-structural protein E2/NS1	Bateman A	anon	Swiss-Prot	Family	The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein [2].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.19	0.70	-5.99	10	44241	2009-01-15 18:05:59	2003-04-07 12:59:11	12	24	122	3	0	25163	0	104.70	61	44.06	CHANGED	+VTGGssA+TTpulsShFosGu+QcIQLINTNGSWHINRTALNCNDSLpTGFLAuLFYsH+FNSSGCPERhASCRsIDcFcQGWGPIoYss..ssspDpRPYCWHYPPRPCGIVPApoVCGPVYCFTPSPVVVGTTDRpGAPTYoWGENETDVFLLNNTRPPpGNWFGCTWMNSTGFTKTCGAPPCsIGGsGNsT..LlCPTDCFRKHP-ATYoKCGSGPWLTPRChVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLsAACNWTRGERCDLEDRDRSELSPLLLSTTEWQlLPCSFTsLPALSTGLIHLHQNIVDVQYLYGlGSAlsSasIKWEYVlLLFLLLADA	.........................................sTGGusA+sstG.l....s.u....L....F....o....s....GspQsIQLINTNGSWHINRT..ALNCNsSLpT.Ga..lAuL.hYh.p...+...F.NuSGCPER.hASC+slspFsQGW.GPIsasp.....st.s.......-pRP..................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2865	PF01538	HCV_NS2		Hepatitis C virus non-structural protein NS2	Bateman A	anon	Swiss-Prot	Family	The viral genome is translated into a single polyprotein of about 3000 amino acids. Generation of the mature non-structural proteins relies on the activity of viral proteases.  Cleavage at the NS2/NS3 junction is accomplished by a metal-dependent autoprotease encoded within NS2 and the N-terminus of NS3 [1,2].	25.00	25.00	25.10	25.00	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.19	0.71	-4.87	29	2278	2009-09-12 04:23:25	2003-04-07 12:59:11	13	38	114	14	0	2355	0	183.60	72	9.16	CHANGED	DsppuuslGssVlshlslhTLoPsYKthLs+hlWWhQYhlsRsEAhlplWlPPLpsRGGRDu.lIlLsslha...PplsF-lTKhLLAlLGPL....YlLpsuLl+VPYFVRApsLLRsChLlRplAGGKYsQhsLLclGthTGTYlYDHLuPloDWAusGLRDLAVAVEPVlFSPMEpKlITWGADTAACGDIlpGLPVSAR	........................................DpEhAASCGGsVLVGLhhLTLSPaYKtaluhhlWWLQYFlTRsEApLpVWVPPLNVRGGRDA.lILLhCslH...PsLlFDITKLLLAlhGPL....alLQ...AuLh+VPYFVRsQGLlR.hChLsRKhAGGHYVQMAllKLGALTGTYVYsHL.TP.L+DWAHsGLRDLAVAVEPVVFSpMETKlITWGADTAACGDIIsGLPVSAR.....	0	0	0	0
+2866	PF02907	Peptidase_S29	HCV_NS3; 	Hepatitis C virus NS3 protease	Griffiths-Jones SR, Knutson S	anon	Structural domain	Domain	Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold.  The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3.  The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins.  The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.80	0.71	-4.68	9	8309	2012-10-02 13:45:52	2003-04-07 12:59:11	10	46	119	110	1	6342	8	144.80	87	19.64	CHANGED	pGpl.VLuTuTpoahGTClNGVhaTsaHGAuu+TLAGPpGPlsphasssspDlssaPsPsGApSLpPCoCGusclYLlTRcusll.uR++GD.pssLhuPpPlSshKGSSGuPlLCspGHsVGhFpAAlsotGsspulcFl.PhEslsss	......................................EGEVQlVSTATQoFLATClNGVCWTVYHGAGo+TlAuPKGPlhQMYTNVDQDLVGWPAPs.GARSLT.PC.TCG.S..S...D..LYL..V.......T....R...H..A.....DV..IPVR.RRG....D...S.RG.....SL.....L...S..P.....RPlSYL.....KGSSGGPLLCPuGHAVGIFRA..AVCTR..GV..AKAVDFI.PVEshETT...................	0	0	1	1
+2867	PF01006	HCV_NS4a		Hepatitis C virus non-structural protein NS4a	Finn RD, Bateman A	anon	Pfam-B_315 (release 3.0)	Family	NS4a forms an integral part of the NS3 serine protease, as  it is required in a number of cases as a cofactor of cleavage [1,3]. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex [3].	21.00	21.00	21.10	22.60	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.64	0.72	-4.43	15	2766	2009-01-15 18:05:59	2003-04-07 12:59:11	15	42	118	67	1	2514	0	54.10	82	3.25	CHANGED	SsWVLVGGlLAAlAAYChosGSlVIlG+lslsGpP..................sllPD+EshappaDEMEEC	.......STWVLVGGVLAALAAYCLoTGsVVIVGRIlLSGKP..................AlIPDREVLYppFDEMEEC...............................	0	1	1	1
+2868	PF01001	HCV_NS4b		Hepatitis C virus non-structural protein NS4b	Finn RD, Bateman A	anon	Pfam-B_315 (release 3.0)	Family	No precise function has been assigned to NS4b.  However, it is known that NS4b interacts with NS4a and NS3 to form a large replicase complex to direct the viral RNA replication [1].	20.30	20.30	20.40	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.12	0.71	-4.91	11	2035	2009-01-15 18:05:59	2003-04-07 12:59:11	14	36	116	2	0	2032	1	181.50	82	8.46	CHANGED	hp.pshshlssAstpApshpshlpo.....h.s+hpphWsphhhNhhShIthhsuh.shstNPslushhuFhhulooshssphpLhhslLhGhsuotLusPssuhAhssAhhAGuulso.hLu.lllslLuGatuuVsuA.lsFclhuGchs.s-DhhsLlsslhSPGAuVsGVshuslLhphhs..tGuspWhNRLls	..........................FKQKALGLLQTAo+QAEshsPsVpo.....sWp+LEsFWAKHMWNFISGIQYLAGLSTLPGNPA.IASLMAFTAulTSPLTTppTLLFNILGGWVAAQLAsPu.AAoAFVGAGlAGAAlGSlGLGKVLVDILAGYGAGVAGALVAFKIMSGEhPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLIA.......	1	0	0	0
+2869	PF01506	HCV_NS5a		Hepatitis C virus non-structural 5a protein membrane anchor	Paterson M, Bateman A	anon	Bateman A	Family	The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2].  The N-terminal region of the NS5a protein has been used in the construction of the alignment for this family.  The C-terminal region has not been included because it is too heterogeneous.	20.50	20.50	20.60	20.70	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.48	0.72	-6.96	0.72	-4.20	19	5540	2009-01-15 18:05:59	2003-04-07 12:59:11	14	38	115	5	0	5082	0	22.40	82	2.09	CHANGED	usWLhDlWDWVsplLschpshL+	...GSWLRDlWDWICpVLoDFKTWLp..	0	0	0	0
+2870	PF04618	HD-ZIP_N		HD-ZIP protein N terminus	Kerrison ND	anon	DOMO:DM04570;	Domain	This family consists of the N termini of plant homeobox-leucine zipper proteins. Its function is unknown.	21.70	21.70	22.10	22.90	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.77	0.71	-3.54	11	75	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	25	0	39	87	0	93.00	39	35.13	CHANGED	Mt.ccD......cLGL..SLSLuhstppts............................tpss.phshtPs.................sop.pptsuppthhsspss-tpoFLRGIDVNRhPuss............-h.EEE.sG...VSSPNSTlSS.lSG.KRSppctp	..................................................................................................................huh..uhtLs...........................................t......................................t......t..t.....tspphp.....hsh.lRGIDVNRhPsss.............ch.-E-..sG...VS.SPNSTlSS.hSG..KRuppp.s.................................	0	5	21	27
+2871	PF02329	HDC		Histidine carboxylase PI chain	Mian N, Bateman A	anon	Pfam-B_19599 (release 5.2)	Domain	Histidine carboxylase catalyses the formation of histamine from histidine. Cleavage of the proenzyme PI chain yields two subunits,  alpha and beta, which arrange as a hexamer (alpha beta)6. 	25.00	25.00	28.30	28.00	15.80	15.10	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.96	0.70	-5.78	4	71	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	62	34	9	58	3	262.60	46	94.92	CHANGED	csKlpthchD.....ppAISP.+caCpGYhpPGsh.GNGYVoslKlSsGsVDhoD..hLDu...............IVSYDRsEpNDAYlGQINMhTASSFsGlpGtlWGaDlAhp-sltpcK.hPLYpppQ.-Gss.....lPVYsh+PLL-As.cLFGptc..cRRFsshPGuaVlCANKusTA.cPp..tshK.G...hVWSsIuLulhcDRs+susLFlEDAGla..css.....sc--lhtaLEsph+tsTpSls.CGpDpHlha-chaIGatYshhcPGQlGsALoCAPYVoLApsAlPus..hpPuc....LspholSpW.-chshcsL..p..pK	......................................................s...............+hAluPacpascGYh.PGsh.GpGYVosLKVssGsscKT...DD.lLDu...............IVSYDRAEtpsAYlGQINMhTASSFsGhtGplhGaDlhtpspl..cc.pPLap.pQaDGoc.....L.lYDu+PL.-uhlEhFGTpc..pRRa.shPGAalhCANKulTA.RPpp..spshp.GpuYGVWShIAlShupDtscsushFlEDAGlW.tcss.....sE--lhtaLcs+R+uhshSlspCGcDp.....p.....lhacpoaIGFAashMcPGpIGsAlTsuPYlshshsulPut..hhPs.....hpphohspWL-cMsapsL.......t...............	0	4	7	8
+2872	PF02924	HDPD		Bacteriophage lambda head decoration protein D	Griffiths-Jones SR	anon	Structural domain	Domain	\N	29.00	29.00	29.00	29.00	28.40	28.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.43	0.71	-4.31	74	818	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	475	18	82	442	27	110.10	37	93.51	CHANGED	shspshp.hu-hLhhEussph.SR-ssslsuG....sslssGoVLG.....tlsA...o................................................................................................Gc...asshsss.us...DGu.p.sAsulLhtslsAoss.cspsss....lsttu.lspssLsassuhss.sp+ssAhspLssh.uI	..........................................................................p....s.p.thp.hh.usss.s..tTusGshuts.....sssPAhTPLM......LDsu......o......................................................................................................GK...LVsW...........DGp...t....pAVGILs.l.sl-s.T......psslTa...YKSGo..Fsh-slhWP-uss-.pKKtsAFAGoA.....th.................................	0	28	48	67
+2873	PF01517	HDV_ag		Hepatitis delta virus delta antigen	Bateman A	anon	Pfam-B_808 (release 4.0)	Family	The hepatitis delta virus (HDV) encodes a single protein, the hepatitis delta antigen (HDAg).  The central region of this protein has been shown to bind RNA [1].  Several interactions are also mediated by a coiled-coil region at the N terminus of the protein [2].	25.00	25.00	26.00	25.90	21.90	21.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.26	0.71	-4.62	4	1108	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	61	5	0	1072	0	117.60	80	89.58	CHANGED	MSQo-sR+sR+G.REEhLEpWlsuRK+tEELE+DLRKspKpIKKLEE-NPWLGNlhGIIRK.cKDGEGAPPAKRsRpDQMEVDSGPtKRP+tuGFTDpERcDHRRRKALENKKKQLSuGGKpLS+EEEEELRRLT-EDEcRERRlAGPRVGsVNPh-GGPRGAPGGGFVPSMpGVPESPFoRTGEGLDIRGoQtFP	...........................................................................................................................KQLuuGGKsLS+EEEEEL+RLTEEDERRERRVAGPpVGGVNPLEGGsRGAPGGGFVPSMQGVPESPFoRTGEGLDlRGsQGFP.......................	0	0	0	0
+2874	PF02985	HEAT		HEAT repeat	Griffiths-Jones SR	anon	Reference [2]	Repeat	The HEAT repeat family is related to armadillo/beta-catenin-like  repeats (see Pfam:PF00514).	23.50	17.60	23.50	17.60	23.40	17.50	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.53	0.74	-7.59	0.74	-3.39	590	1878	2012-10-11 20:00:59	2003-04-07 12:59:11	17	196	359	47	1138	5988	309	30.50	27	3.66	CHANGED	llshlh..phlp...Ds..s.pVRtsuspslsplsphh	...........hhshlh....phhp....Ds..sspVRpuAspsLsphsp..h.....	0	419	626	897
+2875	PF03130	HEAT_PBS		PBS lyase HEAT-like repeat	Mifsud W, Bateman A	anon	Pfam-B_172 (release 6.5)	Repeat	This family contains a short bi-helical repeat that is related to Pfam:PF02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase Swiss:P31967 Swiss:P31968, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin [1]. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six) [2]. All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond.  Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerised to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerisation reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase [3]. Another member of this family is the NblB protein Swiss:Q9Z3G5, whose similarity to the phycobiliprotein lyases was previously noted [4].  This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif [4].	20.90	13.00	20.90	13.00	20.80	12.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.44	0.74	-7.55	0.74	-2.93	221	340	2012-10-11 20:00:59	2003-04-07 12:59:11	11	54	166	1	174	4509	751	27.50	31	10.24	CHANGED	lRttAstuLuplss..............pulshLhpsLps	....hRhtAAhuLGplts..........................pAl.ssLlpsLp...........................	0	65	142	163
+2876	PF00632	HECT		HECT-domain (ubiquitin-transferase)	Bateman A	anon	Prosite	Domain	The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.	20.40	20.40	20.40	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.28	133	4368	2012-10-03 14:42:41	2003-04-07 12:59:11	20	240	341	23	2797	4212	88	293.50	28	21.16	CHANGED	phl.....spchh.s.sp.........shF...............................................................................h.tsspt....hhh.s....................................................................a...phlGtlluhulhs.......sh.h.....lslpFs.hha+............................................hlh.....................ttt......ls.hpDlt.p.....................lDsphhps.lptlh..t.p.t......................................h...slsFs.h...t......................................................................................................................................................................................................................................................................pL..h..s..G...psl.VTp..pNtpcYlphh....hca.hlpptlppphps........hpcGFt..pll.s......tphlp.hFsspELphllsG.....ps.p.......lshpsLcptsp..ap.tsas.....tss......................ttlphFa.cl..............................lpp.hsp-pppphLpFlTGss+lPh..sGhp.th..........php.....Ipphss..............................................................................................ss..t....LPoApTCa.shLcLPp..........Ysop-hhcc+LhhAlpps.p..s.Fshs	...................................................................................................................................................................................................................................................................................h..l.pphh...s..s.......h...shF...................................................................................t.p.pt........hh....s..............................................................................pphph................................................F...ca.l..G.p.l.lG.h..........Alh.c.........sp..h................l-.h...FshshaK.................................................................................................................tlL...................................................stt.......hs..h.pDlp..p.......................................................................l.D...s..phh...pu.Lhh...lh......pts..t...................................................................................tl......sLs..Fs..ls.pt.....................s.h.......................................................................................................................................................................................................................................................p..........................h-.L....h.ss..G..................psl....V...T...p.............cN.+.p-.Yl.c.hh.............spa..ph....p....p....t....l..p.p...Q.hpA......................Fh.....c..G.Ft...pl..l.s........................p..h.....l..p.....hF.....s.........pE..L...c..h...l.l.s.G..................s..c.............................lDl..p..c....hcpp........opY..........c...tsas.............ts..p..............................hl....p...h.F.W....cs........................................................l....pp....h....s....p....-.......c....+.....t....ch...L..p..F.lT....GosR.....lPh........tG......Ft..tL..................................phs.......I..pphs.t.........................................................................................................................................................................................ts...p.....LPp.u.p...T...............C..a..N.....h.....LcLP..............Y...p.o.....h......c.....hLcc+LhhAlp.ps.t.u.Ft.............................................................................	0	1023	1454	2163
+2877	PF03451	HELP		HELP motif	Bateman A, Suprenant KA	anon	[1]	Family	The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family.  The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain [1].  In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation [2].  The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.	21.90	21.90	22.20	22.10	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.51	0.72	-4.46	7	705	2009-01-15 18:05:59	2003-04-07 12:59:11	9	111	107	0	408	642	23	69.00	42	8.56	CHANGED	cpG.l+halRG+slshhhPsc.h.shc.sscp-hPsp+LcL-WVYGYRG+DsRsNlalLPTGEllYFhAuVsVLash-	............................................................Ppt........p..tt.c.p.chP.....s..p.cL+L-.a.......V.....YG...YRG.+DC.R.s.NL..a.hL.s.............s......G.......E........l.VYalAuVsVlYNh..........................	0	124	162	260
+2878	PF03996	Hema_esterase		Hemagglutinin esterase	Finn RD, Marshall M	anon	Pfam-B_505 (release 5.5)	Domain	\N	25.00	25.00	50.60	50.60	20.70	19.60	hmmbuild  -o /dev/null --hand HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.92	0.70	-5.16	6	382	2012-10-02 11:02:24	2003-04-07 12:59:11	10	4	208	19	0	295	0	323.80	45	74.88	CHANGED	hspplLlssShuhshGF...............scPhsssSHLN.sDWhhFGDSRSDC...sNsu.Pp.shhshpss.phSuK.Suphh.SlFts.HhoDah..YpGpGpphVFYEGVNFSPatuacChspG.sphWhs.KspFYsplYchhup.RslSlVNl.hshss.shssulCKssspshspsshlhpppshssphhpsctshshsshs.............tsCphhhsshplaNspthusph.shhspastslsshs.hssssTtspssuhDhsCcYLtLpPGsYpuhSsthhLshPoKuhChcphc.hsPVQsVpShWspsRpSDshsu.ACp.sPYChFhNpossYsG..stDsHHGDtchRplLSGLhYsusCISQQGshshsssSoph.hhP..YG+CPpAAclts	....................................................................................................................................s.PpsssShLN.usWhhFGDSRoDp...sNss..p.u.hshpsA.phpuh.uuphh.ShFts.thsDah..YpGpGpphlFYEGVN..aoPatAhcChpps....Whp.KhtF.pplYc.hu..+shohVNs..hh.s.t.stuhstsss.sh.psshlhpptshs...htsctshh..s.................s..hh.shphastchhsshh.h..sp.hhshsshs.hs.s.Tts.sss.shpCchl.L.sGpY.shSs.hhLhhPp+uhChshpc.hsPVpsVpShWspsRpSD.hss.AC..sPhChhhppppsYlG...hD.pHGDtthpplLSGL.Ypu.ChSQpGhhp.sss.o...LhP..aGRCPhAAc.ps.............................................................	0	0	0	0
+2879	PF02710	Hema_HEFG		Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein	Finn RD, Bashton M, Bateman A	anon	Pfam-B_505 (release 5.5)	Family	\N	25.00	25.00	36.90	36.90	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.17	0.71	-3.92	12	364	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	203	19	0	284	0	131.10	47	29.16	CHANGED	pFYppLYphhuh.Rslphlsl...p.shshost.psshCp....ssphh.sNPpalshpsshss........spFsLsu......CscaLVPhChh...suthhssst.....hhps.thaYs.Do.hhYGasssss......stthDhsCcYL.lcPGsYpAhossh	..F.pplYchhu..+slohVNs...shshpsost.ssu.Cp......s.hLpNPAhhspEsp.s-.hht.E..A.FsLss......Cc.alVs.ChF...stcshsppt.....hhs..QhhYspsstVlhGLsspho......sss.shpCchl.LpPGpYpshSs..t..	0	0	0	0
+2880	PF00509	Hemagglutinin		Haemagglutinin	Finn RD	anon	Pfam-B_26 (release 1.0)	Family	Hemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalises the virus by endocytosis.  The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	550	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.87	0.70	-6.37	15	50634	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	45867	505	5	30865	0	432.00	51	96.33	CHANGED	IClGYHusNSocpVcTlhEpsVsVTpupELlEos+ssclCshp.....stpPlcLtcColtGhlLGNPpCDhhLs.psWSYIlERssu.suhCYPGsl.shEELRplluSstpap+lchhscs.sWssshsss....GsosACppsuss.uFaRslsWLsKp.....psssYPshssoYsNTcsp-hLhlWGIHHPsossEQssLYpsussh.loVuTpohspsasPpIGsRPtVs..G...QuGRhcaYWoll+PG-olsFpoNGNLIAPcauaplsspu.u.sIhposlslssCsocCQTstGuINospPFQN.lsphsIGcCPKYVKssSL+LATGhRNVPplp....pRGLFGAIAGFIEGGWpGhIDGWYGF+HpNupGoGhAADpcSTQcAIDpITsKlNslI-KMNppF-sls+EFsclEcRIpsLsc+l-DshhDlWoYNAELLVLLENp+TLDhHDSNVpNLaE+VRRQLR-NAc-tGNGCFElaHKCDspCMESIRNGTYDHscYcEEu+lNRpcIsGVKLcSss.sYcILsIYSslASSLlLsshlhGhlhWsCpNGshRCpICI	.................lClGaHAsssss...hVcTlh-cplpVTpuspLlpsppsG+lCs.......shtsLchtsColhshlLGsPpC-sh.s.ppWshlVE+usu..pusCYPhDhsDYppLRplluSs...tphEhhscs.sW.stssps....GsS.uAC.+susp.SFappLhWLs+......psssYPsLshoasNscpp-hLhlWGlHHPs.o..ss-QpsLYtpusuh.loVuTp+hppphhPpIusRP+VR...s.....QsGRIshYWTllcPGDtlhhpusGNLIAPRhsFtlpps..........tSuIhpSDsPlspCso.pC.TPpG...uIsss...hPFQN.lp.lThGtCP+YVKpspL+LAT.GhRNlP.php...........oR.G.......lFGAIAGFIEsGWpGhlsGW.aGapppstpG.u.AAD..................................................................................................................................................................................................................................................	0	2	4	4
+2881	PF01126	Heme_oxygenase	Heme_oxygnease;	Heme oxygenase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.20	20.20	20.30	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.32	0.71	-4.76	18	1215	2012-10-02 21:56:19	2003-04-07 12:59:11	15	7	902	120	452	1089	282	182.30	20	75.77	CHANGED	ssLuppLRcuT+csHshAENssFsKsFLpG.lscpsY+pllusLYalYpAlEcEhccp+spshhuslhFP.ELpRpsuLccDLsaaa.G.ssWcptlpsosAsptYVpRl+clusp...pPcLLlAHuYTRYLGDLSGGQlLK+................................................IAppuhsLsss.pGhuFYcFssls...spptFKppYRptLssl.ls-pppppllcEAspAFthNhplFp-	..............................................................................h..hsttl+ttTpt.Hpth.-........p..hhtt...h.....................hs.h.ptahphltt.ah.......hap....s.......lE.t....th................t........................................................................ht.h.h....s...pL...h...R.pt.t.LtpDlt.hh............h..s..............p.h...........t.........t........................h..........t.......s...............................s.......h..t......t...h......s..t..c..l..c....p...............l......spp...........pst.....hhluahYsh.h.u.sLu.GGp.ll.++................................................................................hhtpt..hs..l...s.t.....p..............t..........u..hp..........ahp...a..s...s...................sttth.hptac...pt...l...s...p..l..s...h...s.t.p.p.p...p.phlppAppuFth.hthht..................................................................................................................	0	109	241	359
+2882	PF00372	Hemocyanin_M	hemocyanin; 	Hemocyanin, copper containing domain	Finn RD, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes arthropod hemocyanins and insect larval storage proteins.	20.80	20.80	21.20	21.10	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.72	0.70	-5.11	14	743	2012-10-01 19:27:11	2003-04-07 12:59:11	14	15	199	48	195	807	0	247.20	31	41.35	CHANGED	s.aElaPphFssu-sIp+Aaph............chtp.....................................................ph.-cs............hlhcsphosslh..spEp+luYFpEDIGlNsaaaaaHhsYPFaasschaGthK-R+GElaaYhaQQlhARYchERLSNGhscl..FpahcslcpGYhP.hhplssGh.au.RPsshplcshcshc.lp.h-caccpIh-uIppGalps.cGppIsLccscul-hLGsllpu....ss-sssh.Y.atoLcshu+hhluthscPps+aphsPulh-papTSLRDPlFYpha+hIsNlFpc	.....................................................................................ElhP.hFhs.sphl.pu.......................................................................................................................................t....................hhl...h..s..ao...s...s...h.....p.Ep.+luYFpE..DlGlNsaa.......aaaHhs.Y.........P....h....h...h..p.....p....h...........s....h.p.K.D......R..+GELF.aY.hHpQllAR...YphERLo.N....sLsclp.h...s.a.h.c..s.l.p..G.YhP..hh.p.h.h.s...G.ht.as..sR......ssh...ph......p......c.....h.............p.......p......h.....p..................l......p....chppacpRlh-AIp.pGa....l....hs.t....sG.....p.p..lsL.p......p..................c........u....I-hLGs.hlcu...........s....Ss.s.pa..Y.....G.s.lashu+hhl.uh.p-.sp..tc...a..................suVhtch....p.TuhRDPh....F.Yphaphlssha........................................................................	0	61	85	176
+2883	PF03723	Hemocyanin_C	hemocyanin_C; 	Hemocyanin, ig-like domain	Finn RD, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes arthropod hemocyanins and insect larval storage proteins.	26.40	26.40	26.40	26.70	22.10	26.30	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.60	0.70	-5.24	163	687	2009-09-11 10:37:18	2003-04-07 12:59:11	9	13	179	48	209	753	0	235.80	31	36.26	CHANGED	ssYTc-......-LpFsGVplssVpV.p..........LhTaa-ph-h-losul.shs.........................schslhs+hp+LNHcPFsY..pIpVps......spssst..sVRIFluPKaDph..Gp.hshs-pRhhhlElD+FhhcLpsGpNsI...sRpSp-SslTlscphoaccLhpph.ts.sttt.h...........php.stCGaPp+.hLLPKGpt.pGhsapLFVhlosaptspl.tpt........s.sshshCGht.sppYsDp+PhGaPFDR.l.........spht.a.h....NMthpDVpIhac	...................................................sYoppcLtasG..VplpslpV.sp.............................LhTaacp.-hDlssulshs..............................phslhu+hp+LsHcPFsaplsVp.s......spstpt.......sVRlFluPKhDph..G.p.....h.s...h.p-pRhh.hlElDcFhhp.LpsG..p..N..sI...pRpSp-ssholspchoap.pLhpph.tsh.p.t...h...........ph.ph...stCG....aPp+.hL..LP+G.p..p.Gh...hpLalhlosaptsps..tp......................p.ssh.h.CGht..sphasDp+shGaPFDR.l..........ppht.h.h...sNhhhp-lhIha....................................	0	59	86	184
+2884	PF03722	Hemocyanin_N	hemocyanin_N; 	Hemocyanin, all-alpha domain	Finn RD, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes arthropod hemocyanins and insect larval storage proteins.	21.70	21.70	22.60	21.70	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.50	0.71	-3.97	111	668	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	164	48	193	736	0	113.70	27	17.52	CHANGED	shhpKQpplhpLhp+lpps...h.t.chhplupsap.......tp.t.a...pcsch...spp.hhp.h+pshhLs+schFSlappcphcEAhtLaclLatA..KDa-sFh+sAsasRpplNEGhFlYAlslAllHRsDscGl	.............................................................t..lh.lh.ph.t............phhthspph.........t....t.h....tp.ph......hpp..hh..hphs.hLs+sphFSla.tcHtcpAh.tLhclhhtu....pDa-sFhpsAsa..uRp+lNpshFlYAlolAllHRsDscsl.................	0	49	75	166
+2885	PF00045	Hemopexin	hemopexin; 	Hemopexin	Ponting C, Bateman A, Sonnhammer ELL	anon	SMART	Repeat	Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).	21.30	21.30	21.50	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.30	0.72	-4.22	76	5321	2009-01-15 18:05:59	2003-04-07 12:59:11	14	87	208	96	2483	4600	17	44.70	26	26.74	CHANGED	lDAshphp.......schaFF+GspaWchssp......php.shPp.lssh..ulss	.................hDAshphpt..........uchaFF..K..G.....s..p..aW.+...assp..........php...s...u...aP...+.lsph...uls.........................	0	348	533	1140
+2886	PF05171	HemS		Haemin-degrading HemS.ChuX domain	Finn RD, Bateman A	anon	COG3720	Domain	The Yersinia enterocolitica O:8 periplasmic binding-protein- dependent transport system consisted of four proteins: the periplasmic haemin-binding protein HemT, the haemin permease protein HemU, the ATP-binding hydrophilic protein HemV and the haemin-degrading protein HemS (this family). The structure for HemS has been solved and consists of a tandem repeat of this domain.	20.40	20.40	20.50	20.40	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.37	0.71	-4.33	108	1015	2012-10-01 19:49:10	2003-04-07 12:59:11	7	7	499	8	260	1007	60	130.00	33	72.42	CHANGED	sloctphltstsu......p...hsppls..ss.........hpplLpthtphG.tlMshstNcuslp.+sGsh..pslp.t.....G........hh.lLss...s..hsL+LhhsphspuasVc+sT......pc.G..hhpSlphFDspGsslhplaspcp....s-hs..uWctLlp..pL	.......................................loctphhtshss.........c......h.Ah+lp...ss..........l.tplLps.hppsG...clMshstNc.usVp.psGsh..p.p..l....p...t.......s.....t.......hh....l.lss...p....hsL..+..Lh.sphAps.aslccsT.................sc..G...hhpSlphFDtpGs..t..ltpl..aupcp..........s-hssWcplluph.......................	0	53	127	187
+2887	PF00906	Hepatitis_core		Hepatitis core antigen	Bateman A	anon	Pfam-B_8 (release 3.0)	Domain	The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA [1]. There is some experimental evidence to support this [2].	22.60	17.00	22.70	22.70	22.50	16.80	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.32	0.71	-4.63	12	7177	2009-01-15 18:05:59	2003-04-07 12:59:11	15	10	91	27	0	5167	0	125.70	89	88.87	CHANGED	DIDPYKEFGAoVELLSFLPsDFFPSlRDLl.DTAsAL..Yp-ALpSsEHC..SsHHTAL....RQAlhCWtElhsLuoWVGsNLpDPsuR-LVVsY.........................................VNsshGLKhRQLLWFHlSCLhFGR-TVlEYLVSFGVWIRTPssYRP.NAPILSTLPETsVVRp..Ru.....RoPRRRTPSPR.........RRRSQSPRRR.................RSQS.pSpC	.............DIDPYKEFGAoVELLSF.LPSDFFPSlRDLL.DTASAL..YREALESPEHC..SPHHTAL....RQAl.lCWG-LMsLAoWVGsNLpD.huR-hVVsY.........................................VNsphGLKhRQlLWFHlSCLTFG+psVlEYLVShtsh.....................................................................................................................	0	0	0	0
+2888	PF01771	Herpes_alk_exo		Herpesvirus alkaline exonuclease	Bashton M, Bateman A	anon	Pfam-B_822 (release 4.2)	Family	This family includes various alkaline exonucleases from members of the herpesviridae. Alkaline exonuclease  appears to have an important role in the replication of herpes simplex virus [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.50	0.70	-6.03	14	226	2012-10-11 20:44:43	2003-04-07 12:59:11	12	6	154	6	18	307	11	373.60	23	77.26	CHANGED	s.hsplsshshsp.FLcss.htphhu......pptsthstlRasYhahlhh......phsshhusst............................ssshhtcthttshsst...............................plsplhtts....................pphsscttpplhhhlEttTRGQu-NsLWclLRcGllouSKhhausp.t.phs.+hFps.shpsspasuu......sltFGh+sEpsl+sLlsphhs.......sc.................................tsspshGhLhsPpsGlhGsSLDhhss..s.tpuptshl.hpsssplaEIKCRaKYLFsKs-..DPhhptYtpLhppPsttsLtcFlhSIs+PuVEahssG+lPots-aLlTpDtsWc.ts.p++tshsst+ph...htcplthNptspSpVhlhs......DPstspupIsh...................................................cuthplslFsNPRHsYFaQlLlQphVl.ppYlphpssP....pLso.tshlsouhFRc.......R.tssshsCplssc...tl..sscIPllLIlTPVhlstp.shpchlpputshWp.psspcpasph.sWsssus	...............................................................................................................................................................................................................................................................................................................................................................................................................................hs.t.h.t...pth..hh....hlEptTRuQucs.....tLWplLRhshhTASphp.sst...t............s.....s..t..hhp.........h.p...s....t...hp.ss.............ulhFGhppEs..........hs.+.......s......l.ltphhht................................................tsshsCGhhhsspsGhhGAShDh.hhs........p.s..s...h..t..h.h.aElKCRhKYhhp.....p.h.t...tlhtt.s...hhthl.sh..Pslpah..tt.Pt.t-hLhs.p..h........h.............thh..Nt...S.lhlhs.................t...ttt.h.................................................................................h..shFhNs+H..ahQhhlQ.hlh.t.a.t...............s.hhp....t........R.................................t.tlPhhhllTPl.hs...hh..h.tts...ht.t.ht..............h..................................................................................	0	14	14	18
+2889	PF04793	Herpes_BBRF1		BRRF1-like protein	Waterfield DI, Finn RD	anon	Pfam-B_6247 (release 7.5)	Family	Family of herpesvirus proteins including Epstein-barr virus protein BBRF1.   	25.00	25.00	86.70	86.40	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.65	0.70	-5.64	10	28	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	21	0	0	22	0	273.10	29	93.11	CHANGED	aHYP-lssllpElcslsl.ssshsppppPssp.LERulaLsKlhQlLhQHRppEppIlPplpsNlhYaLspLpchsssctpphlpslLscl..sssDhtLsscLsphlsclLpl+YPsthsl.....sppssshspWCLpahlGlspph+phlsssLsstc.sShPSlpshspLu+pLFhspuhhpEsasDssFNh.hNQlVaWTsslchappClapchls-oIsshpsLLKpEl+uFhpWhcppp......phpshthlcahcahlcplTsssocsclsElhphLpcsK...+sLhs	aHYPslspllpphsslsl..ssh.s.tppPhhs.lcRuLaLs+lhQlLhQH+ppEphIlPplpspltYhLptLpchsssch.pphI...tplLshl..sssshsLppcLhphlsclLthcYPpthsl........ssshtpWCLpahl.Glotph+phlpshlsotp.sshPShpshspls+pLFhspsh..EshtcpsFN..hN.slFWTsslphappCIapphlhcpIssh.sLLKtEl+pFhsWhc.pc......phtshshlpahcalhcplTsssoph.hsElhshL+HsK...+sL......	0	0	0	0
+2891	PF05109	Herpes_BLLF1		Herpes virus major outer envelope glycoprotein (BLLF1)	Moxon SJ	anon	Pfam-B_6348 (release 7.7)	Family	This family consists of the BLLF1 viral late glycoprotein, also termed  gp350/220. It is the most abundantly expressed glycoprotein in the viral  envelope of the Herpesviruses and is the major antigen responsible for  stimulating the production of neutralising antibodies in vivo [1].	25.00	25.00	409.60	409.50	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	830	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.69	0.70	-13.61	0.70	-6.58	3	270	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	6	1	0	74	0	437.20	62	100.00	CHANGED	MEAALLLCQYTlQSVlpLsuDDPGFFNVElLpFPFYP+CcVCTADVNlTIlFcVGscs++L-LsFGs.LTPpTKuIYQPlHAoGGpENATsLFlLELLGAGpMALTMRSpphPINlSc.-EppVSlEAlhVYFpDsFDlhWCH+VpMp-PVYLIPcplPPll..WNcCNSTNITAVVRAQGMDlTVPISLPTpPp-SsFSl+hEMsGNGIDhpCchEss.ISPVLPGsNsFsITCSGDKPHFASGGILTPsSPssTPsPhsGYsYSLpLsPRPVPRFLGNsSpLYlaYohsGPcu-GGDaCIposIsFSDcLPTsQDMPssTQsloYTGsNATYpLsMAsSEs.NTAPNVTVTAFWAWuNsTpoDFKCKWsLsTssQpPsGCER.........huGtFsSNRTFElTVusssssuKTLIIoRsATNsTsssaKVlFoKAPDoTpos.hl.ThsastPppTTulPoosplP.....PsoouPThpstDPTSsTPTGhTS.................SphP-sTSPTSsoTosTPNATSPTsssT..TPNATSPTosKTSs.......TPNsTSPTslVoGsTosATSPPoGsTSs........PNATSPpVuEpSP.sNTs.........TPsVTpsPSVlTssshsuphGsoSSPTSuhouhPpo.....ssTPRsNSTSsTP.LTSsHPTGGcNITEsTPuuPST....sHVSTuSPuPsPGTTSQsuGPGNSSTSscPGts+VTcGhPspNATSPSAPSuQcTsVPTsTssGGKANsTT..KcToGSshtuSTpPsTstGusuTTs...YNATT..PPosSSpLRPRWT.TuPPsTTsQATVPVPPTp+P-aSNLSMLVLQWASLuVLTLLLLLVluDCAFRRsSSplHTYTa..PPYDDu.ETtV	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2892	PF04633	Herpes_BMRF2		Herpesvirus BMRF2 protein	Mifsud W	anon	Pfam-B_5353 (release 7.5)	Family	\N	25.00	25.00	190.20	190.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.20	0.70	-5.48	10	24	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	21	0	0	22	0	348.00	30	98.13	CHANGED	pschsLshsuFssGsLAAoPFlWCFIFtoLaohshassWpotlah.WuhsssplshlhaCllphsp..hsRtlchlsslslhsshhsFhhpshshuhhshlPsLFllNhlhLslWlhlsh-sVYLCPsIhp+YaELGFLsAhslY.YlllppplaloslFhhPFhlFlshGlhuLpsl+++shYcpGlpRR+uIF.spsuKYhshShppshchssh-LlllssLlsuhssuhluLslaTclhhGlspYlaLFhsGshsCGGlhl.sSphhshVashluslshhLlalhsstlshhsppshlhslhlhsahpAlGCplphIRpKL++slNuPpllLslCsLsNlllslshhllsK	......schsLshtuFshGhLAAoPFlWCFIFtoLaohslaoshpshlah.WuhsssplhhlhaCllshpp..hsRtlchhhhhslhsshhsFhhpshshuhhhshPsLFllNhhhLhlWshlsh-lVYlCPsIhpRYaELGFLsAhhla.YhlltptlalosVFhhPFhlFlshGhhuLtsh+c+slapsGlpRR+uIF.htps+Yhshohppshchssh-lhslhhLlhshssuhlultlhoclhhGlspYhhLFhsGhhsssGlhl.pSphhshVhhhluslhhhllalhtsthsshhppshlhslhlh.hhpAluC.lphlRpKLp+slNuPphhLtlChlsNhllslshhslsK..	0	0	0	0
+2893	PF04682	Herpes_BTRF1		Herpesvirus BTRF1 protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4518 (release 7.5)	Family	Herpesvirus protein.	25.00	25.00	125.00	124.80	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.59	0.70	-5.05	12	30	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	25	0	0	27	0	245.40	37	66.63	CHANGED	hshhsshK+VpINEutNpthha-spp.l.phPh...................ssh.s+sIlKp......stsspst.....hhAplFaAhut.hP.plGpsPspsasTlhIMsRSpNSLphlP.shplsslQ+LFLKHVLLtchGLENshpsF.tlasp.lsslospQh.phFcpllppsKp+lEDhVFsLNSIspt.FptsVpssssss.thphAhEKYFLMFPPtD+.psAlpFuusllclICpGsshsclltFLp+YlsIpccsstsNhlKlYALLol	.........................hhpshK+VplsEusNphhhh..pp.l.ph.....................pht.s+sIlK+...s.ss..p.tsh.t.t.hAplFaslup.hP.plGpuPsssasolhIMsRSpNSLphlP.shclsslQHLFLKHVLLpphGLENhlpsFpslYss.hsslospph.ctFEpllppsKpplEDhVFCLNoIssppFptsVpssssss.slhpAhEKYFlMFPPps+.psAlpFuAsll-lICpGsslsclltaLsKYhsIp+csstssLlKlYALLol.	0	0	0	0
+2894	PF04929	Herpes_DNAp_acc		Herpes DNA replication accessory factor 	Finn RD	anon	Pfam-B_5837 (release 7.6)	Family	Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate.  The Epstein-Barr virus (EBV) BMRF1 protein is an essential component of the viral DNA polymerase and is absolutely required for lytic virus replication [2]. BMRF1 is also a transactivator [2].  This family is predicted to have a UL42 like structure [1].	25.00	25.00	254.70	254.30	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.33	0.70	-5.49	11	24	2009-09-11 06:58:28	2003-04-07 12:59:11	7	1	21	10	0	25	0	391.10	34	98.89	CHANGED	shuhplcsssLsptsKlY-HlKuclK.sGlIQ......lsG.sssPsLullSslGssGlLsFclp.sAluphpspp.......phscssolSFRN.puhGsTFlaoRELFGssVcsAsltFY+R....tssupP..pFV+splpYsDslTpTpHTSsl.pstl.Phpcplpsspshu+VlLosKTsshLQKWLRQpKo+t..psV+VslNETLuVll.loVG-soKTlDaKsss..t.sstshsssKstDsGsVpsDssspVul-uLhsALulCKIPGlhlPsh+FauusILEVsGs.lKpup.ssssLSVhLLsssspscssst...sh..........sulsspsppsssssssuPP..............................tsspspopp.sssotsPssshs+s.t...ohpR..KRpsc.........pcc+sKKhKhsFNPLI	..phshplcsssLuphuKlY-HlKup.lK.sGlIQ......lsGss.ssPsLulluslGsuGlLshclp.sAluphhspp.......ptspssuhSFRN.puhGsTFlaoRELFGssVcsssltFY+R....psuupP..pFV+splpYsDsso.pTpHTSsl.pshh.Php-+lcssthhu+VlLssKTushLQKWLRQp+op...psV+VolNEsLuVhs.hTlG-soKTlDaKPhs....ss.tttshsssKstDsGsVpsDssspVul-SLhAALulCKIPGshlPsl+FauusILEVsGs.lpsus.sslcLSVlLhpssspspssus...s.........................sulpppspp..ssssssssPP................................s.tts.psposs.u.sopsPssshp+s..ss..p.p+..KRpucp......pppcc+sKKsKhsFNPLI.	0	0	0	0
+2895	PF01673	Herpes_env		Herpesvirus putative major envelope glycoprotein	Bashton M, Bateman A	anon	Pfam-B_1084 (release 4.1)	Family	This family consists of probable major envelope glycoproteins from members of the herpesviridae including herpes simplex  virus, human cytomegalovirus and varicella-zoster virus. Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication. 	25.00	25.00	54.20	54.10	21.50	17.90	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-13.16	0.70	-5.94	32	143	2009-09-11 13:51:45	2003-04-07 12:59:11	13	2	85	0	0	123	0	494.60	31	93.89	CHANGED	lh...sEllhtuHhhpl.........shhssshtsssss................................................................................ph..h..s.........hsssLslDpsCplCpllshhh+c.s.s.pWhtDYAhLChKCltAPhsssuohlsAhEFlalhcpHF.stptss...hFspphlolhDlphHFFlppCF+...............................tpssshlphuNhoaltpuhhRuhLhsptssshshhphh...........................................s.t.shtthccpscsssCs..............................tp......................................th.tt................thsassLlhhlhuGossh.tts.....................h..lhts+tptlcphhpppt..................................ht.ssps-hshGPlLloslhthpp+spTso.ClLCpllss+sp.hhsL+pL+pcllsaspNNlpLhDpIp.lLsshts......................................hs.hpDtsthhtll+tsGspulaKHhFCDPhCAhNttpTsPpVL..Fspsss...ccLphhKAplAstNpatspl...CptLasLshhFKuaQlhphp...tTslusFl+-hstlL++HslsLls.taTlshYV	.........................................hsELLhtuH.hpl....sh.p..t.s.sss..ss...s........................................................................t....-hs.h.ts.........hsssLulDptChlCphlplhh+p....shs.pWltDYuhLChKChtAPhsAhushlsAhEFlalhcpHF.phptss...hFtppsLTlhDlphHFFlppCFc.....................................ppss..stVphsNhohht.ussRAhlhs.sssshsttpth............................................s.tthltsac-pup.hc................................................................................................................sassLlhhhhuGTssh.pss.....................hpths.ts+tttlcthhpspp...............................t.hh..ssps-hshGPlhhoslhthps+spTss.CLLCpLlhspha.hlsLRcL+pcllsYspNNsplhDpIt.Vlssh.st.....................................ts.htssshhhtll+tsGspuIaKHhFCDPhCAhs.hpssPtVLFscsss.....cclphhKAtlAssNhat.uRl...CttlhhLhahFKsaQlhh.p....TtlusFlR-hstlLcpHslsLls.paTlspYV................................................	0	0	0	0
+2896	PF02480	Herpes_gE		Alphaherpesvirus glycoprotein E	Mian N, Bateman A	anon	Pfam-B_849 (release 5.4)	Family	Glycoprotein E (gE) of Alphaherpesvirus forms a complex with  glycoprotein I (gI) (Pfam:PF01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.67	0.70	-6.22	19	334	2012-10-03 02:52:13	2003-04-07 12:59:11	11	15	88	4	23	302	1	298.90	33	76.66	CHANGED	Phsssshhscs.................WshL.ssss......t.t.lClp.s.ChtDllls...spC...shchsls.......hAphhh..tshppsssshhh..ssslhsphsssp.....ssLpltsAstssuGlYsLhsp...sssstsptss..hhVtVtstttt....................................hsstPh.....h.hsP..pp+Gsphplpsa+uhlassGDoFplslplpsthaD..ssFshplcWhahcs.sspCs.h+IYEsClaHPptPpCLpPsc.ssCuFuSshhupplus+hYtsCstt....hsscC..sssphctsstlpht...sssssLhhpsAssssoGLYV..........hVlhhNGHlcAWsYsllSTssp.ahNslp-hshPth................ssssssssssstss.stshst.hhhhlsulhusAsllhlsslsshsshtppppRchhp........thsshussYsuLPss-.......h.p.sp.Dspss--phs.tppt..................................sspppGSGap	............................................................................................................................................................................................................................................................................................................................................................ss..th+tsph+h.s.cu.LFuPG-TFsh.splhu.htDp.tsashslsWhhhcs.sspCh.hhlYEsClYHPphPECLpPsD.ssCuhoS..hsphlAhRsYusCS.h......stC....h-AahE.l.................pssssptuGLYl..........hVh...............t.t......tsh.p..hP.h..................s...tst.st.........st.h.hhhhhh.s.hhhhh.hhhh.hhhhhhphtpct..t................................t.hY.h..tl....s..c......................................................................................................................................	0	15	17	21
+2898	PF01688	Herpes_gI		Alphaherpesvirus glycoprotein I	Bashton M, Bateman A	anon	Pfam-B_1222 (release 4.1)	Domain	This family consists of glycoprotein I form various members of the  alphaherpesvirinae these include herpesvirus, varicella-zoster virus and pseudorabies virus. Glycoprotein I (gI) is important during natural  infection, mutants lacking gI produce smaller lesions at the site of infection and show reduced neuronal spread [1]. gI forms a heterodimeric complex with gE; this complex displays Fc receptor activity (binds to  the Fc region of immunoglobulin) [1]. Glycoproteins are also important  in the production of virus-neutralising antibodies and cell mediated  immunity [2]. The alphaherpesvirinae have a dsDNA gnome and have no RNA stage during viral replication.	20.30	20.30	20.30	21.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.86	0.71	-5.11	13	161	2012-10-03 02:52:13	2003-04-07 12:59:11	12	1	49	0	0	151	0	161.00	44	44.88	CHANGED	splLhsllLhulhls...upulVaRGspVSLhssossss.ulhP...s-sslslhGcLlFlscQhPsss.YsGTlELl+as.s.spCapllpshpYsuCPRlpssAFpuC+ppcshp.s.stsplpsslcstsLLpIspPpssDuGlYhLRVplss.sssuDlFslslhlh	........p.LtuLllluLals.....usuLVhRGsoVSLsosS.lsA.AlsP.............hl--DLhlhGcLhFlGsQlP+oshYsGsVELhHYshu.p+C.RVVaVlohouC............PRpsAsAFshCRsscstH.oPAYssLphslsppsLLRlppsshc.AGlYVLRVhVss.AssAulFsLuhsl.h....	0	0	0	0
+2899	PF01528	Herpes_glycop		Herpesvirus glycoprotein M	Bateman A	anon	Pfam-B_929 (release 4.0)	Family	The herpesvirus glycoprotein M (gM) is an integral membrane protein predicted to contain 8 transmembrane segments [2]. Glycoprotein M is not essential for viral replication [1].	25.00	25.00	31.70	31.50	23.20	22.50	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.21	0.70	-5.76	30	163	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	92	0	0	141	0	329.60	26	92.25	CHANGED	MpsS+sDphth+hWhhplssaslhalssslssluAsFPsl.GFPCaasslVDYushNho......stNttptlTP.......sLFL-ssphhsYlhhohllhhssslYYlluultlhpt++.tssshsshps...lshlGossslahulLphWTlQlFlhsLSaKhlhLAAFsYslHFhh.shastshlophss.hthtpthpsl.c.sshLcpllhph+slhsNlhhshlulphllhuLohthulGNSFalhlucslhuulslFhlLsllahllsEhhLs+Yl+h.hGaalGsllusshLhhPll+Y-shF.......suplpsslslslullsllslshhllRllRhhhtp+pcpscYhslspsst......phc..hp.................................hp.s.csshhpp-ss	..........spsDphsh+hWshplshhslshlshsshhlhAsh.th.GaPCaassllsYtthNho.......shshhthhsP........LaL-s.phhsahhhshllhhhhhhYhllusltlhhp+c.pshphpthtp...h.hhus.solhhuhlphWhhQlhlhhLua+h..LuuhsYhlHFhhhshassthsoph.s...h.pthhtl.c.pstLcthl..h+slhsNlh.hhluhphhhhulshthhhuNsFhhtssphlhsshshFhllslhhhllhEhlls+Yl+h.hGhalGshhuhshlhhsshcYtshh.......ssshppsltsslullsllslhhhllRhlRhahh++p.+pscahshspsst.....ppht.h.t............................................ppps..s.........................	1	0	0	0
+2900	PF01537	Herpes_glycop_D		Herpesvirus glycoprotein D/GG/GX domain	Bashton M, Bateman A	anon	Pfam-B_603 (release 4.0)	Domain	This domain is found in several Herpes viruses glycoproteins. This is a family includes glycoprotein-D (gD or gIV) which is common to herpes simplex virus types 1 and 2, as well as equine herpes, bovine herpes and Marek's disease virus. Glycoprotein-D has been found on the viral envelope and the plasma membrane of infected cells. and gD immunisation can produce an immune response to bovine herpes virus (BHV-1). This response is stronger than that of the other major glycoproteins gB (gI) and gC (gIII) in BHV-1.  Glycoprotein G (gG)is one of the seven external glycoproteins of HSV1 and HSV2. This family also contains the glycoprotein GX, (gX), initially identified in Pseudorabies virus.	19.90	19.90	21.60	26.50	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.91	0.71	-4.17	22	286	2012-10-03 02:52:13	2003-04-07 12:59:11	12	2	62	13	0	265	0	111.50	34	26.10	CHANGED	lthst.s.cuCplslLts.sshs.thppt.........asAoluWahhhss.......CthPlhhR-YhsCssst..u..sCsthShshhps..shssauhlsts....LlhsPuhhsuGpYhh.lhls.sphhsuclhl	......h........tsCthllLtsssps..hh.sus.............YsApVsWa+lspu.......CtpPIhlhpYssCpsscs.u..sCs.thThshhss..s.spauhlsss....Lhhsss..suGpahh.ltls.s.hhhsphhl..	0	0	0	0
+2901	PF02489	Herpes_glycop_H		Herpesvirus glycoprotein H	Mian N, Bateman A	anon	Pfam-B_1142 (release 5.4)	Family	Herpesvirus glycoprotein H (gH) is a virion associated envelope glycoprotein [2]. Complex formation between gH and gL has been demonstrated in both virions and infected cells [1].	20.00	20.00	20.30	24.80	17.60	19.50	hmmbuild  -o /dev/null HMM SEED	657	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.97	0.70	-6.52	30	314	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	106	20	0	262	0	524.70	23	85.33	CHANGED	hssphhcpLaspsslsEsLtshhp+hpphapss....sshphsst.s.ssssssspsspsls.spshphssh...h.s.h..lps.......pplhp.ha..pp.shhhps....pslhashcstshthslth....sspsplsstlTpsFhhlolp........sp.pslshlFGpspclsslKu.hshp.shthspsspasLlllsshps.hspt.h.hhp.shtchhhphsphshtthh.pplpshhhth..hpstCp.ts.hs.pphhphhFphslshFhhscsh..ttsphlslspllcphspLphlpchhppCassh...................htshphs.........s..lpphusstltshshpph...tphshtppphhlpthhhs..spph..lssptlptltpllpslYppashsh......L..ssssRchLahhhtllp..................spohpssphthhalltTSMCostElup........hsphhupscshslhchFSPChhSLRhDhop-+Ltp.hspss..................s..phspsssshhshLcshcts.shphhstl.pCls.....scshhl..lPlsshT.YVISsch.lspGhsYsVosshlssshhlosl...pssCphs.ssttssppIPslhNlo...pppC.saCs.SsllpYDEssGlpshhYIsspplpppLhsstsshh.ssN.+sH.....YLlLhsNGTVlElpuhhppc..shshlhlllhhluhhlulalLY+lh	.......................................................................h..............h...h.................................................................t....h..........thht.hh....t..hhh.pt.............hshhashth.sh.h.hhhh......tpthhhhhhhs.sFhhlslp........sp...h.hhhs.....h.....hps.h..t....s.h..ts.paplhlls.h.p...ph..hhh..shht.h.p....t..h.h....t.hphhhh.....h....tt.st.........hhphhhthshshFhhspt....tst.hslsphlph.ttlh.ltp.hh.hp.shtth....................h.lh..................p....h.ph.th..hht.s.ht..........h..h.thhhhhhh......tp.......hst.hhp.......htphh.thapphhh.h......L.........ss..RptLhhh.thlh.......................t.tpthpthhlh.ouhCs..chst............hhph.tp.p...l.chaoPCh.uhRhDhs.phhh....h.tts.......................hstts.thhshlp...t...h....p.p...hhthh..sth...pC...........sp.hhh..lsls.p.hs.Yllopph.h.pGhsY.lsss.ltpslhlohl...pssCp..t.p..hp.shplshh..Nhs.....tC..hCt.ushhpYspstsl.shhhlps.p....h....h....ss......hsp...hh.s.sscsH........hLhLh.NGTVlclhsh.hct..shphhhlshhhlushlslhhlath........	0	0	0	0
+2902	PF02689	Herpes_Helicase		Helicase	Bashton M, Bateman A	anon	Pfam-B_607 (release 5.5)	Family	This family consists of Helicases from the Herpes viruses. Helicases are responsible for the unwinding of DNA and are essential for replication and completion of the viral life cycle.	19.00	19.00	19.00	19.00	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	819	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.46	0.70	-6.80	15	968	2012-10-05 12:31:08	2003-04-07 12:59:11	9	38	270	0	294	964	161	251.50	33	46.34	CHANGED	schs...........................sphhLNhTStsclc.IVc+I+pLSp...tsspsPp.hsWFcshh-sEsshsh.h.........................................LPFusYLITGTAGAGKSTSIQsLspsLDClITGATsVAAQNLSspLstsh..salsTIFpsFGF+SpHlshp..........Rh.hstsss.soIcclQ+pDLshYWsVlsDIsc+hhpt.................cphtthsshohsuhushscsuhPsLscSNlIVIDEAGlLu+HILTAVVFhaWFaNAhhcTPhYcsGtlPCIVCVGSPTQTDAlpSsFsHppQ+pcV+pu-NlLohLIsNcsLpcYsclscNWAlFINNKRCsDsEFGcLLKsLEYGLPlo-EhhcYVDRFVVPcuhIpNPsphsGWTRLFlSHpEVKuYhupLHspLcls...........tssphslFThPlhshVpscsF--Y...KctlspPuLol-cWLppNhsRLoNYSQFtDQDhusspsEh..........s-pu.....................................hllThclpYV+NSploVTuKsKKslhGFoGTacpFtplLcsDuFl-spuc-psEYAYsFLSsLLauGMYsFYsahhssu.st....phhpcLsplslP.ht.....pshsusss.....................................s-h.D-s...............shLspps...DhFYppYphsPssoohshsElhuhYpslKslFlsRaslhpchFGspFspuPFsTas.sNlsh+sstpFsSs.c.hsGLLuaAsss-oYTLpGYTassVhhhsp-tpp......hhphhhppchPplVl+DppGFlSlLcsNlo+hsEol-s.pplchsossDYGISSKLAMTIsKSQGLSL-KVAlCFuss.pNL+huplYVAhSRsssucaLhMNhNPLRpphE...csshlSpHIlpAL+sssThLVY	......................................................................................................................................hht............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lt.p....h..AMTIsKSQG.SLc+.Vulshsps...shphuphYVAhS..RsTS.p........c.hL.+...h.............................................................................................................................................................	0	106	204	254
+2903	PF03324	Herpes_HEPA		Herpesvirus DNA helicase/primase complex associated protein	Mifsud W, Fenech M	anon	Pfam-B_3676 (release 6.5) & Pfam-B_4951 (release 14.0)	Family	This family includes  HSV UL8, EHV-1 54, VZV 52 AND HCMV 102.	21.10	21.10	36.20	34.40	20.30	17.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.96	0.72	-3.95	32	154	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	84	0	0	151	0	93.30	30	12.85	CHANGED	hslpDlFpsp-hsltlts........t.lpl+llsPh.sFchlhssspsh.shuLhshaptlaspla.u....shpulhPlasYlsPphh.pGss..a..sl.....hFPGFPhl	............s.huDlFplp-sslh.ps.............t.hslRllhPt.hachhlosspsh..hsLhuhapphassla.u......shsulsPlasYLGP-h..pGssh.a.......sl......hFPGaPsl..	0	0	0	0
+2904	PF03585	Herpes_ICP4_C		Herpesvirus ICP4-like protein C-terminal region	Bateman A	anon	Pfam-B_1422 (release 7.0)	Family	The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection.  ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer.  ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region [1].	25.00	25.00	34.00	29.80	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.49	0.70	-5.76	13	161	2009-09-11 08:11:53	2003-04-07 12:59:11	9	3	37	0	0	135	0	321.00	49	27.44	CHANGED	GGFRRhPsGssHTP.........sPucushpAYCsPcslucLsDaPLFPpsWRsALsFDPpALApIAARssussst.....................spthGshsussPLRRRsAWM+.QIsDPEDV+VVVLYsPLPGEcLsssssss...s..ttPpWsspR.GGLShLLAALuNR.LCsP-opAWAGNWoGsPDlSuLsAQGVLLLSTcDLAFAGAVEYLshchuuA+RRLIVlDTVssE-WPpDGPA.lSphHlYlRsslpPsuQCsVRWP...sspcLuRAVLsSuclFGPusFARl.EAAFARLYPsssPLRLCRuuNVRYsVcTRhGscTsVPlsPR-YRptVLPuhDGppchstQstuhshGsPDFl-GpAaSHRAAsRWGLGAPLRPVYLupGR+uutu..uPct..lPtslRsFCtpALLEPDs-ApPlVLpsspuss.............hsssPultWssuhGptsT.l	.......uuaRp.P.G..hs..........hPsttshtAYC.sthhhtLh-..hhP..Wp.sL.asPtAhAplAthtss...................................sst.LRthsAWMp.Q..sP-DVpllllYsPLstEcl.s....s..........asst+.GGLShlLAALusR.lChPsotAWAGsWTu...PDlusLst...pGVLlLSTpDLuaAGAVEaLt.hh.usucR+LlVlDsVs.pcW.PtDGPA.lSp...h...HlYlRsshpPsuQss..VRWP...sscsLtRuVhsSucsFGPusFARl.EsAaApLYPst.PLpLCRGGNVtYpVpTRhs..o.VPhsPhtYhthVh.s...ptt............tsDF.tttuhSHRAst+WGLsA.LRPlal..u+.shh...tPt...h...hp.hCttslL.PDstA.PlVl.....st..s......................stl.W..t.......................................	0	0	0	0
+2905	PF03584	Herpes_ICP4_N		Herpesvirus ICP4-like protein N-terminal region	Bateman A	anon	Pfam-B_1422 (release 7.0)	Family	The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection.  ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer.  ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerisation [1].	25.00	25.00	102.60	102.30	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.13	0.71	-4.76	14	132	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	38	0	0	132	0	174.20	51	12.23	CHANGED	sssGEsWPsusPPPtGRVhaGusG-pRpGLWDsP-VcpAttRapAusuPsPVaVPEhGDssKQYpALVchlas..sp-s..huWLQssKLousDptLschC......p+hhsus+upGo.......hlTGoVssslPHlGcAMAsscsLWALPHsAAuVAMSRRYD+sQKsFlLpSLRRAYAsMAaPtsus	.hssGEPWPGusPPPsGRVhaGssG-oRpGLW-sPplcpAttRacAustPssValPEhGDsucQYctLlchlYs.Pst-s..huWLQNPKLossDtsLsphC.......+l..hssuRupGo.......hlTGSVApslPHlGcAMAsGcshWALPHAAAAVAMSRRYDRsQKsFlLpSLRRAaAshsaPcsus......	0	0	0	0
+2906	PF03361	Herpes_IE2_3		Herpes virus intermediate/early protein 2/3	Mifsud W, Fenech M	anon	Pfam-B_2178 (release 6.6)	Family	These viral sequences are similar to UL117 protein of human  and chimpanzee cytomegalovirus, and to intermediate/early  proteins 2 and 3 of certain herpes viruses. UL117 is thought  to be a glycoprotein that is expressed at early and late times after infection [1]. This region is close to the C-terminus of the protein and may be a transmembrane region [1].	25.00	25.00	48.90	44.20	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.74	0.71	-4.91	14	91	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	27	0	0	96	0	159.10	35	28.34	CHANGED	Phpshs.+plhpcshclC+phpspspsIhhhaTRoppVtpslcsh+pcLhphsNlolSsPFphpHT.PhhHs.cssppsschpppGsppsW-hpcsp.s....HshssRpSDh+ohhIpAATPhDFlsAs+lClphupcaPKplslRlsol.psuht...LPIYssssc.	.....Phphssh+plh-Esh+hC+shpspspsIhhlaTRspplcstlcsl+scLhphsNlslSssFhhpHT.shsHsPcsuppTtchpppusptsWshcc.p.s.....+phssRpSDh+sMhlpAATPhDLlsAlpLClslspKaP+plslRlhsh.psuhhh..LPIYpphsc.h.................	0	0	0	0
+2908	PF03363	Herpes_LP		Herpesvirus leader protein	Mifsud W	anon	Pfam-B_1664 (release 6.6)	Family	\N	25.00	25.00	29.70	29.60	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.91	0.71	-11.96	0.71	-4.69	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	7	0	0	46	0	111.30	67	134.18	CHANGED	RGD.SEuPGPoRPGPPGlGPEGPhGQLLRR+RssSPTtGs.E.P+RVRRRVhlppE-tsVSGsPotPRGD.SEuPGPoRPGPPGlGPEGPhGQLLRR+RssSPTtGs.E.P+RVRRRVhlppE-tsVSGsPsuPptPh.Q................PsApShREWLuRsspRssspPVsTh.RRRVYIEEEEE.	.....hGD.SEssGPsRPGPPGlGPEGPhGQLLRR+RssSPTtGs.E.P+RVRRRVLVQQEEEVVSGSPS.PRGDpSEuPGPoRPGPPGlGPEGPhGQLLRR+RssSPTpGGQE...P+RVRRRVLlppE-.psVSGsPs...................................................	0	0	0	0
+2909	PF03122	Herpes_MCP		Herpes virus major capsid protein	Mifsud W	anon	Pfam-B_600 (release 6.5)	Family	This family represents the major capsid protein (MCP) of herpes viruses. The capsid shell consists of 150 MCP hexamers and 12 MCP pentamers. One pentamer is found at each of the 12 apices of the icosahedral shell, and the hexamers form the edges and 20 faces [1].	25.00	25.00	40.20	40.10	14.90	14.40	hmmbuild  -o /dev/null HMM SEED	1354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.16	0.69	-14.22	0.69	-7.25	32	190	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	98	2	0	182	0	1168.50	38	98.62	CHANGED	stls.ssuslLspI+.outctLFcsFchhhG-DspcYslpF-sLLGsYCNslpaV+FLETuLulAClss.cF.DLphMs-G+lQFclphPpIA+uss+sss+.sphhlsKtscK+slossFplustsLplLptshps.T.l-phhplpAlppls+slphslDAhERGhlDphLpVLL+KAPPhhlLpsL.pcshhspRshs+lsRuslluphKp+lhpshFFLs+sp......+phlhphLs-hlsus.ppSVhpstsTaos.ssGc.lsGVllTTssVhppLlshlsp.lsctssssPssYGpaVlsGpNLVTAlshG+sh+sF-phsp+llshtps....tsp.p.........psp.spsplsssllplG-+hVhLEuLc.RVYpsTpssaPLtppl-lTFaFPlGLahP...s+YoT.uuplps.....tssscp..PspsaFhNKDphlhplsapsALtTlCHPphhssssslpuLptt.h....ssstch..............t.phauhthpp..sthslhphhhpFac...s+h.sshsshshcsphos-pFh+PsN..hLthELHPhFDFaht.tssshs............shtAohRlhsGNIP.PLuPssF+-uRGtQlts..shppl..ssuTlphlpsThpDssYPhlhYllEAhIHGsEctFshhhpLlupCIpoYWpsstpLAFlNSFtMltaIssaLGsGtlsc-sauhYRclhuclpsLcpsltchsh.s-slss.pshtthssuLhDssLLPPhlac..hs.ll.csp......Rssplpsssp.hsss...sc.ttlshh.+hpshhsctsshhss.ssss..h.hh.t.........-hhlLpKIaYYsllPAhopG+sCuhGVcacplhhsL...pss......................hss-....hsss-cs.hs............pLhssslpslhpsucls.sssshl.tpLttshhpssppTpslclpsshDsupppussp.shpshpssLaNGhhhhuhscpspthh.psaFYPlPhpthausP.....tlssshssplpshlpchPt.........lPshLuuEYhpahRsPhspYu....spstss.solo.sLhuhahKLSPluhhtQh+ptlHPGFAhTVVRpDcFhsEplLaupRASpShFlGpPpVs++E.+ssulsFcloQshuslDhGLGYoushssAplpslsTDMGspsQsLFtshsstsatss-lssalRptluspp..s.....sshshhshGthpsssssGltHGQhAsCEhIlTPVouDlsYFppPsNPRGRuus..lhusDs.sppsAcphhYDHopsDsAasaRuTsNPWASQ+sSLGDlLYNupa+pp..sssshYSPCtpFFoss-lhppN+sLh+LlsEYss..ussssousT-lQahsssGTcphlEcPCthhQEAaPhLsAScpALLcph..................hsspssp..........uEsHhupYLIc-suPlpthlh	..........hhsssuslLopIchuutcplF-.FphhhuD-sphYslpF-sLLGsYCNplphV+FLchuLulAshss.+F.-LshhspG+l.Fclp.PhIApssshsssp.hp.hhsKhhc++slshsFplustslshLptph.s.T.lsthhplcAlpplhRslpsshDuhERGhhcphLplLLcKAPPh.hlL.sh.pc.h.st+hhs+ltRuslluphKpphhps.FhLs+st......+phl.thLschssus.p.Slhhsh.Tass.spGc.lsGVlVTTsslhppLlphlhp.lpcppsssPsoYGphVlsupNhVTAlshGpshtsh-phsp+llshppp....p.p.......t...tst.ppspltscllplG-+hVhLEuLc.RlYpsTps.hPL.tph-LTFhhPlGLa.P...cpYushsuclt......psssct..PpplaFhNKDphl.plshpsAltTlCHPshhsspssltshppt......ch..................t.p.hthhhtp...s.hshhphh.pFhp...tch.hspsp.hhcsphoscpFhpssN..pLhhELHPhFDFhht.tssph.............th.sT.RlhsGNlP.sLsPssF+-sRGhplt...thpth..t.uTlthlpsohpD.sYPtlhYll-uhIHGsccsFthhhpLlspCIpsYWpspphlAFlNsathlthIssaLGsGtlPppshshYRclluhlphltphltphsl.stplss.ps.tthsphlhD.tLlPPhlac......h.+st......csstl.sssps.ssht..hp.tths...Rhsshhhct..hhss..sst.................-.slhpKIaYYshlPAhops+sCshGlchcplhssl...psh......................lsP-...hhss--s.hs.......................................pLlsshlpshhpsucls.sssshh.hpL.hhhhphsEpTpsl.spus.Dsutppussp.thphhptsLasGhhhhu..ch......tpaFhPlPhpthauss.....shssshsstl+phhpphP..........lPshlutpYashhRpPhspas....tps.ss.pul...sLhuhaaKlSPluhhtQh+stlHPGFAhTVVRpDpF.s-plLaup+ASpuhhlGp.pVs+c-.pshussFplTQshusVDhGlGYoussssAtlppshTDMGstsQsLahshss.shhsspsstalRptssstp.......ssshsh.sFGshpstp.suh.HGQtAsCEhIhTPVosDlsYF+pPsNPRGRAus..hhusD..pptsspthhYDHspsD.uhsatuTsNPWASQchShGDlLYNsta+.p..tssshYSPChpFFsss-lhsps+sL.+llsEhss..uhsshsuso-hQahps.GopphlEpPCthhQEAaPhhsuos.ALLcsh....................hpspstt..........sEsHhupYlIt-suPlpthh.......................	0	0	0	0
+2910	PF04797	Herpes_ORF11		Herpesvirus dUTPase protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_6280 (release 7.5)	Family	This family of proteins are found in Herpesvirus proteins.  This family includes proteins called ORF10 and ORF11 amongst others. However, these proteins seem to be related to other dUTPases Pfam:PF00692 suggesting that these proteins are also dUTPases (Bateman A pers. obs.).	20.10	20.10	20.20	21.30	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.85	0.70	-6.01	23	85	2012-10-03 01:18:03	2003-04-07 12:59:11	8	1	32	0	1	104	1	307.40	23	75.33	CHANGED	hshshWsssltsshlpl.oNppslpltsspsp......LPhsssh.thLtcphsuFuhssolhshp.hspsshhlhus....pssplclhPtslhcsppslslplpsstps.lstGsLphhllslshlphstlhhhhhsspss..h..sssssptusthsspp.splplsGpsspossps.h.hhhsppshsFhc..........................................................................shs+lpstpstsshlpshphucshh+lslp..p.ptsttlphph.lpsshohh.ps.l..........sFpas..hthshptsp...l..lYsssshhlsPspshpVchsspYtsstssttss..hhlsspsssspahlps...s.WhPtsshplslpNsostPlplpsustluhAlFlh.....ptssssshschhhpptosslphsusl	...........................................................................................Wphpl..shhhh..Nh..h.h..tp.t......LPhs.s....lhpthssashs.sh.t......ht.shhhhhst.....ss.h.lhP.hl.p.pt.l.lhlps.....h..tthhhhlh.lp.h..pth.hhh..............sth.p.hp.hss...s.h.ltG..h.s.....p.tp...hh.s.h...hhp............................................................................sphp.......p.h..........hstthh+htht.....t.s..h.h...htsh........l..........sh..s.....s...st....hhslYscpslsIsPtcotpVhasstYhp.usstphsh..hllstpssps..c..hhlcP...slWhPussstlsVhNsSspslsIsssTplApAlFh...........tt...p.hht..sttl.hst.....................	0	1	1	1
+2911	PF02399	Herpes_ori_bp		Origin of replication binding protein	Mian N, Bateman A	anon	Pfam-B_1518 (release 5.4)	Family	This Pfam family represents the herpesvirus origin of replication binding protein, probably involved in DNA replication.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	824	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.50	0.70	-6.59	13	207	2012-10-05 12:31:08	2003-04-07 12:59:11	10	9	101	0	8	215	11	389.30	22	60.09	CHANGED	sYsSSsSLARhLYGsDLh-hlh+s..+P.uVolEpQscuPVsFPsPhssssRsVpVVRAPMGSGKTTALlcWLppsLt.usDtSVLVVSCRRSFTpTLtcRhscuGLs....................................GFsTYhsussYlMsst.a+RLlVQlESLHRVspsLLss..YDlLlLDEVMSTluQLYSPTMp.+LscVDulLhpLLRpCP+IlAMDATlNuQLVDhLutLRG-cslHVlls-YAosGFSpRpChlLcsLGs-sLtuslp.....tt.stpst......tsst...stt....psss.....FFucLptRLtuGcNlClFSSTloFSElsARFCtpF..TcuVLlLNSpcshs.DVssWupYRVVIYTTVVTVGLSFDssHFHSMFAYVKPhptGPDMVSVYQSLGRVRoLhcNElhlYhDuSGARu-PlFTPMLLNHVlussusWPspFsplTNhLCpsF+t+Cssua....ttucshhLFsRFKYKHhFERCTLssluDSlNILHsLLssNplpVph-Gsp...slss...csFssFLpsL+tDAhsup+cl+pLR................tsssshshssplh-s-...sVusFhcKY..LRssVss..p-lhpLlpsLus.PlsRtpFlNlslLc...AC.........htlPsAlcSpcVFp+lYs+YAoGslP.........llu..sGtlEhssLssshNssspW.-La+LCsphAcsLslsstpssss.s........lssssllpshsschsp.htphlLElh+CslT-uphhsccsVptstshLuGttstpht..shSptcH...AlulF+lhWcplFGs+lsKSspTFPGssRVKNL+KpEItuLLDuhslDRous+THRpLYsLLMpp+ppFpp.sRY+LRsPsWuchlp.p..........-h.....LEsuLuclsspsWPpspG	..........................................................................................................h....hh+ushusGKT..h.ht.hhtt...................ph...hhl.......shR.sh.tph.tph.................thh..h.p.........pt......ht.........tplhhplpSl.h+h......t.......................h..-..llllDEl.p.hhtp.h.h.o...hh...p...p.....ht..s.....t.hhh.hltts.pllhhDAshst.hhphh...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	5	7
+2912	PF03325	Herpes_PAP		Herpesvirus polymerase accessory protein	Mifsud W	anon	Pfam-B_3097 (release 6.5)	Family	The same proteins are also known as polymerase processivity factors.	25.00	25.00	331.80	74.80	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.82	0.70	-4.86	6	52	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	27	2	0	48	0	243.10	52	71.12	CHANGED	MsAsDasMEFSSsCVHGQ-lVRESGcSAlRVDLDaSVVuELLKWIuPpTRsKRssK+ssssssTsQIlVHuNPPoIKF.LsssSELEFTAosRVuFH-VKNMRlsVQhKNLaQALsNCAVTKLuCoLRllo-H-shLaluSKNuhFoVENFLTEEPF.RuDstF-Rthtppps.............slsNust.pss...........s-.h............s+Kt-R......ssRp.stt.........-H..ttG.upcsKYE.QHKITSYhVsKsuuuuG........-R..osaFNDsKEESDSEDSVoFEasPNoKKQKCu	.....MsAPDaNMEFSSsCVHsQDl.lREotsSAs+VDLDauVVu-Ll+WIuPphRsKRNsKKtsssouTVQIhlHusPPslKF.Ls...ssSELEFTAsNRVuFHtVKNhRlsVQhKNhaQsLhNCAVTKLsCTLRlhT-H-ThLaVuS+Nu.FslENFLoEEPF.RuDs.....F-+..htt.................s.sNusshpss..ssG.D.thhs-.h................s+KH-R......ssRKhsttGs..........tDH..ttG.upcpKY-.QHKITSahsoKGusuuG........-R...usYFNDsKEESDS-DSVoFEas..PNoKKQKCs....	0	0	0	0
+2913	PF04846	Herpes_pp38		Herpesvirus pp38 phosphoprotein	Mifsud W	anon	Pfam-B_4545 (release 7.6)	Family	This protein represents a conserved region found in most herpesvirus pp38 phosphoproteins.	21.40	21.40	21.50	21.60	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.88	0.72	-4.66	5	34	2009-09-11 14:05:08	2003-04-07 12:59:11	8	1	9	0	0	24	0	61.50	59	25.88	CHANGED	ENsshRSthllsLlhSAKoLVlGSCMuFhAGsLIG+usclcoospssssLhhAFCAGhlssGl	.....ENATMRShMllTLIsSAKSLlLGSCMSFFAGhLVGRouc.V+TPlWDTVsLLMAFCAGllVGGV.......	1	0	0	0
+2914	PF04637	Herpes_pp85		Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)	Mifsud W	anon	Pfam-B_5418 (release 7.5)	Family	This family includes UL25 proteins from HCMV, as well as U14 proteins from HHV 6 and HHV7. These 85 kD phosphoproteins appear to act as structural antigens, but their precise function is otherwise unknown.	18.40	18.40	19.60	20.60	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.56	0.70	-6.20	13	77	2009-09-11 05:49:28	2003-04-07 12:59:11	7	1	26	0	1	71	0	464.20	29	71.87	CHANGED	lD-pLNFhPslloscch+alpcsLspu.ssstVuhlNuslPMPsYsLEuLlcshl+pphs+s+slhcslI+lslhlN+YhsupchLcchpsthcshhsssp.hcRLcpuLppLh.pstpssssPhslhhtLscpsloputappsLcpLpclhcshshc.sschcs.pYppLpsaNhLapsPhaTopEAl-lYucNLpcLTpppscs..hcLloshpp..stsh-clLNDlhFLLSltphlhpapcpLptLRsaIhhplssLs-shYhsYsQlP-hRpsahsLsctltshhspsp..s-t.....FpshltsLhphl+plpcAsValsPsYl+ttlhth..hh.p.pps....ts.Dps.-tpp.....................h-.-ssushs.shhhspNshsss-lFRs.Pcss.phhtc..hhcpphopplhhsspssploscphplpphsplhhcuuuppsplsPcphhchh.........t......pst.t..t..husVphpsh.................p..pstp.s....uspssshssspPhusstp.p......tst	................................................................ls-pLsFpsslluspchcalttsLppu.ssstVshlNpslPMPsasL-uLl-shl+pthh+s+slhc.lIphslllNaYhsupchL+chpsthcshhsssp.hcRltptLppl..pstpspsss.slhhhlucts.lTtGtappsLcplcplhcshshptusctps.hYppLpsaNlLFpsPhaToptAlpLYtcNLp..cloppppcs..lcLLoshch..p.s.-csLNDhhFLLolpphlhpapcsLchLRsalhpphpsLs-hlYhsYsQsP.p.hRpsahpLsctlththspsp...D......hpshhtslhpFl+plpptslalCPsYlphslhtl.................h.Dps..........................ht.-.ss..u.s.hhstp.hsssslF+s.Pctspp.htc..hhpp..sh.hhhshpptphsspph.lpphhphhhpusph.stlsPcph.chh..p.hs.s.....................l..hsh.................ps.....ss....tt..t......sshP.p.h......ps................................................................	2	0	0	1
+2915	PF03326	Herpes_TAF50		Herpesvirus transcription activation factor (transactivator)	Mifsud W	anon	Pfam-B_3658 (release 6.5)	Family	This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.	19.70	19.70	19.80	20.10	18.10	19.50	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.51	0.70	-5.55	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	25	0	1	68	0	284.80	34	89.77	CHANGED	LFRN.Ks+pRupsuss.ssCAphuppll+alhERllhsTD+hFlsAsCSGVslP.sLApslaclhp-sRsKChuuWRpLussRRslMslucpllssYN.sLcssGhlSsch+AFhKLsFPshsLpplhpPlhthspGthsspshhshpG..up++RsspsshaSthsstspaslP-sLltshs-....sGLlssstsDlSsLLpNPppILp....hs.lupFpssssps..slPpsho.lssssoussPtp...sFtssasuso.........pssptpsostshustuspS.....sossptsplssS.ssts.sppshtuplshsosstPu......phsh.t..pssthP...........Pst.hsttp.p.........hssstlppshtsussppP..................tspPsusupps.sssush.pshss.ssossshpsssphsPshsp.ptpsssshps..............hsusshsspssp...........hsPuttp...........tDsslhshlppshssph-huuPss....hhhsshsp-l.p.sssPshcsspsstpt.-phsslssP	........................................................................................................................................................................................................................................................................pShLsauss-lShlL.pcsush.c...hsctsuPt..supThpP..ulPpspSchcPSPousssustp.spspstspuT.........ssspscssssPpuPpusop.....sossQcsp.sCS..s.ssusspssh..haspQsusshsu......plstsssssshshP...............................Pspspshppsshs................................................................................................................................................................................................................................................................................................	0	0	0	1
+2916	PF04843	Herpes_teg_N		Herpesvirus tegument protein, N-terminal conserved region	Mifsud W	anon	Pfam-B_3992 (release 7.6)	Family	\N	25.00	25.00	25.10	26.60	22.80	21.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.11	0.71	-4.84	23	211	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	85	0	16	203	0	173.50	32	6.75	CHANGED	Ss.sQuc.s+aGstAGsQClSNClhaLpssYhsG....ssllspcsLDslLcpGuclDthhcpssh......hs.spastls-lPshlpos...............hGpsshhhSp.h.Ghlpsps.s.pt.hlt.lchlhpsphpphsp.YhlhhssshutAlllp.ssphalFDPHspspt...ssAAVlsspsss-llsYl	....psQhs.schGPsu.GspClpsSlsFLphsahtG...hss.sLos-slDusLpEGuphspthpptsp.........sshsths-LPshlph................aGcssaa.stPhtG.hhp.Tpsss.pt........Fhttsatt+t.s.Y..sll..Tlssh....uhulhpp....scthalFDPHupsph.......stAhhspsphs-lh.al..........................	0	8	8	16
+2917	PF04523	Herpes_U30		Herpes virus tegument protein U30	Kerrison ND	anon	DOMO:DM04370;	Family	This family is named after the human herpesvirus protein, but has been characterised in cytomegalovirus as UL47. Cytomegalovirus UL47 is a component of the tegument, which is a protein layer surrounding the viral capsid. UL47 co-precipitates with UL48 and UL69 tegument proteins, and the major capsid protein UL86.  A UL47-containing complex is thought to be involved in the release of viral DNA from the disassembling virus particle [1].	25.00	25.00	30.40	70.20	24.40	22.70	hmmbuild  -o /dev/null HMM SEED	887	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.43	0.70	-7.09	18	68	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	48	0	0	67	0	893.00	26	92.53	CHANGED	LpclhppLpssoss.hspL+hLhclElsslslpsl.ossplppFLNpLsphsG.tahsFIppahVFYLL+tuThsspphsht..stcplhphLpph............pphsssstsssssshLsNpplLsplppalsphp.....................................................................shpshppssssspsltshRsVEEllcthapshaphhhtshhh.pht.sssohL-pWLhhhatpshh.........tsshsslpshAppLlsp.............ctc.lFsshsssstshlshPhAcpputtIaplFsps..spsssstssPlLuhssspLs.plssphhFhYcallEuLhpspsY..........ssspstlEpFl..............................................scshshhssluspl.pssop...ppphohsslpphpttLhphGLoccsCpsatphlhhp....s....tssssshcthsphhphlspLshhuahFatCLtpaSPTulhtpch+.ILcpspuhtssppt.....................phsh.Ws..hhslhphFhspsPppphpphspulo.sthh+shhahshpcpWshhhhshp...........ttssssshsstsssopp-lp+aCctlph.......G-s..sY.-s..sllppPhFsptFlcphllPplptILssphpctRuhhplRWLllauus.cs..PpLhpl++sLshlYhtlh-Ihctst.............................................uuhtslhDhhp-lhstlpphs.........ssh..ohsssLLppLahtpassshpphlss.lpcalscspsllpshhshsplusslspsphphsspstpVplshts....ppshpl..............slssFpsslpslpppsp-hhstlsphspplpshhhcLh.sllpclpplppH.l.....shs..p.shpplpcthhcshp+hpsltsplssosshph.s+pFstLapssLlslthlpclLshs..cppssspshl-uhs.shsptssss.s........LsccslptLpchhsphh....psspsss...sslc+paosshchsthsls	..........hpclhcpL+tpsss.tttLphl.plEluulsspsl.oustlppFLstLsp.sG.haFsFl+ppsVFYLLppuTlpssppsL...sAcplhppLpch............tpttssssstsp..shLsNtp..sLsthpphlpplppl...................................................................shpplppssstspshsNCRsVsELl-hhYpphhtahhp....h.a.hthppssDopLDplLhhtahashh...........pussssLts.Fpphlcp.....................ptc.hhsshssoshsssptPsucphpshSa+lFstsltsp-ssshhaPllusshohLs..hluPcphFFasGllptLLpppsh..............t.hcph..L...............................................cthschhs.plspplhcsss....pp.hsltclhphhptLhphGLsccoCssYtpMlhhp.............s.......sspps.thls-htpplhpllassahFFhCL.hYSPTF.LFhp+++hILEppcuhlhus+p.....................phptlWsplshNlpphFssphsEc-Fpthscuso..phtRpaLY+clppKWGshhFshp...........ttsssssshsshcslTppDlh+hCthlpl.......u-s..sYsolhshspaPtFsshFhphhllPplppIhshs.sphpuhss.RLLhLhths.clLhPpphpLh+sLl.lYshhh.lhchDt.......................................................usF+slhDhlh-lhstlppls..........tssh..o.sscLLspLhspuhspsltsplsshlpchhpssts.lppalcasplChuLscspsphsp..c...shsVhl.lps.........phshpV..............shspFhpplcplhcpscpltpslptlspcltslhhRlt.plhp-spplspa.........stsp.shpphscshp+shp..+lpslpsplstshpp...sp+.NthhhsulhphhtlpclLspctlcppuhp.sls-Ahuhhppppuhsshs.s......hsp-shph..L+chhcshh.....pss.pss.....shhpphosst-pss.p...............................................	0	0	0	0
+2918	PF04541	Herpes_U34		Herpesvirus virion protein U34    	Kerrison ND	anon	DOMO:DM04381;	Family	The virion proteins in this family include membrane phosphoprotein-like proteins such as UL34, Epstein-Barr and R50, from dsDNA viruses, no RNA stage, Herpesvirales. The family Herpes_BFRF1, Pfam:PF05900, has been merged in.	25.00	25.00	31.60	30.90	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.31	0.70	-5.42	29	132	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	81	0	0	115	0	202.70	29	69.62	CHANGED	shtcphhschs......sllpRlhhlss.usLcsscssss...hspuss.shCshphp....sspsaslEYVh+h...WA.csps.....sPhhhlpNTGluVhlpsFhstPtss....hu.slsstcsNVhLpsscosuluLsDlpchKt.h..uhDhcshpuhlhhpsalp...spspLpFhhhGPcsssRspplLcpshttt....tsctptp.cpstsshpspsttsssts.sss	...........t........hh....slspRIhhlss.usL+ss-sp.....hspsss.uhCsh.hp....sspsaslEYlLph...Wt.cssp.....sPhhhhpNTGluVhlpsFhptPhss.....s.shs..stcpNV.LpsscolsloLsDl-clKt.h..shchsshpsplhhpsasp...sphpLpFhhhGP-ssu+hppLLcclhttt.....hsptptt..hppt.s.tsp..........hst......................	0	0	0	0
+2919	PF04533	Herpes_U44		Herpes virus U44 protein	Kerrison ND	anon	DOMO:DM04376;	Family	This is a family of proteins from dsDNA beta-herpesvirinae and gamma-herpesvirinae viruses. The function is not known, and the proteins are named variously as U44, BSRF1, UL71, and M71. The family BSRF1 has been merged into this.	25.00	25.00	28.90	28.90	23.60	22.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.38	0.70	-5.07	11	59	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	0	0	49	0	205.90	33	77.15	CHANGED	Mu..h.tWh.CCGl..h.FG+ssp.pYcpLs-s...tpss-Rh+tEI-hGLPP.GVplGDllpsppsppoL+QsYLLAV.....QoNpIT-aLcRFDusclPpuCpslVpsQIsKL+ulpslIWNsMlSlAlGslolD-uulpsLLsKpAs-ohuLhEMEKlATAlchD..sossWApEIssllsstssssts......sslhspspsphshs.h..s..................cstph..sst	...............h...................utshs.cYhhLpss...-sp.c-lpshl-.sass.GlssuDLhphs+-s-.slc..aLLtLh....QspphssaLc+ahusp..C.sHs+sssclEspK.pplhpsl-lhhLKLsVGEhsh.s.-.-uLchLL-KFusDQsoLsEhpKlhsLlcMD..ppossah.......................................................hptsstts.......................................................	0	0	0	0
+2920	PF04529	Herpes_U59		Herpesvirus U59 protein   	Kerrison ND	anon	DOMO:DM04374;	Family	The proteins in this family have no known function.  Cytomegalovirus UL88 is also a member of this family.	21.10	21.10	71.40	69.30	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.39	0.70	-5.62	8	35	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	27	0	0	27	0	390.30	40	96.13	CHANGED	PsssWpDuALlhsDGTVtEHchhNusLucLlRRplcs..-s--t....sVauSELulYloGRssRpuSsFSIYWpsHS-llYsLTGlTHCsKIsVECGph.........................................................................usDup..............plY-hP+laLlRspD.ussuPpcVsWstTsshWsp-VsIcsVp..p+sssARshsslh...................P-ltthhhPLLphtsc................................................s-.slFcE+VussYpRL...t.chssss+oppclLp+ClcLAutK+LLLlDGst.LENFFLspVCLYpLGEDs....luEEhlGhLtsRP-c.....uuuuFhLH+cshpsAssLAllLNslac+Q-tLPsl-p........RlDpsD.lssAl+cYYcpalsVphpsLuhApclLstFopphsstsuhshl..sttlslDusVSRpDllpVLRu	........................sstWpDuALlM.sDGTlhEHtFhNssLupLlRR.............hl.s..-t--p..........sVauSELuhasSGRhsRRuSsFSIYWpsHSDLlYALTGITHCsKIsVECGph.........................................................................ssDup..............chY-hPtlYLlRsp..D.ussuPpcVhWstT.sshWspDVsIpsVp..p+hsuARshsssh...................P-lttchhPhlp.hsc................................................s-oshFcp+VuusYpRL.....chsshs+sspclLp+CVpLAuuK+LLLlDssh.L-NaFLspVCLacLsEDp....huEEhlGhLts+s-s....tuuusFhLH+cshpsussLAllLNslacapctLPsl-p........Rl-psD.lssshRcYYcuassVpspslusApclLssao-phsshcuhshl..chhVshDusVoRccLltlLph..	0	0	0	0
+2921	PF03580	Herpes_UL14		Herpesvirus UL14-like protein	Bateman A	anon	Pfam-B_2982 (release 7.0)	Family	This is a family of Herpesvirus proteins including UL14. UL14 protein is a minor component of the virion tegument [2] and is expressed late in infection. UL14 protein can influence the intracellular localisation patterns of a number of proteins belonging to the capsid or the DNA encapsidation machinery [1].	25.00	25.00	68.00	67.80	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.73	0.71	-4.41	12	75	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	36	0	0	47	0	142.40	53	74.68	CHANGED	pRRcRhhLAEs....+hRtplYKpRTL-LlptGVsspDPtFltAFTuA+pAct-hctpl+SstRlpslcp+sptIpt+V-pQssh+tlLsspRRaLsscFhcpLDpsEDslh-pE-pLp-A....p..huss.st.ct....hsp---uLLspWhLpps	....p.tthRRRLAEs....HlRAclY+-pTLpLhREGVoTQDPcFVuAFMAAKAAHh-LEA+L+S+ARLEhhRQ+AssV+lRVEEQAARR-hLsuHRRYLcPuLuERLDAs-D+LADQEEpLEEA..sssh...st....t.......ht.tppsLLh.W.Ltt..........	0	0	0	0
+2922	PF04559	Herpes_UL17		Herpesvirus UL17 protein	Kerrison ND	anon	DOMO:DM04385;	Family	UL17 protein is required for DNA cleavage and packaging in herpes viruses. It has been shown to associate with immature B-type capsids [1], and is required for the the localisation of capsids and capsid proteins to the intranuclear sites where viral DNA is cleaved and packaged [2]. In the virion, UL17 is a component of the tegument, which is a protein layer surrounding the viral capsid [3].	25.00	25.00	25.80	25.40	22.10	22.80	hmmbuild  -o /dev/null HMM SEED	540	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.81	0.70	-5.92	36	169	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	90	0	0	150	0	507.20	22	95.08	CHANGED	M-sHltN-phh........sspsthllHl.llscssLpttslsh.......................spshhspspochpsssts.o..............................Wppl.authh.spsslsshl...........................hGLhlSlPlhs.t.p.....assFshlhLRlsh.....................sst......phh-lhFhYt-Llssttch.tpstph.....................................................................ssss.sssstpsplp..sshp-Ihphhppsst....shst................................................tsshsuhhpssh..................t..t.tpststptsuLEsPuplRGtt..................................t..psts..phhssshsthss.ssshsstWpt..pslslshhpHhhosp.phhVlsYppShshstptph......sslsp.ht.......................tphshhss.h.............shpsEhthlhphtsthhssltpshppp........th..pltQplshpl...........................psppthpplscph.cuhtslhstlsp.......sSullcAsluphstpstt......hhs......................shhLa-htssshGcslc.hspsslshththphh......................ssstthhpphhsGcshta.....lClha.spsLpshlVLPGGFulpuphsh	...................................M-sHlhs-hth........sspsthhlHl.llsppsLtttthsh..............................................ht.hhhps.sphpssstp.s..............................Wpps.Fsthh..s.tltphL..s..........t.h.........p....hGLhhSLslhh...p.....asshsshtLRlsh.........................sst..........phhsl.Fhht-Ll..thch.tcspph...t.t.hth.........ths.t...................................................t.st.ssss.tstlt..p...Elhp..hhppsst............................................................ttshsuhhpsth..................t...tttptsth....hssLEPPuphRhht..................................t.p.ps..chhsts.tt.ts.tst.sp.Wpt..tslplh.hpchtstt.phhVl.YppShhhstchsh......psl.thls........................t.....................shtschthhhphttsshpslhtslppt.........th..pltQhhthpl...........................tpp.hhttlhchh.thhtshhpthst.......poshhpAhhupLstttst.......hs........................shhhh-hhpss.G-sl+.hsps.lshshphpht.....................sststhhhpphhsGc.hta.....lClha.s.pcLpshlVLPGGFuhphpls..................................	0	0	0	0
+2923	PF04544	Herpes_UL20		Herpesvirus egress protein UL20	Kerrison ND	anon	DOMO:DM04384;	Family	UL20 is predicted to be a transmembrane protein with multiple membrane spans.  It is involved in the trans-cellular transport of enveloped virions, and is therefore important for viral egress.  However, UL20 operates in different cellular compartments and different stages of egress in pseudorabies virus and herpes simplex virus.  This is thought to be due to differences in egress pathways between these two viruses [1].	25.00	25.00	43.10	32.70	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.04	0.71	-4.45	16	54	2009-09-11 15:08:44	2003-04-07 12:59:11	7	2	36	0	0	45	0	165.10	32	77.71	CHANGED	GssDahloSuhsph.s.tpPsFo+pVllahhSAllL+PlCCllFhhYYhhossthhhlsuhshTshaYh.pLslp.hhhlYtNl+pDcLPLsssQphlluhlssupslsFhssuhptlFtssplFhhlhssptps.......h................shusshlshhushlYusDulsDuluFhLPRhWsRull+	........GssDhhlSSAhsphss.s.pPsFoppslhahhSsllL+PlCClhhhhYYhhTtphhhhhsshshshsaYh.phhlp.shhlYhNl+pDhLPLusstphhluhhssutslhhhhsAhpthFtsstlFhhlhssptp..h.....h................shussshshhAhhlYusDslsDshsFhLPRhWsRslLp..	0	0	0	0
+2924	PF01646	Herpes_UL24		Herpes virus protein UL24	Bashton M, Bateman A	anon	Pfam-B_946 (release 4.1)	Family	This family consists of various herpes virus proteins; the gene 20 product, U49 protein, UL24 protein and BXRF1. The UL24 gene (product of the 24th ORF) is not essential for virus  replication, mutants with lesions in UL24 show a reduced ability to  replicate in tissue culture and have reduced thymidine kinase activity as the UL24 gene overlaps with thymidine kinase [1].	18.90	18.90	22.20	22.20	16.70	16.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.01	0.71	-4.82	16	158	2012-10-11 20:44:43	2003-04-07 12:59:11	11	1	93	0	0	143	0	174.40	32	65.99	CHANGED	LphLPttRt+AGpRsHhRhY+pLhphh...shsplttaLs.........h.tPsspp..sclpLaFEVsLGpRlsDClhllpss.....tphhCallELKTChhss....shposo+psQRtpGLpQLpDoschLpphsP..sGspthplsPlLlFhuQRuL+slhlcp..hsspplpsssstLtshltsht-hssptpl	............................l.ptRhpsGhRsHhchY+tlhp.h...shsthsthLs.............h..h..shhpt.s+hpLhaEVsLGpRhPDClslhp.s...........ps...........ttshChllElKTChhsu......shpsso+ptQhspGh+QL+-ohphlpphsP....sGsp.hhhlsPhLlFhsQ+uL+s.hspp..hhspplpsshsslhshLtphp-hsl.h..h.......	0	0	0	0
+2925	PF02760	HIN		HIN-200/IF120x domain	Bateman A	anon	Bateman A	Family	This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain Pfam:PF02758.	22.70	22.70	22.90	38.00	20.50	22.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.99	0.71	-4.89	10	158	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	24	18	53	201	0	163.60	54	42.91	CHANGED	pccPlpVMVLKATcPFpYEosEpth+pMFHATVATcTpFF+VKVFNhsLKEKFltp+lIsIScYacpsGlLEINEASoVSEAsssQshEVPssII+cApcTPKIspLpcQsSGslVYGlFhlpKKpVppKshhYEIpDcTGsM-VVGsGchaNIsCEcGDKLRLFCF+L+	..ppsPhpVMVLpATcPFpYEs.Eptp+pMFHATVATcopFF+VKVFNhsLK-KFhsK+IIsISsYhppsGhLElpc.sSoVS-ssssQphEVPpslIcpAspTPKIspLppQ.spGohV.GlFhlpKKsV.p.p..c.sshYEIpD..sTG.pM-VVspGc.hpsIpCEEGDKL+LhCFcL.....	0	5	5	10
+2926	PF03369	Herpes_UL3		Herpesvirus UL3 protein	Mifsud W	anon	Pfam-B_2492 (release 6.6)	Family	\N	25.00	25.00	64.70	64.60	17.40	16.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.20	15	263	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	36	0	0	58	0	62.50	88	73.24	CHANGED	VsFDTLFMVSSIDELGRRQLTDTIRKDLRhSLAKFoIACTKTSSFSus.sspp+tRtt...sp+sspSNKSLQMFlLC+RAHAt+VR-QLpuVIpuRKPRKYYTRSoDG+o+PsVPVFVaEFsAs-PVhLHRDNVlts	.................................................................................................RKPRKYYTRSSDGRLCPAVPVFVHEFVSSEPMRLHRDNVMLA.	0	0	0	0
+2927	PF02718	Herpes_UL31		Herpesvirus UL31-like protein	Mian N, Bateman A	anon	Pfam-B_1786 (release 5.5)	Family	This is a family of Herpesvirus proteins including UL31 (Swiss:P10215), UL53 (Swiss:P16794), and the  product of ORF 69 in some strains (e.g. Swiss:O36420). The proteins in this family have no known function.	25.00	25.00	56.40	56.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.67	0.70	-5.70	30	120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	80	0	0	108	0	262.80	32	85.44	CHANGED	pup............stss+psppppthh........hshctaFshluppP-hElchLRpMssPIssocslsLPasLsp.hsscsCLsLSshGap.shGusCssCpssupsphsp.................-hsulhLAFlpQlsslhpa+sFahSlls..................tu.chl+pslsQPpLFasYalL+ssshcshslha......tsssshltMYllF.pspslHlspchlcpLhsss.ssYplssDlhpssalLsl....phcp.s...........ssslsssslhcKls-LshssElttEap+hhshhsch	......................................ttstttsts........ths.ptp..p.ttht............+.ph+thashhtppPs.Elphl+.hphPIstppslsLPFshpp.psscsCLsLSshG.p.s.tusCssCtsssp.t.st.................p.sshhLAFlpQhsslhcaRsFhhSlht......................sp-lLctshsQPpLFahYalL+sustc.s.lha.......ssputhhMallF.pspslHl.pchIcphLsAs.ssYclshclhpspaVLsVppp.t.ps.o.............ssplsssslhpKls-lshss-lh.cap+hhshhp-...............	0	0	0	0
+2928	PF03581	Herpes_UL33		Herpesvirus UL33-like protein	Bateman A	anon	Pfam-B_1115 (release 7.0)	Family	This is a family of Herpesvirus proteins including UL33 Swiss:P10217 ,UL51 Swiss:P16792. The proteins in this  family are involved in packaging viral DNA.	25.00	25.00	45.60	45.30	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.48	0.72	-4.08	29	92	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	74	0	0	76	0	77.30	38	58.70	CHANGED	tlhFEsll.Pp-h-llhPTsDA+LNaLsasp+Luuhlpatpst....................tssCsHuplLppKp-thssllsKhLDlcpILcs	...lhFEshl.Pc.h-llhPohDA+LNalshsp+LAuhlcaspst....................sssCsH.uplLppKpchhsullsKhlDlctILc.....	0	0	0	0
+2930	PF03586	Herpes_UL36		Herpesvirus UL36 tegument protein	Bateman A	anon	Pfam-B_3425 (release 7.0)	Family	The UL36 open reading frame (ORF) encodes the largest herpes simplex virus type 1 (HSV-1) protein, a 270-kDa polypeptide designated VP1/2, which is also a component of the virion tegument. A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells [1]. This family only covers a small central part of this large protein.	20.50	20.50	20.60	21.10	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.59	0.70	-5.29	11	176	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	33	0	1	127	0	213.20	54	10.60	CHANGED	tpc-tWtuslcAsLccsEs+ucFDAsElsRLc-hAsstGYcst...ch+ppAEpslsApApsspsAl-uVhuFNPYuspNpt......pshhPPlusL+sloWhDuFssAAPhYspLF.Glss-sLhpLh+IutulLctA.sAssGp..lDYapsVspluuDLttlPpLsKYVDFYp+GascF.shhu+LsphRu-shpAsGshshElutAhEplstlR.sPpsA++sL-tGVplhlPStsslhshsstLcc.DhspFcsTAYtEhh	..............................h...ptWhtsl.AsL.thEstthFsusELsRLRDhAAsuGaDh+...slhspAcQVVAAsts..TusoALDTVF+aNPYTPENss........lsPPLAhL+ulTWhDsFulsAPsaTsMF.GVslEGLhhLhRIpuslLhoA-solsGh..ssYhthlhchutsLhtlPtLttaVsFa.puatpa.t..stlpth+tchh.h.sth.h-hthA.Ephth.+.s.tsAt.hlctG..l..su..hlhth.t.hpp.c.p.h.tTAYtc...............	0	1	1	1
+2931	PF03277	Herpes_UL4		Herpesvirus UL4 family	Mifsud W	anon	Pfam-B_4461 (release 6.5)	Family	\N	25.00	25.00	50.20	50.10	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.06	0.71	-5.06	15	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	35	0	0	68	0	184.80	44	88.16	CHANGED	sThIAYoLpsl+sssshslPchEQllCuh-uGoRulsVGscsRCDpLPsGsllIQHsPlGTLlsVDsts-FCSYthhh....ttppstshpshssshhVhPFsoWsssupspplpSsouGlLTl.hhsssolaITlTlYGps...st.sssh.h.spssspssssshst..ts...............................................tDlLspsl+Euclps	..pThIAYSLpps+uShs.sLPDstQVVpsFEhGTRuIhV+GcpRpD+LPpGsVVIQHTPlGhLlllDCpsEFCuYtFhs....pcpppph.puh-uphaAhPFsSWVuSuRscssRSsouGlLTV.lWsscoIYIThTIYGssspt.sssssps.stssss.spsssss..sup.....h.hQss.........................................tDLLsElLREhpLps.............................	0	0	0	0
+2932	PF05072	Herpes_UL43		Herpesvirus UL43 protein	Moxon SJ	anon	Pfam-B_5928 (release 7.7)	Family	UL43 genes are expressed with true-late (gamma2) kinetics and have been identified as a virion tegument component [1].	24.90	24.90	38.40	34.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.16	0.70	-5.71	9	65	2009-09-11 05:23:58	2003-04-07 12:59:11	8	2	29	0	0	61	0	353.40	33	91.23	CHANGED	GsstssptChtChhssspulhthuhpsulhsuulhll.hhppshAhsshhhssIsshhlsh.hRhshphh-hlshlG+shQhlsshsuulsWslu........stsh.ts.phslssuhhshslhus.lt.apaVshAsusshpa+suhLshssGsllGloshhhslps.shhuhshslls...hssspD....sussLpsTCaY+hsRttslps.scLG+....uhhssss-ssttcEcs.sutsshcsphsh...lhlshVhhlssPhlhslp+hh..ttusphpsstsshhsshsGalluhulp.Lslh.s.pcsLhpsllhhashhtshulsLsshGh.hGsslhLAuusuhuhhsslslRppspshp.....+LAAuplsKslhsslh.....sshhlC	........................Gpsssspsp..lsCshshspuhhtlhlpuAslshshsll.h.ptshA.ssssshhslushhLuh.hRss.shscshsplhthlphhuuhsAhlhWslu.............hshs.ts.phulssuhhshlVhAs.lashahl....ussshFhsshhhlsuGhhlGsSAthh.ls.s.uuhuluhulls...hssspD....As.shccsChhhtsctss.h+sspD.tR....u..ssss..s..ss.........sp+ppsssusplh.sthst...lhlslVshlussslhshsthh..upusshsshshhstshluGHlssuhsp.Ls.shs.shcLocsllhlHsslplhslsLshts.tl.ulhhhLuuAshluLspslslR+Rh+ttc.....+LAAo.hsRuLahslY.....luhhlC.............	0	0	0	0
+2933	PF03387	Herpes_UL46		Herpesvirus UL46 protein	Mifsud W	anon	Pfam-B_2545 (release 6.6)	Family	\N	25.00	25.00	101.70	101.50	15.50	15.20	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.31	0.70	-6.27	11	70	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	33	0	0	71	0	437.90	44	65.51	CHANGED	suhpshS.pslhpcRhctGCL.........LPsPpslhsuAVtALc-ts-slhPssLhuspRpssLhsh+sNpVPESlIlsshusDsps-Yh+pYsushppsLscttLotsslhRslhspYW+YLp..tooGs-lsssstsssss....p.osllLhhsshs.K.Lu+pPFKpcsssusYtsshstL+-AhctlQ+YMYYMRPsDPhssSsDTslRLpElLAYssThYpWhlWhhDslDupVlRpht.h.phstGP.RsshsP-slFtRHLcsGPulsoGo.ussh.............hLssssuslLusLl+luslWppspW+usspG.sssAIVAAVELlollHHHhQYLlNhshsGYssWlcGGlpssaLpuALRuQpRFp+hhG.............pLhPTMospSWushEpuspsWFchAlA+Sllsa...GsPTtaYpslLpsl.........ssP.psphsspsss............stssts.hpstputPPsssu	..................s....t.s.tGlsERRlhsGCL.........LPTPpslLuAAVuAL+p+oD-hpPuhLpss-RustLuuppH.NsVPESLIVcslAuDs+hEYlR+YuuAAppsLu-scLouutlpRulLspYWKYLp..ssSGl-VP-cssscscs......SltlLLpPTlusKhLuRsPFKstussApYsAslAsLRDAl+tlQpYMaFMRPsDPopPSsDTulRLpELLAYVusLY+WA.Whl.TsDt+VC++Ls.ssR+hhsh.tuspuPs-hFuRHL-pGPosooGS..hpsh.............sLpAulucVLupLpRLusLWpsuchpuGTaG.sscslVusVEllSlVHHHsQYIINhTLsGYssWussuLsNpYLRAAlcuQcRFs+hsu.............sLFPTMousSWAcMEhSl+uWFstALAtsLLpp....GsPoh..HYcslLchl........uSp.sphptussPss....................................st.............................................	0	0	0	0
+2934	PF03362	Herpes_UL47		Herpesvirus UL47 protein	Mifsud W	anon	Pfam-B_2182 (release 6.6)	Family	\N	25.00	25.00	163.40	101.80	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.28	0.70	-6.16	13	117	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	34	0	0	101	0	414.00	36	60.55	CHANGED	cshcEcphhctpss.hs...hstW.u..sssastGsMYsusPs..csthsa+RshpQutALhh+lstsuLpsulssp.thostcAlhFLlDAslRlAtNsahsupp..................hhtthphhoslp.lPtusus.lLpssshpsP..............tpGPpAAlhRuuhGuLsYWPELRssLsc.schhlRYAtsth.hAEsaLLARhp.utpsuhsspEhc....hLushlTLhsllActslpaLhsusuthLp.scssctshptsptststptlPlsS.tLhsAEstsLushsusph.htssuLutshssuYhAlR....oAhTsLhh-au.t.....sptptcsscthssAhLussllLQRLLGHhNhlLspLstAAhhGGpsl.sVhptThtcYphLhpsssPLYp.sols-Fhc-R--AMcpLcLcs......ssu.sPhsuhchl....lp.tht.ssL-slh....shs.ssshshLGshVsls-hltca+chlhuc	........h.h..Ep.hh......ht....stW.s..t...s.GtMahtt.s..s.hsh.hpsltQupAlhaphhhsshhsthspp..ho.spuhuFLhD.AslRluhNshhhupp.................pshthhp.hhh.stLtslsttuss.lLpssthshP..............ppGPpsAlhRu.hGuLhYWPtlRhhlscssp.hsRYAstth.lA-hhLhuRhp.shpsphsspEtt....hLuphhslhsshutthlpWlphssuhhLt.sh.s+sAahsVstp..ahhlPlsSshLssAEstlLGclsssss.hts.ALssshhsuY.AlR....TAhoshhlcaA.......cstcpspschhspAhLussLlLQRlLGHANhlLshLstAAhhGGhsh..hlhpso.ctYspLhhAssPLYsppThscFW+DhcsAhcplslcP......sos.sP+sshRhl....Ic.shhh.sL-sh.....Pt..........Pp.Vcls-.h.paRp.lhG........................	0	0	0	0
+2935	PF04823	Herpes_UL49_2	Herpes_UL49; 	Herpesvirus UL49 tegument protein	Mifsud W	anon	Pfam-B_3850 (release 7.6)	Family	\N	25.00	25.00	27.60	112.50	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.11	0.72	-4.02	13	97	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	34	0	0	91	0	96.10	58	33.54	CHANGED	sRAsPGsp...slstuK.luFSssPsosousWpusThuaN++lFCtAVutVAttHAptAAtuLWDhssPRoNE-L-chLptAsI+ITVsEGhsLlptAN	..........s.........tuhu++LpFSTAPsoPoAPWsspssuFNKRVFCAAVGRlAAhHARhAAlpLWDMspP+TDEDLs-LLshssIRlTVCEGpNLLQcAN..	0	0	0	0
+2936	PF04540	Herpes_UL51		Herpesvirus UL51 protein	Kerrison ND	anon	DOMO:DM04380;	Family	UL51 protein is a virion protein. In pseudorabies virus, UL51 (Swiss:Q85227) was identified as a component of the capsid [1]. In herpes simplex virus type 1 there is evidence for post-translational modification of UL51 [2].	25.00	25.00	33.60	33.50	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.66	16	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	33	0	0	50	0	160.80	50	66.65	CHANGED	lCGhtstscc..pYE.lpsss..sss.s.hRLpEAlssVNsLLPAPlTlEDsltSADssRRLV+ApuLARTYpAC.......RNLECLu+HpsutsssuL-AVVpsHhtsspRlADTChAuLhphYhSVGAs-tsTDshV-QAIRhsAEo-lVMuDVAllE+ALGlsupssssu	.........lCGhttpspc...pYE.lpsus..ssstu.hRLpEALssVNuLLPAPlTLEDsltSADsTRRLV+ApuLARTYpAC.......+NLECLuRHpsut-sPsLDAVVtsHtpss+RLADTChAulhphYhSVGAsDtoTDshV-QAIRhsAEo-VVMsDVAllERALGLsst.t...sh...	0	0	0	0
+2937	PF04537	Herpes_UL55		Herpesvirus UL55 protein	Kerrison ND	anon	DOMO:DM04378;	Family	In infected cells, UL55 is associated with the nuclear matrix, and found adjacent to compartments containing the capsid protein ICP35.  UL55 was not detected in assembled virions. It is thought that UL55 may play a role in virion assembly or maturation [1].	25.00	25.00	26.40	25.40	17.80	17.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.48	0.71	-4.86	7	43	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	31	0	0	35	0	164.90	38	89.39	CHANGED	ttsh.sshp.stlsslhpVlsPLsl-soapSsp.spcpPsssshhlssRoYhlRAsCppssclHAFFhGLupcss.shs..hsslpshsplhNpp.hhpchtshp...phCcuPFStATlhDsl-ss.....shsIpGlsaHCHCcs.FSh-CWtuA.tAh-+lsshs+shpshst	........htss..sshhhphPslopVssPhsLssoWpupp.s.......hcssps.......ssuslssRoYllRAsCsossslHsFFaulhc-tstphs..hs-LcsFscllNp..llpELtsc+.stthCssPFSsuTIhDssssut..........phsIsGlsYHCHC+sPFSh-CWpuAsuAhp+ltSlupuhtusp.t........	0	0	0	0
+2938	PF04534	Herpes_UL56		Herpesvirus UL56 protein	Kerrison ND	anon	DOMO:DM04377;	Family	In herpes simplex virus type 2, UL56 is thought to be a tail-anchored type II membrane protein involved in vesicular trafficking.  The C terminal hydrophobic region is required for association with the cytoplasmic membrane, and the N terminal proline-rich region is important for the translocation of UL56 to the Golgi apparatus and cytoplasmic vesicles [1].	25.00	25.00	32.70	29.00	20.80	19.60	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.34	0.71	-4.60	3	23	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	0	0	22	0	193.30	71	84.13	CHANGED	MASEAAQPDAGLWSAGcAFADPPPPYDSLSGRNEGpFVVIDlDTPTDoPPPYSAGsoLlGPlsPsSSG-GEssERGRSRpAA.RAARRARRRAERRARRRSFGPGGL.luTPLFLPEThluAPPDVsuDLlSGLPTYAEAsS........DHPPTYATVsAA........RoTEQPuGuluPsDQPRoQsSGsWRPPpVNSRELYRAQ..............RAARsu	...............MASEAAQPDAGLWSAGNAFADPPPPYDSLSGRNEGPFVVIDLDTPTDPPPPYSAGPLsSVPIPPTSSGEGEASERGRSRQAAQRAARRARRRAERRAQRRSFGPGGL.LATPLFLPE.TRLVAPPDITRDLLSGLPTYAEAMS........DHPPTYATVVAV........RSTEQPSGALAPDDQRR.T.QNSGAWRPPRVNSRELYRAQ..............RAARGS....	0	0	0	0
+2939	PF01763	Herpes_UL6		Herpesvirus UL6 like	Bashton M, Bateman A	anon	Pfam-B_878 (release 4.2)	Family	This family consists of various proteins from the herpesviridae that are similar to herpes simplex virus type I UL6 virion protein. UL6 is essential for cleavage and packaging of the viral genome [1].	22.00	22.00	22.20	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.70	0.70	-6.33	30	194	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	91	0	1	167	0	449.10	31	82.83	CHANGED	htahEILpGchuYscGQslasulRsssshhRQl.sslh+ssLsussY--ltsDWppHhss.......lspRastppptps.thtcpsFpoWppTL+hoLhchlpshls.hlastssss....Ys+YlDWlsslGlVPll+p.....s.......tt.hhpphppthppstppp.ssp.+lhssllppstphlpplhpslsultIs-asclpIhashpppphhsh..hssc+hcshVlhpPlhts.spllFDSPlQRLatElhpCasLpEHAKlCQLLNTuPlKlLlGp+scs......ssp+ll-+l...-ppspsusAtpcLl+Lllslps.+plusITDsV-saLp-sossllDpsplhssststh..........................spssppul+cpVssslh+sLEs.INp.FcTIcsL+ptNcshhp+lpphEspLp+hppc............spsssss..................sspl.s.sshpulptl...hppslh.sosshs-sphVANSFhSQYlPsac-phccLopLWEpElhRsFKLs+lssNQGpElulsYSssoIolLLuPahaslLcltpls.LlscphshhS.pElssslacpSRLpsYlsDlut+a.....s	..............hhFhclLpGphGYspGQslapslRsspshh+Ql.hslhpthLsusshcclhs-Wppahp........h..+ht.ttt.t..thtpphapsWttoL+pollshltsllt..has.st.s....as+YlDWlsslGlVPlhch..................ht.h...h.h..tt......thssphhtpsh.hlhplspshpustlhsascsplahphpptph.sh..hpspchchhVhh.Plhh.....t.ttllFsoPlt+lh.ElhtpptLpcHt+lCpLlNThPlKslhsp+pp.......thtchlphh...pppsptssAtppll+hllNhps.+phhslpDoVcualp-hsspllD.s...hssp.s............................ts.thppsh+s.hhppl.thLEt.lpp.hppIppL+phNtth.pplpphcttLp+httt............t.t..t........................ph.p.sh.tshphh....t.tl..hsh.hs-sthlsNSF.upalPshtp..ccLopLWEpEhhRsF+ltphhssQGtE.ul.YSs.slthhlhPah..llph.pht..lstt.h.hu.tElhtslacpo+hphYlp.lt.h..................................	0	1	1	1
+2940	PF01677	Herpes_UL7		Herpesvirus UL7 like	Bashton M, Bateman A	anon	Pfam-B_1086 (release 4.1)	Family	This family consists of various functionally undefined proteins from the herpesviridae and UL7 from bovine herpes virus [1,2]. UL7 is not essential for virus replication in cell culture, and is found localised in the cytoplasm of infected cells accumulated around the nucleus but could not be detected in purified virions [1].  Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication.	25.00	25.00	58.00	57.70	18.10	16.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.38	0.70	-5.01	33	122	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	82	0	0	109	0	220.00	27	77.39	CHANGED	hshEV+cs.sshslthsssslsshsV....tttlhh.h.t...sshhshcsYhppphspssFtGFshsslsssEDtVpslslsPhllpcRhsla+PpshhcFpLCsll.hLENh..tssosshhhplhshLchlts+.ss.sphsphLhpusphLlsTlhhhath..tshcsphllsphshh+h..Lhp.tpssshsllpsla....t...hpshpLstsspps........hhhcstsuh..hNthass	......hshEV+ps.sshtsthsusslsshsV....stplhhhhps...sphlsscpYhppshspsuFtGFshsslsssEDtVpslslsPhlLpaRhsla+Pcshh-FpLCsLlhhLENh..tpsosshhhplhsaLphsts+.ss.pphpphLhpusphLlsThhahhth...shcsphllsph.hhch..Lht..tsss.sllpsla....t.s.tsshpLstsstps...............tthhps.suh..hs.hh..s...............	0	0	0	0
+2941	PF03554	Herpes_UL73	gpUL73; 	UL73 viral envelope glycoprotein  	Finn RD	anon	Pfam-B_3001 (release 7.0)	Family	This family groups together the viral proteins BLRF1, U46, 53, and  UL73.  The UL73-like envelope glycoproteins, which associates in a  high molecular mass complex with its counterpart, gM, induce neutralising antibody responses in the host.  These glycoprotein are  highly  polymorphic, particularly in the N-terminal region [1].	19.60	19.60	20.20	20.00	17.90	19.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.95	0.72	-4.16	16	253	2012-10-01 21:33:21	2003-04-07 12:59:11	8	2	54	0	0	165	2	89.80	51	77.14	CHANGED	hhshsstshsstssspspssssssspspssFYshsCsADTYt.oLsSFSSIWsllNslllhsAsslaLpYhCFp+Flsshs+	...........................................hso.hooT.STTSTKsoSTTHDPN.VM+tH.spsDFYcAHCTSHMYELSLSSFAAWWTMLNALILMGAFCIhLRahCFpsFsspTh.......	0	0	0	0
+2942	PF01802	Herpes_V23		Herpesvirus VP23 like capsid protein	Bashton M, Bateman A	anon	Pfam-B_1435 (release 4.2)	Family	This family consist of various capsid proteins from members  of the herpesviridae. The capsid protein VP23 in herpes simplex virus forms a triplex together with VP19C these fit between and link together adjacent capsomers as formed by VP5 and VP26 [1]. VP3 along with the scaffolding proteins helps to form normal capsids by defining the curvature of the shell and size of the particle [1].	25.00	25.00	26.60	26.60	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.63	0.70	-5.38	32	501	2009-09-11 06:10:29	2003-04-07 12:59:11	12	1	91	0	0	208	0	163.90	62	98.31	CHANGED	tplhlslss+Loss-lupLQcphGpllslssh++hhslpsluLpshh.tssssDalplhshh+cphhAllpcVpsspllhshlshG....psht.l+NT.uP.FphssGDtlsllPPlFst.pssl.pLpSssh-LlFPhsVPpsLApEllt+llshslhuhststp..tsshsch...hpslpYpG+pasLs.shpptss.s.ssl+sLslshshhss.ustllhsllss.Lshpspc.hlsthhplhsspp.................hphhc.sshsh.pDhsR...............lsuahohhppLuslhshpshhpVssas.ssspssss......h	........................................................................................s.....sht.lpNs.uP.hphppss.lsllPPhFt....t........sp.......h.hL-SNGFDLVFPMVVPQQLGHAILQQLLVYHIYSKISAGAPsDVNMAELDLYTTNVSFMGRpapls...........................................................................................................................................................	0	0	0	0
+2943	PF03327	Herpes_VP19C		Herpesvirus capsid shell protein VP19C	Mifsud W	anon	Pfam-B_3451 (release 6.5)	Family	\N	25.00	25.00	30.10	53.50	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.55	0.70	-5.52	31	121	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	83	0	0	106	0	283.70	27	73.81	CHANGED	shsp..shhschhhttttlsptp.shus.hh.hhpsss...suhcslllSlshlshs....h.st..ssusul+shltshYssp...upLtphssslpthlpsp.a.HchlpslGsllpslspshlsplTsVh+Gsshstpsspht.....slh.......lPs-hFlDlDt.h.....................ttspsuhphlYlshlYspph.pcttspla.hhpSttscpslhshLchhaushRtpph.......................................................slpspsshsphhaGAhs+LGhhssssshp.....psphphpussLPVVplpshhsc.hGsWp.h	..............................tpp.stchh.shtpltptpshus.....tpsss...susRshllSlsFLshs....h.sp..suusAlRstltu.Ysss.htscLschstsLpshlcs+sa.HchlphhGsLlphlopstlsplTsVspGsp.uscsspss....sslh.......lPushalDLDtph.....................thsssustalYLlhs.Y.ppct.scptsplY.lhpSp.hs.psltssLcthFuchRhspshp.....................................................clpu.psstpsssauAhscLGhhsps.sshp....+sphh.tusslPVVhl-shshc.sG.sWpth...........................	0	0	0	0
+2944	PF01521	Fe-S_biosyn	HesB-like;HesB; 	Iron-sulphur cluster biosynthesis	Bashton M, Bateman A, Wood V, Mistry J, Eberhardt R	anon	Pfam-B_518 (release 4.0)	Family	This family is involved in iron-sulphur cluster biosynthesis [3]. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins [1] [2].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.35	0.71	-4.13	98	8207	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	3441	17	2003	4486	4099	102.60	30	78.59	CHANGED	Mplsl..TcsAtpplpphhss.ppt.........lhLshcsGs........th.Cuh.uspaplhhls..cs......ssh-hhlc.ssshslhlcs..hstsaltpshslDas.thtshsLp.ssss.hlssssslsc	........................................lpl..T-.uA.sp..+lppllsp.psps...........................tlR.lhVpsuG............Cu..GhsYshshs.c...cs...................................spsD.h..s....h.......E.....p.....p..........G......l...p...l......h..lDt..hSh.aL...s........G..s.p.lDa.s.c.s.h.h.sp.t.Fp......hpN.P.Nu.p.s..p.CGCG........................................	0	581	1176	1615
+2945	PF02444	HEV_ORF1	HEV_ORF2; 	Hepatitis E virus ORF-2 (Putative capsid protein)	Mian N, Bateman A	anon	Pfam-B_1896 (release 5.4)	Family	The Hepatitis E virus (HEV) genome is a single-stranded, positive-sense RNA molecule of approximately 7.5 kb [2]. Three open reading frames (ORF) were identified within the HEV genome: ORF1 encodes non-structural proteins, ORF2 encodes the putative structural protein(s) [1], and ORF3 encodes a protein of unknown function. ORF2 contains a consensus signal peptide sequence at its amino terminus and a capsid-like region with a high content of basic amino acids similar to that seen with other virus capsid proteins [1].	19.70	19.70	21.60	21.60	18.30	18.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.68	0.71	-3.88	3	266	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	12	0	0	229	0	81.00	74	96.04	CHANGED	MGS.PCALGLFCCCSSCFCLCCPRHRPVSRLAAVVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLAFANpPuHLAPLGVTRPSAPPLPPVVDLPQLGLRR	.Mt..PCALGLFChCSSCFCLCCPRHRPsSRLAsssGGAAAVPAVVSGVTGLILSPS.SPIFIQPTPS..h...pPGLELALsspPs..AP.G.................................	3	0	0	0
+2946	PF02455	Hex_IIIa		Hexon-associated protein (IIIa)	Mian N, Bateman A	anon	Pfam-B_2076 (release 5.4)	Family	The major capsid protein of the adenovirus strain is also known  as a hexon. This is a family of hexon-associated proteins (protein IIIa).	25.00	25.00	47.90	47.90	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.58	0.70	-5.81	13	134	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	100	1	0	130	0	481.10	62	87.16	CHANGED	KVLsIVNuLl-spAIRsDEuGtlYsALLpRVu+YNSsNVQoNLD+LlsDV+pulupp...RhhcsssLGShsALNuFLuoLPusVpRGQENYsuFluALRLhVsEsPp.oEVYpSGPsaalQsuRpG.lpTVNLopAFcNLpsLWGVpssstc.psslSSLLTPNTRLLLLLlAPFT-usolS+DSYLGaLlTLYREslusu.clDEcThpEIspVuRALGs-.DsusLpuTLNFLLTNRpp+l.PssaoLosEEEpILRaVQpuluLhlhp-sts.sosALDpsutsh-PSFYuuNRsFINRLhDYhcRAAAhsPsYFpphlhNP+WlPPsGFaTGsa-hP-...-u..FhWDcscs................phhcccss-cpscstss....sssssutPuS.hsphs........................................uphspshhsGss-.....lhtPtps+N............h.Nssl-pLlDthuR....W+Thtp-.t...............++.+.tt......sc-ssucpsshhchtGsG...........tNPFAHL+P..+u...pha	....KVLAIVNALsENKAIRPDEAGLVYNALLERVuRYNSoNVQoNLDRLVTDVREAVAQRE..RF.+sssLGSLVALNAFLuTQPANVPRGQ-DYTNFlSALRLMVoEVPQ.SEVYQSGPDYFFQTSRQG.LQTVNLoQAFKNLpGLWGVpAPlGD.RuTVSSLLTPNSRLLLLLlAPFTDSGSlsRsSYLGaLLTLYREAIGQA.pVDEQTaQEITsVSRALGQp.DTsSLcATLNFLLTNRpQKI.PsQYuLoAEEERILRYVQQSVuLaLMpEGAT.PouALDMTARNMEPShYAuN.RPFIN+LMDYLHRAAAhNs-YFTNAILNPHWLPPPGFYTGEaDhP-s.NDG....FLWDDlDs................thh.ptph..tcc..tsts......sstts..stsus....hPSLst.hs.stSst......................................................GRloRPRL.GEpEYL..NDsLLpP.RtKN............hsNNGIESLVDKhsR....WKTYAQ-pR-..ts.............t.pp++pppth........---DSADDSSVLDLGGoG...................sNPFAH.LpP+h.h...h...........................................................................................................	0	0	0	0
+2947	PF00349	Hexokinase_1	hexokinase; 	Hexokinase	Sonnhammer ELL, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF03727.  Some members of the family have two copies of each of these domains.	20.20	20.20	20.50	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.36	0.71	-4.99	14	1806	2012-10-02 23:34:14	2003-04-07 12:59:11	16	20	455	60	944	1749	11	195.20	35	42.73	CHANGED	pshhcplcchhptFplosEpLpclsc+FhpEhcKGLs..+csss........l.MlPsaVtshPsGsEpGDFLALDLGGT..NhRVlhVclsGsp..ph-hppppYplP.......cclhpupu...cpLFDaIA-ClpcFh-cht........pspsLPLGFTFSaPspQsulspuhLlpWTKGFch.....sssEG+DVVsLLpcAIp+Rshs.lcVVAllNDTVGThhussYs-	...........................................................t......lpph.t.h..p..ls..pp..p....Lhplhpphhp.-h...ppGLp......pcs....ps..................................lpM.lPoa...Vp...s...h...Ps..........G....s..........E.p.......G..p.a.LA.LDLG..GT..NFRVhhVpl..pspp..................sh.c.h.p...p......p......h...a.s...lP..........................................pcl.h.p.Gsu.................ppL..F.-aIApslsc..Flcp.p.t.h.............................p.....t..p...pls..L.GFTFSFPspQss....l..s.p..Gh.Ll.pWTKGFph.....................s.s.s.....G..c..D..V.Vt...h..L...p......c..A.....l......c+......+......s....................................................l.......cl.s.A.l.lNDTVGTh.hussYp..................................................................	1	201	397	678
+2948	PF03727	Hexokinase_2	hexokinase2; 	Hexokinase	Sonnhammer ELL, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF00349. Some members of the family have two copies of each of these domains.	21.30	21.30	21.40	21.40	19.60	21.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.45	0.70	-5.17	15	1869	2012-10-02 23:34:14	2003-04-07 12:59:11	11	20	457	61	998	1816	6	217.50	34	49.64	CHANGED	psclGlIlGTGoNuCYhEchppIptlcG.........spupMsINsEWGuF.DstpLs.sRTcaDlslDcp.SsNPGpQtFEKMISGhYLGEllRhlLlcLscpGlLFc.....Gptss+Lpsshhh-TphlScIEsD.pcsLccscslLpp.LGlpsTss-phll++lCclVupRAApLsusGlAAllp+....RGhcthpsslGsDGSVYcpaPpFpcth..tpsl+-Lhsc.....s-..lshl.uEDGSGtGAAlluAVAt+	........................................................stlG...lIl.........G..T.GoN.As.Y.hE.ch..p..s..l..t..h.hps............................sps..p..M.slN.hEW...GuF....Ds...t......h..t......tTcaDpt.....lDp............t.....S.................h....N........P..........G................p....Q..............h...a...........EKMlS..GhYLGEl.lRh.l.Llc.h.h..p..........p....s...h...l..Ft.......................s.p...h...s.......p.....p...L....t.p........h.h.....hp..............Tph............l.S.t.....l.....c.........p.....D.........................p...................s............l...p....p........s.p.p.lL.......p.......p.............l...........s.......l......p......s........o...t........p.......-.......t.h...hl.pplsphlupRuA.p.Lsus.............ul................u.ul...................l...........p.......+.....................................................................p............t........................t.....................................p..........ss..lusDGola....ch...a....PpFpphh..pp..s..l.p...p...l...hs................pp.......lph..h.u..cDGS..GhGAAl.lsA.hs.........................................................................	1	215	418	718
+2949	PF03559	Hexose_dehydrat		NDP-hexose 2,3-dehydratase	Bateman A	anon	Pfam-B_1070 (release 7.0)	Family	This family includes a range of proteins from antibiotic production pathways. The family includes gra-ORF27 Swiss:Q9ZA32 product that probably functions at an early step, most likely as a dTDP-4-keto-6- deoxyglucose-2,3-dehydratase [1]. Its homologues include dnmT from the daunorubicin biosynthetic gene cluster in S. peucetius [2], a similar gene from the daunomycin biosynthetic cluster in Streptomyces sp. strain C5 Swiss:Q53880 [3] , eryBVI from the erythromycin cluster in S. erythraea and snoH from the nogalamycin cluster in S. nogalater. The proteins in this family are composed of two copies of a 200 amino acid long unit that may be a structural domain.	25.00	25.00	49.50	35.60	20.40	15.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.01	0.71	-5.30	79	286	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	121	0	55	284	181	203.50	38	87.16	CHANGED	psss-lhuWlspp+s.ppchpscRlPLscl..su...Wphssss..lsHcoGRFFsV.GlpVps.....ss.pcV..ssWsQPllp.sph..GllulLs+chcGVLHhLhQA+hEPGshsslpLuPTVQsT.uNYsplppusps.aL-hhhsss...s...RVhhDslQSEcGuhFh+tcNR.hlVEs..s--.........lshsss..FpWlTluQlppLL.ppsphVNhpuRTlLuCL	................sclhuWlspp+s.tpphpsc+lPLscl.....suWphssss..lsHcsGRFFsVhGlpVps..........ss.ptV......spWsQPlIptsph..GllulLs+chsGVlHhLhQA+hEPGsh.s.s.lpLuPTVQsT.uNYsphttu.....tps..aL-hhhss....s...t..s..............cVhhDslpSEcGupFh+pcNRphlVEs...s--.......................ls...s..ssFpWlTluQlppLl.p.psshVNh-uRolLuCL........	0	14	41	49
+2950	PF04209	HgmA		homogentisate 1,2-dioxygenase	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Homogentisate dioxygenase cleaves the aromatic ring during the  metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria.  The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangement comprised of a dimer of trimers. The active site iron ion is  coordinated near the interface between the trimers [1].	19.30	19.30	19.30	19.30	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.53	0.70	-6.08	14	1185	2012-10-10 13:59:34	2003-04-07 12:59:11	8	6	998	2	527	1251	479	378.40	34	93.62	CHANGED	pYhoGFGNcapo..EulsGuLP.GpNSPQpssaGLYAEQLSG.oAFTuPRppNpRoWLYRIpPSssHtshh.hc....tphhsssast.ts..sPNpLRWpPh.lP...ppssDFV-GLholsGuGcs..hsppGhAlHhYtsNpSMtscsFa.NADG-hLIVPQpGtLplpTEhGclpVpPuEIsVIPRGh+FpVplh.ts..sRGYlsEsaGspapLP.....DLGPIGANGLANPRDFpsPV......AtaEDpcs....hpllsKapGpLassc.sHSPhDVVAWHGNYsPY...KYDLppFsslsoVuFDHsDPSIFTVLTuPSspsGsAssDFVI..FPPRWhVAE.cTFRPP..aYHRN.....sMSE.........FMG..LIpGtY-AKptG.FhPGGuSLHshMosHGPDhpsFEtAopA...-L+Pp+..ls-.ohAFMFEophshtlocaA.hctpplppsYhpC.WpsLcpcF	..............................................................................................................t...................................P.p.s..h.s.LYtEphsG.osFh.ss.......pohhY+.h.h.s...ss.p....h..........................t....h.......t......s...h....t...t...........tph..R.h...s.h.hs..........t....hsalpGhhs.hsususs.....htpp.shtltlat..ss.p.uM..............s..c.h.Fh..NA.D.GD.Ll.hsppGp..hcl.....tTEh.....G.p..............lp....lpss-hslIP.R.Gh..pa+.............l....ph......s.s...................sRsa.lh.Esh.s....u....thpLP......-h..G.l.G.s..pu...l...h...ssRDhpsP.s...............A.t.a...p....-..c.cs.............saplhsK..hp......G........p.......l.......a..p..s.....p..h..sa..sPh.DVVuW.HGshsPa....................+aslccFpslsohta.H.sPSlasVh............p.s....Ghs.lssFV.....PR.h.s.u-..ps..h+..sP..aaHpN.....lh.S.E...hhG...h.l.pG.sa-.A.p.......t.....p....G...FhPGGhS.LHssh.sHG.P..cstsa..-.t..A.p.u.......p.l..t.....pc....hs-...h...AhMh-Tp.............hslpho.chA.h...p...s.....t....hpt..pYh.t.s.Wt...........................................................................	0	150	295	428
+2951	PF01085	HH_signal		Hedgehog amino-terminal signalling domain	Finn RD, Bateman A	anon	Pfam-B_1424 (release 3.0)	Domain	For the carboxyl Hint module, see Pfam:PF01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.	20.00	20.00	20.70	20.20	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.16	0.71	-4.68	4	383	2012-10-02 01:02:30	2003-04-07 12:59:11	13	11	169	34	136	371	1	126.60	72	36.71	CHANGED	CGPGR..shGRRR.sRKLsPLsYKQhhPNVuEpThGASGhhEG+IpRsSERF+-LsPNYNsDIIFKDEEpTGADRhMTpRCKDKLNuLAISVMN.WPGV+LRVTEGWDEDGaHucESLHYEGRAVDITTSDRDRsKYGMLARLAVEAGFDWVYYESKuHIHCS	..................................................................p.hsh..hKQh.PslsEpshGASG..EG+lsRsst+F+.-.L.ss.NY.NsDIlFKDEEso.GADR.lM.TpRCK-+LNsLAISVMNpW..P....G..VKLRVTEGWD..E......D.G.H..............H...uc-SLHYEGRAVD...IT.T....SDR....DRs...KY...GhLARLAV.EAGFDWVYYES+.sHlHCS...............................	0	33	44	85
+2952	PF00730	HhH-GPD	Endonuclease_3; 	HhH-GPD superfamily base excision DNA repair protein	Bateman A	anon	Pfam-B_854 (release 2.1)	Domain	This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [2]. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases such as Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7 also contains a related domain [1] that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null --hand HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.54	0.72	-3.76	72	13897	2012-10-03 02:11:09	2003-04-07 12:59:11	20	76	4824	121	3791	10642	6191	138.90	24	47.70	CHANGED	lssllspQssspsspphhtclhpth...............h.sscsltphs..pclpplh.................hGhhppKAchlpphuchlhcphtuphspshpphtt............................l.GlGthoushhhhhuhsh.p..hhs..lDstlpRhhpRlhhhpt....s.cphppph.chht.	..............................................................................luhllspQsss.tsl...t.thh.tchhpth..........................................................................PT...sps..l.u.s.....s....s....-clh.p.h.hps...................lG.h.a.s+A..+....s.lp..psuphlhcpasuphPpshppltt......................................................................................................................................................................................................................................hsGlGhtoussshhhuhuh.....hhs..VDspl.t.R.l.h.s.Rhh..hh.pt............s.tp..hcpth.t..........................................................................................................................................	0	1240	2398	3196
+2953	PF03753	HHV6-IE		Human herpesvirus 6 immediate early protein 	Finn RD	anon	Pfam-B_1006 (release 7.0)	Family	The proteins in this family are poorly characterised, but an investigation [1]has indicated that the immediate early protein is required the down-regulation of MHC class I expression in dendritic cells. Human herpesvirus 6 immediate early protein is also referred to as U90.	25.00	25.00	27.00	26.80	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	993	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.99	0.70	-13.75	0.70	-7.07	3	44	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	6	0	0	41	0	565.20	63	91.78	CHANGED	YSoNVEEGASs-FKhllAQSlGNCIQSIGASVKAAMKQEQSDMEDsLINsAGLLTpcRSMLpcLuLEQLSQLININLLSSASSpFVSsYuKMLSGKpLDFFNWCEPRFIVFACDKFDGLVKKVASESR-LLhDLRANMNN-FIKAlKcIFSKAsVsLDspKLNpsATMLLMMAHNKEMSNP-ISNc-FCcKlNpLKQ-LLEuKNEIIEsNuKNMQhhQ-FAIKQMNQIFMDsCDKTFLKIHlNCKNLIoAAKNLGsAVLQSIVICSNEFSWQ+LKspR+pFKITMMsMITcACEpIEolYDDTGLIKPLsSlsIMEGYIshNKNRpSSICDuNlDPSDShlLELtDFDDHGKYSEESS...IESIHEDDDN.............................lsh.ph.-.ppspsssh.sPphsscp.phphhppIcppsluKMYPsTPSPDVPGKSKEs.......cTFlEsSRQoGcEQTSPNCVCT.......ASVTDLGGPDNlKSITGLpSu.......KchLlK+LLDTQsDSVVs.........pTsStpp-hhshS..phppscEhhQ-KsS..............psKpT-s.sG.........................TFoposp.spS.uuI..phs..sK.sp-hEth.pLhshsDGopDNPLISEMLoFGYETDHSAPYESESDNNDEIDYIAssDSusRTNNIHMNNTNENTPFSKSlpSP..PEVTPSKcsaKs-KhsslSpppKsKKRTA......................................KRKsVuhKosKSKKIKoDpLPcsTNVIVIS......SESEDEEDGsNIIcKShLcKsIKSEscSESSS.............ESDDCTSEDNpLHLSDYD............KVINNG.cCpSKGFPSPVFTIPIRSMpG.THGIRsKFVPKKNWLWFMRKTHKVDNCPIHSScKsNsK-DSDsTEAsHCFhNHFVPIKTDDEEY-KENVSYIYsKIQ-SKIDlEsITPTK+LIT-MlMDNFMDLTDIIKpGIsKHCQDLssKYsVlT.TsCEKsLNVsNSQslsTstTQlFDPsVTGNNSsILNIINDTTsQNDENRCTEGTSNsNEKCTs+SDCNSDpTEVFKLDGYPSDYDPFlENAQIY	......SsNVEEGupt-hKsLsAQSsGsCIQSIGA...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2954	PF03486	HI0933_like		HI0933-like protein	Griffiths-Jones SR	anon	PRODOM	Family	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.17	0.70	-6.00	49	4052	2012-10-10 17:06:42	2003-04-07 12:59:11	9	30	3055	3	923	14035	5432	360.40	33	90.89	CHANGED	hDVllIGuGsAGlMuAhsA..uptGpcVhLl-+spphG+KlhlSGGGRCNlTN..phs.spalsp...Ns+FlpSA.lupFsspDhIshhpphGlth+pccpG+lFsss..pApsllchLlpchcc.tGVpl+hpspVpsl........ttssss.atlps......ssp.plpssslllAoGGhShPphGSoGhGYplAcphGhslhshpsuLVPhshp.tshh.hppLuGlulcslhh.h.............spsthsaptshLFTHhGlSGPAlLplSuah........psstplplDLlPshs..tltphLppp+ttpspptlpss..LsphLPc+lhthlhct..h.t.st..htploppplpplsptl+saslplsGopuhcpA.VTtGGVshcElss+TMpu+tlPGLaFsGEVLDlsGasGGYNhQhAauoGasAGps	........................................................................h.clllIGuGsAGh.hsAhtA..................up..t......G...t..p..V..lll.-..+.....s..........p...c........h........G..............+......K.........l....h........h.......o......G.....G...........G.......R......C.........N........h.......T...N..................t..........h........s.......................s.........p.........h.......l..s......p......................................N.....s.....+......F.....h............h.....S........s........h.....s............p.........a.............s....s...........D............h........l.........s..h.....h...p.p.....h.....G..l.......t...........h..........+............p.......c........s..........t...........G.............p..............l..............F..............s.s.........s...........................p..........A........p.......s.......l.........l...............c...............h.....L...h...p........c.h.c.p......h.....s..Vp.....l.p.h..p..s.p.l..h...sl.......................................tt...p...p....s...t............a......t....l....ps...............................ss...t......p....h....p...s...c.p...lllAoGG...............h....S.........h.....P...p...h.........G...u...os......G.a.c.lAc.phG..hslh..hpsu..sPh.........ph...........p......h............................ptLtGl.u.lp.sl.h.h....................................sptt...h....sh....ptshLF..T....HhG.lSGPulL...phSuah.........................................................p.............s.....................................l..p....l.s....l.h.P...s....h.s.......................l........tphL...p..pt..................p.t.......t...p.s....p.p....t.lps..h..................L...t...................t.....h.........L..Pc+lh.hhh.ph....t.......................l.........................p............tt.....htp.lstp..ph..p....t....L...sptlpphpl..pssGspshcpA.......V.....ThGGVsh....cE........ls..s+...TM..p..u...+h......lsG........L.aFhG..............EllDlsGhhGGYNhphAauoGasAup.s........................................................................................................................................................................................................	0	297	604	782
+2955	PF04588	HIG_1_N		Hypoxia induced protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4868 (release 7.5)	Family	This family is found in proteins thought to be involved in the response to hypoxia.  Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identified.  This region is found at the N-terminus of the member proteins which are predicted to be transmembrane [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.40	0.72	-4.22	59	931	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	520	2	533	819	723	53.40	27	41.59	CHANGED	s+cpPlVP....lGshussuslshuhhsh+.pG..spptSp+hhRhRlhAQuhTlsAlhsG	..............................t.hhs....................lu.hhussss.lhh.u..hhsh........t..pG............stphS....p+lh+hRVhAQuhslssllh..................	0	133	262	402
+2956	PF01355	HIPIP		High potential iron-sulfur protein	Bateman A	anon	SCOP	Domain	\N	21.50	21.50	22.50	22.50	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.70	0.72	-3.85	43	231	2009-09-11 11:04:45	2003-04-07 12:59:11	12	2	165	32	75	216	47	65.40	40	62.29	CHANGED	EsDspApALsYhpDAocs-..ps+a........sGQpCuNCthapup...sssshGsCsl..Fs...GKtVsusGWCsuas	........................EsDspAhALGYptDAocsD...ps+asp......tsGppCuNC.t.hapGp...tusshGsCsl..Fs...GKpVuucGWCsAas..........	0	17	38	55
+2957	PF00713	Hirudin		Hirudin	Bateman A	anon	Pfam-B_707 (release 2.1)	Domain	\N	25.00	25.00	34.70	34.70	20.30	17.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.43	0.72	-3.87	8	20	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	3	141	0	31	0	57.20	81	94.47	CHANGED	loYTDCTESGQNLCLCEGSNVCGcGNKCILGSsGccNQCVTGEGTPKPQSHNsGDFEEIPEEYL	VsYTDCTESGQNLCLCEGSNVCGpGNKCILGSsGccNQCVTGEGTPKPQSHN-GDFEEIPEEYL.	0	0	0	0
+2958	PF02098	His_binding		Tick histamine binding protein	Mian N, Bateman A	anon	IPR002970	Domain	\N	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.15	0.71	-4.39	13	345	2012-10-03 08:47:39	2003-04-07 12:59:11	11	3	20	17	31	355	0	139.90	15	70.32	CHANGED	hsshQDAW+slp.ssscsaaLhhRTacs-.s.hGpshpCVsspspchscsp+shp...........sshtYpN..sss.sphpshstplpshcptsa.shc....Nshphppt.....sspshsh.lhao...Dtst.Csl...........................lpsspsstu.ct..................................CELWh.psphspsh........................................................PssCptsFpths	..........................................................................................h...............tt.hhhhh..p..sh........t.p.......................t..hpCh.hp.h.h.p.h..ppp..tp...h.......................h..h.t.ah.......pp...t....tph.....ph.......ph.th...p.h..h.p.....p.t....sh...sh.............shh.phptt..............ts.shphplh.as....D.h.pp.Chl...........................lp.h...t..t..p.p....s....t.t....................................................CpL..a.htp.p.t..l..p..p..t................................................................s.p.p...Cp.hatt.C...........................................................	0	31	31	31
+2959	PF00977	His_biosynth		Histidine biosynthesis protein	Copley RD, Finn RD, Bateman A	anon	Pfam-B_1089 (release 3.0)	Family	Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes.  The enzymes in this Pfam entry are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. The structure of HisA is known to be a TIM barrel fold.  In some archaeal HisA proteins the TIM barrel is composed of two tandem repeats of a half barrel e.g. Swiss:P05325 [3]. This family belong to the common phosphate binding site TIM barrel family [4].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.34	0.70	-5.09	146	7930	2012-10-03 05:58:16	2003-04-07 12:59:11	16	27	3687	37	2167	8472	6948	229.60	33	89.54	CHANGED	cIIPslDl....ccG.+.sV...cGs..........pshp.ssDPl-...hApta..p..ppGA-cLthlDlsuut...ps+shph..cllc...c...l..scplt...lPlpVGGG....IRoh-slcpl..Lp.tG....s-....+Vslsos....Al.cs.Pcl..lpchucca.GspplVVulD..u+p...........G..............cVhhpGhpcs....oshcsh-hscchpchG..sucIlhTsls+DGThpGhs...l.ch.hcplsptl.s.lP.VIASGGsushc-lhplh.....ptGh..suslsupsh..apGphs	.....................................................................................................................hlIPslDl....c..cG......p......lV.........c.Gs..........................hps.h.p.s...s..DPlp...........hA..ptY....s....ppGA-..c.Lp..h..l...D....l..s..u..up.............ps...+..s....h....ph.....shlc.............p.........l....sppl............lPlpVG.G..G............IR..o............h...........--............l...........p...........pl...........L.p..s.G...........Ac.................+..V..slsos..................Al....p...........s.....P...p.h.............l.pc...h...sc......c....F......G.....s.....p..slVlulDs+t................G..................................hpV.ss.p.Ghpcs......oshcs.h......-..hspch......p..p..h..G.....s..u..c...l.l.l...T..s..h....sp...D.Gs.h..........s..G...h.s..........l...ch..hptl..............sp..t.......s.....p..........l.............PlIASGGsushpc.lhphh.........ptG...s..cuslsupsh..atuph..........................................................................................................	0	713	1441	1865
+2960	PF00815	Histidinol_dh		Histidinol dehydrogenase	Bateman A	anon	Pfam-B_1358 (release 2.1)	Family	\N	19.90	19.90	21.40	20.80	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.24	0.70	-5.84	16	3998	2012-10-02 17:28:28	2003-04-07 12:59:11	15	14	3598	8	1109	3262	5057	401.20	42	91.68	CHANGED	hcphltRsh.cssc.lhptVpsIl-sV+ppGDcAlhEaTp+FD..GVp.l-s...hVst-chpcAhctlsscl+pAl-hAhcNIcpFHtsQh..ptshslEsp.GVhsuphspPl-pVGlYlPGGpAshPSTsLMlulPAplAGsccIVlsSPPs.p.sGphsPplLhsAphsGlccIatsGGAQAlAAhAYG.TEo....lsKVDKIhGPGNhaVTAAKhhVps....tlsIDMPAGPSEVLVIADEsAsPcaVAuDLLSQAEHsssSpslLlTsS..cphAcclpptlpcQlppLs..Rt-.hlppuLs..aSsIllscslpEAl-hSNpYAPEHLhlpscsscp.llsplcsAGSlFlGsaSPESsGDYuSGTNHVLPThGaARpaSGLultoFhK+hTlQplTc-GhcslupsVhsLAcsEsLpAHtpAV+hRhc	...............................................t.....t......s.ssp..lppsVpsIlpsV+pcGDp.ALh-Yop+F.D....p...s..p.....h.........s...s...l..........cV..o..t..p-l......psAh...p...p.............l...s...sc...h+pAlphAhcpIcpaHpt.Qp.....ps...............h...p.............h...c............s....t......s.....G.....lh.hsphhpPlp.......pVGlYVPG...G...p...A...shPSoVLMsul...P..A+lAGV..cclVhsoP.........P......................h...................G.........................ss....tl....L.sAA.p.l.s.GV.sc......laplGGAQAIAALAY......G......T.....E.o.......................ls+VDKIsGPGNtaVstAK.RtVhu..............tV...uI.D.M..AGPSElLVlA...D...p.s..A..s..................Pcal.AuDLLSQAEHss.t.u.ps..l.LlT.ss.........tplAcpVp.ptlpc.Q.L..t.p.Ls............R.t.-..lsp.puls....put.lllscs.l.s.pulpluNphAPEH.Lplps.....p...ss...p..p...hl.sp.lcsAGulFlGpaoPEulGDY.s..u.GsNHVL........P.........TsGsARhsSuLultDFhK+hol...p..h..o.c.pu.....h.pp.l.u.psltp..LApsEsLs.AHtpulplRh.....................................	0	350	717	947
+2961	PF00125	Histone	histone; 	Core histone H2A/H2B/H3/H4	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.06	0.72	-3.86	64	18172	2012-10-10 12:36:46	2003-04-07 12:59:11	19	47	9743	705	4298	10642	208	64.10	53	50.27	CHANGED	psphthhphsltRlh+plppp..........h+lsupAhhhlppslEshhtclhpcAs.hhupcs+RhT..lts+-lphAh+hp	.......................................STELLIRKLPF.Q.R..L.V.R...E....IAQDFKoD.................LRFQSoAl..h.A.L.......Q..........E....u......sE...A...YL..V.u...L.FE..D.....o...............s..L.......s...A....h..H....A..K....R...................................................	0	1432	2046	3176
+2962	PF01230	HIT		HIT domain	Finn RD, Bateman A	anon	Prosite & Pfam-B_8474 (Release 8.0)	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.27	0.72	-3.46	26	8213	2012-10-01 23:45:21	2003-04-07 12:59:11	18	43	4728	105	2350	6615	3709	96.10	27	65.13	CHANGED	ptEhsupllh-s-hshAFhDhpPpsssHhLVlP+p.p..lsplpshs........ttluplhhhspcluptlph.....................ttpuhphshpsGtpuGQsVhHlHlHllstcph	................................................t..phss.hl.a..c..s...-..h.s.h...A....F...h...D..l...p.....P..h....s..s......G........H....h...L.....l.....lP+p..c......h.s.s.l.t.-.ls...........................tpt...h...s.c....l....h..t.h.s.pc.l.u.c.t.l...t.t............................................................................t....p.G.h.p...l...h..hN....s..s..t..t..u..G.Q..s..V..h..H..lH..hHllP+h..h........................................................................	0	773	1489	1980
+2963	PF00816	Histone_HNS		H-NS histone family	Bateman A	anon	Pfam-B_1651 (release 2.1)	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.19	0.72	-3.48	151	2937	2009-09-12 23:38:08	2003-04-07 12:59:11	16	8	1220	14	554	1580	133	100.10	31	80.49	CHANGED	pcLpphhpclp.........pphppt..cppc.pppsltpl+phhpp..hG..lo...hp-L......................hststt..............sppp+s.sss..KY+pPps.Gp..TWoGRGRpPpWltshh..........spGcpl	..........................................................t.pL.chlccLc...........cptptt..c..hpE..cpc....tlpphp...c...hltt..G..Is...spEL............................................hsssts........tstt+R.sspP.A....K.Yc...s-s.Gc..TWT.G..pGRsPphItpshtptt......................................	0	67	192	380
+2964	PF01870	Hjc	DUF50;	Archaeal holliday junction resolvase (hjc)	Enright A, Ouzounis C, Bateman A, Dlakic M	anon	Enright A	Family	This family of archaebacterial proteins are holliday junction resolvases (hjc gene) [1]. The Holliday junction is an essential intermediate of homologous recombination. This protein is the archaeal equivalent of RuvC but is not sequence similar.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.87	0.72	-4.38	16	183	2012-10-11 20:44:43	2003-04-07 12:59:11	13	2	153	24	103	289	78	92.00	30	64.17	CHANGED	shERELlchLpccG........................FAVlRusuSsuu.......DllAspssh.hLsIElKsopct..+lYl........cp-clcpLlcFuc+F...GupPhlAlKh....scsW+Fhssps	.....................................p.hERELlphLc.c.pG.........................Fu...V..l......R...us...u.Ssus..........................hsDllA..scssh..hlsIE...sKosppp...plh.l..........pp-plcpLhpFucph...........Gu....pshlA.lKh...ttptWhhh....p...................................................	0	26	59	85
+2965	PF02110	HK		Hydroxyethylthiazole kinase family	Mian N, Bateman A	anon	IPR000417	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.57	0.70	-5.20	9	2596	2012-10-03 06:25:16	2003-04-07 12:59:11	10	9	2292	46	490	2628	261	239.80	38	87.31	CHANGED	Lpcl+pppPLVHsITNhVstNFoANsLLALGASPlMuhsh-Ehp-hA+IusA.LlINIGTLss..hcuhhtAscsAp-hspPllLDPVGsGATphRpcssh-LL.phthusI+GNsuEIhuLsGhs.tts+GVDospuuss..s.ltsspplApchsslVlhTGchDhVoDGpp..shslpsGsp..................Lhs+lTuoGChLuuVsAuFhAl...pssLhss.hsAsshYplAu...ppAstcspus.....GSFhsphlDtLhpLstE	................................................................................................................phl+ppsPLlpshTN.Vs.tsh.........sANs.......LLAlGASP.sM.u.p.s.scEs..p..-h.s.p.l..A..s...A..L.l..IN..lG.............T.L.os..p..p.h...puh....ht.As.c.t.A...p.p..s.s..h.P..h.VL.DPV.......u............s.......G.......A.....s..........s...a...R.......p.......c.......h.s........p...cL..L.....s.....h...+.....s...s...........lI.R...G.N....A.SE...Ih....u.L............s...........G..............h..............s......s...........t............u........+...........G.V.........D.....u......s......s....s....s........t..s...................s...l........t.............h....App....h...u..p....c............h.......s.........s.......l....l...l....l..T.G........p........h......D.......h......l....s.........s...u.............pc............s.h..s..l..p.s.Gss....................h.h.s..+...l..T.......GTGChLuAllAuF..h.uht...................ps....s........h......ss......ss.A..s..s.hh.sl...Au......................Eh.A.....s...t...c...s....p.Gs..............GoFpsthLDtLapls.........................................................	0	163	312	412
+2966	PF03865	ShlB	HlyB; 	Haemolysin secretion/activation protein ShlB/FhaC/HecB	Finn RD, Henderson I, Moxon SJ	anon	DOMO:DM07489;	Family	This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein [1]. 	19.90	19.90	19.90	19.90	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.24	0.70	-5.74	2	1287	2012-10-03 17:14:36	2003-04-07 12:59:11	8	9	664	2	267	1255	50	340.50	24	65.32	CHANGED	GDRhVNopLLFPtlcGpPLKLspLDQGLDQANRLQSNpsplDILPGpplGGSVI+LpNQ+tpPWhlshuoDNYGQKsoGRWLhRssAoLDSPhGLSDFVSLNAN.Th-NPspRaNRAYTLLYSlPYGuFTFSuFuSaSpYp.HQpL.ppsVpLaGpTpQhGlRuDYsF.RspcQIDoLshQlTaKRIcNYFpplRL-lSSPpLThhELuhsHLQIlPNGVhSsNLSVEpuhsWhGAtcpP..sp....D.pFTKsKLFsNh.QRhpLhcuTa.hNshFhGQYS+DsLPGVEWLSLTD+sAlRGFspST.SGDNGhYLpNTLShsapLstholTPRlGsDlGplh.+ts.pGWpuuhGlSoGhslpYQpA.lDLEVu+G.lL...oNpspscDPsQlLs+FSYhF	............................................................h.ht..........h..P.hh.t....G.cl....Lsl+-lEQGl-p.hp.Rls...........s.....p.sp.hpl....hP.....u....p.....p...s.....G....t.S......lhl.p.h.p.p..s.c...h....ph..s..huhDssG..p..cs..T..Gchpss..ss..l..sh-N......shuL..s.D.....h.......l..s.........h.....s.......p...s.......h........p......t.....t....t........p....p.....h.....s........p..........s........h.....s.ht.Y..S....lP..a..G..h..a..p.hs..h...h.s..h..sp..a.p....h...t..h...t...s.....t.....s..h.....p..h..p..G..p.o...p..p..h..shp..h..s..+...ll..h...R.st..p.p..+t.....shth....pl..p..+..ps..........ps.......a..l....s....s...s...c...l.p.h..pp....p.p..h.s..s...hph..G.l....s...a...p.p...h..h...s..t...u....h..h.......s..h....slu..a.p....pG.h.s...h...h..G..A....p...t...s.....s....t........t.....t...............................t........s.....p.....h.....p..t...h.ph..s...h...s...ht..h...s.......a...t...l...h...p...p..............ht.a..ss..t..ht...uQa..o..t..s..s..L.hs.t-p.holGuchoVR.GF...c.c.p.s.l.s...u-p.Gha....h+.N....-..L.........s.....h.......h...............s................t.......h.............h.......h.......u.h....DhGt..l................................................................................................................................................................ss.hh.h.hh.h.h............................................................................................................................	0	31	115	195
+2967	PF02794	HlyC		RTX toxin acyltransferase family	Bateman A	anon	Pfam-B_1230 (Pfam 6.0)	Family	Members of this family are enzymes EC:2.3.1.-. involved in fatty acylation of the protoxins (HlyA) at lysine residues, thereby converting them to the active toxin. Acyl-acyl carrier protein (ACP) is the essential acyl donor.  This family show a number of conserved residues that are possible candidates for participation in acyl transfer. Site-directed mutagenesis of the single conserved histidine residue in Swiss:P06736 resulted in complete inactivation of the enzyme [1].	25.00	25.00	25.40	25.10	21.20	24.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.69	0.71	-4.56	29	386	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	293	0	46	249	70	134.70	34	84.55	CHANGED	phLGtlsWLhhpSPhHRcaslu.lttpllPAlphsQatlhp..cs........................shPlAFsoWAhLo.-sEt+alpssppLhsp.DWsSG-+hWlIDalAP..FGc.....sptlh+pl+cp.Fs...sphh+slRhchsuppttplh.ht.......................lp	...........hlGtlshLhhpSPhH+p.asls..hthpllPAIptsQaslhp..cc........................Gh.PlAasoWAhLs.-sEs+aLps......sp......p......Lhsp.DWpSG-.RhWllDaIAP.F..Ga.....sptl.hchhRp.c.Fs.....tph.hRulRhc.sspp.tplhphph...hsh...................................	0	7	23	37
+2968	PF00529	HlyD		HlyD family secretion protein	Bateman A	anon	MRC-LMB Genome group	Family	\N	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.58	0.70	-5.11	44	15364	2012-10-02 20:27:15	2003-04-07 12:59:11	15	41	2231	47	3183	22645	3068	262.60	18	71.90	CHANGED	tsplpspluGhltclhsc-GstVctGplLhplDssshpush......ptpuphttspt...psphhttthpphpshhtspth...............tppptssthtthppshhpsp.....hptsplppuptshpttpsshphs...............sthppstsphtstlss.......tspshhshsplpphhhphppsptt..t.htssspu.hhtt..t.ptlphsptht.....sstslhshl.hpphtlctphtpsphctht.s.pspltsshhsts..hhhpGsssss..h..hhshsssspthts..plhssshsphspthsVclths....ththsspshhsGppshl	....................................................................hpltspV.uG.h.....l..h..p.l.......h...p...-..sp..h.V.....ct......G.p..h.Lh.......p.....l........D.......s.......t.......s...h..pst..ht..........................................pA..p..u.....p....l....t....p....s....p.....t............................t....h.....p.............t....t...........p.....h.....p....p...hp...t.....h....h..t....t....tth..........................................................tpp.t...h..p..p..t.......t...............p.....p.....s.......h...p.t..................................h...s.....p..t.......p..l....p.......p.......u...c.......h.......s...h....t...h.....s....p...s...t..h..hs................................................................sth...s..t......t.t...s...t...h...t...s.h..lps...............................ps..p.h.h.......s.......s.......h...s........p....l......p............h..h....l....s.......l....p....p..s...p...................................................h..p.....u....s.t....s..G..............h.....h..........t......t..........................h.....s...l.......ph.sthss...................ssts..h...h...s....h....l..........h....p...s...h....h.......l...s...s..p.h.......t..p....s.......p......l.......pt......h......h...........s.......s.............p........s...p........l..h....s.s...h.hsp............hh..h.p..u.th...s...........h.........hs.t..t.....s..h.........p...........h..s.................s.........s....h....s....h.......p.....h..s..p.t..h.s.l...p.h.t....ht.......................h..s.....................................................................................................................................................................................................................	0	714	1599	2379
+2969	PF03201	HMD		H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase	Mifsud W	anon	Pfam-B_2929 (release 6.5)	Family	\N	20.30	20.30	22.00	72.70	19.80	16.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.20	0.72	-4.07	13	59	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	31	6	38	60	0	97.90	47	28.43	CHANGED	A-LlusVsDMuSsVTAlshAGlLsYhsssTpIlGAPtchspp.sh.oLpplAuLh-ssGlcsh.cuLsPcsLlsoAcSMphssps..-.LssuLclLEch	..AcllusVsDMGShVTAlshAGlLsYhsssTpIlsAPtchsph.sh.uLpplsuLhcspGlcsM.csLsPcsLlsoAcSMphssht..-.Ls.suLclLcc.......	0	10	18	28
+2970	PF01101	HMG14_17		HMG14 and HMG17	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	21.60	21.40	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.73	0.72	-3.29	18	482	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	149	0	153	417	0	80.60	54	86.60	CHANGED	PKRK.......stssstssKpEPpRRSARLSAKPAPPKPEPKPKKsusKcK............ssKscK.uAKGKc..-ptpptsK-ss...suENG-sKs-E..s.ts-ustspc	.....................t+.........t.sspthsKpE..Pp..RRSARLSA............K.PAPPKPEPKPKKAusKcp.................cK...ssKGKK...tc.ustu..p.ctss...PAENG-sKo-p...s.ts-t......................	0	9	13	36
+2971	PF00505	HMG_box	HMG_box; MaoC_dehydrat_N;	HMG (high mobility group) box	Finn RD	anon	Pfam-B_8 (release 1.0)	Domain	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  --amino -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.03	0.72	-3.71	31	8695	2012-10-02 14:16:02	2003-04-07 12:59:11	14	175	1353	52	3772	8773	263	66.20	29	17.82	CHANGED	PKRPhoAahlatp-tRtpl+p-sPshc..sspluKtlGctW+sLstc-Kt.Y.ptApct+pcaccphspYc	.......................................KRP.h..sA.ah.la....t....p...c..p.......R........p....p............l.......t........t........p.........p.........P............p............h.........p.........su.........-..............l......o.....K.hL..G....p..p...........W..+..........t..L..s.cp........-.K............p.....ah.c.c.Ap.......c...h+t..pahcphssYp...................................	0	1189	1695	2729
+2972	PF01154	HMG_CoA_synt_N	HMG_CoA_synt; 	Hydroxymethylglutaryl-coenzyme A synthase N terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.06	0.71	-4.71	4	1680	2012-10-02 12:25:54	2003-04-07 12:59:11	12	15	1444	28	478	1426	215	165.20	41	40.45	CHANGED	WPcDVGIlulElYFPoQYVDQuELEKaDsVssGKYTlGLGQs+MGFCoDREDINSLCLTVVpKLMERsslsassIGRLEVGTETIIDKSKSVKoVLMQLFpESGNTDlEGIDThNACYGGTAALFNAlNWIESSuWDGRYAlVVsGDIAIYspGsuRPTGGAGAVAMLIGPsAP	...............................................h....lGIctlthahPs.....YV.c.....hs.....-.L.....A.........c....s....R......slD....ssK.a..p...h...Gl...G...Qpchulss..sEDIlo.hussA.upsl.l.....s.c..p........-.t.p.pIshllV...uTESulDpSKu...s..us.h....l....p....pL........Lul...............p...s.......s....c.uh...E...hKpACYGuTAALphAhsalp..sp.s...........s......sc...c....sLVl..A....oD....I..........A............+.Y...........u...h..s.........s...........u.........E.P.T.....Q.....GAGAVAMLIuts..s..................................	0	147	269	383
+2973	PF00682	HMGL-like		HMGL-like	Bateman A	anon	Pfam-B_71 (release 2.1)	Family	This family contains a diverse set of enzymes.  These include various aldolases and a region of pyruvate carboxylase. 	21.90	21.90	21.90	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.11	0.70	-4.71	20	12580	2012-10-03 05:58:16	2003-04-07 12:59:11	14	57	4555	111	3825	10439	6963	236.80	26	43.97	CHANGED	RDGEQuhtss.holpcKlpIActLschGlc.IElG.............hsssuts-hctlcslsctlts...uclsslsR.............sstc-lctuhc.h.ssGsspl+lhlssS-hhhphplppsht.shcpspphlchA+phs.cV..........plusEDuuRsshsalhclsctshsA......GspplslsDTVGhhsPpphtchlptlpppls....s.lulHsHsDhGhAlANolsAlpAGAspl-solsGlG......ERAGNsuL.Eplshulcstt	...................................................................................................................................................RDGpQu........hss..h....s.....scc+lpl..........s....p..........t..........L..s..c......h.....G.....l.p......l...Esu...................hshs.u........t....s.........s.....h.....c.t..l.....p.....p......l...t.....c.....t....h..hp...............spl....p...s...L...h...p.............................................s.s...p....p.........l....c....p....s.....h....c..........h.........................s....s........h....s....h....l...........+....l.a...s...ussp...............................h.........t.........h.......s...................t...t......l...c.t...h......t....p....s.l.p..h........s......+.p...h.....s...h..ps................................ph.u...s....p......s...t....s......t....t...s......h...p.....h...h.h..c.....l..s......ct.h.h.ph...............G.s..p.h.l..slsDT.......s.......G.......h.......h.......p........P.......p.......p..............ht.......c.......l.......l.p...t.l.p..p..p..ls.........................h.lul.Hs.H....s..sh........Gh..A...........lA.s..s..l..s....A....l....c....u..G..............sc....t.....l...-..sslsGhG.......................tp..sGNssl.EsllhsLph..t.........................................................	0	1234	2475	3280
+2974	PF00423	HN		Haemagglutinin-neuraminidase	Finn RD	anon	Pfam-B_171 (release 1.0)	Family	\N	20.40	20.40	20.50	21.80	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-12.63	0.70	-6.22	21	2456	2012-10-02 00:45:24	2003-04-07 12:59:11	14	2	198	58	1	2086	0	439.80	33	94.13	CHANGED	lhshlshlLullsllhhhshplpphshsssphpphhps.hulspsIcptsccltt.....lpPhhphIsspVuhplPtplsphtp.l.......................psp............................lsctC....................shspsptshhsh.psphhpsl..shpshhhsssssh.sshs.psphp.h.ssohl..ssssshsu..Clp.PshulupslauYoaslhpssCpct......spshphhplGhlpspusthPshpsssthshspsssh+sCSlsssshthhtLCohssssphp-huoss.pslhlshLsltGphpspchpss.hshc.....sastLYsosGsGlhhssplhFhsaGsls..............pstpspupChtstCpspstphCNpu.hsshhus+hhspGllplslsh..stpsplpltolssshhhhGupu+Lh.....s.hhhYpposuWhohs.hstlsls..sshs....lphsspshs..oRPGssp..CthsspCPt.CloGlYsDsa.Lss........shphlsushlsSpps+tsPhhshssspshshhh.lp.sspspsshooosCF..sapp+laChphsElsssshsshpsh.hhspl.hsC	.................................................hhlhlhhl.lhhl..hh.hs.hhhphsh.....p...........pp..thsp.lpct..pl.........slhp.Ihcp...l.......slp.P.th.ph.p.l........................pt.......................................hs..h....................tsss..pt.hss.h....hss.....h....ltsh..ph....h.s.hp..h.sshh.........t.shl..sh.hotsh..ssp..sh.hopshYshTa.l..sshpsc......sp.hphhtlGhl+psu.shshhphhp.h..s.spshpsC.luhs.LthshLCpt.sshp....uSst.sshhhspLGh.sphpppphpssh.ht......shsthY.ustpGhhhDspshasV.sshp..............p.ppt.psC.pp..psh..thspss.h.shhss+hsp.ulLolplsh..olt...phhls.s.sslhhhGuthclh........h..ppss.sWho.s.hhshsls.h.ssh...........h.sP.hhs.......+...u..u.s..Cthssh.....lsuhhsssh.l...h......spshphVhuTh..sp.t+hssh.sh.s.hshshhh.hp.s.pshs..hp..pCF..shspchaChphh.htss..sthh.h..hsthhh................................	0	0	1	1
+2975	PF04814	HNF-1_N		Hepatocyte nuclear factor 1 (HNF-1), N terminus	Kerrison ND	anon	Pfam-B_2624 (release 7.6)	Family	This family consists of the N terminus of homeobox-containing transcription factor HNF-1.  This region contains a dimerisation sequence [1] and an  acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) [2].	28.40	28.40	29.10	28.60	27.70	28.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.29	0.71	-4.18	9	283	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	52	22	104	212	0	171.40	47	37.26	CHANGED	MsScLotLQpELLtALLpSGloKEsLlpuLs-ht......................Pthphs-p.hth..hshstutsp........th..uhGcs..................................chotDEs....S-DG--..sPPIhKELEsLusEEAAcQ+......ulV-pLLpEDPW+sAKhlKSYMQQHNIPQREVVDsTGLNQSHLSQHLNKGTPMKsQKRAALYsWYVRKQREltpQ	................................................................................Q.-LLttLhpoGhoKc.llpALtpht................................s.....st.tsh...ht.ut............................p.s......................................................+hSt-.cs...........sps.up..ca.s.....P..Pl....hp....c..h....p...s.h....s.....s.E.EAu.cpc........scV..Ec..LL..pcDsacluchIKuYhQpHNIPQREVV-sT..GLNQSHLSQH..L.NKGTPMKsQKRuALYsWYl+KQpEl........	0	17	29	54
+2976	PF04813	HNF-1A_C		Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus	Kerrison ND	anon	Pfam-B_2624 (release 7.6)	Family	This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform.  Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing.\	\	The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms [1]. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) [2].	27.30	27.30	28.70	35.50	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.96	0.72	-3.71	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	34	0	20	47	0	81.80	65	14.36	CHANGED	llToDPEuHTDSuIcEPSS......l.sQD.osILHLQSu.RLSPsPsVSSuSLlLYpsSsSoEoH.SHL.LSSoHusI-oFISTQMASSo	......................VFTSDoEAsSESGLHsPuSQAoTlHlPSQD.suuIQHLQPuHRLS.sS..........PT..VSSSSLVLYQSSDSoNGH.SHL.LPSNHSVIETFISTQMASSS.	0	1	2	5
+2977	PF04812	HNF-1B_C		Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus	Kerrison ND	anon	Pfam-B_2624 (release 7.6)	Family	This family consists of a region found within the alpha isoform and at  the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1.  Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative  splicing.  The C-terminal region of HNF-1 is responsible for the  activation of transcription [1]. Mutations and polymorphisms in HNF-1  cause the type 3 form of maturity-onset diabetes of the young (MODY3) [2].	25.00	25.00	54.90	52.20	20.40	21.20	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.83	0.70	-5.10	11	156	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	43	2	50	130	0	219.60	56	42.10	CHANGED	AMDsapus..uss.s.hLsp.s......oPpsu...s.th..u.........................lRYSQpussEssoSos.ups.spu.....osLpQVSPsuL-PSHoLLso-sKh.IusSGGsLPPVSTLTslHSLstss....Ht.tQQsQNLIMssLPuVMuI....................s.uLsooQuQSVPVINSVGuSLTTLQPlQF.SQ......QLHsshQQPLhQQsQ.SHMu..QsPFMAThAQL.ssH.MYS.KsEssQYsHoShhsQsMVITDoosLuTLTSLouoKQ	...................................................AMDsYsus..s..s.sPhLsttSs....t.Pssu....sP...s.Khp..G.........................VRYuQ.ussEssusso.Stt...stshV.T.sposLpQVSPsuL-Pu..HsLLSs-uKh..lSsoGGsLPPVSTLTslHSLp........t.sQQsQNLIMssLsGVMAI.......................s.uLsooQAQSVPVINShuuSLssLQPVQF.SQ......QLHssaQQPLMQps..SHhu..QpPFMAshsQLQssH...hYuHK.EssQYoHouhhPpsMllTDTsslSsLsshosoKQ.............................	0	2	6	18
+2978	PF01844	HNH		HNH endonuclease	Bateman A	anon	[1]	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.73	0.72	-4.09	92	7400	2012-10-05 18:28:12	2003-04-07 12:59:11	18	79	3428	3	1824	6263	3802	47.60	26	18.89	CHANGED	Cp..hCspph...........thplcHIlPhp....p..uGpps.....hsNLhslCpp.Cppp+psc	.....................................Ct..hC..s.t..h........................thplc.Hlh.Phs...............p........GGtss....................hsN..lhhlC....tt...C.Hppcpt..................	0	538	1239	1594
+2979	PF01848	HOK_GEF		Hok/gef family	Bateman A	anon	Swiss-Prot	Family	\N	21.60	21.60	22.80	22.50	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.01	0.72	-4.63	41	1852	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	385	0	46	440	2	42.80	47	78.31	CHANGED	+thlhsLlllClTlLhFshlsRcoLCEl+l+pG.spEluAhLAh	.......KhtLlulIVlClTlLsFsLll+cSLCEl+l+pt.shEhsAhLAY..........	0	6	9	26
+2980	PF05102	Holin_BlyA	holin_BlyA; 	holin, BlyA family	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	BlyA, a small holin found in Borrelia circular plasmids that is  encoded by a prophage.  BlyA contains two largely hydrophobic  helices and a highly charged C-terminus and is membrane  associated [1].	21.10	21.10	22.00	21.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.02	0.72	-4.25	3	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	33	0	3	53	0	59.30	54	93.80	CHANGED	MDTIpIs...-FLlsLsNIKLItLhIFIollILullLllKPllKDhLoILIuKIhKNsNcKEKc	..........MDTIKlT...EhLINLNE...IKLIuVMIFlTVllL.GsLILLKPLLKDILoIl..IGKlFKNuNsNsp.................	1	2	3	3
+2981	PF05204	Hom_end		Homing endonuclease	Studholme DJ	anon	SCOP	Domain	Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life.	21.10	21.10	21.10	21.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.42	0.72	-4.11	24	211	2012-10-03 01:41:40	2003-04-07 12:59:11	9	23	116	23	55	250	50	102.50	30	13.28	CHANGED	slPpaLto-slplREsFLAGLlDS-GhVccptt.....ssolpTh.polhpGlVplARSLGlpsoVss...cptphctpsVppp.s........YslslusussLpuVLutCusscppts.........tthh	..............IPphhhppshplR.uaLAGLIDSDGhsscptt.....phslpohpsolhcsllplARSL.Glssssss...c.th.h.hptsph............Ysh.h...t.t...t...s....h.t.s...............s.hhh..................................	1	5	22	47
+2982	PF05203	Hom_end_hint		Hom_end-associated Hint	Studholme, DJ	anon	SCOP b.86.1.2	Domain	Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce [1] revealed two domains: an endonucleolytic centre resembling the C-terminal domain of Drosophila melanogaster Hedgehog protein, and a  a second domain containing the protein-splicing active site. This Domain corresponds to the latter protein-splicing domain.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null --hand HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.37	0.70	-4.60	37	308	2012-10-03 10:25:13	2003-04-07 12:59:11	11	40	197	12	58	405	104	284.60	23	42.25	CHANGED	CauKGTpVlMuDGopKslEclplG-tVMGpDGpPR..cVhsl.s+Gp-pMYclppps.p..................shhsasCsusHhLVL+ss.th....p..th.....................t.R....lsp.hptsa..p...u..tt.thhpph.ts.sscphhpaslpA+Dhs.tLssplRpso...pthhsPlhhtpt.hsphltstt....p.s...s..huYlLGLWlGsG.htcpsphshsopD.tplh..pplpphup..hhslp.phtptp.shh.t..........................................................................h......t..ht..............................................................................................................................................tshspsN.hhptlh.phGhhp........phsKpl..Pphhhs-shphREtFLAGLlDocGhl..pt......psslpsh.pplhpslltlARSLGlpsslspcptp...hthtt..............athp.lssssshhssLshsttspp.htstspth.ct...htFphhE.hpps-aYGlTl..-sD+paLLushhVlHN	........................................................................................ChstGT.lhhuDGs..cslcslphG-hlhG.D.....G....p.....s+......cV....hsl....s....p...Gh-..p..hY..plp.ts...........................................................th.shsssssH.Lshh..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	13	33	53
+2983	PF00046	Homeobox	homeobox; 	Homeobox domain	Eddy SR	anon	Unknown	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.63	0.72	-4.35	182	25115	2012-10-04 14:01:12	2003-04-07 12:59:11	24	290	1497	161	11025	24665	26	54.40	35	16.80	CHANGED	++pRTsaospQlptLEptFp...p..spYsstpcRpcLAppL.....sLs-ppVplWFQNRRtKhK+	........................................++.Rs.s.a..o.p.t.Q......l..t..t.L.E...c...tFp.................p...s...pY.......st....t..c...........R.t.clA.ppl........................sLo.c.....p..p..V...........p.........l......W...........F..Q.N.RRhK.++......................	1	2391	3737	7103
+2984	PF00742	Homoserine_dh		Homoserine dehydrogenase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_459 (release 2.1)	Domain	\N	22.90	22.90	22.90	23.30	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.90	0.71	-4.60	147	5558	2009-01-15 18:05:59	2003-04-07 12:59:11	14	32	4234	19	1325	3990	2377	185.10	37	33.91	CHANGED	Pllcslcps.LsGsclpplpGIlNGTsNaILopMp....p..GhsFpcsLc-AQchGaAEs.DPstDlsGhDsApKlsILAphshGhpl..s.hs-lthcGIsslsht.......................clphA.pchGhsl+Ll..................uts..ch............ttth.pspVpPphlspscsLAp.lpGs.Nulhlps-hh......uslhlhG.GAGstsTAuuVluDll	.............................................................PllcsLpph..huuDcI.....ppltG.IlNGTsNaIhschs..................pt...GhsFs-slppApp...hGauEs.DPpsDl....sGhDsA+Kl....sILAph..........h..G..h........p.l.......p....hs.-l..t..l.E..G.ltslshp................................clp.hA.cc.h...G..h.sl+hl........................uhhc........................tshpscVpsshlsps.+PLAs.Vpss.NA..........lhlpuchh......ssl.hh.....hG.GAGstsTAuuVhuDll..................................	1	417	834	1118
+2985	PF00103	Hormone_1	hormone; 	Somatotropin hormone family	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.21	0.70	-4.99	17	1608	2012-10-02 01:28:15	2003-04-07 12:59:11	15	2	560	24	164	1561	2	156.40	32	94.64	CHANGED	LlhSshLLsp.....suSsPsss..........LpcLFppAsphucphapLusphas-F-ppahptpt.......hhpts.......shCHTsolpsPps+-pspphstpcLL+hslhLL.SWppPLhhLss-hpsh.ts..stsllo+Ap-lpcp.cpL.pslcplhp+l...stpphp.h..tasphu...tscc-p+hhshYsLhhCh++Ds+Kl-hal+lLpCRhhhp....C	.............................................................................................................tpLhs.sh.hsphla.Lu.tchhp-F.....-c..p..hhsppp...................h.p.............shChopol.s.PpsK.ccs.Qp.h.o......hc.LLchuhhLlpS.W.tPlphLs....t......ts..s......h.t..p...cl..tht.L.......cuh..h...th.....................................h.h..ths.............pptlht.at..Llt..Ch++D.cKh-saLplhpCR.......C.......................................	0	6	15	61
+2986	PF00123	Hormone_2	hormone2; 	Peptide hormone	Sonnhammer ELL	anon	Prosite	Family	This family contains glucagon, GIP, secretin and VIP.	21.20	21.20	22.50	21.20	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.58	0.72	-6.64	0.72	-4.09	56	842	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	138	23	275	773	0	27.80	39	34.80	CHANGED	HuDGoFTs-ho+hL-phuA+cFlphLhs	.......HuDGhFTssYS+hLcphus+calphLl.....	0	10	29	91
+2987	PF00159	Hormone_3	hormone3; 	Pancreatic hormone peptide	Sonnhammer ELL	anon	Prosite	Family	\N	22.40	22.40	23.10	22.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.54	0.72	-3.94	21	274	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	120	32	90	268	0	35.70	61	41.61	CHANGED	hPscPc..tPG-sAssE-..LupYhssLpcYlNllTRpRY	.........YPsKP-..sP.G-DAssE-..hA+YYuuLRHYINLlTRQRY.	0	8	14	32
+2988	PF00220	Hormone_4	hormone4; 	Neurohypophysial hormones, N-terminal Domain	Finn RD	anon	Prosite	Family	C-terminal is in hormone5	17.00	17.00	17.00	17.10	16.90	16.90	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.55	0.74	-5.72	0.74	-3.80	8	197	2009-09-11 03:36:00	2003-04-07 12:59:11	12	2	104	0	51	205	0	9.00	83	7.31	CHANGED	CYIpNCPhG	CYIQNCPhG.	0	3	5	25
+2989	PF00184	Hormone_5	hormone5; 	Neurohypophysial hormones, C-terminal Domain	Finn RD	anon	Prosite	Family	N-terminal Domain is in hormone5	25.00	25.00	25.00	31.40	21.80	24.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.37	0.72	-10.76	0.72	-3.44	36	207	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	109	29	60	232	0	77.00	63	55.90	CHANGED	RpChsCGPGs+G+.....CFGPsICCG-pl......GCalGTsEoh+CtEENYL..soPCps.GG+sCGs.t....uG+CAAsGlCCssEoCshDssC	........RpChPCGPGs+GR.....CFGPsICCG-pL......GCalGTsE..shRCpEENYL..PSPCpu.......Gt+sCGS.............GGRCAA...sGlCCss.-.uCshDssC................	0	6	8	30
+2990	PF00236	Hormone_6	hormone6; 	Glycoprotein hormone	Finn RD	anon	Prosite	Domain	\N	25.00	25.00	25.60	25.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.49	0.72	-4.17	10	201	2012-10-02 16:54:34	2003-04-07 12:59:11	13	2	150	10	30	185	0	91.40	69	81.48	CHANGED	aPcs-hss.GCsEC+L+ENphFS+.GAP.IYQChGCCFSRAYPTPLRSKKTMLVPKNITSEATCCVAKphhRVTVhsslKlENHT-CHCSTCYYHKS	...................aPss-h....GC.EC+L+ENphFS+...GuP...lYQCMGCCFSRAYPTPlRSKKTMLVPKNITSEATCCVAKphp..+...spV..h...s.....l+.lcNHT.......-CHCSTCYYHKs.................	0	1	3	11
+2991	PF04617	Hox9_act		Hox9 activation region    	Kerrison ND	anon	DOMO:DM04544;	Family	This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].	20.60	20.60	25.40	22.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.56	0.71	-4.11	29	299	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	74	0	96	259	0	167.00	38	65.14	CHANGED	MSoSGTloNYYVDSlIspEs..EDhh.usRF.ssushssss.......R.su.s.s-pu.....-asSCoFtsKssVFuuS.WSsl..ps.pssss.sulYH.....PYh.....t.Qstl..suuDu...RY..lRSW.L-Phsssl.shsGh..ssspp.Y...ulKPEsl.u+ts.-s.shcspshhh...s-atssusssspcp...tppttstspssspsp......pE-K....pplDP	..................MSsoGsloNYYVDSllsHEs..E-lh.u.......uRF.ssGs.h.stss.......R.su..l..s-.ps......-FsSCSFtPK..ssVFuu.S.WusV..ps.pssss.s.uVYH........PYs.......p.Qs.l....susD.u.RY..hRSW..LEPhsusl....uhs..............Gh...s......su.....+p.Y...u...lKP-......sh...upps.-s......ts.ps.sh.....s-Yhhsssss.cpp....st.ts....scs.stsct.....pc-K...thD....................................................................................................	0	4	13	43
+2992	PF01856	HP_OMP		Helicobacter outer membrane protein	Bateman A	anon	Pfam-B_395 (release 4.2)	Family	This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.15	0.71	-4.41	33	2354	2012-10-03 17:14:36	2003-04-07 12:59:11	12	2	57	0	129	2284	1	164.40	30	37.09	CHANGED	ulplGYKpFFs..p....p+hhGhRYYGFaDYsauthspppht.s...............................shhTYGsGsDlLaN..h.hspppt.......................................shGhFuGlplAGsoWhsstt.thth..............................................psphpsotF........QhLhshGlRhshs...............t+pulElGlKl.Phltppah........................sshshps..pa+R.auhYlsYsasF	.........................................hplGYcpFFs.........p...........p..+..hhGhRYYG.Fa-Y..s.......auhht...pp.th..t...............................................................................shhoYGs.GhDh..LhN.....h..hssp.pt..................................................shG..lFuG....ltluGs....o.ahssptsphts..........................................................................t.phpsstF........QhhhshGlRhpht...........................tcpshElGlKI.Phl.pp.phh......................................sshsh.ph...p.a.cRhashYhsYsasF..................................................................................	0	39	93	129
+2993	PF02521	HP_OMP_2		Putative outer membrane protein	Bashton M, Bateman A	anon	Pfam-B_1230 (release 5.4)	Domain	This family consists of putative outer membrane proteins from  Helicobacter pylori (campylobacter pylori). 	25.00	25.00	29.60	28.90	20.30	16.40	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.48	0.70	-5.91	9	419	2012-10-03 17:14:36	2003-04-07 12:59:11	9	1	55	0	36	429	0	455.30	38	98.14	CHANGED	hppphhhhlhhhhhsusLpAF-Y....+lsGts-SFSKlGFNpppINsp+GIYPTpoFsTlsutLpls.ssLLsKthpt..HsLcsslGGhlGulsYDSTKh..........................h.sp.........st.hhsulsa.alGhatGahssp......................s.hst..p.st............+sRsYll.NAaLcYsYKD...hFthKuGRY....puph.-ahSGasQGaEhhh.....phpph+hhWFSSaGRAhAaspWlh-aYus+s.h.pst..hN.............hGhHshslhYp.hKslplpPFhYasPthhsAPGhpIsaDoNPsFpuhGFRupTshhsha.............Plas..h....hsshp......hss.hGcsGtoLhl+QRF-aNpaNFGhuhYpsFGNANuhIGhaGNP.....................lGh-hWsNolYss...ulsshhsAsAhThasasGGsa..+pFhWplhGRhTpus........RAsEtSlulsLuYphsc.plpssl+LpYYsshh+pGYp.hGhhh.....sPh...................ssshpuhhpDRSalMoslsapF	...................................................................h.....hhhh.hhhh.t.u....LpAF-a.......clsGtspsFSKlGFNpp.....INspKGIYPTpoFsolsuhlpls.ssLLsKth.ps...HtLpsslGGhlGulsYDoTKh...................................................hhsp...........s...ht.u.hhapahGhatGahsst.............................................s.tss...p.phst............psRsYllhsAaLp.YsYKD.........hFthKuGRY....posh..sahSGasQGF-hhh..........php.ch+hhWFSSa.GRuhAhs.pWlhsa.Yushs..h...pt...t..hN.............aGhHshslhYp..pK......tlplpPFhYFuPpsatAPGhpIsaDoN.PsFp.uhGaRspTphhsha....................................Plahshh..........hsshh...............hsshhGpsGtoLhl+QRFc.a.NpapauhuhYpsaGNANu.lGhaGsP.....................hGh-hasNolYss...shsshhsAsuhThashsGGha.......++FhWtlhuRhTtus........RAsEtululsLuYphs+.plphsl+LpYYsshh+pGYp...sGhh..........sPh...................tsshtushpDRSalMoslshpF.......................................................................................................................................	0	9	26	36
+2994	PF03328	HpcH_HpaI		HpcH/HpaI aldolase/citrate lyase family	Mifsud W, Bateman A	anon	Pfam-B_3076 (release 6.5) & Pfam-B_2811 (release 14.0)	Family	This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.16	0.70	-5.46	22	6388	2012-10-10 15:06:27	2003-04-07 12:59:11	9	23	2567	40	1697	6456	3815	211.30	23	76.53	CHANGED	phhhalsusssthhchsshhGhDhlhlDlEcus...........hhltpsLpplph.tss...pslVRVssh-oshhpp......hlchGspslhlPhV-oup-stph.phhphs.tthtt.........................tsspsplhstIESupGlhNscEIA..usc........tltulhlGstDhssshGttpssstsElh.....hApsplltAu+AuGl.hhsslhsshssspsahpputhhhslGhDs+.hhps	.........................................................................................................................................................................................p.hhahsh.sss.h.hh...ph.h...t...h..h...u......h...D...hl...ll.DhE.c.us...................................................p..tl...t....p....h.l..p.......p.h...........t......h...........t....s......h.......................ps..l..VR.l.s..s..h......s...s.......h......h.....t.....p..................................hl....c...h.............G.....s....p...........s....l......h...lPt...l..co...s...pc.s...pph....st....th.p..h..................t..th..................................................................................................................................................s...tp..h.t.l...l..s.......I.E.o.s...p...G...l.......t......s.........h...s...p....IA.....us..p......................t.ls...ul...h...lG...s....s...Dh.....s..........t..........s.........h.....G......h....t.....t........s.....s.....p....t...s..-..l.....................................hAh....pp....l....h....t.A...u....+.A..s......G......l.....s..h...s..h.l..h.........s...........s.............p...s.......t...p.......t........h...h...p...t.u.t.p...h.h.t..lGhc.st.hhp.........................................................................................	1	422	997	1374
+2995	PF04982	HPP		HPP family	Bateman A	anon	Bateman A	Family	These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.	21.10	21.10	21.10	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.55	0.71	-4.27	127	972	2012-10-02 19:04:43	2003-04-07 12:59:11	8	10	814	0	435	951	937	121.40	34	44.35	CHANGED	hllAshGASAVLlFusPsSPLAQPhslluGplloAllG....ls...shphh.............ss.sh..........hus...uLAVulAIshMhhs+slHPPuGAsALlslluus.......GatallhPV.hluullLlhlAllhNs.ls..t.R.pY..Pt	..........................hllAshGASAV.LlF.u.sss.S.P..LA.QPhs..llsGplluAllG....ls...shphh....................ss..sh...........hss....ulAluhuIshMhhh+slHPPuGAsALls..l..luss..................uat.a.l.l.h.PV..hluu.llllshA.llhss.l....t...+..pYP.................................	0	128	267	361
+2996	PF01288	HPPK		7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.50	21.50	22.70	22.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.69	0.71	-4.40	115	4673	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	4045	60	1118	3316	2284	125.90	37	60.63	CHANGED	aluLGSN....l.GcptpplppAlptLpph.thplhphSslYcotPh.G....hssQs..t.FlNsVlplcT.sLsPtpL.LphlppIE.pch.GRtR.pt....+a..u......PRslDlDlLha...ssh..............h...l.....ps.......s.p............LplPHPchtcRsFVLhPLs-l	......................................................aluLGSN...........lus.....h...pplppAlp..........tL.......s.p.............h....................t...........h.p.....l.....lthSslYcTtPh...G................hp.s.Qs......s.....FlNss..l..t..l.........c.........T.......s..........L.......s....Pt.p.......L.Lp.t.....hppIE.pp.h.GR.....hR...pt.......+W...G.................PR.T.LDLDIlha.....ssp.......................h.....l.........ps....................s.c............................................LplPHs.c.hppRsFVLhPLh-l............................................	0	368	712	952
+2997	PF02603	Hpr_kinase_N	Hpr_kinase; 	HPr Serine kinase N terminus	Bashton M, Bateman A, Moxon SJ	anon	COGs	Family	This family represents the N-terminal region of Hpr Serine/threonine kinase PtsK.  This kinase is the sensor in a multicomponent phospho-relay system in control of carbon catabolic repression in bacteria [1].  This kinase in unusual in that it recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating enzymes [1]. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller. The blades are formed by two N-terminal domains each, and the compact central hub assembles the C-terminal kinase domains [2].	24.00	24.00	24.00	24.00	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.16	0.71	-4.45	84	1842	2012-10-03 03:17:47	2003-04-07 12:59:11	11	6	1787	8	328	1032	93	127.40	32	40.73	CHANGED	tp......lplpcLlcc....h..pLclls..Gccslppp.IssuDIsRPGLpLsGaFsaassc...RlQl.lGpsEhoalp.phspc.p+tphhcchhs.hcsPslIlo+sL..psPp-llcsAcctslPlLpoph.sToclhuplopaLc	........................................tlplccLl-p.......l..pL-.lls...Gc.c.s.lpct..Is..s.u..Dl..s..R..P..G..LEhsGYFsaass-...RlQl.lGpsEhoahp......p.hssc..pRh...phhcchhp..-sPslIloRuL............psPcEllcu.Acc...pslPlLpoph..sTop.LhucLosYLc............	0	115	218	275
+2998	PF01627	Hpt		Hpt domain	Bateman A	anon	Pfam-B_971 (release 4.1)	Family	The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined [1]. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to  contain a binding surface for Ssk1p (response regulator receiver domain containing protein Pfam:PF00072) [2].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.91	0.72	-3.98	241	11727	2009-01-15 18:05:59	2003-04-07 12:59:11	18	665	2711	46	3296	9899	750	93.10	19	13.09	CHANGED	pllphFhpc.stchlpplppsl...p...............ttshpplhctsHpLKGuuuhhG.hpplsphspplEphhcptp..ptp.............h.thhptlpphlpplpst	............................................................................hlphFhpp..st.ch....l.ppl.pp.tl....p...........................tpshp..s.lhctsHplKGu.uu.hl.......G.hp.p.ltpls....ppl.E..p.h.h...pptp...psp..............................t.l.pthstlpp.lt.....t.....................................................................	0	1088	2075	2778
+2999	PF01628	HrcA		HrcA protein C terminal domain	Bateman A	anon	Pfam-B_1133 (release 4.1)	Family	HrcA is found to negatively regulate the transcription of heat shock genes [1,2]. HrcA contains an amino terminal helix-turn-helix domain, however this corresponds to the carboxy terminal domain.	19.90	19.90	20.00	19.90	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.04	0.70	-4.77	165	2791	2009-09-11 06:48:32	2003-04-07 12:59:11	16	9	2743	3	636	1950	812	218.70	24	63.95	CHANGED	l-cllppuuclLSpLTphsullhsPp.hppspl+plclVsls.sp.plLsllVscsGpVcspllpls.....................p..sl.sssc....LpphsshlNspLt......Ghslsclppplhp.t.lttthpp..htphhcphlpthtps.h..ttt.......tp..pclhlsGpsNllpts..Ea.ps..........hpcl+pllphl...Epppt..lhpLl..........tps.p.psp...s.....................lplpIGsEs..........hpshpssSllousYphs..s.....p...........................sl.GslullGPTRMsYs.+sl	..........................h-cllppuuplLSplTphsu.l.lhsPp...p.psplcplcll.Ls..sp...pslslllsssGpVcsphlpls....................p.sh..sppp....Lpch.sshlNp+lt......Ghs..l..t..-lpp.pltp...p....l...........s.p.h.h.pp..................ht..p..hhps.llshh...tph.h.t......p.........pplhluGpsNLlphs...ph..ps..........hp.plpplhphl...Ep.ppt..lhpLl...........pph..t...psp.......s............................lpltIGsEs........t...tsl..p..shS.llousYths...t...p.........................................................................hh.GslullGP.T.R.MsYsphl.......................................................................	0	229	443	550
+3000	PF04877	Hairpins	HrpZ;	HrpZ	Kerrison ND	anon	Pfam-B_6141 (release 7.6)	Family	HrpZ from the plant pathogen Pseudomonas syringae binds to lipid bilayers and forms a cation-conducting pore in vivo.  This pore-forming activity may allow nutrient release or delivery of virulence factors during bacterial colonisation of host plants [1]. The family of hairpinN proteins, Harpin, has been merged into this family. HrpN is a virulence determinant which elicits lesion formation in Arabidopsis and tobacco and triggers systemic resistance in Arabidopsis [2].	20.50	20.50	31.60	20.50	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.01	0.70	-5.01	11	233	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	84	0	19	217	1	221.70	27	93.65	CHANGED	MQh.............L...uhssu.LtoshtshsLstsps.s.u.uoSocpLppVIsQLAptLT...................tsGphssoSPLG.....................................KhLsKuhusD........................................................GctGGhhcsVpsALcpLIpEKLGDNFGAuus..............ss.GhtGh.tsuuuuuQpDLhspVLsGLuK....usLsDLLT.ppusGToF.ScDDMPMLccIAQFMDDsPupFspP............DuGSWupEL.K.EDNhLsGsETAQFRuALDlIGptLupptsttssh.....sGGLG.................................G....DsGp.h.....hGhpu..uGtGhGoss.s..p............phspLltGL..pGLtusLpssGtsGssLpsSAApsushllshhL...pNpusA	.............................................................................................................................................................................................................................................................................................s..ss..psl.ssLptlhtptLup..ut.s....................................susss..pLhstl..h.ulup....p.Lssl.s.p.....p....sss.ppF.s.....ppDhshhpclupFMDp.Pt.FspP............DstS.....WhptL.c.-Dsh.....hs.tphttFppAh.shItpthu......................................................................................................................................................................................st......................................	0	0	5	11
+3001	PF02218	HS1_rep		Repeat in HS1/Cortactin	Bateman A	anon	Pfam-B_5631 (Release 5.2)	Repeat	The function of this repeat is unknown. Seven copies are found in cortactin Swiss:Q14247 and four copies are found in HS1 Swiss:P14317. The repeats are always found amino terminal to an SH3 domain Pfam:PF00018.	21.00	21.00	21.50	22.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.57	0.72	-4.07	18	1059	2009-01-15 18:05:59	2003-04-07 12:59:11	10	23	81	0	511	857	0	34.90	59	36.89	CHANGED	GFGGKFGVQpDRhDKSAVGaDYpuKl-KHsSQ+DYu+	.........GFGGKaGVQpDRhDKS...Al.Ga-YptchpKHpS.Qp...Dhs.................	0	125	164	293
+3002	PF00447	HSF_DNA-bind		HSF-type DNA-binding	Finn RD	anon	Prosite	Family	\N	21.00	21.00	21.00	21.00	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.76	0.72	-3.86	114	1989	2012-10-04 14:01:12	2003-04-07 12:59:11	12	26	337	17	1305	1973	19	99.60	36	21.34	CHANGED	sFlpKlaphl-..........Ds............shsplIpWs..ps.G...soFllhs.spcFupplL..Pp...aFKHsNauSF........VRQLNhYGF+Klpsspt......................................................aEFpppt..F.p+Gpc.........cLLpp..I+R+pssp	........................................................FlpKh..a..p.hlp............................-s.....................p.h...s..pll.pWs...ps..G.............soFl...V.hc........p.pF.sc..........p...l.L.........P.c.............a.F......K............H......s....N....auSF...................lR.......QLNh....Y....G.F+Klstsptt.........................................................hEFtp.t...F.h+G.p...........pLLpp..I+R+t..s........................................................................................................	1	519	792	1058
+3003	PF00011	HSP20		Hsp20/alpha crystallin family	Sonnhammer ELL	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.33	0.72	-4.16	37	9881	2012-10-02 21:54:05	2003-04-07 12:59:11	16	34	4016	178	3585	8031	3065	97.10	23	59.55	CHANGED	-h+cscstathphDlsGhp.t-.-lcVplc-sp..lllpupcc......Eccsschhh.tht.tpFhR+apLP-..ss-h-plpush.psGVLslolPKhtst.......ps+sIplp	..........................................................................................pscspat.l.p.h-l..s...G..h...p..p...........-..-.lc..l..p...l.....p..s......s..h........Ls....l..p...up+p..............................................tp.p...p..p......p...p...h..h..h..p...t...h..............t..p..F.p.....Rp..a.p.L.....s.t.................s.....s.....-..t...p..p..l.p.Ash...ps...G..l.Lplsl..s+ttsp........psppItl............................................	0	1108	2207	2972
+3004	PF01430	HSP33		Hsp33 protein	Bateman A	anon	[1]	Family	Hsp33 is a molecular chaperone, distinguished from all other known chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localised protein with highly reactive cysteines that respond quickly to changes in the redox environment. Oxidising conditions like H2O2 cause disulfide bonds to form in Hsp33, a process that leads to the activation of its chaperone function [1].	21.40	21.40	22.00	21.90	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.46	0.70	-5.28	181	3184	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	3110	8	630	2039	673	275.00	33	92.77	CHANGED	pDtlh+.hhhpsts.....lRuhhlphs.pshpcshpp.Hs.......hsssssthLGcslsussLlu.usLK..hc.splolplps...sGPlshlls-s......sssuplRGhs.......t.spsph.s............sltthl...Gp..GhLsl.oh.D......uh....tp.YpGhVsL...tus......plu-slptYatpSEQlPotlhLush....t.........httAuGhllQhLPss.............................cc.-shsclpphhp.....shhsptLl..shsscpl.Lp+La..p-t........lclh-s....pslpFpCsCS..+ERhts.sLtslupcElpchlpEp.Gpl-lsCcFCsppYpF..st	....................................................................................................................Dhlh+hlhpsts.....lRuhhlpso.colppshp.p.Hs..............hs..sss..pssLGchLsAssLLu.As.LK...hc.sclTlp.lpG..........sGPlshllssu.........s.sptplRGhs........splsh...s.t.................sltshl......Gs...Ghl.sl....sh..D..........u........t-.YpGhVsL..us.........plu-slphYatpSEQlPoplhLssh......pps.........................htsAGGhllQlhPus.............................pc-shs+lpphhp........shho.p..Ll.......shs..s-pl.LhcLat..--p....................lpl.h-t.......................pslpFp..CsCS....+E....Rhts.ALh.oL.scc...Elpshl...pE.....-.tt..h-hpCcFCsscYpFs.....................................................................................................................................................................	0	197	392	522
+3005	PF00012	HSP70		Hsp70 protein	Bateman A, Sonnhammer ELL	anon	Prosite	Family	Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release.  Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	602	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.87	0.70	-6.61	33	23002	2012-10-02 23:34:14	2003-04-07 12:59:11	15	120	7604	156	6301	21235	9750	370.00	30	85.27	CHANGED	llGIDLGTTNSCVAVh-uGcsclIsNsEGsRTTPSlVAFscs.ERLVGpsAKpQAlsNPcNTlausKRlIGRcas-..lpp-hp.hPa+lsps.sscshlpsp...Gc..paoPpcISAhlLpKhK-s.AEuYLGcs..VscAVITVPAYFNDuQRQATKDAGpIAGLpVLRIINEPTAAALAYGLDKps.......-cpIlVaDLGGGTFDVSlL-ls..cG..VFEVhuTsGDTHLGG-DFDp+llcallpEFK+c.pGl.DLppDphALQRL+-AAEKAKh-LSS.tpTplsLPalohsstG..shclshsloRA+FEcLssDLlcRThpPscpAL+DAtls.ts-ID-VlLVGGSTRlPtVQchVcchFG.K-PsKuVNPDEAVAhGAAlQuGVLoG......-V+DlLLLDVoPLSLGIEThGGV.hT+LIpRNTTIPTKKS.QlFSTAsDNQs.uVpIpVaQGERphspDN....+hLGpFcLsGIPPAPRG.lPQIEV..TFDIDANGIlsVoAcDK.uTGKcppIoIpssuG.Loc-EI-+..................................MVc-AEpaApcDcpp+EplEs+NpuEshsass-pplc-h.....t-KlssscK....pplcsslptLcpsh....ttt-......h-chcschccLpphs.tlspphYp	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.l........s....h..l....h......t.t............s......p...t.................h............t......t...................l.........t...............t.........s..........V.........l.........sh.P.......s.............a........s.......s........t.......p.......+.....p....t........h......h.......p.........A.......u.......t.....h.......u..........G.........h............p......s....................p.........l........l........p...E.....P....s.........A..A............u...h...........s.....a......t....hp...p.t................................t.t...l...h..l..hDh.................G..G...G...Th.D.....h...o.....l...l...........p.....h...............t...............t.......s........................h.......p.........l....h......s.......s.....s.........t...s......t.....................l..G.......G.............p..........s.h....D..................h...h.....h.p..............h.h....h......t........t...........h............................................................................................................t..............................................p...........................................t......p..........l....h......p.............t..s......c.....t...s...K..............h..................t...........L.....S....s..............................t........................t......h.....................h..................................h.............................................................................................................................h.......................t.................l...s..............c..............t..........p................h............p.....t...h.......................................h.....................h...............t.....t..............................h.............h.......p............s.......l......t.....p..........u............t...h.....p...............t..............t.........l..................t.......t...l....hh.s.GG...s.phPh....l....p..l..t.......t........h.................t.......................................................t.......................p....s.............t....s...h..s...G...s..s........h...............s.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	2234	3809	5213
+3006	PF00183	HSP90		Hsp90 protein	Finn RD	anon	Prosite	Family	\N	24.40	24.40	24.50	24.50	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	531	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.95	0.70	-6.11	11	5703	2009-01-15 18:05:59	2003-04-07 12:59:11	13	30	3641	350	1566	4977	1328	358.50	32	66.61	CHANGED	EYLEEc+lKElVKKHSEFIuYPIpLhVpKEhEKEVs--Et-ppc-Etc-c-..............t.chEEs--EcEc-pKK.KTKKVKEsspEhE.LNKpKPIWpRsPc-lTpEEYuuFYKSLoNDWED...LAVKHFSVEGQLEF+AlLFVP+RAPFDLFEsp..KKKNNIKLYVRRVFIhD-s--LIPEaLuFlKGVVDSEDLPLNlSREhLQQNKILKVIRKNLVKKsLEhFpElA......................EcKEsacKFYcpFSKNlKLGIHEDusNRs+LAcLLRapSo+SsD-hsSLcDYVoRMK-pQKsIYYITGESKcpVEsSPFLEpL+cKsaEVlahTDPlDEYshQQLKEFEGKKLsslTKEGLcL-EsE-EKcpcEchKccaEsLsKhhKc.lLsDKVEKVVVSsRLssSPCslVTSpaGWSANMERIMKAQALR...DoShsuYMuuKKshEINP+HPIIcEL+c+.scsDpsDKoVKDLshLLaETALLoSGFsL--PpsaAsRIaRhl+LGLsIDED-ps..p-..spsthpstssscpssssScMEEVD	...........................................................................................................................................................................................................................................................................................................................p.......c......p.............lNptpsl......Wt.Rs.p-..lopE..-Y.tpFY.................+p.l.s.p..-..a.....p-........L.h.hh.H..p..sE...G..p..hcapulLalPp.p.s.P.a..D..h...a.p...p............t..p..p.s....lK.L...Y..V......p.....RV.FIhDs.s..c.p.hhPpa.LpFl+.GllDSpDLPLNlSREhL.Q.......p......s......p......hl.c......hl+ps....ls.K..+s.l.p.hh...p...c.l..s..............................................................................c..c.t..-.p.....Y.p..pFa.ppFuh...........slK...G..h...h...p....D........t.....s.....+...p.....p.ltc.LLp..at.......o.................o.................p.................p..............t.......t..........p..................h..............s..........o........Lp..-.......Y..l...................p..R.....................M...........p..........................-............s..Q.....p......p............IY..Y.l.s..........u..p.sh......tt...............h.ppSPalEhh+p+..G..hE..Vlhhs-...l.D.Eahh.p...l...p..-.a.........-...........s....K.......t.....h...s......l.......s........c........t....t.......h....p......l.......t......p........t.......-........c.......p.....p......p........t...................c.......p......................p..........t...........t............h...........p..........s.l.h....p.h.h...Kp....h...L..t..c...c.........V.p...c....V........h..l........o...p.R..L.........s..s.....o...P..shl.s.s..s..t....t..h.sh.p.Mt+.hht..t...............................................h................p.....hhElNsp...Hsl..l.p.t...........h...............................................................t.......t..........t............h...........t...p......h....s..l....lhp.u.hl...p.t.............t..p.s..t.....a.tth.p.h................................................................................................................................................................................................................................................................................................................................	0	594	973	1277
+3007	PF04119	HSP9_HSP12		Heat shock protein 9/12	Wood V, Finn RD	anon	Pfam-B_14318 (release 7.3);	Family	These heat shock proteins (Hsp9 and Hsp12) are strongly expressed, an increase of 100 fold, upon entry into stationary phase in yeast [1,2].	26.30	26.30	26.30	26.70	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.95	0.72	-3.89	24	130	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	97	2	87	129	0	58.00	47	59.56	CHANGED	MSDsGRKsh..............o-KspEtlTPDSpKSThEKsKEsVTstsD+hAussps-spKShsQpssDp	....MSDsGRKsF..............osKApEplpPDSpKSshE+sKEplTDssD+lAushQP-spKSssQpstDp.......	0	23	49	74
+3008	PF04213	HtaA	Htaa; 	Htaa	Yeats C	anon	Yeats C	Family	This domain is found in HtaA, a secreted protein implicated in iron acquisition and transport [1].	21.80	21.80	21.80	21.80	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.04	0.71	-4.01	25	599	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	181	0	91	421	21	153.20	31	45.43	CHANGED	sslssGshs..WGlKpSFpsYlpGs.lApGsaphss...Gus...tssspFsF.shssushD...ssspssslpasGsV+as..GHp.............hhLDlslussclshsGssGpLhs-lsSpphp.sstsshut......lslAslshsuhsh...ssssshss.ssstLTtpGupsFusaYsAGpsLDPlohshsh	...................................t..ltpGohsWGl+pSFpsYlpus......s.....pG.p..hphsu................Gus........hssstFsF..shs...su.sh..D....ssps.sslpasG.s.V+as.Ghp....................shLDlolu-Ppls.lp..s.u..s..uplhhs.lp..Sps.hs...u.p.hshuc..................lshushssusht........ssssshsu.ssspLTupGscs.F..u....G.....FY..psG.p..s..h..Dslohslt.h.............................................	0	28	66	91
+3009	PF00126	HTH_1		Bacterial regulatory helix-turn-helix protein, lysR family	Sonnhammer ELL	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.67	0.72	-4.23	1536	86700	2012-10-04 14:01:12	2003-04-07 12:59:11	22	49	4604	63	20714	62728	5685	59.70	33	19.98	CHANGED	lppLchFhslscps.ShopAAc.pLsl...opsulSpplppLEp.pLGsp....Lhp..R....tt...p...t..l.pLTttGp	........................ppLchFhs.l.sc.pt....ohopA...A..c...pL..tl..........op.s...ulSpplpp.L....Ep....pL....G.s..p........Lhp......R...............ss...+....p......l.pLTptGp........................	0	3926	9597	15357
+3010	PF04967	HTH_10		HTH DNA binding domain	Bateman A	anon	COG3413	Domain	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.14	0.72	-4.38	30	808	2012-10-04 14:01:12	2003-04-07 12:59:11	7	73	81	0	433	919	135	52.70	37	16.19	CHANGED	LT-+phplLptAachGYF-hPRcsslp-LAcplGIScsohpp+LR+AppKlhp	................LTc+QpcsLptAhctGYa-hP.Rc.sohp-lAcpLslSpsohsp+LR+App+ll.t.......	0	47	296	420
+3011	PF01022	HTH_5	HTH_ArsR_family;	Bacterial regulatory protein, arsR family	Bateman A	anon	Pfam-B_139 (release 3.0)	Domain	Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-7.91	0.72	-4.29	42	9132	2012-10-04 14:01:12	2003-04-07 12:59:11	15	65	3608	33	2609	16970	1782	47.00	32	34.44	CHANGED	cssRlcIlhhLtc...sp.hsls-lsptlphopuslScHLchLcctGlVpp	..........................................c.sRlp.I.l.t.hLtp.........s-...h...s....V.......s.......-.....L.....s......p......t......l......s......h......o.....p.....s..s.l.SpH.Lph.L.+psuLlp...............	0	903	1744	2237
+3012	PF01418	HTH_6		Helix-turn-helix domain, rpiR family	Bateman A	anon	Pfam-B_3373 (release 2.1)	Domain	This domain contains a helix-turn-helix motif [1]. The best characterised member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.14	0.72	-4.25	10	9722	2012-10-04 14:01:12	2003-04-07 12:59:11	12	9	2886	5	1519	5638	383	75.30	25	26.84	CHANGED	hslLppIpsthpcLscoE+KlA-aILssscpshphSlsplAptuuVS-uollRFs+pLGapGFs-hKlpLup-lusp	................................h..plpp..t..h.p.pL..o..ps.E..cc.....lA.c....a.ll.p.ss.p.p...s....h.pho..lp...cLApps.s....l.S..puolsR.Fs+.+.l..Gap.Gap-....h.K..htLtpth...t.....................	1	359	791	1163
+3013	PF02796	HTH_7		Helix-turn-helix domain of resolvase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.01	0.72	-4.10	14	3816	2012-10-04 14:01:12	2003-04-07 12:59:11	10	39	1793	24	542	3351	302	44.90	28	23.91	CHANGED	GR.pphscp..p......hsplhpLhppG.hshpplActhsloRsTlYRhhsst	...........................GR......p..hspp.....p...........hpp.lh...c.h..h....p....s...G...h.....s..hp..plAcphsl.oR..s.TlYRhhtt.t........	0	153	335	445
+3015	PF00165	HTH_AraC	HTH_2; 	Bacterial regulatory helix-turn-helix proteins, AraC family	Sonnhammer ELL, Griffiths-Jones SR, Studholme DJ, Schleif R	anon	Prosite	Domain	In the absence of arabinose, the N-terminal arm of AraC  binds to the DNA binding domain (Pfam:PF00165) and helps to hold the two DNA binding domains in a relative  orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerisation domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilised when AraC activates transcription, and  hence AraC ceases looping the DNA when arabinose is added [1-2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.91	0.72	-4.00	75	482	2012-10-04 14:01:12	2003-04-07 12:59:11	18	29	353	4	136	54828	2557	37.30	26	22.38	CHANGED	lp...psp.hsltclApphuh.Stshhp+hF+pthGhoPppahp	...............................plpplAppsGh..S..t.pa.F....p+hF.Kchh.GhoPtpah..................	0	48	84	114
+3016	PF04204	HTS		Homoserine O-succinyltransferase 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.84	0.70	-5.69	77	2128	2012-10-03 00:28:14	2003-04-07 12:59:11	11	3	2054	3	324	1318	572	290.40	50	95.62	CHANGED	PI+IPcsLPAhclLppENIFVMs-sRAtpQDIRPL+IhILNLMPpK..lpTEsQlLRLLuNT..PLQl-lsLl+hsoHpuKNTst-HLppFYcsF--l..+sc+FDGhIITGAPlEplsFE-VsYWcELpcIh-WocspVpSTLalCWGAQAuLYaaYGlsKh.LspKhaGVFpHp..shp.ps.LhRGFDDpFhsPHSRaT-lpcc-l...pptssLplLucS--sGshlltscct.RplFl..hGHsEYDspTLppEYpRDhtpGh.s.....hplPtNY...........................aPsDDPsppPhspWRSHApLLFuNWLNYhVYQpTPY	.....................................................PI+lsccLPAhphLcpENlFV.MsppR.Atp....Q....-IRPL+llILNLMPpK..lpTEsQhLRL..LuNo....PLQV-lphL+hco+pS+NTssEHLpsFYpsF.....--l..ccppFD.....G.hIlTGA.PlEtlp.FE...-VsYWp.Elpplh-WuKsH..Vp..S..TLalCWuAQAuLhhhYG.l...sKhshscKl.GVYp...H..c...h..l..c..s...p...s...h..L......h......RGF.D....D......s..Fhu.P...HSR.as-hst.ppI...pp.hs-.L.cILuco-.-.u.GshLhso+Dt..RplFl..hGHsEYDspTLspE....YhRDlptGl..s......sc..l..PhNY............................FspsDP...pp.pP.pssWRSHusLLFsNWLNYhVYQ.TPY...................................................	0	87	185	247
+3018	PF04955	HupE_UreJ		HupE / UreJ protein	Bateman A, Eberhardt R	anon	COG2370	Family	This family of proteins are hydrogenase / urease accessory proteins.  The alignment contains many conserved histidines that are likely to be involved in nickel binding. The members usually have five membrane-spanning regions.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.75	0.71	-11.52	0.71	-4.98	80	494	2012-10-02 18:22:22	2003-04-07 12:59:11	7	4	398	0	191	653	600	177.30	34	89.46	CHANGED	lsh..h...hhsssAhAHsupst...su...GhhuGhsHPlhGhDHLLAMlAVGlWu.uhhus.....+uh.........ahl....PhuFlusMll.GusLulsGls.lPhVEssIusSVlllG..LllA......hst+lPh....ssuhullulFAlFHGaAHGsElsususshh......YshGFslATuhLHhsGlulGhhltpttt........lhRhsGuslAssG.hhL	...................................h..lhhhsssAhAHsuts.........ts.......Ghhu....GhhH..Pl.hGhDHLLA..MlAVGlhu..uthtt.....ptt................hhl....Ph..s..F....l...s...s...M..ll...G...u...h...l...G...h...t...G...l...s...l.....P.....h...sEssI.u.sSl.l.llG....l.h.lu...................hs..h....c..h.sh.................hh.u...h....sls.....ul.FA..lFHGaAHG...s...E....h.....ss....susshh............YssGFshuou.h.L.as.s.Ghu.l.uhhl..tphts.................hhRhsGu.shAhhGhh.................................................................	1	43	101	146
+3019	PF01455	HupF_HypC		HupF/HypC family	Bateman A	anon	Prodom_3112 (release 99.1)	Family	\N	19.60	19.60	20.50	19.90	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.26	0.72	-3.98	170	2243	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	1433	6	492	1128	72	69.50	44	76.37	CHANGED	MCLulPucll....pl........p..sphAh...l........-hs.G..lp+clslsLls.-......splGDa.VLlHlG..aAl.pclDccEApco.Lphhp	............................MClGlPupll....sl.........-..tphAp.....V........-.ls..G....lpR..-VslsLlsp.......stlGpW.VLVHVG..FAh.uhIDEpEAccTLcsL...........	1	163	329	421
+3020	PF04809	HupH_C		HupH hydrogenase expression protein, C-terminal conserved region	Mifsud W	anon	Pfam-B_3701 (release 7.6)	Family	This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown [1].	21.20	21.20	29.80	21.30	20.00	21.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.44	0.71	-4.35	36	1273	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	541	2	95	481	8	110.40	37	72.84	CHANGED	GlhNAPslLsEIt-+sts...htsustsHVINLTLLPhostDhsaLsphLGpGslsl.LSRGYGsCRlsuTuhhpVWpVpaaNShDslIL-TlElsslPcVAhAAsEDlpDStcRLpEllc.slp	...........................................hsLhpELhtplpp...........ss...scslsls.LPlstsD...RtFLspLLGcGpls..l...pp........t..s..hu....ESc...IppThhsGlW+VRphss.h..cp.hLhD.plEluslP.p.sh........A.u.tD.................h...................	0	30	56	72
+3022	PF01750	HycI		Hydrogenase maturation protease	Bashton M, Bateman A	anon	Pfam-B_548 (release 4.2)	Domain	The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal [1].	20.60	20.60	20.80	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.51	0.71	-4.60	27	2632	2012-10-01 20:58:29	2003-04-07 12:59:11	13	8	1344	10	545	1351	63	127.40	28	73.29	CHANGED	l+llEtLpctht..t......pVpllDuGTtuh.Ll.hlpp....hc+llllDAlch.GhcPGplchlcs--lsp..hthc.hShHphshtpsLphhp.htph.tclllhthpshph--...hshsLoptVcpslspAlchllpt	........................................chsctL..ttpht.st..........tlcllDGGTtu.h.p.L.l.s.hlpp......sc+LlIlDAl....ch..G...h..sP.Gsl.......hh.......h.c.......s....-..........c..l.....ss.....hh.s....t......t......h.......S.....s...HphshsclLs..hh..c..h..p.....G..p.h..P.tcl..hl.lGlp..P.p............l..c............thsL.....ot.lcst.ltsshpth...t...........................	0	173	357	462
+3023	PF01968	Hydantoinase_A	Hydantoinase; 	Hydantoinase/oxoprolinase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.70	0.70	-5.31	61	2437	2012-10-02 23:34:14	2003-04-07 12:59:11	13	36	1379	6	1233	2598	1387	281.50	29	34.74	CHANGED	RssTsllNAhLtPlhppalptlpstlcptsht........................................splhhhpusGGlhshcpupppPlcslhSGPAuGllGAuh.....hsGhc........shIshDhGGToTDluhltpGpschsppstl............uGhhsph.hlclpolusGGGSll.hhtpstth+.lGPpSuGspPus...............................................................hshshGGp.hTlTDAslhLGcls.p.hh.....tt......phs.thh.t.hut.h............................................pplApthlplsstphscul+hl.................................................................................s.ppshsspshslsshGGuu.shasstlA..ctluhppllh..hs.uVhsAlGhhlAclptch	.............................................................................................................................................................RssTsllsAhltPhhppa...lpph....p...p...t...lp...p....t..t.h.t..............................................sp.lh..hhp.us.GG.lhshpp....hp.t.h..cslhS.GPA....u..Gl.h.Gushh...............thsu...h.p.........................................ss.lshDhGG.......ToTDl.u.h..l....s.......tG......p............c....h.s...ps.th..............uGhthp..hsh.lcl.polusGGGSll........h.......p...........s......u.....t........hp..VGPcSAGupPGP..................................................................................................................ssat.....t...G.G.............h.Tl..T..D.As......l...h.L..G.t.ltsp....hs.........ttt.....ls.ths.t..t....th....tt.lut...lsht........................................spps..At.uhlcluspphspsl+tl...............................................................................................................s.t.pG..hcs.p...p..hs.Lh.sh.G.GuG.....s.ass.tlA......ctlG.....hp.....p.l.....ll..hs....ul.huAhGhulAclt...h......................................................................................................................................................	0	388	797	1050
+3024	PF02538	Hydantoinase_B		Hydantoinase B/oxoprolinase	Mian N, Bateman A	anon	COGs	Family	This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase (Swiss:P97608) EC:3.5.2.9 which catalyses the formation of L-glutamate from  5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to Pfam:PF01968.	21.40	21.40	21.90	22.50	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	527	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.60	0.70	-6.28	6	1619	2009-01-15 18:05:59	2003-04-07 12:59:11	9	25	1011	0	830	1658	1539	505.30	33	58.32	CHANGED	hDPIhLE.lFpshatsIAEpMGhhLcpTAhSsNIKERLDFSCAlFDusGsLVAsAsHIPVHLGSMupuVKthl+.thcs..plcsGDVhlsNDPYhGGTHLPDITllsPlFpsst..llFaVAuRuHHADlGGlTPGSMPssSpplapEGhlIss.phLscsGchp-phhc.plhlcss..a.....sRsPcsslu.DL+AQIAANpcGIcpltchI-caGhcsVttahs+lps.uEcul++tIsclss..Gphca.......chDsstpIslplplchcptphhlDFoGTSsQscsshNAspulssuulhYsh+sLlssDIPlNcGCh+PLpIllPcGollsP..cpPAuVsuGNVETS......QtIsDslauAhs......V.AsSpGoMNNlTaGsts............asYYETIuGGoGAu......sGhsGssAVaopMTNohhTDhEllEpcYPlLlpEaulRpsSGGtGKaRGGsG..lVRphcFhpshololLusRR+luPaGltGGpsGusGcN.hlh+ssGsclclsupsolalp....PGDR..............................llIcTPGGGGYG....hp....hcD	....................................DPlhLp.lhp.pthhuIAEpM.uhsLp+TuhSssI+EchDaSsAla...s.s......c.G...p...l..l.A.p.A..s.p.l..PlHl.G.........o.M...s...t...sl.c..t.hlc...th.t.s..........slc.sGDVhlsNcPa..t...G...G.....o....HLPDlolls..PlF.............t.........p.........s....p..............l...............l...........h....alA.u+uHauD.................lGGh..sPG.Shs.spuppla.pEGlh.lss.h+Ls...c....pG...p.h..p..-p.hlp.......hl....hpss...........................R....sspp.shu.DLpAQ.lAA..s..pp....Gh..ppltcllpcaGh-.sV.psh......hptl............pcpuEpssR.ph.l....p..p..l....s....c...............G.p....h....p.h...s.....................s.th.D..s..s.....s.....lp..l...pl..s..l......s.......h......p.....s.............s....p...........hhhDFsGT...us.p.s...s..shN.....u....s......h......u......s.....s..h......u....u.....l...h......a.....s.....h..+......sll.....s........s......-......lP..h.....N.p.............G.sh.pPl.plhl.P..c..Gol.....L...s.P........phPA...A..V..su...u.....s....s...s..S........p...t..ls..cslh.tAhs....................................s..A.u..u...p.....G..s...h.......N....s.....h...s...h.G..stp.............................a..t.h....a...E..o.....l...u...G.G...s....GAs..............sshcGt..s...u...l...p..s...p..h..o.....N.o...p...h..T.s.sElhEt.caP.ll..l.cp.ap.lR.t.s..S.G.GsGcaRGGs..G....sh.R....p..l....c..h..h....p..s....h....p..h..s.l..l..u....p..R...p..h..h..s.....P..a..GltG.....Gts....G.......t.......h.......Gts....h.....l..h.....c.......t..............s..................s..........p.............h.......................p....l..........s...u..p...s..s...h...t..l.p........................s.GDh..............................................l.hl.T.P.GGGGaG.....t.........t..................................................................................	0	241	519	705
+3025	PF01185	Hydrophobin		Fungal hydrophobin	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	21.50	21.40	21.20	21.30	hmmbuild  --amino -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-11.33	0.72	-3.53	69	519	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	203	0	178	496	0	81.40	33	62.51	CHANGED	C.ss..uslpCCNpspsuss.........hhsslLu.LLGhsht........shsuhlGh.sCoPlsl...l.ul.uss.......u.Cssps..VCCpss...shs.GLls.lG...Cs...Pls	.......................................C..ssuplpCCNpsppuss........s.......hsshLs.L.l.G.h...hs........shpu.h.lGh..pCoslsl......l.sh.uhs....................spC...ppp...sCCpss.....s.s...G.Lls.lG....C.sl.............................	0	98	127	156
+3026	PF01155	HypA		Hydrogenase expression/synthesis hypA family	Finn RD, Bateman A, Yeats C	anon	Prosite	Family	Four conserved cysteines lie either side of the least conserved region.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.63	0.71	-4.39	169	2158	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	1453	7	454	1106	89	112.50	38	96.54	CHANGED	MHEhSlspullchlpc.pApppt.....sp.+VppVpLclGpLosVps-sLcFsF-shscsT.................................lscsAcLpIpphsspshChsCupphplpphh...................................CPpCGuhpl.pl.hsGcEhplcplEl-	.........................MHEloLspshlEllppp.Appp.s.......sp..+VssVaLcIGshSsVEssulpFsF-.ls....s.c..G.T.................................lAc.Gs.cLclp.tsApsaChsCsphspltppp....tp................................CPpCpu.p.p.l.pl.ssG.-pLpl+pIEl........................	0	154	306	388
+3028	PF01924	HypD		Hydrogenase formation hypA family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas [1].	25.00	25.00	27.80	27.80	22.60	22.30	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.09	0.70	-5.71	129	1488	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1407	2	399	1039	96	349.00	49	96.11	CHANGED	Dsph..spt.LhcpI.pphsp........c.shplMEVCGGHTHoIh+aGlcpLLP....pslchlHGPGCPVCVhPhtcIDpAlpLA.....tpssVIlsTaGDMhRVPGSpt...............................S.LhpA+A....cGA.DVRhVYSPhDAlclAccNP-+pVVFFAlGFETTsPsoAhslhpAt...........ttslcNFslhssHlllPPAlcslLp..ss.......p.splcGFluPGHVSslhGscsYc.lsccaphPlVVuGFEPlDlLpulhhllcQlppG.....cscl-N.pYsRsVpt-GNhtApphlscVF-lp-p.cWRGlGhIPpSGLpL+ccaupaDAcp+Fs.....ls.....thpss-spu...CpCGclL+Ght+Pp-CtlFGpsCTPpsPlGuCMVSoEGACAAYYpYs..ph	......................p....shpLhcclccpss...s.....+PlpIMEVCGGHTHuI.hKaGLcpLLP....c.s.l-hIHGPGCPVCVhPhuRIDsslclA.....pps-VIhsTFGDhhRVP.Gppu..............................................SLlpA+A......cGA.DVRlVYSPhDALclApcNPs+...cVVFFulGFETThPsTAlsLppAc...........tcslpNFhhaspHlpl.PslculLc....ps..........s..stIDuFLuPGHVShllGscsYphlAp.............ca....pp...........PlVVuGFEPLDlLpullMLlcQhhtu......cscVEN.QYpRlVscpGNhhAQphls-VFpl.sss.EWRGLGhItsSGlcLps-YppFDAEt+Fc......ss...............sp.p.ss-.s.tCcCG-VLpGhsKPppCsLFGpsCsPpsPhGuhMVSSEG.ACAAaYpYppt....................................	0	137	272	345
+3029	PF02494	HYR		HYR domain	Bateman A	anon	[1]	Domain	This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat.  This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.74	0.72	-3.97	19	1816	2012-10-03 16:25:20	2003-04-07 12:59:11	11	329	171	0	1519	1518	549	80.40	30	16.53	CHANGED	VDTsPPsV.sCsss.lhpsVElGsssspVhasEPTAsDsuG..pssLloRospPGD.FPVG.posVTYsapDsuGNpA.sCsFTlsV	.........................................DspsPsl..sC.....P......ss...hphs..s......s........u.....p...s...s.....s.....s....V....s...a...s...t...P.....s....A...o.DNss..............s.s.s..l...s....s.........s....t..s....s.........G...s...........h..Fs.....l....G....s......s.....s...V..s..You.s.D.s.uG.Nsu..sCs..FpVsV..................	0	1239	1292	1437
+3031	PF01608	I_LWEQ		I/LWEQ domain	McCann R, Bateman A	anon	[1]	Family	I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin Swiss:P26039 and yeast Sla2p Swiss:P33338 interact with F-actin [1]. I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB Swiss:P54633 and SLA110; (3) metazoan Hip1p Swiss:O00291; and (4) yeast Sla2p Swiss:P33338. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [1].	36.30	36.30	36.70	36.30	35.80	36.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.93	0.71	-4.27	22	586	2009-01-15 18:05:59	2003-04-07 12:59:11	12	37	239	11	325	542	0	147.60	43	10.97	CHANGED	FY+KNsRWTEGLISAAKAVAtATshLlcsAssllp....ups....o.E.pLIVASpEVAASTAQLVAASRVKAshsSpspppLppAS+sVopAscsLVppspshhpptcp.....pcslDhspLo.tphKstEMEQQVcIL+LEppLptAR++LuplRKpp.Ypps	............................Ytcsu..pWoEGLISAAKuVAtusssLl...EuAss.llp....Gcu..............s.E.cLIsuu+pVAASTAQLVsAo+....VKA..sh.sS.c..s.h...c+Lp...............t............A...........u+uVs.........pAscsLVp.uspsutpp..ppc.................p-s..hc..hs.p...hshhph+spEM-sQs.......c....lLclEppLpptRp+LuplR+p.p.Yp..h............................	0	97	141	228
+3032	PF04568	IATP		Mitochondrial ATPase inhibitor, IATP	Kerrison ND	anon	DOMO:DM04419;	Family	ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [1] ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface.  It is thought to inhibit ATP synthesis by preventing the release of ATP [2]. The minimum inhibitory region for bovine inhibitor (Swiss:P01096) is from residues 39 to 72 [2]. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH , the inhibitor forms a dimer via antiparallel coiled coil interactions between the C terminal regions of two monomers.\	At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity [1].	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.46	0.72	-3.98	34	329	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	226	8	221	316	0	83.00	28	76.51	CHANGED	M......hphsh.........hp.....h.h.h.hthth.t.stGss..GAs.+uGG......tuGsuFsKREtApE-hYh+p+E+EQLtpLKc+lpc....pccclccL-ccIc	......................................................................h.....t..Gph.......Gus.+....ssG...................t.uG......s.uFuK+EtAp.....E-hYh+p+-+E.pLpp.L...Kc+hcc.......pppplcphpptlp...............................	0	69	114	179
+3033	PF01749	IBB		Importin beta binding domain	Bashton M, Bateman A	anon	Pfam-B_544 (release 4.2)	Family	This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates  formation of the importin alpha beta complex; required for classical  NLS import of proteins into the nucleus, through the nuclear pore  complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain [4].	23.80	23.80	23.80	24.00	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.55	0.72	-3.82	18	914	2012-10-11 20:00:59	2003-04-07 12:59:11	15	16	301	41	568	813	4	92.30	32	18.60	CHANGED	pssscsphRhppYKspu.hcs-EhRRRRcEstVElRKsKREEpLhK+Rplsh.tppt.p...psphsss.t...ssplppsh.h..pulhScD.ppQ.Lpusst	............................t....hsphRhppaKspu.hcs.........-EhRRR.RpE.sV...ELRK.sKR-E.pLhKRRNl..s......h.....p..p.......ss.s.p............tsp.pssh.t............pph...s....p.........h..............psl..S.ss.t.Qltusp.t.......................................................	0	157	244	397
+3034	PF03617	IBV_3A		IBV 3A protein 	Finn RD	anon	Pfam-B_3183 (release 7.0)	Family	The gene product of gene 3 from Avian infectious bronchitis virus. Currently, the function of this protein remains unknown.	25.00	25.00	89.10	89.00	18.60	17.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.99	0.72	-4.22	6	81	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	15	0	0	79	0	56.80	82	99.74	CHANGED	MIQoPTSFLIlLILLWhKLVLSCF+ECllALQQLIQVLLQIlNsNLQSRLlLWHSLD	MIQoPTSFLIVLILLWCKLVLSCF+ECVlALpQLIQVLLQIINSNLQSRLLLWHSLD....	0	0	0	0
+3035	PF03622	IBV_3B		IBV 3B protein 	Finn RD	anon	Pfam-B_3190 (release 7.0)	Family	Product of ORF 3B from Avian infectious bronchitis virus (IBV). Currently, the function of this protein remains unknown [1].	25.00	25.00	30.60	29.90	21.20	18.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.21	0.72	-3.99	7	88	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	17	0	0	82	0	63.20	73	99.30	CHANGED	MLsFEtlIETGEpVlQQISFsLQHISSVLsTplFDPFEsCYYRGGsaWElESA--hSGDDEahE	..............MLDFEsIIETG-QlIQQISFsLQHISSVLsTElFDPFEsCYYRGGsaWElES...AD-hSGDDEalE.......	0	0	0	0
+3036	PF03620	IBV_3C		IBV 3C protein	Finn RD	anon	Pfam-B_3232 (release 7.0)	Family	Product of ORF 3C from Avian infectious bronchitis virus (IBV). Currently, the function of this protein remains unknown.	25.00	25.00	25.50	58.60	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.05	0.72	-4.09	3	126	2009-09-10 22:14:47	2003-04-07 12:59:11	8	1	17	0	0	128	0	92.10	87	87.33	CHANGED	MhNlLuKSLEENGSFLTuVYVFlGFVALYLLGRALQAFVQAADACpLFWYTWVlLPGAKGTAFVYNaTYGK+LNNPELEoVIVNEFPRNGWNN	...hhNlLNKSLEENGSFLTAlYlFVGFlALYLLGRALQAFVQAADACCLFW.YTWVVVPGAKGTAFVYKHTYG+.K.LNNPELEuVIVNEFPKNGWNN...	0	0	0	0
+3037	PF04629	ICA69		Islet cell autoantigen ICA69, C-terminal domain	Mifsud W	anon	Pfam-B_5314 (release 7.5)	Domain	This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus [1]. Its precise function is unknown.	31.40	31.40	31.50	31.50	31.00	31.30	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.73	0.70	-4.40	6	145	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	51	0	70	148	0	173.60	37	43.48	CHANGED	PYEFTTLKSLQDPscKLspc...cK-cpppsspsusp.scpLISLE-t+..cEouo..s-cthu.lSuh-ch.hcsos.GAhD-LLDhKs-E.hhht..lPtDPLEPEsuDKDEhpLLN-ILSuSSL-suEhopEWAAlFGDP..pLtsPcP.ShGss-.-.+ssoSSGFLPSQLLDQsM+DLtuSlpsWsupptop.....sps.Psss.......QpPAK.......uupDLoAWasLFADLDPLSNPDAVGKTDKEHELLNA	.............................................................................................................................................................................................p.....t...p..t.......p....................t.hl.............t...........................................................................h......hss..c..-sh-K.-h.hLsplhss.uu...tpu-aopEhtssFG..ss........tp.t.s...shu.t..................tp.sotFLPSQLh......D..s..hp..htuu.h............................................................................p.pPtp..................u.spDhoAWFsLFADLDPLSNPDAl.G+o.Dc..ELLNA......................	0	10	16	34
+3038	PF03921	ICAM_N	ICAM_N-terminal;	Intercellular adhesion molecule (ICAM), N-terminal domain	Finn RD	anon	DOMO:DM01682;	Family	ICAMs normally functions to promote intercellular adhesion and  signalling. However, The N-terminal domain of the receptor binds to the  rhinovirus 'canyon' surrounding the icosahedral 5-fold axes,  during the viral attachment process [1]. This family is a family that is part of the Ig superfamily and is therefore related to the family ig (Pfam:PF00047). 	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.24	0.72	-4.51	5	218	2012-10-03 02:52:13	2003-04-07 12:59:11	9	28	36	23	89	253	0	89.10	36	19.09	CHANGED	pcsFpVpVcPcKslLssGGSlpVNCSToCspP-hlGLETsLsKchL-p.Gpu.WKtFpLSNVocDSshhCahsCuGsQpSuSoNITVYpsPEp	.........h.lplpPp.p.shV.h.GuSlhlNCS.T.s.Csp.P....p....h...h....G.LETp.LpK...p....ltp...Gsp...WttapL.s..slp..c..-.o.p.h.h.Cahs....C.u.s.p..Qpps.sssITVYphP-p.........	0	5	9	17
+3039	PF00818	Ice_nucleation		Ice nucleation protein repeat	Bateman A	anon	Pfam-B_2 (release 3.0)	Repeat	\N	20.80	20.80	31.80	20.80	15.40	20.70	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.76	0.72	-5.71	0.72	-4.50	110	1266	2009-01-15 18:05:59	2003-04-07 12:59:11	12	33	34	0	97	1330	0	15.80	74	44.84	CHANGED	GYGSTQTAGhcSsLTA	GYGSTQTA.utsSsLTA..	0	35	35	35
+3041	PF00656	Peptidase_C14	ICE_p20; 	Caspase domain	Bateman A	anon	Bateman A & Pfam-B_2524 (Release 8.0)	Domain	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.80	0.70	-4.68	115	4033	2012-10-03 02:24:44	2003-04-07 12:59:11	17	280	992	455	1901	4284	706	230.40	15	47.36	CHANGED	thALlIssspaspt..........sphpGstsDscslpphL.ppl.G.....apVps..........h.ps..................................................................................hotpphppt.lpphstptc.....ssD...shlhhhhuHG..tp........s..hsh.............Dsph..l...sl-t................lpshhpshps.sLtsKs+.lhllpACRusphspthttttstt............................................................................................................................................................................................................................tsshtphsstsDhlhhhuosssthShcs.................sspuShahpuLsphl......t.......hpltslhspVppplt................t.......................ttcQhPph.suhhpcphhh	..................................................................................................................................................................................hslll.s..p.ta..tt.....................tth......p...u..s.....t.D.s.p....tht..p...h..h...p..p..h....s...........a..psps..........h..ps.........................................................................................................ho.t.p.p.l.......hp......t...l..p..p...hhp.psp..............ssD...............shhhh..............h..........h..uH.G........tp................t.........t.h..................-sth......l..........sh-t...........................................lts......h.ps......h........s...t..........l....s..p...s....+...l............hh.l..pu....C...+.....u..s.s..h.....ph..h...h...t........................................................................................................................................................................................................................................................................................t....ht.t.h.....s.....s....s.h...l..h..h.h...u...s......h..s..s.....t...h.u.hcs.............................ttts...uh.ahptlhphl.....................................h..phh....ht.tth..............................................................h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	653	1049	1463
+3042	PF00463	ICL		Isocitrate lyase family	Finn RD	anon	Prosite	Domain	\N	19.50	19.50	19.50	19.50	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.93	0.70	-6.29	7	4174	2012-10-10 15:06:27	2003-04-07 12:59:11	16	13	1846	69	1148	4424	4281	225.10	28	93.61	CHANGED	EVtElcKWWossRW+tTKRsYoAEDIss+RGsl+.lpYsSs.tAcKLa+lLcc+ptptssShTaGsLDPstVoQMAKYLDolYVSGWQsSSTASoSsEPuPDLADYPhsTVPNKVEHLahAQLFHDRKQpEERhphscpc..Rtph.s.lDYLRPIlADADTGHGGlTAlhKLTKhFIERGAAGIHIEDQusuTKKCGHMAGKVLVPlQEHINRLVAIRhpADIhGo-LLslARTDuEAATLITSoIDhRDH.FIlGsTNPsh..tsLsslMstA.htGtpGspLtslEs-WhtKAsLKhFpEAVlDtIptus...hsNKpthltca.ppsp.hpphst.EA+tlAcclhGp-IaFsW-hsRsREGaYRapGGspCulsRuhAaAPYADLIWMESphPDatQA+EFA-GV+utaPcQhLAYNLSPSFNWppAMssD-.QcTaIpRLucLGYsWQFITLAGLHTsALhscsFA+sYup.pGM+AYuppVQpP...EhcsGV-VVpHQKWSGAsYlDtlL+hlpGGVoSTAAMGtGVTEDQF	..........................................................................................t........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	314	663	947
+3043	PF03517	Voldacs	ICln_channel;	Regulator of volume decrease after cellular swelling	Griffiths-Jones SR, Coggill P	anon	PRINTS	Family	ICln is a ubiquitously expressed multi-functional protein that plays a critical role in regulating volume decrease in cells after cellular swelling. In plants, ICln induces Cl- currents [1,4,5], thus regulating Cl- homoeostasis in eukaryotes [2,3]. Structurally, the fold resembles a pleckstrin homology fold, on of whose roles is to recruit and tether their host protein to the cell membrane; and although the surface charges of the ICln fold are not equivalent to those of the PH domain, ICln can be phosphorylated in vitro and the PH-nature of the domain may be the part involving it in the transposition from cytosol to cell membrane during cytotonic swelling [1].	22.10	22.10	22.20	23.30	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-11.14	0.71	-4.32	115	359	2012-10-04 00:02:25	2003-04-07 12:59:11	8	8	280	1	243	349	2	133.60	25	52.92	CHANGED	GsLalssp.plhWh.s.............t...............................spGhulsYsuIoLHAlp+.........................shsp.slYhQhp.....................................................................ttssspsssppsppsssElpllPsss................................st......lcslapAhspCus.LpPDss.......t-pptp...t..tptptp.shhhps	....................................ssLalspp....plhWhs.........................................................sshGhul.YssIoLHAls+..t......................shsp.slYh.ls...............................................................................................................t........ttptpppssc-ptpthsEhpllPsst....................................sp...........lcshapAhspCps.LHPDPp...............sp-s.-cc....t...............ttth.......................................................................................	0	73	122	187
+3044	PF04140	ICMT		Isoprenylcysteine carboxyl methyltransferase (ICMT) family 	Wood V, Finn RD, Bateman A	anon	Pfam-B_15304 (release 7.3) & Pfam-B_5114 (Release 8.0)	Family	The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.26	0.72	-3.79	12	1448	2012-10-01 22:51:20	2003-04-07 12:59:11	9	8	1272	1	481	2287	1176	94.30	31	44.00	CHANGED	hlsh..hlhuphhRhhshhohGphasp+lhh..hssHplVpsGlYpalRHPsYhs.hhhplus.sLlsss..huhlhhshsshhha..RIcpEEpsLhp	.....................................hsh..hl..hlhu....h.hhh.h..sh..p.p.L..G.p..h..W..o...h.+........l..hl..........hss..H...p.lV..s...pGlY+..hh+HPsYh..h...............l.....l.........p....lh...s....h.h.....L...L...s..p...u.....h.......h........s....s.....l...l....h.....h.s.....h.....h....s..h...h.La..hR..I..c.p.EEphL..t.......................................................	1	166	278	396
+3045	PF03971	IDH		Monomeric isocitrate dehydrogenase	Bateman A	anon	COG2838	Family	NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes [2].	25.00	25.00	27.90	27.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-13.26	0.70	-6.17	5	1265	2012-10-02 21:08:39	2003-04-07 12:59:11	9	3	1189	11	297	1040	630	682.90	61	98.77	CHANGED	TIIYTlTDEAPALATYSLLPIV+AFAcsAGIcVETSDISLAGRILAsFPDaLTE-QRVsDsLAELGELspoPDANIIKLPNISASVPQLKAAIKELQ-KGYAVPDYP-DPpTDEEKAVKtRYDRIKGSAVNPVLREGNSDRRAPtAVKNYARKaPHSMGAWSpsSKSHVAaMcuGDFFuSE+ShTlucAssV+IEFluK-GsVcVLKcpVALp-GEIIDosVMSKKALtsFaEcQlpDAKupGVLFSLHlKATMMKVSDPIIFGHAV+VFYK-VF-KaG-LF-pLGVNVNNGlGDLYAKIcSLPAuQRsEIcADIpAVYA+pP-LAMVDSDKGITNLHVPSDVIVDASMPAMIRsSGQMWGsDGKtKDTKAVIPDSoYAGVYQslIDFCKpHGAFDPTTMGSVPNVGLMAQKAEEYGSHDKTFElsADGVVRVl.DAsGcVLhpHsVEAGDIWRMCQTKDAPI+DWVKLAVTRARlSsTPAVFWLDPsRAHDsELIKKVcpYLKDHDTsGLDI+IMSPlEAh+aSLsRL++GpDTISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMAGGGMFETGAGGSAPKHVQQllEENHLRWDSLGEFLALAASLEHLGlKTGNsKAKVLAKALDsATGKLLDNNKSPSRKlGELDNRGSHFYLAhYWAQALAAQs-DA-LpA+FAPLAKALTEcEAsIVAELNuVQGKPuDIGGYYAP-s-+sAsVMRPSsTFNAAL-u	......pIlYThTDEAPuLATYShLPIlcuFspsAGIsVcTpDISLAGRILAsFP-hLsE.....-Q+lsDsLAELGELsppP-ANIIKLPNISASlPQL+AAIKELQspGYslP-YP-.-PpoD....EE+pI+ARYsKlhGSAVNPVLREGNSDRRAPtuVKsYA+KpPHp.M.G....t.W.ot.s.SKoHVApMp.pGDFausEKShsl......s..p..usslcIEh..l....sp....c....G.s...p.pVLKpslsLpsGEllDuo.hMStcALppFhtcpltcAKpp.sVLFS.LHlKATMMKVSDPIlFGHAV+lFa+-lFsKauchhcplGlssNNGlu-lau+lp.s.L.Pssp.psEIpusl....pusa.s..p..pPsLAMVsSDKGITNLHVPSDVIVDASMPAMIRsuG+MWss-G+.pDTpAVIPDpoYAslYQssI-.C+ppG.AFDPsTMGoVPNVGLMAQKAEEYGSHDKTFpl.stsGslcll......s......t......s....GpVL..hpppVEtGDIWRhCQsKDAPIpDWVKLAVsRARhossP.......AlFWLDtpRAHDsplIpKVppYLt-....H.....D....TpGL...-IpIhuPh-AhpaoLcRl+cGpDTISVTGNVLRDY.LTDLFPILELGTSAKMLSIVPLMsGGGhFETGAGGSAPKHVpQhlcENHLRWDSLGEFLALusSLE....alu..pp..s......s..NsKAplLAcsLDpAsuchL-ssKSPuRKlGE.lDNRGSHFYLAhYWAptLAtQscDs-LtspFuslAptLspsEppIlsELs.ssQGpssDlG..GYYtsDst+sstsMRPSsThNshlp.s............	0	77	185	259
+3046	PF01231	IDO		Indoleamine 2,3-dioxygenase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.40	0.70	-6.05	39	516	2012-10-01 19:57:26	2003-04-07 12:59:11	13	11	214	4	368	501	538	358.10	28	79.96	CHANGED	s.h.sLp-YtlS.cpGFLPtp.PLccLP.-.YYpsWEpls...psLPsL.............lts.+plRphV-.plPlLsssp.L....psct.EhRRAYhlLuFlsHuYlWus..spPpc.....................................hLP.sluhPhlclSccLtLPPlhTYAulsLWNa+......htss......shhsh-NL..sslpoFTGohDE.pWFaLVSVhlEtcuu.slphhlsulpAsp.ts-p..ttlspsLpplupslcclsplLpRMaEps-PplFYaplRPaLuG.KsMsshGLP.pGlhY.................-....uspsp.+p...YuGGSNAQSSLIQhhDllLGlcHpssu...............................................................pssFlpEMRpYMPssHRcFLpclpp...................................ssslRpYVhsppsst...tLptAYssClttLpsFRDpHIQlVoRYIlhsu+cst.tt.s.....................................ppcsssht.+GTGGTsLlPFLKQsRD-Ttcssh	..................................................................................httatls.ppGFls.................P..l..p..pLP.......apsWpplh....ppl..sth...............................l.s...tplRt...h.l.c....ph.....P.hL..s..s..pt...L...........pspt...thptA.ahh.....L.......ualspuY..l....at...t........ppstp..............................................................hLPtsluhPhhplup.............p.............Lt.l.P.P.hh...s.Y.A.s.hs.....L.hNap......h...hsss.....................t.h.phcNl.........phl.h..sFps....s.....sE...phFhLlslhhEttuushlphhhp..slp.......u.......hp....psst...............ttlhpsLppltpslpc.ls.th...hppM.........hc...t.......s.cPp..haYtplR.s.altG.......p..s....t...h.....P...pGlhY...............................-.......s.s.p...t..p.hp.....apGsSsAQSSllp..hhDhhLslp.c.ss.....................................................................................ttalp-hRpYMPssH+pFLptl.pp..........................................ss...lRp..hs....t..........ptsp..................tlt.sYstslttltthRstHhphspcYIlh.upp..........................................................................................sout.s....hl...h........h........................................................................................................	1	115	201	288
+3047	PF02479	Herpes_IE68	IE68; 	Herpesvirus immediate early protein	Mian N, Bateman A	anon	Pfam-B_2276 (release 5.4)	Family	This regulatory protein is expressed from an immediate early gene in the cell cycle of herpesvirus. The protein is known by various names  including IE-68, US1, ICP22 and IR4.	18.70	18.70	18.70	20.30	17.90	18.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.59	0.71	-4.95	13	78	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	36	0	0	68	0	125.40	39	38.87	CHANGED	+sEYGssssstphRs....s+usGuFCussWpPDlsRLspDlNplFRsIspuuhsssssscsLRRsLhDhYlhGhsptR.s.ssWEpLLQLoPsQ.otsLRsTLR-lspRsststc.lpsssplstphaGsECDVS	.............................Pp.usssssthlR.....sRtstthsussWpPDlshlppslNpLFR.lhpsuhcspssuppLRRhlhDhYLMGYs+tRLs.psWppLLQlostp.uhpLRsTlR-lpuR.ststc.l..pt.ssl.sphaGsECDls.......	0	0	0	0
+3048	PF01008	IF-2B		Initiation factor 2 subunit family	Bateman A	anon	Pfam-B_1302 (release 3.0)	Family	This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterised as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The  crystal structure of Ypr118w, a non-essential, low-copy number gene  product from Saccharomyces cerevisiae, reveals a dimeric protein with  two domains and a putative active site cleft [2].	22.40	22.40	22.80	22.70	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.63	0.70	-5.42	18	3047	2012-10-04 00:26:15	2003-04-07 12:59:11	12	22	1567	43	1662	2957	1606	282.00	28	77.40	CHANGED	pl+GusslulsuhtsLhhhhpctp...hspsp-h.........hpplppthshLtsoRPouVsltsulchlhp...........tpshppscps.......................................llcpupphlp-.shpssptIuphutchI.........cDu-sILTas.sSus........sluVlpp.Ahppu.................+ch+VlssEoRP.thQG.+lsshpLhptGIsVTLlsDoulualMpc....lDpVlVGA-sIhpNGs.lhNKIGThplAllAKppslPFaVsA.phKFs.chthspplhhEtcsPpElhhhsssphh...................................................................slplhNPsFDlTPs-hIohlITEhGslsP	........................................................................................................................................lcGusshulsush.u....lh....h........h.....h....pp...h.t.............p.....t.t..h..................................hptlp...pth.p........hL...t..........s.........s......R......P.....o...u...l..s.....l.h......u.l.cp.hhp............................................t..t.....t...s....h.p..p..h...t...p.t.................................................................................................................................................................lh.ppup.p.h....h....p-....shts.scpI...u.p.h.u.h..p.h.l..................................p.s...s......t..s..lLTas..sous...................sh.u.s.lht..A...t..p.p.s....................................p...t..h...c.V.h.......s......s............E.....o......R.P....h................h.........Q.......G.....+...........h........o.A.................h.c..L.............t..........p..........t................G.................I..s..............s.TlI..s.D.s.s.s.uh..l.Mpp.................l....stV........lVG.ADpl.s.s.NGs.lsN......K......lGTht..lA.l..hA.........+...t........a.......s..............lPFhVsu..ss.phsh.p..h......s...s....p........p....l............l.......E.....+.s...s.p.E.l..h....p...h....t....s....t....p..h...s.s.t...................................................................................................................................................................s.hp.s.h..N.P....s.FDlTPschlo.u.llTEhGlh..............................................................	0	560	982	1379
+3049	PF00707	IF3_C	IF3; 	Translation initiation factor IF-3, C-terminal domain	Bateman A, Finn RD	anon	Pfam-B_629 (release 2.1)	Domain	\N	20.90	20.90	21.10	21.90	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.86	0.72	-4.24	150	4680	2009-01-15 18:05:59	2003-04-07 12:59:11	17	5	4531	3	1156	2821	2168	87.80	44	49.92	CHANGED	hlplKEl+hpPpI-cHDhpsKl+psp+FLcc.GcKVKlolpFR...GREhs+t-.lGtclLp+htpcl..p-luplEptP.+hEGR...pMhMhLu.P+p	.......h.lplKEl+h..pPsIDcpDapsKl+ssh+FL.-c.......GD...K.....VKlol...R...F.R....GR.....E.h..s....Hp-.......lGhclLp.Rltc-l....p-.lA...h...V.EptP..Kh..E.G.R...pMhM.lLA..P+................................................	2	397	751	978
+3050	PF01652	IF4E		Eukaryotic initiation factor 4E	Bateman A	anon	Pfam-B_1315 (release 4.1)	Domain	\N	21.00	21.00	21.50	21.20	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.19	0.71	-4.71	135	1579	2009-01-15 18:05:59	2003-04-07 12:59:11	13	11	412	47	834	1511	155	157.30	32	65.03	CHANGED	PLpppWohWap........stssp.......................tpsapssL+.l..............ssFsoVEcFWulYspl..P.ocLshts-a...............alFKcGI.+P.hWEDstNppGG+Wh..hphp..........................+p..........................ph-chWhchlLuhIGEph..pts...................--lsGlV....ls.lR..t.ptpp...............lulW.s+ss.....................ssppshhpIscpl+..chL..plssp..........h....papsH	..........................................................PLpppWshWa..............tt..s.p....................................................spsap..ss.l.+...l...............................tsFs.o.VEpF...W....s.lYs.pl.....hs.....o..pL...sh....t...s..Da........................a.lFKc..G..I.c...P..hWE..DstNtp.GG+Wh..lphp............................................Kt.................................................thDphWhch....lLuhI.GEpF..pps...............................--l.CGsV.......l..s..l.R.....t....ptc...p........................lulW.s+ss.....................ps.pt....s.h.....h.pItcph+.chL..ph..p......h...................................................................	0	326	467	676
+3051	PF00932	LTD	IF_C_term; IF_tail;	Lamin Tail Domain	Finn RD, Bateman A, Anantharaman V	anon	Anantharaman V	Domain	The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated  hydrolases of the metallo-beta-lactamase,synaptojanin, and  calcineurin-like phosphoesterase superfamilies [1].	25.70	25.70	25.70	25.80	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.43	0.71	-4.01	51	1619	2009-09-10 16:30:14	2003-04-07 12:59:11	14	164	831	14	675	1585	960	119.30	18	18.47	CHANGED	sssssssssssslhls-hstsusss..........calElhNsus.pslDLsGaplpcp.......ssphthhssshh........sGpslhlhtsss..........tt...thhhttt...ssasst...............s-slsLhsss..Gphlsthshsstss	.......................................hs........stsplhIsE..h.......s.u.....t....................calclh..Nsu....s...psl....sL..u..G....ap..lppp....................sssh..p.hs.sshhhh..................suph.l.slhssss...........................tts.sphhhptp.......hshsss...................................ssth.h.Lhssp......G.p..l.s.ht......t..............................................................................................................	0	248	401	556
+3052	PF00714	IFN-gamma		Interferon gamma	Bateman A	anon	Pfam-B_615 (release 2.1)	Domain	\N	20.30	20.30	20.60	26.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.75	0.71	-4.34	9	229	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	125	13	27	233	0	123.10	50	85.86	CHANGED	lLusSGsYCQusah+ElEsLKpYFNASssDVu-GGsLFLDIL+NWKEESD+KIlQSQIVSFYFKLFEsLKDN.QsIQ+SM-sIKpDhhsKFFNuSpsKhDDFp+LhphsVsDLpVQRKAlsELI+VMs-LSPcSsLRKR	...........................h.c-h-pLKtaF.Nuups...DVucu.GsLFl-ILKNW+...E.-uD.+KIIQSQIVSFYhKlF-.N.h.K..Ds...QhIQ+ShcpIK...EDh...h...s..+....F...h.N.uu.ppKhcDF.p+LhplsVsDLplQRKAlsELhpVhp.cLS..P.tuphtK...........................	2	1	2	7
+3053	PF00047	ig		Immunoglobulin domain	Bateman A, Sonnhammer ELL	anon	Bateman A	Domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases.  Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.98	0.72	-3.85	52	1594	2012-10-03 02:52:13	2003-04-07 12:59:11	20	231	155	48	526	42115	2	63.00	21	11.35	CHANGED	GsssslsCps.....tss.tsphpWhppspthtpttpsth..tt.............................lplsssp.p.cuGsYtChs	..........................................................pslpLsCps...................t.s.....s....t....h.p......W....p......p.......p......s.....p.......s.....h....t......t......t......t....h....t...t....t....p...h....t..t.................................................................................Lh.l.s.s..s......s..............p..cuG.s.YpCh.........................................................................................	1	144	166	265
+3054	PF02395	Peptidase_S6	IGA1; 	Immunoglobulin A1 protease	Bashton M, Bateman A	anon	Pfam-B_540 (release 5.2)	Family	This family consists of immunoglobulin A1 protease proteins.  The immunoglobulin A1 protease cleaves immunoglobulin IgA and is found in pathogenic bacteria such as Neisseria gonorrhoeae [3]. Not all of the members of this family are IgA proteases Swiss:O32555 from E. coli O157:H7 cleaves human coagulation factor V [2] and Swiss:O88093 is a hemoglobin protease from E. coli EB1 [1].	19.70	19.70	19.70	19.70	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	769	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.74	0.70	-13.53	0.70	-6.41	9	1016	2012-10-02 13:45:52	2003-04-07 12:59:11	11	15	370	10	37	880	2	454.70	25	57.43	CHANGED	huhssh..uhAupsp.s.lsYQhaRDFAENKGhFpsGATNIplhsKpGphlG..hhstsPMhDFSsVsss.Gl.....ATLlssQYlVoVpHNu.GhsslsFGs.Gp.................spYphVc+NNhts..................DaphsRLsKaVTEstPsssosshssussYpsppRYsshhRlGuGpQaltp+s.............Gptsphsu.uYpahsuGostt..............uhtNuphhhus.ssstshp.hs........sLsshushGDSGSPLFsYDspcpKWVllGslpshssa.tts.t..slhpppFhsph.pcDpsu.lpt.s...sslshp....ssssGsGslT......pGSp......shchtsppss......................hNtGKsLhFpGt...GslsLpsslsQGAGGLhFcsshphpssss...shTWpGAGIslscGsoVsWpVpsspsDpLpKIGcGTLpVpGsG.NpGuLKsGDGpVILsQQADstsphQAFSpVsIsSGRuTVhLNsspQlsPs.slhaGFR..GG+LDLNGpsLTFc+IpssDpGAhIsNp.os+pSslTlss....ss.IstP............s.s...........h...t.h...hp....pp.phhhLctus.s......s...pss.h.h.G......pppshs+hp.t+htsas..haFstp.ssshsssl.hhhpGps..hhhh.sussNhcGslopppGsLhhoG+Ps.HA....sht.t...........pspslsppDW.NRsF+hcslplcsushhlS..psuslpusIpAo.NuslslG..ssp..hspscuc..TG.hshshctslosscslss.sh..hsGslsLsppus....pthstGltuhsus.plo..spuhashsss	...................................................................................................................................................................................................................................................................................................................................................................................................................t.pa....hp.....t.p...h...t.......................................................s..........................................tt....................t...........h......GDSGSshahast..tpW.h.u......................................................................................................................................................................................................tpsh.h.......t........t..l....h.pth...p.G..u..l.Ft...t...t..h....t...t..h.GuGl.httt..l.Wth........................t....................tD.LtKhG.GsL.lp.h.......t..p.stlphGpG.VlLttp........sFspl.hs.uGpshl.lst....tpth....................t.t........hh.t..GGhL-hsG.s..Fp..l.....s.ts.l.st..............h..............................................................................................................................................................................................................................................................................................p.-W....F.ht..h.h...t..............................................................................................................................................................................................s.................................................................	0	13	18	27
+3055	PF00219	IGFBP		Insulin-like growth factor binding protein	Finn RD	anon	Prosite	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.00	0.72	-3.42	54	1051	2009-09-11 00:39:06	2003-04-07 12:59:11	13	24	116	8	458	832	0	54.50	44	18.34	CHANGED	Cs.....sC..p....C.P..............s.sPsCs.sVp...sGCGCChs..CA+p.......hG-sC......shpshC..spGLpC	......................Cs...sC..p.......C..P...................ss..s.sCs...sVp......-GCGC.Chs..CApp........G-s...C..........s...s.h....s...s....h.C..upGLpC..........	0	48	94	234
+3056	PF01378	IgG_binding_B		B domain	Bateman A	anon	SCOP	Domain	This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.	21.20	21.20	21.20	21.20	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.53	0.72	-4.16	4	50	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	18	74	4	119	0	53.60	73	27.86	CHANGED	TYKLllpGpThpGETTTKAVDAATAEp.sF+QYANsNuVsG-WsYDsATKTFTVTE	.......TYKLVlpGpT..hpGETTTKAVDAATAEK.sFKQYAN-NGV.DG-WoYDDATKTFTVTE...	0	0	0	2
+3057	PF00475	IGPD		Imidazoleglycerol-phosphate dehydratase	Finn RD	anon	Prosite	Family	\N	20.30	20.30	20.60	24.10	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.79	0.71	-4.34	146	3695	2012-10-03 01:04:38	2003-04-07 12:59:11	13	12	3613	24	1011	2611	2275	144.30	51	57.73	CHANGED	TGlsFaDHMLsthu+HuthDLplpupGD...lclDs..HHTVEDsGI..sLGpAlpcALGDKpGIpRa.................GsuhlPMDEuLs............psulDlSGRPalsac..sph.p.tp.lGs....hsoEhlccFFcuhu.sutlTLH.lphhhGc......NsHHhhEAhFKAhu+AL+	.........................................TGVGFaDHMLctlApHGthcLplpscGD..........Lc...ID-.....HHTVE.DsGIsL...Gp.AlppA.LG....D...K.....+...GIpRa.................Gs.hh...lPMDEsLu..........................psslDlS.....GRPaLsac............spas.....p....p+...l.Gs..............hsTEhlccFFculuhsutl.TLH.l.c...sh..Gc......NsHHhlEu..lFKAhuRALR.................	0	330	666	867
+3058	PF00218	IGPS		Indole-3-glycerol phosphate synthase	Finn RD	anon	Prosite	Domain	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.44	0.70	-5.33	20	5164	2012-10-03 05:58:16	2003-04-07 12:59:11	16	18	3907	23	1085	4373	2572	228.50	40	76.40	CHANGED	Lp+Ihsp++tcVsst+pp.s...uclpt.h..t.sssspuFh-sLpp....tpsulIAElK+ASPSKGhIc.-hssschAcsYppuGAusISVLT-scaFpGuh-hLtplRpslslPsLp........KDFllDpYQIhEARhhGADslLLIlusLs-pp..hpcLhphApuLGM-sLVEVpstpElcRAL.tlGA+llGVNNRNL+oFcVDLssTpcLsshls.......t-.slLluESGItotpDlcphpcpGscuhLVGEuLM+ssDhcttl+cL	..........................................................................................................................LtpIhttpt..ltth...p.t...s.....t.h.t.h................................h...s......h..h..tsLpt..................tt...h...shIsEhK+AS...PS..c.....G........l....p...............p.....h....s....s......thAt.....Ypp.h....t........AsslSVLTDpcaFp...............GSh-........Lptl.p.....p.....t.....s.....s......h.....Pl.Lp......................KDF.IIDsaQIh.ARhhGADslLLhl..u..sL...........s...D.........c...p...........hp...cLhshA.c.s.LsM..s.VLlE.VpsppE...l-...R......Al...pL.......s.........s...c..........l....IG...I.N.....N...R....s....L.........+..T..h..p...s.....D........l..s.....p......T....h.....cL...t.....s.....hlP..........................cs...t...lllSESGIhotsplctl.t.th....ssuhLlGpulMpt.ts..ttthtt............................................................................	1	350	707	929
+3059	PF05049	IIGP		Interferon-inducible GTPase (IIGP)	Moxon SJ	anon	Pfam-B_5519 (release 7.7)	Family	Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localises to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing [1].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.15	0.70	-5.65	6	355	2012-10-05 12:31:08	2003-04-07 12:59:11	8	11	60	8	235	584	54	294.00	31	78.44	CHANGED	SsEllptIcpAlcEGpLpcllShIc-slpslspshlcIAVTG-SGsGhSSFINALRsIGHEE-sSAPTGVVcTThc+TsYpp.s+aPpVhlWDLPGlGuTs.os-oYLEEMpFupYDhFIIIuSppFSpNclcLApsIppMtK+FYhVhTKlDpDLosp......oFsc.clLQsIpcNhpssLQcstVpEPPlFLlSshcsspaDFPcLc-TLhKDLPshKpHshhhoL.sls-psIspKtpsLKp+IhL.EuL+uuhls........tssDhsNhccshKsYRphFGlDDtSLpplApchsh.ltchcsph+u.phashpc--pllcphhphhlptFhtlht......hh.sssshh+chhapphhFL-hVApDAKslLcKI	...................................................ht.thtp.tp....s.h.shlp..p.h..l......t.t..h..p...p......s.......l.pluVsG-oGsGKSShINA.l....R.G....l....s.p.-...-...c..s..u.....A..T..G......V......l.......E....T....T.........h...........c...........s.....s..Y..............a....P..............p.........h...P......s...V..tlW.DL..P.......G.........h................G...........o.........s.....s..........h..............s........c..........p........Y.......L.p..p..h..p..F........tp......Y.....D......h.........F...I..l...l..u...u...p.R..F.p....t.s..-...s.pLA.....ctI......p.....p...h....t...K..p..F...YaV...RoK.............lD....p..D.l...ts..........p.t.....t......p...........p.s.a..s......c.....p....p..h...Lp..p....IR....pp...shp.......pLp......p...t....tl..pps.lFLlSs.h....p....tta.DF..L.psl.p-Lsth+pph.h.....h.slsshs.thlppKtt.hppplhh..uhhssh.t...............c.t.h.t.hp.Yp..FGlDc.Slt.hupphth...tp.hp..hc..............................................................................................................................................................................................................................................................	1	49	83	136
+3060	PF00340	IL1	interleukin-1; 	Interleukin-1 / 18	Finn RD	anon	Prosite	Domain	This family includes interleukin-1 and interleukin-18.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.59	0.71	-4.65	16	589	2012-10-02 19:42:32	2003-04-07 12:59:11	14	3	132	42	189	614	0	110.80	26	54.99	CHANGED	hpspshpppshFsMshhpsp.psstlPVs..LuIcsppL.aLSC.pc.spssLphEts-.P+hhsspcp-hhFhFp+ststspsp...FESutaPsaFluTpp-pp..h.Lsph.ttps.lTDFph	...........................t........t.hh.h.....h.....p.........t..t....t..s...p..t.....h.PVs..L.ul..p...sp...p..h..hLSC...t..p..p..t...s..p.....P.sLpLc..cs....c...h.....c.........h.....s..p...p.cp..s.....t.......h..FhFh.+pp..suspsp....FESutaPuWFluTsp..ps..p........l.lsp..t...t...............t................................	0	9	13	38
+3061	PF00726	IL10		Interleukin 10	Bateman A	anon	Pfam-B_885 (release 2.1)	Domain	\N	24.20	24.20	24.50	24.50	23.80	24.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.00	0.71	-4.96	3	341	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	126	14	83	316	0	146.60	36	93.10	CHANGED	ALLpCLVLLAGVtsSRstYstsESuCTHhPsShPHMLRELRAAFS+VKTFFQpKDQLDNLLLT-SLL-DFKGYLGCQALSEMIQFYLEEVMPQAENHGPEIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKNsFNKLQEKGVYKAMSEFDIFINYIEAYMTI	................................................................................................................................................hs...hLp-LRssFpcl+s.h.hQh..cD.p.hp.s..l..LL..pps.l..l.pphKuhh..G..CpshschlpFYL-c.V.h.Ppu....pp....p....s............s....c..l+..c+lsS...lupphpo.L+h..c.LR..pC...+...p....ahs.C...c...s...+..s...c...u...lp...p...l.+...p...sa.pcL.p.p....p.G.l....hKAhuEhDlhlsalE......................................	0	4	8	25
+3062	PF03039	IL12		Interleukin-12 alpha subunit	Mifsud W	anon	Pfam-B_2071 (release 6.4)	Domain	Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit (e.g. Swiss:P29459) and a 40kDa beta subunit (e.g. Swiss:P29460). It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit.  On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses [1,2].	25.00	25.00	25.60	27.60	23.60	24.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.44	0.70	-5.23	3	97	2012-10-02 01:28:15	2003-04-07 12:59:11	9	3	54	2	30	88	0	172.50	47	88.05	CHANGED	MCP.uRsLLLLATLVLLN...HLSLARsLPsSTsGPuh.t+CLNpSQNLLKTVDssLQsA+EpLEaYSCTAEEIDHEDITKD+TSTVKACLPLELApNESCLAoRETShIT+GSCLTSGKTSaMTTLCLSSIYEDLKMYQlEFQAINAKLLMDPKpQIaLDKuMLsAIDELMQALNaNuETVPQKPS..lsEuDhYRTKhKLCILLHAFRIRAVTINRVMSYLNSS	.....................................................................................lhlshLsLL........Ls.shsLPss...s.....h.sLphSpsLLpsssphL.pKA.+QtLchYsCTsEElDHEDIT+sposTlcACLP.ELhhNEs....C.Lsopch.S...hp...pGpCLsot..+.oSahhsLCLpSI.YEDLKhYpsEFpshstt.LhhpscpQlhL..DpshLssIp-LMQu..LNh.s..u...c..sl.sp.psu........hp.c.c.Y+s+hKLCllL+AFplRsVTIsRhhuYLsu...........	0	1	2	12
+3063	PF02372	IL15		Interleukin 15	Bateman A	anon	Pfam-B_2545 (release 5.4)	Family	Interleukin-15 (IL-15) is a cytokine that possesses a variety of biological functions, including stimulation and maintenance of cellular immune responses [1].	28.50	28.50	28.60	30.10	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.04	0.71	-4.37	14	168	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	53	22	54	152	0	126.90	31	84.55	CHANGED	VhIhuClSAulPpTEAs...Wp........sVIpDLcpIEplhpSlHlDsoLYT.poDs+.pCphpshpCFLLElpVIL+Ep..csssIccplcNllhhusssLso..ptssTtstCK.CEEhEcKNhsEFLQsFs+llQhFlp	...........................................hh.Ch.shh.tTpAp.....hp..............plIpcL..cplcshl..psh.ch-.........hLYT..so.Ds........c....p.CphouhpCFhhEl.Vllc.Es...ssspl..pcplpsllh.hspsL..s..s........t..tp.hs...p.s..sCp.pCEphE.cKshpEFLpphhpllQh...................	0	2	4	16
+3064	PF02394	IL1_propep		Interleukin-1 propeptide	Bateman A	anon	Pfam-B_1500 (release 5.2)	Family	The Interleukin-1 cytokines are translated as precursor proteins.  The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.	21.30	21.30	21.50	22.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.67	0.72	-3.65	23	206	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	87	0	40	195	0	96.10	34	38.57	CHANGED	MApVP-Lhp-hhshYS-.pp-hhaEhDt.shhppsF.DhshssLt....DpslpLphScpphsp..oF+psVsllVAs....-cL+Kh.lshsQsFpDDDLculhsslFEEEsI	.........................MAhVP-h.p-.hsh....hS.......-.pp-.h...t.Dt..p..p.psh.D...hshssh.................cpslpLplScpptsp..oF+.....psVslVVAh....cKL+..+......hshspsFpD-DLpu.l.hsp.lFEEE.l...............	1	2	2	8
+3065	PF00715	IL2		Interleukin 2	Bateman A	anon	Pfam-B_709 (release 2.1)	Domain	\N	25.00	25.00	25.60	25.60	24.60	20.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.02	0.71	-4.47	7	151	2012-10-02 01:28:15	2003-04-07 12:59:11	12	2	76	47	19	164	0	124.30	65	94.53	CHANGED	LSCIALTLsLlsNSAPTSSS..............s+pTQppLEpLLLDLQhLLptlpN.cNsKLoRMLTFKFYhPKp.ATELKHLQCL.EELKPLE-VLsLsQSKNhp.p...hK-hhSNIpVTVLcLKGSETpFpCEYDDETsTlVEFLN+WITFCQSIhS	.......LSCIALoLsLlsNuAP.T.SSS...................TppTppplcpLLLDLQhLLptlpN.cN.KLoRMLTFKFYhPKp.ATELKHLQCL.EELKsLEEVLsLApSKNhphpc.......h+-.hsNIplhVLcLKGSETpFpCEYDD-TsshVEFLN+WITFCQSIhS..	0	1	1	2
+3066	PF02059	IL3		Interleukin-3	Mian N, Bateman A	anon	IPR002183	Family	\N	25.00	25.00	25.80	30.50	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.58	0.71	-4.11	5	41	2012-10-02 01:28:15	2003-04-07 12:59:11	10	1	25	2	11	36	0	113.60	47	79.56	CHANGED	Au.oposol+soRTs.CSslhcEIls+Ls...lssps.ssLNuDDpshLpcsoLRRsNL-sFhppAs-ohssD.osIcSsLKcLpsCLPsATssSspcPIaIKDtDhsDFR+KL+FYLlpL	.........As.sQshsl+Tohsp.CSshlcEIlscLpp.slP..s.ssLNs--psILhcssLRRPNLEAF..pAscohp..Nu.SuIcS....LKpL.PCLPhAT.ssPspcPIpI+DsDasDFR+KLcFYLcsL.	0	1	1	1
+3067	PF00727	IL4		Interleukin 4	Bateman A	anon	Pfam-B_833 (release 2.1)	Domain	\N	20.50	20.50	20.70	20.50	19.50	20.40	hmmbuild  --amino -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.70	0.71	-4.23	8	198	2012-10-02 01:28:15	2003-04-07 12:59:11	13	2	92	24	28	186	0	84.40	48	78.13	CHANGED	pch-hsL+EII+TLN.lTs+.cssChELsVsDVLuAsKNTTEKEhhCRAopVLRphYp+H...............pposlhphLptLDRNLsuLAst.oCoVNEuKpoT..LKDFLERLKoIM+cKYS	......phcIsLpEIIKTLNhLTsc....Ks...sChEL..sV.sDhhsss.K.ssscpEhhC+AuthLpph...p+....................tt..h...h.lttL.psh.uhsth..sCssptsp.......hpphL.tL...............................	0	1	2	3
+3068	PF02025	IL5		Interleukin 5	Bateman A	anon	PSI-BLAST P05113	Domain	\N	21.90	21.90	22.20	25.50	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.47	0.71	-4.05	6	60	2012-10-02 01:28:15	2003-04-07 12:59:11	10	1	46	8	18	50	0	105.40	63	84.89	CHANGED	AlEuPMstLVtETLsLLSTHRTLLIGstsLhIPsPpHKNHQLCIEElFQGIDTLKNQTsQG-AVc+LFpNLSLIKcYIDhQK+KCGtERhRVKQFLDYLQEFLGVINTEWThE	..........................hE.shstLVtETLsLLSoHRTLLIustsLRIPsPsHKNHQLCIEElFQGI-TLKNQTspGssV-+LFQNLSLIKcYI..Dt...Q...K+.KCGtER+RV+QFLDYLQpFLGVhNTEWhhE......	0	1	1	2
+3069	PF00489	IL6	IL-6; 	Interleukin-6/G-CSF/MGF family	Finn RD	anon	Prosite	Domain	\N	21.40	21.40	22.20	21.60	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.86	0.71	-4.63	10	256	2012-10-02 01:28:15	2003-04-07 12:59:11	12	2	99	27	74	227	0	135.50	31	71.80	CHANGED	I++IlucISAL+KE...hCssaphCcssc-sLAENsLsLPKhtppDGCaQoGFNQ-sCLs+IpoGLhEYQsaLphLpsphcusp.sslcsLQhsspsLlphlpQchcs.t..ssssPsspssLtshhpupspah+csshhLIL+sLccFLphSLRAlR	..................................................h.tt............Ctt.t.C.sp..hlhtppL.slPph.p.tDu.C....ppuh..sp..psCLp+lpsG..Lh.aphhL..c..hlps.p.hts..tt....tp..l..csl.phsspsLhphlpp..chc....p......hh.sPs.hp.sshhsphps..ps.tW.+phsh.hlILpsLpsF...LphuhRsl+..........................	0	3	6	22
+3070	PF01415	IL7		Interleukin 7/9 family	Ponting CP, Schultz J, Bork P	anon	SMART	Family	IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.	21.00	21.00	21.00	21.30	20.40	20.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.74	0.71	-4.49	7	77	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	28	3	23	73	0	111.60	42	85.17	CHANGED	sltG...+cspshtulL.ls..I-cL.cp..sscssCssN.sshhphpl.sDDspcssF....uc+LpQhhphs.pscFslhhp+VppuspsLhNsTs..................hpppKssppppttNsLsFLKpLLpphppshs+lL+G	................pltGpss.phtu.l.h.ls..IspL.pp..t.tssC..sN..shhph.l.sDsspcshF.....tctLpQhhphs.ptcasLhh.+Vppss.hLhNspst.......................hppppshppppphNshsFLKpLLpphppph.+hhht............	0	2	2	2
+3071	PF00048	IL8	il8; 	Small cytokines (intecrine/chemokine), interleukin-8 like	Eddy SR	anon	Overington enriched	Domain	Includes a number of secreted growth factors and interferons  involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.30	0.72	-4.00	181	2117	2009-01-15 18:05:59	2003-04-07 12:59:11	15	8	161	279	731	2035	0	63.80	25	56.48	CHANGED	hus......C.Chph..psphls.hphl...p.saphhssst.Csp.sulIhp.h+......p.s+plCssP....pppWVpch..l..chL	.........................tt.........C.Chph....tpp.ls...hphl.......p..shp.hhssu...tCsp..tlIhp..hK.................p..scplChsP....ptpaVpchl.pt............................	0	45	90	187
+3072	PF01787	Ilar_coat		Ilarvirus coat protein	Bashton M, Bateman A	anon	Pfam-B_1131 (release 4.2)	Family	This family consists of various coat proteins from the ilarviruses part of the Bromoviridae, members include apple mosaic virus and prune dwarf virus. The ilarvirus coat protein is required to initiate replication of the viral genome in host plants [1].  Members of the Bromoviridae have a positive stand ssRNA genome with no DNA stage in there replication.	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.92	0.71	-4.74	20	499	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	29	2	0	481	0	189.10	34	91.67	CHANGED	s....sstpsststssuRppphsspRAsuhRsp.t....ssstsshPl......slssspps.tsphplphPssts......h..sspssophsupssssh.sshshcThlpsI.pl.cssTKlYsllhGFlu.pSDGhhGhl..-uhsssssssPsslsRhtFKKspYpu+phshssGpsls-l.sshslVWphDss....tpsspplplscaWluhSc.PslhPPpsFLVs--	..........................u..stpsttspssst...htttptsspsss.......tss+hsssh........Pss.spss.popWpl+GPNs.s+.....t.a.sspsp.pElos.s.ssspa.hsIsFpohhtplh...spshplaslllphsu.sSsGhhGhV..-sacss...sssuPNsls...R+...GFpKcp.RGhQacsP....sshshsshscshtlVhcacsp....h.suscV...hhpshal.hSt.s.l..PpshLhsp............	0	0	0	0
+3073	PF01450	IlvC		Acetohydroxy acid isomeroreductase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Prodom_2380 (release 99.1)	Family	Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine.	29.10	29.10	29.10	30.20	28.10	29.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.67	0.71	-4.27	19	5123	2012-10-02 19:36:47	2003-04-07 12:59:11	14	7	3940	36	1202	3289	2644	141.90	39	46.51	CHANGED	Fc-EscoDLFGEQsVLCGGlpt......................LlcsG.......................................................................................................................FETLlEAGYp.PEhAYFEslHE.lKLIVDLIactGlttMphslSsTAEaGshspusRlhsptoKttM+clLc-IQsGsFu+chlhpspsup.p..hpthpcp.cpc.IEplGccLRthhshhp	..........................................................................................................FppEscoDLaGEQs...VL.C.G.ulpu.llpsu..................................FE.sLV.Eu.Gat.PEhAYaEsL..H..E...hcLIs-LlhcGGls.p.Mph.sIS.sTA..Ea.G.sYlhu.sclh..tts+.hh...+....phhs-IQsG...p...Fucs.h..l..t..-..t.......p..s..s.psp.....hps.h.Rc.tttpctIEplGtcLRthMs.h.................................	0	361	757	1011
+3074	PF00920	ILVD_EDD		Dehydratase family	Bateman A	anon	Pfam-B_1309 (release 3.0)	Family	\N	18.60	18.60	18.60	21.70	18.50	18.30	hmmbuild  -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.64	0.70	-6.08	89	6864	2009-09-11 11:08:28	2003-04-07 12:59:11	16	13	3924	2	1852	5418	6322	522.70	40	91.02	CHANGED	+PhIGIssoas...........-hsPsphHLpcluctlKpGlppuGGhP.hpasohulsDGIshGptGMchSLhSR-lIAsslEhhlpups.hDuhlhluuCDKssPGhLMuAsRl.slPulhlsGGshhsGph.....tG...........ppls...hpssa-uhGt.ht....tGclscc-............lpplEpsusPus.GuCushhTANTMsslsEALGhuLPGuushPA......sssc+tphucpuGcplhch..l.....c.c.......slp.Pc-IlTccuhcNAlssshAhGGSTNslLHLhAIA+c...AGlp...lsl.-DF-cluccsPhlsslpPu.G.pah.hpDhptAGGlsslh+pLhct.s..h..LctDshTVo......G+TluEplpps...................................hstc..................................VI+PhssPhps..pG.GltlL+GNLAPcGAVlKhuus........chhta...........cGsAhVF-uE--shpAl.tssclc.Gc........VlVlRapGP+GGPGMsE..MLssTuslh.utGlupcVALlTDGRFSGu.o+GhslGHVuPEAus.GGPIAllcsGDhIpl..Dlt..sppLslh.ls-cE.........l....tp.R.+.......ttat.s.......s......sphp......pG.hLttYsphVssAspGA	................................................+PhIulssoas-hlPu..........H.......hH.Lcc..........hu....chl+culcp.A.Guls.hpF.............s...T.lu................l...sDGIu..h.GptGMhaSLsSR-lIAsSlEhhlsuph.hDuhlhlusCDKlsPGhLMAAhRh.sl...............PslFVsGGPMtsGts..........p.h.............................p.t.ht.....hhshh.c.u.h..t.t.h.s....s.G.c..l..o..c..pc.............l.h..ph..E..ps....uCPos.GoCuGM....aTANoMsslsEuLGl.u.LPGsuol.A....................sp.s..p..Rcplh.tpAGcpllchs........c...c.......................sl.h...Pp...cI......lTccAa-NAhslshAhGGSTNslLHLlAhA...pc.........A...G...l.c......h.sh..cDhsc..lS......cc..VPh..LscltPu....G....p.ah..hpDla....p.A.G...GlsullpcLhc..s..G..........L.L.+t.DshTVs........Gp.TL.s-tlpph............c.........................hs...s.tp.....................................................................lI+s..h-..pP..hpp........cG..GLtl.L.p...........GNLA.p.G.uVlKsuuV.s............ph.h..pa......................pGsAhVF-Sp--.shpAI.....s...s....c..l..p..t..G-.........VVVlRYpGPKG..G..PGM..E..MLtsTu..hLh..utGlGcclA.LlTDGRFSGu.opGhulGHloPEA.A.s.G.....G...............s....IAllc-GDhIplDhs....sppl....pl......l....s..-.tE....................Lsp.R.+.................tt.hp..s..................p............p.ht........pshLttYsphsouAspGA.....................................................................	0	509	1129	1530
+3075	PF05046	Img2		Mitochondrial large subunit ribosomal protein (Img2)	Wood V	anon	Pfam-B_17929 (release 7.6)	Domain	This family of proteins have been identified as part of the mitochondrial large ribosomal subunit in yeast [1].	27.30	27.30	28.30	27.90	26.90	27.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.91	0.72	-3.75	22	279	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	228	0	205	270	3	82.20	32	50.39	CHANGED	shsYaVpR..opsspLPVYhch+ttGs+hhTt.........IRKlpGDl.sLcpDLpphLs...t........shpVs............................chsGplhlKGthhpclccaL.ppsF	.................hsYaVcR......opsp.plPVYhch+.......p.......tGs.+phTh.........lRKl-GDl....htLppDLpphLt...t............tspls..................................phsupltlK.G...h.hpplcpaLhpttF.........................................	0	81	116	170
+3076	PF04156	IncA		IncA protein	Bateman A	anon	Pfam-B_2718 (release 7.3)	Family	Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions [1]. This family probably includes members of the wider Inc family rather than just IncA.	50.00	50.00	50.20	50.10	49.90	49.90	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.36	0.71	-4.70	54	286	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	42	0	56	201	0	185.00	17	49.97	CHANGED	shptplhslshlllull.llssGlss.Lshhh...hushhsshluhshlAlu..hlLlshulhhhhtpp.ht.hpttp...........................................................chtphppplsplp...cclpp..hppphtphppplpphppshpttp...........p.hpphppclpshppshpphtpchpclh...................t.ht.....htt......t..tthtphhtp.pplhpp...........h	............s.ht.hlhslhhhlhull.llssGlss.Lshhh...husslshhlslshlAls..slllusulhhlhpppphthhpstth...................................................plpphpptlspLp...p-hsp..hppphtphppplpthppsh.ttp...........p.hpshtpplcshppphpphtpchpclh............................tthpphhpphtth..........t.ptlt..htp..t.hp..h........................................................................................................................................	0	5	6	55
+3077	PF02387	IncFII_repA		IncFII RepA protein family	Bateman A, Mian N	anon	Pfam-B_1209 (release 5.2)	Family	This protein is plasmid encoded and found to be essential for plasmid replication [1].	22.90	22.90	22.90	23.10	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.85	0.70	-5.24	22	635	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	342	0	25	477	1	239.80	41	90.66	CHANGED	M...........s+ppYVpNspPhFs.P+psK+pssFI.phhMcpA....uchDlA+p.hphphhshs.hTh..h.................RpRphNtHRApAhcAll.AMhaHashhoshVpsSIcpLuDECGLoThSpuGNpSITRASRhlspFhEshGhIpsc+haD.hlusYIPKhIhlTPhFF.LhslSptpltsApppplpW.Npphpcctht.lohsEhhhpuhc..hpphhphptphh.h.hp+t.A++hhph....sEcsh+pcIlptLl+pYotsELsphG.puLK+cls.cY..L++ltpp.	...........................................................tph..............P.a..stp.t....th....h...thhht+s.....schDhsh..p.....hahp...h....s.........................hR+Rh.sshRpRAlDALl.uLsaahD..shus.....pVptSlopLAhE.CG..Lu..T..cS...u............uG.......p......l......S..I......T..R.Ao..RuL.pal..t..chGl..I...........o....h.pT..p...aD...hush..lPpcIhhTPAhFthL..sVopstltst..p....c..pRlchp.....sppp....pcpth......ss.Lth.D.E......lh....A+s..hR......ahhpRhpshppch+u+.uh+.....R.tR.ARR.sph....pcpchlphltctLp+clstschht.st-slKRpl.hc...........cpphhht.......................................................	0	6	11	18
+3078	PF02974	Inh		Protease inhibitor Inh	Griffiths-Jones SR	anon	Structural domain	Domain	The Inh inhibitor is secreted into the periplasm where its presumed physiological function is to protect periplasmic proteins against the action of secreted proteases [1]. A range of proteases including A, B and C from E. chrysanthemi, alkaline protease from Pseudomonas aeruginosa and the 50 kDa protease from Serratia marcescens are inhibited.	25.00	25.00	25.10	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.29	0.72	-4.42	27	259	2012-10-01 18:54:33	2003-04-07 12:59:11	9	4	230	3	85	217	6	98.80	31	59.58	CHANGED	AoSlhl.ssupluGpWpls...............tsspsCcltLspsph.ts...thuGshsCssph.LuphsssWpsoPcslsLhstsGsslshhs+pscspapuphssG.tslsLpR	..........ssoh...ssusluGpWplu...............tuspsCcltLspsphspG.........hhuGshsCssp...Lsphsu.Wt.s.s.s..ct.lsLh-ssGsslupLhpsupupac..up.ps.uG.pslsLpR....................	0	13	34	54
+3079	PF00876	Innexin	Ogre; 	Innexin	Bateman A	anon	Pfam-B_779 (release 3.0)	Family	This family includes the drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions [1]. This family has been named the Innexins [2].	21.80	21.80	21.90	22.10	21.40	21.70	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.50	0.70	-5.34	99	863	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	123	0	560	840	1	283.30	22	76.49	CHANGED	Dshs.RLpaphTshlLlshul...llos+QY.h....GcP...IpCh...ssphs....ppahssYC..alpsTahl......................................................s...hspph.....................s........sthp.c...thchhsYY...............QW.....VshlLhlQAlhFYlPphlW+.....shpGhplctlspth...................ssshhsp.........-ppcpp...................hchlspah.pptlptpp..th.....................................................shhYhhsclL.llNllsQlahhstF.Lut..............................sat....haGhpllt.h........hps....pphppsh..hFP+lThCsap.....phG.........s.hpp.ass.CVLslNhhNEK.......IalFLWFWhhhlulloshsllahlhplhhs.....phhhphLch.......psphts.....................................................................hpchtt..chLphsshFlLphlspNhssllhp-l...lppLhppapp.p	....................................................................................s.h.+lphhhTshl.......lhhhsh...........llssppa.h...................G.pP......IpCh......s.sphs.............tpahpsYC......WhpsT.ahl................................................................t..pth...........s.......................t.t..........t.htYY...................QW.....lsa...hLhhpAhhhYlPphhW+..........hp.uhp.lphlhpth...........................ppsh..t.................ptpppp........................hphlhphh..p..h.p.pp.h.......................................................................................................................shhYhhhchL.hhs......hlhphhhhsha.ls..t..............................................t.......au....thh.......h...........................h..........hFP+.hsh.Cph......hu..........s..p..hsh.Cll.hNhhsEK..............................lahhla....hWhhhl.hhshh.hh.hhh....h..........hh..hh...........................................................................................................................th.....t.ht.sshhhh..ht.p.s...h.ph...h.th.......t...............................................................................................................................................................................	0	230	281	485
+3080	PF01658	Inos-1-P_synth		Myo-inositol-1-phosphate synthase	Bashton M, Bateman A	anon	Pfam-B_959 (release 4.1)	Family	This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated  to inositol [1]. Inositol phosphates play an important role in  signal transduction.	20.00	20.00	20.00	24.60	19.30	18.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.15	0.71	-4.24	60	1141	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	916	36	533	1086	280	110.30	40	26.16	CHANGED	GtThh+ssLuphhtsRGl+lpshhphNhhGNsDuhsLss.pphcSKchSKosslsshls.......h................................................pts.HhsslcYlPhlGDpKhAasclcsptFhGsshplplphpspDS	............................................GtThh+pVLschhhsRGl+lsphhphNhhGNpDhhNhtp.pphcS.Kc.ISKopsVs..shls....tp..Lh...............................................tpcssHls..s.c.YVPals.DpKhAhschpuchFhG..s..slph+hpspDS.............	1	186	341	459
+3081	PF00459	Inositol_P	inositol_P; 	Inositol monophosphatase family	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.84	0.70	-5.10	59	10135	2012-10-02 15:53:20	2003-04-07 12:59:11	20	42	4250	79	3140	7691	7848	256.80	24	93.87	CHANGED	phpplhphs.......hphsp.tuuplltptht......pphshphcs.........sssD...h..VTtsDptsEphlhpt....lppth....Pscsh..luEE.shstss..........................h........sss.hsWllDPIDGTpsFlcGh..............shaulslulhh......ptpPlhGllhsP.......h................hs...p...hapuhpG........p.Gu..hh...su...............l..plpsss........hspsh..hhsththp.....pttphsp...h..htth.thhstt...............h..R.th...Guush..clshlApGpsD..sahch..s......hp.WDhAAGthllcEAG..............Ghls.chsGs........hsh..hs.t..thlsus...........tth...hhpthp.phht	.........................................................................................................................h........hhphsp.pAuphlh.phhp...........pthphphcp....................................ss.s...........VTp.sDp.ts..cphlhpt.....Lppt...h..............P..s...t..s..l........lu.EE..s..stt.ts..................................................................................tpp.th.hW..llDPlD..GTpsF.lc.sh.............................................sp.a..ulsIAlhp.................cG.....p.....s...h.h....G....l....lasP......h...................................................ts....c.......ha.h...A..t.cG..............t..G...A....h..h....ss...........................p...l...psppsp...................................hp.ts.h....l...h.s.......h..s..h..p...............t..p.t..t...h.t.p............h.....h.t..th..h..t.thptt...................................................h..R..th...G.uu..ul...ch.s.h.V......A......p.........Gp.........h.D....s.a..hch.s........................hp.WD...h...A...AGthl.lpc........AG..................G..hl.s...s.h.pGp.....................sh.h.......tp....t.....thhhss.........................hh..........................................................................................................................................................	0	961	1869	2579
+3082	PF03488	Ins_beta	Ins_beta_nem; 	Nematode insulin-related peptide beta type	Griffiths-Jones SR	anon	PRODOM	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.97	0.72	-4.16	11	116	2012-10-01 19:54:34	2003-04-07 12:59:11	9	2	6	1	114	148	0	47.10	30	45.29	CHANGED	hRuCGR+LhphVhslC.G-.CsspsshDIuspCCpsp..CTc-aI+psCCP	........+tCG.p+lhp...hlhplC..ut.....C.s.....s...psshcl..u.stCCspt....socp.lpptCCP.......	0	32	37	114
+3083	PF03811	Zn_Tnp_IS1	Ins_element1; HTH_Tnp_IS1;	InsA N-terminal domain	Griffiths-Jones SR, Bateman A	anon	PRODOM	Domain	This appears to be a short zinc binding domain found in IS1 InsA family protein. It is found at the N-terminus of the protein and may be a DNA-binding domain.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  --amino -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.90	0.72	-4.46	4	1346	2012-10-03 10:42:43	2003-04-07 12:59:11	8	14	477	0	86	743	12	33.10	58	28.45	CHANGED	MAoVsl+CPpCpus-.VhRHGpussGHpRaRCppC+	........MAolslpCPpC.s...........usc.VVRNGKSTAGH.QRYL.CScCR.....	0	15	37	72
+3084	PF00049	Insulin	ins; 	Insulin/IGF/Relaxin family	Eddy SR	anon	Overington enriched	Domain	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.68	0.72	-3.19	28	1447	2012-10-01 19:54:34	2003-04-07 12:59:11	13	6	340	923	373	1711	0	62.30	31	56.65	CHANGED	ppLCGscLV-sLh.hVC...G-......R.GFaY..P...hsh.......ht....................................................................................h....ptt+......tKRG..IV-pCChpsColtpLpsYC	.......................................................................................plCGtcLscsl..hlC...st...............h...th..................................................................................................................................................................................ppG.....l..scpCC.hp.sCsht..L.t..hC.......................................................................................................................	0	102	130	226
+3085	PF00552	IN_DBD_C	integrase; Integrase;	Integrase DNA binding domain	Bateman A	anon	SCOP	Domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain.  The central domain is the catalytic domain Pfam:PF00665. This domain is the carboxyl terminal domain that is a non-specific DNA binding domain [1].	20.70	20.70	20.70	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.65	0.72	-4.52	37	14492	2009-01-15 18:05:59	2003-04-07 12:59:11	16	61	191	15	23	12714	0	49.90	85	8.72	CHANGED	hppphsYa+...cspstpW+GPsplLhcGcGAlllpspppt.hhhlPc......RcsKhl.s	..........I.QNFRVYYR...DSRDPlWKGPAKLLWKGEGAVVIQ.DNSD..IKVVPR......RKAKIIRD........	0	9	11	16
+3086	PF02920	Integrase_DNA	integrase_DNA; 	DNA binding domain of tn916 integrase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.80	20.80	20.80	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.20	0.72	-4.56	4	459	2012-10-03 08:51:45	2003-04-07 12:59:11	10	6	296	5	41	279	13	64.40	54	14.30	CHANGED	EKc+cs+tchl+suEsptK-hRYhhKYl-phtcspFsYSWKLlsTctssAtKp-sluLR.K.tEIpK	....................EKRRDsKsRlL+sGES..QR.p.DGRYLYKYlDsaGcspaVYSWKLss.TDcsPAGKR-slSLREK.sclp+....................	1	8	15	21
+3087	PF00357	Integrin_alpha	integrin_A; 	Integrin alpha cytoplasmic region	Bateman A, Finn RD	anon	Prosite	Family	This family contains the short intracellular region of integrin alpha chains.	20.20	10.00	20.20	10.10	20.10	9.90	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.96	0.74	-6.32	0.74	-3.75	27	407	2009-01-15 18:05:59	2003-04-07 12:59:11	15	17	77	12	158	412	0	14.90	53	1.49	CHANGED	KhGFFKRph.th.pt	KsGFFKRsh.sh.-.....	0	16	23	59
+3088	PF00362	Integrin_beta	integrin_B; 	Integrin, beta chain	Finn RD	anon	Prosite	Family	Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1].  The sequences repeats have been trimmed due to an overlap with EGF.	25.70	25.70	26.20	28.00	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.47	0.70	-5.59	48	945	2009-09-12 08:02:03	2003-04-07 12:59:11	13	57	153	59	425	786	1	347.30	38	48.53	CHANGED	oCp-CIpsuP...pCAWCsp....................................sF.t....sssRCDshp...pL....hppG....CstppIpsPp..uphpl..tcspsLosttt...........................................t.ph.sQlpPQclpLpLRPGp...................................stpFplph+pscsYPVDLYYLMDLShSMcDDLpsl+sLGspLucchp.plTsNaRlGFGSFVDKslhPalsTsPpc.lpsPC....t.t.sCtssFGa+plLoLTccsspFsppVpcQplSGNlDuPEGGFDAlMQsAVC............................pccIGWR..spup+LLVasTDusaHhAGDGK..LuGIlpPNDGpCHLcsss.........hYotSsth....DYPSluQlscKLp-ssIpsIFA......................................VTpphhs.........lY............cpLsphI.s..soslGhLusDSuNVlpLIpcAYpclsScVplp.pshP-s.lslsasupCts.spth.s.....ppCsslplG-p..................VsFsVplsspc.......Cspctt...pshpI+P.....lGFs-p...LpVplphhCc.C	............................................oCtpCl...ts...tCuWCtp.......................................sa............s.R.Cs.....t..pL..h..tpG........C..p.l....P.t..u.p.hph......psps..lspt............................................................................t.sQlpPQpl..tl.....pLR.s...G..p......................................tphplph+....p...sccYPlDLYYLMDLSh.SMpDDLpplcpL....Gs..p.L...hpthp.pl...........T......p....s...hR.lGFGo.FVDKsl.P....ah.pht...Ptc.lpsPC.......t......pC.ssFu....a+plLsLT..s.psppFpptVt.p..p...p.lSu.N....lDsPEGGh.DAlhQssVC........................................................t..pp..IGW..R.....p...sp+LLVFsTDs.shHhA..hD..G+..Lu....GIl.....P.NDGp.CHLpss.................Y.sh.S..p.h..........DYPSluplsppLsp.pNI..IFA........................................V.Tp..p....h.....................................hY.............pphpphl...P......to.s..lG...L...p.p.cS..sN....llp...L...lh.pAYp..plpS.......pV.l.p............p.......scs.....lp...l.pa.p..u.h..C.s....s....h..t......tpCpslplGpp..................lpFplplp..h..p.p.........C...t.p..t......pphhl+s.....hGh.p-t...lpltl..p..h.....CpC..............................................................	0	104	134	265
+3089	PF00143	Interferon	interferon; 	Interferon alpha/beta domain	Sonnhammer ELL	anon	Prosite	Domain	\N	25.00	25.00	25.80	25.10	23.90	23.60	hmmbuild  --amino -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.95	0.71	-4.37	15	1000	2012-10-02 01:28:15	2003-04-07 12:59:11	14	1	135	18	321	1009	0	150.70	39	85.89	CHANGED	LPpsasLss+csLpLLtQMsRlSsh.CLcDRpDFsFPpEhhcupQhQKAQAhsVL+EhLQpIFslFpo-pSS.AuWNpTLL-pLpssLaQQLscLcsCLtppht.pEsshsppssh...Lsl++YFpRIplYLcEKKYSsCAWEVVRsEIhRulShS.sNLptRLRp	................................................ppthhspcsLp..LLs.pMp+.l...s..s..hpC..L.p.-..RpD..F.sFP.p...Ehh.p.u.s...Q.h.Q..K..s.Q.A...l.sl.lHEhlQQhFpLF....s..o.ctSu..AuWspoL...L-phhssLp.QQLpcL-.sClhpphs..pc.s.s..l..hpp.ssh...............Lsl++YF.p+I.s.h.Y.LpEKcYSsCAWElVRsElhRsh.....spL.tthp...............	1	17	20	70
+3090	PF03487	IL13	Interleukin_13; 	Interleukin-13	Griffiths-Jones SR	anon	PRODOM	Family	\N	25.00	25.00	46.40	46.40	23.60	19.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.00	0.72	-4.25	4	47	2012-10-02 01:28:15	2003-04-07 12:59:11	8	1	36	11	14	53	0	42.00	77	32.90	CHANGED	MALhLTsVIALsCLGGLASPuPVPsSs....sLKELIEELVNITQNQ	..MALhLTsVIALTCLGGLASPuPVPs.So....ALKELIEELVNITQNQ.	0	1	1	1
+3091	PF01348	Intron_maturas2		Type II intron maturase	Bateman A	anon	Pfam-B_105 (release 3.0)	Family	Group II introns use intron-encoded reverse transcriptase, maturase and DNA endonuclease activities for site-specific insertion into DNA [2].  Although this type of intron is self splicing in vitro they require a maturase protein for splicing in vivo. It has been shown that a specific region of the aI2 intron is needed for the maturase function [1]. This region was found to be conserved in group II introns and called domain X [3].	20.80	11.50	20.80	12.00	20.70	11.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.98	0.71	-4.23	25	36524	2012-10-02 14:46:49	2003-04-07 12:59:11	16	20	25025	0	102	35521	17	102.30	63	26.36	CHANGED	ppclphhsPlpplltpLscpsahstp........G+PhuhsphssLsDpsIls+aspIhRulhsYYShusN+ppLh.hlpYILRhSCs+TLApKaKs.Tlpphhp+aG................ssLh.pphhsppcph.............shthpphphshpp.......hhschhhlshhp	...........................................h.KKhDTlVPIIPLIGS.L...u.....K.AK..FCNlh..........GHPIS..K..P.l.W.s.D.L.SDS..DII.DRFsRICRNLSHYa.S..G.SS.K.KpsLY...+lKYIl.......................................................................................................................................................................................................................................	1	28	68	90
+3093	PF03519	Invas_SpaK		Invasion protein B family	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	26.90	26.40	24.20	17.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.67	0.72	-4.14	7	181	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	173	8	14	65	0	77.60	50	58.83	CHANGED	GCsssllusLDsHSTIsLcL.p-hPsIpIuhpsDD...lhlWusls-hppshlptpu.plLt.lhpss..sathGt.h.ltcpss	.........GCsPSLIGslDSHSTIsL-L.aulPoIsISlcDDD...VWIWApL....GAsShVlLQQpAYEILhsIME.uC..pFupGsQlLLtcps.......................	0	3	7	9
+3096	PF04741	InvH		InvH outer membrane lipoprotein	Mifsud W	anon	Pfam-B_3503 (release 7.5)	Family	This family represents the Salmonella outer membrane lipoprotein InvH. The molecular function of this protein is unknown, but it is required for the localisation to outer membrane of InvG, which is involved in a type III secretion apparatus mediating host cell invasion [1,2].	25.00	25.00	25.40	25.20	22.80	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.02	0.71	-4.35	3	211	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	181	0	2	80	0	116.60	64	95.63	CHANGED	MKKFYSCLPVFLLIGCAQVPsPSSGSKPVQQP-AQKEQQANAcSIDECMSLPYVPSDLAKNKTLSNQNADNSASKNNTISSSIFCEKYKQTKEQAFTFFQEHPQYMRSKEDEEQLMTEFKKVLLESGSKNLSIYQTLLoAHKRLQAL	...........................MpKhYSCLPhFhLlGCAQss...ShSKPVQQssAQpEQ.AsAsSIDEC.SLPYVPsDLAKNKoLSNpsADNSASKNssISS..SlFsEKY+QTKEQAhsFFQEHPQYMRSKEDEEQLMTEFKKVLLEPGSKNLSIYQTLLsAH-RLQAL.....	0	0	0	1
+3097	PF00904	Involucrin		Involucrin repeat	Bateman A	anon	Pfam-B_1158 (release 3.0)	Repeat	\N	30.00	0.10	30.90	0.30	22.00	-0.10	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.55	0.75	-5.76	0.75	-2.71	129	691	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	12	0	40	721	0	10.00	64	70.08	CHANGED	lEQQEGQLct	.LEQQEGQLch.	0	40	40	40
+3098	PF02121	IP_trans		Phosphatidylinositol transfer protein	Mian N, Bateman A	anon	IPR001666	Family	Along with the structurally unrelated Sec14p family (found in Pfam:PF00650), this family can bind/exchange one molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC) and thus aids their transfer between different membrane compartments. There are three sub-families - all share an N-terminal PITP-like domain, whose sequence is highly conserved. It is described as consisting of three regions. The N-terminal region is thought to bind the lipid and contains two helices and an eight-stranded, mostly antiparallel beta-sheet. An intervening loop region, which is thought to play a role in protein-protein interactions, separates this from the C-terminal region, which exhibits the greatest sequence variation and may be involved in membrane binding. PITP alpha (Swiss:Q00169) has a 16-fold greater affinity for PI than PC. Together with PITP beta (Swiss:P48739), it is expressed ubiquitously in all tissues [1].	21.30	21.30	21.60	22.40	18.60	19.20	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.57	0.70	-5.20	4	692	2012-10-02 19:24:03	2003-04-07 12:59:11	13	19	134	7	422	566	0	221.10	45	46.39	CHANGED	hLIKEYRllLPhSV-EYQVuQLY.lActS+pEouG.GpGVElLhNEPYccs.GtpGQYTHKIYHltS+lPualRhLhPcuALslcEcAWNAYPYsRThhTs.ah.EcF.IcIETaahPDhGpQ-NVapLssssh+ph.lshIDIs.RsQVhsuDYKAEEDPthF+SlKTGRGPLussWtcEh...spstcpP......hMCAYKLspVcF+aWGhQsKlEpFIHc.t.RRlhhphHRQhaCW.DcWh-LTM-DIRchE-ETp+tL	...........................................................................h+Ea.Rl..hP.ho.....V.-E..YpluQLY.lu.ctS+pp............o.........s.........G.............G.pG.....V......E.....llp...N.cPa........p..........c.....s.......................s..............t..............p....GQYTcKlYHlt......S+lPuah+hlh....PcsuLhlcEcAWNAYPYs+..T......h.............h............T.........s......s.ah..-cF.IcIET.hap...s.D..h.G..pp..-N.V......a.sLss.....pp.hpph.pl..shIDIs..pct.l...s.t-YK...t...-..EDPphFp.S........KT.........sRGPL.s..s.Whcph..............pP............................hMCuYKLlplcF+.aWG.h.Q.s+lEpFIp.c..t.........+clhhphHR.....QhasWh.......Dc......W......h.......sLTM-DIRchEccsp..................................................	0	135	169	310
+3099	PF03278	IpaB_EvcA		IpaB/EvcA family	Mifsud W, Bateman A	anon	Pfam-B_4003 (release 6.5)	Family	This family includes IpaB, which is an invasion plasmid antigen from  Shigella [1], as well as EvcA from E. coli Swiss:Q9ZNF1. Members of this family seem to be involved in pathogenicity of some enterobacteria. However the exact function of this component is not clear.	29.90	29.90	35.50	35.00	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.89	0.71	-4.99	9	303	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	125	10	3	134	0	135.40	47	82.57	CHANGED	Muppo.lhlshsKlssplLpsVu+Qo.spDlpsWhppE+psYsSRslNpsIDcaChpNNssIosEs+p+lFphVEpca.plsLDhpuAQSSIsHh....ltuNuhFsKKlDp.C.cGhshts+NsTpsplhNhlucpha-Kphs.....scI-lhp.psp	......................p..hhhshsKhssplLpsVu+Qo...stDhppWhppEphsY.SRslNpp....ID....sYChp..........p...Nu...hI...........SpEp+p+lFphVp.....p.....t......h...p.sLDhp...uAQSSIsHh....l.uNt.FsKKhDt..C...cGhs.....s+tsTpsplhs.lucchap+phs.....s-Ichlp.+sp................	0	0	0	3
+3100	PF04979	IPP-2		Protein phosphatase inhibitor 2 (IPP-2)	Moxon SJ	anon	Pfam-B_5306 (release 7.6)	Family	Protein phosphotase inhibitor 2 (IPP-2) is a phosphoprotein conserved among all eukaryotes, and it appears in both the nucleus and cytoplasm of tissue culture cells[1].	20.90	20.90	20.90	20.90	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.02	0.71	-3.90	20	478	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	281	4	294	440	0	115.20	26	55.30	CHANGED	+KS.pKWDEhNI..LATaHPu-KDYGhMKlDEPpTPYp......pspsshs-s-sscsls....s-sLucKL..sAucupssshthc.-ppssp..p--p-l..o.Eccp++cpFEp+RKhHYsEhhslKLARpLI..scEhps-s---pp	..........................................................+WDEhNl..h.o.c...tp..ct..shMKI-EP..pTPYp.......h...........tsts.......t.....................t......p.........pc.s..pp.th.s..........................sptl.s.pph..........ts.ps...t..p..............p.h..........t.....t...ppppt..........tpppph.......p.pp.p....t+ptpFc.tRKhHY.s.Eh....h.p.........p.ph....tp...........tt.................................................	1	89	146	221
+3101	PF01715	IPPT		IPP transferase	Bashton M, Bateman A	anon	Pfam-B_1875 (release 4.1)	Family	This is a family of IPP transferases EC:2.5.1.8 also known as  tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs  at A(37) to give isopentenyl A(37) [2].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.37	12	5290	2012-10-05 12:31:08	2003-04-07 12:59:11	12	20	4605	26	1405	4112	3280	236.80	32	78.09	CHANGED	hplYKshDIGTAKPohp-hpslPH+LlDllDsscsaosupapcpAhptl....p-IptcG+lPllVGGThLYhpuLlcGls.hPts..-sslRtclcpphtppG.shLatpLsphDPttAstIpPsDspRlhRALEVahhTG+shophtpp............tps..ashl.luls.hc+c.LapRIspRhcpMlcsGhlpEV+tLhsps.......hppshsuh+ulGYpphhsaLpG....chs.LsEhhpphhpsTRphAKRQhTWhRp..t.lpWlDst	...............................QlY+s.h.DIGTAKs....o..........c........E...h........t...s.....lP..H+LlD.....lh.......-.s.....s..p................s..........a..Ssu..cFppcAht...tl...............p.c.I...t...s.c.....G...+.l...P.l.l.V.GGTsLYhpuL...l................ps.....h.........s.............h....s.ts............s..........p...l..........R.........t............p............h..........c.....p...................p...........h......t............p............G......................p..t.......L...app....L...t....p...l...D..P....s.A.t....c.I..c...s...s......s.......pRlhRA..L..El...h.h.h.....o...G..p.s..hophhpp......................................t...t....h.......a....p....s...h....h...h.uls....hs..R.phLa.pR...IspRhc.tMl..p.......p...G..h.lc..E....l...ctL.hpps.........................t....s.....h.s..u..h.....pul.GY+phh.s..Yl..pG............................chs....h--......h....h....p...ph....hpsTRphAKRQ...hTWhR.p....t....hpah...t.....................................................................	0	467	901	1191
+3102	PF01745	IPT		Isopentenyl transferase	Bashton M, Bateman A	anon	Pfam-B_2229 (release 4.1)	Family	Isopentenyl transferase / dimethylallyl transferase synthesises isopentenyladensosine 5'-monophosphate, a cytokinin that induces shoot formation on host plants  infected with the Ti plasmid [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.55	0.70	-5.19	7	88	2012-10-05 12:31:08	2003-04-07 12:59:11	11	5	64	7	18	3011	1753	163.70	35	80.48	CHANGED	hplaLIaGsTsTGKTuhultLAppTGhPVlsLDRlQCh.plusGSGRPhssELpuTcRlYLs.sRslscGlIsAccApcpLhtcVppa.s.csulILEGGSISLlppMups.aWpssF.WplpRhcLssc-sFhspAKpRlppMLpspsstsSlLsELsphWtpsst+shLEsIDGYRhhlcaApppplsh-pLhslst..chhppLlpuIApEYhpHAhhQEp-FPth.....thttu.	..........lhlIhGPTsoGKTshAlt..L.....A....c.....t.....h.......u.....h.....s....l..IulDplQ.sh..plssG..Su.R.Pp.s.s.E.L.p.u.s.p......R........aLt....pp.l........p....G......h.ss..t..p..h.....t...h..hh.....l............t....tt.................h......llEGGS....h...SLh.th.........p.................................h.h.....h...........h.....t.....t..a........h.t...Rhtphh.......t..uhhtEl..hh...t.h...httl....sh.......p..h.aht..th..t.........t...................................t...................................................................................................................................	0	5	11	16
+3104	PF00605	IRF		Interferon regulatory factor transcription factor	Bateman A	anon	[1]	Domain	This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.	21.00	21.00	21.10	21.80	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.71	0.72	-4.28	26	872	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	101	29	310	642	0	105.30	43	28.65	CHANGED	RhRL+PWLltplsSGpasGLpWlsp-+phFpIPWKHAuR+shs...-cDusIFKAWAltpG+aptG.-cs.............DPssWKsshRCALNpos-Fp.lhDpop.csspP.aKVYclh...s..t	.........................+h+sWLltQ.lsSspa.PGL.tWls.c.-.+phFpIPWKHAu+pshs...-cDuslFKAWAltp.G.Kapt..G...D.cs...........DPssWKsphRCAL.Np.....s..-Fc.lh.Dpop....c..sspP..aKVYchlst.....................................	0	43	68	158
+3105	PF04120	Iron_permease	iron_permease; 	Low affinity iron permease 	Wood V, Finn RD	anon	Pfam-B_71435 (release 7.3);	Family	\N	25.00	25.00	25.60	25.30	22.40	24.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.54	0.71	-4.57	19	374	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	264	0	195	387	17	117.30	31	64.84	CHANGED	Fs+hAstsuphsGpPhsFllAlhlVllWuloGPlFcaSDTWQLVINTGTTII.TFLMVFLIQNoQNRDss......AlQlKLDELItusptApNsh..........lslEcLsEcELcplcptapchuctsppt.thsttpptpsttstp	................................................Fp+huphhsphsGpshsFlhulhlllsWssoG.P.hapaS-TWQLlINTuTTIl.TFLMVFLlQssQNR...Dst..............AlphKLcELltshp....tApsth..........ls...lEphp.tplpthtt.h.t.t.....................ptt.............................................	0	38	103	150
+3106	PF02060	ISK_Channel		Slow voltage-gated potassium channel	Mian N, Bateman A	anon	IPR000369	Family	\N	20.60	20.60	20.60	20.60	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.79	0.71	-4.56	3	180	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	45	1	100	159	0	96.40	30	75.87	CHANGED	MILPNoTAVhPFLT+LWQETAcQGGNsSG.LARRSPLuDDGKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKDKAYFQARVLESaRuCYVlENQLAVEQPsTHLPELKPSs	.....................................................................................................ttst..p...h.lYlLhVhuhFuhhlluIhLuYh+SK+hE+ps....D.PaplYI.cp-...Wtpt.......................................h..........................	0	4	10	31
+3107	PF00180	Iso_dh	isodh; 	Isocitrate/isopropylmalate dehydrogenase	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.21	0.70	-5.50	23	12354	2012-10-02 21:08:39	2003-04-07 12:59:11	15	30	5707	258	3358	9844	7894	320.30	29	93.82	CHANGED	pIslLPGDGIGPElhpsAl+VLculsppts...hchpacpthlGGsAIDttG..pPLP-ETlcss+cu.-AlLhGAlGGPcW......t.ssphRPEp.GLLsLRKphs.LaANLRPspha..tLtstSPlKp-hscs.lDhllVRELTGGlYFGp.pttps....................st....phuhsTphYocpE.l-RIsRhAFchAtp+.....+t+VsSlDKANVLcsSc....lWRchsp-ltp..............................EaP-lpLpHhllDssuMpLl+sP.ppFD..VllTsNlFGDILSDtAShlsGS.LGhLPSASLus.......pshulaEPlHGSAPDIAGKsh......ANPlAsILSAAMMLRauhshpcpA......stlEsAVppsLpp......GhhTsDLusts........t.huTs-hs-tl	................................................................................................................lshl.GDGIGsE...lh..ts.hc.llcshh..h...................hpl..php......p.h...h.G....t...t...s..h.c...t.p.u...........p.ls..t.....-s.hpshcc.h..ss...sl.........h..Guls.s.Pp...........................s.th+...s....p....l...lt..lRc..........p.h....s.....hasN...l..........RPs......p..ha.............t.s......ssl+..............s.....t.......t...hD.hll.s.REsot.s..Yt..Ghphthss.....................................................................t........tt.suhsh..phh.o.c.pt...hcRls+hA...FchAhp+.....................+.p.......p.ls.hlc.K.uN.lhchsc....sha.+chsp..-.l.uc......................................................................ch..s......c......l..h..hc.chll....Dshsh...ph.l..p.p.P..tpaD..Vlss.Nl...GD.........llSD.....suhh.s......G.u....lG.hhP...uusls.....................pth..uhaE..s.........s...HG.............o...A..P...c..h.....s.Gps..h..........................sNPhu..Ih....ohshh...L.....c......a.............h.......s.......h...t.......p...t.....A..................ptlpp.u...lt.t.s.ltp......t.h.h.Th.Dhtt.h................tspphhp........................................................	1	1065	2017	2773
+3109	PF04279	IspA		Intracellular septation protein A 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	24.00	24.00	24.00	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.17	0.71	-4.30	129	1696	2009-09-11 22:50:41	2003-04-07 12:59:11	10	2	1533	0	344	990	1626	176.80	39	93.65	CHANGED	M.Khll-hhPlllFFlsYp................hts.............................IhhATushlsAollplshhahhtp.+lspMpllohsllllFGuLTlhhpD-pFIKhKPTllYhlFAssLhsuhhh...t+sllcthh..........sptlp.L....scpsWp+LshtWshFFhhhullNhh......................................V........sh....hop-...........hWVsFKlFGhhulsllFhlsQuhhlh+ah.cp	.......................................................MK.hlDalPLllFFsh.YK........................h.h.s.............................IasATushIlATslt.l.h.h.sa.l...p.a.+..Kl-+MtllohllVlVFGGLTLhhHs-pFIKWKsTll..YsLFAssLLlSphh...p..K..sLIp...p...hL..................G.c..pls....L.........P........p...t.......l...W..............s+LN..huWulFFlhhul...h...Nla..........................................l.......ua..h.....h.sps..............hWVs.F.K.lF.GlhulTll.Fsllpulalh+Hh.p.c....................................................	0	85	177	257
+3110	PF01128	IspD	UPF0007;	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	Finn RD, Bateman A, Eberhardt R	anon	Prosite	Family	Members of this family are enzymes which catalyse the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from cytidine triphosphate and 2-C-methyl-D-erythritol 4-phosphate (MEP) [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.35	0.70	-4.83	6	4492	2012-10-03 05:28:31	2003-04-07 12:59:11	14	13	3924	49	957	7221	4670	220.50	32	84.34	CHANGED	lhsllPAAGpGcRMtsGpPKtalsLtGpslLp+TVcuhLup.tlc+IllslsssDhsthppLLss.....plpLVsGGssRs-SVhsGLpAlssss..paVLVHDuARPhltpsslscllAtt-p.psGuIhAlPVpDTIKRs-.sG..hlscT.DRsGLWtAQTPQuFshsLLhcuascu...ppGuphTDDASllEps.GhpVplVsGcssNlKlTpP.DLAlAEhILpp	...................................................sll.AAGhG..p.R.........M.......s............s.................s.........h......P..............KQ...aL...p.l.......s..s........+.....s...ll...h.+...ol.c...s...h..........h....t....p..........s......t.....l.......p..c......l..l....l..s...l...s.....s....s....p...........s....h......h....p....p.....l..h.tp........................ptp.l..p...l...l......p........G.....G....s....p....R.....t.......-......S....V.h...s...u...L..........p..........t.........l.............s........s........p..........t.............s...........h.............V....L.l...H.D.....u.ARPhls...tch...lp.c..........l.l.p.....t....s.......p.........p.............................t..s.....u....s..l.............s........u..l..P............l...t..D.............T.......l....K......p...s......p.............t.s.................hl.......s........p.......T.s.....s........R........s.......p.......L........a......t.......u....Q.......T.....P........Q...........s....F..p...h..p.....h...............Lpc...u...a....p....ps.....................p..p....t....h........p.......h...T...D..-...u...u.....h...........l.E......hh.....G...h....p.......l..t..l..V..p..G..c..h..p..N..l.K....lTpPpDLt.lAchhlt.t..................................................................................................................................................................................	0	339	640	817
+3111	PF01695	IstB_IS21	IstB;	IstB-like ATP binding protein	Bateman A	anon	Pfam-B_982 (release 4.1)	Family	This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences [1].  The function of this protein is unknown, but it may perform a transposase function [2].	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.91	0.71	-4.86	17	7213	2012-10-05 12:31:08	2003-04-07 12:59:11	12	34	2932	5	1265	9058	3056	156.90	22	63.86	CHANGED	p+plpppl+hA+LP.httslEshDasts.ulDcchltpL.tshsalcptpNlllhGPsGsGKTaLAsAlGhpAsc.tGapVhahpsscLlppLptA+t-Gphtptlppls+s.cLLIlD-hGhhPhsppsuphlFcllscRYE+pShllToNhshupWsclhu.DsslAsAlLDRLlHpu.chl	...........................................................................................................................................................................................h...............p......p........t.......p.......s........l..l.h...hG.s.s.GsG....K.o.a.L..A.s.A....l......u..............t................p........h..............h..........p......p..............u....h.......p...........s.......h.....h...h.....p....h......s...............c....l....h...p.........p...........l.......p.......p...........s.......h.......p......p.......s......p.......h...........p.....p.......h......l......p............p.....l......t...p....s....c....l.....L..l.lD...-..l.........G........h.......................h.......s....p................t.........t..........p........h.....l....h......p......l.....l..s...p.....R..h.......p.......p...t.....s.....h.l.....h.T.oN.hs....hp....p......h...t..p..h...hs.......p............................................................................................................	0	465	857	1042
+3112	PF02189	ITAM		Immunoreceptor tyrosine-based activation motif	SMART	anon	Alignment kindly provided by SMART	Motif	\N	21.10	21.10	21.10	21.20	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.63	0.74	-6.93	0.74	-3.24	12	339	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	49	15	123	429	0	21.10	35	14.82	CHANGED	-tlYpsLspcpcsp.YspLspp	..-tlYpsLppspcsp.YssLst...	0	9	10	16
+3113	PF01156	IU_nuc_hydro		Inosine-uridine preferring nucleoside hydrolase	Finn RD, Bateman A	anon	Prosite	Domain	\N	27.80	27.80	27.80	27.90	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.17	0.70	-5.21	118	5444	2009-09-11 13:52:43	2003-04-07 12:59:11	14	17	2525	62	1248	3860	1059	302.10	28	95.00	CHANGED	hpplIlDsD....sG.......h...........DD.AhAlhhuh...t.ps.p...................l...clhulTsl............G..Ns.slcpsspNuhpllphh..............h....ts...lPVht.....Gss.........tP............................t.hhs....tphH....GpsGlss.........................................................................................................h..........sttt...tptp........As............phlhctl.p..ptssc......lsllslGPLTNlAhslptt.Pc.........lhpplcc.....lllMGGuht.................hGN.......................h.ssh...A................EaNha.sDPcAAchVh.s........shs...lshl.sL-..lop....p.....shh.............s.tpthppl....tt.....................ss.shuphltp.hhp.hhhph....................tshshaDslssuhh...h..........Pph...............................................................................................p.spp.hhlsV-ss........s.hshGt............o.ls-.......................t.ssssplsh..plDs.......ptFhphhhp.hlt....ths	.....................................................................................plllDsD..........PG..........h........................D.DAlAlhhAl.....t.pP..c........................................l....-lh...ulos.ss.............G...Ns.....sl.-......p.....s..hpNuhp.l..lphh...........................................t.......pp.........l.P..Vht...Gus...pP..Lh..c.....................................hh.hs........spl.H.....................GpsG.lss..........................................................................................................hs...........................sptth......t.stp......As.......................phlhctl...p......p.s.s...tp..........lTllshGPLTNlAhh.lppp..Pc.................lhpplcc.....lVlMGGuht............................hGN.........................................h..oP..s..A.................EaNla....sD.PEAAph..VFpu..........uhs......................lshs..uL.D...lTp....p.......sh.l.......................................o..sc.h.h.p.phtp...............................................ttt.....su.ph.ltp..lhs...aahphph...........p.t........hsGh.lH.D.sh.s.luhl......l.......p..................P.pl..................h................................................................................p....h..pp..hhlp.V-sp...........u.hstGt...T..lsD....................................t.hsp.sssplhh....sl.Dh...ptFhphhhc.hh...hh.............................................................................................................................................................	0	384	731	1025
+3114	PF04183	IucA_IucC		IucA / IucC family	Bateman A	anon	Pfam-B_1982 (release 7.3)	Family	IucA and IucC catalyse discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate [1]. This family represents the N-terminal region.  The C-terminal region appears to be related to iron transporter proteins.	25.00	25.00	26.30	25.60	24.50	23.80	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.57	0.70	-5.13	168	2438	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	938	17	394	1532	11	241.30	25	40.66	CHANGED	sttsahph....Ep.ulhtGHPhHPssKuR.Gastp-httYuPEhsssh...pLpWlAlccshhphts......................tth...........htpthsspthtt..h.t............................shtsssah.llPlHPWQhppllt...sthts.lspspl.......l.LG...tust.ahsspSlRTlh.....shs....ps.....hhlKhulslp.Tss..hRslssppltsustlsphLpplhtp.-.hh.....pp..shpllpEsAuhshptst..........................th.tctluslhR-sshth..httt.......ppshs..hAuLhpss	...........................................................s.tsaht.EQ..slhpGHPhHPssKu+hGhs.t..p.-.httYuPE..htp.sh...pL.palAlc+shhttps........................tsh....pph.............lpptlssphhpt.htphh.........................................................t.shp...scahhlPVHPWQhcpllt....s.att.lspthl.........l.LG....tstp.ahsspShRTlh.............................sh.s............ps..........halKlslslp.Tus..hRslsspphtsusthschLpplhpp..-.hh.....tp.....thplhtEsuuhshtspp....................................phhppLuslhR-s.hth........tsp......ppshs..hAuLhtp.t.....................................................................	0	100	225	321
+3115	PF01419	Jacalin		Jacalin-like lectin domain	Bateman A	anon	Bateman A	Domain	Proteins containing this domain are lectins.  It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein (Swiss:P15501).	21.30	21.30	21.40	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.81	0.71	-4.26	52	1166	2009-01-15 18:05:59	2003-04-07 12:59:11	12	54	224	165	665	1119	2	122.50	23	46.35	CHANGED	Gs.WDDG...sa-uVcKlhVutupsuIs.........hlcF-YsKsst.h.spp+Gtps......htscpFplshs.sEalsuVcGhYcp.........tssllsuLpF+TNKppou.hhG.......sGpcFsLp..pGpKIVGFHGpuu.p...hlpulGsYhss	..........................................................................t.h.hp....hh.h..s.....hlt..........lp.h.pY....p.t...s.......t.........s..ttt...Gstss...............thpp.............hpl.s.hs..sEal.....splpGpast..................................t.shl.puLp.....Fp.....T.....sps......p.....h.....s..s....hhs..........psGs..tF.s..h...ss.........p.s.t.pl.....lGF..a.G+uu..t........hlculGsah.............................	0	227	342	470
+3116	PF02375	JmjN	jmjN; 	jmjN domain	Bateman A	anon	[1]	Family	\N	26.00	26.00	26.40	27.40	25.30	25.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.36	0.72	-4.42	65	1103	2009-01-15 18:05:59	2003-04-07 12:59:11	12	65	271	51	660	1080	7	34.20	45	3.06	CHANGED	PlFcPThEEFpD.hpYlpp..Icp....hut..chGlsKllP	.PlFcPThEEFc.DshtY....Isp..Ics.....ut..+sGIsKllP.....	0	166	312	494
+3117	PF03957	Jun	JNK; 	Jun-like transcription factor	Finn RD	anon	DOMO:DM01956;	Family	\N	20.90	20.90	24.10	22.40	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-12.06	0.70	-4.64	8	302	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	169	1	108	298	0	171.70	38	70.40	CHANGED	METPFYtDDuLSuh....tuuua............s.........u.ss.....shlhK.pohsLNLo-s.uuuLK.Pstt......tstu..ststsuGL.LsSPDlGh.LKLASPELERLIIQS.NGLlTTTPT.PuQFLYPK..........s..lTsEQpsFAEGFVKAL-DLHKQNQ.Lsus..ssuutuASu..hsuP...hus.Au.uslhusuhtsE.PPVYANLSoasPss..s...usuasusohuauA.Ph.........sP.h....ss..PR.......hsALK-EPQTVP-sPS.G-SPP	...............................................................................................................................................................................................................................................ss-.....h.t..hplsos-LE+h..I........l.....s...ss.h.s....oP.s.ss....p....hhhs+....................s..lTcEQEGFA-GFV+ALs-LH..p..pNp...hsss......ss.u..ssss...........h.s......sss...Au.....s...ssh..su..s..hts-..sPV.Yss.....Lssassss......o..........sss.h.s.ss..s.hsas.....................s.h......................ssthP+..................hpuLK.EE.PQTVP-h...st.............................................................................	0	22	33	66
+3118	PF01486	K-box		K-box region	Bashton M, Bateman A	anon	Pfam-B_25 (release 4.0)	Family	The K-box region is commonly found associated with SRF-type transcription factors see Pfam:PF00319. The K-box is a possible coiled-coil structure [2]. Possible role in multimer formation [1].	23.50	23.50	23.50	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.16	0.72	-4.21	68	4553	2009-01-15 18:05:59	2003-04-07 12:59:11	12	15	1081	0	451	4266	0	93.00	28	47.14	CHANGED	asptssss.....htpsphpphppEhsKL+pplctLQ.....ps.RphhGEsLssLshKELppLEppL-pulppIRu+Kscllhsplcphp+KEcplpppNptLppKlt-	.......................................................................ptp..pph...ppE.ht...+L+p.p.cplp.......pp.....R.p.h.h...G..E....-..L..s..s..L.s.h.cELp.pLEppL-p....uLpplRs+K............tp....lh.h.pplpphp+...K.....-.....pp.l.pctNp.Lppph.......................................	0	56	254	350
+3119	PF02960	K1		K1 glycoprotein	Bateman A	anon	Pfam-B_345 (release 6.4)	Family	\N	21.20	21.20	21.50	23.30	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.83	0.71	-4.10	4	847	2012-10-03 02:52:13	2003-04-07 12:59:11	9	4	3	0	0	751	0	99.90	76	46.82	CHANGED	GLSSRLSNRICFWApCANITPETsTVSVSSTTGFK.............h.pTNtLlpIIPATTHAlVVVEEVKSppPaIpV.FLVFMTLVALIGTMCGILGTIIFAHCQKQSDSNKTV.QQLRDYYSLHDFpTEDYTQPVDWY	...GLSSRLSNRICFWApChNITPETaTVSVSSTTGF+TFSTNuLlp..II.ATTHsVVVVcEsKSTNsHIpVPFLVFMTLVALIGTMCGI.L...................................................	0	0	0	0
+3120	PF02149	KA1		Kinase associated domain 1	Mian N, Bateman A	anon	IPR001772	Domain	\N	20.80	20.80	21.10	21.40	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-8.02	0.72	-4.51	26	802	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	272	3	433	777	1	46.20	40	6.17	CHANGED	tsssl+FElplsKl......shhGlch+RluGssahapclssplLppL+L	......s.tshlpaEhEVCKLP.p..........huLsGl+FKRl.u.GsuhsaKslsscIhs-L+L........	0	138	206	321
+3121	PF02524	KID	KID_repeat; 	KID repeat	Bashton M, Bateman A	anon	Pfam-B_1382 (release 5.4)	Repeat	This is family contains the KID repeat as found in Borrelia spirochete RepA / Rep+ proteins.  The function of these proteins is unknown. RepA and related Borrelia proteins have been suggested to play an important genus-wide role in the biology of the Borrelia [1].	20.80	15.10	21.20	15.10	20.10	15.00	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.75	0.77	-5.93	0.77	-2.78	28	617	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	25	0	37	464	0	11.00	84	15.55	CHANGED	KIDsVEpsLpt	KIDsVEKNLpp.	0	37	37	37
+3122	PF00050	Kazal_1	kazal; 	Kazal-type serine protease inhibitor domain	Eddy SR	anon	Prosite	Domain	Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family Swiss:P46721.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.05	0.72	-3.94	51	1792	2012-10-02 00:52:43	2003-04-07 12:59:11	16	207	356	88	938	4387	283	52.00	31	19.67	CHANGED	Csph.............Cs...tphpPVCGoDGhTYsN-Ctl....C.....ppppslplp+pGtC	.......................................................................................Cs.......tp.h.pP...VC....G..o.......D...u....p.....T...Y...sN.c.Cth...................C......................pp....t....t..p...l..p...l..t..p..G.C....................................	0	276	378	621
+3123	PF03522	KCl_Cotrans_1		K-Cl Co-transporter type 1 (KCC1)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	28.00	26.80	24.50	23.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.14	0.72	-4.44	3	128	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	40	0	48	150	0	29.80	66	2.91	CHANGED	VKDRNShLRLTSlGSDEDEETEAusEKVHM	.VKDRpShL.RLpSlhSDE-.-Eo.tsht...-KlpM....	0	2	5	18
+3124	PF03520	KCNQ_channel	KCNQ1_channel; 	KCNQ voltage-gated potassium channel	Griffiths-Jones SR	anon	PRINTS	Family	This family matches to the C-terminal tail of KCNQ type potassium channels.	25.00	25.00	25.20	25.20	24.50	24.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.43	0.71	-5.00	9	568	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	136	9	208	521	1	163.00	42	29.81	CHANGED	R+Ssusslss....hsuSPoKs.p....ShuFscRo+hh.shh...........ss.usuhD.lt-EcthpC.hphppLpsshKssIRslRhhKaaVAKRKFKEsL+PYDVKDVIEQYSAGHLDhLsRIKpLQtRlDQIlGKsshhsccp.+sK............shtphShhuRVsKVE+QV...tslEpKLDlLlsh...........appphttssssshshsssphP	....................................................................................................p.s......ttSPsKs.K....uh.uhssRsR.h.p.uhthps.t......................ttt.h.s..-...h...-.-..c.sht..s.-...h..hp...-lhs...s...lK.ssIRul.R..hh+FhVuKRKFKEs...LRPYDV+DVIEQYSAGHLDMLsRIKpLQs.R.............lDQIlG+s......ss+.c.+.p.K.........................................c.p.ShhuRlsKVE+.QV...tsh-pKLD..hLlsh............h.phht..s........................................................	0	34	52	115
+3125	PF03812	KdgT		2-keto-3-deoxygluconate permease	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	25.30	25.10	19.80	22.00	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.09	0.70	-5.27	3	900	2012-10-02 17:06:44	2003-04-07 12:59:11	8	5	674	0	114	494	12	292.30	53	95.17	CHANGED	MKIKpoIEKIPGGMMLVPLFLGALCNTFoPGAGKYFGSFTNGLITGTlPILAVWFFCMGASI-F+ATGTlLRKSGTLVVTKIAsAWVVAlIAupFIP-DGIQsGFFAGLSVLALVAAMDMTNGGLYAALMNQYGoKEEAGAFVLMSLESGPLMTMVILGsoGIAoFEPclFVGAVLPFLlGFALGNLDPDLR-LFSKuVQTLIPFFAFALGNTINLoVIlQTGLLGIFLGVuVIIVTGIPLILADKFIGGGDGTAGVAASSSAGAAVATPlLIAEMsPuFAPVApuATALVATSVIVTSlLVPIlTulWuKKlK	....................MpIK+slE+lPGGMMlVPLhlGALhpTFuPtA...hc......hG..uFTs.uh.h..s..G..s..s..P.IL.ulahhCMGAsIplpAs.spsL+.KuG.oLs.loKlulAhlluhlsu+lhstcG.l......hGLSsLAllAAMs.oNGGLYAulhtpYGsc...............c-u...GAhslhSLpsGPhhTMl...hL...GsA.GlA..s..h..hshVusllPhllGhhLGNLDs-hR-Fhscus.sLIPFFAFALGssIsLshlhp.sGLhGIL.LGlhslhlsGh..h.IhAD+.L...l....u...G.....G.s..G.sA..Gh..AA..SSoAGsAVATPshIAphsP.u.F.p..s.hAsuAT..ulVAsuVIlTuILsPlLTuhhu++................	0	29	52	90
+3126	PF03814	KdpA		Potassium-transporting ATPase A subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.30	20.30	22.30	22.20	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.82	0.70	-6.50	14	2239	2012-10-03 11:11:44	2003-04-07 12:59:11	10	6	1897	0	441	1655	66	488.70	47	98.06	CHANGED	IhlhlsllsslshsLGtYlt+Vatsp+.............shhs.lhsslEphlY+lhGlsPcp-MsW+pYhhAlLshNlhhhlllahllhhQusLPhNPsshsuhs.cLAFNTAlSFlTNTNhQsYuGEsohSYhSQMhulTh..FsSAATGlAVuhAhlRGlstppsstLGNFasDLlRshhRlLLPluhllAllLlhtGlPQTLtu..hsssTLpGuhQpIshGPVAS.EAIK.LGTNGGGFFsANSAHPFENPsshoNhlchluhhllPsAhhasFGchltsp.....+QuhslhsshhllaluhsslshhuEhtGN..PhlpsLGlp........suNMEGKEsRFGhutSuLaAlsTTusosGuVNuMHDShTPlGGhlsLhtMhLspl.hGGhGsGlhshlhallLsVFluGLMVGRTPEaLGKKIEu+ElKhssLslLlpPlhlLl.oAlAhslPsuhuuhsNPG.HGhSElLYtaoSAuANNGSuFuGLssNT.aaNlohGlsMLlGRalsIlshLAIAGSLAsKpssPtosGTlsTDssLFsuLLlusllIlGuLTFhPsLALGPIu...EtLs	...................................................................hhhlhllhlluhPLGtalt+.lhpsp...................h...h.h.s.lEphla....+lhGlp....s....t....tcMsW+pYhhulLshNhhshhhlahlhhhQthLPL.N.Ppt................h.s.u.h.s...cLAhNTAlSFlTNTNhQtYoGE..sslSYhoQMhGlsh.pFlSAAoGlAVhhAllRu.h..............s...................t.......p.............p................h........p.......................s...................lGNaWsDlsRhslhlLlPluhllAlhhltQGs.Qshp..................s.h.t.................l.......p.........T.....l............p.................G............s..........p...Q.........h.....l.....shGPVAS.EAIK.LGTNGGGFFsuNSuHPFENPoshoNhlphhulhLIPsALsasFGchstcc.............................RQ....GhhlhhuMhhlFlhsls.lsh.huE.hpGN..Phl.t.sh.G.htt.............................usNM.EGKEsRFGlh.............h..............SuLFu.ssTTusSsGuVNuMHDShTsLGGhlshh.M.lspV.FGGVGsGLhshllaslLuVFIuGLMlGRTPEYLGKKI-s+EMKhs.sLslLlpP.hllLhhoAlA....h.........h....h......s..........u.......u........t...s.....u............h............hN........P.....G...............HGhSElLYthoSAAsNNGSuFuGL.s......s........N......T................s................F.............aNhhhuhsMhlGRFhsIlshlAlAGSL..........ssK.....+..h........s.t.o..s..GTlsTcsshFsslLlsslllluALTFhPsLuLGPlAEaL............................	0	126	260	357
+3127	PF02669	KdpC		K+-transporting ATPase, c chain	Bashton M, Bateman A	anon	COG2156	Family	This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilise the Kdp complex [1].  It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA [1].  The K+ transport system actively transports K+ ions via ATP hydrolysis.	19.90	19.90	20.10	20.10	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.13	0.71	-4.60	3	2067	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	1913	0	393	1342	41	180.70	42	95.45	CHANGED	hRsLlPALoohllLhlITGlVYPLlVTVlGQLaFPaQANGSLIc-u.GQVlGSALIGQsFTusGYFHuRPSAsu-u.....YssuASGGSNLAPSNP-LLutIAARVsAhRtEN..sAuspVPVDLVTuSGSGLDPsISPsAAphQhPRVAKARNISlcQLppLIsKHT-uRhLGalGEPuVNVLcLNLALD+L	.......................................h...lpsulthhlhh....hl.l.s....Ghl..YPLlhTuluQ.h.h.FstQ.ANGS..Ll.p......ps.....s.......p..............l..l..GStLIG.....Qs.....F.........T...............s......s.......t.........YFaGR.....P.....S.....A.ss.t.................Ysst.......u...S.GGS.Nhus.......o.......N.............P..............cLtpplp........t.+.......l.s...t.h.............pt.......tN............s.s.....s.....s.....V.....P..sDL.VTuSuSGLDPcIoPpuAthQlsRVAc..A......R........s..........l.sh...pp...lppL...l...scpopt..h.huh...lG.ps.hVNVLcLNlALDp...............................................................	1	117	235	323
+3128	PF02702	KdpD		Osmosensitive K+ channel His kinase sensor domain	Bashton M, Bateman A	anon	COGs	Family	This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport [1].  The aligned region corresponds to the N-terminal cytoplasmic part of the protein which may be  the sensor domain responsible for sensing turgor pressure [2].	26.10	26.10	26.20	28.40	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.12	0.70	-5.20	21	2010	2009-09-10 15:55:13	2003-04-07 12:59:11	12	29	1860	2	394	1489	34	208.40	55	27.21	CHANGED	scRG+L+IalGhAsGVGKTYsMLp-A+chhcpGhDVVlGhVETHGRs-TtshlcGLthlPh+plpY+GhtLpEhDlDAlL.tR+PpllLVDELAHTNssGSR+cKRaQDlEELLsAGIDVaTTlNlQHlESLNDlVppITGlpVRETVPDpllcpAD-lhllDlsP--LhcRLppGKlYts-pscpAlsNFFphsNLsALRELALRcsADcV	.......pRG+LKlahGAusGVGKTaAMLscApcht.tpGlDlVl.GlVETHGRt-..TsAhl..-G...LthlPh+pl...pY+...G+plpEhDLDAsL....tR.........+.........P.s.llLlDELAHo.....Ns.....PG...S......R...H............KRWQDlEELLcAGIDVaTTVNlQHLESLNDlVp..tlTGlpV+..ET.VPD.hhcp.AD-l.LVDlsP--LhpRLpcGKVYhs.c........p.s.-pA.l.......psFFphuNLhALRELALRcsAD+V..............	0	120	245	325
+3129	PF04962	KduI		KduI/IolB family	Bateman A	anon	COG3717 & Pfam-B_11840 (release 10.0)	Domain	This family includes the 5-keto 4-deoxyuronate isomerase enzyme EC:5.3.1.17 that is involved in pectin degradation. This family aldo includes bacterial Myo-inositol catabolism (IolB) proteins. The Bacillus subtilis inositol operon (iolABCDEFGHIJ) is involved in myo-inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction system mediated by IolR [2]. The exact function of IolB is unknown. Members of this family possess a Cupin like structure.	20.10	20.10	20.10	20.60	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.73	0.70	-5.31	72	2006	2012-10-10 13:59:34	2003-04-07 12:59:11	7	5	1578	16	396	1311	510	252.20	30	91.15	CHANGED	LLs+s.t...psGp...lhploPcsA.....sWpalGFplhcLtsGpshphp.....ssspEhslVll...sGpssVss....ts...patplGsR.toVF-.......tsPtulYlPsspphplsA.tss...sclAl.ssAPupssh..ss+.hlsPsslshptRGpGssp....RhVpsIhspsps....AcsLLVsEVh.TPuGsWSSYPPHKHDp-s.s....tEohLEEsYYa+lsPsp..........GFuhQRVYo....-.....DcslD-shsVpstDVVhVP+GYH.PsssssGY-hY.YLNVMAGPp..RtWthps-PsHpWl	................................................................hh.hhh..........t.....hhph.sp.h.....shthh.s.h.p...h...h.h.h..t.sGcshp.h.......hpcRElsllsl.......uGsuslps.........-G...p.hhclGpR................-ulYls....pus.c.........s....lhu....tss.........A+...hh.l.ssAPA....+..p.sa......Ps..+.....hl.s.......ss...........-............s....s........s..................p.....hG..c..s...tss..............Rplpphh.....ss......s.......sh......tsspL.hu.sh.sPGuhWsohPsHpH-cc..s......t.p..ppsa.aat.hpPpp..................hh..................t...sc..ph..s..lpNcp.sVls.P.ph.....sltuusGhcsY.alhsMsG.s...........p.h...hsD..cH.h..................	0	122	254	318
+3130	PF02422	Keratin		Keratin	Bateman A	anon	Pfam-B_1920 (release 5.4)	Family	This family represents avian keratin proteins [1], found in feathers, scale and claw.	25.00	25.00	25.10	25.10	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.58	0.72	-4.03	4	299	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	20	0	238	304	0	100.70	56	90.20	CHANGED	SChs..L.CtP..Cs...PTPLAsSCNEPCVRQC.DSoVVIQPssVVVThPGPILSSFPQsosVG.SouA.AV..GShLutp.GhshuSGGa.GLuGaGGpYsG.hst.s	.......................................SC.s........CtP...Cs....PsPLAsS.CNEPCV.RQCQDSpVVIQPsPVVVTLPGPILSSFPQNTuVG.uST.SA...AV......GSh...L..Ssp....Gl........P..I.o..SG....G.F.....sl...u..shus..t.hs.G.hs.............................................................................	0	0	0	98
+3131	PF01500	Keratin_B2		Keratin, high sulfur B2 protein	Bateman A	anon	Pfam-B_706 (release 4.0)	Family	High sulfur proteins are cysteine-rich proteins synthesised during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments [1]. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat [1]. This family is also known as B2 or KAP1.	27.60	27.60	28.00	27.60	27.40	27.50	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.61	0.71	-12.53	0.71	-4.47	8	307	2012-10-03 03:07:01	2003-04-07 12:59:11	12	11	41	0	85	433	0	97.90	45	90.76	CHANGED	M..ACCuTSFCGFPoCSTuGTCGushCQPsC.p....................................oSCCQPoCspTSCCQPhs..oSCCpPo......................CpP.shQTSCCQPTChQTSuCpTGCGIGGuhGYGQ.GSSGAVSoRhRWCRPDCRVEGTCLPPCCVVSCTsPoCCQLaaAQASCCRPSYCGQSCCRPsC.......CC.............CsEPoC	............sCt......s.hSo.u.CG........p..............soCCpsssspTosCp.P................................CppP.sC.hpsssht..p.us...................................................................................................................................	0	17	17	18
+3132	PF04579	Keratin_matx		Keratin, high-sulphur matrix protein	Waterfield DI, Finn RD	anon	Pfam-B_4676 (release 7.5)	Family	Family of Keratin, high-sulfur matrix proteins.  The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulphur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas microfibrils contain the larger, low-sulphur keratins (40-56 kDa) [1].	25.00	25.00	32.40	94.70	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.43	0.72	-10.87	0.72	-3.71	4	69	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	27	0	36	73	0	96.40	74	96.39	CHANGED	ACCAhhCCSVPTGPATTICSSDK.CRCGVCLPSTCPHsI.LLQPTCC.DNsPPPCphPpshVPTCFLLNSsHPTPGLpuINLTTYlQPGCEpPC.PRC	..........CCss+...sCSVPTGPATTICSSDKsCRCGVCLPSTCPHpl.LLpPTCC.DsCPPPCplPp.....shVPTCaLLNSspPTPGLpsINLTTasQP.sCE.....PC.PpC.....	0	3	3	5
+3133	PF03882	KicB		KicB killing factor	Bateman A	anon	COG3006	Family	The kicA and kicB genes are found upstream of mukB. It has been suggested that the kicB gene encodes a killing factor and the kicA gene codes for a protein that suppresses the killing function of the kicB gene product [1]. It was also demonstrated that KicA and KicB can function as a post-segregational killing system, when the genes are transferred from the E. coli chromosome onto a plasmid [1].	20.00	20.00	20.30	21.20	18.00	19.90	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.54	0.70	-5.86	3	769	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	745	10	73	342	4	428.70	78	99.75	CHANGED	MSEFSQT.....IPELVoWAKcpDFSLNLPTERLuFLLAIAlLNNERLDGEMuEGELVDAFRHVocAFEQSoEAIAsRANNAINDLVKQRLLNRFTSEhTEGsAIYRLTPLGIGITDYYIRQREFSsLRLSlQLSIVADElpRAuDSAEEGG-....EaHWRRNVFAPLKYSVAEIFDSIDLoQRlMDEQQQSVKD-IA-LLNKDWRAAISSCEtLLSETSGTLRELQDTLpAAGDKLQAQLLRIQDCVhG+DDLaFIDcLloDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFSQRLRQSlpcYFDcPWaLTYAsAERLlDLRDEEMsLRDEEVTGELPEELEYEELs-l+DQLAp+Ip-hLtVYKEpssPIDLuLVLREYLusYPRoRHFDVARIVVDQAVRLGhApuDaoGI.PDWQAINDaGAKVQAHVIDKY	......................................................MSEFSQT.....VPELVAWARKNDFSISLPsDRLuFLLAlATLNGERLDGEMSEGELVDAFRHVS-AFEQTSETIuVRANNAINDMVRQRLLNRFTSE.AEGNAIYRLTPLGIGITDYYIRQREFSTL.RLSMQLSIVAuELKR.AADAAEEG.GD....EFHWHRNVYAPLKYSVAEIFDSIDLTQRlMDEQQQQVKDDIApLLNKDWRAAISSCElLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMs.+.D.DL.aFVD+LVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDK.N.RVFAQRLRQSVQsYFDcPWALTYANADRLLDMRDEEM.uLRDEEVTGELP.DLEYEEF.NEIR.E.QLAAlIE-pLAlYKs+QsPLDLGLVlREYLuQYPR..ARHFDVARIVlDQAVRLGVApADFo.GL.PAcWQsINDYGAKVQAHVIDKY..................................................................................	0	8	23	49
+3134	PF04383	KilA-N		KilA-N domain	Aravind L, Iyer LM, Bateman A	anon	Iyer LM	Domain	The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease [1].	21.00	19.70	21.00	19.70	20.90	19.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.46	0.72	-4.44	139	2605	2009-01-15 18:05:59	2003-04-07 12:59:11	8	39	812	3	1531	2312	29	103.00	27	37.07	CHANGED	hphsphplll.pp.p.ss...alNhTcltchs.....t...Kc......hppWh+pcpopcllpphppt.s...........................................h...............................h...tttpttp.........hp.G...sY.lH.clshplA.pW.ISs.paslhl.chlpphhpt	.................................................h.l..cp.p..ss...hhphpslhpst......t.pp.+p.................pcWhcsppTpEllpphppth.ht.......................................................................................................................h.h.s.ptthsst.........hp.G...hY.lHc.Ll.shA.hW..hSP.cathhlhchhDplpp..................................................................	2	1330	1420	1504
+3135	PF02172	KIX		KIX domain	Bateman A	anon	Pfam-B_4149 (Release 4.2)	Domain	CBP and P300 bind to the CREB via a domain known as KIX [1]. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.	21.20	21.20	23.40	23.10	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.58	0.72	-3.93	6	242	2009-09-11 11:24:58	2003-04-07 12:59:11	11	28	90	6	142	201	0	78.30	70	4.11	CHANGED	shcKsW+cplTpDLRsHLVcKLVpAIFPsPDssAhpDpRMcsLluYA+KVEt-MaEpApsR-EYYHLLAEKIYKIQKELcE	............G.h+KsWHEclTQDLRNHLVHK....L........VQAIF.PT...P..DPAAL.K..D+RMENL..VAYARKVEGDMYEoANoR....sEYYHLLAEKIYKI.QKELEE..........	1	45	57	101
+3136	PF03037	KMP11		Kinetoplastid membrane protein 11	Griffiths-Jones SR	anon	Pfam-B_1062 (release 6.4)	Family	Kinetoplastid membrane protein 11 is a major cell surface glycoprotein  of the parasite Leishmania donovani.	25.40	25.40	25.40	139.80	24.70	25.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.14	0.72	-3.40	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	19	0	4	44	0	88.60	90	97.89	CHANGED	MATTYEEFuAKLDRLDsEFsKKMpEQNtKFFADKPDESTLSPEMKEHYEKFEKMIQEHTDKFNKKM+EHSEHFKtKFAELLEQQKNAQaP	MATTYEEFuAKLDRLD-EFNKKMQEQNAKFFADKPDESTLSPEMKEHYEKFERMI+EHT-KFNKKMHEHSEHFKpKFAELLEQQKAAQaP..	0	1	2	4
+3137	PF03790	KNOX1		KNOX1 domain 	Finn RD	anon	Pfam-B_533 (release 7.0)	Family	The MEINOX region is comprised of two domains, KNOX1 and KNOX2.  KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerisation [1]. 	20.50	20.50	20.80	20.60	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.17	0.72	-4.63	30	1800	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	158	0	141	642	2	43.00	58	16.60	CHANGED	sslKAKIhuHPpYspLLsAYlsCpKVGAPPElsshL-tlppctcs	......ulKuKIluHPpYPpLLuAYlDCQK.....lGAPPE.VVucLDtlopEhp....................	0	14	85	119
+3138	PF03791	KNOX2		KNOX2 domain 	Finn RD	anon	Pfam-B_533 (release 7.0)	Family	The MEINOX region is comprised of two domains, KNOX1 and KNOX2.  KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerisation [1]. 	20.80	20.80	21.00	21.10	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.67	0.72	-4.69	20	1804	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	164	0	135	669	0	34.80	65	13.37	CHANGED	sssslGsDPELDpFMEsYCclLsKY+-ELo+Pac....EAhsFLpcIEsQLssLst	......th...sIGhDPE.LDQFM..EAYC...EMLhKY+ppL..............................	1	13	84	115
+3139	PF00051	Kringle	kringle; 	Kringle domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.	26.30	26.30	26.70	26.30	25.60	26.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.28	0.72	-3.88	24	2697	2009-01-15 18:05:59	2003-04-07 12:59:11	13	237	179	118	1376	2545	55	76.90	39	21.44	CHANGED	ChpGsGpsYRGshupTtSGhsCQtWsuphs+phsh.sspp.sstsLtt...NYCRNPDG-tc.PWCYT.pssphpaEaC.slspC	......................................................Ch.p.s.s.G..psYRGsh.s..h....T....t...oG....h.....p..CQtW.s..u....p.h..P..H....p.......a......p...h........p....s...p..p...h..s..........s..tsL.pc.................NY..C............R....N....P.....D....u.......c........t....p....P..WCYT....s.....s...s...p......h......p....a...-a.C.slstC.....................................	0	528	604	870
+3140	PF00197	Kunitz_legume		Trypsin and protease inhibitor	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	21.30	21.10	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.58	0.71	-4.72	17	766	2012-10-02 19:42:32	2003-04-07 12:59:11	13	4	124	55	109	793	0	164.40	31	83.53	CHANGED	sVlDs-Gc.lpsGGsYYllsthhutGGG....hphstsup..CPLsVVposs-ls...pGhPlphss.h..tssh.ssh...ohlplpFsshs.phsss.....hWpVscpptt.t..hVphuthcs...sp..s.hFKlc+sst.........YKLlaCstt...........ptCpslGlphD.tcshpRLllopp.sPlslhFpK	........................VlDspGct.lp..s.G..s.pYh.Ihs..shhs..t..uGs..........lth.s.s..ss..t.hC.P....s..Vlppst...p..s...pGh.P..VpFos......hpspsslIp.so.lslp.F.s..ss..o.s...ph.sss..............hW+.ltpp.............s...........s..s...........t.....sh...hVsTGGstu..............tshFKIpKhss...s.............YpLs.aCP.s...........ps.C.hslGhh.hp.....t.phLs.hsp....sh.hhF......................................	0	7	91	97
+3142	PF02442	L1R_F9L	L1L_F9_C19; 	Lipid membrane protein of large eukaryotic DNA viruses	Mian N, Bateman A, Coggill P	anon	Pfam-B_1868 (release 5.4), Iyer L	Family	The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV, have all been shown to have a lipid membrane, in spite of the major differences in virion structure. The paralogous genes L1R and F9L encode membrane proteins that have a conserved domain architecture, with a single, C-terminal transmembrane helix, and an N-terminal, multiple-disulfide-bonded domain. The conservation of the myristoylated, disulfide-bonded protein L1R/F9L in most of the NCLDV correlates with the conservation of the thiol-disulfide oxidoreductase E10R which, in vaccinia virus, is required for the formation of disulfide bonds in L1R and F9L [2].	21.90	21.90	22.80	65.90	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.42	0.71	-4.84	32	163	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	82	6	0	124	2	198.30	32	74.57	CHANGED	Musus..slp........slhsthsp+hhppLspp.sssssssC..slcIGplpsch.psCslpltNhC.sssphp...hshllpuhp-.shssLspcp+ttl............Atplshsl.ssssp..hpsplcppC.pupuslsspIsl...pslplspC.usssph.hphphlNoGoutuNCuhpulhsshsppss.....stltpp.pstspsh...hhlhhsllllhlhhlhhh	...........Musst..shp........ThhNhh.-+hhpcLtQp.sssssssC..sIcIGplhhch.+sCslplpNhC.usushp...hshllpuhpE.shssLspcp+shl............AtpIthsl.ssssp...h.splcpsC.supAslsNhlcI...Qsl.ls-CtussGph.hplphlNoGoupuNCulpslhpshsKtss.......Itpp.phshtsh...hhllhlllllllhslhhh......	0	0	0	0
+3143	PF05047	L51_S25_CI-B8		Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 	Wood V, Bateman A, Finn RD	anon	Pfam-B_9461 (release 7.6)	Domain	The proteins in this family are located in the  mitochondrion. The family includes ribosomal protein L51, and S25. This family also includes mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) EC:1.6.5.3. It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins.	21.00	21.00	21.20	21.20	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.29	0.72	-4.23	67	788	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	307	1	534	748	8	54.90	25	38.29	CHANGED	sRpFl.ppphsshp.tpNPpl.lhlpc...pss.p....PhlhucYtsG.............................pccplslcshss	............sRpFl.cpplsp....h....p.ppNPpl.lhlpc.....psshp........PtlhucY.t.pG........................................ppctlslcshp................................................................................	0	164	279	432
+3144	PF04604	L_biotic_typeA		Type-A lantibiotic	Waterfield DI, Finn RD	anon	Pfam-B_4608 (release 7.5)	Family	Lantibiotics are antibiotic peptides distinguished by the presence of the rare thioether amino acids lanthionine and/or methyl-lanthionine. They are produced by Gram-positive bacteria as gene-encoded precursor peptides and undergo post-translational modification to generate the mature peptide. Based on their structural and functional features lantibiotics are currently divided into two major groups: the flexible amphiphilic type-A and the rather rigid and globular type-B. Type-A lantibiotics act primarily by pore formation in the bacterial membrane by a mechanism involving the interaction with specific docking molecules such as the membrane precursor lipid II [1].	21.70	21.70	22.00	21.80	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.52	0.72	-4.32	15	102	2012-10-02 23:56:30	2003-04-07 12:59:11	8	1	70	0	6	64	0	48.00	40	91.69	CHANGED	Mcppp.......-shsuLpEVo.cELDplLGG...GsGVlpTISHEC+h.NSaQalFTCC	.........................Mcppp.......thhsulpEVS-cEL-pllGGt..GsGhhtTIoc-C........lhsCC..........	0	0	1	3
+3145	PF02502	LacAB_rpiB		Ribose/Galactose Isomerase	Main N, Bateman A	anon	Pfam-B_1105 (release 5.4)	Family	This family of proteins contains the sugar isomerase enzymes ribose  5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). 	24.40	24.40	24.40	24.70	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.55	0.71	-4.53	170	5002	2009-09-12 00:30:27	2003-04-07 12:59:11	13	13	3211	88	900	2738	1726	140.00	34	86.39	CHANGED	+I.uluuDHuGhcLKptlhpaLppp...s..h.-VhDhGstst.-...ssDYP-huhtlAptVs......ss.c....s-..........h.GIllCGTGlGhuIuANKltGlRAAlspDshoAchuRpHNsANlLsl........GuRllG.tlAppllcs.......aLsscFc....GGRHtp..Rlspl....s	...............................................+IslGs.DcuuhphK....phlhpaLcpp......G..a..-Vh.Dh.Gst.st.p..............pscYPphuhtlAptVs.........ss.p.........s-..............h..GIllCGTGlGhshuANKl.GlRuAlsp..D...hoAhhs+pcNsuNllsh........Gu+ll..G..t.t...lAppIlcs.........alss.cac.....ssRppp+lstl.....................................	0	348	631	790
+3146	PF00356	LacI	lacI; 	Bacterial regulatory proteins, lacI family	Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.07	0.72	-4.34	26	29289	2012-10-04 14:01:12	2003-04-07 12:59:11	16	36	3489	72	5798	19321	1208	45.90	41	13.66	CHANGED	Tl+DVA+hAGVShuTVSRVlNss...t.tVSppT+c+VhpAhcELsYtPN	...............TlpDlAchAGVShuTVSR.VlNsp............s..pV..o..p..p.T+c+VhpshccLsYpPN........................	0	1667	3424	4636
+3147	PF02450	LCAT	LACT;	Lecithin:cholesterol acyltransferase	Mian N, Bateman A	anon	Pfam-B_2099 (release 5.4)	Family	Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.45	0.70	-5.50	7	1122	2012-10-03 11:45:05	2003-04-07 12:59:11	10	21	550	0	521	1745	75	256.00	21	58.91	CHANGED	hhplWLsls........hFh.hshssWh..hphVhspsst..hh..tPtsplcs....sGFs..ts.uhEhLD.shlsGhh...appllpsLsshGYctsphltAu.YDWRluss...cpscYappLKthIEphhphp.sppVhLluHSMGs.lhhYFLh...tph..........hspaIcuFIsluuPhhGSs+sltslhSG.......spshshl.s.sht........p.pRhhsspsa.....hhPps......hsh...--cl..ssssh................Nhshtsh.pahtslsht.h..........hh.app........................hssLpssLs.sPthclYClYGsshPT.csYhah..............sthhshts.ss..........hhhs-GDsTVshhuhs...........hCppWhstps...........hphsH....hhsl+s.......spHlsllhps	.......................................................................................h...............................................hp..t..............ts.th.............t.t........sh.....h...s......h............................................ht.......hlpt.L.h.t.......G.Y.......s...p....t..h...h.us....YD..W.Rhs.t......................t..p....h.h....p...p....L..t.th.l.............E.........p....h.....h........t.......h..........s.........p..................lh..lluHShGsh.h......h..h.......h.a.h...p..................................h...p...ph...l....t...th..l.lu.s...s.....h.h.G.s....t..s.....h........h.h........G......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t........................................................................................................................................................................................................................................	1	192	317	431
+3148	PF04369	Lactococcin		Lactococcin-like family	Finn RD	anon	DOMO_DM04110	Family	Family of bacteriocins from lactic acid bacteria.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.80	0.72	-4.05	3	23	2012-10-02 23:56:30	2003-04-07 12:59:11	8	1	16	0	4	19	0	51.00	27	76.43	CHANGED	MKNQLNFNIVSDEELSElNGGpLpal.SsGshsWYpsTsTuKTlsQQTpssauAshsshs	.............p.pap.lS-pELuplsGGshshhQs.sushshh.pt.sthhh.tQs.ssh.hth.s.........................	0	0	0	1
+3149	PF01306	LacY_symp		LacY proton/sugar symporter	Finn RD, Bateman A	anon	Prosite	Family	This family is closely related to the sugar transporter family.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.52	0.70	-5.92	4	1275	2012-10-03 03:33:39	2003-04-07 12:59:11	14	7	574	10	131	2345	309	380.70	39	96.84	CHANGED	hhsh+NpsFahFuhFFFFYFFI.MusaFPFaPlWLp-VstLoKT-TGIlFSClSLFuIlFQPlaGllSDKLGL+KpLlWsIohlLVhFAPFFIYVFuPLLQhNIhsGullGGlalGhlasAGuGAlEAYIE+sSRsspFEYG+ARhaGClGWALCAohAGIhFoIsPplsFWluSGhAllLhlLLhhuKs-sspoAhVhDAlGANppsFSh+hshpLF+..phWhFllYlVGVussYDVFDQQ.FAsFFpuFFsosptGT+lFGalTThGElLNAlIMFhsPhIlNRIGuKNALLlAGsIMolRIlGsuausoshEVlILKhLHhhElPFLlVGsFKYIousF-sRLSATlaLIGFphuKQLuhllLSshsG+hYDphGFQssYhlLGhIslohTlISlFTLSust..hlh.sst	............................................................h........h....h.ul.h...a..F..h.Y.FFh....h...u.h.a...h...P...F...a....s.....l...W..L.....+.....s.......h..G...L..o..s...s....s.....h.....G....lla....us.h.tL...hu.lh.h...t.s..l.h..G..lluD....+......L...G.h....+..K..h.....L.....l.....h......h...l......s....s......l...h..l..L...h.u......P.....F.....h....l...a....l.....a.....u.....P.....L.........L...p....h....N....h....h......h...G...s..l..l..G...u...l....a...h...u...h.....s...F..s.u..G.....s...s...h.h...-....A....a..h......-.+...h....u......R...p........s.......F....E......Y....G..+..s....R...h.....a...G.....S.l.G....a..A.l..s......u.....s.........l.....s..G.......h.........h.......a......o.....l........s...s.........p.........h.........s..F..W.....l...s..S...s.....................h...u...l...l.h.h..l...L...h..h...h...h.....+...s.....s..................p..s.........h...h.....p...s.......G....A.s....+...p....s..........h....o....h...t.....s.h......t.L.h..+.......p...h....W....h...h..l.....l...a...Vl....G...l..p.......s...s....Y.s.l....aDQQ...F...s.s.F.a.s.sa....F..t.....o...s....p.......G.....s...p...s.a....G.....Y....l..s....oh..G.l.h.E.uh.l.M.h.h....u.P..hl...ls.....R..l.G.....u.+....s..sLL.l..u.uh..l.Ms.....lR..I...h..G...s.u.h....s...T...s...s...h......l...l...l.l...K...h....L..Hs..h.....E.h....P.l..h..ll.u...s....F..K.YI..s....u.p.F.......-...s...+........l..S.u........T....l......a.h....Vs....a...s.h..u.p...p.l...uh...h...l...hSshA.....G......h...h....Y...........-.......p.........l.....G....ap..s...s....a...hl..h....u....h.l..s.L.h....h..hl.h.uhFh...Lpt.t........s.................................................................................................................................................................................................	0	19	50	90
+3150	PF00961	LAGLIDADG_1	Intron_maturase; 	LAGLIDADG endonuclease	Bateman A	anon	Sarah Teichmann	Domain	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.38	0.72	-3.46	91	1228	2012-10-03 01:41:40	2003-04-07 12:59:11	14	21	340	88	258	1340	92	96.80	21	50.58	CHANGED	lsGFhDu-GsFplshpppp...................ht.....................h.hpFplshc......c-htlLptIpphhs....................hGplphppss...shpaplss...p.hphllshFspYs..lhopKhhcahpapchh	....................lsGFh-....u...-GsFtlshpppp...................................................................................................phpI...s.p..............pchtlLphlpphhu....................................hGpl..th.....p....pspp...........hhpapl...ps...ppththlls..hh.....s...p.h......hho.p.K.h.h.pahhahp.............................	0	77	194	231
+3151	PF02264	LamB		LamB porin	Bateman A, Mian N	anon	Pfam-B_4810 (release 5.2)	Domain	Maltoporin (LamB protein) forms a trimeric structure which facilitates the diffusion of maltodextrins across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an antiparallel  beta-barrel [1].	25.10	25.10	25.10	25.70	24.10	24.70	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.45	0.70	-5.38	6	1601	2012-10-03 17:14:36	2003-04-07 12:59:11	10	3	781	33	201	906	30	388.90	35	86.13	CHANGED	FHGYhRSGlGhousGutppshps.stt.....uhGRLGNEs-TYsElpLupElap-ssKoahh-oMVAhus..stpNDWE.......................sus.shRQhN...VQuKsLlsahPtuTlWAGKRaYQR.+DlHhlDFYahslSGs.GuGIENlclGsGKlSlAhlRp...stshT.ssss......phssslhDlRLAslthhssusLEluscYupAN....p+Dstshp..tsuKDGhMhouchTQulhsG.FNcaVlQYuT.uthutshGphhG............stoph.h.stthcssussaRllsaGshslG-sWpluashhYptupDhh.......usps........h-hhoVsVRPMYKWsshhpThhEsGYpsscspssu..t.-csst..YKlTLAQsWpsGsShWu..RPEIRlaATYhchDcc.sphtshs................stscDsEasFGsQhEsWW	....................................................................................FpGYhRSGh.G..h...s.u........s.......G.ut.pps...h....t...s.......t...............Shh.RLGNE.s-..sYhEL....pLs.Qc..la...p...-..s...s...+.o.h.h..hss...ls...hsl........p.t.p.ssWp...........................uss..s...h..+...p.hs...V...p...sKsh.....l...t.a.....h...P.tu.slWAGKRa.hp+...aDlHMlD.ahh.h.s.h...u.Gs....GuG.lENhc.l.G...G..Klul...Ahs.Rp......................st.s........s.....t.spp...............................phsss.shD....l...Rhssh.....t..h..........s.s....u......sL..p.lusc..Y.up..uN...........pp.D...s........p...s........h.s.t...K...D........u..a..hh...os.p..h.s....Q.s...h....h.....p...G..a.NcFsl....Qh..As....s....hh...u...ps..hGp.....tG...........................stst..h.s..t..........hshpssG..p.hhR...llsp...Gt....h..l.u.Dp.aphh.shh...Yp.p......Dh...........s.s.p.u........................h..c.hosslRPhY.tWs.shhpThhElG.Ypp.hcsp..p......s..s.....................scss...........YKhTLAppa....p..s..G..s.S.hhu..RPtIRh.a..AT...Yhchs-p...s..t.t..h..shs......................csss....D.pa..shG......sQhEhWW..........................................................................................................................	0	19	67	132
+3152	PF03746	LamB_YcsF		LamB/YcsF family	Bateman A	anon	COG1540	Family	This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression [1]. The exact molecular function of the proteins in this family is unknown.	22.00	22.00	22.20	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.48	0.70	-5.27	15	2484	2012-10-03 16:37:10	2003-04-07 12:59:11	11	7	2180	4	565	1717	1361	236.60	45	95.10	CHANGED	plDLNuDlGEuFGsaphGs..D-pllplloSANlACGFHAGDPssMccsVcLAtc+GVtIGAHPuYPDLhGFGRRshslospElhshllYQlGALpuhscupGsplpaVKPHGALYNphs+DcslAcAlscAVtshDssLhLhuLu...GSthlctAcchGLpshpEsFADRsYpsDGpLVPRupsuAllcDs-pslpQVLpMl+cGpVpulDGptlslpADolClHGDsPpALthsp+IRpsLcpt	.............plDLNuDLGE.....uaG.a...p...hGs.........DpplLslVoSANlACGFHAGD..spsMppTVch.AhcpG.........VuIGAHPuaPDltGFG...RRs.h.s.l.s.sc-lhs.slYQlGALpuhs...+upG..splpHVKPHGALYNtuAcDtplAcA...l.scA.l.t.s..........h.........D.........s....s.......LhLhGLu.......sS...t.l.lctAcp.h..G.L.tshpEsFADRuYpsD...G....o.....LV.sRppsGA.llcDp-pslppslpMlpcGp.Vp.ols.Gp.hl..s.l............pAc....o....lClHGDs.pAlthAcclRpsLtt.p....................	0	150	310	461
+3153	PF02061	Lambda_CIII		Lambda Phage CIII	Mian N, Bateman A	anon	IPR000278	Family	The CIII protein from bacteriophage lambda is an inhibitor of the FtsH peptidase [1].	25.70	25.70	25.80	26.90	25.30	25.60	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.02	0.72	-3.98	3	144	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	136	0	0	39	1	42.50	77	81.18	CHANGED	MpaAIAGuAVMGlupLsESLLERITRKLRAGWKRLlDILNQPGVP	....MpaAIAGuAVMGhspLsESLLERITRKLRsGWKRLh-ILNQPGVP.....	0	0	0	0
+3154	PF00052	Laminin_B	laminin_B; 	Laminin B (Domain IV)	Sonnhammer ELL	anon	Swissprot_feature_table	Family	\N	22.40	22.40	23.00	22.50	22.30	22.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.70	0.71	-4.56	9	950	2010-07-04 11:48:03	2003-04-07 12:59:11	13	274	91	0	537	928	1	133.20	26	8.37	CHANGED	YWthPppFLGcplhuYGGpLcaolpast....ss.sp.upsDVll+Gsslplss.hhspstsh..s-shhchhhplhEsh...aphpst..lo+cchhplLuNlstlLIRAoY.upchsthpLssVoL-hA..+.sst......sAs.VE	.........................................YWthP.t.paLGs.p.l.s.SYGG.pL.pasl..phps....................ps...p....pt......s.....D..V.lL...............p.G..s...............s..............hp.l...h.h.............p..p.......s.ts.......t...p....h.........p.......ph.....p.l..p.l.p.E.s.....t.h..........h.................p....ts................st....................loRp-hhtlLusLpslhI.....RAo.....Y...sst..........t.p..s..pLssVsL-sA...p.s.ss.s.......A..VE...............................	0	124	168	337
+3155	PF00053	Laminin_EGF		Laminin EGF-like (Domains III and V)	Sonnhammer ELL	anon	Swissprot_feature_table	Family	This family is like Pfam:PF00008 but has 8 conserved  cysteines instead of six.	21.00	13.40	21.00	13.40	20.90	13.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.90	0.72	-4.03	72	16492	2012-10-03 09:47:55	2003-04-07 12:59:11	19	919	252	15	9516	15120	36	49.50	30	19.94	CHANGED	CsCsspus.t.....spCc.............oGpC..Cp.sstGpcC-pCtsGaas.........sss.sC	..............................................CpC.s.st.u................tpCs.....................................................sG....p..C......h..C.........p.....t.....s..........s.t........G..t.....p.C.....-.....p.....C.t...s..G..aas.............................................	0	2235	2973	5910
+3156	PF00054	Laminin_G_1	laminin_G; Laminin_G; 	Laminin G domain	Sonnhammer ELL, Finn RD	anon	Swissprot_feature_table	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.66	0.71	-4.14	21	1504	2012-10-02 19:29:29	2003-04-07 12:59:11	18	398	102	34	720	7364	51	130.20	24	13.02	CHANGED	F+TpsssGllh..Ys.Gptsct.........DahultLhsG+lphphchGss....tssltsssp.lsDGpWHplplpRsp+pssLpVs.spp........................tspsshusss....Lshss..LalGG.hP......thtttthshssu.hpGCl+plhlssp.lp	...................................................................hpT.sss.Gllh........Yt...uppspt........................Da.h..u.l.t...L..h..........s....G....+.....l...ph..p..........a..c.........h.............G..ss.................ssh.l..t.....s.......s.......s.......h.....l......s......s..G..p..W.....H.....p..l......p......l........p........R.................p........p......p...............s.........s........l....p..V..s..s..tss.............................................................pt.ps..s.h.ssph...........ls.h..p.s.......la.l..G.G...hP....................h..h...t..t...t...h.....t......s....h..........s.........s.......s.....a.p.GClcpl..lstp.................................................................................................	1	123	175	377
+3157	PF00055	Laminin_N	laminin_Nterm;	Laminin N-terminal (Domain VI)	Sonnhammer ELL	anon	Swissprot_feature_table	Family	\N	19.50	19.50	20.00	20.00	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.71	0.70	-5.37	9	1311	2012-10-03 19:46:52	2003-04-07 12:59:11	12	174	102	7	725	1124	0	213.80	31	15.25	CHANGED	CaPAhsNLhhstp..lououTCGh+tPE.aClloclpt.....cKpCalCDuppsh.t....ppHhhphlscsps.tp..sWWQSp...NGl.....VTlpLDLcttFchTalIlpF+.T.RP.ushllERStDhG.sWtsYpYauhs...Ccsoastsspss.+p....s-llCTScYS-IpP.pcGEVhFpsL-..Puh...Ds.SPclQphlphTslRlpLsRL+TLGDsLhs.........c.clpc+YYYAIpDhsVtG	....................................................P.hhshh.st....l....s...s...sTCG............................s............p.......aCh..h...s...t.......................................pC....hCDu.p..p..................................sH.s.p..h.h..D.h.p.....s............saWQS......................p..s...h...................................pVsl......sLs..L..t.p.....tFcls.a.lhlp..Fp....osR....P.sshll-.+...........S.hD...hG....poWp.PaQYauts......Ctptas.......h.sp.s.s..h..p.......p...........p-sl...C......o.....s..p.a...S....c..h...P.h...p...s.G.....p........l....h...........aph.......l....s............t............P..u.h......p.........h.......-.......s.......SstLp...........-a..hpsTslRlph...h..R..h.p..s.......h...s...s.p.h...hs..........................................p...t.s.h.p..pY.aY.ult-h.VtG.....................................................................	0	151	209	445
+3158	PF01299	Lamp		Lysosome-associated membrane glycoprotein (Lamp)	Finn RD, Bateman A	anon	Prosite	Family	\N	31.40	31.40	31.80	31.40	31.00	31.20	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.12	0.70	-5.28	25	515	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	100	0	288	524	0	247.70	23	80.35	CHANGED	YslpphohsYNhoDsshFPsuospsstTssstss..lpuslssta+Csusoslphs.sVs.ph.ssplpAahpssshSppcshCppD...pss.Pss..............s.sssPuPo...hP..sPs.lGpYsVssu..NsT.CLLApMGLQLNlTYppt.ssppssplhNIsPNs.TsssGoCssp.pusLcL....sspshphLsFpFshssp...scaaLptVslshsl.....ssuss..hFsssNsoLshhpAslGpSYpCspEQslplosshp.......lNsFslpVQAFplsssp.FusspECphD-s.shLlPIs.....VGuALuGLlllVLlAYlIGR+Ro+u.GYQol	..............................................................................................................................................................................................................................s.s............................s.Ps.......s....pst...hsp..Y..plpss....st..s..Clhhph.ul.plplp...ap....p......s....t...............h...t.th..hs..ls.s...st.....sps..sG..sC...........t.....s........p....p....s.pLpL............s.t...p.h...h......h..L.....sh....tFs..........h.....s..s.....t................ppa...hL..pp.lplshsh..............ssstt....h...h.ps.t......s......p.s.....h.....p.....h....h...p.....ss.l....G....pSYtCst.....p..p..s...lpl......s.ssh.p..................lphhslp.lQ..s....F.....pl...p...ss....p..F.u.s.........s...p...c...C..s....hD......t.........t....s.............l...lP.lh.lGhsL.usllll...l.ll...u..Y....hl....tp......+pt.....Y....................................................................................................	0	98	117	186
+3159	PF05147	LANC_like		Lanthionine synthetase C-like protein	Moxon SJ, Finn RD, Fenech M	anon	Pfam-B_6095 (release 7.7)	Family	Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs [1]. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains [2]. This region contains seven internal repeats.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.52	0.70	-5.89	47	1539	2009-01-15 18:05:59	2003-04-07 12:59:11	8	21	836	8	490	1232	30	282.40	16	54.42	CHANGED	s.hshsLYsGhsGlulhhhphh..chhss.tp...hhph.spphlpphtpthppt............shohasGtuGlhhshthhsphhsp.pth.tphlpphhphh.pphtttt...............DlltGt..uGhlhhllhl.....p.h.tppph.....chlhphspplhpstpp..............p.hh.p......tsph...hGhAHGhuGlhhsLh.phhhp......hhtp...pphhchlcpslphhhphp..pp.ss...a.sthtpp...............stWCaGssGlhhsh.........hphtpsh.pcpphhcthtpshph.shp..ps....hhpshslCHGsuGsh.hhhhhtchhsppp..h.phtpph...hp.lhshtpp.h...........hstpss.spshuLhpGhuGhh..hhlhchhsspps.......sshhl	.........................................................................................................................t......h..G..Ghhhhh..h............t...........................h.th....h.t.h.....l.....pt.h.....ht............................thuhh......G..s..G..hh.h.h.hh..........h.h.........p.h......t.........p..........h....phhp....t.h....h....p..h...t...h..t......................................................-h.h.Gh...uGh...hhh...l..lhh............p.h...tptph............ph.lh.p..hh.pt...lh.t.th.t...............................................................t......hGhuHG..h......sGhhhhLh...h........................hht.........thh....ph.....lpthh...t....h...phh.......ttt..........h........t..................................................tWChGssGhhhhh.....................hht......h.....h...t...p................p....h..p..h...p....h.hp...hhp........tt...........hht.slCHG.sG....h..h.h...........h..h..p...........ht.t........h.....hh..t.h.................ht..h..h..t............t............................................................shh..G.sGhh...h.h.t..............................................................................................................	0	162	275	398
+3160	PF04738	Lant_dehyd_C		Lantibiotic dehydratase, C terminus	Kerrison ND	anon	DOMO:DM04916;	Family	Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides [1].  They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin.  Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues [2].  This family constitutes the C-terminus of the enzyme proposed to catalyse the dehydration step [2],[3].	19.80	19.80	20.10	19.80	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.54	0.70	-6.26	37	446	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	278	0	138	401	8	415.20	17	49.92	CHANGED	l....phscLlpplspphsshssptl..cphLppLlppphLlosLcsshssscsLpallstL................tshsttsp.hhptLpplpphltpasp..tshupttphhpplppphpplh........ss.....ps.LtsDhhhssp........lplspsltpphtpthphlhplssths...spt.thppa+ptFhc+Y..G.........sp.Vslh-hlssstGlGhP.sh...........shspttpcp.hthhtphhptslpsp.pclsLs-p..tlppltssss............h.sos-lhhplps...ptlppGphplhlsshh..tuh.susshGRFt...........tppppltpphtphhpsh.........sh.splshhstpt+stNVhps.phh....sphlsl.sptss.sp...ppltlsDlhVs....ssspplaLhshs.p...pphlh.hssshhsht...phPslhRFLh-lu....t...ht......hshtt.hpthsah....PRIpatchlls.t+Wplsst-lss.....thppatthht..pa+pphplPcplalt............psD.................phlhlDlcsshplplLtpplc.+psphpl	...................................................................................................................h..l..t.......t.h...thltpL...lppthlh....p...lp.s........pshphlhphl....................tttt...hhttlt.pltthht.....thtt...tt.stt..thhtpl..pthptlh...............................................................................pt.l.hDhhhsht....................lst.phh.p.p.l.t.t..hth..lh..hs.........t.t..hpthppt.F.h.c.+a..u.................tt.V..slhphhtt...hu..hshs..............................................t...t......h..ht....ph....h..t..s..ht.tt...tp.....l.lspt........lpthh.p.................h..ph-lhhthht................tt.....t.......p.hlhls.hh..hs....h..uthh.uR.Ft.....................................tph..t..t....h...tp..tt.............s..spl...s.h.s......p.ttNl.htp.....h.....th.lsh..tt.ss...t...........ttl.lsDlhls....sp..ttpl.hlhs.p..h....sp..lh.h.....sh..hs............s.hh+.hLhpls..........................................h......h......tths....ah............P....Rlph.t.p.lllp.tpWplstt..tlsh..............p.t.......htth.....h.t...pappph..p..lP....phlhlh..................ttc..............................p.lhlshppshphthlhpthp.p......................................................................................................	1	60	101	119
+3161	PF04737	Lant_dehyd_N		Lantibiotic dehydratase, N terminus	Kerrison ND	anon	DOMO:DM04916;	Family	Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides [1].  They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin.  Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues [2].  This family constitutes the N-terminus of the enzyme proposed to catalyse the dehydration step [2],[3].	22.80	22.80	23.20	23.70	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.20	0.72	-3.97	38	378	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	260	0	115	326	3	93.90	23	10.55	CHANGED	hp-AlhhuSssLhppltp.......htss....hps+chRphtpulhpYlhRhssRsTPFGhFuulshGpa......sppsss.phsssp..+ppsphDhtaltplspplcp	.......................pEulhhuossLhpslpp.................htts......hps+c..h+.p..hppolhcYhhRhssRsTPFGhFuuluhuph............ssps...sh........ph..s..ssh......ppts..ph-ttalhplsphlt.t...............................	0	47	82	100
+3162	PF00500	Late_protein_L1	late_protein_L1; 	L1 (late) protein	Finn RD	anon	Pfam-B_69 (release 1.0)	Domain	\N	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.57	0.70	-5.96	19	3438	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	304	77	0	2486	0	179.90	45	98.21	CHANGED	lWhPupsKVYLPPs.PVo+VlsTD-YVsRTsIaYHAuSsRLLTVGHPYaslppss.....p+hsVPKVSu.QYRVFRl+LPDPN+FuLPDpslaNP-pERLVWAstGlElGRGQPLGVGloGHPhaNKh-DsENssthtssstp......DsRpsluhDsKQTQLhIlGCsPslGEHWspupsCssstsp..G-.CPPlELhNosIpDGDMsDhGFGAMsFpsLQusKSDVPLDIssolCKYPDYL+Mus-sYGDSMFFahRREQhasRHaasRAG..ssG-slPsshYlcu..........t.....psshuoslYhsTPSGSlVoSDuQLFN+PYWLQRAQGpNNGICWsNQLFVTVVDsTRuTNhoIsssspss.....ssYssocF+cYlRHsEEY-LpFIhQLCKlsLTsEshuYlHsMssoILEsWphGlsPPPsssLEDpYRalpS..AhpC.cssPPpcpcDPYpch+FW-VDLpE+hSh-LDQFPLGRKFLhQsGlpppsphpspphp..sssssssppssKR+R	.......................................................................................................................................................................................................................................................................................................................................................................................................................................hDsTRSTNh.olssthpst..........ssYpss...paKcYhRHs.EEa-LpFl.FQLCplsLss-lhshlpsMssslL-sWphGh...s..s..ssssl.DpYRalpS..AhtC................................................................................................................................	1	0	0	0
+3163	PF00513	Late_protein_L2	late_protein_L2; 	Late Protein L2	Finn RD	anon	Pfam-B_39 (release 1.0)	Family	\N	20.40	20.40	20.50	21.80	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.66	0.70	-5.63	29	499	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	258	0	0	495	0	460.80	41	97.13	CHANGED	R...s+RpKRASATpLYpTCKtuGTCPPDVIsKVEtoTlAD+ILpaGSlGVFFGGLGIGTGuGoGGRTGYlPLG.....tsshssssssssRPPlllE...........sVuPoDPSIVSLlE-ou.....................hIpuGAshsshssss...GFslToSus...sTPAlLDlo....ssspoh.losTpapNPsFs-Pohlpsst.suEsoG+lllS....ssTluscs............hEEIPhcTFss.ss..ss.sshSSTPlPssppsst.t...LYoRshQQ.VpVsDPsFLopPpc....LlTaDNPAFEs.p..sTLhFpps...hptsPDsDFhDIltLHRPAlTo.RcGtVRhSRLGp+uThpTRSGppIGARVHaYpDlSsIsst.......-tIELpsLsttussss.............psuLaDlYs-.....sss.s..........hhpss.h.....pshsss.ss.ss.sspssNsTlPhspshcssh.sGPDlsh......Psss..sssshhPhsPshPshsIhlpGs....DFYL+PShahh...+RRKRlsh	....................upRpKRASATpLYpT..CKtuG.TCPPDVIsKVEtsTlADpILpaGShGVFFGGLGIG.TGu.G...T.GG.R..T........G...Y...l.PLGs........pssp.s..sss..........s.......s...ss......R.P....P...l..s.l-...................................sVuPs..DP..SIVo..LlE-.ou.......................................hI-uG.A.s.ssshssss.........GFs.lo...o....oss.........sTPAlLDls..........................sss..p..s......h...oso.s....apN...PsF...s...-.P...ol...l...p...sst....su-s.u...G.clhlo...................ssol.uscs.......................aEEIPh....cT.....F..h..s...........ps........ss............sspSST.P...l...Ps.s...c..t.s....s...pht.............LYuR.....s.h.Q.........Q.............VpV........sD.P.sFLop.Psp....llT..a..D..NPAaEs....sTLhFpps....h.p..APDPDF.h..DI..ltL.HRP.A...lTo..RcGs.VRhSRlG.p+.uT.l+TRSGppIGA+VHaYpDlSsIsss................Ep..IELQsLss.....s.ssss.........h.................pssl..aD...lYu.-s....s.......s.p...............t..h......s.ssst......shs......s.sp.p...s.s..ss...T...l.Phs.s..s.h.s...ss.l...h.s..G..PDlsh..........................ssss.....sssshh...Ph.s...P.....h.....s...Pth....s...l..h.lpuu........DFaLHPShhhh...++RKRh...................................................................................................................................................	1	0	0	0
+3164	PF02354	Latrophilin		Latrophilin Cytoplasmic C-terminal region	Bashton M, Bateman A	anon	Pfam-B_874 (release 5.2)	Family	This family consists of the cytoplasmic C-terminal region in  latrophilin.  Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin  family of G-protein coupled receptors that are involved in  secretion [1].  Latrophilin mRNA is present only in neuronal  tissue [1].  Lactrophillin interacts with G-alpha O [1].	19.30	19.30	69.20	20.30	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.07	0.70	-5.74	3	436	2009-01-15 18:05:59	2003-04-07 12:59:11	11	23	39	0	132	329	0	235.30	47	23.71	CHANGED	RHhHCCShhPpG..RSol.ESopcoGupSGSGsPhpauh.oQSRIRRMWNDTVRKQSESSFIoGDINSTuTLNRGsMGNHLLTNPLLRPHGTNNPYNTLLAEoVVCNsPSsPVFNSPGuhhp..HsL.NuRDTSuMDTLPLNGNFNNSYSLRSGDY..uDGVQllDRGhNLND.TAFEKMIISELVHN......NLRGtSucs+ss.hchPVsPVsG..uSEDDAIVsDuAo...HtDssGLELlHKELEAPLLPPRsaSl....LYQss.....p....DcSESasupLTAEucEcLQSPsRDSLYTSMPNLRDSPoYP-SSP-s.sEsLsPPPPAcsGssE.IYYKSM.PNLGARN...QLQsYYQluRGSSDGYIlPPNKEGssPEG..D...GQMQLVTSL	..................................................+oaCC.....t...+uo..tSsht.ostp...sot...................................oQSRIRRMWNDTVRKQoESSF.hsGDIN...........SosoLNp.........t..............................................................................ss..R-sssMDTL...PLNGNas.NSYSlttspa........tss...s..t..s......h....s.ht-.sshEKhIlpELspN.......N.+........t.t.......................................................h.....s.......................st...cpp..............s..hh.st.........................tt........tlEhh.....h.....p.t..ptPLl....R.....s..s.....................................................ttsto.hs..s..t...............t........t...............................ss....tRDSLYsShs.Lts.s.........................t.........-........................p..Yh.uh.PtLsst.........hYph......t.pG.......-.....s-t.........t...phlTSL..........................	1	4	16	60
+3165	PF01273	LBP_BPI_CETP	Lipid_binding_gp; 	LBP / BPI / CETP family, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.	28.30	28.30	28.80	28.30	28.10	28.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.85	0.71	-4.90	36	774	2009-01-15 18:05:59	2003-04-07 12:59:11	20	9	110	3	412	720	0	166.10	17	38.69	CHANGED	uLphssp.uh..h.t.Lpplsls-hhssht.t..u....................th.hshhslcIpshplsp.hplchhssssh.hhsth......ssslplps..ph.hh......t.shlcl.........shslslpsplpltp-sp.GcsplshusCssshsslplpl.ss.....hshlhshhpshlppsltpllpsp....lCsll.....psh...Lpsl	.................................................................l..h..t.sh..htpt.l.p.p.hplsshhsp..s....h...........................ph.hslpsl..plpphplsp..splph.hsstth.hh.h...............ssslslps....phtht.............t.thlch.................hhslslssplpltpssp.Gpspls.h.s...sCsspls.......p...lplphtss.....hshlhph.h..p.s....h...lpp...sl....pp....hlpsp........lC.hl........sth...h.................................................	0	64	88	182
+3166	PF02886	LBP_BPI_CETP_C	Lipid_binding_gp; 	LBP / BPI / CETP family, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.	20.60	20.60	20.60	20.60	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.42	0.70	-5.14	10	709	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	111	3	395	669	0	211.60	20	46.01	CHANGED	ssLDlhhK......G....EFFshsc+sPsshsssshslP..pscsRMVYhulSDahFNoAshsYacuGaLpholssDhlPs-sslR...Lso.....psFushlPpLActaPshslcLpssssssPhlshpss.slslpsshslpsallh..Psu.s+pslaplshssssosslohpsc+lsGpLchc+lplcLpcSclG.hssEhlpul.LNhhlsshlhPtlN-+Lt+GFPLPLP.ctlpL..aclt...LpsHcsFLhlGADlpa	................................................................................................................................tpppMlhhhlS-ahhs...ohhhhh.p..s..Ghlphsl...s.s.p..ls..p............hh..........so.............................pshu.hlsp.l....s.p..t.a.P.s....t.s.h..lpl...p.s..s.p.s......P.h..ls.......hpss...sss..l..p..ht..ss.l.p.hhsh.......s......ss...s............tsl...............hplshs..s.s......h..ss.p....h.s.h..p....s.....p.......+....L..h.s...p....l.p.l..p.p..h.p..l...p.......h..tp.S..........pl.s...h..s....h.t....l.p.sh...lp.hlphsh...hP..hlN..t..h..L.....t.....tGhs.lPh.....ts....lph....hs......l...hhpshlhlt..................................................	0	92	125	231
+3167	PF03815	LCCL		LCCL domain	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Domain	\N	22.60	22.60	22.60	23.40	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.47	0.72	-4.00	68	852	2012-10-01 19:31:27	2003-04-07 12:59:11	14	48	198	1	528	762	11	100.40	30	19.17	CHANGED	lsCpsphtpht..........h....hssphhhpCPssC..tpst...splhGot......................lYsssSSICpAAlHuGll.................sspGGplslphhsshppYhuo..p....pNGlpS...tsh..t....tpuF	........................................................pC.sph.p.t.................ssp.hthpCPusC..tpsp...............splh..Got..................................................hYp.s..sSolCpAAlHuGVl.................sspG.G.tlsVt.h..h...s.s..p..p.p..Yh.uS......h....pNGlpS....sh...............................	0	140	228	365
+3168	PF04072	LCM		Leucine carboxyl methyltransferase	Wood V, Finn RD	anon	Pfam-B_5898 (release 7.3);	Family	Family of leucine carboxyl methyltransferases EC:2.1.1.- . This family may need divides a the full alignment contains a significantly shorter mouse sequence.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.09	0.71	-4.72	211	3171	2012-10-10 17:06:42	2003-04-07 12:59:11	9	48	1290	36	972	2545	132	173.20	26	52.57	CHANGED	AlhsshsRAhcspt.s...ssllpDshAttllpsh.......................phshtt..............h.thttt...hs.sRs+ahDchhtpth..tsG...htQlVlLuuGLDoRuaRls..t.........ssplaElDhPpllphKpphLspt.sp.....................s...hh.h..lssDlp..psWhssLttt..Gap.ssp..........P...shalsEG.llhYLst-shppLlppls	.......................................................................................hhshhtRAhtspt.s.............psllp..DshAt.hlpth............................................................th..tt....................ht.t.h.t.tt......hs..sR...sphhDp....hhtphh..........tss.....................htQlVhLuuGLDo......R......sa.RL.s.............................tsp.ha.E.....lDh..P.p.ll.phKpphltp...t.tt.p.........................................................................................t..thc..h.........lssDl....p...t....p......s....W.....s..s....L.ptt......shc..sst.............................P......shhluEGl.lh.YLstp.t.ppLlptl..........................................................................	0	293	586	821
+3169	PF04792	LcrV		V antigen (LcrV) protein	Waterfield DI, Finn RD	anon	Pfam-B_6155 (release 7.5)	Family	Yersinia pestis, the aetiologic agent of plague, secretes a set of environmentally regulated, plasmid pCD1-encoded virulence proteins termed Yops and V antigen (LcrV) by a type III secretion mechanism. LcrV is a multifunctional protein that has been shown to act at the level of secretion control by binding the Ysc inner-gate protein LcrG and to modulate the host immune response by altering cytokine production.  LcrV is also necessary for full induction of low-calcium response (LCR) stimulon virulence gene transcription.  Family members are not confined to Yersinia pestis [1,2].   	25.00	25.00	61.00	41.50	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.84	0.70	-5.40	2	127	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	82	1	10	81	0	260.30	49	80.26	CHANGED	.lRshpts.phFl--L....ltt.su.uSu..EELltLl+scpIsluhthpPhp-upV....................L.t.AhLhuup.ss..tpGlchl+EhLpu..pPssQW-LRtFhsshaFSLpu.RlD-DlltVhhDshpppsstRptLh-ELttLTAELKlYSVIQupINttLSuttsIpIcstuIsLhD.sLYGYs.s-.haKsSsEYtlLpph........-T.pthlSIKsFLpup.KpoGtLtsLpDpYsapKDNN.lupFATTsSD+SRPLNDhVspKTT.LsDhoSRaNSAlEALNRFIQKYDSVhpclLssh	................................................................................................l.shpts.thFlt.L....ltt.su.tss..pELltLl+scpIslu.ht.pPhp-.ups........................L.t.Ahl.u....up.ss..ttG....lthl+phLps.....pPs.spWpl..RtFhslhh.SLpuDRlD-Dlltshs-shsp+sstRppL+-ELt-LTAELKIYSVIQucINptLSs...sus...hphcspuhN....LhDhsLYGYs.s-thF..Ks.....SsEYKlLpch.............t.........spppl.lolKsFLtupsKpo...Gsluslcs.pYpapKDN.NcLupFuTosSD+SRPLND.VspKTTpLsDloSRaNSAlEALNRFIQKYDSlhpclLssh.............................	0	1	3	4
+3170	PF00056	Ldh_1_N	ldh; 	lactate/malate dehydrogenase, NAD binding domain	Bateman A, Eddy SR, Griffiths-Jones SR	anon	Overington enriched	Family	L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family.  Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.60	0.71	-4.36	31	12983	2012-10-10 17:06:42	2003-04-07 12:59:11	18	15	8382	421	2210	8108	2565	125.70	35	47.64	CHANGED	hKVullGA.GtVGpuhAhtlhtp.slucE..........LsLlDlspp..tscGsAhDLpHusshs.ssshlss...sshsshcsuDlVllsAGsspKPG.o.....RhDLlptNspIh+slssslscsu..ssuhllVloNPVD....IhshlhhKhushspp+lhG	.............................................pl.lhGs.G.lG...........sh.............h......h..h.t........s.t...................l.l....h-.....h.............hh.G.s....h.-.....ltc.....h...........................h..................h.................p..............s........h...................s...........s..........t..........s......sh......ssh.c.sADl.Vl...l...o..A.....G....s....s......R....K......P......G..M..s....................Rt.........D.L..h..s....h....NstI...h....Kslsppls.p.s...s........ssu...h.ll.l.l.oN.P...Vs....lhs.l.h.p.Kh.u...s..hspp+lhG................................................................	0	689	1286	1790
+3171	PF02615	Ldh_2	ldh_2;	Malate/L-lactate dehydrogenase	Bashton M, Bateman A	anon	COG2055	Family	This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyses  the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyses the reactions: (S)-malate + NAD(+) <=> oxaloacetate  + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	21.50	21.50	21.90	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.82	0.70	-5.72	8	2631	2009-09-11 11:09:40	2003-04-07 12:59:11	9	4	1423	44	609	1711	3069	322.80	31	94.97	CHANGED	M+lshEpL+phIpcVLpphGlsEEcAchVADshlcADL+GhpSHGlsRhPpYlppLppGsIsscsch+hlcpususullDGDcuhGpVsA++uM-hAI-pA+ppGVGlVul+NuNHaGtuGYYuppAAcpGhIGIshTNoc..PhVsPaGG+EshlGTNPlAlAhPupc..hhhlDMATSshAaGKlhsARc+GcpIP-ssulDc-GssTTDPshlhcs.t..lLPhG.......GaKGYGLSlhlDlLuGlLuGushuspVopssss.--tsspsplaIAIsP-hFhss-pFcp+lsphh-ElKuSp.usthpplhlPG-hpshphccpp+pGIslDcslappLpsl	..................................lshppL+p.hhpplLpp.tGhspppApt..lA-hLltAshpGh..pSH.Gl...s...Rl.st..Yl.pplppGt.lp..s.s.p...s.plh.p.p.s.su..h..shlDucpuhGplsuctuMstAI-....h....A.cppG.luhVul+...s.u.s.HhGthuhaspp.sAc.tG.hl.........u..l.shs....s..os....sh...lsP.aGGp-shhGTNPlshu..hP.........s................p......s.........t.....shllDhATSshAhGKlpssp..ppG..c..p.lPs.shulD.p.p.G..p.s.......T...sDP....t.....s....h..................p..s..h.............h...L.P.h.G.........................taK.G.GLuh....hl-lLuGsL.s.Gu.s..h...s..t.......p.......l........s.....p...........h...s.....s.......t.ps...t..h.....s..phhI.s.IcPshF....s..s.....t..t..h.p..tc..hp.p.hhchlpsst....ts..s..p.tlhhPG.c.p.htt.t.p.c.s.t.p.p.G.I.slssshathl...t......................................................	0	183	341	493
+3172	PF02866	Ldh_1_C	ldh_C; 	lactate/malate dehydrogenase, alpha/beta C-terminal domain	Bateman A, Eddy SR, Griffiths-Jones SR	anon	Overington enriched	Domain	L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family.  Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.	22.60	22.60	22.70	22.70	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-4.53	19	12166	2012-10-02 13:39:36	2003-04-07 12:59:11	13	14	7571	421	2231	7218	2555	135.60	32	49.53	CHANGED	TpLDpsRupsh...........lAc...ttsl.sPpsl...pVhllGsHus..........lshlPl.p.sp..sphs.cpplpplhpplppuGscllctKt..GSsshShAhAhs+....hscullpsh......pshh.huVhpsu..husps....................haauhPlhlstsG.....lpcl.l-.hs.Ls-hEccthp.putspLcpplcpuhphh	................................TsLDssRhcsh.................lA-...............hhsh..ss.ps.l............cs.llGsHu...........s...................................V........s.......h........l.......P.......L....h....s........l....p...............................t.........s.....t.....t.....h.....t...tl....h.t.....p..h..tp..t.u...hpl....lph.+.................sus........hu..h..u.uhhp.................hsp...sh..h.ts.................................pt........hus.h....p.......u........ht.......t...........................hhhu.Pshls...p.G.......h.ph....hp.......h.....l..s.t..p..tt..ht...t.h...t.l.t.........h.......................................................	0	697	1291	1800
+3173	PF00058	Ldl_recept_b	ldl_recept_b; 	Low-density lipoprotein receptor repeat class B	Bateman A, Sonnhammer ELL	anon	Swiss-Prot	Repeat	This domain is also known as the YWTD motif after the most conserved region of the repeat.  The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.77	0.72	-3.63	28	8618	2012-10-05 17:30:42	2003-04-07 12:59:11	12	734	140	112	4691	7279	7	41.70	31	14.93	CHANGED	splYWoDhs.p.....sluhsshsGss..pcsllspc........lppPpuIslDh	.............tplYWo..D.hs.pp.............pIc.pu...s.h...c....Gsp........Rps.l..l..sss............lsp.Pp..ulslD....................	0	963	1312	2717
+3174	PF03760	LEA_1	LEA-group1; 	Late embryogenesis abundant (LEA) group 1 	Finn RD	anon	Pfam-B_1549 (release 7.0)	Family	Family members are conserved along the entire coding region,  especially within the hydrophobic internal 20 amino acid motif, which may be repeated.	25.00	25.00	26.10	26.10	22.70	21.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.55	0.72	-3.83	8	153	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	36	0	41	142	0	71.70	43	51.71	CHANGED	MQSuKEKhoNhASoAKEph-lsKAKs-EKAEKuTARoctE+clAHp+cKAKEApAcM-hHpAKAcHAA-K.ps	.........hpohKEpspNhuuuAKtth-hsKAplpEKAEKhTARs.hcKclAcc++cAKhspAch-h+pA+tcpsAtK.t.t........	0	3	22	34
+3175	PF03168	LEA_2		Late embryogenesis abundant protein	Mifsud W, Griffiths-Jones SR	anon	Pfam-B_3080 (release 6.5)	Family	Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress.  The function of these proteins is unknown.  This family represents a group of LEA proteins that appear to be distinct from those in Pfam:PF02987. The family DUF1511, Pfam:PF07427, has now been merged into this family.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.19	0.72	-3.63	144	1601	2009-09-13 08:28:33	2003-04-07 12:59:11	8	14	422	3	862	1521	41	100.30	16	47.34	CHANGED	plplpN.PNs.hs.lsh.ssls...hslt..h.....su....ptlu..t.us.spshplsspups....hlsl..s.....lplshts.h.........hphhtshh...........hstplshplcuplp.h.h.h.hthsl.shspps	....................lplpN..PNp..hs.lhh..sshs......hplh..h.........ps............ptlu.........ssthssht.h.stp.s.ss..............slsl......s..............lsls..sht.h..................spth..t..s..hh....tt..................hshplphplcs....chp......hh..h..hphph..ht..................................................	0	152	498	703
+3176	PF03242	LEA_3		Late embryogenesis abundant protein	Bateman A	anon	Pfam-B_3170 (release 6.5)	Family	Members of this family are similar to late embryogenesis abundant proteins.\	   Members of the family have been isolated in a number of different screens.  However, the molecular function of these proteins remains obscure.	21.00	21.00	21.40	21.00	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.54	0.72	-3.74	13	167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	52	0	57	159	0	86.70	32	82.53	CHANGED	MARSlo.suKhlSAhlsDslSsh.hpRRGYAAAust..hsu.....hRuGustsss.hts+suEs.....sstssuWsPDPVTGYYRPEspusEIDsAELRphLLs	...................................................................................t.h................ppRuYuA....uAst...httu.........ts.us.s.tphs.......tt..scssts..............spcpssWhPDPsTGaYtPEs.phsE.lD.sAELRttlLp.........	0	7	30	43
+3177	PF00059	Lectin_C	lectin_c; 	Lectin C-type domain	Sonnhammer ELL, Griffiths-Jones SR, Eberhardt R	anon	Swissprot_feature_table	Domain	This family includes both long and short form C-type	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.85	0.72	-3.39	95	12227	2012-10-02 16:37:33	2003-04-07 12:59:11	16	665	521	504	7014	11645	360	107.50	20	30.77	CHANGED	pthsapcApthCp.p...hsupLsshps....tpchchlpphh...........sspphWlGl.......ttpptsapW.sssshp...........................spsspsppCshl............sssphss......psCsp.tphhlCcp	.......................................................................................t..hsappA..p.p.hCp..p............ts....u..p.L.s.s..lps.....................pp.E..p..p...a....l.tp.hht................................tppthW.....l.GL..................pptppps...p......a.p.W.s..D.u...s..s.h..s............................................h.tW..........................sst.ssspsCshh.................................ttsspW.ps..............................ts..C......p....p....p......h.........a..lCp...........................................................................................................	0	2294	3027	5110
+3178	PF03041	Baculo_LEF-2	lef-2; 	lef-2	Bateman A	anon	Pfam-B_1773 (release 6.4)	Family	The lef-2 gene (for late expression factor 2) from baculovirus is required for expression of late genes. This gene has been shown to be specifically required for expression from the vp39 and polh promoters [1].  LEF-1 is a DNA primase and there is some evidence to suggest that LEF-2 may bind to both DNA and LEF-1 [3].	25.00	25.00	60.10	58.10	20.00	19.50	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.22	0.71	-4.57	11	69	2012-10-01 20:20:07	2003-04-07 12:59:11	9	1	62	0	0	68	0	164.60	35	79.78	CHANGED	ph.lhapP...tpsIDcstpYlVchpsas..lslosYTsFppsGLhVhlsGhpLhpLlcsssstppssssp.........tpp+sp+NVCFpssss.s+psllshLpsplp...hPsChpphhpclpsp..PRssRaRKRFlFNsYlsNsloCs+Csp.pClhcAhphhYptDpKCVpElpp	.........h..hWsP..ht..t..sslDK.sts.YhlchpDa...lsloPYTsFhpsG.hhlclsGhR.Lhh...Llpssss.ppp.psst..................hhc+Sp+NVCFpsstp.t+psllchlppplp....hPsC....hpph.hssLp..hp..PRGsRa+KRFlFNsYIuNlloCsKCcp.pClhcAltthYppDsKCVpElp...	0	0	0	0
+3179	PF03388	Lectin_leg-like		Legume-like lectin family	Mifsud W	anon	Pfam-B_2789 (release 6.6)	Family	Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 Swiss:P49256 and ERGIC-53 Swiss:P49257 lectins. These two proteins were the first recognised members of a family of animal lectins similar (19-24%) to the leguminous plant lectins [1]. The alignment for this family aligns residues lying towards the N-terminus, where the similarity of VIP36 and ERGIC-53 is greatest. However, while Fiedler and Simons [1] identified these proteins as a new family of animal lectins, our alignment also includes yeast sequences. ERGIC-53 is a 53kD protein, localised to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC). It was identified as a calcium-dependent, mannose-specific lectin [2]. Its dysfunction has been associated with combined factors V and VIII deficiency OMIM:227300 OMIM:601567, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein- secreting pathway [2,3]. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.52	0.70	-5.24	8	783	2012-10-02 19:29:29	2003-04-07 12:59:11	8	10	280	35	470	811	29	200.80	27	52.53	CHANGED	cpacpcaSLhtPahspupsslP.hWcatGsshlo.SstIRLTsc...pSppGulWs+psshh.csWElclsF+VsGptt.pltuDGlAlWYTp-psh..sGPVFGusDpasGLuIhlDoasNcsss.p+spPalsuhlNDGohpYDHscDGspspLAu....Cpt.cFRNp-asoplpl+YspshLolhh-.s.lcsps-achChplssVpLPsGhY.FGlSAsTGsLuDsHDlhShhhhplps	........................................h......hoh..P...h....s.......s.....tt.h....s.hWph.tG..s..s...h...h........p.....s....p......h...l.RLTssh.........ps.p.p.G........s.l.Ws..c.sh.................h...p......sWc...l...............clp..F+l.........p.........Gp............t....ph...t..u...D..G.hAlW...h.sp......ppht.............G......s......l....a...G.s...s.....pa.pG.....l....ulhh......Do....a...Np............t....................................t.....hP..h...lps....hhN....s......G..s..h...p..Y-p...ppD...G....p..t..p...t....l..uu.......Cph.........t....h.....R........s...t...s.....h...s.........o....phpl..pY.h..p..t.....h...p..l.................h.....s.............h....p......sp...tp......a.p..........Chp.s....p.....s.....l...t...l.....P......p.....s......h......a.....hGhS..At.TG.......s.L......u.D........sHDllphhhht.............................................................................................................	0	158	234	362
+3180	PF00139	Lectin_legB	lectin_legB; 	Legume lectin domain	Sonnhammer ELL, Bateman A	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.90	0.70	-5.00	47	1651	2012-10-02 19:29:29	2003-04-07 12:59:11	14	73	320	724	782	1765	72	204.20	27	39.67	CHANGED	ssspFsa........ssF......st......ssLhLpGsApl........ssGhLp.LT.......sssp.......pshG+AhYs.pPlpl...hssssup....h.......sSF.sToFsFsI..h....ssssucGlsFhluPss....ssu..sutaLGLhNtpsss......sspllAVEFDTht...php-hDs....NHlGIDlNSlpSsto...sh................tshsLsu...GpshplaIsYcussppLsVslu.s..p.............cPpp.sllStsl.DLss.lls..-......psaVGFSAuT.G........hsptHhlLuWSFs	..................................................................................t...a.h........t.a......tt.........ts.l....h...Gs..A..h.........ss..s.h.lp..LT.....pst.....................tthG+shas.tP.lph............hp.........s..s..t..........h......................tuF.so...pFsFs.l....................................t........s............suc...........G....huFhls..sst.......sh.sts......suth...L....G...l..hst......p....stt.....................psphlAV...EF...DT.hh................t.....t..c.hss...............sH.l.G..l...D..l.......N......u....l..h.S....h..t..s...........................................hsh.s.lt.s......up.......hpshlsYsu.s.s.....p.......hLsVsls.....t...........................pspp.....h..lo.h....l.....sL...ps...h.l.s....-.............shlGF....SuuT..G.......thh.pt..p.lhuWsF.............................................	1	114	409	591
+3181	PF03954	Lectin_N	lectin_N; 	Hepatic lectin, N-terminal domain	Finn RD	anon	DOMO_DM01961	Family	\N	25.80	25.80	26.50	25.90	25.20	25.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.54	0.71	-4.77	5	128	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	27	0	61	131	1	121.20	43	48.84	CHANGED	pchpHLpNs.p-c+shcKGPPPoQPLLQRLCSssRLLLLSLuLSILLLVVVCVIGSQN.....SQLQEELRoLRETFSNFTSSTcsEVpALST........................pGGSVGcKlTSLESpLEKQQQDLKsDHSoLLhHVKQFssDLRoLoCQMAsL	......................................s...ptp....tG.....sPs.ps.h.hpR.LpShspL.LLuLuhslLLLV.llCVlGSQs............upLpc-LtsL+psFSNFous...ThsE.lpuLso........................pG.uu..lscKlpSLEupLEKppQ-Lps......cp..SplhhHlpphs.DL+.LsCQhs.h............................	0	4	4	10
+3182	PF05098	LEF-4		Late expression factor 4 (LEF-4)	Moxon SJ	anon	Pfam-B_6330 (release 7.7)	Family	Late expression factor 4 (LEF-4) is one of the Baculovirus late expression factor proteins. LEF-4 carries out all the enzymatic functions related to  mRNA capping [1].	20.20	20.20	20.60	22.10	17.80	20.00	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.78	0.70	-5.73	25	64	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	60	0	0	63	0	434.20	40	97.95	CHANGED	EpEISYTINaSQDLLYlIhcoYIsK+h.pht-cYsDllDpNsVRTRlhs................sphsSV+Kpslshp+hVah..sssslVPhVsRcshEpsssssspp......l+RllcspVY+...tpsslEIKFEHlYappNhsDphDuLhAsKQIsLaNLLpspsp..slspNSHLGSDEILAslRLEhEYc..sssstssLpphscllsch-.slstppNIoPhLPYTTLhNpIhYRKFpcE+.hl.....hs.t......t.ssssVh+WAlKLDGlRG+Gahs+s.hhll.hDDMQhFSGpl.......................................ss.FslNNlVuFQCEll-..pslYlTDlLpVFKYpYNNRsQYEsSh.psYsl-shsAlpslNhh........sssssphslssh.tst..hpl+FQpFacPPlphst....YsolPsDGFVVLDsphpYVKYKphKTlElEY-spsstFpslpGslpspshhss......Lp+ssIYEsllsc...ssIpVlKpRPDRLVPN	....................................................EpEISYoINhSQDL...LYhIhcoYIs.cph..phtpcYsDlhDpNslRTRl.s................sph.sSVpKpshphc+hVah..spsslVPhVpRcshEpshspsshp......l++llcspVY+......psplEIKFEHlYhppshh..Dp..hDuLhAsKQls....LhNLLpsssp.....sl.hpNSpLGSDEILAslRLEhEY-t...sssst.....shLpt..........hs....plltph-.slsptp.NIs..PhlsaTTl.NpIhYRKFtcEphl..hs.t...........t.sssslh+WAlKLDGlRG+Ghhsps....h.............h.............ll.hDDMQhFuupl.......................................ss..F.slNNl.VuFQCEllst.pphYlTDlLpVFKYpYNNRTQYEsSl.ssYslsshsAlpslNhh.........ppss.pplslpsh....s.thpl+FQpFacsPlp.st...........YsolPsDGaVVLssphpYVKYKhhKThElEYsstsshFpslsGslpshplhss......Lp+ssIYEsllsc...ssl.pVlKpRsDRlVPN....	0	0	0	0
+3183	PF04941	LEF-8		Late expression factor 8 (LEF-8)	Moxon SJ	anon	Pfam-B_5130 (release 7.6)	Family	Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to the  second largest subunit of prokaryotic DNA-directed RNA polymerase[1].	17.60	17.60	57.60	20.40	15.10	14.80	hmmbuild  -o /dev/null HMM SEED	748	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.32	0.70	-6.86	7	329	2012-10-01 19:23:01	2003-04-07 12:59:11	7	2	143	0	0	243	2	320.40	47	92.17	CHANGED	VlpDFscLYcplcsp.asLcahLsCss.puss.sol+hLQERKSYFCCAlc.sht+CVLHKCVlVVFGThLDtpFRss-......................sspsslpGTFMlDGRaLSFPNIMMNNNlLlHNFYDKLYu..KsCKRMFLYGNlD-EKpINRAIQLVYDctpDlLFARDVYApDYVVT--LNplLEhYLpsSGKWcPLsFLFcasptps.pLV-pIKhIMpt-INYSIDSLuNKIIYKHsYLlpLlY.cslLptYpt.htps.s...............s.sstsK++Ks.QolhasKEsKKIVDoIVNG+LIYsVSKTFSKQKKsF.N.QDNSSNNNIEIs.PsLKYRlGNEVlRITNDoMRQDMLKQchDFVKFlDSFFHGEMTVAGKKFFLCRsVRLPsVDYphVAc+FppLlppsLlhhss...........cp..........s-stDs.LLIAFNsRPTshpCcRsclspIhYthKRNhsPlElKlsssILFVNHHEGMlCIKKpV+lss....lpIssLLTPYEYHNppSllpshs...spl.EpDcVssLMSKLlQYYYpsahplFsTlPVPKLIVSLTNLKNAMPVhpYss.......t..lssLPlGNSVsVuPclhhNNKMFpLWTLVRDs+LMTAEDPYIPchsLPI+LYNNKlNKLKGKLshupp.psPhlKFh.pS.spsNhVslpsGpVLhhsGVlVSNsKIsWsaDGKRYKIETCpNKsaaVYKIYlYaRplcsQ+lE+lcuphsstsDsValKlslVTSTssLcGlKICGIHGQKGVhNsuEDLTEWMAEDG	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VAGKKFFLCRsspLPsVDYphVApKFp.LlppsLlhhss...........s......................................p.sp..cs.tllIAFNsRPThhpCp+.ssl.hIhYphKRNhsPlELKl..sspILFVNHHEGMlCIK+plpIps.....pspIssLLTPYEYHNppSllps.ssh....spl.E...p....D...cVpsLMSKLlQYYY+sahplFsThPVPKLIVSLTNLKNAMPVhpYpp..........p.hlssLPsGpSVsV.s.spIhhNsKMF+LWTLVRDs+LhT..............................................................................................................................................................................................	2	0	0	0
+3184	PF05094	LEF-9		Late expression factor 9 (LEF-9)	Moxon SJ	anon	Pfam-B_6326 (release 7.7)	Family	Late expression factor 9 (LEF-9) is one of the primary components of RNA polymerase produced by baculoviruses. LEF-9 is homologous to the largest beta-subunit of prokaryotic DNA-directed RNA polymerase [1].	19.50	19.50	22.60	22.50	17.20	15.60	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.64	0.70	-6.11	7	276	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	131	0	0	138	0	180.10	76	98.01	CHANGED	hlpFhsKsPocF-LLhDPscl.ssshFhshccF+hFLKslIsDLK+..KhNaFNSLl-QLIsVYp-ss.t+NEHTchLuRIlhATslVVT-LPSNVFLKKLKhNKFTDsIsYLILPNFILWDHNFllFLNKsFNSKH-suLVDISGslQKIKLTHGVIKDQlQsKNGYAGQaLYSTFLNTASFYANVQChNGsNEIlPP+sSlpRYYGRDVsNlRAWTTRHPNISQLSTQlScVhts....-s.sDWNVKVGLGhFsGANpDCDGDKcVITaLPpPNSLIDLECLLYGDPRasFICFDKNRLuFVSQQIYYLaKNlc+lEpLhcohPllhsLWppa+...stpFupRLEhLLRDssLlhSSNsSaLLappLsplIcsEEMVCuDcElhsLsGpFsslIcSGAKGStsLlcSTcpY+pTcssDlDTVupRAlTuLNSaIoSHNRVKlsGGDIYHNTsVLQNlYLKsshICYKsDshsluslCsLPSEFLFPEHLLDhF	....................................................................................................................................................................................................QaLYSTFLNTASFYANVQCLNGsNEIlPP+uSl+RYYGR.DVs...N..VRAWTTRHPNISQLSTQlScV+ps.......-s..TDWNVKVGLGhFsGANT.......................................................................................................................................................................................................................................................................	1	0	0	0
+3185	PF05150	Legionella_OMP		Legionella pneumophila major outer membrane protein precursor	Moxon SJ	anon	Pfam-B_6492 (release 7.7)	Family	This family consists of major outer membrane protein precursors from Legionella pneumophila.	20.90	20.90	21.20	22.60	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.87	0.70	-5.30	2	182	2012-10-03 17:14:37	2003-04-07 12:59:11	7	2	18	0	16	92	0	199.50	58	94.10	CHANGED	MhsLKKTssAVhALGSSAlFAGTMGPVCTPGNVTVPCERTAWDIGITALYLQPhYDADWGYNGFTpVGGWRpWHDVDhEWDWGFKLEGSYHFNTGNDINVNWYHhDssoDHWA.hsphHsYs.pWDAVNAELGQFVDFSANKKMRFHGGVQYAhIcsDVNRahNsFhhssFNSKFNGFGPRTGLDMNYVFGNGFGlYAKuAsAILVGTScFhDs...hsF.hGSKNAIVPElEhKLGADYTYAMAQGDlTLDVGYMWFNYFNAhHNTush.....suhETDFuASGPYIGLKYVGNV	..................................................................................................................................................YHa...D...sD.....o....D........+W.....s..........s...hu..............s.........h.............H...........s...........Y..s....N....+WDAVNAELG.QFVDFSANKKMRFHGGVQYARIEA..D......V.....N.....RY.........F.........N...N.....F......A....F.N.....G....F......N..S.....KFNGFGPRTGLDMNYVF.GN...GFGVYAKGA...AAILVGTSD.....F...Y.........D..G......................I........s......F......I......sGS..K..N....A..IVPELEAKLGADYTYA.M......A.QG.DL.T..LDVGYMWFNY...FNAM...H....N.T...uVh..........................................................................................................	2	10	10	15
+3186	PF03020	LEM		LEM domain	Bateman A	anon	[1]	Domain	The LEM domain is 50 residues long and is composed of two parallel alpha helices.  This domain is found in inner nuclear membrane proteins. It is called the LEM domain after LAP2 Swiss:Q62733, Emerin Swiss:P50402 and Man1.	20.50	20.50	20.50	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-7.94	0.72	-4.51	8	494	2012-10-03 03:04:30	2003-04-07 12:59:11	10	23	94	5	269	440	0	41.30	39	7.99	CHANGED	sDlspLSDsELpspLppYGlssGPIluoTR+LYEKKLhKLccp	...................ppLosp-LpppLhch.Gls.s.GPIs..soTRplYEKKL.h..ch................	0	66	87	174
+3187	PF04011	LemA		LemA family	Bateman A	anon	COG1704	Family	The members of this family are related to the LemA protein Swiss:P71452 [1]. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular [1]. The exact molecular  function of this protein is uncertain.	21.00	21.00	21.00	22.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.03	0.71	-5.18	10	2668	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	2218	1	681	1981	523	183.70	35	94.86	CHANGED	hhsslhlhllllllslhsssuYNsllst-cslcsAWSplpsphQRRsDLIPNLVETVKGYAuaE+cTLccVsEARA+ss........thpcspshp+hppApsELouuLuRLlllsEsYPsLKANpsFhpLpspLcGTENRIAluRpcYNcuVpcYNspl+pFPollsA+haG..F+stshFpss..EutpssPKVcF	...........................................................................hh....lllh.l..l.l.l.l..l.s.h..h.s..h....s.s.Y..NsL...lp...hcppscpuWup.....l-sQh.pRRsDLlP..NL........Vp..TVKGYAp.......a..E.p....p.....sL.p..p.....VscA..Rspss...................................s..s...p..s...hpp..ht....p....A..p.s.p.L.....osu......L...u..p..L.h....slsE....s.YP.-.LKAsps..FhpLQ...ppLp.sTEN+IuhuRphYNssVppYNspl.c.p..FP.s.s.l.l.A.t.h.hu.......a.p.t.t.s.hapss....tt.t...p.p..s.PpVpF.............................................	0	226	462	587
+3188	PF02998	Lentiviral_Tat		Lentiviral Tat protein	Bateman A	anon	Pfam-B_1519 (release 6.4)	Family	This family contains retroviral transactivating (Tat) proteins [1,2], from a variety of Lentiviruses.	19.80	19.80	19.90	21.70	18.20	19.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.07	0.72	-4.16	7	50	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	15	0	0	41	0	58.70	81	96.23	CHANGED	.EEhPpRR.stscEhs.h..a.cEh-sWpasS.RVPGEhLQRWLAMLpsuR.R++VlREMQKWMW+aPKAPVIRsCGCRLCNPGWGo	.....Ep.s.t..ht..th..h..h.c-h-sWphhS.RsstphLQhWLAMLp.tp.RtpVhpEhQhhhWh..tA.lhRsCGCRLCNPGWGT.	1	0	0	0
+3189	PF02024	Leptin		Leptin	Bateman A	anon	PSI-blast P41159	Domain	\N	25.00	25.00	25.40	25.00	24.90	23.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.02	0.71	-4.53	7	218	2012-10-02 01:28:15	2003-04-07 12:59:11	10	1	124	1	24	189	0	120.30	70	91.48	CHANGED	VPIpKVQDDTKTLIKTIVTRINDISHTQSVSSKQRVTGLDFIPGLHPlLSLSKMDQTLAlYQQILTSLPSRNVlQISNDLENLRDLLHLLAhSKSCsLPpspGLEohESLGGVLEASLYSTEVVALSRLQGSLQDMLpQLDLSPGC	...................................lpsDoKsLlK....TIlsRIsDIS+hQSVSSKQRVTG...LD.F...IP...GL...H...PlLSLSKMDQTLAlYQQILTSLPS.RNVlQISNDLENLRDLLHLLAsSKSCsLPpsp..uLc..oL-SLssVLE...ASLYSTE.VVALSRLQuuLQ-hL.pLDhuPtC....	0	1	3	6
+3190	PF03588	Leu_Phe_trans		Leucyl/phenylalanyl-tRNA protein transferase	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.40	22.40	23.00	22.60	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.97	0.71	-5.13	9	2004	2012-10-02 22:59:21	2003-04-07 12:59:11	9	3	1956	17	506	1355	651	170.90	46	73.57	CHANGED	ssspLltAYppGlFPhhpp..spslhWasP-sRullhs-.plHls+slp+sl+pshapVphstsFtsVI-uCAsst...tpsTWIspthpcsYhpLHphG..aAHSlEsWpscc.....LVGGlYGlulGplFaGESMFSptssASKlAhlpLschLcstuatLlDsQh.spHLcphGApclsR	..........................................s.stRLLtAYppGIFPWass........spP..ll...WWS.....P-.....PRuVL.....h..Pc.....ph...H.lS....+Sh++....h....h....+........p.........s..............a....clolspsFspVIcu.CAss....+..................p.........puTWIscplhcA..YpcL....HchG............aAHSlElW..p.s....s..c.......................LVGGlYGVul..G..p...lFhGESMFS....c...t....p....s...A...SK..sALhh.Ls.p.c.htpp..G...h..pLIDCQ.h.h.s.sHL....tS.LGAp-IsR.....................	0	155	324	426
+3191	PF01819	Levi_coat		Levivirus coat protein	Bateman A	anon	PSI-BLAST 2ms2	Domain	The Levivirus coat protein forms the bacteriophage coat that encapsidates the viral RNA.  180 copies of this protein form the virion shell. The MS2 bacteriophage coat protein controls two distinct processes: sequence-specific RNA encapsidation and repression of replicase translation-by binding to an RNA stem-loop structure of 19 nucleotides containing the initiation codon of the replicase gene. The binding of a coat protein dimer to this hairpin shuts off synthesis of the viral replicase, switching the viral replication cycle to virion assembly rather than continued replication [2].	19.40	19.40	21.40	21.00	19.20	15.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.25	0.71	-4.56	5	151	2009-09-11 00:12:26	2003-04-07 12:59:11	12	1	26	164	0	161	0	102.30	51	72.02	CHANGED	ApLpslVLsspGuTGNsTlsls...VNssNGVAEllpusuVPutEpRVTlSVRQoSssR+KYslKlcVPslsoQTVNGlssPuVsRpuYssV-LoastaSTscER.slIsppLAALLKDshlIcusIssNsGa	..uphpphsLst.GtsGp.Tls.....ss.sNGVuth.ps.ss.u.th+VThShttsutpp+paplplcl.pssspTssGsp.PssshpuYhsh-LTIPIaATssDs.tLIsKuhtGLLKDGsPIsusIusNSGh...	0	0	0	0
+3192	PF01726	LexA_DNA_bind		LexA DNA binding domain	Bashton M, Bateman A	anon	Pfam-B_1975 (release 4.1)	Domain	This is the DNA binding domain of the LexA SOS regulon  repressor which prevents expression of DNA repair proteins. The aligned region contains a variant form of the helix-turn-helix DNA  binding motif [1]. This domain is found associated with Pfam:PF00717 the auto-proteolytic  domain of LexA EC:3.4.21.88.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.96	0.72	-4.41	9	3433	2012-10-04 14:01:12	2003-04-07 12:59:11	11	9	3000	10	740	2157	1670	64.30	40	31.34	CHANGED	MpsLTtRQp-lLchI+splpppGaPPohtEIuptlGhpSssuspcHLcALp+KGhI-hsPGpsRu	.............................tLTt.RQpcll-hI+ppl.p.ppGhP..P.ohpEIuptlGh.....p.SssusccHLpsLp.+K...GhIchssspsRu............	0	239	478	621
+3193	PF01790	LGT		Prolipoprotein diacylglyceryl transferase	Bateman A	anon	Prosite	Family	\N	24.90	24.90	24.90	24.90	24.70	24.80	hmmbuild  -o /dev/null --hand HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.67	0.70	-5.44	67	5002	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	4357	0	1133	3460	3019	251.80	31	88.04	CHANGED	hsPlhhplG.P..l.......sl+W.....YGlhhhhGhllAhhl.ut+psppt...........shst-pltDhlhauhhusllGuRlhYV......l...aph......shY.....hpp.........P.hplh...plWcG........GhuhHGGllGshluhhla............................s+ppp..ls.....hhphsDhlAPslslG.uhGRlGNFhN.tElaG+.....s....ss........athl.P............................................t....................th.......................h.hh.hHP.......o.LYEuhhp.lllFllLhhhh....++..hthh.GtlhuhallhYulhR.hhlEhhRp..sshh............hhhh...............lphuQlLSl.hllhGlhhhlhtp	................................................................................................sPlhhpl.G..P....l..........sl+W.....YGlhhlsG.hlh.Ahhl...up..+..c..hp+t..................................sh.s..p...-...p.l..-...ll.h...h...u.h.lu.s...ll.GuRlhYV......l......aph............................shY...............hps..................P....hp.lh..........p.lW.pG............................Gh.....uh.H.GGll.G...shls..hhl.a............................................................s.+..+.p.p.....hs.......hh.p.hhDhl.APslslu.uhGRh.GNF...hN...tE.haGc............ss......shs...................huhlhs.........................................................................................................thshh..hHP....o..LYEuhhp.llhFll..L.h...h.ht....................++.................h............t......G....tlhu....lalhhYuhh...R.hhl.E.hh.Rp.ss.h..........hhhh.............................lphuQl..LS.ls..h..l.lh.Glhhhlh..t......................................................	0	398	772	979
+3194	PF00556	LHC		Antenna complex alpha/beta subunit	Bateman A	anon	SCOP	Domain	\N	20.50	20.50	20.80	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.65	0.72	-4.11	28	509	2009-09-11 14:13:18	2003-04-07 12:59:11	15	1	110	48	157	438	71	38.60	27	65.17	CHANGED	ptchhclac.hhsh...hhhhsllAllsHhllhs...tpsWls	.................chhplas.hhsh...hshhhslAllsHhllhs.....hpsWl.........	1	40	76	92
+3195	PF04991	LicD		LicD family	Moxon SJ, Bateman A	anon	Pfam-B_5278 (release 7.6)	Domain	The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [1]. These proteins are part of the nucleotidyltransferase superfamily [2].	22.60	22.60	22.90	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.53	0.71	-4.22	142	2479	2012-10-02 22:47:23	2003-04-07 12:59:11	8	25	1053	0	634	1816	209	187.40	23	55.89	CHANGED	sccpslphalstGoLLGhh+csshlPWDsDlDl.tMshc-hp+.Ltp.hhsp.......h.............................................phlh-ssohhhpptptstp.............csGla.IDIhsl....s.hs................................................................................................ht.ttpphht...................ppc.hhshspl.Plpps.FEGh..hhlPsshcphLpptYG	..........................................sccpslp.aalstGTLLGAlR.c.p.G...h.IPWDDDlDl..sh.R.c.D..Y...p....+...hhp..hhpp.....h.t.................................h.h.t.............h.................................tplhc.t.ss.hhhpp..t..ht.h........................................pulh..lDlhsh........Dhhsp........................h....................................................................................................................................................h..................h.....p.th.p..tp..............................hshtp.s.phhs.h......................pp..hh.sh.p...ht......hh...h.FEsh....h.hPtpacphLpphYG....................................................................................................................................................................................................	0	221	392	560
+3196	PF01291	LIF_OSM		LIF / OSM family	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.50	20.60	20.30	20.30	hmmbuild  --amino -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.17	0.71	-4.31	5	88	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	43	8	39	131	0	150.60	44	76.61	CHANGED	sLLsQLQNQssLhssou.oLL-PYI+lQGLssP.sLcctCsp+ssDFP.SE-sLpcLoRhsFLpTlsATLGslLppLocLQQcLscsAch...........KLssAccNlRGLtNNVaCMApLLp+Su...hsEPTpss.G...PsPsTossDsFQRKltGCpFLtGYHRFMuoVGQVF	........................................................LhsQlppQhs.lp.sou.sLh..Yhpu.QGpsh.......P.....s...L...c.....c...h.C.s...s...sss.FP.....c...s.s...hsphs+..h..st..Lh...p...l.hshLuss...L...sslTc....QchLssssh............LhpKLpsstsslRGLhsNlhC.hlsph.apsu....phsss..........sPsT.sspDsFQ+KhhGCplLtpY+phhuslupsF................	0	2	2	8
+3197	PF00549	Ligase_CoA	ligase-CoA; 	CoA-ligase	Bateman A	anon	SCOP	Domain	This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.80	0.71	-4.62	20	8836	2012-10-02 00:59:22	2003-04-07 12:59:11	14	29	3569	68	2607	5875	4883	125.00	32	32.56	CHANGED	lhsGGTLAhEshtllpts....................supstshlDlGsDsas.........ssphtctlphhssDs.cVpsILlslhlGhGss-t.AuullpAhccsp.......tplPlVuplsGTssD...t.h..pptphLpcuGltlhsusspAstsstsl	...........................hspuusLshpshc.lpth...............................G.hs....ushl..slGGssh....................spphh-slchhhs..Ds...ps..c.....uIlh.h.hG..............sps-t..As.u.h.l.p....A.hppht..........................thPlVshl..t...G..ssAs..............tttt..hl.h....s...u...G.h....s.hsssc.hs.tstt..h..................................	0	824	1565	2169
+3198	PF00412	LIM		LIM domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family represents two copies of the LIM structural domain.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.69	0.72	-3.90	38	16362	2009-01-15 18:05:59	2003-04-07 12:59:11	17	199	437	88	8615	14824	48	57.20	26	24.59	CHANGED	CuuCsctIh....sp.hs..uhscsaH.pCFpCspCpp.Lssss....ha.p-u..c....lYC+p.cahcth	................................CstCsp.Ih...................stt.h.....h.................u..........h.......s..........p.....t...a..H.....p..CF......p..............C.........s......p...C.........p..p..t....L....s..sts..........ah....p.....cs....p...................haCpp..sa.t..h....................................	0	2081	3129	5636
+3199	PF01803	LIM_bind		LIM-domain binding protein	Bashton M, Bateman A	anon	Pfam-B_1352 (release 4.2)	Family	The LIM-domain binding protein, binds to the LIM domain Pfam:PF00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) Swiss:P70662 is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons [4]. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development [2]. The Drosophila protein Chip Swiss:O18353 is required for segmentation and activity of a remote wing margin enhancer [1]. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development [1]. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions [1].	19.80	19.80	19.80	20.60	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.25	0.70	-5.26	42	464	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	238	0	283	431	0	206.00	32	39.09	CHANGED	hhRLhpasccL.....ssh.......................sppssltaWppFVpcFFs.........ssushRhslpttss.............................................K.pFElshshlPRaa.pohFsoGlpchphhl.ptsp-pshssushhl-ss+sshhhhatsss..........................plsscGpL+shF.................s.phKIchh-hsspsHpEhl.sRshlt.hht...................t.....t.chspspphp...tt............l.......pslsp.hGlspsshphLclu-llspMpsLhsapppps.luPh-uL+p	...................................................t.hRlhph.c+l.....pph........................sppss..aWctFss-FFp.........ssAhhphshshtsss..............................................K.pa...pIstsllPRaF.pohF...........cuGlp-hhhhl....thp.c..p.s....hts.......s.....tlhl-sspsshlo.ascsh..........................pVs..s-GpLhlpF.........................cs.h+IcsWcFs.............h+pa...cEhl.PRshlt.tsp..................................-.phhsp.ht............................................................................pslsc.hGloptslp.hL.............cls.llpsMp-Lhshp+phs...luPh-sL+....................................	0	75	140	221
+3200	PF00538	Linker_histone	linker_histone; 	linker histone H1 and H5 family	Bateman A	anon	Arne Eloffson	Domain	Linker histone H1 is an essential component of chromatin structure. H1  links nucleosomes into higher order structures Histone H1 is replaced  by histone H5 in some cell types.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.35	0.72	-3.88	20	1947	2009-01-15 18:05:59	2003-04-07 12:59:11	14	46	377	9	991	1945	10	71.20	32	23.85	CHANGED	uHPsht-MIssAIpuLKERpGSSh.AIpKYIps.sY.chslss..hshhl+puLK+sVpsGpLhpsK......GusGSF+Luc	.......................Pshtphlh....pAI.p...s.....L..c..E...+...s.G..o...ShtAIpKalps..pa...p....p..h...s.s.............h.t...ph.l+tsLKph.VspGpLhpsK..........G...sGoa+Ls..........................	0	258	429	691
+3201	PF04454	Linocin_M18		Encapsulating protein for peroxidase	Waterfield DI, Finn RD	anon	COG1659	Family	The Linocin_M18 is found in eubacteria and archaea [1,2]. These proteins, referred to as encapsulins, form nanocompartments within the bacterium which contain ferritin-like proteins or peroxidases, enzymes involved in oxidative-stress response. These enzymes are targeted to the interior of encapsulins via unique C-terminal extensions [3].	24.30	24.30	24.30	24.40	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.20	0.70	-5.48	59	323	2012-10-03 06:22:39	2003-04-07 12:59:11	7	3	313	13	123	298	12	246.00	34	89.18	CHANGED	Ms..LtRc.APlostsWppI..-cpstpsh+ppLsuRRhl-ltGPhGhshsulshsclpthps.ttt............lpsthRpshPlsplphsFpLstp-l-sscRsutshDhssltcAAcplAhtEDchIFpGhstsultGlhsssupttlpls..ssstshhpslscAlspLpps.....GhsG.PYsLlluschYstLtchtsp.G.hs.hc+lccll.susllhuPslcs..ullloscsush-LtlGpDlulGYhupsspshphhlhEohs	.............................................................................Ms.LhR-LAPlopsuWtpI..-pcsscoh++plu......GRRlVDVssPh..G.shuuVssG+ltplpsssps............Vtsp.hRpstPLlcL+VsFsLsRp-lDsl-RGupD.sDhpslc-AAcclAh.s.EDcsIF.........cGa....s.........sAu.....I....p.....Glpsu....su.s.st....l........s......L........s............pc..s..pshscslupAlspL+..h..u........GlsG...PYullLus-s..Ysplsc.s...s...-p....G.YPlhc+lp+ll.s.....GcIlhuPulcG..AhllosRGGDa-LplGpDluIGYhuHcsp.sVpLalpEohT..............................	0	44	82	104
+3202	PF03583	LIP		Secretory lipase 	Finn RD	anon	Pfam-B_3085 (release 7.0)	Family	These lipases are expressed and secreted during the infection cycle of these pathogens.  In particular, C. albicans has  a large number of different lipases, possibly reflecting broad  lipolytic activity, which may contribute to the persistence and  virulence of C. albicans in human tissue [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.75	0.70	-5.21	12	1102	2012-10-03 11:45:05	2003-04-07 12:59:11	9	8	480	0	414	1391	144	260.10	24	62.70	CHANGED	hQhuusho..Tl.TQh-hhhlsshLppGaaVVlPDYEGPKo.....TFsVGRQSG.pAsLDSIRAsL+otphoGlssDu+VulWGYSGGulAouWAAtLQPpYAPELpps.LlGAAlGuhssNlTuhscusDGolFuGlls.uLsGlANEYP-h+phlhpclsctup.shcphsptClusulhcashpphhTG.p+sFppGhslLcs..sls+hlp-NtL.hhspphlPplPlhlYHGshDpIlPItsscthhpsWCshGhsslEFuEDhhsG.......HhsEshsGAPAAloWlpsRFsGcsslpG	.........................................................................................................................h...................p..h..l...sth.L..s.pGasVs.ssD.....Y....p...G......ss..............sah.s.....s.....p.....t...t.u..tu.....l..LDu.lR.A....uhp...h...t..t............s.l......s........s........s......l...slh..GaStG.G...h.A.u....h....h.A...A....p....h.t.....s.....s.......Y...........A....P....ELs........lh...G.s...s.h...Gu.s..s.........s....s.....l.....t..........t.....h.......h........p..........t..........h........s.........s..........s............h..............h..........s......G.......h..............h..............s..........h.......s.....l...h........G.l........t....p..t...a...P.....p...l...p..........l...p...p.hl.ss.p..u....p...t..h...h....p...p....h.p...p....t..C...h...s..t...h...h..h.t...h..........s.................h...t...p...h.......................................h.........t..s........p.h..h...t....p..............htph.h...p.p..p.....th........................p....h...hP.....s......h....Plhl....hp................u................h.t................D....t....l.....l.s....h.t.s.s.pt.h.h.p...p.ass.......t.........G...............ss.l.p........a..t..t.............h..s..t..........Hh....h........s....h...s..........s...h...t.altthhtt..................................................................................................................................................................................	1	83	269	368
+3203	PF03279	Lip_A_acyltrans		Bacterial lipid A biosynthesis acyltransferase	Mifsud W	anon	Pfam-B_1803 (release 6.5)	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.61	0.70	-5.54	13	5234	2012-10-02 00:16:30	2003-04-07 12:59:11	8	10	2565	0	1047	3702	3078	280.50	24	90.64	CHANGED	phpFphphhhPpYahs.WlGluhlhllshhPhshhctlsstlGthht..hhhpctpcpA+pNLshsFP.-ho-sE+-pIlcpshpohuhslhEhuplshhs...ccclpcphc..............htGLEplcphhppscullLhssHthsh-luuhhlsppts..shushtppptN.hlsalhsphRpphstclls+pss........lcshlcuL+pGc.slhhlsDpDhssc.ulhVsFFus.sssssssuhLuh+os..AsllPlhshhpscs...ttashplpPshchp.pt....DspplspthNchlEphItspPEQYhWlp+paKo	...............................................................................................................h...................h.h.h....s.h..h.h....h...l.s.hl.Ph..hh..hh.l.u...t.tl.Gthsh......hh..h..p..p..pt...c.h.s..p..t...N.L.p.h.s...F......P......p.......h.o..p........t........-........+......ctll.t.c....a.psh.u.h.s.h.h....Eh.s.h.h.h.h.hs........s.p.c.l.p.p...h...h.c...................hp.G..h..-...t...l....c..p..h....t..t..p..s..c..u..ll.l.l.s.sHhhs..hE....l....s....u...h...h....h....u....t.....p....t........th...u...s...h...h...............p......p........N...shh..-....h..l.h.....p......p....s..R..t....+......h.....s....t.....p....h.....l..s...+......p..s.....................l+...s.hl.....p...s....L.....+.....p....G....p...hlh.h..h..s.D........p...........D...h.....u..........c.......t....u...l.a....l...s...FF..u....h.......s...s...s...s.s.s...s.s...h.l.h.p...ths....As.l.l.s.h.h.......s.....h.....+..p..scs....................ta...p......l......h....l.....t.....P...s.....h....c....s......s..t.t...........Dt..p....p....s....s...t...h....h...N....c...hl...Ep...h.ltttP-QY.h.Wha+RaKp.................................................................................	1	274	606	844
+3204	PF00151	Lipase	lipase; 	Lipase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.18	0.70	-5.22	16	1975	2012-10-03 11:45:05	2003-04-07 12:59:11	14	31	255	16	1058	2017	14	262.60	27	71.62	CHANGED	ppVshtplss.upp.shss.shpcsh+.h..psPpphc..s+FLLapscs....shQhh..ucssTlcsspFsss+hTphIIHGasscG......................pEsWlschscshhph..cssNsIsVDWtsuupshYs.AstNl+lVGtElAthlshLpsphsas.psVHlIGaSLGAHVAGtAG+phsG....plGRITGLDPAcPhFpsssp.sRLsPuDApFVDsIHTsst.....LGhGhoQpVGHlDFFPNGGpp.hPGCppsl...........th...hhtCsHhRSh+Yas-Slh..Nsc.sFsuasCuShppFppscCasC.tt...pCspMGah.hscashppttlptcaaLpTsspSsF	.....................................................................................................................................................................................................phhlh...t....tt........t......................h......................p.....s...h..t..t..s..t...a.....s.p.p.shhllHGatsss.................................pp.hh..p.h.h.p...s.hhp...t.......t.s..h.N.lls..lDW......t.....t......h.u.........p........t.........h.........Y..................u..s.t.s..s.p..h..l.Gt..pluph..lphL......t......p..h...s........h.s...h.....p..p.......lHlIG.aSL.GAHl.uG..huGph.hpt..........pl..s..R...IT..............G..L.....D...PAt........P.h....F.p..........t......s........s.........t..............+.....Ls...s.D.A.pFVD....lIHTss...............h.....sh...G.h....pshG+hDF.YP.N....G....G.p...QP.GC...t.........................................................h...CsH.Ruhphah-Sl........p.p..sh..hu..h...C..s..s.h.p.t.......h....t..s....C..hs......................tps...hG......h.....t......t..............................................hhh.stt..sa..................................................................................	1	307	390	782
+3205	PF01674	Lipase_2		Lipase (class 2)	Bashton M, Bateman A	anon	Pfam-B_968 (release 4.1)	Family	This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyse ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol  and free fatty acids [1]. Swiss:P37957 is a extracellular lipase from B. subtilis 168 [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.38	0.70	-5.03	15	461	2012-10-03 11:45:05	2003-04-07 12:59:11	13	7	242	42	222	809	70	188.40	27	62.77	CHANGED	psPllhlHGsu........s.tussapphhphFhccG.YssuplYATTaGcssp.sshppsp....pCpal.pplRchl.AVttYTGs.+VDIlAaShGsPIARKAIlGG..pCs.DssssLGssLsppVcTFlulu..............GsNtGhssC.u............hh..hC.NhpsGLh....C....................tScFLpDINsps+h-.uptlaoIaSpsD-llt....tphsCG+pouhIPsucshp.YcthsHppshppTsthQhp	...............................................................pPV.VhlHGsu...................s.sh.hs.a.st.h.tsh...Lts.....p.G...ast..........l..auh.s..a...s..st..st...........s.....hpsst.................h.....s....t...............p........l.s.pF...l-....p.V...L...t..t...TG....A.pKVD...lluHS.G.u.s.l.sRhY..l..c...hh.......sus...c....p....h.t....tl.s..s.......h.s.p.h.t.s.......h.l.u.l.t.........................................u...s...s.h.sh..s.h..................h..hs..s....th....................................................................................Stal.......ppl..N....s....s...s.....h.....u..thhslh.ophDphlh.....................................................................................................................................................................................................................................	0	88	142	214
+3206	PF03280	Lipase_chap		Proteobacterial lipase chaperone protein	Mifsud W	anon	Pfam-B_4313 (release 6.5)	Family	\N	21.10	21.10	21.30	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.31	0.71	-4.78	34	328	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	282	2	63	274	15	184.30	29	59.61	CHANGED	sLhppYlsY+pALssLp..............tshtsphsl.sslpphhpphtsLpppaFuts.tpuhFGsEpphpphslc+lpItpsssLospp+tptlttLpspLPsslppu.ppptpt.pcltpttpth.tpG.ssspplhtht.tphlGs-uApRLtplcppctsWcp+hssYhppRspI...ssslspsp+pttlspLRpptF.sssEth	..........................sLappYltY+psLupLp...................sttssthsh.sthpphhpphtsLpt+hFu.sttpshFupEpthpphsLc+h.....c.Ihpst.sLsst.p+tptlp.t.Lh.....tp..h.Ppthppu.....p.........tp.sph.tpLpp....tttt......h..ttt........uss..pphhttR...sthl.G...s-.uApRLtpL-ppcssapp+hssYhtp...RspI.......ps..tLS....sp....-+ptpIpp.LRpppF.sspph....................................................	0	9	23	45
+3207	PF00657	Lipase_GDSL		GDSL-like Lipase/Acylhydrolase	Bateman A, Mistry J, Molgaard A	anon	Prosite & Pfam-B_543 (Release 7.5)	Family	\N	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.79	0.70	-4.54	65	4517	2012-10-02 11:02:24	2003-04-07 12:59:11	17	78	1181	20	2407	11569	2075	269.30	15	70.51	CHANGED	lhshGDSloss........................stsh.tshtshl.t........................shshshhstuhuGps...........................................................................................t.hht.h.ttsthsssllhlhlGsNDh..........................................tts.ptshsphhsplpphlptlp..ptssp.....shhhhsts....................................h.t.tthpphsttasphlpcls.......................tthphshhDhaphh.ph.............................................................................hhhDsh........Hsospupphhuctl	............................................................................................................................................................................................................................................................................................hhsFGDSlsDs...............................................................................................s......t..p.....h...............................................................s......h.s...h...s...h.......s...h....s.........s..G.th..s.ssthh...........................................................................................................................................................................................................hht.....h...h...t......t........t....s...t...t........h....h.......s.....p....s..l........h.....h..l......h.G.s.N..Dhh..................................................................................................t.....p...t....h..h.....s...t....h....h....s....p....h....p........p....h.......l....p....p............L....h.....ph.....G..u+..........................p..h......h.l.h.shs...shs...........................................................................h......................................t.....t...t.......t....s.....h.p....t....h...s....p......h....s.......t...h..a.....N..p...t...l...p.phl...tt........................................ht.t..h..............sh.p.h...h..h....h.....D...h..a....s...h.h......p.h.......h.tp.stthsh......sh...............................................................................................................................h.s.ppah...h.h.....D.s.h.................H.opt.spphlup..h...............................................................................................................................................................................................................................................	0	460	1376	1961
+3208	PF00061	Lipocalin	lipocalin; 	Lipocalin / cytosolic fatty-acid binding protein family	Eddy SR	anon	Prosite and HMM_iterative_training	Domain	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.71	0.71	-4.21	156	2221	2012-10-03 08:47:39	2003-04-07 12:59:11	18	19	289	489	974	3261	80	128.60	17	76.93	CHANGED	sG.pWhhhuhts.....hcphhpthssshtphp...sssshthpthp...h........pss.p..sppts.shcps..ppshphshp.......tssp...phpsl.ph-hpshhlhhtptp....tt.pshhtplhscs.clstph....h.th......shspss.hhph.pps	.................................................................................................G.pWh.hhs...ts......hpchh.p.t.h...s....l.s.h.t.thp.....h...sssshss.hhht.......h......................................pss.p........hpph...s......s.h..c..ss......ph..s..h...c..hshph.t.........hsssp.........chp...sl...sh.-h.t...s..hhl.h.hpptp......u..p..p..sh..htpl................s....cs...p.h....ph..................shtt..hh.....................................................................	0	111	187	385
+3209	PF00820	Lipoprotein_1		Borrelia lipoprotein	Bateman A	anon	Pfam-B_1321 (release 2.1)	Family	This family of lipoproteins is found in Borrelia spirochetes.  The function of these proteins is uncertain.	25.00	25.00	40.00	25.00	18.30	20.40	hmmbuild  --amino -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.71	0.70	-5.30	7	599	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	62	32	2	611	0	175.20	69	94.88	CHANGED	sSShDEKsusphDLPuthc..V........hVSKEKsKDGKYsLcAhVDplELKGTSDKNNGSG.sLEG.KsDKSKsKLoIu-DLsphThEhacpss.ThVS+KVspKDtS.TEEp..h.cpGcLSpKplTRsNGTpLEYo-Mps-.susKAhEsLKN.lphEGsLsus.KTTLplpEGTVTLo+EIsKsGclplhLsDo.ootuoKKTusWsspTsTLTISsNSKKTKpLVFpp-sTITVQpYDSAG.TsLEGoAsEIKsL-cLKsALK	........................................tsp.DLPGtMc..V........LVSKEKsKDGKYsLhATVDKlELKGTSDKNNGSG.sLEGsKsDKSKVKLTIoDDLupTThElFKEDGpTLVS+KVs.KDKSS...TEEp..FNcKGc.lSEKhlsRuNGT+LEYTphpss.ssuK.ApEsLKs.hhL..EGsl.sst.csp.l..l.p.puTVsh........................................................................................................	0	2	2	2
+3210	PF03202	Lipoprotein_10		Putative mycoplasma lipoprotein, C-terminal region	Mifsud W	anon	Pfam-B_2205 (release 6.5)	Family	\N	22.40	22.40	22.40	22.70	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.96	0.71	-4.14	12	80	2009-09-11 23:29:08	2003-04-07 12:59:11	8	3	32	0	36	80	0	128.20	30	19.30	CHANGED	sITQGPNlIGIHANEKENtETpKFVNWFLNsp.oWcspp.sptpppppp....pTsApaFAESASYILPLKEhFcps.....ptctspsp...........................t...NoascKAL-lFpplucsplluYSDPSDFRSGKFRDuIGusFN.AsVsSKs	.........................sQGPsLIGIHu.N-KE.-ptTpcFVpWh.........l.sp...ppsapt.p..t.......p.....p.pp.............tTsupahscsuSYlhPhKphhsps.....p....ttp.............................tpNhhhcps.h.chhp.p.h..p..p..s..p..hs.a.p.-P.ushpSupFRcslsosassh.s........................................................................	0	23	34	34
+3211	PF03260	Lipoprotein_11		Lepidopteran low molecular weight (30 kD) lipoprotein	Mifsud W	anon	Pfam-B_4108 (release 6.5)	Family	\N	25.00	25.00	28.90	45.30	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.77	0.70	-5.38	6	84	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	4	2	52	54	0	234.40	40	85.01	CHANGED	VhusCVlAuSAuls-hsss.....sc.LE-cLYNSllsGDYDoAVpKShEhpcQuKGsIIpssVNpLIcDupRNTMEYAYpLWltsG+-IVKcYFPlpFRlIhuEssVKLI.KRDNLALKLGsssssss-RIAYGDucDKoS-pVSWKFIsLWENNRVYFKIhNTccsQYLKLu..sssssssD+hlYGssoADTaRcQWYLQPAKY-NDVLFFIYNREYNcALcLuRsV-usGDRpAaGHsGcVtG.P-lFuWhIssF	.........................................p........sp.lp-pLYNsllsuDYDpAVppohpl.ppspup.lIpplVscLIcstcpNsh-aAYKLW..h.ssup-IV+chFPhpFRLIhspp.hlKlI.+p.shALcLussss.ts-RhAaGDupDK..TS.cVSWKhlslW.ENN+VYFKIhNschspYLKLu..ssssssGD+hsaGussu-opRcpWaLpPsc..a-sclLFaIhNREYsp.uLKLupsV-ssGDRhsaGpsGpVsGpP-hauWhIps......	0	52	52	52
+3212	PF03330	DPBB_1	Lipoprotein_13;	Rare lipoprotein A (RlpA)-like double-psi beta-barrel	Mifsud W, Studholme DJ	anon	Pfam-B_3255 (release 6.5)	Domain	Rare lipoprotein A (RlpA) contains a conserved region that has the  double-psi beta-barrel (DPBB) fold [3,4]. The function of RlpA is not well understood, but it has been shown to act as a prc mutant suppressor in Escherichia coli [1]. The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions. Another example of this domain is found in the N terminus of pollen allergen.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.87	0.72	-3.98	127	5162	2012-10-01 21:39:58	2003-04-07 12:59:11	13	43	2566	5	1785	4300	468	87.00	26	33.33	CHANGED	ssssssuha......ssu.....susGpsaphps..sspts....................sps........pulsVplsDhsP................ssppthDLStsAatpluhh.........ps.Gl.ls.Vpa	.......................................................................su.uuhY.......sst............susGp..s..a.p..hp.s.hsuAcps..............................................hsp..s+s........s....t+ollV..plsD+sPh...........................ss.s.c.h.lDLSt.sAhp.p.l.uhh.........ps.Ghs..Vp.............................	1	492	1115	1484
+3214	PF03640	Lipoprotein_15		Secreted repeat of unknown function	Yeats C	anon	Yeats C	Repeat	This family occurs as tandem repeats in a set of lipoproteins. The alignment contains a Y-X4-D motif.	21.10	21.10	23.90	21.30	18.80	21.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.49	0.72	-4.52	22	995	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	347	0	428	953	61	45.30	32	56.64	CHANGED	hshlppcD...Gsh.hshcGhsLYpFs+Dpt.G..suss.hss...sWssht	.................htptc.....Gp.h.hs.hpGhsLYpFs+D.s.t.sGthpus...s.sss...sW.sh.....................	1	119	258	343
+3215	PF04791	LMBR1		LMBR1-like membrane protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_6189 (release 7.5)	Family	Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought [1]. Vertebrate members of this family may play a role in limb development [3]. A member of this family has been shown to be a lipocalin membrane receptor [2]	26.60	26.60	27.00	27.10	26.30	26.50	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.54	0.70	-5.91	9	832	2009-01-15 18:05:59	2003-04-07 12:59:11	11	11	260	0	554	801	5	364.40	17	72.65	CHANGED	lhhlLhhllalhshhlls+ap+hsct............................tplshhlsshsLuluhsulhLLPhslhu.............sphhh.hspsh...........htalssSlltuLWphlalhSsl.lallhPFshhFhESpsFssppKt..lpuplhEshshhhLhulllLsllhVhusl..........................h.................uhhshhphahshlhSssohhGllLLllhsshGlsch.sshhphhl+....................................spllpDspcph.p.shtpupls+clpp......t.....thtt...t...u.tt.hh..pt.hts.tph..t......................................................................................................................................................ssthphshshshshhsLLhhsshplLhVstshlplllshstlshhs.......ttsslthsohohhGhhGsslphllIhYLhhoohsGhaph.h....hphht.chccTshsphlhNsuhlLl.sSsLPlh.phlGlspaDhhssau...................slphlG.hhhlhlaplhFshloshsL	........................................................................................h.....hhhh.hh..hs....h....h..hlh.ha..tp...t.pt...................................hh.shhh.shhshhhshh.hlh.llPhslh........................................................................................................tt.......................................h.th....h..st.....t....h..h..h.......h.......W...........h.......h.......ahhs.hhhh.......hl..lPhh..ah...........-.......u.......ts.....s.s....t+...........lh...tt...l..h.t..s..h......hh......h..h..hh..h..h..l....hh..h.hh.h..hh.hh...............................................................................................................h...........h.t....h..h.sh..hh..u...h..h..shhGhhl.....hl....h.hhuhG.lst.l...Phshh..p..h..t.........................................................................................................................................p...........h..........................................t............h.............................................................................................................................................................................................................................................................................................................................................................................................h........h.h.h.hh......h...h....phhh..t.h...h..............................h...........................................h........h..h......h.h..h....h..ah........h.ssh.s.........h.t..h.....h..h...h.ttp.......hh.......h.p...sh...phh...th...................................................................................................................................................................................................................................................................................................................................................................	0	202	313	445
+3216	PF03923	Lipoprotein_16		Uncharacterized lipoprotein	Bateman A	anon	COG3056	Family	The function of this presumed lipoprotein is unknown. The family includes E. coli YajG Swiss:P36671.	20.90	20.90	21.10	22.90	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.58	0.71	-4.88	25	800	2012-10-01 20:48:06	2003-04-07 12:59:11	8	2	789	0	100	348	15	156.60	50	82.07	CHANGED	Pphs...ssp.ssspshslulsotDpRssphluplscssp.lphlssopslchhlppsLppphsupGapl..sssussplplplpchhssVpcushpachsoclplplhupsspG.chsKpYsussshpGs.hoAssscIcpslNplLspllscIhsDsELssalp	.....................Ppls.LPQQDPoLhGVTVSI.s.G.A.DQRsDQ..ALAKV..s.R..c..s..Q..l.Vs..LTASRDLRFLLQEVLEKQMTARGYMl......GsNGs...VsLQIlVspLYADVoQGslRY.N..IsT.KADIuIlATAtNG.sKh.oKNYRAoYsl..E..GA.FpASNcsIscAV.NoVLoDsIADMuQDTSlppFIK.................................	1	13	37	71
+3217	PF04200	Lipoprotein_17		Lipoprotein associated domain	Bateman A	anon	Pfam-B_3382 (release 7.3)	Domain	This presumed domain is about 100 amino acids in length. It is found in lipoprotein of unknown function and is greatly expanded in Mycoplasma pulmonis.  The domain is found in up to five copies in some proteins. This family also includes the Mycoplasma arthritidis MAA2 variable surface protein. MAA2 is implicated in in cytoadherence and virulence and has been shown to exhibit both size and phase variability [1].	22.40	10.00	22.60	10.10	22.10	9.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-10.47	0.72	-3.84	272	508	2009-01-15 18:05:59	2003-04-07 12:59:11	7	17	40	5	287	476	0	92.90	16	31.67	CHANGED	pls..pl....p..shphpssst...............tstlPS.plp.spsl.............................h.sshsapl..........phhp...........................ssDppGsL.plp..l.......ph.....phss.................pt...shp.lsGFps	.............................................................t.........t.php..tt...........pshhsS..pls..ppslp.....................................ts.sss.shpl................phhp.....................ssDppG.sL.plp.h..................pl...............phss..s..........................pph......php..lsGFp.........................................	0	162	287	287
+3218	PF00921	Lipoprotein_2		Borrelia lipoprotein	Bateman A	anon	Pfam-B_1509 (release 3.0)	Family	This family of lipoproteins is found in Borrelia spirochetes.  The function of these proteins is uncertain.	21.20	21.20	21.80	21.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.48	0.71	-4.24	16	1748	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	30	4	24	1776	0	138.10	61	67.07	CHANGED	lKpIV-sshKs..........tsss..sptsussspKssuKlhussusss..usus....susKAAAtluuVoGt-ILpuIspupct....tt.stsh-tsssssuhuhu.t....ptphstsuspKsAslAuGIALRuMAKsGKFAu.ts..ss..ssAVpuAuuoAVs...KlLusLphhIRKTVcusLcpl+EAlc	.................................IKEIVE.AAGGS...............EKL.Ks.......sA..A....u..t.G......E.s.NKsAG.KLF.G.K.A.G..A..u..A...p.G.DSEA................ASKAAGAVSAVSGEQI.....LSAIVpAAsA..........A........-Q-Gc.KP.t.-AKN.PIAAAIGct....-sGA..-...Fs....p....-..t..M...KK....D..D...QIAA.AIALRGMAKDGKFAVK..ss.....EK.....tt..........................................................s.............................	1	1	1	1
+3219	PF00938	Lipoprotein_3	Lipoprotein; 	Lipoprotein	Finn RD, Bateman A	anon	Pfam-B_1076 (release 3.0)	Family	This family of lipoproteins is Mycoplasma specific.	21.20	21.20	21.90	30.70	21.00	20.10	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.78	0.72	-4.21	16	55	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	4	0	21	46	0	81.00	39	33.93	CHANGED	sushpsllppsospchshu+shcLopsK+NLIssLKcuYEssPcpTsplLLsAWKhoL.-tcILpcphs.s.+F.psFGss.scpslpP	...ushcsllppooupchshu+shchspsKKNlIsuLKcSYEsNPccTsclLLsAWK.oh.-sclh.pphs....F.ps........................	1	19	19	19
+3220	PF01298	Lipoprotein_5		Transferrin binding protein-like solute binding protein	Finn RD, Bateman A	anon	Pfam-B_893 (release 3.0)	Family	This family of proteins are distantly related to other families of solute binding proteins.	29.40	29.40	29.90	29.60	28.90	28.90	hmmbuild  --amino -o /dev/null HMM SEED	570	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.99	0.70	-5.56	37	819	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	180	13	33	777	8	399.10	24	87.70	CHANGED	GGSFcl-s.....................stsssspptpP+Yp...Dssopp....pctphschppPuhGhuh+lhtpNhh..............tcc.s.lsppDh..h...................................tphptl.pthp...psspp............................................ps.p..t...ttps.pYVhSGhhYhtshs..p.tpp......hhtG..G..alaYpGppsuppLPs.....sspspYKGsWcahTs.sct...spc....ht.hst..tttssschuAhS.tp.........ctp.tsstpschuhsSEasV-FusKplsGpL..htNtphp.t.ptpstcppphYs...l-AcltGNRFpGpshs.spcsppp.....aPFso-...............spLcGGFaGPpuEELuu+FLssDpclhsVhuAKppsc......................ttpptthpshhDAhp.....................shsshsp+plss......FGcustLllsuh.IsLhs.............................................tssshtsppththtpcphpV.sCCsNLsYlKaGh...................................lppcsspt....................s........................................hFLpGpRTs.....pcplP..ppGs.scYpGoWhGal.ts....Tuaussuspppsts..tA-......FsVsFusKploGpLpspsspp..ssFsI.susIcu..NGFpGoAposc....shslDspsops.phh.h.supVsGGFYGPsAsELGGhFsassst...................................sts.supusVVFGAK+Q	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhst....................................................p.ttht.pp.hss........hs.phstLllsG..lsLhs...........................................................................t..p..ph.p.h..ss...psp.hpY..lpa.Gh......................................................hp.tstt..........................t..............................................................................ha..lpGp..s.............tptl.P......tup.shYp.Gp.hhthh..tt......................h....sst......tt....s...tAc.............VsFusKplsG.......p.l..ps...t.st.t............shph...pu.tIpu........NuF.pGshpsss.................................sspVpGtFYG......spupEluG.h..t.............................................t.tt.thhsV..FuuK+p....................................	0	10	15	29
+3221	PF01441	Lipoprotein_6		Lipoprotein	Bateman A	anon	Prodom_1149 (release 99.1)	Family	Members of this family are lipoproteins that are probably involved in evasion of the host immune system by pathogens.	24.60	24.60	31.60	31.50	24.30	24.10	hmmbuild  --amino -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.18	0.71	-4.45	42	763	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	58	21	5	741	0	168.60	61	91.18	CHANGED	-.tSspsAcpsups.sLscISKKIpDosAFshuVKEVETLlpSIDELA.KAIGKKIpsss...sLsss...usp..NsoLlAGAYsIushIspKLssLpsspt.....LKpKlpcuKpsScuFssKLKspHu-LGtss...soD-sAKpAILKoNss.psKGAcELccLspuV-uLhKAAptAlssulKELT.uPVhA	..................s..sSsNsADESsKGPNLTEISKKITDSNAhVLAVKEVEsLLuSIDELA.KAIGKKIcpNs..uLss-..usp...NuSLLAGAYsISo.LITpKLssLcsppt.....LKcKIpcAKKCSEsFTsKLKssHAc.LGhps...sTD-sAKcAILKTsus..KDKGAcELccL.cSVEuLuKAAp-h.LsNSVKELT.sP..............	0	1	1	1
+3222	PF01540	Lipoprotein_7		Adhesin lipoprotein	Bashton M, Bateman A	anon	Pfam-B_615 (release 4.0)	Family	This family consists of the p50 and variable adherence-associated antigen (Vaa) adhesins from Mycoplasma hominis. M. hominis is a mycoplasma associated with human urogenital diseases, pneumonia, and septic arthritis [1]. An adhesin is a cell surface molecule that mediates adhesion to other cells or to the surrounding surface or substrate. The Vaa antigen is a 50-kDa surface lipoprotein that has four tandem repetitive DNA sequences encoding a periodic peptide structure, and is highly immunogenic in the human host [1]. p50 is also a 50-kDa lipoprotein, having three repeats A,B and C, that may be a tetramer of 191-kDa in its native environment [2].	24.10	24.10	24.10	24.80	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.31	0.70	-5.38	3	40	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	3	0	2	41	1	200.70	50	99.44	CHANGED	MKKSKKIFITLCGIAATAILPVATISCNDDKLAEKNGKEKADAALKQANALAEELKKNPDYSKILETLNKEIAEATKSFKEAGSYGDYPAIISKLSAAVENAKNEKKAIDDKNAQIA......................................................................................................................KELAERNAKIQSNIEELKKINNEAFELSKTVNKTIAEVEKKFKI-ccFKEQLENFADDLLDKSRQIDEFTTVTSTQEGFTLAELESFKEITTTWFNGMKSEWARVLDAWKNELTEIN...SIIKGVEELKKLSHEISEFSNSVKKTISELEKKFKIDDKTNK-EAKpFKNELENFADQLLNKSHEIDKFVTVTSARcDFSLSELESFKSFNTTWFNEMKuEWARVQEAWKDQLKEISTK	............................................................................................................................................................A-ENtKIppGhcELhKLScchpshucTIshTIsKLE.KKFpIDcsFKcQLhSTI-.LNKKSsElcTFsTVsohKc-FlLuELESFKEhNToWhp...cIhSEWtcVpcAWpcELsEIp.............................................................................................................................s............	0	2	2	2
+3223	PF02030	Lipoprotein_8		Hypothetical lipoprotein (MG045 family)	Mian N, Bateman A	anon	IPR000044	Family	This family includes hypothetical lipoproteins, the amino terminal part of this protein is related to Pfam:PF01547, a family of solute binding proteins. This suggests this family also has a solute binding function.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	493	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.79	0.70	-6.00	3	61	2012-10-03 15:33:52	2003-04-07 12:59:11	10	4	56	0	17	843	30	438.40	27	76.45	CHANGED	MKKQLKYhFhhhGlT....hSsILTACS.SopFVlANFESYlSP.LLLERAccK+P..LTFLTYPoNEKLINGFANNTYoVAVASoYAVSELtcpGLLpPIDWAKFNLKKosNuSsp..lpNtEDAK-LFTKpIt-ISpth........KDuKNsELLcWuVPYFLQDLVFVYRGEKIsELE..pcDVoWSDVIKAIV+...HKDRF......................NcNRLlhIDDARTIFSLANIVphE..sKNNolDVN.............................................PKEsslNYFsNVYESFupLGLK+sNLsolFVN.........SDSNIVINELAsGRRQGGIVYNGDAVYAALGGDLRDElsE...NplPsGDNFHIVQPKcSPVALD.FLIINpQQopFccAAHElIa-LAL-GAD..................QTKEpLlKTDEEpGTDD........ED.aYLYGAMQNFSYVNYVSPLKsIS....DEoTGIVuKcsppADhKp.hKQpS.o-Qpo.poEKEc..............sc.aDaYTcTLKuLLp...KsDShE...........LN-psKKLV-TIKKsYpIcKs-uIp.........................WsNLlEKPIoPLQRSNLoLSWLDFKp+a	..........................................h..........hh...h.h..u..hs............h...s...h..l...o.....u.s.....t......p......s.........c.......L....V..lu...Na..ssYlsP.plh...t.E...p.tpp.h..p.s...............plsYphassNEhl...h...s....tl....+....s...s...t.....YDltlsSsYhVs+LtppshlpKIsa....SK...h.s.....l..h..tpt...s.p..t...p..........s.pthpp.hs.cphhtl.tt.......................................ps.s..plL-YhlPYahpDL.lhsap..s..ppl..p.Lp..pppl.a..phhpth..p...p.pph.............................sp.s..K.hh.l-stpp.hsl....uphhp.t......psp.hphh..............................................ht..ph.h.hss.ppht.lt..........t.hpph..ss..hhhN..........ssSs.lls.ls.tph..ts.ul.hYsGDhhaAs......sG-.....p.E.hsp.............h.stp..s.h+.lc.pso..hhD.hhl...p.....s...tp......ptAYphlpplhh.tuhp............................p...............p.................t...h......s....h.NFsaltYsss.................................................................................................................................................................................................................................................................................................................................................................................	0	10	14	15
+3224	PF03305	Lipoprotein_X		Mycoplasma MG185/MG260 protein	Mifsud W	anon	Pfam-B_4433 (release 6.5)	Family	Most of the aligned regions in this family are found towards the middle of the member proteins.	20.60	20.60	27.40	27.40	20.50	18.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.72	0.70	-4.99	17	77	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	34	0	32	75	0	232.50	27	33.10	CHANGED	LlDFuoRlAKSFsc.lps.p.sKKus-lQGVLGlDSssNsLaousFAuGsGsYsNFFapl....psupsDFsNFhNK.so.oYpNLpclaNcaKsLIspNGLalN+G.GoYoSNapKFHQLAFuloSTSGahauFAspsu.K.RLpFssps.......hpaPphT.....ppl..+sPspspp.tsh..tspstspsNLLGshslpssph.......pt.t.t.....................t....s.pspu......KsIplYKspIsssKpts.sAlL............Ipsp	.........................LlDFusRltKSFsp..p..p.sppssshpsVLGlDssssslasssFAs..usGshssF..hhpl............p...s....s..pscass.Fhs+.so.uYpNLpclasphpphlpppula....lspu..GsYoSs.atphHQhuFuIuSTuGYhasFsspsu..K..plpFspss.......hpaspho........ppl..pssspspp.tsh...t.pp..pt.psshlhphshpsspt...............p.............................t.tp...t..t.ptpt..............ch...hct....h.pttp.t........................................................................................................	0	20	30	30
+3225	PF00305	Lipoxygenase	lipoxygenase; 	Lipoxygenase	Finn RD	anon	Prosite	Domain	\N	19.40	19.40	20.70	20.00	19.00	19.30	hmmbuild  -o /dev/null HMM SEED	667	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.13	0.70	-13.09	0.70	-6.54	16	1473	2009-09-11 06:47:26	2003-04-07 12:59:11	14	34	251	68	681	1491	13	407.70	28	73.57	CHANGED	PusLhKYREEELcsLRG...-GTGchcta-RIYDYslYNDLGsPDpstp.sRPlLGGotpaPYPRRsRTGRtPTcpDPsoEpc.....s..hYlPRDEpFGHlKpsDFLshulKulsQsllPthpus...hp.hssEFcoFcDVcpLaEGGlpLP....hphlsph.Pl.hlc-lh+TDGpt...hL+assPpVlphs+ouWhTDEEFAREhLAGlNPslIcplpEFPsKSpLDsthYGspsSsITtEcLE.pLcG.hTV-EAlpsp+LFlLDaHDhhhPYlp+INs.sssKsYAoRTlLFLp-DGTL+PlAIEL.ShP+PsGc..u.sSpVahPu.-Gspu.lWLLAKAaVhVNDushHQLlSHWLsTHAlhEPFlIATNRpLSslHPIaKLLhPHaRsT.MNINuhARpsLlNusGIlEpohhsG+Yu.hEMSuslYKs.WsFs-QALPsDLlKRGlAlcDsouPaGlRLhIEDYPYAsDGLEIWsAIKoWVp-YVslYYtoD-slppDsELQAWWKElsEhGHGDtKDcPWWPKhQTp--LlcssTllIWsASALHAAVNFGQYsYuGal.NRPThoRphhPp.sTsE...a--lhps.pKsaL+TlssphQollslollElLSRHuoDElYLGpR-s.p.Wss-tcshtAFc+FGpKLp-IEccIstRNsD.sLp.NR.GssphPYTLLhPS	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tW.pD..FuhphlsGhNP.h.lp.....h.....h.....p.....................t..h..P..........................................s....t...l...............h....tt.......h..........t..............t..h........p......t.tpla..hh...D......a.....t.......h.........h.................h..............t.....h...............t.........t.........t..........................t......h......hhu..shsl.hh.....h.....p..................t......s......t.....L..hP.lAIp.l.....p.....P..............s..............................l..h.....h......P......s.............p.....s...................s........W.lA..Khas.ss-.thHp..hhsH..h...........lpTHh..h..Es..hhlAs....R..pL......s.hH.Pla+..L.L..PHhc.T.htIN..shARt.Ll......s..t.....t..........G.....h...h....-.........s.............h..................s.................u..h.p.h..th.h.h.tp...h..t..at....t....s..hPtsl.h.tRG...h.....................................l...sY.Yt.Dul.lWtsl.....pp..................alpthlt..h.aY...............s....s.....t......lttD..E..........LQsWh.p.-h........h...p...........G......h.........t...........h..............p.....t........t...s..h........p..h.po.........tpLhphhThhlahsou.HuAlNh......uQ.h.s.hhu.a.h..P..NhPs..p...P..t.............t.......t...........h.......................hts.hs..s..ts..h..h.....hh...hLu.p.............s.................l........Gp....h....t..................h.........p.......................t......httFttp.l..t.l..tt.l.thNt..t.......h..............................s.Y.hh...............................................................................................................	0	146	331	477
+3226	PF04778	LMP		LMP repeated region	Kerrison ND	anon	Pfam-B_2380 (release 7.6)	Family	This family consists of a repeated sequence element found in the LMP group of surface-located membrane proteins of Mycoplasma hominis.  The the number of repeats in the protein affects the tendency of cells to spontaneously  aggregate.  Agglutination may be an important factor in colonisation. Non-agglutinating microorganisms might easily be distributed whereas  aggregation might provide a better chance to avoid an antibody response since some of the epitopes may be buried [1].	23.60	23.60	23.70	23.70	23.10	23.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.13	0.71	-4.47	6	52	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	10	0	11	48	0	142.60	60	48.35	CHANGED	sANpLLspLsDsDscItcAKopL-pEIppANQAlsSNNsASMQSAKSSLDAKVsEITKKLETFNKDK-AKFpELEQTRKsI-EFIsss.KNNP....NYusLlppLTsK+DuKNSVTsSSNKSDIpuANsELKQALscApssKsQlDshsKSlKEQLsspIs	..............sANpL.spLoDpDspIQpAKo-L-pElpKAsQAltSNNTASMQSAKSSLDAKVsEITKKLETFNKDK-AKFpELcQTRpQIQEFINTN.KNNP.....NYS..ELISpLTSKRDSKNSVT-SSNKSDIEoANTELKQALsc.....ApscKsQsDNhsK....ShKEQLssols......	0	11	11	11
+3227	PF01451	LMWPc		Low molecular weight phosphotyrosine protein phosphatase	Bateman A	anon	Prodom_2132 (release 99.1)	Domain	\N	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  --amino -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.85	0.71	-3.85	27	7884	2009-09-12 21:07:05	2003-04-07 12:59:11	16	44	4157	78	2043	5778	2186	133.10	26	83.15	CHANGED	lLFVChGNhCRS.hAEulh+phh.t..hstth.plpSAGsp...supssc.pulplhccpGlslst+hu+plspp....hpphDlllsh.spsthtphsshhPt...hp................phplsDPh...tps....ssFcplhstIcptspphh	.......................lLFVC..h.GNhCRSs.hAEulh+phh.........................................t............t.............p.............h....plp......SAGs..........t.....t...................u....p......s....scs.t......uh.p.s........h..p............c............t......G.............l................s............h.......s...s...........p..p..u.+...p...l...s..p..p............hp...p...h...DhllsM...sp.p...ph...t..p.......l....p.t...hhPs..............hp.ph...hhtp...................................................phslsD..Pa.............h.ts...........tsF.c.....p...shc.lpptspth.................................................................................................	0	663	1320	1746
+3228	PF03548	LolA		Outer membrane lipoprotein carrier protein LolA	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.00	22.00	22.00	22.00	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.63	39	2649	2012-10-01 20:44:21	2003-04-07 12:59:11	10	3	2149	7	649	1876	1519	159.10	24	75.94	CHANGED	splpohsusFsQpshssptt...pspGphhlpRPshhRWphssPpcphlluDGcslhha-splcQs...h....htpslspoPhhLLh..psptphtppasls......tthtshhLpP+.ttssshpphplshsppsh.lpphplhDp.Gpcoplthpshp.ssslssshFpFs	..........................................................................t.thpohpusFs.Qp...s.........p........s....s..........s....h............t................................p.upGp...hhl.....p......R.....P....s........h........hpWch...s.p..P........t...p..........ph...l.l.uDGcpl..h..h...a...s....s.......p.....l.......c.....Qs.....shp.........hpp..s....h...s.....s.....o....Ph.......h...llh............tsp.ssh...p...p.a..........s...lp......................................................p......s.........t....t....p.......h...hL..s..P.....+....s......s....s..s.s......hp......p...h...pls...h........s........p......s.......s.....h...lpph...............p......hh-...p..p.s.p.p...o.s.hp..h.pshp..s.s.sl.ssshFpa..........................................................................	0	183	390	523
+3229	PF03550	LolB		Outer membrane lipoprotein LolB	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.00	20.00	21.20	21.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.87	0.71	-4.64	24	1327	2012-10-01 20:44:21	2003-04-07 12:59:11	9	2	1272	3	243	817	151	154.60	36	75.40	CHANGED	plppaphpGpluhh.....usppphuupF.Wppp.sppacLtLossLGpTtlplps..psssspLpsscGphhsussuctLlp.clhGhslPlspLt.Wl...........pGhPs...ssschplDsptpltplpp....psWplsY.pY.....pppsts.LPpplpLp.....pss........hpl+LhlspW	..........................p.lspapscGthAhh...........usp.pps.ApF.h.WQQs..tcpacLh..Lo.s.P.L.GsTtlpLss...psusspLsss.cGppYsAs-AEch.lt.cloGh..slP..lssL+pWl...........................hGl.Pu....sssch..pLD...s.p..h......+.L.spls................psWpVsYtsY......................sspsp.ss.hPpplcLs.....s..s.s........tcIKLhhcpW................................................	1	45	119	188
+3230	PF04728	LPP		Lipoprotein leucine-zipper	Kerrison ND, Coggill P	anon	DOMO:DM04880;	Domain	This is leucine-zipper is found in the enterobacterial outer membrane lipoprotein LPP. It is likely that this domain oligomerises and is involved in protein-protein interactions. As such it is a bundle of alpha-helical coiled-coils, which are known to play key roles in mediating specific protein-protein interactions for in molecular recognition and the assembly of multi-protein complexes.	28.40	28.40	28.40	28.40	27.70	28.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.87	0.72	-4.17	19	1023	2009-09-10 20:56:13	2003-04-07 12:59:11	8	1	668	20	75	206	2	55.30	64	68.34	CHANGED	SNAKIDQLSSDVQTLNAKVDQLSNDVNAhRoDVQAAKDDAARANQRLDNps.psY+K	................sA.KlDQLSS-VQTLNAKVspLosDVsAhR.......u.......sl.......p.......AAK-.......-AARANpRLDN.u.ppYpK.....	0	7	21	47
+3231	PF02169	LPP20		LPP20 lipoprotein	Mian N, Bateman A	anon	IPR002217	Family	This family contains the LPP20 lipoprotein, which is a non-essential class of lipoprotein [1].	22.10	22.10	22.10	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.99	0.72	-3.89	81	734	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	501	0	158	508	331	101.10	22	44.89	CHANGED	ss........shssspph...lhAh..............+uuphsAh+pLup..plhshplsupss...................spshhhpsspl..pstVsuhl.........+...Gscllps.h.......ssspah..s.lplc	...................................................s.spth.....hhAhG..u..................+AAph-AhcpLAp....plhGhplsupss...................lpsthhp..s..p..pl....pspVsu.h.I............+.........suc.llcp.hh.......spsh...ah.splcL......................................	0	55	103	136
+3232	PF04348	LppC		LppC putative lipoprotein	Mifsud W	anon	COG3107	Family	This family includes several bacterial outer membrane antigens, whose molecular function is unknown.	28.70	28.70	28.70	28.70	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	536	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.71	0.70	-5.95	6	1623	2012-10-02 13:57:41	2003-04-07 12:59:11	8	4	1023	1	224	1425	378	366.20	30	91.36	CHANGED	pscsNAou-hYlp+ssQoQs.p-ppsa+LhAA+lhlpENclsQApALLtcLs..sLsspQplctuLlcAcluAs+ppspsA.pQLph....sLspLSsoQpsRYacstAplhEsctDslsAsKtRIphDphLosspc+ppNtD+hWuLLpshssuVlps..ssstssssLuGWLsLsphhss.hspPsQLppolpsWpst.PpHsAAphhPstLpsLhshpQsshoplALLLPLoGshthlupsI+sGFssA+......spsssslplFD.Tssp..ol-slhsQAppsGIchVVGPLlKpNV-hLhspsQ..hQslslLALNtosNs.cu.hupLCYaGLSPEDEAcuAAs+hWsDGhRpPlVlsPQN-lGcRsssAFs.RWQphuGoc.Aslcaas.PuDlshplp..........................sspppssDuVYllAssspLspIKshLss.....stshtlYAoS+ussu..NssP-pct.LsGlpFSDIPahhsssssphp..cls.+hspuchuhhRLYAMGsDAWhLhsphsEL+tV.PGasIDGLTGpLShsssCNVER-hoWhpapsG	................................................................................................................................................................................................................................................................................................................................................................................................................................h..........................................................hh.....h..............................................t..a....h..t..............................h...........t..s.........................................................................................................................................p....hulhLP....s...G......h..t..........up....hlppGh..uAh.......................s...p..........s......s......t..l..p....l..h......D...o..sut......sh.s..p..l...ht..Q...s.p.tp.s.s...shVlGPL...+...s....p...V....p..t..L.h..t............p..tt.............................................slss.L.A...LN........t..s.......p.....s......s..........t...........h.............h....uL....u.s..pp..-...s...t..h...A.ph..h...h....t.p..t..h.p..........sh.hh.h.s.p.st...up.R.h..tsF..t.....att..s....tt........................h.....t...................p...h...t..........lt........................................................................h...s..h.hah.h.s.t...t.p.h...lhs.lt............hhss....Sp...........t.t.t........hpsl........hs.p..h.Phh..h.......t..........................................h....................................................R.h.....A.h.GhDuh...l................h.t.......h...........t..............t..th..G.oG.Lth...t...t..t....l.Rt..h...............................................................................................................................................................................................................................................	0	40	100	165
+3233	PF02684	LpxB		Lipid-A-disaccharide synthetase	Bashton M, Bateman A	anon	COG0763	Family	This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyse the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl  1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyse the fist disaccharide step in the synthesis of  lipid-A-disaccharide.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.20	0.70	-5.83	8	2446	2012-10-03 16:42:30	2003-04-07 12:59:11	10	6	2354	0	585	1902	2953	358.50	35	93.79	CHANGED	IalSAGEsSGDhlGupLlpsL+pcY.....sh+FhGluG.pMpt.pGhcsLhshcElulhGhhElLs+Lh+Lh+lhccll+phlpppsDslIsIDuPsFNlpLtK+LRKpGh+h.IIHYVuPSVWAW+spR..spplt+hsDhLLAILPFEpsaacKhs.LcspYlGHPLsDpIphpss.cspt+-hl.lspsc.hlslhPGSRcuEIp+h.hslhspAtplppphsslphlVslssscact.h.phhtt.shplshlhhsstshcuhhsuDhALhpSGTssLEsuLstoPhVVsYRl+PloaaLAKhLlKlpY..lSLsNIlhsctlhPEhIQtcschphhuhtthhhLtsspp.tcpp+stpcchpphhphtpsptccphsphh	.........................................................................................................................lhllAGEsSGDlL.Gu.sLl+AL+....t......ch.P................s.sc....FhGluGs.p..MpA...p........Gh...cuh.a.chc-LuVMGl.....l.....EVL.....t+L.cll+h..tp.clhc.ph.h.p.....pP.....DlhlsIDuPDF.Nlpltt.pL.....K.........p.....p.....G.l......c....................s......l.....+YVS.PSVWAW.R..p..p.R...............lhcIt+ssDh.lLulLPFEtsaY.c....+.......h.......s...l.s..........spalGHs.h.s..D..............t...............h..............s......h............p.........s........c.......c...........t.............s...s...+.............ph...L....ul..............s..............t............s..........t.........t.....h..lA.lLPGS.Rt.uE.lc.......hLhssFlp.....s.....u....p....hL.......p......p.......p.......h.....Ps....l.c.....h.l.l...P..h...s...s....s.....pp...c....p....h.......p.p.....h.....h........t.......p.......h.......s...s...............p.....l........s...............l...h.........l..........l.......c.........s........p..........s......p.....p......s........h.t........Au..D...suLluSGTAsL.EshLh+sPMVVuY+..h..p..s..h.o..a..h.................l...u..+..+...l..l...K.....h..p.a................lo...L.PNll.....u.....s.....c.......p....l......Vs....ELlQ.-csp....sppLut..tlh...lLt.s.s.....t....thht.h.................................................................................................................................	1	184	368	488
+3234	PF03331	LpxC		UDP-3-O-acyl N-acetylglycosamine deacetylase	Mifsud W	anon	Pfam-B_3666 (release 6.5)	Family	The enzymes in this family catalyse the second step in the biosynthetic pathway for lipid A.	20.60	20.60	21.00	20.90	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.68	0.70	-5.45	10	2676	2012-10-03 01:04:38	2003-04-07 12:59:11	8	8	2359	35	672	1850	2808	253.70	43	87.84	CHANGED	hc..Q+TLK+.VphoGVGLHoGcpspLTLcPAtsNTGIlFhRoDLss..shlPAchss..Vt-TthSTsLupc.sspIuTVEHLhAALtuhuIDNlhIclsusEIPIhDGSAtsFlhLIppAGIpEp..puscchh+IpcsVpVpcpDpaltshPssshclsaTIDFsassls+.sQthohs..hsp-uFtcpIApARTFGFhp-IEaLpspGLstGGSL-NAlVlD-.s+lLNtsGLRFtDE.VRHKlLDLIGDLhLlGpsllucahuaKoGHuLNspLl+pllsspc	....................p.Q+TLpp.lphsGlGLHoGcc.V.plTL...cP..As....s...s...oGlla.p.R.s..D..L......s............s....s.........sphsAs..sps..V..t.....-.....T.h..h..sT.sL.......ss....p....s.....s..........+luTlEHLhuALsuhGI.DNhllE.l.s.u.........s.........ElPIM.DGSAtsFlhh.ltpAGlpE.............sss.......K.........+.....al...+.I..pc..s..V..c...V........c..-....G.....-....K..a..s..c...hp...P.....h...s...........u.....apls..asID....Fs.c..P...s.Isp..Qp.hshs......hs...s.....p......s.FhcpIucARTFG......F..h.+......-...............l.....E......hLpu....tGLshGG.....S.h.-NAIV..........lD-.....cl......L.N......p..-G.............LRa.....c.D...EF.VRHK.hLDAIGDLhhh.....G.t..s.....l.lGtapuaKuGHsLNspLlctllsp.............................	0	209	429	564
+3235	PF02606	LpxK		Tetraacyldisaccharide-1-P 4'-kinase	Bashton M, Bateman A	anon	COG1663	Family	This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130.   This enzyme catalyses the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosam inyl  beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate.  This enzyme is  involved in the synthesis of lipid A portion of the bacterial  lipopolysaccharide layer (LPS) [1]. The family contains a P-loop motif at the N terminus.	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.22	0.70	-5.48	173	2466	2012-10-05 12:31:08	2003-04-07 12:59:11	9	11	2274	0	558	1911	2496	293.20	33	91.66	CHANGED	hthLLhP....lohLYuhlst..hRptha.....t.shh.pshch.slP.VlsVGNlosGGsGKTPhllhLsctLppp..Gh+sullSRGYGucsp...s..shhV.ssss............ssspsGDEPlLlAp..pss..ssVhVutc.Rspusptllptts...s-......................lIlhDDGhQHhtLt........RDl-llVlDu.....tRshGNGhlLPAGPLREPhs..pLpcsDh.l..lh.......sssps..ttt.......h...............................................thpLt..P......................h.....t...sspt.s...l.psh.h.........hAhAGIGpPp+FFsoLcp.hGhplhtspsFsDHasastp-lptltpt..p.........ll.hTEKDAVKht................................p.......hhhlslcspl.....ssshtphlhptl....p	..........................h..hlLhPlShLYuhlsth+phha.............t.hh....psh.......ch..slP....V.lsVGNlosGGsGKTPhllhLsctL.ppp........G....h...+.sull.SR..GYGu+sp................s....shll.ssps........................sstpsG...DEPlLlhp.........+ss.....ssVsVuss...Rspu.s....ctllttts.....sp............................lIlhDDGhQHh.t.L.t........R.Dl-IlllDu........hR.h.hGN.s....hhLPuGPhREshs..pLcp.s.Dh.llh.............sus.s..p..t.s..t...h..............................................................hpLh.st.h..................................................hth.t....ssptps.........h.tt.h.ph...........lAhAGIGpPtRFFso.Lct....h....G.......h.phh.............t.......s.....hsasDHpsastt-..lptlhp...t...........ll.hTEKDAVKhp.s......hst.t.................p............hahLslcspl.......ssph..thl.....t...................................................................	0	177	353	466
+3236	PF03788	LrgA		LrgA family	Bateman A	anon	COG1380	Family	This family is uncharacterised. It contains the protein LrgA that has been hypothesised to export murein hydrolases [1].	28.00	28.00	28.30	28.60	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.10	0.72	-4.29	148	3245	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	2309	0	485	1676	121	95.60	31	72.62	CHANGED	h.hlGchlsphht..lPlPGsllGhlLLhhhLh.ts.hlp..............chlctsushLLpphsLhFVPuuVGlhsahsl.ltpphh.lllslllSTllslhsouhlhp	......................hhhGphlsphhs..lPlPGSllGhllLalLLt..hp.ll.h.............caVcsuu.....shLlp.hsLhFVPsuV.ulhpahsl.lp.tphh.lllslllSTlllhlssuhss.t...................	0	117	247	369
+3237	PF04172	LrgB		LrgB-like family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance [1].	25.00	25.00	26.90	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.33	0.70	-5.19	36	3458	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	2403	0	586	1883	148	210.90	35	88.87	CHANGED	Tlhsahluphlac+h+t.hh.sPlLluhllllslLhhhs.........IsYcsYhtuuphlshlLuPA.TVALAlPLYcphchl++aahsIhsulllGulsuhloshhlA+hhuhsptlhhSlhPKSlTTPIAhtlopplGGlsslTAlhVllTGllGullGshll+hhpl+cs.lA+GluhGsuuHAlGTA+AhEhGpppGAhuuLuhslsGllosllsPllhtll	..............................................................................Tlhsahhuphlhp+h.p.....h.....hL....sPLll.uhllllsh.Lhlhs............................IsYpsYh.p...G.........up.hl.......shLLtPA.sVALAlPLYcph.c.hl+cp.a.hs....Ilsul.hlG.o.l.lu.hhosh...hlA.thhGh..s....p.pl.hhSlhP+SlTTPIAhslup.........p...........lGG.......h.s..sloAlhVlhsGllGul.l.G.thlLch...h.+I..........c................s....s......hA......+........GluhGsuuHulGTA+uh.Ehu..p.-GuhuSLuhslsG..llos..ll..sPhlh.l.h...................................	0	145	310	457
+3238	PF01462	LRRNT		Leucine rich repeat N-terminal domain	Bateman A	anon	SMART	Family	Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.58	0.72	-4.39	26	4081	2009-01-15 18:05:59	2003-04-07 12:59:11	13	511	131	66	1403	3750	2	29.00	41	7.50	CHANGED	tCP.htCpCs......spsVpCsstsLp..plPh.lP	............CP.s..tCsCs..........................sssV.pCss+...sLs...slPssIP......	0	249	354	721
+3239	PF01816	LRV		Leucine rich repeat variant	Bateman A	anon	PSI-BLAST	Repeat	The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.	21.30	21.30	21.30	21.30	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.84	0.73	-7.10	0.73	-3.41	56	206	2012-10-11 20:00:59	2003-04-07 12:59:11	12	15	101	4	120	200	32	25.00	40	14.00	CHANGED	hpVRttVAp+..hPsctLttLsp..Ds-	........tVRtsVApp.thPsphLtpLup..Dss..	0	37	87	114
+3240	PF05083	LST1		LST-1 protein	Moxon SJ	anon	Pfam-B_6166 (release 7.7)	Family	B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia [1].	22.30	22.30	22.40	24.60	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.81	0.72	-3.98	3	46	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	14	0	6	49	0	61.30	43	73.44	CHANGED	LGGLLLLsVlLLoI...................CL.......CuhSpRVKRLERutpsuG.cQEPHYASLQQLPVSSSDITDM........KEDLSTDYACIARSTPT	...........................LGGLLLLhVllL.h...................CL.......ChhppRh+tLEpsh.........t...QE.hht.L..LPs.sp.-h.th..........pED.psDYACIs.s................................	0	1	1	1
+3241	PF00677	Lum_binding		Lumazine binding domain	Bateman A	anon	Pfam-B_291 (release 2.1)	Domain	This domain binds to derivatives of lumazine  in some proteins. Some proteins have lost the residues involved in binding lumazine.	21.30	21.30	21.30	21.80	20.40	21.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.58	0.72	-4.09	20	8363	2012-10-03 00:38:56	2003-04-07 12:59:11	12	15	3923	28	2044	5873	3972	84.80	32	79.71	CHANGED	oGhlcusupItpIpcp......ssshphslphstptLpchhls.soIulsGlSLTVscls....ssthplslh.cTlp.pTshsphKlGscVNlEhs	................................oGhl-shGplh...p.l...p.p.p...................ss...s....h....p....h..pl........p..s....s...........................t....................l..t......c.......h..h..ls..uSIAlsGlsLT.V.....s.....c.....l.s.....................ss....p......Fs..l..s..l..h..scTlp..pTsL......u...p......h.....p.s.G...s.p.VNlEts..............	0	668	1327	1740
+3242	PF00894	Luteo_coat		Luteovirus coat protein	Bateman A	anon	Pfam-B_123 (release 3.0)	Family	\N	20.30	20.30	22.60	27.60	19.90	17.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.71	0.71	-4.40	13	1368	2012-10-04 01:49:40	2003-04-07 12:59:11	13	2	47	0	0	1080	0	131.00	58	53.22	CHANGED	ETFVFSKDsLsGNSsGoIsFGPSLS-CPAFSsGILKAYHEYKITplhLpFlSEASSTouGSIAYELDPH.CKhSoLuShINcFoIoKuGpKoFouctINGtpW+DSoEDQFtILYKGNGsSS.lAGSFRITI+VthQNPK	..EsFlFShDsLpuNSoGsIpFGPSLSpCPAhSsGILKAYHEYKITulplpFhScASuTouGuIuhELDsp.CK.SuLuShINpFsIoKsupKsFsAphINGpEap-o.........otDQFhlLYKGNGsoo.hAGpFhIphps.h.s................	0	0	0	0
+3243	PF02122	Peptidase_S39	Luteo_ORF2; 	Peptidase S39	Mian N, Bateman A	anon	IPR000382	Family	This family contains polyprotein processing endopeptidases from RNA viruses.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.03	0.71	-5.01	15	486	2012-10-02 13:45:52	2003-04-07 12:59:11	10	4	34	1	0	526	2	164.30	35	39.72	CHANGED	VcGapoaslPpsPPKsuVlplp+ssGoHsGYAoC...lpLasGpsuLlTutHslsc........sttstSh+sG..sKIPL..s-F+slhcssptDlslLpGP.PNWEuhLuCKusphsTsspLu+usAohashccst.WhussAc....IsGs....p..sp.assVLSNTcsGaSGoPYFsGK.sllGVHpGt...sscscNaNh.MuPIPslsGLTSPsalaEoTuPpGcl	.........................pGhh.aphspp.scasV.thh.PsDp.ht.Aos.....s.h.ssEcAhhsu.ts.sp.........s.t..s.c.ph.+ss....phPL...sE.p.h...L.....s..s..hhs.ll.phs.sphtshlttKhh+.t.spp.....p..pushp..hh.....cp.....h..psuc.....s.ts..p..sh..ssVh..S.p..s.pts.hussPhash..p.htsHpG....uppsppap..huPlssh.....Pp....ss..p....................................	1	0	0	0
+3244	PF04662	Luteo_PO		Luteovirus P0 protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_4444 (release 7.5) & Pfam-B_3579 (release 10.0)	Family	This family of proteins may be involved in suppression of PTGS a plant defence mechanism [1].	26.60	26.60	27.00	45.30	24.60	26.50	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.09	0.70	-4.87	8	137	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	22	0	0	137	0	208.60	35	86.25	CHANGED	llsp.sRpLhsp-RshhsutFLhphshhlsh..............t....cspthlRSlLatLPLLL.....sG-hhassuthph.h.....LsRaultsGhsPsso.........psslcLplPuocsshRhhLtRssoouLuE+lpRap-sLt.pGhcpFp+FLssahpshERpLscsshcsshssphhl-LssLGstLtchVhspplhppuhhoclAhthp+laGEssuls	........................lhlppsRhLhhcpcshlhuhhLlsItphlph...........h..t.st.p.l-hhlRSLLatLPLLl........Gct..lasssthph.h.....hscFuLhsGhtPsso.........sttlcLclPsTc.suhRphLtRssuSshuE+hpRhsEshh.puhEtFpRhLusahcptERplhpustc..hGscphl.LusLGphLtchVsspphpppshhuclAhthp+laGEstuh.................	0	0	0	0
+3245	PF01659	Luteo_Vpg		Luteovirus putative VPg genome linked protein	Bateman A	anon	Pfam-B_970 (release 4.1)	Family	This family consists of several putative genome linked proteins.  The genomic RNA of luteoviruses are linked to virally encoded genome proteins (VPg).  Open reading frame 4 is thought to encode the VPg  in Soybean dwarf luteovirus [1]. Luteoviruses have isometric capsids that contain a positive stand ssRNA genome, they have no DNA stage during their replication.	25.00	25.00	26.80	49.70	24.10	18.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.09	0.72	-4.34	8	687	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	39	0	0	510	0	103.60	47	67.26	CHANGED	l.h.E-QAphRHSaSQRTsS+sTPpEVSsSGRlYQsApHSpMEYSRPTMsIRSQsShaSSSsRPLP..sVPSLhshT.sApspP.ssp.hsStStpsspcsSphp	.......hh-ppAshRaSaSQpTsS+sT..tpSsSuRlYpsAQ+SphEYS+PTMsIRSQVShaS.StpP.P.pps.SLhshT.pAssp.asspLIsSsSt+hs.psSp..t......	0	0	0	0
+3246	PF04443	LuxE		Acyl-protein synthetase, LuxE	Kerrison ND	anon	DOMO:DM04138;	Family	LuxE is an acyl-protein synthetase found in bioluminescent bacteria.  LuxE catalyses the formation of an acyl-protein thioester from a fatty acid and a protein.\	      This is the second step in the bioluminescent fatty acid reduction system, which converts tetradecanoic acid to the aldehyde substrate of the luciferase-catalysed bioluminescence reaction [1] A conserved cysteine found at position 364 in Photobacterium phosphoreum LuxE (Swiss:Q52100) is thought to be acylated during the transfer of the acyl group from the synthetase subunit to the reductase.  The carboxyl terminal of the synthetase is though to act as a flexible arm to transfer acyl groups between the sites of activation and reduction [2]. This family also includes Vibrio cholerae RBFN protein (Swiss:Q06961), which is involved in the biosynthesis of the O-antigen component 3-deoxy-L-glycero-tetronic acid.	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.34	0.70	-5.77	7	387	2012-10-02 15:58:18	2003-04-07 12:59:11	7	5	327	0	124	413	321	321.20	24	83.12	CHANGED	Ms....lcppplhuSoElDDlIF.upP.phoh-EQcplpp+llhpua.aHYppN-pYRpaCpsptVs..-sl...ps..IsDIPVFPTSlFK.....a..t+LhTss--cIEsWaTSSGTSGlKSplAR...DRlSIERLLGSVsaGMcYVGsaa-HQhEL.lNlGPD.....RFNusNIWFK....YVMSLVELL...YPTs..FTV....spDc....IDF.EpThtpLhpIppptKslCLIGsPaFlYLLsp..a..hK-psIp.FpuGpchaIIT.GGGWKppps-u.....LcRt-FNphLh-sFpL.s.sQIRDTF...NQsELNTCFFED...php++....HVPPW..VaARALDPcTLcPlsc.Gp.GLhSYMDASuTSYPuF....IV.TDDIG.Ilcc..pps-..asGspVEIlRRlpTRttKGCulSMspshp	...................................................................................h....................................t....htthhhp.htap...appst.Y.+paspt....t.hs.....tpl.....ps...lp-...I..PhlP...lph...FK........t...tpl.h.oh.s......p.p..p.l.p.t.h.h.p.SS.G.T.....o..G......h...t...S..p...h.hh......D.p......s.ht.t.....t..s..hth..hh..p......h...h..t.....p..t....h.t.h..ls...h..t..P.s..........p.t..s.s..h.h.h.p......h.h.h....hs.....hh.......hs..sp.....ahl.......ptp.t..........h.c.h..pthhttl...p..tt..pspslhlhG.sh.hh..ah.h.h....h...hccp..shp...h.pl...s...t.s.shlhc.sGGaKthppc......ls+pphpphltpshGl.....pphhsha...s.sE..h...s....hhcs...........sttth............p..s..P..sa....l..h..hR.....D.s.p.s.h...p.s.hs.....G..c.h.........Gllphhshhsh.s.suh....ll.T.-DlG.hltt....ss.....s.h........FcllGRh.ptu-h+GCu..........h....................................................................................................	1	47	90	108
+3247	PF02664	LuxS		S-Ribosylhomocysteinase (LuxS)	Bashton M, Bateman A, Adamkewicz J	anon	COG1854	Family	This family consists of the LuxS protein involved in autoinducer AI2  synthesis and its hypothetical relatives. S-ribosylhomocysteinase (LuxS) catalyses the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule. 	20.20	20.20	21.00	21.00	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.67	5	2731	2012-10-02 15:41:56	2003-04-07 12:59:11	10	2	2619	23	302	1250	26	152.40	46	95.62	CHANGED	Ppl-SFslDHTKlsAPhVR.lAc+KsTscGDlITsFDlRFCtPNKE.lMcscuIHTLEHLhAshlRNHtN.hssh-IIDISPMGCRTGFYLollGcPspp-llDllcsoMpDVLclp-..pIPuuN-KQCGsYppHoLEsA+clARsaLs+..tI...KsEpLcls	..........................l-SFplDHT+hpAPhVR.lApphpsP.+G..DsIosFDlRFstPN+-.hhsptGlHTLEHLhAshhRsHls.u...clIDlSPMGCRTGFYhslh.Gp...s..sppclscshcsuhcD.lL.p..s..p...s...clPthN..hQCGsYp.HSLptApph.A+plLpp...tl...ps-.....s.............	1	74	166	239
+3248	PF00206	Lyase_1	lyase_1; 	Lyase	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	21.20	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.71	0.70	-5.24	18	16439	2009-01-15 18:05:59	2003-04-07 12:59:11	15	45	5117	204	4142	12313	9223	297.30	26	66.01	CHANGED	GchssssDthhuhhopcsh.sh+lst.s.p.......uhshhp+AtApssh.h....pctssuIhpuh-clhc.schscpFslsshppsssTssphplsElIu.......t.........csss+VppupSoNDshsTuh+lhhtpslpp.LlstLppLhpslsc+AcpatDllhhGRTHLQcApPlTlGpchpuasttlpc-hpRlppsh.chhhtshsGGsusGTulNsc..ch..hlsccLu...hou....sssNph-Alus+DtllEhhuslshlsspLtKh.ApDlplhuSG..sGhsElshstsp...GSSlMPtKhNPsssEh...lpthuspVhG	.............................................................................................................ht...ssthhth.o..t..ps..h.....p..h.....h.....lt......ph.............s.hhh..t.p.u..huth.sh..............................tp.sp.tlh...p.u.h..c.p...l..h..p.....h.p......h..t.........t....t....h....l...p.h.h.p..p.s.......s...t....p.....s..s...p...h...p......l.s.E.h..lu........................................................p.s..sc.clphup.So.........NDh.....h..s.Tuhp...lhhtpsl.chlhst....l.p.p.L.h.psltppAp....pa......p..c..hl.....hhGRT..H.h....Q..c...A.pPhThGpchtuas..t.l.p+...s.hp....+.lppsh....p.h.............h.h....t.h..ht.G....u.s...u......s.........G.....T......u........h.............s.......h........s.....................t.....................t...........h.s..s..c....pLu...................h..s.s.....................s.t.s.........h..h.........p...s..l....s....s+.D.h.h......s..c.....h....h..u.....s.lshlu....s..pLp+lupDlhh.hsos...huhs.El.s......h.st.s.p...G.SSl.MP.t.......K.hNPs.hsEh.....lpthshplhG..............................................	0	1294	2586	3471
+3249	PF02278	Lyase_8		Polysaccharide lyase family 8, super-sandwich domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_4840 (release 5.2)	Family	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	20.00	20.00	23.30	20.40	19.40	18.90	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.84	0.70	-5.03	5	1067	2012-10-02 23:57:29	2003-04-07 12:59:11	13	57	784	47	126	780	15	260.60	32	28.72	CHANGED	scP..stL+tFNsMDRlsaaNt-huFuFGLSMsSKRTt+YEuhNcENhRGWYTGDGMhYLYN..oDssHYoDtFWPTV-hYKlPGTTspDs+psDs.Tc-.............tpsss.oscauGo.KlDDpaAuuuMDFcNhscTLTA+KSWFhLcDKIVFLGoGIpsTsssssssTTIDsRK.tsssuYssYsscKphohscup.....-spSVFLESa-s++NIGYaFhcsusIolp+csQTGsWp-IN.sSpocccVos-ahTloQcHusc..sssYGYhllPGlsRssFs	............................s.....p.hpha.spMD+hshhp...t.....s..auhuLShhSpR..ltsYE......t.h..N.s.E.Nh+GWaTusGMhY.LYs.....sD..h.s.c...Y.....p-....s..a....W..s..T...sD.h+lPGTTs....h....s...s...p...hs..cs....sss........................................t.t..hps...p...s..huGu....ph....s.s.......p..h.us.h...u.....M.......c..a......s...............s............................s...........p..............o................L....s..A.....+......KSWFhLsDcI.l.h.LGosI...p.........s..s.s.......s........p...s..s...............t.To.l.-.p....R+................s.ssh.pl..h.s..s.s....t.p.h..s...s..p..pp...............................psp...l.h..h....p....s......t..s...s..p...p..s..l.G...Y.a..F.h.p..p.....s.....s.......l.sh.p.pppp.......pGpWp..-I..N.....p..u...p....s....s....c......p....h......pspahplt.sHsps.......sspYuYhllPshspt........................................................................................................	2	69	106	120
+3250	PF02884	Lyase_8_C		Polysaccharide lyase family 8, C-terminal beta-sandwich domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_4840 (release 5.2)	Domain	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	20.20	20.20	20.20	20.20	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.06	0.72	-3.96	29	875	2009-01-15 18:05:59	2003-04-07 12:59:11	12	50	698	45	82	585	8	76.70	25	8.46	CHANGED	lplLpNssphQuVpcsp........slhussFa.ssu......psst...lssspsuslhl+cpsss.hplslu-Pspsssshp...............plh	.........................hpllcNscslQuVccsc........slhuhsha..ssust........pssp.....l.pl.p....ptu..hhhl.+......cp..ssp..hcluhh.sPppppss.s...hh...........................	0	46	68	79
+3251	PF00062	Lys	lys; 	C-type lysozyme/alpha-lactalbumin family	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.91	0.71	-4.14	21	1035	2012-10-03 00:09:25	2003-04-07 12:59:11	15	9	315	768	356	1346	9	110.30	37	77.66	CHANGED	KhasRCELu+pLKt.GhDGYpGlSLusWlChspaESuYsTpAhspN..ssSTDYGIFQINs+aWCscucTPtupNhCsIsCspLL-DDITcslpCAK+Il.DspGlssWlAW+shCp.cDLspa.tsC	...................................................................hhpRCELActLp.t...shs.att.pLssW.l.Cls.aESuasTpshs.......tss...sG.S.s-Y...GlFQINs+aWCp...s...sp..h.......s.......t.............shCpl.sCs...t.L...Lsc-lscsltC.A+p.Ih.p.....t.......p.......G.......h.......puW..........sWpt.hCp...pplsph.ttC..................................................................	0	50	75	177
+3252	PF01810	LysE		LysE type translocator	Bashton M, Bateman A	anon	Pfam-B_1537 (release 4.2) & Pfam-B_7916 (Release 8.0)	Family	This family consists of various hypothetical proteins and an l-lysine exporter LysE Swiss:P94633 from Corynebacterium glutamicum which is proposed  to be the first of a novel family of translocators [1]. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times [1]. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of  l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.14	0.71	-5.02	19	13176	2012-10-03 02:02:08	2003-04-07 12:59:11	13	5	2968	0	3080	9500	5031	188.60	20	91.83	CHANGED	lshhhsPGPsshhlhppulp+uhttulhsshGshluDhlhhhlshhGluhllt.sshhhsllthhGusaLhahGhtshRsshpsps.pt..........................tssp.........thhpsahpGlhloLsNPpslLaahulhushls....tht.hthhhhhsuhhlusl.lWhhhluhhsuhhthhhpt.th...hlshlsuslh...................hhFulhLlhpu	...............................h..hhlsPGPss.h.hlhpp....u.l......p.....p.G.....h...p.tuh....hs....shG.h.sh.G.....h...l...h...h...h.hu...s...h...G...l..us...l..lt...t...s.s.h......l.h.p...l...l..ph....s.G...u....s..YL....l....a..lG....h...p.h....h.....+....u........s.......h...p.....t.....p...t...t...t.t..................................................................................t.tst...................shhp..h..a.hp..uh...hss...l.h.N.....PK.s..h...l.a.h...lu.l...h...s..p..h..lss.....................t..s..h...h....t...h....h....h......h.....s..h...s......h.....h.....h.......s.....s....h......h....a....h.....h......h......h....u.......h....h....u...s...h....h......t....t....h....h...p....p....t....p.hh......phl.s...t.l..h.G.s.lh...................h..h.huhhlh...t........................................................................	0	649	1498	2340
+3253	PF03641	Lysine_decarbox		Possible lysine decarboxylase	Bateman A	anon	Pfam-B_741 (release 7.0)	Family	The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.77	0.71	-4.34	32	5042	2012-10-01 21:16:48	2003-04-07 12:59:11	9	29	3532	56	1524	3863	1410	131.70	28	49.24	CHANGED	Msslscush..cuGup........slGlhsphlhs.pchs........................sptls-l..lhhpshapRKthhschu-AFlshPGGhGThEElhEllThhQlGhc...p+.PllLhs.su...aacsLhpalc.phlppGhlsssstp.hhhhsssscplhptl	...........................................................Mtusscush.......cu.u.u.p...........slGl..h....shlls...p.chs.......................................................ss...h..l...s...c..l.......lh..h..p..s..h..p.p..RKt.hhs........c........h........u........c.u.h.....lsh.P.........GG.hGT.......l-El.hEhloh..hQh.shp.....................pp...P..l...l.Lhs.st..........aaps.L.h.pa..l...p..thh..t.p..u...h...lstpshp..hhhls-ssp-lhp..................................................	0	441	972	1290
+3254	PF02402	Lysis_col		Lysis protein	Mian N, Bateman A	anon	Pfam-B_1555 (release 5.4)	Family	These small bacterial proteins are required for colicin release and partial cell lysis. This family contains lysis proteins for several different forms of colicin. Swiss:Q02112 has been included in this family, the similarity is not highly significant, however it is also a short protein, that is involved in secretion of other proteins (Bateman A pers. obs.). This family includes a signal peptide motif and a lipid attachment site.	25.00	25.00	57.10	57.00	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.32	0.72	-4.38	9	52	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	28	0	2	37	0	45.10	67	96.50	CHANGED	MK..Klhhhhlllls.hhLuACQANYIRDVQGGTVAPSSSucLTGlulQ	..MK..KlhhlhlLllu..hhlLuACQANYIRDVQGGTVuPSSSuELTGlusQ.	0	0	0	2
+3255	PF04971	Lysis_S		Lysis protein S 	Finn RD	anon	Pfam-B_7633 (release 7.0)	Family	The lysis S protein is a cytotoxic protein forming holes in membranes causing cell lysis. The action of Lysis S is independent of the  proportion of acidic phospholipids in the membrane [1].	20.70	20.70	20.80	21.00	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.17	0.72	-4.29	7	1200	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	353	0	16	366	0	66.40	84	94.47	CHANGED	M-KITTGVuYsTSAsusGYWFLQhLD+VSPSQWAAIGVLGSLlFGLLTYLTNLYFKI+EDRRKAARGE	....................................MEKITTG...VSY.sTSAsGTGYWhLQLLDKVS.PSQWuAIGVLGSLlFGLLTYLTNLYFKI+ED+RKAARGE..................	1	2	5	9
+3256	PF01186	Lysyl_oxidase		Lysyl oxidase 	Finn RD, Bateman A	anon	Prosite	Family	\N	20.30	20.30	20.30	21.50	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.49	0.71	-4.70	4	515	2009-01-15 18:05:59	2003-04-07 12:59:11	12	16	109	0	231	428	15	188.90	54	36.67	CHANGED	PDLV.DsthVQtosYlpctsLa.LpCAAEENCLASSAhRssshsYspRhLLRFspRl+N.GpADFhPptsRaSWpWHpCHpHYHSMD.FoHYDLLsssus.KVAEGHKASFCLEDTpCs.GhhKRYACssa.pQGlSsGCaDTYptDIDCQWIDITDV+PGNYILpVpVNPsa.VsESDFoNNlhRCsh+YsG++laspsC+Iusu	...................................................................PDLV.cs.hlQto....sYlpchsha.LpCAt.EENCLu...u.....SAh..p....s....p...........h.s.....Y..s....hRhLLRFsppl+NtGpuD.F...h...P..p.tsR..asW.WHpC..H..p...HYH.SM-.FoHYDLLshssp.....KVAEGHKASFCLEDT.p.....C...........c.....Gh...p+..........R.............Y.........s..........C.s.s.....a..............p...Q.G.......losGCaDTYptDIDCQWIDITDVp.P.G.s.Y.ILp...............VslN..P....papVsESDaoNNsh+Cph...+YsGp....h..h..h..h.sCphs...............................	0	40	63	139
+3257	PF02401	LYTB		LytB protein	Mian N, Bateman A	anon	Pfam-B_1515 (release 5.4)	Family	The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. The LytB gene is involved in the trunk line of the MEP pathway.	18.70	18.70	19.10	19.20	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.86	0.70	-5.49	13	3664	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	3349	24	911	2662	2891	277.30	42	82.28	CHANGED	IlLApPRGFCuGVcRAIphsEpA.Lppttu.PlYlpppIVHNppVVspL.RpcGshFlEsl........p-lP..........cGshVIaoAHGVuspVcptAccRsLpllDATCPhVTKVHptspphu+cGaclILIG+csHsEVhGshG.ss.........................spshlVpshc-ltpLshps.p+luhloQTTloh--st-IlstLccRascltt.........spssIChATpsRQcAl+sLutcsD.lllVVGupNSSNSsRLhElApcpGs.suaLl-ss-.................-lpt-Whpssp.slGlTAGASTP-hllpsVlp+Lpph	..............................................llLAsPRGFCAGV-RAIp....l.......V..Ep.....A........L.........c.........h.....a.............s.............s....PlYV++ElVHN+a.....VV-sL.c.p.+.G.sl..F..l...-..cl..........s-lP.......................................cs.s..h.VIFSAHGVo.sVppcAc.p......R....s.L..p..l..h..DATCPLV.......T....KVHhcl....t....+............h......sc...........c......G...........h....clllIGH.t.GHPEVcGThGphs........................................sth.h...L....V.......-.......s...s.....-.....D.......l.........t.........p.........L.......p.........l....p....s.........p..c..lshloQTTLSlD-Ttc.llctL.+p..+..a.P.p.lhs...............................Ph.pc-ICYATpNR.QcAV.......+.p..l....A.....p..p.......s......D.....lllVVG.upNS.SNSsRLhElA.pc................h.......Gt....su.aLl-ssp.................................-l....p....p..Wl.....p.....s.....s...p......sl..GlTA.....GASsP-hLVppVlsplpt.h...............................	1	319	613	776
+3258	PF04397	LytTR		LytTr DNA-binding domain	Yeats C	anon	[1]	Domain	This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern (see [1]). 	21.50	21.50	21.50	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.83	0.72	-3.92	114	8937	2009-09-11 13:50:36	2003-04-07 12:59:11	10	26	2937	3	1808	6179	571	96.10	22	42.29	CHANGED	sphhhlshp-Ihal..ps.pschlplhst.....spphhh.ptoLpplcpcls..stFhRsHRShlVNlppIpclp.......t..ph..plhhps.....spplslSRphhcpl+phlt	............................................p..hhhlshp-Ih.ah........ps...p.....s...c..hl...h....l...hop............sp....p....h....h.h....p..h.....s.L.p.....p.....l.c...p.....p.....L....s........pp.......F.h.RsH+Sa.lVNhp.plpplc..........................ph...pl....h..lps.............sppl..l..SRphhcpl+phh.t...........................	0	766	1373	1637
+3259	PF02370	M		M protein repeat	Bateman A	anon	Pfam-B_208 (release 5.2)	Repeat	This short repeat is found in multiple copies in bacterial M proteins. The M proteins bind to IgA and are closely associated with virulence. The M protein has been postulated to be a major group A Streptococcal (GAS) virulence factor because of its contribution to the bacterial resistance to opsonophagocytosis [1].	20.80	15.60	20.80	15.60	20.70	15.50	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-7.31	0.75	-7.27	0.75	-2.86	59	653	2009-09-11 13:49:06	2003-04-07 12:59:11	11	24	24	1	3	651	0	21.10	53	14.87	CHANGED	ptK+plEuchpcLppcpptlc	..EAKKclEA-htcLpp-pQh.c..............	0	0	0	0
+3260	PF03855	M-factor		M-factor	Finn RD	anon	DOMO:DM08003;	Family	The M-factor is a pheromone produce upon nitrogen starvation.  The production of M-factor is increased by the pheromone signal. The protein undergoes post-translational modification, to remove the C-terminal signal peptide, the carboxy-terminal cysteine residue is carboxy-methylated  and S-alkylated, with a farnesyl residue [1].	25.00	25.00	28.40	83.80	22.30	16.60	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.19	0.72	-3.97	2	3	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1	0	3	3	0	42.30	72	100.00	CHANGED	MDShAssspSSSlVNAhNp.Ps-slp.pslKNYTPKVPYMCVIA	MDSMANoVpSSSVVNAGNK.PoETLN.KTVKNYTPKVPYMCVIA	0	3	3	3
+3261	PF05034	MAAL_N	MAAL; 	Methylaspartate ammonia-lyase N-terminus	Bateman A, Moxon SJ	anon	COG3799	Family	Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the N-terminal region of Methylaspartate ammonia-lyase. This domain is structurally related to Pfam:PF03952 [2]. This domain is associated with the catalytic domain Pfam:PF07476.	21.00	21.00	21.40	36.90	20.00	18.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.79	0.71	-4.46	4	186	2012-10-02 11:54:41	2003-04-07 12:59:11	8	4	173	12	42	142	2	155.20	62	38.70	CHANGED	M+IccVLhTPGhuuFaFDDQtAI+sGAspDGFsYsGsPsTsGFpplRpsGEulSVtLVLpDGpVshGDCAAVQYSGAGGRDPLFhApcahsllpctltPtLlGRDlssahssAthh-ch.lstptLHTAlRYGlSQALLcAsAtsptsThsEVlsDEash	..MKIKpslhTsGhouFYFDDQpAIKsGAsHDGFhY.sGcPVTtGFsuVRQAGEslSVtLILEsGuVAhGDCuAVQYSGAGGRDPLFLA-cFIPhlpccI+PhLlGRDlcuFhssAchFDcL...+l.........D...Gp.hLHTAlRYGlSQALLDAsAhAs.s+hhsEVVsDEap................	0	16	27	36
+3262	PF03281	Mab-21		Mab-21 protein	Mifsud W	anon	Pfam-B_4530 (release 6.5)	Family	This family contains Mab-21 and Mab-21 like proteins.  In C. elegans these proteins are required for several aspects of embryonic development [2-3].	20.10	20.10	21.30	20.50	19.10	19.80	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.92	0.70	-5.28	33	746	2012-10-02 22:47:23	2003-04-07 12:59:11	9	9	110	0	456	647	1	241.40	20	57.39	CHANGED	uhh-slcltssscach.........hh.lpt.shhp...................hppptphsshshl+l.............................hps.phhpcals........................tsshlssp+lhstFt.sllppu...............................lsphphps............h.phttpssslpltlppt.........thslDllsulch.shWPp.u.pa.hh.............phWPs.thhpplts..pGhaLls+.........................................tshsshpWRlSFopuEptLhpph............sss++cClpllKtlpcphh...........hsslsoYHLKTllhapC-+hPpt..pWpp.sslupplhsllccLhpCL....ps+plPHYFlP.....phNLhpsh..spstlpphspplhclhp	......................................................................................................................................................................................................................................................................................................................................phh................................................................................................t.hhsst...phhphh..ph..lt.s..................................................h.p..t.t.................t...ts....hpl.ht.............h.hplhPshph...........t................................................sh.Llst.......................................t..t.t.pss.tWhluFstsEptllp.h............sus+.hpsLpl....h..+s..l.tcpth.............................thtsls.sYHL.+ollh..ahspch...st....p....Wpp......ptlupph.tll.tLhpsL....................ppcp..hspaahs..................phshhpth....tth..hh........t...............................................	0	90	123	236
+3263	PF01823	MACPF		MAC/Perforin domain	SMART	anon	SMART	Domain	The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerisation of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerises into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin.  The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (Pfam:PF01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold [1]. 	20.70	20.70	20.80	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.30	0.70	-4.64	69	1344	2012-10-01 20:08:01	2003-04-07 12:59:11	14	63	273	9	771	1199	5	197.40	16	29.28	CHANGED	hshsssspa.pph........phpppppphhhtpspsphhphph...ts.ph........LsppF.....hptlppLPsp.as.sp.............................ahphhcpaGTHhlspsphGGphthhhph.......spsplpptphpttc............hssthth.h..................thphptstpspppppppp..s......ppthppthshlhGGss................tsspsappWtpolpp.pP.ssIphp.....................................lhPl....ppLlpp...............tppslppAl...ppY	.........................................................................................t.......th.pt..........t.tppp.p..h....h....h...th...h...p....hh.p.hph........p.pph..................LstpF.....hptlpp.L....sp.p...h.s.st...........................................h..phl.ppYGTHal.ss.ss.h..........G.......Gphphhhhh........................sppp...hp.p.pthptt.p...................hpht.hth.h..............................ht.p.hstp....tt....t..p......tt....t......................................pt....p.h....hh...GGp.................................thppW...hpolt........t..tP...hlp..h.p....................................................h.Plhpll.....................ht..hptAh...........................................................................................	1	245	380	547
+3264	PF03523	Macscav_rec		Macrophage scavenger receptor	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	45.90	44.70	23.80	18.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.30	0.72	-4.21	4	55	2009-09-11 06:31:35	2003-04-07 12:59:11	8	6	27	0	17	49	0	48.90	75	13.96	CHANGED	MEcRIQ.ISDocANLlDoE+FQNFShTTDQRhNDVLLQLNSLlsolQtH	....MEKRIQaISDhEANLIDoEHFQNFSMsTDQRFNDlLLQLSTLhSSVQGH..	0	1	1	2
+3265	PF03817	MadL		Malonate transporter MadL subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	27.90	27.70	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.67	0.71	-4.27	4	182	2009-09-11 09:12:09	2003-04-07 12:59:11	8	1	176	0	51	151	39	121.60	57	91.51	CHANGED	MIIYGVALLulCpLsGlhlGshLGshLGVKANVGGVGIAMlLLIhspphLtK+GtLsphop.GVtFWuAMYIPIVVAMAApQNVluALsGG.lALLAuluAllVshhhIslls+.u..puph.sAlE	.MIIYGsALLAlCpLAGlhlGDlLGshlGVKuNVGGVGIAMlLLIhh+haLp++Gh.hspcoEtGVuFWuAMYIPlVVAMAApQNVVuALpGGPlAlLAuluuVslCsssIslLuRhu..+tps.....t................	0	9	20	35
+3266	PF03818	MadM		Malonate/sodium symporter MadM subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	59.60	59.60	20.50	19.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.77	0.72	-4.40	4	185	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	183	0	51	137	41	59.80	57	23.68	CHANGED	a-.lsssLspNGLITuFAllGlhMaVSahLSthLT+G+lHGSAIAIhlGLVLAYVGGssT	......-hlpKsls+NGLlouFAlVGllMalSshLS++LThGRVHGSAIAIlIGLlLAYhGGshT...	0	9	20	35
+3267	PF02545	Maf		Maf-like protein	Mian N, Bateman A	anon	COGs	Domain	Maf is a putative inhibitor of septum formation [1] in eukaryotes,  bacteria, and archaea.	19.40	19.40	19.60	19.70	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.13	0.71	-5.19	12	5338	2012-10-01 20:37:09	2003-04-07 12:59:11	9	24	3690	6	1449	4011	3017	188.60	33	91.91	CHANGED	h.llLASsSPtRpplLcpht..lshpshsuph-Ep.....tp..PtthshcLAppKAhu.luphtss...........sllluADTllhls.GclhsKPpst-cAhphL+phuGps...tpVhTulslhpptp.hpsh.....s.TcVpFpp.lscccIpsYlpos-slcpAGuaslpGhGuhhlcplcG.sh.sVhGLPl.tlhphLpphsh.........hts.h	..............................................................h.pllLASsSPtRp..pL.L.p.p.l......G.........l.s...........F.p.h....h.........s.........s........c.......l........D.Es................h.s...-.......t.........................P......p........p...h...........V...h.....+.....LApt.K.A.p..u..........l.s..p.h..hss......................................................tlllGuD.ol........l.s..............l.................s.....G..........c.......l....lG.KP......pstc...cAtp.....hLp......t......h.......S.G..pp...........apl..hT..u..l....s..l...h.....s...s....p.....p..t....htph......................shocVpF+p....Lo...-p...-...I...p...s....Ylt..s..s...-..P..h..c.pA..Guasl..p.G.h.G.s.t.h.l.cc.l.p..........G..shpsllGLPLhphh.ph.Lpp.s........t..................................................	2	469	903	1204
+3268	PF02792	Mago_nashi		Mago nashi protein	Bateman A	anon	Bateman A	Family	This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [3]. The human homologue has been shown to interact with an RNA binding protein Swiss:Q9Y5S9 [1]. An RNAi knockout of the C. elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination [2]. Mago nashi has been found to be part of the exon-exon junction complex that binds 20 nucleotides upstream of exon-exon junctions [4].	20.10	20.10	22.60	22.10	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.64	0.71	-4.50	3	383	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	275	17	226	307	1	132.20	69	83.18	CHANGED	DFYVRYYVGHKGKFGHEFLEFEFRsDGpLRYANNSNYKNDTlIRKEsFVSEuVLKElKRIV-DSEIlKEDD-NWPEPDKlGKQELEIlhsNEHISFsTuKIGSLADVQNScDPEGLRlFYYLVQDLKCLVFSLISLHFKIKPI	...........................................................pFYLRYY...lGH+.............GKFG.HEFL...EFEFR.....s..DG.....+...LRYAN..N....SNYKNDshIR...KEs..aV.ppuVhcE.lKRII.c-....SE........I..hK.......EDDshWP.PD+..l.GRQELEIllGsE......HISFTTo.KIGSLlDVspScDPEGLRlFYYLVQ.DLKCLVFSLIuLHFKIKPI.......................	0	80	120	175
+3269	PF03082	MAGSP		Male accessory gland secretory protein	Bateman A	anon	Pfam-B_256 (release 6.4)	Family	The accessory gland of male insects is a genital tissue that secretes many components of the ejaculatory fluid, some of which affect the female's receptivity to courtship and her rate of oviposition.  This protein is expressed exclusively in the male accessory glands of adult Drosophila melanogaster. The proteins are transferred to the female fly during copulation and are rapidly altered in the female genital tract [1].	25.00	25.00	115.50	47.80	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.82	0.70	-5.00	2	35	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	7	0	1	123	0	235.40	77	99.83	CHANGED	MNQILLCS.ILLLhFTVAsCDuEpQLDSuhcL.....KSAsLKNVAPKNstTQAcIsKDDVALKsuKKGDYlMDI-lSDhPLDDYPINpSKShKsSSh..ssI.....LsD....chNQGSNQ.ALKALppRLlhEQNNsLhLRNHSl.LMpEIEARKTDIIpsRQLNlDLELELpolpR+L.EhN..lQNsRKSTKsCKKRsSKD.APP.sNQhQEs.V+NTYRNKYLTLLppLuQKIN.EIApV...ATDVPTtpsPSpGN.sTh	...................LhFsVANCDGEHQLDSSl.D..L..K.S.DppKSAVLKNVAsKNDATQAEIAKDsVALKSGKKGDYVMDI-.V.SDMPLDDYPINNSKSRKNSSTLPSP.I.....LTD....KLNQGSNQIALKALKHRLVMEQNNNLFLRNHSVSLMNEIEARKTDIIQARQLNIDLELELEALKRKLSEMN..VQNARKSTKSC.KKRPSKDIAPP.sNQLQEVIVKNTYRNKYLTLLTQLAQKINYEIANVNNPATDVPTGKSPSEGNPSTT...................	0	1	1	1
+3270	PF04112	Mak10		Mak10 subunit, NatC N(alpha)-terminal acetyltransferase	Wood V, Finn RD	anon	Pfam-B_9176 (release 7.3);	Family	NatC N(alpha)-terminal acetyltransferases contains Mak10p,  Mak31p and Mak3p subunits.  All three subunits are associated  with each other to form the active complex [1].  	20.70	20.70	20.80	22.90	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-5.03	18	303	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	263	0	218	301	3	149.50	30	21.95	CHANGED	+sGcLV+-spFsLF-uhuAlEIh-sKMDoGhlt.s.pt....tlcpuhssu.........pslshtclluIhDpLhss.huWhpGa.oLuQTVhoClYlcpl......t...t.............................ssplhcpVLpuaslulhphhshltshlpsutlaEE..EDhsspshshshhsphs.htchhshL	........................GcLl+st.h.FsLFEuhuAlE........lMDPKMDuGhlsst.p.......th-p.shcss....................csLs.tElluIhDplhsp.hsWhpGa.sLuQTlaTslYl..cp..............................................................sp.l.p.sL+....uashulh+hsshspphlspsthaE..E..E.DF.s.shshp..hhsphs...h....h...........................................................	0	77	120	182
+3271	PF04874	Mak16		Mak16 protein C-terminal region	Mifsud W	anon	Pfam-B_4960 (release 7.6)	Family	The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus [1].	20.30	20.30	20.30	21.30	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.49	0.72	-3.93	9	337	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	299	0	235	325	3	98.70	42	33.08	CHANGED	lspKlc+REppREcKALlAA+L-+sIE+ELl-RLKpGsYGD..aNhsppsacKhL-tcc.cppsEtE.-....p-Ep--uchEaVuDp..-..t...-lpDhED	.....................h.spKlcRREppREcKALsAA+lEpuIEKELLERL+p.Gs.YG...Dh..........h.....Nh.....spphacKsL........c..............p.......p.-...........................c............p............p...........s.........c......p.......-....t........-...............c..........t......-.......-........-....-.........E..c..-....................s..ch.....Ea..V..p.D...t-.ptp..-hp.D.hE.............................................................	1	82	130	195
+3272	PF01274	Malate_synthase		Malate synthase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	\N	20.00	20.00	20.00	20.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.84	0.70	-6.50	16	2722	2012-10-10 15:06:27	2003-04-07 12:59:11	17	11	2102	17	690	2600	3654	522.80	38	94.48	CHANGED	hslhsshs.ptscILTpcALsFlApL.pRcFsspp+pLLppRpchQtclDpGp.hs..........cFL.PETsalR.-ssWps.us.......................................................................................................................................lsssLtDR+VEITGPsD.RKMllNALNouAhsaMADFEDSsuP...........oWpNllpGQlNLpDAlcspIsapst.tsKpYpLs.......cphuhLhVRPRGWHLsE+Hlh.lDG.....-slsGu...lhDF...GLaFFHNt+ph.......lupGtGPYFYLPKMEuahEA+lWN-lFshApDhlGlPRGTI+ATVLIETlsAuapM-EIlYpLR-HuuGLNCGRWDYlFShIKshpsp.sshlLPDRstVTMssP....FMpAYschLlcTCH+RusaAhGGMAApIPI+cD.tANstAh-pV+tDKlREspsGaDGoWVAHPuLsslshpsFpphh.spPNQhphh+pc...plo....tsDLLs.thPsu.......phTpcGlcsNlplGlpYltAWL.pGlGC..VPlhp...LMEDAATAEISRsQlWQWl+HGVshc-....Gcplohphhtpll.cEphstlt.t.u....tsscap.Atphh.t.sh.uscasDFLTh.uYscls	.............................................................................................................h..hht..s..tptl.s.sphhphlspl.hpchsPcppp.L..LstRtphQtplDthp..hs...................sFL..pE..hs.lh..-.......ssh..hh..ts....................................................................................................................................................l....h-Lp.cp......s...ch..sG..s..s.-.t.........t.hlhs...s....l.sts.shshht.DhED....SlAs....................sW.slhp.Gplshp.....suhsGph....hp....s......s.s+.Yp.ht...............tshulLhlRshGaHhscpplh...hcG.........ptlsuu...lhDh......uLhh.h..Hshpsh.................u+..u.uusYhYlPK.........h........cu.pEAthWs-l......FshsE......chlGls..........p.GT.IKsslLlEpl.Ashphc......EllatlR-+lstlNs.GhhDhhhs..I+ohhpt.ss.hl...Rps...shhs.pP....alpAYpch....lpo..............................hh..huGhu.uh.h......ht..ps....................s...sphhs..chhtsKhtcspsGt......sssWVsp.PshAsh.ththapph......spssQhpl........tppp.....h.hs..........hcp.....LLs.....s..u...............pchp.ptlcsNlpshl.........tYl.tWl.pGs.GC..VP.hs...........LM.EDtAThcISppplhpWl+H.t...........h.s...hp..s...............h..........sohphht....phl.spp.t...................................spsta..p.h...........usph.s.lsh.uhp.l.................................................................................................................................	1	193	413	579
+3273	PF02330	MAM33		Mitochondrial glycoprotein	Mian N, Bateman A	anon	Pfam-B_17905 (release 5.2)	Domain	This mitochondrial matrix protein family contains members of the MAM33 family which bind to the globular 'heads' of C1Q.  It is thought to be involved in mitochondrial oxidative phosphorylation and in nucleus-mitochondrion interactions [1].	20.90	20.90	21.40	21.50	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.39	0.71	-4.56	7	515	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	299	14	330	513	1	177.80	22	68.50	CHANGED	LssEIc.E+c.th........pcsLs.hsh..shc.pssssEscLh+Ks.uuEcIpVsFNlspsls.sass-p-.spht...-pp.p.sssssh.s.ssppD.s.h.shsl-hphPtsp.lsacspA.....psDh..Fslc-h.htsou-s........EW..c...as.shcsLD.sLhD.thhcaLt-RGlDsshuc.LVphusshE+pEYIsaLEclKpFl	.........................................................................................................................................................Eh.......t.............................h...t............th.....p.sttth.Lh+ph.....tsEplpl.h...p.....hs...p..................................t...t.....t........t.......t...................................t..........................................................h...........h....s..l.sh..p..c.s..s..ps....lph.ps.sh............................ss........htIcpls..h.h.tp.sp..................t-h.......tt.h.....Yh...GPsassLD-pLpc.tlhcaLc.cRGlssphusal.cahphKEppEYlpWLc....slcpFl.................................................	0	97	176	265
+3274	PF02157	Man-6-P_recep		Mannose-6-phosphate receptor	Mian N, Bateman A	anon	IPR000296	Family	This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.	20.40	20.40	20.50	20.40	19.50	19.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.98	0.70	-5.39	2	195	2012-10-02 14:19:21	2003-04-07 12:59:11	10	3	147	24	129	261	1	170.90	29	61.70	CHANGED	M.PhpusWRTtLLLLLLhuVAVRESWQhEEKoCDLVGEKsKEScpElALLcRLpPLFNKSFESTVGQusDhYSYlFRVCREAuNHSSGAGLVQINKSNsKETVVGRhNETpIFNGSNWIMLIYKGGDEYDNHCG+EQRRAVVMISCNRHTLAsNFNPVSEERGKVQDCFYLFEMDSSLACSPElSHLSVGSILLVhhASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM	......................................................................................................................................................................................................................................................................................................................................................+p...t...h...h...Cs....p.p.......t........h...hs..p....p.p.ChY..hFEh.c......S........thAC.........s...s.......t..t....s.....p.....l..u.....s..G....u..l...h.h.llh.hhh.ls..VYl.l....GGhhYpRhVhtt+GhcQhPphuhW.tslhshh..t..D.hh.h..h......................................................................................	0	39	63	100
+3275	PF01232	Mannitol_dh	Mannitol_dh_N; 	Mannitol dehydrogenase Rossmann domain	Bateman A	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.86	0.71	-4.27	16	4952	2012-10-10 17:06:42	2003-04-07 12:59:11	18	14	2308	4	770	3058	403	147.30	28	33.49	CHANGED	.phlHhGsGNhtRu....alspLlsp.ssh-hshs-ls.pssst......LptQcphhslltp.......sscpsclluslssh.shpts..psllcthsc..sclVoholst.............sshPpIttslspst............Lp+RpstshsPhslluC-Nh	......................+hlHhGhGshtRua.s.ah..sc.L.Ls.......p.....s....s............h..............c..huhscV.s...hssst.........tL...p.t.Q....c...p.lh.s..h.lht..s.........tps...p...pscll...u.u..Vpt..s....l............s...s......t....p....-........t....t....ll....p.th.sp.stsclVohslTEtG.......ht...ttt..h.....s.s.t....P.h..Istsl.tps.......................................hlhth.lp.+R.p.....t.s.....s.h..p.s.hslluC-Nh..........................................	2	193	431	596
+3276	PF01050	MannoseP_isomer		Mannose-6-phosphate isomerase	Finn RD, Bateman A	anon	Pfam-B_899 (release 3.0)	Family	All of the members of this Pfam entry belong to family 2 of the mannose-6-phosphate isomerases. The type II phosphomannose isomerases are bifunctional  enzymes. This Pfam entry covers the isomerase domain.  The guanosine diphospho-D-mannose pyrophosphorylase domain is in another Pfam entry, see Pfam:PF00483.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.96	0.71	-4.60	17	2703	2012-10-10 13:59:34	2003-04-07 12:59:11	13	9	1834	0	687	2749	2876	136.20	49	31.58	CHANGED	lGlpsLVVVpTcDAlLVuc+ccsQDVKclVcpLKtpsRsE..tphHpcVaRPWGpYcsl-pGcRapVKRITVKPGp+LSlQhH+HRAEHWlVVuGTAcVThspcshlLsENESTYIPhGshHpLENPGKIPLELIEVQSGuYLGEDDIVRhED	..................................................lGlcDlllVpTtDAlLluc+spsQ-VKp........lVp.p.LKtp.s+..p.-......hp....H..pp..la.R..PWG.p.Yc...s.....l.....-.....t.....G.....p.....R.....ap...V..K.....R...I..s.....V.+PG.t.p..L..S.l.Q..h.Ha.H..R..u..E.H...W.l.V.V.s.GT.Ac..VT.h.....s.....s......c............h.l........l.s......c.....N-......S.........h.YIPh..G..shHp.L...cN........P...G.c...l..P.L...c...lI.E....V....Q.oGsY..LsEDDIVRhpD.............................................	0	212	432	567
+3277	PF05007	Mannosyl_trans		Mannosyltransferase (PIG-M)	Moxon SJ	anon	Pfam-B_5638 (release 7.6)	Family	PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilise nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates [1].	22.00	22.00	22.20	22.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.89	0.70	-4.74	6	328	2012-10-03 03:08:05	2003-04-07 12:59:11	8	8	285	0	238	382	29	248.70	35	61.37	CHANGED	ISTRGNu-ulluhlllhsLaLlpKpp.........hhtAullaG.hulHhKIYPllYslslhL.l.pshtcQ..........oshsphp....pLlsh..t.lhhl..lsoLhoFsusshhhYhhYG.pFL-csYLYHlhRcDhRHNFSsaahLLYLspAsphh..Sphl....tlhAFlPQhlLlhhh.uhpa......hcsLsashFlpTFsFVTaNKVCTSQYFlWYLshLPLlhsp..............h+h.SW++uLsllhLWhhsQuLWLhsAYhLEFpGhNsFh..laLuusLFFlsNsalLtQll	..........................................................................................ISTRGsu-ullssh.lhhhL..a.hl.h.ppc................................hhhAulhhG.luVHhKIYPlIYuhslhh.h.l...tp.p...t.tt.................................sh.hthhh.............ph.hsh..ptlh.hs......hsohh.oFhsls.h..hhYh.hY.G..hpFLpc.sY.LY.H.ls.Rh.DtRHNFSs.Y..h.hl.YL.s.....ss............pt...................u.......l..............................t.hhu...F..l....PQ..ll.L.h.h.h.....l...s.h.th.........................tccLs.h....shF.......h.....QT.hs...FVsF...NK..........VCTSQYFlWYlshLPlhlsp...................................p.h.......s..h.t...p....u..l...h.hl...h..lWhhu...QuhWLh.u.Yh........LEF.Gh.....s.......sF.h...lahuulhFhhsNshlLh.h.......................................................................................................	0	88	140	202
+3278	PF01575	MaoC_dehydratas	MaoC_like;	MaoC like domain	Bashton M, Bateman A	anon	Pfam-B_297 (release 4.0)	Family	The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1].  The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.33	0.71	-4.74	32	6997	2012-10-02 20:54:35	2003-04-07 12:59:11	14	82	2642	72	2491	6367	2455	119.40	20	29.77	CHANGED	phst.....hspshptphshslo...............sphthaAhhSGDhNPlHlDst.hAphutFs.ssIsHGhhohuhstthlhpthss........sthtthps+FhssVhsGsplpsphtpsu..hpttt.phhphpsshhsssss	...........................................ht..............t.hslo...................ppc..l.hhaA.......t..h..oGD.h..pP..lH...h...Dsp...hA.p....p.....s.....s.....F......s....p........h..I.s....H....G....h...h....o........h....u...h......h.......s...t..h...h...s..p..t.hs.s...............hsth....s....h...........p..l.+F..h...p..P.V.h..s....G.-.....s.l.p....s.p...h.plhs.....hp.tt...t..............st.t...................................................	0	656	1497	2090
+3279	PF03642	MAP		MAP domain	Bateman A	anon	Pfam-B_1396 (release 7.0)	Family	This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein) Swiss:Q9Z4J2 [1]. The protein has been found in a wide range of extracellular matrix proteins [1].	24.30	24.30	25.40	24.50	23.80	23.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.89	0.72	-3.76	10	1325	2012-10-01 21:38:54	2003-04-07 12:59:11	8	6	160	5	10	373	0	87.10	51	73.35	CHANGED	VPYTIuVNGsSssltScLsFsscpploYpDLssKVKSVLcsDRGIo-c-L+hAKpApYTVaFKNGsKKVVDLKScIaTtNLFsupDIK	.........VPYTIsVNGTSssIhSpLsFspspploYpDLssKVKSVLts-RGIo-hDL+hAKpApYTVaFKNGsKKVlcLKusha.TuNLlsssDIK.......	0	8	8	10
+3280	PF02991	Atg8	MAP1_LC3;	Autophagy protein Atg8 ubiquitin like	Griffiths-Jones SR	anon	Pfam-B_1384 (release 6.4)	Domain	Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity [1]. Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. The yeast proteins are involved in the autophagosome, and Atg8 binds Atg19, via its N-terminus and the C-terminus of Atg19.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.31	0.72	-4.05	9	1011	2012-10-03 10:59:06	2003-04-07 12:59:11	11	11	362	37	573	990	106	100.50	47	79.62	CHANGED	+RptEuc+IRpKYPDRIPVIlEKsspoc.lPslDK+KYLVPuDlTVGQFhalIRKRIpLsP-cAlFlFVss.olPsTushMuslYpcc+DEDGFLYhsYSuEsTFG	....................................................pRptEup+.IR....pKaP-Rl.......P.................VIlE.....+sp...............+..uc....ls.s..l.D...K.....+K.......a.L.V.....P....s..DlT....V...uQF....hal.I..RKRl.........p.............Ls.........s.............E.cAlF.l........F.V.........s..s.....s........l.P....s.........o.u..u........hMuplY-c.cK.D.E.DGFLYlsYSuEssFG......................	0	190	288	420
+3281	PF00414	MAP1B_neuraxin		Neuraxin and MAP1B repeat	Finn RD	anon	Prosite	Repeat	\N	20.60	20.60	22.30	20.60	18.00	20.50	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.94	0.73	-6.21	0.73	-4.33	11	173	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	24	0	75	166	0	16.90	54	3.54	CHANGED	TT+oP-susYsYEptEK	..TT+TP-sSuYSYEpoE+.	0	5	5	10
+3282	PF01124	MAPEG	FLAP;	MAPEG family	Finn RD, Bateman A, Brock T	anon	[1]	Family	This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme  catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.87	0.71	-4.53	319	2722	2009-01-15 18:05:59	2003-04-07 12:59:11	13	15	1609	34	1052	2147	1247	123.10	21	86.01	CHANGED	hh..hhs....slhshhhhhlshhssthRhttth.......................s.....................ts....hhpR.....................................stRAatNthEthshFhshhhlhtl.t......................shhsshhuhhalsuRllas.hsa...hts......hsh..hRs.hs....ahluhlshhslhlhslh	.........................................................................................................................h.hhhsslhslhh.hhhsh.ls.p.h.R.h.p.hp..s..h.......st.............s.................................hs.....thpp...............................shR..sa.tNsh.EhhPlal..s.h.h.lh.hth..s......ss..............s.......shhsth..hu.......hlalsuRlhah.hua..........hts.......hhh.......hRt..hs....hh..hshhshlhhhlhsh.h.............................................................................	0	315	546	790
+3283	PF01914	MarC	UPF0056; 	MarC family integral membrane protein	Enright A, Ouzounis C, Bateman A, Dlakic M	anon	Enright A	Family	Integral membrane protein family that includes the antibiotic resistance protein MarC.  These proteins may be transporters.	23.60	23.60	23.70	23.80	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.15	0.71	-5.20	12	4024	2012-10-03 02:02:08	2003-04-07 12:59:11	12	4	2220	0	892	2286	718	199.30	30	95.29	CHANGED	hphhhtshlsLhhlhsPlGslPlFloLhpphstcc+pplhh+sslhuhllLhlFhhhGchIhp.hFGIslsuh+lAGGIlLFhIuhcMlpup.pt.....ptpppEtpt...h-plullPLAhPLlAGPGuIToshlhhsptss.........hhhshlulhLshhhshlhhh.ushlhRhlGctGlsslsRlhGllLsslulQhllsGlpshh	............................hhpshlsLhslhsPlG..slPl.Fluls.p.ths.s....tpR....p....c......h.....s.....hp.....uslhsh..lll.h.l.hhahGphlLp.hFGIolsuh+I.AGGlllhhIA.h.c..Ml.h.s.ptst.................t..p.s..p..p.....p....t......t..................t......................t....ps..l....ulVPLAhP..lhAGPGs.I.uslllh...u.s.p.h.t.s..........h...t..h..h.s..h....h.....l.u.lh.l.s.h.l....hs.a.h...l...h.t.h.us.hlhRl....L..Gp...s....G.......l....sllsRlMGllLsslulphllsGlpth......................	0	241	508	711
+3284	PF02063	MARCKS		MARCKS family	Mian N, Bateman A	anon	IPR002101	Family	\N	19.50	19.50	21.30	20.30	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.43	0.70	-4.56	4	119	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	35	1	60	106	0	175.90	36	96.19	CHANGED	GAQFSKTAAKGEAA.AE+PGE.AVAuSPSKANGQENGHVKVNGDASPAAAEuG.KEElQANGSAPA...EEsuKEEAAou...............tAAsccEAuAu...........sAEuEsAEPuSP...AEGEuA.....opTp..cAtssATPSsSsETPKKKKKRFSFKKSFKLSGFSFKKNKKEuGEGAEuE.GAsAt..tEtAK--AAAAAsEAsst..EpAtAsuEEAuAAus.pttttcEs..AusupPp..EsKs-EA..APEK.PsuEEspsAEE...pKsEEKsAEEAs...AsuAA...sEAPuu.......EpEAAsAEEP.........AAs..sQEAsSEsSPt..AssAE	............................ss+t-ss.s-...t..s..ss..sKsNGQ....ENGH.s+.NGshost.........................................................................spu-.sh-sss..........................u...ts.s...sspETPKKKK.+FSFKK.sFKLSGhSFK+s+KEsutsupst..uss.t...t-ttttt.t......ts.t......t....-ttt.ss..ps....t...........t.t...tttst..t..E..t..stts...t..pt...st...t.....................................................................................................................................	0	3	11	27
+3285	PF02124	Marek_A		Marek's disease glycoprotein A	Mian N, Bateman A	anon	IPR001654	Family	\N	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.45	0.70	-4.86	15	236	2012-10-03 02:52:13	2003-04-07 12:59:11	10	1	52	0	0	276	0	201.10	41	44.49	CHANGED	YYPspSsclpWFpsGp.sVc.spalcsshphts-.G.lhopsSslol.........ssssstsh.PPolRCp......lsWa+cuVuppRh.......suussPsVYhtPplol.cFtsGcAVCsApCVPcs..VplpWhlsDt....sssssshtsGsCsp+PGLVNlRSshslSttcushcYTCpLsGYPpslPsFpcotsaDASPpssutshllsll...uVlsGlsslullsllsslClhp	........................................................YYP..psVchpWFpcst.tVt.ssplcsthptpss...G..FopVSsVT..........t..ssssps..PsslpCp......hsWaRD..uVs.pRh.......sAsuhPtVhs.hPslol.....tF....t.s.uasVCTAtCVPcG..VshsWhlsDss....sAspsshpsG.Csc+PGLsslRSshPl..S..t.....t..u...-YoC..+L..s..GYPsslPs..h......ptptoa..p.s..s..Ptsso...V.hphl...ulhhhlhshGllslhshlhlh.......................................................	0	0	0	0
+3286	PF01047	MarR		MarR family	Finn RD, Bateman A	anon	Pfam-B_269 (release 3.0)	Family	The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR.  A large number of compounds induce transcription of the mar operon.  This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.37	0.72	-4.26	38	19890	2012-10-04 14:01:12	2003-04-07 12:59:11	17	44	3773	111	4329	25839	3062	58.30	23	35.57	CHANGED	lohspatlLthltppss.hshs....cLApphplspuslTphlc+LEcpGhlpRppsspD+Rpl	.................................lo.sph.h.l...L...h....h....l......t.....p.....p.........s........s.....h.....s.hp............cL....uc.tl..t.....l....sp........u.o.lo..p...hlccL..Ec..c..G..hl..pR.p.p..s.....p..D+Rt..........................	0	1317	2694	3560
+3287	PF02064	MAS20		MAS20 protein import receptor	Mian N, Bateman A	anon	IPR002056	Family	\N	23.40	23.40	23.60	30.10	23.10	22.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.45	0.71	-4.20	33	336	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	234	22	220	310	0	124.60	35	71.87	CHANGED	lsAGl.u..ushFlGYClYFD+KRRSDP-aK+KL+ERR...+cptpp..........ttsssstl.P-h.pD....pcslpcaFLp..ElphGEpLlspGch-pGlcHLs.NAlhVCuQPs....pLLplLQpoLPsplFphLlp+Ltt	....................................................sus.s.ush.hlGYs.lYFDhKRRsDPpF++.pL..+..c..+R....+ppttt...................................t.ttthttlssh...p-..................s-thppaFhpplphGE............pL...hu...p...G..c........h.....p..........c....ust.+.hhpAl.tVhsQPp....pLLplhppTlP.sVaphLlp.h..h.........................	0	56	93	163
+3288	PF04769	MAT_Alpha1		Mating-type protein MAT alpha 1	Kerrison ND	anon	DOMO:DM04990;	Family	This family includes Saccharomyces cerevisiae mating type protein alpha 1 (Swiss:P01365).  Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes.\	    MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes [1].\	Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (Pfam:PF04648) response pathway [1].	22.10	22.10	22.10	22.80	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.22	0.71	-4.99	13	507	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	358	0	51	428	0	156.70	31	59.93	CHANGED	chlss.....hhpshtphccsAuhtAhouphhhss.......hst.ssssppAKKslNuFhuFRoYYh..shFsphPQKchSshlolLWptDPp+shWslMspsaSsIRDpluK......ppssLspFlshtsPhhtl.s.stYhplhGWsLopsppGshslp+sssschpphspshs.shsLshpslhshlp.hhhsssashhsphsssoaphhphss	............................................................................................tth..t.t.s.p.t.s.+.+.sLNuFhuFRsY................Yh..hhFs.s.hp.QKphSshlshLWps.D.Ph.+.scWulhAKsYShlRDphsc......tpssLstFhslhsP..hhsh..st.Ylt.hGWt.....h....t.s.pu...................h.p..h....t...............h...slht.h....h..........................................................................................	0	8	25	44
+3289	PF01554	MatE	UPF0013; 	MatE	Bateman A	anon	Pfam-B_163 (release 4.0)	Family	The MatE domain	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.61	0.71	-4.62	58	32381	2012-10-02 21:24:20	2003-04-07 12:59:11	13	52	4365	8	7913	28954	6802	160.40	16	68.74	CHANGED	Phhls.hlps..........hhthlsshhlupl..GstslAuhuluhslhshhhh.........hshGlusuhsslsupthGApphcphthshtpuhhlshhlulhhsllhhhhsp.lhphhssstp......lhphutpalhhhhhshshh.sh.hshsuhLputGcschshhlshhuh.llslslsal	...................................................................Phhlt.hh...........................hh.th.l.s......s..h.h....l....u.........p......h.......G...........s.......t..s............l........A.....u......h.....u....l..........s.....h..s..l.h.t.h.h.hh.........................hh.h.u.l.u.....hu..s.....s........s........l.........l....u......p.........t..........h.......G...........u........p........c............h............c............p........s................p......p......h........h....t...t....u....h..............h....h.u..hh.h.u.l.l.h.....sl.l...h....h...h..h.s.....p.....l....l..t....l....h.....s....s.....s..s.p............................l.h.p......h..u......t...p.a....l..h.....l.h....h....h......s....h............h....h.h.....s....h....t...h......s.....h.....s.............u.................h...hp...u.h....u...p....s...p......h...s...hh.hsh...h...s..h.....llsl.shs..........................................................	0	2610	5153	6676
+3290	PF01824	MatK_N		MatK/TrnK amino terminal region	Bateman A	anon	Pfam-B_30 (release 4.2)	Family	The function of this region is unknown.	21.70	21.70	21.70	21.70	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.12	0.70	-5.34	15	38881	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	26823	0	17	37918	0	249.20	57	67.98	CHANGED	MEEappYLELD+SQQHsFLYPLIFQEYIYALAHD+GLNR.....SILLENsGYDN.K.ShLIVKRLIT....RMYQQNHhllSsNDSNQNhFh....GaNKNhYS..Q..MISEGFAlIVEIPFSLRLlSSL...Et.KclVKSaN..LRSIHSIFPFLEDpFuHLNYVLDILIPaPIHLEILVQTLRYWVKDASSLHLLRFFLaEYpNWNoLIT..sKKu.asF.SKRNpR..hFLFLYNSaVCEYESIFlFLRNQSSHLRSsSSGshLERIaFYGKIE+hl.EVFs+DFpssLWLFKDPFhHYVRYQGKSILASKGTsLLMNKWKYYLVNFWQCaFYlWsQPGRIaINQLSNHSLDFLG	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.......p....l.....clhIPaP.lH.hEIL..VQhLp..hWl.pDssSL..HLL.....R.....F.F.L..a...E..........Y...p.....N.........a......N......S......L...I...T................sK....K.........u.........h.................h..........F.....S........K....c.............N....p..R.........h.F........h....F....L....Y....N.....S.aV.h.EY..ESl.F.l.F.L.R.p...Q.S.S..a.L...R...S.TS...G....s..h.L..ER.la..FY..s.....K.....I.........E.......+.......l............l................V.....a........s......p........s........F........p.......t....h...L......W..h.......F.....K..D..P..F......h...H.YV...R...Y..Q.GK.u.ILA..S..K..G.......T..........L...L...M..p.K..WKaYLVNhWQ.ha..Fhh..W..s.Q..P.....t...R..I..a..I...N..Q..L...S..p..a...S...hpFLG............................................................................	0	2	8	14
+3291	PF00661	Matrix		Viral matrix protein	Bateman A	anon	Pfam-B_128 (release 2.1)	Family	Found in Morbillivirus and paramyxovirus, pneumovirus.	19.80	19.80	25.80	23.60	17.30	15.60	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-11.86	0.70	-6.13	13	784	2009-01-15 18:05:59	2003-04-07 12:59:11	16	3	105	0	0	688	0	266.80	48	96.27	CHANGED	pshhshspsuhsssusLpPhPlphss....cG+Ll.QlRltclspssc+cpshsal.sYGFlcsscppsshlGt.p...ps.ttthhTuuhLPLGsG.shusspclLcthsphcIpVR+TAuspEplVFplsshsplLpsaphshpphhlhsAsKhs+uPsplssshshpaplsFlSlThhsssttaplP+slLchRSppshulpLpVhl+lpscs-SshhKshhsccptcs..AohhlHlsNlp+pcsc..hYss-YhppKlcpMpLshuLuslhGsoltl+usG+lsKThtshhuh+thsCaPLhDlsPsLs+hLWusuCEIsclpAILQsSs.p-hhhasDlIhcclphhhc	..............o..hhth..ss...pspl.sh....h..h.t......ctplh.QhRl.c.s.hscpc-s.hahhhhGhl.p.ss...tsslG...............hs.u.LsLGss.ssuc..-Lh+tshphslss++oAs.sEchVF..sps.plLpshhhshsphs.hsAsphspAsphlPhsss.ca+VsahSlThlscpshYplPp.thLchpusshhslsLpVTlcl-scscSshlKolsc...u-sshh....AslalHIG.hspscp+h+phohDhhcpKIR+hsLsVuLuDVhGsSlhl+upGthoKhLts.hu.ptshCYPlhshs.pls+lLWpppsplhplpsllQsus.pthtlhsDh.lsssph.h.t.............	0	0	0	0
+3292	PF03819	MazG		MazG nucleotide pyrophosphohydrolase domain	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Domain	This domain is about 100 amino acid residues in length. It is found in the MazG protein from E. coli. It contains four conserved negatively charged residues that probably form an active site or metal binding site. This domain is found in isolation in some proteins as well as associated with Pfam:PF00590. This domain is clearly related to Pfam:PF01503 another pyrophosphohydrolase involved in histidine biosynthesis. This family may be structurally related to the NUDIX domain Pfam:PF00293 (Bateman A pers. obs.).	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.32	0.72	-4.03	54	7328	2012-10-01 21:36:44	2003-04-07 12:59:11	12	20	3581	41	1765	5952	4148	73.70	28	47.30	CHANGED	Qohpolh.allEEshEls-AI.cc..........p-.s...........plc-ELGDlLhpVlhhuplupc..pstFslp-VhpplscKhhcR+P+lF	..........................................................shh.hlhEEstE.l.h.-...s..l....pp.........................................p.-.tp..................................cl.p.-ELG....DlLhtl..l.hhAph...............hthc.hccs..hpph...scKh.cRh..............................	1	620	1185	1510
+3293	PF04837	MbeB_N		MbeB-like, N-term conserved region	Mifsud W	anon	Pfam-B_3854 (release 7.6)	Family	This family represents an N-terminal conserved region of MbeB/MobB proteins. These proteins are essential for specific plasmid transfer.	21.30	21.30	21.70	21.70	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.31	0.72	-3.87	9	115	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	74	0	3	93	2	51.20	41	30.92	CHANGED	MSplLsLApsFEp+SKppupSTpchlpssFccHEpslpptLppupp+Is-AI	.....MSplLsLAp-F...EpKSKpctpSTpphLpssFpchEpulpptLppupp+IpsAI.....	0	1	1	1
+3294	PF04899	MbeD_MobD		MbeD/MobD like 	Finn RD	anon	Pfam-B_5673 (release 7.6)	Family	The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilisation and transfer in the presence of conjugative plasmids [1].	21.40	21.40	21.40	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.37	0.72	-4.07	6	132	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	105	0	14	86	0	74.90	43	78.49	CHANGED	MTELEppLLSALEQLQQDYpQRLpEWESAFs-hQ+MhuLppRENA.......ALSEpVTsLSQQVpcLScQlcRLSp	............................MpELEhpLLsAhppLQpsappphppWpSuaspLQphhphoppcpu.......sLpt+sptLspplppLstphp...................................................	0	5	8	10
+3295	PF03621	MbtH		MbtH-like protein	Yeats C, Eberhardt R	anon	Yeats C	Domain	This domain is found in the MbtH protein Swiss:O05821 as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologues were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al [1]. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues [2].  The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape [3]. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids [3-6].	20.80	20.80	21.10	21.10	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.81	0.72	-4.60	87	1247	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	966	4	274	742	10	53.60	46	64.74	CHANGED	M....sssF-csss....pahVLlNcEtQaSLWPshtslPsGWpssh...G.su.......sRpsCLcal-p	...............M..oNPFDcspG.....sFhVLhNs-tQaSLWPsh..sslPAGWclVht.st.......o+tuClpalE........	0	50	144	224
+3296	PF02289	MCH		Cyclohydrolase (MCH)	Mian N, Bateman A	anon	Pfam-B_6511 (release 5.2)	Domain	Methenyl tetrahydromethanopterin cyclohydrolase EC:3.5.4.27 is involved in methanogenesis in bacteria and archaea, producing methane from  carbon monoxide or carbon dioxide.	25.00	25.00	102.30	102.20	23.50	22.50	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.00	0.70	-5.39	6	211	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	188	1	101	219	69	285.00	43	96.87	CHANGED	SVNchAtplVEcMl-tuE-L+l-VtKLENGATVlDCGVNssGSa-AGhhaoclCLGGLAcV..slsshphsulshPsVplpTDaPAIAsLGuQKAGWplp..VGc..YFAMGSGPARALALKPKETYEEIGYEDDADlAVLsLEuscLPsEcVsEalAcECuV-PENVYlLVAPTASlVGSlQISuRVVEsGlaKhhEVh.FDls+lK.usGhAPIAPlhsDDlpAMGpTNDsllYGGpsahaVcuD-..s-lcplscplPSssScDYGKPFh-lFKcAsYDFYKIDsGhFAPAcllVNDLpTGKoapuGclNsElLhpSFG	.........................SlNthuh.ll.cphlp.u....ccLpltltphpsGspllDsGlp.s.GuhcAGhhhsclChGGLupV...sht....t..th...t.sh.h.shlpVpospPslACLuSQhAGWpls....htc.....aFAlGSGPARALAtc.........c........cla.c-l.s..Yc...D.pu-.t..u....lL.sLEusplPsppVs-clAcpCGV.sPpslhlllAPTsSlAGoVQlsuRVlEsAlHKhppLt.F-lpcIlsuhGsAPluPst..sDtlpAMGRTNDAllYGGpshhhVc..ssp..tthpplspplPSss.Sc-YG+PFh-lFcphshDFYclDstl.FuPApVhlsslpoGcsapsGpls.plLtpSF.............	0	27	71	90
+3297	PF00493	MCM		MCM2/3/5 family	Bateman A, Finn RD	anon	Prosite	Family	\N	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-12.00	0.70	-5.64	62	3858	2012-10-05 12:31:08	2003-04-07 12:59:11	18	63	938	2	2067	6744	833	253.70	39	40.85	CHANGED	-hcplpcl.uccs..slhpplspSlAPsIaG..p--.lK+AlhLtLhGGsp.K..phsc.thc..lRGDINlLllGDPG.sAKSQlLKal.p.pluPRuVYToG+GSSAsGL.TAuVh+Dstot-...asLEuGALVLADpGlCCIDEFDKMs-pDRsulHEAMEQQTISIuKAG.Ihso.LNARsSlLAAANPh..hGRYstp+ohspNlslssslLSRFDLl.FllhD.ps-cppDpplAc+llshHhtt...........................ppphptp.................................lshchL++YItYA.R.phpP..t....Loppu.pctlsphYlphRp.s........tt...ttthslTsRQLESlIRLoEAhA+h+LuphVstcDVccAl+LhppShh	.........................................................................................................pplpph..t..p.p.....plach..lspSlAPp.Ia..........G..........p..............pc...l.......K+Al.lLhL.......h.G........Gs.........p.............K...................p..h.....s.....s...........s..h..+.................lR...GD......I.....Nlh.lhG...DPusuK....S...Q.h..........L.p....a....h..............p....h....s.......s...........h..........u........l..........h...........o....o...........G.....p............u...u..........S.......u...s............G.......L........T......A............t..........l.....h.....+........D.........................o..t..p......................hh....l.......E..u.......G.A........h.......V............L.u..D.t....G.....l.............sh....IDEF.D.K..Mp.t.....s...psslHE.......sMEQ..Q..o.l.......ol........u.....K....AG......l..h.sp..L..p..uR.s.ul...lA..Au...N.Ph..............u.................p....a..................s................................h.........s................................t.........N.........l............t............h.........sl..lS.R....F..D..l..............h.........h........l........l.........h........D.............s...............................D....................l....up.....a..l.ht..a..t...................................................................................................................................................................................h.s...t..............h....p...p..Y....l.......h.s...+..................t....h..t............P.......h.....................l..s.........s....t..p......h.l......p....Y....t.hRp.t..................................t.......tt......h..os.RpLts....hlRlup....uhA+hphp...t................s.t.t.cst..Ahplh.....h...........................................................................................................................................................	0	763	1189	1734
+3298	PF00015	MCPsignal		Methyl-accepting chemotaxis protein (MCP) signalling domain	Sonnhammer ELL	anon	Blast MCP1_ECOLI/361-421	Family	This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.51	0.70	-4.79	9	30898	2011-09-19 18:58:56	2003-04-07 12:59:11	16	309	2287	12	9245	27179	1335	198.30	30	36.30	CHANGED	ppAo-hAppAsppA..............ppsspsVcpslpshcplsspSppIscIlsVIspIA.QTNlLALNAAlEAARAG..EpGRGFAVVAsEVRsLAp+SApAA+EIcsLIppsspp..............l-sGsshlcpTucshpcIVsulsclsshls-IAuuosEQSpulppls....pulschsplTpps..............sAhsEEuuAAutsLcppApcLpphlstF+lp	.......................................................................ttt.........................s..............................h...p...p....h....s...p.......t....h.......p....p.......s.......s....p.......s...h.......p....p.......l....s...p....p....u.......p.......p.......I.s...........p...l...l.......s.l.......I...ps.......I...A...p...QTNL......LALNA.A.I....E.A.....A..R...A....G............Ep....G......R..G.........F.AVVAsE.......V.......RpLAp+.....o.......t.......p.......u.......s.......p.......E.......I.......p...........p.......h..........I....p.......p.......h..............p.......p.......p.............................t.....................................................................................h...............t...........................................................................s........p..........p........u.......s...............p........h..................s..............p.......p.......s.......s...........p.............s..............h..............p..................p..............I..............s..................p..............s.......l..............p....p..............l.......s.......s...........h..............h..............p..............p..............I.......u..............s..............u...........s..............p.......c......Q.......s.......p........s.......h....p....p.....ls................ps...l....s.......p....l...s....p....h...s.pp.s..........................................ss.h....spp.s...s.......t....s.......u.......p.......p.......L.......p.p.....u.......ppL.pphlt.Fp..................................................................................................................	0	2775	5451	7351
+3299	PF02993	MCPVI		Minor capsid protein VI	Griffiths-Jones SR	anon	Pfam-B_1634 (release 6.4)	Family	This minor capsid protein may act as a link between the external capsid and the internal DNA-protein core.\	    The C-terminal 11 residues may function as a protease cofactor leading to enzyme activation [1].	25.00	25.00	27.70	27.70	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.55	0.70	-4.21	9	139	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	101	1	0	157	0	227.40	52	97.63	CHANGED	FusLAPRpGspPhhu..psIGsS-h+GGtFsWGSLhS....Gl+shGSslpNhup+hhNSpThp.l+ptlpDoslhcpVsphhupulsulVDIuR.clppclpphh-+h.s.....-p.hsptcsh..s...h.tstpstscP.scpshlstsstP.Psh.psl..hs......hsspcPhhs.shssss...psPsplshPP..tsp....ssss...s.....ssppsp..............+.hRsusWQusLssllGhGVpsspRRpCY	...........FuSLAPRHGoRPaMGTWs-IGTSQLNGGAFNWuSlWS....GLKNFGSTl+oYGsKAWNSSTGQhLR-KLKDQNFQQKVVDGlASGINGVVDlANQAVQ+pIsSRLD..P..hPs..................pt.h...-th.................s+G-KRPRP....DtEEsh.lhpscEP.PSYEEAlK.G............hPsTRP.IAshAs.uVh.......pPsTLDLPP....sPs....sssss........ss.s.s.....s....ss.ssstR..................ssttpt.stNWQSTLsSIVGLGVpSlKRRRCY.................	0	0	0	0
+3300	PF02249	MCR_alpha		Methyl-coenzyme M reductase alpha subunit, C-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2706 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain is comprised of an all-alpha multi-helical bundle.	25.00	25.00	32.70	26.70	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.78	0.71	-4.12	22	7244	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	318	31	49	7541	13	118.60	61	67.10	CHANGED	DQIWLGSYMSGGVGFTQYATAAYTDNILDDasYY....GhDYlp-KYG...s........scu.s.oh-sVpDlATEVTLYuLEQYEcYPThLEDHFGGSQRAsVhAAAuGsosAhATGNupAGLuuWYLS.hLHKEuaGRL	....................................GVGF.TQYATAAY..TDNI.LDDas.YY....GhD.YlcDKYG.......s........h.s..+sKs..ThDlVpDl.ATEVTlYGhE...QYEpaPThLEsHFGG....SQRAuVlAAAuG.hosulATGNuNAGL..suWYLS.MhLHKEuauRL..............................................................................	0	10	32	41
+3301	PF02745	MCR_alpha_N		Methyl-coenzyme M reductase alpha subunit, N-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2706 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has a ferredoxin-like fold.	20.50	20.50	21.00	20.50	19.40	20.00	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.81	0.70	-5.19	5	1424	2009-09-10 16:32:42	2003-04-07 12:59:11	10	3	189	31	50	1557	13	56.70	70	20.77	CHANGED	EKKLFl-AL+cKFc.E-PcEKpTKFYsFGGWKQSERK+EFVEaAKKlAEKRG.IPFYNPDI..GVPLGQRKLMPYpVSGTDsaVEGDDLHFVNNAAMQQMWDDIRRTVIVGMDTAHcVLEKRLGKEVTPETINEYMETlNHALPGGAVVQEHMVElHPGLVsDCYAKIFTGDDELADEIDK+FLIDINKpFPEEQAEQLKKAIG+RTYQVsRlPTIVuRsCDGATsSRWSAMQIGMSFISAYKlCAGEAAlADFSFAAKHA-VIpMGohLP	.....................................................................................................................................................................................................................................................................AMQIGMSFIuAY+MCA.GEAAVADLAaAAKHAuVlpMushLP............	1	11	33	42
+3302	PF02241	MCR_beta		Methyl-coenzyme M reductase beta subunit, C-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2692 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain of MCR beta has an all-alpha fold with buried central helix.	25.00	25.00	325.40	325.00	24.30	18.90	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.52	0.70	-5.17	6	82	2009-11-23 11:17:05	2003-04-07 12:59:11	13	1	65	31	49	86	12	252.00	65	57.60	CHANGED	GYALRNIMsNHlVAsT+KNThNAlALuoILEQTAMFEMGDAVGuFERhHLLGLAYQGLNADNLVaDLVKtNGKcGTVGTVVASlVERALEDGVI+VcKpLsSGFKlYcPsDhAhWNAYAAAGLVAAshVNsGAARAAQGVASTlLYYNDILEYETGLPGVDFGRAEGTAVGFSFFSHSIYGGGGPGIFpGNHlVTRHSKGFAIPsVAAAMCLDAGTQMFSPE+TSuLlGoVaStIDEFREPLKYVsEGAsElKc+	GYuLRNIhsNHhVAhT+KNshpAsALoSIhEQsAhFEMGsAlGsFERhHLLGLAYQGLNANNlVaDLVKpNGcsGTVGoVVtSlVERAlEDGVIpscKphsSG.aphYcssDsshWNAYAAAGhlAAshVNCGAuRAAQuVuSTlLYaNDlLEaETGLPGlDaGRspGTAVGFSFFSHSIYGGGGPGlFNGNHVVTRHSKGFAIPCVsAAMsLDAGTQMFSPEpTSuLlGsVautI-EFREPlKhVAcuA.........	0	10	32	41
+3303	PF02783	MCR_beta_N		Methyl-coenzyme M reductase beta subunit, N-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2692 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has an alpha/beta ferredoxin-like fold.	20.90	20.90	23.90	32.00	20.00	17.60	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.92	0.71	-4.83	7	83	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	66	31	49	89	12	178.50	51	41.17	CHANGED	DplDLYD-+GpLlEEsVPLEAlSPL+NPsIpslVpDlKRoVAVNLAGIEsALpsuplGGKushI.GREl-LsIVtNAEuIA-plK+hlQVsEDDDTsVcLlssGKphLlQlPSpRlcVAA-YosusLlsutAlspAIIctF-VDMaDAshVKuAVhGpYPQolDahGuNlAolLusP.pLEG	...D+IDLYDD+GpLLcpsVPLEAISPLpNsuIp+llpssKRTVAVNLAGIEsuL+TGplGGKuppI.GRELDlsIVsNA-uIA-clcchlpVp-sDDTsVcllsGGKphLVQlPotRlcsAA-YoluhhssAuAlspAII-pFclsMaDAshV+AAVhGpYPQohDhtGGNluolLslPpp.EG.........	0	10	32	41
+3304	PF02505	MCR_D		Methyl-coenzyme M reductase operon protein D	Mian N, Bateman A	anon	Pfam-B_2115 (release 5.4)	Family	Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha  (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240) [1]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D [2]. The function of proteins C and D (this  family) is unknown.	25.00	25.00	108.30	108.10	18.90	17.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.76	0.71	-4.65	10	75	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	59	0	51	72	4	148.00	41	92.72	CHANGED	I-VcIFPHRlLpA-TTEKlLNclY-.l-GltRVllHGpsLPcpVsaGPA+GhPVNHs-R+lIpVKGp-lEL+VpVGRIhVplcD.c..-ppl-cI-EICcElhPFuYclpsG+Fh+ccPTVTDYlKYGcc....lcclDsRLlGhVDPpuRhpssVslIK	..h-lEIFPpRhLps-TTEKlLNclhs.l.cGlpRlllaG.sLPcpVsYGPA+GtPlsHs-R+hIpVpGpslELpVpVGRlhlpl-s.....-shl-cIcclCc-.hh...P...FuYclp.....GpFh+scsTVoDYhKYG.p.....sphDccllGhsDP+u+hppplthl..........	0	11	32	42
+3305	PF02240	MCR_gamma		Methyl-coenzyme M reductase gamma subunit	Mian N, Bateman A	anon	Pfam-B_2713 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family)  subunits with two identical nickel porphinoid active sites [1].	25.00	25.00	320.70	320.50	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.56	0.70	-5.24	7	85	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	67	31	49	88	13	246.80	61	94.67	CHANGED	sQaY.PGpTplApNRRKaMNP-hELcKLREIsDEDlV+lLGHRsPGE-Y.SVHPPLEEMD.PEDslR-hVEPhpGAKtGcRVRYIQFsDSMY.APAQPY.RuRsYhWRaRGlDsGTLSGRQlIEhREpDLEpluK..LlETEhFDPApsGlRGATVHGHSLRLDENGlMFDhLpRhlasE-TG+VhhVKDQVGc.LDEPVDlGcPLsE-pLtchTTIYRlDslshR-DcEhlElVpRIHphRThuGFtP	...PQaYPGsTpVApNRRKaMNPshcLEKLR-IsDEDlV+lLGHRuPGE-YpolHPPL-EM-EP-sslR-lVEPhsGAKAGDRlRYIQFsDSMY.APuQPY.RuhshhhRaRGlDsGTLSGRQlIEsRERDLEcloK..Ll-TEhFDPApsGlRGATVHGHSLRLDEsGhMFDhLpRhlhsccoGpVhYVKDQVGpPLDc.VslGcPlsE-cL+c+TTIYR.hDsluh........R-DtEsl-lVp+IHptRThuGFt....	0	10	32	41
+3306	PF02315	MDH		Methanol dehydrogenase beta subunit	Mian N, Bateman A	anon	Pfam-B_12628 (release 5.2)	Domain	Methanol dehydrogenase (MDH) is a bacterial periplasmic quinoprotein that oxidises methanol to formaldehyde. MDH is a tetramer of two alpha and two beta subunits. This family contains the small beta subunit.	20.60	20.60	21.10	20.70	19.70	16.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.06	0.72	-4.05	4	44	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	44	23	21	47	0	90.00	58	93.97	CHANGED	MKplLshhslAushu..hsssALAYDGTpCKAPGNCWEPKPGaPEKIAGSKYDPKHDPtELsKQsESlKsM-ARNtpRltNhKKTGKF.YDVKKI	..............hhhhshhsushs...hussAhAYDGTpCKAPGsCWEPKPGa...P-KlAGSKYDPKHDPpELsKQs.pSIcuMEpRNtKRltpFKKTG+FhYDVpc........	0	6	16	18
+3308	PF04349	MdoG		Periplasmic glucan biosynthesis protein, MdoG	Mifsud W	anon	COG3131	Family	This family represents MdoG, a protein that is necessary for the synthesis of periplasmic glucans. The function of MdoG remains unknown. It has been suggested that it may catalyse the addition of branches to a linear glucan backbone.	25.00	25.00	28.80	28.60	17.70	17.30	hmmbuild  -o /dev/null HMM SEED	484	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.60	0.70	-6.23	4	1625	2012-10-02 23:57:29	2003-04-07 12:59:11	7	2	926	2	268	967	64	475.30	48	91.60	CHANGED	FshDsVscpA+sLAucsYpu.KssLPoshpchpas-YQpIRFppD+AhWss.csPFplpFaHpGhaFcoPV+IsEVsustspclpYDPshFsaG.slhpscpssKDLGaAGFRVhYPlNotccpD.ElssFLGASYFRslGpGpsYGLSARGLAIcTA.PuGEEFPcF+tFWlE+PpssscplVlYALLDSPpsoGAYRFslpPGcsslMDVputla.R-cluKLGlAPhTSMahaGsNp.p.spsaRPElHDSsGL.lhsGNGEWlWRPLsNPpaLpVSsF.spNPpGFGLLQRsRDFu+YpDL-s+Y-hRPShWVEPKGsWGcGoVpLVEIPT.DETpDNIVAFWsPcp.PcsGpEhpFuY+LpWu.spsclp.PpsuaVppTtpuhGDVtppshhR...hohtFVVDFpGsthKtLssstPVospsslcsNutllEs.olR.NPsh+GaRLshclcst-s.pp.sEhRAtLsspsscPLoETW.YQhs...h	..................................Fshs.ltphApsLAtpsap..u.s..p.s.LPs.s.lt..shsassY.ppIQass-+uhWps....l.c.p...aclpFaH..G.MhFcp.V+l.pV..s........s.......s....t....s+c.......I+.......asP-hFsa.s.......-s...t..h....D..p...-..s...s...p.....D..L...G...FAGFRVh..h.....s.......h...s..p........p.......t..pc....-lVSFLGASYFRslGsst.YGLSARGLAIDT.uh.s.o.s..EEFPcFptFWlEpP......K....P.s.s.pplTlYALLDSPssTGAY+Fs...I..p..s..G.+.s....s.l.h.DVpu+lYhR............cc............lpcLGlAPhTSMFhaGsN......p.......p................ss...saRPplHDS-GLuha.s.G....N....G.........E.........WIWRPLNNP....p.+.L.p.houa.ssc.N.P+GFGLLQRsRDFS+YpDltshY-pRPShWVE.P...........+....u.........c...........W.GKGsVpLlEIPTssET.DNIVAaWpP-p.hs..csG.......cEhsFpY+LhWS...s...............p.s.......l+..ss.h....AhVht.....T......RpuhG...s.h...........p......ss........hh.....chshtFsVDFsGu.-h.K..........h.sts.s.......P.h.....sh.pss.I.s.s.s.u..thl...........cp............p.lt..Y....s..s..s..h..c..G.aRlhhchh.......s.p..........ss....pc..........ss-MRhhLts...t.s....ps..lSETW.YQh..h...................................................................	0	60	133	191
+3309	PF02975	Me-amine-dh_L	Me-amine-deh_L; 	Methylamine dehydrogenase, L chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	25.50	25.40	17.80	16.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-11.05	0.71	-4.14	2	110	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	90	102	36	118	21	113.60	54	68.56	CHANGED	.sRttapPQDpD.puCDYWRHCSIDGNlCDCsGGSLTsCPPGTcLusuSWVASCaNPsDGQoYLIAYRDCCGhpssGRCsClNspGELPVYRPEFsNDIlWCFGA-sDAMTYHCTlSPIVGKA	.........ts..........t.t.Ds.puCDYWRYCAIDG.LCo.CCGGohoSCPPGTpsSPsoWlGoChNPtDGpsYlIuYpDCCGKso.C.G...cChC.ps.Et.EpPlY+P...phsNDIsWChGsts....YpCosusllGh.....	0	7	19	26
+3310	PF04934	Med6	MED6; 	MED6 mediator sub complex component	Wood V, Bateman A	anon	Pfam-B_4045 (release 7.6)	Family	Component of RNA polymerase II holoenzyme and mediator sub complex.	20.20	20.20	20.20	20.60	19.30	20.10	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.89	0.71	-4.63	32	317	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	279	3	225	313	2	139.90	37	51.89	CHANGED	lpW+sPpalp....................h..sLp....ssNVL-.YFup..SPFYD+oSN...Npll+hQtphsp.................................................hppcLppMsGlEa.llsps..pEP...................................slaVI+KQpRps.............sspspslssYYlluuslYpAPslhsllsoRl....................hsslhplppu....hsphs.phspasP	................lpWpsstal.............................hLp.....ssslL-.YFup...sPFYD+TsN...Npsl+hQphh.p.......................................................................................cLppM.s..GlEY...llhps..pEP....................................lalIRKQp.Rps.................ssplhsLusYYIluu..s..lYQAPsltsVls..SRl........................loslpslppuhcpst.shspapP.........................................	0	76	120	183
+3311	PF03525	Meiotic_rec114		Meiotic recombination protein rec114	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	33.70	30.80	24.30	19.70	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.03	0.70	-5.94	4	26	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	25	0	15	25	0	261.40	35	69.83	CHANGED	YS+YTIPSaAPsGFsShLEPPpIDKWQHLSsNCTLQF+VLLhDStQlhlpVlLNNSThLEpIRLPLGsNpDhIQFSCKsPIISCKYISEEFGP+hL+RFQlNLPNDl-FNRslVSLKNLsFVl+TAKTSIApsThssQsps.NNupKlsFsEss.NsSoYppsNsQFQ............................TQNMlhDFSQphQEKstREssNpSNITLPpDs..hsIsQQpaPss-hNVVpoSQDLNTPpATQTlhupPEsL.VpshElSpshssooss.PshcNppppsthsSDhhS+Kthh.pp.sshhpshcLPKERpppEpplpuhh..hpsssThlhS.tppNpl+pNs	..................YSpYs....APpGFpohhpPs.pl-KWpH..l..S.ssssL.pFplLLh....cspp.lhlpV..lhN.........N.uslLEpIplP.l.....us.s.......p-lIQFSsKuPhISCKYlscch.usp...h.lRRFQhsLss-s-Fs+ssssLpsLsFVl+sA+...o..ohupsshps...phps.ps.spphsh..ps...phss..t..p.ph........................................................................s.s..h...sp....................................................................................................................................................................................................................................................................................................................................................	0	2	7	13
+3312	PF03243	MerB		Alkylmercury lyase	Bateman A	anon	Pfam-B_3505 (release 6.5)	Family	Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate.	21.00	21.00	24.00	29.60	18.90	20.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.70	0.71	-4.30	22	236	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	189	13	65	184	11	118.90	31	52.93	CHANGED	LolpPTsH+hpls..GcpLYsWCAlDsLhass.hlspssplpSpsssTGpslcloVcs.st...lsslpP.sssVVShl.ssss..s...sl+suhCs.hlpFFuo.psApsWhspHP...supllslt-Aa.pLGptlttplh	................hohh.TsHphpls.....u+.pLYuhCAlDoLhhsu.ll.u.p.s..sclpStCssTGpslplolps.s.p......lhslpP..sshsVuhlsssct.s..........shpsuhCs.plp.FFsS.psApsWhsp+s....th..tllslppAa.tlup.h.t..h............................	0	26	44	57
+3313	PF02065	Melibiase		Melibiase	Mian N, Bateman A, Eberhardt R	anon	IPR002287	Family	Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K [1]. This family includes enzymes from GH36A-B and GH36D-K and from GH27.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.45	0.70	-5.78	13	2958	2012-10-03 05:44:19	2003-04-07 12:59:11	13	57	1465	71	1044	2993	252	265.70	24	45.35	CHANGED	SFpTPEllhsYospGLNuhSQpaHsLhRp....+lh+statsc.RPlllNsWEAsYFDaNcsplhslA-cA.....tcLGlEhFVLDDGWFGs...RsDDsuuLGDWhlspcKaPsG...Lssluccl........+spGhcFGLWhEPEMVs.s-ScLa+pHPDWllp.sssRstopuRNQhVLDlups-VhDaIhpphspLLspssIDYlKWDhNRplTEssSsths.......ssHpYhLGlYclh-pLsspaPcllaEuCuuGGGRFDhGhLhYhPQhWsSDsTDAl-RlsIQaGTSL............lYPsushGAHVSAsPNcQstRtT.ShphRutVAhh.GshGhELDlspLsccEcptltp.lAhaKchRpllt.....hGshYRLpsPt..su.NpsAhhhVSsDpspAlltahplhussshs..........shl+LtGLDsc	...................................................................................................................................................................t..p..t...P..h.h....h.Ns.........W.p..s....h.........h....h.........c..........h..........s..........c....pt..........l..........h.p....h..A....c..th................tc..h.....G...h.......-.....h..h....l..l..D....DG...Wh.s..t.................R.p..s...c................t....................h.......G...........c........h......h......s........s..........t........p.......+a..P.....s.....G..........lpsLsct.l...........+..sh.G.h.c.F.Gla...h....p....s...................s...........t.........o......t.........h........h...t..t....a....P.....................................................................................................................................................................................................................tt.hh...t.......hta.hKh..D...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................s...............................................................................................................................................................................................................	1	383	695	892
+3314	PF01372	Melittin		Melittin	Bateman A	anon	SCOP	Family	\N	20.60	20.60	21.10	25.90	19.70	20.50	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.39	0.72	-7.01	0.72	-4.59	3	18	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	16	4	1	33	0	24.20	71	40.82	CHANGED	GIGAILKVLoTGLPALISWIKRKRQQ	.GIGAlLKVLuoGLPsLISWIKp.....	1	1	1	1
+3315	PF02964	MeMO_Hyd_G		Methane monooxygenase, hydrolase gamma chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	118.90	118.40	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.92	0.71	-4.33	3	19	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	18	54	4	20	0	160.40	53	94.31	CHANGED	IH-NsTRsAWhuKIApLNTLEKAscFIpDFRscHoSPFRsSY-LDlDYLWIEtKIEEKLAVLKs+cFN-sDLlsKsTsGEDApuVtsssVAKMcAAsDKYEAERIHIsFRQAYKPPVMPVNVFLDTDRQLGT+LMELRNTDYYATPLEuLRKcRGVKVVHL	......IH-NssRsEWhuKIApLsolcpAstFlpDFRhpaoSPFRpoYcLDlDa.aIEtKIEE+LuVLKscc.h.ssu-LlTKsosGEDAttVpsshlAKhcAscs+Y.EAERIHIpFRphYKPPVhPVNVFLcTDptLGT+LMELRNTDYYusPLEsLRKcRGVKVlpL.......	0	1	4	4
+3316	PF03203	MerC		MerC mercury resistance protein	Mifsud W	anon	Pfam-B_2720 (release 6.5)	Family	\N	23.00	23.00	23.00	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.74	0.71	-3.72	42	387	2009-09-11 08:49:01	2003-04-07 12:59:11	9	5	300	0	102	277	593	114.30	31	81.69	CHANGED	hD+hulshSsLCslHC...lshPhlhshLsshG.hhh.....hhsphhHphhlslslslullAlhhGhhpH+.phthhsluhhGlslhshuhhh.cshh.....ct...............................................slTllGssllshuHlhNhRhs	..................hD+hGshuSllsAhtC.hshPslsuhuuulG.uhh...............hcs............hah....th..lLslhssluhlA.slGa...hpH+.phh..hhh.L.uhlG.sllhsus..h.....hhhshhh.....ps.................................................................slhhlGhsLhlusplhshh..s......................	0	45	71	89
+3317	PF05052	MerE		MerE protein	Moxon SJ	anon	Pfam-B_5840 (release 7.7)	Family	The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2]. 	20.70	20.70	22.10	21.70	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.66	0.72	-4.00	6	198	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	160	0	22	56	10	73.70	75	93.45	CHANGED	MNSP-+lPsET+..pPlTGYLWGsLAVLTCPCHLPILsh..VLAGTTAG.AFluEaWGIAALsLTGLFlLSloRhLRAF...p	............MNuP-+LPsET+..pPloGYLWGALAVLTCPCHLPILAs....VLAGTTAG.AFlGE..H..WGlAALsLTGLFVLSVTRLLRAF.c........	1	5	9	16
+3318	PF00376	MerR	merR; 	MerR family regulatory protein	Finn RD, Bateman A	anon	Prosite & Pfam-B_3021 (Release 7.5)	Family	\N	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-7.41	0.72	-4.39	347	3063	2012-10-04 14:01:12	2003-04-07 12:59:11	18	35	1779	31	910	13735	1815	37.70	36	21.31	CHANGED	sIu-l.....Ach.s..GloscolRaY-ct.G.Ll...ssp+spsGhRhY	..............sIGcl.....Act.s.....GVsspsl...RaYEpp..G.Ll.....ss.tR..s..s..u..u.hRpY.................	0	354	658	814
+3319	PF02411	MerT		MerT mercuric transport protein	Bashton M, Bateman A	anon	Pfam-B_1796 (release 5.4)	Family	MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic  MerP (also part of the transport system) to mercuric reductase (MerE).	29.30	29.30	29.30	29.40	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.55	0.71	-4.28	3	490	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	366	0	109	326	70	112.50	47	88.93	CHANGED	MSEPpNsRGALFAGGLAAILASsCCLGPLVLlsLGlSGAWIGNLTlLEPYRPIFIuAALVALFFAWRRIYRPVcACcPGsVCAlPQVR+TYKlIFWlVAlLlLVAluFPYVlsaFY	......................psu+u...u...Lh..u.G....s..L.A.AlhASsCClGPLVLlsL.GhS.GA.WI.G....N......LT.s.LE.PYR.PlF.IGs...A.LlAL..h..FAWp+l...Y......R..P..s..p..A...Cc.....P.G.c.lC...A...l...Pp...l.R...t.........s....h...K.llF.W..l.VusLVLluLuFPYlhPaFY.........................................	0	32	75	97
+3320	PF02475	Met_10		Met-10+ like-protein	Mian N, Bateman A	anon	Pfam-B_2239 (release 5.4)	Family	The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast (Swiss:P38793) suggesting this protein may be involved in methionine biosynthesis, transport and/or utilisation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.28	0.71	-4.72	11	1002	2012-10-10 17:06:42	2003-04-07 12:59:11	11	35	540	11	661	9354	2050	197.00	24	47.12	CHANGED	psaslIGDllllplpsEhpp.acphIuEslhchp.slKsVhp+supl..cG.aRshchEllAG.ps.opTlH+ENGspa+lDluKVaaSs+htsERtRlsph.sc-GElVlDMFAGlGPFuIslA+htKschVaAl-lNPcuh+aLpENI+LN..KVcshl.sIhuDsc-Vh...cshAD..............................................RllMshPtpsccFLcp...Ahptl+-G............GVlHY	.......................................................................................................p..athhGc....l..h..h..l..p....h..........t....p..................t....t.....l.....u...p............h...l...h.p....t............t...l...c.s...l...h....p.c....h.s..........h......t..s..t..h...R................p....h.....c....l....l..h.....G....c...p.....................h..............s......h.pE.....p....s..h....p.....a...p...h..........D.....h......s....+.....l.....a....a.....s......s....p............t...s.............E......+........t.......R...l.......s........p................h.......h.........p.........t........s.............-.....s............V..hDh.a..AGl...G..s.....F......u.l....s...h...u.....p...............+....s....t....h.........V...aAs-......lNPp...u...h....c.......hL..p.c........N..h...p.....l..N.......+..l...........p.....s.........h.......l........s.....h.....p...h.....D.....s.....p...p....hh............hh..p........................................................................................................................................................................................+...h..l....h....s..h............................s..........p......h....h.......h....................................................................................................................................................................................	1	209	377	540
+3321	PF02965	Met_synt_B12		Vitamin B12 dependent methionine synthase, activation domain	Griffiths-Jones SR, Eberhardt R	anon	Structural domain	Domain	\N	20.80	20.80	21.50	21.30	19.70	20.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.16	0.70	-11.32	0.70	-5.14	11	2573	2009-09-10 23:08:37	2003-04-07 12:59:11	12	20	2384	10	722	2189	810	252.90	35	25.51	CHANGED	sslpElhsalc.+shap.......................s.t..stcsp+lh.supshLp.........ucslsshLsu.........................................................................u-hhuhFAsTuGhthEchtcshppptD.hpuhllcAlGstlAEAhA-plcccl+pc....stscslsho.........hR.uPGYsuh.-hoEpttlapLlpsEp.hGl+LT-ShhMsPtpSVSGlhhhsPp.u+h.hhuphspsphpDhhtRKth	.............................................................................................................................................................................................................................................h..ltplh.aIDWtsFF..sW..........ph.hG.a....................Ptl..h..pc....G....tA.ppla.t-u....pt..hL.....c.cl.tpphl..........ps+uVhGha.PAspsGDDl.lhtscsppphhth.h.......................................................................................................................pp.thsshsluDalssh.oGhs..DalGh.FAV..TuGhth.-thscta.c.sp..p.DDYstIh.l+ALADR..LAEA......hAEhlHc+VR+c..hW....GYus.sEsLss--Llp.....................ppYpGIRPA.PG.Y.P.A........CP-Ho-Ktsla.cLL..c..........s..-.....c..h.......G......hpL.T.E.S.a.AMhPsuSVSGhYau.H.P.c.....u.....+...Y......F.....u.l..u....p...l.tpD.Q.l.p.c.aAhR+t.....................................	0	250	478	616
+3322	PF03724	META	DUF306;	META domain	Yeats C	anon	Yeats C	Domain	Small domain family found in proteins of of unknown function. Some are secreted (e.g. Swiss:O25998) and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene.  Over-expression in L.amazonensis increases virulence (Swiss:O43987; [1]). A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.50	0.72	-4.18	122	2207	2012-10-03 08:47:39	2003-04-07 12:59:11	11	29	1689	2	524	1564	142	100.60	23	59.33	CHANGED	sltsspWpl......h..put.shhs...tpps...pls.........h.tss.................s...plsGp...uG..CNpahGsapl.pss..........p.....lshs....sluuTchuC..s.s.hhphEpthhpsLps.spshpl.p..ss............pLsLps	..........................................................................ttpa.l..........h....p.ut...hs.t.............psts....pls.........h..s..pp...................t....plsGp.....su..CNp..a.....h..Gp...h.p.......l...ps.s..........p.......lphp....sl.u.s.T.c...Mh.C......ss.....p..hhphEpphh.p.hLpp..stphsl.s......ss.............pLhL..t...............................	0	156	334	437
+3323	PF01676	Metalloenzyme		Metalloenzyme superfamily	Bateman A	anon	Pfam-B_1926 (release 4.1)	Family	This family includes phosphopentomutase Swiss:P07651 and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, Swiss:P37689. This family is also related to Pfam:PF00245 [1]. The alignment contains the most conserved residues that are probably involved in metal binding and catalysis.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null --hand HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.65	0.70	-4.99	27	6157	2012-10-03 20:55:17	2003-04-07 12:59:11	13	22	3518	49	1368	5458	2001	425.30	23	96.34	CHANGED	pphlLllLDGhG.tsspc...tssl..psApT.........PshDplhc.........sspGhtlslP..uphGsS-luHhsl..............huhpstchasspshhtshsc....tt...........Glco+.sclthhsphst.c......hhllhDtR..cl.sppspshhcpltp.pltph........l....s..h...........h.tpuacshhltps....ts.ssshlcs...........lsPphl....stshh.hpss-sl.hhsacsc+stplhptlhppsach.hpptth..t+lh...hh.atuph.ushhh..sstshsph.hchhsppsl+phtluETtphs+lshhas..............h.l.sspGsThslpschpuhthscphlcsl.tsca.D.hlhlNhsssD.hsGHsGchcuplculEthDp.plscll-tltpssshlllTADHGNs.phhs..................TtHTtcPVPlllhut....sh+.......hsphh.tsphAsluuTlhplhGhchsp.hpsh	.....................................................................................................................................................................................................................................................................................................................................................................................................hhLlllD..u...hG...h...stttc................sssh..........tsA.ss.......................s.shsclhpt...s................t.t.p..G...h..s...l.s...LP....sphG.uc.l.u.+hshussphshpshschstthppsphhpsstht.hhthhhssstshhhhshhssttsppp.pthhthhphstttsh.t.h.....................................................................................................................................................................hh.t.httsthhhhpsssshhhhhtpcshthtphhhhhpphttphpttthhhhthhhhhhhssp.sshhth.s.p.s.hss...p..s.p.h.h..s...h...p..t...l..p.p.....h..t...h....u-s.....phu..+.ls..h.asG...............................................................................................s.p.s..h...T...h..c..lp..s..c....h....u..s....h....cl...h..-...th.................l.................c.t.l............p..................p......s......c...............h....s......hl.h.sNhs..shD.hhGH....p....t.............s...h.....p....u...h...h..c..A..l.E..shDp...pl.s.c...l...h....c....t.....l................p.......p......s......s......h......l....l..I..T.A.DHG...N..s.s.phts........................................................................................T.s.H....T....p....p................V.....P.....llh.h..us.............th.p........................s.s.p.l..t.p....t..s...p...h....u..D..l.usTlhphhuhp.sp.hpu.h....................................................................................................................................................................................................	0	517	943	1184
+3324	PF02066	Metallothio_11		Metallothionein family 11	Mian N, Bateman A	anon	IPR000869	Family	\N	21.40	21.40	57.30	56.80	18.50	16.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.18	0.72	-4.09	2	7	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	1	0	7	7	0	54.10	63	100.00	CHANGED	MEFToAhFGsSLl.op.pTppKHNLVssCCCSpsTpcso...SCsCoKCuCcoCKC	MEFToAhFGASLIpop....pTppKHNLVNsCCCSpsspcso...SCsCoKCuCcoCKC.	0	7	7	7
+3325	PF01439	Metallothio_2		Metallothionein	Bateman A	anon	Prodom_1611 (release 99.1)	Family	Members of this family are metallothioneins. These proteins are cysteine rich proteins that bind to heavy metals. Members of this family appear to be closest to Class II metallothioneins, seed Pfam:PF00131.	23.00	23.00	23.30	23.30	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-11.06	0.72	-3.43	23	407	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	153	0	53	379	0	72.40	50	90.61	CHANGED	M.SC.CGu.sCGC..GSu.CKCGssCs.CpMYPDls.pt.soTo..pTllhGVAPpKs...puuEhuss...ussGCKCGusCpCsPCsC	..........MSC..CGGsCGC...GSu.Cp.CGss......ssKMYPDls.pt...soTo...pTllhGVAPpKs..phE...u.s.....Ehusst.....sssG.....C.K.CGs.sCp.C.s.PCsC................................................	0	2	22	40
+3326	PF02067	Metallothio_5		Metallothionein family 5	Mian N, Bateman A	anon	IPR000966	Family	\N	25.00	25.00	25.60	25.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.01	0.72	-3.91	2	57	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	16	0	28	47	0	40.30	57	94.64	CHANGED	MsC..CGosCpCuuQtstssCsCspDCpCsscptststCsp	MsCKuCGTNCpCoupK.CGsNCuCspDCpCsCKN.GPK-pCCp....	0	4	5	19
+3327	PF02068	Metallothio_PEC		Plant PEC family metallothionein	Mian N, Bateman A	anon	IPR000316	Family	\N	26.80	26.80	26.80	29.50	25.60	26.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-10.77	0.72	-3.61	4	37	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	20	3	16	36	0	72.90	53	73.21	CHANGED	GCDD+CGCssPCPGGsuCRCsSu...puuuGstEHpsCsCGEHCGCNPCsCs+spspsSG+u..+ApCoCGsuCsCASCAS	..........hCs-+CGCslPCPGGs......sCRCsus.....tuuu.Gs.s-HsTCsCGEH.CGCNPCsCsKs..tsoGpG.....CpCGsuCsCAoCu....	0	2	11	13
+3328	PF02069	Metallothio_Pro		Prokaryotic metallothionein	Mian N, Bateman A	anon	IPR000518	Family	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.47	0.72	-4.14	13	100	2012-10-05 18:33:37	2003-04-07 12:59:11	11	1	96	1	39	94	51	47.90	40	73.21	CHANGED	oTsTphKCACssChCsVohssAlp+-GKsYCSEuCAsGH.hsspGC....GHsGCsC	................pCACssCsChVs..scAlp+-G+hYCscuCAsGH..psps.C....tpssCtC.........	0	8	21	32
+3329	PF00131	Metallothio	metalthio; 	Metallothionein	Sonnhammer ELL	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.81	0.72	-11.32	0.72	-4.09	21	581	2012-10-05 18:33:37	2003-04-07 12:59:11	15	4	201	21	109	522	0	58.90	56	96.13	CHANGED	.DP......CsCtc.susCsCus.uCp.CpsC+CssCcKss.ssCssuGC...sKCu..psCsCtt......t..pCoCCs	......MDP......CsCsp....uG...oC..sCuu..S...CK.C.c.sC+C.....TS.C.KK..S.C..C.uCCPsGC....sKCA...pGC..l..CKG......tspcCSCC....................	0	14	17	30
+3330	PF01717	Meth_synt_2	Methionine_synt; 	Cobalamin-independent synthase, Catalytic domain	Bashton M, Bateman A	anon	Pfam-B_1909 (release 4.1)	Domain	This is a family of vitamin-B12 independent methionine synthases or 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferases, EC:2.1.1.14 from bacteria and plants. Plants are the only higher eukaryotes that have the required enzymes for methionine synthesis [1]. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to homocysteine [1]. The aligned region makes up the carboxy region of the approximately 750 amino acid protein except in some hypothetical archaeal proteins present in the family, where this region corresponds to the entire length. This domain contains the catalytic residues of the enzyme [2].	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.06	0.70	-5.46	14	4790	2012-10-01 21:20:02	2003-04-07 12:59:11	13	9	3434	28	1233	5086	1353	308.90	33	54.56	CHANGED	hPTTT.IGSaPQTsclRcsRtphppuplu..tpYpsth+ttIcpslchQEclGlDVLVHGE.ERsDMVEYFupplsGh.shTtsuWVpSYGSRsh+Pshhhuclptspsholc.thhupshsscs..VKGhLTGPlTILsWSFsR...pD.s+cshshQlAlAL+cElt.cL-sAGhtlIQlDEP...ALREGlPLpp..tc.stYhpWultuFRlssssstscsQlpoHhCYSpassIh...stIsshDsDVloIEtu+sc.phlsslpc.htas+plG.GVaDlHSP.+VPSsEEltshlpcshch.........h.t-pLWVNPDCGLKTRshpEshsuL+NMVcAAct	.....................................................................................................................................................hPTTT..lGSF..Ppop..p.....l.......+..p.....h.......R..........t..t........a.......p...............p..G..p......lst...ppapphhp...........ppIpphl......phQEclGL.D.VllcG....Ehc..R....s....-..............h.Vp.a...F.u...E.p....L.........sGa....h..............h.......s..............p....p...............u.............a..........V...............Q......u....a.............G................s................+................s.............s....+.....s.............P...l..........l....h.....G...-.l........s....p...s.....p..s.....h..........s.......V...c......h.....s......p.a.......u.p.....u.h....T.s+s...............h..Ku.....h...L......T..G......P......s......T.....l....l.....s....h.....o.a.....sR................pt......s...pc....p.....hst..........p.l...A...h.....A.....l...+-El.t......cL.c.s..A.......G.l............p.l.......I.QlDE...s........................Al..+..E.t.....l.....Ph+p..............tc...h....p..t...a.....L............p......h........u............l........t.......u........a...........p............l.......s....p..........u......s....s.........t..........s..........c.....s......p..........I..p...T..........H.h..C...........Y..................u..........p...........F...........s..........shh.................st.l..s.....s..h.....c..s....Dl..l...o.....l..E..s...u....c....S....c.............h.............p.............h...l..........c...sh.....c......p.....h........s..h....s..p..c...l..G.....GVh..D....l.+....S....P.....c....l...P....s.....h.-..c..lt..s.h.l.c.cu..hph..........................lsh..c..pl...alsPD............CG.......L........p......o......p.......t......h.............ps......h.....tt.Ltthltssp.t.......................................................................................................................	1	360	749	1029
+3332	PF01035	DNA_binding_1	Methlytrans; Methyltrans; Methyltransf_1; 	6-O-methylguanine DNA methyltransferase, DNA binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1191 (release 3.0)	Domain	This domain is a 3 helical bundle.	21.30	21.30	21.50	21.40	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.97	0.72	-4.24	93	7975	2009-09-12 05:33:12	2003-04-07 12:59:11	15	49	4422	25	1944	5717	2191	84.40	39	44.75	CHANGED	osFpppVhpt...ltp.IPhGplsoYuplA....ctlG.p.....spuuRsVGpAh...spNP....hshhlPCHRVlsusGp.......lusa....th........uhth..Kp.tLLptEuhth..p	................................osFpppV.Wps.Lpp..IP.hGpshoYuplA................ptl.G..p................P.p..A..sRAVG...s...As........upNP.................lul.ll..PCHRVlsssGp.........L.s.Ga..........ss......................Gl.pc..Kp..tLLphEuh...t...........................................	0	624	1221	1628
+3333	PF02870	Methyltransf_1N	Methlytrans; Methyltrans; 	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1191 (release 3.0)	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.44	0.72	-3.38	11	2628	2009-09-14 13:10:39	2003-04-07 12:59:11	10	12	1908	11	442	1666	131	76.10	23	35.10	CHANGED	tlhaohhcoPlGplhlsssEcs.lptlthtspshs......h.t..phhhts-......hsshthhppplcpYhAuptp.....thslPlch	....................................t.hhhthh.soPlGtlhl.s.s...s-....p.....u..Ls.ulha..tspptp.............h.ph..ph..h...t..sc......................ts...h....t..th...p...p.....pLcc...YFuGppp......hslPls..............................................	0	118	236	347
+3334	PF00891	Methyltransf_2	Methyltransf;	O-methyltransferase	Bateman A	anon	Pfam-B_152 (release 3.0)	Family	This family includes a range of O-methyltransferases. These enzymes utilise S-adenosyl methionine.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.42	0.70	-5.18	30	3396	2012-10-10 17:06:42	2003-04-07 12:59:11	13	42	1164	67	1586	4681	447	220.60	22	62.75	CHANGED	tps.........phYshsssuchLhsspss...sshsshhhhhtspshhpsWtpLp-..ulh-Gt.....ssFpcsaGhs..ha-ahus.Ds...chsphFspuMssssslhs.hchhpshpsFpslsolVDVGGGsGsssptIsptaPpl+uhsFDLPcVltsAss.......tssVcaVuGDhF.-slPp..ADAllLKalLHDWuDpcClclL+pChcAls...tpG+VlllEsllspssssshps...........hhhDlhMlshss.G+ERoccEacpLhp	.........................................................................................................................tttt......................h..................................................................h.............h.............h...tp.......h........p..st...................s..h.t...h..h.h...s....s....ha.ph...h.t....p...p.s..........phtp....h.......F..t......p..u.M.......t.........s..............s........t.........h...........h........h...............................h.......h.................t....h.........h.....s.....h.........p...........s......h........p................p.............l..l.DV.....G...G.G.p...G....t.h...h...t..t.l..h....p.....t....a..........P....p.......l.......c......s....h.....l..h...D.....L.....P...p.....V.....l...t.t..utt.................................ts.p.l...p...h..h...u...u...D...h.....F.....p.........s.......l......P.........t......u.......D.........s.....h......h...h.p.....h.............l....L.............H..c...........W.....s....D.....c....p.......s...h.p...l...L.ppst.p.A...hs........t.........u...+...lllh..-h.l...h..sp...t.....t...t.....t..............t..t......................................h.h.c.h.h..M..hshhs...Gp.....pRs.tcattlh.................................................................................	0	329	890	1294
+3335	PF01596	Methyltransf_3		O-methyltransferase	Bateman A	anon	Pfam-B_749 (release 4.1)	Domain	Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase Swiss:P21964, caffeoyl-CoA O-methyltransferase Swiss:Q43095 and a family of bacterial O-methyltransferases that may be involved in antibiotic production [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.17	0.71	-5.27	8	3858	2012-10-10 17:06:42	2003-04-07 12:59:11	12	23	2673	61	1074	4599	1860	191.10	25	85.30	CHANGED	h-oSsh..Es-hL+ELR-tTs+pP..hstMplss-EGQFLuhLl+LhsAK+TLEIGVFTGYShLssALALP-DG+IsAhDlscEshplGhsaIQKAGVscKIshhlGDAhpsL.-pLhp-cp..spFDFsFlDADKsuYspYaE+hLcLVKsGGLIAhDNTLWtGpVs-s.-sssP-shp.....lhchNchLusD.RV-IuhLslGDGITLsRRl	.................................................................................t...................................................h...........l.s...p..p.u....p..h.L.p.h..L...l.....c...h..h...p....s...+....p.....l......L...E.l.G.....T.hs.G...YSu....l...h.....h...A...p.......u..............l...........s........p........s............u.........c.....l......s...Tl....-...h.........s..t.........c........h....h...p..........h......A........+....p......h.p....c......u....s...........h......p......p...........c.................l...p...l..h............G.......s..A.....h..-..s......L......s.....p.............L...h..........t...........t............................s...a...........Dh.l......F............l.D............u........s..K............s.......p........Y...h......p......a.....h........p.......t..h..l..........p..........L.........l.c....s..G.G......l....l......l.s......D......Nl...............l....h......t......G.....t.....l....hp......t..........t........p..t.t......................lpph....c...h...l....h...p....p....p...hp...s.s.hl.sls.....DGlh.h.h..t................................................................................................	0	347	681	901
+3336	PF02390	Methyltransf_4		Putative methyltransferase 	Bashton M, Bateman A	anon	Pfam-B_1023 (release 5.2)	Family	This is a family of putative methyltransferases. The aligned  region contains the GXGXG S-AdoMet binding site suggesting  a putative methyltransferase activity.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.20	0.71	-5.26	19	4759	2012-10-10 17:06:42	2003-04-07 12:59:11	12	26	4414	24	1194	8689	3879	194.50	28	77.49	CHANGED	hP........ph..........Datphasp.s...........................lhlEIGsGhGshllshApppP-h.alGlElchsslttshp+htph........thpNltllptsAhphhpphhs.spLp+lhl.FPDPW.KpRH+KRRllpsphlpthtphLt.GGhlhhtTDspshhc.hhcthpp.............................shhphh................pss-h..sPhs........s.htssTchEp+shptstslaphhFp+h	........................................................................hs.htt............hchp.p.h.F.s.p..ptP...........................................lhlEIGhGhG....phl....s.......t.h..........A.....p........t....p...P..-.........h.........s..a.l.GlEl.....p.ps..sl...s.....t.....s..L..pp.h.tct............................................................sl.s.N.......l..+..l..l....p...t...D......A....h.....c.....l......L...p.....p...h.....h...s......p......s....p.....l.s....p..l..a...l.....h...F........PD..P..W.....K....p....R.Hp.............KR........R...........llp.....sFlphhtph..L.p.........s..............G.....hl....+.ht...T...D..csh.h.cahL.cshsp........................................................................t..hp.t.h..................................................s...c..h.........s...s.h.............t...p.shTcaEp....+hpp.t.Gpslaclhh...h......................................................................................................................................................................	0	408	771	1016
+3337	PF03737	Methyltransf_6		Demethylmenaquinone methyltransferase	Bateman A	anon	COG0684	Family	Members of this family are demethylmenaquinone methyltransferases that convert dimethylmenaquinone (DMK) to menaquinone (MK) in the final step of menaquinone biosynthesis. This region is also found at the C-terminus of the DlpA protein Swiss:Q48806.	20.70	20.70	22.30	21.90	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.54	0.71	-4.35	11	3287	2009-01-15 18:05:59	2003-04-07 12:59:11	10	22	1989	41	1060	2581	1112	153.90	30	75.23	CHANGED	pphsTssLsDshst.sssspPhhss...hstpsphsGpssTV+shp..............DNsLl+pslppsutGcVLVlDGtGsh..........cpAlhGshluthAtppGhpGlVlaGslRDlsslcpLDlslhAhussPst..usppuhGp..lsVslshuGVT..lpPGDhlhuDssGllV	............................................................................................sstl.D......h................p.....h.....t....h..h.p.......s...hps.......hss..p...s.p...h.sGphhTV+sht..........................DNs..h....l....p..c..hl.....-..p.....s.s........t........G...c..VLV...l...D..u....s.....G.s.h.....................cp.A..l.hGs.hl.A.p.h.A.h.p.p.Gh....t.GlVlp.G.u..VRDlspl.p.p..h.....s..ls..l..h.A.h..u..s.h.Phs.................s.s.p..c...u..h.G-.............hsls..l..........s..................h..........G...................G.......ls................lhPGD.hlhAD..s.sGll..............................................	0	248	604	862
+3338	PF03492	Methyltransf_7	Methytransf_6;	SAM dependent carboxyl methyltransferase	Bateman A	anon	Pfam-B_1148 (release 7.0)	Family	This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-Methylxanthine. Caffeine is synthesised through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N.  The protein 7-methylxanthine methyltransferase (designated as CaMXMT) catalyses the second step to produce theobromine [1].	20.20	20.20	20.30	20.90	19.80	19.30	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.15	0.70	-5.68	23	707	2012-10-10 17:06:42	2003-04-07 12:59:11	10	4	157	8	380	728	190	269.90	29	87.55	CHANGED	lppslpph....h.ts...hssslslADLGCSSGPNTFhslssIlcslcpphppps.....tssPEaplahNDLPsNDFNTlF+hLP.h..................tphFsuGVPGSFYGRLFP+pSLHhsaSSaoLHWLSpVPctlp-p.s..h.....NKuplahs.........pVh+AYhsQFpcDhshFLcsRuEElVsGGhMlLshhGRps.......D.ssptss..hhh-LlupuLsDlspEGll---KlDoFNlPhYsPsspEl+thI-cpGSFpI-chEhhp.....h..p....................tsucthusshRAlhEshLssHFGpslh-clFc+atp+lspph.hpp...p.hhsllluLpRp	..........................................................................h...................sp.hhlADLGCSsGsNohhhlppllphlpphhpp.t....................chphhhNDLssNDFNslF.p....t.L......sth.t....t........................shahsu...l.PG.SFY.s.R.LFPppSlchhaSuhu............Lp.W.L.....Sp........l.............P..ptl..s................................Ncsplahs..sss.....tlhpuYhpQappD.h.p.FLphRupElhs.GGthllsh..h.u+ps.................p....p.t.t.ts............hhp....hl...ttulpph.........stc....G........hl....pc-ch.-sFslPh....Ytso.pE.l...ct....hlpp.....p....u...p......F...p...l.p...p.hc..hhp..............h...................t.........................u.thu.th.hR.uhhpsh.l.......t...p.....h.....G........t.......t........l....h.c.tlFtphtphhtt......................................................................................................................................	1	54	213	296
+3339	PF02086	MethyltransfD12		D12 class N6 adenine-specific DNA methyltransferase	Mian N, Bateman A	anon	IPR002294	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.83	0.70	-4.93	27	3733	2012-10-10 17:06:42	2003-04-07 12:59:11	10	25	2224	21	654	3159	1250	233.30	24	80.29	CHANGED	ahGuKppLlspIpchlPp......ptppah-PFsGuGuVhhph......phtpslhNDlps.lhslap.llcs.........scpllpphp.h....hh..p..ssp-hahph+............pchN....pshp.h.c......sh.hhhhsthshsslhphsppupasssaGtatp......hhstpplpthsptlps.....sphhstsh-tshhhh.phts.hlYhDPPYtshp.tssapsapp.shspppphthtshhcpht....tphthphhlsss.......ssp.hcclaps...hslhphpthpsl	...................................................................................................ahGuKhtLhsp.l.......hp...h.lP....................ptpph.lEPFsGuG..uV.hh.ph...............php.p..h..l.l..s..Dlssc..Llsl...a.p.....hlpp.............................pspp.h.l...pthcth....................h..............s...p.pc.h.ah..ph+...............................................................................................pphs............p.th..p...h.c..........................uhhhh.a..l.s...+.h..s.....a.......sG.l..h......c....h....s........h.......p....u......p.....h........s..s....s.....h.....u.....p.apps....................hhs....p...p....p..l...h.t...h...s...p..p..hpp......................sthhst..s.a......p..........p.....s...h......t............t......h..............t.......t......s.....s.......l..lY.h.DPPY......h.s..........................ts............s....a..p.......t.....a....p..t.t....s.a.s.........p.......p....p..h..p.L....t..p....h...h.pph................t.th...h...hlSsp....................ss..h+phapt......th........................................................................................................................................................................................................	0	232	454	559
+3340	PF01340	MetJ		Met Apo-repressor, MetJ	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	31.60	31.50	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.33	0.72	-4.28	3	798	2012-10-02 18:44:02	2003-04-07 12:59:11	15	1	794	30	96	197	8	102.70	87	97.11	CHANGED	AEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMRELGIDPETWEY	.....AEWsGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPsDsDLRKERSDEIPEAAKcIMREMGIsPETWEY..............	0	12	33	66
+3341	PF04648	MF_alpha		Yeast mating factor alpha hormone	Kerrison ND	anon	DOMO:DM04511;	Family	The hormone is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It inhibits DNA synthesis in type A cells synchronising them with type alpha, and so mediates the conjugation process.	19.00	19.00	24.60	19.20	17.90	16.20	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.97	0.73	-6.12	0.73	-3.43	3	152	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	27	0	59	116	0	13.00	78	26.85	CHANGED	WHWLSl+PGQPMY	WHWLpL+PGQPMY.	0	6	30	45
+3342	PF04202	Mfp-3		Foot protein 3	Bateman A	anon	Pfam-B_1860 (release 7.3)	Family	Mytilus foot protein-3 (Mfp-3) is a highly polymorphic protein family located in the byssal adhesive plaques of blue mussels.	20.70	20.70	21.60	23.10	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.69	0.72	-3.80	2	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	5	0	1	49	0	71.80	63	96.17	CHANGED	MNNoSVSVLVsLVLIGSFAVpSDAAsYYGPNYGPPRRYGG..YNtYNRYuRtYGG.+GWNpGWpRGhRG+h	..MNNhSVuVL.lALVLIG.FAVQSDA..u.......hhYsPsYssPh.YssGh..Y..NGYNtY.tt...RYGhNKGWNsG.W...................	0	0	1	1
+3343	PF01078	Mg_chelatase		Magnesium chelatase, subunit ChlI	Finn RD, Bateman A	anon	Pfam-B_616 (release 3.0)	Family	Magnesium-chelatase is a three-component enzyme that  catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of  (bacterio)chlorophyll.  Due to this, it is thought that  Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.14	0.70	-5.16	56	4229	2012-10-05 12:31:08	2003-04-07 12:59:11	16	28	3288	9	1225	9364	2476	172.30	42	36.05	CHANGED	DhsDV+GQppA+RALElAAAGGHNLLhlGPPGoGKoMLApRLPulLPPLotpEuLEsstItSluG..thptshhppRPFRuPHHouStsALlGG..Gs.hs+PGElSLAHpGVLFLDElPEFsRplLEsLRpPLEsGclsIoRAptpl.saPAcFQLVAAMNPCPCGahucssptCpCo..spphpRYhu+lSGPLLDRIDlplcV.stlshtpL	.............................................................................................Dht-lhGQ....t....p...u....+....R....A....l....c...l....A...A.................A.............G......t.......H.............s...l..l..hhG..sPGsGKoM.LApR.l......s....s......l......L....P.................s..............h...s.....................p............E............h..l............E...........s..s.......t...........l....h.........S.......ls.......s..................................t.....t.......h...t...p.t..............P..F...Rs....P.........H..........H.....os.........S.............s.A..l........l...G.......G..................G...........s...hspP..G.....E.l.o...L....A....H.p..G....V.LFLDEl...sEF...pcplL.-s.L.R..pPl.Es..G..p.l.p.lu....R.s.t....t........p....l........p........a....PA+F.LluA.hN.....PsPsG....h..t...t.....t......t.t..C...s.........stph.cY.s+..lS..GPhlDRhDlplph.......h...................................................................................	0	414	845	1059
+3344	PF05043	Mga		Mga helix-turn-helix domain	Moxon SJ, Bateman A	anon	Pfam-B_5126 (release 7.7)	Domain	M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1]. This domain is found in the centre of the Mga proteins.  This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci.  These proteins have been shown to regulate the expression of important bacterial adhesins [2]. This is presumably a DNA-binding domain.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.76	0.72	-3.70	33	5627	2012-10-04 14:01:12	2003-04-07 12:59:11	8	55	1351	2	389	3825	25	88.20	19	15.90	CHANGED	tshshpplhphhhcc...............ShphplLphlh..tpcphslpphupchalSpoolhRhlcclsphLp.paslpl.....pssplh.GcEhpIRhFahhLa	.........................................................................t..............pp..................phph.h...l.l..phl....h......tppth..shp..p.lspchhlScuTl.h+clppl.p.p.h.Lp...pa..s..L..pl.........ttps...h..p..l..h..GsE.hpl.Rhhhhph....................................	0	126	235	307
+3345	PF05220	MgpC		MgpC protein precursor	Moxon SJ	anon	Pfam-B_6685 (release 7.7)	Family	This family contains several Mycoplasma MgpC like-proteins.	18.30	18.30	21.50	24.60	17.90	16.50	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.49	0.70	-5.23	3	49	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	7	0	9	57	1	203.40	69	29.95	CHANGED	MGSstVPSLWYWVV...uE-ssSGKuTWWA+TELNWGTDKQKQFVENQLGFKETSuTDSHN..FKupuLTQPAYLISGLDVVADHLVFAAFKAGAVGYD...MTTDSSASTYNQALAWSTTAGLDScGGYKALVENTAGLNGPINGLFTLLDTFAYVTPVSGMKGGSpNTEsVQTTYPVKSDQKATAKIASLINASPLNSYGD-GlsVFDALGLNaNFKhN-ERLPSRTDQl	.....MGsshlPSLWYWVV...upcssSsKsTWaApTpLsWGpDKQKQFVENQLGaK..-souosSHN..F+SpuhTQPAYLISGlDsVsDpLlFuuFKAGuVGYD......So.SSuS...TKDQALAWSTTsuLDScsGY+sLVpNssGLNGPING.Fol.DTFuaVsPhSG.+sss.ts...o.tslpTsYPVKsspKuTsKIsSLINAoPLNSYGD-G...lsVFDALGLNaNFK.NpE+Lspt................................	0	8	8	8
+3346	PF02308	MgtC		MgtC family	Bateman A	anon	Bateman A	Family	The MgtC protein is found in an operon with the Mg2+ transporter protein MgtB.  The function of MgtC and its homologues is not known.	23.00	23.00	23.20	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.71	0.71	-4.32	11	3455	2009-09-11 06:02:09	2003-04-07 12:59:11	11	7	2432	0	775	2251	137	132.60	37	56.32	CHANGED	LllAhllGulIGLERphRt...+hAGLRTpsLlAhGuslhsllSlpsthshs.........PsRlsAQllSGlGFLGuGsIL+cu........sslpGLTTAAolWsoAulGllsGuGhaphulhuolhlLh..lhLpslsphlp+p.hp	.........................lhlAhllGulIGhER..p.h.....+p..................+s.AGlRT.ahLVu.lGuslh...h......l.....l.u.......hh....s....h....t.s....h..........................DPsRlu...A....QVV....SG.l.G.F...L.G.A..G..s.I..l..h.ps...............................ps.l.pG...L.TTAAslWsoAulGls.h..G.s.G..h......ahhA.lhusl.h..ll.h.s.h.hh..lp...ltp.......hht...................................	0	254	503	630
+3347	PF03448	MgtE_N		MgtE intracellular N domain	Bateman A	anon	Bateman A	Domain	This domain is found at the N-terminus of eubacterial magnesium transporters of the MgtE family Pfam:PF01769. This domain is an intracellular domain that has an alpha-helical structure. The crystal structure of the MgtE transporter [1] shows two of 5 magnesium ions are in the interface between the N domain and the CBS domains. In the absence of magnesium there is a large shift between the N and CBS domains.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.29	0.72	-3.70	169	3637	2012-10-02 13:19:07	2003-04-07 12:59:11	12	24	2860	12	968	2783	1850	101.10	22	23.58	CHANGED	hcssDlAcllp......pl...s..ccphtlhphL.stcptu-lhppls.tc.hptpllpph..sspphsp.llpphssDDtsDl...lpcLspct.tpplL...sth.stcc+pplppLLsYs-c	.....................................................pssDlAphlc......pl......s..cp....ph..hlh.ph.L....ss-p...tu-ll.p..pl...s...pc...hp...tpl...l...p...p...h...sspchu.c...llp...phss..D..-ss-l...lpcL...s...p.sh....hp...pl...L...s.th...s.cctpplpp.lLp.Ys-p...........................................	0	358	675	840
+3348	PF03165	MH1		MH1 domain	Bateman A	anon	Pfam-B_519 (release 3.0)	Domain	The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however.  Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [1,3].	25.00	25.00	25.20	27.80	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.70	0.72	-4.03	19	1320	2012-10-05 18:28:12	2003-04-07 12:59:11	11	19	119	10	608	1055	0	101.20	42	22.56	CHANGED	hc+sscuLlKKLKc+.....tL-sLhpAlpspGsss..................otClsls..............................+ph-uRLt............st+KuhPHllhC.....RlaRWPDLpptpELKslssCpts.hp.cpcp......lClNPYHYpRlp	................................................................t.pKhspsLl+KL+Kch...tthE-L.pAlo.....s....ps......................stCls.ls....................................................................................................p..h.ph.ts....................scpKGhP+lIhC..............+l..WRWPD..Lp..t..tELK...s...lt.h.C.phs..hphppst.............lC....lNPYHapRl......................	0	141	193	390
+3349	PF03166	MH2		MH2 domain	Bateman A	anon	Pfam-B_519 (release 3.0)	Family	This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2 [1-3].	25.00	25.00	25.10	25.00	22.20	24.60	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.32	0.71	-4.46	11	1087	2012-10-01 21:55:46	2003-04-07 12:59:11	9	17	139	31	549	937	0	167.40	50	39.60	CHANGED	hpcsphWsoIuYaEhssRVGEha+lsss...slhlDGas....Dss..sssRhCLGtLoNsNR..ssslppsRt+IGcGVpLshc..sGp..ValpspScpsIFVpSsshshptG.hc.s.pVpKlhPs.solKlF-hphhtpllppssppu.tu..................................stpLp+.hColRlSFVKGWGtcY.pRQslpuoPCWlEl+Lsts	...............................................................h.-PtaWCSIuYaE....hssRVGEsF+ssps.......ol.hlDG...as................DPS.....susRF..CLGhL...S.........N..V.s...R..............spslEp.sR.pHIG.+............G...VpLhhh..sG...-........VascC.l...S.............-.puIFVQ......S............sh.s..p....t.......G.....h...........+Ps.......s..........Vp...........K.......I.....................PG.........s.............s....l...K...............lFs.pc...htthh..tpss....s.p.u...ts...........................................................................V.pLp+.hC.ol.RhSF.VK.GW.G.s....-Y..pRQslouTPCWlElpLpt.s................................................................	0	143	186	378
+3350	PF00129	MHC_I		Class I Histocompatibility antigen, domains alpha 1 and 2	Sonnhammer ELL	anon	Prosite	Domain	\N	28.30	28.30	28.40	28.30	28.10	28.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.17	0.71	-4.93	25	25261	2012-10-03 22:02:01	2003-04-07 12:59:11	13	14	308	732	732	17686	0	155.50	62	74.51	CHANGED	GSHSLRYFhTAVSRPGhGEPRFIuVGYVDDTQFVRFDSDAtsPRhEPRAPWhEQEG.PEYW-RpTphuKuptQsFRVsLRTLhuYYNQSEuGSHTlQhMaGCDlGsDGRLLRGYpQaAYDG+DYIALNEDL+oWTAADsAAQIT+RKWEtAshAEp.tRAYLEGpCVEWLRRYLEpGKETL	......................................................................SHShRY..FhTu..h.S..RP..G..R..G..EP...R..FIu.V.G.YVDDTQF.VRF....D...S...D.A.s.S..........R.h.E..P.R...A.PW...l.....E....Q.....E.G......PE..Y.W...........D...c.p.T..ph.h.K...s.p.sQ...s..R.s.L.p.s....L..p.t.Y..Y.N..Q..S............E............u.......G............S............H......Tl.Qh.MYG.....CD..l...G....s...D...G....R...h.LRGapQ...AYDG+D..YIAL..N.E.D..L..+.SW.....T....A.....A....D.....h..A.....A....Q....I....T.......p...R.........K...W....E.......A..A...c.....A..EQ....h.......RAY...L.E.GpCVE.......WL....RR...YLENGKETL......................................................................................	0	92	131	319
+3351	PF03707	MHYT	SPNTR; 	Bacterial signalling protein N terminal repeat	Yeats C	anon	Yeats C	Repeat	Found as an N terminal triplet tandem repeat in bacterial signalling proteins. Family includes CoxC (Swiss:Q9KX27) and CoxH (Swiss:Q9KX23) from P.carboxydovorans. Each repeat contains two transmembrane helices. Domain is also described as the MHYT domain [1].	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.17	0.72	-3.86	27	2404	2009-01-15 18:05:59	2003-04-07 12:59:11	11	83	683	0	856	2299	124	61.50	27	23.87	CHANGED	GhGIhuMHasGMhAhph.........s..h.ap.hhhh.hSll....lultssssul.hhshttthhhthhhsusll	...............GhGIhuMHasGM.hAhphs...........................st..ltas...hh.......h.......s....h...l...Sll.............lA.l.ss.u.h.hAL....hhs..h..t....t.h............h.......................................	0	190	449	678
+3352	PF02426	MIase		Muconolactone delta-isomerase	Bateman A	anon	Pfam-B_2784 (release 5.4)	Domain	This small enzyme forms a homodecameric complex, that catalyses the third step in the catabolism of catechol to succinate- and acetyl-coa in the beta-ketoadipate pathway EC:5.3.3.4. The protein has a ferredoxin-like fold according to SCOP.	20.10	20.10	20.40	20.20	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.95	0.72	-4.17	7	493	2012-10-02 00:20:33	2003-04-07 12:59:11	11	4	392	0	136	363	26	90.60	44	92.14	CHANGED	MLFpVcMsVplPssMss-tAsplKucEKAhSQcLQ+pGKW.HlWR...lsGcYuNlSlFDV-SssELHplLtsLPLFPYMsIEVpsLsRHPSul	.............................................MLFhVcMsVpl.Psshssptsscl+AcEKshuQcLQcpG+Wh+LWR...ls.G..pYuNl.SlFDVcsssELH.s.l.Lp.uLPLa....P..a.M....sI.cV.ssLspHPSsl..................	1	29	70	109
+3353	PF03526	Microcin		Colicin E1 (microcin) immunity protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	25.00	26.40	23.70	24.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.50	0.72	-4.37	3	96	2009-09-10 20:23:55	2003-04-07 12:59:11	8	1	70	0	2	41	0	48.70	45	43.97	CHANGED	YYFLASDKMLYAIVISTILCPYSKYAIEHIAFKFIKK-FFc+RKNLNssPsAKls	..hhhh.hhhh.................lLaPhuKahIEchAlKFT+.-FWpps..FFssssGKhs.......	0	1	1	1
+3354	PF04687	Microvir_H		Microvirus H protein (pilot protein)	Kerrison ND	anon	DOMO:DM04728;	Family	A single molecule of H protein is found on each of the 12 spikes on the microvirus shell.  H is involved in the ejection of the phage DNA, and at  least one copy is injected into the host's periplasmic space along with the ssDNA viral genome [1]. Part of H is thought to lie outside the shell, where it recognises lipopolysaccharide from virus-sensitive strains [2].  Part of H may lie  within the capsid, since mutations in H can influence the DNA ejection  mechanism by affecting the DNA-protein interactions [3].  H may span the  capsid through the hydrophilic channels formed by G proteins [1].	21.30	21.30	36.80	61.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.93	0.70	-5.38	3	108	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	1	127	1	300.50	78	94.51	CHANGED	MGKLFGGGQSAsSsGIQGsVLAoDNNsVGMs.DAGIKSAIQGSNVPNSsEAAPStlSGlMA.......cAGKuLL-GTlQAGostVusKLlDtVGLGGKSAuDKGKDTRDYLAAAFPELNPWERAGAGASSuGlpDAGFpNQKELTKMQLDNQKEIAKMQNETQKEIAGIQSATSRQNTKDoVYAQNEMLAYNQKESpARVASILENTsLTKQQQTSEIMRQMLTQAQTAGQYFTNDQIKELTRKVuAEIDtVH..............Q-TQNSRYGSSQVGATAKDVSNsITDAASGlVDaF+GhDptVADsWNNFFKDGKScGIuSNpR+	............MSKLFGGGQpAASuGIQGsVLATDNNTVGMs.DAGIKSAIQGSNVPNscEAAPshlSGsMA.......cAGKuLL-GslQAGostVo-KLlDhVGLGGKSAADKGKDTRDYLAAAFPELNAWERAGAsASSAGMVDAGFENQKELTKMQLDNQKEIAEMQNETQKEIAGIQSATSRQNTKDQVYAQNEMLAYQQKESTARVASIMENTNLSKQQQVSEIMRQMLTQAQTAGQYFTNDQIKEhTRKVSAEVDLVH..............QQTQNQRYGSSpIGATAKDISNVVTDAASGVVDhF+GIDKAVADTWNNFWKDGKADGIGSNLSR....	0	0	1	1
+3355	PF04726	Microvir_J		Microvirus J protein	Kerrison ND	anon	DOMO:DM04878;	Family	This small protein is involved in DNA packaging, interacting with DNA via its hydrophobic carboxyl terminus.  In bacteriophage phi-X174, J is present in 60 copies, and forms an S-shaped polypeptide chain without any secondary structure.  It is thought to interact with DNA through simple charge interactions [1].	19.00	19.00	21.40	46.90	17.80	16.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.72	0.72	-6.88	0.72	-3.99	3	63	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	53	4	0	16	2	30.40	78	97.41	CHANGED	pKutRRSG.............GKRKGARLWYVGGoQF	...pKut+RSG.............GK+KGARLWYVGGpQF	0	0	0	0
+3356	PF04517	Microvir_lysis		Microvirus lysis protein (E), C terminus	Kerrison ND	anon	DOMO:DM04358;	Family	E protein causes host cell lysis by inhibiting MraY, a peptidoglycan biosynthesis enzyme.  This leads to cell wall failure at septation [1]. The N terminal transmembrane region matches the signal peptide model and must be omitted from the family.	25.00	25.00	50.50	49.90	17.30	15.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.82	0.72	-4.22	3	70	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	48	0	0	58	2297	42.00	67	46.41	CHANGED	pPVSSWKALSLsKTLSMASSARLKPLNCSRoPCVaAQETKpL	..RPVSSWKALSLRKTLLMASSVRLKPLNCSRLPCVaA.EThph.	0	0	0	0
+3357	PF04478	Mid2		Mid2 like cell wall stress sensor	Kerrison ND	anon	DOMO:DM04295;	Family	This family represents a region near the C terminus of Mid2, which contains a transmembrane region. The remainder of the protein sequence is serine-rich and of low complexity, and is therefore impossible to align accurately. Mid2 is thought to act as a mechanosensor of cell wall stress.  The C-terminal cytoplasmic region of Mid2 is known to interact with Rom2, a guanine nucleotide exchange factor (GEF) for Rho1, which is part of the cell wall integrity signalling pathway []1.	23.10	23.10	23.10	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.05	0.71	-4.81	6	122	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	88	0	81	123	0	108.60	28	28.33	CHANGED	sos.ssTI.TSlIcGpTILSstYTTlTYTPouTu..usss+ptpp.GLSKKN+NIVIGCVVGIGVPLllllLsLlYhFCIpssRTDFIsSDGKVlTAY+sN+hoKWWhsLLGKcl..o-cYpS-SPlGu.ssshps.tltpscDlhpsspshohctsss-up	..................................ss.....sh..o.oh...p.G..p..Th....h.s.sth..o...T...l....Th...o.sosos..........ss.s.sp.s...pso...G....L....Spps+.sIl.IGlVVG.lGs..sll.l.s.hlsll.ahhh..........................................................................................th........................................	0	14	46	75
+3358	PF01187	MIF		Macrophage migration inhibitory factor (MIF)	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.10	0.71	-4.00	6	669	2012-10-01 20:38:22	2003-04-07 12:59:11	13	13	403	152	326	668	118	108.50	27	78.19	CHANGED	PhhplcTNlPpspVPsuL.p+LostlApuhGKPtphluVclsPGttMsaGGSo-PCAlhSlpSIGsV.uucpN+SaoptlhchLscELplspDRlhIpFaDlpuuslGaNGoThu	...........................Phh.lpTN..l..s..h...s..p.h.s...p...s..lh..............p.c.h.sptl.uph.......h....GK....Pcsalh....lt.lp...sshshh..F...u..G.o.p.-.P.sAhs.pl..p..Sl.G.s..l...ssppN....cphottlsp.h.lppcLu..ls.t.s.R.halpahshpst..hGaNGssh....................................	0	106	186	263
+3359	PF03775	MinC_C	MinC;	Septum formation inhibitor MinC, C-terminal domain	Bateman A, Finn RD	anon	COG0850	Domain	In Escherichia coli Swiss:P06138 assembles into a Z ring at midcell while assembly at polar sites is prevented by the min system. MinC Swiss:P18196 a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with MinDE. MinC is an oligomer, probably a dimer [1]. The C terminal half of MinC is the most conserved and interacts with MinD.  The N terminal half is thought interact with FtsZ.	29.70	29.70	30.10	30.20	29.30	29.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.20	0.72	-4.40	15	2118	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	2070	4	484	1401	159	105.10	38	45.31	CHANGED	ThllcpsVRSGQpIYuc.GDLlllGsVssGAEllA-GNIHVYGsLRGRAhAGspGss.sApIaspplpuELluIuupahhs-c....lssphhscsspltlcs-tlhlpsL	.........hllcpsVRSGQplaut...uDLllhusVssGAElIA.cGNIHVYGhlRG.RA.lAGss......Gsp..pApIhsppL.pAE.LluIAGhYhh.u-p.......lssp.....h.h.s..p..s..s.p...l.h.L.p..p.s.t.lhlp..h...........................................	0	152	303	397
+3360	PF05209	MinC_N		Septum formation inhibitor MinC, N-terminal domain	Finn RD	anon	COG0850	Domain	In Escherichia coli Swiss:P06138 assembles into a Z ring at midcell while assembly at polar sites is prevented by the min system. MinC Swiss:P18196 a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with MinDE. MinC is an oligomer, probably a dimer [1]. The C terminal half of MinC is the most conserved and interacts with MinD.  The N terminal half is thought to interact with FtsZ.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.14	0.72	-4.24	8	1242	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	1231	5	255	716	30	102.50	34	43.57	CHANGED	hppssl.-LKuophslslLpLcss...slsclhptLucKIspuPsFFpcsPlllslucl....-slshpALcpshpppGlpslGl.....thtppc...l..hph.G.LslLocucsp	.........................hppssl.ELKGSo.FTLoVl+..L+cs...-..cs.lcptLp-...Kl.u...QAP.u...F.h.c.pAPVVls.lu..sL.........cs...s..l..s..a.sslpp...s...l...s...ssGL+llGVss....tstphcsp......h....tch...G.LPlLstupt.....................................	0	66	134	198
+3361	PF03776	MinE		Septum formation topological specificity factor MinE	Bateman A	anon	COG0851	Family	The E. coli minicell locus was shown to code for three gene products (MinC, MinD, and MinE) whose coordinate action is required for proper placement of the division septum. The minE gene codes for a topological specificity factor that, in wild-type cells, prevents the division inhibitor from acting at internal division sites while permitting it to block septation at polar sites [1].	25.00	25.00	29.00	25.50	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.37	0.72	-4.47	104	1852	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1808	14	433	931	152	69.60	41	75.76	CHANGED	SAslAKERLQlllAH-Rsthps...-....hLspL+cEIlpVIsKYVpl-p.-plplpl-.+s.psh......ssL-lNIslsc	......oAslAKERL.....QlIlA.c-Rsssts....sc.....YLspL+c-ILcVIsK..YV....p.IDs...-tlpVp.l-.+s....scl........olLElNlsLPc...................	0	129	267	356
+3362	PF00230	MIP		Major intrinsic protein	Finn RD, Delamarche C	anon	Prosite	Family	MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.68	0.70	-4.89	14	9641	2009-01-15 18:05:59	2003-04-07 12:59:11	15	26	3806	68	2727	7120	1558	211.20	28	85.40	CHANGED	Ehpphsh..hRAslAEFluThlFlFhuhG..ouluhsttst.........................s...........sllslAlAaGhulhshV.ssup..ISGuHlNPAVThuhhlupplollRAlhYhlAQhLGAlsusulL+hhpsu....................pssthss.lusGhssspuhshEllhTFhLVhslaussDch+ssp.up....APLuIGhhVshstLsuhPhTGsuMNPARSFGPAllttp..............assHWlaWlGPhlGAhluullY	................................................................................h..........tt.hhuEhlGT.....h..lh..l...hh.GsG........ssh....h...th.t..h.s..................................t.........................shh.hls..h........u.a..G.....h.u.....lh.....h..h..l.a....s...sut.....l...S...G..u..Hl..N.....P...A..........VTl................uh.......h........l.......t.........u.............p...........h.........s............h.............t......c...s......h.......Y......l...l...A...Q.hl.GAh.....h.....u.......u.s.l.l.h.h.hh.h..s.h...............................................................t.t..hs..h...h.....s....p..h....s..s......s......t......h....s...h..h..p....u......hh........s.Eh..lhT...hh...Ll.h.s...l.....h.........u.......h........s........s.....p....t............p..s.....s.....s.....................................h..s.s.l..s.....l...........G...h.h..l....hh...l....t.....h....s.....h.......s....s....hT......G......h.u.h.NPAR.s...h...G...P.t.lh.t..t.h........................................th..t......h.W.....l.....h...l.uP.l..l....G.u.hluuhha.....................................................	0	763	1487	2164
+3363	PF03094	Mlo		Mlo family	Mifsud W	anon	Pfam-B_2483 (release 6.4)	Family	A family of plant integral membrane proteins, first discovered in barley. Mutants lacking wild-type Mlo proteins show broad spectrum resistance to the powdery mildew fungus, and dysregulated cell death control, with spontaneous cell death in response to developmental or abiotic stimuli. Thus wild-type Mlo proteins are thought to be inhibitors of cell death whose deficiency lowers the threshold required to trigger the cascade of events that result in plant cell death. Mlo proteins are localised in the plasma membrane and possess seven transmembrane regions; thus the Mlo family is the only major higher plant family to possess 7 transmembrane domains. It has been suggested that Mlo proteins function as G-protein coupled receptors in plants [1]; however the molecular and biological functions of Mlo proteins remain to be fully determined.	18.50	18.50	18.50	18.50	18.10	18.30	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.66	0.70	-6.38	10	512	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	76	0	283	513	6	337.20	33	80.51	CHANGED	sstpoL-pTPTWAVAsVCsVllhISlllE+hLH+lG+ahK+++KKALaEALEKlKsELMLLGFISLLLTluQsh.IucICl.spclupsMhPCs........s.tcEcsshupph...........ssR+LLt..............shAssusspCucKG+VPLlShpuLHQLHIFIFVLAVFHVlYsllThsLG+hKI+sWK+WEcEstsh..-a-husDspRFRasH.......-TSFlRcHh.shWo+.oshhhWVtCFFRQFasSVsKoDYLTLRpGFIssHhss..ss+FNF+KYIpRSLEDDFKsVVGIS.hLWshsVLFLLlNlsGWcoYFWloFIPLlllLsVGTKLEtIIocLALEIpE++sVlcGsPVVpPSD-hFWFu+PcllLaLIHFlLFQNAFpIAaFFWIhasFGl+SCaHcphshllsRLllGVhlQlLCSYhTLPLYALVTQMGSpMK+ulF-EpsucAL+sW++ssKc+pchtt.......ppGusssssucssss......spuoSssplLppspspsss	............................................t.........sW.ls.hh.hhl.hshhh-h.lphhtp...........hh.pp.pp.p.h.tsl....+hpt.......ELMllGhlSLlLsh.hpt..l..plCl.s...t.h.......h.h.C.....................................................................................................................................C.......t......G......sh.hS.tulcpLH..hFlFhLAlh....HlhashhT..hhLuhh+.....h.pt.W+.WEtph.t............p.......................t........h.....h.p................p....pFhpt+h......t..h.p........hh........ah....hsFh+QFh.tSV.+sDYhshR.uFl.h......Hh...........pasFppYhhRuhEp-FchlV..Gl.........S........l..Whh.slh...hh...........hhs..hp.G.h............hhW.hsh......lPhhll.LhlGsKLphllhphu...........c..............ht...t.......t...t.....hh...........p............t...............hl....ps........pcphFWFt+PphlLhL.IphhLF..................Q.NuFphshFhW.h........h..p..hu..h...p....oChht.p..h...........h........h.+lh.hG.hhhQhlCSY.TLPLYAlVo.QMG.ophK..tlht.pphtpslhtWttt.s..+pp..t..............................................................tt.......................................................	1	53	194	244
+3364	PF03304	Mlp	Lipoprotein_12; 	Mlp lipoprotein family	Mifsud W, Bateman A	anon	Pfam-B_1663 (release 6.5)	Family	The Mlp (for Multicopy Lipoprotein) family of lipoproteins is found in Borrelia species [1]. This family were previously known as 2.9 lipoprotein genes [2]. These surface expressed genes may represent new candidate vaccinogens for Lyme disease [1]. Members of this family generally are downstream of four ORFs called A,B,C and D that are involved in hemolytic activity. 	21.00	21.00	21.40	21.00	20.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.21	0.71	-4.21	13	220	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	33	0	23	188	4	128.90	36	65.43	CHANGED	sQQTKSRpKRDLoQcEhsQQ.K.p.p..EEhLhppLs..................cspKo........ahDWLp........Ehhsuhuch.cFLEsc...cuKhKoh.saIKutlDspsup...............spsNcttsshpsslppaF+GsshDhF....uNptlhpCh	..................................pQsKSRtKRDLo...QcE........sQp.K.p.p..EEhlhppLs.......................cspKs..................ahDWL+............-hlsuhsch.pFLcpc..........cuKhKshhsaIKutlDpsss....................ppssp.tss.h.pp.lpthh.pGs..h.D.F....sspt..t................................................................................	0	9	9	9
+3365	PF03562	MltA		MltA specific insert domain	Bateman A	anon	Pfam-B_1127 (release 7.0)	Domain	This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme [1]. This domain may be involved in peptidoglycan binding.	25.00	25.00	28.10	27.70	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.85	0.71	-4.50	47	1797	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	1393	13	305	1164	129	152.30	46	39.97	CHANGED	llcuStspsspapaPlYphPssh....................................................................tp.thhsa.sRtpIp......tsult.puhpluascs.lDhFhlplQGSGplphsD....Gphlp.luYAupNGaPYpuIG+h..............Ll-cG..................clstcphShpuI+pWhptp.Pp.clpclLppNsSaVFF+	...............................................VlpuccpRpupapaPlYthPsc..........................................................................t.tht.h.o.Rsp.I.........uG.A..L.s...cu.hlLuYups.lDsFhMclQGSGhlch..s..D....G..p..h..l..p.huYAuKNGHsYpSIG+h..............LlD+G...................l...c....tp....p...hSMQu..I+pWhcp..p....Pp.cl....pE....LLppNPSaVFF+................................	0	69	167	238
+3366	PF01642	MM_CoA_mutase		Methylmalonyl-CoA mutase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1611 (release 4.1)	Family	The enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA [1].	19.00	19.00	19.20	19.00	18.00	18.90	hmmbuild  -o /dev/null HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.56	0.70	-6.36	11	3025	2009-01-15 18:05:59	2003-04-07 12:59:11	17	11	1507	35	1053	2608	2315	449.20	38	72.72	CHANGED	apTsEGIslcPlYt..ccchp-hpt..htshPGhhPFsRGsYsTMYshpPWTIRQYAGFuTsc-oNthY+hslAsGQpGLSVAFDLATppGYDSDsPRlhG-VGpAGVAIDol.DMchLFcGIsLsphS....VSMThNGsllPlLuhYlssuEcQGVp.ppLsGTlQNDILKEahsRsTYIaPPcPShRlIuDIhtasuccMP+aNoISISGYHhpEAGAoAs.ElAaTLADGlpYl+sulsuGLslDsFAPRLSFFauIGhNaFMEIAKhRAARhLWA+llcp.Fu..sKssKShhLRsHuQTSGWSLTtQDPaNNllRTslEAhAAslGGTQSLHTNuFDEAL..uLP...T-FSARIARNTQlllpEEStls+VlDPhGGSYYlEpLTcclsccAhphIpcI-EhG................GMs+AlcsGlsphcIpEuAA+cQscIDpGcpslVGVNKYpl.cEttl-..lL..cl-sssVctcQlc+LpchRusRDsctlctAL-tlscsAt......tst...NLLsLulcAuRspsTlGEho-Ahccsasca	.....................................................................................................................................................pt..ht.ha..........t..t.........t....t...h.....................h.sh..sG..PahRG..sh...s..s.h.h..h....sp...sW...s.....hRQaAGauoA.c.-.oN.tha..+.h.t..l.s..t..G...p.p.....G..L......S..s......A.FD..h.sTh.hG.hD.sD.p.s.p...l....h....G...-V....G.t...s.GV...ul.s.ol....DMc..hLFc....sI.sL..s..p..h..o....lS..M..Th.N...u.s...sh...s....l..l.A.hal.ss....u.........c..-..Q...............G.............s..s................................p......................p......................lpG..Tl..Q..s..D..I..LK................E....ahs+...sT.aI.a.....P.P..p..s......S.h..+.l..l.....u..D.lh.t.a.s.u.p.p..h..P..+a...s..o..ISI.SGYHhpEAGAssspElAaTLAsGhpYlcshl........p..t....G....l....s..l....D....p....F...A...s....+L..S.F..F.auhuhs.h.FhplAKh.RAARhLWuclhct.as.............sps......s.+..............u.h....h..LR.....hH..sQTSGhoLTtQ-PhsNllRoslpAhuAsh...G...s...spSLH.T.Nu.hDEA.l........u.LP.......o-hSsRIAhsTQllltpE.otlsc..shDPhuGSaalEpLTppltcpAhthhpcl-p.h...G.................................GhstAl...csGh.phpIp-uutcpptpl-p..Gc....p....sllGVN.ca...................t...p.....-.....p.........h....-...............l.l...........pl..-.........s.............s.....h............p......t..p.......Q..l.....t..........pLp..p.h..+.....t.....p...R.....c.....p.....t.....t.............sp.............t...sLt....tl....p..ps....At.................................tt........Nlh.thhhpAs+s..h.solGEhstshptshst..................................................................................	0	382	755	937
+3367	PF03972	MmgE_PrpD		MmgE/PrpD family	Bateman A	anon	COG2079	Family	This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle.	28.20	28.20	28.70	28.80	26.30	28.10	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.25	0.70	-6.31	16	2262	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	1523	6	768	1930	3171	437.30	28	94.04	CHANGED	ppshcclAcaltshphosh....psh-ps+htllDslGsuhsuhpp.sspthhs.hs.sshsps.ssplhsTptphssstAAhsNGshs+hLDasDsahuAchttsSsslPulLAsA-tluts...........h..c-lLpAhlhuYEItsplAtptuhpchs...hspshalslAuAAusucllsL-p-plhpAluhAhspusulRphcputhsup+t..usu.AstsGlhuAhhAtpGhsG..Psslh-sphGFhcshhss.shphp.................atlpsshhK..aPsphHupoAs-AAhpL+cchp.....hpcIcplplcTapsAh+llscss.......sPpshcsscaSl.YhlAlsLlhGphslppacsch.hpDscl.sLtc+lphp.sscasptY....Pppps....splhhccsssht-ttl-hPhGc.hcpshuhsplh-KFcplhtthhs..pppp.hhhttshcptpltshhss	...............................................................t...h.plsc.al.hshp.hss.h......shcpA+htllDsl..Gsul..t.u.h...p..h..s.......s.s.p.phhs....h......s................u.....t.....s.......s......s..............s.......u............sp.V....G..........s..........s...........h.....p.l.....sP..s...tAAas.Gshh+hLD.......a......sD.T..........a.h....u...A...c........ht.t..su.........s..........sls......u....lLA..sA.-h.l.ups...................h...+clLpAhltuaE..lpsp..l.....u.........h....t.........s......u..hs..+hs.............hs.p....s.h..h.s...p.....l.....u.....usA.ssuch......LG......Ls..p-p......l.hsAluh....A..h.s..p...u...t...u.....L......+...p...h...p...c..us....s.sup+t..hssGpAsppulph.......Ahh.A.p.p.G...h.G.....P..s..slh.t...s.t......h...G....Fh.cs...h.h...p...s...p...s.h.cht...pshu...................................pas.h....p..s..l..h.a..Kh.aP........upaaupsAl-AA.h...pL..tpp..httt............ss-I.cclsl...c......T...pc..s.sh.cl...l..s....c.ts............s.ssst.-..t.ca.sltYhlA..lsL.l...h...G.c...l..s..h...........s.c.apc...........sh...h.....p...c....s........clps.LtpKlps.h.p.D...s..p..hots.Y..........Ppc.psh................ltl.th.p....c..G.s.....p.h...p..hhlch..s.hG....p...hccs......uhsplh.pKFpt.ths...th.hs....ptp...hhh....t.....................................................................................	0	185	425	615
+3368	PF02406	MmoB_DmpM		MmoB/DmpM family 	Bashton M, Bateman A	anon	Pfam-B_1148 (release 5.2)	Domain	This family consists of monooxygenase components such as MmoB methane monooxygenase (EC:1.14.13.25) regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen [1]. Also found in this family is DmpM or Phenol hydroxylase (EC:1.14.13.7) protein component P2, this protein lacks redox co-factors and is required for optimal turnover of Phenol hydroxylase [3].	25.00	25.00	25.90	43.80	24.10	19.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.48	0.72	-4.00	40	224	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	168	27	81	207	3	87.60	31	82.55	CHANGED	sspVslslp..ss--scsllEAlttD......NPs..stVp-psuhl+IcucGcLplc+polpEtL.GRsaclp.-lplslsohuG+lpps.D-phslpa	..............stVslslp..ss-pucsllEultp-......NPs...ssVpcpsuhl+I-up.ucLhlctpslpEtL.G+s...achp.plclshsohsG+lspp.DDphhlh...........	0	29	57	73
+3369	PF03176	MMPL		MMPL family	Mifsud W	anon	Pfam-B_357 (release 6.5)	Family	Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.92	0.70	-5.73	34	10072	2012-10-02 18:57:54	2003-04-07 12:59:11	10	47	2346	0	3112	23929	8914	311.20	16	68.96	CHANGED	shsspsusuhtshcphsphF.p..ssssshhhlhh.tsstsLss.sspsshpphlsplppDsstlspl.D.......................hs.......................ss.....stthhhSsDG+Ashh.lshpGs.usstu.pslsslcshscpss...s.pGhpshlsGsAuhhtDhpcusstshtllthsslsllhllLlllaRSllssllhlhTVslSlssuhGl.lhlhtthhslslsshslsl.hshlhlAsGoDYslhLluRa+EthttG.cptt....uhhpAhtuoGpVlsuuGLslAhshhu...LshucLshhsp.lGsslulGlllssLsshTlh.PAlhsl...........hGRh...............s.t....................thW..phuthls+tPtsh	............................................................................................................................................................................................................................................................................................t.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..s.............-.......t.....p.....h....h.............h..h..........l...........h............p...............t..............t......s.......t.....t.......s........p.......t.......h..........p.........t....l.....p....p.....h...h.p.ph...........................ts.h.....p..s...h...l....s....G.........s..s...h...t.....t....-......h..t...p.........t...h...p.......p.......s...h..h....h.h......h......h..l...s...l.s.l......l...h....l...l....L..h......l..s......a.....R....S......l....h.....s.......s.....l....l....s....l......l...s.....s.........h......l....u.....l.........h..........s.........s........h.........Gl.......h.....h.........h..........h............t.........h.........h.............h..........h...........h...............s...............l..........s.........s..........h.........s...................s.........l......s........h....s......l....h..l....u....l.....u....h......D..Y..sl......a....l.....l.....s........R....h.........+...E.......p..............h.....t........p..........s.......t..........s......t..........p........................A....l...h.....p......u....h....t......s......s....G......p....s....l....h........h...u........u....l....s...h....s....s.u....h...h..u...............h......h.......h............s...............s...........h.........s......h.......l..............p...p......hG..h...........s.h...u....l.......u.l....l....h....s..h....h....s.s..h.s....ll...P....A....l..h.t..l..................................h..uph...............................................................................................................................................hh...........................................................................................................................	2	1002	2163	2770
+3370	PF01926	MMR_HSR1		50S ribosome-binding GTPase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.14	0.71	-4.13	703	46032	2012-10-05 12:31:08	2003-04-07 12:59:11	18	181	5181	76	12638	71407	21684	130.90	24	37.52	CHANGED	plullGhPNsGKSoLlN..tL...............s..............t...t.....p..........hsh..................................lush..s...us..Tpch.hh.......thh.h..........................................tt.................h....h.llDosG..................................lh............pt...tp.h.........................t.........hhpt........h..hptl.pps...........-l...llh.......ll.......D.sp................h.......t................t...pl......................h.....................ppl............................................................tt.shlllhNK	.....................................................................lullG..h.PNVGKST..LlN..tl..........................................s.......................s....p.c..............hsh............................................................................................................................................s..u.....s..h.......s.......t..s....T...pc.......h..................th..h.ph.................................................................................................................................ss.t.p....................h...........h.llD..T..s....G.............................................................lh................cstt.ps.t...................................t....hhp..p........................h....hp....t...l....pps.................................cl...........llh........................ll.....-...hpp...............t.............................tt.....l.....h.....t.h...........................................ths.h.hhhhsK..........................................................................................................................................................................................................................................................	0	4467	8137	10741
+3371	PF01054	MMTV_SAg		Mouse mammary tumour virus superantigen	Finn RD, Bateman A	anon	Pfam-B_518 (release 3.0)	Family	The mouse mammary tumour virus (MMTV) is a milk-transmitted type B retrovirus.  The  superantigen (SAg) is encoded by the long  terminal repeat. The SAgs are also called PR73.	21.60	21.60	27.40	27.40	21.40	19.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-11.90	0.70	-5.53	5	88	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	18	0	0	93	0	231.20	73	95.85	CHANGED	MPRLQQKWLNSRECPTLRGEAAKGLFPTKDDPSAHTRMSPSDKDILILCCKLGIALLCLGLLGEVAVRARRALTLDSFNSSSVQDYNLNNSENSTFLLGQGPQPTSSYKPHRlCPSEIEIRMLAKNYIFTNKTNPIGRLLITMLRNESLPFSTIFTQIQRLEMGIENRKRRSTSVEEQVQGLRASGLEVKRGKRSALVKIGDRWWQPGTYRGPYIYRPTDAPLPYTGRYDLNFDRWVTVNGYKVLYRSLPFRERLARARPPWCVLTQEEKDDMKQQVHDYIYLGTGls.lWt.hFaYT+EGAlA+lLEshKAssh	................................................................GLFPTpDDPSAppRMSPSDKDIhILCCKLGIALLCLGLLGEVAVRARRALTlDShN.sSSVQDYNLNsSENSTFLLtQGPQPTSSYKPHRhsPSEIEIRMLAKNYIFTNcTNPIGRLLlhMLRNESLsFSTIFTQIQ+LEMGIENRKRRS.TuVcEQVQtL.AoGLEVKcGK+SshVKIGDRWWQP..GTYR...GPYIYRPTDAPLPYTGRYDLNFDRWVTVNGYKVLYRSLPFRERLARARPPWCVLoQEEKDDMKQQVHDYIYLGTGM..ahthFa.o+EtAht+ll-phpt...............................	0	0	0	0
+3372	PF05067	Mn_catalase		Manganese containing catalase	Bateman A	anon	COG3546	Family	Catalases are important antioxidant metalloenzymes that catalyse disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese [2].	20.80	20.80	20.80	20.80	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.71	0.70	-5.65	6	1280	2012-10-01 21:25:29	2003-04-07 12:59:11	7	5	890	24	300	1030	18	231.50	36	96.59	CHANGED	MF.hHsKcLQY.sKPs+PDPshAKtLQElLGGpFGElSsAhpYLaQGaNpRscsKh+...DLLhDluTEEluHVEMlATMIu+Ll-sAssctpEcAsc.s.hhtulhuGhNspH..uIloGhGuhstsSsGsPWoAsYIluSGNLlADhRtNlsAEupuRlphtRLa-MTDDPGl+DMLoFLlsR-thHQ.pahtAlcpLctp-.s.hlPss........as+thEcQEhu+phhNhScG-.sopupWhpGcu.-thtthphlhtshshuthPcL...............+sAP.h.+sT.......lsspthh	.........................Ma.hap.K.c.L..p.a..s.V.+.l.spPsPthA..phL.EQhG.GspGELuAAhpYhsQu.hsh..p...s.t...t..t......+...-lLhD...IuTEEluHlEhluohlthL..hcs..u...ss.p........h.........c....s....s.......t............................................................................................sp...H...........hl.......tutush.ssusGsP...WoAsYlp..s..pG-.huDLhpNlAAEt+A+hhYppLhph.o.DD.ssl+-sLpFLhsREhsHpppFtcALpplpsph...............................................................................................................................................................................................ttt.........................................................................................	1	112	214	248
+3373	PF03962	Mnd1		Mnd1 family	Wood V, Bateman A	anon	Wood V	Family	This family of proteins includes  MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair [1].	29.90	29.90	29.90	30.10	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.63	36	274	2012-10-04 14:01:12	2003-04-07 12:59:11	10	2	237	0	195	289	2	181.60	31	82.42	CHANGED	lhchFhpopshasLK-LEKhsPK.p.GIsshpVK-llQsLlD.-slVpsEKIGouNaYWsFPupshp..........................ptcsphpcLppclpchcpchpplppplppt.ctsRcps.............p-Rpp.lhpclppLpcchcpLpsclp..phppsDPptlcch+ppsphhtpusspWTDNIas..lpsahpp..phshpppplc...pphuIs.p-h-Y	..........................................hhphFhpopshapLK-LEKhsPK.p.GIs.u.hsVK-llQuLVD...D...shVcsEKIGooNaYWuFPucthp....................................................................tpcpphcpLppplpchppchtpLppplppt.....ct....sR.p-o................cERpp..hhpclppLcp...chppLc...s-lp.......phpc..s......D.P.p.hlcphcp.thpht+cuss+W.TDNIas..l.pp..ahpp..p..h.shppptlc...cthtls.t-hc.................................................	0	82	114	162
+3374	PF04039	MnhB		Domain related to MnhB subunit of Na+/H+ antiporter	Kerrison ND, Finn RD	anon	COG2111	Family	Possible subunit of Na+/H+ antiporter [1], [2]. Predicted integral membrane protein, usually four transmembrane regions in this domain.  Often found in bacterial NADH dehydrogenase subunit.	21.80	21.80	22.10	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.69	0.71	-4.06	25	1811	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	1346	0	552	1386	262	127.40	30	27.60	CHANGED	shIlcsss+hlsshllhauhhlhltG..H.sPGGGF.uGlhhAsuhlLhhluhuhp....phhphphttlhslG..lhhshlssls.hhhGhshhs.......h.hshhu...........pshlhsshhhslGlhlssstsshhhh	...............hllpsss+llhsllllhuhalhhpG..HssPGGGFluGLlhusA...hlLhhlA.h.shc..h............h...............pp........h...h.................h......s...............ht.h.lh.ulG.......ll..h......ush.o...ul.s.u.hh...h.G..t....s.FLop.............hhhplPhlu....................phcl.soshhFDlGVhlsVlGsshhh...................................................................................	0	158	340	458
+3375	PF01899	MNHE	DUF68; 	Na+/H+ ion antiporter subunit	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Subunit of a Na+/H+ Prokaryotic antiporter complex ([1],[2]).	21.80	21.80	21.80	21.90	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.97	0.71	-4.59	164	1796	2009-09-11 05:06:25	2003-04-07 12:59:11	11	2	1345	0	544	1267	256	146.80	25	89.96	CHANGED	hslhLhllWlhLs........s...........sp.........llhGhllullls.hhh.....pt.h.h...h.....................h........tllth..lhhh.lh-llhuslpVAthl.Lp.spht....p.Puhlplslclcsch.slslLAshIoLTPGTlsl-l...........sp-p.....ph..LhlHslc......hsst.tt....hhppl..ppphEchlh............cl.a	..........................slhlhhhWlhls.........s...p.hs..hss.........hlhGh.llulhlh....hhh.......pt.h.hst..p................................hhhphh.....thlph.lh.hhlh-l....lpuslp.Vsph.l.......lp..sphp...hc..P......u.hlt.h...h.c.lc.s-h.slslL.ushI.TLTPGTlslcl.................................sp..-..p.....ph.lhlHsl-...hsst...cp............htpl...ppphEchlhcl.......................................	0	161	337	456
+3376	PF03404	Mo-co_dimer		Mo-co oxidoreductase dimerisation domain	Bateman A	anon	Bateman A	Domain	This domain is found in molybdopterin cofactor (Mo-co) oxidoreductases.  It is involved in dimer formation, and has an Ig-fold structure [1].	20.90	20.90	20.90	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.91	0.71	-4.52	25	2673	2012-10-03 16:25:20	2003-04-07 12:59:11	11	47	1355	31	742	2393	488	104.90	33	28.91	CHANGED	cauIh-Lsl..NSsIspPpHsEhlslss.......tsYsl+GYAYuGGGR+IsRVEVoLDcGcoWpLAslcatEc..+.....tc.............tpaCWsaWsL-lsls-...Lhssc-IhlRAhD-uhslQPc..chhWslhGMMNNsWaRVsIphp	............................................phsh..pShls.P.t..t..t.p..l..hs.....................t.hplpGh....Aa..sGs..u..t.lt+V-...lo...hD....t....Gt.sWp.u...p...l..t.....t.............................................asWphW..php..l...p.l.s...................ust.....c...l..hsRAhDcshssQPc....p.hWNhh......s.............t........................................................	0	208	443	625
+3378	PF01967	MoaC		MoaC family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.	20.70	20.70	24.50	24.30	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.79	0.71	-4.50	19	3524	2009-01-15 18:05:59	2003-04-07 12:59:11	16	27	3330	47	977	2349	1242	135.10	51	71.35	CHANGED	MVDlopKssopRpAhApuhlphpscslchIppsplt..KGDVlusApIAGIhAAK+Tu-LIPLCHP.LsLouVcV-........hchp.ct..lclpusV+spG+TGVEMEALTuVSVAsLTlYDMsKAl-+s.......hhIpsl+LlEKoGG	...........................MVDVSsKstThRpAhApuhlph.p.s.c.s.l.p.h..I.........t...s............u.....p...hp...................KG.DVlusARIAGIhAAK+Ts-LIP.L.CHP.LhLopV-Vs...................................hp..h..p....s....p...p.......t....lcIpups..+ss..G.+.T..GVEMEALTAsSV................AALTIYDMsKA.V....-..Ks.................MhIssl+LlpKoGG.....................	0	325	623	829
+3379	PF02391	MoaE	MoeA; MoeE;	MoaE protein	Bashton M, Bateman A	anon	Pfam-B_1056 (release 5.2)	Family	This family contains the MoaE protein that is involved in biosynthesis of molybdopterin [1]. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.	21.40	21.40	21.70	21.50	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.42	0.71	-4.29	18	3376	2009-09-10 22:57:28	2003-04-07 12:59:11	12	13	3008	21	906	2269	1201	115.20	35	72.11	CHANGED	cltlsspP..lsssthhphlsssps..GAIVsFsGhVR-hstG+.pVppLpYEuYs.MAtcpLppIspEsc.........p+asshc.ltlhHRlGhLplGEssllluVuusHRp-AacAscahlDplKpcl	........................................................t...lt.ps..hs..h..s.p.....h.p.h..l..t..p...ppp......G.A.llsF....sG..pV.R..s.t.........s............t.....G............c......pl...ps......L......p.....h..E.t.Ys.s.M..s..c+t..LtcI..sp-sp............................p..+...W..s...l.tp....lsl.hH.RlG.pLtsG-thVhluVoosHRpsA.FcAspalhDhlKsp.s.............................	0	273	561	756
+3380	PF01076	Mob_Pre		Plasmid recombination enzyme	Finn RD, Bateman A	anon	Pfam-B_717 (release 3.0)	Family	With some plasmids, recombination can occur in a site specific  manner that is independent of RecA.  In such cases, the  recombination event requires another protein called Pre. Pre is a plasmid recombination enzyme.  This protein is  also known as Mob (conjugative mobilisation).	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.25	0.71	-4.67	18	1003	2012-10-02 18:54:05	2003-04-07 12:59:11	14	11	568	0	72	798	47	164.00	24	46.75	CHANGED	Mu.aulhRhpKhK.ssslsGhppHspRpppsp...pNcDIDh-+othNh-Lhss.pshsappcIcphlpcph.tp.RtlRpDAVlhsEhllTuss-Fa.csho.E-p+caF-puhcahpccYGc.pNllhAslHhDEs...........TPHMHhG.......lVPhs-ct.....+LSAKclhst+cpLpphQs....chschhpppGapLcRGptt...oc+KHhssspYKp	......................................................................h...Khp........tsht.ht.H....pR.....pp.............sl..pctt.N...hc.h..h.....p............t.....p......h..p............p..t..l.p.phlpp....h.....................pth+.pcs.h.hh..........chll.o...s..s..c....hh.......p........t..........h........s..................p..c..............t.........cpah....p...p........shp...hh....p.c...+..h.....Gp..pNlh.AslHhDEp....................TPHhHhs.......................hVPh..spst.........................+ls.u+plhs......c......p.....p......Lt......thps...................ph.phht..p....h..lp.R.G.......ott..cp...h..ah............................................................................................	0	20	46	62
+3381	PF03389	MobA_MobL		MobA/MobL family	Mifsud W	anon	Pfam-B_3424 (release 6.6)	Family	This family includes of the MobA protein from the E. coli plasmid RSF1010, and the MobL protein from the Thiobacillus ferrooxidans plasmid PTF1. These sequences are mobilisation proteins, which are essential for specific plasmid transfer.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.53	0.70	-4.93	9	1275	2012-10-02 18:54:05	2003-04-07 12:59:11	10	14	701	1	159	1186	123	200.30	31	35.78	CHANGED	RSAssuAAYppss+h..E+ps+shDYsp+p.lhapEhlL.PspuPp.h....sDR......pshWNcVEshE+RssupLs+-lplALPhELTs-pphtLlc-FlcchhsscGMlADhslHt.........................Dss.tNPHsHlMhThR.lstDGhhtpK.....hhlstsGp.h...........hsttGc.......lhhp.W.sspshhsphRcsWt-phNptLpttGlshRIDtRSacpQGI-hhPTlHlGssu+thE++	..................................................................SslusuAY..huspplhs........-....h...u...........hh..c.as..p+p....lhh.pphhL..Pt..p...sP..t...h................t-R..........................ppL..WNt.....V.....E..t.h...E...+.........p....psu..pl..ARch.lAL.P..p..E..L.......s.pp.p...........hpLlpcaspc.p...h..s..s..p..GMhsDh.AlHp........................................................sss....t....NP..........HsHlhhohRs...l..s....cGh.h.ttc.............h..tptst.....................................................................ttt.............................psW....sspp...thp.taRcpWushsNphLtpt.s..h.......pt.....R.........lDcRSh.......pp.Q..............u.......h....c........PphH.G.tsttht......................................................................................................................	0	30	90	120
+3382	PF03205	MobB		Molybdopterin guanine dinucleotide synthesis protein B	Mifsud W	anon	Pfam-B_2446 (release 6.5)	Family	This protein contains a P-loop.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.92	0.71	-4.47	28	2671	2012-10-05 12:31:08	2003-04-07 12:59:11	9	40	2297	9	887	3759	1045	131.50	27	46.35	CHANGED	shlhlVGspDoGKoTLhctLlshhhppGh+sshhhchch.Gp.slshPGs..............luhs.hcc...h.h.pth..ppphs...............llhh.Gaps.sspsc...lslsp...phsphhppph..........................pt.shllso	...........llsls.G..h.s.soGKTTLlcpL.l...s..t......L.......p.........t...c.........G....h.....+....l...u...h....l..KH.sc.H......p.....h...-...........l..D...h.......s..Gp....Do..h....ch...tpA.G...A...t.t..s.l.l.s..upp...............ht.h..h....p.p.....h..............p...p...p.s.....L..t....lhtths..................hD..llLl..E..GaKp.t...shsK.....l.lh.R......t...........................................hhh.hhh.t..............................................................................................................	0	285	523	732
+3383	PF04698	Rab_eff_C	MOBP; MOBP_C-Myrip;	Rab effector MyRIP/melanophilin C-terminus	Waterfield DO, Finn RD, Eberhardt R	anon	Pfam-B_4174 (release 7.5)	Domain	This domain is found at the C-terminus of the Rab effector proteins MyRIP and melanophilin.	20.80	20.80	22.10	20.80	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	714	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-13.27	0.70	-6.42	7	193	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	47	0	70	165	0	315.90	37	56.40	CHANGED	ChDlltGuhhEsslENEGSIsGSDSTFYRQSE.GHSMMDTLAVALRVAEEAlEEAISKAEuau.DSLDKQNEAsYLR-HKEELhEELATTIlQKIIRKQKsKoEQt..Et-s-WPpsp....ssSspsuDpuhhshPGucRusssLWRSQSAFSlsuEDs......htoussEuhh+p.+spsp+.+-c..SALPSWKSVDpLs-oshsPVLpSsDGNWVALpsso.hPPs..RhLAKPKSpsFpALEstSpVsSAYDEhGS-SEEDaDWu.ALscLp.pspth......tps..pst.s.us-ph..ssSPSsuh.sNsEshh.SDSETSShsSSpEu+.tpu+..WlpR+sspN.sptEKh+lpGEL..DVNFNPQusuhEhSDSSEsEEs.ash-++uRRW+Rs+stsEE.s.t.spscuph+sLpTpps.t...DLSETDlSsEspcp+o.sDshEEKL+oRLaELAhKMS-KETSSGE-QESEsRTEs-NQKpuLSSE-supsVQEELKKKYSAVSLCNISTEVLKVINATEELIAESoGPW-hPssstD+tcGoFPlGTD.lRLDEQLToLEENVYLsAGTVYGLEGQLoELEDAARpIpSsTsEoELA-LEDQVATAAAQVHHAELQISDIESRISALTlAGLNlAPCV+LTR+R-QKQpsQVQTIDTSRQQRRKLPAPPV..KuEchEuSsVTslKTFNRNFlLQGShTpRsK.ERKSosKDLMEPsltSAlMY	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................st.Ts-pELu-LEDpVAssAupVppuE.plSDIESRIuALphAGLslts..sc.p+..+pp....................................................................................................................................................................................................................	1	2	8	33
+3384	PF05161	MOFRL		MOFRL family	Bateman A	anon	Guo J	Family	MOFRL(multi-organism fragment with rich Leucine) family exists in bacteria and eukaryotes. The function of this domain is not clear, although it  exists in some putative enzymes such as reductases and kinases.	20.20	20.20	20.20	21.40	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.38	0.72	-3.92	14	869	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	746	3	399	837	348	107.80	45	25.09	CHANGED	PssLlsGGETTVslpG..p.G+GGRNpEhsLuhshtlc....st.sh...hhLuusTDGIDG....soDAAGullsssshtp.hpstGlD..tphLpssDSYshapthus...LlhTG.TGTNVND	..............................PsslLuGGETTVT.l..p..G................p....G.......+GGRNpEhh..LuhA....hslp.......................Gh.s...s.l...........hsLuusTDGlDG.........spDsAGAh.ssssols+...hp..t...tG...........l....c.....stshLssNDuashFpsl.us............Llh.T.GPTtTNVND................................	0	127	238	325
+3385	PF04603	Mog1		Ran-interacting Mog1 protein	Waterfield DI, Finn RD	anon	Pfam-B_4771 (release 7.5)	Domain	Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homologue of Mog1 is thought to be alternatively spliced [1,2,3,4].  	19.80	19.80	20.80	21.90	18.00	19.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.86	0.71	-4.24	3	266	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	230	2	185	261	3	130.10	31	62.57	CHANGED	ssPLFGGALSAILPPthlDVS-LRpIPDNQEVFsHsSTDQ.SlIVELLEhQE+VpDuuAARYHFEDVAusNDAcu.scVhSVcPLuL-sL.uLRu-CssAWlLoGpQpV...AKcNpEuAssVsIHhALlRLPQaQTDLLlTFNsPs	.................................p.h.LaGGAls.s.slPt....sahDlS....sl.RpVPDsQEVFs............s...s............s...........s.............c...........p...S..........lIlEl...................LEhh......s...................p.......s..........ps..t....p..A....hpaahpD...lu.t.p...s......s..ts..........hpl.....p....t................h..............t.p.h............t.............................................t................s........h..h.h...u.tp..p.h......................s+....t...p...p...........t..p......l.hl.hh..s..llR.L..p.....hpT.......Dlllohs.P.h........................................................................................................................................	2	59	103	150
+3386	PF04879	Molybdop_Fe4S4		Molybdopterin oxidoreductase Fe4S4 domain	Bateman A	anon	Bateman A	Domain	This domain is found in formate dehydrogenase H for which the structure is known. The first domain (residues 1 to 60, 448 to 476, and 499 to 540), comprising two small antiparallel sheets and four helices, coordinates the Fe4S4 cluster just below the protein surface [1].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.96	0.72	-4.15	65	10650	2009-01-15 18:05:59	2003-04-07 12:59:11	11	141	2936	51	2519	7754	1735	56.60	28	7.53	CHANGED	hchsposCs.aCGsGCulplts.......pssclh............plpustppPsNp.....GplCsKGttshph.lts	................phshosCs..hC..u.....s..G..Cu.lphts.................cssc..lh.........................pl..cu...c..s...s....s..s....s..sp............................GthCsKG.tthhchl....................................	0	756	1595	2106
+3387	PF00384	Molybdopterin	molybdopterin; 	Molybdopterin oxidoreductase	Finn RD, Griffiths-Jones SR, Bateman A	anon	Prosite & Pfam-B_2803 (Release 7.5)	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.38	0.70	-5.74	32	25621	2009-09-12 07:55:41	2003-04-07 12:59:11	17	170	4023	138	4565	20492	6386	349.30	16	53.56	CHANGED	RLppPhlR.....................................p.pGcahtloWc-ALshlsptlpp..tphsp....h...sssushsssEshhshpchhpthsut.hth.sthsch.............sss.ptshhhssslt...............sl-suDh..llLhGsNstpptsll......ss+hhpthhpst.....hclsslusphs......hshshcaluh..ssso.hsl.hshtpshhpphpt..sc.....................................................................................................................................................................................................................pshlllGt..Ghhpp.....tcGsshhttltslsthhs.ht....sasshs........................................................................................hlpstAspsush....................................................clsh.ss.thh...t..t....phhalhG...........................sDtsph..t......ph....chhllhpsph.spsAphADllLPussasE....+puhasNsEGpsQt....tppsl.ssG-A+pDWcIl+sLuch	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................Rlt.Ph..hp.....................................................t....s...t....h....h.sWppAhp.h......ttt......h.........t..........................................t...............................s...................t........h..................................h............................h.........................................t............h............h...t...................h......h..t.....h..h.h......t................................h........t........s..p..........t.............................................................s..........................................p.h....t.....p.s..ph.....h.....hhh.G....t.......N......h..t...s..t..............................h..h..h.......t.hh.tt............................hphlsl.s...s.hhpt............................ht....t.s.........a....h..........p.s.s.Dh.sh...h........u..h......h............h.h..........h..........p..........p.................h.................st..........................................................................h.........t.............h...................h...........................................................................................................................................................................................................................................................ht.......t..t..h...........t........h........t....h....s........t............h....................t...........................t...............................................h.........h.........s.h..............u..pp..............................u.........................h......h...h....h.......hG..p...h........s..........G...s.......s.....................................................................................................................................................................h....t.......t.............h..h..............................h..............................................................................................................................................................t..........................................................h.......h..............................................................................h..t...h...........h......h.h.t.................................................................s...............t.............p....t.h.h........t.h.t.........ph........c...h.h...l.s....-........h.......h...s......t............s.............s..................h............u........D...............l..........l............L.P.s.s.....hE...................p..........t.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1319	2784	3767
+3388	PF01568	Molydop_binding		Molydopterin dinucleotide binding domain	Bashton M, Bateman A	anon	Pfam-B_129 (release 4.0)	Domain	This domain is found in various molybdopterin - containing  oxidoreductases and tungsten formylmethanofuran dehydrogenase  subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase  subunit (FmdD); where the domain constitutes almost the entire subunit. The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a  molybdopterin dinucleotide cofactor [1]. This domain corresponds to the C-terminal domain IV in dimethyl sulfoxide (DMSO)reductase which interacts with the 2-amino pyrimidone ring of both  molybdopterin guanine dinucleotide molecules [2].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.25	0.72	-4.24	87	16734	2012-10-02 17:45:13	2003-04-07 12:59:11	16	106	3319	124	3570	12374	2211	112.40	22	13.29	CHANGED	lhL.hosR.shtphpoth.tstps.thtphts......hl.lsPpDApphG.lpcGDhVclpoppG....phhstA..tlocp.lt.Gslhhshtaht.................sssNhLT..ssthcPhuttPth.+ss.s	.......................................h.l.hos.+..ht.p.h..H..oth..t......s.hp.h..h.p.h.tp.hts.................hlhls.....Pp..DApp..h..G.........lp.....s...........G...D...h....V.............cl....h.....s.......p..p.....G...............pl..t..s.tA........hl..o.p......c.....l........h........s............G........s........l........h........h.....hshhh...................................tsthNsLT...t.thsshsthst.p...............................................................................	0	995	2156	2944
+3390	PF04744	Monooxygenase_B		Monooxygenase subunit B protein	Waterfield DI, Finn RD	anon	Pfam-B_6020 (release 7.5)	Family	Family of membrane associated monooxygenases (EC 1.13.12.-) which utilise O(2) to oxidise their substrate.  Family members include both ammonia and methane monooxygenases involved in the oxidation of their respective substrates.  These enzymes are multi-subunit  complexes.  This family represents the B subunit of the enzyme; the A subunit is thought to contain the active site. [1,2]. 	22.70	22.70	23.10	24.50	19.20	22.60	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.30	0.70	-5.76	5	143	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	76	12	16	144	19	231.40	40	82.99	CHANGED	GEKSQpAFLRMRTIpWYDlKWSK-olKVNEossIoGKFHVFEsWPcAVupPcsSFLNVGpPGPVFVRLooaINGphsPRSlsLEIG+DY-FEVsLKARRPGcWHVHTMlNVcGGGPIIGPGpWIsITGSMuDFcNPVTLLTGpTVDLETaNhuNsIFWHlhWhulGlAWIGYWstRPMFLPRhhhlpAGcDD-LlsspDKKVuhlVLluTLLlVlhGY+sTEoKaPhTIPLQAGppKslpPLPVcsNs......VSlKVpcANY+VPGRALRlTlcVTN+GDpPl+lGEFTTAGlRFlNusVhKc.DssYP-ELLAscGLShDssuPIAPGET+sV-lcApDAtWEVQRLuDLlYDPDSRFGGLLMFaDsoGNRplssIuGPVIPsFs	...............................................................................Gtcs.tsh.Rhpoh.aaD.h.at.............p.htls-.hshoGKhhlhtsWPp.slshPthuFhNhu.PuPshhRhtphlst....p..h..Shsl.hGts..YpaclplKARhPGpaHlHshlNVcsuGPllGPGtalslsGshssFpsslphLsGpTl.shEsashsphhhW..................................................................................................................................................................................................................................................................................................	0	7	12	15
+3391	PF03473	MOSC		MOSC domain	Aravind L, Anantharaman V	anon	Aravind L, Anantharaman V	Domain	The MOSC (MOCO sulfurase C-terminal) domain is a  superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.44	0.71	-4.68	30	4691	2009-01-15 18:05:59	2003-04-07 12:59:11	12	41	2815	8	1479	3587	1209	130.30	22	44.61	CHANGED	pGhss-.........sshphptus.............cpslhlhspcslstlpppls.pt...............ssstFttNlsl.....sGhs................Esphh....cphplGs..shlcVspspp.Chhhshch.........psuph............................hthhhtshh.GhhhpllpsGplpsGDslpl	..............................................t...............th.hphus...............spsl..h..lhsp...ps...h...t...t.....h..pp..c.h.s...tp....................................................shstF..t.tNlsl........................s.G..h.s.................................................Essh.h.............cth...+.l.....Gc..................sll..pVs....p.s..pp...Ch.th.sh.p.h.............ppsph.............................................................................................................................................h..t.h...h...h.s.......h......G..h.h..h....p.....l..l...p..s...G...h....l.psGDtlp...................................................	0	425	840	1217
+3392	PF02722	MOSP_C		Major Outer Sheath Protein C-terminal region	Bashton m, Bateman A	anon	Pfam-B_653 (release 5.5)	Family	This is a family of spirochete major outer sheath protein C-terminal  regions. These proteins are present on the bacterial cell surface.  In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and  fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola [1].	25.00	25.00	25.00	26.90	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.45	0.71	-4.76	8	373	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	20	0	10	327	0	169.80	53	36.12	CHANGED	DALL........ohQW+WlSsGsYhATAsuNVFGpplhspshosahDsAuFl+lETK.uGDPhT+LlsGLsuGV-sRlYIPhTatlYhsssu....t................th.sspIsLPVsGKsWsSY+IsLu-auWlKPasslYGsTNRhshss.u...........pphppthshtYcVGlohSPlEKVElcspWEQGpLucsPYhs........Ipcslos...cpa.GTFVCGlKlsW	...................DALLThtYRWhSuGuYFAotuoNVFtsshL.s.p..s.h.s.p.h.DhAAalKLETK..uuDP.TphLpGLDhGV-sRsYhPlpathhh......................................................ssssIphPVhGKsWsSYRhshG-YGWVKsYAslYGuTN+tsss.s.sus..................pphptEYCuhYcsGlshSPhEKh.h..h.............................................................................	0	10	10	10
+3393	PF02707	MOSP_N	MOSP; 	Major Outer Sheath Protein N-terminal region	Bashton m, Bateman A	anon	Pfam-B_653 (release 5.5)	Family	This is a family of spirochete major outer sheath protein N-terminal regions. These proteins are present on the bacterial cell surface.  In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and  fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola [1].	25.00	25.00	36.30	35.50	18.20	20.10	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.22	0.71	-4.74	7	405	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	20	0	10	364	0	167.70	49	36.84	CHANGED	laAElplKsLpVshpostsu..........t..as.spppsolEATLHCYGAYhTlGpsPsFhsNFApLWcPalsss.Ycpc..cspYAPGFsGhGGKlGY+ApsluuSGlslDluhLSFuSNGsW-utsos...................HSKYGFGuDhsLsYshtt....pchlplElAuNATLpptYppuspp.ssst..ppsplLWslGuRlTLpPhssF+hshAhDsGs	..............................spl.htsh.hth......................ht.ht.thp.hpATLHhYGAYhTlGpsPshhssFA.LWcPahspt.Yppc..ts.YtPGFtG.GG.KLGY+tpDIuGoGlohDIuF.pFASNssW-upsss.s..s..u.s.................................................................HSKYGhGuDlhhuatRsR....QEhl+VELsGNuTLu..sGYspu..sts..........s.......phstlLWsVGu+lohp.hhGhph.hA.........................................	0	10	10	10
+3394	PF01618	MotA_ExbB		MotA/TolQ/ExbB proton channel family	Bateman A	anon	Pfam-B_1099 (release 4.1)	Family	This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels.  MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller [1]. ExbB is part of the TonB-dependent transduction complex.  The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.57	0.71	-4.55	28	9835	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	2969	0	2514	6816	4219	133.80	23	52.20	CHANGED	hcthsshtth.thhshpphhthths.....htptthhctlphthppsh.sp.ttpLppshslLuTluusAPalGLlGTVhGIhpsFhslutsup...sshsslusGIupALlATAhGLhVAIPul.lhYNhlsppspthhtchcthtp	.......................................................................t........................................tt.h....h....c..t..l.p.t...t.h.c...p.th....pp....tt.p....ph..pp..shsh...L.uslu.u.hu...Ph....lGLhGTVhGl...hpu...hts......l...u...t............tt............ss...h.s.......h....l.......us.......GIupALl....uTshG.lh..sA.l.s.ul..hhashlpp.pspphht.hp....t.................................................	1	796	1613	2101
+3395	PF04006	Mpp10		Mpp10 protein	Wood V, Bateman A	anon	Pfam-B_12513 (release 7.3)	Family	This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites [3].	21.40	21.40	23.30	21.40	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	600	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-13.28	0.70	-6.15	6	429	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	298	0	297	439	2	435.40	22	88.04	CHANGED	plttlpussstFlhspst.usshcslsph.sh.sphp.cstscpsPLsplsh-uhDsEQIWpQLclpsc.lLssl.p.tst..p.hhspccIoshsc.p.p.pp-Dsp-..-.st.ppuDD-p-.c-.Ep......h......s..s.tEsst--.pt..sEss-.pc.-...........-.tt....p...tp.ppKch-spsl-DpFFcL-EhpcaLpptEcc..Ecut.s--cctc-h..D..pchpsD..................Fu.tc.ppsccptslpYcDFFs...............c.hp..pct-.p.pttsscch.cccu-pcp.cpsctD--.-ppps..p..p.......sh.sthc........--.s..tscpsuscphSSaE+cpt+lpp+IcpLEcEsLucKsWpLpGEVsAppRPpNSLLEccL-FD+sA+PsPVITEEsTcoLEDlIKpRIpDpsaDDV.Rps+lsssttch+cphpLscpKSKpSLAElYEpEYh+tsspph........sthspc.sctHpEIpphhssLhhKLDALSsFHFsPKPstsElcIVoNsPAlsMEEVuPlAsSDAthLAPEEIacssKstc...........hocsEhsppDKpRcRRpKKpKpp.................................Kthphstptpphts-tssp.shtps.shhsKht-pssss	............................................................................................................t......................................................................................................la......................................................................................................................................................................................................................t..................................................................................................................................................................................................hpD....tF...hphpphp....t....h...-tt...........t......t.....................t..t.tt...p................c.................................................................................................t...p...t......t..t.........h....h.tDh..ht.......................................................................................................................................t....................t...........t..............t.................................................................................................p....t.......t.......t.....t......t.....t........h...S.s.aE..+pp.c...............h.tpp..I..pplEtt.ltp+.WphpGEsputpRP.NSLL.E....p....s....Lc...F-c.s........s+..................sP.sl..............Tp...E.ho.............p...........lEp........hI+pRIhpp.........taD-.l..+p....................................................t....c.t............h...p.....lsppKup.uLu-lYEp-ah...p.tt....................tpp.p......t+tE..lp..phhppl..cLDuLSshH...ahPKss.......p.h.p.....l..h...s.....s...h.s..s.lshE.-stP.....h...s...h......u....s...s....s......h....lA.PpElht..t.t.t............................hs..ptEhotp..-.+t+.R...pt....tK....p.p..............................................................................t.......t................................................t................................................................	1	106	169	251
+3396	PF05172	Nup35_RRM	MPPN;	Nup53/35/40-type RNA recognition motif	Guo JH, Coggill P	anon	Guo JH	Domain	Members of this family belong to the nucleor pore complex, NPC, the only gateway between the nucleus and the cytoplasm. The NPC consists of several subcomplexes each one of which is made up of multiple copies of several individual Nup, Nic or Sec protein subunits. In yeast, this Nup or nucleoporin subunit is numbered Nup53, Nup40 in Schizo. pombe and in vertebrates as Nup35. This subunit forms part of the inner ring within the membrane and interacts directly with Nup-Ndc1, considered to be an anchor for the NPC in the pore membrane [1]. This region of the Nup is the RNA-recognition region [2].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.46	0.72	-4.26	7	252	2012-10-02 20:46:34	2003-04-07 12:59:11	8	5	191	5	164	260	2	95.70	32	25.66	CHANGED	ssspsusp......VhVFGFP.u.ss.lltcFupaGpIlcch..................................................hspsuNWh+lpYps..pAp+ALpcNGhlhssslhlGV..s..tsKplhstp	..................................................s....scpW.....VTVFG..FP..u.sushlLppFupaG..sI..lcch.....................................................hs.ssuNWh+lpYpSchpAp+ALp+.NGpl.hs..sslh.lGVp.s...h.cphht..p................	0	60	91	135
+3397	PF01188	MR_MLE		Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	C-terminal domain is TIM barrel fold, dehydratase-like domain. Manganese is associated with this domain.	22.40	22.40	22.40	22.50	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.73	0.72	-3.44	1272	5681	2012-10-02 01:07:48	2003-04-07 12:59:11	16	31	2337	582	1586	7550	3093	69.00	28	18.12	CHANGED	tl...pulRcs....hus.th...........t.lhlD.....s...N.........tu..............h..............p.pAlph...hctL.......p.p..........h.....h.alE.pPlss......tsh.......pshtp.l...p....p.ps....lP...l.sss	.............................h.ltsl+ct.....hP..-h........p..ltlD.......sN................tu................W.sh..........ppAhph...sctL..........s.s...................l....talE.-Psss........tph.........cshtp.h....p...........c.ts..........slP..lAs.............................	0	468	964	1332
+3398	PF02746	MR_MLE_N		Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports fold similarity with enolase N-terminal domain.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.34	0.71	-4.10	9	7573	2012-10-02 11:54:41	2003-04-07 12:59:11	11	23	2340	767	2008	5956	2681	111.20	25	29.06	CHANGED	tlpshlsssshs...Ph.huhtohtpt.hVllclp.s-GlsGlGEusshG.......ps.sltshlcsaLuPhLlGpDssplpshhphhh+ushs.....shoAtAAlDhALaDlpu+shshPlscLlG	.........................................................................................hhhh..........................................................t....h.....l......llc..l.p...s...-...s....G.......l.....s.....G...h...GE....s....s...s....hs..............................ts.h...t...s...t...l...p...c...........l..t....s.h......l.....l......G......p.......-....s....t...p....l...p.....p..........l.....h.....p.....t...h....h..p...t..h.hh.......................hshsA..h....uAl...D.......hALWDlh........uK.thsh.Plap.LLG.......................	0	558	1207	1629
+3399	PF04152	Mre11_DNA_bind	Mer11_DNA_bind; 	Mre11 DNA-binding presumed domain 	Wood V, Finn RD	anon	Pfam-B_3909 (release 7.3);	Domain	The Mre11 complex is a multi-subunit nuclease that is composed  of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication [1].  Mre11 has an intrinsic DNA-binding activity that is stimulated  by Rad50 on its own or in combination with Nbs1 [2].	25.00	25.00	27.40	25.20	23.20	24.80	hmmbuild  --amino -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.04	0.71	-4.41	56	403	2009-09-10 20:52:09	2003-04-07 12:59:11	9	9	297	12	239	389	1	164.80	32	24.61	CHANGED	aphpsIPL+TVRPFlhc-llLpcps.........pssscpclp.paLhp............p.V-phIccAppph.................t....tttcss..LPLlRLRV-Yous.................aps.NPpRFup+.FVG+VANss......DllpFa...+.+Kptpp................pptp.tptthht.pphsplclcsLVp-aL....ssppLslLscsshucAVppF	....................aphp.IPLcTVRPFhhc-ll.Lsccs................................psps.pppl..p..p.alhp............t.V-.phI-cAppph...........................................s.p.pps...lPLlRLRV-Yous.................apshNspRFup+..Fls.+VANsp......DllpFh..+++cpppt..............t............tttt.tpt.h....tt.pp.h.sshcVEsL...Vpcah....ps.pLplLspp.shscAlppF..................................................	0	81	132	200
+3400	PF04085	MreC		rod shape-determining protein MreC	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	MreC (murein formation C) is involved in the rod shape  determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.	28.00	28.00	31.50	30.70	27.50	27.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.64	0.71	-4.79	20	3591	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	3553	5	739	2380	2076	151.70	29	50.93	CHANGED	pVlsh.ssssasppllIs..pGppcGl.....pps.sVls....spG.LlGpV..spVsptoS+VhLLoDssp...plslplp..+ss.....................................................hp.GIlsGpsspp........tLplphls..sss-IchGDhlVTSGLG......GhaPsGl.VGpVsplctcsttht..t.htlcPssclpcLcaVhllh.s	..............................................................Vlsp.sss..s.appplsIc..+G..sps..G......l........tps.sVls..........spG.....lVGpV..s.pVsphoS..pVh.Ll.s..c.ssp......tlslplt...+ss........................................................................hp..ullp....G..p...s..s..ps...................Lplppls..........ssscl..p..h..G.......Dh..lV.T.S.G.L....G.........uh..aPpGlsVGpVspV.pp...c.s.tthh.....pplp.lcPsA.shpcl.chlhllh..s..........................	0	258	496	635
+3401	PF04093	MreD		rod shape-determining protein MreD	Finn RD	anon	manual;	Family	MreD (murein formation D) is involved in the rod shape  determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.02	0.71	-4.38	14	2682	2012-10-03 02:46:00	2003-04-07 12:59:11	7	2	2669	0	496	1464	599	156.00	23	93.18	CHANGED	pRhhhtallhls.hllullhth.hsh.ss....hhhhtPpaLhLhLlahslthsppsulhhuhlhGllaDlhhsullGlpshhhsllsallshhhthl+h......hshhhtshl.....l.h...hshllthllths.h.hlh.shap..Pph..lhshlluhlLh.hlhhLhptl	..................................h....h.hll.hl....hl...l.s..hl.lp......h...h......s..h..hs......hhhht.P...pa...l......ll.h...l.l...a.h......s.l.......t.......h...s...c...p...s..s....l......h.hua..lhGllhD.l.h..........h..u..u..........h..........l.G.lpslshsllsall.s.h.h...h....p.h.h..hp...........ls...l..h..h...ts..ll........lhl.......hs.hh...l...t...h..l.....l.h..h..s..p...h...........h.h...h.....l.......s.......h...p.........P.p.h....lhs.h..ll.t.slL.ashlhhhh...h......................................................................	0	156	313	416
+3402	PF03919	mRNA_cap_C		mRNA capping enzyme, C-terminal domain	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	26.50	26.50	27.70	27.30	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.68	0.72	-3.71	11	377	2012-10-03 20:18:02	2003-04-07 12:59:11	10	15	304	18	250	369	89	107.30	30	20.63	CHANGED	phNoVDFhLchsct....t.shL....pphGhlpah...........tt.s.....................+hssp.pphss+IlECpa..-p..psp...WhahRhRsDKopPNshsTscsVlpoIpssVTcEhLlc	..................................................................NolDFplclph....................ps..l.........p.s....hh......ah.......................................................tthp.......h........................t..phpp...p...hs...s+..IlECph...........-p....psp...................Wp.......hh.......RhRsDKspsNphsTsppVhpSIp-sVoc-tLl.......	0	96	147	211
+3403	PF01331	mRNA_cap_enzyme		mRNA capping enzyme, catalytic domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family represents the ATP binding catalytic domain of the mRNA capping enzyme.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.36	0.71	-4.61	12	521	2012-10-02 00:43:09	2003-04-07 12:59:11	14	25	354	18	336	652	333	173.70	27	35.15	CHANGED	pPlShs+.cthchLpppsYhVs.KsDGhRhhhhlsps........sahlDRc.phahlpthpaPhph..........hhphTLLDGEhllDhhtt.....tphRYLlaDhlshsGps.lsppshs..pRhphlp+clhpPpstth..psthhphc..PFtlphKshh.h.tsp+.h..htphhtplsHcsDGLIFpsscsPYssG.pspslLKWK	...................................................................pPVShs....p....pphp..L...pp..sYhVs..K....sDGhRhhhh..lstp...............tsahlD.R...p...ps..hhh.l.p.....hpaPh...........p......................t.h..hp...sTLlDG....E.h..l.h...Dph.s........................ttp.+.....aL.laDhlhh........s...............ups....l...hp...pshp.............pRlthlpcplhp..Pht....ph.....h...............p.....p................h.....hp.........tt.......................p....s.....F...........p......l.ph.Kshh.hh...thpp.......h..............ht.phh...............pl....H..t.sDGLIFp...s..h..p....t...sYh.G...psp.p.....lLKWK.........................................................................................	0	145	207	288
+3404	PF02940	mRNA_triPase		mRNA capping enzyme, beta chain	Griffiths-Jones SR	anon	Structural domain	Domain	The beta chain of mRNA capping enzyme has triphosphatase activity.  The function of the capping enzyme also depends on the guanylyltransferase activity conferred by the alpha chain (see Pfam:PF01331)	20.40	20.40	21.00	21.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.62	0.70	-4.60	24	259	2012-10-01 23:11:28	2003-04-07 12:59:11	10	13	212	14	161	256	64	210.30	23	42.20	CHANGED	.cshs+sls-alht................lpspshpplElEhKlGhlhctp....sspRhphsl.opslhspp.........pspFpsslscspapphpcaLpphs..............................................................t.t..hh.hshhcspppDphYpht...................tp.splRloh...Dsp...sschhtt...IcKcRlssl.lasPpssa..........................................DhRlSlslEhshs.s.......stsssps.thpRpKcRhSYh.+ss..h+hDLT+V..........s..tpscspppaElElEl	...............................................................................h...ltphhh..h..............h..t.....lElEh+hGhlhstp.........ptpRh..th..s...h.........s.tslhppt................thtFpsshs.....tttapthpphLpphs.....................................................................................................................h.hshh.cppppDphaphs......................tctsplRlop....Dtp........ssphhtt....ItKp+ls..slpl.a.Pp.s.s..h.........................................................DhRlSl..slEhshsts..................thtpp..s.t..hpRpKcRhSYp.pts..........hplDlTpV......................t...ttstptphpaElElEl...........................................	0	60	97	142
+3406	PF02349	MSG		Major surface glycoprotein	Bashton M, Bateman A	anon	Pfam-B_864 (release 5.2)	Family	This is a novel repeat in Pneumocystis carinii Major surface glycoprotein (MSG) some members of the alignment have up to nine  repeats of this family, the repeats containing several conserved  cysteines.  The MSG of P. carinii is an important protein in  host-pathogen interactions [2]. Surface glycoprotein A Swiss:O59920 from Pneumocystis carinii is a main target for the host immune system, this protein  is implicated in the attachment of Pneumocystis carinii to the host alveolar epithelial cells, alveolar macrophages,  host surfactant and possibly accounts in part for the hypoxia seen in Pneumocystis carinii pneumonia (PCP) [1].	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-11.10	0.72	-4.01	205	505	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	3	0	0	514	0	90.30	24	46.08	CHANGED	pphht-ppChp.htptC....Lpps.........Cp.php......................Cpp....l+cpC...p.phppctp..................................................hpphhhpph+s.....plpsc....pcCpctL.pc.C.thpp..sp	........................................p....h-ccCtc.htpcChh.Lpps..st..phptp..............CppL+ppCtphthpph.....................................................................hpchLhcthcs......shpsc......pcCpctL.pchCspLpc.tp.t..................	0	0	0	0
+3407	PF04066	MrpF_PhaF		Multiple resistance and pH regulation protein F (MrpF / PhaF)	Kerrison ND, Finn RD	anon	COG2212	Family	Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation.\	      It is also involved in symbiosis in Rhizobium meliloti [1].  MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis.  MrpF is thought to be an efflux system for Na+ and cholate [2]. The Mrp system in Bacilli may also have primary energisation capacities [3].	21.30	21.30	21.30	21.30	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.36	0.72	-3.69	16	1647	2009-09-11 16:03:59	2003-04-07 12:59:11	8	2	1250	0	488	1048	205	54.60	31	57.36	CHANGED	hsDRVlALDslsstllullsllulhhpphhhlDlAlllulLuFluTlAhA+altt	........................sDRllALDslsh.shullslhulh....h.s.s.s.hal-shlllAlluFluTluhu+Fl.........	2	147	300	407
+3408	PF04471	Mrr_cat		Restriction endonuclease	Waterfield DI, Finn RD	anon	COG1715	Family	Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.69	0.71	-4.28	227	2560	2012-10-11 20:44:43	2003-04-07 12:59:11	7	96	1770	1	790	2681	416	113.70	20	32.61	CHANGED	l.p......p...hs.stpFEclltp....lhpp.h..Gap.......s..p......h.st.t.us.Ds...G..lDl...l......h...p.p.s....u......p.............p..h..hlQsK+a.....p........s..p...luh.pt.lpp.h.hu.s.h.p..t......p.p....us......p......GlhlT.o.us...Fo...psA....p...ph.A....p..p.....p....p........lpLl..DupcLhchl	...............................................................h...hss.tFEphltp....lhp.....p...h...Gap...................s.p.............h.st...t..ss...D.t.....G....l...Dh..l................h...pp...s.t....t.......p..................................ph...hlQ.sKca........p..................s..p..........lu.t....tt....l.p..p...h.hu...s.h.t..t................h.t.......ss................p..........................ulhl..T..s.us.....Fo....p...sA....p....ph.A....pp.......p....t..............lhLl..stppLhph............................................................	1	266	525	668
+3409	PF00924	MS_channel	UPF0003;	Mechanosensitive ion channel	Bateman A, Martinac B	anon	Pfam-B_1136 (release 3.0)	Family	Two members of  this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterised. Both proteins form mechanosensitive (MS) ion channels upon  reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	20.70	20.70	20.70	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-10.89	0.70	-5.00	37	13351	2009-09-13 17:39:23	2003-04-07 12:59:11	13	28	4579	14	3447	9838	4024	200.60	21	41.76	CHANGED	tplhphllhslshlhsLshlGhs...hsullushGhhGluluhuhQshlsslluGlhllh-+.shclGDhlpls...............shpGtVpclslpsTpl+sh-sphlhlPNsplhsppltNaop...pstpRlphslslsasos...hcplhchltchhtppstlhp................................................tshlhhsphussulshplpsasps.......tchhslppplthc.........lppthccpsIph	......................................................t..lhph.h.l.h.h.l.s...l...l..h..h..l.....s..h..l...G.ls........hs..s........l...l........s....s....h....G........s....h.u..l....u....l....G....h....u.h...Q..shlss.hl........uG....l....h.l.l.h.p.c..shclGDh.lp.ls..............................................sh.p..G..s....V..p..cI.....s.l.p.........s.........T.p.........l............p.........s...........h...........D.........s.....p.....h.....l..h.lPNstlh.s.t..s.l..t..Naot....................shtc....h..t..h.s..l...s.l.s......h.....s..s.s...............h.p........p..h.h...p.h........l.....h.....p........h....h...t...p...p....s..t..l.hp...............................................................................p....t..........l..h....h...t...t...h...s...t..s...s...h...s...h...t...lt..h..a..sps..................t.p..h...h.t.....h..ttplhtp.........lhphh.pptslp....................................................................................................................................	1	1007	2127	2858
+3410	PF00985	MSA_2		Merozoite Surface Antigen 2 (MSA-2) family	Finn RD, Bateman A	anon	Pfam-B_1052 (release 3.0)	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.00	0.71	-4.12	5	652	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	19	0	1	531	0	103.60	55	57.25	CHANGED	TTTTTTTNDAEASTSTSSEN.NHpNAETNPKGcGEVQpPNQANKETQNNSNVQQDSQTKSNVPcTQDADTKSPTAQPEQAENSAPTAEQTESPELQSAPENKGTGQHGHMHGSRNNHPQNTSDSQKECTDGNKENCGAATSLLNNSSNIASINKFVVLISATLVLSFAIFI	.........................osoToTTNsuEupToTso..............sA-Ts......spscu.ps.p..Ps.....sspEopssuN..s.pcopsKup..s..pQst.scSspttPc...............APpt.QTtpsE..usP.-N....................................................................................	0	1	1	1
+3411	PF01741	MscL		Large-conductance mechanosensitive channel, MscL	Bateman A	anon	[1]	Domain	\N	22.40	22.40	22.60	22.60	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.71	0.71	-3.99	8	3477	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	3349	6	744	2091	328	128.40	42	92.61	CHANGED	hlKEFKEFAhRGNVVDLAVGVlIGuAFGKIVoSLVsDIIMPllGhLlGulDFu.sluh.h....G...........hsusslsYGlFIQslINFlIIAFAI.FlsIKsIN+L....++KcEs....ps.A.s-....sppsLLTEIRDLLKpp	...........................hlKEFK-Fh.hRGNVlDLAVGV..IIGuAFupIVoSLV...s...DIIMP.l.l.Gh.l..l....G..u..l....D.Fs...sht.h.h.........st...............................h.s...s..s.slpY...GsFIps.l.....lsF....lIl.A....Fsl...F.h..h...l.....K....h....l....N..+...l.................p..+..+...c.c..tt......t...t.s.....s....ss...........pp..LLsEIRDLLcp..............................................	0	218	475	634
+3412	PF01716	MSP		Manganese-stabilising protein / photosystem II polypeptide	Bashton M, Bateman A	anon	Pfam-B_1814 (release 4.1)	Family	This family consists of the 33 KDa photosystem II polypeptide from the oxygen evolving complex (OEC) of plants and cyanobacteria. The protein is also known as the manganese-stabilising protein as it is associated with the manganese complex of the OEC and may provide the ligands for the complex [1].	25.00	25.00	37.30	36.80	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.58	0.70	-5.31	8	265	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	197	17	67	285	155	210.30	51	79.74	CHANGED	-hQsLTY--I+uTGLANpCPsLs-ssRGolsl-uGppYtlscLCLEPosFhVKEEPsNKRQcAEFVssKLlTRhTooLDQIpGclpVsuDGSlTFpEKDGIDFQAlTVQLPGGERVPFLFTIKNLVApTpPshoSlsoShDFcG-FpVPSYRGAsFLDPKGRGluTGYDN..AVALPusuDcE-Ls+pNVKpsshuKGpISLpVuKVDusTGEIAGVFES.QPSDTDLGAKEP+DVKlpGlFYApl-	.....................pshTY.plKGTGhANpCPslssu...ts.sh.slcsGp.YphpchClEPToFtVKt....E.s.hs..K.pt...t....s..-..F.pTKLhT.R.hTYTLDp........lpGshpVssDGslpFp.E.cDG..IDaAslTVQLPGGERVPFLFTlKpLsApupsss...................FuGpF...hVPSYRGusFLDPKGRGssTGYDpA...VA.L.P..A.....t..u....D.....p-....-L.+EN.K..ph..ts..spGplshpls+scspTGElhGlFpS.QPSDTDhGuK..Ph-VKlpGlaYupl...............	0	21	48	60
+3413	PF03429	MSP1b		Major surface protein 1B	Finn RD	anon	Pfam-B_4414 (release 6.6)	Family	The major surface protein (MSP1) of the cattle pathogen Anaplasma is a heterodimer comprised of MSP1a and MSP1b.  This family is the MSP1b chain.  There MSP1 proteins are putative adhesins for bovine erythrocytes. 	25.00	25.00	231.30	62.20	20.90	22.80	hmmbuild  -o /dev/null HMM SEED	726	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.50	0.70	-13.29	0.70	-6.64	5	35	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	4	0	10	61	0	481.30	64	97.78	CHANGED	MTEDDKQQQQNQSNVVQAISAVFQRKSAELQRLNDFIKGADGTLKNVHPHMKSLEALSKQLSEKIAAEAAAKADAKYESVGLRAKAAAALGNLGRLVARGKLKSSDAPKDLDQSIDALPFMDEAPDTGERVVVPAGEEQEFGKAAAWGLAGFKRTVDESLEMLGRGMNMLAEGQAQISQGIADKSTALVREGLETSRLGAGLCRNGLVEASYGVGYANETMGKYAGKGLEKCKNKLGDACYKWSKALEEIENLRTAIDAKAEQQVEGEAWSPEGVSANTFYRGLHKIGAAIAVAAQATWEGLAMTGKFMGAVAKLAGAVSMCVAAYTAAIVGMAAATPATLLLTAMDNQS.VNNAVVKVSEYLHSNVEQATKDLMASEFAMMTFGGIMTCAKLMKGSFAAINQKFEEINATLTREATDIAQGIKETYKSIGDAF..................KSANDGIAKWT.....AALAGYASVEQLEEAKEADRAQAEQRAEAQAMTERVAGERAATVAAGTETIKTIVS..................DMCNELAQIGGLSQAERDALVQSFTPKPPARTTKEIVSQMCNSVKSAFGSISHITNVIRQAGKDAQKIDPQVEVAEISPETIYAMSEALYALNMQESAsINNALLAAVNDSSKDDQAIVTDLINATIEVCTEQTNTLAGHTAEVQAGLEAAGIKLDDAQGLQEATPEA.KGVEGINPEELEQAAEGLATAVNEASADGKIQSLNQQETQIAQGGQHAAQQQSSGWSR	...............................VhQthpAtht+.NthlcthDsh.K.h+.pMpsL-ALpppLppKhA..tEsssKhsthhtSsuLRAKAsA................................M-ps..PsshE.h.s.hGEE.pEFG+AsAaGLsGhK+TlDEulEMLsRGMpMluEGQAplupGltsKsstlV+tGLEhStLGsuhChpuLs-hoaGlthspc.sMGKhAGKGL-KC+pKLtsAs.KW.pAhpEl-sLRTAI.....-t......tAtppsEGEAWSPcGVpuNsFY+uLppIGttIAsAAQATWEGLAMTGKFMGAVAKLAGAVSMCVAAYTAAIlshh...hPAsl.LshMsspS.lsphVs+sucYLHSNVEQATKDLMASEFAMMTFGGIMTCAKLMKsSFAAlNQKFE.ElNATLs.RcuTDIsQGlKEsYpSIGDAF..................KSsNsGIAKWT.....AAlAGYASVEQLEEAKtADRsQA-QpAEtQAMscpVAttRAATVAAGTtTIKTIVS..................DMCNELAQIsuhSQAthsA...........................................................................tEuthlpsALLtAVNDoSKDDQAIVTsLINAsIEVC..TcQTNTLAGHTAEVQttLEAAGl+h-DAp....ss.pt.KGhEGIN.EELtQAA................................................................................................................................................................................	0	0	0	10
+3414	PF04421	Mss4		Mss4 protein	Bateman A, Wood V	anon	Wood V	Domain	\N	21.20	21.20	27.90	21.50	19.50	19.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.38	0.72	-4.15	5	159	2012-10-01 21:11:27	2003-04-07 12:59:11	8	4	136	5	109	153	0	95.40	32	61.01	CHANGED	sscsllNpcc.shV-hPLhsp+pcR.......t...........Dssss-.lc-FaLVKDM.....FsFENVGFS+slc.shKaLVCADCE+GPlGaaDhsscpsa.luLERVsHp	.........................................................................................................h...httt...............t..................sssss-h....lptaWhVp.DM.....asFENlGFo+s.................Vs.....s.....h..............KaLlCADCEhGPIGapsh.s...s+psa.lAhcRV........................	0	38	53	90
+3415	PF03940	MSSP		Male specific sperm protein	Finn RD	anon	DOMO_DM01786	Family	This family of drosophila proteins are typified by the repetitive motif C-G-P.	21.20	21.20	21.50	21.80	19.90	21.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.52	0.72	-10.77	0.72	-4.57	3	8	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	6	0	4	8	1	45.20	74	47.76	CHANGED	CGGPC..CGPCGG..CG....PCG.G.CGPC..CGPCGPC...CGPCGPCGPCCGsscsaCGC	.ssGPCCGPCGG..CGPCGG.CGPCCGGCGPpCGPCGuCGPCCGsspsaCGC........	0	3	3	4
+3416	PF05063	MT-A70		MT-A70 	Finn RD	anon	Pfam-B_3025 (release 7.7)	Family	MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A  methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs. 	21.50	21.50	21.80	21.80	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.38	0.71	-4.71	10	995	2012-10-10 17:06:42	2003-04-07 12:59:11	9	19	544	0	535	970	231	158.10	28	43.04	CHANGED	FslIlhDPPWc.+hhtt.t.....plsYsshsp--lpsLslscLtsc.psllFLWsTspthhps...+psLcpWGachlsc.lsWlKsNphscslt..shpssphhp+spEHCLlGlKGsspp.hst..hptth.....spslIlu...hctpS+KPsElatllE+ls.....stc.+LELFuRs..l+PGWholGsp	......................................................aslIhhDPPWp.........t.............................t..Y.ss....h.....s...........p-.....lt.pL..s...l...p.l..s.....sp....sshlalWss..s..tt..h..ts...........hchl..p....t....W..G.....a....ch.h....sp..hhWlKhs.....p.t..t................p....hh..................................th...........st......h...hp..pspEphLhu.h.+.......Gss.p....t.....t..........................t..................pppllhu................http.....S........+..K............Pst.....hhph..l-phh......................ssht..+lELF.u..Rp.........hpsGWh.shGsp.............................................	1	194	302	434
+3418	PF01993	MTD		methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This enzyme family is involved in formation of methane from carbon dioxide EC:1.5.99.9. The enzyme requires coenzyme F420 [1].	25.00	25.00	142.50	142.40	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.46	0.70	-5.36	4	55	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	54	54	41	57	4	271.60	56	99.53	CHANGED	VVKlGlIKCGNIGTS.llDhLLDERADRcDI-VRVVGSGAKMsPEplE...csshchlcEh-PDFlIaluPNPAAPGPpKAREhLutushPAlIIGDAPGL+VKDEhEEQGLGYIllKsDsMIGARREFLDPsEMAlFNADVlKVLAuTGAaRlVQEAIDchI-clKtGK..psELPplVIsppKAVEAtcFoNPYAKAKAMAAapIAEKVADlDV+GCFhppDsE+YIPIVASAHEMhRhAAcLADEARElEKuNDsVhRsPHu.-GKhLSK+pLMtKPE	.VVKIGIlKhGNIGhSsllDLlLDERADRpDIsVRVlGSGAKMsPEplE...cssschlp-h..cPDFlIhISPNsusPGPppARElLtttslPsllIuD.uPuhK.s.K..D..t...hccpGhGYIIlKsDPMIGARREFLDPsEMAhFNuDllKVLAsTGAlRlVQptlDcsIcslctGK...-lcLP+IVlos-KAVEtupFsNPYAKAKAhAAaphAEKVAslDVKGCFMsK-hEcYIPlVASAHEhhRhAAcLsDEARElEKusDuVhRpPHupcGclLsKscLhpKPE....	0	9	28	35
+3419	PF02536	mTERF		mTERF	Bashton M, Bateman A	anon	Pfam-B_1422 (release 5.4)	Family	This family contains one sequence of known function  Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer [1].  The leucine zippers are not implicated in a dimerisation role as in other leucine zippers [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.04	0.70	-5.86	15	1485	2009-01-15 18:05:59	2003-04-07 12:59:11	9	25	144	8	968	1433	16	187.20	13	64.71	CHANGED	LsLh+ShtFosSpISoI......IpsYPplLlscscpoLssKLpaLpS+GASpS-lTclVSsVPcILupcth+olushaDal+cllhs..DpuSphE+hspsLspuspp.sh.pNlulLR-LGlsp+lLhsLLlSchpPVsG+......cph-tplccllEhGhDPsss+hVhuhp..llhphsDKslctpVshh+sLGFslsDVhslhp+tPphLshSpcp...h....................K........t.p.llsoIEphlu..........LGFSR-EhthMV+RaPtslshSsEp.VK+KhEFlVKcMshPl+slVphPpVhuYSLEKRhhPRssll+sLhSKG.......cLsslSpsLssTDppFLp	..........................................................................................................................................................................................h..............................................................................................................................................................................................................................................................................................................................h.............h..h.h...t......h.t..........t.......h........h...........h.................hh..............................................................................................................................h.........tht.hh..p.....................................hG.hs.tppl.h...t...h..lhp.h.P..ll...t.h.............s.cp..lp.php.ah........ht...........h......th.............t.........l....h....t.........P..hh..ht...h..........................................................................................................................................................	0	188	543	757
+3420	PF02219	MTHFR		Methylenetetrahydrofolate reductase	Bateman A, Mian N	anon	Pfam-B_2407 (release 5.2)	Domain	This family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and  methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known [1] to be a TIM barrel.	19.90	19.90	20.00	19.90	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.62	0.70	-5.32	12	4458	2012-10-01 19:29:00	2003-04-07 12:59:11	12	9	3842	40	1248	3279	1590	271.20	29	75.03	CHANGED	plpphhp..puchhhSaEFFPPKTspG.pNLhsphcRhptht.PhFlsVTaGAuG.....spt.chohslspthppppsl-shhHLTCsshshttlcptLcphhphGlRNILALRGDsPtstc..atp.ptt..hpYAhDLV+hI+p....caGDhFsIuVAuYP..EsHP......psts...hptDlhaLKcKl-AGADFlITQhFa-s-sal+FhspspstGh....shPIlPGIMPIpsacphp+hsphs.pspIPpplhsplp.sl+sD-psl+plGlchth-hspcLlspG...V.slHFYTLNhEcushtIlcpLG	..............................................................................................................t..........tp.slShEhaPP+......s......t....p...h..t......p..pl...h.p.s.l.c.p..Lpt....hp...P..cFl.oVT.auus.u..........................s.p.c.pp.Thphs...p.tlp...p........c...h....ul........p..shsHLT.Ch.s.t.s.t.....p..clpphlts.h.t.p.hG.l.c.pIlA......LRG..D....s.t...s......t...........................s...t....s.....s..............h.p..a.A..s-.L......l...p.h.l+.......................phu..c..............F.......s.......I.u....l...A...u.....Y..P.........Eh.HP....................................cu.p.s......hps..Dl...t..p..L+c.K....l....-....A......G.....A....s.....h.....hI.TQhF.FD.......s....-....p....ah....cF...h...-........c....s....tt.t.Gl.........s.l.P.I...lsG.....I..h...P.l.s.......s.h..p.p.ht..+..h.s..p.hs..ss.c..lP..ph..hhphh-....t................h.........c....s......D....s......p.........s....hc...t.h...G.h..p..h...u...h-...h...h...p...pL......h....p...p.G............l.......shHhY.T.hNpsphshtlhp..................................................................................	0	432	804	1058
+3421	PF05068	MtlR		Mannitol repressor	Bateman A	anon	COG3722	Family	The mannitol operon of Escherichia coli, encoding the mannitol-specific enzyme II of the phosphotransferase system (MtlA) and mannitol phosphate dehydrogenase (MtlD) contains an additional downstream open reading frame which encodes the mannitol repressor (MtlR).	21.50	21.50	21.50	21.90	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.03	0.71	-4.82	4	1088	2009-09-11 14:05:50	2003-04-07 12:59:11	7	2	679	8	70	326	4	169.90	49	95.31	CHANGED	Msshs.......................EsclLE+LNtscolRuFhhTuVslLsEAlctLl.plF.RKD-aAVK.sV-PLLssoGPLsDLoVRLKLlaGLGlIs+plapDIpHhhpl+cpLNcDspEYsFsDs.Ils.IppLsslschuhL...shct.-ssD.SlYphphtRhpphl+SsLoLAlTplhppLsh	....................................................hp...EscVLEpLsAscslpSFhhTAsplLspulphLl.plF.+cD-aAVcY.AVcPLLs..tsG.PLuDloVRLKLIYuLGlls+t.YpDhphhhtl+ctLNc-ss-huFsDDtIls.hup..L.p..sl..s..s.s.........s...t.h.c..ADhulauh..tRapphV+oshsLulTpllpclo.h....................................	0	6	21	46
+3422	PF03083	MtN3_slv		Sugar efflux transporter for intercellular exchange	Bateman A	anon	Pfam-B_623 (release 6.4)	Family	This family includes proteins such as drosophila saliva [1], MtN3 involved in root nodule development [3] and a protein involved in activation and expression of recombination activation genes (RAGs) [2]. Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter [4].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.83	0.72	-4.11	25	2182	2012-10-03 12:15:12	2003-04-07 12:59:11	11	19	651	0	1265	2047	467	83.20	24	68.44	CHANGED	.hlGhlsssholshFhuPLush.tpll+pKSs-shshh.hlsshlsushWhhYGlhhpDh..hlhhsNslGshltsl.llLalhYs.ccp	...........................h.hlGhlushhulh.hahu..s...........l..........sh..hhp..lhp.....s.+...........os.p.t.hs.h.h.....lsshlsshlW...hhYG...l.....h.....p.....p...Dh....hlhhsN.s..h.......Gh.l.huh..lhhhhahha.....t...........................	0	350	759	1105
+3423	PF03821	Mtp		Golgi 4-transmembrane spanning transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.40	22.40	22.60	22.80	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.65	0.70	-4.97	3	234	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	71	0	98	196	0	190.60	37	71.58	CHANGED	HlVMSVLLFIEHoVEVAHGKuSC+h.pMsYLRhADLlSSFLLIssLFIISlSLLIGVVKNREKYLlPFLSLQIMDaLLCLLTLLGSYIELPAYLKLA.RsRsuuSKlPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEDlPHsQFIsMMlIFSVAFITVLIFKVYMFKCVWsCYKaIKsMNSsEEcssSKMhp..KVVLPSYEEALSLPsKTPEG-PAPPPYSE	..................................................................................................................................................hhs..shshh.hslshLhhhhsthhsYGshp..........p......p.suallP.FFChQLFDFsLosLsAhSsls...YlPslpcalsp..........h.Pa+-clhphss.....sLhl...Illlhahhllhh....K..uYhIsCVWsCY+Yl..ps+..N.ss-.........h..s.....sth.t.........phl...L.Ps..Y-.Ah....p..ttp.ssPP.hs.......................................................	1	15	21	45
+3424	PF04208	MtrA		Tetrahydromethanopterin S-methyltransferase, subunit A 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	25.00	25.00	27.10	25.70	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-4.82	6	110	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	65	0	76	111	15	167.80	46	71.55	CHANGED	K+cPAEGWPlVpGDYlVGDPESsVuVVTLGSHlp.csslcAG....AAIuGPCKTENLGIEKVlANlISNPNIRFlllCGuEVpGHITGQohcALHpNGVD.-st.IIGApGAIPYlENlscEAVERFp.pQVElVDLIDlEDh-pIsptl+EClpKDPGAh-E-PhllclpE..GtcEEEEss	...........KKtPAtGWPllpG-Yhl..GsPcSsVAVlTLGS...........Hh.....ps.slc....A....G.......................AAIsGsC+TENLGIEKllANlISNPNIRFlllsGsEVp...GHloGQslhALacNGl...sc...-G...+...IlGApGAIPFlENlsp-ulcRFQ.ppV.EllDlI-sEDhutIpstIc-shuKDP.GAhtt.-shllclpt..tttt......st.......................	0	17	47	62
+3425	PF04211	MtrC		Tetrahydromethanopterin S-methyltransferase, subunit C 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	25.50	25.50	25.60	89.50	23.40	25.40	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.61	0.70	-5.34	4	55	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	53	0	40	55	5	258.60	39	98.46	CHANGED	MSs.uuGGcAtt.....uhP.pplMAlGIlsGLlGhYhush.ss..ltslhuuLuAlsAsVWGADAVRRVAuYGLGTGVPSIGhhuLGhGhlAAlhGlulsus.slPhhAAPIlullluAllGsllGsLsp+lltMKIPIME+shsEISsAGsLulLGhosAlAGSashpuVlshVlAsGhIALlFIlsuMuILHPFNACLGPsEsQcRTLhLAspsGhIshhlA........GLhshsls.....shLlGhlhWhlsFhKFhphoh+DAsuVlaoGhlPKpE	....................huh.usuu.Att.....hhPpsplhslGlluuLlGIYlu..thhss.....lh....shlGGLuAlsAhVhGAsslR+VAuYGLGTGVPSIGMluLGhGlluulhGltlush.......................s....h........s........uP......Il.......ulllAhllGhllGhLus..pslsMKIPlM.puhscLuhAGALulLGhosshu.Guash..s...............sll...............s...............sslssGhIAlhFIhuuhAILHPFNACLGPsEspcRTLtLAltsGhluhllh.......................ulhshshl..........sllluhlhWhlsatpalphohcDAssVhhss.lPct.............	0	9	26	34
+3426	PF04207	MtrD		Tetrahydromethanopterin S-methyltransferase, subunit D 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	25.00	25.00	58.50	58.50	21.90	21.60	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.59	0.70	-4.96	4	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	53	0	40	55	5	213.10	54	91.73	CHANGED	MDhll...lhhhhITlGGllIssuVHFVPVGGAPAAMATATGVGTGTsQLAAGAGLTGLloAAsMs......spshhlIhhuGAVGuMlMlulTMLVGslIYVYGVGsVPsSAKVclDPITthcQ-hYVTPGTEGHGlPTVsFVSGIIGGuLGGIGGuLlYaALhclhhs.u...huss..........VAuIhAlGhFFlNAVlASYNIGGTIEGFHDPKFK+hP+uVVuSLVASI	.................................llslhtIsIGGslIuhuVHFVPVGGAPAAMApuTGlGTGTs.LAAGAGhTGLluAAshst..............................s.shhllhhoGAVGuMlMhulTMllGshIYVaGlGlsPAuuKsphDPITtDpQc.YloPGTpGHGlPTVsFVSGlIGuhLGGlGGuLlYhuLhp.lsh.s.....s...........s...........l..AulhAlGhFFlNAVlASYNIGGTIEGFHDPKF.K.+hPpulluuhlASl..................	0	9	26	34
+3427	PF04206	MtrE		Tetrahydromethanopterin S-methyltransferase, subunit E 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1]. 	20.20	20.20	20.30	131.00	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.92	0.70	-5.38	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	55	0	38	57	5	270.60	54	91.35	CHANGED	LGlLALhGAuATIAGAuEDLESDVGSQSNPNSQVQLAPQMGNlHRaFNKAISGEPVSYuLaCuIAGoVAaVlMpphsLPslhALAlGAuIAAhVHssYAlTAaLGRluS.uupFsQPlYLDMlhSHLGPIAGHGFIsTFCIVulAYLMTllLs...HPFPLPLLAhIWGITIGAIGSSTGDVHYGAEREYQ+YPFGGGlPVAsHGDITRKAEhGlRNuMDsuaFCAKaGGPLTGLAFGLIVFLusWssllhs.....ttGulIs......hhGLlIVhlLIIhN	.....lGslALhGAhATlAGsAEDLESDlGSQSNPNSQVQLAPQMGplHRhFNKAISGEPluYGLasuluGulAasLh.......ths....hs..sllAIslGuslAAhVHGsYusoAalGRhsu.ppcFsQPlYhDllpoHlssIhuHuFIAsFshlshuYLhs...ss..Lu......pPF..PLPLlAlIWGITlGAIGSSTGDVHYGAEREYQph.FGuGlPlAspGsIsphAEhGhRNulDsuaFCuKaGGPlTGlsFGLIVFL-hWRollFs.....thG.u.lls..............hGlllVllhhlhN.............	0	8	24	32
+3428	PF04210	MtrG		Tetrahydromethanopterin S-methyltransferase, subunit G 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	21.50	21.50	21.60	58.60	21.40	20.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.32	0.72	-4.30	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	54	0	38	48	10	69.20	41	66.95	CHANGED	--K..lPpslssss-apclpcRLD-IEcKlEFssuElhQ+hGK+lGRDIGILYGlVIGLlL.hIhsllshhF	........s.....lPtslsssp-apcl.c+LDcIEcKVEFssuElhQRhG+KlGRDlGILYGlllGll.lhll.h..h....h.........	0	8	24	32
+3429	PF02007	MtrH		Tetrahydromethanopterin S-methyltransferase MtrH subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The enzyme tetrahydromethanopterin S-methyltransferase EC:2.1.1.86 is composed of eight subunits [1]. The enzyme is a membrane- associated enzyme complex which catalyses an energy-conserving, sodium-ion-translocating step in methanogenesis from hydrogen and carbon dioxide [1]. 	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.68	0.70	-5.42	6	101	2012-10-03 05:58:16	2003-04-07 12:59:11	13	2	81	0	68	133	38	294.50	41	94.20	CHANGED	KEQcVh-IuGVKIGGQPGEhPTVLAGTIFYu+HKIVcDEc+GIFD+-AAEsLIppQE-huDtTGNPhllplhGpTPEAIl+YIDFVA-loD.uPFLIDSopG-lRhAAAcaAoElGLADRsIYNSINsSl--uEI-ALspSDlsAuIVLuFNsMDsoVcG+lplLEsGu.ust-KGhLplA-cCGI.Kh.LIDsAlTPlGsGAGsAl+sohslKuKaGhPlGSGhHNsPSAWDWLRca+KcptEttt.........ssDlGoNllQthAuuDFlLYGPIENA.hlFPAsAMlDhhIuEAs+.-lGlEss	.............................................+cQpVh-luGsKlGGQPGEaPTlLsGoIFYspHcIV...pDtc+GhFD+ptAEsLlscptEhSDhTGNPthlpl..hu..pos.....E....Ahp+Yl-Fls...-ls-.sPFLlDSosu-sRhuusc.h.s.sElGls-RsIYNSINhuhs..c..p..E.l...c...ALp..c..Sclc.uuIlLuF...ss..h..D..s.o.lpG+hplLpsGu.ts.ccGhLplAc.csGIpp...LlDsAlhPlGsGuGh.uh...RushslKu+aG.hP...sGuGhHNssSuW.cWL+ch+Kp.ht.phht................................ssDlGuNllth.htGuDFlLYGPI-NAthsFPAsAhsDhhluEusc.-hGht..h..............................................................	0	20	49	58
+3430	PF05175	MTS		Methyltransferase small domain	Yeats C	anon	Yeats C	Domain	This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other  methyltransferases (eg Swiss:Q53742).	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.93	0.71	-4.88	34	8728	2012-10-10 17:06:42	2003-04-07 12:59:11	9	24	4157	22	1810	48732	14113	160.50	23	53.65	CHANGED	phphpohsGVFStsclDhGoplLlpslst...hsup....llDlGCGhGlluhhhuctsPchp.lshsDhsttAlpuu+tshpsNtlc....sclhhuDlhssht..tcaDhIloNPP.............FHsGt.sht.tlspchltsAtptLpsuGcLhlVuNcpLsYpsh...lcchFG..pschlscsstaplhp	............................................................................t................................................................h.....h...t.........h.................ttp....................lL.DlG...s...G..s.G.........s....l.....u..l....s....l...........A...........p..........t..........t........P............p.............h.............p...........l........s........h.......s...........D......l........s........t......p....A.........l..........p.......h......A.........c.......p....N.....h.............p........p................p.............t.........l.........p..........................l..............p...............h..............h.........p............u.............c.............h..............h...............s..............s.................l..............t....................t............p.............a...........D..........h.......I......l..o......N....P......P................................................h....t......s........up.....p...............s..............t...........h......h........p.......p........l........l....t.......p.......A....h.........p...h.L.p..s.s......G.......L.....h.......l...........h....................................................................................................................................................................................	0	525	1050	1457
+3431	PF02416	MttA_Hcf106		mttA/Hcf106 family	Bateman A	anon	Pfam-B_1826 (release 5.4)	Family	Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts [2]. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif [1].	20.50	18.00	20.50	18.30	20.40	17.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.51	0.72	-4.85	12	5974	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	3284	1	1554	3673	2404	70.10	27	71.89	CHANGED	luhschllIhlVslllFGsKKLPEluRuLG+oLRtFKpAs+phpst..............................pcpptpc	.......luhhcll.l..l..h.l.l.s.l..L..l.F..G.s....c.K.LP....p....lups....l.G......p.......u...l.......+.......tFK......c....uh.p.-..ptt.....................................pttttttt..t............................................................................................................	0	510	1045	1336
+3432	PF02316	HTH_Tnp_Mu_1	Mu_DNA_bind;	Mu DNA-binding domain	Mian N, Bateman A	anon	Pfam-B_12856 (release 5.2)	Family	This family consists of MuA-transposase and repressor protein CI. These proteins contain homologous DNA-binding domains at their N-termini which compete for the same DNA site within the Mu bacteriophage genome.	21.60	21.60	21.60	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.77	0.71	-4.48	4	448	2012-10-04 14:01:12	2003-04-07 12:59:11	11	15	279	6	72	410	4	108.40	21	26.71	CHANGED	pchsGhPGlPphssGVphhAptpGWpKpp+pGsKG.hAhEYclsSLPpEsRttllt.........uAuhsEhsspo.hhcshsppllhshppLssDppptslchl....l....Phl.stDchhsthGhoppp.tTLhhh.Alssp	......................h.GlsGlPpospGlp....h....t....A+.+.....-.uWt....p........R.....+..R..........pGh.....pG...uhEYplsSLP.psptt.l...h....................................................................................................................................................................................................................................................	0	16	39	58
+3433	PF02914	DDE_2	Mu_transposase;	Bacteriophage Mu transposase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.30	20.30	20.60	20.50	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.41	0.70	-4.83	2	134	2012-10-03 01:22:09	2003-04-07 12:59:11	10	8	111	3	20	153	2	197.90	45	33.31	CHANGED	VthLpAMpWINGDGY.HNVaVRa.sG-lhRPKTWhWQDV+TRKlLuhRsDhSENhDoIRLShhDVloRYGlPc..HlTIDNTRuAANKhhTGGs.NRYRapVpEs-spGlh.hhGhchHWTSl.hGKGhGQAKPlERAFuhGGLt-YVDKH.hLtGAYsGsNs.tKPD....Nhu-psVDhthFLhsLtpGlt.aNshssR.TEhCuGK.Sas-sFER-aA	..............................pLcAhphlNGDGapasVFV..+..W....s.G..c....l..l..RPKsah...WQDltoRKILuaRsDhSE.Nt-.olR.LuhhDl.......l..pp......Y..G.IPc..+lpIDNsRu.sAsKhhTG.Gs.............NRaR..........F...K.V+...-.-...-spGlh..hl.G.h...c.hHWTo..l....h...hs.cGhGQAKPlERAF.u..hsu..Lt-hlDK.+.PthsGAYTGsss.uKP-.....Nhu.c..+ulsh-hFlts..ltptlthaNs+ssRpoEhCtG..h.SacpsFptpY..............................................	0	8	14	18
+3434	PF03888	MucB_RseB	MucB_ResB; 	MucB/RseB family	Bateman A, Finn RD	anon	COG3026	Family	Members of this family are regulators of the anti-sigma E protein  RseD.	29.00	29.00	29.10	29.30	28.40	28.80	hmmbuild  --amino -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.68	0.70	-5.38	8	1077	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	1056	12	197	621	90	281.60	46	88.58	CHANGED	Lp+MscAsppLSYEloFVhp+suSh-ohRYRH.scp.DG+shA+LlpLDGstpEVlpRDsclSYhpPulpsFTlc.ss.lssshP.lhpsDhc+LSsaYDFlpVG+uRVAGRhssVlRllPKDsaRYuYllalDcEopLsL+SDLLDR-GpLLEQFRslsLsluptlststctLpssshPt...llpsspsstpsshuWpssWLPpGFshhs.thpp.slo-c..l-SthYSDGLFsFSVaVpsscusslpDpps+pGspTlhSchl....GspElTVVG-lPhuTAcRIApSI+Fs	.................................LppMs.ASQsLNYElSF.lp.l.s.c.p.u..lESLRYRH..Ach..D.sc.sl.ApLlphDGPpREVlpRG..s.E.lSYFE..P...G...l-PFT.........ls....Gc..hIsDo....lP...ul..lh...............s..D...............hc.+L...u.....s..aYDF.lsl.G.R.sRlAsRhCpVIRlVs+Du.pR.Y.SYllWhDp-o+LPhRsDLL....DR.DG.E.sLEQ..FRl..lu.hs..V...s.....p.....c...l..u........s....s..h........p....s.L.s........K...s....sL.Ps..................lL...sl..P....s.....u......p..............p....s..c.........h.......s....Wps.sWLPpGFsplupsRR...............s............L........s...s...........h......-s...........h.....lE..SpLYSDGLFSFSV.V...s..t......s..s.......s...s...s...s...-...Q.h..lR.p....GRRT..lhopV+........sss..E..ITl..VGElPPpTAKRIAcsIcF.t......................................................	0	31	91	149
+3435	PF03108	DBD_Tnp_Mut	MuDR;	MuDR family transposase	Bateman A	anon	Pfam-B_271 (release 6.5)	Family	This region is found in plant proteins that are presumed to be the transposases for Mutator transposable elements [1,2]. These transposons contain two ORFs. The molecular function of this region is unknown.	21.80	21.80	21.80	21.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.18	0.72	-4.40	89	954	2012-10-02 23:28:20	2003-04-07 12:59:11	10	78	48	0	424	946	0	64.40	24	8.07	CHANGED	ssthtlGphFpst..pph+pulppaulppphphchh+oc.pp+htscCh....scs...CsW+lhAuptpc.sptapl	.....................hhhGthFssh..cch+pAl...pp.au.lpp.c.hp.ach.h+os..pp.+hps..cCh......tcs.....................Cs..W+l..pApphpt.pphatl....................	0	13	155	219
+3436	PF04310	MukB		MukB N-terminal	Mifsud W	anon	COG3096	Family	This family represents the N-terminal region of MukB, one of a group of bacterial proteins essential for the movement of nucleoids from mid-cell towards the cell quarters (i.e. chromosome partitioning).  The structure of the N-terminal domain consists of an antiparallel six-stranded beta sheet surrounded by one helix on one side and by five helices on the other side [1]. It contains an exposed Walker A loop in an unexpected helix-loop-helix motif (in other proteins, Walker A motifs generally adopt a P loop conformation as part of a strand-loop-helix motif embedded in a conserved topology of alternating helices and (parallel) beta strands)[1].	23.00	23.00	23.10	23.10	22.50	22.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.58	0.70	-5.02	2	745	2012-10-05 12:31:08	2003-04-07 12:59:11	7	2	733	6	73	491	11	224.10	84	15.54	CHANGED	MIERGKapSLThINWNGFFARTFDlDpLVTTLSGGNGAGKSTTMAAFlTALIPD.oLLHFRNTTEAGuopuSRDKGLaGKLpAGsCYuhLDslNSRpQRllhuV+LQQVAGRD+KVDIKPFhIQGLP.pVpPTpllsETls-+pARVh.lNElKDtltthEGspFKpFsSIsDYHu.MF-hGlIs++LRsuSDRSKFYRLIEASLYGGISSAITRSLRDYLLPpNuG	.......MIERGKFRSLTLINWNGFFA.RTFDL..DE...........L..............VT........TLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATS.GSRDKGLHGKL.....KA.G.VCYShLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPhSVQPTQLlTE.TLNERQARVLsL.NELKDK.LEsMEGVQFKQFNSITDYHSLMFDLGIIARRLRSA.SDRSKFYRLIEASLYGGISSAITRSLR.DYLLPENSG........................	0	7	23	49
+3437	PF04288	MukE		MukE-like family	Mifsud W	anon	COG3095	Family	Bacterial protein involved in chromosome partitioning, MukE	25.00	25.00	26.80	26.60	21.50	17.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.52	0.70	-5.56	3	756	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	742	12	72	290	5	226.30	80	96.59	CHANGED	MPsKLApAIANPLFPALDSLLRSGRHISoD-LDNHAFLMDFQs-L-tFYpRYNVELIRAPEGFFYLRPRSTTLIsRSVLSELDMLVGKVLCYLYLSPERLApEGIFTsQELYDELLTLADEuKLLKLVNNRSSGSDLDRQKLtEKVRoSLsRLRRLGMVhTlG-psSGKFRITESVFRFGADVRuGDDPREAQtRLIRDGEAs..TP-shslEsQtQLhENDTsEtDE.DoEa.GE-E	.........MPVKLAQALANPLFPALDStLRSGRHIGLDELDNHAFLMDFQEaLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPE.RLANEGIFTQQE.LYDELLTLADEuKLLKLVNNRST.G..S..D..lDRQKLQEKVRo....SLNRLRRLGMVWFMG.pDSSKFRITESVFRFGADVR...uGDDPREAQtR...LIRDGEA..........MslEN.c..LQL.......N..DEoE..E.s.Q...sDS...GEEE..............................................	0	7	22	48
+3438	PF00893	Multi_Drug_Res	DUF7; SMR;	Small Multidrug Resistance protein	Bateman A	anon	Pfam-B_1082 (release 3.0)	Family	This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide ([1] and quaternary ammonium compounds [2], through coupling with proton influx [3].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.02	0.72	-3.52	17	6822	2012-10-02 19:55:49	2003-04-07 12:59:11	14	6	2594	2	1186	4014	2383	92.70	32	83.38	CHANGED	hsal...hLhlAhlhEllusshLK........ocGFo+hhPolhsll...uauluFhhLohuhcp.lPlulAYAlWoGlGhlhsslsullhFtEplshhpllulsLl	................................................................tWl...hLhlAhl.hElh...ushs...L...Kh...........................o.p..G..F..s..+....h...h.....s...s..l...l..s...ls...........sh..sl.S.F...h...h...L..u.h..Ah.+p....l..P..l....G...lAY...AlWs.Gl.Gh...l.ss.slh...uh...l.las-slshhpllulsLl.........................	0	303	684	942
+3439	PF01225	Mur_ligase	FPGS; 	Mur ligase family, catalytic domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188),  MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan.  Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide.  The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine.  The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.62	0.72	-3.91	236	13732	2012-10-10 17:06:42	2003-04-07 12:59:11	20	28	4352	28	3015	10183	5325	86.30	23	18.21	CHANGED	plp.hlulsupshs....shu.hhlshtGhpl...............sGpDhhpp......hhptG.Atshlsc....pst.............................t.th..tspt.tl.l..sttphLuplspthh	.....................lphlslcup..t.hs........shs..la.l.s..h.h.G..t.ps...............sGpD...hhsp........................hhp.pG....ss....shl.sp......cst...........................................................................th...t....s..p..h..s..t.l..V....hs.t.tphLuplst.h.h.............................................................................	1	1033	2013	2574
+3440	PF02875	Mur_ligase_C	FPGS; 	Mur ligase family, glutamate ligase domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188),  MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan.  Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide.  The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine.  The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.13	0.72	-3.95	50	21443	2009-09-14 13:20:23	2003-04-07 12:59:11	16	65	4466	65	4592	15708	6742	85.40	20	18.16	CHANGED	lt.tRh-hlsp..........pshhllsD.YAHsPsuhpsslpshtth...............t+llhlhGsht-...Rstshps.hspltsthssh.lllhs....t.tp.ststh	..........................tRhp..h..l.s.p.............................p.s...s..p.l..lsD..aAHsPsuhps.s.l.puh..p..t.h..s.....................................pt+.ll.hlhG.shhc...................+....s...t.s....h....t.t...h.s.p..h.h.s...t.....ss....llh..h..t..................h.............................................................	0	1552	3028	3916
+3441	PF02873	MurB_C		UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1092 (release 5.2)	Domain	Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.	21.00	21.00	21.30	21.20	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.28	0.72	-4.28	13	4494	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	4271	10	953	3207	1942	113.70	37	35.04	CHANGED	cpplhppspphpppR.h.ppPhchPsu..GShF+NP.sp..............................tAGpLIEcsGL.KGapIGGAp...lSchHANFllNpGsAoucDVlsLIchV+ppVt-caGlhLc.EV+hIG	...........................t..plhpthpclppp+....h...p..P..h....p..h..s..os..GShF.K.NPhsp...........................................................hAGhLI-p.u.GL.KG....h....p.....l.......GG....At.................VSp..+..HAhhllN...t..u......s.......A......Tup........D.......lhsLhctVpppVt-+FGlpLcsEV+hlG..................	0	325	632	810
+3442	PF02976	MutH		DNA mismatch repair enzyme MutH	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.90	21.90	23.00	22.30	20.70	21.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.34	0.72	-4.15	50	953	2012-10-11 20:44:43	2003-04-07 12:59:11	10	5	911	6	127	531	32	101.00	60	39.83	CHANGED	h.LGAsAGS+PcQDF..scLGlELKTIPIstpGc.............PLETTaVslAPLhshsGl.sWcs.SpVpcKLp+VLWlPlpG-RpIPl......u-RpIGsslLWpPss.p..ppphL+pD	.................hLGAoAGSKPEQDF.......AtLGVELKTIP.lcuhG+.....................PLETTFVCV.APL...TGNoGV.TWEo.SHVRHK..Lp..R..VLWlPVEGER...sIPL............AcR...RV...GoPLLWSPsc...E....E-cQLRpD...................................	0	19	53	92
+3443	PF01624	MutS_I	MutS;MutS_N;	MutS domain I	Bashton M, Bateman A, Studholme, DJ	anon	Pfam-B_800 (release 4.1)	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.30	0.71	-4.04	60	5408	2009-09-12 04:05:03	2003-04-07 12:59:11	15	62	4333	49	1586	4546	1040	110.20	40	13.01	CHANGED	TPhhpQYhclKpp.a.DslLhF+hGDFYEhFh-DAhhuu+hLslsLTt+t........tstsp..hPMsGlPh+uhcpYlp+Llp.p.Ga+VAlsEQhEsstts.................+.....s...llcRcVs+llTPGTlh-ss	...................TPhMpQY.hclK....tp.....a.s..........D..slLhaR..h...G....D...FY.E...........hF..........a.....-......D........A.......h......p........A.uplL-IoLTpRs................tsssp....lPMsGlP.a..Hu.......h.-sYlsc..Llp.p..Gh+V.AI..sEQ.h.p-.Ptps......................................K......G......VcRcVscllTPGTlh-t.s...........................................	0	529	978	1330
+3444	PF05188	MutS_II		MutS domain II	Studholme, DJ	anon	Pfam-B_800 (release 4.1)	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein [2].  This domain corresponds to domain II in Thermus aquaticus MutS as characterised in [4], and has similarity resembles RNAse-H-like domains (see Pfam:PF00075).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.77	0.71	-4.11	47	4968	2009-09-11 06:26:47	2003-04-07 12:59:11	12	45	3989	50	1597	4177	853	129.10	23	14.77	CHANGED	shlsu...lht.........cssp.hGluhlDlooGchhlscht.-....hpcLhscltp...lsPpElllspsh.p....................hphh.thphh.....s....ht.hphpp....s..ppplp..pta......sspslcshs........t..thsls.AhusL.....lp......Ylcpsppp.......tlsplp	.................................................NhLsu....lhp................pppt..hGlAhlDl.oo.Gca..h....ls..p..hs.s............hppl.ts-ltp..........lsPpEllh.sc...s.hsp...............................................h..h..p...h...h.....t.......t....h..p.h.h.................t................hp...h..p..h...ps.................s......p..pplp......ppa.....................ts..p..slps.hsh.....................................pt.hthsls...As.usL.....Lp..............Ylcc.TQpp........pls+l...............................................................................................	1	504	952	1325
+3445	PF05192	MutS_III		MutS domain III	Studholme, DJ	anon	Prosite	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterised in [4].   	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  --amino -o /dev/null --hand HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.54	0.71	-4.54	306	6533	2009-09-15 09:54:17	2003-04-07 12:59:11	13	68	4115	50	2168	5633	1219	291.10	24	33.92	CHANGED	ssThpsLElh.......ps................tstpps..........oLhsll.cc.shTshGpRLL+p..a.ltpPLpc.hspIppRhcsVpthh....p............t............t..ppl......pptL....c.pl..s.Dl-Rll....sR.........................l..............................th..........sps.........s...........s+-lht.....ltpul....pth.p.l..............................................................tph.......htt............................................ltphhp..pls................plh.......phlppslsp..p............sh.h.................................................pcG.......t........................hl....tsGhsscLDph+phtppscphltphppc.ppptshsslchthspshsh.....................................................hhpsppsttpphstpahpppshtss.Rahos-Lpchppclhpsppcthth-pplhppLhpp.h.hsp..hstl.ppsspslApLDsLhuhAc	.......................................................................ohpsLElh................psh...................tstpps................oLh..tlL...Dc..otT.s.h.G...............s........RhL......+p.......W..lp.............pPl...h..s...hp.p.I.......pp..R..ps....lp..thh................p...............t...hp........ppl..........................p.p..hL.........................c..pl....h...Dl.ERll..........uR......................................................................l..................................................................sh........................sps.........................s....................................s+DLh.p...........lp.pul..............ptlsp.l..............................................................................................pph.............t.hps......................................................hlpplhp.........pls...s...............htclt.................phl..ppu.lsc....p..................sshhh..................................................................................p-Gs............lI..tsuhstpLDch+phtppspphltphptpccppsulpsl+ltaspshua.........................................................................................................................................................................................................hhphppsttphsstpah++pThtsspRahssELpch-sclhpucpcththEtpl.a.pplhppl.h.....tp......h.....pt.....l...pphup...sl.ApL.DsLhuhA.......................................................................................................................................................................................................................................................................................................................................................................................................................	0	758	1352	1838
+3446	PF05190	MutS_IV		MutS family domain IV	Studholme, DJ	anon	Members of PF01624	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds in part with globular domain IV,  which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.87	0.72	-3.81	51	5085	2009-01-15 18:05:59	2003-04-07 12:59:11	13	40	4000	48	1596	4267	904	92.30	34	10.61	CHANGED	uasscLDch+phhcpspphltchppct+c..chGl...psLK...lshsphhGYalclocsp....tppl....Pt....pahc..ppT..hKsutR...atTscLpphppclhpscpc	.....................GastcLDchRphtcsu.ppa..l..t...c...lct+ERc.........coGl................poLK.....l..s.a.N...p.....V...a..G..YaI-..l..ocup..............tppl......Pt.......cahR.....+QT...Lp..NuER.................ahT..sELKchEcclLsAcp.t....................................	1	515	946	1314
+3447	PF00488	MutS_V	mutS;MutS_C;	MutS domain V	Finn RD, Studholme, DJ	anon	Prosite	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of  Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.56	0.70	-4.96	35	9697	2012-10-05 12:31:08	2003-04-07 12:59:11	16	85	4461	50	2841	8224	1959	222.30	35	28.75	CHANGED	YsRPphscp.............slpIctGRHPVVEphh...sttsFlsNDspLspsp........phhlITGPNMuGKSTYlRQsALIslhAQlGSFVPAcpAcIullDpIFTRlGAuDcLspGpSTFMVEMhETAsIL+sATccSLVllDElGRGTSTaDGlulAaAlsEaLt..cch+uhTLFATHY+ELTpLspp.....hss.........Vp..NhHhssh..........Eps.pslsFLapl.ppGsus.cSYGlpVAcLAGl.PpsVlpcA+phLppLEpp	................................................................................spPp.h...s...p..pt..............tl.pl.p..puR..HP..l..l....-p..h......................................h.....l....s.N..s....l.p....l...s...p..p.p...................................phh.l...IT...........G.....P.......Nhu...G.K...S.Ta........hR.................p...............luL..................lslh........A.Q...h.....G..s.a..V.P..A....c............p......u.......p..l.....s.l.h.........D.p..I.F...o....R..l............G..s...........s....D.........s......l....t.......p....G.....tSTF..........h.............sE.......Mp..c........hs............p.I...L........p..........p.........A...............o..........p................p.............S............L...l..L..hDE.......lG........+.GT.soh..DG.h....ul.Ah.A.ll-h.lt................p.......p...h.......p....s....h.s.lh.u.T.HY.h..E..L...s..p.......h...s....p...p......h..t...t.................l.t.....N...h.p.h..p...h...........................................p..s....ppl...h.....a.....h....a...cl......h.......G....s.s.s......c.S..a.....ul.plAp.hh..G..l......Pppllp.....cApphht.....t...........................................................................	0	1046	1858	2452
+3448	PF03023	MVIN		MviN-like protein	Griffiths-Jones SR, Studholme DJ	anon	Pfam-B_1348 (release 6.4)	Family	Deletion of the mviN virulence gene in Salmonella enterica serovar. Typhimurium greatly reduces virulence in a mouse model of typhoid-like disease [1]. Open reading frames encoding homologues of MviN have since been identified in a variety of bacteria [2], including pathogens and non-pathogens and plant-symbionts.  In the nitrogen-fixing symbiont Rhizobium tropici, mviN is required for motility. The MviM protein is predicted to be membrane-associated.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.45	0.70	-6.07	15	3361	2012-10-02 21:24:20	2003-04-07 12:59:11	9	10	2911	0	898	5047	4017	445.50	29	80.32	CHANGED	lAshhGAushuDuFhlAF+lPNhlR+lhu..EGuhssAFlPlasctp.........stccuptFspplhslltsshlllollh.llsu.hlltlhusGh.........st-shpLssthhplhhPalhhluLsulhsulLNstc+FhssuhoPllhNlshIhslllhtsphs...hh..........u...LulGlllGGlhQhLhplsslt+tGht.................hc.hhshp-psl+cllphhhssllusulsQlsLhlsptlASh......lpsGuhuhltYusRlapLPlGlFululuTllLPplS+shtsp-ts......phtphhspul+lshhlhlPsohulhlLutsIlslLap+GsFstp-sttsuplLtsaulGLlsauLhplLtpsFYApc-s+oPhplullshllNhshs.....llhhsshussGlAlAsuluuhhshshLahhlt+phh........hh.ttththhltp..hlsshulhusllhhlpphhp..asssphhhhhht	............................................................................................................................................................................hAthhGA..G..h..s.sDAF.h.lAh+lPNhl.R.c.l..hA..EG..A..F.u.p.A...FV.P..l....hschp..p...........................pspc.t..spt...a....s...sp..l...h...s..h.l.s...h..h.l.h.l....l.T...l.l.u...h.l...huP...hl.....l.h....l...h.u.s.Ga..........................sspp..h..s.Ls....st....hh+.I.h.h.P.a....l.h..hl.u.Ls.u..lh.u...u....l.....L....N....s.h....s...+....F....u.h..s..A...a...u..P....l.....l.....h.N.....l.....s.....h....I.....s....s.....h...l......h.....h...s....s....h....h....s...........s.hh.........................u.........L.A.h...u.l...h...l.G...G...l.....l....Q....h...l...h...p...l.......s....h.L...p.+..h...G.hh.............................................ht.s...c...h...s....h....p......c...s........s......l....p....+........l........h.....p....h.....h....h.....P.....u....l........l...u.....s.......u..l....s......Q.....l..........s.....l........l........l....s.....o.......h........l......A.S.h................................L..s.s.....G....u.....l....S..........h..........h.......h..........Y......A.....s......R..........L..........h........p.....h..........P........h........G..........l........l....G..l....A....lu.T....l..l....L.....P.p.L.S+.t...h.ss.s.s.ps......................p.hpph.hshul+hshlls.lPuulul....h...lLu.........tPlst.sL.....F..p......h.............G..p.....F...s...s...t....D...s.....t..h.s.u...t.u...L.h.s..Y..u.l....G...L...l.u...h.h....l.h.+...l....L.s...uF...Y......A...+.p.D...s.+..T....P.l.t....l....u..l...l...s...l.l.l.sh..l.hs.......................lhh..h......h.........h..........t.......h......s....G.......L....u.....l...u..t....u....l....u....u....h....l.s...s..s...l....L....h.h...h..L..p..+.p..hh....................h.t..s..t......t..h...h.h..h.hhp........l.hlu.s...h.l.h..u....s.s....l....h.h.h.......h.....................hh........................................................................................................................................	0	310	608	772
+3449	PF02344	Myc-LZ		Myc leucine zipper domain	Bashton M, Bateman A	anon	Pfam-B_829 (release 5.2)	Family	This family consists of the leucine zipper dimerisation domain found in both cellular c-Myc proto-oncogenes and viral v-Myc oncogenes.  Dimerisation via the leucine zipper motif with other basic helix-loop-helix-leucine zipper (b/HLH/lz) proteins such as  Max Swiss:P25912 is required for efficient DNA binding.  The Myc-Max dimer is a transactivating complex activating expression of growth related genes promoting cell proliferation. The dimerisation is facilitated via interdigitating leucine residues  every 7th position of the alpha helix.  Like charge repulsion of  adjacent residues in this region perturbs the formation of homodimers  with heterodimers being promoted by opposing charge attractions.	20.50	20.50	21.30	21.20	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.22	0.72	-7.47	0.72	-4.32	2	981	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	838	4	26	560	0	27.60	84	13.20	CHANGED	u-Ep+LIuEK-.LR+RREQLKHKLEQLRNSpt	.SDEHRLIAEKEQLRRRREQLKpKLpQL.......	0	2	5	9
+3450	PF01056	Myc_N	Myc_N_term; 	Myc amino-terminal region	Finn RD, Bateman A	anon	Pfam-B_387 (release 3.0)	Family	The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see Pfam:PF00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication [2]. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest [3].	22.20	22.20	22.40	22.30	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.43	0.70	-5.27	9	1946	2009-12-11 14:44:54	2003-04-07 12:59:11	13	10	1164	2	129	1419	1	143.50	44	69.28	CHANGED	MPlsuShssKNYDYDYDSlQPYFYhDp-D.sFYa..pQps.phQPPAPSEDIWKKFELLPTPPLSPSRRsSLu........................TA-QLEMVoEhLG........sDsVNQSFICD.ushupoFlKSIIIQDCMWSGFSAAAKLEKsVSE+LAShpAuRKEsshusss......................uussRhsusYLQDLusuASECIDPSVVFPYPLs-su........pss............sAsP..............psh.shcssPs....uSSSSGsDo..........-pp---EEEp-EEEEIDVVTVEK..ppp+pcsssSto..............ta.SPLVLKRCHVshH.QHNYAA..PST+.cDtPusKRl+LEup..spslpth.s.....pRKCsSP	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...p.pp......t....s..........................s+s.tSPL..V.LKRC..H.Vs.hH..Q.HNYAAP.......P.S.T+.....h-....Y...P..u....uKRh+L-u.............uRVLKQISs.........sRKCsSP..........................................................................................	1	13	28	56
+3451	PF01669	Myelin_MBP		Myelin basic protein	Bateman A	anon	Pfam-B_1868 (release 4.1)	Family	\N	22.00	22.00	33.60	26.40	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.84	0.71	-3.87	5	142	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	42	9	32	174	0	115.40	55	72.19	CHANGED	MASASTSDHARHGhGs..RHRDSGLLDSLGRFFG..GDR+VPRKGpGKs...shtttl..hPp.+tttttst...s-ssVVHFF+shhoP...ss.ptthpthu..ho.................h.p.pppuh+u+K....-GpGs.....chG......tptpuSP.SRR	................hAoASThDHARHGahs..RHRDoGlLDSlGRFFG..GDRs...sP+RGSGKss............sRssHhGSLPQ.+s...pH.uRst...D-NPVVHFFKNI.VoP+...........sPPspu+utth.......t........................................................................................................................................................................................................................	0	1	2	10
+3452	PF01275	Myelin_PLP		Myelin proteolipid protein (PLP or lipophilin)	Finn RD, Bateman A	anon	Prosite	Family	\N	20.40	20.40	20.40	23.30	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.79	0.70	-5.03	7	395	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	126	1	135	334	0	203.20	47	86.95	CHANGED	GCaECCI+CLGGVPYASLlATlLCFsGVALFCGCGHEALoGTEpllEpYFS..pNhpDahhLhsVIphFQYVIYGlASFFFLYGILLLAEGFYTToAVKplaGEFK..........TTsCG....................RClS......shFlhlTYlLslsWLuVFAFSAlP...VaIYaNhWoTCQsls.ssps.ssshtplCsDsRQYGllPWNA.PGKlCG...sLtsICpTsEFphTaHLFIsAhAGAuATllALlpYhhusoaNaAVLKhhuRtst.p+h	.................................Ghh-CCh+CL...sul...PaASLlATlLha.GVALFCGC.GH.ALouT.tllc.paFp......psh.t.Dh....lhph.Iphhp.YV..IYG.lAuhFFl.YG.llLL.sEGFaT..T.u.Al..+.c.l.a.G-.aK..........sThC.G................................R.Clo.......................................u.hFlhlTYlhhlsWLhV.huFoulP...Va.haa.NhWo.hCpshp.spts.............plChDh...............RQa...G..ll..P..h...s....s......s....h..K...............l.C.ss...........sh...phCpo..sE.h..ho....acLFIsAhsGA.u..hsl.luh...............lp...ahhhhohNaAhl+.hs+.pt...............................	2	31	42	79
+3453	PF00063	Myosin_head	myosin_head; 	Myosin head (motor domain)	Sonnhammer ELL	anon	Blastp MYSA_HUMAN/1-840	Domain	\N	19.10	19.10	19.20	19.10	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	689	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.23	0.70	-6.49	24	7667	2012-10-05 12:31:08	2003-04-07 12:59:11	16	484	1348	171	3682	6883	268	481.40	32	44.72	CHANGED	s-DhstLohlsEsulLcNL+pRYt.sshIYTYsGhhLlulNPa+pls.lYopchlptYcG+p............+tEhsPHlaAlA-pAYRsMhs-pcsQsllloGESGAGKTEsoKhlhpYlAuluussst..................................................p.tplcpplLpuNPlLEAFGNAKTsRNNNSSRFGKalcIpFstsGph....sGupIpsYLLEKSRV...lhQspuERNaHIFYQLLuGsssp..+ccLpLs...............sspsYtaLspsu....shsl.........................sGlDDsp-FptsppAhcllGhocp-ppsla+llAulL+lGNlp.Ftpst.....ppptu.............csppt.hpthutLhGlsstshtpuLhp.plpsG........pphlsps.shppAhhu+DALAKulYuRLFsWlVs+lNpsLstpp......................................ppsthIGlLDIhGFEIF..-hNSFEQlCINasNEKLQQhFscphhphEQEEYh+EGIpWshI-a.hDspssl-.LIEp...PhGIlulLDEpshhP+u....oDpoFhpKLhppa.spps...pa.p+s.c..........tspspFtlpHYAGcVpYsspual-KN+DsLpssllslhpsSps.sllsplFpp.p..............................................................tttpttpspptph.pTsutpa+pslspLMpsLpss...sPHalRCI+PNcpKtsspa-sphVhpQlpssGlLE..slRlpRtGFssRhhascFhpRYplLsspsh............tsscpusctlLppl......sh-...tppaphGpTKlFh+	......................................................................................................................................p...t.........h.....l...Ra.....................................h.....a................o...............u...........h.h.ls.hNP....h..t...h.......................t..........t.............h.......t.......................................................t............P...Hh..ashs..p.s.a.............h..................h................................................t.....................s.....Q.....s..h.l................h................o......G.......E.......SGuGK..T..........s...........s.K.......h..l...h.p.....a..h.....ut...l.u...s.......tt......................................................................................................................................................................................................................tplc.p..p..l...........l....tu............NP..lL..E.....A.FG...............N.AKTh+N.s...N.............S.............SR...F..............G....K.a.l.c.........l...p..F.....s.......p.G.t.l...................................uu..p.l..p...............p...........Y...............L.L...E........K.S.........Rl...................shQ............t.s.E......Rs.aH........lFYp..l.h..s.s....t....p.................p..............hp..h.h.l.t............................................ss..p.a..tal.sp....s......................ph.p.l............................................................................................................s...h...s.....D....t....p......p.....h............t.......h......................p.......A....h....p.hl.G.hs.........p...c................................sl.hplhu...u...l.....h.+...h..GN...hp....Fpttt..................t.t...p..ts..............................................................sp...p...........hp.....hs.....u..........Lh..sl.....s...........t...p.....l....ps.....l....hp..ph.hst..............................................t-h.l...p...s..s...h.t.p.......s..................sh..s...uh...uKslY.t..p.hF..a...............h........l.......t...lN..t....h....................................................................................................lu..l..L....Dh....h.G..F.E.h.....................t.N...............s...h...E..Q..h..h..lN..hs.........s.E..p..............LQ........t......a..p...................h............hh...-........p.........p...................................Y.....t....E..........t.....l................h.........................................l......p..a...............s..................t...............h.h.................p.........l.......l.............tt.............................................................u..............l...h..hl..p-ts...h...t.s...............sp...t...hh.t....p.h...t.........t...tt...................h.................................................tF.l...H......a..u.s..........V.......Y.p....h..........t....h...h.....+...N...-.....h...........p.h....th..h...............t.........u......t.......................hh.......h.h...................................................................................................................................................................................................................................................................................sh..s....h...p.........p.h....L..h.t..l...tt.................ts.al+C..............l..............h......s...................N...........................................................................................................................h............p.............hhtQlp...t.hhp....hp..h..t...........u.a................s......p.......h.......hh..............a...........h......................................................................................................................................................................................................................................................................................................	0	1142	1634	2706
+3454	PF01576	Myosin_tail_1	Myosin_tail; 	Myosin tail	Bashton M, Bateman A	anon	Pfam-B_356 (release 4.1)	Family	The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types [1]. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then  assemble into the macromolecular thick filament [1]. The coiled-coil region provides the structural backbone the thick filament [1]. 	51.00	51.00	51.20	51.00	50.90	50.80	hmmbuild  -o /dev/null HMM SEED	859	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.14	0.70	-13.91	0.70	-6.82	15	2444	2009-01-15 18:05:59	2003-04-07 12:59:11	14	63	325	2	1048	2212	11	548.10	35	44.88	CHANGED	-hEpp+c-lEpsLp+KEuElstlss+lE-EQshltpLQ+pl+-LpuRIcELEE-LEsERsARsKuE+pRuDLucELEELuERL-EuuGATuAQhELNKKREAELsKLRRDLEEuslpaEsslusLRKKHsDAlsElu-Ql-QLQKsKuKhEK-KuphptEl--ltupl-phsKuKtssEKhsKphEsQlsELpsKhDEhsRpls-lsopKuRLssENu-LsRQlEEtEsplssLo+hKupLsuQLE-A+RsLEEEuRpRssLpupl+slppDhDsLREplEEEsEAKu-LpRQLSKANuElpQW+oKaEsEuht+sEElEEhK+Khpt+lsEhE-plEutpsKsssLEKsKsRLpuElEDLpl-lE+usutsupLEKKQ+sFDKlluEh+pKs--lpsEL-sAQ+-uRshSoELa+LKsph-EstDplEuL+RENKsLuDEl+DLs-pLuEGGRslHELEKs+RRLEhE+-ELQuAL-EAEuALEpEEsKshRuQlElsQlRsEhERRLpEKEEEhEspRKNppRsl-SlpAoL.EuEsKuKuEshRlKKKLEuDINELElsLDtAN+usA-tpKslK+hQpQl+-LQpplE-pQRp+--scEphthAERRsssLpuElEELRssLEpuERuRKtAEsElsEAs-RlsELsuQssoLsupKRKLEu-lsslQuDLDEshsEh+sA-ERu+KAhsDAs+LA-ELRpEQ-pop+lE+hRKsLEpplKELQsRL-EAEusAlKGGKKhIpKLEsRVRELEsELDuEpRRptEspKshRKt-R+lKELphQsEED+KNh-+hQDLlDKLQtKlKsaKRQlEEAEElAshNhsKaRKhQ+ELE-AEERADpAEpsls+lR...uKuRs	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...................................h.....h.............ph...p.p.p.............t....t........++...p......phtt...t.t.t.......th..c+.t........p.h..-hpsh............hp...t...t.......h.pp.p....p...hp..p...........tp.p..........t..p.......h...pt.....tp.p.h....sch.t....httth....p.p............th.t..t.......hp.......p.........t.h.t.......t.......cht..p...h........................tt...tt.tt.p..h.tphpt.hpthp........ph......c.p.t.......hc-..ts.......thp.............c.......tt..............h.Rhphp.h.....t.th+tphpc.ch.t...t+-.-p.-t....h..+.p.t..t....h..cp.hp.tL..-..t..Ehc.......+..t.h.t.+...cchc.plt...............p.h..p.....thp.tts..p.............t.........-...........+p....h....c..............p................p.............h...p....................-....h...............hth...--t........t........pchht.p..t..pcc....t.hts-h.p.............hp...htts.+t.++.h.......c.-h...............-..httph.......t.........tt.......t....t....s....s.......h.........p...tt....pp....h-tcl.plpt-h--..pp.p.h.-+hc+s...p..h.t........h.t.....p-Ltt.Ep.......p..tttc..E.p.+pphEtp..............K-.Lp.+Lp-..hEt.s..hp...t........h.+.t....lttLEs.+.................l....tpLE..tpl-tEp....+..............ct....ts.+thR+h-++...lKEl..h.Q.s........-..........-..-++p..p.h.p-.h-Khp.+lK.....thK.RQ.h-Eu................Ep.sp...s..ph.R+hQ+EL--tpEts.-...hppplpth+.....................................................	0	216	306	674
+3455	PF00819	Myotoxins		Myotoxin	Bateman A	anon	Pfam-B_1337 (release 2.1)	Family	\N	25.00	25.00	80.40	80.30	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.44	0.72	-3.90	2	29	2009-09-10 20:59:54	2003-04-07 12:59:11	12	1	8	2	0	31	0	41.80	88	77.46	CHANGED	YKRCHhKtGHCFPKphIClPPSSDFGKMDC.W+hKCCKKGSsp	YKpCHKKGGHCFPKEK.IClPPSSDFGKMDCRW+WKCCKKGSsp..	0	0	0	0
+3456	PF02384	N6_Mtase		N-6 DNA Methylase	Bashton M, Bateman A, Mian N	anon	Pfam-B_508 (release 5.2)	Family	Restriction-modification (R-M) systems protect a bacterial  cell against invasion of foreign DNA by endonucleolytic  cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (Pfam:PF01420), and R [4]. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.90	0.70	-5.35	15	7778	2012-10-10 17:06:42	2003-04-07 12:59:11	11	73	3514	13	1474	8902	2092	276.20	22	51.07	CHANGED	pstDlhGDsYEYlLupFApspGKpuGEFaTPpsVocLlsclL....-spssc.IYDPAsGSGuhLlpsp+altt........sspspslsla....GQEhstoTapLA+MNhhlHsIchstht...lphuDTLtsspap........-tphDhVlANPPast+.W........ssssltsDs..Rap.t.....hsPpssA-aA..al.HhlhpLussG+AAlVlssGsLac.GusEucIR+tll-pshl-slIuLPspLFas.TuIPsslllLsKsKs.........pcscVLFIDAsp.atpcs..+ppstLos-cIpKIs-sapph.....................c-ls.....tFu+sAol-EIpcNDYNLslsRYVsstcpc--	........................................................................................................................................p...p.huph...Y.E..h..h.lt.............p.............h................................t....t.............s.............p..........p..s..Gpa..a..T.P.p.t.l...s.c..h.h.s....pll.........................................p.s...p.......t...t.....p....l.....h.....DPs.sGoG..u..h....L....h.p...s....h....p....h...l............................................................t.p.........t...p...h.....p.h.a..................G......E...h.....s...............t.......s...h.....t.........l.....u.......t............h.....N........h........h.......l........+.....s......l........p...........t...............t....................lh......s...s.....o......L..p...p..s.hh....................................................tph..D...hl..luN.P..P.a....u..h..p..................................tt..p..p..h.......t..p......s....................h.................................hs.s.p...s.....p...s....p....h..h..............F....l...t.....p.....h.....l.....p...h..........L..............p..........s...............s..........G.........p......h......u...l.l...l.s.p....u..h.L.hp....s..........s......t......p......t....p...............l....R..p...h.l.l..........c........p.......s.........................l.c..s.....l.............l...t......L.........P...........s.......s...l...F.......h...s.....s..s......l...s...s..s..l..h...h..h.p....K.p.p.........................................tpp..p.l..h..h.......h..c..h...t....t............h....................................tt........t.p....h.........t...............................t..............p.........h.............h.........t.h..h.t...........................................................................................................................................t........................................................................................................................................................................	0	495	1021	1282
+3457	PF01555	N6_N4_Mtase		DNA methylase	Bateman A	anon	Pfam-B_164 (release 4.0)	Family	Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.58	0.70	-4.87	49	7047	2012-10-10 17:06:42	2003-04-07 12:59:11	13	54	2966	14	1466	6738	4026	224.00	20	60.70	CHANGED	lcllhssPPYshspp........................................thsptps..........hppahpa.....hhphlppstcl.........LKssGslhl.ss.phht............................................................................hhthhhp.hs..ahhhshIhWpKs........t.shsp.pt..............phstspEhllh................asKscph....................................................hhshphhch.hpptpthphtt........................................h...........W......................................................................................................ht..ppppt..............H......ssp+PhtLhc+lI.phsop.........sDlVLDPF....hGS.......GTTshsAtpLsRp.......................aIG.hEhppcahc..hutc	.....................................................................................................................................................................................................................lchlhhDPPY..ht.p.................................................................................................t.t.......p...............................p..ta....h.p..h............h.......h..ht..hhcl.............L.p...s.G.s.h.hl....hs...pth.........................................................................................hhhh.h...p.............s................h..h....s.......l.h..Wppt............................................hsp....t........................................................................hh.t.....t...t..E..l...hh.................................................................................h.....Ks.tt..............................................................................................................................................................................................................................................................................h..........................W.....................................................................................................................................................................................h......t..............................................a..........s..s...KP.t...L....lppl.I....t..h....s..o..p................................................s..s...l...V...L.DsF....sGS.......GTTsh......s...uh..p.h.s..R.p................................................hlu.h-.hptthhp.....t...........................................................................................................................................................................................................	0	537	1019	1270
+3458	PF04245	NA37		37-kD nucleoid-associated bacterial protein	Mifsud W	anon	COG3081	Family	\N	24.60	24.60	25.60	24.90	23.10	23.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.20	0.70	-5.10	105	1727	2010-01-13 16:22:14	2003-04-07 12:59:11	8	1	1574	0	252	1017	43	316.50	30	96.20	CHANGED	llHplsppsp........................phhhpsp.h.h..ssphp....t..hltchhpth..spc.sttsauph.........................t..thsttlpphhp...t........ppsFhphSpphuppLh.pphpc.p...hs....uGpllhspa...........p..t....sp.........hlhlhhlcpcpuhhhspp............lchp.p.ptl.........sls+lphuAhIslsph..............................phhlshlcscsscp......sstaatc.FLuspp.thsspppocshlpslccaspst.......lspppp.p.....ph+pplhsahpc.......s.-..plslpcluspl..................t.p.....th..sFt....pahppp..th.plp......ps..Fssspsslcph.t+h..sspstulslphctphhs....p.....phh..s.pss-.s....l..pIps..h.s.hpcplpc	..........................................................lHQl.pccp..........clhLp-phL.s...spplp.....p.hltcltchh....ssc.p.psauha........................ps...hsph.L.p.hhp....s...............pcDFlth.SpshsppLp.-.............th..sc.s........hs....uG.llFspa........................phhu..s-................................aLhlhhls.ppohphsps........l-ls.s.phL....................sls+hDhsAcIsLoph..............................spalsalcsR.ls+c.......ls.Fh..hc..FLuss..slssKtps+s.Lhpssc-...astpt.....ph-ctpp..p.......pl+pp...lasahpE.......u.-....El...pl...c.pLup-Lh..............ss..........ps...sFh.....-aspEp........th..tlp....Es..hs.s.D....+..p.s.lcph..pKa.....sutusGlslsh.ss..lhs-........chh...s..ssD.T..........l......hIKs...h...h...................................................	0	62	131	201
+3459	PF01235	Na_Ala_symp		Sodium:alanine symporter family	Finn RD, Bateman A	anon	Prosite	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.50	0.70	-5.90	6	5556	2012-10-03 01:44:59	2003-04-07 12:59:11	12	8	2931	0	865	4003	1762	405.60	38	87.29	CHANGED	hhchhp....hhu++scuG..sloSFQALsTuLAuRVGoGNluGVAhAIuhGGPGAVFWMWVsAFlGMATuFsEsTLAphYKh+Dp-GshpGGPtYYlp+GLuhRWLullFAlh.llloFGhlhsulQsNuIAcAhssuFshsslVTGIlLsllsuLlIhGGlKRIAtlophlVPhMAllYllsALsIlhhNI-plPsVIttIhcSAFuhptAsGGhlGusl..AhhhGlpRGLFSNEAGhGSAPpAAAAAcsp..HPspQGlVQhlGlFlDThIlCTsTAllILLoG.h.......................................hss.pLcG..............................................................hplTQtAhppthG.uaGupFluluLlLFAFSollu.YYYuEsNlhaLh.sph+ulh..haRlshlAhVhaGoltshsllWphADlshulMAlhNLIAIlLLpplsachhKDYhcQhKpGhpP.Fcspch	................................................h...............t..t..p..p..p..p.u...slSsF.Q.ALssuLAupVGoGNIAGVAsAI.......s........hGGPGAlFWMWlsAhlGhAotasEuoLA.hY......+.............p...+..-..t...s......G..p.ap......GGPhYYl........p.........+....G.L.......s.........t...........+..............W........h.......u.......l....l.......F.....A.....lh....l.l......l........u........h........G......h....h........h.....s....sl.....Q.......u........N.......o.......l..................u..................p..............u...............h................p...............s................u..............a..............s..................h.............s..............s...............h..............l..............s.................G.............l........l..L.s.......l...ls..u...l.l.Ih.G.G.l.+..p..Iu.plsphlV..PhMAlhYllsulhllhhNhsplP....sshthIhpu.A.F...s..h..p....u......u.s.G.G.h.hG...s...s...l..........................h.GlpRGlF..SNEAGhGSAP.AAA..uA.psp..............H....P..scQGllphhGlFlDTlllCThTAhlIL..l....o...G....h...................................................................................................................t....s...s..h...p...G......................................................................................................................s...t....l.Tpt.Ah...s..shh......u.......s......h.......G..s.....hh.......l.s....lu....lh....hFA..Foollu.hYYuEp.s...........lt.a......L.......h....................s.........p...p.....h.....l..h..............laR.......l...l...h....l............s.....h.l..hhG...u.......h.........h...........s.......l...s....h.........l...WslADlh......hGlMAlsN...LIAlll...L...u....thshphh+DY......p.p..h..c....t.................t................................................	0	285	542	723
+3460	PF03390	2HCT	Na_citrate; 	2-hydroxycarboxylate transporter family	Mifsud W	anon	Pfam-B_3683 (release 6.6)	Family	The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate [1].	25.00	25.00	25.00	27.90	22.10	24.10	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.36	0.70	-6.10	36	838	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	694	0	149	549	5	398.60	39	93.58	CHANGED	+IsslPLPlallhuslllluhhh...........spLPssMlGuhulhhlhGhlhGpIGpRlPIl+s.lGGuAIlslFlsohlVaasllspsslcssoshM.Ks.......u.sFL.hYIAsLlsGSILGMsRclLl+uhl+hhssllsGslsAhhsGhlVGhlhGh..........shpcshhaIllPIMuGGhGtGAlPLS..hYuplhG.hsppphhSpllPAlhlGNlhAIlsAulLsplGc+pPcLoGNGp.Ll+spp.....htsp.pcpptplshpthGsGlllAsohFhlGtllschl.......sl.uhshMIlhsAllKhhsllPpphcpGAhphapFhusshTasLlsGlGluassLsplluAl.ohsalllshslVluhlhsuhhlG+lhshYPlEuAIsuG.CtushGGTGDVAlLSAusRMpLMPFAQISoRlGGAhhlllAslL	...........KIsulPLPlYlhh..hh.llhlsthh..............spLP.s.shlGuhAlhhhhGhlhGpIGp+lPIhpp.lGGsulhshhlsuhhVaasll................sp..s..lcusst.hM.cp.......................u..NFL.haIAsLlsGSILuMNR+lLlpuhh+hlssllsGhlsAhhsGhlVGhlhGh..................shpcshhalllPIMuGGhGtGhlPLS..hYuslhG...tsppphhuplIPhhhlGNlhAIlhAulLsplGc+hPp....LoG.pGp...Ll+pss.........sp..pcppptplshpthusGhllAsohFlhGhllp+hl...........sl..s.s.h.Ml.llsshlKhhslhPschcpGAppl.cFhSpslTasLMsGlGlshhsLp-llssl.ohs..lllshslVluhlssuhhl.G+hhshYPlEuAIsuu.CpushGGTGDV.AlLSAuNRMsLhsFAQIuoRLGGAIsllluoll....................	0	28	64	100
+3461	PF03553	Na_H_antiporter		Na+/H+ antiporter family	Bateman A	anon	Pfam-B_620 (release 7.0)	Family	This family includes integral membrane proteins, some of which are NA+/H+ antiporters [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.93	0.70	-5.39	38	7404	2012-10-02 15:12:49	2003-04-07 12:59:11	9	9	2159	0	1156	6794	758	256.90	17	76.09	CHANGED	sssFGs.ttShlu.ssshusthhtstlhsphp...........h.hhhpshshtlhuhhhhhhluhlhh......hhhslsshhpp..tsh.....................phshhthtt.............Phhslhhhslhth.hhsshsh.shhs.shshthh...hpssshhtshhhuuhsuhhhthhsth.......htphsshlscG.hpsMhhslhlllhAhuhuullpcsG.hssllpslspth.ps.........hthhshlhhlluhhlshusGsuauolsIhsslhtshstphshsh..........hshsusltsuushu-shsPhSsoslhsssshts...plsplp.sshshhhhhs.h.hhlhhlhhGh	......................................................................................................................................................................................hhhs....s.h....h..h.h.....h.........h.h.ttht................hh.h..........h.h.shh..hh.h.h..h............................th..........h.t......................................................................................ht...h.....................................s..hh.h.h..h..h..h.......h.h......t.h.....h.hh......s........h.........h...........h.................h..........h.........s........h........h.h.thh.................hp................s....................................................h........h...............s.......h.........h.h..u....hh....h...h..hh.h.th.............................h.tp..h.......p...h...h.....s.....c.....G....h.....p..s..M.....h.........h....h.hl.h.....lh.uh.u..h..u.ul..h.p.....p......h......G.....h.ls...s...ll.....p.....t.....l....h....ph.h...ps....................................t.t.h....h.h..h..s.h.h.l.l.u.hh..l..s.h..u..h.G.s.u...as....o.ls.l.h....u.s.l.h.h.sls.p.p.h..s.ls...........................hhh.s.u.slt...su...us.hs.s.th..Phu..s...s.s......l.....h......s........sh....h..........................t..........h.......s...........h............h........h..s..h..h.....h.h..............l..hhh...............................................................	0	401	740	997
+3462	PF00287	Na_K-ATPase		Sodium / potassium ATPase beta chain	Finn RD	anon	Prosite	Family	\N	23.30	23.30	23.30	23.70	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.96	0.70	-5.63	11	608	2009-09-11 13:38:36	2003-04-07 12:59:11	13	6	122	10	324	552	0	246.50	31	90.97	CHANGED	MA+.cpccs........p.supWKcFlWNPcppEFhGRTuoSWshILLFYllFYGhLAGlFshTlhVMLpTls-apPKYQDR....lAsPGLhhpPcs..sp...hEIsFssu.sspSappaVpsLppFLcsYssopQsp....hpsCs..PscYh-pss.s...pspKKuCpFptphLG.sCSGlsD..sFGYs-GKPCVllKhN......RIlGFpPcs...............s.......ssh.lpCsuKcsE..tpplsslpYaP.s.....GshsLhYaPYYGKphpssYlQPLVAVpFsNlo..tssEltlECKla.usNlphs-.+D+F.GRlsFK	.......................................................................tth.ppah.a...ssp..pt...ph.hGRTstuW.........hh..Ihl....FYlhFYs.hLsuhFshsh.h.s.h....h...T.l.s..s.h...h..P....p...a...p..-p...................hs...s..P.G......l....hhtP.s............tt.......h...l..a..phs..c..spoaptaspplppFL....p.......Ypss.ptp..........sCs.........tthh.p.t............tpsCpFph.p........L.....t....sC....Suhp..D.....aGYpp...G.p.PClhlKhN......................Rl.lsahPp..........................................................t..............ssh...ls.Cp.s....p......p........t....t......c.........t..p.......p.......l.......sp.l.......pYaP.s....................sh..s......h.h..Y..a...P...Yh...s...............p....s..sY.....h.p...P....LVAVp..Fh..shs............hshtlplcC+hh.upNl..s.p.tcc.h.Gphth.............................	0	79	107	205
+3463	PF00939	Na_sulph_symp		Sodium:sulfate symporter transmembrane region	Finn RD, Bateman A	anon	Pfam-B_1100 (release 3.0)	Family	There are also some members in this family that do not match the Prosite motif, and belong to the subfamily  SODIT1.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.60	0.70	-5.62	11	6208	2012-10-02 15:12:49	2003-04-07 12:59:11	14	27	2554	0	1377	7719	2167	426.10	24	91.05	CHANGED	tsphhpLlhhlslhllIahlPsPsGlsspAWphFAIFhusIlGlIhcPlPhuslAlhululh.llstsLs..................lstuLSGFussssWLlFsAFhlutGah+TGLG+RIAhhhlphhGpoo..LsLGYullhs-llLAPuhPSsTARuGGIlaPllpuLss..........uhGSsspcs.................................o.+plGuaLMhssh.uosITSuMFLTAMAsNsLshslhsp...hsGhploWhpWhlA....AlssGllhLllsPLllYhlaPPclcps.............-shphAcpcLcpMGPhstpE+tllslhlLsLlLWlFGs...........pls......lsAoTsAllslulhllhp.....................llsWc.DllpppsAWsTllWaGuLIsh..AshLspsGFlpWlusshsshlu..uhssthuhhlllhla.ahsHYhFASsoAaluAMhPlFluVupul.G.ss.hhhuLsLsFusulhGhlT.YGoGPuPlhaGuGYlsspcaW+hGhlluIlslllaLslGshWWphLuhh	..........................................................................h............h.h..h...h.h..h.h...h...h..s...h.....s...................s.........h.....s..................s....h..h.........h.........hu..............l..hl..............hh...hl..h...h...l.h.c...s...l.Ph.s..s.s.u..l...l.s...h..s.lh.....lhs.hh.......................................................................................p...s.h.u.u.a.us.s..slaL.hhuu..Fhluhu..hpc.ps....L....s...+R.l.A..h..h.l..l..p...h..h....G.p...p.s.................l.h..l..u...a...h..h..s..h..s.....l...h..h.....s..s..su...s..oA..h.h..h..s..l..h..h...s.l.l...p.s.ls.........................................h.t..s.p...p.p............................................................................................................................................................................................................................t.p...h.u.th...l.h..h.s.h.hhu.s...s...lsu.hhh.hsu....s.s...s.Nh.l.hh.t..hhpt....................t..h..p....l..s..ah..p..W..hhh.....uh.P....s..l...l....h....l.....h.l...h....h.......l.h....h.h....h.a.........s...p....h....p..p...h....................................................................t..s....t...h..h.....p..p...c.h...p.p...h...G.............h..s..h.....t...E......h......h...h....l.......s.......l...h..l....l..s..l..h......h..........W......h......h..t.s..........................................ht..................l...s...s..s...s..l..u...l...h..s....h.s..l..h....h..h.hs.....................................................................l..l...s....W...c........h.....h.....p.....p..p.....h.s......W.....s.....s.l.....lh.....h.uuh..lsl..............uss..L..p.p..oG.h..hp.al............uptl..ts.h..hs...............h..t..............s.........h...s.h.h.h....l..............l..h...l...h...h.h.h..h..h......F.s..S.s..o.A...ts....s....h.h.h....P.l...h....hs..l..........u..........h...u...h.......................u.......h..........s......s......h......h....h...s...l.....h....h...........s....h....u....s..u....h...s......hh....h...Phus.......s..P.....s..s.....l.......h..........a........G........s........G......h........l.....p..............h.....p.......c......h..h...+....h......G.....h....h....h......s....l...l.s...h........l...l...h.h...h.h...s.............hh......h...........................................................................	0	425	767	1127
+3464	PF04902	Nab1		Conserved region in Nab1	Kerrison ND	anon	Pfam-B_6188 (release 7.6)	Family	Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors [1]. This C-terminal region is found only in the Nab1 subfamily.	25.00	25.00	26.50	44.50	17.60	18.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.04	0.71	-4.76	2	61	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	38	0	27	45	0	154.70	68	34.82	CHANGED	GERDELSPKRIKVEDGFPDFQ-sVQTLFQQARAKSEELAALSSQQsEKsMAKQMEhLCsQAuYERLQp.ERRLoAGLYRQSStEHSPsGLsSDsSDGQGERPLNLRMPNlQNRQPHHFVsDGELSRLYsSEAKSHSSEsLGILKDYPHSAFTLEKKVIKTEPEDSR	..GERDELSPKRIKlEDGFPDFQ-oVQTLa.......QQ..........A..+AKSEEhsALuSQ.........Q.sEKV.MA..KQMEFLCsQAGYERLQpsERRL.SAGL.YRQu..SEEHSPN.GLsS.D.sS.DGQ.GERPLNLRMP..N..LQ.NR.....Q.P..HHF.....VlD..........G..........E..........LSR.L.Y.s...S...E.AKS+SS..E.SLGILKDYPH........S.AFT.L.EKKVIKTEPEDSR..........	0	1	4	10
+3465	PF01849	NAC		NAC domain	Bateman A	anon	[1]	Family	\N	21.30	21.30	21.40	21.40	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.73	0.72	-4.44	91	1327	2009-01-15 18:05:59	2003-04-07 12:59:11	13	15	510	10	771	1213	39	57.30	36	25.22	CHANGED	pKKhpphhc+lGl..cplsslpcVslpp.sctphlhhspPcVp..pu.s.ssoahl..hGcscpcs	...............-KKhpp.sl.pKLGl.....psls.Glpc..VshhK.sc..shlhhhsp.P.cV..............tS.s..usTahl.hGcuchc...................	0	231	389	577
+3466	PF00175	NAD_binding_1	oxidored_fad; NAD_binding; 	Oxidoreductase NAD-binding domain 	Sonnhammer ELL	anon	Prosite 	Domain	Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.61	0.72	-3.49	72	19747	2012-10-02 19:13:12	2003-04-07 12:59:11	16	239	4712	191	6047	15837	2129	105.10	20	24.44	CHANGED	hlu.GGoGluPhhshlpphhtt..p...........tspshl.haGs+spc.cll..hc-Elcphttph.t....hhh.h..........ppssss.tst+GaVpctl.c..ch.............ttth.lahCG.P.sMhcsspp	..............................hlu.uGsGlsPhhu.hl...pp...h..h..t.....p....................................................ptsp...h.h...l...h..aus...R..........stp....-.......h..h.........a....t.c....-.l.p...p......h..t.pph................h...h.hhh.............................spsp..s.....s..............................p.....G...h...l.s....p.....t..l....h...p..phht.................................t.s..s.p.l.a.l.CG.sssMhcsst.t......................................................................................	0	1691	3423	4899
+3467	PF03446	NAD_binding_2		NAD binding domain of 6-phosphogluconate dehydrogenase	Griffiths-Jones SR	anon	Prosite	Domain	The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.76	0.71	-4.40	163	12732	2012-10-10 17:06:42	2003-04-07 12:59:11	10	80	4225	91	3550	30059	15093	161.10	28	46.30	CHANGED	htpIGhIGLGlMGpshAhNl...h.ctGasVslas.Ro..t.....spscphhtp...u..........hhsstohp.-hspsh......chllhhVtsussVcsll.s........lh..stl........ptG..sllIDsussphpsspchscp.lpppG..ltalsusVSGGptGAtpGs.olMsG..Gspp.uacplpP.llpshus.........sls.......h.Gs	..........................................................................plGhl...G.L.G.h.M.......G....t...s....h....A..t..Nl.................h...c....t....G........a......s.......V......s....l.....a..s.....p.s......t...........p...t...s...c.....p...h...h..t.p....u.......................................st..s.s..t....o...s.p....-...h..s..p.sh.........................chl...l...h.........M......l..........s.........s..........u..........s...........s..........l.......c.........s..........l........l.......s.......................l..h.....s.t..h..................................................p..t...G.......s....l..l......l...D.......t...u.......s.....s.s........p..s.......s.p.c.h.s....p.......t.......l....p.........t......p..G.............h.p...............a.....l...-.........u....s...........V....S..G........G..p...t..........G...........A...t.p......G.........s.............olM..s...G..........G...s....c...p......s....a..c..p..l...p.P...lh.p.s.h.us...........slh.h.G.t...........................................................................................................................................	0	986	2066	2904
+3468	PF03447	NAD_binding_3		Homoserine dehydrogenase, NAD binding domain	Griffiths-Jones SR	anon	Pfam-B_459 (release 2.1)	Domain	This domain adopts a Rossmann NAD binding fold.  The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.33	0.71	-10.36	0.71	-3.70	30	6031	2012-10-10 17:06:42	2003-04-07 12:59:11	11	30	4281	27	1498	6276	2360	124.60	26	23.63	CHANGED	GhGslGsslhchLpcstt........slclsulsscc...hptt..........htshhsstshsssl-clls........c.sDllVEs.uu.pslcphshphLcpGhcllssshuAlu...shhtcLhphAcpsssclhh.	.........................................................................GhGsV..Gu.u..l.l..c...l..l...pcppptltt...............phshplp.lss..l.ss..pc......h.ptp........................................ht.t.t.h..s..s..t..t...h....s....p..s...h..p.....p.llp...............................p.hsl.lVE......l...u......u......s......p.....s.....s.....t.....s.....h..h..h.c..sL.p...p..GhHV.....V..T.A.NKs..hhA.........sahppLtph.A.cpss.hphhap.................................	0	464	940	1256
+3469	PF01210	NAD_Gly3P_dh_N	NAD_Gly3P_dh; 	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	Finn RD, Bateman A, Moxon SJ	anon	Prosite	Family	NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain [2].	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.72	0.71	-4.50	44	5998	2012-10-10 17:06:42	2003-04-07 12:59:11	18	26	4763	27	1531	8856	4915	150.50	28	44.49	CHANGED	pluVlGuGuWGTALAtlLucsu........ppVplWspcs.........phhcplspp+p.NscYLPs.lhlPs.slpsssDLtcAlpsu-hlllsVPopshcplhpplpshl.....ppsshllt........ssKGl...Et.........sohphlScllpEhlstp....luVLSGPshAcEVAtth.osssluu...pstphu	....................................................................lsVl.G.u.Gu.a......GT.A.l.A.h..hl..ucsG............ppVh.lW.s..p..p............................................chh.p.p..l......p......p.......p.......+......p.......N..................p..........a.......L..........s.....s.......h............t.......h.......s........p.......s..........l...........p.....s.....s......s........D....l....t.........p...A.....l.............p......s......u...............-......h.....l......l.h.s..l..........P..o...........p...........s........h..c...p.........s..h..p.p....l..t..s..hl..............pss...s...h...l..l.t...........................ss..K..Gl................E.............................soh.ph...h...s..c.l...l...p..-.......l.stp.................luV.lSG.....P..saA.pE.lutt...oshsluu.ps.p..h.......................................................................................................	0	513	967	1299
+3470	PF01513	NAD_kinase	DUF15; 	ATP-NAD kinase	Bateman A, Wood V	anon	Pfam-B_797 (release 4.0)	Family	Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.62	0.70	-5.63	33	6066	2012-10-02 15:20:27	2003-04-07 12:59:11	16	26	4752	59	1890	6136	3391	258.10	24	81.92	CHANGED	plullssss....................ptpstthspcltchLhsp........shhhh.ttthtt..........................................................phhhhshphhcpss-hllslGGDGThlsssphhsp....slPllGlss.GshsFhsph..p.cshtphlsphlp.schplpct.....hl-...........................shlppspp...............hh..thslN-hslhtutssphhp..hclhlssshhsshts-Gl.............................lluTPsGSTuashuuGGsllpPsltsh.l....s.....hhhttcslVlssppplph.......ppsshlshDGppplpht.sshlplphu.pt.hhhlch	........................................................................................................................................h.......................................................................................................................................................................................................................s..p...p..s...D.lllslGGDGThLpAs.+t..h..tp...............s..lP..l....l.G.l....s........t......G.....p...L...G..F.....L....s.-.h...............psp..p.h....p..ph.l....p.....p.l..........h..........p...s..............p......h......p...l......p....p..+.......hLc.............................................................................................................................................................sp.l...p.ppsp.....................................................................hh.ph..h.A.l..N...E.l....sl....pp..u.s..t.sp.hhp...........h-l....hl...c.s.....p....h..h....p...s....h..puDGl....................................llSTPTG...STAY..shS...u.G..G...sl.....l.p.P.s.lp.u.l.hlsPlss.........+s.ht.sR...Pl...V.....ls.s.p.splplph...............tppshh....ls...hD.u..p...t..h..t..h..p.s...ppl..lphst...hphh...................................................................................................................................................................................................................	0	612	1178	1585
+3471	PF02540	NAD_synthase		NAD synthase	Mian N, Bateman A	anon	COGs	Domain	NAD synthase (EC:6.3.5.1) is involved in the de novo synthesis of NAD and is induced by stress factors such as heat shock and glucose limitation.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.63	0.70	-5.47	11	9645	2012-10-02 18:00:56	2003-04-07 12:59:11	12	26	4887	87	2593	10500	6866	175.90	22	39.30	CHANGED	llpclpsFl+phVpcsGs.pGVVlGLSGGlDSulVAhLshcAl.........Gp-psluLlMP.s..ssccDhpcAhslscpLuhphpplsIcshhpuasp....thppst....pchscGNlKARlRMshLYsaAsphshLVlGTuN+oEhhlGYFTKaGDGusDlsPIusLhKopVacLA+tls.....lPccllcKsPoAsL...asGQTDEcELGlsYc.LDplLp....hhp.t...p-..tthslstphscpltphlpKoEHKRc.P	........................................................................p.......hlt.p..h.h....p....p.....s....Gt.....c....p....l..l.......L.G..l..SGGlD...S..o....l...s....u....t....L....s...p....c.A..l.............................................u..p...p...p.....l.h....s..l.....h...l............s...........s..............h..................t..........p..........p............p..............p..............h..p..t......s......h......t.......h..h....p.t...h.....t.....h......p.....h.....h.....h......l.....s....h.....p........h..h...........t...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	860	1651	2190
+3472	PF00146	NADHdh		NADH dehydrogenase	Sonnhammer ELL	anon	Prosite	Family	\N	20.00	15.00	20.00	15.00	19.90	14.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-11.82	0.70	-5.37	23	21511	2009-01-15 18:05:59	2003-04-07 12:59:11	16	18	13672	0	1222	18971	2989	236.20	39	95.74	CHANGED	hhllshLhlIlsllluVAFLoLhERKlLuhhQhRKGPNhVGshGLLQPlADGlKLhhKEslhPusushhlFhluPslulhLullhWsslPhshshl..shNlGlLFhLAlSSLuVYulLhuGWuSNSKYuhLGuLRAsAQoISYEVoLuLILLol.llhsGSashsslspsQp.....hhWhlh.phPlhlhaaISsLAETNRsPFDLsEuE.SELVuGaNVEYuussFALFFLuEYuNllhMshLs.slLFLGu.h.............................s.hhhhhKshhlhhlFlWlRuohPRaRYDQLMpLsWKsaLPLoLuhllhhsulhl	...............................................................................h...lh.h..h.l....l....L...l.u....l....A....a...h....o..l......h...E.......RK.lLuah.QhR+GP........N...........h..........V...........G.......................h..........G......l......L......QPhuDulKLh.hK.E......l.h.Ptt....u.s........h....l..a.h.hs.Phl.u...l..h..l........u..lh.h..a.h..........l.......P.........h....................s..............h................s............h..............h........................................................s...........h......s....l...u..l.L..........a..........h..l........s..h.o.Sl..u..VY.sl......l..h........uG.Wu.S..N...SKYuh....lGul..Ru..sA.Q..sISY.E..ls.h.s.l.h.l.l...s........h......l.h..h......s........u.............s..........h...s...h.......p..h..........s.Qt..................................h.W......h......h......h...................h...s....h...h...h..h..a.....h....h..ss...l....A.......Es....N.R...tP.FDh...s...E...u..........E...pE....L..s...s.G..a......h...EY...u.uh.Fuh.h....h.h.u....E.Y.h.....t.h.h....hh.shh.....s.h.ha..h..s.s..........................................................................................h.hhhc.h.....h...h.....h.h...h.h...h.c.shsRh...Rhs...h.....hh..W.h....h......................h..................................................................	1	394	766	1015
+3473	PF02477	Nairo_nucleo	Nairo_nucleocap; 	Nucleocapsid N protein	Mian N, Bateman A	anon	Pfam-B_2892 (release 5.4)	Family	The nucleoprotein of the ssRNA negative-strand Nairovirus is an internal part of the virus particle. 	25.00	25.00	41.20	28.40	17.60	17.10	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.50	0.70	-5.79	3	472	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	16	1	3	283	0	180.00	74	96.38	CHANGED	MENKIcANNK-EFNcWFKpFuEKppLsssaTNSASFC-cVPsL-pacaKMALATDDsEKDSIYSSALVEATRFCAPIYECAWsSSTGlVKKGLEWFDKN..uDTIKlWDAsYh-LKsElPcsEQLluYQQAALKWRKDVGFcINpaTuuLoHsVlAEYKVPGEllhslKEMLSDMIRRRNlILNGGGD-APKRGPVSREHV-WCREFAuGKFlsAFNPPWGDINKuGKSGIPLlATGLAKLAELEGKcVhD-AKpoltsLcGWV--NKDpVDcuKA--LlpslpKHlAKAlELuKpSNALRAQGAQIDTsFSSYYWsWKAGVTPETFPTVSQFLFELGKsPRGsKKMpKALlSTPLKWGK+LIELFADDDFppNRIYMHPAVLTuGRMSEMGlCFGsIPVASPDDAAQGSGHTKuILNaKTcTEVsNPCAsTIVpLFEIQKsGa	..............................................................h.hpMA.ATDDupKDSIYASALVEATKFCAPIYECAWsSSTGIVKKGLEWFEKN....uGTIK...SWDEsYsELKV-VPKIEQLANYQQAALKWRKDIGFRV.NANTAALSNKVLAEYKVPGEIVMSVKEMLSDMIRRRN.lLN+sG.--ss...............................................................................................................................................................................................................................................................................	0	3	3	3
+3474	PF04131	NanE	nanE; 	Putative N-acetylmannosamine-6-phosphate epimerase	Mifsud W	anon	COG3010	Family	This family represents a putative ManNAc-6-P-to-GlcNAc-6P epimerase in the N-acetylmannosamine (ManNAc) utilisation pathway found mainly in pathogenic bacteria.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.22	0.71	-5.33	7	2374	2012-10-03 05:58:16	2003-04-07 12:59:11	9	5	1884	8	180	1739	546	188.00	47	81.67	CHANGED	hstMAhAut.uGAsGlRhpGVpslpthpshVslPIIGIlKRDhPssslhITshhp-lDpLAssGs-lIAhDuTsRsRP..lsl-shlcpIKcph..pLhMADCSohEEGlhspphGh-hlGoTLSGYTssp.s...s-PDapLl+sLspAGhh..VhAEGRhsTPE.Apcsh-hGssuVsVGuAlTR.ccIsphFspAlpp	...................................................................................................hutMAhAAppuGAVuI.......Rh........p...ul...p...s.lps.l.+p.h.V..s.lPIIGIlK......R.D.h.s...s....s..s.V..a.....IT.s.s...h.c....-VDtLsp.sGs.-lIAlDu..Tt.RpRP.......hslp.phlp...pI...+.c.+h..........hL.h..M......A.D.s.S.o....h...E..-....u..l....s....A...tc...h...G.hDh....l.........G...T..T..L......S..G.....Y.....T..s..sss.........ppP..D.....h.....p....L.....l....+...p....L....s....c....s......s..s......VIAEG.+hpTPppAtc.s.h.c.h.GAauV..VV..G.u..A..I.T...R...Pc...c..IsphFssAlc.......................................................	0	49	100	147
+3475	PF04660	Nanovirus_coat		Nanovirus coat protein	Waterfield DI, Finn RD	anon	Pfam-B_4486 (release 7.5)	Family	Family of conserved Nanoviral coat proteins [1].	25.00	25.00	143.60	143.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.99	0.71	-4.56	3	85	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	11	0	0	65	0	166.00	74	99.27	CHANGED	suRWshpGhK+RRosRRKYGRhAYKP..PoS+VVSHluSlLsK--VVGs.EIKP.DuDluRYpMhKVMLlsTL+MsPGELVNYlIVKSSSPIANWSouFosPuLhVKESsQDhVoIVuuGKLESuGsAG.oDVTKSFRKFl+LGuGISQTQHLYLlhYoSsAlKIsLEsRlYI-V	....huRas+puIKKRRVGRRKYGS.KA.....ATSHDYSSLGSILVPENTVKVFRIEPTDKTLPRYFIWKMFMLLVCKVKPGRILHWAMIKSSWEINQPTTCLEAPGLFIKPEHSHLVKLVCSGELEAGVATGTSDVECLLRKTTVLRKNVTEVDYLYLAFYCSSGVSINYQNRIhhcV.	0	0	0	0
+3476	PF00956	NAP	NAP_family; 	Nucleosome assembly protein (NAP)	Finn RD, Bateman A	anon	Pfam-B_1009 (release 3.0)	Family	NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity.  They affect the transcription of many genes.	26.90	26.90	27.30	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.60	0.70	-5.25	97	1619	2009-01-15 18:05:59	2003-04-07 12:59:11	13	20	399	31	836	1514	9	214.90	28	67.14	CHANGED	+..p+l.psLcplQtchppl-tcapcchhcL.Ep+YtphhpPlap+...RpcIlsG.h...tsp....................................................................................s.lP.sFWLssh.cNpshlu..phIs.-cDcphL.caLpDlchphhcs...............uFpl.FpFss...NsaFpNp..lLoKpYhhps.....p........................pspuspIcW+.pu+slThphhp+....................KpcpKtpt..th+.lpct..tc...........SFFNFFs......s.......p...........................t.t..ptpchp..t.ht.DaclGphl+-cllPcAlpaasGcs	................................................................................................................................tlttLctlQ..chsplptph.cchhp..........l.EpKatph.hp.Ph...ap+...Rp.pllps...........................................................................................................................................................................................................................................................................................................................................IP.sF.W.hss.......h..tN..ps.........lu...............thlp...-pDEth.L..caLpc.lclp..hct..........................uap.l.pFhFpt......N.sY.Fp.Np.............lL...s..K.pah..hpp.....psp............................................................tspuspIcW+..pGcs.lsh.ph.pp......................................................tp.ppptt................p..............................................SF.Fs.aFs........................................................................................................t..t..p.t.................s.cluphl+-clhPpsl.aah...............................................................................................	0	233	366	559
+3477	PF03892	NapB		Nitrate reductase cytochrome c-type subunit (NapB)	Bateman A	anon	COG3043	Family	The napB gene encodes a dihaem cytochrome c, the small subunit of a heterodimeric periplasmic nitrate reductase [1].	21.10	21.10	21.20	21.20	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.10	0.71	-4.48	75	1044	2012-10-01 23:37:15	2003-04-07 12:59:11	9	3	988	11	158	429	23	131.50	46	86.09	CHANGED	hhshsssussssssp.......................ltsLRsss.lssp.ssssshpph.....spcstphpRsYspQPPlIPHsl-u...YplshssN+CLoCHuhppspcstAshlSsTHahD..R-GphL.uslSPRRYFCsQCHVPQsDu.pPLVpNsFpsh	..............................hhs.hsshstssts.................................................t.s....sst.-..shh+h.......P+Epp+hshsYVNQPPhIPHSl-G...YQ.VTpNsN+CL.pCHuh.....-....s....h+s...o.GAs+ISsTHF.h.D....p..................DGK..Vs...upVuPRRYFCLQCHVPQuDs.tPlVsNoFpP.s....................	0	28	80	125
+3478	PF03927	NapD		NapD protein	Bateman A	anon	COG3062	Family	Uncharacterized protein involved in formation of periplasmic nitrate reductase.	28.00	28.00	28.20	28.20	26.40	27.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.32	0.72	-4.15	59	1029	2012-10-02 00:20:33	2003-04-07 12:59:11	8	1	992	2	164	424	22	78.70	39	82.85	CHANGED	pch.HIsSLlVpspPcclspVpssltslsssEIauhssp.GKlVVllEusspttlhcplspIpslsGVLssuLVYHp...h-st	......p.phplsSLVVpA.Ks.-.+.l.sslpspLsshPus.Eltss....-s..Gp.....LIV.VlEu-sp....-sllpoIEu.lcslcGVLuluLVYHQQ-p.............	0	34	85	130
+3479	PF03059	NAS		Nicotianamine synthase protein	Mifsud W	anon	Pfam-B_2173 (release 6.4)	Family	Nicotianamine synthase EC:2.5.1.43 catalyses the trimerisation of S-adenosylmethionine to yield one molecule of nicotianamine. Nicotianamine has an important role in plant iron uptake mechanisms.  Plants adopt two strategies (termed I and II) of iron acquisition.  Strategy I is adopted by all higher plants except graminaceous plants, which adopt strategy II [1,2]. In strategy I plants, the role of nicotianamine is not fully determined: possible roles include the formation of more stable complexes with ferrous than with ferric ion, which might serve as a sensor of the physiological status of iron within a plant, or which might be involved in the transport of iron [1]. In strategy II (graminaceous) plants, nicotianamine is the key intermediate (and nicotianamine synthase the key enzyme) in the synthesis of the mugineic family (the only known family in plants) of phytosiderophores. Phytosiderophores are iron chelators whose secretion by the roots is greatly increased in instances of iron deficiency [2]. The 3D structures of five example NAS from Methanothermobacter thermautotrophicus reveal the monomer to consist of a five-helical bundle N-terminal domain on top of a classic Rossmann fold C-terminal domain. The N-terminal domain is unique to the NAS family, whereas the C-terminal domain is homologous to the class I family of SAM-dependent methyltransferases. An active site is created at the interface of the two domains, at the rim of a large cavity that corresponds to the nucleotide binding site such as is found in other proteins adopting a Rossmann fold [3].	23.80	23.80	23.90	23.80	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.86	0.70	-5.24	13	220	2012-10-10 17:06:42	2003-04-07 12:59:11	11	2	133	12	98	214	3	240.50	29	85.46	CHANGED	spN...ssslVcKIssLYstIS+LsSLs....PSscVssLFTcLVssClPssP.lDVoK..Ls..clQchRspLI+LCupAEGhLEuHaSshLuua-.NPLsHLshFPYasNYl+Lo+LEaslLupasst.sPs.+lAFIGSGPLPLTSlVLA.....opHLs.....................sTsFcNaDhsusANspAppLls.uDssL.usRMsFHTuDlsclss-LssYDVVFLAALVGMspE-KsKllsHLu++MAsGAsLllR.SAHGA.....RuFLYPllDPp.Dlp..GF-VLulaHPs.D-VlNSVIlARKhh.ss	...............................................................................................tt........hltplhth.ttlt..pL.s.t......p...p......pth...Ft...pL...hs.....p....ch.p.....Lt...phpthhtplhplps.ApuhLEtahu.p....l...s...uh..p......s........P....p..p.......l.p...F...sYassY.pLsphEhphhsh..thst..........st..+VhFlGSGPLPhoullLs.....tph.hs....................................sshh.shDh-ssA....tphAp.pLlp...s...s......L........p.pphp.Fhsss...h.t.p............h..s..p..s.lt.taDhlhlA.uLVu.......pKtplltpLtphhs.......s.....uu..hLlhR...supGh.....Ru.hL.Y..s...lc.t...pht...saphhs.h.P...........h.so.hh........s......................................	0	27	56	80
+3480	PF04159	NB		NB glycoprotein	Bateman A	anon	Pfam-B_1501 (release 7.3)	Family	The NB glycoprotein is found in Influenza type B virus.  Its function is unknown.	24.40	24.40	24.70	80.70	21.60	24.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.43	0.72	-4.27	24	1614	2009-09-10 20:28:57	2003-04-07 12:59:11	8	2	1536	0	0	543	0	95.00	93	99.71	CHANGED	MNNATFNYTNVNPISHIRGSVIITICVSFTVILTVFGYIAKIFTNKNNCTNNsIGL+ERIKCSGCEPFCNKRDDISSPRTGVDIPSFILPGLNLSESTPN	....ATFNYTNVNPISHIRGSlIITICVSFIVILTIFGYIAKIhTNRNNCTNNAIGLCKRIKCSGCEPFCNKRGDTS.SPRTGVDIPuFILPGLNLSESTPN.............	0	0	0	0
+3481	PF00931	NB-ARC		NB-ARC domain	Bateman A	anon	[1]	Domain	\N	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.75	0.70	-5.55	12	16257	2012-10-05 12:31:08	2003-04-07 12:59:11	17	1033	906	35	4750	16655	176	210.80	21	35.74	CHANGED	hcs.l-plhp+Lhp.p...pphtllulhGMGGlGKTTLAppla.pc.p.lpppF.DhhhWlsVScphst....hclhcs..lhpcLt.ss..h..........................spcs.sp.httclpchLppK..RaLllLDDVWcc...pa-plt.shsstp.ts+lllTTRspsVstthss..sphhplp.hLp.-cuWpLFppc.....shcpp..........tpsplE-lu+plspcCpGLPLulpslGuhhtpKp.pl.pEWcchhcp.hppphht..p......splhs.hlthSYcsLst.pLKpCFlhhu.......hFPcshphttcplhchWhspshl.sps.	.....................................................................................................................................................................................................u..G..l..GK.TT.......l....A...........p.....t....l........h....p.......p.........................h.......p.........p.....p.........F........p.....h.....h.....h......a.....l............s.....s.....s....p....p..h.sh.................hpl...pp.......l...h...p...p..l.....t..h.p.......................................................................................t...s.....pp.....hh....ph....l....p......p.....h.....L.......p.......p....+...........+.............h...L......l....l....L....D............D.........l...............p.p...................ph.........p...........t...............l...........t......t..................h.....................................h........s..............................G...........o............+.........l...l..l...T......T..................R.........p.........p.........p.........l..............h......t...........h.........h........t......................................t........t..............h.......h.....p....l........p............L................s............p....p...........c.....u....h....p....L.....Fp..pp.......................................s.h..tpp.................................p.h............p.....l...u.......p.......p...l...s..p..h.......s...t...G.......l..P.L.Al...................h....s..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	726	2813	3845
+3482	PF04485	NblA	nblA; 	Phycobilisome degradation protein nblA 	Kerrison ND	anon	DOMO:DM04316;	Family	In the cyanobacterium Synechococcus PCC 7942 (Swiss:P35087) , nblA triggers degradation of light-harvesting phycobiliproteins in response to  deprivation nutrients including nitrogen, phosphorus and sulphur.  The  mechanism of nblA function is not known, but it has been hypothesised that nblA may act by disrupting phycobilisome structure, activating a protease or tagging phycobiliproteins for proteolysis. Members of this family have also been identified in the chloroplasts of some red algae.	25.00	25.00	27.10	27.00	23.20	20.70	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.41	0.72	-4.10	14	86	2009-09-10 15:48:25	2003-04-07 12:59:11	7	1	55	22	26	74	5	52.30	38	84.84	CHANGED	s.sLoLEQcFpLphappplpplshEQspchLl-hh+QhMl+-Nll+tllKpuh	....pLSLEQpFpLpshpppVpphSpEQAp-aLlchhcQhMl+-Nhh+pLlKpp.....	0	3	18	26
+3483	PF03801	Ndc80_HEC		HEC/Ndc80p family	Bateman A	anon	[1]	Family	Members of this family are components of the mitotic spindle.  It has been shown that Ndc80/HEC from yeast is part of a complex called the Ndc80p complex [1]. This complex is thought to bind to the microtubules of the spindle.	20.50	20.50	20.70	20.50	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.88	0.71	-4.80	37	358	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	283	5	242	368	4	153.10	29	25.72	CHANGED	stpc+oshht........sRsShs....shtspps............+DPRPL....+D+saQsphhpplhcaLsppsa....spslo.+sLpsPopK.-FhtlFpaLYpp.lDPsaca...tp.ph-pEl.plLKpLpYPa..sIoKSplsAlGusp.WPphLuhLpWLhpLsphhsphhsp.......Dpshtspth	............................................................................s..................R.S.h.......s...t.tp...................pDsRPl.........pD+saptphhpplhcaLspp.sa............ttsl.o.....p..sl.ps.....PotK.-F.hlFpaLapp...l-.Psaph.......................pp.ph.--E.ls..lLK.pLpYPa..sloKSpltAsGusptWPphLuhLpWLhclsp.hhpthhppp.............ss.t......................	0	82	134	203
+3484	PF00334	NDK		Nucleoside diphosphate kinase	Finn RD	anon	Prosite	Domain	\N	21.60	21.60	21.80	21.80	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.50	0.71	-4.37	171	5820	2009-09-13 01:46:53	2003-04-07 12:59:11	14	37	4319	479	1940	4004	2188	131.60	43	80.92	CHANGED	E..RThsllKPDuVpRs...LlGcIlsRh.Ecc.Gh+lluhKh.hplocchAcp..aY.....scHps.+P....FFssLlpahoS.....G.P....llshVlEG....c.sulptsRplh....GsT.sPtc.A...tPGTIR...u.DFuhsh........sc...NslHGSDSsE..oAp+EIshaFs...tpEl	.....................................................................E+ThslIKPD..u.V..p..+.s.............l.l.G.c.I.l.s.Rh.Epp..Ghcll.u.h..K..............h.h..............p.l..o.c-.p...Ac...p...aY................................u-.....H....ps...+P................F..Fs..s..L.l..c.F.MoS.................G..P.......l.l.s..h.............Vl...EG..............cs..Al.pp...hRplh.......G....uT..sPtc.A......................tsG.....TI..R...u..Dauhsh................sc........NslHG..S.DS..E..o..Ap+EIshaFst.............................................................................	0	667	1125	1540
+3485	PF05031	NEAT		Iron Transport-associated domain 	Yeats C	anon	[1]	Domain	This domain is involved in the transport of iron, possibly as a siderophore.	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.50	0.71	-4.11	53	2305	2009-01-15 18:05:59	2003-04-07 12:59:11	7	72	393	47	143	1431	4	121.10	25	39.58	CHANGED	ssspltcGpYslsaplhKcss....s-tShhssYhpcPuplplcsGKphlplTlss..o.....sahpshplp....sGp...........hhcscll...Scsp........tps.s+s.lcFc.Vsslspclssphplhl.....h...sYctpaplphthDsss	.....................s..pt.tssphslsapl.hKs...ps.....spp.S.hh..s.sah.p.cPuplhh.p.s..GK.hh.lp.h.slps...u......................sahpcaplp...tsst.............................thss.cll........ScDp...................pps...s+s..lpFt..Vs....s......hsppls.shlcl.l.....sp...h....sYcapYslph.hp...................................................	0	46	94	107
+3486	PF00880	Nebulin	Nebulin_repeat; 	Nebulin repeat	Bateman A	anon	Pfam-B_1603 (release 3.0)	Repeat	\N	20.10	20.10	20.20	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.86	0.73	-7.23	0.73	-4.11	143	8841	2009-01-15 18:05:59	2003-04-07 12:59:11	13	120	100	0	4092	7213	2	28.70	29	38.71	CHANGED	DsPphhpA+pssphhS-hpYKcsaccp+s	.....DsPchhpA+pstchhS....-..hpYKcsa-ct+........	0	255	486	1390
+3487	PF04299	FMN_bind_2	DUF449; Neg_reg; 	Putative FMN-binding domain	Kerrison ND, Bateman A	anon	COG2808	Family	In Bacillus subtilis, family member Swiss:P21341 (PAI 2/ORF-2) was found to be essential for growth [1]. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	20.70	20.70	20.70	21.20	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.14	0.71	-4.76	129	884	2012-10-02 11:35:36	2003-04-07 12:59:11	7	4	757	2	337	872	133	165.30	34	77.90	CHANGED	MYlPstFp..ts-hstltphlcppshuhLl..............o.t....ssss...l.AoHlPhlLc...tt..........sspshLh..uHlARuNPph...ppl................ptss.p..lLllFpGP.cuYlSPsWY.....ps.tcsVPTWNYtuVHsaGphplhp...Dsc......hltphlscLospaEssh.........tpPWp...hs-sssc..alcthl+uIVGhclpIscl	............................MYlPttFt...sc.ptltph.lpppshusLl.....................o.p...ssss.......Ao.HlP..hhLs.....t.........................tsspshLpuHlARsNPpappl................................ptsp..c....VLllFpG....s....cuY...ISPsWY...............ps.....tc.....t.....VP.TWNY.huVHsaGp.hplhp.Dpp............hltshlscLoppaEssh......................tsPWphs-ssts..alcthh+uIVGhcIplscl.............................	1	89	193	279
+3488	PF00960	Neocarzinostat		Neocarzinostatin family	Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	27.70	27.20	22.60	23.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.04	0.72	-10.55	0.72	-4.13	4	25	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	19	25	6	38	1	109.60	34	72.85	CHANGED	usoVoPAoGLSDGpoVoVSuoGhssGTsYpluQCAhVssGhhACNsAshoshTsDAsGpuosSlsVR+SFpGhlhs.GT.hGoVDCsTs..uCplGlGssuG-hup.sAIoFu	...........sloVoPuoGLoDGpoVoVouoGhssG.oshtluQC..As..ls..s..GthACssAsssssT.sDAsGss.osolsVR+SFsu.shs.Gsth.uoVDCs.Ts..uCtlusus...susssut.ssloF.....................................	0	4	6	6
+3489	PF03391	Nepo_coat		Nepovirus coat protein, central domain	Mifsud W	anon	Pfam-B_3589 (release 6.6)	Domain	The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure [1].	20.30	20.30	20.50	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.72	0.71	-4.99	11	339	2012-10-04 01:49:40	2003-04-07 12:59:11	10	7	28	141	0	391	1	168.10	69	25.28	CHANGED	PslsaPhps.tchphhhlhhPPhphsluussuhposshhhupshhsusppsYsasssLlSaaLGhGGol+GcV+psuosFhossLhVs.pWtGsosshppLhphPtshlct.DGphplcIpSPaacTss.hh-ututh.lss......luGPlAPpspsuphtahlpIcpIst..s	........................................PTLVFDPGV.FsGKFQFLTCPPIFFDLTAVTAL+SAGLTLG.Q..VPMVG.TTKVYNLNSTLVSCVLGMGGTIRG+VHICAPIFYSIVLW..VVSEW.N..GT.T..MD.WNELFKYPGVYVE...E...DGSFEVKIRSPYHRTPA..R...LLAGQSQRDMSSLN.FYAIAGPIAPSGETARLPIVVQIDEIVR..P.................................	0	0	0	0
+3490	PF03688	Nepo_coat_C		Nepovirus coat protein, C-terminal domain	Mifsud W	anon	Pfam-B_3589 (release 6.6)	Domain	The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure [1].	21.10	21.10	21.90	23.80	20.40	21.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.79	0.71	-4.61	21	412	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	28	141	0	397	0	149.10	66	26.03	CHANGED	hshsphF.sWhsl...sshpsss....hphpIPuRltDls........spsssVshtsNPhuhhhussGhHtGp.lpL+hpWsh.psphuptpGslthhphhtchupshsspstl......ssh.ssuhph.lphGsFuGssssu..shshhsc..altlphspucplppLpVslclhsGFpFYGRo	..SF..EDDYF.VWVDF...SEFTLDK....EEIEIGSRFFDFT........SsTCRVSMGENPFAAMIACHGLHSGl.LDLKhQWSL.NTEFGKSSGSVTITKLVGDKAhGLDGPSQl......FAlQ+LEGss-LLlGNFAGANPNo..HhSLYSR..WMAIKLDQAKSIKlLRVLCKPRPGFSFYGRT........	0	0	0	0
+3491	PF03689	Nepo_coat_N		Nepovirus coat protein, N-terminal domain	Mifsud W	anon	Pfam-B_3589 (release 6.6)	Domain	The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure [1].	27.30	27.30	27.60	28.80	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.56	0.72	-4.26	21	379	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	32	141	0	386	0	87.90	68	12.85	CHANGED	hsaspslplPp-sptGslLuplslhsthpshsuhsatcWlppG..hlpsplclhh+lssssFsGlolhhsaDAasRl.s.sshssshshshshsl	...LAGRGVlYIPKDCQANRYLGTLNIRDMISDFKGVQYEKWITAG..LVMPpFKIVlRLPANAFTGLTWVMSFDAYNRI.T.SRITsSADPlYTLS.V.........	0	0	0	0
+3492	PF00064	Neur	neur; 	Neuraminidase	Eddy SR	anon	Overington and HMM_iterative_training	Family	Neuraminidases cleave sialic acid residues from glycoproteins. Belong to the sialidase family - but this alignment does not generalise to the other sialidases. Structure is a 6-sheet beta propeller.	19.60	19.60	19.80	19.60	18.90	19.30	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.77	0.70	-6.40	7	29236	2012-10-02 00:45:24	2003-04-07 12:59:11	13	4	28530	235	0	16025	0	436.40	57	99.38	CHANGED	MNPNQKIlsluulululsllslLlpluslhlsls.hh+ttt....pps.ssps..p..Npslptpshsp.sshshhhs....ppspahs.sculCslpGashhuKDNuIRlGpp...uplhVhREPaVSCsPsEC+pFhLoQGshlssKHSNGTl+DRosaRsLhSs.LGpsPslhpo+FcsluWSuouCHDG+tWhsIsloGsDssAsAslhYsth.T-sIpSWu+sILRTQESpCVClsGsChhVMTDGsAsspAph+IhhhccG+Il+pp.lousupHlEECSC.YsppspVpCVCRDNWpGuNRPllpls.p.hsapstYlCoGlhsDTPRspDsshossCs.Ns.ssps....GVKGFuacpGss....sWhGRTISpsSRSGaEhlhl.sGhopssS.p.hp+QslVsspsWSGYSGuFh.hst.st.pChsPCFaVEhIRG+Pc.EppshWTSsS.lshCGsssphssWSWsDGAplsa	....................................MNPNQKII.TIGSlshsIuhlslhlQIu.llohhs...H.hQht....spsp......p..p..s........s........s...h....p...p..sh...s...p.......s...Y..ls...ss..hph.hs....hhu..hh.shsps.CsloGaA.aSKDNSIRlGup...GDlaVhREPalSCush-C+pFhLoQGshLNsKHSNGTl+DRoPYRTLhSs.lGpsPsshNo+hcslAWSuSuCHDGhuWLpIsloGPDssAsAslhYNGhlTDoIpSWpps.ILRTQESECsClNGoChsVMTDGsu.sGpAs.h.K..Ih+I.EcGKIVKospL.s.usshHhEECSC.YPc.tsplpCVCRDNW+GSNRPh.VshN.s.hphphuYlCSGlhGDsPRPNDuouSsssh.sPssppG..u.GVKGauF+.GNs....VWhGRThSpsSRsGaEhhhs.sGW.os.ssS.s.sh+QsIVshssWSGYSGuF..asp.st.sCIpPCFaVELIRGRP.c.E..pslWTSsS...lsFCGssushsshSWPDGA-lsh...............	1	0	0	0
+3493	PF02932	Neur_chan_memb		Neurotransmitter-gated ion-channel transmembrane region	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family includes the four transmembrane helices that form the ion channel.	23.10	23.10	23.20	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.56	0.70	-4.48	50	6256	2009-12-16 13:54:54	2003-04-07 12:59:11	11	81	288	162	3294	5277	71	169.90	20	43.13	CHANGED	lllPClLIohLohLsFaLPsDuG.pKsoLuIosLLohTsFhlllscplP.poShslPLlspYllhhhhlssh.lhhsllllNsphRsP.psHphsphl+phhl.phlPphh.....hhppsstshssspstptttstsh.h.................................................................................................................................................................sststtstsssssss.hphssplcpulpus...............paIupp....................................................................................h+pcsp..p.tpsWhhsutslDRlthhlFslshllsolsha	.................................................................................................................................................hhlPshhlsh..l..o....hl.s........Fa....l........s............c..u...s.................t+h.s...L...............u...............lo..s.l......Loho.s.....h...hh........hp..p.tlP......t..s......S......h..s...........h........s....l...........................h..h...............h.h..........h..........h..h..hh...l..hs......h.......l..................h.s..h.l.s.....h.............h....p..h...p....t.............t........h............h..............t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	922	1195	2303
+3494	PF02158	Neuregulin		Neuregulin family	Mian N, Bateman A	anon	IPR002154	Family	\N	20.30	20.30	24.60	22.80	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.50	0.70	-5.69	2	267	2009-09-11 01:37:10	2003-04-07 12:59:11	10	8	42	4	77	244	0	313.30	50	58.48	CHANGED	AEELYQKRVLTITGICIsLLVVG.MCVV.AYCKTKKQRpKLpDRLRQSLRpcppNlsNhsNtPHpP.NPPP.cNVQLVNQYVSKNVISSEHllEREsETSFSTSHYTSTsHHSTTVTQTPSHSWSNGhoEShIS.cS.SVIhhSSVENSRHoSPsG.PRGRLpGlGG..c.sSaLRHAR-TPDSYRDSPHSERYVSAMTTPARMSPV-F+TP.SPKSPs.EhSPP.SShsVShPSVAVSPFlEEERPLLLVoPPRLREK+YD+........pQhNSaHHNPuHpSoSLPPsPLRIVEDEEYETTQEYEss.EPsKKlsNSRRtKRTKPNGHIuNRLEhDSsoSS.SSsSESETEDERlGE-TPFLuIQNPLAASLEsAshaRhA-SRTNPsuRFSTQEELQARLSS	.......................AEELYQKRVLTITGIClALLVVGIhCVV.AYCKT....KKQ.RK...phHs+LRQs..hpsc+.pN.hhslANG..P..pHP.tsPs.E..plQhs.sp.YlSKNl...uo-Hllc+EsET..o..FSsSH.sSsu.HHso.TsTpT.s.....S...........H.......o.......WS.t+oESlhS.-SpS.slhhSSVtsS+psSPss..sRuR...hs...u...hsu.......c....c....ps..hh....th+-o.DShRDSP.HS..ERYVSA...hTTPARhS.......P.V-Fchs.....sspsPs.phosP.uuh.shS.hPshs.hs.h.h.t-pp..PLl..h..................................................ts.......................................................s.S.Pso.Ph+l..--..ph-sh......pph.ss.................p..........t......p...t+sp.sG.hu.c........sp.t..u.s.s.............o.........s-t-.-t...........uEsTPFLuhps............sh........tsRT........................................................................................................................................................................	0	2	9	27
+3495	PF03823	Neurokinin_B		Neurokinin B	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	28.00	35.90	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.91	0.72	-4.22	3	39	2009-09-10 23:24:23	2003-04-07 12:59:11	9	2	26	0	16	39	0	54.90	63	37.49	CHANGED	MRSsLLFAAILALSLApSFGAVCEEPQEQVVPGGGRSKKDSDLYQLPPSLLRRLYDSRs	......MR.hLLFsAILAhSLApSFGAVCcEsQEpssPGGG+SK.+DsDLYQLs..sl..LRRLacS+S..................	0	1	1	4
+3496	PF00243	NGF		Nerve growth factor family	Finn RD	anon	Prosite	Domain	\N	21.30	21.30	21.30	21.70	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.57	0.71	-4.36	7	3765	2012-10-02 16:54:34	2003-04-07 12:59:11	13	4	2066	24	107	2860	0	90.40	67	44.04	CHANGED	psht+RGEhSVCDSlSlWVT..-KpoAsDl+G+pVTVLs-Vshssus.hKQYFFET+C+ss.......sssssGCRGIDp+HWNSpCpsopoaVRALTh-spp.VuWRaIRIDTACVCsLopKoGp	.............................p-..su+RGEhSVCDShSc..WVT...-Kp.TAVDhpG.tpVTVLtcV...sls.put.lKQYFYETKCpsh..........................t....s.K.pG.CR.GIDt+a.WN.S.CpTopo....aV+AL..T.-tp.............................................................	0	12	21	45
+3497	PF02979	NHase_alpha		Nitrile hydratase, alpha chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	27.20	27.20	27.20	27.20	25.90	27.10	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.23	0.71	-5.02	37	386	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	295	57	122	382	231	157.00	41	86.98	CHANGED	sp.o-hthRspALEplLhEKGllssusl-thl-haEschGPpNGA+VVA+AWsDPsF+ttLLpDuoAAhtEl....GasGtp..G.........EahlsVENTsplHNllVCTLCSCYPWPlLGLPPsWYKossYRuRsV+-PRsVLt.EFGlsLPsssclRVWDSoAEhRYlVlPhRPsGTEGhoE-pLAsLVTRDoMIGsuls	...................p.....t.h.hAL.phL.tKGllsst.lcthhphh-pp.u.PttGAclVA+AWsDPsF+thLLtDusuAh.tp.h.....Ghts.p.G......................phhhslEsTsph+NllVCoLCSChsWslLG.LPPsWYKs.tYRuRhV+-PRtVLs.E.hGhplsscsclRVaDooA-hRYhVlP.RPsG.T-.shsp-tLttlVo+-shIGsu.........................	0	38	69	88
+3498	PF02211	NHase_beta		Nitrile hydratase beta subunit	Bateman A	anon	Pfam-B_5347 (release 5.2)	Domain	Nitrile hydratases EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile hydratases are composed of two subunits, alpha and beta, and they contain one iron atom per alpha beta unit [1]. 	21.30	21.30	21.70	21.70	19.80	21.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.69	0.70	-4.64	33	440	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	230	80	156	463	350	165.30	25	93.48	CHANGED	MsGsHDlGGhpGh.GPV..s.-....s.--PlF+t-WE+RAhulphAhsu..hGt.....................WslDpsRaAtEphsPs-Y...lpsoYYc+WltulppLhl-pGhlop-ELst.......uphhpsstshsp.slsA...-tVsshLtcGsPspR.sssssspFtlGDpVRs+.shsss.....uHTRLPpYlRG+sGplt.thaGsaVaPDosA.cGtGEs.PpaLYsVtFsupELWGss.ssssssVslDlWEsYL-sA	..................................................l....p........t..tts..sFpt.WEtpsaulhhshtt..hGh.....................ash....--......h......R.......h..........u....h.......E....p.....ht.....s.....t.pa.......h.t.hsYYc+WltulppllsccGllotpELtth...........t.....st.....................................................................p.l.h..............a.Rh..ah.th.G.l................................h.l......................................................................................	0	31	80	108
+3499	PF01292	Ni_hydr_CYTB		Prokaryotic cytochrome b561	Finn RD, Bateman A	anon	Prosite	Family	This family includes cytochrome b561 and related proteins, in addition to the nickel-dependent hydrogenases b-type cytochrome subunit.  Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a  prokaryotic family.  Members of the 'eukaryotic cytochrome b561' family can be found in Pfam: PF03188.	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.42	0.71	-4.89	84	1155	2012-10-03 10:28:09	2003-04-07 12:59:11	15	11	975	0	237	5046	1484	182.50	26	73.89	CHANGED	ta..shhhR...........hhHWhhAlhhlhhhh...oGhhhhhh..hhhhh...................................................................hph....Hhh..hGhshhslh.lh+lhht.....................................hptphPthhttsshtph...................hhhhlhhhhhhhsloGhhh.............................................stshtphhthlH..hhuhhlh.shlhlH.lhtslhpphh.t...slppMhsG	.............................................................................h.ashhsRlhHWssAlhhllLlh....oG.lh...h....s.h.h...s.h.s.h.st.h....................................................................hsl..........Hth...hGahLluhh..hhhll.thh..............................t.hhth..s.h.......t...t...h.t...p..h...h....h.h...h......h...t..l..h..p.....s..c..........t.....s...h....s....u...t..s.sph.....................hhh.l.h.as.L.l.sllllTGllhhh......................s.....h....................................hs.uh..t..h..h..hth.....H..hhlAhlhl..halhsH.l.h..hs.h.hs..ph.t...p.......hhcuMlsG...........................................	0	56	139	181
+3500	PF04097	Nic96	NIC;	Nup93/Nic96	Wood V, Finn RD	anon	Pfam-B_5541 (release 7.3);	Family	Nup93/Nic96 is a component of the nuclear pore complex.  It is required for the correct assembly of the nuclear pore complex [1].  In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1 [3]. The structure of Nic96 has revealed a mostly alpha helical structure [4].	19.10	19.10	19.70	19.50	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	613	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-13.15	0.70	-6.39	40	382	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	274	4	256	382	2	536.10	25	67.14	CHANGED	s.plh-tapths..............................sshcscpls-hWphlpphh.....................shpusshptpllpsu+paLEppahpalpshlt+s.pcAthtGhPsshs+lpualch+ltpts......sLt...l...supPlWsllaYhLRsGhhppAhchl....tpthpphcpsFhsahpsaspstsppLsschps+lptEasppl+ss.t............DPYKhAlYplI.....G+CDl....spp...shs.plspolEDaLWl+Lsll+pss.t.sps.......h-pasLs-lQshlh.paGpppFss......stps.hYaplLlLoG.FEtAlpaLhc.....hspsDAVHhAIuLs.huLLpsust.p.........pplLshssps......lNauRLlspYs+.pFchsDsptAlpYhhhlshhps...............ppth.shhpcslp-L.....lL-oR..-FshLLG.clpp.cGp+..hsGll-c.........lhthps.cp.hpplsppsApc..s-ccGphp-AlhLYpLup..............paDpVlsllN+hLupslspsst......................................stospsslhthApplhchYpsssth..p..lpspscpT.hplLlplhphhshappspappALptlppLs.llP.............ss.sp..lcctuppFps..lssplh+slPslLlhsMssltphhpplpssthss.tp................ppplspL+ppA+slh..haAuhlpY+hP	.......................................................................................................t...hhthhtth...............................tthp.ppp..hschWhhhpth.......................................shpshphphphlptuppaLEppahpahpshlhts.ppAthGG......hPsshp.......hl+ualpl+h.t.t..........tht....s....................pspslWsllaYhlRsG.hptAhphl...........pth..pp.....tpF..hshhppa.........hp...........s..................sppl...s..php..pp.lp.capptl+pss.........................DPa+hAlYpll.........GpCDh........sppp....tls.pshEDal....Whp...L....s.lp.ssts.p.s....................p.hsLtplQp.lh.ph.Gt..phFst.........ttp.hhah.lLhLsu.FEtAltaLhp.....h..scAVHhAlsLt.htLLthsst.p.................tthlshpstp.........................lN..hspllh.Ysp.pF.c..ssspt...AlpYhhhlp..ts...............................pt..phhhpslp-l.....llc..o+...pashllG..chp...cGp+.........h.Ghl-p......hts...t.hpplh.psAp...spppGh..hp-AlhLYpLAt.................................................ph.-pslplhsphL.upslst..t......................................s.sttpp.h.hAtphhphaptps...h........................hpt..pps...hhlLlplhphhs.hpst..p....h.tpA..l...c.lppLp.llP.............hs.tp....lcptsttaps..hsstltpslspllhhshphl.p.hp.phttst.ts..t.................pt.hppl+p.upslh...auu.l.a+h.............................................................................................	0	88	139	216
+3501	PF03824	NicO		High-affinity nickel-transport protein	Griffiths-Jones SR, Kerrison ND, Finn RD, Eberhardt R	anon	Manual	Family	High affinity nickel transporters involved in the incorporation of nickel into H2-uptake hydrogenase [2] and urease [3] enzymes. Essential for the expression of catalytically active hydrogenase and urease. Ion uptake is dependent on proton motive force.  HoxN in Alcaligenes eutrophus is thought to be an integral membrane protein with seven transmembrane helices [4]. The family also includes a cobalt transporter.	25.00	25.00	25.00	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.72	0.70	-5.09	20	2471	2012-10-02 18:22:22	2003-04-07 12:59:11	11	9	1720	0	612	1814	250	244.40	22	78.85	CHANGED	hhuhshLuashGlhHAh-.ssHhtAl...lpshhtsscssltsGhhhohupSslhslhulhlshushhltp.....hsthpphsuslth.lsusFlllluhhshhlhpslhchatt..t....stt.tsthpthhtt.....................................t.hs+hht.......h+.h.tpphHhhssG...u.G..susphthhu.sst...th.shshhshhsasslFuuGhp.ssuu.sllhhuhhshsahs..hhthhasholsGsulsluhhsshlhshphlAp+hshpss...hstlstls...hphlGhhllhlhulshlsuhlh	............................................................h.hhhhhhuahh....G....lhHAl.s.s.sHhtsl................ht.phh......h...........s..t...........c.....s.s.l...t..........uhh....hu....lutohhh..shhs.lhl..sh..sshhltp.................thp.thsu.t.h.hht...l......s.shll...llu.h..s..h.h.h.h.......ps.hh.p..hth.htt...............t.t...h..p.th.h.................................................................................................t.h.........................t.....h...p...c..ph+..h...h......h...u...............t...........p....s.sph.th...h.s.s.t........th............sh.s...h.....h....h.h...h....hhhssGh..h.sssh.sllh.h.sh...h...h......shsh....hht...hhhshsl.hs...hh.l..shhhshh...h.p........hs.t..+.h..s.h.ts....hhp..hhshhs.............hhGhhhlhhhh.hshhh....h...................................................................................................	0	143	336	484
+3502	PF00374	NiFeSe_Hases		Nickel-dependent hydrogenase	Finn RD	anon	Prosite	Domain	\N	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.84	0.70	-5.73	12	4820	2009-09-12 07:59:36	2003-04-07 12:59:11	14	9	1571	65	1336	3444	238	268.90	27	63.43	CHANGED	RGLEhILKGRDPRDA.tFspRICGVCThsHALASVRAV-sAlGIclPpNAphIRNLhhtuhhlHDHlVHFYHLpALDWVslssALpADPttsucLspslS.shsh.oss.h..csVQs+lKcFVESGQLG.FtNuYas..p.AYhLPPEssLhAsuHYLEAL-hQ+chschhuIFGGKNPHs.shlVGGss.sh.slDs..........cRL.s.hpuhhcclp-FlcpVYlPDllsluuhYKc..hhhtGGhs.pNhLu....aG-aPps.....hstsohhhPsGslhsushscVhsl....D.t..c...EaVpHSWYc.ss-.huhHPa-GhT-Ppashhs.................D-s.+YSWlKAPRa+G+shEVGPLAphlluhup....uc......pthcc.l-hhltths......lssstlaST..............LGRTsARulEsthssp.ht.hhccLhsNlpsGc.sss.sccW-.sphPppu+GVGhs-APRGuLuHWl+IKDGKI-NYQsVVPoTWNuuPRsspGplGshEtuLlsT.hscPcpPlEILRTlHSFDPClACusH	......................................................................................................................................................................................................................................................................................................RGhEh.lhpsR.....s.h.s.s.h.hh.spRlCGlCshsHshu.shuhE.....s.....A..h.....s......l...p......l.....P.......p......A.phlRslh...t.s.hhpsHhl...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	448	910	1161
+3503	PF04891	NifQ		NifQ	Kerrison ND	anon	Pfam-B_6173 (release 7.6)	Family	NifQ is involved in early stages of the biosynthesis of the iron-molybdenum cofactor (FeMo-co) [1], which is an integral part of the active site of dinitrogenase [2].  The conserved C-terminal cysteine residues may be  involved in metal binding [1].	19.40	19.40	19.50	19.50	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.37	0.71	-4.09	39	166	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	159	0	76	167	16	160.20	35	80.39	CHANGED	cshAsl..Luhuhtptt.tt.usls.hh.GLsssshssLls+aFP........s..thtsh.....sshsss.spE.spLpsLLhsc.....pusssstuthlAtllAptshtssHLWpDLGLtsRsELStLlt+aFPsLAutNspsM+WKKFFYRpLC.-p-GhhhC.puPsCstCsDastCFG	.....................................................h....thLuthhttht.t.stssl.s..t.h.GLsssphttLlsph.FP............................t..sthh..h..........sth.ssstspEhtpLtsLLhtp..............tuss..sststhlAtllActshtssHLWpDLGLtsRs-LotLht+aFPsLAspNsp.sM+WKKFhY+plC.cpcGhhlCpuPsCstCsDashCFG..............	1	20	43	57
+3504	PF01106	NifU	NifU; NifU-like; 	NifU-like domain	Finn RD, Bateman A	anon	Pfam-B_1206 (release 3.0)	Family	This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown [1].	20.90	20.90	21.00	21.60	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.17	0.72	-4.20	20	3818	2012-10-01 19:25:19	2003-04-07 12:59:11	12	19	2999	6	1182	2450	2182	69.10	37	38.36	CHANGED	lpcVl-c.lRPhLhtDGGDlELlcV-Gs....pVpVcLpGACuuCspSshTLpsulEp+Lp-pls.pslcVlsl	..................lctlL-p..lRPhLt.t.DGGc..l..pl..h..c..l..p..cs.......hV.h.l.ph.t.Gu.Cs.GCsu.ushT..L..KpGIEptLhpplP..p..lh.tV.........................	0	376	769	1014
+3505	PF01592	NifU_N		NifU-like N terminal domain	Bateman A, Wood V	anon	Pfam-B_772 (release 4.1)	Family	This domain is found in NifU in combination with Pfam:PF01106. This domain is found on isolated in several bacterial species such as Swiss:O53156. The nif genes are responsible for nitrogen fixation.  However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation. These proteins appear to be scaffold proteins for iron-sulfur clusters [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.44	0.71	-4.19	16	4872	2012-10-01 20:52:23	2003-04-07 12:59:11	11	21	4284	25	1274	2971	2268	125.30	35	78.48	CHANGED	tYo-KVhDHahNPRNsGsl-csss.......hsGpVGu.uCGDsh+LplKVctpsshItDA+FpTFGCGSAIASS.ShhTEhlpG+sl--A.hploNp-IActLut......LPs.KhHCSshup-AlcAAltsYcu+phps	......................................................YpphlhDHacN.P......+N..h..G.ph.-ssst........................suh..h.s..s..P..sCG..D.s.hcLpl.+....l.........s..c..............p.............s......h.....I.....pD......s..+Fc..s.hGCu.uhASo.ShhT-hV..c..GK.o....l-EA....t............l........p............p...s...p.l...h...pp.l.t........................ls....s...s..c....h.c...s...s.hLu-s..s.lh.sulsca.t+ht.s................................................................	0	441	833	1074
+3506	PF03206	NifW		Nitrogen fixation protein NifW	Bateman A, Mifsud W	anon	Pfam-B_2891 (release 6.5)	Family	Nitrogenase is a complex metalloenzyme composed of two proteins designated the Fe-protein and the MoFe-protein. Apart from these two proteins, a number of accessory proteins are essential for the maturation and assembly of nitrogenase. Even though experimental evidence suggests that these accessory proteins are required for nitrogenase activity, the exact roles played by many of these proteins in the functions of nitrogenase are unclear [1].\	 Using yeast two-hybrid screening it has been shown that NifW can interact with itself as well as NifZ [1].	20.60	20.60	20.80	20.70	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.43	0.72	-3.93	39	208	2009-09-11 15:38:48	2003-04-07 12:59:11	9	1	203	0	87	189	12	100.60	30	92.76	CHANGED	Mo.......hlcph.....ccLouAE-FFpahslsYDscVVsVsRLHIL++FspYlspt...sh..ssh.s-sthhsph+shLp+AYpDFlsS.oPhpc+lFKVap-tstp..........hVsLsslps	..................hhpcl.....ppLooAE-FhpaFslsYDscllsVsRLHILKRFspYLttt......c......th.spppthtthRphLppAYpc.FhpS.sshpp+lFKVhppt.............hVslstl..t...............	0	19	52	70
+3507	PF04319	NifZ		NifZ domain	Bateman A	anon	Pfam-B_6057 (release 7.3)	Domain	This short protein is found in the nif (nitrogen fixation) operon.  Its function is unknown but is probably involved in nitrogen fixation or regulating some component of this process. This 75 residue region is presumed to be a domain.  It is found in isolation in some members and in the amino terminal half of the longer NifZ proteins.	20.30	20.30	20.50	21.10	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.47	0.72	-4.60	41	240	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	176	0	121	231	7	74.10	42	68.32	CHANGED	t.PtFphGp+V+sp+slRNDGTaPG..pchG-lLVc+GshGYVhsIGoaLQphh.IYuVcFl-pGhlVGCRccELpss	....t..PtFphGp+V+up+sl+ND.....G..TaPG..pphG-lLl.++G-hGaVhslGoa..L..Qp.h..IYsVcF...h-....p......uh...l......V....Gh+ccEL.s.h...............	0	31	76	98
+3509	PF01077	NIR_SIR		Nitrite and sulphite reductase 4Fe-4S domain	Finn RD, Bateman A	anon	Pfam-B_1092 (release 3.0)	Family	Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully.  They are also both important for the dissimilation of oxidised anions for energy transduction.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null --hand HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.87	0.71	-4.87	91	15116	2009-01-15 18:05:59	2003-04-07 12:59:11	17	120	3409	86	2437	13876	917	143.60	20	41.54	CHANGED	susslRsspsssssshsptthhDs.........................ptlstplp......................tphpththPtKFKlulsG.........ssssCststsp.Dlullustcsth.................................................................................GaslhlGGthutp.ttsthhh......sah.t-.....p.lhphlctllphap........cps+t+p...Rlt.hlcch..Gh-cFtppl..tp.hsp.h	..................................................................htthps.hss..G...s..h.Cchs.shDs..........................................pshsttlt...........................t..h......s..p.h..p..p..h..t..h..P..t......K...h.+..h.....sluu..........Cs.N.s.C.ssst.sp.Dlu..l....lG....h....t...c...p....s.............................................................................................................................shplh.luut.h.s.......................................p...........................h....hh...t....h...h......................................................................................................................................................................................................................................................................................	0	719	1561	2066
+3510	PF03460	NIR_SIR_ferr		Nitrite/Sulfite reductase ferredoxin-like half domain	Bateman A, Dlakic M	anon	Bateman A	Repeat	Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidised anions for energy transduction [1]. Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.90	0.72	-4.35	174	13756	2009-01-15 18:05:59	2003-04-07 12:59:11	12	109	3391	98	2671	12133	911	66.90	22	18.80	CHANGED	htpps.t.h..hlplpls.s.....Gpl.ssp....phptluclu.....c..cau.t..upl.+lTspQs.l.ltslptpplsslhptLtph	..........................th......t....atlplphs..u.........Gpl.osc..................tlptls-lA.................c....cas..t......Ghh.+h.Tspps.l.hh..sspppplttlhptLt..s.....................	0	772	1683	2259
+3511	PF02665	Nitrate_red_gam		Nitrate reductase gamma subunit	Bashton M, Bateman A	anon	COG2181	Family	This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool [1].\	     It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit [1].  The nitrate reductase enzyme, EC:1.7.99.4 catalyses the conversion of nitrite to nitrate via the reduction of an acceptor.  The nitrate reductase enzyme is composed of three subunits [1].  Nitrate is the most widely used alternative electron acceptor after oxygen [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.44	0.70	-5.00	66	2225	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	1577	10	386	1081	183	214.50	41	82.12	CHANGED	ls.phLaslaPYlslslhllGohhRacp-QaoWpocSSQlLcp+.tL+hGSsLFHhGILslhhGHlhGLLhPpshhcslGlopthhph.hAhhsGuhsGlhsllGhslLlhRRlsssRlRtsoohsDhhlLllLhlplhlGLhohhhuttph.......-hshhhplusWhpulhshpPs..uphlsslshhaKlHlhhGhslFslaPFTRLVHlaS..sPltYLtRs.Y.lhRpRp	...............................................................................................N.FhasIaP..YlshslFllGshhR............Y...cYsQaoWput...S....S.....QhL..-.++.thh.lu.S..sL.F..HlG.......I.L....s..l...FhG.H..h..h......G.hL...sP.....c...h...h...h...p....s.h........l....s............p.....s...h.....p....h.......h.A..h....hhG..u......h..s......G..l..ls.L....lG....h.s.hLlhRR.l.h..s..t..R....V...............R.s....s..o....o....ssD..ll..lhhlL..llps..hLGLhohshospph............Dhs...h....hp.lss...W.......h.p.S..lh...o...F.p.s....s......uph.h.s.sV.s.h.l.F.+l....HllLGhT.lFhlaPFTRLVH...l...aS...sPl..p..YlsRp..Y.lhRpR..............................	1	127	252	327
+3512	PF02087	Nitrophorin		Nitrophorin	Mian N, Bateman A	anon	IPR002351	Domain	\N	20.90	20.90	21.10	21.00	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.31	0.71	-4.49	3	15	2012-10-03 08:47:39	2003-04-07 12:59:11	10	1	3	66	0	101	0	166.40	42	85.60	CHANGED	CSTNISPKpGLDKAKYFSG.sWYVTHYLDKDPQ.VTDpYCSSFTP+ESuGTVKEALYHYNuKKKTSFYNIGEGKLESuGlQYTAKYKTVDKK+sVlc-ADsKNSYTLTVLEADDSSALVHICLREGsKDLGDLYTVLoHQKDuEPSAKVKuAVTQAGLKLSDFVuTKDLuCpYDD.QFTSL	.........................CopNlpsKpshDKsKYFoG.sWYVTH.Y.L..D.p-P..p..V.T.D.cYCuuF.s.s.+.p...u...sG.p...V..K...E.ALY.HY.Nsc.scs...o.F.Ys...l...u..E..u..p..l....pS....sG.....KY.T..A..K..ap...pVDKct..c.clc.cs.s...t..s.pYT..h..T..lh-sD.D..S.p.AlV..HhC...h....p...cus...c...s....l..hsLY..s....VLsRs..c..s..sp..s.s.s.KVKsAl.s.psuLKLscFhssKs....sCpYDs.phh.............................................................................	0	0	0	0
+3513	PF00881	Nitroreductase		Nitroreductase family	Bateman A	anon	Pfam-B_481 (release 3.0)	Domain	The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.94	0.71	-4.42	141	16517	2012-10-02 14:48:17	2003-04-07 12:59:11	19	110	4534	206	3919	12487	3614	164.20	18	68.07	CHANGED	lppR+Sh..R.pFpsps......lsp-p...lppllpsA.................ph......uPoutsh....psh....chhll.p.......stchp.......pcltphhht.h..................................................................thtpthhtsAshhlhh..........................................ssptttthshh...ssuhsspshhL..sApshGlusshhusht.......ttt............lpchl.sls............tplh..hhlsl..Gh	...............................................................................................................................................................................pR+Sh..+..p....a.p.sp.......lsp-.p...l.p.p.l.l.p.su............................................ph............uP.S.u.t.sh............Qsa.............+hlll...p..............stct+...................................pclt.ph..h......t...............................................................................................................................................................................................thttthh.t.p.A....s..h....hl..hl..........................................................................h....h.s.t...p....p.......h.......h.s.h.h.......ss.uhsst..s..h....hl..uA.p.s.h..G..lus...shhsuhp...................................tpt..........lpc...hl....s....ls.......pp........hp.h...hhlsl..Gh...........................................................................	0	1261	2568	3341
+3514	PF05211	NLBH		Neuraminyllactose-binding hemagglutinin precursor (NLBH)	Moxon SJ	anon	Pfam-B_6567 (release 7.7)	Family	This family is comprised of several flagellar sheath adhesin proteins also called neuraminyllactose-binding hemagglutinin precursor (NLBH) or N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunits. NLBH is found exclusively in Helicobacter which are gut colonising bacteria and bind to sialic acid rich macromolecules present on the gastric epithelium [1].	24.40	24.40	24.50	24.60	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.56	0.70	-5.14	3	170	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	54	3	13	172	0	241.00	39	94.79	CHANGED	KKshLAluLuSLLlGCAhasulEsthPsctppppsspohE....osEhsh.LcFNYPl+ucQsPpNcHlVlLLcP+IQlSDNIsKsYpcKFccuLhLQlpoILE++GYpVlpF..pDcc-lshspKKKuaLVLcMcGpVuILEDlKhslc-ss........uLsc-clVDhSSGaVplNFlEPcSs-llHSFulDVSclcAlpcplcoT+ouSGGF.lsKThVHc.K-T.N+-DAI+KILN+hYAsVMp+hsKELTK+NlE+YcKsucEMKs+K	..................................................................................pKs.luhsluulLlusu.p...hht................................t.sh.hphsY.hpucp..s.tss+h..llLLcP.plQhSD.N.IsKsYpsKFcsuLhlQlppILc++GYp..V..lph...pDcs-lshsp..K+cuaLsLchsGplsl.LpDhKhs..l.pcss..........uhsctcsV.hSuGalplsFlEPpSs-slcSFslDlSclchhpc.....hlchp+o.suuGh....ls......s.......oh.....V.........Kts....NpsDAI+plLN+hYsplMpcls+cLTpKNl-pYcKssc-hKsp+.............	0	3	7	13
+3515	PF04170	NlpE		NlpE N-terminal domain	Mifsud W, Bateman A	anon	COG3015	Domain	This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway [1]. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes [2].	21.40	21.40	21.40	21.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.10	0.72	-3.59	17	993	2012-10-03 08:47:39	2003-04-07 12:59:11	7	4	912	6	119	541	17	87.20	46	43.00	CHANGED	YpGlLPCADCsGI-TsLhLppDGTahLpppY.s+csts.phsuphsWscsuspls.L.sstu-..tspahss-ptL.MLDppGphlpGpL	.acGlLPC.......A.......D....CcGI-...ToLhL.......c.......c.....D......G.......T..alhsEcY.LG......s.....+.-............c..P...s..o.F.suh.GT....W........s...c........s........u.......c.p......l.l..Ls.c..u...p..G.-....cs.....YY.+..s......p..s.s..s.LpML..Dp.-.Gpslpup.....................................................	0	27	68	98
+3516	PF04973	NMN_transporter		Nicotinamide mononucleotide transporter	Bateman A	anon	COG3201	Family	Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide [1,2].	23.00	23.00	23.00	23.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.33	0.71	-4.82	105	2756	2009-09-11 15:40:44	2003-04-07 12:59:11	7	3	2145	0	399	1643	528	184.10	26	82.74	CHANGED	shlEhlAslhGlhslhLsh+pslhsa.hGllushlYshlhapspLau-hhLplaYhh.hs...lYGWahWp.ptp...ptp......pth.lpphshpphhhhlhhhhlsshhh.uhlhp...pas.........push......Pal..Duhsoshullupahhu++hlEsWlhWlllDllulsLaht+Gl...............hhouhlaslahlhulhGah..pWp+th	.......................................hlphluslhGllslh.hsuct.+h.hsahhG....llsss....l.ahhlh........a........p........h.........p.........L.Yuphlhplaahh.hs.....laGaa..tWp..ptp......................tpp................tplph..+h.h...s.hpp.h.......hh...h...ls..l.s...ll.shhlh...shhhs...h.s............................ssh....................Pah....Duhhh.slSllA.hLh.s++.a.h...EpWlhWllhsllu.lslah.hpuh...............hshsh.Yhlahh.ulhGhh...Whp.t..................	0	104	221	319
+3517	PF01233	NMT		Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	25.00	25.00	25.60	25.90	22.60	24.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.00	0.71	-4.62	6	493	2012-10-02 22:59:21	2003-04-07 12:59:11	14	9	326	58	293	473	38	152.50	55	33.97	CHANGED	-GPIDK.hs.-cVppEPhsLsuGFEWsolDlsDctQLcElYsLLs-NYVEDcDAMFRFsYStEFLpWAL+sPGW+.-WHlGVRVppopKLVAFIuAlPssl+Vp..sKslssVEINFLCVHKKLRSKRLAPVLIKEITRRVNlssIaQAlYTAGllLPsPVoTC	.........................................shc..plcpEPasL.Pp.uFpWsolDls..s..pp.LcElYsLLs-NYVED..DDsMFRFsYS.-FLpW...........ALp..PPGWh.pWHsGVRl...........p.....p.....o.pK.LVuFISAIPssl+lh.....................cp......h......h.............+.hsEINFLCVHKK.LRSKRlAP.VLI+.....EITRRV...NLpuIaQAlYTAGlVLPpPVuTC...................	0	93	151	228
+3518	PF02799	NMT_C		Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	20.60	20.60	23.80	20.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.23	0.71	-4.92	39	510	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	331	51	298	486	34	186.00	47	42.34	CHANGED	EVGFStLsss.T.....hs+tl+hYpLPcpspTpG.LR.McpcDlspVpcLLpcYLp+F.cLs.hF.ocEElpHWhLs........pcsVlhoYVVEsss..t+ITDFhSFYsLPSTVlpss.pHcsLpAAY.FY.soss.................ppLppLhpDALIlAKp.hsFDVFNALslhDNphFLccLKFG.GDGpLpYYLaNa+sss.hss.............oplGlVL	...............................................-VtFSpLstshT.....hpR.ph+hY+LP..c.................s...s.............p..TsG..LR.Mc.+DlstVpcLLppYL.p.p.F.cLsPsh.scEElpH...WhlP.......................p-pll.oaVVE..............ss..............s....tclTDFhSFYoLPSolhpps...pHpsL+AAY.aY.sssp.............................................................................ssLhpLhsDAL.IlAKp.psFDVFNALslM-Np..pF.LccLKFG.hGDG.p.LpYYLYNa+sss.hts............................pplGlVh.......................................	0	95	157	236
+3519	PF02070	NMU		Neuromedin U	Mian N, Bateman A	anon	IPR001942	Family	\N	18.40	18.40	18.90	22.80	18.10	16.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.68	0.72	-6.91	0.72	-4.42	8	56	2009-09-11 14:39:29	2003-04-07 12:59:11	10	1	29	0	18	49	0	23.70	66	18.09	CHANGED	aKlDEEaQGPhuuQSRGYFLFRPRN	.....hcEEhQuPhssQSRGYFLFRPRN	1	1	2	5
+3520	PF03980	Nnf1		Nnf1 	Finn RD, Wood V, Mistry J	anon	Wood V 	Family	NNF1 is an essential yeast gene that is necessary for chromosome  segregation.  It is associated with the spindle poles [1] and forms  part of a kinetochore subcomplex called MIND [2].	22.40	22.40	22.50	22.70	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.15	0.72	-4.06	26	221	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	191	0	149	223	3	104.50	26	47.01	CHANGED	spsLcssppQhsphhpppspcEFspIhcERslpp+LsELDcllpcAccRpct.t.............................sshhcsLsPpcllcupLhsthppphspLspplpplpt-NppLtpp..lpphccp	.....................t.hpplhcphhppLppshpcEhpcIhcEpslpttLNcLDcllpEA+p.Rcp..t.....................................................................ss.hpsh.sPcphlpuplh....shh....hpttspLptplpphptpNtpLtpplttt+p...................................	0	35	71	115
+3521	PF02898	NO_synthase		Nitric oxide synthase, oxygenase domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.00	21.00	21.90	21.70	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.17	0.70	-5.79	8	836	2009-01-15 18:05:59	2003-04-07 12:59:11	10	23	543	489	206	694	26	326.40	50	49.70	CHANGED	sssRssE-LLspA+DFlsQYYoSI+RtpScAHhuRLpEVpKEl-sTGTYcLTpoELlFGAKpAWRNAPRCIGRIQWuKLQVFDARcsoTApsMFEtlCNHIKYATN+GNlRSAITIFPQRTDGKHDFRlWNsQLIpYAGYKpsDGollGDPAsVEFTElCIcLGWKP+pGpFDVLPLVLpAsGcDPEaF-.lPPELVLEVPlcHPcYcWFpELGL+WYALPAVSNMLL-sGGLEFoAsPFNGWYMGTEIGsRNhCDspRYNlLEcVAp+MGLDT+sssSLWKD+ALVEINlAVLHSFQpsNVTIVDHHoAoESFMKHh-NEh+hRGGCPADWlWIVPPMSGSlTPVFHQEMlNYhLpPuFhYQ.s-sWKTHhWK	.........................................................Lh.pAptFIpphYpp.....h+h.....t.p.hppRlc....-lphEIcpTGTYph...Ttp.ELlaGAKhAWRNus...RCIGRl.WspLpVhDAR.......cssstpthhptl..spHIphATN.pGpl.+..ssIT.IF.s..+t..sG.t..s..h+I.aNsQLIRYAGYc.p.....G.hh.GDPAsh-hTcls..c.LGWp.s...p...t..s.pFDVLPLlhQh.s.s.c.s.Pcha-.lPscLlhEVPIcHP....c..a.....h.hpcLs....LKWYAlPhlSNMhL-IGGlpa...suuPFNGWYMsTEIGsRN.......hsDstRYN...lLE....cVActhsL.....DTp.+.s..sS...................L..........WK.......D+ALVElNhAVLHSFp............pp.sVoIVDHHoAucpF.pa.cNEtp.ttt.s..ss..ucWsWllPP...lS.solTslaH..p.t.h..s.N.hh..hpPsFhYp......c..p...........................	0	54	88	134
+3522	PF02474	NodA		Nodulation protein A (NodA)	Mian N, Bateman A	anon	Pfam-B_2183 (release 5.4)	Family	Rhizobia nodulation (nod) genes control the biosynthesis of Nod factors required for infection and nodulation of their legume hosts. Nodulation  protein A (NodA) is a N-acetyltransferase involved in production of Nod factors that stimulate mitosis in various plant protoplasts.	33.80	33.80	38.20	34.30	27.00	23.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.39	0.71	-5.02	30	1084	2012-10-02 22:59:21	2003-04-07 12:59:11	10	1	856	0	23	753	0	170.20	67	98.03	CHANGED	MRSpV+W+LCWENELpLuDHlELu-FFRKTYGPTGAFNAKPFEGuRSWAGARPElRsIuYDu+GVAAHhGlLRRFIKVGplDLLVAELGLYGVRPDLEGLGIoH..ShRVMYPVLQcLGVPFuFGTVRpALcpHlpRhs.RpGLATIloGlRVRSTLsDVahDLPP.TRl.EDlLVlVhPIGRshSEWPsGTlIDRNGPEL	.......................................-H.ELu-FFRKoYGPTGsFNAKPFEGuRSWAGARPElRAIuYDucG.lAAHhGlLRRFIK..VGp......sDLLVAELGLYuVRPDLEGLGIuH..S..l.R.sMYPlLp-LGVPFuFGTVRpALcpHlpRhs.R.pGlATllsGlRVRSThs-la.DLP.P.TRl.ED.l.LV.l.VhPlu.RshoEWPsGshI-RNGs..............	0	2	9	12
+3523	PF01798	Nop		Putative snoRNA binding domain	Bashton M, Bateman A	anon	Pfam-B_1362 (release 4.2)	Family	This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) Swiss:Q12499 from yeast is the protein component of a ribonucleoprotein protein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex [1]. Nop56p Swiss:O00567 and Nop5p interact with Nop1p and are required for ribosome biogenesis [2]. Prp31p Swiss:p49704 is required for pre-mRNA splicing in S. cerevisiae [3].	25.00	25.00	27.70	26.40	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.53	0.71	-4.91	16	1302	2009-01-15 18:05:59	2003-04-07 12:59:11	13	19	497	30	857	1287	98	145.10	41	29.75	CHANGED	plpchscplhpLt-hRppLhcYlcs+MsplAPNLosLlGphVGARLIuHAGSLppLAKhPASTlQlLGAEKALF+uL+.....o+ssoPKaGlIapushIppussps+GKluRhLAAKsulAuRlDshucp.ss....hG..h+pclEpRlcplcpt	..................................................................ltphscp.llpLschRp....pLhpYLps+MptlAPNLosLlGp..h.....lGARLIu.+A.GSLtsLAKhPAS.T..lQlLG......AE..K....A.L....F...R...ALK........T+.s...s...TPK....aG..l.IYHush..........ls..p.u..........s....s.cpKG+..huRhLAuKsulAuRlDs....h....u..-......sss........s..............hG.ph+p.plEpRLchhp..s..........................................	0	299	489	709
+3524	PF02451	Nodulin		Nodulin	Mian N, Bateman A	anon	Pfam-B_2163 (release 5.4)	Family	Nodulin is a plant protein of unknown function. It is induced during nodulation in legume roots after rhizobium infection.	25.00	25.00	168.50	32.00	19.20	19.20	hmmbuild  --amino -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.91	0.71	-4.85	6	33	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	2	0	5	25	0	114.60	33	83.64	CHANGED	sEAYESP+FKKFVTcCoSHVuETCSssss.pspEAl+..psshGLuaCLFDSMEp..CLs-HpAulhs.....................................psplcshsshPsolp.....................................................................................................s...........tP............................................lLIpTlpFRTVL+TCS+VSARoCLTAPNVATSsLsACLtPShNQCVYPsu....s.sssssPPI	..............h..ss+hp+hlT.souHVsppCS.......ptt.h...s...huhphhspM.t..Ch..atsth...............................................................................................................................................................h..hhphpsshthCo..oAp.ChssssVssSsL.th.hs.hppClY..................................	0	0	5	5
+3525	PF01189	Nol1_Nop2_Fmu	Nol1_Nop2_Sun;	NOL1/NOP2/sun family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.53	0.70	-5.03	10	8954	2012-10-10 17:06:42	2003-04-07 12:59:11	12	43	4410	23	2832	7258	1507	238.20	24	57.46	CHANGED	llpsssspsshslRsNspKtsRcshtpsL-ppulshpsluphsps..hshcpssulssLPtapsGashlQstSu.hsshhLsPpsc-t.............ILDhCAAPGGKToalsplhhp.pupllAsDhsppRlpplhsNlpRLGspshhlp...sDssc.tptssss......FDRlLLDAPCSusGsIc+cPcl+hhRp-pDItplspL..Q+cLLputh-hl.................KsGGhLVYuTCSltsEENpt..........sIchaLpc+scs-Lsspshscsht.ht.........hlphshphhP+ppstDGFFhAcLp	....................................................................................................................................................h..t..............t......t..............................h..............................................................................................................................................h......tt.....h...s......t...a....t.p......G......h...h...hl.Q.-tuo....h..s....s....h....h.....L....s.......s....p....s....s..pt.......................................................l.LD..h..C.......A......A......P.........GG.......K..............T............s........p.l.........s..........p...................h..............h............t...............t......p.................G..........t...........l..........h....A...........-h..s...t.p.R....l...p..h..l......t........p........s........h.....p........R......h......G.....h......p.......s...h......h.....ht............t-..u..t.......p....h............t..h..h...tt.......................................FD+...l...Ll..D.A..P.CS....G.........G....s........l.......R.......+..........c..........P............-..........h...............t.........h.......h..h...........p.............p......p.........h.......t.....p...l.sph...........Qtpl.Lptsh..phl.............................................+..s...G.G..h..llYuTCo....h..pEN..pt........................................................lp.h...h.....L....p.....p...t..........t.....h.....p.......................h...................................................................................................hp.h..P....t..........................-.uhhhs................................................................................................	1	951	1651	2323
+3526	PF04135	Nop10p		Nucleolar RNA-binding protein, Nop10p family	Kerrison ND, Finn RD	anon	COG2260	Family	Nop10p is a nucleolar protein that is specifically associated with  H/ACA snoRNAs.  It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA  snoRNAs (H/ACA snoRNPs).  Nop10p is probably necessary for the stability of these RNPs [1].	22.40	22.40	23.40	30.30	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.75	0.72	-4.23	44	426	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	393	22	298	416	50	51.40	49	80.10	CHANGED	hchhl.csstpc......lYTL+..pss.sGp.TtsuHPARFSP-DKYu+YRltlK+Rhs	..............hhahl.sssGpR......lYTLK........Kss.sGp......TpSAHPARFSPDDKYS+aRlslKKRa......	0	95	170	244
+3527	PF05048	NosD		Periplasmic copper-binding protein (NosD)	Moxon SJ, Bateman A	anon	Pfam-B_5499 (release 7.7)	Domain	NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ) [1]. This region forms a parallel beta helix domain.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.36	0.70	-5.21	120	1281	2012-10-02 14:50:22	2003-04-07 12:59:11	8	160	695	0	642	3494	729	202.70	19	40.37	CHANGED	hsNshsusshhh............sGlhl.ts............ssshl.....psssltpspsul...hhttupssplpsN....thpss.....thGlphhtuss...........shlpsNhhpssp...........tGlhlhsop....tt.slp.....sNplpsspt.......GI.hLptuss.......sp...lpsNpl...................ssspGlhlhsu..........ssNsls.sNplssN............shGlh...................hssS.......ps.....NplasNhF.sNs.slphssst...........sspW................ssst.................GNaW.uch.sG.........tD.tsuDG..IuD...s....sY....phs..ssh....DhlPLhtst	...............................................................................................................t.....................................................................................h..............t..h............t.sul............hh..t.s..p..p..sh.l..pss...........thpps..............phG.lp...h.h...sss..................shlps.N.h.h.ps.st................sG..lh....lhtss..............ps..plp..................sNthtssps..............Gl..h.l....p...t..s..s.s...............sh......lps.N.p.l...........................................t..ss.....s.....p.....G..l.h.lh.su..................spsplp....sN.p.hp.ss.......................t.h.Glt......................................hs.s.u..........ps..............Ntl.h.t...N.t...h...s.N.....t....h...........................................................................................................................................................................................t...................................................................................................	0	208	429	517
+3528	PF04054	Not1		CCR4-Not complex component, Not1	Wood V, Finn RD	anon	Pfam-B_13503 (release 7.3);	Family	The Ccr4-Not complex is a global regulator of transcription that  affects genes positively and negatively and is thought to regulate  transcription factor TFIID [1]. 	22.50	22.50	32.10	23.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.29	0.70	-5.60	30	447	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	288	0	299	459	11	319.90	38	17.68	CHANGED	sLLh-hs........ph.pshpspph....tphhpsFuphhptLpPhthPGFsFAWlpLISHRhFLP+lLp.hspppGWshaspLLhsLl+Fls.al+ssp.lscslpllYKGsLRllLlLhHDaPEFLsphHaphCssIPssClQLRNlILSAaP.+sh+LPDPFsssLK.l-hLs-hppuPplht..s.stsLps..tlKKslDsaL+t.tsssshlpplhst..lhhsppctt......sssphNl.......pLlNAlVLalGhpAlsphpppspssshssps..sthsllppLhpcLcsEsRYhhlsAIANQLRYPNsHTHaFspllLplFs.p.....sssppsIQEQITRVLLERlIVN+PHPWGLlITFhELlKNs.pYpFachsFl+ss.PEIcplFcsls+s	.................................................................................................ht..................t.t.......phh.sFspthphLpPhthPGFsauWLpLlSHRh..FhsphLt.............h......s.p...p.p............GW.shatpLLhsLhcals...saL+...ss...........p.....lspshphlYK..GsLRl.LLlLhHDFPEFLs-aHathCssIPssClQLRNlILS..Aa.P.cs..h..+L..PDP.....F..sssL.K.l..........-hLs..Eh.p...sP.plhs..shsssl.......thKp.lDpaLps.....tssssh...l.pp..lpptl.hs.pt.....................sssphNh.................LlNALVLYlGhpAl........tphpp.................pst....s.....s..............s.hs......s.....s...................sths.lhppLh...hpLcsEuRYhhlsAlANQLRYPNuHT+aFStslLhLFu................psppptIpEQIsRVLLERLIVpR..PHPWGLllTFhELl......+Ns.tapFaph.Fl+su.P.ElpplFpslhp.s.............................................	0	116	177	255
+3529	PF00066	Notch	notch; 	LNR domain	Sonnhammer ELL, Bateman A	anon	Swissprot_feature_table	Domain	The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR [1] and was shown to contain three disulphide bonds and coordinate a calcium ion.  Three repeats are also found in the PAPP-A peptidase [2].	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.82	0.72	-3.69	53	1456	2009-01-15 18:05:59	2003-04-07 12:59:11	12	302	120	25	783	1259	39	37.40	38	5.70	CHANGED	p.hppCs..........ttCtpph.usGhCDpp..CNshsCtaDGsDCs	.........................t....pCt..........ttC.tsph..uDGhCDpt..CNsttCtaDGsDCp.	0	251	317	518
+3530	PF03000	NPH3		NPH3 family	Bateman A	anon	Pfam-B_1584 (release 6.4)	Family	Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay [1].	20.60	20.60	21.40	20.80	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.58	0.70	-4.87	51	658	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	36	0	421	661	0	228.20	33	41.97	CHANGED	pD.WWhEDl.stLsl-hacR.llsuh+u+..slpsclIupuLhtYAp+hLssh.............................t.sss.sppcp+tllEoIlsLLPs.c+ss....l...ospFLhtLL+sAhhLsuut...ss+pcLE+RIGhQL-pAol-DLLIPu.........hssp..........slYDVDhVpRIlcpFlpp..................t.........................................t.tt....ts.stsshhpVuKLlDuYLAElA.sDs.NLplsKFhuLAE...slP-tAR.hcDGLYRAIDlYLKsHPtLo-sE+c+lC+lhDCpKLShEAC	...........................................................sWWh-Dl.s.Lplshap+.llhuhcsp...sh.......p.ph..lutslhhYAp+h.L.sh..................................................................t..ss....tptcp+hllEslls...lLPs..c+ss...................ssspFLhtL.L+sA.hhlpsu....ss.+tpL.E+RluhQL-pAolsDLLlPs............ssp................shaDl-hVp.Rll...ptFltt................................................................t...ts..sstsshhpV...u+LlDsYLuEl.A..D..s.sLphsKFhsLAp...slPc.AR....hcDGLYRAlDhYLK.....s....H..P..tlsctE+cclCp.lh-spKLS.-As......................................	0	54	267	350
+3531	PF03116	NQR2_RnfD_RnfE		NQR2, RnfD, RnfE family	Mifsud W	anon	Pfam-B_2882 (release 6.5)	Family	This family of bacterial proteins includes a sodium-translocating  NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium  pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting  (by an unknown mechanism) the transcription of the transcriptional activator ToxT [1]. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted [2].	22.90	22.90	23.30	23.60	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.05	0.70	-5.24	169	2456	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	1700	0	519	1837	989	327.80	35	93.22	CHANGED	shhspsuPHl+ssh.shp+lMhhVllAhlPuhhhu.hahaGhts..................................................................LhhhlluhlsulhhEslhtplRp+pl...h.DtoslVTulLlAlslPsshPhWhlslGssFAllluKplFGGlGpNhhNPAlsGRshLhh.uaPspM.os....Ws...................s.............s........Duh....osATPLshhpss.......................h........................p..hs.......hhshFhG.h.........GulG..EsSsLulLlGGlhLlhp+lhsW+Isluhlsuhhlhuhlhthh...s.............s.ht.hsshaHLlsGGhhhGAhFhATDPVouuhTs+G+hlaGhhlGllshlIRsau.uYPEGlhaAILlhNhhsPLIDa..astspshu++	......................................................................h.hhtsusas.+.sth.ssp+lMhhVllAhl.Puhhht..ha..a.G.hts......................................................Lh..hhl.uhlsulhhEslh.h.............pl.R.++.....pl..............h....-...tus.l.......lTulLlAlslPP.......hh..PhWhsslGssFu....llluKpl.a.....GGlGpN.hNPAh.sGhs..h.Lhh....u...aPspM...ou.......Wh....................................s................................hDGh....otATPLsthpsu................................................htt........hs........ptht.....hh.shahG...ls.......GuhG...Eh..ssL.AhLlGG.l.hLlap+.lhpW+...Issuh.l..lsh..hlhuhl.hthhu........................s.hh..hsshhH.LlsG.u.....hhlGAhFhATDPVouuh.Ts+G+hlaGhLlGlhshlIR...shu...uYP..-..G.....lhaAlLluNlhsPLIDaash.+shs+................................................	0	174	339	445
+3532	PF01566	Nramp		Natural resistance-associated macrophage protein	Bashton M, Bateman A	anon	Pfam-B_624 (release 4.0)	Family	The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains [5]. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis [1]. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria [1]. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis [1]. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals [1]. The yeast proteins Smf1 and Smf2 may also transport divalent cations [3].	29.80	29.80	29.80	29.80	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.11	0.70	-5.66	126	5115	2012-10-03 01:44:59	2003-04-07 12:59:11	13	22	3156	0	1386	3862	534	343.50	27	78.31	CHANGED	hATslpAGupaGYpLLWlllhuslhshllQthuA+LGlVTGc....sLuphh+cca......s.phhshhhhhhstlushAsslAEllGs.AluLplLh..s.......lPh.........hhusllsuhsshhlLh...ptu.a+hlEtllhsLlsllslsFlhplhlspPsh......splhtGhl.Pshss..........sslhls.....lullGuTVhPaslaLHSullp.s+t..h..............................pt............l+hsph.Dsh.lul.sluhllshulllhAAusha.....tstt..tl........................sslpsAtpsLpP........lhG..hA...shlFuluLluuGluSshsushAGthlhpGhl.phchsh.h+h.hsp.hthhsshhslhhhussht............hLlhSQ...VlhulhLPhsllsLlhhsss+p.....lM.G.pasNsh	............................................hoshtuGu.paGY.t.............L.La.l.ll.lu.slhuhllQ..............hhuu+.L...Gls.T.G.t............sLuch.h.p..c....ph.............................s.p.h.h.....sh.....hh.h.....l.....hstl.u..h.....h...........Ao..s.l......u..E..................l.l.Gu....A....l...u..l....p.l..Lh...u.............l.sl......................hh.Gs....ll.Ts.ls.sh...l.l...L.hh..................p..........t..........G......h+hl.Etl...lh.sLl.h.h.....lh.....l..s..a..h..h..t..l..h...h....u.....p.....P..s...h.........s.pl.h.....p..Gh.l...Pp.h.h.............................tslhhs.........................lul.l..G.....AT.l.MP....H...s..l...a.LaSulsp.s+t.hst.....................................................................cp........ptlphsp....h..D.ss.lul....hl.u....h.h.l.N..h....slll....huAushh.......ssts....sl...........................................................................................ssh.tp..sh..ps..L....ps...............................hh....G.....hu......shlF...u.lu....LlAuGhsSol.su.........o..h......uG..p...hl......hp......G.hl......p....h......c.h...s.....h......h..............h............R....p.........h.l............T..........h....hl.....P..s....h..........l.l..h.h.h.hs.ssst................................lL.l.h.u.Q......Vlh.u...h...t.L..Ph.sl.ls...L.lhh..o.s.pcp..lMG.phhs..h............................................................................................................................	0	404	819	1134
+3533	PF03813	Nrap		Nrap protein	Bateman A, Wood V	anon	Wood V	Family	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	22.90	22.90	22.90	23.50	21.70	22.60	hmmbuild  -o /dev/null HMM SEED	972	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.00	0.70	-13.73	0.70	-7.02	26	425	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	280	0	303	441	12	679.90	22	81.89	CHANGED	SauL+Tulp.p.psh..slDlslTMPcplFpcKDYLNaRaaaKRAaYLAhlAttL.....ccsts.thplpasahssDsLpPlLhlp...Ppsppssc...hco+....hpIpllsuhPpslFs.p+LLPs+NsIRsspssp.............PTPaYNuollo-sshstYhKhLapst+....ps-uF+DAClLGRlWLpQRGFuSuhpp....GGFGsFEauhLhuhLLpG....G......G.pGpplLhpuaSSYQLFKuslpaLAspDL.tppslhhsuss..............httshpsPslaDssptlNlLhKMoshSYphL+pcAphTLphLN-stpDpFstlFltKhs..shh+aDtllcl...............sphssspplphhphps.......h..plaplLc+AL.....G-RlphIplp..tpsppsaslpp+hsspttp.......slplGLllNP.ccsp+lVD+GPuu....EcccEutpFRpFWG-KA-LRRFKDGSIpEolVW...Ss...ssptsIlppIlpYlLcpHlphs..scclph....hucpFcphL..s..............shsssstsuFtsltcAFssLpKslpsl-.tLPLsl+pltPsussLRYoulp.PhPh................tsssh..-VllQFEoSu+WPD-LsAlp+TKsAFLLKIu-pLp.sss..hpshlsh-pp...hshthstshLsllpspGasFRLRlhp-REpsLhcRtlt........ssssptK.tpst.shhtac+pahtsP+HTpslpsLsp+ashaSPTlRLhK+WhsuHLL..ssHl.s-EllELlsl+sFlpPhPassPuSspsGFLRsLpFLucWDWpp-PLllDls.............................scLstpphctIpppFpshRp..DPsh..sp...sshFVAoc.D..ssGlhWo.....ptsshslAsRlTuLAKuAh.pllc....ppGh.............phslspLFpsuLpsYDFlIpL+sp.slpspps................ssspFKNL..pp..stsp....hsp.....tsshc.h.taVc-LptpYu....ssllFFps.........spsssVIuGLWs.Pphhps+sa+lshshsspPhs......................s.cpVpl..N+-AllsEIupLGs-LlpsI-s....p	.....................................................................................h-h.l.hPtthht.cDhhs.ph..KRshalthlht.l............................................th....tht.....ttp.h.s.l.l....................t..............................................lplh.s.........t....h...t..........+h..s.t.......t...ssl........+.................................t.............................................sTPhYNt.lh.p......h......phh.th............t...thtpuhhLh+hWhpp+t.......h..t................................tshs..th...h..sh.....hh.hLhpt...................................l...hs....shphh+.hh......hlu..t..p.h.....t.h.ht...............................................shh.c..t.hNlh.phs...ht............l.p..t..A.t..sh.h.h.pt............s..t.....F....t.hhh......................taD.hhpl...................................................................................l.thltpuL.......spRhphl.h........................................h.h..ttt................................l.lul.h.ps.tth.ph..lphGP.s......................pt......tuttF+pFWG.t.+.upLRRFpDGsIhcs.................hlW....................p......tt..l.t......plhp.ahL..thH..h........tptl...............t.hp..h.........................................s.t.....hhpsapplt.................p.l.t...........hp.......lPLplttl.shts.hRhsp...s.s........................................................................................phh..hph-tSspWPpph.ulphh+hAh.l.pltc.Lt.t......................................................p...t.....hplh.h....p......uhhF+h.lhhth-....hh.t...............................................hp..h...s.htthlpsht.....t.pa...hussh+lhKpWhtsp.hh........hh..tp.h-Llsh.ha...........h.............p............................s..................Pt....................o..suFh+hL.hlupasWp..pPl..ll..shs.............................t.php...tp..tltpth.t.Rt...........................hhlso..D...................ts.....hao.................t..s...lhtphh.lA.ttu.h.thlt........t.................................ph...t.....lF...h...ssht.a.Dh..ll.lp.t.....t..............................................................................h................................................hp.......hht...Lp.....at........t.hhh..t...........ttt.lshhh..............h.t..................................................................................t..........................................................................................................................................................................	0	118	180	266
+3534	PF03916	NrfD		Polysulphide reductase, NrfD	Finn RD	anon	DOMO:DM04466;	Family	NrfD is an integral transmembrane protein with loops in both the  periplasm and the cytoplasm.  NrfD is thought to participate in  the transfer of electrons, from the quinone pool into the terminal  components of the Nrf pathway [1]. 	20.30	20.30	20.30	20.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.25	0.70	-5.02	13	2377	2012-10-01 19:35:38	2003-04-07 12:59:11	9	13	1174	0	635	1611	579	296.60	25	81.36	CHANGED	ssstphssl...sWuhslAh.YhFll..GluAG..ulhlAhhh....chhptp..ttt..s.s...tl.lpsusll.uslsll.h.ullhllhDLs.RP..+Fhthh.h...asF..o...Shhs..h.Gl..hhht..sahslll...laLhhhhct..pltsht......h.s...........ht.hlt+....lhsl...u...........tthsp..sltllh.hlhAlhluuhTGaLlSslhuhPhhpsslLPs.hFlAuuhuSG...lAs.hllshll.hs+hps.csp.ssthlpphthhl.hht..phhlLs......h....hhV.G..hth.......ssstp..hpuhps...A..........Lpu.hh...s......hhFhlGlshlGlhlPllLt.h..hlsc.lptshshl.lhuulhsLsGshhhRahllhsG.hh.lu	..........................................s....h.tsh..sWs.h..IAh.alalh..Gl.u..uG..uh.h.l.Ahhl..................hh...apht.......tht....s.t.......hl..h+.s.s.hl......h...u.h.h.u.lh..l..Ghlhl...hhc....l............s....R..........Pa....ph....h.......h...h.....h....h.........h..h.......s.......a........s..................Sshs...h..ss....hhhs........lY.h..s...l.hs.....la.hhh..hh..t....cl.h.tht............................................................lp+........h....hth.....................................................thhh....hlts.ls....hlL.u.s....hl..tuh..sG..hL....l..o..u.h..h.s..h.....P......h......W..p.....s........s..h.....hPs..LF.l..hou..h.uG...h.uh...slh......h.h....h..........l.....t.........t...........p.hp...........s.....p..........s.....-....t............p...h......l...t..th......hsh....lhs....tl.hl.lh.....................s.......h...a...l...s......lth.............uss.t..h......hp.th.sh.....s...............................................h.s.u..s..h..a.........s.................hhF..W.l.t.l.l..h.h.s..h.l..hP..l...l...l......h...........hh.....s+...h.....p.p.s..h.t....h....l......h...hsu.h....h...sLlGs.h...h.h.R.h.llh.s..............................................................................................................	1	251	451	567
+3535	PF02723	NS3_envE		Non-structural protein NS3/Small envelope protein E	Mian N, Moxon SJ, Bateman A	anon	Pfam-B_1913 (release 5.5) & Pfam-B_7381 (release 8.0)	Family	This is a family of small non-structural proteins, well conserved among Coronavirus strains. This protein is also found in murine hepatitis virus as small envelope protein E (e.g. Swiss:O72008).	25.00	25.00	27.80	27.60	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.91	0.72	-4.06	12	303	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	234	0	0	157	0	78.20	35	97.76	CHANGED	M.h..slhhh-ssshVlshllhhllhllhLllslAhLshI+LChpCsshsNshlhtPshalYs....hYpsa..clpP.ss..s.l	......Mh..shsht-TsshVlshlhlhLlhllllllslAlLssl+LChhCCslsNshllpPolYlYs+s+phYpsa..phps.................	0	0	0	0
+3536	PF02071	NSF		Aromatic-di-Alanine (AdAR) repeat 	Casavant T, Bruckert F, Bateman A, Mian N	anon	IPR000744	Repeat	This repeat is found in NSF attachment proteins. Its structure is similar to that found in TPR repeats Pfam:PF00515.	27.00	1.00	27.10	3.10	26.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.98	0.77	-6.20	0.77	-2.28	51	10	2012-10-11 20:00:59	2003-04-07 12:59:11	15	2	2	0	5	284	6	13.00	28	22.38	CHANGED	AuptappAupha	.....AuppYpcAAcha......	0	5	5	5
+3537	PF05064	Nsp1_C		Nsp1-like C-terminal region	Wood V	anon	Pfam-B_3555 (release 7.7)	Family	This family probably forms a coiled-coil [2].  This important region of Nsp1 is involved in binding Nup82 [2].	22.50	22.50	22.50	22.50	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.49	0.71	-4.45	30	353	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	282	2	233	349	0	113.90	30	21.20	CHANGED	ssspssp.sssss........LcsKsL--lIsKWop-LscppKpFppQAspVspWD+hLl-NG-cIspLassshcsEpsQscl-QpLpalcsQQcELEphLssYEpchcplh.sph..sps.......stc	........................hs.....t...ssss.s.........hphppL..--lIs+Wsh-Lpcpp+cFhpQAspVssWD+hLlcNGc+IppLap.cstcsctsQpcl-ppLshltsQQcEL-shLsshEcplcp...sp........................................	0	80	128	189
+3538	PF03146	NtA		Agrin NtA domain	Bateman A	anon	[1]	Domain	Agrin is a multidomain heparan sulphate proteoglycan, that is a key organiser for the induction of postsynaptic specialisations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino terminal (NtA) domain [2]. This region mediates high affinity interaction with the coiled-coil domain of laminins. The binding of agrin to laminins via the NtA domain is subject to tissue-specific regulation. The NtA domain-containing form of agrin is expressed in non-neuronal cells or in neurons that project to non-neuronal cell such as motor neurons. The structure of this domain is an OB-fold [1].	20.80	20.80	20.80	22.80	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.79	0.71	-4.49	2	48	2009-01-15 18:05:59	2003-04-07 12:59:11	10	18	29	4	20	43	0	116.40	73	11.37	CHANGED	TCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDlVApESLLDGGNKVVIuGFGDPLICDNQVSTGDTRIFFVNPAPPYhWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKP	.....CP.E+sLE..+REEEANVVLTGTVEEIlNlDPVp..pTYSCKVRVWRYLKGK-l......Vsp....E.sL.LD...GGNK...VVIGGFGDPLICDNQVSTGDTRIFF.VNPAP.YhWPAHKNELMLNSSLMRITLRNLEEVEaCVE-K................................	0	7	8	13
+3539	PF02136	NTF2		Nuclear transport factor 2 (NTF2) domain	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR002075	Domain	This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.45	0.71	-3.72	43	1695	2012-10-03 02:27:23	2003-04-07 12:59:11	15	45	499	189	981	2094	108	119.60	22	36.72	CHANGED	luptFlppYYpthss.....c.ptlsphah..t-sShhshsGp................thpGhpsIscphtsLshsp......h.ptplsslDsQ.......ss.ttslllhVsGplpsssp..h...ppFsQsFhLsspp....tsaaVhsDhaRh	................................uptFlp.pY.Yphhsp...........sh....p.t.LtphY.........tcs..o.h..h..sh.tsp......................................................shp.G..tp.sIt....c.t.h...p...s.L..s..hsp.............h..phpl.p.s..lDsp...............................sshpssl.ll.V.sGtl..............p....s..sp..................hpFsQ..sFlLssps..........ssahlhsDhhp...................................................................................	0	254	446	711
+3540	PF00483	NTP_transferase	ADP_glu_Plase;	Nucleotidyl transferase	Finn RD, Bateman A	anon	Bateman A	Family	This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.68	0.70	-5.08	64	22811	2012-10-03 05:28:31	2003-04-07 12:59:11	18	112	5108	164	5670	20398	12452	242.50	22	69.14	CHANGED	tulILuGGsGTRLaPLT+shsKphlshhsp...shlphslsslh...uulpc.lllsspppphhlpctltcssphu.........lplphshpstsc.........GoAsAltlut.hltppps......hLlLuuDtlhp...satphlppttspss....ssohhhhsspssotaGllchs......sst......plhpFhEKPptsp.....................sshsshGlYhassslh.hh.p..lpp.tctcspls-hhtthlcpsphshshhhps...................................WpDlGohcula-usttltpt	.........................................................................................ulIh.Au.G...h..G..T.R..h......h.......P....h...T........c....s..........h.......s..........K......t...h.l......s......l........s...........s.......+....................s...........hIp............a.sl....p...p...h.......h.......t............u..............G.....l.....c....c.........l.....l.l....s.....s...t.........t....p.........t.........p...t.....l..p...c....h...h....s...p..s.......p..ht......................................h..p.l.t.h..h...h...p..s...p.st.........................G..h.u...p..A....l...h...h..u...t..t..h..l.ssps...................hllL.s....s....D....h...l..h.s.......................sh.p...p....h...l........p.......t.........t..........t....p...p...s.....t.....................h.....s..s.............h..h..h......h........h....p...p....s...p....t...a...G....l..l...phs......................................pps..........pl...h...p...h...h...E....K.....P..p....t..s.p........................................ssh..s..s....s..G..hY....h..h.s..s..p..l.....h...........h..h...........p............................p.................t.........t.....t.......s......c........................h....p.......-......h.....h........h...h......h...p....p.....t...p....h........h...t....h...hts........................................................................................................h.D.hG.s....htshhph.......th...........................................................................................................................................................................	2	1857	3653	4776
+3541	PF05014	Nuc_deoxyrib_tr		Nucleoside 2-deoxyribosyltransferase	Bateman A	anon	COG3613	Domain	Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides [1].	27.80	27.80	27.80	27.80	27.70	27.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.36	0.71	-4.20	107	1106	2012-10-02 19:28:18	2003-04-07 12:59:11	10	7	886	35	291	866	351	125.70	22	73.25	CHANGED	lYLAuPh.Fs..t..sphphspchpphLpphuh....psh.hPh.............ptph......s......s.thuptlaptslptlcpuDsllAs.ls.shc......sDsGTuaElGaAhAhsK......Plhshps-hc.........................................p...thshNLM	.....................................lYhAush..Fs....t...tp....hphh.p.p.lhphlcptsh..........phh..hPh..................ct.ph........tt.........tshttsptlhpsDh.pt.lppuD.lllAh.ls..s..........DsGouhElGhA.hA.h.....s.K......Pl.l.s.hhpstp......................................................................................................................	0	83	165	228
+3542	PF03825	Nuc_H_symport		Nucleoside H+ symporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.27	0.70	-5.71	4	1944	2012-10-03 03:33:39	2003-04-07 12:59:11	11	11	949	0	284	2015	437	383.60	38	93.67	CHANGED	Mshsh+LplM.FLQahIWGuWhssLhsYMhhoh.FsuuplGhVYSuhGIAAllhPhlhG.lAD+ahSAc+shAlsHhlGAlsLahAApsTs.tshFhlhLl.ShsYMPTluLoNSIuausLt....DssssFPsIRlhGTlGaIhu.......hhlluhuslE.oph.LhIuAusShlLusaALTLP+hP.scppAspulsshLGLDAFhLh+s.phhlFFlhohlhus.Lphh.lFuNsFLpshst.......hhsphuollhSluQhuElhFhLslPFFLpRaGIKsVMllulVuaslRFuhFAYG.DssshshsLLlLuhllaGsuaDFF.lou.lFV-pcsssslRuSAQGLFhhhspGhGsllGuhluG.hhlchaohsG.....shDWpTlWLlhAuhulhlAslFhhhF+.scs	..........................................................................................................................MthphpLphh....Flp.ahl.W...Gu...W...h..s...s....L.u.....a...h.h.s......o..h..Fsuup.....IGh.l.Yus.h.uIAA..ll.h.P.h.L...l.G...h...l...u...D...+...a...h..s...Ap...+....l....h....u....l..h....p.....h...s...u.A......l....h..........h.......a.........h.......A................A.......p...........................T......s............s...s...h....F...h...l....h...L..h.........u...h...s...Y...M...P..T....l...u..L...s...N..o..lu.a..s..plt............D.h.s.p.D.FP......I.R..la....G.TI......G.F..I.h..u...........................h........h...h....l...........u...........h..........s....s...h...p.....o...........p...h........L....h..I..s...u...........u....s....S..h..l..L........u..l.......a........s..............h...s.....L.....P......c....h......P.........s........c..p.........p..........u.............p....p.....s....h..p.....s....h........L.G....L.......D..A....h..s......L...h.+...................s...+.p...h.....h.l.F....F.l..h.....u.....h.L..l.u..s...s...L..t.h..h......h...Fu..Ns..a...Lp.s.hu............................h..s.p.p.s...o..h...h..h.......o...l.uQ..h....S....El.h..F.hL...s..l....PF.F....h+....R.a....G..I....K..pV..h.L.l.u...h..lu..h.s.l.Ra.u..hF.u...aG.s..ss..........h......sh.s.L..Ll...L...uh....l.....laGs.u.FD.F.a...lou......laV.-pcs.s.sp.h.Ruu..AQGl.h...h...h...h...sp...GhGshlG.sh....luG....hh.h...c.h.a....s......s.t..........................................hh.s....W.ps.h.W.h.hhA..sh..hl.l.A.hhF..h..hh.F+.pc.h................................................................................................	2	107	174	238
+3543	PF02321	OEP		Outer membrane efflux protein	Bateman A	anon	Bateman A	Family	The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria.\	   Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.	30.90	30.90	30.90	30.90	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.95	0.71	-4.70	113	30969	2012-10-02 20:27:15	2003-04-07 12:59:11	13	38	2653	50	9040	27392	6704	187.10	16	75.76	CHANGED	hpphhptshpp....ssplptt...ptphpts.ptphphtpst.h.hPplshssshshptststtht.................................................hslsl......shslas.....spttsphctuptphptsptphppsppplthpltpsahphht.spppl.phtpptlptscpthphtpppaptGthsh....s.lhpsptp..hhpsctphhpsptphptshtpLtthhu	.........................................................................................................h.t.slpp....p..ss...lp..tA.....ptp..lptA...ptplp..hucu.......s...h..h......P...s...l....s...l.....s..u....s...h......s...h..s...p..s...s..h.s..s..h..h.t.t.t...t.................................................................................................................hu.l..s.l.......................................sh...s.l.h.ph..............Gphps...plc.t.A..ptphp..t..u..pt..p..h...p....p....s....thsl...h..t...pl.s.p...sa.hs.htt...tpppl..p....h.t...p........p.......t.l.p.s.t....p.ps.hc..h..s..p..p......p.a..p......s...G..h..ssh..h..........-..lhpAptp.....hhps.p..tp.h..hpsptphttsthpLtthhG................................................................	0	2657	5583	7554
+3544	PF02265	S1-P1_nuclease	Nuclease; 	S1/P1 Nuclease	Bateman A, Mian N	anon	Pfam-B_2480 (release 5.2)	Domain	This family contains both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity.	21.90	21.90	21.90	22.00	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.12	0.70	-4.75	81	645	2012-10-01 21:01:47	2003-04-07 12:59:11	11	7	360	1	375	699	285	243.10	24	82.02	CHANGED	WGppGHhhlupIApphL.sspstptlpplL.ss............ssLuplusWADcl+p......h.................chsus....WHalsh.s.t..........t...aspsh....t.s.ppss.lluuIpphsstLpctpts..ppp+........spALtaLlHFlGDlHQPLH.suh......ttDpGGNslpVpah......scp.....s........NLHplWDothl..psh.t.............shsphsssL.pphs....tpphpsht........h.s...s....................htWApEShphup..phsh.....ssspssps...Lus..p.YhtsthsllcppltpuGlRLAshLNplhs	............................................................................................................WuttGHhhlutlApph...L...sspstttlp.plLst...............................ssl.sp...husWs.D...pl+t.....t.....h.....................................................ph..sus...hHal.shst.................................................spsh..........tp....s..psts..lhsulp..phtp.tL.t...stpts........ttpp..........................................s.uLta...lsHhlGDlH.......QPLH.s.uh.......................tDtGGNplp.lph...........spp...........s.............................NLHplWDst...hh.....pphht...........................................shpthh..ptl..pphs..............tpphpth....................................s.s....................................tt.asp.-ohp.hsp..p..hsh............................th.tstp.............lst....p.Y..ht..p..ths..lsppplt.uGhRLAthLstlh.t...........................................................................................................	0	171	268	338
+3545	PF03066	Nucleoplasmin		Nucleoplasmin	Griffiths-Jones SR	anon	Pfam-B_2930 (release 6.4)	Family	Nucleoplasmins are also known as chromatin decondensation proteins.  They bind to core histones and transfer DNA to them in a reaction that requires ATP.  This is thought to play a  role in the assembly of regular nucleosomal arrays.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-4.69	23	444	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	114	62	203	360	1	149.80	36	64.51	CHANGED	pspsaLaGCELspccpphoFcs.....t--c....cspHpLsL+olCLGspAK-.EhNlVElpu...hsh-upp.lplslAsLKsSshPhVolsGhElsPPVTFRL+sGSGPValSGpH.lshtpt.t.t................................................---EE-p--E-D-ED----pppE-.sPsKps+	.........................................................................pshhaGCELpucc.shpFcs...........-p-.........cs-....HpL.sL+.p...lsLGssAKD...Eh..p.lV.Espu...hsh..-up...lcVslAoL..Kh..S.s.pP.t......VoLs..s..Fp.l.s.P.PVs....h..+L.+.........sG....S......GP..V..aloGp........H.h..ls..hp.p.-t..p....pc...........................................................................pc--...-tt....---p-..-..-..cp......t.................t...........................................................................	0	29	44	89
+3546	PF03177	Nucleoporin_C	Nucleoporin;	Non-repetitive/WGA-negative nucleoporin C-terminal	Mifsud W	anon	Pfam-B_1212 (release 6.5)	Domain	This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterised by the FG repeat Pfam:PF03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore [2].	25.90	25.90	26.70	25.90	25.50	25.60	hmmbuild  -o /dev/null HMM SEED	587	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.99	0.70	-6.00	63	645	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	273	7	432	629	4	485.40	17	42.05	CHANGED	hsssh.pppLchhhpslpsLhcFlppsts............................................................hstppchtlhtctctlsuhhtLhpphpcthshhp.hlhp.............................p............hsshhhhlsp.sphpplhshtacplht.....sp.p.tp.htp.Llsshlspslhpsu..th-.phusth...p.ps...........ssh.t.........................phhpup.pssh.shcp.hchhlp...............hpth.tph.......shpshpptssphhshphhttshtl.hhphsptt.spsppshphhpc.tt.pps....+p..ht.htp.hshac.shplhcphcshsshsp.h................................t...ppttphppch.phhtphs-.sFthtlYcahlpp...sth.phh.phppsalhpaLpc..................................thucLhWlahhppp.cahpAApsLhpL....sps..................hpcRl-hhhptluthsst.......s.................htphlpclpchl-lsplQcplhp.hlps.tph.....................ttp..h....pthhpt.....................Lhsphshshphh.................................lpLthhphss......stthlptlWpchltp..s...p....pttttt..........................hpthphthsslhpplpts.hshshsthh.h	................................................................................t......pplp.h.pthptLhpFlpp.t.h...........................................................................thttphth.tctptlt.....uhhtLh...ph.t...ph.th..ht..hh.p................................................................................t.............hp.h.hhhtp.pt.pplh...thhhc.p.....lh................p...hp.....hth.l...hs.l..hthhpsu.............hc.thsphh....p.tp..............................s.h.p.....................................hpup.ph....t.h.p.....hc.hhp.....................................ht.....h..................................htth......s.tph.hp..hp.h...t.hhh.h......hh........hst.t.....p....t.t.s.p.......pp...t.....tp........p..........pt.....h.p.httap.hhp...hh...p.ph....shs.ths..h......................................ttsp.hpph.ph...hpp.t-....Fp..hlapWh.l.....pp...........shh..ph.....h..p............p.pshltpaLpp...........................................h.cLh..Wha.hppp..pat.pAA.psLhpL.u...spp.....................................hpc+hthhhtt.lsthsstt.......................................tphlcclppphc.lhplQpplhp..hlpt.ttt...........................................................th.t...................httLhsphs.shp..h....................................................hph.h.p.tt.t...........p.thhpthWpphlpp...p..........ptt.................................h...thh.lhphh..........................................................................................	0	144	236	357
+3548	PF01773	Nucleos_tra2_N	Nucleoside_tra2; 	Na+ dependent nucleoside transporter N-terminus	Bashton M, Bateman A, Yeats C	anon	Yeats C	Family	This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the N terminus of this family	21.50	21.50	22.10	22.10	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.15	0.72	-3.64	166	4054	2009-09-11 09:51:31	2003-04-07 12:59:11	15	8	1905	1	661	2186	512	74.60	34	17.73	CHANGED	lGlllllhlAaLhSpsR+.sIphRsVh...hulslQllluhhlLpsshGpshlpslusslspllsauptGssFl..FGsLs	.......lGllVllslAaLhSs....sRK..pIphRs..Vh...hhLllQlhluhhhLt..........ss..hG..t.thlpshup...shppllsaus.s.GssFlFGul...........	0	162	320	492
+3549	PF03800	Nuf2		Nuf2 family	Bateman A	anon	[1]	Family	Members of this family are components of the mitotic spindle.  It has been shown that Nuf2 from yeast is part of a complex called the Ndc80p complex [1]. This complex is thought to bind to the microtubules of the spindle. An arabidopsis protein has been included in this family that has previously not been identified as a member of this family, Swiss:Q9C953. The match is not strong, but in common with other members of this family contains coiled-coil to the C terminus of this region.	20.90	20.90	21.50	21.50	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.68	0.71	-4.23	31	294	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	249	4	211	290	3	143.80	25	32.91	CHANGED	hsp......t.sFPhLsscEIlssLps...hsls.hotcsLp+......PssphlpplYpphlphhhGh.sh-pl.t..........hhtsstpslp.sp.................hhp-slshhshh+hhpchh.ssGls.DFshpDlh+PcscRhp+hLSullNas+FREp+h...thhcctlpchcsth	.................................................................................hp......p.sa.h.LsspEIstplpp............h..sl...s....hstpslt+.............Pp..s..ph..lphlap.thlphhhsh..sh.-sh.......................hhhsstpslp..sp......................................hhpss.hsl..hshatph.pchh.ts.....sls......DFshsDlhcP..p..s..cRht+...hLSull....NFh+FREpph...thhpchhtphcp.t........................	0	69	116	172
+3551	PF04121	Nup84_Nup100		Nuclear pore protein 84 / 107 	Wood V, Finn RD	anon	Pfam-B_13117 (release 7.3);	Family	Nup84p forms a complex with five proteins, of which Nup120p,  Nup85p, Sec13p, and a Sec13p homologues. This Nup84p complex in  conjunction with Sec13-type proteins is required for correct  nuclear pore biogenesis [1].	18.50	18.50	18.60	18.60	18.00	18.40	hmmbuild  -o /dev/null HMM SEED	697	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.03	0.70	-6.85	16	402	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	252	7	259	410	4	519.90	20	76.82	CHANGED	pphp.hcLEtchW+LlptLaphR...htpppccptphc.........shsSctsh.cplhppNsplhEhpLllsWLcssh.t..h-tssslsh...os+WpNTlhslt.pht..shs.tt......shVpslDsDAPlR-pps.LcstDcpcDppla+hlFpLlhsGpl-EAhchCcpoGNhhhuhILpG...hcpa.hDPslDhphss.........................ps.pGsp++sLW++ssaplupssplDcYERAIYuhLu.Gslss.lslsts.sWEchLhsYlsphhshplEs.lhspshssp........h.lPpphht....olpplhspL.stpssclh-puccPlRll.stlILsslssllcshschL.sshss.....t..tpsalLRllTHLslFl+hlsh.tp.p.sDc..llssYlphLtttt.h-LIPhYloaL.spp.tl-tYShFLpsls-sptRc+QlElupphuLs....................lssIh+pTVppl.hp-o-pthh.sspssh.....p.clochDp+lIsulEWL.h-sp.hs-ulppuhAlhR+FLhsGKlcuh+phhpthshcslhp.Yph....t..cslssc--......sshcEllpYcshlpulctap-Wpch..........................pppp.sscpphsphpp+lpthopsshcLlhshLlt................s-sp....pctphh.plRsLYlPhllhtLHp..lhtpsp.....hhpculpLushVAsEscplYh.lF.ssG+LpEaLpplucsShl	....................................................................t.....hp.Eh.hWpLl..lh............c.................t......................................ott..h.pt..h...h.t.tst.hh.p...h.lhpWLpt.h.............................t.......................................thhW..........Th.tl...............................................hlpplDsDAshR..pt.....h..........Lp..Dp..-.thhhhhaphlRtG...h.p.c.h.chspptsp.W+Ah.lt...G............h...........ss.t.p...t...........................................................s.........p.tlW+hssh..........t....h.up..........p............t.........t...........h.......s......a..................-+Alau..hls...G.pht..t......h.....h...ls..p.....sWc-hlashhp.h.l.p..hc....t.l.t.............................................h.st.....h...........................s..h.....p...p.hh.pt..l.......t.t..p.th.t..tspp..h.phlpt........llh..t...........ph..s.t.......h.h..p...th.........l...t.........t............................................................................................................................................................................h................lRhhsHl....h..lhhp...l.t...............................................t...............p......................................t.........................l...l.......t..tYl.p.h.L........t......t.....p..hlshYss.L.st..th.......t.hu.hL.t.l..........p....p.......+............l...phh.....h...tls.............................................h..thhp.......h....p.....h....htt................................................................hp.....-...h....hpsl-Wh...h.s............t.h.c...........hh..s.hhh+ha.h......h.........tp.h...tshp.hh..h........t...h.................................................................................p........h....t.h.....p....hhth..p.h..ph.p.............................................................t.......t..t......h.......h.....hp.......t.....h..h...h.........thl..................................................................................................h..lRthhhP.hh.h.h.t........h..tt.....................................h.........tshths..lu..p...hh.................h........tt..t..p...h..hh..h............................................................................................................................................................................................................................................	1	84	143	213
+3552	PF01029	NusB		NusB family	Finn RD, Bateman A	anon	Bateman A	Domain	The NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination. 	21.30	21.30	21.40	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.47	0.71	-4.18	114	7994	2009-09-17 00:13:35	2003-04-07 12:59:11	13	8	4433	32	1709	5198	2636	125.80	25	44.18	CHANGED	pp...s....RphAhpsLhph............................htpthhpthhs...............hspp.spsahppLlhGshcphtplDthlsp.hh.shslc+hshhs+slLRlulaElha..h..clPspsslsEuV-luKph...ssppsst..FlNuVLcplt+	....................................................................................................................psRphAhpsLhph.............................ptthhs.hhs.........................ttt.h.sst....Dtsh.hp..cLl...hGshpppspL.Dthlst..hh....s..hs.l..pc..l.s..t.h..+.sl.LRluhYplha.........h.....clP......s..+....s....sl.sEuVElAKph..........uspp....s.tp...alNGVLcphh.............................	1	580	1130	1455
+3553	PF02357	NusG		Transcription termination factor nusG	Bashton M, Bateman A, Finn RD	anon	Pfam-B_697 (release 5.2)	Family	\N	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.45	0.72	-3.75	170	5994	2012-10-02 20:41:53	2003-04-07 12:59:11	14	4	4395	19	1234	3385	2659	97.80	33	51.97	CHANGED	tpWYllpstsspEp...c..ltp...pL.p....p..t..lps..................hlPhtph....ch...ps........+hp...ppshaPGYlFlchshs....s......p.....h..htl........pss..uVss...hl.......G.......sp.....Pss.......lscp	.................................................................pWYllp..sa..S.GhEp....+..Vpp................sL...c.........p....p....lps.shtc...............................hhplhlPpEcl.....hcl+...sG........+pp..hc+phFPGYVLVchshs.............D..........c..........s..Wpl......l+sT....PsV.s.G..Fl.........u...........s+......PsPl.p.t...........................................	0	418	810	1052
+3554	PF04277	OAD_gamma		Oxaloacetate decarboxylase, gamma chain 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	21.20	21.20	21.20	21.20	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.65	0.72	-3.61	96	1171	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	853	0	225	777	96	73.50	28	65.31	CHANGED	ltpultlM.lhGMuhVFlFLhlLlhhlplhupl....hpch.............ssppssssstss.sspststt................s............sscllAsIsAAlppa+pp	..............puhtlh.hlGMuhVFhh...Lh...lLlhslphhutl...........lsch........................hsc.s..s...s.s.tsts..tssss.................................................s...................................sclhAsIs.AAlppap..t.....................	0	83	144	191
+3555	PF03977	OAD_beta	OadB_MmdB;	Na+-transporting oxaloacetate decarboxylase beta subunit	Bateman A	anon	COG1883	Family	Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis [2].	30.00	30.00	30.40	30.50	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.12	0.70	-5.71	9	1424	2012-10-02 17:06:44	2003-04-07 12:59:11	8	5	969	0	273	1037	261	354.20	54	94.72	CHANGED	plG....................pllMllVGlhLlYLuItKcaEPLLLlPIGFGslLsNlPtuGls..shp......................................................GhhhhhaphuIsstlhPLLIFhGlGAhTDFGPLlANPKTlLLGAAAQhGIFhslhsAlhL....G..Folt-AASIGIIGGADGPTuIYloopLAP-LLusIAVAAYSYMALVPIIQPPlh+hLTTpcERKI+Mp.QLRpVS+hEKIlFPIllhllsuLLlPsAsPLlGMlhhGNLhREsGVV-RLucsAQptLlNIVTIhLGLuVGSphpADpFLsspTLhIlsLGllAFssuTAGGVlhAKlMNhFppcKINPhIGAAGVSAVPMuARVspKluhEEDPpNFlLMHAMGPNVAGVIGSAlAAGVhLthlu	........................................s..GphlMllluhlLlaLAItKpaEPLLLlPIGFGslLsN.....l.P..........u.....Ghh...................................................................................................................................................................................................sGhLhhhaphuIp.o.ulhPhlIFhGlGAMTDFGPLlANP+s.lL.LGAA.AQFGIFsollsAlhL...............u......F.oht.pAAuIGIIGGADGPTuIaluu+L....A............P.c...L.LGuIAVAAYSYMALVPlIQPPIMKhLTTccERpI+M..t....ph.....R..p.......V..S.........KpE.......KIlFPlllhllsuLllPsusPLlGMhhhGNLhREuG.V.l-.RLScTAQNtLlNIVTIhLGLoVGuphpA-pFLp.pTLtIlsLGllAFshuTAuGVLhAKlhNh....h.o..+....p....KINPLIGuAGVSAVPMAARVspKlGh-tsPpNFLLMHAMGPNVAGVIGSAlAAGlhLshl.h.................................................	0	113	184	234
+3556	PF04225	OapA		Opacity-associated protein A LysM-like domain	Mifsud W, Bateman A	anon	COG3061	Domain	This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1,2]. This is a LysM-like domain.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.78	0.72	-4.09	12	1645	2012-10-01 23:00:54	2003-04-07 12:59:11	7	7	935	1	206	836	122	83.80	37	23.87	CHANGED	sW+papVtpGsTLhQlFRcNsLsloDlsAhs+lEGusKPLSplKsGQhl+hplsspGplstLplEsssp.tlhFhRtuDGoatRsK	........+pYhVpsG-TLuplF.ppa.GlshsDlhtlAps.p..s....s.K.sLsN.L+sGQplph.ph.s.A.s.G.p..L.ptL.o..h-.s.upppph.h.asRp.ss.G.ua....h....................	0	28	71	142
+3558	PF03373	Octapeptide		Octapeptide repeat	Bateman A	anon	Bateman A	Repeat	This octapeptide repeat is found in several bacterial proteins. The function of this repeat is unknown.	17.50	3.90	17.90	3.90	17.10	3.80	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.78	-5.53	0.78	-5.51	0.78	-2.61	3	3282	2009-01-15 18:05:59	2003-04-07 12:59:11	9	83	143	0	12	2907	0	8.00	83	23.91	CHANGED	PGKEDNNK	PGKEDsNK..	0	12	12	12
+3559	PF02317	Octopine_DH		NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_9653 (release 5.2)	Family	This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	23.30	23.30	23.50	24.20	22.80	23.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.55	47	615	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	543	5	140	433	40	146.60	33	43.51	CHANGED	lphtpshLphsLsNhsslhHPshhlhshuphc......................thp.......sch.hahpGhs...stsucllcslDpERhslApAluhph..hshtphhph..tY.......thcsss..lhchhpssp.uasslssPss.hp..........pRYlhEDlPhGLlshtuluchhGVssPhhcullphssshhGc	......................................h.shtpsllpssLpNsNs.lHPs.hlhNhGpl-.......................as............uEaslat-Glo...cpssclLcul-tERlsluctL.Ghch.........shp-s..hh......ptYh.......................tttp.-s.ps..L...pch..hpTss.sastl..s.sPsp.hc.....................sRYlsEDlsaGLshhsuluchhs.VsTPsh-ullhlusshht.p.........	0	53	95	127
+3561	PF02101	Ocular_alb		Ocular albinism type 1 protein	Mian N, Bateman A	anon	IPR001414	Family	\N	25.00	25.00	32.20	31.50	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	405	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.42	0.70	-5.87	2	77	2012-10-03 04:04:29	2003-04-07 12:59:11	10	2	52	0	48	82	0	326.40	45	95.20	CHANGED	MASPRLGhFCCPThDAATQLVLSFQPRsFHALCLGSGsLRLsLGLLQLLsGRRssG.tuPATSPsASV+ILRAAsACDLLGCLGhVIRSTVWluaPpFl-slSshNtT-IWPAsFCVGSAMWIQLLYSACFWWLFCYAVDsYLVIRRSAGhSTILLYHIMAWGLAsLLCVEGAsMLYYPSVSRCERGLDHAIPHYVThYLPLLLVLVANPILFpKTVTuVASLLKGRpGlYTENERhMGAVIKhRFFKIMLVLIhCWLSNIINESLLFYLEMQsDIpGGSLK.lpsAA+TTWFIMGILNPAQGhLLSLAFYGWTGCSLshpsP+h.IQWEohTsSAAEGsa.oPl...hPHpNPt..KVspVGGpTSDEsLShLSEsSDASTlEIHTAotSCNhpEsDsh..spG-L	.................................................MAsPpl..hCC.....h...s.s.t..hh.tFp..hatshslsSushthhhslhQlh.............h..t...........t....................................t...p...IlhhhshsDhLushGllhRSsl..Wlu.h.Pshlp.shSshst.o.claP........ss.F...CV.u.S.u...hWIQ.L.hYSAsFW.WhFCY.AVDsa.LVl..+c.SAG.hSs.ll.LYHhhsWGLAsLLslEGhshLYa...P.....S.....h..u.....p.C...E.pGLp......HA....I....PHYlTTYhPLLLVLluNPILFp+TlsuVsSLLKGR.pGIYTENERRhus.IKlRFFKIMLVFhlC..WlsNIINEoLL.FYL......EhQsDl........psssL+.l...+.s..AAhhTWaIMGILNPhQGFL.oLAFaGWT.Ghp.lth.....p.h.h.W-phssS.h.s.tt......................p...t.........p.....tpp.s-slshLSE................................................................................................	0	14	18	32
+3562	PF02100	ODC_AZ		Ornithine decarboxylase antizyme	Mian N, Bateman A, Moxon SJ, Wood V	anon	IPR002993 & Pfam-B_34796 (release 7.7)	Family	This family consists of ornithine decarboxylase antizyme proteins. The polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is degraded by the 26 S proteasome via a ubiquitin-independent pathway. Its degradation is greatly accelerated by association with the polyamine-induced regulatory protein antizyme 1 (AZ1) [1].	23.90	23.90	24.00	25.70	23.40	23.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.58	0.72	-4.57	28	301	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	183	1	182	274	0	105.80	32	48.95	CHANGED	hsssphspW......pslls....................ppsL..aV.lPp.sshspu.........................................KculhuLLEaA--p.LpssclhlshpKscs-...pssLlRohpalGFcllsss.p.............ss.......sschhaMsasl	..............................................................................s......pW.......tlhs.........................spsL...alp.lPt..ssLspG........................................sK-ulhuLLEaAEEp.Lp.....sspVhlChc+sRsD.....RusLl+sFs.alGFEllpPs.c............................................shsP........pschhFMsY.h..........................	0	47	74	125
+3563	PF02423	OCD_Mu_crystall	ODC_Mu_crystall; 	Ornithine cyclodeaminase/mu-crystallin family	Bateman A	anon	Pfam-B_1960 (release 5.4)	Family	This family contains the bacterial Ornithine cyclodeaminase enzyme EC:4.3.1.12, which catalyses the deamination of ornithine to proline [1]. This family also contains mu-Crystallin the major component of the eye lens in several Australian marsupials, mRNA for this protein has also been found in human retina [2].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.69	0.70	-5.66	11	2697	2012-10-10 17:06:42	2003-04-07 12:59:11	10	13	1722	12	903	3070	1011	299.80	23	91.90	CHANGED	scshhhhttcVthcshhs.chhshlEssFRpaups...thcpsP+lssas+c....GslclMPsh.us...hhGhKaVsuaPcNscp.GLPTlsAhhVLs-ssoG.hPlhLh-sshLTAlRTAAsuAluuKaLA.psupshAlIGsGsQuhhQscAhptlhs.lpcl+laDlcscusc+hupplpt...thplsAssssppAVcGADllsTsTsscp......sllpssaVpsGsHlNAlGuDssGKsELcs-lLtcADlaV.-a.sQs+tpGElpp.................lssccshspLu-VhsGphsGRsssccITlFDSsGhAlcDhushchla-pspsts	.......................................................................................h......................thhph...lpp.s.h.t.ths...pt........th...ts......sp......h.......h..h.........h.....p............ts..hh.h...h.MPu........h....h..........s.......s.........................h...............hGh.K.......hl.s......s...........h..s......p.....Ns....p..........p....u....h........s.........s..h.........p....u..h.h.l..L..hD.s..pT.G.hs.h.u.l.h.-ushlTshRT.A..A...s..o....u.l..A.......s....c..h....L.........A.....p....p.......s.....u.........c.........s........l........s.....llG.s.GhQA.p.h.p.l.p....u..h...t....t......l.......h.......s....l..cc...l.....t......l......a.............s........p...s..............p....p..s............p....p....h.............s........p............p....h.........p...........t.........h..........t..............h...........p.......h......h.............s.........s..........p.............s........s.........p.........c.............A.........l...........p....s....A.......D......l.......l.s....o.sTsupp...............P..l..l..p..s..........p.....h...l.............p.....s....G........s............a....l....s...s..l.G.u....p.s...s.h..p.E.l...s........s....c..l....l.....t.....p.......u..........p............l....hV....-.....h.......s.......t...h.....p.......c.....t.G.-.lh........................................................hs.t..p....t...h....h..s..-....L..u......p.l.........l........s.....G....p.....t......s.....s...........R........p.....s.........s.......c..........c.............l........o..l...........F.cssGhulpDlssAph.lhpph....s..................................................................................................................................................................................	0	225	509	735
+3564	PF02159	Oest_recep		Oestrogen receptor	Mian N, Bateman A	anon	IPR001292	Family	\N	20.60	20.60	21.80	21.20	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.98	0.71	-4.05	11	220	2009-09-12 00:57:07	2003-04-07 12:59:11	10	10	133	0	28	206	0	120.80	46	25.14	CHANGED	MYs-ps+s.....ushNY.-GA.YD.....Fssss....suAPs.apsuolu....Yhsus..ssaGssu.uthpoLsssssSPLhFlp.ouPQLSPaL.H.sG.....pQVsYYL..........-ousoshYRSSsssppQuu....cEhhouus-............+Guhuh-SsKE	....................hYs-ps+s......ushsY.EGs.Y-.....assss......ssuPl.Yuposls....Yhsus...suaGssu.Guh.sLs.osssSPLhhl..ssP....Q.LSPFl.H.tu.....pQVsYYL...........EsussshYRsssssppQuu....cEp.huoos-..............+GuhuhESsKE...................	1	2	4	11
+3565	PF04664	OGFr_N		Opioid growth factor receptor (OGFr) conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4529 (release 7.5)	Family	Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus [1].	19.80	19.80	19.80	21.00	18.70	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.26	0.70	-5.01	13	234	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	123	0	109	217	96	177.60	34	53.33	CHANGED	hh-.c.s.-h..........hNL+FYpNEIshp...PsGhaI--lLppWpss.....Y-hLEcNHoYIQWLFPlcEpG.lNhpApsLThcEIctF+psc-l+++hlcuYclMLcFaGIcLs-c+sGpVpRApNappRFpNLNcasHNpLRITRILKsLGpL.GhEpapsPLV+FFL...pEoLVptpLssl+pSuLD.YFhFsl+s+ppRRELltaAataacPptcFlWGP.chhphp	..............................................ht.....................lpFYpsch.........spGhhI-plhppW.ts...........YchLEcsHsYIQWL.FPlpE.u..hN..hh...A..LTtpElc...tF+psp...ch....hc+hlp.uYch.MLpFaGlcLt.............s.p.sG...p.....l...t...+.u...t..s.............a...p...........cR.a.p.p.....L..s.pp.pHN.............LRITRILKSLupL.GhcpapssLs+ahl...pctlhppph..s..s.lp.puslc.Yah.slh.................................p................................................................	0	34	49	73
+3566	PF04680	OGFr_III	OGFr_repeat; 	Opioid growth factor receptor repeat	Waterfield DI, Finn RD	anon	Pfam-B_4529 (release 7.5)	Repeat	Proline-rich repeat found only in a human opioid growth factor receptor [1]. 	19.50	19.50	20.90	19.50	17.20	19.30	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.41	0.73	-6.43	0.73	-3.63	4	97	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	10	0	7	144	0	21.10	66	13.11	CHANGED	uPpET.GPRsAs....Pss...DpPAE	.uPpETPGPpsAG....PAu...DpPAE.....	0	7	7	7
+3567	PF04606	Ogr_Delta		Ogr/Delta-like zinc finger	Mifsud W	anon	Pfam-B_5059 (release 7.5)	Family	This is a viral family of phage zinc-binding transcriptional activators, which also contains cryptic members in some bacterial genomes [1]. The P4 phage delta protein contains two such domains attached covalently, while the P2 phage Ogr proteins possess one domain but function as dimers. All the members of this family have the following consensus sequence: C-X(2)-C-X(3)-A-(X)2-R-X(15)-C-X(4)-C-X(3)-F [2]. This family also includes zinc fingers in recombinase proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.63	0.72	-4.30	67	983	2012-10-03 10:42:43	2003-04-07 12:59:11	7	4	577	0	122	677	13	46.70	40	45.45	CHANGED	pCPpCsspA+hRoocth..otps.....pc....hYtpCpNh.p.....CupoFsst.ohs+sl	...........pCPhCss.s.A..+sR..o.Sp..h.....osps.....+-.....+YhQCpNl.p......CutTFhohEohp+hl....................	0	13	47	82
+3568	PF01276	OKR_DC_1		Orn/Lys/Arg decarboxylase, major domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.29	0.70	-5.93	10	4944	2012-10-02 18:26:03	2003-04-07 12:59:11	15	15	2315	25	649	3284	459	379.60	33	61.32	CHANGED	PPFaKALhcYVccsphoFssPGHpGGssFpKcPAGphFYDFaGENlF+uDlssusspLGDLLtHpGstp-ApcaAA+VFsAD+oYFVlNGTSsuNKlVs.AlsssGDhVLlDRNsHKSlpH.ALhhuGAsPVYLcPs.RNsaGllGGIstppFpc-sl+ctls-ssss+s......hhAVIpNuTYDGslYNs+pll-plc+hss.IhFDSAWVuYppFt.Phhtssoshtu-..p.ps.sIhsTQSsHKhhAuFSQuShIHhK-sph......ls+cRFNpAaMMHsSTSPaYPlhASLDVAAuMhcGsuG++Lhp-slcpulchRKpl........lssuphFcPatPplVcspp....................ha.hcssppWHuFcshsspphalDPsKlhLpTPGhs.csG-hc-hGlPAslVApaLcEp.GIlsEKoD..sILFLho.GtscsK	.............................................................sPhhcALh.p.Yscp.t.phsF...s.s.PGH.....ps.Gp.h.a.p+......pP.sGp......ah-a...aG....c..shh+s.Dls...shst.L.......GsLLpH.pGs.h.t-A.pchsA+...sF.sA....-....+o.........ah..VlNGT.SsuN+slh..us......h......s........s.G........-........h.l.L.lDRNsHKS.lhp...uLh..hs....G..u.p.P.l.Y.l.css..R..........Nt.h.G.l.l....G.G..Is..t.p..php............p..hl..p...ct....l.p..c.....s.....s.s.s..ps.....................hsl.ls.p..s.TY..D..Ghh..Y...N...sc..t....lh...c...h....l...p...p..h..s.........l..hF..DpAWsuat..p.Fp....s....h.....ht.s.p..........s..htu-.........t..t.....hl.hsTQSsHKhhuuhS.QuShIHl+ss.....................hsc.cph....N..p.A.ahhHsoTS...PtYslhASl....D.su.sphhcut..sG...........c.pLh.pc.slchu.............lc.hR+tl................sps..hhh...cs..a............lss...........................h.a..h.....s.s.....t...tWH.u.F..t.s..h......t.t.......hlDPhKlhlhs......PGht...pG.ph.p.p.....GlPAs.ll..s.t.aL.t.c.p.Gllsp+ss..slhhLho.u.s.t............................................................................................................................................................................	1	197	374	507
+3569	PF03711	OKR_DC_1_C		Orn/Lys/Arg decarboxylase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.20	20.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.69	0.71	-4.12	32	4706	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	2279	25	600	2682	216	119.40	31	18.69	CHANGED	LPslapppPchYcshsl+-LCQphHcha+ppslhpLppchF..sshPchsMsPpcAatchl+sclEhVslc-h.GRluAphhLPYPPGlslllPGEha...upsllcYhhhLp-hhspaPGFps-IpGlahppcsst	.............................................................hPplhtt.......Yt.th.tlppL.spthath..hh..p....s.......t..h...........th...a..........p.h.hP..p...h.hh....s....P..pp.A..a.....t..l...c.s....p....sEhV..slc..c....h..GR.......l.......u.......AphllPYPPGlPllhPGEhh........s.ps.ll.cYlt.h.Lp.p...h..thhP.G.Ft..-hpGh.......s..........................	0	176	343	466
+3570	PF03709	OKR_DC_1_N		Orn/Lys/Arg decarboxylase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This domain has a flavodoxin-like fold, and is termed the "wing" domain because of its position in the overall 3D  structure.	28.60	28.60	28.60	29.00	28.40	28.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.18	0.71	-4.03	82	2923	2012-10-01 22:20:39	2003-04-07 12:59:11	10	5	1008	23	274	1331	55	108.10	28	15.04	CHANGED	hpttshppltptlpt.pshplltssshcch..hh..tscluulllsh-................phtpsllpplcppshplPlFlhsct...sspplsschlppls...thhph.hpssscahApplppAsppY	........................hpttslccLtssLst.pshpllhssspc-h..hhp.psclsul..lhshs........................c.stsllsclcpp.s.pl...PlFhhssp....sshcl.s.s.shhphl.....tahph...h.sss-.lAtclcpssscY................................	0	34	100	179
+3571	PF01277	Oleosin		Oleosin	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	20.70	22.80	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.49	0.71	-4.53	15	355	2012-10-03 03:08:05	2003-04-07 12:59:11	12	4	58	0	111	359	0	107.80	35	54.63	CHANGED	SosQlLsllsulPlGGsLLsLAGLTLAGTlIGLsVATPLFVIFSPVLVPAslsIGLAlTGFLsSGuFGlTuLSSlSWlhsYlRtppssss-pl-hAKtphp-hstasGpKs+-hGp+h	...................pllpslsusssussLLlLuGLTLs.GolluLsluTPLhlIFS.PlLVP..AsIsssLlssGFluuGuhGlsAl.uslsWlh+ahpu.....t.p..s......h....s....th..p.hh...........................t.......................................	0	25	71	86
+3572	PF02191	OLF		Olfactomedin-like domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.80	20.80	21.20	21.20	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.73	0.70	-5.11	40	1087	2009-01-15 18:05:59	2003-04-07 12:59:11	11	39	91	0	497	860	0	245.70	37	33.48	CHANGED	sLhslupPhhl.....+pssp...phGuWh+Dsh.....tssc+lahhsshsss...p..lhcapphpsF........htsptspp.........hpLP......hshpGsGaVV.Ys.GulYYpct............popsllKa-Lsspslsspp.LssA.uap..s.hsYthuuhosIDlAVDEpGLWlIYuTppssGp.....IVlS+LsPpoLpl..ppoWsTsh.KpssuNAFhlCGsLYsscohstps..........scIpYsaDTp..ssppp.tsslsFpppapthstlcYNP+-ppLYsWssGa.lhYslphtp	................................................................................h.LpslspPhpl.....ppssp...phGuWh+DPh......pssc+l..a...hh.sh.h.tp....pplhEY.pshpsF............htuptsps............................a+LP.......athpGTGaVV.Ys.GulaaN+t..............popsIlKaDLco........ch.........hs.s...............pt...............hlssA..sYc....................s..p.P...Y....p..W....u...GpoDIDLAVD.Es.GLWlIYuTpp..s..s...Gp.......IVlSpL....sP.hTLpl..cpTWc.T.s.h.sK.puAuN.AFhlCGlLYslcSh.psp..........sclpYsYsTp......ps.pt.p.h......ss.ls.F.......NpYp.aluhlDYNP.+DptLYsWsN..sa.ltYslph...................................	0	66	116	258
+3573	PF00691	OmpA		OmpA family	Bateman A	anon	Pfam-B_166 (release 2.1)	Family	The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.65	0.72	-3.58	84	17270	2009-09-13 10:58:36	2003-04-07 12:59:11	15	239	3418	100	4376	13311	4143	97.50	27	31.23	CHANGED	hFs.sssp.l..s.......spspptLp....plu..phlp...........t........ltltGa.....................sss........hss....tpt....NhpLStpRApsVtph.Lhp.tG....ls.sp...cl...h..puhGp..spshssssssp.spthp.........R	..........................................................hFshspup..l......p........sp..s.p...p...h...Ls..........plA.....phLp.........................p.....h.....lpl.p.GH.....................................................................................TDs............................pGs......pph.........................NhpLSpcRA....pu....Vtph...Lhs...tG...................ls..ss............+l......ps.....hGhGc.......ppPl..ss.s.s..s..tt..spt.N....................................................	0	1365	2716	3618
+3574	PF01389	OmpA_membrane		OmpA-like transmembrane domain	Bateman A	anon	Bateman A	Domain	The structure of OmpA transmembrane domain shows that it consists of an eight stranded beta barrel [1]. This family includes some other distantly related outer membrane proteins with low scores.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.28	0.71	-4.77	13	1301	2012-10-03 17:14:37	2003-04-07 12:59:11	12	16	841	9	132	2219	115	165.60	47	47.12	CHANGED	Pp-NTaYsGuKsGWupaHDss.................psstssHcNshshGsFGGYQlNs.....LuhELGYDahGRhsh+upst..........................sstapsQGspLosKhuYPlsDsLDlYu+lGuhlsRuDsK....tpu.t.......tpsHDstsSsLhAsGlEYAlsPElAsRLEYQalsslGchpstsp............pPs.uslolGlSYRFGQus	..............................................................................................................................................................................................PpsNTaYs..Gu...Kh..G..W.u..p..a...c...Dss....................................sst.ss.c.c..s...p..l..u..h.G........s..F...u.....G......Y..Qh..N.sa...................luh..E...h.......G.....Y....D........a......L.....G..Rh..s...h....c.u...p..........................................................ss.s.a..c..A..p...G.....l.....p.....L......s.....s....K..h..u.........Y......P..........l......s...-....c.....L...Dl..Y..s.....R..L..G...G..h..l....W....R......u.....D...s...+...s.t..............t.........................hpsHD.T..GVS..Pl...h.A....uG..lEY..A..l..T.....s..-lAs..R..L....E...Y.Q....W..s......N....N...I...G...D.sp.o.h.Gs............................RP..D...s..uh....lS....lGlSYRFGQs...................................................................	0	12	44	91
+3575	PF03938	OmpH		Outer membrane protein (OmpH-like)	Bateman A	anon	COG2825	Domain	This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterised as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery [2].	29.20	29.20	29.20	29.20	29.10	29.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.14	0.71	-4.29	151	2754	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2008	6	700	2002	1837	154.60	21	89.11	CHANGED	lslhh.h....hss....................ssst...Ap......................+luhlDhpplhpp..sttcp....hppplppp....hp...phpsc..............................................................................lpphppcl...ppthpphppp..tt.........thsppttppt..pp..chp.....................pptpchpphppphp...pc...........................lpppppp........hhptlhpc.l...ppslpplucp....pshsllls............pss...............llas..ss..sh..DlTscVlptls	...................................................................................................................hh..hhh..h.hss.............sstt.......Ap.........................................Kluhlshpplhp.p..h.st...tps....spppLcpc...........hp...thts-...................................................................................................................................................lpph.ppcl...........psthpchppp....t...........................hhstsptpch....pp.......-lt................................ptppph..ppt.....tpthp........pc...................................htpcppc........thpplhsc..l...ppulcplApp....pshsllls...........tss.......................lhYs..ss....sh...DITscVlcpl......................................................................................................	0	256	489	615
+3576	PF01278	Omptin		Omptin family	Finn RD, Bateman A	anon	Prosite	Family	The omptin family is a family of  serine proteases.	20.10	20.10	20.40	20.40	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.87	0.70	-5.32	7	512	2012-10-03 17:14:37	2003-04-07 12:59:11	15	3	418	9	44	269	1	275.50	56	92.86	CHANGED	uos...s.hsP-shosshSlGsLuGKo+EhVYcs.-sGRKlSQLDWKhpNsAIl+GslsW-.hshlolsApGWToLuStuGpMsDhDWhsS....spss.WTDcSpHPsTplNYANEaDLNlKGWhLpsssY+lGlhAGYQEoRaSaTApGGSYlYsssu....phGsFPssh+sIGYpQ+FphPYIGLsGsYRhscFEhsuhFKaSsWVpApDNDEHY..hRclTFR-KspsppYYusulsAGYYlTssAKlasEhoas+hpptKGsTplhDp.SssoushsssuAGIpNhNahsTAGLpYpF	................................t...h.shoP-slssslSlGsLsGKo+EhVY.s.-s...GRK.lSQLDWKhpNs.AIl..+Gsls.W....-h.......h.s.....l..olsA.tGWTo.L.u.S..t....uGpMVDpDWMsS.......spPG....WTDcSpHPD.Tp..lNYANE...aDLNlKG.....WLL.......ppsNY..+..lGlhA....GYQEoRaSaTA+GG..........S...YI.......Y..........ss...tc.....................IGs..FP...s...G....R....uIGYpQRFcMPYIGLs.G...sY.R.h.p.D.F.EhsuhFKYSsW..Vp.ApDN...DEHY.................h+.+......l..TaRpK.s.cs.ppY.YusulsAGYYlTsNAKlasEhuas+hs.ptKGsTplhD+.sss..Tu.autsuAGIpN.NahsTAGLpYpF.............................................................................	0	10	21	29
+3577	PF03922	OmpW		OmpW family	Bateman A	anon	COG3047	Family	This family includes outer membrane protein W (OmpW) proteins from a variety of bacterial species. This protein may form the receptor for S4 colicins in E. coli [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.23	0.71	-4.64	9	1853	2012-10-03 17:14:37	2003-04-07 12:59:11	9	3	1309	10	354	1343	105	183.40	37	85.72	CHANGED	psGsahl+uthspVhsssusshh.......hsssschs...sssssp.sLohTYhhoDplusEL.............luuT.hpHplssps...sssshluc...sphLPPTLhsQYa..hsssush+PYlGAGlNYshFaspphsss....thoclKLcsuaGhAhplGlDhhls.cshhlNhsVhhhhlcosAshp....sussthcscV+LDPWVhhhGlGa+F	...............................................................................................tGphhhRst.hsVhPspsussh................ssh.sshs........lsss.spluLohoYhhTD.N.lulEL............................................luu...o..PhpHcls..s.s..................s.....h.G..c....lus..........s+.pLPPT..Lhh.Q.Ya..hhsss..u...chRPYV..G..s..Gl...NY.Th.......F.as.p...p.hsss................................uh.o.sl...p...l..c...s.S.aG.s.A.s..p..l..G..hDYhls...cpWhlshsVhYh..sI.cTsushp.............hu..s...s......p......t............p.s...s..l+..l..DPa.V.hhhusGYRF.................................................	0	69	155	256
+3578	PF03532	OMS28_porin		OMS28 porin	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.70	20.70	20.80	48.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.74	0.70	-5.31	2	39	2009-09-11 23:15:34	2003-04-07 12:59:11	8	2	24	\N	1	27	0	167.90	72	99.15	CHANGED	KIFSNLIINGLLFGFVSLNVFADSNNANILKPQSNVLEHSDQKDNKKLDQKDQVNQALDTINKVTEDVSSKLEGVRESSLELVESNDAGVVKKFVGSMSLMSDVAKGTVVASQEATIVAKCSGMVAEGANKVVEMSKKAVQETQKAVSVAGEATFLIEKQIMLNKSPNNKELELTKEEFAKV-pVKETLMASERALDETVQEAQKVLNMVNGLNPSNKDQVLAKKDVtKAISNVVKVAQGARDLTKVMAISLY	...........KhFtNLIIsGLLFGhVsLNVFADSNNsshlp.pSNVlEpsDQKDsKp........LDQKDQVspuLshIsKVTEDVosKLEtVRESSLtLVESNDAulVKcFVGSMSlhSDsAKGsVlASpEATlVAKhSGhsAEsAN+VVEhSKKAsQETQKAVSVAsEAhFLIEKpIM.NKSPNNKELELTKEEFAKVEpVKETLMASERALDETVQEAQKVLNhlNGhNPSNKDQhlAKKDVtKAISsVVKVA............................	0	1	1	1
+3579	PF02462	Opacity		Opacity family porin protein	Bateman A	anon	Pfam-B_2356 (release 5.4)	Family	Pathogenic Neisseria spp. possess a repertoire of phase-variable Opacity proteins that mediate various pathogen--host cell interactions [2]. These proteins are integral membrane proteins related to other porins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.62	0.71	-4.27	4	799	2012-10-03 17:14:37	2003-04-07 12:59:11	10	2	118	1	25	2965	35	133.70	47	70.81	CHANGED	sGYchs.shRlAsDYT+YtKhsus...............sosl+Gh.....................LGhSslYDFDTtSchKPYlGsRVu......................oN.thchossA+h.thcu....sScp+lGlGVlAGVpYclTsNlsLssGhcYNplGph.psopVpshtspsGlRapF	...........................................................................................................VGYD.FG...s.....W.....R...I..AAD....Y...A.S.....Y.R..K...Wsss...............................p.............s..p......p...l..ptp.ssstpp.p.pp.................................QtNGoFHAsSSL.G.L.S....A.I...Y....DF.K..L..N..D...K.F...KPY..I..G..A..R..V..A...................................................................................hs....ps....+....h..p....s.....c....o....s...p..s....t..p..p..t...................................................................................................................................................................................................................................................................	0	4	9	13
+3580	PF01160	Opiods_neuropep		Vertebrate endogenous opioids neuropeptide	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	21.00	21.50	19.60	18.40	hmmbuild  --amino -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.01	0.72	-4.20	31	202	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	67	0	73	181	0	44.50	39	20.36	CHANGED	-CspDCutCuh+..spps.plNsLsCoLECEGcLsosctW-tC+clLpht	...............-CtpcCshCsh+..st...s.slNsLs.CsLECEupl.ssp..W-hCpphLp.h...................	0	3	11	26
+3581	PF04966	OprB		Carbohydrate-selective porin, OprB family	Bateman A	anon	COG3659	Family	\N	19.80	19.80	19.80	19.80	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.98	0.70	-5.31	48	1348	2012-10-03 17:14:37	2003-04-07 12:59:11	7	5	568	0	433	1321	465	361.60	17	76.71	CHANGED	cpshthssphthshshDLp+lhGh.cusphphs...hhpppGpslsss......hsshtshpplhGtt.......................................pthRLs.phhhppphh....................sspLsl+hGphshsspF.......................hssshsspFh.....shuhsusssss.........hsshhhsaP...hushusplchp.ssp....hhlpsGsacssssshss.............pGhsh........psssGshlssEls..ap.t......................................httsthsGpYclGuahssuphsshh.shsh....h.....................ts..spptp......................................uptGhahshpQpltpsss..........tsLslFupss............husssssh.....hsttlshGlshtGshtsRspDslGluhuhtphsspsptttt.ht..sh..............tssEhhhElaYphplsstlslpPslQYlhpPuss...........sphssuhlhG.l+hphsF	............................................................................................................................................................................................................................t.t..tph..thph-LtthhG...h....pshphphs.....hhp.t.ps.h.shosp.................s..ts..h...s..h..pt.hh...utt...............................................................................................................ph.+Ls...phhhp.p.p.h................................tspL..pl..cl.Gphs.hsp..a........................................................s.sh..t.spFh.........................shsh.s.s.s.s..sss..........................hst.hh...s..aP.......tthus...pl.....ph..p.sst...................hhh.p.sGsa.p..ss..ss....s.hps...............................puhsh........................ttssGh..hh...hchs......at.t......................................................................s.s.th...sG.p..a..phu...s......h.h..s.ssp.h.s..sh.......h..s...t.h...............................................................s..pt.tp.............................................................................s.p.huhh.hshp.Qtlht.s.................sl.slhu.phs................................hsss...s.s.sh..................hs...h.thshGhsh..tu..h.....tRss....Dp...lGluh..u.h.t.h...ssp.h....p....th...t..t.................................pssphh..hEhhY..phpl........s..s........t..lp..lpPshQalhpP..uts.............pth.sssh..lhG..l+sphpF...............................................................................................................................................................................................................................................	0	101	252	353
+3582	PF03573	OprD	Peptidase_S43; 	outer membrane porin, OprD family	Griffiths-Jones SR	anon	MEROPS	Family	This family includes outer membrane proteins related to OprD. OprD has been described as a serine type peptidase [1]. However the proposed catalytic residues are not conserved suggesting that many of these proteins are not peptidases.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  --amino -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.97	0.70	-5.68	47	2107	2012-10-03 17:14:37	2003-04-07 12:59:11	8	5	748	29	364	1637	75	371.00	27	90.15	CHANGED	tGFlEDSpsslphRNaYhNRDa+ss......ss.t...........upp-..EWuQGFlhsapSGaTpGsVGFGlDAhGhhGlKLDuGtuc..uG.oGl.......LP......hs.sD....Gc..ssDcau+hGs.ssKhRlSpTpLKhGc.hhPshPlltssDuRlLPpoFpGstlsSpElcsLsLpuGphspss.Rssoshc.chsh.ht........sussucphsasGGsYphs.cphosuhahucL-DlacQpYhulsashPluts.sLssslphacocDsGp....u....................thG..plDNcsaSshhuhph.GuHohsluaQ+ssGDssasYls..............G.ssshaL..sNsh.huDFssssE+SWQlRYDhsFushGl.....PGLoaMsRYlpGcslcssss....................s-G+..-WER-h-lpYVlQSGshKsLul+hRpuohRssh..........sschDEsRLIVsYslsl	........................................................................................................uFl-Dup.hshthh.h....hpR.Dh+ss..................st...............thpp......chsp..u...hhLs...apSG..a.......st.......s.......h.......l.......G...hG..lDs..huh..hulcLsssssp.....us...sth................h..............p.....ss.....tt........scsa.......u.......c.........h.G.....s.....s........sKh..+..h....u....p..o....h..l..........+.........h..Gp.h...........s.p.h.Ph...lhss.stRhlPpoap....G....s....t....h....s.s....p....-.h...s......s...L..shpshh....hs.c.hpt............sp.s..s..h....c....chh.ts....................................tsspscth..p.hhGu..p..Y.p........h.....s...ss.h.s..hphh.huphc-h.........hcQ...haht.h.sap..h.s..lu..s......sLsssh..p.ha....tsc....-c..Gs......u...........................hss...th...D.sp....s..a..s..tt..h..o..hsh...t..s..t.....ph....t..h....sa..t..p.....s.....s....G...sp...u.....a....hht.................u..sssha.h..........hu....D..F.s.s...ssE+oh......h..t..hsY-hts.h.s.l.....P..GLs.hhs..p..Ylh...G.shcsssh......................tphc..ch..thshphsYslQs.G.......hKshth+h+...s.hc.t.......................................................................................................................................................................................................................................................	0	43	136	258
+3583	PF03169	OPT		OPT oligopeptide transporter protein	Mifsud W	anon	Pfam-B_3048 (release 6.5)	Family	The OPT family of oligopeptide transporters is distinct from the ABC Pfam:PF00005 and PTR Pfam:PF00854 transporter families. OPT transporters were first recognised in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP [1].	24.50	24.50	24.50	24.90	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	624	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-13.07	0.70	-6.09	45	2900	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	1215	0	1473	2844	385	534.50	19	86.15	CHANGED	phThRuhllGlllsllhussshhhuh+sshlshsslsstlluasls+hht..................................................h.hs.stPaohpEpsllpshus....uuss.h....shusshlhs..thhah..................tpph...shshtlhhshssshlGhhhushlR+hllhs..sphha......Psuhsssplhpshcpsp...............................................................p..hpph+hhhhshhsuhlatahsthhF.hlush.uhh.h........sthshshhhhths.........hshDashhh..lusshlsPhhsshshhhGslluahllhPlhhat.sshhsshhs.......h...us..............tshhhshtta.shushhhuuhhsl........hthssslspslhhphpsht...............................................t.......p-.ppphhpphc-.....................lP.hahhsshl.lshslulhhhhhhh..hphsh..........hulllulhluhlhshssuhhhulosh....ssul........shls.llhuhhhsup.................slAslhhsuhshsshupAtshhpDLKhGahh.tssPRthhh....sQhlGslluullsssVhphh..spt.hhss.........shshss.spshhhuulhhulhus.........shsahhlhhuhlhGhlhshlthhh....................tph.hPt..................lhhu.....lshhhssphss.......shhlGslhthhlc+...............................httthhpch.............shlluuGLssGtulhulllhhhh	..............................................................................................................................ThRsh.hlG......hlhshlhsshsh.....hhs.h+..ss.h....sslss............t..llu..hsl...hphh..........................................................................ts.hshhE.ps..................hl..phhus.......uuts.............hu.........s.hlhs......s.h...hhh.........................................................htth.....shh.hhhh..s...hss...t.....hlG..hhh..sh..............hR+.........h..h........lh.........sph.a....................Pp......shssstlhpsh.cptt................................................................................................................p..thphhhhshh...............hu..hh..ath........s...h..h.h...hs.....th..sh...................................h..h..t..h.......tht..........................hshsh...s.hh....lGs...s....h.l.................hs.hh......ssh.shhhGh..hls.ah..l..hhPh..h...h.....h..h..........h.........s............t....hs...................t...........................................phh..h..s...h.tah..sh..uhhhhs....u..h.hsl............................hthht..hh.ps...hh...t...hp..thh...................................................................................................................................................s.....t.t...p...h..t.t...pp..........................................................................l.s..h.hh.h.h.hhl.....h.hhh.h...h.h.h..h.....h..h........h....hsh..............hshl.l.shhluhh....hshs.suhh.huhss.......hsuh...................shl.s...hl.hu.hh.h..s.......................................shhslhhss............hsh.ssss....usshhpDhKhG.....ahh...ths...........P...tt..h..................uphlGshhushl.ss...........lh.hh...............shh.hs..........................s.shs..s.sp.shhh...........s.slhhulhss............................................sh..a.th...l...hh...shhhGh.hh.lhs.hh..................................thh.hP.......................................lhhu......hs.h.h.h.s....t..hs.h....................h.hl.Gh.h....ht.hh...hp...c.......................................................................hh..t.thht..ph.................................................................shlhuuGL.sGtulhullhhhh.h..................................................................................	0	399	892	1266
+3584	PF04069	OpuAC		Substrate binding domain of ABC-type glycine betaine transport system	Kerrison ND, Finn RD	anon	COG2113	Family	Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation.  This domain is often fused to the permease component of the transporter complex.  Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis [1]. The family member OpuBC is closely related, and involved in choline transport.  Choline is necessary for the biosynthesis of glycine betaine [2].  L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.64	0.70	-5.04	87	7137	2012-10-03 15:33:52	2003-04-07 12:59:11	7	15	3034	55	1357	6630	3203	253.50	21	72.82	CHANGED	sslslusts.as-shhhuplhtplLcpt.Gh.sschsshss.ss.hhsul.ps..G-lDlhs.tahsss......................hpthtc.thtpphshhh.s.shhhssp.uhsVsphhsc.............sl...polsDL.........tphss............shsschhsts.sGhs.......shhcsY.Gl......hh..ushtsh.s.....tlhpAhcptc.shlshsasscshhsph....c.lhhLc..................................Ds...+shhss.....tpltslsp.pshtcctPp.ltphLpplp..l.sscphpplttplst.pttss..pp.sAppalpp	............................................................................................................................slplusts...h.sE.st..h.h...s...p..l...h..p...p..l...lE...pt...Gh...ssp...h.h.s..h..s..s.......sh.hapul..ts........G..-....lD.l.hs.pas.sss.......................................................................hpt.hp....p...ht.t..p...h.thhh.h.s....shh.h.s.s.s.h...u..l..sVspth..up....................................t....sl...polu.D..L.........................................tchtt................shsschhs..pt...sGhs...........sh..h..c..s..Y...sl...............h...s.s...h.s.sh.s.............hhhpAh.pps..c...hsshhs...a.s...s..c..s..h.....h..s..p..h........c..l..t..h.Lp..........................................................................................Ds.......cp..h..hss......................hp.s.s..s.lsp....cs....hh...c.c....p.Pp..ltp.h.l.splt.......l.ssp...phpphphpl...ps...ptt...ss.....pp...sAcpalp......................................................................................................................................................................	1	350	775	1085
+3585	PF01718	Orbi_NS1		Orbivirus non-structural protein NS1, or hydrophobic tubular protein	Bashton M, Bateman A	anon	Pfam-B_1752 (release 4.1)	Family	This family consists of orbivirus non-structural protein NS1,  or hydrophobic tubular protein. NS1 has no specific function in  virus replication, it is however thought to play a role in  transport of mature virus particles from virus inclusion bodies  to the cell membrane [1]. Orbivirus are part of the larger reoviridae which have a dsRNA genome of at least 10 segments encoding at least 10 viral proteins [1]; orbivirus found in this family include  bluetongue virus, and African horsesickness virus.	25.00	25.00	111.40	111.20	18.80	18.40	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.23	0.70	-12.87	0.70	-6.48	7	185	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	65	0	0	167	0	452.80	51	99.24	CHANGED	MERFlRhFplsuptA.tlRhhtsISspWTCSHh+RsChhpGhCs+QpFpps.s.tshcpt-hstAp+llclAtphhhsRpclWhpshpshsp.hs-phtpchppshppL.-sYppSshpcchtshhphpcssp.lhhDDShShh.hhYhPhspss.spssplsRhtphhhsFYsspsscs.hl..pp.thcthhsphhp.stctlspC.aTGsptsl.tlhahP.phhshhss.p.sphlhRhsphDlphIhphsh+c.sRlhhQRFGhcssu.sslaphhlt+lch.sh.pollpt+h.....psWpphhlPhlLhRthhhthhs.p.hhsahpschsCQsCaltptsphcplhllDsRsuElsG...ssshths+hhcHhDs-.ph.pht-LptsEhlsR.usHWhshsChoot-AlhlThh.IHRhlRGsGlhss.thp.uh.hLARshLhWt..ssttpSslFRLhCashhthpspspGphhsWtDLGsFhchlhcspcLs.s.sEchasshhchs.....LhYhpp....h+hsshs...tsthpptplhpllpt.hsh	....MERFLphaslsG-hANAsRhFhsISPQWTCSHLKRsCLhNGhCs+Qp.F-cs.h.tAT.Dsp-.tpAh+LV-LApcAhhDR-TVWLpshKshsp.hpppl-tphccpsspLh-s....YppSGhh-Eh.p.pthssspR.lhlDDShShhPYhYlPhppGp.hlssshlSRatQluahFYsssssDc..aIs.s.hGlRttpsplK+tlEcplss..CPYTGhpGRlhpVhaLPlphhshhchp-.Apph.RhAuhshp.hh+s..Gatct.RhlpQhFuh.sssEhslHphMLh+hch.scspolVphRhhpsGs.sWpoWhlPhhlhRpuh.t........p.E.llsaM.c+KhTCQ.lC.ahhc.t.h.ThsVlDs+hu.ELsG...soshhhs+h..HssNc.pV.ps+.LhhsE.ht+IsDHahhppCaTstEAlhsTAIpIpR.IRGsG.Wss.happuhhhLsRlllhW.h.shspRSAlhRLhCFshaGhtPpAcGph.DWssLGoFhc.lLcG.-Ls...EDEp.sahoMhcMs.....hhasp+....s+hsshs...tsshE.tpVhplsth..p............................	0	0	0	0
+3586	PF01616	Orbi_NS3		Orbivirus NS3	Bateman A	anon	Pfam-B_1029 (release 4.1)	Family	The function of this Orbivirus non structural protein is uncertain.   However it may play a role on release of the virus from infected cells [1].	25.00	25.00	47.30	47.10	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.13	0.71	-5.34	11	375	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	70	0	0	339	0	202.30	56	91.79	CHANGED	p-holhsh.....PPhh.soAPshs..........thpshuLslLspAhossTGAotspKcEKAAauuhAEAL+D..stslRpIKhpVsppsLscL+t-Lpsh+R+psll+hlhhlsuslslsoohlsuhophssplpphhptp...............hlshslpslsLhsTshhlhsu+hppplppplcRsK+-IhKRcoYssAAphshsuss.........thsLpsschut	.............s.............pP....PpYsPSAPhPS..........oMPTVAL-ILDKAMSNTTGATpsQKsEKAAFASYAEAFRD..DlRLRQIKRHVNEQlLPKLKo-LuGhKKKRAIlHhTLLlAAVVALlTSlsTLoSDhuVs..hKhNsTps-ls............ahKsLsshlGllNLGAThlMMsCAKsE+uLNQQIDhIKKElMKKQSYNDAVRMSaTEFS.........SlPLDGF-hP.h...............	0	0	0	0
+3587	PF00898	Orbi_VP2		Orbivirus outer capsid protein VP2	Finn RD, Bateman A	anon	Pfam-B_1525 (release 2.1)	Family	VP2 acts as an anchor for VP1 and VP3. VP2 contains a non-specific  DNA and RNA binding domain in the N-terminus [1].	18.40	18.40	18.40	18.50	16.10	17.90	hmmbuild  -o /dev/null HMM SEED	946	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.48	0.70	-13.27	0.70	-7.02	25	468	2009-09-11 12:16:15	2003-04-07 12:59:11	12	2	67	0	0	373	0	558.40	24	90.95	CHANGED	uLLs+YPLAIplsVKl-D.GG+HsllKIPESDMIDlP+.oIlEALsY+PtRNDGlVVPRLLDITLRAYDsRKSsKsA+GlE.FMTcs+WMKWAIDD+MDIQPLKVoLDcasS.VNHQLFNClVKAcSANADTIYYcYaPLEsusK+......CNHTNLDLLRSLTssEhFHsLQGAAYuLKoTYELVsH..SERcshSEoYpVGspcaIpLpRGT+IthpGpsYE+FlSSLVQVllcGKlP-cIRsEIApLNc...I+sEWhsAsYDRs..+IRALELCKILSsIGRKMLDs.....pEEPKDEMsLSTRFQFKLDEKFh+sDpEHlNIFcVGusATD-GR.FYALIAIAATDTQpGRVWRTNPYPCLRGALIAAECcLGDVYhTLRpsYcWSLRP-YGp+ERsLEsNK.YVFuRlNLFDoN.LuVGDcIIHW+YElhps..+ETTaDcGYhCsppt..s.DDELlCclDED+YKEMhDRMIQGG.WDQERFKLHsILT-P.NLLTIDFEKDAYLssRSELVhPsYYDKWIsSPMFNARL+Is+GEIAThKuDDPWssRuV+GYIKssuESL-YsLGsYYDLRlpLaG-sLSLpQcQS..AVFpahuQpDDFusLTchppGtsVCPHS....GGshYTFRKVALhlluNYE+LsPsLHEGhEccpYhHPu...lsstac++VLEM+DhSQL...ICFVFDYIFEK+pQLRss+EARhIlYLIQssoGstRL-VLccsFPNFhc+lhsL+-lKplpDLNVIN.FhPLlFLVpDNISYhHRQWSIPMlLFDcs.IRLIPVEVGAYANRFGhKSFhNFhRFHPG-uKK+QcADDsHKEFGslsF-YYssTKISQGplcsPVVToKhDsL+lHlASLCAGLADSlVYTLPVAHPKKsIVLIIVGDDKLEPplRSEQIVs+Y.aSR+HlsGlVSIsVsQsuQL+VHopGIs+HRlC-KsILKYKCKVVLV+hPG+VFGNDELMTKLLNV	..................................................................................................................................................................................................................................................................................................................................................hhhp.t.s.....-sh.h.p..sht..............Hs..thh.phh..t...h.pthsYtht.p.hplhsh.......sp...tphp.....c.....h.s....p..h..t..h.....+th.h........tt.tthphhh.......tshs.......hphph..........................t...............tp.......h.plp................I..ptp....http.s....p....p.sp.lpthht..hh.p.......p.tsts.p.shp.+Fphpl.tph...pstch..I.ht..tttthsp.t+.FhsllhlsssDs.pttha....h.hlhhhh...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.ptt....hh....p...hphhhus.CtGht-.h..hhPhtpP..shlhh.h.s.......t.t.h..hh....p...thh.l.lt...............tt.................................................................................................	1	0	0	0
+3588	PF01700	Orbi_VP3		Orbivirus VP3 (T2) protein	Bashton M, Bateman A	anon	Pfam-B_1622 (release 4.1)	Family	The orbivirus VP3 protein is part of the virus core and makes a 'subcore' shell made up of 120 copies of the 100K protein [1].   VP3 particles can also bind RNA and are fundamental in the  early stages of viral core formation [1]. Also found in the family is structural core protein VP2 from   broadhaven virus which is similar to VP3 in bluetongue  virus [2]. Orbivirus are part of the larger reoviridae which have a  dsRNA genome of 10-12 linear segments [1]; orbivirus found in this family include bluetongue virus and epizootic hemorrhagic  disease virus. 	25.00	25.00	48.40	47.90	23.50	19.20	hmmbuild  -o /dev/null HMM SEED	890	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.54	0.70	-13.39	0.70	-7.12	7	204	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	66	2	1	161	0	531.10	67	98.12	CHANGED	ssuPYLcGDplpsDsGPLLSlFALQEIhpKVRpsQtchtstupEl-sshP-VppIlssl+sLtcp+sY+llppPshSaRaIshQSp-RhhRVsoaaERhSplG-shcpp-PhcFhssllc+V+alRscGuFlLaslsT+.hcGtEls-s-sLGV-hpshhssLsA.sRthlQstLsuhlIpNtpsscp.VDVa.GACsDslYRlHstLpuYlEssQhtphRpulsWLpphGppKRIpaspcaLTDhhpuDTIalLohpLPsNPpVIW-VPRsuIuNLIhNhALslPTGpYluPNPRIsSITlTpRITTTsPFA.LpGhsPTAtQMsDVRKIYLALMFPNQIlLDl+.-PGHplDPllphVuGVlG+LhFoaGPRhhNITpsMAp.LDhuhscaLhaMhssRhplpaGsoGcPLDFhI..GppQaDCNthtss.pTGpGYNGWu.VDs.tccPoPYsHVpRhIpYhshDScElID.RhhG.shsY.happMhchLltAG+ssEtsYhctML.aHhVRFA+INQIINcDLlSAFShPD-pFshhhssh.pssattssPlVLDlSahSIWFAFphRF.PssRs-hl..tPLlESVYAScLSlhKlcsppLphhhspsP-shlpA+PochWKAVhcp.PEPl+slhsLstp+sFlshRDlhpWlppsthQcSLhhhh-cEAWtsssD.pDLMhsccVYhHRp.lPEPhLDDlcpFRR-uFYYTNMlDu.PshscsVhhohthhhlpAshGph+uAlRphlDDssal+hGssLRslhlcFF-ShPPp-lLpALPFsYpscE+sG.lshsol+hsspspsaaLlYNV-hsshPDphlslsPshshTKlalpp+lVcRVcsssALuVhN+cFluY+uKhRlMDlTpuLcsGsQLAuPos	....................................................................................................................................................................................................................................................................................................................PRstlsNlhhshuhs.Phs.ah.sss+Istlolstcls..psssFu.l.u.hsTt.QhsDVRKIYLALMFPGQIILDLKIDPGERMDPAVRMVAGVVGHLhFTAGsRFTNlTQNMARQLDIALsDaLLYMYNTRlQVpYGPTGEPLDFpI..GRsQYDCNsFRusFtTGsGYNGWuhlDVEhR-PAPYsHsQRaIRYCsIDSRElIpPtT.a.GhsMpYhhapcMh....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+3589	PF05059	Orbi_VP4		Orbivirus VP4 core protein	Moxon SJ	anon	Pfam-B_5992 (release 7.7)	Family	Orbiviruses are double stranded RNA retroviruses of which the bluetongue virus is a member. The core of bluetongue virus (BTV) is a multienzyme complex composed of two major proteins (VP7 and VP3) and three minor proteins (VP1, VP4 and VP6) in addition to the viral genome. VP4 has been shown to perform all RNA capping activities and has both methyltransferase type 1 and type 2 activities associated with it [1].	25.00	25.00	98.50	98.30	16.00	15.70	hmmbuild  -o /dev/null HMM SEED	644	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-13.16	0.70	-6.76	6	86	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	47	5	0	97	0	564.20	62	99.40	CHANGED	M-P.HAVLYlopsls.hLccuFLPIhcLsGtEsLNsLWhtpGpasTDhYshGslpKWoIRQLRGauFIFlup+.cpIphtDsshshDllI.Ppphscsps.KcFEThIGhcRVtLRKsFGDhLRsYAhpashpFHGSEAETL.hA-P+RH+VhGhPpsPPshsh.sph.ssapsDpPTDEKLVSMLDYllYSAD.plaYVGCGDLRTLppFt+RDp+RFsRVpWhCIDP.IuPEosssNVllhpthlssscDL+pahp.ssslE+lLIWDVpoDputhushEWEppphpEDcLGEpIAhuhpshhuhAlIKHRIPp.ocppapsaoShLlPQPGAPhsMYELRNlhRL-GaS+VDRoHIPcApspplptcDsRpLVcpaHGpsRG+pLK+slaEaLHIpRpsGLpHtu-.PRADLFYLTNppNts+hp-ItcVlEpSsIuTlWVGsc.hasYDDFsYsRpplML+Fsp+s+hVlDGNGhILaLMW+hs.schspclsYDPuWApsFuVlhh+shsss.VPDlSLCRFIGLRphSohLRlpocpVHchsDlLK+LGLDlSGHLFIuLhSuuYlhDLhWWhcMIh-WSlhs+ppKLtslpctpAEVIEW+E-+AsEPWHhhsDLhAALhthuch.ch.hhcp..uslppWl-hLR	..MP.EP.HAVlYVTpELsHllKpuaLPlWclpGsEoLN-LWLpNGKYuoDlYAaGclppWohRQLRGHGFIFlST+.KslQLsDllhsVDVRI.P+-lh+s.D...hKtFEs.IGRRRl+hRKsFGDhLRsYAa+hAI.hHGSEAETLNsANPRLH+lYGhPc.PPhYhEhtph..ts.FsDEPTDEKLVSMLDYhlYSsE.EVHYVGsGDhRTLhpFtKRSPtRF+RlhWHlYDP.IA.s.-sp..sNVhVHphhVsuK+Dlh+phNhLKRVERLhIWDVSoDRupMsDcEWEppRFAEDRLGEEIAhphuGhFS.AlIKHRIPp..h-pYHshSTYLhPQPGAssDMYELRN.hM+L+GYSHVDRphHP-ApVhplVs+DlR+hVEhYHG+D+GRhLKKpLFEaLHIhRcNGLhcEs-EPRADLFYLTN+CNhuh..slYcVh+KShIAThWVGps.LaDYDDaulPRuhlMLpsSa+DlRlLDGNGAILFLMW+YP.-hhKKsLsYDPuWAMNFAVohKEPlP-PPVPDISLCRFIGLRVESSlLRlpNPplHpssDELKRMGLDlSGHLYVTLMSGuYVTDLhWWF+MIL-WSups+EpKLcsL+cStAEVIEWK-pMAERPWHVRNDLIAALREaKh..KhthRps..Asl-SWL-lLR................	0	0	0	0
+3590	PF00901	Orbi_VP5		Orbivirus outer capsid protein VP5	Finn RD, Bateman A	anon	Pfam-B_1525 (release 2.1)	Family	cryoelectron microscopy indicates that VP5 is a trimer implying that there are 360 copies of VP5 per virion [1]. 	23.60	23.60	24.20	143.70	22.00	23.40	hmmbuild  -o /dev/null HMM SEED	508	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.52	0.70	-6.30	14	206	2009-09-11 01:23:19	2003-04-07 12:59:11	12	1	72	0	0	195	0	462.80	62	96.62	CHANGED	tLuRhG+phssALTSsTAK+IYpTIG+AApRhAESEIGSAAIDGllQGolcShlTGEsaGESlKQAVILNVlGss-shPDPLSPGEptltpKlcELEcEp+p-hlpp+HsccIhcKaGp-.L-clh+hhsspt+hpptEccQh-hLcKAlcuhtclhcpEscplpcLtcALp+EsptRTc-EscMlppaRpKhcALpsAI-lEppuhpEEAIQEhhshoADllEsAAEEVPlhGuGhAoulATuRAIEGuYKLKclIstLoGIDLoHLcsPcIpPphlpslLcpsst...lsDppLspultuKlctlcE.ppElcHlpppIlPclKKthc--cc....hts.pcphIHs+sh.paKlPppQpPpIHIYoAPWDSDpVFlFHsluPHHtscSFhlGFDLEl-aVaaEDlotchHtL.GuAppssGRoF+pAY+EFhphAhp.stssthHp+RLpRSpusHPIYLGShpYplSYtpL+pNA.plVpss-LQhHlLRGPl+FQRRsIluALhaGVcll	...oLSRFGKKVGsALTSNTAKKIYsTIGKAAERFAESEIGSAAIDGLlQGSVcSIlTGESYGESVKQAVLLNVLGuG--lPDPLSPGE+GhQhKl+ELE-EQ+sElVRlKaNccI..tc+FG...c-.LE-VYcFMsGps+pEttc-cQaclLpKAVsSYpKlltpEcpph+pLApALQ+Ehs-RTcsEppMVcEYRpKIDAL+sAIElER-GMQEEAIQEIAGMoADVLEAASEEVPLlGAGMATAlATuRAIEGAYKLKKVINALSGIDLSHLRTPKIEPshluThL-pcttc..IPDppLAhulluKtcuIp-NppEltHIcpEILP+hKKhM-E-+E....lpuh--KhIHP+lhM+FKIP+sQQPQIHIYoAPWDSDDVFhFHClS.HHtNESFFlGFDLuIDlVHaEDLosHWHAL.GuAQpAtGRThpEAY+EFhNLAlusshsothHtRRhlRS+ssHPIYLGShHY-IoappL+sNAp+lVYD-ELQMHlLRGPLHFQRRAILGALKaGsKl...........	1	0	0	0
+3591	PF01516	Orbi_VP6		Orbivirus helicase VP6	Bateman A	anon	Pfam-B_765 (release 4.0)	Family	The VP6 protein a minor protein in the core of the virion is probably the viral helicase [1].	20.00	20.00	20.00	22.00	19.10	19.90	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.03	0.70	-5.37	3	135	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	47	0	0	149	0	255.80	52	93.72	CHANGED	LLAPGDVIKRSSEELKQRQIQINLVDWhEScuuKE-..EPK-EucuEpp..lSDGEGsQpccGpKEESuKETcDAsVDRRlHTsVGSGSusKGSGERAsKcADtGDGKstGGGGDADcGuGATGTs.GGGWVVLT-EIARAIESKYGTKIDVYRDEuuAQIIElERSLQKELGISREGVAEQTE+LRDLRRKERs-s+IKAV.+GsRKp.Rpptcusup+EGVtEE.spEEso+IGITIEGVMSQKKLLSMIGGVERKsAPIGARESAVMLVSNsIKDVsRATAYFTuPTGDPsWKEVAREAuKKKNILAYoSTGG.DsKTEFLHLIDHL	................................LLAPGDVIpRSoEELKQRQIQIpLlDW.-s-s.t........Kcp....EsKt.E.scsctp........cDG.E.........G..s.p....p...c.supKcc....uu.....cE...s..pD..AssD..RRlcTsVGpGous+GsG.ERs....sc..ssD..t..............GDuKst....tGuG-s...ctGsGs....s........Gss..t.GtWVVLT-EIAcAIco+YGsclc......VY+s-..s....s....u..pIIplE+SLQKELGloREssAEQTEtLRcL+...R..Kc+st....s+s+...us.....t.....+...GtcK...p....tp.p...cu........s.u.p+.Eu...sp.c-.....s.........pcpss.....pl..u............ls....IEsVMSQKKLLSMIGG.sER+htsIsARESuVMLVSNsIcDVsRATAYFTAPTGDspWKEVARcAoKKcNIhAY.oS....oGG..D..sKpEFLHLIDHL........................	1	0	0	0
+3592	PF00897	Orbi_VP7		Orbivirus inner capsid protein VP7	Finn RD, Bateman A	anon	Pfam-B_1523 (release 2.1)	Family	In BTV, 260 trimers of VP7 are found in the core. The major proteins of the core are VP7 and VP3. VP7 forms an outer layer around VP3 [1].	25.00	25.00	48.60	43.30	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-11.96	0.70	-5.51	7	191	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	65	22	0	159	0	303.00	60	99.57	CHANGED	MDuIsARALoVlcuhso.pDsRsph-sss.-hhuIhlsRaNuhT.RsVohRPooptcRsphFahslDhsluAhslplu.l.PsYp.shtTlulLApsEIPYTspAhsclsRlouphsshtssRp.hh.a.ssptlhtPGpha.hsAups.pshsluushhplolssutpsplsshlhPspsDslMhhFlWpplppapsssGss.-susssplolsssphcAGs.lls..sG.AslslsssuspsuhlchpVhaYhshs.o.shYsshpsplhssYSY+s.pWauLRuhlLpphslPshhPPhhPss-tpplLsLhLlSpLtDsYsshpP.aslhus.sh.sphptul...shsAh+	........................................................MDsIAARALoVh+ACsTLp-sRlslEusVhElLGIAINRYNGLTLRuVTMRPTS.sQRNEMFFMCLDMhLuAsslNlGsISPDYtQphATIGVLATPEIPaTsEAANEIARlTGETuTWGPuRQPaGaFLpstElhQsGRaa.hRAuQslTuslsusshhQVShNAGARGDlQt.lFQspNDPh.MIYhVWRRIcsFu.spGNSQpT.sGVTVsVG.GVsMRAGc.IlA.WDG.QAslpVpNPstpsuMlQIpVlaYlShDKTLsQYPuLsApIFNVYSa+s.TWHGLRsAILNRTTLPNhlPPIFPPsDR-slLsll.LLSsLADVYoVLcP-FslaGVsshsGslsRAl...stsAY......................	0	0	0	0
+3593	PF02072	Orexin		Prepro-orexin	Mian N, Bateman A	anon	IPR001704	Family	\N	22.60	22.60	22.80	25.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.90	0.71	-4.34	3	54	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	40	4	25	44	0	111.00	55	75.78	CHANGED	MNsPsAKVsWAAVTLLLLLLL.PPAlLSLGuuAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQASGNHAAGILThG+Rt.ERPuTRhpsuhpChAustsoVoPsG+uuh	.....................htslhLLLLLLL..shLho.ussAQsLP-CC.RQKTCSCRLY-LL.....H..G..........A.....G...............NH..........AAGILTLGKR+sGs..s.sLQuRLQRLLpu.SGNaAAGILTMG+Rs.t-su.................................................	0	3	5	9
+3594	PF03827	Orexin_rec2		Orexin receptor type 2	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	28.20	27.00	21.90	18.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-8.88	0.72	-3.92	3	46	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	37	0	28	36	0	57.30	70	13.61	CHANGED	LGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNVSKLSEQVVLTSISTLPAANGAGPLQNW	.........LGVH++Q-DRLsRGRTSTESRKSLTTQISNFDNlSKLSEpVVLTSISTLPAANGuGsLpsW.......	0	1	4	12
+3595	PF02999	Borrelia_orfD	Mlp; Orf-D; 	Borrelia orf-D family	Bateman A	anon	Pfam-B_1511 (release 6.4)	Family	Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames called Orf-A, Orf-B, Orf-C and Orf-D. This family corresponds to Orf-D. The putative product of this gene has no known function.	21.70	21.70	21.90	24.00	21.50	21.60	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.29	0.72	-3.86	4	180	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	29	0	13	111	3	94.80	63	78.45	CHANGED	SLP-cPshPhhpTLpsLup.EApLu-YVMYL.sFLs+TKsKVN....DspYPca.Y.D.SThKDEpoIps...lKaNIslahcYIcKTKPIsctVYpKYS+Lph	......sLPEEPcPPIIpTLKSLAKYEsQLS-YVMYLlTFLuKTKVKVN....DPNYPEYsYPDLSTLKDEHSITu...lK+NIslYLEYIcKTKPIAcKVYpKYSpLKh...	0	8	8	8
+3596	PF04160	Borrelia_orfX	Orf-X; 	Orf-X protein	Bateman A	anon	Pfam-B_3014 (release 7.3)	Family	This short protein has no known function and is found in Jaagsiekte sheep retrovirus. Jaagsiekte sheep retrovirus (JSRV) is the etiological agent of a contagious lung tumour of sheep known as sheep pulmonary adenomatosis. JSRV exhibits a simple genetic organisation, characteristic of the type D and type B retroviruses, with the canonical retroviral sequences gag, pro, pol and env encoding the structural proteins of the virion. An additional open reading frame (orf-x), of approximately 500 bp overlapping pol [1].	25.00	25.00	96.40	96.30	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.04	0.71	-4.41	16	37	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	3	0	0	36	0	151.00	93	93.07	CHANGED	MQPtNPMIYITKIVILYACNLKF.VKLHGKLLNLsLLVLNSLFSLNMVSTLEVYALITSGKQMLLTFLNLDVLNMFMFLLTLFPIFSWP.FTLENQHVTVFNIhCFsFLLQEShKPL+QIMDLsILAVLFNVFVFL.KFIIKQtFLIIHRDKVL	MQPENPMIYITKIVILYACNLKFPVKLHGKLLNLALLVLNSLFSLNMVSTLEVYALITSGKQMLLTFLNLGVLNMFM.LLTLFPIFSWPPFTLENQHVTVFNICCFAFLLQESHKPLKQIMDLVILAVLFNVFVFLSKFIIKQEFLIIHRDKVL	0	0	0	0
+3597	PF04061	ORMDL		ORMDL family 	Wood V, Finn RD, Bateman A	anon	Pfam-B_4871 (release 7.3);	Family	Evidence form [1] suggests that ORMDLs are involved in protein folding in the ER.  Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).	21.30	21.30	45.20	44.90	20.90	20.80	hmmbuild  --amino -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.00	0.71	-4.61	37	393	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	252	0	253	347	2	131.30	48	74.56	CHANGED	NhNssWlst+.........GsWlhalllIhll+lhh.hlP..shosshuWTLTNlsaslsoalhFHhlKGoPF-h...stGsYcpLThWEQID...................pGsQaTss+KFLhsVPIlLFLlooaY...o+Yc.hhFhlNh.sslhlsllPKLPhhH+lR	......................N.NspWhsu+..GhWhhallllhhL+llh.slP..hhSsshuWTLTNlha.hu...............pYlhhHhVKGTPF-t...spGthctLThWEQlD...................pGsQa.T.......soRKFLhllPIlLaLluoaY...T+.YD..h..s..hFhlNh.lullsVllPKLP.hHtlR................	0	63	115	181
+3598	PF02784	Orn_Arg_deC_N		Pyridoxal-dependent decarboxylase, pyridoxal binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.64	0.70	-5.20	17	10956	2012-10-03 05:58:16	2003-04-07 12:59:11	11	31	6377	85	2329	7307	4527	211.00	26	55.03	CHANGED	Dlu...lp+ttthhpthhsh......hpshYAVKsssshsllplLschG..s....GhDsuSpsElphVLu....hGsssc+IlassssKstuplchAhpp....tlshhshDshpELcpltchtsct....plhlRlpss.-spspshlus.....KFGhshpp...stthlctApphs.lplhGlphHlGSths-hpsahpAspcshplhctht.phGh...hchLDlGGGasss.p...........s.phpchupslpsulcchhs.......ptspllsEPGRhhsus	.............................................................................................................................h.....t.t....................ha..sh.Kss.p....t.l...lp.hh......h.....p.........G..................................sh-.ssSh.............sEl.h.s.ht..............hs..h...........s.......p....p......l.hhss.s....h....K......s.tt.l.p...h....A.h.t...................th.h.h.h.sh-.s..t-...l....p....h.lt...p.hs..th.................................tl.hlR.lp...........s......................t..t..t...s....t................h......h...s...s.......s.......t.....s.....KF.Gh.sh......p.............p..........h........h.t.h.l.c..t..s.p.p.......h.............s..l..p..l.h.Glc..hH..l...G..S....p.h..s.....c..h..c..s....ah.pu.....h.....p...c....s....h.......plh.sph..t......ph.............G...h.....p.................lphlslGGGhu.l...s.Yt.........................................t..t.........t...h....h...t........h.......t...h...h...pt...h.h.t...................plh..hEsGRhlsu............................................................................................................	0	749	1458	1952
+3599	PF00278	Orn_DAP_Arg_deC		Pyridoxal-dependent decarboxylase, C-terminal sheet domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	These pyridoxal-dependent decarboxylases act on ornithine, lysine,  arginine and related substrates.  	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.45	0.71	-4.37	105	9303	2009-01-15 18:05:59	2003-04-07 12:59:11	17	26	4591	89	2414	7018	3338	153.60	20	33.75	CHANGED	sLlspVhsh+p.st..........................................................................................tt.............hhh.lssGhhsp.hsshhhst....hhslhhht...............................................hpspstttsslsGsoC-usD.hl...sp.........chhLP.........plp.GDhlshhssGAYshshus.saNuhs..tsshlhl	..................................................................................................................................................................................................................hsplh.hcp..................................................................................................................p...................hhh.lDsuh.ts..t....hcsh.h....h.s.t........ha....l.h..s..lpt..................................................................hs.p..t..s....t..p...p..ssl.sG...hC-.osDhl..sp.............................................shtLP........................php.G.D.hL..s.hhssG..............AYsh.sh.us....saNshs..pss.h.........................................	1	788	1532	2038
+3600	PF02088	Ornatin		Ornatin	Mian N, Bateman A	anon	IPR002463	Family	\N	25.00	25.00	40.40	40.20	18.40	17.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.35	0.72	-4.39	2	7	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	1	0	0	6	0	37.90	75	84.39	CHANGED	l..Ct-h+E.GQPscKCRCsGKPCTVG+CshARGDssDKCh	L.YCG-FRELGQPDKKCRCsGKPCTVG+CphARGDssDKCh	0	0	0	0
+3601	PF02250	Orthopox_35kD		35kD major secreted virus protein 	Bateman A, Mian N	anon	Pfam-B_3549 (release 5.2)	Domain	This family of orthopoxvirus secreted proteins (also known as T1 and  A41) interact with members of both the CC and CXC superfamilies of  chemokines. It has been suggested that these secreted proteins  modulate leukocyte influx into virus-infected tissues [1].	21.90	21.90	23.60	22.30	21.50	21.70	hmmbuild  --amino -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.46	0.70	-5.05	5	131	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	30	7	0	113	0	211.00	44	89.18	CHANGED	hCopcEDs+YMGIDllhKV.TKpspTsssDshCQulp-lpESsc-tDEuoEctuTSTspGDshu...................oTYaTlVGGGLSlsFGFTGCPplsSlSEascGsaVYVRLSScAPW.+sTsslShNRsEAL.ulLEKCELSIsIKCSNpchsE.........TThsouoLsPcIopcsT-p...............uDIIGSTLVDT+CVcSLDloVcLGDMC...K+oS-LSlKDuhKYsDGELl....-DsuDsaslsSssLpAC	....................................................Cptctpphahthpl.h+l.s+ps.h.sssphC..hhphpps.....................-............t..s.ps-s.......................sshhSl.sGGLphshuahpC....+olup.sstsTV.A+huSlsPh..pscsss.uhT..+.....--s....l....thlc-C.VsIpl+Cs.-cpcs...............hhppssht.p.scpKs.s......................pcllGSh..I..VDscCVpslchpV+ItDhC...KppS.hpl+DhFphssGp...........................................	0	0	0	0
+3602	PF00213	OSCP		ATP synthase delta (OSCP) subunit	Finn RD	anon	Prosite	Family	The ATP D subunit from E. coli  is the same as the OSCP subunit which is this family. The ATP D subunit from metazoa are found in family Pfam:PF00401.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.82	0.71	-4.40	192	4976	2012-10-02 21:03:42	2003-04-07 12:59:11	13	14	4570	6	1207	3297	2540	165.70	25	84.70	CHANGED	lAppYAcALaclA.p.-.......ps..t.....l-ph...tppLptl..ssltpsscltphlssPtlsspp....Ktpllpp.lhps........................tl..sp.....hstNFlplLs-ppRlshLspIhptapp.lhsctcshhpspVpoAhsLsspptpplpptL...ppthsp.plplphplDssllGGlllcl...GspllDuSlpscLpplpppL	.............................................................................................................................................lup.YApAlaphA..h.c.........ps...p.......l-ph...tp...pLthl....thl..t..p...s..t.....p.l.tphLs.s....s....s..lsspp....+tc.hltt...lhsp..........................................th...st.....h.pN.h.l.p..lls.......-s.pRl.s...h.ls.p.l.........hppa.p.l...hs.p.p.p...sp......h....ps....pVt.S......A......hs..L.o.....c.....p.....p.hp.cl.tpt..l.............pc..p....h....u.....p.....p...l.p.l.p..splD..sl.lGGlllcs..........G...c.....p.....llDsSl+s+Lpplppt...................................	0	405	776	1019
+3603	PF02566	OsmC		OsmC-like protein	Mian N, Bateman A, Finn RD	anon	Pfam-B_2694 (release 7.0)	Family	Osmotically inducible protein C (OsmC) (Swiss:P23929) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein (Swiss:O68390) that  has a novel pattern of oxidative stress regulation [1].	22.80	22.80	23.10	23.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.55	0.72	-3.82	173	7485	2009-01-15 18:05:59	2003-04-07 12:59:11	14	22	3139	56	2170	5359	1255	100.10	21	63.21	CHANGED	ussp.....ussPh-llhuuluuChshshthhsppp.th..pl..psl....plplp.......h...chs.t.................hpplp.....lplplthss......s.......pphpchlpts.pchCslt.psl.ptssplphp	.........................................................s.tsp...ussPt-LlhuuhuuChshsl...thhhpct..th...sh.....ssh............plpsp............s............pts.ps..s.t.................hpplp......lphpl..p..hs..s.........hs.t........pph.pcll..........p....hu...c....phCslu.psl..psslslph.p..............................	0	654	1315	1789
+3604	PF03207	OspD		Borrelia outer surface protein D (OspD)	Mifsud W	anon	Pfam-B_2915 (release 6.5)	Family	\N	25.00	25.00	66.10	66.00	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.91	0.70	-5.23	2	24	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	13	0	1	22	0	218.40	86	98.61	CHANGED	MKKLIKILL.SLFLLLSISCs...........L.......DNEGsNS.sYESKKQSILuELNQLLtQTTNSLKEAKNTTDNLNASNEtNKVVEAVIssVNLISSAADQVKuAppNMHDLAQMAEIDLEKIKpSSDKsIhAuNlAKEAYsLTKAsEQNMQKLYKEQpc..co.S-SD.........hpsSsEIKQAKEAVEIAWKATVcAKDcLIDVENsVKEsLDKIKTETsNNTKLsDIcEsAELVLQIAKNstEIsQEVVAh	MKKLIKILL.SLFLLLSISCs..................LDNEGsNS.sYESKKQSILuELNQLLtQTTNSLKEAKNTTDNLNASNEANKVVEAVIsAVNLISSAADQVKuATKNMHDLAQMAEIDLEKIKpSSDKAIhAuNVAKEAYsLTKAAEQNMQKLYKEQpc..co.S-SD..........psSsEIKQAKEAVEIAWKATVcAKDcLIDVENsVKEsLDKIKTETsNNTKLADIcEsAELVLQIAKNsKEIsQEVVAL...	0	1	1	1
+3605	PF02471	OspE	OspEF; 	Borrelia outer surface protein E	Mian N, Bateman A	anon	Pfam-B_962 (release 5.4)	Family	This is a family of outer surface proteins (Osp) from the Borrelia spirochete [1]. The family includes OspE, and OspEF-related proteins (Erp) [2]. These proteins are coded for on different circular plasmids in the Borrelia genome.	25.00	25.00	30.80	30.40	21.50	20.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.42	0.72	-4.17	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	28	0	4	77	0	108.10	74	60.70	CHANGED	FSEFTVKIKN.KDNsuNWoDLGTLVVRKEEDGI-TGLNsG.......hGHoATFFSlEESEVNNFVKAMTcGGSFKTSLYYGYK-EQSss.NGIpNKEIhTKIEsINsSEaITFhGD	FS-FTVKIKN...KD.NuuNWsDLGsLVVRKEEDG...I-TGLNsG........GHSATFFSLEESEVNNFlKAMTcGGSFKTSLYYGY+-...EQSst.NGIpNKEIITKIEpINsoEaITFLGD...	0	4	4	4
+3606	PF03968	OstA		OstA-like protein	Bateman A	anon	COG1934	Family	This family of proteins are mostly uncharacterised. However the family does include E. coli OstA Swiss:P31554 that has been characterised as an organic solvent tolerance protein [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  --amino -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.59	0.71	-4.13	50	3517	2012-10-01 21:43:16	2003-04-07 12:59:11	9	18	2150	10	780	2490	1095	121.40	23	30.26	CHANGED	pIcuDpt.phcp..pss...hshasGNVhlpQGshplpA-clhlhpstp............................tthpplpupG.....shhptphphsspthpupAcphpYp..stpchhhLps.sAhlp......psssslpGspIphshppph	..............................................................................................IpuD.ph.p.h..c......tss......ssaoGN...V.h..l..p..Q......G..s..h.p.l.p...ADclh..lppsps.........................................................................................................................pshp.plssts........shht..t.p.h...p....h....s.....s....c........h..c.G..pAsphp.Yc.....htp.chhhL...p...s....s....u.hlp..........................psspsl..p..G.sc.Ihaphcpt.........................................................................................................	0	220	460	635
+3607	PF04453	OstA_C		Organic solvent tolerance protein	Waterfield DI, Finn RD	anon	COG1452	Family	Family involved in organic solvent tolerance in bacteria. The region contains several highly conserved, potentially catalytic, residues [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.29	0.70	-5.38	45	2046	2012-10-03 17:14:37	2003-04-07 12:59:11	9	9	1874	0	426	1515	1009	363.00	25	49.70	CHANGED	ppRhh.hthpppttlss.sap........htl-hshlSDp.sYhpDhsss.............hshtspsp.L.p..............puphsY......ttt.h.hshp..sppapsl.............tttpsspP....aptlPplshshhtsphh.....shphshpuphspFpcpstth.................................pusRhphpPplshshppshGh.lssphplp..tsh..................Yphststs..t............shspshsRslPphsl-sshshtRshph..................tappoLEPchtYhh.....hP..p..........sQssl..P..........saDos.hphshtpLFpps+asGh.DRIssuNplohulosph...hcsssh........................phphslGQhaahpsppshh.................sp....ss.ppstSshhsphshphspthphsushpas.pspphppsssshpYps...p...sthlslsYpahpsphttt...........................hpplshsstaslsp............pW	.......................................................................................................................pRhh.hhhpcst.shsp..sap.........hslDh.spV..S..D......sYhpDhssp........................hsssossh..hpp...........................phplsY..............ts..psh.s.hslp.........sppaQsh......................ptps..sps..........YpthPpl..shsh..htsshh...............shchph.uph.spFh..ps..p..t..s.s...........................................pusRhphpPslshPhs...sshG...lss.ph..p..lh........sst...........................Y.ptsp..s......t.............................phpcs.ssRshP.p.h.pl-s..ths....a.....-Rsh..ph....................sa...p...QTLEP+hpYlY.............sP..h+................sQs.sl...................saDos.....hp..............s.hssL.F....p...sp.pasGh..DRlssuNplohGloo.Rh....h-sss..........................................E+hshslGQ..haYhscppst.......................................................p.......sspps.s.pss.hs.s.phthph..........spphshpushp.....Y....cs.c...s....p..hspus.sshpYp......s.......pphlplsYpYtssp....hh..t.tt.......................................lpQlshsuta.lsspW..........................................................................................................................................	0	113	246	338
+3608	PF00865	Osteopontin		Osteopontin	Bateman A	anon	Pfam-B_1593 (release 2.1)	Family	\N	25.00	25.00	28.50	28.50	24.40	24.30	hmmbuild  --amino -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.47	0.70	-5.17	7	105	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	40	2	25	108	0	216.10	52	93.19	CHANGED	K.AsSGSSEEK.......h.pKasDAVAThLpPDPSQKQshLAP..QNshSSEEsDDh.KQpTLPSpSNESp-phDD.DDDDDD.DHssSpD...Ss-S--sDpsDD.cpsDESHHSDESDE.VssaPT-.stspVhTPslPTs-ssD.GRGDSVAYGL.RSKS+pF+hSchQhP..DAT-EDlTSHhcScEhsss.KsI.VA.cLphPSD.DSptKsSpEoSQlD-pSVETcS+EQS+pac.+AsDpSs..................E+SssIDSQEs..SKsSpE.p...F+SHEDKLs.D.KS.E-D+HLKhRlSHEL-SuSSElN	............spSGSSEEK.......h.shass.luoWLpsDPSQKQshLAs...QNslSSEE.psD..cQpTLPSpSN.ESH.-chDD.DD-DDs......SpD...Ss.-.............sD-S+cSDESDEhVs.cFPT-.ststsFTPhlPThss.s.GRGDSlsYGL.RSKS+.phchs..s.Qhs..DuT-EDhTSchcS.tE.pts.csh.hsp.l.hsSs.cspt...ps...........S.....EsSQhD-.ShETpSpcps+.hp..c.spccSs....cpSs.I-SQEp..S+sSpE............hpStEc..s.D.+S.E--+aLKh+hSHEh-SuSSEhN.......	0	2	2	5
+3609	PF00185	OTCace		Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	29.40	29.40	29.70	29.70	28.10	29.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.01	0.71	-4.36	123	10559	2009-09-13 17:21:38	2003-04-07 12:59:11	19	39	4814	296	2543	7158	4618	158.00	28	43.70	CHANGED	cGl.clshlG......D.t.splspShl...hshst.hGh.c.lplsuPps..h.s.......t...h...........t..t.hplp...p..shp.culps......sDllasspht........................pEc.............tphcthps.aplspchlp..t.sps.c...sllhHsLPh.......R.....s.........................EloscVh-.....s.sp.ShlacQAcNtlasphAllhhl	....................................slpluhlG........D..thspsupShh...........hshsp..h....G...h.....s...lpls.uPcs...h.s..............................t..thl................t...ht..pt..G.......spl.pls.......p.shc..-u.l.c.s......s.Dl...lhss.pht........................cEpt...........................pc.hpt.hps....at...lspc..h.hp....t..sp....s....s................s.lhhHsLPs............R....s.........................h.E.l.os-Vh-..........u.sp.ShlFc.QAcNtlasptAllhh....................................	0	832	1612	2137
+3610	PF02729	OTCace_N		Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.90	20.90	21.20	21.40	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.81	0.71	-4.53	105	10527	2009-01-15 18:05:59	2003-04-07 12:59:11	16	43	4811	296	2554	7124	4842	142.50	36	39.25	CHANGED	+c.llsl.pD...hspc-lppllchAtph+c........thtpt................thLpG.+sluhlFhcsSTRTRhSF.EsAhppLG..upslhls...ssspl..........u+.........GEolpDTu+sluph.sD..slllR..........phppsslpph..Achs.....slPV...INuhs...stpHPsQuLsDlhTl...pcc	.............................................................+chLslpD.hotpEl.ptllchAtphKp......................ttppt............................hLcG..Ksluh.lF.c.sS..TRTRsSF.E.sAhtcLG..ucshhls....sssopl................................u+...GEoltDTu+...lLuph..sD....sIhhR................p.p.p.t.t.s...cpl.....Ac..au..............slP.V.....lNuhs....s......ptHPTQsLhDlhTlpE.........................	0	833	1616	2149
+3611	PF02338	OTU		OTU-like cysteine protease	Mian N, Bateman A, Finn RD	anon	medline:20130692	Family	This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-11.08	0.71	-3.52	51	2248	2012-10-10 12:56:15	2003-04-07 12:59:11	14	84	441	33	1395	2228	90	124.90	19	19.92	CHANGED	.uDGs.Cha+uluptlh..................plRpts.....sphht......................ppppthpphltsp.................hh..h.t.t....sWus.......................................plpl.tuhuphh..phpIhl..............h.tsht.....hh.p.h.....tthpptlplha.t.....stHa	..........................................................................................uDG.sCLa+.Alup...tlh.............................tptth.hp...plRpts............sphlp..............................................................pptppa.p...hlpss................................................ahpphtpss.....pW.Gs................................................................................................pl-..l...huluchh.....phsIhl.....................................hp....ttst.......h....t.......................t..........hhh.............t..Ha........................................................................	0	507	785	1100
+3612	PF00724	Oxidored_FMN	oxidored_FMN; 	NADH:flavin oxidoreductase / NADH oxidase family	Bateman A	anon	Pfam-B_642 (release 2.1)	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.92	0.70	-5.45	12	10595	2012-10-03 05:58:16	2003-04-07 12:59:11	15	107	3470	129	3408	9713	2738	312.00	28	71.36	CHANGED	pLFpPlclGs.hpLppRllhsPh.ophtutccG.lsp..hhhcYastRuphssshlIsEushlsspus.shssssslas-cpltpa+cls-AlHcpGuhlhlQlaahGtps..schhtpts.........sstss..hsss...............+tlot--Icphlp.paspAA++Ahp.AGhDuVElHuApGYLls.pFLsPtpNcRoDcYG.GShENRsRFsLEll-tlpcslGp-t.....luhRlSs.shhtst.tshtEs...h.hhhhhschthchhsh.phAhl.chspPt.htshpspht...p.tss...phl+phhphPllssGp..hsssp.tshl.htc..scsslluhGR.hlusP-Lsp+lccGh..p	.........................................................................................................LFpPhp..l....s........s....h.....pL.pN.R..llhuPh....s.........p.............h.......t..........u.........t...........t......s......s..................h...........s.........s......h.....hhta....Y..t..p.R....A..p..........s.s.GLl.......l..s.....t.u.s.t.l.s......s.......p.........u.......t.......s............h.....s.......t.........s....s.....s....l........h........s......s........p.......p........l..........t.....u....h.+...p...l....s.....c.....u............l..........H.............t...............p.........G.............u.........p..............h.........h....lQ.l......h.H...s.G..Rh..ut...........t...h....stt............................uss...............s..ht.t..................................s...........+th.o.p.c.-I......t...p...l..l.p.sFspAAppAh................c.A.G..............FD..............GVE.lHu..Ac.GY..L.lp...QFlos.hoN...p.Rs.D.p......Y.G....G...S.h.-N.....R..h....RhslEllc....A....l....p....p...s....h....u....s....c..h..........lshRl.....S...s..............h....c....h..............h..............p.......s.........s.......h......s.......h..p....-s...................ht.h.h..p...h.......h....t...t....h....t......h......p......h...h.....................................t...h.......u.........h..............h.....p..........h.......s...p.....................................t.....s..............s..h....t...........................h.........................t.t.l.....+...p......t......h.....p.....h..s...........l..l....s......s...Gt.....................h............s.....s...........p...........................A.................p................p.h........lt.p.....................G........t......s........D....h.lu..huRshls.sPchst+htps..........................................................................................................	1	954	1981	2860
+3613	PF00174	Oxidored_molyb	oxidored_molyb; 	Oxidoreductase molybdopterin binding domain	Sonnhammer ELL, Bateman A	anon	Prosite 	Domain	This domain is found in a variety of oxidoreductases. This domain binds to a molybdopterin cofactor. Xanthine dehydrogenases, that also bind molybdopterin, have essentially no similarity.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.09	0.71	-4.84	150	4576	2009-01-15 18:05:59	2003-04-07 12:59:11	14	45	2283	46	1578	3981	1512	159.10	27	44.65	CHANGED	hspts.hP............tl.s....tsapLpl.....s..G.......h.Vcpshshohc-Lt.p..hPp..tphss.slpCsss....................Wuh...h..sspWsGV.LpclLctsss...............p......su.........................paVhhpu.hD....................................................s.....YspulPl.scshc......................csllAaphNGc.....sLs.pHGhPlRLllP.shhGh+ss.KWlpcIplhsp..t......tu...aWpp	......................................................................................................psaplpl.........p..G......................V.tp.....s.....h..s.....hshp-Lh...t...h.s......p..p..h..h..h....p.h.p...........Csts...................................Wuh.....ss.WpGssLpclLp.t..s..ts..........................................................p...ssA.....................+aVtFpu.h-...........................................................................s..Y..s.p.u.l.pl..s.cA.hc.........................ts..llAht.h..sG..c.......sL.ss.p...p.G..t..P..lR.lll.........P........t......h.....h..G........h+.s.....s.K..hlhpIplspp...s.......sha............................................	0	442	944	1319
+3614	PF00148	Oxidored_nitro	oxidored_nitro; 	Nitrogenase component 1 type Oxidoreductase	Sonnhammer ELL	anon	Prosite	Domain	\N	28.60	28.60	28.70	28.60	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.07	0.70	-5.83	116	3989	2012-10-03 15:23:08	2003-04-07 12:59:11	14	13	1338	128	1280	3778	993	356.20	21	84.43	CHANGED	CshhGAh.hshhslcsshsllHGstGC...ssastshhspphc.............c.h............hhoTshsEpsslaG.GpcpLtculcplhppapP..chIslhoTChsphIG-Dlpulscph.....ppph......................llsssssua.sssp.pGactuhpullcpl.....................................................................................p.tpcst...............plNll.sshtls.....uDhpplccll.cthGl.........................chsshhsussslc-lpphspAphslshspp.htt....suchlcccaGlPhhp...ssshGlpsTsphlppluchhG................tt..h.sptltc....cc.sphhcthhc.h+....thlt...G.++.........sslhus..s.shshulsphlt.E.hGhcsshssstssstt.h..t........................................................ph.t.htt............lh.s..ch.h-lcph.lpphp..sDll.....lGssp.sphhucch...........h.hGhPhhsthsht.ptshhGYpGsh....plhcclssslh	.........................................................sthhGuh.hshtslcs.shhlhHGs.GC...........st.a.h.h.sh.ht.thht...................p.......................hh.sosh..pEpsl..l..h.G...up...ccL...h....csltphh...p.......h.....h.......t..P...............ph.lhlhsoCsstlIG-Dlpuhs.cph.....ptchsh...................sllssps...s.ua..sssps.tG.hchshp.ulh..chhhs.........................................................................................................................t.t..tp.t....................slsl...l.Gshshs.........u-h..hp...l+...tl..L...cph...Gl..........................................cl.shh.ss.s.s.s.hp-lt.ph......sp.Aphsl.......hhs...............t....ht...............huphhpc..c.h.uh.Phht...............................hG.h..pthtthlptl.sp.hhs.................................................................h....t.....ltt........tp....tt...h.......h...t...t....h.p....hp..........hht.........G..+p................hh.l....hss..s.....h.h....t...........hsphh...-....hGhps.hh.h.sh....h.t..ptt...........t........................................................th.t...htt......................lh.t...s..........p....h..phh....t.p........ht.............s-...lh.............h..us.h..tt..hh.t.ph.....................uh..P.hh...........h.hhGatGh..hhp.h.....h....................................................................................................................................	0	432	869	1085
+3615	PF00361	Oxidored_q1	oxidored_q1; 	NADH-Ubiquinone/plastoquinone (complex I), various chains	Finn RD	anon	Pfam-B_4 (release 1.0)	Family	This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.78	0.70	-5.13	33	91875	2012-10-02 00:39:38	2003-04-07 12:59:11	15	57	35037	6	4521	86901	9765	225.60	28	56.30	CHANGED	ussllhhaluaE..hhslssal.Llshattp.cuhpAuhphhlhstluShhLLhuhh..hlahhs.uohsa.tlhp...............s....hhhhhhlhluhhhKhuhhPhHhW..........LPcuhtusssssullhuuhhlhsulallhRhh.lh.......hh.hlhhluslohlluuhsulsQsDlK+llAYSoluphGa.hhshluh...s.h..tsuhhhhlsH.uhhpusLFhhs.shhhpp.t.........spslhhhs.ulhthhPhhthhhhlshhuhs..GlPsh....sGFhuKhhlltsh	....................................................................................upphh..h.ahh.hE.....sh......hh.......l....................h.................p............p........................p.........s.........h..............p..........A.....s..........h....p.hh.l.h..p.t.h.u.s...h.h....l..L..h.u...h.....h.........h......h................s......G......p.......h.....p..h..t..p..h.t.....................................................................................h........h...h.....h...h....h...hu.....h..hh...K.u.h..Ph..H.h..W..............hP.c.sh.p..u...........s......s.....h....s....u..h..........l..h...u.s.h.....h...h.s.s.h........h.l...l...h....ph...............h...............................................................h...l....h....h...l.u.lh....o.hh.h.u.u.h..hu..L......s......Q.....s......p.....l..+.....+ll.....A....aS....olu....p.h...G..h.........hh....hh.lhh......................ss.................t.....h..u....h.....h....p.h....h.s.....a....uh.h.p...u.h.l.Fhhh....s......h.p.p.hp................................spsh.h.hh....t......s.........h..h...p...h...h...P....h..h..s...s....h..h........h..l..shL.uls........G..l.P..P.h.............s.s.FhsK.hIlp..t........................................................................	1	1460	2936	3788
+3616	PF00662	Oxidored_q1_N	oxidored_q1_N; 	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	Bateman A	anon	Pfam-B_22 (release 2.1)	Family	This sub-family represents an amino terminal extension of Pfam:PF00361. Only NADH-Ubiquinone chain 5 and eubacterial chain L are in this family. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.03	0.72	-4.41	32	19906	2009-01-15 18:05:59	2003-04-07 12:59:11	15	26	14684	2	1246	18780	2012	60.60	42	9.78	CHANGED	hlphhpWhssps.hplshuFhhD.hohhhlslshhVohhlhhaSh.YMp.pDPphs.......RFFpYLth	..................................hhWsWh.h.s.....ss....F...slp..hu..a...hl..D..s..LoslhhhllohVu......hhVll.YS..ss..YMu...c..D....p...s.h.....................RFFsYhsh...............................	0	404	818	1051
+3617	PF00420	Oxidored_q2	oxidored_q2; 	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	Finn RD	anon	Pfam-B_193 (release 1.0)	Family	\N	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.15	0.72	-4.39	194	10049	2009-01-15 18:05:59	2003-04-07 12:59:11	19	10	7521	2	1437	7095	1962	96.00	27	90.05	CHANGED	hhhhshhhhFhlulhGlhh.RppllpsLlsLEhhhLulhlhhshhuh.h...........................................pshhsphhslhlLshuAsEuulGLALLVthhRsaGo-plpslslLps	................................................h.hhhhhshhFhlGl..hG..l..l.....h...Rp.....pllphLl..sLEhMhhulhlhhs.hhuh.h.........................................................................................................................................................tss..h..s...phhsl.hhl.shuA.sEuulGLAlllth.h..RspGosplpslshhp..............................	0	454	913	1189
+3618	PF00499	Oxidored_q3	oxidored_q3; 	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	Finn RD	anon	Pfam-B_61 (release 1.0)	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.24	0.71	-4.41	100	8649	2009-09-11 06:35:13	2003-04-07 12:59:11	15	6	7126	2	830	7391	1836	152.30	22	84.54	CHANGED	lhsslhhlh..s.psPlhhslhllhhslhhuhh..hhhhs...ssahuhlhhllYlGGlhllFlahssls......ssphhth.......................................................................thhhhhhhh.......hhhhhhhhhhhht.h.hths.ht..th..h...............................................hhssthh.hhh....hhslhLllslls..sltls	........................h..sul.hss.s.......s..ssPlaus.....LhLll.shhsssul..hhh.hG...usFlul.llhl.lYlGuhhVlFlasshhs............spp.hs.ct.h.t.p.h.........................................................................................................................hhhh.h..h.s.hhh.............hhh..h..h..h.....h....h......h....h......h.......h....t.......t.....h.........h....h.....s.....h.....s....s.....h...t...t..h..s..h..t..ht...............................................................................................................................hhth.la.o........h.sh..hhh......lsuh..hLLlsllssl.l.....................................................	0	275	538	685
+3619	PF00507	Oxidored_q4	oxidored_q4; 	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	Finn RD	anon	Pfam-B_68 (release 1.0)	Family	\N	21.60	21.60	22.10	21.60	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.52	0.72	-4.20	99	11473	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	9331	2	859	9513	1923	105.50	45	89.88	CHANGED	llshllhhl..............uhh.......ls......cph..t...-K.osaE.CGFcPh.spuR...hsFol+FaLlullFllFDlElshlhPhshhh.....tt.hhhh..hhhhh...hFlhlLhlG.lhYEWppGsLcW	...................................hh.luhlLhhl........saa..........Ls...p.....h.ss...ss.......EKhSPYE.CGF.D.Ph...Go..AR.............LP.FSlRFFLVA.ILF..LlFD..L.EIALL..LPhs.huh..........h.p.s....s...h.hs..........hhhs.h..hh.l.l.l.L.s.lGLlYEWt.pGuLEW...............................	2	284	563	713
+3620	PF01059	Oxidored_q5_N	oxidored_q5_N;	NADH-ubiquinone oxidoreductase chain 4, amino terminus	Finn RD, Bateman A	anon	Pfam-B_381 (release 3.0)	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.32	0.72	-10.67	0.72	-4.18	143	6646	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	4701	0	249	6505	763	104.90	37	24.78	CHANGED	MLKlllssl.hLlPhshh.t...hha...hhhshllhhlShh.h..hp.shthhhs.hhshh.huhD.lSssLllLShWLhPLMlhASppthpp.shtpp+hFlhhlhhLplhLlhT	.....................................................................MLKlllP.Tl..ML.hP..h.s.ah..s...p...hlW....s..shh.h.SllI.uhhSL....h......a............lp.................s..p................s............h...........t.....s..........hs.h.........h.husDsLS.sPLLlLTsWLLPLMIl.A....SQ.sH...lpp.EshsRp+..halohLlhLQ.hhLIhs....................	0	77	152	195
+3621	PF01058	Oxidored_q6	oxidored_q6; 	NADH ubiquinone oxidoreductase, 20 Kd subunit	Finn RD, Bateman A	anon	Pfam-B_1345 (release 3.0)	Family	\N	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.22	0.71	-4.54	169	7525	2009-01-15 18:05:59	2003-04-07 12:59:11	17	28	3465	80	2007	4724	2053	123.50	33	48.57	CHANGED	CsGC...shul.tshtsshh-lh.t..hp.........htat..slhssst..........................ptDlllV-Gul..ts......................pstlchlhcht.tcschllAlGsCAshG.Gl.shts.......sh...........................................slhp.........lsV...lplPGCPPpPctlhtslhtl	..................................................sC.slph..hssts.s...hhDh............................c.aG.h.hh.h.u.ust...........................................puDlhlVsGslspch.......................................................................................tPs.l.c.+..l.a-p.h.s.-P.+h.V..IuhGu.CAssG.Ghathts........sh............................................................................h..........lpGl-.ch...............lPVD..lalPGC...PPpP-shltulh..h...................................	0	667	1322	1707
+3622	PF01237	Oxysterol_BP		Oxysterol-binding protein 	Finn RD, Bateman A	anon	Prosite	Family	\N	25.40	25.40	25.40	25.50	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.26	0.70	-5.96	149	2468	2009-01-15 18:05:59	2003-04-07 12:59:11	13	56	312	10	1498	2357	5	330.10	27	52.43	CHANGED	ulhuhl+p.....slGpDLS+.lohPlhhsEPhShLQ+hsE..hEY.scLLspA...sp.................psDshpRhhhVss.aslSshssp..hpR.t.......KPFNPlLGETF....E.hsc..t.....shchluEQ.........................VSHHPPloAhascs..p.s...............aphtupstscsKFhGp.Shplp........hGtsh...lplpp........................................................................................t.........sEpYshsp..ssspl+sIlhGphalE.hGchhIpsp.........p..oG.pshlcFps.p.....Ga...huup...pp.........lpGt..lhc..p..............sspsha..plpGpWs.cplhhppsp...........................................................................ttpt.....phlWcssshss..p..pha.h..s.hs.hsL..Nt.....c..........plssTDS..RhRPDp+AhEpGch-tAspEKp+lEccQRptR+cc..............pppsp..pap.P+aF..pcs......................hpshstp................a.hpss......YWch	.......................................................................hhsll+p......plG.h.D.L..o..+...ls...hPs...h.EPhS..hLp+.h.s-.....h.p.a..s...c..L.l.s.p.A...s.p.............................................................p.ps.shcRhh.h........Vsta...hl..Su.atpp.......htpst...............................KPaNPlL...GETa..........................................-.h.p.....p............sh.ph.....l..uE.Q.........................V.SHH.....P.P.........loA..h.a..sps......ps...................hph..s.p...ht...h+.sK..F.........h.........G.p..S..lpl..h................hG..p..hp.......lph.p.....................................................................................................................................t......sEpY.hh.sh..ss..stl+..sI...lhG..p..ha..lEh.hG.ph...pIpsp.............................p.....ou..h..psplpF..pt..p.................................sa....h..u.s..ph.....pp................lpGh...lhs..t....................................stcs.h.h....plt.G.pWs.pp.h.h.httss..................................................................................................................................pt......phlacss....h.s........t..t..ph.h................L............c.........................................ssp-S....hh+...s.s.p........c..t......l.c.p...u.c.h.-t..AsppKp.clE-tQRtt...p+pc.........................................................p.p.p..t............tap.......s+......aF.....ppt.................................................................................t..............................................................................................................................	0	500	792	1157
+3623	PF00543	P-II		Nitrogen regulatory protein P-II	Bateman A	anon	SCOP	Domain	P-II modulates the activity of glutamine synthetase.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.23	0.72	-3.54	93	4823	2012-10-01 21:59:08	2003-04-07 12:59:11	17	7	2688	149	1478	2996	1680	101.60	53	82.59	CHANGED	IpAII+..P.KL--V+cALsphG.ltGhTVo-VpGhG+QKG..sElaRGs....................cahss.hlPKl+l-llV.sDctl-pll-sIhcsApTGc...lGDGKIFVtsl-..cslRI.RTG	....................................IpAIIKPFKL--V+EALscl.G.....lp........G.hT.V.o.E.VK.GFGRQK.G.H...TE.l...Y.RGA.................................EY.hV-..FLPKVK.lEl.........lV.s.D.-...l.-.p.ll-sIh...cs.Ap...T...GK........IGDGKIFVhslp..cl.lRI.RTG.........................	0	486	973	1256
+3624	PF04275	P-mevalo_kinase		Phosphomevalonate kinase 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Phosphomevalonate kinase (EC:2.7.4.2) catalyses the  phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate,  an essential step in isoprenoid biosynthesis via the mevalonate  pathway [1]. This family represents the animal type of the  enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see Pfam:PF00288).	23.90	23.90	24.90	24.20	22.70	23.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.53	0.71	-4.37	11	154	2009-09-10 15:39:43	2003-04-07 12:59:11	9	8	123	1	104	164	4	113.90	38	29.84	CHANGED	hSGKRKSGKDalo-+LppRLsts+sp..IlRISpPlKpcaA+chsLDhpcLLusGsYKEpYR+DMIpWuEpcRpcD.GaFCRtAhpps.......spslhIVSDsRRpoDlcaF+EsYG...hshsl	....................hoGKRKuGKDals-h.ltp.pL...st..s.....hst...........ll+lSsPlKcpYApppGL...DhpcLLssusYKEpaRt-MIpWu.EcpRppD....s....Ga....FCR...t...shcts...........spslhllSDsRRhsDlpaFpptas.......sthh......................................	0	32	52	78
+3625	PF04699	P16-Arc	p16_Arc; 	ARP2/3 complex 16 kDa subunit (p16-Arc)	Waterfield DI, Mifsud W, Finn RD	anon	Pfam-B_4180 (release 7.5)	Domain	The Arp2/3 protein complex has been implicated in the control of actin polymerisation.  The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc.  The precise function of p16-Arc is currently unknown.  Its structure consists of a single domain containing a bundle of seven alpha helices [1,2].	21.90	21.90	22.90	22.70	19.60	21.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.89	0.71	-4.20	36	389	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	277	15	237	330	3	143.80	37	92.13	CHANGED	psaR+lDIDsh-.-sh.c.stps............spsphtsptsplRshLpuGchttALphsLpssPhsucs.psK-tthpsVl-VLsuhKs....s-.IsshlcsL.....sppph.DsLMKYlYKGhusPs...............................stsp................hulLLsWHEKllpluGlGsIVRshoDR+TV	..........................................................................s.taRplDlDth-.pp..p.p....t..............st....sph......tsptspl.cshLp......p.....G.....ch.htALpssLc.s..s.Plssc....s....ssK-tshthVlcVLt..uhKs....s-...lp.psl.puL......spsth.DlLMKYlYKGhptss.......................................................psss...................................ulLLpWHEKhhthuGlGsIlRVlTsR+pV.........................	0	69	116	181
+3626	PF00864	P2X_receptor		ATP P2X receptor	Bateman A	anon	Pfam-B_1590 (release 2.1)	Family	\N	19.60	19.60	24.30	19.70	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.38	0.70	-5.75	19	762	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	78	7	284	674	19	263.70	36	83.68	CHANGED	F-YcTsK.Vll+shplGll.RllQLhllsYllGWVFlacKGYQppDssl.SSVhTKlKGluhsN.s........hht+lWDVADYVlPsQGsssFFVhTNhllT.sQpQGpC...........PE...lP-......stCspDss.CptG.sshtusGltTG+Cls....hss..sh+TCEIhuWCP..sEs-pt.Pss...shLtpAENFTlaIKNsIpFPpFshoKpNllsshssoalKoCpYctp..psPaCPIF+LGsllccuGpsFpclAhpGGllGIpIpWsCDLDhshppCpP+..YSFpRLDsp......pslSs.GYNFRa................................A+YYpc.sGsEhRTLhKuYGIRFDllVsGpAGKFslIPThlslGSGluhhGluollCDllLLahh..................+ppcaY+pKKFEplpcsp.phstpp......pt	..........................................................................................................................................pYpT.+.hhhpshphGhh.hhhphhlh.Yh.h.................a.shl.pKtYQt.-.......SoVhoKlKG.hs.hp....................................plhDss.-Ysh.P................p.........t..ssh.lh..Tph.hT.tQ..thC..............sE...................t......h.C....pDtt...C......G.............................u......p.G..h........TGpCl..........t.....tTCEl.uWCP.h.E.tt...........p...........hh.tA.sFTlhlKN.......pl.aPh..ap..hp.......p.......tN.....l.h........th....s.....t....Chap.....p....C....PlFclG.lhp.s......G.ts...F.........pp.........hA....p..........G.......GhhGl.ItWsCsLDh....p.C.Pp..YpFp.tL-..............h.....GaNF.R.a................................A+aah..........s......s..phRsLhKsaGIRhDlhV.Gp..uGKFshl.hhh.hssshs.h.Ghs............shhhDhlh..h......................t...Y.ttKhp.h............h...................................	1	76	97	158
+3627	PF04045	P34-Arc	p34-Arc; 	Arp2/3 complex, 34 kD subunit p34-Arc	Wood V, Finn RD	anon	Pfam-B_9846 (release 7.3);	Family	Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc [1].  This family represents the p34-Arc subunit.	19.70	19.70	19.70	20.20	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.77	0.70	-5.09	27	380	2009-09-11 15:40:12	2003-04-07 12:59:11	9	9	288	15	254	369	3	223.70	41	65.50	CHANGED	hlSlplKsap-LhptG......s.chLppcYushh........sssEsGYshoLhlDLp..phs.....ptpppllpcluhLKRsshAuPFcpsFpt.tphsp...................spphhsI+YRs..DEolYlcsptDRVTVIFoTlFpDEsDplhGKVFLQEFV-AR+ps...QoAPQVLaSH.-PPLElpshsssp......ss-shGYlTFVLFPRHhsptcpppsoIspIphFRsYhHYHIKCSKAYhHoRMRtRVs-FLKVLNRAKPEsts	..........................................................................lSltl+happL.paG......ApchLpctYGshl..........sssEsGYsholhlDLp..plP...............psp...........ppllpphuhLKRNshAusFEchFph.tphpp...................stphhsIpYRc..-EshYlc....s........ptDR.VTVlFSTlF+D-sDhlhGKVFhQE..Fh-..uRRts.........psAPQVLaSp.....-PPLELps.ssst.........sssshGYlTFVLFPR.H.spsptptpoIshIphFRsYhHYHIKCSK....AYhHoRMRt+sssFLpVLNRA+P-s.p..........................................	0	79	133	205
+3628	PF00067	p450		Cytochrome P450	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures [6].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	463	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.40	0.70	-5.97	50	39592	2009-11-03 19:16:01	2003-04-07 12:59:11	17	282	2977	873	20665	39656	2722	330.60	17	79.49	CHANGED	Psss..shPlhGshhplth....pphhtp.hpphpccY..GslaslhhGs.pshVlltshchl+clLhcps.thssc.t.shhtp...hhpspGlhhsss..scW+phR+hhhsshpsh...ph.shpphlpcpuppLlcplccpssps......hDhtphlsphshssIsslhFupphs.hp-pp...........h.phhphhpphhp..hhts.hhphh.hhs..hlhhhsspht+hhppshphhpshhpphlcc+cpslsss.................p.hDhlchhLht........tppst....phopcsltsslhslhhAGs-TTSooLpasLh.hLhcaP-lQc+lpcElcpll.Gptc.........tsshpDhsphPYlcAsl+EsLRhhslsP...tlsRtspp...Dsplps...ahIPKGTpVhlslhult+Dspha.ssP-pFcPpRFLscps................h.tpshtalPFusGhRsClGctlAchEhhlhLsplLppFplc..s.ss.hsh.pt.....llhhs.shplph	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................................................................................................................................................................................................................................................................................................................h................................+...t......h..................h............................................................h...............................................h........h.....t...........h.....................................................................................h.............h............................t.............h...................h...........h.....h.s..........................................................................................................h.......................................................................................................................................................................................................................................................................................................................h..............................................t........................h...........t.....h........h.....................t......h.....h......t.........t....t..........t.t..t.t........................................................................s...h....h....p......h...ht.....................................................h...s........p...p....l........h......t.................h............h......................h......h.........h......u.................G.........................-.....T..................o....s.........s.......s....h................t....h..h....h............h......l.....h......p....p....P...............p....h..........................p....p.........h.................p.....E........h.............t....h.....h....t...t......................................t.....t...t.......h..............p......h.............h.........h.......p...............t.............s.l...........p..............E........s.............h............R........h..........h..............s....s............s..........s.....................h..........h.........................R..h..s...h.p........................s.....h...........p.................l.........t...............s.....................hh.l........s.............t.................G..................s.................h...........l.........h..............h..........s......h...............h...................s............h..........p................+.............s............................p................h..........a....................p...............P...............p........p.............F...p......P..p......R...a......t...tt..................................................................t....h.....h.......s.........F....u.........h...............G............................+........................Ch...........G.......t............t................h...A..........h........hp.....h..........h.......h......h...h....s....t...l...l...t....p...a...p.h................................................................h................................................................................................................................	0	5443	11134	16825
+3629	PF00870	P53		P53 DNA-binding domain	Bateman A	anon	Pfam-B_782 (release 3.0)	Domain	This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.	20.30	20.30	22.60	22.60	18.80	20.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.31	0.71	-4.71	7	550	2012-10-03 00:25:27	2003-04-07 12:59:11	13	15	172	206	160	635	0	158.10	54	43.93	CHANGED	soVPossDYPGsasFcLpF.Q.SuTAKSVTsTYSPpLNKLaCQLAKTCPlplhVspsPP.GshlRAhAlYKKsEHVs-VV+RCPHHppss-.s-t.hAPsuHLlRVEGN.hupYhEDs.ThRpSVhVPYEsPQlGoEhTTlLYNaMCNSSCMGGMNRRPILTIITLEs.-GplLGRRuFEVRlCACPGRDRKTEEcsh	.................................................lPs.psY.G.atFpl.......tF...p....os..s.s.K....SsshT................YSs....LpKLasp..lAKT.CPl..plhl.....s....s...P..P....G...s...hlRAMslYK+spHhsEVV+RCPpHchs..p.-.....s.-s....hs.s.....s..pH.....LI.RVE...G..s.....tu.pY....h....-....D............T....h..RpSVlVPY....E...sP.p.....l...G.o..-......h.....T..T.lhY....saMCN.SSC..h...G..GMNRRPILhIlTLE.....s.........t...s...G.plL....GRpshEsRlCACPGRDR+s-Ecp.h......................	0	40	49	92
+3631	PF04636	PA26		PA26 p53-induced protein (sestrin)	Mifsud W	anon	Pfam-B_5416 (release 7.5)	Family	PA26 is a p53-inducible protein. Its function is unknown. It has similarity to Pfam:PF04636 in its N-terminus.	29.40	29.40	36.00	33.00	28.20	28.30	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.58	0.70	-5.79	13	327	2012-10-01 19:19:04	2003-04-07 12:59:11	8	4	116	0	185	285	7	362.70	43	81.45	CHANGED	tpGPSsFIPsp-llphsstscpppthhp-sh...GRh..........DplopVhGhHPpYLcpFh+optalhphDGPLPhsaRHYIAIMAAARHQCSYLVshHpp-FLpsGGDspWLpGl-asP.KLRpLs-lNKlLAHRPWLIsKEHIptLlK....s.GpssWSLuELlHAlVLlsHhHuLuSFVauCGlp.-hD.h....tstshps.........ss..spsps..............ph.sssshsssptstus....................................t-VEtLM-RMKcLpcp..pc-EuSpEEMsT............RFE+p+ppohhVh.........suscptcssssssluRal-DssFGYpDFuRRGppslP.TFRsQ.....DYoW.....................................EDHGYSLlNRLYs-l.....GpLLD-KFpsshsLTYpT...............hAs+ssVDToth.......RRAlWNYlpClaGIRaDDYDYGEVNQLL-RSLKsYIKTssCaPE+sTpc.YssahhpF+HSEKVHVNLLLhEARhQApLLYALRAIsRYMT	........................................s..............................p.hh.cth..t.G...Rl..........Dpls.VMsh.HPpYLpsFh+ophhlL..ph..D...G.P.Ls..h.aRHYIuIMA.AARHpCsYLlshahs...cFLp...s.......G.....Gs.....s........p........WL.p.G.L......c..sP.tKLppLs-lNKlL..AHRPWLlo.+..-.HIptLl+........................s..tcpsWSLuELl.pAlVLLsHhHuLu.SFsFGsG.lpsE.hc.....thu..s.hp..........................ss.sp.p..s....................................sss.st..p...t.....s..........................................................-lEsLMc+M.+..p..Lp...cp....p..p-ps..o.......pEE.hts..............................RF.Ehp+ppohhsh............................ss...c.....sl..pah-Ds.sasYp.DFs+..............+G..p....P..TFRsQ......DYsW.....................................E-HGaSLl.s..RLYs.-..h.....GpLLDEK....F....phshs....LTYsT...............hu..h...+ps..VDTo.hh.......RRAlW...NYlpChaGI.RaDDY....DY.G.ElNQLL-RshKlaIKTlsChP.E...+s..Tcc.Ysth..h..cp...FcaS....EKV.HVNLLlhEARhQAtLLYALRAIs+ah....................................................................................................................................................	0	56	73	122
+3632	PF02251	PA28_alpha		Proteasome activator pa28 alpha subunit	Bateman A, Mian N	anon	Pfam-B_2837 (release 5.2)	Family	PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.	21.10	21.10	21.20	22.70	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.11	0.72	-3.80	18	310	2009-09-11 04:56:17	2003-04-07 12:59:11	13	5	109	7	133	251	0	61.10	41	23.66	CHANGED	lss-spt.KV-sF....+ppLppEAEpLlusahPpKIhcLDsL.LKsstlNlpDLosl+us..LsIPIPDPs	.................p.-spt.cV-sF....RppLhpcAEpLlssaFPpKIhcL-sh.L.....+-stLNlp-Losl+u..s..LsIPlPDP........................	0	28	37	74
+3633	PF02252	PA28_beta		Proteasome activator pa28 beta subunit	Bateman A, Mian N	anon	Pfam-B_2809 (release 5.2)	Family	PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.	20.90	20.90	21.30	20.90	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.69	0.71	-4.74	16	411	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	150	7	201	352	1	137.60	43	56.79	CHANGED	ssG..hlssNcplhpllcplKPElppLhEphshlphWIQL.IP+IEDGNNFGVuIQEcslpclssVcocstuFhspISKYaspRGchVuKsuKhPHVtDYRphV+ElDE+pahpLRlhlh-lRNpYAhLaDlIhKNh-KIp+PRus..sptthY	............................................sG.l.sNcplh.sllp.hlKPElppLhEphsh................VphWlQhhIP.+..I..EDGNNFGVulQ.........Ec.s...lpclpslcocstua...hspI..S+Ya.pRuchVuKsuK.P.H.....V.....tDYRphVpEhDEtpYhplR...............lhlh-lR.NhYs...LaDlI....KN...h...EKlppP+up..pt..hY.................................................................................	0	70	89	138
+3634	PF05138	PaaA_PaaC		Phenylacetic acid catabolic protein	Bateman A	anon	COG3396	Family	This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid [1]. These proteins may form part of a dioxygenase complex.	27.60	27.60	27.80	28.70	27.40	27.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.49	0.70	-5.43	117	1413	2012-10-01 21:25:29	2003-04-07 12:59:11	7	4	637	42	464	1179	369	266.20	33	88.22	CHANGED	M.................................................thppsLhchlhphADssllhupRhuEW...hu+APsLEc-lALsNhu.D.lGpuphhashAtp.......................L.....s..G..........pscDcLAahRpstca..+NhhLhEhPss...........caApohsRpaLhDuhthhhhpsL.ppSo.sslAtlAsKssKEtsYHh+put-hlhpLu.cGTcES+p+hQsAlsphW.ash.-hFsss-s-.................pshtttGhssssspLRppahsplsshlp.pssLslP...c.....st.hphs.G+....pG.pHo-thGhl................LschQhhpRuaPsu.sW	...................................................................................ttttp...................thcpsLhc.lhphucopllhhp.tu.p.W...hs+APsLccchsLhshs.DphGH....uh.hL.aohA.tp.......................L..........G...............tsc.Dc.lh.th...p..st.ch...+.......sl...hph..Psh.............saA.DshshsaLlDuhtlh..ssL..scoohsshAphhs+.h.hKEpsaH.RpuhchlhpLu......pGT.....c...tp...+phhQpAlschWh.sh..hFsss...-sc....................puh.s.h.th.h.t.h.s.s.cp.LRppahspssstlp...hs.LslP...s...............ss....h....phs....sc....pG.tas...G.l.................htchphhp+ua.tu.tW...................................................	0	123	282	386
+3635	PF02758	PYRIN	PAAD_DAPIN;	PAAD/DAPIN/Pyrin domain	Bateman A	anon	Bateman A	Domain	This domain is predicted to contain 6 alpha helices and to have the same fold as the Pfam:PF00531 domain.  This similarity may mean that this is a protein-protein interaction domain.	22.40	22.40	22.90	23.00	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.52	0.72	-4.28	38	767	2012-10-01 21:41:45	2003-04-07 12:59:11	11	56	60	11	298	774	1	81.90	26	11.69	CHANGED	tchhLlpsLEpLscc-hccFKthL............ptsphpIspspl-p.ss.chclAsLlhppaspctAhshslplhcchspp.cLsccLpc	........p.tLhphLEpLs..cp-hc..cFKhh.L..................ppst.tplPh....s.pl-p..As..thclAslLlppa.stptAhphslplh..cchspp.-Lscchp....................	1	23	69	115
+3636	PF00658	PABP		Poly-adenylate binding protein, unique domain	Bateman A	anon	Prosite	Family	The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (Pfam:PF00076) [1]. Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.	21.00	21.00	21.20	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.17	0.72	-4.31	38	874	2009-09-12 06:34:48	2003-04-07 12:59:11	13	31	321	31	523	833	28	70.80	49	9.26	CHANGED	tshsAuhLAsAsPpp.......QKQhLGEpLYPhI....p........phpP..-hAGKITGMLLEhDNsELLpLLEss-sLcsKVsEAlsVL	...........................hushLAsAs.Ppp...............QKQhL......GE+LaPlI....p.........................shps.....phAGKITGMLLE..h..D...s...oE....L...LphLES.s.-...uL+uKV..-EAlsVL...................	0	158	255	394
+3637	PF03068	PAD		Protein-arginine deiminase (PAD)	Mifsud W	anon	Pfam-B_2195 (release 6.4)	Family	Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognised (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen [3].	25.00	25.00	26.30	27.30	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.39	0.70	-6.04	7	323	2012-10-01 20:45:11	2003-04-07 12:59:11	10	8	86	12	176	305	2	310.40	44	60.02	CHANGED	sLsEsslFTDTVsFRlAPWIMTPNT.PP.EVYVCplpD....N-cFLcslspLspKApCKLTlCPp.ENRsDRWIQDEMEhGYIpAPHKohPVVFDSPRsRGLKDFPlK+lLGPDFGYVTRE..hsssSuLDSFGNLEVSPPVTVpGKEYPLGRILIGuS.aPpSsGRcMspsVRDFLpAQQVQAPVELaSDWLsVGHVDEFLSFVPssDpKGFRLLLASPuACapLFQEKQctGaGEAhhF-GL+tppp....oIscILuscpLpcpNtasQpCIDWNR-lLKRELGLuEuDIIDIPQLFphcptt.....AcAFFPsMVNMlVLGKaLGIPKPFGPlINGRCCLEEKVpSLLEPLGLpCTFIsDahsYHhhtGEVHCGTNVRRKPFuFKWWpMVP	................................................................................s......lapDoVhFRlAPhlhpPsh..P.plals..p..h.hp...........p........Flct..ltt.l.st...pst.hp..l...hl...s...p......s.p.s.DpW.hQD.....chEhG.Yh.....ph......P.....p....p....s....h......s....V....l....h.......c.....o.P...R.s.ttL.....p..c....F..s....h.+..plh....u.s.shG..aV.s...p.t.................t.....t...s..ssl.DS..hGNL-VSPP.lss.t.G.KpYPhGRIlhGss...hs....t.....t.u+phtpslpsFL.AQ.pVQ.sPlc.LaoDWLhVGHVDEFhsFlPs....s....s....p....KGFp...hLlASPpushcLhpctpppG......aG......cs..h..h.....F.......p.................u...lt.......t...............t.....p........................oIsplLusc..pLh..ptNtas....p...p.s...I.........chNR-lLK+ELGLs.EpDIl-.lPtLFph......p.p...............................A.....AaaPsh.VNMlV.L.....s....+.p..LG....I..PKPaGPh........l.....p..GpCsLE..pclpsLlcsLGhpCsFIDDa.sYHh.h...hGElHCGoNV.pR.pPFsa.KWWp..........................................	0	12	52	89
+3638	PF04371	PAD_porph		Porphyromonas-type peptidyl-arginine deiminase	Kerrison ND	anon	COG2957	Family	Peptidyl-arginine deiminase (PAD) enzymes catalyse the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia.  PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (Pfam:PF03068), which is a metalloenzyme.  PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologues) [1]. The predicted catalytic residues in PPAD (Swiss:Q9RQJ2) are Asp130, Asp187, His236, Asp238 and Cys351 [1]. These are absolutely conserved with the exception of Asp187 which is absent in two family members.  PPAD is also able to catalyse the deimination of free L-arginine, but has primarily peptidyl-arginine specificity.  It may have a FMN cofactor [2].	25.00	25.00	28.80	27.50	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.07	0.70	-5.39	22	1778	2012-10-01 20:45:11	2003-04-07 12:59:11	10	7	1418	31	444	1482	890	324.50	33	93.65	CHANGED	a+MPAEapPppusahsWPp+s-sW..ttthtsAptsasslAcAIu+h.........E.VplsVsssp...htsARthLss.........slcllchshsDuWhRDsGPsallssp.......G.chc..slDWpFNuWGGhh.....sappDspVupplsclpthshapss......alLEGGuIcsDGpGTlLTTcpCLLs.sRNPpLo+tpIEppL+caLusp+llWLtcGhhts...-.TsGHlDslspFlsPupVlhshs-DtsDPpYthhptshchLpshpDAcG+.hplh+lPhPs..................th.cpsG-RLsASYsNFhIsNsullhPtasDs.sDphAhclLpphFPc+clVGl.suRcllh.GGGslHCITQQ.P	................................................................hhPuEap.pptshhhW.P...p.c.....s.s...W........t......t...h..p.....sp...p...sa...s...p....lspsI.uch.........-..Vh.l.hst..ptp........htp.s.p...p.hlsp.......................plp.h.l...c..h...s..s..s..D..s..WhRDpGPhhl..hs.sp.............................u....p....ht.......slD..as..F..N.u..W..Gsph................................shc.p.D....s.p....l...s...p...p...l..s....c.....h....t....t....h..s.....h...h.pss...................hlLEG.GuI....cs.....DG..p....GTlLsTc.......pCLLs.........s....R..NPp....L................o.........+.p.p..I..Epp.LpchL...G..l.c.........+lI..WL...s.pG..h....hts....................-.....Ts..uHlDslspFl.....sssp..........llhs.......h..s.......-..D.p.......s.......D.......s.......p.......Y..t.h.hptt.h.chLppt.pcsc.....Gp.hplhcL..PhPt.......................................c...sG....c...R.L...s..A.S..YsNFh.lsN............s....u....l.l..........l........P..ta........s.........D........s.....s.........D......ph.A.hchLpphF......P.s......+....c..l.l.Gl.ss....c.pll....h.tGGslHClTQQ.P......................	0	159	301	392
+3639	PF03551	PadR		Transcriptional regulator PadR-like family	Bateman A	anon	Pfam-B_1014 (release 7.0)	Family	Members of this family are transcriptional regulators that appear to be related to the Pfam:PF01047 family. This family includes PadR Swiss:Q9EXE6 a protein that is involved in negative regulation of phenolic acid metabolism.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.38	0.72	-4.21	33	8479	2012-10-04 14:01:12	2003-04-07 12:59:11	9	19	3006	28	2200	6899	485	72.50	28	49.56	CHANGED	lLtlL.sc.psh..aGYplhpclcph..Ghhphs...cGoLYPhLc+LEccGLlssphppt..htu.sRKhYpLT-sG+ptLpc	................................lLslL..tc..pst...aGY.-.lhp..p.l....c....p....h...............s..h...h...p....h..s.........tG...olYshLp+L.pcpuh.l............p.........s....t......h.pp.............t..............tt....sR.....K...h.Y.p..lT..cpGcptLt............................................	1	832	1595	1975
+3640	PF03283	PAE		Pectinacetylesterase	Mifsud W	anon	Pfam-B_1589 (release 6.5)	Family	\N	22.90	22.90	22.90	23.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.18	0.70	-5.82	27	583	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	204	0	340	545	102	274.10	26	69.61	CHANGED	hhhhphs..hssp...................VtlsllpsAhtcGAlCLDGShPuYHhccG.GoGussWLlphEGGG.WCss......hcsChtRppT..chGSSphh.ppplsFs....GlhSspsppNPDFaNWN+VplRYCDGuSFsG.csc...spuspLaFRGp+IapAlh--Llsc.GMppAcpslL.oGCSAGGLusllaCDp....F+shLPt....sspVKCloDuGaFl...DshclsGscshcpha.....psllplps.tpslspsCss+hpPs........CFFPQpllptIcTPlFllNuAYDsWQlpphLsP.ss..tt.WttC+hs...hspCsssQlphlpsFRsphlsulpsh..tpsppsGhFlsSCasHCQotpptoWhsts..SPhlpspslAcuVGDWaasRp..hctl	...................................................................h.........................................tshC.DGo.s..ua..a..hp.u..........tu.s.p.p.all.hp.....GGu.hC.s..............hpsC........R.....ht.s...........thho...S..p......h.......p...t.h...hs......................Gllus.p.t.tNP.aas..WN.hVhl.YCsGssasG...s.......s.....p........................................................p...............t...............s..............t.........p..............h..............hapGtpl.........hp...s...lhpcLhsp.....Ghtp....A....p.........p.h..lL.sGs..SAGGhushlpsDp....hpph.hst............sspV.+sluDu..G.hFl.........................s......th..thtt..ht.h...........t.hh......t...h..p.......tt.hst.C...t.h..t.............Chas..hh......hps.Ph..Fhhp.haD.hQh.t.......................................hp..t....ph.hhptht.thht..h................u.ahsuCh.Ht...............a...................htt..........h...h..............h.................................................................................................................................................	0	128	217	285
+3641	PF03403	PAF-AH_p_II		Platelet-activating factor acetylhydrolase, isoform II	Mifsud W	anon	Pfam-B_3469 (release 6.6)	Family	Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in Pfam:PF02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.42	0.70	-6.17	7	427	2012-10-03 11:45:05	2003-04-07 12:59:11	8	13	218	13	281	1346	263	295.60	23	70.00	CHANGED	huupspsplPtssGPasVG.............CsDLMhsts....cusFlRLYYPs...p.-psp.-sLWIPpcEYh.GLu-aLss.phhGplL.phhhGShphPsphNush+ss..-K.YPLllFSHGLGAFRTlYSAlshpLASpGFlVAAVEHRDcSAusTYahc-tsssE.t.......pcpWlhh+chpt.-pEhplRpcQVpQRspEC.pALshlhpIs.tGpsscNl.....LsssFD...hppLKsslDpo+..lAVhGHSFGGATsl.......poLuc-....pcFRCuIALDsWMaPlsc-ha.Sph.QPlhFINStcFQhstslhpMKK......................hhs.ccpp+hITlcGSVHpsFsDFsFloGclIG+hhpl..KGclDsp.Ah-lss+ASLAFLQKaLsLcc-asQWssLh-G.spNl	.......................................................................................................h.............G....lG....................................t.....................t...h.....plaYPs....................t.....................ah..s...........t................s.h.......t..t..h...h...............t...h............h..h................h..................h..h....t......................h.p..h..s..s.........ss......h.............t..................st..............t.....p..aP.lllFSH.G....l..u...u.....R.ph..YSt.hshpLASp...GalVsslE...H......p.....D.tS.....us.h.o..h.h......p..............tt...................t.................................................................................................h.........t....t.................t..h....thRptQ.lp.R.....h.tE......h....shp..hl...ths....tG..p............h.........................h......t..p...........h...t.h..psp....ls.h...pp.........lshhGHSFGu.ATsh...........................................tsh.pp................p.h...p...s.....sl.hl.....Ds..a...h.......h...s......l...t.........p......t............................t.........h.................................P.............h.....h.hl.p....s..p....t...a......................t........p.............................h..p.......................................................................................................h..................t..................h.....h...h...h.....t.s.H.s.sDh..h...h......s....................................................................................................................................................................................................................................................................................	1	109	170	222
+3642	PF03985	Paf1		Paf1 	Finn RD, Wood V	anon	Pfam-B_ (release 7.3)	Family	Members of this family are components of the RNA polymerase II associated Paf1 complex.  The Paf1 complex functions during the  elongation phase of transcription in conjunction with Spt4-Spt5  and Spt16-Pob3i [1,2]. 	20.40	20.40	20.50	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.59	0.70	-5.74	12	358	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	263	0	255	360	4	334.60	24	76.57	CHANGED	p-aIs+l+YpNsLPsPshsPKhlpash....spsh.sp.hloSLhpcpphssLh...DpDLGhslDLl.........Dpchhts.s.ssp...LcscDchLL+Dsthsp.........ho+pc.ptVoaLR+TEYIS...sp.sp.t.....stcthpschthslcpshpppp..hhstpp.lctlEpTF-sspp.....phhpHssK+plpsVcshsLLPDhsphcpsahplpFsGss..........shstp-tp.........p.thpsslhtsh-hEt-caluhahs........hpppL-cphcDhp........cppc.YcaKhhR-Yshphhp...........psthp-hslhhs............pcpsssYYpPLcoRlcL++RR......lc.lVpppshsplslphRsssspEpchpcthRtch-shshsph--.E-Ec-ct.p.ppc.pcspspppptttptps.pptt...........tp.t.ctppttcptpsssotss	....................................................................................................................................................thlspl+YpNsLPs.shsPKhlphsh.......tt........phh.s....h.hh.os.Lt+p.phph.....-.-lGhslD..L.l.................s.....phh.....h..s......s...............lcPtDp.LL..c..p...h................................................psp..pt.ts.V.saLR+TpYIS..........st...s.t.t....................s.pt.php..h....thp.hp....p.t............t.....s...p.t....l.p.t...I-p..oFpsspp....................................tH.....s...+....p..lpsVphhPlhP..Dhpha.....p..s..hh.lhFsssP...............................s.t.tt.....................t.h.p...shl.h..........t..........t.........p........p....pa..h..s..h.....ah...s..............................h..t.p...h...p.....t.t-..................t...t........p..a.p.......aphhRpYph.php..................tpth.-....s.hhhh........................c.tpssaY..l..s.+hpLppcR....................t..h............p........t......s.l........lph+.t..st.t.....-...t..p.h..p.h.t.....t......................................................................................................................pttt...........................................................................................................	1	81	135	206
+3643	PF02671	PAH		Paired amphipathic helix repeat	Bateman A, Mian N	anon	Pfam-B_281 (release 5.4)	Repeat	This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene Swiss:P22579 (also known as SDI1) that is a negative regulator of the yeast HO gene [1]. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.	21.30	21.30	21.60	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.13	0.72	-4.34	121	1587	2009-01-15 18:05:59	2003-04-07 12:59:11	16	30	270	12	991	1522	9	48.30	34	10.07	CHANGED	sphYppFLclLptapp.pphstsp.................lhp................c....Vsp.Lhp.....sa..-Llp...tFsp.FLs	.................................................chYppFLcllpp.app..pp..lstst.........................Vhp................p.....Vsp..LFp.....s.as..-Llp...tFsp.FLP...............	0	344	546	754
+3644	PF00221	Lyase_aromatic	PAL;	Aromatic amino acid lyase	Finn RD, Eberhardt R	anon	Prosite	Family	This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities [1-3].	21.80	21.80	22.20	22.00	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	473	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.48	0.70	-6.05	143	3331	2009-12-15 11:53:36	2003-04-07 12:59:11	14	13	2194	102	901	2989	703	434.10	35	86.47	CHANGED	lpl.suss.Lolspltslu....p.ps...tplpLs..spuhpclppupphlp.chlpps.pslYGlsTGFGthusscI..s.........cc...htpLQcNLlhSHusGlGp............................................slspshlRshhllRlsoLu+G.....aSGlRhpllctLhph.LNpslhPhlPppGSlGASGDLAPLAHluhs.llGc.Gcs.hh.p.......Gp..................h.....hsu.s-ALppsGlpP..l.pLtsKEGLALlNGTpshoAlushulhcAppLhthAtlhuALohEAlpGsspsFcsplH.tl.RsH.GQlcsAstlRplLp.G...S......plhpscp....................+..............lQDsYoLRChPQVhGAsh-slphspcslphEhN..usoDNPLlh...........s....-...............t.s.......cl..lSGGNFHupPlAhAhDhlslAluclGslu-RRlspLlssths.G.LPsFLs......s....ss.GLsSGaMlsQhouAuLsSEN+hLApPuSsDSls.oSusp..EDHVSMushuAR+h.tchl-NlptllAlELlsAsQAl-hR........t.....shph.usshptlhphlRppVshh..p...p	..........................................................................................................................ltstpLoltplhtlh......p.....ts......spl.pls...tpuhttlptut.thlp.p..hh......t...p.s.p................s...sYGlsTGFG.thu...shpl..s..................cphtpLQ...csLlh.SHusGlGt..........................................................shspphsRhhMll+ls..o.LspG.....aSGlRhpllptlhth.lNt.slhPhlPt..pG.SlGASGDLsPL.uHhuhs.Ll.GcG...cs...hh...p...........Gc..........................hhsutcu...LpttG.l..p..P.....l.p.LtsKE..GLALlNGT.ps...ouhuhhulhcAppLhthuplhuAhohEuht.....Gp.psFc.t..p..lH.t.l.Rsa.GQ.hpsAtthRp..l..Lp.u........S.....plhppppt.............+...................................................lQD.sY....o.LRC.PQlhGush-slp...hstphlp.hEhN..u.....ssDNP....L.lh......s....c.............................................................t.s....cl..lSGGNFHu.pPlAhuhD..LtlAlAcluslu-RRhstLlssth..s.....s..LPsFLs......s.......ps..GlsSGa.M......l...sQh..ss.Auls..SEs+t.LApPuS..l.DS...hs.ouspp........ED..+VSMushAuR+h.hchl-shptllulE......hlsAsQ...ul-hR........t.....s.p.......ush.h.pps.hp.hhRphls....p...........................................................................................	0	266	520	727
+3645	PF02089	Palm_thioest		Palmitoyl protein thioesterase	Mian N, Bateman A	anon	IPR002472	Domain	\N	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.93	0.70	-5.47	2	572	2012-10-03 11:45:05	2003-04-07 12:59:11	10	11	252	6	338	538	22	229.00	32	83.50	CHANGED	DPPuP.PLVIWHGMGDSCCNPhSMGsIKKMVEKcIPGIaVLSLEIGKshhEDVENSFFLNVNsQVshVCQILtKDPKLQQGYNAhGFSQGGQFLRAVAQRCPoPPMhsLISVGGQHQGVFGLPRCPGESSHICDFIRKoLNAGAYsKhlQERLVQApYWHDPI+EslYRNaSIFLADINQERsVNESYKKNLMALKKFVMVKFhNDoIVDPVDSEWFGFYRSGQAKETIPLQESTLYTpDRLGLKtMDKAGpLVFLAhEGDHLQlScEWFhAHIIPFLc	.............................................................................PhlhhHGh..............h..Dp........sh......t.h.....p...hhp..p.....h.s.Gh...hshslpl.s.p..............s....s....tsh..hhplptQhp.ls.p.............lt.p.........L..t..p.....G...hshlGaSQ...Gu.hhRulhpps.s.....s.....s.h.....p.................shIolu.u.p......tGhhuhs..h..C................t......h.......h.C..phh....pphl.p.h.ts.Ysphs...Q...ppls..upYa+...D..P..h...c..........s......Y..h...pt...S.FLs..clN.s..E............p...................h............N..p.....s.....Y......+........c...Nh........hpLp...phVhlhF....sDshl..Php.Sp..aFG....aa.........t...ss.t..........p.p..h...........h.sh...pcp.t.lYtcDhlGL+ph.cptGpl.hh.hs...h...G...t.H...h....t.....h..s.....t...............................................	2	127	185	265
+3646	PF02569	Pantoate_ligase		Pantoate-beta-alanine ligase	Mian N, Bateman A	anon	COGs	Family	Pantoate-beta-alanine ligase, also know as pantothenate  synthase, (EC:6.3.2.1) catalyses the formation of pantothenate from pantoate and alanine [1].	20.70	20.70	20.80	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.87	0.70	-5.64	7	3517	2012-10-02 18:00:56	2003-04-07 12:59:11	10	12	3268	96	934	2614	2426	268.30	42	94.43	CHANGED	hplhpsltplpphp.+phR.p..t+plGFVPTMGhLH-GHhsLlcpA+.tcNshVVVSIFVNPsQFGssEDh-tYPRsl-cDhtlhEptsVDllFsPssc-MYPtshpsplp.tt.........Lop.LEGtsRPGHFcGVsTlVsKLFNlVpPsRAYFGpKDhQQlhllcphVpDh.hDlEllssPIVR-pDGLAhSSRNsYLssEpRKtA.uLY+uLptutphlps....GE+sspclhptht.tl....lcttpsh.lDYlEltDhp..L....-Phpp.cpt..llhVAshlGc.......sRLIDNhhl	..................................................lhpslttlc.p.hh....pp.h..+.tp.......up..pluhVPTMGsL..H-GHhsLlccA+.....p...c......s.....D...............h......V.VVSIFVNPh.QF...u.s...s.EDhspY.P...RsL.pcDhphL..........p..........p............t..................G...............V.....D............h......lFsP.s...s.c-h.....Y....P....p....s........h......p.....s...p.s...p...lss..................................lushL..-G.up..R.P.G.........HFcGV.s.TVVsKLFNl............V.....p....P......D......hAhFGcKDaQQLslI+pMVpDh..s.h.....s.....l.....c.Ilus.P.hlR.-.p..D.....GLAhSSRNsYLo.s-cR.p.tAstL..csLpt.....s..tp....th..ps......................G.p....c......s..h...pt.l..h..ptst....ph.........................Lp..p..t......h....h..plD....Ylplhcsss...L.....................p..s......h......p......p......h......p....p......t......h......ll..h.h.A.shl.Gp.....................sRLIDNh................................................	0	311	620	808
+3647	PF02548	Pantoate_transf		Ketopantoate hydroxymethyltransferase	Mian N, Bateman A	anon	COGs	Family	Ketopantoate hydroxymethyltransferase (EC:2.1.2.11) is the first enzyme in the pantothenate biosynthesis pathway.	25.90	25.90	26.10	26.10	25.70	25.40	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.44	0.70	-5.27	117	3509	2012-10-10 15:06:27	2003-04-07 12:59:11	10	8	3295	45	993	2531	3391	255.50	45	92.45	CHANGED	p..+h...TlsclpphKpp...sc+IshlTAYDhshAplh-puGlDhlLVGDSLGMVlhGhsoTlsVTl--MlaHscAVsRGsp....puhlluDhPFhSYpsoscpAlcsAs+lhc.puGApAVKLEGGt.....thsctlctLsctGIPVhuHlGLTPQslpthGGa.+lQG.+.stpsAppllcDAhuLpcAGAFulVLEslPspLAppITp..pl.slPTIGIGAGsssDGQVLVhpDhLG..l.......sshtPKFVKpYs...shsshlpp......AlppYsp-V+sssFPst-	....................hTlspLtchK...p...p...sc.....+lshlTAYDh..shA+lh-p.s.G.lDllLV.GDS.LGMllhGa-o....TLPVTl--MlaHscAV.tRG.....ut..................p....shll.uDhPFhoYt..s.o.scpAhpsAs+lh+..u.GApuVK...lEG....Gt.........tl.s-.s........lchLsptG.IPVhuHlGLTPQSV......shhG.GYKVQ...G.+.s.....tc........s......A......ppLlpDAhAl-pAGAhh...lVLEs.VPspLApcITc..tL...s.IPsI.G.IGAGs.......s.sDGQVLVhaDhLG.......l...............t...ss.....hhPKFlKpah..............shss....s.lpp..........AlppYhp-V+susFPup...................................	0	329	652	849
+3648	PF02711	Pap_E4		E4 protein	Mian N, Bateman A	anon	Pfam-B_1589 (release 5.5)	Family	This is is a family of Papillomavirus proteins, E4, coded for by  ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known [1].	20.50	20.50	22.10	23.40	19.00	17.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.81	0.72	-3.17	40	248	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	78	0	0	191	0	91.30	42	90.27	CHANGED	LpLh.ssp.....+YPLLcLLsshp...s....PPp..P.Pp..shAPp+......s+RRl.sD.............sDsssspssssssh.t..........pssWTVpTsssol..olpupTpsGToVsVTL+L	.......LpLs..sss.....+YPLLpLLsoh........T........PP+.hPsPs..PWAPp+.......+RRL.sD.............pDps.p.s.p.psssss................ps.WTVpp...t...ol..pLpApTKcGsoVlVTL+L........................	0	0	0	0
+3649	PF04755	PAP_fibrillin		PAP_fibrillin	Mifsud W	anon	Pfam-B_3698 (release 7.5)	Family	This family identifies a conserved region found in a number of plastid lipid-associated proteins (PAPs), and in a number of putative fibrillin proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.48	0.71	-4.59	12	635	2009-01-15 18:05:59	2003-04-07 12:59:11	7	13	130	0	381	643	102	170.70	22	64.03	CHANGED	tpLKppLl-ulhGp.p.RGLp.Aos-s..+scI.phlppLEuhNPossPs.-s.sLLsGpWhLhYTottslh......sLl.tspl.h.l+ltpI.QsI........Dspshsl.N.sp..htu....PhhpssholsAcFEltSspRlplpFccuhlt...l.....................h.t..t.hpssht.l........Plph.hssspspuWL.sTYLDc..-LRISRGstGslFVLh	........................................................................t......lht.h...t...h..Gh...hp........pp.......ptpl.phlpt......LE.....sh....s.ss.s......t......sh....p........s..................s.........h.LpGpWpLhY...oo..ttthh...................................h...........s.th....h......h.p.....h.s.p...lhQ.tl....................cs..ts....h...p.....h....N..hhp.........h............h.s.......h..p.s.....t........h...plp.u....p..h.p...h......h.......s.......s.......p........+.l......p.l..pFp.ps.hlt........................................................................................................................s.....h....................................t......t.s.p...u.h...h..hTY.LDc......clRls.R..us.t.Gshhlh.h..................................................................................................................................	0	148	296	349
+3650	PF04926	PAP_RNA-bind		Poly(A) polymerase predicted RNA binding domain	Wood V, Bateman A	anon	Pfam-B_1341 (release 7.6)	Domain	Based on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding [1].	22.10	22.10	22.30	22.20	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.84	0.71	-4.70	54	630	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	301	11	392	595	5	146.80	29	22.62	CHANGED	sFFpp.YKaYLplhsuupsp-.pphcWpGhVESKlRhLlt........pLEphss.ltlA.HPaP+sFp.......................................................................t...ppppp............................haposaaIGLphpttps.pttp................lDlphsspcFhshsps....h.t..h.tsthplpl..paVKpppLPs.V..atputp+sp+s	.............................................................................sFFpp.YKaYlhlhs..s......us......s......p-..pthpWs.GhVES+lRhL.lt........pLE.+.s.ph...ltl.A..Hs.PpsFs.........................................................................................................................................psppp.....................................apohaa.lGLthcp...s....t.s.t....t.............................p..lDlshsl.ppFpsp.lhp....h.p...hh.ctsh.plts..pHV.+.pppL.phl....th.pc....t..................................................................	0	121	204	312
+3651	PF04795	PAPA-1		PAPA-1-like conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6501 (release 7.5)	Family	Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein. 	21.00	21.00	21.90	21.90	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.12	0.72	-3.28	19	276	2009-09-11 14:54:57	2003-04-07 12:59:11	7	9	209	0	180	273	0	83.40	31	21.17	CHANGED	Etth+RAEtARRR+.QuEK+sEEpKh-TIp+LL+ppu.......tt+.tt...tttppshtppcstcsppsssshlRals..utpGopluhPpc.lssP	.................Ehth+RuEtAR+R+..uEK+sEEc.........K.......t-TIp+LLKppu.............tp.p.t.t..p......t.t.t.....pp.....tttpt..c.ttp.tt.ssshlRalp....s..pGshlshP.t.h...........................................................	0	50	95	142
+3652	PF03333	PapB		Adhesin biosynthesis transcription regulatory protein	Mifsud W	anon	Pfam-B_3068 (release 6.5)	Family	This family includes PapB, DaaA, FanA, FanB, and AfaA.	20.40	20.40	20.40	23.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.00	0.72	-4.17	14	275	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	191	2	10	111	1	87.40	42	78.55	CHANGED	hpphst......hhhph+pthLhPGplsEc+FaLLhEISsI+ScKVI.AL+DYLVhGhoRKElCE+asVssGYhShuLsRLp+lsphVtpls.aY	.................t.th...............h+tutL.PGplsEEpFaLLl-ISsI+S-KlIhAL+DYLVpGaSRKpVCE+ashssGYFSsslsRLpclsphVtpLssaY...........	0	1	3	6
+3653	PF03628	PapG_C		PapG chaperone-binding domain 	Finn RD	anon	Pfam-B_3074 (release 7.0)	Domain	PapG, the adhesin of the P-pili, is situated at the tip and  is only a minor component of the whole pilus structure.  A two-domain structure has been postulated for PapG; a carbohydrate  binding N-terminus and chaperone binding C-terminus (this domain). The chaperone-binding domain is highly conserved, and is essential  for the correct assembly of the pili structure when aided by the  chaperone molecule PapD [1,2]. 	19.60	19.60	20.70	19.80	19.00	18.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-10.42	0.72	-4.38	3	75	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	38	2	1	61	0	108.50	73	33.56	CHANGED	HGNLSIDSANGNYASQTLSIYCDVPVoVKISLLSNTpPAYNN.QpFSVGLGNGWDSIISLDGV-puEETLRWYTAGS+TVTIGSRLYGEuGKIpPGsLSGSMTMlMpLP	........HGDLSINSANNHYA..AQTLSVSCDVPsNI.RFhLLpNTsPsYSH.GppFSVGLGH...GWDSIVSlNGVDTGETT.M..RWY+AGTQNLTIGSRLYGESSKIQPGVLSGSATLLMILP....	2	0	0	0
+3654	PF03627	PapG_N		PapG carbohydrate binding domain	Finn RD	anon	Pfam-B_3074 (release 7.0)	Domain	PapG, the adhesin of the P-pili, is situated at the tip and is only a minor component of the whole pilus structure.  A two-domain structure has been postulated for PapG; a carbohydrate binding N-terminus (this domain) and chaperone binding C-terminus. The carbohydrate-binding domain interacts with the receptor glycan [1,2].	25.00	25.00	48.80	48.10	22.10	21.10	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.50	0.70	-4.90	4	66	2012-10-02 17:35:21	2003-04-07 12:59:11	8	2	29	4	1	50	0	216.30	62	66.66	CHANGED	MKKWFPAFLF.LSLSGsNDALAuWpNlMFYuFNDh.shsuGNVplhDpsQFhlsWpoGuATAT..YsuCsGPEFssG..lYapEYlAWlVVPK+V.TpsGYslFl-VpSKhGWS.ENpsDpD.YaFhpGYcWDphsssuuRlCh.sGpp+pLsppFs-lhFplhLPsDLPKGcYshPl+YlRGIQ+HaYsahts+YKhPYs.hKpLPtsNTl.hShcNsGuCRPSAQSLEI	..MKKWFPAhLF.LslSGpssA...hpshhFYShsDs..h.thsVhlTphsQFIsshpsu.uTsT..aspCNG.sascG..hYapEYhAWlVhPK+V.ohNGYslalElpsKGSaS.-sp.DNDsYahhKGatWDE.A.suGplC.p.GEpppLs.p.FsslhhpstLPsDLPhGDYohsl.ahpGhQRp.hsYlGuRaKIP.slhKThPhpsph.F.hKNhGGCRPSAQSLEI	0	0	0	0
+3655	PF03025	Papilloma_E5		Papillomavirus E5	Bateman A	anon	Pfam-B_1916 (release 6.4)	Family	The E5 protein from papillomaviruses is about 80 amino acids long.  The proteins are contain three regions that are predicted to be transmembrane alpha helices.  The function of this protein is unknown.	25.00	25.00	37.90	37.60	21.10	19.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.91	0.72	-4.03	13	139	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	32	0	0	103	0	70.20	58	92.77	CHANGED	llhlFllCFCVhLhlChhl.PLL.SlplaAhlllLVllhW.VshTSPhcsFhVYllFhYlPhaLlHhHA.hhhp	.....LLssFLLCFCVLLCVCLLlRPLLLSVSsYsoLlLLVLLLW.losuSshRsFhVYllFlYIPLFLIHsas.......	0	0	0	0
+3656	PF02380	Papo_T_antigen		T-antigen specific domain	Mian N, Bateman A	anon	Pfam-B_1131 (release 5.2)	Family	This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.	19.10	19.10	20.20	19.80	18.30	17.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.92	0.72	-4.06	10	268	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	63	6	0	201	0	85.00	40	54.97	CHANGED	V.ussasssh-phaCKpWssCh+shs.spCs.CllChL+ppHcp+.KhhR+sPLVWl-CYCa-CappWFGh-loppslhhWspIIupTPhcsLcL	.......................l..t.h....cphasKpWshC.pp.p.scCs.ChhC.LchpHhp+.KhhRKp...PLVWl-CYChcCappWFGhsl.TpE.ohpaW.plltpTsa.p.LcL..................	1	0	0	0
+3657	PF01507	PAPS_reduct		Phosphoadenosine phosphosulfate reductase family	Bashton M, Bateman A	anon	Pfam-B_590 (release 4.0)	Family	This domain is found in phosphoadenosine phosphosulfate (PAPS) reductase enzymes or PAPS sulfotransferase. PAPS reductase is part of the adenine  nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases [1]. The enzyme uses thioredoxin as an electron  donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) [1,2]. It is also found in NodP nodulation protein P from Rhizobium which has ATP sulfurylase activity (sulfate adenylate transferase) [3].   	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.14	0.71	-4.44	27	7027	2012-10-02 18:00:56	2003-04-07 12:59:11	14	43	3053	30	1986	5609	1987	185.10	24	61.61	CHANGED	phshsaShGp-usVhLcLshKshhs..h....................P.llalDTGacF.Eshcah-cltc+h...sls.lhlhtstcshtpths.hs...phapp........hs.lhKscslpp........................................ALcch..p..AhhsGhRRs-st.sRuphtlhphcss.t.......................hl+lh.PlhsWott-lWpYlhtpslPhssLatpG.....................................apolGCh.sTss	..................................................................................................................t..sh.hS.h.G.t-us....V.hL.c....L....s.t..ch..hhs....h.....................................................s..ll..a.l....D..T......s......h......p.........F...........E.s........h........p.....a.......h.........-...............c.....h.........t...cph..............sh.....p....l....h......s....h....p....s............t......s...h..t.....t..t..h......s.........h........t..................t..h.app......................................................h.h.K..sp.s....hpp........................................................................................................................sl....p.....ph..........t...t..u..h...h..sG...h.RR.--s.......t...s.......R.........u........p.........................h.....h..s..h....c..p..t......tt.....................................h.+.....lh..Pl..h...s...W...o..ptDlWpYl...tp.......p.......sl.............h........ss.La...t.t........................................................a..ho...lGsh.hTt...........................................................................................................................................................	0	598	1228	1656
+3659	PF03285	Paralemmin		Paralemmin	Mifsud W	anon	Pfam-B_4064 (release 6.5)	Family	\N	25.00	25.00	25.40	26.60	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.94	0.70	-4.92	6	266	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	38	0	120	211	0	209.00	26	60.43	CHANGED	h+KQMQEDEtKTRtLEETItRLE+ElEpLEsGsSs.suoKEs.stsu........sPAtpE.p.csl.ssppoPLsTs.ttpchS.oPh+.stussMMpA............................................VVHAV...DGsspNGlpsLSSSEVDELlHKADEVTLuEuutsu...-............sss.s.t+sTP.R+EITGVpA+PtpssstssstpPutEsPVTMlFMGYQNVEDEsETKKVLGlE-.TIKAELVVIEDu-spstsps.....+-pAPPNGSAuEPstsssptEEsphs..ssssssssc....DhshKKQRCKCCoVM	..................................................................................................................................................tp.ppDp.php.LEpsl...R..L..EpE.lp.LEp.t.t.t..hu.spEp..h..t..........................hpc.....c...p............................................................................................................................................................................................................................................................................................................................................................p.PVTMlFMGYQph.-D.pt.Et.pp.hh.uhpt...hlpAElVlIp-ttt....................................................................................................................................................................................................	0	4	21	51
+3660	PF01508	Paramecium_SA		Paramecium surface antigen domain	Bateman A	anon	Bateman A	Domain	This domain is a cysteine rich extracellular repeat found in surface antigens of Paramecium.  The domain contains 8 cysteine residues. 	21.20	21.20	21.60	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.79	0.72	-3.76	78	1822	2009-01-15 18:05:59	2003-04-07 12:59:11	11	40	5	0	1522	1826	0	63.40	27	47.23	CHANGED	ttTcspCpua.ss....CTs.t..........sG......suClsh...ssCssY.sspssCtps.............ssspChWsss........tsChsto.......Cs	....................h..ocspC.psah..ss............Cos..................sG.......suCl..ph....ssCssa...tspp..s..Chts................ssstChWsss............tpChs.ts......Ct..........................	0	1522	1522	1522
+3661	PF03210	Paramyx_P_V_C	Paramyx_P_V;	Paramyxovirus P/V phosphoprotein C-terminal	Mifsud W	anon	Pfam-B_2037 (release 6.5)	Family	Paramyxoviridae P genes are able to generate more than one product, using alternative reading frames and RNA editing. The P gene encodes the structural phosphoprotein P. In addition, it encodes several non-structural proteins present in the infected cell but not in the virus particle. This family includes phosphoprotein P and the non-structural phosphoprotein V from different paramyxoviruses.  Phosphoprotein P is essential for the activity of the RNA polymerase complex which it forms with another subunit, L Pfam:PF00946. Although all the catalytic activities of the polymerase are associated with the L subunit, its function requires specific interactions with phosphoprotein P [2]. The P and V phosphoproteins are amino co-terminal, but diverge at their C-termini. This difference is generated by an RNA-editing mechanism in which one or two non-templated G residues are inserted into P-gene-derived mRNA. In measles virus and Sendai virus, one G residue is inserted and the edited transcript encodes the V protein. In mumps, simian virus type 5 and Newcastle disease virus, two G residues are inserted, and the edited transcript codes for the P protein [2]. Being phosphoproteins, both P and V are rich in serine and threonine residues over their whole lengths. In addition, the V proteins are rich in cysteine residues at the C-termini [3]. This C-terminal region of the P phosphoprotein is likely to be the nucleocapsid-binding domain, and is found to be intrinsically disordered and thus liable to induced folding [5].	25.00	25.00	38.50	64.70	23.40	19.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.64	0.71	-4.35	21	673	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	103	5	0	640	0	161.50	42	37.80	CHANGED	sclcpchcpILsplsol.tlKs-lpsIKs.......olATlEGploolpIh-PGsusss..sssclctssc.pPllssssGcssspltc........................psplthD.Lu+Plsspsppshthssssssho..+..pslpuLIcsphhsscp+pchhphlsps+opp-Ltcl++tIl	.......Klcpp.phllpphsSl.hh+uElpplKp.......SlushEupLu.hhIh.PGhupss..shuDlc..tssc.+PllspssGcs.s...Vhp........................tGplhhshh.pPls+.s.p.hhshs..ss..s..s.shu..+..sslRulIpSp.hc.sppthLhohLDshcuhp-ltKh+ph................................	0	0	0	0
+3662	PF00946	Mononeg_RNA_pol	Paramyx_RNA_pol;	Mononegavirales RNA dependent RNA polymerase 	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_586 (release 3.0)	Family	Members of the Mononegavirales including the Paramyxoviridae, like other non-segmented negative strand RNA viruses, have an RNA-dependent RNA polymerase composed of two subunits, a large protein L and a phosphoprotein P.\	  This is a protein family of the L protein. The L protein confers the RNA polymerase activity on the complex. The P protein acts as a transcription factor [2].	20.60	20.60	24.20	24.20	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	1072	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.82	0.70	-13.58	0.70	-7.19	41	1469	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	433	0	4	1221	0	621.10	23	54.24	CHANGED	EsHLsSPllppclhhhlp.hsshspshthcsps.h.t.hc..hphhtt.psphhtchtph.pshltpplhsh...........ththl.asph...Lh...ph...phspphpphh+hs..spshshhsptlpphhp.....plshpLsspsphtppttt..hp.................phhplt........................................thht.spahp.h.hWh.h...............chph+pllpphpptppppppshlh..hcspshhlllsspllhlhspp.th..hhhhTa-hlLMhsDllpGRhps.hhsshs.......sphssht.pl...........ppLaplsDpl..hthhGsssYsllshlEslshuhL.QLt-.hh.Lp...GpFhsahhsEltp...tLptpshhsptt...hhp.....................lhslhp.phshc.huElauhaRpaGHPhlc....utpAhcKVRcphstsK..llshpshhcstuhFpthlIsGahcc+st.........................tWPssphshpssp.lpphhcssptloh.phslcpacpastlpFppth-hshspDLohahKDKAlSss+p-Whosa.cp.h............h.....psstsstoRRLl.sFLp-ssFsshphlpYVhstpYLpDs-aslSholKE+ElK.sGRhFAKMoa+hRtsQVluEsLlAspluchF+-ssMstsphcLpKpLhphSp.u..................................................................................................................psscshchsushloTDLpKaChsaRaposshauppLsclaGhssLFpWlHhhlpcSslYluDsasPPpsssp.hsL-psss.........sslhhpsshGGIEGhCQKhWTlloIshlhLsAhcsss+ltullQGDNQsIslTpcV......shshppccptshptsppahptL+pshtslGHpLKtpETllSucahlYSKplaacGhlLspuLKshoRsshhosslh-sspuusSsluTshtchtEpGhshhhuahlshhhshpplhh..........pl....................hashssshspslpphhh.....................ps.shlhth...sllPupLGGl.sahshoRlahRslGDPlTsulAclKch...............Ipsshhsppllphlhs.ppPup.....usahcLssDPaSlNlststssTshLKphspcslhps..osNshlpulapcssppE-cpLupFLhspcslhPRsA+tIhspo.sGtpcpIhGhlDoT+Tlhptshpppslssphlpplhphshpphphhhphhpp	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lp.......uh..................................hs.hh..hh..hhpp.t...........................a..................................................hh.h...tt.....t.h...h......h..h.h...h.h....s.p.hhpDKuhs..pp.h.t.h...........................t......sp+l.l..hltp..hs.....p.h..h.p...thh....p...ph.huhp.KE+Elp...GRh....sh..R.h.hhsE.hltp.hh.hh.t.hhh.s..p..c.h...s.........................................................................................................................t.....t.h....hDhpKas.t.Rhp....hhp.hhsphhGh.phaphhH.hh..shhhhs...s.....t.....h.t....p.........t.h.hh.....GGlE.G.hpQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	2	4
+3663	PF01692	Paramyxo_C		Paramyxovirus non-structural protein c	Bashton M, Bateman A	anon	Pfam-B_1202 (release 4.1)	Family	This family consist of the C proteins (C', C, Y1, Y2)  found in Paramyxovirinae; human parainfluenza, and sendai virus. The C proteins effect viral RNA synthesis having both a positive and negative effect during the course of infection [1]. Paramyxovirus have a negative strand ssRNA genome of 15.3kb  form which six mRNAs are transcribed, five of these are monocistronic.\	  The P/C mRNA is polycistronic and has two overlapping open reading  frames P and C, C encodes the nested C proteins C', C, Y1 and Y2 [2].	25.00	25.00	180.00	179.80	22.20	21.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.42	0.71	-4.70	4	36	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	19	0	0	53	0	194.90	70	97.69	CHANGED	M.phlKuhl.LtcRcQEspphophpssoShsSY..SsPTsc+TctsohpSopts+coA...cPolstKscQQ+pt.KIlDQlp+l-SLGcpss.pQ+phlEhLIpKlYptsLGEEhsQhl.LRlWuhEEoPEuspILpMc.chRc.llpMKhERWlRTLlRGKpspL+.FQpRYpEVhPYL.ppKVEpVIMEEAWsLusHllQ-	.M.phl+thl..ttRcpEppphopM.SDS.hpSY.sst.psEcTEAGShssSTh.Kcpuh.hcPplpsKpcpp+RRPKIIDQVRRVESLGEQsSQ+Q+HMLEoLINKlYTGPLGEELVQTLYLRIWAMEETPEShKILQMREDIRDQlL+MKTERWLRTLIRGcKTKL+DFQKRYEEVHPYLMhE+VEQlIMEEAWpLAAHIVQE	0	0	0	0
+3664	PF00973	Paramyxo_ncap	Paramyx_ncap;	Paramyxovirus nucleocapsid protein	Finn RD, Bateman A	anon	Pfam-B_158 (release 3.0)	Family	The nucleocapsid protein is referred to as NP.  NP is is the major structural component of the nucleocapsid. The protein is approx. 58 kDa. 2600 NP molecules go to tightly encapsidate the RNA. NP interacts with several other viral encoded proteins, all of which are involved in controlling replication. {NP-NP, NP-P, NP-(PL), and NP-V}[1,2,3].	21.40	21.40	23.40	23.20	20.60	21.30	hmmbuild  -o /dev/null HMM SEED	524	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.76	0.70	-5.80	9	5874	2012-10-01 19:59:50	2003-04-07 12:59:11	14	1	449	4	0	2227	0	180.70	74	97.00	CHANGED	MAoLLKSLALFKRNKDKPPLAuGSGGAIRGIKHVIIVPIPGDSSIsTRSRLLDRLVRhlGDPDISGPKLTGsLISILSLFVESPGQLIQRITDDPDlSI+LVEVlQS-pSQSGLTFASRGssMDDEADcYFoh--Psuu-ppphtWFEN+EI.DIEVQDPEtFNMlLAoILAQIWILLAKAVTAPDTAADSELRRWlKYTQQRRVlGEFRL-KtWLDsVRNRIAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFGIETMYPALGLHEFAGELSTIESLMNLYQQMGEsAPYMVILENSIQNKFSAGuYPLLWSYAMGVGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSsLAuELGITtEEA+LVSEIAupTs-DRssRuoGPKQuQVSFL+sDpu-stp.psut+--t+shQs+tctppu.+ss+hscsoDppsso.sscThlDlDpspEuspDP.ss++SAEALh+hpAMApILccsshssDoshsYND+DLL	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVSSTLASELG.ITA.E.D.A....R....LV.S.EI...A....M.H.T..T...ED.R.hSR.A..VGPRQ........AQ..VS.....FL..H..G..DQSEN..EL.P..GLG.G.KE...D...RRV..KQ.SRGEA......RESaRETGs.S.R.ASDARAAHLPTuTPLDIDTASE.uQDPQDSRRSADALLRLQAMAGILEEQGSDTDTPRVYNDRDLL.................................................................................................................................	0	0	0	0
+3665	PF02725	Paramyxo_NS_C		Non-structural protein C	Bashton M, Bateman A	anon	Pfam-B_1636 (release 5.5)	Family	This family consists of the polymerase accessory protein C from members of the paramyxoviridae.	20.60	20.60	20.70	21.80	19.10	20.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.82	0.71	-4.62	6	123	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	31	0	0	111	0	164.30	72	90.13	CHANGED	pPSc.l..shhph++shpuGp+PssppctpcssssR.+coLRISsNHApQQhDQs+oAphhphIRDLE+ulssLh+hsss.cpspcpsLpYsVIMFMITAVKRLRESKMLTlSWFpQAL.llssSpEEpcsLppAMhILAplIP+EhL.LTGDLLPuLppp-.LM	.........................................................G.LSRPSPSAHWPSRKsWQHGQKYQTTQDRoEPPAcKRRQAVRVSANHASQQLDQLKAVHLASAVRDLERAMTTLKhWESPQEISRHQALGYSVIMFMITAVKRLRESKMLTLSWFNQALMVIAPSpEETMNLKTAMWILANLIPRDMLSLTGDLLPSLWGSGLLM.......	0	0	0	0
+3666	PF01806	Paramyxo_P		Paramyxovirinae P phosphoprotein C-terminal region	Bashton M, Bateman A, Coggill P	anon	Pfam-B_1628 (release 4.1), Karlin D	Domain	The subfamily Paramyxovirinae of the family Paramyxoviridae now contains as main genera the Rubulaviruses, avulaviruses, respiroviruses, Henipavirus-es and morbilliviruses.  Protein P is the best characterised, structurally of the replicative complex of N, P and L proteins and consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT [1]. The P protein is an essential part of the viral RNA polymerase complex formed from the P and L proteins [1]. P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional.The C-terminal part of P (PCT) is only functional as an oligomer and forms with L the polymerase complex. PNT is poorly conserved and unstructured in solution while PCT contains the oligomerisation domain (PMD) that folds as a homotetrameric coiled coil (40) containing the L binding region and a C-terminal partially folded domain, PX (residues 474 to 568), identified as the nucleocapsid binding site. Interestingly, PX is also expressed as an independent polypeptide in infected cells. PX has a C-subdomain (residues 516 to 568) that consists of three {alpha}-helices arranged in an antiparallel triple-helical bundle linked to an unfolded flexible N-subdomain (residues 474 to 515).	25.00	25.00	164.00	163.80	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.64	0.70	-5.12	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	20	2	0	49	0	240.10	59	42.99	CHANGED	EESToSs-EMATLLsSLGVIQSApEFELSRDASaVFA+RsLKSANYAEMTFNLCGLlISVEKSp-sKV-EN+sLLKQIQE-lcShRDlHKRFSEYQKEQNSLlMSNLSTLHIITDRGGKTDsP-soTRSPSVFTKuKENKlKKTRFDPSMETLGspKaKPDLIREDEhRDEI+NPVhpEpNs-scASNASRLlPS+EKsTMHSL+LVIENSPLSRsEKpAYIKSLpKCKTDQEVKsVMELFEEDI-SL	..tESsp.hcchhTLLpsLGVIQSspch-..pDtphVhstpsLpsAshAphh..lsGLllusphspssKlsp.pp.lhplppslcphc-.a+Rh.E.QKEQ.SLlhS.lSsL+IhT-RGGKpDps-ossRos.lhsKsKEpKhKtTRFDP.MET.G..K.hPDLhRcsEhpsE.cs.VhpEhsopsctSNAoRLlPp+ppsTM+SLhlVIpsSsLSpupKtuYIppLp+CKoDpEVpplM-hhpEDlpS...	0	0	0	0
+3667	PF01279	Parathyroid		Parathyroid hormone family	Finn RD, Bateman A	anon	Prosite	Family	\N	19.70	19.70	20.90	20.00	19.40	19.30	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.49	0.72	-3.37	11	168	2009-09-12 04:59:12	2003-04-07 12:59:11	12	2	66	21	66	160	0	89.80	41	64.87	CHANGED	pKRSVSctQLMHD+G+sLp-hcRRhWLQcLLc-VHTAphht................................shstsu.p.KPsssTKNlP.tatL.-pEup..sLsQETpKs.saK-....p.hcs.shKKKsKs	........KRuVSEhQLMHD+GKslQshcRphWL+chlp-lHTAphc.................................sss..csussp+Pt..tppcNh................-sc...t+.....Lspt.sKs...............................................................................	0	3	8	27
+3668	PF02195	ParBc		ParB-like nuclease domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.10	0.72	-3.88	51	10329	2012-10-01 20:12:50	2003-04-07 12:59:11	13	78	4621	22	2371	7819	3243	91.10	27	28.42	CHANGED	hplslsplp....sppps+........tpplccLhpoIcp..................pGhh.pPllVcppt.....shapllsGcRRhcAsphhG......hpcl.....ssllhphs........cppththslh-Nh	..........................................................................h..lslsplt.....ss.h.pPRph...........spppl.p-.L.s.pSIcp......................................pG.ll...p.....Pl..lVcptt...........................stYpl..l..s.G.c.R..R.h.+......A.s.p.h.hu.........................hppl.......P..s..l.l.t.phs........cpph.h.t.h.slhcN............................................................	0	734	1530	2000
+3669	PF00644	PARP		Poly(ADP-ribose) polymerase catalytic domain	Bateman A, Griffiths-Jones SR	anon	Bateman A	Family	Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a  carboxyl 40 kDa fragment is still catalytically active [2].	23.90	23.90	23.90	24.00	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.32	0.70	-4.90	28	1951	2012-10-01 23:25:29	2003-04-07 12:59:11	15	267	268	92	1317	1843	56	176.60	20	23.35	CHANGED	Lps.plpsLcpsScEaphlppYhpsTtsss+t.....shplhclF+lpRpuEtccFpttcp.......hcN..............+hLLWHGSRloNasuILspGL+ls.spuPlsGhh.....FGKGlYFADhsScSA..pYshs..sts.......ss.....suh......hlLu-VALG-.h.clhtsp..h..pp...shpSstGhGcstP......tt......ps.....lPtucs.hssthpsst...l..sEYlVYcssQl+h+YLlclph	............................................................................................................h..tp.pat.............l.p.h.p....s.h.t......................thp...l......p....l....c.....l....p...p.......t.........pp..apt.tpp..........................................hs.................................cphLaHG.o...p.h....p.........s..h.................t..u..Il...p...p..Gh....................s..............h..s....s...h.p.....G..t..h............................aGp..G.l.YF..A..s..p...s..o..h.Ss...........p..Ysts......ts................................ps.......th........................................hh..lsc.VhlGp..................................................hh.u....t.............................................................................................................t.alla.p....t...ph..tall.h..h.................................................................................................................	0	534	710	997
+3670	PF02877	PARP_reg		Poly(ADP-ribose) polymerase, regulatory domain	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a  carboxyl 40 kDa fragment is still catalytically active [2].	26.80	26.80	26.90	27.00	25.50	26.70	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.57	0.71	-4.49	35	515	2009-01-15 18:05:59	2003-04-07 12:59:11	9	63	207	33	360	542	8	135.40	33	17.01	CHANGED	cScLstpVQ-LlpLIFDhctMppsMtEhpaDscKhPLGKLSpcpIppGYplL+clpchlp...............tssppstl.c......LSNcFYThIPHsFG...hp+PP..llcotchlKpKlchLEuLp-I-lAspllcsspssc....hssLDppYc	..........................................................spLs.tlpcLlphIash..ch...h...c..psM.h...c.h.................p.hD.h.p....K..hPLG.KLS+ppI.ppGapsL...pclpphlp................................................ts.s.pp.ppl.-...........lSscFYTlIP.H.s..F.G....h.pp.PP.....lIss................ctlp........p.K.l.c.hL.......-sLt.DIElA.pLlpsspp..sp.........cPlDtpYp...............................................	0	142	203	291
+3671	PF01358	PARP_regulatory		Poly A polymerase regulatory subunit	Bateman A	anon	SCOP	Domain	\N	24.00	24.00	24.50	25.00	23.70	23.90	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.90	0.70	-5.77	6	111	2012-10-10 17:06:42	2003-04-07 12:59:11	13	2	69	24	18	112	3	256.90	44	70.01	CHANGED	huhcKP.hhYFcEIssEh-YcsEstsph..pKhPhQGQLKLLlGELaFLs..pLp++shLsu.sslVYIGSAPGsHIpaLh-aapshsl.IKWhLlDGRsHDspLpuLps....Volls+FVDEcYlpph+pt..hph.+llLISDIRSpRG..pEPoTcDLLpDYuLQN.MlSlLKPlASSLKWRCPFPDQW...I+-FYlPcGpEhLQPFAPsaSAEMRLLSlaousshpLpsloppcuhpYEKKMaYLNphlR.+IllsFDYsNQcYDaFaMa+hL+Tlhhs..KoFsosKsKVlalppSIF+hLsI	.........................h.thpcP..hhahp-lstth-Ycscsspp...h.....KKhs..apGQhKLLLuELhFLo......+LpR+..Gh...Ls......u......ssVVYlGSAPGoHIpaL......c.-hF.shs..l+WhLIDsRpHDs.h.LpuLcs......VoLls+Fs.sEp...hl+..pl+cp..hp..tcIlLISDlRStc..s.......ssEP..s.T...tD....L...L.p...sYsLQNhh..lplLpPhAS.LKaRsPFP...DpW.............hccah..lscGschLQsFAPphSuEhRLlslhss.pshp.hppls.p.DshpYE++MaYhNpllR.phl...lsFDYsspp..Y.DaaahahhL....ps.lh.s..p.a..s.ptpll.hppthFp.lt.................................................	0	14	16	18
+3672	PF00740	Parvo_coat		Parvovirus coat protein VP2	Bateman A, Finn RD	anon	Pfam-B_436 (release 2.1) & Pfam-B_445 (release 3.0)	Family	This protein, together with VP1 forms a capsomer. Both of these proteins are formed from the same transcript using alternative splicing.\	\	    As a result, VP1 and VP2 differ only in the N-terminal region of VP1.\	   VP2 is involved in packaging the viral DNA.	19.80	19.80	20.00	20.00	18.20	19.70	hmmbuild  -o /dev/null HMM SEED	529	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-13.16	0.70	-5.55	24	3412	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	190	158	0	2269	0	301.20	29	80.82	CHANGED	G.......suGuGuuGVGsuoGsWcssopapt.....spVospsTRphhLsh.ssc...Ypplp..ssspos.............sssahshsTPWuYhDhNtassaFSPpDWQpLlNshtph+PcuhphcIFNl.lKpVTp....sss.ssshsNsLTuslplhsDssapLPYs.ussppsshs.aPhcsahlsQYuYh.....................sohssssss...p.scc........osFasLEpt.shphLRTGspFph.oYpFp.shPh+psasappshphhhNPlhpphhhthsshsssss.st......hppsptss..httpspNalsG............Pt.....h.ppshpsssusshpsshs....................ts.tthssppsshsst.shspptspssstt......hppphtass.s.puscssp.thspphshscptht.....t..t.p.hh.......hssss.uspos.ph...........sslhshhhhsuulWpscslYhpG.IWsKhPcsDt+h+hp.sthGshshppPPsQlFlKhsPsPss...p..ss.usssShIspYuThphpsclpaclc.+csoppWNP.hQhohss.......s.tshlsas	.................................................................................................tt......G...spu.a.tts.h.........lhsp.oR..hh....tc...Y+.....s...................p..hth.TPWthhshNtht.aFsP.-aQhlhpph.tht..thp.pl.tl.l..Kpl.p.....t.................................................................................................................................................................................................................................................................................................................................................................................................................................ss.pss.ph...............ph.h..stl.s..slh.ps.lWsK..phD.p.hhp.s..s.hs.ppsPsplFlKhh...ss.......t..s.....ohls.Yssh.hpsph.acht..h.totpWpP..p.s.............................................	0	0	0	0
+3673	PF01057	Parvo_NS1		Parvovirus non-structural protein NS1	Finn RD, Bateman A	anon	Pfam-B_400 (release 3.0)	Family	This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA [2]. NS1, is the major non-structural protein.  It is essential for DNA replication.  It is an 83-kDa nuclear phosphoprotein.  It has DNA helicase and ATPase activity [1].  	20.00	18.00	20.00	18.20	19.90	17.90	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.45	0.70	-5.53	24	1228	2012-10-05 12:31:08	2003-04-07 12:59:11	12	11	210	5	11	1432	7	174.20	34	51.93	CHANGED	p......................spspcca..............hsLlchLl........ccGlsoEcpWhths..ppYhphpssssutpplcsuLphsppchssstsshcalsptsss............hshppN+lhplhphpGYsPhhsGphlhsWhs+phGKRNTlWha.........................GPusTGKoplAp...................AIApslPhaGsV..NWsNcNFPFsDsss+hll.WW-EGhhpsphVEssKulLGGpsl+VD.....pKs+sosplpsTPVllTSNs-hshV.hsGsssohtHtps............Lc-RMhphphscplsss....aGhlopp-l+pah.pWupp.........thphshphh	.....................................................................................................................................................................................................................................................................................................................................................................................................hh...........................hlst....h.......h.G..hl....Nh..N.....s..FsF..s...D...st...t.+...ll.haE.E..s..h..h..p...p..s...hV...E..s..uKsILG.Gp.tsRlD......Kt+sS.h..l..sPVlI.o..oNtD..l....h.l.ssGssso..Htts............lppRhh.hph......h..s.....hs.h.....h..hh.........................h.................................................................	1	9	9	10
+3674	PF00989	PAS		PAS fold	Bateman A	anon	Sequences from SMART alignment	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.22	0.71	-10.01	0.71	-4.29	49	15580	2012-10-04 01:10:46	2003-04-07 12:59:11	19	1711	3946	104	4551	43707	3363	102.20	15	16.49	CHANGED	pchptllcs...hssslhshD..tsGtlhhhNsshpplhGhst..pchhGpslhphl.ttp.......hhptltphhtstpptpshphphth..........puphhhhplpssshhstssp...shhshhpDl	.............................................t..hptllps.........hs..s..s..l....l...s....l......-.......pp.....G.......p..........l..........h...h....h..Ns.s....s.p....p....l......h.....G.....h.......st.......p..-........h..........h.......G.......p.......s.........l....h....p.....h.......l.............................................hh...p..h..h....t.......p......h.....h..........t......t......p......................t...........p...h...h.....................................t.......h.....h.........hp..h........h..........................................................................................................................................	0	1473	2845	3740
+3675	PF03793	PASTA		PASTA domain	Yeats C	anon	Yeats C	Domain	This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases [1]. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.77	0.72	-4.32	237	11616	2009-01-15 18:05:59	2003-04-07 12:59:11	14	55	2312	34	2319	8832	1936	62.10	23	21.30	CHANGED	splP.slhG....hshpcApp.hLpp.......tGl........................ssshspGp...VlpQsPss.....Gspl.pp..us.plplhlup	..................tlP..s.l.hG............hshppApp..tLpp.........tGl...........ht..t................ssphs.pGp.......V........l.....p.......Q.....s.P.s.s.........Gsp..l..pp....ss..plplhlu..................................	0	910	1702	2086
+3676	PF00292	PAX		'Paired box' domain	Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.47	0.71	-4.42	6	1629	2012-10-04 14:01:12	2003-04-07 12:59:11	13	23	304	7	623	1527	5	115.90	67	31.76	CHANGED	GpGcVNQLGGVFlNGRPLPNpIRp+IVEhAppGlRPCsISRQLRVSHGCVSKILsRYpETGSIRPGsIGGSKP+.VsTP-V.s+IcEYK+psPuIFuWEIRD+LLp-GVCDppslPSVSSISRlLR	.......................................................putVNQLGGVFVNGRPLPs..sl..Rp+.IVE.LA.+.p.G.l.R.PC.DI..SR.Q...........L................+..............V...............SH............GCVSKILu........R........Y.hETG.S..I..+.P..G.s.I...G.G..S.K.P..............+........V.............A...TP.....c..........VVp+Itp.YKRc..sP..shF....AW..EI...RDRLLs..............-Gl...CspsslP.....S........V......SSIsRllR........................................................	0	161	211	439
+3677	PF03535	Paxillin		Paxillin family	Griffiths-Jones SR	anon	PRINTS	Family	\N	19.20	19.20	19.30	19.50	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.48	0.71	-4.50	6	135	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	44	6	60	102	1	163.20	41	33.41	CHANGED	ssPP.V.sPPSu-sLNGo......pWs.usppatsppP..ppsPhh.sStsKs..........SSsssssuEEEHVY........................SFPNKQKSuEsSsssMoSSLGSNLSELDRLLLELNAVQcSsP.uFPu-Ett.uPPLPuusss+Y.l.ENusSsssKsuPPspEKPKRN.uG+slEDVRPSVESLLDELESSVPSPVPsspsup.u-hsuPQcsssSQQ	..........................................................................................................................................tp.s..u.s...s..s..s..t.s...u-c-HlY........................Sh...PsKp...+S...u-Puss.s...h...SSS...LGoNLSELDRLLLELNAVQaNss.....u.........Fss..p...............-t......t...usshPss............Epsss.shpsss....c+.P.ts..sphh--hRPoVEoLLspLEsuVPs..........ss........s...p..t.p........................................................................................	0	4	9	28
+3678	PF03717	PBP_dimer		Penicillin-binding Protein dimerisation domain	Yeats C	anon	Yeats C	Domain	This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.03	0.71	-4.21	165	11499	2009-09-13 02:10:02	2003-04-07 12:59:11	10	19	4376	46	1966	8801	4788	176.10	24	27.45	CHANGED	hl.stRGpIh........DRs......Gph.LAsstsshs.......lhhsspphpptpt......................................................hpcLuplL.t....hs....pclpp...........................................................................................................................................tttpshp.lhltc............................pls.....cphsplpphthp.....................Glthp.sp..pRhYPp..us...hsupllGalst.......................................................t.thG....psGlEpta-phLpGpsGtpp.hps..cstGp.hltphp	...................................................................................................................................................................................................stRGpIh...............DRs......Gps...LA.tstsshs...........l..hh..s.....p..p.ht.p.t.t.p..h..............................................................hppLupll...p......hst.........pplpc........................................................................................................................................................................................................................................................................................................................................................................................t...pt..t.p..p.h..p..hh..hltp...................................................pl.s.....pp.h....t...t....lpp..hthp...........................................Gl.php...sp...pRhY..P..t...Gp......hhupllGassht....................................................................t.ttthG...ppGlEpta.-...........c......h...........Lp....G.p.s.Ghpp..hph....Dph.Gphl...tt........................................................................................................................................................	0	675	1302	1665
+3679	PF01395	PBP_GOBP		PBP/GOBP family	Bateman A	anon	Pfam-B_1765 (release 3.0)	Domain	The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors [1]. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.75	0.71	-4.49	158	2289	2009-01-15 18:05:59	2003-04-07 12:59:11	17	9	218	135	802	2480	0	116.50	15	75.34	CHANGED	hhhhh..ht.........hhtphtpph.........pphhppChpc...h.slsp.ctlpphpptphsss.........pphcCahpClhp.p..hshhs....psupl..p..hctlhphhtthhtt........pphpph.....lppCt.......stssss...CcpAap.hhp....Chhpppt	........................................................hhh.....................htthhptChpp...............tlst...p.t...h.p.p.h.t.p.h..p..h.ss..............pphpChhp.Chhp.c..hs.l.hs.........ps.u.p.h......p...hc..p..h.hp.h.htthhtt..........pphtph......hppCt..............ttptps.......tC...p...t.uhp.hhp....Chhp...h...................................................	0	184	287	686
+3680	PF00427	PBS_linker_poly		Phycobilisome Linker polypeptide	Finn RD	anon	Pfam-B_159 (release 1.0)	Family	\N	24.60	24.60	24.90	30.90	22.60	24.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.86	0.71	-4.48	152	614	2009-01-15 18:05:59	2003-04-07 12:59:11	16	8	108	15	206	625	257	129.90	39	46.64	CHANGED	hpsssspschp..plIpAsYR...QlaspphshpspR..hsslE.SpL+sGpIoVR-FlRuLupS-hY+ppFapsssshRhlELsa+HlLGRuPhsppEhtta.plluspGhpuhIDuhl-SsEYtpsFG-csVPY.Rs	...............h....hopsphptlIcAuYR...QVhu..pp..h...h.hp..spR...hsshE.SpLcsGpIoVR-FlRuLApS-hY+cpFapsssshRhlELsa+HlLGRuPhsppEhttahplhus...........pGapAhlDuhlDStEYtcsFG-ssVPY.R.............	0	28	118	181
+3681	PF03792	PBC	PBX;	PBC domain	Finn RD, Mistry J, Burglin T	anon	Pfam-B_3021 (release 7.0)	Family	The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins [1][2]. 	25.00	25.00	26.00	27.40	20.10	23.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.37	0.71	-4.61	8	415	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	103	0	176	302	0	161.20	75	49.67	CHANGED	Shu.....phtpslu-lLQQlhsITDQSLD.EA.QARKHuLNsHRMKsALFsVLCEIKEKTsLShRss.......E--PPDPQllRLDsMLlAEGVuGP.........-cuGstuAsuuusss......ssohEHuDYRAKLuQIRpIYHuELEKY-pACsEFTsHVhNLLREQSRoRPISs+EIERMVsIIpRKFsuIQhQLKQSTCEAVMILRSRFLD	.......................t.........p.hptlhtI.s-psLD.-s..pt+..KasLss.HRMKPALFs.VL.CEIKEKTs.LSIRusQ......EE-PsD..PQLMRLDNMLLAEGVuGP.........EKGGGuA....AAAA..AAAAoG......sssDNSlEHSDYRAKLuQIRQIYHoELEKYE...........QACNEFTTHVMNLLR.EQSRTRPIoPKEIERMVuIIHRKFSoIQMQ....LKQSTCEAVMILRSRFLD..........................	0	32	51	106
+3682	PF02229	PC4		Transcriptional Coactivator p15 (PC4)	Bateman A, Mian N	anon	Pfam-B_6534 (release 5.2)	Domain	p15 has a bipartite structure composed of an amino-terminal  regulatory domain and a carboxy-terminal cryptic DNA-binding  domain [1]. The DNA-binding activity of the carboxy-terminal is disguised by the amino-terminal p15 domain. Activity is  controlled by protein kinases that target the regulatory domain.	20.60	20.60	21.10	20.90	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.70	0.72	-4.74	203	1136	2009-09-14 14:13:59	2003-04-07 12:59:11	11	16	977	22	344	696	66	53.70	41	52.06	CHANGED	sh......hph..utp+clslppapGp.shlDIR-aat..c.s.t..hP..spK.GIoLoh-p......hptLtchl	...................u..spp.GapKclshlSaNGt.sKaDIRpWss...D+s.+..........huK....G..ITLosEE......appLhct.h................	1	134	213	285
+3683	PF01851	PC_rep		Proteasome/cyclosome repeat	Bateman A	anon	[1]	Repeat	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.40	0.73	-7.87	0.73	-3.42	157	1407	2012-10-11 20:00:59	2003-04-07 12:59:11	17	15	352	4	875	1693	10	34.70	28	7.63	CHANGED	uAshulGllttG.sssp...tshphLp..ph.h..sspsshtt	...uAhhuLGLlhtG.ossp..pllphLhsh.hp.pspp.h............	0	256	433	695
+3684	PF01135	PCMT		Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	Finn RD, Bateman A	anon	Prosite	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.23	0.70	-4.80	9	3573	2012-10-10 17:06:42	2003-04-07 12:59:11	14	23	2359	22	1324	13744	3799	199.20	32	79.48	CHANGED	tp.pptLlcpL+ppGhlto-+VhcAMtsl-RpcFlsc.....tsYhDsPhsIGas.....sTISAPHMhAhhhEhLc..LpsGh+lL-lGoGSGYhTAshAphVGppG.....hsluIE+I.cLstpuccNlcp.shp......sVhlhhGDGphGasthAPYDAIaVuAAuPclPpsLlcQLcpGGRLllPVG...stpQhlphh-Kps.Gpl.h+shtsVhaVPLsspct	.....................................................................................p...thl.p.p.h..h..t...t.s...l.p...s.tp..VlpAht......t..l...P..Rc.h.Fl...............s..........t..........s........h...t...........p.....t......A.....Y......p.......s......t......s....l...P..I..u..t.u............................po.I...S..p..P.....h...h.....l......A.....+...M...h...c.....h....L.p..............l..p......s.........s....s.........+....V..L.EIGo.G.S.G.Yps..A....l....L...A...c...l....s........t.....c....s...h..........................ol.E......+.h.p........s.....L.t....t..p.A...+.....p.....p.....L.....c....p....h...s.h.p.......................................N.l.p...h.....t.....h.....G......D........G.....h.......p.........G......a.......s.....s........p.........A.........P...........a.....D......s......I.......l......V........s.......A......A........s.........s..........p..........l........P.........p........s..........L..........h........p........Q........L....p...............GG..h.....L.......V...h.......P...l.........G..........t.........tt............Q.....h.l.h.h.l.p..+.....p..s.............s...ph.....p..l..s..haVPlh....t.........................................................................................................	0	387	810	1083
+3685	PF00705	PCNA_N	PCNA; 	Proliferating cell nuclear antigen, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_598 (release 2.1)	Domain	N-terminal and C-terminal domains of PCNA are topologically  identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.	20.30	20.30	20.60	21.70	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.51	0.71	-4.62	13	917	2012-10-02 11:47:48	2003-04-07 12:59:11	13	9	610	146	433	892	363	118.30	32	46.62	CHANGED	MhEARLlQGSlLKKVLEulKDLls-AsFDCSuoGlsLQAMDSSHVuLVuLpLRSEGF-cYRCDRNluMGhNLsSMuKlLKCAGN-DIlTl+A-DsuDTlshlFEsssp-+ls..DaEMKLMDlDsEa	.........................hEsch.pu.slLK+ll-ul..+..-L.lp-..ssa...........-.ss.p.sGlp....lQuMDsSHVuLV..sLhL.pscuFp.c..Y..+..C..D...+.........s.h.sl.GlNls.shsKlLKpus..sc.D..hlp.l..c.t...........c.-.s.s......-..s.l..s..h....h..h..Es.p..pc...+...hs..phchh.hp..............................................	2	146	247	355
+3686	PF02747	PCNA_C		Proliferating cell nuclear antigen, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_598 (release 2.1)	Domain	N-terminal and C-terminal domains of PCNA are topologically  identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.	20.60	20.60	20.60	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.51	0.71	-4.22	12	906	2012-10-02 11:47:48	2003-04-07 12:59:11	10	9	585	135	428	908	335	118.50	31	47.57	CHANGED	GIPEpEYsslV+MPSuEFARIC+DLSpIGDsVVISsoK-GVKFSssGDlGsuNIhhpQsosVDK.E-AshIEMsEPVsLTFALRYLNtFTKATPLSspVTlShSu-lPlVVEYKIA-MGal+aYLAPK	.................................................................................IP-...cY..sshlphsSsEFt+Is.+DLpp.h.u..-.....s......l.h..I..ps..s..K.-...u.l..pF..s..sp.G..-.......hG.s.uslhl...p....p.........p......h...-..c.......-.p.......t.....l...plph...p.-.s.Vs...h.oF..ul+YL...ss.F...s.K.A.s.s.L.u.s.pVplph.us.-..h.P.lhlcY.p.......l......t.......s.....h.....G.h.l.paaLAP.........................	0	155	249	354
+3687	PF02429	PCP		Peridinin-chlorophyll A binding protein	Bateman A	anon	Pfam-B_2945 (release 5.4)	Domain	Peridinin-chlorophyll-protein, a water-soluble light-harvesting complex that has a blue-green absorbing carotenoid as its main pigment, is present in most photosynthetic dinoflagellates. These proteins are composed of two similar repeated domains. These domains constitute a scaffold with pseudo-twofold symmetry surrounding a hydrophobic cavity filled by two lipid, eight peridinin, and two chlorophyll a molecules [1].	20.10	20.10	22.20	21.40	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.90	0.71	-4.08	9	449	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	30	13	0	428	1	140.30	71	79.66	CHANGED	Dp.IGcAAKpLSEASYPFlK-IDWhSD....lYlKsLPut.ss.pshcAIDKMIhMGAshDsshLKAAApAHH+AI.GSID.ApGVTShADYsAVNAALGRhlASVPKupsMDVYNuhAsh.hssslsstMFupVNshDApAAhKAFhsFKDVV	......................DcIGsAAKtLuDASYsFhK-lDW.ss....laLp.hPGp.ps.csLKAIDKMI.MGAthDspLLKtAA-AHHKAI.GSIs.spGVTShADa-AVNAALGRlVASVPKQpVMDVYsuhtcI.sDPpVss.MhShVNshDA.pAhpGFhpFKDVV........	0	0	0	0
+3688	PF01884	PcrB		PcrB family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family contains proteins that are related to PcrB Swiss:Q53726. The function of these proteins is unknown.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.59	0.70	-5.11	5	644	2012-10-03 05:58:16	2003-04-07 12:59:11	12	1	623	16	186	1485	1169	227.50	42	96.70	CHANGED	a-llEc+t.lHlTLLDP--ssPEEtlEll...t-uGTDAIMlGGSs..tuVsLDNslRtI+Kl..hsLPIILFPGsssGlSRYADAlFaMSLLNSsNsaWIlG.......ApsLGAtTlpKhs..lEslPMGYlVlEPuss..VGaVG-A+.lPpNKPcIAAhYsluucaLGMRlhYLEAGSGAstsVsEEslclsKsLscssLIVGGGI+SuEpA+chlcuGADlIVTGNllEEssp.lEctl+sltcst	.................................................................................................................................................................................phppW+...HlFKLDP.s...K....p.l....s....D...-.....s...L...-tl...........s.SsTDAlh..lGG..oD.....sVT......DNV...l.+..l..hscl+................caslP..lVLE....lSsl.-u.l...h....P....G....hDh...YalPoVLNSp.cstah.sG.............................hphEAl.K..paG.chhs.....a-Ellh...EGYlVl....Ns-..uK.........VAp.lTcAp.ss.l.s.p-Dlt.AY.Aph.Asc...........hh+l..P..lh.Y.lE.Y.....S..G....s..Y..G...D...l......p...t...V...p...s..l...s...p...p...L.....s.......c.......s....p.......L.....a...Y..G.GGI.pstcpApEMAph..ADTI.VVG....s....l....I....Yc....D.l......cpA.LcTV...ch..........................	0	58	123	158
+3689	PF04194	PDCD2_C		Programmed cell death protein 2, C-terminal putative domain 	Wood V, Finn RD	anon	Pfam-B_19053 (release 7.3);	Domain	\N	30.00	30.00	30.90	30.40	29.60	29.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.31	0.71	-4.65	24	515	2009-01-15 18:05:59	2003-04-07 12:59:11	8	14	299	0	347	505	5	170.90	25	44.09	CHANGED	P.......a.p.a.lss-.Eshp...........shsp.spptplssh-p.tstts...sup....-tc-hhEt......stD+sFp+FpcRlupsPEQlLRY............pasGp..PLhhSpsssssch..........................lPpCs..CGupRlFEhQlhPphlshLcsc...p.s.........uh-WGTlllhsCs+sC.......stsGYh.EEashVQ.-.	..............................................................................................h......h.l.ht.E..................t....p...p..p..tp....h.....t..pp..t.tt..ttt........tt.....................tpp-thEt.........ptD.cs.Fp+Fpp+lu...t.s...P...cQlLRY....................shs..Gp......P.L.hh.osp..s....s.t.p.t............................................lPpCs..CG.upRhFEhQl...hPpllshLchs.....p.s.................................................uh-WG....TllVaTCt..psC...................tst.sah..cEalhlQ........................................	0	120	191	285
+3690	PF04868	PDE6_gamma		Retinal cGMP phosphodiesterase, gamma subunit	Mifsud W	anon	Pfam-B_4858 (release 7.6)	Family	Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit [1], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells [2].	25.00	25.00	67.70	67.60	20.70	18.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.88	0.72	-4.13	5	124	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	56	4	53	95	0	77.10	77	91.72	CHANGED	PPcuT..opusPsAosGPTTP+KGPPKFKQRQTRQFKSKPPKKGVpGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQYGII	.............stsphhusstsstGPsTPRKGPPKFKQRQTRQFKSKPPKKGVpGFGDDIPGMEGLGTDITVICPWEAFsHLELHELAQYGII......................	0	2	6	23
+3691	PF00233	PDEase_I	PDEase; 	3'5'-cyclic nucleotide phosphodiesterase	Finn RD	anon	Prosite	Domain	\N	24.80	24.80	24.90	24.80	24.40	24.70	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.49	0.70	-4.61	8	2707	2012-10-01 20:28:14	2003-04-07 12:59:11	14	49	307	332	1579	2650	61	218.10	32	32.64	CHANGED	YHNhhHAhDVoQosahLLtssulcphho-lElLAhlhAAhhHDlDHsGToNpFplpo..cS-LAlLYssc.SVLENHHluhuh+LLQsEphsIFpNLo++capplhchlh-hlLATDMStHhphhccl+shlpptch............h.hs...c+hpllsLll+AADLSssTKsaplp+RWsthlhtEFFpQGDhEpphGhc..pPMCDRcsA.hlspsQlGFIDaIscPlaplLsDlscc..spslh-tl-sN+	.................................................................YHN....hHAhsVsps......h.............ah.h....l...............................p.................s..........t.................l..................t..............t..h..............h..........s..s..........l....E.h.............h.A.hlhAAhhHDl..D.HsGhsNs....Fhlp.o..................ps..L...A..h..l..Ys......cp....SV.LE..........s..HHh.uhu.h.p.l.L...........p..........p..p..p......h..sI..h..........p.....s..........L...s...............p..c.............p......h............p............p..h.........c..p.........h........l...hphlLAT.D.h..........u.......p..H...h..p..h......l...s..p...h....p....p....h.l.ppt.ph........................................................h..p.........c+h.hl...h.p....h...h.l+.s..uDlSss.................s..+......shc.lpp............p...W...sp...............tlhpEF...ap.Q.................G.D.........hE+..p.h.........s............h....h.............s......P...h...h....D...R............p..............p...s...p................l...s.......p....Q..l.u.FIca.l.s.......hPha..p.t.h..sp.h..h....................................................................................................................................................................	0	624	791	1167
+3692	PF02112	PDEase_II		cAMP phosphodiesterases class-II	Mian N, Bateman A	anon	IPR000396	Family	\N	23.70	23.70	23.70	23.70	23.20	23.60	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.20	0.70	-5.52	5	323	2012-10-02 15:46:01	2003-04-07 12:59:11	10	6	249	0	179	390	31	254.00	25	76.11	CHANGED	Fss..........ssLGQsGGlp-GstouaLlcccusssFlpLDuGollpuls.cLslSKahusshsITlPp.s...h-sushtKsoahlcs+IpsYaIoHuHLDHVuGLVINSPshh.t......p...........................sKKTIaGLsaTIcsLpKHlFNsplWPNLsutGph.h............h.plshh-LsPuEasslTtTThSlls.........................FPlsHuuulhp...hh.....STuFLF+DslS......s-sIlsFGDsEsDpssup.ShptcIWuslAshItpsKLKuIlIECSsPp-oPDspLFGHLoP+aLlpELspLp.......ohssSou.sLssLN...VIloHlKsslAcss......NPccsILtpLcpLsEtssLG.VsIpIsppG	..........................................................................................................ht..ttth.t..h....t.................................hhth-ttsh..h.............................................................................................................h...tshhhhp.ltsahIoHsHLDHlu..G..h..l..l.s.o.st...............................................p..K....l..hu.stTl.pslppthFN.hhWPN...h...ss..st.h.........................................................................................................................................................................h.hpp...s.....................................Sohhhlppp...............................p.hhhFGDsts............Dp....hp....h............p.....t.pplWp..hA.hl.........t..tpL+ulhlEsSa..s.s.s..s.p.p.L.a.G.HLsPphlhtELp.Lt..............................................phs.....t...t........h.....sh......lhl.H.hK...................................................h...t............t..h.h..................................................................................................................	0	41	97	144
+3693	PF00341	PDGF		PDGF/VEGF domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.80	20.80	22.80	21.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.53	0.72	-3.87	57	855	2012-10-02 16:54:34	2003-04-07 12:59:11	12	13	154	99	329	797	0	80.20	36	33.29	CHANGED	CpPR-slV-lhpEasspsst..hap..PsC.VslhRCu...GCCs.c.EulpCsPopspslohplhcl............ttt.spphhhlshtpHspCcC	......................CpsRphlV...-l...hp.Eh.....ss.p..s.st...hFh..PsC.V.lh...RCu...G...CC..s...s...culpChPo..p.spplshplh+l..............................t..hp.p.phsplshtpHppCcC.......................................	0	40	65	165
+3694	PF04692	PDGF_N		Platelet-derived growth factor, N terminal region	Kerrison ND	anon	DOMO:DM04730;	Family	This family consists of the amino terminal regions of platelet-derived  growth factor (PDGF, Pfam:PF00341) A and B chains.	24.90	24.90	24.90	24.90	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.73	0.72	-3.48	10	162	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	44	9	51	136	0	73.90	43	34.82	CHANGED	EEssIPcELIERLu+SEI+SISDLQRLLEIDSV................usEDssppcl+ppps+sspH.....h.-h..+sl.SRRKRS......lEEAVPAl	..........................pts.IPcELhEhLucSpI+SIcDLQRLL......c..hDS.V.................tEDsh-tsLph.ppsHss.pc...............p....Rt+RS..........hE.Al.A.......................................	0	2	6	18
+3695	PF00800	PDT		Prephenate dehydratase	Bateman A	anon	Pfam-B_1095 (release 2.1)	Family	This protein is involved in Phenylalanine biosynthesis. This protein catalyses the decarboxylation of prephenate to phenylpyruvate.	20.60	20.60	20.60	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-11.10	0.71	-4.74	134	4375	2009-01-15 18:05:59	2003-04-07 12:59:11	13	27	4002	7	1176	3130	2645	177.50	33	54.29	CHANGED	luaLGPpGoaScpAAh....phh.......stssphlshsohp...............clhcuVppsc...s.-hullPlENSh..pGsVstohDhL..hp.t..s..................lpIhuEhh...l.lcHsLhstsss............................ph..pc.Icp........lhSHPQAluQCppaLppp....sphp..hhsssSTAtAAch.....t....................pppts.....sAAIuuphAAchY.uL.plltc.sIpDpt.sNhTRFlllucpts	....................................lAaLGPcGoaochAsp..........................phh.........................tph..ph...h..s..hs.s.hp......................................-lhp.sVc...sGp............s.-auVl..P..lE...N..oh....pGu.lspshDhL..hc..s.....s.................................lpIsGE.hh...lsIcas.Lls.t.sss.........................................................ph...pp..Ic..p............la..SHP..............Qu...........luQCppaLppp.........s..p....hc...h.sssSTAtAAch........l..t...........................t.p.s.s..........sAAIus.c.t.uA.p..hY.....GL.p...........lltc..sI..........p-.p.p.p.NhTRFlllucp.s...................................................................................................	0	367	767	1005
+3696	PF03740	PdxJ		Pyridoxal phosphate biosynthesis protein PdxJ	Bateman A	anon	COG0854	Family	Members of this family belong to the PdxJ family that catalyses the condensation of 1-deoxy-d-xylulose-5-phosphate (DXP) and 1-amino-3-oxo-4-(phosphohydroxy)propan-2-one to form pyridoxine 5'-phosphate (PNP). This reaction is involved in de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate [1].	24.50	24.50	25.20	34.70	22.80	24.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.54	0.70	-5.22	9	2100	2012-10-03 05:58:16	2003-04-07 12:59:11	8	4	2052	50	516	1491	2175	235.70	50	96.84	CHANGED	hhLGVNIDHlATLRpARssthP-slcAAhlAtp.AGADtITlHLREDRRHIp-pDlhhlpclhpsc.....hNlEhulo-Ehht.......lALcs+PcpVsLVPE+RpElTTEGGLDlstttp+lcshlccLpssGhcVSLFIDss.cpIcAutpsGAshIELHTGtYAsh+s...................cscptcp.h...hp+lppsAthAt-lGLtVsAGHGLsYpNVpslstI.t..ltELNIGHullucAlahGLtpAVtcMtplhtt	...................h.hLGVNIDHlATLRNAR.........G..s....s.........aPDPVpAAhlAEp.AGADGITlHLREDRRHIpDcDVphL+.p.slpT.+.............hNLEMAlT.-.E.M.ls.................IAlch+....P.chsCLVPEKRpElTTEGGLDV..su....p..t..-+lpsssp+Lps.A..GI.cVSLFID..s..D..t..cQ.....IcAAtc....l..GA..s.hIElHTGsYA.c.A..p.s......................cs..c..p..t..pc.........htRltpuAphA...ts..L....G.......LpVNAGHGLsYcNVpsl..........Aulsp..lpELNIGHuIIu+AlhsGLppAVt-MKplh..h.............	0	150	324	427
+3697	PF00595	PDZ		PDZ domain (Also known as DHR or GLGF)	Bateman A	anon	[1]	Domain	PDZ domains are found in diverse signaling proteins.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.67	0.72	-3.80	58	26099	2012-10-02 11:12:46	2003-04-07 12:59:11	19	730	2536	601	11639	33290	6344	80.30	22	16.19	CHANGED	plpltt...ttttlGhslssssst..............slhlsplhtG..uuAptss.lchGDpIlpl..NG.....pslpsh.sppcshthlcsssp.....plpLtlt	......................................................................................h.....h...tttshGhsltsspst.........................................................sl.h..l.s...p...l........h....tu.....u.....sA.p.....p..s..........G..L.......p...........s............G...Dp.......I..l.......p.........l.........NG..........................hs.l....p...s....h........s........p..p...c..s....l..p..h..l..+..p..stt.......tlpL.l.h.......................................	1	2855	4028	7376
+3698	PF00544	Pec_lyase_C	pec_lyase; 	Pectate lyase	Bateman A	anon	SCOP	Domain	This enzyme forms a right handed beta helix structure. Pectate lyase is an enzyme involved in the maceration and  soft rotting of plant tissue. 	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.59	0.71	-4.85	10	1509	2012-10-02 14:50:22	2003-04-07 12:59:11	14	45	449	44	752	1578	23	190.70	27	45.93	CHANGED	spslVIsustohD..............uhs.hsh..pphhhG...hGussplsNhGhtlh...psoSNVIl+NlpIcsh.......l..t.t....sssspDGDAIplp.Nus.slWIDHsolSsusapss.hs.........aDGLlDIpcuSssVTISNshFssHcKshLhGH.uDst.upDpG.h+lTlsaNhF.sslspRhP.RsRaGhhHlaNN.Y.......sphppYuhGlussuoILSEuNpF	.................................................................................hh...................................................................t.t.......lh.l..s..S.....p..c.Tl...G........hGs..s.s.t...lts...h.....G..ht.lt..............t.s.....s........N.....VIl+..N.lplpsh.....................................................thhs.s..uD..u..lslt.......s.....u.......s.....plWlDHs..s.hs..s.s..........................................tDGl..l....Ds......h..p.....u.o...st.lT..l.S.ps.h....a..............p..............s....+.....s...c...........s..h..L..h..Gp...sc..p......st...D....ps....hp.....lThtaNaa..p..........shsp...........Rh.P...+...h.....R......h....G........h........h...H.......l..hNN.a..............................t..p.h.....h.....a.uh.sss.....t.s.s..p.lhspsNhF..............................................................	0	220	471	647
+3699	PF05041	Pecanex_C		Pecanex protein (C-terminus)	Moxon SJ	anon	Pfam-B_5192 (release 7.7)	Family	This family consists of C terminal region of the pecanex protein homologues. The pecanex protein is a maternal-effect neurogenic gene found in Drosophila [1].	19.80	19.80	25.70	20.80	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-5.32	8	305	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	96	0	180	282	2	209.20	49	13.85	CHANGED	psVcpDc..DSsLVTLCauLslLuRRuLGTASHs.hSsuLEsFLYGLHsLFKGDFRITs.+DEWVFADhDhL++VVAPAVRMSLKL..HQDHFossDEaDE.ssLY-AIssacpphVIuHEuDPuWRsAVLuspPsLLuLRHVhDDGsDEYKlIMLs+RaLoF+VIKlN+ECVRGlWAGQpQELlFLRNRNPERGSIQNs+QsLRNlINSSCDpPlGYPIYVS.......PLTTSas-opsQL	................................................................h.....t...s.ssLlsLshuLslluR.R.u.L.Gs.Auap.....hu........ss.l-sFLaG.LHsLFKGDF....R....Ios.+DEWlF.u.Dh-LLppVVsPulRM.oLKL..HQD.pFsss...-..E.a..-..-s..tsLa-AI........psaEp.....p.....hlIuHEuDP..sWRpAVLusp.PpLLuLRH.l......h.D.-Gs..s..EYKlIMLp+p.aLoF+VIK.......lN+ECVRGLWAGQQQELlFLRNRNPE.RGSIQNsKQsLRNhINSSCDQPl.GY.PIYVS.......PLTTSa.sop.Q............................	1	53	65	112
+3700	PF03211	Pectate_lyase		Pectate lyase	Mifsud W	anon	Pfam-B_2273 (release 6.5)	Family	\N	25.00	25.00	27.90	27.20	19.20	20.30	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.25	0.70	-4.94	12	678	2012-10-02 14:50:22	2003-04-07 12:59:11	8	10	217	9	311	638	4	205.80	33	67.04	CHANGED	ushussssss...tsuuspshpsoIpVttGpsaDG+stpasus.pshussspu-pQcPlFhLEsGAoL+NVllGtstuDGlHCpG....sCsIpNVhapDVsEDAlTlKupu......sspIssuuAhpAsDKVlQhNussolslps...FhAsDaGKLhRosGssphpt.....sslphsssssssshtuls+s.uDssplpssshph.....ssVsptacGsp....usspssc	.....................................sss.........P.....susss..hsl..sps.hhVtsGpsa..D..G..thppastu.....hs..h..u..ss..sp.s.tppcslFhLcsGATLKNlIl..G.....ps...tt-G.lHCcu....sCsl-NVaaccVsE..DAlol..Kupuss...................shplhGGuApsAsDKVhQhNGt.G..s............lpIcs...F.hsp.ca.GK.....lhRSCGsCps....p..........p...............s.........sl.s.s.p..s.h..s.s.ss.....sl.hulNpNhuDpsolpsh.s.lph........tth.p.ptapt.t...........stt.......................................................	0	88	194	287
+3701	PF04191	PEMT		Phospholipid methyltransferase 	Wood V, Finn RD	anon	Pfam-B_14367 (release 7.3);	Family	The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids [1].	21.70	20.30	21.70	20.30	21.60	20.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.21	0.72	-3.93	105	2350	2012-10-01 22:51:20	2003-04-07 12:59:11	8	12	1459	0	1059	3719	1768	101.80	20	45.04	CHANGED	hphhhGhhLhshGhhlshsuhhsLGhtGsahGDaFh..hhp..t.......hlpsusaphhsNPhYhuushshhGhuLh.tssshs.lllshlshlhhhhhlt.hEcPahtclYuppt	...................................................................hh...hhuh.hl.h.hh...u.h...hh..h....h.......u...h.h...t..h...t...h.t...t...s..h..h.s.....s..............ttsp.p.............................LlssGsYp..h.sRpPhY.hu.h.h.l.hh.h.......G...h...s..l........h.....hs....s...h...h.........s.....llh...s.....h......h..h......h...h.h..h.h.hh.hhhh.EE.thl.t.phaut.................................................................	1	349	655	903
+3702	PF03965	Penicillinase_R	Pencillinase_R;	Penicillinase repressor	Finn RD, Bateman A	anon	DOMO_DM03102 & Pfam-B_5099 (release 14.0)	Family	The penicillinase repressor negatively regulates  expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerisation of the  protein [1]. 	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.36	0.71	-3.99	47	2958	2012-10-04 14:01:12	2003-04-07 12:59:11	11	9	1713	20	713	2659	173	112.30	25	82.47	CHANGED	lustEhcVMcllWpput.sosp-lhpt.Lspt.hth..uhoTVtTllsRLhcKGhlspc+p.G+tahYpshlscpphhpttscpllschhts.shsshlsphlcpp..tlotc-lppLpphlpp	......................lopsEhclMc.llW......p......p.....s......p.....h.....osp.-lhpt..L.....p...........c............p....h....p....h..sh..sTltTlls.R.L.h.c.Ksh.lp.....p.....c......+......p.....G....+.....t.....a..h..Yp..s..hls.c.c....ch.h.pt.ts.ps..hlsch.h.s.s...sh...ts.h.ls.phlppp...plo.tc-...lccLcphlp...............................................................	0	301	536	647
+3703	PF00805	Pentapeptide		Pentapeptide repeats (8 copies)	Bateman A	anon	Bateman A	Repeat	These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK [1]. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix [2]. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.50	0.72	-4.66	95	11082	2012-10-03 04:02:01	2003-04-07 12:59:11	17	346	1513	31	3972	17635	5755	38.50	33	30.01	CHANGED	usLpsAsLpsusLpsusLptAsLssAslpsAsLpsuslps	.........................pLttAsLp....s.....AsL.....p......s.....A....sL.....p.s....A.s.L......p.s.A.....s...L.....p......s.A.sLpsupl.......................	0	1098	2769	3557
+3704	PF00354	Pentaxin	pentaxin; 	Pentaxin family	Finn RD	anon	Prosite	Domain	Pentaxins are also known as pentraxins.	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.30	0.71	-4.88	9	1094	2012-10-02 19:29:29	2003-04-07 12:59:11	12	93	109	168	564	1160	95	183.20	29	30.79	CHANGED	KsFVFP+ES-TsYVpLhs.LcKP.LpsFTlCh+hYo-LS..RuaSlFSYuTpp..pDNElLlahc+sspYShhlGss...clhh+s.EphsuPsHlCsSWESuSGIsEFWVsGK..PhV+KuL+KGYTVtspsSIlLGQEQDSaGGsF-toQShVGEIuDlpMWDhVLoPEpIpolYtG.sshs....sNILsWRuLsYElpG.Vhl+P	...................................................................FP...t.st...sas..ltsp.hths...L.puFTlC..hh..h.t.s..shs.......p.h..o..h...F..SY.us...s......p.s...N..-l....l.l............h...t......p.......t......t............s...s...h........p.........l......h...l...ssp.....................t.s..h..h...............h................t........s.....s...p.W...pH.l.C...soW...s.....o...p....s.Gh.hp.....hahD.Gp....................h.s.s...t..p.s..............l.....t..t..u..a....s..l....t...s.......s.G..s...l...l.LG......Q....-Q..D........s..............h....G.........G........s.............F.......-..s............s.....Q.......u...F...lG...-.luplshWDpVLo.sp.pl.....t.s.l..h..ps........p.h.p........GN..ll.sWtshphp.h.s............................................................	1	154	195	378
+3705	PF02896	PEP-utilizers_C		PEP-utilising enzyme, TIM barrel domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.60	19.60	19.60	19.60	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.91	0.70	-5.54	17	9485	2012-10-10 15:06:27	2003-04-07 12:59:11	13	33	4444	34	2008	6852	3404	301.30	34	43.25	CHANGED	+tt.uphtsh.uhssDGp+lclhANlupsp-stsAhssGAEGlGLhRTEalahsp.sp.hPsEcE....................QhpsaculhcAhsG+PVslRTLDlGuD..KtLPa.h.............................chspEhNPhLGaRulRlslsp..s-lhcsQlRAlhRAus...hu........plpIMhPMluohpElcp.s+pllcch+tplctphhth.s.shplGhMlElPuAAhhA-phA+c.sDFFSIGTNDLTQYThAhDRtsst....lual......asPhpPulL+hlppllctAcpcG......hhlGhCGEhuG.DPpul.lLlGlGLDphShSshul.ts+thhtphph	...........................................................................................................t..ht..shs...c.s...p...pl.clh.sNluss.p..-.s...t.s.shp..G....A-GlGLhRTEalahsp....s.....p.....hP.s...cE.............................................................................Qhpsa.p.p.lh.p...u.h......t..s..+....s...V.ll..Rs.h....Dh.su.c......+...Lsh..h................................................................................................t...s.cE..t.NP..hL..GaR..u.lR....ls..l..sp.....s-laphQ.l.RAll.RAus.....ts..................slcIM...lPhlsolcEh.......c..........t...s+.p...l.......l.c..........c.t........t....t.p.l.........t...p...p..............h.....h...p...t.....s.....l...c.lGhMlElPu.sAhhA-p.h..u........c.......c.......s.......D.........F...FS...IGTNDL...T...QashAhDRssst..........lutl.................asshs.P....ull.chlppllcs...A..c....p.pG........................thl.GlC.GEhuG.D.s.p.ss...hLl..s.h.....Gl-plShss.s..s.l.sts+hhltph.h....................................................................................................................	0	656	1260	1670
+3706	PF01327	Pep_deformylase		Polypeptide deformylase	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	22.00	22.00	22.00	22.60	21.30	21.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.89	0.71	-4.83	130	7120	2009-01-15 18:05:59	2003-04-07 12:59:11	16	13	4525	176	1596	4663	3258	154.60	34	87.31	CHANGED	hhpIlphs-s....hL+phupsVp...phs...sp.lppllccM..h-...TMhss.s............GlG.LAAPQlGh..shRlhl....lchsppptt.....................llINPcl.................................................hsp......pthtttEGCLSlP.....s....hhspVpRspplplchhD.hpGpphph.c...hpG.......h.hAcslQHEhDHLsGhLalD+.....lsphcpt	.........................h.hpIlphscs....hL+ph.ucsVs...ths...........sp.lppLlcDM......h-TM..hss..p......................................GlG..LAAsQlGl..spRlll.......lc....ls..p..ppst.......................................lhlNPcI...............................................................t.p.p.......t..p.....s..t.tEGCLSlP..........s..hhu.V.t.Rhpclplch...hD...t.....p............G....pt...hpl..c...scG.......h..hAhslQHEhDHLsGhLFhD+ls..p.t................	0	529	1053	1351
+3707	PF01562	Pep_M12B_propep		Reprolysin family propeptide	Bateman A	anon	Pfam-B_117 (release 4.0)	Family	This region is the propeptide for members of peptidase family M12B.  The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  --amino -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.60	0.71	-4.36	119	2978	2009-09-11 14:07:58	2003-04-07 12:59:11	14	104	182	0	1366	2653	2	126.10	24	15.43	CHANGED	hEllhPp+lp.......................................................hpttt..............ph....splpYplphpGcphhlcLcpscthlussashh...............pYspsGsh.hspps.ht....scCaYpGtlpu.s..s.S..hVul..SsC.uGL+Ghlphp.stsYhIEPl........pts..ssh........pHllY	.................................................................................................................................t..................th....tphpap.l.ps...G.c.ph...hLcL.p.h...s....p.p.l...lu.ts.ashp......................hh.s....p.s....G...pt...hspt.s.................pcCaYpG....p..l.ps.ps.....s....S...........hsu..l..SsC...s...G...L............c........G.hhp.hp...s...ts.YhIE.Pl...........pts......sp.................Hhla...............................	0	218	304	662
+3708	PF03413	PepSY	Pep_M4_propep;	Peptidase propeptide and YPEB domain	Bateman A, Yeats C, Rawlings N	anon	Yeats C	Domain	This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase & Bacillus subtilis YPEB. 	20.90	15.00	20.90	15.00	20.80	14.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.15	0.72	-3.33	348	4684	2012-10-01 23:09:26	2003-04-07 12:59:11	14	98	1721	4	837	3397	168	65.70	19	24.77	CHANGED	tlo..hppA.hphA.........tpp...............h.......s....st.hhp....hphttt...................................psphsYc.lp.hp............sstt.........hph...lDAtoGcllppp	.....................................................................................lo.cpA.hphA.................hpp.................................h.............s......sp..hhp........hp.tpp............................................................psphsYp..lp..lp...................sstp............hchh....lDAp.oGcllp........................	2	290	543	701
+3709	PF00311	PEPcase		Phosphoenolpyruvate carboxylase	Finn RD, Coggill P	anon	Prosite	Family	\N	20.60	20.60	20.80	20.60	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	794	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.50	0.70	-13.20	0.70	-6.70	65	4128	2012-10-10 15:06:27	2003-04-07 12:59:11	12	6	3076	5	773	3411	2728	540.50	36	85.56	CHANGED	pLslcLVhTAHPTElsR+ollpKp++IuphLppL-p.phsspcc.................pplcppLpccIphhW+TDElRph+PTVlDElchuLpYFcpsLaculPplhcclppsL....pppasthphPh..........shhpFGSWlGGDRDGNPsVTs-lThcshphQRphslchYlpslcpLhppLShS..hspsss-Lhpplcpcpt..............phschh.ph.t.h..pEPYRltLuhlppRLtsTpcc.pphhssp......................hsssphYpssp-hhp-LpllpcSLppsu.t.lusspLtcLlppVcsFGhpLspLDIRQESs+Hs-slsElscaLsl.....stsYsphsEp-+htaLhpELps+RP.L.....lPs.......ph.....shSccTpEslssh+sltclppcaGscshpoYlISMscssSDlLpVlLL...t+EuGLhpssss.............spLtVVPLFETl-DLcpAPplMppLhslPhYRphlss..............................shQEVMLGYSDSNKDuGhloSsWpla+AQcsLtclAcca....GVpL+LFHGRGGoVGRGGGPu.apAILAQPsuol.sGpI+lTEQGEVlusKYuhP-lAhtsLEhhssAllpAS..Llsss.sp.......ppWpplM-cLuspSpppYRsLVaEpP-FlsaFppsTPlpElupLsIGSRPA+R....+s..stslpuLRAIPWVFuWTQoRhhLPuWaGlGoALpphh...tpssp.....plphLcpMYpcWPFF+shISplEMsLAKsDLpIAppYsppLs.ssc.tct...lappIppEaphTpchlLplTsppcLLsssPs............LpcSlpLRNsYlsPLsaLQVpLL+RhRptspp.............................pphscs-hLcsAL.LTINGIAAGMRNTG	............................................................................................................hhTAHPTp....sh.........h.....h.........................................................h.....h...h.o........ps.sEhp.sh.hhppshhpslPphhpchp....p..h.....t..t......h..........................lp..hstWhGGDRDGN.P.VTsphht.sh.htt.hh...h...h..h...hs................................................................................................................................................................................................................................th...l..h.t....l.........................h..hh...h..FGh.h..hDhRp...puthattsls.t.l.h....t........h.....th................tpY.tt..hsEtp+.t.h.Lhp...p.L..t.t...R.....L........s.................h..............s.....t........h..t.c..Lthhphh...tth.......tshtthlIShspssSDl.Lt.l......lL.......+.Esth.................................................h.lsPLFEpltDLp.tu.thhtphhshshhpth.l.ts.......................................................hQ..lMlGYSDSsKDuGhhuusWt....YpApptLh....p....h....s....c....p....h.................u...lclphFHGRGGo......lGRGGu...P.s...a....A.l....huQP.......to..l...p.u.tlRl....T.....QGEh.It.p..au....p....hshpsLphhsu.A.h.Lpts...hh........t...sp..................................................pap.t.hM-phu.h.u.h..p.YRsh...Vh.......p.p........p..F...h....YFh.....................tuTP..Ehup.h.s.lGSRPupR.....ps......ts..s....lpsL.RAIPWlFuWoQsRhhlP..sWhGh..Gsuhpth.........p.t..........................p.t.LptM...........hppWPFFpshls.l-MVhuKss..lAth.Ysphh...st.p.h........hhptlhtp.hp.shphlLt..lt.sp.p.p.lhtt.sh..............l.t.pplphR..Yh..ssLshhQ.h.h...lt+.Rt.t................................................thl.hohtGlAs........................................................................................................................................................................................	0	201	483	654
+3710	PF00821	PEPCK		Phosphoenolpyruvate carboxykinase	Bateman A	anon	Pfam-B_1309 (release 2.1)	Family	Catalyses the formation of phosphoenolpyruvate by decarboxylation of  oxaloacetate.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	587	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.87	0.70	-6.35	56	2517	2012-10-02 15:24:17	2003-04-07 12:59:11	13	4	1840	45	434	2002	389	325.30	56	96.18	CHANGED	palp-sscLspP-plalCDGS-cEhcpltpphlcsGphhhLt.p+a.NsaLsRocPpDVARVEs+TFIsopscc-ssPssN............WhsPp-hcppl.pplasGsM+GRTMYVlPFSMGPluSPho+l..GVplTDSsYVVhSM+IMTRhGpplL.....ctL.ssctpFV+slHSVGtPh..s....ptsss.WPCNs.ccphIsHhP--+......pIhSaGSGYGGNuLLGKKCaALRIASshA+...-EG.WLAEHMLIlGlTsPp..GccpYlAAAFPSACGKTNLAMltPsl....sGWKlcsVGDDIAWh+hs.p-GpL.....hAlNPEsGFFGVAPGTu.cTNPsAMpol..tp.NoIFTNVAhTsDG.cVaWEGhspp..Ps...........plhsWpG.......cs.Wp.s....pssc.PA...AHPNSRFTsPhsQCPhlc.PcW-sPcGVPIsAIlFGGRRssslPLVhEAhsWpHGVa.lGAohpSEsTAA.Apupsuhlc+DPhAMLPFhGYNhGcYhpHWLshupc.........p+hP+IFpVNWFR+sp.sG+FLWPGFGENtRV.LcWlhcRlcG....c.ssAhcTPIGhlPphssLslpGL.thspt....s...hcclholststWhpEl.cplcc.aapph.GscLPpplhpcLctlcpRlpph	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sap.hpslGDDI.sWh+...s..tp.....G..pL.....hAINPE.sGFFGVA..PGTshpTNPsA........MpTl........hpN....T.......lFTNVAt.T.s.....DG.sV.a.WEGh-c-h...ss............plTDWhG.ps.Ws..................cstp...PAAHPNSRFss..PApQCPhID.Pt.W.EsPpGVPI..sAIlFGGRRs..p....sVPLVhEAhsWpHGVa.lGAsht......S..........Es....T.AA...A.............t...tp....t..............lh+DPhAMhPFhGYphupYh....................................................................................................................................................................................................................................................	0	144	249	359
+3711	PF01293	PEPCK_ATP		Phosphoenolpyruvate carboxykinase	Finn RD, Bateman A	anon	Prosite	Family	\N	25.50	25.50	25.80	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.40	0.70	-5.97	128	2905	2012-10-02 15:24:17	2003-04-07 12:59:11	15	5	2608	26	690	2097	1598	442.70	48	86.52	CHANGED	sssplhh.NlssspLhEculp........cs.....EGhlsssGALslpTGpaTGRSP+DKFIVc-ssoccplaW......GslNpPhst-pFctLhp+shsaLss+.claVhDsauGADsca.RlslRVlsEhAWpuLFs..+NhFIRP....sp-ELp.sF..cP-aTllsuPsFpAcPtpc.GspS-shlhlNasc+hhLIuGTpYAGEMKKulFol.hNYlLPt.+slLsMHCSANlGp.c..G.Ds......AlFFGLSGTGKTTLSA......DPpR.pLIGDDEHGWs.-sGVFNhEGGCYAKsIsLSpEsEP-IasAI+..FGulLENVVl.ctps+plDasDsSlTENTRsuYPlcaIsNthhss.huGcPcsIIFLTsDAFGVLPPlS+LTs-.QAMYHFLSGYTAKVAGTEtGl.oE.PpsTFSsCFGAPFhPh+PshYAchLsc+l.......pc.asspsaLVNTGWoGGs...YGs..GpRhslchTRAllsAhLsGsL....sssc..acppshFslplPpsls.....GVsspl	..................................................................................................................................ts..plhaN.Shs.Lapctlp.......s................cGhlT.ph...GAlsspT.G.haTGRSPKDKalVc-..s....soc-....plaW.........t..ssNpPhstEsa.ppLhthshc.LssK..claVhDuas..Gu.s.cpR.lplR.h.ls.EhA.Wp..u.hF.s.....+.N.M.F....IR.P............o.p...-.E.......Lt......s.F..........c.......P.D.Fslh..N...u.sp....h........p..s...s.....h..p-...G.h...s........S..E.....shl.hhNhs....c+....h.lIuG.T....Y..u..GE.MKKGhFSh.MNYlLPh..cslhSMHCSAN....s....Gc....c......G...DV...........Al..FFGLSG..TGKT.T.LSs......................DPc..R.....pL.IGDDEHG.Ws....Ds..GV..F..NhE.G.G....CYAKsIs..LS.p.E..t..E.P.-..Ia..s.AI+..hsu.lLE.NV.......sl..c.pst..plDa.sD.s.Sh.T.............E..NTRsuYPI.aIs.....Nhs.....h.....Ps....tuu....Hs.p.p..........lIF..LTADA..FGVLPPlS+L.o.s-.QshYHFLSGaT..A..K............lAGTE.+.......Gl....TE..P.ps.......TFSsCFG....AsFls.LHPopYAchLsc+.h.......pt..t.sspsYLVNT.GWsGs.....................GKRhsl+.TRullsAIlsGsl.......p.pu-......htphs..hFsLtlPsplsGVssp.......................................................	0	226	436	591
+3712	PF01195	Pept_tRNA_hydro		Peptidyl-tRNA hydrolase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	21.70	20.70	19.70	20.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.20	0.71	-4.80	116	4825	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	4548	28	1217	3288	2684	180.00	38	92.48	CHANGED	LlVGLGNPGtcYppTRHNlGFhslDpLsc......chs......hphppppthpuhhsp.h...ht..............sp...cllLlKPp.TaMNhSGpuVttlhpaYc.....lps.ccllVlaD-lDLshGpl+l+tsGusG.GHNGl+SIhppLGo.pcFhRlRlGIG...+...P.....ttt...slssaVLupFstpEtptlpp.slppuscslpthlpp...s....hstshsph.s	...............................LIVGLGNP...GscYttTRHNs........GF...hhlDt.LAc...chs.........hshpp.p......p.........Fpu..h.huc...ht...ls.....................................Gc..clhLl+Pp.T....aMNhSG.cu..V.t...s.l......h....s....a..Y.c...................lss....-....-.......l..lV.l..aD-LDLssGplRl............+.t.......sG...us.........G....GHNG..............l.K.S.....I.hs.p.........L................G..............s.....p............s...............F.....h.........Rl..RlGIG....+.Ps....spt...................pVssaVLucF...s.p.p....E..pt.h.lsp...sl-c.uscsl.phhlpp..s..hppshschp............................................................	0	407	789	1024
+3713	PF03564	DUF1759	Peptidase_A16; Peptidase_A16_N; 	Protein of unknown function (DUF1759)	Griffiths-Jones SR	anon	MEROPS	Family	This is a family of proteins of unknown function. Most of the members are gag-polyproteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.76	0.71	-4.39	8	975	2012-10-02 13:37:57	2003-04-07 12:59:11	10	76	48	0	921	926	2	119.20	20	16.10	CHANGED	FuG-hpEWpsFh-lFpShlHsppcLucl.KFpYL+ShLpG-AAsllpHhsl.TusNYpsAh-tLpcRY-NscpIhpsLhcclhcl.s.sspcssptL+plh-ssscllRtLcplGcps-..DshlspllLpKlspcs+++hlppu+cpcs	............................................FsG.p..h..p.a.tFhp.Fp.shlc.p.tp.ls.s.hp.Khth.L......h..phL....p.G..p.Atphl.p...s.h....h.....ss..t...s..Ypts...hp..hL.pppas.p...p.h...lh.pthhppl.p.h....................ts....tthpt...h...htthpth..h...t..l..pt..h..t.....t......t..........h.........h..ph................tt...................................................	0	563	601	892
+3714	PF03566	Peptidase_A21		Peptidase family A21	Griffiths-Jones SR	anon	MEROPS	Family	\N	25.00	25.00	46.00	25.00	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	648	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-13.09	0.70	-6.43	5	29	2012-10-04 01:49:40	2003-04-07 12:59:11	8	1	9	20	0	36	0	607.00	68	93.74	CHANGED	uDANlAupp..sR+RoRslR..............................................pNP..............ltApsVsVuss+RpRR+RRsG++hss.ssspsAstcluQsLsusolossushooM.PslRshAttclDlussSlGWaaKYLDPAGAsESu+AlGEYSKIPDGLl+aSVDAEhREIastECPsVo-solPLDGupWoLSIISaPhFRTsalAlANlsNc..ElSL-slN-lIpsLNN.luDWRD.lsosQWspFopsssaYhpIhVLpPTYAhhDVPDPT-.GlstoVoDYRLTYKGITsEuNsPTLVDQGaWVGAQaslsPsoEsQpslsc..uGosslusoshhpssuusshthsWA..sLPsGGoAPssssuhT.soSGpFhshchsG.s..uuVhoaTlPpGathEs........ssFAssGDTlTFsh....suGsslslTp......TAPTsTlTlhuohTuossl..sRslss-oG.....hss.l-ssulNRp...plslPPhThuQsssNsPKhEQFLlKETtGsYlVHpKMpNPVFpMTPASSFGuVpFssPGa-hssstsulGGIRDThDsNaSoAVsHFpSLSpSCoIVsKTYpGWEGVTNsNSPaGQFAHoGs.K-DElLsLAccLsscLTGVYPAsDNFAGAVSAhAAshLuplsKSpATuSlIKuVApsAsGslpuuhApLsGllpSl.G+luAR....l+ARRARRRAuRts	...........MDSNSAS....GKRRSRNVR...............................................................IAANTV..NVAPKQRQARGRRAtSRANNIDNVTAAAQELGQSLDANVITFPTNVATM.PEFRSWARGKLDIDQDSIGWYFKYLDPAGATESARAVGEYSKIPDGLVKFSVDAEIREIYNEECPTVSDASIPLDGAQWSLSIISYPMFRTAYFAVANVDNK..EISLDVTNDLIVWLNN.LASWRDVVDSGQWFsFSDDPTWFVRIRVLHPTY...DLPDPTE.GLLRTVSDYRLTYKSITCEANMPTLVDQGFWIGGHYALTPIATTQNAVE....GSGFVHPFNVTRPGIAAGVTLTWA..SMPPGGSAPSGDPAWIPDSTTQF.QWRHGGFDAPTGVITYTIPRGYTMQYFDTTTNEWNGFANPsDVVTFGQT.GGAAGTNATITI......TAPTVTLTILATTTSAANVINFRNLDAET............TAASNRS...EVPLPPLTFGQTAPNNPKIEQTLVKDTLGSYLVHSKMRNPVFQLTPASSFGAISFTNPGFDRNLDLPGFGGIRDSLDVNMSTAVCHFRSLSKSCSIVTKTYQGWEGVTNVNTPFGQFAHSGLLKNDEILCLADDLATRLTGVYGATDNFAAAVSAFAANMLTSVLKSEATTSVIKELGNQATGLANQGLARLPGLLASIPGKIAAR....VRARRDRRRAARMN.............	0	0	0	0
+3715	PF02160	Peptidase_A3		Cauliflower mosaic virus peptidase (A3)	Mian N, Bateman A	anon	IPR000588	Family	\N	21.30	21.30	21.40	21.50	20.70	21.10	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.39	0.71	-4.72	6	102	2012-10-02 15:32:34	2003-04-07 12:59:11	10	11	42	0	23	125	0	173.90	29	22.75	CHANGED	NPNSIYIKGpLhF+GYps.hplchYVDTGASLChAs+alIPEEaWpsuc+PIpl+IANsplIpIsKVspsl.lpluGcpFhIPTlYQQ-oGlDlllGNNFC+LYpPFIQapDpItF+hsp..psV.hpplT+AhhsuspuFLEShKKpSpspp..shNIopsp.....-plshlp.hc....-E+hapth..+hptIEpLLEp.VsSEpP	......................................ht.h.hpshlDTGAslChhpc.hlIPcchW.psppsl.hlphAssphhplshhspplplhIs.s.....chFpIP.plY.....pp...-.....o....s..hDhllGsNFhp.LYpPF.lph.p.-.p.lhFph..st......l.hhttlsps.....hphshpth....hps..hpptpp..spp....shp.....th......................................................................................................................................	0	1	17	19
+3716	PF01828	Peptidase_A4		Peptidase A4 family	Bateman A	anon	MEROPS	Family	\N	21.00	21.00	21.00	22.50	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.49	0.70	-5.27	22	234	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	99	7	175	241	1	194.70	32	70.59	CHANGED	SoNWAGAVL.....sussYTuVoupFsVPpPosssus.................st.suSAWVGIDGD.ThssA...ILQsGVDFhlp..sGpsoaDAWYEWYP-hAYsFsslslSsGDsItlsVsAoS.osGsAhlENhooGpoVo+Tlou...ousLsthNAEWIVEDFppuso......hVshAsFG.oVsFTGApAss.uGpohGhssATll-lc.Qs..spVLTcsolsusotloVpYl	..................SsNWuG.ulh...........sussaosVousasVPssosss.u.............................s.uSuWVGID..G......s....ssssu...............lLQsGl..shp.............h.....p.........sG..p..ss...........asAW.............a..EWa.......P...s..h..u...h.....s..h...s.....s..hs.lssGDplpsoV.s..s..so...s.o.....s..G..s....ssl.p.N.......ho........sG....ps....sopo..hos.........sssL..sttsAEWIVE....D....h...p....t....s..s.s.......hs..sh.AsFG.sVsFos........spAss......sutp..h.....s...ss....u...p....h..hph.....t..tt..s.s..........................................................................	1	28	100	140
+3717	PF01829	Peptidase_A6		Peptidase A6 family	Bateman A	anon	MEROPS	Family	\N	25.00	25.00	324.40	324.20	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.33	0.70	-5.43	3	9	2012-10-04 01:49:40	2003-04-07 12:59:11	11	1	7	40	0	24	0	359.20	60	88.70	CHANGED	AhspNNLh+LSpPGLuFLKCAFASPDFNTDPGKGIPD+FEGKVLo+KcVLTQS.INFT....sN+DTaILVAPTPGVAaW....sAcAPAssuAloTTssFsAVsFPGFsSLFGToATsRADQVoAFRYASMNsGlYPTSNLMQFAGSIoVWKsPVK..LSosQaPVATTPsT..SQLVHAIsGLEulLAVGs-NYSESFI-GVFSQSVCNEPEFEFaPILEGlQTLPPANVTVAQAGMPFNLsAGAtsVAGaTGlGsMDAIsI+VTAPTGAVNTAlLKTWAClEYRPNPNosLYcFAHDSPAsDElALQpYRKVARSLPVAVtAKpNAoMWERVKSILKSGLshASsVPGPVGlAATGlpGIu-LIuuLuF	.......s.hNhsALsRLSpPGLAFLKCAFAPPDFNTDPGKGIPD+FEGKVloRKDVLsQS.IoFs....uspDTaILlAPTPGVAYW....sAsscAushshoTT.sFsuVsYPGFTShFGTTATS...RSDQVSSFRYASMNsGlYPTSNLMQFuGSIoVWKsPlK..LSosQaPVuT..sPAT...SsLV.HsLsGL-GVLAV.GsDNaSESFIKGVFSQSsCNEPDFEFsDILEGlQTLPPsNVslusoGQPFsLsAGuEssoGlsGaGNMDTIVI+VSAPTGAVNoAILKsWuCIEYRPNPNAhLYQFuHDSPPhDElALQEYRsVARSLPVAVhAAQNAoMWERVKuIlKSuLusASsIPGPlGlAASGIpGLSsLhpuhuF....	0	0	0	0
+3718	PF01252	Peptidase_A8	SPASE_II; 	Signal peptidase (SPase) II	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.30	28.10	23.20	24.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.22	0.71	-4.60	181	4771	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	4358	0	1061	3181	2288	151.40	31	88.98	CHANGED	hlsh..hl....lh.lDQhoKhhlhpph.................h..................psh....hlss...h.hslshlp..NpGsAFuhhsst......h.hhhhlslllhhhlhhh.hh+htp.......tthttlu.l....uLllGGAlG.N.llDRl.........hh...........................Gt......VlDFls.h......h.................hta.P..sFNlADsuIslGslll....llth.hh......tt.ppp	.....................................................................................hhlslll....ll.lDQhoK..hhlh.ppht.......................hs....................psh..........ll..s..s....h....hslshsp..NpG.....AA.F...S.....hLsst.............ph...hFh.hlslsls.l.h.lh...hh...hh.+p..tp......................pth..htlu..h.....uLl..lGGAl.GN.llDRl...........hp............................................Ga.VVDalph......h...........................hp.a..s.....lFNlADssIs...lGshllllth.hh.......pptt.......................	0	371	723	907
+3719	PF01640	Peptidase_C10		Peptidase C10 family	Bateman A	anon	Pfam-B_1522 (release 4.1)	Domain	This family represents just the active peptide part of these proteins. Residues 1-120 are not part of the model as they form the pro-peptide, which before cleavage blocks the active site from the substrate.  The catalytic residues of histidine and cysteine are brought close together at the active site by the folding of the active peptide.	21.80	21.80	21.80	22.00	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.78	0.71	-11.58	0.71	-4.53	53	317	2012-10-10 12:56:15	2003-04-07 12:59:11	12	11	122	17	47	318	19	176.30	29	29.83	CHANGED	WsQssPYNphsP..............stpssTGCVATAhAQlMpYacaPpp......uhGsh.sYpsstsp.........hphsh.....sposYsWssMhsshsp.........shspppt.cAVApLMtclGhAVpMpYsss...uSG.uhstp.shpALpphFsYsts.lphh...+sthssspWtshlhpELss..utPVhYsGsstss.....GHAFVhDGY....................scsuha...HhNWGWuGt.usGYap	..........................................................................WsQttPYN....t....hsP...................ttpshsGCVATAhAQlMta....ap..a....Ptp....t.tt...sht.t..t..........................ttt..asWsp...h...sshp...............sptpt..pslupLhtclG..hu..l..pM..pYs.s.........uSu..u...tt....s.ps.....Lpp........a.sYs.....ts..ht.h....+p.hs....t..pp....a....phl.h.p-Lpp...s..p..P...Vh.hs..Gsstss..................GHAaVhDGa............................................................................s.pps...hh........HhNaGWsG...ss.Gaa.................	0	18	39	47
+3720	PF03415	Peptidase_C11		Clostripain family	Bateman A	anon	MEROPS	Family	\N	25.80	25.80	26.00	29.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.47	0.70	-5.49	7	367	2012-10-03 02:24:44	2003-04-07 12:59:11	9	25	244	4	90	357	28	328.40	17	58.43	CHANGED	VahsuDN..sLptah.pDlpEMhpu.pss.....sllllhDth.....................hppsphh+lsccsph..ttl.sssth-hN.GDsssLcsalphhpspa-ADphhLlhWsHGsuah.csp...h.s+ulsaD-sN......tsplthsElpcsLp.....ts.plDlLuFDACLMGohEVhYplRs.....pADYlVASu...PG.GacY.phls.l..ssssss.....................plut.hV-pYt-.hssshh.........shoLSlaDhScl-tlhpslctlApsh................ss..pp.............shhsh......................................as.hspt.hsphsYpsLh-Lsphhpt.pphssthtth.ts...............................................................h....pshpphllYu..aG-hsst....shppuh...........oIaLPpssp..............shptahssasslt.....a.tchtWsc................l-pW	................................................................................ah.uss......sh..t...t.h...t..sltphh.t..s..htt.........t............plllhhst..........................................................t...thh.....h...p.t.t.t...h.........tth...hp...........p...s....s...s.s...ps....lpphlp....shp....a....PA.......c...p......YsLllhsHG............sGW..........h.....................s+..u.....h..s..hDpp.p......................................tt.t.hs..l..s.-lspulp.................sshph-hlhFDuChMuslEVAYpL+s......hscYllAS.s.sph.......u.......Ghs..Yp..p.hhstl..........s.s..ss..s..ht...........................................p.h..u.pthh.s.Y..t.s..h.s.sh.................................tho..l.olhDhsp.l....c.s.lt....phhcp.l.h..th.....................................................................................................................................................................................................................................................................................................................................................................................................htt.h........................................................................................................................................................................................................................	0	51	78	88
+3721	PF01088	Peptidase_C12	UCH; 	Ubiquitin carboxyl-terminal hydrolase, family 1	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.80	20.80	21.00	21.00	19.10	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.62	0.70	-5.16	72	1199	2012-10-10 12:56:15	2003-04-07 12:59:11	16	18	337	29	757	1143	15	189.70	30	64.44	CHANGED	sWhslESsP..sVhsphlppLGV..pshphp-lauL.Ds.....Lthl.pPlhullhLF.h.........hptppsttht...........tpt.sptlaFh+Q..sIsNACGThAllpslhN..sts.........lp.GstLspahchstsh.sP.ppRuphLpss....ctlcpsHsuhA.....ppu...........pspsst......pcs......saHFluaVs.....hsGpLYELD..Gh+p.tPls+Gtss.......scsalpcst...llp.chhp+h	................................ah.lEusP..tlhs.....ph....l.pphGl...pshphp...-lauL..-t..............p..lt.....l.......................pPlhul.....lhLF.ht.............................tt.........tt..t..p....tt....................h.......p..t..spslaFh+.Q..sIsNACuT......hA..............llpslhN........spt.......................l..p...G.s.tLpph.h..c......s..t..s..h....s.s.t.+uhhlp.ss...........p.tl...cp....sHsshA...ptt...............................................ppps...........cpcs...........saHFlual..............hsGpLaEL...............D..Gh......+....tP..ls.h..Gs.hs........pcshl.ptst....lhp.phh................................................................	0	230	382	594
+3722	PF01470	Peptidase_C15		Pyroglutamyl peptidase	Bateman A	anon	[1]	Domain	\N	22.70	22.70	22.70	22.70	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.15	0.71	-4.48	9	2041	2012-10-01 19:48:29	2003-04-07 12:59:11	12	13	1648	60	470	1259	104	185.10	39	88.92	CHANGED	hKlLlTGF-PFGs-slNPoh-ss+pLst.ppIusAplhuchlPssFpcut-sLpcslpch+PDlVIslG.AsGRotITsERVAlNlsDA.R..IPDN-GpQPlDcsIpsDGPsAYFoTLPlKAMspsl+csGlPAslSpoAGTaVCNalhYtshah.sppu.sl+uGFIHlPalP-QVlsK.tp.....PSMsL-s.ltGlpsAIcsuhct.	...................................................clLlT.G.Fs.PF.u.s.............c........p....l.....NPu........h....E..s....l...c...t.L.............s...................p...............p.......I...............s.............s........s.............p.........l.......h.....t..h.....pl......P............s..s.......F......t.c.u....h.........p.......h...l....p...p....t...l....p.......p.......h.......p.......P....D...........h...V...l...slGQA.G.G.Rs.s...l.TsE....R....VA...I....N....h..s..DA....R.......Is.D......Np......G...p.Q.P.l.Dp..s..I...h......-..G........s...s....A........Y..F........o.sLP........l..KA....hl...p..........sl.....p..............p..........p..........G....l..P.......u...........s..........l.............S..poAGT..aVCNalhYthh..a...h....h......p...p.........p.....h.........t....h.+.....uG....FlHlP.....a.hs.-.Q.s.h.s.+.s.s.t..........suMslpplhtul.phultsh...p....................................................................................	0	141	256	365
+3723	PF01831	Peptidase_C16		Peptidase C16 family	Bateman A	anon	MEROPS	Family	\N	20.20	20.20	20.40	20.20	16.80	19.10	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.58	0.70	-4.85	2	113	2012-10-10 12:56:15	2003-04-07 12:59:11	12	9	56	0	0	122	0	244.20	70	4.43	CHANGED	AFDAlhSEsLSAFYAVPSDETHFKVCGFYSPAIERTNCWLRSTLIVMQSLPLEFKDLtMQKLWLSYKAGYDQCFVDKLVKSsPKSIILPQGGYVADFAYFFLSQCSFKsaANWRCLcCsMELKLQGLDAhFFYGDVVSHMCKCGNSMTLLSADIPYThcFGVRDDKFCAFYTPRKVFRAACAVDVNDCHSMAVV-GKQIDGKVVTKF.GDKFDFMVGaGMTFSMSPFElAQLYGSCITPNVCFVKGDVI	..................s...................-.pahKVhGLYsPphTRsNCWLRSVLhVMQKLPhpFKDhslQcLWl.YKttYsQhF.VDpLVspIPtsIVlPQGGYVADFAYWFLo.C...DapshA.W+ClKCDhu.LKLpGLDAMFFYGDVVSHVCKCGpSMsLIssDlPaThHFuL+DchFCAFhT.RpVa+AACsVDVNDsHSMAVVDGKQIDs+hVTphouDKFDFIlGHGMSFSMooFEIAQLYGSCITPNVCFVKGDII..............................................	0	0	0	0
+3724	PF00648	Peptidase_C2	Cys_protease_2;	Calpain family cysteine protease	Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.30	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.94	0.70	-5.42	9	2514	2012-10-10 12:56:15	2003-04-07 12:59:11	16	97	332	30	1434	2331	90	246.30	28	35.47	CHANGED	LFpDPpFPssspSLtapphsP.....htlcWKRPsEIsssPpFIlGGAo......RT....DICQGsLGDCWLLAAIAsLTLN-cLLtRVlPtsQSFpEs.YAGIFHFQFWpaG-WV-VVlDDpLPT.+sGc..LlFsHSs-tsEFWSALLEKAYAKlpGsYEALsGGuToEuhEDFTGGlsEaaEL+cAPs...................................NLhc..IIt+hlc+ss.............LhGsShchsss.sshEshphptLV+GHAYSVTGsc-Vph....+Gph.pLlRlRNPWG.pVEWsGsWSDssspWs.lD.--+spLphphp.DGEFWMSFcDFlpaFoRLEICNLT	.....................................................................................................................................................................................W.hR.....s.....t.........c......h.......h......t......p................s........t........h.....h.......t..s.h.p...................t...........s..l..t..QG....l........G.c.....C.a....hl....u....u.l....u....s....l.............s....................p.................p.........h.................h......t..p.......l......h....................t....p................p..........h.............p......p..............p..................h.............G..h.......ap.......h...p.............h.....a.....p............G..p..W...............h.p.Vl.lD.D.h.L...P.............s......h............p.......s....p....................l......h...a.........s........p.........s..........t.p.....t......s......-....h........W.ss.L.lEK...AYA.K......l............t........G...........s..Y...........p......s.l..............p........u.G....p....s.........t.......c.....u...h........c.h......TG..s.....h..s....p.....h...t......h....p..p...s..................................................................................................................................................p.h.h.p......hh..t...p....h....h...p.ptp...............................................h.h.ss....s.h.....t........................t.............t...t....h...t...t...........u...L.......h..t...tH..AY..ul.h...s.h.p.p.......h.p.h...............................................p..Llcl.....+N.....PW...............G......p..................h.......c.....W...p....G........W......u.........-..t...........s...............p....W..........p.........................t.........p....t.......t......h.....................p...................t..................s.G.......F..W.....hs..hp-h.h.p.apth.......................................................................................................................................................	0	477	681	1105
+3725	PF01478	Peptidase_A24	Peptidase_C20; 	Type IV leader peptidase family	Bateman A, Yeats C	anon	Yeats C	Family	Peptidase A24, or the prepilin peptidase as it is also known, processes the N-terminus of the prepilins [1]. The processing is essential for the correct formation of the pseudopili of type IV bacterial protein secretion. The enzyme is found across eubacteria and archaea [2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.44	0.72	-3.88	103	5022	2012-10-02 13:41:03	2003-04-07 12:59:11	13	9	3530	2	1191	3816	981	108.60	23	49.30	CHANGED	llhhshLlhh..uhhDhcpthlPs.......tlsls.....hlhhullht.............h.h.shhshhttlhuu.........hssalhhhh.....................................................................................................hh.....................tht....uhGtGDhKLhuslGshhu.......httl...................hhhlllus.lhGslhsl	......................................................................................................h.hhhshllhh..uhhDhcp........th...l.P.s........tl.s...hs........hh.h.h.ullhs............................................h.h....hhs...h..h.s.s.lh.Gu..................hss..ah...hh..hh........................................................................................................................hh....................t.hp.........uhGhGDlKL...huul.....G...s...a.h.G...............hp.tl........................h.h.l..l.h.h.uu...lhuhlhh.h...............................................................	1	403	759	1005
+3726	PF03510	Peptidase_C24	Endoptase_C24; 	2C endopeptidase (C24) cysteine protease family	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	25.20	26.00	24.70	18.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.36	0.72	-3.86	5	118	2012-10-02 13:45:52	2003-04-07 12:59:11	9	6	60	0	0	131	0	103.30	42	5.21	CHANGED	GYuVHIGNGlYISlTHVAsussclhus-hKss+osGEhChl+ustIp.ousslGoGsPlpDspssPluTshpc+oasTTos+IsGhpsssso..pT+pGDCGLPYlD	.....GaslHIGsGlYlSssHVA+uus.h.spchhshp.ssu.-hChl+ustIt..SsAtl.u.pGpPVp.DshtuPlu.................TthtcKsaoToohKIsGhthsssT..pTppGDCGLPYhD.	0	0	0	0
+3727	PF01364	Peptidase_C25		Peptidase family C25	Bateman A, Griffiths-Jones SR	anon	Pfam-B_516 (release 3.0)	Domain	\N	20.00	20.00	20.00	20.10	19.20	19.90	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.57	0.70	-5.49	77	266	2012-10-03 02:24:44	2003-04-07 12:59:11	13	33	169	1	119	314	445	362.10	21	31.09	CHANGED	hlII....s..ssph.................hstsppLssa+psp......GhsstlVshpplhspas.............sG......sssu.........................IRsalchhasph.s..t...h.ph....llLhGDs................................tt...lPshps...................................................................................................................s.hsoDsaauhl-s...............................................scths-..lslGRlssposppspphlsKllsY-ps...t.....t...........W+pph..hhluss...................................................................................................hp..thtsthtthhst.h.sp+lahs..sh.ppss............................h..............lhpsls.p..GshlhsY..h.G......HGutssh........sstt.............l......shsshpshsNts....phPlhlshoCthupa.sss................ohuEthl......hsssuGAluhlusoc........hsh...................................sss.....spthspthhctlhts.t............p..............slGcshhtu+tphh............................................hsLlGDPulpl	.....................................................................................................................................lII....s....stph.............................hstspcLssa+ppp.......Ghpstllsspplhspas..................G....sstA.........................lRpal+hhaspt.s.......t.pY...llLhGDs.........................................thlsshts.............................................................................................................................sthso.Ds.aa...uhlcs...............................................ss.h.-...lslGRhsspos......p..-spshl.sKhlpYpps..........us................Wppph..hhhuss.....t........................t..............................................................................................................................................................................................hs....thspthtt.th.st....h.hp+lhhs..sh.ptss................................................lhpths.p........Gs.hlh.s.Y..h.G.............HGutsth..................uppp...............................l......shsc.hp.s..hsNts.........phPlhlos.sCthu...pFDtst....................ohuEthh...........hsspu...GAlAhhuooc.hsa...................................ssh...............spthspthhctlhsptts................slGcshphuppphhpt...............................................shhp......asLlGDPulph............................................	0	77	113	119
+3728	PF03785	Peptidase_C25_C		Peptidase family C25, C terminal ig-like domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_516 (release 3.0)	Domain	\N	20.80	20.80	20.90	21.40	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.39	0.72	-4.17	3	29	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	9	1	7	33	38	79.70	41	6.38	CHANGED	PTcMQVTAPAsIstosASasVuCDYNGAIATIScDGcMaGTAVVc.sGsATIsLTcuIT-EoNLTLTVVGYNKlTVIKsIpV	................Ppp.phThPApls.spuShslsss.sGuhssISpsGphaGouVsp.sGsATlNlT.slTs.pushslTlst.NhhsVIKsIps.........	0	7	7	7
+3729	PF03412	Peptidase_C39		Peptidase C39 family	Bateman A	anon	Bateman A	Family	Lantibiotic and non-lantibiotic bacteriocins are synthesised as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP-binding cassette (ABC) transporter. The ABC transporter is the maturation protease  and its proteolytic domain resides in the N-terminal part of the protein [1].  This peptidase domain is found in a wide range of ABC transporters, however the presumed catalytic cysteine and histidine are not conserved in all members of this family.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.43	0.71	-4.34	36	3484	2012-10-10 12:56:15	2003-04-07 12:59:11	10	38	1880	2	701	2968	283	127.90	24	22.09	CHANGED	+h.hlhQscppDCGlAsLuMlLpa..aGpphslscLRphttsstcGsohhuLhpsucphGhcspulpschs.hh....ppl.hPhIsah....phsHahVlhph....pcspllIsDP..uhGphplsppcFpppao.GhhLhhsssss	............................................................t...hh.Q.pt.-..CGh....AsL.shlh.pa.......a...G...p.......p....h........s.......h...t.........p.......L.........+...........c..........h.........h..........t........h............s............t..........p....G.....s.o....h.h....s.......l......h......c...s.A.c..p....l...G.h.....p....s+.s...l...p....h.shp....pl...........spl..s..h..Ps.Ilah......................phsH..asVl..hph.......................cps......p.....l....h..l..t..D.P......uhu.h...h.........p...h.s..h.pc.F..t.pta.....s.....Gh.h.lhh..t..s......................................................................	1	198	417	576
+3730	PF00770	Peptidase_C5		Adenovirus endoprotease	Bateman A	anon	Pfam-B_900 (release 2.1)	Domain	This family of adenovirus thiol endoproteases specifically cleave Gly-Ala peptides in viral precursor peptides.	20.90	20.90	21.20	21.50	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.46	0.71	-4.74	13	133	2012-10-10 12:56:15	2003-04-07 12:59:11	13	1	103	2	0	101	10	176.50	66	88.43	CHANGED	hFLGTFDKRFPGFlucsKhuCAIVNTAuRETGGlHWLAhAWpPpSpThYhFDPFGFSDp+LKQlYpFEYcuLL+RSALuuosDRClTLlKSTQoVQGPsSAACGLFCshFL+AFspaPssPMcpNPsMsLlsGVPNphhpsPps.ssL++NQptLYcFLpp+SsYFRpHpcpIccsTuFs+lp	...........YFLGTFDKRFPGFlu.scKlAC.AIVN..TAGRETGGVHWLAFuWNPRSpTCYhFDPFGFSDcRLKQIYpFEYEuLLRRSALA.o.sDRCloLEKSTQTVQGPpSAACGLFCCMFLHAFV+WPcpPM.DtNPTMsLLTGVPNuMLpSPpV.sTL+RNQEpLYcFLtpHSsYFRsHcspIc+sTAF-+h..........................................	1	0	0	0
+3731	PF03568	Peptidase_C50		Peptidase family C50	Griffiths-Jones SR	anon	MEROPS	Family	\N	25.80	25.80	25.90	26.50	24.70	25.50	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.13	0.70	-5.78	18	368	2012-10-03 02:24:44	2003-04-07 12:59:11	12	14	277	0	272	385	4	306.50	25	21.85	CHANGED	lphspssssL.....lloR..lssspsPhh.l+lPlp+hssp.ts.t.............................shcchccIlppsppss........pspps+ccWWpcRhtLDp+hppLlpslEcsalusapslh.s..h...psshpphspph.shLpptL.scpt..........hphsphlLclh.......................hhsthpcLhhhhlclLpapt.t........uhsEtchphhphhlc-slschppppspp......ppaslLVlDpplpphPWEslssLps.s.VoRlPSlphLhphhpppcsphp.th.hssp........................shYlLNPsuDLspTpccFcs..hFpphts.....WcGhhuphPop-phhcsLpssDlFlYhGHGuGtQYlpspslp+hpppusshLhGCSSstlt.pGp.hcstGshhpYlhAGsPhllGsLWDVTD+DI	...........................................................................................h....l.+...h.........hh..h.hsh..t..t........................................................hhtph.tl.p.t..s.............sttt+ttWWt.tR.t.LDp.phptll........tph-.p..hhu..sa.pslh..................t.......tth.ph..ltp...l.tpt.....................................................p..h.hp.h.........................................t.h..h.....hphht...........................................shs..t.p...h.............h.t..htt...h.t.t.................................tt.hhLllDpp..lp.h.hPWEshshhpt.....s...lsR..hP..Sl.t.hlhp..h....h..........p......t........t.................................................................................................................shallN.Ptu-.....LtpTp..p...php......hpp.............Wp.uhh.sp........Pst.p......p.......h.ptL..t..pp.....c...........lhl.YhGHGuGtpal.ps.pt.l...t.+.......h...........p...p......p......u....s......shLhGC....SSutlt.tG...........p..h-sh...............Gh.hpYhhAG.sPhllusLW-VTDpDI..................................................................................	0	103	169	235
+3732	PF03421	YopJ	Peptidase_C55; 	YopJ Serine/Threonine acetyltransferase	Bateman A, Mistry J	anon	Bateman A	Family	The Yersinia effector YopJ inhibits the innate immune response by blocking MAP kinase and NFkappaB signaling pathways.  YopJ is a serine/threonine acetyltransferase which regulates signalling pathways by blocking phosphorylation [1][2].  Specifically, YopJ has been shown to block phosphorylation of active site residues [3].  It has also been shown that YopJ acetyltransferase is activated by eukaryotic host cell inositol hexakisphosphate [4]. This family was previously incorrectly annotated in Pfam as being a peptidase family.	19.90	19.90	20.30	19.90	18.00	19.20	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.14	0.71	-4.41	17	290	2012-10-10 12:56:15	2003-04-07 12:59:11	11	1	201	0	29	190	4	171.80	37	54.49	CHANGED	spsLhpYuptshsplpsspt...s.shsphDlchLshLstshNpRhPsLNL+hacSsp-hhpulpp.......pssstuhRsllp.....hstsshH+sAlDl+.+.sG+solllhEPAsh.s.t......lsthsphtpphppphhspschshlEsphQ+S.s-ClhFuLshAl+uapcp.shhcplHcs.tpts	................................ctLpshhptlpsplhcGphh..phshpchDlchh..PhLVsptNp+aPp.........LNL+hhp..Ss.p-..h...spuIKp..............ht.puspStRhlls.....hss....sulHhsslDh+......h.....h.sG..Ks..SlIlhEPAshsshsss...............hLuhc.sc.....s..sh.-pp..p..L...P..cs.....hhuhlEhDIQRSso-CsIFSLuhAKKhhhEt.tshs+lH-cphp.t...................	0	2	8	16
+3733	PF03290	Peptidase_C57	Pox_I7L_G1L; 	Vaccinia virus I7 processing peptidase	Mifsud W	anon	Pfam-B_4082 (release 6.5)	Family	\N	21.00	21.00	21.20	281.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.35	0.70	-5.96	11	72	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	43	0	0	60	7	422.30	72	98.86	CHANGED	MDRYTDLVINKIPELGFTNLLsaIY..ShsGLshslDlSKFhTNCNGYVV-+a.DcSsTAGKVSCIPluhLLELVcpthL.......stPsstcp...ELslKctLl......spL+s+Ypshp-lhsLP..TSlPltYFFKPhL+EKVSKAlDFSQMDl+sDDL.S+tGlpsGE.NsKlV+lKIcPD+cAWMSNpSIpsLlu.hua.GoEVsYlGQFshpFLNshslaEKh-hFht+phLualL+DKI+....puppRYVMFGFCYhuHWKClI....aDKccphVsFYDSGGN.PsEFHHYcNFYFYSFSDGFNsNs..cs.SsLsNpNsDlDVLFRFFpssF.ss+hGCINVEVNQLLESECGMFISlFMllCshpPPKGFKulRKlYTaFKFLADKKhTLaKSILF.........Nhschsl-lccl-scul+EYpKME+WTpKuIssLssKIos+sNcIlN	M-RYTDLVISKIPELGFTNLLCHIY..SluGLCoNIDVSKFLTNCNGYVVEKY.DKSsTAGKVSCIPIuhhLELVESGaL.......S+.P.NSSD........EL-QKKELs......-ELKsRY+SIhDlFELP..TSIPLAYFFKP+LREKVSKAIDFSQMDLKIDDL.SRKGI+TGE.NsKVVKh..KIEPERGAWMSN+SI+NLVSQFAY.GSEVDYIGQFDMRFLNSl..AIHEKFDAFhNKHILSYILKDKIK....SSooRFVMFGFCYLSHWKCVI....YDK+psLVSFYDSGGNIPoEFHHYsNFYFYSFSDGFNTNc..++.SVLDNoNCDIDVLFRFFEsoF.GAKlGCINVEVNQLLESECGMFISLFMILCTpTPPKSFKSLKKlYTFFKFLADKKMTLFKSILF.........NLpDlSL-lsEoDNsGLKEYKRMEKWTKKSINVICDKlTTKlN+IVs..	0	0	0	0
+3734	PF00851	Peptidase_C6		Helper component proteinase	Bateman A	anon	Pfam-B_326 (release 3.0)	Family	This protein is found in genome polyproteins of potyviruses.	25.00	25.00	33.40	31.50	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.42	0.70	-5.86	19	1177	2012-10-10 12:56:15	2003-04-07 12:59:11	13	27	145	1	0	1300	0	409.10	47	19.54	CHANGED	pFapGaspsFhch+s.pshsHsCssshs.VcpCGclAAllsQulaPstKITCppChpphpshstcEhtphlpsphppthphhpsthspFsHlpphLchlppthpspNhNhpshtEIh+lls.spppuPFs+lpclNchLlKGspsosp-htpAoppLLElsRahKNRT-sIcpGuLpoFRNKlSuKAplNsuLhCDNQLD+NGNFlWGpRuYHAKRFFsNaF-plDPucGYs+YhlRcsPNGpRKLAIGsLIVstsLcphRpphpGcsIpp.sloppClSppsGNaVYPCCCVTh-DGpPhhSElhhPTKpHLVlGNoGDPKYlDLPpspsspMYIAK-GYCYlNIFLAMLVNVsEc-AKDFTKhVRDhllPcLGcWPThhDVATAChhLslFaP-spsAELPRILVDHsspTMHVlDSaGSLoTGYHlLKAsTVsQLIpFAsssL-SEMKaY+VG	..................................................................................................................................................................................................................................................................................................................FW+GaspsahphR..h.s.ps.H..p.C.t.s.s.ls.lcpCG.clAAlhspulhPChKITC.pCspchtphstp-.htphl.pp.phpphtp...p...hts.hs....cFt+....hhphLphhcp..h..h..psts..t..sh..phht-lhchls.phppssapplpclNphLlKG.s.ps.Tsp-hppAoppLLEluR..ahKNRp-slccGsl.psFRNKlSuKA.....plN.sLhCDNQLDpNG.NF....lWGpRt.YHAKRFFuNYFE.lDPscGYppa.hRhpPNGpRKLA.IGpLllPhshpphRcphpGc.lpp.sloppC.lSp.psssaVYsC.CCVTh-DGpshhS-lhsPTKpHLVIGNSGDsKYlDLPps.c.sppMYIAKcGYCYlNIFLAMLlNlsEp-AK-FTK.hVRDhlls.cLGpWPThhDlATsCh.LplaaP-stsAELPRILVDHpsphhHVlDSaGShooGYHlLKAsTVsQLIpFspssL-S-hKaY+VG......	0	0	0	0
+3735	PF01830	Peptidase_C7		Peptidase C7 family	Bateman A	anon	MEROPS	Family	\N	20.50	20.50	70.50	70.50	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.77	0.70	-5.22	14	61	2012-10-10 12:56:15	2003-04-07 12:59:11	13	3	5	0	0	57	0	157.40	65	35.17	CHANGED	MSCLRKPSQSLVLSESVD.....PTT.....VD..PFVDVRAEEVVPTGCMTLWEYRDSCGDVPGPLSHGDLRRLRTPD.GVCKCQIHFELP....TVLKSGSTGTVPEHPAVVAAFMGRPRRCSLEQRTKELDFRFLQLVHEGLPVRPSYMIARPPRPVRGLCSSRDGSLAQFGQGYCYLSAIVDSARWRVARTTGWCVRVAcYL+LLQWVGR+SFGSFQIEESAVEHVYHVI.......VDTEaQSEQDGALFYQAVSDLAARDP	.....................MSCLRcPSQuLVLstS.D.....Pso.....lD..PFsDVtsEEVVPpGChTLWEYRDSCGsVPGPLSHGDLh+L+TPD.GVC+CQIHFELP....TVL.......................................................................................................................................................................................	0	0	0	0
+3736	PF03569	Peptidase_C8		Peptidase family C8	Griffiths-Jones SR	anon	MEROPS	Family	\N	21.60	21.60	22.20	228.00	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.45	0.70	-5.03	2	18	2012-10-10 12:56:15	2003-04-07 12:59:11	8	4	4	0	0	20	0	161.60	79	15.59	CHANGED	hARuIGlSptustELVRsT+VsEsKPHLsPMpEAp.s.cQ.L.stRuh.Vssc.tslEls..clPscEGcCa.h.Fp.s.hT.hIhspKP..p-lluhhp.sssThDSL-Io+psthVHh.sG-sapsY+pIhAhLc.h.h.s.p.hlVGAcpspltDYVtAutpFLhp..pWl+NGL+lAtthhpPt.lhK..h.NsShP+sl.psD..YIp	LARAIGLSHsAsuELVRAT+VDEsKPHLVPMEEhKEAPRQQLVPRRSTFV-NHEEEVEVDsLRLPTEEGRCFELLFN.NQlTPAIFDKKPLLRDVL-VFEENVCThDSLEISHSD+CVHIVPGETFRNaKEIKAVL+VILWN-P-.ILVG...............................................................	0	0	0	0
+3737	PF01707	Peptidase_C9		Peptidase family C9	Bateman A	anon	[1]	Family	\N	25.00	25.00	115.50	114.60	22.30	20.00	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.34	0.71	-4.72	8	257	2012-10-10 12:56:15	2003-04-07 12:59:11	11	7	47	2	0	311	0	192.80	66	8.58	CHANGED	DPWIKsLTNsP+GNFTATlEEWQAEH-uIMpuIpspusssDsFQNKsNVCWAKuLlPVLcTAGIcLTsEQWsslh.sF+-D+AYSPElALN.ICTKaaGlDLDSGLFStPoVPLoYc.......ssHWDNpPGG+MYGaNppVAtpLp+RYPhlptthcoGcQlslspt+lpshsscsNllPlNRRLPHuLVspacppcuuchEphlsK	DPWIKTLpNsPKGNFpATIcEWcsEHsuIMAuIss+thohDsF.QNKANVCWAKuLVPlL-TAGI+LsccQWSpIl.AFKEDKAYSPEVALNEICTRhYGVDLDSGLFStPhVSlaYt.......sNHWDNRPGG+MaGFN.EsAshLER+YPFh+Gphsh...s+QlsVsTR+IcDasPssNllPsNRRLPHSLVsEH+ss+GpRhEWLVsK........	0	0	0	0
+3738	PF00413	Peptidase_M10	matrixin; 	Matrixin	Bateman A, Finn RD	anon	Prosite	Domain	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null --hand HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.42	0.71	-4.50	66	3213	2012-10-03 04:41:15	2003-04-07 12:59:11	19	158	1096	316	1273	3093	388	160.90	27	39.87	CHANGED	+W.p+.pp....LTYplhsho..sclspspVcpslc+AFpsW.ucV......oP.LpFpclt.......p...s....ADIhIsFs............pspHGDshP..FDGsuG.........sLAHAahPs..........hsGDsHFDsDE...pWThs...............................................................................................................................................................................spGhsLhhVAsHElGHuLGLsHSss.sAlMaPhYp.ht.p......pLspDDlpGIQpLYG	................................................................................................................................................................................................................................................................................................................................................................................h........tt.h....pp....shtpA.hp..h...W.sp.s.................ss..lp..Fppl.............p.tp..........ADI.h....l.t.Fh..............................p.t..t..c.....s......s.........s...............s......a.......-...u......s.s..........................hL..A+.A....ah..Ps..............h..tGss....H.a..-...t...s.c.......a.s.h.s...........................................................................................................................................................................................................p...s..h.s...L..h..h.VA...s...HElGHuLGL.s.H..........o...........s......s..................p........u...l...M.h.....P.h.hp..h..................tLtt-Dlpu..lptlY...........................................................................................................................................................................................	2	289	498	817
+3740	PF00675	Peptidase_M16	Insulinase;	Insulinase (Peptidase family M16)	Bateman A	anon	Pfam-B_88 (release 2.1)	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.58	0.71	-4.45	26	11461	2012-10-02 15:41:56	2003-04-07 12:59:11	15	55	4386	192	4038	9720	2217	136.00	20	22.38	CHANGED	pVsspps.ssspuslulhlssGSthEspp.sGlAHFLEHhhFpG.Tp+hss.ppltphlcphGGph....NAhTscEpTsYhhcshscs......lspul-hlu-hhtps...thscppl-c........Elptlcsch.....lhctlcssuaptpsLupslhsPt	.........................................................................................stht.lhh.t.s.Guh........t-...s.....t....t..p...........s........G...l.A.Hh.l..E.H.............hh..Fp............G......o.....p..p......h......s.....s....t....p.....ht..p.hl.p.p..h.G....u.p.h...........................NAhTu....h....-........p..TsY.h..h....p....s.........s..pp....................................lp..p..s.l.......p....lhs-...h....h..t.p..s...................t.h.s..p..p.p...l.........c..p...............tp.........t....h....h..h..t..E.h.p......h.psp..............h...t.....h.................t..........................................................................	1	1413	2529	3444
+3741	PF00883	Peptidase_M17		Cytosol aminopeptidase family, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_990 (release 3.0)	Domain	The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine  aminopeptidase.	25.00	25.00	25.00	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.89	0.70	-5.55	17	5342	2012-10-02 19:46:12	2003-04-07 12:59:11	16	21	3337	121	1482	3949	3549	304.00	41	63.96	CHANGED	lthuR-LhssPuNhlsPshhAcpApclupshu...lplpVlcpcphcchtMGuhLuVupGS..ppsPphlhlpYpsst.....cspphluLVGKGlTFDSGGhsIK..sussMctMKhDMuGAAuVhushpAluplchs.hsVhsllshsENh.SGsA.+PGDllsshsGKTlEVpNTDAEGRLlLADulsYApp.hssctlIDsATLTGAhslALGsshsGlaoss-pLtcplhpAuppuGEtlWRhPhp-c.YhcplcS.slADls..NhusttG..GuhTAAhFLppFlpp.....WhHlDIAGsshtpptt......GuoGhsVpTLsp	..............................................h..hsRDLsNtPsNh....hsPstlAp....p....A.....p....p.lspphu............lps...c.l.l...sp..cplcchG..hsuhh.....uVG+.G....S.....pp....sP....t....llhlc...............Ypsss...................t........ss...t......lsLVGKGl..TFD.................o.....GGlSlK......Pu.s..sMc.pMKhDMuGAAsVhGshps..lu.p.h.........p..L.....s.......lp....Vhullss.s...ENhsuGsA.............h+P................GDllTshs...........GpTVEVhNTDAE.G......RLVLADuLsY....Apc.....h............c........P..c......h....l....ID.....hA.TLTGAs...h.............lAL...G...p.c...h...sul....h....os....s....-....s..............L...s....p....p..l....htA...............u.ppss-..h..h..W..+L....P.....L.s.-..........p.....a....p.....c.p........l..c.........S...sh...A.D.ls........N..h.....u..u.p.t.s.........Gu......lTA......AtF......L.......p......c.......F.....s............c................p.....................................h.......sWsHl...DIAGsuhpssst.........tG.uTGhsVphLs.p........................................................................................................................	0	495	885	1213
+3742	PF01401	Peptidase_M2		Angiotensin-converting enzyme	Bateman A, Coates D	anon	Swiss-Prot	Family	Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.	19.40	19.40	19.50	19.50	18.70	19.30	hmmbuild  -o /dev/null HMM SEED	595	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-13.13	0.70	-6.32	6	802	2012-10-03 04:41:15	2003-04-07 12:59:11	13	14	230	68	446	817	299	468.30	35	85.85	CHANGED	DsshpssshssDEAtAphFsEpYspSApsVh.c.stAsWsasTNITsEsu+h..Ecuh.sppas.saGp+AKch.ss.aQNhT...l+RIItpVpsLspAsLPltchppYNplL.sMppIYSsupVCaPN..uoChsL-PDLTNlhAoSRpYscLLaAWEGW+DtVGhslhPhY.castlSNcAhR.sGaoDsGs.WRShYESPohEpDLE+LYQpLpPLYLNLHAYVRRALHR+YGscYINLcGPIPAHLLGNMWAQoWpNIYDhVVPFPstPNlDsTpsMlpQGWssp+MF+.A--FFTSLGLLPhPPEFWscSMLEKPTDGREVVCHASAWDFYNtKDFRIKQCTpVsMEpLssVHHEMGHIQYahQYKDLPVoLRcGANPGFHEAIGDVLALSVSTPcHLHpIsLLsp.ssshEpDINaLhKMAL-KIAFlPFuYLVDQWRWtVFsGphspppYN.-WW.LRhKYQGlCPPVsRspscFDsGAKFHIPussPYIRYFVSFllQFQFHEALC+tAGHpGPLHpCDIYQSpcAGt+LtsshphGhSRPW.EshKslsGpsshsApAhLsYFpPlopWLpppNpRpGEsLGWPEYpWpP	...........................................................................................................................................................................................................................................................................h..hht..p.....h.......utW..ts.ls.t....s..................t..h..t.......t.t.h....................t....p....s.t.t..h..............hps.p.......h+..p.....hthl..t........t.....s...s.l........s......t.c......t..ph...t....pl....h..s...p...Mpt......hYutu...ph.C..........p......................tp.C......h......Lp.....P......p...lpp.....lh...s......pS+.......sh..........pchhasWpuW+ptsG..h.....h....+s.a.chV.t...LtNc..sAp....s.................satsh.uth.W.....p..t....Y.....-......................s..........p..........h...........pp.....l-.pla......p.....plpPLY.....pLHuYVRtpLhptY..G...p..h.l...s........p.G..s.lPAH....L....L.....Gs.MWuptWs..sl...hsh.hhP..................a.s..t.t..s..t.h..D..l.o..........t...t..h.hp..p.s.a.ss.......chap.u-pFFhSlGh......hs....pFW.ppS...hh..p.c....PtD...R..cl..lCH.s.o.A.WDhh.......t........t.....t.........D.......h..R.....IK.Cs..p...ls.h-...phhshHHEhGHlpY...ht...Y..p..p...Ph..hh+pGA.NsGFHEAlG-hhuLSssTPp.......aLp.p.lGLL..p.p........................t...s......................c..............t..p.........IN.......h.L...hp...ALppl.shlPFsh.hh-pWRWtVF.pGp....ls...p..p....aNptWW.ph..+.catG...l.hsP..l...Rs.p.p...hDsuuKaH..lss.s.hs.a.h..............RY..ahuhlhQFQFacuLCpt........u........t.........p.......p.......s...........P.......L......ap.CD.lh...t.sp...tAGph.Lt.phh.phGtSp.....sW.psh.............p.hs..G..p..p...p.......hsspsl..hpYFpPLhpWLpp.pNt.....hGW................................	0	164	207	346
+3743	PF00557	Peptidase_M24	pep_M24; 	Metallopeptidase family M24	Bateman A	anon	SCOP	Domain	This family contains metallopeptidases.  It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3].	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.78	0.70	-4.75	656	20523	2009-01-15 18:05:59	2003-04-07 12:59:11	19	77	5099	201	5995	15852	9743	218.60	23	58.35	CHANGED	pth+pAsplsspshp.th....h..t.......lc...s...........................G.........................h.........o..-t-lsshlp...h......h...tp.......t..u...........tpth..........ua.....s...sllssG.sss...h..........sHh...hs..........s.tpt................l....pp....G.................................-l..lhlDhGsph.....GYtuDhoRTh....h..h.......G................s.....t.......cp.la.......phlhcup...p........tul.p.tl.+....P.G.....s...........p..hs-lsptspphlp..p.......h......G.h...................................thhh+.......thG.H........GlG......l.plH...tt..............................P......h............l.....s........................................................tt......tth.........Lc.....sGMlhol.EP.................Gha..........h.s.....................................................sh..........................................................................h.Gl+lE-......sllloc	.....................................................................................................hh+pAsplss.pshp.th...h.....ph..........lc.........s...........................G.................................h..............o.....ph-...l..s..thhc...ph........h.........pp.................tu..........................hsth.....ua..........s...shlss..u..hN.ss........l...................sHh.....hs....................s..sph...........................l.......cp.......G.................................-l.......l.h.l..Dh..G..s...h...hs..............G.atuDhoRTh...h......l............G..........p.ss.....p.................................tcc.lh...............p.h..s....h....c....uh...................tul....p...th....+.................P...G........s................................p......ht-.l...stthpphhp..p...............t.............G.h...................................................thhtc........hsG.H....GlG............h...ph.H.....-t............................................P.......l.............................................................................t....pshh.....Lc................GM.....lho...l..EP....................ulh............s...........................sh...................................................................................................t.usphEc...slllT..........................................................................................................................................................	1	2007	3696	5023
+3744	PF01742	Peptidase_M27		Clostridial neurotoxin zinc protease	Bateman A	anon	Pfam-B_407 (release 4.2)	Family	These toxins are zinc proteases that block neurotransmitter release by proteolytic cleavage of synaptic proteins such as synaptobrevins, syntaxin and SNAP-25.	20.10	20.10	20.40	20.60	19.20	20.00	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.48	0.70	-5.61	13	216	2012-10-03 04:41:15	2003-04-07 12:59:11	12	5	34	118	5	238	0	366.70	42	32.95	CHANGED	hsIN.sFNYsDPVsNcsIlhl+...sctsspaaKAFcIssNIWllPERa.aGpsPs...hstssplpuh.s.uYYDPNYLoTDsEKDcFLpshIKLFpRINssssGcpLLshIssAIPahGs............................spT..spFssspcosslshK..p....sspshhhsNLlIFGPGssIl-ssshshp.......sppsucpGFGoht.lpFsPcasasFsss...........p.FhsDPALpLhHELIHuLHtLYGIK.ssshplh.ppps.ahstpts.lphEElhTFGGpDhplIssssppplhshhLssa+sIAp+LNplpos.sss..h.lspYKphacpKYphsp-ssGpasVNlsKFsclYppL...aTEpshustaplpsRppYashcYh.hph.slLssslYsIp-GFNluphshplshsGQNtplNs	.....hpIN.sFNhssPVDNcsllhl+...sctsspaaKAFcltsNIWlhPERa.aGps.p...hscs.phcs....uhYDssaLsTssEKDpFLpshIK.LhpRINssshGcpLLphIssuIPa.hs............................pps..tpatthhposhls.p.......sspphhhsNllIhGPGssIh-spsh.ht........p.sucpGhGoht.lhFpP.hsatasp..............FhhDPAlpLh+pLI+uLahLYGIK.sssh.l.hp.ps.h.p.phs.lph.-hhs.GGpDhphIsss....h.shhhssh+shtpphNchpspltss....hN.hK.hhcpKath..sspshaslslshFsc.ap.l....h.p.phspthphhpRppYa.hsas..........c.YsI.pGFs.sphNhplshpspNpsI.s.........................	0	2	5	5
+3745	PF02073	Peptidase_M29		Thermophilic metalloprotease (M29)	Mian N, Bateman A	anon	IPR000787	Family	\N	21.50	21.50	21.60	21.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.29	0.70	-5.70	73	2095	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	1554	6	468	1517	492	367.30	34	92.86	CHANGED	M....hcpplc+aAcllV.....chGlslQtGpplllpus.hc.stchs+hlsccAYctGAtpVhlpas......DsplsRhhhpt.usc-p..hc..phPpach...pphhccssuhlulhu.pssshLssl-sc+luthp+At.sts.hcthhpth.tsthsWslsshPotuWAp.h.....psp.ul-phh-hlFcss+lDtt.sPltsWcp+scplpphschLNcpph.pL+ap.us.....GTDLolplscp+hWtuust.sp.....hhsNhPotEVFTuPhcpsVsGhVpsspPLsapGsll-shpLsFccGclV-hsA..cpGc-hLpcll-TD-GA+hLGElALlsssu....hshhhaNTLFDEN.....uSsHlAlGpAYstsltsG.t.........tGhNcShlHlDhhlu........usclplDG...tsp..slh+sGsa	..............................................................................................................................................................................hcppLc+hAclll.....phGl.s.lQ.Gpplhl.....pss.....lp.thtL.s.+hlsccAYp.hGAt.Vh.lpap......Dpt.lp+.hh.tus..-p..hp.........phspach.t...t.t.h.h.cp..t..s..uhlulhu......psP.....shhssl-..s.....p+ltthp.psh.utu..hc......hhpthttsphsWslsuhP.s.tWAp.las........ssctuhp.thh-tlFc.ssR.l.s....t..sPl.t.sWcpHsptL....pphsc.hLNc.pphttLH.as...us........G...TDLTluLs..c..p..+..h..W.p.s.us.s.hsstt.......hhsN...h.P.....T.....EEVFTuPspp.........p....ls......GhVs..s....s...p..P..Ls...Y..s.G..s..l.I...-.s..hplpF..c..cGcIV..-hsA................cp.G..c....c...hL......c.c..l.............l............p..s..D......E.............G.............A....+h.L...GElALVsssSP.....Iuppsh.....h.Fa.....N....TLFD......EN.....AosHlAlGs...AY..s.......h.......s......h............s......G.t.......p..h.......s.......c..p..........h.......t...tGhN.p.S....................l............HhDaMlG............osch.s.lDGh.tsGp...lh+sGpa.....................................................................	0	181	345	417
+3746	PF01432	Peptidase_M3		Peptidase family M3	Bateman A	anon	Swissprot	Family	This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence.	19.80	19.80	20.00	19.80	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.57	0.70	-5.45	29	8043	2012-10-03 04:41:15	2003-04-07 12:59:11	15	23	4148	12	2004	6381	1947	390.10	24	63.94	CHANGED	hhhpspscplR+psapAhhpphtp.t.....h..stllpchlph+......AclhsasoatphsLts.hspsspsVhsFLtclhpcttPhhcc.hphhpphh.tt.......hshp...clpsWDh...........as......lspp.hp.aFsh.ppslp..................................tpsapp..............ptshhuphalDhasRcu.KtuG..Aashshhst...............................................shshllhNasp.................shs-l.pTLFHEhGHuhHshhoppp.shhssh.sss.....h-hsElsSph.Ethhh-hthhthhs..chpstts...................l.pchlpphh........h.thhRQlhhuth-hplHpttp.st..s...h.c..atplppchhs..hssss.......sp.th.s....ths.l.....thYsusYYsYhaupsh..usshapphhc.s...s.........chhpphLptGGStsPh-hlcphtsc.spscshhcshsh	...............................................................................................................................................hh.spspplRcphapuhh.pthp......p.......................t..............p.........h...sthh.pphl.ph.+tth.....................Ap...lhGap...s...h.t.....p...h.....t...L..t...s.............s...ps...s...pp....l..h..s.h.L...p.l.h.p.p.t....h....sh...h.p.c...ht.hpp...................................hGhp.......plp..aDh............................as..................hsp.tt.h.c......h.hsh.pp.....s.hp...............hhh..t.h...sh.........................a..p..........................................................ptth..............sphal..Dha.............s+..p..u....K....pu.G....Aahs.shhst..............................................................................s.hsa..l......l...h...Nast.....................................................shs-............l.hTL.hHEhGHuhH.p.h...h.o..p..p.p......s..h..sss...sss.................hshsEhsSph.....Eth....h.hc....h.....h.p.h.h........c..h.c...p..t.t..s................................................................l..pp.hl...c..p.hh.................................h.thh.cpl..h.u..hF.-hpl..Hpt.........pt....s.t..............t.............lsp..hhtp..lpp...ch..hs........sh..............................s.p..thsh.........tau+l..............thY..t..s..s..a..Y..s.........Y..h..a..u..p..sh.......ussh.a.p..t....hh..c....p.u.....s.........................h.......ch...h.p...hL.p.t.GuSp.p.s.h-.l.h.c.t.h.t.s.c..sp.cshhpt...h.........................................................................................................................................	1	652	1241	1669
+3747	PF02074	Peptidase_M32		Carboxypeptidase Taq (M32) metallopeptidase	Mian N, Bateman A	anon	IPR001333	Family	\N	19.90	19.90	19.90	19.90	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	494	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.46	0.70	-5.87	3	1205	2012-10-03 04:41:15	2003-04-07 12:59:11	10	5	1118	17	345	1078	910	472.10	36	95.91	CHANGED	MphcsshKElL-hhRRIuaLGcAsALhuWDpRTshPKcGpt-RAcuhGpLSsLlaEltTcPRhsELlEKlcGp..hEDLsEDs+ssVRlh+RpYEcsKuIPEchhKElupssSKAETAWEEAKuKDDFStFpPYL-+LIuLAKR...hlpYlG.YpE-P.....YDALLDLYEPGlRsRDL-pLFcELccuL+PLL-+ILuSG++PDsusLcK.+YPKEtQ+cluLalLQchGYDL-u.GRLDsTAHPFsTslGhGDVRITTRY-EcDFRsAIFGTIHEhGHALYEQslDEAahGTPlu-GASLGIHESQSRFWENlIGRSKcFWEhaYP+lKEsh.sphcDloLEDFahAlNtV+PSFIRVEADEVTYNLHILlRaELE+AlFSsEVplEDLPEhWN-KYccYLGIsP+TY+EGILQDVHWAGGsFGYFPTYoLGslYAAQLatKhpEDLP-FEsLlARGEFcPIKsWLREKIHtaGSRa+P+-LlK+ATGE-lNAcYFlRYLcsKY	.........................................................................h.......pphh.phhcc...lp.t...hp.phhulhtWD.pT.hMP..p.tG.s..ptRu-shuhLush....haphhT....s....sp....hs....ch....lp..ph...c..pp..............p..p.....L....s.........p.....h......p.....p....t....slcc.....h++p..a.ppsptlPtphhpthsthsucucpsWcp.A.Rt.p.s.Das.tFtPhLpcllchp+c.......hhph.h..u....h.t..p..s..s.........................YDsLL-.YEPGhTsppL-plFspL+....ptlssLl....p.pl.hp.p.....t.....p....p........p...s...s..h..lp.t...p............as.......tcpQ.cphsh..pl.h.c.hl.GaD.Fsp.....GRL.Dp.osHPF.ssu.ls...s.DVRITTRY.sEs.-FhpulhuslHEsGHAhYEQ...s.l...s...c...p...ht....s.o.P.l.....u.........putSMGlHESQSLFaE..lGRSpuFhphhhsh.hpcth....sph..s...s..h.....s.h..-..shacthscV.c.su.h.IR.l-ADElTYs..hHlllRYElE+tLhsG...plpVp...DLPphWNcKhpp..Y.LGl.p.s.p.s.c.tp..GsLQ...DlHWosGsF.G.YFPoYsLGshYAAQhhpshpcsls...........s........l..-s..hl.tp..G-.hsslhpWLpcpIapaGsh.h.s.s.p.-Llpcu.T.G.E.s.LNspahhcaLcp+Y...............................................................................................................................................	1	111	208	279
+3748	PF02102	Peptidase_M35		Deuterolysin metalloprotease (M35) family	Mian N, Bateman A	anon	IPR001384	Family	\N	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.12	0.70	-5.80	4	234	2012-10-03 04:41:15	2003-04-07 12:59:11	10	2	67	1	138	280	1	281.40	31	91.47	CHANGED	MRhTsLuoAlLALAssslAhPspos.uPsLDVoLoQVDNTRIKAVVKNTGuEcVTFVHLNFF+DuAPVKKVSlaRp..................ssEV.FpGIKRRhpopGLoc-uLToLusGEolEDEFDIAoToDLopGGslTIRocGFVPIssDsKlTGYlPYpSN-LplpVDuAKAAsVspAlK.LDRRTKVssCsGoRpSALoTALpNsspLANtAAoAApSGSuS+FpEYFKTTSppsRosVAuRhRAVA+EAuSsSSGSTTYYCsDsYGYC-oNVLAYTLPupNlIANCDIYYSYLPALspoCHAQDQATTTLHEFTHAPGVYSPGTDDLGYGYcAATuLSuSQAL.NADoYALaAN.......ulclKC	.............................................................................................................................................................................................................................lpl....p.....l.......................t.t.......hps.lpNtutp..hp.hhp.h.t...h..s.t....spph.l..t.t..............................t.t..h..FtGhh...h...ttl.........p..h..l.sttohp.......hs.hA.h.ph..t....t.....h..h...........t...s.......h....h..h.............t...........................s.......h.......h...ss..ht...h.t.s.............s.................................h..................................t........c.Rs..p......h..s..s.......C.s.s.s.ptstl.psALpssupLAptAtp...A...s..p...s...t.s....s...phappaFKoss...sphp.phVtspF.ptlupEs.sps.s.sups.ohhCpD..s.h.s...h..C....p.....s.....s........s..lAYT.....l..s.s.......p..s.....ls..C.Pha.....as....p..hP..s..h......o.ppC...p...u..t...D.......Qs.T....ohLHE.hoHh.thh.......tsp...Dh..u.YG.apssppL...su...s...p...ulpNADoYulFAps............hhht....................................	0	38	76	114
+3749	PF02128	Peptidase_M36		Fungalysin metallopeptidase (M36)	Mian N, Bateman A	anon	IPR001842	Family	\N	23.30	23.30	23.30	24.00	23.00	22.90	hmmbuild  -o /dev/null --hand HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.28	0.70	-5.62	31	458	2012-10-03 04:41:15	2003-04-07 12:59:11	10	28	290	0	202	440	80	321.30	31	49.08	CHANGED	AsYpVYPaslssPsc.......GsRsllssP.hss..hASPauWpsssss...paTs...TRGNNshA.ps..ssussth.....sshpPsu.....ssLpFs.aPashshs.Ps.........sahsA.ulTpLFYhsNlhHDlhYphGFsEtuGNFQhNNhGpGGtGsDhVlspAQDGSG..................hNNANFuTPPDGpssRMpMYlWstss.................................................................................................................................................................PpRDGsF-uGIllHEYsHGlSNRLoGGPuNosCLss.p............ouuMGEGWuDahuhslplKsuDTtssshshGsasssps...sGIRsasYSTshshNPhTYssl.......sshsss........HulGsVWAohLaElhWsLIDcaGhss.....sha.........tsG.....GpplAMpLVlDGMtLQPCNPsFlpuRDAILsADhslssGtNp.......CpIWcuFA+RGLGhuAp	........................................................................................................................................................................t.........................................................................................................................................................................................................................................................................................................................................shp.....................u...........ttD.h.h...s....ts..................hN.NAshtss...s.D...GpsschphY.hsttt..........................................................................................................................................................................s.hD..suh..-AuIlhHEYsHulps+hssG.uss...t.t...p................uGuMGEGauDahAs.sh.ph.................p......ss....s.p.......t.......t..s.......s.......h.......s....h..Gp.......ass.....s..........s.....................s..........s..lR...p.h....sh........ss.......p........s..N..s........hsa.ssh...............pths.pl...................HshG....plWushLa-hhhshlp......p.h.Ghs...............s.h...........................................Gp.lhhpllhpuh.h....ss.......s.spFhpu+cAIhpADthh...hs.....Gtpt........s.l.chaAtRGlu....h...........................................................	0	108	146	176
+3750	PF01447	Peptidase_M4		Thermolysin metallopeptidase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Psiblast P06142	Domain	\N	22.20	22.20	22.20	23.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.20	0.71	-4.10	13	1948	2012-10-03 04:41:15	2003-04-07 12:59:11	13	69	1073	112	314	1608	50	143.00	32	26.78	CHANGED	sssstsGctVhGc......tp.lsls+sust..ahLpDsTctss..lpoYsussp........hohsuo.......lhpssssshs.....s.tuuuVDAHaaAthlYDYY+shasRsSlD...spGhplpSpVHY.....G..ssYNNAaWsGspMlYGDGDs...sFhPLSuslDVVuHElTHGVTEp	.......................................................................s...thGh..h.st........sht.hst.sst........a.h..-.s.p...t....t....h............................tshshppt.................sh..st..................hh.p.sp.spshs.........tps...susD.Aa...a.h.u.stsa.Da.Y+...sh.asRsSlD.......spGhtlhShV...Hh..........u.....ps..a..s.NA..F......W.......s..G.....s...p..M..saGD.G..-s...............h..Fh.slsuulDVsuHEloHGVTp.............	0	95	182	266
+3751	PF03410	Peptidase_M44	Protein_G1; 	Protein G1	Finn RD	anon	Pfam-B_4417 (release 6.6)	Family	Protein G1, named after the vaccinia virus protein, is a glycoprotein expressed by many Poxviridae.	25.00	25.00	131.40	131.30	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	590	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-13.06	0.70	-6.26	3	79	2012-10-02 15:41:56	2003-04-07 12:59:11	8	2	49	0	0	69	0	519.90	70	99.81	CHANGED	MIVL-NGVRVFINsuMsKDIYlGlSNFGFENDIsEILGIAHLLEHILISFDuTRFVANASTARSYMSFWC+uIRuc.TplDAlRTLVSWFFu+GuLKDDFSlS+IRaHIKELENEYYFRNEVFHCMDILTFLuGGDLYNGGRLSMLDpL-sVR-lLscRMRRIuGPNVVIFVRELuPusLuLLspTFGoLPACPpTIPuTlhsSIsGKsVMsPSPFYTVMV+V-PTL-NILuILCLYEoYHLVDYETlGN+LYVTFSFIHEpDYEuFLRGsGcLplo.spRIcLNYSDDYlMNlYLNFPWLpHDLaDYLTplNsDosSlLpSLEc-IYpSVRsRDlIVVYPNFSsoMsNTRDRQpH+lVVLDs.NluhuupPsRSIcLMKRQT+NElFIRYGDAuLlDYVsLALu+.RchuL+Rps+GIRl+HuFSADDI+sIMESDTFlKYSRSKPAAMYQYIFLSFFASGNSI-DILp+RESlVcF.uR+sKNKIVFGKpARYDVsTKSSFVCGIlRGPpLocsuLT-hMW-LKRKGLIYSLEFTcLhuKNTFYLFsFTIYPE-VYcYLuopKLFSu+ClVVSpKG-sEDFSSLKKDVVI+l	.............MIVLPNKVRIFINDcMKKDIYLGISNFGFENDI.DEILGIAHLLEHLLISFDSTpFLANASTSRSYMSFWCKSIput.opsDAIRTLlSWFFs.N.G.KLKDNFSlSsIRhHIKELENEYYFRNEVFHCMDlLTFLuGGDLYNGGRIsMl-NLshVccMLsNRMpRISGsNIVIFVKcLssuTLshhppTFGoLPuCPElIPss.hs.sossGKIVMhPSPFYTVMV+lsPTLDNILuILhLYEsYHLIDYETIGNQLYlTlSFIDEo-YEuFLRG.ul....LplupsppIs.hNY.oDDYhMNIYLNFPWLuHDlaDYITcIN-cocslLhSLps-IYsSIlsRDhIVIYPNFSKuhhNocDsQpH.IVVL..................Ds.....sN.....c..s..hh.....+........+...P.......h.....psIs...........LMK+.h..T.s.NEIaIRYGDASLhDhlTL...uLSh....pDhsL...+..RssEGIRl+HsFSADDIpAIMESDoFLKYS+SKPAAMYQYIFLSFFASGNSI-DILsNR-ST.Lch.uK+s.KsKILFGRNTRYDlssKSSFVCGIV+GKsLccsoLs-hMW-LKKKGLIYSMEFTsLhSKNTFYlFsFTIYsDEVYcYLsssKhFou+CLVVSsK...G...-lEsFSSLKKDVVIRl...........	0	0	0	0
+3752	PF01427	Peptidase_M15	Peptidase_M45; 	D-ala-D-ala dipeptidase	Bateman A	anon	Psiblast Q47749	Family	\N	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.35	0.71	-4.70	5	2743	2012-10-02 01:02:30	2003-04-07 12:59:11	12	9	1142	6	295	2325	328	113.20	39	86.22	CHANGED	cssGhlsLcpllsDlchDuKYATtDNFTGK..shYpssRsLucc-sApuLtcApulAsspGhsLllWDuYRP+sApsshhtWsAsPEsshst-sthssIp+sth.s...suopSoHSRGoAIDLTLh+sDpGpLVDMGocFD-McERSHssAsu.VussuspNR+..........pLRuIMEuuGFpuYSuEWWHFcLsDps....Yscsah-FsVs	........................................................................................................................FTG+..l.............ssY.....s...sR.hlhp.csh..s...sALtpA.pp..p..A..p..s............G..as.Llla.DuY....R.P.QpAs....p......t........h......h......t.....W.......s.......t......p..........P....................................................................................................................................................................................................................................................................................................................................................................................................................................	0	109	194	256
+3753	PF01435	Peptidase_M48		Peptidase family M48	Bateman A	anon	Swiss-Prot	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null --hand HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.52	0.70	-4.79	21	10571	2012-10-03 04:41:15	2003-04-07 12:59:11	13	115	3867	4	3276	8591	3845	215.40	20	61.15	CHANGED	hhhlhsshhhhphst.hhtplhtph............stppsplcphlpclApps....sh.....hclhVlcssp...............sNAFshstup....lslpsuLl....pt......................................hscsELtAVlGHElGHhttpHshhp..hhhuhhhslhhhhshshhhs.thh.tttt.......................hlhthhhhshSRppEhpADthuhph........hhpshhp.t..........hshhtplpp.......................................ttssssshhsthhpTHPshspRlpt	.........................................................................................................ht.................................t................................t...t.......l.h...p...h..s.p....p...l...spps..............s..h.s...............p..l...h..l..h.p..s.sp............................hNA........F......A......h.......s......s.....s..........p...........................l.s.l.psG..Ll.....pt.............................................................................................hsc..s..E..l.tuV.luHEluHlt..ptchhpt...........h.h.......t....s...h......h...s............s....h......h....h......h.........h.......s........t.........h......h..........h.........h.......h.....h......s........t......h.....t.........t..s....t............................................................................................................hhs.t.h..h....h..t.h...S...R...p....p.E..hpADthuhpl...........hhpuhhp.psh.................................phh..p.p...h.tt.......................................................................................h....t....s......t....t...h.......s....p.......h....h...t......o..HPs.ppRlt...........................................................................................................................	1	1028	2092	2791
+3754	PF03571	Peptidase_M49		Peptidase family M49	Griffiths-Jones SR	anon	MEROPS	Family	\N	19.10	19.10	19.20	19.20	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	551	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.95	0.70	-6.44	27	706	2009-09-11 00:19:35	2003-04-07 12:59:11	10	9	421	5	366	722	86	347.00	24	67.47	CHANGED	spl.appspch............lYshcsptt..LGa.spsshosYYs..........sslocp-h-hls.chhpspsl...s.NTRlhK....sucs......aplhlASsppsppst.h..............phpGpp..lplshGDast.hp+lsppLcpAppaAAN-sQpcMLctYlcpFpoGshpsHKcuQ+hWlKDhuPhVET.IGFIETYRDPtGlRuEaEGFVAhVNK-pot+FspLVssApphlphLPWsps..........aEKDpFh.PDFTSL-VLoFuuSGlPuGINIPNYDDlRps.GFKNVSLGNVLuusspspp.....lsFls-cDpclapKapspuFEVQVGLHELLGHGoGKLhpcstsGpaNFDhps..ls.lssc..l...soaYcsGETWsShFGsluuuaEECRAEsVulYLshpc..-lLcIFGhpssp.....-tccllassaLpMlcuGL.huLEaasPcsc....KWsQAHhQARFsIl+slLc..tspshlclppsp.sp...hsslplclD+S+I..osG+pAlpcaLt+LplYKSTu-hcsGpchaschosVs-p....ahchR-lVlt..+KpPR+halQuNThlss........spVp.lh-Y-po.tGhIpSalER..	...............................................................................................t.............................................................................................................................................................................h.h........G...a.t..htphs..lppAtt...hutsttptthlt.hhp.atpGs.ptacp.phhWl.pphss.l-.......GFhEsYtDP.h.G.h+.upaEu.hlth.....hs........t.ottht.hs..tput.h....Phs.t..............ac+..p..h.....t..s..shpslps..h...h..h...uu.....s..........h.....P....h....GI.....NlP...............N.........p.lRtp.G.Ks..VpltNlhtsh..t...........h.l.p.....t.....t..p......th.h..p.h.t....s..lp...sshHEh.hGHGsGpl......................................................................................................................................................................................................................................................................................................................................................................................s....................................................................................................................................................	1	147	232	311
+3755	PF02868	Peptidase_M4_C		Thermolysin metallopeptidase, alpha-helical domain	Bateman A, Griffiths-Jones SR	anon	Psiblast P06142	Domain	\N	24.40	24.40	24.70	24.40	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.14	0.71	-4.50	113	1990	2012-10-03 04:41:15	2003-04-07 12:59:11	10	77	1088	114	328	1719	59	152.70	37	28.88	CHANGED	usLhYpspSGALNEuhSDlhGshlc.ahttt.........t......t..........DWllG--lhp........t...G..suLRpMssPsps.........sspssphs........sh.....................tD.....sssVHhNSGlhN+AFYLlupu...........................hsGhuhcKAtcIaYcAhsh.YhTsso....sFspu+suslpAApDL...aGttu..tphpsVpsAassVGV	...........................................usL.YpspSGALNEuhSD...lhGhhlc.a..tt...................t...............sWhlG-.-lht.................t.u....suLRsMpsPsp.................tsps..schsca..................................ttDsGGVHhNSGI.N+AhYLlupu.............................t.u.l.GpcKs....tpIaYpA.s....Y....ho...s..so....sF.......pps...+suslpuA..p..-L........YG........s.......tpspsVtpAassVGl...............................................	0	104	192	278
+3756	PF04951	Peptidase_M55		D-aminopeptidase	Bateman A, Rawlings ND	anon	COG2362	Family	Bacillus subtilis DppA is a binuclear zinc-dependent, D-specific aminopeptidase. The structure reveals that DppA is a new example of a 'self-compartmentalising protease', a family of proteolytic complexes. Proteasomes are the most extensively studied representatives of this family. The DppA enzyme is composed of identical 30 kDa subunits organised in a decamer with 52 point-group symmetry. A 20 A wide channel runs through the complex, giving access to a central chamber holding the active sites. The structure shows DppA to be a prototype of a new family of metalloaminopeptidases characterised by the SXDXEG key sequence [1]. The only known substrates are D-ala-D-ala and D-ala-gly-gly.	25.00	25.00	33.80	31.10	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.55	0.70	-5.18	41	469	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	424	5	164	444	48	259.60	34	95.97	CHANGED	MKlaISsDhEGlsGlsshpplps.......usspYp+uRclMTp.......EsNssl-uAhpuGA....s-VlVNDSHusMsNL...lh-clcs.....cspL.lpG.ps+shuMhpGl.-puhDushFlGYHu+AGs.p.GlhuHThsutshpplhlNGptlG.EhslNAhlAGtaGVPVsLluGDDh.htpEs..cthhP.ssphlslKcuhu+huuhshosppspptl+puscpAl..cptpph.....pshphssPsplclchpssuhA-hsshhPslERl-usT.Vcapupshh-shpshpsl	........................................MKlaISsDhEGluGls.s.hppsps..........sst..c.Y.pcsRchMTp.......-ssAslcGshp.u.G.u.......sEllVsDSHus.....hp.NL...hh-p...l.ct.....Rspl.l..pG..ps+.shuMhpGl....-.p.u.hDulhFlGYHAtA.G.s.c.GlLuHThsusshtplhlNGhthu.EsslNAthAuchGVPVsLloGD-s.h.tc-s...cthhP...psthVs..lKculu.p........huuhshsPppspptIptusppAl..ppttph................tshp.h.s.....s.PhplclphpssshA-.hhshhPslc..Rl-..u.pT..Vpapupshhcshphh.s..............................	0	54	107	134
+3757	PF02031	Peptidase_M7		Streptomyces extracellular neutral proteinase (M7) family	Mian N, Bateman A	anon	IPR000013	Domain	\N	25.00	25.00	26.20	25.30	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.66	0.71	-4.44	4	82	2012-10-03 04:41:15	2003-04-07 12:59:11	11	2	55	2	34	84	5	131.00	48	61.41	CHANGED	AVTVsYsASsAPSFpoQIApusQIWNSSVSNVRLptGSs.ADFoYhEGNDsRGSYASTDGHGRGYIFLDYpQNQQYDSTRVTAHETGHVLGLPDHYSGPCSELMSGGGPGPSCTNsYPNSsERSRVNQLWANG	...........sTlhYsuSpAssFcutIspustIWNuS..VsNV+Lt..p.u.os...Achs.h.h.t..s.s.cspu.ohAsssGt...GpG.hIaLs.h.p.t.s.Q.t.YssTR...lsAHEhGHlLGLPDpYsG.PCSpLMSGuusGsSCTNshPsAsE+uRVpphaA.G.............	0	11	25	33
+3758	PF01457	Peptidase_M8		Leishmanolysin	Bateman A	anon	Prodom_3085 (release 99.1)	Family	\N	19.30	19.30	19.30	19.30	19.20	19.10	hmmbuild  --amino -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.83	0.70	-6.16	8	1086	2012-10-03 04:41:15	2003-04-07 12:59:11	11	33	163	1	602	1111	26	328.90	21	71.05	CHANGED	H+CIHDtLQARVlQSVAtQ+hsPuuVSAlGLPYVosssh...tpAsssDauhusuoo..VsRAAsWGsLRIsVSsEDLTDPuYHCupVGQplsNHtGslssCTAEDILT-EKRDILVpaLlPQALQLHs-R.LKV+QVQGcWKVTGMssslCucFKVPssHlTs.....GVoNTDFVLYVASVPSE.....uVLAWAsTCQVFuD.G+PAVGVINIPAAsIsSR..YDQlsTRVVsHElAHALGFSs...sFFcss.GIlppVoslRGKsa.................................sVPVINSsTVVAKAREQYGCsoLEYLElEDQGGuGosGSHlKhRNApDELMAPsuu..AGYYoALTMAlFpDLGFYpAcFopAEsMPWG+ssGCsFLocKC....MEcNITpWPuM.FCN.......copsshR..CPTsRLsLGoCslssYpssLPsYaQYFT.........sssLGG.SsFhDYCPallsau..........sGuCsQcsSsAsshhctFNVFS-AuRClDG..sFpPKsssu..hls.YsuLCANVpCDTAs+TYSVQVhGuoGYssCTPGtR.lcLuTVSsAFpcGGYITCPPYVEVCQuN	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t......t........sDh..hhhh.......................................hu..A.h..C..............................................+.....PhhG..h...h.....p.....h.......s..............t........h............................t................................h......t.....h......hh......HEhhHsL.........G.Fs................hh...t.............................................t.......................h...........t..t.....................................................................................h.hl......o.s.p......sh.t..h..s...+pha.........s.........C.....s.........h.........p.........t........hp.lE..s.........t..G...u...t....u....o....h.h.o.....Hhct.+...................h..sEhM.s.....s................................s.......ts.........h...h.........ot...h...T...hAh.h...p.....Dh.....G...a.Y.p..s..s....h..s....h..s..p....h....................WGpt...uCt...h..h...t.t.C........................................................as......................................C.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	425	463	569
+3759	PF01752	Peptidase_M9		Collagenase	Bateman A	anon	SWISS-PROT	Family	This family of enzymes break down collagens.	22.10	22.10	24.70	27.80	19.40	17.40	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.98	0.70	-5.51	7	608	2012-10-03 04:41:15	2003-04-07 12:59:11	12	12	306	3	82	554	4	282.40	35	35.67	CHANGED	hpplhtth.hG....uppDplWLuss-hhpYYA..shpt.s..lsttpt-LAt+lhP.pa.CpssuhIcupphosupsApuCclhtsK-ttFHpshpsspsPVtDDtssplcVslFsssssYhpY.hah.......FspsTsNGG.YLEGNPuchsN.spFlAYchtphs.Dl.lhNLpHEYsHYLDuRFspYGoFscshtcuphlWW.EGhAEYhHYpQG...hpAAhphhspG.chsLSslhsTT...a......SpDosRIYRWGYLAVRaMhE.pHspDspohLshoR.G.pas.au.tsthhs.hYss-athW	........................................ppl.phs.ls....ssp.cs...hWLhss.ulaYsuph..uphc.s.shs..thhp.Ah+hhPhhtpp.hhsAh.phps...hsupstsu.sslshpc.cc.t+pthh.s+s......shD.Dsshsl+sushsoc-ch++L.haA......pFt.psssNst.h.cGNPsDlh...shshasu.-..c..a..p.h....N....c.....hhh..scphshYl-u.h...spahoacR.T.s.c.p............S...............h...............hsh.p.hhtEas..HYhQG....pht...ssu.lh.....up.....G....c....h....h....s-..hhshh.pt.......usc.osplh.ht.lh..sth...-.....t....p...p.ssphhhh.u+h.G......pa-hYshths.h.u..hYsppapha...................................	0	22	36	62
+3760	PF00768	Peptidase_S11		D-alanyl-D-alanine carboxypeptidase	Bateman A	anon	Pfam-B_864 (release 2.1)	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.57	0.70	-5.10	12	8726	2012-10-02 21:13:33	2003-04-07 12:59:11	15	33	3497	44	1522	7430	2600	235.10	31	61.21	CHANGED	sspssstP.........plsApuullhDhsoG+lLYppsscphhs.ASlTKlMTuhlVhcAhpttplc.sshVslupssathst....tsSphhLc.spploV+-LlpulhlsSuNcAslALA-hluGup......csFVchMNstAcpLGl+NT+F.sspGLsscs...............hSoApDhAlluptll+t.h.pphphspcpphsFp..........phshhNpNtLlhpps..lDGhKTGaTstAGasLVuoAscs.shRlIuVVhsAps	.........................................................h............pl.sA.p...u.h.l.l.h.Dh...s...oG.....c...l....L....h........pp.....N....s.c.p.thsPASlTKlMT.uhllhcul.....p.t.....t.......p......l..................s..h......s...s...h..V..s....l.o.p...p.u...h.t.t.s...................sS...ph.h.l.c....s...G.p.p.lolc-LlpuhllpSuNDAulALA....-....t....l....u.....G..o.p.....................................p..sF.l..ph.M.Np.p.A.c.p.LG.h..p....s.....T.+.F.h....s........s..s........G.L.....s....s..s..s.t....................................hooA.cDhAllu.pthl.....c.....p......h....s...p...........h....s....h.....t...p....p..p.p...h...s...a.s..............................shp.h.h.....N......p......N.....t.........L...l..........h............p......t.......s.............................s................l....D....G...h.....KTG...a.T.stAG..as..L.lu......o.......A......p.......c.......s.......s.......h......R..l..I.s.VVhsu..s..................................................................................................	1	486	949	1228
+3761	PF02113	Peptidase_S13		D-Ala-D-Ala carboxypeptidase 3 (S13) family	Mian N, Bateman A	anon	IPR000667	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.31	0.70	-5.98	9	2907	2012-10-02 21:13:33	2003-04-07 12:59:11	10	7	1969	75	742	2721	1248	317.50	25	88.36	CHANGED	LstslsshltD.PpL.Gu.sGlhlpcssoup.lapapusp.hlPASstKLlTAsAALhsLGssacFoTcVhssG....tshpGsLhlhGuGDPTLssps............lsslscp....L+cuGVpsl.phslhlDsSlFsu.shusuW..sD.s.sasuP.sushl......DsGph.splss..t.Gp....p.ss...h...t......ttusts.........hs.pphhlpGsls.t...h..shsVpssuthAuchhpcpLtttGlphsuslshssss...puupsLAstpSsPL.clLppMhKpSDNhhAEslh+tluhsh.ptPuoapsussuVpptL.sphGlDssshhLtDGSGLSRpshloucTlsplLpshs..ppsshpshlssLPlAGts.....GTLpsRht....spsssGhl+AKTGoLouV.uLuGa..........lpspsGchlsFuhl.N...hsstsspshcsshsthtspl	.....................................................................................................t.....huh.l.p.ht.....s..s....t....h..h...t.h..p..sp....h..PASs.Klh.Tsh..A.Ah.........L....s.s..s..ap..h....p....Tp.l...........h.................p.s.....................................tu..........sl...hh.h.hsuDP..h..htt...tp....................................h.....t..h.h.tt...................l.p......t.....t........G...l...p.....p.....l...............p.l..h...h...Dt..oh....a.........t...........t.....h..s.......s...........h...........t..s..............................s........tsh.h..............s.shh......................................................................................................................................................................................................................................................................................................................................p....t...h.hthh.t.ht.t....s....h.t....h...................s........t........h......h.......t...........t..s..................t...sp..........l...s...t....h..........p..S....s..l........p..llp.h.p.SsNhhA-tl..h....h..l.............u..................h.....................t..............................s...........s.......h........t......t..u.....t...s.........l......p.p.hl....t......p..h..G.l...s...h...s.......s.......h.......h..h..D.GS.....GL.....S....pt.......shlsst..hhph.Lthhh.....................pp.........................h..h...p...l.P.lu.Ghs...............................G.olp......R.ht.......t....h..tu.ltsKTG.o.............L......p.....s...........l..........................sluGh..........hh....s.t...s.G.p...h.hhs...h.st..............................h...............................................................................	0	232	506	664
+3762	PF02129	Peptidase_S15		X-Pro dipeptidyl-peptidase (S15 family)	Mian N, Bateman A	anon	IPR000383 & Pfam-B_2704 (Release 7.5)	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.90	0.70	-4.98	48	2545	2012-10-03 11:45:05	2003-04-07 12:59:11	13	23	1647	54	719	8025	2907	265.50	22	43.65	CHANGED	DG..scLtsclhpP......psstslPsllptoPYt..tpp.hssshthtpst.....................................................asscGYssVh.-sRGptsS-Ghhsst..........s.pEspDstssI-Wlss..............p.sWssG+VGhhGhSYtGhhshtsAs...............sss.uL+slsstsu.....hsshas..hhhpsGshttsshhsh........................sshttthhupthsstphhpthht................htthhp.hhtchcpp.......................psshssaWpspsh...p....ph...stlcssslhspGhtD.shh.psshphapsLpsss......................+LhlushsHst	...............................................................................................................................DG...shlts..slhp....P...........s.............ts.......tp.hP.....s..l..h..p..t..s....P..Yt........ps....h.h.p...p.h..s..h..h..t.h...........................................................................................................................................................as.s..c..G..Y..ss...lh...s..s.....s......R.....G......s......t........p........S....p......G..h.h.ssh.............................shp..E..h.....p..D..s..h...s.l..I...-......W.l.ss............................................p...s...W......s......s...G.....p.....V.G.h..h..G.hS.Y.h.G....h..h.p..h....t..s...A..s...............................p..s..s..s.....s...L....c..s.....l...l...s..h...su.........h.s..s...h......Y...p..........h...h...h...p...s......G...h......ht....s......s...h..h..h...h..................................................................t...h...h....t...h..h........s...p....t.........t......t..h...h.t..............................................................t...htt..ptt...............................................p......s...t..h....s...p....a..W......p...p...t.sh.....................h....................ppl...p..ssshhstG...h.tD.shh..t..tsh.ph..a..p.tlttt..............................phhh.t.htHh.............................................................................................................................................................................	0	221	468	626
+3763	PF00716	Peptidase_S21		Assemblin (Peptidase family S21)	Bateman A	anon	Pfam-B_729 (release 2.1)	Family	\N	20.60	20.60	21.20	21.20	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.07	0.70	-5.10	11	192	2012-10-01 19:43:34	2003-04-07 12:59:11	12	2	89	47	0	212	0	280.20	30	49.47	CHANGED	ELhLs.-sVpptLPsss........slPlNI-HpssssVGpVlulhssppGlFhlGllsssphhslLppsupsuhhuppss...shh..-thL.hLosaLPuLSLSS++....husspts...-sshFpHVALCulGRRhGTlAlYups.-hslstFscLSsup+-tlhp....sppssu.............hhtsshps.spsLLusAlcshal+-RhshLppc+phAGIt.scoYLpASssh..tsssp.pssspph........................shpsss...........shsssps...............spshssssPsu......................ssssusustsh......tDhlhlPtspatpLlsupttsts....ss.sssthhhPsssss.sshP	.........pLhLs.-hVpthLssts.........slPlNlsHptss.VGtVhulhss..cG.FhlGhlsssphhpllppsuptshhsptss........................-.ll.hloshhPulSLSSh+................tstt.s......................stshFtHVuLCslGRRhGTlssYsts.-hslt.F.tpLo.sp+ttlht................stt.hs................ts.tsshps.shsLLusulsshhl+-Rhshlt.c+p.sGlt.tpoYlpASt......t.t.........tt...............................s.............................................................s.s..shhssh........................s..ssssssushs.s......t-hlalPtsta.pLls..upttst.s.....s..sts..h.P.......................................................................................................................................	0	0	0	0
+3764	PF00717	Peptidase_S24		Peptidase S24-like	Bateman A, Finn RD	anon	Pfam-B_616 (release 2.1)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.42	0.72	-4.33	228	17337	2012-10-02 16:34:55	2003-04-07 12:59:11	18	67	5051	47	3901	12330	5963	72.80	24	32.79	CHANGED	pVpGcSM....t..sslh.sGDhllVc...pts........................psppG-..lVlh..phssp.............shlKRlh..thsssthh..................hsslhlssp	..........................................................l.GsSM...............p.s.s......l.........h......s..........G.........D.h..l.l...V.c...........+ts..................................................................psppGD..lV..lh.........phssp.....................................shlKRlh......th....s...s...c...h...h.h....................t.l.h......................................................................................................	0	1246	2442	3261
+3767	PF03572	Peptidase_S41	Peptidase_S41;	Peptidase family S41	Griffiths-Jones SR, Finn RD	anon	MEROPS	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-11.05	0.71	-4.84	142	9366	2012-10-02 13:07:06	2003-04-07 12:59:11	13	89	5410	38	2078	8432	3390	171.70	27	34.34	CHANGED	plGYl+lssF..t............tsspphpptlpcLpp......pshculllDLRsNs.......GGhlstulplsshals.......sssll.pp....sptsppp......................................................t.t.t....................hstPllVLlspsoASAoEIhA.uAlp-tpRu..hllGpp.TaGKGslQshhpL....ss............ssslp...lThu+ahsPsGps.lpth...GlpPDltl	..........................................................................................................plGYl+l.s.s.a..tt...........................................tsstt.lp.p..hh.pp.Lt...................sspul.l.lDL.RpNs.............G.G.h...l..s.t.s.s..t..l.s.s.hhhs........sssl..h....p..h......sph.hs.pt...........................................................................................................p.hs...sp.h.........................................................h.tsts.llVL.sstt.ou...Su....uEhlA..tsL..p......c......h.....p..RA......hl.l...G...cp...Th.....G.....t.....u..h.....s...p.p...h..h.pl.............ss................................s.h.h.lp.......ls.h.u.+..h...h..s...P...p.G..ts...hpth..........GlhPsl......................................................................................................................................................................	0	802	1448	1814
+3768	PF03574	Peptidase_S48		Peptidase family S48	Griffiths-Jones SR	anon	MEROPS	Family	\N	21.50	21.50	22.20	31.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.86	0.71	-4.20	4	138	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	109	4	5	124	0	146.60	84	79.25	CHANGED	YlEQGQNLRMTGHLHHIEPKRVKVIVEEVRQALTEGKLLKMLGSQEPRYLIQFPYVWLEpYPWpPGRsRIsGsSLTs-EKphIEsKLPusLPDApLINSFQFMELIEFLH+RSQEDLspE+RMsLSEALAEHIKRRLlYSGTVT+lDsP	.YLEQGQNLRMTGHLHHLEPKRVKlIVEEVRQALTEGKLLKMLGSQEPRYLIQhPYVWhEKYPWpPGRSRlPGTSLToEEK+QIEpKLP.....sNLPDApLloSFEFLELIEFLHKRSQEDLPscHQMPLSEALAEHIKRRLLYSGTVTRIDSP.	0	0	4	5
+3769	PF03575	Peptidase_S51		Peptidase family S51	Griffiths-Jones SR	anon	MEROPS	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.95	0.71	-4.48	24	2034	2012-10-03 00:28:14	2003-04-07 12:59:11	12	9	1732	6	487	2189	1077	152.20	25	62.84	CHANGED	Yhpphtpshpp.LG......ht.lssLchst........-hpstlppsDhlaVGGGNTFpLLptlpcpsLsphlpctl.ppG.hsYhGhSAGu......hl.....s.s.oIpsss...hs.h....p..sa...p.u......LsLlsatls.PHa...sstp.t.....E...shtpplppa...psh.slluls-GsAlhlpscp	.........................................................hhtsht..lG......hp....lph.lc.hhs...............c..ht.tl...p...pA..-....hlhluG.G.N.oh.p....Ll.....pph......c.....c.....p.....s.....lhp......hlp...c.hl....p......pG...slhh..Gh.SAGA.......................l..................h..ss...s.l.t.s.s.s......p.h.s.s...................p.tsh.........s...u.....................................L.sL..h.s.....h.....t......ls..PHa.....sst..p.............p...shppclpph............t.s...p.......h..s.h.luls-s.sslhlptt.p..............................................................................................	0	177	325	427
+3770	PF03576	Peptidase_S58	Peptidase_T4;	Peptidase family S58 	Griffiths-Jones SR	anon	MEROPS	Family	\N	22.20	22.20	22.70	23.00	21.10	22.10	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.01	0.70	-5.25	108	1255	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	969	47	448	1181	478	314.80	32	91.85	CHANGED	hNuITDVsGVpVGHsTl.ttt......................sl+TGVTsIlP+.ts..ppsssAusaVhNGsGc.spGhshlcEhGhlps..PIsLTNThulGh.sssullphhhst..s..........hshshPlVsEs.DuhLNDItuttlp..........tpcshpAlsu.A..................tsss.......hspGuVGAGTGMhshshKGGlGoASRllst...........uaTVGALVtuNa.Gph.....tphhl.uGh.lG.pchushs.s.........................................................................tpGSlIsllATDAPLsspQhpRLApRAtsGlARsG..ustssuSGDlslAFSTusps.tstst................l.pt...ls.LapAAupusEcAIhsulhsAps.hsG...t..pscth.ul	.........................................................................................h.ssITDVsGlpVGHtoh..p........................thtTGlTVlls.....................ppsssAulcVhsGsst.optsshlc.hshlpp...sllLosspuhGh.uusGlhchhhcp.....sh......t.hpssssssPlVst...u.hL.....Dlt.stssp..................................tphuhtA.hps.A.........................t.s.s..........hs..pGs.VGA.Gs.....Gh.......s.......s.........h.....s.......h................K.......G.......G.....l......G.o...A.....Sth.lss......................shsVGALVhsNh..Gsh....................tthhh...ssh.....su......t..h..tt.h......s..................................................................................................ttsstsosIsll.ATDAsLsptQhpRlAttApsGlARsh..ssas.hsGDhhhAhoTupths...t.............................................lsslhtAAA-shpcAllpulhtAps.h.u.........h............................................	0	134	269	374
+3771	PF00082	Peptidase_S8	subtilase; 	Subtilase family	Eddy SR, Sonnhammer ELL	anon	Overington	Domain	Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see Pfam:PF00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null --hand HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.35	0.70	-5.26	63	15113	2010-07-03 07:17:22	2003-04-07 12:59:11	17	580	3631	324	6420	14631	3376	299.50	19	44.44	CHANGED	slullD.oGlp.....ssHs-lp......................................sph........t...ua.........................................................................................shssss.......................p.ttstss............................HGT+sAGhluuss...tss.s..hGVAhsuplh...............ul+l...lssst..ssss......................hhpulphss.................pph.clhshSh.Gs............................t.....psshhptsh.........p......stsspGtlhVhAuGN......ssssss.....................sssPuhh........psh..loVGuss......................................................................................................................................pp.................s.....ph....s.aSsh.........s............sss........clsusGs..sh..........ssh...sssp..................tshtthsGTSh.........AuPtsuGhhAllhp....t.Pph...............ospplpt.hllpoAp.hs...........................hsphh......GaGl..lshtpslp	................................................................................................................................................................................................................................................................................lsllD.oG....l...............p.p......p.ht............................................................................................................th..................................t...h....................................................................................................................................................................................................................................................................................................................................................................................s.h....ttt....................................................s.t.ts............................................................................HGT..ps.A.u......h.......l.....uu..........t.................t................................................................t........................h..................G........l........A............p.....u...p.lh..........................................sh.+h............hssts.....sptts.....................................................lht.u.lphsh.................................................................pps.sp..l..l..s...h...Sh...Gs....................................................................................................................t..t...h.....h....p..t...sh........................p.................ts.h..p..p..G.....h..h.h..l..s..A......A..GN..........................s.u....s.s.st..........................................................................................................................................hs...P..uth................sss.......lsV..uu...s..s...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pp...............................................s..............th...............utaSsh.............................u................................................................s.h.............................-..l...s....A.....P....Gs...sl......................hush.........ssst.....................................................................................................................................................ht.hhsG.TS..h...................................A.s.P..hl..u.....G.hs.A.Ll.hp.................t..s.ph..........................................s.st.t....l.....pt....h....lh..p..s.....u..t...............................................................................................u.G............t............................................................................................................................................................................................................................	0	2244	4178	5504
+3772	PF00326	Peptidase_S9	Prolyl_oligopep;	Prolyl oligopeptidase family	Finn RD	anon	Prosite	Family	\N	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.29	0.70	-5.12	70	9052	2012-10-03 11:45:05	2003-04-07 12:59:11	16	114	3171	311	3615	20889	7745	202.90	21	30.52	CHANGED	ssF......s..tphthh..............spGhlhshsshRGuuthGcpatcss.ptphtpsshsDhlsuscaL......hppt..assss+lulhGuSsGGhhsusshs.tpschF+sulutsshsDhlphhtts......hst.pa.caGss.p..stchYpthsshsshcshh..........thsshLlhpGhpDsRV.h.tcuh+hhstLp.........ppGss.hhhth.ssuGH...ustpsptph.cthtphhuFhhpthshp	..................................................................................................................................................................h..h......pp.G.hh.hhh..s....s.....h.....R....G.............u....s...........t.............h.......G...........p...t................a........h................p.......s...........h.......h.......t.........p.......h......t.......t........t......s.....h......p......D....h...h....s.....s...s...c..h..l.............................hp..p....s.....h....s...c...s....s.....+...l..ul.h...........G..t.S.h...G....G.....h...h.....s.........s............h..............s.............h.............s......t..............t..............s...........c..............h.................F................p...............u............s..........l............u......t..............s.........s...........l...........s.....D........h.....h.........t.........h....h....t.....t.................................hs.t.........p.....h.........p.........h.......s............s.........s......p..................s...p...h...a....p....t....h.......s........s..h...s.......h.c.p......................................hts.s..l......L...l...h..p..G..t...p..D....s...p.....V.......h....t.p...u....h...p..hh.s...t.Lp........................ptst..s...h..t.h.........h.........h.h.........s..t....s..H.............u.h....t....p...s....p...t...p....h.......p....h.......h.t.thh..t..ah.phh...h................................................................................................................................................................	0	1280	2250	3034
+3773	PF03418	Peptidase_A25	Peptidase_U3; Peptidase_M63; 	Germination protease	Bateman A	anon	MEROPS	Family	\N	19.70	19.70	19.80	19.70	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.11	0.70	-5.72	2	602	2012-10-01 20:58:29	2003-04-07 12:59:11	9	2	413	2	149	477	6	219.30	31	94.65	CHANGED	AVEsK-hhhppQshPsp..EIKGhI.KE+-ctGlKIphV-lTcEGAEh.GKKcGRYlTLEu.GIREpDoEhQEthptVFAcEhshFlcsLNIscDASCLlVGLGNhsVTPDALGPhAV-NLLlTRHLFcLQPEsVQ-GaRPVSAhsPGVMGhTGIETSDIIhGVlcpspPDFlIAIDALAARulERVNsTIQISDoGIHPGSGVGNKRK-lSh-TLGlPVIAIGlPTVVDAVoIsSDTlDaILKHFGREMK-p.+PS+SLlPuGMTFGcKKhLTEDDLPspcQRQoaLGhlGTL.--EKRpLIHEVLuPLGHNLMVTPKEVD.FI-DMANVlAsGLNsALHccVsQENhGuYsH	...................................................................................Gh....p..p.....t.....t..t..hhl.s...lp.l.......p...s.t.p.....h.sK...GpYlTl-h..t....h.t..s.th.pph.t.hsp.ht.h..............................p.......ph...LllGLGNhplTsDuLGPhshpplhlTRHl.h.p......s..p.....h.....t..t.h.p...l.sultPGVhu.TGhEos-ll.ullpphpPchllslDALAuRphpRlspoIQlssoGIpPGuGlGNpR.tlspcslGlsVlulGlPTVlpAsslsp-shp..h..................................................................................................................................................................	2	82	127	135
+3774	PF01136	Peptidase_U32		Peptidase family U32	Finn RD, Bateman A	anon	Prosite	Family	\N	21.30	21.30	21.30	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.49	0.70	-5.43	166	7851	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	3207	0	1379	4878	390	231.70	27	57.79	CHANGED	lppltchlp..h.h.......................phtsDu...lIlsDhGllphhcct.splslHsSsphsltNhpslphhpch...GhpRlVLuREL...olcclpp...ltp..ps...........s...lElElFlHGul...........CluaSG+ChhSph.htsps...................sN.+GpCs.psCRh.sat....................................hhppt.pstp..................................ahhSspD.l..shlpplscLhcsG.lsulKIEGRh+s..tYls.plspsYRpslDsh.tt.............t.t..phhppLpph..hpR.......shssGahhspsst	........................................................h...h.chlc..l.h.......................p.hGsDA....lIhu...D.Gl......lt.....h....s.......p....c.......p......h......P......p...l........t......l..HhS..sQssss..Nhtslc.aa.pch...G..........h.p...RlVLuREL.....ohcpltp...............lpp....ps.......................s.h..-lElFla....Guh............Clu..aS..GRChlSsa..hst.+s...................sN...pGs..C..s..psCRh...pap....................................................................lh-pt...pst..c.t.....hsh....t.....p..Gp.........................................................ahhsspD....l....shlpplscL.hc.t.G..lcSlKIE..GR.h+s..tYls.plspsYRpAlDthhts..........................p..thhpp.ltph........hpR.......shssuah.tp...p...............................................................................................................	0	454	880	1149
+3775	PF03577	Peptidase_C69	Peptidase_U34; 	Peptidase family C69	Griffiths-Jones SR	anon	MEROPS	Family	\N	20.70	20.70	21.10	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.26	0.70	-5.60	13	1802	2012-10-03 21:14:07	2003-04-07 12:59:11	10	11	864	0	402	1558	66	354.50	29	76.08	CHANGED	ACTTlLVGKpAShDGSThIARsED....tsushsPK+alVlps...ccQP+c.Y+Slhoshph...cLP-sPhpYTSsPsu....sspc.GIWuEAGlNpsNVAMSATETITsNpRlLGsDPhV..................psGIGEEDhlTllLPYlpSAREGVcRLGpllEcYGTY.EuNGlAFSDpcEIWaLETlG......GHHWlAtRlPDDsYsssPNQhsIDcFDhsDs....-sYhsSsDLc-FlcppHLs.shp......................tcFNhRcAFG.opscKDppYNsPRsWhhQ+aLs........P-hc..psPcspclPahp+...PpRKlolEDlKalLSsHYpsT.....saDPYGs..pGstpsccta.........R......PIGlNRoppsalLQlRsslPptluGVpWLuaGsssFsshVPFYssVscTPstap..cTsschoss..shYWts+hlAsLuDscYptassslcsa.cp	..........................................................................................................................uCTsllVGKpAohDGSshluRs-D.................t.h.sp.phhhh.s......t.p..t..t.t......h......h....s...................s....t..h.....ph..........l.P.....t.....p...s...h.....p....Y.ss....h.ssh...........................t.p...Gh..h....s..p....s..G..hNp....t....s..V..u....h....o....u....T.co..h.h.s.Npp.s.h.u.h..D....P.h.l.......................psGl.sE.ps......hhslsLPhhcoAREGVphlGpLl-c..Y...G..................s...........h.....E..............u.............N........u.............l.......h............huD.p.s.E.lW.a.h.Ehhu..............GH......p......WsAtR...l.PD...DsY.ssh.sNphtI...p.p.h........D...h...s....c.....................pshhhSsslhpasccpth...s..sh.p.......................................................t.F.shppsau.....s....t....s.......t...c.....th..Y...s...psRsWhh.......phhs...................Pphp..............p.s..p......s..t....phPhhhp.....s.p.+.plol.pDlt..hh.psH.apsT.........a..D.s.hs.................t......pt.a.....................................R................sIuh...pstpstlhQl..R..s...t...h...P.tt..hs.sl.WhuhG..sshsshlPaa....ss....h..p..p....h..s..ap...................t.s..s.t......p...h...s.p...............shaWh.phlsshs..pat.hh...pth...t..........................................................................................................................................	0	123	214	291
+3776	PF03419	Peptidase_U4		Sporulation factor SpoIIGA 	Bateman A	anon	MEROPS	Family	\N	25.00	25.00	27.20	26.60	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.54	0.70	-5.34	34	409	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	402	0	90	356	5	271.70	27	96.09	CHANGED	M...hlYlDllaL.NhlhshhLLhlTAthl+ppsphhRllhGuhlGuhhsllhhh.P......hhshhhphhhKllhShlhlhhuFuhcphth............hl+slhhFYhsoFlhuGuhhuhphhhptshhhpsthh.h........hsahhllluhsshahhh+thhchlpp+phptphlhcVplthsspphpl+uLlDTGNpLpDPlTptPVhlV-hstlcpl.hs.ph..........slpphtph....t....p+hRlIPY+ulGp.ppGhLhuhKPDplhI.pppchlpspcsllulspppLSspscYpullpPcll	............................lYhDlhhl.NhhhshhlLhhouhhh+t.phphhRllluAhlGuh.hslhhhh..P....................h.hs.h.h.h..p....hh...K.l..lhSllh.lhhuFshpsh+p....................ahpslhsFYhsoFhlGGshhuhphh..hps.st.h.h..shhh.............hs.hh..h.llhuhs..lh.a.hhh.c.thhc.l.c.p.p.p.hpts.lhclclpls.p..c.....p....lplpuLlDoGNpLhDPlTppPVhlhchss.lcph.hst.h...h........t.........ph...p.h..p............hhp+l..RlIPa+uVGt.ppthLhul+PDplpl.pps.p.p.hhhpcsllulssp.pLSspscYpsllpPphl.........................................	0	47	75	80
+3777	PF03411	Peptidase_M74	Peptidase_U6; 	Penicillin-insensitive murein endopeptidase	Bateman A	anon	Bateman A	Family	\N	20.30	20.30	20.40	20.80	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.57	0.70	-5.14	3	916	2012-10-02 01:02:30	2003-04-07 12:59:11	8	8	890	8	146	530	97	237.60	59	82.86	CHANGED	QSIGSYoNGCIlGAsALPscGEsYQVMRhsRNRYaGHPcMItaLERLSpcAussGhPTlLVGDIuMPuGGRFLTGHASHQsGLDADIWLp.MPKpRaTsApppcspALslVcRDup+VDs+lWsPs+soLIKLAAQDP-VTRIFVNPAIKpQLCpTAGsDRuWL+KVRPWaGHpuHFHVRLTCPADSsECEsQPhVPuGDGCGcELtSWF..EPPKPG..ToKPcKKssP....PLPhuCQAlLNuPsh	..........................QSIGSauNGCIlGAssLPl............pu-s...Y...QVMR..o..cpcR..YaGHPDLlh.F.I.QR.L..Sp......p.s.p..p.h..G.h.G.T.l.L.IGDMuMPuGGRF..suGHASHQoGLDVD.I.aLp......LP.K..p....R.a.o....s......A....Q..L...h.....c.P...p.A..lc.L......V.s......+......D......G....+....+V..l.s.shWpsphh.u......LIKLAApDp..-VT..RIFVNPAIKpQL...C.h...-.....A.......G.s.D.....R..........s.....WL....RK.........V........R.P..W..F....t.................H+uHMHVRL+CP.As.Sh.ECE-QshP.....Ps.....GDGC.G.A.E...L...pSWF...............-P....P.K..Pu......os.K..P....c.K.K.s.P..P................PLPPuCQALLcp.s.h............................................	1	31	69	105
+3778	PF01343	Peptidase_S49	Peptidase_U7; 	Peptidase family S49	Bateman A	anon	Pfam-B_707 (release 2.1)	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.46	0.71	-4.44	20	6794	2012-10-02 13:07:06	2003-04-07 12:59:11	13	22	2890	24	1513	5321	2903	149.70	26	46.31	CHANGED	pthcptKPVlshssshuASGuYalAosA-+IlusssullGSIGVhhphsshpshlcKlGlshpslpsGpaKsss..ohhcshos-t+phhQphl-psaphFlppVAcsRslsssplcplApG..clapGppAhcsGLVDElGsh--Alsphtp.hspls	...............................................t..tptsKPlh.ssh....s....s...hu....A....S....G....u....Y..hlA.s.s.A....s...c...I.h.s..s..P..s..u..l..l.G..S....I..GVh.s.t......h.....s....h.p.p............h.L.c.+.h.........G............l.chc.........hhp...s...G..p..aKssh...........shhpshos.c...s.+..p.thp.p.h.l..sp.ha.ptFlp.hV....u....p...sR..............t......h....s.........h........p.......p.......l........p........p........l...A...pG.........cha.......p......G.......p......p.......A......h......p...h......GLlD......pl...u.s.h.cc.s.l.tthtp..........................................................	1	508	959	1257
+3779	PF03420	Peptidase_U9		Prohead core protein protease	Bateman A	anon	MEROPS	Family	\N	22.00	22.00	22.10	39.20	20.00	21.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.40	0.70	-5.07	2	91	2012-10-01 19:43:34	2003-04-07 12:59:11	8	1	86	0	6	81	1485	196.80	38	87.65	CHANGED	.E.QLLIEsWG.su.hhsts...PhlEu+.st-hGhc..LYIEGIFMQupVVNRNtRhYPK+lhEpAVpcYIpEQVhTpQALGELNHPsRuNVDPhpAAIhIp-hWWcGssVhG+AhVlpss+..Gphltu.IcuGWlPGVSSRGLGSlpps.-Ghp.Vp-.F+LTVGVDsVWGPSAPsAaVpP..lTES.......pTtEhspSsDstahtLAEshKphL	................................t...............................pppG.tK..ha.IEGIFhQu-lhNRNtRhYP.+plLp+sVsc.Y.pc..lp..sppALGELsHP...s.......ts.....s.........ls..psuhhIpcLhh..c..Gss...shG+A+l.l.-ssp..GchltuLlcu.Ghh.GVSSRGhGolp.cp..cGhslVp-sFhLssusDlVhsPSAPDAaVps..IhEu..p......................................................h.....................................................	0	3	5	6
+3780	PF03036	Perilipin	perilipin; 	Perilipin family	Griffiths-Jones SR	anon	Pfam-B_1154 (release 6.4)	Family	The perilipin family includes lipid droplet-associated protein  (perilipin) and adipose differentiation-related protein  (adipophilin).	28.20	28.20	28.60	28.50	27.70	28.10	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.30	0.70	-5.63	17	474	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	106	1	237	475	0	278.60	26	73.43	CHANGED	husstps...QpsVVsRVssLPLVSSThshVpssYsuTK-sHPhl+SVC-hAE+GVpolsosAhsuApPllp+LEPQIusuNchAC+GLD+lEcpLPlLppPs-plhups+th...........l.tsVsuAK-oVsp.loussshshuuspsus-hT+shhstsh..VhuoRhsphsosuVDssLspSEclVDpaLP.o.-cELts.upp........................scu.-sssh....t.psuYaVRLGuLSs+lRcRshppols+l+pu+ppsQEtltQLppshsLlc.sppshp...pphhtt.tphh.hWhphppst.pst..............tp.pplEtcslslsRslT.............ppLQosshslsuSlpGLPsslp-pstplpptsttl.tshtshtshpc...ls.thLspu+tpltphptsLDplh-hllsNs	...................................................................................h..........p.pslpRlhplPlVpushphhppsY..ps...Kpp.s.h.lt.shphsEps...........l.......sh..A...h....t.s.Pl...l.p....p....lp.s....l...sh.ssphss+GLD+lEpplP..h..l..p..P....sp....p.........l......htp...h+th..................h..t.l...ps.......stssls..............hst...t..........th..........th............hh..t..s...h..h..phh.......t..sh-.s.....h.s...hs-.h..l..-.hl.P.s...pt-.t..st.p.....................................................................ps.p................phh.+lupLutphpp+shppshtplpth.p...t...pphh..l..sht.L.ht......................................................t................................p......h.tt............................tpl.thh..h....ht.hP...th....t.h.th..................h..........h......h..h.t.h.................................................................................................................................................................................	0	54	73	152
+3781	PF01497	Peripla_BP_2		Periplasmic binding protein	Bashton M, Bateman A	anon	Pfam-B_461 (release 4.0)	Domain	This family includes bacterial periplasmic binding proteins.  Several of which are involved in iron transport.	27.50	27.50	27.50	27.50	27.30	27.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.16	0.70	-11.13	0.70	-5.24	33	15783	2012-10-03 15:23:08	2003-04-07 12:59:11	13	38	3934	62	3407	11094	1155	233.80	16	72.71	CHANGED	lsshshssspllhtL...Ghtsplsussstspt.htttt...............sh.........spssstpphsh...................EplhslcPDlllssphh..........sph.chhptthsslshsssp.....................pshhctlptluphhspp..ccAcphhpphppplspsppphssh....ptpshhlhhhttt....thhhhhussshhsplhct.huhpsh.hstt.......tpttt.luhEplhs..hssDhllhtsp.....................pppshctlhps....sthppl.sAl+ss+lhthssph	................................................................................................................................hsht.t.h.chhhtl...............s.h..t...s.........h....s....u.......h....s....t............s...p.........................................................ph.............................................p..l....u...s...h....t...p...s..sh.........................................................Et.l......h..s.......l......c........P..D.....L.l...l...s.sstt.......................tt.th.....p..h.....h..p.....t....h....h......P...s...l....h...h...s..h.s.p..................................psht.p.p...l.p....p....l.u....p.hh...spp............c.c..A..c...p.....h....l....p....p....h...c......p..p...l...s...p..h....p...p.phtst...............ttp.s.h.h...h..h...h..h.tss.............................t..h.h..s...h....s...s..p.....s.....h...h...s...p..l..l..pt....hG.....h...p.....s..s...hss...............................ttsh.h..p...l..o..h...E..p...l...hp........hs....P..D.h..l..h.lhst............................t.t..t.t...h...p...t....l....h...p.s...................s.h...h...p.ph..sAl.+ssclh.h....t.....................................................................................	0	1003	2187	2887
+3782	PF00532	Peripla_BP_1	periplasmic_binding_like; 	Periplasmic binding proteins and sugar binding domain of LacI family	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Domain	This family includes the periplasmic binding proteins, and the LacI  family transcriptional regulators. The periplasmic binding  proteins are the primary receptors for chemotaxis and transport of many sugar based solutes.  The LacI family of proteins consist of  transcriptional regulators related to the lac repressor. In this case, generally the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain (Pfam:PF00356).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.68	0.70	-5.20	6	5137	2012-10-02 13:57:41	2003-04-07 12:59:11	16	10	2047	27	638	25439	2217	255.60	21	79.54	CHANGED	shslGhllsps..csPa....ahclstulscAuppaGhslhLlssspps-tt...pthc.LtsptsDGllIs.ohssc..scIpthtct.shPVItsscshs.s......sVPssh.D.shpAut.psspaLlptGHcp...l...slhstssSsh.sstcRspGahsAltssGh....h+phplhpssschpsutpAlpphhpps..Pshp..AllshNDpsAhGuhhsh.tpGh.lcs.psVs..h.ulhuasuL........spsshl..s.lss.psstp.lGhpsu-hlhp.l........tp-pscslhIs.....thhhtcs	................................................................................................................................................s..tlGll.l.P....sl........pss.....a.............a.s...p.....l...h.p.u....l...p....p.....s........s....p.....p.....t.......G..........a.....p.....l.........h.......l.........h........p..............s............s.....t.....p......t....c.tt.............pt.l....c....p....l.......h.......s.......p.......t...l...D....G...l....l......l.......s......s........t.......s...............p................s...........p..........l......h.....p........h.......h.....p........t........s......h..P....l.......l...h...h..s....c..t.......t..s.s......................................s..l..s.....h....l.....h..........D......s.........h....p.........u.........u......h......p....h....s.....p........t.......L.......l.......p.........p......G.....p....c..+.............l......................u.h...l.....s.....u.......s........t........s...........t............h......s............s..........t.............c.........R......h......t............G............a.........p.......p.......A.......l.......p......p.....t.......uh..................h....p....................h..........h...........h........t.........s........s..............p............s..............h...............p.........t.............u..........h.......p........h.......h.......p....p..........h......h......p.............pt..................P...p.........hp..........ulh..s..h...s..-...p.h..A.h.G...s...h......h.....t.t...G..........h..p......h..s..........t..t.......l..............................s..h......u...h....p.....s.....h.........................t.....h.............s........l.....s............p..........................G...........s.s...p...hhh.t...l..........................................................t........................................................................................................................................................................	1	130	282	466
+3783	PF00141	peroxidase		Peroxidase	Bateman A, Sonnhammer ELL, Studholme DJ	anon	Prosite; PfamB-105, Release 14.0;	Family	\N	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.92	0.70	-4.87	162	7995	2009-01-15 18:05:59	2003-04-07 12:59:11	18	39	2016	398	2881	7388	3647	260.20	25	77.65	CHANGED	Vcphlpphhpp........psshus...sl.........lRLhFHD.........................................Chs...............t.GCDuSl.ll.......htsEcs.sss.Nt...uLc..uhc..................ll.....-slKspl-p..tC.st..h...VSCADll.................sLAucsulth...................s............GGP..hh.sl.hGRcDupsupt.tts...tl...........................................................P.................ss.t.shsp.lhptF.sphG.L.ssp-hVsL.u......................................GuHT..lGts+.Ct.h...........+h..................ths.thh...t.......C.......s....................h.h.D....os.................spFDNsYapsLhs....................................ptshhpoDtsLh....sss......pspshVppaAss	.................................................................................................................h....htthht...............tphus....hh..........lRhh.aHD................................................shs.........................................uGss..uuh.hh..............hss.pps.hss.Nt....sLc...uhc..................ll.....psl...K.pphsp.......t.................lShADl.l.........................sLAussulpt..........................................................s................Ghs...sh..shs.sG.RtDuhpspt..sth...t.l...................................................................P...................ss..hssspp...l...h.s.p...F...tp.hu.....h.s.s..p.Eh.V.AL..u................................................................Gu.H.o....lGt.sa.ss...........p............................t..th......t......................tspt..............hs.h..c.......sP...................................................................stasNs.aFtsLhs..........................................................................................................................ph..shh..poDhsLh..p..ss......th.c..tlschasp................................................................................................................................................	0	552	1714	2399
+3784	PF01328	Peroxidase_2		Peroxidase, family 2	Finn RD, Bateman A	anon	Sarah Teichmann	Family	The peroxidases in this family do not have similarity to other peroxidases.	21.00	21.00	21.10	23.70	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.05	0.70	-5.76	2	357	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	84	13	308	383	0	183.60	23	63.07	CHANGED	MFupll.hsuslssh.....tcs........psshhsassPGPsDsRuPCPAhNuLANHGalPHDG+uIoh.sl.sAh.sthsluss.hthAlssAhlls...stushhso.hNLs.LsE.ph.hEHDtShSRtDYhpussp.....DshsFstphFpp.Lshhsu.p.hshsshsth+htR.phppEhD..h.aotp+.l.sh.EouhhhuhluD...Psps....scl-Wh+haFppEphPY+.GW+.sSstppl..lsuh.utllhAs.....ssLPpG.ltssApsVsluFuu.hsPhhhshN........plhs	................................................sth................................................................a..ss..t..s......s...D........RuPCPuL.NsLANHG.........al.P..+s..Gt.s.l...o...ht...pl...h..p.....u........h..tp..s......hs.h....u..........s........................h......s....h...h.h...........h...h...............h.....h......................................................................................................t............h.........h.......s....L.......s....t........L..........s.t.......H.......sh..hEtDsSlsRtDhh........................................hht..............ht.............t....................s..............h...s.....h......p........t....................................................................................................................................................................................................................hhhhh.....................................................................................................................................................................	1	104	191	267
+3785	PF04088	Peroxin-13_N		Peroxin 13, N-terminal region	Wood V, Finn RD	anon	Pfam-B_8055 (release 7.3);	Family	Both termini of the Peroxin-13 are oriented to  the cytosol. Peroxin-13 is required for peroxisomal  association of peroxin-14 [1].	20.90	20.90	21.10	22.70	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.01	0.71	-4.27	29	243	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	221	0	175	247	0	154.00	37	39.23	CHANGED	GYG.........Gh.G..ts.s..shht..hspSTpATFQlIESllGAhGGFAQMLESTYMATHsSFFsMloVAEQFupLKssLGShLGIFAlh+al+plhtKlssthh...............tspuhssspF.ppFpspt....ps.ptt..........ts+.ShKPllhFluAlhGhPYLlsKllp	.........................hhsshYs.......uhh..s...s..s.ss.ss..phs.pp.hppSopusFQhIESIVsAFuuhApMLESTahAsaSSFh.........AhluVA-pFupL+spLuslhuhFsllRhl+plht+lpthhh..............hpssu.hs..stF..spapss.....t....s..t...........sss+sSphPlhhFlss.lhGhPYLhhKll.t......................................	0	50	87	141
+3786	PF04882	Peroxin-3		Peroxin-3	Mifsud W	anon	Pfam-B_6513 (release 7.6)	Family	Peroxin-3 is a peroxisomal protein. It is thought to be involve in membrane vesicle assembly prior to the translocation of matrix proteins [1].	26.70	26.70	28.40	27.20	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.32	0.70	-5.77	32	408	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	258	4	274	399	2	283.60	23	86.51	CHANGED	hsuhtsahpR+++KlhlsuullGusYl...lspashpK.lp-hpp+hsp-hhs+E..................pl+p+FcQsQp-CshTlLuL.LPslspslhc.tLssEplsppLppp+.........................................................................................p.............t....................................................................scsKhpLWs-LKIpolTRhlTllYolohLhlhhRlQLNlLGR+pYL-...........o...........................................................shthutsppttppsths................................................hpspppYLSh..SWWLLs+.GahplhshlcpsVpcsFssls.+ppLolschppllhplpptlpt........s........sspp..........hlshLlP...t....hl.po...................s.hss.s.....pssspLpcLlsETpcll..-SsshspVlpthlspuFsplh-plt.tphs.pt.s.s...........................tthsshsphp..............hpLAplLshlscQsptlssss.......................................sNpalpslpp.lccLcsFuAsVYos.F	........................................................................................................h.pppt.hhh.........shhssh...hh......h...h.h.t+......h.....p......p.....p.........tphh.pt..................ph..p.+..Ftp.pp.s.................s..h.h..h.h..ht..l.t.....hs.p.lh..lp............................................................................................................................................................................................................................................................................................................................................................................tp+hplWpplcl.shs+.hs.hashshL.lhh+lQlslluth.Yh.p..................................................................................................................................................................................................................t............................................................................pptaL.s.....ahhtp..Gh.th.p.hpt.l...t...ht.....hp.............p..p.....hsh.phtphh.tl...h..............................................h..hhhs......................................................................................h.thhtEh.thl..ps..h..lht...p..h.hhhpth..........................................................................................................h.hs.hh..ht........hhtt.........................................s.hl..t......h......ht.h...lht....................................................................................................................	0	85	138	210
+3787	PF03212	Pertactin		Pertactin	Mifsud W	anon	Pfam-B_2005 (release 6.5)	Family	\N	21.30	21.30	21.40	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.50	0.71	-4.39	8	2661	2012-10-02 14:50:22	2003-04-07 12:59:11	9	35	708	7	134	1809	3	114.80	27	13.74	CHANGED	VssLpLss.GsVsF.......usPAsssGpFpTL.slpoLSGoGsFhMNssls......supuDhLsVsssAoGpa+lhV+NoGsEPsSuss.LsLVcTs.GGsAuFTLuNtGGtVDlGTacYsLsss.....tNssWsLps	........................................................tl.hst.upl.h.......................p....s...t................a...sL..ss..s..p..L.s.G...s..G..s.hh.h..po..s..ls......ss..t..s..DpLsV...p.G...s...s.oG.s.hplt.V.ss...s...G...s.p.......s.s.......s.......s...s....t......lpllp.....ss.....s.....u.....s.....u........s......Fs......h......s......s.......................t....h....V...s......hGsYpYpLhps............s...tsW.Lh.s..................................	0	32	55	98
+3788	PF02917	Pertussis_S1		Pertussis toxin, subunit 1	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.90	20.90	21.30	21.30	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.55	0.70	-4.79	2	121	2012-10-01 23:25:29	2003-04-07 12:59:11	9	5	104	6	16	77	1	179.80	46	59.63	CHANGED	sPsthVYRhD.RsPE-lFppGFoshGsscNhh-Hlh....GRSh.luoSposhsuhp..tpah.Ehh.EH.hpthl.t.RAsp...HFhshhhpscs..shhtttpshF-.sDp.hsphGhhhhts.hsYQpEahsct.IsstNlR..othhhsulssEsspscassuR.VsppTRhN.Pp.ass+hp.hph.us...hhPs.Ghshshphp.spAhushs.ptGpuhsLs.ats.saS	...s..sDFVYRVDSpP.P.-lIFR...D.G....FohhG..h..NR...N..hQQaIS...........GR..SC...u...uGS..S...D.SpaIATT.So.....h......s.o.Ysh....t+uh.a.uR.ush.pG..plYRYQIRADNNFYShhsSl..s..YL-o.pGu..phs..th..p+sh...hph..Q...pEYlushsIhPENIpcAssl.laDu..sTG..s.p.s.s.p.h..NupYlshsTpSN..P...........................................................slh.hl...pthppphhshhh..hsth..ht.......................................................................	1	3	10	13
+3789	PF02918	Pertussis_S2S3		Pertussis toxin, subunit 2 and 3, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.90	21.90	23.50	27.60	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.42	0.72	-4.32	3	72	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	64	12	5	26	0	109.00	71	70.55	CHANGED	ThR+TGQPATD.HYYSNVTATRLLuSTNSRLCAVFVRDGQPVIGACsSPY-GR.YR-MYusLRRhLYhIYhuGLuVRVHVSKEEQYYDYEDATFpTYALTGISlCNPGuSl	.....TGDKT.....NAYYSD.EVISELHVGQIDTSPYFC.......IKTVKANGSGTP..VV.ACAVSKQSI.WAPSFKELLDQARYFYSTGQSVRIHVQKNIWTYPLFVNTFSANALVGLSSCSATQC.F......................................	0	3	3	4
+3790	PF02529	PetG		Cytochrome B6-F complex subunit 5	Bsahton M, Bateman A	anon	Pfam-B_1348 (release 5.4)	Family	This family consists of cytochrome B6-F complex subunit 5 (PetG). The cytochrome bf complex found in green plants, eukaryotic algae and cyanobacteria, connects photosystem I to photosystem II in the electron  transport chain, functioning as a plastoquinol:plastocyanin/cytochrome c6 oxidoreductase [1].  PetG or subunit 5 is associated with the bf complex and the absence of PetG affects either the assembly or stability of the  cytochrome bf complex in  Chlamydomonas reinhardtii [1].	20.80	20.80	20.80	20.80	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.63	0.72	-4.43	17	647	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	629	9	42	207	66	35.10	81	95.05	CHANGED	MlEPLLsGIVLGLlPlTlsGLFVsAYhQY+RGs.phsh	.....MIEshL.GIVLGLIPITLAGLFVTAYLQYRRGDQLDl.....	0	13	32	40
+3791	PF05115	PetL		Cytochrome B6-F complex subunit VI (PetL)	Moxon SJ	anon	Pfam-B_6510 (release 7.7)	Family	This family consists of several Cytochrome B6-F complex subunit VI (PetL) proteins found in several plant species. PetL is one of the small subunits which make up The cytochrome b(6)f complex. PetL is strictly required neither for the accumulation nor for the function of cytochrome b6f; in its absence, however, the complex becomes unstable in vivo in aging cells and labile in vitro.  It has been suggested that the N-terminus of the protein is likely to lie in the thylakoid lumen [1].	21.70	21.70	22.80	22.70	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.14	0.72	-4.04	28	723	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	681	2	17	306	0	30.30	69	83.62	CHANGED	MhTllSYhGhLhuuLshTlsLFlGLsK.IcLI	........M.TITSYFGFLLAALTITssL.FIGLsK.I+LI.......	0	8	12	14
+3792	PF03742	PetN		PetN 	Finn RD	anon	Pfam-B_3260 (release 7.0)	Family	PetN is a small hydrophobic protein, crucial for cytochrome b6-f complex assembly and/or stability. 	20.30	20.30	20.50	20.50	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.25	0.72	-4.38	22	1420	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	1364	8	44	221	4	25.50	91	97.19	CHANGED	MDIloluWuuLhshFTFSlALVVWGRNGh	.............MDIVuluWAALMVVFTFSLSLVVWGRSGL.	0	13	31	40
+3793	PF04614	Pex19		Pex19 protein family	Wood V, Bateman A	anon	Wood V	Family	\N	22.20	22.20	22.30	24.10	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.82	0.70	-4.76	27	341	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	273	5	218	335	3	236.60	24	75.49	CHANGED	ts-...........................sppshhpphppphppLhs.................................tttssptppphpphhpphst................ppsssstpsppss..............sFpsslpcThp+Lpcuucplssshtt.............s--hLsplLpshshss..........sss-tshtthl.sMMpQLsSKEVLYpPlKELpsKaPtWLcppps..plspE.chp+YccQhplsscIlppFEp..............tsYsDpp...cpct-tlhcLhpphQ-hGpPP..............sELluphsss........................tstsh.sshstt..-sCppp	.......................................................................ttt.t...........p.pt.h.tpLht..............................................t..thttphtphh.pthtt..................................................................t.th.tt....p.p..t.........t..t.......t............................pFppslpcThpt....lp.c.s..up...p.......hpssh.....................--...l....s.p..hhcths.s.t............................tssct....sh.shht....sh.MppLhSK-l..LYp.PhK....El......s-K.......aPpWLpppcs...........plstE.-hcRYpcQhplhpcIsptaEp........................ps.sDpp........tchchlh-...lMpp......hQphGpPP...............p-L.su-hsss..h............................s.......tC..................................................	0	68	120	177
+3794	PF04757	Pex2_Pex12		Pex2 / Pex12 amino terminal region	Bateman A, Wood V	anon	Bateman A	Family	This region is found at the N terminal of a number of known and predicted peroxins including Pex2, Pex10 and Pex12. This conserved region is usually associated with a C terminal ring finger (Pfam:PF00097) domain.	22.20	22.20	22.90	22.40	21.70	22.10	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.47	0.70	-4.94	113	868	2009-01-15 18:05:59	2003-04-07 12:59:11	9	26	288	0	602	841	8	218.00	17	58.58	CHANGED	-pplpshLpsplppllphht..............hhthhhp......atcEl.phlhphllhthshhp........tssohGEpahsLthhs..st.t......................................................................t.....phhsttp+hhhlhh..hlhhPYlhpKlpphhpptttpt..t..................................................................ptthhp.hhshlpsh..hphhphhphhhFlhsus......ahols.pRlhul+hshh............ttph.t...............................ssaphhsthlhhphhhphlhhhh......shh..h.hh.............s	..........................................................................ppl.shLtsplpphhphht.....................h.t..hhhp................atsEl.thhhphllhthslhp....................tssohG-phhsLphhs..t................................................................................................................................t..th.sttp+h.hhhhh.h..lhhPYl....hp+lpphhtpp...tt.tt....................................................................................................................................hphh.....hp..hhs.hlp.sh......hphht....hhphhhFlhsup............................aholh..cRlhGl+hshh..................ttphppt...............................................ssachhst..l...h.hph..h..h..phhh.hhh........hh..................t...............................................................	1	173	313	489
+3795	PF03011	PFEMP		PFEMP DBL domain	Griffiths-Jones SR, Bateman A	anon	Pfam-B_822 (release 6.4)	Domain	PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P.  falciparum [1,2].  Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes [2]. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite [3]. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains [4]. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site [5].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.34	0.71	-3.86	41	832	2012-10-03 17:31:28	2003-04-07 12:59:11	10	55	9	4	23	881	0	120.50	28	18.86	CHANGED	hFpcWVpphLcD..+h+.cKlspClpssct..p.spst..CpppCpChc+.WlppKccE.WppIKc+FpcQtchtp........................ttt.h.lpthLpph.h..shpcshsstcclp+lcchlpppttsstt...pst..s.......sppcshIDpLLp+.pccAcpCppppssps	.....................................alpph..p-h.+h+..cK..h.....c.spIN.ssp..ps..Ccss...........CpptCcsYcp.WIocK.K.p.EWDtlps+apshpsucp..................................................................................................................................................................................t................................................................	1	22	22	23
+3796	PF00365	PFK		Phosphofructokinase	Finn RD	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.75	0.70	-5.45	12	6795	2012-10-02 15:20:27	2003-04-07 12:59:11	15	15	3846	82	2001	4903	1585	268.50	35	74.02	CHANGED	K+IuVLTSGGDA.GMNAAlRAVVRpAIhpGh-VasIh-GYtGLlpG...pItplshtsVushlphGGThlGSARh.EF+pcEGRhtuhppLhcpGI-uLVVIGGDGShpGAphhppEau......................hsslGlsGoIDNDhsGTDhTIGhDoALpplh-AIDtIcsTApSHpRsFVlEVMGRaCG.lALhuGlAsGADhIhIPEts....h.p-plspplpcspp+GK+psIllVAEGshs....s..sphhcplhhpt.sh-TRlTVLGHlQRGGoPoAaDRlLAS+hGscAVchLLp	.....................................................................+IulLTSGGDuP.G.hNA.u.lR..u.l...V.......+...p....u..l....t............p........G...h...c...V..h..G...l..hc.G...at..G...L...l......ps....................ch....h...p......l......s......h............p......s...........V......s......s......h.....l.............p.......p..............G..G.T....h.L.G.o.u..........R..........h.............................t...........h...........p............p..............t............p.............s............p............t...........p............s...........h.........c.......p...........l.......c.c.............t........u......I-.uLllIGG...D.GS.h.pu......A...t...t.....L.....s...........chs................................................................................................l.s.slG..lPt..TIDN..Dl..s...u..T.....D........h........Tl.....Ga.....-T.....Alp....p....h....h.....-..u.l....D....c....l....+...s...T...u...s.............S....H....p....R...h.h.ll.E.................VMGRpsGalA...Lh.u..u....l.....A.......s.......G......u........-.......h.....l.llP.Ehs...........................hs.h.c....p...l...h...p...p.....l....p.......p.......t....h.......t.......c.......G.......+....p.......t...s........l....l.l.l.u.EGshs........................................................t...............p................h..................h..............t..................t.................l.................................t.................t....h...................................t..............h-.sRssl............L.......GH.hQRGGs..Pss..hDRhh..u......ophGh.Ahphl..t...................................................................................................	0	732	1287	1714
+3797	PF02901	PFL		Pyruvate formate lyase	Griffiths-Jones SR	anon	Structural domain	Family	\N	24.30	24.30	24.60	24.50	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	648	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.84	0.70	-6.10	129	4920	2012-10-01 23:28:04	2003-04-07 12:59:11	10	9	2399	26	529	2860	102	572.20	38	79.76	CHANGED	hh.....p............clsh....lppsh..h.ucss.l.s.........hc+shhlpctt+c.s......tGh.shs..scpspu........Ihspt.........shhI.......c-tElIVGhp.TstPhttshh....Pphuh+h.......lcst.hsh................................sapl.sppscchhpc.............htKotsctlhshastEh.......ptshcsslhT........uh.pshGtG+lhsDYc+lh.hhGlctlh.......p-tppchpphs.............................hht...hs....cchhchtcElu-p......pthpELtphAphhshs.ucP.ApshpEAlQhhaFs.aLushpEpNG.suhShGRhspaL.sYhc+Dlc.pGh...lT-cp.....AQELl-phhlKlp.lphhRssthsp.................hFuG.ss.ahshslGGhs....h-G.cshlschSahhLcsht..pl.tsspPslolhhs.pphP....csFhchssclshp..su..papND-lhh.................................hh.pD..DYu.lssCVps..h.............thG.....Kphpah...uAhhNl..uKsL.hslNsGhDph...ss......tplu.....P..ph.ssl..p..ph.hsa--lhpsacc.hcalschhlpuhNlIchhHcchs.cshh...uLh...Dsslp+shshsh....................sGlussuDSLuAIKh..........sKhhslc....c.pcu.................LsssFcsp.....................................................................................h....hPKYGNDD.....DclDplAtclsptahp.clcphps.h..R......suhhshulLolouNV.saG	...............................................................................................................p....clsh.....lppsh..a.scts.l.s..........h-+s.ht.hhc.tpp..p..........pu...shs.....sp.....hsps.....IhsptshaI....+c.....EhIVGhQ..sstP.hctshh.............P..h...u.lph.......lcpp..hs.....h.....................................................................shpl..s.chccl.ap-.............hp+Thpp...t.las..haos-h..........................................htspco..s.llo........uhss..sh..G...cG.+I...IsDYpR.lh..haGlchLh.......cctttphsplp................................................tthh....cchhcLtEElA...p...p..............hp...t....ht...p...........lhphAthhuhshppP.ApshpEAlQhhaFs.aLsshhppNG..uuhShGRhspaL..Yh.cRDlc...sGh....loEpp......ApEhl-phhhKlph.Vphl..R.ospasp..............................hF.u.G.ss.ahT.olGGhs............hD..G.......R....shVsc.SathLcolt..sh..uPpPNLTlhas.pp.LP..............tsFhchssclshp..pu..QacN.D-lhhs................................................pD..DY.ul.ssCVps...h...............hsG........Kphpaa......uAtsNl..AKslLhulN.GGhD-t........t.............h.p.h.u....................P...ph..tsl..p....s-h....Lsa-cVhpph-p.hhcalsphhl.puh.NlIchMH-+a.sa-shh...ALh...Dcsl.......tRshu.h.sh.......................s.G.lussuDSLuAIKh..............spsh.s.....lc.-.psu.................Ls.sDF-hp.........................................................................................tc...aP+YGN.s.D........-cVDsluscllcpahp.clcp..h.ps.h..R.......su.h.T.uhlTIouNVsaG............................................	0	178	334	439
+3798	PF01471	PG_binding_1		Putative peptidoglycan binding domain	Bateman A	anon	Pfam-B_2277 (release 4.0)	Domain	This domain is composed of three alpha helices [1].  This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation [2].  This domain may have a general peptidoglycan binding function.  This family is found N-terminal to the catalytic domain of matrixins [3]. The domain is found to bind peptidoglycan experimentally [4].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.50	0.72	-3.99	237	10090	2012-10-01 23:43:47	2003-04-07 12:59:11	13	329	3183	14	3243	8659	2140	56.00	25	14.51	CHANGED	psssVptlQphLp.ph.Gah...........t.........shs.....uhaustTppAlcpFQ.pthGLs.ss..GhssspThptL	..............................................................t...tlttlQ.phL..p....th..Ga.............................s...............ths............uh.a..ss....p..o.p..p.....A....l...+.pF.......Q..p.......t......t......G..........L.....s...s.....s.....Gh.h..stpThphh......................	1	982	1922	2518
+3799	PF00300	His_Phos_1	PGAM;	Histidine phosphatase superfamily (branch 1)	Finn RD, Griffiths-Jones SR, Rigden DJ	anon	Prosite	Domain	The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches.  The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase.  The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases.  The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.35	0.71	-4.14	267	22415	2012-10-02 11:42:54	2003-04-07 12:59:11	17	114	4654	228	6555	16302	6276	153.40	22	62.77	CHANGED	plhllRHGp...........op...............................s........t....................hpGpt-.............LoppGtppApthu.pt......Lp................................................shphst.......lhsSshpRstpT....Aph.lsp..............................tht........................................................h.h....tL...pEhsh.s.............Gh.htphttth..................thtthhp......t...h..................................................shtphhp.Rstphlpplh............................ttspsl....llVuHusslpsl	........................................................................................lhllRHGc.........................op................................hN..................htt.h..............................................................hp.G.ts-..................s.s.....................Lo.p.p.G..t.pp.A..p..t.hu..p.h.......Lp..........................................................................................................................................................................s.h.p.hc.t..........lh..o...S..s......h.......p..........R.uhpT.........uph...ltp...........................................ths..........................................................................................................................hs.h...h.p.....pL...........pE.h.ph....G................h....................p....uh..p....h....t...p..h..t.t..th..................................thhp.................t.h.....s...................................................................................tuE.............s.h...t.p..hht...R.h.......h.h.pphh......................................................ttppl.....llsuHusslp...............................................................................................................................................................................................	0	2047	4021	5493
+3800	PF00342	PGI		Phosphoglucose isomerase	Bateman A, Finn RD	anon	Prosite	Domain	Phosphoglucose isomerase catalyses the interconversion of glucose-6-phosphate and fructose-6-phosphate.	20.50	20.50	20.50	20.50	19.40	20.40	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.73	0.70	-6.07	10	7325	2012-10-02 15:05:26	2003-04-07 12:59:11	14	16	5754	105	1399	5509	3130	366.00	35	89.39	CHANGED	DYSKsplss-hhptLlpLAcEttlcthp-tMFsGE+INsTEsRuVLHlALRsRospslhsDGpDVhP-VstVLs+MKsFs-+lRoGsWKGtTGKslscVVsIGIGGSsLGPlhVpEAL+shsps............plaFVSNVDGTalAEsLKpLssEsTLhlVASKTFTTsEThhNAcoAR-Wlhpthst.....cuuVAKHhlALSTNspcVcKFGIDsp..NhFsFWDWVGGRYSVWSAIG.LPlALulGa-NF-chLpGAcshDcHFsooPhEcNlPlLLALlulWhsNFhGspT+AlLPYDQhLa+husYlQQLsMESNGKhVopcG.shlsapTGsIsFGEsGTNGQHuFYQLIHQGT+lIPCDFIusVpopp......chssHHcpLhSNFFAQs-ALhhGKosEEV+pEh.tu........psLlPHKsFpGsRPosSILlscLoPasLGALlAhYEH+lhVQGhlWGINSFDQWGVELGKsLApsIhscLcsuthhs.....uaDuSTsuLI	....................................................................................................................................................................................................................................................ut...s......h...h....s.........l.p..................s...hth...tt....t.tl.hputhp...h..h.s..s.p.....ps..llsIGIGGS.L.....Gshhshc.........h......L.p......htt..........................................h.ah.ssN.lsss...t..........lt.c.hl...ph...l....................s............s.........c............s............s........h....h.ll..hSK.........ohTT.E..............shhs.hp.h.+phhh.p.t...h.t.......................ttt.....h.t+.+hhAh...o.s....p..t.....p...t.....s..h....c....h....t..h.stt........ph..F...h....D....VGG.Ra.SlhoAlG.Ls.....l.s.ls.h......ts..h..p.................phLp...G.A..p.t..h..-p...c.a......t...s..s...s..h.....c.....p.....N..................h.s..h.h.h.u...h..l.t..h...h.h...sh...Gh..tschl..l.s.Yp.t............hlphastahpQh..hESpG..K....sh.p.G.........................h..s....ush.a....oss.HuhhQhl.pp...........s..phh....h-h.lh...hpp.p............................h.p..p...h..s..h..sthph.Lh...GK....s....c..h.pt.ph.....t.........................l..h..s.a....p.s......h...G.h.Ps..lhh..p.l.sshslG..LlhhaEhthhh.pGhlh........sls..sF...........c....Q.G........VEhhK...h.tlh.......................................................................................................................................	0	472	905	1183
+3801	PF00162	PGK		Phosphoglycerate kinase	Sonnhammer ELL	anon	Prosite	Domain	\N	19.90	19.90	21.80	21.70	19.50	18.70	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.33	0.70	-5.91	154	5701	2009-01-15 18:05:59	2003-04-07 12:59:11	14	18	5059	60	1467	4176	4138	364.90	46	93.99	CHANGED	olcDl.........slpGK+VLlRlDhNVPl...c..s.G.......pIoD-sRIcuulP.TIchll-p.GA+.VllhSHLGRPc........................thps.........................chSLpPV...................................AptLuclL.Gpp...VpassD..s....lGspscptltth..psG-llLLENlRFpstEp.......................cscsphscpLAsLu...DlaVNDAFGoAHRAHASshGl..sphl...susAGhLhc+ElchL.sculpsP.pRPhlAllGGuKVSsKlpll....csLlp+..lDplllGGGMA.TFLtA.pG.hslGpSL...hEp..........-hlch...................A+cllpcA.cptthclhLPsDhllu.....cc.Fst...su.ps.psssssp..ls.....ss.hhsLDlGPcTlchasch.lppA+TllWNGPhGVFE.hssFupGTtslscAlAcs....su.hollGGGDosAAlpp.hGhs-.cho..HlSTGGGAsLEhLEGK	..........................................lpDl....Dl.p.GK+....VllRsDhNVPl......cs.G.......pIT..s.Ds...RIpAuLP.TIchhlc.p.G.u+.VllhSHLGRPct................................................................................................p.pt...................................................................chSLtPV...........................................................ApcLuch.L......u.....pp.......V.t...h.....s....s.........D......s..........lG.................p.lct.hht..t..l..psG..-l..lLLENlRFppt....Ep.................................Ks-.p.huKphAu..Lu.......D...l........aVN.DAFGTAHRAHASshGl..uphh.....sus.A..G.h.LhppElchL........sc.AlpsP...pRPh.lAIlGGuKVSsKlsVlcsLlcK.....sDplllGGGMAaTFltA..p.G...h.p...lG..p...SL...hEc......................Dhl..-h.....................................................A+c.llp.cA.pt..............plh.LP..lDsl...lA..................sc.......F........u....s.......sA.......p.....s....phs.....s...sss......ls......................ss....huLDI.G.Pc..ohc...h..asch.lp........s......A.KT........llWNGPh..GVFE.hssFup.GTpslucAlAcs.........suhoIl.G..GGDosAAlp.......p.......h.......G.......huD.chS.......aISTGGGA.L.EhlEGK....................................................	1	516	944	1234
+3802	PF00408	PGM_PMM_IV	PGM_PMM; 	Phosphoglucomutase/phosphomannomutase, C-terminal domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.44	0.72	-3.97	112	12833	2009-01-15 18:05:59	2003-04-07 12:59:11	15	36	4927	56	3279	9608	4242	81.50	20	16.51	CHANGED	.lNhplsc..t..........tt...htphtphhps........................htps.phhttcGhhl...............lRsSGTEPl...lRlhhEup.sppthpphtppltph...........lc	.........................................................................................................................................t...th.t......................................htsshc.h.h.h.s..c...G...t.......hl................................lRsSG....TEPh......lR..lh...sE..ut...sp.pt.hpphhpphh....h...............................	0	1056	2051	2778
+3803	PF02878	PGM_PMM_I		Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.69	89	14497	2009-01-15 18:05:59	2003-04-07 12:59:11	11	70	4976	61	3802	11145	5249	133.00	29	27.44	CHANGED	thhFGTsGlRGhss.tp......hssphshplupuhuphlppp.......ttsplllGtDsRhsutthtpshhpslsusGlcshhhG......hhPTPsluatscp..hp......ssuGlhlTASHNPsphNG....lKhhhss.Gttlsssh.pppIpphhpphptht	.......................................................t..hFGTsGlRGhhs..tt...............hs.thshplutu.h.up..h.ltpp.........................tptpl.llGt.Ds...R.......h......s......u.................htp.slhtsL.su..s..G..l.c...V.h..hhu..........................hhsTP.sl..u..a..hs..p..p.....hp..........................ss.uGlhlT.......ASHNPhp.NG.............hKhh........s.......s........s....G.....tt..lsssh...pptIpphhpt....h..................................................	0	1252	2394	3225
+3804	PF02879	PGM_PMM_II		Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.47	0.72	-3.70	98	14085	2009-01-15 18:05:59	2003-04-07 12:59:11	11	54	4971	55	3517	10795	4847	103.50	26	21.14	CHANGED	st....Yhcpltphht.......hptp...sh......p.llhsshpGsusthhtpllpp.huh..............phht.hptts-ssFss...phPsPpt....t.shp.hhphsppp.....ss.cl..uluhDsDuDRlsls.....cppG	................................................tYlphltshhs..............h..p..h..p........s.l..........................+..lllDshsG..s.utthssp...l...h.p.c.hGh...................................plhs..lpspP..Du..sFss.............ttssPpt...........t.sht..ht....p.h..s..h....cp..................tA...D....l....GlAhDGDuDRhhll.....cttG.............	0	1142	2220	2982
+3805	PF02880	PGM_PMM_III		Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.64	0.71	-4.03	584	13734	2009-09-11 23:52:46	2003-04-07 12:59:11	11	46	4950	49	3296	10440	4816	115.60	24	23.67	CHANGED	s.....GDp.lhslhuphh........hppt..........ht.s........s..lltTlhosh.ul-cshp...p.hGh..p.hh.cotVGc+alhct.hppt.....s.......h.shGGEpS.GHhhhh.ch.....tp.....s....sDGllsuLhllplhs.........pp..s..p....slu-lh.phhpt...a	.................................................................pGsp.lhslhu.phh.....hpp.............ht.s......................s.tllpolhooh..t.lc...c.hhp...p....h.....Gh..p.....h.h.c.......shsG..a.+a..lh......c......p......hpct.................................s............h..hhG.GEpS.ut..h..hht..ch...................................sp...........s......cDGlhs...slhl.h...p...hhs...........pp..s........p..sLs-lhtph.t...............................................................................	0	1070	2094	2795
+3806	PF04608	PgpA		Phosphatidylglycerophosphatase A	Mifsud W	anon	Pfam-B_5195 (release 7.5)	Family	This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli [1].	21.00	21.00	21.50	21.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.95	0.71	-4.38	172	2384	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	2276	9	516	1528	1638	145.30	32	86.26	CHANGED	hphlut.shGsG.hh.hAP.GThGolsAlshhhhl...h..........hht.h..............hhh....hlhh.....shllGlahsstspc.ths.......hcD.utlVhDEllGhhlsh......hhh...............sh..............................h..............hh.ll......u.FlhFRhFDIhKPhPIshhD......cc................hp.............GG...hGlMlDDllAGlhAslshtlhh	.................................................h..hhuhhFssG.h...hs.P..GThGo.LAulshhhhh..............................ph.sh.....t..hhh.........hhlhhshhhGlhlsptst+..chs..........s+DcG.t.l.VhDEhlGhh.Ish......hhh...................s..........................................sh.............hh..shGFlhFRhhDhhKPhPIchhD...+p.................lc.............GG...hGlMlDDllAGlhAuhshhhh.t............	0	164	318	426
+3807	PF03334	PhaG_MnhG_YufB		Na+/H+ antiporter subunit	Mifsud W	anon	Pfam-B_3611 (release 6.5)	Family	This family includes PhaG from Rhizobium meliloti Swiss:Q9ZNG0, MnhG from Staphylococcus aureus Swiss:Q9ZNG0, YufB from Bacillus subtilis Swiss:O05227.	23.40	23.40	23.60	25.20	22.90	23.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.47	0.72	-3.93	234	1788	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1344	0	548	1242	226	82.50	33	67.13	CHANGED	hlllGuhhslluulGllR.hPD.....hasRlHAsoKusTLGsshlllushlhh........h........ptt......hsh+hlLlhlFlhlTuPlu...uahlu+AAhp	...........hlllGuhhslluulGllR.h.D......hasRhHAsoKusTLGshhlLlushlah...........spsh......................hsh+hlLhhlFlhlTuPlu...uHhlu+AAh.........	0	162	340	457
+3808	PF02304	Phage_B		Scaffold protein B	Mian N, Bateman A	anon	Pfam-B_9648 (release 5.2)	Family	This is a family of proteins from single-stranded DNA bacteriophages.  Scaffold proteins B and D are required for procapsid formation.  Sixty copies of the internal scaffold protein B are found in the procapsid.	25.00	25.00	150.70	150.60	19.00	16.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.58	0.71	-3.80	6	76	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	51	2	0	60	1	115.60	64	97.99	CHANGED	hpcNtssshopEsIpsospPQhRNEsshNsSs.pGssssT-PuGLRRDPVQpclEAERQcRspIEAGKuhCuRRFGGATCDDpSAcIaApFD.ssppVQPAEFYRFNDuElsKaGYF	.hTcNQssspSQEulQNpNpPQhRsEsAhNspuVpGshssT.puGLRRDuVQsDlEAERpKRs-IEAGKuhCoRRFGGATCDDKSApIYApFDcNDhRlQPAEFYRFpDuElNpaGYF	0	0	0	0
+3809	PF04717	Phage_base_V	phage_base_V; 	Phage-related baseplate assembly protein	Waterfield DI, Finn RD	anon	Pfam-B_5996 (release 7.5)	Family	Family of phage baseplate assembly proteins responsible for forming the small spike at the end of the tail [1]. Also found in bacteria, probably the result of horizontal transmission.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.39	0.72	-4.04	71	4590	2009-09-13 07:45:09	2003-04-07 12:59:11	7	55	1466	5	992	4204	146	90.00	34	15.09	CHANGED	Gslsslshs....p.............uR..lRVp..................sGs........h.osWl.hhsstAG..psppatsPslGEQVllh...sG..-.spulllsu.lassppssPsss	....................................................................................Gs.sAhVsu........p................hDp.GR..l+VpF.a........................t...tssc............p.Ss.WlRVup...sa......A......G...ts.......a......G.th......hlPRl.GpEVlVs....F.lsG...DP.D.pPllhGp.lYsspshsPh...................	0	209	482	739
+3810	PF03864	Phage_cap_E		Phage major capsid protein E	Finn RD	anon	DOMO:DM07502;	Family	Major capsid protein E is involved with the stabilisation of the condensed form of the DNA molecule in phage heads [1].	20.90	20.90	20.90	21.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-12.17	0.70	-5.51	77	1242	2009-09-10 22:20:44	2003-04-07 12:59:11	10	3	734	1	126	899	64	301.00	29	96.11	CHANGED	FssssLs.tsls...phs.hsshltsh..lFtp..p...s...opplsl-tp.sshhslh.shsshsssu.tht...ppptpspshpss..alt.ppslpss-ltshRsh.Gpp.............sthppht.phlsc..ch...tph.cpphchThEahphsAlts.p.lh......sscsss.hhDah.phshstts...hth....t.ts...ssh.spshpslcphpppl...phhsss..hslsusphastlhs..psplpc...thpth..t.........hp.............t..psh.patGhh..........................a.pcht................t...stph....hls.......sscshhhss.......t.shhpphausss...ppsss.u...............tshasp.h..pt.cspshplpspSsPLslsscPsslhp.sps	....................................................................................................as.tplh.th.p....ph....phpshhhpl..aFpps..........hs.hpTpplhlcpl....su.h..h.shu.shs.oPhs.tupslp....pcutps..p.hp.ss.....al.Ks+cpls.pp..h...hhRhs.sp-.................ssshphh.cllhpsh...ppt.cpulsts.Eh.sssAlh..tGK.hh........spth.p....hpl...Dh.....shstptph........t......phup..stss..h.cs.tpcl.ctht.th.......ush.sshhlhsspsap.hlps......acth+-......thcsppsu......................ttsl+.............shstsl..sa.pGhh.................lhhhpsp...Yhpp..................sG....spcp........als..................ssphllsss.........t.spGhphY.Gshp......tps.p.G...............sshYsKpa...hpss.cPstph..shspSsPL.lhs.cPsthl.lp..........................................................................................................................	1	43	83	102
+3811	PF05125	Phage_cap_P2		Phage major capsid protein, P2 family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	20.40	20.40	20.60	20.80	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.99	0.70	-5.55	5	788	2012-10-03 06:22:39	2003-04-07 12:59:11	7	2	540	0	77	634	13	308.10	45	94.81	CHANGED	RppFsAYLupLAKLNGlssscVu+..KFsVEPSVsQpLtNslQESSDFLKpINIlPVuEhKGEKIGlGVoGTIASTTDTuGsstR+spDhoALssN+YECsQINFDhalsYAhLDhWA+.FsDFQcRIR-AIlcRQALDhIMIGFNGTSRA-TSsRAsNPhLQDVAVGWLQKYRNpAPARVM....oE-sKooGKV...lls.GcsuDYcNLDALVFDusssLIDPhaQ-DPcLVsIVGR-LLADKYFPlVNKc.QcsTEplAuDlIlSQKRlGGLPAVcVPYFPAcAlhVTTL-NLSIYap--S+RRoL+ENP-KDRlENYESpN-DYVVEDYuuGCLlENIcV	.................................thssYhtplApLNuls.st..t..lsp......+FoV.EPoVpQpLcsthp-S.up.FLphI.Nl.hsVs-.pGphlslGssusIAuTs..-o.s.....s..pc.Rp.P.pc.st.l.tsp.cYcC-..QsNaDshlsY.spLDh.WAp.....a.pD...FQ.RlpstIs+p.ALDhIMIGFNGsp+A.c.sSsh.ssNPhLQDVNhGWLp+hRp.....-As.p.+VM..............sp.s....t....o....o....sph.............hts.....u......c..u.G....c..YsNLDAlVhDshssLI-.hap-Ds-LVVIsGRpLlu.schhPllN...pt....ppNoEhlAup.lIlSp+plGGL.AlpsPFFPssshLITpLcNLSIYaQcsocRRhh.h.-sPchcRlEsapShN-uYVVEDYttsuhl-pl..........................	0	9	29	54
+3812	PF05144	Phage_CRI		Phage replication protein CRI  	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The phage replication protein CRI, is also known as Gene II, is essential for DNA replication. 	21.00	21.00	22.70	22.20	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.67	0.70	-5.30	13	166	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	131	0	13	147	10	238.00	25	63.01	CHANGED	MIDalshclPhcc..............s.lshucVsplu....ssGsVEacs...spclpVsG.........SahouIul+sh...pus....s.tspLplcusPAKhhQGHNVaGo-DLpshshthapslhss.......hs-.hchlchGthplsRlDsTaShcLsocpplhuhLcuhcpsu+ppp+usts.shtoTlYFsKs..........SR+aoLphYSKt-Elp.thcs.............+ph.ctLspscLhpaAss+LRhEhpl+o+.Lpchs........lpasssapsc	..................................................................................................ls...splhphs....sst.tlpap.....tphpsps.........op.oshth+.h.........put........h.stlplcusPuKhh.QGH..NVaG.ss.....slphssth.hhstlhph..................sthhchl..s.s....tscloRIDhThshplus..c.hpphlcthpshuptpt...+sstp..s.htsTlaas.c.s..........u+ph.pl...phYsKt.sElp.pphpc......................p......tt.s.p...pp..h..h.....-.hp.t.spL.ta..u..ts..h..lRhEhph+pphLpchs..................h..................................................	0	2	6	12
+3813	PF02303	Phage_DNA_bind		Helix-destabilising protein	Mian N, Bateman A	anon	Pfam-B_9239 (release 5.2)	Domain	This family contains the bacteriophage helix-destabilising protein, or single-stranded DNA binding protein, required for DNA synthesis.	25.00	25.00	26.70	26.40	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.12	0.72	-3.96	3	81	2012-10-03 20:18:03	2003-04-07 12:59:11	12	1	61	22	8	90	1	84.70	33	88.25	CHANGED	lKVEI+sSQVuV+oRSGVS.+pGKPYTlp.EQpAYVDLGG-YPlLFsIsLDEGQPPYusGhYplHPuSFKlNpFGuLtlGR.lRLlPsK	.......................hpl..tt.th..psRshps.+pu..K..P.t.phh.EQpA....hl...hhG...Gp..aPs.hc...lpL-csQss....YssGhYplHssSa.hls.s.a...GsLplc+..h......h................	0	1	4	7
+3814	PF02305	Phage_F		Capsid protein (F protein)	Mian N, Bateman A, Haft D	anon	Pfam-B_10357 (release 5.2)	Domain	This is a family of proteins from single-stranded DNA bacteriophages. Protein F is the major capsid component, sixty copies of which are found in the virion.	25.00	25.00	70.30	26.40	19.30	21.90	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.78	0.70	-5.96	7	248	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	72	12	1	272	157	229.10	36	98.46	CHANGED	Spl.ou.hpRs.aDhSHhshpshphGcLhsI.hs.VlsGDoFphctsshhRLoshhhslhsc.plDhahFaVPpRhla.cpW.pFht-ssss..................uPhsuhspsohhDahGhsspls..sh+lsthhapuY..IaNsYFRs..h.ppstss.us.......hsts-sphs.............h+ss+h+shaTusLP.Pppthuhphsl...............................................................................................................uooulsI.uLptAhsh.+h.pccshhhoRYh-llpuahGspShDuc.pRP.hLhtosh.sss.sVstTspo........sLutFSsps..s.K+hhs+.FV.EHGhlhsLhhsRhs.TapptlchhhuR.phpa.Dhh..PsL.upLs.ptl..KEla..........tsusssthFthtEt.t.YRa+PspVssha.....psLDua.h...asshP......sLpcphl.ps.sshDcsht...Ssp.spa.sphhFNhpshRsMPshpsshh	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	1	1
+3815	PF03335	Phage_fiber		Phage tail fibre repeat	Bateman A	anon	Pfam-B_3576 (release 6.5)	Repeat	\N	20.00	5.00	20.00	5.00	19.80	4.90	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.45	0.76	-6.72	0.76	-3.45	38	2424	2009-01-15 18:05:59	2003-04-07 12:59:11	8	41	239	21	57	1692	4	13.50	43	14.97	CHANGED	susGsHsHohouss	....suhGuHoHoloss.....	0	14	30	41
+3816	PF03406	Phage_fiber_2		Phage tail fibre repeat	Bateman A	anon	Pfam-B_854 (release 6.6)	Repeat	This repeat is found in the tail fibres of phage. For example protein K Swiss:Q37842 [1]. The repeats are about 40 residues long.	20.20	20.20	21.10	20.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-7.95	0.72	-4.32	50	1985	2009-01-15 18:05:59	2003-04-07 12:59:11	8	103	486	0	146	1761	33	43.20	57	13.82	CHANGED	ohopKGllQLSSATsSsSEohAATPKAVKs.shDpAssphspsps	......ohspKGlVQLSSATNSsSE..o.LAATPKAVKA.AhDhAsu+hsspp.........................	0	4	69	102
+3817	PF02306	Phage_G		Major spike protein (G protein)	Mian N, Bateman A	anon	Pfam-B_8833 (release 5.2)	Domain	This is a family of proteins from single-stranded DNA bacteriophages. Five G proteins, each a tight beta barrel, from twelve surface spikes. 	25.00	25.00	27.70	27.70	24.00	20.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.10	0.71	-4.64	6	79	2009-09-10 23:22:16	2003-04-07 12:59:11	10	1	55	6	1	73	2	173.40	60	100.00	CHANGED	MFQpFlSKHNuPl.TSp.slusolTPAus.A..PVlsTPclou.+oslhlshTlTAuostuG.Fsasl+lDsosPssNQVlSVuAsLS.sVsuchIAslVRFEsAs.ssPTulP.uhYDsYPlE.uhtsGuuhSs+DCVTIDsHPRTsGNsVYVGlhlaSstWoAuploGllSlNQVs+EsTVLQPLK	.MFQsFIS+HNosF.hSc..lssSlTPAus.A...PVLpoPchou.pohah.ulTlsAus..uG.FhHslpMDTSsssuNQVlSVGAsluFsuDscahAClVRFESu..oVPTolP.osYDVYPl-.utpsGGhhoVKDCVTIDVhPRTsGNNVYVGhMlWSN.aTAo+spGlVSlNQVI+ElhsLQPLK	0	0	1	1
+3818	PF04688	Phage_holin		Phage lysis protein, holin	Kerrison ND	anon	DOMO:DM04726;	Family	This family constitutes holin proteins from the dsDNA Siphidoviridae group bacteriophages.  Most bacteriophages require an endolysin and a holin for host lysis.  During late gene expression, holins accumulate and oligomerise in the host cell membrane.  They then suddenly trigger to permeablise the membrane, which causes lysis by allowing endolysin to attach the peptidoglycan.  There are thought to be at least 35 different families of holin genes [1].	20.60	20.60	20.60	20.90	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.29	0.72	-4.44	24	332	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	263	0	29	157	1	44.80	42	47.79	CHANGED	GhsPlPlsEsplpphh.......SslhThssolhuWaKNN.lTp+u++ppphL.+	......GhSPIPlD--pl...........SollhslsuLashaKsNs.sopcGKhupphLK.......	0	12	20	26
+3819	PF04531	Phage_holin_1		Bacteriophage holin	Mifsud W	anon	Pfam-B_2644 (release 7.5)	Family	This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis [1].	21.60	21.60	21.90	22.10	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.79	0.72	-3.92	23	523	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	423	0	29	274	7	78.90	39	81.28	CHANGED	pINWKlRhKNKshhsAlluulhLlspplst.....hhuh..shsph.pplpsllsslhslLshlGllsDPTTcGluDSppshs.YpcP+c	.............INWKlRh..KsKshhl.ull....uAlhLhhQ.plst........hhGh....chpshspQlss...hlNulLslLslhGVl......sDPT.T..cGlu.DSp.A.p.YptP+............................	0	11	23	27
+3820	PF04550	Phage_holin_2		Phage holin family 2 	Finn RD	anon	Pfam-B_61235 (release 7.0)	Family	Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis [1].	25.00	25.00	25.50	25.30	20.40	18.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.90	0.72	-3.89	6	181	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	164	0	22	73	0	89.80	62	93.82	CHANGED	Ms-uEKolIsLhlh....GALIulGKVLsGsEPIThRLhlGRhlLGoulShlAGlALlphPDls.lALsGIGSuLGIsGhpslElhLpR+...htup	...........MsscEKSlL.SLFhI....GsLIsVGKVLAGGEPITPRLFIGRMLLGGFVSMVAGVVLVQFPDLS.sAVsGIGShLGIAGYQVIEIAIQRRhKtp..........	0	0	8	13
+3821	PF05106	Phage_holin_3		Phage holin family (Lysis protein S)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family represents one of a large number of mutually dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall.  This family includes the product of the S gene of phage lambda.	22.30	22.30	22.70	22.60	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.12	0.72	-4.02	25	643	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	434	0	62	284	2	96.80	31	90.20	CHANGED	Mscc.PchW..AslLshLpp.h...splhuuslAhlhAhLRhhY..sGssh+cpllEuslCGhlshshtssl.........pahGlssshushsGuhlGalGV-plRphspRhls+K	....................................t.h.pllshlhsth.....thhuslhAhshAhLR.hhY........sGsuhpcsll-uhhCGhluh..sltssL................c.ah....G......h.s..ps...luh..hhushIGalGs-plpshlhphhs++...............	0	6	17	39
+3822	PF05105	Phage_holin_4	Holin; 	Holin family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Phage holins and lytic enzymes are both necessary for bacterial  lysis and virus dissemination.This family also includes TcdE/UtxA  involved in toxin secretion in Clostridium difficile [1].	19.80	19.80	19.90	19.80	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.44	0.71	-4.42	57	986	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	662	0	122	758	27	117.20	29	83.22	CHANGED	lu...uhhshh..hGuhsthLhhLllhhll..DalT.GlhsA....hhp+c........lsSphGh+Glh+KlhhhllVhluthlDhhlhts......tslps.....s......llhaYluNEulSIlENhuphGlPlP...phl+phlc.pLpscs	.....................................................h..shhshh..hGshs.h.hltll.lhhhll..DalT.Ghht...A....hhptc............................lsSch..Gh.p.Glh.+Klhhh.l.lls.luh.h.lDhhlsss..................slpp....s.............l.lhFY.l.u.NE.hlSll.ENh.uc...h.G..l..P..l.P...phLpphlp..Lppc.p.........................	1	60	95	103
+3823	PF00589	Phage_integrase		Phage integrase family	Bateman A	anon	MRC-LMB Genome group	Family	Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase  (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.99	0.71	-4.59	35	44346	2012-10-02 14:09:14	2003-04-07 12:59:11	17	151	5378	81	8222	34800	8709	168.00	19	51.02	CHANGED	phLstcplppllstspp........thcs+sh......lplhhtTGhRhuElhsLchsc.lshppphhhl................psKsp+p...RtlPls...pthhphlcchltpp............tpc......................hlFssp...........tsp.hsppshppth+phstp.....sulp......thssHsLRHohuopLhcpGh.slcslQclLGHsslshT.thYs+sstpc	....................................................................................................................................................................................................................................tph....t.h..h..t......h.t........................p.....t..h.h............................h...l....h....h....h...o..G.h..R...h.......u..E.........l.....h..........s.................L......p...........h...........p...........-.....l...........s........h..........p........p.....t......h.....h...t..l...............................................................................tsK...s.p..pp.............+h.l...s.ls................pph....h.......p......h....l...p...p....h...h.ptt........................................t.p.p...........................................................................................................................h..l..F....st.................................................tt..p.......h.....s.....t....p.....s.....h.....p....p.....h....h........c..p....h...s..pp..............................ss.lp............................ph..s...s..Hs..h..R..H.o....h........u......o.......t...........h.........h.........p............p............G.........h........s............h.......p...........h........l.........p......p........h.............L.G.H......p......s......h...p....s....T....phYs+h....p..............................................................................................	0	2564	5275	6927
+3824	PF03245	Phage_lysis		Bacteriophage Rz lysis protein	Bateman A	anon	Pfam-B_3219 (release 6.5)	Domain	This protein is involved in host lysis. This family is not considered to be a peptidase according to the MEROPs database. This family Rz and the Rz1 protein (Pfam:PF06085) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway [1].	25.40	25.40	25.60	25.40	24.70	24.70	hmmbuild  --amino -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.49	0.71	-4.14	30	1696	2012-10-02 17:03:51	2003-04-07 12:59:11	8	3	601	0	80	1081	5	120.20	51	80.99	CHANGED	putphcpptschspplphsp....ssIschpsRpR........slAsLDs+aTcELu-A+uc.-sLRsDVAuG++RLp..lpA..oCsu...sspssusuulssuuusR..LsssApcDYhsLR-cItpsppQlpuLQ-YlRsp.Ch	.....................................NAlsYKtQRDcps.pc..L.c.hAN.....AsITD.MQh.RQR............DV.AALDA+Yo+ELADA+AEN-sLRs.DVAAGR...+RLp.......lpA.......sCss.......st.csTu.sSGhs.N.u.s.u.PR...LussA.....ERsYatLR-tlhphppQLcshQ-YIRoQC..........................	0	7	26	55
+3825	PF00959	Phage_lysozyme		Phage lysozyme	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family includes lambda phage lysozyme and E. coli endolysin.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.47	0.72	-3.77	18	3255	2012-10-03 00:09:25	2003-04-07 12:59:11	14	30	1340	658	411	2608	736	110.60	29	59.84	CHANGED	hhTIGhG......pspslssp.t..................hopppusshhphslp.thtctlsphhp...........shstsphDAlsshsaNhGht...........hhttoohlcthpttphhttssplhc.h.s.G.......phhptlhpRRpp	....................................................hhTlshG...............sspslhsuhp........................................hocpps.stl.h.....t.h.-ht..ps...t.....h.l.p.p..h..lps..............hs.p.pt.s.u.ls.hsaNlGs.................Gth...t.sS.T........hh+.+...l.N...t.........G.....-..h..p..u..A..C....c..p....l.......h.t.W.h.h..s...sG.............pth..h...GhhpRRc.............................................	0	74	208	308
+3826	PF03863	Phage_mat-A		Phage maturation protein	Finn RD	anon	DOMO:DM08200;	Family	\N	25.00	25.00	25.70	25.70	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.33	0.70	-5.41	11	306	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	19	0	0	219	0	218.90	48	94.72	CHANGED	aaPcchht..hslplspYthsthhssp..hpthss..hhph...poPcphs..........sPssah.GhcslTslch.ssshhhph.sssscas.upusuuslchpsal..ss..........hhuphsashpsphsschtschSthssphGshluEuRcTlphLuhhhtplhcua+Al+RGDl+cltphlp.h...............................pptcapupssushWLEhpYGlhPLhhDIpushE.......-ah+sHtchthhhRhSsshGpshslphsth.Puhshh...slpspsslpRR.........pthahshssupLt.lS.....uluhlNPhpluWElsPaSFVVDWFlNVGchLEth..phhhslchlsG.hsp+clch+Sl.ol+shhssss.............shp.upspshtshhsRshpsshPpssstlcoshush.HllDulALl..sQRlK+	.......................E.sassolhsYscstp.sNuaShchhsN..........aTPtRhs......+pa+hPosaSpGhhsVTol-Q..GAapRphSshGRsa-.tsGhuhoLcsc.....us.phhs.s...hhh.hs.shssp.......................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+3828	PF04233	Phage_Mu_F		Phage Mu protein F like protein	Kerrison ND, Finn RD	anon	COG2369	Family	Members of this family are found in double-stranded DNA bacteriophages, and in some bacteria.  A member of this family is required for viral head  morphogenesis in bacteriophage SPP1 (Swiss:Q38577).  This family is  possibly a minor head protein. This family may be related to the family TT_ORF1 (Pfam:PF02956).	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.41	0.71	-3.55	13	1923	2009-09-11 06:39:01	2003-04-07 12:59:11	9	14	1455	0	257	1607	203	114.20	19	30.44	CHANGED	pplpssltpultpGpshcclu+pl+ch.................................th.s+tRhphlARspstps.sAuphtp..pptphtht.h..pasustDsRsRspHtcLcGpl.....aphD-..hp.sst.............PspchNCRCslh	.................................................................................................t..lpp.lhpul.h.p.G.p.....s...p..phtcplptt..................................................................hth.sp..c...h...pplhcTphsp.s...hs.tuphpp.......htph.sh.....t....h.....h....p.a.hu.....s....h...D.s...+...s....p...........p....t........p.....t..s.h.....c..G..p.h.........ac.....hc.-.sh.h.t...hth...........................................................P..s..p.......h.sCRCph.h..................................................	0	81	168	215
+3829	PF05136	Phage_portal_2		Phage portal protein, lambda family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.1);	Family	This protein forms a hole, or portal, that enables DNA passage  during packaging and ejection.  It also forms the junction between  the phage capsid and the tail proteins. 	26.30	26.30	26.60	26.30	26.00	26.20	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.98	0.70	-5.92	62	1366	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	672	0	152	1135	323	316.40	34	69.92	CHANGED	ustspphtsWpstst..ussstltt.shsplpsRuR-l.s+NsshusuulcphhsNllG.sGlp.p.tths.................spthpcplcphW.ppWs.ss...psDssGphsahthpplshRshl.psGEshsphhhtpts......shhhshplpll-sDpls...ssh...........ssss..p.......lptGlEhcphG+.lAYalhcs+Pssshht...........phpRlPAp.......pllHlac..pRsGQhR.Glshhusslh+lppLcpap-ucLhptcluAhhuuaIcpspss.ssshtt.ss........................t.ptpt.hplpPG.thttL.PG--lphhssscssssassFhpt.LRslAuGh.GlsYctlotDhssssYSShRtullEhp+thpthpp	.......................................hssphtta.s.sp..osDstlh..shpthpsRAcsL.scNsshussulphhp-+lVG..ph..hhlp..htss.hphh.............AcshscclcstW.pEau.s......h.DVpu....phTas.h.R.sltsah.hsGElFsphshspts......sthhthphchlpPchls.ss......................stus..............lptGV......pls..c..h..G.cshuYalhc..st..st.h.t............chpplstc.........phlHl.h.ps..h.cssQhR.Gs.s.hhuVh.plphLcphpsspLpuAhltAhh.ushIcpt.ss..ptshch.ts..............................................h..s.tt.l...pl.sG.htlscLhPG-clph.su.pcssssapsFcpu.LRhlAAGh..slSYpplu+sast.oYSutRtuhsEuhchahhhpc.............................................	0	47	88	121
+3830	PF05133	Phage_prot_Gp6		Phage portal protein, SPP1 Gp6-like	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This protein forms a hole, or portal, that enables DNA passage during packaging and ejection.  It also forms the junction between the phage head (capsid) and the tail proteins. During SPP1 morphogenesis, Gp6 participates in the procapsid assembly reaction [1,2]. This family also includes the old Pfam family Phage_min_cap (PF05126).	24.50	24.50	24.70	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.23	0.70	-5.92	56	1289	2009-12-18 13:44:14	2003-04-07 12:59:11	9	4	997	13	170	1119	57	413.50	14	90.04	CHANGED	pscpltphlpcphtpppp......h..hppYYpu...p.chhppttt...............t.hthcp+hshsaschllcphsshhhspshphsts.....sp......pssctlpchhp...tNchcsptpplhpsshhaGtuahhhahs........pssp.....hchth..hssppshslassshppp.hshlphhpppspptht...............................plasssp..........hhhhphpss...thh.t.stttt..........................astlPlltasN.sc.p.....puch.cshhsllDshscsh..sphsschpshs.chlhsl........................hs...........................t.ttphhpshpptphhpl.................sssssschlp......pphsssshcshhctlcp.lhphutssshs.spthu.....ussSuhAlchthpthppcsppppppappulpchhphhhphhs.....tps.h...........clphsascsh.tshsppsc......sthtt...tGhlopc..shlpths.........hl......s..-scpEhc..chpp-ptphtptttsttp	............................................................................................................................................t..........................h..h.paaps...........p.phh.t..t................................h.s...p+hshsasphlscthssh.h.h..s..p..s.hphsts.............pp...........................ph..pt....lpphhp...........ts.p..h..ppt.p.phhppsh..h...hG.tu..a..h..h..h.hhs.....................ps..sp.......................hplph.........hss...p......p..h...h..sl.h.s.s.p......p.p.p.....h..h.h.lph...hp...p.p..t..t.pt.t...................................................pla.sss.t.............hh..h.h..hp.tt...............thh............st..t.......................................................hsh.lP..l....h...h.s..s.....c.p..............................huph.cphh.sllDthspsh.....uphss..p..h.p.th..t...phh.h.sh.............s........................................t.ttp..h.p.p.h.t...ptthhpl.......................................s.tss.ss.phlp.............tph...s...s.tth.c.shhc.tlp...p.lhphsttsshs..spphu.............ustSu.u.....hc..hp..h.shptpsppppphhp.p.ulpp.h...h...p.hhhp.hhp.......................t..............................plp...hpas...p...s..hshshtpth...p..........shht.......tGhlop.c...ph.ht..h................hh..............s..cs.p.tthc.....chppct...........t...........................................................................	0	61	125	149
+3831	PF05135	Phage_connect_1	Phage_QLRG;	Phage gp6-like head-tail connector protein	TIGRFAMs, Finn RD, Bateman A	anon	TIGRFAMs (release 2.1);	Domain	This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97 [1]. A structure of this protein shows similarity to gp15 a well characterised connector component of bacteriophage SPP1 [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.32	0.72	-3.84	81	1873	2009-09-11 08:37:08	2003-04-07 12:59:11	8	5	1271	14	232	1181	124	94.80	16	85.42	CHANGED	Ms.......................Lc......clKphLpl..-sspcD..sllpthlp....sApphlpsthsp.....................t.pphssthphhlhtlss.phap...p+ss..pupss........p.hsh..shpshlspl+th	..................................M...............LcclKthL+l....-psp...-D....chL.pt.hlp....sApphlp...s.hhst.......................................................................................th..sthph..s...hh.lss.hhYp.......ppt..........st.t............................h...........h............................................................................................................	0	72	146	194
+3832	PF04492	Phage_rep_O		Bacteriophage replication protein O      	Kerrison ND	anon	DOMO:DM04335;	Family	Replication protein O is necessary for the initiation of bacteriophage DNA replication.  Protein O interacts with the lambda replication origin, and also with replication protein P to form an oligomer [1]. It is speculated that the N-terminal half interacts with the replication origin while the C terminal half mediates protein-protein interaction (annotation of Swiss: P14815).	28.70	28.70	28.80	28.80	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.04	0.72	-3.80	9	670	2009-09-11 22:41:49	2003-04-07 12:59:11	8	3	446	0	27	476	7	97.40	48	35.34	CHANGED	phhEpR.....hADL-DGYhRlANpll-uhhtscLotRph..pVlhAlhR+TYGaN........K.hDhlsNsQlAplTs.......lssp+lscAhppLlccsll...ppsG.+hlGhNpslSpW	................s...E.p..VADL-DGYsRluNtLlEAhhhusLTp+Qh..pVhLAlhRKTYGaN...........K.hDhlossQLuElTt.......l..s+.+C.spAKppLV+hsIl.............hQpG....t.hGhNpslSEW....................	0	7	8	15
+3833	PF04984	Phage_sheath_1		Phage tail sheath protein	Bateman A	anon	COG3497	Family	This family includes a variety of phage tail sheath proteins.	26.20	26.20	26.20	26.40	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.39	0.70	-6.05	41	3025	2009-09-13 02:25:27	2003-04-07 12:59:11	9	6	1415	24	555	2645	2611	301.10	16	92.64	CHANGED	M...s.....tsphhPGhYlphpssuttshshuspGhluhss......shshGss.....spshpl.ssts...phhphhG..........hssphhthlcthhp.tsstplhlh+l.st....................Gspsssph...........................................................................................................t..hhtshhsGtpustltlhl..phstt...................................hshhh..ts..h............l.sp...........thh.....t.s.ht....................sstsltuGss..suthss.chht..........shssh...pshphshlshss.......tsp..slpssltshspphptt.ttcthullss.ss..s.......t...................-thhslssthshhsss.ht.............sssalAGhtAt.sshppuhss......hphsuhhslshp..hspsc....hpthlpsGhhshpts..ssslplhpslsohhp.s.tspspsatp.pslRshshlppsltpthpp.hhsctss......sc............sshtslpssltsah.cpLpstGslp.sacs......ptDhplpt.......................sscpsclhhphshpsVsshcplhhshplp	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.......................................................................h.......................thhh.hs...........................................h........h............................h.....hhs..h..hs......................................................................................................................t..h..........t..........h....................................................................s...hhhuhh.......uh...s....t.....s..................................t..........h.....s.......h...h..s...h..................ht........t.p................t..........h...............t.t....l..s....shh...........................t...t.h.h.h..t...shs..................s...h.....hhchhthl..p.tht...h...........hh............s......................hhttl..t.hh..tth.t.t..hl...shp...................t.....p...............................t.t.sth.h.h...t.....hc.h.h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	146	338	468
+3834	PF04630	Phage_tail		Phage major tail protein	Mifsud W	anon	Pfam-B_5341 (release 7.5)	Family	\N	20.70	20.70	20.80	21.20	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.01	0.71	-5.22	14	370	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	319	0	29	212	1	175.60	25	78.65	CHANGED	MA...ohGlctltluLlDspsshlh.cussGL.........ossGla.hDs....pshGTpTANITsLpuussplaGNNpltcsshupupPpVAhshNsLsa-lppKlhGhhsDscGGYs.ps..pKP.+VAlLlpS.pslDpsp.lYauFusGphsE.outNhsTss.supsRs-DslTasuLs.........pshsspshKha.ss-.................ssFs.pssMhp-VFsGYstsss	....................................................t...............................................pt....p..u.shphplosltsp.hscha.usN.t.lhh.t.t....pGsuclpschshhs.lP...s.-.shspllG.t.p.ccp..s.G.shh.hup...pspP.saVull.hEo..c.stsss.shaluLhKGpFoh..suhchpT..cp..cs..s..pss.plohphhs................t.tt....hh.h.h...t..t....................t...t...............s.......................................................	0	11	19	26
+3835	PF05100	Phage_tail_L		Phage minor tail protein L 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	25.00	25.00	25.40	25.20	20.00	23.20	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.43	0.70	-5.20	8	1425	2012-10-02 17:50:33	2003-04-07 12:59:11	7	6	613	0	63	1256	146	186.40	62	86.69	CHANGED	TshGu.-hhhFps...............E.pttGt........PlsWQGppYpsaPIpupGFEtsGcGousRPoLTVuNLhGhlouhspshssLVGApVlR+cTYA+FLDAsNFssG.NPsADPpQEh.lshWhlEQpot.su.posoFlLSoPs-hpGshlPuRphLusoCsWs....YR.G-sCGYsGsshhDcaspPToDsutDcCo+slouC+hR..ahtsNllsFGGFsuss+l	............................................T..GG.ERYFFCN................E.NE.K.GE................sVTWQGR.pYQsYPIpGoGFEhNGKG.ousRPoLTVSN....L.........a.........G........h......V.TG....M.AED......L......QSLVGuTVVRR+VYARFL.DAVNFV.sG.Ns..-....ADPE..QEl..hsRWhlEQhS-LoA..hoASFVLuT.PTETDG..AlFPGRIMLANTCh.....Ws..............YR..GDECGYs....GPA.VADEaDpPTo......Dl.p...K..................D+CS.KCh.p.GCchR...........s.s......l..sNFGGFLSINKL..................................	0	5	25	45
+3836	PF04761	Phage_Treg		Lactococcus bacteriophage putative transcription regulator	Mifsud W	anon	Pfam-B_3898 (release 7.5)	Family	This family represents a number of putative transcription repressor proteins found in several Lactococcus bacteriophages. Horizontal transfer may account for the presence of similar proteins in Lactococcus [1].	25.00	25.00	54.90	54.80	21.90	16.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.90	0.72	-4.20	2	33	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	27	0	3	26	0	56.50	75	97.85	CHANGED	M..EpslsHhGpsl.QcSVEaYKcpL.hc.ShpFlpsSLlPQLaEWSNAYKAAVELTK	....MpQEKTINHLGQlVYQESVEFYKEKLSVa.SKDFLQNSLIPQLYEWSNAYKAAVELTK..........	0	2	2	2
+3837	PF04985	Phage_tube		Phage tail tube protein FII	Bateman A	anon	COG3498	Family	The major structural components of the contractile tail of bacteriophage P2 are proteins FI and FII, which are believed to be the tail sheath and tube proteins, respectively.	22.40	22.40	22.60	22.50	20.80	22.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.73	0.71	-4.81	53	1069	2009-09-11 14:55:36	2003-04-07 12:59:11	9	6	755	0	146	654	22	163.70	38	97.85	CHANGED	slP+.pL+phNlFsDGpuahGplpplTLPKLstKhE-aRuGGM.sGslclD..hGh..-tL-sphshuGh.pt-llphaGhsshsustlpFpGuapppc.....upssslplshRGchpEl..DhGshKsG-csphphohssoYYKlsl.sGcsllEIDhlNhlptlsGsDhLus.hRpslGl	....................hlP+.+L+hhNlFh.D.G.p.shhGhlpslTLPKlocKh-pYRGGGM.sGuls..lD..hGL..sAL-spashuGh.pttlhpta....Gtssh.c.u..l...LRFsGuhpp-c.......u-s...s..lElhh...RGRhpEl..Dh.G-h..Kp.G..Es.s.ppphs.h.s.s.o.YaKLol..sG..csLhElDhlNh..l.h.l.sGsDhltp.hRsslGL.................................................................	0	28	72	114
+3838	PF05155	Phage_X		Phage X family   	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.1);	Family	This family is the product of Gene X.  The function of this protein is unknown.	20.80	20.80	21.00	20.90	20.10	18.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.82	0.72	-4.05	18	179	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	139	0	15	160	7	88.90	29	24.99	CHANGED	shsphuspphschspthphhhthWppG.scl+shl...s+uTFaRacpcLhphGlDhuph.sls+tsss.hlPLs+lL-scss......phP-WYhpPshhhs	..................hs.tGshshs+tsphhphYhhLhppG.psl.+t..th.........s+soaaRahpc.Lh.phG.lshuph.slschps...lPhschlphc.s......phPs..aYhcPs....s...........	0	2	8	14
+3839	PF02912	Phe_tRNA-synt_N	tRNA-synt_2_N; 	Aminoacyl tRNA synthetase class II, N-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.00	21.00	21.10	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.12	0.72	-4.25	53	4298	2012-10-01 23:07:44	2003-04-07 12:59:11	13	4	4261	7	933	2788	1981	72.50	33	21.23	CHANGED	tpApshcsL-plRVcaLGKKG.lTplh+sLGsL.ssEER.thGthlNps+pplppslsp+cptLcputlst+Lt	...................p.tAsshpsL..cplRVpaL.G.K.K.G.plT.thh+s..lt.sL.ssEERsthGthlNps+ptlppsls.....t+pptLcpttlpt+Lt................	0	317	621	796
+3840	PF02332	Phenol_Hydrox		Methane/Phenol/Toluene Hydroxylase	Mian N, Bateman A	anon	Pfam-B_15166 (release 5.2) & Pfam-B_3223 (Release 7.5)	Domain	Bacterial phenol hydroxylase is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This Pfam family contains both the P1 and P3 polypeptides of phenol hydroxylase and the alpha and beta chain of methane hydroxylase protein A.	24.40	24.40	24.40	25.90	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.55	0.70	-5.06	23	1141	2012-10-01 21:25:29	2003-04-07 12:59:11	13	3	362	190	164	1148	22	186.10	33	63.63	CHANGED	sWs.papppcs.......ttpsl+hscWpsacDPhchhYtsYVphpscp-ststu.lhsuhscs+thpph.sstat.sphptth.sslphsEauA.hupuph.schu..husshpssusa.tshDcl...Rahphphhhhcchstps.phshup...+thaps-.uhpuhRchh--hhh.stDhhEshluhshsh-sshsshhahtL.sptAspsGDpshuhLhsuhpsDpsRHsphusshlphhlppstp	.......................................................................pttpppt..u.hh-uhspssu..th.cscah.pshKhhh.sslp.hEYtAhtu..u.hl.scph..sussh+suh.h..QslDEl...RHsQpphah.pta.t...pt.hshhp....pcha.sps.hhpss.+phF-Du.h.oussh.E.h.h.hu.lshshEhllTNlLhVsh.hphAAhNGDhsTsThhhSs.p.o.D.E.uRHhshGhps.lphhlppt..s...................	0	56	115	147
+3841	PF04663	Phenol_monoox		Phenol hydroxylase conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4509 (release 7.5)	Family	Under aerobic conditions, phenol is usually hydroxylated to catechol and degraded via the meta or ortho pathways. Two types of phenol hydroxylase are known: one is a multi-component enzyme the other is a single-component monooxygenase.  This region is found in both types of enzymes [1,2].	18.40	18.40	19.40	19.20	17.60	18.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.38	0.72	-4.23	25	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	72	6	28	84	3	66.00	43	56.72	CHANGED	s+DphENFpGtpLLYluW-cHLhFCAPhsLPlPPshPFGsLlppVLsssautHPDaA+IDWspspWh	.....+Dtp-NFsu..LLYlGW-cHLhFCuPhshPlPPshsFusllppVLsssautHPDFA+IDWuplpWh.......	0	4	17	26
+3842	PF04674	Phi_1		Phosphate-induced protein 1 conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4596 (release 7.5)	Family	Family of conserved plant proteins.  Conserved region identified in a phosphate-induced protein of unknown function [1].	25.00	25.00	35.00	32.20	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.02	0.70	-5.23	21	304	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	33	0	177	296	0	240.80	43	84.05	CHANGED	LpYHpGslL.sGsl.oVsllWYG+FsPsQ+ullsDFltSL.....Suss.............sssP..SVAsWW.+TscpYhptsssphs.......sslsLupQlhDpshShG+pLoctplppLAucu..u........tpsulslVLTusDVsV-sFChupCGhHutohsuhhth............phsYsWVGNStsQCPGpCAWPFHQPhYGPQus...........PLsuPNGDVGlDGMVhsLAohLAusVTNPauNGYYQ.GsssAPLEAAoACsGlYGsGuY.PGYsGpLLVDtsTGASYNAsGlsGRKaLlPAlaDPsoSsCsTls	......................................hpYHtG.s.lL...s..G..s....l.sVpllWYGpasssQ.......+..u...lltDFltSlosss.............s.tP...SVupWW.posp.tYh.ttsttt..................tplhlu..tph......Dp.th.Sh..GKsLpp.pl.plstpu..s...............tp.sulhlVLTutDV....s....V....p........s..........FChuhCGhHs.s..hs..u........................phsYsWVGNutpQCPGtCAW.PFt.tP.h..Y..G..Ppss.................sLhsPNGDVG..lDGMlhslAphLAsssTNP..as.suaa.p...G.......sssAP........lE............s...sssCsG.lY.GpGuh.s.GYsGplhsD.soGASYNs.Gh.pGR+aLlPtlasPtspsCts......................................	0	30	114	149
+3843	PF03831	PhnA		PhnA protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	23.00	23.00	24.00	24.40	22.00	18.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.70	0.72	-4.56	104	2536	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2436	2	438	1315	90	55.40	62	47.32	CHANGED	hh+DuNGshLp-GDoVolIKDLKVKGoShs.lKpGTtV+sIRL...st..sssccI-s...Kl-...G	.......hl+DANGNlLsDGDoVTlIKDLKVKGoS.ps.lKhGTKVKNIRL.....V....-GDHsIDCKIDG.......	0	121	255	351
+3844	PF02562	PhoH		PhoH-like protein	Mian N, Bateman A	anon	COGs	Family	PhoH is a cytoplasmic protein and predicted ATPase that is  induced by phosphate starvation.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.32	0.71	-5.09	164	6190	2012-10-05 12:31:08	2003-04-07 12:59:11	11	24	4026	2	1327	5544	4974	200.10	47	57.55	CHANGED	sI+s+ThsQppYlculp...ppD....lsFGlGPAGTGKTYLAVAhAVpuLpp..pcVcRIILoRPAV.EA...GE+LGFLPGDLp-KlDPYLRPLYDALa-hl........................sh-psp+hh..EcshIElAPLAaMRGRTLscAFlILDEAQNTTspQMKMFLTRlGhsS+hVlTGDlTQlDLP.ps.p.....pSGLhcAhclLcs.lc..uIuhsphsppDVVRHsLVp+.IlcAY-	..................................................................................................s.I+s+s.sQp.t.Y..l...p.slh.......pp-......llF..ul.GPAGTGK.T..........a.....L..A..l.....A..t.Al..p.A.L...pc......pp...l..c.....R...I..l....L.T..R..PAV....EA.............GEc..L.......G..F..L.P..G.D..l.p.....E..K..l..-.....P..Y...L......R.P...l..Y....D.....u..Lhph..l....................................................................u.h..-..p...h....p..c....l....h...-...+.....s.hI.E.l.......A..PL......A......Y...M......R...G.....R..T......L......s...c......AF..lIL.DEA.QNsThpQ......MKMF....LT.R.l....G..h.s..S...KhVl.......oGDl.o..Ql.DLP..ts..h...............pSGLtp..AhchLc..s...lc..........tlua.sph...p..t.pDVVRHslVtcllpAY........................................................................................................................................................................................................	0	436	867	1125
+3845	PF02114	Phosducin		Phosducin	Mian N, Bateman A	anon	IPR001200	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.53	0.70	-5.67	2	1240	2012-10-03 14:45:55	2003-04-07 12:59:11	11	6	686	7	485	1332	19	169.10	36	84.47	CHANGED	ht.ApSpo...hE.shEG.uspTGPKGVINDWR+FK.LEoEpp-p.s+phccll+phS...........pppcpKD.pE+hStKMolpEhthhcKsh-DEphLppYR+QpMp-M+QpLphGPpat.VhEl.SGEtFL-hI-KEQK.ThIhVHIYEDGl.Gs-AhNushICLAAEYPhVKFC+l+uSshGAusRFopssLPsLLlYKuGELluNFlpVT-QLuE-FFssDlEuFLpEaGLLPEKEhhVLppsp........-pDhE	..........................................................................................................................................................................................................................................................................................................l....p..t..-..c.E..D.E...p..h...L..c...p.....YR........c.+pMp....-h........+.......p.....c......L.......s..........h.......s........s.....+..........a.....G......p.....l......t.........E...l.......p...........s............G-................pFL..........-...s.....l....................E.......................+.......p.......p........K..s...s.................s....l.......l...VHl..Y.-..-..u......l...p.....s..Cc..l......LNssL..s....s..L.As.cY.s.h...V+..FCK.I+.A...s.s...s...s.....s.t...........-+....Fss...cs..LPTLLVY+.s.G...-LlusFl...uls.-..ph..............................................................................................t............................................................	1	154	244	369
+3846	PF00068	Phospholip_A2_1	phoslip; 	Phospholipase A2	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.18	0.71	-3.86	37	1645	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	315	390	515	1676	0	114.20	33	69.11	CHANGED	NLhQFtpMIppss..Gppshh.pYssYGCYCGhGGpGoPhDshDRCChsHDsCYucs.p.sGC.....pP+hstYoYpppsGs.lsCss.pssCpptlC-CD+sAAhCFups..sYN.pphh.....shsp..sc+C	................................lhphtpMIpphs....sp...pshh....p.....Y...tsYGC....YC.............G..........h...........G........G........p...........G.......p.....P..........hDs.....h..D.+CChs..HD..sC...........Ys........c..s....t...........t......ps.C..............pP...p....h.s.t..Y....s....a......p...h..........p........s...............s.......p.......lh......C........s..........s......p..........s........................Cpp.lCpCD+t.uAh.C..h.tps......sYs.pp.hh................................................	0	195	222	307
+3847	PF04185	Phosphoesterase		Phosphoesterase family	Bateman A	anon	Pfam-B_1803 (release 7.3)	Family	This family includes both bacterial phospholipase C enzymes EC:3.1.4.3, but also eukaryotic acid phosphatases EC:3.1.3.2.	20.40	20.40	20.40	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.43	0.70	-5.26	20	2105	2012-10-03 20:55:17	2003-04-07 12:59:11	9	30	757	2	743	1807	98	335.40	23	58.08	CHANGED	lcHlVllhpENRSFDHhaGphsssps............................st.h....h.....s..stt...sh.p.sa...s.t.s.shhsu.h.ps..Hth.t.t.thstGh.tD.h...........shs.shsMuhaptpclPha.atLAcsFslsDpaFsSl.GuTpPNRlalho.uss.....................cssGs................................................puss.ls.st..........tsashpshs-pLppsGloWslYppthsssh..............h.sh...................................cthhtssthtphthssFtpDlcpspLPpVSalhs.......sssps-...HPuass..tGspalspllcsLtusPp.WscTlllloYDEsGGaaDHVssPsssh.s..sthh.............s..s...........ht.hGLGsRVPshlISPa..s+sGhlscp.........paDHoSlLphlcppFs....ls	............................................................................................................................................................................................................lcplVlhh.EN+SFD.......phhG...h.....ssps............................................................................................................................................................a...............................................t...........h....t....................h.....t.....t..t....h..t.t...uh....s..............................................t...shsha............p..t..p..p..hPhh..hsL....AptaslsDsaa...........s....uh.....hs......sotP.N+.hhhho.uss..........................ss..t..........................................................................................................ss.ss.h...t....................sh..s.hp.s..h.s-...tL...pp..s.....G.....l.o.W...t..hY.t.pt.....h...........s....s....h......t.............t..................................h..........h........................h............t........................................................................................................................tt.t.h.s..t.th.....t.....h.....h.s.pFht.clt......s......s..p..L.P.p.V..oa..lhs......................sts...st...............H..............P..........s.............s..........s............................st........G........s.........h........altp.......ll.pslp...psPp...W..p....c....T....slllsaDE....s.s..G...a......aDH..V.s.s.s..h....ss.........................................................................................ht..G..R.lPh.hll.SP..a....s+s....Gh.Vspp.....................ha-HsSlL+hlcphaul....................................................................	0	244	433	617
+3848	PF04272	Phospholamban		Phospholamban	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation [1]. Phospholamban is thought to form a pentamer in the membrane [1].	22.40	22.40	22.40	95.30	21.10	22.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.79	0.72	-4.52	2	32	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	28	15	20	25	0	52.00	90	96.41	CHANGED	MEKVQYlTRSAlRRASTlEhs.QARQpLQpLFlNFCLILICLLLICIIVMLL	MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL.	0	1	1	4
+3849	PF00922	Phosphoprotein		Vesiculovirus phosphoprotein	Bateman A	anon	Pfam-B_1160 (release 3.0)	Family	\N	20.50	20.50	21.70	21.50	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.80	0.70	-5.19	5	426	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	22	22	0	209	0	151.00	51	89.39	CHANGED	oR...LpphLKsYPcL-sTLu-I-EhE-ppc-cssp..FpsDusscsopPSYYLu--hc-S-oEsssEDspsl.splPPsspVE.a.ts.spDshhDDDl.....sVsFs-c.sWosslpKsssG+tsLcLouPpGLTstQhsQWpcoIcAls-pSKthRLupspIcsou-GLllpER.MTPslSsoo...................-.hPsSssSssoopslS.......o.posoPuspSssS...LGLP-lsus....uhh.+EhpLsPlsuSssPYcsTLs-LFGSp-ualsYsssGshSLK-AlIuGLK+KGIYN+IRI	.......................................................................................................................................................................................................P.GLot.QpsQWhhTIcAVspSuKaWNLuECph.sSs-slIlKtR.hTPDs.pss.......................h.psps.pSEulS.........................slWsLppT.........shphpsK+AulpPLTloLc-LFuSctEah.hssptt.p.hthhlhGl+h++LaNp..............	0	0	0	0
+3850	PF00343	Phosphorylase	phosphorylase; 	Carbohydrate phosphorylase	Finn RD	anon	Prosite	Family	The members of this family catalyse the formation of  glucose 1-phosphate from one of the following polyglucoses;   glycogen, starch, glucan or maltodextrin.	19.00	19.00	19.10	19.00	18.60	18.90	hmmbuild  -o /dev/null HMM SEED	713	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-13.21	0.70	-6.65	9	4954	2012-10-03 16:42:30	2003-04-07 12:59:11	15	27	3182	252	1289	3940	903	590.10	40	79.46	CHANGED	ALhpLGlsLEELhEpEpDAGLGNGGLGRLAACFLDShATLsLPuaGYGlRYcYGhFcQpIscGtQsEhPDtWLchGsPWEhpR.-hphsVcFaG+Vp....psupt..hcW.psphlhAlAYDhPlPGYcssssNolRLWSA+s.sp-FNLscFNsGsYlsAlpp+ppuENlocVLYPsDsphpGKELRLKQpYFlVuAoLQDIlpRaKpsc........psasshscKVAIQLNDTHPsLuIPELMRlLlD-EphsW--AW-lTs+TFuYTNHTlLPEALE+WPVcllcpLLPRHhpIIaEINcRFLptVtppaP.sDhc+hcphSll-E......t..+pV+MAaLslVGSHsVNGVAplHS-llKpclFsDFhplaPsKFpNKTNGITPRRWlthsNPuLutllsctlG.-cWhssL-.LpcLcpasDsstFhcphtplKptNKh+LAcaltpchsVplNPpuLFDVQVKRIHEYKRQLLNlLHVIshYpcIKcsst...tphsPRssIhGGKAAPuYahAKpIIKLIssVA-VlNsDPtVsshLKVVFlsNYsVSlAEhlIPAuDlSEQISTAGTEASGTuNMKFsLNGALTIGTLDGANVEItEclGc-NhFIFGhps--VpplcccG.YcspcaaptDscLcpVlppIpsGhFuP.psctFcsllsS......l.asDhYhVhtDFtuYl-sQcpVDphY+spcpWsctuIhNhAssGhFSSDRTI+EYAccIWslcP	....................................................................................................................................................................................................................................................................htthsh.s.lpcl.-.........E.DsuLGNGGLGRLA...A..C..FlDS.hAolshsuhGhGlpYcaGhFcQth....s..G.QhE...P...-.W.....h.p........t...sW...h.c.....p...........hth...V..ta.h.G..h........................h......lhu.saDhs.......lsG...Yps.t...s.spsLRLWpups....t...h...s.h..t..Fs.t.G...t....a.tu.tpt..scslotlLYPsD.sp....tG+.L.RLhQpYFhsusslps.Ilcca.h..t..t...........t.sh.p..ph.s-..h......slp.lND..THPs.lu.IPELh.Rl.L.....l.D..pct.hs.W..-c..Aapls..pps.......huYTNHTlhsEALEpWslphhpp.lL.PRhh.p..II.cI.s.pp........ah.t................l.p.t.....p..h....s.....s..s...........t....h...h..tp..h.ull.c.-.................................s.....t.p......V+MAhLsl.hsu.a.pVNGVutLH...oc...l............l......pp...sh.h......t.c..a...h...p....l.....a.....P.....p......+......F..p......N......h......TNGl.........T...........R.....R..................W..................l......................h...............s...NP.........tL......u..t....l.l....s.................c................t.......l...........G.............c........p........W......h.........p.....-...................h.................s..............p..............L...p.....p........L...........p....p.........a.........s.............-.....c..........s...........t....h......t.........p.......p............h........t...p........l.......K....................h.........p............N............K..h...........+......L.........A.....p..........a.....l.........p.........p..............p..............h.................s...............l..........p.................l............s....P.....p............u.............l.....F.........D......l............Q............l......KRlHEY.KR.QhLNh..L..al.....lt..hYp.c...I+.p.s..sp.............hphhPR.s.h.lFuG..K..AAPuYhhAKpII+.hI.splAchlNsDP.tlsshLK.V.......VFl.NYsVShAch..lI..............PAuDlSEQIShAupEASGTuNMKhhLNGALTlGTlDG...................ANV..................E..hh-....tl.G.....t-N.h.al.F.G..p..s-p.V...t.h....h...t.p..s.................Y....p...s....h....phh.p....ts...tlctslp..l...s.G..h.h...s.s........p........t..h....aptl.h.pp........h......t.....D.ahlhtDatsYhcs.p...................cpltt..Y..........p.s.t..........p.tWhphs.lh.....NhAp.G.hFSSDRoItpYspcIWph........................................................................................................................	0	432	793	1068
+3851	PF00124	Photo_RC	photoRC; 	Photosynthetic reaction centre protein	Sonnhammer ELL	anon	Prosite	Family	\N	21.90	21.90	22.10	21.90	20.10	21.20	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.54	0.70	-5.36	55	8728	2009-09-11 05:37:13	2003-04-07 12:59:11	14	5	3408	262	234	6932	2419	232.40	49	91.25	CHANGED	lYlGahGlhol..hhuhluhhlIuhshhsss........sassh..hpphahlulpPPsspYGLu.hsPLtE.............GGhW.hsshahssulluWhlRpachu+pLGhGhHlshAFuuAIhhalsLslIRPlhMGSWucuhPaGIhsHLDWssshuhpYsNhaYNPFHMLuIuFlaGouLhhAhHGuhILussphs.sscplc..hs.t.usE+ts........hFaR.hh....GashstcuIHRauhahAlhsshhuulGIllo..................Gsll.....csWhpWhshashsPha	............................................................................................ss...htphh.hul.ssusuhGhp.hhPlWEsts.s...cWh..GG.apllshHhhlGlhsahsRpaELuh+LGMRPaIslAaSAPl..AAhsuVFL.lYPlGQG.SaS-uhPhGIuupFsFhlsFQucH.NlhhpPFHMLGVAGVFGGuLh.uAMHGSLVpSoL.....h......h.E......s.s-.......st........otshuachuQEEETYsh......VsApsaFucLIh......suFN..NoRuLHFFhhhaPVsGlWho.....ul.Glssh..................u..h.....tsa.ph..h.......s..................................................	0	46	140	195
+3852	PF01895	PhoU	DUF65; 	PhoU domain	Enright A, Ouzounis C, Bateman A, Cerutti L, Dlakic M	anon	Enright A	Domain	This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [1]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.15	0.72	-3.54	388	11541	2012-10-02 11:27:25	2003-04-07 12:59:11	14	27	3795	24	2708	7226	2003	87.20	22	51.69	CHANGED	ltchuphst.phlppuhpu.h...hpp.D.....phA.ppl.h..pt....-cplDph........tppl..........p.....phhphh.tt..pp..sh.....................hp....h..h.....hht..lspslERluD.aussIAchs	..................................................pMuphst.ph....lp.pul.pu..h.........hpp...D....h........chA..pcl..h...pp..........Dcp.lsph.......pppl.............pc....phhphh..sp.......ppshtp...................lph...h...hs...hlp...hspslERlGD.autsIuch.h.....................	0	935	1793	2290
+3853	PF00502	Phycobilisome		Phycobilisome protein	Finn RD	anon	Pfam-B_10 (release 1.0)	Domain	\N	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.93	0.71	-4.47	22	4056	2012-10-01 21:46:00	2003-04-07 12:59:11	14	6	1323	188	272	2702	388	96.30	32	84.97	CHANGED	TpllssADspG+ahosu-LpulpuhlppustRLcusptlssNtssIlppAuptlascpPplhssGGssYssRph..AtClRDhcaYLRhlTYulluGssusL--hslsGl+EsYpuLGlPsushsculphhKss..shphlu......................upsssEhssYFDYslsulu	...............................................................................................................................................................hh...............................h....thths.......................................................................t.....................................................	0	37	167	246
+3854	PF02333	Phytase		Phytase	Mian N, Bateman A	anon	Pfam-B_14843 (release 5.2)	Domain	Phytase is a secreted enzyme which hydrolyses phytate to release inorganic phosphate. This family appears to represent a novel enzyme that shows phytase activity [1] and has been shown to have a six- bladed propeller folding architecture [2].	18.90	18.90	19.30	18.90	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.35	0.70	-5.75	2	586	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	259	7	131	592	319	193.30	42	71.03	CHANGED	MphsKThLLosAAGLhLohsAsSspA.Hhls-.aHFpVsAtsET-PVsousDAADDPAIWlc.KpPppSKLITTNKKSGLsVYsL-GK.LHSYchGKLNNVDlRYDFPLNGcKlDIAAASNRSEGKNTIElYAIDGcpGpLpSITDPN+PIuosIsEVYGFSLYHSQKTGtaYAhVTGKpGEFEQYElssstpGYloGKKVRtFKhNSQTEGhsADDEYGsLYIAEEDEAIWKFsAEPsGGSpGpVlDRAsGcHLTsDIEGLTIYYAssGKGYLhASSQGNsSYAhYERQGpN+YVAsFpITDG.chDGTSDTDGIDVLGFGLGPcYPaGlFVAQDGENIDpGQtsNQNFKhVsWEpIAp+lG.hPplpKQVsPRKhpDRS	.....................................................................................................................................s.DA.....A...DDPA....lWlpPp......sP......s...p...Sh...lluTsK....c....u......G..Lh..VY..DLsG+...l..Q.....................h..........s...s..........G...+.h...N....NV..DlR....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..................................................................................	1	46	81	114
+3855	PF04833	COBRA	phytochel_synth; Phytochel_synth;	COBRA-like protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_4078 (release 7.6)	Family	Family of plant proteins are designated COBRA-like (COBL) proteins.  The 12 Arabidopsis members of the family are all GPI-liked [1]. Some members of this family are annotated as phytochelatin synthase, but these annotations are incorrect [3].	19.00	19.00	19.10	21.20	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.41	0.71	-4.49	22	265	2009-09-11 09:29:15	2003-04-07 12:59:11	10	3	41	0	152	243	23	163.40	49	35.02	CHANGED	YlAhVTlpNap.ht+lps..WpLuWpWt+cEhIaoMpGApso..-puDC.....upah..hshs+...sCc+cPslVDL.PupshspQluN...CC+sGsl.shu.DPupStSuFQhpVuph.....sssppslpsPpNFplpu.....sPsYsCGsshhVsPT......pF.sssG.ppsTpAl........hTWpVsCshoQ	..................YlAhVTh.NaQ.aR.+Ip.s.PGWpLGWsWAK+E.lIWSMhGAQsT..EQGDC...........S+FK........ushPH....sC++sPs.lVDLLPGsPaNpQ...l.uN...CCKuGVlssa...sQDP.u......susSuFQloVGhu......G.T..oN.c.TV+hPpNFTLtu....PGPGYTCGssthVs.sT......pFhosDt..+RpTQAl......................hTWs.VTCTYSQ..........................	0	22	94	125
+3856	PF00360	PHY	phytochrome; Phytochrome;	Phytochrome region	Finn RD, Mistry J, Hughes J	anon	Prosite	Family	Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to Pfam:PF01590 [1], which is generally located immediately N-terminal to this domain.  Compared with Pfam:PF01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilise the photoactivated far-red-absorbing state (Pfr) [1]. The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue [1].	20.30	18.00	21.00	19.50	19.90	17.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.12	0.71	-5.15	80	3555	2012-10-02 14:34:25	2003-04-07 12:59:11	15	76	2538	22	318	3683	22	152.50	56	28.28	CHANGED	lhchps...hLs-hlh+..chshulhs..psPslhDLlcs-GAALhapsphhplGtTPscpplc-lspWLp.p..t.sss......shu.TDuLscs.YP.sAtslu-sssGhhAlpIo.ppch...lhWFRscssppVpWGGs.ccssphss...st+hpPRsSFcsahElV+s+SlPWcshEh-.....AhcsLphhLhsshh.cp.....ps	..........................................................................................................................IL+TQTlLCDMLLR.....DuP.l.u.IlT...QSPNlMDLV.KCDGAALaYc.sc......h........WhL.Gl..TP..o...E.sQI.+DIsp.WLhch......HssoT.............GLSTD...SL...h-A..GYP....uA..s..s..L.G...Du...........V.C.G...MAAs..pI..o....s......+...D..h........LFW.FRSHTApEl+WGGAK.Hc.P.t..-cDc............up+..M...H.PRoSFcAFlElV+.+ShPWp.........................................................................	0	89	180	254
+3857	PF03284	PHZA_PHZB		Phenazine biosynthesis protein A/B	Mifsud W	anon	Pfam-B_4020 (release 6.5)	Domain	\N	20.50	20.50	20.80	20.60	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.95	0.71	-5.15	8	88	2012-10-03 02:27:23	2003-04-07 12:59:11	8	2	31	21	8	134	0	153.10	69	98.67	CHANGED	Mscstssp.sFsDphEL..Rp+NRtTVEpYMcT+Gp-RLRRHcLFTEDGsGGLWTTDoGpPlVhpG+-+LAcHAhWSL+CFPDWEWaNV+lFET-DPNHFWVECDG+GKILFPGYPEGYYENHFlHSFEL-sG+IKRNREFMNPhQQLRALGIPVPpIKR-GIPo	..................................................................................M.spth.p.shpDt.EL..RR+NRAT.V.E+YMp.hKGt.-RL.pR.H.pLFVEDGCuG...WTT.-oGpPlVhRG+-pL.tc.hA.W....+C.....FPD.W..E.W.aNl+IFET-DPNHF.WVECDG+GKhLhPGYPEG.YhE..NHalHSFEL.Es.G+IKRNREFMNshQpLRALuIsVPpIKR-GIPT...........	0	4	5	7
+3858	PF00388	PI-PLC-X		Phosphatidylinositol-specific phospholipase C, X domain	Finn RD	anon	Prosite	Family	This associates with Pfam:PF00387 to form a single structural unit.	22.10	22.10	22.20	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.82	0.71	-4.80	140	2890	2012-10-01 22:17:21	2003-04-07 12:59:11	14	118	764	50	1401	2585	81	145.10	30	19.62	CHANGED	MspPLo+YFIsSSHNTYLsG.............................sQlt.....up.SSscsYhpsLppGCRClElDsW.......DGsss...p............................................................................................................P........llhH...GtThT...op..l.Fc-VlcsI+caAFhsS.p...........YPlIlSLEsHC.oscpQ..pphAchhpplhG-hLhspshst................ssstlPSPppL+tKILlKsKp	......................................................................................................s.Plo+YaIso..o...HN..oYLh.s.............................pQ.h.h.......u.p...opsp..sY......hps..L.....pt.GsRslE......l...D.s.a.........cus..cs....p..............................................................................................................................................s......hlhH........Gh...s...hs...................sp.l.....hp...-................Vl.c.s.Ipc...a.u...F..tss..p.....................hPl..Il..S.l...Es......+s.....s.p..pQ...p.t...h.....s..p...........hh...pp..l......aG-...h...Lhspshp............................ssptlPospp...L+tKIllps+.....................................................................	0	360	614	1002
+3859	PF00387	PI-PLC-Y		Phosphatidylinositol-specific phospholipase C, Y domain	Finn RD	anon	Prosite	Family	This associates with Pfam:PF00388 to form a single structural unit.	20.20	20.20	20.30	21.00	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.76	0.71	-4.11	86	1860	2012-10-01 22:17:21	2003-04-07 12:59:11	14	98	351	26	1049	1720	51	113.40	41	11.94	CHANGED	-LScLlsYspulp....FcsFpt.sppp....hhchtShsEspspphhc.pp..stp..hlcaN++pLoRlYPpG...hRl.cSSNa.sP..hWssGsQh..............VALNaQT.Dh.sMpLNpuhFp.N.......GpsGYVLKPshhR	...................................................................LSsLl.Yspss.p......ap.s....hp........pt.p..........t..................hhchsShsEsputchh........p..pp...............stc..al..p..aN..p+pLoRlYPpG...hR.l.DS...S.Na...sP..hWssGsQh..................VALNaQT.......sh..sMpLNpuhFp...N.......G..ps..G...YVLKPphh........................	0	250	418	726
+3860	PF02192	PI3K_p85B		PI3-kinase family, p85-binding domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	21.00	21.00	21.10	23.30	19.70	20.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.34	0.72	-4.56	13	271	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	91	6	146	207	0	76.20	47	7.94	CHANGED	hlplcVsppsTlppIKp.LWKpAcphPLaphLt-.suYhFsslNppApcE.ELpDEo..RRLCDlRPFhPlL+LlpRpssp	...........hlslcssRpAoLpsIKp..LW+cAcphPLap..hLp...-.suYlFssVsQ..p.AEpE..EhpDEo....RRLCDl+s.F..hPlL+llp+pGs.......	0	32	44	93
+3861	PF00794	PI3K_rbd		PI3-kinase family, ras-binding domain	SMART	anon	Alignment kindly provided by SMART	Family	Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly  significant similarity) to Ras-binding Pfam:PF00788 domains  (unpublished observation).	20.80	20.80	20.80	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.17	0.72	-4.10	12	588	2012-10-03 10:59:06	2003-04-07 12:59:11	13	31	130	78	323	502	1	105.50	25	9.04	CHANGED	ssp.hPcsl..hh.ssplhlslhhp..........ttp.shThpsssssostplhtphlpK...phshhpps-ssp........DalL+VsGppEalh.ssasLtpapaIppplppstpscLsLhp.st	..............................................s.....t.l...h...p..s.p.lhlslhhp..............s.ppshThpssssss.stplltpslpc.......ppsh...ht.ps.-.tt.............-YlL+VsGpcEYLh.s......c......as.Lspa.............p..a...IppClp.sp......cLhLhp...s...............	0	83	113	201
+3862	PF00613	PI3Ka		Phosphoinositide 3-kinase family, accessory domain (PIK domain)	Ponting C, Schultz J, Bork P	anon	SMART	Family	PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested [2] to be involved in substrate presentation.	29.00	29.00	29.00	29.20	28.80	28.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.20	0.71	-5.11	16	1353	2012-10-11 20:00:59	2003-04-07 12:59:11	15	53	314	96	849	1260	21	179.80	26	14.57	CHANGED	cchcs.sppc+cplcpIlshDPhspLotcE+phlWpaR.a.hlhshscALs.......KhLh.SVcWsshppsspshpLhtc...Ws...lcsscALELLsssass....hVRsaAVpsLEp.hsD-ELppYLLQLVQsL+YE.........................................................hpcShLs+FLlp+ALpNh.clGpFhaWaL+uEh......aspsh.spRFsslhEtahcsh.spthtpltp	..........................................................................................h.............l....l.h.t.h....s.........l.p....p-.pphlW.p.hR....h....hh.....p..............p.uLs...........................+hLh..s.s.p....a..pp..........p....p..s.t...p....h.............h.p.l.L..t..p......................W..s.........l.ss.p..A.LpL.Ls..s..p..ass.....h.............VRpa...AVppL.c.p..hs.c-c...LhhYL.QLVQ.A..L.K...aE............................................................................................................................................h.p.u.....sLscFLl....p.R.............Ahp.s...plu+hlaWh.L.....p...s-h.................cst..ph...t..p.h..t.lhpthhp...........hh....................................................	0	284	422	654
+3863	PF02226	Pico_P1A		Picornavirus coat protein (VP4)	Bateman A	anon	Pfam-B_345 (release 5.2)	Family	VP1, VP2, VP3 and VP4 for the basic unit that forms the icosahedral coat of picornaviruses. Five symmetry-related N termini of coat protein VP4 form a ten-stranded, antiparallel beta barrel around the base of the icosahedral fivefold axis [1].	20.80	20.80	21.60	21.00	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.30	0.72	-4.24	31	6859	2009-01-15 18:05:59	2003-04-07 12:59:11	11	25	444	79	0	4094	0	67.40	60	13.37	CHANGED	GAQVSTQ+oGuHETustAssGSoIsYTNINYYKDuuSsSAs+QDFoQDPuKFTcPVhDlhpcshPsLp	........GAQVSpQpsGoHEss..Ns.AosGSsIsYhNINYYKDuASuuAu+QDFSQDPSKFT-PVKDl.hpchhPsLp.........	0	0	0	0
+3864	PF00947	Pico_P2A		Picornavirus core protein 2A	Finn RD, Bateman A	anon	Pfam-B_138 (release 3.0)	Domain	This protein is a protease, involved in cleavage of the polyprotein.	21.00	15.00	21.20	15.10	20.70	14.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.54	0.71	-4.33	9	2140	2012-10-02 13:45:52	2003-04-07 12:59:11	14	29	270	3	0	2018	0	113.10	63	8.57	CHANGED	NhHLAT.pDapNslh.sasRDLLVsposApGsDpIARCsCsoGVYYCcS+pKaYPVshpsPshhhlcts-YYPtRaQophLluhGhuEPGDCGGILRCpHGVIGIlTAGGpGlVuFADlRDLhhlE-	....................................NRHLATpsDWpNsVWEsasRDLLVooT...sApGsDT.I.ARCs...CpoGVYY.CpS+pKaYPVSFpt....Psh..h....l.ptSEYYPtRYQSHlhlutGauEPGDCGGILR.CpHGVlGIlosGGpGlVuFuD..lRDLhhh--..........	1	0	0	0
+3865	PF01552	Pico_P2B		Picornavirus 2B protein	Bateman A	anon	Pfam-B_214 (release 4.0)	Family	Poliovirus infection leads to drastic alterations in membrane permeability late during infection. Proteins 2B and 2BC enhance membrane permeability [1,2].	20.00	20.00	20.20	21.70	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.26	0.72	-3.84	22	1455	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	271	0	0	1484	0	99.00	57	5.36	CHANGED	QG.loDYlppLGsAFGsGFTspIucplsplpshh..psslscKllKtllKllSALVIllRNpsDhhTVhATLALLGCsGSPW+aLKpKlCphhtl.Palp+Qu	..................QG.loDYIcpL....GsAFGo....G....FTs....pIs-pVs....t..Lpshl...........psslsEKlLKsLlKIISALVIllRN.ppD..h.s..T.lhATL.ALl.GCs...uSPWpWLKpKssphLtI.Phsp+Qu.......	0	0	0	0
+3866	PF00345	PapD_N	pili_assembly; Pili_assembly_N;	Pili and flagellar-assembly chaperone, PapD N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	C2 domain-like beta-sandwich fold. This domain is the n-terminal part of the PapD chaperone protein for pilus and flagellar assembly.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.55	0.71	-4.33	154	7954	2012-10-03 16:25:20	2003-04-07 12:59:11	15	5	993	92	559	3765	45	119.70	30	51.71	CHANGED	ulslssTRlIass..spc.psolplp.Nsss.tPhLlQsWl......-s.........tt......t.ptps.P......Fllo.PPlhRlcssppptlRl...hp..sss....LPpD...R.ESlFalNlppIPsts......................ps...plplAl+s+lKLFaR.P...suLt	..............................ulslssTRlIas.u..s.p.+...ps.slplp.Npss..psh.....Ll.QoWl..................-s......................tss.ppps.s............Fl.lo.PPlh.+lp.stpppplRl..hp....ssp.....LP.pD.R...ES.lFahNlcpIPsts..............p..p........spNsLplA..h..po+lKLFaR.Ptsl.......................................................	0	63	176	377
+3867	PF02753	PapD_C	pili_assembly_C; Pili_assembly_C;	Pili assembly chaperone PapD, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Ig-like beta-sandwich fold. This domain is the C-terminal part of the pilus and flagellar-assembly chaperone protein PapD.	22.80	22.80	22.80	22.80	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.14	0.72	-4.14	155	6654	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	783	91	357	2906	15	65.10	26	28.05	CHANGED	lplpNPTPYalohssl.pls...........spplpss......MlsPhushphslssssss......plpaphINDaG.........uhsptpt	......lplpNPTPYYlols....s.l..pss..............sts.l.pss.......MlsPhust.shslssssss..............plpaphI..NDYG.........uhh....h........................	0	28	98	239
+3868	PF00114	Pilin	pilin; 	Pilin (bacterial filament)	Sonnhammer ELL	anon	Prosite	Domain	Proteins with only the short N-terminal methylation site are not separated from the noise.\	    The Prosite pattern detects those better.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.84	0.72	-3.34	147	1425	2012-10-03 10:38:27	2003-04-07 12:59:11	14	15	722	48	226	1319	90	110.70	23	71.92	CHANGED	ARuQloculuhhsuhKosl.Ehhhsp........Gphssssss.............hGhss.sss..ht.......shsssstsss.....................usIssshssssst......lsGpslslsts..ss..............................ssWsCss.......................sl.sscahP..s.uCp	.............................+uphspslt.hsu.hKsslt-hhhsp................Gth..ssssss..................hGhss...sss.hps.............Vpslsls..s........................GslTsshpssss........lpup.plsLtsp...ts...........................ssss.pW..t..Csss............................sl.ss...chh...PssCp....................................	0	58	120	168
+3869	PF05137	PilN		Fimbrial assembly protein (PilN)	Bateman A	anon	COG3166	Family	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.43	0.72	-4.15	214	1587	2012-10-02 17:03:51	2003-04-07 12:59:11	8	5	1422	0	398	1103	323	79.40	23	35.54	CHANGED	pllspL.sphlP.-s.lalsslp..hpss.......................plplsGhut......s.splushhcsLc.p........................................Sshhp..sspltshppss....................tttp.......htp............Fslpspl	........................hlppL.sp.hlP..-t..saLo..slp....h.pss................................................................................slplpGhup.........o.sslsshhps.Lc..p..........................................sshap.......ssphtshppps......................tps..............hhp............Fplpht.h.....................................................	0	129	253	341
+3870	PF04350	PilO		Pilus assembly protein, PilO	Mifsud W	anon	COG3167	Family	PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.	21.80	21.80	21.80	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.82	0.71	-4.31	75	807	2012-10-02 17:03:51	2003-04-07 12:59:11	8	8	747	2	266	706	143	144.00	26	68.03	CHANGED	L...cptpscEppL+ppappKtppAsNLsta+pQhtpl-ppastlL+QLPscsElsuLLsDIspsGhssGLpFpphc.ts.Els..+-FYsElPIsIpVsGsYH-lGsFsuslAsLPRIV..oLcshslsss....pss..........tLshshhA+TYRah-	........................................................thptpEtpL+pph.pp..K..t...t...ps....s....sL..p....th.......c.....p.......Qlt...p..h...c......pph.......s....t.hl....c.......pLP....s.c.s....E.hssLLpcl..spsuhs......sGL...p.......h.pp......l......p.......t...............s.........p.h.s...............p.c......a............a..h.c.l.P.....l..slp..ls.G.sYaplup...F.sss.l..u...s.LsRIl..olcslslpts....spp.................ttLphphhApTYph......................................	0	94	174	231
+3871	PF04351	PilP		Pilus assembly protein, PilP	Mifsud W	anon	COG3168	Family	The PilP family are periplasmic proteins involved in the biogenesis of type IV pili [1].	21.20	21.20	21.20	21.30	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.54	0.71	-4.30	54	679	2009-09-11 22:48:09	2003-04-07 12:59:11	8	3	667	8	183	533	67	140.50	27	79.17	CHANGED	DLcpahscs+scspspIcPLPchpsapshsYsuss.hRsPF........sPhclt.......t.ttpspsslpPD.....hsRtK...EhLEsasL-sLpMVGol...s.pssthaALlcsssGslaRV+sGsYlGpNaG+lspIo-splplhElVsD.Gp.GsWlERsssLtLp	.....................................................Lptahtphctpst..l.tsh..........h.shsYps.tt..h+..sPF....................s....phh.................thttsssht.P-..........p.Rtc...psL..EpasL-sL+hlGsl..........s.p.s..sphhALl.p....ss...sup.lapVpsGsYlGpNtG+lspIs..c....splplhEhl..D.u.t.GsWhcR.spLtL.....................	1	48	110	154
+3872	PF04697	Pinin_SDK_N	pinin_SDK_N; 	pinin/SDK conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4141 (release 7.5)	Family	SDK2/3 is localised in nuclear speckles where as pinin is known to localise at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque [1,2]. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing [4]. pinin has also been implicated as a tumour suppressor.  The conserved region is found at the N-terminus of the member proteins [3].	25.50	25.50	26.40	26.30	25.20	25.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.61	0.71	-4.13	2	80	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	51	0	41	78	0	126.30	73	20.63	CHANGED	MAVAVRoLQ-QLEKAKEuLKsVDENIRKLTGRDPs-lRPhQsRhLslsGPGGGRGRG..LLRRGhSDSGGGPPAK.RDl-GAl.RLuG-pRsRR-SRp-SDsE.DDDVKKPALQSSVVATSKERTRRDLIQDQs	.......MAVAVRoLQEQLEKAKESLKNVDENIRKLTGRD..P..NDl.RPhQ....ARlLu..L..oGP.G..GGRG..RGu..l.LL.RRGFSDSG.G...G..PPAK.QR..D.LE.G...AlS...RLGGERRTRRESRQESDsE.DDDV..K........K.PALQSSVVATSK.ER.T.RRDLIQDQN...................................................	1	10	12	22
+3873	PF00224	PK		Pyruvate kinase, barrel domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel.  The active site is found in a cleft between the two domains.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.06	0.70	-5.83	13	7047	2012-10-10 15:06:27	2003-04-07 12:59:11	16	29	4703	229	1953	5106	2651	326.30	42	68.66	CHANGED	hR+TpIlsTIGPu.................opoVE....pLpcLhcAGhNVsRhNFSHGoaEYHtssIcNVRcutcphut.......VAIALDTKGPEIRTGshps.....tlplssGcchhlosDtsh.tsssscchlalDYps...lscslpsGshIhlDDGlloLpVlphsssp.plhscspNsGslus+KGVNLPGscVDLPALoEKD+s.DL+FGVcp.s.VDhlFASFlRpAsDVpplRclLG-cG.+pIpIIuKIENppGV...sN...hDEILcsoDGlMVARGDLGlEIPA.cVhlsQKhlIuKCNhsGKPVIsATQMLESMhpNPRPTRAElSDVANAVLDGsDCVMLSGETApGpYPsEuVphMpclslpAEpulsphsla	...............................................................................++TKIVsTl.G....P.A.....................o.p.s.....-..hl.ppll.pA.G.h.NVhRhNFS.H..G..s.a......--Ht.pphppl......R.p.s.tp.p..h..u..cp...................lu..ILh..Dh.................p........G.........P.....c.....I...R..su......p..........h.....c............s.........G....t......................lpLpt.G.pp..h..h...l.......s........s..........c.............t......s..h......t........................................p..c.............p..l.u.l..s...Y..p.s.................l.s.p....Dl.......p......s.....G..s.....hl......L........l.........D.....D........G....hl...p..........Lp.....Vh...p..l....p..........s.................s...........p.......................l..................h.s....c...V..h.....s....u...G........L........u........s.p......K...Gl.......N.......l........P...Gs.....s..l..s.....l..PA..L.oEKD..pp.D.l.p..a..u..h..ct........s...lD.alAhSFlRpupDlt....p....l....R....c.....l.........l........c....p...............p..........G......p.........p..........l.........p.........l.l....uK....IEptE...ul...cN....hD-I..l.....c.....s.....o.....D......G.....lMVAR...GD....L....G....VEl..P......h....E...c.......V.shl................Q.........Kt...l...Ic+s.p..................p.h.sKsVITATQ..ML-S.......Ml...psPpPTR..AEsoDVAN.A....llD.G.TDAVMLS.uEo..AsGpYPlEuVpsMu.pI.s..hpsEp........t.....................................................................	0	656	1238	1641
+3874	PF02887	PK_C		Pyruvate kinase, alpha/beta domain	Finn RD, Griffiths-Jones SR, Bateman A	anon	Prosite	Domain	As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.	21.70	21.70	21.70	21.90	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.29	0.71	-4.54	173	6414	2009-01-15 18:05:59	2003-04-07 12:59:11	11	22	4576	233	1792	4498	1547	116.60	30	23.66	CHANGED	s-...ulutuAspsApc....ls.spuIlshTpSGpTAphlu+hRPs.hP...IlulT.ptp................st+pls.lhhGVhs.......................h...hhsptp.s.........s-chlppu.lch...............uhcpGh.lpsGD..hlllsuG...hstsG..sTNhh+lhp	..................................................................-uluh.uuspsApc......Ls...sp..uIlshTp.S.GpTA+..hl.S.+..aRPs....sP......IlAlT.scp...........................................st+p..ls..Lh..hGVhP.......................h.....hhc.phs..s...........................s-ph.hpt...u...hph...............shc.p.Gh..h......pp...G.D....hl.l.lsuG......s...h.....u....tsG......sTNhh+lh.h.............................................	0	593	1132	1494
+3875	PF02827	PKI		cAMP-dependent protein kinase inhibitor	Bateman A	anon	Bateman A	Family	Members of this family are extremely potent competitive inhibitors of camp-dependent protein kinase activity. These proteins interact with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	25.00	25.00	30.50	30.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.62	0.72	-3.86	9	148	2009-09-11 05:02:57	2003-04-07 12:59:11	11	1	62	106	88	142	0	68.20	41	81.75	CHANGED	TDVEoshuDFhuSuRTGRRNAlPDI.s.SsAssso.u-LslKLutLsl.Ks-Gcpcspcssp-psscspsEu.p.c	........h-VEo..shu-FluouRTGRRNAlPDItu.SpAssso..s-Lsh+LusL.s.lpps-u..ptc...sppsspct.tpspspt....t....................	0	14	19	43
+3876	PF02173	pKID		pKID domain	Bateman A	anon	Pfam-B_1547 (Release 4.2)	Family	CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB [1].	25.00	25.00	26.10	26.70	24.40	22.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.19	0.72	-4.72	17	369	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	106	1	112	349	0	42.00	56	14.79	CHANGED	-s.uDuspssp++.R-ILoRRPSYRKILNDL....uupsssh.....ptpp	.........s-ultDSpKR.REILSRRPSYR........KILN-L....SS-ssuls....+h-............	0	20	30	61
+3877	PF03832	WSK	PkinA_anch; 	WSK motif	Griffiths-Jones SR, Bateman A	anon	Griffiths-Jones SR	Motif	This short motif is names after three conserved residues found in a WXSXK motif in protein kinase A anchoring proteins.	25.00	25.00	25.50	25.50	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.16	0.72	-4.60	12	161	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	35	0	78	190	0	31.00	42	5.82	CHANGED	pcshssWsShK+LVTsRK+s+ssscpcttps	...tcshssWsSFK+hVTsRK+s+sstcpcpt-.t....	0	4	9	23
+3878	PF00069	Pkinase	pkinase; 	Protein kinase domain	Sonnhammer ELL	anon	Unknown	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.65	0.70	-5.24	54	114309	2012-10-02 22:05:25	2003-04-07 12:59:11	20	4512	7677	2311	65911	134432	5368	237.60	20	40.43	CHANGED	aphhptlGpGuaGsV..apuhcpsssp........hhAlKhlptp.ptppptt.t.h....................Elplhppl.p....Hss..I..lphhshhps..................psplh..llhEahsss.....cLh.phlp................tpshl...scppspphhtpllpulpYlHs.p..........sllHRDLKspNILls.psspl...................KlsDFGlAp...................ttsss.thpshsGT.hYhAP....El....lt...............sptasttsDlWSlGlllhphls.....Gp......sPFt.sp........sphthhtphhtsthphs...............................................ppspcllpphLphcPpcRho.....sppllp+sah	..............................................................................................................................................................................p.l.G...p....G...s.h....u..................V................h...h.......s......h......................t.....t...t........................................h...A.....l...K......h.....h....p.................t........t............................t...........t................................................................................E..h...p...h.....h....t...p....l......p..............................H.............p..........l...........l......p.....h....h...s....h...h...t.p......................................................................tp.p..h..h.........l...l...h...E.......h........h..t...s.t...........................................s.L..h....p....h..lp.................................................................tt..t.....h...............s....t....p.....h.......h...............t......h.......h....h........p.............l...............h............p............u.......l........p....a.......l.......H...p...p.....................................................s.l.....l......H............R..............D.........l..............K..............P.........p................N...........l.....L.....l........s.....p....p...s..p.h....................................................................................+.l...s.......D.....F....G.....h...up...........................................................ttt..t.......h....p......s.....h......h........G......T....................h...........Y..............h..........u......P..............Eh..........h................................................................................t..t....t....h.....s..........t....s.......D.....l.........a...............u..............h..............G............h.....l....h........h.....p...h..h.t.......................u.p............................................s...a....st..................................................p......................h.......h..........t.......h..........h.....t..............................................................................................................................................................................................................................................t..h....p....h..h..........t.......h.....h.....t..............p.....s...t...p.....R.....s..................t...h...........................................................................................................................................................................................................................................	0	23780	38306	53856
+3879	PF00433	Pkinase_C	pkinase_C; 	Protein kinase C terminal domain	Finn RD	anon	Pfam-B_135 (release 1.0)	Family	\N	20.90	15.00	20.90	15.70	20.80	14.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.80	0.72	-3.44	160	3537	2009-01-15 18:05:59	2003-04-07 12:59:11	19	82	369	79	2010	3207	9	48.00	30	6.79	CHANGED	plputpDssNF.D.........p...cFT.pps.....................................................sthoss......s.thh..............................sshsp.......pp..FhGFoYsssp	.........lpu.pDssNFD...........p....-FT..pps.................................................................................................................................................sthoPs................ttpsl.....................................ss.sp.................pp.......FtGFoYss............................	0	477	765	1344
+3880	PF02253	PLA1		Phospholipase A1	Bateman A, Mian N	anon	Pfam-B_3500 (release 5.2)	Domain	Phospholipase A1 is a bacterial outer membrane bound acyl hydrolase with a broad substrate specificity EC:3.1.1.32. It has been proposed  that Ser164 is the active site for Swiss:P00631 [1].	19.70	19.70	19.80	22.80	18.30	19.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.91	0.70	-4.96	78	1227	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	1131	11	196	747	50	244.60	43	80.00	CHANGED	.uhlspchph-ptsp...pssaslpsa+sNYlLPhoas.sssNppshpst..........s.t..hcshEsKFQlShKhsl.hpslhs.t....sssLahuYTQpSaWQlYNp.p.SuPFRETNYcPElFhhhsss.....h...h.....hphphlslG...hsHpSNG+ussh..SRSWNRlYsshsacp.....s.sa..slsh+sWaRIsE...stpp.......D.DNPDIpcYhGph-lshsYths.cpphshhlRpNhp..sss+GulclsaoaPl........tspl+hYsQYFsGYGESLIDYNpcp.p+lGlGlsLs	.................................................htsh.......t..hppp..cssaslhsYcsNYll.as.o.sshNppshss.t...........sps.....t++sEsKFQLSlthsL....ac..s.l.lG........susLhhuYTQpSaWQl.Ns.cp..SSPFR..E...TNYEPplFlsassc.....aphs...hhshR.p..l..phG...hsHpSNG+.......o-Pp................SRSW.N...RlYsphhh-p.......G.sa..hlpl+sWahlsp....s........D.DNPDIs+YMGYaplpl..uYphs..-thl....o.h..phpaNh.........ssuaGusEluhoY.P.I.............spcl+hY..sQhasGYGESLIDYNapp.oRlGlGlhLs.................	1	39	107	161
+3881	PF01735	PLA2_B		Lysophospholipase catalytic domain	Bashton M, Bateman A	anon	Pfam-B_2127 (release 4.1)	Family	This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain Pfam:PF00168.  Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all  phospholipids extractable form yeast cells [1].  Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids [2], the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic  domain of the protein as discussed in [2].	19.70	19.70	19.70	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.57	0.70	-6.33	15	966	2012-10-02 11:19:24	2003-04-07 12:59:11	13	15	204	2	571	979	5	338.50	26	56.67	CHANGED	IulAsSGGGaRAMLsGAGhluAhDsRs.ssss...sLGGLLQSoTYluGLSGGsWLVGoLAhNNasSlpslhsp..tp.slWslspSlhs.P..tGlsls.pshphasslscpVppK+sAGFNlSLTDlWGRALSashhs.hppGGsuhTaSSlpssshFQsuEhPaPIhlADGRh....PGsslIslNuTlFEFoPaEhGSWDsolpuFssscYLGTplsNGsPl.pspClsGaDNsGFlMGTSSoLFNphLLp.lNoos.....hsshlppllpchLp.-hSpcps.DIu.Ys.sNPFp-ss.h.tpstos.........sIssscsLaLVDGGEDG..QNIPLhPLLpspRcVDVIFAlDsSs.Dscp.WPD.GsSLVsTYERpau....spu.puhuFPYVPDspTFlN.LGLss+PTFFGCDu+NhTsh....sp.sPPLVVYlPNs.aoahSNlSTFKhsYs-o-RpuhIpN.GFcuATpsN.p.DssFhuCVuCAIlpRp.EphNhotPspCppCFpsYCWNGTls	............................................................lulhhSGGGhRAhhshhG.hlhuhp........................sGlLpssoYluGlSGu.sW.h....h....u....olh.s..s.........h...s.....p..sl................p.............................................h.t......h..p..ps...........hhp................................h.............p.......p..h..tha................h.p....pltt..+tpt...G..h....hohsDhW..................G.h.h.l.........s..p.hh.....................................................t............t...................s.........h.........phS...s...p..................p.t.h.p...pup.PhPIhsu......th.p.............................s.s..............................h......t.h....t........p.........hhE.FoPaEhG...........ph...tuF.hshchhGoph....Gp...................................t............................p.....thh..........h..............Ghhhus.....u...h....s.......thh..................................................................t..h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..........................................................................................................................................	0	144	261	426
+3882	PF02988	PLA2_inh		Phospholipase A2 inhibitor	Griffiths-Jones SR	anon	Pfam-B_1254 (release 6.4)	Family	\N	21.70	21.70	21.80	21.80	21.00	21.40	hmmbuild  --amino -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.98	0.72	-3.55	5	85	2012-10-03 01:43:02	2003-04-07 12:59:11	10	2	45	0	26	94	0	82.30	38	41.96	CHANGED	+SCEICHNlG+DCsu.asEECuSPEDsCGTVLhEVSSAPLSlRolHKNCFSSSlCKL-aFDlNsGpEoYLRGRIsCC-c-cCEs	...............sCElC+s.hG.psCsG.hh..cpCsuscDsCsplh.hEloo.uslShpssaKsChoSshC+LshlssNhGpcsYlRu+hpCCpp-sCcs........	0	2	2	12
+3883	PF00321	Thionin	plant_thionins; 	Plant thionin	Finn RD	anon	Prosite	Domain	\N	20.50	20.50	22.80	23.80	19.50	16.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.19	0.72	-3.74	37	120	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	29	31	30	148	0	44.90	51	37.08	CHANGED	KSCCPoTsARNsYNsCRlsGs.spshCAshoGCKllSussCPssas.+	..KSCC.oTsuRNsYNsCRhsGs.upthCAslssCKllSG.sCPssas+....	0	4	5	14
+3884	PF01307	Plant_vir_prot		Plant viral movement protein	Finn RD, Bateman A	anon	Pfam-B_881 (release 3.0)	Family	This family includes several known plant viral movement proteins (e.g. Swiss:Q85292) from a number of different ssRNA plant virus families including potexviruses, hordeiviruses and carlaviruses. 	20.30	20.30	20.50	23.90	19.40	20.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.54	0.72	-4.31	78	326	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	133	0	0	321	0	104.10	33	92.51	CHANGED	LoPPPDao+shlssulGlululhlahls+..s.sLPpVGDN..lHsLPHGGpY+DGTKplpY.suPspt...........ttpssphhshhhllhLs.hhIah.sph..........ptptC.spCs	..LoPPPDhocshhshAlGluluhhl.ahhsp..s.pLPps.GDN..lHpLPHGGpYpDGTKpIpY.ssPppt.............tp.ss.ph.t.shhllllLs..hhIhhhspht.........ppppC..pC.h...................	1	0	0	0
+3885	PF04819	DUF716	Plant_viral_rep; 	Family of unknown function (DUF716) 	Finn RD	anon	Pfam-B_5106 (release 7.6)	Family	This family is equally distributed in both metazoa and plants. Annotation associated with Swiss:Q9SLW7 suggest that it may be  involved in response to viral attack in plants.  However, no clear function has been assigned to this family.	25.00	25.00	28.30	27.20	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.89	0.71	-4.74	32	388	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	80	0	247	370	0	128.40	27	44.55	CHANGED	hshuL...ppLhhuhAFh.EhhLFahHs.p........s+tulEsphH.LLlhslhlsshsshltlhhPpshh..lpLh+ushlhlQGsWFh.........................QhGFhLasP............................sstschc...tspccshhhlshpFsWalshshlhlsshYsh	................................................................h...slpplhhuhAhhhp.....hhLFhhHs..p........s..+tsl.-h.p.hH.LLlhslhlsslsshlclh...h..P..s.......s.hh............l..pl.h+uhhhllQGoWhh.........................QhGFhLasP................................hstsphc...psptpshhhlshtFsW....HlhhshlhhhshYs.h........	0	44	107	147
+3886	PF05015	Plasmid_killer		Plasmid maintenance system killer protein	Bateman A	anon	COG3549	Family	Several plasmids with proteic killer gene systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of those systems result in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.00	0.72	-3.84	8	1079	2012-10-03 00:18:00	2003-04-07 12:59:11	8	3	735	0	333	1012	133	89.40	31	94.60	CHANGED	MhhsF+cKsLcpFapcss..optIsushsc+Lpc+Lphl-sAps.pDLphP...uh+hc+L+G.chcsaaSI+VNspaRLIFpacsu.s.....ssllsYlD.H	...........................................MlhsFpc...ct.hppha...p....t.tp.....tpt....h......s..p.h..tpth.t.++LphLcsAp.s...h...pDLphPs.....u.+LctL.pG......c..c..p......G.aSI+l...Ns...p...aRlsFc.apss..s................sh.lph.DYH..............................	1	107	224	290
+3887	PF01672	Plasmid_parti		Putative plasmid partition protein	Bashton M, Bateman A	anon	Pfam-B_1163 (release 4.1)	Family	This family consists of conserved hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete, some of which are putative plasmid partition proteins [1].	22.10	22.10	22.10	22.10	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.68	0.72	-3.55	34	451	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	32	0	18	262	0	83.30	42	46.53	CHANGED	AYtYLKlApulp-GllppchlhEsGhppohphlcsccssshKKS+p..........N.IKPLRFQLKspESYDFYKpNuKFTuFlL-clFpspKD	........sYpYLKIApulp-Gllp.chlhcNGlppolphlcspp.s.pl+..KS+p..........N.IKPLRFQLKspES.YDFYKpNsKFTuFlL-clFpspK-........	0	17	17	17
+3888	PF05016	Plasmid_stabil		Plasmid stabilisation system protein	Bateman A	anon	COG3668 and [2]	Family	Members of this family are involved in plasmid stabilisation. The exact molecular function of this protein is not known. This family also encompasses RelE/ParE described in [2].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-10.17	0.72	-3.59	158	6528	2012-10-03 00:18:00	2003-04-07 12:59:11	9	12	2562	20	1504	5217	580	85.40	16	88.52	CHANGED	lthstpA..tpDlcclhchh............spphhpplppthpplt.ptsthscs.................h.thhphtht................sahlhYp..l......p.tthll.llplh+ppcth	...............................................h.hstpA..hc-lcclhphh...................tpph...h.pp.l...t..p.t.l.p.p.Lt....p.s.t.hspt.........t.........................h..sh.hc.h.t.ht................sahl.lYp.l..........ppsp.tl..l.l.lplhcppp.........................................	0	448	979	1251
+3889	PF00681	Plectin	Plectin_repeat;	Plectin repeat	Bateman A	anon	Pfam-B_68 (release 2.1)	Repeat	This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.	20.50	20.50	20.50	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.78	0.72	-4.43	119	3591	2009-01-15 18:05:59	2003-04-07 12:59:11	15	114	75	10	1456	3428	0	43.40	31	9.87	CHANGED	hpLL-uQhuoG.GllD.Ptssp+lolcpAhccGllstchtppLhpsp	.....................lLEuQhsoG.Gll.....D.Pt.....ss.....c.....+.lo.l.ppAhp+GllstchtptLhps...........	2	150	264	648
+3890	PF01523	PmbA_TldD		Putative modulator of DNA gyrase	Bashton M, Bateman A	anon	Pfam-B_845 (release 4.0)	Family	tldD and pmbA were found to suppress mutations in letD and inhibitor of DNA gyrase. Therefore it has been hypothesised that the TldD and PmbA proteins modulate the activity of DNA gyrase [1]. It has also been suggested that PmbA may be involved in secretion [2].	19.70	19.70	20.90	20.80	19.40	17.40	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.71	0.70	-5.14	158	5034	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	2139	8	1513	4013	3929	291.30	25	63.32	CHANGED	sts-l....hhp...p.spshsl.phpssclcphpp.spstuhulRl......hh....ss.+hG.husos...shsp.ps......lp.phlcpAh..p....hAc.......hspt......thtthsshsthsht...............hp.t..........htsh...shcc.......thchht.chpptstphttthhs.......sshspsppphhlhsSpGhphppppshhththpshsp......pssphpps.............ht.h...................tthsscpl.....ucpu....scpAhptl..s..upphpsGph.s..Vllsspssusllp.shs....pshpucplhps..pShh.....ts.......+l....GcplusptlolhDDPp...h.....suhuohsaDsEGlss.pcphll-cG.lLpsa	.................................................................................................................................u-l.hhpp.spstol...sh...c....pu..plcssph.....st-..pul.Gl.Rs.........................ht.............sp..+pG...hA....t......os.........slo....tu....................lt.pslpt..Ah..s.....................hA+....hsst................ttsshsshs.hshp....................hp.........h.sh..t..shcc.................tlclht.cs-ps.u.hs.t.-tclpps.......tuuhssthphhlhuso..c......Ghhs...s.php...shhplussllup.........csschcps...h..........shtshphh.....................t....sscth..................uccA........sc.p...A..lspL...s......utts.s...s..G.ph..s....Vlhusshs.....us.Llpcslu..p..ulpG.stsh+t.........sShh......ts..............pl.....Gc.p.l.s....s....p...h....lT..lh-Dsp..............l...........pthu.S..hsh............DsEG.s.ss..ppp..slIcsGlLpsa.....................................	0	444	903	1233
+3892	PF03332	PMM		Eukaryotic phosphomannomutase	Mifsud W	anon	Pfam-B_3713 (release 6.5)	Family	This enzyme EC:5.4.2.8 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.	20.00	20.00	20.20	20.10	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.37	0.70	-4.79	9	691	2012-10-03 04:19:28	2003-04-07 12:59:11	8	10	520	12	309	572	314	202.50	39	83.41	CHANGED	hc-hLp.cLRp+lsIGlVGGSDhpKhtEQLs...tcsVlscFDYsFuENGLsuY+tG+.lupQolhpaLGE-KlpcLlNFsL+Ylu-lDlPhKRGTFIEFRNGMlNlSPIGRsCSpEERp-FtcaDKp+pIRpKhVcsL+ccFs..chGLTFSIGGQISFDVFPpGWDKTYCLpHlEp-..FcsIHFFGDKTh.GGNDaEIasDPRTIGHoVsuP-DTlphlpElht.	......................................................................................................phlt..cLc.p..+.sslulVGGSDhs.KhpEQl...........tp......s..l..h...........p..p.a...D.....ahF..sENGhhhY+.sc.hh..p..ps.h....hphLG-.-.p.hp.c.h.l.p.asLph.h...u..c..l...p...l......P..h.....+.......R..G.sFl.E.hRs...GhlNlSPlGR.ssoh-ERpt......ap.p.h.D.KcpplRpphltsLppcFs.................ths..Lpash..GGpIShDVFPpGWDK..sY.s...Lpc...l.............p...p...p..........t.......h..p.pIaFFGD+s.....G..GNDYEIasp..p.s.hGasVssPcDThphhcpLh.....................................................................	0	99	159	241
+3893	PF03901	Glyco_transf_22	PMP; 	Alg9-like mannosyltransferase family	Finn RD, Bateman A	anon	DOMO:DM04662 & Pfam-B_7750 (Release 8.0)	Family	Members of this family are mannosyltransferase enzymes [1-2].  At least some members are localised in endoplasmic reticulum and involved in GPI anchor biosynthesis [3-4].	20.40	20.40	20.70	20.60	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.61	0.70	-5.48	16	1285	2012-10-03 03:08:05	2003-04-07 12:59:11	12	33	352	0	898	1337	89	359.40	19	69.81	CHANGED	hhahhhlshRlhsuhhsth...csDEhapshEsh.HhhlashGh.TWEap.phulRSaha......hlhthshhhlthhhtcsphhl............................................hhhsRlhhulhusls-hhlaphlspph......................................shpluphhlhh.lsshhhhhsuochhssShphhhshluLthh................................................hshhhlsshuhhtRPpusllhlPlshh.............hL..hhpphhpta........hhhslshhshhhh...slllDphaY...............G+hlhsshNhlpaNVh....sstsshYGscPaaaYhhsshsthshshhhhhlhushhh...................................hhsshhhhLhlaShhsHKE.RFlaPlh.Plhhlsuuhslsph.....................phthpth........hhhhhlhhhsslshuhhhulh+phGsh..h....chhstlppss.......t.s....slh...................lhtphaphPsphal.	......................................................................................................................h....hhh.hph.h...shhs..h.....psDE.....ap..-...sh....t........h....h.................h.........h........h....................s........h.................s..W.-a..........................s.l....Rshha...............................h...h..h...h...h...........h...h.....h....h.........h.h.....h........................h..h.....................................................................hhhsRh.h.h.uh...h.s.h.h.s....h....hhhp....h.t..ph.h....................................................s.....p..h..s...hh....h..h...hh.....hh..sh.....h.hhh...htoc...h...hss.shthh..hsh.huh.hh..h.....................................................................................................................................................t...hh.hh....h..h....shhu..h.h...h..t..s.....hh.hhh...sh.h.h...................................h.l.........hh.t..p......h.........................hh.h...s..h...h..h...h...hh........h...s.lhlDsh.a.a............................................................t...p.h..s..h......s....hs..hlhaNlh.......tstssha.G.......s..p.......Phh.aYh..hpsh........h.h.h....s..h...h..h..h..h.h..h..hhhh..........h.........................................................................................h..h..h.h..h.hs.hhh.h..l....hl..h.Sh..sH....K.E.RFlhP....hh.P..hl...h...l.h.u....uh....sh.t.h.h..............................................................................................................................hhhhh.h..h.hh..shhh...u.h.hhuh.h....p..ths.......................h........h......t.....................................................................................................................................................................................................................................................	0	296	484	741
+3894	PF00822	PMP22_Claudin	PMP22; 	PMP-22/EMP/MP20/Claudin family	Bateman A	anon	Pfam-B_1393 (release 2.1)	Family	\N	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.09	0.71	-4.59	13	2113	2012-10-03 00:20:40	2003-04-07 12:59:11	15	8	110	0	1175	2148	0	165.70	24	76.65	CHANGED	MhlhLhuhhlsplusssLLhloTl.sshWhlushss..................htsGLW+sCsssosssphssts.....t.pssLpAspAhMlLSl....IhulluhllhhhQhhshcpGscahl........uGIhhllusLClllusuIYTs+hssthtpsh......scacaGauahLuWluFshshluGllY	..................................................................................................................................h....hhuh.h.lshhuhl..sh.lh..s..ssh..s...h..Wh..hs.shh.s....................................................................hhapGL...WhsC...sh........p................u.......................s...............s.........t..h.....p.....C.......p........h...s...........s............h......h........s..........h.........s............s.............l....Q.........u.........s..R..u...L.....h..l....h..ul..............................llu..h..lu..h..l....l....s....h.....h......G....h....p.....C......h....p....t...s....p..p.ttsht..............................................hhhhuGl..h.a.l.l.......u..........G.lhs..l......l.ul...s..h......a.....s.......s......p........h........h..p..-......h...h....s..sh...................t.chch.........G.....huh.alGWsushlhhlu.Gsh....................................................................	0	109	224	589
+3895	PF01625	PMSR		Peptide methionine sulfoxide reductase	Bateman A	anon	Pfam-B_1111 (release 4.1)	Family	This enzyme repairs damaged proteins.  Methionine sulfoxide in proteins is reduced to methionine.	22.30	22.30	22.30	22.30	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.86	0.71	-4.35	66	6530	2009-01-15 18:05:59	2003-04-07 12:59:11	16	26	4318	25	1573	4711	3705	153.90	41	66.75	CHANGED	ppshhAGGCFWssEshFpplt........GVlpspsGYsGG..psps.PoYcpVsps......oGHsEsVclpaDPshloappLLchF..aph.aDPTphstQusDhGsQYRSuIahpsppQcphAcphhpphppp............hsptlsTplpsh..psFasA...E-YHQcYht+pspt..Ys..phhh	.......................pshhAGGCFWuhEphF.p.p.l.s.........G..Vh...sstuGYsGG......ps......t.N......Po.....Y...c.pV.ss....sp............TGH......sEsVclsa....DPph...l..........S..a..cpLLp.ha..a.ch...h..D..PT.......s...h..s....p..QG.s..Dh.G.sQYRo.uIah...p......s.....p.....c......Qcp.....hAcpshp..p.hppp.....................hpps.I..sT.E..l..............t......s.....h........p..s.......F.......Y....A.......E-YHQpYh..c..KNPpt..Yst..hh...............................................	0	508	1007	1340
+3896	PF02366	PMT		Dolichyl-phosphate-mannose-protein mannosyltransferase  	Bashton M, Bateman A	anon	Pfam-B_556 (release 5.2)	Family	This is a family of Dolichyl-phosphate-mannose-protein mannosyltransferase proteins EC:2.4.1.109.  These proteins are responsible for O-linked glycosylation of proteins, they catalyse the reaction:- Dolichyl phosphate D-mannose + protein <=> dolichyl phosphate + O-D-mannosyl-protein.\	  Also in this family is Swiss:Q94891 Drosophila rotated abdomen protein which is a putative mannosyltransferase [2]. This family appears to be distantly related to Pfam:PF02516 (A Bateman pers. obs.).	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.35	0.70	-5.01	22	2315	2012-10-03 03:08:05	2003-04-07 12:59:11	13	20	1595	0	896	3419	711	228.90	21	38.08	CHANGED	hhhtlhuhhsRhaplshsspllasEsphschtshYhptpaahss+..PPluphlluhshh.....lsshsssa.a.s.h.phhss.sshhthRhhsuhhusLsssLsYhhshphshsthsuhluullhhh-suhlT.u+ahLl-uhLlFFhshuhhshhph...............hotphhhhhhlsGluLGhulssK.hsuhhslhhlhhhshhplWphh......cpph.hh........................h.ahhsphhhLlllPhslalhh..ahlHhhhhh	............................................................................................h...hhhshhhhhhhh....h..s.....sh.....h..........sc.................h..........t.....Y....h......c....h..s.....h.............h..........hp..........s.hs...........hh..h.......s..hh...............h.h.t...h...s..........s.....s...h.......h.....a....h...ps....h....s......p......h...h...h.....s............h.........s....................h...u......h.R.h..h.......ss..hh....usl.s.ls.l.s......hh....hs..h.c.............l.....h.............t........s......p............h........s.........u.hl..A.u.l.lhh...h......p.....s...h.h.....h.....s.h.u..p.h..s..l..L...D...s...h...l..s...h....a.l...s..s.u.h.h..s..hhhhh.................................ptt..h....t......t....s....h........h.......h....h..h.....h..l....h..Gl.s..h.Ghu..h..hs.K...h...h....s..h...h....s..l............l.h...h..h..h....h....h.....s...h....h..p.t.h..h..................p.th.h...h.h....................................................h...h..h....h..h....h..h..h..L..l.l..l..P.h.h.l.hlh...h..th..h.............................................................................................................	1	277	520	754
+3897	PF03393	Pneumo_matrix		Pneumovirus matrix protein	Mifsud W	anon	Pfam-B_3641 (release 6.6)	Family	\N	20.80	20.80	21.90	51.30	20.00	16.30	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.47	0.70	-5.45	9	182	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	17	2	0	128	0	183.10	74	99.13	CHANGED	METYVNKLHEGSsYTAAVQYNVlEKDDDPASLTIWVPMFQSShPADlLIKELtslNILV+QISTPcGPSL+VhINSRSAVLAQMPsKFoISANVSLDERSKLAYDlTTPCEIKACSLTCLKsKsMLTTVKDLTMKThNPTH-IIALCEFENIhTSK+VlIPTYLRSISVKsKDLsoLENIsTTEFKNAITNAKIIPYAGLlLVITVTDNKGAFKYIKPQSQFIVDLGAYLEKESIYYVTTNWKHTATRFuIK	..........................................FQsshs.s.lhc.LhslTITTLYsASQsGPILKVNASAQGAAMSsLPKKFEVNATVALDEYSKL-FDKLTVCEVKoVYLTTMKPYGMVSKFVsSAKuVGKKTHDLIALCDFhDLEKshPVTIPAal+SlSl+pp-.solEshhosEhcpAlTpA+IhPYuGLlhlhThsssKGhFKhltstsQhIV-LGsYlptESl........................	0	0	0	0
+3898	PF03246	Pneumo_ncap		Pneumovirus nucleocapsid protein	Batreman A	anon	Pfam-B_3020 (release 6.5)	Family	\N	18.70	18.70	22.90	22.90	18.40	17.40	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.12	0.70	-5.94	4	663	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	24	70	0	329	0	129.50	46	99.85	CHANGED	MSLppl+LsDlp.KculLspSpYTIpRssGsoTulospslQpclspLCGMlLhTcascac.sApIGhQYhhotLGp-co.pILRsuG.cVpsVhT..Ksaol.hpGKphKhE...VLsIpulssuhhtslEhpARcohsphLKEtu.plPpNQR.sAPDsslIlLCIuALlhTKLAusscsGL-sslRRAspVLpsthpRYPph-l.cIAcSFYELFE+KsYYhslFIcaGhA.uSopuGS+sEuLFsslFMpAYGAGQsMLRWGVlA+SspNIMLGHsSVQAEhcQVsEVY-hspKhGsEuGhhHlRpsPKAuLLSLTsCPNFuSVVLGNAAGLGIIG.Y+Gps.NpELFsAAcuYAcpLKEsNhINaSuLsLTsEE+EAhpp.LNhsDDsspc	.....................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+3899	PF03438	Pneumo_NS1		Pneumovirus NS1 protein	Bateman A	anon	Pfam-B_3221 (release 6.6)	Family	This non-structural protein is one of two found in pneumoviruses. The protein is about 140 amino acids in length. The NS1 protein appears to be important for efficient replication but not essential [1]. The NS1 protein has been shown by yeast two-hybrid to interact with the viral P protein [2]. This protein is also known as the 1C protein. It has also been shown that NS1 can potently inhibit transcription and RNA replication [3].	20.50	20.50	21.70	266.10	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.85	0.71	-4.36	2	37	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	12	0	0	30	1	136.00	85	98.24	CHANGED	MGSpoLShIpVRLpNlaDNDcVALLKITCaTs+LIhLTpsLAKuVIHTIKLsGIVFlHlITSSDhCPsssIlspuNFToMPlLQNGGYIWEhMELTHC.QsNGLlDDNCEIpFSK+LSDSphspY.NQLSpLLGhs	MGsNSLSMIKVRLQNLFDNDEVALLKITCYTDKLIhLTNALAKAVIHTIKLNGIVFlHVITSS-lCPsNNIVVKSNFTTMPlLQNGGYIWEhhELTHCSQsNGLIDDNCEIKFSK+LSDSsMTsYMNQlS-LLGhD	0	0	0	0
+3900	PF02478	Pneumo_phosprot		Pneumovirus phosphoprotein	Mian N, Bateman A	anon	Pfam-B_2290 (release 5.4)	Family	This family represents the phosphoprotein of Paramyxoviridae,  a putative RNA polymerase alpha subunit that may function in template binding.	21.00	21.00	21.50	23.70	16.70	20.90	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.74	0.70	-4.87	8	859	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	20	0	0	264	2	99.10	76	96.37	CHANGED	PEGKDILFMGsEAAKhAEAFQ+Sl+psuptt.pSIsG-.lpT........luEplpLPslspss............osKsuppKssptsssslh...-lEplpEchlssss-sps.sscss-ossps.....KK+VoFcsscs...G+YTKLEKEALELLSD.pEDsD-ESSlLTFEE+Ds..ousSIEARLEuIEEKLSMILGhL+TLslATAGPTAARDGIRDAMlGlREELIscIhsEA.....KsKAAEhh+EE-sQRuKIGsGS.VKLTEKA+ELNKIlEDpSoSGESEpEpE....-sDtpt-DI	.........................................................................................................................................................................................................................................lREELIA-IIKEA.....KGKAAEMMEEEMNQRSKIGNGS.VKLTEKAKELNKIVEDESTSGESEEEEE.K-hQ-NNQt-DI.......	0	0	0	0
+3901	PF01048	PNP_UDP_1		Phosphorylase superfamily	Finn RD, Bateman A	anon	Pfam-B_1190 (release 3.0)	Domain	Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.13	0.70	-11.60	0.70	-5.39	159	15802	2012-10-01 20:25:13	2003-04-07 12:59:11	15	225	4828	837	4138	10648	3603	227.10	18	76.95	CHANGED	plullsuss............tchtthtpp.........h.ph.hhp..............tthphhhGph......tsttlslstpG.........h.Ghspss..hsshthlp..th.......................tsctllthGss........Gul....p.s..lp......sGDlllssp.....h.......lp.........hshtss....hh...................................................hhsshsth..hssplhphhtp..........htphs........................hplpp....Gshhsssuhhhps................tschp...hhpphG.......ss.....sl.-MEssshstlApph.s..ls.....hh.slpsl....os.............ttt..................pphtphhppstpphtpl..ltphlp	...................................................................................................................................................................................................hsllsu.s.............cht.hhp................htph...hs...................tshhhh.h.Gph............pup.p...l........s..l...h...t..sG.................h..G..hs.s.s....s........hhs.ttllp......th..........................................................ss..c...tl..l..t..s..Gs...s......................Gul...........pts....lp....................lGD....l..l..l..sps.........h.....................hp....................hssss.......h.h......................................................................................................................hh.st..hts....s....s....p...l.h..p...thhp................................sspphs.............................................................hphch.......Gshhos-shhhss............................................tphp..............hhpp.hu.....................sh.........sl..-ME.uusl.......s.t.s...u.tp....h...s.....l...........hh..slts.l......oDhh.t.............................................................ph.t...........................................................................................................................................................	0	1276	2469	3410
+3902	PF02233	PNTB		NAD(P) transhydrogenase beta subunit	Bateman A, Mian N	anon	Pfam-B_2220 (release 5.2)	Family	This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes.  The domain is often found in conjunction with Pfam:PF01262. Pyridine  nucleotide transhydrogenase catalyses the reduction of NAD+ to NADPH. A complete loss of activity occurs upon  mutation of Gly314 in  E. coli [1].	19.80	19.80	19.80	20.20	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.59	0.70	-5.71	10	2429	2012-10-03 09:55:27	2003-04-07 12:59:11	11	22	2140	27	707	1732	3888	439.00	53	87.05	CHANGED	sLhphsYls...uulhFIhuLtGLSspcTARtGNhhGIlGMsIAllATl..lssstsshs..................hlluulllGusIGlhIAp+VpMTsMPQLVAhFHSFVGLAAVLVuhAsaltppstuhsssu.............s.sshphlElaLGlaIGulTFTGSlVAFGKLQGlIsS+PLhLPu..RHhLNhuLLlssVllhlsFhhssshssthssLll..................uluhlhGhpLVhuIGGADMPVVISMLNSYSGWAsAAuGFhLsNsLLIlsGALlGSSGAILSYIMCKAMNRSlhsVIhGGFGsssusuuucs.t...sGps+psoA-EsA-hLhsApSVIIlPGYGMAVAQAQaslA-lschLcccGlpVRFuIHPVAGRMPGHMNVLLAEAsVPYDlVhEM-EIN-DFscTDVVLVIGANDTVNPAAp-DPsSPIAGMPVL-VWKA+sVlVhKRSMuoGYAGV-NPLFa+-NTpMLFGDAKKss-pllcpl	................................................slsshsYllAulL...FI...huLtG...LS...p.cTuRpGNhaGhh..GMul.AllAT...l....h..s..s..s...s...t..s..hs..............................h.l.ll.uhll...GGsl....G........hhh..A....++Vc..MTpMPpLVAhhHShVGLAAVLVuh.su...alp....t..s..h...s..h.h.............................................h.ss..hphsElaLGl..h.IGAlTFTGSllAFGKLpG.......p.....l.........s...u.....pP..l.......hL.Ps....+..H.hl...Nlsh....ll..s..sh.h.h..h..l.hF.s.........t..s....s...u........h...........h..h.s..L.hl.hs...........................hlAhshGhtllhsIGGADM...........P......VVlSMLNSYSGWAAAAtGFhLs..NslLIlsGA............LVGSSGAILSYIMC.....K.......AMNRSFlu.....VIh..G.G......F.G.....s...........s..s........s.....s......s................u...s...s...t...........................ttGp......h..+.p...ho.......A.......-..........-.s...............A.thL.....p.sApoVIIsPGYGMAVAQ..AQasVtElscpL+t.c.Glp.V..+FuIHPVAGRhPGH.MNV....LLAEAcVPYD...hVhEMDEIN...cD.FusTDVVLVIGAND.sVNPA.Ap-.DP.sSPI.uGMPV....L-VaKAp....sVlVhKRSM.s.oGY....................AGVpNPLFa.c.-N.Tp.....ML.FGDAKpsl-sllcu................................	0	215	421	584
+3903	PF03833	PolC_DP2		DNA polymerase II large subunit DP2	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	24.00	24.00	24.00	40.70	23.00	23.80	hmmbuild  -o /dev/null HMM SEED	900	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.62	0.70	-13.57	0.70	-6.88	6	125	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	111	1	80	138	362	805.40	45	69.80	CHANGED	ccYFEpLpcEl-+hY-IAcpARc+GhDPossVEIPlApDMA-RVEuLlG.pGlAcRIRELs.t-huRE.sALclucEIl-G+FGDhc...+Ecth-pAVRTALAILTEGlVAAPlEGIAcV+Ic+N..sDsocYLAlYYAGPIRSAGGTAQALSVLVuDYVR+tlGlDRYKPoE-EIERYlEEV-LYcptss.LQYpPos-ElRLsscNhPlpIsGEuT-csEVSGHRDLsRVETNplRGGhhLVLsEGll.KAPKllKYscplslEGW-WLcclhcusccu-...........t...pEEc.tlst...............ssDKalcDlIAGRPVFuHPS+sGGFRLRYGRuRNoGhAThGlpPATMaLls-FlAlGTQlKsERPGKAusVVPVDTIEGPsVKL+NGDVl+IsshpcAhcVRs-VtEIL.LG-hLlsYGDFLENNHsLhPAuascEWWIQpl.sus..........................tsDsctl+.........ts.s-pAl+huc-aclPLHPcYTYaWHDlosE-lchLtshltp..p.chpspc.....pchVL.lch.ppsKclLEhLGlsH+V+-splll-paaPhhtuLGhslppp.....phph.hpstpssl-hlNtluslcl+c+A.ohIGuRMGRPEKAc-RKM+PsVHsLFPIGpAGGupRsItcAsccsp.......shcVEluht+CPsCGcpohpphCPsCGoh.c............................sclcshs+pcIcLs-lhccAhcslGlpc..hDclKGVKGMhStpKhPEPLEKGILRAKp-VaVFKDGTsRFDsTDlPlTHF+PpEIGVSVEKLRELGYs+DhhGsELcc--QlVEL+PQDVIlscsuA-YLl+VAsFlDDLLp+FYsL-tFYNlKscEDLlGHLVIGLAPHTSAGVVGRIIGFocAssGYAHPYFHAAKRRN	.........................cYFcpLppclcchaclAccARppGhDPpscVEIPlApDhA-RVEsll........G................cG..VAcRIRE.Lt..pchu..+..E.....sALcluc-h.....s.....-GchGchs......+cpth-tAlRTAlAlLTE.GlVAAPlEGIucVcltcN..sDGo-YlslYYAGPIRSAGGTAQALSVLVuDYlRptlGlsca+P..p..-...-ElERYsEElpLYcptss.LQYpPps-El+hhscNhPlplsGEsT-c.EVSGaRDLpRV-........TNplRGGhhLVlsEGlhhKAsKlh+....as....c....p....lth-.uWs.WLp-llssptpsc.............................................t..c.....p......p.t..t..................................htsssKalc-lIAGRPVFuaPSc.GGFRLRYGRuRNoGaAosGlpPAoMhllD-FlAsGTQlKsERPGKAssVsPVDoIEGPhV+LpsGsVl+l-s......hccAhc...............l..+......spV-cIL.lG-hLlsaG-FlENNHsLhPuuYs.EWWhp-htpss...................................................hs.p.hp.............ss.ccAlchupchshPLHPcYTYhWcDloh--lttLtchlhp.......hpt.t..............................tp....l...l....p.......t..phKc....hLEhLhl.Hp.....h.....p..s.....pplhl..p..t..hs..hhhsLGhshp................................tht..t..........h...t...ss...psslchlNclushcl+p+AsohIGsRMGRPEKucpRcMpP.sspsLFPIGp.uGGspRsltcAsc.psp....................hpl-luhpcC..spCGp...ohhthCstCGspp...h.C..Ct........t..........................C.psthc.hpshpp......tplslpphhppAhcpls.pp...hc.lKGV+GhhSppKhsEPLEKGlLRAKpslhsFKDGTlRaDhTDlPlTHF+PpE.lslolE+L+ELGYpcDh.GpPLpp--QllEL+sQDllls................c.....s....sucYhl+supFlDDLL-+aYulp.FYsscpp-DLlGcLVhGhAPHTSAGllGRlIGFopAtVGYAHPYFHAAKRRN........................................	0	17	48	68
+3904	PF01620	Pollen_allerg_2		Ribonuclease (pollen allergen)	Bateman A	anon	Pfam-B_1050 (release 4.1)	Family	This family contains grass pollen proteins of group V. Swiss:Q40963 has been shown to possess ribonuclease activity [1].	25.00	25.00	77.70	26.60	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.09	0.71	-3.89	12	100	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	13	15	2	117	0	121.20	46	87.34	CHANGED	TVALFLAVALVA.....GPAASYAADuGYsP..............sssTPAssus....AuGKAT.T-EQKLl................EDlNAuFKAAsAAAAssPPADKaKT..FpssF.osusKu.lAstuo.........psstLssKLDsAYplAYcuApGATPEAKYDAFVuuLTEALRVIAGsLEVHAVKPAs	............................................................................................................................ttE.plI................-clsAuFKsAssAAsusPssDKFps..FEAuF.stu.Kt...........ssuu..uht............shphlPpL-AA.hK.AYsAssuAsPEsKYssF.AuLocAlpshuts.cV..s................	0	0	0	2
+3905	PF01190	Pollen_Ole_e_I		Pollen proteins Ole e I like	Finn RD, Bateman A	anon	Prosite	Family	\N	20.80	20.80	20.90	22.70	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.88	0.72	-4.15	91	693	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	68	0	380	702	0	93.10	23	40.42	CHANGED	VpGhVaCpsCpt..th.....sshsltGApVplpCcs....stt......thhtpuhTDppGhFp...ltl.t.s............tt.ptCpshLhso...Pps..sCshst.............uhpsupl	.......................VpGhVhCssCpt...shp.....tstsltGApVplp...Cpst......pst........hthptp.usTDpsGhFpltlss.s.................tttptCpspLh..so.....sps.......sCst.ts...........h.................................	1	40	199	290
+3906	PF00659	POLO_box		POLO box duplicated region	Bateman A, Mistry J, Sammut SJ	anon	Prosite	Family	\N	21.00	21.00	21.00	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.22	0.72	-4.00	81	913	2009-09-12 20:48:28	2003-04-07 12:59:11	13	8	221	70	585	888	4	67.70	25	17.34	CHANGED	aps+hulsapLSsusltV..FsDpo+lll.ssptp...tlpYls....p................ptppppashsph..........spplpc+lphlc	.........hps+hulsapLossoltV..F.s......DpT+lll..ssstp........tlpYls.......c.........................................ptpp.psathsp..............hsppLtp+lphh..............................................	1	224	294	444
+3907	PF02563	Poly_export		Polysaccharide biosynthesis/export protein	Mian N, Bateman A	anon	COGs & Pfam-B_1505 (Release 7.5)	Family	This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export.	26.80	26.80	26.80	27.00	26.00	26.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.59	0.72	-4.22	183	3850	2009-01-15 18:05:59	2003-04-07 12:59:11	11	25	1898	24	1011	3117	920	91.50	27	23.26	CHANGED	sshsssssss..sYplGsGDhlplpVaspsc..............................................................sht......VsssGpIshPhlGslplsGhTssplppplpppLpp..hl...psP.pVsVpltp	............................sh......ts.pYplusGDhL....pl..s...V...a..s.psp................................L................................................s.s.......shh............VsscGsI.hh...P....h.l.G.p.lplsGhThsp...lpspIps+Lsp...hl......ps.P...pVsVpl..t...................................	0	301	639	825
+3908	PF01743	PolyA_pol		Poly A polymerase head domain	Bateman A	anon	Pfam-B_814 (release 4.2)	Domain	This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.	23.00	23.00	23.80	23.10	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.78	0.71	-3.92	21	6516	2012-10-02 22:47:23	2003-04-07 12:59:11	15	54	4623	24	1693	4940	3053	124.10	35	27.78	CHANGED	hYlVGGsVRDhLLG+ps...c.......DhDlsos.........AssppltphF.tpphhh.....Gtcathhplhhss..ph....lElAThRscp..tshts.pp.phs............ol--DhhRRDFTINAlhhs.....sssp....llDhhs.GhpDLcsphlR	..............................................................................................................hYlVGGuVRDhL...L...Gp.s........+...........................................DhDl.s.s.s..................................................up..P..c.p...h.p...p..h...h......p......psh.......h..................................G......h.......ca...t...sh..tV.h..h...ps...pt......................hEl.sT.hR...s...-p.t.......t..s....s..s..p.....p...s..ps..phsp.................................................................ol-.-Dh......tR......RDFTINAlAhs.......................t.s...s...p.............llD.a...s...G..h..pDLps+llR.................................................................................................	0	581	1098	1445
+3909	PF01518	PolyG_pol		Sigma NS protein	Bateman A	anon	Pfam-B_803 (release 4.0)	Family	This viral protein has a poly(C)-dependent poly(G) polymerase activity [2]. 	25.00	25.00	27.90	27.10	16.50	16.10	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.14	0.70	-5.97	4	145	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	59	0	0	124	0	334.10	58	99.39	CHANGED	MssolRluVSRssuGsuuQTlhpsahLLRssloscshpsshthQ.+FPshtpss+pLsPLtshstDRhl++ssltplhoR-hhhssDh.tphsacssshPho.sspuhphtcLlsshauEt...h-Hl....hPs.usoYsPuulA+hhohsMAGhsP.cG-shhhcssl.aLAA-LlsaphsLPYhls.lDGsosI.shPotsVEchLss.lutLsslDhSaGlEsRuDpRhTpDsupsSSRSlNEL.scEptt+h.shKlhLsh.shQLKlELDsLAcp+sE.pt.thlsuFGp+LFpQhShFusIDp-LhpLslhIKDpshths.tplhphWo.IRou.ucslssuuhslplcsGsWhltcG-DstLoVpPsRl	...........................................tshRhslS+.ttsssuQplh.NaYLLRCNISADG.RNAT+AVQuHFPaLSRAVRCLSPLAAHCADRT...LR..RDNVKQlLTRDLPFsSDL.INY.AHHVNSSSLT..TSpGVEAARLVAQVYGEQh.shDHl....YPoGStTYCPGAlANAISRIMAGFVPpEu-sFs.sGsIDaLAADLlsapFVLPYMls.VDGcsp.I.VlPot.TVEEMLss.suLLN.sIDASFGIES+SDQRMTRDAAEMSSRSLNELc-HEpRGRM.PWKIMLAhhAsQLKlELD...ALADpRsEsQuNAHVTSFGuRLFNQMSuFVsIDRELMcLALlIK-pGFAMNPuQlsuKWo.IRpS.usohshSuhplplctGpWhhhp.....................................................................................	0	0	0	0
+3910	PF00738	Polyhedrin		Polyhedrin	Bateman A	anon	Pfam-B_423 (release 2.1)	Family	These proteins are found in occlusion bodies in various viruses. The polyhedrin protein protects the virus.	25.00	25.00	71.90	71.70	20.60	20.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.34	0.70	-5.29	17	392	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	161	4	0	238	0	188.10	78	98.09	CHANGED	lGRTYVYDNKaYKNLGuVIKNAKRK+HhlEHEhEE+pLDsLD+YhVAEDPFLGPGKNQKLTLFKEIRNVKPDTMKLVVNWSGKEFLRETWTRFMEDSFPIVNDQElMDVFLVlNhRPTRPNRCY+FLAQHALRCDPDYVPHEVIRIVEPSYVGsNNEYRISLAK+GGGCPlMNLHSEYTNSFEpFlsRVIWENFYKPIVYVGTDSAEEEEILLEVSLVFKIKEFAPDAPLaoGPA	.........................................................LGPGKNQKLTLFKEIRsVKPDTMKLVVNWSGKEFLRETWTRFMEDSFPIVNDQ.E.lMDVFLVlNMRPT+PNRCYKFLAQHALRCDPDYVPHEVIRIVEPSYVGsNNEYRISLAKKGGGCPlMNLHSEYTN.SFEpFl.s+VIWENFYKPIVYlGTDSAEEEEILlEVSLlFKl....................	0	0	0	0
+3911	PF03364	Polyketide_cyc		Polyketide cyclase / dehydrase and lipid transport	Mifsud W, Mistry J, Wood V	anon	Pfam-B_1457 (release 6.6)	Family	This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.71	0.71	-4.15	95	3012	2012-10-02 19:24:03	2003-04-07 12:59:11	15	30	2234	27	1131	3986	1993	127.70	23	69.89	CHANGED	lshssp.plaslls.Dh...cpascahPhsp...........s..scllppsst........................................phphshtshpppa...sscsttphspp............................................ht.hpspWphhsht.............................................tstsplphphph..pht..hhshhhthhhpphhpphhpshp	....................................................................lshsscphaplV.s..Dl...ps...Y.PpF..l..Phsp...........................u..s...c..l.lppsss..........thhA.......................................................................pl.p.l.u.h...s..u..l...p.p..s..F.......so.c.s..p..h..p.spp.................................................................................l.h..p.h..h...s...G.....s..F...c...p...h....ps..t..W..pFps..hs.............................................................tsssclphp..l.ca........-..a..s..s..t...l..h...p.h...h..huhhhpchspphlpuF.................................................................................................................................	0	346	687	944
+3912	PF01736	Polyoma_agno		Polyomavirus agnoprotein	Bashton M, Bateman A	anon	Pfam-B_1917 (release 4.1)	Family	This family consist of the DNA binding protein or agnoprotein from various polyomaviruses. This protein is highly basic and can bind single stranded and double stranded DNA [2]. Mutations in the agnoprotein produce smaller viral plaques, hence its function is not essential for growth in tissue  culture cells but something has slowed in the normal replication  cycle [1]. There is also evidence suggesting that the agnogene and agnoprotein act as regulators of structural protein synthesis [1].	20.40	20.40	26.00	26.00	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.87	0.72	-4.33	3	130	2009-09-11 01:00:53	2003-04-07 12:59:11	11	1	5	0	0	117	0	58.10	81	91.17	CHANGED	MVLRQLSRQASVKVuKTWTGTKKRAQRIFIFlLELLL-FCcGEDSVDGK.RK+souLTEps-S	.MVLRQLSRKASVKVSKTWSGTKKRAQRIlIFlLEFLL-FCpGEDSVDGK.Rp+po.uLTppp.S........	1	0	0	0
+3913	PF00718	Polyoma_coat		Polyomavirus coat protein	Bateman A	anon	Pfam-B_748 (release 2.1)	Domain	\N	20.10	20.10	20.20	27.90	18.60	19.90	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.15	0.70	-5.51	12	3425	2009-01-15 18:05:59	2003-04-07 12:59:11	15	1	57	68	0	825	0	141.30	62	81.55	CHANGED	LLlKGGlEVL-V+TGPDShTpIEAaLNPRMGps.........tphaGFSpsIslusshssDsPppspLPsYSsA+ItLPhLNEDhTCsslLMWEAVSlKTEVVGloSLhNlHu.tup+s...sshGuuhPlpGhsaHhFAVGGEPL-LQGlhpNapssY....PssllsPp.....shsspuQV..LsPphKA+LDKDGtYPlEsWsPDPS+NENTRYFGoaTGGhpTPPVLpFTNTsTTVLLDENGVGPLCKGDGLYLSuADIsGhasppss.pQpaRGLPRYFsloLRKRhVKNPYPloSLLsSLFsshhPphpG	......................................................................................................................................................................................................................................................tsPPVLphTNTsTTVLLDE.GVGPLCKuDsLYlSAsDlCGhF.........TspsG.sQpWR....GLsRYFKlpLRKRpVKNPYPIShLLssLhN+hs.+VsG...................	0	0	0	0
+3914	PF00761	Polyoma_coat2		Polyomavirus coat protein	Bateman A	anon	Pfam-B_871 (release 2.1)	Family	\N	25.00	25.00	43.10	25.30	18.70	22.50	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.24	0.70	-4.93	8	383	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	41	1	0	366	0	225.50	48	91.94	CHANGED	GAsLolLhphlApVuElAuuTGhSVttIhuGEAhAsIEl...plAsLs.slE.Gl....sssuEAlAAlGLTspsaAllsut....P....sAl...uGh.......AAlh.QTVoG....uSAl...AssGhpaausWcHcVssVsL.tp.sMALplahP--.hDILFPGspoFsp.laYLDPh.+.WGsSLFpsVGpulW.c.lhRs......shspl..s..o..+-lptRTsp.lp.......-oLARaLEssRWslosuPlshYssl....psYYupLsslsPs.hRQlApR.h..hshG+o...slDpsDuhpthspch..-l..ppPp.sp..............SGpaIEKhtAPGGApQRsAPDWMLPLLLGLYGDlTPshcuacDp.ppcc+c	............................................................................................................................................................................................MALplapP--haDILFPGVssF..VNsl...pYLDPt.H.WGPSLFpoluQuhWp.llp-...........slstl..s..S..pElpcRTpchhh.......-sLARhLEpopWslsN...u...P.hshYshl..............p-YYucLs..sl.pPs.lRQl..Ap.Rctp.lshG+oa..slDpsDslpthspph..cl...cs.p..lp..............SGEaIE+shAPGGANQRsAPpWMLPLlLGLYGsVTPuLcuhE..DGsppKcc.R................................	0	0	0	0
+3915	PF00348	polyprenyl_synt		Polyprenyl synthetase	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	21.10	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.58	0.70	-5.54	16	11487	2009-09-13 10:32:47	2003-04-07 12:59:11	12	34	5158	295	3330	8899	6348	242.40	28	77.16	CHANGED	llttht.hhhtuG.KRlRPhlllhsuchlu.........hphsshhslAsslEhlHshSLlHDDl..MDsuclRRGpPTsHtpaGpssAlLsGDulhspAFphlsphp....h.sphphhtl.cLspsssspG.lt.QhhDlpst........chohcphhphhptKTutL.FtsusphuulhuGss..tctpcsLpcauhplGhAFQlhDDlLDhhusspplGK.sGsDlppsKsThsslhuLct...uppctppllcpshpp..pphshpshsth.tlcthtthhh	.....................................................................h....h..hh.h.h.s.G.G...K.RlRP.hls.l.h...s.s.p.h.hs....................................hp.t..p.t....h.....h.t.hA...s.u..lEh....lHs...hoL....l.............HD.....Dl........hD....ps.c..hR..R.Gp.s.....................T.........s...............p.................t.................t................a..................G...................p..........s................s.............A................l......LsG.D.......hL.....h...s....hA....ap.h....l.s....p.hs.............................p.........p.......h...h...t.....l.....h.....p.....h.......s..............h....s.......s...h..............s...........p.G....ht.....Qhh...c....h..t...s.t..................................................ph.s.h..c...p...h....h.p.l....h...pt....K...T..utL..ht........tu.sph........G.u.........l.....h......u............s......s.................s........t..........p........................h...............p.......t.....l....p....pa...u...pt.l.G..h.AF.QlhD...Dl.L.D.h..........h...u.......s......s..p............p.....h..G...K.s.s.....G.s...Dl.p........ps..K...Th....P..hl..h...u...hcp............up.t....t...t....t...t.....h...h..p...p.....t...........t..........................................................ht.......................................................................	0	1100	2096	2820
+3916	PF01943	Polysacc_synt		Polysaccharide biosynthesis protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family are integral membrane proteins [1]. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon [2]. The family includes SpoVB from Bacillus subtilis Swiss:Q00758, which is involved in spore cortex biosynthesis [3].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.75	0.70	-5.13	31	9954	2012-10-02 21:24:20	2003-04-07 12:59:11	12	25	3559	0	2091	9084	1735	278.40	14	58.36	CHANGED	lh+NhhhhhhsplhshllshlhhshluRhLuspsaGlhuhshshsshhshlsshGlsssls+plutsps.........phtsthhhsshhshhlhsllhhhhhhlht............hhshschshlhhlhhhhhh..hhhsss.hhshlhpuh.-phphhslpphlpplshhhhhhlhlhhhss.....lhhhshhhhhusllshllshhhhph.h..h...........hphhhht.hpth+phlp.uh.lhlsplssslhsthspl.hluhhhGsts........lGhYssuhplhhhh.tlhsshss.shhPhhuclh	.............................................................................................pssh.h.hhh.up.ll.s.h..h.l.u.h.l.h.h.h....h...h..s...p....h....l.......G.....s......p.....s...h.....G.....l...h...sh...s..hs...l...h...s.h...h....h...h...l....s...s.......h...G.....l....s....s....u....l....s....+.h.....l..u..p..hps.............................ph..h.p.....t...h....h......h....s.....h.....h.....h.....h.....h.....h.....h....h...s....l.....l....h.....h...h..h..h..h..lhs............................hht......t....s.....p.....h.....t..........h..........h.....h....h....h....h....s..h..shh.........h.h....s...h....h.......s.....h.........h.....p....s....h...h....p....u........h........p.......p......h.....p....h........h...s....l....p.......p.......l....h...t....p....l....h......t...l....h.....h....h...h....l....h...h..h.h..h.h..t...........................hh..t...h.....s..h..h..h..h..h..u...s...h..l.s...h...l....h......s...h..h..h...h...h...h.hh....t...........................................ph..t.h.............h...t....h....h.....p...p........h..h......p....h.....u....h.........h....h....l......s....s.l....s.h.....l....h....p....hl.-.p.....h....h.........l...s...t...h...h...sh.st..................................hG..ha....s..h...u.h...p.......l.h.t.h.h.h.h.h.h.sshhs..shhPhlst..h.............................................................................................................	0	663	1369	1745
+3917	PF02719	Polysacc_synt_2		Polysaccharide biosynthesis protein	Mian N, Bateman A	anon	Pfam-B_1536 (release 5.5)	Family	This is a family of diverse bacterial polysaccharide biosynthesis  proteins including the CapD protein (Swiss:P39853) [1], WalL protein (Swiss:O86159) mannosyl-transferase (Swiss:O05349) [2] and several putative epimerases (e.g. WbiI Swiss:O69130).	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.51	0.70	-5.52	77	3666	2012-10-10 17:06:42	2003-04-07 12:59:11	10	11	2439	14	813	25131	16928	278.60	42	55.79	CHANGED	lLVTGuGGSIGSEls+Qllph....sPpclllaspsEhshYplcp-...h...h.t.pl.......lGDVpDpcplppshpthpl-hVaHAAAhKHVPlsEh.NPhEul+sNlhGTtNlhcAAlpssVcphVhlSTDKAVpPsNlMGAoKRhuEhlh.Ahsppp......................TpFssVRFGNVLGSpGSVlPLF+cQIppG.GPlTlTcPchTRaFMTIsEAspLVlpAu..shucGG-.....lFVL-MGpsV+IhDLAcphl.cL.Ght..........DIpIchsGlRPGEKLYEELlhps-shpsppasclhtsps	.......................................................................................................................lLlTGuu.GS.I...Gu..El..s......+..p.l..h.ph...........s..P...c.......c.....l....l.......l.......h.......s..........+.........s.......E......h........s.......h....a....p......lp..p-........................l..........h..t...p...............l.....p....h.........................h....I..........u......D.....V...................p.............D.......p......p......p......l......p....p......s.....h.....c......................h.............p............s.....-.........h...........V...a....H....A....A.......A......h........K......H.....V......P........h......h.............E.......h.......N.....P.....h....E....A....l.....+....s........N..........l....h.....G........T....p..N........l.......h.......c...............A..............A.......h.........p...............s..............s................V..............c.................+............h.................V..............h...............l...............S.................T..................D.................K.................A....................V................p.................P................s................N...............l................M............G................A................o................K..R.....h....u.....E...h....l...h...u...h.spps.......tp..............................Tp.a..s..s.V..R......F......G....N.......V.......L.......G.......S.........p.........G..........S.......V........I......P....l....F....c...c...Q...I.......p....p......G.......u...P...l..T....l.......T......c....P.......c.....h.......T...R...a...F..M...T...l...s...E....A..s....p....L...V.......l...p...A.u........s...h...u.........c........u....G..-................l....F....V...h..c..M....G....p..s...l..+...I...h...D...L...Ac...ph.l...p.L..G............................-lp.I.c.h.s.G.l.R..........P.........G.EKLaEELlspp..E..t..hps.pphtchahh...........................................................................................................................................................................................	0	272	542	695
+3918	PF02530	Porin_2		Porin subfamily	Bashton M, Bateman A	anon	Pfam-B_1122 (release 5.4)	Family	This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to Pfam:PF00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.   	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.36	0.70	-5.41	16	586	2012-10-03 17:14:37	2003-04-07 12:59:11	9	3	282	0	170	720	19	326.40	28	88.24	CHANGED	DAlVtAEPEPsEYV+VCDsYGsGaFYIPGTETCl+luGYlRhphshGs.....t...sh.ss.ssstpssastpoRhplphsTto-TEhGsL+sahchhhshssss...su..t........................................hslt.AaIpLGGh+sGpshShaDs.hlGhtuDslss.......spthNplpYpa-uGsuFsAulSl--tpusss................................hs...hsspssslVuuVcsstuhushpsssu.................aDs-hcpsAs+stlslp...susu.olhlsGsYusus..Y.........................................hsssp...................Wus.....huuhpapsssKsslssuhph.......................sshstatlGsslcYshlcslohps-lsYschsp.......................phpsp-slsGh	.....................................................................................................................................................Dh.lh.c..sh-YV+lCshaGsGaaYIPGT-TCl+ltGYlR..h..-s..t.h.ss................................s.h....s.s..p..t.pss..hst..tu..Rh...t.lphsot.opTEhG..s..Lps...ahph...ca.s...hs..sss.t..su............................................tts..htlphAalph...u....G...hphGhs.S.Fps..htu..h...s.s.slss...sh.ss.ssh...ps.s.p..lsYTashG.s.G...aoA.s...lulEpss..ssss.....................................................s.sh......h.ss.h.h.Pcllutlch..stuaG..uhthssA...........................................................a-s.....s.......h..p.t.....aA......s..p.s...tssls......lss.t.slhlpu..sYu..su..s...................................................................................................................................................................................................ssstp......................htt...W..ss.t..Wss............................au.uh.p...att.st+h...t.h.shthsh.....................................ssh..ttht.ss..ssltap.V.shshss-htYhp.hs....................................st.hsh...................................................................................................................................................................	1	38	89	115
+3919	PF01379	Porphobil_deam		Porphobilinogen deaminase, dipyromethane cofactor binding domain	Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	\N	22.10	22.10	22.70	22.70	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.42	0.70	-5.42	19	4004	2009-09-11 15:01:14	2003-04-07 12:59:11	15	21	3728	9	1153	3057	2572	207.30	46	65.99	CHANGED	pl+IGTRpSpLAlhQuphVhctLcphhPs....hph-lhhlpTpGD+ILDpsLuKlG...GKGLFsKELEpALLps.....clDlAVHShKDlPs.lPcGLhlusIscR-DP+DAll....pshpsLppLPpGullGTSSLRRpuQLttphPcLchcs.lRGNVsTRLpKL-ss..-aDAIILAsAGLpR...LGhpsclsp.....h.s-phLPAlGQGALuIEsRpsDpchhslLp	................................h.lpIuTRpS..LALhQuphVtstLp..tt..a..P.s.........................lpsEl.lsh.sT.pG.D...t....I....L....D..s..s.L.........u...+.......l.G............GK.G.LFsKELEpALLcs.......csDlA...VHShK.......D......l......P..s..t..h..P..pG.LsL.u.sls..cR.ED.....PR.DAhV.....o....................p.....s..............h......t..........s....Ls...s........L...P..........p....G..u...........l..........VGTSSLRR....p....s.......QLtt..........h.....R........P..........D..........L.......pl.p....s..l...RGNlsTRLpKL............c........sG...............-aDAIILAsA..GLpR................L.......G.h..p..s.....c....lpph.................lss-.....hL.......P..........AsGQ.GA....luIEsRts.D.pchhtlL.s.......................................................................................................	0	364	739	986
+3920	PF03900	Porphobil_deamC		Porphobilinogen deaminase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	\N	21.30	21.30	21.40	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.62	0.72	-3.87	21	3787	2009-09-11 23:02:33	2003-04-07 12:59:11	10	15	3616	9	1082	2829	1539	74.20	34	23.23	CHANGED	thpshAERuhl+pLpGGCpVPIusauph.....tsp................lpLpuhlsssDGh........hhchptps.....t.pcutclGhclAcclhs	...........h.hpVpAERuhhppL.-GGCplPIuuaAplp......ssp................................................................lp.Lc..u.lVu.s.sDGsp...............hlcsphpG.............................s.pcucplGhplAccLl..................................................	0	334	692	920
+3921	PF00280	potato_inhibit		Potato inhibitor I family	Finn RD	anon	Prosite	Domain	\N	24.50	24.50	25.20	24.50	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.02	0.72	-3.83	60	372	2012-10-01 19:32:51	2003-04-07 12:59:11	13	2	66	54	144	396	2	61.90	42	75.93	CHANGED	KsSWPELVGhsuctA+tlIp+-pPslpsl.ll...sGos.VTtDa..cssRVRlaV...st..tsh.VspsPtlG	...........................KooWP.ELVGhsscpAc.ph.Ihc..-pPclpll..Vl....PsGoh....VThDa..cssRVRlaV.......st........sh..VspsPplG..............	0	20	82	119
+3922	PF00767	Poty_coat		Potyvirus coat protein	Finn RD, Bateman A	anon	Pfam-B_868 (release 2.1)	Family	\N	19.70	19.70	20.20	19.70	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.56	0.70	-5.09	33	6595	2009-01-15 18:05:59	2003-04-07 12:59:11	13	28	378	0	0	5499	0	218.30	55	33.96	CHANGED	+D+DVssGT.sGTFsVPRlKsls.sK.hplP+l+G+slLNL-HLLpYpPsQhDlSNTRATppQFpsWYcuVKp-Y-lsDp.pMsllhNGLMVWCIENGTSPNIs..GsW.....sMMDG-EQVEYPLKPll-pAKPThRQIMsHF.SDsAEAYIEhRNsccsYMPRYGLQRNLsDhSLARYAFDFYElTS+TPsRAREAHhQMKAAAlRssssRhFGLDGNVuTp-EsTERHTAsDVN+NMHoLLGs+h	..............................................+D+DVssGo.sG.phsVPRl..ct..h..opK.MphP..p.h.c.G.pslLN..L-HLlpYpPpQ...h.DluNTRATppQFcsWa-uV+t-Y-l.s.-s...pMsl.lhNG...L..M.V..W.CIENGT.S.P....slN..GsW...............sM..M..D....G...-...-..Q......V..E.Y.P.lKPll-pA..+...PT.....hRQIMtHF....S.DsA.E.A.YI.E.h.R.Nt.pc.sYMPRYGLpRNLpDhSLARYAF..DF...YEhs.S+.TP.sRAR.EAHhQ.MKAA.AL.+..ssps+.LFGLDGsVuopp.EsTERHTspDVspshHsLLGhp.s......................................	0	0	0	0
+3923	PF00157	Pou	pou; 	Pou domain - N-terminal to homeobox domain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.42	0.72	-4.33	20	1357	2012-10-04 14:01:12	2003-04-07 12:59:11	12	9	164	22	578	1331	1	69.20	59	18.40	CHANGED	c-ssshcELEpFA+p...FKp+RIsLGaTQuDVGhALusLaGss...FSQTTICRFEuLQLSaKNMCKL+PlLc+WLp-AE	.................c...ss.cELEpFA+p......FKQRR...IK.LG..aTQuDVGhA..Lu.........sLa.G.ss...FSQTTI...C.R..................FEuL.pLSFKNMCKLKPlLpKWLcEA-......................	0	111	158	327
+3924	PF05061	Pox_A11		Poxvirus A11 Protein	Moxon SJ	anon	Pfam-B_5994 (release 7.7)	Family	Family of conserved Chordopoxvirinae A11 family proteins. Conserved region spans entire protein in the majority of family members.	25.00	25.00	32.10	30.30	24.70	19.30	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.92	0.70	-5.36	9	62	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	43	0	0	49	0	290.10	58	99.77	CHANGED	MTslPVTDIsN...-YslTsFSEDsYPsNKNYEIToGQLSILRTVN-KL.....LA+TppspshpsDlspt........hhPs-DsPhoIlp+V.uPpssa.-sss.......llhuE..pQRppRlNIhhS.stEslIE+cslpp...tloSl.op..............TPSLGsVFD+-KRl+LLE-ElhpL+p+ps...psssNL-NFT+lLFGKsshcSsElNKRlsIVNYASlNpSsLThEDLEsCS-EEID+hYcslKQYN-ohKK+IlVTphIoIlI.VlEQlLVKLGF-ElKGLSsElTSEIIDlpIG-DCEtIAsKlGIuNSPlLNIslFllKhhIpRI+Ih	.........................................................................................MTTVPVTDItN...Dh.lT.pFSEDsYPSNKNYEIThtQhSILppVNshl.....hAhssSPp..phpSpls-s..................lhPD-DSPsTIIE+V.pPpTshlD.sssssp.....tEllluE..QQRppRhNIpVS.stEAlhEpcsh......IT.ShPop..............TPSLGVVa..DKDKR..IphLE-EVhpLRNppu.pocoSsNLDNFT+lLFGKsP.h+SoElNKRIAIVNYAsLNsSsLSlEDL-lCSE-EID+IYKsIKQYpESRK+KIIVTNlIII.lI.sIIEQsLlK.L.GF-ElKGLSo-lTSEIIDVEIG-DC-AlAsKLGIGNSPVLNIlLFllKlFV+RIKIl..........	0	0	0	0
+3925	PF04651	Pox_A12		Poxvirus A12 protein	Mifsud W	anon	Pfam-B_5523 (release 7.5)	Family	\N	25.00	25.00	45.40	38.30	23.20	22.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.44	0.71	-4.17	11	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	41	\N	0	60	0	182.20	63	97.69	CHANGED	MA-.KKLo.R..SSYDDYIETlNKlTPQL+TlLuHIuuEQusptsNhs....sssssss.pssuG...sssohp+op+soposspp......+.ss............SGAPpR+pss..hus.sc..psQ..hhQAVTNuGKIVYGTlK.DGKLEVpGpVGElNpDLLGI..ESVNAGRKs.o+up.............stpph..............puu....h+KtcshsssspshDh..GMs	.......MADKKNLAVR...SSYDDYIETVNKITPQLKNLLAQIGGDsAVKGGN........NNhsSQs-V.TAG...AssTKSKSoKChTs+sKo........pSoSo...............SsS+sS.p.oSGAP+RRTTs...ooS.hNA..hDGQIVQAVTNuGKIVYGTVR.DGQLEVRGMVGEINHDLLGI..ESVN.AGKKKsSKKh................PTsKK...........hshSSG....MRRpEpINssDsClDh..GM.h......................	0	0	0	0
+3926	PF04848	Pox_A22		Poxvirus A22 protein	Mifsud W	anon	Pfam-B_4558 (release 7.6)	Family	\N	21.00	21.00	21.00	21.10	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.82	0.71	-4.32	13	94	2012-10-03 01:22:09	2003-04-07 12:59:11	8	1	75	0	1	111	206	152.10	38	81.27	CHANGED	plICAhDlGsKNPARTllEl.ps........ss..I+llcIsKLDWS.ssWE+pVA+Dlsp....ashshVLLE+Qs+RSPasKFIYFIKGhLYs..opT+VIslsPs.....hsGsSY+sRK++SlclFLshhshFG..lss..lsch+KLDDVADSFNLAl+Yl...LsK	.............................................hIsAhDlGs+N.AhsllEs.cs.............ss.....l+..llDl......u..K.lc....ho.....pDa.c..+.pl.....s.+Dlsp.............hphssVLlERQP..cR.u..s..hl.+......h..l...a.FI.+..u..ah....h....p......s..s......s..KVIs.V..SPs..........................hsG...s.oY+-.R....K...K..pS.....V....Esh....hs....ahcs.as.......lpc....sl...s...cp.+.KhDDlADoashAhpal.......................................................................................................................	0	1	1	1
+3927	PF04584	Pox_A28		Poxvirus A28 family	Waterfield DI, Finn RD	anon	Pfam-B_4756 (release 7.5)	Family	Family of conserved Poxvirus A28 family proteins. Conserved region spans entire protein in the majority of family members.	21.40	21.40	24.50	24.50	20.70	18.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.30	15	68	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	47	0	0	50	1	139.50	60	99.61	CHANGED	MNslolFhIllATsAlClllFQhYslYENYDNIhEFNssHusLEYSKolss.stlDRpVaDPNDplaDsKpKWRCVpas.ssYVSlShFGF.pussusp....l+pFsTl-sClsaTFScuscusIaNPChsss..pSp-ClFLKSlL	..MNuLSlFFIVVATAAVCLlhlQuYSIYENYsNIKEFNAsHAAhEYSKSlGG.PuLDRRVpDsNDsIpDVKQKWRCVsYs.NuaVSASlFGF.pA-sGsN....IRKFsThppCIDaTFScshshcIaNPClsPN..sssECpFLKSVL....	0	0	0	0
+3928	PF04665	Pox_A32		Poxvirus A32 protein	Mifsud W	anon	Pfam-B_5586 (release 7.5)	Family	The A32 protein is thought to be involved in viral DNA packaging.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.68	0.70	-5.07	10	981	2012-10-05 12:31:08	2003-04-07 12:59:11	7	4	115	0	835	1034	176	165.70	48	66.54	CHANGED	Ep+FsRcSLLcsPFRMAlVGGSGSGKTsYLLSLFpTLVc+Y.KHIFLFTP....VhNsuYDuYlWPDHIpKVoopEE...LEYsLsssKpKIE+asp.upspK....t.pFLlILDDlGDhQhRS+sLlslhNaGRHlNlSlIlLCQTY+HVPlNGRsSITHaCCCNVS-SDlENhlRSMSI+GoKKpLl+slulhRuup.ppR+Vl.IIEDSVFspGEtRICYDoAD-pVltpclDhsILlsQFSHMKppLss	................................................................................................................pc.pphhpc++h+pcppp....................................................................................................................................................................IEhluK.KhQ.ua.c.........YP+R...sL.LILDD....F...A..S...H.h.K..s....R...-.Q....-...M.C.R.IL.K.....K...LR.HF.N..IS.VVICVQ.TA...KS..L.SKD.V.KR.IL.T..D.Il.L.F.P..s.h.scD..h.E.LMpESMusK.hc+cE.lWEtYKllps.......P+.oshcIH.IhsNpV........................................hlKst...............................................................................	1	782	794	835
+3929	PF04948	Pox_A51		Poxvirus A51 protein 	Finn RD	anon	Pfam-B_6937 (release 7.6)	Family	\N	19.90	19.90	20.60	20.60	18.50	18.90	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.11	0.70	-5.77	8	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	35	0	0	70	0	276.80	52	97.71	CHANGED	M-.hIlsss.Sh.+DhDll-alKssFssc..hspscNVCoKaDNllhoopoKsKllluDhPpIDpslSphYppsht..pslsRlSRFCKlltLcscKD.....alYlPtocsll..slLsIsppssssp....pCElphhsssspssI..pLp.scFsIlpss.pshhVKGsNllllIllF-EtsaPtIPLIRoISsNsVlISRHsRLHcElPscNWFKFYVEL+HsYoSuLhlllDGolLYAsuDYKTHChISKp.psp+c-lsDDCtCCYsssplplhsKp-llEpssCcsIRGGlpIplpcVGcFuASalGKYPNh-YIKIsluosYcMIsKQDplSGKptpusYlYGIA+R	..............................................................................................................................................................................................MD.lIVhslpuL.Kch.EplsalKNsFhhc...sptppsCcKlcNVhIsupoKssslIADlPhlDsulS-lhpohht..hsluRISRFsplIcl-cccc.......YsYhp..p-sls..sIloIu+ccD.........sCEllIsS.DpusssI..cLsph+hAILshs.sSFFsK...G.Nus.LlILLFD.hshsusPLLRS.losNsVlISRHpRLHcElPSpN.WFKFYlsl+psYCSlLYhVVDGSlhaAhADp+THshISKs.hhcsssINDECcCCYh-.PQI+ILDR-EMLsu..S..S.....Cchs..R+s..IhhsLs-lGcFGSSh..lGKY.EP-hIKI.ALSsutslIpspDhIsGR+taShYVYGIApR....................	0	0	0	0
+3930	PF04924	Pox_A6		Poxvirus A6 protein 	Finn RD	anon	Pfam-B_5792 (release 7.6)	Family	\N	19.70	19.70	20.00	19.80	18.30	17.70	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.43	0.70	-5.66	12	67	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	44	0	2	54	1	362.30	62	98.12	CHANGED	MDKLRslYp-FYpIS+cYLE+pTsppsssssa-sDVshhhslVPlLEpKlss.IssshoD-sllhhM+asNY+hFSFWFLKSsAVVKSVYN+Lcp-pE+p+FhplFKDlLlssQTLlSlNsMYpNlKQDTs-IVsDSKKIlEIVspl+sussEssAYKlLQsNaoFIVKTINKlLSDENYLLKlIAlFDocLloDK-KLpEY+ElFolSsESllaGI+ClS-L-lsolslp.NN..KYltFFKKlLuslILFQNssLsup+FlplVuKLYslIapphpTNspluhLlo-VLDSlKsKlSl--lKpcGVpNlQoLI+aIusN+s.YKsIlucEYhKREsslIcILQsIsscssIcasGpslDlctLlchhK-+ahp	..............................................MDKLRVLYDEFhsISK-pLERETGLosSDlDhDhDlsIFMTLVPVLEKKVCs.ITPoIcDDcIlsMMKYCsYQuFSFWFLKSGAVVKSVYNKL-.DsEKEKFlssF+DMLLNVQTLI.SLNuMYopLRQDTEDIVSDSKKIMEIVSHlRuSTsENAAYplLQpNNSFIlpTLNKILSDENYLLKIIAVFDSKLIS-KEpLNEYKpLaTISoESllYGIRCVSsLDISSVpLs...NN..KYVhFlKKhLPpIILFQNNDlNuQQFANVlSKlYoLIYpQLpoNV-VGsLLTDsl-SsKTKISVEcIKQsGINNlQSLIKFISDNKcpYKoIISEEYlu+EDcIIoILQsIlNEacIcY-spllNhR-LIshh+ERYu..........................	1	1	2	2
+3931	PF04745	Pox_A8		VITF-3 subunit protein	Waterfield DI, Finn RD	anon	Pfam-B_6036 (release 7.5)	Family	Family of Chordopoxvirus proteins composing one of the two subunits that make up VITF-3, a virally encoded complex necessary for intermediate stage transcription [1].	25.00	25.00	237.70	237.40	18.40	17.30	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.71	0.70	-5.48	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	39	0	287.30	66	98.14	CHANGED	MF-PVPDLNLEAolELGDVsI-sT+u+s+E..SsuYVSKsRRLFVH+SKD-ERKLALRFFLsRLYFLoYKElNYLFRClDsVKDVsITKKNNVIVAPYlILLTlSSKGYKLTESMIEhFFPELYNEsSKKFRFNSQIsIIQEKLGYssusYHVYEFEhYYSTVALALRsc+.....-s-lFNsRcESplVSSLSEITYRFYLIpLKSshVQWSuSTGoVINQlVNTVLlTVY-lLpKslpps+pFpCTLApEoclPlpLLlDRh-hFsKIIs-L++TNSFKISK+DKcsLLKYCp	.MF-PVPDLNLEAolELG-VNIDpTs.shl+E..souFlSRSRRLFsHRSKD-ERKLALRFFLQRLYFLsaRElpYLFRClDAVKDVoITKKNNIIVAPYIsLLTlASKGhKLTETMIEsFFPELYNEpSKKFKFNSQVsIIQEKLGYpsuNYHlYDFEsYYSTVALAIRccc.....sSs.IFNlRQEShLVSSLSEITYRFYLIpLKSDLVQWSuSTGAVINQMVNTVLITVYEhLphslcs.cspFsCoLAlESc.LPlcLL+DR.s-LFsKhIs-LK+TsSFKISKRDKDTLLKYFp.......	0	0	0	0
+3932	PF04835	Pox_A9		A9 protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4431 (release 7.6)	Family	Family of Chordopoxvirus A9 proteins. 	21.50	21.50	21.90	24.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.84	0.72	-4.06	8	68	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	1	53	0	54.00	71	55.25	CHANGED	AIDlhRHhFMYFCEs+lRPNSFWFVllRollSMlMaLlLGlsLLhISsNs-csc	..............AIDLCRHFFMYFCEQKLRPNSFWFVVVRAIASMIMYLVLGIALLYISEQDDKKN.....	0	1	1	1
+3933	PF04508	Pox_A_type_inc		Viral A-type inclusion protein repeat 	Waterfield DI, Finn RD	anon	Finn RD	Repeat	The repeat is found in the A-type inclusion protein of the Poxvirus family [1].  	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.54	0.74	-7.01	0.74	-3.68	27	453	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	22	0	1	343	0	22.90	49	16.96	CHANGED	cElc+h+p+Ip-L-cpLscspcs	.pElscL+sRIpDLERpLs-C+cs..	0	1	1	1
+3934	PF03286	Pox_Ag35		Pox virus Ag35 surface protein	Mifsud W	anon	Pfam-B_4295 (release 6.5)	Family	\N	24.10	24.10	26.20	26.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.48	0.71	-4.79	10	84	2009-09-11 15:09:14	2003-04-07 12:59:11	9	3	42	0	2	75	0	198.20	52	93.58	CHANGED	M.SWSINLu..uu.GDNFKTL-EIRAHVRSTTEssD..cssDDIFPs.....DI.................cIP.op+pP+pK+.....sTs.RK.......ssssKucKscKEKss.ttcc.psDs-K.............................TEENEs.sp..p-sscscpusSsssps......s-Ds.....................hDsSDLKlAT-sIlKDLKtLNsRVoAlSTVLEDVQAuSIoRQFTSLsKul-pL+slApsGKppVs..RKKs+s.sKK	..............M.AWSIo.p..us.oSSFpphsEIRAHLRsoA...ENpD......K.N-DIFPE.....DV...................................lIP..STcPKTKR.....sTsPRK......PAsTK+S..TKKtc-.+pplEE..E.....s...llEEhcp....sTEENSsssss..oPssGD.IsESlsAs-h-...........-.DssD-.........................poDhSDLKVATDNIVKDLK+IhoRISAVSTVLEDVQAAGISRQFTShTKuITsLucL.VopGKS.KVV..RKKVKo.CKK............	0	1	1	1
+3936	PF03336	Pox_C4_C10		Poxvirus C4/C10 protein	Mifsud W	anon	Pfam-B_3519 (release 6.5)	Family	\N	21.00	21.00	21.20	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.25	0.70	-5.66	8	127	2012-10-10 13:59:34	2003-04-07 12:59:11	8	2	33	0	1	132	15	260.00	52	96.81	CHANGED	hlplHlFo-shFcshKp-lh..lp..php......p.t..h.............pcSKplhhcsoLsc-lhspl+sl....lYcpLKslVc......sVpVcNclTllpY-+GDahsppps..ssshs+NtlshaLLlaLpps-pGGcs+lYlcssss.hlslooDlLFDKolsH-oppVcsGcKplAlhDVhlc..h..ccsllsTIcY.hsssIsLYD+EsDp.sLCYC-lp.Ipshs..s-hhphGlIsDRSGKClLVHpstclsphcc...lacSFp-lChpphh-.....tlhplppsss+sIAWSslc.sscsDpalPpsc-hYKhLpclss+p+s.ppt+l-hh...........shss---E.hahhCpVo+YYFsLPc	.........................................................................pTIKlFNp.EFDsIRN-lhpLhKhVp.......................................sss.l.pl.s...pD.s.D.I..-sIRcI....L.Y+phKN...Vc....................sl-lsssIoFhKYs...........N.ssl.....T....s.....s.h.t..YhLVIYLppsh...plKhh......aP.....Ts...p..........I.....p.o.s..........c..D.....IMFuKoLsF+.ppVhpshKhl.hhsISls.....Yp.ShspIpY..ssh...........IDIpssppsp.pLCYChIT.hDsHaL.lDlETlsVlVs+SGKCLLVNpahhhhhhpc...I.sSFsDlCMDpIF-h.spscELFoLpNDDsRNIAWDsDK.csssshWhPhT---YKFLS+Lh.hAK...ssThFDYY...........VLs.GD.T-PsTVF.FKVT+aYhNh..h.................................................	0	1	1	1
+3937	PF03287	Pox_C7_F8A		Poxvirus C7/F8A protein	Mifsud W	anon	Pfam-B_4089 (release 6.5)	Family	\N	24.10	24.10	25.50	31.90	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.80	0.71	-4.49	11	76	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	37	0	0	56	0	148.20	44	89.05	CHANGED	MGIpH-LDIalVsEslulKslpLhKGDSYGCsIclKlsspKplcFlllL+.PDWppIs-lKPIpMclNGhsl-spLl........................pcohhphIYsuslslpscos.lphaSDsccp.apctYPslpINs.KKhYclhcpGhThhaI-SPIsspDKhpahc	......MGIpHEhDI.lIsssIAL+NLpLHKGDsYGC+LcIISsshKplcF+hIl+.PDWSEIcclKsLpsasNshslcls+l........................ccohYhlIYpAslpLYscpTplLlaS..Ds-s-.aK+YYPhIsLNhhsKcYcVK-cNYossaIEaPllshcchp.hc...........	0	0	0	0
+3938	PF04701	Pox_D2		Pox virus D2 protein	Mifsud W	anon	Pfam-B_5832 (release 7.5)	Family	\N	25.00	25.00	66.70	66.50	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-11.02	0.71	-4.22	10	55	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	41	0	0	41	0	135.20	51	90.63	CHANGED	ch-lK+..LssI..ltNssllFssDlsplhsE+aIlLE+s.sGpshclHlYcssARFDN+oIa+lVKalY+sRsclL+llFPspshhESlcsLhPshTlsl...........pcsstss.hp...scs.ssKhlLLELFNSF+hGKsss...shPYYhLP	........phDIKK..ITDL..L.NusILFPDDV.pclLpEKYIVLERcsNGTPsssHIYco.hARFDNKSIYRIAKFLFhNRPDVIKLLF.....LEslEPLLPsKoINI..........ShssoEhPpL-....sPluTKlsLLELFNAFRoGtu-....PlPYYYLP....	0	0	0	0
+3939	PF00874	PRD	BglG_antitermin;	PRD domain	Declerck N, Bateman A	anon	Pfam-B_772 (release 3.0)	Domain	The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators Pfam:PF03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99, [2]) and inactive state (pdb:1tlv [4]), revealing massive structural rearrangements upon activation.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.89	0.72	-3.86	211	15913	2012-10-02 16:05:11	2003-04-07 12:59:11	15	106	2053	11	1448	9078	56	90.60	18	28.55	CHANGED	pcllphh.....cpphphph......ssthhhsLhhHlp..hslpR.lpps..........hphpsshh.pplcp.Y.sptaphspchhphlppph.shpls-sElsals.lHltss	..............................................t.thlphh.ppp.h...phph..........spthh.....sLhhHlp..hh...lp.R..lpps...............hph.p.s.s..h.h...p...p..l...p...p.......a.....spta.p...hs.p.p.hh.p....h....lpp....p..h....s.h....p..l.s.c.s.Elsals..lHhht..................	0	437	816	1106
+3940	PF04580	Pox_D3		Chordopoxvirinae D3 protein 	Waterfield DI, Finn RD	anon	Pfam-B_4684 (release 7.5)	Family	Chordopoxvirinae D3 protein conserved region.  Region occupies entire length of D3 protein.	19.90	19.90	20.30	20.10	19.60	18.60	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.61	0.70	-5.18	10	66	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	37	0	0	60	0	225.60	54	96.18	CHANGED	MDIhll+Dst.YPhhsscsNcs.FlLLGNHspFIsshLpclpp+..hhFascYtloPDchG.oLplchlsSSat..I+s+hVsV-EFIshGpshcWCspphpts....phscsDpllIaDIsahcsshWKRIlhlpCPshlssphEp............FlTNPa.lhppsp.......clF+NllLRStlNshIFs.psSsLcpLLsH.Ilophsl-+h..pslls...ac-sssl+LlppCY-Rs+F+AFVYAWFsuQl.sNsphENEKVc+sacpVpchI	...................MDIFI.VKDNK.YPKVDNDDNEV.FILLGNHNDFI+sKLTKLKE+...VFFS-YIVTPDsYG.SLCVELNGSSFQ..HGGRYIEVEEFIDuGRQVRWCSsSNHIS....cDhHTDKFlIYDIYTFD..uFKNKRLV.FVQVPsSLGD..DS............aLTNPh.L....S.......PYY+NuVARQMVNsMIFN.pDSFLKYLLEHLIRSHYRVSKH..ITIV+...YKDT-ELNLTRICYNRDKFKAFVFAWF......NGVsENEKVLDTYKKVSsLI..........	1	0	0	0
+3941	PF03288	Pox_D5		Poxvirus D5 protein-like	Mifsud W	anon	Pfam-B_4009 (release 6.5)	Domain	This family includes D5 from Poxviruses which is necessary for viral DNA replication, and is a nucleic acid independent nucleoside triphosphatase. Members of this family are also found outside of poxviruses. This domain is a DNA-binding winged HTH domain.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.96	0.72	-3.72	41	1059	2012-10-04 14:01:12	2003-04-07 12:59:11	11	32	639	6	337	979	69	91.70	20	16.60	CHANGED	pssDslh-Fhtphhs..............tu.hlPs.phlattYhpahccpGath.......LstppFppclsp.hhpt...s.....ahp++p+..................sthspthhphhhhp-h.s	...........................................................ps-shhtFht.h..........................................h..h.hsp..p.LYcsYhtahppp..Gats.......hohppFtpslpp.hhp.......t..........apc+p............................................................................................	0	258	294	317
+3942	PF04805	Pox_E10		E10-like protein conserved region	waterfield DI, Finn RD	anon	Pfam-B_6357 (release 7.5)	Family	Family of poxvirus proteins.	25.60	25.60	25.70	94.90	25.00	25.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.47	0.72	-4.45	11	59	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	43	21	69.90	74	73.15	CHANGED	slEtCK++LYsIssTLPCssCRtHApcAIpcNNlMSSsDlNYIYaFFIuLFNNLssDspa+.IDlpKVpPL	.NIEuCKRKLYTIVSTLPCPACRRHAThAIE-NNlMSSsDLNYIYYFFI+LFNNLASDPKYs.IDlsKV+PL.	0	0	0	0
+3943	PF04497	Pox_E2-like	Pox_E2;	Poxviridae protein 	Finn RD	anon	Pfam-B_3979 (release 7.5)	Family	This family of proteins is restricted to Poxviridae.  It contains a number of differently named uncharacterised proteins.	30.00	30.00	32.80	32.70	29.70	28.10	hmmbuild  -o /dev/null HMM SEED	728	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.09	0.70	-6.50	27	184	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	43	0	0	167	0	610.30	29	95.71	CHANGED	M...h..spplRcuhtphtsp....................phsaccLshpc..shpLlthGlH.spLPcphYscsl.chs.splhhFcPcpVphhDLlpllpppps.s..pphtstltaa+ppllppsshp.llp+hlphhhl.s-DDlch....llsc...t.hss.hLhplNsp.ltph..hhhScptlcplhpp.shphhshLYp+.s.hshphLhphhtcasIsPsNpulhp.p..shstsl-llpphsppp.......hlchlspplhsscphhphlh......IhtsplsshhshspcaLhsphsc............GlhsshhFs...........hspht..ptlocc..........phphIscaIshYchp..................uplhsph.c-hlpcphshtlh....pst.hlphhphshpsptshhtshp.sh--ll...........paLDsltlpsh.chphs.l..-.................hhhs.s.haN..spllc.hlpphuhsptKhptLhht..............hs.s.tshthhhphht..psshhhsst.hhsolh.h..............ht..t.hhhh...p...t..p.sh.ststpsphp.h..h.p..thph.hht........p.........................s.th.ss-scllsplaDlsphApaGll.hshhhhss.WhPlhshl........................phsphssssph.psslhpls.schscatsh........shst.lsshasthsshhsslhhYllsuhhh.....s.pp..thppFlppllsshhcGhtlt.........hspslpsss.p.hhclcphls.ts.ssh.hhhphhL+ssltlhccl	......................M..h..sp.hR+Ah.c..s+....................phshthlppcc..tlsLlchGhH.shLPKsLY.psl.p.s..plhhF.PchlsshDll.pslpp.p.p.s..-hhtshl.aHKsslhhsu.hs.llhhhh.Y.ll.ocsDlca..........lhpp....ss.hthhL.hINt..l.hh..hpho.sEIlsllpc.shhhh..lYpp.s.lD.chlhph.DcYsIsPlpsulhc.p..s.EhhIcllhthshsp.......hlshlsps.hhpsshhphIhs.....hhpt+lshhhshlp-aLpshh.D.......................sIhushhFp...................lshhs......lTts.............................E..alph.hshYshh...................................hp.hs...p.Dhlh.c.shpIs......poss.l.hhphP..hp..p.shlhp.p.ph.DIl...........palDphchso..chuh-sl..-.................hhho.ohhhN..ssllphhhhp.h.h.hhhhhLhh...............hshpp..sshhLpth...+Ghhhh.sh.slhoh.................h.h.hp..ph.....p.hpsc.lsh.sshppsh.h.hhphpul...............................................hsp-ctlh.plaDlsRhA.aGhh..s.hh.ps.WsPlsphl........................chp-hhs.t+..phsllslhsp..hchps.........ph..slss..AtlshhhsTll.Yllhs.hh.....slpp...sccFV.pllphhhcuhtl..........L.p.lpsss.h..pclc-hsspGs.ss..aLh+.plphh..lh-cl.........................................................................................................	0	0	0	0
+3944	PF04656	Pox_E6		Pox virus E6 protein	Waterfield DI, Finn RD	anon	Pfam-B_4392 (release 7.5)	Family	Family of pox virus E6 proteins.	25.00	25.00	25.70	195.00	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.73	0.70	-6.31	11	74	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	45	0	0	63	0	552.40	72	100.00	CHANGED	MDFIRRKYLIYTIENcIDFLRsElhsKlSNFoLNHVLAlKYLlhsFs+sVlTKDVLuNsNFaVFLHhV+CscVY-hVL+pSFDlPsLYlKuLlKNYshFschIpsYKphspcLl.Dc+FlElschusphp-lIGVNYDhtLNPLFHpGEPI+sMEIIYuKLFKKTcF++V+KlpVlRLLIWAYLoKpDTGhcFsDNDsQDlYTLaQKoGs.llpS-MTEpFKEYIFs..ss+TSYWlWLpEsIhNDsclYhctsApoMY-KlLSYIYSElKQGRVNKNMLKLVYlFEsDp.I+ullLpIIYGVPGDILSIIDo+DEsWKpYFluFYK-NFIDG+TFsSspoF.-DLF+VVA+IDPEYFDsc+.IhSlFcpcP-plchFDchDINsTYlSplIYpTpDlsLpslEchptCQIYN-DTcYaIKEYNTYLYLsE-DPhVl.cGhLsKLSsl.sps++..hoLFScsILKYYlDG+LAslGLVLssYcsDlll+lloHLKClEDVTsFlcausC+NsSllPSllRTILuNFNluIIlLFp+FLRENlaaVEpaLD+opHLTpNDKKYILplIppGRS	.MDFIRRKYLIYTVENNIDFLKDDsLSKVNNFTLNHVLALKYLVSNFPQHVITKDVLANTNFFVFlHMVRCCKVYEAVLRHAFDAPTLYVKALTKNYLSFSNAIQSYKETVHKLTQDEKFLEVAcYh-ELGELIGVNYDLVLNPLFHGGEPIKDMEIIFlKLFKKTDFKsVKKLSVIRLLIWAYLSKKDTGIEFADNDRQDIYTLFQpT.GR.IVHSNLTETFRDYIFP..GDKTSYWVWLNESIANDADIVLNRsAITMYDKI...LSYIYSEIKQGRVNKNMLKLVYIFEPEKDIRELLLEIIYDIPGDILSIIDuKNDDWKKYFISFYKuNFINGNTFISDRTFN-DLFRVVVpIDPEYFDNER.IhSLFSTSA.s-IKRFDELDINNSYISNIIYEVNDITL-TMD-MKKCQIFNEDTsYYlKEYNTYLFLpEsDPMVI-NGILKKLSSIKoKSRR..LNLFSKNILKYYLDGQLARLGLVLDDYKGDLLVKhIsHLKsVEDVSAFVRFSTcKNPSILPSLI+TILASYNISIIVLFQ+FLRDNLYHVEcFLDKSlHLTKsDKKYILQLIRHGRS.	0	0	0	0
+3945	PF03394	Pox_E8		Poxvirus E8 protein	Mifsud W	anon	Pfam-B_3759 (release 6.6)	Family	\N	20.50	20.50	20.70	89.40	20.20	16.80	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.68	0.70	-5.00	8	66	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	41	0	0	52	0	236.70	77	85.75	CHANGED	h+NTYLYHNYAYGWIPETAlWSSRaAsLDlTDYYPITLGLLKKFEFMhSLa+GP...s.sYpsKINTEFlupGSFhGRalsaa++FoILPTcEFISFLLLTSIPIYNILFaFKsTpFDhsKHoLFuuhYosss+HlELA+Yh++uGDYKPLFu+Lc-..cslYo.....u...shPlshtsll+spsPsu.p.ssS.DYETLANLSAILYaTcYDPVLhFLhFYlPGlSVTTKITPuVEYLMcKLsLsKcDVsLl	MKNTYLFDNYAYGWIPETAIWSSRYANLDASDYYPISLGLLKKFEFLMSLYKGP...IPVYEEKVNTEFIANGSFSGRYVSYLRKFSALPTNEFISFLLLTSIPIYNILFWFKNTQFDITKHTLFRYVYTDNsKHLALARYh+QTGDYKPLFSRLKE..NYIFT......G...PVPIGI+DIsHPNLSRA.R.SPS.DYETLANISTILYFTKYDPVLMFLLFYVPGYSITTKITPAVEYLMDKLsLTKsDVpLL.	0	0	0	0
+3946	PF04943	Pox_F11		Poxvirus F11 protein	Finn RD	anon	Pfam-B_6911 (release 7.6)	Family	The protein F11 is an early virus protein.	24.10	24.10	24.10	24.20	20.30	24.00	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.06	0.70	-5.60	7	107	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	36	0	1	85	0	197.40	38	88.29	CHANGED	o.tphss......hslp.p............Phhhlspussp.l....Lhsslalp..slcslhspsstllscssphpp.s..p..apht.l.l.sshhhchlhDtpsaFcls-shll+LcHGshahptshasssshuFsAlICl+NpGhSulhVsposhlppshppGssllhRSspulphLPQIuGcuhYLIlplsPTcchhcphh.slhssspspsu.........p.phthsuppc+cshchlsslIphpl.LEchhhchs....hhpEhtshYsslhh........................................pppppp.lpshhppscshhppuhssh.hh..........tpsspssh+cchLhtthp.+Dlp.lhsshsp...............laschtclhpclsshls..................tps-hlppaIhthlspspssh.psplhpsL.....hslsslsahl	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+3947	PF03337	Pox_F12L		Poxvirus F12L protein	Mifsud W	anon	Pfam-B_3082 (release 6.5)	Family	\N	25.00	25.00	87.60	87.40	24.50	17.70	hmmbuild  -o /dev/null HMM SEED	651	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.27	0.70	-6.61	11	87	2012-10-02 01:06:00	2003-04-07 12:59:11	8	1	43	0	0	83	0	615.20	60	99.36	CHANGED	shhsplpssss..t....plsssLpch.chsllLA+spcGKGlllhusNlptspsh...lslopLcllulsthl-shssPstPhspLhIsuh-o-.saYSPcTSpo.PLlDIL++Ruppps..-LtpAl.tc.hs.pussSloEINpWhspsGLt+YRFlsacDt+thph....sphTllD-MsIsaIGpHhIWVKDh.sYsRPElDI.LsaDlcsluptspWucl.pshstphhplhuhhlpuhlos..sGPplYMIoTY.PG+sFhshsSsK.Llp-FLcWlp-.hhtshp....................TlsLlGahSSlFDhPLL+ssasps.pGWshl....usssllScsGh+lhllDhupFuhuh.olp-YCpaWsusshshscD..llocpEs+hphchlccsuscsspsLasAshsppssLsplhsssshhtFssL-DMllspuhhhuApp.stthYhPstssshshlppulptctVpoh..ssss..t.hppa+L+SllclltsphYPlG+PpaVpp.hscGKLYIALCcVTh+ssl+IPllassc.sEsshoF.ssLTSVDIphAt+lGGYpI+.lsALpW-cShpl.+sslpchhstlscl...spospLhsplsp....scLh.pspss.hsp..hl..atAFAASYCRtplHslIcclDSHalGsaVh+HsYpclalpsssststshLSphhcl	..........................................................................s...QhLMKTAN......NYETIEILRNYLRLYIILARNEEG+GILIYDDNIDSlMSM...MNIT+LEVIGLT.HCTKLRSSPPIP...MSRLFMDEIDHE.SYYSPKTScY.PLIDIIRKRSHEQG..DIALAL.E+.Y.sIEN..TDSISEINEWLSSKGLACYRFVKFND.Y.RKQhhh+.ho+tTIVDSMIIGHIGHHYIWIKNLETYTRPEIDV.LPFDIKhISRDELWARI.SSSLDQTHIKTIAVSVYGAITD..NGPhPYMISTY.PGNTFVNFNSVKsLILsFLDWIKD.IM.TSTR....................TIILVGYMSNLFDIPLLTVYWPNN.CGWKIY.....NNpLISSDGARVIWMDAYKFSCGL.SLQDYCYHWGSK.PESRPFD..LIKKsDAKRNhKSlVKESMsSLKSLYEAFcTQSGALEVLMSPCRM.FSFSRIEDMFLTSVINRVScNTGMGMYYPTNDIssLFIESSICLDYIIVNNQcS.....NKYRIKSVLDIISSKQYPAGRPNYVKN..GTKGKLYIALCKVTVP.TNDHIPVVYHDD..DNTTTFITVLTSVDIETAhR.AGYSIVELGALQWD-NIPcLK-..sLLDSIKhIYDL.NssTTN....NLLEQLIE............N.INFNNSSII.LFYTFAISYCRAFIYSIMETIDshYISQF....SYKELYlsSSaKDINEsMSQMVKL...................	0	0	0	0
+3948	PF04596	Pox_F15		Poxvirus protein F15	Mifsud W	anon	Pfam-B_5182 (release 7.5)	Family	\N	25.00	25.00	167.60	167.30	16.70	16.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.85	0.71	-4.58	11	51	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	38	0	0	33	0	136.20	68	88.25	CHANGED	LsPF+sMs+IKINpc-NClLGNRCFVKlscV+ahPpsuls....Topolph+sacFTLsELLYSPFHFpQsQaQYLhPuFVLpCI-EAs+NpppC+YChss+ssc..suLNINIFlPThspphYlIIGLRIKsFWsssFcIE	M+PFKNMNKIsINpcDNCILANRCFVKIDTsRYIPssSIs....oSshIRIRNHDFTLSELLYSPFHFQQPQFQYLLPGFVLTCIDKsoKppKcCKYCISNRGDD..DSLSINlFIPTINKSIYIIIGLRhKsFWKsKFEIE.	0	0	0	0
+3949	PF04708	Pox_F16		Poxvirus F16 protein	Mifsud W	anon	Pfam-B_5863 (release 7.5)	Family	\N	25.00	25.00	25.40	33.50	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.49	0.70	-5.06	9	65	2009-09-11 09:28:37	2003-04-07 12:59:11	7	1	39	0	0	56	0	212.30	56	91.97	CHANGED	cpAAIlTSLlSLFDsSlpaQlchC+pYCp.LuhpVlhEl+EFGYIs-csLpocpW.ssltsssIshlVFYQlKQLoISscpLYshhh+.sc.ssl+lYFV+DsLsFDG..hPPoF+plshslphtsRKKl+DlIsLlshpTsscpllpcFlpsNFGsVctLLpllcpssLWlphhLsppcp+t..................hshhpa+pFlsKl+clct.hpsp.l-cICsshpsIsl	..............M.KVVIVTSVuSLLDASIQFQKTACRHHCNYLSMQlVKEI-EFGTINEKNLEFcTWKDVIQNDEIDALVFYRVKQISISsGVLYcSMMR.NRTKPISMYFVRDCLAFDG..sPPSFRMTSCNINAYNRsKIKDLIIL.MNMKT.CNKKIIGEFIIDNFGSVcuLLSIINSNVTWVTSVINNSNGRGINIRVS........NNKMLTITSFRRFVNKLKhYKTTKCsSQLDNLCT-hNKMcI....	0	0	0	0
+3950	PF04767	Pox_F17		DNA-binding 11 kDa phosphoprotein	Waterfield DI, Finn RD	anon	Pfam-B_6128 (release 7.5)	Family	Family of poxvirus proteins required for virus morphogenesis. Protein function necessary for proteolytic processing of the major viral structural proteins, P4a and P4b [1]. 	25.00	25.00	32.90	32.20	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.27	0.72	-3.74	11	57	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	37	0	95.10	63	94.23	CHANGED	hhhcoPFhlsTc.EGRYLVLKAlKlCslRTV-Ccus+ASCVLKVEKP.susC-R..ssoPs.Rstht.......osPs.+sssplPFMRTNhLpsl.usNR.NssuRlLu	.u..AHTPFYINTK.EGRYLVLKAVKVCDVRTVECEGS.....KASCVLKVDKP.SssC.ERR......PoSPu.RCtRh.......ssPu.....pQVPFMRTsMLpshFAsNR.NV.uSRlL.p	0	0	0	0
+3951	PF04599	Pox_G5		Poxvirus G5 protein	Mifsud W	anon	Pfam-B_5216 (release 7.5)	Family	This protein has been predicted to be related to the FEN-1 endonuclease [1].	20.10	20.10	45.60	45.30	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.60	0.70	-5.78	11	78	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	70	4	413.50	57	96.90	CHANGED	MGIKNLKoLLLcptsLppl...csh.+s.hstIFVDTMSlFholAasVssl--LpspFhcalpta.ppsG+VTLFlDRGsIsIKcsLREKR.+suhcNThKRKphElcp.........LpstIstLslsDhhYEEhKT-lcL+IcKLpFa.FLuspsNlKhs.L-csLstl...-sVsIlYCDslDAEFVMCpcAKcls.poGpWPllISoDQDTLLhuSsDshsKI..ItohsphYpalPssco+YLoKLlsLsNGCDaFsGLYGhsITpKoLpp..IpL....F-DFol-Nll+....SLshKNYsp.......Ktos+hlD.....lDpIIcFIscY.................osLDcslY.pppsssslolQEFlFoALsp+Wpphcsohlc.ssulhssLhslLc..P++cIsps-lpplpphlpcs.hp++sslssIpolssIFGYchspsssllhGIhshpslhLsacc...pFYFNspsIIc	...MGIKNLKSLLLEs+SLTlL...D-slh+laNGIFVDTMSIYIAVApCVpNLEELsolFlKYVNuWl..K..KuGHVTLFIDRGSI+IKQsVRDKR.RKhSK.TpcRKhLELEK..............................................................ssu-Ip..NV.ouhMtEEIKAEhQLKIDKLoFQIYLSDuDNIKho.LNElLT+h.psENVTlaYCDchDAEFVMCLEAKspapoTGEWPLIISTDQDTMLFuSsDsHPKh..IKslTQLFKFlPoAEssYLuKLTALVNGCDFFPGLYGtSITssNLNK..IQL....FoDFTIDNIVs....SLA...IKNYaR............K.TNosVD.....VcNIVTFINcY.................ANLDD.VY.ualP..PCQCTVQEFIFSALcEKWNcF.....KsSYLc.sVPLsCpLhYALE..PRKEIcVSEVKTLuohIDh-..NsKscI-sIKSIoSIFGYuscN..ss..oI.VFGI.hK.cNLLLulNs...oFYFNsollI.o................	0	0	0	0
+3952	PF04787	Pox_H7		Late protein H7	Waterfield DI, Finn RD	anon	Pfam-B_6266 (release 7.5)	Family	Family of poxvirus late H7 proteins.	22.10	22.10	22.40	29.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.76	0.71	-4.40	9	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	53	0	142.60	56	98.71	CHANGED	MDc+L+oluhThFpGELoThDIhsLthalhsppPp-TlFShc.csspFhIDFcY.DssLASsYlspphpsI.s-cYhsaushIAcELTNh-IIp-DlssYIpsSc+LKRhIKhY+s...pKps++IppssK+LKlAhp+GlDY-YIK-sh	...........MDKRhKSLAMTuFaGELsTLDIMALIMpIFK+HPNNTIFSVD.+.DGpFhIDFEY.DsYKA........SpYLDlsLTPIouDECKoHASSIAcpLsssDIIKEDIu-YIKToP+LKRFIKKYR....NRScsRIScDocKLKIALuKGIDYEYIKDAC........	1	0	0	0
+3953	PF03289	Pox_I1		Poxvirus protein I1	Mifsud W	anon	Pfam-B_4306 (release 6.5)	Family	\N	25.00	25.00	184.70	184.50	19.20	17.70	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.12	0.70	-5.59	11	65	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	42	0	0	54	0	307.60	73	99.43	CHANGED	MEp..-QLVLNSISA+ALKuYhsoKIs-hVDELVs+KasQKKKSpsK+hEsRIPlDLI+psFV++FpLcsY+sGlLsSLIsSLVENNYFop.DGKLs-sucpELVLsDlEK+ILupIs+sSsLYIDluDVKsLAuRLKssAssFpFssppYhLEsDKlE-lINpLs+NssIhLDEKsSlKDShYhls-ELL-VLKsRLFRCPQVKDNhISRTRLYDYFsRlTKp-EsKIYVILKDt+IAcILGIETVplGsFlYTKHShLlsoISuplDRYSK+Fp-sFYpsIAEaV..KDNEKlNVSKVVEsLhVPslph-t...E	.s.EhEDQLVFNSISARALKAYFTAKINEMVDELVTRKCPQKKKSQAKKPElRIPVDLVKSSFVKKFGLsNY.GGILISLINSLVENNFFTK.DGKLDDTGKKELVLTDVEKRILNsIDKSSPLYIDISDVKVLAARLKRSATpFsFNGHTY+LENDKIEDLINQLVKDEuIQLDEKSSIKDSMYVIPDELIDVLKTRLFRSPQVKDNIISRTRLYDYFTRVTKRDESSIYVILKDPRIAsILSLETVKhGAFhYTKHSMLTNAISS+VDRYSKKFQESFYEDIAEFV..KENERVNVSRVVECLTVPNITIuSNs.E..	0	0	0	0
+3954	PF04661	Pox_I3		Poxvirus I3 ssDNA-binding protein	Mifsud W	anon	Pfam-B_5571 (release 7.5)	Family	\N	18.60	18.60	18.80	18.90	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.80	0.70	-5.60	11	69	2009-09-14 12:26:09	2003-04-07 12:59:11	7	1	43	0	0	57	0	259.30	58	95.83	CHANGED	ssphppssscsst.hTCssslEasKSLSpSspKsIEuVpLosSQYPSCSsIsIsLs-oLuSKhsSsaIhlEGEuKIY+NKKsstpu......-sYFLKI+PouASPhLYQLLEsIYsNI+csp+lPsSLssl.slssh-EKTFpcGslYI..NKhsGAllEYpssG.sputlpolscElEsLuKRDtQhuKsIlsPIVFYRsuspsKVTFALKKlIh-R-hossVlDlsGcsp+lsMu.....Eo....sEE-hsRGLGll-..pD.........csh-E--t-..poLFNV	......................ts.p.csssuuDSlpTCuGVIEYAKSISKSNs..KCIEhVTLsuSQ.YssCSSISI+LT-SL.SSpMTSTFIhLEGEoKlYKNKucpsRS......DGYFLKI.KlTAASPMLYQLLEuVYGNIKcpcRIPsSL+uL.sVETIsEKTFKDEs.IFI..NKLNGAhVEYlSsG.ppSIlRSI-sELEuLSKR-+QlAKAIIsPlVFYRSGsETKITFALKKLII-REssANVIGLsG-SERVSMT.....Es....sEEDluRsLGlVDl.-D.........EhcEDsDcE..cslFNV.......................	2	0	0	0
+3955	PF04713	Pox_I5		Poxvirus protein I5	Mifsud W	anon	Pfam-B_5901 (release 7.5)	Family	\N	25.00	25.00	73.10	72.90	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.36	0.72	-4.27	11	51	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	32	0	76.80	53	97.05	CHANGED	hlss+ElhosIGlTlLhllMlloGuALlhKplsP.a+hlshRShshsRVlshLEalulllFIPGTlsLYuAYl+pLhh	...MhsAhslLoAIGITlLMLLMVISGuAhIlKclsP.pclhoMpSlpFNRsVTIhcYlulhIaIPGTIILYusYlKoLh...	0	0	0	0
+3956	PF04595	Pox_I6		Poxvirus I6-like family	Mifsud W	anon	Pfam-B_5073 (release 7.5) & Pfam-B_6224 (release 8.0)	Family	This family includes I6 proteins as well as the related F5L proteins.	20.80	20.80	37.30	34.40	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.89	0.70	-5.68	13	110	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	43	0	0	95	0	309.40	41	87.11	CHANGED	+pss..............ISFsFss.FYYsN-sLFsKPpNoL-DVsKSlllhpoFcYEpaVIpull+hL..+thualhDlaFlPlGWLsG....t--s....sspHlsl+...llh.oss..htsl+spl+-hLuhaslhshsl...hps-pclsIspFshsts....hPssVl.......ShaPFDs-t.lLlVlFFGpapDuYCGIoY.sss+-pl.tllphLtPhVuElplloD-lsRFsol+lhss..pss+tFPcsp.......ltoICEll+tF-cpcFsssssss.s....shssalPK+lVSllDLPSsV-I+CtScsGlDalTHIssK+LsslLlIsKDsFl+ssohsGTFKKENllW+GpYTYR......Ihc	................s...hIpaslDs.hahCscslho+.spT...h.cpllhhto.shpphhIpuhIKhl........hslhhlslu.Lp.....h-Ds....s.oHlh.t...lIh.soh...ISlKuplI-hhs.hshhshsh...hpschchpIsoFslssS....hPhphI.......pahPFsTD.....hhahG.hpc.hsG.sY................Ph.S.h..lSsphsRho.l+.hNs..hSshhFspNh.......lpsICE...pa-ths.sss..po.o......sups.lspclsShhs.....plps.scsssDa.T.hNscpLhhIllI.........Th.uhhlh..llhtuIhhY+............	1	0	0	0
+3958	PF03338	Pox_J1		Poxvirus J1 protein	Mifsud W	anon	Pfam-B_3556 (release 6.5)	Family	\N	20.70	20.70	21.70	76.40	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.79	0.71	-4.51	12	67	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	48	0	0	46	0	143.40	63	94.92	CHANGED	MDH.ppYLLThFLp-D-SFF+YluppsD-pAhuDlpsIsphLDFLLulLIRSK-KLEulGahYEPLSEp.a+slh-Fp.Dh+sL+pLFs+hsl.phs.spplpls+GYluDFVlSlhRLp+phths.ss..psspYIDPpcshthsNlluILp	MDH.sQYLLTMFFsDDDSFFKYLAuQDDEouLSDIhpITpYLDFLLhLLIpSKsKLEAVGHCYESLSEE.YRpLs+FT.D.p-FK+LFNKlPI..Vo.DuRV+LNKGYLhDFVISLMRhKKEsuLs.ossh-PlRYIDPR+DIuFuNlhsIL+.	1	0	0	0
+3959	PF03339	Pox_L3_FP4		Poxvirus L3/FP4 protein	Mifsud W	anon	Pfam-B_3380 (release 6.5)	Family	\N	25.00	25.00	30.90	156.20	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.95	0.70	-5.97	5	71	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	43	0	0	64	0	314.20	61	90.71	CHANGED	MptNNtsp-sscspspsplPps.s.ppsppshh....-..cFlEpRLCsYE+Eps.hph-ChluhhaslpKQVscE.......EssCWlELSuLV+u+KALGFPLlYusKcaoa.G+sLYFEpFKs...s+Vp+LTsso+ClsDsllFQIVlILYSLYK+sIaSD-FlFDLVSIPRSTIohSVNQLVFslsTDsLVVLSls.TRLY+AcLPQSCYLsYlau+ssLA.++shEooNY.FFEWFI+NHlchLo+QslDIFKlKK+YlTsspIsRLsEPGTLVYVh+-DhalhGITLT-VSloDNVRVLFSsDGt..slLEIDDFSlcDVFsAGELlsRSQsooI	..................t.+hNsppRh.p.s.hsps+sc.pss.ss.+pcNK..CR-......EsuDFINIRLCAYEKEYC...NDGYLSsA.YYMLKQVDDE.......EhSCWuELSSLVRSRKAVGFPLLKuAKRI.S+....G.S.MLYFEQFKN....oKVV+LTP.QlK..CLsDoVIFQsVVILYSMYKRsIYS.NEFCFDLVSIPRTNIVFSVNQLMFNICTDlLVVLSICGNRLYRTNLPQSCYLNFIHuH.ETIA.RRGY...E+SNY.FFEWLIKNHlSLLTKQshDI.hKVKKKYATGAPVNRLLEPGTLVYVP.KEDhYalGISLTDVSISDNVRVLFSTDG...hVLEIEDFNI+clFMAGEhFVRSQSSTI...	0	0	0	0
+3960	PF00485	PRK		Phosphoribulokinase / Uridine kinase family	Finn RD	anon	Prosite	Domain	In Arabidopsis the region carries two binding domains, a phosphoribosylpyrophosphate-binding domain and, at the very C-terminus, a uracil-binding domain.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.17	0.71	-4.75	12	8151	2012-10-05 12:31:08	2003-04-07 12:59:11	13	32	4282	57	1728	5333	1269	168.80	27	60.59	CHANGED	lIulsGsSGuGpoost+phsplFst..l.sh...............hsuhhphsps..chpht-cpsttspphoahuPcANsFDLhhphh+shtputsscp.hYsHsssptss...........pph.tssclLhhEGLHuhhspc...ltpLhDhplhlsss.slchhpKlpRDhspRG+ohEulhsoI..tRhPDassYIsPQhppsDlshpplPsstsu	...........................................................................................lIul.uGusuuG.....KoT.hu....ptlhp.h...lt.t.......ht...................................h..l.spD...s..a..h..h...s..t..p..h..h.......p.....c...t...h........h...t.....t.....t...h....s...h.......t.......t...P.....p......uh....Dh....p........h...L..h....p.h...l....p...p....l....t......p.........G.........p.......s....l....p..h..........P...h...Y....s.....ah....h.....t...s.hh..............................tp.....h...h..p..s.....s..c...l..l.IlE...G....l......h.......s...h.......t...s...tt..........................l..p.c...h.h.D...h...pl.....a.............V.............D.............s.............s...........................-..............l.............p.............h.............h.p+..............l........RD.h.........R.s.......h...s..h...p....tl...h..tp..........h...hhh.....a.t..a..l.tP..p..hphscl.h.........h.............................................................................................................................	0	527	1013	1414
+3961	PF04872	Pox_L5		Poxvirus L5 protein family	Kerrison ND	anon	Pfam-B_6088 (release 7.6)	Family	This family includes variola (smallpox) and vaccinia virus L5 proteins. However, not all  proteins in this family are called L5.  L5 is thought to contain a  metal-binding region [1].	21.90	21.90	22.10	22.70	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.66	0.72	-4.34	12	65	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	0	0	46	0	76.90	55	61.63	CHANGED	ElhhhFp.+s+hs.sPI-ph.pco.LhCctstLhI.sLP..ssphsALulstpPIshpsCcsLLpSING.SppVSLsDlLpR	.............ELsMhFh.Kp+lP.DP.ID+l.c+usLuC--DKLMIhGLP.hsspssALSIN.u+PIVYKcCscLL+SING.SQ.VSLNDlLRR...	0	0	0	0
+3962	PF03356	Pox_LP_H2		Viral late protein H2	Finn RD	anon	Pfam-B_3929 (release 6.5)	Family	All Members of this family show similarity to the vaccinia virus late protein H2. This protein is often referred to by its gene name of H2R. Members from this family all belong to the viral taxon Poxviridae.	21.40	21.40	21.40	76.20	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.95	0.71	-4.61	12	119	2009-11-17 14:52:54	2003-04-07 12:59:11	10	1	51	0	0	56	0	179.90	64	97.56	CHANGED	MDcTTLsVNGlEL-YsRp+tscslphA+sSTlhFFlllLhlSslLhaaQsScNslhsELs+YtRIKsslpuW+PLVpuKT+lES-RGRhhuhs.+sDhFpFpClDFGsYalPlRLDppTFLPQAIRRGpGDGWMl+KAuchDsSAQQFCEYllts+usNsITCGhcMhsclGYSGYF.suHWCushhsll	.MDKTTLoVNuspLEYlREKtscGIRuAKsSTlhFFVLILAlSuLLLWFQsSDNSlFuELsKYsRIKNsVpuW+PLV-SKTKLESD+GRLhAAG.+D-lFpFpCVDFGuYalPlRLDpsTFLPQAIRRGsGDGWMVKKAsKVDPSAQQFC-YLI+s+ScNVITCGscMhspLGYSGYFhssHWCSsh.sh....	2	0	0	0
+3963	PF04887	Pox_M2		Poxvirus M2 protein	Kerrison ND	anon	Pfam-B_6168 (release 7.6)	Family	This family includes M2 protein from variola virus.  The function of this protein is not known.	25.00	25.00	64.90	64.60	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.38	0.71	-5.00	4	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	26	0	0	40	0	194.80	75	88.90	CHANGED	pCsopcYRYW.LAupLTIGLsYsI.Ep..tEC+hc....s+hushllTGYGLpIshpITs.lspphVAuuEGhsssNpLslLLFhspchoc.tssl....plTITCh-h-CDssshcpsLssplpKN...-lhIhGSClTCVsL-T.Pspl......Nshhs+PhShhltcssuYohR.....sapcchspC.lDhccluYslC.+p	.........CPPRQDYRYWYFAAELTIGVNYDINSTIIGECHMSESYIDRNANIVLTGYGLEINMTIMD.TDQRFVAAAEGVGKDNKLSVhLFTTQRLDK...VHHNI....SVTITCMEMNCGTTKYc.SDLPESI.H+pSSCDITINGSCVTCVNLETDPTKI......NPHYLH.PKDKYLYHNScYuMRGSYGVTFIDELN...QCLLDIKELSYDICYRE......	0	0	0	0
+3964	PF03341	Pox_mRNA-cap		Poxvirus mRNA capping enzyme, small subunit	Mifsud W	anon	Pfam-B_3728 (release 6.5)	Family	The small subunit of the poxvirus mRNA capping enzyme has been found to have a structure which suggests that it started life as an RNA cap 2-prime O-methyltransferase. It has subsequently evolved to a catalytically inactive form that has been retained in order to help stabilise the large subunit, D1, and to enhance its methyltransferase activity through an allosteric mechanism [2].	25.00	25.00	45.50	45.40	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.72	0.70	-5.36	9	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	42	4	0	43	0	279.60	73	99.50	CHANGED	h-pltc.I+-GltshhPFY-oLP-LsLshGKs.LPSLEYGANYFLQLS+VNDLNRhsTDhLSLaTHDLhhsEoDLEKVYE.hsIcSVKoYGKoI+ADAVVsDLSA+NKLFKKERshlKSNNaLsENNLYluDYcMlTFEVFRPLF-huoEKaCIlKLPTLFGRsllsslRVYCSLFKsVRLaKssuDSWLKDSAIMVspcsaptNlscFhoalRcsTKSssW+DuNN.VpFslLcssV-+EFI-KFLsFSspVYEuLYYVHSLLYsSMTSEsKSIENEaQ+KLlKLLh	..MDcIsKNIREGsHVLLPFYEoLPELNLoLGKSPLPSLEYGANYFLQlSRVNDLNRMPTDMLpLFTHDlMlPEoDL-KVYEILpIsSVK.YGRShKADAVVADLSARNKLFK+ER-AIKSNNaLTENNLYISDYKMLTF-VFRPLFDhssEKYCIIKLPTLFGRsVIDThRlYCSLFKsVRLhKCVSDSWLKDSAIMVAS-lpKKNlDhFMSHV+SVTKSuuWKDsNs.VQFSILp-PVDoEFIsKFL-FSsRVYEALYYVHSLLYSSMTS-SKSIENcaQR+LlKLLL..	0	0	0	0
+3966	PF03213	Pox_P35		Poxvirus P35 protein	Mifsud W	anon	Pfam-B_2785 (release 6.5)	Family	\N	19.20	19.20	19.20	20.10	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.03	0.70	-5.43	12	130	2012-10-03 05:28:31	2003-04-07 12:59:11	9	3	65	0	1	104	12	279.60	48	99.48	CHANGED	MAtsp.....clslYVIPll.GRssp-VlPphct...h..tchcslKc..........ss...psp.thphs............+hh.Wp......Gsl-s...ac-.......YFSuhCphhCopEhKpolA+HhSLW-ph...spsshpss-scallVlEDDNTlpc...lp..sl+shIpuMp-psIDlLQLREshpssssRs.hs.t.tp.shasYsGGYDhSLSAYIIRluoAh+lhspIhcptGlSsuLshElh+lEpcLtlNR.VLssuspYVpH-h+hlsc+Rss.ch+sulhsRlusWluppaPshhYhlopPLFSFFGlFDIsllGllhlLaIllLlIFslNSKLLWFLuGhhhoYll	...............................................chslhVlPll.sRssu-shPpl+p...h....pc.hcslKc.......hsp.tsh.h.pscsch.hsh.................................thl.Wpt.....Gslcs...asc.......aFSuhCsshCTcEsKpsIA+HhuLWcSh...h.s-hcspcscalVllEsDNslcc.....lphlcsllpsMp-ppIDIhQhREhhpssp.s+s.h.s.p.ts.thasYs.GGYDhSLSAYIIRlssshplhscIIKstGlSouh.hElh+lEpchplNR.llssus+YV.H-.+hlscpRhp.ph+sshWsRluphhu+paPshhYhhopPLlSFFGlFDIsllGlllILFIlhMl..IFslsS.KLLWFLsGhhhThhl..................................................................................	1	0	1	1
+3967	PF03395	Pox_P4A		Poxvirus P4A protein	Mifsud W	anon	Pfam-B_2985 (release 6.6)	Family	\N	25.00	25.00	49.40	49.30	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	888	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.75	0.70	-13.56	0.70	-7.01	4	92	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	46	0	0	84	0	847.60	67	98.38	CHANGED	QLEcSEYlF+llSTlLPplC...............LDYKV--tLppTFVHPFDslh.sshGsls+t-plpsulppLGINYLlsshsp..+LFshllssspIthhssshths......................................................................................................................................................................s+sNPllNsHoFs-LPsFTpcLlphRhps.Et+ARFhGGYlhsctus....................ssshs.h....cYPsLsF-NTYhhNlLYpssIss.ht..F+..................................................................................................................................A+sssGlhhhpDasNLlulRsLlospspsRF-psashpphApcaslsls.s.s.sclDLhoMso........................................................................................KphlhahQaFsDpYtch.hpaNGsslh.sc.clhslslSh+YQuhIs+Lspha.slPlhNshslhshstspsttphslsh.slpalslssNlsaFlshhN.......hlA+EpRs..ssLcs.p.ShFWDGlDYp-YKpKplp-hhFIsuoCYVFuLap+NsTTaCShLoDhluAspTP.RVCllPRsluu.+TsscLluEsLcSlNshoh+-FP+pssStl.HIGLSEpGFMRFFQLLRLlss+s.EoAlKEVlhsYsGlKhuDpGsPah.I+p-SYpsFlhLLFuuMGF+VoV+pSlhGSsNhohIolRP.RVo+pYIsshLhKsSCS+s-A-KLlousa-LLsFMlSsush+DhpSYh.tRphssshaauG....s.ps--..tTIIphopPlslLDRlslpGlhuAsTlsEhLssDhFtPENthFKsNLpthIpSsploG..-sIhptMPhslLD+llTs.......AGssp.VSls-llDNIss.o.DCDtTN-IsDhINouLKcohsKcNshlsSpshsuVANpScppLtDl+pS.oC+hAslFKsLA+SIYTlERIFNs+lSD-VKh-hLEKhKsFosISpSLYsD.......LIulEslKAlLYIlKRSG+sl-cTpIssD...-l+KSYplI+PKIhshhNYYsphSRsYFppMKKNLNMpDsstsS	.....QLEDSEYLFRIVSTVLPHLC................LDYKVCDpLKTTFVHPFDlLLNNSLGSVTKQDEL.QAAISKLGINYLIDTTS.pELKLFNV.sLNAGNIDlINssINIS........................................................................................................................................................................SETNPIINTHSFYDLPPFTQaLLNIRLTDTEYRARFIGGYlKPDGSDo...................MDVLAEK....KYPDLNFDNTYLFNILYKDV.IsuP..I.cp.FK..............................................................................................................................................AKIVNGVLoRpDFDNLIGVRQYlTsp.DpsRFDssYsIsDAApHYGVNLN..TLPLPNVDLTTMPT.......................................................................................YKHLIMacQYFlss.........Y-+VsIYYNGN+hlasD.EIhsFsISMRYQSLIPRLV-.hFPDIsVNNNIVL+TRD.PQN.AsVNV.sV.sLPNhQ..FVDIs+NpKFFINFhN.........LLAKEQ.RS..TAIKV.sKSMFWDGhDYEEYKSKsLQDMMFINSTCYVFGL.YNHNNTTYCSILSDIISAEKTPIRVCLLPRVVGG.KTVTsLISETLKSISSMTIREFPRKDKS..IMHIGLSETGFMRFFQLLRLMADKPHETAIKEVVMAYVGIK.LGDKGSPYY.IRKESYQDFIYLLFASMGFKVTTRRSIMGSNNISIISIRP.RVTKQYIloTLMKoSCSKNEAEKLITSAFDLLNFMVSVSDFR...DYQSYR....Q....Y....R..........N..Y.......CPR...YF.YAGS...P.............................EGEETIICcSEPISILDRIDTRGIFSAaTINEMMDTDIFSPENKAFKNNLS+FIES.GD.ITG..EDIhCAMPYNILDRIITN........AGTCT.VSIGDM.LDNITsQS.D.CN.MTNEITDMINASLKNTISKDNNMLVSQALsSVAN+SKQp.IGDLRQS.SCKMALLFKNLATSIYTIERIFNAKVuDDVKAShLEKYKlFTDISMSLYKD.......LIAMENLKA...MLYIIRRSGC+IDDA.QITTD...DLVKSYSLIRPKILSMINYYNEMSRGYFEHMKKNLNMTDGDSl.......	0	0	0	0
+3968	PF03292	Pox_P4B		Poxvirus P4B major core protein	Mifsud W	anon	Pfam-B_4215 (release 6.5)	Family	\N	25.00	25.00	27.30	25.20	17.20	17.00	hmmbuild  -o /dev/null HMM SEED	666	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.24	0.70	-13.22	0.70	-6.58	9	314	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	152	0	0	187	3	273.70	52	97.52	CHANGED	MEoshs......lFlsu+lsLtssYsNphL.LlspsHlHtPspSlSCSlCsSLuplss.--hISAGARppR.sl+R...........R...stspsst....p.ss+psss.h........shVPIDEluSTpDWpl+LR+DGsAIA+YLpssKsDlpNFTIQDhlslM+KLNIhRosRsELFELLuHVKuoLosoSlSVKsTHPLVLIau+ucP+IG-QhKEL-+lYSsSpYphLLSTTRFQShHFsDMSSSuDLhFca+ssDSshFlHPIhhALFGlKLPALENsFVaGDSYSLLpQLach+KV+P-NYMLLVNRLTE-uPIlhTGVsDslSTEIQRAslHTMIRKhIhNlRMGIFYCp---ulDsaLMKIIHssCSplMoDEEQhLASILSIVGF+PsLVSVs+Puhussa....DMpLQoVPYIVVsPhKMITTSssPISINosslaSLTaDutoGRVlFsPsshuYtttsssssssshssh...sssshtpshsSPVIVNGsLlFYVERRQsKNhhuGECYTGaRSlIsDpPI-Vup-lslNGIMYRL+SAVCYKlGD...phh.ssCs.....uuDIFLKGaYTILFTEhGPWhYDPLSlasKuuR-uRLhRAhKNpYt+ps..sthD-up.FY-WlKG-Gus.hhtuKQQ.LMNHhsMF-DDLLoMEEAMSLISRpCCILIYAQDY-PYloAKsIo-lF	.................................................................................................................................................................................................................................................t.............shlsIDElTSTHDWQhpLRKDusAIs+YLh-pKCDlpNF.ThQDLlpVM+pLNIIRs-RpELFELLuHVKuoLossSV...SVKsoHPLhhIYu+scs+IG-QhK.L-shasPS.cYQsLlsTTRFQSspFsD..MSo.SS.DhLFcFK.cpD..Sh..halHPIlhA.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+3969	PF03296	Pox_polyA_pol		Poxvirus poly(A) polymerase nucleotidyltransferase domain	Mifsud W	anon	Pfam-B_4019 (release 6.5)	Domain	\N	19.50	19.50	19.90	19.50	19.30	18.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.85	0.71	-4.65	13	65	2012-10-02 22:47:23	2003-04-07 12:59:11	8	2	45	9	1	62	42	149.10	72	31.45	CHANGED	chsShcclAc...chLsShNVsshoc.cl..MGRHsVSsL....VssVNpLMEEYLRR....HNKsCICYGSYSLHLLNPcI+YGDIDILQTNuRsFLIsLAFLI+FITGpsVlLLKVPYLKNYhVL+DccssHIIDSFNIRQcTMpsIPKlLIDNIYIVDPs	.........N.lTSMEELARDMLNSMNVAlIDK..uKV..MGRHNVSSL....VKNVNKLMEEYLRR....HNKSCICYGSYSLYLIN..PNI+YGDIDILQTNSRTFLID..LAFLIKFITGsNIILSKIPYL+NYMVIKDENDNHIIDSFNIRQDTMNlVPKIaIDNIYIVDPT........	1	0	0	0
+3970	PF03294	Pox_Rap94		RNA polymerase-associated transcription specificity factor, Rap94	Mifsud W	anon	Pfam-B_4535 (release 6.5)	Family	\N	25.00	25.00	63.60	63.50	19.20	19.00	hmmbuild  -o /dev/null HMM SEED	795	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.67	0.70	-13.50	0.70	-6.59	10	107	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	53	0	0	84	0	595.20	68	99.97	CHANGED	M-oKESlLIEIIPKIKsYlh-sshssKSYsDFIScNKsIFllNLYNVusITEEDIRLLYsTIEQNhDlDDQTLlSIFSYIGYKFEQsl+EEIooSLthsEps.hTD-M.TaNhYsLFFNTLDMYlRQ+RINVLVND-ssuD......lsINY+..TSDLsSsF-sstEPEVREIPFNMK-hlsYVSKNlDQlRFSKKYLDFAYLCRHIGIPISK+KhNlRYlaLYclDGloIPIVI+DFLDVKYVYLcETGKsY+NsFSE-hNsSLhDWG+lIIPpL...KN++LYSYlFLSsYaL+DLF.-LIpp+-ssF+stcp.hctIpltEPtuW+c-VplEahPCEHQI+LtEAhKlDs-YFsKlNsFAsEYIYYEDGlAYC+ICGhNlPpFNlDAADVIKss..VIVoTaNKSIFLSEPYSYFVHSQRFIFNIIMSFDsIMKSQTWsMKYNINRLILNFLI-INu+RQcYEK+FusEI.K+GlFFLRLSANLFDIHsSSTELFYSuKhLNLNYIVlLVIlLNSSADFIlSYMsuKKKp........VsEooLKauISVIIYDFLlKT+ICEKsuLDTIs..LhT-VYhSIMPEELcsHapRIllEL+KLlSIpRocptPsYDV-s+h...Plssl..+FFsspslhsp.Mhshp.tch...pspslhpPs.hstsoc-shppF.cclThc--hKVLIRhNDTNAopLVhFsoHlKIEIE+KKlIIsLKs...................LFIsNsLKYYY..............SssuhYVFRFGDPFPFD--LIDppHVQaKlNsYNLLRaaLLPcSD.VFVYFucSLsR--LEYsFYhFLspYVNs.VppWIDENIo+IRELYhhNFNN	....M-oKEolLl-IIPKIKsYlhDsshssKSYsDFIupNKsIFllNLYNVssITE-DIRLLYhTIEQNhDssDpTLluIFSYIGYKFEpsl+E-hsoSL.hs-p..hTD-M.saNhYshFFsTLDhhlRQ++lslLVND-hp.GD......h.lsY+..sSDLsosFssph-Pcl+cIPFNMKshlsYlpKNlDQlRFSKKYLDFAYLCRHIGIPISK+KhNhRYlahYplDGloIPIlI+DFLDVKYVYLEpTsKhY+NsFuE-.Nsul.-WG+lIIPhl...Ks+tLYSYlFLSsaaLpshascLltpc-shFhthpp..hchItltEP.uWcccVplEhhPCEHQI+Lh-AhKlD.spYFsKlNsFspEaIYYEDGlAYCplCGhNlP.FNLDAuDVlKss..Vl.VsTaNKoIFLSEPYSYFlHSQRFIFNIIMSFDsIMKSQTWsMKYNINRLILNFLI-INS+RQcYEK+FusEI.K+GlFFLRLSANLF-.psSSTELFYsuKhLNLNYIVsLVIlLNSSADFIlSYMpSKpKp........VpEooLKYuISVlIY-FLlKT+IC-KusL-TIh..LhT-VYTSIMPEELclHapRIhlEL+KLlSIpRSthpPNYDVEspt.t...Phssl..+FFsspslhs+sM..ss...pph....hppp.IstPs..sp..octshppF.+c.lTsD-DlKlLIRhpD.TNAoKLVIFPoHLKIEIERKKlIIsLpo...................LalsNsLKYYY..............Sss.LYVFRFGDPhPF---LlDpEHVQaKINCYNlLRYcLLP-SD.VFVYFSsSLNRcsLEYuFYhFLupYVN..VppWIDENIo+I+ELYhINFNN......	0	0	0	0
+3971	PF03340	Pox_Rif		Poxvirus rifampicin resistance protein	Mifsud W	anon	Pfam-B_3377 (release 6.5)	Family	\N	25.40	25.40	27.90	86.10	19.80	25.30	hmmbuild  -o /dev/null HMM SEED	541	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.82	0.70	-6.44	11	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	11	0	61	2	518.40	71	98.91	CHANGED	hhsSlIss......--u...s+RpNVFusDsppPThYMP.QYIolsGlh...ssssssVls..aEIRDQYIsAhNpFlLoIsLPElKGlG+FuYlPYVGYKsIpcluls......SsNslIWEosGE-LFssshsscpA.phSGaSpELNDlSsGhoPNDsIK-ussVYlYl+TPFDs-..cTaSSLKL.u-oKlslslTFNPlSDlllhDusFsh-uF..l+-FVYssELSFlGYhV+slphKssYIEcs....RRsluQhNpsT..sslo-VaulTuLuVYlKP..aYG.h-N+FISYPGYsQTEccYIpuaV-RLL-DLlIVScs....hPcsF.P-su-lVEVPssGlVsIQ.DsDVhV+IDNVPsshslYaHTNlLlFGTR+NSssYNISKKFSsIsGsYScsTc+IhFoclpHolNIoDVSIPVulWsup+NlYsGDNRSspSKsKDlalNDPFlKGlDFhNK.hDlISRhEVRFGN-llYSEsuPIS+IaNpLLossssusRpL...........pFNasPtsFF+PTsLhANsSRGKDKLuVRVsapshDssNPIpYVsKQLVllCsDLY+loYDss.IplsKIs-	.................lINSLIGu......DDu...IKRuNVFuVDsQhPTLYMP.QYIoLoGVho....NsusDspslu.oFEIRDQYITALNHLVLSlELPEVKGhGRFGYVPYVGYKCIpHVSlS......SsNGlIWElpGEELYNsCl.NNshALcpSGYSpELNDIShGLTPNDTIKEsoTVYVYIKTPFDVE..cTFSSLKL.SDSKITVTVTFNPVSDIlIRDSoFDaEoF...sKEFV.YVsELSFIGYMV...KNlQlKPSFIE+P....RRVlGQINQsT..AslTEVHAsTSLSVYsKP..YYGNTDNKFISYPGYuQsE+DYIsAaVpRLL-DLVIVSDu........PPoGa.PESAEIVEVPpsGIV..SIQ.DsDVaVKIDNVP-sMSVYLHTNlLhFGTR.KNSFlYNISKKFSAITGTYS-ATKRhhFuHISHSINIhDsSIPVSLWTuQRNVYNGDNRSscSKAKDLFINDPFIKGIDFKNK.TDIISRLEVRFGNDVLYSENuPISRIYNELLopsssGTRTL...........pFNFTP+hFF+PTT.IsANVSRGKDKLSVRVVYSoMDsNpPIYYVpKQLVVVCNDLYKVSYDpG.VslTKIh.G......	0	0	0	0
+3972	PF03293	Pox_RNA_pol		Poxvirus DNA-directed RNA polymerase, 18 kD subunit	Mifsud W	anon	Pfam-B_4188 (release 6.5)	Family	\N	25.00	25.00	259.40	259.30	22.30	21.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.82	0.71	-4.73	10	55	2009-09-11 05:39:38	2003-04-07 12:59:11	9	1	41	0	0	36	0	160.00	73	97.25	CHANGED	MSTFsppVYLPVsLpPHELTLDl+cNI+cAVh+cYLHKEouGlMAKKI-IChDpELPLGEIVNNpVVV+VPClVTYKYYKlGDlVpGTLNIEDESNIoVtCGDLICKLsRDSGTVSFsDSKYCFIRNGpVY-NGSpVSVsLKEAQpGh.-SsFVFLAoIlD	MSoFVsNsYLPVTLcPHELTLDIKsNIRsAVYKsYLHREhoGhMAKKIEIpcDsELPLGEIVNNuVVIsVPCllTYtYY+VGDIVRGTLNIEDESNVTIQCGDLICKLSRDSGTVSFSDSKYCFhRNGsAYDNGSEVoAVLhEAQQGh.ESuFVFLAsIVD..	0	0	0	0
+3973	PF03396	Pox_RNA_pol_35		Poxvirus DNA-directed RNA polymerase, 35 kD subunit	Mifsud W	anon	Pfam-B_3921 (release 6.6)	Family	\N	25.00	25.00	92.40	92.30	19.60	18.40	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.80	0.70	-5.38	11	79	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	48	0	0	66	0	275.80	64	95.56	CHANGED	RcEpplsl-LsPulATFIKHGFNp+V+WPlLslGVVLsNTTTAVNEEWLTAlEahPTRKIFYsaspcILcpElsFCVYLpKo.QopscsYloLtDFDYYlIcsDs.php+l-KPKELcETLLHoFQEYR..hKNhQsIELlAFSSGTpIs--llppLo.FLslElFNREYsNlKsllsppFcohsPFIVlAPhG+LTFFlEcYsWhDhKoHlK-lLDaLEtsLluDl+SHplpss..hpD.s.ssSuYNssSGhLaVNDllTMslVNFFGCsuRLsoYH+FDhoplDscsFl+ALucAh	..REEsoIsV-L-PuLATFIKpGFNshV+WPLLNIGlVLoNToTAVNEEWLTAVEHlPThKIFYKHlaKILsREhGFhVYLK+S.QSEcDNYITLYDFDYYIIDpDs.olohVDKPsELKETLLHsFQEYR..lKSsQoIELIAFSSGTlIsEDIVs+LT.FLDlElFNREYNNVKsIlcs-FlupuPFIVIuPhGKLTFFlEsYSWhDFKSphKDIlDFLEGsLlAsIHsHhIcVu..ssD..ETVSSYNPpSGhLFVNDLhTMsIVNFFGCNSRL-SYHRFDMTKlDlEhFlKALS-Ah.	0	0	0	0
+3974	PF04490	Pox_T4_C		Poxvirus T4 protein, C terminus	Kerrison ND	anon	DOMO:DM04331;	Family	This family of poxvirus proteins are thought to be retained in the endoplasmic reticulum.  M-T4 of myxoma virus (Swiss:O55698) is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection [1].	25.00	25.00	49.20	49.10	24.80	18.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.99	0.71	-4.45	6	35	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	17	0	0	33	0	141.70	45	64.07	CHANGED	sppsFIlsslccuVYusGHhsYhEhSs.Nlshl-slPpCu+pIoluVSCDp.ssshp.atcppphpcs-lpIslphDoSCl+ahShshSlps.Cp++Louhup........-pLsCstlcsppHs+YLKoCssspFDR.haKpYh.HQ+salsKlhh	.pspsFIlssscpshaGssH.sYlEhSs.Nsus.-slPcCS+plplSV.CDQ.suslc.apchpphcssslpIslKhDoSCIcaluhshShhNECp++Looh.p........-pLoCsuhchps+sKYLKTCossKFDRpsaKpYh.+p+shhsKs..L....	0	0	0	0
+3975	PF04491	Pox_T4_N		Poxvirus T4 protein, N terminus	Kerrison ND	anon	DOMO:DM04331;	Family	This family of poxvirus proteins are thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C terminal region (Pfam:PF04490).  M-T4 of myxoma virus (Swiss:O55698) is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection [1].	25.00	25.00	28.90	31.10	18.80	17.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.27	0.72	-4.13	5	44	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	24	0	0	36	0	46.50	59	24.35	CHANGED	TWclcIGLCIps.cDF+up+TGC..+hspGPGGLITEGNGFRIFsHD-C	.TWtLKIGLCIhA.KDFYscRTDCSVHhssuuGGLITEGNGFRllhHDpC..	0	0	0	0
+3976	PF03295	Pox_TAA1		Poxvirus trans-activator protein A1 C-terminal	Mifsud W	anon	Pfam-B_4259 (release 6.5)	Family	\N	20.70	20.70	21.10	93.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.95	0.72	-4.32	10	57	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	41	0	0	35	0	62.90	71	41.95	CHANGED	uMIKopVALREEPKloLLPLVhYccPEcVlslINsLRsKEGlYGoCaacEccpsIcloLRSLl	.SMVKSHVALREEPKISLLPLVFYED.EKVINsINhLR-KDGVYGSCYaKENuQhIcISLRSLL	0	0	0	0
+3977	PF03355	Pox_TAP		Viral Trans-Activator Protein 	Finn RD	anon	Pfam-B_3956 (release 6.5)	Family	These proteins function as a trans-activator of viral late  genes.	25.00	25.00	245.00	244.90	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.84	0.70	-5.02	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	42	0	0	35	0	253.90	80	99.79	CHANGED	MSLRIKIDKLRQIVTYFSEFSEEVSlNVDsuSslMYIFAoLGGSVNIWoIVPLsSNVFYDG-sNpVFNLPVLKVKuCLCSFHNDAVVoIEPDl-NssV+LSSaHlVSVDCNcEslPHRTsTuISLGIsQKKSYIFNF+KYEEKCCGRTVlHLDLLLGFIKCISQYQYLTVsFc.DKNLlLKTPGo+DTFVRcYSMTEWSP-LQsYSFKIAIsSLNKLRGFKKRVlVFEoKIVMDsDDNILGMLFRDRlGoY+VNVFMuFQD	MSlRIKIDKLRQIVAYFSEFSEEVSINVDSsDpLMYIFAALGGSVNIWAIlPLSASVFYcGs-NhVFNLPVSKVKSCLCSFHNDAII-IEPDLENNLVKLSSYHVVSVDCNKELMPIRTDToICLuIDQKKSYVFNFHKYEEKCCGRTVIHLEhLLGFIKCISQaQHLsIhFK.DDNIIhKTPGNpDsFSREYSMTECSQELQKFSFKIAISSLNKLRGFKKRVNVFETRIVMDsDDNILGMLFSDRlQSFKINIFMAF.D.	0	0	0	0
+3978	PF04441	Pox_VERT_large		Poxvirus early transcription factor (VETF), large subunit 	Finn RD	anon	Pfam-B_3920 (release 7.5)	Family	The poxvirus early transcription factor (VETF), in addition to  the viral RNA polymerase, is required for efficient transcription of early genes in vitro. VETF is a heterodimeric protein that binds  specifically to early gene promoters. The heterodimer is comprised of an 82 kDa (this family) subunit and a 70 kDa subunit. 	25.00	25.00	242.20	242.00	16.70	16.70	hmmbuild  -o /dev/null HMM SEED	700	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.39	0.70	-6.37	9	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	0	0	60	2	696.20	72	98.19	CHANGED	hYhVsPQLVlLVs+sQcIc+sLYLohYshID-p..SslY.YFl+saLch..ppPcll+RHILLTL+lpQlKGYlpsLLslp-DIIIYSHKNNLEYSYVDNTIFNPFs.TQ+KTLI+sD...uFLYNlYssACDFLVlWVApAs..DTslsEhGSY........EEVDsNILKFEp+LlpsFspLDL-holpSKFNNIFRTNL+.TGL+sIlpp.....p...sh+hLlh+oDEaFIshoGN+FlLsD.......EpLNLSIWDssssLAISSDGcTlhlNsVcLFT-lls-.slQMERIKu...DlTYKlaLsTPITS+lKLDIETSFIFlET.ATNNILLSsDKKISIILAKNHISIKVKNaIPNIEKYFTFLllulNphFNsVQpSuDFTKlETlYWSRICQNTKsKNRKPVIlsSLDss.MpKlSDNFY+Scp+....................EVFlNsNGlMFoChDPhG+YNslGFLuIFY+Lp+..hCIPCCFL+sQuHo-TFpSCVapc-.lpcshlsPYILNFGKlV.TpSKlSFLPIlFssahNcshpIshEpDNKRL+tTsGYaVV+uCpss....IhRlRThsDIIpFVNpsssILIssDhVYFPM....sh.chsN...+laILIQEIVHElVhl+KptcpDtIthh.ssps+...L+-hFPhposphsItp-sGlsLTTDGFalDGchFspcLSopassFhcNlospsts.uKYFu.lFKYVl.....T-sh-hFIKTWlINIMlphGhssp.st..hhstLEKYYsp	R.YIVSPQLVL.VGKGQElERALYLTPYDhIDEK..SPIY.YFL+SHLNI..ppPEIVKRHILLTLRMoQLKGYLGNLLDI+DDIIIYSHKNNLEYSYVDNTIFNPFVaTQKKTLlKsD...SFLYNVYPGACDFLVIWVARAs..DTSIPEFGSY........EDVDNNIlKFEThLhEVFPpLDLDhTVESKFNNIFRTNLKhTGLKKIIQ+Vp..-LDl.NYKSLLS+hDEaFINMTGNHFILND.......EpLNLSIWDhDGTLAlSSDGDTlMINNVKLFTDLV.SDIDTQMERIKG...DITYKVaLuTPIsSRIKLDIETSFIFIET.ATNNILLSoDKKISIILAKNHISIKVKNHIPNIEKYFTFLVIAINuMFNSVQKSuDFTKVETVYWSRICQNTKNKNRKPlIIs.LDss.MKKISNNFY+SDcK....................EVFINDNGIMFTCMDPLGKYNpVGFLNIFHchpK..hCIPCCFL+DQSHcsTFSSCVHQhD.V-KcIlSPYILNFGKVV.TESKhSFLPIIFDsFLNDGMoAshEQDNKRLKETSGYHlVRCCsG-....sIVRLRTsSDIIQFVNEDKNILIsNDMVYFPM....NsoDIGp...KIHILIQEIVHEVhIVKK+EooD+IDFFPPNYKL...LKDLFPKQThpssIpSDuGMsLTTDGFYIDGKLFN-DLSSKYVTFTKNVhsS..DuV.uKYFSPLFKYVI.....oEAKDRFIKTWhINIMl+MsVDPss....IIPsLEKYYPN.	0	0	0	0
+3979	PF04947	Pox_VLTF3		Poxvirus Late Transcription Factor VLTF3 like 	Finn RD, Iyer L	anon	Iyer L	Family	Members of this family are approximately 26 KDa, and are involved in trans-activator of late transcription [1].	25.00	25.00	35.80	35.50	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.96	0.71	-4.75	23	135	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	120	0	1	101	263	169.80	31	59.54	CHANGED	pthppssphs...hs+h.Ha+ssLpphQu+pssp........lsscllcplccclccpplp....................hsclspshVtpaLKcLs...h.sKpYcsshhIhphlTups...ssplspch-pplhchFcplhphapc..............tpcpshlsYsalLa+lhchh.....uhsppLssh.hlKstsKhpspD..placclhscLsWcahtt	........................p..pcsshas.s+h.Hh+psLc+h.u+p...........hss-llspLhchhcKppIs..................hs-lstshVpshLKthc...h..pKtYchVh.Ihsplpscc.....slosch.pclhclFcclhhhhpc.................ss.pphlsYSahL.Klh-lh.....uhscpLps..plKshsKtsspp..hlWcphhschphchh..p....	0	1	1	1
+3980	PF04498	Pox_VP8_L4R		Poxvirus nucleic acid binding protein VP8/L4R	Kerrison ND	anon	DOMO:DM04340;	Family	The 25 kDa product of Vaccinia virus gene L4R is also known as VP8.  VP8 is found in the cores of Vaccinia virions and is essential for the formation of transcriptionally competent viral particles.  It binds both single stranded and double stranded DNA and RNA with similar affinities.  Binding is thought to involve cooperative interactions between protein subunits. The protein is proteolytically cleaved during viral assembly at an Ala-Gly-Ala site. Possible roles for VP8 include packaging and maintaining the DNA genome in a transcribable configuration; binding ssDNA during transcription initiation; and cooperation with I8R protein to unwind early promoter regions.  VP8 may also function in either transcription elongation or release of mRNA molecules from viral particles [1].	25.00	25.00	26.10	174.20	20.80	19.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.34	0.70	-5.03	8	58	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	43	0	216.10	66	86.45	CHANGED	AKlKFPRShLSIaplVPRsMTRYELcLlpoEsITGsVFTTsYNl+KNLGls-.-KLThpsIEcYYLD.sN-VLTLMlsNTslscl..us.R++uRR.pKNPVlFRpGSsPLlllFcSRKKlsIY+Ecpcpss.sooYspIssslALls+YushpLLDVHoPSusLpLsAVYGh.sscpEL+KLuosKElEsYQsos.LpEPl+LsDFppLF-slKKsIsLTNlsh	AKsKFPRShLSIFNIVPRTMoKYELELlpsENITGAhFTThYNIRpNLGLGD.-KLTIEAIENYFLDPNNEVhsLlINNTDhouV...lPKKuGRR.NKN.VIFRQGSoPlLhIFEoRKKlNIYKENh-SA..sopYo.IGDNhALISKYAGlslLsVaSPSoSM+LNAlYGF.TsKNcLcKLSoNKELEsYSSoP.LQEPIRLNDFlGLh-CVKKNIPLTsIP.s	0	0	0	0
+3981	PF04395	Poxvirus_B22R		Poxvirus B22R protein	Mifsud W	anon	Pfam-B_3510 (release 7.3)	Family	This is highly conserved C-rich, central region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses. There are three pairs of conserved cysteine residues.	25.00	25.00	42.70	42.30	22.10	16.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.82	0.71	-11.44	0.71	-4.81	14	108	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	32	0	0	94	0	176.60	39	11.78	CHANGED	hssC-ssShphMspssulPcpFNsTLpphulpssssops..aYtC.hl.psss-C....uls.hhsssohpslsp..pppsppppRcpco....hpshpp-DhhChaptYshsppts-.......Csssp....................cppppccpscss.ssp.sclshhutccLGs..+shIPpcssclQlGspG.t-us....VsGDssIYppVKpchcptlpshhssss.....ssshPp	.............husCc.csSM..sLMsuVlssspEFNsTLcpl.G.lpsspssss...YYtC.hl.sssusC.phlsLsphlsshThssl.p...sshsssssR+pRs...................hp..ssc-lpClYcsYGlscp..sc.......C........................................hpps+ccp.scst.........pthcLhppupc-Lth..csVIP+uTT+hQVGupG.ssGs....VsGDss.apsVKschp.hhcchhPpls....hsh...cp........	0	0	0	0
+3982	PF00550	PP-binding	pp-binding; 	Phosphopantetheine attachment site	Bateman A	anon	SCOP	Domain	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-3.71	163	41592	2012-10-02 01:16:24	2003-04-07 12:59:11	20	3219	5404	127	13580	37590	2935	66.40	23	7.49	CHANGED	ptltp.hlsphl..t......t.ppl...sss.ssh....h.c.hGh.DSlthhplhsplpcp.h......h..plshs..plh.p.tsolpplsphl	........................................ltp.lhsclL.......s........h..ppl............shc..ssF..............h..-..LG...s..DSLtslclhs..p.l........c..cp..h..............u..l.........pl.ssp............plh...p...hs.....Tltslsth.........................................	0	3350	7619	11106
+3983	PF02503	PP_kinase		Polyphosphate kinase middle domain	Mian N, Bateman A	anon	Pfam-B_2701 (release 5.4)	Domain	Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.	25.00	25.00	27.60	26.70	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.22	0.70	-11.20	0.70	-4.82	173	3692	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	2906	6	697	2965	1012	200.80	31	31.95	CHANGED	pppppalcpaFpcplhPlLTPlulDsuHPF.PhlsNtoLslslpL..c..............s......s..................................................t........pt..h.AhlplP..psl.PRhl..pLP........ttts...................alhLEslIptalspLFsGh...clhssh.FRlTRsuDlpl-.p..--.sc.DLlptlcppL+.pR+hG..psVRLElsss.hspplhchLhc..........plplsc.p-lapl.sG..lsLspLhplss.hs...pscLcas.sasPt.hs..ttl	.............................................................................tpppalcpaFpcplhPllTPlul..D.s.s.HPF..PhlhsculslAVpl..p....p.........tps...................................................t..........................p.....tp..h.AllplP...psl..PRhlpLP.............................schs.t.th..........................alhL-sllpt..alccL...Fs..Gh...clhssapFRlTRsuDlpl-..p....--...s..c...sLhptlpppL.ppR+h.G..psVRLE....l.pps..........h.sp....t....h....h.c..hLhp..........chs.lsc.pDlahs.sG...lsLscLhplss.ls......+scLph..PasPhh....h....................	0	208	457	598
+3984	PF03012	PP_M1		Phosphoprotein	Griffiths-Jones SR	anon	Pfam-B_1336 (release 6.4)	Family	This family includes the M1 phosphoprotein non-structural RNA polymerase alpha subunit, which is thought to be a  component of the active polymerase, and may be involved in template binding.	20.60	20.60	21.50	21.50	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.94	0.70	-5.06	11	932	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	30	6	0	723	0	217.20	76	99.90	CHANGED	MSKIFVNPSAIRAGLADLEMAEETVDLVN+NlEDsQAHLQGEPI-VDuLPEDhp+LpIsDspssphsspssppEtup-EDFYhsEupDPhlPFQSaLDslGhQIVR+MKTGEtFFKIWSQusE-IlSYVssNF.PtPssKsoc-KSTQTssccsppssptosssp+-cpSspsshsup.-sSGPsuL-WusoN--D-uSlEAEIAHQIAESFSKKYKFPSRSSGIFLWNFEQLKMNLDDIV+pA+slPGVsRlAc-GsKLPLRCILGaVA.spSKRFQLLVsoDKLuKlMQDDLN+Yhup	.......................................HLQGEPIEVDsLPEDM+RLpLDDtKPSsLGEhA+sGEuKhcEDFQMDEGEDPuLLFQSYLDNVGVQIVRQMRSGERFLKIWSQTVEEIISYVsVNF.PssPG+SSEDKuTQTssRElKKET.hsuso.QR-SQsSKA+MsAQ.oASGPPALEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLK.....................................................................	1	0	0	0
+3985	PF02818	PPAK		PPAK motif	Bateman A	anon	M Greaser	Motif	These motifs are found in the PEVK region of titin.	21.00	21.00	22.80	21.00	18.10	20.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.44	0.72	-4.04	33	559	2009-01-15 18:05:59	2003-04-07 12:59:11	10	58	28	0	180	495	0	27.60	59	1.68	CHANGED	PPsKVPEsPKKsVsEEKlslslPKK.Es	........PPAKVPEVPKKsVPEEKlslslPKKsEs...	0	15	15	26
+3986	PF01326	PPDK_N	PPDK_N_term; 	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	Finn RD, Bateman A	anon	Sarah Teichmann	Family	This enzyme catalyses the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).	20.00	20.00	20.10	20.10	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.06	0.70	-5.40	101	5203	2009-01-15 18:05:59	2003-04-07 12:59:11	14	40	3545	11	1535	4567	2865	323.40	27	40.31	CHANGED	tsssth..h.GGKussLucht.............ptGl.sVPsGFslos.ss..apthh................st..l.t.l.th.t.....................ts.tthtthsttlpphlhp.sthP...spltpt...ltps..........hpp..hht.........................s.lAVR......SS.......................AssEDhsps..SFAGphcoh..Lslpu............cplhpul+psauShass+AhtYR........tpps.hst.............tpsthAVlVQpMltu........p..soGVhFTtsP..........hsu.ppst.hhlpushG.LGEslVuGps.ssDpahl..pp.th..........................stp.h.hh.........................................tttpt...sLs-...............................pp.....ltpLsph........upclEpt..aGt......P..D..IEWAlss.......sp...lalLQuRPloshtptsttt.tht.......................lpst	.................................................................................................................hp...th...l.GGKsAsLuEMh.................................................thGl.s...VP.s.G.FslTs.cu..hpp..ah....pp........................................................st.....l.p.p.l.hphhp....................................................l.ls..s..hs..th.t.t..s.hsthhp.hlls..hshs........sch...ps........ltpt..............hsp...hhs............................................sshs.lR..........oS.......................................................usuED..h.pt.........uh.AG.p.coh........lslps.......................................................h-pl..htAlctVauShhssRAlsYR..............htps..hsc..................................p.huhuVsVQp....MVhu.........................s....uoGVhFT.hss..........toG.tp..p..h......s.......h...hs.G..GE...sVV.s.Ghh...sP.cp...hh.h...t............................................................................................................................................tph......slps............................................................................................................................................................pt....hpcLs.chutplEpH....Y.tc........................s...DIEash-s............................Gc......LallQsRst...ppstttt.................p...................................................................................................................................	1	586	1082	1362
+3987	PF01239	PPTA		Protein prenyltransferase alpha subunit repeat	Finn RD, Bateman A	anon	Prosite	Repeat	Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognise a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognises a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family [2].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.44	0.73	-7.42	0.73	-4.39	143	2973	2009-09-11 15:11:22	2003-04-07 12:59:11	17	39	322	678	1957	2958	11	30.30	27	27.00	CHANGED	cELphspphlptsscN.assWpaRphllppht	..........pELphspphl..pp..sscN.a.ssWpaRphllpp...........	0	614	1031	1549
+3988	PF02541	Ppx-GppA		Ppx/GppA phosphatase family	Mian N, Bateman A	anon	COGs	Family	This family consists of the N-terminal region of exopolyphosphatase (Ppx) EC:3.6.1.11 and guanosine pentaphosphate phospho-hydrolase (GppA) EC:3.6.1.40.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.61	0.70	-5.22	10	5020	2012-10-02 23:34:14	2003-04-07 12:59:11	11	15	3248	19	1263	3783	1832	281.70	27	64.20	CHANGED	llschssGt....hphls+pKppV+Lu-u.hspss....hLsp-uhpRslssLpcFsElhpsass..pplpsVATuAlRcAhNu--Fls+lp+thG.....hsl-lIoGp-EARlsahGVspsh..scuctlVlDIGGGSTEllhGps.....tcsptlhSLslGsVplscpahscD..slspcphpth+chlcph..LpchssphchtG....htpslGsssThcsltplpssps.........ttpITtcclpphlcclhphsp.....cchcltGlsp-RAsllsuGslIlpulhctLphc.slplSssuLREGllhuhlhpc	.............................................................................t...stt......h.p.hl.s.ph.+p..hVRLupG...lspss...............tLsp-uhp.R.....u.hpsL.p.hFsch.h..p.....s.h..s.s......pp..l..p..sVA.Tu.slR..p..AtNu.s..-Flpcspc.hh.G.........h.sl.....cl.IoGpEEA+..Lh.a............h...G............l.......t.......p.....s.....h...............s.........p..........s..........c..............h........L.....V..l.D.....IGGGSTE..ll.hup.s.................................tp.stt....h...h...S.h..s..h.GsVp..h...t.....c.p...a.......h.....s.....s...s..............hs...p..c.p....h...p...t...h....pt........t...sppt..............l.p...s.....h...s....t.....p....h.ph.ts......................h.hs.l...G.....s...u..s.T....l.p.....s.....l...t.p.l...h...h..t..h.s.........................................sttlo.hpclpp....lhp...cl.h...p.hst...............hpc..h.p.l...G...l..s.t-R.tsl..lsuGhslltsl...hctl.....s...h.........p...p......h......tlu.ss.uLREGllhphh...h...........................................................................................................................................................................	0	378	804	1077
+3989	PF04403	PqiA		Paraquat-inducible protein A	Kerrison ND, Finn RD	anon	COG2995	Family	Paraquat is a superoxide radical-generating agent.  The promoter for the  pqiA gene is also inducible by other known superoxide generators [1]. This is predicted to be a family of integral membrane proteins, possibly  located in the inner membrane. This family is related to NADH dehydrogenase subunit 2 (Pfam:PF00361).	21.50	21.50	21.60	21.50	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.76	0.71	-4.66	167	3875	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	1245	0	618	2356	195	157.40	30	72.64	CHANGED	ulpcs.hAlhluullhhlsANhhPlhp..hph...hGt.ppssTlhuGlhtLh.ppGthslAhllhhsSlllPhh+llslhhLhhsh..pht...............h.t..htpth.lh+hlchlscWSMlDlFllullluLlclss........luslpsGsuh...hsFuhllllohhushphDsRhlWcthp.t.pp	.................................................lppshAhh.ls.ulllhl.ANl..hPlhh..........hpl.............hGs...p.psT..lhsGlh.L.h.pp...u...s...h.sl.As..llFlsolhlPhhpllslhh...Lhhss...c.ht.h...........................h.shppp......lhchl.ph.ltcWuMlD............l.F.............l.lulhluhl+..hts...................................hhs.ltsG.su.h...hhFshhllLThhus.phDsRhlW-ph....t.....................................................	0	132	279	449
+3990	PF01502	PRA-CH		Phosphoribosyl-AMP cyclohydrolase	Bateman A	anon	Pfam-B_782 (release 4.0)	Family	This enzyme catalyses the third step in the histidine biosynthetic pathway. It requires Zn ions for activity.	21.50	21.50	23.60	23.40	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.57	0.72	-4.35	168	3692	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	3587	2	1007	2642	1827	75.10	51	36.77	CHANGED	MlAaMNcEAlppTlpTGpspaaSRSR.pcLWpKGETSGphQpVp.clphDCDsDslLltVct......tGs..A.CHT......G.pcSCFap	............MluaMNpEALp+TlcoGc.ssaaSRSR.pcLWpKGETSGphQpVh.s......lphDCD.sDoLLlhVp...........hGs....s.CHT.......G.ppSCFh.t.............	0	326	664	868
+3991	PF01503	PRA-PH		Phosphoribosyl-ATP pyrophosphohydrolase	Bateman A	anon	Pfam-B_784 (release 4.0)	Family	This enzyme catalyses the second step in the histidine biosynthetic pathway.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.62	0.72	-3.70	53	4463	2012-10-01 21:36:44	2003-04-07 12:59:11	12	19	3909	57	1077	3829	3398	91.00	30	42.54	CHANGED	lpchccshttcttp.tPps..stphhsh........ptphlt.......EEh.sEhht.............Asp....ps.................................shsclsctlsDl.......lYhshGthsthG.......................l..c.hcslhcplccuN	.......................................................................h..phtphltp.Rpps....pPpsS...aTspLhscG...........pplspK.lG..............E..Eu...sEssl...............AAp.......st............................................................................................s.cp..c.lssEsuDL.......lY..Hh..h...V...hl.t..p.tG...........................................................................................l.....s.hpclhppLppp...................................................................	0	327	690	914
+3992	PF03208	PRA1		PRA1 family protein	Mifsud W, Bateman A	anon	Pfam-B_2976 (release 6.5) & Pfam-B_8147 (Release 8.0)	Family	This family includes the PRA1 (Prenylated rab acceptor) protein which is a Rab guanine dissociation inhibitor (GDI) displacement factor [2].  This family also includes the glutamate transporter EAAC1 interacting protein GTRAP3-18 [3].	21.30	21.30	22.10	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.99	0.71	-4.88	58	779	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	305	0	497	744	4	144.50	22	68.28	CHANGED	phptthus..hRPW.s-Fh.-hsphupP..pshu-htsRlppNLsYFpsNYhhlshhlhhhsLlh.pPhsLllh..hslhsuhhhlahhps................pslslhs+phsspphhh.................slhlsolh.llal..sus..ssslhhslshuhhllhhHAuhRt.sp.....h.ht-pcstths	.................................h...thsshRsh.s-Fh...s..........p....phuhP..pshschpsRltpNLtYapsN...Yhhlh.hhlhh..h.s.llh......pP........hhllsh..hhlhs..s...hhhlh..hhps.................pslhhh..t..p.phs.spt.hhh..................................slh.hsuhh...lhhh....su.s..hhslh.hslshshh.llhhHAuh+...p..................s........................................................	0	145	277	397
+3993	PF00697	PRAI		N-(5'phosphoribosyl)anthranilate (PRA) isomerase	Bateman A	anon	Pfam-B_247 (release 2.1)	Domain	\N	20.60	20.60	20.60	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.28	0.71	-4.76	23	3795	2012-10-03 05:58:16	2003-04-07 12:59:11	17	13	3604	9	968	2961	2133	193.90	32	66.13	CHANGED	s+hsulpphpDlhtshsssu....htuhlhssssp+phs.cpuptlhpsss.hh..lVGVFhNpslsplhphhpphuLDllQLHGsE..st-htphlt..lPll+ththstsht.....ht.sppt.p....shhLlD........utpGGoGpthDWshlpphht...........................hpllLAGGLsP-NVspAlp.......pshGlDVSSGVEos...Gl.KDhcKlptFlps	.................................................................................................................KlCGlop.p-spsAhpsGA.....shh.G.h..l..F...h.......p...S........R.............pV..........s.............h...c.p......A.......p...p............l...h...p...t.....h....s.....t......................hV.GVF..l..s........t...s...h......s.p.........l.h...c.....h..h.....p...p.h.s......L.shlQ.......L..H........G......s.......E..........s..t..ph.....h..........p.........t..........l....c...................t...........h....s........h.......h....p....s...lt..h...s..t..shp..................ht..h...p...p...h...tth...........DhhL.hDs............................................................sthGG.....oGpsF.D..Ws..l...l.ss.ht...h............................................................................................h.s.h.lLAG..GL...ss...-..N...ls..c..Alp.................hts....hulD..luSGVEss........Gh....KDhp+lpphhp.t........................................	0	323	632	826
+3994	PF03967	PRCH		Photosynthetic reaction centre, H-chain N-terminal region	Finn RD, Bateman A	anon	DOMO_DM03113	Family	The family corresponds the N-terminal cytoplasmic domain.	20.10	20.10	20.20	120.20	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.59	0.71	-4.58	21	85	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	78	111	27	89	105	137.20	45	53.31	CHANGED	Ms.sGshhuahDlAplslYsFW.lFFAuLlaYLppEs+REGYPLps-.ssustsspu......hhslPpPKTFcLtcG+.shslPsspp-....psclshsposshsGuPahPTGsP...hsDGVGPuuaA.RpDhP-lshcGps+IsPLRls	....M.tsshhuahDlAQlsLYsFW.lFFAGLlaYL+pEs+REGYPL-s-..ss....s....phtstG.....hhslPpPKTFhLsc.Gp.TholPsspss....ptsls..hptsushsGuPhhPTG.sP...MlDGVGPuuaAsRpDhP-Lsh.cGps+IVPLRl...	0	6	14	17
+3995	PF00432	Prenyltrans	prenyltrans; 	Prenyltransferase and squalene oxidase repeat	Bateman A, Finn RD	anon	Pfam-B_130 (release 1.0)	Repeat	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.07	0.72	-4.38	69	2497	2012-10-03 02:33:51	2003-04-07 12:59:11	16	40	482	411	1550	6750	154	43.70	26	14.26	CHANGED	hshcphhpalhppQp....-GGasspsss............pscsttohhulsuLslls	............................pplhpalhp.pQp.......sG.Ga.s.s.+.ssp.................................hsDs..ha..ohashsuLpll.............................	0	520	866	1268
+3996	PF01080	Presenilin		Presenilin	Finn RD, Bateman A	anon	Pfam-B_789 (release 3.0)	Family	Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease [2].  It has been found that presenilin-1 (Swiss:P49768) binds to beta-catenin in-vivo [4]. This family also contains SPE proteins from C.elegans.	24.50	24.50	24.50	24.70	24.00	24.40	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.44	0.70	-5.64	6	478	2012-10-02 13:41:03	2003-04-07 12:59:11	12	7	156	1	255	421	7	264.60	37	83.85	CHANGED	cEEtsLKYGApHVIhLFVPVoLCMllVVuTlpolpFYsppsu.pLlYTPFscpo.osup+hLsSlhNuLlhIuVlVlMThLLlVhYKa+hYKlIHuWLIlSSlhLLFlFohlYLpElh+sas.......lshshsTlhlhlhNFGslGMhsIHWKGPLRLQQhYLIhluALMALVFIKYLPEWTsWhlLssISlWDLVAVLsP+GPLRhLVETAQERNEslFPALIYSSs.hhhhVs........sss.t..posc.s..............................ssptps.........phsp.pps.ptpcDsusoptpp.....o...............ppsuhhhs....cphttph.-lps....s...p....pt..........pEERGlKLGLGDFIFYSVLlGKAuuo..GDWsTTIACFVAILIGLClTLlLLAla++ALPALPISIshGLIFYFuTchllpPFh-	................................................................................lh.PV.hs.Mh...h...s..h.h......h........................................................t..................................h.......h.h.............t...................t................th..t....uhhsshhhhshlhhhThhhlh.Lah.....hphhthlhsahhhushhll.hhh.sh.hh....lhptht.......hshD.h...oh.h..hhhhN.hu.slG.h.hs.l.a..h.t..s..sh...l....pQhYllhhuslhA..h.......hhphlP-...WosWhlLhhhulaDlhAVLsPhGPL+hLl-hAppRsc...PuLlYput......h....................................................................................................................................................................................................................................................................................................................................................................................................................................ttslKLGLGDFlFYSlLlu+....Au............sh.s.hhsshl.ullh.GLshTLhlLuh.h.p...c...sLPALPlSlhhuh.....hhhh.st.hh..................................................................................................................	0	93	133	193
+3997	PF03991	Prion_octapep	Prion_octopep;	Copper binding octapeptide repeat	Bateman A	anon	Bateman A	Repeat	This repeat is found at the amino terminus of prion proteins.  It has been shown to bind to copper.	12.10	0.50	13.10	0.50	11.80	0.40	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.22	0.75	-5.16	0.75	-2.73	5	127	2009-09-13 17:14:17	2003-04-07 12:59:11	7	9	13	0	5	130	0	7.80	94	27.84	CHANGED	PHGGGWGQ	..PHG.GGWGQ.	4	0	0	0
+3998	PF03063	Prismane		Prismane/CO dehydrogenase family	Griffiths-Jones SR, Bateman A	anon	Pfam-B_2956 (release 6.4)	Family	This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centres - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster.  The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested [1]. The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe [2].  The CO dehydrogenase contains a Ni-3Fe-2S-3O centre.	21.70	21.70	28.20	24.40	20.20	19.50	hmmbuild  -o /dev/null --hand HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.80	0.70	-6.13	251	2395	2009-09-15 11:55:15	2003-04-07 12:59:11	15	14	1486	49	664	2022	69	468.60	34	95.85	CHANGED	MaChQCpps....ts.suC.phs.................GVCGKss-sushpDlL.lhshpGluthupc.u+ch..........tspphhhpuhFsT.....................lTNssFcspphlphlpcshsl+...pph...............................................pshpphstpss.........phhlsthtpp..sp..DlpuLcphlhaGlKGhs.........AYtcH............AhhL.Gtt-c-.lhphhpcshssh..ss.csls......tllshslcsGths.hpsMtlLDpussttaGsP....ps..TpVslGlh.ps..ssIlloGHDlpshc.LLcQTcspGlslYTH.....GEhLPupsYPsh+..pYpH.......hsGsaGsuWppQpp-FsuhsusllhToNClhPs..h.p.sp...Y+s+laTTuslua...PG.spHI...p.............tpt.....t......................cDaotlIcpAlcshs.p.............c.............ps.p......lhs......GFu+psllshu..............c.......................tll-A.....................................................VKsGsI++hhlluGCDGt+ssRs..Yas-hAcpL.PpDsllLTsGCuKa+a...s+hsLGsl.........G.G...................IPRlLDhGQCNDuYuhlhlAhtL..AcsF......s.s.-lN-LPl.....uhsluW..aEQKAVslLLsLLsLGl+sl+LGPohPuFlSPsVhplLs-s....a..slss..hs.slEpDhpthh	..............................................................................................MaChQCp........ssuCpht.................GhCGKss-sushQDhL.lhshp..G.lu.sas..hc...uRcht.............................scphh.puhatT..................lTNsNFcs.phlth..h.tp.t.hthcpth.....................................................................................................tshtph..tpst.......ph...h..t..ttt...tt..shhslc.hhhhsh+sh...........ahcp............uhh.....sthc...........p-lh.t.....hpp....hh.s.hh..ss....shs..........llthshchGths.hpsMtlLDtupTtt..a....GpP.............ps...opVslt....sh.ts..hsIlloGHDLpslttLLcQ...o...c...u....p......G....l....slYTH......GEMLPupsYPth+..+apH..................hsGshGsuWtpQph.FsthsusIlhToNClhss..s.......YpsRlaTpu.suh......PG.s.p.H.l...p...............................t....................cDFs.lIppAhph.s.......t...t...hhhshshs....................................................slhuhActll-h......................................................................VppGpl++hhlluGCDuhpst+p....Yas-hAppl.PpDslILThuCuKa+a...s+.hshGsl..............s.G...................lPRllDhGQCNDuhuhhhlAhtL..uchh.............s.h..slN-LPl....shsluW...aEQKAlslLLs..LLtLGlpsIhhGPshPsFhosslhtl.Ls-p.......a.....sltsls..ss-pDhpth..............................	0	274	478	585
+3999	PF00484	Pro_CA		Carbonic anhydrase	Finn RD, Bateman A	anon	Prosite & Pfam-B_9319 (Release 8.0)	Domain	This family includes carbonic anhydrases as well as a family of non-functional homologues related to YbcF.	22.10	22.10	22.10	23.40	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.89	0.71	-4.22	497	5590	2009-01-15 18:05:59	2003-04-07 12:59:11	14	20	3442	146	1635	4073	995	149.00	28	64.39	CHANGED	slhluCuDSRls..sphlh.shtsG-lFVlRNsGNlls................................stss.huul-a.......AlphLpV.ccIlVhG....HssCGulp......su..........h.............................shlsp....hl....pthpsshpp.......htt..tt......................pph..........ph.............ctNVhpplppLppp..Phlp....pthtpup..........lplpGhhYclps......Gpl	...................................................lhluCuDSRls.....sphlh..s......h......t......s......G..-.lF.Vl..RN..suNlV...........................................................stsshu....ul.pa.....................AVp.....h.L.p..V.c.......cIlVhG....HssCGulp.......us........................................hp.........................s.................hshlpp..a.l..pp.h.p.ss.hhp.........hpph.h.tt..........................................s.pph....th......hc.sVhppltpLtpp..shlp..................t.t.h.t.c.sp.............................ltl+GhhYslpsGp.................................................................	0	480	1010	1381
+4000	PF01619	Pro_dh		Proline dehydrogenase	Bateman A	anon	Pfam-B_1092 (release 4.1)	Family	\N	27.00	27.00	27.10	27.00	23.80	24.20	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.91	0.70	-5.44	15	3379	2012-10-01 19:29:00	2003-04-07 12:59:11	13	21	2877	20	991	2741	1035	291.10	31	35.23	CHANGED	lsG-sltpslcpscpLc....ppthphohDhLG.........Etspsss-Apphhhshtpslpslucpstst...........thhthPshph.phstLh.phs.....shpp-h...shpphlt+lcslsptApchslslplDAE-pphhpho......lclhtc..h.p.tppshsslGsslQAYL+csspslctlhslAp+pshh....htlRLVKGAYh-uEtp+Ap..Gh.s.ssaopcspoDhtap...shschlhtscsh......lastlAoHNscolAhshplscppt.hs...spaEFQpLaGMu-tlpppLspps......hssRhYsPaGsh...pchluYLlRRLhENsuNsuFsp+thshp	....................................................................................................................................Gpsltpshtthcthp....ppGhphoh.D...hLG...................................Essh.stt-.Apthh..tpa.....phlc...slspt.s....s.....................................s.....h....h......photlp..s....+.h..s.........phphct..........shpph.h...s...p.l...pp...l...s...th...A.........c..........p...h..........s...l.t.lsIDAE-tsc...L....-ho...........................lclhcc.....h..............p...........................h.......t........s.......a..........s...s.......l.G..hVlQAYh...+cs..slchLh.chApcp....tht.....lhlRLVKG.AYh-sEhth...up..........G..........h..t........h.ssaoc...Kht.o.Ds..sYh......................shh....c....h..l..L..t...s..sph.......................lasthATHNspol..uth....h.p......h....s..........t...p...p...............h....h............................................................s..p...............aE..F..QhLaG........Mu-s....lhc....p....l..ss..ps............................hss.RlYsPh...Gsh...cs...hluYLlRRLhENs.ANsuFsp+hhp..t........................................	0	297	600	836
+4001	PF00160	Pro_isomerase	pro_isomerase; 	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Sonnhammer ELL, Wuster A	anon	Prosite	Domain	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation.  Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA).  Other roles for cyclophilins may include chaperone and cell signalling function [1].	20.80	20.80	20.80	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.41	0.71	-4.01	168	13237	2012-10-02 15:38:38	2003-04-07 12:59:11	16	154	4706	283	5300	10643	4524	159.30	35	60.14	CHANGED	hlph..ps...........G.plhlc....L.hsctu.PhsspNFl.p.........Lsp..................pG..........................aYc..sshFa......R.l..........lps...F........hl...........Q................uGc...........................................t......ss.............s........................h.sEh..........................................................................p............pt..GsluMA.pt.....................so....s.uSQFFI......sh..............................ts.........................s.......tL..D........s..........ta.slFGcVl..pG...h-.llcpIp.p........s.........................lhIhpstl	....................................................................................h...lpTs......hG.c.I.t.lc...L....a..s..c...t......u.Pp.Ts.c.........N....Fh..s...........L..sp..........................pG.................................................................aY.c....Gs.h.....FHR...V....................................Iss...........F...............................Ml................Q............................G.GD...............................................ss...sst.........................................hut............p....................hpsE.h............................................................................................................tlpp...........tt..GsL.u.MA..psG..........................Pso..................s.GSQ......FFI..sh........................................................................................s.s.......................................ss...........aL..D........s....................pa..sVFG.c....Vl..........cG..............h-...V..l.c..pIp.p..........................stsst.............stPhps..lhItpst...................................................................................................................................................................................	0	1874	3188	4422
+4002	PF00235	Profilin	profilin; 	Profilin	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.69	0.71	-4.00	72	1081	2012-10-02 21:07:43	2003-04-07 12:59:11	14	8	440	49	440	984	4	121.20	33	90.65	CHANGED	SWQuYVD.....ppLhus......Gp.lspAAIlG.p.D...G.u...........lWA...pSss...F.plps....................pEhssIhss.Fpp......s...sslhssGlpluGpKYhslp..u-.....sps..lh.uKKu.psG.....lslhKTspAllluhYs-s...................hpsGp.sspsVE....cLuDYL	..............................................................uWpsYlD......pL.hss..........up..lssAAIlG..pD.....G..s.........................VW..A.pSss.....F.phps.............................pElsslhss.Fs-........s......spltssG..lhluGp..........KYhllp.....u-.............sss....lh..u.....K.....K..u....suG...........lsltKT..s.pAll.lu.hYcEs...................hpsG.p.sshhlcplucYL...................................................................................	0	172	257	346
+4003	PF02161	Prog_receptor		Progesterone receptor	Mian N, Bateman A	anon	IPR000128	Family	\N	24.10	24.10	24.10	24.80	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-13.11	0.70	-5.68	5	113	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	60	0	25	104	0	382.60	60	62.18	CHANGED	MTElpuK-sRAPHsAGussSP..s.pP..tRpDussh.uSQsSD..........s.utsSulPlu.LDuLLFsRpsQup-.P-EKsQ-pQshsDVptA.sclEAocs+GusSsRP..PcpDsssLDSVLDTlLAPSGPuQupsS.PAhEstoSWCLFGPElPEDPRus.uopthloPLMSRPEuKAGDuuGhuuupKs.P+ulSPSRQ.L.PssGustWPGAsuKsusQsAsluVEE-uGhcAEGSsGPLLKGKPRsLuGsuuGGGAsAsAPGs.sGGhs.VPKEDSphuAP+sSLsEQDAPsAPGpSPLATTshDFIHVPILPLNsAaLAARTRQLLEuE.oYDGGA.....FAPPRSSPSAsssPVPuGDFPDCuYPP-u-PK-DuFPlYGDFQPPALKIKEEEEGsEAAuRSPRPYLuAGAuuAsFsDaP......PPhPPRAPsSRPGEuA...sAssususSssSSsGPoLECILYKAEGAPPsQGPFAsuPC+sPuAuuCLLPRDuhs......uAssSuAAPALYsPLGLNGLPQ.LGYQAAVLKEG.LPQVYPPYLNYLRPDSEASQSPQYSFESLPQ	.........................................MTELpAKssRssHsuGusPSP.pluSPL.sR.sss.F.uSQsSD..........s.s.sSulPIS..LDGLLFPR.CQGp-..stKTQspQsLuDV-GAa..stsEAspusG.....usuups..PEKDpsLLDSVLDTLLsPuGstQSpsS.P.A.sEshosWCLFGsELPEDP.us...PuTptlLsPLMSRstsKsGDuSthuAupKlhPpGLSPspQLL.PsssustWsGAssKPus.ssssp.sEE.-su.cs-t...ususlLKucPRs.tGssttuth.ssssu.hs.Guhs.sP+EDuRhsAs+suL.E.pDuPhAPGRSPLAToh..hDFhHVPILPLstAhLAAR..TRQLLEt-.sYDGGA.........FusPRuSPsAsSsslssuDFP-ssY.s.-s-sK-ssa....shau-FQ.PsLKIKEEptusps.........sYhsuustsss.h.ch..............s.ps...............................s.sssLEClLYKAEs..A.st.....ssass.Ps+ssusuuClLP.tp................s.ssuuu...sP....slY.sLuLNGh.Q.LGYQA.AVlK-u.LsQVYPPYLNYL..R.PDoEsSQSPQYuF-SLPQ...........	0	2	2	6
+4004	PF02244	Propep_M14		Carboxypeptidase activation peptide	Bateman A, Mian N	anon	Pfam-B_2335 (release 5.2)	Domain	Carboxypeptidases are found in abundance in pancreatic secretions.  The pro-segment moiety (activation peptide) accounts for up to a  quarter of the total length of the peptidase, and is responsible  for modulation of folding and activity of the pro-enzyme.	22.10	22.10	22.10	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.14	0.72	-4.31	103	1016	2009-01-15 18:05:59	2003-04-07 12:59:11	11	15	167	24	581	999	1	73.10	22	16.68	CHANGED	a+l...pspsppplplLppLp...ps.plcFWpsss....thspssclhVsspphtshpshLpppslpaplhlpslQphl-pEp	.........................hcl.spspppl.phLppLp...........pp.pl.cFWpsss.......t.sps.lDlhVss..p.ph...p.s.hpshLppp.sl.p.a.p..lhlc.slQphl-pp.........	0	141	201	408
+4005	PF04352	ProQ		ProQ/FINO family	Mifsud W, Moxon SJ, Bateman A	anon	COG3109 & Pfam-B_7673 (release 7.7)	Domain	This family includes ProQ, which is required for full activation of the osmoprotectant transporter, ProQ, in Escherichia coli. This family includes several bacterial fertility inhibition (FINO) proteins. The conjugative transfer of F-like plasmids is repressed by FinO, an RNA binding protein. FinO interacts with the F-plasmid encoded traJ mRNA and its antisense RNA, FinP, stabilising FinP against endonucleolytic degradation and facilitating sense-antisense RNA recognition [2].	21.70	21.70	21.80	22.00	21.00	21.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.39	0.71	-4.47	46	1580	2009-09-11 08:23:37	2003-04-07 12:59:11	8	2	1071	7	186	857	21	115.00	41	57.46	CHANGED	p+hsss.ppslshLtcpFPtsFstpst.hpPLKlGIapDLhtclpptt...lS+spLRpALppaTpuhRYLpuh.ptGssRlDLsGpssutlot-csp+ApppLtcp+p.csttcctppt..s	.............................phpsscEslshLtcpFPtsFss..-st...s+PLKlGIhpDLl-cl....ut..c........LS+spLRsAL+hYTp...ShRYLtul.KsGAsRhDL-G..pPs....Gclsppcsp..aAppp......Lpct+s...+sptpcttQ.ut........................................	0	25	76	133
+4006	PF02428	Prot_inhib_II		Potato type II proteinase inhibitor family	Bateman A	anon	Pfam-B_2913 (release 5.4)	Domain	Members of this family are proteinase inhibitors that contain eight cysteines that form four disulphide bridges. The structure of the proteinase-inhibitor complex is known [1].	20.40	20.40	20.90	20.40	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.21	0.72	-3.91	10	341	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	42	25	13	355	0	48.10	62	74.95	CHANGED	sKACTpECDPclAYuhCPRSEGs..h.sslCTNCCuGhKGCpYYusDGoFICEG	.......PKACP+NCDsRIAYulCPpSEpp..tps.pICTNCCAG...p..KGCpYFSsDGTFlCEG............	0	1	8	11
+4007	PF00260	Protamine_P1	protamine_P1; 	Protamine P1	Finn RD	anon	Prosite	Family	\N	20.50	20.50	20.70	20.60	17.20	17.60	hmmbuild  --amino -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.00	0.72	-4.15	14	147	2009-01-15 18:05:59	2003-04-07 12:59:11	15	1	133	0	9	97	0	47.40	74	96.52	CHANGED	ARY.RsCRSpSRSRC.RRRRRRs+...............RRRRRpsRRRR...Rt..ssRR...Ysh..RpRR	.ARYRCCRSpS..RSRC..RR...RRRCR.RRRRRCCRRRR.Rs..CCRR...YThhRCtR..	0	1	1	1
+4008	PF00841	Protamine_P2	protamine_P2; 	Sperm histone P2	Bateman A	anon	Pfam-B_1350 (release 2.1)	Family	This protein also known as protamine P2 can substitute for histones in the chromatin of sperm (Swiss). The alignment contains both the sequence of the mature P2 protein and its propeptide.	25.00	25.00	25.30	37.70	24.10	18.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.63	0.72	-3.43	4	60	2009-09-11 10:14:09	2003-04-07 12:59:11	14	1	43	0	8	54	0	92.80	65	88.38	CHANGED	MVRYRVRSPSEsPHps.tQphcspEQG....p-QGLSPEcVEsYGRTHpG+aHYR+RpCSRRRLhRlH+p.+RSCRRR+R+uCRHRR........R+RRGCRpR	.MVRYRhRSPSEpP..Hps.GQ.phctpEQG....ptQGLSPE+VEsY.GRTHRG+p.HaR+R+CSRRRL+RIHRR..+RSCR.RR.RR...RSCRHRR...........RHR..RGCRpp...........	0	1	1	1
+4009	PF03247	Prothymosin		Prothymosin/parathymosin family	Bateman A	anon	Pfam-B_3463 (release 6.5)	Family	Prothymosin alpha and parathymosin are two ubiquitous small acidic nuclear proteins that are thought to be involved in cell cycle progression, proliferation, and cell differentiation [1]. 	23.90	23.90	24.10	24.20	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.24	0.72	-11.24	0.72	-3.89	8	185	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	42	2	61	210	0	90.50	59	75.61	CHANGED	uDsuVD..uusElosKDLKEK.KElVEEsEsuK-....sPsNGst.sEENGppcuDsp.--EEEs..-E--EE--G-G---Es---E.......Es-GsTsKRAAE...-E-D-s-sKKQKTD-sD	............u-tsV-..susElosKDLKEK.KEl..VEEuENG..+-......APANGNs...NEENGEpEuDsEs-EEEEp......tE-p.....E......EE-s....-.GEEE-s-E-E.......E.sEusssKRAAE.......pE-D-lDsKKQK.T-ps................	0	3	8	21
+4010	PF05044	HPD	Prox1;	Homeo-prospero domain	Moxon SJ, Bateman A	anon	Pfam-B_5293 (release 7.7)	Domain	Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos.  It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain.  However, the structure shows that these two regions form a single stable structural domain as defined here [1].  This homeo-prospero domain binds to DNA.	25.00	25.00	42.70	42.70	22.60	21.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.94	0.71	-4.56	13	191	2009-09-11 05:20:22	2003-04-07 12:59:11	7	3	88	3	116	167	0	139.90	65	21.88	CHANGED	psLTPhHL+KAKLMFFYTRYPSSslLKsYFPDV+FN+ssTuQLlKWFSNFREFYYIQMEKaARQALuEGlsssc-lhVo+DSELa+sLNhHYN+sNchEVP-pFltVsppTLREFFsAIpuGKDs-PSWKKsIYKVIs+LDcpIPEhFKSPNaL-cLp	..................p.sLoPsHLKKAKLMFFaTRYPSSshLKsY...FsDVKFNRClTSQLIKWFSNFREFYYIQMEKaARQAls-GVos........s........c..-LslsRDsELaRuLNhHYNKuNDFE.....V.P.-pFlcVsphTL+EFFpAI.uGKDs-PSWKKsIYK...lIs+LDs.lPEhFKossh.....................................................	0	23	31	75
+4011	PF02840	Prp18		Prp18 domain	Bateman A	anon	Bateman A	Family	The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known [1]. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles [1].	22.10	22.10	22.30	22.30	21.10	22.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.81	0.71	-4.38	29	352	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	294	2	249	327	2	137.60	42	40.45	CHANGED	l.............htalphl.....LpcWcppLpscppp....tpohpuc.s........hsthhQT+cpl+PLhcpl+p....p..pLspDILpsLspIlpthp.pRc.......YhcAsDuYlcLuIGNAsWPlGVTMVGIHpRo.....uRpKIau.sp....l..AHlhNDEpTRKYIQulKRLlTFsQphaPs.c	..............................................htahphlLppWtppLspcppt................+pohpGK.s.................sshhQocchl+PLF+pl+c.........p..sLssDIhpslsc.Il.ct.h..p.Rc.......YlcAsDuYLcluIGNAsW.....PIGVTMVG.IHtRo.....uREKIas...pp.....lAHlhsDEspRKYlQulKRLhThsQppaPsc.........................	1	85	132	201
+4012	PF02340	PRRSV_Env		PRRSV putative envelope protein	Bashton M, Bateman A	anon	Pfam-B_939 (release 5.2)	Family	This family consists of a conserved probable envelope protein  or ORF2 in porcine reproductive and respiratory syndrome virus (PRRSV) also in the family is a minor structural protein from lactate dehydrogenase-elevating virus.	25.00	25.00	27.00	29.20	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.51	0.70	-5.19	4	222	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	9	0	0	236	0	230.50	83	92.22	CHANGED	Mh.hSSLhPhLI.hF.hsFCLu.PSPsGhW.hhSDWFuPRaSVRs..hT..sYRR.acshlp.CpPDl.paG.Kt.hGMLWHMKVuThlD-hlppRlhppMpHpGptsWtQVhoctsLppIushslVsHhQplAulEtEuCpYLhSRLPhlpshussh.NVTIpa...LNpshhI..uPuspshhss.+.WLlShpSSlFSSVAAussLaIVhhLRlP..RpVFGFhahpts++o	.................................MLSRs.WCPLLISSYFWPFCLAS.SPVGWWSaASDWFAPRYSVRALPFTLSNYRRSYEAFLSQCQVDIPTWGsKHPLGhLWHHKVSTLIDEMVSRRMYR..IMEKAGQAAWKQVVSEAT.....L.....SRIS.uLDVVAHFQ.HLAAIEAETCKYLASRLPML.H.NLRhTGSNVTIVYNSTLsQVFAIFPTPGSRPKL.HDFQQWLIAVHSSIFSSVAASCTLFVVLWLRIPhLRoVFGFRWLGAhF......	0	0	0	0
+4013	PF01366	PRTP		Herpesvirus processing and transport protein	Bateman A	anon	Pfam-B_1171 (release 3.0)	Family	The members of this family are associate with capsid intermediates during packaging of the virus.	20.30	20.30	24.90	24.60	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	638	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.96	0.70	-6.53	32	211	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	109	0	0	193	0	587.10	37	83.17	CHANGED	htQcLsAlhuQlpshshplplL+hCDPss..h...hphsslphNshhlphLpcplhstLtpQs.phpsosLoltLphhLcshptcsttlhpuLp...p............tppaFppsh...tLs..ttCshHpplplshYG.sttlslplshlNDlEphLKpLNhsahhlsspsulpslpplhpFLschhGsuslssP-lYssop.PCh.Ca-ELslssNQGcolp+RLhsphCsHlspph....lpsth-s.lpplshshshsspch.......t.ht......................htspptpsps..................hhppAtphLcsaslFp.ssstplYplS-LpYWsuoupt...............tsshcthsssLspLhp+Epphcthpstl.phhlhscsspHFhchatsp.............sh-pLasGuhhsSs--hI-ALhpsChspahspPhhpcLhppps-hhstLpplLpphp............................sssssssststs...................................................t....phst.ttsp.t......................................................pshp-sphR+ctYhc+lo+cuhspLtpClcpQcc.LpKhLslsVaGsslhcphsplhNtFhtRptalpts.htst........spssstsF-sppal+ssLhppplssphLssLsppFacLlNGPLhscs.chFs.PsNssLhasl-ssGlLPHhKp-Lschhhsshps.pDWhsspFppFYsF....ss...pslsssQ+hs	....................h.hQ+LhslhupsppashplEhL+hCDPpl..hh..tc.sshKhNuhtlhhLh+plhPtlhtQs.ptp.o.LolhLchlLcthhc-sthL.tuLtsat......t...t.D.........httaappsh...tLs....CshHpplpLphhs.ss.hshpLshLpDlEpFLpphNasahlhsspsultshtplhphLtphsGhu.ls..Elas.up.sCh.CaEELslhsNQGcolp+RLtshlCsHlshp....pspsp.-s.hppl.pshh..stchs...tslsslct.....................l.upsss.ps...................hhp-ApthLctaslFp.shstplYulS-hpaW.tou.................pshhcths.slppLshhcp.hhcthhssl.phtLaGcpscch.thhtt.tls...........h.-plhlGuhhsuPschI-hlhphshpta.ssPlhp+L.p.ppp.hstl+plLpclp......................................s............s......................................................t...................................................................shtthhppstp-sphR+RtYhp+lSchuhuplh+Cl+pQcp.lpKhlcVNlhGplhhchhuplhNGFhhRppahpts...ss........shusthsaDtHhalhssLl++plssthLPtLspphacLlNGPLFsHspcpas.P.Nsshhaus-NsGlLPHlK--Ls+hh.u............ssts...s-WhVscaptFasF......ss..hpslsshQ+th.............	0	0	0	0
+4014	PF02666	PS_Dcarbxylase		Phosphatidylserine decarboxylase	Bashton M, Bateman A	anon	COG0688	Family	This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65.   These enzymes catalyse the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2.  Phosphatidylserine decarboxylase plays  a central role in the biosynthesis of aminophospholipids by converting  phosphatidylserine to phosphatidylethanolamine [2].	20.00	20.00	20.20	20.30	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.26	0.71	-5.02	112	3949	2009-01-15 18:05:59	2003-04-07 12:59:11	10	31	3153	0	1299	3080	1984	203.70	27	63.28	CHANGED	hstaFsRth+sst..Rsl......stsss..........hllSPuDGplhth...l.....tt................h.hKt...hthtphlss..................................................................................................................ps..shhlslaLuPtDYH+h+sPssGplpp.hpahsGch...................h...............................sss.hthpp.................................................pNERshhhhp......hu.t......hhhltluuhhlspIhhth.t.........................................................................tstplp+GcchGhFph.GSsllllh.ts.h..................p.plphGp.plphGps.ls....t	..................................................................................................hstFFsRhl+sss........R..s..l..............spsss..........................hlluPADGt.l......sph...sp.l..p..ttp................h..h.KG...ta.shppL.Lus...........................................................................................................................................................................hps..shhsslaLuPtDYHRhHhPss.G.p.l.p.c....h.hahs.Gc.h........a.........................................................sVs.hpupp..............................................t.h.h.s.c.N.E....Rshhlhc.......sphG..............................hshl.VGAhhVupIhh..sh......................................................................................................ptu.plp+Gc-hGhF+h.GSTl.l.l.lhstst.....................p...p..lp.....sp...hsphGptlh.t.........................................................................................................................	0	425	811	1087
+4015	PF04230	PS_pyruv_trans		Polysaccharide pyruvyl transferase	Kerrison ND, Finn RD	anon	COG2327	Family	Pyruvyl-transferases involved in peptidoglycan-associated polymer  biosynthesis.  CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides.  WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora [1].	25.30	25.30	25.40	25.40	24.80	25.20	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.77	0.70	-4.70	163	2481	2012-10-03 16:42:30	2003-04-07 12:59:11	8	39	1781	0	656	2150	297	275.20	15	70.68	CHANGED	NhG.Dtl...........hhuhhphLpptt..psplhshs.......t.ttttthht.h...............................................................................................lllsGu...................................t.....hh..........hhhhhhtpthpp.h.......lhhutuh...................t...h..............ppttpp...hhpphhpp.hsh...lslR-ph.Shp.........htphsh.......psthssDss.h..hht..................................ttthhthtptst................t.thtphhhhhhphhhp.pthphhhh.ht.t.t.t..p.h............................h.hh...hsspchhshls.pschllssRhHuhlhuhhhshPsl.slsh.ss	................................................................................................................................................................................................................................NhG.s.h....h....hhuhhph.l....pp.........t...p....h....ph.shs......................t....t.t.....h.ht.h...h..................................................................................................................................................hlhsGu............................................h..h............hthhhhsth.hpp...h.......................hhhutul...........................us..ht.................................stthpp...........hhp.hh..hsp..ssh.....lslR-ph.Shc......hhpphslp................psphssDss.h......hls.......t...t..........................................................htthh.http.t...............................tth..t..pt.hhthhph..hhp.........pthp.hhh.h..s..hth.t...t........p.h..........................................................thh.h.h...t.hs...st...ch.hph...ls..psch.slusRhHuhlhuhhhshPhl.sls.........................................................................................................................	0	230	461	572
+4016	PF00223	PsaA_PsaB	psaA_psaB;	Photosystem I psaA/psaB protein	Finn RD	anon	Prosite	Family	\N	19.00	19.00	20.60	19.50	17.90	17.50	hmmbuild  -o /dev/null HMM SEED	684	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.30	0.70	-6.45	22	3289	2009-09-12 09:11:12	2003-04-07 12:59:11	14	18	1996	14	178	2825	824	538.70	58	96.78	CHANGED	FSpsLApsP.....TTphIWphhAsAHD.F...-oHsu.s.Epl.pKlFuuHFGHLAlIFlWhSG.hFHsAh.uNapsWlpDPhpl+P.ApslW.PhhGQphls......scsGush...shhssSGlaphWhshGhsophpLhtsulhhLlhAulhLaAG............WhH.hp.th........................PpLtW........FpssEShLNHHLuuLhGluSLAWuGHhlHVAlPhsphhcs.............hsshhpl.PhPpsL.......................sPFFohNWutYup..................hLTFpG.....G...LpPtTGuLW..LTDlAHHHLAIAllFIlAGHMYRTsa.GIGHshKEll-upps.................hs.uHpGLa-hlssShHhQLulsLAhlGolo.lVApHMYuhPsYsYlupDYsTphuLaTHH.aIuGFlhVGAhAHuuIFhVRDY..DPthN..........tsNlLsR.......lLcH+-AIISHLsWVslFLGFHohGLYlHNDoMpAhGcPp.....ptI.lpPlFAQaIQuhp..upsh........sssu....s......s.s.hhsG....lsuls.scss.hhl.lGsuDFLVHHhhAhslHsTsLILlKGsL.ARuS+LhPDKtshGapFPCDGPGRGGTCplSuWDphaLulFWMhNoluhVhFaapWKh.S.hhGss................................................upFspSShhlsGWLRDaLWtpSSQlIsuYssh.....LSsauhhFLhuHhlWAhuhMFLhShRGYWQELIEolVWAHpKh.lAstI.......pPhALSIsQGRhVGlsHahlGsIhThhAFhlA	............................................................................................................................................................................s.Ecl.pplFuuHFGQLuIIFlWhSG.hFHsAh.uNapuWlpsPhpl+P.ApslW...PhhGQ.hlp.............scsGush.s..hhSGhaQhWhs.GlpophpLYssAlhhLhh..uulhLhAG............WhH.hp.th........................PplpW........FpNsEShLNHHLuGLhGluSLuWsGH.lHVulPhs+h.cs.............hss.h.-l..Ph.Ppth....................................sPFFohsWs.Yup..................hLTFhG.....G...h.pP.TtuLW..LTDhAHHHLAIAlLFll.AGHMYRTNa...GIGHShK-lLEAHpsP..................hhGpGHKGL.Y.-hl.ss.ShHhQLulsLA.lGslo.lVA..pHMYuhPsYsalApDasTQhuLaTHH.aIuGFhhsGAhAHuAIFhlRDY..sPp..ps..........hsNl....LsR.......hLcH+-AIISHLsWsslFLGFHohGLYlHNDsM.AhGpPp.....p.tI.lpPlFAQWIQssH..uhsshsh.....................ussu......u............spo.h.hh.sG......l.sAls.sp.s...h.lslGs.uDFLVHHhhAhslHsTsLILl.......KGsL.ARuS+L...hPD..KtshGapFPCDGPGRGGTCphSsa.D.t.h....................................................................................................................................................................................................................................................................................................................................................	1	36	97	152
+4017	PF02531	PsaD		PsaD	Bashton M, Bateman A	anon	Pfam-B_1336 (release 5.4)	Family	This family consists of PsaD from plants and cyanobacteria. PsaD is an extrinsic polypeptide of photosystem I (PSI) and is required for native assembly of PSI reaction clusters and is implicated in the  electrostatic binding of ferredoxin within the reaction centre [1]. PsaD forms a dimer in solution which is bound by PsaE however PsaD is monomeric in its native complexed PSI environment [1].	22.40	22.40	24.20	24.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.57	0.71	-4.97	20	196	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	148	6	61	196	124	127.70	66	81.82	CHANGED	ssLssps..PhFGGSTGGLL+uAEsEEKYAITWTSpKEQlFEMPTGGAAlM+cG-NLLYLARKEQCLALuT.QLRs+F..KIpDYKIYRI..FPsGEVpYLHPKDGVFPEKVNtGRtslGpssRpIGpNsNPsslKFoGK.psa-	.............Lssps..PhFGGSTGGLLppApsEEhYsITWsSsKEQlFEMPTGGAAIMpcGpNLLhLARKEQCLALG.T.QLRoKF..KIpcYKIYRl..FPsGElQYLHPKDGVaPEKVN.GRptVGps.RpIGcNssPhplKFoGKtsa-.......	0	19	43	56
+4018	PF02605	PsaL		Photosystem I reaction centre subunit XI	Bashton M, Bateman A	anon	Pfam-B_1741 (release 5.4)	Family	This family consists of the photosystem I reaction centre subunit XI, PsaL, from plants and bacteria.  PsaL is one of the smaller subunits in photosystem I with only two transmembrane alpha helices and interacts closely with PsaI [1].	25.00	25.00	40.70	39.20	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.99	0.71	-4.69	21	179	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	141	6	63	174	145	149.10	48	79.09	CHANGED	pphlpshs.DPhVGsLuTPlsoSsho+sFIsNLPhYRpGLSPhhRGLElGMAHGYFLhGPFshLGPLRN.o-hAhlAGLLuulGLllILTssLohYGsls.........spsssh....................................-sLpTpcGWupFsuGFhlGGsGGAhaAahLlpsh.l.ts	.........h.phlpPhssDPhlGs.LtTPlsSSshsthalsNLPAYRpGlSPlhRGLElGhAHGYhLlGPFshh...GPLRs.o-hAthAGhLuAlGLVlILTlsLolYGhsuFpp......spssss...shsh...p..........................s.-sLpTscGWupFouGFalGGhGGuhaAahLltslth..sh........	0	20	47	59
+4019	PF00737	PsbH	PSBH; 	Photosystem II 10 kDa phosphoprotein	Bateman A	anon	Pfam-B_465 (release 2.1)	Family	This protein is phosphorylated in a light dependent reaction.	20.80	20.80	20.80	21.30	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.50	0.72	-4.39	19	1173	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	1095	17	62	665	119	39.10	76	66.99	CHANGED	pTtLGslLKPL.NSEYGKVuP..GWGTTPlMulhMsLFhVFLlIILpIYNsSllL	........TslGslLKPL..NSEY.GKVAP..GWGTh.hM.............................	1	14	42	56
+4020	PF02532	PsbI		Photosystem II reaction centre I protein (PSII 4.8 kDa protein)	Bashton M, Bateman A	anon	Pfam-B_1731 (release 5.4)	Family	This family consists of various Photosystem II (PSII) reaction centre I proteins or PSII 4.8 kDa proteins, PsbI, from the chloroplast genome of many plants and Cyanobacteria. PsbI is a small, integral membrane component of PSII the role of which is not clear [2].  Synechocystis mutants lacking  PsbI have 20-30% loss of PSII activity however the PSII complex is not  destabilised [2].	19.30	19.30	19.50	25.70	18.50	17.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.58	0.72	-4.33	15	674	2009-09-11 13:22:19	2003-04-07 12:59:11	9	2	643	17	44	216	33	35.40	85	96.30	CHANGED	MLsLKlsVYsVVlFFVuLFlFGFLSsDPuRNP..sR+D	.....MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRcE......	0	13	31	40
+4021	PF01788	PsbJ		PsbJ	Bashton M, Bateman A	anon	Pfam-B_1227 (release 4.2)	Family	This family consists of the photosystem II reaction centre protein PsbJ from plants and Cyanobacteria.  In Synechocystis sp. PCC 6803 PsbJ regulates the number of  photosystem II centres in thylakoid membranes, it is a predicted 4kDa protein with one membrane spanning domain [1].	21.20	21.20	21.20	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-7.91	0.72	-4.42	25	1304	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	1239	17	50	454	91	31.80	78	95.70	CHANGED	Mus...TGRIPLWlVuTVuGluslullGlFFYGSYuGLGSSL	......MAD..TTG.RIPLW..l.IGTVsG.I.VIGLlGlFFYGSYSGLGSSL......	0	14	34	45
+4022	PF02533	PsbK		Photosystem II 4 kDa reaction centre component	Bashton M, Bateman A	anon	Pfam-B_1331 (release 5.4)	Family	This family consists of various photosystem II 4 kDa reaction centre components (PsbK) from plant and Cyanobacteria.  The photosystem II reaction centre is responsible for catalysing the core photosynthesis reaction the light-induced splitting of water and the consequential release of dioxygen.  In C. reinhardtii the psbK product is required for the stable assembly and/or stability of the photosystem II complex [1].	25.00	25.00	25.50	25.50	23.10	22.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-7.99	0.72	-4.02	25	756	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	711	17	53	470	13	40.60	78	72.83	CHANGED	shllAp..LPEAYuhFcPlVDVLPlIPlhFhLLAFVWQAAVuFR	..s.hFFuK..LPEAYAhhsPIVDVMPVIPlhFFLLAFVWQAAVSFR..	0	13	35	46
+4023	PF02419	PsbL		PsbL protein	Bateman A	anon	Pfam-B_1884 (release 5.4)	Family	This family consists of the photosystem II reaction centre protein PsbJ from plants and Cyanobacteria. The function of this small  protein is unknown. Interestingly the mRNA for this protein requires a post-transcriptional modification of an ACG triplet to form an AUG initiator codon [1,2].	19.70	19.70	20.40	20.40	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.29	0.72	-7.54	0.72	-4.53	14	1035	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	985	17	49	215	89	36.70	90	86.43	CHANGED	pssNPNppsVELNRTSLYhGLLLlFVLulLFSSYhFN	...TQSNPNEQ.NVELNRTSLYWGLLLIFVLAVLFSNYFFN.....	1	14	32	41
+4024	PF05151	PsbM		Photosystem II reaction centre M protein (PsbM)	Moxon SJ	anon	Pfam-B_6558 (release 7.7)	Family	This family consists of several Photosystem II reaction centre M proteins (PsbM) from plants and cyanobacteria. During the photosynthetic light reactions in the thylakoid membranes of cyanobacteria, algae, and plants, photosystem II (PSII), a multi-subunit membrane protein complex, catalyses oxidation of water to molecular oxygen and reduction of plastoquinon [1].	21.10	21.10	21.40	21.40	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.06	0.72	-4.35	19	1155	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1094	17	44	275	4	26.80	81	83.33	CHANGED	MEVN.LGFlAolLFlllPTsFLlILYlpTsu	......MEVN.LuFIAosLFILVPTAFLLIIYVKTVS..	0	11	30	40
+4025	PF02468	PsbN	psbN; 	Photosystem II reaction centre N protein (psbN)	Mian N, Bateman A	anon	Pfam-B_2222 (release 5.4)	Family	This is a family of small proteins encoded on the chloroplast genome. psbN is involved in photosystem II during photosynthesis, but its exact role is unknown.	20.40	20.40	20.60	20.50	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.16	0.72	-4.34	32	1871	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	1799	0	52	442	322	43.00	83	95.48	CHANGED	ME...sAhhlsIhluslLlulTGYulYsuFGPPS+pLcDPFE-HED	.........ME...TATLVAI.ISsLLVSFTG.YALYTAFG.QPSpQLRDPFEEHtD...	0	14	38	48
+4026	PF04725	PsbR		Photosystem II 10 kDa polypeptide PsbR	Kerrison ND	anon	DOMO:DM04871;	Family	This protein is associated with the oxygen-evolving complex of photosystem II.  Its function in photosynthesis is not known.  The C-terminal hydrophobic region functions as a thylakoid transfer signal but is not removed [1].	21.80	21.80	21.90	23.50	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.37	0.72	-4.00	5	100	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	62	0	33	95	1	92.70	63	71.49	CHANGED	SGuKKlKTD........cPY......GhGGGMsl+sGVDASGRKuKGKGVYQFVDKYGANVDGYSPIYoP-EWSPSGDVYVGGTTGLhIWAVTLAGLLuGGALLVYNTSALAs	..................................usKKIKTD..............pPa......GhuGGhsl+sGlDASGRKuKGKGVYQFVDKYG.ANVDGYSPIYss--WSsoGDVYsGGsTGLhlWAlTLuGlLuGGALLVYsTSALu.........	0	8	21	29
+4027	PF01405	PsbT	PSBT; 	Photosystem II reaction centre T protein	Bateman A	anon	Pfam-B_1880 (release 3.0)	Family	The exact function of this protein is unknown. It probably consists of a single transmembrane spanning helix. The Swiss:P37256 protein, appears to be (i) a novel photosystem II subunit and (ii) required for maintaining optimal photosystem II activity under adverse growth conditions [1].	20.30	20.30	20.50	20.50	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.89	0.72	-6.96	0.72	-4.36	3	1892	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	1795	17	44	477	0	27.70	90	83.23	CHANGED	MEALVYlFLLlGTLuVIFFAIFFRDPPRI	....MEALVYTFLLVSTLGIIFFAIFFREPPK.V..	0	12	31	41
+4028	PF03912	Psb28	PsbW; 	Psb28 protein	Finn RD	anon	DOMO:DM04467;	Family	Psb28 is a 13 kDa soluble protein that is directly assembled in dimeric PSII supercomplexes.  The negatively charged N-terminal region is essential for this process [1]. This protein was formerly known as PsbW, but PsbW is now reserved for Pfam:PF07123.	25.00	25.00	56.40	56.40	18.70	17.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.38	0.72	-4.09	34	184	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	126	1	63	178	102	103.70	44	82.25	CHANGED	IQFhcGlsEpllP.-VRLTRS+.DGssGpAhFhFcpPps..lst.pt.s..-ITGMaLlDEEGEltTR-Vpu+FlNG.....cPpulEAsYhhcopp-W-RFMRFMcRYApsNGLuas	.IQFhpGlsEpllP-V+LTRS+.sGssGsAhFhF-pPps..l-ptps..p.tsITGhaLID-EGElsop-VsuKFlNG.....cPptlEutahhco.p-W-RFMRFMcRYuptNGLsa.....	0	18	45	59
+4029	PF00849	PseudoU_synth_2	YABO;	RNA pseudouridylate synthase	Bateman A	anon	Pfam-B_421 (release 3.0)	Family	Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD Swiss:P33643, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA [1].	23.80	23.80	24.10	23.90	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.13	0.71	-4.41	57	25319	2009-01-15 18:05:59	2003-04-07 12:59:11	17	48	4782	26	5572	17465	6565	147.20	25	50.03	CHANGED	ph.lllsKPtGhsspsts............................thtthhth.hhtt..tpttphthlpRLD+sooGlllhupssphspplpp.h....tppp.lcKpYhuhl.............................................h...ptshhp..h..............................................................................ssptshshhcslpps.........................................sphshlplplhoG+pHQlR...tphst	.............................................................................................................................................................llllNKPtGhlspsss......................................................................................................t..t..h...h..h..h..h..h.h.t........ttst...c..h...hhVt..RLD+..........-ToGL...........ll..l..s.p.s..s.pht.p.pLtc...............................p+p....l....p....K....pY.hAhVp.....................................................................................................................................................................t...t...t....h...l..p...t...s.l.tp.................................................................................................................................................................................................................h.....h.....h.....h.....h...h....p....s....u....p...s.......u....h...o...p.h..chlpph.............................................................................................t.s.h..ohl..c.lplp.p....G..RsHQlR...hhht.........................................................................................................................................................................................................................	0	1812	3469	4634
+4030	PF00796	PSI_8		Photosystem I reaction centre subunit VIII	Bateman A	anon	Pfam-B_528 (release 2.1)	Family	\N	19.80	19.80	19.80	19.80	19.40	19.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.46	0.72	-6.76	0.72	-4.36	36	650	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	624	7	44	352	15	23.70	74	61.13	CHANGED	LPSIhVPlVGLlhPAlsMulLFlaI	.LPSIFVPLVGLVFPAIuMA.LaLal...	0	11	31	39
+4031	PF02427	PSI_PsaE		Photosystem I reaction centre subunit IV / PsaE	Bateman A	anon	Pfam-B_1594 (release 5.4)	Domain	PsaE is a 69 amino acid polypeptide from photosystem I present on the stromal side of the thylakoid membrane [1]. The structure is comprised of a well-defined five-stranded beta-sheet similar to SH3 domains [1].	20.90	20.90	21.40	23.50	19.50	20.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.19	0.72	-4.60	25	181	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	147	11	65	180	119	62.20	61	69.39	CHANGED	lpRGSKVRILR.ESYWap-VGTVAoVDpoG..l+YPVlVRF-KVNY.......uGlNTNNFAhcEL.clt	...pRGuKV+ILR.ESYWaN-lGoVsoVDpuu..l+YPVlVRF-KVNY.......uGlsTNNFA.cElpcV.............	0	19	45	58
+4032	PF02507	PSI_PsaF		Photosystem I reaction centre subunit III	Mian N, Bateman A	anon	Pfam-B_2122 (release 5.4)	Family	Photosystem I (PSI) is an integral membrane protein complex that  uses light energy to mediate electron transfer from plastocyanin to ferredoxin. Subunit III (or PSI-F) is one of at least 14 different subunits that compose the PSI complex.	21.10	21.10	21.80	22.00	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.15	0.71	-4.72	10	178	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	141	6	65	172	142	142.20	43	86.29	CHANGED	phhAllhL.slhls....sPssusADlAGLsPCpESsAFpKRtKsolK+LpppLtpY-PsSuPAlAlptph-+TKpRF-pYupAGLLCGsDGLPHLIsDG....RaoHAGEFllPGlLFLYIAGWIGWVGRuYLlAVpsocc.PT-KEIIIDVPLAlKhhhsGFsWPlAAhpEatSGcLlA+D-	............................................t....hhh.shhh.......s.....shs.ph..us.LTPCp-S.tFtp+tptthppht......tstos............ptRF-pYups..LCG.s.DGLPHLIssG.........chs.HhG-FllPulhFLYIAGWIGWsGRsYLhslp..p.p..cp..ss.pEIIIDVPLAhphhhpGhhWPluAhpEhhsGcLhtp-.s.......	0	19	42	58
+4033	PF03244	PSI_PsaH		Photosystem I reaction centre subunit VI	Bateman A	anon	Pfam-B_3007 (release 6.5)	Family	Photosystem I (PSI) is an integral membrane protein complex that uses light energy to mediate electron transfer from plastocyanin to ferredoxin.	25.00	25.00	25.40	25.40	18.80	16.60	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.72	0.71	-4.94	6	67	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	39	4	27	66	2	124.50	62	96.53	CHANGED	olssVpPo.slKGLAGSSluGtKLtl+su.huh.+ssppRAsuVVAKYGDKSVYFDLEDluNTTGQWDlYGSDAPSPYNsLQSKFFETFAuPFTKRGLLLKFLlLGGGSLlsYhSusuutDl.LPIp+GPQpPPclGP....RGKI	....................ssspPs...s.lpGLuGSS....lsGpKLsh.+Pupp.uh...+sps......h..RuuuV.VAKYGDKSVYFDL-DluNTTGQWDLYGSDAPSPYNsLQSK.FFETFAuPFTKRGLLLKFLlLGGGuhlsYhuusuosDl.LPIK+GPQ.PPp.GP....RsKl...................	0	8	20	25
+4034	PF01701	PSI_PsaJ		Photosystem I reaction centre subunit IX / PsaJ	Bashton M, Bateman A	anon	Pfam-B_1599 (release 4.1)	Family	This family consists of the photosystem I reaction centre subunit IX or PsaJ from various organisms including Synechocystis sp. (strain pcc 6803), Pinus thunbergii (green pine) and Zea mays (maize). PsaJ Swiss:P19443 is a small 4.4kDa, chloroplastal encoded, hydrophobic subunit of the photosystem I reaction complex its function is not yet fully understood [1]. PsaJ can be cross-linked to PsaF Swiss:P12356 and has a single predicted transmembrane domain it has a proposed role in maintaining PsaF in the correct orientation to allow for fast electron transfer from soluble donor proteins to P700+ [1].	20.50	20.50	21.20	21.30	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.85	0.72	-4.19	31	684	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	652	7	51	324	19	36.80	72	80.63	CHANGED	Mps...hppYLSTAPVluslWhshTAGlLIElNRFFPDhL	......McD...lKTYLSsAPVLuTLWFuh.LAGLLIEINRFFPDAL..	0	13	38	47
+4035	PF01241	PSI_PSAK		Photosystem I psaG / psaK	Finn RD, Bateman A	anon	Prosite	Family	\N	20.60	20.60	21.00	21.30	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.66	0.72	-3.97	9	219	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	131	9	87	209	97	76.60	33	73.61	CHANGED	s..sshVhslshsssLhsstFGhhshpp+ss...usslPhss.............t.........ssGFsLs-lLAhuSlGHllusullhGLpshGsl	.............................................t...oshlhhl.hssslhAhthGhhshpppss......u.ss.lP.ts.............................uGFs...ls-lLAssSlGHIlGhGllL.GLushGs.....	0	19	60	81
+4036	PF00421	PSII		Photosystem II protein	Finn RD	anon	Pfam-B_182 (release 1.0)	Family	\N	20.10	20.10	20.20	20.50	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	437	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.55	0.70	-5.89	19	3769	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	2075	40	249	3264	956	386.90	46	96.73	CHANGED	hGhsWapspshllNssG+LlusHlhHsuLlshWAGuMsLaElAhFsPpc....PMacQGhhlLPahApLGhssu.GG.slss.shhssG...........h.tlhuotllh.GhlFhAhlh.....sh.-.hchFt..hshcsthcLspIhGIHLhLhGlhsFhhshhthhhshs.shWss...DshslTs.s.ssAshaGh.shsPFsssG..........llutHIhsGllsIhuGlaHlhs+P.thhh+AL.hhshEshLS.SlAAlhhhuFlsushhWYsssAhPsEhaGPTt.phsQ...pQthphhVc.....stpLutshush.t.huhhcYlhpSPutthlFt.Gth.+h.slttsWLt.hhh.s..G...................lDhstlhps..Pap...p+huhE..........................Yhp+A.LGpl.phstsshp.suV.hsSPRuWhohuHhshAhhFFhGHLWHuuRshh..shAGh-tslscplEhshh.KlhD	.........................................hll..N.....s..G+LlusHlhHsuLl.....shWAGuMsLaElAhFsPpc....PMacQGhhllPahspLGhssu.GG....sl.ss.h..shhssG............................h.tlhuutllh.GhhahAhlh................sh......-...........h..........hFs.............hshKsp.chspIhGIHLhL.GlusFhhsh.htl....hh....h....hs.shWss........DshtlT................s..h...s.....ss.s..sh.....aG..h...h.......h.s...P..F.s..stG..............IhutHlhhGhlsIluGlaHl.s.+.......P.t...h..h......h..+............uh..........h....h.............shEshLS..SlAAl.hhuFlssshhWasssshP.EhaG.PTt.phsQ........tQth.hhhVp................s.pLutshuph.t.huhhcYlh.psPstthlFt.Gph.ph.sltssWLt..hh.s..G..................................lDh.stlh+s..Pap...p+hSsE..........................Yhp+A.LGpl.plsts....shc.suV.h.sSP...RuWhshuHh.huh.h.hh.GHlWHuuRshh....hG.........................................................................	0	50	157	222
+4037	PF04012	PspA_IM30		PspA/IM30 family	Bateman A	anon	COG1842	Family	This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator [2].	32.00	32.00	32.10	32.10	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.43	0.70	-4.99	11	2762	2012-10-03 05:15:35	2003-04-07 12:59:11	7	5	1843	0	615	1709	167	219.40	26	93.85	CHANGED	slasRltcll+uslschl-chEDPp..+hL-QtlR-hcsplscu+pslAphhApp+phEcclcptpppspchcppAptALstG..............pEpLA+EsltchpshcppspshcsphsptcststpL+pplspLEsKlpph+scpphLtARtpsA+Appplppphushs...ssuAhsphcRhcpKlt-hEsptputupht...........psts....hDtclcptthptss....cpsLupL+utpsp	...................................ulFsRhtcllpuslsshl-..c..sE..D..Pp..+hlcphIp-.hccpLscscpssAcslAppKphpc+lcptptphtchpp+A....ph..A.Lpps....................c-sLA+t...ALtcptphpshl.pshc...pphsphcsshspl...ccp.l..schpp+lsch+..s.+.pp.s.lh..u...........+pp.sAp...........up..p..p..ls...p...p.h..suhs.........hs.s.Ah...tp.h-ch...c.......c+...l..pp....hpAcu.cutspht...............t.ts.............L-pch...uph.tt.ssth............pp.LApL+t....ht...................................................................................	0	180	388	505
+4038	PF04839	PSRP-3_Ycf65		Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)	Kerrison ND	anon	Pfam-B_2979 (release 7.6)	Family	This small acidic protein is found in 30S ribosomal subunit of cyanobacteria and plant plastids.\	      In plants it has been named plastid-specific ribosomal protein 3 (PSRP-3), and in cyanobacteria it is named Ycf65.  Plastid-specific ribosomal proteins may mediate the effects of nuclear factors on plastid translation.  The acidic PSRPs are thought to contribute to protein-protein interactions in the 30S subunit, and are not thought to bind RNA [1].	25.00	25.00	45.80	45.40	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.56	0.72	-3.91	24	145	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	125	1	52	140	129	48.90	60	35.66	CHANGED	LTsYFFWPRsDAWEplKspLEuKsWIsps-+lpLLNpsTElINaWQEps	...LTsYFFWPRcDAWEpLKscLEuKsWIocp-+lplLNpATElINaWQ-p.G..	0	11	35	47
+4039	PF03034	PSS		Phosphatidyl serine synthase	Griffiths-Jones SR	anon	Pfam-B_1414 (release 6.4)	Family	Phosphatidyl serine synthase is also known as serine exchange enzyme.  This family represents eukaryotic PSS I and II which are membrane bound proteins which catalyses the replacement of the head group of a phospholipid (phosphotidylcholine or phosphotidylethanolamine) by L-serine.	25.00	25.00	26.10	25.60	19.60	18.30	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.96	0.70	-5.00	18	319	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	164	0	208	305	10	251.10	42	61.24	CHANGED	PHPAhWRlVhuhuVlYllhLsFLLFQshcss+plh.talDPc.Ltp.ls.c..+pYuts.Cphhossc.......lhpp.hDhFshAHhlGWhsKslllRcahLsWslSlsFElhElTFpHhLPNFpECWWDplILDVLlCNuhGIhhGhhss+hLch+pYcWsul+.......................ch.o..hpGKhKR....hlhQhTPpShst.....................acWtshpo....hpRFhtlhhllhlhhlsELNsFFlKalLthPPsH.lslhRLllashlussulREaYsYl..sDs.pp++l.....GspsWlhhulhhhEsllslKhutp	.....................................PHPAhWRhlhGhuVlYhl.hLhFlLFQ.shpss+phh.halDPp.Lt.......h..h...E....cpYus..s.Cp....lhs.-p...........lhsp.hDhFshuHhhGWhh.KslhIRshhls..WhlSlh..aElhElsFtHhLP.NFsECWWDp...........lILD.lL.lCNuhGIahGMhsscaLch+pYc.Wtulp..............................................................ph.o...hpGKhKR........shhQFTPtsWst.....................hcWhs.pu....hpRhh......tlhhhhlla..l...sELNTFFLKalhhhsspH.lshhRllhhshlsssslRpaYsal.........sDs....sK+l.....Gpp..sWlhhsI....shhEhllslKau.s...........................................	0	90	117	167
+4040	PF01515	PTA_PTB		Phosphate acetyl/butaryl transferase	Bateman A	anon	Pfam-B_799 (release 4.0)	Family	This family contains both phosphate acetyltransferase and phosphate butaryltransferase.  These enzymes catalyse the transfer of an acetyl or butaryl group to orthophosphate.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.76	0.70	-5.37	21	7061	2012-10-02 21:08:39	2003-04-07 12:59:11	14	23	3973	31	1389	5144	3674	287.60	33	59.22	CHANGED	phhchlhcpAc......stpp+IllPEGp-tRlLcAAptlhppGlAp.slLlG..s..-lpt.h.thtlphth.hplhsspss.th.ccasspahchRKpKGhTh-tAcchlp.DsshhushhVchGpADGhVsGsspoTucslRsuLQIItstsGspllSulFlM.hs............cthhhauDCAlsspPsu--LA-IAlpoAcsA+ths.hcP+VAhLSaSThGSucupss-+VtpAspls+ctpP-L..slDGElQhDAAlspcVAppKsPs.SsluGpANVhlFPsLpAGNIuYKlsQRhuphpAlGPIlpGhspPlNDLSRGsSscDIlNssAlTA	....................................................................................h.....lhphup......tt..t+lV..hsE..G..p-.RslcAsthhhpp.sl.sp.slLlG....s..cl.pt..h..t..h..t...h..t......l....p...h........s.........s...hplls...s......p...s..s..................c...p...h.....ht..t....h..h..p..h.tp..t+..........h.........T.......p...Apchlp...csshhushhVptGc......ADuh..l..s.G.sl.p.os.upsl+sslpl.I.t...s.t.s.G..s...p...h..sSuh.h.hh.hhs............spshhhuDsulN..............s.............P..s..............u.cpLA...-IAlt.u.Ac.os.....c..t.F.G............h..-....P.+VAhLSa.Sshs.S.u....p.......s....s....s..........s...p+sppAs.c.ls............c....c..........t..........t..........P.....-.......L.......hlDG..hphDAAls.p.l.up.pK.....h.P.s.....Ss.l.s.G..p.A.slhlFPsLpuGNlsYKhlp.p.h.u...s..h...h.ul.G....PlL..............Ghpp.PVpsLSRusssc-llphsslss..........................................................................................	0	423	876	1160
+4041	PF02126	PTE		Phosphotriesterase family	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR001559	Domain	\N	20.00	20.00	20.00	20.00	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.65	0.70	-5.41	4	1183	2012-10-03 00:45:34	2003-04-07 12:59:11	13	6	947	100	216	791	85	301.20	34	95.71	CHANGED	lshuphGhTLsHEHlphshsuFhpshPptassppt..........................psuthhpcLtch+A+GVcslV-hTshslGRslphltcVuctTslpIVAuTGhYh.sshP........usphcSVEpLTphhlcEIpaGI-sTuIKAGIItphssu..tlTPhpE+VLcAsApAptpTGsPloTHTutu.ttGhpQhtIhppcGlDlSRVslGHsD.spsDls.LhchhshGsYlthDph.....Ghps.........h.s.pcRlthl+tLhDcGahc+lllSpDhpphacuhhpshhshu.......hsa....l.sslIPtL+p+GlopcsLcshLl-NPppahp	...................................................................................thsshGhTLsHEHLh.h.....s.h..u.s...hh..p........s.s..s...p..t...h.s...........................................................ph.ptshtElps...h....h.s.h.G.sco....lV-hT.s.t..s.hGRss...phltcVu.cc..T...G..lNlVuu..TG...a....Y...h...c...th...h...s...................p.t.l..t.pp.o..V.....c.p.....LAphh.lcElpp....G............I..............s..........s..........T......s......l..........+....A..Gl..I.u..E..l....usu....stl.T.h..Ec+..........shpA.AAhAp.pp.T.G...sPl....ssHs.s....hss...h..G.h..E......lc.l.......L..............p...cp.GV.c.s+...Vsl.u...H.sD...p.....pp..D..............h.....s..h..h..hc..hh..c.h..G.sa..lpFDtl.............hhp.t.......................h.hP..-.pcRl.shlttLh-c.Ga.tcpllLStDl....sp.............c....t....h....h.ts.s.s.G.hG..........asa........l.s....sFl..P.tL....t....p....p....G..ls....psp.l....c....ph.hl-NPuphhp................................................................................	0	78	132	176
+4042	PF00809	Pterin_bind	DHPS; 	Pterin binding enzyme	Bateman A	anon	Pfam-B_1411 (release 2.1) and Pfam-B_3423 (release 6.6)	Domain	This family includes a variety of pterin binding enzymes that all adopt a TIM barrel fold. The family includes dihydropteroate synthase EC:2.5.1.15 as well as a group methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) Swiss:Q46389 that catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation. It transfers the N5-methyl group from methyltetrahydrofolate (CH3-H4folate) to a cob(I)amide centre in another protein, the corrinoid iron-sulfur protein. MeTr is a member of a family of proteins that includes methionine synthase and methanogenic enzymes that activate the methyl group of methyltetra-hydromethano(or -sarcino)pterin [2].	25.50	25.50	25.70	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.29	0.70	-4.96	42	8265	2012-10-03 05:58:16	2003-04-07 12:59:11	17	42	4552	134	2104	6541	3687	202.90	28	37.28	CHANGED	llNlosDSFu-Guphhs.pt.slpp..........AcphlppGAcllDlGupuo..tP...........shlsscpEhpRllPllctltt..............sl.lSlDThcsclhctALct.GuchlNDstuhp........p.chhplstchss..slVlMHhp..................spshtpp...phc.-llp-lhphhptp.ht.h..sGls..pcllhDPGl..GF..u+s.pcshtllpplsc.........htth....shPlLlusSRKshlu	.........................................................llNls.cSFssG..u.....p.....h....h.....p......h......t..h.....s..hp.c...................................Ac.phlp..p.....GAs......lIDlGs.-us....tP..t.................s..l..s..s.c.cE...h.pRlls.....l.l.....pultp...................................clslSlDo.+scVhct...uL....c....s....G....u...c......h...lN.Dshuhp.........................p.ph..hpl..s...t.c.....h..u.s........slllMahp..........................................................p.s.....t..cs.........sph..c.................-.l..hp.....clh.p.hhtpp.h..h......sG.ls..ccIllDPu.hsF..........uts......c...c.s.h..t.l.l..p.p.l.pt.............................hpth................shs..l.l..hGsSpKthhu...................................................................................	0	718	1410	1818
+4043	PF01091	PTN_MK_C	PTN_MK; 	PTN/MK heparin-binding protein family, C-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.70	21.20	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.63	0.72	-3.99	10	216	2009-09-12 05:24:01	2003-04-07 12:59:11	13	5	76	1	107	213	1	60.10	45	38.44	CHANGED	GA-CKYcFpsWGECDusTGhKoRoGoLKKALaNA-CQpTVoloKPCsptsKsKspu...KKGcGK-	...........Gu-CKYpF..p.uWGECDssTuhKoRo.GoLK..+...uhh.sAsCpp..TlsloKPCsptsK....sK..pt.......pKtp............................	0	19	28	65
+4044	PF05196	PTN_MK_N		PTN/MK heparin-binding protein family, N-terminal domain	Finn RD	anon	Manual 	Domain	\N	20.00	20.00	22.80	22.80	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.32	0.72	-4.00	6	140	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	45	1	55	116	0	58.00	63	38.71	CHANGED	KKEKsKKshtuS-CuEWpWGsClPNStDCGhGhREGT.....Cs-pT+KlKCKlPCNWKKcF	.............KKEKscKps.tt..S-C..u.EWpWu.sCVPoSGDCGlGhREGT.....Ccpph+p.+CKIPCNWKKpF...........	1	4	9	25
+4045	PF04387	PTPLA		Protein tyrosine phosphatase-like protein, PTPLA	Mifsud, W	anon	Pfam-B_1525 (release 7.3)	Family	This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types [1].	21.20	21.20	23.80	22.00	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.17	0.71	-4.82	70	686	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	312	0	448	652	10	151.90	32	59.31	CHANGED	Qsh.AllEllHuhlGlV+Ss.lhsThh.............................QVhuRlhllaulh..hhhPpsps.......................p.shshhlluWSloElIRYuaYshsl....hshs..PthLsWLRYohFhlLYPlGls.uEhhh.................lapulsh............h...sthshuhtah.......................hhLhhhLlh.....YlPG..hhhlYsaM...ltQR+KhLtptp	.......................................................................................Qsh.AllE.....ll.H.....s.h.lGlVpos.l...hsThh.............................QVhuRlhllas.lh..t..sh...phps..................................p.slhhhlhuWols.........Ell....RYsaYshsl.............hs.hh......PthLpWL.RYohFllLY...PlGls.uEhhh.................latulsh...htt.......t.hs...h.h......P.th.sh.s.h...pah............................hh..Lhhhhhh................YlPs....h.hh.ahaM...hpQR++hlt...t..............................................	0	128	210	344
+4046	PF01242	PTPS		6-pyruvoyl tetrahydropterin synthase	Finn RD, Bateman A	anon	Prosite	Domain	6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits [1].	21.30	21.30	21.50	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.77	0.71	-4.43	149	3812	2012-10-01 20:59:24	2003-04-07 12:59:11	14	10	3101	68	1103	2685	1412	126.40	30	87.70	CHANGED	pls+c.hpFsAAHpLh.sht...............GcCpp.l..HGHsaplclplpup........hscsG...hlhDFsclKphlpp.lhp.p..hDHphL.N...-hsthtt..............................................P..TuEslAtalacpLpptl..........thpltp.lclh..E.ossshsp..ap.tp	..................h.lh+c.hpFpAAHpL...phs.........................t+Ctp.l..HGHoahVclplpGc.h....................scsG......h.lhDFuc..lK.phh+...lhc....p.......hD...HphL..N.....-h.sth..ps.....................................................................................P..TuE....slApalapplpstl................splp.p..Vplh..E.Tssshs.ap.................................................................................	0	366	700	933
+4047	PF00854	PTR2		POT family	Bateman A	anon	Pfam-B_571 (release 3.0)	Family	The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.02	0.70	-5.68	25	7665	2012-10-03 03:33:39	2003-04-07 12:59:11	16	26	2595	5	2449	6215	1113	304.30	20	67.32	CHANGED	apTIhhuullYslGhslhsluuss.sh...............s.sht..............hshhaluLhlIulGTGulKPsVSuFuuDQF-.csp...ctppspFFshFYhuINsGSLlushhsshlp........pphsasluFGlsulsMllulllFhhGpthY+ph..tss.hhhs...hlshllsshh+ptthths...ttthlhhs....hpphs................pthhppphhtsp.......sshlhhshshhhshh.....sp.spsthlptlhhhhtlh.hhhlh.sphhs.huhhhlt.lsthphhlhs.hplsssphsshsshslllhlslhshllsshsp.....hphshohhh+hulG.hhhthushhssh.................................................lph.....thssstuhsss.....hhhl.shhhhhthsplhlpusu.s.....hhh.phhhspt.shhpuhhhhhpssss	..................................................................................................h..slhhu.uhl...h.h..l...........Ghhh......h..s..h.....th....................................................................................................................hha..hu.l.h.h..l.s.lG..s.G.......hh....K...........sshushhuc....ap...tp.........................c.ph....su....hF.shaY....hu.l.NlGuhh.u.h.hsshlt.................................................................pp..hu.a.t...h..uF...s...l.s..s..h..u.hh...l..u.ll.......h.a......h..h......s..t.....t.......h.....h..........h.....t.........................s.........hp...................ht.h..h.....h...h.....h......h..h..h......h...h.........h..................................h........h..................................................................................h..h...........h.h...h.............................h.h.......h............h...................................t..p..p...h......hhhh..hh.h....h.h.....h....h....h.....hh...h..h.t....p...h...............s..t.......h.s....h..h.......h........p........s.p...........t.................................h.......h.......s...................h...........p.........l.................s.ss...h.p..s...l.sshhl...h.l....h.ssl...hshlhh..hhp..........................t.s.h..h.+.huhG.........h....h....h..hh.uh....h..h..h..hh..............................................................................................................................................................................................................................................hth...............hs...t...t..t..s....hs...................hhl.......hhhh..hsphhlssl..u.s..................hhh.phh.tt.h.s.hhuhhhhh.h..h..........................................................................................................................................................	0	540	1303	1941
+4048	PF00381	PTS-HPr		PTS HPr component phosphorylation site	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.36	0.72	-4.09	168	8181	2009-01-15 18:05:59	2003-04-07 12:59:11	14	41	3582	89	1297	4207	498	83.30	31	35.45	CHANGED	h..hp.tpl...sltsttGLHARPAuh..lVptAspF..suclplt.ps.s....ppssAKSlhulhsLustpGsplplpscGp.........DtppAlpsltpllp...st	.......................ptphhlt.sppG.LH..ARPAsh..lVpts....ppF......su-lplp...pp..s.......cpssu....K...S....lhulhs..Lu..ltp...G..splpl.p..A.c.Gs.........................D..t.ppAlpslsphhpt.t.......................	0	417	759	1033
+4049	PF01885	PTS_2-RNA	DUF60; 	RNA 2'-phosphotransferase, Tpt1 / KptA family	Enright A, Ouzounis C, Bateman A, Kerrison ND	anon	Enright A	Family	Tpt1 catalyses the last step of tRNA splicing in yeast.  It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate.  This is presumed to be followed by a transesterification step to release the RNA.\	\	\	    The first step of this reaction is similar to that catalysed by some bacterial toxins.\	       E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism [1].	20.90	20.90	21.20	22.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.26	0.71	-4.99	88	1070	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	913	1	404	881	94	168.10	38	78.73	CHANGED	sp...ppt.sclSKhLShlLRHt.spchGLplDppGal..slspLlpthpt......p..sht.h.....shpclpplVpss-KpRFplp..................................................................................................................................sstpIRAsQ...GHSlp.Vc......Lph...sspt........................PthLaHGTspcthssIhppG..Lp.MsRpaVHLoss.............................hpsuhhsG...tR+.sssVllhlDspphh.psG............hpFahSsNsVhLoc......tl	....................................p..pp.sphSKhLSalLRH.........t..Ppt........hG.........l..s..lD.pcG..as..slccLl..tthp.t..........t......shp...l..........oht.lcplVts....s-....Kp......RFshp.......................................................................................................................................................................t.s.s....tpI.R..AsQGHSh.p...Vs........h.....sptt..................................sPthLaHGTspchh.spIhp.pG..Lhth.....p.Rp.....aVHLS..ss............................................ttsAhhs.G...tR+..sssVllhlcspphh..pc..G............l.Fa.upNGVhLos.......sls...................................................	0	144	252	336
+4050	PF00358	PTS_EIIA_1		phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1	Finn RD	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.62	0.71	-4.60	14	7674	2012-10-02 20:27:15	2003-04-07 12:59:11	15	18	2590	18	868	4397	51	132.00	41	27.04	CHANGED	ssstslsoPlsG-llsLspVsDpVFuuchhGcGhAIhPosGpVhAPlcGsltplFsT+HAlGlpS-sGsEILIHlGIDTVcLcGcGFpuaVppGscVctG-hLlpFDlstlcpsuhshhoPlllTNoscassl	...........................s...plhuPl.sGcll.sLs.cVsDsVF.u.pchhG-GlAI....c...P........o.....s.....G......p.........l..h...APs.s.Gplsp..l.F.s.T.p.HAlGlp...o.....-..s....G......l.......E.......l.LlHlG.l.DTVp..L..c.....G...c........G......Fp.sh.V..p.pGpcVp.sG.shLlphDlshIcp.su.h.ssh.oPVl.lT.Ntspht..h...................................................	0	230	456	653
+4051	PF00359	PTS_EIIA_2		Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.97	0.71	-4.47	153	18510	2012-10-02 23:31:29	2003-04-07 12:59:11	17	113	3409	21	2010	9683	678	141.30	21	36.45	CHANGED	p.hhspphlhh.s..php...scpcslphh...sp..hLhcp..s.........hlpst....hhpslhpREc...hhsTsl....s..su.........lAlPHsc........t.t...lp.......cs..sl.slsphpp.sl.pa....s............tt.Vcllhhlssscsst............alp..hLsplsph.l...tspph.....hppLh...p.sps.pclhp.llppt	.........................................................................................t..hptp.lhh.sh..psp.....sppcslchh...sp..hL...h..pp...s........................hlpss.........ahpu.ll....p...R..Ep....t..hs.Thl....s........su........................lAl.P.Huc....spt.....lp.......cs...sl.sls..p....h.p..p..sl..pa...s.............t.-..spsl.p..l..lhhlusssspp............Hlp...hLspLs.ph.l....tc..c..ph.....hpp...Lh...p..sp..s....p.clhp.llt..t........................................	1	621	1143	1577
+4052	PF00367	PTS_EIIB		phosphotransferase system, EIIB	Finn RD	anon	Prosite	Domain	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.50	0.72	-4.71	138	13320	2009-01-15 18:05:59	2003-04-07 12:59:11	15	22	2535	8	1413	7412	51	34.90	43	6.63	CHANGED	AppllpslGGpcNIpslspChT.RLRlsl.....p....D..pstls	.........AtpllpulGG....p-NIs..slsp.C.h.T.RLRlsl.....p.....D..pspls..............	0	324	668	1027
+4053	PF02378	PTS_EIIC		Phosphotransferase system, EIIC 	Mian N, Bateman A	anon	Pfam-B_639 (release 5.2)	Family	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.	26.80	26.80	26.90	26.80	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.05	0.70	-5.61	55	25880	2012-10-01 19:13:17	2003-04-07 12:59:11	13	36	2821	4	2482	14149	266	300.10	17	57.49	CHANGED	tcuhhhslPlllsuulllslus.................................thhs.h..hhptsusssFshLsllhuhulAhsl..t.......sssssss.uuhluhlsh.h...hshhhh..t......................................hsshhshhhsspGhhuullsullsshlaphhhp...h.h+lPcslshhs.....uptFsslIsshhshllhuhlhthlhshhpsslhs.h....h.......hhtssshhushlhuhlhphlhhhGlHtshhsshhhtsh...........hhh....s..hh................................hh.tt.h............hhhGssGssLAhhhshhhtp+spptptlspuuls.......................shlhGIsEPl.Fuhshlhshl.hhlshllsu	............................................................................................................................puhh.hlshlls.u..G...l....llulst......................................h........................................t.h.h.t.s...h...h.....t.h....h...t....h.h..u..s...s......s......F..s....h...ls........l...l....h..uhsh..u....h....sh.........................s.ss..sh...h...s.....u..s.h.h...u.h.ls..h...h......................................................................................................................................h....h..h......h....s....s...s....Gh....huu.l.l.su.hl.uu..h....l.h...p.h.hpc..............h...cl.....P....p...s...l...s..hhh........s.h.h...ss....l....lss...h....h...s....h.h...l...h....u....h..l....h...t....h.l....h.....s..h...l..s..s.s.lt.s.............h...............ltsts....hh..u...s.h.l.h.u.hl.hth.hh.h.h...G.l.Ht.s.h.s....s.s.hh.h.hhh........................................................hh.........................................................................................................................h.h.............hh..hu....s..s..u...s....s.....lu.h...h.h...s....h....h....h....t....p..+.......p..p.....t....t....p..t..h...hs.u....uls.....................................s.h.l.h.G.lsEPh.....auhsh.shs....h..hlsshlss............................................................................................	0	606	1215	1835
+4054	PF02255	PTS_IIA		PTS system, Lactose/Cellobiose specific IIA subunit	Bateman A, Mian N	anon	Pfam-B_3710 (release 5.2)	Domain	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a  variety of metabolic and transcriptional processes.  The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilised by a centrally located metal ion [1]. Separation into subunits is thought to occur after phosphorylation. 	20.80	20.80	20.80	21.30	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-9.98	0.72	-4.12	110	4200	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	1842	38	343	1558	6	94.80	39	88.68	CHANGED	EphshplIhpuGsARStshcAlptA+pG-accA-phlppApctltcAHphQTpLIppEAsG..s+hphollhlHAQDHLMouhsh+-LspEhI....cLa+c	............lshplIhtuGsARSphhEAlpt.A.+p..G..-.F..p.pAcphlppApp.s.lhcAHcsQT.p.LlppEA..sG...s.c.h..p..lollhlHAQDHLMTohhhp-LhcElI-La+c.................	0	79	164	248
+4055	PF03714	PUD		Bacterial pullanase-associated domain	Yeats C	anon	Yeats C	Domain	Domain is found in pullanase - carbohydrate de-branching - proteins. It is found both to the N or the C terminii of of the alpha-amylase active site region. This domain contains several conserved aromatic residues that are suggestive of a carbohydrate binding function.	25.00	25.00	26.00	25.40	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.50	0.72	-3.88	39	1526	2009-01-15 18:05:59	2003-04-07 12:59:11	9	80	727	16	186	1138	23	104.40	26	14.47	CHANGED	psplplHYpR....sc..usY-sWsLWlW.s-ssssss............hs.......pshshstp-c.YGsahslpLspsspp....lGFllpps...sspD.........usD+hlsh....ptsptlWlhpGspplahsps	.................s.shhRlHYp+..........ss..usY..........-shuLWhW....s-spsssp..................tWs........tshph.stpDc.YGtYhcl..pl...s..s..s..t..sp..........lu...Fllpss..........ptps......hstD.......hpl.....c...hh.....t........shs..p...l...Wlh-sDtplYhp........................	0	48	96	146
+4057	PF03829	PTSIIA_gutA		PTS system glucitol/sorbitol-specific IIA component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	26.60	25.80	24.20	22.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.51	0.71	-4.42	35	1216	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	908	2	104	427	58	117.30	39	95.66	CHANGED	Msh.....lYpoplspIGs.Apphlp-.pMl..IlFs-sA.Ps-Lt-aChlHphs..p...hpsslpsGshlplsspsY.ITAVGslAppNLcpLGHlTlpFDG.spps-hPGolalps...ps..sslphGs..pIp	.......Mph.lYposIscIGspAp-hLs-...pMl..IhFsE.s.A.Ps-Lc-aCaIHspu.....p....hpss..lpsGsphslup.ppYslTAVGslAppNLc-LGHlTLpFDG...hs..-..s..chPGsl+..Vss.....ss....s..cIssGshl.h.................	0	31	55	83
+4058	PF03830	PTSIIB_sorb		PTS system sorbose subfamily IIB component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.70	21.70	23.30	22.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.84	0.71	-4.35	122	5348	2009-09-11 23:04:30	2003-04-07 12:59:11	10	6	1539	14	422	2069	35	149.20	34	73.55	CHANGED	pIshsRlDsRLlHGQVustWspphssspIlVlsDplA...pDclpcshlchAs.PsGlphplhslpcslcshpssp.hssp+lhllhcsPpDslcllcuGl....slcp..lNlGshphpp....G+cpls..p.slslsppDlpsh+cLppp.Glc.lplptlPs-spt...s	............IsLsRIDsRLIHGQVustWspph.ssspIlVss.DpVA.............pDslp+sll.chu.s..PsGlphplhslp..Kslc.shps.sp..h..sp.p..+lhllhcsPpDshcl.l.-.u.Gl....s.l....c.p.....l...NVG..sM.......uh..p.p......G.+p..p..ls......p.slslsccDlpshccLppp.Glc.lplptVPsDst...........................	0	108	241	337
+4059	PF03209	PUCC		PUCC protein	Mifsud W	anon	Pfam-B_2839 (release 6.5)	Family	This protein is required for high-level transcription of the PUC operon.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.31	0.70	-5.75	11	317	2012-10-03 03:33:39	2003-04-07 12:59:11	10	5	173	0	127	1156	603	383.60	31	84.17	CHANGED	TLNRVMIVELAVPAslVulMlALPhLhAPFRsLhGa+SDo+tSALGa+RsPYIWhGolh.hGGhAlMPFAlllLos..ps...tsPtWhGhhsuulAFLhlGsGlHhsQTsGLALAsDluscEsRP+VVGLhYVMLLlGhlloAlhhGhLLss...................as.u+LIpVlpGsulsshVLNllAhW+.Estp.tps.....t.cscpcPsht-AWtphs.upspAhphLhslhLGThuFsMpDVlLEPYGGpVlsLsVupTTpLTAhhuhGsLlGFhhuuhsLupGhcshphAshGshlulsuFhhllhuuhhs..s..hslFhsGshhlGhGuGlFutuTLTusMpLAstspuG...lALGAWGAsQAoAAGluhhlGGslRDllpths.........t.suhuYshVaulEhhlLllolhhhssllcsptt	.............................................................................................................................................................................................TLNRVMIl.E..LulP.Ahlsu.hh.lul...hh.h.uP..h..R.shhGatSDspt.hhGh..+R..sPa.Ihh..Gshh...h..s.G..hh....l.h....s.....h.....u..l...h...h...lu..s...................sh.h.....h...Ghh.h.usluF...l...hh...G..hGl.....p..ss.pT.shLA.....LhsDhs....s.t...c....p.R.......s.p.ll.ullas.M.......h....l..h.Gh.h..l..o......Ah.lhG...t..l..Ls.s.........................................................a.o......t..+.L....lp...V...l..p.s....su.......l....l....s....h..s....L....s.....h....l.A..lW..t.Et...+..tstts.................ttsp..p....s....Ft...p...s...h.t..phh......spsps.....tph..hhh.l...hl.us.hu.a.......h..Q.D.l...l......L......E...PY.G.Gp.l...huh..o...l...u.p.TT.p.....Ls.....A.h.h.u...s...G....s.Ll..Ghh...h....s....u....h...h....l..s.....t...t.h.s........h...p...h....s...t....h...G..s..h.h..u....hhu...h...s...h...l..l...h....u..u.hs.........s......sh.hhtsu...s..hll..Ghu.sGlaususl..os.h.M.sl..s...s...t.....s......p.....sG.......lhlGsWG....A.s....Q..AhAtGluh.h.l.GGs.l.tD.......ls..p...thss................s..sshuY.u...hVat.l..Ehhlhhs.u.lhhlh.lsht...t.........................................................................................................	1	27	64	92
+4060	PF00806	PUF		Pumilio-family RNA binding repeat	Eddy SR	anon	[1]	Repeat	Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA).  Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognise all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats.  Structures of PUF repeat proteins show they consist of a two helix structure [3,4].	21.20	18.60	21.20	18.60	21.10	18.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.47	0.73	-7.78	0.73	-4.18	50	6866	2012-10-11 20:00:59	2003-04-07 12:59:11	14	49	324	360	4462	7032	23	33.70	25	20.65	CHANGED	phpsplhpLsp.cpaGshllQ+hl-h.tstpptphlh	............splhpLsp.DpaGshVlQ.....+hl-t..ss.ppt....................	0	1426	2555	3719
+4061	PF02245	Pur_DNA_glyco		Methylpurine-DNA glycosylase (MPG)	Bateman A, Mian N	anon	Pfam-B_3352 (release 5.2)	Domain	Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.	21.00	21.00	26.40	21.00	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.20	0.71	-5.14	149	1752	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1672	8	481	1305	356	183.20	36	88.25	CHANGED	spp...Fa.spsshtlAccLLGphLlpp..t....st.lsG........pIVETEAYhG......sD.AuHuapG.pTs.........RspsMFGssGphYVYhhYGhHaChNlVstscGh.usAVLIRAlEPlp.Ghph....hp.....................tpR.h................t..................................ppLssGPG+LspALuIsts.tsGtsLss.......ss........................lhl...........sss........hss..........tp..l.ssusRIGIs....cus-hPWR.Faltussh	.....................tFh.spsshpl.A+pLLGt..hLhtp.....s...t........tt.hsG........hIVEsEAYhG......s.DtAuHuatG...pTs.........RspsMas...sGplYlYhhaGhHhhlNlVsp.s.c.G.h.spuVLIRAlEPhp.Ghph.......ht..................................................................tpRtt.........tt..........................................thpLssGPGKLspALu.Ishp.hsGtsLts...........ss..........................................lhl.............ppt....................................t.s..tp..l.hsusRIGIs.....csschPhRahlpGss................................	0	157	292	393
+4062	PF04845	PurA		PurA ssDNA and RNA-binding protein	Mifsud W	anon	Pfam-B_4535 (release 7.6)	Family	This family represents most of the length of the protein.	24.60	24.60	24.70	24.70	23.80	24.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.46	0.70	-5.23	6	296	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	121	4	173	276	3	177.70	43	73.55	CHANGED	pQELASKplcIQsKRFYLDVKQNsRGRFlKIAEVGsGG......pKSRlhLShsVAsEh+DpLucF.-aYApLu.....ppttp..pp.......................pptLKSEhllRDsRKYYlDLKENpRGRFLRIpQTshRG.........s.spcQpIALPAQGhIEFRDALscLI--YGss........p-..uELPEusslpVDNKpFaFDVGSN+aGVFhRlSEVK..ssYRNSITVPhKsWs+FscpFscYsEcM	.......................................................ppLAo+.lplQpKRFYlDVKps.+GRFlKlAElh.st..........................p+u.plhLuhssA.th+p.Lsph.chhspls..........t.t....tt.................................hLKo-hl.p-pR+YYhDLKENtRGRFLRlp....Qshs.s.....................tttppIslPAQGhlEFRDALspLl-caG....................tt....-....LP.....Eupsl....p..V..D.sK.pFaFDlGsNch.GlFlRlSEV+....ssa.RsoITlP.....h.....csWscFtphhscas-c.......................................	0	40	74	120
+4063	PF02700	PurS	UPF0062; PurC;	Phosphoribosylformylglycinamidine (FGAM) synthase	Mian N, Bateman A	anon	COG1828	Family	This family forms a component of the de novo purine biosynthesis pathway. 	21.30	21.30	21.30	21.30	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.58	0.72	-4.03	102	1833	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	1819	26	504	1114	1244	77.80	38	68.30	CHANGED	ac.scVhVoL..KsuVLDPpGpAlcpALppLGaps.VpsVRlGKhlElplpss.spppAcpplcchC-+L.LANPVIEsYch.-lpc	...........lpVpVpLKsuVLDPQGpAlpp.A.L.p.p.L....G..ast.Vpc.VRhGKhh..-lpl-s.s...st.p..tscsplcphs-cL.LANsVIEcYphcl..........	0	167	348	442
+4065	PF00855	PWWP		PWWP domain	Bateman A	anon	Bateman A	Domain	The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif [1]. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organising higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression [2].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.28	0.72	-3.78	273	2569	2012-10-02 16:56:36	2003-04-07 12:59:11	12	117	297	46	1417	2476	10	92.50	23	11.99	CHANGED	hpsG.-lVWu....K.h...cGa...P..hWPuhlhs.t......................................pt......t......t...p...........tt.........tsph.............................h....VhFFu...sp.p......a..u.....al..p..t.pp.lhsap......pt..p...............pp............h...pp.................p............p...cp..................psh...ppAlppAt...pt	.....................................................u-lVWu....K.h......cGa.........P...aWPAhl...hs.........................................................................t...t..............p.........tt............tsph.............................h..VhFFG.......sp..p..............h..u.....al..s..........p.p.lh.sap.....ppp..................p.p............h.tt..................t............p..pp....................ttappAltch...t.............................................................................................................................	0	323	550	943
+4066	PF02436	PYC_OADA		Conserved carboxylase domain	Mian N, Bateman A	anon	Pfam-B_628 (release 5.2)	Family	This domain represents a conserved region in pyruvate carboxylase  (PYC), oxaloacetate decarboxylase alpha chain (OADA), and  transcarboxylase 5s subunit. The domain is found adjacent to the  HMGL-like domain (Pfam:PF00682) and often close to the biotin_lipoyl domain (Pfam:PF00364) of biotin requiring enzymes. 	20.60	20.60	21.20	21.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.28	0.71	-4.88	139	3341	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	2687	38	837	2634	637	192.00	34	23.79	CHANGED	VhhaplPGG.hoNLtsQhcp.GhtD+hc-VhcphscVpc.lG.lshVTPoSplVGs.Alh.Vhs.......................sc.+hhshsppVhsahcG.hGpPPushscclpp+lL.ps..ccs..osRPu-hLpP.-h-plcpElpp.h............h.............sc-DlLoYsLaPpVstcFhct+pphssht.hss....................hhhshphspphp...lcl-..Gcshhlcl	........................................lhhtplPGG.....hoNLppQh+p....Ghs-+a--Vh.c.thscVpp.hG.lshVTPoSplVGs.Alh.Vhs.......................................sc..chhshscplhshhpGch.Gp.s.sus..hs.pc.Lp.p...plL..cu.........p..c..sl....Ts..R....P..............u..-....h..L..pP....-..hc..p..l...c..p-ltchh....t..t.....h......................sc-DlloaAlaPplh.....hcahct......+p......p..h....s..s.h..p....l.sp..t.............................hh....s....t....s..p.php...lplp.Gpthhlp....................................................................................................	0	304	553	729
+4067	PF03013	Pyr_excise		Pyrimidine dimer DNA glycosylase	Griffiths-Jones SR	anon	Pfam-B_1388 (release 6.4)	Domain	Pyrimidine dimer DNA glycosylases excise pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond. Pyrimidine dimers are the major UV-lesions of DNA.	22.10	22.10	22.50	22.30	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.85	0.71	-4.38	26	421	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	392	7	56	317	25	114.10	37	90.02	CHANGED	MphhppsLlscLscppLLupaREhstl..............+ssuhtpcHhTl............shhFhpp.hhLhphathlhcEMpcRG...YpsstpWhs............tpapGchsPs....hhshpclttphPhhsc+.p.Yhpps	.................Mphhpp.hhlscLscppLLupHREhsul..............+usuhs.p+hTl............shhFhtpshhLhphHthlhpEMppRG...Yps.s.p..Wh..-..................paR.uchpPs....h.shtcl.....t.p....hshhscast.Yhtt................................................	0	21	32	43
+4068	PF01948	PyrI		Aspartate carbamoyltransferase regulatory chain, allosteric domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The N-terminal domain has ferredoxin-like fold, and provides the  regulatory chain dimerisation interface.	25.00	25.00	46.80	45.80	18.50	17.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.25	0.72	-3.96	60	1268	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	1241	116	234	645	96	95.50	52	59.80	CHANGED	cpcLpVpsI+sGTVIDHIsAGcu........LpVLclLs.lp..ssstploluhNlsSp+hG+.KDIlKIEsph.Lscc-lsplALlAPpATlNII+-YcVVcKhplpl	..c.pcLpVEAIKpGTVIDHIPAphG........hKlLpLF+Ls...cocpRlTIGhNLPSsch..G+..KDlIKIENsF.......Lo--plspLALaAPpATVNhI-NY-VVpKp+.......	0	65	137	188
+4069	PF02748	PyrI_C		Aspartate carbamoyltransferase regulatory chain, metal binding domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The C-terminal metal binding domain has a rubredoxin-like fold and  provides the interface with the catalytic chain.	21.80	21.80	21.80	23.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.08	0.72	-4.53	70	1294	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	1268	116	241	677	90	51.10	47	31.64	CHANGED	cplpGl..l+CsNsNCITs..s.EPVpopFtV..hp.pshpL+CcYCE+hhscpclhp	.........-cIssV..ltCPNsNCIo+...s.EPV.s.S..s.FtV...........pcsscltLKC+YCEKcas+p.V..t.....	0	70	143	195
+4070	PF01243	Pyridox_oxidase		Pyridoxamine 5'-phosphate oxidase	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.76	0.72	-3.97	141	8674	2012-10-02 11:35:36	2003-04-07 12:59:11	15	54	3619	83	2886	8805	4127	89.20	19	47.13	CHANGED	lsp..php....phlp..p................phssLAT....ss..t-..GtPpsphhh..hhhstsp...........hhhhhsstpu......p+spsltpsPc.lulhhh.tp.........h..t.ptlp...l..pGpuchlsctp	............................................thtthlt..ps...............ps..hh.lA.T................ss......tc..........G.....p......P....p.....s.....phhh......ht..h.hstp...............................hhh..h..h...o...s..t..t.u.........................p+....s....p.p.l..........p....p......s......P....p....lu..l.......h..hh..p.................................ht.ptlp.....l.....pGp.uphlpt.....................................................	0	870	1911	2492
+4071	PF00282	Pyridoxal_deC	pyridoxal_deC; 	Pyridoxal-dependent decarboxylase conserved domain	Finn RD	anon	Prosite	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.97	0.70	-6.02	11	7254	2012-10-02 18:26:03	2003-04-07 12:59:11	14	35	3273	90	2360	6947	942	298.70	24	67.83	CHANGED	PGYL+t...hlPtsAP.csEshppIhpDhcchlhPGlopWpsPpFauaaPsssSh.uhlu-hLssuINssGFoWtsuPAsTELEhlshcWluchltLPttFhtp.t...GGGVlQsouSEusLlullAARp+hhpch+tps........huKLVsYsSDQsHsSl..cKAutlusVc...h+hl.scp..phthpspsLccAIEcDhppGhlPhaVsATlGTTsssuFDslpcluslspc......aslWlHVDAAYAGoAhICPEaRp...hhpGlEpADShshNPHKahlshhDCoslWV+-cstL.pshphss.YLppsp...shssDhtcapIshuR..+hculKlWhllRuaGlcsLpspIRcphphAphhpshlppDsR.FElss...chthuLVCFRlK	.........................................................................................................................................................................................................................t......h........................................................sh.s.....h..h.p..h.......P.t...h.s.....lE.......hhlshl.s.p.h.h.....t..h...s............................................us.Gs....hp..s.u.u.o...pus.hhu.....h....h.........s.h+......t......p.......h......h.....t......p......h...t.t...t..t..............................................htc.....s....hh.s..u.pp..s.H...h...s.h....cK...s...u....t...h....h....s...lt..........................lp....l....s....st.........pt...t.h.p...............h..t..s...l.c...p.t.....l...p....................t...........s........p......p..............h................................h.......l................l.....u...o..h..G.......oT......sG.....s.h.....D.....s.....l....p....t....l....s..s....l...t..p.c...............................h..s...l...a...lH.V......DA..A.h.u...G.....................h..........l......s......s........hp...........................h.ht.l.....p...........t.......s.c..S......lshss..HK.......ah.h.ss.....h.ssu...hh...h..h.+.p....p....h...h......p..........t..h........h...p...s........Y..L..t...................................................................................................................................................p.......h..h.......p...h.......tl...h.u.R................t...h...h...p.ha...hhc....h..G..h...p...s...htthhpp.........t...........ht.......hAthht..p.....l....t....t..................h..lh............h.s.....l..h.......................................................................................	0	695	1263	1924
+4072	PF00719	Pyrophosphatase		Inorganic pyrophosphatase	Bateman A	anon	Pfam-B_613 (release 2.1)	Domain	\N	21.90	21.90	21.90	22.00	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.63	0.71	-4.78	157	4053	2009-01-15 18:05:59	2003-04-07 12:59:11	14	17	3177	158	1242	2843	708	156.90	40	75.74	CHANGED	ssl...lEIPpsop.sKYElDKcsshhhlDR.............hhass.....htYPtNYGalPpTls......................sDGDPlDlLVlss.tshhsGsllcsRslGlLpMhD-.....uttDtKlluVsss...Dsta.p...slpclp-ls.thlppIpcFFcpYKsLc......psKhl..plpsatstctAtchIpcuhppa.pp	..........................................slIEIPtsup...hKYElDK-o.G....t...lhlDR.............hhhou......hhYP.sN.YGalPp..TLu............................tDGDPlDV.LV.ls.s...hP.l.h.P.G.s.V.l.c.s.Rsl.GlLpMtDE........ustDtKllAVPts....c.pa..s.......clcD..l...s...Dl...s....t.....hh...hppIp..HFFcpYKsL-.................tsKaV..c.l.psa.tstctApt.Ihpuhcphp.t.......................................................	0	391	752	1029
+4073	PF02547	Queuosine_synth		Queuosine biosynthesis protein	Mian N, Bateman A, Eberhardt R	anon	COGs	Family	Queuosine (Q) biosynthesis protein, or S-adenosylmethionine:tRNA -ribosyltransferase-isomerase, is required for the synthesis of the queuosine precursor (oQ). It catalyses the transfer and isomerisation of the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to form epoxyqueuosine (oQ-tRNA).  Q is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine, aspartate, histidine, and tyrosine tRNAs [1,2]. In Streptococcus gordonii , QueA has been shown to play a role in the regulation of arginine deiminase genes [3].	25.00	25.00	25.30	25.20	21.70	24.10	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.28	0.70	-5.72	110	4206	2009-09-10 15:09:34	2003-04-07 12:59:11	10	5	3721	5	867	3069	1946	327.50	45	97.57	CHANGED	pls-FDacLPpELIAQpPsp.....RcsSRLLllcpp..........ss..t....lpcpp.Fp-lschLpsGDLLVhN-T+VIPARLaGpK......t.....oG..................G+lElL......lhch......h...t...........ttt........a.s..hl+su+ch+sGsplhh..........st.......sh.....pupVltp...tpt..sth.llphphpt..........shhphLcchGc.....lPLP.PYIcR...................ts........stt...Dp.cRYQTVa..A....c..csGuVAAPTAGLHFoppLLppLppcGlphuhlTLHVGhGTFpPV+...s-clpcHpMHuEahplspcssptIpps+.tpGtRllAVGTTslRsLE.o.......A......upp.........Gt...........lpshpGcT-lFIhPG..YpF+lVDsLlTNFHLP+STLLMLVSAFuGp-plhpAYpcAlccc.......YRFaSYGDAMLIh	...................................p.lsDFcFcLP-c.L.IAphPht..................pRssuRLLl...l...ctp...................su.....p...l.p...c.p...p.FpDll-..hLp.......sGD...hLVhNsT+VlPARLaGpK..............t.......oG.............................................u+l...ElLl.+............................h...s...scp..........h.s.........hl+.......s.........u........K.............+........h.........K........sG...s...pl.hh...............s-...................................pl.pA.p.hh.tchpp........ttt....lhch.p..ass.....................h.h-lLpplGc.....hP.L.P.P.Y.I..cc...............................................t......-..t........Dp-cYQTVY......A....c...c.....G.ul..AAPTAGLHFocpLLpclcsK.GVchsalTLHVGhGTF...pP...Vc...V-slp-Hc.MHoEahplsp-ssctl..............pt...s...........K.......t.................pG.s............RllAVGT..TSl..RoLE..o....s......upp.........pst...............................................l..p..s..h.p.G..TsIFIhP..G..Ypa+l.VDuLlTNFHLPcSTLlMLVSAF..........u......G.h-.phhsAYcpAlpc.c.......YRFFSaGDAMhI.................................................	0	311	582	740
+4074	PF00788	RA		Ras association (RalGDS/AF-6) domain	SMART	anon	Alignment kindly provided by SMART	Domain	RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure [3] similar to that determined [1], and that of the RasGTP-binding domain of Raf kinase.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.91	0.72	-3.50	54	3464	2012-10-03 10:59:06	2003-04-07 12:59:11	18	281	276	21	1924	3208	3	89.70	17	10.59	CHANGED	spthl+Vahssts.............hpoltlstssospcVlpthlcKhtl.......sssppatL............hhtptstcc..........hLtss-pPlhhhhph..t.........psphhlppppp	............................................t...hl+lah..ts...s.........................hpslt..ls.pp.sTsp-..V.lptl...lp...+h...........tl..............ss......spp.asLh................................hhtt....ts...tc+.........................................hLt..s.p-psl.hhhhph................thphhlcpt..h...........................................	0	459	669	1233
+4075	PF03528	Rabaptin		Rabaptin	Griffiths-Jones SR	anon	PRINTS	Family	\N	27.20	27.20	27.40	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.52	0.72	-4.13	5	248	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	45	2	100	219	0	108.70	41	30.00	CHANGED	KAlAsVSEoTKQEAlscVpRQpQEEVASLQAIlK-Tl.......SuY....EoQasL.LcQE....................RtQhtQspEucERE.lu+L+phLucAp..DsLE+pMKKs+ELs-pL...Kpssp-hEpcI	.....................ph.uth..spcQEth.pshp.pQEEsASL.us...lp.-ul..............suY...........EsQaph.LppE...........................................ptQhtQ.pEutpR.......E....ls.cLpp.hLpcup.....-..sLEcpMc....ctQE.t-hL...+p.s.s.pppI................................................	0	9	16	42
+4076	PF02144	Rad1		Repair protein Rad1/Rec1/Rad17	Mian N, Bateman A	anon	IPR003021	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.72	0.70	-5.63	26	354	2012-10-02 11:47:48	2003-04-07 12:59:11	11	7	284	3	227	571	15	238.90	27	75.42	CHANGED	lFoAsossscpLhslLpslshhs..c..........AhlploscGl+hssE.cs+slQupsalspslFssYpa....................................................................tt.t.ptshssFplsLsslL-sLsIFGssssss..............................................................sCphsYpGpGsPLslhLE-...sslpTpCclsT...............Y-s-........-sh-lshs.csplhhclIh+uchLpsAlpELctstspplplhsos..p.............pP.......................aFtLsop.GphGp......Spl-asscps.....................................lhEpFplp..........pcshps.Ycauhlc+st+AhtlAsKVslRhDppGlLSlQhhh	....................................................................................................................................................h.u.hsssctl.phLpslt.atp...p............uhh.lopp.Glph.s.....s.E.pu..+sl.Q....upsalp.p.p.lFppaph............................................................................................ppttspFtlsLshLl-sLslFusss.st.........................................................................................................................................shphp.Y.t.u...G.tPLhlhlc-........ssls..s..p.s...plpT....................hts-......................tsh-.hs..hp..ps....s.l.h...chlhp..o.phL+cAh..p..............-Lc.s......s.p....lplhhss...p.........................tP........................hh.plps..Gt..hup.......splca...s...psps..........................................h...h....-...tFpsp................ph..s.Y+hshlc..sh.c.....Aht....hu....sK....l.tlRhstpGhLolQhh.......................................................................................................	0	86	129	188
+4077	PF03215	Rad17		Rad17 cell cycle checkpoint protein	Mifsud W	anon	Pfam-B_2764 (release 6.5)	Family	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.80	0.70	-5.82	3	406	2012-10-05 12:31:08	2003-04-07 12:59:11	10	19	278	0	287	3132	1602	329.80	21	56.41	CHANGED	lp-DcsE.WaEKYKPpstc-LAVHK+KIc-VcpWLcApsLEsp.+p...ILLIoGPSGCGKSTslKlLSKELGhplpEWlNPssh+pPsN..QcoDF+GhspspSpF.....hSQhEoFsEF.L+uo+Y.hlQhhGcshpscKKlILlEDLP..NpFatDo.+sF+pVIRpaLpSucsh..PLIhlITEh..-sLEGDNNQR+.....oFsu.pIMsKEILp-PRlosIpFNPIAPTlMKKaLspIlspEhph.tGKsKsPK+pSllEhICQuopGDIRSAINSLQFSuS.....KGppNlR.hKcG......hSLcustVL.pLSKScREu........ps.hshpspp.puhhtKDVoLuhFHAIGKVlasKRuossEl.........DSERIsu.............pLpp.pR-ph.............LVEsEsslp.StLSG-lF+LGLaENYlDFs...hoIDDAsslsDhLShuDsLSGDasos.YsLRElSToFuspGshtpN+upsYh.pphtspphps.aKsQh.......................Fhh.t.hhcpC.uhKtha..FYLPuL.shpot.h.hhshho..M+spstIshlpcI...........GhhPL................cR+a	..........................................................................tt........W.pp.a.........tPts....t-..l....s....l...p........c....K....l.....t.p.l...p.p.h..l....p................t..................h...........t......t................t..t...............................lLllp..GPsGsGKo.s.s....l.p.h....L......u....p....p......h.....s..h..p....l..........c.......h...............s..s................................................................................................................................................p...t......a...........t....h.........................................t..............................................................................................................p.............................p....l..l..L...l..-..-hP.........s.h...t.....t....t..hpt.l.p.h....h..............t....t.....................Pllhhlo...................t........................................lh....s.....p....l.....t......p.....t..ht.........l...pFNslsss.hhKhLphl...ht......p..............................................h..s..........l.p..l...st..............GDlRsAl..tsLph.s.....................................................................................................................................................................+-.sl.hF+u.lG+llaspp.........................................................................................................................................................................................pt.h..........t.....h..hl.hpN...h...................h.p.....h...h..p....hu.sD..h....................................................................................................................................................................................................................................................................................................................................................................................................................................	1	96	159	246
+4078	PF04824	Rad21_Rec8		Conserved region of Rad21 / Rec8 like protein	Kerrison ND	anon	Pfam-B_2686 (release 7.6)	Family	This family represents a conserved region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families.  Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex [1]. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation.  These proteins may also be involved in chromosome condensation.  Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation [2].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.56	0.72	-4.78	16	498	2012-10-01 19:44:35	2003-04-07 12:59:11	11	5	266	4	328	500	17	52.40	30	8.40	CHANGED	ssspt.phspls.supsR+pAA+hFaphLVLpsp..phIplcQ.pcPYu-IhlpssPsh	...............s.......hptls..psss.R+.pAAphFaphL....VLtsp..pslcl.pQ.....p.....ps.....au.cIhhp.t.....................	0	93	164	254
+4079	PF04825	Rad21_Rec8_N		N terminus of Rad21 / Rec8 like protein	Kerrison ND	anon	Pfam-B_2686 (release 7.6)	Family	This family represents a conserved N-terminal region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families.  Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex [1]. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation.  These proteins may also be involved in chromosome condensation.  Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation [2].	20.80	20.80	20.80	22.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.44	0.72	-4.11	49	651	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	292	0	433	644	1	112.00	34	17.91	CHANGED	MFaoptlLs+.cGsLuplW.........LAAphpp+.....Ls+pplhpsslsposc..........................................pIhp.............Ppss............huLRlSGpLLhGVVRlYu+KspYLlsDspcsh.+l+hshp.s.........thsh..............ttpsshsslsls	.......................................MFYsp.lLs+..pGPLuplW.........LAAp.hc..+K.......................LsKs....p...lhpssltpos.-...............................................pIlp...........................P.p.s....................hALRh..SGpLLl...........GVVR...........IYs+Ks......cYLLs.Dsscshh..+l+hsa+.s.........s.h-.ls.......t....................................................................	0	128	232	348
+4080	PF03835	Rad4		Rad4 transglutaminase-like domain	Bateman A	anon	Bateman A	Domain	\N	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.92	0.71	-4.79	41	550	2012-10-10 12:56:15	2003-04-07 12:59:11	10	22	265	6	403	698	3	136.50	22	18.13	CHANGED	pslptsphostcpppsp.................tppphtspch.hssaWsEVa...sp................tpc+WlsVDshst...........hhpph-sh...sppspps.hsYVlAass-sss+DVTpRYst.p.hsups++hRls..................tpWa......cpllp......app.pppc..................................DphE-tphp	........................................................................................sp..............................................hs.hhWsEVa.....sp................tpp+WlsV.Dshph........................................sh.pPh..........tpshp.....p...hsYVlAap.s.c...s........ss+DVTpRYsp..p.h..stsc+tRls...........................tpWh.......pp..s.lp............hpp.thpp..................................-phEp.ph..................................................................	0	105	204	338
+4081	PF04098	Rad52_Rad22		Rad52/22 family double-strand break repair protein	Aravind L	anon	Aravind L	Family	The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52 [1]. These proteins contain two helix-hairpin-helix motifs [1].	20.30	20.30	20.30	20.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.98	0.71	-4.49	35	602	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	410	33	261	527	127	137.00	28	43.84	CHANGED	chpplQspLc+.lss-alotR.GssG.p+........lsYl-uapllsLANElFGFNGWuoplhslpsc................ah-pptt.t...................+hslshsshVRlTLKDGT....a+EshGhGpspshcsKutAapKAKKEAsTDALKRALhs.FGsslGpslYD+phhtp..hsphpps..shch	...........................................................................tt.Lcp.hssE.lp.Rht...tu.u.p+............lsY....l..suctlhphhN-lFGas..GWpsplp.slss............................................................................hshsshsclo.l+...s.so...........................u...ths.....pph....cut..t.....s..........c.......A.hKtuhosuhKR.Ahhp.aG..lGphlYshp.hht..........................................................................................	0	80	143	209
+4082	PF04139	Rad9		Rad9	Wood V, Finn RD	anon	Pfam-B_28077 (release 7.3);	Family	Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage.  It contains a Bcl-2 homology domain 3 (BH3) [2].	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.50	0.70	-5.26	16	382	2012-10-02 11:47:48	2003-04-07 12:59:11	8	8	271	3	251	862	61	232.50	24	56.82	CHANGED	hu+AlpsLSRlGD-LalEsscctLsL+slNSS+SAaushhFss.FFppY.........st.sssshpC+lthKulLslFR......................uhsthptsVE+Cpltl....pspps+.......................................llhplhCKpGlpKTaplsappspsl.pAlaspspssshlphss+lLs-hlsaFspsh-ElTl...........sssp.t+..Vhl+oasE-shct.........p.cshpTplslcs.-EFcpaplstc.................scITFslKEFR...........................uhLtaAEshsssluhaFspsG+Phhho....hs..c.phlEupFlLATl	.........................................tcsl.sLu+h.ucpl.lp..s..............t.....p....t.......LtlpslNso..+SuasphhF.t......FF.ppa.................................tt..ttt...h..p.Cp.l.h..K.u.hh.s..lF+....................................................................................s.t...ppsl-psplpl.................pspps.+..............................................................................l.h.hph.h...s...c......p.G....l...h..K....o.....a.....pl..s.h..............p..................ts......p.....sh..p.................s................hh................s.p...p....t..t...s........s.h.....h.t...hps............+..hLtch.lt..pF..ss.....s...h.....p..-lsl...................................thss..pp.......l.hp....s..at...cp...h...st..............................................p.pshtTphs....l.s....c-....F..p..pa...plttp.............................................hplsF.slK-h+...........................uh...ls...a......u-......s..h..p........h.......s.............ls........hhas.tsGcPhhhs.....hp......p...hpsphllhT.....................................................................................................................	1	84	135	195
+4083	PF04002	RadC	RadC; DUF2466;	RadC-like JAB domain	Kerrison ND, Finn RD, Iyer LM, Zhang D, Aravind L	anon	COG2003	Family	A family of proteins present widely across the bacteria. This family was named initially with reference to the E. coli radC102 mutation which suggested that RadC was involved in repair of DNA lesions [1]. However the relevant mutation has subsequently been shown to be in recG, where radC is in fact an allele of recG [2]. In addition, a personal communication from Claverys, J-P, et al, indicates a total failure of all attempts to characterise a radiation-related function for RadC in Streptococcus pneumoniae, suggesting that it is not involved in repair of DNA lesions, in recombination during transformation, in gene conversion, nor in mismatch repair. Computational analysis, however, provides a possible function. The RadC-like family belong to the JAB superfamily  of metalloproteins [3]. The domain shows fusions to an N-terminal  Helix-hairpin-Helix (HhH) domain in most instances. Other domain combinations include fusions to the anti-restriction module ArdC, the DinG/RAD3-like superfamily II helicases and the DNAG-like primase. In some bacteria, closely related DinG/Rad3- like superfamily II helicases are fused to a 3'-5' exonuclease in the  same position as the RadC-like JAB domain. These conserved domain  associations lead to the hypothesis that the RadC-like JAB domains  might function as a nuclease [3].	20.60	20.60	20.60	20.60	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.13	0.71	-4.43	107	5120	2012-10-10 14:49:21	2003-04-07 12:59:11	10	20	3434	8	980	3486	385	118.30	39	57.04	CHANGED	tlsssp...plhphlp...plt.....stpp....EphhllhLsspspllthpplsp...GolspshVpPRElh+pA.lptsAsulIlsHNHPSGsspPSppDhplT....c+ltpAspllsIpllDHlIl.u.......pspahS.ht-p.Ghl	................................................................h.hposptstcalt.....phs.....s.h.p.p.........EtFhlLaLsspsplIt.tcp.l....Fp....G.Tls...ps.V...a.PR....E....ll...+pA.lp.t.sAuu...l.ILsHNHPS..........Gs..s......p....P..S..psDhtlT....c+lhcAspllsIclLDHlIl..G...........ps.p.hhS.atEcGh.......................	0	330	632	813
+4084	PF04712	Radial_spoke		Radial spokehead-like protein	Mifsud W	anon	Pfam-B_5891 (release 7.5)	Family	This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene [1].	22.70	22.70	22.90	22.70	22.10	22.50	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.60	0.70	-5.75	22	369	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	118	0	235	361	8	295.50	22	75.46	CHANGED	hptplpps...+AaL..ppsspsshsLY-HLsplLs+llc-cPps.uhDl..hEshStpl+pspa............tppcs.ts..phtsshchspppppLFtpst...............................p.p.............tcthscs.lssl...............hpt.shaappuGlGLuc-Esa+lhhAlKpLsc...pcslpssRFWGKIhGhptsYalAEsp..hccsEcptc.tt.t.t.t..ph..t.ttt.................................................lPhEtsts.....GsN+asYaVsspsu.s.sWs+LPsVTPtQIhsuRpI++hFTGcL-AsVho.aPsFs.............GsEtsYLRAQIARISuuTpluPhGh...Y..............phpE-Et.ttppt.tt.p............ph.csP-acslps............ph...phssWVHhhtaILsQGRssah...........tpptE-c...............-E-c-ccc--.cEs............c.EhGssLLsslscD................................................t.tlsst.......ssWoh+hsu.shhs..................paulsVl+SthWPGAashu..s....u++apslYlGaGhKhssp.sasP.....s.PPPstpEass....lsEhpDPos-EEtthch......sp-psp	................................................................................................................................................h............................................................................................................................................................................................................................hht.sGhsls.pc.h...l.hulh.l.p...p....h..tphhFWG+lhGhp..tsYhlsps........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..c...................................................................................................................................................W................................thhhhps.hW.Ghhhh............tt........h..hYhG.G.p.......................................................................h........................................................	0	110	129	177
+4085	PF03089	RAG2		Recombination activating protein 2	Griffiths-Jones SR	anon	Pfam-B_4702 (release 6.5)	Family	V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity  is generated from a limited amount of genetic material.  This  process is synergistically activated by RAG1 and RAG2 in  developing lymphocytes.  Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.	19.40	19.40	19.40	19.60	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.13	0.70	-5.72	18	5792	2012-10-05 17:30:42	2003-04-07 12:59:11	9	5	4451	0	28	5451	1	268.30	58	91.61	CHANGED	KpsELKLRPloFSNDSCYLPPLRpPAlspl.ssp-u-sppYLIHGG+TPNNELSspLYlhohsS+u.NKKsoLsCpEKELsGDlPcuRYGHTlsVVaSRGKohsVlFGGRSYhPsGQRTTEsWNSVVDC.PpVFLlDLEFGCCTSahLPELpDGhSFHVSlARsDsVYlLGGHoLpossRPPpLa+LKVDL.LGSPsloCTlLsuGlSlSSAIVTQsus..cEFlIlGGYpS-sQKRh.CNolsL-DssIcIppREsP-WTu-IKHSKTWFGusMGpGuVLlGIPu-sKptssDup.aFYhlsFtp-c-t.....stQsCSQEST.pD.EDSsPLEDSEEFYFupE	.........................................................ts.....pYlIHGG+TPNNElSsplYlhohss+s..N+KlThpCpEK-LVG-lPtARYGHolsVVaSRGKohsVlFGGRSYhPsupRTTEpWNSVlDC.PpVFLlDhEFGCsouahLPELpDG.SFHlulARpDslYhLGGHSLssssRPPpLaRl+V-L.LGSPsl..oCsl.L.ssGlSlSSAIl.Tps.....u.....s........cEal.IlGGYpSDsQKRM.CshlsL--stIchp.hEsPcW..TsDIpHS+hWFGushGpGshLlulPstsp....s-s..ahY.lpht......t.............................................................	1	2	4	11
+4086	PF04901	RAMP		Receptor activity modifying family 	Finn RD	anon	Pfam-B_5615 (release 7.6)	Family	The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying  protein or RAMP. RAMPs are single-transmembrane-domain proteins [1]. 	20.40	20.40	20.70	21.50	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.45	0.71	-4.33	19	191	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	42	22	86	148	0	108.10	39	71.27	CHANGED	tthtphChppFpccMcsls.phWCsWsphhp.YppLosCTchhAchlsCaWPNshs-cFhhtlHppaFpNColsththpDPPsslLhshIllPIhlTlhhsuLVVWRSKco-uhs	............................hh...phChptFptpMppls..ptWCsWs.ph....h...t..YppLopCTchhAptlsCaWPN..shs-pFh.htl.HppaFpNCs...l.s.th.thpDPPsslLhshIllPlhlThhh.suLVVW+SKcs-s.h......................	1	9	17	37
+4087	PF00638	Ran_BP1		RanBP1 domain	Bateman A	anon	Prosite	Family	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.41	0.71	-4.07	8	1512	2012-10-04 00:02:25	2003-04-07 12:59:11	13	83	333	19	988	1495	10	115.30	30	23.31	CHANGED	EVKoGEEDEEsLFppRAKLaRFDs-s..ppWKERGlG-lKILKpKcs.sKlRlLMRRDplLKlCANHhIossMpL.KPhsGS-RualWts.uDaADu-uKsEpLAlRFKspEsA-pFKppFEEuppt	......................................ltTGE.E..s..E.c.slap.h.+.uK..L.a..ca..............s.....p....ps...............pp..W.....K....ERGhGsl.+..l......L.............c.............p......p.........p......s.....t.........p..........s.........R.llM..R.p-..........p.s.....h.............+...lh..hNphl...hs...s...h.pl....p......t.........ss..p...................c...u.hh.a........ts......hD......h..u...-..t...p....s...c...................s..............pp..h..sl+h....ts....t.-......Apphtphhpch.................................................................	0	331	490	762
+4088	PF03085	RAP-1		Rhoptry-associated protein 1 (RAP-1)	Mifsud W	anon	Pfam-B_1750 (release 6.4)	Family	Members of this family are found in Babesia species. Though not in this Pfam family, rhoptry-associated proteins are also found in Plasmodium falciparum. Indeed, animal infection with Babesia may produce a pattern similar to human malaria [4]. Rhoptry organelles form part of the apical complex in apicomplexan parasites. Rhoptry-associated proteins are antigenic, and generate partially protective immune responses in infected mammals. Thus RAPs are among the targeted vaccine antigens for babesial (and malarial) parasites. However, RAP-1 proteins are encoded by by a multigene family; thus RAP-1 proteins are polymorphic, with  B and T cell epitopes that are conserved among strains, but not across species [1,2,5]. Antibodies to Babesia RAP-1 may also be helpful in the  serological detection of Babesia infections [3].	25.00	25.00	55.30	48.50	22.00	18.70	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.76	0.70	-5.03	12	102	2009-09-11 11:32:32	2003-04-07 12:59:11	10	3	9	0	17	101	0	195.70	39	57.46	CHANGED	scoLtssspshpsttpppchspsMpp.hs.hssphh-tlCptshcp.spC+ptVssYVsRCpptsCholDshpashptp.psLsLPsPYQL-AAFhlF+pssusPh+pthcphhhRF+psupausY+pFlhsLLp+N...hhhcssssD..l-shls+YhYMsTlYYKTYLsl-phpu+hhN+hsFs+alFuhtI++ALppIl+sNlPccht.chslsclpplssuYtpYhh.sQlPshspFApcFupMVhcsLlpolu	....................................................hpttMt..h...tp...tphCpts.tt.ppCtt.ltsYhpRCtt..hsChTlDshph....t.psLsLPs.aQL-AAFhLF+pSsuN.t+pthcp.hh..........Rh+t...ttpasta+pFlhsLhppN...hhp.p.tssD..l-.thsspahYMsTlaY.KTYL...sls.hsAKhhN+huaopclFuh.tIppsLppll+.NlP.sht.phs.tplpplssuYtpYhh.oQlPshspFAccauphshcsLl.sls................................................................................	0	2	10	10
+4089	PF00071	Ras	ras; 	Ras family	Sonnhammer ELL, Fenech M	anon	Swissprot	Domain	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head.  See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.79	0.71	-4.85	61	21243	2012-10-05 12:31:08	2003-04-07 12:59:11	17	332	1006	663	12839	30754	3385	151.90	29	62.64	CHANGED	KllllGDuGVGKSsLllpFspspFsppa.sTIth-.....Fhp+plplD..........ucplcLpIWDTAGQEcacslpstYYRsupGhllVYslTscpSFpplp.pWhp-lpchss..........pslshlLVGNKsDLcp.................................pRtVstpcupphA.......cchs.lhFhETSAKsshNVccsFhpls+plhp	.........................................................................KllllG.c.u........u.V.G...K........o....s........L............l...............h...........p.............a..............s.................p..............s...............p..........F..............s...........p............p........h.........................s........T.........l..................h..-..........................h..h...t....p......p...l...p....l..s.......................................s.p..p...l....p..L........p....l.........W................D.............T.........A..................G............Q............E.............c..........a.............p............s..........l...........p..............s...........h................a...........a.................+...............s................u..............p.....u....h.......l.......l.......l.........a....s................l....................o...........s............p.........p..............S..........F..........p.......s............l.............p......p..........W...h...p....c...l.p..p....h.ss...............................ts.h...s..h..l.L....l.......G...N.....K....s......D....L...p.p......................................................................................................................p.+.......V...s.....t......p.....p.....u.....p.....t....h..A.....................c...p...h.......s.....h...............a........h...........E.....s...S...A..p...s.........s..........s.....l...c...p....s...F..phhpth..t.....................................................................................................................................	0	4857	6747	9773
+4090	PF00616	RasGAP		GTPase-activator protein for Ras-like GTPase	Ponting C, Schultz J, Bork P	anon	SMART	Family	All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.30	0.71	-4.65	115	1769	2012-10-03 21:54:49	2003-04-07 12:59:11	14	106	254	6	1114	1705	9	183.90	26	14.50	CHANGED	hlppllp...pEl........................pp.ssp...sslh.R..uNohso+.hlspah+t.....hGppYLcpsLtsh....lpcl.h..ppchsh..ElDPtcl.................................................................................................................................................sppphp........pshppL...tphspphhssIhs.Sh.sp....h.Phsl+hlsppltpplpp+a...t.................................pth..hpsluuFlFLR..FhsP..AI......ls.Pchaslh....p....ts.stptpRsLhhluKll.QslAs	.............................................................................................................................................................................................hpphhp....tEl.............................pp...ssp...pplh..R.uN.ohso+.hhppah+h...........hGppYLpps.L..tsh.......................lppl.h........cpch....sh.El.D.Ps+l................................................................................................................................................................................................................................................................................ppplp......................psh.ppL...hthspphhssIhs..Sh..sp......h.Ph....tlRhlhpp.....lpptspp+.a.t...................................................................................p.h......hphluuhl.FLR..FlsP.AI............ls..Pchaslh......p....................p..sspspRsLs...hlAKhlQslAs................................................................................................................	0	379	541	819
+4091	PF03836	RasGAP_C		RasGAP C-terminus	Griffiths-Jones SR	anon	PRODOM	Family	\N	22.10	22.10	22.50	22.50	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.45	0.71	-4.50	38	469	2009-01-15 18:05:59	2003-04-07 12:59:11	10	30	217	6	318	442	1	133.50	33	10.26	CHANGED	shtchKpcslcslpcLEphGhlspp.NpYQp......llspIAp-I+sppphRppcppElctlppohpsLpc+spaLppQlcpYpsYlcsshtslptptp...................tpthhth+php+p.s+t.chGsaKaoAppLtccGVllchp..s.ptp	..............................htcpKp+hhcsLp.pLE..phGh.....lspp.spYQp......lls-IApDI+spcphR..ppRptELtpLppThpsLscKssahppQlchYcsYIcsshs....sLppptt..........................h.t.pthpcp.s.+tp+hsshKYoAtpLp-K.GVLlchpshp..t........................	0	97	155	240
+4092	PF00617	RasGEF		RasGEF domain	Ponting C, Schultz J, Bork P	anon	SMART	Family	Guanine nucleotide exchange factor for Ras-like small GTPases.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.16	0.71	-4.57	148	3434	2009-09-12 23:24:09	2003-04-07 12:59:11	14	184	292	23	1986	3165	4	186.00	25	19.95	CHANGED	hshsst-lAcQLTll-h...cl....app....Ip.....................pE..............................hl..spta.......sp...pp.............................ss.s......lpthlpphNplopaVsspIltp.p.............shccRspllp+aIclA...........p....................p.hcplpNasohhAI.luuLssssltRLcpTWptlspcth...c............h.hpcLppl............h............................ssp..................pNapsY..R.....ptlp...................................ps.....Ps.....................lPalGlaLp..........................DLsalpcu...ss...................shlps............................................llNFpKh..pp	........................................................................h..hsshclApQLThh-h...pl......Fpp....lp..................................................pE..............................hl..t.t.h.a......pp.............pp...t.......................................................................ss.s.........l.pthlppa.Nplo.....h.a...Vs..spIltp..t.....................shppRs.p.l.lp+.a.IclA..p..........................................c..h.p..p...lp..NasohhAI.l..uuLs..s...s..s..l...t.....R.L........c....p.T....Wp..........p.......l.spc.p........p.....................h..hp....pLp..p.l.....................h..................................................................ss.p..................pN..ap...ph....R.......phlp..................................................................phps....ss..............................lP.a......h..........u.........l.h.Lp..........................Dlhhlcpu....s.................sh.h.tt....................................................................................hlNapKh...................................................................................................................	1	658	907	1382
+4093	PF00618	RasGEF_N	RasGEFN; 	RasGEF N-terminal motif	Ponting C, Schultz J, Bork P	anon	SMART	Domain	A subset of guanine nucleotide exchange factor for Ras-like small  GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.	28.30	28.30	28.30	28.30	28.20	28.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.50	0.72	-3.92	88	2431	2012-10-02 12:00:53	2003-04-07 12:59:11	15	132	260	14	1433	2250	2	105.10	21	10.42	CHANGED	plpuuolp..tLl-tLssp.ph........c..sahpsFlhoa+sFs.ostclhphLhpRa............................h.ssstph.ptt..............................................................hph..+...lhpllppWlppaht...-......apps...............hlpplhpa	............................................ltuuoh-cLlp+Ls.pp...phh...........................-s.salp.sFLhTaR.....sFh.o.s..........pc.Llpt.L..l.p..pa.............................................................................................................................tstt..ptt...........................................................................................................................................................................................hph....+...lhpllp.tWlppa.....-...........Fpts.........hht.h...............................................................................................................................................................	0	411	620	975
+4094	PF01858	RB_A		Retinoblastoma-associated protein A domain	Bateman A	anon	Swiss-Prot	Domain	This domain has the cyclin fold [1] as predicted [2].	25.00	25.00	25.50	26.70	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.50	0.71	-4.64	7	366	2012-10-03 00:42:12	2003-04-07 12:59:11	12	10	157	16	185	368	1	188.10	38	21.11	CHANGED	TPVpoAhsolppLpshlsuh.spPSppLpphhpsCsps.ppslhcRlptlhEhhhpphs.u.ct...........s.phAppRhphA.pLYY+VLEshhpuEtcpLss.shosLLspch....FHcoLlACslElVhtoYps.........s.hpFPalLEshslpsF-F.KVIEsFIRp...EssLsREhlKHLNSlEEplLESLAWppsSsla-hl	..........................................TPV.ssAhpolppLps.hlsu..h..ts.tP.S..ppL.ph..hp.s.Csps.......P...pp...s...l.h..........pRlcplhchappp.hs.....t.s.sttt.................................shphu.ppR...hphAt.tL...YY+lLE..sllppEp.c..................R....L...s.....s..t...................s....h.otLL....p.p.-h....FHpSLlACsLElVhhoYps.....................s.hsFPall-lh.slss....Fc....F...aKVIEsFI.Rs..............Ess..L.sR...-hlKHLsplEEplLESlAWppsSsLaphl............	0	49	77	127
+4095	PF01857	RB_B		Retinoblastoma-associated protein B domain	Bateman A, Griffiths-Jones SR	anon	Swiss-Prot	Domain	The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain [1].  The B domain has a cyclin fold. 	20.70	20.70	22.20	21.10	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.86	0.71	-4.66	6	352	2012-10-03 00:42:12	2003-04-07 12:59:11	15	10	158	15	185	360	5	140.60	39	15.49	CHANGED	soLslFa+KVY+LAulRlpsLCp+L.s..........lp-cLccpIWshFcaoLspps-LMhDRHLDQllhCAhYshAKVsp..-hoFp-IhpsYRsQPQApspVaRSVhIct.........p...p............................h..pchsDIIsFYNplalsplKs	...............................................oLslFa+K.l...Y+LAulRLps....LCt.+L.s.............................ls.s.-..lc..cpI.WT.hFcao.L..p.p.s..-L.MhDRHLDQllhCuhYshs.K....Vs..p..............-.h.oFppIhpsY.R...p..Q....P.Qu............psp.V...a.RsVLlcp.........................................................................................pchsDlIpFYNplal.plK............................................	0	53	81	127
+4096	PF02196	RBD		Raf-like Ras-binding domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	25.70	25.70	25.70	25.90	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.09	0.72	-4.22	10	710	2012-10-03 10:59:06	2003-04-07 12:59:11	10	34	96	14	293	599	0	70.50	30	9.82	CHANGED	phhpVaLPssQpolVtVRsGhol+DsLppslcpRGLssssstVhhht......t+csLshcsctuhLsu.cElhlEhh	....................hhplhLPspppsll.ssRs...Ghol...c-sLpthlcp+G....Ls.p..sssVahht.......pccslshspsh..s...Lsu.c-lhlEhh.....................	0	45	68	156
+4097	PF02033	RBFA		Ribosome-binding factor A	Mian N, Bateman A	anon	IPR000238	Family	\N	25.00	25.00	26.10	25.40	24.90	23.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.07	0.72	-4.00	183	4543	2009-09-13 23:02:53	2003-04-07 12:59:11	13	5	4463	8	1061	2620	2217	105.00	34	77.59	CHANGED	RspRlu...pplp+plupllp..pp.l+..DPRl.........shlolocVclSsDLphAcVal...ol....h........................sp....................ppt..cpshpsLppAsGalRpplucplp..lRhsPcLpFhhD...p....ol-put+lspLl	..........................RspRlupplp+Elupllp....cc..l+........DPRl..............thlTl..ocVclosDLphA+Val...oh..l..s.......................sp...................ppt...cpsh.puLp.c.Ap..GhlRppLG+p.lc..LRhsP-LpFhh..Dp.Slchut+lspLl.........................	0	369	692	897
+4098	PF05025	RbsD_FucU		RbsD / FucU transport protein family	Moxon SJ, Bateman A	anon	Pfam-B_4828 (release 7.6)	Family	The Escherichia coli high-affinity ribose-transport system consists of six proteins encoded by the rbs operon (rbsD, rbsA, rbsC, rbsB, rbsK and rbsR). Of the six components, RbsD is the only one whose function is unknown although it is thought that it somehow plays a critical role in  PtsG-mediated ribose transport [1]. This family also includes FucU a protein from the fucose biosynthesis operon that is presumably also involved in fucose transport by similarity to RbsD.	25.00	25.00	27.90	30.40	24.60	23.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.74	0.71	-3.87	133	2765	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	2076	86	395	1291	399	134.10	35	98.06	CHANGED	MpcsslLNs-L.pllAshGHsDpllIuDAshPh....s.tspplcLslphsssshhplLcslLsph.l-phlhupphthp....ss...thhsslhpth.........ttsh.lphls+ppF.hcp.s+p..upAllpTGEpssYuNlILpsGVlh	........h+hsslLss-l.plluchGHsDpl.......ll...sDAs........hPh..........s.ts.ttlclslpt.sssshhplLpsllsphpl-s..hh....hA.pphhtp........ss...ph.ht.plhpchtt..............t.tssshpIphl.sH...p...pF.ccp.spc.......upAll.RTGEsosYu.NIILpsGVs......................	0	101	207	293
+4099	PF02341	RcbX		RbcX protein	Bashton M, Bateman A	anon	Pfam-B_948 (release 5.2)	Family	The RBCX protein has been identified as having a possible  chaperone-like function [1].  The rbcX gene is juxtaposed to and cotranscribed with rbcL and rbcS encoding RuBisCO in Anabaena sp. CA [2]. RbcX has been shown to possess a chaperone-like  function assisting correct folding of RuBisCO in E. coli expression  studies and is needed for RuBisCO to reach its maximal activity [2].	21.00	21.00	22.40	21.70	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.37	0.72	-3.93	16	676	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	573	77	69	329	10	109.20	67	78.97	CHANGED	M-lKpIAKDTAKsLtSYLTYQAVRsVhsQLuETNPshAlWLppFSuptpIQDGEuYLctLhpEsp-LuhRIMTVREHLAc-VsDaLPEMVRsuIQQuNhEHRRQhLERlTQ	.........................................MsLKQIAKDTAKTLQSYLTYQALRTVLAQ.LG........ET........N......P.P....L..u..hW.....LpNFSu..GKI.Q.DG.EuYIEpLhtE...K....s....D.L...ALRI..MTV.REHI.A.p....E.l....s..E.F..LP..EMVpTGIQQANMEQRRQHLERITp...............................................	0	18	48	64
+4100	PF00415	RCC1		Regulator of chromosome condensation (RCC1) repeat	Finn RD	anon	Prosite	Repeat	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.40	0.72	-3.75	104	14888	2012-10-05 17:30:42	2003-04-07 12:59:11	13	606	566	106	9774	17535	3239	51.30	29	20.18	CHANGED	cGplasWG..psptGQLG..............tssppspthPph..lphhps..............lhplu.sGspHohsl	......................GplasW......G............ps....s..........h.....G.Q.....LG.....................................................tss...p..p...s...p...h....t..P..ph.........l..p...s..hps.................................tlh..p..lu...s..G..s...t.Hohsl.......................................................	0	3249	5152	7453
+4101	PF04381	RdgC		Putative exonuclease, RdgC	Kerrison ND	anon	COG2960	Family	Members of the RdgC family may have exonuclease activity. RdgC is required for efficient pilin variation in Neisseria gonorrhoeae, suggesting that it may be involved in recombination reactions [1]. In Escherichia coli, RdgC is required for growth in recombination-deficient exonuclease-depleted strains.  Under these conditions, RdgC may act as an exonuclease to remove collapsed replication forks, in the absence of the normal repair mechanisms [2].	25.00	25.00	28.60	28.30	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.78	0.70	-5.46	71	1392	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	1234	4	260	909	119	288.20	47	96.62	CHANGED	MW..FKNLhlYRhscshshss-pL-cpLsptsFpPCuup-hpphGWlsPhucpsp..LsHssssplLlsh++E-KlLPuuVl+ctlcc+lpplEtcpuR+lt+KE+cpLK--lhppLLPRAFo+pppThuaIDsppshllVDuuSsp+AE-lluhLR+o.lG.SLPls..PlpsppsPsssMTpWLtps.psPssapls-EsEL+us.t-cuuhlRsKpp-Lpu-...EIpsHlpuG.KhVo+LALsWp-+lsFlLs.....--hslKRlKFtDhlpEps--h.sp-Dhst+hDADFsLMosELsphlspLlpshGGppp	...............................................hWFKNLhlYRL..s+-ls......h.....p.u.-p...hEcpLuphsFoPC...G..S.Q.D..h.s+.hGWV...s...P..hG...p..p....u.-h....L....s....H...su....s.s..pll..lsA+..KEEKlLPusVIK..pt....Lc....t.Kl....t.c....l.E....s...-..p...u.R.K.L...+KpEK-sLKD-Vlc...sLLPRAFS+hopThhaIDsssGLIhVDs.ASuK+AEDsLALLRKo..LG....SLPVV.......PLs...h...cs...s....p......hsLT-WlcsG..sss...p....G.....FpL..h-E...AELKuh...hE-.G.ulI.RsK+.QD.Ls..u-...E.ItsHI-.AG.KlVTKLAL...s..W....p......p...RlpFVhs.....-DholKRLKFsD.pL+-QN..-Dl..scED.hApRFDADFhLMouELusLlpsLl-uLGGEt.p.........................................	0	53	130	207
+4102	PF05183	RdRP		RNA dependent RNA polymerase	Wood V, Bateman A	anon	Pfam-B_2226 (release 7.7)	Family	This family of proteins are eukaryotic RNA dependent RNA polymerases. These proteins are involved in post transcriptional gene silencing where they are thought to amplify dsRNA templates.	20.80	20.80	21.00	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	580	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-13.05	0.70	-5.82	94	667	2009-01-15 18:05:59	2003-04-07 12:59:11	7	26	187	3	486	719	5	486.90	23	46.88	CHANGED	splhhpssphphss+lhRc.................a.t.pp.....Flclpas-cphpthh.t...........................hpphtphhtpulhl..........s.htapa..hs.stpt...............h+ppssahhsss.........................hshpphhphh.sshpp................sKhhuR.....hu.shosohs........lphpph.............phlsDl........................................................ttpth..........shoDGs...GhlS.slsctl...tppls.............................................................................htthPoshQ..hRh..................sG.sKGllh.l....s.ph.........................hlhlRt.ShhKa.................psthpsl.....................-lhphup..................p.shLN....................cphlhlLpphGl....pc.........hFhph.pptlpphtp..hhts....pthhphhpphtp.s.hth................................................................hhttuh..........tppsalpphlpthhppplpphpp.....+h+I.lsputhh..hGlhD.t.................Gh.....Lc..........sclalt.............................................tsttp.phlpG..pllls......RsPshpPuDlph..lcA.............lth....st............Lpp.h....pslllFss....pGt.................................pshss.huG..uDh.DGDtah...lh.......WD.pl............hs.tshp................................hphpphtcahhp.....hpsshlGhhsstahths..........................shhsspshpLuphhutslDhsK.sGh.hp.....h.p..................ht.pthPcahp.......................pptt.....................sppllsplacphtptttttttp	.........................................................................................................................................................................h.s..ht.ssphhRp...a.t.tp......hlclp.h.ptt...h......................................................................hhpphhthhtp.uh.h...........stphap..a..hs.stst.........................................h+ppt.s..ahhs...............................................................hph.t.thhphh..sphpp..........................sKhhuR........hu.shSpoh..........lt.pph..................h.Dl........................................................................................tttth......................haoDGh...GhlS.thsptl..hptht.............................................................ht..PoshQ..hRh.......................sG.hKGhlh..l.....................s.p...................t..........................l.lR...S..Ka....................................ttptttl...................................................................................-lh..p..hup....................shLN...........................pphl..lLpp..hu.l........pp............hh.ph.pp..lpphtt....hh.s.............ttshphhpt....t...t................................................................................................hh..Gh............ppsalpthl.phhht.tl...............tth..pt.......+h+I...ls..p..uhhh...hGshD.h......................sh.....Lp............................splalph..............................................tttt..h.ltG.......llls......+sPshhPGDlph..h.pA.........................................................V.h..........st..................Lpp..h....hsslVFsp....pGt...............................................................+shss..huG..uDlDGD.ah..lh.........WD.pl......................h......shp...........................................................t.pph.pahhp....................h.ps.lGhhsph+..hhs................p..........th.s..shpLuphhu......sV..DhsK..oGh.sp....h.t........................h.Pcaht..................................t...........................................utplls.lh..h.........t.....................................................................................................................................................................................................................................................................................................................................................................................................................................	0	210	321	430
+4103	PF00154	RecA	recA; 	recA bacterial DNA recombination protein	Sonnhammer ELL	anon	Prosite	Family	RecA is a DNA-dependent ATPase and functions in DNA repair systems.  RecA protein catalyses an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.95	0.70	-5.37	28	12149	2012-10-05 12:31:08	2003-04-07 12:59:11	16	16	9034	84	1090	10099	5077	240.80	66	92.66	CHANGED	KALssALuQIEKpFGKGolM+LG-cs.t.cl-slSTGSLuLDlALGlGGlP+GRIlEIYGPESSGKTTLsLHsIAEsQKpGGssAFIDAEHALDPtYApKLGVclDsLLlSQPDsGEQALEIsDtLVRSGAVDllVVDSVAALsPKAEIEGEMGDuHVGLQARLMSQALRKLTGsls+SNThlIFINQIR.KIGVM.FG.sPETTTGGsALKFYASVRLDIRRhuslKcus....chlGscT+VKVVKNKVAPPF+pAEFDIhYGEGIS+hGEllDLGVchsllcKSGAWYSYpsc+IGQG+ENA+paL+-sP-lusEIEpplRpphsh	...................................................................................................................................s.lM..+.h..G..p.t..t.......pl.p.s.......l.uTG.SL.......uLDl..A.L.......G...........l.........GGLP+.G....Rl..lEI.Y.....G.P.E.S..S.GK.T....T..L....s....L.p..s...I....A......p............u......Q...........K................p..........G....G........h................s...A...F..I....DA......E........H.....A........L..........D............P........h.........Y......A.........c..........K....L..........G........V.............s............l.........D..........s...................L..........L.........l...S.......Q.........P...........D...........T............G.......E....Q.......A..........L.......E....I........s.........D.......s....L........V.....R.......S.....G..A.........l......D........l....l.VlD.SV.AA..L..s....P..K...A..........E.....I..E....G..E..MG..D...........S.p.s......G...L..Q..A...R..LM..S..QA..LR.....KLTu....slp.pos.s.....h.s....I.FINQl.R.........K....l......G......V...M....F.....G....s...P...E..T..T..s..GGpALKFYuo..lRh...-......lR.......p........t......t........lK...t.tt............t.h.G.ps+h+lhKs+hs....................................................................................................................................................................................................................................................................................................................................................................................	1	379	738	938
+4104	PF02565	RecO_C	RecO;	Recombination protein O C terminal	Mian N, Bateman A	anon	COGs	Family	Recombination protein O (RecO) is involved in DNA repair and Pfam:PF00470 pathway recombination.	20.50	20.50	20.70	20.50	20.40	20.40	hmmbuild  -o /dev/null --hand HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.54	0.71	-4.24	157	3973	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	3952	7	846	2634	1633	151.60	18	61.19	CHANGED	ht-htthshutalsELlpthl..-pcsp.sp..LaphhhtsLp.tL.....spps......s....hhhhh.FElpLLphhGas.slspCstsGpp.s.shh..h......................ttpsspsttshths.pshtllthhhpt...t...ht...hsspshp...pht......plhptalppplst.thpspp	............................shhthhhuhalsELls+hl....t....c....p.....pst...st.........LFphhhpsLp.tL..............spsp............ss...thhthh.FElplLst.hG.ausshscCstsupssstthh.hh....................................................................................................................t.ppttpsttththsspshhlhphhtth..thpt.......ht........t..h.s.t.p.p..hp.........php.................phhphhh...c.a.lst...L+Sh.....................................................................................	0	279	551	713
+4105	PF02132	RecR		RecR protein	Mian N, Bateman A	anon	IPR000093	Family	\N	29.10	29.10	29.50	29.40	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.20	0.72	-4.52	192	4246	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	4214	6	904	2429	1218	41.00	38	20.52	CHANGED	p.tsppLApAltpstpplphCphCtslo-..p-....hCsICssspR.D	...............ts.cLApALhpApcclpaCshCtslT-..p-........sCpICs-spRD....	0	309	605	770
+4106	PF03837	RecT		RecT family	Aravind L	anon	Aravind L	Family	The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to RecT [1].	20.80	20.80	21.00	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.19	0.71	-5.02	81	1551	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1057	0	145	1046	127	180.60	24	65.71	CHANGED	sphhptshshlpp..........................pL...tt......ssspshhsslhpssphsLsPht....ppsYllsa.....................hs.tcsphhhuhcGhhplApRssphp..ulputslhctc.hphpht...........ht........ppsphlusaAhhhh.....psstp.h..hhhshpphppttp................p.ttt.........................s.W..tsp.cpMhcKsslpphhp+hhPhshp.............shhstDEh...............t.pppppsss	..........................................s....p.hhthlpp..........................th.....hp.......ssstphhshlh...ssphG..LsPhs....ppsYhl..P.................................ht.sth.phh.luhcG..h.plh....p..cstp..hc..........uhp.hp.s.hc....ht.t.........................................................t..hushshlhh.....pstsc..h...p.hhhc..phcp.hp.......................ptptt......................................usW..ps..p.......c....pMh.++pshhphh.+hhhshu.....................shhstDEt......pp.........t.ts................................................	0	44	96	119
+4107	PF03838	RecU		Recombination protein U	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Domain	\N	25.00	25.00	26.10	25.80	23.70	23.10	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.98	0.71	-4.73	43	1337	2012-10-11 20:44:43	2003-04-07 12:59:11	9	3	1214	10	140	682	9	163.20	48	83.68	CHANGED	NRGMoLEctINpoNpYYLspslAVIHKKPTPlQIV+VDYPpRStAsIpEAYF+psSTTDYNGVY+G+YlDFEAKET+NKouFPLcNhHpHQlpHhcplhpQsGIsFlllcFsshcchallsuppLhpaWpt..pssG+KSIPhs.I.....pcpuaplphshpPplsYLcsl-pl	.......................................pRGMohEc.INpoNpYYLppslAVIHKK.PTPlQIVcVDYPp.....RSpAhIsEA.YF.+psSTTDYsG...VY..p.G.h.Y.IDFEAKET+s.Ks.uFPh.....p.....NhHtHQIcHMcpshp.QpG..I..sFll.l+Fso..hpE.sYlLPsp...clhpaa.....psp.........G+KShsls.I.....cc.pGapI.phsh.t...Ppl.sYLcsl-p..............................................	0	47	90	115
+4108	PF02631	RecX		RecX family	Mian N, Bateman A	anon	COG2137	Family	RecX is a putative bacterial regulatory protein [1]. The gene  encoding RecX is found downstream of recA, and is thought to interact with the RecA protein.   	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.60	0.71	-3.91	147	4223	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	3600	6	808	2825	1656	117.80	22	66.09	CHANGED	Lpp+....h.sp.ch....lcpllscLpchsal.sDpcaActalcs+ht.pshGstplppcLp.pKGlsppllp.psLp....p..hs.tpp.......................Atplhp++hpph.....t....................hctcpKhhpaLhp+GFshchlpp...slp........ttt-	............................................h..st.p......hppllshhtc.thl.sDtcautthlpsp...t..ps.h...G...ttl.p.pcLt.p.K.G..ls......p....p..h..lc....ps.lp...........c..hc.pc..................................Apcl.hpKch.pph......ht.ss...............................................................hphcpKlhphLhp+Gash-.Ippslp........t.tp...................................	0	262	516	680
+4109	PF02014	Reeler		Reeler domain	Bateman A	anon	Bateman A	Family	\N	21.00	21.00	21.00	21.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.95	0.71	-3.90	40	496	2009-01-15 18:05:59	2003-04-07 12:59:11	11	45	110	8	357	521	42	122.60	24	18.03	CHANGED	sCschh...PpH......stsPp....sssaplsss..spsatsGpphpVsl....tt.ssspF.cGFhLpARssss.tt..........................lGpFsls.sss.hpphhsC.....sAVTH...ssspsKpplpl.hWsAPss.s.GslhFpATllpphtlaasc	.................................C.th.......tt..........ttp.t...sssap...ltss.........sptahsGpphpVol...................sst.F..cGFhlpAcptsspt...........................lGpFphh.ssp..........h..p.......h..hhsC.........................su..loH...sssp......tK..s..p.l.p..l.hWtAPs................ss....s...G...sV.hFpAT.ll.ppht.haah...........................	0	151	183	286
+4110	PF04221	RelB	DUF415; 	RelB antitoxin	Mifsud W	anon	COG3077	Family	RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes ([1], [2]). RelB stably binds RelE, presumably deactivating it.	20.90	20.90	21.00	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.44	0.72	-4.23	6	2614	2012-10-02 18:44:02	2003-04-07 12:59:11	7	4	1541	3	352	1624	75	79.40	22	87.15	CHANGED	suhlshRID-clKspAssVLcpMGLThSpAl+lhLsplApsculPF-lplPpsNptTlsuIpctctGps.......ppshsscchhscl	.............lphRlDpclKppApplhpphGlshosAlplhlpplspp..pu..lP..F....c.l....p.......h......s..................s.......p..ts.h....t.s.h.......p.....c.............................................................................	0	120	212	267
+4111	PF03763	Remorin_C		Remorin, C-terminal region 	Farmer EE, Finn RD	anon	Pfam-B_1798 (release 7.0)	Family	Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible.	22.10	22.10	23.80	23.60	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.77	0.71	-4.54	28	381	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	26	0	224	354	0	105.30	33	31.49	CHANGED	pccp..puhhsAW-EuEcuKhps+hp+cpscIsuWENpcKAKsEApl+KlEpc.LE+KKActtEKhpN+lAtl++cAEE+RAts......EA+Rscchh+scEtAs+h..RsTG+hPsphh	......................t..pthtshhsAW-c.u.EpuKhps+...hc.......+........c.cspIpuWEsppK....AKsEAph+.KhE..........t...c.lE+c+AcshEKhts+lAt.s++pAEEp....RAts......EAc+spchh+st-.tAshh....R.tsGphPtp..................	0	36	136	183
+4112	PF03766	Remorin_N		Remorin, N-terminal region 	Farmer EE, Finn RD	anon	Pfam-B_1798 (release 7.0)	Family	Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible. 	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.84	0.72	-4.19	5	55	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	19	0	34	55	0	59.00	43	30.80	CHANGED	ssVscEpApscsssPPPs..cpKsDDSKALsVVEsssEEsAscKsucGSlDRDVlLA+L	.......................ssc-hA.pEK...ss.sP...PPs.......cpc....s....DDSKALs.lVE...K.....ss.E.s.....stc....K..ss....p....GSl-RDssLA+l.	1	5	22	28
+4113	PF01244	Peptidase_M19	Renal_dipeptase; 	Membrane dipeptidase (Peptidase family M19)	Finn RD, Bateman A	anon	Prosite	Family	\N	20.20	20.20	20.40	20.20	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.68	0.70	-5.50	48	2249	2012-10-03 00:45:34	2003-04-07 12:59:11	16	15	1559	27	897	2181	2191	312.60	26	85.48	CHANGED	th.tph.llDuHsDhshphhtt.t.................t.t.hchsl.+h+pGtlsuthhula.h...........................thppuhptsLcplshhpphhpppsp.lplspossDlcpshp.cs+luhlhuhEGucsl..sscl...shLctaapLGlRhlsLTa.stsN.hucushpt........pssGLoshGcclVpchNcLGlllDlSHhucpshhDsl.......plSctPllhSHSsu+ulss+sR..NlsD-plcsltcsGGllslshhsta.lpps........................................................spuolc-hlcHl-alsslsG.h-aVGlGoDF.....DGss........................................stulcc...................suph.pLhptLhc.cGas-p-lcplhttNhlRVhcc	.........................................................................................h.......lhDsHsDh.h.t.h..................................tt....hphsh.+hp...pGtl.s.u......thhula..h..............................................tht..p.s.h.p.t..s..l.p...t....l.s....h....hpp.hh.....p..p.......s...........s.........lt.............h..s...p...os................s...D.......l......p.......p.....s.........h.........p.....p..........s.....+..........l.u............s.....llulE......uu......csl..........sssl...............shLc.h.h..a.p.h.........G.l..RhhsL.s........a.stsN.h.u...sushtp....................................ttsGL.o.s.h..G+p..llpch....N.clG..h.......hlDlSHhucpshh...-sl.............ph.o...p....t......P....ll.hSHSs.....s...p.ul.............s.........s.........p.s.........R................NlsDc.l....ctl........t....c.....p......GGllt.....lsh.....hstF..lpst...............................................................................................tpssl.pc..h....s.....cHlcalhpl.hG.....h-.p....lGlGoD..F............DG.ht.t...........................................................................................................................................................................................stslps............................s.u.p.h.s....plhtt.Lhc....p....G.........asc.........pclp....cl....h....ttNhlRlhp.t....................................................................................................................................................................................................................	1	281	511	734
+4114	PF01664	Reo_sigma1		Reovirus viral attachment protein sigma 1	Bashton M, Bateman A	anon	Pfam-B_1003 (release 4.1)	Family	This family consists of the reovirus sigma 1 hemagglutinin, cell attachment protein. This glycoprotein is a minor capsid  protein and also determines the serotype-specific humoral immune response. Sigma 1 consist of a fibrous tail and a globular head. The head has important roles in the cell attachment function of sigma 1  and determinant of the type-specific humoral immune response [2]. Reovirus is part of the orthoreovirus group of retroviruses with, a dsRNA genome. Also present in this family is bacteriophage SF6  Lysozyme Swiss:P21270.	25.00	25.00	43.90	38.50	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.31	0.70	-5.26	3	60	2012-10-01 20:11:45	2003-04-07 12:59:11	11	3	13	30	0	78	0	208.30	62	46.59	CHANGED	IsuLPSRlGoLEuS+IDSVlPPLslpSouuTRlLchhYDoSDFsIsNSVLoLRsRSToPTaRYPLELsSAsNpVulucNYRhRpGpWoGQLpYpsPuLsWRAsVTlNLM+VDDWLlLSFopFoTsSIhAuGKFVLNFVTGLSPGWtTGDTEPSoT..lsPLSTTFAAIQFlNGGuRlDAFRILGVuEWsDGELEI+NaGGTYTuHTNVcWAPMTIMYPCss	.FDuINSRluslEQSYVASsVsPLRLNSS..TKVLDMLIDSSTLEIN.SSGQLsVRSooPNLRYPIsDlSGu..IGMSPNYRFRQSMWIGlVSYSGSGLsWRVQVNSDIFIVDDYIHICLPAFDGFoIADGGDLSLNFVTGLLPPLLTGDTEPAFHsDlVTYGA.pTlAIGLSu.GGsPQYhSKNLWV.EQWQDGVLRLRVEGGG.ITHSNSKWPAMTlSYPRSF..	0	0	0	0
+4115	PF04582	Reo_sigmaC		Reovirus sigma C capsid protein	Mifsud W	anon	Pfam-B_2922 (release 7.5)	Family	\N	41.00	41.00	41.00	43.10	40.90	40.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.02	0.70	-5.26	4	160	2012-10-01 20:11:45	2003-04-07 12:59:11	7	1	59	7	0	145	0	239.10	45	97.25	CHANGED	MAGLsPpQRREVVuLILSLTSSsThNsGDLTslYERLosLEuustSLcpSluslsoclSDlSusLQshspoLs-spusLsuLposVpALpsSVssLSoslssLoshsSuHsuulSsLQTolcuNossISNLKSsVSupGLsIoDLppRVpuLESuoSpuLpFusPLSlusGVVSL-MDPYFCSpphuLTSYSA-AQLMQFQWhA+GpsGSSsoIDMsVNAHCHGRRTDYMMSoTtuLTVTuNsVoLsFsLDhIT+hPSDLSRLlPssGFQAASFPVDVSFTRDosTHuYQVYGsYSSuRVFpITFsTGGsGTANIRFLTVRTGIDT	........................Ls..QRREVluLILSLTSssshs..GDLs.lh-RLosLEuust.Lppo.......lssh.sploslSupLpshstslspspspLpsLptplpthpssl.s..ssslsshot..pspss.losLpsphss.tstlsNL+s..sV....s....s.uL..slosLppRlpslEsssup.hphtsPLp..lssGslSLphcPhFCo.phsLoSYSspA.LhpFpW.s+.upsGuu.sslsh.lpsHsHGpRTsahhSoptshTVs.usss.Lshsls.lhp.ssD.huhLlPstGFQtAoFPVDlSFpRsssoHsY..Qs..Y..GsaspsthFplsa.ssts.st................................................................	0	0	0	0
+4116	PF00979	Reovirus_cap		Reovirus outer capsid protein, Sigma 3	Finn RD, Bateman A	anon	Pfam-B_1049 (release 3.0)	Family	Sigma 3 is the major outer capsid protein of reovirus [1]. Sigma 3 is encoded by genome segment 4.  Sigma 3 binds to  double stranded RNA and associates with polypeptide u1 and  its cleavage product u1C to form the outer shell of the virion. The Sigma 3 protein possesses a zinc-finger motif and an RNA-binding domain in the N and C termini respectively. This protein is also thought to play a role in pathogenesis.  	18.40	18.40	18.50	22.40	17.90	18.30	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.30	0.70	-5.51	5	149	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	31	5	0	145	0	250.80	49	98.83	CHANGED	MEVRVPNFHSFVEGITSSYl+sPACWNA+TuWDospFapPDVI+VGNAYCCoQCCGVLYYGuhPsDGpaFPHHKCHQQppRsDoPLLRaVRIGRTTEHLLD...QYAVtLpoIADHY--tupcpscEPtuDpVAuLDIlsRTESlRoDpAVDsDFWTsPLERRsD.DSRRDIA.oAhW+MIDASupShTLPDCLVSsuLHoRslFcQM..tTTToIYDVAsSGKsu+FSPMVAshPpR-uGPlpLsccssc-sVsosWp..sHF.......AlSPIIGGVG.IoGQatRsShHpVGHPlIGSGKKlSHYRNLFM-lsRGWSKSoFsCAsGLEPAE.sESRLRGHARTMLGRo....LPcVCDaussspossssoPLp..+osKlThlECG	.........phl-.h.sua.th...asstphWt.....h.P-hhhhGsAhsC.pChGVl..G....t...hPHH+CpQ...p.s.s.hphsc..RhTthhhc...tash.hpthhp.hp..t........tt.l.......................ps.hp.....s.............p...Wp.sl...p.....sst...h..tth.hh.ps........hlsphhh....as.thht.......hoIYDVAsSGK.ul+FS..PMVushu...pR-uGPlhLssssst-sVhohhp..uHF.......AhSPllGGVu.loGpatRtShH..hhshltsstKhp..Rph..t...sat..ththhhs............................................................h................	0	0	0	0
+4117	PF01446	Rep_1	Rep; 	Replication protein	Bateman A	anon	Prodom_1565 (release 99.1)	Family	Replication proteins (rep) are involved in plasmid replication. The Rep protein binds to the plasmid DNA and nicks it at the double strand origin  (dso) of replication.  The 3'-hydroxyl end created is extended by the host DNA replicase, and the 5' end is displaced during synthesis. At the end of one replication round, Rep introduces a second single stranded break at the dso and ligates the ssDNA extremities generating one double-stranded plasmid and one circular ssDNA form. Complementary strand synthesis of the circular ssDNA is usually initiated at the single-stranded origin by the host RNA polymerase [1].	26.00	26.00	26.20	26.10	25.70	25.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.67	0.70	-5.02	25	775	2012-10-02 18:54:06	2003-04-07 12:59:11	12	3	413	0	22	552	35	156.80	31	69.80	CHANGED	hKhuhpsppIlscuhpcpPpuRaLFLTLTV+Nsp..G-cLcpolspMscuFpRLhpaKK.........hppsllGalRusEVThNc.pcs.....oYHPHhHVLLhVcsoYFp......pNYlsQs-WscLWc+uh........KlDYcPlVcl+sVKspp.........pp..psl..p..................sAlhEsuKYsVKssDhhsssp......ts.pslh-LppuLtppR.IuaGGLLKpI+....+cLpL-DsE..puDLlpss--ccp.spsp......plhhhWphpppsYhl	.........................................th.....t...t...h..lFLTL.oh..Ns......hpp...Lpttlpthtpu...ap+h...phpp....................h.ts.....hhG...ah...+thE.l.Thsp......ps................................ap.HhHhllhlp...shht.......t.altp...tpW.phWp.p.sh......................ths.....s.......hplp.hp..........................................................................h.p......h...............................................lsauGlhKph+.......K.Lp....s-h........shlp..p.pp............phh.......................................................................................................................	0	8	12	22
+4118	PF04057	Rep-A_N	Rep-A_protein_1;	Replication factor-A protein 1, N-terminal domain	Wood V, Finn RD	anon	Pfam-B_6000 (release 7.3);	Domain	\N	21.70	21.70	22.00	21.90	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.19	0.72	-4.22	11	381	2012-10-03 20:18:03	2003-04-07 12:59:11	7	20	239	3	250	351	3	97.50	29	16.47	CHANGED	LTsGAIutlhs....u-ssh....cPVLQVl-lK.Iss.......sspRYRhlhSDGpst.hpu.MLuoQLNshVcsGplppsullpLpcalsNslpt...sR+llllhpLEVlsp	.......................................................lo.GAlttlhp.......spss......pPllQllsl+..lss.............sssspRaRllhSDGhph.hpu.MLATQL.NphlcsspLpp.s.sllplpc...ahssslp........s++.l.lI.lhclEVlt.............................	0	86	146	208
+4119	PF01719	Rep_2		Plasmid replication protein	Bashton M, Bateman A	anon	Pfam-B_1901 (release 4.1)	Family	This family consists of various bacterial plasmid replication (Rep)  proteins. These proteins are essential for replication of plasmids, the Rep proteins are topoisomerases that nick the positive stand at the plus origin of replication and also at the single-strand conversion sequence [2].	25.00	25.00	25.10	25.10	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.46	0.71	-4.80	24	278	2009-09-17 10:57:14	2003-04-07 12:59:11	12	4	204	9	32	240	1	182.60	27	74.28	CHANGED	hsKcpt.............RpWsFllYP..ESh.....PcsWpphL..-phtl.hhhSPLHDKDls.............psGchKKsHaHlllhacsspohppVpplhcph........susthspl..tslcshYcYhsHts....s.cKapYshs-IhshsGF.....DIcpalshssp.c+.p..llppllchIc-pslh...php-Lhpashppt.c..hhslhtppsh..........hFhspY.lcupptp	.................................................................................pt..........phasFlhY....ESh.....Ppsahp...hL......-pht.lsh.hhSPhHDKDls..............psschKKs...HhHshhhacshpohsplppllpph..............sssthlphh....hS.....pshapYhsHtp....ss-Kp....YshpDItshsGF...........-l-calh.ssp.p..p.p.....hlppll-hIccpshh...php-Lhtahhtpt.p...hhshhh.ps...........hh.ttY.cpth..t........................................................................................	0	2	6	23
+4120	PF01051	Rep_3	RepB_protein; 	Initiator Replication protein	Finn RD, Bateman A	anon	Pfam-B_313 (release 3.0)	Family	This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene [3,4].	22.40	22.40	22.90	22.40	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-4.75	166	2007	2012-10-04 14:01:12	2003-04-07 12:59:11	16	8	1146	6	232	1665	74	220.10	17	69.43	CHANGED	ppthlhpsNsll.psshp........hohtEh+lhhhhluplcsp..ttpt.....................h.h...phtcht.th....shspps....hpplppshppLh.cch.hph.......................tppht.hhhhhtahp...................tpuplpl..phspclhshLhpL...pp..p..F.TpapLpphtp.l.cSpYohpLYclL.....ppa....................cs....hsp..hp..........hsl.......-...........-h+p........hhsl.........................sph.phschcp+VL.csulcE...lsp........pssh.tlphcph.+...pG.......Rp...lsslpFph	.....................................................................................t...hh..pNph.h.ps..t.......hshhphplhh...hhltphppp......pptt..................................hph.....shpchh.th...............thpsps........hpplcpshppL...pp..hph...............................pt.......hh.ahs.h...............................tpshlpl.....phs.sp........lt..hlhph........pp...t...a.sphplpphsp.L.cup..auhpLa.clh..........hpa.........................ps....ttt........hh...........lpl...........p...............................-h+p........hlp.l...........................................tsth...phs..phcp+ll..csslp-.....lsp........................hsph..tlshpph..+.........cG....Rp....l.th.F........................................................................................................	0	58	131	189
+4121	PF02486	Rep_trans		Replication initiation factor	Mian N, Bateman A	anon	Pfam-B_2164 (release 5.4) & COG2946	Family	Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a  sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family,  including myelin transcription factor 2 (Swiss:O15150) and cerebrin-50 (Swiss:Q16301) [2].	29.60	29.60	29.60	29.70	29.40	29.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.19	0.71	-4.80	84	1463	2009-09-11 00:34:10	2003-04-07 12:59:11	14	8	833	0	83	967	19	187.80	25	54.34	CHANGED	hhssploRlDlAhD.hpt..........hshschhpph.ppsthhpph.........p...............hpphushp.............hGpThYlGu+.pSp...hhhRlY-KshE...............t..p..WhRhElcL+spct..hshchlhs.....tp.hsshhhthhphh.....................................t.tthpl.....ssphp..ths.......................h-pt....hpalpc....psutslphltph.t......................tphpshltpllpp	...........................................................h..sthsRlDLAlD-hss.........hhshspltcch.pptchhsth................hp...................hpphtssp.......................pt.thGpT.hYlGSp..pSp......hahplY-KshEph.......................t..hcp..sph..hsRhElcL+pccs....h....hshc.Lhs..............hp...hpthhhthhsthhphh................................hhtthp.lcl.........ssp.c....ho...........................hccs.....hpWlp.+....Qs.u.slthh..ph.t............tpphh..h...p...........................................................................................................	0	24	46	64
+4122	PF04796	RepA_C		Plasmid encoded RepA protein	Waterfield DI. Finn RD	anon	Pfam-B_6223 (release 7.5)	Family	Family of plasmid encoded proteins involved in plasmid replication.  The role of RepA in the replication process is not clearly understood [1].	21.40	21.40	21.50	21.60	18.90	21.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.90	0.71	-4.63	10	189	2012-10-04 14:01:12	2003-04-07 12:59:11	7	2	146	0	63	178	18	157.60	32	48.85	CHANGED	lPYGshPRLlhsaLsT......cAl+o+o.............slpLGpShocFlccLGhps..oGGtpGslsslR-QlsRLuussh..........sluhcsuscu..sspshslhccthhhW.spcss.....QpuLas..SpVpLopsFFcpLtc+PVPlDhsAl+tLppSPhuLDlYsWLoYRlphl..s.+s....ssloWcp	.................................................................lPYGshsRLlLhalsT......pAl...+s+sR............clpL.G...pShspFh.c.t.hGlss..pGGc..shptlRcQhpRLhuspl...............................................phthp..s....sts.........thh.shthscph......h..h....h.hps.p..pss...............Qt.uh...at....sh.....lpLS-sFappL.hc+sVPlDhcAl+tLp...t..SshAlDlYsWLsYRlatl....p..+s....shlsWp.s..............	0	21	45	54
+4123	PF01421	Reprolysin		Reprolysin (M12B) family zinc metalloprotease 	Bateman A	anon	Swissprot	Domain	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.  Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin Swiss:Q28472.  Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.29	0.71	-4.73	38	3201	2012-10-03 04:41:15	2003-04-07 12:59:11	14	123	179	77	1444	3423	29	190.20	28	23.35	CHANGED	+YlELhlVsD+thap+hsushstl+p+lapllNhlNphYps.LNlpVsLsuLEIWospDpIslpssussTLppFspWRcp.Llp++pHDsApLLouhsass.slGhAahuuhCsscpSsGlspcap..pshhlAlhMAHELGHNLGhpHDst.....tCpC....ssssCIMss.huppsuh.hFSsCShppappFlpptpspClhNpP	..................................................................................................................................................+alEhhlVsD.pt...h...h......p....h........h.....s.....t.....s.....h......p.....t..hp.p..hlhpl.....h..N..h..........l......s...t..h...........a........pp........l......s.........l....p.......l....s...L.......l...s...l......t.....l..............a.........s.............p...........p............s...........t........l.......p......l...........s..................t.........s...........s.................s.......p..........o...L..p...sF.....s......p.....W.....p...p.............p.............h....h......t........p...........p...............p...........H...............D.....s.........A........h..L.l..T.........t.........p.............s..........h..........s.........s.........t..........s.............l........G............h.....A................l.........u.........uh.............C......s....s...t.........p..........S............s.......u.............l.s........p................-..............p...........................s.........h.........sh.A..............h......oh..........AHE..l.G...............H............s........lGMp.HDss.............pC......p.........C.................sttss......lM......us....h.......s......t.......t...............s.h.....taSsC..Stpp.h.pp..a......L....p...p.....t..t....s...p.CLhs.P................................................................	0	219	301	684
+4124	PF05140	ResB		ResB-like family 	Finn RD	anon	Pfam-B_1866 (release 7.7)	Family	This family includes both ResB and cytochrome c biogenesis  proteins [1,2].  Mutations in ResB indicate that they are  essential for growth [1].  ResB is predicted to be a  transmembrane protein [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.68	0.70	-5.94	127	1951	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	1367	0	559	1727	720	307.30	18	58.66	CHANGED	h+hAlhLLlllAluSlhGTllP.Qp................ss.Yhppa........G..hhuplh.pLsL.clYsShWFhsllhlLslSLlsCslpRthshh+sh+ph..htptp..Lp+hshttphph...........................s.psshppltthLcpp.tac..lptpptp.................lhAcKGhhs+hGsllsHhullllllGuhhuuhh....................................uac........uphhls..pG...........psssh......sG..........saslclccFpl-ahs.................sG.tscpFtSclslhcss...........pp..hpptplpVN.cPLpacGhslYQssau.sshphhthsssh....tt....h.phshphhs.sst...............................plplhuhhhs...........................................................pp.psssPsltlplhs.ptth......................................................................................................................sspspthhthphsphpthphssh.........................................................................hlph...........stshp......hoGLplp+DPGhslValGshlhllGlhhuhalpcRRlWlhhps...........................tsplhluGhss+sphu.atcEhtc	............................................................................................................................................................................................................................................................................................................................................htc.h..s.hh.Hhuhlhhhhuhhht..........................................................................................................................h..p..t..h..l...ts.......................pt....h................................hsaplplpcF..hphhs.....................................................................................................pt...sppatopltlhptt.........................tp...hphplthN.cPLph.t.Ghp.h..Y....ua.s..s..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t............................................................................................................................................................................................................	0	197	410	519
+4125	PF04851	ResIII		Type III restriction enzyme, res subunit	Finn RD, Mifsud W	anon	Pfam-B_4631 (release 7.6)	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.52	0.71	-4.46	55	18536	2012-10-05 12:31:08	2003-04-07 12:59:11	10	220	5248	26	4564	43274	12710	160.50	19	20.83	CHANGED	phphRsaQtpAlcplhpthppt...............................ppcsllhhsTGoGKThhuh.........t...hhtclhp..................+sLFls...sppsLhcQsh.cpa........................................pttt.th..t...pstphhhsslQpLpt.................................ph..stas..................lllhDEsH+ususs...................applhp.................hpsthh......lGhTATP..pc	............................................................................................................................................................................................h....p..Q.pAl..p...p....lh.p.t...hppt......................................................................................................tp.pt.l..l....h..t..sT...G...oGK....T..h..s..h.h...................................................................................p......hh..t.p.ltc.................................................psl..l....l...s.......s...p....p....s....L....s......s...Q...hh...pch.............................................................................................................................................................t.........h...............t.....t....t......t.......h..................................................................t...........t..........t...............t.....h.......h.......h..............h..t......h.................................................................................................................................................................................................................................hh.l...h.DEs.......H....t.........................................................................................h.t............................................................h....h.o..uT..................................................................................................................................................................................................................	1	1830	3138	3952
+4126	PF00239	Resolvase	recombinase; resolvase; 	Resolvase, N terminal domain	Finn RD, Griffiths-Jones SR, Bateman A	anon	Prosite & Pfam-B_3830 (Release 7.5)	Domain	The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface.  The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see Pfam:PF02796.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.83	0.71	-4.32	222	13550	2009-01-15 18:05:59	2003-04-07 12:59:11	16	84	3644	51	2369	10593	1582	133.80	24	45.62	CHANGED	hhuYsRV..STpc....Qs.....hppQ.hptLcphu.sp.........p.l.....at-c.hSGpp....t.p..R..stlpchlp.tlcp..s...D..s......llVtclDRLuRs.ht-hlpl.lcpl.pppGlplhsls..p......hcs............sssh.uch...hhslhush....Ach..E+phlp-RsppG.lttA+t...pGch	......................................................................hhYsRl...Sotc............Qs..........hpt..Q..h.....p..t..l.p.p....hs.pp................t..l.............apD.p.....hSGtp.................h.p.......R........sthpc.h.lp...tlcp.........s.....D....h..............................llVtclD...RL.uRs..ht-h.hph..l.p..tl....p...p......p..s..lp...l.hsls..p..s............hcs......................................sssh...sch..........hhp.l..h.u.s.h..................Ach......Epc.........h..htcR.hpt...Ghtt.ttt.pG...............................................................................	1	844	1618	2027
+4127	PF00072	Response_reg	response_reg; 	Response regulator receiver domain	Sonnhammer ELL, Griffiths-Jones SR, Finn R, Fenech M	anon	Prodom	Domain	This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.07	0.71	-4.06	57	151337	2012-10-01 22:20:39	2003-04-07 12:59:11	19	3468	5531	462	44329	116945	19054	111.60	26	30.95	CHANGED	lLlV.DDcshhpphlpphlp.....p.tuh...pVs.tsssuppulphl....pppp.....hDlllhD..........lphPs..h...sGlclhppl.+pps...s...ssllhlT.upss..thshpul.psG.ApsalsKPh.shscLhptlp	........................................................................................lLlV...-.D..c.........h....h....t....p....h....l....p....p....h.Lp.............p...tu....a........................p........l.......t.....t.....u.........s......s..G.....p....p..A.l..p...h.h...................pp..pp...........................................D.....l......l..l..h..D................................................l.t.....h.....P.....s.....h................s..G.....h.......c.....l......h...c.....p....l....+ppt.....................p.........................h..P..l..l............h....l........T.....u........p........s........p...........t............s.........t..........h.....p.......u...........l.....c...........h......G......A.....s........-....Y.....l...s...K.P...h...s...pc.Lhttl.t....................................................................	2	15208	29453	37848
+4128	PF02813	Retro_M		Retroviral M domain	Bateman A	anon	Bateman A	Family	Retroviruses contain a small protein, MA (matrix), which forms a protein lining immediately beneath the phospholipid membrane of the mature virus particle. MA is located in the N-terminal region of the Gag precursor polyprotein. The N-terminal segment of MA proteins directs the Gag protein to the plasma membrane where budding takes place, and has been called the M domain.  This domain forms an alpha helical bundle structure.	25.00	25.00	25.40	42.10	24.10	19.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.96	0.72	-3.82	3	206	2012-10-01 20:35:47	2003-04-07 12:59:11	9	15	46	1	0	218	0	81.30	90	16.63	CHANGED	DsVIKVLsohCKDYCGKTSPS+KEIuosLSLLpcEGtLcSPSDIausupWDhlTAALoQRAMsuuKAGELKTWGLlLGALKAAREE	...............ACKTYCG.....KTSPSKKEIGAMLSLLQKEGLLhSPSDLY.....SPGSWDPITAALSQRAMVLGKSGELKTWGLVLGALKAAREE.	0	0	0	0
+4129	PF00424	REV		REV protein (anti-repression trans-activator protein)	Finn RD	anon	Pfam-B_169 (release 1.0)	Family	\N	20.80	20.60	20.80	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.33	0.72	-4.09	13	15943	2009-09-12 07:43:04	2003-04-07 12:59:11	13	3	89	13	1	6741	0	83.00	60	88.13	CHANGED	Mst+st...-EtL+RtLRLI+lLaQoN.PYPp.ssGTApQRRpRRRRWRpR.cQIhALA-RIhsh..-.PhspPlDptl.cLQcLsIQpLPDP.....................Psss	......................................................................................................P..Po....sEG.T.RQA.RRNRRRRWRpRQR.QIcu.ISthILSohL......GR.P.sEPVPLQLPPLERLoLDCsEDC.GT.oGTpsssssphh............	0	1	1	1
+4130	PF00472	RF-1		RF-1 domain	Bateman A, Finn RD	anon	Prosite	Family	This domain is found in peptide chain release factors such as RF-1 (Swiss:P07011) and RF-2 (Swiss:P07012), and a number of smaller proteins of unknown function such as Swiss:P40711. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.	21.30	21.30	21.50	21.40	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.28	100	11930	2012-10-03 10:08:23	2003-04-07 12:59:11	15	22	4796	19	3127	8043	5160	115.70	40	37.79	CHANGED	.hstsh.clplsts-lclcsh.RuoGsGGQpVNKssSA....................V+l.pHh.......Pou..................lllpsQppRSQhpNRcpAhchLpu+Lhph...t........hpcpcppppsp+tuphcph-tupc..hRsYsh..psplKDtR	........................................cphclcIs.s.sDl+lD.sa.R.u.SGAGG.........Q+V.N+..T-SA...........................................VRl..THl.........PTG..............................................IVVps...Q...s-RS..Qpp......N+cpAhphLp..A+L.hph.p......................hpcp...p.t....pt..s.s.tR.p...s...p...h..t...t..h...s....tu..pp..IRo..Ysh...PpsplpDhR..............................................................	0	1030	1966	2619
+4131	PF04506	Rft-1		Rft protein	Wood V, Bateman A	anon	Wood V	Family	\N	20.80	20.80	23.20	22.70	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.70	0.70	-6.14	4	365	2012-10-02 21:24:20	2003-04-07 12:59:11	8	9	278	0	263	371	4	394.10	23	88.38	CHANGED	pSShpGhsaslhhQlhsRIlTFhlNthllRhlusclhGlssl+LplLpSTlLFLSREulRhAtlphsups...h.pss.tch.pphaLSs.lpsllss..sYI.h.aluhs.ulhhSha.ahslss....lh.shucsslFlhhl.phlcL..L.psaahlsQhhlhhstpstscuhuhhhsulhphtlsshs...p.............cuhuhL.Fshsslu.plp.huhhca.thps......FSshLsKltp.......p.......haasp-hlphhhohhhQslLKpLLT-G-Khlhsh..lhShp-QusYsllsNhGSllsRhlFpPIE-ssphaFuphlppcsphsp......+pulslLsplL+hhuhluhlhhsFG.sYSshVL.hhuGscaussus.tslLphYshYI.hhAlNGIhEuFhhusssucQIhcauhhhhshSlhaLlhualLhsh..hustGhIlANIINMslRIlYshhaIp+.a+-hshs.ohshshh.sphhlhshhhusllsaWh.ups.hLsahlsslhhuhshLhhhhlsc+phhphhhhhhsphthK	................................................t..........hhhQlh.+hhoFhhNthllR..hls.t...hhGl..s...pl..lh..ohlFhuREuhRhuh.p.......t...................................t.............t............................................................thh..hs.h.......hh...h..................................h...................................h.h....shh..lh.h...s..hhlcL..hsEs..h..a....h.l.p...h.hth.+..hhc.....s.h.....uh..hhh.sh.h.p.hh..hh......h.h...................................................hh....h.h...h..h.......h.hh....h..h.......h..................................................h........h......h..........................................................hp....t.h...ph.hhp.hhhQuhhKplLT-.G-p..hlh.s...h...h..............ohtpQG.hYslssNh........GSLlsRhlFtP..lEEo...hhhFup.............h.l...................t.........p...........t.........p........t...................p................................................................................t......sh.....p..........h.L....t.......ll+hhhhluh.hhhshG..shu.hhLpl.h.....h...G...t..t..hs...sst.......s.......................hLphY.......s.h...Yl...................hL........AhNGlhEs.Fh.ushs.t.pp...............ltp..shhhhhhShhahh...hs...h..h.hh......t..............hG...s....G.............hlhANhhNMhh.RIhas....hhal....tp.......h.h.......t.....t............................................................................................................................................................................................................................hh.hh............................................................................	0	96	153	222
+4132	PF04589	RFX1_trans_act		RFX1 transcription activation region      	Kerrison ND	anon	DOMO:DM04454;	Family	The RFX family is a family of winged-helix DNA binding proteins.  RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region  (Pfam:PF02257) in some mammalian RFX proteins, and is thought to activate  transcription when associated with DNA.  Deletion analysis has identified  the region 233-351 in human RFX1 (Swiss:P22670) as being required for  maximal activation [1].	25.00	25.00	28.80	28.80	18.60	23.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.25	0.71	-4.49	8	197	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	39	0	75	132	0	135.80	50	21.09	CHANGED	MQsSEuGSDosuoV.sLpTSsuuQu....sVPuoQpRslVQshsps.Kst.sQQl......sV.hsQQVsQQVQQ..VQHVYsuQVQYV.EGu-uVYTNGsIR.oAYoY.sEoQlYuQoSGuuYFDoQ...GuuAQ.....VTTVVSS.......HoMV.......GIsMsVuG.SQIISSo.uuYLItGG	.......................................psucsuusssuoV..tLpspsstQ......Vs.sp.................sQ.l......sV.......p...s.....Qp.VQQ...VQHVYPuQVQYV.EG.uD..sVYTNGAI.R.osYsY.sEoQhYoQs..o...uusYF-sQ......GouAQ.......VTTssSS.......HuMV.....soGGIsMsVsG.uQllSSo..GsYLIts.s............................................................	0	3	8	28
+4133	PF02257	RFX_DNA_binding		RFX DNA-binding domain	Bateman A, Mian N	anon	Pfam-B_3682 (release 5.2)	Domain	RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].	27.00	27.00	27.20	27.30	26.40	26.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-9.78	0.72	-3.84	34	732	2012-10-04 14:01:12	2003-04-07 12:59:11	10	11	217	2	423	656	0	83.20	43	10.10	CHANGED	c+p+phaA.hhWLhsshE.tsp.ssslPRs.......................plYscYhptCsppp.lcPLssAoFGKLlRslFPsl+TRRLGs..........................RGpSKY....HYs.....Gl+l+sss	...................p......hs..hpWLhsshE..pspssslPRs.......................plYscYhpaC..............p.............p..............pp.h.cP.lsuAoFG.......KlIRplFPsl+TRRLG.o..........................R..GpSK...Y..........H..Yh.....Gl+lK...s................................	0	100	152	268
+4134	PF03214	RGP		Reversibly glycosylated polypeptide	Mifsud W	anon	Pfam-B_2662 (release 6.5)	Family	\N	23.80	23.80	29.90	29.80	23.70	22.40	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.19	0.70	-5.70	4	169	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	63	0	94	181	3	299.80	50	91.75	CHANGED	MSh..IpcsEVDIVIuALpsNLTsFhppWRPFFStFHLIlVKDP-hp.cclplPEGFss-lYs+oDhE+VlGup.sSIpFSGauCRYFGaLVSKKKYlloIDDDClPAKDsuGhsVDAVsQHlhNLcoPATPFFFNTLYDPaRcGADFVRGYPFSLRpGVsCAhSCGLWLNlADhDAPTQslKsppRNTpYVDAVMTVPttAMhPlSGINlAFNRELlGPAhhPALhLtGEGKhRW-TlEDlWsGhCsKllCDHLuhGVKTGLPYVWRs..EtGsAl-SL+KEWEGlKlMEcllPFFpSlKLspTusssEDCVIELActVKEpLGp.DPhFsKAADAMhcWlcLW+Slss.SA	....................................................................................................................................................s........cs-lDIVIsslp.sL.sFhp.WRPahp.aHLIlVpDsD.t.c.lplPpGFDhclYs+sD....lp+..lLGsp..ss.IsFpspuCRsFG..ah...VS...+K...KYlh.oID.DDChsA..K..D.ss..GpplsAl..pQ..H..l..pNLhsPSTPa....FFN..TLYD.PaRc.....GA.D.FVRGYPFS.L.........R..........E..........G............l........s........T..........A.........lSpGLWLNlPDYDAPTpL.V......K.........Ph.....cR..NoR...........Y..VD...A..V....hTlP+GshhPhCGMNLAFcR-LIGPAMaF..GL..hscGp.....slGRaD...DhWuGaCsKVlC.DHLGhGVKTGLPYlaHS.........KA.u.s.s.FssL+K.EacGlhhpE.-llPFFQs.....st.L.s.....cpss..oVp.pCYhE.Luc.V+p+...L..ut..l.....Ds..hFt.K.hA-AMlsWlcuWcplss...st......................................................	0	14	66	82
+4135	PF05045	RgpF		Rhamnan synthesis protein F	Moxon SJ	anon	Pfam-B_5448 (release 7.7)	Family	This family consists of a group of proteins which are related to the Streptococcus rhamnose-glucose polysaccharide assembly protein (RgpF). Rhamnan backbones are found in several O polysaccharides of phytopathogenic bacteria and are regarded as pathogenic factors [1].	25.00	25.00	26.50	26.00	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.78	0.70	-5.97	7	464	2009-01-15 18:05:59	2003-04-07 12:59:11	7	50	316	0	120	454	62	322.40	20	50.84	CHANGED	llFlSNuplocpspppLps..hsDchl.RENpGFDhhAa+-Gl-hlGFDcLspYDplhlhNcThaGPla.huphFpchEp+.ssDFWGIosH+thp.s....tsthhscHlpSaFIuh+psllpSpsFcsaWcshsphpsht-sl.haEophTshFhshGaphpshlDoc+hsusa..hlcsD.ohhs.ssILK+Rl.Fhcsphl-spth...hPhhLchlccsosYslsLIhcpl.chu.P.sLs.....h.lLsschlps.ttss.sptKlAVphHlYYsDhL-EhLshhpNhshsYDLhlTTsos-K+tEIcph.L.ptsG.pss.VhVs.tN+GRDhsshh.sL+-hL..c+YDhVs+hHTKKS.pssh.tGp.a+cchl-.Llcs...scNlLshFcpNsplGlslssl.sahpasplspAW.tN...tsphtclh+phslph+hD....sT.VhuYGThaWF+.cAL+pLF-hchp.cDhssEP.hspsolhHAlERLlsYhAhssuY	................................................................................................................................................................................s.....h............t.l...........h.t...hh.RpN.GaDhhuappu.h....h.....t..h..ph.splhlhNco..hG.Ph.........ht...hh.tp..ht..t.p....thDhaGho.......t....................................h..HlQSaahsh....pt.hhts..F.paWpth...h.p.s..htpsl..aE..hophh.p..Ghphtsh..h..........................................................h.................hh......t...............................................................................................................................hhhhHhh...hh.th.t.......h.........hphhho...h.............h.t...h.................h......ph.psh..hh..........h....t..hthhhhhps...+p..........................................t.t.h.t....hht.hh...........htt...h..t.http..hu.hhhs.......................................................................h...h...th.........h............................G...shhah+......thht..h.t......t..............h....................t.....hE........................................................................................................................................	0	26	73	97
+4136	PF00615	RGS		Regulator of G protein signaling domain	Ponting C, Schultz J, Bork P	anon	SMART	Domain	RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.78	0.71	-4.00	74	4150	2012-10-03 22:10:09	2003-04-07 12:59:11	14	139	303	83	2509	3808	11	120.60	21	22.88	CHANGED	ohcpllssps.GhphFppFLcsphsc..-slpFWhusc-a+pt..........................sppchhpp..AppIapcalt.sus.ppl.sl-ppstpthppslpp............................ss.shFc.tuQpplhp.hhcp-sas+FLcS..shYpch	.........................................................................hppllps....uhthF.p....p...F..L.c.p.ch.st...........-sl.............p.....Fa...hss.c.ca+ph.............................................................................................................................s.p.p..p.htpp......uppI..a..ppa.l....t.........s..p....us...p.........p....l...s...l.s...p......p.....s..p..p..p...l..p..p..p.lpp.......................................................................................................ss.ph.Fc..pup..p..p.lhp.....hh..c..p..c..s..a..scFlpS.tha.p........................................................................................................	1	835	1141	1805
+4137	PF00974	Rhabdo_glycop	Rhabd_glycop;	Rhabdovirus spike glycoprotein	Finn RD, Bateman A	anon	Pfam-B_167 (release 3.0)	Family	Frequently abbreviated to G protein.  The glycoprotein spike is made up of a trimer of G proteins. Channel formed by glycoprotein spike is thought to function in a similar manner to Influenza virus M2 protein channel, thus allowing a signal to pass across the viral membrane to signal for viral uncoating.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	501	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.53	0.70	-6.27	8	3017	2009-09-17 10:48:14	2003-04-07 12:59:11	13	3	114	5	2	2015	0	333.50	41	96.20	CHANGED	hlslllllthsss.hsp..PlhssssspssWs.Pl.sashsCPssthspscuupspsPhpac-.ssGhlosspV.GalCpu....slapsssah+aVGY+shT....Fut+slcPTls-C+tAhpchssGsspsppsLaFPsPsCtWhosVsss-tshhhlTP+oVplDsYstcalDscF.uG+Copps.....CpTpassolWhs-ss.hpstCsp.hpplcGhhasspsSppsshus....cpGa+Pah.LcsuCplsFCGK.GIRhspG-Wlulsss....sssphhshPpClss.....lsshRssts-ashls-Ll+...cRpECL-sascIhsopsloshcLS+hRshtPGhGcsYslhNGoLhcupspYlpV-h...-lh.s+ssh+stspsshhhWsph..FGshhtG.cGlltss..phphP.lppasulh-suhh.hhpst.lPHPshpsspsspD.......hhsschts.tpsl-slDhthssWuhalhluuhsllsllLllllhpCCshssp..pPptppsIshpphsps..p	............................................................................................................Wp.sl.ht..tCsp.s......s.......cs..s.p....hsshpa.c..p.uhlss.ph.tahshu....shhtsts.hphhshhshs....athpphc.h..ts+.uhp.thstssphcts.h.P.PshtWhpsshppc.ohhhloPpssplDsYs+phhsp.F.sGcCps..s.......CpTpashslWhs-ps....tspCDh.......hp..s.....cG......hh.ss....c..ts..c..p.sshss................ptGha....LctACplphCGh.Gl+h.pGshlthps..........ssth..hhs....Pcphss..................hhsh+.ssp.-a.....hl..p.-.L.l+.......pRp...c...CL-shppIhsstslo.h.LShht....G.s...sahh..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	2
+4138	PF03342	Rhabdo_M1		Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)	Mifsud W	anon	Pfam-B_3629 (release 6.5)	Family	\N	25.00	25.00	319.20	319.00	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.29	0.70	-5.21	4	24	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	9	0	0	24	0	221.50	62	98.90	CHANGED	MuD..p.GEphhs..u.sLhcL-u+LcN.s.cDuplsth.u..KcssshptE...osK+pscPp....LEpllL+aVsEcpplDAhKcFGtLItpI+.SHQtELTpHLE+VusEpRANLpALhcSQpEppKsoKpILSslIulRuplsENuS.+PKsLDhDQV+sERALGFshGYpTAlslhs+lKshsPppssptpVKshAlpAhEc-EYEGStphF+pVlctlKtchc	MuD.IEMuEpLVLSHG.SLADLD+RLDN.APKDsRuALFSS..sssso+QKs...SPKKKssPT...TLEElIGHFVsEDLQLDAsKAFGQLLRRIKhSHQEELTQHLEKVNsEpRAKMGALLESQKENGKKTDNILSILIuMRGEGAENASKKPKVLDGDQVRNERALGFNRGLTTAAIAMKKFKLEDPLsLCKGSVKRAALSAMEKEEYDGpRETYusVuKAlKA-lc.	0	0	0	0
+4139	PF04785	Rhabdo_M2		Rhabdovirus matrix protein M2	Kerrison ND	anon	Pfam-B_2486 (release 7.6)	Family	M protein is involved in condensing and targeting the ribonucleoprotein (RNP) coil to the plasma membrane.  M interacts specifically with the transmembrane spike protein (G) is important for the incorporation of G  protein into budding virions [1].	25.00	25.00	414.40	414.30	16.80	16.70	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.28	0.71	-5.28	4	134	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	30	1	0	136	0	202.00	89	99.89	CHANGED	MNhLRKhlKoC+D-EoQKssssSAPPDDDDLWLPPPEYVPLpEloGKtNhRNFCIsGEVKlCSPNGYSF+IlRHIL+SF-sVYSGNRRMIGLVKVVIGLsLSGSPVPEGMNWVYKLRRTLIFQWA-SpGPLEGEELEYSQEITWDDDoEFVGLQIRVsA+QCHIQGRlWCINMNSRACQLWSDMoLpTQQS-EDcsTSLLLE	MNFLRKIVKNCRDEDTQKPSssSAPPDDDDLWLPPPEYVPLKELTGKKNMRNFCINGEVKVCSPNGYSFRILRHILRSFDEIYSGNHRMIGLVKVVIGLALSGAPVPEGMNWVYKLRRTLIFQWADSRGPLEGEELEYSQEITWDDDTEFVGLQIRVSARQCHIQGRlWCINMNSRACQLWSDMSLQTQRSEEDKDSSLLLE	0	0	0	0
+4140	PF03397	Rhabdo_matrix		Rhabdovirus matrix protein	Mifsud W	anon	Pfam-B_3980 (release 6.6)	Family	\N	25.00	25.00	166.50	166.30	18.10	17.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.91	0.71	-4.91	10	35	2009-09-10 23:57:29	2003-04-07 12:59:11	9	1	9	0	0	31	0	165.90	66	85.60	CHANGED	KRTILlPPPHLTSNDEDRVSTILTEGTLTITGPPPGNQVDKICMAMKLARAILCEDQHPAFNPLVHLFQSAMIFGETSEKIDFGTRSKTLITSFKlAEAKAIYLDoSPVRSRIEAKKYTTPIRHGSVTYYGPFlFADDHVGGKGHREKLGALCGFLQSssYGQAKDYY	.KRTlLIPPPHLhSsDE-RVollpsEGplplTGhpPosLpEKIhhuMpLAuAIlGGD.HPuFpshsaLFQptMEFGuTpEKlsFGoRcsss.ToapVh+A+tlYLpopPl-K+IshppYosshcsuoITaoGpFLFSusHVGscDsRsKLAuL-GFhpSsSYtpsKDYY	0	0	0	0
+4141	PF00945	Rhabdo_ncap	Rhabd_nucleocap;	Rhabdovirus nucleocapsid protein	Finn RD, Bateman A	anon	Pfam-B_477 (release 3.0)	Family	The Nucleocapsid (N) Protein is said to have a "tight" structure. The carboxyl end of the N-terminal domain possesses an RNA binding domain. Sequence alignments show 2 regions of reasonable conservation,  approx. 64-103 and 201-329 [1].  A whole functional protein is required  for encapsidation to take place [2].	19.70	19.70	20.30	20.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.15	0.70	-5.88	11	7911	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	119	82	36	2619	0	200.80	64	92.45	CHANGED	ssphVss+hPs.sDssEYPhsaFpcsp+phhshhps...hDLsphRphlhsGlpuuclssscVsSYLhtshcthcsphccDWsSaGlpIu+KG-pIs.hsLlslpcpcsp...h.cGtpcssRs...s-DtaLshhLLuLYRlu+sssp...sY+sslhD+lpp.hcst...phstcphl.sstchhssWsspsNFphlsuuhDMFFpRFcpHtauslRaGTlVoRYcDCuuLsohoahhKlhsLo.hc-shpWlFs+sht-Elh+MMp.PGQEIDsscSYhPYhhshGLSsKSPYSSsssPphashlHhlGshlsSsRShNAphlsstshpclossuhlluashtucushcppFhps-cchpptcsp-tsps-ss.scs.........spus-shsWhuhapchthphscphcsah+RhVpsls	............................................................................................................................YLhush..............................................................................................................................................................................................................................................................................................................................................ttc.h+.s...ch.t.sssu..............t.........hst-sps..uhYtch.hphsp.hh.tlp+hhts..o..........................................	1	8	8	36
+4142	PF03216	Rhabdo_ncap_2		Rhabdovirus nucleoprotein	Mifsud W	anon	Pfam-B_2146 (release 6.5)	Family	\N	20.20	20.20	20.30	20.60	19.90	20.10	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.11	0.70	-5.73	4	252	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	12	0	0	122	0	172.00	65	94.19	CHANGED	uul+cpFsGLRDVKssshtspGp-acPuclpLslYt..ossDhDhphIh+AlutVGGspTscALulLhAFVhttos.sth-stsKlLp-hGFpVcplPhusslpssltsP.pcLApslspENlh-lV+GlLaTCALhsKYsVDKMtpYhppKLtcLAoSQGlsELpphsss+usLt+luuslRPGQKlTKAlYuhILlpluDPsTtuRA+ALsAMRLsGTGMTMVGLFsQAAKNLGAsPADLLEDLCM+SlV-SARRIV+LMR.Vu-AcslpA+YAlMMSRMLG-uYFKuYGlN-NSRIosILhsINs+Ys-sThtGLpGlKVSs.FRcLAccIAclLVcKYDssGssGpGASDlIRpA	............................................................................DtKVIVDALSALGGPQTVQALSVLLSYVLQGNTQEDLtsKCKVLTDMGF+VTQusRATuI-AGIhMPMRELALTVNDDNLM-IVKGTLMTCSLLTKYSVDKMIK....................................................................................................................................................................................................................................	0	0	0	0
+4143	PF02484	Rhabdo_NV	Rhabd_NV; 	Rhabdovirus Non-virion protein	Mian N, Bateman A	anon	Pfam-B_2189 (release 5.4)	Family	Infectious hematopoietic necrosis virus (IHNV) is a member of the family Rhabdoviridae. The non-virion protein (NV) is coded for by one of the six genes of the IHNV genome [1], but is absent in vesiculovirus -like rhabdovirus [2].	25.00	25.00	72.90	201.70	18.40	16.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.35	0.71	-4.18	2	24	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	6	0	0	24	0	110.50	88	99.66	CHANGED	Msp+s.sTshtAL+-lLRYKspVAtHGFLFDDGclVWpE-sDtsWpRLhsVVsALhSSpRMppsLaMDhSITKG-GaLLFsDLQGTpNh.a+pP+FRpaLh.l--FLshPR	MDHRDINTNMEALREVLRYKNcVAGHGFLFDDGDLVWREEDDATWRRLCDVVNALISSKRMQRVLYMDLSITKGEGHLLFVDLQGTKNRLYKEPRFRRHLILIEDFLAYPR	0	0	0	0
+4144	PF00554	RHD		Rel homology domain (RHD)	Bateman A	anon	SCOP	Domain	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF01833) that binds to DNA.	19.70	19.70	19.70	20.30	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.95	0.71	-4.53	21	1068	2012-10-03 00:25:27	2003-04-07 12:59:11	17	44	147	75	369	1068	0	154.90	36	22.50	CHANGED	lcIlEQP+QRGhRFRYcCE.GRSsGSIPG.tpSpcssKTaPolclpsYpG.puh.lploLVT+-pP.h+PHP....HsLVGK...c.C+cG......hhplclsP-.shs.hsFpNLGIpCV+KK-lcpslppRh.............................phs.sPap.lt.pphcthpchDLNsVRLCFQsal..cpsGsashsLsPVlSsPIaDp	...............................LpIhtQPcp+.aRhRYpsE...sS.+Gul.u...........ps..ppsaPs.V.............c..lp....sYts....sh...lpl.lsTsst.....h+PHs....HclsGK..........s..s.p.p.s.................lh..cl..t..ltPc...shh..hshsshGIhpl+.pp-lptt.h.t..................................................phs..s.hp....................shVRLsFpsal......sps...shp.hh...lhSpPI.sp........................................................	0	51	81	191
+4145	PF02115	Rho_GDI		RHO protein GDP dissociation inhibitor	Mian N, Bateman A	anon	IPR000406	Domain	\N	22.70	22.70	22.90	22.80	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.22	0.71	-4.90	16	507	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	274	48	308	499	3	181.80	38	87.83	CHANGED	MuEppspstphpphttpp-c.p.tss.........YKPPspKSlcElhchDK-DESLpKYKEsLLGsss...slsDPssP.NVhVp+lsLLssstP.slphDLoG-..lcplKcps.FsLKEGscY+lKIsF+Vp+EIVSGL+YlppTaRtGl+VDKspaMlGSYuP+.s-....Y-ahTP.EEAPpGhLARGsYslKSpFTDDDKpsHLoWEWsLpIpK-	.................................................................ptp.t..........acss.sp..KolpE...h..ph............Dt-DESLp+aKcsL...L.Gtss...............sls-s.ssP..pV.h.l.ppLsLh.sp..st...P....sl..s..hDLss..s....l.pp.h...Kcps..FslKEG.spY+l+l.sFcV.p+-IVSGL+YlppshRpG...l+...V..DK......tp.......M......lG.S.Yu.P.....p..s-...........Yphhh...s.......E...EAPsG.hlAR.GsYsspSp......FsDDDcps....H.....L..pacWshpIpK-..............	0	79	153	234
+4146	PF00581	Rhodanese		Rhodanese-like domain	Bateman A	anon	MRC-LMB Genome group	Domain	Rhodanese has an internal duplication.  This Pfam represents a single copy of this duplicated domain.  The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.63	0.71	-3.73	147	30295	2009-09-13 10:52:53	2003-04-07 12:59:11	15	226	4760	191	9427	22860	9896	101.90	20	44.29	CHANGED	ssp..pltphh.......ttsshhllDlR........sttc..............................a..............pt..........u....HIsuA....l.slsh..................................t.......htphththspsp......tl..llas................tstpustssth.....hpt.....Gap.......pl.....hhlpGGhpsWttp	..................................................................t....h.thh.......ttsh...hllD....l.R.......................ss..t.-.............................................................................................................a.....................................pt...................G......H..l..s....G....A...........l.sls.h...............................................................pt......................h.t.p...h..h....t..............s...p..s.p.............................tl.........llaC.............................ttu..cus.t.sst.h............................Lpp..h........Gap..................................pl..................h...l......p.G.GhttWt..t..................................................................................	0	2977	5838	7876
+4147	PF00620	RhoGAP		RhoGAP domain	Ponting C, Schultz J, Bork P	anon	SMART	Domain	GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.75	0.71	-4.60	87	7538	2012-10-03 21:54:49	2003-04-07 12:59:11	22	300	353	36	4418	7012	27	147.00	25	17.80	CHANGED	Phllppslphlcp.pG..lppcGlaRhuGspsplppLppth-psts..........................thpptslpsluulLKpalRcLPcPLlshphapphh.t..shph.............tstppp.....................hptlppllp..pLPpsshpsLchLhtaLpclsp..psph............N+MsspNLAhlFuPsllps.t....tsp	.............................................................................................................Phhlppslp.h.l.cp...pG............l.p.p.c......Gla...R..l..s....G.s..t....s.....p.l..p..p.........L.c..p.t.hcpst.p..........................................................t.pt.hclps....l....u...u.....lL..K.....h..a.h....R....-..L..P.......c.........P.L.....l....sh...p...h...apphl..p.......shph...............................t.stpp.p................................................................................hptl.p.p..llp.......pL......P.....p.....s....s..h..p..s.L..p.h.Lh............p..aL..p..c......l.....sp........psp..................................NpMs.s.pNLAh.lauPsLhps......sst...........................................................................................................................	0	1311	1920	3077
+4148	PF00621	RhoGEF		RhoGEF domain	SMART	anon	Alignment kindly provided by SMART	Domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	20.90	20.90	21.00	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.45	0.71	-4.40	192	7395	2009-01-15 18:05:59	2003-04-07 12:59:11	15	583	301	68	4161	6705	27	174.70	22	17.10	CHANGED	llpEllpTEpsYlpsLphl..hphahpslpp..................................pshlstpc.........lp....t..lF.u.slpplhphp.pp.....h.LppLcp.................................................tp..........pp..................l.............uclF...lp.htp..............hhph.YspYsss...hspuhphl....pp..hp.............................................ppsp.........Fpp.......hlp.hpt.............ptht........LpshLlpPlQRls+Y.LL............Lccl.lKpT.s.t..sc........-h.p....sLpp........Alptl.pplspplNc	.............................................................................................htEllpTE.ppY...l.c.p....Lphl......hp.....h..ahpshpp.............................................................................................thl..s..t...pp..........hp......h.lF..s....N.l...p....p.lh....p.....h...p..pp.....h..L.p..p.....Lcp....................................................................................................................................t...tp..............tt.pp...................................l.............................us.ha.................lp...htp.......................hh.ph..YtpYsp..s..hs.p...u..h..ph.l.....pp.......ht.......................................................................................................................................................p.p.pt...................hpp............hh.p.p.hpt.....................................s..pphs...........Lp..s...h.L..l...p........P....l..QR............ls.+Y..LL..................................L....p..c.l...l+p..o....s....p....sp....................-t..p.........pl.p...p.........................Alphh.pplhpphN.....................................................................................................................................................................................................................	1	1275	1737	2801
+4149	PF03527	RHS		RHS protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.96	0.72	-4.18	18	2442	2009-01-15 18:05:59	2003-04-07 12:59:11	9	181	606	0	216	2289	23	39.60	54	4.56	CHANGED	laaYHsDphGtPLpLocs-GchsWpAcYcsWGslhpEpssp	.....lHhYHCDHRGL...PLALlSp-Gs....T....sWsAEYDEWGNhLsEEss..........	0	42	71	144
+4150	PF00073	Rhv	rhv; 	picornavirus capsid protein	Eddy SR	anon	Overington and HMM_iterative_training	Domain	CAUTION: This alignment is very weak.  It can not be generated by clustalw. If a representative set is used for a seed, many so-called members are not recognised.  The family should probably be split up into sub-families. Capsid proteins of picornaviruses. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids. They include rhinovirus (common cold) and poliovirus. Common structure is an 8-stranded beta sandwich. Variations (one or two extra strands) occur.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.07	0.71	-4.57	50	28435	2012-10-04 01:49:40	2003-04-07 12:59:11	15	90	713	302	0	21797	0	144.60	21	43.85	CHANGED	hsssspsshss.phsshhp........h.pppsssshpth....t...t.pphht.hpshshs.ttpshhhhphsh.spthph....h.......hGthhpaaoahRsuhcl.phh..h........su......oth......ppG.........p..........h.........l...l...sh....lPsGss...............................................sssst.................................hpuhhssH.hhshttssosplslPalussshpshh...........................................pa.sshshshhshssh.sh	......................................................................................................tst..s..ths...p..........tt..ps.h.th.......t.ts..................t..h.........s........................s...............t........................h.......h.s........a.p.l.sh...ht.hsp............htphhc.haTYhRh.DhEhshh...h...........ss.......................s..........t..........h..........hha..lP.sG..ss..........................................................................................ps...s...sp........hh..p...t...ts....sphslPahu..tphh...t.h.s.........................................h..................h.................................................................................................	1	0	0	0
+4151	PF02267	Rib_hydrolayse		ADP-ribosyl cyclase	Bateman A, Mian N	anon	Pfam-B_3719 (release 5.2)	Domain	ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose  hydrolase or CD38) synthesises cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.	25.00	25.00	45.70	37.20	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.78	0.70	-5.03	12	149	2012-10-02 19:28:18	2003-04-07 12:59:11	12	3	48	156	78	136	0	212.20	38	81.23	CHANGED	Tsphp-IhLGRChpYs.....thhpPt................tphsCpsIhcsFhpAhhsKsPCsls.pDYcshhpLsspo..lPssKolFWSpsp..plsHsasp.sppchhTLEDTLhGahuDsLsWCGp....tssSthsapsC...Pshpc....CsN..NshssFWppsSppaAcsAs..........................GlVpVMLNGSps..ss......asppShFuslElssLpss+VsplplaVhc-ht.....sssp-oCusuSltpLcphlps+shtasChss.+slhhLQClcpsppssC	...............................ph.plhluR.Chpah.......hpst....................t.phsCptlWcsF.ps...hh...s..K...s...PCslh.pDYp.h....hp.L...stps......lPpsKolFWppsp...lsppasp...sppc.hhsLpDs..LhGhhsDtL....sWCGp.....pss.sthsY.p.SC...Ps.pc....CpN....NslssFW+puS.tpaAcsus..........................GslpVhLNGShs..ss.......as.hpuhFushEl.sLp.pKVpplplaVhaplt.....s.s.s...h-oCupsSlp.LcphLpp.hshpaoChsshc.ssph.l.Chcpspp.tC.......................................	0	22	23	41
+4152	PF01872	RibD_C		RibD C-terminal domain	Enright A, Ouzounis C, Bateman A	anon	Enright A & Pfam-B_6425 (Release 8.0)	Family	The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C terminus of RibD/RibG Swiss:P25539, in combination with Pfam:PF00383, as well as in isolation in some archaebacterial proteins Swiss:P95872.  This family appears to be related to Pfam:PF00186.	20.50	20.50	20.50	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.29	0.71	-4.71	27	7001	2012-10-03 00:23:32	2003-04-07 12:59:11	12	23	4048	36	2265	6046	2900	188.90	22	66.43	CHANGED	salhhphshSLDGthusssGsuph....lsstt...............spthhpphRppssulllGt...sTVhs-sPthssphspt.............cpPh+lVlssphchs.psp......llsps....hhhhtt...............................h.sllcpLtpp.shpslhlEGGusLtsu.hlctGLlDclplhluPhllGu..utshhsstsh.t.....hplchtphpphusslhl	.............................................................................................................................hlhhphuhSLD.....Gh.hA......t....s..s.....u...p...s...p.....a.............l.o.s.tt.........................................sc.pt..s.p...p.h...R...s....p....s....sAl.l..h..Gt.................sT..h....h.....t....-....s.....P.....t.....h....s..s...c..h..tt..............................................ppP..h..+..l..V...l..s.p..p.....h..c.....h...s......s.tp.............................................lh....p....s....s............h..h..h..h....t...t................................................................h............................................h.s.ltp.hl.p.p.....L....t...pp.....s........h........psl..h.l....EG.Gs.....p..lss....s.hl.............p.......t....s....L.....lDElhlhlu..P.h.l...l.Gs........u.....hs..h..h.s..t.....s.ht...............phphhphp.hs.....h.................................................................	0	833	1564	1990
+4153	PF05062	RICH		RICH domain	Bateman A	anon	Pfam-B_277 (release 7.7)	Domain	This presumed domain is about 85 residues in length and very rich in charged residues, hence the name RICH (Rich In CHarged residues). It is found in secreted proteins such as PspC Swiss:Q9KK19, SpsA Swiss:O33742 and IgA FC receptor Swiss:P27951 from Streptococcus agalactiae. This domain could be involved in bacterial adherence or cell wall binding.	22.00	22.00	22.00	23.70	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.73	0.72	-3.85	26	495	2009-01-15 18:05:59	2003-04-07 12:59:11	7	33	170	0	1	455	0	74.10	40	17.91	CHANGED	spppcKttptVcpalcKhLs-l...pLcKc+HTQsVsLhpKLucIKpcYLhcLss.ppc............splpph.pcsKscLDAAF-pFKK	..............ppcKutptVspYhpKhLp-h...pLc+c+HpQsVuLlpcLssIKppYL.-lssspsK..........sphppLspKspu-lDAAhpcFKK........	0	1	1	1
+4154	PF01042	Ribonuc_L-PSP	DUF10;UPF0076; ribonuc_L-PSP; 	Endoribonuclease L-PSP	Bateman A, Finn RD, Kerrison ND	anon	Pfam-B_797 (release 3.0)	Domain	Endoribonuclease active on single-stranded mRNA.  Inhibits protein synthesis by cleavage of mRNA [1].  Previously thought to inhibit protein synthesis initiation [2]. This protein may also be involved in the regulation of purine biosynthesis [3]. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase [5]. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella [4].	27.30	27.30	27.30	27.30	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.45	0.71	-4.35	30	11334	2012-10-01 19:40:00	2003-04-07 12:59:11	16	61	4115	187	3227	8930	3544	116.70	29	81.61	CHANGED	otsAP..tshusYSp.Alp..ssshlalSGQlslcs....tssclh.sssstpQscpshpNlctlLptAGsshsc......lVKsTlFlsDhsc.FAplNplaspaFsps..........PARusVpVutLP...hsshlEIEslAhh	.....................................................s..ss.a..up...ulh..........hs.s..h.l..a.h.SG...Q...l..s..hs...............................s....sp...l..........s.....s...s.....l.......p.....t.....Q.....s......c....p....s....l...c.......N.......l...c....s....l....L........p....t..A....G...s.....s...h..sc......................l...l...+...so...l......a..l......s.........D...........h..s......c......F....s....s...h.N..........p...l...a...s...p.a...Fspt................................P..A..R....o.sVt.V...s.t..Ls.....sh.hlE.I-slAh.h.............................................................	0	905	1902	2685
+4155	PF00317	Ribonuc_red_lgN	ribonucleo_red; ribonuc_red_lg; 	Ribonucleotide reductase, all-alpha domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.61	0.72	-4.18	137	5796	2009-09-10 18:18:06	2003-04-07 12:59:11	16	66	4614	118	1297	4181	2797	77.40	30	10.10	CHANGED	hthshhuhp.hL.tpcYLh..+sp..ps.........hhEsspphahRlAhslAt.p..................................................................................sphphsp....caa....phhsphpahsuoPslhNAGpsts	.....................h..hoahuhp.ph.hspYhl.......+sp.......sG....p...........hhE.s..pphhhhVAhsLup............................................................................................schphAp......cha....chhsphca.p.sATPThhNuGpsp.p....................................................................................................................	0	412	816	1098
+4156	PF02867	Ribonuc_red_lgC	ribonuc_red_lgC; 	Ribonucleotide reductase, barrel domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	19.50	19.50	19.50	19.60	19.40	19.40	hmmbuild  -o /dev/null --hand HMM SEED	538	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.54	0.70	-5.95	136	8373	2012-10-01 23:28:04	2003-04-07 12:59:11	10	91	5010	124	2033	6508	10158	423.00	26	65.30	CHANGED	loSCFl........s.hsDol.....cuIhcshppsuhlpKtuGGlGlshop.lRspGu.lpussususGllshh+lhssssphlsQuG.pRpGAhslYLcsaHsDIh-FLs...hK.ppsuc-phR..........................................s+sl.hulhlsD..hFMc....tlcp.......stpWsLhsPpp..........................................l.phaGp.......capp.Y.ph...............................pps.......htc..plpA+cLappIhpsth-oGpPalhacDssNppssp.....p.............p.....h.........GpIpsSNLCsEIsp.tp..........................................................phusCNLuSlNLsphlpts............................................................................hshcplccslchssRhLsslIDhstaP.l.pscp............................sspcpRslGlGlhGLsshLhthtlsYsSp-AhphscplhEtltatAlcuShcLA.c.cpGsat...................sa..csStaupG....h.hchh..................................p............................................................................................WppL+ppltph.GlRNuhhhAlsPTuohS...ls.ssosulEPhhuplas+pshsst......h.hss..h.ptlpp..............h..t.ht.l.......................tsl.sh..tl.tphhth..ac.o.Aa.......-l...s.cthlchsAstptalDQu.Shslal................s..cs..ohpclpphahhAactGLKo.hYYh	.......................................................................hsSCal.........thtD..sh..............puI..h.ts.h.pp.hh.lsp.uuGlu...hthup......lRthGs.lp....s.h..p.s..usGhlsh.h.+.hhps........................sh.thssQh.............................G.h...........Rt.GA......h...........s.lalphaH.Dl.p.Fls...h+.ppp...u.pc.t.+..................................................................................................hpsh..shulh.l..s...c...hhhp.h...s.p.........stphh.L...hsP..p...........................................................................................t..h.................................thpt.Y......th...............................tp............h.h.p...pl.pA.pclaph.l.h.p..t.hpoG.Pal.hhhD......psNptss.........................................u......lp.....S..NLC..sEIh...t.............................................................p...hsCs..L.........u.........S.........hNlsthhp.......................................................................................ch.t.c.......hsphh..h....+h....L.....stl....h......D......h.....s......h..s......h...thpp............................ss...t.t+slGlGhh..shts.h...L.ht.tl.Ys....S.....p...u....h.phsphhh.hlthhshp..sS.plA..c..ct..s..s.a.......................a..p.t..o.....h..s..p....u.....h.........ph..ht..............................................t...............................................................................................WttLtt..tl..p...........Gh...h...Ns.h.Al.hP..o..sohS.....ls...........s.....s.o.s.ulc.P.hs...h.h.........+p..hpst...................................................................................................................................................................................................t...........h...h......a.p...s.sa..................ch...s.pthlchhu..hp.........p......alD.......Qu.Shsl.h................s....ph.......shppltphhhhAa.c.........h.G.....l.Ko.hYY....................................................................................................	0	708	1339	1729
+4157	PF00268	Ribonuc_red_sm	ribonuc_red; ribonuc_red_sm; 	Ribonucleotide reductase, small chain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.50	20.50	21.10	20.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.77	0.70	-5.40	13	7021	2012-10-01 21:25:29	2003-04-07 12:59:11	16	12	4393	189	1340	4104	4718	239.00	25	82.28	CHANGED	tshLpcstchF..ashcas-IhphhpcuhuspWhspElsLucDhpDhcp.LstsEppFhpalhAFhuAuDslVN.NL.schosphp.p-hcaaYs.QhuIEslHScsYShllpsLh.pDtpp+pphhsuIhspPsIpcKscWlhchls-scu.huE+llsFhhlEGIFFuuSFASIhaL+pRGLMsGls.oN-LISRDEulHTshAChlYsphh...c+Ps.chI....hclhpEAV-lEpcFlp...spsPsthhhhs...sctlpQYlcasADRLLsslGhstlassss..s.s.hs	..................................................hh.....................p....h.....p.h.app...h.s.p.aWhspc.ls..l..op.D.h.s.a.......p.........p.....L......sttE.pp.hhhpshs....hhshhD.o...l.s..p.s..h.......sl..h....h..p..h..s...c.......c..shhst..th...E.s.lHu....cuYohlhp.......s...........l............s.............s....................t...........t...............t.......h....a.......p.......h.....h...............p...................................................l...........p...c....+...........s............p...........h.............l...........................p.............h.............h.................t.............t.............t..............t...........h....................p............p...................................l.........u............s.....h.....l......Euhh....F.a.u..u....F.h.h....h.h...h............t..p.........p....s..h.....h.ss.uph.....h..chI.RDE.u.lH.h....h....h.h.t....h....h....h....p.........h....h....t....t.......p....p...........t.............p.....p....l...............hplhh...p....h....h.p.........E...h...p...asc...................h..h..s.t.......sh...........tp..h..ppalca.uspth.tlGhc..ha..sp.........s..................................................................................................................................................................	0	402	783	1091
+4158	PF00545	Ribonuclease	ribonuclease; 	ribonuclease	Bateman A	anon	SCOP	Domain	This enzyme hydrolyses RNA and oligoribonucleotides.	21.30	21.30	21.70	21.30	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.31	0.72	-3.91	80	855	2009-01-15 18:05:59	2003-04-07 12:59:11	15	18	696	335	302	839	28	88.20	33	48.99	CHANGED	LPspsp....pphshhptGhs.............sh.tpsGshFtNpEp......................hLPttssG....hYpEhsl.h.s....G.....sRGA..cRlVhusp...........uh.haaTsD.HYsoFpph	..................................................................................LPtphhpphphhptGhsh..................sh.spsGphFsNpEt......................................tLPptpsu........hY+EhsVth...s...................G......sRGu...cRllhuss.............uhhaaTsD...HYpoFpph........................	0	68	167	250
+4159	PF03631	Virul_fac_BrkB	Ribonuclease_BN;	Virulence factor BrkB	Bateman A, Eberhardt R	anon	Pfam-B_4424 (release 7.0)	Family	This family acts as a virulence factor. In Bordetella pertussis, Swiss:Q45339 is essential for resistance to complement-dependent killing by serum [1]. This family was originally predicted to be ribonuclease BN [2], but this prediction has since been shown to be incorrect [3].	25.60	25.60	25.60	25.80	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.98	0.70	-5.03	155	5654	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	3939	0	1383	3900	630	252.90	22	76.58	CHANGED	tpcchshhAuu.luaasllulhPhlhhhhulh.s........h....h...........thhpplhsh.......ltph...........................................hP.....t..sh.phlpshl.p.phh......pps.....................ttulluhuhll..........asusshhpslppuhNp....ha.............ph..pp.t+....s.........hl...ppphhshshh.l....hhsllllluhslsshhth..........................hhsh......h...hhphhph........lshhlh.hhh.hshlYphhPs.t..chphchsh.Gulluulhahlsphs...au.h.Ylsphs..sa.sshYG.ulu.ullllll..WlalsuhllLhGAplssshpptp	...............................t..pphsthAusluYaslLSlhPlLhlhhulh.u.h...hs................th.tpplh..sh......lhs.....................................................................lP........s..tss..shlpshl....p...p.l.t....sps................psu.l...l.ulshll...........aou.thhss.....lppul....Np....la......................cs...pc...pR....s.............hl...hphhhs.h....hhh..l....hhs.l.h.lh.h.ulslss..hhts.h.th..........................................hhsh..........th.......hhphl.ph......lshh.lh.hlh.ahhl.YhhlP....s...t.....+s................p.h.+t.s..l..hGuhluul.h.a...lh.p.hh...Fu..hYl.s.p.hs..........sh...sthYG...uhu..sl..l..ll..hl..WlahsshllLhGAtlsusht...h..............................	0	407	908	1180
+4160	PF00825	Ribonuclease_P		Ribonuclease P	Bateman A	anon	Pfam-B_1558 (release 2.1)	Family	\N	22.30	22.30	23.40	23.00	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.61	0.72	-4.17	141	4169	2012-10-03 01:04:38	2003-04-07 12:59:11	13	4	4132	9	899	2569	2063	107.70	28	88.95	CHANGED	h.s.+ptRLpppp-Fppla.ppup+.hts...pth..llh........htt..............................shsts..........................Rl..GlsluKKhup.AVpRNRlKRhlREsaRhppsp.ls.......uhDlVlls+.ps....ht..phshpplpp.........plpp...hhp+ht	..................................................pt.Rlpppp-Fptla....pp.u....p.....p....hu.s.....tp.h....llh...........hht......................................p......p.tps.......................................RlGloVuKK.hup.AVpRNRlKRhlRcs.hRh.t..p.p.p..ls..................shDhVl.lA+..ps...........st.....phsh..p.p.lpp.........sLp+.lhcp..t................................................	0	309	600	766
+4161	PF00445	Ribonuclease_T2	ribonuclease_T2; 	Ribonuclease T2 family	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.66	0.71	-4.68	116	3203	2009-01-15 18:05:59	2003-04-07 12:59:11	13	17	1368	27	551	2843	56	162.70	25	76.12	CHANGED	aD.........a.ahLs...........lpWsssaCt...................t......tpC........sttstsF.....slHGL.WPs..................p........ts.............h.sp.....C.........h........................slhsphpphWPsh.t.p.........shhpHEWpKHGTCus........................................tpsYFstshplh..pphsl.shLtpt..lhs.spstph.........shsplpsAlppss.....s..ttsslpCpp...................................hLpEltlChsps..............h...sCsp	..........................................................h.hs..pW.sshCt.....................................t........C................t.a.....TlHGL.WPs..............................................ths...t...................h..p.sCsss......hs......p.....................................................phhs.p.L...pp..hWPs...h.tsts..................phW.ctE..a.pKHGoCst.s.........................................t.tYFp.psh....phh................p.......ph......s.h.....phLtph......lhs...t..spph.......shpclt.sslppsh..........t...ttstl.pCpts.......................................................h.pl.hs.............................................................................	0	163	305	441
+4162	PF00687	Ribosomal_L1	L1; 	Ribosomal protein L1p/L10e family	Bateman A	anon	Pfam-B_115 (release 2.1)	Domain	This family includes prokaryotic L1 and eukaryotic L10.	21.70	21.70	21.80	21.80	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.64	0.70	-5.00	255	5940	2012-10-01 21:21:48	2003-04-07 12:59:11	16	17	4958	95	1878	3991	2982	212.10	38	87.56	CHANGED	lphlpp.....h.............................................t..ttcFscol-ltlsLph.........sppsspph...........psslsLP+.sht............+sh+.l...........sVhs.psp.ptp.......................pstthsuc.lluh--Ltpp........hc.pth....tcaDhhlAsschhshls.+..LGphL....us+GhhPsPh.....s.lsh.....................................s...lsptlcch+suphhhps.....+ss..slpstlGch..sh.sscclh-Nlpsllstlhph..t....hsKGh...l+slhlp..oTMusu	.........................................................................................................................................................th.hthttththht.................................................chs...psKFcp..o..V-.lulpL..sl........Ds++u..D..Q.pl................R..Gsl.........sLPp.GTG............+shRV................h.VFupG.scsctt...........................scs.A.GAD.hVGh--Lh.cp............lp.pGh......h.cFDlllAoPDh.Mt.hVG..+...LG+lL....................GP+GLM.PNPKs........GTVTh..................................................................DVscAV.c.csK.u.Gp...l.p.aRsD...........KsG.hlHssIGKl..oF...ss..........-cLhENhpuhlsslh+tK...Ps..........suKGh..Y..l+plslo.oTMGs.................................................................	0	649	1169	1576
+4163	PF00466	Ribosomal_L10	L10;	Ribosomal protein L10	Finn RD	anon	Prosite	Family	\N	22.00	22.00	22.20	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.06	0.72	-4.08	158	5754	2009-09-13 14:02:41	2003-04-07 12:59:11	15	11	4979	96	1716	3716	2281	98.80	30	50.84	CHANGED	hspppKpphl..pclpp..hlppsp.slhlsch....pGlsssphpplRppl.+ps...ssphpVsKNoLhchA...lcp.ssh................t........l.......p..s.hl...pGssulhao..pp-sss.ssKhlpca.K	......................................ppKpthV....scls-hh.......c.....s.......ut..usll..s.-h....c.GloV..sph..opLRcph.Rcs..............ssphcVs...KNTL..h++A....lct..ssh-.......................s................L.....s...c.hh....sG.Psu.ls.Fo....p-.-..ssu.sA+llpcFuK............................	0	591	1068	1434
+4165	PF00298	Ribosomal_L11	L11; 	Ribosomal protein L11, RNA binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.40	21.40	21.40	21.70	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-8.99	0.72	-3.83	171	5449	2009-09-13 02:34:37	2003-04-07 12:59:11	14	14	4897	169	1606	3179	2185	69.30	49	46.79	CHANGED	KTPPsohLL+KAAsl......c........+GSs..pP............s+pp.VGplohcQltEIAchKhs.DL....sussl-uAh+hlhGTA+SMGlpV	..............................................KTPPAu.sLLKKA.AGl.....c........+G.Su...cP.........................s+sK..VGp.lTpsQlpEI..........AcsKhs....DL.....sAs.slEuAh+hIt......GTARSMGlsV........	0	555	1012	1339
+4166	PF03946	Ribosomal_L11_N	L11; 	Ribosomal protein L11, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain of Ribosomal protein L11 adopts an  alpha/beta fold and is followed by the RNA binding C-terminal domain.	19.60	19.60	19.60	20.10	18.90	18.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.56	0.72	-4.51	167	5468	2009-01-15 18:05:59	2003-04-07 12:59:11	9	15	4889	114	1604	3175	2123	58.80	56	39.60	CHANGED	hlKLplsAGpAsPuPPlGPALGptGlNIhpFCKpFNspTpc....hp...Gh.lPVhITVas..D+SF	..........hlKLQlsAGpAsP....uPPVGPALGQ.pGl.N.....IM.cFCK...tFNA+T.pc................pt.Gh..IPVhITVYp.D+SF.................	0	555	1008	1337
+4167	PF00542	Ribosomal_L12	L12; 	Ribosomal protein L7/L12 C-terminal domain	Bateman A	anon	SCOP	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.08	0.72	-3.97	191	5164	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	4749	15	1334	3031	2145	67.20	57	51.44	CHANGED	EFDVlLsss..GspKIsVIKsV....Rs.lT.GLGLKEAK-LVEuA...Pps...lKEu..luK-EAEclKcpLE-AGA.pVElK	..................EFDVlLpuA...Gs....pKltVIKsV..........Rp.l.....T.GLGLK...EAK-LV-uA...Pp.s...lKEu..VuK.--A.EplKppLEEAGA.pVElK..........................	0	469	872	1139
+4168	PF00572	Ribosomal_L13	L13;	Ribosomal protein L13	Bateman A	anon	Prosite	Family	\N	21.10	21.10	21.30	21.70	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.59	0.71	-4.08	115	5540	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	4945	229	1626	3368	2257	124.90	46	81.05	CHANGED	WhllD..AcsplLGRLAoplAphLtGKp+s.apPt..hssGD..hVlVlNA-KlhlTG............pKh...pp+hYhph..oshsGuh+p.shpphhp.+..pPpcllc....+A......V+GMLP+..sphG+phhc+L+lYsGstHs.atst......pshtlph	..............WaVlD..Aps..ps.LGRLAoplAphLRGKpKspaT..PH..lDsGD..a.V.IVlNA-KltlTG............pKt...s.c.KhYY+H..osas.....G.GlKphoh.tchhp..+pPc+llE..........pAV+GML..P+....ssLGRthhc.KL...+..VYuGsEHs.HsAQpPpsl-.l......................................	1	568	1025	1367
+4169	PF01294	Ribosomal_L13e		Ribosomal protein L13e	Finn RD, Bateman A	anon	Prosite	Family	\N	24.90	24.90	25.90	25.00	21.80	24.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.11	0.71	-4.81	6	596	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	416	4	328	576	5	161.50	47	82.53	CHANGED	shIhpsHF+K+WQphVKTWFNQPARKsRRRtARptKAt+IuPRPsuGsLRPlV+sPTl+YNhKVRuGRGFoLEELKuAGIst+aA+TIGIAVDHRR+N+SlEuLQsNVQRLK-Y+uKLIlFPRcsp+s+ts-ussEEltpATQlpGshhPIpp.pt+plch+clocctKpapAFssLRht	.............................l.psHF+KcW......Q.......p......h.......V+saFsQPu.+K.hRRRpuR.tKAttluPR.P.s.s.......LRPlVRsP.T.l+.Y...N....p....K...lRsGRGF.oLp.ELK.uAGlst+hApTIGIuVDtRR+N...+...S.EuLp..tNVpRLK.p.Y+uK..Ll...lFP.+..+.s..p..t....s.+t.....G......D......u.....s..s...E....-.....l...t..h...A..............s.....p......h....p......s............h.hPltp......h.ht........c....h...hhloc....p.....c....thp..AatpLR.................................................................................	0	130	199	274
+4170	PF00238	Ribosomal_L14	L14; 	Ribosomal protein L14p/L23e	Finn RD	anon	Prosite	Domain	\N	23.60	23.60	24.00	23.60	22.70	23.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.89	0.71	-4.36	103	6114	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	5540	233	1569	3096	2117	119.80	57	97.21	CHANGED	MIphpohLpVuDNSGA........KplpCIp.Vl............st.p....ppphAslGDlIlloV.Kcu.................sscl+K....uplh+AVlVRs+Kt.h+.RtDGshlpF--NAsVlls..sp.s.p......PhGTRIh...GPVu+El.+..........pc.p........asKIsSLAspll	.....................................MIQ..pohLpVADNS...GA.............................................+clhCI+VL....GG.S............pR+aAslGDlIl..soV.KcA...hP.................pGpVKK....G-Vl+A..VlVRT.+Ks..hR..RsDGShI+FD-NAuVlls..sc..t.p.................PhGTRIF...GPVuRELR..........pc.p........FMKIlSLAPEVL...........................	0	520	978	1314
+4171	PF01929	Ribosomal_L14e		Ribosomal protein L14	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the eukaryotic ribosomal protein L14.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.50	0.72	-3.63	53	552	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	422	10	304	545	2	73.10	34	48.58	CHANGED	.RpshslpplpLTchplc.lsRsu+otsl+KAhcpuclppKWsposWAKKlss+cpRusLoDF-RFKlhhA.++pRsph	....Rpshsl+plpLTchtlc.ls..+uu+scsV+KAaccu.clppKWtposWAKKltspc+RuphoDF-RFKlhhsKptRp........................	1	106	170	248
+4173	PF00827	Ribosomal_L15e		Ribosomal L15	Bateman A	anon	Pfam-B_1567 (release 2.1)	Family	\N	21.70	21.70	21.90	22.50	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.07	0.71	-4.80	57	759	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	568	73	409	697	98	176.40	58	88.23	CHANGED	uhYpYlcEhW++.ppshh+hLh+.Rhhca...............Rp.sulhRlpRPTR.D+ARpLGYK.AKQGhllhRVRVRRGGR++shs+uup..+P+phGlsplps.s+slQtlAEERuuR+.hsNLcVLNSYWVGpDupYKaaEVILVDPpHsuI+sDsclsWIspssHKtRthRGLTSAG+KuRGLt.s+G.+tspKsR.sShRAs...a+	......................GAYKYlpE.La+KKQS.D.Vh.RFLhRlRsWpa..........................................RQh.sslpR.ssRPTRPDKARRLGYK.AK.QGaVlYRlRVRRGGRKRPVP.KGusYGKPpppG.VNpLKh.tRuLpulAEER.sGR+.husLR....VLNSYWVspDuoYKa..aEVILVDPtHpAIRpDPchsWIs.ps.V.HK.H.R.EhRGLTSAG+Ku.RGL..sKG.Htappsh..sS.pRtsW...........................	0	129	221	315
+4174	PF00252	Ribosomal_L16	L16;	Ribosomal protein L16p/L10e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	20.70	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.77	0.71	-4.40	141	7936	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	7072	230	1613	4271	2288	118.30	47	88.89	CHANGED	P++s...............KaRK......tp+..s+......h.pGtutt.........Gspls.aGc..............auLpuhEsu.hloucQlEAAR........huhsRhl................++...suc..........laIRl...FPcpslopKPh-sR.MGpGK.........GssctWsAhV+s.GpllFEl...s.G.l..s........phA+cAl+hAupKLPl+s..+hlt	..............................................PKRs.KaRK......pa+....G+....h.+Ghupt........................................Gspls..FGc..............auLpAl..Esu..hlTuR.QIEAAR.........hAhoRah..................................+R........sG+..........lWI+l..FPc+slTt+...shtsR.MGp..GK...................G..ss-hWVA.l.ps.G+ll.aEh.......sG.V..sc.........phA+EAhchAstKLPh+sphl.........................................	0	541	993	1334
+4175	PF01196	Ribosomal_L17		Ribosomal protein L17	Finn RD, Bateman A	anon	Prosite	Family	\N	20.20	20.20	20.50	20.50	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.29	0.72	-3.42	153	4802	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	4671	165	1229	2613	2175	101.60	51	72.16	CHANGED	hl.+NhssuLlp.............................+c+IpTThsKAKElRphsE+lIT.................lAK....c..................s.s...............................lpuRRp..shuhl.......................p...scp..................h....................................lpKLFsc........lus+Yts.RsGGYTRIlK.hu..RpG................................DsA.MAlIELV	..............................MLRNhssuLlp.............................HEpIpTThsKAKElRph.lE+..LIT...............................LuK....c.......................s..s............................................................................................lts..R..R....Ahu..hl........................+...scp..................s....................................VpKLF.s-..............luP.R.a.s.s..RsGGYTRIlK.sG...R.pG................................DsAPMAlIELV.............................................................	0	426	794	1042
+4176	PF00861	Ribosomal_L18p		Ribosomal L18p/L5e family	Bateman A	anon	Pfam-B_495 (release 3.0) & Pfam-B_741 (release 4.1)	Family	This family includes ribosomal proteins from the large subunit. This family includes L18 from bacteria and L5 from eukaryotes. It has been shown that the amino terminal 93 amino acids of Swiss:P09895 are necessary and sufficient to bind 5S rRNA in vitro [1]. Suggesting that the entire family has a function in rRNA binding.	27.80	27.80	27.90	27.90	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.24	0.71	-3.90	33	5752	2012-10-02 16:33:16	2003-04-07 12:59:11	17	13	5132	229	1513	3405	2152	116.10	39	83.74	CHANGED	scpctpp+++hhhp++hhssst+sRLlVh+SN+alhAQllssststslssASshst-Lpp..s.psshsNhsuAhtlGhLlAcRAlp........cGl.....................stlsaspsuhpYtGRVtAlAcuA+EuGLph	..............................pchtt.p.R.+tp.h.p.p.+...h......t.s...s.....t..p....sRLsVaR.Ss+cIYAQ........lIs...sssut..s..Ls..u.ASol.-.+.-lpp.......................................hs..h..ssh-AAttVGcllAcRAhp........................tGl..............................................ppVs.FD.R....u.G.a.h.Y.HG.R.VpAL...A-AAREuGLpF.....................................	0	490	947	1257
+4177	PF01245	Ribosomal_L19		Ribosomal protein L19	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	22.80	22.30	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.23	0.71	-4.29	127	4774	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	4673	153	1203	2595	2397	113.20	52	88.03	CHANGED	ts.llc...plEppph.....+..ps..lPpFcsGDTV+Vpl+lh.........E......Gs.........................+-RlQsFEGlVIu++s.t..Gl..spoFTVRKl.StGlGVERhFPlaSPtlcpI-VlR..+G............+VRRAKLYYLRs....hpGKuA.R.IKEch	......................................plIcpl-p..pQl.......+....p-.lPsF+...s..GDTVcVp.l+Vl.........E.Gs.........................+.cRlQ.sFEGV..VIu++s..t..Gl...spsFTV.RKI.S.s.G..l.G.VERsFPlHSPtl..-pIEVhR...+.G........................................c..VR..RAKLYYLRs....hpGKAA..R.IKEp.h...............................	0	415	776	1019
+4178	PF01280	Ribosomal_L19e		Ribosomal protein L19e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	29.00	29.00	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.79	0.71	-4.43	63	764	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	542	78	423	735	79	138.90	55	54.02	CHANGED	ssLphQKRLAAslLp......sGpsRVWl..DPpchs-lusAhoRpsIRcLIc-GhIhtKsh....................pupSRuRsRcpptp++.tGR++GhGpRKGspsAR.hspKphWhpRIRslRRhL+chR-stc.ID++hYRp...LYh+AKGspF+shppLhpalc.ptth.c	..............s.sL+hQKRLAAuVLp......CGcpKVWL...DPNEhsEIusANS.RpsIRK..LlKDGlII+KPs....................psHSRuRsRc...hptA++..KGRHpGhG...KR.KGTtsAR.hPp.......KhhWMRRhRlLRRLL+.+YR-ucK.ID+Hh.YHp...LYh+sKGNsFK.NKRhLhEaI++tKA-................	0	147	245	348
+4179	PF00181	Ribosomal_L2	L2;	Ribosomal Proteins L2, RNA binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	27.10	27.10	27.10	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.55	0.72	-4.01	50	6547	2012-10-03 20:18:03	2003-04-07 12:59:11	18	12	5878	241	1538	4221	2237	76.40	54	28.40	CHANGED	GRNsp.G+ITsR++GGGpKp.tYRhIDFpR.spts......l.uhVhsI-YDPsRsAhIALlpats...Gccp.....YILuspGLplGsplhu	.............................GRNsp..G+ITs.RH.pGG.G.HK+.tYRlIDFKR..sK.cs.............IsupVtpI....EYDPNR...oA.pIALl.p.YtD.....GEKR...........................YIlAPc.GlpsGsplh...................................	0	516	966	1289
+4180	PF00453	Ribosomal_L20	L20;	Ribosomal protein L20	Finn RD	anon	Prosite	Family	\N	24.10	24.10	25.20	25.00	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.37	0.72	-4.12	129	5432	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	5206	158	1102	2738	2165	104.60	52	89.30	CHANGED	sRV...KpG..sssRpR+KKlLKhAKGahGs+uphaRsApppVh+AhpYAYRDR+p+KR-FRpLWIsRINAAsRtpG...l..oYSpFlpuL+pusIp......lNRKhLA-lAlpDspuFspl	...................hRVKpG..ssuR.tR+K.KlLKh.AKGYhGu+pplaRsApptV.h+uhpYAYRDRRp+KRsFRpLWIsRINAAARtsG...............l...........SYS..+hhpGLK+A...sl-......lsRKhL.A-lAlpDtsAFssl....................................	0	386	724	933
+4181	PF01157	Ribosomal_L21e	L21e;	Ribosomal protein L21e	Finn RD, Bateman A	anon	Prosite	Family	\N	21.60	21.60	22.00	23.90	21.10	21.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.14	0.72	-4.20	6	896	2012-10-01 20:16:17	2003-04-07 12:59:11	13	6	529	75	505	859	81	94.60	51	64.65	CHANGED	spScGhRRtTRhhFpRcFRcHGlssloThl+pYKcGDhVcIKssuSlQKGMPHKtaHG+TGpVaNVs.uulGlhlNKcVpsphl.KRIplpsEHI+.Sc	...........po+GhRptTRhhFuR.sFR++.G..s.l.P.Lu.TYh..+hYKhGD....hVDIK...s........sGuVQK.GM.P.H.KhYHGKTG.cVaNV..Tpc.AVGlll.NKpVps....+hlt.KRIs.VRlEHl+cS.................................	0	137	228	326
+4182	PF00829	Ribosomal_L21p		Ribosomal prokaryotic L21 protein	Bateman A	anon	Pfam-B_1297 (release 2.1)	Family	\N	21.10	21.10	21.10	21.10	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.94	0.72	-3.86	67	4725	2009-01-15 18:05:59	2003-04-07 12:59:11	16	12	4593	156	1157	2545	2044	95.10	44	82.00	CHANGED	MYAllcoGGKQa+VptGchlhlEKl.ss.csGsplphscVLhluss.tpsplGpPhlcG..ApVpAcVlpc.s+ucKlhlaKa+p+Kph+++pGHRQ.aTcl	...................................MYAllco.GGK..Qa+VptGphlh.l.E......KL......ss......c......s............G.......pp.lpF..s..c..VLhVuss.......p.lplGs.P.h..V..sG...ApVsAc.Vlpp....G+.u.c..KlhlaKa+.p.+Kp.h.++.+pG.HRQ.aTcl....................	0	416	764	986
+4183	PF00237	Ribosomal_L22	L22; 	Ribosomal protein L22p/L17e	Finn RD	anon	Prosite	Domain	This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.	20.10	20.10	20.30	20.40	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.24	0.72	-4.09	126	6446	2009-01-15 18:05:59	2003-04-07 12:59:11	14	18	5594	236	1745	3781	2204	106.90	41	78.62	CHANGED	Aht..+tl+lSscKsphlschIRGpslpcAlshLchs....................................................sc+uuphlhKlLcSAhANA..p.....psps.h-.s-pLhlpclhlscGsphK.RhpPRApGRAs.lpKcssHlpllls-	.....................................Aht+tlRhSs..pK.s.RhVsDhIR..G......+pls..cAl.slLpas.........................................................P.c.+.A.Athl....tK.lL..pSAl.A.NA...E.............................pNtu...hD....hc....s..LhV..........scsaVs.c.G.s........s.......h.K..Rh.pP..RA....+G...RAstIp..KcTuHITllVs.......................................................	0	576	1053	1415
+4184	PF01776	Ribosomal_L22e		Ribosomal L22e protein family	Bateman A	anon	PSI-BLAST P56628	Family	\N	23.30	23.30	23.70	24.20	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.55	0.71	-4.06	35	584	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	350	6	314	534	5	110.50	52	81.65	CHANGED	p.KK...ssh....KFslDCopPsEDs.IhD...lusF......E+aL+-RIKVsGK...........sGNL.G.....ssVsls+p.csKlsVsoclsFSKRYLKYL........TKKYLKKssLRDWLRVVAo..sKssYELRYFpl.spsp-----	......................t.pK.sh+FslDCopPVEDs.IhD...su.sF......EpFLp-RIKV.s.G.K...........sGNL..G......s.s.V.sl.p+p..KsKIs..Vs.S..-......h.s...F.S.KRYLKYL...........TKKY.LKKps......LRDWLRVVA.s..sK..s..sYELRYFpI.sp---E--.c......................	0	100	168	246
+4185	PF00276	Ribosomal_L23	L23;	Ribosomal protein L23	Finn RD	anon	Prosite	Family	\N	21.10	21.10	21.20	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.83	0.72	-4.04	12	6180	2012-10-02 20:46:34	2003-04-07 12:59:11	15	12	5417	233	1734	3501	2091	88.90	36	80.46	CHANGED	hcll+hPllT-K.shphhcp.NphsFhVshcusKhclKcslcplasV+VhsVNThlh.sKhhR...Gph..hhp..hKKAhlpLp.cs.pthshhsch	.....................................h.cllhtPll.TEK..uhth............h.........-.c.......s......ph.sFpVsh...cA.sKspIKpAVE.pl.F...s.....V..c..VtsVN.T.hs...........h....p....u.....K.....h........K.......R........hG.....p........h.....h....G......p............p..t..c...hKKAhV.oLp.tG..ppl.h...t..................................................	0	536	997	1350
+4186	PF03939	Ribosomal_L23eN		Ribosomal protein L23, N-terminal domain	Finn RD	anon	DOMO_DM01622	Family	The N-terminal domain appears to be specific to the  eukaryotic ribosomal proteins L25, L23, and L23a.	20.50	20.50	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.78	0.72	-3.94	47	612	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	318	8	359	542	1	56.00	52	33.22	CHANGED	tss..ts+AtpA.............pKAllKG..spu.........p+p.+KlRTSspF+..................RPKTL+hsRsPKYPR+SsPcp	.........................................................................................s.pspuKAhKA........pKAVlKG...sau......................+Kt..+K.lRTSsTF+..................RPKTL+LpR.pPKYPRKSsP+..............	0	80	141	211
+4187	PF01246	Ribosomal_L24e		Ribosomal protein L24e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.80	20.80	20.80	20.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.37	0.72	-4.12	7	1060	2012-10-03 05:12:49	2003-04-07 12:59:11	15	10	541	76	653	956	68	67.60	43	44.21	CHANGED	h+schCpFsGtcIYPG+GhhFlRsDupVFhFtsSKCcp.F+.++pPR+lsWTshYR+pHtKs.stEstccp	...............M+hchCtFsutpIYPG+Ghh.aV.....R....sD.uKlFpFp.sSKC.c.ps.F.p.h+....+NPRKlpWTthaR+tptKths.c......................................	0	228	377	537
+4188	PF01386	Ribosomal_L25p		Ribosomal L25p family	Bateman A	anon	[1]	Domain	Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis Swiss:P14194, which is induced by stress.	21.50	21.50	21.60	21.90	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.86	0.72	-3.86	184	3556	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	3478	158	851	2159	2048	87.40	33	49.38	CHANGED	LpAphRp....p..hG.KuuuR+LR+.pGtlPAVlYGts.pc.s.....hslslstpcltchl....ptshtssl.lsLp.lc....G......pp.tpsll+-lQhcPlps.plhHlDF	............lpuphRp.....p..hG..KuAuR+LRc.sG.plPAllYGts..pp..s........................lslplcppclhphlt...ptt...h...h....s.s.l.lsl.s.l.c.G...........cp.hp.Vllp-lQhcPh.+s.plhHlDF................	0	295	572	730
+4189	PF01016	Ribosomal_L27		Ribosomal L27 protein	Bateman A	anon	Pfam-B_1340 (release 3.0)	Family	\N	20.50	20.50	20.80	21.10	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.54	0.72	-4.19	88	4787	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	4661	166	1215	2396	1851	80.80	60	81.70	CHANGED	AHKKuuG.So+N.GRDSpuKRLGVK+aGGphVpuGsIIlRQRGT+hHPGpNVGhG+DaTLFALh-GhVcFppp......pp...++hVsVh	...................AHKKuuG.ST+N.GRD.SpuKRLGVK+aG...GphVpAGsIIlRQ.R.............G.............T...+hHPG.sN.....VGhG.+D.cT....LFAhsDGhV+FcpK........s+s...RKhVSV..........................	1	418	783	1027
+4190	PF01777	Ribosomal_L27e		Ribosomal L27e protein family	Finn RD, Bateman A	anon	PSI-BLAST P51419	Family	The N-terminal region of the eukaryotic ribosomal L27 has the KOW motif.  C-terminal region is represented by this family. 	22.60	22.60	23.50	22.90	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.14	0.72	-3.86	42	533	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	381	6	297	498	5	82.70	49	58.62	CHANGED	KVTK+MuK++ltKRS+lKPFlKllNYNHLMPTRYol.Dl..t.Ksl......ls..p-sh+-ssp+ccA++pl+ttFE...ERa..........KsGKN+WFF.pKLRF	...................KVT+pMuKKKlsKRSK.lKsF..lKllNYNHLMPTR..........Yol.Dl......Ksl........ls..p-sh+-ssp..+..c....cA++p.....sKtt.hEERY............csGKN+WFF.pKLRF....................................................	0	107	164	238
+4191	PF00830	Ribosomal_L28		Ribosomal L28 family	Bateman A	anon	Pfam-B_1561 (release 2.1)	Family	The ribosomal 28 family includes L28 proteins from bacteria and chloroplasts.  The L24 protein from yeast Swiss:P36525 also contains a region of similarity to prokaryotic L28 proteins.  L24 from yeast is also found in the large ribosomal subunit	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.65	0.72	-4.14	114	4841	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	4485	146	1176	2313	1891	59.80	39	73.86	CHANGED	+c.CplTGKpshh.GNsVS.............H..upp......+T+RpatPNLppp+lassp.schl+l+los+sL+o..lcKpG	........................+hCplTG.Kpshs.GNs.hS..............H..upN.............pTKR+ahPNLpphRhhl.-...s...+h.h.+.l..pVSs+uL+s...lpt..............	0	402	770	1005
+4192	PF01778	Ribosomal_L28e		Ribosomal L28e protein family	Bateman A	anon	PSI-BLAST P17702	Family	\N	21.60	21.60	22.10	22.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.56	0.71	-3.69	67	772	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	384	5	475	736	4	113.20	30	53.54	CHANGED	LhWpll..+psss.FhhKpp.......stpFop-shNlsshsoh+asG...................................Lsss+slsl..pss..sG....tlhlshKps...cpsppPu.+thpp.....hplsp..sh+cuhcplcphhpt.....aRt-Ltpt...uhpRhot.............lhpst	...........llWpll..pps..s.F...h.lKp.p...........sppFs+.......p.hNlsulsshp.ss...................................LuNs.+hssl...pts...pG..................slhlh.h.Kph...ccsp..tPu...+h....ap+..............splsc...shc+slpplccplth...........apt.Lt.pt.....shpRhotlhp..h......................	0	169	262	389
+4193	PF00831	Ribosomal_L29		Ribosomal L29 protein	Bateman A	anon	Pfam-B_1296 (release 2.1)	Family	\N	24.50	24.50	24.50	24.60	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.53	0.72	-4.28	156	5085	2012-10-02 11:59:50	2003-04-07 12:59:11	18	7	4872	242	1354	2614	1785	57.70	41	77.08	CHANGED	spElRphos.cELpcclt-L+pELhpLRhppus.Gpl..ppsscl+plR+sIARlhTlls-+	................hpELRphos.-ELppc...LtpL...KcELFsLR..hQtAT...GQL..ppsscl+pVR+sIARl+TllpE+.............	0	475	879	1141
+4194	PF01779	Ribosomal_L29e		Ribosomal L29e protein family	Bateman A	anon	PSI-BLAST Q24154	Family	\N	20.70	20.70	21.30	25.30	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.16	0.72	-4.09	30	523	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	333	6	267	471	3	39.40	67	40.99	CHANGED	KSKNHTsHNQ.N+KAHRNGIKKP+c..pRa.ShKGhDsKFL+N	.........KSKNHTsHNQ.o+KsHRNG.I.KKP+s...pRY.....t.SLK..G.lDPK..FLRN...........	0	77	129	188
+4195	PF03947	Ribosomal_L2_C	L2;	Ribosomal Proteins L2, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.50	21.50	21.70	21.90	21.10	21.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.54	0.71	-4.34	58	6875	2012-10-01 20:16:17	2003-04-07 12:59:11	13	12	6045	240	1601	4450	2557	124.70	56	47.82	CHANGED	lchGNslPLppIPlGThlHNlEhpPGcGGplsRoAGohAplluKps..p.ashl+LPSGEh.+hlpppC....hATIGtVuNhsppphslG.KAG+sRWhGh.....RPpVRGVAMNPVDHPHGGGEG+sthGR.psVoPWGpP	..............................IKsGNsLPLp....sIPlGTslHNlEl+P........G..+GG.......Q.lARoA..........Gs.AQ..........llu.......+...........-G................pYsplRLsSGEh.Rhl.ssC.........+A........TlGpVGNsp.+.t..h..slG.KAGpsRWhGh.....................RP.sVRGss.MNPVDHPHGG.GEG+ss..h....G..R....p...PsoPWGh...................................	0	533	1001	1341
+4196	PF00297	Ribosomal_L3	L3;	Ribosomal protein L3	Finn RD	anon	Prosite	Family	\N	26.50	26.50	26.80	26.80	26.40	25.20	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.72	0.70	-4.99	13	5795	2009-09-16 22:34:17	2003-04-07 12:59:11	17	16	5080	235	1672	3675	2404	198.80	40	84.21	CHANGED	KsGMTplh.........scs.tss.sVTllEssPssVltlpshs...............................................s-GhpulplshpphKcppsshplluHhphtsss....tKtalhEhplssu..........cpaE..pslsV.slFppsEhlDVtGlTKGKGFpGshKRWGhp+hPtpHupu..+R+lGslGA.hcPuRVhhosthsGphG.c+RT.hNhKIh+lss......................................csshlhlKGuVPGs+pplVpl+	..........................................................................................KlGMTplF.............scs.G.hlP.VTVl-ss.s...shVsQ..l+oh-................................................................................................................................sD...G.Y...p....A..l..Q..l...s...h...s....s.....h........+........t.....p..p........s........s..K...P.....t........G...H......htKAss...................t..................spRhlh.E...h+.hsss............................pthp.l.Gp..plsl.-l.FtsGc.hVD.VoGsSKGKGFt.........GslKRasFpt.t.s.t...o.H.G.sph....HR.psGSl....Gs...tts..P....uR.VFKG++MAG+MG.sc+..VT..l.QNLcV.l.+VDs...............................................................EcsllLlKG.u.V.PGsptuhlhl+...................................	0	600	1058	1399
+4197	PF00327	Ribosomal_L30	L30;	Ribosomal protein L30p/L7e	Finn RD	anon	Prosite	Domain	This family includes prokaryotic L30 and eukaryotic L7.	22.40	22.40	22.40	22.50	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.32	0.72	-4.37	115	5033	2009-01-15 18:05:59	2003-04-07 12:59:11	15	10	4388	240	1490	2792	891	51.90	37	54.41	CHANGED	tlplshl+u.hl...utt.cp+pslcsLGL++lspsVhhcsoP.slp.........GMl.pcVpaLV	.....................l+lThh+S.sI....Gp..pp+tT....l.puLGL+...+lspo...Vhh.c.D.s.P.ulR.............GMlppVpahV....................	0	474	898	1215
+4198	PF01197	Ribosomal_L31		Ribosomal protein L31	Finn RD, Bateman A	anon	Prosite	Family	\N	21.80	21.80	22.20	22.70	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.37	0.72	-3.98	163	5588	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	4410	108	1124	2737	1977	73.20	45	92.06	CHANGED	M.KpsIHPc.Yppl.shpss.sGspFhopSTh...............pt..l...pl-lsSps..HPFYTG.c.p+h.lDosGRV-+Fp++a.utt	..................................M.Kp..sIHPc.Y+.p.l.sh.pso.sG..ptFhotSTh.................shshl...pl-lsSps..HPFYTG...+....Q+h..ls.s.sGRV-+Fp+RaGh.h...............	0	368	722	947
+4199	PF01198	Ribosomal_L31e		Ribosomal protein L31e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	26.10	25.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.60	0.72	-4.31	59	847	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	531	78	443	768	76	81.00	49	67.39	CHANGED	pcllTR-hTIsL++th+tsshKKRAP+AlKpIRcFsp+pMtTc..DVRlDscLNctlWu+GI+ssPtRlRVRluR+cs-p-suppc	.....................................-VVTREYTIs.lHK+.lHGl..............sFK.KRAPR.AlKEI+KFAtKpMGTs..DV.RlD.s.cLNKtlWu+GI....+.s.VPhRl.RVRloR+.RN--.E-u.p......................	0	137	224	315
+4200	PF01655	Ribosomal_L32e		Ribosomal protein L32	Bateman A	anon	Pfam-B_1346 (release 4.1)	Family	This family includes ribosomal protein L32 from eukaryotes and archaebacteria.	25.00	25.00	26.20	25.80	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.22	0.72	-4.01	75	903	2009-01-15 18:05:59	2003-04-07 12:59:11	13	11	637	76	442	805	68	103.50	53	78.33	CHANGED	+ph+FpRapSc+ap.Rlss..sWRKP+G.lDs+lRR+a+Gphh...hPpIGYGSs+csRtlhPS..GacchLVpNlc-L-hL......pscshAucIApsVuu+KRhpIl.c+ApcLul+VhNs	..................+sK+FhRHpSDRah.+lpp..sWRKP+G.IDsRVRR.RF..K.Gp.hh...MPsIGYGSsK+TR......HhlPo..GF+..+F.LVHNV.+-LEhL....hM.pN.+sasAE......IAHsVSu+KRptIl.cRA.tpLul+VsN.........................	0	133	228	323
+4201	PF01783	Ribosomal_L32p		Ribosomal L32p protein family	Bateman A	anon	PSI-BLAST P31558	Family	\N	21.20	21.20	21.20	21.30	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.89	0.72	-3.79	171	5348	2012-10-03 10:42:43	2003-04-07 12:59:11	18	14	4994	161	1126	2495	1357	53.90	34	82.85	CHANGED	AVPK++sS+o++chRRup.h.....plpss.sl................s.ssp..su.phplsHplssss.G..aYps+plhpt	...............AVPp++sS+o..++shR.Ro..+.h......pl.sss..sl................s.s.s..sG..-.....h.+.lsH...+...lshs...G.....hYpG+plh.............................................	0	378	726	946
+4202	PF00471	Ribosomal_L33	L33; 	Ribosomal protein L33	Finn RD	anon	Prosite	Family	\N	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.48	0.72	-3.72	117	6317	2009-01-15 18:05:59	2003-04-07 12:59:11	15	6	4846	154	1214	2452	978	49.00	45	90.31	CHANGED	R...htlpLt..Cop..............sssppYsTsKN++spsc+LEl+KaCs........hspKHTlH+EtK	....................R.pIpLt..sot........................sss+pYhTsK..N..+..R..N..s.P-RLE..lKKasP........hs+KHsla+EsK............	0	417	791	1027
+4203	PF00468	Ribosomal_L34	L34; 	Ribosomal protein L34	Finn RD	anon	Prosite	Family	\N	25.00	25.00	30.30	33.30	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.21	0.72	-4.28	143	4214	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	4149	154	1033	1670	249	43.90	63	86.81	CHANGED	hKR.TaQPoph+RpRsHGFRuRMp.T+sGRcVLppRRtKGR+cLos	............MKR.Ta.Q.Poph.+RpRsHGFRsRMu.T+sGRpVLApRRsKGRKpLos....	0	353	675	875
+4204	PF01199	Ribosomal_L34e		Ribosomal protein L34e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.60	20.60	21.50	21.40	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.21	0.72	-3.76	52	630	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	462	6	352	585	12	89.50	47	77.16	CHANGED	Ms...+lhh....++R.sYpT+SN+++hs+TPG..G+lVhpahKKpsshP+..CupCtph..LpGl.thRstchp+..hsKpp+pVsRsYGGshCspCl+c+Il+AFL	...............Ms..p.RlTaRRR..sYsT+SN+pRll+T.PG..G+LVh.ahKKpussPK..CGs..C.st+..LpGl.......slRPp.chtp..lS..+scKoVsRsYGGshCupCV+-..R..IlRAFL................................................	0	122	194	280
+4205	PF01247	Ribosomal_L35Ae		Ribosomal protein L35Ae	Finn RD, Bateman A	anon	Prosite	Family	\N	21.00	21.00	21.00	29.10	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.25	0.72	-4.21	44	533	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	374	8	317	528	13	93.90	51	77.29	CHANGED	LY..sKulahGY+Rup+NQppssuLlKIEGVss+c-upFYlGKRlsYVY+uppppp.........t.o+hRsI.WGKloRsHGNSG....sVRA+F+.pNLPspAh.GpplRlh	....................LasKuhahGY+Ruh+NQp.pT.uLlKIEGVps+c-sp.FYlGKRs.AYVY+A+pp..pp.....................so+hRsI.WGKVTRsHGN..SG....sVRAKF+.pNLPs+uhGtplRVh....................	0	112	169	243
+4206	PF01632	Ribosomal_L35p		Ribosomal protein L35	Bateman A	anon	Pfam-B_1156 (release 4.1)	Family	\N	22.20	22.20	22.30	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.95	0.72	-4.07	22	4520	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	4430	154	1091	2113	1842	60.70	44	86.05	CHANGED	sKhKTp+uusKRFKtTusG.thhRc+As+pHlLtKKosp+K.R+Lcppshlsps-sctlcthL	............PKhKT++uAAKRFKhTuoG.plK.Rp+Ahp..pH....lLs..+..K.....osKpK.R.....pLR.tssh.V..s.p.uDh.cpl+phL..............................	0	376	708	922
+4207	PF00444	Ribosomal_L36	L36;	Ribosomal protein L36	Finn RD	anon	Prosite	Domain	\N	21.70	21.70	22.00	21.80	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.90	0.72	-3.97	108	5148	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	4407	121	1073	1688	153	38.20	58	90.83	CHANGED	MKVRuSl...K+hCcsC+llRR+......G+lhVIC.ssP+HKQRQG	......MKVRsSV...Kp...h.C..ccC+ll.+R+......G+lhVIC....sNP+HKQ.RQG...	0	360	686	906
+4208	PF01158	Ribosomal_L36e	L36e; 	Ribosomal protein L36e	Finn RD, Bateman A	anon	Prosite	Family	\N	19.40	19.40	19.90	20.30	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.33	0.72	-4.06	39	534	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	365	6	288	505	4	94.80	52	79.12	CHANGED	ss+...slsVG..LNKGHpsT+...........p.ppsRsS++...KGhhoK+s+hVR-llREVsGaAPYE+RshELLKluKD...KRALKFtKKRLGTHhRAK+KREEhpslltt..RKt	..................h.+.slsVG..LNKGHp.sT+...............ps.tsR.S+p............KG.thoK+o+FVR.-llREVsG.aAPYE+Rs.hELLKloKD...KRALKhhKK.R.L..GTHhRAK+K.+EEhsslltt.R+.....................	1	97	156	230
+4209	PF01780	Ribosomal_L37ae		Ribosomal L37ae protein family	Bateman A	anon	PSI-BLAST P54051	Family	This ribosomal protein is found in archaebacteria and eukaryotes. It contains four conserved cysteine residues that may bind to zinc.	21.90	21.90	21.90	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.22	0.72	-4.12	55	636	2012-10-03 10:42:43	2003-04-07 12:59:11	14	4	512	74	373	557	67	86.00	53	92.54	CHANGED	s+RTKKVGlsG+aGsRYGuoLRKpV+clElpQ+u+YsCsaCG+pu.VKRpusGIWpC..+pCscshAGGAYsssTsuutos+psIcRl.cchp-	..............KRTKKV.GIsGKYGTRYGASLRKhVKKhEloQ...Hu+YsC..sFCGKss.lKRp.uVGI.WpC..cpCt..+slAGGAashsTsuAsol+S.slRRL.+-...p...................	0	127	212	300
+4210	PF01781	Ribosomal_L38e		Ribosomal L38e protein family	Bateman A	anon	PSI-BLAST P23411	Family	\N	21.00	21.00	21.20	21.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.30	0.72	-4.22	26	458	2009-09-10 15:39:13	2003-04-07 12:59:11	13	5	349	6	280	401	2	68.40	56	82.79	CHANGED	P+pIpDIK-FLphsR.RpDA+...Sl+IK......Kssps.....TKFKVRCS+YLYTLVVsDpcKAcKLcQSLPPsLplp-l	....................................P+pIp-IK-FLhhAR..R..KD.A+.....SV+IK...........KNpcs............lKFKVRCSRYLYTLVlp.Dp-KA-K.LKQSLPPuLpVp-l...............	1	97	156	225
+4211	PF00832	Ribosomal_L39		Ribosomal L39 protein	Bateman A	anon	Pfam-B_1293 (release 2.1)	Family	\N	21.60	21.60	21.80	24.60	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.05	0.72	-4.49	44	553	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	446	76	309	534	23	42.30	60	75.51	CHANGED	pKhRLAKAhKQNR.lPtWlhlKTsp+lchNsKRRaWRRo+LKl	...hKp+LAKttKQNRPlPpWlRh+TsNpIRYNuKRRHWRRTKLt........	0	101	179	245
+4212	PF00573	Ribosomal_L4	L1e; Ribosomal_L1e;	Ribosomal protein L4/L1 family	Bateman A	anon	Prosite	Family	This family includes Ribosomal L4/L1 from eukaryotes and archaebacteria and L4 from eubacteria. L4 from yeast has been shown to bind rRNA [1].	20.80	20.80	21.20	20.80	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.01	0.71	-4.91	165	5579	2009-01-15 18:05:59	2003-04-07 12:59:11	17	12	4937	231	1620	3471	2695	191.40	36	83.57	CHANGED	lpL...ssplFsh.....ph.ppsll+psVht.hus.................pRpGTtssK.sRu-VsG....us+KPa+QKGTGpARtGoh+..............uPha+GGGhsaGP+P.R.sash.+lN+K..........h++hAl+oALotpsps.splhll-.....s..h.p..lp............psK......................TKphhphLps.................lph............................p.............psLllss........p................sp.................................slhhuuRNlssV.clhsspp.....................lNlhcllptcp....lllTcsAlcp.lpch	........................................pLscslFu.h..-.h...Nps..llapsVhs.hAs...........tRQGT+.ssK..sR....u-..VoG....uG.+...KPa+QKGTG.RA....RpGolR..............uP.aRGGG.h.sF.uPpP..R..sa.u..h.KlsKK.........................h+RhAl+SsLSp.....pspp.sp.l.hll-.............sh..s...hp..........................sPK......................................TKp..h.sph..L.ps......................lsl.........................................c...cs..L.llss...................c...............hc..c.........................................................slh...LuuRN..l....s..s.....V....cVhs..s.s.s.....................lsshsllstcc....llhTpsAlcplEE.h.........................................................................	0	573	1032	1366
+4213	PF01020	Ribosomal_L40e		Ribosomal L40e family	Bateman A	anon	Pfam-B_884 (release 3.0)	Family	Bovine L40 has been identified as a secondary RNA binding protein [1]. L40 is fused to a ubiquitin protein [2].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.75	0.72	-4.37	3	580	2009-09-11 04:53:38	2003-04-07 12:59:11	12	14	450	7	314	466	8	48.80	64	40.21	CHANGED	VMEPTLsALAKKYNCEKKVCR+CYARLPPRATNCRKKKCGHSNsLRhKKKLK	.............l.IEPSLp.LApKYNC-KhICRKCYARL.PRAoNCRK+.KCGHoNpLRPKKKlK.........	0	93	167	254
+4214	PF05162	Ribosomal_L41		Ribosomal protein L41	Wood V	anon	Wood V	Family	\N	22.30	22.30	23.10	23.10	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.82	0.72	-7.02	0.72	-4.27	3	137	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	118	2	61	85	2	24.80	85	51.88	CHANGED	MRuKWKKKRMRRLKRKRRKMRQRSK	..MRAKWRKKRhRRLKRKRRKMRtRSK....	0	22	33	49
+4215	PF00935	Ribosomal_L44	L44;	Ribosomal protein L44	Finn RD, Bateman A	anon	Pfam-B_1065 (release 3.0)	Family	\N	25.00	25.00	26.30	28.60	23.70	22.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.73	0.72	-3.97	44	678	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	513	75	382	617	73	76.10	56	65.83	CHANGED	pHo.HcVspYK.pGKtothupGcRRacR..+ppGaGGpp+Pl.c+.uKs......TKKlsL+hcCspC+ptphpsh..hRsK+FElsp	..........KHp.HKVTQYK..pGKsShhAQ.GK.RRYDR..KQsGYGGQTKPlF+KKAKT......TKKlVLRLEC..s..p..C..+p+pp.h.sl..KRCKHFELG.G..............	0	123	209	303
+4216	PF00281	Ribosomal_L5	L5;	Ribosomal protein L5	Finn RD	anon	Prosite	Domain	\N	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.57	0.72	-4.18	17	5354	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	5030	233	1428	3077	2087	56.40	51	30.97	CHANGED	Nh..MclP+..lpKlVlNhGlGEuspc...LppuhptLptIoGQKPlhT+A++olusF+lR	................................slMplP+..l-KIVlNMGVG...E.Ass..c.pKhL......-.sA..........s.p-.....Ls.......hIo.GQKPl......lTK.A+...KSlAuFKlR.................	0	489	916	1202
+4217	PF00673	Ribosomal_L5_C	L5_C;	ribosomal L5P family C-terminus	Bateman A	anon	Pfam-B_69 (release 2.1)	Domain	This region is found associated with Pfam:PF00281.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.12	0.72	-4.25	133	5473	2009-01-15 18:05:59	2003-04-07 12:59:11	16	5	5067	233	1480	3191	2159	95.30	53	52.03	CHANGED	sIGs.+VTLR.Gc+MacFL-.+llslslPRl+DF+GlsspuFDupG.NashGl..cEpllFPElc..Y...Dth.p..lhGMDlsll...............ToAcssp..........cu+.LLcthuhPFh	...........PIGsKVTLR.G-.RM.a.EFL-.+LlsluLPRl..R....DF.RGl........s........s........+u.F....D....G........R........G.N.YohGl..+EQl..I..F.PEI-.....YD+l-+..l..RGhDIslV.................................TTA...p...oD-..........EuRtLLpthuhPF.t...............................................	0	504	944	1249
+4218	PF01159	Ribosomal_L6e	L6e; 	Ribosomal protein L6e 	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	22.20	22.40	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.43	0.72	-3.81	46	607	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	377	8	327	549	4	102.90	43	45.55	CHANGED	lNGVPLRRVsQpYVIATST.KVDlusVc..........l.cc..lsD....sYFp+p+....pcp+......Ks.Es.shFs..pctp.cppsscpR+s.......D.....QKsVDssllsuIKKp.Pp...LppYLuupFoL+suphPHchpF	...........................................................lNuVPLRRlsQpYVIATST.KlDlSu..Vc..........l.c.+..lsD....tYFp+c+..........p+t+.........+p..Eu.-hFp.......pcpc...+h.....plsppRKt..........D..............QKsVDptllstIKt.h.P.......LpsYLtuhFuLps.G....hPHchhF.............................................	0	110	171	254
+4219	PF03868	Ribosomal_L6e_N		Ribosomal protein L6, N-terminal domain	Finn RD	anon	DOMO:DM07096;	Domain	\N	25.00	25.00	25.80	25.80	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.95	0.72	-4.08	19	310	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	167	1	127	268	0	59.80	38	24.76	CHANGED	hhspK...tpt+sSRNPsLsRGIGRYSRSAMYpR+uLYKhK...sKsstsh......KccsttsssKsl	..................ht...tK....tp.+ssRNssLs.+GIuRYSRStMYp++..A.lY+hK....hpsstst.......Kp+s.sslsKs...............................	0	38	57	81
+4220	PF01248	Ribosomal_L7Ae		Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	Bateman A, Finn RD	anon	Prosite	Domain	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	20.40	20.40	20.50	20.50	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.83	0.72	-4.47	54	5260	2012-10-10 14:40:03	2003-04-07 12:59:11	21	25	2077	176	2228	3938	199	91.70	23	56.33	CHANGED	pplpphlphuhcssp.lthGhpcssKslcps..cA+LlllApssss.phhp......hl.hlsp..cpslsh..hhls..uttcLGphsGhphh.ssuhulhssGsuphlh	...........................p..h.phlt.h.uh..cstp...lhhGhpp.......shK....s..lcps.............pup...........L..V.llA......p....Dss........s..........phht.........................l..shsp..........ctslP.h....h.h.lt.....s.p........t....cLGpssGpph......ssslulhs.t.t....h.................................	3	763	1239	1762
+4221	PF03948	Ribosomal_L9_C		Ribosomal protein L9, C-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.56	0.72	-3.90	147	4474	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	4407	129	996	2561	2059	87.20	34	56.38	CHANGED	hp....pA..pplAppLp..shs..lpltt+uG-.sG+LFGSVTspDIA-ulppp..GhclD++clpl.sp..s.IKslGpaplsl+LHs-Vsuplplp..Vssp	.........................................h.spApthtppLp....shp..VplssK.u......G..-....sG..+.L..F.G.....Slos+-IA-Alppt....G.......lc.......l-K+cl......cLsp...s.I+.slGpapVsV..+L.Hs.-VpuplpVpVst.................	0	346	671	852
+4222	PF01281	Ribosomal_L9_N	Ribosomal_L9; 	Ribosomal protein L9, N-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.04	0.72	-4.72	157	4600	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	4492	134	1130	2731	1908	48.00	47	29.79	CHANGED	McVILhccVpsLGctG-lVcVpsGYARNaLlPpshAhhATpts...lcph....c	................McVILlccVtsL..G.p..hG-lVpV+sGYARN.FLlPpGhAl.ATptslpthc....................	0	398	748	961
+4224	PF00338	Ribosomal_S10	S10;	Ribosomal protein S10p/S20e	Bateman A, Finn RD	anon	Prosite	Family	This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.	21.20	21.20	21.90	21.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.11	0.72	-4.14	193	5735	2009-01-15 18:05:59	2003-04-07 12:59:11	17	13	5081	211	1645	2828	1995	96.50	50	83.97	CHANGED	lRIcLcua-t..phL-pssppIlcsu......ccp.uhplpGPlsLPT+p.pphTlh+SPasp.Kco+-p.FEhRsHKRll-l................pssscsl..ctL.....h.plpl....PsGVsl-lpl	..................................................IRIRLKAaDH..+llDpostcIV-TA.................KRT..GAp....V.p...G.....P.I.P.LPT++..phaTll.+SPHhp..K.....cSREQ.FEhRTHKRLIDI.l.......................pP.T...s+TV....DuL......M...+L-L.....suGV-lEIp.......................................	0	550	1016	1368
+4225	PF00411	Ribosomal_S11	S11;	Ribosomal protein S11	Finn RD	anon	Prosite	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.13	0.72	-3.88	13	6124	2012-10-02 16:33:16	2003-04-07 12:59:11	14	12	5534	199	1594	3230	2256	109.70	55	79.77	CHANGED	GlsHIpuSF....NNTIlTlTDlpGpslsWuSAGusGFKuoR.KuTPaAAptAApsAActsh-pGhpplEVpl+G........PGsG+-uAlRAlp+uGlhIspIcDVTPhPHN.GCRPPK+RR	.....................................................GlAHIpuoF....NNTIVT.I.T...Dh.p.......G........N.........s........l.u..W.....u.....SA...G.u.h.G.F...K.GSR.....K.STP.FA.AQ..hA.A...E...s.Auc..t..A.........h....E.......h.......G....l....+..s...l-...V...h..V.K.G..............................PGsGRE....o.A..l....RA.L.....p....u.....u...G.....l....c........l....o....tIpDV.TPlPH...N.GCRPPK+RR......................................	0	517	960	1328
+4226	PF00164	Ribosom_S12_S23	S12; Ribosomal_S12;	Ribosomal protein S12/S23	Sonnhammer ELL	anon	Prosite	Family	This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.	19.90	19.90	20.00	20.00	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.68	0.71	-4.69	18	6678	2012-10-03 20:18:03	2003-04-07 12:59:11	20	19	5947	204	1582	3422	2092	119.60	62	94.59	CHANGED	sThppLlR+c...........RcchtpcsKssALcGsPp++GlChclhslpPKKPNSAlRKlsRV+Lp..NGhcVTAaIPG-G..HsLpEHs.VLlcGGp......VtDLPGVRY+ll+GhhDsuGVp..tRtpuhSKYGsc+P+	.....................................TlpQ.Ll.R.+.s..............R.p...p.h.h.p+.s..+....sP.A.............L..............p...............u.............s.PQ+.RGV...CTRVh..............ThTPKKPNSALRKVARV..RL......o........NG......hEV.TAYIPG.G...HNLQEHSVVLlRGGR.......VKDL..PGVRYH..IVRG.sLDsuGVp........sRpQuRS...KYGsK+PK......................................	1	531	988	1316
+4227	PF00416	Ribosomal_S13	S13;	Ribosomal protein S13/S18	Finn RD	anon	Prosite	Family	This family includes ribosomal protein S13 from prokaryotes and S18 from eukaryotes.	24.60	24.60	24.70	24.70	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.39	0.72	-3.59	15	5791	2012-10-02 21:21:44	2003-04-07 12:59:11	17	7	5215	199	1480	3234	2174	105.00	49	84.93	CHANGED	RlhssslsusK+..lhhALTtIaGIG++pAptlhpcsslDtspRsu-Lo--plcpltphlsp.......................ahlpu-LcpclppDIcRLhcIcsYRGlRHhtGLsVRGQRTKTNuRT	.......................................RIAGVslPpc...K+..l.IuL.T.a.IaGIGpspup....pIltps.G.............ls.....s....h+lp.-Lo-...-plsplRc..ls.p.........................................................................ahVEGDLRREls.hsIKRLh-lG..s....YRGlRHR+G.LPVRGQ+TKTNART..........................................................................	0	503	954	1256
+4228	PF00253	Ribosomal_S14	S14;	Ribosomal protein S14p/S29e	Finn RD	anon	Prosite	Family	This family includes both ribosomal S14 from prokaryotes and S29 from eukaryotes.	19.70	19.70	19.80	20.50	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.84	0.72	-4.58	178	6805	2009-01-15 18:05:59	2003-04-07 12:59:11	16	10	5516	200	1562	3442	1882	54.30	45	63.36	CHANGED	hp..lpph.cspshsRhpsRChlsGRs+..uhhR+F.sl..sRhsFR-hAtpG.lPGlpKuS	................t..lpphP+s.usssRhpsRC............phsGRP+..uhh..RKF.GL..sRlphREhAhcGplPGlpKuS....................	0	508	968	1302
+4229	PF00312	Ribosomal_S15	S15; 	Ribosomal protein S15	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.90	20.90	21.10	21.90	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.55	0.72	-4.22	9	5932	2009-01-15 18:05:59	2003-04-07 12:59:11	17	14	5410	212	1580	3366	2136	82.00	44	77.02	CHANGED	htpthhlpphtcpppspGSsEhQlhhLTp+l.+LppHhccH+KDapSpRGLhphluKR++LLsYL+pcs.....hh+YcphIppLGlR	...................................c..Ksplltca..t..p..p..c..s..DT.GSsEVQlAlLTt+IspLs.cHhc..p.H....K..K.D+cS+RGLl+hVu+RR+LLsYL++pD......htRYcp...LIpcLGLR....................	0	536	990	1322
+4230	PF00886	Ribosomal_S16		Ribosomal protein S16	Bateman A	anon	Pfam-B_1025 (release 3.0)	Family	\N	21.20	21.20	21.40	21.60	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.89	0.72	-4.25	158	5911	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	5742	192	1200	2936	2304	56.10	47	58.89	CHANGED	RhGpK+pPaY+IVVsDuRssRD.G+aIEplGhYsPh....tp........................................plplch-+hphWlspGAQPo	..........RhGtK+p..P...FY+lVVsD.uR...s.....R..D.GR..hIEplGhY.....N..Plts..............................................plplch-+.lhaWLspGAQPo..............................	0	415	780	1019
+4231	PF00366	Ribosomal_S17	S17; 	Ribosomal protein S17	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.33	0.72	-3.93	15	5324	2012-10-03 20:18:03	2003-04-07 12:59:11	15	10	4890	201	1529	2971	1891	68.80	50	69.69	CHANGED	GhVVSsKMcKTllVcl-phthHPKYs+hlKRpKKh.AHsssshppl..GDlVcItEsRPLSKTKRFpVlcV	.............................GpVV.S.D.K..M-KTIsVtlE.p..........hh.p.HPlY.u.........K.......hl++opKh....+AHD.Es..N.p.s..p.l....GDhVcI..h.E.s.RPLSKTKpapLVc........................	0	521	966	1279
+4232	PF00833	Ribosomal_S17e	Ribosomal_S17; 	Ribosomal S17	Bateman A	anon	Pfam-B_1566 (release 2.1)	Family	\N	22.80	22.80	23.30	24.70	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.63	0.71	-4.36	32	683	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	508	9	396	637	67	107.30	53	84.61	CHANGED	MGRVRTKTVKRAuRhllEKYYs+LT.hDFppNK+ls-E..VAlIsSK+LRNKIA...GasTHLMKRIp+GPVR....GISlKLQEEERERR.saVPEhStlDhs......hlpVDt-Tp-ML+p.hsh..slsshhl.st	.........MGRVRTKTVK+uu+hlIE.+YYs+LT.hDFcTNK+ls-E...lAlI.s.SK+LRNKIA...G.YlTHLM.KRI....Q+G.PV.R....GIShKLQ.EE.ERER+.paVP-hSAl.-.p........lcVD.-Tt-hLc..Lsh..pls......s................................................................	1	138	226	324
+4233	PF01084	Ribosomal_S18	S18;	Ribosomal protein S18	Finn RD, Bateman A	anon	Pfam-B_712 (release 3.0)	Family	\N	21.00	21.00	21.20	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.46	0.72	-4.10	121	5681	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	5182	193	1326	2673	1849	53.20	50	56.97	CHANGED	tpphp.hlD....Y.KcschLp+Flo-.pGKIlPRRlT..GssuKpQRplspAIK+ARhlALL	......................s..thppID.........Y.KDs.shL+c.FIoE.pGK..IlPRRlT..GssuKtQRplspAIKRARhluLL............	0	451	833	1106
+4234	PF00203	Ribosomal_S19	S19;	Ribosomal protein S19	Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.69	0.72	-4.36	22	7420	2009-01-15 18:05:59	2003-04-07 12:59:11	16	5	6888	210	1487	3278	2069	78.30	55	82.39	CHANGED	Rol+KsPFssh+Lh+Khcp.s.ttcK.phl+TWSRsSsIlPpMlGpslulYNGKpal.VhIoscMlGHKLGEFu.TRphttH	..........................................................RSLKKuP.F.V.s.t.H.L.h....+K...............l...-.t.h....s........t...p...........t.c.K...cs......I+TW...S...RpST.IhP.shlGhTIA.VHNG..+cHl.PValT.-.c.MV.G.HKLGEFAPTRTapGH.............	1	498	945	1255
+4235	PF01090	Ribosomal_S19e	S19e; 	Ribosomal protein S19e	Finn RD, Bateman A	anon	Prosite	Family	\N	24.20	24.20	24.50	25.30	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.46	0.71	-4.75	62	756	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	526	9	441	663	97	128.00	43	85.22	CHANGED	sTVcDVsscchlptlAphLKcs.s+lcsP-WsshVKTGsaKEhsPps.sD.WaYhRsASlhR+lYlcu.PlGVtpl+phYGG++c..+G..s+Ps+as+uSGulhRpsLQpLEphGlVcKs......psGRplTspGpp.LD+lAtplhpcht	..............................oV+DVstpchlpshAtaLK+p...GKlcl..........PpWsDhVKTu.ttKEhsP.-...D.WaYhRs...ASlhR+lYlRs.........slGVG..php+lYGGppp....pG..spPsHascu.SGulhR+sL.QtLEphtllEps.........pu....GR.plTtpGp+DLD+IAsplhtt.p......................	0	182	268	368
+4236	PF00318	Ribosomal_S2	S2;	Ribosomal protein S2	Finn RD	anon	Prosite	Family	\N	23.80	23.80	24.00	23.90	22.30	23.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.26	0.70	-5.11	177	7370	2009-01-15 18:05:59	2003-04-07 12:59:11	15	20	5811	224	2025	5251	3040	185.10	40	79.94	CHANGED	lLcAGlHh.GH.p......sphWNP+Mp...Y.Iasp.R..s...GlHIIDLpc.ThthlppAhchlpphst.ps....................................................................sc....lLFVGTKp...pu..pchltctApcs......sth.al.s.....pRW.lGGhLTNapolppplpphc......h................t.hsK+p.h.htcpht+Ltp.hsGlpphtpl..Pc....l...lhllDs....pp-p.AlpEApcLsIPll..ullDTNssPsh...lDasIPuNDDuh+ulpLhhphluculhcup	.....................................................................hLcAGVHF.GH.p......T..+pWN.PKMt...a..Iasp....R...s.........................u.l.a.IIsLp+.Tht.hhp.pAhphl....pphst..ps....................................................................splLFVG.TK+........pA..............p-slt....c...tA.tcs.............s.th...aV..N.........pR.W.LGGhLTNapTl..ppplp.+hc.c....lct.tpsG.............................hphhsKKEhh...h.p+pht+.L.pp.....LG.GIcp.........Mttl..........Pc................h.lhllDs.....pc.E....p..hAlpEA....ppLsI....Pll..ul.l.DT.N.sc.P-.................lDhsIPu..ND.DAh+ulpLhhthhApAlh-u......................................................	0	683	1211	1641
+4237	PF01649	Ribosomal_S20p		Ribosomal protein S20	Bateman A	anon	Pfam-B_1685 (release 4.1)	Family	Bacterial ribosomal protein S20 interacts with 16S rRNA [1].	20.60	20.60	21.40	21.40	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.93	0.72	-3.60	14	4402	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	4355	191	972	2284	1917	80.90	41	93.95	CHANGED	ANhKSApKRh+psp+pRl+NpuhKStl+ThlK+shpslpss-ps.......tAppths.stphlD+supKGllHKNpAAR+KS+LAttlpp	...........ANhKSAhK.Rscpsp+ppt+Ntuh+SthRThlK+s.c....tAlts.s.D.p.p...................sAp..pthptApphlD+sA..s.KGlIHKNpAAR+KSRLutplp.t...................	1	342	654	833
+4238	PF01165	Ribosomal_S21	S21; 	Ribosomal protein S21	Finn RD, Bateman A	anon	Prosite	Family	\N	21.00	21.00	21.70	21.30	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.66	0.72	-4.52	140	4324	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	3974	61	1053	1753	1966	57.00	45	77.38	CHANGED	s.pVplpcs-.sl-pALRRFK+php+sGlhp-h+cRc...aaEKPotcR++Kpttut++p.t+	............s..lhV+-NE.shDsALRRF...KRs.spKsG.........llpEhR+.R.E...aYEKPoscRK.++ptuAhKRch+.............	0	333	644	864
+4239	PF01249	Ribosomal_S21e		Ribosomal protein S21e 	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.40	25.10	18.30	19.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.94	0.72	-4.04	36	472	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	349	6	258	420	6	79.10	54	76.04	CHANGED	MpNDsGchVDLYlPRKCSATNRlIsAKDHASVQINlucVDts.G+.hsGphpTaA...lsGhlRphGESDcslsRLspccGllsps	..................MpN-tGch.VDL..YlPRK......C.S.AoNRIIpAKDHASVQIslucV.Dcs..GR.hs.GphpTYA...lsGhlR......th....GESDD.ulsRLApc-Gllt..s......................	0	88	142	211
+4240	PF01282	Ribosomal_S24e		Ribosomal protein S24e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.30	25.00	24.30	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.61	0.72	-4.19	70	778	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	520	12	448	664	66	83.90	46	63.63	CHANGED	hhl-lhHsup.uosS+p-l+-KLAphhps.ss-tlhlash+TpFGsG+osGauhIYDsh-thKchEPcatLhRs.slhpc.ct..tucc	..............................hVlDVLHPG+.AoVsK........sElREKLAchY.Ks.ss-sl.hVFGFRTpFGGGKoT..GFuhIYDol-hAKKhEPKa..RLsRp..GLhcKhc..uR.p.......................................	0	129	224	315
+4241	PF03297	Ribosomal_S25		S25 ribosomal protein	Mifsud W	anon	Pfam-B_4038 (release 6.5)	Family	\N	28.80	28.80	28.80	29.10	28.70	28.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.42	0.72	-4.00	24	591	2012-10-04 14:01:12	2003-04-07 12:59:11	10	9	405	8	328	514	4	102.30	49	83.60	CHANGED	MPPKc........p..pttKtttusuGGKs.+KKKWSKGKs+DKLsNhVlFD.KuTYDKLhKEVPsYKlITsSVlS-RLKIsGSLARpALc-Lpp+GlIK.V.s+HpuQhIYTRus	.....................................t......t.t.pt..s.s...t.uGGKt..cKK.KWSKGK..V.+DK...lNNhV.L.F.D..csTYDKLhKEVPs..Y.KLIT...PuVlS-RLKIpGSLARtALp-Ltp+GlIKhV.spHpsQhIYTRs.................	0	112	176	252
+4242	PF01283	Ribosomal_S26e		Ribosomal protein S26e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	20.70	21.00	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.46	0.71	-3.85	37	581	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	425	4	325	528	16	107.20	56	86.00	CHANGED	MspKRRNsGRsK..+uRGHVp.lRCoNCuRsVPKDKAIKRFslRNlVEsAuhRDlp-Au.lY...psYslPKLYhKhpYCVSCAIHu+lVRlRSc-.....sR+.Rsss.+h....t.ttp.sst.s	...............MspKR+NsGRsK..+G.RGHVpslRCoNCuRClPK..DKAIK+FslRNIVEu..AA........lRDlsEAS.Va...............stYsLPKLYsKLpYCVS.CAIHu+lVRsRS+E.....sR+sRsPP.Rht.t.........ss..............................	0	118	180	260
+4243	PF01599	Ribosomal_S27		Ribosomal protein S27a	Bashton M, Bateman A	anon	Pfam-B_638 (release 4.1)	Domain	This family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins as extensions of ubiquitin promotes their incorporation into nascent ribosomes by a transient metabolic stabilisation and is required for efficient ribosome biogenesis [3].  The ribosomal extension protein S27a contains a basic region that is proposed to form a zinc finger; its fusion gene is proposed as a mechanism to maintain a fixed ratio between ubiquitin necessary for degrading proteins and ribosomes a source of proteins [2].	21.30	21.30	22.50	22.50	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.58	0.72	-4.14	12	740	2012-10-03 10:42:43	2003-04-07 12:59:11	14	11	555	5	375	629	45	45.60	58	31.50	CHANGED	AVLcYYKVDssGKlpRLR+ECPt.pCGuGVFMApHtDRpYCGKCthT	..................AVL+aYKV...D.c.s..G..K.l.....pR.LR+EC...Ps...cCGA.GV.FMAsH...h...D...RpYCGKCshT........	0	122	208	302
+4244	PF01667	Ribosomal_S27e		Ribosomal protein S27	Bateman A	anon	Pfam-B_1929 (release 4.1)	Family	\N	24.50	24.50	24.50	25.30	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-8.76	0.72	-4.42	7	748	2012-10-03 10:42:43	2003-04-07 12:59:11	12	5	546	9	399	669	46	54.30	62	63.75	CHANGED	PpShFlcVKCPsChs.psVFuHupThVhChtCupsLspPTGGKu+lptth..hhc	..............................PsSaFMDVKCPGCapITTV.FSHAQTVVlCsuCuTVLCQPTG.GKA+L.TEGCSFR+K..........	0	125	218	314
+4245	PF01200	Ribosomal_S28e		Ribosomal protein S28e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.70	25.70	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.15	0.72	-4.23	38	607	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	501	10	344	470	76	67.10	58	88.74	CHANGED	M-pt......ptsh.....AcV...lcllGRTGscGplTQV+V+lLcs.sp....sRhlhRNVKGPVRhG..DI.LhL...hETEREA.R+Lc	.........................p.sphAcV...h+V..LGRTGSpGpsTQVRVcFl--..ss.....RpIlRNVKGPVREG..DI.LsL...LEoEREA.RRLR......	0	109	191	285
+4246	PF04758	Ribosomal_S30		Ribosomal protein S30	Wood V, Bateman A	anon	Wood V	Family	\N	20.00	20.00	21.00	20.70	18.70	17.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.83	0.72	-4.22	23	515	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	387	7	297	462	15	57.30	61	58.05	CHANGED	KVHGSLARAGKV+sQTPKVsKpEK+.Kp.sGRA+KRhpYNRR....Flsll.t.G...+K+GsNups	.....KVHGSLARAGKV+.uQTP..KV....-KQ....E..KK....Kp.pGRA++RhpYsRR....FVNVs...s.hG....pK+t.Nss.......................................	0	113	168	244
+4247	PF00189	Ribosomal_S3_C	S3_C;	Ribosomal protein S3, C-terminal domain	Sonnhammer ELL	anon	Prosite	Domain	This family contains a central domain Pfam:PF00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain.\	  Some are much longer.	21.30	21.30	22.30	21.80	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.64	0.72	-3.77	124	7624	2009-01-15 18:05:59	2003-04-07 12:59:11	15	11	7097	199	1388	4926	2193	82.90	50	31.68	CHANGED	pl..........uppLEc+........h.sFR...+sh+psl......pph......psu.s.cGl+lplSGRL...sG....s-hARsEh..hpc........Gpl..sLpolcspIDYuhspAtTphGhlGlKVWI	...................................................IAtQL.cpR..l.uFR...RA..hKpAl.........pps................hpusA..+GIKl.plSGRL....sG.......AEIA.RoEh..a+E.................G+l.........PLpTlRAcIDYuhtEAcTp........YGhlGVKVWI.....................	0	478	888	1168
+4249	PF01015	Ribosomal_S3Ae		Ribosomal S3Ae family	Bateman A	anon	Pfam-B_1334 (release 3.0)	Family	\N	25.00	25.00	27.20	27.10	22.10	18.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.05	0.71	-4.98	69	888	2009-09-11 07:57:53	2003-04-07 12:59:11	13	8	583	4	470	815	113	191.30	50	82.23	CHANGED	ut+Kst.t+hhDsap.pKcWYslhAPsh.F....sppplGcThssc.......s-tlhGRlhEsoLuD.LssD.p..psapKl+hplpcV.pGc..sshTpFhGh-hTcDhlRSLVR+hpohI-uhl-V+TpDGYh.lRlhsluaTp++............ApsSQh+sIRcphh-llpccusptshcphVpcll...............sslup-I.c.ps+pIYPL+cVtIRKlKlLcpPc	..........................................................tuKKGh.KKKssDPFs.+K-WY-l..KAPsh.F....s.hRs...lGKTLVs+opG.....................h+.As-uLKGR.....VhEVSLAD.Lps...D.-....puaRKh+Lhs-.-V..QG+..Ns.LTNFaGh-hTpDKlpShV.+KWp.T.hIEApV-VKT..oD.uYh.L.RlFsluF.....T+++.sQh...++TsYAppoQlR.tIR+KMhEI.hpccs................psssL..cclV..pK.l.I..............P-s...Iu+-IEK.uspsIYPLp.sValR.KVKlLKpP+..........................................	0	157	256	356
+4250	PF00163	Ribosomal_S4	S4;	Ribosomal protein S4/S9 N-terminal domain	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family includes small ribosomal subunit S9 from prokaryotes and S16 from metazoans.  This domain is predicted to bind to ribosomal RNA [1].  This domain is composed of four helices in the known structure.  However the domain is discontinuous in sequence and the alignment for this family contains only the first three helices.	21.70	21.70	21.70	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.14	0.72	-3.61	18	11914	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	10020	203	1485	8634	2034	83.20	44	43.67	CHANGED	uR.YpGsphKhsRR.sphstLssc....ppptsp......pstpcshps+h........+hSpYtlpLcEKQKlRhhYG.lhERQLhpYsclu...pKh+GspG.slhplLE	...................................................................................h+h.RRhG..h....h..Lss.+.............t..t.h.c.s...............ss.tppu..tspp..............K.lSpYtl.p...L..c.E.KQK.LR.a.pY.......G..loERQhhpYh+hA...........p+tK.G..s...T..GpsLLQLLE.........................................	0	530	969	1271
+4251	PF00900	Ribosomal_S4e		Ribosomal family S4e	Bateman A, Finn RD	anon	Pfam-B_1205 (release 3.0)	Family	\N	25.00	25.00	25.00	25.50	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.35	0.72	-4.31	81	821	2009-01-15 18:05:59	2003-04-07 12:59:11	15	13	555	7	448	754	91	75.80	52	30.43	CHANGED	cosEpaRllhDs+GRhslpcIss-EAphKLs+lpsKshspsGhsplshHDGRslhhsp.........sph+ssDolhlsl...ssp......cIh	.....KTsEpFRLlYDsKGRFslH+Ios..EEAc...YKLCKV+.+lph.......Gp+GlPa.LsTHDGRTIRYPD.........PhIKsNDTlplDL.tosKIh.....................	0	144	246	342
+4252	PF00333	Ribosomal_S5	S5; 	Ribosomal protein S5, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	27.00	27.00	27.00	27.20	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.04	0.72	-4.23	13	5805	2012-10-02 17:51:51	2003-04-07 12:59:11	15	11	5179	202	1620	3309	2088	66.50	52	34.20	CHANGED	cLpE+VlslpRVsKhs+uGR+hpFpAlVVVGDcNGpVGhGhGKA+E.VssAIpKAltpAK+sllsVsh	.....................pLpE+llsINRV.sKs.V.KG.GR+hpFs..ALVVVG..D.t.s.G+.VGhG.hG.KA..+.E..VPsAIpK.Ah-pA++..shlpVs.h....................................	0	552	995	1332
+4253	PF03719	Ribosomal_S5_C		Ribosomal protein S5, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.40	20.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.26	0.72	-4.70	114	5623	2012-10-03 01:04:38	2003-04-07 12:59:11	10	12	4962	202	1648	3246	2178	73.10	45	37.14	CHANGED	VhG+aGuu+Vhl+PAstGTGlIAGG.ssRuVlEhAGlcD....lhsKohG.SpNshNhl+AThcuLpphposcplAphR.G	................lpGcaGuucVhlpPAscGT.....GlIA.GG.ssRAV.LEhA.GlcD.....lluKo.h.....G...Ss..NP..hN.lV+AT.lcu.L.p.p.hpss.cplAthRG....................	0	557	1007	1357
+4254	PF01250	Ribosomal_S6		Ribosomal protein S6	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.10	21.00	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.76	0.72	-4.14	180	4748	2009-09-12 05:02:19	2003-04-07 12:59:11	12	8	4630	210	1190	2634	2089	91.70	35	77.12	CHANGED	+pYEhhaIlcPcls-c.phpshl-chpsllppp.uGplh.ch-p...W.Gc.R+LA.Y.IpKh..........pcGaYhlh.phpu..s.spslpEl-Rth+ls-sllRahsl+h	......................p+YElhal...l...+...P.s..hsEp...phs......uhlE+a.psllsss.GGplp.ch-c...W.G+....RpLA....Y...Ip....K.h.....................................+cGaY.....hll.slcu..s...spsls.El-+.....hh+.....l.....s.-sllRphll+.h...................................	0	409	769	1011
+4255	PF01092	Ribosomal_S6e	S6e; 	Ribosomal protein S6e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.20	25.20	24.10	24.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.45	0.71	-4.50	7	798	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	566	5	447	741	92	116.50	52	53.22	CHANGED	MKLNlSaPtsGsQKhlElDD-+plRhFh-KRhGpEV-u-hlG.EacGYsl+IsGGNDKQGFPM+QGVLsssRVRLLhucGpsCYRPRRsGERKRKSVRGsIVsssluVLsLsIl++GEp-IPGLTss	.................................hKlNlu.PssGsQKhlEl.-D-p.+lR..Fh.-KRhupEVsu........-........s..L........G........-........E.a.........K............G.........Yl.h+IoGGsDKQGFPMKQ.GVLsssRVRLLLs+G............ps.CY..R...P...R..R...............sGERK.R.KSVRGCIV........sssLuVLsLlI.V.K.pG...Ep.....-lsGLTD.........................................	0	141	238	341
+4256	PF00177	Ribosomal_S7	S7; 	Ribosomal protein S7p/S5e	Sonnhammer ELL	anon	Prosite	Domain	This family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.77	0.71	-4.62	166	7992	2009-01-15 18:05:59	2003-04-07 12:59:11	16	14	7200	206	1618	4678	2374	146.70	44	86.24	CHANGED	MsR...+.tpst+R...l.s....Dshasst.........lVs+hlNplMh....................cGKKulApcIlYpAh-hl............pp....+.spp...sP.................lp.....lhppAlcNlpPtlEV+.......uR......RlGGuoYQV.PlEV.ps.pRphsLAlRWllpuuR....p.......Rs.t+..sMsp+LAsEllDAu.ps..pGsAlKK+E-sH+M...AEA.N+	.....................................................sR+..sphs++...h...s....Dshapst.........lVs+.llNplMh....................cG....KKuhA.pI...VYpAh-hI......................................cp.....+...Tuc.........sP..........................................................Lp.....VhppAlpNltPt.l-V+........uR......R...lG.Gu.sa.Q.V.PV.EV..pP.tRRssLAlRWLlsuAR............h...........Rs....tK.....oMs-+LAsELlDAA..ps...pG..........sA.lK.K+E-sH+M...AEAN+..........................................................	2	573	1027	1367
+4257	PF01251	Ribosomal_S7e		Ribosomal protein S7e	Finn RD, Bateman A	anon	Prosite	Family	\N	26.60	26.60	26.60	26.90	26.10	26.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.14	0.71	-4.82	27	599	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	415	4	298	532	6	174.90	53	92.14	CHANGED	sKIhKpsst....PoEhEpsVAQALhDLEsss...-LKupL+sLplsuA+E.l-luu.sKKAlllaVPhP.Lpua.+KIQt+LsRELEKKFus+cVlhlApRRILs+PpRp..tt...ppQKRPRSRTLTAVH-uILEDLVaPuEIVGKRlRh+lDGo+lhKVaLDp+-pss..lEaKl-oFsuVY+KLTGK-VsFEFP.stt	............................................Kl.Ksp..stp...PsEhEps.luQ..........ALh....-LE.ss...DLKu.pLR.c.LtIsuA+E...l-Vus.....s+..............KAll.IaVPhP.L.+uF.pKI..QsRLlRELEKKFS.G+.HVlhlAp.RRI.LPK.PpRp..s+....ppQKRP.R.S.RTLTAVHDAILEDLVaPsEI..V..GKRlRh.....+lDGS+llK.....Va.L.Dp.pppss..lEa.Kl-TFuuVY+KLTG+-VsFEFPt...................	0	102	164	239
+4258	PF00410	Ribosomal_S8	S8; 	Ribosomal protein S8	Finn RD	anon	Prosite	Domain	\N	24.00	24.00	24.50	24.50	21.10	23.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.51	0.71	-4.30	119	6129	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	5619	211	1551	3553	2221	126.70	42	95.88	CHANGED	DsIuDhLTRIRNAphsp+ppVpl.Ps........................SKlptslhplLpcEGYIpsaph.........hppppp...t...............................lplp.LKY.........pttps..lIpplpRlS+PGhRlYsstpclP+.......lh..sGhGl...........sIlSTS+G.lMoc+cARcppl.GGElLChVa	....................................................DPIADhLTR..IRNA.pts.p....+psVpl..Pu........................SKlK..tsIs.plLpc.EG...........aIcsach...........................hc..-..s.p..t......t.......................................................................lplp.LK.Y.............ptct..........lI.p...s...l..cRlS+PGLR..lY.sptc-.lP+.........Vh......sG..L...GI............................uIl.....ST..Sc....G......l...hTD+cA.Rp...............psl..G.GEllsYVa..........................................	0	516	966	1289
+4259	PF00380	Ribosomal_S9	S9;	Ribosomal protein S9/S16	Finn RD	anon	Prosite	Family	This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.	21.80	21.80	21.90	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.56	0.71	-3.86	183	5483	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	4963	199	1599	3183	2185	121.50	50	81.31	CHANGED	GRRKoulARVhl.ps.G.....................s....G.p.lplN.s+............sh...p-Ya..spphhphplhpPLt.lssp...........................................................hsp...............................aDlhlp.................VpGGGhoGQAsAlRhuIARALlp.....................................hs....sp............h+stLKpt......GhLTRDsRhhERKKa..Gh++AR+p.QaSKR	...............................................GRRKsulARVhl...hP...G.................................................s.....G...cI..slN.s.+.....................s.lcpYa..s....pc........sh.chhl.pQPL.t.l.s.pp...........................................................h..s..p................................aDlhls.................V.p.G..GGhoGQAG.....A.IRHGIuRAL.hp.............................................hD...ss..............hR.ssLKcA..............................................GhLTR..DuRhsERKKh..GL..+KAR+tsQFSKR......................	0	557	1015	1351
+4260	PF00834	Ribul_P_3_epim		Ribulose-phosphate 3 epimerase family	Bateman A	anon	Pfam-B_1291 (release 2.1)	Domain	This enzyme catalyses the conversion of D-ribulose 5-phosphate into D-xylulose 5-phosphate.	20.60	20.60	20.60	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.32	0.71	-5.21	13	6022	2012-10-03 05:58:16	2003-04-07 12:59:11	14	17	4642	50	1359	4019	3152	198.40	43	88.92	CHANGED	hlAPSILSADFu+LucElpslppuGuDhlHlDVMDuHFVPNlTlGPhVlculRsh...sphPlDVHLMlcssDphlssFAcAGAs.hIoFHsE..AocHlcRolphI+ctGsKAGlVLNPuTPLssl-alL-clDlVLlMSVNPGFGGQuFIPssLsKlcpl...R+hhsp......hshhlEVDGGlsscshtplscAGAshlVAGSAlFuus	.....................................................................................................................................IAPSILSAD..F...ucLu.c-l.ppl...p......t...u.....G...A.DhlHlDVM...D........G..........HFVPN...l.T..h..Gs..llcu..l.Rph...................sphP.....l.DVH.L.Ml....p......s..............P..-.......c.......a.lss.F...Ac.A......G..A.s....hI......oh.H.sE..................A.s......p....H......l...c.......R......s.l...p...h...I.+........p......t.....G....h.K...................A.........Gl.s........l.N.P.u.T..P.l.p.h...l.c....l..l......c........p......l.......D.h..lLl...M.o.......V.N....P..G.F....G...G....Q...p...F...Isp.s.l...cK.l.cpl......+..phhc.pps..................hs.hpIEVDGGl.s..s.p.s.h.tphs.p..AG.A-.hhVA.G.S.u.lFpt.s.....................................	0	465	866	1148
+4261	PF02009	Rifin_STEVOR		Rifin/stevor family	Bateman A, Lawson D	anon	Lawson D	Family	Several multicopy gene families have been described in Plasmodium falciparum, including the stevor family of subtelomeric open reading frames and the rif interspersed repetitive elements. Both families contain three predicted transmembrane segments. It has been proposed that stevor and rif are members of a larger superfamily that code for variant surface antigens [1].	34.70	34.70	35.40	54.50	33.20	34.60	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.28	0.70	-4.77	16	412	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	2	0	71	414	0	288.50	30	96.01	CHANGED	aNp..Np.hITs..ppsshoo......RhLsEC-las.spYDNDPEMKcVh-pFscpToQRF+EY-ERhhspRpKCK-psDK-IQcIIlKDKhE.........................KSlA-KVEKsCL+CGssLG.GlhsusGlhG...slulsph.sp....uAthsAhp.h.csu.................htsslcph.......cuhsphhshhsh...............thhpulhssssYps.hsllsslhs.tstshCshspsstsshhshsspsttshhstp....................VpshspsAsssAptsspthstsltptssuhhss........IhuSllAIllIlLlMlIIYLILRYRRKKKMpKKhpYhKLLpc	.....................p........h...ps......R.LsEC-las.s.Y-sDsEMKpVh-pFs.cpT.pp.RF....cEYcE.+h.cpRpppKEps-KpIQ..KIIhKDKhE...........................KSls-KsEKt.CLcCuhshG.ulssphGlhu...........shshsth.ps........sshss....u..hp.u...ttu.....................htssltts..........c.shsphhthhph....................tshpslhsss.....sasshhslh......shlts...th.........t.s.h...s..........s..h.........s........s....s.....s.......t..............h...shsh...thhph..hst.......................................stphhps..usssutt....ss..s.th.s....s....shtstthu...hhps.......tsIhuSslslllIll.lhlIIYLILR.YRR.+K.phKhp..KhL.......................................	0	71	71	71
+4262	PF02197	RIIa		Regulatory subunit of type II PKA R-subunit	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.42	0.72	-4.52	13	656	2012-10-01 20:11:07	2003-04-07 12:59:11	12	27	223	33	372	614	5	37.00	33	10.58	CHANGED	pulpsLLcshsspVh+ppPuDllpFstsYF.p+LpcpRt	...........slpplLcshthpllpppPs....clh...pFsspYF..p+Lpptp..........	0	132	172	259
+4263	PF01782	RimM		RimM N-terminal domain	Bateman A	anon	PSI-BLAST P51419	Domain	The RimM protein is essential for efficient processing of 16S rRNA [1]. The RimM protein was shown to have affinity for free ribosomal 30S subunits but not for 30S subunits in the 70S ribosomes [1].  This N-terminal domain is found associated with a PRC-barrel domain [2]. 	23.50	23.50	23.50	23.90	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.74	0.72	-4.06	170	4228	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	4195	7	921	2739	1298	83.60	27	46.27	CHANGED	hlGpIsssaGl+Gpl+lhsh.T-....s-thhshtshhht..................pttt............hplpph+.hp..pp.thllphcGlss+spA.ctLpGtpl..hlscsp	..............lG+lsssaGl+Gcl.+Vhs.h.TD......s-..p.hhc.h..ss..hhht.......................................pssp.........h.t..........lplps..h+..hp..........ps.hhll+hcG.....ls.....stssA.ctLpstplhlspp................................	0	302	605	781
+4264	PF00848	Ring_hydroxyl_A		Ring hydroxylating alpha subunit (catalytic domain)	Bateman A	anon	Pfam-B_407 (release 3.0)	Domain	This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems.  The active site contains a non-heme ferrous ion coordinated by three ligands.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.46	0.70	-4.68	128	4563	2012-10-02 19:24:03	2003-04-07 12:59:11	14	18	1613	110	962	3945	3034	206.60	16	58.44	CHANGED	hp.ph.phttphphc....................hpsNWKlhh...-NahE.sYH..hs.ssHsph.t...hppht............................................t.t.h.h..............h.hshttt.tttsth......th.pptphtsh....................hhhlFPNhhlt.hhsshhh...hhphhP...husspsphphphhhtss............tssch..............tpphtphhpt............ltpEDhthscphQpG....lpo.....................sh..tsu..h.........sttEt.sl..pp....Fpphltchl...st	...................................................................................ht.hhp.......................htsNWKhhs..Es.h.h-...sYH...ss.hsH....shs.p.s.h..tths....................................................................t...hth..s.tts.hh..............................h...t.sh.s.h.p.hhtt....hsttp.h.......................t.ht..tt.....h..thh....................................................................th.s.la....Psh.hh....................ss..thh.............hphh.hP.......hussc...sp..h...hhhh.hs.t.s.....................tstch.....................ppthhp.h..t........................ht.pDht.htt....pts.......hts.....................................................................................-.............h......t..................................................................................................................	1	181	516	777
+4265	PF00161	RIP		Ribosome inactivating protein	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.70	20.70	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.47	0.70	-5.14	73	945	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	239	176	103	936	0	197.20	29	61.64	CHANGED	sFslssus...psYssFlpsLRsplsssstt.......hs..lPlL.......ssssp+alhlcLps....ssp.....lTLulchsNlYVlGY......psssphahFp............psspssLhsss.....tpppL.sasGsYssLpptush......Rpp.lsLGhptLssulssLhths...................................sspstAcsLllhIQMluEAARF+aIcppltssh........tpshpPs...sthlsLcssWuplSptlppu	...................................................................................Fsht.ss...tsYss.lsslRppl..tp.hpp........hpt..hsVhs.p.......tssstpahhl-lpsh..........ptp....p.lpLhlchsNLYlsGFh........sssssaapFs................................-hsphhhsss...........pshsl.shsu.s.YssLppsuu............Rps.hpluc.tsLssuh.s.Lhpassss.................................ppstu+......ullt.hlphsuEA....hRFp..Ipcphcpsh...............tpsp..shshs...st...t.ls..hp.s.WuclSpsl................................................	2	2	17	64
+4266	PF04957	RMF		Ribosome modulation factor	Bateman A	anon	COG3130	Family	This protein associates with 70s ribosomes and converts them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells.	27.90	27.90	28.20	28.70	27.10	27.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.69	0.72	-4.28	27	514	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	498	3	92	194	24	54.70	67	89.99	CHANGED	MKRQKRD+hcRAas+GYQAGlsGRS+EhCPap.sh-s.RspWLuGWREuhpD+hsGh	....MKRQKRDRLERAapRGYQAGIuGRSKEhCPYQ.sLsp.RStWLGGWR-AMtDRss..ht.......	0	17	34	64
+4267	PF04321	RmlD_sub_bind		RmlD substrate binding domain	Waterfield DI, Finn RD	anon	COG1091	Domain	L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesised by four different enzymes the final one of which is RmlD.\	\	\	   The RmlD substrate binding domain is responsible for binding a sugar nucleotide [1,2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.59	0.70	-5.52	37	4012	2012-10-10 17:06:42	2003-04-07 12:59:11	12	20	2929	21	1194	32857	21491	276.30	30	91.82	CHANGED	Mp.lLlTGusGQlGp-Ltcthtt.pshslluh.s+s...........phDlscspultphl.........pph+Pc..lVlNsAAaTAVDpAEs-..-tAhtlNutGsttlAcust.phGs.LlalSTDYVFDGs........tsts.YpEsD.ssPhslYGpoKLtGEpAVhs..sss.cthllRTuWVY.ut...tGp..NFVcTMl+LA..tpccplpVVsDQhGsPThstslAcslhtlhpphhp........hGlaHhsssGt....soWasFAptIhcpsstps........cVpPlsospaPpsApRPt.SsLssp+hptshsh.h.s.WcpuLtchlpphht	..........................................................................................................................................p.lLls.Gu.s.GQ....LG....p......p........L.t.......p...........h.......h......s.........t.......t............s...............p.......h.......l..uh...sts.....................................................ph.D......l...s...s...........p........s.......l......p......p.....h...l.......................................p..p.....h.....p.......P........c..........l......l........l......N....s...A.......A........a.......T.......s.......V.....D.......t........A.....E.........s....-....................c......h....u..............h.......t.......l...........N.....s.......p....u..s...........p........p........l............A..........p..........s.............s...............p...........p...............h...............u..........u...............h.......l..........l...........a....l...S...T..........D.....Y......V.........F.........-....G.p................................t.s..t..s.....a.....p......E......s.........D.........t.........s.........s.........P..........h........s........h..............Y.......G.....p.....o...K....h.......t.......G....E.....p.......t.....l......tp..................hs...........s.......c............h..........h.........I..........l......R........T..........u.....W.......l.....a...ut....................hG..p.......N......F.......l......p.......T.......M.........l........c.....L.u........pp.......+................c...........p..................l......p........V......l........s...........D.........Q........h........G......s........P........T..........h....s......t......s...L...A..c.h.....h.........h.....p.....l....l...p.....p.t...t.t..................................hG.l.YHh..s..s..s..u.t................s..oW....a....-...a.A....p....t....lhc.t.s.sh.t.........................p.l.p...s....l..s..o.....s......p......a.....s.....t..............A........t.....R....P....t........S.....h...L...stp+.....h.p.t.t....h..........s..h...............h........s..Wppultphht...th..................................................................................................................................................................................................................................................	0	375	753	996
+4268	PF03035	RNA_capsid		Calicivirus putative RNA polymerase/capsid protein	Griffiths-Jones SR	anon	Pfam-B_1282 (release 6.4)	Family	\N	19.50	19.50	21.00	20.70	19.00	18.00	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.72	0.70	-4.55	34	896	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	582	0	0	699	0	183.40	57	98.34	CHANGED	MAGAhlAGLAu...DhluuulGoLIsAGANAlNQ+h-a......................c.Npp...........LQpsSFpHDKEMLpuQlpATppLQtchlsl+pulLsAGGFSssDAARuulsAPhT+l.lDWN...GTRaaAPs......ShpTTsaSGpFsssss............p...................ssssohpopST.Soslossstss..................osssSRTosWVpsQN............p.LpPahpuALpTsaVTPPSSp.uSSs.........uoVSTVP+tlLDSWTss.....FNT+RQPLFAplR	........................................MAGAFhAuLAu....sllusulGSLlsAGAsAlNQ+h-F......................-pNpp...........LQQASFQHDKEMLpAQlpATppLQpphhpl+puhLhtGGFStoDAuRu....AlsAPhT+s.lDWs...GTRYaAPs......upsTTh.uGtFoss.s.......................................................utssohhospT.sotluuss.ss..................hssosRTpsWlppQN............pslpPahpGAh.phsaVTPPuSp.uSo..........uo..VSTVPcth..Sa.s......FNTcR.PhFA...............................	1	0	0	0
+4269	PF00680	RdRP_1		RNA dependent RNA polymerase	Bateman A	anon	Pfam-B_32 (release 2.1)	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.51	0.70	-6.25	39	14992	2012-10-02 12:54:00	2003-04-07 12:59:11	15	154	6054	160	0	11808	1	228.60	22	27.06	CHANGED	l.....shss+stlptsshcshhssh.....pcPusLshtDPRhssth...........schths+thhph.h.tplssh.hpshpcshstlhphh.shshtphshtpshpsl........hcsLs.......hsTSsGhPYh........ttKK+chhsptsts........................................th...hhhpshphhtsp.hu.thlhhsslKDELRsh-Kl..................................ptsKTRhhpusPlssslss+hthsshssthhpp.shphshsVGhs..pttWsclhtpLsp..uphhhssDaSsFDuoloPhlhssl..hplhpphh........hphhpshhhphlssshthhcsplh..........clpsGhPSGpssTslhNolhs.lhhphshhchhtshphpp..................p.lc......hhs.YGDDhlluhs.phs.h.....hptlpp..............phtc.hGlphT...sDKops.......hpplsFL+Rph..phspsh...hhshhcpcpIhs.lp..Ws+sspspp.......................plpslshthhcs....spchh.p..clpchhtphlpttsht............Phhtphthcah.t	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..h................h.h......t....h........................................................................................h.........p.............h......l..............s....h....h..........h.t..s..h.h..........................h..tG..P..S.G.ssTo..No.hhp...l..h....h....h....h..t.....h.........p.h...h...............................................................hh....uDD.h....................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+4270	PF00978	RdRP_2	RNA_dep_RNApol2; 	RNA dependent RNA polymerase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_13 (release 3.0)	Family	This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins:     2A protein from bromoviruses     putative RNA dependent RNA polymerase from tobamoviruses     Non structural polyprotein from togaviruses	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.43	0.70	-5.80	36	2606	2012-10-02 12:54:00	2003-04-07 12:59:11	16	43	501	0	2	2727	0	250.60	22	29.18	CHANGED	psDhsls.lc..csplp.oc.psh..p.....pcshhtPslRous.p.....tRpsThp-s..LhAhpKRNhssPcLpcssshpphup.plscpFh..cshhspchhc........sshhss.tthspahsphpshptttl...ts.shhsL.pt...lshppYpaMlKsDlKshl-sohph..EhsssQTIsaacKhlsuhFuPlFpplscRlhtsLps.+llh.ssh....hss.hhscphphhss...hps......lElDhSKFDKSQschHthsphtlhctLGlss.lhsh.Wp.sh.......ccpohl.....p...Dhps..Glth.l.aQp+o..GsshTahuNT...l...lshshlupsh..s..lp...psphshFuGDDSLl...hshps...ts.spthsohaNhEsKlhc....h....sh....PYFCuKFLl..p..ss..sss.....hh.VPDPlKhlhKLGpcchhc.....phLp-hapShsDth+.a.c.hshhphhphshhchh+h..th.tshtsltphl.tuhstapsh	............................................................................................................................................................................................................................................................................................................................................................................................................................l...hpp...hhshaushh+.ltct.l....t.h..L..s...phhhhssh.........s..h.s.th.h.tsht........t.s.....hEsDastFDpo.Qsph......h.h.t.hEhhlh.......c.t.h..G......h......sp....llc........................h.....................t............h....oG...Th.hNT.........hs.hh....h....h....hh..........ht.........t........h...hh..GDD.hh....................................................................................................................................................................................................................................h..................................................................................................................	0	0	1	2
+4271	PF00910	RNA_helicase		RNA helicase	Bateman A	anon	Pfam-B_11 (release 3.0)	Domain	This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.37	0.72	-3.87	99	3937	2012-10-05 12:31:08	2003-04-07 12:59:11	17	83	1135	0	26	5004	845	96.30	36	6.53	CHANGED	lhlhGss.GsGKShhsph.lhptlh...t..................p.sslYs.tsssscaa.sGYp..tQslslhDDhspss.ss....p..htthhpllsossa.lsMAslccKu.h.FsSphllsooNh	.....................hlpGsP.GsGKShhssh.luptls.....................................t.s.sss.Y.......hs...s...c.s...ca.....a.....D.....G....Yc......t...Q.t...V..Vlh.DDh..s..pss...ss..........p...Dhphht..ph.l........soss...ahs.shAul.Ep.....KG...h.Fs.Sc.hllsooN......................................................	0	12	14	23
+4272	PF00940	RNA_pol		DNA-dependent RNA polymerase	Finn RD, Bateman A	anon	Pfam-B_1108 (release 3.0)	Family	This is a family of single chain RNA polymerases.	22.00	22.00	22.10	24.60	20.80	21.90	hmmbuild  -o /dev/null HMM SEED	405	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.45	0.70	-6.00	94	680	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	462	20	294	684	441	385.90	35	41.81	CHANGED	u+sL.GppGLcWLKlalANla....GhDK.hSh.........p-Rlpasc..cp..h..................cpIhcsA........cs.................................................................................Plpt....p.......aWhp......A-cPaQhLAsChElpps....h.....cpsss..ppa.....hSplPlaQDGoCNGLQHYAALGtDhhGAppVNLhP...u-..c....PpDlYotVuphVpctlp.....p-.................................................stpspphuphl..pst......lsRKllKpoVMTpVYGVThhGuppQlpcpLppht...p....................................................................................................................................tt.hhpsupYluphlhpulpphFsuAcpI.pWLspsAphlsp.ssps................................................VhWsTPhGLPVsQsY+...ctppp.plpos....lpshshpps.stsss..........sppKQt.................sAhsPNFlHSLDAoHhhhouh..pstc.......tslsFuuVHDSaWTHA...........ssl-p.MspllR-pFlclaup.s.llpcLtppappphtp................................................................................................................................................................................hphsslPppG.......s.hDlp...........plhcSpYFFs	.....................................................+.L.G..pGl.pWLKlHluNhh..........G..h.cK...hsh.........pcRhtasp..pp..h....ppI.hc.SA..pp.................................................................................Plps..pp.........WWhp.....A-cP..aQhLAsChEltpu....h.....cp.s.s.P..tpa........hSplPlaQDGoCNGLQHYAALGtD.hGAptVNLhs..............u-.p....PtDlYstluph.Vpphhp........p-..............................................................tttst.h...Aphl........tshlsRKllKpoVMTsV.YG............VT....hhGupp..Q.lt.cp.Lpph............................................................................................................................................tt.hhtsupYlsph.hhpu...ltphFpuu..ptl....pW...L.s.p.sA.ch.......lsp.p.ps...............................................................................................................................VhWsTP.l.GlPVhQs.Yp..p.t....p.p....tl.pss..........h.ps.h.hh.p....t..t.h...............................stpKQt............................................suhsPNFlHSLDuo...Hhhhoul.tstc................tsl.s.Fs.u.VHDSaWTHA...........sslsp.hsp.llR-pFlplasp...sllppLh.pph......tph.t............................................................................................................................................................................................................................h..hPtp.G.......s.h-lpplhpS.YFF......................................................................................................................................	0	102	176	254
+4273	PF03118	RNA_pol_A_CTD		Bacterial RNA polymerase, alpha chain C terminal domain	Finn RD, Bateman A	anon	Pfam-B_172 (release 3.0)	Domain	The alpha subunit of RNA polymerase consists of two independently folded domains, referred to as amino-terminal and carboxyl terminal domains.  The amino terminal domain is involved in the interaction with the other subunits of the RNA polymerase.  The carboxyl-terminal domain interacts with the DNA and activators.  The amino acid sequence of the alpha subunit is conserved in prokaryotic and chloroplast RNA  polymerases.  There are three regions of particularly strong  conservation, two in the amino-terminal and one in the carboxyl- terminal [2].	23.80	23.80	23.80	24.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.94	0.72	-4.56	121	5961	2012-10-03 02:11:09	2003-04-07 12:59:11	10	30	5358	22	1041	3553	2145	65.70	44	20.39	CHANGED	ppp.p..p...phhphsI--L-LSVRuhNCLK+ssIpTlu-Llphocp-Lhcl+NhG+KSlcE...IpctLpc	..........................c....php.lLhhsl--..L.-.Lo..VRShNCLKp..t.sIphluD...Llp..+...oE....s...-....LhKscNhG+KSLpE...lKchLt................	0	373	707	891
+4274	PF05066	HARE-HTH	RNA_pol_delta;	HB1, ASXL, restriction endonuclease HTH domain	Bateman A, Aravind L, Iyer, LM	anon	COG3343	Family	A winged helix-turn-helix domain present in the plant HB1, vertebrate ASXL, the H. pylori restriction endonuclease HpyAIII(HgrA), the RNA polymerase delta subunit(RpoE) of Gram positive bacteria and several restriction endonucleases [1]. The domain is distinguished by the presence of a conserved one-turn helix between helix-3 and the preceding conserved turn. Its diverse architectures in eukaryotic species with extensive gene body methylation is suggestive of a chromatin function. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as  hmC [1]. Bacterial versions include fusions to diverse restriction  endonucleases, and a DNA glycosylase where it may play a similar  role in detecting modified DNA. Certain bacterial version of the  HARE-HTH domain show fusions to the helix-hairpin-helix domain of  the RNA polymerase alpha subunit and the HTH domains found in  regions 3 and 4 of the sigma factors [1]. These versions are  predicted to function as a novel inhibitor of the binding of RNA  polymerase to transcription start sites, similar to the Bacillus delta protein [2,3].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.28	0.72	-3.63	67	1524	2012-10-04 14:01:12	2003-04-07 12:59:11	8	24	1377	1	259	816	13	68.90	34	20.55	CHANGED	hoht-sAhpVLcppu....cPhphp-IhcphhcpuLhpht............u+oPtsolsuplhs-hp...........pshFlcl....tsphuLtsh	....................h.ShIElAhslLcp+u.....csMsas-llscI.ps.hhtpp...............spplcspls.pFYT-LN...........hDGpFlslG...-NpWGLRsW.........................	0	72	138	195
+4275	PF04090	RNA_pol_I_TF		RNA polymerase I specific initiation factor	Wood V, Finn RD	anon	Pfam-B_43469 (release 7.3);	Family	\N	19.90	19.90	19.90	19.90	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.48	0.71	-5.04	10	106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	102	0	77	105	0	186.60	21	39.59	CHANGED	hhhs.lspss+cs+tpFllhspGhEVlP..........sshs-l+sa....pppHIspLssLLHlNlLRcNWslAY+hFsLLIRlPsVDIRsIWsLGlEILsplsppsss................cFh-Whsshao...s+ssFspsssp+.hAPVFRoGSRoHTPhYllo.LWslLlpsp.....................................ascLh-+LuEhlLpPPY.sDutlaFlhuhC+llcAs-LuscF	.........................................................................................sp.psh....+hpHlssLoslLHhslhctcaspAhRsaulLl....R......h....p......s....VD....lR..s..h..WulGsEILhptsppsst................................................cahphh.t.has.......tpt...t...............h......................h.h...hh..h...t......................................................................ht.h...htphh...Pa..t..hh.h.u.h.h.......................................................................................	1	20	40	65
+4276	PF01193	RNA_pol_L		RNA polymerase Rpb3/Rpb11 dimerisation domain	Finn RD	anon	Pfam-B_172 (release 3.0)	Domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer.  The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000).  Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037).  Rpb11 is found as a continuous domain.  Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null --hand HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.95	0.72	-4.85	218	7433	2012-10-02 13:35:44	2003-04-07 12:59:11	19	28	6156	190	1663	5625	2992	199.80	31	64.81	CHANGED	lphhhpu.stTluNuLR+hLlsphsslslsshpl.p..t....................................................................................................................................................................................................................................................................................................................................................................................................................................ttpp...............................................................................................hhlclpTs.Gsh........sPpcslpp.AhchLtpphp	...................................................................................................................................-PLE+GaGpTLGNuLRRlLLSS.lPGsAlTplcI-GVhHEaSol.GVpEDVhpIlLNlKtlsl+hpsccpphhplphpGsu.loAuDIhhssslchh....................................................................................................................................................................................................................................................................................................................................................................................s.thhhsshsptsphhhthphptthshssstpscpsptslGhl.lDuhaoPlp+lsYpVEssRVtpps...........DhDKLsl-l.Ts..G.ol...................sPc-Alpt.AA+ILt-pl...................................................................................................................................................................................................................	0	593	1066	1406
+4277	PF02150	RNA_POL_M_15KD		RNA polymerases M/15 Kd subunit	Mian N, Bateman A	anon	IPR001529	Domain	\N	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-8.06	0.72	-4.26	10	723	2012-10-03 10:42:43	2003-04-07 12:59:11	11	10	427	90	486	620	22	35.70	34	27.56	CHANGED	lcFCscCsNhLhspsc+psp....tCRsCsYcp.s-s.	...hpFCscCsNhL.h...s..c..cscpsph.......htCpsCsYpp.h.............................	0	142	257	398
+4278	PF01194	RNA_pol_N		RNA polymerases N / 8 kDa subunit	Finn RD, Bateman A	anon	Prosite	Domain	\N	24.70	24.70	24.70	26.90	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.35	0.72	-3.94	49	498	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	450	97	310	402	203	60.50	55	79.07	CHANGED	MlIPVRCFoC.G+llu.......chWccYhphlpp.....G.s.........ucsLDcLGl.cRYCCRRMlLoH......VD...lI-cll	...................................MIIPVRCFTCGKVlG.......scW-pYlphlps............shsc..........................................u-ALDsLGL.cRYCCR.RMlLoH......VDLI-clL.............	0	101	176	260
+4280	PF04990	RNA_pol_Rpb1_7		RNA polymerase Rpb1, domain 7	Finn RD	anon	Pfam-B_288 (release 4.2)	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 forms a substantial interaction with the lobe domain of Rpb2 (Pfam:PF04561) [1,2].	20.80	20.80	21.40	22.10	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.89	0.71	-4.45	42	792	2009-01-15 18:05:59	2003-04-07 12:59:11	7	76	658	90	242	733	168	119.00	55	10.85	CHANGED	TTL+pVTssopIYYDPDPpsTlIEEDp-aVpsaa.-hPD..t.-.s.....phSPWLLRlELDRcthhDKcL.oMpplup+IppsFu......sD.lplIaoDDN.A-cLVlRlRlhpsp...................................ct..-p-p.....c....-D...hFL+clEsphLsslsLp	.................TTLR+VTusTuIYYDP.............DPp.sT...VItEDpEaVslYY.EMPD........hD.so.........+hSPWLLRlELDRK+MsDKKL.TMEpI.A-KIptuFG....................-D.LssIas-sN.....ucch......lhRlRhhttt...................................................t.tpt...........p.....t.....hL+ph.tphLtth.L...........................................................................................................................................................	0	88	139	207
+4281	PF04563	RNA_pol_Rpb2_1		RNA polymerase beta subunit	Finn RD	anon	Manual	Family	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure.  This domain is also known as the protrusion domain [1].  The other lobe (Pfam:PF04561) is nested within this domain.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null --hand HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.23	0.71	-5.40	21	11314	2009-09-13 15:18:01	2003-04-07 12:59:11	10	107	8899	140	1837	8858	4389	301.50	26	35.23	CHANGED	sLlc.Qh-SFstFlppsLp.............-hlpp.sslpspst.............phchplphtplpls.cPphs-..........h.Pp-A+hRslTYSutlYVshchphpps...............................tchpppcValGclPlMhco....h.t....c...htp.....tGhFIlNGsE+VllsQ.hhusshhas.cpcpsuhhshssshhophtttpph.tsppsplht+hspstthshhshhhthths.splhhthhhhth.hph.pphthphptpth....................pthhh.spt.shsthttphhphths+cpphttshphhphphh.+lsstpsscptpshhlshhhphLlhhphshtp.DDhDHhuN+RlchsGpLLps.F+hhhp+Lp+sl+pphptshpcs..........hs.pshlpu.psIosslcphhuou	............................................................................................................................................................................................................................................................................................................h...............................................................h....h....t........h........s..h........................................-s...........cs.hsa..ts.lh..h.hth.....t..................................................................................................p.t.h.....h.G.p........hPhMh..................................................................................................................................................GhFllNG.E+lllsQ.hhusshhh..t.tt.t...h........................h....t......h...hh.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....hh..h.hhh.h....h..DDhcphss+Rlc.su-Llp..sp...a..R.....h....u...L.s...R...hp...+........s.V.+c.ch...s...t..t..s.cs.....................................hs.P.p..p...hI.....s.....h....+....s....lsuulKpFhuou.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	649	1155	1555
+4282	PF04561	RNA_pol_Rpb2_2		RNA polymerase Rpb2, domain 2	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure.  This domain is also known as the lobe domain [1].  DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble [1].  Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.11	0.71	-4.88	22	13001	2009-09-11 22:08:18	2003-04-07 12:59:11	9	96	7019	145	2482	9371	4016	126.70	21	18.82	CHANGED	psstlhhppchspssh..................thhssshhptputhhphchstpthhhsh.phppcIslhllh+AlGh.sDp-Ilptls..a..............s..hh.hhh.phpct.sh.op-pALphltp.......hht.sc.splptupchl............t.lt+.pls.+lshp.s.csp...ps..lhhhlctLltht.hshtp.DDhDHhuN+Rlc	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t....................s........h.t..........................................................................................................................................t......h...p.l.......................................t.....................................................................................................................................................................................................................................................................................................................................................	0	840	1548	2077
+4283	PF04566	RNA_pol_Rpb2_4		RNA polymerase Rpb2, domain 4	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain [1].	21.60	21.60	22.30	21.60	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.98	0.72	-4.16	12	7585	2009-09-11 14:40:16	2003-04-07 12:59:11	8	53	5403	96	610	6531	395	61.70	56	13.64	CHANGED	ValNGsllGspcsPccLspplRphRRpGclss..lulhhs.cpp-l+I.TDuGRhsRPLlIV-N	............lFVNGVWlG...V.H.p.....DP..t...pLVpslpcLRR...+..........s.................l......s..........h....EV.Sl..l..R..DI.....R.....-..........RE.....h+IaTDAGRVhRPLFlV-.........................	0	212	356	512
+4284	PF01191	RNA_pol_Rpb5_C	RNA_pol_H; 	RNA polymerase Rpb5, C-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	The assembly domain of Rpb5 [1].  The archaeal equivalent to this domain is subunit H.  Subunit H lacks the N-terminal domain.	21.30	21.30	21.70	22.10	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.23	0.72	-4.39	64	636	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	504	98	378	576	240	72.50	49	38.79	CHANGED	lNlscHpLVPcHplLoc-EtpplLpcYplc.pQ............LP+IhtoDPls+hh......Gh+.GsVl+IhRcS...pTuGchlsYRlVl	.........................lNITcHpL.VP.c.HhlLopE.EppcLLp+...Y.cl.+.-.sQ..............................LPRIptsDPVA+Yh.......................Gl++G..pVVKIlRp.S...E.TA.G+YloYRlV...............	0	129	223	317
+4285	PF03871	RNA_pol_Rpb5_N		RNA polymerase Rpb5, N-terminal domain	Finn RD	anon	DOMO:DM07083;	Domain	Rpb5 has a bipartite structure which includes a eukaryote-specific  N-terminal domain and a C-terminal domain resembling the archaeal RNAP  subunit H [1,2].  The N-terminal domain is involved in DNA binding and is  part of the jaw module in the RNA pol II structure [3].  This module is important for positioning the downstream DNA.	21.00	21.00	21.00	21.20	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.06	0.72	-3.58	36	436	2012-10-11 20:44:43	2003-04-07 12:59:11	9	10	315	91	270	395	9	95.30	34	42.69	CHANGED	Mssp.......cpht.RLaRshRTlhEMlcDRGYhl..spcElsholcpF+ppasc..............pspRschph.sp.psc...................ssspIaVhFs....-psplGlKsl+sasp.php	..................c...pEhh.RLaRhp+Tlh........p..Mh+DRGYhV..spcEl...s..o...L-cF+ppau-t.t......................pPpRpcLsh.ssps.s-....................sssplaVhFs....--sp....VGlKsl+taspph..............................................................................................................................	0	97	154	223
+4286	PF01192	RNA_pol_Rpb6		RNA polymerase Rpb6 	Finn RD	anon	Prosite	Family	Rpb6 is an essential subunit in the eukaryotic polymerases Pol I, II and III. This family also contains the bacterial equivalent to Rpb6, the omega subunit.  Rpb6 and omega are structurally conserved and both function in polymerase assembly [1].	20.60	20.60	20.80	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.43	0.72	-4.22	57	4597	2009-01-15 18:05:59	2003-04-07 12:59:11	17	6	4471	137	1177	2396	1900	54.00	32	56.84	CHANGED	cclhshhss+YclshllupRAcp..lp.hsssshl.pcsp....+PlhhAlpElscshhp.pl	..............pchlc+lss+apLVllAA.+RARQ...........lp..t..G...t...s..........sh..lt...tpss.................KssshALcEIt..pshls........................................	0	378	740	987
+4287	PF03876	SHS2_Rpb7-N	RNA_pol_Rpb7_N;	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	Finn RD, Anantharaman V	anon	Hand	Domain	Rpb7 bind to Rpb4 to form a heterodimer.  This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation[1].  This family includes the homologs from RNA polymerase I and III.  In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA [2]. The N terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction [3].	20.90	20.90	20.90	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.02	0.72	-3.85	145	1033	2012-10-02 11:08:51	2003-04-07 12:59:11	12	19	491	64	703	949	87	71.80	24	30.62	CHANGED	pchlplsP.phhs...........................................shppslh.......ptLhpphts+.................hstp......h.G..........lllulhcl..pp................lsc....................Gpl..h.sss..GssahpVpachllF	.............................t..hlpltP.phhs............................................phppslp.......pp.L...pch.ts.p.................sstp........h.G...........hllulhcl...pp...lsc....................................GhI..h..sGs.....Gh.s......hhp.......V.pachlVF...............	0	224	387	571
+4288	PF03870	RNA_pol_Rpb8		RNA polymerase Rpb8	Finn RD	anon	DOMO:DM07082;	Family	Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III.  Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.	25.00	25.00	26.50	26.40	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.78	0.71	-3.98	7	366	2012-10-03 20:18:03	2003-04-07 12:59:11	10	4	309	91	251	321	4	131.00	41	90.57	CHANGED	-DIFpVpslDP-GKKa-+VSRlpspSpshc.McLhLDINoplYPlthsDphpLslAooL.h.Dss.ssu....pasP..http.o.hsDpaEYlMYGKlY+lE..Ess..tts.+lu.sYsSFGGLLM+LpGctppLpsFclDpplYLLh++	.............................-DhFsVpslDs...pK..aDR............VSRlpspS.p.s.h.c..hplhLDlNs-lYP.lphu...........D.phplsLAoTL..p.D...G...s.s...-su...................taps........ts.pc...o....hADpa-YVM.aGKlY+.hE.......Ess.....tss..pls.sYsSFGGLLMpLpGshppL..p.s..hclDp.lYLLh++...................	0	84	143	210
+4289	PF05158	RNA_pol_Rpc34		RNA polymerase Rpc34 subunit	Finn RD	anon	Manual 	Family	Subunit specific to RNA Pol III, the tRNA specific polymerase. The C34 subunit of yeast RNA Pol III is part of a subcomplex of  three subunits which have no counterpart in the other two nuclear RNA polymerases. This subunit interacts with TFIIIB70 and is  therefore participates in Pol III recruitment [1]. 	25.80	25.80	25.80	25.80	25.50	25.60	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.02	0.70	-5.25	20	415	2012-10-04 14:01:12	2003-04-07 12:59:11	7	7	320	3	292	406	4	252.70	25	92.27	CHANGED	MAsss........pls-ltpcla-thhpp...sphhoQp-Lpsh..hspsshsplhsslppLl-ppLlcLlp..pssc.Lta+hlsp--ApK..........hsshus-Eu.LVYshI-uoGscGIWs+sI+s+oN...Lppshlp+s........LKoLEo+p....aIKSVKsVchPs+KhYMLasLpPSc-lTGGsWF..oD.p-LDspFIssltphlhpalspKoh.sh........................................................................tptpthshssshpuYsTstplhpalscsu..los.........VpLopcDIppLl-sLlYDG+lEplpss.....t.hpsh+sshpshhph.p.........................................s.hsssshspsPCupCPVFchC..sssusloPcsChYhccWLp	......................................................................................................................................t....................hht.h......t......thh..p.l.t.............p.t.hh.hhp..Lhp.t.hphhp.........tsst..lhaphht..pp.t.tt...............................hpsh....sspEt.llYphIcpuGppGIWp+sl+h+os...L..p.....lp+h........LKsL.Es.+.p....hIKsl+.sVp............ts..p+KhYhLhsLpPs.plTGGsWa..sD.tph-tpFlp.ltp.hhpalpppt................................................................................................................t..h.....s...o.pplhphlpp.t....lsp....................hpLs.pslppllpsLlhDspl-.hh.s...............hh...t.............................................................................................................................................................s..s.h..hp..hP..Cs..CPlhp.C..t.su.l..s..s.ppC.YhppWh......................................................................	0	108	172	245
+4290	PF05132	RNA_pol_Rpc4		RNA polymerase III RPC4	Wood V, Finn RD	anon	Pfam-B_18856 (release 7.7)	Family	Specific subunit for Pol III, the tRNA specific polymerase.	22.10	22.10	22.60	24.40	21.30	22.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.57	0.71	-4.16	36	332	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	269	0	241	326	2	126.50	25	30.42	CHANGED	.csphalhQlPshLPshhsssssp...........................................pptpcsppspppppsspptpssspt.......hppl........pGplGKlhl+KSG+lplclG.slshD.........................lshGssssFLQ-llslss..........tcps................phhsLGplptKhllTP-h	...............................p..tphhhhQhPshLP.h..stt.t.........................................................tt.tt....tt..p.t..pt..ttp.t.stpt................s.sh.pph......................spG.tlGKlhl+KSG+lplpl.........G..s.......lhhD................................................ls....hG.s...ss...sFlQ-llslst.....................cps..............................phhs...LGplpp.+.hlsoPch......................	1	76	128	199
+4291	PF03431	RNA_replicase_B		RNA replicase, beta-chain 	Finn RD	anon	Pfam-B_4422 (release 6.6)	Family	This family is of Leviviridae RNA replicases.  The replicase is also known as RNA dependent RNA polymerase.    	25.00	25.00	25.00	25.00	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-13.04	0.70	-6.30	6	321	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	25	10	0	316	0	252.20	52	80.15	CHANGED	lhspsslt.slus-Lh.shs...........ShuhsuhD.ssDsFc.lsYL+sElLoKa-sauhG.-s....culAatKFLsAEpcCtlpNpchahh.sasEp..hShuEusI+hu.RphIu+LLu-.ssh.shhc+CRFSGGAopsssRpautPuhKaAt.....ptslTsRAlcYshAh+cssu...........s-s+hhclsssN+ssTVPKNuKsDRsIAhEPshNMahQhGlGuhIRcRLRphGIDLNDQTlNQcLAppGSlsssLATIDLSuASDSISlcLVc.LLPPcaachLhcLRSshGhl.DG+llpaEKlSSMGNGaTFELESLIFAAlARSlspllthcsuslulYGDDIIlPocssssLh-VhpaVGFpPNp+KTFosG.PFRESCGKHYFpGVDVTPFYI++sIssLsDLhLlLNplhRWuTlsGlhDPRsasVapKYt+hlP+hLptss...PDsYusuAhlstshhsshstp+tasRhhshlhchtR.h...............chs-hhSYha-hhuch.shhcsu...ss.hs.tps.hhh..t.hp+...h....sots.uhhcshssSc	................................................spDL..thh...h.......uhs.sphD.pscsFp.lsYL+sElhoKasshs.u.sp...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+4292	PF01876	RNase_P_p30	DUF53; 	RNase P subunit p30	Enright A, Ouzounis C, Bateman A, Dlakic M	anon	Enright A	Family	This protein is part of the RNase P complex that is involved in tRNA maturation [1].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.49	0.71	-4.97	62	477	2012-10-03 00:45:34	2003-04-07 12:59:11	11	9	410	3	326	499	10	141.70	25	49.82	CHANGED	hsRlslhhsss....h.....tptlsphpp....taDllulpPtspcshphAspsh..c......lDllohshst...+hshhlc+hhhphAhc+Gl.tlElsaushl...................ps..shsRpphlssh..ppllphs+p..pslllSSuApshhplRuPhDlhsLst.hh...G.....lspscucpuls.p.	.....................................hpRlslh.hsss...t.t........ttths..phhp....ta..DllAlpPts....pchhphAspsh....c.....................lDllshshst......+hs.h.h.............hc.+hh.l.ph..Alp+Gl.thElsaushl..............................ts..sttRpphls...ss............tplhphs+u...........+slllS..SsAp..p...............h..plRuPhDlhsL......ht.lh.G.....lspppuptuls...........................................	0	104	184	268
+4293	PF01900	RNase_P_Rpp14	DUF69; 	Rpp14/Pop5 family	Enright A, Ouzounis C, Bateman A, Cerutti L, Dlakic M	anon	Enright A	Family	tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule associated with at least eight protein subunits, hPop1, Rpp14, Rpp20, Rpp25, Rpp29, Rpp30, Rpp38, and Rpp40 [1]. This protein is known as Pop5 in eukaryotes.	21.50	21.50	22.20	22.00	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.35	0.72	-4.13	65	500	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	381	7	356	486	8	109.40	22	67.85	CHANGED	RYllhcllh....................................sslsp.....................c.slhptl+pulpphaG-hGsups....sstlhshahss.oth.....uIlRssRsthchlhuuLshlsplss...................ptlhlcsltlSG...TI+psccthlch	...................................................RYlhhplhh...................................................plst......................p.slhphlcpultphaG-hGsuts....................t.tl..p..l......hh....h....sstTth............sIlR.sp.+pthchlhuuLsh.lsplps..............................psshhpslplSGTl+pspphhh..........................	0	109	192	282
+4295	PF00074	RnaseA	rnaseA; 	Pancreatic ribonuclease	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.	21.70	21.70	22.10	21.70	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.09	0.71	-3.83	108	847	2009-01-15 18:05:59	2003-04-07 12:59:11	15	3	206	473	241	891	0	119.30	33	78.61	CHANGED	ppsshppFppQHls........sss..s..............hCN.phMppt.phhp.t....pCKshNTFlHps..hssVpulCsptsssCp...tppNCapSpsphplTpCplous.st......hssCpYpsoppp+h.lhVAC-sp...........lPVHhD	................................t..othppFt.pQHhs........sss..sp.................hCN.phMpp+.shppt......pCKshNTFlHps..hssVpslC.tp...ts..l.sC+.........ss.pp.NC..apSpsthplTsCclosusp......hPsCpYpss..t.p..p+.a..llVAC-ss...........lPVHhD..........................	0	15	18	39
+4296	PF00075	RNase_H	rnaseH; RnaseH;	RNase H	Eddy SR	anon	Swissprot; SCOP and HMM_iterative_training	Domain	RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-11.40	0.71	-3.81	65	16967	2012-10-03 01:22:09	2003-04-07 12:59:11	19	181	3870	344	1941	16858	2641	121.40	50	20.38	CHANGED	sps.hshaTDGSs.tp...stpu...tAGh.lh.pps...............+..pht.tsls.....tsosQp.uElhAlhtALc.s......ts........ppls.....IhTDSpYl......hp.lhp.......................................sh.p.p.tps....lhs......plhphl...hp.ppp.lhltaV.uH.pGh......s.GNchADcLAppusp	............................................................................s..t.shYs.DGAsspp..............sphG.........pA.Ga...Vs...s+G.................................+......pcs..hsLs..........cTT...NQ.+....s.ELp.A...l.hL...A....Lp...D......SG.............................scVN..........Il..T.DSQ..Ys.....lG.....IIp.........................................................uQPs....c...SE.S.........t.lVN............QIIEpL.............I+...KEc...V..Yl.uWV....PA...H..KGI...............................G.GNE....pVD+LVStGI.R..........................................................................................	0	638	1217	1694
+4297	PF00773	RNB		RNB domain	Bateman A	anon	Pfam-B_1009 (release 2.1)	Domain	This domain is the catalytic domain of ribonuclease II [1].	20.30	20.30	20.40	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.05	0.70	-5.15	86	6644	2009-01-15 18:05:59	2003-04-07 12:59:11	14	56	4239	12	2000	5433	2047	308.20	33	41.36	CHANGED	RpDL..pch........hhh.oIDsts.scD....hDDAl................plcphs.sGt............................aplhVHIADVopalp.s........oslDp.cAtpRus.........................olYLssp.slsMLPppLu..p....slsSLtssp......................................c.Rhshoshhpl.spp.Gp.......l.ts...hchttulIcspt+loYcplpphlpsttpt.......................................tppLptLh....p.luptlcppRhpp.........Gulph.s.hs....-h.................................ph.l.....................sp......pspshshhhhp.....................ps.ucpllcEhMlhANpssApal.......t.pp..thsslaRspstPs.p........th.phhphh.........................ht..ttt...........htphht........psp..p.hl.......phhlh+sh...ppupY........sspsh.............HauLuh....stYo+aTSPlRRYsDLlsHR.LpthLpp	..........................................................RhDL...Rsh...hh.TID..s.ts..u+D......hD..D..A..l.........................................................................hs....c.pht....sGt............................acLhV............t...........IADVohYVp..s..................................osLDp.EAh..pRu.s.............................SVY..h.s.........s.....p...s...l.P...MLPcpLS.......s.............slCSL....p...Pp........................................-..Rhshssthpl..stp...Gp.................................l...hs......hc..hh.......pull....c.........S..p.t..+.h..oYspVpp..hl.p...s..p.pp.ttt.................................................................................................lhtpl.p..Lt....p..ltphLp.p.tR.h.p+.........................Gu.lsF..-..ps...................Eh....................................................................................+hh.l..................................sp................psc....p.lh.pp....................................Rp.uc.+llEE...hMlhAN.ssA..chl.....................p...ct........thss.laR.l...H.p.t.Ps.c...........phpphhphlt................................................hhth.ht.t..................................shpphhpt...............htsps...tth.l....................pph.hhR.sh.....ppAtY....................................................................sscsh..s.......Ha.GLuh....................phY..sHFT......SPIRR.Ys.DLllHRhl+thl..t.........................................................................................................................................	0	677	1244	1691
+4298	PF02508	Rnf-Nqr		Rnf-Nqr subunit, membrane protein	Mian N, Bateman A	anon	Pfam-B_1638 (release 5.4)	Family	This is a family of integral membrane proteins including  Rhodobacter-specific nitrogen fixation (rnf) proteins RnfA and RnfE [1] and Na+-translocating NADH:ubiquinone oxidoreductase  (Na+-NQR) subunits NqrD and NqrE. 	20.70	20.70	20.90	20.80	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.31	0.71	-4.71	128	4543	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1639	0	935	2710	1506	193.80	38	92.91	CHANGED	hp..ph...plhhsulhhsNsllsphLGlCPhLAVosplpsAlGMGlAsshVlshSshhlull+phl..........................................stlRl.saIhlIAuhVpll-hl...lcu......as..sLYpsLGIFlPLIsTNChlL........GRA-hhAp+................pshhtShlDG.lGsGlGFslsLllluulREhlutG..shh....t..................s.sh.pshslhllssG....AFhshuhllt	................................................................................................pchhplhlsslhhNN.sLlp..hLGlCP.hLA.Vo.pplp..sAlG.hGlAsThVlsloshsspLlcpal...........................shl..Rhlsal.hlIAulVph.l-hl...lct.au...sL..Y.ps..LGI...FlPLIs...TNChll........G.tA....hhsp+...................p.shhpShl..G.husGlGaslslllluulRE.hlusus..l..........................stsh...pshsl..sh..lssG........A.Fhuhuhll.h..........................	1	309	603	792
+4299	PF03259	Robl_LC7		Roadblock/LC7 domain	Mifsud W, Bateman A	anon	Aravind L	Domain	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	22.20	22.20	22.20	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.46	0.72	-4.42	41	1879	2012-10-02 21:07:43	2003-04-07 12:59:11	12	15	656	43	934	1705	25	90.00	22	65.84	CHANGED	hs.hlhphhtpssulpsslllss-Glslst.....shssscscplAAhsuulhuhuctsspphs..ssplcphhlcscpshlhlsssus...tshL.slls	..............................h.phh.p.p.ssG.lptsllls.s..D....G..lhlss.................sh.sp.s..s.u..........-....p..........l.AA.l.s...u...ul.h...uh.ups.....su.......pphs.......t........ss....lp.phhlchcp.....u.h.lh..lhss..uc....tshL.slh....................................	0	317	624	826
+4300	PF00480	ROK		ROK family	Finn RD	anon	Prosite	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.99	0.71	-4.45	14	15339	2012-10-02 23:34:14	2003-04-07 12:59:11	15	52	3744	43	2992	10332	2028	179.30	24	53.05	CHANGED	ulDlGuT+lthslhs.suplltpcchsT.....ssspthlsslsshlpch.sphs.......ululussGhlspsp......hlshsPp..hshtc.hslhpplcpchslPVhlpNDANsuAhuEphhssupshpshlhloluTGlGuGllhss+lapG.spG.AGElG...Hhhhs.p...........t.hCsCGpp.GClEshASGpAl	.......................................................................................................ulDlGuo.p.l...p.....h..u..l....h.....s................s............u........p........l....l....t......c.....p.....p......h..s.ss.............pss....p....p....h...l....p....t....l....h....p.....h..l....p....p....h.h..t..p...ht..........................ul.G.lu.hP......Gh..lc....p.p................sh.l...h...t...s..s.p.................s.a....p.......s....h....s..........l...t....p.....t....L.........p........p........p......h............s............l...........P........l......h...l.p....ND..ss..s...s..A......l...u......E.............h.............h.............h....................G.............s.............u.......p.....s.....h..........p........s.....h.l......h..l.............s.............l.............G............T...G.....l.....G.u..Gl....l...h.......s.G...c.....l.h...p..G...t......ps..tu..G.E.lG.........H.h..h..h..s....t......................................t.....C....C..Gp......h...G..ClEshhut.s.................................................................	0	1016	1988	2532
+4301	PF02027	RolB_RolC	Glyco_hydro_41; 	RolB/RolC glucosidase family	Bateman A	anon	Bateman A	Family	This family of proteins includes RolB and RolC.  RolC  releases cytokinins from glucoside conjugates [1]. Whereas RolB hydrolyses indole glucosides [2].	21.30	21.30	25.80	22.50	18.50	21.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.15	0.71	-5.13	41	119	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	15	5	14	115	0	190.50	20	62.83	CHANGED	hspstapsh.slphlpssp.cLctpLppAhpsapshhppslh.htpthh..h..............................t.hs.-hhh.spphhYlYssppphpphhp.s+hlspsu.spullAsslPPYppslohtthhphhNpls.........hsspps.pchsaFlAl.hPsssFhct.phplpstpst.hhhsFaspp..............................ss.hsa-.l...lAhGcshh	......................hshapsh.clphlpstt.cLptpLppAhpsacshhppslh.h.pth.....................................................h.hs.-hhh.stphlYlYssppthpphhp.p+.ls............pss.tpullAsslPPYppslohtphhphhNpls..........sst..psspchsaFlAl.hPossFhch.ph.lpstp.stphhhsaaspp...............................st.hsa-.l...lAhGpshh...........................	0	8	14	14
+4302	PF01815	Rop		Rop protein	Bateman A	anon	PSI-BLAST	Domain	\N	21.20	21.20	21.20	51.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.01	0.72	-4.52	12	216	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	168	35	7	146	14	57.70	73	91.23	CHANGED	MTKQEpsALNMAKFI+uQo.LLLLEKLspLD...LDccAs.CE+LHEpAEpLappLusRlt.p-.p	MTKQEKTALNMARFIRSQT.LTLLEKLNELD...ADEQADhCEpLH-cA-ELapSh.sRFts-sp....	0	1	3	6
+4303	PF00980	Rota_Capsid_VP6		Rotavirus major capsid protein VP6	Finn RD, Bateman A	anon	Pfam-B_1047 (release 3.0)	Family	Rotaviruses consist of three concentric protein shells.  The intermediate (middle) protein layer consists 260 trimers of VP6.  VP6 in the most  abundant protein in the virion.  VP6 is also involved in virion assembly, and possesses the ability to interact with VP2, VP4 and VP7 [1,2].	25.00	25.00	33.60	40.00	24.50	17.70	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.15	0.70	-5.83	3	1454	2009-09-11 12:38:02	2003-04-07 12:59:11	12	1	356	40	0	791	0	234.90	80	99.79	CHANGED	MDVLYSLAKTLKDARcRIVEGTLYTNVuDIIQQsNQlIsTLNGSTFQTGGIGNLPlRNWsFDFGpLGTTLLNLDANYVENARTTIDYFIDFIDuVClDEMVRESQRNGlAPQS-oLRpLAuuKFKRINFNNSSEYIENWNLQNRRQRTGYlaHKPNIFPYsNSFTLpRSQPtHDNlMGThWLNsGSEIQIAGFDSoCAlNAPuNIQcFEHlVpLRRsLoNATloLLPsAPRlopPsVIPoADGtTTWLFNPVILRPNNVpVEFLLNGQlIssYQARaGTlsARNFDSIRISFQLlRPPNMTPuVsALFPQAuPFsHHATVGLTLRIESAoCESVLuDANEshLSIVTulRQEYAIPVGPVFPPGMNWTELLoNYSsSREDNLQRlFTVASIRSMlI	...........................................................................................................................................................................................................................................................sstTTWaFNPlIL..RPNNVEVEFLLNGQIINTYQARFGTIlARNFDTIRLSFQLMRP..P..NMTPAVsALFPQAQPFp.HHATVGLTLRIESAVCESVLADAsEThLANVTuVRQEYAIPVGPVFPPGMNWp............................................	0	0	0	0
+4304	PF01525	Rota_NS26		Rotavirus NS26	Bateman A	anon	Pfam-B_762 (release 4.0)	Family	Gene 11 product is a non-structural phosphoprotein designated as NS26 [1].	21.10	21.10	21.50	21.10	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.45	0.70	-4.55	6	556	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	255	0	2	356	2	185.60	87	99.47	CHANGED	MSDFGIN...LDAICDNV++spSsScTuSQlSNRSSR+MDFV..D-EELSTYFNSKu..SVTQSDSCSNDLssKaSIIoEAVlCDESAHVSADAlQEK-Eo....lsQlDaslMKWMhDS.DGIslNGGlNFo+uKSKsp....................cpEschT-.KScTNl.sasSlsIsSslGtFNPIppplKhEAls-hFEDEDs-sChC+NCPY+EKYhKLRpRMKsVLlDhIsEM	...........MS.LSIDVTSLPSIS.SSIFKNESSSTTSTLSGKSIGRSEQYISPDAEAF.NKYMLSKSPEDI.GPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSNVGCDQlDFSLsK.......GIsVsANLDSCI.SISTsp....................KKEKSKKD.KSRKH...YPRIEADSDSEDY..............VLDDSDSDDGKCKNCKYKKKYFALRMRMKpVAMQLIEDL...................	0	0	0	1
+4305	PF02509	Rota_NS35		Rotavirus non-structural protein 35	Mian N, Bateman A	anon	Pfam-B_1677 (release 5.4)	Family	Rotavirus non-structural protein 35 (NS35) is a basic protein which possesses RNA-binding activity and is essential for genome replication [1].	25.00	25.00	120.20	120.00	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.02	0.70	-5.71	3	493	2009-09-11 00:14:00	2003-04-07 12:59:11	9	1	240	7	0	353	0	301.10	90	99.67	CHANGED	MAELACFCYPpL-cDus+ahPaN+pAIKCMLoAKVDKccpSpaYDTIlYGlAPPPpFKKRFNTs-NSRGMNYETDMYsKVAsLLs-lLNuIKlsp-K.sA-IlusVISVRHLENLlLRIEN+DDILScsscLllKSVLIAhGLlKEsETTsTAEGGEIVFQNuuFTMWKLDYpSH+LMPIhDsNFlEYKITlNccsPIsD+cV+ELlAELRWQYNKFAVITHGKGHYRVV+YSoVANHADRVYuTFKSspK+GssacFN-LDpRlIWsNWtAFluSMpsGsTLEluK+LLFoKMK.sSsoFKGlTT-RKhDEVShlG	...MAELACFCYPHLENDSYKFIPFNsLAIKCMLTAKVDKKDQDKFYNSIVYGIAPPPQF+KRYNTsDNSRGMNYETsMFNKVAlLICEALN.SI.KVTQS-.VANVLSRVVSVRHLENLVLRKENHQDVLFHSKELLLKSVLIAIGQSKEIETTATAEGGEIVFQNAAFTMWKLTYLDHKLMPILDQNFIEYKITLNEDKPISDlpVKELlAELRWQYNRFAVITHGKGHYRVVKYSSVANHADRVFATYKNNsKSGNshDFNLLDQRIIWQNWYAFTSSMKQGNTlDVCKKLLFQKMKQEKNPFKGLSTDRKMDEVSHVG....	0	0	0	0
+4306	PF00981	Rota_NS53		Rotavirus RNA-binding Protein 53 (NS53)	Finn RD, Bateman A	anon	Pfam-B_1048 (release 3.0)	Family	This protein is also known as NSP1. NS53 is encoded by gene 5.  It is made in low levels in the infected cells and is a component of early replication.  The protein is known to accumulate on the cytoskeleton of the infected cell.  NS53 is an RNA binding protein that contains a characteristic cysteine rich region [1].	22.10	22.10	24.10	24.10	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.89	0.70	-5.84	14	573	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	251	0	0	494	0	455.80	70	99.18	CHANGED	MATFKDACaHY++lsKLNptlLKLGANssWRPuPssKhKGWCLDCCQaT-LTYCpGCoLaHVCQWCsQYsRCFLDsEPHLLRMRTF+ssITKEDLpsLIsMYshLFPINc+IVsKFhsslKQ+KCRNEahhpWYNHLLhPITLQALslcl-.sclYYIFGYYDsMsptNQTPFpFVNhIshYD+LLLDDlNFcRMuhLPssLQppYAhRYFSKSRFlSpph+plphSDFScphlp.spcsPspthplhRNsop.......hcWNcpCc....LlpstpsYhshhpTSapEpYsVSspshhasptKLphlS+hhKPNYlsSNHtpsAocV+sCKWCslsssapsWpDFRl+clYNslhsFIRALhKSNsNVGHCSSpEplYthl+slhhhspscpaspolpplFshL-PV-lssscYlLhsaplsa-lhsllhpslpsc.lPpILols-htsIlpuII.cWFDlchMRchPhsstoTscL+cLpccscLs-EYDhhlSDsE	....MATFKDACYaYKRINKLN+sVLKLGVNDTWRPSPPTK..YKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYsRCFL..D..s-PHLLRMRTFKNEVTKsDLhNLIDMYshL....F....PINp+IVsKFIssTRQHKCRNEChsQWYNHLLMPITLQSLSIELD.GDVYYlFGYYDsMpslNQTPFSFsNLlDhYDKLLLDsVNFsRMSFLPssLQQEYALRYFSKSRFISEp.RKClsD.HFStNVlE.NLHNPSFKlQITRNCSE.....hSs-WNtACK....LVKshssYFslLKTSHlEFYSlSTRCRhFTQaKLKlASKhIKPNYlTSNH+TsATEVHNCKWCSINNuYpVWNDFRlKKIYDNIFNFLRALVKSNsNlGHCSSQEKIYEalcDVLsVCD-E+WKhuVscIFNCLEPVELssVcYVLFNHElNWDVINlLVQSl.GK.VPQILTLsDllhIhpSIIYEWFDIRYMRNTPMTTFTlDKLRpLpTtsKTV.-YDSGISDVE................................................................................	0	0	0	0
+4307	PF04866	Rota_NS6		Rotavirus non-structural protein 6	Mifsud W	anon	Pfam-B_4831 (release 7.6)	Family	\N	25.00	25.00	45.80	45.80	19.10	17.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.30	0.72	-3.98	12	253	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	198	0	0	89	0	91.00	90	99.27	CHANGED	MN+L.QRQLFLENLLVGVNSTFHQMQKHSINTCCRSLQRILDHLILLQTIHSPAFRLDRMQLRQMQMLACLWIHQ+NHDLQsTLGAIKWISP	.MNRLLQRQLFLENLLVGVNShFHQMQKHSINTCCRSLQRILDHLILLQTIHSPAFRLDRMQLRQMQhLACLWIHpHNHDLQATLsAIpWISP.....	0	0	0	0
+4308	PF01665	Rota_NSP3		Rotavirus non-structural protein NSP3	Bashton M, Bateman A	anon	Pfam-B_1010 (release 4.1)	Family	This family consist of rotaviral non-structural RNA binding protein 34 (NS34 or NSP3). The NSP3 protein has been shown to bind viral RNA.  The NSP3 protein consists of 3 conserved functional domains; a basic region which binds ssRNA, a region containing heptapeptide repeats mediating oligomerisation and a leucine zipper motif [2]. NSP3 may play a central role in replication and assembly of genomic RNA structures [2]. Rotaviruses have a dsRNA genome and are a major cause cause of acute gastroenteritis in the young of many species [1]. The rotavirus non-structural protein NSP3 is a sequence-specific RNA binding protein that binds the nonpolyadenylated 3' end of the rotavirus mRNAs. NSP3 also interacts with the translation initiation factor eIF4GI and competes with the poly(A) binding protein [3].	25.00	25.00	53.30	53.10	24.50	24.10	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.84	0.70	-5.45	6	508	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	241	10	0	389	0	266.80	87	89.08	CHANGED	EoTQthspSIlNuuF-AAlsussSsL-phGIpYDas-.VhuRl+sKachlhDDSGVpNNhIGKAtTIDQALssKhuSAtRNcNWhTsspTlARLDEDVN+LRhMLSuKGIDQKMRVLNuCFSVpR.PGKSSSII.......................pCT+LhK-KIERGE..lEV-Dphh-.+M-lDs...IDWKu+a-phcp+FpShtthV...........sEKYssWV.....hKA+KlsEsMhsLQ.sIupQQs+IsE...hphaNpKLp.+s..lps+.sShIuulEWhhpShph-D-l+sDhpQphNolsVINshpulD......DlE	.........ESTQQMVSSIINTSFEAAVVAATSTLELMGIQYDYNE.VFTRVKSKFDYVMDDSGVKNNLLGKAlTIDQALNGKFGSAIRNRNWMTDSKTVAKLDEDVNKLRMhLSSKGIDQKMRVLNACFSVKRIPGKSSSII.......................KCTRLMKDKIERGE..VEVDD.SaVDEKMEIDT...IDWKSRYDQLEKRFESLKQRV...........NEKYNoWV.....QKAKKVNENMYSLQNVISQQQNQIAD...LQQYCNKLE.sD..LQuKhSSLVSSVEWYLRSMELsDDVKsDIEQQLNSIDlINPINAIDDlE.............................	0	0	0	0
+4309	PF01452	Rota_NSP4		Rotavirus non structural protein	Bateman A	anon	Prodom_2202 (release 99.1)	Family	This protein has been called NSP4, NSP5, NS28, and NCVP5. The final steps in the assembly of rotavirus occur in the lumen of the endoplasmic reticulum (ER). Targeting of the immature inner capsid particle (ICP) to this compartment is mediated by the cytoplasmic tail of NSP4, located in the ER membrane.	25.00	25.00	98.70	98.50	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.11	0.71	-4.93	5	1516	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	459	20	0	1040	0	169.00	81	99.03	CHANGED	MEKLTDLNYTLuVITlMNsTL....HNIIp-PGMsYFPYIASVLTVLFThHKASlPTMKlAh+TSpCSYKVIKhVVVTIFNTLLRLuGYK-plToKDElEpQhsRIVKElRcQLcMIEKLTTREIEQVELLKRIYDhLhspsssEIDMSKETN+KsaKTLc-Wu.sKcPY-PT-VlA.s	......M-KLsDLNYTLSVITLMNDTL....HoIIpDPGMAYF...PYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKYCIVTIlNTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQVELLKRIHDpLIsRPlDhIDMoKEFNQKNlKTLDEWE.SGKNPYEPpEVTAS..	0	0	0	0
+4310	PF05087	Rota_VP2		Rotavirus VP2 protein	Moxon SJ	anon	Pfam-B_6280 (release 7.7)	Family	Rotavirus particles consist of three concentric proteinaceous capsid layers. The innermost capsid (core) is made of VP2. The genomic RNA and the two minor proteins VP1 and VP3 are encapsidated within this layer [1]. The N-terminus of rotavirus VP2 is necessary for the encapsidation of VP1 and VP3 [2].	25.00	25.00	63.80	63.70	17.90	17.40	hmmbuild  -o /dev/null HMM SEED	887	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.69	0.70	-13.64	0.70	-6.62	3	539	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	239	6	0	403	0	737.00	88	99.98	CHANGED	MAYRN...+RcpNopppDscpEK-sEpQ-..........-K-+pELKEKVhDKK-sVlTD..Ds.pDhK-psss-NLKlsDpVKcSpKE-SKQLlEVLKTKcEHcKEIQYEILQKTIPSFpPcEoILKKLcDIKP-.AKKpsKLFRLFEPKQLPIYRANGEKELRNRWYWKLKKDDLP-GDYDVREYFLsLYsQVL-EMPDYlLLKDMAVENKNSRDAGKVVDSETApICDsIFQDEETEGsVRRFIADMRQRVsAERNTVcYPAILHPIDYEFNcYFLpHQLIEPLTN-lIaNYIPERLRNDPNYILNMDsNLPoTARYIRPsLLQDRLNLHDNFESIWDTlT+ANYVLARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDAFKTIIAsMLSQRTISL-FVTSNYMSLISuMWLMTIVPo-MFIRESLVACQLAVINTIIYPAFGLQ+MHYpNGD.RRPFpIAEQQIsNFQVpNWLHFVNsNQFsQVVIDGVlNQsLNDsIRsG+IINQLMEALssLSRQsFsTYPlDYKRSVQRGILLLSNRlGQLVDLTRLlsYNYETLMACITMNMQpVQTLTTE+LQLTSVTSLCMLIGNsTVIPEPpTLFHYYsoNVNFHoNYNERINDAVAIIsAANRLDLYQKKMKuIVEDFLKRLHIFDVsKVPDDQMYRLRDRLRpLPVERRRlDVFsIILNNMDQIERASDKIAQGVIIAYR-MpL-YDEhYGaVNlARDlNGFQQINLEELMRTGDYuQITNhLLNNQPVALVGAIPFVTDSSVISLIAKlDATVFAQIVKpRKVDTLKPILFKINSDSNDFYLVsNYcWVPTSTTKVYKQVPQQFDFRsSMHMLoSNLTFTVYsDLLsFVsADTVEPINAVAFDNsRIMQEL	...................................MAYRKRGs+..REs...Q.Q..NERLQE.KElEps..sDs.M............p.psNN+.K.QQL.SDKVLSQKEEIITD..............sQDDlKIADEVKKSS.KEESKQLLEILKTKEDHQKElQYEILQKTIPTFEPKESILKKLEDI+PEQAKKQhKLFRIFEPRQLPIYRANGEKELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQILIEMPDYLLLKDMAVE..NKNSRDAGKVVDSETAsICDAIFQDEETEGslRRFIA-MRQpVQADRNlVNYPSILHPIDaAFNEYFLpHQLVEPLNN-IIFNYIPERIRNDVNYILNMDhNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDL..K..E..LVSTEAQIQKMSQDLQLEALTIQSETQFLsGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVlPNDMFlRESLVACpLAIlNTIVYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVAN.WLHFlNNNpFRQVVIDGVLNQsLNDNIRNGpVINQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLuYNYETLMACITMNMQHVQTLTTE+LQLTSVTSLCMLIGNsTVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKuIVEDFLKRLpIFDVsRVPDDQMYRLRDRLRLLPVEhRRLDIFNLILMNM-QIERASDKIAQGVIIAYRDMQLERDEMYGaVNIARNLDGaQQINLEELMRTGDYuQITNMLLNNQPVALVGALPFlTDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWlPTSTTKVYKQVPQ.FDFRsSMHMLTSNLTFTVYSDLLuFVSADTVEPINAlAFDNMRIMNEL...	0	0	0	0
+4311	PF00639	Rotamase		PPIC-type PPIASE domain	Bateman A	anon	Prosite	Domain	Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-10.28	0.72	-3.25	87	5141	2012-10-02 13:30:10	2003-04-07 12:59:11	16	48	2764	71	1422	7342	3338	93.40	30	34.16	CHANGED	HILltst..................tp.tts....cppupplhpplpsGt.....s.FsplApphS.Dsso...uppGGcLG..h...hsts.......phssp.Fpcslhshp...Gp.lS.tPl.....co..phGaHllcltc	.................................................................................................HILlp....................................t.tts.......cpphpplh....ppl...psGt........................s.Fuc.lA+..pa..S....-...s.s.S........up..p..G.....G-......LG......h...........h.p..s.......................ph.s..st....F....c.....c....s.....l..h.s..hp........h.....Gp.....lo..sP..l...............+o....p.h.G..aHllcl..t..............................................................	0	466	906	1210
+4312	PF03428	RP-C		Replication protein C N-terminal domain	Finn RD, Bateman A	anon	Pfam-B_4463 (release 6.6)	Domain	Replication protein C is involved in the early stages of viral DNA replication.	22.90	22.90	23.00	23.60	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.85	0.71	-4.82	52	484	2012-10-04 14:01:12	2003-04-07 12:59:11	8	4	191	0	102	471	13	159.10	41	44.88	CHANGED	RshThuhltuQhtuppht.ssts.lsKWclaRplscA+shlGlsDRuLAVLsALLSFaPcscL..spcssLlVFPSNtQLuhRApGMusuTLRRHLAsLV-AGLIhR+DSPNGKRYAR+spsGplppAaGFDLuPLluRApElpphAppltA-+pth+th+EclTltRRDltKLIpsuh-E	..............................................t.ht.t..st...t........tt..ssKWplhc.lsc.A+shlGls.cRuLsVLsALLoFaPcs..pl.......s............tp.s...........s..l...l.......VFPSNtQLuhRspGhussTLRRHLAhLV-AGLIhR+D.SPNGKRYARRs..p.s.GpltpAFGFsLuPLlsRut....E.lcthAppltsc+tth+phREplTlhRRDItKLIphuh...........................	0	12	46	66
+4313	PF03055	RPE65		Retinal pigment epithelial membrane protein	Griffiths-Jones SR	anon	Pfam-B_947 (release 6.4)	Family	This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein.  The  family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.	17.40	17.40	17.90	18.30	16.40	17.30	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.91	0.70	-5.94	151	2113	2009-09-10 15:57:50	2003-04-07 12:59:11	10	23	714	11	903	1992	868	396.50	24	89.26	CHANGED	pusassstpEh.sst....thpVp.GpIPspL.sGshhRNG..Ps.h...............ts....hthpHhFDGDGMlpuhpht.......sG...c....sp.apsRalcTptaptEp..psu...c.hlh.u.ht..............................sshps.............................hpssANTsllha...sG..............................+lLAh.hEsu.hPapl-s....toL-TlGh...hs.hs........................stlt.............tshoAHP+hD.PtTG-......lhsFuh......p..s.t.....tshlphhpl........sssG.............t.hhtp.hsh.shs..t..sshhHDFulTcsYslhhp..Plp...hs..thh...hut.......................................pshtacsppssp.htllsR...c....st..........ptl...............phacs.sss.asaHhhNAa....E..t.ts..............cllh-ssph...ssss.hh.............................................tt...t.hp......................tupLtRaplshp...s...............................................................................s.......ps.pp....phls.....pt...sEFPpl...........s.sphsGpp.hRasY.....................................shpsps......................hsulsKh............Dh....ps.......................sp....tp................................haphs.....spasuEPlFVP....ps..............su..........t......tEDDGallshVhct...pp............t...pSp..LlllDAp..shsp..sl..Acl.pLPt.+l..PhGhHGsalss	.........................................................................................................................................................................................tp.............h..l.t..Gp.lP............t.l.pG..hhRsG..s.s.h................................th.HhF......D....G.tu..............hlpthphp..........................................sG.......p.sp..atsRalpopt.hhttt...t.s.........hh.t.ht.........................................................................ht...sssNsslhhh.......ss..............................................chhuh...Ess.....ht...lp...........tsLpThuh..........hs..hp..............................................................s.lt...................shsAHP+.h....D..s....sGp.............................hhshsh.....s...................................shhphhhh......s.ps..................................t..hh.p..h.h....h...t...ssh.hHs....au.l..Tcpa..hl.h.p...slhh.p...thh......ts.............................................ht..ap.....ph...sp.hh....lls+......t...........st.........h............................................th...hcs.......sh....hh.hHhh.........NAa.....E.....ctt..................................pl.lh...hsth...ts.....h...........................................................................................................s.lhchhlsht....s............................................................................................s.......th..pt.....p.lt...........pt...shE.hspl........s....ph..hGp.p.h+asY........................................hht..................................sslh.Kh...............Dh...........s................tp........hp..........................................................ha..s.....s.th...suEPhFVP...ps....................................................su.......t.......tEDDG..hlls.hlhst.......tp...................t..p.u..lhll..DAp.....sh.......pt............lAph..pl..P...pl..PhGh..HGhah..t................................................................................	0	234	534	747
+4314	PF02318	FYVE_2	RPH3A_effector; RPH3A_effect_N;	FYVE-type zinc finger	Mian N, Bateman A, Eberhardt R	anon	Jackhmmer:Q13875	Family	This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A [1] and regulating synaptic membrane exocytosis protein 2 [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.06	0.71	-4.20	21	739	2012-10-03 17:27:21	2003-04-07 12:59:11	11	21	94	8	344	696	0	106.60	29	14.78	CHANGED	SpLTD-EAcHVhpVlQRDhcLRKKEE-RLucLKp+lpcEso++plLusptphs-opCl+ChpPFpFLlNoK..RQClDCchhlCKs.Cupa........sKpEpGWlCcsCphuRll.KhtSLEWaYcsV	..............................................LpctEtchl.pVltRs.phc.phEp.......c.......R..l..t..c.Lpp..c.l.......E.p.h.+.+...th..h............u...p...........t..........p.................s......p...p.....p.........Ch....hCtp...........h....s..hl.hsss........p.CpsCphplC.pp..Cssh............................pppcthWlCslCpc.p..ppl.hhtoGtWFap.......................	0	57	84	185
+4315	PF04390	LptE	DUF532; RplB;	Lipopolysaccharide-assembly	Kerrison ND	anon	COG2980	Family	LptE (formerly known as RplB) is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported from its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptD appears to be anchored in the outer membrane, and LptE forms a complex with it. This part of the machinery complex is involved in the assembly of lipopolysaccharide in the outer leaflet of the outer membrane [1].	23.30	23.30	23.40	23.60	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.01	0.71	-4.48	162	2176	2009-11-10 14:17:04	2003-04-07 12:59:11	7	3	2150	4	501	1407	1106	153.80	20	84.72	CHANGED	hhhhslhlu...uC...Gap.hssh.sh...................shthpslhlpss......pst..s.lpptlpcpLttsssthhsst...............hhLplphp.shsppshshs...tsu......ps..scaplshslpaplt...phsss.....phl......shs...sppsas..hs........ss..sl......upptpcpt..hhcchtpphAppllpclst	................................................h.hhhslllu....uC.....G.a+hpsss.th.........................s.phps.hhlsss...........cs.......s.lsctl....cppL...p....ts.s.sphlspp.pt.................spLclttsshsppshol.......psG....................ps...sEa..plhhslshplh......hssp......chh..........sho........sh+sa......s.............sp....sl..........Aps..sp....pch.....lh..p.ch.tccsucQllppl....................................................	0	147	308	412
+4317	PF04032	Rpr2	DUF363; 	RNAse P Rpr2/Rpp21/SNM1 subunit domain	Kerrison ND, Finn RD, Mistry J, Wood V	anon	COG2023	Family	This family contains a ribonuclease P subunit of humans and yeast.  Other members of the family include the probable archaeal homologues. This family includes SNM1 [2].  It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing.  SNM1 is an RNA binding protein that binds the MRP RNA specifically [2]. This subunit possibly binds the precursor tRNA [1].	22.60	22.60	22.70	22.70	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.31	0.72	-4.11	86	508	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	375	5	347	512	76	95.70	24	51.13	CHANGED	p.RlpaLhphAp............................................................................hst.sspl...u+pYlphhcplup+tplc.ls.p..h...KRphC+cCpshLlPGhssclRlp............................................................psh...llh......pChpCup	...................................................................................................................RlpaLhphAp............................................................................h....t.t..ts.s...pl....uchYsphhcplu..p....+tpl...+...ls.p........h...K.Rp....hC+..pCsshLlPGh.s.s.p.l+lc.............................................................................................................t..tph.......lsh........pChpCs......................................................................	0	97	190	288
+4318	PF01765	RRF		Ribosome recycling factor	Bashton M, Bateman A	anon	Pfam-B_949 (release 4.2)	Domain	The ribosome recycling factor (RRF / ribosome release factor) dissociates the ribosome from the mRNA after termination of translation, and is  essential bacterial growth [1]. Thus ribosomes are "recycled" and ready for another round of protein synthesis.	22.80	22.80	23.00	25.70	21.70	22.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.75	0.71	-4.78	133	4805	2009-09-17 04:39:55	2003-04-07 12:59:11	14	8	4668	22	1216	2907	2488	163.70	46	86.18	CHANGED	shcp-lsplRT.GRAssulLDslpV-hY...G.s.s....PLsplAslols-sRplhIpPaD.pshlpsIE+AIhs.u....sL.GlsP.p.sDG...phIRlslPsLTEERR+-llKts+.chuEcuK......lulRNlRRDu.cpl.Kchpcpt...loED-h+chpcclQKlTDcalpclDchhppKEKElh	........................................hcccluplRo...G.R.As.s.ulLDtlpV-Y..Y..................G..ssT...........PLsQlAslo..l...s..-uRsLhIs........PaD..+.............o..hltslEKAIhs.S.DL..GlNP....s..s-G..................slIRlslPs.L...TEER.RK-Ls...K.l+.phuEpAK..........VAlRNlRR.DApDpl.KK..hpKct-..IoED-h+c..tp.c.-lQKlTDphlcclDphlssKEpElh...................................	0	421	787	1030
+4319	PF00076	RRM_1	rrm; 	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Eddy SR, Birney E	anon	Published_alignment 	Domain	The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.  The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.06	0.72	-4.34	79	50512	2012-10-02 20:46:34	2003-04-07 12:59:11	17	788	1401	465	29915	55800	1095	67.70	24	23.75	CHANGED	laVssL..s.ssoccpLcphFpp.aGtl.hshplhtc.....ptpscGauFVpFpspcsAppAlpthsu.pplpu+plp	.................................................laVss.L........s..............p.....s.....s........c....p........p..........L......c........p......h....F.........p........p....a...........G..........p.............l.....t...........p..............s..........c................l............h............p...........c...................s.............s........p...........s............+...........G...............a...............u........F.......V...........p.......F........p...........s........t.......p.......s.......A...p..p.......A....l..p..t...h..ss..t.l.tsp.h................................................	0	9087	14852	22632
+4320	PF00398	RrnaAD		Ribosomal RNA adenine dimethylase	Finn RD	anon	Prosite	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.48	0.70	-5.36	20	6621	2012-10-10 17:06:42	2003-04-07 12:59:11	15	22	4983	44	1737	10162	4608	241.80	28	87.89	CHANGED	tsct+pphGQNFLpsppllpcIlcpsslp......pspsVlElGsGpGtlTptL.schs..cpVsulElDs+LschLpccht....psslpl.lppDhhpashPp........................p.atlsuNlPY.sIoosIlcpllp.......ttph..psshlllppphA++hhut.s..hhspLolhhpshs-hphltclspp..................................hFcPsPpVDS...ullclcR+spshh.s.tshppacshlcphhstcspsLtsslpphhstpphpthhc...tlspsshlsthshsphhshaphhsp	.................................................................h....pKphGQ.N.FLh.D...p..l...l..........p...p.I.l.p.sh..s..hp..................ps.s..s..l.lEI..GP...GhGu...L..T.p...L....hc..p.s............pp...lh....u...l.....E....l..D....p.......c.......L.....h.......s..h..L...p...c.pht...................h..s..p.....l...p..l...l..p...t...D....s...L...c...h..s..h...sp.......................................................................................................................tt.h...p..l.l...u...N.L......P......Y....p.....I..o....o..P....l..l.h..+l.lp...............................th......h.p.s...h.hlM...h.Q+..E.V......u..cR..l..s..A...t.P..s...s......+..t.Yup.Lolhh.p.h.h.s............p.s.ph.lh.pVs.p....................................................................sFhPs...P.pV-S..................ull...+..........lh.........+.....t.............p...................................................s.........p.........s.......p.h.h.......................p.....ls...ptsFs..p.RRKs.....l....tss...L.......t.......t.......h.....h.....s.....t.....t...........h.....t.....t.....................................t......lt.....p.......p..t..thh........t.....................................................................................................................................................	0	583	1087	1443
+4321	PF04353	Rsd_AlgQ		Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ	Mifsud W	anon	COG3160	Family	This family includes bacterial transcriptional regulators that are thought to act through an interaction with the conserved region 4 of the sigma(70) subunit of RNA polymerase. The Pseudomonas aeruginosa homologue, AlgQ, positively regulates virulence gene expression and is associated with the mucoid phenotype observed in Pseudomonas aeruginosa isolates from cystic fibrosis patients.	28.00	28.00	29.50	56.20	27.60	27.30	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.85	0.71	-4.51	45	788	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	784	1	95	305	19	150.50	57	94.34	CHANGED	MLpphcpApE+WGGspclID+WLppRQpLlVpYspLsultsh....tsspphss.pplpsFCphLVDYlSuGHFEIY-plhpcscthupp.uhclApplaP+IptoT-ssLsFND+Ysp.tpts..pltslsp-LSpLGEhLEpRF-LEDpLIchLass	....................MLNQL-NLTERVtGSNKLVDRWLcsRKHLLVAYasLVGIKPu....KEuahpLNEKALDcFCQsLV.DYLSAGHFsIYERIl+KlEGsG....pLscAuKIaPpLEsNTQpIMDaaDsslE.sAIDcDNhLEFQQsLSDIGEALEARFsLEDKLIhLl....t...	0	13	31	65
+4322	PF03873	RseA_C		Anti sigma-E protein RseA, C-terminal domain	Finn RD	anon	DOMO:DM07070;	Domain	Sigma-E is important for the induction of proteins  involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and  preventing transcription from heat-shock promoters [1]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal  periplasmic stress.	21.50	21.50	21.80	21.90	20.60	18.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.61	0.72	-4.08	40	851	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	844	4	108	351	9	55.60	58	26.46	CHANGED	sphPVLpTlPhsGsusPVSh.........stst.......ppssspp.QlpcQc+RIsAh..LQ-apLQpRL	................PEoPVFN..TLPhM.G.KASPVSL..........GVPSt....ssssu...pQp..QV.QEQRRRINAM..LQDYELQRRL........	0	10	33	73
+4323	PF03872	RseA_N		Anti sigma-E protein RseA, N-terminal domain	Finn RD	anon	DOMO:DM07070;	Domain	Sigma-E is important for the induction of proteins  involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and  preventing transcription from heat-shock promoters [1]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal  periplasmic stress.	23.20	23.20	23.20	23.20	22.70	23.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.01	0.72	-3.68	35	1145	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1114	6	217	651	141	93.30	42	44.32	CHANGED	Mtc..EpLSALMDGEts-p...pllptLspDp-hppoWpsYHLItDslRu-ss....tshphDluu+VusuL-sEPsh.s.............................ppPtPppsc+ts	...........Mt+..EpLSALMDGEslDs..............-LLs..tL..s..cs.s....E.hpc..TWcsYHLIRDsMRG-ss.........pslchDI.o..uRVhA...Al.EpEPs+ts.........................hhscuQPtPpphpp.............................................................................	0	35	97	162
+4324	PF04246	RseC_MucC		Positive regulator of sigma(E), RseC/MucC	Mifsud W	anon	COG3086	Family	This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions) [1]. In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium [2]. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain Pfam:PF02424, which is itself involved in thiamine biosynthesis. 	23.20	23.20	23.20	23.40	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.67	0.71	-4.59	118	1246	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1191	0	247	726	78	133.00	33	87.61	CHANGED	Vlslcss......hshVc.spppou..Cu.uCs.spsuCGtthlsphhss...ps.tphpl.......tsshshcsG-pVplulsEsslLpuuhllYllPLlsllhuuhluphlhts........-hhshlsulhuhshuahhs+hh...scphtp......p.thpPh..llph.h	............................VluhpsG....pAhVp.s.phcuu..Cu..oCu..u+.....suCGothlschssp........ps..pplhl........sssp.sLtsGpcVElGlsEs.oLLp.SAhLVYhhPLluLhlsAsLh.phLhss..........-lhulhuu.llGshsGFlls+th...u+.+.hst......cspaQPllLpl.h............................	0	81	160	208
+4325	PF03113	RSV_NS2		Respiratory synctial virus non-structural protein NS2	Mifsud W	anon	Pfam-B_2717 (release 6.5)	Family	The molecular structure and function of the NS2 protein is not known. However, mutants lacking the NS2 grow at slower rates when compared to the wild-type. Nevertheless, NS2 is not essential for viral replication [1].	21.00	21.00	220.50	220.30	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.72	0.71	-4.17	2	45	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	12	0	0	37	1	123.40	90	100.00	CHANGED	MsTspsc.TsQRLhlsDM+PLSlET.IhSLT+-IITHpFIYLINHECIVRKLsEpQATFTFLVNYEMKLLHKVGSTKYp+YTEYNoKYGTFPMPIFINHsGFLECIGIKPT+pTPlIYKYDLNP	MsTTpssTTsQRLMITDMRPLSlETIITSLT+DIITH+FIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHsGFLECIGIKPTKHTPIIYKYDLNP	0	0	0	0
+4326	PF04479	RTA1		RTA1 like protein	Kerrison ND	anon	DOMO:DM04303;	Family	This family is comprised of fungal proteins with multiple transmembrane regions.  RTA1 (Swiss:P53047) is involved in resistance to 7-aminocholesterol [1], while RTM1 (Swiss:P40113) confers resistance to an an unknown toxic chemical in molasses [2].  These proteins may bind to the toxic substance, and thus prevent toxicity.  They are not thought to be involved in the efflux of xenobiotics [1].	20.60	20.60	21.00	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.42	0.70	-4.87	6	1213	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	150	0	974	1227	0	215.40	25	69.27	CHANGED	IPFlhGsIhEhVGalsRshSSpNsschssallQsVhLLIAPsLYAAoIYMlFu+llclhtscshhLhSu+FsTshFVsuDllShlLQAsGGGLhuss....sS....poTGSpLlhAGLhIQlhhauhFlIsphpFhaplttpshahcc..h............................stpW..hahNhsLhluohLIhlRSIVRlVEFlpGa-GaIIoHEaalYlFDulPMhLssllFlls.hhtNlFchpscs.slp.	................................................hhhG..sh...hEhlGahuRhh.s.....t.....p...s.......s.........s....h...s......s.......a.l.h...Q.h..lhlllA...P.s........h...h.....s.....Aul............YhhLuRll.h..h.....h.....s........s..p.....t.....t............h..l.....p.....sph.hohlFlss.Dl.luhl..lQu....s..G.....G..u.l..h..u..s..u....................ss............hp..h....G...pplh.luG..LslQ.l..hh.h...sh...Fh.hh..s..h.h.........Fh..hR....h..t....p.......t........t...h...t....t.h.t.......................................................................hth.......th...h....hh.s.....L......hh.....us..hh.........I..hl..............Rs.......l.a.R....lsE..........h.......s..........t...........G............h....s.............u.......h.............l......hp............c...............E.hhh.hlhDuhhhhlshhhhsh....h...................hhh..........................................	1	179	455	813
+4327	PF02334	RTP		Replication terminator protein	Mian N, Bateman A	anon	Pfam-B_12997 (release 5.2)	Domain	The bacterial replication terminator protein (RTP) plays a role in  the termination of DNA replication by impeding replication fork movement. Two RTP dimers bind to the two inverted repeat regions at the termination site.	21.00	21.00	21.00	23.20	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.72	0.71	-4.15	3	54	2012-10-04 14:01:12	2003-04-07 12:59:11	11	1	52	17	14	37	0	119.40	66	98.83	CHANGED	MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSEFKpIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQLKVELDRCKKLIEKALSDNF	........................EKRosoGFLlKQRAFLKLYhIT.MTEQERLYGLKLL-lLRpEFKshG..a+PNHoEVYRuLHELl-D.GIL...KQlK.sK.K..EGsKhQEVVLYpF.pD...h..Et..AKLYKKQLKsELDRCttLIcKAlpDNF.............................................	0	1	7	8
+4328	PF02382	RTX		RTX N-terminal domain	Mian N, Bateman A	anon	Pfam-B_833 (release 5.2)	Family	The RTX family of bacterial toxins are a group of cytolysins and cytotoxins. This Pfam family represents the N-terminal domain which is found in association with a glycine-rich repeat domain and  hemolysinCabind Pfam:PF00353.	19.50	19.50	20.70	21.90	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	653	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-13.02	0.70	-6.26	8	309	2009-09-11 00:38:24	2003-04-07 12:59:11	10	16	156	0	5	280	2	490.10	49	61.72	CHANGED	pLsplKsplppshpsststL+pAupssKpuLppAupul+suGKKLILYIPKs..Y-utpGNGLpDLVKAA--LGIEVpR-ERNshAlAppshGTscKlLGLTERGlsLFAPQLDKLLQKppKlusslGSou.slupNLuKApTVLSulQShLGosLuGMcLDELL+spp..Gt..Sph-LAKAGlELsNpLV-NIASussTVDuFoEQlspLGohLpNsKuLGulGsKLpNLP..sLupsGhGLDllSGlLSulSAuhlLuNKcAsTuTKAAAGhELoNQVlGNIsKAVSpYILAQRlAAGLSTTGPsAuLIASsVuLAISPLSFLuIADKFcRAKpLEuYSERFKKLGY-GDuLLApFa+ETGsIDASlTTINTsLuAISuGVuAAuAGSLVGAPIuLLVSuITGlISGIL-hSKQAMFEHVAsKlusKIsEWEKKHG.KNYFENGYDARHtAFLEDsh+lLsshNKEapsERlVuITQQ+WDspIGELAGITRpGDKlpSGKAYVDaFEEGKhLcpcsccFsphlhDPtcGpIDlSso..ppoohLpFlTPLLTPGcEpRERpQoGKYEYITcLhVpGhDsWsVsGVtspsulYDaTNLIQ+s......sssssch+Es+IIucLG-GsDpVFlGSGSoplpAG-GHDsVaYsKsDsGtLTIDuT	............................................................................................................................................pthtphhppus.thKpsh.tuupthppuup+LhLhIPcs..Ycs.pGsulp-LlKAA--LGIcl.hp-tsshthspp.h.sssppllGhT-RGlsl.APQLDpLLQKh.....KluptlGuss.slspplsKstolLSslQshhG.sLuGhsLDpLlpp....t..op.-lAKuul-LhNpLVsslus.spol-uFupQlspLGuhlpsh.tLuulGsKLQNLs..sLs.hu.GL-hlSGlLSuhoAuhhLustsApT.upKsAAGhElsspllGNlsKAlSpYIlA...QR.hA.tG..LSoTu..ssAuLIsSsV.LAISPLuFhshADcFp+ActlcpYucRFKKhsY-GDtLLAtah.+poGsIDAulTsIsTsLuuluuGlu.AAusuSLlGAPluhLVuulTGhISsIL-hSKQAMFEHVApKhts+Is.EWEKp.s...KNYFEpGYDARH...A.L..pDshphL.phs+phtsERslhITQQpWDp.IG-LAuIo+p.u-+..SGKuYlshhcpGthlctp....p...hDs.pG.....IDlSss.....th.o.phlhFhTPhhTPGpE.RERhQoGK.EYhTpL.lpth.DpWplp..tstpushDhopllQhh.......t.ps.ph.ph+l.upLGstsD.Va.uuu.........os.l.uGpGaDhV.Ys+.sphGhLslDup.............	1	1	2	5
+4329	PF00016	RuBisCO_large		Ribulose bisphosphate carboxylase large chain, catalytic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	The C-terminal domain of RuBisCO large chain is the catalytic domain adopting a TIM barrel fold.	20.50	20.50	20.50	20.50	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-11.91	0.70	-5.58	16	53466	2009-01-15 18:05:59	2003-04-07 12:59:11	15	20	33109	329	419	47715	394	226.70	77	64.51	CHANGED	GItVER-+Ls...KYGRPlLGsTlKPKLGLSuKNYGRAVYEsL+GGLDFhKDDENlNSQPFMRWR-RFLaVhEAlp+ApAETGElKGHYLNVTAsTsEEMacRAEaAKE.lGssIIMhDhlsGGaTAssohApWsRcNs..hlLHlHRAhHuslsR.Q+pHGIpFRVlsKhhRhuGuDHlHsGTV.VGKLEGDtthshGFhchLRpshlppDtucGlFFcQDWuuh.ulhPVASGGIHsh+MPuLlchhG.DDsVLQFGGGTlGHP.GssuGAsANRVALEAhVtARNEGR-hs+E..Gs-llRcAAKhss-LpsAh-lW	................................................GIQVERDKLN...KYGRPLLGCTI.KPKLGLSAKNYG.RA.VYECLR.G........GLDFTKD........D.......ENV...N.SQP.F..MR.WRDRF....L.F.sA.EAlaKuQA.E...TGEI.KGHYLNsTAuT.hEEMhcRA...a.A+E.LG..s..sI.lM.h.D.alsG.GaTA.ssolA.hasRcNs....hL...L..H..l..H.RAhHush....s..R.Q+N.HGh.p.F.R.V.l.s.K.hh.Rh.S.GsDHlHu....GTV.VGK.L.EG-...hshGFh.DhLh-sal.-h.s.hs.p...G.laF..s.Q.D..Ws.....S..h..tV.hPVASGGIHshpM.t.Lh-hhG..DDsVLQ.FGGGTlGHP.G.tsGAsANRVAlEuh......h.u........................................................................................................................................	0	102	241	333
+4330	PF02788	RuBisCO_large_N		Ribulose bisphosphate carboxylase large chain, N-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain of RuBisCO large chain adopts a  ferredoxin-like fold.	20.70	15.00	20.70	15.00	20.60	14.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.59	0.71	-4.44	16	48498	2009-01-15 18:05:59	2003-04-07 12:59:11	11	16	32360	297	249	42335	208	118.10	84	32.42	CHANGED	+hsYasP-YssKDTDlLAsFRlTPQsGVsP.EAAAAVAAESSTG.TWTsVWTDLLTshDhY+u+uYcl-PVPGpssQaaAaIAYPlDLFE....EG..SlsNlhTSIlGNVFGFKAl+ALRLEDhRlPhAYlK	...........................................................................+LTYYTP-Yc.T.K.DTDILAAFRV........TPQ..P..GV..P.PE.EAGAAVAAESST.G.TWT..TV..W..T..D.G.L.T.S........LD.RYKGRC...YcI.....E.........P.....V.......s...............G.........E......E..............s...QY....I.....AY.V....AYP.LDLFE............EG....SVTNMFT.SIVGN.VF.GFKALRALRLEDLRIPsAYsK..........................	0	62	146	202
+4331	PF00101	RuBisCO_small		Ribulose bisphosphate carboxylase, small chain	Sonnhammer ELL	anon	Swissprot	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.15	0.72	-4.16	48	1831	2009-01-15 18:05:59	2003-04-07 12:59:11	15	17	903	230	280	1682	177	80.90	41	69.50	CHANGED	phpThSaLPsLospplt+QlcYllspGWssslEaspspphh..................spYWpMWpLPhFsspDsupVltElppC+psaPstYlRlluFDsh+..pspslSFIlpRPs	......................h..tshSaLPsLo..-.-QItKQ..lpYhlspGWssslEascc..t..h.................................................spYWphathPh..hs.pp.ttlh.plttshtt..st.t.al+h.uhDs................................................	0	88	203	253
+4332	PF02915	Rubrerythrin		Rubrerythrin	Griffiths-Jones SR	anon	Structural domain	Domain	This domain has a ferritin-like fold.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.69	0.71	-3.85	38	3551	2012-10-01 21:25:29	2003-04-07 12:59:11	12	31	1616	63	1303	4084	1248	115.30	23	56.86	CHANGED	-hLttAhsuEpsupthYpthAcphcpcs...lAclFpthAcsEpcHAthlh+hhpch..sh..s.....hhp.pht.hh..............slctshpsshhpEctuY.hYhcltcchtppptpch......hcphspsEptHtchactLh	.................................Lhtu...hsuE.p.p.u.h.p.hY.....t...hh...A...c...t..Ac..c....-..s....tlu...pl.Fp.phAppE.p.pH..Ap..hh..h..c..h....h...p..p...h............................................................................................h.t..................sl..t..t....h..h...t...s...t...h.t.....p...p.....hh......a...h...p....h...u...c...p..........s........t...t...h...t..th................hpthsp..E.ttHtphh.th.h............................................................................	0	520	931	1151
+4333	PF01330	RuvA_N	RuvA; 	RuvA N terminal domain	Bateman A, Finn RD	anon	Sarah Teichmann	Domain	The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts [1].	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.72	0.72	-4.18	33	4290	2012-10-03 20:18:03	2003-04-07 12:59:11	16	6	4259	26	913	2706	793	61.10	36	30.56	CHANGED	MIshl+Gplsclstshlll-ss.GlGYpltsstsphhphspst..psplasphllREDu....htLYG	....................MIuhl+G.h...l....h.ch.....p...s.....s.....h.....ll..l-ss....GVGYclpss........sshh...pl.......ts........t.....csplaTahlV....REDu..hhLYG...............	0	307	609	779
+4334	PF02075	RuvC		Crossover junction endodeoxyribonuclease RuvC	Mian N, Bateman A	anon	IPR002176	Domain	\N	21.50	21.50	21.50	21.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.86	0.71	-4.38	9	3205	2012-10-03 01:22:09	2003-04-07 12:59:11	12	4	3142	4	812	2187	1059	147.50	43	83.83	CHANGED	IlGIDPGochsGYulIcp.suppLphlssGsIRTsos.sLspRLhslh-ulppllcpapPshhAIEplFhupNssSslKLAQARGslhLAAspctlsVtEYsPppVKpAVsGpGpAsKpQVphMVp+lLsLsscPpP..tDAADALAlAIsH	.....................................................ILGIDPG.phsGaGlI..............c.......t......p......G....p.......p.........l.....p...h...lus.....G.s..I....+T........s...s....s..............s..l...s..pRLp......tIasulsclls.p............a.....p.....P.....DhhAI..Ep.l...F....h.s............+......N.....s.s.o...sL.K.LGQARGsAll.A....us.p..ps..L.P......Vh.EY.ssppVKpu..VsGhG.pA-K....pQVp.tMVp.p.....lL.pLs.s..t..P.p..........sDAADALAlAIsH....................................................................................	0	280	550	699
+4335	PF02042	RWP-RK		RWP-RK domain	Bateman A, Schauser L	anon	Pfam-B_9740 (Release 5.1)	Family	This domain is named RWP-RK after a conserved motif at the C terminus of the presumed domain. The domain is found in algal minus dominance proteins as well as plant proteins involved in nitrogen-controlled development [1].	21.90	21.90	21.90	23.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.58	0.72	-4.14	23	430	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	55	0	303	406	6	51.00	45	9.02	CHANGED	pppplohcplppYFphPlpcAA+pLs...........VssTsLK+hCRchGIsRWPaRKl+SL	..................h..tslolpsLpp..YFp.hslc-AA..+.p.LG..............................V.s.sTsLKRl...C...R........phG.I.sRWPpRKlppl.....	0	101	213	273
+4336	PF01365	RYDR_ITPR		RIH domain	Bateman A	anon	Ponting CP (EMBL alignments)	Family	The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels.  This region is found in the ryanodine receptor Swiss:P21817 and the inositol-1,4,5- trisphosphate receptor Swiss:Q14571. This domain may form a binding site for IP3 [1].	20.70	20.70	21.30	21.40	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.31	0.70	-5.10	18	1311	2009-09-11 08:33:13	2003-04-07 12:59:11	16	91	139	8	659	1057	8	191.60	27	11.19	CHANGED	tVhplLp-Lltahsssppctp...p.....c..hh+sh+p+QcLhRp.ulhphVhcllptsascp............hs-ppcttap................clhpLsachLpthppGsRpNQthhtcphs........h.th.hs.G.l.h-slpslLhsN.cLhptlpEtt.lcphluLlc+pG..RcschLDhLpslssusspslcssQ..-hIphpllssGc......DlLlphpl+sshsph	..........................................................................ht.LpcLlhhhhs.ppph.......t...p.........+....sh.+p+Qp.LhRp.shh.p..h.Vhcl..l.p...tsht..tp...........................tpp.pp..t..tap..............................................................................clhp.hsa.chL.p.th...........p...........p.....s.s.RpNQ.t...hht..c..p..ls........................h.....t..hs.G........h...h-......s.........h...ps...llhsN.cLh.p.t.l..p...-t.....t..lc...p....h.Vs....hl...cppG.................Rp.sp.......hL.chLpsl.s.s.s.p..s..p..slcssQ....-hlp.pll.s..s.uc......................-lLlphplhts....h.....................................	0	187	233	423
+4337	PF02026	RyR		RyR domain	Bateman A	anon	[1]	Family	This domain is called RyR for Ryanodine receptor [1]. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.	27.40	27.40	28.10	27.70	27.10	27.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.17	0.72	-3.96	38	1192	2009-01-15 18:05:59	2003-04-07 12:59:11	11	75	161	22	593	969	18	92.00	37	8.15	CHANGED	sasPpPlDhoslsLspcLp..................pls-+hAENhH-lWApc+l................ptGWpYG.....scss+pHPpLVPYspLsEpEKchsRphupEslKslluhGaslppsc.c	..............................................................tapPpPlDhop..lt.Ls.c.Lc...........ths-+lAENhHslWAtc+l................ptGWpYG....hp.....Dc.s..s..+pHPhLVPYspLs-......c........EKphsRp.spEslK.sLl.uhGaplphs.p..................	0	108	161	353
+4338	PF00575	S1		S1 RNA binding domain	Bateman A	anon	[1]	Domain	The S1 domain occurs in a wide range of RNA associated proteins.  It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.15	0.72	-3.89	51	46862	2012-10-03 20:18:03	2003-04-07 12:59:11	18	199	5058	118	11675	32137	17037	74.50	26	20.26	CHANGED	phphGsllpGpVpslsp..hGhhV-ls...shcGhl.hSplstp............hh.psspshphGcclclpllcl-pppppl.LSh+	...........................t..phGpll..p.G.p.Vp..p.lss.......hGs.F.V...........-.....l........s................s.........h...........-.......G.l......l........+..l.Scl.s.p........................................................hht.p..s...p.......c...h...l...p........h.G.c.cl....c..VpV...l...c.l....-..t....p..p.c...plsLoh..................................................................	0	3844	7387	9758
+4339	PF00438	S-AdoMet_synt_N	S-AdoMet_synt; 	S-adenosylmethionine synthetase, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	21.30	21.30	22.70	21.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.31	0.72	-3.78	115	5500	2009-01-15 18:05:59	2003-04-07 12:59:11	15	15	4837	44	1389	3870	2374	99.60	55	25.69	CHANGED	ppaLFTSESVoEGHPDKlsDQISDAlLDAhLppD..................Ppu.......RVACEThloTuhVlluGEl............oop...AhlDh...pclsRcsl+-IGYsp....sp.hGFDhcos.sVhsslcpQSs	............t.phLFTSESVoEGHP.DKluDQISDAlLDA.lLppD..................Pp...u..........RVACET.......hVp....TG..hVlVsGEI......................TTs.......AaVD...l...pcllRcTl+-IGYsp........u.c...hGFDuco...C.uVlsuIscQSP..................................	0	486	899	1177
+4340	PF02772	S-AdoMet_synt_M	S-AdoMet_syntD2; 	S-adenosylmethionine synthetase, central domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	21.00	21.00	21.10	22.20	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.56	0.71	-4.17	192	5503	2009-01-15 18:05:59	2003-04-07 12:59:11	11	14	4862	44	1376	3875	2680	120.30	51	30.99	CHANGED	c...p.GAGDQGlMFGYAssETspLMPhPIhlAH+Lsc+LuclR..K..sG.t...l..........saLRPDuKoQVTlcY....s.........s..+..P.....l+.lcol.VlSoQH.sssls.................cpl+cslhcpVIcsll.Pt..t....h.lcs..c.TcaalNPTG+F	....................p.GAGDQGlMFGYAssE.Ts.......pL.......MPhPIsLAH+....LscRlu-lR..K.....sG...p....L.......................saLRPDuKoQVTlcY....-s........................s.+...P..l+lDTV..VlSTQH...s..t.-.l.s.........................pc.p.l.ccslhEcl...I.+sVl....Ps....p..............h..L..cc.....p...T...+aaINPTGRF...............................................	2	473	885	1162
+4341	PF02773	S-AdoMet_synt_C	S-AdoMet_syntD3; 	S-adenosylmethionine synthetase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	25.00	25.00	25.00	25.00	23.80	21.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.85	0.71	-4.44	11	5527	2009-01-15 18:05:59	2003-04-07 12:59:11	11	14	4855	44	1384	3894	2871	137.30	65	35.56	CHANGED	IGGPpGDAGLTGRKIIVDTYGGauuHGGGAFSGKD.oKVDRSAAYAARaVAKSlVAAGLs+RC.VQlSYAIGVAEPLSIhV-TaGTuc..hopccLlcllRcNFDLRPGsIlKpLDLt+P...IYppTAuYGHFGRpc..FPWE+	.................IGG.PtGD.uGLTGRKIIVD..TYG.Gh..u.+HGGGAFSGKDPo.KVDRSAAYAARYVAKNlVA..AG.LAc+CElQl.............uYAI.GVAc...PlSlhV.-TFG.T........u...+........l.s..-.pp..l....h...c.h...V....+...c..hF.DLRPtuII....c...hLDL.......t.+.P.........IYppTAAYGHFGR..p..c.......hs..WEp.......................	0	483	898	1172
+4342	PF02574	S-methyl_trans		Homocysteine S-methyltransferase	Bashton M, Bateman A	anon	COGs	Family	This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases  also known EC:2.1.1.13, [2]; Betaine--homocysteine S-methyltransferase  (vitamin B12 dependent), EC:2.1.1.5, [3]; and Homocysteine  S-methyltransferase, EC:2.1.1.10, [1].	21.20	21.20	21.20	21.20	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.88	0.70	-5.12	16	4674	2009-09-12 00:27:11	2003-04-07 12:59:11	11	22	3246	24	1463	4033	4093	288.50	31	39.11	CHANGED	llllDGuMGTpLpspshshsc.hhphh..................ss.s..s.ppP-llpplHcsYhcAGA-llpTsTapuo.........hhuhu-hslscts.pplsptusclARtst-phs......psc............hhVsGulGPhsthhs...sschsu.hsssh-..slhchap.phcsLh-uG.sDlLhhETl.shtps+Ahlphlcp.hhpt.uh.shslh.ussl.-uoshppsushhcuhh..h..sphshlGlNCshsspphp.hhphhsp.......sthlhsaPN..uG.s.sss....htastpssphsp......slccaspsGu....plIGGCCGToPcHIptlucslps	.....................................................................llllDGuMG.Th.l.p.....p......h....s...l...s.....t...t..s.h.hht..........................................s.s.-.h..h.s.l.opP-...l..lp..pl.H.p.sY....l........c......AG.A.....D.........l.....l.........p.T.........NT..F..sus.............................hh.s.h..u.c.......a.......s...h...p...p.......h....s...........t-.l....s.tt...usclA.+psscch............................sscp................taVAGslGP.hs...s.....ss.p.s.u.h.t...s..l...oh........-..........plh.pta.p.cphcu.L......l.....-......u.........G.....s.....Dl......l......llE....T...h...Dhhp.s.+A.u....l.....h..ul...c......p...............h...............c.......t.........................s....h................p............hs.......l.........h........s..s....s...l..h.-...u.s..u.....h.p.h.u.u..p..s..h....pu..............h...h...........................p..s.....h..s....l......G..l..NCuh...G...sp...t..h.p.t.h...l...p..t.l.uph...................s..pthl.....s....s....aPN........A..G..L.P..p..ths................pYs..t..........s......s...p...p....hu....p..............hh.p.ca.h.....p..t.Gh..............sll..GGCCGTTPpHI..p..slscslt.s..............................................................	0	500	891	1214
+4343	PF04689	S1FA		DNA binding protein S1FA	Kerrison ND	anon	DOMO:DM04705;	Family	S1FA is a DNA-binding protein found in plants that specifically  recognises the negative promoter element S1F [1].	20.50	20.50	21.10	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.53	0.72	-4.10	4	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	20	0	27	40	0	66.70	66	44.78	CHANGED	tsssthEu.KGLNPGLIVLLVlGGhLLsFLVGNalLYsYAQKNLPPRKKKPVSKKKMKREKLKQGVssPGE	.....p....tEs.KGLNPGhIVLLVVuuhLLlFhVGNYsLYhYAQKTLPP+KKKPVSKKKhK+E+LKQGVSAPGE.......	1	6	16	20
+4344	PF05116	S6PP		Sucrose-6F-phosphate phosphohydrolase	Moxon SJ	anon	Pfam-B_6442 (release 7.7)	Family	This family consists of Sucrose-6F-phosphate phosphohydrolase proteins found in plants and cyanobacteria. Sucrose-6(F)-phosphate phosphohydrolase catalyses the final step in the pathway of sucrose biosynthesis [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.42	0.70	-5.08	23	845	2012-10-03 04:19:28	2003-04-07 12:59:11	8	21	568	13	267	12656	492	232.40	21	49.05	CHANGED	sphllVoDLDpThl........u-stuLtchpslhc..thcp-shLlauTGRo.sshpcLhcEhsL.pPDhllsSVGTEIhY..Gp.shhPDpuWpphLsp.cWs+..phVhchhuchPp.L.phQs-p-QpsaKlSaal-ppsu.shlppLpphLccpsLcl+lI.....aSsGpsLDlLPtsAuKGpALpYLtp+aphs...sppoLVCGDSGNDtpLF.lssshGVhVuN.uppE...hl..htEss+sp.plaaAppcsAuGIl-ultHasl	...............................................................................................................................................................................s..hhlh.DhDtThh.......................tp..........t...h.....h..t..h..t....t....h.hp............t...pt...phhhshsTG....pshp.phh....p....h....h.....p........p..h....s.....h..................p.....P......c..h.......h..........l..ss....l..G.......o.c.lhh.....................hp.....p......h.......h..............s.....p.....s.....a......p......p..........h.......l..............s...................p.......t......a....th.............p...tl......p..............c.....h.......l............t....p.................h............s..........p............l.....h................Q......................p...................t.................p...........p.....s.......t.....................a.....................+.......h.......s...................a......h.........h...c....p.....p...t...t........t....p................................l...c.t......l........p...p..h...h......p..t...p...s....l....p...s...p...h.h.................................h.....p...s......u.....h.....c.....l...D..ll.....P.h.sA.u.Ksp.A.l.p.a.L.h...p.+..a...sls.............hpp...h...l..s..h...GDS....G....N.D...h.p...hL..t.....sh.......t....pu..h.ll..uN...spt-....................................................................................................................................................................................................................	0	83	184	233
+4345	PF01023	S_100	S_100_domain; 	S-100/ICaBP type calcium binding domain	Finn RD, Bateman A	anon	Pfam-B_242 (release 3.0)	Domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	20.30	20.30	20.30	21.00	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.88	0.72	-4.63	24	1006	2012-10-02 16:17:27	2003-04-07 12:59:11	14	21	63	279	499	923	2	43.00	37	14.75	CHANGED	LEculpslIslFHpYSs+cGctpsLsKpELKpLlp+ELssaLcp	........LEpultslIssFHcY.usc-..G..c.p..tp.LoKpELKpL.lppELsshlp........	0	28	46	114
+4346	PF05124	S_layer_C		S-layer like family, C-terminal region 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	22.50	22.50	22.60	22.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.51	0.70	-4.72	21	129	2009-01-15 18:05:59	2003-04-07 12:59:11	7	18	45	0	79	134	6	166.90	23	29.97	CHANGED	psluussGaAplhIssslKsl-LG-EalsDaEhhsllpss.......sslchp-s..................hts...pplGlALpYsGDclpslccscphc.lusYA.ph.hDD-sp.s.cLpsaFphc....EpK-lolshGpclp...Vhsu-lhhp...tts..sh.hssPlshLDoEh...uL-su-psLILVGGPVVNplTcELsss..GtlsI..........-spSsATlsllcssAN..GscVLVVAGGDRtuTcpAApALlphl	........................................................................................................................................................................................................................................................................................................................................................................................................................s..ph.................s...p.hs..pslILlGGPVuNtlscp.ltsp....h.lpl.............................................s.sps.u...s.lt..h......l.......c.......sshN......sps.VlllAGu.DR.uTcsAsphh..........................	0	8	16	59
+4347	PF05123	S_layer_N		S-layer like family, N-terminal region 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	25.00	25.00	30.00	28.90	24.70	22.20	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.82	0.70	-4.78	18	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	36	0	27	57	1	268.00	29	44.88	CHANGED	KKIGAIAVGuAMluouLuouuh.AspclG-VssFh...sshVK.sGpPNVcIVVGSsA.AAhDVVSAAsIAAKIGSLhYpEssVE..DuSAslshsssu-S--lsl....h...sth.hhussspthlhsuuDsDY..........s.shsssshsshshsuhspsc....ssssLtD...........................LssLhplpDlDPssa...............hs.sDhD.AsEhlhsplsss.......h.ssotshplscDpllYsols..................apsshsuh..tshpsLp.....GhcIPaLGcEhslVclDpD.........DDhlhlGpcsY-Gslcp.G-saslGsGYpVcl	..............................KKIuAlAlGuAMluusLusush.Ahpp.l.uslss.....s.hVp.sGpPNVcIVVGSsA.AAhDVVSAAsIAAKIGSLhYpEtslc..ssusslphpspsc.o-sh.l.....................hss.sstthh.hs..ssss.sY.................s.t...s...ss..hs.....sh..htshsphs.....thhslt-..............................................................................................................ls...shhplpch..DPpsa...............hs.pD.-...us...Ehlhshlpss.................stphpltccphhYholh.....................hpss...ts.....t.htslt..............Gh..plshLGpchhllplsts.........schlhlGp.sapGhlcp.G-shslGsGYplcl...................................................................................................................................................................................................................................................................................................	0	3	6	16
+4348	PF00954	S_locus_glycop		S-locus glycoprotein family	Finn RD, Bateman A, Mistry J, Guo X	anon	Pfam-B_357 (release 3.0)	Family	In Brassicaceae, self-incompatible plants have a self/non-self  recognition system.  This is sporophytically controlled by  multiple alleles at a single locus (S). S-locus glycoproteins, as well as S-receptor kinases, are in linkage with the S-alleles [1].	21.80	21.80	21.90	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.31	0.72	-10.95	0.72	-3.78	52	2074	2009-09-12 20:30:07	2003-04-07 12:59:11	15	105	84	0	900	2114	0	104.00	27	16.50	CHANGED	aRSGPWN..GhRFoGlP..-hp.thsh..hshsFs.....psspElsaoaphs.sssh.hSRlhlossGhlpphsW.ssspsWsh.hattPtc.pCDhYthCGsauhC...sssssPh..CsClpGFhPcs	...........................................................................s.Wt..t..h...........................................h.....h.shs..........pspp.Ehh.as..a..p.h.t.....s...s......s..h......h.s.R.l..sl...s.....s........G....p...l.p.hhs...W..........t.....s...s...p.......p...W.s........h.....h...a...p.....t...P..p.......c...pCD.h......Y......s......hC.Gs.a..u..hC.............s..h..s....s.........s....P.h.....Cs..Cl.p.GFpP.........................	0	43	507	728
+4349	PF00526	Dicty_CTDC	S_mold_repeat; 	Dictyostelium (slime mold) repeat	Finn RD	anon	Pfam-B_96 (release 1.0)	Repeat	\N	21.30	21.30	21.80	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.84	0.72	-7.18	0.72	-4.07	30	447	2009-01-15 18:05:59	2003-04-07 12:59:11	13	20	8	0	381	438	10	23.70	56	31.53	CHANGED	NsCThDoCsspsG..CsHTPlsCDDs	.NsCThDSCsss..s.G..CsHTPIs.CDDt......	0	300	381	381
+4350	PF00277	SAA	SAA_proteins; 	Serum amyloid A protein	Finn RD	anon	Prosite	Family	\N	21.10	21.10	21.20	21.30	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.41	0.72	-3.67	18	208	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	68	0	67	243	0	98.00	63	73.11	CHANGED	WapFhtEAsQGAtDMWRAYpDMREANa+sSDKYFHARGNYDAApRGPGGsWAA+VIScuREshQuhh.........GRGtEDotADQcANcWGRSGtDPN+........YRPpGLPcKY	.......................hpFltEAhpGAtDMWRAYs.DMREANYpsuDKYFH.ARGNYDAApRGP...G.Gs....W....A...AcVI........SDAREshQphh......................G+GtEDShADQtANcWGRS.GpDP.N+...............aRPtGLPpKY.....................	0	12	14	23
+4351	PF04455	Saccharop_dh_N		LOR/SDH bifunctional enzyme conserved region 	Waterfield DI, Finn RD	anon	COG1915	Family	Lysine-oxoglutarate reductase/Saccharopine dehydrogenase (LOR/SDH) is a bifunctional enzyme.  This conserved region is commonly found immediately  N-terminal to Saccharop_dh (Pfam:PF03435) in eukaryotes [1,2].	22.10	22.10	22.10	24.60	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.10	0.72	-3.90	35	168	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	154	4	103	180	22	102.10	34	17.28	CHANGED	hhs.Rp..lELcGHllDShlls+slDpIh-hGGsFcllcFslG+p+sDsSaAclpVpAcspcpL-pILspLpplGAs..s-....p-scLtsuspDtVhP-sFY..oTTNas	...................................h..scplcLcGHLlDohlls+sLDhIh.-hGGsFcl.lchc......l......G.pp.....+.p........ssS.aAclp.VsAsspphL-cIlspLpslGAs....-........p-spht...ss.tstVhPcsFYsoT.h..................................	0	34	78	97
+4352	PF04092	SAG		SRS domain	Bateman A	anon	Pfam-B_1675 (release 7.3)	Family	Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. SAG1 is composed of two disulphide linked SRS domains. These have 6 cysteines that form 1-6,2-5 and 3-4 pairings. The structure of the immunodominant SAG1 antigen reveals a homodimeric configuration [2]. The SRS domain is found in a single copy in the SAG2 proteins. This family of surface antigens are found in other apicomplexans.	20.80	20.80	20.80	20.80	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.94	0.71	-3.74	58	921	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	7	14	768	924	0	131.00	20	67.81	CHANGED	sssssoC..............sssssssplslopp.ssolTlpCussss....hhPs..shsp......................ptCs....t.ttssp.hslpslL..ssssps..Whpt......spsspstsL.slspsshPtss.psFhlGCptpsss.....................sttssCpVpVsV	..........................s...hssC......................ts.ss..sshpl.slopp.psslolpCsssss.......hhPs..shsp.........................phCp...............t.t...ss...s..p.t..h.sl.s..s...l.l.....ssssps......hhpp..................sssssshsL...sls.sshP.t.ps..p..p..h..hhu....Cttssss......................................................................tttssCpVpVsV........................	0	325	325	768
+4353	PF01259	SAICAR_synt		SAICAR synthetase	Finn RD, Bateman A	anon	Pfam-B_1426 (release 3.0)	Family	Also known as Phosphoribosylaminoimidazole-succinocarboxamide  synthase.	19.70	19.70	20.70	21.10	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.54	0.70	-5.28	11	4852	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	4550	22	1252	3379	2876	240.90	34	87.99	CHANGED	ph.llsc.....GKs+-IYcl-D..spLLhlspDclSAaDslhcspIstKGplhsphSpFhFphLp.h.lssHhlct.s......................-.sshls+KhchlPlEsVVRsYlTG....ShhKc...sGsh..cGlclsssllEs.hhs-slhsPphpsE...Hs.slu........hsps..hlG.-pssplcchshplaphhcchhtppGlIlsDhKhEFGlDp-s.cllLsDEl..PDSSRhWsssshc....h......hDKQhhRchLsssspuhp.ts....hsphspsl	..........................................................p.thlYc...GKsKclY..........p...........s..............s.........c............shl.l.hh.hpDcho.........A........as...s.h......hp.......p.......p.....l....s.sKGtlsNplosahFctLp.....c.........h....sl........s.....o...Hhlcths.........................................................s...pphl.l..+...+...l......c............h...............l..P..lEsVlR.shh.s.G....ShhK+....h..G.hc........pG....h..tLs.p.slhEh......hh.K.....s..........D.........sltDPhhssp..........Hspsls.........................................hss..t....................................-.p...l.s...pl...+...chs......h......cl....p....hlpchh..t.ptG.....lhLlDhKlEFG....h..........s......p.....s..G.......c......l.lLuDElu.PDosRh..WDtcshc......p..............hD.K-haRp.....Ls.s.h..h.tsap..thh.+l....hh.....................................................	1	399	785	1040
+4354	PF03534	SpvB	Sal_SpvB; 	Salmonella virulence plasmid 65kDa B protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.00	20.00	20.20	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.82	0.70	-5.39	17	349	2009-01-15 18:05:59	2003-04-07 12:59:11	8	62	230	0	113	340	33	223.30	27	12.78	CHANGED	LussGssGhAolSlPLPlSsGRG...huPsLuLsYsSuuGNGsFGlGWphslhsIsR+Ts+GlPpYssp.....DpalGPsGEVLlssh.sspGp.phcpt.pthtshshstsaoVoRYpsRlEupFsRlEaWpPpsssss............sFWllassDGplHlhG+sspARlusPp....ss.s+lApWLLEESVo.ssGEHIhYpYcsEDcsss-tschpsp............stoAQRYLppVpYGNhpsutsLashss....s.Pssp..p.........WLFpLVFDYGERssshpssPtaps..........stsWhsRpDsFScacYGFElRTRRLCRQVLMFHph	...................................s.s.GtA.o.holPlslssG.R.u...hsPsLuLsYsSs....u.........G.......N....G......................hGlGWsl.u.s.....u.I.p......R..........c....T.p.......t........s..lP.p...Yssp........-t.h...h.h.suc.hl........stt.st..................tp..................................................tth..t.s.....t..pa.sc.hp.s.t..Ft+lphht..sts..sstt.............aWhlhstsG.hthhG...t.....s......s....su.+.l.....ssst......................t.....tphhpWhl.p.cshs...stGpt.lhYpYttp...s.t.....................................................................................................................................................................................................................................................................................................................................	1	46	73	97
+4355	PF03538	VRP1	Sal_vir_VRP1; 	Salmonella virulence plasmid 28.1kDa A protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.80	21.80	21.80	22.50	21.20	21.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.12	0.70	-5.38	4	244	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	119	0	42	182	1	201.10	21	19.16	CHANGED	sppsSPLL........S+ltstaplsstlhcp..............GYpSlFDIlRhsRcpFIccapt..us+utt.haDhAsuhApQlhppFRpppL................o+tV+tshhpsaSs.s.......PpYts.F.-s...WpphsPssusEussSPVuYLhclYphs.p.E.susspul.slsERRsDLusLhlsscuINppIssLplVNphLSpthpthlp.ps.t..ss.thLupsRaP.pLPYcasppQIphuhsspcspLtcIhppsshsaP...W.......................................................................h.....LSsslssA.schsh...........................................................................................hAsphu.pQQplhsEsltssspp...FYQsNYGlss.sss.hctlshFspQTuloVs	...........................................................h..............................................................................................................................................................................................................................................................ushtYh..hh.......................................t.................h..thspRRPDLtpLhlsp..pshppplssL.h..phh..........................................................................s.h..hPYp.shp.lp....l...s..thtth...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	6	18	32
+4356	PF01758	SBF		Sodium Bile acid symporter family	Bashton M, Bateman A	anon	Pfam-B_697 (release 4.2)	Family	This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+ [2]. Also in the family is ARC3 from S. cerevisiae Swiss:Q06598 this is a putative transmembrane protein involved in resistance to arsenic compounds [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.22	0.71	-4.89	17	4441	2012-10-02 17:06:44	2003-04-07 12:59:11	11	12	2582	2	1463	5194	1717	184.60	24	56.02	CHANGED	slhLhlhMashhhplphcchtphhpc...sKhlhluLlhpallhPllhFllu.hhhthhst...................hhhGllllGssPssuhu.las.LucGchs.Lulshsshoo....htshhhsshhhhhlstt.h.ls........h.hhphhtolllhlhlPhhhGhls+hhh.......hh.phhh.hlsshulhullhslhlhhuhpuphlsph	..........................................................................................hLhlhMa.shhhp.lphpch.t.pl.h.cc.................s+...s.............l...h...l.u.l.l.h.pa...ll.hP.hh....h.a.h.L...u....h...h...h...t..h...st..............................................hhsG.l.I.L....l.G.s.sP.s.s.s.h.s.....V.a..........o.hL.uc..GDss..h...................ols.h.sul...so........lhshhhsP......lh...h....h....h...l...s...s.t...h..ls...........................h..h..s..h...hh..S.l..lhh.lll..P..lhhGhlh+.thh...............................h.h..t...p..p..h...h.s..h..l...ss..ho.l...l...ul.lhs.ls.lh.hu.hpsp.lh..t....................................................................................	0	485	921	1207
+4357	PF03536	VRP3	Sal_vir_VRP3; 	Salmonella virulence-associated 28kDa protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	40.50	33.00	19.10	21.30	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.68	0.70	-5.21	3	62	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	47	13	7	51	0	213.90	60	91.85	CHANGED	PINRPsLKLNLPSLNVVssSEtPQMsSTNE+LKNNFNSLHNQMRQMPsSHFKEALDVPDYSGMRQSGFFAMSQGFQLsNHGGDVFIHA+RENPQSKGDFAGDKFHISVtREQVPQAFQALSGLLFSEDSPIDKWKVTDMERVsQQSRVulGAQFTLYVKPDQENSQYSAShLHKTRQFIECLESRLSESGlhPGQYPESDVHPENWKYVSYRNELRSGRDGGEMQcQALREEPFYRLMsE	............................................................................................s.h..sssc..cLKsNFs.L.asQhRphPsoaFK.A.sVPsYSshpQSuFhsMtQG..FQ.lsNH....u.hDVFIHAcREsPQSpGcFAGDKFHISVhR-.VPpAFQALSGLLFSEDSPVDKWKVTDM.....p+Vs.....QQuRVulGAQFTLYlKPDQEsSQYSApaLHKhRQFIpCLEScLScsGVh.sG.ppP-SDV+PEsWKYlSYRNELRS......sRDGuEhQcQtLREEPFYRLMhE...............	0	2	3	5
+4358	PF01536	SAM_decarbox		Adenosylmethionine decarboxylase	Bashton M, Bateman A	anon	Pfam-B_600 (release 4.0)	Family	This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes.  In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine [1]. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.	21.20	21.20	21.30	21.40	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.20	0.70	-5.77	15	693	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	387	56	340	679	15	293.80	34	87.33	CHANGED	sSAhuFEGhEKRLEI.Fhcsthhs-spu+GLRuLs+uplDclLssAcCoIVSohuN-plDSYVLSESSLFVasaKIIlKTCGTT+LLhuIPsILcLAcslu...........hpVpuVpYoRtsFlFPssQsaPHRsFoEEVshLDuaFu....supAYlhGsscps.p+WalYoso.....sps.....pps...pPsaTLEMsMoGLD+-pASlFaKscu...............usAusMTppSGIc+ILPsSpIs........DFpF-PCGYSMNu..l-usshuTIHlTPEDGFSYASFEosh....hshcshslspllp+VLsCFcPscFSVsla....sssss+phpp.shsl-lc.uYshcctshpsls.hussllYtcFs+st	..............................................................s...hFEG.EKhLEl.F.................................................................t........t.......s.......t........s...........LR.s.ls....ttphcphLp.spCpIlS.hp.......s.......ct.......hDuYlL..S..ESShFVash..+.lllKTCGTTpLLhuls.l.....Lc.lAtths..........................................hp.ltplhYoRts.FhhPt.....t.Q..h.PH.csap-EVthLsthFs.............supAYhhG.p..sps....pW...alYsss....................................t................p........................ps.s.TLE.hhMo.tLD.p...hsp..F.ah.s.ps.....................................................................sputthoptoGlp..c..lh...Pt.s....t....l....s................................................sa.FpPCGYShN............u........h.................p......ss......th.TIHlTP..E...s....t....a..SYASFEss...............................p.t.h.s.h.sp.llp+VlthFp..PscFslsla.............t.t.t.t..........t................h...........................................................t...............................................................................................	1	100	180	271
+4359	PF02199	SapA	SAPA; 	Saposin A-type domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.30	20.30	20.50	20.40	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.07	0.72	-4.19	32	428	2009-01-15 18:05:59	2003-04-07 12:59:11	10	66	91	0	167	403	0	33.70	48	10.43	CHANGED	GpcpCshGPuaWCpshcsAppCs..AVpHCpppVWs	.......GhcpCshGPuaWCpshcTAspCs..AVcHCpppVWs......	0	47	59	101
+4360	PF03058	Sar8_2		Sar8.2 family	Mifsud W	anon	Pfam-B_2148 (release 6.4)	Family	Members of this family are found in Solanaceae plants, a taxonomic group (family) that includes pepper and tobacco plant species.  Synthesis of these proteins is induced by tobacco mosaic virus (TMV) and salicylic acid [1]; indeed they are thought to be involved in the development of systemic acquired resistance (SAR) after an initial hypersensitive response to microbial infection [1,2]. SAR is characterised by long-lasting resistance to infection by a wide range of pathogens, extending to plant tissues distant from the initial infection site [2].	27.10	27.10	27.20	27.90	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.40	0.72	-3.66	4	33	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	9	0	0	33	0	83.60	47	99.24	CHANGED	MFSKT.LFLChSLAILlhVISSQADAREM.SKAAAPITQAMNSNNIoD.QKoGAGllRtl.Ghhh+hspsh...................CKhCpCp.tlCshC..Ct	..Mh.KsNlF.LChSL.IlLhlISSQssAREM.ScAuA.slTpuMsuNNhTp.pKsG...uulh+plsshhppssp.ssp.....................hhGpsCKhCssph..C.h..........	0	0	0	0
+4361	PF04790	Sarcoglycan_1	sarcoglycan; 	Sarcoglycan complex subunit protein	Waterfield DI, Finn RD	anon	Pfam-B_6135 (release 7.5)	Family	The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle.\	  The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.  This family contains beta, gamma and delta members [1,2].	27.40	27.40	27.80	29.50	26.80	27.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.62	0.70	-5.22	16	335	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	85	0	193	287	0	224.50	34	82.30	CHANGED	laplGIaGWRK+ClYhhVLLLhllhVlNLsLTlWIlpVhpFs.cGMGsLclppc.Glpl.cGco-F..lpPlYspcIcuRpDpsLhlpS......spslolNs...RNtpGpls..s+lslusct..l.stsptFplpss.st+.LFosDpsphhht.tpLclssPpGu....lFt+uVpTstl+us.sspcL+LESsTRplshcAscGVplcAtAGtl-hpuppDlpLpSs.......cGplhL-A.pslhLs....+LPhups......ssGspps...hYclCVC.ssG+LFhussstsps....Cp	.............a.hGlhGh+ppshahhllLLhllhllNLhlTlh............IhtV.....hphs...sGhsphcl...ppp...G..........lhh...c.G.o-h......l..PL.atpplp...uR.spsLhlpS.......spslslpt...hs..Gph.........spL..ls.pt..s.spsptFplpss..stphLFosDtpph........h..phspGs..................lh.pslpTstlp....up..s.p-LplcSssR.lhhcuscGVplputs..lchpst........t-lpLp.S..............-GplhLsu...tslhls....pLPpus....................sst.tpt................haclCsC..ssGpLahs.ssstp.................................................................................................	0	42	56	118
+4362	PF03343	SART-1		SART-1 family	Mifsud W, Mistry J, Wood V	anon	Pfam-B_3690 (release 6.5)	Family	SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing [1][2].  It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae [3].  SART-1 is a known tumour antigen in a range of cancers recognised by T cells [1].	20.50	20.50	20.70	20.50	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	613	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.63	0.70	-13.46	0.70	-6.17	38	393	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	272	3	287	395	7	455.60	25	80.12	CHANGED	-uLSIEETNKlRhpLGLKPLslsss............................ssshcscputshcshpch........pcpscs++cc-ch..pppIpc...u+-ctp.pppKLts..psLu-t...........t-ss.DspuWlpcp+Kh..p+phpttctct.....................tpptpc+pps..spasspD...LsGlKVsHclcchpc..GcshlLTLKD.ssVL-s--t.....D.LpNlsLh-+c+tpcplch+K+p............p.sp...t.tppslLu.pYDE-lpsccpcp.........hph......cspupssct..................................pppccp......pspt+h+hphhsh-.....................spspp.sSDYhs.p-.lK..hKKsKK....................Kctpppp++phh......Dp.t..st..t..s.t.tttt...............cl-pps......................ss.hcpc.p.ps.shs...............DD-DL..QtpLsppR+hth+....c+pchcs.EclAcplcpppspsp........pcpp-.......................csulVls-TSEFlps..Lp........psshtcpttpp...................pcpspp.tsh.psppsptp.............tstssphpps.ss.pcc-........................t..tthssshl-cEsslspGLuusLphLKp+Gllc................ppppchhtppthhth..phptphpcct.c.tss+hsph....R-chh.chppcp+-ppc..............................tY+PcVcLcYlDEhGRphssKEAFKp.LSHpFHGKGsGKtKpEK+lKKlE-E+	.................................................................hSlE-sN+lRhpLGLpPl.h...........................................................t..t..t.p.h............................t.....pptpth...tttltt....+ptt..........htt..ttltc.....................sh..sWl.p.pph.....................................................ttt....ttts.........LtslpVtHthtph.p....ttp.lLTL+D....psl........pptp....................D..L.N.p......hhcppchpcpht.pppt......................t..........................t.....t.l.Lt...pYD-....p.ttpt.pt..............................tttt.h.....t..........................................................................................t.tt..t........t.tp.p..t..p.p.........................t.t.ss-h..hp...tc..h.p.....hKK.K..p.....................................+h...th.pp...................................................................................................t....................................................................................t..............................................--..t-h.....tt.Lttt+pht.h...........t........p...p.....tlh..p.lt.t.ttt.............................................................................tsslhhsthsEFsts.....lt...............t......t.....t...............................................tt..t....t.t.tt.............................t.thtt....p...tt.............................................................................................................h.ttE..hstGhuusLthhpp+uh.lp..........................................................ttt......t..ptp..h.........t.......t....p.pcppt....................................................................hpsplplpYhD-.G+.hs.KEAF+..LSHpFHGKssGK.K..hEK+h.K+hppc........................................................	0	101	164	247
+4363	PF00269	SASP		Small, acid-soluble spore proteins, alpha/beta type	Finn RD	anon	Prosite	Family	\N	20.60	20.60	20.70	20.70	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.84	0.72	-4.11	66	1862	2009-01-15 18:05:59	2003-04-07 12:59:11	15	3	421	3	380	1047	9	56.40	40	83.13	CHANGED	NchlVPp..AcpAL-ph................KhElApElG....V..thppt..G..-lTSRpsG.p....VGGpMVK+MlpttEppht	.....................................Nphhl.tAppul-ph....................KaElApEhG...........................V.p..s..s.....t.....sh.o..uRpsG.u........VGGph....sK...RhlphAEppl.t.......................	1	177	310	333
+4364	PF04259	SASP_gamma		Small, acid-soluble spore protein, gamma-type 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The SASP family is a family of small, glutamine and asparagine-rich  peptides that store amino acids in the spores of Bacillus subtilis  and related bacteria. 	25.00	25.00	26.00	25.80	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.66	0.72	-3.85	7	317	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	241	0	29	139	0	75.60	64	86.98	CHANGED	StTsAQpV+pQNtpSut............t.auTEFASETNsQpV+QQNtQSt.t.t.su.......utpspassEFASETssppV+pQNtpupApKppsS	..............K.ATSGASIQSTNAS...........YGTEFA.TETNVQAVKQANAQSEAKKAQASuA......QSANASYGTEFATETDVHuVKKQNApSAAKpSQSS...........	0	8	20	22
+4365	PF03898	TNV_CP	Satellite_CP; 	Satellite tobacco necrosis virus coat protein	Finn RD	anon	DOMO:DM04608;	Family	\N	27.20	27.20	28.60	306.80	21.10	27.10	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.30	0.71	-5.26	4	4	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	4	62	0	5	0	199.80	42	98.28	CHANGED	MoK+Qsppps....+psstpsV+sIlpsphEpKRFsLlsssNsssTAGTVhNLSNsIIQGDDIsQRoGDpI+hhpphL+sRsTuITsSQo..F.RFIWF+DNpNRGTTPuVTEVLsSAshhSQYNPlThQQ+RFTlLpD.VpLsCSlsGcsIKcpshshstp.tlaYNGAsuVAuSNGPGAlFhL.IGDplsG..paDluhEhhYhDh	MoK+Qsppps....+psstpsV+sIlpsphEpKRFsLlsssNsssTAGTVhNLSNsIIQGDDIsQRoGDpI+hhpphL+sRsTuITsSQo..F.RFIWF+DNpNRGTTPuVTEVLsSAshhSQYNPlThQQ+RFTlLpD.VpLsCSlsGcsIKcpshshstp.tlaYNGAsuVAuSNGPGAlFhL.IGDplsG..paDluhEhhYhDh	0	0	0	0
+4366	PF03110	SBP		SBP domain	Bateman A	anon	Pfam-B_737 (release 6.5)	Domain	SBP domains (for SQUAMOSA-pROMOTER BINDING PROTEIN) are found in plant proteins.  It is a sequence specific DNA-binding domain [1]. Members of family probably function as transcription factors involved in the control of early flower development [1]. The domain contains 10 conserved cysteine and histidine residues that probably are zinc ligands.	21.60	21.60	22.20	22.70	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.08	0.72	-3.76	30	552	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	54	3	340	562	0	72.80	55	16.94	CHANGED	pCQVEuCsuDLSsu.KpYHRRHKVCEhHoKushVl.luGlpQRFCQQCSRFH.LsEFDEuKRSCRRRLAGHNcRRRKsps-	.................................CQV-GC.psDL.oss.K.cYHRRHK....VCEhHu..K..ust.V...l.luGh....p..p..RF.......CQQCS.............RFH.LsEFD.p......s......KRSCR+RLss.HNc....RRRKst..t.....................	1	93	251	302
+4367	PF00496	SBP_bac_5		Bacterial extracellular solute-binding proteins, family 5 Middle	Finn RD, Yeats C	anon	PDBSum	Domain	The borders of this family are based on the PDBSum definitions of the domain edges for Swiss:P06202.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.29	0.70	-5.64	226	27055	2012-10-03 15:33:52	2003-04-07 12:59:11	17	39	4221	130	5660	20528	6027	361.60	19	67.34	CHANGED	plhPtLAcs....................p...hssDspsasFpLRcsl+apDG.s......slTAcDVha....o.....hcchhssssssthhhhh.................................................htplpsscshslplphppP.ss.........hhhhhsthstthh.....................................................................tttttsthtppslG..oGPaplpp...ap....sp...plh.lp+.......Nss..Y...W.......................t.sps....tlcplphphl......csssthtth.psGclphh..hths.....ssshtth....ttptthph........................tts...shthhhlthNhp.....................pt...sh.sc..........hplRpAlshAlD+c.tlscth...................h.tshstsstsh.hssshshhtt.ht.......................................................hs....pcA+pLLpcAGhpss.......................................hhhhhsssssstp.phuphlppplpp..lG.......lclplpsh.t.........................................thh........psshshhhh..sasss.hssstshht.hhtssstst	..................................................................................................................................................................................................h.PtlAcp.h.................................................................p...h.s..p.D..s......p...s...a...s...Fp..L..R....c..s.s.....+....a....p...s.....G..p...................................sloA.cD....l..ha........o.................h..p...+...h..h..s....p.s.ss..thhhhh.........................................................................................................................................................hhs.lc...s.h..D...s..t.T.l...p.lpLppP...s...................h..hhth..l..u........s.h.hhh.....................................................................................................................tt.t.t...t...t..t..p..h.s.p...p.s...l.G..........oG.P.a.p.lpp....................apt...sp......plt..hp.+................N.ss........Y.....W.....................................................t..tps................t.lc.p.lph.phh.................-s....ss...thtt...h...ps..Gp....h...p....hh.......t.h..s..............sp.p..h..t.p.h.............pp.s.tthph...............................................................ts....sh.shh....h..l..th.Nhp....................................................ps....sh...ss............hplR.pAls..h..ul..c..+.........p...tl......s.p.t.l....................................................h....t..s.....t....s...p.....s......s....t......sh......hs....s....s...h..h..t..h..s..s.t.ht...............................................................................hs......pcA....+....p....l.....L....p....c....A....G..hp....s.......................................................................................hhh.h.h......t.....s.....p.....s.....s.....t....p....p....hu.......ph.........lp...p.p....hpp.....lG...........l.p.l.p.l...psh...ph..................................................tthhpt....hp.p.t..p.a..c..h..hhh.....s.a...s..ss.......ss..thh..h.t......t.............................................................................................................................................................................................................	0	1562	3337	4515
+4368	PF03480	SBP_bac_7		Bacterial extracellular solute-binding protein, family 7	Bateman A	anon	Pfam-B_808 (release 7.0)	Family	This family of proteins is involved in binding extracellular solutes for transport across the bacterial cytoplasmic membrane. This family includes Swiss:P37735, a C4-dicarboxylate-binding protein [1] and the sialic acid-binding protein SiaP. The structure of the SiaP receptor has revealed an overall topology similar to ATP binding cassette ESR (extracytoplasmic solute receptors) proteins [2].  Upon binding of sialic acid, SiaP undergoes domain closure about a hinge region and kinking of an alpha-helix hinge component [2].	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.60	0.70	-5.30	35	6254	2012-10-03 15:33:52	2003-04-07 12:59:11	8	19	1778	54	1762	5551	7504	278.70	22	82.64	CHANGED	hupss.ussssptpus.phFschlpEc.osGcl..plplaP..supLus-t.phlctlpsGs......l-hshsusuhhssh.sPphtl..hsLPFlF.........pstptsc+.hhsuthu..cpLhpphcpp.GlpsL..ua.apNGh+phos.sp+PlpsP-Dh+G..LKlRl.tushhhphhctlGAsPpshsauElYpuLpsGslDGpENshssl.hst+haEVQKYhohos..Hsh...sshhllhspshassLst-hpphlccAspEus.phtpchhpctspphhppltc.....sGhplh.hos.cppsa.pcuhpslac...c.atcp	.............................................................................stsp.s.h.t.t.sh..pth.u.ch...l..p...c..t....osG.c.l..plc.l.as....supL..s.s..st...ph..h-..t..l..ps..Gs......l-.hs.h.s.s.s.s.h.h.s.sh..sP..t.hsl.......h..s..l..P.....a.l..h..........p.s..h...p.p.h..tp...h..h...s..u..t..hs...........ppl..h..p...p..h...pp....p....G...h..h.s..L.....uh...h..........s...s...G.h....c...p....h.....ts....t....p....+.....s.....l...p........s..s...s.....D.....l...+...G.....lK...l.R.s.......s....s.....h.h.hp..h....h.c.t.h....G.....A.....s.....P..ss.h..s.h.u.E.lYsALp.p.GslD.u.tE..s.s.h.s.sh..hshp.a..h.E..V..t..+..a.h.s.h..s.s.......ash......s.s..h.h.ll..hs..pp...h...a.ss...L..........s...s..........-............pphlpp.u..s....p.cus....p...h....t....p........p..h....h.............p....p....t.........p.p.....p..t................hp.......p.hpp.........tG.s..pl........h..s..p......p.h.p.sa....pc..s.s.p.s.h.hpp.....t.........................................................................	0	536	1184	1514
+4369	PF01297	TroA	Lipoprotein_4; SBP_bac_9;	Periplasmic solute binding protein family	Finn RD, Bateman A	anon	Pfam-B_1416 (release 3.0)	Family	This family includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum.	22.10	22.10	22.30	22.10	22.00	21.60	hmmbuild  --amino -o /dev/null --hand HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.47	0.70	-5.14	141	7592	2012-10-06 15:37:50	2003-04-07 12:59:11	12	12	3969	42	1428	5388	2851	272.40	24	83.10	CHANGED	Vlsoh.sltslscpl..uG..-.............t.spVpsll.ss.Gs-.PHsa..pssPpshpplpp...ADlllh..sG.hshE..s....a.lschh.........ttsphthl.......shsp........sl................................................................................phhtt..........................................................................................................ttttcpsp........................................................................................................................................................................................................DPH.lWhsPpsst.thspslsctLsch.......-Pppts...hYppNhppahpcLpplcpphpptls.sht.t........pphls.hHsuas..Yhscpa....GLp...huhh........thss..tpcsospcltplhctl+ppslpslFh-sphssc..hscpl...upcs.G..sp...l.......lhlcsl........................st......sYhphhpp....Nhpsltpul	........................................................................................................................Vlsohtsltshscpl......uG...-.................................p...splp....sl....l.ss....G.s-...s....HsY......cspsp....Dl...t.p....l.....pp...ADlll.a.sG..hshE.....s....a..hp+hh.................thp.ppp.hphl................tssc.....sl.......................................p..........................................................p...p.................................................................................................................................................................................................................................................................................................................................................................................................................................DPH..sWhssppuh..t.h.spsItct.L.sc.h.......DP.p.pps....t.Y.cpNhppahp.c.LppLcp.ph.pp...ph.s...sh.p........+th.l.s..pHs..Aas..Yhucpa................Glp......t..hshh..........slss...-pc....sospplpplh.ch.l..+.....c.p.....p..l.ps.....lFs...E.s..p.s.s.s..c.......sscsl.......uc.cs....u....sp...h............hhlssl....................ttt..t.tsp...sYhs.h.hcp.shpsltps..................................................................................................................	0	431	876	1187
+4370	PF04405	ScdA_N		Domain of Unknown function (DUF542)  	Yeats C	anon	Yeats C	Family	This domain is always found in conjunction with the HHE domain (Pfam:PF03794) at the  N-terminus.	28.90	28.90	29.00	30.50	28.30	28.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.56	0.72	-4.58	70	1136	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	1115	0	170	543	24	56.10	44	24.94	CHANGED	ts..pslG-lVsphspuuclFccasIDFCCGGptsLscAs.pcpsl-.stllpcLpslt	....+.spslGElshshP+A.oslFRpYclDaCCGGppoLtcAu.t++slDls.l.scLspL.t..........	0	52	104	142
+4371	PF02667	SCFA_trans		Short chain fatty acid transporter	Bashton M, Bateman A	anon	COG2031	Family	This family consists of two sequences annotated as short chain fatty acid transporters, however, there are no references giving details of experimental characterisation of this function.	20.00	20.00	20.10	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.63	0.70	-5.71	4	740	2012-10-02 15:12:49	2003-04-07 12:59:11	9	3	662	0	154	1076	192	418.50	44	98.19	CHANGED	hlpRlophhsthVSKaLPDPLIFAhLLThVTFllshsLTspssls.........lVshWGsGFWsLLuFuMQMALIlVTGpALAous.Vp+lL+plASlsKsshpulhLVTFhu.IAshINWGFGLVVGAhFA+....ElARplKGsDYsLLIAsAYhGF.lTWtGGhSGShPLLsATPspslp+lhst..s.pthIPlspTlFSuYNlhIhshlllshPFlhhMhhPKpuElhuIDs......KLltcEhc.pcpls..cDsTlA-+LEpS+lLuhlIuhLGhuYLGhYFacpGF...lolNsVNhhFlhsGlLLHtoPhAYMRAIspAARSsAGILVQFPFYAGI.hMMcaSu..lGG.....lIophFhsVANccTFPlhTFaSuulINhhlPSGGGcWsIQGPhllPAuQALGsDlGKosMAIAaG-tWhNMhQPFWALPALuIAGLGsRDIMGYClosLIFsullhslGLhhl	.......................................................................................................................................................................................ht+hsphhsphspRaLPDsal.FuhLLTllsh.l..hAh.hhs.s.psPh.p.........................hl.ph.WG......s...GFW...s..LLuFu.MQMALll..VTGasLAo.os..l++.lLp.p.h.A.p.hs..+ost.p.u.l.hh.Vo..hluhlush...l...NWGFGLVl..GAlhA+....El....A....R....+....l..c....s....s..D...Y.....LllAuAY.GF...lsWtu.G.lSuS.h......PLhhAT.s...G...p.......htchh....u....................lIPh.o-Tl..Fo.s..aslh..h.s..lsl..l.l.s..hP....h..ls.t.h..h....h.....P....c..s........p...c..s...l.s...l.Ds................pllt.c.....-s.s...h......p.....p..........h....s............................t......p..s...............s.P.uE.+LE.p.Sh.....l......L.......o...ll.l....u..h.L..G.l..s.Y.l..h..h....a..F.....p...p.G.hs.........l...s........L.N.........h.........V.....N...h..h...F....L.......h....h....G.l......L.......L......H.....t......T......P...h....s....Y.......hc.........A....ls....p...A....s...+.....o.s.u....G...I.......L.......lQF..P.F.Y.A.G...Ih.u.h..M.t.p.u.u....hs.G.................h......I...o....p..a...F....l..s.....l...A.....s.....c...c..T......F...P..l..h....s.....F..l.....S..u..u..l.l.NhFVPSGGGpWslQuPhllPAApsL.G....sc.........h.........u.........pssMAlAaG-uWsNhlQP...F....W..A..L..P..s..L..u..I.........A.........G..L...t....s....RD...I...M..Ga.....C....l....s...tL....l..hs.Ghlhslshhh...............................................	0	45	86	124
+4372	PF04486	SchA_CurD		SchA/CurD like domain	Kerrison ND, Bateman A	anon	DOMO:DM04327;	Domain	Members of this family have only been identified in species of the Streptomyces genus.  Two family members are known to be part of gene clusters involved in the synthesis of polyketide-based spore pigments, homologous to clusters involved in the synthesis of polyketide antibiotics.  The function of this protein is unknown, but it has been speculated to contain a NAD(P) binding site [1]. Many of these proteins contain two copies of this presumed domain.	24.20	24.20	24.40	45.70	24.00	24.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.21	0.71	-4.25	16	83	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	40	0	25	85	0	109.00	36	61.55	CHANGED	h.RHALoYsl+PGststlAclLu.........hps.sAssDsss.llpTolFh+-shVVRll-VcGDh.s.hhtahu.p..s.tsEpAlsPhLcpsRchu-scuhhshhtcAAhsslppsssts	....RHALoasV+PGstttlAclLA..........thps.pA..tsDssohLhpoolFh+sshVVRhl-Vc....GD.L.t.hhtahu.p..hpssEtAls.hL..cp..sRchucspuhhthatcAuhsslpphs..s................................	0	9	21	25
+4373	PF02630	SCO1-SenC		SCO1/SenC	Mian N, Bateman A	anon	COG1999	Family	This family is involved in  biogenesis of respiratory and  photosynthetic systems. SCO1 (Swiss:P23833) is required for a  post-translational step in the accumulation of subunits COXI and COXII of cytochrome c oxidase [1]. SenC (Swiss:Q52720) is required for optimal  cytochrome c oxidase activity and maximal induction of genes encoding the light-harvesting and reaction centre complexes of R. capsulatus [2].  	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.88	0.71	-4.65	6	2856	2012-10-03 14:45:55	2003-04-07 12:59:11	9	21	1787	30	1082	3642	2070	164.20	24	74.44	CHANGED	IuLllusGuthsaLh......LpTsKtspssph.....csplsGPFpLh-.pGc.Fsp-sLpGclSLlYFGFTpCPDICPstLc+lsshlcpLcpc.pIclQslFIolDPcRDTPcVLKcYlpsFcsuFlGLTGshcplKslsccaKVaasps.ssKssp-YhVsHSsFhYLIss-G+hlcta..shs	..............................................................hhhh................................................................................h....s...F....pL.h....s....p...s.G...p.......h...s.....p...s...h....c...G....+....h.hl...............l.a.FGa.TpC..P..D..l..CPs...p...lsp...h....s.ph...h..........c..........p..........l...sp............p......t.......t.......c...........l..p.sl....F....l....o..l...D....P..c......R.......D.....T....s.......p.h.L..p.......p....Y....s.....p...t...F.....s.....s.....p.....h.....h..u.....L...o...G....s..........p.........p.......l.....p...p.....h.....s.....c......p......a......p......l.....h.a....p.....p............s.......................................................................t......t................s...............Y.h....l...sH...........os......hhaLls...pGph.........th...................................................................	1	322	667	895
+4374	PF02036	SCP2		SCP-2 sterol transfer family	Bateman A	anon	Pfam-B_1050 (Release 5.1)	Family	This domain is involved in binding sterols. It is found in the SCP2 protein Swiss:P22307, as well as the C terminus of Swiss:P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Swiss:Q17372 contains an SPFH domain Pfam:PF01145 [2].  	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.11	0.72	-3.72	174	3603	2012-10-02 14:08:01	2003-04-07 12:59:11	12	54	1915	19	1132	2747	690	100.00	20	46.14	CHANGED	lsplhpt.......p..tttstlpplsu.......shphpl.psh.h.....shhlshp...ss.phpl........hst.t..psD..sslshsssshhplhsuc....sspphhhps+..LclcG.Dhtluhclpslhp	.............................................................................................psthptl.pu...............hlplcl..pshsh....................phhlshp........st..plpV................httht...tpsD..solps..s.ss..s.....Lht.lh..stc.......ss.ssh.hhps+..Lc.l.c.G.Dh.pluhplpslh............................	0	351	606	884
+4375	PF00375	SDF		Sodium:dicarboxylate symporter family	Finn RD	anon	Prosite	Family	\N	19.80	19.80	19.90	20.00	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.42	0.70	-5.71	135	10806	2009-01-15 18:05:59	2003-04-07 12:59:11	13	12	3666	24	2273	7267	1474	380.50	26	90.76	CHANGED	L...hhplll..ulllGlllGh......................................h..hsphsshlp.hhGslFlphlphlllPL.lhsollsuluslts..scplG...+luhpslhhahhooslAshlG.lhluhlhpPG..........................stts..........ssststpstpssshhp....hlhshlPsN.......hhtuhs........ps....................................................................slLslllFullhGlulstlsp..cs........cslh.phhcshpclhh+llphlht.luPlGlhulhAthsup.hG.....hshlh.sluthllsshluhhlhhhllhslhhhhhsph.sPhch.h+thhsshlhAFuTsSSsATLPlslcssccph..........G..VscplusFllPLGsTlNhsGo.ula.ulsslFl...AphhGls.lo.hsphlhlllssslsSlGsAGVPGuulls.lshlLs..slG...lP.....h.pu....luLllul-hll.DhhRTslNVs.GDsssuhlls+h	.............................................................................hhhplll.u.lllG.l.llGh......................................................................................................h.h..t.h..s..p..h..h.....p...lGsh.FlphlKMllhPl.lhs.ol.l.s..u...............lus......h.tp...........hpphG........+l.u.hh.sl.hh.a.h...h.s.ohl.AhhlG.ll.hu......lht.Pu....................................................................hh..ts.........................tt.s.s..h.s.s....t.s..p..s....s.l.hp........hl.h..s.h....l...P...s...N.......hhtuhs........ps............................................................................................................................................................................................................................................................................................................................................................................s.hlsl.lh..FulhhGlu....ltt....hspps....................pslh..phlpsh..sphhh.p.l.l.p.h.l.h................p...hAPlG.l..hulhutslup..hG...........hs.slh..sl.u.phlls.hh.hshll.h.hhll.hs.l.l.h.h...h.s..t.h..s.............sh.p.h...h+t.l...t...ps.hl.....hAas.T...pS.....S...tu...slPhshc...phcc..h......................................G..ls.csls...uhs.lPhGho.hNhsGs.ula.sh.sslhl.......Ap.s..h.........G..l..s...l....s....hsp....h.l.hl..l........l........lh.hl.sSh....G.............s.A.GVsG.........uuhls..lshsLs....shG.......lP..............h...ps.......lullhu....l-h.....lh..D.sRTs....lNlsGss.lsshllup...........................................................................	1	579	1152	1742
+4376	PF02982	Scytalone_dh	Scytalone_DH; 	Scytalone dehydratase	Griffiths-Jones SR	anon	Structural domain	Domain	Scytalone dehydratases are structurally related to the NTF2 family (see Pfam:PF02136).	20.20	20.20	20.30	20.40	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.20	0.71	-4.65	3	125	2012-10-03 02:27:23	2003-04-07 12:59:11	9	3	89	20	62	135	1	145.70	58	84.45	CHANGED	sITFcDYLGLpssLFEWADSYDSKDWDRLRKlIAPTLRIDYRSFLDKlWEAMPAEEFlAMISDKsVLGDPTLKTQHFIGGSRWEKVSDTEVIGHHQLRVPHQ+YTDoThpEVslKGHAHSsNhHWYRKVDGVWKFAGLKP-IRWuEYDFDcVFcDGR-Sa	......................sap-hhuhppssaEWADSYDoK..........DWDRLR+CIAPTL+.........lDYRSF.LsKh..W..EAMPA-EFlAMhSDssVLGNPLLKTQHFl.Gu.o+WE+lSDsEllGaHQLRVsHQ.+Y.......TDso.....hsp..VsV..K......GHAHShNpHaY+Kl-GlWKFAGltPtl.a.phph..............................................	0	7	26	50
+4377	PF03313	SDH_alpha		Serine dehydratase alpha chain	Bateman A	anon	Bateman A	Family	L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyses the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.	22.20	22.20	22.20	22.60	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.76	0.70	-5.37	152	6294	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	3519	0	918	3774	323	283.70	38	69.93	CHANGED	pcp.slsluphhhcNEhs.htssp.p.lttthsphhssMtssscpGL.....ps.pGlhsGslphh+chh.........................................................................................................................ph..tppL.t.................................tt.................................hthhshshhhAhAssEtNAuGGplVssPTsGu.....uGllPuVlhhh.cchph.................................................s-.-plhchLhsuuslGhllKpsAoluGAtsGCQuElGsAsuMAAAulstlhGGoscQlppAuphulpphLGLsCDPluGhVplPClcRNAhuAspAlsuAphA.hts.s.t..ptIshDcVlcoMtpsGpshssth+ETupGG......LAhs	....................................................................................................................................................................................t.p.shslutlhhpNEhs.ht....spp......c...lttthsphhpsM...p...s...sl...c+...Gh.........ps..c.G.lh.s.Gs.l.p.h.h.R+hh.......................................................................................................................................tl...pctL......................................................t..ht.p.c................................................................s...htshs.hlshaAlAVsE...p..N.Au.G.G..pl.VsuP..TsGu...........sGllPuVLhhh...c+at.h.....................................................sc...-phh.+aLhsA..u..AlGhlhK...pNASISGAEsGC.......QuE........VGsAsuMAAAGlstl.h.G.............G.o...............Pp..Q..l....s.AupluhcctLGLsCDPVuG.V.plPClcRNAhu.AspAlsAAcMA..lpt....s.st...stl..s.l.DcVIcoMhpsG+sMs.spa+ETucGGLAh.h.......................................................................................	0	290	558	751
+4378	PF03315	SDH_beta		Serine dehydratase beta chain	Bateman A	anon	Bateman A	Family	L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyses the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.	21.40	21.40	23.00	22.00	18.90	21.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.13	0.71	-4.17	190	5230	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	3484	3	788	3051	241	140.80	39	37.95	CHANGED	SlF.Dlap.IGIGPSSSHTsGPM+AAphFhpt.lt.............................p..........psp+lplpL..aGSLAhTG+GHuTDpAllhGLhGhpP-slchc.............th..hhtthttpt.l.h...............s......ptlpFs.p.pslhachcphh.s....hHs..Nuhphp..........Ah...sssthlhppsaYSlGGGFl......hs..p...pttst	..............SlF.Dlap.lsIGPSSSHTsGPM+AGptFhst.Lt...............................................p............pss+..lpl..cl..YGSLuhTG+GHsTDhAllhGLhG.pPpslclc..............h..hht.h.tptpl.h.......................tt.......cpl.pas..hp..p..s..l..h..a..c......p..p.l...s.......hH....NuMplp.............Ah.....tss..p.....h....l...hp.p...TaaSlGGG.FIhscc...t...........................................................	1	238	475	648
+4379	PF01127	Sdh_cyt		Succinate dehydrogenase/Fumarate reductase transmembrane subunit	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite & Structural domain	Family	This family includes a transmembrane protein from both the Succinate dehydrogenase and Fumarate reductase complexes.	25.20	25.20	25.30	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.95	0.71	-4.28	125	5134	2012-10-03 07:11:12	2003-04-07 12:59:11	17	5	2968	88	1395	3246	2736	114.00	19	77.37	CHANGED	hphp+P...........hs.ph......thhp.....p..hsshh.lhpRloGlsLhh.hhhhlhh........h.h.hhhht.sst.sasth.........tshhs..........hhhlh.hhhhhshhaHhhsGl+pllh..D...h.hh......pss........ttps.hhhl.shshhhhhhh	.................................h.........................ht..............ssh.t...l.hpRl.oGlllhl......hhhlhh................h.h.....hh...hs...sth...s...apth.................tshhss........h.hht.hhh..h.hhlhulhaHshsGlp..pllh.....D...h...h.........cst.............thph...hlhh...shslhlslh.s.......................................	0	374	831	1144
+4380	PF02810	SEC-C		SEC-C motif	Aravind L	anon	Aravind L	Family	The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the  CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.	20.40	20.40	20.60	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-6.81	0.72	-4.38	183	7596	2009-09-11 12:15:01	2003-04-07 12:59:11	10	82	3806	5	1631	5164	1418	20.10	67	3.86	CHANGED	RN-sCPCGSG+KYKcC.Cttht	.....RNDPCPCGSGKKYKpC.pGp..t.....	1	545	1051	1369
+4381	PF00995	Sec1		Sec1 family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_530 (release 3.0)	Family	\N	20.20	20.20	20.40	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	564	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-13.08	0.70	-5.88	150	2115	2009-01-15 18:05:59	2003-04-07 12:59:11	18	29	328	14	1402	2034	44	467.10	18	86.95	CHANGED	hKlLll..Dptstslluhshphs-Lhpps.Vslh...................tplcs..........................pR...............psh.shpslahlpPs.tcslctl.hp-...................lpp........................................spYppaalhFss..................shs..cshhcpLupss.............shptlpplp-....hhlcals...l-sslF.....oL.....p..hs.............................psa....tthhs..............................................................................................pttppslp....phupuLhsl.hhohsp...........hPhIRhpts....................................................hucpluptltphlpct.........p.htttpps.t.........................................sl..LlIlDRshDhloPLlppaTYQuhla-llslpp...splpl..........psst.ttp............................+.phhLss..pDthasphpttpasclsp...plpphlpcap..p.p..............................ppppttshs.clpphlpp.lPphp.cppsplshHhslssplhpplppcp...Ltc.hhclEQslss.ssststp.....hhp.lhch..l.............ssp.....h...-+LRLlllahlp.....t.t..spphpphpchlpps..t.hs.pph.....thlpplpphsthht..p.................................t..............t..pp.tht.h.......thhpth.pt..p........................ssp.hhsp.ap.......................Phlppll-sl...........................hpsph..sppashhssps.................................t.t...tt........................................................pph....pcllVFllGGsTYsEhpslt.plspptt.................................h.clllGuTsll...........ssppFlp.pl	.........................................................................................................................................................................KhLlh..Dp.........hht...ls...h.h..p.....ptlh.p.....t..l.h.h......................lpp.................................pp.....................t.h..ph.....slahl.p.......P....p...............ps.....l..phl..hpc.....................................................hpp..................................................................................hhpt.h..alh....Fss....................................hs..t......h..h...p.l....tptt...........................t.l..t.t.l...-............h.h.sa..hs....h-splh...sh...............p..................................s.h......th...................................................................................................t.t.t..lp.....thsptlhsl.....h.s.h.t....................hP.h.l..ph.tt.....................................................sp..hlsp..lt.p.h.hpp.....................h...p.p.......................................................................s....LlllDRshD.hoslhpp....hTYpuhhp-l......h...s....l....p......t......s..t...hph........ps...t.t.............................................................c.ph.Lst...pD.ha..p..tt.ph.spl..st...tlpp.hpphp....tp..............................................tptt.tsht....chpphl....pp.hPphp.p..tt...t..hs.h..Hh...slspt......h..ph.hp.....t.pt.................h......p...hhphE.....pplh....t.s........ptt.....................p.....h.ch.l..........................................................stt.h.s..stl.Rl.h.h.l.h.hh.......t....t.......t.ptht..p...l....ps...............hs.......pth..............hlpphtt..hsh.h.t...................................................................................tp..ht.....................t...tt..p...........................................t..p.........h..st..at.......................shltplhpph.....................................................hpt.t..........ppt.a..h.h..ps............................................................................................................................................................................................tpth.phllFhl...............GGsoh.tEh..tsh.h..hspt.t............................................hclllusoplhsspphlpt................................................................................	0	535	782	1152
+4382	PF03908	Sec20		Sec20	Wood V, Griffiths-Jones SR	anon	Pfam_B-21631 (7.2)	Family	Sec20 is a membrane glycoprotein associated with secretory pathway.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.89	0.72	-4.28	6	380	2012-10-01 21:14:52	2003-04-07 12:59:11	8	5	278	0	245	459	5	90.80	25	29.24	CHANGED	SpspplTcuLhshpphhspslppSs.slpsLssSTpsLpphs-capphpsllppo++LlKphp+p-psD+hllaluhuhFlhsVsYlVhKRI	.....................t..spplTp.uLtcspphhspplppS.p.shpsLp..........pSopslpphspcap.s......h.ss..............hlppu+pLlpphtRpphoD....+....h.l....l....h.hu....h..h.hhls..s.lhallh+Rl...........	0	69	131	200
+4383	PF03911	Sec61_beta		Sec61beta family	Yeats C	anon	[1]	Family	This family consists of homologues of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG. It consists of a single putative transmembrane helix, preceded by a short stretch containing various charged residues; this arrangement may help determine orientation in the cell membrane [1].	19.20	19.20	20.20	20.70	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.80	0.72	-4.15	33	504	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	411	11	343	453	48	40.20	40	41.61	CHANGED	ouuull+aYs-.-sp.GlKlsPhsVlhhSlsaIshVllLHlhu	...........uushl+aYT-.-us.GlKlsPhsV.Llh.SlsFIssVhhLHlhu...........	1	104	195	283
+4384	PF03839	Sec62		Translocation protein Sec62	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.40	22.40	22.40	22.50	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.72	0.70	-4.94	6	341	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	280	0	226	348	2	199.00	29	55.86	CHANGED	sK+phFFRsK+ll+hLpstchKppKsKspsc.s........K...psp-cppchhKphhpss.s.tscK.....l.sppttp.cKKc.pKclc.Lpl.pcsQhFsD.s-hYVWlY-PlPhpsalhGllhllull.AhsLFPLWPhhhRpGVYYLSlGuhGhlushhslAIlRhILFl...IlaslshG+.thWlFPNLhtDVGFl-SFpPLYsachp.s.p+sphKKccKsKpKKKcKss	.................................................................................h....ha+hh.+h..h..hh.p.th.tttt....p...t.........................t......pt.p....h..p.p.....h...t.......h.....hp..h.tsp+......................tp........t..p.t.t.c..c......p+..ph+....L.ch.....pt..cQhhh..D...s..t.hY.VWlY.-.s.s....p.hhphlhuhlh..llull...AssLFPLWPhhhRhGV....a.YLSlushuhluhhhslAl...............hRhIlFh...lhahhs...h.thWlhPN.Lh.p.D.l.GFh-SFpPlasap.p.......pt.p...Kp.p.t+t..........s.................................	0	76	124	185
+4385	PF01369	Sec7		Sec7 domain	Bateman A	anon	Pfam-B_1629 (release 3.0)	Domain	The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the Pfam:PF00025 family [2].	21.10	21.10	21.20	21.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.26	0.71	-4.63	140	2266	2009-01-15 18:05:59	2003-04-07 12:59:11	15	40	354	21	1387	2049	18	181.20	34	16.19	CHANGED	p........pth.................c...h.........pshptFs......pp..scculphlhppsh.h..................ttpsspp....lA..........pFL.t.psss...........ls+ptlG-aLuc...tpshs.................................hplLctalch.acFp..................shslspALRphLppFcLP....GEuQpI-RllcpFu....................................p+Yh..........................................................................................................................................................................p.sN.........s.........................................sh.atss..Dssal...LuaullMLNTDLHNs.p....l+.p+........................MohpcFlcNsc...........................uhs.........supc.hsp-hLpplYc.........sIpppcl	....................................................................t........h.....uhphFN.p.....Pc.......cGlphL.ppshl..............................................tpss.pp.lA..............pFL..h..ppcs...............Ls..+..phlG-aLGc......ppphs..............................................................hpVLc.s.al.ch....a-Fs..................s.h.p.lspAL.R...............pFL..t..p..F+LP......G.E.u.Q.c....I-Rl..h-.tFu...............................................pR.Yh...................................................................................................................................................................................................................p...CN...Pt....................................................................................................................................hFtss....Dssal....LuaulI.hLNTDlHss..s.........l..+...cK.........................M.ohccFlcN.+.................................................Gl.s........sG...p....D..lsc-.......hL..........pslYppIppp.h.....................................................................................................................................	0	457	692	1048
+4386	PF01043	SecA_PP_bind	SecA_protein; SecA;	SecA preprotein cross-linking domain	Finn RD	anon	Pfam-B_507 (release 3.0)	Domain	The SecA ATPase is involved in the insertion and retraction of preproteins through the plasma membrane.  This domain has been found to cross-link to preproteins, thought to  indicate a role in  preprotein binding.  The pre-protein cross-linking domain is comprised of two sub domains that are inserted within the ATPase domain [1].  	23.00	23.00	23.20	23.00	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.58	0.71	-3.72	120	5736	2009-01-15 18:05:59	2003-04-07 12:59:11	15	29	4782	29	1118	4232	2582	118.40	41	14.40	CHANGED	s.scp...ssphYppssplsppLpc..s.....................DYplDEKs+sltLT-pG...hp+sEchh.....hl.......................................ssLYsspsh.phh+alppAL+A+tLFp+Dh-YlV.c.Ds....c.....VlIVDEFTGRlMtGRRaS-GLHQAIE	.....................................................s.ppsophYtpsscll..p.L.p.c..p..........................-YplDEKs+sltLT.EpGl.pc.sE.chh......tl...................................................................-sLY.s.s...p.Nh.....sLh..Ha..lspAL......+A+hLap+DhDYlV......p.....-.G..........E.............VlIVD.E.aTGRhM.t......G.RRaS-GLHQAlE.........	0	393	750	958
+4387	PF02556	SecB		Preprotein translocase subunit SecB	Bashton M, Bateman A	anon	COGs	Family	This family consists of preprotein translocase subunit SecB. SecB is required for the normal export of envelope proteins out of the  cell cytoplasm [1].	20.80	20.80	21.50	21.30	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.78	0.71	-4.61	114	1987	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1915	16	404	1065	1207	142.90	37	93.68	CHANGED	Mu-ppp..................tPp.hslpphYlKDlSFEsPsuPplF..tpphpPclslplsssuppl...............s..-shaEVsLplslsu+hp..pp.............ssFlsElp.AGlFpI........p.slsp.-plp.hLtltCPslLFPasRchluclspcGGFPPLhLsPlsFsALYppp...h......tppps	..................................................................................p.tFpIp+lYsKD..lSFE.sPsuPplF.....ppch...pPclp..lsl.sstup.pL...............u...-sha.E..VlLpl..oV..o..u.p.s.-c.............ssFlsEV..p.Q.uG..IF.s.I.........t..s.lps.p.ph..sph..LushCPsILFPYARcsIoshls.+.Gs.F.P.tL.L.s.PlNF-ALahphhpppt.t.............	1	112	227	308
+4388	PF02355	SecD_SecF		Protein export membrane protein	Bashton M, Bateman A	anon	Pfam-B_844 (release 5.2)	Family	This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.90	0.71	-5.10	19	8057	2012-10-02 18:57:54	2003-04-07 12:59:11	11	21	3723	9	1953	12076	6096	184.70	28	42.02	CHANGED	thpshhcshss.shphhphchVGPsluppLtppulhAlhhAhlhIhlYlslRFch.hAhuAllA.LhHDlllslGhhulht.....l-lshssluALLTllGYSlNDTlllFDRlREs...hp+.pptshpclhshulspTLoRTlhTohT.....sLlsllsLhlhGu.....sslpsFuhshllGllsGTYSSlalAssllhhhtpc	.............................................................h..hhh..............h.phhp.tcsV....GPs..l.G......p.-..h...h....p...p....u....l....h....A...h.....l...l.u...l....l....h..l..h...l..a...h..h.h....h...a.....c.....h.....t.....h.........u....l..s...A....l..lA....L.......h..t..s..l...l..l..h...l..u....l...h...u....l..h..t................hpl...s..L..s..s..l...A..u....l..lh..s.l..Gh..u..l..ss.sl...l....l...a-...R.I...REp........................l..+...p...................s....p....s...h.....t......p....s.l.s..p....u...h...s...p...s...h....s...p....h..l...s.o....s....l.T........T...l..l...s.s..l....s....L...a...h....h....Gs.............us.l...+..G......F....A...l.....s....l.hl..G..l.l....s..u.h....a.o.ulhlupslh.hh...hh.........................................................	0	650	1298	1669
+4389	PF00584	SecE		SecE/Sec61-gamma subunits of protein translocation complex	Birney E	anon	Swissprot	Family	SecE is part of the SecYEG complex in bacteria which  translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha  translocates protein from the cytoplasm to the ER.  Archaea have a similar complex.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.50	0.72	-4.39	185	4664	2009-01-15 18:05:59	2003-04-07 12:59:11	15	11	4540	10	1213	2641	1958	56.60	28	61.98	CHANGED	phhp.FhcpspsEl+.KVsWPo+cEshpsThsVllhlllhulhlhhlD.hhhthll.phlh	............h..hp.Fh+pstpEl+.KVsWP.........o+cEhhpsTlhVhshshlhu....lhlas.lD.hllstllphl.............	0	411	783	1027
+4390	PF03840	SecG		Preprotein translocase SecG subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.50	21.50	21.70	21.60	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.46	0.72	-4.24	183	4339	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	4294	4	929	2471	1834	73.50	31	72.34	CHANGED	hsllhllhlllulhLlslVLlQpuKG.uuluush.GGGu..stolFGup.sutsh...Ls+hTslluslFhlh.ulsLuhlsp	.......phLlllhlllulhllhllLlQpu.Ku.ushuusF..uuGu.....ptslFGsp..tut..sh....LsR.hTs.l.Lu.slFhlh.slsLuhl...........................	0	319	620	789
+4391	PF04856	Securin		Securin sister-chromatid separation inhibitor	Mifsud W	anon	Pfam-B_4643 (release 7.6)	Family	Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss [1].	20.30	20.30	23.60	33.30	18.90	18.20	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.90	0.70	-4.65	8	108	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	70	0	48	106	0	208.00	36	95.25	CHANGED	hssllhss+EN......usPsstlppscuhh.............................................+.PLuStsp..s+opu................................................tssshpL.+h...Gplhs.shslspsspKuLsshD....pslpsKsst..........pscpsshsscshs.puKKlpuu................................................schshEhhPchp+.hPapP.GaE..uFD........s.-cplp+LsLps..........sPht.....h.hhs--ptptp.hpl.s.sP.......................Lc.ssls.cus.............................................shsuLssl-l	..................................................MssllassKEN..........tpPu.pp.lsspculh.................................................Luotss......hKuhs....................................................tpsplshs+h...GKshss..s.....u.....ls.KssRKuLGsVs....tpsscspssh..................................pp+psshss.cc..hocpss..Kspou.............................................................sssss-saPEIEc..hhPasPl..sFE..oFD.......hPtEcpIu+LsLss..........lPLh.......h.pE-.c..c..pc...phss..P.......................lch..sp.s.E.us..........................................................hhps..............................................................	0	6	13	23
+4392	PF00344	SecY	secY;	SecY translocase	Finn RD	anon	Prosite	Family	\N	22.20	22.20	22.30	22.20	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.15	0.70	-5.52	157	6369	2009-01-15 18:05:59	2003-04-07 12:59:11	15	14	5237	19	1533	4121	3873	333.00	34	79.26	CHANGED	olhuLGIhPaIoASIIhQLL...................shspLtclppp.GcpGRc+lsphoRhhollluhlQuhuhshhhtths.........................hh..lhhll..pLssGohhlhWLuEhIoc.hGl.G.NGlSLlIhsuIl.sslsts................................lh...phhphh......................t..hshhh.........h........lhhllhhlhl.lhhllalppup++IPlpas+p..............tsp..psa.lPlKlNhuGVlPlIFAsul..lhhPt...hluphh......pt......................................t........hhtp.lshhh...................................hpshhY.hhlahshhlhFuaFas.shshsPc-lAcsl++pGsaIPGlRPG.csTpcaLs+lls+lohhGul.aluhlullP..pllsshht..........................h..huG.TulL....IhVu....lsl-...hhp	..............................................SIFALGIhPYIo......ASIIhQLLp.................slhPpltc.hpKp.G-tGR+KlsphTRY.hTllLuhlQuhuhsh...shsshssh.t.......................................shh..lhhslhLssGohhlh.......WLGEpITc.+Gl.G.NGlSllIFuGIluslPts............................................lh.p.hhpthh.........................................p..s..t..h.shlh.......h.........lhlll.hhlhl.hhhllalp........pupR+I.P.lpYu++................htsp..soalPLKlNhA..GVIPlI....FASSl..lhhPt....sls..pah..sss.................................................t....hh.t.p....lst...hh...........................................s.spsla...hllYsshIlhFsaF...Ys..slt.hNPc..-hA-.....NLK....Kp.Gual..PGlRPG.cpTtcYlscllsRlTh.hGul.alshls.llP...h.htthhs..........................shh...hGG.TS.LL....IlV.sVsh-hh.......................................................................	0	523	976	1295
+4393	PF04628	Sedlin_N		Sedlin, N-terminal conserved region	Mifsud W	anon	Pfam-B_5308 (release 7.5)	Family	Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400) [1]. This family represents an N-terminal conserved region.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.85	0.71	-4.29	32	687	2012-10-04 00:47:01	2003-04-07 12:59:11	8	10	305	4	469	992	6	133.60	27	84.69	CHANGED	IlGp.....pDsPLaph-Fssst..ps...........................................ppL...tpFlsHuuLDll--hhap..................................ssshaLttlDpa....pphhl.oualTsuplKFlllap..................................................shs-ssl+pFFp-la-hYlKhlhNPFY..........................p.ss............sIp.Ss.....sF-p+lppluc+	............................................................................................................................lluppspPla.hphss.tp..p.t.t....................................................................................t.l....palsHuuLDll--thht.......................................................................ssshaLt...........hl....p.ph.......pp..h..hl...u...a.l..........T.s......o.......p.......l......+..Flllhc..............................................................................shp-...ssl.+...s......h.Fpcla.ph.Yl.c.h.h.h.NPFY............................p.s..ss.................Ip.S.......tFcpplp.hh............................................................	1	166	259	386
+4394	PF00477	LEA_5	seed_protein; 	Small hydrophilic plant seed protein	Finn RD	anon	Prosite	Family	\N	20.60	20.60	21.10	20.80	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.65	0.72	-3.78	5	271	2012-10-01 20:07:30	2003-04-07 12:59:11	12	10	102	0	87	294	3	71.90	39	87.44	CHANGED	MASG.........QEcREELDcRAKQGETVVPGGTGGKSLEAQEHLAEGRS+GGQTRKEQLGoEGYpEhGoKGGpTR+EQhGpEGYpEMGRKGGLSTpDcSGuERAA-EGI-IDESKF	....................................................................................Eu..tp....+GGpsppcphGcEhYpEhGpKGGp.sptcphsp-hYpEhG+KGG......u..s.p.p...................................................	0	20	59	77
+4395	PF03841	SelA		L-seryl-tRNA selenium transferase	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.03	0.70	-5.72	11	2029	2012-10-02 18:26:03	2003-04-07 12:59:11	8	7	1584	2	363	1893	697	327.50	37	78.46	CHANGED	VlNhTGsVlHTNLGRAlhu....-cAhpAshpuhpc.ssLEaDL-sGKRGsR.salpcLLpcLTGAEsuhVVNNNAAAVLLsLsolApGKEVIlSRGELVEIGGuFRIPDlMcpuGs+LhEVGTTNRTHl+DYcpAIspNTAhLhKVHoSNYplpGFTppVsht-LstLu+EhslPlhpDLGSGsLlDLspYGlst.EPTVp-tlupGsDlVoFSGDKLLGGPQAGIIVG+K-hI-+lpppPLpRALRlDKlsLAuLEATL+LYlpP-+htc+lPTL+hLopshctl+tpApRLpthLtstLu.t.hpVpltsuhuplGuGShPhpcLsShslolpscps......slsuLptthRths.PlIGRlc-stlhLDlRoLt	.............................................................................................................VhNhoGsllHTNLGRu..s....ttshpshtpshpt.ssl.E.h......sL.p......p..u......t......R.......u..p.R......p.....h.....l.t.p......h.........l......p.p........ls.u.....A...E.......s.......A....h.......lV.N.......NN...A..A.A.V............h....L.........h.l....s.................s.h....u................p.s................+................E....VVl........S..........R........GELV.EIGGu.....F..R..l....s..-.l.h.p.t...........u.....Gs..pL......h..E..V..G........o......o..N....+...T...+...h..p..DY...c.....pAI......s.E...p..T.Ah..L..h+V...H.SNaslpGF..pptl.sht-ls.t.l...u......+c...........t.............s.........lPllsD.lGS.G...h....c.h.........t.hh..h.....Es.t.h.p.phl.tsGsDLVsFSGDKll...GG....P...Q...A...G.lIl.GK....K.p.....hI..s....p.....l.....p......p.....p......s......L....t..RAl....R.lsKh.o.Lu....uLpss.L...chY.l....p........p..t........p.plss..hph..Lp.ts....t.lt.tA.p.l....lt..................................th..s.u..lGuGs.hP....l.shhh.h......................tht..h.+........sllsRh.pt.hhh-hpsl.t..................................................................................................	2	127	232	306
+4397	PF04593	SelP_C		Selenoprotein P, C terminal region	Kerrison ND	anon	DOMO:DM04433;	Family	SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [1]. It is thought to be glycosylated [2]. SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity [1]. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage [2]. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function [3]. The N terminal region always contains one Sec residue, and this is separated from the C terminal region (9-16 sec residues) by a histidine-rich sequence [2].  The large number of Sec residues in the C-terminal portion of SelP suggest CC that it may be involved in selenium transport or storage. However, it is also possible that this region has a redox function [2].	19.20	19.20	20.70	49.00	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.37	0.71	-4.36	4	16	2009-09-13 02:32:08	2003-04-07 12:59:11	9	1	10	0	6	37	0	124.80	54	34.28	CHANGED	GQHRQGH.EssDhs.ASEuLQ.SLsQ+KLUR+tCINQLLCKLsc-SEuAsSSCCCHCRHLIFEKoGSAITUQCsENLPSLCSUQGLhAEEpVhESCQsR.PPAAUQ..uQplsPTEASssUSUcNpsKKUKUsSN	............................G.pRpGH.-spDhs.uSEslQ....Q+KLsRK..RCINQLLCKhscDScsA.uSCCCHCRHLlF.Ec.oG.SAlTUQCsENLPSLCSUQGLhAEEN.lhESsQsR.hPPAAUph.SQ.hsPsEA.sssUuU+ppsthscs..N.	1	1	2	2
+4398	PF04592	SelP_N		Selenoprotein P, N terminal region	Kerrison ND	anon	DOMO:DM04433;	Family	SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [1].  It is thought to be glycosylated [2].  SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity [1]. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage [2]. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function [3]. The N-terminal region of SelP can exist independently of the C terminal region.  Zebrafish selenoprotein Pb (Swiss:Q98SV0) lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported [2]. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins.  It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions [2]. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding.  Binding to heparan proteoglycans could account for the membrane binding properties of SelP [1].  The function of the bacterial members of this family is uncharcterised.	22.90	22.90	23.40	23.30	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.84	0.70	-4.98	6	83	2012-10-03 14:45:55	2003-04-07 12:59:11	9	4	48	0	49	89	1	177.60	34	63.13	CHANGED	QspSShCK.PPpWpIcDpsPMhNuhGpVTVVALLQASUahCLlQASRLpDLRlKLcppGYoNISYhVVNcQu.pSphhascLKc+luEcIPVYQQ-.sQsDVWpLLNGsKDDFLIYDRCGRLsYHLuLPaSFLoFPYVE-AIKtsYCEchCGNCSLso.ps.-.CKssTh...........tsssKssEsp.....sct.HsH.....Ht++HsHsHcH.s.....ssphpcs.pss.sstsp.Ps..uh.HHHH+H+	...........................................................................hs.h..............h..phtsLp.+Ltpp....Gh.slpahlVN....pps...Sp............h............ha..Lpp.......pss......tl.......sVYp...Qp.tpsDlWphLsGs...KDDFLIYD..RCGRLs..YHlsLPaS....hL...pasYVEtAI+hsYpcphCGsCo...hp.s............t...s......p.spth......................t.pps..p............t.....p.......................................................................................................................................	0	10	14	34
+4399	PF01641	SelR	DUF25;	SelR domain	Bateman A, Enwright A	anon	Pfam-B_1539 (release 4.1)	Family	Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterised with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidised methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR , evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain Pfam:PF01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc [2]. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family [1]. This family has methionine-R-sulfoxide reductase activity [2].	21.90	21.90	21.90	22.00	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.52	0.71	-4.43	18	5387	2012-10-01 21:11:27	2003-04-07 12:59:11	13	18	4111	31	1382	3866	2926	121.70	48	59.33	CHANGED	c-Eh+psLos.QacVhpppuTEpPaTsEYscpaEcGIYsslssGpPLFpSpsKF-SGCGWPuFhcPlspcu.IphptDpShsMpRsEVpstssDuHLGHVFs.DGPpp....ssGhRYClNSAuL+Flst	.......................................t.tch+ppLo.s...pYtVspcpGTEtP....F.....o.uc....Y...h........c.....p.....t.c...p.........GlYss.h..ssGpPLF.....pS.p.....sKF...-...SGC.........GWPS...Fhc.P.............l.......ss....p.......s........l.......p..htp.......D.......t.S........a............G..............Mt.RsEV+stpssuHLGHVFs.DG..P......ps........s.GlRYClNSsuLcFhs.t........................	0	441	862	1147
+4400	PF01403	Sema		Sema domain	Bateman A	anon	Bateman A	Family	The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance.  Sema domains also occur in Swiss:P08581 the hepatocyte growth factor receptor and Swiss:P51805	19.10	19.10	19.10	19.20	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	433	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.70	0.70	-5.96	26	2637	2009-09-11 14:23:39	2003-04-07 12:59:11	14	95	167	27	1239	2166	0	367.60	25	40.30	CHANGED	aphhhhc.tpspLaVGA+stlasLslpslp....ph...pplsWsus...ppppcpChh+GKs......ts-CtNal+lLtshsps.+LhsCGTsAapPhCphh..plss.....................................aph.stpp.sGpucCPasPppspsulhs.s.....sp......LYuuoshD......Fhup-ssIhR.hu........ptssl+Ttht...sphhLstPpFVsuasIs.s.t......pschlYFFFpEsus-tt.ts....tcslaoRluRlC+sDhGGpchlp.spWooFLKARLsCShPu..t.s..haFspLQssahl.sss..........pssllaGVFoTspsshtu....SAVCsaslpsIppsF.pGsatpp...csspppWhshps.chP.PRPGpCsssst.........thPDpslsFh+sHsLMtpsl.slpptPlhscpssphphTpIsVD..plpstssp.asVhalGTspGpll.hhlslspss..s...hhlEEhplhpss....tPlpshplsppp	.......................................................................................ptplalGu..h.stlatls.ts..ht..................................tht..ss........tph....p..p..Ch.....tspt..........................ppst.Nh.....h.+....l..l.........................h....s...p...........p...pL...............hs..CG...o.ss.ps.hCthh....phss..............................................h.p.h...........t.....p............p.spsts.s..h..sstts.t...s..ulhs.s.....................sp............................Las.u.s...shs.......................a.sps.........h...l..h........R.tht.......................p.t.s....h.c..t..........s.t...ph..l...p...........t.....P..p...Fl.....t....u.....h.........h...............shl..Y..Fh.a.p.ch..shphp............................tp..hh...hoR...lu.R...lC......p.....s..D.G...s..t.p.hl........phhs.....o......a.hcs.............cL.C.shss...............t.........has....L..pssh.h..h.s..tt...............................p.llaulF..o....s..s...s..s.h.s..........................SAl...Csash.p.....s..lppsF..p...u....htpp....p.ts.t........p..t.h...h...s..htt....t....hs......s...+......s.s....t.C..s.ts................................................................ph.s-phh..s...h.h.....c....p......p.s.......lh..........p....h........sl....t..t......p......Pl...hh.....p....p.....t...s..............................hTplsVs........t.s...t....s.......a....sVhFlG........T.....p..p..Gplh..hl..h............tt.............................hhtphthh....................t................................................................................................................................................	0	199	302	687
+4401	PF01118	Semialdhyde_dh		Semialdehyde dehydrogenase, NAD binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1079 (release 3.0)	Domain	This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.45	0.71	-3.81	188	10449	2012-10-10 17:06:42	2003-04-07 12:59:11	19	35	4748	117	2601	11025	5845	122.70	26	35.48	CHANGED	+VullGAoGhlGpcl.lclLpp..c...lchhhlhuspp..psGpphsthh.............htshhlps.......p.tth...ppsDllhhu..tssssupphssph..hptGh....hVID...ousaRhcs........................csshslPEl..N...tcplppt	...........................................plullGAoGhlGppl..l...p.h..Ltc......c......s.....l.....p.....h...h......h..h.....huosp.......ps..Gp..pl.s..h................................h..p..sh..s.lps.......hs...psh......pss.D..lsh..h....u....s..u....s...s...s....o..p......c....h.s...s..ph.............hp..s.Gs...........hVI...D...sou..s..a.R.hps.....................................................csshslPEl...N....ctlt.....................................................................................................................	0	809	1648	2203
+4402	PF02774	Semialdhyde_dhC		Semialdehyde dehydrogenase, dimerisation domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1079 (release 3.0)	Domain	This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase	20.90	20.90	20.90	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.50	0.71	-4.43	32	8792	2012-10-02 22:00:43	2003-04-07 12:59:11	13	14	4668	113	2044	6116	4228	174.30	26	50.65	CHANGED	LpPLhct..stl.ptlhVsohQulSGAGtp...........................................tssshshslshNllPalss..cct..poccchphhs-spphlshss..........u.CsRVPlhcGHopslphcht.....pshslccshphhtst.........stshlhs.....p.phPpsttsts...ssss.VGRlRpDshtsp...lthhsluDNlh+	................................................................LtPLhc..t....htl...p.p...l.sl.s.oh...pul..SGAGt..p.......................................................t..s..s.h.......h.......s.h........luhNll......Pah..ss.......h....cps..........ps.cc..E..h....+..h.h..s...-...s...p.....c...l...l.....s.ss........h................s.slplP....shcGHspslp.hc.ht......................psh.slpch...hph.h..tps.............................................tshlhsps...............ttthPpsh..tssG........ssts.lG.p.lR....p..D....t..s....sp......hlthhsluDNLhK............................................	0	662	1325	1741
+4403	PF03925	SeqA		SeqA protein	Bateman A	anon	COG3057	Family	The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [3]. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner [3]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [4].	22.70	22.70	23.00	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.24	0.71	-4.59	37	801	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	780	13	101	335	9	177.20	64	98.90	CHANGED	MKpIEVDEELY+YIASpTpcIGESASDILRRLLslssp......................pshshspPs.t..............................................................................s.spsttctVp.................slcpLlps-chsppctAVsRFlhlLssLYptsspsFspsh...plpGRsRlYFApscpsLLtuGss........oKPKpIPsoPFWVlTNsNTuRK+thLpplhtphthsspll-clpshl	.....................................................................................................................................................MKTIEVDDELYpYIASHTcHIGESASDILRRMLKFoAss..........................t.....usPsht........................................................................ps.t...h...sc.sps...spsl+D+VR........................AMRELLLSDEYAEQK+A...V.N..RFMLlLSTLYoLDspAFAEAT..ESLHGRTRVYFAuDEQTLLpNGNp........TKPKHVPGTPYWVITNTNTGRKpSMlEHIMQSMQFPAELIEKVCGTI..............................................................	1	13	36	70
+4404	PF04360	Serglycin		Serglycin 	Finn RD	anon	DOMO:DM07201;	Family	Serglycin is the most prevalent proteoglycan produced in haemopoietic cells. Serglycin is a proteinase resistant secretory granule  proteoglycan [1].	30.00	30.00	32.00	30.80	28.90	27.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.03	0.71	-4.48	3	52	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	31	0	21	58	0	122.00	45	76.59	CHANGED	QpLLpCoRLVLALAFILVauSSVQGYPsRRARYQWVRCsPDSNSANCIEEKGPtFDLLsGESN+IPPPRTDl.PlhpppsLN-lFPLSEDY..............................SGSG.GSGSGSGSGSGSGFLsEMEQEYQPVDENDAFYaNaRShDRNLPSpNQDLGQDGl	...................ss+lsLsLAllhhLtsus.pGhPsp..+ARYpWV+CsPDosSANCl-EKGPhF-L.PGEuN+I.s...hsD.hshpp...p..shschFP..l.SE..-h......oG..sS..G..SGS.GuuSGSG.....hsphc.-h....h-pps..a.s..s......................................................	0	1	2	5
+4405	PF00450	Peptidase_S10	serine_carbpept; 	Serine carboxypeptidase	Finn RD	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.43	0.70	-5.31	67	3902	2012-10-03 11:45:05	2003-04-07 12:59:11	17	45	756	20	2456	3840	269	353.80	21	80.72	CHANGED	PG.....ts...hsh...cpaoGYl.......sls.ttpsppLFYaFh....ESpp....sPppc.PllLWLNGGPGCSSls.Ghh.ElGPFpls......ss..sLhhNsYSWscsANllFLDpPsGsGFSYo..sssss.......hptsD....................ppsApDsatFLtpahpc.FPca....tsp..cFYIsGESYAGpYlPtluptIhptspt..............tlNL+GhhlGNuhs-s......hhphsshhs.....ahattullo.-ctacphpptCphs..............................stsp..tppChsthpphtt.................................slshYsIhpssh..............................................................shsshs.phspt..ahNptsVpcALph.....ss.hpWptCsp.tl........th..sch.pshhshhp...pllpss..l+lllauGDtDhhsshhuspthlcs....LshsstspapsWhh........................sspluGaspsY........ts..loFsoV+GAGHh..VPh.pPptuhthhppalsu	.....................................................................................................................................sGal...........................tht.........s....t...p...hF.aa.......hh..........................pu.pp...........ss.t.pp....Plhl.....Wl.............s.G...............G..........P.............G.s.SSh.......h..u......hh..E.h.G...Ph.thp..............................t........t..h......h........Ns..h.o.Ws...p..........h..............u............sl......lal..-p..............Ps....G.......s..........Ga......S..h..s...psstt...................s.p...............................................pt..s.....u.ps...hhthl...p..t........ah...pt....a...s.pa.....................t..s.......s....hals..G........E....SY.u......G.....hh..hPh..luthlhptt.t.................................hs.Lp..........G...h.h.l.s.........s...sh...h..s.....................p.h....thh.........................hhh........h....s.....h....l.....s........p......p...........h....p.....t...h....t...t.......h.......................................................................................s........t....h.t.h...............................................................t.............ths.hshh...............................................................................................................................................................t......h...........a.....h..s......p......t..l...p...p...s.lt.h......................tat.ss......l................................t..t..................s....h...h..........h...h..................tl..l...pt.t.........hpl.hl.h..........s.....G.p...............hD.h.h.s..............s..h...h......u...........s....phh.hpt.....................h.t.h....h...............a...................................................................tt....hG...h............................tt......hshh.l..h...........tuuH........hs.........t......s..s..hh..............................................................................................................................................................................................................................................................................	1	823	1473	2074
+4406	PF00079	Serpin	serpin; 	Serpin (serine protease inhibitor)	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.	21.70	21.70	21.70	21.70	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.21	0.70	-5.32	180	5658	2009-01-15 18:05:59	2003-04-07 12:59:11	15	39	760	254	2183	5686	67	297.10	23	87.17	CHANGED	pusssFuhcLa+plspps.......ppNlhhSPhSl......psuLuhlhhGApG..pTtppl..tpsL...th....................................hstpp.......h.tt.........................hppl.hpplpp..............................tshplphANtla..h....p..cs.hplppsFhptscp...hYpup.hpslDFpsssp.utppINsWVpcpT...............pu+Ipcllsst.lss.s..TphlLlNAlYFKGpWpp..tFstppTppp.sFa..hsp.......spsh.pVsMM.ppp.....spaph......t.p....sspl..lcLPY........................ps.....sh.SMhllL..........P........su.lp..plc......ppLs.tt.....lpp.....hhpphp...hp......htl...tl..PKF..plpt....sh..cL.ppsL.pphG..lpchFs.spAD.hSsls...............................................................................s...t.LhlScllHKuhl-VsEcGoEAAAuT.........................................................Fpss+PFlFhIpcppo........................tslLFhG...+lhsP	.........................................................................................t.....hshph.hp..h..tt............ttN..hhhSP.h.ul........shu......hh......h.G...u.......p.......s.......p.......T...tt..p..h....p...s.l..th............................................................t.tp...h................................................h.t.pl..hptltt..................................................................tt.t..l.p.h..sst..l..a..h.............p......pt.....h.......t...h........t.p....ah..p...h...pp.........ha..t.............sp....htth.s.Ft.....pt.....t....s........t...p....tI...N..p.a.l..pp..p.T..........................p.s.p.....I..t....p....l....l..t.t.........l...s......t............s.......hh..h...ll.Ns..l...aF...+.........u.p...Wp..p......F...p.....p.........t..T.p.tt......Fh.......hsp.........tp...t......h...tV.hM...tp...........t.t.h..h.........................h..tt...t..h.....pl....lp.lPY....................................ps..ph..ohhl..lL.........................P.............pt....ps....lp....pl..................p.p..l.s....tt...............lt.p.....h..h.p.t.hp...p........ht.........l................hl..P..+F....pl....p..t....ph....s.......l...pphL..p.p....h.G......hp...p....hFs.....t..pus..hsths.......................................................................................................................................................................t....ttlhl..s..p..h..h...pp...s.h......l...p.............l..s.Ep..G..spu.s...u.so.................................................................................................h....h.s+P..Fhh.h..lh....p...p.......t............................lFhGph.................................................................................................	0	518	734	1365
+4407	PF02403	Seryl_tRNA_N		Seryl-tRNA synthetase N-terminal domain	Mian N, Bateman A	anon	Pfam-B_518 (release 5.4)	Domain	This domain is found associated with the Pfam tRNA synthetase class II domain (Pfam:PF00587) and represents the N-terminal domain of seryl-tRNA synthetase.	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.44	0.72	-4.03	89	5178	2012-10-01 23:07:44	2003-04-07 12:59:11	17	14	4789	32	1407	3708	1996	107.80	30	25.05	CHANGED	MLDl+hlRp....Ns-tlccpLppRt....ss.hsl-cllpLDcc+Rplhhcs-pLpscRNphS+pIuptcppt.....pcsstlhtcspplspclpsh-t.clpplcsclpphlhslPNlP	.........................MLD.l+.hlRp........s.-tVtcpLt..pR................stt..h..sl.-....clhpL.....Dp.cR...Rpl.....hs..csEpLpuc.RNphS...Kp....I...upt...Ktpt...................--spsl...htc..h....pp....lupclc..shcs.clsplpsclpplhhslPNlP...............................................................	0	483	906	1191
+4410	PF01445	SH		Viral small hydrophobic protein	Bateman A	anon	Prodom_1504 (release 99.1)	Family	The SH (small hydrophobic) protein is a membrane protein of uncertain function [1].	21.90	21.90	21.90	35.70	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.01	0.72	-4.31	12	328	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	18	0	0	315	0	56.10	83	99.85	CHANGED	MPAIQPPLYLTFLLLILLYLIITLYVWll.TITYKTAVRHAALYQRShFRWSFDHSL	MPAIQPPLYLTFLLLILLYLIITLYVWIlLTITYKTAVRHAALYQRSFFRWSFDHSL.	0	0	0	0
+4411	PF00017	SH2		SH2 domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.69	0.72	-4.17	58	9081	2012-10-01 22:44:06	2003-04-07 12:59:11	19	379	283	390	4864	8244	21	78.00	27	14.81	CHANGED	WaaGploR.....p-AEchLhp......tpsGsFLlRcScs.p.Gs...aoLSVppps.........pVcHa+Ipppsss........halssptp..FsoLt-LlpaY	..................................Waa.Gt.l..o..R...............pp..A.EplLtp.................t...sG.s...FL.lR......c..S...ps....p......G.s..........a..s.LS..lptps........................................plpH....h.pI.p..pp...sst................................hh.h......s.....t......t.....tp.......F..s..o..l..pLlpaa...............................................................	1	1219	1597	2956
+4412	PF00018	SH3_1	SH3;	SH3 domain	Cerutti L, Sonnhammer ELL, Eddy SR, Finn RD	anon	Prosite	Domain	SH3 (Src homology 3) domains are often indicative of a protein involved in  signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.20	0.72	-4.57	61	10749	2012-10-02 18:48:24	2003-04-07 12:59:11	23	695	444	373	5929	20245	89	47.10	29	7.39	CHANGED	hALYDapupp..ssELshpcG-hlpllpcsss...sWWcuc.ttt...sppGhlPu	.....................hAlYc..a..p.......u....pp.........ss.......E.......L..o.......hp...c..G..-hl.p..l........l......p...c.....s........ss..........sW.Wpu.ch...tt............sp....p....G.hhPs...................................	1	1639	2410	4041
+4413	PF04908	SH3BGR		SH3-binding, glutamic acid-rich protein	Mifsud W	anon	Pfam-B_6650 (release 7.6)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.23	0.72	-4.05	6	396	2012-10-03 14:45:55	2003-04-07 12:59:11	10	6	165	7	218	466	811	91.70	40	45.15	CHANGED	MVl+VYlASuSGshtIKK+QQ-VlthL-up+IpF-plDIot..cE-pRcaMRcNs....s..p+PssGtPLPPQIFN-DpYCGDYDuFhpApEpNTlhsFLtLs	...................slcVah.uos.oG..s..htIKK+QQcVhthL-A.p+I....pFc...plDIut..sE-pR.caMRcps.........pc..st.suhsLP....PQIFNp...-p....YCGDY-sFh-.ApE.pstl.tFLtL..................................	0	60	87	142
+4414	PF03579	SHP		Small hydrophobic protein	Bateman A	anon	Pfam-B_1121 (release 7.0)	Family	The small hydrophobic integral membrane protein, SH (previously designated 1A) is found to have a variety of glycosylated forms [1,2]. This protein is a component of the mature virion [1].   	21.20	21.20	21.20	107.20	19.50	21.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.11	0.72	-4.62	3	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	10	0	0	46	0	64.00	66	92.80	CHANGED	MsNTSITIEFTSKFWPYFTLlHMILTIISFLIIISIMIAILNKLCEaNsFHNKTLElspuhpNs	MsNTSITIEFTSKFWPYFTLIHMILTIISLLIIISIMIAILNKLCEaNsFHNKTLElspthpss.	1	0	0	0
+4415	PF01488	Shikimate_DH		Shikimate / quinate 5-dehydrogenase	Bashton M, Bateman A	anon	Pfam-B_336 (release 4.0)	Family	This family contains both shikimate and quinate dehydrogenases. Shikimate 5-dehydrogenase catalyses the conversion of  shikimate to 5-dehydroshikimate. This reaction is part of  the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Quinate 5-dehydrogenase catalyses the conversion of  quinate to 5-dehydroquinate. This reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes. Both the shikimate and quinate pathways share two common pathway metabolites 3-dehydroquinate and dehydroshikimate.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.66	0.71	-4.06	44	8457	2012-10-10 17:06:42	2003-04-07 12:59:11	15	52	4195	91	2050	10811	5424	121.30	22	33.35	CHANGED	-LApphhs...tlp.sppsLllGAGchucLlsptLhsp.uscclhlsNRThc+AppLAcch.....ts....shsls-lp...phlspsDlll.ouTuupp.............llspphlcpsh...t.......h.lhlDIulPRslp.tlsthpsshlYslDDLctl	...............................................h.............tlp..sppsL.l.l..G.A...G...G...s.u...c...u.l.h.h...t..L...h...pt...G........s...p......p...l......h......l..s....N.......R......T.......h.......p.......+......A....p......p....L...A...pph.....................t..t......h....p......s....h....s....h....s.....c....lt...............th..h...t...p....h......D....ll...l...s.u...T....u..u.s.h.................................................h............h..............................................................................................h.........................................................................................................................................................	0	611	1298	1762
+4416	PF00464	SHMT		Serine hydroxymethyltransferase	Finn RD	anon	Prosite	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	399	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.06	0.70	-6.10	12	6460	2012-10-02 18:26:03	2003-04-07 12:59:11	14	19	4794	86	1789	5320	4336	351.50	52	88.05	CHANGED	Ls-tDPElashlcpEhpRQpcplELIASENasSpuVh-AhGSsLoNKYuEGYPGpRYYGGsEalDhlEsLs.cRAhchFsh-....hVNVQPhSGS.ANhuVYpALlpPtDplhGLsLscGGHLTHGh.ss.......oupaFcuh.YtVs.cTGhIDYDpLccpApha+PKlIVAGsSAYuRllDat+hREIADclGAYLhsDMAHIuGLVAAGVhPSPF.aAcVVTTTTHKoLRGPRGGhIhh+............-h..-ltcKINpAVFPGhQGGPh.HsIAAhAVAhKpAhpPEFKsYpppVlpNA+AhucsLpcpGYcLVSGGTDNHLlLVDL+s+GlsGscuEtsLtpssITsNKNolPsD.cSshlsSGlRlGTPAhToRGFsEt-FpcVutaI	..................................................................................................tphDs-lhph.l.p.p....E.ht.R.Q..p.pp...lELIASENa....sS......uVhpAtGS......hLTNKY......A.......E.G.....Y.P.......G..+.......R..........YYGGCEaVDhlE..pLAI..-R.AKcLF.....GA.....-.................................aANVQ...........P..H.S..GS.........Q......AN.......hAVYh.AL..L.pP.....G...D....ol............hG.....Ms.Lsp.GGHLTH...G.u.l......sh......................S..G+.h.a....p.......hlsY.Gl..c......c...o...t.hIDY.D..p..l..c...c...h..A..h..c......a.+.....P...K.l.I..l.A..G...h..S.A..Y..s...R...h...l.D...a.t...+...h...R....-...........I....A...............D...c.....V...G..A.......hLhVDMAHlAGLV......A.....A...G.....l..a.....P......s.....P.....l......P.....a.......A....c..l..VT.TTT..HKTLR......G..P.R..G..Gh.IL.sp............................................................................p-htKc..l..N..pAlFP.G.h..Q.....GG.P.L...H.V.I..AAKA.V.A.ht..E.A.h..pP-F.K.pYt.ppVlcNA+shA.....c................s......h......h......p......c.......G...h.cl......V....S...G....G....T......DN.H.Lh..Ll...D...L.p.......s......p.......s............l...o.G+..p.A-.th...Ls.ps..sI...TsNK..N.slPh..D...sc.s...P....h..l..T.S.........GlRlGTPAlToRGFtE..t-hcplAphI...........................................................................................................................................................	0	595	1137	1501
+4417	PF04917	Shufflon_N		Bacterial shufflon protein, N-terminal constant region	Mifsud W	anon	Pfam-B_6667 (release 7.6)	Family	This family represents the high-similarity N-terminal 'constant region' shared by shufflon proteins.	27.10	27.10	27.50	27.10	26.10	27.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.35	0.70	-5.36	3	374	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	230	0	47	352	5	249.60	32	68.40	CHANGED	MKKaD+GauuLEVGAuLLIVlllIuhuAchhpDYLpo+cWQssAcpsNsaToAVRSYVGKNYoTLLASSTTTTPAVITTsMLKNTGaLsSGFSETNS.GQpYQAhIVRNuQNsELLQAMVVSsGGpuhPhsALpQlAKDITsGLGGYIpDGKTAlGAhRSWSlsLSNYGssoGsGHIAVhLSTDDLSGAtEDoDRLYRFQVNGRPDLNKMHTAIDMGSNNLNNVGTVNAssushSGNVuGpNGTFSGulsGNou.....lTAGGDIRSNNGWLVTRNSKGWMNETHGGGaYMSDuSWLRSVNNKGIYTGGQVKGGTVRADGRLYTGEYLQLEKTAVAGASCSPNGLVGRDoTGAILSCQSG	......................................................................................................................................................................................................ttGh....h.p...h.h.....slhl..hhh.hh..hh..h.t...hts...ptht.p...A...pphs...pAsppYlt...cph.........s.sl......st.s.........................Ph.......h.......h......Th....t...Lhp..p..s.hL.suhptp..N...uQp..h.hh....l...h+..s....s...t.....s....st.....h...puhhh.o....p....G....Gp...s..h.............t....t.hh.h....ut.....hs..u.........GG....hl.......t........p.........s..........t..............u...........h..........G...shtuW...p........s.............ssa............u............t.s...........ss....G+lA.....hh.h....tt.............t..s-.......h....LYR..tVsu+P-.hN....tMps....slshssp...slpshtsh.s.st............t....h........................................................................................................................................................s...ts...s.....ssp......h.t.......s.....G..........p.l......pu......p......sph.stthl....pht.t..s..st.Cs..............sGhhu..hs..st.G...L................................................................................	0	12	27	33
+4418	PF02973	Sialidase	sialidase_N; 	Sialidase, N-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.21	0.71	-5.33	6	557	2012-10-02 19:29:29	2003-04-07 12:59:11	11	25	252	12	9	354	128	186.90	45	24.36	CHANGED	l.psh.hE..ssshsIusGpshcLsuEhs...lphL-pGTlllcFKuspps.ulQSLFSlSNupssN..caFplYlsNo.plGhELRsscuhhNYshups..sslhshhtsssshNTlAhKA-.psKpY+LalNGclltshspssspF..IssIsGlsslpLGuTsRtG.sptYsFsGsIsplplYNcsLoD-tLppcTGtTs	..............................................................................................l.pshphp..shphsh.Ssstt.scLSu..Elp....pphp..pu..TV..hMcFKsDsp.s......uh......s...LFulSsup..ttp.....pYFohhl..h..ss..phslEhRsusupt..Yh..ps....hpl..h..st.phspssh...ss.....t.su-....ctphpLYVNG..........lp.....h...s......S.p.s...s....sF..Ipc..hs...sls.+..s.plG.......A.........s...c.R....s....s...p....s.....ha..s..u....shpIcplolaN+ALos-EVpphot...................	0	5	5	6
+4419	PF03482	SIC	sic; 	sic protein	Bateman A, Howe K	anon	Pfam-B_5 (Release 7.0)	Family	Serotype M1 group A Streptococcus strains cause epidemic waves of human infections. This family includes the sic protein an extracellular  protein (streptococcal inhibitor of complement) that inhibits human complement [1].	19.90	19.90	20.60	20.20	19.60	19.00	hmmbuild  --amino -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.13	0.70	-4.78	8	450	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	7	0	4	450	0	193.50	81	91.33	CHANGED	ETYTSRNFDWSGD....DDWPEDDWSGDGLSKYDRSGVGLSQYGWSKYGWSSDKEEWPED.WPEDDWS..........SDKKDETEDKTRPPYGEALGTGYEKRDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWGGPGTVATDPYTPPYG.......................................................................................GALGTGYEKRD.............................DWRGPGHIPKPENEQSPNPSHIPEPPQIEWPQWN...GFDGLSSGPSDWGQSEDTPRFPSEPRVTEKPQHTPQKNPQESDFDRGFSAGLKAKNSGRGIDFEGFQYGGWSDEYKKGYMQAFGTPYTPSAT	................................................ETYTSRNFDWSG...............DDWP.....EDDWSuD........................YuW.....SSD..K........sEDDWS...........SDKKDETEDKTRPPYGEALGTGYEK.RDDWGGPGTV.ATDPYTPPYGGALGTGYEK.RDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWRGPGHIPKPEN.E.QSPNPSHIPEPPQIEWPQWN......GFDGLS.GP.SDWGQSEDT.PRFPSEPRVsEK...P...QHTP...Q.....KNPQES....DFDRGFSAGLKAKNSGRGIDFEGFQYGGWSDEYKKGYMQAFGTPYTPSAT.............................	0	2	4	4
+4420	PF00158	Sigma54_activat	sigma54;	Sigma-54 interaction domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.98	0.71	-4.78	287	23376	2012-10-05 12:31:08	2003-04-07 12:59:11	21	270	3214	38	6053	30277	7477	165.30	44	32.07	CHANGED	llGpSsshpp.lhchlpplA...sos...ssVLlpGEoGTGKEllA+uI.....Hp.......tS.sR...p..st...PFlslNCA..Al..P-s...LlESELFGac+GAFTGAppp+t.GhFEtAsGGTLFLDEIG-hPlshQsKLLRVLQEtplpRlG.u.s.c.s.lplDVRlIAATNcsLpptlp.pGp..FRcDLYYRLNVlslp	......................................................................................lGpo.ss.hpp.lhct.l.p..p....l.A.......t..os.......ss.V.L.I.p.GEoGT.GKE....l....l...A.+.u.l.........Hp..............................tS..s..R.......t.......s....t.......PF.....l...s.....l......N.......C.....A......A..l..........P.c..s..........L........l.....E.........S......E......L.............F..........G..........a......p..........+...........G.........A......F.....T........G......A........p........p.........p.........+.........t.........G...h....F.....E...t.......A......c.......G.....G.....T....L.F.L.DE...IG-h.....P..h.p...........hQ....sK..LLR.V..L....p........-..t...p.....h.......p...R...l.....G...u...s.....p...s.....l...p..l..D.V..R...l.I.u.A......T.s..........c..s...L..p...p.......hl.p..pG.p..FR..cDLaYRLsVhsl....................................................................................	0	2150	3866	5098
+4421	PF00309	Sigma54_AID	sigma54_AID; 	Sigma-54 factor, Activator interacting domain (AID) 	Finn RD	anon	Prosite	Family	The sigma-54 holoenzyme is an enhancer dependent  form of the RNA polymerase.  The AID is necessary for activator interaction [1].  In addition, the AID also inhibits  transcription initiation in the sigma-54 holoenzyme prior to  interaction with the activator [1].	21.20	21.20	21.80	21.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.36	0.72	-4.49	153	2778	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	2568	0	623	2038	696	48.40	41	10.45	CHANGED	.pLphc.sQpLshTPQLpQuI+LLQhoshELpphlppplpcNPl..LEhpc	.............tLpl+.uQpLshTPQLpQuI+LLQLSslELppplpptl-pNPL..LE......................	0	216	410	521
+4422	PF04963	Sigma54_CBD	sigma54_CBD; 	Sigma-54 factor, core binding domain	Finn RD, Wigneshweraraj SR, Buck M	anon	Prosite	Domain	This domain makes a direct interaction with the core RNA polymerase, to form an enhancer dependent holoenzyme [1]. The centre of this domain contains a very weak similarity to a helix-turn-helix motif which may represent the other DNA binding domain.	21.10	21.10	21.90	21.50	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.23	0.71	-4.87	22	2858	2012-10-04 14:01:12	2003-04-07 12:59:11	8	8	2612	2	650	2119	1007	194.30	32	42.31	CHANGED	--Dt...hpshss.st.oLp-HLhpQlsls.hsss-RhIAhtLIDslD-sGYLp.hsLpElsppLs....sphscVcpVLphlQpF-PsGlhARsLpECLhLQL+phs.....h-.AhthlscpL-LLApRDassLt+hstlcE-DLt-hlp.IppLsP+PGspapssts-hllPDVhVRps.sGtWhVELNs-slPRlhlNppYh	.................................................s......htt..h.s...tpoLp-.aLh.Ql.p..l.t....h..o.cp..-.+t..IAphll-slD..-sGYLp.....h..............s........l-.-..l....h..c....phs..................................ls.h..--..l-..t.......l.L.c.hl.Q.p.h.DPsGVuA+sLpECLllQ...Lpphs..........................hhp...A..h.t.l.l...p.c.a...l-.hL....u...p.......+............ca....pp......L.h+.hh........p........l....p.p.c.p.l.....ccsl.s.l.I.p.s.LsP.+.P......G.t..p.h....t....s......s......c........s...p.......Y.......l.......l.PDlhVp..............c......p....s.......s.........c.....a..tVp..L.Nsc.shP+lplsppY............................................................................	0	226	431	549
+4423	PF04552	Sigma54_DBD	sigma54_DBD; 	Sigma-54, DNA binding domain	Finn RD	anon	Prosite	Domain	This DNA binding domain is based on peptide fragmentation data.  This domain is proximal to DNA in the promoter/holoenzyme complex.  Furthermore this region contains a putative helix-turn-helix motif.  At the C-terminus, there is a highly conserved region known as the RpoN box and is the signature of the sigma-54 proteins [1]. 	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.92	0.71	-4.72	29	2839	2012-10-04 14:01:12	2003-04-07 12:59:11	8	11	2603	3	645	2149	926	157.50	46	33.86	CHANGED	psalpcplppApWLl+uLcpRtcTlLKVuppIVcpQcsFLpcG.ptL+PLsL+clA-slshHESTVSRlTssKYltTPRGlaELKaFFouul.uossGu-.tSspAl+thI+pLlssEs..pcPLSDspIsphLccpG.lplARRTVAKYREuLsIPuSspR+R	..........................p.pal+pplp-A+WLl+uL.cpRpcTLL+VupsIVcpQps.FF..............pp.G..t.c.t..hKPh...sL+Dl....Aptl........sh........H.E..S........TISRsos...pKY.lpTP.+G.lF.ELKaFF....o..sp..l..........so...........p......s............G........u...-.......s.............S........osu.....I+s.hl+cLIss...E.s......p..K.P.LSDs.+lspl.Lp.-.pG..I.lARRTVAKYRE.pLsIPsSspRKp...............................	0	223	427	544
+4424	PF04546	Sigma70_ner	sigma70_ner; 	Sigma-70, non-essential region	Finn RD	anon	manual	Domain	The domain is found in the primary vegetative sigma factor.  The function of this domain is unclear and can be removed without loss of function.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.22	0.70	-4.71	124	3805	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	2580	2	391	2852	1705	206.60	36	49.01	CHANGED	aP.....sslshlLppa-+lpstEh..RLsDllsGalDP.......s..spss..t.hssc.spsptsc.................p-------p-.........................-s-sG.DPE.Atp+Fstlccpapphpp.......sl..pcpG+s..spp...stcthptluclFtth+LsPKpaDtLlpplRshh-pVRtpERtIhclsVcpu+MPRcsFl+tFs.GNETshsWlcphls..sp..csauptLpchps-IpcsQpKLhplE	................................................................................................................aPtslshlLppY-+.hp..s-ph..RLoDll...o......GalDPs.................................tttshAss.s..st..l.ss.chsc.s-hs-.....................................-------Dpss............................sps-s-su.DPclAtp+Fuplp....sQachs+c................ul....pc.p....GRs.......ccp........stttht.......pLu-lFpph+LsPKQFDtLVsphRshh-RlRsQERhIM+LCV-pu+MP+.c.sF.lptFs..u..........N........E..........sst.sWh-thht..ts...+sautt...ltchpp-lhcs.p+LttlE.............................................	0	87	203	293
+4425	PF03979	Sigma70_r1_1	sigma70_r1_1; 	Sigma-70 factor, region 1.1	Finn RD	anon	Prosite	Family	Region 1.1 modulates DNA binding by region 2 and 4 when sigma is unbound by the core RNA polymerase [1,2]. Region 1.1 is also involved in promoter binding [1]	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.71	0.72	-4.05	31	3466	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	3283	1	714	2077	1357	81.80	31	15.80	CHANGED	..chspspl.Kp.LIppGKccGa.lTYcElN-tLP.t-h..lss.EQl--lhphl.s-hGIpVl-.....-s-.....p.......tEp.t...sp-csst-Esp	..................h..t..pppl..+p.Llpp.G..K.c.p.G.a..LTYsEl....N-.pLs....sph.......lDu..-.........Q.lE-llphl..sDhG..IpVh-.......ps..s.-s.-.............sh........hhs-p..............tsDpss.....s...........................................	0	240	448	579
+4426	PF00140	Sigma70_r1_2	sigma70_r1_2; 	Sigma-70 factor, region 1.2	Sonnhammer ELL, Finn RD	anon	Finn RD 	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.97	0.72	-7.50	0.72	-4.27	183	8438	2009-01-15 18:05:59	2003-04-07 12:59:11	15	36	4678	31	1886	5884	3958	35.90	42	8.55	CHANGED	sDslchYL+EIGch.sLLos-EElcLA+clcpGtptt.c	.........tDsl+hYL+ElGpl.sL..LT.sE.-ElclA+RlcpG.......................	0	601	1232	1599
+4427	PF04539	Sigma70_r3	sigma70_r3; 	Sigma-70 region 3	Finn RD	anon	manual	Family	Region 3 forms a discrete compact three helical domain within the sigma-factor.  Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role.  Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme [1].	25.30	25.30	25.30	25.30	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.21	0.72	-4.09	82	10957	2012-10-04 14:01:12	2003-04-07 12:59:11	11	41	4723	32	2549	7548	3445	76.80	28	20.25	CHANGED	Epls+lp+sp+pLtQchGRpPoscElAcpLshs.ccVcchhphuppslSLchslupctDsphs-hlpDs.s.ssp-ts	......................................plN+lt+s.p...+p...L.h.......Q.........c...l........G..R..-...Po....s...-E...lA.....cch......s.....h.....s.-cV.....p..ch...L...c...h..u..p..c..s..h...S.l...-..s.....P.....l.......u......p...-....p...D...u.....p......l...s.......D......h...ltDpp...P.p..s..........................................	0	876	1740	2204
+4428	PF03084	Sigma_1_2		Reoviral Sigma1/Sigma2 family	Mifsud W	anon	Pfam-B_1759 (release 6.4)	Family	Reoviruses are double-stranded RNA viruses. They lack a membrane envelope and their capsid is organised in two concentric icosahedral layers: an inner core and an outer capsid layer. The sigma1 protein is found in the outer capsid, and the sigma2 protein is found in the core. There are four other kinds of protein (besides sigma2) in the core, termed lambda 1-3, mu2. Interactions between sigma2 and lambda 1 and lambda 3 are thought to initiate core formation, followed by mu2 and lambda2 [5]. Sigma1 is a trimeric protein, and is positioned at the 12 vertices of the icosahedral outer capsid layer. Its N-terminal fibrous tail, arranged as a triple coiled coil, anchors it in the virion, and a C-terminal globular head interacts with the cellular receptor [2].  These two parts form by separate trimerisation events. The N-terminal fibrous tail forms on the polysome, without the involvement of ATP or chaperones. The post- translational assembly of the C-terminal globular head involves the chaperone activity of Hsp90, which is associated with  phosphorylation of Hsp90 during the process [2]. Sigma1 protein acts as a cell attachment protein, and determines viral virulence, pathways of spread, and tropism. Junctional adhesion molecule has been identified as a receptor for sigma1 [1]. In type 3  reoviruses, a small region, predicted to form a beta sheet, in the N-terminal tail was found to bind target cell surface sialic acid (i.e. sialic acid acts as a co-receptor) and promote apoptosis [4]. The sigma1 protein also binds to the lambda2 core protein [3].	25.00	25.00	26.30	64.10	16.90	16.50	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.37	0.70	-5.84	4	120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	42	18	0	98	0	322.90	50	99.77	CHANGED	MARAhasFhTshFGs.pslPhscpQlopLLpSSNSPWQct..shshslspuhloTsphPhsGShhYQcShLaSuhlPhlLhspDAW+-hpahchsWTsssLsGLVtAssP..AsP.YpPtuupaaDlppYPpWApchR.LpphYP.Lht.TLLNhhphGPlsYV-T.ssMlSGplsshhMohaG+sFtEIAhpLsQosuNhPhtsDusYDpthRhllSLahLSYlGVlpQssTIpGFaFpoKpRGsutEuWhL.Ys.TpupRlplspR+auahssRSPDWNhDhSalhuusLoAhlhSsRQ.PLluNpuVsNpupNhPGaoussGs.V+tlplhshAsEhIcphhhsGllossctpplptpusshpphhpscLssltspDDtL.ptpPphAR.RlKPFssssWssGpottulAuLAshh	.....................................................s.F.Gs.psl.shNcp..SpLLpuuNSPWQhh....h..hu.Glso.os.sPhsGSphYQ.ShLhSuTl.hshtspctWtshphhtLsWos.sLsGLVsA.s.s.AsP.....hQstusph.Dh.sYPpaApc.RthpphY..LhtsTLLshhthGPlhYVcs.ssMhSGtlsphhMs.hGpsFh-hshpLhQus.NhPhp.DusYsp.hphlhulahhShhGhlppptThtsFaFt.tp.u.t.-.hhL.hs.ststth..sttp......ahhstSPcWphs.shl.uu.Lot.lhus.p.t..P.h.hsptsl.s.upsh.sh.o...s.t..s...l..th..p.h.hstthh.phh.sGlhstupttthpt.hstht.hhpttltthhhtss.h.....t..th..hpPa.stpas..G.oh.s..............................................................	0	0	0	0
+4429	PF02454	Sigma_1s		Sigma 1s protein	Mian N, Bateman A	anon	Pfam-B_2133 (release 5.4)	Family	The reoviral gene S1 encodes for haemagglutinin (sigma 1 protein), an outer capsid protein and a major factor in determining virus-host cell interactions. Sigma 1s is one of two translation products of the S1 gene.	20.10	20.10	21.00	29.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.45	0.71	-4.32	5	20	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	8	0	0	20	1	114.30	61	84.05	CHANGED	CQ+uLNpGSRRSR+RsKYTLIhSoGSl+DSMpQpNESSLLSKVGpsWLHQhVppNLQSPDWKALSEPSKQLSMDLIRVLPsWVsEW-sLRQDLQsYAhTpsISL...REWlLRN....sTLDH	...CQKGLNQGSRRSR+RLKYTLIlSSGSsRDSMMQTNESSLLSKVGhsWLHQSVMhNLQSPDWKALSEPSKQLSMDLIRVLPSWVlEWDNLRQDLQSYALoTsISL...REWILpN....VTLDH......................	1	0	0	0
+4430	PF03842	Silic_transp		Silicon transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	49.40	33.40	23.50	23.00	hmmbuild  -o /dev/null HMM SEED	513	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.80	0.70	-6.42	4	167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	79	0	7	165	0	287.70	62	98.66	CHANGED	hhoshssl+hhYShuLlIFSlIIVsALMFspsTKlApDspPhsALllMhhuIlWhSMlEGtQsShVGLPP.VD+sLYKESHPlTa+.suLuaKGDNLDRYLMGRQFMVlhlsFsINLCGuPL-su...-VLGLPpllppIFLsoGIAMILhsshIGQLTsQVNASHCMlDaINsaFhhFTLYssLlIEhoGVMHuSYLIQshhhhluGKPVpTNE.PRouhQshFFWGRVLhSLulLsFuLAVTlpALFsGpTTM...WphIPssVAllLFFlLMSlVGhLEGMQIAFFAVAKl.+pERGsp.Fu+KTCELLF+GpGcNLPGFMlGRQhTVshCFFllARVTTLDIEVGss-NIFGVSDGhQtFhNhGFhGAlITTILASIsWQLsASAFPlAFLsNPhsYIlLhluLhLEATGlCuGAWhLuhIpK+VstFphDEVYVGTPEE.RhutD+sDtphcts...tthhhGssh........................coasspppDhLc.........t.sup.cEttt..tu.s.cTcAL.chscpQ..-Ah-hhsups	......................................................................................................................................tst....-VLGhPshlp.lFLsh.GLuMIlFTChlGQLsoQVNAoHCMlDaINNYFALFTLYsAMslEFSGlMHuuYLIQ.lhutlSGKPI.SNE.P+sGhphhFFWuRVLMSlAILuFshAVslsALFsGpThh...asulsssluVhlFFhhMulVGhLEGMQIAFFAVAKLPtpERGouaFG+KTC-LLFcGNGpNLPGFMIGRQLTVVhSFFlVuulTuLsIpPGpGs.NIFGlSDGAQsFLNaGFpGAVITTILASIoWQLAASAFPlAFLNNPlTYlLLhlALhLEhTGlCuGAWV......................................................................................................................................................................................................	0	6	6	6
+4431	PF04801	Sin_N		Sin-like protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6302 (release 7.5)	Family	Family of higher eukaryotic proteins.  SIN was identified as a protein that interacts specifically with SXL (sex lethal) in a yeast two-hybrid assay.\	  The interaction is mediated by one of the SXL RNA binding domains [1].	20.00	20.00	20.60	20.60	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.46	0.70	-5.62	15	414	2009-09-10 16:59:54	2003-04-07 12:59:11	8	6	306	0	263	406	1	288.50	21	70.12	CHANGED	EED....DPVVpEIsVaLupoLs-..pLYlhQYPl+stttsaDssp....................h.ss+lKPpspclEh-hulDTpSpsYDt.KuE...h.hsG........psupcpsshpsthh-tpsFhSs+shsssscYAVGlhpsGElHLTPLpuIlQhRPShpahD.K..p-pcpKs....cpsup--s-..scp............p..c.hptloV+FuR...tsp+t+ptR.pohphhpph.u-EsWlchpaashp.sspsphc+ptLhupsssss........sshshSsp-YlshLhssstccphs........ssspcsLspppL+shPLh-.Ql+sLhpcu+..VhpFuplhpLl.................spss.....s-plLcsLppsAhLVpGsWVsKS-llasc...u.......tshh.A-shppARDalLapFops.ct.lpRppls...ssspLssc-s.....+-lLsphAp..sp....ss+sWclhhssDc.-F.........p..cas-lVp+..QchhWpupppcLcchh	......................................................................................................................................--....Dslltphslals.............s.tt........plalh..Q...YP..+.st..............s....h..pt......................................................ps+hKsppt.h..l..E.l-hsl.sp....s...t....as...hs..................................................................t.tpt..t.h.ppt.....hh............t.tts......s...s.tYh...h..uh.h......p......p....t...........p....l..HLsPl.p.ulhQhRPphpalD..t........ptp..tpt............ptt.tptttp..tpp.............................................t.hp.lp....h.p..ht.......p.......stpt.....t......t..t.t.....s...h..p..h.tp..E.Whphpaht.p..s...s......................hh............................................................h.......................................................................................................................................................................................................................................................................................................................................................................................................................................h..........................................................................................................	0	94	148	217
+4432	PF04954	SIP		Siderophore-interacting protein	Bateman A	anon	COG2375	Family	\N	26.30	26.30	26.60	27.10	24.30	25.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.58	0.71	-3.73	169	1985	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	1328	1	509	1471	82	120.80	30	41.36	CHANGED	schhLLsGD-TALPAlushLEpL...P.sssputshlEVssss-.p.slss........ssslplpWlhRsss............tsshLhp.slpshsh....................................................................ss......ssasW.lAuEusss.+slRcaLhp-tGls+p.plthsuYW+pG	..............................................................................................................................h...hLhluD-oulPAlsphL...EsL..............P.ss.spsp.sl.l.c.V.ss.ssc....p.....Lsp...................hssh.plpWlh+ssp.............tslss.slpp.hph...............................................................................s......................ss........shasW.lsGEupsl.+slR+hlptEhulspp.plpssuYW+t.................................................	0	125	323	436
+4433	PF02146	SIR2		Sir2 family	Mian N, Bateman A	anon	IPR003000	Family	This region is characteristic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organisation and DNA damage repair processes [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.21	0.71	-4.54	20	5869	2012-10-03 09:55:27	2003-04-07 12:59:11	12	37	3562	114	2282	5061	910	172.30	31	58.89	CHANGED	GAGISspuGIPDFRS.csGLas+hspcs..LssPpshhchsphhps...FYsht+chh....pspPsssHphlstLEcps.plhplhTQNIDsLcccAGsp..pllEhHGShspspCssCch.hstpplhpphchtp.s..............................pCspCGu...................................llKPDlVaFGEsLP.cphppshc.clpcsDlllVlGTSLpVhP	.......................................................................................................GAGlSs.p.....S..G..I.............P....sF.R......u...........t...s..G.......l.a........p........p........h........p...........t.................l.............s..s.c.......t.....h...h........p.......p...s...h...h.htp....................F..a.p.h.h.c........phh...............pspP......N.h..u...H.hhl..............A....p....L.............p.........c.........t.........t..............h........h.t....l..........lT.Q...........NlD......s.............L........H.......p.............c........A............G..sp.....................pll...ch.HGslhp..s.p....C.....h.....p....C.t......t...........h........s....h.....p.........h..........t...p....h....t...t..t....t...s......................................................................................pC...s...p...C..s.u.....................................................................................................h..l+P.c.l..V........h..F......G.....E...........ls........t....h...p...p......s......h.............p...t............h.........p..........p...u.............D.........lh.lllG.TShtVhP.............................................................................................................	0	811	1362	1902
+4434	PF04247	SirB		Invasion gene expression up-regulator, SirB	Mifsud W	anon	COG3094	Family	SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown [1].	29.70	29.70	29.70	29.90	26.90	29.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.48	0.71	-4.39	63	976	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	953	0	140	446	33	123.40	43	97.35	CHANGED	h.YhslK+lHlshlslSlsLFllRhhhhhpsus.hhpp+h.....l+IsPHllDTlLLlSGlsLhhlh...phhPFss..sWLotKlhullsYIsLGhhAL..+ps+.....spth+hhA.FlsAlsshhhlstlAhoKt..sh..l	......a.hLhplHLlsluLSlsLhslRaahphppps.....ht.h.....t+a.....s+IlP......llDTlLLLSGIuLhhhs...phhPFostutWLTEKLhuVllYIlLGalAL..+pt+.....o...p..p..sRhhA.F.LA.LlsLhhIlKLAsTKhPlL.....................	0	28	71	108
+4435	PF01380	SIS		SIS domain	Bateman A	anon	Bateman A	Family	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.  Presumably the SIS domains bind to the end-product of the pathway.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.28	0.71	-4.54	45	30074	2012-10-02 15:05:26	2003-04-07 12:59:11	17	45	4875	210	6102	21679	8959	126.50	18	45.69	CHANGED	hltpsc.plhlhGtGsuht.suhththph.pplshhsshst.usp.....httt.hshlspsclllhlo..hsspstchhpsst.hsppps.sph..lsITspssusluppu...chhlhh.ss.ph.......hpshssphsshtslhht	..........................................................................h...ptp.plhhh.G.tG.s....o....hh...s....u.h....p....h....t..h....pl...p.......p...h.......u...h...h..s...s.....t....s..h...s..u....st....................h.tts......h....s.....h.....l...s......p....s.......s....l....l....l.s.lS.......tSG........p.....o........t........-........h.....lt.....s.....h.......p...h....s..+....p.......p........G....spl............lsl....o...s.......t...s...s..o....s.....l..s.....p.....u.........s..h...s.l...h..h....s.s..ch...........h.s.h..t..s..h.ss.phhhh.hh...h.................................................................	1	1857	3650	4961
+4436	PF05185	PRMT5	Skb1; 	PRMT5 arginine-N-methyltransferase	Wood V, Mistry J	anon	Pfam-B_4050 (release 7.7)	Family	The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase [3][4].  These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.61	0.70	-5.57	35	750	2012-10-10 17:06:42	2003-04-07 12:59:11	11	21	319	29	484	1612	79	345.80	25	63.15	CHANGED	-.hssWphWsslRphC.sap.spLpVuLcls..psl.Pst....p.lpRWhuEPlcslllssshFlsN..pp.GaPsLsKtpQplltpahphpssthlls........................................................t.sscpshss...Ylp....Yl+aLhpp........s......shsttcpht..sYpDhLQsPLQPLpDNL-StTYElFE+DslKYp.Y-cAIppALhDhssppctss.........................hllhVlGAGRGPLVcpsLpAuppss..s........plclaAlEKNPsAhlhLp.p+.phcp...W...ts+.VpllpsDMRpapsst.......................KsDllVSELLGSFGDNELSPECLDGhQ+.....aLpps.GISIPpuYoSY...................lsPIsuspLasc...........lpthpp................................ssshEpPYVVphpshthlusp.............................ppsapFpHPstp...............................p..tcNsRapslpFps.pp...cuhlH..........................GFuGYF-usLYpD........lpLSIpPs..........................................s...+oss.MhSWFPlaFPLcpPlhlpcss.........plplphWRpss..spKVWYEWslss	......................................................................................................................................................................................t............................................................................................................................................................................................................................................................................................................................................................................................................................................hllhslGuGpG.Ls.h.uhpAu...........................thcl.Y.AV.E.t...s...s.....A...h.t.h.p.th...p...t.p.t.....h.............ssp...l.pl.....l...p...u...ch.cch....p...h.P.-...................................................................psDlllSEh.h..G..s..h.h....N..E..h...s.E.....s....l.....ut.....p.+...........aL.+ss...G....l....hPsp..hsha.....................luP.h.s.s..t..p....l..a.p.c....................hh.s.h.tt...................................................t.hcps.h...l.....s....p....hp.sh....h.....l.uts..................................................p..s.h.s.F.p..cspts....................................................................tp..p.p.h..pt....t..h.p.F..t....h...pp.........su.hlH................................GhusaF-...s....h...h...h.t.s............................lh..L.S.h..t.Pp.................................................................p........shhpWh...hhh.l....p..pP.l...lptsp............pl..p..h.....h................................s............................................................................................................................................	0	182	271	391
+4437	PF01202	SKI		Shikimate kinase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.08	0.71	-4.36	98	7157	2012-10-05 12:31:08	2003-04-07 12:59:11	17	51	4272	70	1785	5455	2766	155.30	27	64.96	CHANGED	hGuGKoTlG+hLActLshpFlDs.Dp.h..I....EppsG....hslspIFp.pc.GEssFRchEpcs...l..pclhppp.....shVluTGGG..slhppc...spphLp.............ppGh.llaLcssh-tlhpRl..p.pcpp....R...PlL.psps.........p.h....h..chlh.pRpslYpc..h.....u......s.h..h.hss.spps..............pplsppllptlp	...............................GuGKoTlGp.t.L.....Ap..p.L........s.....h.p.........Fl....D..........s...D.p..h.........l.............p.pps.s.......tsl...u..p..l..h.s...h.p....G...E...s...s....F......R......p...h.E..p.....p....s........l........p.c....l....t..pp....................ssVl..u....s.......G..G...G......s..........s...hp.cp..........sR.s..hLc.......................................tp..sh....s..l.a...L..c..s.s..h...-..h..lh.pRl....p..tcps............R......Phh...psps...........................ph......h...chlt.....p.Rp..s.h.Ycc....h.....s..........t.h..h..l.ss...spts.............ptlspplht...t.................................................................................................................................................	1	506	1065	1476
+4438	PF02731	SKIP_SNW		SKIP/SNW domain	LOAD	anon	LOAD	Family	This domain is found in chromatin proteins.	25.00	25.00	30.50	30.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.14	0.71	-4.77	28	359	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	296	0	242	348	3	154.70	53	31.04	CHANGED	spaI+YTsssp.ss.t........pp......RII+hsppp.....pDPL-P..P+F.K.+K+lspsssSPPsPlL+......SP......sRKLTtEDppcWcIPPslSNWKNsKGYTIsLDKRluADGRu..Lpcsp.....lN.-+FApLo-AL.hA-+pAREElctRschp+phs.+EppcKE-+LRpLAp+ARp-R	.......................................s.palR.YTPupQs.sshsp.........tpp........RlI+hVEhQ.....pDPhEP..P+F.K...pKKlPR.G..PPS......P..Ps....PVhH..........SP..sRKl.Tsc-Qpc....WKIPPsISNWKNsKGYTIPLDKRLAADGRG..LQsVp................IN.-pFAcLuEALahADR+AREtVchRAphp++hApKEKppKE-cLRplAQ+ARpcR...................................	0	80	132	199
+4439	PF03217	SLAP		Bacterial surface layer protein	Mifsud W	anon	Pfam-B_2530 (release 6.5)	Family	\N	27.00	15.20	27.10	15.20	26.80	15.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-11.08	0.71	-3.93	27	528	2009-09-14 12:59:11	2003-04-07 12:59:11	9	28	47	0	108	469	0	105.10	28	27.52	CHANGED	oK......slMHsAYsYs.psG.c...+l...ss...h.hpshs....sls...h.hs........s..sts..I.sGKpYY......+Vup.s.....cYItAuNlDGTpRh...LK+NAYVYss.supR....ssph.hh+KGoplsTYGushplhNGK.pYY+IGt..s..tpYVKsuNF	......................................................................lh+suhhYs.psG.p...ph......st.........h...hhthp....plp....h..h................s..hhp.....I...sup...pa..Y......plsps......pYl.....pus.N..l...s...u...s.p+p...................lp+.NAYlYppss.p+...............ttp....h....hlpK..Gpplp..s..a..Gs..p.h...h...t..Gc.pY.Yplst....s.....pal+s.s..............................................	0	10	10	24
+4440	PF03843	Slp		Outer membrane lipoprotein Slp family	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.60	20.60	21.00	34.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.70	0.71	-5.24	38	1178	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	813	0	129	486	27	159.70	46	83.93	CHANGED	LuGCso.lPptl..tspsssh.shsplpssssshhGppVRaGGhIlslcN.ppspTplEllshPLss.su+P.phs..ppopGRFlAphsGFLDPssatpGRhlTllGslpGhcpsplGchsYpaPVlpspsh+lWp....htpph.hss.......a...s.ah..ashh.....hWt	..............................LuuCso..lP..psI.t.s.ssP.ss.QpshVtVhstPtLYl..........GQpARFGGKV..lsVpN.tpscTcLEIAslPLDS..uA+P.sls..ps..spGRlh.AchsGF.LDPVsa.RGphVTVlGsIsGs...s.GK.IGpsPY.pFhlhps...pGa+hWH......Lppp.V.hssp..........sa..h.Y...G..u.....h.........GaG....u....Y................................	0	32	65	98
+4441	PF01464	SLT		Transglycosylase SLT domain	Bateman A	anon	Prodom_3175 (release 99.1)	Family	This family is distantly related to Pfam:PF00062. Members are found in phages, type II, type III and type IV secretion systems (reviewed in [4]).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.54	0.71	-4.61	39	14235	2012-10-03 00:09:25	2003-04-07 12:59:11	15	167	3793	20	3295	11652	3304	115.80	22	28.70	CHANGED	shhttstpphslpstllhAlstpESsasPpAhS......tss.......................uhGLMQlhssTspthth...........shsphhcPppslpsGspaLp....phhpphst.......shhhuluAYNuGhuphtchhptttptstphhh	.............................................................h......ttthtl.s...t.h...lh.ul.h.htE...S....s......a......s.........s...p...A....h......S................sss........................................................................................AhG..LMQ.....l..h...s...s.T..u..p.p..hs.......................................sh.s...ph.h.-P.t...p....s..l.ps....G.s...p.....Y...Lp..........th..h..p..p..hst.......................shhhs.luA.Y.N..u.G....u...p..h.phht...........h....................................................................	1	900	1993	2657
+4442	PF02258	SLT_beta		Shiga-like toxin beta subunit	Bateman A, Mian N	anon	Pfam-B_3684 (release 5.2)	Domain	This family represents the B subunit of shiga-like toxin (SLT or verotoxin) produced by some strains of E.coli associated with hemorrhagic colitis and hemolytic uremic syndrome. SLT's are  composed of one enzymatic A subunit and five cell binding B subunits.	21.10	21.10	21.20	21.50	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.44	0.72	-4.14	2	261	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	133	146	1	142	0	67.60	81	78.02	CHANGED	As.DCspGKlEaoKYN-DDTFTVKVssKEhaTsRWNLQsLL.SAQlTGMTVTIKossCcsGuGFuEV.Fp	...................M.AADCAKGKIEFSKYNEDDTFT...VKVs..GKEY.WTSRWNLQPLLQSAQLTGMTVTIKSSTC-SGS.GFAEVQFN....	0	0	0	0
+4443	PF04102	SlyX		SlyX	Bateman A	anon	COG2900	Family	The SlyX protein has no known function.  It is short less than 80 amino acids and is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C-terminus. The protein may be a coiled-coil structure.	30.00	30.00	30.00	30.20	29.60	28.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.43	0.72	-3.60	114	1397	2009-09-11 12:49:59	2003-04-07 12:59:11	7	3	1387	1	285	730	213	67.60	42	92.66	CHANGED	plppRls-LEh+luFQEcsl-pLNpslscQppplccLpcplphLtp+lcshp.sst...ustsc-...sPPPHY	............hEtRlsELEs+lAFQE.TIEELNtslstpphphs+LpcpL+hLscKlcs...t....p...sSsh......As.pu-E..........TPPPHY..............	0	67	152	221
+4445	PF02481	DNA_processg_A	SMF; 	DNA recombination-mediator protein A	Mian N, Bateman A	anon	Pfam-B_2252 (release 5.4)	Family	The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation [1]. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyse the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [2].	29.60	29.60	29.70	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.27	0.70	-5.44	97	4687	2012-10-01 21:16:48	2003-04-07 12:59:11	10	17	4194	1	1010	3571	633	204.40	38	60.24	CHANGED	t.hppts...h.phls.ht-spYPptLcp.l................c...sP.hlLah+G..........shshL....t...slAlVGoRpsoshGtphspplsppLup.t.....uh..slVSGlAhGIDstAHpuAL.....ptt........GtTlAVLusGl..-hh....YPppNppLhpcIhp..p.GhllSE.....assssp.PpptpFspRNRIIuGLopullVlEAsh+SGoLlTAchAhc.u....RcVaA.l....PGsltsspupGsppL....IppG.Atllps	......................................................................................h...t.th.phls.ht-ttYP..h.Lpp...l...............................h...........s.sP.hlLahcG.........................shphLp.............p.plAlVGoRp..s...........ot....hG.p..........phsp.....pls.pp...Lup..p.......uh..s.llS.GLAhG..IDssAHpuAL......p.s.t..................GtTl.A.V.l.usGl..-..t.h....YP..pp.pppLtppIh.....ptGh..llS....E........a..s..s.....s.s..........Ph...t...hp..FPpRN....RIIuGLS.p.u.ll...Vl....EA...........s.......h....+.S...G.SL..ITA.chAh.EpG.......R.-VaA.l......PGsl.ts.s...hSpGsppLIcpG..Apllp.s................................................................	0	340	676	868
+4446	PF03467	Smg4_UPF3		Smg-4/UPF3 family	Bateman A	anon	Bateman A	Family	This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4 [1] and UPF3.	21.30	21.30	22.10	21.60	19.50	20.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.37	0.71	-4.27	6	408	2012-10-02 20:46:34	2003-04-07 12:59:11	10	11	263	3	260	394	1	159.80	33	36.82	CHANGED	ppsppctp.KVVlR+LPPsLTcc-hhpplps.Ls-c..................WshFchhsushSacsptYSpshlpFps.sD.lhEFpshFsGal....FlDsK......ssphhAlVEhAPa.QKlspssK..hKcDs+pGoI-pD...PcahcFhcplt..ctpsspsh..s-p.lc+.........tcstppht+h.sTPLl...-Yl+pK+sp+	......................................p......h...KlVlRRLPPsLTcpph.p.tl..t...s.......ls.tc......................................................p.ha...p.h.....hs.......s.ph...sh.h..........s.p..h.a..........S..............R...AYl.s..Fp..s...-.D...lh.Fpc..pacGal...................F.lDs+...............................G..p..h....sh......VEaAPa..Q+...h....sp...pp.............p+cD..s+.....tGTI...-pD...s-YhpFLEs..h....t.........p...p.p.....hts.......ct.lpc..........................pt.....ps.t.....p..h.....thh..sTPLl......pal+.p+ph........................................................................................	0	76	129	202
+4447	PF04927	SMP		Seed maturation protein	Kerrison ND	anon	Pfam-B_6221 (release 7.6)	Family	Plant seed maturation protein.	21.00	21.00	21.00	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.04	0.72	-4.01	37	316	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	61	0	192	289	0	59.60	34	56.79	CHANGED	tlplG-sL..........pAsuttsucKP...VstpDAAulpuAEs+ssGt...............tshPGGlAA..shpuAAshNtpsst	.................lphu-sh............p.sut....suc+P............lstpDAutlp.uAEs+spGt.................psts..GGl..AA..shpuAAshNtph..t...........	0	25	103	158
+4449	PF04355	SmpA_OmlA		SmpA / OmlA family	Kerrison ND	anon	COG2913	Family	Lipoprotein Bacterial outer membrane lipoprotein, possibly involved in in maintaining the structural integrity of the cell envelope [1].  Lipid attachment site  is a conserved N terminal cysteine residue.  Sometimes found adjacent to  the OmpA domain (Pfam:PF00691).	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.36	0.72	-4.36	146	2731	2012-10-01 23:09:26	2003-04-07 12:59:11	8	6	1710	10	507	1486	1060	70.60	29	49.17	CHANGED	GshlspptlsplpsG.Mo+pQVphlLGoPhhs.ssFsss.pW..Ylhphpps.....t.tt..........p..ppplslhF-ssshlpths	..........Gphlstsslppl+.......hG.Mo+pQVthlLG.sP...hhp...s......h...p...sp.....sW..Y..lhpppsu.....p.t...........................p...ppsltltFsssGhlps..s...........................................	0	102	248	380
+4450	PF01668	SmpB		SmpB protein	Bateman A	anon	Pfam-B_1766 (release 4.1)	Family	\N	20.20	20.20	23.20	25.90	19.70	18.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.11	0.72	-4.17	166	4544	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	4483	12	970	2590	1894	67.80	47	43.63	CHANGED	ph..l..ApN+KA+a-YtI.-paEAGlsLpGoEVKSlRs.G+sslp-uastl.csG....EhaLhssaIssY.ppush.h	............hl.ApNKKARH-YhI...-.paE..AGlsLpGoEVKSlRs...G+ssLpDuaspl..+s.G....Es..aLhssHIsPYppush.h........	0	339	651	828
+4451	PF01713	Smr		Smr domain	Bateman A	anon	[1]	Family	This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 Swiss:P23909 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2 Swiss:P94545 [1]. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity [2]. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.89	0.72	-3.79	123	5312	2009-11-23 09:46:11	2003-04-07 12:59:11	16	56	3968	8	1427	3901	1760	78.00	31	16.90	CHANGED	lDLHGhphc..-Ahptlpphlppshppsh...................pslh.lIpG+G......................sG.h......L+ptltpaL....hphphl.tht.s....t.G.usGshhVhl+	........................lDL+Gh.ph-..-Ah....p....tLt.p.a.lspuh.t.psh................................................................pplp.llHG+G........................su..h..........L+ptVt.paL.....tppppVhuap.A....ptG.GsGuhlVhl...........................	0	513	907	1211
+4452	PF00835	SNAP-25		SNAP-25 family	Bateman A	anon	Pfam-B_1606 (release 2.1)	Family	SNAP-25 (synaptosome-associated protein 25 kDa) proteins are components of SNARE complexes. Members of this family contain a cluster of cysteine residues that can be palmitoylated for membrane attachment [2].	21.20	21.20	21.50	21.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.32	0.72	-3.19	13	273	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	105	20	132	235	0	55.90	41	26.35	CHANGED	PhNK....hps.c.ttstppsW+sNsD......GtVlssQP.tRVhD.tpssh.....sspuGYI..pRI.TNDA	..................PCN+....h+s.c...uacpsWusNpD.........GtVVus..Q....P...u.R.Vsc.pppph........usSGGaI..pRl.TNDA..........	0	27	39	81
+4453	PF00565	SNase		Staphylococcal nuclease homologue	SMART	anon	Alignment kindly provided by SMART	Domain	Present in all three domains of cellular life. Four copies in the transcriptional coactivator p100: these, however, appear to lack the active site residues of Staphylococcal nuclease. Positions 14 (Asp-21), 34 (Arg-35), 39 (Asp-40), 42 (Glu-43) and 110 (Arg-87) [SNase numbering in parentheses] are thought to be involved in substrate-binding and catalysis.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.32	0.72	-3.79	18	4232	2009-01-15 18:05:59	2003-04-07 12:59:11	12	46	2100	210	1727	3872	2427	105.40	24	47.39	CHANGED	+lRLsulDsPEosc..t..................psaGpcApcah+chlhtpclhlh.hsp.....D+YGRhLuhVahs.........spslNttLl+pGhAhsht.hYss..p.tppsphhpsEpcA+cc+hGlWup	........................................................................lRLhsl-..s..P...E...ht.............................................................ps.a....G..pc......A..p...p.h..h.c...ph...l..h....s.....c...p..l......p...h.t.h..sp..................D..c......a......G.....R.h...l.....uh.l.a.hs..........................................sps..l..sptl..VcpG..h.......Ahs........hp....h..............h......s..................................t......h......................p..........t.......h..h..pspppA+p.p.+hGlWp..................................................	0	583	1042	1458
+4454	PF00209	SNF		Sodium:neurotransmitter symporter family	Finn RD	anon	Prosite	Family	\N	19.70	19.70	19.70	19.70	19.40	19.50	hmmbuild  -o /dev/null HMM SEED	523	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.89	0.70	-6.03	15	11073	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	2324	84	3409	8360	1447	275.40	18	89.59	CHANGED	R-sWssKh-FlLSslGauVGLGNVWRFPYLCYKNGGGAFLIPYhlhLlhsGIPLFFLEluLGQasppGulslWt+ICPlFcGlGYAshlIshalslYYsVIlAWAlaYLasSFTssLPWspC......spsWNTscCh-.h..psts.............t..sho......t.SPstEFWcRpVLplo..........sGIpchGsl+WpLsLCLlluWlllYFslWKGVKooGKVVYFTATFPYllLhlLLlRGlTLPGAhcGIpaYLpPcap+Lt-PpVWlDAATQIFFSLGlGhGsLlAhuSYNKacNNCYRDullluhlNusTSFlAGFVIFSlLGFMApcpGls...........................................Iu-VAcs.....................GPGLAFIAYPcAlThhPhSPhWulLFFhMLlhLGLDSpFsslEullTullDpaPhhh+...+RElhshhlslhsaLlGLhhl.TcGGhYlhpLFDpYuAo.hsLLhlshhEsluluWlYGss+Fhc-Ip-MlGaRPshaa+hCWpFloPslhlslhlhSllpa..pPLsYss.Ys..........YPsW.u.ulGWhhALSShlslPlahlh+lhpt	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hh...................................................................................................................................................	2	1079	1659	2764
+4455	PF00176	SNF2_N		SNF2 family N-terminal domain	Sonnhammer ELL	anon	Published_alignment	Family	This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null --hand HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.00	0.70	-5.62	28	15349	2012-10-05 12:31:08	2003-04-07 12:59:11	18	509	4016	6	7427	19108	4238	288.60	21	25.86	CHANGED	aQhcGlpWhhphh................................................................................................................psthuGILADEMGLGK..............TlQsIullt......................hLtcttphh..................tP...................................................................................................................................................................................................................................................................................................tLllsPt.ShlpsWhsEhp+as.s.sl..pslsatGsp................................................................p.hhphtphhtshsVllToY-hlh......................+phshlpp..hc..WphlllDEuHpl...K........NspSpltpslpp.lp..sppRllLTGTPlQN....sLtElauLlsFlhPshas.........shc..sFcphh.....tts....................ptptspcthppLppllps......................hlLRRhK..s-l..pcs.....LPsKpcpllhsphoshQpchYp............phhppschhhstss................................................thpphhshlhpL+KhsNHPhLh	..................................................................................................................................................................................................................................................................................................................................................aQ..uh.t.ah................................................................................................................................................................................................................................................................t......th.s.s.lL....A..D..-......M....G.........LGK.............................T....l..p....s..l..s..h.lt...................................h.h.p..t...t..t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hLl.l..s......Pt.....o...............l....l....t....p....W....t....p...........E....h...p....c....a...h....................p.l.............ph.h....h...h....p....u....sp..........................................................................................................................................................................t..........t...............t...........h.......t.......p.........h......s.......l....l.....l...s...o....Y.phht...............................................................................................................................p....p....h.....p...h....ltp............hp..........a..p...h..l....l..l...D...E........u.Hp.l..........K.....................................N...t..p....o....p......h......h...p.....s..l.....p....p...lp..................spp...+.......l.......h.....L.................T..........G.....T...P..l....p...N.............................sl.t..E..L..a.....u...l..h....p....a.....l..........P..s..h..hs................................................shp.....pF...p.p..h.h.................................................................................................t.......t....t...h...p...p...L....p....p.....h...l...p...s.........................................................................................h.h..l..R..R..h.+..........ppl...........p..............................L..P.........+...............................p...................h......h..h....h..t...h....s..t..............p...p......t....h...Yp.................................................................th.h.t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2588	4337	6155
+4456	PF04855	SNF5		SNF5 / SMARCB1 / INI1	Kerrison ND	anon	Pfam-B_6054 (release 7.6)	Family	SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes  characterised so far [1].  This family consists of the conserved region of SNF5, including a direct repeat motif.  SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF  complex [2]. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs) [3].	21.80	21.80	22.00	21.90	20.30	20.80	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.66	0.70	-4.91	25	526	2009-01-15 18:05:59	2003-04-07 12:59:11	7	15	262	0	346	474	0	197.40	33	41.27	CHANGED	ppApp..........tsLVPIRLDl-h.................................-th+LRDTFhWNlsEplloP-tFAphlscDLclPsss...hhppIussIppQlc-Yts.........................................s.ht.p.....................................................................................-hRllIcLsIslupppLhDpFEWDlss.sssoPE-FApphssDLGLuGEFssAIAHuI+EQl.hhpKplh......................Gashsupslt-s-hctth.hss..................hsshhp.spptscpasPhlppLocsElE+pEt-+-Rph....R	.................................................................................................................t..sp..c.LVPIRLDh-h.......................................ss..+lRDsFh..WNhp........-.......ph.hos-.....FAph..hscDLc...L.......ss...............hhstIsptIcpQ.lppa.s...................................................................................................................................................................................................................................................................................................s-.Rll.l.pLslpls.ph.....hhDpFEW-hsp....tssPE......pFAhphst-LuLs.G.EFsssIAauI+tpl.h.h.p+...........................sh.h.st...tsh.s.p........................................................h...s.t.scpapPhl..LoptEhE+p.tcppRp.R.................................................................................	0	105	189	289
+4457	PF01174	SNO	UPF0030; 	SNO glutamine amidotransferase family	Belitsky B, Finn RD, Bateman A	anon	Prosite	Family	This family and its amidotransferase domain was first described in [1]. It is predicted that members of this family are involved in the pyridoxine biosynthetic pathway, based on the proximity and co-regulation of the corresponding genes and physical interaction between the members of Pfam:PF01174 and Pfam:PF01680 [2].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.28	0.71	-4.67	4	1876	2012-10-03 00:28:14	2003-04-07 12:59:11	14	6	1744	30	575	2672	2181	181.00	43	94.15	CHANGED	VLALQGAhhEHhctlc+ChsEs..........hsVKcsEpLspsDALIIPGGESTuMuhlhc+hGhh.sLhEFl+NspKshaGTCAGLIhLSpplusp...lhpLsLLcVsV+RNAFGRQspSFppch-Fpshh...psFsusFIRAPVI-clLss-sVplLh-hs....G..clVsAt.Qs.phLusSFHPELuEsshRhacaFlcphVp	.................................................VLALQGuhtEH..hp....h....l..c....p.h..G..s...cs...........................htV..+..p.hc.....c..L......p....p........l...D....GLIlPG..G.........E......S....T..T........h.s....+....L............h....c..p.......h....s....h.hpsl.....+.ph.lp.....s....................G....h..P...laGTCAGh.....I.l.L.......A.c....c.....l..t.st...............pp.....h.....L.....u.......t.......h..........D.........l.....s.........V.........c...R.............N..........A............F.........G............R.............Q.......l............-............S........F..........c......s..c........l..c........h....p..G..lu.........................t.s..h.......u....V.......F...I...R......A..P....h....lp.p........V.........G...................p....s......V...c...l..L...u.p.hs.........................s.....c.I.V...A..s+....Qs...shL.usSFHPE..L.....T..s....D...hR.lHpa.Flphh..t...........................................................................................................................	2	210	383	500
+4458	PF00080	Sod_Cu	sodcu; 	Copper/zinc superoxide dismutase (SODC)	Eddy SR	anon	Overington and HMM_iterative_training	Domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen.  Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding  family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	21.00	21.00	21.00	21.30	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.28	0.71	-4.04	127	3852	2009-09-11 05:27:43	2003-04-07 12:59:11	15	29	2380	488	1163	3237	322	143.20	32	72.64	CHANGED	Asshlpst...................ssp....ltGslphppss..ss......lplpsplpG...L.sP.........................G..hHGhHlHchGcs..sss..........stSAGuHa....NPts..tp..H.Gts..sst.................tHsGDLsNl..hs.sssGsu..phs..hhss.hl....sL.s.....sll....G.+ulVlHsstDDh...................popssGsuGsRlAC.GlI	............................................h...................tsp.......shGslph...ppp...s..ts.........lpl.ssp...l...p.G....L..ss..........................G.....HGFHlHp......h.Gs.....s...sss..............s.t.SA.......G.sH.a......sPts.....tp........H.suP....stt...............................tHhGDLssl..........hs...s....scG.p.A......phs...lhss..pl.........tlps.p.....slh.......G..+ulllHsssDshs.........................st.s.h..Gsu.GsRhACGlI................................................................................	0	373	655	952
+4459	PF00081	Sod_Fe_N	sodfe; 	Iron/manganese superoxide dismutases, alpha-hairpin domain	Eddy SR, Griffiths-Jones SR	anon	Overington and HMM_iterative_training	Domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen.  Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin.  A small fragment of YTRE_LEPBI matches well - sequencing error?	21.10	21.10	21.10	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.85	0.72	-3.72	25	8157	2009-01-15 18:05:59	2003-04-07 12:59:11	17	14	5135	325	1451	5799	936	79.40	42	40.82	CHANGED	sapLPsLPYsYsALEPHIScEThEhHHsKHHpsYVsN.LNshl-sh.-hspc...shEpllhp......shpsultNN.huGHhNHolaWpslu	...........................apLPtLP.Y..........s.h.s.A.L...c.P.a.lstcThchHHsK.HHp....T..........YVsNlNsul...c...st...p.....h...t.sp..........sl..E.c.l.lhp................................shpsu....l....h.NNuGG....HhNH.olFWcsLt..................................	0	485	915	1223
+4460	PF02777	Sod_Fe_C	sodfe_C; 	Iron/manganese superoxide dismutases, C-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington and HMM_iterative_training	Domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.	20.90	20.90	21.10	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.56	0.72	-4.20	27	8609	2009-01-15 18:05:59	2003-04-07 12:59:11	13	16	5213	325	1661	6184	1017	97.60	44	50.45	CHANGED	G.E.Ps...GpLucAIscsFGSa-pFKppFspuAsuh.GSGWuWLVhc...sspLplhsssNtsss.hspG..hsPLLslDVWEHAYYlcYpNtRP-YlcsFW.slVNW-.sscca	.................................................Pp..GcLtsAI.cpsF.G...S...a-...p.FKp...p.F.s.s..AA.s..s.p.F......G.S.GWuWLV.......h.......s........................................s...............G......+..L.tl...s.s.TsNpssP...l.......s........p..........s.............t........h........PlLsl.DVW.E..HAYYl...........p.Y........p.......N.h......R....sc........Ylpsaa.sl.l.NWp.stp............................................	0	546	1040	1403
+4461	PF03002	Somatostatin		Somatostatin/Cortistatin family	Bateman A	anon	Pfam-B_1891 (release 6.4)	Family	Members of this family are hormones. Somatostatin inhibits the release of somatotropin. Cortistatin is a peptide that is related to the Somatostatins that is found to depresses neuronal electrical activity but, unlike somatostatin, induces low-frequency waves in the cerebral cortex and antagonises the effects of acetylcholine on hippocampal and cortical measures of excitability [1].	20.30	20.30	20.40	22.50	18.00	19.50	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.11	0.72	-5.88	0.72	-4.26	5	165	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	79	0	56	144	0	17.70	81	16.29	CHANGED	+-RKAGCKNFFWKoFTSC	....RERKAGCKNFFWKTFTSC	0	2	9	24
+4462	PF01680	SOR_SNZ	UPF0019; 	SOR/SNZ family	Belitsky B, Bateman A	anon	Pfam-B_2034 (release 4.1)	Family	Members of this family are enzymes involved in a new pathway of pyridoxine/pyridoxal 5-phosphate biosynthesis [1]. This family was formerly known as UPF0019.	20.40	20.40	20.40	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.37	0.70	-4.73	10	1980	2012-10-03 05:58:16	2003-04-07 12:59:11	12	7	1849	59	591	1309	540	205.00	67	69.72	CHANGED	pGotplK+GhApMLKGGVIMDVVNsEQA+IAE-AGAsAVMALERVPADIRAsGGVARMSDPphIcEIhsAVSIPVMAKsRIGHFVEAQILEAlGVDYIDESEVLTPAD.paHI-KcKFsVPFVCGARNLGEALRRIsEGAAMIRTKGEAGTGsVVEAVRHMRtlsu-IRclpsh.oEDELassAKcltuPY.ELlppltctG+LPVVNFAA	.............................pss.clK+GhApMLK..........GGVIMDVsss.EQ.................A........+IAE-AGAsAVMALERVPA.DIRAsG..GVuR.MSDPc.hI....cE....Ihp....AVSIPVMAKsRI.GHFVEAQlLEAlG..VDYIDESEVLTPAD-ta.HlcKppFpVPFVCGA+.sLGE...ALRRI.uEGAAMIRTKG...E.s.GTGslVEAVRHMRplsuEI++....l...p..sh..........s...........-....D....E....L.hshAK.-LtAPY.ELlpp.ltcp.G+LPVVNFAA...........................................................	1	227	402	516
+4463	PF02208	Sorb		Sorbin homologous domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	21.10	21.10	21.80	23.60	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.52	0.72	-4.59	3	265	2009-09-11 11:43:11	2003-04-07 12:59:11	11	12	39	0	84	262	1	46.10	56	5.58	CHANGED	lKAsp..u.sshDEsGIPL...pTVDRPKDWYKTMFKQIHMVHKPs..sD	..........lKu.sph.uhGssDEsGIPl...poV..-RPKDWYKTMFKQIHhlp+..s.............	0	6	14	35
+4464	PF04203	Sortase		Sortase family	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The founder member of this family is S.aureus sortase,  a transpeptidase that attaches surface proteins by the  threonine of an LPXTG motif to the cell wall [1]. 	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.44	0.71	-4.54	138	4873	2009-01-15 18:05:59	2003-04-07 12:59:11	8	19	1737	74	783	3560	293	135.30	24	51.42	CHANGED	lpIPsls..lsh...s.lhp....s.....ss........tpsht.....Gsuahps.....ss...s.........Gt..ps.sslluGH....p.........sshFtpL.pcl.......c.tGDtlhlps................tsphh.pYc.......Vpsht.............l.....ss..ph......ph.....hs............pts...............pphlTLlTCs....sh.......................sspRhlVhuchs	................................................................................lpIPpls.......ls.h...P.lhp.......G...................ss.........ppsLtp............Gsuahcs.............sshs................Gt...ps....ss..llsG.H.........c.....hsssthF.s.s..L.p.ch.............................c.pGctlh.lps....................................tschh...sYc...............lpp.h.p........................................h.l.........pss....ch.......................ph.............lp.............................pts........................................cchlTLlTCs...sh..................sscRllVpuch...................................	0	283	543	695
+4465	PF04832	SOUL		SOUL heme-binding protein	Mifsud W	anon	Pfam-B_3872 (release 7.6)	Family	This family represents a group of putative heme-binding proteins [1]. Our family includes archaeal and bacterial homologues.	21.20	21.20	21.20	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.04	0.71	-4.74	71	715	2012-10-02 11:08:51	2003-04-07 12:59:11	7	16	287	15	420	683	1151	165.80	25	74.09	CHANGED	shEpPsYpVlpp.sss.......aElRcYsstlhA.........pspsp.ss.hcpu.sspuFphLssYI....hGp.Nps.....ppcIsMTuPVhpps..........................ttts.......................paphpFhh.Pupas.hps...hPtPsDs.plplpch.PupphAslpFSGhss-ppltppttpLpphLpppu...hp.....stu........sshhAtY...ssP.hs.shhRR.NElhl.lp	..................................................s..-ps.apllpp..tsp..........aE.lRpYt..s.h.hhs.................................ps.p..h...p......t.....hptu..hppu............F.tp.LhpYI........tGp..Npt..........ttcl.s.M.TsPVhpph.........................ps........................tps.....................phslpFhl..Psp.....a....p.........ps..........sPtP.s..cs...p.........lp.lp.ch..ss.hph.h.l..h.pFu..................G..h...s...s...pp..s..htp..ptppLtptL.pps.s......ht...........ts..................hhhutYssP...h..h.Rp.NElhh...t......................................	0	183	274	351
+4466	PF04267	SoxD		Sarcosine oxidase, delta subunit family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+).  This enzyme catalyses the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2 [1,2].	20.10	20.10	22.40	23.60	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.99	0.72	-4.16	89	550	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	367	8	172	490	1589	83.10	43	76.88	CHANGED	lIsCPhCGs.R-cpEFsatG-Ac.lsRPss..sus.s-cpWt-YlahR-NPtGhatEhWhHstGCtpWhsssRDTlTaElhs..shhAtp	....lIpCPaCG..RsEpEFshuG-A+.lsRPts......sss.hoDc-Wt-YlFhRcNP+Gh+tEhWhHstGCpcWFsssRD.TVTcclhssapst.p..........	0	36	89	125
+4467	PF04268	SoxG		Sarcosine oxidase, gamma subunit family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+).  This enzyme catalyses the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2 [1,2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.88	0.71	-4.35	6	546	2012-10-01 23:12:28	2003-04-07 12:59:11	7	2	369	7	174	1588	3279	147.50	26	76.56	CHANGED	RAhPup..AhsAslppuluhsLPstsssluoss...olhWluPDcahlls...Eutss.hAsLspulus.hu.ollDlStuRshIcloGspActlLsKusuhDLpscAFsVGtAssThhu+stshlh....RTGsDsFcllVhRSFA-phWchLp-uuuE	....................................................................t........thhtshp.p.s.hGhp.l.P...s.t..s..s..s...spss.....tslhWlGPD..E..WLlhs.......sp.s..t......s......h......tt...t....l....t....p...s..l....s....s......ht......u......l..l..-l......S........s...u..p...s...s..lcl...o....G.sps....c.p.................lL.s...+.u.s.......s....l...D.....L....p...s........p......s...F...s...s......G.....p....s.s...p....T....h....h.....s...+..s...s...l...h....lh................+...s...u...s....c...s...a.clhlh..R..SFA..cahhphLtcAut.....................................................	1	36	91	126
+4468	PF03172	Sp100		Sp100 domain	Bateman A	anon	Pfam-B_3126 (release 6.5)	Domain	The function of this domain is unknown.  It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND domain Pfam:PF01342.	20.60	20.60	20.60	22.00	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.37	0.72	-4.06	11	240	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	40	0	80	238	0	98.90	43	21.23	CHANGED	phhhEslhp+.FKcpKl-IAsAIc+sFPFLEGLRD+shITc+MYcDs.-uCRNLVPVs+VlYslLocL...E+sFshohLpsLFScVNLccYPcLppIh+SFpssht..s	......t.h.-shh++.F+ppKlEIA.AIp+sFPFLcuLRD+shIo-chac-s.-uh+N.LVPVp+VlYslLopL...E+s...F...s...hshLcsLFSclNLccYPcLhpIh+SFppsh..t....................	0	5	8	16
+4469	PF03014	SP2		Structural protein 2	Griffiths-Jones SR	anon	Pfam-B_1375 (release 6.4)	Family	This family represents structural protein 2 of the hepatitis E virus. The high basic amino acid content of this protein has lead to  the suggestion of a role in viral genomic RNA encapsidation.	28.00	28.00	28.00	28.70	27.90	27.80	hmmbuild  -o /dev/null HMM SEED	620	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-13.12	0.70	-6.64	2	3837	2012-10-04 01:49:40	2003-04-07 12:59:11	9	3	32	8	0	1287	0	127.50	61	98.02	CHANGED	hhGsphsSQ..sLP.................AGuR.tQ..Rs.uutWpsQ.QRPpuA.......sGsAPLTssssAssTtsVPDVDptGAlLhRQYNLsTSPLs.ushuuTNhlLYAAPlsPLhPLQDGTsopIMuTEuSNYAQYRV.thTlRaRPlVPNAVGGauIShuaWPQTToTPTSlDMNSITSTDVRlllQPG.Au.LsIPpERLtY+NpGWRSVETsuVspE-ATSGhlMlClHGoPhNSYTNosYTGsLGhlDFAlcLphRNLoPGNTNsRVoRhpsTA.Hpl+tsssG.AplTTsAAsRFMtDl+a.hGTstsGElG+GIhhsLFNLADTlLGGLPopLlpuAuGQhhYuRPVssANGEPpVKLYhSVEsA.pDKsIhlPHDIDLGsSpVshQDYsNQH.pDRPoPuPAPpRshusLRusDVLhlo.....lTsAE.....hsQshaGuuo.......ThhhhNlhTGspAsApSlDWoKsTlDGh.lpTlpt.Sto..FhsLPhhGK.uhW..GsptAGY.YpYNoTtp-.I.hlpN..GppVsh.sYTs.LGt..oshShlh.ltPhpA.......sD.P..httHThsD.CspChsLGLpsCshQu...pssEhpRLh.+lu+Th.S	.......................................................................................................................................................................................................................................................................................PVNSYTNTPYTGA......LGLLDFALELEFRNLTPGNTNTR.VSRY...oS.oARH+LRRGADGTAEL...T.TTAATRFMKDLHF...TGTNG.VGEVGRGIALTL..FNLADTLLGGLP..............................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+4470	PF02090	SPAM		Salmonella surface presentation of antigen gene type M protein	Mian N, Bateman A	anon	IPR002954	Family	\N	25.00	25.00	25.80	25.60	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.87	0.71	-4.21	4	199	2009-09-11 15:23:32	2003-04-07 12:59:11	10	1	185	0	4	50	0	140.00	66	98.38	CHANGED	MHSLTRIKVLQRRCTVFHSQCESILLRYQDEDRtLQAEEEAIlEQIAGLKLLLDTLRAENRQLSREEIYSLLRKQSIVRRQIKDLELQITQIQEKRsELEKKREEFQEKSKYWLRKEGNYQRWIlRQKRhYIQREIQQEEAESEEII	.................MHSLoRIKVLQRRCTVFHSQCESILLRYQDEDRtLQAEEEAIlEQIAGLKLLLDTLRAENRQLSREEIYoLLRKQSIVRRQIKDLELQIlQIQEKRsELEKKREEFQcKSKYWLRKEGNYQRWIIRQKRpYIQREIQQEEAESEEII......	0	2	2	3
+4471	PF02510	SPAN		Surface presentation of antigens protein	Mian N, Bateman A	anon	Pfam-B_1678 (release 5.4)	Family	Surface presentation of antigens protein (SPAN), also know as invasion protein invJ, is a Salmonella secretory pathway protein involved in presentation of determinants required for mammalian host cell invasion. 	20.10	20.10	20.90	20.60	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.97	0.70	-5.39	2	189	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	170	0	7	96	0	271.70	61	90.70	CHANGED	MGDVSuVSSStNhLLPQQDEVuGLSEALKKAlEKHKTEY.sDKKDREYGDoFVMHKETALPVLLsAhRpGAPAKSEpHsGpsSGLpHNsKG-FRIAEKLLKVTuEKSVsLlus.tKsDKoAALLSS+NhQlttVuuKKLSsDLKA...VSELADNshtloDDNlKA..sDpKsIsGEGlRKEGs.LAtDVAsSRhAAsNTuKuDDKDHKKIKEssQLPlQPTTIADLSQLSGGDEpMPLAApSK.hMThFPhADGVKt-DsSLTYRFQRWGNDYSVNIQARQsGEFSLlPSNTQVEHRLHDQWQNGNPQRWHLhRDDQQNPQQQQHtQpSGEEDDA	......................................................................................................................................................MGDVSAVSSSGNILLPQQDEVGGLSEALKKAVEKHKTEYSscKKDRDYGDAFVMHKETALPVLLAAWRHGA.AKSEHHNGNVSGLHHNGKGELRIAEKLLKVTAEKSVGLISAEAKVDKSAALLSsKNRPLEuVSGKKLSADLKAVESVSEVsDNATGISDDNIKALPGDNKAIAGEGVRKEGA.......PLARDVAPARMAAANTGKP-DKDHKKVKDVSQLPLQPTTIADLSQLTGGDEKMPLAAQS..KPMMTIFPTADG.VKGEDS....S.LTYRFQRW..GNDYSVNI....QA.....R...QA.GEFSLIPSNTQVE...HRLHD.QWQN.GN.PQRWHLTRDDQQNPQQQQ.HRQQSGEEDDA..........	0	2	3	4
+4472	PF04573	SPC22		Signal peptidase subunit	Waterfield DI, Finn RD	anon	Pfam-B_4675 (release 7.5)	Family	Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals.  This family is common to yeast and mammals  [1,2].	25.00	25.00	30.20	25.20	24.00	24.40	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.14	0.71	-5.04	14	439	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	303	0	302	411	5	141.80	28	86.75	CHANGED	MpohlsRuNul.huaoLolhAhlshssahSsh.FpchpssssIpshc..hhl+slpcFs.sspc+sDhuhlTFDLssDLspLFNWNsKQLFlYLoAEYcTtpNt.lNQVVlWDKIIhcs-puplsh+shpoK...YhFaDsGsGL+Gt+NloLsLpWNVhPpsGhLshspus.GphshsFPspYp	....................................................ph..Rhpth.hs.h.h....s..h.hhh...hh....hhh..h.s.h....h........p..s......s..s.p..l.p..........................h..ph.p..ah.....h.tp...t...p-.s...lpFs.ls...........sD.......L...p.....s.........l.....Fs.WNsKQlFlYlsAcY........to.....t........p......s.........t.....h.......N.....pl.....slWDpIl...pt......-.p.......s.h...lthp.s.......psK............Y.hh.D...s..s.tl........tt.pshslplpasl.P.sGhl.hs.p...........................................................	0	87	158	247
+4473	PF05122	SpdB		Mobile element transfer protein	Yeats C	anon	Yeats C	Domain	This proteins are involved in transferring a group of integrating conjugative DNA elements, such as pSAM2 from Streptomyces ambofaciens ([1]). Their precise role is not known. 	25.00	25.00	53.50	53.30	19.80	17.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.77	0.72	-3.94	3	33	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	23	0	10	35	0	52.40	68	85.52	CHANGED	MRIGPVQIGTHRDRHGQTKHAAVCTNDGCGWSADYTSQSAAQLAARTHRCKVS	....RIGPVQVGTahDpR.G+pKHsAACTAPRCGFSADYsSRuAAELAARTHRC.Vp..	0	2	8	10
+4474	PF03771	SPDY	DUF317; 	Domain of unknown function (DUF317)	Yeats C	anon	Yeats C	Domain	This a sequence family found in a set of bacterial proteins with no known function. This domain is currently only found in streptomyces bacteria.\	     Most proteins contain two copies of this domain.	25.00	25.00	26.20	25.10	24.00	24.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.19	0.72	-4.48	16	112	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	16	0	67	132	0	64.50	25	43.21	CHANGED	hsSPDupstlpaps.........tsssssWpl.....hsssssststWpApFsspsPscLluuhssuL.ssssshpc	.......................SPDthhhlta.s.........sstsssWpl.....tsssssssstWtAsFsspTPs-llAuhssuL.sssts................	0	17	57	67
+4475	PF00435	Spectrin	spectrin; 	Spectrin repeat	Bateman A, Finn RD, Stabach P	anon	Pfam-B_1 (release 1.0)	Domain	Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure.  These include spectrin, alpha-actinin and dystrophin.  The sequence repeat used in this family is taken from the structural repeat in reference [2]. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in ultiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.14	0.72	-3.75	83	21182	2009-09-14 14:25:53	2003-04-07 12:59:11	16	452	349	133	9769	19145	10	103.80	17	36.64	CHANGED	pphppFtpcss-hppWlpcp.cthl..ssp-h.spclsslpsLhc...+Hcthcp-lss.ppsplpplp....phuppL.hspt...t.ss...pplpp+hpplsppWppLpphstpRcppLpp	............................................t..hppF...pphpp..h...t...sWlp........c.p.....c...t.............h...l.......p.s..p...s.....h.....u......p...s..h....p.....s....l..p.....t......hlc....................ca..c..s..h.p......p....-..l...p...........s...p..pspl.p.p.lp..............................ptup.pL....hppt................t.ps.....................ppl...p.pp...hpp........l......p.p...pW..p...p.L.pp.hht.p..RpppLt.........................................................	0	2238	2954	5943
+4476	PF01564	Spermine_synth		Spermine/spermidine synthase	Bateman A	anon	Pfam-B_798 (release 4.0)	Family	Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.43	0.70	-5.44	17	3831	2012-10-10 17:06:42	2003-04-07 12:59:11	12	30	2623	95	1322	3677	1590	224.20	28	64.46	CHANGED	hWFpEh.s.....................hss.uhsh+VcclLact+ScaQclhlaco...........psaGclLl............LDGslQhoEcDEahYpEhlsHlshhs+s.....NP++VLlIGGGD........................GGsLREllKHssV.............EclshV-IDptVI-hu+calPphuss......hpcs+lpl.hlsDGhpalpphps.....paDlIIsDsoD.PhGPucs.....LFpctaachhtcsLptsGlhssQu..cs.alphchhpslhpsh+psh...sthhhsslPTYssshhsahlsocp........ps	.............................................................................................................................................................................h....................................htht.p..lhptp.o..a.Qcl.l..h.cs.......................ta.Gphhh..........................LDG......h....l.....h..o......p.....t..DE....a....h.Y...pE......h....hs....H...ss..hh.s.cs..............p.s.+.+.VLl.lG...G.GD..............................................................G...u.s...l.R.E...l...h..+a.......s.l...............................................................................................c..p.ls...h..V..E...I....D.......t....t..Vlc.h..s....+....p....a...h..s.p.hsss...........................hcDs...Rhpl..hlsD..Gh.p..alpp.spp....................paD.....lI........I..s.....D......s......o.....D...P..........h....G.............s.ups............La..o.....p.t.FY.pt.s.tc.sLp.s.s.G.l..hls...Qs........tss.h..h..p.......p.....h..h.p.h...h.p.p.h.p..p........h.......F.............st........h.s.lPoa.s.t.hhhhhhtpt...........tshtt....................................................................	0	463	818	1110
+4477	PF02819	Toxin_9	spidertoxin; 	Spider toxin	Griffiths-Jones SR	anon	Homstrad	Family	This family of spider neurotoxins are thought to be calcium ion channel inhibitors.	21.30	21.30	21.50	21.70	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.11	0.72	-3.89	6	29	2012-10-01 22:06:18	2003-04-07 12:59:11	10	1	12	6	5	49	0	39.90	38	58.82	CHANGED	Chu.sYc+CshGtpPCCcsR.sCcCslhhsNCcCK..+hlhEhhGhu	...Chs.hhcpCshsppsCCcsp.sCpCshhssNCcCp..+hh..............	0	1	2	5
+4478	PF02513	Spin-Ssty		Spin/Ssty Family	Staub E, Mian N, Bateman A	anon	Staub E	Repeat	Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo [1]. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis  and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.	25.00	25.00	25.70	28.00	22.10	18.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.28	0.72	-4.40	27	646	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	56	6	298	766	0	48.10	42	57.44	CHANGED	VGppVpHhac-s..t.hspWcGhVLsQlPspsolaaIKY-sDsslYshpLh	..lG+pVpHsa--G.pt...shscW+GhVLsQVPspPolYaIKY-sDsslYsYpLh..........	0	15	29	99
+4479	PF05215	Spiralin		Spiralin	Moxon SJ	anon	Pfam-B_6625 (release 7.7)	Family	This family consists of Spiralin proteins found in spiroplasma bacteria. Spiroplasmas are helically shaped pathogenic bacteria related to the  mycoplasmas. The surface of spiroplasma bacteria is crowded with the  membrane-anchored lipoprotein spiralin whose structure and function are  unknown although its cellular function is thought to be a structural and  mechanical one rather than a catalytic one [1].	20.80	20.80	20.80	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.55	0.70	-5.25	4	22	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	13	0	0	21	2	211.00	67	98.10	CHANGED	K+LLSILAVFGVSAVGTTSVlACNKTESNNLSRVKTIAAPtTVAAtssppVTKtEIKsuL-sNVLKAVQGVVKTApAsDF.aEVYpDNcGpAL-TlNLcAGpV-VYVQITPAKDKTVVIGKoGYIKVTLPKt...hKsDISsVTVsEQTVtIKsusPpsVTKsELpAVNp.AsLApAVLsAIKsKsssstAS-FtITNNGstGsYSAsKsVEVTVKApDsSspIoGpFKFNAKVTAThs	KKLLSILAVFGVSAVGTTSVVACNK.TESNNLShVKTIAAPATVAstp........PKpVT+sEIKTALE....ANVLKAVQGVVKTATAA.DFQFDVYpssKGT.uLpTIsLEuGpV-VYVQITPAKDKTVVIGKoGYIKVTLPK....hKVDIpsVslspQhVtIKAucPKpVpKDELNAVNT.sTLApAVL-AIpphAPNAG..ASDFEITNNsstGsYpstK-VcVTVKAKs-SsNISGpFKhpAKVpAhh...........	0	0	0	0
+4480	PF03533	SPO11_like		SPO11 homologue	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.10	21.10	21.20	22.50	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.17	0.72	-4.08	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	23	0	15	36	0	42.20	74	10.96	CHANGED	AFAPMGPEASFFDVLDRHRASLLAuLRRGGGEPPuGGTRLASS	......AFAPMGPEASFF-VLDRHRtSLLAALRRGGtEPPuGGoRlASS....	0	1	2	3
+4481	PF05032	Spo12		Spo12 family	Wood V	anon	Pfam-B_51047 (release 7.6)	Family	This family of proteins includes Spo12 from S. cerevisiae Swiss:P17123. The Spo12 protein plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive [1]. Spo12 is a nuclear protein [2]. Spo12 is a component of the FEAR (Cdc fourteen early anaphase release) regulatory network, that promotes Cdc14 release from the nucleolus during early anaphase [3]. The FEAR network is comprised of the polo kinase Cdc5, the separase Esp1, the kinetochore-associated protein Slk19, and Spo12 [3].	20.50	20.50	21.10	21.30	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.40	0.72	-7.57	0.72	-4.33	9	136	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	117	0	96	116	0	34.20	45	21.64	CHANGED	ASPTDsLlSPCSpKLs-HKuKhFtt+spPspLths	..SPSDslhSPCopKLsshKsKpat.pt.ppsphhh...............	1	27	53	81
+4482	PF03907	Spo7		Spo7-like protein	Wood V, Bateman A	anon	Wood V	Family	S. cerevisiae Spo7 Swiss:P18410 has an unknown function, but has a role in formation of a spherical nucleus and meiotic division [1].	34.10	34.10	34.70	37.70	21.60	34.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.29	0.70	-4.72	9	132	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	128	0	99	124	0	205.40	40	52.65	CHANGED	SPsuhIFRNLLILE-sLRcQshp.+hh+hQaThFLohLhulssahhYtLYasscps....pG.......lhRhhLphsllhhhlTllLFHlSGpY+RTIVlPRRFhs.TNKGlRtFNlKLVKl+ssa.cchhD.lRhh.h.ls...la.hphhlhhutps..u.hhpFhpsspl+spsR...........................lGusDVKLlLsP+sFos-IREGWEIYRsEFWs+EusRRRcppp	...........................................SssstIYhNLLILEsuLRtQhlpLRtRRRpaThFLhlLshhluahsYt.Lahpscpsu...pG..................................hlchh.phsLhu.ullTslLhasoGpacRsItaPRRalssoN+GLRshNsKl.Vhl+ssWhpch.hshlta...............hphhh.....t.ts...u...tahps.s..pp..p................................................................................Gus.lKLlL.s+sFSsphREsW-.YRsEaWt+.EstRRt...h..........................	0	23	51	83
+4483	PF01052	SpoA	SPOA_protein;	Surface presentation of antigens (SPOA)	Finn RD, Bateman A	anon	Pfam-B_408 (release 3.0)	Family	This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, Pfam:PF02154.	23.00	23.00	23.30	23.20	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.01	0.72	-4.38	130	6032	2009-01-15 18:05:59	2003-04-07 12:59:11	15	12	2189	8	1289	3714	814	75.30	26	29.28	CHANGED	ltpplppsslplpshluctplslp-lhpLpsGcllsLsps.htctlplhl....ssphlhpGchs...thss....phulclpchhppp	............h..t.l.clslplssplGcsphslp-lLpLp.GsVltL-p...ss-...s..lc.l.h.l....suthlupGcls...slss....phul+lscllp..s.......	0	420	802	1028
+4484	PF05036	SPOR		Sporulation related domain	Bateman A	anon	COG3147	Domain	This 70 residue domain is composed of two 35 residue repeats found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM.  This domain is involved in binding peptidoglycan [1]. Two tandem repeats fold into a pseudo-2-fold symmetric single-domain structure containing numerous contacts between the repeats [1]. FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats lay at the periplasmic C-terminus. FtsN localises to the septum ring complex.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.47	0.72	-3.82	136	7624	2009-01-15 18:05:59	2003-04-07 12:59:11	8	118	2474	2	1762	5585	1681	74.80	19	23.88	CHANGED	ssssahlQlu.uhs...spssAcphhscLptp.sht...........sthpssssha+Vhl.GsasspppA..pphtp.pLp.......tthsshlhp	.........................................t..ttahlQlu.uhp..........stspA....pp....h.tt..p....Lptp..uhs..................sphtsss..shaRlhl.G.....sass+ppA....pphhp.pLp......tthpshh..h..................................	0	527	1100	1450
+4487	PF03845	Spore_permease		Spore germination protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.94	0.70	-5.78	17	1773	2012-10-03 01:44:59	2003-04-07 12:59:11	8	5	343	0	394	2732	134	306.50	19	86.06	CHANGED	plostQhhhlIhsh.lGsGlLshstshAcps.t..uWIullluullshlhhhlhhhlhpp..asppslhphhpchhG.KhLGtllshlahhYFlhhush.lRshuEllthahh.csPhahlshhhhhlslYhlhpGlcsluR....hhhhhhhhhhhhhhlhlhshphhchcNLhPlhspGlhslL+u..stsshhsasshElhlhlhsahpspKpst+hshhuhhlsslhYhloshlsIsshus-hsppthaPtlshhcslcls..hl-Rh-hhhlhlahlhhFhshslhhausshuhsplF+hpppp......hlhhlhslhhlhs.lhpsts.h	..............................................................................................................................ls.hphhhhlh...h....lG..s..u.....l.L...sh...sph...hs..pts...t..D....u.....W.l..u...l...l.l.u......sl.hs....h.l..h.h..h...h..h....h.h....l.h.pp............h.s..s..t......s......h....h...p..h.h.........p.p.h..h......G....+........h......l.G.......p......l......l.s.....h....l.......a.......h....h.......a....h...h....h....h.s...s.......h..h...........l.......p....s....h....s.....p.......l...l.p...h...a......l...........h.............s............p.................T...P..h..h..............h..............l..............h............h..............h..............h.h...l.........l.........s.h.........Y....h....s........t.t..G.......hc.........s...ls+............hhthh....h...s...h.h....h.l...h...h....h.h.....l.........h....h..........h............s...........h..........p.................h..........c............h.........p....p........l........h......P...............l............h.......p............p.........u.......h...h........s........l.....lpu........sth.s..h...h....s....a....h..uh.t....l.h.h.....h.l.h.P.a.l....p......p....p.....p....p..h..h.+.....s.h.h...h.u..h....h......h.s.s.l..h.h......hh.h.sl.hsl.s.hh.......u..p.th..tp..h..haP.s...l.ph.h..+h.l.p.ls.......a..l-.R.h.-h....lhl.....h...h....Wh....h....s..lhss..h.....s.hhh.a.sssh..s..hp....p.........l.........h.p.h...pppp........hl.h.h.h.h.s.l..l..hh.h.s.hh........h..............................................................................................................................	0	202	327	345
+4488	PF00588	SpoU_methylase		SpoU rRNA Methylase family	Bateman A	anon	MRC-LMB Genome group	Family	This family of proteins probably use S-AdoMet. 	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.89	0.71	-4.31	139	17854	2012-10-01 22:53:19	2003-04-07 12:59:11	14	38	4871	41	4348	12081	7850	141.80	26	56.74	CHANGED	shhllLsplpcPtNlGulhRostshGs.pslhl..hp.psh...hssp....sh+s.uhGu.h.hls.hhhh...sshpc.hlpp..lcpt.s.hhl..hus....sh....pup......shh...........ph....sht.......pthsllhGsEspGlspphhctsc.t..hlpIPh.tsph.pSLNlusAsul.hla	...........................................................................................s.hhllLppspcPtNlGslhRossshGs....p...s...lhl.............s.....p........t....sh...................s..tp.................s.h+s.....uhG....u......hp.h..l....s...l.hhh.................s..s............l..s..p.....h............l.p..p............hptt....t.....h...h.l..............hus....st........sup............shh...............ch.............shs......................................................tshsllh......GsE......sp.G..l...s...p..p....h........h....p..t.....s....-....t...............hl.p.I.........P........h......t............s............p.............s.....p...............S.LNlus.AsullhY...............................................	0	1420	2797	3687
+4489	PF03862	SpoVA	spoVA;	SpoVA protein	Finn RD	anon	DOMO:DM07026;	Family	Members of this family are all transcribed from the spoVA operon. These proteins are poorly characterised, but are thought to be involved in dipicolinic acid transport into the developing forespore during sporulation [1].	25.00	25.00	27.40	26.90	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.38	0.71	-4.00	73	1094	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	417	0	209	677	19	114.50	41	85.14	CHANGED	hs.hlpAFlVGGlICsIGQllhshh.....h..chssshshlshlhlGulLTGlGlY-clucaAGAGusVPlTGFuNulsuuAlEappEGhlhGlusshFplAGslIsaGlhsualhuLIa	.....shlhAFlVGGlICslGQllhchh...........+hssshshsohVhlGAlLsGh.....GlYDclspFAGAGusVPlTGFGNSlspuAhEttpc..shllGlus...shFcluuusIshullhualhuLI............................................	0	103	167	179
+4490	PF04026	SpoVG		SpoVG	Kerrison ND, Finn RD	anon	COG2088	Family	Stage V sporulation protein G. Essential for sporulation and specific to stage V sporulation in Bacillus megaterium and subtilis [2]. In B. subtilis, expression decreases after 30-60 minutes of cold shock [1].	22.00	22.00	22.50	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.89	0.72	-3.95	34	963	2009-09-11 01:05:24	2003-04-07 12:59:11	7	3	793	10	180	528	40	83.90	54	80.87	CHANGED	MplTDVRl+plssc...u+lKAhsSlThDssFVV+DlKVI-G.ppG.LFlAMPSRKst-....................................Gpa+DIAHPIssEhRpplpcuVlctYccth	.............................................MplTDVRlR...+.lps-......G+MKAlsSITl..Dc....p.FVlHDl+V.I-G.psG.....LFVAMP...S+..+.Ts.D....................................GEFRDIAHPINS-hRpcIQcAVlptYcc..h.......................	0	100	147	165
+4491	PF04293	SpoVR		SpoVR like protein	Kerrison ND, Finn RD	anon	COG2719	Family	Family member Swiss:P37875 is Bacillus subtilis stage V sporulation protein R, which is involved in spore cortex formation [1].  Little is known about cortex biosynthesis, except that it depends on several sigma E  controlled genes, including spoVR [2].	18.50	18.50	19.80	19.00	18.30	16.30	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.78	0.70	-6.11	62	1383	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1289	0	332	906	166	407.70	54	84.95	CHANGED	us-WsFchLpphpccIpclA.ccaGLDsYPsQlElIouEQMhDAYASsGMPltYpHWSFGKpFhpscptY++GhhGLAYEIVINSsPCIAYLMEENohsMQsLVlAHAsYGHNsFFKsNaLF+pWTDApuIlDYLsFA+sYIscCE-+..aGh-tVEplLDusHALhsaGVDRYtRstplShpcEctRp.....p-Rctahp.pphN-LW..RTlP..........pcppttpp..............ppt.+aPtcPpENlLYFlEKpAPhLEsWQREllRIVRcluQYFYPQ+QTpVMNEGWAoFWHYsIhNcLacpGtlsDuhhlEFLpSHosVlhQP.hssPtaoGINPYsLGFshhpDIcRICppPT-ED+cWFP...-l.......AGs.shhcsLc.Ahcsa+DESFIpQaLSPclhR-h+LFsltD-sccs..hpVsuIHsEcGY+plRcpLuppYslush-PsIQVhclDhpGDR	............................................GsDWTF-LLchYhsEIc+lA.chYtLDsYPpQIE.lITuEQMMDAYuSlGMPlsYsHWSFGK+FlcTEphY++GQpGLAYEIV.......INSNPCIAYLMEENTlsMQAL.VhAHAsYGHNSFFKNNYLF.................+sWT......D...................A..s........u....I..lD..............YLlFA+pYIscCEER..YGl-EVEclLDSCHALMNaGVDRY........K....RP.p.K.l.S...h.pE.E.csRp..........................cpREcY..LQ....SQVN....LW....RTlP+.......................cc.ccp..ps.................t...ct+RaPs..E.PQENlLYFh..........E..........Kp..........AP..........L..........L..........E....s....WQREILRIVRKluQYFYPQ+QTQV..MNEGWATFWHYTILNcLY-.......cGclT-.cFMlEFL+SHTsVVhQPsasuPaaSGINPYALGFAMFpDI+RICpsP.........T-.......E.D+.hWFP...........-l............AGu..cWL-sL+aAMcsFKDESFIsQaLSP+lhR-h+hFslhDD-+csh.lcluAIHs-cGY+pIRppLusQYsLushEPNIQVasVDh+GDR..................................................	0	93	198	268
+4492	PF04232	SpoVS		Stage V sporulation protein S (SpoVS)	Kerrison ND, Finn RD	anon	COG2359	Family	In Bacillus subtilis this protein interferes with sporulation at an early stage and this inhibitory effect is overcome by SpoIIB and SpoVG.  SpoVS seems to play a positive role in allowing progression beyond stage V of sporulation.  Null mutations in the spoVS gene block sporulation at stage V, impairing the development of heat resistance and coat assembly [1].	20.60	20.60	21.50	21.00	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.72	0.72	-4.41	26	629	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	425	4	199	331	10	85.30	63	87.47	CHANGED	ME.lLKVSu+SsPsuVAGAlAullRcpupsElQAIGAGAlNQAVKAlAIARGalAPsGlDLlslPAFs-lpI-GE-RTAIKhlVpsR	.........MElLKVSu+.SsPNSVAGALAGVlR.E+..G.sA..EIQAI...GA.......GAlNQAVKAlAIAR.G.FV...AP..oGl..DL.lClPAFs-IpI.DG...E....ERTAIKLIVpP........................	1	106	166	186
+4493	PF03539	Spuma_A9PTase		Spumavirus aspartic protease (A9)	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.90	20.90	21.00	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.03	0.71	-4.32	4	22	2012-10-02 15:32:34	2003-04-07 12:59:11	9	6	15	1	2	24	0	147.80	49	14.35	CHANGED	IKGs+LKGaWDSGA-ITCVPthaL.-EcPltpphIpTIHGppcpDVYYlshKIpGRKlpsEVIuTsLDYlllsPuDlPWhhKtPLELTIKlDlccQQcpLLpposLSpcGKchLKcLF.KYsALWQpWENQVGHRRIcPHKIATGTLpP+PQKQY+INPKAKs	.........................hKGsKLpuaWDSGApITClPpsaLppEpPltpp.lpTIHGppppsVYYlphKlpGRKlpsEVIuosh-YhllsPsDlPWhhppPLpLTlhlslp-.pcplLpposLscctKppLppLhpKYssLWQpWENQVGHR+IpPHpIATGThtP+PQKQY.INPKAKs....	1	2	2	2
+4494	PF03779	SPW		SPW repeat	Yeats C	anon	Yeats C	Repeat	A short repeat found in a small family  of membrane-bound proteins. This repeat contains a conserved SPW motif in the first of two transmembrane helices.	20.80	20.80	20.90	21.00	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.78	0.72	-4.59	16	414	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	200	0	160	360	9	51.30	29	53.28	CHANGED	hpWshsllGlWhllSPWIl.Ga.ossuuhhhsslIsGllVslLu...lhhutsspc	.............hhshllGl...alhhSPWll..Ga...uss.s.u..hhhss.llsGlllslLu.....hhhh.....t.............	0	38	108	138
+4495	PF00494	SQS_PSY		Squalene/phytoene synthase	Finn RD	anon	Prosite	Domain	\N	26.00	26.00	26.00	26.10	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.85	0.70	-5.10	152	3383	2009-01-15 18:05:59	2003-04-07 12:59:11	14	23	1893	58	1260	3142	2434	253.00	23	78.59	CHANGED	hcptucoFhhushhLs.tphRpslhslYuasRhsD-lsDpss...............s.stttph..................Lptacptlpthh................................................t......ps....lh.......................psltpshpphp.........lshp..hhtpllcuh....thDlp....................................pp........hh.ohs-.........LppYshtsAus..VGhhhhplh...sh..............ssp.......t..hphA............................p.....p...........lGhAhQlsNllRDlscD................htp...GR.hYLPt-..hh.tp..........sls.p.....plht........................stt.hpthhp.........................phhstAcphhpputshltt.............................l.sttsphshhhshslh.ttlLc...p.lcpssht.h.....hp..tRsplsthc	...............................................................................................................................................h..phucoFhhuh.hhLs..tph.Rpslhs.lYshsRthD..-..lsDsss...............sst.tth..................h.Lptacppl.pp.hh............................................................................................ht.stcs..lh..........................................tsL.t.p.sh...p.pat....................lshp...htshl....suh.....thD..lpt........................sp.........ht.shs-L.tt..YChtsAus..VGhhhstlh.uh..t..............................................pst...............ts..hphA............................pp........lGhAhQl.sNllR.DlsED.....................................hpp......GR..lY...lPt-....h..tp.......h..sl...s....p.....clhttt............................stt..ht..phhp.........................thhppAc.phhppu.ht.hlst.........................................l...s..t..p..s..t..h..sh..h...hshhhh.hthLpt.lptssh..t.h........p...t+h.l....t............................................................................................................	0	384	788	1058
+4496	PF00299	Squash	squash; 	Squash family serine protease inhibitor	Finn RD	anon	Prosite	Domain	\N	22.00	22.00	23.20	26.10	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.73	0.72	-4.13	12	37	2012-10-01 19:46:11	2003-04-07 12:59:11	13	1	17	32	0	60	0	28.70	64	90.24	CHANGED	RhCPRILMcCK+DSDCLucClClcph.aCG	..RhCPRILMcCKpDSDCLupClChcp.G.aCG...	0	0	0	0
+4497	PF02117	7TM_GPCR_Sra	Sra; 7TM_GCPR_Sra; 	Serpentine type 7TM GPCR chemoreceptor Sra	Mian N, Bateman A	anon	IPR000344	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	18.90	18.90	19.40	19.10	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.96	0.70	-5.82	10	141	2012-10-03 04:04:29	2003-04-07 12:59:11	11	3	7	0	141	262	0	276.40	20	94.23	CHANGED	MSs.sCAScsclpRhsSLNF+IuQalsLlsIllTFIhTYaAlKllhp+SIFplSTKILLhpNLFaANLHQlhYuIpslphLY+uFFhls-PCshLpoEt-CthYhcVLlsGsSGMlYuQTGLLIERsCATFl+sYcpKpShhsGlsISIlVLhsShuTu+IIIWDDPL-salLuCahaPpcSssRushFhsIsTlLolFNLllSllIh+YNK+LEY..STRFpVusRFpKRElI-STpTICFLshoQFlhhFlYShGlhlL+pI+..phIshcpaahhVVWsYTlPFIAlhFPlLLIYRIRpo+ssRsphIpplTspKQTQ-EHI+QhKshW	.........................................................................................................................................s....h.h.h.pS..hhhs.h...h...hhh...h.h.o...h...h.hshh...u...l.....p.hl....hp...p...s...l....a..........p.....u....T+....hLLh..slh.ss...hHp.h..h...............h.....h.......................t......hh...................l....h..........+s.....h..h..h.....sc.sCp.lh..h.pp.....-Ch.........h.h.h.hh.h...s....h...h...h.h....h..ph......u....Lh.l-R..............hhup.h.h...p.h......t.ph.phh..u..h.h...............l......h....hhlh....h.oh.................h........s.h....hh.....h....h.h....s...s...sh...ss.h.h...s.C.hh.....st......s.h..t..p.........h....p....h..hhh..h..hh..h.l...s...lh..s.h.l..h..s.h..h....lh.hh....s.....p.+.h.ch...............p.pp.apl...t........tRapp..hEsl.oopsl...s..hlsh....hQhlhh...hla.shs.h....hhhh...h..p..p...h...s.......h....a....h......h..h.....a.h..a...............s...h..s.ahs...h...hhPhllh.h.p....h..p.http.R...t.......t....I....t.t.h.pt..t........ts....pp.a.h.tp.hpt.W................................................................	0	43	57	141
+4498	PF02175	7TM_GPCR_Srb	Srb; 	Serpentine type 7TM GPCR chemoreceptor Srb	Mian N, Bateman A	anon	IPR002184	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srb is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	21.70	21.70	21.90	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.64	0.70	-4.81	3	69	2012-10-03 04:04:29	2003-04-07 12:59:11	11	4	5	0	68	166	0	199.20	35	65.84	CHANGED	FHPVYRlAQFYoFhVSsFAhPuLIYFMFcKLFKLsFHGNLKsLLIuYFIolLLFAlhlCFsFGYQFFVPFFl+SNCDLIINuTLFKYGHsoulFlMTlPMlLPluFTIERFsAMKMAcoYE+lRTLLGPVLVllLIIIDshhlYhIappEsFDcsFISFlllPuToA.LsFNoFLWalLYLNIsNFlhNllLLhlH+KLKpRhhh+NoSLSTKYplEEISQSS+FTLIVTFTHLLFF	...........................................................apslaRhu.haphhluhhuh..sLh...a...F...lhh...+l.h...................F..HsNL.K.......h..............l....h..hsYFhshhl...auh...........hhh.h...s.h............h...hphh....h....P.F...........h....s..p...s.p.CsL....l...I.s.......h...h....aKh..hphhhh.hhhTh...s..hhh..P.huhoIERalAhth.AcpYEps..s.hLGPl.L..s...h..h..h...............h.hh.shhl.....hhhlac.s.....E.pFs.ss.l.S.F....hh..h..P.ss......s..........A.........p..h......a...h.h..h..L...l..hl.p.hhNhl.h..N.hhL.lhh......p....p..+h.Kp...................................pps.o..Los+Yph.EE....lhpS.oK.Fs.l..h..lhF.hHllFF.........................................................................................	0	13	20	68
+4499	PF00530	SRCR		Scavenger receptor cysteine-rich domain	Bateman A	anon	Reference [1]	Domain	These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.	26.10	26.10	26.10	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-11.18	0.72	-3.66	136	8985	2012-10-03 20:35:02	2003-04-07 12:59:11	13	369	133	13	6194	7713	21	96.30	35	47.20	CHANGED	ssGss...spGRVEl.h.........s.G.........pWGsVCss.s.......Wshp..sApVlCRp..LG........h.ssshps.tsssh...........ts.ts.....lh..hss.....lp......CpG.sEssLtpC...........pshst..ps...C.sp.t..ps....suVhCp	..............................................................................sGsst...s..pG.RVEV.h.............s..G............pW.GT............V.CDc..s...........Ws....hp....-........Ap...VVCRQ....LG.................................h..usu.h..ps...tssta............................GtG..sGs.........lh....lcs..................lp........................C.......p.......G.....s.......E.........s..s....L...h.pC..........................t......ps.h.st......ps............C...sH...p......cD......Au.VhC...................................................................	0	3267	3815	4627
+4500	PF00319	SRF-TF	transcript_fact; 	SRF-type transcription factor (DNA-binding and dimerisation domain)	Finn RD	anon	Prosite & Pfam-B_6396 (Release 8.0)	Domain	\N	20.40	20.40	20.40	20.60	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.43	0.72	-4.73	10	5768	2009-01-15 18:05:59	2003-04-07 12:59:11	13	20	1081	36	1424	5480	5	47.50	55	19.44	CHANGED	KpIENpoNRpVTFSKR+sGlhKKAaELSVLCDs-VulIlaSssG+LaEauo	.................................+I-NptsRQVTFoK...R.R.sGLhKKAh.EL.S.VL..C.D.A-Vu.L.I..l.F....S..s.s....G..KL..a-aso................	0	300	819	1128
+4501	PF02118	Srg		Srg family chemoreceptor	Mian N, Bateman A	anon	IPR000609	Family	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.76	0.70	-4.96	49	400	2012-10-03 04:04:29	2003-04-07 12:59:11	16	10	7	0	395	556	0	228.30	17	81.72	CHANGED	hhlQhsYhlPuhhLhlhhlhhlhhs++...ahpsSFatLaphDhlsslhhhl.shhhsRlhhah..lC.hhs.h.hhssshhhshhhhhhhahhthphloplhlolsRho.sVhaPhpapphWp+hh..lllhlhllPahhlWshll...u.ps.lthh...tGshhhsahctl....assho...hapllahlhslhlslhoshlshh+lpths.p+hcplE+pLshhshhhohsahhhshhphh.....hshhhshhs..hhphhhhhhhhs.Dhhslut.............PhlLllhssplRppl	........................................................h.h.Yh..h.sh..h..lh....h.h...h....h...h....h....l...h...h...t...p..t......................pp..sF.....ah..l........h...hsh..........h.....h...............shhhhh...........shhh.Rh..h............s...h...h....h.....................t........s.......h........h....hp.h.h.h...hhh...a.hhh.....h....p.h.t...hhhshsRho.slh..h........h......p...............h...............p...............p..............h...W..p..............p........h......h.....h......h..h....h..hl..h..hh....s.h.h...h..h.h.phhh.............t.thh.h.......h.......s....s...h.h..h.......h....p.h..........................h..sth..............hh...h...h...h.....h..h.h.h..h.h..h...s...l..h...s...sh..h.......s..h....h............p.......h.........t..........t...............h..............t.......t............p..........h.............p............p..............h.............p........p..p....l...h.......h........h..s.h..h...h.sh....hhh....hhhhhphh................h...hh.t...........thhh.......h..hs...Dh...h....sls..............................................shhh.lhhstpl+t..............................................................................................	0	119	168	395
+4502	PF02290	SRP14		Signal recognition particle 14kD protein	Mian N, Bateman A	anon	Pfam-B_7955 (release 5.2)	Family	The signal recognition particle (SRP) is a multimeric protein  involved in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP14 and SRP9 form a complex essential for  SRP RNA binding.	21.20	21.20	21.90	21.90	20.70	18.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.37	0.72	-4.07	22	297	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	258	6	206	281	2	95.60	33	71.62	CHANGED	Lss-pFLocLocLapcsppcu..SValThK+h..........ssps.ps.spssp......shpp....ssp.tsLlRAosG....................pK.KlSTlVpsc-ltp..FhtsYuslh+upMsuL	.....................Lps-pFLscLscLap...pscppu..SValThK+h.......................................................shps..ps.spptp................spstp........ssp....sLlRA.o.sG.......................cK.KlST.............lV........psc-lsp..F.ttYuslhKusMsuL................	0	61	103	162
+4503	PF01922	SRP19		SRP19 protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein [1] (Sec65 in yeast [2,3]).	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.09	0.72	-3.41	77	498	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	439	21	335	512	73	93.80	33	54.93	CHANGED	hllYPsYlDsp+o+scGR+lspphAVcsPphpEItcAs.cpLslpsh.lE.cKtaP+c.....atppGR....VtVphcp.........................sKpplhptlAphlpph+	...................slYPsYlssp+ohuE.G.RRlspph.......AVc.sPpspEIt-ss..ptl.....G......lssh...lE...sKtaP+-...............a.tttGR....V+Vpl+p.................................t.h..th.sKcplhhhlAphl.ph........................................................	1	106	190	274
+4504	PF00660	SRP1_TIP1		Seripauperin and TIP1 family	Bateman A	anon	Prosite	Family	\N	25.00	25.00	27.00	26.30	22.40	21.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.48	0.72	-4.21	14	386	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	42	0	177	280	0	99.90	47	50.10	CHANGED	hsulusAssps........plsELssllsDl+upLs-Yhuhtts.sosh...shPssllslh.th.uohTDDSaTThhoplsFstlophlTtlPWYSoRLh.....PslsusLussususu	.......................hsoLAtuD-cl........sl..l.ELsVaVoDI+AHLupYh.Fpuspso-....ThPs-lA-........As..a..s..h..s.sa.TTh..L..T..u...I....s.s..-QVT+hITuVPWYSoRLc....PAIouALupsGIho...................................	0	34	66	111
+4505	PF05022	SRP40_C		SRP40, C-terminal domain	Wood V, Bateman A	anon	Pfam-B_9034 (release 7.6)	Domain	This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein Swiss:P32583 and its homologues. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.	20.90	20.90	21.40	24.30	18.90	20.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.69	0.72	-3.48	35	306	2009-09-11 14:16:26	2003-04-07 12:59:11	7	10	256	0	204	294	1	71.00	45	13.93	CHANGED	s.FpRlc....hpclph.cpcLtDNoYtuts......ssaGcKAsccLthsRGKsFTKEKNKKKRGSY+G.GpIs.hussShKF	.....................FpRlc.....pc.l..p.....hc.scltDNoapupt.......ssaGc.....+AsccLthT+GKuFp+EKsKKKRG.....SYRG..G...sIs..hpsp.ShKF.......	2	74	119	170
+4506	PF04888	SseC		Secretion system effector C (SseC) like family 	Finn RD	anon	Pfam-B_5525 (release 7.6)	Family	SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella.  All these proteins are secreted by the type III secretion system [1]. Many mucosal pathogens use type III secretion systems for the injection of effector proteins into target cells.  SecB, SseC and SecD are inserted into the target cell membrane.  where they form a small pore or translocon [1,2]. In addition to SseC, this family includes the bacterial secreted proteins PopB, PepB, YopB and EspD which are thought to be directly involved in pore formation, and type III secretion system translocon.	29.00	29.00	29.20	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.14	0.70	-5.09	35	864	2009-09-11 03:00:25	2003-04-07 12:59:11	7	2	470	0	55	430	6	247.80	21	61.88	CHANGED	lhhthsplhuchtppphpsphpphpphppppp....pchp-hpcplccttcpu...ccApKs.Gl...huKIhGWlusllollsuAh.......hhlsusulGs.....suAhhlusss..suhlutustp.u..............shsuhluptl.spsLsshsh..tth..hsttlstu..lssslsshu.....sssssssushsspsAuc.husthsttht..hht.hhtthhphhtp..tp.........................hhs..........................ptlphss.ssplssslsp.....................Gusphssushpppuspt.A-hthtpst..hptlpshhcphh-phsp..hhcshpphhpthhphls..spusstsplspps	.......................h.hhhhtlhhpsttpphps.ht.hpthpcspp....tphpchppphpct.ctt.....ccs..p+...sh.....hutlhshlhshhsslhush..................sh.hhhhGh............shhhusth......shstsuh.t.h..................................................ht.lthth.......stslt.hhsh..t.h...............hs.tt.lssu...hstslt.ht...................hh.sstt.hhtthAtt.hspt...hs.p.h.p...........................................................................................................................................................t....shphssthtp......................................................uhsthtts.hptph.phhAp.th.phh...p.hpphhc..hcthtp.........p..tphhpth.p.hp....ut.thhhht..t..................................................	0	17	23	39
+4507	PF00474	SSF		Sodium:solute symporter family	Finn RD	anon	Prosite	Family	This family includes Swiss:P33413 which is not in the Prosite entry.  Membership of this family is supported by a significant blast score.	19.80	19.80	19.80	19.80	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.29	0.70	-5.83	10	13052	2012-10-03 01:44:59	2003-04-07 12:59:11	12	51	3717	6	4094	10595	8262	353.80	21	74.16	CHANGED	YaLAGRShssashGhSlsASshSuupFlGLuGsuhtSGluhuhauhstLlslhllhallushat.....psGslThP-YlptRFtu++.lllaLSuLuLLlhlshthouslluGAtLIcpslGlsYpsAlllluuhTslYTlhGGhhAVsaTDTlQullMlhGsllLhlhshhclG..Ghsshhp+hhsAsPph..sDh..........hs...ssuhp.h+sPlstsShWsuhshGhsGl........PHIltRshuuK.....cu+slhpGhlhuhshhlllhsGhluhhhashclAsssP....cssGsplssuNhAaPpLshcLhPshltGlhLAlhlAAlMSoLsulhluuSohFTcDlYppl++cutssEpclsthutlhsLllsulAllsulpsspts.lhhhlphAauhLuushusVlLLulFWcRsNppGAhhGhIlG	............................................................................................ahhuG+.sh.s..s.h.h...h..uhuhh.us....h...S.uhp.h.....l.G..h.s.u....h.s.......a..h...............G....h..s...h.......h.......h..h....s.....h..s............h....h..h..u.....h.h...l..h...h..h...l...h.s....h.ht.......................p.h..s...h...h....T.h..s.....-....hhp..t...R....a....t........s......p........h..............h.......p..h.............l.......u.....u.l......h.........h....l.........l...........h......h....h........h...h.....h.....s...............s.........t.....h.............h.....u.......s....u..........h..........h......h........p.....................h........h..........G..........l.............s...................h..............................h.......u..............l...............h.............l....h....s....h....l...h............h.....h............Y.s...h..h.....G...........G...hhu...s.........s...hs..D.hl...Q.....s.................h.....l....h...l..h..u........h..h....h........h...h..h....h........s........h.....h........t......h..G..............u...h....s....t....h.......h....p.....t...h..........t....h...t..s...........th..................................................................hp......s..s...........................................h............h......h....s...h.............h........s...h......h....h....G...h.h.s......................p.h.l...Rh.hssc..............sh.p.t.h..h.....p.....u.....h.....h.......h......s.....h.......h.......h.....h.....h.....h......h......h.....h....h............h.....h.....h.....s.....h.....h........s.......h....h.....h.....h.....................................................h..........................t...s....s.....p........h......h...h.........h.h.......h.............t........h........h.........s...............s.......h.........h.....h...G.........l....h...h..u....s.....h....h.....A...A.........h.....h.S..o..hs....u...l...s.s..u..osh...s....pD.......l......a.................t...t.......h.....h...........p...............p.....t...............................t.........s..............p..............p............p......h....h......h........h....u....+....h.......h....s.....l......h..........h....u....h....l....s........h....h....h...u.....h...................t....s.....................l...h.......h...h.............h...h...h.u........h.h.s.........us..h...hsh...h.l.h.u.l..a...a.p....+....h..s...t........GA.hhuhhhG................................................................................................................................................................................................................	1	1309	2409	3400
+4508	PF04686	SsgA		Streptomyces sporulation and cell division protein, SsgA	Mifsud W	anon	Pfam-B_5645 (release 7.5)	Family	The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division [1].	25.00	25.00	26.10	25.70	20.70	19.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.20	0.72	-4.33	27	307	2009-09-11 07:36:54	2003-04-07 12:59:11	7	1	100	3	119	297	0	99.20	41	68.34	CHANGED	sls..spLRY-ss.DPaAVplsF.psss..stsV.pWsFuR-LLt-Glp..pPsGpGDVRlhPs.tt..spshlhlpL...suPsG...pAllchssstltsFLcRT.thVPsGpEp	.....................lPspL+Y-ss....DP.aAV+hsF..+sss......stsV.pWsFuR-LLscGLp....pPsGpGDVRlhPs..t.......uts.tl.hl.pL......puPsG...pAllcsssssLtsFLcRT.plVP.GpE........	0	30	93	118
+4509	PF00720	SSI		Subtilisin inhibitor-like	Bateman A	anon	Pfam-B_679 (release 2.1)	Domain	\N	21.80	21.80	22.10	23.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.25	0.72	-4.06	22	154	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	96	4	53	172	1	89.80	34	64.64	CHANGED	YAPSALVLTlGpGpuAAoAsspRAVTLoCsPssuGTHPustuACApL+u..ssGDhstL...sspssthCT+pacPVsVTs-GVWpG+RVuaE+TFuNp	.................................hsh..s..s..sss..+uss....LsC...s...Ps...uGo.HPsstuACApLcs..s..s....G.c.h.ssl.....ssssthCThp.Y.s.P.Vss.sssGsWpG+tVsappsasN.........	0	20	44	53
+4510	PF04056	Ssl1		Ssl1-like	Wood V, Finn RD	anon	Pfam-B_13499 (release 7.3);	Family	Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.20	0.71	-4.71	6	389	2012-10-10 16:07:06	2003-04-07 12:59:11	9	14	298	0	266	650	20	173.80	38	45.11	CHANGED	VlDsScuMp-pDh+PsRhshhlKhlptFlcEFFDQNPISQlGlIshKsthAc+lT-LoGNPcsHIcuLcoltp.pspG-sSLQNAL-hAptsLptlPuHsoREVLIlauSLoTsDPGDIapTI-sLK+ppIRsSVIGLSAEltlCKcLsppTs.G...tYuVlLDEsHh+-LLhcpssPPPuspsp..csoLI+MGFP	...........................llDhSpu.M...t.-.pD..h+....P.sRh.th..s.lph..h..........ptFlcEaF.-QNPISQlGlls..h+s..thApp.l.o..........-.............lo.....G......NPp....cHlpuL...........pph.......h.....p...........p..s...p......G....pPS..LQNuLchAh.........t.tL.....h.........p......h......P..u....+..s..o..R.E.............l..Ll.lh..u.u....L..s..osD.P.u...s........I.a..psI.ps..L.hp.ppIRlu..ll....GL...uA...plt...lCpplsppTs...G................pYtVhls-..pH..h+-.L.lhph.ssPP....ss..........t..........t.......tt.................tss........L...lh..M.GFP.......................................................................	1	99	149	221
+4511	PF04386	SspB		Stringent starvation protein B	Kerrison ND	anon	COG2969	Family	Escherichia coli stringent starvation protein B (SspB), is thought to enhance the specificity of degradation of tmRNA-tagged proteins by the ClpXP protease.  The tmRNA tag, also known as ssrA, is an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP.  SspB a cytoplasmic protein that specifically binds to residues 1-4 and 7 of the tag. Binding of SspB enhances degradation of tagged proteins by ClpX, and masks sequence elements important for ClpA interactions, inhibiting degradation by ClpA [1]. However, more recent work has cast doubt on the importance of SspB in wild-type cells [2]. SspB is encoded in an operon whose synthesis is stimulated by carbon, amino acid, and phosphate starvation.  SspB may play a special role during nutrient stress, for example by ensuring rapid degradation of the products of stalled translation, without causing a global increase in degradation of all ClpXP substrates [3].	20.00	20.00	20.00	20.20	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.74	0.71	-4.61	137	1666	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1653	33	367	1037	412	152.90	35	95.39	CHANGED	hs..sht.hhlRulhchl...........lssshp.aIshcsptsG..VplPpphh.c.sp.hhslhtcthtsLplss-t..hphshpFuGhPcplhlPhsAlhuhas.pssh.GhhF-spss.tt..............................................................ststtspsp...ttts.csshcVVp	...........................................h....spRPYLLRAhY-Wl..............lDNphTPa..llVcssh..PG..VpVPhcas.+DGpI..VLN.l...us+...As.s.sL..clsN-t....lpFsARFGG..lP+plhVPluAVlAIY.ARE..N..Gt.GhhF-....sEsshscsss......................................................t.tt.spp.........ssspsspt...s.tts+PsL+VVp....................................................................................................................................................................................................................................	2	87	197	277
+4512	PF03531	SSrecog		Structure-specific recognition protein (SSRP1)	Griffiths-Jones SR, Mistry J	anon	PRINTS	Domain	SSRP1 has been implicated in transcriptional initiation and elongation and in DNA replication and repair [1]. This domain belongs to the Pleckstrin homology fold superfamily.	25.00	25.00	25.30	26.10	24.80	21.10	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.46	0.70	-5.02	6	417	2012-10-04 00:02:25	2003-04-07 12:59:11	9	9	289	7	279	395	7	199.50	39	38.01	CHANGED	FsGFR-pDlscLtsFhpusauhshsEKpLsVpGWNWGpschtGshLoFslsS+sAFElPLosVSQs.lsGKNEVsLEFHpsDsutl......uLMEhRFHlPso.tpptsuD.......ssphFtcslhuhADV.suot-AlshFc-ItlLTPRGRYDIcla.TFl+L+GKTaDYKI.YoSllRLFLLP+pDpppsFFVlSLDPPIRQGQT+YsaLVhpFspDE-h-l	.................................sGFppp-hpplpphh.cp..tap..hpltp.+-hsl+GWNWGpschs............t.....s.......L.....sF.s.......lts.+.ss.FElPhu.plSp..s...h...sG...K.....N.EVslEF....p..............s-s...sts......................................pLhE.hRFalPss.........p.......p...t...ttD...............................s...sp...hFhpplhpKAc.lhp.s.sG-slshF..p-.l...hL..TPRGRYDIcha.s.h+L+GKTaDYKI.apslhRlFlLP+t..Dph..ph....hhVluLDPPl+QGQTRY.aLVh.Fpp-E-h..h.......................	0	104	161	234
+4513	PF04722	Ssu72		Ssu72-like protein	Waterfield DI, Finn RD, Mistry J, Wood V	anon	Pfam-B_5993 (release 7.5)	Family	The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB [1].  It binds to TFIIB and is also involved in mRNA elongation.  Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation.  Ssu72 is also essential for transcription termination of snRNAs [4][5].	25.00	25.00	27.00	37.90	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.33	0.71	-5.00	27	359	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	268	27	254	362	2	191.20	49	89.59	CHANGED	spL.+hssVCASNpNRSMEuHphLtc..uGa.sVpSaGTGStV+LPGsShD+PNVYpFG.TsYc-IYsDLhupcp.ch...YcpNGLLpMLcRN+clKtuPE+Wpc...................ssct...FDlllTCEERsaDsVl-DLhsRt........sphpcsVHVlNlDI+DspEpAhlGuptIL-Lsphlp....................tsspshE-pl.cllscapcca.phshLaslsaY	...................L+hssVCuSNpNRSMEAHphLpc...........p.Ga.sVpSFGTGotV+LPGPuhccPNVYsFs.ToYcphYsDLhp..KDt..cL....YppNGlLpML-RN++lK.sPERaQc.........................sp-h.....FDlllTCEERsaDtVl-DL.sRt...............pphspPVHVINlDIpDNcE.EAtlGuhhIh-Lsptlp.......................tspsh-scls-lLtcapc+p.phshLaolsaY....................	0	79	124	185
+4514	PF04184	ST7		ST7 protein	Bateman A	anon	Pfam-B_2088 (release 7.3)	Family	The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.	19.10	19.10	21.70	19.50	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	540	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.86	0.70	-6.27	5	405	2012-10-11 20:00:59	2003-04-07 12:59:11	7	7	139	0	132	319	4	378.60	62	93.97	CHANGED	luWSWTYLWslWFAlVlhLlYlLRuPLKLpEsLsuVol..FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLlGGVDNoussuS..Sss-stpNRQNVuECKVWRNPLNLFRGAEYSRYpWVTG+EPLTYYDMNLSAQDHQTFFTCDoDpL..RPuDoIMQKAWRERNPQARIpAAapALElN......................P-CATAYVLLAEEEATTIoEAE+LFKQALKAu-shhR..pupphpupupph-A.+RRDTNVlVYIKRRLAMCARKLGRlREAVKMMRDLMKEFPLLSMLNIHENLLEALLELQAYADVQAVLAKYD........DISLPKSATICYTAALLKARAVSDKF..SPEuAuRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYAFFHLQHWKRlEGALNLLHCTWEGTFRhIPYPLEKGHLFYPYPuCTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFoAMLALLTHQFPELMGVFAKAslsllhusht..h.chcsahPusIhppLsst	...........................................................................................oh................FLsoLTPKFYVALT.GTSSLISGLIh.I.FEWWYF+KaGTSFIEQVSl.....s.......Hlp...P.hhGG........s-.ss.s..p.s.........s...sp..s.......................t.....................t..s............ps.s.ppsls...ECKVWRNPLNLFRGAEYp..RapWsTG.+.EPLTYYDMNLSAQDHQT.FF.TC-oDth.....R.PuD.slMQ+AWRERNP.ARIpAAapALElN...........................cCAsAYlLLAEEEATTIs-AE+LFKQ..ALKAG-shYR..pSQph..Q...Hpu.staEu...hRRD.TNVLlYIK..R..R..LAMCAR..+LGRh+EAVKhMRDLhKEa.P...hshhN..IHENLlEuLLElQAYADVQAVLAK.Y.D....................................D..ISLPKSAsICYTA.ALL.KsRsV.uDKF..SPEsAS+RGLSoAEhs..AVEAIHRAVEFNPHVP.KYLLEMKuL..I.LP.PEHILKRG.D.SEAlAYAFFHLtHWKRlEGALNLLpCTWEG.T.....FRhlPaPLE+GHLFYPYP.CTEsADRELLPs.FHcVSVYPKKELPhFIhFTAGlCS.TAhlAlL..THQaPE.MGlhA+s...h..h..........................h..............................................................................................................................................	0	33	46	86
+4515	PF03298	Stanniocalcin		Stanniocalcin family	Mifsud W	anon	Pfam-B_4401 (release 6.5)	Family	\N	20.70	20.70	20.90	20.90	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.69	0.70	-5.32	16	167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	69	0	77	133	0	193.90	45	78.10	CHANGED	Mlh+suL..LllhlLssuu.......aEss.--s..usR+uRhSsposu-VsRCLsuALpVGCGsFuCLENSTCDTDGMH-ICpoFLaoAAKFDTQGKoFVKESLKChAsGloSKhFhslRRCooFQcMluEVQcECYsKLDLCoVA+pNPpAIsEVlQlPspFPNRaYspLLpSLLsCDEETVssVRsSlhu+lGPshusLFplLQsssssssussu	.............................................................sh..llhhshs.st..........Es..pcu..u.p+u.RhuhpsoA-l.+CLssAhp..V.G..CGsF.tChE.N.s.o.C-hcG..h.....a.....-.....IChoFLasAuKFDsQGKuFlK-uL.KChA.p...ulp.pKhh.th..R+CsshpcMlhp...lQcECY.Kh..slCus...A+cNscsIsEhlph.shFs...p.c.YscLlp.LLpCsE-shpslpcSl.tpht.shuuLhplLphspss.tp..s.................................	0	17	25	43
+4516	PF02200	STE		STE like transcription factor	SMART	anon	Alignment kindly provided by SMART	Family	\N	25.00	25.00	47.60	47.60	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.51	0.72	-3.91	8	177	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	156	0	105	177	0	104.80	74	16.69	CHANGED	sQlIRRahLssG-.YlSCVhWNsLaaITGTDIVRsllaRFpsFGRslpspKKFEEGIFSDLRNLKsGsDAoLEpPKSPFL-FLY+NuCIRTQKKQKVFYWFSVPHD+LFsD	....................s.QhIRRFhLPoG-.aVSCVhWNNLaHIoGTDIVRCLsFRFQAFGRPV+NpKKFEEGIFSDLRNLKsGoDAoLEEPKSsFLDFLaKNsCIRTQKKQ...KVFYWaSVPHDRLFLD........	0	29	61	92
+4517	PF02876	Stap_Strp_tox_C		Staphylococcal/Streptococcal toxin, beta-grasp domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	\N	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.47	0.72	-3.88	41	3442	2012-10-01 21:38:54	2003-04-07 12:59:11	12	3	194	211	29	1049	1	99.20	31	42.23	CHANGED	+......pls.lslahcspppph....spplpssKcpVTlQELDhKlR+aLh..ccapLY.................sushppGhItaphss..sppasaDLa.h.s......pchLphYpDNKslcScpl.+I-VhLp	............................hh.sttp.t......tp.hphsKcploLKELDaKlRchLl..cpapLY.................pushppGpIplphcs..sspashDL...........sccLphpc.scslcuppltcI-V.l....................	1	16	24	28
+4518	PF01123	Stap_Strp_toxin		Staphylococcal/Streptococcal toxin, OB-fold domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	\N	20.70	20.70	20.80	20.90	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.10	0.72	-3.50	22	1277	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	190	179	10	523	0	85.50	32	37.19	CHANGED	NlpphYtshshsttp..thposcphlppsLlapsps.........pslpsEhsspphsppa.KsKpVDlaGl.YthpCht.t............hstshYGGVT.p	.........................NlpphYtp.phpphp..shpsscphLspsLlFps.t.........pslpsEFpspshusca.KsKpVDlaGlsYthpChh.t.............tspChYGGVTh................	3	1	8	9
+4519	PF04022	Staphylcoagulse		Staphylocoagulase repeat	Bateman A	anon	Prosite	Repeat	\N	19.70	19.70	20.20	26.20	18.90	16.60	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.17	0.72	-4.58	22	1401	2009-01-15 18:05:59	2003-04-07 12:59:11	7	18	155	0	5	881	0	26.90	84	26.32	CHANGED	RPTaNKPSETNAYNVTTHAsGpVSYGA	..RPT.NKPSETNAYNVTTHANGQVSYGA..	0	5	5	5
+4520	PF02821	Staphylokinase		Staphylokinase/Streptokinase family	Bateman A, Griffiths-Jones SR	anon	PDB	Domain	\N	21.70	21.70	21.90	31.20	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.29	0.71	-4.33	11	458	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	171	31	11	340	0	122.40	32	79.68	CHANGED	sstppsssshplphtspssDhchp.hlhs....hphtsschloppElttthpphlsp.sp.satlhppc.shhtcssshpt.p.hspcpphshhIss+ptthshsscsuhp.hhs...ptc.l.pchhlhcc	............................uph.sss.hl.hsspssDschs.lLpsphh.hsltsGsoLTppclthhspahLst.sa.-atlhEpDsShhhcssshh+.h.hsp-pphoahIp-+ttshstsscsshp.thN...pp..l.pKhhl.KK...................................	0	1	4	7
+4521	PF01017	STAT_alpha	STAT; 	STAT protein, all-alpha domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_856 (release 3.0)	Family	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.	27.50	27.50	27.70	27.70	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.10	0.71	-4.56	26	626	2009-01-15 18:05:59	2003-04-07 12:59:11	15	30	117	9	231	569	0	170.90	31	24.35	CHANGED	h-+Qppl-s+lppl+spsp.cs-psl+tLcchQ................-pasapap.......olpshtchp...hNs.t.ct.hppcphhlpphhp........pLphpRppllpchppllshlcplppslls-EL.-WK+RQQhACIGGP.s.pssLDQLQsWhTtlAEsLhQlRQQLK+lp-LppplsYssDPlspt+spLppplppLlpsLlpS	....................................................................................................pcp.plppplppl+thsp.ph-pch+tLp.....p..hQ...................-.aphpap..............plp....s......ht.php...............pt....s...p.........hpp.c....t....l.pphhp............tLp.phR...t..pllp.c....hp..p....hlshhcthQ....ptlls-ELhpWKRRQQlAs..GGP..s...ps...sLD..pLQsW...hptLAE.lhQhRQ....Ql++hcc.Lpp.p..h.shp.s.pP..ls.pths.L...ptplsplhpsLlpS............................................	0	34	51	117
+4522	PF02864	STAT_bind		STAT protein, DNA binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_856 (release 3.0)	Domain	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain Pfam:PF00017.	20.20	20.20	20.40	21.90	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.80	0.70	-4.78	9	708	2012-10-03 00:25:27	2003-04-07 12:59:11	10	35	125	9	273	620	4	217.30	41	33.61	CHANGED	FlVE+QPCMP.pPpRPLVLKTtspFTs+lRLLV+h.ELNhplKscslhD+pss-hts.ch.......R+FNlhGoso.KlhNhEco.ssSLus-FpaLph+E.+stsusRsNpcGshhVTEELHslsFEophshtG..LpIcLcThSLPVVVISNssQhPsAWASILWaNhhosps+N.sFFssPPtusWsQLuEsLSWQFSSpst..RGLs.-QLshLA-KLhspsus.....sstploWscFCKEphss+uFoFWhWl-uIlDLlK+	................................................................FllE+QP........P.Vl.KT.tspFss.pl..RL........LVth.cLNh..phps..s.h...s.....p..hs-.ts..th..................+p...s...h.h.......s......pso..cl....hN.pps...php....ssphhph...ph+..p...pht....t...htR.s...s....c...Gs........VT..EEhaslhF.pop.hshtu...........L....hhp......l......c......ThSLPV.VVIspss.Q.ssAhAolLW.Nhh.s.p.s..+.........s.FssPsts.WsQlsEsLs..hpFpu...st..........RGLs.-pLshLupKLh....s.ssst...........ssh.loWu.pF...sK..................E.s..........l.s.s..+......sF...oFW.Wh-ull-LlK+...............................	0	45	65	143
+4523	PF02865	STAT_int	STAT_prot; 	STAT protein, protein interaction domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_856 (release 3.0)	Domain	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.	26.00	26.00	29.50	26.40	25.30	25.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.69	0.71	-4.16	22	576	2009-01-15 18:05:59	2003-04-07 12:59:11	12	26	102	3	210	502	0	117.70	39	16.63	CHANGED	o.WtplQpLpschL-Q.lppLYsssF.PhElRpaLApWIEs..QsW-ths......s-shAshlhpsLlppLpcphpphspp.sshLhphplpcht.pplpsha.ppsPhplsthlpphLppEp+llppApps	...........utWhplQQ.LpschLcQ.lppLY.s.c.p.F.PhE...lRpaLApWIEs...Qs.W-ths.........cpshAohlhcsLl....ppLppphs+.......hs....tE.sshLlphplt+ht.ppL..Q..spa.pcsPhplsthIpphLhpEp+llppApps......................................	0	29	43	96
+4524	PF03875	Statherin		Statherin	Finn RD	anon	DOMO:DM07003;	Family	Statherin functions biologically to inhibit the  nucleation and growth of calcium phosphate minerals. The N-terminus of statherin is highly charge, the glutamic acids of which  have been shown to be  important in the recognition hydroxyapatite [1]. 	25.00	25.00	29.20	35.40	16.70	16.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.24	0.72	-4.08	2	11	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	8	0	1	8	0	39.40	74	68.08	CHANGED	DSSEEKFLRRltRFs.G.YGPYQPhs..PLYPQPYQP...QY	....DSSEE.KFLRRltRas.G.YGPYQPhPEQPLYPQPYQP.YQQY	0	1	1	1
+4525	PF00836	Stathmin		Stathmin family	Bateman A, Mistry J, Segerman B	anon	Pfam-B_1551 (release 2.1)	Family	The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton.  They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerisation of tubulin heterodimers [1].	20.40	20.40	20.40	20.60	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-11.03	0.71	-4.55	4	392	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	92	15	157	297	5	129.70	55	68.99	CHANGED	SDhcVKpLpKRASGQAFELILpPPSh-usP-hslosPKKKDhSLEEIQKKLEAAEERRK.pEAElLKQLAEKREHE+EVLQKAIEENNNFSKMAEEKLspKMEs.KENREAplAAhLERLpEKDKHsEEVRKNKEhK-.u	.......................................DhpVKplpKRASGQ.uFElILp.PPS...............u...s..........hsho.s.P....+.+.KD..hSL.E..EIQKKLEAAEERRK..op...EAplLKpLAE.KREHE+EV..lpK.A..lEE.NNNFsKhAcE...KLp.KM.......EtsKE.NREAplAAhhERL.pEK-c+h.tEVR+sKE.p..................................	0	26	39	74
+4526	PF02116	STE2		Fungal pheromone mating factor STE2 GPCR	Mian N, Bateman A	anon	IPR000366	Family	\N	26.20	26.20	26.30	26.20	25.50	26.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.94	0.70	-5.37	19	170	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	139	1	88	160	0	273.90	32	65.70	CHANGED	asPhpphlsapts....G.sshslshsplsphlppplphuIhaGsplGAs.llhlllLhhlo+sc....+oslFllNpsuLhhshl+usL.htYhhusasul.hhhTu.hphlopsshtspsAuslhpslLlssIEhSLlhQlpVlaps.s.+hhthhLhulSshlulssluhhhssslpshh....slhssssst.shhah.....slssIlhusSIsFhohlLlsKLhhAI+pRRhLGL+QFsuh+ILhIMusQTlllPS...........ILhIlpY..hssh..spLssluhhLVsLSLPLSSlWAu	..............sPhpQslshhts.....G..s.hsl....shstl-shhp.tlphsIsausplGAs.hlhL.llhh.h.hopscc..h..........+s.lFllNhluLhlsllRssLhhhahho.sass....hhhhaoGsa..ph...lstu.shpsSlAusllplllsshlEsSLhhQshlhhps..hs....phh+..hhlsslShllulssluhphssslhpsh..................slhp....s..ss....hs.....hh.Wl..................phshIlhssSIsaaohlhssKLlh.A.lhoR...R.hL..Gh.Kp.F.suhclLlIMusQohllPu............lhslLpa.h.ss....s.phsolshslVllsLPLSSlWAt..................................................	0	14	42	72
+4527	PF02076	STE3		Pheromone A receptor	Mian N, Bateman A	anon	IPR001499	Family	\N	24.90	24.90	25.50	26.70	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.92	0.70	-5.32	50	604	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	245	0	180	590	1	238.10	28	69.11	CHANGED	sshuhluhlLslhPLsWHh+u+NsushhlhhWhhlssLpphlNullWssss.ts.hhs..saCDIss+lhlGuslulPuuslCIs+pLtpIhsscpsphstspp..p+plhhDlhlslhhPllhMuLpalVQuaRasIhcthGChsshhsohsuhhlhahWslllulluslYusLsLhtFh++RtQFsslLpsspSuLohuRahRLhhLuhl.hlhhhPlshaslh..lphppss....hsa.SWspsHss...a.spI.paP.............hsplhhsRWlssssuhlhFhhFG....hup-........AhphY	.............................h..hh....h.hhh.st..s.ush...hhhhWhhlhsl.thlNullW.sss..hs.hhP...sWCDI..s..........s+.lhhus.slG.lssush..CIsRpLt.p.Iss....s.ct.s.t.hotpc+................+Rp..hhhDhhlslGlPllhhsL.......phllQspRasIhcthGChsshh.ohsshhlhhhWs.hlhuhsuslYus...lslhhhhp+..Rtph.pphlts.s....Ss.l..s..h.s.Ra..h....R....Lhhhshh.lhh.hhPhshh.hh..h.............a.sat.hH........h..t...l..hs..................h........h....h.shhhh.hhFu.hs.-s...Y........................................	0	99	134	164
+4529	PF04885	Stig1		Stigma-specific protein, Stig1	Mifsud W	anon	Pfam-B_6528 (release 7.6)	Family	This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone [1].	21.90	21.90	22.00	21.90	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.49	0.71	-12.08	0.71	-3.97	14	196	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	43	0	144	189	4	94.50	32	43.63	CHANGED	llhlllslslphhshsssssss............p..tppspssshhssspss..ssh..ut....................pCsp..sstICpsst.....ssphsCCpN.+CVDltosctNCGsCsptCca.up.pCCsG.CVslthDpppCGpCsppCt.Gp.CsaGhCsYA	..............................................................................................hh.........................................................................................................................................sC.....t...........C.hsh........s..pCGhCsp.tC.ph.u.p.pCC..sGt.C...Vs...ltsD.ppCGtCsp..........tCstGphChhGhCs..............	0	50	108	135
+4530	PF05217	STOP		STOP protein	Moxon SJ	anon	Pfam-B_6629 (release 7.7)	Family	Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable  microtubules are thought to be essential for neuronal development, maintenance, and function. STOP is a major factor responsible for the  intriguing stability properties of neuronal microtubules and is important  for synaptic plasticity. Additionally knowledge of STOPs function and properties may help in the treatment of neuroleptics in illnesses such as schizophrenia, currently thought to result from synaptic defects [1].	27.00	27.00	27.20	27.20	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.79	0.70	-4.60	20	445	2009-01-15 18:05:59	2003-04-07 12:59:11	7	11	81	0	305	392	1	156.10	15	61.31	CHANGED	ut..ClCplCsCu+p..hCp..ppslplslshphh.......SsYcp-a............sspssptss.hsttchps+thsl....................osYppDFphhsh........stpccsh.tpshshsupouYsosa.shss.ssspht.sp.hsshs..hshsspToY+p-Fp.shpt.....sshsscsp.tpthss.....a.s.o............appsapspssssht..................................thppchshssos.Fpuph..........pphca	.........................................................t.....................................................................othtpp............................................................................................................................................osh+.pDatsapht.....t.hp..p.p.p.h.t..sss.s..F.pstTo...a......ppcahs..h...th........h.....t...sh.+s.t......h....s...hPhp.s.o............sa+.pah..s....................................................................................................................................................................................................	0	134	160	207
+4531	PF03088	Str_synth		Strictosidine synthase	Griffiths-Jones SR	anon	Pfam-B_1533 (release 6.5)	Family	Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid  biosynthesis.  It catalyses the condensation of tryptamine with  secologanin to form strictosidine.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.69	0.72	-3.95	8	707	2012-10-05 17:30:42	2003-04-07 12:59:11	11	11	260	14	391	1067	163	85.90	36	22.65	CHANGED	sulsVssp.GVlYFTDuSo+Ysh.+plhhshLpGcssGRLh+aDPoT+sT+VLLccLaFsNGlulSsDpoallhsEsshpphh+Yalpts	.............................................sslslsps.GplYFTDo.........S.........s...........c..........aph....c..............p.......a........h....hsh...........h..p...u.......c.s.sG..R.Ll+YD...............s.p..T.pps.pVL.lcs.Lt.FsNGVulSsDpsa.......ll....lsETsttR.lh+YalpG....................	1	98	227	319
+4532	PF04270	Strep_his_triad	strep_his_triad; 	Streptococcal histidine triad protein 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	All members of this family are proteins from Streptococcal species.  The proteins are characterised by having a HxxHxH motif that usually occurs multiple times throughout the protein.	20.90	20.90	21.30	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.58	0.72	-4.24	5	2985	2009-01-15 18:05:59	2003-04-07 12:59:11	8	20	316	3	93	1739	0	48.40	47	18.71	CHANGED	YTT-DGYIFsPsDII-DpGDAYlVPHGsHYHYIPKc-LSsSELAAAQAYhupK	..........sDGYlFs.PscIlp-.s....u.....s.ualVPH..G..sHaHaIPKspLSt..E.hthAp...................................	0	21	31	53
+4533	PF02516	STT3		Oligosaccharyl transferase STT3 subunit	Bashton M, Bateman A	anon	Pfam-B_1095 (release 5.4)	Family	This family consists of the oligosaccharyl transferase STT3 subunit and related proteins.  The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for its activity [2].  In eukaryotes, OTase transfers a lipid-linked core-oligosaccharide to selected asparagine residues in the ER [2]. In the archaea STT3 occurs alone, rather than in an OTase complex, and is required for N-glycosylation of asparagines [3-4].	27.90	27.90	27.90	28.10	26.90	27.70	hmmbuild  -o /dev/null HMM SEED	483	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.93	0.70	-5.53	15	968	2012-10-03 03:08:05	2003-04-07 12:59:11	9	12	617	11	541	870	126	459.70	26	63.95	CHANGED	hltlllhuhhhhssshuc.........lFsstphhshh.-hDsYYpaRlsctllpcGa........hsthsaa.pptaYPhG.hlsassllshL.hshhsllhhhhs......hslpplshhhsPlluulsuIssahLs..+clpsctsGlluAhlluluPu.YlsRoluGha..Ds-hhslhlhhhshhhalcuh+sus............hhassluuLshhlhshuWsGh..........lhhhshhsLhllshLlhu+..........apschhhlh...............shshllssls..hl.hshlGat.........hhthhhlhulhphhshsshstt............hhshhpats.....lhhsu.lsplsslh..ssslhsluhhGhlu.h..................sGhhaslhp..........hschpl.hls.ls.apshuhhuhhhul+Fh.lhshPlsl...hasshhlcshtshhhhhu.....................hhthhhssshsh.lhlslssslshlushths.tlhsphhtpttsth+h.....t..........................................ssssssllhstasashhhhshtsp.....Vshsuhu	.....................................................................h...h..h.hhhhh...h....h...............hhs..h..h.h...a..........h..hp....EF.DPa.F..paR.tsphlspp..Ga................athhsaFD.t..............saaP...hG...h..l..h..h..G.....o..h..h....s.s..L......h...h..ssth..lh.h.hhp.................hpl.t.s.ls..l..a....h..ush.huu.lss.l.s.sa...hls.....cch.................t......s........s...........t........u........G....l...lAAhhhul.sP...............u.YlsRSh.uG.a..Ds-sl..s.I...h...h...h.h...h.s..h...a...h.a..l...+.ulcpss.................................................hh.a..u..shs..uLshh...h.h..l.u..W.uGa..........................sallsll.s..L..a.shhh.l...l..h.tR...................................................................hsp..pla...huh.................................shh.hhl...shlh.......s.ht..l..sFlu...Ftshp.........s.pth..u.........s..hu...l..h.sl.l...t..l..h..h....h..hthh.t................................tlshttaps.........................lhhhh.....hhh.shhhh........hhslhhls..h.h..uh..lu..s.h..............................................................................................................suhh.hSLhs...............sasp.h...p.h.shh.s.sls.at...s.s..s.......a.uh..hhs...lp..hh....l....hhhP.s.ul..........hhs..h....h...h.......p...........t....p...l.hl.hhhu........................................................................hhs..hhhsssh.l.h..lh..Ls....L..sP..s.....h...s.h...h.....u..u....hshs.....p...........lhs......p...h.....h.t...t.....t...p.......................................................................................................................................................................................................................................................t.s.......ps.h............lh.s.hhshhh..hhhhtsph....shsp...................................................................................................................................................................................................................................................	0	184	311	447
+4534	PF03481	SUA5		Putative GTP-binding controlling metal-binding	Bateman A	anon	Bateman A	Domain	Structural investigation of this domain suggests that it might be a GTP-binding region that regulates metal binding and involves hydrolysis of ATP to AMP. It is found to the C-terminus of Pfam:PF01300.	22.90	22.90	23.00	23.20	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-11.20	0.71	-4.04	384	2044	2012-10-03 16:42:30	2003-04-07 12:59:11	8	11	2016	4	615	1629	1172	136.70	28	39.29	CHANGED	lohEp..lc..pllGt...........h........t..t......t....sp..tP.........p.APGMhhpHYAPputl........h..ls........p.................th...pt.............................................sptlhhlshst......................................htt...........s................hsh...........usptchppsApsLFssLRphDp...........p......sh.chIhsp........s..hs.p....p...Gl..G.tAIhsRLp+A.Au	............................................lTh-plcpllGp.......................th.h........pc..............sp...tP.c.APGMKYpHYAPc.sslhll..p.....................sh....t........p..............................................................spclullshpph................................................................................htth......t..........hhh........h...........ustschpp.sApsLassLRphDc..............p....sl.chI..hsp........................s.hs....p...s.....sl.G...tAlhNRLpKAAu............................	0	225	402	517
+4535	PF01300	Sua5_yciO_yrdC		Telomere recombination	Finn RD, Bateman A	anon	Prosite	Family	This domain has been shown to bind preferentially to dsRNA [1]. The domain is found in SUA5 Swiss:P32579 as well as HypF and YrdC Swiss:P45748. It has also been shown to be required for telomere recombniation in yeast.	22.80	22.80	22.80	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.11	0.71	-5.03	163	8425	2009-01-15 18:05:59	2003-04-07 12:59:11	13	39	4856	15	2171	6104	3104	175.00	27	51.50	CHANGED	phLcpGtllAhPT-osYuLuscst.sppAlp+lhphKpRs..sK..Plslhss.....slpp..lpphst...th.......spthhp............hhpp....hhPGPlTllhph..................pp.......lsp..hl.............sstsslGlRlPspsltttLhc..................th.t.....s...........lluTSANhSG.c...sss.tsspclhpp.l....sstlD.......hllcss........hh.tshsSTll..c.lh......t.p......l.lRpG	........................................t.hlppGtlluhPT-os.YuL..u.......scst..........s...........p.......pA..........l..........p+lhphKp.R.P..t.........s+.........slhlhss........shpp..l.pp.asp......h..........................s.s.t.h.hc.....................................lh..ps.....h.......h....P.......G...PlTh..lltt.....................................tpp......lsp...hl...................ss.s.h.so....lulR....l.....Psp.P..lshtLlp.........................................................th.u.t...P...................lsuo..SA.N....l.S.G.p............ss.s....p..s....s.p......c...l.hpc...L..........s.s..p..l.c......................h.l.l.cu.......s............ht.......t......t..........h.s........STll..Dhs.......st.st.....l.lRtG.........................................................	0	706	1382	1838
+4536	PF00862	Sucrose_synth		Sucrose synthase	Bateman A	anon	Pfam-B_484 (release 3.0)	Family	Sucrose synthases catalyse the synthesis of sucrose from UDP-glucose and fructose. This family includes the bulk of the sucrose synthase protein.  However the carboxyl terminal region of the sucrose synthases belongs to the glycosyl transferase family Pfam:PF00534.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	550	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.61	0.70	-6.54	4	604	2012-10-03 16:42:30	2003-04-07 12:59:11	14	9	221	27	131	815	109	398.90	57	63.47	CHANGED	TRVHSlRERls-TLoAHRNElLuLLSRh.upGKGILQPHQLlsEaEsI..tED+tKLcD..GsFu-Vl+SsQEAIVlPPWVALAlRPRPGVWEYVRVNVacLsVEELoVsEYLpFKEELV-GSSsuNFlLELDFEPFNASFPRPTLoKSIGNGVQFLNRHLSuKhFHsK-ShaPLL-FLRlHsYpG+oLMLNDRIQslsuLQusLRKA--YLuoLPsDTPYSEFEH+FQElGhERGWGDsAcRVhE.hHLLLDLLEAPDPsTLETFLG+IPMVFNVVILSPHGYFAQsNVLGYPDTGGQVVYILDQVRALEsEMLhRIKpQGLDIsPRILIVTRLLPDAVGTTCsQRLEKVhGTEHoHILRVPFRTEKGILRKWISRFEVWPYLETasEDVApElAtELQupPDLIIGNYSDGNLVASLLAHKLGVTQCTIAHALEKTKYP-SDIYWKKFEc+YHFSCQFTADLIAMNHsDFIITSTFQEIAGSKDTVGQYESHTAFTLPGLYRVVHGIDVFDPKFNIVSPGADhoIYFPYoEpEKRLTuLHPEIEELLYS	..............................................................................................................................h...h.........................h..hh...pEhhh.s..hhhhhR..p.u..phhplp..th.h-.h...ph.Lth+-thh.t.........p....t....L.El..DFtsFp..hPp.p.sp.IGpGhpals+ahou.hh..t...p...p......h....Lhta.L..hph......p...G........hhls.pp.lps..tLp..lhhA..hl.th..ppsatpht.p........hpthGhE.GWGssAt+s.p.hphL.-llpuP-.s.shEtFhuplPhhF.....plVlhSsHGaF.u..Q..ts..V.L..Gh.PDTGGQ........VVYILDQVRAL.Ep.E.h.l.R...l.....c.......Q..GL.....s...l.....h.P+I....l.....l...l....T.R.L.l.P.-..A..h...GT..s..C..s......Q..+..L..E..cl........G..o...c.......t..s.pIL.RVPF+s.pp.G.h.lcpWISRF-.lWPYLE.p.as...c.............D...........s...........s...........t..........E....l...........h.......t...........Eh...........p......u...........p...........P.D...L..I.lGNYSDGNlVAoLLup+LsVTp.........C.......sIAHAL...EK...T...K...YP.......c....SDI...Y....W+...c....h...--KYHFSCQFTADLhAMNpoDFIITSTaQEIAGSK-oVGQYESHtAFTL..P.G.L.Y.RVV.HGIDVFDPKFNIVSPGAD.slYFPYT-pc.c.RLTshHscIEELLas...........................................................	0	25	79	113
+4537	PF02657	SufE	UPF0050;	Fe-S metabolism associated domain	Bashton M, Bateman A	anon	COG2166	Family	This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export [1]).	20.20	20.20	20.20	20.40	20.10	19.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.31	0.71	-4.49	7	2432	2012-10-01 20:52:23	2003-04-07 12:59:11	10	5	1792	5	531	1474	985	125.00	36	81.81	CHANGED	lhppF.cstph-c+Yc.LlphGppLsshscchhtptp..l.GCpSplal.htshpssth..hF.u.o-AhlspGlhullhphhsGpTss-Ilshssh.FFpcLult.pLS.uR.pGhpulhtthpphsh	.........................................hpsFt.hssWE-+YchlIpLGcpLP.sLs..-...c...h..+...s...p...t...pp...l...pGCpSp.V..Wl............h....h.....p......p....s.........p....s.......G........p...l........cF..p.....G..D..SD..A.t...IV+.........GLlAlllt...hh........sG.pTsp-lhshc...s....p.sa.Fccl..GL...p.p.p.L...S..PoRopGLpAhlctI+stA.t...............................	1	147	317	440
+4538	PF05076	SUFU		Suppressor of fused protein (SUFU)	Moxon SJ	anon	Pfam-B_6089 (release 7.7)	Family	SUFU, encoding the human orthologue of Drosophila suppressor of fused,  appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus [1]. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway [2]. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems [3]. 	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-11.15	0.71	-4.68	132	954	2009-09-17 14:43:38	2003-04-07 12:59:11	8	30	737	5	252	788	16	163.50	19	53.36	CHANGED	ts.ssh.slslhhhts..t.......pshhphlThGhS..............................th.ht..sp........phhthELhhtl.................spp.hashphLt...........slA.phshp....pss...h..l....s.Gphl..................s..psht....tso.....phsuhhlhts......hhtssphsth.............stt.......lpahpllPlppsEhpahp....ppG...scsL.hpth..tpt.....shtlhDhpRps	............................................................................................................s.......lslhth.s.............shhpasThGho.................................th.ht....tt.......t.pththELhhtl...................ptt..hhhp.hLt...........slA..phshp....ptp..h...h..............s.Gphl..........................s..pshs........tss...phsthlhs.s......hhtssp.h.sth...................stt................Vpal.llPlsppEhphhp.......ppG........hps..l..hchh..ppt.....shplhDhpR.........................................	0	80	153	211
+4539	PF04198	Sugar-bind		Putative sugar-binding domain	Bateman A	anon	Pfam-B_1085 (release 7.3)	Domain	This probable domain is found in bacterial transcriptional regulators such as DeoR and SorC. These proteins have an amino-terminal helix-turn-helix Pfam:PF00325 that binds to DNA. This domain is probably the ligand regulator binding region.  SorC is regulated by sorbose and other members of this family are likely to be regulated by other sugar substrates.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.22	0.70	-5.48	31	3935	2012-10-04 00:26:15	2003-04-07 12:59:11	8	27	2304	24	585	2201	210	247.90	26	76.87	CHANGED	sphssshcLEptLcc+auLccshVV..Psss.....st..sss.hpplutsuuphlpp.hlp.ssp..lluluhGcTltssscthss..hphpslphVshhGGhst...hs.hps...lstphAc+h.supsthh.sPshhsssphtcslhpptslpsllphhcpsDlslhGIGshtp..puthhtpshhspp-hppl.pptuuVG-lhGt.aFDtpGphlp.tshss+slulpl-pL+phsphlulAuGppKspAIhAAL+us.hls.sLlTDEpoAptlLs	.....................................................t.hplEppLpc+a...u.LpcshV..l.......s..sps.................sp.....tsh..tpplup.suAphLpp..hlp...ssp..........llul.u.aGp.T.......ltsls..c.p.l....ss.........h.....p.h..p..p..l..p....h.....Vsh........t.......G.......Gh......u......p......tht...hp.ss..p.ls.tphApph..su.p.s.p.hl.sPhh.hsssp.......htpslh.pcpslpplh.phhpp.....uclulhGIGshtp.....puth.h....ps.h.h.s.p.....p-.h.......p.p.l.tppsAVG.-lhuh.FaDtcGphlp...thpp+...slGlsL.pp.Lc..........p..........h.....sph.lulA..uGppK.s.pAIh.............uuL+....us..hls..sLlTDpssAptlL.............................	0	153	343	458
+4540	PF00083	Sugar_tr	sugar_tr; 	Sugar (and other) transporter	Sonnhammer ELL	anon	Prosite hmmls-iteration	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.46	0.70	-5.91	44	32448	2012-10-03 03:33:39	2003-04-07 12:59:11	19	163	3323	0	14571	74553	5580	356.20	18	81.17	CHANGED	hshhsuhuG.hhFGaDsGhIuuhhthhshhhpas.htpppssth.................................................................p.h.ulhVuhh.lGshlGulhsuhhuctaGR+.hullh.ssllhllGsllpshup..........shhhlhlG........RllhGlulGhhsshsPhaluElA...PpplR.GslsshhQLhl.shGIhluhhhshsh.tthss.........tW+l.lulshl.ulhhhhsh.halPESPRaL.l.psch-.cAcpsLt+...hpt.....t.ss.pltc.hsphpts.t.t......hshtplhpths...hh..lhhuhhlphhQQhoGhNslhYYusslFpslGhsss...hhsolllG.llNhshThlu.l...ahl-+hGRR.......phhLhG.......hsshshshhhhs....sshhhsss........phhuhshlshhhhalshFshuhuPlsallsuEhFP.psRstuhulAsssNW..lhsFlluhhhPhhtssls.......hhshhlFsuhhlhhhhasaahlPETKGholEclspha	.................................................................................................................................................................h...........h.......h..h.....s.............h....h......s........h................................................................................................................................................................................................................................................h.....h..h...u..h.....h........h....l..u.....t.....h.....l.....G...u...h.........h........h.......G..........h............h.......u......D........+...........h.........G....R.............+....h................s...........h......h.h....s....h.h...h.....h.........h..........h..u..s....h..h........u..h.ss......................................sh.h.h..l...h..hh............................R...h.l...........G.....h...........u.......h.......G......s.........t...............h......s...................s......s.........s...................h......h.....h........s.........E....h...u.....................s.....t....p.......h....R......G....h......h............s...............s.......h.....................p....h......h.......h.......s.........h..............G....h.........h......h....u..........h........h......h.....s....h......h..h.......h.s.................................................W......R....h.......h....h.........h....s.....h.....l....................s......l.....l....h.....h.......h............h....h.....h......h.....l.....s........E...S.......P...t....a.....h.....h................p.........t.........p........................t........p....u.............t.........h...tt..............................................................................h.............t...........................................................................................h............h..h................................h...h......h....h.....h....h.....h..................h........h.......................h...............h....................................................h..................h.........h.................h.........h..................s....................h.........h........t............h......t........h..t............................hh...hs......h.....h......h............h........h....................h....h......h.....h....h....h...s...h...........................hh....h.....c.........p.........h..........G.......R....+..................................h....h....h.....h.....s..................................h..h...h...h...h....h......h.h...h..h.h.........................h..tt..................................................h.....h.....h.....h...h..h...h....h.......h...h....h....h....h....h........t..................s.............................s............s..........h........................h....h......h.........s.......E....h...........h...s............t.....h.....R.............s.......u...h.....u....h.....s....h......................h.................t..h.................h....h.....s.....h........h.....h.......s.....h.....h..h..............h....h.....t.......h.t.............................................h...h...h...h......h..h.....h...h..............h....h......h....h.....h....h.........h......h....h...h......-.s........t....................................................................................................................................................................................................................................................................................................................	0	3767	7345	11757
+4541	PF01253	SUI1		Translation initiation factor SUI1	Finn RD, Bateman A	anon	Prosite	Domain	\N	25.50	25.50	25.50	25.60	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.91	0.72	-4.18	161	2651	2009-01-15 18:05:59	2003-04-07 12:59:11	17	21	1783	5	1143	2005	478	80.00	33	45.58	CHANGED	ttppthl.....+lphp......p+.pts...........KtVThl...pG.ls..h.tth............-lcpluKpLKpchusG.Gol...................t...sp.IplQGDppcp.lhp....hL...cpshtscp	...............................s..tpshl.....+Iphp.............pt.pts...........KsVThl...pG.ls.......h.p-h............-LccLu.ppLKK+huCG.GoV...................+..st.IplQ.GDpRcp.lpp....hLtpc.Ghthp................	0	338	612	910
+4542	PF03846	SulA		Cell division inhibitor SulA	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	30.00	30.00	30.10	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.82	0.71	-4.41	9	642	2009-09-10 23:49:51	2003-04-07 12:59:11	9	1	637	6	70	245	12	111.40	62	68.04	CHANGED	hpShass+usptShssppsupsssttsssGLISElVYpEDQPhhTQL.LLPLLQQLGpQSRW.LWLTPQQKLSRpWVQpSGLPLsKVhQlSQlsPhpTV-uM.RALpTGNYSVVlGWLs	....................................a.pStasp+uspasssspphAc.suspsssuGLlSElVY+EDQ.........PMMsQL.LLLPLLQQLG..Q..Q..SRWQLWLTPQQKLSREWVQuSGLPLTKVMQISQLuPpHTVESMlRALRTGNYSVVIGWL.............	0	5	17	43
+4543	PF00916	Sulfate_transp		Sulfate transporter family	Bateman A	anon	Pfam-B_223 (release 3.0)	Family	Mutations in Swiss:P50443 lead to several human diseases.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.58	0.70	-5.40	34	7799	2012-10-03 01:44:59	2003-04-07 12:59:11	15	65	2994	0	2983	6879	2252	253.50	24	45.21	CHANGED	hGlhRLGhllcalScsllsGFhuGsAlhIhlpQlcslhGlp....sppsthhslhpulhp.hpp..............hph.shlhuh.hLhhLhhhphls.....h......thhhhsssssLlsllluThhshhh........ptcthslshlGclssG..lsshslsp....hshshltphh.huhshullulhEulhsucshuthpshpl.DuN+EhlAhGhsNlluuhhushsuoGuhuRSslNhp.uGs+TtlSslltulhlllsllhlsslhthlPhulLuulllhsshu.Lhchpphhp..la+ls+hDhll	...................................................................................................................................hGhh+.l...Ghlh.p.a.lstsV.lhGF..hsulul.hI...hh..sQ.......ltt..h.h.....G.ht...........................t......t...h.....h.........t...........h.h.....t....s....l.h.......h..t.................................t.......s...h...h...h....u...h....h..s...l.h..h..l...h..h...h..h.hhs....................................................h..h..h...h...h..h...P...s.s.L...l..s..l.l.h......s...s.h.hshhh........................hhp.h.......s.l...s.....h......h.........G......p......l......s......su..........l.s.......s......h.......t.......h..P..........................h...............s.................h............p.................h............l.........t......t......l.....h..s.....s....u..h.....s........l.A...h....lu..h...l.........E...o...l.h..s............u....p..s....h......s......t.....h.............p......s......t..............p........h...s....s.........N...p...Eh..l.u..........Gl...u.Nlh...u...uh...h.u.u.h.s...ss.uuhuRos..........lNhp.u.G..........u+...o....t................luulhtu...lh.l....l...l....h.l.l..h....h.s....s....l..h..t.h...l....P.....h.us.Luulllhsshs.hh.c.h..p..p.h.h.t..hh.+.h.st.-h.......................................................................	0	855	1655	2449
+4544	PF03856	SUN		Beta-glucosidase (SUN family)	Finn RD	anon	DOMO:DM02469;	Family	Members of this family include Nca3, Sun4 and Sim1. This is a family of yeast proteins, involved in a diverse set of functions (DNA replication, aging,  mitochondrial biogenesis and cell septation)[1]. BGLA from Candida wickerhamii has been characterised as a Beta-glucosidase EC:3.2.1.21.	25.00	25.00	82.40	81.70	17.00	22.30	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.11	0.70	-5.08	50	297	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	121	0	204	287	0	247.20	45	59.94	CHANGED	tDGshsCupF..Posp.Gllulsalu...GGWoul...hs...............s...sussCpcGsYCSYAC.sGhsKoQW.Po.sQsosGtSl.GGLhC+.sGpLa+oNss.tchLCt.GsG..sspspNpl.upsVAlCRTDYPGoEsMlIPThVsuG.s.psLoVsDtssYYpWpGhtTSAQ........YYVNssGVSsE-GClWGosuss..lGNWAPlshGA...Ghss.GhoaLSlh.N........Ps.spst.sFslKIhusssss.luGsCpY-..sGsasu...........sGusGCTV	.....cGshsCupF..Posp..Gsluls.alu...GGWusl...hs.................s...supsCpsGsYCSYAC.PGhtKoQW..PS..sQsosGpSl.GGLaCc.sGpLh+osss..c.LC.tGsG..usp..shNch..up.sVAhCpTDYPGsEsMlIPThVsuG.sotsLsVscpss..YahWpG..TSAQ........YYVNssGVSs-DuClWG........o.s..u.ss..lGNWAPhshGAGhss.....G.tT......alSlh.N........Ps.s.sst.sFsl+Isusssus.lsusCph-.....sGsasu...............sGusGCTV.............	0	29	95	169
+4545	PF03439	Spt5-NGN	Supt5;	Early transcription elongation factor of RNA pol II, NGN section	Bateman A	anon	Bateman A	Family	Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4 [1].  Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit [2].	20.20	20.10	20.20	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.70	0.72	-4.23	64	521	2012-10-02 20:41:53	2003-04-07 12:59:11	8	26	429	5	355	529	81	83.80	32	11.04	CHANGED	slauV+s.psGpE+slshhlhp+.....ppps.......l.pIh..Slhssss....lcGYlalEAppp.sslppslpulhplpsh..........th..lslcEh.chL	..........plWsV+C.phGcE+plshtlhpKh.th.tssp.......l.pIhSlhs.-p.....lKGYIYlEA.+p.scVcpAlcGlsslhhth..............th..VPlcEhsclL............	0	111	199	297
+4546	PF01975	SurE		Survival protein SurE	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase [1].  It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family Swiss:P38254.  Swiss:P30887 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.	20.90	20.90	21.20	21.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.54	0.71	-5.01	133	3045	2009-09-11 04:46:26	2003-04-07 12:59:11	12	9	2646	51	1005	2370	1174	189.50	39	68.06	CHANGED	M+ILlTNDDGl....pAsGlpsLhcsL.pph...t.-..VhVVAPcpppSusupulTlpcPL+l.pph.............................h......haul..s.GTPsDCVtlulptl.h.tp...............P..DL..VlSGINpGsNlGpD.lhYSGTVuAAhEushhGlPuIAl....Shssp.........................t...............a....phAsphstpl.lpplh.ppsh.s........t....sslLNlNl..Ps......hs.hppl..pGl+lT+hGp+.tatpp	.....................................+ILloNDDGl........pAsGlpsLtcsL..cph................s-....VhVVAP-.............p.s.+.SG....s.Sp.u....l.T...L...pp...P....L+.h.pht............................................................................ttta.ul..sGTPsDCVhlulssl..hpt....................PDl..VlSGINtG.sNl..GcD....llYSGT....VuA.AhEGt.h.h.G..lPA.lA..l.Shssp....................................................t.........c....a....csAup....h....s....ppl..lpplh.....pps....l....s..........s...........splLNlNl....Ps.......hs...hppl.......+Gl+lT+hGp+t...pt........................................................	0	297	627	859
+4547	PF02104	SURF1		SURF1 family	Mian N, Bateman A	anon	IPR002994	Family	\N	20.80	20.80	20.90	21.00	20.70	19.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.82	0.70	-4.50	181	1742	2009-09-11 11:18:05	2003-04-07 12:59:11	10	8	1323	0	681	1517	1849	208.90	23	76.92	CHANGED	s......lhshslhls.LGhWQlpRhp.Kpsll.splppphp...s.sPl.slsth................t.............................................................pappVpls.Gpahsppphhlt.spsp.......p...................st........sGa....hVlsPhphs.........su.........phlLVsRGal.s..........t.tst............s......................................s..lplsGhl+......sp.h.tt.hh.............ts..s.t..sphhhs.........hDlst....hu.....pthsh..........htPhhlp....................................................................................................s..sh........shhp.........hsspHhsYAlpW..F..............uLAhh	...............................h.hhhhshhht..LGhWQl.pRhp...K....pphh....splp...pp..hp....t..sPl..slsph...................ts....................................................................................................................................paR+Vpls.Gpa.s.s.pp.hhlt..spsh................p.............................sp.....sGa....hVlTPhphs.........sG................phl..LVsRGal.st...p..t.s.ts......t........s..............................................................Gp.lsl..sGhl+..........spst.....t.hh.......................ts.....sss.....tthhht.............hch..s.t....hu.................p.thGh.............lts.h.h.lphstp.............................................................................................t.ss..........lss.......shhs.....................hsspHhuYAlpWauhuh..............................................................................	0	198	411	560
+4548	PF02077	SURF4		SURF4 family	Mian N, Bateman A	anon	IPR002995	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.74	0.70	-5.03	6	375	2012-10-02 13:32:46	2003-04-07 12:59:11	10	12	249	0	240	803	568	224.50	40	84.33	CHANGED	N-hhu+sEDhAE.shh+ps+sYLPpluRLhLluTFhEDGlRhhhQWs-QhpYhspsWshsaahAslFllVsllu.LhGsshVhhRp+VshAsGlLhhlllLQslAYullhshcFLhRNhullGGLLLllAEohlcp+o..hFAGlPshs-..scsKsYh.LAGRVLLlhMFloLl+F-...hSahpll.sIlGsshhlhVsIGaKTKhuAlhLVlhLhshNlhlNuaWolPpppshRDFlKYDFFQTLSlIGGLLLllshGPGtlShDE+KKcW	.......................................................................................tphE-hh-...ph.c.hK.aLPtluRhhllsTFhEDulRhhhQWs-Qh.Ylpth..hp.........h.....shhls..p..hFlhlNllu.lsusshl...lhRp..hsphAshsLhsllhh.QsluY...u.l..l.....a....D..h...pF......hhRN.lul.hG.GLLlllu.-.....Shsct+p......hF...A..G..lPp.ht-.....pp.KtYh.LuGRlLLlh..hFh.....s.....h.lh.....p....................ho.h..h.......p.........l........l.............s.l.....lG.h...h...h.......h....l........hVsl.Ga.K....sKh...uAhhLV........lh.L.hhN.l.h.h.NsaW....s.........h..............cs.h.+D..FhKY.D.FFQ.sl...Sl.lGGLLLlVshGPGtlShDE+..KK.a.............................	0	72	116	186
+4549	PF01617	Surface_Ag_2		Surface antigen	Bateman A	anon	Pfam-B_1042 (release 4.1)	Family	This family includes a number of bacterial surface antigens expressed on the surface of pathogens.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  --amino -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.63	0.70	-5.17	10	3846	2012-10-03 17:14:37	2003-04-07 12:59:11	12	3	1018	0	167	4193	20	149.70	31	84.65	CHANGED	ssuGuFYIuscYsPuhupFssFSscEs.....ps.TpsVFGlKpDhsshshspststs....Fs..sYshpapsN.FhGFuGAIGYuMsGsRlElEsuYEpF-sK.....Np.......................................Gsshcs..............................................................DA+casALo+p..s....t.shsssphlhlcN-ulsshSlMLNuCYDlhpEGlPloPYlCAGVGuDhIS.....hhpshNPKhSYQG..KlGlSYsIoPElSlFsGG+YH+VlG.NcFc-Is.shpsssssssup....sthAtlTlsssaFGsElGsRFsF	.......................................................................................................................ss.............................................................................................................................................................................................................................h.u.......t.s...Rh-h-h.hp....h.h.......................................................................................................................................................................................................................................................................................................................................................................................................s..culss.hS...sh.lNshYD...l...h.h..-...s...h.......s..l...oPY.....l..ssGlG.........u..s..hls.........................h.hs..p.....t....t.....h..uatu..........KsGlSYp.l..o..Pclp.lasG......uhY...atshs..tp........a...t...........................................................................................................................................................................................................................................................................................................................	1	26	99	118
+4550	PF00084	Sushi	sushi; 	Sushi domain (SCR repeat)	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.70	17.00	20.70	17.00	20.60	16.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.52	0.72	-3.62	66	23751	2009-01-15 18:05:59	2003-04-07 12:59:11	15	763	241	368	12142	20429	36	57.10	26	31.65	CHANGED	Cs....P......h..s..ht.t.......spaphssplpapC.psGaph.tut......sthpC...t....supWsst......s.p..C	...........................................Cs....Ps...............pG....hp..........................ssaphG.s.p.lp..a...p..C..p.....s......G......a...pL..tGs.........................sphpC.........ts..........su..p...Woss........P.t...C....................	0	3225	3866	7035
+4551	PF04099	Sybindin		Sybindin-like family 	Wood V, Finn RD	anon	Pfam-B_3240 (release 7.3);	Family	Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses [1].	21.30	21.30	21.40	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.80	0.71	-4.48	11	676	2012-10-04 00:47:01	2003-04-07 12:59:11	7	13	308	17	471	982	9	142.70	28	83.69	CHANGED	lasLYlhN+uGsLla.p-appsh.t.............................................................................thsoNEpllluuhhaSl+uIsuplSP............h.up...........sGlchlEossF+LahhpThTGlKFlllT-sss.sth-sLl+hhY-LYoDaVlKNPFYsl-MPI+sELFcppLcphlcsh	.........................................................................................................laslalhs.+t.Gshla...pca..t.t...s...t...............................................................................................................t.h.s....ss-...thhl.huhha.........S..lpuhsppLo.P...............................................................................suh...p....h.c.T.spa...+...L.ah.a..pT...T....Gl..K....Fll.h..o......-.s.........t..............t.......................s...h.....h.....c.....s........L....h....p....h...h.h.plYs-a.....V..l..K..NPh....ap.....h......c.....h....P.....l...p.s.-.hFcpplpthlp.h..................................	0	156	257	389
+4552	PF02383	Syja_N		SacI homology domain	Mian N, Bateman A	anon	Pfam-B_1090 (release 5.2)	Family	This Pfam family represents a protein domain which shows homology to the yeast protein SacI Swiss:P32368. The SacI homology domain is most notably found at the amino terminal of the inositol  5'-phosphatase synaptojanin.	20.40	20.40	21.30	20.40	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.67	158	1561	2009-01-15 18:05:59	2003-04-07 12:59:11	13	28	323	1	1068	1526	19	302.60	26	34.15	CHANGED	saGllGllcl..ps........shaLlllTpp.ppVuplt............c.........sl..a.+lpssphls..lspsthp...................................................................................................................................................................................p....pphhphlcp...........lh....ps...ssFYFS.h..s.............aDLT.............pol.....Q.....ppttttt..........................................................th-.pcFhWNpalhpsl.hphp.........................................tsppalhslIpG.............................aspptphtls.........................................................................t..hplsLIoRRSpcRAGTRahpR.Glc-c..GpVANaVETEQIlh..................................s................................................................s....................................sphhSalQhRGSlPlaWpQ..s.....s..ht........hpPplpls.sh-ssh..tuhscHFppL.hppY....................GslhllNLl...........pp+spE..thLsptapptlphh................................p..tpp...........lp..ahtFDFHpp......s...pt..hchcs	.......................................................................................................................................................................................................hGllGhlph...t........................hallllTpp.pplu.p.lh.............c...................l...a.clpssphlslppsthp............................................................................................................................................................................................................ppp.hhphlpp...lh.......ts..ssF..YF....S..h......s...................aDlT.....................pshQ....cphttt......................................................................................................................................................tphc.pp.Fh....WNphl.hp..l..hpht.....................................................................................hppahl.sll...pG.............................ahp...t.p.h.ht.......................................................................................................................................tp.hthsLIoRRSpc...+.........AGsRa.hpRG.ls..cc..................GpV.ANhVETEQllh...............................................................................................................................................................................................p..............sphhS..a...lQ..........hR.GS..lPlaWpQ...ss...hp...............hpPp.lpl.....s......th......-s.sh......tuh.p.......pHFppl..hp.pY...............................u.h.h.llNLl..................pp+...stE....thLppt..apptlp.hh............................................t.ttp............................lpahtaDaHp.s+t.....p....................................................................................................................	1	394	614	887
+4553	PF02078	Synapsin	Synapsin; Synapsin_N; 	Synapsin, N-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR001359	Domain	\N	20.40	20.40	20.70	30.30	20.10	18.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.39	0.72	-3.91	4	232	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	91	20	115	258	0	96.20	58	19.27	CHANGED	sstR.s+lLLVID-PHTDWuKYF+GKKlhGDhDI+VEQAEFSELNLsAassGGhhVDMQVlRNGTKVVRSFKPDFVLlRQHAauMA.sEDaRsLlIGhQYuGlPS	...................s....p.+hLLVlD.-.pTDWuKhF+GKKlp.G-aDI+VEQAEFSElNLsAausG.uhsVDM...........pVhR.....NG....o...KVV....RS.F+PDFVLlRQHAauM.u.scDaRsLlIGLQYuGlPS....................	1	22	30	66
+4554	PF02750	Synapsin_C		Synapsin, ATP binding domain	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR001359	Domain	Ca dependent ATP binding in this ATP grasp fold.  Function unknown.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.35	0.71	-5.22	4	298	2012-10-10 13:17:03	2003-04-07 12:59:11	9	8	99	20	154	323	10	166.60	58	35.89	CHANGED	NSLaSlYNFCDKPWVFAQLlpIaKpLGsEcFPLIEQTaYPNHKEMLosPsFPVVVKlGHAHSGMGKVKV-NpHDFQDIASVVAlTKTYATsEPFIDuKYDIRVQKIGsNYKAYMRTSISGNWKsNTGSAMLEQIAMo-RYKLWVDoCSEhFGGLDICAVcAlHGKDGRDYIIEVhDSSMPLIGEHQ-ED+QLIsELVlsKMsQ	............................................NSL.SlYNFpsKPWVFuphlp.l.+pLG...............-pF.PLl-QTa...a...P...Na+........p..M.....l..o.h.sp....F..PVVVKhGHAHuGhGK..........l.KV-Nph.DF...QDI.uSVV.A.....hs.....p..T.......Ys..TsE..PFI.D..u.K.Y.....DlRlQKIGsN.Y..K.A.YM................RTSIS.G.NWKsN...T...G.S.AMLE.Q.lA.Mo.-RY....+l...WV.Ds.C..SEh..FGGLDICAVcAlHuK..DG+..DaI.h.E.....V.....h.....ssoMPLIG-pt.tED+pLIs-LV...ls+Ms.........................................	0	29	39	95
+4555	PF00957	Synaptobrevin	synaptobrevin; 	Synaptobrevin	Finn RD, Bateman A	anon	Pfam-B_303 (release 3.0)	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.66	0.72	-4.38	111	2176	2012-10-03 05:55:03	2003-04-07 12:59:11	16	31	380	40	1410	2035	37	80.20	29	38.98	CHANGED	ssc+lpplpsplcclpslMpcNl-.+llcRG-+l-tLsc+o-sLpssuppFcppupcL++phWW+Nh....KhhlllshllllllhlIllhhss	......................t..cpltplpsplc-Vps.......l.MpcNI.-.c...........V.L.cRGE+L-........p....L...s...-.......+o.-sLp.ss.u....p.pFc...ppApcl....p....pph..hhpp.h.......thhhhhhhhhhhhlhhh................................	0	499	779	1125
+4557	PF01284	MARVEL	Synaptophysin; 	Membrane-associating domain	Finn RD, Bateman A, Yeats C	anon	[1]	Domain	MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins [1]. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.	32.20	32.20	32.20	32.20	32.10	32.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.85	0.71	-4.37	93	2286	2012-10-03 17:26:12	2003-04-07 12:59:11	18	15	277	0	1320	2031	0	146.20	17	64.66	CHANGED	hhh..tsllRhhp...hlhu..lllhulsushh.......................................................htt..sthsashhsushshlh.shhhlls.h........hh.thshshlhhsh-hlsslhahsuhsshAsthps..................................................................tt....sttspptpAussFsahshhlahssshh	.........................................h......hhl+hhp....hlhu.llsauhh.ushh.................................................................st....s.s.....stp.a..hlhlush....salh...sl..hh...ll...h..hh.........hht.p...h...th.s...h..h..s...h.hh.ss.l..h..shh........a.h.s.ushhh.u.tt.hss................................................................................................t...h.sthtAu.........s.s..Fu..ahshhhahsshh............................................................................................................	0	214	413	813
+4558	PF01034	Syndecan		Syndecan domain	Finn RD, Bateman A	anon	Pfam-B_1182 (release 3.0)	Family	Syndecans are transmembrane heparin  sulfate  proteoglycans  which  are   implicated  in  the binding of extracellular matrix components  and growth factors.	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.17	0.72	-4.32	8	599	2009-09-13 18:19:46	2003-04-07 12:59:11	15	20	109	8	276	557	2	67.10	41	10.96	CHANGED	SpslhcRpEVL....AAVIAGGV.VGlLFAlhLVhFllYRM+KKDEGSYuL-EPK...u....Nuu.YQK.sss+EF	............s...............suhllGhV.suhhhsIhll..LahhY...+h..Rp+DEGSYpl-E...s+.......s.......................................................	0	38	59	144
+4559	PF01387	Synuclein		Synuclein	Bateman A	anon	[1]	Family	There are three types of synucleins in humans, these are called alpha, beta and gamma.  Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients. 	21.10	21.10	21.20	23.20	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.69	0.71	-4.24	4	229	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	66	9	81	186	0	111.10	60	94.74	CHANGED	MDVFhKGhShAKEGVVAAAEKTKQ...........GVsEAAEKTKEGVhYVGoKTKEGVVQuVsoVAEKTKEQAssVGGAVVouVssVApKTVEGAtNIAAAoGlVK+--hsp.....psPQEtstEsh.p...-P.sEuhEtspppG	.............MDVFMKGhShAKEGVVAAAEKTKQGVsEAAtKTKEGVhYVG...........oK..TKE.GVVpu..Vs.o.....VAEKTKEQsstVGsAVVouVssVApKTVEG...AtNIA.AATGlVKK-phsp......th.sppth.t.................................................	1	4	10	31
+4560	PF00837	T4_deiodinase		Iodothyronine deiodinase	Bateman A	anon	Pfam-B_1631 (release 2.1)	Family	Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.41	0.70	-5.36	4	345	2012-10-03 14:45:55	2003-04-07 12:59:11	12	5	107	0	155	377	21	150.70	28	86.45	CHANGED	LhhphLhsLlllPhFlusshhLhLLD.spl++Hllthtp+...................sPshshu-hs.RhhThpuL+sVW+uQhLDhaKps+.GGsAPNopVVplsGpc..................C+ILDFupGpRPLVLNFGSCTUPPFhu+hsAFpRLlpcapssADFLllYIEEAHPSDGWshssss...apI.pHQsLpDRlpAAplLLptA...PsCtVVsDTMsNsSstAYGAhFERLaVlQcG+IhYpGG+GP.uYplpElRsWLE+hp	................................................................................................................................................................................................hhhs.t.h..h....h.....p.h.p.ts...........Gt..APs...s.lh...tt....................................................................p....t..hp.hhlYltEAH.........s.........s.Dt....W..........................h..h......p.ps..p-Rh.hAp..h.....tt........................h..hhDth.ts.....at.....hh.......................................................................................................	0	50	60	90
+4561	PF03903	Phage_T4_gp36	T4_tail_gp36; 	Phage T4 tail fibre	Finn RD	anon	DOMO:DM03599;	Family	\N	27.30	27.30	27.80	27.70	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.32	0.70	-4.25	6	60	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	45	0	2	59	0	172.50	31	32.80	CHANGED	MADLKlGSTsGGSVIWHQGNFPLsPAGDDlLYKoFKIYoEYNKPQAsDNDFVSKANGGT....YtppVhFpcGlslsss...ssshsGIasGsGDGAoh-ssshclhSWhGIGFcsu.....ptsGsttlhhsspssphssRuslpus...hs.s.sP.ss.cLTRK..DY...VDusINTVTA.........NANSRVLRSGD..TMTGsLTAPNFFSQNPASQPSHVPRFDQIVIKDSVQDFGYY	.............................................MADLKhGoThGGs.lWpQGNhsL.PsusplhYKsa+.lYoE.sKPpA.s-..shVS.pusGGs...........h.t.lth...ppul..ph......stt..shhhuttsuss...........ts..sh..h.u..shuhtst...........ts..hhh...s.spss.httc.h...h.st................hthp..D....V.u.hshsst.........Nstph..ptss..shsG.L..sssphh..t................................................................................................................................................................	0	0	0	0
+4562	PF03906	Phage_T7_tail	Tail_fibre_T7; T7_tail_fibre; 	Phage T7 tail fibre protein	Finn RD	anon	DOMO:DM04804;	Family	The bacteriophage T7 tail complex consists of a conical  tail-tube surrounded by six kinked tail-fibres,  which are oligomers of the viral protein gp17.	21.20	21.20	21.20	21.80	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.83	0.71	-4.59	10	136	2009-09-10 23:06:56	2003-04-07 12:59:11	9	13	86	0	4	133	238	162.20	35	27.80	CHANGED	MAsT....ohhsYshsGosTsFsIsFE.....YLARpFVsVTLlu.....Dp+hLslNsD.YRFsssTTIohopA.hsPAsGasl.IEIRRhTusTDRLVDFsDGSlLRAhDLNlSQlQoLHlAEEARDhs.......ADoIGVssDGslDA+..GR+IVN.LAsussstDAVshtphp.shssosh	.............s...hhsaphDGsspsFslsFt.....YLs+p..VhVol.t......-pp..hsls.s-..Ypas..spsoIp..lspA......PA..s.........G......sp.lcl+RsTs..ssshLl-FscGShL.....puhDLshsphQshalApEut.Dhs..........................ss..sh.u.lssc..s.clDAc......uc+Iss.husshs.stDsssht.hp...................................................................................................................	0	1	2	4
+4563	PF02217	T_Ag_DNA_bind		Origin of replication binding protein	Bateman A	anon	Pfam-B_827 (release 5.2)	Domain	This domain of large T antigen binds to the SV40 origin of DNA replication [1]. 	25.00	25.00	34.90	34.50	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.25	0.72	-3.59	11	427	2012-10-02 18:54:06	2003-04-07 12:59:11	11	5	43	20	0	407	0	89.50	71	14.60	CHANGED	.DhPssLcuaLSpAlhoN+T.ssFLlaTTpEKsppLYspl......p+asspaphh.tpasssth.LallTss.+HRVSAVpNaCpKhCTVSFlhsKGVpKp	......KDFPsDLHsFLS..QAVFSNRTlAsFAVYTTKEKAQILYKKLM.....EKYSVTFISR..Huh..u....uHNI.....LFFLTPH.RHRVSAINNaCQKLCTFSFLICKGVNKE...	0	0	0	0
+4564	PF05010	TACC		Transforming acidic coiled-coil-containing protein (TACC)	Moxon SJ	anon	Pfam-B_4807 (release 7.6)	Family	This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) [1].  The functional homologue (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles [2].	28.80	28.80	28.90	30.30	28.50	28.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.50	0.70	-4.56	13	318	2009-12-17 14:40:01	2003-04-07 12:59:11	9	5	92	0	143	281	0	199.10	50	21.90	CHANGED	paSQKDhDAslphs+cEh..p-...........cs.-h+pKaEchppcshEMtKIlsEaEcTIsQhlE-.......................sp+p...Kplo+cplQcllpEK-Q......................shuDLNShE+SFS..................................................DLFKRaEKhKEVlEGa+K.......................................................NEEsLK....KCsp-YLsRl+KEE.................QRYQALKsHAEEKLc..................pANcEIAQVRoKApuEssALQAsLRKE.......................................QM+lpSLE+sLEQK...........................sKEh-ELTKICD-LIuKMtK	...........................................................................................h..pp.Dhsuslphh+pE..lhppE....................hEspEh..+cKYE.Ep+pEsh.EMcKIVuEYEK..TIAQ..MI...E..-..........................................................................................................cQ+p.........pphS.p...pslQpLh.hEK-Q..............................................................AhADLN.SlE+Shu..............................................................................DLF+RYE+hKpV...lEGa+K.........................................................NEEsLK......KCAp-YLuRl+.pEE..................QRYQALKhHAE...EKL-..................+ANpEIAQVRsKApsEpsALpAuLRKE.......................................Qh+V..cSLE+sLpQK...........................s+EhEELTKICDELIuKhtK.........................................................	0	36	46	81
+4565	PF02202	Tachykinin		Tachykinin family	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.50	20.50	20.90	20.50	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.38	0.74	-5.50	0.74	-3.71	12	43	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	25	3	5	60	0	10.90	62	26.56	CHANGED	pPcPspFhGLM	+P+PppFaGLM	0	0	0	3
+4566	PF04972	BON	TAD;	BON domain	Yeats C, Bateman A	anon	Yeats C	Domain	This domain is found in a family of osmotic shock protection proteins (e.g. Swiss:P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes ([1]).	23.60	6.70	23.70	6.70	23.50	6.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.71	0.72	-4.22	187	8163	2009-09-11 21:46:55	2003-04-07 12:59:11	12	45	1945	6	2280	5479	2633	61.90	25	43.04	CHANGED	psplpstLttp.....tlsst.s.lpVpsp.sGtVhLpGpVs.stpptptAtplApslpG.VppVh.stlplts	...............................tplpstLhtpt......lpsp..p..lpV..psp..sG..tVhLsGpV...optptpp.Atpl.A..p.s..l.sG...Vp..p..Vt.splph..t......................	0	572	1203	1719
+4567	PF02969	TAF		TATA box binding protein associated factor (TAF)	Griffiths-Jones SR	anon	Structural domain	Domain	TAF proteins adopt a histone-like fold.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.83	0.72	-4.03	10	386	2012-10-10 12:36:46	2003-04-07 12:59:11	12	9	260	1	262	923	23	63.60	41	12.60	CHANGED	sollPpEShKVlAESlGIusLs-EsuphLA.DVpYRl+EIsQ-AlKFM+HuKRp+LTssDlDpA..LR	........................................hhst-ol+slAESlGl..s.s.Ls--ss.ph..LApDVpYRl+clh..p-AlKFM+HuKR....p....p.....LTspDlspAL+....................	0	93	143	209
+4568	PF04658	TAFII55_N		TAFII55 protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4395 (release 7.5)	Family	The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex.   TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown.  The conserved region is situated towards the N-terminus of the protein [1].  	25.00	25.00	30.10	27.40	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.18	0.71	-4.74	35	402	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	286	0	275	378	1	157.60	35	40.36	CHANGED	lEpQhILRh.P......pss-hl+pulpssshs...........slsh+....p-tR+AsVplssphau..ApLVDLPsIlEuhKThD+.KshaKoADIsQMLlshp................lps-p.shpht.........................................ph.tp.tpcpapa...HGlTPPh+slR+RRFR.+chsc...............pthpplEccVccLLct.............DpcAp......s	......................................................lEpQFILRhss...................p.sphl+phlppsphs.p.................hslphc.........tDsR+uhlpls..s..........t...hs..ApLVDLPsllEuh.K.ThD+.KshaKoADIsQ....MLlstts......................cp.shp.s..................................................tp.htpcpa.as...HGlTPPh+slRKR.RFR.Kphpp........................hph.clE....c-VccLLptDtpA..s................................................	0	89	145	216
+4569	PF05069	Phage_tail_S	tail_comp_S; 	Phage virion morphogenesis family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Protein S of phage P2 is thought to be involved in tail completion and stable head joining.	24.30	24.30	24.50	24.40	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.09	0.71	-4.44	46	1328	2012-10-01 19:49:39	2003-04-07 12:59:11	8	5	800	0	174	1065	22	130.20	23	91.49	CHANGED	s-hptlpphLstLhtp...sss+ptlh+pluppL+cupppRhptQpsP.DGssatshp.......htt+ps+h+ct..hhpph....phuchlpspsssssss....hGssphhAtlHQaGh....................+s.....t.....plp...............hPsRshL......GloppDcphItchlhpaLs	.............................................h...tthpphhptlhtt......tthpt..hhpplup.p.lcp.s.p.ppph.pt...pp.s.P.cG..p..satshp.....................h.+..t..p.....t.t..........p..h...pp....t.....h.............htch............ph.tp..lp..h.p.s....ss.s..ts............G...p.s....t.....h..Atl....HpaGh....................................................................pt...............hp........................................................................hstR.hL.........Ghs.tt.s.......p.l.phl.....h............................................................................................................	0	44	110	145
+4570	PF02203	TarH		Tar ligand binding domain homologue	SMART	anon	Alignment kindly provided by SMART	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.68	0.71	-4.42	88	3556	2012-10-02 01:04:29	2003-04-07 12:59:11	10	31	949	15	528	4206	102	164.70	20	30.56	CHANGED	hhp+lsIpspLhhlluhlslLhlssusLuhhuhppuspslpphhpsphtppttlspu...hhpsRhsLsR...hhhhsts...t.....sphlspA.cptlspuppsaptahshsp..ss.t-pp.hssplpppapp.hppulpshhshlpuu.shsthhphsspphpshapshtpshtp....pssps	........................hppl..+lhstLhh...lLuhh.sl..L....l..s.o..uul.shhu...lp...p...s...p...p...sh......sh.pp.....t.p.p...p.s.t..Lsp.s...h...s..........h..h....p....s.R..h...s..Ls+s...............hthhh.sp.....t........................tphlss....A....p....pp....L.p....p...u....p.p.t...a....p....p....a....t........s....hsh.......ts....tst...s...hsp...plpp...p....ap.t....h...ps...ulpt....h....h..p..h.hps....u...p....hs...s..a..hs...t.s..s..p...t..hp..shhpthhtsh.t............h..............................................................................................................................	0	59	179	344
+4571	PF00539	Tat		Transactivating regulatory protein (Tat)	Bateman A	anon	SCOP	Family	The retroviral Tat protein binds to the Tar RNA [4].  This activates  transcriptional initiation and elongation from the LTR promoter. Binding is mediated by an arginine rich region.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.89	0.72	-4.35	83	7178	2009-09-12 06:54:57	2003-04-07 12:59:11	13	3	90	16	0	5391	0	64.90	66	73.19	CHANGED	M.....-slDPplEPWp+PGSQPpTsC.NpCYCK+CCaHCQ.....lCFlpKGLGISYGRKKRt.R.R+sspsspsH	.................M......EPVDP..pLEPWpH..PGSQ.PcTAC.ssCYCKKCCaHCQ.....VCFlpKGLGISYGRKKRR..QRRRs.Pp.supsH...............................	0	0	0	0
+4572	PF01026	TatD_DNase	UPF0006;	TatD related DNase	Bateman A	anon	Pfam-B_1370 (release 3.0)	Family	This family of proteins are related to a large superfamily of metalloenzymes [1].  TatD,  a member of this family has been shown experimentally to be a DNase enzyme.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.93	0.70	-5.18	98	8430	2012-10-03 00:45:34	2003-04-07 12:59:11	16	26	4852	19	2301	6563	3019	252.30	29	93.02	CHANGED	lDsHsHLsh..th.................tp............hsphl.pc.....sppsslptl.l............................ssussh................t.php..pshplucp..ast.lasslGlHP...tpsp....................................tpchh..........ppl..pph...h.pcscllAIGEhGL.....Da..............hps.sst...........ctQpc.lFcpplplAcch.shPlllHsRc......Apc.........-hlcll........................cp.t.hsth...tslhHs............................................aoGshchspphl.ch.....GhalSluuhlsa.p..upp.....hpcll..pplPh-+lLlETDuPalsP.................................sh+........G.ppNcPshlhpssctlAc.l+s.............hsh--ltphsppNspclF.s	..........................................................................................................................................hDoHsHLs.....ta....................t.t.-................................hspll....tc...A.t.p.s.GV...p....t..h..l.....................................................s..s.u.ssh......................................................p..shp......psh.p.L.upp...............as..t..........l.....a..s.sl.G.l.....H.....P..........hp.spp............................................................................................h..pptsh............ptl..pph...........t....pps.....c....l..V..A..lGE..h...GL.Da....................hhpt.sst..............................................phQpc....sF..ppQl.....p..l.....A.....p.c......h.....s.......h....P.....ll..lHsRc........................App..............................................-.h.h.plL...........................................................................................cctt...stt..............sGlh.H..s...............................................F..oG..s....h.c.h...A.pphl..ch..................................Gha..lu..hu..G...h..lT..acp......upc.................................l+-sh.........ptl.P..l..-.....+l...LlET....D.u....PaLsP..........................................................................................hPh+......................G...cpNcPsh.....l.ht....l.s...chl....Ap..l+s......................h.s....h.-...cluph.oppNstplFt.....................................................................................................................................................................................	0	745	1397	1904
+4573	PF03430	TATR		Trans-activating transcriptional regulator 	Finn RD	anon	Pfam-B_4420 (release 6.6)	Family	This family of trans-activating transcriptional regulator (TATR), also known as intermediate early protein 1, are common to the  Nucleopolyhedroviruses.   	20.40	20.40	25.10	22.50	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.95	0.70	-5.88	5	60	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	43	0	1	63	0	525.40	31	92.51	CHANGED	pMpslppS...YsusSTPs+ssFspu.pE.sshp.p...ph.phsT-hsschshssh-suh.cos.ss...shos.u.hps.hcpscp.spAssp-ascEpstpshsEtsouhosp........t.hsEohscottsssspR+uS..............ElDSDsDsu-SScG...cKhssKPKhRp+YKKuTIQsssoLoccppasTpICTVAssspIs+YFtpD......................................FusaLpch+o-sshsuNRFSDYISETGYYMFVVKKuEc...KPFE..VlFAKaVsNlspEYTNNYYMVDNRVFVVSlN+lRFMISYKLV+EpGI-IPPSpslCsDApAER.....sshKCYFs-VKc.sFpssLINaFNLDMaYuQTTFVTLMQSlGEsKosMLLNKLYcMaQD+oLFTLPIMLSRKEPslE-s...........spsssasSsYVuQIlKYSKsVpFPpssPsptVhDcL..................slIVTQKSoLTYKYSSVANLLFscYt.p....pDNNA-uLKKVKKE.DGsttLVEQYLotNpN.DcTSHNFIVLsFK..NDERLTIAKKGhEFaWIoGEIKDIsVsDLIcKYs.RasHHVF+IsNVNRRESTThHNNLLKLLuLlLQNLlcL-DlpcaAspshsCpYc	.................................................................................................................................................................................................t.........t...........t..t......tp.h....h..stp...p..p.............sps......t.pt.tppso..................................................................c.spp..csspusp......pp.h.+s...Kh...c....phcKtthps.p.tphp.....pp.p.s.p..l.sp.lts.......tph...s..p..hh.c...........................................................htshhtph.....s...spt............pspR.Fssah.psuYYMFlVp.cscs.....c.sFc.........lhasphVpsVs.EYsspYhhlDphVhVVohs+hRFMISYpLlpchtIcIP.ppphspc...thtpp.....ss.p..CaFp-VKs.tFhshLhshFpLDhhYsQsphshLhpSlGEpKsthlhpplhpMhpD+sLFTLPl.loRKEs..pps................................sp..sSsYVppIlchScs...lpF.p....s....s.....sph..hhsp......l...................................s...hhp..pp.s.hTYKYuSVAplLasp.............ppps.sspLhKlKKE.sGshtLlEpYLststs.s.puaNFIllshK.....sDERlTIlKps.-FhWIsu.I.KD...I.ssDlIpKYp.pasHHlFslspsNR+E.sshHNshlKLLuhhhpsllsls-hhphAppphsCpa...............	1	1	1	1
+4574	PF02668	TauD		Taurine catabolism dioxygenase TauD, TfdA family	Bashton M, Bateman A, Mifsud W	anon	COG2175	Family	This family consists of taurine catabolism dioxygenases of the TauD, TfdA family.  TauD from E. coli Swiss:P37610 is a alpha-ketoglutarate-dependent taurine dioxygenase [1].  This enzyme catalyses the oxygenolytic release of sulfite from taurine [1].  TfdA from Burkholderia sp. Swiss:Q45423 is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase [2].\	      TfdA from Alcaligenes eutrophus JMP134 Swiss:P10088 is a 2,4-dichlorophenoxyacetate monooxygenase [3]. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1 [4].	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-12.03	0.70	-4.72	123	5659	2012-10-10 13:59:34	2003-04-07 12:59:11	11	59	1664	78	2098	5388	5861	240.80	19	77.33	CHANGED	ph..psls.......................hs.t.........................phtpltptl.tppGlllh+...shs.......h.......sspph.ht..................hupth..G....l....h........................................................tt........pssshhsts........................hsaHsD...s.ah........tssth....thLhsh..psss...............pG...Gp..Thhss..shtsappLs.........sphhptl..p.slphhpshttthh.....................................................ttpP.....l..lphc.............s..sucpshasss.........h......th........................................thscups.....hh.....ctlhp..hh.p.....ps..chphpapap.t.....GDlllaDNtpshHuRs.sa........................stpRplh+sh	........................................................................................................................t...................................................httl.hth..l....ph.....thl.hh+.......s.................h.........s.tt.....t..........................hspth........G...............h...............................................................................................................p.t....t..................................................h.HsDhs...a.................tssth...........thltsh..phst.....................................tG.......Gp.......T.h.a...s..s..hhtAa..ct..Ls..........sthp.phl.........p....slps.h+.s.httsht...............t......................................................................t....hhpP.....l......Vc.pH.............................P....o....G....c..p..s....l..ahst.......hspph...........sh.........................................................................s..s.-.u.pt......ll...............p.Lhp....th..p........ps.......chth.p.a.c.Wp..s....................GD...l.....hhhD.......N.t..ts.Hht...s..........................t..Rhhhth...................................................................	0	584	1221	1766
+4575	PF01361	Tautomerase		Tautomerase enzyme	Finn RD	anon	Prosite	Domain	This family includes the enzyme 4-oxalocrotonate tautomerase Swiss:Q01468 that catalyses the ketonisation of 2-hydroxymuconate to 2-oxo-3-hexenedioate.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.42	0.72	-4.36	28	2760	2012-10-01 20:38:22	2003-04-07 12:59:11	16	3	2116	139	636	2083	293	59.20	29	84.64	CHANGED	Phlplclh...cGp....osEQKcpLlcclT-shscshGt.spssltVllcEhspssauluGcshspt	.....................Phlplclh........cGc........opEQ.KppLspclT-s..lsc.....s....h.ss...s.....p.p....s..l.p....VlIpEhppssauhuGp.h...t.........................	0	159	365	504
+4576	PF02959	Tax	HTLV_tat;	HTLV Tax	Bateman A, Jeang K	anon	Pfam-B_1456 (release 6.4)	Family	Human T-cell leukaemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukaemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-kappaB [1].	20.60	20.60	22.60	22.20	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.57	0.70	-4.89	4	661	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	18	5	0	385	0	177.20	81	65.43	CHANGED	HFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQlTWDPIDGRVlu.....................................................phEPTLGp+LPoLuFP-PGLRPQNlYThWGtoVVChYLaQLSPPlTWPLlPHVIFCHPtQLGAFLTpVPhKRlEELLYKluLTTGslIlLPEDsLPTThFQPuRAP	...............................................SLLaGYPVYVFGDCVQGD.WCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQaLIPRLPSFPTQRTSKTLKVLTPPhTHTTPNIPPSFLQAMRK.Y.SPFRN...GYMEPTLGQHLPTLSFPDPGLRPQNLYTlWGuSVVChYLYQLSPPlTWPLlPHVIFCHPtQLGAFLTNVPhKRlEELLYKIuLTTGAlIILPEDCLPTTLFQPsRAP..............................................................................................	0	0	0	0
+4577	PF00683	TB	TGF-bp; 	TB domain	Bateman A	anon	Pfam-B_82 (release 2.1)	Family	This domain is also known as the 8 cysteine domain. This family includes the hybrid domains [1]. This cysteine rich repeat is found in TGF binding protein and fibrillin.	20.90	20.90	21.00	21.00	18.70	20.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.77	0.72	-4.39	34	2359	2009-01-15 18:05:59	2003-04-07 12:59:11	12	321	62	9	1128	1987	2	42.80	35	12.21	CHANGED	spCptslsst..sTKsp.CCCshGt....AWGss.CE..hCPhps.ospappl	...........tC.s.tsl.sst..sTKpp.CCC..o..h.Gp.........uW...G....ss...C..E....hCPhts..ospaptl...............	1	138	208	540
+4578	PF00566	RabGAP-TBC	TBC;	Rab-GTPase-TBC domain	SMART	anon	Alignment kindly provided by SMART	Family	Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.90	0.70	-4.86	101	7104	2009-01-15 18:05:59	2003-04-07 12:59:11	13	151	344	13	4605	6792	78	197.50	19	30.10	CHANGED	pphRtpl......W.hlhs.................................t....t..pttt.t....ppIc.hDltRThs...................ppt.ttpp.pLpplLpuauhhss...p.lG.......Ys..QGhshlsuhlL.......................hhh.s-pp....................uFhshsplh............thhhpshatpsh......t..lpthhh...hhcpllp.phhPc...lhp+.l.pc........slp..h.ashpW....hlsl.Fs.pshsh.phshR....lWD.hhh....pu......ph.lhp.hslu.ll.phh...cp.pll	.....................................................................................................................................................................................................hR..hW..h.t......................................................................................................................................................p.......pt........I...p....hDl....R.oh...............................p.........h.ttt...t.ptL.....h.......p..l.......L....h.......s....a..u.h....h...ps..............p..lG.............................................Y...s....Q........G..........h..s.............lsuslL.....................................................................................hhh....sEtp........................................uFhhhs.tlh..................hhhp..s..ha.p.s.h.............................s...........hptpht................hhp.p.l..l..p...ph.........Pp.....Lhp+..l...pp......................................h.sl..p....t..h....a.s.hpW.............hh.sl.F..........t..p.........p...........h..s.......h....p.............sh+................lWD.hhh.....pu...................................ph..lhh....lslu..ll...h.pt........................................................................................	1	1678	2429	3584
+4579	PF02970	TBCA		Tubulin binding cofactor A	Griffiths-Jones SR	anon	Structural domain	Domain	\N	23.20	23.20	23.40	23.20	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.78	0.72	-3.91	38	366	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	285	4	243	354	0	91.30	34	79.30	CHANGED	QLcIKsusl+RLlKEcthYccElppQpp+lc+h+sc....st.-cYslKpQ..cpVLpEoptMlPchpp+lppshpcLpph..lpstct.....hc-hsptp......cA	..............pLcIKTusl+RLhKEcthYc+EhcpQcp+l.......c+h+s-...........ss.-pY....slKpQ..........pclLpEochMlPcspcRlptAhtcLpph...Lpptpp......hc-hpphh................................	0	76	124	191
+4580	PF03558	TBSV_P22		TBSV core protein P21/P22	Finn RD	anon	Pfam-B_3028 (release 7.0)	Family	This protein is required for cell-to-cell movement in plants. Furthermore, the membrane-associated protein is dispensable for both replication and transcription [1].	20.60	20.60	20.60	24.80	17.30	20.50	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.14	0.71	-4.88	2	32	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	24	0	0	31	0	185.20	71	95.35	CHANGED	MDsEYEQVs+PWNELYKEATLGNKLsVNVG.EDsElPLLPSNaLsKsRluhSGGYIThRhlRI+IlPLVSRpuGVSG+LaLRDIoDTTG+KLHsTELLDLGKEIRLohpHLDFSVSsRSsVPIVFGFE-LVSPaLEGRELFSVshRWQhGLSAQsYSLP.s.WKVhYQE-sL+thhP..KKAsKTsSs.	.............MDTEYEQVNKPWNELYKEsTLGNKLhVNVGMEDtEVPLLPSNFLTKVRVuLSGGYIThRRlRIKIIPLVSRKAGVSGKLYLRDISDTT.GRKLHCTEpLDLG+EIRLTMQHLDFSVSsRSDVPIVFGFEELVSPFLEGRELFSlSlRWQFGLSpsCYSLPpuKWKVMYQEDALKsLKPSK.KKASKTDSS.V...................................	1	0	0	0
+4581	PF01840	TCL1_MTCP1		TCL1/MTCP1 family	Bateman A	anon	[1] & Pfam-B_7391 (Release 8.0)	Family	Two related oncogenes, TCL-1 Swiss:P56279 and MTCP-1 Swiss:P56278, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [1]. This family contains two repeated motifs that form a single globular domain [1].	25.00	25.00	43.40	40.90	16.80	14.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.81	0.71	-4.61	8	104	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	31	6	50	77	0	104.10	40	95.40	CHANGED	MA.ssshpsphPhPPshLhshccsIYEDEapRsWlslsVEoocp.......s.ss+hcsplTVHLpphsslhpEshsss.lssspLPtMWpL.scspYpusDuoaWRLlcHuQhsssEpLlLcLlss	.........................t.phss.Ps+LWlhptslY.DEhpRo.Wlslshc.ssthp.................................V+lpQhpV.hG-.shpPoplssS.LPlMWQLY.Ptc+YpusDSphWcIhaHlp..l.pusp-hlLchlsc........	0	3	3	8
+4582	PF03634	TCP		TCP family transcription factor	Bateman A	anon	Pfam-B_1979 (release 7.0)	Family	This is a family of TCP plant transcription factors.  TCP proteins were named after the first characterised members (TB1, CYC and PCFs) and they are involved in multiple developmental control pathways [1][2][3].  This region contains a DNA binding basic-Helix-Loop-Helix (bHLP) structure [1][3].	19.90	17.00	20.20	20.20	19.60	16.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.60	0.71	-3.80	113	2128	2009-09-15 15:36:31	2003-04-07 12:59:11	8	3	670	0	282	2132	1	128.50	28	54.94	CHANGED	sss+KDRHSKlpTutGsRDRRlRLSltsAt+hFsLQ-hLGaDpsScTl-WLlppucsAIpclsss................................sssss.............s..........t.....t....................................................tt.ttth.t.ttspppss..hshsc...ps+....................scuRs+.....u+c.coppchphptthss	.........................................ppch.Tt.s.RsRR...hRLshthAtpFFsLQ-hLGaD+sS+Tl-WLlspSKsAIc-Lspp.........................................................p.sss..............s.s..................p...t.p..........................................................................................p...t............t..................p.....tp...............................t..........................tt...................................................................................................................................................................................................................................................	0	30	170	231
+4583	PF03645	Tctex-1		Tctex-1 family	Bateman A	anon	Pfam-B_2986 (release 7.0)	Family	Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction. 	20.50	20.50	21.00	20.70	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-4.18	104	888	2009-01-15 18:05:59	2003-04-07 12:59:11	8	19	260	9	593	840	7	100.80	26	53.99	CHANGED	ss.......clppllp.cslpptLts.t.......pY.pt.scspphsppls-plhppl.pp......h.................ppYKalVpshIhp.............................................ppspGl+suopshWDs.....ssDshsohpa..........pNcslaslssVaulhh	.....................................s.tlppllcpslpptLts.t.......tY....pt..pp...s....sphsppls......-plhppl.pch.............................................ctYKal.......V..pss.Ihp.........................................................ps.u.t.G.lcsu....opshW.....Ds.....ps..Dshsohpa..........cNpo..h..aslssVaulh...........................................	0	246	318	461
+4584	PF00838	TCTP		Translationally controlled tumour protein	Bateman A	anon	Pfam-B_1548 (release 2.1)	Domain	\N	20.80	20.80	21.20	21.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.05	0.71	-4.25	9	650	2012-10-01 21:11:27	2003-04-07 12:59:11	12	9	399	15	320	645	3	149.40	39	92.31	CHANGED	MllYKDlhosDELhSDSash.cllssllaEs-G+hVspp..us-ph.IGANPSAEGu-....EGs--sscpslDlVhsaRLpEp..uFDKKsahsYlKsYMKslps+Lpcpp.Ec..l.hFcKplpsalKplLup..FK-hpFFlGESMss...DG.VslhpYR..EsGtsPahhaaKcGLhE	..........................................MllYpDll..o..s...DEhhSDs.a......ph......c......l.h.s......s..l.......h...a.EV.cu+h..lsp...............sss.s..lG.uNs....SAEts-..............EG...s..-.....s.s..s....pslDlVhs...a..+L.........p.........Eo.........sF.s.....Kcsahs.....Y..l.K.......sYhKplps+.....L...c-...p....p..s..-p......................lp.FppsstthhK.c.l..Lup...a..Ks..hp.F..............ah..G....Eo..Mss......................DGhl...shhpY+........-su...ssPhh.haaKcGLp..........................	1	93	147	215
+4585	PF03347	TDH		Vibrio thermostable direct hemolysin	Mifsud W	anon	Pfam-B_3633 (release 6.5)	Family	\N	20.90	20.90	20.90	49.20	20.80	18.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.99	0.71	-4.70	2	84	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	15	1	2	77	0	138.50	78	90.33	CHANGED	h-LPSIPFPSPGSDElLFVVRsTThpTcpPVpshVpDaWTNRslKRKPYcDVYGQSVFTTuGSKWLouYMTVsINs+sYTMAAlSGYKcGhSoVFsKStphpL.QcaY.SVtsFVsssEpSIPShsYLDETPpYFVsVEAYESGsGphhVMCISNK.SahECcpQ.	.h-LPSl...PFPuPGSDElLFVVRsTThpTpuPVNshVsDaWTNRNlKRKPYKDVYGQSVFTTSGoKWLouYMTVNINs+sYTMAAlSGYKcGpSsVFsKS-pspL.Qc.Y.SVusFVGEs.EpSIPShhYLDETPEYFVsVEAYESGsGphhlM...........................	0	0	0	2
+4586	PF01285	TEA		TEA/ATTS domain family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	21.30	22.40	18.50	19.80	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.82	0.70	-5.32	19	717	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	216	11	331	600	0	283.20	40	76.13	CHANGED	sP........ssh.......................hpstuss..sssc.pspu.h+s.c...................pDuEsVWSs-lEpuFQpALth.PPhGRRK..hS-cGK.YGRNELIAcYIhh+TGKpRTRKQVS.................................................SHlQVL........pShLK........tD.shpphsp.psAphssups..............................sstPphpss.lcshspstYs.h.sss.sshht......hpPhs..hssP...............ssshp..shsosplphlpFshalpt.p.psDphs+..HLas+lptsp.p.ssPslch.-l+phhspFPchpuuLc-.................Lh-chP.ssuhhhl+h.hDl.sssh..t-s.........ssuhYhhs........spYEotcNhshs....sSTKV...............ho.sKQVsEKspp...caAthEpsRhhaR.phSshpEhhhsh.ppL++Lsc+YhhNSs......................ltshThhpVlos.......pso.cs.........Lsl..........s.Vacs.ssppHGs.H	..............................................................................................t...............................................................t.........................................t..p..shWs..clEpuF.puLthh....GppK..................hp.pu..+..a.G.RNELIucY............I...h......h+........T.........G....K............p......RTRK...QVS....................................SHIQVL..........................+p...h...pst.l.K...................................p......h...t...h.......t........t.................................................................................................s.....h.p........p...........as...........s.............s.......................................t.s.tth..hthp.............hhp..t............h...............h..h...................h........h................htp..............................t.hh..th..h.ph.............................t..a...........p.hpu..cph...h...ssohs...................ho.s+phscphp................................t..tt+..a....o..............................................................................................................................................................................................................................................................................................................................................................................	0	80	133	231
+4587	PF03848	TehB		Tellurite resistance protein TehB	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.07	0.71	-5.13	6	1247	2012-10-10 17:06:42	2003-04-07 12:59:11	9	8	1191	16	158	6802	2835	180.30	47	77.23	CHANGED	FaC+cEDYFpKKYNhTsTHSEVlEAVcsVpPsKsLDLGCGQGRNSLaLuLhGYDVTAhD+NssSIu.Lpcht-+EsLs.lpsulYDINuAslsEpYDFIlSTVVhMFLpscRIPpIIpNMQc+TpsGGYNLIVuAMsTsDhPCslPFSFTF+EsEL+cYYpcWEllKYNEshGpLH+TDtpGNRIKh+FuTML	................................................hhhcsEsY.F.sc.KY...t...h...s..........s..H...S........-.....V.......l......p.......A......h........p..........s......V.......p........s.......G...K.......s....L.DLGC...G.p.G...R....N.....S....L..a...L...A.........t....p........G....a...D.....V...T...A..h..D.....pN.s......h..u...l.......t....p.......l..p.........p.......I...t...p..........t............E.........s......L....-............l......p.......s......t.....l.....h.......D....l....N.....s.......h......o....h..........s.......t......p.....Y.....D....F.....I...l...S....T..V....V.....h....M....F...L.....p.......s.......c....p.......I.....P.......u...l......I...t.N.M.Q.c...p....Tp.s..G....G....Y....N....L...I.....V..s.......A........M..........D.......T...t..........D..a.........P..........C..........s...........l....s........F....P......F...s..F...K.E..........G...E....L..........t..c.Y...Y..c..s..W...E...h...l.K.Y..N..Ess.Gc...LH.+.pDtNGNRIpLRFAThL.............................................................................................................................	0	43	94	129
+4588	PF02765	POT1	Telo_bind;	Telomeric single stranded DNA binding POT1/CDC13	Mian N, Bateman A, Griffiths-Jones SR, Sammut SJ, Wood V, Mistry J	anon	pdb_1s40	Domain	This domain binds single stranded telomeric DNA and adopts an OB fold [1].  It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping [2-4].  POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [5,6].	21.10	21.10	21.40	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.93	0.71	-4.28	48	329	2012-10-03 20:18:03	2003-04-07 12:59:11	12	6	201	64	177	352	3	138.30	21	19.57	CHANGED	assls....t.hppsthhshhullhssphs..hps.pt..scahhshpl.....hD.sh.s.t.............stlplhhappphppL........................P.lpp.GDlltlc........................................................php..............lptasschp.........usssst..................ssatlF...psshsssh.................shhtusp...aphssp-pph...lpsLhphtt	.........................h........p.sphlslhuVVhphp.s...hho.+G....sDaptslpl.....sDpoh......................sslps.plFpssh.ctL........................Ptlpp.GD.llhl+...................................................................pl+....................................lphapscht.........slssps.......................uhhhF...........tst.ss.sh....................tsst..hphstp-pphhttLh.h..t.........................................................................................	0	42	85	131
+4591	PF03070	TENA_THI-4		TENA/THI-4/PQQC family	Mifsud W	anon	Pfam-B_2039 (release 6.4) & Pfam-B_7791 (release 7.7)	Family	Members of this family are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase [1].  The THI-4 protein, which is involved in thiamine biosynthesis, is also a member of this family. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4 [2]. This family includes bacterial coenzyme PQQ synthesis protein C or PQQC proteins.  Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria [3]. PQQC has been found to be required in the synthesis of PQQ but its function is unclear.  The exact molecular function of members of this family is uncertain.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.19	0.70	-4.58	25	3227	2012-10-02 21:56:19	2003-04-07 12:59:11	11	23	2223	70	822	2427	629	201.20	20	78.91	CHANGED	cpplc.hhpphhp..HPFhttltcGsLs+pphptalhpcYhYltshs+hhu...hhhu+ssDhphhhchhpphh-thssE.....lpha.h+hs-tlGlshp-..lppppssPuscsalshhlsh.uppsshtEshsAhhsphhuhtphs..............................pphpphlp........tt..ahcalssassp.acptlpctpchlcplhphhtspt...........hpchpplhhpshpaEhsFh.stshcs	.......................................................t....p.hhpth.hp.......H.sFlppltpGsL..s..tpth..phYlhQDh.hYl.t.pasp.h.hu......hhhs.........+.....s.....s.........s....h....c...t.....h..t..h..........h...h.p...p...h..........t.s...h...htsE......................hph.a...pphh.....p.tl...G..l.s.....t...p-............hpp.t.............hs..Pss.........htYssa.hh........ph...s.........tp......s..s........h..t....p..h..h.u....uh.l.s..s.....hhYt.phu..................................pp.l...t..p.p.p.........................t..a.tpWIp.h.au...s..c......a...p...p...hl.p.........th..hp...h.......lsp.h.h.pt..h.sppt........................hpchpphahpusphEhtFa.phuhp.h...........................................................................................	0	226	474	673
+4592	PF04876	Tenui_NCP		Tenuivirus major non-capsid protein	Kerrison ND	anon	Pfam-B_6119 (release 7.6)	Family	This protein of unknown function accumulates in large amounts in tenuivirus infected cells.  It is found in all forms of the inclusion bodies that are formed after infection [1].	21.00	21.00	21.10	277.70	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.09	0.71	-4.72	4	65	2009-09-11 07:41:10	2003-04-07 12:59:11	7	1	9	0	0	61	0	173.80	81	97.70	CHANGED	spppsDVuVGPIsGLNYphLYDhLPspVSDNITL.DLK-P-+VTEssKKLILKGsl.lAYHHPLETDshFspVHKHhP-as+SFLEHLLGupspspNuhIDlGhFFslLQspLGDWITcpaLKHsN+MSKpQIKpLlspIIchAKAEuuDTEpYEcVWKKMPuYapsllp.lLHK	.V.QRTIEVSVGPIVGLDYTLLYDTLPETVSDNITLPDLKDPERVTEDTKKLILKGCVYIAYHHPLETDTLFIKVHKHIPEFCHSFLSHLLGGEDD.DNALIDIGLFFNhLQPSLGGWITKNFLRHPNRMSKDQIKhLLDQIIKMAKAESSDTEEYEKVWKKMPTYFESIIQPLLHK.	1	0	0	0
+4593	PF03300	Tenui_NS4		Tenuivirus non-structural protein NS4	Mifsud W	anon	Pfam-B_4315 (release 6.5)	Family	\N	20.60	20.60	21.00	406.10	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.66	0.70	-5.33	5	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	9	0	0	53	0	284.70	82	98.63	CHANGED	MSLu+lsSpSKSplLsDDLSE+uAK+h-cuNKKKLALSsRPL.............TKGRhTIDsAATVLGLEPFSFADVRsNoYDMFlAKQDYSIpANR+A+FsIDV-Ph.aF+KPLppaPFFRIATFAlVWIGIKGRAsGTlTFRIIDKSYlDPsDQVEVEVsYPISKNFAVLGSLPNFLuhEDtcNLQV-lsIcDuSVQNCVISRoLWFWGIERTDLPVsMEoQKTVMFEFEPLsD+slNHLSsFuNFTTNVVQ+AVs......sAFTTKuhsElDsthEFGVVKQP+......pIPI..........l+K++Shl-	MALSRLLSTSKSKVLYDDLSEESQKRVDNKNRKSLALSKRPL.............NQGRVTIDQAATMLGLEPFSFSDVKVNKYDMFIAKQDYSVKAHRKATFNILVDPY.WFHQPLTHYPFFRVATFAMVWIGIKGRASGITTLRIIDKSYVNPSDQVEVEVRYPISKNFAVLGSLANFLALEDKHNLQVSVSVDDSSVQNCVISRTLWFWGIERTDLPVSMKTsDTVMFEFEPLEDKAINHLSSFSNFTTNVVQKAVG......GAFTSKSFPELDTEKEFGVVKQPK......KIPI..........TKKSKSEV.S	0	0	0	0
+4594	PF05099	TerB		Tellurite resistance protein TerB	Bateman A	anon	COG3793	Family	This family contains the TerB tellurite resistance proteins from a a number of bacteria.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.51	0.71	-4.45	153	3006	2012-10-03 21:00:09	2003-04-07 12:59:11	8	32	1728	5	694	2123	2633	135.10	20	59.21	CHANGED	t.lpph..htphh.sss.sphtss.t............plAlsA....LhsclApADGphspsEhptlpplltpthslsstpspplhptspptppc........ssshhpasptlpcths.........cp+hpllcsLWplAhADG....phcttE-sllcclAplLslscp-hhth.....+t	..........................................................................h.hthth...................t..t..t.............h.sshs....lhsclsp.u.D.Gp.lsps..E...h..phh...p...p......lh.......p.....p.....h....s....L...p....s.....t....p..p..p...t....h...t...p....t.h.p...t...tppp........................................shsh.p..ph....h.p....p....lcp.h...............hch..t.p....t...hLchhhpl....Ah.A.D.G........plcspEcplLpplAphLGlsptph.....h...........................................	0	189	419	574
+4595	PF03741	TerC		Integral membrane protein TerC family	Bateman A	anon	COG0861	Family	This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance [2]. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.07	0.71	-4.84	93	6495	2012-10-03 02:02:08	2003-04-07 12:59:11	11	11	3058	0	1376	4775	2679	192.90	30	58.96	CHANGED	hslhhlEhsLSsDNhhVlullspp...lPtp.......................pc..+slhaGlhuAllhRhlhlhhushLlph.................................shlhhluGhaLlahuhchlht.h.................t.hpphhshsssh........................................hhhsllhIthsDllFulDSlhAshulo................pchhllhsuslhuIlslthhuthlsphlc+ashlphsshslLsalGsch...llps	......................................................TlhllEhlLulDNllhlullssp...LP.s.p......................p.pc.+.A.hh..h..G.l.h.h.A.l.l.h.Rhl....h..lhh.h.u.allsl.....................................................................h......sh..lhhlG.Gl.....F..Ll..apusp.lpcph.................................c.tt..c..pt.h.tt..ss.st..........................................................................................................hhhslhpIh.....lh..DllFu..l.......DS...l...lsshGhs.....................schhlh.h..s..us.ll.Alh..lhhh...s..uphl..s......p..h..lp.+..a..P..t.lth..hshshLhhIGhpLlhps..................................................................................................	1	380	808	1111
+4596	PF02342	TerD		TerD domain	Anantharaman V	anon	Anantharaman V	Domain	The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [1][2] It is found in a stress response operon with TerB and TerC.  TerD has a maximum of two calcium binding sites {2] depending on the conservation of aspartates {2]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie  at the center of membrane-linked metal recognition complexes  with regulatory ramifications encompassing phosphorylation- dependent signal transduction, RNA-dependent regulation,  biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways [2]. 	25.30	25.30	25.80	25.50	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.19	0.71	-4.96	187	3080	2012-10-09 20:46:33	2003-04-07 12:59:11	13	38	634	6	728	2301	75	182.90	29	70.99	CHANGED	hthsLsKGp...plsLscpss.......tplplsls.Wc.ttt..............................tshDLDsSshhlstt.............s+stsssphlFasphpusssul.h.......................sGDshsut....t............................................................................................sEslplsLspls...sslpcllhslolasut................Fuplpsuhl.clhst..................sspplsc......asls....shsscouhlhuclYRc.............................supW+.......hpAlGpGh......ssGlts..lsppaGhtl	.........................................................................................lsLpK.Gp...plsLsKpss......htplhluLuWcstt.tt...........................................tshDLDsSshhl..ts.....................s+st.ssschlFa..s..shp.u...s..s.....G.u..l..ht..........................................sGDshTGt.....ut.G.D............................................................................................cEplpl.cLsp.ls.....splc+llh.s.V.sIasups..............sFuplpsu.al..Rlhst..............................sspEls+......acLs....tshutcTuhl...huElYRc.................................................................supWK...FpAlGpGh.......ssGLts.lsptaGh..............................................................................................	0	203	487	654
+4597	PF03592	Terminase_2	Terminase_small; 	Terminase small subunit 	Finn RD	anon	Pfam-B_3755 (release 7.0)	Family	Packaging of double-stranded viral DNA concatemers requires interaction of the prohead with virus DNA.  This process is mediated by a phage-encoded DNA recognition and terminase protein. The terminase enzymes described so far, which are hetero-oligomers composed of a small and a large subunit, do not have a significant level of sequence homology.  The small terminase subunit is thought to form a nucleoprotein structure that helps to position the terminase large subunit at the packaging initiation site [1].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.96	0.71	-3.90	71	1427	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	1058	51	150	1030	539	147.30	23	79.63	CHANGED	LTsKQctFspEYlt.....s.hNATpAAl+A.GY.....St+o...Apshu...sc.LpcscIpphIsEt...hpchppcphhssc-lLphLsclspu-hp-.h.h..t................................................ttspthp.hpsphpD+l+Ah-h.LuK+hs........hp-c...........t.t.t.hhp..ht......s	................................LTtKQcpFsptYlp.....s....h.Ns.TpA...Al......pA..GY.....Ssco.....Ap...spuscLLc.p....s...c.......lpth.I...pch.......pp...ch....hp...c....th.......h..shppl.l..thL...tp...hths..p..pc.h...h..h...t...................................................................................................t.thh....h..p.tsc.cuhch.lh+hht....h....h.pp.............................tsst..h.................................................................................................................................................	1	40	90	117
+4598	PF03936	Terpene_synth_C		Terpene synthase family, metal binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_728 (release 3.0)	Domain	It has been suggested that this gene family be designated tps (for terpene synthase) [1].  It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.46	0.70	-5.17	87	2046	2009-09-15 09:56:15	2003-04-07 12:59:11	11	32	433	92	834	2322	3	234.00	21	48.78	CHANGED	lLclA...KLs....FNhhQthappELcpls+Wa+-hsl.scLsh.hR-RllEsYahshushaEPp..aStsRlhhsKhhhlhsllDD.....haD..sauohcE...lc....thscslcRW........s...ssh-.pLPcah+hsapslhchhp-htpchtpc.scp......hh.hhtcthpphhcuahpEucWh......pss.hhPo.h-EYhpsuhhohuhhhhhhhshhsh...sphhs.cpshchlpppsp...lhchhshhsRLh....sDltsa..........................pcEhp+GchssulpsYMcph.ssocE-Ahpclpphlppsh..+phs	..............................................................................................................................................hs...........p.....pht.t.h.......p..........p...W.........h.pp.........th.....t..p...h........h....+.....cc.....hhphhhh..h.hu.h.h.hp..Pp.....hu.tR.h.h.h.s.+.hhshhh.hh..DD............ha.D....shu..sh.c-.............hp...........hhspslp.ph..............................s........sshp..th.s.p..h...h......c..h.....h...h.....h..s..l..hs.....h...h...........p..ch.tt.phtt.p.....ttp...........................h..ht.pt..htphhp.u..hh..h.E.s..c.ah...................tps...hhPs..h...pEYh.p.t.hho.s.uh..hhhshs.hh.....hh....t..hs..cpshp..h.htp..st.............lhph...sshhh+...Lh..................sD.lhoh..........................................p.p..E.........p......c.......s.p......h..s...ss.l....h...h.h...pp......h...s.h.o.pp.Ahpthtthlppthcph...........................................................................................................................	0	148	537	713
+4599	PF02909	TetR_C	tetR_C; 	Tetracyclin repressor, C-terminal all-alpha domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.52	0.71	-4.52	18	1930	2012-10-03 00:15:22	2003-04-07 12:59:11	12	6	804	87	677	1699	15	139.70	19	61.05	CHANGED	hP.pss-.sWpshLpssA+ShRpALLsaRDGA+lahGo.tsussphcshEspLphLscsGFosccAlhslpslupFslGuV........LEcQu..tpsstpspptss.hppth.s...Pl....Lppshp...shspsss-ssFEhGLpllIsGlcsth	..........................................................st..sWcstLpshAcshRpshhpH..P...t.s......s.p...l.h..h....s...p..........s..........h....u.......s......s......t......h......p....h....h-...thl.t.hL....p....s....s......Gh.s..s.t.p.s....h.t..sht...sl..t....t....alhGts.....................................h.p....p...p....s................t.....t.s..s........t........h..t...t..t..sh.....htth......................Ph..........lt.t.sht......................ht.t.........s.........c.....t..t......F.....p....hGLphllsGlt...h..........................................................................................	0	228	518	626
+4600	PF03299	TF_AP-2		Transcription factor AP-2	Mifsud W	anon	Pfam-B_1736 (release 6.5)	Family	\N	20.30	20.30	23.70	22.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.14	0.70	-4.78	6	424	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	99	0	242	359	1	190.70	64	48.09	CHANGED	ssEVFCsVPGRLSLLSSTSKY+VTVAElQRRLSPPECLNASLLGGlLRRAKSKNGG+pLR-pLcKlGLsLPAGRRKtApVThlTuLVEuEAlHLA+DFuhVCEsEFPu+slApals+pplss.p-hstR+phLhtopplsp.EltclLopDRoPlssp+spshL..-sulQpsLoHFSLhTHGFGssAhpAslpulQshlsEulphl-Khh.	.............................................sEVFCSVPGRLSLLS.ST.SKYKVTVuEVQRRLSPPECLNASLLGGVL.R..R...AK.SKNGG..Rs..LRE...+L-KIGLNL...PA....G..R...RKAA..NV...TLLTSLVE.G...............EAlHLARDFG.YlCETEFP...uKAluEa.L.sRpHt.-.s.....s.-...tsRKsMLLA..oKQlCK.EFsD.LLuQDRo..PlG...sS..RP.sPIL.......Ess.I..QssLTHFSLITHGFGsPAlCAAloAhQNYLsEuLphhDKh..h.............................................................	1	59	75	151
+4601	PF02559	CarD_CdnL_TRCF	CarD; TF_CarD; CarD_TRCF; CarD-CdnL_RID;	CarD-like/TRCF domain	Mian N, Bateman A	anon	COGs	Family	CarD is a Myxococcus xanthus protein required for the activation of light- and starvation-inducible genes [1]. This family includes the presumed N-terminal domain, CdnL.\	     CarD interacts with the zinc-binding protein CarG to form a complex that regulates multiple processes in Myxococcus xanthus [4].  This family also includes a domain to the N-terminal side of the DEAD helicase of TRCF (transcription-repair-coupling factor) proteins. TRCF displaces RNA polymerase stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription [3]. This domain is involved in binding to the stalled RNA polymerase [3]. The family includes members otherwise referred to as CdnL, for CarD N-terminal like, whichdiffer functionally from CarD. The TRCF domain mentioned above is the RNA polymerase-interacting domain or RID [5].	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.11	0.72	-3.96	152	5749	2009-09-12 00:28:14	2003-04-07 12:59:11	11	11	4259	6	1333	4473	2560	101.50	33	11.35	CHANGED	plphGDh......VVHspHGlGpatulcphpl.......sGhp....p-..alhlpats......ss...p...lhlPlsp.lshls.Ralus..psph..hLscLusps..........W....p+ppp......Kl+psshphus-llchhu	......................LcsGDhVVH.pHGlG+ahGl...p.s.h-l.......................sGhp.........p-..YlhlpYss..........sc......pLaVPVs.p..lchlu..RYluu.............psph...sh......Lp+LGusp..............W........p+t+p..............Ksppplc-lAs-LlclY.....................................................................	0	485	917	1141
+4602	PF03529	TF_Otx		Otx1 transcription factor	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	27.10	27.10	22.30	21.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.58	0.72	-3.77	22	293	2009-09-10 18:52:32	2003-04-07 12:59:11	8	2	133	0	88	237	0	92.20	55	34.78	CHANGED	SPASIS........P...hs.DP.Lus.....uouSCM....QR..........suuYPMo.YsQu...suYu.QG...Ys.u.SoSYFuGlD.CuSYLu.PM.....HsQLsusGusLSPMuusu..Muu.Hlspus	.......................................................................................SPASlS......P........LP.-P.h.ss.......u.suSCM....QR....................ssSY.PMo.YsQu...uuYu.QG...Ys..s...SSSYFuGl.D.CuSYLu.PM........Hspht.s.........pLSPMusso.huu.Hhppp...................	0	3	11	34
+4603	PF03849	Tfb2		Transcription factor Tfb2	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.20	21.20	21.20	21.30	18.40	20.70	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.01	0.70	-5.82	24	407	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	301	0	280	375	6	296.10	32	69.68	CHANGED	-YLcuLPsplhs+LY.psPATCLAIaR.hLPslAKhalMpMla.-pPlshp-l-pWl+ssu.....ptppppulcpLppL+lh...........................spssst...thlpLNssF+ps.h+pALsGGtppsSFGsssspss.....pcssslshLDpYAtp+WEslLHaMVGostspt..........sSp..sVhpLLpputLhct.....sssthc......ITspGFQFLLQDsNuQlWsLLLpYLchuE........shsMDsV-lLsFLFhL......uuL-LG+uYshss.Lo-TQhphLpDL+DaGLVaQ+ps..psppFY.PTRLATsLTSsssshpssstu.pt...................................pspshppGhlIlETNaRlYAYTsSPLQIAlLuLFsclchRFsNhVsGpITRESlRpALtsGITA-QIIsaLpsHAHP	...............................................................................................................altt.hs.thhppLY.....tp.s..............hshulaR.................LP.l...A+.hlh......thl...a....h....p.p.s....ls...........tslt.........W..........s......t.p........................tpt..ppuhphLtt.L+lh...............................................t........tt......th.lss.Fp..ps.h.........p.s......LhG......u.....sp.....t......s...........................................tt..hs..ht.L-pYu.ppWEs.......lLtahVss....st.t..................u.t..shhplL..tutLhpt..........tt...t.t.........................ITp.tGF.....pFLL.-hssQlWhhhl.Ylp..h.p.................................tht.hs...s.-hLsF..lF.L....................u...pl....G............p....sYphps......h.op...s..h.........p......h.....LtcLt-hGLla...p..p..t........pt....thaa...PT...+L.A......h.........sLsss.s..s........................................................................................................................tttppGhlllETNa+lYAY...........Ts.....S.......Lp.....l.ullsLFsch.h..RhP.N..........hlsu.tlTRcSlppAlttGIT.ApQIIpaLpppAHP...............................	0	104	161	236
+4604	PF03153	TFIIA		Transcription factor IIA, alpha/beta subunit	Mifsud W	anon	Pfam-B_3542 (release 6.5)	Family	Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in Pfam:PF02268 and Pfam:PF02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step [1]. After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription.	30.50	30.50	30.70	30.70	30.20	30.20	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.47	0.70	-4.56	31	563	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	271	8	357	547	0	253.50	22	80.52	CHANGED	+lYcsVI.-DVIsssRpsFt-p.GlDEQsLp-L+plWppKLspopsschsa-sss..sss..stp........................................t...........ss.pp.psps.sssssstshthssG...............thtstsG..hpsthPshss..ss.st.......t...............htthptshstsuuspss...........t........................................................tt.shtp.sss.ht...................................ppscustss.............t...sp.hpstt...........................hc.phhshputth..slpptspt..ttpp....................................................................................................................................hQhDGssssssp............pcp....D.-D-.......................................lppD..sssDDhs.cpDsp-..ssssVhlCpYDK...........VpRsKNKWKhpLKDGIhshsGKDYVFpKApGEuEW	...........................................................................................................................................................a..lh.tpVh.t.....p......F.p......s...t.thl.php.t.W....ptKh...t.ts..h..p...t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..s...................................p.pp.................................................................................pp-..s...D-......pc.....p...t..............tplhlC.aDK...........lpR......s+s+......WKh.LKDGlhphss+.-hhFt+s.s-h-a........................................................................................................................................	0	117	189	283
+4605	PF02268	TFIIA_gamma_N	TFIIA_gamma; 	Transcription initiation factor IIA, gamma subunit, helical domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4941 (release 5.2)	Domain	Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The N-terminal domain of the gamma subunit is a 4 helix bundle.	20.90	20.90	22.50	21.70	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.31	0.72	-4.38	21	360	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	275	4	215	313	1	47.90	50	39.93	CHANGED	saYELYR+So...lGtuLTDuLD-LIssupIsPpLAhKVLtpFDKslscsLp	.....hYpLYRpoT........lG.sLp-oLD-LIpsspIsPpLAhpVLhpFDKulspALt.............	0	74	117	179
+4606	PF02751	TFIIA_gamma_C		Transcription initiation factor IIA, gamma subunit	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4941 (release 5.2)	Domain	Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II.  Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel.	21.20	21.20	22.70	21.50	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.76	0.72	-4.15	26	357	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	277	4	214	301	1	50.30	52	42.76	CHANGED	psKuKloF...K.GcLcTYRFCDsVWTFIl+ssph+h.....................sppplpVDKlKIVACsu	..........pV+s+.loF...K....G+LcTYRFCDsVWTFllpDspF+....................................spphlp.l.D.K.VKIVACsu.................	0	74	115	178
+4607	PF02291	TFIID-31kDa	TFIID-31; 	Transcription initiation factor IID, 31kD subunit	Mian N, Bateman A	anon	Pfam-B_6729 (release 5.2)	Family	This family represents the N-terminus of the 31kD subunit (42kD in  drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation.	29.00	29.00	29.00	29.00	28.90	28.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.48	0.71	-4.36	5	368	2012-10-10 12:36:46	2003-04-07 12:59:11	10	8	276	1	247	382	2	121.40	39	53.69	CHANGED	cuGhoupsccsPKDAplltpIL+-hGIpEYEPRVlsQLL-FAaRYTosILcDApVYucHA+Kusl-.....lEDVRLAlssplspSFTuPPPREhLLcLAs-RNppPLPQI+PsaGlRLPPDRYCLTusNacL+	...........................t.........pphP+DAplht.lLpsh.Gl..s..p..Y.EsRVh.QhL-FA.aR..........YsoslLpDA.....tl.....Y.......u......s..H....A..t+.....s...sls.........................s-DlRLAIpsR.....hshpF..p....s...........s.........P.....P+-...h....Ll-lApp+NphPLP.................h.l..h.........s..........h.......G..R..LP...P.-+asLou.sapl.............................	0	80	126	189
+4608	PF03540	TFIID_30kDa	TFIID_30kD; 	Transcription initiation factor TFIID 23-30kDa subunit	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.00	21.00	21.20	21.00	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.30	0.72	-4.13	20	312	2009-09-14 12:53:53	2003-04-07 12:59:11	8	5	267	0	220	305	3	51.70	52	26.68	CHANGED	PhIPDuVTsaYLs+uGFps.......sDsRlsRLluLAsQKFlSDIAsDAhQau+hRs	......PhIPDAVTsaYLs+uGFps.............sDsRl.hRLluLAsQKFloDIAsDAhQas+hRt.........	0	75	121	180
+4609	PF02002	TFIIE_alpha	TFIIE;	TFIIE alpha subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits TFIIE-alpha Swiss:P29083 and TFIIE-beta Swiss:P29084 and joins the pre-initiation complex after RNA polymerase II and TFIIF [1]. This family consists of the conserved amino terminal region of eukaryotic TFIIE-alpha [2] and proteins from archaebacteria that are presumed to be TFIIE-alpha subunits also Swiss:O29501 [3].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.29	0.72	-4.53	7	544	2012-10-04 14:01:12	2003-04-07 12:59:11	12	13	435	2	355	727	205	102.50	21	29.94	CHANGED	cLlpElltphhG..tcsh.llcsLh.cucso-E-luc.LtlchsplR+lLhpLa-s+Lsca+Rt+D...-ppsWhpYYWhlphc+l.pllKt+hpphlc+LcctLchEps	............................h..lhcthhs....pt..h..hl..l-h.L.h..p..c........s.....t......l.p..-....--luchlph..pt..pplRplLtpL.p.cc+.l.l...p.h...+...p...p...p-.............................p.s.p..s....h..tp.....h......h...a...h..ls.h..c.ph....h....shl.c.h+hpphhpplctp.t................................................................	0	106	199	293
+4610	PF02186	TFIIE_beta		TFIIE beta subunit core domain	Bateman A	anon	[1]	Domain	General transcription factor TFIIE consists of two subunits, TFIIE alpha Pfam:PF02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The structure of the DNA binding core region has been solved [1] and has a winged helix fold.	22.50	22.50	22.70	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.12	0.72	-3.98	12	229	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	199	2	152	218	0	70.60	34	24.23	CHANGED	s+h.s.LthhV-YhKp+.....scPlol-El.shls.hDIsssllshLc.....p.s+lcasscs.papahslasI	.................................a.hshLthlVcahKp+.......scPLol-EIL..-php..lD..l..s.......p....p...hc..phLp............sNsKlchs..c......u.....patFKPhYsl............................	0	38	67	115
+4611	PF02270	TFIIF_beta		Transcription initiation factor IIF, beta subunit	Bateman A, Mian N	anon	Pfam-B_4519 (release 5.2)	Family	Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit  of TFIIF is required for recruitment of RNA polymerase II onto  the promoter.	19.40	19.40	21.20	21.30	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.70	0.70	-4.60	25	473	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	278	10	318	464	4	184.60	23	82.69	CHANGED	stDlDLssuc..p..pVWLVKlPKYLuppW........schssp....tplG+l+Ipps......ttc.pVslhLscp.ps....................plP+EYslphpssp.......spshhVFoEps..t.ppp...p..........................................................pshscKhALtG+Vs+cspshPsts-..pYt+lhpp+.thpsspP++pVphL-ch..Vspshts..suh+usssch...hh......tccKKp-uKpsRhs+p-LLDhLFpsFEcapYWslKsLccpT+.QPcuYLKEsLcpIAhhsK+GPapspapLKPEY++	........................................................................................p............p..thaLh+hP.hl....p...tW...........................tt......t...........luplhh..t.................thth...ht................................................................hPppa.h.......h.t................................s.hlhsp...............................................................................................tph.h.Ghl.p..ch.p....hhP.................p............p.....pa..p.hh.t.p.....t......p....t.l...pp............t.h..........t.h..t.t...........................................pttt.+thR..hspptl.shlathFc.c.......h...ash+tLht.h..........p.QP.................a......L+phLppls.h.hp.s....t..h.apL+s-hp.....................	3	103	173	251
+4612	PF01096	TFIIS_C	TFIIS; 	Transcription factor S-II (TFIIS)	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.20	0.72	-4.32	109	1781	2012-10-03 10:42:43	2003-04-07 12:59:11	13	25	640	94	1065	1584	290	39.10	43	20.94	CHANGED	hpCs.c...Cspccshah.phQpRSADEP.ThFapCh..pCsppW+	...........pCs..+....C.....t.p.c.c.s..hah.phQ......oRS...A..DEP.hTs....Fap.Cs..pCup+W+..........	0	343	578	851
+4613	PF04994	TfoX_C		TfoX C-terminal domain	Bateman A	anon	COG3070	Domain	TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes [1]. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with Pfam:PF00383 in Swiss:Q9JZR1.  It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.	23.00	23.00	23.00	23.30	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.50	0.72	-4.07	48	1181	2012-10-03 02:11:09	2003-04-07 12:59:11	8	3	1046	4	158	663	24	79.70	38	45.23	CHANGED	tssR.L+-......LPNlshshEchLp+sGIcolppLcplGAhpuah+l+ps.utslslpL...LauLpGAlpGhHWsslsppc+pcLlpth	................t..pRL+D......LPNhuhplEphLtcsGIcslcpL+tlGActsal+.L+pp....sstlohcl...LatLEGAI.GlH.ss.LPts++pELhch...........................................	0	37	78	123
+4614	PF04993	TfoX_N		TfoX N-terminal domain	Bateman A	anon	COG3070	Domain	TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes [1]. This family corresponds to the N-terminal presumed domain of TfoX. The domain is found as an isolated domain in some proteins suggesting this is an autonomous domain.	22.20	22.20	22.20	22.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.02	0.72	-4.14	85	1775	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1572	2	258	995	70	89.90	27	59.84	CHANGED	lh-hl....ush.GslstRpMFGGaGlah.cuhhFAllsc.s...pLaL+u.sspspsha.pstGs....tsata..tpth.h....shsYaplstphh--tptltphs+huhpsuhp	....................c.lstL..us..lph..RsMFGuYulah.cs.......s.l.h.uhlh-....s......cLal+u.scpstphh..sppss....hsash.....th.......shpaahlstphhc.....st..Lhph.chuhpth..............................	0	60	131	199
+4615	PF00019	TGF_beta	TGF-beta; 	Transforming growth factor beta like domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.30	20.30	20.60	20.40	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.86	0.72	-3.76	20	3712	2012-10-02 16:54:34	2003-04-07 12:59:11	15	19	848	111	1288	3220	0	95.50	38	29.32	CHANGED	sssCph+pLalsFp.DlGWspWIluPcGYhApYCpGpCsaslssphsso....spAllpsls+hh..tP.pssspPCClPT..cLsslohLahD-sps.hhl+phpsMlVcpCGCp	............................p.ptCp++sLaVsFp.-l.G..W.s.p...W.IlA...P.pu.YpAhYCpGp.Cs.a...sh.s.s.ph..sso........................sps.h...lp.s..l.h..............pth...........s.s......s..s.spsC..Cl..Po..chssloh.LYh...-..p....p....pp......hh..hc..ph.sMllptCuC.....................................................	0	194	298	677
+4616	PF00688	TGFb_propeptide		TGF-beta propeptide	Bateman A	anon	Pfam-B_110 (release 2.1)	Family	This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.43	0.70	-5.08	81	3044	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	870	4	1012	2611	12	185.70	18	54.29	CHANGED	sl...........................................s.h....tpthpppphcthcpplLphlGLp..cp...Pps............ttstssP...pah.L.-LYptht..............tppsttpss.........t...t......................usolhoFtsctphpp..........ptptpphhFslSsl...sps.cplstA-.L+lahpt..............sspspphplplaplhp.........tttt.pcLLss+h...lphs.....suWpsFDloss.lpp..Whppspp..NhG.....ltlpl.......hstct.sshssp..t.....t......................tptpPhLlsa	..............................................................................................................................................................................................................s.............h..t.ht......................................................................................................................................sp.l...ht..h............................................h.hFs.h.o....th........pt..p.......l..tAp.lh....lah.t.............................................tttthplp.lhph..t.....................ttt.....tph..lsp+h...........lphpt.................stW....sF..D.V.o..s.....s.lpp...Wh.......tpsp.......s..hG......l.lp.s.......................p...pt...pt.....t..........................................................t.pPhh.h..................................................................................................................................................	0	166	252	544
+4617	PF01702	TGT		Queuine tRNA-ribosyltransferase	Bashton M, Bateman A	anon	Pfam-B_1643 (release 4.1)	Family	This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine,  aspartic acid, histidine and tyrosine with queuine.  It catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol  moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified  base queuine in the wobble position [1,2]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H,  and important tRNA and 7-aminomethyl-7deazaguanine binding residues [1].	23.80	23.80	23.90	23.90	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.52	0.70	-5.08	133	5152	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	4473	77	1485	3705	2879	234.20	41	60.66	CHANGED	Ecsl.plQpsl.GuD...IhhshDcss...sh.....ss...st.ctscpuhccTh+Wsc+shpth..............................ttpppsLFGIlQGGha.-...LRppusctlt.p...........s..hsGaA......lGGlusGE......sp.pphhpllc.hsss.......hLP............ps+PRYL.hGlG.pPtslltuVthGlDhFDClhPo.RhARpGphh...TppG............................................pl.............plcst.patpD..pPl..-.sCsChsC.............p.......paoRAYl+HLhpspEhlu.pLlohHNltahhplhpplRpuIpps.pht....phhpp......hhp	..........................................................................................................Ecuh.pIQps.L.GS.D..IhM.hF.DECs.......sh............ss.....sh..chsc...cSh-ho.....hR..WAcRshcta........................................phspppu..LFG...IlQ..GuhacD...LRc.pS...scsLs.p.............t..FsGYA........lGGLu.VGE............s+..ppMh.c......ll-...hsss..........hLP.........................................pc..KPR...YL..MG.VG..pP-......sLl.....-u.V.t.+.G.lD.M.FD..........CVhPT.Rs.A....RNGphh.TspG....................................................................................................................pl.........pl+NA..catpDh.pPl...D....p.Cs..C.YoC......................................p...........s.YS.RAYL+HLh+sp....E....h..........l....G....hpLsolHNLpah.pLMpplRpAItp..s..p..htpFhppFh.t......................................................................................................................................................................	0	514	934	1253
+4618	PF04858	TH1		TH1 protein	Kerrison ND	anon	Pfam-B_6070 (release 7.6)	Family	TH1 is a highly conserved but uncharacterised metazoan protein.  No homologue has been identified in Caenorhabditis elegans [1].  TH1 binds specifically to A-Raf kinase [2].	20.00	20.00	22.40	21.10	18.70	18.00	hmmbuild  -o /dev/null HMM SEED	584	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.84	0.70	-6.36	5	182	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	117	0	129	184	0	427.00	40	78.05	CHANGED	Ms-DaEs.scuWspusGcGpttu--supuE..sEsssuVlpECLc+FuT+DYIMEPuIFssLKRYFQAGGoPEsVIphLSENY+AVAQMsNLLAEWLIlTG.......VcPscVQAsVENH.............................................LKsLllK+FDP+KADuIFTEEGETPAWL-pMIcHcTWRuLlY+LAEcaP-CLMLNFTIK................LISDAGaQuEITSlS.TAAQQlEVFSRVL+TuIssILsuGsDDl++s..IEElA+MVCHGpHTYVFuQlMluVLuQEpcGGos......s+RLSQEIp+aAtcpspsATsITlA..LuuSAsaPpACpALuuMLSR................GALNPADITVLa+hYoSSD...PPPV-LIRsPsFL-LLlsuLFKsGVKI.Ns-HKuKYhaLLAYAASVh-..tKp.ps..-cslsKDELKuT..AIEcAHAIhCNss+GsSELlA-lsTLYsCI+aPVVusGVI+WV-ssVTEPuYF+LsT..-osPVHLAlLDEVAssHsuLQsQVLcLLl+LFE....S+pDEL-Ih.QLEhKKsLLDRMVcLLARGaVlPVloYlspChcR.DTDlSLIRYFVTEVLElluPPYSsDFVQLFLPlLEN-sIsGoM+uEG-sDPVoEFI..VHCKu+ahol	..................................................................................................t..t.h..pcthpth.p.DhIME.Pslhs.....lp..pYhps........GG..sP...pp..........llphLSpsYpuhAQhssLlucWLh.hs....................hp..plpthhcsp................................................LKphlhcpFDPpKADslF.otp...u...p.....sPtWL.pphI....t..................c.pWRpL...hYpLAE..t.aPc...CLhLsFsl+...................hI.SDAGaQs...EIsSlo..TAspphpVFo+VLpsslsphlp........s.....p.-.s.hpps....l.-hs+hlCpupHTYlauQshhph......Lspc....t.ps.s.s................h+Rlu...QElpp.A.ppt.psss.........hphs...........Lssu...s........t......s...ps.....ppulsuhLsp...............................ssL...ssuDlp.hLac..as.s.c......PPPlphlR..Pthl-lhh..psLFp.s.u.pl....s........ca+.cahalLAYAussh-......tpt..p........................hsp..-..-.lcs.......T..pAlEp....spsl.p..s.s..tu.t.....s...chh.uplt.pLhpsl.chPlVuhGVl+Wlc.sl..ps.p.aa..p..h.s....-psP.haLslL.-ElsshH.hhp.plLplLhplh-..............spt.s.pl-hh.th.Eh++hllD+hVpLlo..pGhVlPVl.............palpps.htp.phDhSLIRaFVoEV.....................L-hlsPPYos-Flphalshlpstplh.ssh.........t.....ht.Fh...................................................................................................	0	63	75	106
+4619	PF00314	Thaumatin	thaumatin; 	Thaumatin family	Finn RD	anon	Prosite	Domain	\N	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.25	0.70	-4.87	124	1409	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	247	50	615	1398	11	174.60	39	73.41	CHANGED	NpCsaTVWPushss...u............GGhpLssGpo..hsls...sPsu..h.uGRlWuRTsCsFsu.............u..pupCtTGDC..G..GtLpCs.G.s.GtPPsTLAEaoL..........t...t......DFYDlS.LVDGaNlPhslsPp...........s....sC.....ssuCss.....................................-lsspCPs-Lps......................................uCpSAC...........ts.....FtsspYCC.....ts.ststsCt....PotYSphFKptC..PcAYSYAhDDsoSo..FTCs.....u...ss.YplsF..C.P	......................................................................NpCsaTVWsuhhss.........s...................sG..ht..L...s.Gpo...hsls....ss..ss.....h..uGRhWu........RTsCshss......................sG..phpCtT..GDC....u..G.....hl.....pCp...u..s...ut.P...P.s.TLA..EasL...................st..ss....Da..YD...l.S.LVDG.a.NlPhthsPp...................t...sssC....psssCss..............................................................................................................................................s.ls.t.....CPsp..Lps.....................sh................uCps.sC..................................s.....a.t.p.sph.CC............................s.......tsC.......................so....a..SphF.Kp.t.C.P.pAYSYshD.D.....o....os......ao.Cs........s......ssY.lhF.C.............................................................................................................	0	129	377	515
+4620	PF01946	Thi4		Thi4 family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.60	0.70	-5.26	8	671	2012-10-10 17:06:42	2003-04-07 12:59:11	12	29	532	20	351	23606	13980	162.40	35	48.14	CHANGED	SRAhscpYacDLlcYAEoDVlIVGAGsSGLoAAYYLAKp..sLKVAIlEpplS.GGGsWhGG.LFsthVVc+PA+thLcElGItYE-pschhlVtcAA.FsSTlhSKslp.sslKlFNussVEDLIlR-......spVuGVVhNWohVphu..H.....hDP.TIcA+...............lVlsuTGHDushuuhsVKRl..h.ts..tclsG.+uh.hspAEcslV..+sTREVhPGLaVuGMtlutlcGAsRMGPhF	..........................................................t.........h....p.....h...c..h..D...VlIVGAGsuGLs.uA...h...h...L......u...ct.........sl....+....l.s.l..l...E......p........p......h.......t...........G.......G........s......h..............h..........h........G.......u...........h.....h...........................h.................h................h....p......t........................................h..........h...................t....h.........t...........h.........................................................................h.....................................................................h........h.................h..............s.h...h.........h......hp...D.lh.h.........................l......u.h.................................................................h.DP......h....................hhht.sG.H..s..............pp............................................................................t..s.h....uE..hh......s.....................................................................................................................................................................................................................................	0	103	208	290
+4621	PF01964	ThiC		ThiC family	Enright A, Ouzounis C, Morett E, Bateman A	anon	Enright A	Family	ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis [1]. The precise catalytic function of ThiC is still not known. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis.	25.00	25.00	27.60	27.60	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.32	0.70	-5.96	113	2842	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	2688	6	832	2312	704	430.20	62	77.26	CHANGED	TQhchA+cGllTtEMchVApcEsls..................................sEhlRpplApG+llIPsNhsH...phcPhuIGcuhpsKlNANIGsSsstssl-pEl-KhchAhcaGADTlMDLSTGG.clcplRctIlcso.slPlGTVPlYQAh....tchpstlh-ho.-.hhcslccQAcpGVDahTlHsGlshchlpthptt.pRlhGIVSRGGSlhsuWMhtppcENPLYppFDclLEIh+cYDVolSLGDGLRPGsltDAoDpAQhtELhsLGELscRAhctsVQVMlEG.PGHVPlspIctNlclpKclCcsAPFYlLGPLVTDIAPGYDHIouAIGuAlAuhtGAshLCYVTPuEHLuLPsh-DV+EGlIAtKIAAHAADlAKs..hssAp.c+DptMucARtshDWccQFpLulDP-+A+ph+ccshst......pschCoMCG.caCuh..+lspchh	..........................................TQhcYARpGIITsEMEalAlRE.N.h.s.............................................................................sEFVRcEVApGRAIIPANIN.H...PE...E.PMIIGRsFhVKlNANIGNSAloSSI-EEVEKlsWAhRWGA.DTlMDLSTG.c.pIH-..............TREWIlRNS.PVPIGTVPIYQAL....EKVsGhsE-L.TWEh.FRDTLlEQAEQGVDYFTIHAGVhL+alPhTA...cRlTGIVSRGGSIMApWCLs.HH..pENFLYpHF-EICEIhttYDVohSLGDGLRPGSItDANDcAQFuELcTLGELT+hAWca.DVQVMIEG.PGHVPMphIcpNMchphchCcEAPFYTLGPLsTDIAPGYDHITSuIGAAhIGWaGs.A.MLCYVTPKEHLG.LPN+-DV.Kp...GlIsYKIAAHAADLAKG...HPG.Ap.hRDsA..hSKARFEFRW-DQFsLuLDP-pARtaHDETLPp-s...........tKsAHFCSMCGPKFCSM+Iop-lR.......................	0	268	553	714
+4622	PF02568	ThiI		Thiamine biosynthesis protein (ThiI)	Mian N, Bateman A	anon	COGs	Family	ThiI is required for thiazole synthesis, required for thiamine biosynthesis [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.08	0.71	-4.86	8	2899	2012-10-02 18:00:56	2003-04-07 12:59:11	9	10	2786	3	551	4081	1379	188.10	39	45.56	CHANGED	GopG+VLuLLSGGIDSPVAuahhhpRGscVshlaFhstshpstcshcKlc+LAplLucaps.hph+LhVhsapclQc-lhc+s....sEshpsVlh+RsMh+lAphhAcchsscAlVTG-uLGQVASQTL-NLpVIpsso.shsIlRPLIGhDK--IlclAKcIGTa-ISIc.c.-sCohhs.K+PsT+AchppVcKhcpclph	................................Tpt+slhL.lSGGlDSs.VAuYhh..h.+....R...G...l...c..lch.l.a...F..................s...h.......s.....u....s....p.......s..h.......t...+......s....p......s........h......t...p....h.....h.....s....c.....a...u........u.................p......l.......c.....h......h....t....V......s.....F.....s.....p...l..........t.....c..I..h....ccs.................sc...s.......h....h.......l.l.......h...+.R..h.....M..h.Rh.A.s..c..l..s..c.c.h...s.s......u.l...l..TG.......E..u.....L......G.........Q..V........u......S.........Q......T......L..p......s..........h.p..............s....I...s..s.........V....o..........s...........s.............lL..R....PL..l..s.......h.......D..Kp-IIplAccI...sT.......-huhp....-hCsl.hs..cpPpscshhpchpt.Etph.........................................................................................................................................	0	185	341	458
+4623	PF00975	Thioesterase		Thioesterase domain	Finn RD, Bateman A	anon	Pfam-B_180 (release 3.0)	Family	Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics.  Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates.  There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.24	0.70	-4.13	38	5677	2012-10-03 11:45:05	2003-04-07 12:59:11	15	590	2120	48	1644	8115	689	222.20	18	14.88	CHANGED	tpLhshP.uuG.usphapsluptlss....hshtslphsuct.......hpshpplscthhstlpphtscs...PaslhGaShGuhlAaElAppLppp...GhtspsLhlhst.sPhh.sttttstthspst...............hhsthpchsth...st.hhtspphhtthlssltushpshtsht.............thshpt...........................hthhhtssc.hsshs....spt.............Wpphsstshp..hchhsGsHFhlhp...t....plhptlpptl	.......................................................................Lash......s..u..u...G..sshta...t.s..l....sp....t....Lssp.......hslh..u..l..p.....h.suht.............tt.............h....p....s.....l.....p........p...h......s....p....t......h.......h...p...t...l..........t..........p.....h...........t...........s.....p............s........P............a............h.............L.h.Ga.S.h.Guh..lA..a-...h.A.........p...p....Lppp.........Gp.p.......l...t.tL..h...l...h.....-....s.....h...s.....P..t...h.....t........t...t...t.......t...t...h.ttt.t....................................................................hhttht..p.ht.th...........s.t..h....h.t..p....t....t...h..h.......t.....h..h....h...s..h....h...t.....s...s..h.t...h..h..t.ph...t.........................................................................................h.hh.h.h...s.t....t.....s............s....h..t.............t...............................................................................W.t.t.h.h.t....t.t.ht.......hh..h...s.u.s..H.h.hht....................h................................................................................................................................................................................	0	397	893	1351
+4624	PF01289	Thiol_cytolysin		Thiol-activated cytolysin	Finn RD, Bateman A	anon	Prostie	Family	\N	19.60	19.60	20.70	20.50	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.59	0.70	-6.12	5	995	2012-10-01 20:08:01	2003-04-07 12:59:11	14	5	457	12	47	624	8	335.40	41	87.32	CHANGED	ss-pIDcaItGLNYNKNcVLsapGEuIcNhsPKEGhKcuscFIVVERKKKSINTNsuDISVlsSloSRTYPGALllANc-LlENQPDlLsVKRcPlTlSIDLPGMsNpDNpIsVpNPTpSNVssAVNsLVs+Ws-KYSpsa.NlPARlQY--pMAYScSQLpAKFGssFKslNNSLsIDFsAIScGEKQlpVluFKQIYYTVSVNtPsNPSDlFsKSVThE-LQp+GVSAEsPPlYISSVAYGRsVYVKLEToSKSs-VcAAF-AAlKGsSVpussEacsIl-NSSFKAVILGGDAp-cscVVTGDlsslRDlIK-GAsFo+KNPGlPISYTTsFLKDNplAsV+NNTEYIETTSTAYocGKINLDHSGAYVAQFpIoWDElSYDscGpEVVT+KsWDcNs+DKoAHFTTSIPLPGNARNIsIaARECTGLAWEWWRTVlD-RNLPLVKcRNVSIWGTTLYPpsSsTV	....................................................................................................................................................................................................................t.hasuul..ssp.h....ps...t.l.....h.t.ht..phphs.Lsu......s.h..h.p...ss.ushttu.lsplltph..t.t.....t.......sphpYp...s.o.ppl......th..s..ssh.....p....h.......ht..s.sltlsFt....ul.....tp.Gchp..........l.......hsaKQI...a...YsVss..s...sp.pPuch..FtpsVThcpLpthGlsspt..P..salSsVuYGRplYlKLp.Ts....S...+....S....p..c........Vp....A........A....FcAh...l...p........s....h....p....l..t..s....p....s....p..h....p..pI..h....c....pophpAVlhGGssp.ptsp....ll...s.t.p.......hs..l.c...sllp..csup.a.stc..pPuhP.IuYTosFL+DN.....hAs..h.pN.s..o-Y..l.ETps.p.tYpsucl.slDHSGAYVApa.IoW-ElsaDppGpEllp.+sW-tNspshTAtFspsI.l.tN........hRNlplhhccpTGLhWphWpTlh-ppsl.h..phplohhGTTL.sphp.................................................................	0	13	36	41
+4625	PF00108	Thiolase_N	thiolase; 	Thiolase, N-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Thiolase is reported to be structurally related to beta-ketoacyl  synthase (Pfam:PF00109), and also chalcone synthase.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.71	0.70	-5.41	22	14120	2012-10-02 12:25:54	2003-04-07 12:59:11	18	36	3652	158	4432	24361	7473	245.80	34	62.42	CHANGED	hcsVVIVuAsRTPlG.uatGuhpshsAs-Luuhslcuslc+ss..lssp..pVs-lIhGsVLpuut.GpssARpAuLtAGlPpplPAhTlN+lCuSGLpAlshuuQtItsGpu-lllAGGhEsMSpsPahh.....+sGh+hG.sh.hhD.hl..............hDuLhsshsthhMGlTAENlAcpasISRcpQDpFAlpSppKAttAhpsGpFpsEIlPVpl....p+Gc...hslspDEt.R.ssThEsLupL+PAFpKt.GTVTAGNAStlsDGAAAlllMocs	......................................................................................ppssIls.uhRTP......h..........G....p.......h........t......G.........uh.....p..s...h..p..s.s-...L...uu..................hsl...c...s...h...lp.R...........s..................s.....l.s.s.p.................tl...-....-....V....l.........h..............G....s......V...h..p......s...u..........p.......G...t....s....h...A..R.p...u.......u....l......t...A.......G...........l..P............s......l........s...u...hT......l......N..+h...CuS.Gh.pA............lth...AuptIt....s.......G.....p.s.-....ls.l..A.GGs...E....s..M...S..p..s.P..h.hh...............p....h.s.....h..p...h.....s.....p...............s.t..hh....................................s..s....h....t...s....h.....h.....s....t......h......t......M...G.......o..A..E..p.........l...A..........c..p.....a........s.............l..oR....-....p.Q............Dta.A......h.pSp.p.+.................Att..A..h..p..s.G....h.F..........p.....p.E..I..l..Pl...ph...............tp....G....t......................hhhs..p.....D........Et...R......s.........t.........oo.........h..E.t.........L.up.L.........+..P...s.....F.....p..........t......t......................G.................o..........V......................T.A...............GN.uSslsDG.AuAlllhoc.............................................................................................................................	0	1259	2619	3654
+4626	PF02803	Thiolase_C	thiolase_C; 	Thiolase, C-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Thiolase is reported to be structurally related to beta-ketoacyl  synthase (Pfam:PF00109), and also chalcone synthase.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.41	0.71	-4.69	22	14316	2012-10-02 12:25:54	2003-04-07 12:59:11	13	37	3621	158	4583	11836	4437	125.10	38	31.49	CHANGED	lpPLA+IhuaussGVsP.plMGhGPs.Asp+sLc+AGls.lsDlDlhEhNEAFAuQsLust+plshD..................pKVNlpGGAIALGHPlGsSGARIlsTLlpphpccs.uphGlAohCIGGGtGsAhllE+	.................................................h.pPhAcl..h..uhussGs.........-........P....phM...s..h..G.P..s......A.s...p.......+.sLc+.....u.G.......ls....l....s.D....l....DlhE...........lNE....AFA.....u.......Q.sL.us.h...+...p...L.....u......l...s..t.............................................p..+..l..Nl.sGGAIA.lGHPlGAo.......G.......ARlls.oLlpp.......L.......c.......+............c..............s.......s.............p.............h..........G......l......s......o.....h....C..l..G..GG.GhAhllE.........................................	0	1267	2699	3788
+4627	PF00085	Thioredoxin	thiored; 	Thioredoxin	Sonnhammer ELL, Eddy SR	anon	Prosite	Domain	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.57	0.72	-4.35	50	24231	2012-10-03 14:45:55	2003-04-07 12:59:11	15	236	5259	369	9501	25842	8046	102.30	23	50.59	CHANGED	slhhlssps..Fcphltp....s...c.VlV-FaAsWCG.CKtlAPha-clApchpt.....slhlsKlDss.cs..tsluscasVcuhPTlhha+sGptss..chsGu.hstsslhphlppp	.................................................h...hstts.a..p.p.....l....t.p............p...........t..s.l..ll........c.....F..a.....A....s......W..........C...u......s....C.....+....t...l......s......P......h....h.......c...c...l...u...p...c...hpt...........................pl...p..h..s....+.........l.......-...........s...........-........p......p........................p..............l......s.................p.....p......a......s..........l......p........u......l......P.T...l..h......h....a.......c.......s......G....p.......ht...........ph........Gs....hs.tp.tl.tphlt..t......................................................................................	0	3323	5599	7830
+4628	PF00585	Thr_dehydrat_C	Thr_dehydratase_C;	C-terminal regulatory domain of Threonine dehydratase	Bateman A	anon	Bateman A	Domain	Threonine dehydratases Pfam:PF00291 all contain a carboxy terminal region.  This region may have a regulatory role. Some members contain two copies of this region. This family is homologous to the Pfam:PF01842 domain.	20.80	20.80	21.20	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.83	0.72	-4.39	16	4280	2012-10-02 00:29:19	2003-04-07 12:59:11	13	7	2590	4	1023	2991	981	90.50	33	30.33	CHANGED	EtstlttspEtlhshphPEcsGuLh+Flpslush.s.IThFcYRtpss.cpuplLsGlplsptp-..s-hhpplpchuassh-hosscshphaL	................ERs.htptpEtlaslpFPEcPGALhcFl.p.tl....u....s...c........s..IThFpY.R.......p......p........s......s....c.......t......u..........plllGl..p....l.....s.....p.....s...p-...htplhp.pL..p..p.h...G..........a.shhDlocsphh+hal...........................................	0	240	560	825
+4629	PF04163	Tht1		Tht1-like nuclear fusion protein 	Wood V, Finn RD	anon	Pfam-B_64620 (release 7.3);	Family	\N	21.00	21.00	21.10	21.00	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	544	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-13.13	0.70	-6.11	2	96	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	92	0	70	102	1	333.90	18	73.00	CHANGED	.hF..hR...hha.FhIhIpFh.oSE.hGclpshhphp.lhao-s.suhssLtpha...hhKSTChp-shthhlspC.lhNs..oID..sRlcoAIpholC-FptStl..hPppChh...GS..-Ch.cLESoSpWWhoaoupapclsplCh.s.L.hpKE..lcl.hNlT.l.cpF...l-hhl.HLh.Fp..pDp.N.hlDchsthF.N.s.E.p.ts.s.Rl..E..sLs.hpN.....hVp.c.lhpT.cQLcspIh-hNS.hhN...Essshp.plhpcLs-chs.cNsIt.StIschps-..s.hpc....LlphopD.lpp.hppN.chVNo....L.shohtLKcpLtuhp+..SEpQ.hpt.plLQhhsshLpsSh...hs.p.l..hhshhpphhp.ahthhSsl.usFAhhs.plFuThssl..chLphp++.l.sh.plpl.hlHh.shhhh.hV..ahWhT.phIhR.hualtlp.+haaL...LCull.al.a.KYRsS+hssch...lPh.c....Ya.pahtl..s.YLsshpsSLIDh	...................................................................................................h....................................................................................Chp.Aht...hh.pC..h.....pu.....p..s....l..s.............tphp..s.....AhpLulCEhpsus.h..phPppC.s..............................t.p.h.ts...ClpsLEu.ssQaWToYSushpphsshC..ptsphshEK....-phLpla...pslTclhpph..........h.pt.h...p.p.hh........p...p.p.p.pt.p.....h....h...ppltthh.p..............p..............t...p....t.....p...h....t..............h........htt..........................h..p.............t.....h.t............................................................h....................................................................................................................................................................................................................................................................................................................................................................t...........................................................................................................................................................................................................................................................................................	0	17	39	61
+4630	PF02926	THUMP		THUMP domain	Aravind L	anon	Aravind L	Domain	The THUMP domain is named after after thiouridine synthases, methylases and PSUSs [1]. The THUMP domain consists of about 110 amino acid residues.  The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains [2]. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.63	0.71	-4.31	48	6107	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	3468	22	1490	4208	349	137.50	18	30.26	CHANGED	pclpphh.t.thphphh.tthttlhlhhst.....ttptltphhthh...........hl.ph..h...........hts.tsh-clhctstplhpcphht........oFtVcscptspp................phsuh-lpctlGphlhcphs........pVcLppPDllltlElhpp.pshltlpp	...................................................................................................................................hh..........................t.h.l..t...t............shptlhc.....shhhlh................................shp+.lh..s.........................tphsh.p.....s..h..c.-.la.p.t.s.h..s...l.sh...pph.hsht........................TF.sV....p.....scptscph...............................pass.hclpc.hlssulhcpht..............................pspVsh...p.s...P.....D.....lp...lplpl.pc-..tshl.h......................................	1	431	822	1180
+4631	PF02511	Thy1		Thymidylate synthase complementing protein	Mian N, Bateman A	anon	Pfam-B_1648 (release 5.4)	Family	Thymidylate synthase complementing protein (Thy1) complements the thymidine growth requirement of the organisms in which it is found, but shows no homology to thymidylate synthase.	20.10	20.10	20.40	20.30	19.60	19.90	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.35	0.71	-4.94	163	1591	2009-09-11 08:36:29	2003-04-07 12:59:11	10	9	1413	90	459	1297	3344	199.20	24	79.78	CHANGED	Vp...........Llsh....................s........s....s-phlstAARssass...........tph.st................................................tcspthl.chlhc..puH.....hSshEass....hoFtlc.soRuls+QllRHRh.hSa.sphSpRYs.......................................................p.hpph..t.........ahl.P......phpp.s....................htp...hhpcthppuh..................................ctYpcll.pt..........................u......hup....EtARhlLP..ustTclhhohNhRsLh+.FlpLRss........ppAQh.EIRplAtthhc.hlpc...hhPhl	......................................................................................................ss.thh..AuRhsats.......................ph.t..........................ppspthl.chl.hc......htH..............tSs..hEass....hoFtlp.lS+sst+..pl..hR......HRh..sSh.......s..phSp..RYs...................................................................p.hpp......p....................ahl.P................phpp.t...............................................tht.chhpp..sh..ppuh...................................csYppll...pt................................................................................s.hup......EhA.RhlL.P..tu.hpTchhhohNhRs.Lhp...Flp..LR.s.s........pc.A...ph...EIRp.lAtthhch.ltphhP..h................................................	0	198	347	413
+4632	PF00303	Thymidylat_synt	thymidylat_synt; 	Thymidylate synthase	Finn RD	anon	Prosite	Domain	Swiss:P28176 is not included as a member of this family, Although annotated as such there is no significant sequence similarity to other members.	20.60	20.60	21.20	20.70	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.71	0.70	-5.39	141	4583	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	4044	372	1007	3278	1831	266.00	44	92.72	CHANGED	-ptYLcllccIl.......cpGpp+..........sDRTGsG...ThS.lFG..hphRac.Lpcs.......................FPLL.TTK...+Vah+ullpELLW.FlpGsTssphLp.....pp.sl+IW-t.u..............pph...............................................p.G-L.......GPlYGhQWRc...ass.............s..........................pt..lDQlpplIcpl.Ks........NPsSRRhllsA..........WNssDl.......spMALPPCHhhhQFaVs.............................c..G+...............................LSCpLYQRSsDhhLGlP.FNIASYuLLTcMlAphs.....G.....LcsG-FlHshGDsHlY..................................................pNHl-..tl.cpQLpR..pPpshPpLpl....p.....php.......sl.ca....ph-Dhp..l.sYpsas.tIc...................h.hAV	.................................................................................................h.ptYl-Lhpc.lL.......cpGs..+..........................sD.RTGo.G.....ThS.l.FG..tQhRFs...LpcG.......................FPLl.TTK......+lhh+ullpELLW..FlcG.sT.......NlphLp...........cp.slpIWD.-WAscs........................................................................................................................................G-L.........Gs.V..YGh.QWRp...Wss....................G.............................................................................................................................pt.lD.Qlpp.llcpl...K..p........s.P.s.S...R.RhI.....lSA...................W.Nss.-l...................cpMALsP.CH.s..haQF..Y..Vs........................................c..G+..........................................................LSCpLYQRSsDlaLGlP...F.N.IASY.A.L.....Ls.pMl....Ap.s..............G.......L.c........sG-FlaohGDsHlY....................................................pN.Hh..-..p..s..c...Q..Ls............R............-P..t...s.h..P...pLhl.............s....csc.........................slaDa..............ph-Dhp....l.sY..csHs.tIK.hslAl......................................................................................................	0	318	610	831
+4633	PF02223	Thymidylate_kin		Thymidylate kinase	Bateman A	anon	Pfam-B_484 (release 5.2)	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.27	0.71	-4.92	25	5133	2012-10-05 12:31:08	2003-04-07 12:59:11	12	17	4611	113	1395	4369	2991	185.50	31	82.85	CHANGED	lEGlDGuGKTTpsphltctLpspuht..hhho+EPsuo.lGchlRphLh....ptphsshs...tslLFsAsRhpclt...phItssLppuphVIsDRahhSolAYQuh.tpt..hchlhplspsshh....pPDlslhL-.lsschulpRhpt+sp......ch.tcphchhpph+ptahcLsp..spphhllcAsps.lEplpppI	....................................................................................................hEGh-GuGKoTt....h....p....h..l....h....p.t.L........p....p.............p..........G............h.............p.......hl.......h..TR.E....P......G...G....o.......l......u......E....p.l...R.pllL...........pspp.h.ssps...............EhLLah..A.u..R..tpclt.............ph.I....t..P.....A...L....p.....p....G..p......h..V.........l......s............DR.....a.........h.....s......S.o........hA........Y.............Q........G......s........u........R......s.................l.............s.............h..........p..........h.........l.....t............p.....l........p.....p........h.....s..........hts........hpP............D.L..T....laLD..lss.-...h....u....h....p....R....ht.t.psp.....................s...Rh-.p...E..s....h....c.....F....a...p...+....l....+p.t...Y...h....p........l...s....p.........t.....s..p.......c..........h.......h..h..l...D.A.....s....ps..h-pVhp..................................................................................	0	460	873	1164
+4634	PF01290	Thymosin		Thymosin beta-4 family	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	22.30	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-8.06	0.72	-4.36	25	536	2009-01-15 18:05:59	2003-04-07 12:59:11	15	14	139	15	223	588	0	39.70	49	73.45	CHANGED	uDcPchsE.....lssFDKscLKKTETpEKNsLPTKEs.I-QEKptp	....................thsE......lEpFDpsKLK+TETpEKNsLPoKEsIcpEKpt.........	0	80	94	160
+4635	PF00086	Thyroglobulin_1	thyroglobulin_1; 	Thyroglobulin type-1 repeat	Bateman A, Sonnhammer ELL	anon	Swissprot_feature_table	Domain	Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation [2]. The domain usually contains six conserved cysteines.  These form three disulphide bridges.  Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.	20.60	20.60	21.30	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.01	0.72	-4.62	20	2274	2009-01-15 18:05:59	2003-04-07 12:59:11	13	161	191	10	1102	2134	3	67.10	28	20.34	CHANGED	Cphphtph...h............tpsspshYlPsCc.ccGpYpshQCp.....ppG.CWCVDst.GpclsGo.ptpGc..spC	.......................................................................ttthtsha...l.P..p.Cc..cpG..t..ap.s............h.Q.Cc.............................psG..hCWCVDtp..G.ppl.s.G...o...p.h.t..sp..spC................................	0	270	360	665
+4636	PF04278	Tic22		Tic22-like family	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The preprotein translocation at the inner envelope membrane of  chloroplasts so far involves five proteins: Tic110, Tic55,  Tic40, Tic22 (this family) and Tic20. The molecular function of  these proteins has not yet been established [1]. 	20.10	20.10	20.50	20.60	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.49	0.70	-5.14	13	173	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	89	1	101	185	2	211.40	21	70.51	CHANGED	hp.s...............................t..t..psh.R.shsh.......hhhsshAhuu.hsstt.........t.AhuLot..........c-Vhc+LsuVPVFTlssosspPlLsospst....spSluhlalsppDAcsh.Lspl+pppP................-h.upsspVssloLuplYclspt.tt.........csptlsFpFlP-spQlcsAhplhcpsGpph.spFpGVPlFhucu..........LslppcscphhPhFFsK..........EDLpttLc+hppppsclssuhp...IcVssLEsllcshcsuc.ssth-cllFIPPtcul-ah.pphpp	...................................................................................................h..h..........................................................................................shs...........tpl.phLtslPVahlsstps....t..l.....hht..p..................ttls.h...hhh..ptp-Apth.lt.....p.lpt.....tp..............................h..ttthpVhslsL..sps.Y.ph..............................pspsl.hFpalPs.ppl.......psAh.......pl.hpp..p......spt...pt...........ht..G......V....P.lF.scs...............L..sl..p...p.t....s.....c.p........hhPhFFpK...................pslpp.lpph.ppp.p.....t..........t.p....I...tVhslpslltthp.p.....p..pt.hpphhhlPst...ht........t........................................	0	33	73	93
+4637	PF01826	TIL		Trypsin Inhibitor like cysteine rich domain	Bateman A	anon	Bateman A	Domain	This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.41	0.72	-3.85	167	3970	2009-09-12 21:20:27	2003-04-07 12:59:11	12	461	156	15	2435	3452	1	56.00	32	11.06	CHANGED	C.s..ssppap.pC..ss..sC..toCsshps........Cs.........tt..ChtG..C....h....C..psG.al..hsss......pCV.hscC	..............................C.s..sspt.a...p...tC......ss...........sC..st..oCpshsss.................Cs...................pt..C..h...pG..C......h........C..............ss..G...hl.........hsss........pCVshppC.............................	0	585	787	1646
+4639	PF00121	TIM		Triosephosphate isomerase	Sonnhammer ELL	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.63	0.70	-5.31	56	7470	2012-10-03 05:58:16	2003-04-07 12:59:11	13	10	5835	333	1528	5657	2745	212.10	40	91.49	CHANGED	hhlsuNWKMst...shpcspshhpp.hstthts......slc...lhlsPshshLps.spphlp.......ssplt..lGAQNsphps.p.GAaTGElSsphLpDhGspaVllGHSERRphat...EosphlspKhttulcpGLpsl.lClGEolpp...+csspohplltpQlpshlptlstp....t....sllIAYEPVWAIGT.G+sAosppspcsathIRphltph...stphupplpIlYGGSVsssNspclhppsslDGhLlGuASLcs-sFhsIl	...................................................hlhGNWKhNt...sht..t.stth...hpt...htthhss..............ts-......lsl.ssPhhhLst...s.t..ph.hp.......................s.s.p...lt......luAQ.....Ns............hh......pt......s......GAaTGElS.stMLp-hG.spaVllGHSERRp..h..a...t...............EoD....Eh.....lscKsttAh.pp.GLps.IlClGE.......oL.-p............RE.u.....G..p.......o...-..lltpQlcusltslstp...t.....hp..................plVIA.YEPl.WAIGT.Gc.s.A.o.s.ppApphpt.hlRphltt..........stthup.p..ht.l.YG.GSVpstNst-lhs.....p..s.cl....DGhLlGGASLcsptFhtl.......................................................................	0	528	988	1298
+4640	PF02466	Tim17		Tim17/Tim22/Tim23/Pmp24 family	Mian N, Bateman A	anon	Pfam-B_2241 (release 5.4) & Pfam-B_7792 (Release 8.0)	Family	The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane.  This family includes Tim17, Tim22 and Tim23. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 in [3].	29.70	29.70	29.70	29.70	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.81	0.71	-4.09	129	1856	2009-09-11 16:05:24	2003-04-07 12:59:11	14	27	332	0	1255	1746	12	125.60	21	61.48	CHANGED	ssstchhhss..stuathGslhGuhhsh............................................................hhthh.pssshp...phptslpsstp...s.......hutshushuhlassh........csslpt.h.R.u...+....cDhhNulhAGshoGu.lhut.....ps....Ghpshshu.uhshushuus.....hpth......tthh	.............................................................................................phh.ss.stuhhhGshhGsh.hthh...................................................................................................................th....psss..hp......php.t.s.hps..htp....tu........hu.ts...hushuslaush.............psslpp..h...R..s....................K.........cD.hNulhAGshTGu..lhuh...............ps.......Ghpsh.hh...u.u.hh.h.us.ht.uhhphh....h........................................	0	381	672	999
+4641	PF04821	TIMELESS		Timeless protein	Mifsud W	anon	Pfam-B_3454 (release 7.6)	Family	The timeless gene in Drosophila melanogaster and its homologues in a number of other insects and mammals (including human) are involved in circadian rhythm control [1]. This family includes a related proteins from a number of fungal species.	25.00	25.00	26.50	26.40	24.50	23.50	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.53	0.70	-5.14	23	381	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	261	0	242	392	4	240.50	26	24.27	CHANGED	-sssYtlu-DALtsL+DLh+aL+h.D-php..-ltRsLupuplVpsDLlslLspahp..........cs+ls.AslcLLVsLThPlEh....cs..p....ssst++ph..Lpph..uYKcAhhs...pplhpsllc.hhhsshthshu-RopcDpslIchlLhLlRNILtIssssptptcsD........-cpss+sphl.AhppQslhcLlLhlsSs..tppash.....hlLEIlhhhh+s....sspcLhtsstptotpc....sc-Lpshhc+Epu.p.....+thsp.sssoRHSRFGshhhVp	.................................thYhhts-sL...tsl+Dlh+hl+h.Dppt...sltptlutsp.llpsDLlP.lLhphtp.........................................pppl.h.ss.lclhV.LT..Ph.h...........tt......................s.t...p..pph...pl.ph..sYKc.uhhp............................tphhtslhc.hhh...hl......t..h.s.......h.......tcR......stc-.........phllchlLhLlRNlLtl...st.s.....t..t......phpsc..................................psts....pspll.shp.p.sl.cLLLhlso...s............p....p....p...ash........hllEIlhhlh+s..............ssp..pL...h...t......s.t.........p.t.........s..h......p..c.....................................................t........t.............p..............L.pshh...p.pE.tt..p.....................pthht..p.ssRHucFGs.h...........................................................................	0	90	138	205
+4642	PF05029	TIMELESS_C		Timeless protein C terminal region	Moxon SJ	anon	Pfam-B_5695 (release 7.6)	Family	The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2) [1]. mTim has been shown to be essential for  embryonic development, but does not have substantiated circadian  function[2]. Some family members contain a SANT domain in this region.	29.40	29.40	30.00	29.90	28.30	28.90	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.88	0.70	-5.58	5	232	2009-09-11 11:39:37	2003-04-07 12:59:11	8	10	182	0	164	239	1	364.30	22	35.30	CHANGED	hLHRIAaDLcMsuLLFQLSLFsLFp+lLS-Puussp.....KELcpls...+allRKFlclAssNPKlFVELLFaKssuss+ElspGYsst-stosSKRA.....sWosEEEupLc-Lalsspcl...EspDVV-WILcsLssssRsR+sll++Lh-...hGLtDoscDhhpsKS.......A.ppKupphlLWT........................uDp-l.ELpcLa.......--aRDssDlLs+l.............hcshsu+RS+AclVcK...LLsLGLlo-+RpLp.hKK+RKKpusu.h.sst.p.cs....htE-...E-p...hPcpcsccsccch..utsspsssslcs.pLtppl+pEshphsLhWLQssLhcAA-DcEED.tssQulPLlPLpEcsEEAMENcQFQ+lL+pLGlRsPt...SGpEuaWRIPhhLssspLhhhut.Lut.E..tE.c...EhpschsGEp.u-..Ep...Eccsphhct..pARpRKtGlsoscpc.ths.........cp..+usPKtpph............................................pttptppht........uo-u-pEc-D..hDE......sp.hE.psp-ts..s+p.ttsts-h...sshs.tp..c.s.hssDs-pAD-.usPch+c-KRh...............................tpls.tP.pRR+Lt...llEcDDE	..........................................hhaRlA..achchpshLFplslhplF.ch........lps......t...shs.........+Eh.phs....phll++hhph.h.tp.......p..s.....tlhsEl......LF.K..ts.sss.h.lp.Gatp......s....s.t.pc.t.................hhstt.tptp..p.plh....h.hts.....t.tt.-llphlht.Lss.s.ppR+t.....h......tt.....t.............uh......t..........h.......................................tpt......lhp..................................................................t....thp..lh...........tt.t....p.lt...............................hp......tt.......sp.t..p............hh..s........h..tt...tp.h...t...ttttt....t.............................................................................................................................t................t.......................h..h....tt............p...........s.t..............t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ttt.t.....................................................................................................................................................................	0	52	85	130
+4643	PF00965	TIMP		Tissue inhibitor of metalloproteinase	Bateman A	anon	Pfam-B_1239 (release 3.0)	Family	Members of this family are common in extracellular regions of vertebrate species	21.40	21.40	21.50	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.73	0.71	-4.68	25	416	2012-10-01 21:39:20	2003-04-07 12:59:11	12	6	133	18	187	403	1	147.00	35	78.34	CHANGED	-ACSCs.P.sHPQpsFCsuDl...........VIRAKl....Vucp.hpsss...........thhpYclKphKhaKGhsp.....clphlaTssspul............CGlp.L-sN.tcpYLIoG..+h..DGchal..slCsalp.W-sLohoQ++GLsptYptGCs.C+Is........ChshPCh......lousscCLWTDh.hhptsh.upQucHhsC.lpcssupCuW	..................................................uCo.C......cP.Qp......taCp.uch...........Vl+uK..h...........lupp.stt.ss..............................hhhpYplK.hKhaKG.pp...........clph.....laT.s..sspul............CGl.p..Lcss..........pppYLls.G...ph....sGc.hal..slC.s..al....Wsp..Loh...sQ++....ul.....stpYp...hG...Cp....C.plh.............C.........h..sC.............hpu.scClWhsh....h.........p....h.t.............uhpuphhsC..h.p......s.CsW......................................	1	51	65	110
+4645	PF03549	Tir_receptor_M	Tir_receptor; 	Translocated intimin receptor (Tir) intimin-binding domain	Griffiths-Jones SR, Moxon SJ	anon	PRINTS	Domain	Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation [1]. This family represents the Tir intimin-binding domain (Tir IBD) which is needed to bind intimin and support the predicted topology for Tir, with both N- and C-terminal regions in the mammalian cell cytosol [2]. 	25.00	25.00	121.40	120.10	24.40	21.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.18	0.72	-3.85	3	132	2009-09-10 22:06:29	2003-04-07 12:59:11	9	2	104	8	1	79	0	66.00	83	12.33	CHANGED	PDsAASsAEoATKDQLTQEAFQNPDNQKVNIDENGNAIPSGELKDDVVAQIAEQAKAAGEpARQQA	PDAAAsAsEoAT+DQLTKEAFQNPDNQKVNIDE.GNAIPSG.LKDDVVApItEQAKAAGEpA+QQA	0	0	0	1
+4646	PF04553	Tis11B_N	Tis11B_C;	Tis11B like protein, N terminus	Kerrison ND, Mistry J	anon	DOMO:DM04398;	Family	Members of this family always contain a tandem repeat of CCCH zinc fingers Pfam:PF00642.  Tis11B, Tis11D and their homologues are thought to be regulatory proteins involved in the response to growth factors.  The function of the N terminus is unknown.	19.10	19.10	22.60	21.20	17.90	15.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.80	0.72	-3.88	6	107	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	40	0	47	82	0	114.70	52	31.66	CHANGED	MsTsVlSs.hFDh.-VhsptNKhhsas....s.......PSsus.........sLhDRKsVGTPuhsh.F.RRHSVTsss..............uKF..sQNQhlNs..............LKh-PS.....s.sTuhsNKEN+FRDRSFSEsGER...LL.....ppppPGG	............................MoTTLlSA.haDl..-hLsKs.......p.K.Ls...................s.shs..........shLD+KAVGTP.....suu.........G.......F.RRHSso..p.................sKF..ptNp.hh....uS.....................LK..E.Pu...........sAL..s+E...s+FRDRSFSEsGER...LL.....pQpQ.Gu..........................	1	4	9	19
+4647	PF01108	Tissue_fac		Tissue factor	Finn RD, Bateman A	anon	Prosite	Family	This family is found in metazoa, and is very similar to the fibronectin type III domain.  The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family Pfam:PF00041.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.52	0.72	-4.31	59	788	2012-10-03 16:25:20	2003-04-07 12:59:11	12	11	75	71	325	782	5	101.60	24	26.72	CHANGED	hhhhLlshlLhh..........ssssssslssPp......slphpShNFcplLpWcP.....sts.ssssYoVpap.......htpp..........................pWpsh........Ctphop.ppCDLTsthts....hptsYhsRVpuhsssppSsh	......................................hh.............................stlssP.p......slp.hp.S.....h.N.hc..p.l.L.pWps...........ts....s..tss.sYoVpap............hspp.................................pWpsh.........tC.tphs.p..ppCDlos.thts....hppsY..hsRV+AhhusppS........................................................................................................	0	20	41	128
+4648	PF00265	TK		Thymidine kinase	Finn RD	anon	Prosite	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.29	0.71	-4.71	13	3293	2012-10-05 12:31:08	2003-04-07 12:59:11	13	11	3022	53	635	2063	1299	177.10	38	89.01	CHANGED	GpIplIhGPMFSGKSTELlRplpRYpluph+ClllKashDsRauss.....VhoHDshphsAh....sostLp-lhsthpp..hcllGIDEuQFFs..-llpFs-phANtGKhVIlAuLcusFp+c.FssIhpLlPluEpVsKLpAlC.hCa+-.ASFotRLs......sEsplhlIGGs-pYlSVCRpCY	...........................................................................................pl.hhh.GsM.uGKo...p........pLLpt....s.....hp.a..p.............t.....s.hp..s.l....l...h.pssl.D.s...R..hutu................pVs..SR..hGhptpAh....................ss.s...h...h....p....c....l.....h..p.....p......h.........p..p.......p....h.....c...slhlDEsQF.....h.....s...pp.......l.h.p.l.s.c.l.l.s...p...h.s.l..sV..lsa......GLcsDF.+s-hFt.u.othL.L.s..h..A.D..c..ls..c..l..+..sI..C.....h..CG.....+..c.....AohshRlsps...............shh-ucQ.....l.....h...I...G.......G.....sE.........p......YhslCR+Ha............................................................	1	226	409	532
+4649	PF00693	Herpes_TK	TK_herpes; 	Thymidine kinase from herpesvirus	Bateman A	anon	Pfam-B_186 (release 2.1)	Family	\N	25.00	25.00	26.90	34.60	22.40	19.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.94	0.70	-5.24	14	508	2012-10-05 12:31:08	2003-04-07 12:59:11	13	2	87	61	0	548	0	249.80	52	70.99	CHANGED	GsaGlGKTTTucslsstssst.s.hLahPEPMsYWRshFs.oDslsuIhssQsR+ppGplust........cAshlsAphQupassPYhlhattlsshh...uuphs.s....s.P....slTLlhDRHPlAuslCaPhARYllG-hohpsLluhlAslP.EsPGsNLVVsoLs..sEHhcRLtsRuRPGEplDhshlsALRNVYuhLsNTspaLpsGss.....WRcsWspLshhssshhtphsp.sshstp...t.PsLpDTLFAhhKs.ELhsspGs.LhslHAWsLDuLss+LpsLpVFslDls	.....GPHGhGKTTTophLsuhuu.R..DcIVYVPEPMTYWpVLGA..SETIuNIYsTQHRLDpGEISAG........DAAVVMTSAQITMuhPYAlTDAVLAPHI...GGEusuS..pAPsP...uLTLlFDRHPIAALLCYPAARYLhGuMTspAlLuhluhIPss..hPGTNIVLusLP.EccHlcRLu+RpRPG.E.+.lDL..uMLsAlRpVYthLsNTl+YLQtGup......WR-DWGpLsu..sAh..phscsps....s...t.PcIt-TLFslF+sPELhsssG-.LhplaAWsLDsLAp+LpshplFhLDh.c....................................................................................................	0	0	0	0
+4650	PF03219	TLC		TLC ATP/ADP transporter	Mifsud W	anon	Pfam-B_2261 (release 6.5)	Family	\N	19.30	19.30	20.20	19.30	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.75	0.70	-6.02	27	560	2012-10-03 03:33:39	2003-04-07 12:59:11	9	8	194	0	186	483	158	424.20	32	84.80	CHANGED	tsptppthuc...........h+thhWPlcthElpKhlPhslhhFhILFNYslLRshKDolVlTuh...GAElIsFLKlWsllPuAllhhllYsKLuNhhopEplFYhllssFLsFFhlFuallYPhp-hlHPss.s.phhshl.sshphhlshhtpWoaulFYlhuELWuolVloLLFWtFANpITplpEAKRFYsLaGlhuNhuLlluGphlhahus.........hhpths.sl...csathplphlhslllluGllhlhlahhls+.V.........Lsssph...........sshppt.+KpKsKholt-ShphlhpS+YlhhIAlLVluYGlsINLVEssWKupl+plYPss.......s-YssFMGphsshTGlsollhh.hlGusllR+hGWthuAllTPlllllTGlhFFuhllFpcpls.hhush.GhsPLhlAVhlGuhQNlhSKusKYSLFDsTKEMAYIPLDpE.KsKGKAAlDVlGu+lGKSGGulIQphlhllh...uohss.sPaluslhllllllWlhuVppLs+pa	...............................................................................................................................................................hpthhhslp...hEhpKhlPhshhhFhIhhN.shlRshKDslllst....uAEhlsFlKhahshP.u.hlhhll..YsKLs.s.h...hshct.lFahlhs.FlhFFslFuhll.a.P..t.....ch....hH.......ps...h..............p..............h..........h..............st...ht.h....hl...h...l...ht.pWoas..laYlhuELWsslhhslLF...WtFANpITpscEAKRFYslhulhuNhullhuG.hlhhhup........................hh..h...ts...ss.th.l....h..h.slllhsuh.lhhhha.....h.hl.s+..l............................lsp.h..................thhpt.cpp+.Kh.uhh...-Sh.phlh....pS+YlhhlAlll.lsYGls.......I.N....L.........VEs....sWK....upl....+....p..ha.P.ss................ppY...ssa..h.Gpa....hh..s.Gl...ss...l................hhh...hl.....u..s...sl...l.RphGWhhuAhlT...Pl.hh.h.....l..T..G......h.h.FF.....u.hlh..F....t......p...h.......s.....h....h.....ss.h.................h..h.......sP.Lh......l..A.lh....l...G....ul..Q..NllS.....KusKYoLFDsoKEMAYIPLDp-hKs.KGKAAlDVlus+lGK..SuGullQphhhh.lh....uohssh..sshlhhh.hhllhhhWlhusttLsppa......................................................................................................	1	91	121	149
+4651	PF05017	TMP		TMP repeat	Bateman A	anon	Pfam-B_1012 (release 7.6)	Repeat	This short repeat consists of the motif WXXh where X can be any residue and h is a hydrophobic residue. The repeat is name TMP after its occurrence in the  tape measure protein (TMP). Tape measure protein is a component of phage tail and probably forms a beta-helix. Truncated forms of TMP lead to shortened tail fibres [1]. This repeat is also found in non-phage proteins where it may play a structural role.	15.00	2.90	15.00	2.90	14.90	2.80	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.78	-6.01	0.78	-6.19	0.78	-2.30	95	345	2009-09-16 13:22:24	2003-04-07 12:59:11	9	15	44	0	65	324	23	10.90	35	10.45	CHANGED	WssIpshhssh	WsuI+shhos.....	0	54	56	56
+4652	PF02581	TMP-TENI		Thiamine monophosphate synthase/TENI	Mian N, Bateman A, Griffiths-Jones SR	anon	COGs	Family	Thiamine monophosphate synthase (TMP) (EC:2.5.1.3) catalyses the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine  phosphate [1]. This Pfam family also includes the regulatory protein TENI (Swiss:P25053).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.00	0.71	-5.16	89	5722	2012-10-03 05:58:16	2003-04-07 12:59:11	12	31	3919	62	1431	4669	2676	177.90	29	71.70	CHANGED	lYhlTsst.t........tp...hhchlcpAlpu..........G.lshlQlRpK.....p....hss...pphhphApplttlsc..ph..ss.hllND..clclAht.....lsA.......DGVHlGQ...cDh.ssspsRplhusshllGlSspshp-...stpAt...ptus..DYluhGslasTsTKtss..pshGlptl.pphtpthp..........l....PllAIGGIshpslsplh........psGssulAVloAl	.............................................................................................................................ahlss................tt...hhphl..cp.s.l..pu.....................G...ls..hlQ..lRpK..................................s......h.s.s......p..c.hh.p......h......stp......l.ttl.s.c........pa..........ss...ll..lN......D.....c.h....cl..Aht..........h.s.A...........c..G....V..Hl..GQ................c.D...h.........s.........s......s.......p......h....+......p....l....h...........s.......s................s.....h.......l.......l.G.lS..s.+..shp-.....htpAt..................t.t.ss......DY.....lu..l......G....s.l.a.s........T.s..o.......Kp...s........s...ss..hG......l....p..t...l...p.ph.t.p.t.hs..............................l..PlVAIGG..I..s..h..p..s.h..s.p.lh..............t.sG...s...sulAVlsul.............................................................................................	0	467	957	1229
+4653	PF00721	TMV_coat		Virus coat protein (TMV like)	Bateman A	anon	Pfam-B_746 (release 2.1)	Domain	This family contains coat proteins from tobamoviruses, hordeiviruses, Tobraviruses, Furoviruses and Potyviruses.	23.00	23.00	23.50	23.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.92	0.71	-4.29	47	557	2009-09-11 05:07:10	2003-04-07 12:59:11	16	2	125	27	6	518	0	140.10	31	54.13	CHANGED	sYs...hss...pphhhhsssaschpshhshlpshpuspapspsuRstltstlusl.h......psssshspRFPss.s......h....hlhhtssslt.llssLhsuhc..ocsRhhEhppss....ssssups.s.....ssptssD..ush.sl+ssltplhstLsp.t....sshasp.....spFE	........................Ysh..hss...pphhhhsssascs.plhshhpsuhusphps...ppuRsslppphusl.h......pshsshssRFPss.s.........h....hVhhhssslcsllssLhsuhD..T+NRhhEscs.t.....sPssuEs.s.....sTpts-D......uol.Al+sslspLhstLhp.t.....pshaspspFE....................................	0	1	1	4
+4654	PF00229	TNF		TNF(Tumour Necrosis Factor) family 	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.70	0.71	-4.57	52	1178	2012-10-01 20:41:10	2003-04-07 12:59:11	13	10	195	271	481	1150	10	120.10	23	49.88	CHANGED	LpWppst...tshhtsGhphpssp..LllspsGlYalYoQlhFp........tsstt.................h.lshtlhhhssph....sp.hsLlpuhc.sssptts..........hhpslYhGulapLppGDclhlp..ss..p.shlchs..sspoaFGsatl	............................W.tt......h.h...p..shph.p..ssp....Lhl.psGlYalYuQVhFp........ts.tt............................t.h.lsttlhphssth......sp.ph...sL..hp.shp..ss..s.pt..ts...............hhpoh..ahG...G.lhpL.c.pGDcl.lp...ls......p.phlpht....tstoaFGhhhl...............................................	0	63	98	204
+4655	PF00020	TNFR_c6		TNFR/NGFR cysteine-rich region	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.07	0.72	-3.89	37	2327	2009-01-15 18:05:59	2003-04-07 12:59:11	13	54	156	88	889	2043	25	38.90	30	15.97	CHANGED	Cpps..pYpc...ps...t.C..C.shCps..GphhhpsCst.spsT.hC	...................C.ps..pY...ps.......sh....tpCh.C..spCss....uph.hh..psCos...spso..hC..........	0	184	248	442
+4656	PF01107	MP	Tobamo_MP; 	Viral movement protein (MP)	Finn RD, Bateman A	anon	Pfam-B_815 (release 3.0) & Pfam-B_1906 (release 4.1)	Family	This family includes a variety of movement proteins (MP)s. The MP is necessary for the initial cell-to-cell movement during the early stages of a viral infection.  This movement is active, and it is known that the MP interacts with the plasmodesmata and possesses the ability to bind to RNA to achieve its role [1]. This family also includes consists of virus movement proteins from the caulimovirus family. It has been suggested in cauliflower mosaic virus that these proteins mediated viral movement by modifying plasmodesmata and forming tubules in the channel that can accommodate the virus particles [2] and references therein. The family contains a conserved DXR motif that is probably functionally important.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.83	0.71	-4.92	18	493	2009-01-15 18:05:59	2003-04-07 12:59:11	13	31	165	0	22	530	0	167.20	20	27.73	CHANGED	hpplchs-...hlsLsps-phhs..shhpthKpshh++schlhsl............ppsculsplsLlsps.hp..........ctpchsal+luulhlslcsph.cshcsslplsLlDsRh.pstc-.uhlusacsshshtchtFplhPpYulShpD.slc+shplhsphcsls.MccGspPholcassshtloNSphslsh+phhssl	...............................................................................................................h..................p.h.............p.h......pp..hhhs..................tpspth..lsllpt........................ptpphsa..lHlusl.lshchh.h...p......sh.ssshtlsLhDsR.......h..tp...hc-...u....hlushpsshsps.p.hhh.p.h.hPsaslshpD.shppshplhlphcshp.hptGt..psholpht.hh.hhhs...s.h...........h.......................................	0	0	15	18
+4657	PF04052	TolB_N		TolB amino-terminal domain	Bateman A	anon	Bateman A	Domain	TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.14	0.72	-3.96	174	1688	2012-10-01 20:48:06	2003-04-07 12:59:11	8	19	1656	15	404	1275	1658	103.20	37	23.83	CHANGED	lpIcIop.GsspshPIAlssFt...spsss........thspplupllssDLppSGhFpslstsshhppstp....sspspassWpslsupullsGpls.ttsss...hplpacLaDlhp..sppl	.........................................lcI.Isp.GsssshP.IuVl.PFp........htuss............hPpcluslluuDL.cp.S.GpFsP.lspuphsppsss..........spplphss.W.p.u..l....G.h-A..lVsGpVs...s..scG..papVsapLhDs.tt..............................	0	106	226	315
+4658	PF03349	Toluene_X		Outer membrane protein transport protein (OMPP1/FadL/TodX)	Mifsud W	anon	Pfam-B_3708 (release 6.5)	Family	This family includes TodX from Pseudomonas putida F1 Swiss:Q51971 and TbuX from Ralstonia pickettii PKO1 Swiss:Q9RBW8. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD Swiss:O33458. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.48	0.70	-6.11	22	2710	2012-10-03 17:14:37	2003-04-07 12:59:11	11	6	1716	33	577	2172	277	395.70	23	92.57	CHANGED	sshssstshAuuh.hst.usuul.uRAhuGpuuhtc.ssushhpNPAshshhcp..sp..hphGhshlssc.lchpssssstph......................tstsssssshhlPphthlh....s-pauaGhulhsshGluocass.sahups..............huspocLtsls.lshusuY+Vs...cclSlGuulshsaspsplpp.......hhs...........................shsshsss...s.sssshhthts-shuhGaplGhhachsc.ssplGhsYpucs+h.chcGphshshssuhhs.h........................shsGplpl...plPsthpluhhHph.s-paslthshphstWSshpcl.........thtts.....tst..hshshs.sa+DshthulGssYphssphTlRuGhsYcpsshsspp.tsshlPsscppa.hShGhoYshs...ptslDhuauahhtccsshsp.s................sshshp.spssshlhulshshpF	........................................................................................................................................................................................s....ss.s.uu.uat.l.tp.......os.s....uh..up..A.hu.Gtus.h.s.s.s.A.u.sh...h..NPAhhshhcp.....sp.......hssuhs..h........l..pss.......h..p...h..p..s..s..s...s..s.t..t.t.................................................................................................psts..h..ss.s..t...h...l...P..s.h......a..h.s..h...l..........s-.p.......h...s..h.G.h.u..h.h..s...s..a.G..h.s.o...-....a...s..s.....s..hsu..t.............................................................................................hu.s.p..s..sl..p...s......hs......l....s.....sh..u...Y.....+...l..s.........p.phShGhGhsh..h.a..s.p.up.lpp............h.s..............................................................................................s..shs......sss...st.h.....s....p...h...p..us....s.hu.h..G..a..s..hGh..h.a..c..l........s...c....s......t..R..h....GlsY+S....clc....h...ch.c...G.s.hs....t..h.......s..h...t.................................................................................s.s.u..p.h....s.l.......slP..phhplus....hpp..l....ssp.h.......sl..phshpaTsWS..p..appl..................................ps.p.s.......................t....sh....h.p..t.p.t.......ta.c.D.sa....phu.lGs.....s..Y.......p.h...........s...c.......p.h...........s..hR..s........Gl..........ua..........Dpo..........shs..........s............p...............p.....t...............s...............h...............p.............l............P........c..............s....-......R.h.........h.............hohG....ss..Y..p.hs........ts....h....slD......h.uh..s.a.h.h.t.p.p.s..p.h.s.p.................................ssh..php...ps.p..s....hhuhphshtF...........................................................................................	0	153	342	479
+4659	PF04281	Tom22		Mitochondrial import receptor subunit Tom22 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The mitochondrial protein translocase family, which is responsible for movement of nuclear encoded pre-proteins into mitochondria, is very complex with at least 19 components. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins.  This family represents the Tom22 proteins [1].  The N terminal region of Tom22 has been shown to have chaperone-like activity, and the C terminal region faces the intermembrane face [2].	28.70	28.70	28.90	28.70	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.90	0.71	-4.64	30	269	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	232	0	191	247	0	117.40	30	76.41	CHANGED	M.VcLTEVcDEshp........t..hsptpstttss.s-s--.o-s-SDh.sD..-.D........-sETlh-RlsALKDIlPPppRppIusthusssohh+oshshuGphlWsloTSALLLGVPhALAlhsEpQllpMEK.EhshQcsAs-.lLAP	..............................................................................................t.pcs-p-h.pp...-..D.p.........cETlhERlhuLp-hhPspsRpthusshs...tssshspshhpaoupuhWlhoTSuhlLslPlshth.....t...EpphhpMEp.p.p.hppt........t.........................	0	55	92	147
+4660	PF03220	Tombus_P19		Tombusvirus P19 core protein	Mifsud W	anon	Pfam-B_2714 (release 6.5)	Family	\N	25.00	25.00	26.80	299.80	21.40	15.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.19	0.71	-4.91	4	59	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	3	0	44	0	172.00	83	99.71	CHANGED	MERAIQGsDAtcQAsuERWDGGsGuohoPFQLPDESPohcEWRLHpsEpsscpDpPLGFKESWuFGKVVFKRYhRYDhpEsSLHRsLGSWpGDoVNhAASRFhGVsQlGCTYSIRhRGlSlTLSGGSRTLQRLlEMAIRhKho.LQLsssEVEusVSRGCPEusps...cESE	MERAIQGNDAREQANSERWDGGSGGoTSPFKLPDESPSWTEWRLHNDETNSNQDNPLGFKESWGFGKVVFKRYLRYDtTEASLHRVLGSWTGDSVNYAASRFFGhsQIGCTYSIRFRGVSlTlSGGSRTLQHLCEMAIRoKQELLQLTPlEVESNVSRGCPEGscsF.ccE..p.....	0	0	0	0
+4661	PF03544	TonB_C	TonB;	Gram-negative bacterial TonB protein C-terminal	Griffiths-Jones SR	anon	PRINTS	Domain	The TonB_C domain is the well-characterised C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane [1]. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.39	0.72	-3.78	109	5753	2012-10-03 21:09:15	2003-04-07 12:59:11	9	80	2084	10	1601	5569	1848	76.60	24	29.38	CHANGED	ht.pYPppApppsh..pGpVhlphslsssGplps.hpllpuss..t.hL-cuAl.cslcp...hpatPthts.sp...slshph...slpFp...L	..........................h...pYP..tt.At.p.t.th....pG...p...V..h..l..phs.l.s..t.s.G.......p..l..p..........s....l........p.......ll....p............u...s..................s..........s...hlDc..tAl.c.slcp.....h+.....ap.Pshts..Gp......sl.p.hhh....sltFp..................................................	0	574	1099	1396
+4662	PF00593	TonB_dep_Rec	TonB_boxC; 	TonB dependent receptor	Bateman A, Yeats C	anon	Yeats C	Family	This model now only covers the conserved part of the barrel structure.	16.60	16.60	16.60	16.60	16.50	16.50	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.66	0.70	-4.48	666	34093	2012-10-03 17:14:37	2003-04-07 12:59:11	19	67	2349	66	8506	31731	11867	284.70	12	36.18	CHANGED	sPphul......aphss..............shslhu..saupuacssshsphh..............................................................................................................hssssLcPEpupshElGhchphts..........hphshsh.aptchcshlstsssssshsstsstttttttttttstttthththhtththhhh............................................................................................................................................................tttssttststtsthhtttsthhtththtttthtththshshthsspttsssssshph..suashh-ht.ssY.phspt................hplphs...lpN...Lh..........s.cpYhthhs.t.........................hhh.u............................................sR.shhhslshp	......................................................................................................................................................................................................................................................................................................................................................................................................................................sphuh......ap.hsp..................................phplhs...ua..up..s..h..p...s.....s..s..h..tp..hh....................................................................................................................................................................................................h...ssssL....c....s...E....p.....u.....p...s.....h...-lG...h...c..h..p.hh..s...............................hphs.......hs..h..a.p.p..c.....h.....p.....s....h........l......h.......t......s.......s.......s.....s...........s.......s.................s.....h.......t......s.......t.......t.........t.........t.....t....s...t...h.......t......t.....t..t...h...t.........h..h..h..h...t.h..h..h..t..t...t...t...t..h...h..h.....................................................................................................................................................................................................................................................t.t.t.t..t...t.t..t..t..t..t....h....t....h......h....t....h...h...t.....h....h.....t.........h.....t.....h.....t............t..........h...t........t......h....t...........h..........t....h........t.......h...........t......h......t.........s........t.........t...........h....s........s...........s......t........t.....h....h...p..h................s.......s........h.........t....l....h.s.lt.....hs..Y...phspp..................................................hpl..t..hs.....spN.........Lh.....................s...p..ph.h.t...ht.t................................................h.s.................................................s..R..s..hhhshph....................................................................................................................................................................................................................	6	2644	5782	7351
+4663	PF01131	Topoisom_bac		DNA topoisomerase	Finn RD, Bateman A	anon	Pfam-B_505 (release 3.0)	Family	This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax  negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.	23.10	23.10	23.20	23.20	22.70	23.00	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.60	0.70	-5.65	126	9972	2009-01-15 18:05:59	2003-04-07 12:59:11	15	124	5053	35	2152	8171	4882	388.60	29	56.06	CHANGED	chshsLspAthsRphhDhllGhslSp.hh....s..........t.....tsl.SsGRVQoPsLthlV-R-cEIcsFh....sp...a..aplp...sp.............h....................ttthh..............................ttpptphhscp..pApphhppl.p.............t......lp..plcpccc..pp.ssP.PashssLQpcAspphu.houpcshplAQpLYE........p.G....lIT..YPRTDSphls.ps......s.hpthhphlpp..t......hhs.....h.th...tp..........stp...sAHcAIhPTtshs.......sphs..........cctp.........lYcLIhcRalAs......hhssshhppsplpl...t........tt.........FpspGppllp..tGaptl...h.........ttpppp................lP...lpp...Gch...........l.h..tp.p...h.tcpTpPP.spaoEuoLlptM-pt.........................GlGpsuThAsIIppLh...cRtYlppt....p.pt...lhPTchGhtlh.chL.......p....h...p..lssschTuphEppL-pItcGchs.hpphlp	.....................................................................................................................................p...hsLssAt.ARphhDhllG..hs.h.S.hl......p..................................................p..ptsL..Ss..GRVQossLt.lllcR-..cEIcsFh......scp.....a.....aplpup........h..................pttttp..................................................................hptpphch.h..s.cp......psp..t..l..h.....p.t..lps......tt................hpVp.pl.pp.Ktp..............pp..tsPhPash..o.oLQpcAup.+hs..au......s....ccThpl.......AQ.pLYE............p.t.....hI..........T..Y.RTDSph......l...spp......u.hp.t.shph.l..t..p..p..h.st....................pahs....h....p....h..h..t..t..t.......................pssp........pAH.cAIhP...T.tth................tphs...................................................pppt..plYpLIhp+alAs..h.s.s.uhhcpsslpl.......ph...................................st.hp....F..p..u..p..G.ph.lh...t..Gahpl.............h...........tttppppt.t.........................................................LPt..lppG-t.............................................lph......tp..hp.......pp.+h.TpPP.s+aoEAoLlp...t...h.Eph........................................GlG........p.......suTh......AslIpsl..........c.R....t........Y........lph.............p.+p.........lhsTphGhhlhphl.......p.............................p...........lhs.......p......hTAp....h.....EppLcpI.tp...Gphphpphl............................................................	0	747	1386	1825
+4664	PF02919	Topoisom_I_N	Topoisomer_I_N; 	Eukaryotic DNA topoisomerase I, DNA binding fragment	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1377 (release 3.0)	Family	Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2]. This family may be more than one structural domain.	25.00	25.00	25.50	26.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.37	0.70	-5.05	47	487	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	324	17	282	471	28	203.10	51	28.20	CHANGED	hKWpoLcHNGVlFPP.Yc.LPcsVKhhY-GcslcLsscsEEVAsFaAshL-o-.aspp.sFp+NFFpDF+chlscpttt............IcchcKCDFophapaappp+....EpKKshocEEKK........tlKtE+-c.h-c.YtaCllDG+.+E+VGNFRlEPPGLFRGRGpHPKpGpLK+RlhPE.DlsINluK-u.lPpPP....sGH.+WpElpHDNoVTWLAhWpE.NIssp.hKYVhL	................hKWppLEHpGslFsPsYc.LPcsV+hhY-GcslcLssc.sEEVAoFautM.L...-.......p.....-......Y....spcthFpcNFFpDa+.c.hsppptt...................hIpshpKCDFs.hapaaptpp.......E..t+.......K..sho+E.....EKp.......................tlKpEp-c.hpppYtaClhDG+.+E+lGNF+lEPPGLFRGR.G-HPKh.....GhLK+RlhPE.DlsINhu.....K...........-utlPpPP...................sGH.+WKEV+HDNpVTWLA.WpE.NIpss.hKYlhL..................................	0	94	151	229
+4665	PF01028	Topoisom_I	Topoisomerase_I; 	Eukaryotic DNA topoisomerase I, catalytic core	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1377 (release 3.0)	Domain	Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2].	20.90	20.90	20.90	20.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.56	0.70	-5.26	134	1273	2012-10-02 14:09:14	2003-04-07 12:59:11	15	15	1066	23	472	1266	171	214.00	37	46.11	CHANGED	tDucsRpQYhYt...a.t.+-tpKac+hhchtptlsclR.cplpc-L..........psthsc.c+.lAsslhLlD................phhlRlGs-cYsc-st.ohGhsTLRscHlp.lps.............................................................................s.tlpFcFhGKsulcaphplc....Dpplh+slpth...........p...chPGpcLF.............cpls................................osclNpaL+chh..........ts.........hTAKsFRTasuolthhpt.....Ltph...................................................................................................t.....shsptppthstus+pVAthlspT.ul.s+ppYlpspllp..thtt..t.h...tthtph	....................................................................sph+tp...........ps.tKapphhthtphlstlR.tthptph.................ttt..t....p..hAshhhhl-.........thhlRsGspp.tpcpt....o...hGhsoLRscHlp.lpt.............................................................................p.slhFDFlGKDu.I+ahscVt...........h-.....c...+V..aKsLphhh............cs...KtPG--LF.............c+Ls................................oshlNcaLp.clM......ps...................lTAKsFRTYsAS.h.Thtpp.....Lpchs..............................................................................................................................st..s..shsp+hhshscAs+tVAhlssH.p+uV.s+.s..phhphphLptthpt..............s.................................................................................................................................................	0	137	260	379
+4666	PF01751	Toprim	Primase;	Toprim domain	Bashton M, Bateman A	anon	Pfam-B_500 (release 4.2)	Family	This is a conserved region from DNA primase. This corresponds to  the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1]. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely  abolish DnaG type primase activity [1]. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division [2]. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases [4]. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-4.03	136	24868	2012-10-01 21:47:57	2003-04-07 12:59:11	17	150	8181	82	4223	22716	8361	107.80	31	17.30	CHANGED	plhlVEusscstslpphhs..................................htlhsshGphhsh.p...........................................................lptltphh.............................................phpclllssDsDp.....-Gpplshplh.phhtthh..........tchhhspl	............................................................................................................................................................................................pLhlVEGcS.s.u.soh...cpuhs..............................................pp.psllsh....+G+..l.l.N.lpc.sp...hsc........................................................................................................................................................hhpspplpsl.hpsh...........................................................................hc..h..c..cl..llhoD..sDh.............-Gt.tIthhlh..phhht...h............thlhht..................................................................	0	1416	2671	3539
+4667	PF01533	Tospo_nucleocap		Tospovirus nucleocapsid protein	Bateman A	anon	Pfam-B_950 (release 4.0)	Family	The tospovirus genome consists of three linear ssRNA segments, denoted L, M and S complexed with the nucleocapsid protein. The S RNA encodes the nucleocapsid protein and another non-structural protein [1].	19.80	19.80	22.00	60.50	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.54	0.70	-5.14	11	1122	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	38	0	0	714	0	238.40	61	94.92	CHANGED	MSps+.lTccpIpcLLsuuct-VElEp-psphuFNFKsFapsNps.lc.hohssslohLKsRppIhtssKpucas.FsshsIlto...SspVus..sDaTF+RL-uhIRsKhlptl..ocNscsppchhsKlhshPLVpAYGLp..uhhDtsulRlhlhlGGsLPLlASlcohtshuhsLAhYQssK+EpLGI..ppFsThEQLsKVspVhpupuhphscs.cchhcphscILssssPsspGuh..uhc+YsEplpthtss.F	....MSpVK..LTKEsIVsLLTQG+.DlEFEEDQNhlAFNFKTFCLsNLDpIK.KMSlhSCLTFLKNRQSIMKVIKQSDFT.FGKITIKKT...SDRlGA..sDMTFRRLDSLIRVRLVEE......TsNuEsLsoIKoKIASHPLlQAYGL...PLsDAKSVRLAIMLGGSLPLIASVDSFEMISlVLAIYQDAKa+-LGID.KKaDT+EALGKVCTVLKSKuFEMsEDplKKuKEYAsILSuSNPssKGSl..uh-+YsEplshh.phF...	0	0	0	0
+4668	PF00087	Toxin_1	toxin; toxin_1; 	Snake toxin	Eddy SR	anon	Overington	Domain	A family of venomous neurotoxins and cytotoxins. Structure is small, disulfide-rich, nearly all beta sheet.	20.70	20.70	20.70	20.80	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.12	0.72	-3.60	48	594	2012-10-03 01:43:02	2003-04-07 12:59:11	16	1	92	141	6	666	0	60.80	38	79.57	CHANGED	hpCapp.s....socTCP.tGpNlCY.K......pa.pc...p..+Ghh.l-RGCusoCPpscs.hhplpCC.sT.DcCN	..................................pChpp.t...s.sscoCs.sGcshCYp.K......tapc..........p.ps.hh..lcRGCu.s..sC..Ppscs.....thpl.......p.CCsT.DcCN......	1	3	3	3
+4669	PF00451	Toxin_2	toxin_2; 	Scorpion short toxin, BmKK2	Finn RD	anon	Prosite	Domain	Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity [1].	25.10	25.10	25.30	25.40	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.28	0.72	-3.86	48	130	2012-10-01 23:31:40	2003-04-07 12:59:11	14	1	40	50	1	165	0	31.00	44	65.14	CHANGED	lcCssopcCht.sC+chhGpttG.KChNsKC+CY	....l+Csuopp.Chp.sC+cthGhttG.KChNs+C+Ca.	0	0	0	0
+4670	PF00537	Toxin_3	toxin_3; 	Scorpion toxin-like domain 	Bateman A, Moxon SJ, Finn RD	anon	Pfam-B_8170 (release 8.0)	Domain	This family contains both neurotoxins and plant defensins.  The mustard trypsin inhibitor, MTI-2, is plant defensin. It is a potent inhibitor of trypsin with no activity towards chymotrypsin. MTI-2 is toxic for Lepidopteran insects, but has low activity against aphids [1].  Brazzein is plant defensin-like protein. It is pH-stable, heat-stable and intensely sweet protein [2]. The scorpion toxin (a neurotoxin) binds to sodium channels and inhibits the activation mechanisms of the channels, thereby blocking neuronal transmission. Scorpion toxins bind to sodium channels and inhibit the activation mechanisms of the channels, thereby blocking neuronal transmission	21.50	21.50	21.60	22.00	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.76	0.72	-4.09	33	487	2012-10-01 23:31:40	2003-04-07 12:59:11	13	1	55	78	15	598	0	53.00	38	69.05	CHANGED	+D.....uY..Is.pscNCsYpC.....h.h..ssaCsshC+c.pGAcuG.aChahu...hs.ACaChsLPDss	................+-GY....ls..pspsCthpC........hh...ssaCs.p.C........cp..pGup.s....G.YChhhu..........tCaC.sLPDp.......	0	7	7	7
+4671	PF00706	Toxin_4	toxin_4; 	Anenome neurotoxin	Bateman A	anon	Pfam-B_589 (release 2.1)	Domain	\N	20.90	20.90	21.80	21.60	18.00	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.40	0.72	-3.75	7	75	2012-10-01 20:50:19	2003-04-07 12:59:11	12	1	27	7	9	95	0	43.60	56	70.66	CHANGED	sChCDsDGPslRssshoGTl...huuC...suGWcpCtuhhssIu.CC	.sChCDSDGPslRGsoLSGhl..Wl.......uuC...PSGWHpCpuptshlu.CC	0	9	9	9
+4672	PF02079	TP1		Nuclear transition protein 1	Mian N, Bateman A	anon	IPR001319	Family	\N	25.00	25.00	68.00	67.90	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.79	0.72	-4.20	3	42	2009-09-11 05:49:06	2003-04-07 12:59:11	11	1	36	0	15	30	0	52.00	85	95.33	CHANGED	STSRKLKSHGMRRGKNRoPHKGVKRGGSKRKYRKSSLKSRKRGDDANRNYRSHL	.STSRKLKSHGMRRGKNRoPHKGVKRGGSKRKYRKuSLKSRKRuDDANRNaRSHL.....	0	1	1	2
+4673	PF01254	TP2		Nuclear transition protein 2	Finn RD	anon	Prosite	Family	\N	25.00	25.00	51.80	51.70	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.11	0.71	-3.83	4	40	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	25	0	12	46	0	124.20	61	99.72	CHANGED	MDTKTQSLPsTHsQPHSNSpPQSHssppCuCS+HCQopSQS.....pssRSpSSSppPtuHR......S.sG+QSQSPuPSPPs+++K+sMHSHpsPSRPso+pCSpsKNRKNLEGKlpKRKtlKRppQVYKsKRRSSGRKYN	..MDTKTpSLPlTHTQ.HSNSpPQS+T...st.CsCo+HCQohSQSCppupps......SpSRSSSQSPsuHp........SsoGpQS..QSPssSPPPK+HK+TMpSHHuPsRPThh+sSCPKNRKNLEGKlpK+KhsKRhQQVYKTK+RSSG........	0	1	1	1
+4674	PF04406	TP6A_N		Type IIB DNA topoisomerase	Waterfield DI, Finn RD	anon	COG1697	Domain	Type II DNA topoisomerases are ubiquitous enzymes that catalyse the ATP-dependent transport of one DNA duplex through a second DNA segment via a transient double-strand break.  Type II DNA topoisomerases are now subdivided into two sub-families, type IIA and IIB DNA topoisomerases.  TP6A_N is present in type IIB topoisomerase and is thought to be involved in DNA binding owing to its sequence similarity to E. coli catabolite activator protein (CAP) [1]. 	20.50	20.50	20.50	20.80	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.02	0.72	-4.31	65	534	2009-09-14 12:29:41	2003-04-07 12:59:11	9	9	417	7	349	531	120	69.40	27	18.33	CHANGED	shp...psp+.....hsphhhllphl.pctlppsphs.ThR-lYYpspp................hF.ss........QspS-pll-Dlph.hhsl..REphplh	..........................t..tpsp+hsthlhllphl..hchlp.p..sphs.Th.....R-lYYpshp.................hF.ps........Q....sps.DpllcDlsh.hl...tl..sRpsLpl..............................	0	105	197	287
+4675	PF00590	TP_methylase		Tetrapyrrole (Corrin/Porphyrin) Methylases	Bateman A	anon	MRC-LMB Genome group	Domain	This family uses S-AdoMet in the methylation of diverse substrates.  This family includes a related group of bacterial proteins of unknown function, including Swiss:P45528.\	  This family includes the methylase Dipthine synthase.	27.30	27.30	27.30	27.40	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.45	0.70	-4.63	171	17348	2009-09-13 05:43:58	2003-04-07 12:59:11	15	82	4907	229	4809	13595	4640	206.00	21	64.04	CHANGED	plhllGhGsGs..s.-hlThcAhchlp.pA-ll.....h....sss....................p......shphl..h....................................t........hphhpts......................hpphtchl..htthppstt..Vshls.sGDPhla..uhsthlh.t..hlttt...h....hc..llPGlSohpsssuthuhshs.psthhphhh...............s.t..ttthhpph.t...........sslllh........hsst..t.......htplhphL...........hpt...........p.tlhlscp.....huhs.s.Ep..lh.psslppls	.............................................................................................................................................................................lhlVGsGs.Gs........p...h...lTh..+uh...........ch...Lp...pA....Dll.....................hhcs.............h......ssphl.hphh......................................................................ttt............ht.hh.phs........................................................................tpch.s.p...h..h........l..p..t.h.p.pG..pp......Vshls..uGDPhla.......uhutc.hl.p...........th..t....p...............t...s...lt....................hp......l..l..PGloushuu..sut.....s.....Gl....s.hs.....t.h...h.pslh....................................thtt..p..pt.p..hp.t.h.ttt.......................t.pol..l.hh...................................husp...p......................lsplh.p.tL......................................................hpt...........s.pp.lsl..s.cc........ho.ps..p.pp..lh.pssltph................................................................................................................................	0	1545	3155	4100
+4676	PF04201	TPD52		Tumour protein D52 family	Bateman A	anon	Pfam-B_2632 (release 7.3)	Family	The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family [1]. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other [1].	25.00	25.00	29.60	28.80	24.90	23.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.06	0.71	-4.51	4	406	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	101	0	173	372	1	162.90	44	79.83	CHANGED	uLlhspshsEsstshssohsuo..sLSEtEp-EL+sELsKlEEEIpTL+QVLAAKEKHhuElKRKLGhsshsEL+QNluKSW+DVpsTsAYh.........tQKsosAhuuVGosIs+KhsD..................h+NSsTFKSFEpKVto....lKo+VuGs+.sGus.hsclluuusssSAp	...............................................................h..s....t....p.s......LoE.pE..p....E....E....L+....t....E....LsK.V...EEEIp..TLRQVLAAKE+HhuE.lK.RKLG........losLpELKQNlu...+uWp.DVpsosAYp+TpE...............................................TLSpAGQKsSAAh....S....slGosIo+KLsD...........................................MRNSsTFKSFE-+Vts....l..KoKVs.usp.ssss.h.p..t...........................................................................	0	40	50	92
+4677	PF00205	TPP_enzyme_M	TPP_enzymes; 	Thiamine pyrophosphate enzyme, central domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The central domain of TPP enzymes contains a 2-fold Rossman fold.	27.90	27.90	27.90	28.00	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.75	0.71	-4.41	309	15120	2012-10-03 09:55:27	2003-04-07 12:59:11	17	40	4534	251	3745	11432	6158	134.60	28	23.53	CHANGED	lppssphlppAc...+P..lllsGuGshhs.p..Apppltplu-ph.slPV.ssThhG..+Gsls.p..........sc................Ph....hG.hhGhh.u.....stsustsl.pp..uDlllslG.sc...hsp.hs......hs..phs.tassp........s..p.........l..lpl.D......................l-s.........scls+sh.............ss.lsllGDsp.......tsLptL	.........................................lpcshph.l..p..p..A.c...+P...l.lhsGuGs...h..s...p.........A.s.p.....p.L...p...c...hs-ph..plPl...s.s...T..h.hG...t.Gs..ls.p............................s.c...................Ph.h...lG..hh....Ght.G......st.su..s.h.sl...pp....uD..l..l..lslG.sR...as.c..ps..tu..........tht..tassp.......s...c.........l..lp.....lD.......................l-s....................sp.l.s.+.hh..........t...sc..lsll.GDsp....tsLpt...............................................................................................................................................	0	1002	2186	3051
+4678	PF02775	TPP_enzyme_C	TPP_enzymes_C; 	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	Finn RD, Griffiths-Jones SR, Mistry J	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.08	0.71	-4.64	327	23243	2012-10-02 16:07:47	2003-04-07 12:59:11	16	110	4932	295	6025	21857	10671	146.80	22	24.62	CHANGED	-lGptph.hhtph.......t.spp.als...ss...shusMGhulPsAlGsp..l....s........s..t.....t.pVl.slsGDGu..ahhs.h.pELtossph..sl.slhlllhNN.phhGhlctt...pp.hhhttphss.p...............hts.DastlAcu.h..Gsp.uh...p.lpsh..pcl...ppslccA...h......ppptPsll.-l	........................................................hGp..h.....................stp..hhs......ss........shus..h..G..h.u..l....ssAlGsph................u...........................p.P.....c.....c..pVl..slsGDGu....h..h..hs..h..p.-..L..s..............s.....s.h...p.h..........sl....s..l....t.....l......ll.l.N.N....p..s.....h....u...h..spt.................pp..hh..h.t..t.p.h..s..s.......................................tth...D..a...s..t....l.A.......pu.h........Ght...sh................pl...p.....s.t..............p.c..l.......pp....s...lpcAh........ppss.ssllch.......................................................................................................	0	1846	3761	5012
+4679	PF02776	TPP_enzyme_N	TPP_enzymes_N; 	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.87	0.71	-4.77	118	17953	2012-10-02 16:07:47	2003-04-07 12:59:11	13	63	4635	275	4426	14362	7899	169.30	28	30.25	CHANGED	hssuchlschLpp.hGlcp...............lFGlsGsphhs.lhcultpt.......tlphlhs+cEpsAuhhAs..uau+..ho.Gc.......sulshsss.GP.GssNslsulssAhts.phPllhlsGpsstpths.........tthhp.ph..D.thsh.....hp..shs.Kh......shplpsssphsphlpcAhptA..hssptGPVhlslPhDlhttpssts.	..................................................................................h.psuphllcsLpp..p..G..V..c.p......................lFG.hP...Gu.shhs..lh-u...l...tppt....................tlc.al....h...sRHEp..........uAuahAp....GaA+.......ho..Gc...........................sG..V.s..lsTS..GP.G.s.s........N..hlsu......lss.A.h.h.-....sl..P...l.lslo...G...pss.sshls.............................pss..aQ.ph..........D....hhsl.........................hp.......sh.s...+a.............................shh.l......p......p......s......p........p.......l......s.........p.........h.......l.......p..............c...Ah.......phA......................s........ucsGPVhlslPtDl..t.h....t.....................................................................................	2	1202	2609	3623
+4680	PF01963	TraB		TraB family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once the plasmid pAD1 is acquired, production of the pheromone ceases--a trait related in part to a determinant designated traB. However a related protein is found in C. elegans Swiss:Q94217, suggesting that members of the TraB family have some more general function. This family also includes the bacterial GumN protein. The family has a conserved GXXH motif close to the N-terminus, a conserved glutamate and a conserved arginine that may be catalytic. The family also includes a second conserved GXXH motif near the C-terminus.	30.20	30.20	30.30	30.20	29.70	30.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.65	0.70	-4.94	137	1980	2009-09-12 01:14:50	2003-04-07 12:59:11	12	13	1569	0	659	1576	259	253.30	21	77.55	CHANGED	hlWclp.....ps.s......pp.........l.................aLlGThHlsctsh..lsstlpphhppu-slslEh...................thhh..s..spplp.shlsscphpplsthhttht..hs.....phhpphcP.hhlshtlshsthpp............thssp.....Gl-.thtttAt.........tpstphhs....LEshchQlshh.psh...shpp....phphlhpsl......pp.h.....tpt.sph..hpp...hlpt.atpuDh....ptlhph.........htp...........thsph.hcsllscRNpt....hspplp..phhppt...........tthhssVGAuHLsGtpu.....................................ll.................................shLpttGaplpth	.................................................................................................................................................s..s.....pph.....aLlGohHh.u.sp.sh.t....s....l....ss....tlhpthppuDslhlEh.....................................h...........s......stsl.p.phl..st.c.p.hp..pL.pph.....p..t.h....hs............................phhpph...a.ls.hh.lt.....htp.hpc.........tlpsph.......Gl-h.th..ttAt..............tppt.hht................................LEstp..Ql.shh...pth.........................s.tt....t..ht.hLts.sl.....................sp..h.....................pss...sch.........hpp.........hhph.ahp.s.s........sshhp...............................hpp.................ht..p.l.hc.s.LlpcR.Ntt......hspplp......th.ttp........................hlssVGAhHLhGt.ts............................................................l..................................................................phLp.......................................................................................................	0	225	409	534
+4681	PF02534	T4SS-DNA_transf	TRAG; TraG;	Type IV secretory system Conjugative DNA transfer	Bashton M, Bateman A, Staddon J	anon	Pfam-B_1146 (release 5.4)	Family	These proteins contain a P-loop and walker-B site for nucleotide binding. TraG is essential for DNA transfer in bacterial conjugation.  These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems [2].  The C-terminus of this domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore [3]. The family contains a number of different DNA transfer proteins [4].	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.47	0.70	-5.91	9	2504	2012-10-05 12:31:08	2003-04-07 12:59:11	9	20	1333	0	409	3978	356	393.00	19	69.09	CHANGED	passhs-hpptt.hhpctshlhs.h.ths..................hGt...hhstsGpF.........ashlhAsotuhKusullIPshLsasp.olVVhDPKuElaphTuphRcppup.cVhlh-Ptsspsp..paNPlDaIsttss..stscDlhtlsshlhsspsh..........................c-aapssAtpLhsul.............hhhhphpstscshstslphlpshtu-.......csh.hsphhpphpssctststpslushhspsc.............cphoSVhushsuphphassP.lpshsStSDFslcclt..cccsslalslsspshphhsslhplhhp.hhphhtpp.sshctp.ht.....sLFlLDEFspLGhhchhcpuluhhttYslplhhIhQoluQLps....tYsppsApohlsspsshlsaussN....-TAcaISchlGptTlchcssSc.....ssspuso+opohs.spRsLlpPcElhpMssccp............IllhpupsPl+scKshYacc...........................pphpsphsc.t.hhstphthu	.............................................................................................................................................................................................................................................................................................................................................................tth.hl.hus.o.tSGK..s.....h...s...h.....l.....h....P....s.....l...............h..........p.......h.....t........t.....S.......h.....llhD..K.......s.....-.......h...........h...........t........h..........s........u.......t...............h.........h.....p....p.......t.......s.......h......c.......l......h........l...hs........................h.................s................p...........p........u...................p.........a...........N.P..h.....t..........h...l.....p...p.....t..........tp........h.h.....s.....h.......t.........l..s..s...h....h...h..s...t.pt.........t.................................................................................t.c..sa.Wtpsup.t.L.hs.uh.........................................................hhh.hh..h..t...t.........t...........s.......h...s.............h.........hp...h....l...t......t.......h.........t....s.t.............................t..h.......h................h..........h..h.t..t.............h......t......t.............t.........................s.........h......h....h...t..t........h...t....t....h......t...t..s.t..........................................................................pphsulhss...h..ts..h...l.s.h......a.....t.............l......t...p....h.h..........s...........t....s.......-...........h.........c..l...p..p..lt..............pp......h........s........la.l.h..h...s...s.....p...p......s...h.............lh.......t..l.h.h..p............h...h.p...h........h.......t...p...t..................t...........t...t..........h....................hhhhh....DEhs.sl...G....h.....h...........h..tp..h..hu.........hhtu.......htlphhhlhQsh....s.Qlpt...................hY.t.p..t.t....h.p..sh..h....s.s...s....h..hh...h..s..tp..........psh..c..lS.p..h...h.Gp.....T....h............s.hs...............................t...................t....p..........s.........s.......p...........t....+....L...h.........tE.lh......h........t..t............................lh....h....t....s..............s.....hh...t..........................................................h..............................................................................................................................................................................................................................................................................................	0	134	274	337
+4682	PF00923	Transaldolase		Transaldolase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_787 (release 3.0)	Family	\N	20.90	20.90	22.80	22.20	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.71	0.70	-5.28	131	6718	2012-10-03 05:58:16	2003-04-07 12:59:11	14	21	4201	128	1447	4243	3165	256.10	30	91.25	CHANGED	lahDssshchIc.....chht...lpGsTTNPolht+......Ahp.....tpthhcctl....pphppt...................................................t.hh..lhh..h..hhthh..........sG.hVShEVss.hshDscuslpcA+cLhphhp........t.slhIKlPuT.....-GlpAhcpLp.pc.G...............IplNlTLlFShtQuhtsAcA.............G...........ssllSsFVuRlschh..........................tt.sGltsspphaphacph.s...................a.sTtlhsASh+sshplh..sLsGsctl.Tlssshlcphtp.csts..........................tt..t....hp.p.hh.ph.s-Glc...pFtpsappLhttl	................................................................................................lhhDTusl..ptl+..........chtt.....h.pGsTTNP.S.llhp........t..........hpt.h.c.-.sl.tphppt........................................................................l........................................sG.plSs.EVsu................h.Ds-shl.pc...A+cLhphhs.......................plll..KlPs.T..............................hp.Gl...pA...hchL...p...p.-..G.............................IpsNlT.............LlFShsQuhhsAcA..................G........sphlSPFVG.Rlt-hh..................................tsGltslpplhphacpa.s....................................h..pTtl.....hu.AS..aR..........ss.tplh.........tL..s..Gs..-h.......l..T.ls..sllpphhp..psts...........................t..ptl.......................................................................................h.....................................................................................................................................	0	481	911	1226
+4683	PF00382	TFIIB	transcript_fac2; 	Transcription factor TFIIB repeat	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.18	0.72	-4.16	12	2462	2012-10-03 00:42:12	2003-04-07 12:59:11	14	23	536	21	1522	2387	745	70.60	26	32.13	CHANGED	ls+hsspLcLsc...hVtcsAtclh+pshcpthlpGRSstulhAAslYlAsRhpphpRohpEIsslspVschol	...................................ht+hssp.L.s..Lsp........pltc...pAtpl...h.c....p...s...h............c...........p.............t...........h.....h......p......G...Rs...s...........pulsA..AslYhA.s..R.....h..p...s.....h..s.+.....o.hc.El.u.sls..p.Vschpl........................	0	455	879	1280
+4684	PF00405	Transferrin	transferrin; 	Transferrin	Finn RD	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.08	0.70	-5.57	10	1389	2012-10-03 15:33:52	2003-04-07 12:59:11	12	15	229	250	465	1509	132	257.20	32	86.39	CHANGED	VRWCslSssEtpKCpsap-pM+pht...sPsloCV+KuSsl-CIpAIAssEADAlTLDGGhlaEAGLsPYsLKPVsAEsYGo+-pPpTaYYAVAVVKKuSsFplNpLQGKKSCHTGLGRSAGWNIPIG..lLcstLsWtG.spcslEcAVucFFSuSCVPGAcc.sthPpLCQLCsGputsK..CusSspEPYaGYSGAF+CL+DGAGDVAFVKcSTVhENLsscA-R........DpYELLChDNTR+PVD-YKsCHLApVPSHAVVARSsssKE-hIWcLLspAQE+FG+-pop-FQLFSSPsGt....KDLLFKDSAlGFl+lPophDStLYLGa-YhTAI+NLRc	...............................................................WCshup..E.t..KCttht.....t......................tlpC.ht.t.t..s..cClptIh.t.tcAD.sh...slD.u.s.la..A.u................h...tLhP....l.hs......E...h..........t....................................t..........t...................t........t.........t............Y...............h......u.VAVV.....+.....+.....s......s.......s....h.......p..............h..............p....p..................L......p........G...+...+SC..Hou.h..s..p.....s.A.G..W.p.l...Ph...u..........h..t........h..........................................................t....h...s..p...aFs.t.u.C.....s.......P.....G..........s.......p...................................................s....p.LCthCh.G.....................................t.........C..t..............s...t.p.-.Y..h.GasGA..h...........+...C.L.h-...s........t......G-....V.AFl....+..........p..........t...........s....l.........p...........s.....h..........t....s........p.............................................ppap......LLC.....s...s....s.....c...t..s......l...s.....p....a....p...p..CpL.u....ps.P.....s+uV.l.s...R.................................t.......l.h..p.hL....p..........t....t.................................................h..phFts........................psLhFpDss.th..h......................h...................................................................................	0	88	121	296
+4685	PF00868	Transglut_N	Transglutaminas; Transglutamin_N; 	Transglutaminase family	Bateman A	anon	Pfam-B_783 (release 3.0)	Domain	\N	21.40	21.40	21.50	21.80	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.47	0.71	-4.07	50	614	2009-01-15 18:05:59	2003-04-07 12:59:11	15	12	106	39	309	576	0	116.20	30	17.57	CHANGED	LplpsVDlpppp...NstpHHTccap..........spcLlVRRGQsFplpLphscs...apsstDplplhhphG..stPs.....spGTpsslsl....spttp......sssWsupltspsusp.....lplslpssssAslGcYp.Lsl.....pspst	.........................tlpplDh....p...pp...N..ptpHHTpcap...........................................spcLlVRRGQsFplpLphsps....a.sst....-plph.hp.s.G......stPs............spGTpsshsl........sstts......sssWsAtl...p.p..psps.......lslslpoPs.sAslG+YpLplpst.s..............................................................	0	56	87	169
+4686	PF00912	Transgly	Transglycosyl; 	Transglycosylase	Finn RD, Bateman A	anon	Pfam-B_558 (release 3.0)	Family	The penicillin-binding proteins are bifunctional proteins consisting of  transglycosylase and transpeptidase in the N- and C-terminus  respectively [1]. The transglycosylase domain catalyses the  polymerisation of murein glycan chains ([4]).	20.70	20.70	20.80	20.90	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.16	0.71	-4.96	172	12887	2010-01-08 14:08:55	2003-04-07 12:59:11	17	38	4268	62	2627	9890	3274	179.10	35	26.43	CHANGED	sG......t.ltth........tpp+phl.s.hs..............p.l...s.t.......lhpAllusEDccFap......HtGlDhtulhRA.hhpsl.t...sspht.......pGGSTITQQlsKs...h.hL..........p........p.....+o....h......pR...KlpEhhhAhpl......Epp..hoKccILch.YLNpl.h.G.p....ssaGlpuAuphYFuK............sspc..Lshs.....EuAhLAulhpuPs......ta....pP..h......p......scpspp....R...pshl.LppMh	............................................................t......ph........tppRhhV.s..hc................p..l.....sst.......lhpAllA.sEDp...+F.ac.............Ht.Gl.DhhulhR....A....h....hpsl..h................................su.pts...........pGGSTlTQQlsKNh..aL.................s.....................p-..............+o.............h....tR.............Kh.pE.hhl.A.lpl..................Epp....h.o......KccILph.YLNp.lah.G..p......ssaGlpsAAptYFG..K...........................sspc........Lols........................puAhLAGlsp.uPs..........tY.sP.....hp..s...................sctutp.........R..p.s.hV.LppM............................................................	0	760	1609	2146
+4687	PF00456	Transketolase_N	transketolase; 	Transketolase, thiamine diphosphate binding domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4.  Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.87	0.70	-5.63	12	11328	2012-10-02 16:07:47	2003-04-07 12:59:11	16	27	4696	96	2755	11612	8619	262.80	31	48.34	CHANGED	.cpphsssIRhLuhDAVppApSGHPGuPMGhAslApVLapchL+psPssPpWhsRDRFVLSNGHuuhLLYuhLHLsGY.DLsh--L+pFR..QltS+TPGHPEhtassGlEsTTGPLGQGIuN...AVGhAlAp+sLAApaNcsGasIsDaaTYVhhGDGCL.EGlSpEAsSLAGpLpLGpLIshYDcNpIoIDGcsphtFs-Ds.ttRacAYGWHVlts..sGcDspuIptAltpA+tsps+PoLIts+TlIGaGussptGscssHGAPLGs--ltth+pthGac.ttsFtlPp-lYstapt+ht..GtptpppWpphFusYtptaPEhuAEhtRRhsGcLP	.................................................................................................................h.....ptlRh.s..hphl.t...pu..t...........u......G.......H................G..s......s..huh.A..sh..h...s.L.a..p....c...h......h.p...h.p...P.t.......p.s.........p......h..........s.R.D..R..a.lh.....S........t.GHu.u.hlYuhLa..L............p.............G...................h..................l............s.h.....-c.L.c.s.FR..........p......h.....t.......S....p........s....s......G..........H.......P.c...h....t.h................s...G..........l....-.h.o.TGsL.G.p.Ghss....AlGh..A...h...u...p...+...h...h...t...t................t...........................h.p...h.......s..p.......h..sY...s..hhGDGph.EG..uh..........E........A..........hs....hAup.p....L.s...pLlhhh.D.s.N..t........h...p......l........D..............G.....................s..........p.........h.............h........h.........s...........p..........c............h.........t............t.....+..........a....c.u.....h.......G..W....p.V.....l.p......s...............s....G..........p...D....h....p....t....l.........t....A....h.......p....t....A.......p.......t..................s.......+..............P.olIhs.+.T..h.h...G..h..G..............s........t........h.......t..........s..........p......t.....t......s.......H......t..........t.................h....s................p......t...h.......t..............h.h.......t........h.........................................................................................................................................................................................................................................................	0	827	1666	2288
+4688	PF01818	Translat_reg		Bacteriophage translational regulator	Bateman A	anon	PSI-BLAST 1reg	Domain	The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs [1].	25.00	25.00	73.20	73.00	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.63	0.71	-4.58	11	74	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	70	2	0	56	724	121.60	58	92.25	CHANGED	MlEIsLpcP-DFLKlRETLTRIGIANsK-KpLYQSCHILQKpG+YYIVHFKELLpLDGRpVclopEDhpRRNsIApLLcDWGLspIlssc...-hsspNpFRVISaKpKsEWpLhsKYpIGp	.MlElsLpcP..-D...FLKV+ETLTRIGl.AspK-.KpLYQSCHILpK......pGpYYIVHFKEL.htLDG+psslocEDh.RRNpIspLLpDWGLlcIlsspthhc.hssh..Nph+VIoaKpKsEWpLhsKYsIGp...	0	0	0	0
+4689	PF01997	Translin	DUF130;	Translin family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family include Translin Swiss:Q15631 that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen [1].	20.40	20.40	20.60	21.00	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.33	0.71	-4.72	74	629	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	351	42	428	614	144	190.20	24	78.99	CHANGED	cctREcllclsR-lsphS+cslht................lHptst..........tt.st.phlpcsppplpplp.phht...............shs.........apaptthssuhQEalEAhshhtal...........................pst....pLhohc-ls..h.............................................................ls.t-YLhGlhDlsGELhRhslssltpGshcp...................................shplhphhcclasthhhlsh...............th......tslR+KhDsh+pslcKlEpslashpl+st	...........................................................................................................phRE.clhchs+-lpttu+chlhh...................lpphpt............................tp.sp.chhppsppplpp.lp.phht................sts....................hapappthp.slQ-h......l.puhsahtal...........................c.sp....sL.l.ohc-lsp.l.h...............................................................h.ls.p-YLhGlhclsuEL.....h........Rhsls.slst.G-.hpp.........................................shplhp.hlpcl.hssaphlsh..................................................ptl.+.++hDsh+.s.......lcKl.EpssYslplRs.h.............................................................	1	140	221	335
+4690	PF02133	Transp_cyt_pur		Permease for cytosine/purines, uracil, thiamine, allantoin	Mian N, Bateman A	anon	IPR001248	Family	\N	21.10	21.10	21.10	21.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.43	0.70	-5.93	14	4605	2012-10-03 01:44:59	2003-04-07 12:59:11	10	14	1918	2	1514	3768	1528	398.50	19	86.59	CHANGED	PVsp.ccRshshhNhhshWhusshslssashuuss.lthGLsaapshlslhhusllsshhlsltuthGsphGlshslhSRuSFG.lhGulhPhlsts.lhAhsWaulpsalGupslhhhltplast....hhs...sh.ssssh.hlsFhlFhllphhhlahshpplp+hhshtuhlh.hsuhuhhhWshstspu....Gslhs..st.s.........hhsulhuslusauohlsshsDFTRaups.psshhsthlslshshslhhhhullssuuuhsh.hGsshWsshplltpa.ss.......hushlhslllshuplusNhusshlusGhshuslhP...hhlsh+puuhhsullulshssWsLhusssp...hhshLshhushLushuGllhADYahlR+uhhplsphat....psuhYha..chGhNacAhsAalsGhhhslsGh..........tsshsshthhsluYhVG	.....................................................ppR...p....h....t....h....h.s.hhs...hWh.u.sshsl.s.s.hshuu.hh...h.................h.................h...........G...Ls...........hh.pshlulllGshlh.s.hh.hsh...h.uh.hGsch.GlshhlhsR.h.s.F............G...h.................h.G.u...h.................l...ss.l..lt.s...lh.t.l.........u....W.............au..hps.hhu..u..........t.s...hthhl.s..p.h.hs.....................................hs..h.s.hh.l.s.....h..h..l..h.h..l.l............h...h.h...h...h..h.G...h.....p..s.......l...p...h.h...t...h.ht........s...........s.....h...l...h.l....h..h...h...s...h...h..h..h...h.h.sp.s.sh..........u....h....h.t.........t.s.....t...............hh...s..u..l....s....h..s..s...u..h....a................h.s....h....ss....hu...Da.oRa.......s..p.s........t..p.....s............s......h......h..........s........t....h...h....u....h...h...h..s...h....h...h.h....h.h.....h...u....h...h.....s...s...u...s..ssh...h.............s....t......s.......h....h......s.......s...h...................................h..s.....................uh.h..l..ss.l.l..l.h..h...h..s.l...s...s..s...s...s..s.....s.......h..........h....u..s..u...h...s.h....s..s...l...hs....................h........l....s..h..+...t.....t...s....h....l.....s..u..l.....l....u....h.....l....h....s....h..t..l..........h....s..s........sh................hh..a.........Lshlus.hlsPlh.....Glh.l.sD.Ya.l.l.+....+...t.p.h...p...hst.h....h.............................t..h...................s.h.......N........h...h...u..h...h...s......h..h.h.u.h..h.hs.h.h.....................................................................................................................................................	1	391	822	1249
+4691	PF04236	Transp_Tc5_C		Tc5 transposase C-terminal domain	Bateman A	anon	Pfam-B_2955 (release 6.5)	Domain	This family corresponds to a C-terminal cysteine rich region that probably binds to a metal ion and could be DNA binding (pers. obs. A Bateman)..	27.40	26.40	27.40	26.40	27.30	26.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.48	0.72	-3.75	14	75	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	10	0	72	54	0	58.60	37	15.42	CHANGED	WpKuGYh...spss.sFhTPupaC.Fs.cssssDChhsGCschuFI+Cu+CcphlCFcHFlV.phHhC	........Wa+uGYh...ss+Ps...tFcTPs-ah.Fs...csstssCsh..Csphuhl+CsaCcp.hCFscFh....H.C......	0	16	22	72
+4692	PF00872	Transposase_mut	Transpo_mutator; 	Transposase, Mutator family	Bateman A	anon	Pfam-B_376 (release 3.0)	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.15	0.70	-5.91	14	6867	2012-10-03 01:22:09	2003-04-07 12:59:11	13	34	1819	0	1273	6707	991	221.60	22	89.13	CHANGED	hspsp.hsthtth.sh...thsuts-hhcshhcshhpplhpsEhschlGstcaERsttRp.st.......RNGpps+slsTpsG.pl-lplP+sRsGsF.P.......sllp+hpRp-pulpuslhphYlpGlSTRclpchlptLhG.pt..lSpupVSplscplc-tltsapsRsLpcs.asalalDAhahKlR..sspVhupulhlAlGlssDGpR-lLGhtls..suEutphWpshLpsLpsRGLps.lpLlluDuatGLspAlstsasssshQRChlHhhRNlhstss+cpt.cpltstl+sIapAs-h-tsttth-thhsthss..+aPtlsshh-cuhpcllsFhsFPtsha+plhoTNslERLNcElRRRs+shslFPNtsohlRLlhslLt-h......cccWhtu	..............................................................................h...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................................h.....h.os.N.......Et.h.......h.+..t.............................................................h......................................................................................................................	2	397	800	978
+4693	PF00273	Serum_albumin	transport_prot; 	Serum albumin family	Finn RD	anon	Prosite	Domain	\N	25.50	25.50	25.80	25.50	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.31	0.71	-4.84	42	692	2012-10-01 21:15:37	2003-04-07 12:59:11	15	8	71	324	248	788	0	168.30	26	84.70	CHANGED	ppphspphpphG-cshpulsllthSQth.pssacElsKLlp-lsphtcpCsts-.....pChcshtshhhcclCpppshhs..utlscCCpcstsE.RspChhphcp-p.sth.shth.....s-scchCpsapcspctFhu+alaEhuRRHP.hhss.lLtlAppYpphlpcCCp..sps.ssCh	..................t.pp.Ct.hpphGccthpsh.hllt..hop+hPpsshp-lhplsp-lsphtp...cCC...p..s...st....hsChcs....ths.....lhsplCpppph.hs..splscCCscs.h.h.............p.Rp..Chhth.csDps...........shp....t............stsc-lCpt.pc.spp..thh.s.........p...a..........LaEhu+..++Pp.hsts.LhplsppapphlpcCCp..sps.tsCa..................................	0	11	18	55
+4694	PF01359	Transposase_1		Transposase (partial DDE domain)	Bateman A	anon	Pfam-B_394 (release 3.0)	Family	This family includes the mariner transposase [1].	22.90	22.90	23.00	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.44	0.72	-4.21	63	449	2012-10-03 01:22:09	2003-04-07 12:59:11	13	27	113	11	235	404	0	74.10	30	26.29	CHANGED	hY-..N.pRp+sWlpsGpssps.ssKsslas+KlMLsVWWDh.cGllaaELLtsGpTlsu-hYppQLp.cLppslpcKRPphhsR+	.............................a...s.pcp.tpWl...p.sp.s...p...ts.Kspl.atK.K...hhLslaWsh.p..Glla.a-l..LssGcTIsu-hYspQ.Lp.cl...tptlpphp.t.............................	0	51	123	182
+4695	PF01610	DDE_Tnp_ISL3	Transposase_12;	Transposase	Bateman A	anon	Pfam-B_1015 (release 4.1)	Family	Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204 (Swiss:Q50911) [1], IS1001 (Swiss:Q06126) [2], IS1096 (Swiss:Q50440) [3] and IS1165 Swiss:Q48788 [4].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.56	0.70	-4.80	128	7865	2012-10-03 01:22:09	2003-04-07 12:59:11	12	34	1808	0	1018	5504	425	158.50	24	62.84	CHANGED	lGlDEhphp+.tpp..hhshht.h..ct...........pplltlhtsRsppslppahp.h.s.p..pppplctVshDM.ssatsslpphhPp.Ap..llhD+FHllchhsc.ulspl...Rpp.hpph.......tt..............................lKps.+all..LK........p..cpLspp.pttp............ht...hh....pt.s...pltpAYtlKpphtpha...p.p........p....httupp...hhppWhpth.......tstls.........hpchscolppahptIlshFc..............hoNGhlEGlNs+IKsl+RpuhGa+shcphpt+l	...........................................................................................................................................................................................................................................................th.......hht...th.............................................................................h..ht....hhhh..............................t........ht....t...............................................h.....hh.............t.......h..hh.h....ht....hh.hh.....p.t...................................................h.t....h..tp.h..................h...................htphhtt.h....p...ht..l.h.shht......................ho.Nu.hEu.hNthl..+.hc..p.shGhts.t.hh..........................................................................................................................................	0	276	676	802
+4696	PF01710	HTH_Tnp_IS630	Transposase_14;	Transposase	Bashton M, Bateman A	anon	Pfam-B_1769 (release 4.1)	Domain	Transposase proteins are necessary for efficient DNA transposition. This family includes insertion sequences from Synechocystis PCC 6803 three of which are characterised as homologous to bacterial IS5- and IS4- and to several members of the IS630-Tc1-mariner superfamily [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.57	0.71	-4.44	9	1697	2012-10-04 14:01:12	2003-04-07 12:59:11	11	12	366	0	262	1502	90	102.50	39	76.09	CHANGED	MAYSlDLRpKVlsalEsGGuITEAS+lFpluRsTIYpWLp.+Echush+spsRpp...KlDp-cL+pclcsNPDhhLpEhA+cFGV..pPuolpYthK+MtlTRKKpshh.cpt..+.sphppshs	.........................................YShDhRp.KV.l.s.h.h.E.c.s.t.o.h.oE.AS....c....l.......F.......p.......l......S...R.sT.Ia....tW...Lc....hK.......c...c...T........G....-....h.....p.....p.......p....s.....+....t....pp.......tK.l.....D......h...c...c...L...K...s.a..l....p.....c...p......P.......D........s...hl...p......E......l......A......p......c......a......s......s......pss..o..lp.h..ALKt.hGhT.p.KKp..........................ph.......................................................................	0	52	103	234
+4697	PF01797	Y1_Tnp	Transposase_17;	Transposase IS200 like	Bashton M, Bateman A	anon	Pfam-B_1347 (release 4.2)	Family	Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.40	0.71	-4.25	178	5614	2012-10-02 12:35:40	2003-04-07 12:59:11	11	33	2186	40	1185	4727	578	98.60	26	68.64	CHANGED	hhphpaHlV...assKYR+pl.lssp.ltpclccll.pplspphphcllp...hsstsDHVHlLlphsPph.ulScllptlKutSS+hlp..pcasphhpphhh......h..WspuYassosG..ss.shcslccYIcsQ	.......................................................................................h.....hahh...hh.sp..Rp..th..h.tp...h...t.........pthtp.hh.tp.h.s.p.....h.........t.....h.p.lht..........h.p...h.....s.DHlH..h.L.l.......p...........h..........s.........s.....p...........h.......s............lo......p.......h....h...th.lKu.t.o...u.h....h....lh............pp.....h...........p..h.....t.....h....+hh..................tth...W.s.p.u..Ya.sp...oss...t....s.thlt.p.YIpt..........................................................................	0	388	819	1034
+4698	PF01385	OrfB_IS605	Transposase_2;	Probable transposase	Bateman A	anon	Pfam-B_1210 (release 3.0) & Pfam-B_4602 (Release 7.5)	Family	This family includes IS891 [1], IS1136 [2] and IS1341 [3]. DUF1225, Pfam:PF06774, has now been merged into this family.	19.00	19.00	19.00	19.00	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.55	0.70	-4.96	39	7021	2009-01-15 18:05:59	2003-04-07 12:59:11	14	26	1439	0	1819	6621	252	194.50	20	55.24	CHANGED	ppYp.plsutssQpslccsspAacSFFshhcthcpt........sphP+Yppc....pt.........phhlhhppsphp....hcpsplplsh...............hplp.hcsphphchc.....ps+lhhhhpth....spahsplsh-.hpt......................spspssptsuIDlGlssLsslssspst.......hlhpu.+.ltut.phhs+phuclppp........hptpt........p+ssc+lp+LapKpspphcchlcphsppllpphhph..slpslslGthpthp	....................................................................................................................................th.s..shptsht.ph.....pu....a.pp.ahpth............................................thP..p....a+pc.......t.............................t.....h......p.t...t..t..hp................ppt.....t..l.hlsh............................................h.t.......h..p..h.....t...p.p.p.h..t....................thp.t..h...h.l.tpp..............spaal..s..l....hc...hp.....................................h...t.s....s.p.h....l...G.lD..l.....Gl..p..p..h.s..s..h...o..s..u.p..............................h..p...s....p...............h..p....p....h.....p...p...c..h....t....+..h..p..+..p.l..s....++......................................hptupp..............hp+tptc......l....t.+.....l...a.......p.......+ls....sh+p........Dhh....+..+l..oppl..sp.p..h.t..hh.....sl.EsLthtsh....pp............................................................................	1	529	1255	1605
+4699	PF02992	Transposase_21		Transposase family tnp2	Griffiths-Jones SR	anon	Pfam-B_1531 (release 6.4)	Family	\N	25.40	25.40	25.40	25.40	25.00	25.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.29	0.70	-5.26	49	1289	2009-09-13 07:43:22	2003-04-07 12:59:11	9	104	66	0	750	1419	1	149.60	32	20.18	CHANGED	chhRWHtEp+p..pDGh.hRHPuDupsW+phDcpaP.-FAs-sRNlRluLuoDGhNPFu..uspaShWPVllhsYNLPPhhCMKpp.hhLolLIsGPppPGssIDVaLpPLl--LppLWp.pGVcsaDs.ppcpFsLRAhLlaTIsDaPAhu.LSGhss+Gph.ACshChcpTtuhhLcpupKhsahs.HRRFLPhsH.aRppcptFcss..hEppssPp.h...oGcclhpplcslp	................................................p.............................................................................................................................................................hh.G....P.ppP.s...p....s.....l......s..s..aLpP......llc-lt.L.ap....tGh............h..........h........c.t..t.p......p....h...l.+shlh.hshsDhPAht..t.l.u.G..........p.u.h..h.....uC..h.C.p.h..h.......h.....tt......+.........a.t.......h........................................................................................................................	0	205	337	361
+4700	PF02994	Transposase_22		L1 transposable element	Griffiths-Jones SR	anon	Pfam-B_2299 (release 6.4)	Family	\N	25.00	25.00	25.00	25.00	24.10	24.90	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.27	0.70	-5.96	3	1528	2009-01-15 18:05:59	2003-04-07 12:59:11	9	29	45	16	1329	351	40	221.10	32	80.72	CHANGED	+GKRRNhoNRNQDapuSSEPsoPTSuSPusPNThENpDLDpKuYLhMMlEGlKKDspsSLREplEspuKElQpsLKEhcEsIsKQVEshpEcoEKohKElMEl.......................pKpl+ELKcEl-oIKKpp.EsTL-IEs.tK+pGslDhShoNRIQEMEERISGAEDSIEpIsoTlK-NsKpKKlLsQNIQEIQDolRRPNLRIIGV-ESEDpQLKGPsNIFsKIIEENFPNLK+EhslsIQEAYRTPNRLDQKRNTSRHIIVRToNApNKERILKAVREKGQVTYKGKPIRITPDFSPETMKARRuWTDVIQTLREHKhQPRLLYPAKLSIIIEGETKlFHDKTKFpcYLSTNPALQRIIKE..KsQ+KNuspsLEcsR+	............................................................................................t..........................................................................................................................................................................................................................................................................................................................................................................................................t.....l.......s...s.Rh.pph....E...-.+.IS.p.lE.......-.t.................c.h.......h....p.......s...p...........c...p.......c..............t......c..............l..............+...p..............p.......p.p....lc...-.......Lpsp.h.......+..R...s...N.lRIIG...lPE..G.pc.....p..t...c.s..s....p.sl.h..pcIh.....t..E..N..hP...s...L....h.c...ch.c...lplp.c..A..p..R...s..s.sh.h..s.s...c...c...s...s.....P...R..p.Ill..K........hh....+.hpsKE+.....IL+s...ARp.+.....p.ls.....a.+..G......ps...Ip.l......sD..hSs.-s.hptR.R.ca.pslh+.L+c+.sl.p.p...l...hYPu....+lp.hphp..G...c.hp.....F.s.t...h...........................................................................................	0	10	330	417
+4701	PF03017	Transposase_23		TNP1/EN/SPM transposase	Griffiths-Jones SR	anon	Pfam-B_1491 (release 6.4)	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.23	0.72	-4.46	33	134	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	10	0	57	124	0	67.50	30	18.45	CHANGED	ppss..KChllDWssscc.lVuEGchpSs-P...pphV.splPLGPsAspVhVcslh.s-AhlWRPssplhhlt-ulGs	......................hhsh.t.pp.hVAcuplhStsP...pphV.sshsLG.phscVlVcsV...h.p......p-AhL.RPhsplphhtDAl................	0	0	41	49
+4702	PF03004	Transposase_24		Plant transposase (Ptta/En/Spm family)	Bateman A	anon	Pfam-B_1902 (release 6.4)	Family	Transposase proteins are necessary for efficient DNA transposition. This family includes various plant transposases from the Ptta and En/Spm families.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.80	0.71	-4.30	40	501	2009-01-15 18:05:59	2003-04-07 12:59:11	9	46	31	0	204	486	0	114.70	17	21.72	CHANGED	sschWpshl.....paWpoccuccpScpsppsR......uhuh....hhHpuGppSatpltcchcpch.......scpsshh-lahcTHp.+sDGo......alcp+ucplhcphppplpcp.sphsstsst.s..................phscla...........................hpssutcc+.GRha..GlGuhtpsh	..............................................t..t.Wt.hh.....th.Wt.s...c.hpthStpsptsR.......ttht.......hhHpsGo.....coas......thtcp..hptc.....................sp.ss.hh.......clahps+..p..p..psGp...........stt.s.pp..h..hp...t...........hpp.htp.....t.............................................................................................................................t....................................................................................................	0	4	77	124
+4703	PF03050	DDE_Tnp_IS66	Transposase_25;	Transposase IS66 family 	Bateman A	anon	Pfam-B_2526 (release 6.4)	Family	Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.98	0.70	-5.18	126	5890	2012-10-03 01:22:09	2003-04-07 12:59:11	9	35	1314	0	841	6700	1022	192.80	29	59.76	CHANGED	+uhsusuLlApllssKasppLPLYRQpphhsct.Gl.plsRuTlusWhtpsuph.LpP.lhstlpptlh.psshlasDETslplLt......tp...sc.sp.pualWshssst................hlhapass...sRu.upts.pph.....Lts....ap......hLpsDuYuuYsp.lh...........slpc..ssChAHsRR+Fh-shpt..................shuspuLpt.IspLYt.......lEpch.......p................s.....-.......pRtthRpppupPllsphcpWhp.....tph........tplsspotlucAlpYhl...sphssLhpalcDGcl.plDNNhuERulRshslGRKNa.LFusotpGuct	..........................................................................h...h.....s....p...t.htt....G...h....lstt..hst.h.h..........ht.....ht...h.....t.....h....t....lh...........h..l..tsD-ssh.....................t.tp..sh.h.Whhhtst.....................hhha...h..t..t+t..t............h.........h...............ht...u........hl...sDt....ht....sat...h.....................h........hChs...H.h.....p..Rt..h...ph....................................ht.hlt.........htt....ha.t.................................hc.t...th.t.....................................p...................ttht.R.p...........lh.t.t.h..t.hh...................................................ph....t.s...h.tp.u.h...t.Yhh....pph.t.h...ahps..u.h..hs...NNhsEpslR.hsls...++s.hh.ts..us..........................................................................................................................................................................	0	197	489	640
+4704	PF03400	DDE_Tnp_IS1	Transposase_27;	IS1 transposase	Mifsud W	anon	Pfam-B_2448 (release 6.6)	Family	Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.65	0.71	-4.04	2	3369	2012-10-03 01:22:09	2003-04-07 12:59:11	8	11	576	0	195	2345	250	104.30	60	82.31	CHANGED	hllC.EhDEQWuaVGuKuRQ+WLaYAYsphptsVlAasFG.RT.tThtcLhuLLoPFslshhhoDsWs.Ytpcl.tchHlhtKhaTQRIERpNLsLRp+ltRLuRKolsFS+SVElH-KVIGpalph+ha.	.............................................................h..DEpWuaV....G.uK....u....R..Q+W.LaYAY.c........php.c.sV.l..AaVF.GcRT........hsTlt.........+L.h.u.....L..L....o.s..F.....c..V.s...l..aMTDGW.PLYESR..L........K.GK..L..H..V..I...S...K.R..Y..T..Q..R...IE.RHNLNLR......QH...LARL...u...R.KoLSFSKSVEL...HDK.VIG.aalph+aa..........................................	0	49	122	175
+4705	PF04195	Transposase_28		Putative gypsy type transposon	Bateman A	anon	Pfam-B_1755 (release 7.3)	Family	This family of plant genes are thought to be related to gypsy type transposons.	20.10	20.10	20.20	20.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.09	0.71	-4.99	2	725	2009-01-15 18:05:59	2003-04-07 12:59:11	7	21	14	0	419	710	1	151.90	37	20.83	CHANGED	MActptsh-uphhPsshh.pphpthls+chhPtpthht.hsAhGEuhPTPch..csVhF.pFhhsGhs.Ph.pFFhsILEFYslphtHLsPNulhhlA.FhHhCEhFlGlRPphhLFphhFhlp....hS.PhVVGGshFQ.RGpl.p+Yhshsh+pp.csW+usWFYs..s-.A...LPp.s.	......................................................................tph....p.hls+thh...P..tp..t..hh..t.h.h...h.G.E..u.h.PsPph....csV.hF.sFhh..uGhh.....PhSpFFh..s.lLpFYslphtHLsPNulhplAIFsHlCEhFlG.l...c.PphpLFRhhF..hlps.........hs..s.....s.........V.........s.........G.....u.......sh.Fp.R.s.sl....p..+...Y.h.sh.s...h.+pp..c...s.W+upWFYh.......sp..s........................................................	1	0	19	24
+4706	PF04693	DDE_Tnp_2	Transposase_29;	Archaeal putative transposase ISC1217	Mifsud W	anon	Pfam-B_5730 (release 7.5)	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.09	0.70	-5.43	3	202	2012-10-03 01:22:09	2003-04-07 12:59:11	7	3	27	0	42	452	37	154.30	27	83.72	CHANGED	MsKEL..sRpEYYKALccAlsplhhuMTGlRKDVAsRLlLGuVlGGsAT..EIAQss-MDYETVLKNLDKLANs..cLIElVKKlVtDHPVlLIIDDTHDHKLYARAhPV.SRNGsQhFYCRsHKRFEPAIQLLlIAlKDLssNcoYlIsIIPYIPRKVtE.LKcRGEcuEFKTKI-hhLEhLsoLhscaNVsslVFDSWYVNSKTLpGNTVGELKSNuRVVE...........G-RHVPVuEFPpGEYLVEYL..GTPIKLLVIDsYKchGRRYFFSTDLNDTsEDIITTWENRWDIEVLIRELKALGLEcSSFLTWlRNpGFlsLKALSLLlVpsFKYSLGL+LG	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	23	23	41
+4707	PF04740	LXG		LXG domain of WXG superfamily	Zhang D, Mifsud W, Aravind L	anon	Pfam-B_3568 (release 7.5)	Family	This domain is present is the N-terminal region of a group of polymorphic toxin proteins in bacteria. It is predicted  to use Type VII secretion pathway to mediate export of bacterial toxins [1].	22.30	22.30	22.40	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.12	0.71	-4.53	35	970	2012-10-01 21:44:22	2003-04-07 12:59:11	7	41	392	0	96	785	2	186.40	20	39.12	CHANGED	KplDspplhstl-pptpphcphppplpslcpulpslssLcs..LpG+uuculKsaapshahPlhpthhphl-phpphL.pplpstlpsh-stssuhI-psFLcpEL..ppuls+scphhpphpppl..sshhsslsDllpls.hsppshppplppApcchpcsl-+LtshDpptsshhspscsthptlpphlppLpshh.ssut........pssuYp	....................................th.t..pph.t..pphppphpslp...p.ulpp...h...hssss...L.pGcuhsusKsaappshhPlhps...hhphh-thppth...tphl.p.p.apupV.-.s...s..p.shlc.p.shLc....-l.........pplsp..pp.h..pshp...p.p.h........pp....h..h....s.s...t..p................h..s......p...ph....hp.......ph....tptp...+.clpcpLc...+Ltp...F.s...p.pp.s.p...ap.ph.p......ph.p.lppslpplpshh....................s......................................................	0	29	53	79
+4708	PF04754	Transposase_31		Putative transposase, YhgA-like	Mifsud W	anon	Pfam-B_3820 (release 7.5)	Family	This family of putative transposases includes the YhgA sequence from Escherichia coli (Swiss:P31667) and several prokaryotic homologues.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.06	0.71	-4.96	54	3243	2012-10-11 20:44:43	2003-04-07 12:59:11	7	7	798	0	393	1853	67	186.50	44	64.84	CHANGED	sPHDulFKphhspspsA+-FLchaLPspltplsDLsoLclEssSFl--sL+ppaSDlLaSlcspp............t.cG.....YlYlLlEHQSpsDphMAaRLh+Yslshhp.......+H.hct..........scpp.LPlVlPllFYHGpps.ashshsah-hFs.....sstlAcplhstsa..LlDloshsD-EIhp++p....huhLpLl.KHI+.pR.Dlhchlcplsplltphhpscpplp	.............................................................................pPHDAlFKpFLtp.s.-.sARDFlp.....lHL..P..t...l..+..plCD.......L....pT....L....+..L.Es.s...S..F.l.........-....c..s...L.....+.....t.....h.a.SDlL.aS...lcTpp.............G...sG.....Yl..Y.s..l..I.EHQSps-.phMAF..R.........hM.....R.....YuhAA..MQ..............+H..L.-t...............................sa.c.p......LPLVlP....l......LFYHGppo..PY..P....a.S.h..s..W...h.DtFs........sPt.lA+pl.Y.s..p..sFP...LVDlT.lh..PD-..E..Ih..pHR+.........hAlLE.L.l..Q.K..H...IR.pR..DLht.ll.-pl.ssLLsps.ssspQ.p..................................................................................................................................	1	151	264	314
+4709	PF04986	Y2_Tnp	Transposase_32;	Putative transposase	Moxon SJ	anon	Pfam-B_5271 (release 7.6)	Family	Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases IS1294 and IS801. This is a rolling-circle transposase.	20.70	20.70	20.70	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.12	0.71	-4.54	65	1246	2012-10-02 12:35:40	2003-04-07 12:59:11	8	16	499	0	183	1121	344	156.80	27	48.81	CHANGED	GhhuVLHTaGps.LsaHPHlHhllsuGGlstss.....pWtp....sp.t.ahhss+sLuphaRsphlptLppth.t..h........h.t.tthsthltphhpc................................................pWsVhsp.shs..pscssLpYLuRYhpRssIospRlhphs......sspVsF+a+Dhc...............sscpcphsLsstEFlcRhlhHVL.PcGF++lRaYGhLu.....ttcppp	...................................................................................................................Ghhshlppa.Gpt.hphpsHhHh.h.sGshsptt.........................hhh.hch....tp..hhphh.phl.pt.h.th.................htpttt.p.hh.pthtc..................................................tasl.sthhht....ssp....psh....tYLuRYlp+sslutpRLtt.hs.......tspltaphps.p...............ppppphhhhss.-FltRhhhHls...thp.hhRaaGhhu.......pt........................................................................	0	73	119	151
+4710	PF01498	HTH_Tnp_Tc3_2	Transposase_5;	Transposase	Bashton M, Bateman A	anon	Pfam-B_462 (release 4.0)	Family	Transposase proteins are necessary for efficient DNA transposition.  This family includes the amino-terminal region of Tc1, Tc1A, Tc1B and Tc2B transposases of C.elegans.  The region encompasses the specific DNA binding and second DNA recognition domains as well as an amino-terminal region of the catalytic domain of Tc3 as described in [1]. Tc3 is a member of the Tc1/mariner family of transposable elements.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.15	0.72	-3.92	26	1241	2012-10-04 14:01:12	2003-04-07 12:59:11	13	82	129	7	1065	1248	10	65.70	24	22.63	CHANGED	cRpIlphlccsPp...hohpcLtpphtp..GhslSppTlp+pL+ptGhpu.pps+++Ph.Lotcpt+sRLpFAppHls	...............................................................ostclttpl...............s.h.slStpTlp+hL.+p.t....G.h..tu..p...ht.h+.K.P........h..Lo......t....pppct.RLtaAptH.............................	0	570	817	1048
+4711	PF01527	HTH_Tnp_1	Transposase_8;	Transposase	Bashton M, Bateman A	anon	Pfam-B_527 (release 4.0)	Family	Transposase proteins are necessary for efficient DNA transposition.  This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.29	0.72	-4.02	45	12930	2012-10-04 14:01:12	2003-04-07 12:59:11	15	69	2688	2	2404	10672	1730	75.20	20	64.00	CHANGED	hpp.pRaocEhKtplVcps...csGtslsclu+chGl.ssssLapW++ph..........suhtssssp....................h.hshpp-spcLc+hhsc	................................tpppa.otE...h...K.h.......p...h...l.p................s.........h........c........s.......s........h........s........l..s.......p.........lA..c....c....h.....Gl..s.s.s.....s.l.hp.W.h+.php................ts.t.s.s..tp...........................................h.t..ptc.tpLpt....t..................................................................................................	0	628	1441	1931
+4712	PF03221	HTH_Tnp_Tc5	Transposase_Tc5;	Tc5 transposase DNA-binding domain	Mifsud W	anon	Pfam-B_2955 (release 6.5)	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.26	0.72	-4.16	194	2088	2012-10-04 14:01:12	2003-04-07 12:59:11	11	91	246	2	1635	1984	4	63.10	21	13.60	CHANGED	hsph-csLhpWlpph...pppshslosphlpppApp.lh................ttsshpsSps.....Wlp+FhpRa..slptpp	...................................t.EctLhpWlhph......pppG....hs.......s.otphlpppApp.lh...........................tts.shps.ups.......Wlp+..FhpRa...tlt...h.......................	0	469	953	1437
+4713	PF02281	Dimer_Tnp_Tn5	Transposase_Tn5;	Transposase Tn5 dimerisation domain	Mian N, Bateman A	anon	Pfam-B_5683 (release 5.2)	Domain	Transposons are mobile DNA sequences capable of replication and insertion into the chromosome. Typically transposons code for  the transposase enzyme, which catalyses insertion, found between terminal inverted repeats. Tn5 has a unique method of self- regulation in which a truncated version of the transposase enzyme acts as an inhibitor [1]. The catalytic domain of the Tn5 transposon is found in Pfam:PF01609.  This domain mediates dimerisation in the known structure.	21.40	21.40	21.40	21.40	20.70	21.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.43	0.72	-3.93	2	403	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	154	6	49	283	17	97.40	52	31.63	CHANGED	EuhTlP.hLRtpGLlcEActVEuQSs-TVLp.DEhplLhhhsKs+tc+tptAsSLpWAY.uIA+LGGFhDoKRTGIASWsAlWEGWpsLQS+lsGahsAK-hhApG.pl	.............hhlssplhs.........R.hGl.pE.....sps-SCEKILTPoEWKLL.W.l+lcGK.....LP..sQhP.TLK.........WAsLpLAKLGtWHDS.KRTGcPGWsVhWDGWFRLQDMlEGYhlhKSL.......Dp-.....................	0	11	26	31
+4714	PF00576	Transthyretin		HIUase/Transthyretin family	Bateman A, Percudani R	anon	Bateman A	Domain	This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain.  However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU [2,3].  HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage [4]. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.	25.30	25.30	25.30	25.80	24.70	25.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.54	0.71	-4.18	26	1803	2012-10-02 19:08:27	2003-04-07 12:59:11	16	7	1506	439	545	1303	706	109.50	40	82.21	CHANGED	ssLoTHVLDsupGpPAuulplcL..........a+hs...ssshp.lsostTspDGRh..tsLlsspphtsGhYcLpFcsucYaputGh................ssFh-hlsltFsls-ss..pHYHVPLLLSPauYSTYRG	.............................................s..LosHlLDpspGpPA...........ssVpVpL...............................ch...s........sssh....p..l.s.s...uhTspDGRl............ts..........l.........h.................s...........t..............p.................s..........h..............s.....sG....................t..................Y..+lhF.csucYF...cpp.sh...................psFas..pls......lpFpls...css.......pHYHVPLL.LSP.auYSTYRG..................	0	132	273	418
+4715	PF03896	TRAP_alpha	TRAP-alpha; 	Translocon-associated protein (TRAP), alpha subunit	Finn RD	anon	DOMO:DM07004;	Family	The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane [1].	23.10	23.10	23.10	23.40	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.92	0.70	-5.41	11	349	2009-09-11 14:06:22	2003-04-07 12:59:11	11	8	203	0	190	299	3	225.90	31	89.23	CHANGED	M+.h.plLLLhLLuFPusLl.hutspu.hssA..p-...--Es........-D.lsp---DpA.VE-Dp..t.oEt-E---.....tplpuSPcADTTILFVKs........c-FPAsplVKFLVGFTNKGs.cDFlVESlEASFRYPQDapaYIQNFTA..........LPhNslVpPpcpATF-YSFlPuEsh...............uGRPFGLVIsLNY+DusGNsFQ-AVFNQTVsIsEp--GLDGEThFhYlFLuGLulLllluhaQhLpSppR+Rs....tthVEhGTuups-VDhsWIPpETLspl.....sK....uSP+............pSPRpRptKRuAGsD	....................................................................................................................................................................................................................................................................................t..............tsssts.cshhhFsps...........p.hsusp.schLl.uhpNc..G...p....p.shhVpslp....u...Sh....+....hP.t...D.......a.......phhlQNaTA..........h..h.s.t...V.s..tppuThpYsFhs.sc.h...............t..spsasLsl.sls.Yp.Dh..s.....G..p.h.ap.sss.aNpTVsllE.t.p.su.l.DsEo...lFhY..hh.L.s.u.l..s.l.h.s......lh..hht.........p......h.....h.t..t....h...p+p+.......................h.plE.....h..........G.....T...s......s.....t..p.s........h...D..pWl...Ptcp..l.p.....................................................................................................................................	0	55	83	145
+4716	PF04051	TRAPP	TRAPP_Bet3; 	Transport protein particle (TRAPP) component	Wood V, Finn RD, Mistry J	anon	Pfam-B_9946 (release 7.3) & Pfam-B_6495 (release 8.0)	Family	TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits.  This family contains many TRAPP family proteins.  The Bet3 subunit is one of the better characterised TRAPP proteins and has a dimeric structure [2] with hydrophobic channels.  The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues.  Bet3 is proposed to localise TRAPP to the Golgi [2].	20.70	20.70	20.80	20.70	18.80	20.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.99	0.71	-4.69	84	1130	2009-01-15 18:05:59	2003-04-07 12:59:11	11	22	333	34	772	1043	17	154.70	25	76.72	CHANGED	hFslhauplVs.hhc.............shp-lp.........................................................................ppLcphGaplG......hRLlE..................................chhh+..............................................................tt.tRppchhcshchlspsha+hhauppsss...........................lppspt.....................tpah.lh-p.s.l...............................spal.p.s.....ttht.pL.....................passhhsGll+GuLpshthsspVshpps.h...........h.stsshpI+hph.p	...............................................................................................................................hshhasplVs..hhp......t........sht-lp...................................................................................................ppL-ph.............GaplG......h+LlEphht+..................................................................................................p...tRhpchh-hhchIspshW.ph.has+p..s...c..s.................................lppsp....p...........................spah..lh-pp..l....................................................spal.phs..............p..t.t..tl........................................asshhsGll+GuLpt...l..sht.s.......p.Vshp.s.h..............s..ssh.lcht..h.....................................	0	266	420	622
+4717	PF04956	TrbC		TrbC/VIRB2 family	Moxon SJ, Bateman A	anon	Pfam-B_5261 (release 7.6) & Pfam-B_14627 (release 10.0)	Family	Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure[1]. This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species [2].	28.40	28.40	28.40	28.40	28.30	28.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.14	0.72	-3.99	114	1258	2009-09-11 06:06:03	2003-04-07 12:59:11	8	2	765	0	305	1048	45	96.80	19	86.80	CHANGED	Mp.................hhthhhhhhhshhhhhhhspsAhApss..........sshpsslpslhshlpG.luhsluslsllssGhthhhGphs....hpphhhlllGlslhhuAsplsshl	..........................hhh................hhhh.hhh.hh.h.h.hs..ss.AhApsss................tshpsslpslhs.lpG.luhsluslsllssGh.thhauptp........hppll.h.lllGhs....lh.h.uAsplssh................	0	47	166	228
+4719	PF03743	TrbI		Bacterial conjugation TrbI-like protein 	Finn RD	anon	Pfam-B_776 (release 7.0)	Family	Although not essential for conjugation, the TrbI protein greatly increase the conjugational efficiency [1].	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.83	0.71	-4.80	149	1918	2009-01-15 18:05:59	2003-04-07 12:59:11	9	40	1082	20	412	1681	119	183.10	23	39.41	CHANGED	hhl.tGohIsusLhTulsSsh........PG.l.hspVopsla.ossG....ptlLlspGopllGpY.pus...ls.GpsRlhlhWsRllhP.s.....Gts.lsl...stsusDth.GtuGlpGp.VssHahphauuAhlhollus....ssphh.............sssssssssssh...............hhpsssp.shsphupphlcpshslt.PTlplptGph.lslhVs+Dlsh	....................................................................................................................hlstGohIsssLh.oulsosh.................sG...l.hsplspsla..sssG....phlL.l...sp...Go....plhGph...pus.....ls.u...p.s..R..lhlhapch.l.hs..s.........Ghs..lsl...............stsuss.........h..G...tuG..........lpGp.V....s.s...+h.h.phh...usAh.hhuhlss.hsphh..........................................t...tt..psstsspsth.....................................................................................thtpusup..uhsphup.p...hlcp..sh...sl...Ps.lhlptGpt.lslhlscDl.h.......................................	2	81	230	319
+4720	PF04610	TrbL		TrbL/VirB6 plasmid conjugal transfer protein	Mifsud W, Bateman A	anon	Pfam-B_5275 (release 7.5) & COG3704	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.67	0.70	-4.65	129	1847	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1036	0	437	1663	116	208.00	14	43.80	CHANGED	lslhlhlhGhhhh...hst.hptsh.tchltchltlul.hshlhts.....hs...sasshlhsshss.hstth...uu.........sstsssshtthspl..h.stuhshsptl.........hppssshh............hhhhhhth...lhhlsshlhhhls....uh.lhlshlthtllhhhGPlhlshhla.shTpphhppWlsplluhulhllllsllhul....shshhs.shhssh...................ssspsslppshshllhuls...hhhlhhtsPslA....uul	.....................................................................................................................................hl.hhh.h.sh.hh.....ht.....t.....sh....phh.ht.....hhh.hsh...hhhhh.s.......hs.........h....phl.h....p.h...t.htt.h...........st..............................ts.h...sth.........h...thsht..h..ht.h..................................................hpphsth.........................hhhhh.hhh.....lhh..l.sh.h....l.hhhhh........shhh.llshl........thhlhh.hh...u.Plhlsh..hh.a.shT.+p.h..hp..s.alp..tllu..h...sl...p...h.hllslllu.l.........hh.shhs..phhsth........................................tts.h....tt....h..h.....hh...hhslh.....hhhlhh.h.s.hht....................................................................................	1	96	236	316
+4721	PF03461	TRCF		TRCF domain	Dlakic M	anon	Dlakic M	Domain	\N	25.00	25.00	26.00	25.20	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.01	0.72	-4.05	117	4305	2009-09-10 17:08:24	2003-04-07 12:59:11	10	10	4219	3	926	3507	1246	100.20	30	8.89	CHANGED	cL....slsAhlP-sYls-.p......pRlplY++luss....pspc-lpclppELhDRFGshPpplpsLlplscl+hhApphslpplptpppp.l....hlpa.sppsshshpthhhhhp	.......pLplsAhlP--YI.s.D.p......pRlphYKRluss.............csp..p....-lc-lpsELlDRFG.......hP.....c....sppLLplspl+hhApphGlpc.l....c.....tpsps...l.....tlpF..sppsphp.........hh..............................	0	316	613	786
+4722	PF03546	Treacle	treacle; 	Treacher Collins syndrome protein Treacle	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.10	21.10	21.70	21.50	19.50	20.60	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.24	0.70	-5.71	4	216	2009-09-11 10:35:01	2003-04-07 12:59:11	9	8	25	0	59	246	0	175.30	26	51.50	CHANGED	sPAPPGKsGPuAsQApstKPEEDS-SSSE.-SDSE-EsPAshsssQsKPSGKsPQVKuASssupps..spKGsPPVsPGKAGPsAsQA......tc.pspSSpcppssptEsPsAh..TpS.spsKP.tpsSQVRssSsss.Gs.........PtKstssA..sQsGKp.EDS-SSSEEESDS-s.....suuPAQAKSSGKl.Qh+sASGPsKtPPQKAGPsATQVKs-+uc-DSESSEEpSDSE-..EAPsAhosAQAKsAlKhsQhKASP+KGTPhossuA+ssPVpVGTsAPpKAuAVoSPssuSSPAlA+GTQ+PsEDSSSSEESESEEE.TAPAsstGQuKSlGKGLpVKAASsssKts.GQGTAPs.PGKsGPuss.VKAEsQED.SESSEE-SsS...EEAAAsPAQVKTuVKpPQuKANsusTRsssAKushSAPGKsVsAssQhK.tSPAKsKPPsRs.QsSsVSsRGQsSVPAVGKAsAsAAQAQsGPVtsspEDSE.SSEEESDSEt..EsPsQsKPSGKTPQVRsASAPuKt	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	6	6	11
+4723	PF00088	Trefoil	trefoil; 	Trefoil (P-type) domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	21.00	21.00	21.10	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.01	0.72	-4.32	86	900	2009-01-15 18:05:59	2003-04-07 12:59:11	13	54	128	38	475	805	8	43.30	33	8.06	CHANGED	pCs.l.......ssppRlsCGhss...IopspCp.p+GCCacs...........p..........sssaCFas	......................C...h...ssppRhsCusss......lo...p..ppCp..s........+G......CCass.....................t.................ssPhCaas.............	0	154	186	297
+4724	PF01204	Trehalase		Trehalase	Finn RD, Bateman A, Wood V, Studholme DJ, Moxon SJ	anon	Prosite	Family	Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with Pfam:PF07492 in fungi.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.72	0.70	-5.86	20	2673	2012-10-03 02:33:51	2003-04-07 12:59:11	13	12	1263	20	654	2119	179	396.50	30	72.24	CHANGED	+hasDpKpFlDhshhs-..ssplhpthpsph.cs.st..sspsLppalc-sFpts.t.h............th.sPtstp-p.c.ah.h..pcssLRh.sppLsphWss..LsRplptpstths.thollshPp.........PaVVPGGRFpElYYWDSYahhLGLLtSsph-............hu+uMl-NFhahIc+YG+I.NGsRoYYLsRSQPPhLohMlhthhc+h..........ss-thh+chLsslccEasaWhs.......ss+hssVsshu..sapLstYhsss-TPRsESht.DhthAp+hs......-tscs.hYp-L+uuAtSGaDaSoRWlc-..Gps.s.hsslpTssllPVDLNulLa+hEpsIA.....hFssthsp.............hpsushacppAcpR+puI-paLWs--sGhahDYDhppp............cpsshhoAoshaPLWsshusscp....st.hsspslsphppsuhLp...suGlusoslc...oucQWDaPNGWAPhQhlshpGLp+YG....cplAccLAhRWLtpsppuascp....GtllEKYDVsp.......suchG..GGGGEYssQ-GFGWoNGVhlhhLchas	.................................................................................................................................................................................................................................h.......................................................l..hht..h...................................................................t.t....hp.....l..........h.....hh+..........................t.......................................p....h....st....................................sall.P....G....G..R..F.pE........h.Y....h...WDoYh.....hh................GLh.s.......t...h...p............hh..tshhtNhh..l..pthGh...l......Nu....sR.YY.....tRSQPPhh..uhMV..hhpt........................s.t.hh....p....p....hh...s....t.l....tt....a.s.a...Wht.................................s.t.....tp.h.s....t..h..................t..........h......Ls.p......Yhs...s..........-.......ss.p.s..-..S..h..h.sh..tsAt.p.s.........................ps.sthatp.l...c..s.s....t.ts..u......aD....h....o......S.R..W......h...tp.....s.............................................h...s...o.....l...............ps..........s......pl...l.......s.........l...D..L..N.....uh.hap.....cphlA.............phsthh..Gc..............................................tpps.ttacphApthp.ps.lp...phhWspp.pGh.ah.......D.achppc.....................................p.....p..p...h..h.s...s....s...u....h.hP..L.as.sh....Aspp..p......................s..p...h...h...s.p...h..t..p...t...p..h.lt.............PuGls.so...php........s.sp.Q.....W..D....t...Ps....u.....W....s.....P.h.pa..hu.....lpGh.p.p.YG...............................pphA.........c.l....utp....alpp........spp..s...a..................t................p..............p..................t..............t.lh.................E..KYs.st.....................................ss..t.....ss.hch.......p.....p...GF.GWoNushh.hlt...s......................................................................................................	0	245	385	556
+4725	PF02358	Trehalose_PPase		Trehalose-phosphatase	Bashton M, Bateman A	anon	Pfam-B_762 (release 5.2)	Family	This family consist of trehalose-phosphatases EC:3.1.3.12 these enzyme catalyse the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate.  The aligned region is present in  trehalose-phosphatases and comprises the entire length of the protein it is also found in the C-terminus of trehalose-6-phosphate synthase  EC:2.4.1.15 adjacent to the trehalose-6-phosphate synthase domain - Pfam:PF00982.  It would appear that the two equivalent genes in the  E. coli otsBA operon [2] otsA the trehalose-6-phosphate synthase and otsB trehalose-phosphatase (this family) have undergone gene fusion in most eukaryotes e.g. Swiss:P31688 and Swiss:P93653. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance [1].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.31	0.70	-5.45	24	2499	2012-10-03 04:19:28	2003-04-07 12:59:11	11	26	1614	1	1046	2316	209	215.20	27	42.78	CHANGED	hhDaDGTLsslspp.s.sshssschhssLppLuucss.hlhllSGRshp....phhsps.slsluupHGh.lRhssuppaps...................s.stshshhcplttlhpphscphsGuhlEpKcsulshHYRpAssc....pspphhpplcsshpsp.slclppG+pllElRPshss.KGtslctllpphs.t..............s..sphslslGDDhT.DEDhFcslppt.......tshshclhsss..stpsopAthhlpsss	......................................................................................................................................................hhDaDGTL........s......sls....sp...P......p.t.....s..h.s.s.s...p..hhpsLpp.L.........us.ps...ss..t...lullSGRshsp........l........c........t..h.....s...........t........h..............p......l....s....lA.GpHG.h-h....+..t.....s........s.....u.....p.....p..hhs.......................................................................................................t.h....s.h...s....h....h...p...p....l.t......t.....L...p....p..h........h........t......p....h...s.....G..sh.....l..E........p..K.t.hul...sh...HY...Rp......A..s........p..c..................t...t.p.....tl..h......pt...h....p.p..h..h..t.....p.h.....t.l.p......lp..t..G..+....p.....l.lE......l..+..Pt........sss..KGp....Al....ptlhpp.hsht.............................................sp.hslhlGD.DhT..DEsuFtslpph........................sh...s.h.h...lhtst...........o.A........s..............................................................................................................................	0	327	667	904
+4726	PF03973	Triabin		Triabin	Finn RD	anon	Pfam-B_20829 (release 7.1)	Family	Triabin is a serine-protease inhibitor.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.90	0.71	-4.55	4	329	2012-10-03 08:47:39	2003-04-07 12:59:11	8	4	13	3	2	409	1	140.20	25	76.19	CHANGED	Ap....s.hMP.Gs.p..tchhssFchpcFFs.scWYlTHucsss+PplCpcapsous.c.........clpas...htS-VpCpsspVpGtcG..aSFpCcsss.....pcFpu.hoVluTDYcNYALlhRCspa.pSshcDsaLVhpRpKpus.Puulpop	...............................................................................................ttt.................tshpsFsspcF....ap..u......pW...Y....VT..H....s....p.....p...s.....o....p.....s..s..l..C..+..p..a.p..s.s.pp...sup..h.hs....hp..a..s.h..s..t....ttt......p.......l....pC..p..s..p....t.............p..p...t....p....pt......h....sFsC........p.....s....ss...........................hph.....p..h.....h.s.llsTDYssYAlhY..RCsph....s...s...t........h.....p........D........N.h.LlLpRp.t..s.t............t.........................	0	1	2	2
+4727	PF02080	TrkA_C	TrkA;TrkA-C; 	TrkA-C domain	Mian N, Bateman A	anon	IPR000309	Domain	This domain is often found next to the Pfam:PF02254 domain.  The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1].  The domain is predicted to adopt an all beta structure [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.04	0.72	-4.38	181	18298	2009-09-12 01:06:25	2003-04-07 12:59:11	16	80	4247	44	3835	11843	3990	69.60	20	21.79	CHANGED	lhphplst.ss..lsG.cslp-.ht....ltpt.....shhllul..p....Rs......tthhhPss.sthlpsGDhlhlhuptps.lpp..htphhs	........................h...h.l.t.ss..hsG.+slp-..lp.........ltpt.........sshlsul....h...................Rs..............sphhh...Ps...s...sshlp.tGDhlh..l..h.ustpp..lpp.ltp...............................	0	1256	2566	3307
+4728	PF02254	TrkA_N	KTN;TrkA-N; 	TrkA-N domain	Bateman A	anon	Pfam-B_289 (Release 5.3)	Domain	This domain is found in a wide variety of proteins. These protein include potassium channels Swiss:P31069, phosphoesterases Swiss:Q59027, and various other transporters.  This domain binds to NAD.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.38	0.71	-4.09	219	14934	2012-10-10 17:06:42	2003-04-07 12:59:11	13	58	4445	85	3537	12367	5545	116.30	21	31.04	CHANGED	llllG.hGchGttlscpLtp.s.p...................llll-pst..pp..lpph..p.pph...h.........slh.GDuocppsLpps.slppsc..sllss...hs.......s-....psslhsshhs.+ph.st..hp...ll..A+spstpp.....tchl.pp..hG.....s..ctllsP	..........................................................hlllG..h.G.p.h.G..t.tlucp...Ltp.pt................................slhll....-....p...s..t.......pp.............lp...ph......p..pph......hp.....................slh..G.D..u.s..c.........c....l......L..c.....p...u....u....l........p.......p....s-.........hll..ss...ss...................sc......psshhsshhs..+p...hhst.........hp.........ll....u+s..psspt.........hph...l....pp.......hG.........h...s.hl.................................................................................	0	1086	2338	3026
+4729	PF02386	TrkH		Cation transport protein	Bashton M, Bateman A	anon	Pfam-B_529 (release 5.2)	Family	This family consists of various cation transport proteins (Trk) and  V-type sodium ATP synthase subunit J or translocating ATPase J EC:3.6.1.34. These proteins are involved in active sodium up-take utilising ATP in the process.  TrkH a member of the family Swiss:P76769 from E. coli is a  hydrophobic membrane protein and determines the specificity and kinetics  of cation transport by the TrK system in E. coli [3].	19.60	19.60	20.00	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.98	0.70	-5.88	26	6295	2012-10-03 11:11:44	2003-04-07 12:59:11	11	18	3786	2	1475	4562	3549	309.50	23	66.68	CHANGED	pluttphpuhpphhphlhhhhhhhchlutlhlslhhlhhhthtts..............................h..ha.AhapohSuhssuGhSlpssS.hssFss..shhlphlhshhhlhGu.huFslhhchhhhhh.t...........h..hhhahtsh.hcshh.Llhhuhhslhhhphhssh.................................htthshstplhssaFtssssRTAGFoshDluphssushlhhhlhMaIGussuoTuGGl+ssphthhltsh..........pthhpt..........................................thpstpattcplppphlh....cshhlhlhhhllslspshhL.hhtpss....hhshlFEssSAaGTVGLShGh...............ssshohs......uKlllIhhMlhGRlchlshllhhshhh.	........................................................................................................................................................................................................h.......t.hht.h.h....hh.thhh..phlu.t.hh.hs...h..h...h.l...h..h..h...h..h..h..t.s.............................................................................................ha.p.ulhpuh..Ssh.....ssuGF...s.hh......s......s.......S.....l...h.........ass........h.lphl.lshhlllGG.ls...F...s....l.hh...p..l..h..tt..t.t.............................................h.pha.h+.....s...hphhh....ll.hh...u...h..h..hl.h.h.ht.h.hthh.........................................................................................................s..h..s..h.t...s....h.h.h.s.s.a.h...s.s.s.s.pTuGF.s.o......h......D....h...s.....p.....h....s...........h..s..........h....lh.h.....hhM..................F..IGus..sGST...u...GG...........lKshp.hhllhhhh...............h.h.h.h..p..............................................................................................................th..s..hh.h.....s........+...tl....s....p....c....h..lp........psh.s.h.h.h..h........h........h.h.lh.....h..h........s.......h...h...........h........l..................h..........s.......s........................s....................................h.......shh.hp.s....hS................A.husl......G.......u...h....G..h......................ss..shssh...................uKhllhhhMhhGRlthholllhhh............................................	0	480	956	1266
+4730	PF02005	TRM		N2,N2-dimethylguanosine tRNA methyltransferase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This enzyme EC:2.1.1.32 used S-AdoMet to methylate tRNA. The TRM1 gene of Saccharomyces cerevisiae is necessary for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNAs [1]. The enzyme is found in both eukaryotes and archaebacteria [2]	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.29	0.70	-5.54	10	846	2012-10-10 17:06:42	2003-04-07 12:59:11	11	9	491	7	551	1753	342	314.40	25	78.44	CHANGED	Gcu+lplsct..ho........lsstssVFYNPtMcFNRDLoVsl........LsshspKhh................................................hplLDALSASGIRuIRaA..LEhsslcclaANDlsscAVEhI+cN......spLNsls.......-.hllhNpsDANhlMt...pppctFcsIDLDPFGSPuPFlDoAlpSlccp.GlLsVTATDsAsLCG.saPcsCh+KYs.AhsL+s-hCHEsGLRILlshlsptAAKYc+ulcPLLSaSpDHYhRVFV+l+cGst+uccshcphGalhaC.tC..........hp....cpssGhschp........scCtaCGschpluGPlWlGPL+DccFlschlctscs.....ttph..pc+lhtlLphlc-E..lDsPhaYshspluphlKlssPPhpcllsuLtphGFcsStTHhsPsuIKTsAPhcslh-lh+	...............................................................................................................................................................................................................t.............................t.sFaNsh....t....h.....NR.Dlsh.hs............................t....h..t....p.......................................................................................................................................................................p.hL-uhuu.oGl........RulRas..hE............................h..........p....lh.h..ND..............hs.tu.hp..hptN...................hp..hNt.ht......................................h...p.........DAph...h..h............................p.ac.hlD...lD..P...a..G..o.....s.....ss.al-u.Ahp.s..l.tp....t.Gl.....lhlT.sTDhush...s.u.t..chs.hthY......u......u.................h....p..t...h...pE.....h.................ulRlllt.ltptAsphthhl.Pl..h.uh.h.ca..a..hRlhlclh.pu...t.....s.....c.....t.p.....hhh.C.....C......................................................................................................................................ts....s....s.t.....p....h...h.hGPha.sslts.taltph.ht...t.....................h................ph..t.hlph.h....p..........E.......t................s.h.aa.p..p.phsph...ht.h.t......h...hhtt..l.p.GapsohoHht..u.l+TsAs.t.hhth.........................................................................	0	165	299	437
+4731	PF00133	tRNA-synt_1		tRNA synthetases class I (I, L, M and V)	Sonnhammer ELL	anon	Prosite	Family	Other tRNA synthetase sub-families are too dissimilar to be included.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	601	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-13.17	0.70	-6.52	15	21195	2012-10-02 18:00:56	2003-04-07 12:59:11	17	120	5058	69	6103	31264	24036	374.40	23	54.93	CHANGED	shhphWpctsh.FctshptsKs.pts..FslhssPP.sTGplHhGHALspoLpDhllRhppMpGass.ahPGaDptGlssptpVE+KlutcptpshhchGpEcFhscshcattEassph+sphp+LGhhlDas+-hhTh-.phppuVhclFscLaccGLlYRGp+lVsWsssspTALS-hEV..pYKDsc................ushhalsasl......s-ups........plllhTTpP.Tl.ussAlAVpP-........................................-.+hpcLlGpphphPF.......hsRchPllsD.-aVch-tGTGsV+hsPAHs.sDYplGp+asL.....chlNsls-sGshs-ss..................scapGhchFcAcKtllcpLpEpGlLlchcshpHShPaC.RossPl.hhhosQWFV+hcs.......Lscsulcslc....clpaVPcp.tEpcahsWlcNhpDWCISRQhaWGp.IPsWhsc-ssElas....h.ph.tsp.ppcsppshhth.hhchl............phcpssDVLDsWFsSG.hPauslsaP.s.sst-acphaPsDhllpGhD.hhhWhtphlhhuhthpGps......PaKpVlsHGllhDupG+KMSKSlGNslDPh-llc.....................................paGADALRhaLh.sossupDlphS	..............................................................................................................................t..........................................................................................................................................................................................t..t.p..............-....t...................t...........................................u..c....u...........hs...h......................................................................................................................................................................................................................................................................................................................................................................................................................................................u...........t..h................................h.......................................o...................................................................................h................t..h............t............................hs...................sh........p..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................DWslSR...Qh.h....WGh..lP........h........h........h............t.....p..................t.................................................................................................................................................................................................................................................................................................h..............p........-.h...h.....D.....s....a.....h...........p.........S...........s........h...............h............t...........h.......h...........t.............................................................................................t...............................................h......................p...........................................h..........P........s...s......h....h.....h.t.....G...-..............h.......h....h......a......h...................h........h............s......h...............h.........t..p..........................................P...a...p..........p...l...h...........p...G...h...h.....h.....s......t.........t.........t.......p........K...M.SKS.....h...sN.s..l.s..P....p...h...h.p............................................................................................................................p.h.G..s..D.....hhRhh.h....s.............................................................................................................................................................................................................	2	2043	3764	5105
+4732	PF00749	tRNA-synt_1c		tRNA synthetases class I (E and Q), catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_350 (release 2.1)	Domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	19.80	19.80	19.80	19.80	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.86	0.70	-5.77	18	10836	2012-10-02 18:00:56	2003-04-07 12:59:11	16	90	5178	51	2955	8426	5158	287.60	31	62.06	CHANGED	cV+TRFsPpPoGYLHIGpA+sALhNahaA+pasGphllRh-DTssc+pp.EhtcuIh-slcWLGlchp..........tshhpS-+a-thhcastcLIccGhAYhsasosEcLcphRcp.........phs..tps+hsccsLpLa.E-hpptptpstttslRhKlshpus.hshcD.Vthclphss.........cchshsKhcshPTYcFssslsDtl.pITHslRspEahsssspahhlhcAluht..ssat+.hhhlNhssphLSKRKhshh..hphhcshs....shlshLt+hGaos.....puhcEhhstptlhcph.hsh.scuhttFspccLph	.......................................................lhsRFAPSPo..G....hLHlG.....ps+o.AL.hsah....h.A........+................p........h......s....G........p....h.........l......L..........R....lEDTD...t......R......p..s.........c..hhc..................s...............Ihcslc.W.......L..GlcWD...............................................ttshh.Q.Sc.R..h..-..h..Ypphhp...pL....l.p.........p.G........hA....YhC....h....so.t.E...c..l.ct...h..Rtt...........................sts.....................t......s...p......Y.......s.....t......c......s..h......p..h....h.............t......p......h.....t....t....t....t....h....t....s.t....t.s....s.lRh.........+......h.......s....................s..........s.........s........h.........t...h..........c.......D................l............t............G...........c...........l.......p..h.....s..s..t.................................h..c..Dh.l......l.......t.+.......t....c..........G....h....P.........s........YshusslDDth.s..ITHllRGp-als.s....s.s...pp..hh..........l..........h...c....s.....l...............u...............h..................t..................s.......P..........................a.t.H.h.s.h...h...l....s.......s.................t.....p...+LSKRc..........t...............s..........h..............................................................t.........................h.c...ths.........sh.l.s.h.l.t.h.h.G..as.......................t..u...p..p......hhp......h...th.............hp........t......tt.thh..pcL...........................................................	1	979	1835	2473
+4733	PF03950	tRNA-synt_1c_C		tRNA synthetases class I (E and Q), anti-codon binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_350 (release 2.1)	Domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	21.00	21.00	23.00	21.50	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.49	0.71	-4.59	111	2972	2009-01-15 18:05:59	2003-04-07 12:59:11	13	80	2452	17	1073	2415	678	183.90	39	29.60	CHANGED	AsRhhsVh...cPlcls.lss...h.....s........t..phchshHPpp.schGpRplsau..p...plaI-psD...........h.pcLt..G.ppVRL+t.hhslcs.pcl..p..sGplhp..l.sphc..spohtts......h.Kscu.hlHWVus....ppu.lss.phh.Y-pL...hp.........p.t..........thl......lNPcShthh...puhsEssl...tshphssh...hQFERhGYaplD	...............................APRtMAVl.....cPlKll..IpN..a......................sts.............psEhlph.ssHP............p...p.....s............-...h.G.....s....Rp.lPFo..p.....ElaI-+sDFhEp............................................................ssKpatRL..s.G..pEVR.L+s.u.Y.l.I.c..............s..pc...l..........KDs....s.Gslsp.........lhsoYD.....s.-.ohutss........................psRKVKG..sIHWVSu...............scu....lss...ElRLYD+.L.Fs...............................s.p.Psst.....................chl.....lNPc..SL..hhh....ppuhsEP.u.l.............ts.s...t......s.t.ct.............aQFER.GYFssD.........................................	0	358	646	899
+4734	PF00750	tRNA-synt_1d		tRNA synthetases class I (R)	Bateman A	anon	Pfam-B_1276 (release 2.1)	Family	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only arginyl tRNA synthetase.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.18	0.70	-5.63	9	5698	2012-10-02 18:00:56	2003-04-07 12:59:11	14	23	4847	14	1682	4669	4137	317.60	27	59.58	CHANGED	hlsslLspstph..stthpppcVll-FsSsNsst.hHlGHlR.shlGDuluRLhEhhGasVlRt.alsDaGsQhshhhspL.pttptphosp..ltphpshYttshhch.s-El.......ht.cthphlshLputspp....apphhsp.lh-hh+pphpchhsshDVhhhE....uE..hhpsphschlpcL+cpGhlhEpDGAhhlhssta....G-shsh.lllKSDGshsYhssDlAhhhp+h.pcthDhhlYhlsscpcsahtphaAAspthG.asPc.ssclhtls.hVsLscDtc..+hppRuGssVpLsDLL-.............................uIGlsAs+Yu.lppspsosh.hDh	..............................................................................h....hhtt.ttth..........t.....s.ps.p.pl.h.l-asSsNsst..s...hHlGHhRusllGDulspllc....hhG.a.p.V.h..............+t.alsD..............hG.....sQ.h.......................s..h..L...h.....h..........u.........h.............p......................t..........h..............h.......p.......c...............t........h............h..................................t.....................................l.......s...........t.........h...............t...........p.................h........Y....h......t...t...........p...........h............t................................t...........c.................t...............................................................................................................................h...........t...........p...............p...................u...p......p............h..h...h.................p.h.........p.....s.s.c..tp..............................hp.ph.h...p....p........h...h....ch.............h....p....p....h....p...p....h.....h....s....c....h....sl....h..h.pc.................uc....h..h.....s....s.....t......l....t......p....s.l..p.t.L..cp.p.....G.....h.........h.h...............E...............p............-..........G..........A......h...........h.......l.......p.h..s.....p.a...........................G.c.s..h...s..h......l..lh.K.s...............D......G......sh.hYhs.s.............D..lAhth..+h.............p....h....t...h..c...c..hl.hlhu..scpp.......tahtplhs....s........hct....h........G.....a...........s..................p.....sh....p...l.........h.l....s..........hhh.............h..........h.............c......s...Gc......................thpsR.p..Gs.sl..pL..c-l...l.-E.s........h.p...t......s....h..........h...............................................................................................l.uhsu....lha......lp.ph.pth.Fp........................................................................................................	0	587	1058	1400
+4735	PF01406	tRNA-synt_1e		tRNA synthetases class I (C) catalytic domain	Howe K, Bateman A	anon	Swissprot	Family	This family includes only cysteinyl tRNA synthetases.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-12.00	0.70	-5.30	11	5726	2012-10-02 18:00:56	2003-04-07 12:59:11	14	22	4818	10	1568	11552	7784	301.80	46	64.24	CHANGED	.hsslcptpVshYlCGsTVYDhsHlGHuRshlsFDllRRhLph.hGY-VpaVpNlTDIDDKIIp+Atpptpo..................................................................................................................hpplscpaIpsapcDhcALNVL.PshcPRsT-alscIl-hlppLlc+GaAYsus......GDVYFcVsshcpYGpLSspsl-pLctsspsts.......ttK+sshDFsLWKuuKsGE....suWsSPWG+GRPGWHIECSsMsschLG.....splDIHuGGhDLhFPHHENElAQSpAhas.tphspYWhHsGalpl-sEKMSKSLGNFlpl+DhLppa-schLRahhhssHYRs.L-aoEphlppAps	....................................................................................................................PlpsscV.pMYVC..G.sT..VY...s..h..s..HlGp.A.R.........s.h.l.sFDl.lpRa...Lch....hG.Y.c..V...........p....YVpN....l.T..D.........l................D..........D...K.....I.I.....p+..Ap..cp......u.........s.........................................................................................................................................................................................ht..p..l..s.c.+.a.l.p..t...apc..DhsA.....L.s..l.h............P......s...........h....c........P.....R........A...T....c....a..l.......s.......-..h..I..p....hl.c....p......L.l.c.+GaA..Ytus............................GDVY.F.....c.....l.....p.....p.........h...............t.......s.......Y.........G.....p..L.....S...t...........p..s.l..-....-.....l.p..s..G.u.c.s..css..................................p.pK+s.PhDFsLW.K.s.......u....K............s...G....E.....................su...W...s..........S.....P.........W........G.............p............GRPGW...HIECSAMup..chL.G.................s.p....hD..IHGGGtDLhFP..H..H....E.......NEI.AQ.....S......c.............u..........s.............p.................s......p................p.........a..........s....p......Y...W....h...H....s...G..h..l..p..l.......c....s..........E.................KMSKS.....L.GNFhT.......l.......+-.l........L................c................p................a.....s........s..............p................s......lR.aa.h.l..s..s..H.Y..R..s..slsaS.c.csLppA..t.........................................................................................................................................................................................................................................................................................................................................................................................................	2	550	1024	1339
+4736	PF01921	tRNA-synt_1f		tRNA synthetases class I (K)	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes only lysyl tRNA synthetases from prokaryotes.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.25	0.70	-5.78	39	631	2012-10-02 18:00:56	2003-04-07 12:59:11	13	4	615	2	222	4907	4602	353.70	38	66.72	CHANGED	ttWs.p.Accll.cRhpt.....s....phlhpTGhuPSGhsHIGsFt.EVlpsshVt+Ahcph.utp......s+llhhuDDhDsLRKVPc...NlPsp..hppaLGpPLoplPDPa.Gs.ppSaucHhpt.hpchL-phGh.-hEahSuo-hYpuGhasctlhhsLcp....h-cIhcIl..hhscc....hpts...........................a.PahPlCscsG+lhps.lhshc.ptsplpY.s............csGcphpsslpsGt.........sKLpW+lDWuhRWtuLuVcaE.hGKDhts....ShshuscIs.clhGtcsPhshsYEhhh.c...ssp......KhSpSKGsslolc-WLchusPEsLpahhhp.cPppthclphc.sl.+hlDEY.ph.cta..........ppstppphtsslaclppsp	...............................................................................................................................................................tWs.c.Accll...c+.tt.........tp..............hlhp.oGhuPSGhsHIGsFt.EVhpsshVt+Ahcpl..upc.......oRhIhhuDDhDs...hRKVPc.............Nl.....P...s.p..th...........lt.pals.hPLoplPDP............a...G......s....apSaucH.pshlpphL-pFGh....-h.EFhS.uo-hY+SG..tacptlhpsLc+..h-cIhclhh.hh....sc-.....cpts.........................................................................Y.Pa.hPlCscsG+lhp.s....s.lp..phDs.pssTlsYcs.........................csGppt...plsl.s.s.Gp.........sKLpWKsD...W...s.M..R.Wsshs..VD..aE....h..G..KDHts....Shs....l.u.....scIs...c..IhGs..c.s.P.....t...h..s....Y....E...h..h...h...c...ssp.........KlSpS+GN.ulolc-hL......c.h.s..s....s.Es........Lt.h.h.h.h.p.......+...P.p..p..A.h.+.l...h......FD................s.I...s...+.s...h...D...E.Y.phhptYh...........ppphcpphtp.saclp...s.......................................................................	1	67	145	176
+4737	PF00152	tRNA-synt_2		tRNA synthetases class II (D, K and N) 	Bateman A, Sonnhammer ELL	anon	Prosite	Family	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null --hand HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.02	0.70	-5.67	107	16099	2012-10-02 14:22:40	2003-04-07 12:59:11	15	73	4974	111	4475	12333	7486	357.10	28	69.99	CHANGED	sc-hRLcaRaLDLRpsphpp.tlphRsclhpslRpahscp.GFlElETPhLspussEG......ARsFlVss..............tpaau.....LsQSPQLaKQlLhluG.h.-RhapIu+sFRsE-h...+scRps.EFTplDhEh..uFsstc-.lhplsEpllpplhc.ph.h.......................slcls..........F.Rloap-Ahcpauu-c.sDh+h.th....ph.p.htph............t.thphht..............................................................................................t....htphhstlhtch.......scc........tlh....t.pthphhalsDaPhh......p......................+PFst..spp...ps.......................shucsaDlllsG..hEluuGuhRlpc.chQpphFcthshs.....tcp..thFsahLcAhca.GsPPHGGlAlGlDRLlMllsstpsIR-VIsFP+spp	.........................................................................................................................................................................................................................................................................................................................................-h+hc.RaLD.L.h.p.s..p.t...............t...s....hphRupl..hpslRca............hs...pp...G.......Fl-lE.TP......h.......l.......s.......t.....s...s.....s....pu..........tA+sFhsp.....................................p.hhs......hhLt.........S....P..p.........L.a.....hc......h........L..h....s..u.G......h....-.......+..l..apl.......u......+.sF..R...sE...sh..........s..s..R.HssE..FT..........l-.h..h......u.....a..h.c..h...................p.............-.....lhs..l.s..E..........s..hl..ppl.hp.pl..h..........................................................................thphs..............ts..F.+....lo...a.p-.A....hcp.....h...ts......pp..............c.hc.............th..t..htth..........tth.thph......................................................................................................................................................................................................................................hGtlhsph........hcc.......lh.........-pp.hhpPsalhc.aPht.......h.......................................................pPhst.....ps....ps.s.........................................................................................thsptaD.l.hl.sG............hEl.us.G.pclpcs..c..Q..p...p.pFct......s.hs....................................p--....t............h....t.alc.A.h.cY..G.....h.P.Pp.u..GhulGlDRLlMll...ss....t....p...s.....IR-VIhFPph.......................................................................................................................................................................................................................	0	1514	2790	3758
+4738	PF02081	TrpBP		Tryptophan RNA-binding attenuator protein	Mian N, Bateman A	anon	IPR000824	Domain	\N	20.50	20.50	24.40	25.60	18.10	17.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.55	0.72	-4.55	10	142	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	138	252	55	115	0	73.50	64	97.61	CHANGED	Mpssp..suDalVIKAlEsGVNVIGLTRGoDTKFHHSEKLDKGEVMIAQFTEHTSAIKlRG+AhItTsaGplcSEuK	......h....tsuDYlVIKAlEsGVsVIGLTRGpDT+FHHoEKLDKGEVhIAQFTEHTSAIKlRG+AhI.TpaGplcS-.......	0	27	44	48
+4739	PF00587	tRNA-synt_2b		tRNA synthetase class II core domain (G, H, P, S and T)	Bateman A	anon	MRC-LMB Genome group	Domain	Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.26	0.71	-4.68	112	18502	2012-10-02 14:22:40	2003-04-07 12:59:11	20	111	4989	173	5461	19073	11934	180.70	25	33.50	CHANGED	lpptlhphhpchhp...p.GapcltsPhlhppclhpt.oGc.tphhcc...hap...h...........pcttt........c............p......h..........................................................................................................hLpPpsp.slsthatpphhp.hpp..LPl+hhthush.aRpEh....psp.GlhRhRpFpps-hhhass.s.pp..............................................s.pthtchlphhpplh.pp...lGl.........saclh.sspsshst.tppphshcsah.sp	...................................................................................................................................................................................................................................................................................................................ctlpphhhcphp.....ct.G......a.p..ElhsPh.lh....s.t.....c.lapt...o......G..+...h...s..p...a...s..-s.....h...ap....h..................p.s..tp..................................c............p......h...............................................................................................................................................................................................hLtPp...sp....sh.ss..h........ac.s..........p.l...p.............S....................h..+............c.......L...P....l.....p.......hsp.h...u...s......s.a.....RsEh.......pstpGlh..R.....sR..p.F.p.p.t.......-.ta.h.F..sp..s..-p..........................................................................................................hp.c.php.p..h.h..s.h.hp.clh...pp......h..Gl...............sa.+.h..h.h.ts.p..s.sh.u.h....s.u.scpach.ph.....t...........................................................................................................................................................	1	1884	3455	4605
+4740	PF01411	tRNA-synt_2c		tRNA synthetases class II (A)	Howe K	anon	swissprot	Family	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.	19.50	19.50	19.60	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-12.92	0.70	-6.22	25	6692	2012-10-02 14:22:40	2003-04-07 12:59:11	14	24	5160	30	1902	5657	5079	441.50	35	60.86	CHANGED	ElRppFLcFFc.c+G...HphlsSusllPc.sDPoLLFsNAGMspFKslFLGtt.....psshsRAssoQ+CIRsGGKHNDL-NVGhTuRHHTFFEMLGNFSFG.....DYFKcEAItaAWElLT..ph.....asls.-+LalTVapsD-........EAhslWpchs.lPcpRIl+hstc.......DNFW.....pMGDs.............GPCGPCSEIaYD+G.chsst.sus.sp....-ssRalEIWNLVFhQaNRps......cGshpsLPc+slDTGMGLERlsuVLQshpsNa-sDlFhslhpthpplouh...s........spsthphuaRVIADHlRulsFhluDGllPuNpGRGYVLRRILRRAlRau.+pLGhcps.FhtcLVssllchhGssaPELccptshlpcllcpEEppFt+TLcRGhpLlcchlpphpp..spslsG-suF+LYDTYGFPlDLTp-lAcE+GlsVDhpuF-pshpc.p+cco+..pstpstt.....hthshpsltcltss......s-FhtYsph.............pspuplhulhp.sschlspltt.Gppsh........llL.DpTsFYAEuGGQluDpG...hlpsss....scFpVpssQchs.uhllHhGpl..ppGs..lplGDpVpuplDppR	......................................................................plRphalpaFt.p..p.s....H.h..............Sssll.P..sDsoLLahNuGhs........h.K.hF.G.................................h.........R..hsssQ+sl....Rss....Dl-sV.GhT.s..RH..pTFFEM..LGNFSh.G.................DY..F.K........c....-AItaAWEhLT.....ph.....hths.-+LasTha.....t.....Dp........................EAhplWtp.............................l...........stp+Ih.h.......p....................DNFW........phGt..............G.PCGP.soEIaaD..+..G......t..hh..s...t...........s....t........t....................-ss..RalElWNl.VF.Q....asc..pt......................................ps..p..h.p.L.P.p..s.lDTG.MGLE..Rls.........ul.........hQ.........t.........hp..........sNa-hDla.hsl..lpthtph.ss....................................................t.t.ts.huh+VlADHlRshsahluD..G..shPuNpGRGYVLRRllRRA.....h....Rau......p......h...L......G............h..............p........t........s......a.....h.hcLl.ss.......l....hp...........h..........t....t......h..a..s..-lh.p.........p..t..t......h.....ltph...lp...tEEppFh..c..........T...............LppGh......tl....hpp............ltp..ht...........................tphls.Gp..sFc.L...a..DT..YGFPl....-LTt-h......h.p.-............t.s..........h..p..lD.t...sFpt.tMtt.Q+.......pcu+...tstt.tt.................t.......t......h.......p...h....t.....................sphhsYp.t...............................p.h.p.u.pl.h.t.l.h.........................p........s.............t..........s........p...t...h.....p........t.....u..p..p..s.h....................ll..L..-p.TPF.YAE..uGGQsuDpG.............hl...t...s..ts........................h...h..t.V...t..D..s..p...+.......h......s...s.......h.......h.h..H.h....s.pl.......t...........u.t........l.....p..hGpt.lphplD............................................................................................................	1	653	1183	1586
+4741	PF01974	tRNA_int_endo		tRNA intron endonuclease, catalytic C-terminal domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.	21.10	21.10	21.30	21.80	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.66	0.72	-4.18	78	852	2012-10-11 20:44:43	2003-04-07 12:59:11	12	20	456	40	569	852	86	86.70	26	27.42	CHANGED	F.h+ahVY+cLRc+.Gahl+sGhK......aGsDFtlY........tttsshsHucalVh............l.lspspth......................shpclhptsRlupuV+KphllAhl.....sppsc.......lsa	..........................hpYhlY+cLRs+.Gahl.p..sGhK............F.GsDal.lY.........ttsPhhhHupa.hVh..................l..h.s.......s.cph..........................................sht.p.lhshsR...lussV+Kphllshl.....p................................	0	178	316	463
+4742	PF02778	tRNA_int_endo_N		tRNA intron endonuclease, N-terminal domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.37	0.72	-4.42	65	347	2012-10-01 20:02:48	2003-04-07 12:59:11	9	7	240	33	209	357	30	66.70	25	25.64	CHANGED	hpuhL.sspVllt.....s.csspp...LacpuaYG+.............hpsphLpLSllEAhYLhp+.Gtlclh....pptchlshcclh	..................................h.h.tt.lhh........t..pp........lhpp...shYGp........................................h.tphLpLSL.EAhaLshp.GpLplh......ptc.lsh.ph...............	0	50	112	158
+4743	PF01746	tRNA_m1G_MT		tRNA (Guanine-1)-methyltransferase	Bashton M, Bateman A	anon	Pfam-B_2049 (release 4.1)	Family	This is a family of tRNA (Guanine-1)-methyltransferases  EC:2.1.1.31. In E.coli K12 this enzyme catalyses the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA [1].	21.50	21.50	22.40	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.96	0.71	-4.70	23	5148	2012-10-01 22:53:19	2003-04-07 12:59:11	16	19	4707	18	1419	3601	2980	190.20	39	74.76	CHANGED	hpph.c+clsplphpshRsasts++phsssphahsuhshhhKhc..h.thp............shpshhlpsps..h.pphh.pl....pp-....cllhLsuchEsh.pclpppt.......hasIGshV.psschss..hhstththh.Glh..st.pL.h-sa.......llttPth....o+shs..lp..pV.-lLLpspc..hpsW..cpulhcshspR.	..................................................................................h.s+AhcpsllplpshshR-asp.s.+.Hp..p.V.D.D.p..PYGGGs.....GM.l..hp....s..p..P..l...hsAlcsh............pt.........................pts+l..Ihh..oPpG....c.hs.Qph.sp-.L.............u.p.p.p............................cL.lhlCG+Y.....E.GlDE...R.lhpt.hss...........pEhSIGDYVLoGGElsA..hshh..DulsR.llPGVL..Gppt.SttpDSFs........................sGLL-hPpY..........................TRPts..acG........hpV.P.-V..L.....lSGsH...t..pIccWR..hcpuLt+Th.+RP.......................................................................	0	488	884	1178
+4744	PF03054	tRNA_Me_trans		tRNA methyl transferase	Griffiths-Jones SR	anon	Pfam-B_823 (release 6.4)	Family	This family represents  tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside  5-methylaminomethyl-2-thiouridine present in the wobble position  of some tRNAs [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.24	0.70	-5.90	21	5331	2012-10-02 18:00:56	2003-04-07 12:59:11	11	13	4511	6	1265	6684	5283	320.80	41	86.58	CHANGED	t+VlVuhSGGVDSSVuAhLL+cQG.apVlGlaMcpasp...t-phs.........tCsutcDhpDAp+lscpLGIPhhhlsatccYhpcVhp.Flc-YppGpTPNPDlhCN+pIKFuhhhchshp......LGsDhlATGHYARlshs........................spstLtcuhDppKDQoYFLsslscctLppllFPLGchp..KspVRplApctuLt...sAcKKDSpGICFlucps...accFLpcaLssp..pGsIlchc.....GpllGcHcG...hahYTIGQR+GLslut....htcPhYVlcKDscsNplaVup...p.tLhpcplhspphsWhs.....thsst..hpsps+hRapp...s.hpsplphhss.tplcVpFcpshpuVoPGQssVhYps-....tsLGuGhI	..........................................+VlVuMSGGVDSSVs.A.h.L..L.p.c...p..............G...Y...c..........V.h.G.l..aM.+......Wcc.................scppt...............................hC...s...u...t...pD...h...t.D...A...pt...V...s.c...p.l.G.I......s.....h.a.sl...s..F.t...p.c..ah-p..V...hphFl.s..E..Y.p.t..G.RTPNP....s....lhC.N..+......c.I..KFp..shL-hAhp.................L..G..AD..h.lATGH..Y.uRht.p..t......................................................sst..h.plh+u....h...D.....s.sK...DQo.YFLhpL.spc..QLt+shFP.lGc..h..p.........Ks...c.....VRc.lA.p.c..............h..............G......Ls......sAc.KK.D........SpsIC..F.Is-p.p............app.FL..p...p...................a....l.....s.....s.....................p.......sG..p.....h.h....sh..-.................................G.chl...G.cH...p...G................lhaaTlGQR.+..G..LG.....Ius....................stcP..ha.Vl.shDh...p..pN..hlhVu.p...........c....t..L.hspt..l..h..s..p..p..lpahs......................p..p.......s.h..cs.psKhR..Y+p....................tsh........s..p...l..................p..........h..........h..........s..........-.........t.................p..............h....pV..h.F...s..-..P.t.....A...lo..P.GQu.sVaY......p......u.-......hsLGGGhI................................................................................................................................................	0	456	838	1088
+4745	PF04558	tRNA_synt_1c_R1		Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1    	Kerrison ND	anon	DOMO:DM04413;	Family	This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli.\	      This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function [1].	25.00	25.00	25.50	25.30	23.70	24.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.84	0.71	-4.72	27	278	2009-01-15 18:05:59	2003-04-07 12:59:11	10	19	200	1	172	258	0	152.70	33	20.99	CHANGED	sss--LhpLFpplGLs-pKu+EhlKNpKlossLpsllppu.sss..sshs+pptsLLasLAo..ph+ssp....hs+pshllphIhsuclKTshQlsAAhcalpspss....shsssch-ctsGV.GV.VT.--lcptVsphlppp.KppIhpc..RYp.hsshhhhscttspL+WAcsp	...............................c.h.pLFttlGLsEpKA+EslKNp.plossLtphlppA.....tts.......sshs+s.....sGsLLYslAo....+l+s..st......+h.shl...lpaIsspKl+Ts.Qls..AAlcYlpspst...tsl-tscF-ctCGV.GVhVTsEpIcpsVpphl..ppp..+tplltp..RY+.hs..hshlh...scs+st...L+WADu.................................	0	70	103	143
+4746	PF04557	tRNA_synt_1c_R2		Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2    	Kerrison ND	anon	DOMO:DM04413;	Family	This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli.\	\	\	  This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function [1].	21.20	21.20	21.20	21.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.24	0.72	-3.29	23	240	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	176	1	146	227	0	84.40	35	11.22	CHANGED	hhKstlDhplLcLLGPKsEtDltKKpKps+.....sptstt.h.......sspspspss-ssscps.hhEthhG-...hHKPGEN.........Ppsh..Lhpc	......................lKsplDhplLcLLGPKsEuDLt.Kt.Kttc.................tphtp...................ttpsss...pssp.ssspst.h.Ephhup....FHKPGENhp...............Ppoh.hLppc.......................................	0	55	82	120
+4747	PF02091	tRNA-synt_2e	tRNA_synt_A;tRNA_synt_2e;	Glycyl-tRNA synthetase alpha subunit	Mian N, Bateman A	anon	IPR002310	Family	\N	20.00	20.00	20.50	20.90	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.97	0.70	-5.30	9	3035	2012-10-02 14:22:40	2003-04-07 12:59:11	10	8	2991	8	663	1810	1805	283.40	66	88.81	CHANGED	FQshIhsLQcaWupQGCllhQPaDhEVGAGThpPsTFLRuLGPEPWpsAYVpPSRRPsDGRYG-NPNRLQ+YaQFQVllKPsP-NIQ-LYLsSL+ALGIDshsHDIRFVEDNWEsPTLGAWGLGWEVWLsGMElTQFTYFQQlGGltCcPVosEITYGLERLAMYlQpl-slaDlhWs-u....lTYG-lFhpsEhEhSsYNFEtAsV-hLFphF-.a-cEAhphlc.s..LPLPAY-hVLKsSHuFNlLDARGsISVTERpRYIhRlRsLARtVActYhptREpLGFPL	...................................................FQplILsLQpYWu........c......QGCsllQPaDhEsGAGThHPhThLRAlGPEP.WsAAYVpPSRRPsDGRYGENPNRLQ+YYQFQVllKPSP-N.IQELYLsSLctLGlDPt.HDIRFVEDNWEsP..TLGAWGLGWEVWLsGMEVTQFTY..FQ..QVGGl-Cc.PV.o...uEITYGLERLAMYlQsVDSVYDL.Ws.-G.........................loYGDlF.+QsE.....hEpSpYNFEhADs-hLhppF-paE+E.....Appl..............L..............c..t.t...................L....s.............LP...AY-hlLKASHoFNLLDARGAISVTERppYIhRIRsLu+sVAcsYhtpRctLGFPh.....................................................................	0	211	416	543
+4748	PF02092	tRNA_synt_2f	tRNA_synt_B; 	Glycyl-tRNA synthetase beta subunit	Mian N, Bateman A	anon	IPR002311	Family	\N	25.30	25.30	25.50	26.10	21.50	25.10	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.58	0.70	-5.96	167	3055	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	2988	0	666	2359	2774	541.00	41	78.66	CHANGED	hLlEIGoEELPuchlpphhppltptlpptLpctpLsa..s.slcsauTPRRLAlhl.pslsppQ.sDtp.Et+GPshphAhstsG.sPT....cAAtGFA+up....Gls.......lcc.Lpht..p.........s.sKu-alhh.ppptpGpsstplLschltphlpsL.shsKtM..RW..G.......s.....t...shcFlRPl+WllsLhssc.....llshpl.......h.G....lpouphopGH.RFht.st..slpl.sssscYhptLcpp.hVlsDhpcR+phItpplpphA.ppt..s...sps.h-..-s..LL-EVssLVEaPsslhGpF-.ccFLp.lPtElLlooM+pHQ+YFslhc.p.sG...........pLhPpFlsVuNhpspc..ptlhpGNE+VlRARLuDApFFacpDp....KpsLpshltcLcpVlFpcpLGolh-KspRlptLAthlA..ptl.............s......s.....s...h.ppspRAAhLsKsDLlTpMVh..EFPELQGlMGphY.Ahts...GE....sptVAtAl....pEHYhPphuuDpLPpo.sGsslAlADKlDTLsGhFulGth.PTGSpDPaALRRuAlGllRIll-pp..hslsLppLlppu.hp.h....tt...............hstps.shpplhsF..hhpRlcshhp..cp.u.....hsh-llpAVlu...ts	........................................................................hLlElGoEELPs+slpshtcphtpphsstLcpstLsa..............s..s..l....p..hauoPRRLAlpVp.sLuppQ.s..Dpp.Eh+GPuhphAh...Ds-G.p...s....o.......KAApGF....sRup.Glo...........l-p...l...chh.p..........................s...cpsEalhhp.tp.ht.Gps.spslL.sshlspslppL.shP..KsMRW....G.................s.....s.....shcFlRPl+tlssLh....uc.c.....l.ls..hpl.......hG........................lpou+so+G..HRFh.......s......s...............t..phsl...s.sA..cpY.phLccp..hVIsDh................pcR+thIhpphcphA.pph........u..............s..ps...s..l..-....-s.......LL-EVsuLVEaPsslhupF-.-cFLp.lPpEsLlhoM+scQ+YFsVhc...p..sG.......................................+Lh.PpFIhVuN...hpscc....pplIpGNEKVlRsRLuDAcFFappDp....................K..........p.....s...L..p..s.....h.l..s+L..p..s..VsFpppLGolt-KspRlptlAshlAppl...................................ss-..sscspRAuhLuKsDLhTsMVh..EFs-LQGlMGtaY.........Apts.........GE.........spsV...AhAl....pEpYhPphAuD.pLPps.....l...usslA...lADKlDTLs.GhFulG.h.PoGopDPaALRRAAlGllR..........Il..........lc.....ps...........h.sls..Lpp.Llppu..hp.hh..ssp..................................................htsspshs-lh-FhhsRh+shhpcp..u.......hshDhlpAVLu.p....................................................	0	207	417	544
+4749	PF00261	Tropomyosin		Tropomyosin	Finn RD	anon	Prosite	Family	\N	35.00	35.00	35.10	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.67	0.70	-5.27	43	1328	2012-10-03 05:16:33	2003-04-07 12:59:11	15	16	401	54	388	1233	5	180.20	54	81.39	CHANGED	KKhpplcs-hDpspEplpcApccL-pp-KptpcAEuEVAuLNRRIQLlEE-L-RupERLssAhpKL-EApKAADES.ERupKVlENRuhpDEE+h-.LEtQLKEAKhlAE-ADRKY-EVARKLsllEsDLERAEERuEhuEuKlsELEEEL+lVuNNLKSLEsucEKuup+E-pYEEpI+.Lop+LKEAEsRAEaAERoVsKLpKplDcLED-LhspKE+YKsls-ELDpThsELsuh	..............................hp.ph-thp.pthtthppp.lc.....tc....cth.p..pA...Eu-VA...uLsRRlp.LlEE-L-.R..upERLsoAhpKLEEA.pKAADES...E..R..uh..KVlEN..Ru.h.pDEE+M-h....EhQLKEAKal.......AE-.....AD+KY-...EVA.....RKLsh.lEs-LERsE-RsEhuE..s+hh-LEEcL+.h.spsLK.uLpst........t-..........c..hsp+E.-pYccpI...+hLsp.+LKEA.....E..sRAEhAE.Rs.VtKL.pKplDcLE...-..p...lhtt+.c.hthpp.h-.sh.-h.......................	0	115	147	252
+4750	PF03301	Trp_dioxygenase		Tryptophan 2,3-dioxygenase	Mifsud W	anon	Pfam-B_4263 (release 6.5)	Family	\N	21.20	21.20	23.40	21.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.12	0.70	-5.33	5	1051	2012-10-01 19:57:26	2003-04-07 12:59:11	8	6	627	72	420	1075	498	187.70	29	87.19	CHANGED	-SsQsGspcsScu.GhsYGDYLpLDKlLoAQ+hlS-.ttp.lHDEHLFIVTHQAaELWFKQIlaELDolR+LLsss+l--s+.hLclhctLcRlV+ILcLLssQaolL-TMTPLDFsDFRcYLoPASGFQSLQFRlLENKLGV+supRl.YNtp.YpssFtss....chLLsoEcEpoLLcLlpuWLERTPGLc.pu.s..FWhKapcSVhchLs-LhAptuscpssEVlp+cLst-YcKscEVhtSlhD.p.H-.hltpGpRhhoacAhpGAhMIhFYRD-PRFppPaQLLptLMDIDoLhTKWRYNHVlhVcRMlGS.KpGTGGSSGYtYLRSTlSDRYKVFlDLFNLSTaL	.....................................................h..................h.Y.tYlthp.llt.Q.....o.....................sEhlFlh.HQ........s.ELah+.hhaEhpthht....ht..........t..t......h....t...............phltRh.hh.p.l.tt...h.tl.l.t.s..hos.pa...th...R.......Ls.uSG....FQShpaR.lE...............h...hG..............t..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	143	259	354
+4751	PF04820	Trp_halogenase		Tryptophan halogenase	Kerrison ND	anon	Pfam-B_2531 (release 7.6)	Family	Tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan.  This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent [1].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	454	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.49	0.70	-5.86	23	1611	2012-10-10 17:06:42	2003-04-07 12:59:11	9	14	630	30	502	3763	1761	272.60	18	79.12	CHANGED	+lVIlGGGTAGWhAAAtLu+th.st..hplTLlES-pIGslGVGE.uTlPsIpp.hpphLGl-Et-FhRtTpuTaKLGIpF.sWtp.............tuccYhHsFGs.hGtshthhsFap.....aWLchpttG.hssshssaslsshsApts+F.uss.ps......htslsYAaHhDAuLaAcaLR+hAcs+.GVpRlEGclssVphcs.sGaVsulphc-....Gchl-uDLFIDCSGFRGLLIppsLpsGacDWScaL.sDRAlAs.stsss....sssPYTc...uhAcpAGWpW+IPLQHRsGN.GaVaSScah.....s--cAhstLhsplsupshtpP.chlRFssGR.............R+psWs+NsVAlGLASGFlEPLESTuIHLlps....ulppLlplFPscshs.Ps.tlscaNcpsshEhEclRDFllLHYpsopRsDoPFWcpsR.phslP-sLpc+lcLFpsp...............uphhpttc-hFtpsSWhpVhhGQGlhPctacPLscshss	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..a.p....h.ptt..hs.....t.h.L.h.p.....u...t...G..sp.h..h.....t....t...h........t......................t.....................t......t...............h..............t....l....h.tp......................t...t...........h....p..s..c..h..hlDsoG.t...u...h.....l.........t..p.............h.....................................................p..........h..p...p..........h.................................t.......s.h....h..h......h....t........................s......t...........................h....s..........t..s...G.........W....W....I.....Ph.....t.......t................................................................................................................................................................................................................................................................................................................t..h.h............h.s.u..hhpP......h.....u....sh....................................h........................................................................................................................................................................................................................................................................................................t.......................................................................................................................................................................................................	1	157	306	427
+4752	PF01371	Trp_repressor		Trp repressor protein	Bateman A	anon	SCOP	Domain	This protein binds to tryptophan and represses transcription of the Trp operon.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.74	0.72	-4.07	19	1612	2012-10-04 14:01:12	2003-04-07 12:59:11	14	4	1574	49	242	835	143	86.80	39	83.21	CHANGED	pphptlh-hlhphtspcpp.thhp.lhT.sEhcuLupRlplsc.LLcppho.RcIppchGsShATIoRsupsLchusssapthLcphh	...........................phpphh-hlhshhsp-pph.hhp.lhTssEh..cuLupR.l.clsc.LL+.tp.ho.+-Icp-hGAuhATI.oRs..s.p.uLch.u.s.s.thcthL-chh............................	0	91	147	201
+4753	PF00290	Trp_syntA	trp_syntA; 	Tryptophan synthase alpha chain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.51	0.70	-5.85	18	4254	2012-10-03 05:58:16	2003-04-07 12:59:11	15	8	3921	94	1062	3690	2893	247.30	35	89.87	CHANGED	Fuphptpsp.suFVPFlsAGDPs..hEsolcllcsL.cuGADllELGlPFSDPlADGPsIQpAshRALsuGhThspsl-hlcchR.phsslPllLhsYaNPlhphGhEp....FhtpstcsGlcGlllsDLPhEEusslhphspctslshlhLluPsTs-pRlcplsctusGFlYlVSphGVTGscs.shssplpphlp+lKpho.shPlhlGFGISss-pspphs.tsADGVllGSAlVchlpp......phcptcpslpcltph...sp..hcsus+	............................................................................................................thptptc.sAh.ls.alssG.DPs..h-pohchlcsL........c....u....G............A.............DhlELGlPFSDPlADGPsIQp..AshRALs..s..G.s..........o..hppsh.c..hlpp....l.R...................p....p.....sph.P..llLMs...........Yh.N...l....hp....h..........Gl-p.....................F.hpcstcs.G.V.cGlllsDlP...h....E...E.u...s......h...t...t.t...s...p...c...t.s...l.s..hIhLssPso.sc...-Rlcplsptu.p...............G.F..lYh.lSh..sGV.TGs......ps....p....h.s.s.s..l.p.ph..ltc.l.+p.h........s......s......h.......PlhlGFGIussppsppht....t...sADGlI.lGSAlVch..lpp..........ph.p.p.........t.........................t..............................................	0	339	685	908
+4754	PF03222	Trp_Tyr_perm		Tryptophan/tyrosine permease family	Mifsud W	anon	Pfam-B_2873 (release 6.5)	Family	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.24	0.70	-5.65	13	4713	2012-10-03 01:44:59	2003-04-07 12:59:11	8	5	1373	0	483	3542	123	382.30	25	94.07	CHANGED	+osphlGGshlIAGTsIGAGMLAlPlssAGshFhsohllLlhsWhhhhtSGLhlLElhpphts.....ssuhsTlucchLG+shpllsslshhFlhYhLhhAYIouuGuILppslsphhh.hshss+sssll.....FsllhusllhhuTp.slDphsplllhuhlluFslshshhlsclcsshLhs.....h..sthhshllsulPlhlsSFGFHusVPSLhpYhsps.l+cl++uIlIGoslsLllYllWplsshGslspspFhtlltpGuslssllpALtthhpSsshthslphFuhhAlsoSFlGVuLGLFDaluDlFKa.pcspsGRhchshlTFlP..................................PLlhulhaPpGFlhAluYAG.lusslassIlPslLsapuRpcpspts.a+VhGGshhllllllhGlllhlsp	..............................................................................h...........l.hGTsI..GAGh.L....hlP..l.s..h..u..u.s.G.h..h.h..s..h.h..h...l..lhs..a..s.hh.h........a.su.h....h.l..h.c..hs..p..sss.............................ssshsslsc..c..a...h....G...+......t......h.s.......h....l.h....s...h.h.......h....h......F.......s....l......a...s....l......s....h.u...Y.......h..........s......u.....s..........u....s......h...........l..........p..........p..........h..........h......s....p...........h....t........h.......s........h......s..........p....h....s...s..hh...........................h.s....l...l...h...u....h...l.....l...h........h....G.......pc.......h....l.......s.....+......h......s......s...h........l..l..h..s....h....l....h......h....h.l.....l....h.......h..h......h..L....l....s......p......h......p.........s...h....Lhs..................h....s..s...s......h...h......h...h.......l...h....h...s.l..P....l....h..l..h.S..F......u.a....p....s.....s....l..s....S....h.......s.........p....h........h......s.....p...c........hc.......+......l....p.....p....s......l......h...h.....u.....o.........h...l.s....L.l...h....a..l...h...a...h...h...u...s..h.h........s.l....s............s...p.............h...h...s..h...ht...p...s.......l..s.s...L..lp..s.h.up..h..hs.....s..........s.....h.....l.p.h..s.s.....s....l..hu.....h..l..A.....lsoS.....F.l......Gl.........h.L..G........l.h...-.......h....l....s....-......L.....h.............p.......h........s.......s....s..................t.........h........u........+...h.......p....o...........h..hl...s..F..l..s..............................................................s.h..h....h....s..l..h.a..P.s..u...h..l....hh.l..uh.uG.....h.............huh...l.h.h.llP.hh..h...hh......t......s....R.p........h.....................................................ap....s......hh.st.h.hh..hhhhhhh...........................................................................................................................................................................................................................................	0	100	201	347
+4755	PF01509	TruB_N		TruB family pseudouridylate synthase (N terminal domain)	Bateman A	anon	Pfam-B_792 (release 4.0)	Family	Members of this family are involved in modifying bases in RNA molecules.  They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA [2].	25.60	25.60	25.80	25.60	25.30	25.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.67	0.71	-4.05	171	5359	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	4803	48	1566	4094	1764	143.70	39	46.08	CHANGED	++...hh.....p...h+....KlGHsGTLDPhAoGlLslslGc.ATKlhpalh.sss.KpYpuphpLGhpTsTtDtpGpl..l...tp........h.tl.sppp....lcpsl.ppF.pG.pIpQlPPha.SAlKhsGc+LYchARpG..hpl-...hts.RplpIaplcl...lph..p...ts.......plphclpCS+GTYI	............................++lhpsc...KsGHsGTLDPhAoGlLslsl.Gc.ATK.hs.p.alh..sss..KpYpsplpLGtpTsTtD...........s..........pGpl.........l....pp...................s...p.h....s...t..cp.....................lp.p........sl.p..p.a.pG...pI.pQ.....lPP.haSAlK.hpG++hY-hARpG..........p..V..c.........p..ts..R.lsIaplph.....lp...h.....c..ts..........................phphcVpCSKGTYI....................................................	0	520	968	1305
+4756	PF01456	Mucin	Tryp_mucin; 	Mucin-like glycoprotein	Bateman A	anon	Prodom_3102 (release 99.1) & Pfam-B_3837 (Release 8.0)	Family	This family of trypanosomal proteins resemble vertebrate mucins. The protein consists of three regions. The N and C terminii are conserved between all members of the family, whereas the central region is not well conserved and contains a large number of threonine residues which can be glycosylated [1]. Indirect evidence suggested that these genes might encode the core protein of parasite mucins, glycoproteins that were proposed to be involved in the interaction with, and invasion of, mammalian host cells. This family contains an N-terminal signal peptide.	29.60	29.60	29.70	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.34	0.71	-4.41	6	1107	2009-09-12 22:44:45	2003-04-07 12:59:11	12	5	11	0	62	1096	1	150.00	37	94.82	CHANGED	Mh.....hpRlLC.lLhLAL.CCssVCsTApt..............................................tGQhssssspuusGpsppTTTTTTTpssTTTTTTT.................Tssss....sspsssTTsssTTTTTsspAPupssTTocAPTssssR..........SLGussWVssPLLLhVSAhshT..Ass	......................................................................................................................Mh...pCRLLCALLVLAL...C.C.C..s..sVC.s....s..tpt....................................................................................................................................................................................................................t..........t....t............t.....s......t.....t.....s....ps........p.....t.....p........s...s..s..s..s....s.....p..s.s...s.s...s.ps..sp................................................................................t.t.t........s.......t....t..p....s...s.....p...s.s...s..s.s.s......s......o........T....T....T.T.T..s..sp......A.P....s...........s.....T.T.o.cAP....o.s..o.......TT.+A.P........Stl.RchDGSLuSSAW.....VCAPLlLAsSALAhT..sl..........................................................................................	0	3	3	62
+4757	PF00913	Trypan_glycop		Trypanosome variant surface glycoprotein (A-type)	Bateman A	anon	Pfam-B_1351 (release 3.0) & Pfam-B_2618 (release 8.0)	Domain	The trypanosome parasite expresses these proteins to evade the immune response. This family includes a variety of surface proteins such as Trypanosoma brucei VSGs such as expression site associated gene (ESAG) 6 and 7 [3].	22.10	22.10	22.10	22.20	21.90	22.00	hmmbuild  --amino -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.08	0.70	-5.55	63	493	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	12	4	163	485	0	305.80	17	79.35	CHANGED	hshhllhshh......sppssussptulpts.sWpslCplop-Lc.plsutshpphpshhsthpphpptth+hplash....tpsssppspthsslsuhh....ppstpshpshhssthppulsAsusuuhltG+IcEalsl...hspspsuuss....CLssssssssssss.........hthstspsphphsssssp...stssstlsssGapshh...........sssssptssssppCpLh.....tsssssGhspsss.........tssslphu.uGhlsls.....tsssthshtthtshttttptttt.hhthhtt..........tptspssssthpssssshpsssphppslpphht.....tptttptpphtptlpphhtsspspthpt....hhttht.p.plstthh....stsptspLs.cIssh.ppLtplLthhptptt	.................................................................................h....hhhhh...........h...ts...t...t.t..u.lttp.shptlCsloptL+.t..............lsthst....p....pht.......t....h...t.p.ph....p..ph.p.....t....h..p..h..p....lhhh.........htsst..pss........ptht..h......Lhtth......hpthtphppphpph........t....ptuhtAuu....tA........uhuAGRl-Ealtl...........Fup..ut...........s....susph............Clusssssssptsp....................thp.s.tth.hppspps........htttpshss..tshpsl............................sspshts.s.ss....pss...CsLh.......pssssG..hhtsss..................hppshhau..uGlhshs...............t.t..........................................................................................................................................................................................................tt.........................................................................................................................................	0	121	163	163
+4758	PF03249	TSA		Type specific antigen	Bateman A	anon	Pfam-B_3060 (release 6.5)	Family	There are several antigenic variants in Rickettsia tsutsugamushi, and a type-specific antigen (TSA) of 56-kilodaltons located on the rickettsial surface is responsible for the variation [1,2]. TSA proteins are probably integral membrane proteins.	19.80	19.80	20.30	30.10	19.50	19.30	hmmbuild  --amino -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.73	0.70	-5.96	8	365	2012-10-03 17:14:37	2003-04-07 12:59:11	8	1	7	0	1	363	0	374.30	72	96.08	CHANGED	IELGDEGGLECGPYAKVGVVGGMITGVESsRLDsADu-GKKHLPLTTuhPFGGTLAAGMTIAPGFRAELGVMYLpNIoAEVEsGK..............ssucADosssTD...uPIhKR..KLTPPQPTIMPISIADRDhGVDlsNlPQAQstts..QlNDs..RuAcRIAWLKsYAGIDYhVKDPNNP.GsMhlNPVLLNIPQGNP...uNssptAhQPsDhsILDH-QWRalVVGlsALSNANKPSlSPVKVLSDKIoQIYsDIKPFAcIAGI-VP-ssLPNSASVEQIQNKMQELN-lLEELRESFDGYI.GNAFAsQIQLNFhIPQtA..QQQQGQG.QQQQAQATAQEAsAAAAVRlLNG..N-QIlQLYKDLVKLQRHAGIKKAMEKLAAQ.t.DutspGuGDsKKKQG...ASEcSccsutu........KETEFDLSMIVGQVKLYADLhTTESFSIYAGVGAGLAYTpGKIDsKDIKAHTGMVASGALGVAINAAEGVYVDIEGGYMHSFSKIEEKYSVNALMASlGVRYNF	........IELG-EG..GLECGPYuKVGlVGGMITGsESsRLDsADs-GKK+LsLTTuhPFGGTLAAGMTIA.GFRAELGVMYLpNIoA....pVE...GKsKs.....................DStGcsKADSu.sGsD.....API.RK.R.hKLTPPQPTIMPISIADRDhGlDlsNlsQAtAtts....Q..LNsE...QRAAtRIAWLKNhAGIDYhVpDPNNP..GshVlNPlLLNIPQGsP...uNs....pRspQPsshsIhs..H-QWRaLVVGlsALS.NANKPSsoPVKVLSDKIopIYSDI+.FAcIAsI-VP-ssLPNSASVEQIQsKhpELsphLE-lR-SF-Ghl.sNAFssQIQLNF.hP.tt....QtQ.GQ..QQQQ..uQsTAQ-AsAAAAVRhLNs..NpQI.QLY+DLVKLpRHAGl+KAMEpLAsQ..........D.stt.............ps..tspscppp....ss.p.pp.....t.t..........+.EsEFD...LSMl..VGQVKL..YADlhhTEShSIYuGlGAGlAaT.GKIDshDlK.pTGMVsS...............................................................................	1	0	1	1
+4759	PF01166	TSC22		TSC-22/dip/bun family	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.10	25.90	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.89	0.72	-4.01	10	339	2009-09-11 08:14:02	2003-04-07 12:59:11	13	4	87	2	161	275	0	59.20	65	15.71	CHANGED	MDLVKoHLMYAVREEVEVLKEpI+ELh-+NupLEpENsLLKsLuoPEQLsphpu..plpsss	.................MDLVKSHLMYAVREEVEVLKEQI+ELhE+NSpLEpENsLLKoLASPEQLuQhpu..pht..ss..................	0	26	42	96
+4760	PF04668	Tsg		Twisted gastrulation (Tsg) protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4556 (release 7.5)	Family	Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling [1,2].  	25.00	25.00	29.60	27.40	18.40	24.10	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.06	0.71	-3.95	11	135	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	83	0	82	122	0	122.90	45	58.17	CHANGED	psphop+SplE-L.-ulPsLFcAlTu..EsDut.hpWslhoFPl....h..hsptpshsphL.s.ss.pts..htsPsssloss........CTVlYhspChShp+C+QoCESMGASpYRWFHsGCCECVGspClsYGspEoRCppC..	........................................s.s.opKSpVE-l..-s..lP...uLFcALT...Es..Dst...hpWslhoFPl....s.thsphc.s..hspah.ph.s...p...p.....hp......h.s.......h........sss.hpss.............CTVlYhcpChShppC+.oCcSMGASpYR.............WFHsuCCEClGspClsYGspps+ChpC..............	0	19	25	55
+4761	PF04705	TSNR_N		Thiostrepton-resistance methylase, N terminus	Kerrison ND	anon	DOMO:DM04814;	Family	This region is found in some members of the SpoU-type rRNA methylase family (Pfam:PF00588).	27.10	27.10	27.70	93.80	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.38	0.71	-4.29	3	6	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	6	6	1	11	0	114.70	52	41.82	CHANGED	MTELDlIsNsSDPAVQRIIDVTKHSRSsIKTTLIEDlEPLMcSIRAGVEFIEVYGSDooPFPu-LLDLCc+RsIPVRLIDuSIVNQLFKuERKAKVFGIARVPRPARFADIASRu	.MsphDlIsstSDPAVQRIIDVTK+SRSslKTsLIEDsEPLscuIpAGVEFIEVYGs-uoPlsscLLshCcpRsIPVRLlssulsNpLFKuERKsKsFGIARVPRPu+FuDlAsR.s.	0	0	1	1
+4762	PF00090	TSP_1	tsp_1; 	Thrombospondin type 1 domain	Sonnhammer ELL	anon	Published_alignment	Family	\N	21.60	12.00	21.60	12.00	21.50	11.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.19	0.72	-3.85	31	18854	2009-09-12 10:45:09	2003-04-07 12:59:11	14	787	233	25	10470	16743	573	50.30	28	19.16	CHANGED	o.WspWSsCSV.TCG.pGhphRpRhsst......sssCstsspp......schC.phcpC	..............h.u.sW....o.........t....C.......S......t.....o.......C.........G.....s.......G........h.......p.....p.....R.p....+...p..C.....t..s....................s......s...p..............C....t......s......t..t..t....................hp.....C..p.t.C........................................................	1	2752	3498	6471
+4763	PF02412	TSP_3	tsp_3;	Thrombospondin type 3 repeat	Bateman A	anon	SwissProt & Pfam-B_2972 (Release 8.0)	Repeat	The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats [1]. The repeat lacks defined secondary structure [2].	25.00	13.60	25.00	13.60	24.80	13.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.18	0.72	-4.48	11	4235	2009-09-16 13:31:17	2003-04-07 12:59:11	13	198	363	36	1963	3922	3104	30.90	43	18.51	CHANGED	cDuDuDGlGDAC....-pDhDsDGl.shhDNCPhsuNssQ	.....................................C................p..t...D...t...D..s..D.G.l..D...p......p.......DsCPhsss.t..........	0	606	831	1367
+4764	PF03073	TspO_MBR		TspO/MBR family	Mifsud W	anon	Pfam-B_1882 (release 6.4)	Family	Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light [1]. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates [3]. In [2], the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.	20.70	20.70	21.20	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.98	0.71	-4.68	148	1274	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	1043	0	537	1142	1226	141.80	27	85.38	CHANGED	llhlslshssuhhuuhhoss........ss..W.YpsLpKPsasPPs.alFsslWTlLYhhhuluuahlapth.........tpptsphslslaslQLsLNhhWSslFFuh+......phthAhl.llhLhlsllhshhtahp..lsphA.uhLllPYlhWlsFAshLNhs.lhtL	...............................................h.hhhhhshhhuhhuu....h....h....s......t.......tp....W...Yt..s.Lp+P...s.asP...Ps..hlFs.lWsl..L.Y.h.hh.u.l.uuahlapp.........................ttpttphsltl.a.sl.QL.hlNhh..Wo..lF....Fsh+......phhhAh.ltlllLhhh.lhhh.....h.......hha.hp.......lsp...h..A...uh..L....h....l.....P...............YlhWlsFAshLNhslhh..................................................	0	183	330	441
+4765	PF02956	TT_ORF1		TT viral orf 1	Bateman A	anon	Pfam-B_1612 (release 6.4)	Family	TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.	19.60	19.60	20.10	19.60	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	525	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.85	0.70	-6.05	58	3965	2012-10-04 01:49:40	2003-04-07 12:59:11	9	3	72	0	0	2670	1	111.10	45	87.44	CHANGED	Msa.WWhRR....R+...WhhphhR...................RhRRhhRRh+RRhps..RR..RRR.hhthp+....RphhRRRp....hRR++KKl.hlpQWQPsslR+CpIcGhhPlllsGc...sptspNYshcp--hss.....t..........PaGGGaosppFoLchLY--ap+tpNhWTtSNppLDLsRYhGsphpFYRHspsDFIVpasppPPFphschotsshHPuhlhhsK+KhllPShpT+PpG+thl+l+IpPP+hhpsKWYhQpDlCsssLlsltuoAsshpaPasusposs.sloFts.Lss.hYppshhh............................sstppt.t.h.t.laps........................thYpohts.tpl.p.httssptpp....ttp....t................................sss.Yst..ap.........................................................tlpYcsGhaSshaLssh+h.shp.h..............ssat-lpYN.PhpD+GpGNplWh.p.hoKtsspa...spspschllpslPLWsshaG..Yh-alpppt.tspshhtsthlslhsPYTpP...hstss..sshual.hDhsFspGKhPts.sshlshhhct+W.YPphhaQppsls........slspsGPa..sY.+s-ppss.pLs..hpYcFpFpWGGs	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..Kps..Y...sKspSKCLltsLPLWAusYG..YhEaCuKsT..GDs..N..IchNsRhl.IRSPaTsPQL.ls..H..ss..P.+GaVPYS..........................................................................................................h.........................................................................................................................................................	2	0	0	0
+4766	PF02957	TT_ORF2		TT viral ORF2	Bateman A, Mifsud W	anon	Pfam-B_1489 (release 6.4) & Pfam-B_4693 (release 7.6)	Domain	TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.	21.10	21.10	21.10	21.10	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.77	0.71	-3.41	17	774	2009-09-11 23:42:44	2003-04-07 12:59:11	10	4	129	0	1	695	0	100.80	26	68.28	CHANGED	apPs...hastpthptpWhsshhpoHshhCGCscslcH.......hhp..........................hh+ptssL.ht.pt.tpht.h..sssp-uss.......tssG-s.t..sh......spuDlDhL.hAt-hs-p	....................pss...hhs.ptppphWhpsshpoHushCuCssshtH................Lpph...t...th.t....................s.s.t.s....t.t......h+h..........h.........................................................s.s.t..t...tt.................................t..............................................................t.t...p...........s....................................................................	0	0	1	1
+4767	PF03542	Tuberin		Tuberin	Griffiths-Jones SR	anon	PRINTS	Family	Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. The TSC2 gene codes for tuberin and interacts with hamartin Pfam:PF04388 , containing two coiled-coil regions, which have been shown to mediate binding to tuberin. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking [1].	19.50	19.50	19.60	21.20	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.15	0.70	-5.39	5	261	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	189	0	169	279	0	274.60	30	18.27	CHANGED	lV+SEsElEDIlsAVDGLl+VFpVKLYRLPusHAl+VYslLluHLEtHYc+PalLtplSlIRY+IF-WhLpARANuSaHIGYP-uE..pss+VRFSsYLGl-uP...............ppupuosphsLs.hussptsspssslhPsosLTsISI+RuCpVIVpCLKcEpDWpVlQLVLoELPcVLQNKALIQGND..lDuLAsTLhKMhsD.hplE+L.pusstusspoDlHsLVLPALoSLAoYHpaLDsspQ+sIIsuLcpGLIoRpASlCIsoLTILlLEMP-sLhs+LPDLLlcLSKMSuTshlAlPVLEFLSTLlHLPpHLauNFssppYMsVFAISLPYTNPaRYDHYTVSLAHHVIAuWFlKCRLPh	.............................................................................................................................................................................................s..........................................................................................................................................................................................................................................................t....h....p...s.......hl..shshhhpsllphL.c.p-sDWcVhphVLs+Lstp......Lp.+sLhh...s...ss...plcpLpssLsph.l....p..................s...h..h..................c...ph.....tt..ss..p..s.hp+sDlthsl.h.sLosLloYHphh.s..+sc..........pc....-hVtsh..pG...l..h..p..........c..........s...A..pt..C..l...hALolCshEh.P..sl....hKtLssll.s+h.o+l.s..oss.hAl...lLEFLusLuRLP.pLYtNFtt-patpVFuIsl.Y...............h....p.................st+....................t.................................................................	0	54	81	133
+4768	PF00091	Tubulin	tubulin; 	Tubulin/FtsZ family, GTPase domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.38	0.70	-4.52	94	20546	2012-10-03 12:11:42	2003-04-07 12:59:11	20	44	10719	170	3790	14692	2809	152.80	36	51.77	CHANGED	pIhslslGsuGsphssphhc.................................................................................psh.s.schlhlsTDspslsp.hpsspp.....lhhspphhpGh..G..AGus.t.hGpp.................................stccshcpI.cctl............c.s.hchhhlssuhGGGTGoGhusllschh+-h.................................s........t.lsluhsshPh.....ph.Eshhc.hsAhhulppL.hcpsDsllllsNspLhc........ls..............spphslp...................ssapp	...............................................................................................................................................phh.t.thhp.....................................................................................................................................................................sshhs...sc.h.l.hlsh.-.s..t..s...h...........ct....s.......+........s...ush.................l...hs.........cp..h....s....h.....G..........G................AGsN.......t....hGc.................................................................................................hhc.s.h-...l...pp..h...................................p...s.h.....p................h..h..lh.tuhG.G.G..TGs.....Ghu.sllh....ph.hp.p..................................................t......h..hhhsh.s.s..h..P.............ph..-s.h...h..c.......h...........t..u.....uh..ppL......hc......p...........sD.....p.....h...hhlsN..pt.lhc..................ls......cp.hth...sa..t....................................................................................	0	1325	2173	3053
+4769	PF00418	Tubulin-binding	tubulin-binding; 	Tau and MAP protein, tubulin-binding repeat	Finn RD	anon	Prosite	Family	This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilise microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau (Swiss:P10636) is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif [1].	21.60	21.60	22.50	21.70	20.70	21.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.32	0.72	-4.26	12	1318	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	98	0	474	1352	0	30.90	51	14.99	CHANGED	Vplhsptl.Dlp.pVpSKsGSp-NIKHpPGGGp	..........VpI.spKl.Dhp..pVpSKsGSh-NI+HpP..G..GGp...	0	102	146	270
+4770	PF01021	TYA		TYA transposon protein	Bateman A	anon	Pfam-B_90 (release 3.0)	Family	Ty are yeast transposons.\	\	  A 5.7kb transcript codes for p3 a fusion protein of TYA and TYB.  The TYA protein is analogous to the gag protein of retroviruses. TYA a is cleaved to form 46kd protein which can form mature virion like particles [1].	25.00	25.00	26.50	26.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.43	0.72	-3.79	4	183	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	13	0	119	181	0	91.70	76	12.65	CHANGED	ACASVTSKEVpTNQDPLDVSASKhpEa-+sSTKANSQQpTTPsSSAVPENtHHASPQsAQsP.PQNGPYpQQsMMTsNQANsSGWuhYG+PSMMPYoP	AhASVTSKEVpoNQDPLsVSASpl.EaD+sSTKsNSQQpTTPuoSAVPEN.HHsSPQPASVPPPQNG.Y.QpsMMT.NQA.sSsWuaYt+PSMhsYo.........................	0	88	88	88
+4771	PF03251	Tymo_45kd_70kd		Tymovirus 45/70Kd protein	Bateman A	anon	Pfam-B_3418 (release 6.5)	Family	Tymoviruses are single stranded RNA viruses.  This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase [1].	25.00	25.00	192.80	192.50	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	463	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.37	0.70	-5.80	13	23	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	0	0	23	0	464.50	32	74.92	CHANGED	MSNGhPsSsRpshlcpoQtplhpssochtssssstLssslPLcpscGosohsphlRcPsl+hRhpssPPssPQssRs.soLpPL-hstpsuhhscVHETlcVppsstppspL.pssQLPupspRhpSlPpHLphsupttsRlHARRuDVL.uhosstslpslspsssslLQspsusRt.LHRsLshPpsLHLps.RppsuL+sR+ospRpLQsAsppspLAEsthH..s.spPlpppsGILGPsPLhscspR..........sPpsshppssss..........................slLPsPphspuupuaLPsPTossPs+sspulpRslHLHsSpssosclRPpRlRssulQQspspLGHspuLGQSsNLRusppspPo+pplpLhPhssspspsl.hssh........sP.hppp.Sh....hP+Psss.sshstsssp...hpsplPssh.s.......ssphsssss......suhssssssssssssss...............Ps	MSNGhPsSsRRshlapSQRplsposSchpspssstLsssLPLspscGosuhsphlRHPslRhtppPsPPppPQssRs.soLpPLthPtppShhpcVHEThpVppsstppscL.pspQLPspspRp+SlPpHlppsu..pptp+lHARRsDVL.uhssptslpshspsssslLQspsuoRt.LHRslsLPcsLHLps.tsposL+sRco.pRpLQsAsppPhLAcsphH.....s.s.slpcpsGILGPsPLsscspR.s..............sPpsthspssss.............................h.s.t.slLPss+h.poSpuHLPssTsssPspsspuLpRPlHLHpSssposchRPpRlRpculpQscspLGH.psLGQSusLRsscpssPs+ptLpL.spPstpspslspssL........sP.httttSh.h..hPpPsshhsshshsosp...hphplPpsh.s.......spth.ssss......sphshtsshpss..sss.h.....ssss..s................................	0	0	0	0
+4772	PF00983	Tymo_coat		Tymovirus coat protein	Finn RD, Bateman A	anon	Pfam-B_1429 (release 2.1)	Domain	\N	19.00	19.00	20.10	26.20	17.90	17.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.92	0.71	-4.56	9	153	2012-10-04 01:49:40	2003-04-07 12:59:11	13	4	51	27	0	158	0	167.60	34	41.30	CHANGED	ps.QssIsssuopLP.ssGppsPoIl.PFQhpssohGsp-susplolAotssluplTohYRHApLspLpAsIpPouhAsupPsTVsLsWVPsNSoATsupILs..lYGGQpFslGGuIsospsIpVPssLssVNPhIKDSVpYTDoPKLLlYSsAsssss..sssTsolpIpGplp	....................h..............s...s.sssslslPFQh.p.shsh.Gst.s.s.t.s.ols.luussslopLsusYRHApLhpLcAhltPshsuhupPholslVWssAs.ssssssplLp..sYGGpphslGGslshsushpVPAsLsplNPhIKsSVsYsDTP+L.hh.sssssssus.....sssh..shlhlpGhl.............................	1	0	0	0
+4773	PF00264	Tyrosinase	tyrosinase; 	Common central domain of tyrosinase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family also contains polyphenol oxidases and some  hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.	22.30	22.30	22.30	22.30	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.22	0.70	-4.19	127	3739	2012-10-01 19:27:11	2003-04-07 12:59:11	15	75	1610	58	1016	3969	31	141.50	35	41.98	CHANGED	tspapphs.................uhHt................................................thshs.hHs..ss....hFhsWHRhYlhhaE.....ptLpp.................ts..................sssthtlPYWDWs..........................sps..ht.ssslhs....ss.h.uh....................................t.h...hss...Fs..shhsph.......................................p.cshp+sh..........................ssttspthsstpp........................ltphlht..................................sshpsFpshh...ps.................................thHsssHh.hlG......................................Gp...............h....ushhsushDPlFalHHuplDRlathWQph	..........................................................................................................................................................................................h.psYDhFV................hlHhhsscss.......................................htss.sh.pshch.uHp...us.......uFlPWH.RhaL..L.haE.....+plp+....................ls.........................sspsFslP..a..Ws.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	335	609	862
+4774	PF03064	U79_P34		HSV U79 / HCMV P34	Griffiths-Jones SR	anon	Pfam-B_2985 (release 6.4)	Family	This family represents herpes virus protein U79 and  cytomegalovirus early phosphoprotein P34 (UL112).	23.20	23.20	23.20	24.60	22.50	23.10	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.82	0.70	-4.86	5	51	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	24	0	1	53	2	236.80	47	48.69	CHANGED	RcYGTF-NVscsYcQIVocolcLRRacF-oGClI-FlusSG+CEsausGWIS.MIhWTSETsS......tGSLTlDIssD-GppKTY..pARGtILCSKSITSISQso...EG+-+lLTlspENGKLQlTaVTlsKsu+-s-l+slG.DsKstcpFEKECpAs-RKKp...DD-++K+SuKQKEKRRsED..cK+cEDc+KKpE.......c++psDs-Kpsspc-cu.sttpp..pph.........D.....psscEKRQK.aH-s..-RcLEcQScE	.............R+YaTFsNssRlLHQsVspoFDVRQFsFDoARlVsCl-G-G+s.phsKGWLC.ATIMQpu-uuuuu......pstQGhMSlDITuDspLpcph..FsRGuIVhNKoVSSVVGss....ssscuuLLThluEsGsLQVTaVcHhh.psHs...psusssu.....usGsAusAu..AVs.s.....oShGuS.......uGspcGsus.ppppRRRpc..........ppH--cR+Kppp.....................pttsu..GuuGuuGGG.s.GuGSGGppu..sotp....thLc-...........st..pRQK.......ERc..Pspp.........................................................	0	0	0	1
+4775	PF02134	UBACT	UBACT_repeat;	Repeat in ubiquitin-activating (UBA) protein	Mian N, Bateman A	anon	IPR000127	Family	\N	20.50	20.50	20.70	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.08	0.72	-4.40	128	1697	2009-01-15 18:05:59	2003-04-07 12:59:11	16	51	346	44	1116	1656	35	65.80	34	11.72	CHANGED	pF-cDDsss..lcalhusuNlRAppasI..s...h...............shhps+tls.upIIPAlAoTsAlluuhs..shEhhKllpsp	..............F-pDDssp....lcFlhuuuNLRApsasIp.s...t...............sp.tps+.t......ls..spI.I.PAlAoT.sAhlsuls..shEhhKlht..t................	1	397	620	910
+4776	PF01977	UbiD	DUF117; UPF0096; 	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has been characterised as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes [1]. This enzyme catalyses the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+ [1].	19.80	19.80	20.40	19.80	19.40	19.70	hmmbuild  -o /dev/null HMM SEED	407	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.04	0.70	-6.02	155	3152	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	2165	3	810	2356	887	380.40	36	83.80	CHANGED	lptL.ccpG..p....Lhclcp.Vs.spL....Elutlsc+........hhp........t..tss....AlLFcsl...cGh.........hsll.sNla...u.op........cRlshsL.Gh.........phpplsppltphh.p.................ht.hsh.hphh............pusspcshh..tpphD..L..pc.LPlhppaspDGG......alTh...................uhVloc..sP.cs.......NlGhYRhQ.lhs.....c.pcluh+hh..t+css.phap...ch....pcpG...........................c..phPVAlslGs-PshhhuAs.hP...lP...slsEhthAGhLp....Gpslcllcst...sssL.VPAsAElVlEGhls...s........p.ht....EGPFGDasGY.Ys..scp....hPVhcVpslptRc..c.PIa.ss.lsGpPs..tEcphlutsspchhl...shlptthP.p....lh-lhhs.tusha..hsllsIccpa........sGc.........u+plhhuhaustt.h....hsKhlllV....D.cDl-lpDhppVhWAlso.....Rhcss+.....Dlhllsss.s..ss	.............................................................................................................................................................................phL.-ppG..pLh+I.st.Vs.sphElst..l.scc.........sh+...................s..tGP....ALLF-Ns...p.Ghs........hPV.l.sNla...G.o........................cRlAhuh..G.................shpplsc...h..l.shhhc....................................h....sh..phl............................psusspp..lh..p....u..-c..l.s......L.............tc..lPl.ps.ast.Duu....................shlTh....ulslo.+..sPpc.........tppNlG..IYR.Q..lhu.....+.s+lhh....+als....p+ssA.hc.hp..ch....t.c.....G............................................c..t.hPlulslGsDPshhluAssP........l.P.........sl...oEh.thAGhLR....Gp.hclsps......s...s.s...lpVPAsuEllLEGhlp.................s....................tcht...E.......G.......P......a...G.....DaTGY....Ys..tscp......hPVhplpploh.Rc...c..sI.apoT.hs.G+..P...s...sE.sshLussh.s......clhl...sl.Lp..p..phP..E....lhD.hahP..p.G.ssa...hAlloh.+K.pY..........sGa.........A+pVhhusaohhpth....asKhlIls..................D....-D...l.s.scDhscVlWAlso.....RhcPsRDhlhlpsssh................................................	0	231	482	658
+4777	PF01209	Ubie_methyltran		ubiE/COQ5 methyltransferase family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.45	0.70	-5.25	5	4079	2012-10-10 17:06:42	2003-04-07 12:59:11	13	9	3618	4	1229	27075	9319	227.00	38	91.29	CHANGED	pTslKEp+...VpcVFcSVAo+YDhMNDVlSFGIHRLWKc.FTh+psus+cGs.....shLDVAGGTGDlTFcLo-ulGsoG.............KVlllDINEsMLKhGccKl+-pGhh....sIEaLpuNAEcLPF-D.soFDslTISFGLRNsoDh.KuL+EhaRVLKPGGpllCLEFS+PphPlhcpAY-hYuKtVMPhhG+llAc-h-SYpYLsESIRcFPDQ-TLcuMhc-AGFcuVcYcsLTGGlsAlHhGhK	............................................................................................................................tp....Ktpc...VtplF.c.s..l..A.s.+....Y..D....l.....h.....N......c......l....h....S.........h.....G.....h......H.....+....h.......W...+........+......h...s....h.....p.........t....h.........s......s.....c.........G.p...................................p.l..L.....Dl..A...u....G....T....G........D...l....s....h....t....h....u....c...t....s...s..t....p..u......................................................c.V.s..h..s....D.....h......s........p.......s.......M.......L......p......l.....G......+......c.........+.........h....h.........p.....h....s..h...........................s..l..p......a......l.........p...............u........s...............A......p........p........L.............P.................F.................s..........D.......s.........o...........F..........D............s......l........T...........I.......u............F......G............L...........R.............N............V...........s.......-...........h............p.............p...........A......L........c....E........h....h.....R.....V.......L..K....P...G.....G.+..l........l...........l........L.........E.....F.........S.......p.....P......p.......h...............s........h....p....p.....h........Y..........c......h......Y..........h......p.............l.....l...P......h.....h...G...p......l.......l...u...p.....s...t.......c..u......Y...p.....Y.......L...s..E.....S.....I...c.....t.......a.P.....s...p....c..p......L.....t......th...h.p...c.AG.F............p.....p..l......p........a......p......s.ho.uGlsAlHhGhK.........................................................................................................................................	0	414	798	1059
+4778	PF03981	Ubiq_cyt_C_chap		Ubiquinol-cytochrome C chaperone 	Finn RD	anon	Pfam-B_5272 (release 7.2)	Family	\N	21.50	21.50	21.50	22.20	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.60	0.71	-4.33	63	1111	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	985	0	313	697	717	153.30	26	61.36	CHANGED	pphsls-ThsucaphhsLHhallhhR.................l+sts...ttu.....ptlsQplh-thhpDh-ppl+chuls-hsl...sKph+ph....sptahGthhAYDpulst...sstsLusALh.RNlhpst................shp...phttlssYltpthttLsshsspslhsuth....ta	..................................................................chp..phlsuchphhshcshhshlR..................................LKu-t........hus.....hplpQpLl-pahccs.pchc.c..t..p..h.p-hht........stplpcL....pphh.hhht.sh..hAhss...........hsspL..sthLtpphhhuh........................................................................scshh.....chsuLsu.Vtsslss.lcsluusuhtssh...ssh.....................................................	0	109	180	253
+4779	PF02271	UCR_14kD		Ubiquinol-cytochrome C reductase complex 14kD subunit	Mian N, Bateman A	anon	Pfam-B_4192 (release 5.2)	Family	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [1]. This Pfam family represents the 14kD (or VI) subunit of the complex which is not directly involved in electron transfer, but has a role in assembly of the complex [2].	20.70	20.70	21.20	29.60	20.60	19.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.12	0.72	-4.27	25	388	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	303	52	242	377	2	101.50	37	76.61	CHANGED	lhppPtLs+lhhPlAphahN..huGYRphGL+hDDLlsE...EssslpcAL+RLPccEsYsRsaRItRAtQLSloHplLP+ccWTKsEEDssYLpPYlt-lcpEtpE+p-	..........................h..........hh.s.ltpha.hs......suG..ap..ch.GL+...........hDDll.E..........s.sVpcAl+RLP...cc....h.sRsaRlpRAhp....LShp+plLP+-p.WsK.-...-D..h......Y...LpP...hlp-lppEppE+p......................	0	77	127	196
+4780	PF02320	UCR_hinge		Ubiquinol-cytochrome C reductase hinge protein	Mian N, Bateman A	anon	Pfam-B_11849 (release 5.2)	Family	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [1]. This Pfam family represents the 'hinge' protein of the complex which is thought to mediate formation of the cytochrome c1 and cytochrome c complex.	22.00	22.00	22.20	24.20	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.41	0.72	-4.03	24	379	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	288	52	237	373	5	64.70	37	55.86	CHANGED	VDPhppLcEcCttpscCsphhpcappCscRVpucsp........scEsCspEhFDhhHClD+CVA..KLFspLK	................DPhpplcEcCtpptcC..sphhc+a-pCs-RVpscsp...............scEcCsEEhF-hhHshDcCsA..KLFppLK..................	0	78	131	193
+4781	PF02921	UCR_TM		Ubiquinol cytochrome reductase transmembrane region	Griffiths-Jones SR	anon	ref [1]	Family	Each subunit of the cytochrome bc1 complex provides a single helix (this family) to make up the transmembrane region of the complex.	19.90	19.90	20.20	20.00	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.09	0.72	-3.74	30	409	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	305	58	228	405	5	61.80	36	24.87	CHANGED	upTch..phPDFo......sYcccp.........css-sp+uFoYhhl.GuhulhsAsuAKssVpsFlSoMSAS....AD	....................psh..phPDFs......pYccpp..............pusss+....+uFoYhhs.Gu.....sulssAhuAKssVppFlsoMSASAD.....	1	79	127	188
+4782	PF02939	UcrQ		UcrQ family	Bateman A	anon	PSI-blast P13271	Family	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [1]. This family represents the  9.5 kDa subunit of the complex. 	25.20	25.20	26.70	26.40	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.49	0.72	-4.16	7	257	2012-10-01 20:10:32	2003-04-07 12:59:11	11	4	223	52	177	256	0	78.40	35	78.44	CHANGED	hhtahshsK.+GIhoYulSPapQ+shsGhFcpul.NsFR.RspophLYhs.PhshhYhlashupcpNphL.pKsstc.hpc	..........................hht.hhsh.s..+..+tlhoYuLSPacQ+shsGhhppul.Ns.aR.Rh+.sphhhVsP...PhlhsYhlhsWupccpchhppKsstt..t...................	0	51	86	144
+4783	PF00984	UDPG_MGDP_dh		UDP-glucose/GDP-mannose dehydrogenase family, central domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1105 (release 3.0)	Domain	The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate [2].	20.60	20.60	20.90	21.50	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.83	0.72	-3.77	26	6968	2012-10-02 19:36:47	2003-04-07 12:59:11	14	24	3680	103	1988	5681	4792	94.60	34	22.22	CHANGED	lpoAEhlKhssNsahAs+IoFhNElupIs-plGsDlpcVhculuhDsRls....ahpsG.GaGGuChs+DshsLsttupphshssp..hhppllpsNpsp	...............psAEhsKlhsNsahAh+IuahNElu.p.ls-p.............h..G..l...slpclhcussh....D.sR..ls...............hh.pP.G.....G.a.GGpClPKDshtLl.t.p.s.p.p...sh..p.....llpthhpsN...t...............................	0	678	1317	1697
+4784	PF03720	UDPG_MGDP_dh_C		UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1105 (release 3.0)	Domain	The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate [2].	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.49	0.72	-3.89	161	6858	2009-01-15 18:05:59	2003-04-07 12:59:11	10	20	3675	103	1921	5532	3768	98.00	25	23.17	CHANGED	ulLGluFK..ssocDhR-SPulsllptLhpp...Gu.....p.lpsaDP..hstptthth.........................................tlph..htsh..tcslpssDslllhT.-a.spFcp.h...s.tthhphh....pss.llhDsR..slh.ct	....................hlhGLsFK..ss..oDD..h.R-.Ssuhslhcp..Ltp.t..Gs....................c..Vh.laDP..hspppthth................................................................................................slph.h.p.sh...tpsh.p..s.ADslll.ss.cappacs..h......................t.t..h..................tt.....hlhDs+shh................................................	0	659	1277	1636
+4785	PF03721	UDPG_MGDP_dh_N		UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1105 (release 3.0)	Domain	The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.95	0.71	-4.91	27	7072	2012-10-10 17:06:42	2003-04-07 12:59:11	9	27	3696	103	2033	10113	8347	178.30	31	42.76	CHANGED	h+IullGhGYVGLssusshuphG..hcVlslDIspp+lcplspGp.PIhEPGLpcllcpsh...pLphoschppslcpuDlhhIsVsTP.cp.....sptsDLpalpssscpluphlcp...tpllVh+STVPsGoscthhh.llpchstht.........hcatls.sPEFLpEGsAlpDhhpscRlllGspspsst......thhpcl	.................................................+Isl.l.G.h.GYVG.L.ssu..s..h..hApt.s........hc...Vl..u....l...........D............l.......s....t...........p.......+....l.....c....t.........l.............s........p........G......p............s......I......h...........E.....s.........s.....l......p.....c..........l.........l.....p.....p.....s.......h..............................................h..................p......l....p...h....o....s......c.....h..p.....p......s...h......p......p.....u..D.hhh.....I..A..V...s.T..Phct..................stp.s.D......h.....s..h.....V.....p.u.....s.s.c.s..lu.p...h.hpp.................hsll.l.h.c.S.T..VP.V.Gss...c..h...h.t......lh.c.p.h.ss..............................php.....ls..a..sPEhlp..pGp..u.l...hD...hh.p.s.sRllsGhssppst.........hh..........................................................................................................................	0	686	1345	1734
+4786	PF01704	UDPGP		UTP--glucose-1-phosphate uridylyltransferase	Bashton M, Bateman A	anon	Pfam-B_1634 (release 4.1)	Family	This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and  Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyses the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi [1]. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type [1]. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle [2]. Also within the family is UDP-N-acetylglucosamine Swiss:Q16222 or AGX1 [3] and two hypothetical proteins from Borrelia burgdorferi the lyme disease  spirochaete Swiss:O51893 and Swiss:O51036.	19.70	19.70	19.70	19.80	19.20	19.60	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.43	0.70	-5.98	8	1651	2012-10-03 05:28:31	2003-04-07 12:59:11	13	13	879	45	747	1343	69	349.50	26	75.79	CHANGED	EhsuFhpLapRYlsc..spspplcWDcIcpPs.--ll.....cY-pLpt.s....pphuplLsKLAVLKLNGGLGToMGCpuPKSlIEV............RsshTFLDLtVpQIEpLN+pY.s.ssVPLlLMNSasTcc-TpKllcK..Ysss+lc.IpTFpQSpaPRlsKDoLLPlPpts..sS.s...-tWYPPGHGDlFcSLhsSGhlDsLLAQGKEYlFVSNlDN.LGAoVDLpILNHlIp....ppsEYsMEVT-KTpADlKGGsLhoY-G+l+LLEluQVPpc+l-EFKShpK.....FKlFNTNNl...WlsL+AlKRLl-sspLcL-IIsN.Kpl...s...........cslcllQLETAhGuAIppFcsuhGl.pVPR.sRFLPVKoo.SDLhLlpSsLYsLc.sGolphsstR.t.ssPll+LGsEFpcVusahpRlsuIP.sllELDHLTVSGDVaFGpNloLK	.....................................................................................................................................................................................l.................t.tt.h..s.....+huVlhlsGG...............GTph..G..h.ps.P..K..u.h..h..pl..............................t..p..t.hoh....h.p.....l.......s.p.p..l........t......p.......l......p........c........p..........h.......s.....s.......s.......l.P...h.hl.M..sS....Tcc...........s..Thp...hhc..c...........Yh....s...........h...p.hc...........lh.hFp.......Q.s...p...hPt.l.s.t.-u..hl.ltp.............ps.......s..........................t...............PsGpGs....lapuL........h........s..............u.......G.......h...........L....-c.......h.hpp..G..h.c...a.l.alt........sl.DN....Ls.ts....sD.h........hluah.....hp..............p..s....s-h.s.hc...ls.t+s...pss...tpsG..h..l.s...........p.....h...............-..........s.......c..........hp.............l...lEh...u.p.l..st..c........ht....th.p.s...pt.................hhh.F..N.s...s...Nl........ahsh...thlp..p.l........h..........p....t.......t..h..p...h..h..hh..s.K...p....l......c........................ssh.t.lh.....p.....h..t....h.......hh...hsl....h.a..........t.........p...s.h..........s...........l..pV.sR....pcF.PlKss.................................................................................................................................................................................................................................................................................................................................................	0	291	446	619
+4787	PF00201	UDPGT		UDP-glucoronosyl and UDP-glucosyl transferase	Finn RD	anon	Prosite	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.60	0.70	-5.95	14	8949	2012-10-03 16:42:30	2003-04-07 12:59:11	13	81	1315	25	4768	9465	106	279.00	18	62.32	CHANGED	GKVLVaPh-hSHWhsh+sllccLlpRGHElsVLtsuuohhlc.tcsuslphcsassuhopc-lcs.hhphhpphhhthsp.sshhphhsthp....chushhtssCpplltNKpLhppLpESpFDVlhsDslhPCGtllAcLLpIPhVa.LRhsPshhhp+tstth.hPsSYVPhllosLSDpMTFh-RV+NMlhhLhhcahhphh.pp.asphhSElLsRPsTls-hhu+AshWLlRshash-aP+PlhPNhsFlGGlpC+PAKPLspEhEtalpuSGE+GlVVFSLGSMVSshsEE+AphIAsALupIPQpVLWRacG.....p+PssLusNT.....hLhKWlPQNDLLGHPpT+AFlTHuGusGlYEuIppGlPMVshPLFGDQhDNht+MpsKGAuVoLNhtpMoSpDLhNALKsVIND.sYKENhMpLSplH+DpPhcPLDhAVFWlEaVMRHKGA+HLRsAAHDLTWaQYHSLDVIGFLLusVsslsFlshKsChasaRKhltttp+s	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p........................................p.u..l..l.h....luh................G........o..h...h....t.............s......p......p...........h........p...t..l.....h.......t.....u....l.......t.....p...............s.....t...........t.....h.....l.......W.....h......h...p..s.............................................t..........h.......t......p......s..h..........................hl..h...p....W.....h.....P......Q..........p..........l..L................s..................H.......s.................t................s.t.s..Fl.o.H.s.G....h.......s.S....s.h.E.ul..h..t.G.V.P.h.l..s...................h................P....h.....h.....u......D.....Q..........h.N....s.t.........h............h...........t...........p...........h...................t........h..........u........h........................h...............................t........................h..........p.....t.....t.....t......l......t...t..l..t...t.l..h......t...t........................................................................................................................................................................................................................................................................................................................................................................tth.................................................................................	0	1059	2520	3921
+4788	PF03152	UFD1		Ubiquitin fusion degradation protein UFD1	Mifsud W	anon	Pfam-B_3272 (release 6.5)	Family	Post-translational ubiquitin-protein conjugates are recognised for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified [1]. This family includes UFD1, a 40kD protein that is essential for vegetative cell viability [1]. The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterised by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated  with these conditions are thought to be due to defective neural crest cell differentiation [2].	35.60	35.60	36.10	35.70	35.00	35.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.95	0.71	-5.13	37	579	2012-10-01 20:15:13	2003-04-07 12:59:11	9	16	320	2	392	551	43	168.30	40	42.35	CHANGED	papppa+sYPluhh....c+p..plppGsKIlhPPSALscLsp....lpl..p.aPMlFcLp...Ns........psp+hTHsGVLEFlA-EGpsalPhW........................MMpsLtLpcGsh.....lplp.sssLPpGsalKlpPposcFLD..IosPKAV.LEssL.RNausLThGDhItIsYssppYtlcllEl.....KPss....AlolIETD.....lpVDFssP	....................................p.apt.apsashshh..............p+....phphGsK............l.hhPPSALcpLsp.................................Lpl....p..aPM..lFcLp.......Nt.........................ps.s..+hoHsGVLEFsA.-.E.Gp..saLPhW..............................................MMps....L.hLp....pGsh.............................lplc...ss.sLPhuoalKLQP..p.oss....FLD......I...os...PKAV..LEssL.R.N.F.us.LTpGDlls..l........s...Y......N...s........c.h.Y.c...l..pVhEs................KPss......ul...sll.ETD.....h...pVDFssP..............................	0	134	226	333
+4789	PF02512	UK	UK_protein; 	Virulence determinant	Mian N, Bateman A	anon	Pfam-B_2106 (release 5.4)	Family	The UK protein is an African swine fever virus (ASFV) protein that  is highly conserved amongst strains, and is an important viral virulence determinant for domestic pigs [1].	25.00	25.00	176.40	36.90	20.00	17.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.18	0.72	-10.40	0.72	-3.60	7	23	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	9	0	0	19	0	88.40	80	101.25	CHANGED	MSTHssSPKEKPVDhNNlSEKsuVVNNAP............................................................EKPAGANHIPEKSA.cMTSSEWIAEYWKGIKRGNDVPCCCPRKMTSADKKFSVFGKG.LMRShQKss	...........MSTHssSPKEKPVDMNsISEKSuVVNNAPEKPAGANHIPEKSA.EMTSSEWIAEYWKGIpRGNDVPCCCPRKMTSADKKFSVFGKG.LMRShQKss......	0	0	0	0
+4790	PF03044	Herpes_UL16	UL16_UL94; 	Herpesvirus UL16/UL94 family	Bateman A	anon	Pfam-B_4392 (release 6.4)	Family	This family groups together HSV-1 UL16 Swiss:P10200, HSV-6 ORF11R Swiss:P24442, EHV-1 46 Swiss:P28970, HCMV UL94 Swiss:P16800, EBV BGLF2 Swiss:P03221 and VZV 44 Swiss:P09293. UL16 protein may play a role in capsid maturation including DNA  packaging/cleavage [1]. In immunofluorescence studies [2], UL16 was localised to the nucleus of infected cells in areas containing high concentrations of HSV capsid proteins. These nuclear compartments have been described previously as viral assemblons [3] and are distinct from compartments containing replicating DNA. Localisation within assemblons argues for a role of UL16 encoded protein in capsid assembly or maturation [2].	25.00	25.00	42.80	42.80	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.20	0.70	-5.45	31	277	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	92	0	0	130	0	223.10	36	94.79	CHANGED	Ms.........tsthphl+pFLpcEClWhh.lssssph+lYpussshSshh...........tss.sssspslplplhlh+P+t.....pphhlslhlNGthh.....sssphchhhsptl.t.sphhllhFuslsssshsh..lPs.ss.pss..ssttls.stlhpsup..hl.sp-shsssshu............h.lG.sGAWh...p.ustslYhahls.DLhshCPsh.phPSLu+llsthssCcstt....Cs.Cpspt.tHVsshsshssssss..ussC.ChsPCthhcus....lslpuppsLhsllF.-sphthplsthpttpsslssslscllsGhsssGcplssssssWpLlplsshhSRhhlhuC.sLK+	...........thss.......phscRLLNDVsVWsp.VRsDshLpIhoAphsLppchp......ttspsss.ssssusLcIaLYLTKPKp.p.tp+ssHITslVNGs+A......hshLp+hssc+oPhG.uchashplu+sphsPsPhE.lPDPpsEP...........................................................................................................................................................................................................................................h.......	0	0	0	0
+4791	PF03252	Herpes_UL21	UL21; 	Herpesvirus UL21	Bateman A	anon	Pfam-B_3264 (release 6.5)	Family	The UL21 protein appears to be a dispensable component in herpesviruses [1].	25.00	25.00	56.20	56.10	18.10	17.20	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.73	0.70	-6.03	14	85	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	38	0	0	74	0	424.90	37	97.05	CHANGED	MEhpYpsslta..psVsFYlsssGsRAYFlCGGClhSVsR.....ttpsuElAKFGLsLRG.G.sD+slAsYVRoELtR.pG..hphuhPsscc-.....VFlDslulL..............s.ss...usEtDLCGth-lEVhDPtLA-ahVSLpsosGLllssuccpsp-+ll+LacsPslsNssSsFlYsPNpssFsLsQApLscLPsuLpsLVcGLFDsIPs..............sRpPlstps...ppT-VIlTupRAApsh............................hstttptstpst++sslSsFVQV+aI.......PRVhshWsspusss.................sstoLpcLhplhhtsDtllhcs........pthsGlspchspA..+sslsptstslFGptut.hsFlGt.....tshslossQ+FsLhQYllp+tchssCYshLccLscsYhss..pcssss..Dpt................sluDssNslhR-sshlGtsuEtllthshhpsth......................ssssupssps-ussLLclApsphth..s.........ssshppp+htcluthLstLYsGtshhsuAhphuchhGsuthlsshh-sphhoAF-cussu....p+hstYLtuLls	.............M-htYtpshha..psVhFYlststpRAYFhpGGClhSlsR......tpssElAKFGLslRG.u.ss+slAsYVRoEL..tppG.....ht.shs.spp-.........VFlDslslL..............t.ss...ss-hDlhst.-lEVhD.hLsch.hsSL.sssslhlssstshsp-phlcLhthPslss.ssStFhYsss..sFsLspApLscLPtSLp.LspGLFDslPs..............sR.sLsscs...p+TslllTupRAAcsl............................hsptpsptt+tt++sslSsFVQl+hI.......P.RVhshWsspttss.....................s.slptL.hlhhhuDcllhcs........pt.sG.LpcE...scA..ppslhptshslaGptGt.hsFhGt......uhsLoshQ+FslhQYIlpR.chhsCYsslccLscpYspt..psts..ss.ssps................hlsDssNtlhRcshhhG.hsc.lh.h................................sut.s..-uthlhchhtt..................shs.t..h.h.luhhLshlYtstshhssAh..sphhsss..lhhh.ph..hoAF-...hh....t+hhthl..Lh.h...........................	0	0	0	0
+4792	PF01499	Herpes_UL25	UL25; 	Herpesvirus UL25 family	Bateman A	anon	Pfam-B_700 (release 4.0)	Family	The herpesvirus UL25 gene product is a virion component involved in virus penetration [2] and capsid assembly.  The product of the UL25 gene is required for packaging but not cleavage of replicated viral DNA [2]. This family includes a number of herpesvirus proteins: EHV-1 36, EBV BVRF1 Swiss:P03233, HCMV UL77 Swiss:P16726, ILTV ORF2 Swiss:P23987, and VZV gene 34 Swiss:P09287.	25.00	25.00	50.40	50.30	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	540	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.52	0.70	-6.20	15	156	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	90	1	0	140	0	513.80	29	94.47	CHANGED	hthhhts..hh.scs+Nhltsshsshphsp.phutphRspt....phchsph++c..hlpAELDsLttpptstssplsscLcslEp......tltchsps.sslp...............................ssspusppssssps...hs.hstspsssh...............pVsIs.sDPslpacsshps-hlsslYsspupWsso....FGsWYtsLpcshhpcRhhP+sh+ussstssohStcLMssslssLpussphahuDppahuDpsAALCLlsAYh.....utpsus.hP....sohs-LLppLPphlchLss-lpstps..usssapFshsc.sppphhuPhs+tt+YspssFssHtlhshLh+tGVlsthsGt...........scssGsshsD.-lsh...slsshlhusslPhhsccQhhLRuGlsuIpuLlLlapLLpsusVasc+ss+phpLuuLls.sthssss.......ss.utpssshpt............spNFpFLhccYVlPhYptsspsslopLFPGLsuLslstpsttussstpt......hlslous+aQ.....slhcllstcLpp+cs.......stllsAHDuLtlphEcGLulLLppspPppu.hpshtpuQFsV	........s........hhh.scscN.hltss..hhhhhp.thshshcstt...pphthtps++p..hhtstL-sLtt....pttshst-lcp+lcslEp..........................plpph.sssh.....sshp................................................ps.stssptsssuts....tt.ssstssss.tsts................................pltIspNDPsl......pac.oshps-llshlYsspsshsso.....FGsWYtpLpcthhsc...PpshRhsphcssphSpphhssslsuLpssshhhsssp.h.u..pAsLCLhhhYt.............shtss..p.phP.....sohtpLlppLPphl....ctls....ppls....s.....p.......stsshtashpc.Pctpahs.Phsp...YptGshspHsllthLh+puVlsthPG...t..................t..st.phsssstsD.clsh....thsshhht.tps.hhhc-QphLRuslsslsuLlLlh+LLtsssVa.us+hsphhpLuslls.sssssts......sss.stptsh.ht..u...............................tspNFpFLhppYlsPhYttsPs.lplopLFPGLshLslstp..st.....p..shsssp+...............slshuusthQ..........tslhchhhhph.pp+pt.......hcllpsHDulhhpaEpGLGhLhp.shstpt.hpsht.stFNV......	0	0	0	0
+4793	PF04496	Herpes_UL35	UL35; 	Herpesvirus UL35 family 	Finn RD	anon	Pfam-B_3981 (release 7.5)	Family	UL35 represents a true late gene which encodes a 12-kDa  capsid protein [1].	25.00	25.00	27.80	28.20	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-9.97	0.72	-3.80	11	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	30	0	0	30	0	99.00	38	74.64	CHANGED	ssFDPssPsThos-slpshs.VsLlphLNss.tslpsusptsp.lssA+psllhGtusuhsclR+pHsspTlpRssMFApsDsuoWlRPolGLKRTFsPtlhp	......sFDPssPsThos-slcshh.V-llhtLNss.t.lpsspptsthhpsA+pslhhGtusuhsclRppHsspTlpRpsMFAssDsuoWlRPolGLKRTFsPtlh...	0	0	0	0
+4794	PF03970	Herpes_UL37_1	UL37;	Herpesvirus UL37 tegument protein	Finn RD	anon	DOMO_DM03155x;	Family	UL37 interacts with UL36, which is thought to be an important early step in tegumentation during virion morphogenesis in the cytoplasm [1].	25.00	25.00	30.40	30.30	18.60	17.80	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.76	0.70	-5.59	9	82	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	33	0	0	78	0	264.90	37	25.28	CHANGED	stspshshpsLLssLtuL........upsssstcshssthsucsRsuIupFhhSosplslppscshW+cLhp...slhclYppot.PEAAhLAcNhsGLlhWRlslpWscs..phh-phcpL+plshthTupEslphLopNsLRhSAshGPsshp.hlo-WhshFcssspsshshoscshhpuRt.h........ltphsAuLsppRFsLIYDhPFVQEGlRlluttssWlsPFslhhpphpssshT..PLTRsLFhluLlDpY.hssssssp.....Lp-hFs-slptls	.....................................................................................................s.s.phshppLLssLssL........sppsssscs.u.htsuchRuuhutFLLSssslsstcsctpWc..sLhp...tlCtlapspthPEsAhLAENLPGLllaRLslshscs..pshcphchlpchlhshsus-s.ptLssssLRsuAshG.PVph+thls-WlspapslscsshshsPcs.hcAhttts........lspssAsLsp.tauLlashPFVQEGlRhLuhsushls.FsshhpplssuoLT..PLTRALFTLuLVDEY.hsssptss..s..LhttFtcsVptIc.................	0	0	0	0
+4795	PF02282	Herpes_UL42	UL42; 	DNA polymerase processivity factor (UL42)	Bateman A, Mian N	anon	Pfam-B_5119 (release 5.2)	Domain	The DNA polymerase processivity factor (UL42) of herpes simplex virus forms a heterodimer with UL30 to create the viral DNA polymerase complex. UL42 functions to increase the processivity of polymerisation and makes little contribution to the catalytic activity of the  polymerase.	20.80	20.80	20.80	25.70	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.76	0.71	-4.63	12	135	2012-10-02 11:47:48	2003-04-07 12:59:11	11	2	32	8	0	135	0	137.10	27	63.67	CHANGED	sphsLsctpLsclhushts.ssshtssFhlhsccshhlpsshtupplhhslptpthsph.......ss.tlhLu.s-uppsLl..hthspt.psht............phshtlcspsshRpLlQplhhssst..........ht..hss.sss.hslhppp.sshshhh	.....................splsLpcspLscllsuhus.tss....hhsohhlhsstshhlasohhuppVhhslcpsthSph.......ss..h..u.scuppsLl.shthspt.psst............phslslsspsshRsllQ+lhsssut..............hss....pssuhslhtpt.suhsshh......................	1	0	0	0
+4796	PF03117	Herpes_UL49_1	UL49; 	UL49 family	Mifsud W	anon	Pfam-B_2110 (release 6.5)	Family	Members of this family, found in several herpesviruses, include EBV BFRF2 Swiss:P14347 and other UL49 proteins (e.g. HCMVA UL49 Swiss:P16786, HSV6 U33 Swiss:P52441). There are eight conserved cysteine residues in this alignment, all lying towards the C-terminus. Their function is unknown.	25.00	25.00	53.80	52.70	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.04	0.70	-5.28	16	80	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	52	0	0	75	0	247.60	42	50.98	CHANGED	hsspspuLlsAL+ppussVPCGNPh.sMs+sLshpsshpss+sllPlspp........................................................ssplspplhsplLuhslLusllslPlhshsht+shRtttsts.......hhsVlCt-CGHCLNhGKsKhps...hsFsPosh.FYsRDpKEKphhhCssoGRlYCShCGSpplpshplhEhs...h.hGh..shl..RAVlusNAAhslpssspphDlllPChuostsCtu.slL+clolpcLLhLT..upssphhCt+Cps	.......s..phpuLluuLRccuupVPCGNPlasMs+thlppaCtsssRaLlPlpshsht.tsp.......sts.........................................h..p.s+lshaulussLRsGLluSVI-LPlhChs+hKCpRahcsts........lhAVVCppCGHCLNhGK-KLcsp..psFsLNSh.FYYRD+QEKuVlassps-hlHCSLCGSpplspp+lYElsptshhGt...hpVp..W+AVlG.NAACulhstphthDlllPC..usRoC.usVllRtloV.+LLpLT..SHupshhCt+CQ....	0	0	0	0
+4797	PF03121	Herpes_UL52	UL52_UL70; 	Herpesviridae UL52/UL70 DNA primase	Mifsud W	anon	Pfam-B_203 (release 6.5)	Family	Herpes simplex virus type 1 DNA replication in host cells is known to be mediated by seven viral-encoded proteins, three of which form a heterotrimeric DNA helicase-primase complex. This complex consists of UL5, UL8, and UL52 subunits.  Heterodimers consisting of UL5 and UL52 have been shown to retain both helicase and primase activities. Nevertheless, UL8 is still essential for replication: though it lacks any DNA binding or catalytic activities, it is involved in the transport of UL5-UL52 and it also interacts with other replication proteins. The molecular mechanisms of the UL5-UL52 catalytic activities are not known. While UL5 is associated with DNA helicase activity and UL52 with DNA primase activity, the helicase activity requires the interaction of UL5 and UL52 [see 2,3]. It is not known if the primase activity can be maintained by UL52 alone. The region encompassed by residues 610-636 of HSV1 UL52 Swiss:P10236 is thought to contain a divalent metal cation binding motif. Indeed, this region contains several aspartate and  glutamate residues that might be involved in divalent cation binding. The biological significance of UL52-UL8 interaction is not known. Yeast two-hybrid analysis together with immunoprecipitation experiments  have shown that the HSV1 UL52 region between residues 366-914 is essential for this interaction, while the first 349 N-terminal residues are dispensable [2].  This family also includes protein UL70 from cytomegalovirus (CMV, a subgroup of the Herpesviridae) strains (e.g. Swiss:P17149), which, by analogy with UL52, is thought to have DNA primase activity. Indeed, CMV  strains also possess a DNA helicase-primase complex, the other subunits  being protein UL105 (with known similarity to HSV1 UL5) and protein UL102.	20.80	20.80	21.00	20.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.84	0.72	-4.24	38	329	2012-10-02 15:26:12	2003-04-07 12:59:11	10	8	214	0	89	310	49	69.60	23	8.88	CHANGED	shtpsshhllplp.........+spsFtClphpHppp.pps...........splalslpssp.ttlhhshhppCF........usK.........CssNphpsthoshss	..............h..pthhlhplt.........p.tshhChpht+t+pups..............lalslchpp.....hshhQ+Ca.......ssc.........Cpspthps.h.....s....................	0	37	49	70
+4798	PF03049	Herpes_UL79	UL79; 	UL79 family	Bateman A	anon	Pfam-B_2433 (release 6.4)	Family	Members of this family are functionally uncharacterised proteins from herpesviruses. This family groups together HSV-6 U52 Swiss:P52469, HVS-1 18 Swiss:Q01003 and HCMV UL79 Swiss:P16752.	20.50	20.50	20.70	21.70	19.90	16.20	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.43	0.70	-5.31	19	61	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	50	0	0	55	0	246.10	36	92.22	CHANGED	hlG+alh.pspshoshlhplhhKllpGpsLsohp.-EL+hl+LlhsphashGLplhLLREslsNsGspDsslLsRKVPsEaWphlY-shcphssssc...hLhsEsptupLhh+Ls.pssslhphlspalhpchGL..tlplssp.lpDGNhLFsLGoVhspRLlhlhtFhhhaWGppphEPhVRhhspKlahhYLIlsG+Lplptshap.psssphsGlhphlhpDhhuapG....slspss.............h.p.tp.hDh..lhlhsssl	...hG+al..phsshsphlhpIhpKhhpGpsLsoh+.EEL+ll+LlhshhaphGLpshLLREshsNsGlsDssVLuRKlPspaWhhlYctLcphssstc...hlhsEspuApL.h+Ls.ps.th.hthlscalhcchGL..slslsp-hhpDGNlLFsLGolhsaRLhhlstFhhtaWGpppaEPhlRhhspKhahhYLIhsG+lpls.ssap.ppopc.sGlhshIhcDh+sFtG....slstps.phhp.pp.........................	0	0	0	0
+4799	PF03043	Herpes_UL87	UL87; 	Herpesvirus UL87 family	Bateman A	anon	Pfam-B_1736 (release 6.4)	Family	Members of this family are functionally uncharacterised. This family groups together EBV BcRF1 Swiss:P25215, HSV-6 U58 Swiss:P24437, HVS-1 24 Swiss:Q01007 and HCMV UL87 Swiss:P16730. The proteins range from 575 to 950 amino acids in length.	25.00	25.00	25.40	25.40	24.10	24.70	hmmbuild  -o /dev/null HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.86	0.70	-6.12	19	90	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	54	0	0	80	0	494.10	43	72.04	CHANGED	tLht.hpssp..........hshhP.hssspsththtcF.lLphhptW.s....Nsshtchtpplhpslpppsthlhhhh+hssppslplpshslhcapptl.hhh.p.lphpppK+tst.tshthslsp........ppthltasss..sslaRshhsh....................................................................................................usucplspspsshp.ssptss.......................sRthVshhcRlpaAP+ct............................................shshththp....................phpspsttp.shtppFsslsplSls.sF+VNlFNTNhVINTKlsspptss.....pslhslP+.LTpNFVh+KaohKEPuFTVSlFaSsDhs.pssAINlNIsGshlpFLaAhush+CalPIcslF.PAuluNWNSTLDLHGLENQslVRssR+cVFWTTNFPSslSspcGhNVSWFKAATAsISKlpGpsLpsplh+Els.IlshppAplshsKNplFThLEpRNphQIQsLHKRFLEsLatpsuhLRLs........s+slh+lsppGlFDFSK+hlAHoKsKH-CAL..lGh+hsNslPKllspsKKhRLDcLGRNANaLohh+psspp...hsth+tpll++ll+pLu.....l+p+	...............................................................................................................h.....ht.p..........hshhP...s.hs..t.hcF.llph.p.Whs....ptshtchhtplhtphpp..thlhhhh+.stppshtlpthsh.capptl.hh....p.lphtpp+p..............t.hcshlhh........pph.lhassp..sslaRslhhh....................................................................................................uhst.hh.sps..t...........................................spthlthhpRl.as.ht.............................................shs....hth........t............pt.s.sttp..hs.pFs.hptlols.phtVNsFNTNhVINhKhshpphst.....hph.plP+.hTpsFVhhKaohKEPuhTVSsFhSsshs.hhsulNlNIpGsh.cFLauhush+halsIcphF.PAslsN.NSoLDlHGLEsQsllRstRpcVaWTTNFPshlSppsslNVGWFKAATAIlP+VSGssLEslLLKELshIpshcplslDas.LHRlFThLEpRNsYQIPFLsKQhl..LFlRsshL+LpGhtpc..lc+hlhcAspcGlFDaSKphhuHTK.KHpCAL..lG.RhsNslPKllspsKKh+LDcLGRNANhLohh+phttt...hsth+hpllhcllttLt.............	0	0	0	0
+4800	PF03048	Herpes_UL92	2111; UL92; 	UL92 family	Mifsud W	anon	Pfam-B_2111 (release 6.4)	Family	Members of this family, found in several herpesviruses, include EBV BDLF4 Swiss:P03223, HCMV UL92 Swiss:P16798, HHV8 31 Swiss:P88920,  HSV6 U63 Swiss:P24440. Their function is unknown. The N terminus of this protein contains 6 conserved cysteines and histidines that might form a zinc binding domain (A Bateman pers. obs.).	20.50	20.50	20.50	20.80	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.51	0.71	-4.73	18	82	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	66	0	10	71	1	162.60	28	70.67	CHANGED	pCphpplpsslTphpslsslYhCspCtcYHVCDGu.p-CsllsTtEGhVCthTGpshssslpsssthsspshpcsp...tphp.p.hhNllpslhpclhpYhppsss.hsclppplh.scGpLpccltslIphTFscChplhsshpps..hsllsSlYIHlIISlYSs+TlYsshlFKsT+NK+aDsllKpMRppWMssL	..........Cphpplpsshs.p.hpltslYhChpCtphHlC.Dts.ppCslls.T.tEu.hVCshTGhshtshhsssp.h.h.pshppst....p.......shltslhp.lhpah.p.s..hstlhpplh.ptsthp.pltp.l.hTFtpshp.hpth..pth..hsllsphalplIIulauptThYsshlhKso+pK+.DslhKphR.tahss.s...................	1	2	8	9
+4801	PF03038	Herpes_UL95	UL95; 	UL95 family	Mifsud W	anon	Pfam-B_2060 (release 6.4)	Family	Members of this family, found in several herpesviruses, include EBV BGLF3 Swiss:P03220 and other UL95 proteins (e.g. HCMV UL95 Swiss:P16801,  HVS-1 34 Swiss:Q01023, HSV6 U67 Swiss:P24444). Their function is unknown.	21.60	21.60	22.30	23.20	18.70	21.50	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.11	0.70	-5.57	20	82	2009-09-11 15:08:21	2003-04-07 12:59:11	9	2	52	0	2	72	0	333.20	36	87.25	CHANGED	MhsLsphp..scscsphsc+YpcuVcLALshCEus.P.sQFKLIETPhsSFLLVTNVlPc-ssshsstss..............................pthchpslphs+hpthptlhshphpsstpptsssss.................hhp.psphhtssYllYcppphphALshNKssllppsLchlssPspWsappssDPLslLWLLFhGP+SaCpcssChhtc+hGp..PGPlLLPPhhYcPspDlpoFhshsppYVhshYpch..................................................us.h.shshsPFchsRl+cslppl...schsspslhl....S+pCLLCsLY+QNph....uppss.ssshu.hIILsstutphhso.....htsp+pssousslLaPsYslssLlsslstsssu	..................................................................................Mhtlst.p....schsst.shRaccuVphALssCEus.P.-pF+LIETP.psFLLVTNllPc-ps.h.shss.................................pt.phpphphsc.sths..h..hcppsshpthsssst..............ss.t.hs.psphhhssYllYpKpphchuLo.NKsphlptsLc.lhsPshhsapsspDs.slLWLLasGP+SaCtcssChupc+tGp..shPsLLP.hhYcPspDh.oahshsphYVashYcshch..................................................u..p.h.ph.hhPhshsRl+cslptl...tchsscplsh.....SRsCLLCsLYpQNcl....Appcs.sssauPllI.sstushp.lo......hoahhPupssssLaPsYclupLlssls.sptu.........	0	2	2	2
+4802	PF04817	Umbravirus_LDM		Umbravirus long distance movement (LDM) family 	Finn RD	anon	Pfam-B_5103 (release 7.6)	Family	The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants [1].	25.00	25.00	33.60	33.10	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.44	0.70	-5.22	4	24	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	8	0	0	24	0	226.80	42	93.30	CHANGED	MoSlINV.ssuKSppscGsstSSVRtGcpptsPtsKPtusHssSR+sKGssHPAsTsKcsppslpuspAsssHpcHtGssl.tEusGuVHssRstRRuRRuGuMcsRQ.TsQPppRtscsch.sERRAplDGLLPPLLDTlsGph.GsAtlLhaCltAl+RpLRp+h.cPlQsspcVAuopGcsssQLs-puspsutsLssDGtGRAstus..psl.pGusV.pVCssCsts	...............MoolINV.ssscu+psRGsspsSlRtGcpctAttsKPtsspsPsRRppGGsaPusss+cspcshptspssssHppHtGoslhREusGGVHssRstRptRRuushuPRQpsssP+QRhApsclssERRAplDulLsPLLDTlctpspGsAslLLaClsAlRRELRc+h.cPVQPsHsVuuoptppusQL.-puspssssLpssGcGpustss.ppslpptssV.pVCssCsh.s..............................	0	0	0	0
+4803	PF00021	UPAR_LY6		u-PAR/Ly-6 domain	Sonnhammer ELL, Bateman A	anon	Prosite	Domain	This extracellular disulphide bond rich domain is related to Pfam:PF00087.	17.70	10.00	17.70	10.20	17.60	9.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-10.76	0.72	-3.56	40	1221	2012-10-03 01:43:02	2003-04-07 12:59:11	16	8	118	68	543	1327	0	74.40	20	55.41	CHANGED	CasCht..tspsCpss.....sCstspsh....Chsspsth..ss...psphhh+sChp.stC.........ph.shthphstsslph...........sC.CppsLCN	......................................ChsC...ht....s...sts......Cpst.......hpCss.s..psh....................Chs.....s..p....s.....p...h.t..........s..t........t.s.ph.hh+..uC..s.......stC..............p........t.h...s.......h...p...h...ph..................pC..Cp.tshCN.............................................	6	39	65	185
+4804	PF00919	UPF0004		Uncharacterized protein family UPF0004	Bateman A, Moxon SJ	anon	Pfam-B_1257 (release 3.0)	Family	This family is the N terminal half of the Prosite family. The C-terminal half has been shown to be related to MiaB proteins [1,2]. This domain is a nearly always found in conjunction with Pfam:PF04055 and Pfam:PF01938 although its function is uncertain.	21.30	21.30	21.70	22.20	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.67	0.72	-4.16	160	8275	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	3943	0	2232	6265	3365	97.10	32	21.38	CHANGED	+lhlhThGCphNhhDSEhhtuhLppt.Gaphssp...c.cADllllNTCulppsAcpcshppltchpchc............st.............................thls...........VsGChuQpts..cclhcths..hDhllG	.....................lhlhThGCphNhh...DSEthhshL..p.s.t........G......Y....p......h........s.........s...s..........c.....c............A.....D..........ll..llNTCulp-pAppcshptlsc..htphp................t....................................................................................................................................hhl.s................VsGCh.up.pps...c..p.l.h.c.p.h.s..VDhlhG......................................................................................................	0	840	1539	1927
+4805	PF03649	UPF0014		Uncharacterised protein family (UPF0014)	Bateman A	anon	SWISS-PROT	Family	\N	20.50	20.50	20.70	22.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.77	0.70	-5.22	3	1867	2009-09-14 12:52:49	2003-04-07 12:59:11	8	5	1800	0	366	1096	131	235.30	37	93.21	CHANGED	hpHsllpL.ht-LuaALhLVllAILIua+EKLuLEKcILWuuGRAIIQLIIVGYVLtYIFSlDsssusLLMlulMlTlAAalAp+RINh+uKohlu.aLaITlGAoThISL...AVLIIssslcFpPhYVIPLsGMIlGNTMNoluLAh-+LustVpSEpcpIps+LuLGATPtQAlAsaIRsAIRAALIPTVNpsKoVGLVSLPGMMoGhlLAGuDPlpAucYQIlIMFMILSTAoLSTIllCYLsYRcaaNu	.......................................s............sLsl.uh..h.L.....l.l.l.s...l..h...lS.h...t...p...+L......ultK-llhushRAll....QLlll.Gal.Lp.Yl.F.p..l..s..s.h.hl.s..l.Lh.l..lhh.hh.sA.u..a..s..s.....tpR...u.....p.....h.....h.....h....+...s...h...h...............h...l...u...l.s..l..s..s...u.............l..s...L......sl...l....l....l..s..s.sh.....a.tP.t..tlIPIuGMlhGNuMsA....luLshppLtpphpp.c....ppplpptLuLGATs+pAutshl.Rcul+sullPTlDSs+Tl.GLVSLPG..MMoGlIluGssPlpAI+YQIhVh...Fhlh.uss...ul.o..sll.A.s.hLsY+paas........................	0	125	227	309
+4806	PF01169	UPF0016		Uncharacterized protein family UPF0016	Finn RD, Bateman A	anon	Prosite	Family	This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.55	0.72	-3.84	145	2676	2012-10-03 02:02:08	2003-04-07 12:59:11	14	8	1140	0	1249	2385	333	76.00	30	60.26	CHANGED	a....h..sohshlhlAElGDKTQlsslsLAuth.tpsh.sVhhGsslAhhlssslulhh.Gphl.......sphls.p..hlphluullFlhhG	..................htohshhhlAElGDKTQlsolhLAuca..........s.....h...sVhhGshluhhlsss.....l...ulhh.G.ph.l...........ushl..s.p......hlphluullFlhhu...............................	0	407	768	1060
+4807	PF01170	UPF0020		Putative RNA methylase family UPF0020	Finn RD, Bateman A	anon	Prosite	Domain	This domain is probably a methylase.  It is associated with the THUMP domain that also occurs with RNA modification domains [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.09	0.71	-4.70	16	3872	2012-10-10 17:06:42	2003-04-07 12:59:11	13	26	3399	14	1064	14743	3401	195.00	31	40.56	CHANGED	RsaRsastPusLpssLAtAhlpLushpsspsllDPhCGoGTlhIEAALhutphh...........................................hGsDhct+hlpuA+hNsppsGlschlphhphcsspLp...hss....ps-sllosPPYGh+lupptsl.ppLYpphhcph+chhps...hhshhhspppshppshppt..shcththhplthushpht	...............................................................................................................................RGYR....t.p.Gt...APl+.E.s.LAA...ul.l........h....h...........o........s....W..........p............s..........s...........p.........s.........l...lDPhC...GS...G..T...l..h...I...E......A..A...h.h.u.t..shAP.GhpRthhh.ph..............................................................................................................ttttttt.p........php.....hh..G....s.....D....h...D..s......c...h....l.......c.......h.........A......+............p........N.........A.........c.......p.........A............G.......l...........s.......c...........h..........I.............p..........a........p.....t....h......c...l....p....p...lp.....................spt.................thG...s.....l.l...s....N..P....P...Y...........G.....E.......R....l.................s.................s........c..........t.......t........l...................t.L........Y......p.....t.h....G...p.h..h.cp..hts..........hphh.lh..o..u..p......p..h....p.h.hthp......us+ph+hhNG.lcs..........................................................................................................................	0	349	629	868
+4808	PF01171	ATP_bind_3	UPF0021;ATP_bind3; 	PP-loop family	Finn RD, Bateman A, Yeats C	anon	Prosite	Family	This family of proteins belongs to the PP-loop superfamily [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.14	0.71	-4.79	33	7781	2012-10-02 18:00:56	2003-04-07 12:59:11	15	37	4816	13	2118	7133	3921	174.70	26	46.74	CHANGED	phllAlSGGsDShsLLhlLtchttp..h..........plsslHlcHslR.p.pucp-tpalpphCpphs..lslhltphsh......st.....tpslEptARchRYchhpchhtppshphllhAHHtDDQhEThlhpLhRGsuh.....tuLsu..hts.....tp.h........ts.hpllRPLL.shs+p-l.pascppplsahcDpSNts.pYp.RNplRpp	................................................................lhlulS.G.GhDS..h.s.LLp..lL...t...p..h....p..p...p.h.sh...................plts..l...p...ls....a...s...h.....p.....t........t.....u........t.t..........t...p..hl..p.p..h.s.p....p.h.s.............l..s.....h...t.l.hp..hsh............................t..t.....s.p.s.h.p....s.....h.......u......R........p.............h............R..................h...........t...........h...........h....t.....c....h.....s..............p...........c..........h......s........h.....s...............t.............l....shu.H......H..t.....D.......D.th....E.....T.h.lh.....s..l.h..+.G..u.th............t.s.l.t....u...hs...........t.p..................................................................ts...hhl...lR...PL..l.........hh........p.c.p......-..l....h....p....a............sp..........t.....p........tl.........h..h...D...s....s....t....h...R.............................................................................................................................	1	734	1357	1799
+4809	PF01172	SBDS	UPF0023; 	Shwachman-Bodian-Diamond syndrome (SBDS) protein 	Finn RD, Bateman A, Moxon SJ, Mistry J, Wood V	anon	Prosite	Family	This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.  It is characterised by bone marrow failure and leukemia predisposition.  Members of this family play a role in RNA metabolism [2] [3].  In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes [4].  This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition [4].	24.40	24.40	25.50	27.00	20.00	24.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.81	0.72	-4.19	103	652	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	473	7	444	614	94	91.60	36	38.64	CHANGED	ssssll+h+.p...tGc+..FElllhsspshpa+.........pGp..........phsls-VltspplFpss...s+Gpp.....AucppLppsF.......G.Ts-hpclhcpILc+GElQloscpR+ph	.............................ssslVRhK...p...tGc+....FEl..hs..a....s...c...l...hpaR.........sst.................-tcL--VLps.ppVFtss....uKGpt.......................Ascp-LppsF..................................G.Tsc.p-Ihpp..............ILcKGE.lQlopcpRpt......................................	0	143	255	370
+4810	PF01142	TruD		tRNA pseudouridine synthase D (TruD)	Finn RD, Bateman A, Moxon SJ	anon	Prosite	Family	TruD is responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs [1].  The structure of TruD reveals an overall V-shaped molecule which contains an RNA-binding cleft [2].	19.20	19.20	19.80	19.20	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.33	0.70	-5.79	69	2142	2009-01-15 18:05:59	2003-04-07 12:59:11	13	12	1702	7	755	1714	284	327.60	28	79.21	CHANGED	M....................sth.h..htstPtssupl+sp......P-DFhVcEhh..s.hpssG.cG-H.lhlplcKpuhsTttlscplA+hhslst+cluaAGhKDR+AlTpQahSl...hsspp......s.ch.........t......slpllphs.RHs+KL+hGsLtGN+FpIhl...R.sls......st...lppplptlttt.GVPNYFG.QRFGps.usNhhhupthhpu................thp.......tc+....................................................ph+uhalSAhpSaLFNpllSpRlc......ttshspslsGDhhhhts.........stshhhspt....tthpt+ltptclp.ouPLhGp.sthhs.pupst.phEpplLsptsh...hhp...thtphth...cstRRslhlhs.pshp......h...sp.....slplpFtLPsGuYATslLREl	...................................................................................................................................h..................t....t.shhpt..........spDF.V.E...............................h...............t...................s............u....p..........G.....-..a..lhlplhKpshsTh..sh....phLu+....hh....t.l.....p.....+.......p.lu..aAGhKD++AlTpQahshp...hsttp............hssh................................................c....shplh.phs..h+pcKL+lGsLpGNt...Fplh.L.............R..pl.......s............................ts................................lc....pt....L........p...........pl................p.......p................t....G...h.sNYFG.QRFG..t......t...........s..s..........s.........h.......p...........huh..phhps......................................ph.................hppc..........................................................................................................................................................................s..h..Rphals..AhpS...hlFNphlupRlc.................phshp.ps....ltGDhl.hts...................................................ptph.ah.s.....p.t.........tt...ppchtt....t.c...l.................hs...us.L....Gt...s.hh.......s....ptt...sh..th-pthl...stp...s..........ht..........hhh.p....p.h.........p...usR...Rhhhhhs..p.plp.ap..h.....pt...............................................slplpFhLstGuaATsllREl.................................................................................................................................	0	257	430	625
+4811	PF01139	RtcB	UPF0027;	tRNA-splicing ligase RtcB	Finn RD, Bateman A, Eberhardt R	anon	Prosite	Family	This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyse the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage [1-3].	20.00	20.00	20.00	20.20	17.80	19.90	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.67	0.70	-5.48	136	2812	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	1686	6	719	2149	307	317.50	32	93.53	CHANGED	hpssshlas..ptthl-..................stulcQltslA.sL.....Psl..hc..shsMPDsHhGhG.hsIGuVhuhc.....uhlsPuuVGhDIsCGhphlpT.sLphp-l.....p.s...ph...pcLhstlhcslPsG...........hs......ttst...h..pthpphhtpthphsh.cpth.tht.................................s.ptlsppstp+ut...........t........QLGTLGuGNHFlElp.........h......th.t......h.slpc........sp....lhlhlHoGSRGlGppluscalchhpp....th....tcht...h..pls...........................................................Dc.pLAhhshsoptupcYlpAMshAtsaAhsNRphltchltc........................sh...pphh.........hthphl............h-lsHNhs...........chE..............pH....................tpplhVHRKGATRAh................hGp.llIPGSMGssSYlltGpttutt.......oasSssHGAGRhhSRspA++...................phshccltcphtt.......lpspspps................lh-EuPtAYKcl-pVlpsh..sslschVs+L+PlsslKG	........................................................hhs............l-...................t.uhpQl....hssA....ph........Phh..hp.....hhsMPDh.H....G...h...G....hsIGushshp.................shl.P..uhVGhDIsC..Ghthhps.sl.ttch.......t........p.h.tp.hhptl....ph...hs.u........................................................................................................................................h.pp.h..........................tplGolGsGNHFhElp.................................................lp..t...sp................lhlhlHoGSRGlGptlsp....ahthht.................................................................................................................................................................thshh.....to.....h...pp...Yhtthth...A.taA.hNRphhht.hhp..........................th..tt..............h.....................hsstHNhs.............phc...........................h......................pphhlpRKGAs..u.................................Gt.hl.IPGoMGshSalltGh.ss..................h..hSssHGAGRhhuRsp.s+p.....................h.sh.pp...pt.htt.......l.spp.t.................hh-Eh..........P.AYKs..lctVhts.......tslhphhhpl+.lhshK.....................................................................	0	285	480	624
+4812	PF01205	UPF0029		Uncharacterized protein family UPF0029	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.70	21.10	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.35	0.72	-4.37	179	4099	2012-10-03 01:04:38	2003-04-07 12:59:11	14	14	3898	2	953	2747	154	107.50	44	49.97	CHANGED	lK+S+Fluhht.lssp.p......-spphlpplcppa.c....AsH.psaAahl.....s.tssp....................................h.chsDDGEPuGTAGpPhL.plLpt....p.......sltslslVVsRYFGGl+LGsGGLlRAYssusppulp	..................................................................lKKSRFIshl.t...lps..-.........-A+sa..lppl+..p..c..+hc.........AsH.sChAahl.....G.t.p.s..p...................................................................................................h.choDDGEPuG.T.AGhPhL.shLpt....p............slssls.....lVVs...R.....YFGGI..+LGsGGLlRAYususspul.t.....................	0	306	605	816
+4813	PF01256	Carb_kinase	UPF0031; carb_kinase;	Carbohydrate kinase	Finn RD, Bateman A, Yeats C	anon	Prosite	Family	This family is related to Pfam:PF02110 and Pfam:PF00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.45	0.70	-5.09	9	4484	2012-10-03 06:25:16	2003-04-07 12:59:11	12	18	4216	36	1246	6104	1631	239.10	30	56.40	CHANGED	shlluGspsasGAslhuuhuAhphG..sGllpVts..sshsslpshhPclhscsh............st.h....thhpphcslllGPGLGps.th......hlphlLspppP...lllDADuLthls.p........sthpssslLTPHssEFtRLsssss..........tss+.phspphupphsssllLKGstsllss...suslhhspsGsushApGGpGDVLuGhIuuhLupst.........sshcAshsusahHutAuphhspctuh..shhsspltchlsp	............................................................................................................................................h.hllGG.....s.....t....s....hsGAs......h......h.....u....u......t....A..A....l......+....u....G..................AG.L...V..................p....l..h.s.......t.......p.....s.....h....s....s....l....t..s...t.....h..P..E...h..M.s.tshp.............................................t.h........t........h....p..p.......s....s..s....l.l....l...G....P....G....L....G....p.....s....p.h...s.tp................................hl.p...t...l.....h......p.....p....t....p...P.....................lllD.............A.....DAL..s..ll.upp.......................................thpp.p..h.....l.....lT...P.....HssEhs.R.L.h.u.h.sh.t........................................hpp..s...+...h.t....s...s....p....p..h...s..p......c...h.....s.....s...s......l...V.........L.........K.........G........s........s............T..........l...........l........s..s........................ss.....p.......h..h....l.......s....s....s....G........s.........s.........u...........h........A........o...G.........G.GD.V....L.uG.hIu..u....l...l.u.Q.th........................................ss...h-.A....u..t..s....u.s..h....lHu...hA..uch.hs.t.p...h.....hhsscl.t........................................................................................	0	429	805	1066
+4814	PF00902	TatC	UPF0032; 	Sec-independent protein translocase protein (TatC)	Bateman A, Moxon SJ	anon	Pfam-B_1212 (release 3.0)	Family	The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon [1].	25.10	25.10	25.20	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.57	0.70	-4.94	144	3911	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	3551	0	920	2811	2612	213.10	33	80.99	CHANGED	hpH.LpELRpRllhsllulllshh.l....sa.ha.........................spt...........lhp.hl.tpPhtthh........................................................................................................pllhhs..st-sFh.shl+luhhhulhluhPhllaQlWtFlsP.GL.....acpE++hhhhhlhhuslLFhhGshFuYallhPhshpFhhs....ass......................................th...h..........pshhslspYlshlhphhlsFGlsFpl.PllhhhLsp..hGllssphltctR.+asllhhhllAAllTP.PDshophhlulP	...................................................................h.pHLhELRpRLlhsllulllhhl.shh.hF.................................spp.........................lhp..hl..stPl.h.p.t.h.t.t.........................................................................................................................................................................................................................phlsos..lspsFh.s.lKlshhsulhluhPll.lYQlWsFluP..GL.....Ycp....E.+...+h....hh...shlh..so...slLFhhGhsFuYalVhPhshp.Fhhs........hus....................................................................................................................ps.s........pshhslssYlsFlhpl.hh.uF....GlsFE.l...Pl...llh.hLsh..hGllosppLp.ct.R...+asllshFllu.ullTP.PDlhSQhlLAlP..............................	0	296	615	790
+4815	PF01206	TusA	UPF0033; SirA;	Sulfurtransferase TusA	Finn RD, Bateman A, Eberhardt R	anon	Prosite	Family	This family includes the TusA sulfurtransferases [1].	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.07	0.72	-4.37	195	5303	2012-10-01 20:42:06	2003-04-07 12:59:11	12	41	2909	8	1162	3036	759	69.70	28	50.37	CHANGED	tplDspGhtCPhPllcs+cslcph.psG.....phl...p.....llsscssuh.pslspascppGt.pllph..pp...........ps..sta.phhl.cK	............pLDshGhtCPhPllts+cslp....ph.psG......-hL...p..................llsssssuh.psIst.asp.pp.Ga..pllsh.pp...........ss....ssa.phhlpK.....................................	0	395	744	997
+4816	PF02381	MraZ	UPF0040; 	MraZ protein	Bateman A	anon	Bairoch A	Family	This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva & A Murzin).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.18	0.72	-4.22	23	5872	2012-10-01 20:57:08	2003-04-07 12:59:11	13	3	3008	36	1347	3446	3377	70.70	25	92.00	CHANGED	hatGshphplDspGRlhlPupLRpthshp....h.slshGhsspLElastspWcphtpc..tchshsphspRthtch	........................hhtGshphp.l.Ds.p.GRlh...lP......sphRc...t....hs...hp..............t....l..h.l.......h.........G.........h.....p..s.......p.........l.t.lastspW.pp.htpc...tp.hs...p....t.....h...................................................	0	490	935	1179
+4817	PF03650	MPC	UPF0041;	Uncharacterised protein family (UPF0041)	Bateman A	anon	SWISS-PROT	Family	\N	20.50	20.50	20.60	22.40	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.65	0.71	-4.18	6	818	2012-10-03 12:15:12	2003-04-07 12:59:11	8	10	299	0	552	772	7	104.80	35	81.39	CHANGED	hhphth+thWpp.sGPKTVHFWAPshKWGLlhAGluDlKRss-hlSGsQshALluTuuIWTRauhllpP+NYLLuoVNFFltssuusQLsRIs..sYphpssD.hpp...hhhpth.....tucphup	.......................h.........hpt..sh.posHF......WuPl...hp.....WGlslA...ulsD.h...p.+...s.sEh.......ISss..............os................AL..sshu.h.lah..............R..au.hh....lpP+Na...hLhusphhstssthhQhhRhh.....pap...h....t...........................ttt.............................	0	173	292	451
+4818	PF03668	ATP_bind_2	UPF0042; ATP_bind2; 	P-loop ATPase protein family	Bateman A, Yeats C	anon	SWISS-PROT	Family	This family contains an ATP-binding site and could be an ATPase (personal obs:C Yeats).	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.89	0.70	-5.33	4	3506	2012-10-05 12:31:08	2003-04-07 12:59:11	10	6	3441	0	667	2112	733	275.40	43	93.34	CHANGED	hpllIloGhSGAGKoVAl+uLEDhGaYCVDNLPssLLPchs-hht...s+.oplAlshDlRshs.osclhctt.phhpc.thoP+llFL-AccsTLlRRYp-oRR.HPLuucsLsLEu.IstEpchLEPL+u+AsLIlDTSchSs+sLtEplccthtGsptcpholsVESFGFKYGIPlDADhVFDVRFLPNPHWsspLRPhTGh-tsVusal.++sEspcFl.ph+chLshhLPhhc+ps+SYlTIAIGCTGGKHRSVhIAEpLu-YF+uctpssh..pHRsLE+c	............................................pllIloGhSGuGKol.AlpsL........E...DhGaaCVD...N......L....P.ssL....LPc.h.s.c..h...ht.....................t.......s....p........p........c.l.AlslDlR.s..t..s..h.h....s.....p..l.h....ph....lt..p..h..t.s....p.......sh...s..hp.lLFLDAscpsLlpRY.p.-TRRhHPL...u...............s..........p..................s..................h...............h...........l....-........u..Ipt.E....RclLps.L.+stAs..hl.lDTopho......s..+cL+c...p.......lpp..t...h...t...s...p...p..p....p.....p...h....p....l..p....l.SFGF.K.a..G..lP.l.D......A.....D.....hVFDV.R.F.LPNPaa.s.cLR.P....h...TGlDp.sVtsYlhp.ps-sp.pFhpplpsh.Lchh...LPtap.c.-u......+S.............h.LTlAIGCTGGpHRSVhlAEpLuc.hL....p.......p.......c.......t.......p....s.....st......pHR-lt+......................................	1	224	442	572
+4819	PF01985	CRS1_YhbY	UPF0044;	CRS1 / YhbY (CRM) domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly.  GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants [4].  A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing [5].\	     In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity.  These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes [4].  YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome [1][2].	20.80	20.80	21.10	21.40	19.60	19.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.49	0.72	-3.98	144	3330	2009-09-11 02:11:35	2003-04-07 12:59:11	16	11	2788	4	855	1854	228	83.80	36	62.62	CHANGED	Lo.scp+chLRuhu+pL..cPl.l...tlG+sGlocullpplcpsLcs+ELlKl+lhp.s..stps....pcphsppls.........pp.ss.upllp....hlGcsllLYR	...............LosKQ+paL+uhAHsL...cPl..l.............lGcsGls-slltplcpAL-.p.+ELIKVclhp..s.....sc..-s........pppls-tls..........................................cp.os.uphVQ.....hI.G.+.h..lVLYR..............................	0	200	497	697
+4820	PF01894	UPF0047		Uncharacterised protein family UPF0047	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	20.20	20.20	28.00	21.30	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.34	0.71	-4.28	109	2428	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	2035	22	936	1913	1389	118.70	38	81.59	CHANGED	hcITspl...pphlppo..ulpsGlshlFs..HTTAulslNE.......shDPsVppDltphlscllP......pst..............tYpHsp......................ssusAHl+usLh.GsSlolPlpsGcLhLGTWQuIahsEaDs........s+.pRplhlplh	.........................h.lTccl..pph.s.p...h....s......s.lps.GL..lplhl..HToAuLslNE............NsDP.s.V+pDhpph....hp+l..l.Pcss...................................tY.cHsh.p.Gs................................DchsAHlK.uull.G.sSls.lPl..p.pG+LtLG..........TWQGIaLsEacs........sp.pR+.llspl....................................	0	352	620	800
+4821	PF01458	UPF0051		Uncharacterized protein family (UPF0051)	Bateman A	anon	Prodom_3219 (release 99.1)	Family	\N	20.80	20.80	21.30	20.80	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.03	0.70	-4.91	122	7024	2009-09-11 15:27:28	2003-04-07 12:59:11	12	12	3542	6	1556	4676	4761	229.60	32	51.85	CHANGED	s.sssstts+hllhltcsupss..ll-p.................s.ssssshpssssclh.lscsAplpahp.lpp.......spssh.phsstts..phtp.suphp.thh.shGuphs+tphpspL.tGpsupsplpulhh.spsppphDhpstlpHtu.p.spop.hh+ullpc.....pu..cslFpGhlplppsA.pposup.pscsLlL.ocpAcssohPpLEIhsDDV.csuHuAol.GplDc-pLFYLpoRGlscpcApplllpu.F	..........................................................................s.thstapRsllls--supls..alEs..................ssshtsss.sh..puulV...El.h.ltc.sApl+...ass.lpsh..........upssh....sh....ss.+R.u.....hs.t.c.suphp..Wsps..ph.G.u.tl..o..h..ph..ssshL..pG-supuchholuh.ss.s...p...Q...p.....t.Ds.ss+hhHhu.p.Tp.SpIlpKul.sps................p.u.ps.sapGhlpltpsA.ptu.c..........up.pscsLll..s..cpupu.-ThPhl-I.......c.ss...sl.ph.pHtAol.u+ls--QLFYLhSRGlscc-ApphlVpGF......................................	0	534	1049	1341
+4822	PF01933	UPF0052		Uncharacterised protein family UPF0052	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	\N	21.00	21.00	23.00	22.80	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.02	0.70	-5.10	32	3153	2009-09-11 09:44:17	2003-04-07 12:59:11	13	5	2883	21	736	1931	763	296.60	33	87.30	CHANGED	lVslGGGTGLuplLpGL+ph.................ssclTAIVTVuDDGGSoGcLRcths.hlsPGDlRsslhsL.u-.....pphhtplhpaRFp.....................................................ssstLpGHshGNLhLsuhpphtsshtcAlphhuplLtlcG..+llPh..opcslsLtAchp.....sG.........phlhGEspIsp...................................................ttthlcclhlp.........sppspss.cul-AIp-ADhIllGPGShaTSllP.LllssIscAlpcop.A.hlhlsNlhsp.G.Es......sthsssc+lcshtptsucthhDhlllsspt.sstp.tpphhpcssp.sphsttthcphshphhtsphlttt	...............................................................................................lVslGGGpGLu.hlLpuL+ph........................................ssclTAIVTluDsGGSoGclRcph.s.hl....sP...GDl.RNsLs...uL.......o-....................sphhpp..l.FpY.RFs..............................................................................ssupLuGHslGN......L.hls.u.l.........s.p.h..p.s.s...........h.h.....pA....l....p.hlsplLplcG.....+llPh.....o.p.p.slsLp..Ahhp................sG..................phlh...GE..s..pIsp............................................................................................................................................hps..hlcclhlp.......................................spstAspcs.l.....cA.....IpcA....D..h...IllGPG.ShaTSllPsLll.....sp.lucAl....t.......c........o........p...A.............hlYl.sNlhsp..G.ET.............ssho.stc+l....cslppa.....l....u.....p........hl...D....s....V..l...l..ss..p.......s.....p.t...h.t.p.t.hh...p.c..h...h..s...p.h.sh.t...t....pp..hpsh.......ht..............................................................................................	0	227	481	642
+4823	PF02130	UPF0054		Uncharacterized protein family UPF0054	Mian N, Bateman A	anon	IPR002036	Family	\N	25.00	25.00	27.50	26.30	23.70	24.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.90	0.71	-4.91	159	4595	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	4493	7	1042	2973	2301	142.80	31	85.81	CHANGED	l..phppptths..................th..lpthhphhttpht.................lslhhsscpplppLNppaRs+DtsTDVLSF.shppsst....................................................LGDIlluh-tstcpAtc.hs.+s..hpcclsaLhlHGhLHLl..G..YDHp.p.p...p-tptMcthEpplLppls	.......................................h.tp............................hpphlphsht.p.thttt.............ElolthVDspchppLNtpYR.scD...........pPTDVLSF..shcp.tth.t.h.........................................................................LGDll..Ishphspc..p.........ApEhG..+o................hccchuaLs............lHGhLHLLG....YDHh..p..s......-EtccM.uhppcILpth.t....................	0	363	685	878
+4824	PF01679	Pmp3	UPF0057;	Proteolipid membrane potential modulator	Bateman A	anon	Pfam-B_2192 (release 4.1)	Family	Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.53	0.72	-4.26	117	1655	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	1131	0	687	1065	84	50.50	45	65.92	CHANGED	tcl..l.hlllAIl....LPPluVal..ctG.hutch..hINllLTlLG.a....lP........GllHAlallhp	.............................t..hhcllluIl....LPPLGVhl....tpG..h...GhsF.....lINILL..TL..LG.Y...................lP..............GlIHAhalh....................	1	179	378	588
+4825	PF01893	UPF0058		Uncharacterised protein family UPF0058	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein has no known function.	25.00	25.00	40.60	40.50	24.10	19.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.00	0.72	-3.93	23	129	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	72	2	82	129	5	85.20	36	91.95	CHANGED	MH....K-ELlpLHphhspl++ahc.......ppsssptFcpY-pLcIsPsHlH+oKsEHKaAIFlLusslAphhu.pc-ts.spplup+h+-hA-csh+	......M+K-ELlcLHphLsplpchhcp......ppssst.hcpYcpLslpPsaIHKoKsEHKtAlFlLussluphhu.pc.cts.stphstthtp.s.p...t..................	0	13	54	73
+4826	PF02694	UPF0060		Uncharacterised BCR, YnfA/UPF0060 family	Mian N, Bateman A	anon	COG1742	Family	\N	22.30	22.30	22.50	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.62	0.72	-4.03	4	1396	2012-10-02 19:55:49	2003-04-07 12:59:11	10	3	1342	0	296	828	194	106.10	50	96.41	CHANGED	hl+olLLFlhAuLsEIGGuaLVWLWlREs+uhhhulsuuIhLsVYGalsTLQP.AsFGRVYAAYGGVFlshulhWGhhVDshpsDhaDWlGAhIsLsGVhVIhaAs.Ru	....................................hl+ohhLFhlsALsEIhG.C.aLsW.L.WL+c.s..tShahllPuuloLuLFsaLLT.LpP..uu...u.........GRVYAAYGGVYlssuL.hWLhlVDG..h+.shaDhhGAlIsLsGhhlIlhu..R.............................	1	88	179	236
+4827	PF02696	UPF0061		Uncharacterized ACR, YdiU/UPF0061 family	Mian N, Bateman A	anon	COG0397	Family	\N	19.90	19.90	20.10	19.90	19.60	19.80	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.86	0.70	-6.20	3	2147	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	1912	0	684	1870	2381	431.40	40	89.41	CHANGED	soLSslTcths.lspsYsAhDPVsLshF.ssRLla+Ns+LAssLu.....hcPSpLpcNuhsEh..V.st..EuLLsG.......shsPLApVYSGaQFGsaAuQLGDGRGlLLG-.hLsDGsohDWp...LKGAGhTPYSRhGDGRAVLRSoIREsLASEALHpLGIPTTRALSLVpossShspR-ssEP..uAVlhRFAPSHIRFGsFE+F+YRH-oEpltQLuDasIccYau......................Esph..pluDDE........D......KYctFFRcVVuRsAsLVAQWQAsGFAHGVLNTDNMSIhGLTlDYGPFGFLDcYEPuFIsNHsDauGRYSFuNQPAVshWNLQRLApoLSsllus-A..........LN...EALEc................YcpVaLT+YuplMuQRLGls.sLtcpMo.......Ep.....KEhs-sLVspLLslLApo+sDYscFFtpLp......Focs+SDsAsLhht.DE.....Flsu......A-a--WFAth.....hpG.......+LQ......QDhLppVPPoEhAARsoLhcpANPLhVLRsWllEcVl-...Aup+DG........DhosL++LaptLpNPa	...........................................................................................................................................sspll.h.hs.p...t.lA.t.tLu............s.t..h......p..t.t.h.h...........huG......ppl.h....sG.....................................h.p.PlAp...sY.u.G......H..Q......FG.s.......a..ss.....pLG.DGRulL..L..G..E......h.........t....s.....s............G.....p.........p....hD.hp...................LKG....uGhTPY............S.R..h......G....D.....GRAVLRSslREaLsSE..................AMa.t.L.GIPTTR..ALul....lso.s.....p.......sV..h......R..............E........p..........h..........-...s..............GAllhRlAsS.HlRhGpFE....a...a..............h..............h.....p...............t...........p.....................-.......p..............l......+.p........LAD..a....s...I.c.+...aa.P.............................................................................................th.t.ssp...........................p..............tY.hth....hppV...sp....RsApLlApWQsVGFsHGVMNTDNMS.IhG.TlDYGPauFhD.........s.......a-PsalsNp...sD....p.p.G.RYuasNQPsluhWNLt....+LApsL..h..P..l..l...s.......-..t...............................lp.......p.u...L..s.p...................................................................ap.ph.......h.....s...pa....t....p.t....M....c...pKL...Gl................hs...........................p-...Dp...t...Ll..spLh.plM..tp.....pp.s..DYTp.hF...RtLu....................................t..p.t....t....s...s...s..s..l...h............t.t.....................hh.s.p....................................................sta..c.t.Whtta.........tt..........................Rlt.........................pc...................t.s....t.....p.................p.tph..Mp......ps.NPthl.RNalsppAIc...tApp.G...........Dh..s.lccLhpsLppPa..................................................................................................	0	200	396	551
+4828	PF03401	TctC	UPF0065; Bug;	Tripartite tricarboxylate transporter family receptor	Mifsud W	anon	Pfam-B_3343 (release 6.6)	Family	These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria [1].  This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [3]. The TctABC system has been characterised in S. typhimurium [2], and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria [2].	21.20	21.20	21.20	21.50	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.38	0.70	-5.47	9	6762	2012-10-03 15:33:52	2003-04-07 12:59:11	9	22	1130	7	2903	6666	2997	269.60	28	83.24	CHANGED	lARhluppMucpLGQPVlV-N+sGAGG.IuushVApuAsDGYTlhl.susuh.slssahYsplsYcsh+DhsPVs.lsssPhVLVVsusSshpslp-LlshA+ssPsKLoaASsGhGoosHLsuElhpucsGsphhHVPYKGuuPAlpDLluG+VDh.MhsslsostshIpus+lRALAVsotpRpstLP-VPTlAEsG.ltGh-shsWaGhhAPpGTPssVlp+LssAhppAhpsPtlhcthpshGhpsh...ssoPpphsphhpuEspRWutLIpchGl	............................................................................ARhlupt.h..s..p..t..L....G...p..s..l.l.V..-N......+.s.G.A.u.G..slG.s..s.t.l.u..c.u.s..s...D..G.Y.Tl.hh....s.s..s.uh....sl....ss...t...l...h...t...p...l...s...a..c......s...hc.D.h..s.P.l.u.h...l.u...p.s.s.h.l.l...l..V.s......s....s....s....P....h....c....o.lp-l...ls..h..u..K.s...p...P...u..p...l.s.a..u...o..u.G...s...G.o.s.s....H....L..s....s.t...h....h....t.p......t.s...G....l......c......h....p....a.......V...P...Y...+....G...u..u...s.A..ls.sll...u...G..plsh.....hh........s...s........h.s.s.....s....h....s.....h.....l.......c......u.G..+..l+.s.L...A......V..s.......u...s.....p.........R.........h.........s.........t...........l.........P.........-.....V..PT........h........s.E.t...............G.....h.......s.........h...p....h.....s.....s.......W....h...........G........l........h.....u...........P..........s.us...P...s...sllpcLssslp.p..sl.p.s..s.p.h..p.......p..p.h.p.p.h..G..h...p...s.h......st.s...s..p.ph..s.p...h...lpp-...htca.tpllct.t.h...........................................................................	0	403	1505	2405
+4829	PF01980	UPF0066		Uncharacterised protein family UPF0066	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	\N	21.40	21.40	21.40	22.60	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.58	0.71	-4.15	184	2012	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	1761	6	580	1490	102	122.50	43	54.57	CHANGED	p+hssP+Q.sth..............sspuplclhspa....tpuLpGLEpaSHlhllahhHcs..................................hhp.P+h.t.......ss.tphGVFATRSPtRP...NPIGlSlVcLh..plcssp.....LtlpGlDh....................lDGTPllDIKP.Yls...hh.Ds	...............................................KhuhPRQ...sslsp......sspuplcLh.s.a..........ts-ulcGLEs..F..SHlWllFhFHps.............................................................................p...shcsp.V.R..P.PRL..s........Gst+hGVFATRSsaRP...NPIGhSlVcLc..plc..spp....................Lplu.ulDL....................lDGTPllDIKPYlPas..p...........................................	0	215	365	478
+4830	PF03006	HlyIII	UPF0073; 	Haemolysin-III related	Bateman A	anon	Pfam-B_1581 (release 6.4)	Family	Members of this family are integral membrane proteins.  This family includes a protein with hemolytic activity from Bacillus cereus [1]. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism [2]. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins [3]. The mammalian members include progesterone binding proteins [4]. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.	26.20	26.20	26.50	26.50	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.93	0.70	-4.94	81	4985	2009-01-15 18:05:59	2003-04-07 12:59:11	15	18	3463	0	1622	3448	460	203.00	27	78.87	CHANGED	ashppEhsNshTHhlGslhshhsh....hhlhshuthtt....s.ht...........................................................................hlshslashuhhhhhhsSslaHt...hsptc..................scthhppl.D+suIalhIAGo....YsPhhhhsh.....................................p.s.hs.hhhhsh....lWs.hulhGllhphhhh.........................tph..+hlpshhY....lshGahslhslhth..hhthsshs........lhhlhhGGlhYslGul.FYuh+.........................................................h...a.....tHtIaH..lFVlhuuhsHa	................................................................................................................................................htpEhsNshoHh........l.G.hlhs.l..h..sh....s.h..l.....h.h.h.u.s..tt............shht.....................................................................................................................................................................................hhu.h.slas...huhhhha.h.sSolYHs.h......h...st...p..................s+th.hp.th.DHsuI..alhIA....Go.......YTPh..hlhs.h.............................................p...s.........h.u.....h........hl..h...h.l.........................lW.s...h.u.lh.Gllh..c.h.hhh................................pph....+hl.sh......s..h..Y....lsM...GW.hs.l...hslhth......hht.....hss.hs.......................hhhlhh.G.GlhY...ol...Gsl...FYst.+...........................................................................................................................................h.......a...............tHtIaHlFVlsuuhhHa................................................................	0	475	832	1230
+4831	PF02082	Rrf2	UPF0074; 	Transcriptional regulator	Mian N, Bateman A, Yeats C	anon	IPR000944	Family	This family is related to Pfam:PF001022 and other transcription regulation families (personal obs: Yeats C).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.41	0.72	-3.86	118	8068	2012-10-04 14:01:12	2003-04-07 12:59:11	15	22	3692	17	1984	8534	1782	81.20	29	53.34	CHANGED	Mp.lospscYul+sLlhL...At.ptspt....lsspplAp..pt.sls.saLp+lltpLpcsGllcShRGstGGapLA+sspcIolt-llcul	.......................................Mp.loscscYul+.sl.lhl................Ah.....p..s...p....t..t................loh.p.plAc..p..sl.s..saLcplhspL..p+..s.G..l..l..p..o...h......R...G.s.t....G.G.a..p.L....u.+.s.s.pc.Iols-llcs................................	0	686	1302	1664
+4832	PF03702	UPF0075		Uncharacterised protein family (UPF0075)	Bateman A	anon	SWISS-PROT	Family	The proteins is this family are about 370 amino acids long and have no known function.	20.40	20.40	20.40	20.40	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.13	0.70	-5.56	9	2041	2012-10-02 23:34:14	2003-04-07 12:59:11	9	6	1964	6	505	1648	2620	357.50	42	96.82	CHANGED	.hYIGlMSGTSlDGlDhsLlchst...scspLltuchh.PhPssLRpplhsLpps.sssoLpphGpL-pplGhLaucslsphLpppplpsspIpAIGsHGQTlhHpPs.uphPFThQlGDssllApcTGIssVuDFRR+DlAhGGQGAPLVPAFHpAlFtssspspsVLNIGGIuNlSlLhPstsVhGaDTGPGNsLhDAWhp+aps..tsaD+sGtaAupGpVstsLLspLLs-PaFuhPuPKSTGREhFNLsWLpcpLtpt..............spDVQATLsELTApoIs-ultpttss.spcLlVCGGGA+NslLMtRLuthLPs.hpVsoTsphGlssDhhEAhAFAWLAapplssLPGNlPuVTGApphshLGAIaPs	..........................t.hhIGlMSGTSLDG.lDssLsphct....................pp..l...t..h....l....u....s..h..s..........h.....Ph.s.......ss...........L.+.......ptl......h......s.....l......p.p......s.......p..................p......t......s...l........p......p......h...u..pL...-........pp............L.u.p.haApAVp.tLLp.....p...ps..l...p.s.pcI.sAI.GsHGQTVhH..p...P...................p......s............................h..........s...............a..........Tl.QIGD.sshlAtp....T...GIsVVuDFRp.+DlAh..........GGQ.GAPLVPAFHpuL....h.......s.......c............s....s......c.......p......R.......h...l......LNIGG..IANlol........L.............................s....................s.......p.......s...............l.........h.......G..a.....DT.GP.GNhLhDu...Wh..t..+.p.t..u......................psYDcsGpa.A.tpG..p..V......sL..L.p.p.....h......L..s.....-..P.YFstssPK.STGRE.hF....s....hs....W...Lp..p..p..Lp..phst....s...................spD.....l.tATLsc...l.......T....A....hoI.......u....cp....l....t.............t.........h............s.....s............s.......c..................clhV..CGGGu+NshLMtcLtsh.L.........s..................s.......hp.....V.p...oo.-.s....h..G.....l.s...u.....Dth.E.............AhAF.AWLAh.csl.t.Gl..PuNlPuV.....TGAsp..slLGsla..h..............................	0	141	308	416
+4833	PF02367	UPF0079		Uncharacterised P-loop hydrolase UPF0079	Bateman A	anon	PSI-BLAST P31805	Family	This uncharacterised family contains a P-loop.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.79	0.71	-4.49	14	4392	2012-10-05 12:31:08	2003-04-07 12:59:11	12	12	4337	6	946	3129	2397	122.70	35	71.63	CHANGED	ThplGpplup.L.....psGsVllLpGDLGAGKTshs+Glupul.Glpt..tlsSPTFsLlp.Yp....sshhlhHhDlYRLtsh-.hphh.....t.h-h.hs.-ullslEWuEthsp..Lspppl..plplchhspucpph	.................................h.tlupplu...ph.h........p.su...s...l...lhLpGDLGAGKTTho+.Glsc....u.L....Ghpt........sV.p.SPT...a...o....ll.c...p....Yp......................sp.h..s.l..a..Hh..DlYRLs.cs.c.E.h.tth............................Ghc-a.h....hs.suls.llEWs.p.t.h.ts....hL...P...s....s.p...l...plplphtspsp...hh................................................................................	1	332	637	811
+4835	PF03652	UPF0081		Uncharacterised protein family (UPF0081)	Bateman A	anon	SWISS-PROT	Family	\N	29.20	29.20	29.20	29.60	29.10	28.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.52	0.71	-4.05	174	4409	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	4296	8	962	2703	2115	133.70	34	91.91	CHANGED	tplLulDhGp+RIGlAlu-shthh.Apslpslp.pp.............tshppltpllpch......p..ss.tlVlGlP.........hsh.s.Gststtspts.ccFuppLppph.........sl...s.lhhhDERhoohtAp.phl..h.t.......tsh.pp.....pc++p...hlDphAAslILpsaL-p	.............................plLulDhGoKplGVAluD..hs.hh.Aps.Lpslp...sppt.............p..shspl.tcllcca.......p..ss....tlVVGLP.......................hsM....s.Go.p.us.t.sp.ps.cpFup.pLpp.ph.............sl.....s.VthhDERLoTstAc..ptL...h...p..........................tsh..p+............pc++p.....hlDphAAsl..ILpsaL-....................................................	0	324	638	820
+4836	PF01868	UPF0086	DUF49;	Domain of unknown function UPF0086	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease P protein subunit p29 proteins.	21.00	21.00	21.00	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.76	0.72	-4.34	36	446	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	413	9	311	441	62	88.50	28	44.89	CHANGED	hlsspNllp....HELlGLclcVlpopssshlGlcGhVlcET+solhltTpcs...tplPKctslFpFplsstp............................VclcGshLhuR.PEcRlc++	..............h....tpLhp....t-hpGshlpVscSps...suhlGlpGIVlpETcpshhl........l......s.cc...s.....p......h..............+.h..........lPKpsslFp..hplss.t..............................................................................................hplhGpph.hRstcRht+.............................	0	99	173	254
+4837	PF03007	WES_acyltransf	UPF0089;	Wax ester synthase-like Acyl-CoA acyltransferase domain	Bateman A, Auchincloss A	anon	Pfam-B_1896 (release 6.4)	Domain	This domain is found in wax ester synthase genes such as Swiss:Q8GGG1. In these proteins this domain catalyses the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters [1].	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.70	0.70	-4.83	16	1646	2012-10-02 12:01:53	2003-04-07 12:59:11	11	16	348	0	475	1277	107	248.90	24	54.16	CHANGED	LushDuhFLhhEsssp.hHlGtlslhchs.tsss........hcchtsshtpptphhPhh+p+.hsh.hshststWhsDschDlsaHVRRsALPuPGshcELh-LlucLtupsLDRsRPLWEsallEG.LssGRhAlhhKhHHAlsDGVuuhplhtphhstsPcssshsss.p.ssss....psphpttu....................hshsptltthssulsGsspssschhttsh.........spssshshsss......poshN.sslutpR....RhustplsLscl+tVscthGsTlNDVs	.......................................................................................hsshDthalhhE..s..sp..t.....h.H.sutl.hhhp.s......sss.......................hcp.h.h.pt.h.t.p.....p...h.t.hh..P.h.h.c....p.+....h...........h..s.h...s.t.....s.hW..h.p..-s...p.hD..lshHl....R.....+....s....u.L....P......s....P.....G...s......h....c...........-.....L.....h..c.hl.....uc..l.t..up..L.D.+..s.R..PLWEh.....a.l......l....E........G......L...........s......s............s..............R......h......A............l..h.hKhHHulsDGlu.u.hp.lh...tph.h....s.....t.s...s......s..s..s...h..s..s.......h...t...ssts.........tttht..s..................................................................ht...h.hp.t..l..t....t....h......s..s..s..l...t.......s....h....s......p...s.s..h.p.hhttsh................st...p...h..s..h...s....h...s...s.s......................to..h....N....s..s.l...s...s...tR......................+.h..u.s...t.p.hsLscl+tlt.p...t..h.......s...solNDVh............................................................................................................................................................	0	129	319	422
+4838	PF03653	UPF0093		Uncharacterised protein family (UPF0093)	Bateman A	anon	SWISS-PROT	Family	\N	24.50	24.50	24.60	25.00	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.15	0.71	-4.25	64	1256	2012-10-01 21:57:53	2003-04-07 12:59:11	8	1	1156	0	386	1034	1528	142.40	37	93.54	CHANGED	h..shY.WlKuhHlluVluWMAGLFYLPRLaVYHs-st.sts.ptpphFp....hMEc+Lh+hIhsPAMlsohlhG.lh.lshts....uhh.hs..sWh+s.KlshVllhshaHhhhsthtKchttspsphos+haRhhNElPTlLhllIVlhVllKP....F	...........h...hahWl...KuhHllulluWh..AGLFYLPRL..FVYHupsp.ss...s...........t....p.pphp.....lME++La+.hIhs.PuhlsollhG.hh...Lh.ht.........thhh..h.st..GWhHs..K.....LshVlLLlsa.Hh.h..s..u..t...hh...+phtp.sp....s.p..+.S.t.+.aa..Rh.hN..ElPsll...h...l.s.IVlLVllKPF.....................................................	0	107	248	316
+4839	PF02016	Peptidase_S66	UPF0094; Peptidase_U61; 	LD-carboxypeptidase	Bateman A, Studholme DJ	anon	SwissProt	Family	Muramoyl-tetrapeptide carboxypeptidase hydrolyses a peptide bond between a di-basic amino acid and the C-terminal D-alanine in the tetrapeptide moiety in peptidoglycan. This cleaves the bond between an L- and a D-amino acid.\	      The function of this activity is in murein recycling. This family also includes the microcin c7 self-immunity protein Swiss:Q47511. This family corresponds to Merops family S66.	19.70	19.70	19.70	20.10	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.71	0.70	-5.46	167	2826	2009-09-11 05:12:09	2003-04-07 12:59:11	10	10	2139	40	547	2166	479	284.20	28	90.74	CHANGED	lulluPS....sshpp.p..ph..ppulphLc.shGhplhhuppshpp..ht.....hh...uussppRsp-LpphhpDsslc..uIhsspGGaGusRlLshlD...as.....hl...ppp........PK..hhlGaSDlTsLthslhtps.Ghso..hHGPh.....hss.ht........t..................sshohpphtph...Lhs.............................t.ths.sssththhtsG..........pspGpLlGGNLsll.............spLhGTsa.hs....................phcs.......tILalE-lsEt....sacl-RhLtpLphuGhhcplpGlllGchsth.........s.t.stslpcllpchh..tths.....lPllhshshGHst.sph.....slPlGspspl..s	...............................ltlluPS........sthpt...p...th...ptulppLp....shG......hplh...s..pthhcp............t...hh.....uu.os.ppRhpDLp........phh..p..s..s..s..l..c...hlhssh.G.GasusRLLsh.lD......ap.......tl.......pps.........PK.....lhhGaSDhTulptulhtps...slh.T..aaGPh..hssths..........t.................sshohppahph.....lps..................................................................thssth.th.hs.ss......................pspG.plhGGNLshL..............t.tlh.G.T.sa..hP............................phcs.......tILhLE.-.s.sEp........shcl-R...hLhpLtt....s.G.lhsphpulllGpaptt....................s.stsh..sh.pp.ll.tphh.....tphs..................lPllhshshGHsp.s.p.h.....slPlGspupl................................................	0	184	356	461
+4840	PF01981	PTH2	DUF119;UPF0099; Pep-tRNA_hydrol; 	Peptidyl-tRNA hydrolase PTH2	Enright A, Ouzounis C, Bateman A, Mistry J, Wood V	anon	Enright A	Family	Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation.	21.10	21.10	21.90	21.20	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.37	0.71	-4.39	69	1006	2012-10-02 19:40:38	2003-04-07 12:59:11	11	13	703	22	562	916	123	109.50	31	60.74	CHANGED	phKhllVVRsDL+MuKGKlAAQsuHAulushhph.........hpts...............................phlcpWh.ppGQtKlVL+sp..spccLhcltppAcphGlsstlIpDAG+TQls.PGohTlLulGPuspphlDclTGcLKLL	.............................................t.hlllR....s....D....L........p.....M....s........p.........GKlAAQ.su...HAulsshpth............ppp..s..t.........................................phlc.p.Wc...p..s...G..ptKlV..lcs.t........s.p..p....phh.......p...L...t.......t.p.Ap.p....h.....sl....s....st.....l.lpD........A................G..hT...p........l....s....s.......u.........o..h.....T..slul....tPsstp.lsph..stpL+Lh.....................................	1	194	334	470
+4841	PF02021	UPF0102		Uncharacterised protein family UPF0102	Bateman A	anon	SwissProt	Family	The function of this family is unknown.	21.20	21.20	21.20	21.30	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.07	0.72	-4.06	8	3091	2012-10-11 20:44:43	2003-04-07 12:59:11	12	8	3030	1	769	2274	378	92.40	35	72.54	CHANGED	tuEshAscaLcopGhpllsRNaRs.phGEIDlIApc..scplVFVEV+sRsussassh.htuVT.+KtcKlhcTAppaLApps..hpssssRhDVlsVh	.........................h.uEphA.tpaLp.p.p.Ghplls..pNa+......s......+..........h........G....EIDlIhcc.............sp.......s......l...V............FVEV+h...R...p.....s.....s..t.....aG.s...............s...t...tu.Vo..hpKpc+lhp.sAp.ha...L...t...p..ps......ht...s..s.....s.....s..RFDllul.t..............................................	0	263	523	664
+4842	PF01875	Memo	DUF52; UPF0103; 	Memo-like protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family contains members from all branches of life.  The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family [1]. It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [1].	19.90	19.90	19.90	20.00	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.79	0.70	-5.53	11	840	2012-10-01 19:17:44	2003-04-07 12:59:11	12	10	707	8	506	901	112	265.40	28	88.15	CHANGED	.PulAGsaYspssccLpphlc.hhhcshs.t.......tRtlhs.......PHAGYhYSG.sAupuYptLsp....s..-pllIlGPsHsshs.sslulhs.utacTPLGslcVDp-hscpLhpppth......hs.--hsc.htEHSlElQLPFLpahhtc.......hKIVPlhluhps.EsstplGchlscsl+-.s...slllsSSDhsHau.....................................Ppclspph...DchhIctItph....s.cshhphlpphssT.lCGhsPlhlhl.hh+phs......pcuclLcYusSu-lstspsSsVuYAuhl	..............................................................................................sshAGtaYsss.tp.Lpppl.p...th...h..t....p.s..h..t..tt...........................s+sl.ls................PHAGYhYSG.sAAhuY.tt............ls..........sthc.....plhlLGPuHps....hh...p......s....su.l..s.s.......h.......sta.pTP.L.....G.........s.........l.........tl.........D...pchh....p.pLhp..p....t.h...............................hph.....s....ptsc..pp.....E..HSlEhpLPalpphhpp...............h.pl.lPlh.......lG...........t...........h.s............p....h......t....t....p.h....u....phl..sph......h...t..c.p..........slhllSSDhs.H..a..t.....................................................................................st...th.t.pp.h.....D.p..hs...h...........p.....tltph................c.pthh......p..h..l.p..p.....h..t.o..hCG.htPlsshlth.h..pth.t........................hp..h...phlpYtpSu...p.s.p........s.....p.s.p...sVuYuuh.h............................................................................	0	198	336	436
+4843	PF03706	UPF0104		Uncharacterised protein family (UPF0104)	Bateman A	anon	SWISS-PROT	Family	This family of proteins are integral membrane proteins.  These proteins are uncharacterised but contain a conserved PG motif. Some members of this family are annotated as dolichol-P-glucose synthetase and contain a Pfam:PF00535 domain.	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.32	0.70	-5.14	128	4592	2009-09-13 19:27:26	2003-04-07 12:59:11	8	18	2804	0	1355	3742	1049	287.10	16	61.23	CHANGED	shhhlh......hlhtthshpplh.............................ptlt...phshhh........lhhu..hh....lshhs..........................................hhl..puh+...........Wphllpt........ht...............plshhps.h...thhhhuhh....hsh...l.hP..uphG............-sh+shhLp................ppulsh.....spuhss.h........lhpp..lhsh....hslhhhshhshhh.............hh..shhhhhhhh...............hhshhhsshhhhhhhlhth................................h.h.hhht+ltptht.phtpshpt........................h.t...h...hhhh.hhohhhahhthh.thahlhtuhu.hsh........shhhhhhhhshshlss....hlP......sPGG..hGshEsshshhhs.....hhGhssstu.....hsh........sllh+hlshhhsh......h...................hGh	.............................................................................................................................h....hh.....hhht...t...h...s.ht.plh.............................p.slp.........phs.hhh.............llhu.....hh....hshls......................................hhh.......sh.t..h.p.h.lhpt..............hth..........................clsht...ps....h....hsshhs.h..hst...h..hs...sh..s.G......tsh+hhhhp.....................pt.ulsh.....spsssh....h.........lhtt......hhsh......lslh.h..hs.hlhhhh.............................h..h...h.ht.hh.h...hh........................h..hs..h.s..l.hhh..l....h.hh...hhhhth...........................................................................................h.h..p.h...t..p..h......h..t....p..htt.t.htt..............................h.........hhhh.hhhohlpahsh.sh....hha.h.l..h....h.h.hs.hss..............shhth.h.s.h...h..h.l.u.tlsu.....hls....hhP.GG.lGs...hEsshlhhhs.........hhs.l.s..t.s..ts..........lss..................hLlaRlhhahlsh..hlu...............................................................	0	455	894	1153
+4844	PF03656	Pam16	UPF0108; 	Pam16	Bateman A, Wood V, Studholme DJ, Mistry J	anon	SWISS-PROT	Family	The Pam16 protein (Swiss:P42949) is the fifth essential subunit of the pre-sequence translocase-associated protein import motor (PAM) [1].  In Saccharomyces cerevisiae, Pam16 is required for preprotein translocation into the matrix, but not for protein insertion into the inner membrane [1].  Pam16 has a degenerate J domain.  J-domain proteins play important regulatory roles as co-chaperones, recruiting Hsp70 partners and accelerating the ATP-hydrolysis step of the chaperone cycle [2].  Pam16's J-like domain strongly interacts with Pam18's J domain, leading to a productive interaction of Pam18 with mtHsp70 at the mitochondria import channel [3].  Pam18 stimulates the ATPase activity of mtHsp70.	29.10	29.10	29.10	29.20	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.58	0.71	-4.34	3	354	2012-10-01 22:35:57	2003-04-07 12:59:11	8	8	266	8	259	368	4	119.10	36	83.90	CHANGED	MA+RsAlQVIlsGsQVVGKAFARAlRQEh.....AAuRsAAuAtssAS+.RusAsSNhu.GISL-ESpQILNVcc...sLNhEEVpK+YEHLFcVNDKSKGGSFYLQSKVaRAKERLDEEL.+IctKE-KcKupsA+T	..................................................MAthlh.plllhGupllGRAFscAh+Qth..........t..uu...p...t..s....s...t...u...t...t..p..u....st.....ts..s...s.t..s......s...h......p.....G..........hoL..cEAppILN.Vpc.........ths..hEc.lt...c..........+ac+LFcsN......-.....p...p..p.......G...GSFYLQSK........VhRAKERL-.......tEl....p.......t.t.p...............t.t.........................	0	84	143	214
+4845	PF03657	UPF0113		Uncharacterised protein family (UPF0113)	Bateman A	anon	SWISS-PROT	Family	\N	22.70	22.70	22.70	22.70	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-4.58	4	344	2012-10-02 17:37:24	2003-04-07 12:59:11	8	3	328	4	256	328	3	168.10	36	92.25	CHANGED	h+lRpssstEhcLIcctLptYG.ts..alpphth.shtGch+-VasVshslhcslc...Lp.apsGhplGs..hsEhth+hphsLtthhhllpsohN.hshls.+uEhLFLYGRDlatcultchsthGp...lhlhNc.s-hlGIG............hpDthhlKNL+DhG.YLR+	...................................................................R.hpt.E.p.hh...t.h.t...h...h.........h.........................................c....h.......p.p........c...RVYYVs-pl...h.+...h...As....s..........c...........pL..h...S......hGsClGK..Fo.K..........p..s...K..FRL..H..I..T..AL.s..h..LA.aA.+a.KlWlKPsuEhsFLYGNcVlKut...l..GRh...o....E.s...s.s.pat..GVVV..a..o..MsD...lP.LGFGhsu.....ttps.t.p.hp.s..s...s..h..l.l.h.p...............u.......DlGEYLR........................................	0	87	139	208
+4846	PF03350	UPF0114		Uncharacterized protein family, UPF0114	Mifsud W, Vella Briffa B, Bateman A	anon	Pfam-B_3587 (release 6.5) & Pfam-B_10597 (release 10.0)	Family	\N	21.50	21.50	23.40	23.00	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.59	0.71	-4.20	30	1494	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1367	0	351	823	291	119.80	42	68.01	CHANGED	llasoRalhl.hhlGlllutlshhlphhhplhchl..........sphtph............sc.spllLsllslIDlhLluslLlhlshGhYEhFlS+lshtpp...................-pPcWLshhshssLKhKLutsIlsI.ulphLcpah	....................................hauSRWLhsPlYhGL.luhlsLs..l+Fh.pElhHll.............sslh.sh.............................sE..s-l.l.Ls.lLuLl..DhsLlusLLlMVhhuGYEsFVSpL-.lscpp......................-c.pWLu+hssssLKsKlAtSIVuISSIHLL+sFh............................	0	68	180	274
+4847	PF01594	UPF0118	DUF20; 	Domain of unknown function DUF20	Bashton M, Bateman A	anon	Pfam-B_495 (release 4.1)	Family	This transmembrane region is found in putative permeases and  predicted transmembrane proteins it has no known function. It is not clear what source suggested that these proteins may be permeases and this information should be treated with caution.	27.20	27.20	27.20	27.20	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-11.86	0.70	-5.45	32	12059	2009-09-10 15:51:07	2003-04-07 12:59:11	11	19	4455	0	2730	8340	2223	323.20	19	87.74	CHANGED	hhhhhhhhlhhhshhhhhs....lhhshlluhlluhlhpslhphL.ppttht+hlulhllhlhhlshhshhhhhlhs.hhsphtpllpslP............phhsthtshltplttph.hh............t.ht.thsphlsphhspl.....hstlhshhtthsthhlphlhhllhhhahLhctcphhphlhphhPtph+pphpthhpphppt...ltsalhuphlhullhulhshluhhlhsl...aullhullsslhs.lIPhlGuhlshlP.hlhhhhhss...hthlhslhhhhllp.l.spllpPhlhuct........hslpPlhlllullhushlhGhlGhllusPlhsllpshlpthh	..................................................................................................................hh...hhhh.h.h.hh...h.hh...h.h...hht...............sllhsh....lluhhl....sh.....l....h........p.........P...........l................h...............p............h...............l........p................c................h................t................h..............s.................R............s..............l............u...........s..............h.......l...h.........h......l..l.h...l....h.l....l...s.....h....h..l....h....h...l....h.......s.......l.....h...p...p...h.....s....p.........l....h.p..p..ls.............................................p.h..h....p....p.....h...p....p.....h....l....p....p.....l.....t..t.h..t.h...........................................tth..t..t..t..h.....s....p...h.....h...p.....p...h...t..s..p..h....................................hs.t.h....h....s....h....h...s....s....l.......s.......s......h...h....h.......t....h.......l...l...h...h.......l.h....s....h.......a......h....l....h...-....t....p....p....h..........h....p....h....h....h....p......h....h.....s....p....p.........p....t....p....h....t....p....l....h....p....p.h...spt.......lssaltu.ph....lhul...l.....hGl...h....s....h..l.....u......h......h......l........h........G..l.........sa...ul..l..l.ul..l..s..slhs..hlP.h...l...G......s..hl....u.h.l.P...s....s....l..h..s....h....h........h.............s...............s.......................h.t........h.l....h......l....l....l....h....h.h.ll...p..t.l.pu.s.l....l.pPhlhucs............lslpslh.lllu.l.lhu...u.t.......l...h....G........h...h......G.hllulPlhulhtslhp...h..................................................................	0	829	1727	2265
+4848	PF03715	Noc2	UPF0120; 	Noc2p family	Bateman A	anon	SWISS-PROT	Family	At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus [2]. It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for  ribosome nucleus export [1]. This family was formerly known as UPF0120.	19.80	19.80	19.90	22.30	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.84	0.70	-5.56	38	404	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	292	0	273	396	6	277.60	32	42.37	CHANGED	psshl-slLKssYpual+ss+h.ssh+ohshINFh+NossELau.lD.shuYphuFtaIRQLAIHLRsulssps........c...............-ua+sVYNWQalauLchWucVLuth..........tspposLcsLlYPLVQlslGsh+L.lPospaFPLRhall+uLl+LS.psTusaIPlhPhLhElLsSs......phs+s.s........................+....pu.shcshDFphsl+sspuhLpo+sYp-ulh-plh-LlsEahshaupsIuFPELshPsllpL++ahKps.......+ss+as+plppLlcKlppsupaIpc+Rsp..lsFuPsspspVcsFhp-hc..hcpTPLspYhts.+	.............................................t..hhpslLKthY.shlps......s..+h...ss...spshs..hIsh.hppohsELau.l....D...shuYppuFhaIRQLAlHLRsuhstpp................K...........................................................-sapsVYNWQalpsLchWspVLut.............spps.LpsLlYPLsQ.....lhlGsh+L.lPo..s.paaPLRhphl+sLhpLu....p....so.ssaIPlhshll..E...lLpps.......php+t..s.......................................p..........ps.sh+slsFsshl+hsps..Lps+sap-.ulh-p...............lh-LlhEahsh..hup..sIuFPELshPsllp.......LKpalKps.....................+ssphs.......ptlppLlpKlppNupaIpp+R.pp..lsFuspctttVpta.pphp...ptTPLstaht........................................................	0	102	161	232
+4849	PF03661	UPF0121		Uncharacterised protein family (UPF0121)	Bateman A	anon	SWISS-PROT	Family	Uncharacterised integral membrane protein family.	20.60	20.60	20.70	21.80	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.58	0.70	-5.18	7	337	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	274	0	234	322	0	229.50	21	81.74	CHANGED	.ps..s..s.s....uuhhpalhsN+l-TAhWhuRlhTlahulhalLPhlssp.uhs....hYp+sLlAsAATSALRLHQRLP.pFp..hSRtFLtphhhEDSsHYLlaSllFl.shPlohsllPVhLFulLHusoaopKlLDshG............pNShhhsR....hlshlphppQNIL+hIACsEIhLMPhslhhhFSGpuullhPFlYY+FLshRYSSRRNPYsRshFsElRlslpslAhpspCPshlp+hlhsuIsFlSRLAPssh	.................................................................................................ht..........................................h.ah..phhslh.s.sh.h.ah.l..s..h.h....s.......p.....t..tt....hYphu......hl.uss.h.o......u....l...h...l...a..p.....p..h....thp.........h...s....t...t..h...l...t....p...h...l..t....-.-.sspY..L.....hh.uLh.a.l....h....s..h.....l.h..h......u.llPh.hlaSlhHsu.oas.....c.....p.hL.............sh..s.............................tp.s.t.h.tc......lhp...hVppttps....hht.h...s.AssEl........h.....l.h.h.h.h.l.h..h.lh..t......ptSh........l..h.l.Yhp.FL+hRY...pp....ssaspshatphphhl-t.hh.p...tsP.hhtp................h.................................................................................	0	77	126	188
+4850	PF04297	UPF0122		Putative helix-turn-helix protein, YlxM / p13 like	Kerrison ND, Finn RD	anon	COG2739	Family	Members of this family are predicted to contain a helix-turn-helix motif,  for example residues 37-55 in Mycoplasma mycoides p13 (Swiss:O05290). Genes encoding family members are often part of operons that encode  components of the SRP pathway, and this protein may regulate the expression of an operon related to the SRP pathway [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.21	0.72	-3.99	9	1476	2012-10-04 14:01:12	2003-04-07 12:59:11	9	2	1462	5	202	999	31	100.70	44	89.94	CHANGED	l-KTh+hshLF-hYtuLLTcKQtsYhpLYYh-DhSLuEIAEcaslSRQAVYDsIKRTpchLppYEpKLpLhpKaphRpclhpclp-ph.p.t...phhc.l	..........................EKs.RMN.hLF-FY.usL...L....T...c...KQ..ps..Yl.E.LYY.h-DaSLuEIAEpasVS....RQAVY....D....N....I.K..R..T.c.....c.l.L.E.-.YEpKLc....lhp....c....a......t.R....p....p....lh...c...pl....t...phhsp..p.........h................................................	0	92	147	176
+4851	PF03660	PHF5	UPF0123; 	PHF5-like protein	Bateman A, Wood V	anon	SWISS-PROT	Family	This family of proteins the superfamily of PHD-finger proteins. At least one example, from mouse,  may act as a chromatin-associated protein[1]. The S. pombe ini1 gene is essential, required for splicing [2]. It is localised in the nucleus, but not detected in the nucleolus and can be complemented by human ini1 [2].	26.70	26.70	27.30	30.50	23.80	26.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.82	0.72	-3.98	19	319	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	281	1	224	212	4	103.40	71	89.84	CHANGED	MSRHp.DLlhChKQPGtslGhLC-pCDGKCPlCD...SaV+P..pohVRICD-CSaG.......phss+CIlCG.......s.Gl.....s-AYYChECs+LEKDRDGCPRIlNlGSs+sDh...aap+K+ts	..............Mu+HHP.DLIhCRKQPGlAIGRLCEK.....CDGKCsICD....SYVRP.....sTLVRICDECNaG.......oYQGRCVICG.......GsGl.....SDAYYCpECTh.EKDRD..GCPKIlNLGSo+TDL...FYERKK.hu.........................	0	78	126	188
+4852	PF03658	Ub-RnfH	UPF0125;	RnfH family Ubiquitin	Bateman A, Burroughs AM, Iyer LM, Aravind L	anon	SWISS-PROT	Family	A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly co-occur in two distinct gene neighborhood  contexts. In one it is associated with a START domain protein, a  membrane protein SmpA and the transfer mRNA binding protein SmpB.  This association suggests a possible role in the SmpB-tmRNA-based  tagging and degadation system of bacteria, which is interesting given that other members of the ubiquitin system are analogously involved  in protein-tagging and degradation across eukaryotes and various  prokaryotes. The second context in which the RnfH genes are present  is in a  membrane associated complex involved in transporting  electrons for various reductive reactions such as nitrogen  fixation [1].	22.40	22.40	22.70	23.30	22.20	19.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.55	0.72	-4.11	10	1334	2012-10-03 10:59:06	2003-04-07 12:59:11	9	1	1297	2	253	739	157	83.20	51	83.26	CHANGED	IcVEVVYAhPc+QhLpclsVs-GsTVc-AIppSGlLphaP-IDLppsKlGIFu+slK..L-ssLKDGDRIEIYRPLlsDPKElRRc	......................................ltVEVsY.A.L.P.-..+Qh.L.hp.lsl.......p-GuTVc-AIcsSGl.L.p.h.......hs-........I........D...L.............s....p...s...K.V.G..IaSRssK.......Lsssl+DGDRVEIYRPLlADPKElRRp...........	0	53	131	196
+4853	PF03458	UPF0126		UPF0126 domain	Yeats C	anon	Yeats C	Domain	Domain always found as pair in bacterial membrane proteins of unknown function. This domain contains three transmembrane helices. The conserved glycines are suggestive of  an ion channel (C. Yeats unpublished obs.).	23.40	23.40	23.80	23.90	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.85	0.72	-4.36	177	6692	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	2470	0	1367	3826	471	80.50	31	75.05	CHANGED	lhhhDhlGlssFulsGshhAhp..th......s..h.hssllluhlTulGGGhlRD.lLhsp.h..Phhhh..p.phYs....hsulhuuhl.hhhhhthhh	.................hlLDhlGlssFulsGshhAh....ch...ph.........s.....h..hssllhuslTulG.GGhlRD.lL.hsc.h...Plhhh.........c...thYs.............s.s.s.hh.uull.hhhhh...hh..........................	0	358	812	1115
+4854	PF03673	UPF0128		Uncharacterised protein family (UPF0128)	Bateman A	anon	SWISS-PROT	Family	The members of this family are about 240 amino acids in length.  The proteins are as yet uncharacterised.	20.40	20.40	20.80	20.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.36	0.70	-5.07	5	20	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	0	16	22	0	215.40	49	96.05	CHANGED	MLlNTLVFETLGsPEKEREFKlKDLK+WGFDLlLGKlDGc-AYFsSchusREsGDKaocsGKEYEIcElLcELPKNs+LaA+IEhEcGpAYLhsaLREED.pNhPlL+pPAsplLhAFaKK+KLspLlKsl+uVGloT-FaKc+.GlcSlPLPYEELPPVARRFLR-ARKVEK-.sGFGRluFAYFGEs+-K-sRYRLpWLLPTIALFDl-IScKlDKsLuhLK	..l.shhlhEshGss.pERcFKhKsLKtWGaDLhhGpI-GccsYFsuchsc+ctG-p....YspcG+EYclpEsh.cElPKNs+LhA+I.hEcGpsYL..hhaLc-ED.psh.lh+.ssthlLhtFacKcKLspLlKtl+sVGloo-hhKcs.hhcuhPLPYEEhPPhsRRhLR-sRcVc+-.TGFGRhsFtYaGE.cDtptpYRlpWhLPTItLFDl-IApclDKsLuhLc....	0	6	6	9
+4857	PF03647	Tmemb_14	UPF0136; TMEM14; 	Transmembrane proteins 14C	Bateman A	anon	Pfam-B_2984 (release 7.0)	Family	This family of short membrane proteins are as yet uncharacterised.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.05	0.72	-3.59	61	574	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	290	3	347	543	6	92.90	30	64.14	CHANGED	phhuhshuuLlssGGlhGYs+sGShsSLhAGlshGslhuhu......uahlp.......spshuhtlul.ssSs.............sLssshshR....hhpop.KhhPsslhhslusshsshhhh	.................hhuhsausLlssGGlhGYh+sGShsSLhA.GlhhGslhhhu.............uahhp..........ppshshhl....uL.hsos................................sLssshuhR...........hhp.ot.K.hhPsGlhsshohhhhshh..h......................................	0	95	186	274
+4858	PF03677	UPF0137		Uncharacterised protein family (UPF0137)	Bateman A	anon	SWISS-PROT	Family	This family includes GP6-D a virulence plasmid encoded protein.	34.00	34.00	34.50	34.20	32.00	31.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.76	0.70	-4.84	6	77	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	47	0	11	42	3	230.60	45	92.16	CHANGED	MupLKp.h-shFKKNppsphEshpKKchpt-.......lhssoLSspEcp+lcpLl..p+YsFcDE.hpccDltulppLouQIKpIp+QpVLLhGE+IhKVR-LL+o..apEssFSuWl.Lsaus+posYNhLsYYELFhsLP-.sLKlEhpplPhpAsYhLASRcGo.E+K.clI+phpG.opophl-Ilc+.hP.l...........ss-p+pppLScphlplL....+llspsscLSp.spslLcpLhcKlp.......spsp	................................MuplKp.h-shFKKs.p...sphpshtK+phphE.......hhssp.LSSpEctphcpLl..EcYsaucE.h.ppDltp....lphLouQlKpIp+QtVLLhGE+IhKVR-lL+s..ap-ssFSuWl.Lsaus+posYNhLsYYELF.sLPc.oL+hEhpplPhpAsYhLASRcGs.ccK.-lIcphpG.opuEllcllc+.hP.h...........ss-c+ppsLupphhphh.....+llpps.s.clSppp...LcpLhcKhp...Ksp.............................	0	5	7	10
+4859	PF03669	UPF0139		Uncharacterised protein family (UPF0139)	Bateman A	anon	SWISS-PROT	Family	\N	20.90	20.90	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.48	0.72	-4.51	9	201	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	167	0	134	179	1	98.30	39	82.70	CHANGED	hssssDPRRss+hpRYKPs..oss......-DhhsDYMNlLGMlFSMCGLMh+hKWCuWlAlhCSsISFANsRs.S-DsKQlhSSFMLSlSAVVMSYLQNPpPhoss	........................h..thsDPR.RssplhpYpsPssps..............-D.ssDYhslLuhlFuMsGlMh..+.hKaCuWhAlhhShhS.aANs...+s....opDs.KQ.h.....h.....SS.F..M.......hSl.AlVhoYLtsstsh.........................................	0	46	71	107
+4860	PF03686	UPF0146		Uncharacterised protein family (UPF0146)	Bateman A	anon	SWISS-PROT	Domain	The function of this family of proteins is unknown.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.51	0.71	-4.31	6	77	2012-10-10 17:06:42	2003-04-07 12:59:11	8	1	77	1	56	119	15	127.40	30	93.74	CHANGED	Ml-lAchIAcEst+G.KVVEVGIGhahcVActLpcpG.hDllAsDIscc...pA..pGlphhhDDlhsPslulYcuAchIYSIRPPPElhssll-lu+tVsAshhIpPLsG-.s...pphKLlNY+Gt.FYth-s	......................h....t.pts..+lVElGlGt.p.hcVAttLp.ct.G..h-.VhssDlptp.............ts....tGlp.....hhhDDlh......s....Ps...h.....plYc..sAclIYS..lRPPsELp.sllcl..A+clsuslllpsLus-t........t.h+lhsapt..hYh...............................................................................	0	10	32	47
+4861	PF03685	UPF0147		Uncharacterised protein family (UPF0147)	Bateman A	anon	SWISS-PROT	Family	This family of small proteins have no known function.	21.10	21.10	21.20	27.30	21.00	19.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.87	0.72	-4.11	23	121	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	118	5	81	116	72	84.00	45	95.16	CHANGED	shtss-cpl+pshthL.pcIlsDsoVPRNIRRAAs-uhctLpscppssuVRAAsAISlLD-ISpDPNMPhHsRThIWsllSpLEol+	......h..pscpplcpslthL.ppIlpDooVPRNIRRAAs-uhctLpspsps.uVRAAsAIulL--ISpDPNMPhHsRThIWpllStLEol+.	0	23	47	65
+4863	PF03695	UPF0149		Uncharacterised protein family (UPF0149)	Bateman A	anon	SWISS-PROT	Domain	The protein in this family are about 190 amino acids long.  The function of these proteins is unknown.	25.00	25.00	27.50	27.40	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.49	0.71	-4.39	169	2253	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1277	1	349	1168	204	173.10	26	84.88	CHANGED	hppLpph..Lp.......ttt.h......shsplcGhLsullsu.....stt..lss.ppWl...shlhs.......................pstt.s..pphhphlh...............phhpphtppL......tp.ts.th...................p.hhspp..ps.......tpspslppWspGFltGh...sl.tppp...................pphssp.......hpthlps...lttlupht......ptt.................spcp..tppthtplhE.hh..sshhl......ap.htttt	...............................................p.lsph..Ls.........ppu.hlssAEhcGllouhlsu......spt...h.s...ppWL...shlas......................p.pu.t.h..pchhphlh...............phhsssuppL.....p-.ts..F......................p.h...hspp..-s..........pcsssltpWspGFhtGlul.htsc......................hspl..ss-................htpulcs.....lt.lup.t.......spcp..................spcp....htpuh-cll-hl+hAsLhlashah..............................................................................................	0	58	143	260
+4864	PF03681	UPF0150		Uncharacterised protein family (UPF0150)	Bateman A	anon	SWISS-PROT	Domain	This family of small proteins is uncharacterised. In Swiss:Q9A3L8 this domain is found next to a DNA binding helix-turn-helix domain Pfam:PF01402, which suggests that this is some kind of ligand binding domain. The structure of this domain suggests that these domains oligomerise and due to structural similarities may bind to RNA. The monomer adopts an alpha-beta-beta-beta-alpha fold and forms a homotetramer. Based on the properties and functions of structural homologues of the HB8 monomer, the protein is speculated to be involved in RNA metabolism, including RNA binding and cleavage [1].	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.29	0.72	-4.33	144	2769	2012-10-02 16:06:15	2003-04-07 12:59:11	10	19	1473	7	747	2274	167	47.90	27	43.64	CHANGED	pYssllct...p-css....ahsphP-ls....ush....opG-Th-EAhpphp-Alphhlps	.................Ysshlp.....tccsu....ahsp..hPDl.s........ush....opG-.Th-EAhppsp-Althhlt...............	0	231	511	642
+4865	PF03692	CxxCxxCC	UPF0153; FliB;	Putative zinc- or iron-chelating domain	Bateman A	anon	SWISS-PROT	Family	This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex.  However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.35	0.72	-11.12	0.72	-3.51	35	4094	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	2313	0	1272	3041	657	89.40	24	56.80	CHANGED	hCps....C.GtCCh................htlptpDhtcl.thsth......................................tChhLc.tcst...pCpl.....Yp..pR....PpsC+hhPh....................tththhs.sCs	.....................................Cps....C....Gt.CCh..........................................hp..l....t.p..-...ht.c.l....th..t...t...h..............................................................................................sC......hhL.s.....tcst...........pCpl.....Yp.....pR......PpsC+hh.h............................................................................................................	0	397	784	1044
+4866	PF03672	UPF0154		Uncharacterised protein family (UPF0154)	Bateman A	anon	SWISS-PROT	Family	This family contains a set of short bacterial proteins of unknown function.	20.90	20.90	20.90	21.50	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.03	0.72	-4.35	5	1101	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1097	0	123	358	3	64.60	49	82.30	CHANGED	LsIVLuLLlGlhLGaFISpKhMK+hLKKNPPINEstlRhMhtQMGRKPSEsQINQlM+uhpsQp	...................lllVlAL.l...sGh....lG...GFal.ARKhhpcal..pc..NPPlNE-MlRhMMhQMGQKPSp+KlpQhMptMp+Q.t....	0	36	71	96
+4867	PF03693	RHH_2		Uncharacterised protein family (UPF0156)	Bateman A	anon	SWISS-PROT	Family	This family of proteins are about 80 amino acids in length and their function is unknown. The proteins contain a conserved GRY motif. This family appears to be related to ribbon-helix-helix DNA-binding proteins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.58	0.72	-3.81	5	1166	2012-10-02 18:44:02	2003-04-07 12:59:11	9	7	788	2	292	822	140	77.80	31	88.88	CHANGED	MuKNTSVsLGEHFsuFIDuQVQuGRYGSASEVIRSALRLLE-pETKLcALRsALIEGEcSG-ucsFDhDuFlsE+cpcssp	.......................h.olsL.s-chcpFIcshlp..SGcYsotSEVlR-u...L....R......L.L....c....c....+....E....s.....c....l....p....u....L...R.p....h.l..t...pG....h...p....S...G.......s....p...h....p..p.h.........pth..........................................	0	68	163	215
+4868	PF04229	GrpB	UPF0157;	GrpB protein	Kerrison ND, Finn RD, Eberhardt R	anon	COG2320	Domain	This family has been suggested to belong to the nucleotidyltransferase superfamily [1].  It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme [2].	20.10	20.10	20.40	24.40	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.88	0.71	-4.53	107	1502	2012-10-02 22:47:23	2003-04-07 12:59:11	9	16	1107	1	300	1132	38	162.00	27	79.16	CHANGED	tttlplss.ass.pWsppapptppplpshl....usphl.......plcHIGSTuV......PGLsAKPlIDlhlsVpshpshc..ph.spsLpshGY.h.ht.c.sh.t..............+chFh+......................sp..+stplHlhtt..uss.phpcpLhFRDaLR..scspttppYtplKppLu...tphsp...shptYssuKs..salpclh..pcA	.............................t...l.lhsass.pWtppapc.pptltshl....spthl.......................plcHIGSTul......sslsAKP.IIDIhlt..Vp.shp..p.h.s..ph..tctLpt..l.G....Yhh..t...c...shsp..................+h.h.ht+.........................ttttcsh+lHlhth..sst..phpppLhFRDaLp..spsphsppYsplKppLs......tphst.......shppYspsKssalpplhpc.....................	1	98	188	247
+4869	PF03682	UPF0158		Uncharacterised protein family (UPF0158)	Bateman A	anon	SWISS-PROT	Family	\N	20.40	20.40	20.60	21.10	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.96	0.71	-4.62	3	182	2009-09-11 06:49:59	2003-04-07 12:59:11	8	7	173	0	63	158	12	143.10	24	66.17	CHANGED	QNPLlLRlcRLM-AFAKSDDERDFYLDRlEGFllYIDLDKPQsELDAL.pELEENuDRYCLIPKLSFYEoKKIMEsFVNEKVYDIDTKEKLL-IlQSKcAREsFLEFLYDHcoEQEKWQQFYsERSRIRIIEWLRsNcFQFVFEEDLDhP+pLLEpLK+sLFs	.............................................................................l.h.pl....A..ht.s...s...th.p..haLDh.pG..lh.hl....s....-......................s.....t..-h.....-....th..............p..-.........l.....-...p.............s......s...-.R.Yh.hlP.phs.......h..p.t.hplMcsFlpp.l..t.-.ch+ppL..hpsl.p.u.+s.u.acpF+chlh.-.a.p..hccWhpapscph+thhh-.WLcpptht......................................................................	1	29	50	57
+4870	PF03690	UPF0160		Uncharacterised protein family (UPF0160)	Bateman A	anon	SWISS-PROT	Family	This family of proteins contains a large number of metal binding residues. The patterns are suggestive of a phosphoesterase function.  The  conserved DHH motif may mean this family is related to Pfam:PF01368.	20.70	20.70	22.10	23.00	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.07	0.70	-5.01	69	570	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	459	0	317	545	50	288.60	36	89.24	CHANGED	hpIuTHsGsFHsDEsLAshhL+h.hstat.............sAcllRoRDsphl.spsD..lVlDVGGhYDs...................pppRaDHHQ+sFsthh........p.thsp........+LSSAGLlapHFG+cllpphht.........................hscpp...lphlapplYpsFlcslDAlDNG..lsph...................t...ta..sshoLuuhluphN..PsWs-.t.......t.tsp-ptFtpAhphsup.hhptlcthstshlsA+slVtpAhpptht...sGcIlhL.sp.hsPW+caLaplEp-tth.................h..aVlascs....spWRlpsVsh.pssoFcsRtsLPcsW+GL+D.c-Lsph..........oGIs.GslFsHsuGFIGGscohEusLpMAch.uLp	................................hluTH.sGsFH............sDEsLAshhL+h..ls..tap..............sucl.lRT.RD..s...phl..sps-................lVlDVGG.YDs...................tppRaDHHQ+sFstsh..........tthts.......+LSSAGLlap.HaGcplltphht............................sptp..l..phlapplYp.sFlcslDAhDN.G.ls.h...................t....tat.hshsLushluphN.........PtWsp.t...........................tsp-ptFtpAhphstp.FhptlphhstsalsA+slVt.......pAh.p.p.phph.......p...sGcIlhL...sp..hsPWKc+LaplE..p-..ht...........................hhaVlascp....tspWRlpsVsh.p.so.Fp.sRhsL.Pc.sWRGL+D.cpLsph............oG..Is.GslFsHsuGF..IG.G...scohEuAlphAphuL......................................	0	126	196	269
+4871	PF03687	UPF0164		Uncharacterised protein family (UPF0164)	Bateman A	anon	SWISS-PROT	Family	This family of uncharacterised proteins are only found in Treponema pallidum. They contain a putative signal peptide so may be secreted proteins.	25.90	25.90	26.30	26.20	24.40	25.80	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.91	0.70	-5.90	6	67	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	30	0	13	55	29	294.80	33	72.18	CHANGED	sl....thhshat+suthssuhuhssslushAuusu.h.otpc.Kthu+.....Rsl.lPoGGRapsLssuFTALAsDASFFEANPAGSAshs+sELuhFHsstlssSHsETLSaVtpsGphGYGsShRsFaP-.shp..hu.p............KspGhlu....IhNhu+tF.utYRFKGlSlGuNlKsGaR......................supp.pHlsVsuDlGLphshsVAKsFuScEPNhalGLuh+NlGhoVKs........................................ssssssts.ssstssHsTsohltlGFAYRPlpaFLFulGlphthNVpslpsss..hhuhuFhh..hp.hsh.sshhhpG...tt.thouGuEhp.ssh+ls	................................h......hh.h..hhhshhsh...ssthsu........stt..p.pt.sc.....t.l.lsoGG..RhphLssuFTALAsDASFFEANPAGSAshscsElu.hFHsstlssSHh-Tluastptsph.G.YGsS...h+hFas..sh....h........................pthGhlu....IhNhu+th.ttaRFtGlSlGsNlKhGaR..................................pupt.pHlslsuDlGLphshsVuKsFuSpEPNhalGlshpNlGholps....................................................sstpsc.shsohlhhuhAYpPlphFLFuhGlph.hNlpsl.tt.......t.....p......p....hhuhuhhh.shphlsh.uuhhhpu....tphRhusGuEhphsphpl...........................................................................................................................................	0	8	12	12
+4872	PF03691	UPF0167		Uncharacterised protein family (UPF0167)	Bateman A	anon	SWISS-PROT	Family	The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.	25.00	25.00	28.60	28.30	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.50	0.71	-4.86	11	334	2009-09-11 05:14:47	2003-04-07 12:59:11	9	1	317	0	27	155	5	175.40	52	89.45	CHANGED	hp....LPpF+YHPc..PlsoGuhcps..sssCsCCspspshhYoGshYsh--lp..slCPWCIADGoAAc+a-GsFpDDhslpss................sspphlcElhcRTPGYsuWQQEhWLuHCsDhCAFlGhVGhsEltsL..psl-slhs-ht....sutchpcLhptLs+sGp.hsuYLFpClaCGpahhahDhu	.............sh..psLPpF+YHPc..PLpTG.uF-pD..sVpCsCCcQps..slhYoGPhYsh.....-E.l-...aLCPWCIADGSAAcKFsGoFpDDssl-..ss-.......................hP-EhlcELlcRTPGYpGWQ.Q.EaWLuHCGDaCAFlGaV.G.hs-lcDh...Dt.....hssLccDhc......huh+.p.-ltcsLp+sGc...spGYLFRCLHCGKh+LauDFp........................................................................	0	10	17	22
+4874	PF03666	NPR3	UPF0171;	Nitrogen Permease regulator of amino acid transport activity 3	Marshall M	anon	SWISS-PROT	Family	This family, also known in yeasts as Rmd11, complexes with NPR2, Pfam:PF06218. This complex heterodimer is responsible for inactivating TORC1. an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation.	27.50	27.50	27.60	28.20	27.40	27.20	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.54	0.70	-5.95	19	428	2012-10-01 20:21:22	2003-04-07 12:59:11	8	4	229	0	267	413	2	250.80	23	57.72	CHANGED	GFsschLsplLsPt+phCNp+FElslDslhFlGhPlahtcsGpW+ppcppp...t.ttp.......................................ts..ppttpstp......................t.csshsMFplVFlhN.P.......hhEhs.+lccMacallp+lulsL+apQs+psYVt+EsctILpl+-...th.cpptthps..........hhppllppSSLA+slp-sacuIspscIAsLplss....hhhShQIPhpsch.pLPp.pl.Phh.uoaLoo...................................ts..p.p-th.p...............pthl..aauLLLLcDspsllp-lts.ssss.....hls...................chl+hhpP....shSlhplup..............................ssslsh.splcphAhHLlYWR+ARlI.PLss+ssYlVSP.Aslp..............................pL.pstptFpppFPshPoLPpFLshLS...tpP+sauslIP...S+-H+slYhphLuWLlRaGaVTQLpTFlalhlspcIKhc	.....................................................................................................................................................................................................................................................................................h...h..l..phshhh...p.p.tal.pp.t.h....tp...................................................................................................................h...h......................................................................................................................................................................................h....shhhh..t.............h.................h..............................................hhp..ps.......sh..ht....................................h......h..hs.ahh.htpAhhl..lp...p...hahhss...................................................at..F..s...................L..hlt.hs.................s.......ht..hh.............................................h.hl..hhht.thh......................................	0	88	131	210
+4875	PF03665	UPF0172		Uncharacterised protein family (UPF0172)	Howe K	anon	SWISS-PROT	Family	In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus [1]. This family was formerly known as UPF0172.	24.40	24.40	24.60	25.70	22.60	24.00	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.95	0.71	-4.82	22	258	2012-10-10 14:49:21	2003-04-07 12:59:11	8	3	170	0	158	241	5	183.70	34	92.45	CHANGED	hsplplospAYsKhhLHuhKYPpsuVNGlLluc..........................sspssp............lhloDslPLFH..tplsLsPhLElALspl-sasppps.hsIlGYYpANpph.sDss.ssl.At+lu-+luc....phssAsllhlcNpcls.sscsssht..................lap...ppts+Wspsc.t..hhtptppspchlpph...lpsttapplsDFDsHL-chppDWhNppLsp	.........................................phclospAYsKhhLHuuKYP.p.sAVNGlLlup.......................................................pp..p..ss..p............lhl.sDslPLFH..tpLsLsPMLEl.ALs.......l-s.a.......s.p....p.......p.......u......hsIsGYYpAN...pph..pD..ss....s..s.l..AtKlAs+Is-..........tas.sA.sllh.lDNp+hs..p.ts..sshh..................lhp......ppss+Wpt..pc........t.....h......hp.p..tps....pp..hsuph...lcsps..appLlDFDsHLDDlppDWhN.tl..............................	0	63	85	119
+4876	PF02476	US2		US2 family	Mian N, Bateman A	anon	Pfam-B_2256 (release 5.4)	Family	This is a family of unique short (US) region proteins from the  herpesvirus strain. The US2 family have no known function. 	25.00	25.00	30.80	29.80	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.97	0.71	-3.65	15	202	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	32	0	0	136	0	150.10	66	66.65	CHANGED	hLsSshsss.psaHLWVlGAADLCtPsl-plsss+...RLlssclsssWs.GtsW.lPs.......phtshhTss.........Ws.........Ph.sssps...ltss.sshchhYullss...................s.h.Psssspssspsssps.....spssCsss	....HLNSSLIIN.QPYHLWVLGAADLCKPVFDLIPGPK...RMVYAEIADEF..HKSW.QPPFVCGKLFETIPWTTVE..................HNHPLKLRAAGGEDTVVGECGFSKHSSNS..LV+PPTVKRVIYAVVDPARL.......REIPAPGRPLPRh......R.....PSEGGMRAPRRRSRA..PAPARSTAs..AAs..........................................................................	0	0	0	0
+4878	PF03683	UPF0175		Uncharacterised protein family (UPF0175)	Bateman A	anon	SWISS-PROT	Family	This family contains small proteins of unknown function.	26.40	26.40	26.50	26.50	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.23	0.72	-4.51	47	419	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	182	0	161	473	43	71.90	24	80.33	CHANGED	plPctlh.shp.s.pth.pEl+htlAlpLYppstlShG+AAclAGl.o+hcFhchLuc+sls.hp..hs.c-LpcDlpss	.....................................th...ht...t.t...pch+hthAlpLY...ppsclShupAAclAGh.sch-Fh.phLtccsls.hp...h.s..--lpp-lp..h..................	0	47	129	154
+4879	PF03698	UPF0180		Uncharacterised protein family (UPF0180)	Bateman A	anon	SWISS-PROT	Family	The members of this family are small uncharacterised proteins.	22.30	22.30	22.60	27.90	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.42	0.72	-4.14	18	218	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	204	0	53	136	0	78.90	47	96.57	CHANGED	hp+.IuVEpuLoslp-tL+p+GY-Vlplc....spp......chpssDssVVTGhDsNhhGIpDssTpu.sVIcAsGhTA-ElsppVEp+lp	......t+IGVEsoLo.cVppALpppGaEVVsLp.....scp.......DspuCDssV...VT...G.......pD........o.N...h..hGI...sD.ssh.cu.sVIsApGhTs-EIsppVEsR..t....................................	0	25	42	46
+4880	PF03701	UPF0181		Uncharacterised protein family (UPF0181)	Bateman A	anon	SWISS-PROT	Family	This family contains small proteins of about 50 amino acids of unknown function.\	      The family includes YoaH Swiss:P76260.	22.20	22.20	22.70	22.20	21.10	22.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.51	0.72	-4.66	18	721	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	718	0	66	197	1	51.70	70	86.32	CHANGED	Mh.sshPuLoHEpQQpAVE+IQcLMucGhSSGEAItlVApElR.Ep+ppcppst	....MF.AGLPSLTHEQQQKAVERIQELMAQGMSSGpAIAlVApELR.AsHoGE+I.VA......	0	4	20	46
+4881	PF03670	UPF0184		Uncharacterised protein family (UPF0184)	Bateman A	anon	SWISS-PROT	Family	\N	20.90	20.90	20.90	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.81	0.72	-3.81	3	137	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	118	0	63	90	1	73.80	36	65.06	CHANGED	MSGPNGDsshSVEDGups--D-FGppEYEAINSMLDQINSsLDcLEERNDcLpu+L+ELLESNRQsRLEFppQLu.cAPp-uSs	..........................................................................................p...p..hAtlNSpLDQLNSsLD+LE-+...sDHLcupL+pLhp........................pt.........................	0	17	22	38
+4882	PF04050	Upf2		Up-frameshift suppressor 2 	Wood V, Finn RD	anon	Pfam-B_14721 (release 7.3);	Family	Transcripts harbouring premature signals for translation termination  are recognised and rapidly degraded by eukaryotic cells through a  pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3)  are required for nonsense-mediated mRNA decay [1].	25.00	25.00	25.00	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.20	0.71	-4.49	16	283	2012-10-11 20:00:59	2003-04-07 12:59:11	9	11	232	2	203	287	0	170.80	27	16.56	CHANGED	cussSss--Gh.....---shs-t-c-p-....So-Ec-sstsssppst.....co-uE-EplhVoRpp--hDPEsE..AEFDREF-KMMu..................ESh-SRKaE..++ssFDlPLPM+htscsss.......ssspsssE......tssssssTMsFoLhTK.KGNKQQTRsl-lPSDSohAhuM+sQQpA-pEEQQRIKpLVLN	................................................................................ttts.......ps........-ppt.......p.t...-...p-cp...........ppc.-p.p...p.pt..p....-..ttppp.......................psp.p-.cpp.hh......l...pt...t.t.......p..hs...s.p...t-....t-F.ppth.pKMht....................................E.u..h......p...p.RphE....+h..tt.....h..Dl....s.l.......Ph..phpsptpp...........................................ts..t-..................spstsssshsFslLo+...+GNK.QQ.........h..+plplPssSphAhshhpp.ppA...-p-E+p+lKpLsLp..................................	0	60	102	165
+4883	PF01255	Prenyltransf	UPF0015;UPP_synthetase; 	Putative undecaprenyl diphosphate synthase	Finn RD, Bateman A	anon	Prosite	Family	Previously known as uncharacterized protein family UPF0015, a single member of this family Swiss:O82827 has been identified as an undecaprenyl diphosphate synthase [1].	20.60	20.60	20.90	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.40	0.70	-5.22	94	5931	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	4761	48	1691	4210	2997	213.10	40	85.11	CHANGED	I.MDGNtRWA+p+....shs.pttGHptGspslccllchshch..GlchlTlYAFSsENa.pRspp.EVshLhpLhpphl.pc.hpphp...p...psl+l+hlGch.stL.sppltptlpcspptT.p....sss.shpLslAlsYGGRpEIh..........cAs+plh...............................................pth.tspls.pp...................................................lsc..ph....l...pptLhs..ssh.P............s...DLlIRTSGEpRLSNFLLWQsuYuE..laFscshWPDFsttchhpAlppYptR...........pR+FGt	.............................................................................................IMDGNGRWA+p+....s.h.s....Rs....h....GH...........+tG...hc.sl.cchlphst.ch....GlchLTlYAFSo...ENW.pRP.pp.EVshLMpLhhphl.cp..l.tph.......p....c.....psl+lch.l.G.ch...s..p..L..sppltctlppu.....p...p..h.T...t......................s.Ns....u.......lpLsl.AhN....Y....GG.RtEIs..........pAs.+pls......................................................................................................pp..s...t..p...u.p....l.p....s...p..c..............................................................................................IsE....ch....l.spaLhs....ssh..P...........cs.DLlIRTSGE...p.Rl..SN.FLLWQhAY...uE...h.............aFo.-..sLW......PDFscpc.hhpA.....ltpapp.R.cRRFG.s..............................................................................	1	575	1096	1447
+4884	PF00449	Urease_alpha	urease; 	Urease alpha-subunit, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain is a composite domain and plays a major  trimer stabilising role by contacting the catalytic domain of the symmetry related alpha-subunit.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.56	0.71	-3.97	117	1905	2012-10-03 00:45:34	2003-04-07 12:59:11	15	17	1537	48	464	1638	555	117.10	58	20.98	CHANGED	hclsRptYAshaGPT....sGD+lRLuDT-LhlEVE+DaT......sY............G-EspFGGGKVIRDGMGQuptsssst......sl..DhVITNAlIlDa.hGIlKADIGIK-G+IsuIGKAGNPDh.sGVs................lllGsuTElI	.........................h.ploRptYAshaGPT....sGD+lRLuDTsLhlElE+Dho.............sY.................G-Esp.FGGGKsIRDGMGQuptsst-t.........shDhVITNAlIlDa..h.........G..I..lKADIGIKcG+IsuIGK.AG.NPDl...sGVs................lllGsuTElI..................	0	139	288	388
+4885	PF00699	Urease_beta		Urease beta subunit	Bateman A, Griffiths-Jones SR	anon	Pfam-B_405 (release 2.1)	Domain	This subunit is known as alpha in Heliobacter.	25.00	25.00	36.20	30.30	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.02	0.72	-4.16	165	1820	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	1525	48	471	1322	409	99.30	54	51.53	CHANGED	IPGElh.s...ssGc...IpLNsGR.p..slslpVsNoGDRPlQVGSHYHFhEsNsA.LpF.........DRptAhGhRLsIsAGTAVRFEP.Gpp+pVpLVshuGpRplaGFsuhltGtL	..................lPGElh....h...ts..s.-......IplNsG....+...t..shslpVtNoGDRPlQVGSHaHFaEsNsA.LpF.............DR....ptA.....hGhRLDIsAGTAVRFEP.Gp..p+pVpLVshuGpRplaGFpuhlsG..........................	0	134	289	393
+4886	PF00547	Urease_gamma	urease_gamma; 	Urease, gamma subunit	Bateman A	anon	SCOP	Domain	Urease is a nickel-binding  enzyme that  catalyses the hydrolysis of  urea  to  carbon  dioxide and ammonia.	23.90	23.90	24.10	24.70	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.08	0.72	-3.97	85	1774	2009-01-15 18:05:59	2003-04-07 12:59:11	13	11	1506	51	477	1161	409	96.50	60	54.59	CHANGED	McLoP+Ep-KL.llasAupLAc+R+sRGLKLNaPEAlAlIostlhEG.ARDG.+..........oVA-LMshGpplLsc--VM-GVs-Mlp-lQVEATFPDGTKLVTVHsPI	..................McLTPREpDKL.hlhhAA.lAcRRpuRGLKLNaPEAlAlIostllE..........G.....ARDG.+................oVAELMphG..pplLs.................+-DVM-GVs-MIs-lQVEATFPDGTKLVTVHpPI..............	0	139	295	399
+4887	PF01774	UreD		UreD urease accessory protein	Bashton M, Bateman A	anon	Pfam-B_1109 (release 4.2)	Family	UreD is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid [2]. UreD is involved in  activation of the urease enzyme via the UreD-UreF-UreG-urease complex [1] and is required for urease nickel metallocenter assembly [3].  See also UreF Pfam:PF01730, UreG Pfam:PF01495. 	20.40	20.40	22.20	22.00	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.25	0.70	-4.85	163	1645	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	1448	2	449	1350	498	205.80	23	73.12	CHANGED	pshllpsu..GGlluG.Dplslslplsssu+shlTT.tuAsKlY+..........................u.sut...............................up.QphplplsssAtL-aLPp-sIhFssuphppphplcL...........sssAphlhhEhls...hGRs..u.tG..................................Epa........shsph.csphclhp.....ss..........c..l.hh.-phtL.psst.........tthss.ssh.........suhsshuollhhu...................ts.......p.th.hptl+..thh.......................t.th.hGs.ohh........sshlllRhLusssps...l+phh	..............................hhllssuGGlluG.Dchplslpl.pss..upshlTo.puAoKlY+.............................s..sst.................................................up.QphplplsssuhL-alPpssIsap.sAchtppsplpL......................pssupllhh-hlshGRs..s.pG..................................Eta........phsthpsphclhh.......cs....................ch...l....hh..-phhL.sssp.............t.hst...shh.................................................tshshhuolhhls.................................................................p.thhptlp....thh.........................t.sh..th.uh.otl............sshlhlRhhu.pst.lpth.h...................................................................................................	0	123	268	370
+4888	PF05194	UreE_C		UreE urease accessory protein, C-terminal domain	Finn RD	anon	Pfam-B_6279 (release 6.1)	Domain	UreE is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.	21.90	21.90	21.90	21.90	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.28	0.72	-3.88	99	1267	2009-09-11 21:12:50	2003-04-07 12:59:11	7	3	1165	35	255	871	383	91.80	29	53.94	CHANGED	sEslhplpu....ss.hpLs.........+hAaHLGNRHlPh......pltss.....tlhlt...tD+VlccMLct...........L.G.....hplpphptPFpPEsGAY..................tt...ctHs..........................HsHs	........................Ecllhlps.....p.sh.hphu.........clAacLGNRHlPs............plpps..........clhl.........hDtll.cchLcp..................................L.G.................hss.pctct..Fpstttsh..............................................sHsH....................................s................................................................................	0	59	142	201
+4889	PF01730	UreF		UreF	Bashton M, Bateman A	anon	Pfam-B_2037 (release 4.1)	Family	This family consists of the Urease accessory protein  UreF. The urease enzyme (urea amidohydrolase) hydrolyses urea into ammonia and carbamic acid [2].  UreF is proposed to modulate the activation process of urease by eliminating the binding of nickel irons to  noncarbamylated protein [1].	20.50	20.50	20.50	23.20	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.52	0.71	-4.08	171	1651	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1481	11	435	1261	476	150.00	22	63.76	CHANGED	hVpc..tsslpsWlpshLppshspsDsshLttsac.uhtt.........sDh......ttltplsphhhAtptotEhRtpspphGtuhhclhsp.......................h.tts.....ssh.................................................sasluauhsutthslshppsltuaLauhlpNhlsAAl+llPLGQssuQclLtpLps....h	..........................................................................h.lpcttshttalpthLp...phs.hs-t..hhlt.tsac...Ah..tt.............................sDh.......ttlhclsphhhAp.p..s.cEhRttspphGpph..hcl..htph.....................................htp.thtptp...........sps....................................................................shslshuhhut..............thuls.........hcpsltsahauhspshlpAAlRhlPLGQhsuQcllhplt..h..............................	1	117	257	356
+4890	PF04115	Ureidogly_hydro		Ureidoglycolate hydrolase 	Wood V, Finn RD	anon	Pfam-B_9183 (release 7.3);	Family	Ureidoglycolate hydrolase (EC:3.5.3.19) carried out the third step in the degradation of allantoin.	20.60	20.60	20.60	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.42	0.71	-4.90	81	1067	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	957	8	269	684	700	164.00	40	89.59	CHANGED	h.pp..lp..scPLTt-AFAPFG-VI-s.p................uss.......shhINpGpstRaH-lApl-s.s........su+shlSlFcu.pPpsLP...............................hplchlERHPhGSQAFlPlss.ps..................aLVVV.As..ss.............................................................ssss.sph+AFlssssQ....GVNYt+GsWHtsLhsLs....tsucFhVV......DRh.Gs.....us...Nh-Ehhhsp.shtlp	.................................................................h..pLpl.PLopEAFusaGDVIEs..p..........................ttc...........hhhIN.sGhspRaH.DLAhl-hht...................psRslISlhRu.pP.ts.hP.................................................lslchLERHPhGoQAFlPhpu.cs...........................................FlVVV.A....s.s..............................................................-tP.c....uslRAFl..ss..GpQ....GVNYc+sVWHH.PLhuhp....pssDFlsl........DRu.us.........NC-..ths.......t..................................	0	68	139	207
+4891	PF01014	Uricase		Uricase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1333 (release 3.0)	Domain	\N	25.00	25.00	26.00	25.80	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.72	0.71	-4.09	122	880	2012-10-01 20:59:24	2003-04-07 12:59:11	13	3	380	220	499	906	5	136.40	24	88.46	CHANGED	php.GhsslplLKss...........+hosh...pc+lhpssVssphph.....t..t.sh.hpucs....ssh..shsss..................pcsoltsaAt.......ssSlpphhhphupchL.sphsp.lpslplplssp+ahc...l........sh.pG...........................cu.lhtsscp.puhlps	..........................t.hp.GhsslpVlKss...........+.ssh...tccl.hshsVssphph..................p..htt.sh...hpucs......ssh...shscs..................p+sslhsaAt..s.....ssSlp..phhhplupchL..sph..sp..lppsclpls.s.tcahp..h.......................sh.tG...........................t.....scu.lhhsscp.hs.lp...............................	0	154	286	410
+4892	PF01208	URO-D		Uroporphyrinogen decarboxylase (URO-D)	Finn RD, Bateman A	anon	Prosite	Domain	\N	23.90	23.90	23.90	23.90	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.88	0.70	-5.52	173	4750	2012-10-01 21:20:02	2003-04-07 12:59:11	12	17	3576	28	1416	3843	3275	317.70	30	91.34	CHANGED	ht.........pcthlpAhpG.cs.s-..........+sPlWhMRQAGRhlsEYpth+t..stsah-hs.psP-lsuElolpPhcpas..hDAuIlF.....uDI.ll.scAhGh.plphhp.sp......G..Phlt....pslp..........s....p-...lp..pL...........ph.ts......t..lshVh-ulphl+c....cl.....ss....clPLIGFsG...uPaTLAsYhltGtssp..shpph+phha......pcPchhcp.Llchls-sshpYlpsQl.cAGAp...slplFD....oauuhLuspp....accaslPah.p+lhstlcphh...............thPlIhaspGs.....s...hlpths..c....sG.s-...s.lul...................Dhps.......sl....stsp..........................................ph.....slQGNlDP.shLh....us.ctlcp.......cspchlc...........httttsaIhNLGHG...lsPpsss-slpthl-sl+ph	.....................................................................................................................h..pphhlcAhht..p...ss...................hsPlWh...MRQ............AGRhh..........PEYpth+t...ths..hh.ph.s....pss...-..l..ssE...lT.l..pPlcpas....hD.A.A.IlF.............SDI..hs...p.u.h.Gh.sl...th...t..ut..........G......P..hh.p......pslp........s..........htD....lp....pL...................................t..ss..............clshVhculchl+c...........cl......tt..........................cl.P...L.I..G...F..s.G.........u..P..a..T......L.A.s.Y.hl..EGts.........S+sapph....+.t.h.h.a......pcP.p....h...h+t.L.Lc.pl.scssh...t...Y.Lp........s...Q......l....c......A......G...A.p.................u.l.l...FD.............oW...u..G....h....L...s....s.......ps..............a.ppFsh.sah.p+l.l.stlp..ppts............................PlllF.s.p.Gs................u.t....hlp.ths.....p........sG..sD.......s...lG...l.....................D.W..p..s.........s.l......cstc......................................plu..sphsl...Q.G......N.h..D...P......s.h.Lh....u....s........p...t...l.cp..................clppllp...........hststG.alh.NLG....H..G...l...h..s..p...ss..sE...plpthlctV+p.h..............................................................................	0	553	997	1240
+4893	PF01175	Urocanase		Urocanase	Finn RD, Bateman A	anon	Prosite	Family	\N	23.20	23.20	23.20	23.50	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.66	0.70	-6.47	57	1993	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	1787	16	520	1576	698	525.80	53	93.68	CHANGED	.l+....As+G.....spLs..sKuWhpEAshRML.NNLDP-VAEcPc-LVVYGGhG+AARsWpsa-tIlcsLccLcsDETLLlQSGKPVGlF+THtsAPRVLIANSNLVPcWAsW-cFpcL-ptGLhMYGQMTAGSWIYIGoQGIlQGTYETFstsuRp+aG....G........sLpG+hhLTuGLGGMGGAQPLAssMsGusslslElDpsRIc+RlcptYLDchscsLD-AlthhccApppt.cslSlGLlGNAA-lhscLlcR.....Glh.....PDlVTDQTSAHDPlp.GYlPtGhol--hpchpp..p-P...pthhptucpShscHVcAMLthpptGs.sFDYGNNIRphAh-t.Gl..csA...........FcaPGFVPAYIRPL.FCcGhGPFRWlALSGDP-DIh+TDptlhELhP-sc+L.............ppWlchAc-+ltFQGLPARICWlGhG......-Rt+hGLtFN-MVtsGELpAPlVIGRDHLDsGSVASP.RETEuMtDGSDAluDWPlLNALlNsAuGAoWVSlHHGGGVGhGhS.HuGhVlVsDGT-tAscRlpRVLssDPuhGVhRHADAGY-tA.hpsA+-.ps........lclPhhp	.........................................h.l+A.pGsplp..sK..uW.sEAshRMLhNNLDP-VAEpPc-LVVYGGhG+AARNWpsa-tIlcsLcpLpsDpTLLVQSGKPVGlF+THpsAPRVLIANSsLVPcWAsW-+Fp-L-ppGLh.MYGQMTAGSWIYIGoQ......GIVQGTY.........ETFspsu.RpHas........................G......sLpG+hhLTuGLGGMGG.AQPLAushAGusslslEsDpoRI-hRlcptYl.Dchsss.LD-ALshh..................pctpc.pt.cslSluLhGNAA-lh.cllc+........slp.....sD.llTD..QTSAHDPls.G.YlPtGhohE-hpphtp...p..D..P..pthhctucp..SMspHVcAMLshppt.Gs.sFDYGNNIRphAh-.t..Gl..csA...................FcFPGFVPAYIRPL.FCcGhGPFRWsALSGDP-DIh+TDttsp-.lhs.-.s.c+L............................apWlchAcE+ltFQGLPARIsWlGht...........................pRt+lGLAFNEMV+sGElp.APlVIGRDHLDsGSVASPNRETEuM+DGSDAVuDWslLNALlNoAuGAoWVSLHHGGGVGMGaS.HuGhVlVsDGo-cAscRlpRVLtsDPusG..VhRHuDAGY-hA.lcsApE.ps........lplPh..t...............................	0	165	289	419
+4894	PF02083	Urotensin_II		Urotensin II	Mian N, Bateman A	anon	IPR001483	Family	\N	18.60	18.60	19.30	19.30	16.80	15.80	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.31	0.73	-6.26	0.73	-4.32	8	70	2009-09-10 16:31:46	2003-04-07 12:59:11	10	1	37	0	27	66	0	11.70	67	10.48	CHANGED	ssss-CFWKYCV	.....tsps-CFWKYCV	0	2	5	12
+4895	PF02393	US22		US22 like	Bashton M, Bateman A, Zhang D, Aravind L	anon	Pfam-B_1016 (release 5.2)	Family	US22 proteins have been found across many animal DNA viruses and some vertebrates [3]. The name sake of this family US22  Swiss:P09722 is an early nuclear protein that is secreted from  cells [2].  The US22 family may have a role in virus replication  and pathogenesis [1]. Domain analysis showed that US22 proteins\	      usually contain two copies of conserved modules which is  homologous to several other families like SMI1 and SYD (commonly  called SUKH superfamily) [3]. Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins [3]. 	35.00	35.00	35.10	35.00	33.50	34.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.58	0.71	-4.10	36	718	2012-10-01 20:46:44	2003-04-07 12:59:11	11	4	53	0	8	635	0	131.60	19	44.51	CHANGED	sttshtslpphsccppGpplslstst.....thhlhlsshpshh..............tttthpphttthl.spspphhllGhlsp..s............................................................................................................hsphllllsptGpVYsacs..............cplahlA.sslppFhctGlhphtthh	...................................t...s.ttlpphlpchpGpplsLthPt.....shhlhl.s..stpphh...................stphhpphhpt..hh.s..tsp....th.hslGslsthts....t......................................................................................................................................................................................psphl...llls.ptGpVasac.s.tp..............sp.lahlA.cslppah+.hGlhph....h..........	0	3	3	8
+4896	PF00577	Usher		Outer membrane usher protein	Bateman A, Desvaux M, Eberhardt R	anon	MRC-LMB Genome group and Prosite	Family	In Gram-negative bacteria the biogenesis of fimbriae (or pili) requires a two- component assembly and transport system which is composed of a periplasmic chaperone and an outer membrane protein which has been termed a molecular 'usher' [1-3].  The usher protein is rather large (from 86 to 100 Kd) and seems to be mainly composed of membrane-spanning beta-sheets, a structure reminiscent of porins. Although the degree of sequence similarity of these proteins is not very high they share a number of characteristics. One of these is the presence of two pairs of cysteines, the first one located in the N-terminal part and the second at the C-terminal extremity that are probably involved in disulphide bonds. The best conserved region is located in the central part of these proteins [4-5].	18.90	18.90	19.70	19.00	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.58	0.70	-5.79	34	6892	2012-10-03 17:14:37	2003-04-07 12:59:11	15	21	937	10	466	4642	66	502.70	31	67.01	CHANGED	ahshpsGlNlGsWRLRsss..oaspspsp...........ttpappsphaLpRulspL+ucLslG-shTsuclFDohsFpGspLsSD-sMlPss.RGaAPsl+GIApo.sA+VTlcQNGhlIYpphVPPGPFpIsDl.sssss...GDLpVplpEpDGshppasVPhoolshhhR.Gph+YslsuGchcss......sppppsshFhpuohtaGLstshTlYGGshhup.cYpuhuhGlGtslGshGAlShDsTpupuphsspp.....scpGpSa+hpYsKshstssTslplsuYRYSocsahohs-hl.sp........................phphsp+..sphplsloQsl.us.....usl.lsssppsYW..........tssssspphpsuassshts.lsholshShscsptpppt.....DptlulslSlPhsph.s..............hhuohshspspsupss.psGl.Gshh.cpphsYslptuhsssspps....sshshsapushuplsuuhsasps...pphshulSGuhluasp.Glshupths...sThsllcssG.suGstlss....uspTDhpGhuVlshhssYppNplslDsssLPssl-lppsstpVlPTcGAlVhspF	..................................................................................................hthpsGlNlGsWRlRsps..s.a.spss.sp.......................tpap..ptah....pR....sl.slp.upL.tlG-.s.h..o.s...u...s..l...F.D..o.hs.a.p.GspLtoD.cpMLPss.pGa.APh.l..pG..lA.p...o..sApVolpQNGhhIYpotVsP.GsFtIsDL..sssss.....................GDLpVslcEsDGp..ppa.plPa.uol.P.hh.R.Ghh+Ysl...ssG....ch+st...............sttp.p...ps.Fhpush...aGls......s.shT...........h..Y......G.Gh.......hu...p..pYpuhs..hG.h..Ghs..h.......h.G..A.lShD.sTpup.u......p...h....s.s..tp.............p.pG.....p.....Sh.....R.h..t...YsK...p..h....s...p...o...s..T...sh..p....l.s..u..YR....Y.S.o.p.s.a.hshs-hh.tp.t..............................................p.ths..p..+......sphphslsQ.sl..st........huolhl.o.h..s..p..p.........s.YW..............sss....s..pspph.phu..as.s.....s..h.....t....t.....hs..h..ol......uhs....hsp.....st.....pppt......................-phh...l...sl....Sl.Phsth......................hohs.h..s.p.s..p.p..u..t...s.s.p...p..h.ulsG...shh....s...s...p...h...sYs..lpt.uhsp..p..sspss.........ssushsap.us...h..up..h..ss.......u....h......s....h.....s....p.....s..........p.........p..hs....h....uh......s..........Gul......l..s..a..st..G.ls.h..u..p..hs...........-Thsll.c.......A.....s.G...s..t..s..s........l......p.....sp........sstTs..hh...G...huVlshhosYppN...plslDss.s.l....s.s..s.s-l.pp.s.s.tp.lsP..s.c..GAlshspF...............................................................................................................	0	58	144	319
+4897	PF04871	Uso1_p115_C		Uso1 / p115 like vesicle tethering protein, C terminal region	Kerrison ND	anon	Pfam-B_6073 (release 7.6)	Family	Also known as General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [1].  p115  tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal  acidic region.  It is required for intercisternal transport in the golgi stack. This family consists of the acidic C-terminus, which binds to the golgins giantin and GM130.  p115 is thought to juxtapose two membranes by binding giantin with one acidic region, and GM130 with another [2].	22.20	22.20	22.30	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.88	0.71	-4.23	6	224	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	191	0	157	229	1	127.70	25	12.86	CHANGED	tclpsEuptppshAAKhh-h-s+h.tph.suLtQtpppLcpE.....hKuLpt...s..t...tcsspphsplcslKpcLctE.........u.p-ucsEh-DLLlLLuDp-pKlp+hcu+Lp-LGh-V..--......tD-u.tsp--D--E	.........................................................................t...............ttt....-.p.....ph...............s..t.L..p.t.p.pp..hcpc...................hctLp....c...t.....p.....t....thp.pp...h........pptpsp..h.s..t..........L.p.s.t+pc...L..c...t.E................................s.p..c..s..cp....E.-DLLlLLuD.-pKlpphKp+LK-LGp.pVp---........t.p..--p.-cppt....p.............................	0	37	75	124
+4898	PF04869	Uso1_p115_head		Uso1 / p115 like vesicle tethering protein, head region	Kerrison ND	anon	Pfam-B_6073 (release 7.6)	Family	Also known as General vesicular transport factor, Transcytosis associated protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [1].  p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region.  It is required for intercisternal transport in the golgi stack.\	This family consists of part of the head region. The head region is highly conserved, but its function is unknown.  It does not seem to be essential for vesicle tethering [1].  The N-terminal part of the head region, not within this family, contains context-detected Armadillo/beta-catenin-like repeats (Pfam:PF00514).	25.00	25.00	27.70	25.80	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.77	0.70	-5.67	26	295	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	240	4	205	303	1	289.20	30	29.08	CHANGED	GNtphQppFuplsV........s.h-...ss.........s..lsVl.sLLphhLt.ssh...psaDlRsAushClcuYhhsNpphptpFLpptIsuapsss..............................................s.psN....lhssLht..p.ph..sh-PYphWFuullLhHllh-sscs....KphhhpV......t..pGspssGE-slosIQs...........loslLlsslp.spD....................RlslGYLMLLssWLac-.sAVs-FLu-toslpsLls......sppssspsslVpGLsuhLLGlsYEFS.opsSPhsRtcLapLlhpplGp-sYhsKlppl+cpslapchp...psphshs.cp..tLP.........-laFDphFlcLhK-sasRlp+Al	................................................................................................................................st..Q-.Fuplps..................................s...ss.shsslssLLh.hlpp..p.............pshslRsAshhChps..ahhcNppsptpllps..h...lsuphsss..........................................................sthss..........lhssLh................ssDs...hps...Wh...AuVhLhHhl.-sspt....Kc.hhcV..................................phss.s.......G..ptslo...hlQp............hs.shL..p.....t....s.sc...............................................phplGhLhLLssWLhpss.AVscFLp..............psuslthLhtt............spp.s.p..pc.ll..pGLsAhLLGlsh.Fs.sp...s..s................hs+p.....plpplltpRlGp-pahp+lstlpcp.hapchp.........p.phstsp......................................phhFDppFschhKc..uhlh+ul...............................................	0	68	111	170
+4899	PF00582	Usp		Universal stress protein family	Bateman A, Griffiths-Jones SR, Kerk D, Studholme, DJ	anon	MRC-LMB Genome group	Domain	The universal stress protein UspA Swiss:P28242 [1]  is a small cytoplasmic  bacterial protein whose expression  is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during  prolonged exposure to such conditions, and may provide a general "stress endurance" activity.  The crystal structure of Haemophilus influenzae UspA [3] reveals  an  alpha/beta fold similar to that of the Methanococcus jannaschii  MJ0577 protein, which binds ATP [2], though UspA lacks ATP-binding activity.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.68	0.71	-3.99	231	22843	2012-10-02 18:00:56	2003-04-07 12:59:11	21	106	4199	94	7308	17012	1965	137.10	18	62.93	CHANGED	hhc+llVuhD..soppup.pAlphAhp...hupp..tstlhllaVhsstshtttsthhttttttthttttt..................................t.thhthphhhhtssssptlhphscptss-llVhGspu............hsshpc.hl...lGS.ssppllcpuss..PVll.l+	.........................................................................................................................................................pplllsl..D.........so.pp.....up......p....u....l..c..tAhp...........................hApp........s....u.....p....l...p.l....l....p..l.....h......s......s.........s.....h...t....h......s...t.....t..h....t......h.....t...h...t...t...t..h.t..t.t.t...t.tt.............................................................................h.t.t.h.s.t..h.....p..h..h...l.......t.....t.....u.....s.....s....t.....p....s....l.h..c....h.............s.........p.....p....t.......s..........s.........-.......l.lVhG.sps.............................ts.s..hpp..hh..............lG.S...su..ppl.l.p.....p...u..p..s...sVlll...............................................................................	0	2051	4696	6329
+4900	PF03253	UT		Urea transporter	Bateman A	anon	Pfam-B_3193 (release 6.5)	Family	Members of this family transport urea across membranes. The family includes a bacterial homologue Swiss:Q9S408. 	25.00	25.00	26.30	26.30	19.50	22.30	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.92	0.70	-5.53	26	784	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	618	6	188	566	13	275.00	32	84.53	CHANGED	phl.....-hlLRGluQVhF.NNPlSGLlILhulhl.....psshhulsullGslhSTLoAhllstc+utIssGLaGaNGsLVGlhluhF.sh........hsh.hhhlhhsuhhssllsuu.LtslhspaclPshThPFslsshLh..lhust+hs.h.st..h........pPssstss.shsthsls..phlpulhhGlGQVahpsNsloGhlhLlulhlsS.lhslaAllGSslGhlsu.LhlusshsslhtGLaGaNslLsslAlGuhFhhhshpotLhulhsslhsshltsulu.hhtslGLPshThPFslsoh.hhLlsssphphhc	........................hlchlL+uhuQVhh.sNshoGLhlLlulhl.....ss.tl.uluuhlGollushhAh.......hls..h......s..c.............s.pl..psGLhGa...NusLsulslslFhst.............phhhlhh.shluohhsshlssA.lp.p.l.....h.p.....a.....clPshThPFllssW.hh....lhh..ssth.phh....sshhh..................hPt......tss.....h.s..ph.ph..................phlpulh.GhuQVahts.s.s.luGllh.llGlhIsShhsulhAlluShluhhhs..hhL.....uu....s...............hss.....It.tGLa..GaNslLsuIAlGshF.t..s.h..p.shlhslh....u.s.lho.sh.lp......huh......sshhtshGlP.shThPFllsoW.lhLhss......................................	0	43	66	119
+4901	PF01099	Uteroglobin	Uterglobin; 	Uteroglobin family	Finn RD, Bateman A	anon	Prosite	Domain	Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be  elucidated [1].	24.80	24.80	25.10	24.90	23.80	23.30	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.16	0.72	-4.17	32	271	2012-10-01 20:54:19	2003-04-07 12:59:11	12	1	46	12	118	280	0	65.00	24	72.61	CHANGED	Cssltphlpthl.s..o.spYct.LppapssstshpAttplKpCsD.phopcs+tpltphhtpIhpS......hC	................Cshh.phlpthl.s..o.stYcthLppasss.tshpAhtplKpCsD.pls.c.s+tpltplhttlh...................	0	9	9	22
+4902	PF03998	Utp11		Utp11 protein	Bateman A, Wood V	anon	Pfam-B_6404 (release 7.3)	Family	This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA [1]. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome [1].	25.00	25.00	26.30	25.90	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.92	0.70	-4.55	50	346	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	301	0	243	331	3	230.20	32	92.06	CHANGED	++sH+ERuQPpsRp.+hG.lLEK+KDYphRAcDY+cKpppLKtL+cKAtp+NPDEFYatMhssKssc........Ghthtppt.....spthoh-pl..+LhKTQDhsYlcpptps-t+Klc..+hpppL..h..s.tsps................................................+HhlFsDscc-.pphp.tph........................possphlscpps+..p.ptlpt..h...........................t..pphpppptpphppLpp+hpRpcpLpplppchphp+clh..ppt..ppp+lhtsp..............................sssha+a+tpRKR	..............................p+pH+ERuQPttRp.+hG..lLEK+KDYphRAcDa+cKpppL+tL+cKAtp.+NPDEFYatMhss+sps...........Gh+htppp.................................pcpho.-.pl........+Lh+TQDhtYlchptpt-t+Kl-.+LpppL.....th.hsht...sps...................................................................................+HhhFsD.s.cc.......Ehc.p......hp.tp.hh...........................pstsphhsct.sc........phppltp...............................t.tthpphtcppppphppLpp+hpRtppLthhtpchp..hp+thh..........t.t.....phh+h..h.tt.t...............................................t.shahahtpRK+...........................................................	0	84	134	201
+4903	PF04003	Utp12		Dip2/Utp12 Family	Wood V, Bateman A	anon	Pfam-B_10105 (release 7.3)	Family	This domain is found at the C-terminus of proteins containing WD40 repeats.  These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2 Swiss:Q12220 [1].	26.00	26.00	26.00	26.00	25.90	25.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.08	0.72	-4.15	96	902	2009-01-15 18:05:59	2003-04-07 12:59:11	7	30	298	0	660	885	5	107.30	20	13.59	CHANGED	s-pphlppll.pslssspIctsltpLPhsal.pLLchlsphhp.pps.....+lphhhtWlphllptHup.lssp...........................plhspLpslpphlppphpplpclhshN.ttLphLtsph	...................................ppphltpsl...pslss.s.plcpslt...pLP.h...........s.....hl.p.LLphlsphhp..pp.s................clphh.ht..WlphlLphH.ushlssp...........................................p.hhstLpsLpphlppphpplp...clhshN.ttLphlht..h..........................................................	0	207	353	543
+4904	PF04615	Utp14		Utp14 protein	Bateman A, Wood V	anon	Pfam-B_5404 (release 7.4)	Family	This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA [1]. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome [1].	21.20	21.20	23.80	21.60	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.68	0.70	-13.55	0.70	-6.37	39	482	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	291	0	309	487	11	532.10	22	84.48	CHANGED	sS--...............................ps-pp.....--cchpcLhshlssLspcscp......................pp+pttsptptp.sEFsl.....sopst......KLslsDL.lsslp....ssphppstKtLsphppspp.........LcsPLsKcpQ-Rl-RpAAY-popcpls+WpssVppNRcAEpLhFPL....t..sstssshsphhsshpPpT-LEpcltslLpcSsLs.............s-cphsphE.-lphpchohEEh+tRRsELp+hRpLhaRcEtKAKRlKKIKSKsY++lc+Kc+t+...pp.pptLhcsss-tuc--hpch-cpRApERMoLKHKssSKWAKshhp.GhuphDp-sRpuhpE.LppsccLp..cKlpupp.sctspc..ssps.p-s.-cp........t.ps.pththppchpchtt.t..t............stlhshpFMpsuEscc.+cpscpEhctLp......cEhct.-stppc.t.................tppp.GRRpau.....ttpt.sppttppsppphcpthts-cppt.tsc.ptphppt.s........................tpspptpptpcppssscpNsahppspppspssppptpp.................tp.s.t.tpht.t...........ppcpKpppsstschhhspsp.............................sppp---tp.s..........hcpp-lIpc......AFAGDDVV.t-FppEKpcslcc-ssK.-lDhTLPGWGsWuGsGlppp...p..p...++hltKsctl.phcpRKDppLppVIINEK.ps.KKss+a.sspLPaPFco+pQYERSlRhPlG.-WsocpoaQchT+PRVlsKtG.lIcPhctPh	...............................................................................................................tp...................................................................................th.t........h................................................................................................tl.ltph.h..ht..........t...t.....t.hp....h....t..t.ttt....................................lt.h..PL.p........pc.hpRthsht.spp.ht.p.W..hl.........ttc..........putp.l.Fs..................................................h....t..s..ts.hptpl...thh.tst........................................t..c......hthtt...hs..cEhh....+ptc...hthhRtl.....h.ph+u+R.pKIKSKta++lh++t.c.+.............................................pth.......t..ss.........t..s.p.h...t.-htRh.ERhsh+Hp..p....upWA+ph.....hst..c.p.sRttht-...h...thtccLp..p+h..................t.tpt....p.........t..............................................t...h.tt.tt.................................................tt..t..hhpts.ttt.....tt..t.t.t.h......................pp.pt....pt..tt..............................................p.tcp.....t..................t..........t...t..p....tt..............t.......................t.....................................................................................tt..........t..........tt.h.ttt........t...............................................................................ttptp....t...t..p.....t.t...............................................................tt.ptp.t......................................pppthltp......AF.....s...s.D..-l..t-F.p-Ktp...pt....pts...........p.......h.....s.........s..L.PGW.Gp.WsG.s....hp.p......................p+.hh+h..............R+Dtph.pVII.s.E....c..hs..h...............p...tth.sp.lPaPap.p.t.paEtshphPlG.passttshpthhtPpl............hh+.G.lItPhp...................................................................................................................	0	127	183	260
+4905	PF03851	UvdE		UV-endonuclease UvdE	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.10	20.10	20.30	20.20	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.82	0.70	-5.38	6	508	2012-10-03 05:58:16	2003-04-07 12:59:11	9	6	393	5	182	475	377	265.00	34	70.05	CHANGED	hGYVshshtLtsspPshThotTphhphtccEt.............................cpLhclspsNl+shl+hLcaNhuasIphaRLSSslhPhAoHP..chGachhshhsppLpElGclss-ashRlohHPsQFTllsSs+ccVscsAlpDhsYHh+lLcuhtls-p....ulllIHlGGtatsKcssl-cF+cNhtcLPpslKpRlsLENDD+oYTsp-lLslCEchsIPhVhDaHHHsls.....hccssL-.sh.....RIhpTWp+pslp.KlHlSsPtsspshps+p-hhcuchlhsF.pph	..................................................................hGYss..hs..hhL.hs.s.sP...s.tho.hsp.htph.t.cp.c.t.............................c+LpclsppNLcshl+lL+aNhs.a..s..IphaRlS.S.pllPLAoHs........ht...a.....sa.....h.....t...........h...p...pthpclG....ch...spchshRlohHPs........QF.slL.sSsc.c.l..hpsulp-LpYHtchLc.shG.lspp.....shhslHlGGs.Y.G.s...Kctul....-R.FhcNa.p.p.L.....s.p.....pI...+c......plsL...EN.....DD...p..o......a...o.....hc-sL...lscc...h......s..I.PhVaDhHHHhhs..........................pcps.hc.hh...........plhp...TW.........p...........p..........p.sls...s.KhHhSsP+st..t...t.psHschhc.phhhsh...h..............................................................................................	0	65	119	156
+4906	PF00580	UvrD-helicase		UvrD/REP helicase N-terminal domain	Bateman A	anon	MRC-LMB Genome group.	Domain	The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.06	0.70	-5.13	36	18162	2012-10-05 12:31:08	2003-04-07 12:59:11	16	135	4762	24	4265	16492	6532	265.50	23	35.17	CHANGED	LNspQppAlpt...hpushLllAGAGoGKT+llspRlsaLlpppt..lsPpp........ILslTFTNKAApEM+cRltp...................hltpt.........................hcthhluTFHohshclL+pphppls.......................hppsFplhDppD..................................phtllcclh......pt.hshstchhp............................................................................................................................................................thpthlsphKsphhpspphtp.................ts.htp.htphappYppphpppsh........................................................................................lDFsDLlhhshp..................................lhpp.............spplhpphpp+a+alLVDEaQDTNthQYpll+hLsspptp...........lhlVGDsDQSIYuaRGAclpNllphpc-as	..............................................................................................................................................................................................................................................Q.t.s..h.............tt.....s....h.....l..l...Au...........A.GoGKT.t...s.l...s...t....+........h....h.h.l...l..............tt.............h.t..s....t.p..........................................ll.slTFTp....t..AAt..E..h.c...pR...ltp..............................................................................................................hh.......................................................................................t.....t...h.hl......t....T.h.....H...u..h...s......p..h....l...p...t........h.......h.s............................................................................................................................h....t..h.p..h...pttp.....................................................................................................................t.h..h..t....thht...............................................t......h............................................................................................................................................................................................................................................................................................................................................h...........h....h...p...t........p.....p...t...h..h..............t.h...t...............................................................t..............t...h...h...t....t....h......h.....p....t......a....p....p....t....h....p....t....t..s..h....................................................................................................................................................................................................................lD.F..s..D...l...l..h.h.s..h..p.......................................................................................hh.pp........................................t.l..h...t...t.h..p...p...p....a...p.hlhl.DEa.QD.o.s...h.Q.h.t.....l....l.....p.....h....l...h.....t...t...t...tp............................................lh..h..V.GDscQuIY...s....a...RGA.p..p...h.t.h.pp...................................................................................................................................................................................................................................................................................................................................................................................................	0	1443	2832	3657
+4907	PF02614	UxaC		Glucuronate isomerase	Bashton M, Bateman A, Eberhardt R	anon	COG1904	Domain	This is a family of Glucuronate isomerases also known as D-glucuronate  isomerase, uronic isomerase, uronate isomerase, or uronic acid isomerase, EC:5.3.1.12.  This enzyme catalyses the reactions: D-glucuronate <=>  D-fructuronate and D-galacturonate <=> D-tagaturonate.  It is not however  clear where the experimental evidence for this functional assignment came from and thus this family has no literature reference.	25.00	25.00	25.70	25.50	22.20	20.60	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.57	0.70	-5.87	42	1495	2012-10-03 00:45:34	2003-04-07 12:59:11	9	6	1344	79	293	1024	317	436.20	44	97.60	CHANGED	Mp.hhsc.sFLLs.scs...AcpLa+chApshPIhDYHsHLsPp-Ih-s+hapsls-lWLh....GDHYKWRhMRtsGlsEphlTG.susshEKFhAaAcTl.hshuNPlYcWoHLEL+R............hF...Glst.hlspcsAspIWcpsNthLt.s....sshpscplhppuNVchlsTTDDPhDsLchHptls.t.....cpsh..hpVhPuaRPDcslplct.psassalcpLutssshplpshsshhpALcpRhcaFcphGschuDHuls.phhasc.ss..phpthhtph.hssp.hottp.tpapohlhhhLsphhpcpuashQlHlGuhRssNsthhppLGsDsGhDSlsc.s..spsLppLLsphsppstlPKhllYsLNPp.sshhluohhssFp..tt.h..plQhGuuWW.....FsDs.tsGMhcQhpphup.uLhosFlGMLTDSRSFLSY.sRHEYFRRlLCsllGchlE....pGphPs-tphlschVcDIsasNuccaF	..........................................................Mt..Fhs-.sFLLp.s-hA+cLYHcaAcc.PIhDaHCHLsPppIA-.s.hpFcNlsclWLt.............GDHYKWRhM.......Ros.......G.......V..........s..........E.....c.....h.....h........T.....G.......-..........u.....o.....D....hE....K.......FpA.W...ApTl....P...pslGNPL.YHWo.HLEL.+R...............sF.....GIst....lLuspoA-cIasp.sN-h.Ls.p....ssFosRu.lhpp.hNVchluTT..DD.PlDsL-aHtplut.........Dsuas...h+VlPoaRPDKu.hs.....I.-t.ssFsca.l.t.+Luclus.s.s.Ip...passhhp.ALpcRh-aF.st.p.G.C+.sSDHul-...slhasp.......s.........s........-s..clcuIhs+t..luG.p.s..l.......opc.Ehs.pF+oslLlhLut..YtccGWV.Q.hHhGAlRNNNt.chFchLGsDsGaDSIsDps..huptLs+LLsphspps.LPKTILYsLNPp.DNcsluohhGsFQ......stuh.....s.GKlQaGouWW.....FNDp.+-GMpR......QhppLu.phGL....LSpFVGMLTDSRSFLSY.sRHEYFR.RILCphlGchVp....sGEhPs.D..sh..L.uchVpsIsasNAppYF.........................................	0	103	204	246
+4908	PF03786	UxuA		D-mannonate dehydratase (UxuA)	Finn RD	anon	COG1312	Family	UxuA (this family) and UxuB are required for hexuronate degradation.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.21	0.70	-5.89	10	1615	2012-10-03 05:58:16	2003-04-07 12:59:11	8	7	1348	10	330	1058	320	354.40	48	97.28	CHANGED	MchsaRWaGstsDsVoLpcl+Ql.GVcGVVuALacIPs.......G-lWshEcIhchKcpIEsuGLslsVlESVPVHE-IKlGsssR-+YIENYKpTIRNLAcsGI+VlCYNFMPVhDWoRTDLphcLsDGSpALtF-cpclsshsPp..lh+p.sustsas.............................LPGhE.ph.Lsph+phhptY+cIDpEcLa-NLuYFLccIIPVAEEsGVKMAIHPDDPPaP.IaGLPRIVost-shc+llchsDSPsNGIThCoGShGspssNDls-MI+cFuc..RIaFuHlRNlKtp..sscsFhEouHhs..GulDMhslhKAhh-psacG..........hhRPDHG+plaG-p....spPGYuLhsRhhGluYlpGLa-Alpp	....................................Mc.TaR.WYGs.....sDPVoLpclRQh..G.soG.lVoAL.H.c.IPs.........................G.E..l.W..sh-EIhchKthl......E.......s...........s......G......L.pasV.........VE....S..V.P..l..H..E....-....IKtt.s....s....s.h-paItNYppTLRNLApsGIcsVC...YN..F..M..P.V.hDWTRTDLpa...h.sDGS.puLtFDphp..hs.....uh.-hp...ll..c.p...s.u.p.s-as..................................................LPGhE...pth...tL.......sph+ph..L.....thYc..sIscscLR-NhtaFLcsIlPVAEE...sGl+MAlHPDDPPhs...I..hGL.PR.Iloo..h..-Dh.phhlc.s.V..sS..uNGh.ThCTGSh....G...s...c...s..-N........D...L.ss.hl+p.FGs...RIaFsHlRss......p......t....p.............s........s....p....sFaEuuHLs.......GslDMapllKA....ll....-.p.p.act..........shRPDHG..+ph.hsDh..............tspP.GY....uhhuRhhGLu.lpGl..Alp.t................................	0	117	222	269
+4909	PF03223	V-ATPase_C		V-ATPase subunit C	Mifsud W	anon	Pfam-B_2945 (release 6.5)	Family	\N	23.10	23.10	23.90	29.00	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.06	0.70	-5.54	33	459	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	321	1	294	434	5	354.10	38	95.30	CHANGED	ahllShPsptsstps.....hpph.hhs.thtsshssstcFslP.-hKlGT.................LDsLlshSD-LsKlDstlEuslpKltphlt-l...psppspltpshhssst................................................................................................................................................................................................................................................................................................................................................................................................................................................................slssYlpp....FpW...spuKYshcp.slppll...-hluppssplDsDl+s+hssYNssKusLpshpRKp...........................oGsLts+sLs-lV+t.....-cFl..cSEY..LsTlLVsVPKs.hp-a.psYEoLoch..............................VVP+Suphls.....pDsEasLasVsLF........................KKsh--FpppsRE+.KalVR.-FsYsEcthppt+pEhschtscccp.h............................................ssLlRhh+ssaS-sFhuWlHlKALRVFVESVLRYGLPssFtuhllpsst...Kst.c+l+phLtphasaLss....suhststcsc..hs.suL...........hsppEYaPYV	...........................................................................ahLlShPsptpstps.......hpp.hpthp...thp.ss..hu.sshcFsIP.-h.K..lGT...................LDsLlshSD-LuKl.DshsEu.....llpKlsphltcl..h.-.ss..........psplpp..phhsN...s...h................................................................................................................................................................................................................................................................................................................................................................................................................................................................slspY.l.p.p....FpW...shuKYsh..c.p.sLppls.................-hlscp.....lspIDsDlKs+hstYN.slKssL.ps.l.pRKp...........................s..G..sLhsRsLs-lVc..................-c...h....V...-SEYLh..TlLV.lVPKtshp..-W.psYEoLssh.......................................VVPRSophls..........cDs-.hsLasVTLF............................+Kss--Fpp+AREp.KFh.lR.-FpYs.Ect....hcpp+cEhs+lts-c+c.h...................................................u..LlRhh+ssaS.....EsFhuWlHl.KAL.RVFVESVL....RYG....LPs..sFtuhllpssp.......................Ks....++l+phLpphataLsu....suhst..hps.....t.....hp.sul.............hspp-YhPaV.............................	0	99	156	232
+4910	PF03179	V-ATPase_G		Vacuolar (H+)-ATPase G subunit	Mifsud W	anon	Pfam-B_1274 (release 6.5)	Family	This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialised cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.	22.90	22.90	23.00	22.90	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.38	0.72	-3.74	34	591	2012-10-02 21:03:42	2003-04-07 12:59:11	10	9	372	2	345	587	15	99.90	33	78.74	CHANGED	upssGIQpLLpAE+cApchVscARct+scRLKQAKpEApcEI-pYRtp+Ep-F+chcspphGs..pssstpcl-p-TppcIpplppssppp+cpVlphLLphVhsl+	........................pppGIQpLLpAE+cAtchVsc.A..Rc...........p......+s......cR.......LKQ.AKcEA.....ptEI.-p..YRtp+EcE.Fc.p.hps.pt..........hGu.......ptshspcl-.p-Tptcl..pplppthppp...pcpVlptLlphVhsl.....................................	0	105	184	265
+4911	PF03224	V-ATPase_H_N	V-ATPase_H; 	V-ATPase subunit H	Mifsud W	anon	Pfam-B_2481 (release 6.5)	Family	The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer.  This domain corresponds to the N terminal domain of the H subunit of V-ATPase.  The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation [3].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.92	0.70	-5.31	37	456	2012-10-11 20:00:59	2003-04-07 12:59:11	9	17	312	1	294	475	12	285.20	24	62.84	CHANGED	shlsphtsplRtp.....lsWpuhhcuphlopcshphl+pl-ph..pp.+tp...hl.ppsss.thsphhl......sllppl...pcp-slpYlLsLlsD.lLsps...thtphhhshtp.tp.p....sapshLp.hhppp.Dthls.h...ushllspllstsshptsp..................chL....thhhsh..Lps...hhss................................................................................pssth...........................hslpsLptlLptcpaRthFhp..scslphLhs.lL...................................................................................sspsslQL.YpsllslWlLSFpsphstphhppp..ll.hLscll+pos..KEKlsRlsluslhNLl...spstpt.........................................hhthhl.sphlt.hlppLppR+a....sD--lh-DlphLp-hL	............................................................................................................................................................................................................................................................ht..ttplhtp.lsWpshhput..hlotpphphlpth-ph.ptp..+tp.........hl..pppss..ths.phhl........slhpph.........p+ppslpYlLshls-..hLpps.....ptsphhhp.tt.tp.t..............at.hL.t...hh.s..pt..-.hh..h......uupllsplhshstp..pt..........................psL....phhhsh..lps.......h.p.s...........................................................................................................................ss.sth..............................phsh.psLphh.L.+hpp.hR.hahp...........ssslp.slhs...lL...........................................................................................................................sspsshQl.YphlhslWhLoFpsthst.p.h..p.t..................ll.hlscllptss...KE.KlsRlhlushpNhl..ppstt..........................................hh..h.l.....spl.t..lp.Lpt.p.+.a....sDtDl.cDlp.L.-hL...........................................................................................................................	0	106	168	246
+4912	PF01639	v110		Viral family 110	Bateman A	anon	Pfam-B_1518 (release 4.1)	Family	This family of viral proteins is known as the 110 family [1]. The function of members of this family is unknown. The family contains a central cysteine rich region with eight conserved cysteines. Some members of the family contains two copies of the cysteine rich region Swiss:P18560. 	25.00	25.00	48.20	48.00	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-11.11	0.72	-4.49	10	107	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	11	0	0	103	0	107.00	40	82.88	CHANGED	llsLLup......hsssptsspL.pTpsPPccELcYWCTYscsCcFCWDCQcGICKNKlhss..ssIhcN-.YlpsChVoRahsp..ChY-lst+I..hHsMsCSpP+sas.saclh	...............h.hhLLu.......hh.ththtpL.tTppPPccELpYWCTYscpCcFCW-CpcGICKNKlhcs.h.shIhcNc.altsCpVoRh...sp..ChY.hss.+h..hH.M-CSpPpsap................	0	0	0	0
+4913	PF03402	V1R		Vomeronasal organ pheromone receptor family, V1R	Mifsud W	anon	Pfam-B_3057 (release 6.6)	Family	This family represents one of two known vomeronasal organ receptor families, the V1R family (after [4]).	25.00	25.00	25.00	25.00	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.93	0.70	-4.99	2	2399	2012-10-03 04:04:29	2003-04-07 12:59:11	9	5	78	0	1464	2009	0	245.10	33	86.01	CHANGED	KLlstp+s+.hDL.IuhLSLhpLhhLlhhuhIAsDhFhsWttWsshhCpSLlYLaRhhRGLuLssoCLLsVL.sIhLSsRSSCLsKFKHKssHHISsAhL.h.VLYM.hSSHlLVSIIsTPNLTopDFhaVTQ.CSlLPMSY.hpShFSTLhAIR-sFLISLMsLSohYMVALLhRH+KQspHLpuTSLSsKASPEQRATRoIhhLhSLFVlh.lh-plVhpSRhhahsssl.Y.hplhMsH.YATVSPFVFIsTEKHIlp.hcS	..........................................................h......p.pshD..l.Il.tHLsl..sNh.l....hLL..o.p.G...l......t..s.....h..h..h..s..h..p.........h...s.....-.h.s.C.K.h.lh.Yl.hRVu.R.GLulC...oTCLL.SlFQAlTI.S.P..ss.S.p.hup.l.K.s.+.h.s..+....h...l...h...s.s.hh.h...h.W.l...l..s....h.h...ls....h.....s..h..h..h...h..h...h...u...s...p....N....s.....o....s..s....s.....h.....h..h..s..h...p.....a..C.s..h....h...s...h....s....t..h....h..p......h..l..h..s...s..h.....h.s.h....+....DlhF.l.u.LM.shu.S..GYMVh.l.L.aRH+..+p.VpH...l..Hss.s.hSs..+..ssPE.sRAs+oll.hL.V.s.haV...hhY.s..h.s...s...l...h..h......h....h..h........h..p..p...p..s...h..h..h..p....h..p..h..h.....h.s.......s.a.sslsPhl.hl........................t..............................................	0	7	20	850
+4914	PF02830	V4R		V4R domain	Bateman A	anon	[1]	Family	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons [1].	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.03	0.72	-4.13	52	616	2012-10-02 19:02:47	2003-04-07 12:59:11	13	22	405	2	314	617	58	62.00	25	18.38	CHANGED	hhhph-sshpttshstsscPlCahhtGhhsGhhs........phhs+p..lhhcEspCtupGss...pCpahsc.	......................phcss.hht.th.st..ss...cP.lC..a.hhsGhhsGhhs.........shhu...pp...lhspEs..pCt.ut.Gcs...pCpFhsp........	0	95	201	264
+4915	PF01496	V_ATPase_I	V_ATPase_sub_a; 	V-type ATPase 116kDa subunit family  	Bashton M, Bateman A	anon	Pfam-B_446 (release 4.0)	Family	This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i.  The V-type ATPases family are proton pumps that acidify intracellular compartments  in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes [1].  The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices  it has a hydrophilic amino terminal and a hydrophobic carboxy  terminal [1,2]. It has roles in proton transport and assembly of the V-type ATPase complex [1,2].  This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [2].	26.50	26.50	26.60	26.60	26.30	26.40	hmmbuild  -o /dev/null HMM SEED	759	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-13.24	0.70	-6.68	16	3017	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	1209	4	1136	2604	291	408.80	17	89.37	CHANGED	lstLt-lGlVphcDLNpcls.shQRchlp-h+Rts-h-+pLthlppplp+ttl.h...........ptthp.sh...p.........ph.chptphpclEscl+plpcshcpLccphppLpEhtphLcpspphhcpt......................cthp............htsl.hs.pthp.......tsphlcl....................hluGslspc+hsshcchLh+ss+G..hht.hplcpsh.-sp......hpsallhhpucphtp+lc+Is-shthphashs-pptt.p-hlpplppclp-lpphLcpspsplcphlsthtcplhsapphlpp-Kslacshshhshss..+slIhEuWsPtc-lsplppsLccssstsu...lsslhs.hcsp-pPPThh+ssKFspsFQsIs-sYG.lspYcElsPuhhhhlTFPFhFulMhGDhGaGllhhLhALhllhtcpphsstp.........aph+YIlllhGlFSlhhGhlYN-hFucshslFtSthths.......................hpt.sl....t.s......YPhulDshapsss..tl...s.hhhthSlllGllHhsaGlhluhhNthph+...p.hslhtshlspllalhsIhGhh.h.hh.ta.h..h...............sPslL.hhl.MFLhs....s........................lQshLlhhulhslPllllhtPlhlhtpthp...........................t.............................h...hG...h.htpsIasIEh..sLGsluphsSYlRLaALuLApupLSsVl.sMshthsh.hts......slhhhllhshhhllshsl.llMpuLSAhLHuLRLHaVEFhuKF.YpGsGhpFpPFuhp	.........................................................................................................................................................................................................................h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.ha..............h...h............................................................................................................................................................................Ph..t..........ht...hht...h...st..ths......s..h....a..h...............hauhhhsDhu.uh...h.h..h.h.s...h.h.........h......................................................................................................h.h.........sh.shhh.G.hh.h.s.thhu...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.t.hSa.Rlhs..h....hst.................h...h.........................................................hh....h....h.hhht.h...shlps.RL..............h....................hE..t...............t........................................................................................................................................................	0	428	699	955
+4916	PF02346	Vac_Fusion		Chordopoxvirus fusion protein	Bashton M, Bateman A	anon	Pfam-B_822 (release 5.2)	Family	This is a family of viral fusion proteins from the chordopoxviruses. Swiss:P26312 a 14-kDa Vaccinia Virus protein  has been demonstrated to function as a viral fusion protein mediating  cell fusion at endosmomal (low) pH [1].	22.00	22.00	22.00	22.20	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.81	0.72	-4.54	11	335	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	61	0	0	153	1	42.00	54	24.57	CHANGED	.plcslEcRLssLpcpapplhcsC+psscslcRLENHhETLR+uMlsLsKKIDVQTG	.......................QRLTNLEKKITNVTTKFEQIEKCCKRNDEV...............................	0	0	0	0
+4917	PF02691	VacA		Vacuolating cyotoxin	Bashton M, Bateman A	anon	Pfam-B_436 (release 5.5)	Family	This family consists of Vacuolating cyotoxin proteins form Proteobacteria. These proteins are an important virulence determinate in H. pylori and induce cytoplasmic vacuolation in a variety of mammalian cell lines [1].	18.90	18.90	19.30	19.10	17.70	17.70	hmmbuild  -o /dev/null HMM SEED	981	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.36	0.70	-13.81	0.70	-6.90	2	1164	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	43	1	2	1174	1	244.10	38	85.28	CHANGED	AFFTTVIIPAIVGGIATGsAVGTVSGLLuWGLKQAEpANKsPDKPDKVWRIQAG+GFspFPpKpYDLYKSLLSSKIDGGWDWGNAApHYWlKsGQWNKLEVDMpsAVGTYpLSGLhNFTGGDLDVNMQKATLRLGQFNGNSFTSaKDuAsRTTRVsFsAKNILIDNFlEINNRVGSGAGRKASSTVLTLpuSEtITSpcNAEISLYDGATLNLsS..N.SVcL.GpVWMGRLQYVGAYLAPSYSTIsTSKVpGEhNFpHLsVGDpNAAQAGIIAspKTpIGTLDLWQSAGLsIIsPPEGGYcsKspssP.............QN.......NP.NssQKTElQPTQVIDGPFAGGKDTVVNI.+lNTKADGTl+sGGFKASLoTNAAHLpIGcGGVNLSNQASGRTLLVENLTGNITV-GsLRVNNQVGGhAlAGSSANFEFKAG.DTpNuTATFNNDIpLG+hVNL+VDAHTANFpG.I.hG.......NG...............GhN..TLDFSGVTsKVNINKLhTAuTNVslKNFsIpELlVpTps.ShGpYThFuEsIGspSRIssVpLpTGhpshaSGGVpFKuGcKLVIDEhYauPWNYFDARNlpsVEIs++hh.usPtN.hGpotLMFNNLTLspNAsMDYup..sLTIQGcFhNNQGThNhhVpsG+VATLNsGptAuMhFNN.lDSsTGFYKPLIKINsAQsLhKNpEHVLlKA+.IsYs.Vus.Gss....uhSNsNLpEQFKERLALYNNNNRMDTCVVR..NhsDIKACGMAIGNQSMVNNP-NYKYL.GKAWKNhGIsKTANsopIuV..LG.NSTPTpssssTTNLPTNTTNNARFASYALIKNAPFAHSATPNLVAINQHDFGTIESVFELANRSpDIDTLYANSGAQGRDLLQTLLIDSHDAGYARTMIDATSANEITpQLNsATTTLNNIASLEHKTSuLQTLSLSNAMILNSRLVNLSR+HTNpIDSFAKRLQALKDQRFA	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1	2	2
+4918	PF03077	VacA2	VACA; 	Putative vacuolating cytotoxin	Griffiths-Jones SR	anon	Pfam-B_2866 (release 6.4)	Family	This family contains a number of Helicobacter outer membrane proteins with multiple copies of this small conserved region.	19.50	19.50	20.00	35.50	17.70	18.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.89	0.72	-4.38	10	460	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	51	\N	19	481	0	59.90	41	7.82	CHANGED	uhlGYIsGsFcAppI.YITGsltSGNuhuo..GGGAsLsFsuusslslssAslssppsssppS	....hlGYIsGsFpAppI.YITGsltSGNuhso..GGGAslsFsussslslssAshssppsss..S...	1	11	16	19
+4919	PF04333	VacJ		VacJ like lipoprotein	Kerrison ND	anon	COG2853	Family	VacJ is required for the intercellular spreading of Shigella flexneri. It is attached to the outer membrane by a lipid anchor [1].	25.00	25.00	34.90	34.60	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.37	0.71	-4.86	10	1871	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1652	0	385	1266	1805	200.70	39	75.89	CHANGED	sstsppDPLEuFNRshasFN.sslDpall+PlApGYpphVPcsV+sGlsNFhsNLsEPsohlNpLLQGcscpAhpshsRFhlNTThGlGGLlDlAotsG..Lpppscc.FGpTLG+YGVusGPYlhLPlhGPsTlRDssGsllDth..hPhhhhlss......shuhs+hulpsl-sRAphLss..-sLlcsS.DPYlhhRsAYhQp+pa+lp	......s...thsDPhEuaNRsM.asFN.ssLD...Yll+PVAh.uYp..shsPpPsRsG..........lsNFhsNL.p-PsshlNslLQGcstpuhtchsRFhlNT.hhGhGGlhDVA....uh.s.s......Lp+....pcpc..FGpTLGaaGV....ut....GPYlhLPhhGPtTlRDss...GphsDs...h.......P...h...h......h...hsh...................sh.u.h..u...t.....h...s...l.....ps.......l-...sRA.....pL.L.ss......Ds.L.h.c.s..u.s.DPYhhl..R-AYhQ++ch.h.t..................................................................	0	94	207	299
+4920	PF04294	VanW		VanW like protein	Kerrison ND, Finn RD	anon	COG2720	Family	Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin  resistance gene clusters vanB [1] and vanG [2].  The function of VanW is  unknown.	21.70	21.70	22.20	23.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.95	104	1141	2009-01-15 18:05:59	2003-04-07 12:59:11	8	16	702	0	306	1013	69	131.50	36	30.04	CHANGED	tsRspNlplAuptlsGsllhPGE........sFSFNphlG.potpp.GYppu.l...l.hsu.....chss....ul.GGGlCQlSoTLasAshhAsLpllERpsHSh.lsYs......Ph....G.....pDATlsas....h.lDh+F+NsostslhIcs....ths.ssp...lssplau	......................................s.sRspNlpluApplsGslltPGE........sFSFNphlG..p.o.tpp.GYp..puhl...l.h.sG.......chsp............uh.GGGlCQ.....lSoTLYsAs..ht.A....s..L...pl..lERpsHShslsYs..........Ph..........G.....pDATlshs.....h..lDl+F+Nssstslhlps......hhs..ssp..lsspla...............	0	143	249	290
+4921	PF02557	VanY		D-alanyl-D-alanine carboxypeptidase	Bashton M, Bateman A	anon	COGs	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.72	0.71	-4.31	63	2350	2012-10-02 01:02:30	2003-04-07 12:59:11	12	58	1623	4	473	2508	550	132.00	31	49.45	CHANGED	shhlcpcsupuhpph.hpAApcc..Gl....pLh...........h.hSGaRShppQptla..pt.sp..................tpstptstphsA.PGtSEHptGhAlDlussp........h........ptshtpsttscW..............................LpcsAtca.GFhlp..............a.Ppsppp.pGlsYEP...W.......HhRY.lGh	........................................................t...lptpstpshpph...hpA.A....pp...p.....Gh.....plt...............h..sSGa......RSac.pQpp..la.....pthhp................................................ppuppt.stp....h...uA.hP..G.....t.....S.....E..........Hp.....s.....GLAhDlss...s.s..............................................pttht.p.sttspW.......................................................................L..t...c.pA......t...c...a...G.FllR.........................Y..psc...p..p...T.GhtaEP.......WHhRYlG.................................................................................................................	0	157	322	407
+4922	PF04892	VanZ		VanZ like family 	Finn RD	anon	Pfam-B_5529 (release 7.6)	Family	This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases [1].	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.73	0.71	-4.21	19	3861	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	2101	0	830	2978	740	136.10	18	66.89	CHANGED	halhallhlhhhhhFt..h...hh............tshshsLhPhtt...........................shhphhhsllhahPhGhllshhhtphp.....shhpslshuh...hhu...LhhEshQhhhsht.......ssDIsDllhNTlGuhlG.hh....lhhhht+hh.+t	.............................................................................................................................hh.h.......................................................hp..h......h.......................................................................hh.h.p..h.hhN..lh....ha....h...P...L.....G..h.....h.....h..h...h....h.h...t..p.ht....................................shh.t..s..l....h...h..u....h......hhu........l.....h...h.EhhQ.h.h.......h.s.ht.............ss-lsDl..hh.N....ol....Guh..l..G.hh.......lhh.hh.......t...........................	0	303	585	720
+4924	PF03490	Varsurf_PPLC		Variant-surface-glycoprotein phospholipase C	Griffiths-Jones SR	anon	PRODOM	Family	\N	20.70	20.70	20.70	21.50	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.66	0.72	-4.29	2	23	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	14	0	5	24	0	46.70	48	14.12	CHANGED	FssstWpPQSWMpDhRS.ItchsIsQVhhVGuHsAuoaGlph.SPFGhDAP	.......thtWpPQSWMcDLRS.It-huIsQlslsGoHNuuoYGIpptSPhuhDA......	0	3	4	5
+4925	PF01992	vATP-synt_AC39		ATP synthase (C/AC39) subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the AC39 subunit from vacuolar ATP synthase Swiss:P32366 [1], and the C subunit from archaebacterial ATP synthase [2].  The family also includes subunit C from the Sodium transporting ATP synthase from Enterococcus hirae Swiss:P43456 [3].	22.20	22.20	22.20	22.60	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.84	0.70	-5.32	10	1321	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	1055	5	489	1086	162	301.60	22	94.11	CHANGED	YlsARlRuh+u+LLs-pcascLlcscohEph+hhLEs.s-Yushlsslssh..ssptlE+ALppsLAcpachlhclusupl+phlchhLc+aDlcNIpsLI+uKhsstssEEllshhhPhG...sacphptls-usolEEll.ssLcGT.YtcsLpchLu..-h-.pshtlh.ptLhKtYat-hLchsh.....hpuc-pclhcEalchElDh+NlpshLRuKu.sGLosD-lp..lhlpGGpLtc.tLctLtpu-sh-tllutLEGTpYupslp-stpphtts............lpslEcsLcchllchhschuhhpPloVuslluYllpKEpEl+NL+sIA+sttpslcsEcIcc.ll	..........................................................................................................hpshlRshcstl.Lspppapplh.ps...c.s.h.-...............s.h.t.h.hL.ps....osYtt.h.l..sp......t......t...p.th-ttlpppLh.pp.a.phhhp....u..s.t.....tphlp.hhthpa..hcNlt....lllp....up.h....p..t..p....s..h.p..c.......l.h.........h...............s.........h..G...........h.....p.....p.....h.....t....t...l....h....h....s...p.s.....p....-lh...thl..h...........t..s.....h.....tt......hhp...phh........s..........p.............h....-.............p.......h.......s.l.p.h.l.h.s.h.l.h.c.........t..a.h.t..p..h.h.chsp...........t.s.tp..t-...lhpphl.t..hph...Dh.......pslhhhlpu.....ht....p.....ph....s...t.....s...t......ht..plh.sp.tG.p..l..s.c...t.h.h.tls.p..s.p..s..h-.phhsh...l...p...h..s....h.p..hl.hp.s.h.tt..t.................................pslE...c.h.hhpt..h.p..h.t.p.....uhh.tth...s.h...t..s..hh.ualhh+E.El+NlphIhpshtp.p.ht..ppIpphh.h.....................................................................................................................................................	0	184	295	405
+4926	PF01991	vATP-synt_E		ATP synthase (E/31 kDa) subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the vacuolar ATP synthase E subunit [1], as well as the archaebacterial ATP synthase E subunit [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.23	0.71	-5.04	17	1053	2012-10-02 21:03:42	2003-04-07 12:59:11	13	6	818	14	504	1038	112	184.00	22	89.44	CHANGED	hIppEAc-KAp-IpscA--Ehsh.Kschhcppctplcphhc+tcKQs-hp+phthSshh.puRh+lLps+--llpslhcpscccLtplsc-p..tYpphLcsLlhpulhcLt.EsplllpsRccDhpLlcsh.lsphtpchctpht.ps..hhs-s........................c.shGGVlltstcG+IclsNTl-uRL-hhhpphlspIpctLF	...................................................................I.p-ApccAp.cI.t...cAccEhph..htc.hh....pp..t....p..t...p..h...pp...h...hc...+..tc.+.p.s...........c..h..pp..p....h....p....h....Ssh.t........p.s....Rh.....c...lLp.s..+.p-lls........clhp.c....u...........pcc.L.t.p.l..........s......p.........s..........p.....................t...........Y.p.phLpsL..lh..pu....h....h....p.......lt.....c...s..p.h......h......l.h..s.pp...pDhp...l...l.c.ph..h..th..tt......htt......th......t............t.................h.....h.....s-p......................................p.ht.G..GlhlhstsupIplssTh-shlchhh.pphhspltthLF..............................................................................	0	194	321	422
+4927	PF01505	Vault		Major Vault Protein repeat	Bateman A	anon	Bateman A	Repeat	The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function [1]. This family corresponds to a repeat found in the amino terminal half of the major vault protein.	20.00	8.30	22.70	8.50	19.30	8.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-7.95	0.72	-3.90	85	662	2009-01-15 18:05:59	2003-04-07 12:59:11	13	12	77	227	332	619	5	43.50	31	23.60	CHANGED	hhVLspspALtlcAhpsa....pD.tp.....s....................RhsG-cWllpu..P..tsYlPs	....................hllspspALpL+Alpsa.........pD..tp.......uhp..............................Rh..sG-cWLlpu...s......tsYlP.....................	1	173	214	257
+4928	PF01847	VHL		von Hippel-Lindau disease tumour suppressor protein	Bateman A	anon	Swiss-Prot	Domain	VHL forms a ternary complex with the elonginB  Swiss:O44226 and elonginC Swiss:O13292 proteins. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor Swiss:P15692 mRNA.	20.00	20.00	20.10	20.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.67	2	136	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	97	14	79	139	2	121.10	33	56.67	CHANGED	RPRPVLRSVNSREPSQVIFCNRSPRVVLPlWLNFDGEPQPYPhLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDaPsVpKDlpRLoQE+ltpQ+ht-	..........................pS.tst..s.Vh.FsNp.osRsV..shWlsapGc..p.Y.ss..LtPGpth...clpTYhsH.WlFR..Ds.h..Tt..-..th.hV.pp..pc.............lahP.........................t.............t.....t............................s...............IphP..hh....oL+c....s.h..h.l.t...hh.t.....t..............................................................................................................	0	25	39	61
+4929	PF02209	VHP		Villin headpiece domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	21.70	21.70	23.60	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.70	0.72	-4.26	15	900	2009-01-15 18:05:59	2003-04-07 12:59:11	14	43	134	38	458	817	14	35.90	47	4.18	CHANGED	YLo---FpplFuMo+pEFhcLPtWKpppLKKchtLF	...aLSsE.-F.......p........plF.GMohpEFspLPhWKpspLKKcttLF...	0	137	202	310
+4930	PF04702	Vicilin_N		Vicilin N terminal region	Kerrison ND	anon	DOMO:DM04811;	Family	This region is found in plant seed storage proteins, N-terminal to the Cupin domain (Pfam:PF00190). In Macadamia integrifolia (Swiss:Q9SPL4), this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif.  These peptides exhibit antimicrobial activity in vitro [1].	26.70	26.70	28.60	28.60	26.60	25.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.99	0.71	-12.08	0.71	-4.59	4	32	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	13	0	1	40	0	123.70	35	28.90	CHANGED	sGR+s.-DDPppcYEpCpRRCc.-spGp+EQppCEcRCcpphcEcpppp....EDPQppYppCppcCpppE...R.h.pCpQpC.cpaEpp.ppp..............................pRQap-CQpRCppQEQtPccpQQC.RcCREQYpE.p.+Gcc-ph.....ctccpcoEEG	.......................thppC.p.Cp..tpt..pQppCpppCcppht.Ecpppp....................c......DPpppYcpCppcCpppc....c.p.p.CpppCpcpaEpc.ppp......................sp+pac-CQp+CppQEQtscpppQC.pcCccpYpEp.h+t.tc..pp.....tpctct-E.t.................................	0	0	0	1
+4931	PF00559	Vif		Retroviral Vif (Viral infectivity) protein	Bateman A	anon	Swiss-Prot	Family	Human immunodeficiency virus type 1 (HIV-1) Vif is required for  productive infection of T lymphocytes and macrophages. Virions  produced in the absence of Vif have abnormal core morphology and  those produced in primary T cells carry immature core proteins  and low levels of mature capsid.	25.00	25.00	28.30	28.30	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.46	0.71	-4.41	10	6238	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	93	4	0	6291	0	184.00	79	99.34	CHANGED	pEKcWlVhlTW+VPc.RIc+W+SLVKYhhYhoKcLptWpY.hHHapssas.a.TsSRllIPL.uc.uc.LcVssYWpL.TPE+GWLSoYAVuIpW...hpcpYhT-VDPssADpLIHspYFsCFo-sAIR+AIRGc+llshCpFPcGHK.QVs...SLQYLALhAl...lpp+pp+scssss+phsccptsshphA+pc.tpspppsGp	............MENRWQVMIVWQV.DRMRIRTWpSLVK.HHMYl.S.KK.AKs...WhY.RHHYESpHP.+lSSEVHIPL..G.........D....A.....+........LVIpTYWGLHT...G.....E......RDWHL.G...Q.GVSIE.W............Rp+...RYSTQ.VDPsLADQLIHLaYFDCFS.-SA....IRpA.ILG+l..V..pP..RC.E.YQAGHN........K.VG......SLQYLALsAL..................ls.P..K.K..h.....K..P...PLPSV.p..K.L.TEDR.W..NKP.QKTKGHRGSHTMNGH....................................................	0	0	0	0
+4932	PF01044	Vinculin		Vinculin family	Bateman A	anon	Pfam-B_1420 (release 3.0)	Family	\N	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	968	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.98	0.70	-13.84	0.70	-6.55	10	1199	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	103	65	681	1153	3	334.80	14	87.69	CHANGED	.h+T+TlEplLEPlspQVopLV.h+p...uphctstshcLossVAuVppAssNhlchGc-hspposD..Lcc-MssAlpcVcssuchhcpAupphpcDPhSostRsphlcuARulLSusocLLlhhDpu-V+KIlcss+tVpDhLssscsspoh-DLsshhKsluPshs+lschlscRQQELs+.pHR-.LlsuhsslKchuPlLloAhKsalcp....P..slpEAtcNRsalsccMs-tlNpI.cVLQhTo...........oshp+shuuhuscLssAL-hLccs..........hI...lDsushsptRstPp.ccclcullSssutMADu.CshcsRtp......ths..........................................................................................................AEss.............t.................................................................................................................................................sscQALpsLloEhtpsAspps......chssLsssID+.........hptcsc................DL+cplR+AlsD+VSDsFhDToTPLhlLlEAA+u.....G+EcshcE+ApsFp-HAs+LspsApLusuhu..sNccsVchlptoAsQl-sLsPQVIsAA+ILhppPsSKsApEph-shKpQWtDpV+hLTstVD-hTsscDFLssSEsHIhcDls+ChhAlps.........t-scsLsssAuuIttRusRVlhVscsEhDN.EsshaTE+VppAschLcsslsPhhs-ttplAsNstcss....sspsac-s..chlsAsRhVtDAlp..........................................................sIpculLM..pcsPs-lsssophc.....pED..sssRssssscsss......csssssEoscE..tplh.EcKsplstQhpshhtstppLcpElsKWsspGNDIIuhAK+MshlMhEMo-hsRGcG..tTppDlIssAKcIA-Auscls+LA+plAcQCsDpph+psLLthhpRIshhspQLpIhSpVKAshhshus.........Elsspsh-.usppLlpsApNLMpSVhpTV+AA.sAShKhRoc.......uusplpWhhKsPhpp	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	189	244	434
+4933	PF02236	Viral_DNA_bi	Vir_DNA_binding; 	Viral DNA-binding protein, all alpha domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_1651 (release 5.2)	Domain	This family represents a domain of the viral DNA- binding protein, a multi functional protein involved in DNA  replication and transcription control.	23.50	23.50	23.70	38.00	21.60	23.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.80	0.72	-3.82	10	131	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	98	7	0	139	0	87.80	45	18.36	CHANGED	PlVSAWp+uMElhstLhE+Y+VDsc...sh+hLP-pu..psa+KlspsaLNEc+hsl.LTFSSpKTFsslMGRFLtualpsaAGltsspas	.........PlVSuWEKGM-sMssLME+Y+VDss.+sua+LMP-Qs..ElapKlC.poWlNEE+RGlpLTFoopKoFoshMGRFLpualhuauGIuppsWE.......	0	0	0	0
+4934	PF03728	Viral_DNA_Zn_bi	Vir_DNA_Zn_bind; 	Viral DNA-binding protein, zinc binding domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_1651 (release 5.2)	Domain	This family represents the zinc binding domain of the viral DNA- binding protein, a multi functional protein involved in DNA  replication and transcription control.  Two copies of this domain  are found at the C-terminus of many members of the family.	25.00	25.00	64.00	39.20	21.80	17.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.66	0.71	-4.03	22	260	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	98	14	0	276	0	122.10	35	50.61	CHANGED	stCpshh+tsst...G.c.hChhsshhlspspsl-hssso.-suhtAhhc.P.shsh.ssN.htRssht.......hpNsDh+lss.Dlhp...shphspp.hu.sas-s.....hhsphtapp.thpappshhPpsp	.....tCss.p+s....ss.s......G..+.hChhsshhlspscsl-hDssS.-..s.u.hA..hcpP..hsh.spN.hhRNsht..................hsNsDh+hss.Dhhs...s.QhSp+.hu.hFsEs.........shsphtapp.hhtahpsshPsh............	0	0	0	0
+4935	PF00426	VP4_haemagglut	VP4;	Outer Capsid protein VP4 (Hemagglutinin)	Finn RD	anon	Pfam-B_161 (release 1.0)	Family	\N	19.80	19.80	19.80	20.70	19.40	19.60	hmmbuild  -o /dev/null HMM SEED	776	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.36	0.70	-6.57	9	3505	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	491	35	0	2781	0	337.90	67	99.90	CHANGED	MASLIYRQLLsNSYoV-LSDEIpsIGopKopNVTVNPGPFAQTsYAPVsWGsGElsDSTsVpPsLDGPY.....QPoohp.PssYWhLlsPsssGVVhEu...TssoshWhAslLlEPNVppssRpYslhGpshQlsVsNsSpo+WKFh-hhKsossusasphsoLhos.+LtuhhKps.splasYpG-oPsuspshhssss.hsslshshps-FYIIPcSQputCsEYIpNGLPPIQNTRNlVPluluSRsIh..RAQsNEDIVISKTSLWKEhQYNRDIlIRFKFuNoIIKuGGLGYKWSEISFKssNYQYoYpRDGEpVsAHTTCSVNGVN-FuYNGGSLPTDFsISRYEVIKENSYVYlDYWDDSQAFRNMVYVRSLAAN.LNsVhCoGGsYsFtLPVGsWPVMpGGAVoLphAGVTLSTQFTDFVSLNSLRFRF+LoVpEPsFoIoRTRsopLY..GLPAuNPNsspEYYEhAGRFSLISLVPSNDDYQTPIhNSVTVRQDLERQLs-LREEFNsLSQEIAhSQLIDLALLPLDMFSMFSGIKSTl-AsKSMATsVMKKFKpSpLAsSlSpLTcuLSDAASSlSRuoSlRSs.SssSsWTslSpplosssssspslSTQsSsIS++LRLKEhsTQT-G.MsFDDISAAVLKTKIDKSsplstssLP-IITEuSEKFIPsRuYRlIccDpVaEsos-G+aFAYKV-TFEElPFDl-KFA-LVTDSPVISAIIDFKTLKNLNDNYGITRcQAhNLLRSDP+VLRsFINQNNPII+NRIEQLIhQCRL	................................................................................................................................................................................psYsVsL.DEIppIGSEK...o.QNV.TlNPGPFAQTpYAPVNWGHGEINDSTTVEPlLDGPY.....QPTTFsPPsDYWILIsS...NTsG...VV.YES...TNNSDFWTAVIAVE....PHVssssRQYslF..GENKQFNVc....NsS.sKWKFlEMF+u....SuQs-FhsR...RTL.TSDT+LsGlLKYG.GRlWTFHGETP+AT..TD.u..Ss.TuN...LssloIsIHo..........EFYIIPRSQES..KCsEYINNGLPPI..Q....NTRNVVPlSLSSR.SIpYp.....RAQ.....VN.E.DIsI..SKTSLWKEMQYNRDIhI+h............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+4936	PF03225	Viral_Hsp90	Vir_Hsp90; 	Viral heat shock protein Hsp90 homologue 	Mifsud W	anon	Pfam-B_2880 (release 6.5)	Family	\N	25.00	25.00	56.60	56.60	22.90	20.10	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.68	0.70	-6.21	17	124	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	41	0	0	124	0	433.40	32	96.48	CHANGED	ssphhtchhphhatcs-hccphpchhshlhpp.tp.sp..ats..t...h.sasushhlpssplhsssssshEhhclhllahhhlp.shhc+osasscshh.sslshtpshtphc..ahshsl.......cshGCpaohpDlpp.....phss.st..hth.plaplsNShG+Llshp-lpstshhsF.plssspsssslssshssNchhhpClplacp...hssspusts+hphppchhcshlshLtspp..hpphscNP.LlhuhhhshhpphsspssuFccNhcslc.lpssahshlcclFthshphs..-scLhhs..lspspls.......pllsp.hhluphlc..pshhs.sss.ssLscclDthlsc.hl.p.ht...t.spshlhsuhLal.....aGpapTNtpRh.ppPpphphshpt......pshphphSslps..lhsplppphPch.......NlhRtWsstRuscAhtlF+shs..FpPhhasplPslhsYMpFDFaKtlshptloc-EhpshpsL+h.s...............................cs+oststpsppchcshlh	........................................................t.p..h.phhphhhtct.hpphhpp.hp.h.tp...................phtssh.hpttph..ss.ss.p..phhllh...h...th.phsshs.tshh..thp...p........hhshs........pp.GphashsD..Vcshhh....s.sss-h..sts-psasLSNSsG+LlsssElcshc...shsF....spshcs.sssssssphpsaLshCls...Lacc.....pshpssshhslhh.hasslhpsLsohs.hhcphscNP.LlsGhll-hhhc.pVahsoFcsNl-sl+hh.puphhsllhslashspspc...D-+lLhs...hsss-hsht..shlslhDshlllGs.lRpl-hhsp.ssshssLsp+lDhhlss.............sssc..Lpsshhas......a.uhapss.pRh.ppst.hph..t.......t.h.hphsslpt..hhs.lpp...ph.......shhRtahut+uphAhpla+phs..F.Ph...plPshhsah.hDFaKtls.shlotcEh.tLpplc..s...............................c..................th..........................................	0	0	0	0
+4937	PF04530	Viral_Beta_CD		Viral Beta C/D like family	Waterfield DI, Finn RD	anon	Pfam-B_4973 (release 7.5)	Family	Family of ssRNA positive-strand viral proteins.  Conserved region found in the Beta C and Beta D transcripts.	23.40	23.20	23.70	54.40	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.85	0.71	-3.95	12	26	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	16	0	0	26	0	117.70	38	71.27	CHANGED	h.Hs.sCsCspC..sspsp.hsus.p........pssss.sEpsspt.sh.sshhsppYhhllsslhll..h.hhlYlh....sssssssssYaYQDLNSVclchG..sPlDP-VItAIHHaQcaPFGpsPth	IhHS.sCsCscCphssssohsssspp.........sssosVEpTsct.hh.hsshsspYllhlsslsll....hslYhh....sss.ssshshFaQDLNuVpIchuh.sPlDPcVItAlHHWQ+hPFGcsPt...	0	0	0	0
+4938	PF00729	Viral_coat		Viral coat protein (S domain)	Bateman A, Griffiths-Jones SR	anon	Pfam-B_870 (release 2.1)	Domain	\N	23.00	23.00	24.00	24.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.15	0.71	-5.01	13	577	2012-10-04 01:49:40	2003-04-07 12:59:11	13	2	91	43	0	572	4	198.00	26	66.94	CHANGED	psGuIhA..PVAhuph.lpsppP+hp.pspG....SsploHpEllsslssoou..hphsss.ss.t.phplNPhNsulFsWLsslAsNa-pYpFsSlplpYlPhCsoTosGRVAhhFDcDupDs.PssRspLushsthspoAPWs................tssLslPsD.......stcRFssDouosDtKLlDlGQ..........lllATYG..uuussslGDlFlpYoVphhpPpsos	.....................................................t.....hA..PVA.upp.ls..shsPt.h...poss........sh.sl.ppsEhlss.lpp.....oss......hshp.........saslsPhNs....t..hspl.slApsYsha+hTphclhYlPps....u......s.sss......Gp.lthsa.hD...huDsh.Pssps...p...h...uphushlsousWt.....................tssls..h..s.hD...........t..h.a.t..s......s......p.lh.s.st..............hhh.s.u........ts......hGplhhphtl.h.......s.................................................................................	0	0	0	0
+4939	PF00747	Viral_DNA_bp	viral_DNA_bp; 	ssDNA binding protein	Bateman A	anon	Pfam-B_490 (release 2.1)	Family	This protein is found in herpesviruses and is needed for replication.	25.00	25.00	40.90	40.80	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	1122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.80	0.70	-13.80	0.70	-7.34	11	204	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	108	2	0	187	0	910.50	32	95.55	CHANGED	Mpsc.....csssh..uPluPsuYlYhhtpsschh-hluhLShpsssSslslsPLLhsLTVEssFss....sV+o.hsshsG.ullhKlTo..FpPssahFHssctlss.sps..sLs+LC-cARp+FGhpuaps...ss+spTshtsLCsslGhsPspslhalVVspGFKEhlasGpLlsphttsspVplsss-ul+IPLYPhpLF...spphhs-..st.thshsctFl..psFYsssLSchLFhhVaTuhu.ALRhpsscsllcAuh+QhlpDsppssKLsPcKsapuasupphsu...........h-ps.........chMLsDshssELAhSasulah-ulY-.ssshsas-WPllpsu-spts+lsALssaph+LusHVuAhlFSsNSlLYhoclshhssscppssos....p.ohh+hhphssuhsusscps.pDu+tl.chsG.....ssupspcaospHLAhhCGhuPpLLu+hlaYLpRssshsssspups-lhpalss..soushCshCsGcsspoChpTshhRl+sRhPthspss++-PsVhsshSphYuDsDlLGNauph.sl-pc-s.scsu+ss............................................th..sol-RhhhhtphhcYscKt...phlssssGc..shslps+psFlsllsslppslDspVspFhpslhcsps...R-tltsuspuhslshsPaAsuFsPlhsahaaRolLuVlQsLAL.pspuahsDpPlpGpphscWhhppFQolhssFhsshhc+GFLss+slKlspssstsphhshpshtp.Gphstpsh-s+luRlSltsl+slRVKNRslapuups..shupsah++s.........sc++ps.lpGsLuFLLhpaHcpLFPss+hs......sL.FWpplppNphP.ssslhshE-hsshlpFlhphos-Ys-hsllDlsPsslhsaschhhpNplLphhGapsYhhohhshhsthopps.s..aPslLhpps..phuSstEash+spthpssuhssshTushoppshl+slhspRslVoluloIpKYsGhsGNcclFQhGplGahsGuGV-RNLsPss.u.....tshpFMR.p+allAT.hsshll++.sptssssa-s-ll+ptlhhIl..-utshssss.lhslscslusRsp..p.shDDhLahlDs.EhLAcSlhcphsplh-pGst-aSl-shpcVhcsstp..sth....suutsa-Fuuh	............................p.s....sssGPhualYhh.htt..hc.luhLuhpstss.ssslhPLlhGLTVEtsF.h....ssts.hpshsu.ul.hKlos...ats.shhFHssptl..s.sps...slpchCctARpcFGhpsats....s.th.TshttlCttlshpspphhhalVlspuhKEhlahsphh...phtthtpVpls.ttpsh+lPlYs.pL.F................th..p..t.......hshtpth...hsFas.slschLa.hlhsshu.uLRhppspslhcuuhc.hhc-stpsshLssphpahshtspt.ps.............s....................phhlssshss-hAhuhtshh.tusa..-...t...shppWPlhpstps.t............shhpALsta.h+hush.luAhlFSsNSsLY.ocls.hssss.tstu....................t.shh+.h.h.sshhs.hs.ps.p-u+hh...thps...............hshtspcas.pHLAhhCuhsPtLluphhaYLpRsshhths..hptp..shhpalss....s..ss..CphCttpsptsChpTshhRlctRhP.hstt.+tt.hVhsshsp.asDsDhLGsauth.hhcpt-s....sscs..................................................sh-Rhhh.....phhcp......h.s..ss.......u.p....p..lp.....sttsFhthhsslpphl-pps.phhpslhctpp....R-tlttuspshslshsPYu.u.sPlhthhhhRohhsllQslAL.pstshhhspshpsp.hp....tpFQslhtthhhs..ptGFlss+phpsshsp.hshhhs..hhtp.s.........t.shhshpsclsRlol.s.+phRlKNRslapuups........shs.pshht+s...........sppchs.lpGsluFLLhpaHptLF.Psst..s......s..FWptl.pNphP...sthhshc-hps.ltalhpho.pYtthshlslsPsslhphsp.hhtNthLphhsa......p....pahhshhshhhthspps.s...s.hhhh.t....huu..sh-h..h.hphhh.phs.t.h.t.hsshhsppphlpslhptRshVslslulpKYtGhsG.s.pclFQhGphu.h..Gs...+slss.............htF..R.p+allAs.hss.hlhtt.st.h..tss.h.a-sslhcphhhhh...cuss.hshss.hhshhchlu.sRs.p......ph-Dhhhhl-s.phlupphhchhtpl.pps.s.taSh-shhphhct.tt..........st.h.s....h...............	0	0	0	0
+4940	PF01443	Viral_helicase1		Viral (Superfamily 1) RNA helicase	Bateman A, Ahola T	anon	Prodom_1256 (release 99.1)	Family	Helicase activity for this family has been demonstrated [1] and NTPase activity [2]. This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis [3].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.76	0.70	-4.84	72	2712	2012-10-05 12:31:08	2003-04-07 12:59:11	13	100	786	0	67	6146	639	226.40	20	13.31	CHANGED	hllcGVsGsGKSohlpphlpp...........hpsssthhstth......spssphpspplcsh.hshht.....schlllDEahhh..t.l.h..h...spsphsllhGDshQhshpsp.....hsph.sph....sphhshphshhhsshshthtspp..........h.pststpssth.....thsspsh......slthtshspphhpshthp..............shssp-spGhpacsVollhpppss...........spphhhVALTRpppslhhhs	......................................................................................................................................................................................................h....GssGsGKo....p.......l...h...phht................................h...s.h...h.phh.......................................p.hp..s...h.t...h......p....s..........h...h............s.....h...ht.........................schl.hlDEsh...h...h...p....s...h......h...h....l....h......t........h......h.....p..s.....p..........p......l.h..h.h..G.Dsp.Q...h.......s..hh.....s....h........t...t.....h....h..h....t...h.h..s.ph...........................s...h.....t...h.......p....h.s..h....R.s...st..pl.st..hlpsh....................................................t..sppps.h................thsspsh...................hth.hhs.h..p..t.....h..t.th.tp......................................................................shTspp.sQG.....h.....T.....a.c..t..V..............h.l......h...........t....s........p.....s....t...s..........................sppc.hhVALTRtppplhh................................................................................................................................................	0	19	50	61
+4941	PF04521	Viral_P18		ssRNA positive strand viral 18kD cysteine rich protein	Mifsud W	anon	Pfam-B_2612 (release 7.5)	Family	\N	23.10	23.10	23.20	105.30	22.60	23.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.90	0.71	-4.66	10	25	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	12	0	0	26	0	118.30	47	72.80	CHANGED	hsshcsspKhRtplYppLGL..ssVpC+LsussGhsCGMPAAls....h-cucsc.....Lsh.DGaCGEKHcshshShAhR.splpshphcL-pLEc+cEsL+sphpthstst+ssps.s.sstKhs+hKs	..+slhCVSKYRtSVYKsLGL..ssVKCRLPuDCGVNCGMPAAFV....LEcGHPc.....Loh.DGaCGEKH+GYVlSGAWRpAQLRoLNtELDpLE+RtEpLKsQI+sLotst+sssA.sYsPpKls+hK.A..	0	0	0	0
+4942	PF00998	RdRP_3	HCV_RdRP; Viral_RdRP; 	Viral RNA dependent RNA polymerase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_315 (release 3.0)	Family	This family includes viral RNA dependent RNA polymerase enzymes from hepatitis C virus and various plant viruses.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.55	0.70	-6.00	33	17276	2012-10-02 12:54:00	2003-04-07 12:59:11	18	48	263	228	1	13782	0	190.90	62	44.48	CHANGED	hhshsushh...sppcphh.lst.hssshhhtsHNpshsNhpRulhERVahVp..tptp....lhs..........cPh.ssFcc.lpthtppltphlh...ptsslo.pchsp.YpGt+tphYp+AlpS.lshpslppc.DuhLcsFlKsEKhslssKsDssPR...lIpPRsPRYNVtlGpaLRhhE++hh+s......lspsatGsohhpGYospptuchlhptWppapsPsAlGhDsoRFDQHVShcALcaEHSlYpusatssp...pLtclLshQLhNpGsuhss-Gh.h+YphcGCRMSGDhNTShGNsllsshhspshh+ths..lcspLhNNGDDCVlIsEpsshcpspp...slpchatcaG.FsspsEcPsYclEplcF..CQspPlhsss.tashsRp.hsshuKDshuhsshpss..ssspsWlsulupsGhslsuGlPlhppFaphhhpsst......thstphhsspash.......shhthhuh.thshpstsssptsRhSaaL.uaGlsPppQhtlEsthsphplptp	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................V...T...E...p.DI.R..sE...E.....tIYQsCsLtPpA.....RpAIcSLTERLY...lG...GPhhNS......K.Gp...sC.GYRRCRASGVLTTShGNTL...T........CYl.KA..pAA.......C.......R.....A..............A....t......Lp......D.......sT.......M....L..V.......CGDD...LVVI.sESsGspEDtt....sh....................................................................................................................................................................................................................................................................t..............................................................................................	0	0	0	1
+4943	PF02407	Viral_Rep		Putative viral replication protein	Bashton M, Bateman A	anon	Pfam-B_1223 (release 5.2)	Family	This is a family of viral ORFs from various plant and animal ssDNA circoviruses.  Published evidence to  support the annotated function "viral replication  associated protein" has not be found.	25.80	25.80	26.10	25.90	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.04	0.72	-3.98	19	1309	2012-10-02 18:54:06	2003-04-07 12:59:11	11	2	283	2	9	1241	181	77.10	47	29.31	CHANGED	uppWsFTLNhsst.......hs.l.hs-clpYAlhtcEcu.p.GpcHLQGalphK++.ppLsplKplhsu.puHhEhsR.Gosc-scsYCpKE	..........................h..hW.sFTl...ot...................t....hl...h............s.hpY.hlhGcEtspp.tTPHLQGahph..ppK..p.p.....hs.plK.thhss....psHlEKAK.GoDppNccYCSKE.........................	0	8	8	9
+4944	PF05101	VirB3		Type IV secretory pathway, VirB3-like protein	Bateman A	anon	COG3702	Family	This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes [2]. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins [3].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.85	0.72	-4.00	24	967	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	663	0	249	799	41	88.50	20	43.83	CHANGED	Muttt............sPla+uhsRPshl..hGsst-hlhhs.slhsslLhhsstshhsslhslslahhs....phhscsDsh.hptlah+.......phph+saa.....tsp	..................................ssla+uhTRPshl..hGls..hthhlhs....s.....hh...s.sh.....l......hl.....h....h...p......t......h.......h.......h.h.....l.l..s.h.s...l.ahht........hhss....ccDsh.Fhtlhhp.........p.p.t.ha...t.....................	0	42	134	187
+4945	PF04335	VirB8		VirB8 protein	Mifsud W	anon	Pfam-B_1984 (release 7.3)	Domain	VirB8 is a bacterial virulence protein with cytoplasmic, transmembrane, and periplasmic regions. It is thought that it is a primary constituent of a DNA transporter. The periplasmic region interacts with VirB9, VirB10, and itself [1]. This family also includes the conjugal transfer protein family TrbF, a family of proteins known to be involved in conjugal transfer.  The TrbF protein is thought to compose part of the pilus required for transfer [2]. This domain has a similar fold to the NTF2 protein.	20.40	20.40	20.50	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.36	0.70	-4.75	104	1418	2012-10-03 02:27:23	2003-04-07 12:59:11	8	5	855	7	317	1203	73	202.90	19	86.07	CHANGED	putph.p-chspsptpp+.phhhl.....uhsuhhluhhssh.ulsh..hssh..pp.h.P...allp.VDptsGtsphlssh....pph....pst.s-shhphhlspalp.sRps.hssssh.p..psappshhh..osssstpphpsah.....t.t...psPhshhupps.h...pVclpSl.shh....ss.....p......shp.Vcapcph..pptsssh....tsp.pasuhlshth...pssh.sppphhtNPLGhhVpsaphspE	..................................................................ph.tpphtthptpp+thhhh......uhhshh..lsh..hhsh.u...lsh....hhsh....pp.hhP...allp..lDp.t..Gp..sp.hls..h...pst........php..s.cshschhlspal....p.hRps.hs..sl..p.....pshpps.hhh..osspst.pphpshh..p.....pssh.pph..tppt.l........plplt.Sl...shh.......ss.............s..................shp..Vc...a..ppph...hptssp.............ttp.papuhlsa.h...p..s.h..sppph......h......hNPhGhhVssaphst......................................................................................................	2	56	177	240
+4947	PF00286	Flexi_CP	virus_P-coat; Virus_P-coat; 	Viral coat protein	Finn RD	anon	Prosite	Family	Family includes coat proteins from Potexviruses and carlaviruses.	22.90	22.90	23.40	23.10	22.20	22.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.69	0.71	-4.48	17	1308	2009-01-15 18:05:59	2003-04-07 12:59:11	15	4	134	2	0	1218	0	129.90	41	54.26	CHANGED	SNshAosE-lttItsshps.htlPssslstshhplshhCscsuSSshss.pGss.h.s.usshtsls.uhh+tpso.LRphCphYA.llWNhhLspNpPPAsWushGap.psKFAAFDFFDuVpssAAlpPspGlIRpPTptE	............................thAsstplttlhthhtt.hGlspppht.p.shhclshtCucsuSSthsshhGss........s.....sh.sp.s-l.s..ul.h.+..phs.T.LRpFCthYA......lVWNhhLtpspPPANWsttGFptssKFAAFDFFsuVsss.AAl....p..P.hpG...lhRtPTctE........	0	0	0	0
+4948	PF01347	Vitellogenin_N		Lipoprotein amino terminal region	Bateman A	anon	Pfam-B_1280 (release 3.0)	Family	This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100.  These proteins are all involved in lipid transport [1]. This family contains the LV1n chain from lipovitellin, that contains two structural domains.	21.00	21.00	21.10	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-12.79	0.70	-6.29	44	1005	2012-10-11 20:00:59	2003-04-07 12:59:11	17	42	272	1	433	992	1	434.80	17	32.52	CHANGED	apss+pYpYpacupshsuL.p.husthuGhtlpuclplpsp.........spsphhhplppsphsphpthhsp.......cshhsssp..........lphphhshhppPhchphssGh.lsclhsspsssshtlNlh+GIlshLQls.hpsspth.pht....................EsslpGtCcThYslpp.sp.....................phlplsKo+shspCpp+hthphGhs.h.sphp..sppppps..lpposssphhlpsp.s..shhIppupsppphhlsPh.htp.ptupspu+ppLsLhphpsps...hs.ssshpshssLlYphssph.....................................................................................................................................................................................t...hPhhhhphssttt............plscplpp.l.ptstphscpcs..+.FspLlpllRssstcplpplhpphtsp...................phhphahDAlspuGTtsAlphlpphlps..cclpshEAApllsshspss.tsspchhchhhpLspssplppp.hLppouhLuaushlpphpss.....................psss.pchlp.ltpphp..pAlsctcp.chhlhl+uLGNhGpspslpshp.hL.upt.......plsthlRlthlhuLcpl..scppP+hlpsllhplahspsppsE..lRhsAhhhLhcopPshshlpplAphspp-s..shQVsuhlhStlc	.........................................................................................................................p.Y.ath..ps.........t.h..........t....t...............s.shhhps.l.l.t.............................t.p...h.h.p..h......p..h...t.....h.....t...t.................................................................t...h......t..h....Phhh..th.............p..Gh...l.t.pl..hs..ts..s.h....h.Nlh+ulhshhQhs..hpt..tpt................................................Es..sh.G.Cps.Y.hp...........................................................................h.lh+..p.shppC...p.t.h......h....s.h.t...........................t....h....................h..h...p.t..t..................h.ps.s.p....h.h...............t.....h..h..s.p.pl.h....p...tt..........................sl...h.t.................................................................................................................................................................................................................................................................................................................................h.t....................th..hp...htp.................................tt........t.........h..hhp.hp.hp.pp.....l.thh....tph.............................................................................hhhpsls..hts..sh..hhhphh......tp.t....h...h..h...h...............s.s.....thhp...............h..........................................h......hhht.h.th.h...t.h..................................................................h.tth.h.......h..t...ht...........t...................ph.hhlhsl..t.Nh.....t...............t...h....h...hh.t................t.........ph.....hl.sht...........h.....p.hpthhh.lh.p...t.....c..hRhhA.h.hhhht..s.P.s...htth.h...h.....-...........ph.thh.s........................................................................................................................................	0	145	187	351
+4949	PF05090	VKG_Carbox		Vitamin K-dependent gamma-carboxylase	Moxon SJ	anon	Pfam-B_6307 (release 7.7)	Family	Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl  carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase [1].	20.40	20.40	20.60	20.40	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.66	0.70	-5.63	10	332	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	226	0	183	348	246	332.40	23	68.03	CHANGED	ulFRllFGlLMhl-lhpctuhGalDp+aL-Pphsh+F.hF-alpPLPhshMYhlallMhluAlsIMLGh+YRlSslhFhLsahYIaLLDKToaNNH.YLhuLLuFhLlalsANR...YaSlDuhh.NsslRss.cVPhWNYshL+sQlFIVYFaAGltKLssDWlpG...uh.s+HWLhssaclhl.s-Llsh.lVHas....GLlaDLhlsFLLhac+TRhhuhhhlshFHlMNSpLFsIGMFPYlMLAsoslFFsssW.........s+th...h.phLphlh..............h.t..phhpppsshsp...hh.......ccthhp.tppPhltp+lushFslhahh.QLhLPapHFlhpGps.WTpthYtaSWcMMl+o+ss.asphplcDspTGcpsalsPpsF...pQp+phpspsDhlhQYAppLupphsppshs.....plpIYhDlaVSlNGRhpQRlhDPclDlhpscWssFppssWlLP	.......................................................................................................................hRh.huhhh..h.....h.............................h...........s.....h.......h........t......s................h..pa..h....h.p.h..h...s.h....s......h.hh..hl.ahl..h.h.l...hu.h.hhhlGh.hh......R.h.u.h....h.h....h....h.........l.....a.h.h.l...hh.st.s...s.a....s...+......h...l.......h.tl.l.hhhh...h..h..hsss..p......hhSlD.....sh.....h....p.......p...........h.......t..........p.........t.......p........l........s...........h........W.................shhl.lp........hQlhllYhh..AGltK.l.p...s...-...WlpG...........shh..p.ha........hhs...h...p..h......l...........s...p........l..h.......s........h......h.lt...h........h......h..u...ll..h-L..s.h.sh.hL..h....h..c.t.....o......R...h..uhh..hshhFH.h.h.su.h..l...h..s..IG..h..Fs.a..hhl.us.s..l.F..h.s.sph...........p............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	77	128	162
+4950	PF04649	VlpA_repeat		Mycoplasma hyorhinis VlpA repeat 	Kerrison ND	anon	DOMO:DM04353;	Repeat	This repeat is found in the extracellular (C-terminal) region of the  variant surface antigen A (VlpA) of Mycoplasma hyorhinis. Mutations that change the number of repeats in the protein are involved in antigenic variation and immune evasion of this swine pathogen [1].	25.00	25.00	59.10	30.80	23.40	14.00	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.71	0.73	-5.60	0.73	-4.18	6	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	3	0	16	51	0	13.00	98	28.24	CHANGED	KTENTQQSEA.GT	KTENTQQSEAPGT	0	0	16	16
+4951	PF01660	Vmethyltransf		Viral methyltransferase	Bateman A	anon	Prosite	Family	This RNA methyltransferase domain [1] is found in a wide range of ssRNA viruses, including Hordei-, Tobra-, Tobamo-, Bromo-, Clostero- and Caliciviruses.  This methyltransferase is involved in mRNA capping.  Capping of mRNA enhances its stability. This usually occurs in the nucleus.  Therefore, many viruses that replicate in the cytoplasm encode their own [1].  This is a specific guanine-7-methyltransferase domain involved in viral mRNA cap0 synthesis. Specificity for guanine 7 position is shown by NMR in [3] and in vivo role in cap synthesis [4].  Based on secondary structure prediction, the basic fold is believed to be similar to the common AdoMet-dependent methyltransferase fold [5]. A curious feature of this methyltransferase domain is that it together with flanking sequences seems to have guanylyltransferase activity coupled to the methyltransferase activity [5]. The domain is found throughout the so-called Alphavirus superfamily, (including alphaviruses and several other groups). It forms the defining, unique feature of this superfamily [2].	20.70	20.70	20.70	21.10	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.28	0.70	-5.79	122	1584	2009-01-15 18:05:59	2003-04-07 12:59:11	12	52	396	1	1	1647	0	318.10	19	22.63	CHANGED	hsaslstpttphLpph.....GI.hsshus.sHsHsssKslEs.hhhphlhshl.sp....sssh..ltlKssKh.phlpptt.........hs...........hhN.hlss+DhtRY.....ss....................................................................p.......................tp..h.h........ttp....hsahtDsLaahshpplsshh.ppsphppLhuolVhP.sEhhh............................tpp..ShhPplYshphp.....................ps..................................................p.......hhahP-uptutuYppsh.sthpaLpsspl..h.tt..................shslphlpShsupHlhhIp+.spths.....................................................................sphtoFt...ctlhhs.....................................phhh.p.hs...p...........phslspshhpplhpYlcol+phshpss.....................................................hu+lpphhsc	................................hs..t.phl.ph.....tl.h.pspt.h....tsHshstshcp...h....hphh........tphs......tshh........l-lGus.hphhhpsp.....................Hs....ssshhss+DstRh.....hp.....phtth.t.ph.t......t...hp..t.....................................................................................hC.p.s................................................................................................................tsCp.hps............t......hshhhpslY.....hshcshsphhhpptht.hhhsshhhs.sphhh.............................tpt..shhs..p.h..s....htctp..................................................p.....hha....stusht..Yscshp.lhpahpsshh.....h..st...............................shhh-hlh.s..hsshh..hh...plst..ssthh.........................................................................p.hs.......ptl.....h..............................t.hl.thhp....t..............hh.ht.....hpph.phl.......uhpphhhhsu....................................h.........p...................................................................................................................	0	0	0	1
+4952	PF00695	vMSA		Major surface antigen from hepadnavirus	Bateman A	anon	Pfam-B_168 (release 2.1)	Family	\N	29.10	29.10	29.30	29.20	29.00	29.00	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.32	0.70	-5.25	4	23454	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	96	4	0	17711	0	209.40	74	95.40	CHANGED	hs.s.uKshsscch-Gs.lh.ph.Aup.lP....Gsh...GphsTh.H..lhs+s.psptlpTh.pshs.PtusupR.uhcpPTPhoPP.hshpPctspKsppuF+Qh.p-...tPpsssphsP..........s.hc.pss.sPllpstShl.oh.........sshltsPsLspc....sohuGlLusLlGL.VuFFLLTKILpIhppLDWWWhSLS.PtGp..CshQNotuQTSsHhssSCP.sCPGFhWhYLRhFIIFLLlLLlshshLhlh.s......................................................pShhhuKh.WE.sSAhFS.lS.LlP..Qh..hluLThhLhLIWMh...usplhshLo.hhsL.ALFFp	.................................................................................................................................................................................................................................................-........................LT+ILsIPpSLDSWWTSLNFLGGsssC.GQNSQSPhSNHSPT..SCP.PhCPGYRWMCLRRFIIFLFILLL.CLIFLLVLLDYQGMLPVCP.LlP.....G...S....S....T.TSTG.....PC..+...TCTTP..AQGTSMaPSCCCTK.PoDGNCT.CIPIPSSWAFuKaLWEWASsRFSWLSLLVPFVQWFsGLS..PTVWL.shWMhWaWG..................................................	0	0	0	0
+4953	PF03762	VOMI		Vitelline membrane outer layer protein I (VOMI) 	Finn RD	anon	Pfam-B_3481 (release 7.0)	Family	VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure [1] that consists of three beta-sheets forming Greek  key motifs, which are related by an internal pseudo three-fold  symmetry. Furthermore, the structure of VOMI has strong similarity  to the structure of the delta-endotoxin, as well as a  carbohydrate-binding site in the top region of the common fold [2]. 	25.00	25.00	25.50	25.50	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.75	0.71	-11.48	0.71	-4.32	22	120	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	63	2	78	127	1	149.20	36	64.05	CHANGED	hlpsspsssaGsWtt.ptCPsGpaspGhplKhEssp....s...........D-TulNulpLaCpphs....................................................................................................sppphlhSs-usaGpWp.phpaCPtsthllGFpL+s-.ppt..tDcsussNhthhCt..........spt..ltGss..sa..GsWsssph.......................................................................Cst.G.slCGlpoplEsspu..............................................................htD.DTuLNslplpCC	...................psssss.aGsWs..p...hCPsG.aAsGFplKsEssQ....sh..s.............................DDTALNuIcLaCspst......................thlpStp.GtaGp..Wo.p..aCP.s...s.hlhuFpLRlE..s.ps.......uDsTA...sNNlpFpC...........ssst.Lp...Gsu...hsa..Gpau.p.h.p........................................Cst......ulCGlpT+lEt.pG.....hh.DDTuLNsl+hh.CC.....................	0	37	43	60
+4954	PF00434	VP7		Glycoprotein VP7	Finn RD	anon	Pfam-B_116 (release 1.0)	Family	\N	25.00	25.00	25.60	25.60	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.33	0.70	-5.52	8	4737	2012-10-01 19:08:57	2003-04-07 12:59:11	13	1	694	28	0	3775	0	272.50	76	99.95	CHANGED	MYGIEYTTILhhLIShlLlsYILKolT+hMDaIIYRFLhVlVlluslss...AQNYGINLPITGSMDTAYsNSTQ-psFLTSTLCLYYPsEAsTEIsDsEWKsTLSQLFLTKGWPTGSVYFpEYuDIsoFSl-PQLYCDYNIVLh+YssslpLDhSELADLILNEWLCNPMDITLYYYQQTsEuNKWISMGoSCTlKVCPLNTQTLGIGCpTTsssTFEpVAooEKLVIpDVVDGVNHKlNlTssTCTIRNCpKLGPRENVAIIQVGGusILDITADPTTsPQspRMMRINWKKWWQVFYTVVDYINQIIQVMSKRSRSLDoAAFYYRV	......................IEYTTlLha.L.ISl.lLLNYILKS.lTphMDaIIYR.FL..LllV.l...l.sh..s+...uQNYGlNL.PITGSMDTsY..sNS.TQp.E..s...FLT..STLCLYYPTE.........A.........uTp.........IsDsEWKDTLSQLFLTKGWPTGSVYFKEYosIssF.SlDPQLYCDYNlVLM...KYD.psLELDMSELADLILNEWLCNPMDITLYYYQQosEuNKW..ISMGoSCTlKVCPLNTQTLGIGC.TTsssoFEpVAps.EKLsIsDVVDGlNHKlslTTs....TCTIRNCKKLGPRENVAlIQVGGuslLDITADP.TTsPQhERMMRlNWK+WWQlFY.............................................	0	0	0	0
+4955	PF00522	VPR		VPR/VPX protein	Finn RD	anon	Pfam-B_100 (release 1.0)	Family	\N	20.80	20.80	25.60	25.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.41	0.72	-4.17	12	5858	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	90	10	0	5609	0	89.30	80	93.70	CHANGED	cEpsPts...pss.REsapEWlt-hlcElpcEAlpHFshcLLhtlhpahappatDp.st.....shchlpllQ+AlFlHa+pGCp.........cuRhGt	.......................M.EQAPED...QGPQREPYNEW.TLELLEELK...s....E....A.VRHF.PRsWLHuLGQaIYE...TY..GD...TW...s...G.....VEAIIRILQQLLFIHFRIG.Cp..........HSRIG.IhtpRRsRNG......................	2	0	0	0
+4956	PF03643	Vps26		Vacuolar protein sorting-associated protein 26 	Finn RD	anon	Pfam-B_4396 (release 7.0)	Family	Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking.  In particular, Vps26  assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35 [1]. This family also contains Down syndrome critical region 3/A.	20.20	20.20	20.30	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.80	0.70	-5.62	8	653	2012-10-02 22:29:00	2003-04-07 12:59:11	10	9	323	8	411	631	10	247.70	41	79.71	CHANGED	FGsss-I-IphsstcsRKhl-hct-......cGph-cthlahsGEoVoGpVslslKc.u+KlEHpGI+lEF............lGQIEhaYD+G..........................Npa-.FhsLs+ELAhPGELppspo.aPFEFspVEKs....YEoYtGsNV+LRYaLRVTlsR+h..oDlsKEhDlhV+.............sa...sshP.......................................-sN............ssIKMEVGIEDCLHIEFEYNKSKY....HLKDV.......IlGKIYFLLVR...IKIKaMElulI++EooGs.GPNsasEoETlsKaEIMDGAPVRGESIPlRlFLuGYDLTPThRslNpKFSVKYaLNLVLVDE-D	.....................................................................................................h.h.h.t......tt..h.h............................pt.h.cth.la.h.sGEslsG.............t...V.sl.p.+p..sp+l...c.....HpGI+lph...........................lGpI..........Eh...a..h..-ps..........................p..h.-..Fls.hsp-.....L.sh.P....G.....c...l.........p....s..po.asFcF........p.......lcK...........Y.EoYpGhN..V....cl+Yhl+..sol.....Rph....s-l.s.+.p.h.-.h.h...Vp............................sh.....sh...P...........................................................-.hs.................................ss.I.KM.-.V.G...I..E.-..C..L.HI.EF.EYsK..ocY..........cL.+Dl...........IlG+I...YF..LLVR.....lK...IKpMElpll++Eos.......Gs....u...s.s.h...h.p.........E.....scTls+aE......IMDGuPs+G................EoIPIRlaLss...h..p..hoPThc.s.....lN.ppFSV+aaLNLVllD--............................................................................................	0	146	219	321
+4957	PF03997	VPS28		VPS28 protein	Bateman A, Wood V	anon	Pfam-B_6317 (release 7.3)	Family	\N	20.30	20.30	20.40	20.50	19.40	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.28	0.71	-4.68	6	333	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	284	19	223	325	4	178.50	41	76.05	CHANGED	huELYAIlpsl-pLEKAYl+DslSsoEYsusCpKLlsQaKsshpplpsp....thsSIEcFscKYRLcCPsAlcRIc...............cuhPITlcc....................DpussuKsIA-lVppFITsMDuLRLNhpAhDpLaPhLs-LhsohN+lSclP..DF-s+pKlpcWLh+LspMuASDELo-sQsRQhLFDLESAYsuF.phLp	..............hAELaulIhTl-tLEKA..Yl+Dsl.os.sE......YTssCs+LLsQYKshhpp.hpst.....................ph.ss.l......-p........Ftccac.........l.-CPtAhcR.l.+...............pGhPhTlc...c........................................................s..p..u..s..s..u.phIA-ssppFIThMDsL+Lph.hAhD............p...L.aPhLp-Lhpohs+l......op..........................DFE.............s+.......tKlhpWLhpLspMpAo-ELs-p.QsRphhFDl-pAYpuF.thL..................................................................	0	74	120	184
+4958	PF04133	Vps55		Vacuolar protein sorting 55 	Wood V, Finn RD	anon	Pfam-B_25168 (release 7.3);	Family	Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase.  Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells [1].	23.30	23.30	23.60	24.20	22.20	23.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.57	0.71	-4.36	27	382	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	262	0	242	344	0	116.20	37	87.97	CHANGED	llhLShhluhGhlLlILuCAL..asNaaPLhsllhalluPlPshl.....spphtssssasspt..........h.-hupFlTGhlVlSuhuLPllLtHssl....IshsAhhholsGshllasoIlhahhhFsts--c	..............lluLSFhhAlGhhhllLuCAL..............apsaaPLhVlhhYlluPl.PhhI.....sp+h.s..s..ss..-.hsssu..........sh-huhF.lTshlVVSuhuLPllLAHu..s..l.........I.phsAhhhslsGshllasTIlsFhhhFtptpp.h..........................	0	61	118	185
+4959	PF00558	Vpu		Vpu protein	Bateman A	anon	Swiss-Prot	Domain	The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing  the release of viral particles from infected cells. The VPU protein binds specifically to CD4.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.92	0.72	-4.42	16	6152	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	58	8	0	5351	0	71.70	65	97.50	CHANGED	Mhphph.....lullulhlslIl.sIllWsl....lahcY+ch++Q....+cIpcLlcRIRERAEDSGNES-G-pEE.LssLlc.....hGasNPhh...L	.............M.sL..I.....h.u.I.V.uLlVAh.Il.AIVVWoI....VhIEYR.K.ll+Q....RKID.RLI-RIRE..RAEDSGNESEGD..pE..E.....LS.sL...VE........MGc.hs.hs..ls........................	0	0	0	0
+4960	PF03852	Vsr		DNA mismatch endonuclease Vsr	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.60	20.60	20.60	20.90	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.39	0.72	-4.36	7	1075	2012-10-11 20:44:43	2003-04-07 12:59:11	10	8	981	3	248	738	161	73.40	49	47.87	CHANGED	sDhhss...tpRptsMp.ps+o+sT+PEhtLtphLaulGhRYRhpctsl.G.....pPDlVhsph+lslFlcGCFWHG+sCtht	.........................Dhhsp...tpRS+sMp...uIto+D.Tt..Eht...L.tphL..pupGl.p.aRlp....c...t....s....LP.G................+PDhVlsc.....Y+sVIFsHGCFWHtH.c.C...hh...........	0	76	158	204
+4961	PF00093	VWC	vwc; 	von Willebrand factor type C domain	Sonnhammer ELL	anon	Published_alignment	Family	The high cutoff was used to prevent overlap with Pfam:PF00094.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.35	0.72	-3.86	20	3816	2012-10-01 23:42:56	2003-04-07 12:59:11	13	320	140	1	1998	3212	3	59.00	33	11.54	CHANGED	Ch.psGphYpss-sWpss.........Cp.pCsCps........uplhCcplh..Cs.......ssCsss..................s.GECCs..hC	..................Ch.hsG..p..hYp.sG..-pWp.ss.............Cp.pCpCps..................................GpltCpp....ht....C..s............hsC.sps............................h.hssGpCCP..hC..............................	0	372	529	1087
+4962	PF02020	W2	IF5_eIF4_eIF2;	eIF4-gamma/eIF5/eIF2-epsilon	Bateman A	anon	[1]	Family	This domain of unknown function is found at the C-terminus of several translation initiation factors [1].	30.00	30.00	30.30	30.50	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.03	0.72	-4.03	77	1188	2012-10-11 20:01:00	2003-04-07 12:59:11	13	35	311	14	716	1099	4	83.00	29	12.25	CHANGED	pctphshLtulpch...h..hc...........s.phh..sh.l......tllptLY.-tDllsE-sllpWhpc...t....stpspsp..lh.cpsptFlcW.LppAEEEsp---	......................................ptplphLhulpphs....hc..........psphh..sh.l......pllpthY..-tDll.pE-sllpWhpc.....p..............h....s.tcspth.............hh..cp..s...psFlp.W.LcpAEEEsppp......................	0	217	343	531
+4963	PF03716	WCCH	WCCH_motif; 	WCCH motif 	Finn RD	anon	Pfam-B_3194 (release 7.0)	Motif	The WCCH motif is found in a retrotransposons and Gemini viruses. A specific function has not been associated to this motif [1].	20.80	20.80	21.30	21.20	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.74	0.72	-6.95	0.72	-4.45	30	1359	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	739	0	2	1020	0	24.40	64	20.75	CHANGED	PlhpsCsCPHCPRH.ppppshsppAa	......PlppPCCCPHCPRH.Kp.psMspQAH...........	0	1	1	1
+4964	PF00458	WHEP-TRS		WHEP-TRS domain	Finn RD	anon	Prosite	Family	\N	27.30	27.30	27.30	27.50	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.63	0.72	-4.29	65	996	2009-09-10 19:30:04	2003-04-07 12:59:11	15	80	141	15	582	981	8	55.30	39	11.86	CHANGED	LhpplspQG-hVRcLKucKAsKs..p.lcsAVppLLsLKtpa...KphoGp-hpPs...s..s.u	................LhpplspQG-hVRcLK.......up....K....A.sKs....p.l-.........sAVppLLsLKtph....cptp.Gpchpsst.......s.......................	0	175	232	425
+4965	PF00110	wnt		wnt family	Sonnhammer ELL	anon	Prosite	Family	Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families [1].	19.40	19.40	19.60	19.60	17.70	17.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.55	0.70	-5.23	104	10329	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	7256	1	979	7789	0	159.90	55	94.96	CHANGED	hCsplsuLs....cQpplCpppsc........hhtulscGsphulpECQaQF+pcRWNCSshstt.................................shFsp.llppG..oREoAFlaAIouAGVsauls+ACopGpl.psCuCDppt....................pststtt......................................................................WcWGGCSDNl.caGhpFu+pFlDupE........ttpssRsl..MNLHNNcAGRpsVppphcpcCKCH...GVSGSCslKT....................CWp.plssFRplGshL+c+Ycs.AhcVphpppspttth...............................................................................................p.ph+.....s..........sppDLVYl-pSPsaCpps.ph.GshGTpGRpC.............Nco.Sp.........uh-u.CshhC..CGRGasopphphsc.cCpC+.Fp.....WCChVcCcpCppphphasC+	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................+.T....................CWh.pL..P.s..F..R..s..VGDsLKDRFDG.A.SR.VMhsNsshp.t...ss.p.p.spsssptsst..................................................................................................+pRYpFQL+Pa.NP-HK............sP.............GsKDLVYLEsS..P.s..FCEK..NP+..............L.........G....I....G....THG.......R..tC..............................NDT...SI.................GVD..G..CDLMC..CGR.G.Y+T.p.p.h.hl.lE.RCs.......................................................................................................	1	210	287	607
+4966	PF01822	WSC		WSC domain	Bateman A	anon	[1]	Family	This domain may be involved in carbohydrate binding.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.83	0.72	-4.05	162	2216	2009-09-11 06:24:10	2003-04-07 12:59:11	14	209	242	0	1812	2200	48	80.00	26	17.70	CHANGED	YhGC......as...........-s................hhsss.thssssho...sptC.hshCt....tt...u.ash......sulp..up...pCaC..Gsshsstt.t.sspt..............Cs.hsCs.Gss...s......ph.CGG	................................................hGCap.....................-s.......................tt.thh...st...ths.ssshT.......sptC.hsh.Ct..........tt......u..as.a............uGlp...hup.......cCa..C.........G..s...s...hs...s..s.s...tt.s.stsp....................C....s....hs.Cs..Gss....s..........ph..CGG..................................................................	0	824	1197	1552
+4967	PF02165	WT1		Wilm's tumour protein	Mian N, Bateman A	anon	IPR000976	Family	\N	19.60	19.60	21.80	20.50	16.90	16.80	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.16	0.70	-5.32	8	147	2009-09-10 17:23:11	2003-04-07 12:59:11	10	10	53	6	33	118	0	217.70	64	67.01	CHANGED	MGSDVRDLouLL...PPVSSLsuuuGuC.ulPVuGusQWAPlLDFH.PGS.PYuSL..............usHSaIKQEPoWG.uuDPaE...DPHCGLuA.FTVHFSGQFTGT.GsCRaG.AFG...........................pPssuQuRMFPNuPYLPuClDSsPshRNQ.GYusVAhDGsPSYGHTPSHHsuQFoNHSFKHEDslS.QooluEQQYsVPPPVYGCHsPoDoCsuSQALLLRNsYNS.DNLYQMsSQLECVTWNQMNoLuSohK.................uHuuuYEoDspos..PhLhSCSuQYHIHTHGV..FRGlQDVRRVPGlsPslVRS.SEooEKR	...................................................................................................s..HShIKQEPsWs.ss-Phc...-.ps.LuA.FTlHFSGQFTGo.usCRaG.sFG............................pss.t..s..RMFssssYLssCh-s..s.RNQ.GYusVsFDGsssYGHTP..oH.HssQFssHSFKHEDshu..QQsohG.-.QQYsVPPPVYGCHTPoDSCTGSQALLLRsPYsS..DNLYQMsSQLEChsWN.hN.LuuolK..................................................................sHuoGYES-spos..PhL..CuuQYRIHTHGV..FRGIQ.DVRRVPGlAPslVRS.SEosEKR.................................................................	0	2	5	15
+4968	PF03303	WTF		WTF protein	Mifsud W	anon	Pfam-B_4183 (release 6.5)	Family	This is a family of hypothetical Schizosaccharomyces pombe proteins. Their function is unknown.	25.00	25.00	64.20	62.40	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.78	0.70	-4.96	8	19	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1	0	19	27	0	238.50	41	80.87	CHANGED	MKNNYTSLKSSlDEtDEhKTDHEIDLEKG.LPEYsSEEEusLPPYSDhu+l.......Ss.......sPN....................sHRcpcsScSsDNpos..LlKLLIShlulhVlNhsA.lCh.saKcuhFtcautu-hVLFGlhsh.lCslshIhLhYFYETWsKAV....KVTll..................shuhGLhshp+chhlhhahhah..IlChlLFsshppGpL.ls+uhltS.....sColSAtllhhl.sVsIPhaphcphhstLhpV.hlppshsls	..MKNNYssL+SslDEtsp.hKs......DpEIDLEKG.LPEYsSEEEuTLPPYSDhupl..........us.......sPN..............................s+Rcsc.ssco...scNuss..LlKLLIShhslhllNhsA.lChL.a+cuhFpsauhsphslFGhaCh.sCslshIhLhaFYETWTKAV....Khslh...................................................shuhGlhp.h+chhshhahhhh..lhphhLhshhppstLsL.puhltu.....pCSluAtlhhhl..lhl..ahhcphh.t.hps.hlppshh.................................	0	19	19	19
+4969	PF04932	Wzy_C		O-Antigen ligase	Moxon SJ, Bateman A	anon	Pfam-B_5033 (release 7.6)	Family	This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL [1].	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.45	81	1431	2012-10-01 22:04:45	2003-04-07 12:59:11	10	29	1205	0	366	4539	2057	165.80	18	32.83	CHANGED	hshllh..hhslhhotSRuuh...luhhlshhhhhhhhhtthhtth................................................hhhhh....hlhshslsshh...............................................................................................................................tphhhplhstststs................................stRh.t.happuhphhtpp.Ph....hGhGh..................hht.h.......hh.hh.sthhtpsHNhalphhschG.lhGhlhhh	...................................................................................................................................................................................................................................................h...llh..hh.slh.h.o.tSRu..u.h.......l.u..h....h..l..s...h....h...l.....h....h.....h......h........h....h....t......h......t.....t...t..t...h...................................................................................................hh.hhh............hlhs..hhl.s.h.sh.......................................................................................................................................................................................................................................................h.p....p...h...h...t..p..l...h...p.tt.t..p..s..t.........................................................................................................shRh.t..ha....p....s.ul.p....h..h.....p...c....p...Pl......................hG..h.Gh..sth.....................................tthh.p.t.h.............h.h.....t...h..h..h.....t...h..h....t....p..s..HN.hL.phhsptG..ll.Gllhh.h.............................................................................................................................	0	159	261	325
+4970	PF00739	X		Trans-activation protein X	Bateman A	anon	Pfam-B_458 (release 2.1)	Family	This protein is found in hepadnaviruses where it is indispensable for replication.	21.50	21.50	21.90	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.79	0.71	-4.27	5	5949	2009-09-16 23:40:58	2003-04-07 12:59:11	14	7	78	2	0	4549	0	103.30	87	89.74	CHANGED	MAARLCCQLDPARDVLCLRPVGAESRGRPlPGPhGuLPuuuuSAVSoDHGAaLSLRGLPVCAFSuAGPCALRFTSA..RRMETTVNsHp.LsKsL+KRTLGLSuMSToDL.EAYFKDpLFT-WEELGEEhRLpIFVLGGCRHKLl	....................RhhCQLDs.sRDVLCLRPVuAESpGRPhsGshGslsssSsssVsssaGuHLSLRGLPVCAFSSAGPCALRFTSA..Rp..METTVN.....A...+....p........L....PKV....LHKR........T........LGLS.A.MSTT.DL...EAYFKD.ClF.KDWEELGEEIR......Lhl.FVLGGCRHKLV...............	0	0	0	0
+4971	PF00860	Xan_ur_permease	xan_ur_permease; 	Permease family	Bateman A	anon	Pfam-B_1593 (release 2.1)	Family	This family includes permeases for diverse substrates such as xanthine Swiss:P42086, uracil Swiss:P39766 and vitamin C Swiss:Q9UGH3.  However many members of this family are functionally uncharacterised and may transport other substrates. Members of this family have ten predicted transmembrane helices.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.20	0.70	-5.98	20	15557	2012-10-03 01:44:59	2003-04-07 12:59:11	15	19	3998	1	2877	9790	2601	366.40	23	85.08	CHANGED	tphlhhGLQahhuMauusllVPlllutu..........t..lhuhshlsuGluTllQsh....hhGhplslhhGsSFsals......hhhhshG.............shslsulhGullluullhhlluhhGhh.hLh+hhPPlVsGsllhlIGLuLs.luhsthuss....ssu....hsssphhtlulsslshslhhshh...tpshhpphulLlGlhsGalluhhhG..hlshss...............ltstsahths.sh.ausPh......hshslllshhslsllslhEslGshhuluplssppht....p.slp+uhhu-GluolluuLhGu.hPsToaupNlGllslT+lhSphlhhsAullhllhGlhsKluuLhssIPssV.lGGshllhaGhlhuuGlphLppschc..pscNlhIlulolslGlulsth.hh	............................................................................................t..tlhhGlpph.lsM..hhshl.l.......s.Ph.ll...uts........................................t...h.........lh..sss....h.........l..suGl....uoll.sh...............hssh...l.shh...Gh...uhs..hhs...................hhhls.hG.............................................s.h.sh.t....s...............h....h...uu.s....hltu....ll....h.h....l....ls....h....h.....t....h........h...........h..........l.h.c..h.l.P.....ssl.......p.s....s..l.......s....hsIG.....L.L.h................l......u.....l.....p.......s....s.......u......h......h......h.................................ps..........................h.....s....................s.............p........................h....................h...................h..........u............h...........l......h..............h........l......h....s......l....h...l...thh............................hps..h..h...h..h...h......u...l.L..lu..l.lssh...ll.uh...........h...hG........hl.......s..h.ss............................................................lt.ps.s..h....h....t..h....s..............h..t...h....s.hsh..........................h..s....h...s.....h...l....h...s....h...h.s.h...h...l.ls..hh-................sh..Gsl..h......u..l...u......p...h...ss....h.hpt......................pl.p.+...u...lh.u...Duluohlu.uhh.Gs..sssT.s.a.s....Ess..........u.sluhs...........st..s...hhsus...l.hsl.lh.uh...h.s.hh.u..slhth.lP............s...........s.........l.....hu........u........s........sl.l...........h.h.Ghlh.hsu....lph.l.s.h..s..c..hs...pshs.hh.l.s.ulhls...huhuls.h...hh............................................................................................................................................................................	0	745	1589	2296
+4972	PF04921	XAP5		XAP5, circadian clock regulator	Bateman A	anon	Pfam-B_4702 (release 7.6)	Family	This protein is found in a wide range of eukaryotes. It is a nuclear protein and is suggested to be DNA binding [1,2]. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light [3].	25.00	25.00	29.20	28.20	23.60	23.10	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.56	0.70	-4.80	26	325	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	232	0	217	305	9	237.70	43	71.22	CHANGED	KK+p+pppscLSFssD--E.........................................pppspspttp.cppp..pt.sh.............................p++lsKNPsVsTs.aL.D+sR-ccEpptR-pLRcEaltpQpt...............lKspEItIsFsYaDGosppt.sV+hKKGsoIhtFLp+spc.ht..........tc.....hpEh+psSsDsLMhVKpDlIlPHHYoFY-FIhsK..spGKoG.sLFsFDscc.................................shphhs-hpspc--opssKVV-RpWYERNKHIFPAS+WE......Y-PtKsasp.hhp	....................................................................................................................t.tttththttLSFs.--cctt.....................................................................................................tppptttt.t..........t.....t...................p...............................p+KluKNPs..V-TS..FLPD+-REccEsphR...........EcLRpEW.tpQEplKsEEIpITFS...........YW........D.....GoGHR...+....sVc..............hKKGs......oltpFLp+shchLt..................p-..............FpEL+ss.uV-pLMalKEDLIIPH....HaoFY..-FIlsK...ARGKS.........G..PLF.sFDV+-..........................................D.lRh.l.sDAssEK-ES.......HAGKVV.RpWYE+NKHIFPASRWEs.....YDPpKcac+Ysh.p..........................	0	80	119	170
+4973	PF02625	XdhC_CoxI	DUF182; 	XdhC and CoxI family	Mian N, Bateman A	anon	COG1975	Domain	This domain is often found in association with an NAD-binding region, related to TrkA-N (Pfam:PF02254; personal obs:C. Yeats). XdhC is  believed to be involved in the attachment of molybdenum to Xanthine Dehydrogenase ([1]).	23.80	23.80	23.80	23.90	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.98	0.72	-4.36	129	2575	2009-01-15 18:05:59	2003-04-07 12:59:11	11	15	1586	10	764	2086	952	70.30	30	22.01	CHANGED	tphhppspss....sLuTllpspGSsPRpsGupM..llps-G...p.hhGolu.GGs....lEtplhppApphl..psup.....sphhpash	............t.thhtpspss....sLsTllcspGSsPR.ps.G.ApM.lVpsDG............p...hhGol.u.GGs.................lEtplhpc..A.t.....p.h.l.....tssp......sphhph..h......................	0	243	509	653
+4974	PF03894	XFP		D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	Wood V, Bateman A	anon	Wood V	Family	Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22 [1]. This family is distantly related to transketolases e.g. Pfam:PF02779.	21.20	21.20	21.70	22.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.19	0.71	-4.68	6	1182	2012-10-02 16:07:47	2003-04-07 12:59:11	10	11	939	16	425	1121	49	168.90	47	22.78	CHANGED	spsLGpYlRDll+hN..spsFRlFGPDETtSNRLpusaEVTcRtWhpphhs.s.-...l.sctGpVsEhLSEHpCEGWLEGYLLTGRHGhFuSYEuFl+lVDSMlsQHuKWLchs.p-lsWR+cIuSLNllsoSsVW+QDHNGFoHQDPGhlsslLsKKs-...llRlYLPsDANoLLAVsD+Chpo	................................................p.lGpal+-lhchN.....scs.....FRlFGPDETtSNRLt.ula-sT...s+..tW....t...p.hh.s...t.s-..thhss..sGpVh.E.LSEHt.spGaLE....GYlLTGRHG..hFuoYEuFl+llDSMhsQ....HsKWL.chs.p-.......lsWRpslsSLNhlhTSpVa+QDHNGaoHQDPGhlshlhs.K.p.s-...llRlYLPsDANoLLulh-+sh+....................	0	108	256	360
+4975	PF03469	XH		XH domain	Bateman A	anon	Bateman A	Domain	The XH (rice gene X Homology) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2.  The molecular function of these proteins is unknown.  However these proteins usually contain an XS domain that is also found in the PTGS protein SGS3. This domain contains a conserved glutamate residue that may be functionally important.	22.20	22.20	25.60	33.50	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-4.49	12	174	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	21	0	109	154	0	119.60	41	25.99	CHANGED	KRMGcLs.csFhcAspp+hs.....tp-sp.pAs.lpshWccplp-ssWpPa+h................ssph.tEllsE-DEcL+pLKp-hGE-VYstVppALhEhNEaNsSG+Y.ssELWNa+-sRKATLcEslshhhp...phpphKR+R	..................................................KRMGELD.+sFhpAspp+hs.............tc-sp.pAs.LsShWpppl.+s..ssWHPFKhlh..................................sssptpElls--DpKLppLKp-aG--lapsVtpALhElNEY..........N.s.SG..........RYsssELWNa+EsRKAT.lcEslpalhp...phct.+p+................	1	16	53	82
+4976	PF03468	XS		XS domain	Bateman A	anon	Bateman A	Domain	The XS (rice gene X and SGS3) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2 and SGS3 Swiss:Q9LDX1.  SGS3 is thought to be involved in post-transcriptional gene silencing (PTGS). This domain contains a conserved aspartate residue that may be functionally important. The XS domain has recently been predicted to possess an RRM-like RNA-binding domain [1] by fold recognition.	25.00	25.00	26.60	26.00	24.20	21.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.60	0.71	-4.15	12	211	2012-10-02 20:46:34	2003-04-07 12:59:11	9	16	28	2	131	198	0	117.00	28	20.35	CHANGED	pc-haVWPWhGllsNsssphp.cs+..sG.uusphcpcluc..FsPhcVpsL.Wspp.GasGhuIVcFupsWsGFcsAhth-caF-tptpGK+DWtptp..........t.ptsclaGWsA+t-DYpusshl	.........t.p-hhVWP.hsIlhNsstph..pt..ssp..hGhus....pclhcphsp...Fss.h.+.sp.sl....astp....GHpGhullcFspshsGappAhphccpFptpspG+c-Wtppp......................t..ttptlYGalApt-Dhp............................................	0	16	80	114
+4977	PF04555	XhoI		Restriction endonuclease XhoI	Kerrison ND	anon	DOMO:DM04409;	Family	This family consists of type II restriction enzymes (EC:3.1.21.4) that recognise the double-stranded sequence CTCGAG and cleave after C-1.	25.00	25.00	71.30	35.80	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.14	0.71	-4.90	6	48	2012-10-11 20:44:44	2003-04-07 12:59:11	8	2	42	0	13	50	2	174.20	43	80.90	CHANGED	pKQh-oG+sDpGERuGVTuGKNMDGFlsLlhsllptNGLucA-Ia.ps+shLTLPGYFRPTKLWDlLVlp.....cGpLlAAVELKSQVGPSFGNNFNNRsEEAIGTAaDlWTAaREtAFGcp..RPFlGWLMLVEDsPcS+puVp-sSPHFPVF.EF+GASYlKRY-lLCpKLlhEpLYToAslIsSs+susttGcac-hSp	.........................tsGctDtGpRuuVTuGKphDGFhtLlh-llptsGlscspla..ppthhsLPGYFRPoKpWDLLVlt.....cGpLlAAlEhKSplGsSFGNNFNNRsEEAlGoAhDlaTAa+EstaGpp..tPalGalhllEDsspSppsV+..s.p.p.PH.Fsl..-F................cGsSYhcRYclhCp+LltEpLYssusllhu.t.t...........s.............	0	4	8	12
+4978	PF00193	Xlink		Extracellular link domain	Sonnhammer ELL, Bateman A	anon	Swissprot_feature_table	Domain	\N	21.00	21.00	21.00	21.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.40	0.72	-3.90	12	1651	2012-10-02 16:37:33	2003-04-07 12:59:11	12	106	63	14	677	1338	95	93.40	40	15.67	CHANGED	GhVFahpsss...ploFpEApptChppuAplATstQL.AAacs.Ga-pCsAGWLuDtoVRYPIspPRpsCuGsp...sGVRsh.......Gh..sspppYDsYCa	..............................GhVFahpssp....ploFpEAppsCt.pp.uApl...AossQLhuAact.G.h-p.CsAGWLuDu.oV..R.YP.Isp..P..R...t..tC.uGst............sGVRoh........Gh.....ssp.p.p.a.DsYCa.....................................	1	60	115	287
+4979	PF00867	XPG_I		XPG I-region	Bateman A	anon	Pfam-B_776 (release 3.0)	Family	\N	22.50	22.50	22.50	22.60	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.27	0.72	-3.93	207	2052	2012-10-01 19:52:02	2003-04-07 12:59:11	13	37	569	21	1236	1927	247	87.50	31	14.55	CHANGED	chh.Glsal.AP..hEAEAQsAhLs....ppGh......lsulho-DsDsLlF....Gss....ll+ph.....p.tth...................p.hph...tphhpt....ht..l.sp.cp....hlshslLs.....GsD	...........................t.hhGlsals....A..P..hEA-AQCA.hLt..............cp.Gh......Vsulh..op..DoDhLlF......Gss.....tllp.phs......t.t......................................................................................th.lphhph...p..cl.hpt..........hs...h.sp...pp......hlslslLhGsD..........................................................................................................................	0	441	726	1045
+4980	PF00752	XPG_N		XPG N-terminal domain	Bateman A	anon	Pfam-B_491 (release 2.1)	Family	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.15	0.72	-3.75	10	1710	2012-10-03 20:43:45	2003-04-07 12:59:11	12	35	531	21	1161	1748	220	97.30	29	15.40	CHANGED	MGI+GLhslLpshu....RpsclEsapG..+pLAIDuShaLYQFLpuVRpptGsslps.....sSHLhshFpRhp+lhpaGI+PlaVFDGssP.sLKppslsKRppRRpcs	.....................................MGlp.u.Lhphlpshs...................c..t.h..p..........l....c....p.hp..G.............pp..lAl..............D..u..........sha........l...a..p....h.....h.h..u...s...p...t.p.....u.p.shts.................................sa..l...h..s....hhhR.ht.p.L.l...p.h.sI.+P.l.a...........VF..DG..t..s.s...hKpppht.cRppp+t..t.................................	1	407	670	969
+4981	PF01834	XRCC1_N		XRCC1 N terminal domain	Bateman A	anon	SWISS-PROT	Domain	\N	20.70	20.70	20.80	21.10	18.80	20.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.13	0.71	-4.74	3	182	2012-10-03 19:46:52	2003-04-07 12:59:11	11	9	89	13	107	163	1	131.20	46	23.24	CHANGED	MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGu..TAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVRFHS	.............Ms.lphpcVlSh.SSpD..s.pas.s-NLLp.s.-..s.......+...p.Whss.p.s.t.p.t..p..hpV.LQLE+..t...IptlDlG.NpGuAFlpl.VGpSuhs......-psa.sLLssoohMSPs-S..+sGpN.spVRhF...ssscllpssupcpWDRl+llCoQPas+c.saGLuFl+h+.....................	0	39	46	72
+4983	PF02162	XYPPX	Rhodopsin_C; 	XYPPX repeat (two copies)	Mian N, Bateman A	anon	IPR000216	Repeat	This repeat is found in a wide variety of proteins and generally consists of the motif XYPPX where X can be any amino acid. The family includes annexin VII Swiss:P24639, the carboxy tail of certain rhodopsins Swiss:Q17094. This family also includes plaque matrix proteins, however this motif is embedded in a ten residue repeat in Swiss:Q25460. The molecular function of this repeat is unknown. It is also not clear is all the members of this family share a common evolutionary ancestor due to its short length and biased amino acid composition.	19.00	5.00	19.00	5.00	18.40	4.90	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-6.70	0.72	-4.32	7	228	2009-09-16 16:02:34	2003-04-07 12:59:11	12	13	64	0	33	227	0	14.50	85	15.07	CHANGED	GY....PPQGYPPQuhPPQ	.......uY....PP..Q.G.YP.P..QG.YPPt......	0	20	27	32
+4984	PF04690	YABBY		YABBY protein	Mifsud W	anon	Pfam-B_5698 (release 7.5)	Family	YABBY proteins are a group of plant-specific transcription involved in the specification of abaxial polarity in lateral organs [1,2].	21.00	21.00	21.00	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.27	0.71	-4.01	6	396	2012-10-02 14:16:02	2003-04-07 12:59:11	8	5	153	0	111	371	33	129.80	45	77.58	CHANGED	sslhsso-+lCYVpCsFCsTILAVSVP.sSLaplVTVRCGHCTsLLSlslshts....phLsu.sp................lhpshpspspshs..hhppcssosptss..h........Spsppc-hP+.....sRPPEKRQRVPSAYNRFIKEEIQRIKAsNP-ISHREAFSsAAKNWAHFP+IHFGL	..................................................................................................................................................................CsTlLA..VulP.hpp...lh..phVTV+CGHCsNL...lsht............s.................................................................t........t...t...........t..t.p.....t......................................p.tp........Pc.......hs+P.P..EK+p.RlP...SAYNRFhKEEIQRIKAsN....P-IsHREAFSsAAKNWAp.........................................................	0	20	72	95
+4985	PF03895	YadA_anchor	YadA; YadA_C;	YadA-like C-terminal region	Bateman A, Sandt C	anon	Sandt C	Family	This region represents the C-terminal 120 amino acids of a family of surface-exposed bacterial proteins. YadA, an adhesin from Yersinia, was the first member of this family to be characterised. UspA2 from Moraxella was second. The Eib immunoglobulin-binding proteins from E. coli were third, followed by the DsrA proteins of Haemophilus ducreyi and others. These proteins are homologous at their C-terminal and have predicted signal sequences, but they diverge elsewhere. The C-terminal 9 amino acids, consisting of alternating hydrophobic amino acids ending in F or W, comprise a targeting motif for the outer membrane of the Gram negative cell envelope. This region is important for oligomerisation [1].	21.70	21.70	21.70	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.49	0.72	-3.97	110	2384	2012-10-03 10:38:27	2003-04-07 12:59:11	10	481	927	35	313	2186	103	77.90	30	8.25	CHANGED	hc+csp...uGlAuAhAhuul..Ppssh..sGphsluhGsGsYpGpsAlAlGsuths.ssp..hhh+husu..........sopussususGsuapW	..........................cpchp...uGhAuAhAhuuL....sQs.t......sup..huhGsGsYp...GpsAlAl.Gsuhhs..ssp.......hhh+husoh..........sopu..chususGsuapa...............	0	79	157	241
+4986	PF02699	YajC	DUF219; 	Preprotein translocase subunit	Mian N, Bateman A	anon	COG1862	Family	See [1].	21.00	21.00	21.00	21.50	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.60	0.72	-4.31	176	4454	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	4168	1	876	2416	1646	83.30	32	76.43	CHANGED	sh.hht.ll...h.l.lhhslhYFllIRPQp...K+tK....c+pphlssLp+GDcVlTsGGlhGplspl..s-shlhl-lus.......s..lclclp+su.Isplh	.............s.h...ll..hl.l..lhhslh.Y...Fh..hl.....R.PQ.p.....K+tK.......c+.pp....hh.suLp+GDcVlTtGGlhGpls.cl..........ccs..hlslclss........s...sclphp+s.ulspl...................	1	300	579	737
+4987	PF04073	tRNA_edit	YbaK;	Aminoacyl-tRNA editing domain	Finn RD, Eberhardt R	anon	manual;	Family	This domain is found either on its own or in association with the tRNA synthetase class II core domain (Pfam:PF00587).  It is involved in the tRNA editing of mis-charged tRNAs including Cys-tRNA(Pro), Cys-tRNA(Cys), Ala-tRNA(Pro)[2-5].  The structure of this domain shows a novel fold [1].	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.15	0.71	-4.27	91	9872	2009-01-15 18:05:59	2003-04-07 12:59:11	10	31	4219	22	2098	6622	1977	122.00	22	38.51	CHANGED	p.sstoh.pchuphhs.........hsspph..sKslllcs...................tcsp...hhlslltuspclshpplpphhu....p.clphA..stccltphh.G....hthGslsPhuh.........ttl.plllDpslhshp.p..lhssuspsstplplsstphhch	................................................................ph..tph.sp.h.h.s....................hs......pph...hKoLlhps.................................................scsp.......hllsll..us.p.cls.........p.K.l....tph..h......G..............s..p..c......lphA......s.cc.l...p.p..h..s....G................hhhGuluP.lGh............................pptl..lllDps....ltp..h.....s...p.......lhsuAsp.pshplhhsstphhp.h.......................................................................	0	669	1310	1755
+4988	PF02392	Ycf4		Ycf4	Bashton M, Bateman A	anon	Pfam-B_1026 (release 5.2)	Family	This family consists of hypothetical Ycf4 proteins from various chloroplast genomes.  It has been suggested that Ycf4 is involved in the assembly and/or stability of the photosystem I complex in chloroplasts [1].	25.00	25.00	30.00	29.50	20.20	22.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.08	0.71	-4.96	59	709	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	670	0	68	562	136	177.50	64	96.24	CHANGED	p.sctlhpp.IhGSRRhSNYaWAhllhlGulGFLLsGlSSYltp...............sLlsh.........hsspp.......llFlPQGlVMsFYGluGlhlShYLWhsIhWsVGuGYNc........................................FsKppGh..................................................lpIFRWGFPGKNR+IplpaslcDIpuI+l-l.....pEGlsP+R.....slYL+lKGpp-IPLTRl..GpP.lsLsElEppAAELA+FLpVslEG	.........................................................................R.ScplWIE.IsGSRKhSNFhWAhILFLGSLGFLLVGhSSYLG+.........NLIsl..........hs.S.QQ......................IlFhPQGIV.MuFYGIAGLFISSYLWCTIhWNVGSGYs+........................................FD+K-.GI..................................................VCIFRW..GF..PGhNRRIFLRFhhKDIQSIRlEl.....+E..G.l..s.RR.......lLYMEI+G.pt.s..IP.LTRT..s-N..lT.REIEQKAAELAhFLRVPIE..............	0	16	41	59
+4989	PF01737	Ycf9	YCF9; 	YCF9	Bashton M, Bateman A	anon	Pfam-B_2211 (release 4.1)	Family	This family consists of the hypothetical protein product of the YCF9 gene from chloroplasts and  cyanobacteria. These proteins have no known function.	20.90	20.90	21.70	22.10	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.82	0.72	-4.53	35	1482	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	1444	17	54	419	120	57.60	81	94.87	CHANGED	lFQlslhALlhlSFlLVVGVPVlaASPpsWspoKsllasGuulWluLVhlVGlLNShVs	..........AFQLAVFALIATSSlLLISVPVVF....ASPDGWSSNK..N....VVFSGTSLWIGLVFLVGILNSLIS.........	2	11	34	46
+4990	PF03795	YCII		YCII-related domain	Yeats C	anon	Yeats C, Bateman A	Domain	The majority of proteins in this family consist of a single copy of this domain, though it is also found as a repeat (Swiss:Q9AJZ7). A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function.  This family also now includes the family formerly known as the DGPF domain (COG3795). Although its function is unknown it is found fused to a sigma-70 factor family domain in Swiss:Q9A8M4.  Suggesting that this domain plays a role in transcription initiation (Bateman A per. obs.). This domain is named after the most conserved motif in the alignment.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.94	0.72	-3.79	26	4283	2012-10-02 00:20:33	2003-04-07 12:59:11	9	20	2247	3	1546	3526	595	97.20	23	86.30	CHANGED	Mhasllshspsssh.....ppptshhssHlsaLcpLtppGthlsu................GsthshDG..st.....GGhhlh-ssshspApphupsDPhsps..Gshpth.lh.......pap	...............................................................hahl.h.h...t..p..sst.................ppptshh..s.sHh...shl..p....p...l....t....cpG..p.llsu..............................Gs...h..s...s...s..D....u..........s.....t........t......hG.uhh.l.h..c.sp...o...h....-...p....A...p....thupp...DP..a..s..ts....G...h.h..p.....h.lh.h.............................	1	496	968	1287
+4991	PF02182	SAD_SRA	G9a; YDG_SRA;	SAD/SRA domain	Iyer LM, Aravind L, SMART	anon	Alignment kindly provided by SMART	Domain	The domain goes by several names including SAD [1], SRA [2]  and  YDG [3]. It adopts a beta barrel, modified PUA-like, fold that is  widely present in eukaryotic chromatin proteins and in bacteria [4]. Versions of this domain are known to bind hemi-methylated CpG  dinucleotides and also other 5mC containing dinucleotides. The  domain binds DNA by flipping out the methylated cytosine base from  the DNA double helix [5].The conserved tyrosine and aspartate  residues and a glycine rich patch are critical for recognition of  the flipped out base [4][5]. Mammalian UHRF1 that contains this  domain plays an important role in maintenance of methylation at  CpG dinucleotides by recruiting DNMT1 to hemimethylated sites\	associated with replication forks [2]. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA  methylation to chromatin-protein ubiquitination [4]. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions [4]. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains [6]. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or\	hemi-methylated DNA [4].	20.50	20.50	20.90	21.10	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.06	0.71	-4.92	34	554	2012-10-08 19:26:47	2003-04-07 12:59:11	12	47	169	32	371	572	41	149.00	37	23.53	CHANGED	p+clGslPGlpVGDhFhaRhEhsllGlHtsphuGIDhhpsps..........hAsSIVsSGGY-.DDpDsuDsllYTGpGGps.t.tpp.....pspDQcLpcGNLALtpSh...............cptssVRVlRGhcptpp.........psthYhYDGLYpVpcaWh-pGpsG.htVa+a+LpRh...sGQ	.......................................................................t.phhG.lPG..l.VGshahhRhphs.sGlHtshh....u....G..I.cttssps....................................AhSlVh....u......GG...Yc...DDh.D.pG-.hhYTGpG...Gps.hs.s.s+...................pspDQpL.....p.p..s.NhALthsh................c.pspPVRVlRuh+stpp...................hts.pts..hpYDG..lY+........VhchW...-h.....G..pp..G...hhVa+ahLhR.ss......................................	1	105	204	288
+4992	PF04794	YdjC		YdjC-like protein	Waterfield DI, Finn RD	anon	Pfam-B_5925 (release 7.5)	Family	Family of YdjC-like proteins.  This region is possibly involved in the the cleavage of cellobiose-phosphate [1].	24.00	24.00	24.30	24.20	21.80	23.90	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.77	0.70	-4.92	114	1651	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	1420	8	307	1052	228	240.90	32	92.26	CHANGED	+cLIlsADDFGlotuVNtuIlcuacpGlloSsolMsssPuh.pcAsphs+.p..ts.....tls.lGLHlsLos..GhP.l....h...pthssLlst..............p.GhFhphh........hthh.tphshcpltpElpAQlcpFhs.hGhsssHlDuHpHsH.hhPslhsslhplu.pchsl.....sh.Rh......shp.h................................ht.hstthptphtptGlshss.h...............hhthlhphhpphsp.t..................ssElMs.HPuhh......sst.lhshssh.....stpRtpEhphLsuspltthlppp	....................h.hLIlNADDFGLocuhNhGIlcuhcsGl...loSTohhsNssuh..c....cA.....l...p....Lu+....c....hP.................sLs..lGhHhsLTh..Gc.....P..l............sthPuLsc...............s.G..hhtchh...............p......hh...........p....s.s...l..s.h--l...ppEltuQhp+Fhp..hGt.pPoHlDoH.+H....l....H....hhP.p...lhsllhc.....hA...tchul..........sh..Rh............stpsh................................h.h............lps.spthpstah...sp.slspst.............................hhphLpphhpp.htp............................shElMs.HPAal..............-p..lhp..p.S.ua........shsRhpELclL.sSsplpthltp.p...................................................................................	0	103	183	242
+4993	PF00399	PIR	yeast_PIR; 	Yeast PIR protein repeat	Finn RD	anon	Prosite	Repeat	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.97	0.73	-6.38	0.73	-4.44	17	804	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	57	0	500	869	0	17.80	68	21.99	CHANGED	suAlSQIsDGQlQAToss	...tuAVSQIuDGQIQATTpT......	0	82	223	407
+4994	PF03366	YEATS		YEATS family	Mifsud W	anon	Pfam-B_2273 (release 6.6)	Family	We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity	22.00	22.00	22.10	22.20	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.94	0.72	-4.26	63	798	2009-09-11 12:00:18	2003-04-07 12:59:11	11	14	314	7	532	728	2	83.10	35	19.08	CHANGED	oHpWslal.........cshss.....................c.c..h.uphlcKVpFpLH.toFss.Ph.RslcpP....PFclsEpGWGEFpltIclaahs......ptp.hsl.HpLplpttshp	.......................THpWp..VaV.........+shpp....................................................................................p..c...l.stalcKVhFpLH...Sass.Ph........R.s......l...ccP..........P...FclsEsGWGEF.l.IclaFts......pt+.lslhHpLpLt.pt..s...........................	0	160	267	417
+4995	PF03543	Peptidase_C58	YerHae_surfAg; SurfAg;	Yersinia/Haemophilus virulence surface antigen	Griffiths-Jones SR	anon	PRINTS	Family	\N	22.90	22.90	23.10	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.42	0.71	-4.83	14	182	2012-10-10 12:56:15	2003-04-07 12:59:11	9	21	106	1	40	172	1	170.80	19	15.90	CHANGED	Rsoh...ucaGscsshhhsts..............ts........GlC.uLsAcW....lp.css..spshhspLh.uut.cGp...hphpphhshpphphc..tsttsptph.................phppshLpctGlpPptc.hsht................tsupsshsshlpsIhcsGspphhsh+h....sphuuHslAstsp.spp.lsFFDPNaGEFohsscpp.....tsshapp.hhphpptspphhpllshchp	............................................................................................................................................................................................................................................................................................thp..tpshstllptlh.cssu.pshhs.hh......hptsuHAhAs...h...s...........p...sp....p...h......sFFDPNh..GthpFsstc....pFtta.hpta.htp.h....................t....................................	0	12	23	31
+4996	PF03545	YopE	Yers_vir_YopE; 	Yersinia virulence determinant (YopE)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	26.00	59.50	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.14	0.72	-4.03	8	184	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	159	8	7	96	0	69.90	55	15.70	CHANGED	EpLt+-HspLAoGNGuLRSLsTuLpGIpcGSphpphps.AupLL-psluGIsLQQWGTsGGpAochVsSA	..poLpcNapchASGNGPLRSLhTsLQsLschscscpLp-hsosLhNhplGuhtFSQWGT...sGGsspcalscA.............	0	2	3	4
+4997	PF03887	YfbU		YfbU domain	Bateman A	anon	COG3013	Domain	This presumed domain is about 160 residues long.  It is found in archaebacteria and eubacteria.  In Swiss:Q9EUM2 it is associated with a helix-turn-helix domain. This suggests that this may be a ligand binding domain.	25.00	25.00	31.00	29.70	24.70	24.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.07	0.71	-4.69	4	723	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	710	16	68	261	3	163.40	73	97.45	CHANGED	MEMTssQRLILoNQYpLMshLDs......tNAp+Y+RLpsIlEpGYuLch+ELs.+EFusLsEpEC+pllDIhEMY+AlpsShssLsD......ppslsp+RloFhGFDu..spEu+hlsYVRFlVssE.GcYpcF.tsEHthNSQsPMhsKYpRML....ssW+sCP...+pYHLSssEIppIlNA	..................................................MEMTNAQRLILSNQYKMMTML.DP...........sNAER......YR.RLQ.TIIERGYGL..QM.R.ELD..RE.F.G.ELpE.ETCRTIIDIMEMYHALHVSWoNLpD..........pQuID...E......RRV......TFLGFDA..ATEARY..LGYVRF.MVNl.....E..G..RY...TH..FD..AGT..H.GFNAQTPMWEKYQRML....sVWHACP.........RQY....H.LSANEINQIINA.........................	0	11	24	46
+4998	PF02542	YgbB		YgbB family	Mian N, Bateman A	anon	COGs	Family	The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis) [1].	25.00	25.00	26.20	26.40	24.80	22.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.78	0.71	-4.40	167	3444	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	3393	163	843	2387	2171	155.90	48	76.19	CHANGED	hRlGhGaDVHph........................spG......ct.LhLGGVcIPa..p...........p.GLhGH..SD..uDVllHAlsDALLGAs...uhGDIGpaFPso.Dsp.....aKsssSthLLpcshphlpppGa.plsNlDsTl.luppPKluPa.hstM+pslAphLslshspVslKATTsEpLGFsGRtEGIAAhAls..Llhp.t	..........hRlGpGaDVHph..................................sts.cs...lllGGVcIPa..c......................p..GLluH..SD..uDVhlHAlsDALLGAs...uLGDIGchFPDT.Dsp.....aKGA-SttLLccshc.hlpp........p..G..a.pluNlDsTl.IAQtPKhs.......P+.lspM+tslAcsL.sh.........s.h.sp..VsVKATToE+.L.GFsGRtEGIA.u.pAlsLLhc.t...............	0	298	571	724
+4999	PF02325	YGGT		YGGT family	Bashton M, Bateman A	anon	Pfam-B_983 (release 5.2)	Family	This family consists of a repeat found in conserved hypothetical integral membrane proteins.  The function of this region and the proteins which possess it is unknown.	21.70	21.70	21.70	21.80	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.62	0.72	-4.04	170	4945	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	3567	0	1081	2737	2206	77.70	26	80.00	CHANGED	lphh..lsl.ahhllllps...llSWl........s.....sshs....phlhplT-PlLpPlR.....Rll.P...sl.Gu......l..DhSPllshlllphlphhl.hth	.........................hllplahhllllph...lhSWhss........shp.....sshs.........phlhplo-Pll.t..Pl...R.....Rll..P....sh..Gs.........l..DhS..sllhhllLthlphhlh..h...........................	0	315	665	900
+5000	PF04945	YHS		YHS domain	Bateman A	anon	Bateman A	Domain	This short presumed domain is about 50 amino acid residues long.  It often contains two cysteines that may be functionally important.  This domain is found in copper transporting ATPases, some phenol hydroxylases and in a set of uncharacterised membrane proteins including Swiss:Q9CNI0. This domain is named after three of the most conserved amino acids it contains.  The domain may be metal binding, possibly copper ions. This domain is duplicated in some copper transporting ATPases.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.33	0.72	-4.11	23	1534	2012-10-03 05:12:49	2003-04-07 12:59:11	8	45	1045	41	530	1375	156	45.40	29	10.53	CHANGED	sp-Pssuhpl....sphphcYpG+tYaFsS-sCcttFcp-PEcYhstt	.....................DPVsuhtl.....t..p.ut....h..p.....h.p...YpGp.pY..aFCSppCtppF.ctcPpcYl...........	0	154	311	444
+5001	PF03755	YicC_N	YicC_N-term; 	YicC-like family, N-terminal region 	Finn RD	anon	Pfam-B_3743 (release 7.0)	Family	Family of bacterial proteins. Although poorly characterised, the members of this protein family have been demonstrated to play a role in stationary phase survival [1]. These proteins are  not essential during stationary phase [1].	25.00	25.00	25.10	28.20	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.01	0.71	-4.30	185	2490	2009-09-10 21:41:45	2003-04-07 12:59:11	8	3	2470	0	578	1769	632	155.00	32	53.65	CHANGED	lpSMTGFu+spt......pss.t.............tphshEl+SVNpRaL-lphRLPcthp.slEstlRchlppp.lpRG+V-splphpts..st.sstslp..........l.Npslhpphhpthpp.lppph..th....t.sls....hsp....lLphsuVlp........pp.t-...-t.pth....lhpshcpAlsplhphRpcEGppLtt.	............lpSMTuauRtch.....psp..h................................tphshElRSVNpRaL-hhhRLP.cp.hc.slEsslRctlppp.LsRGKV-splphcts...st..spsplt.........l.NppLscpllpthpp...lptph..st.......spls....hsc......lLc...h.P.GVhs.............sp.t.p-h..-shpt.......lhsulcp...........ALcshhssRppEGptLpt......................	0	207	385	486
+5002	PF03853	YjeF_N		YjeF-related protein N-terminus	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Domain	YjeF-N domain is a novel version of the Rossmann fold with a set of  catalytic residues and structural features that are different from the conventional dehydrogenases [1]. YjeF-N domain is fused to  Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and  FLJ21128) [1], where they may be involved in decapping and catalyze  hydrolytic RNA-processing reactions [1].	24.90	24.90	24.90	25.00	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.04	0.71	-4.65	82	3610	2012-10-10 17:06:42	2003-04-07 12:59:11	10	26	3275	37	1227	3081	755	164.50	29	35.13	CHANGED	shhLMEpAupussc.hlpphh......................sptppllllsGsG......NNGGDGlssARhL..hptGhp.Vpl..........hhhtt.t.phssssppthphhpphs.......hphhp.tsttt...........................sclllDAlhGh.................Ghp.tslcs...t.....htpll.....p..tlNps.......psh.llulDlPSGl..sss.oGps...............s.s.......lp.AchTlohttsK.u	............................................h..tLMcpAGtu....ssp.hhtpth.........................................................................spsppl.lllsGs.G.............NNG..........GDGhlsARh..L...t.t...t..G.hp..Vsl......................hh.ht.s.....p.......hspp.....st.......t.sh.p.t..hp.p...h.u.................st..h...h...s.....t.....h............................................................................s-lllDAlhGh....................................G..lp.....tslcs........s.........hspll.............p..tlNpp.....................................sss..llAlDlP.S..Gl.....suc..oGts.........................uss........................lp.AshTlohtshK.s..................................	0	398	764	1032
+5003	PF03739	YjgP_YjgQ		Predicted permease YjgP/YjgQ family	Bateman A	anon	COG0795	Family	Members of this family are predicted integral membrane proteins of unknown function.\	    They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	27.40	27.40	27.50	28.60	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-5.71	131	5380	2012-10-03 05:18:07	2003-04-07 12:59:11	9	5	2456	0	1233	3656	4737	347.90	20	93.70	CHANGED	RYlhcphlhshlhshhslhhlhhhh.phlphlsph.hpts..ls................hhtllphhh.htlPthlh.hhlP..luhlluslhshupLspssElsulpuuGlShhclhhPhlhhulhlslhshhhsth.lhP...huppphpplhpphhppshtt...........hpsshahptss.................hhlalp..phssssp......hpsl..hlhch...........pp..tshtp..........................................................hl..tAcpuphp.........stthhLpsuphhphstt.....................................................................phphhphpphphphs.hpspphpthttp.......................................................................pphsh.........................tpL...................t.hp.h......pttshs..htphp.hchap+luhPlsslhhslluhs..huhtt..Rtsptts.......hhhulllhhh.aahltthspshutp...shl.ss...hl..usahssl.lhhhlu...hh......lhh+	...............................................................................+Ylh+phhts....hhh.s.hh.hLlsl.h.hh...h.....p......h.l.c....ls...ph...spus......hs....................h.t.h.s..l.t.hhh.hplPphl....hhlPluhhluslhsLup.LspcSElslhpAs.GhShhplhtss..hhhu.lhls.llshhlsta.lsP....hupppt.p......ph...h.s.p.tt.spssht.................th.p..p..u...h..at.p.pss...............................phla.lc....p..l..s.s..stt......................hpsl..hlhpht.......................ps....tpht..s.......................................................................lh..hAcpup.hp......................sphh.hLpsspph....ph..s.st...............................................................................phphpph...pp..h.p..ht...hs....hps..p..tl...s..s.h..t..h.t.....................................................................................................................................................................................................cphsh...........................................tpL............................................................................t..h..tttsps........ssphp..hp.hap+.lshPl.ss.hhhsLluls....h..u..h..ss....Rp.u.phhs............llsull..lh..hh..aahl.tp.hht.s.h.u..tt.....stl..ss................hl...uhhhssh..lhhh..lu..lh.Lh......................................................................................................	0	387	789	1034
+5004	PF02326	YMF19		Plant ATP synthase F0	Bashton M, Bateman A	anon	Pfam-B_984 (release 5.2)	Family	This family corresponds to subunit 8 (YMF19) of the F0 complex of plant and algae mitochondrial F-ATPases (EC:3.6.1.34).	21.80	21.80	21.80	22.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.24	0.72	-3.41	23	331	2012-10-02 21:03:42	2003-04-07 12:59:11	10	3	267	0	25	589	973	79.00	31	61.04	CHANGED	PQLDphTahoQFFWLslh......FhshYl..hlh......pphLPtls+ILKlRpphhpp.h...splppppp...httcshltcs.h..................hshl.pol	...........PQLD..ph..T..YaoQaFWhhlh......hhshYl..hls..........t.hlstIsclLKlRpph.l.ppp.........................................................h....................................................................................................................	0	9	15	18
+5005	PF01514	YscJ_FliF		Secretory protein of YscJ/FliF family	Bateman A	anon	Pfam-B_736 (release 4.0)	Family	This family includes proteins that are related to the YscJ lipoprotein, and the amino terminus of FliF, the flageller M-ring protein.  The members of the YscJ family are thought to be involved in secretion of several proteins.\	    The FliF protein ring is thought to be part of the export apparatus for flageller proteins, based on the similarity to YscJ proteins [2].	23.90	23.90	24.10	24.00	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.24	0.70	-11.00	0.70	-5.17	21	3384	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	2156	28	653	2296	453	200.40	28	45.09	CHANGED	hpthpth.........hslhhhl..hlhsuspt.......tpLYsuLspp-uNcllshLtptsIsscppssssu....lhVspsphspAhhlLsspGL.P+pshsshtplFspsuLlsoshpEps+hhhAlppELucTlspIcGVhsARVHlsLPcc.sshscsspPsSASVhl+hpsshsls.s.lssI+pLVssSlsuLsh.....-ploVl.sstt.....spsspsh	............................................................hhh..............h....hhlsl..h..lhl.....hhh...s...t.ss..p...........hpsL.as.s..L..spp-..u...s..pllshLppt.sIs.achp...s........s.........us........s........lhV.sts.c.ht.p.....s.+h.h.Lsp.pG.L..P..p...s...s.t.s.uh....plhs..p.p.sh.u.sSphtE..psp....hppAlEtELs+.oI.p.sl.ss..VpsARVH.l........u...hPcp...sha.....s...c....p..p..p...s...s..oA.SVhlp.h.p.s...u.ts...Ls...tp.lsuI...hpLVuuuVsuLs.......psVollDpsu.phls...t.....stt..................................................	0	201	389	515
+5006	PF04650	YSIRK_signal		YSIRK type signal peptide	Bateman A	anon	Pfam-B_3441 (release 7.5)	Motif	Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology.  There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.77	0.72	-6.95	0.72	-4.37	66	6800	2009-01-15 18:05:59	2003-04-07 12:59:11	12	627	727	0	247	4894	0	26.50	41	2.13	CHANGED	tp+pp+YSIRKhs.lGsuSVhlusslhh	........p+pp+aSIRKho.lGsuSVlluohlhh......	1	29	57	149
+5007	PF02295	z-alpha		Adenosine deaminase z-alpha domain	Mian N, Bateman A	anon	Pfam-B_11136 (release 5.2)	Domain	This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric  hindrance [1].  	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.91	0.72	-4.20	8	330	2012-10-04 14:01:12	2003-04-07 12:59:11	12	22	95	39	79	339	3	62.40	29	16.39	CHANGED	stss.cpplLsaLcplG.spssTAhALshplsh.K+-IN+hLYsLp+pGclp+psGsPPlWplssts	....................tp.pphlhphLpphu.tpsspslshshtLs.h..K+-lN+sLYcLp+pupV.h.p..ps.s.p.PPhWhls...t..........	0	14	20	32
+5008	PF01559	Zein		Zein seed storage protein	Bateman A	anon	Pfam-B_181 (release 4.0)	Family	Zeins are seed storage proteins. They are unusually rich in glutamine, proline, alanine, and leucine residues and their sequences show a series of tandem repeats [1].	24.60	24.60	26.10	24.60	21.30	23.80	hmmbuild  --amino -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.11	0.70	-5.12	9	325	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	7	0	22	337	0	134.90	41	97.79	CHANGED	IIPQCSLAP.uAIIPQFLPPVTSMGFEHPAVQAYRLQQALAASlLQQPIAQLQQQSLAHLTIQTIAsQQ.......QQQQ.FLPALSpLAssNPVAYLQQQLLASNPLALANssAYQQQQQLQQFLPALSQLAMVNPAAYLQQQQLLSSSPLAVuNAsTYLQQQLLQQIVPALo.QLAVANPsAYLQQ..LLPFNQLsVoNSAAYLQQRQQL..lNPLsVANPLVAAFLQQQ..QLLPYNQhSLMNPALShQQPIVGGAIF	.......................................................................................................................................................................................................................................................................................................hp.QlshhN.....suY..QQ....hLP..FsQLss.s..ssuaLpQ.Q......h......s.....ssh......p..h....h................................	0	0	22	22
+5009	PF01754	zf-A20		A20-like zinc finger	SMART	anon	SMART	Family	The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain [5-6]. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.	21.60	21.60	22.20	21.60	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-6.89	0.72	-4.35	53	982	2009-09-21 14:31:35	2003-04-07 12:59:11	11	20	182	26	514	896	0	25.10	43	10.59	CHANGED	shhC.psGCGFaGsstspshCS+Ca+	.......hhC.tsuCGFaGsstspshCScCa+...	0	109	204	332
+5010	PF01428	zf-AN1		AN1-like Zinc finger	Bateman A, SMART	anon	SMART	Family	Zinc finger at the C-terminus of An1 Swiss:Q91889, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.	23.60	23.60	23.60	23.70	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.21	0.72	-4.08	181	1823	2009-01-15 18:05:59	2003-04-07 12:59:11	11	43	398	8	1124	1782	126	42.70	34	20.23	CHANGED	Csh..Cpptsh..h....shp...Cp.CstpFCtpHRh.-sHsC........sthhptps	.........................Csh..Ccppsh....h....shp.......Cc..CsphFC.t.pH.Rh.s......-sHsC.shshpt..s.......................	0	351	592	859
+5011	PF00096	zf-C2H2		Zinc finger, C2H2 type	Bateman A, Boehm S, Sonnhammer ELL, Gago F	anon	Boehm S	Domain	The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].	20.80	14.10	20.80	14.10	20.70	14.00	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.01	0.73	-7.19	0.73	-3.30	194	44392	2012-10-03 11:22:52	2003-04-07 12:59:11	21	6603	1241	52	26561	243772	896	23.40	34	6.87	CHANGED	apCp...tCs...csFsppspLppHhpp...H	..............apCp.........tCu........KsF.s.p..p.s..s.L..ppHhch..H..............	0	6055	9206	17573
+5012	PF00105	zf-C4		Zinc finger, C4 type (two domains)	Sonnhammer ELL	anon	Prosite	Domain	In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.	21.10	18.00	21.10	18.90	21.00	17.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.87	0.72	-3.74	26	7638	2009-11-03 19:32:23	2003-04-07 12:59:11	13	91	562	105	3458	7043	2	66.30	47	14.76	CHANGED	phCtVCGD+ASGhHYGlhoCEGCKGFF+Rolppshp..YsCttsps..ChIDKppRspCQhCRh+KClpVGMs+	........................t.hChVC.G...D...c....u..o....G..h.....H.YG.......l.h...............o..CE.......G.........C.....K..............u.FF.....+.........R...........o.l....p...........p.........p.hp...........Y.p.....C....t...t.....s.......p...s.............C................I......s...........+................p.........p....R.....p..........p........Cp.h..CRh.pKClp.s.GMp........................................	0	862	1129	2576
+5013	PF01396	zf-C4_Topoisom		Topoisomerase DNA binding C4 zinc finger	Bateman A	anon	Pfam-B_1854 (release 3.0)	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.19	0.72	-4.45	27	10157	2012-10-03 10:42:43	2003-04-07 12:59:11	14	102	3740	0	1974	7084	1633	39.50	35	11.65	CHANGED	stpCPcCG.upllh+pu+hG...pFlGCoNaPcCcasp.hppp	.................pCP..p..C......G....u.....p.....h.ll......+.p....u.....+hG.........hF.h..uCos..Y.....P....c....C.chsp.h...t................	0	613	1165	1614
+5014	PF02928	zf-C5HC2		C5HC2 zinc finger	Bateman A	anon	[1]	Domain	Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji [1]. This domain may have a DNA binding function.	21.00	21.00	22.10	21.50	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.10	0.72	-3.90	52	591	2009-01-15 18:05:59	2003-04-07 12:59:11	11	55	220	0	364	545	6	54.70	37	4.03	CHANGED	CphC+shsaLStlsCp.sps.schsCLpHhpplC.sC...sssp...........psLhYRash--Lpshl	.........CthC+ssCaLSulsCp.s.ps..s.......pllCLpHs..pcLC...sC...sspc...........ppL.hYRYol--L.shh...........	0	88	162	259
+5015	PF01807	zf-CHC2		CHC2 zinc finger	Bateman A, Griffiths-Jones SR	anon	Pfam-B_755 (release 4.2)	Domain	This domain is principally involved in DNA binding in DNA primases.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.25	0.72	-4.44	19	5345	2012-10-03 10:42:43	2003-04-07 12:59:11	15	58	4422	3	1153	4188	2239	96.10	38	16.85	CHANGED	lspphIspltpphDIV-llupY.VpLKKpGcs.ahuhCPFHsEKTPSFoVsspKpaY+CFGCGsuGssIsFlMchcplsFs-AlccLActhslclshpps	........................................h.spphIpplhs..p...s..s..I.l.-lls...p..h....V.....p....L....+....K....p.....G.p.....s.....a........h.u.h..C..P...F...H...s.....E...K.....T..P...S..Fs..V....s.....s...........p......K.....p....h...aHCF...G...C...G....t.u.G...s.s.lsF......l.hc.h.....-......p.l.......s.F.s..E.AVcpLApphslpls...t..................................	0	413	797	991
+5016	PF05207	zf-CSL		CSL zinc finger	Wood V, Bateman A, Mistry J	anon	Pfam-B_12353 (release 7.7)	Domain	This is a zinc binding motif which contains four cysteine residues which chelate zinc [1].  This domain is often found associated with a Pfam:PF00226 domain.  This domain is named after the conserved motif of the final cysteine.	29.20	29.20	29.20	29.60	28.50	29.10	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.31	0.72	-4.46	63	560	2009-09-14 12:18:22	2003-04-07 12:59:11	8	13	302	5	396	552	5	58.50	38	39.82	CHANGED	--lcl-Dhpa.cp...ppp...h..ahasC..CGDt..Fplotp-......................Lpcs..............-.lspCsoCSLhl+Vlas	....................................-clclEDhpa...-p.......spp.....h.....ahYPC..CGDp..Fploc--.......................................Lcps..........................-plss..CsoCSLhl+Vla....................	0	126	209	321
+5017	PF05180	zf-DNL		DNL zinc finger	Wood V, Bateman A	anon	Pfam-B_9925 (release 7.7)	Domain	The domain is named after a short C-terminal motif of D(N/H)L. This domain is a novel zinc-finger protein essential for protein  import into mitochondria [1].	20.90	20.90	21.20	21.70	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.42	0.72	-4.26	36	372	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	277	1	263	362	4	65.70	43	36.22	CHANGED	h.lsFTC........phCspRSs+phSKpAYp+GsVllpCPuCcN+HLIADpLuhFt.D..pch.....slE-lltpcG-pl	..............................h.lsFTC..........psC.s..pR.Ss.+phSKpAYc+Gs.VllpCsGCpsc.......HlIADpLshFp...-.......tch...........slE-lltt+Gcp........................	0	85	151	222
+5018	PF02701	zf-Dof		Dof domain, zinc finger	Mian N, Bateman A	anon	Pfam-B_1250 (release 5.5)	Family	The Dof domain is a zinc finger DNA-binding domain, that shows resemblance to the Cys2 zinc finger [1]. 	26.60	26.60	27.00	27.10	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.27	0.72	-4.05	12	858	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	68	0	436	848	5	61.10	65	20.51	CHANGED	pssphltCPRCcSssTKFCYYNNYslsQPRaFCKsCRRYWTcGGoLRNVPVGGGsRKsKpsuo	...........p..pphLpCPR.Cs.S.h.s.TKFCYYNNY....slo....QPRHFCKs..C+RYWTcGGoLRNV...PVGG..GsRKsKpt..t..................	0	71	291	367
+5019	PF04770	ZF-HD_dimer		ZF-HD protein dimerisation region	Kerrison ND	anon	Pfam-B_2002 (release 7.6)	Family	This family of proteins has are plant transcription factors, and have been  named ZF-HD for zinc finger homeodomain proteins, on the basis of  similarity to proteins of known structure [1].  This region is thought to  be involved in the formation of homo and heterodimers, and may form a zinc finger [1].	19.40	19.40	22.20	22.50	18.80	18.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.51	0.72	-3.91	36	349	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	39	0	213	332	0	58.20	56	24.97	CHANGED	sssspY+ECLKNHAAulGGHAlDGCGEFMsu.utp.ss........ssuL+CAACGCHRNFHR+Espsss	................t...s+Y+EChKNHAAulGGa.AlDGCGEFMsu.Gp-...Go.....................suL+CAACGCHRNFHR+Esp..s.............	0	27	141	179
+5020	PF01422	zf-NF-X1		NF-X1 type zinc finger	Bateman A	anon	Bateman A	Family	This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA [1].	21.30	21.30	21.50	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.30	0.72	-3.96	21	469	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	145	0	254	497	0	21.40	56	4.43	CHANGED	CG.....HpCpphCH..GsC.s....C.p	...........CG............HpCpphCHt.GsCtP.....C.p..........	0	57	98	163
+5021	PF00645	zf-PARP		Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region	Bateman A	anon	Prosite	Domain	Poly(ADP-ribose) polymerase is an important regulatory component of the cellular response to DNA damage. The amino-terminal region of Poly(ADP-ribose) polymerase consists of two PARP-type zinc fingers.  This region acts as a DNA nick sensor.	21.10	21.10	21.50	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.07	0.72	-3.74	54	620	2009-09-11 00:32:30	2003-04-07 12:59:11	13	68	222	32	406	653	6	80.80	30	14.72	CHANGED	EYAKSuRusC+...pCp...pcItKsplRluphlpssth..........hthhpWaHhsChhtcthp.............tshsslp..Gacp.....Lp...-DQcc....l+ctlp	...................................EYAKouRu.sCK....tCp....ppI...t.Ksp..l.Rluth....s.ssht.................uth.pWaH..h..sChhppttph.........................tshsplc.Gapp.....Lp...-Dpcplpctl.t................................................	0	154	220	329
+5022	PF00641	zf-RanBP		Zn-finger in Ran binding protein and others	Bateman A	anon	Prosite	Domain	\N	23.80	17.00	23.80	17.00	23.70	16.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.50	0.72	-4.84	24	3729	2012-10-03 10:42:43	2003-04-07 12:59:11	13	208	314	29	2137	3538	147	29.60	34	7.44	CHANGED	+tG.pWpC..ssCs.hpNpspss+ChtCpus+.s	............u.sWpC.......ss..Cs.hhNh.spp..s.p.C...t..Cpss+............	0	545	976	1540
+5023	PF02135	zf-TAZ		TAZ zinc finger	De Guzman R, Mian N, Bateman A	anon	IPR000197	Family	The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1.  The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.	19.00	19.00	19.00	19.10	18.60	18.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.14	0.72	-10.63	0.72	-3.97	22	729	2009-01-15 18:05:59	2003-04-07 12:59:11	11	57	134	16	456	660	8	76.50	38	8.52	CHANGED	hplpchL.hLlHApp..Cps.t...............spCsh..pCtph+pllpHhpsCpttp...hstChts+pllp....Hh+pCpctc.CsVshs	...............................t..lQppl.hLlHApp.....Cpp..................................ssC.s.l....PpCppMK....pllpHh.ppC............p....t...pp...................sut..Cs.s+p..llu............Hh...KpC....p...c......p....c....CsVshs.................	0	164	240	349
+5024	PF02953	zf-Tim10_DDP		Tim10/DDP family zinc finger	Bateman A	anon	Pfam-B_1207 (release 6.4)	Domain	Putative zinc binding domain with four conserved cysteine residues.  This domain is found in the human disease protein Swiss:O60220.  Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import [1].\	   Members of this family seem to be localised to the mitochondrial intermembrane space [2].	19.80	19.80	20.20	20.10	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.70	0.72	-4.68	113	1455	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	335	20	1012	1331	11	64.70	25	64.21	CHANGED	.phlttEtphtphpphhs...clscpCacKClsp.......ssupLs....psEpsClspCss+ah-ssttlupphppp	.............................h.tptphpph...t..phhs........pls..ct..CacKC.lss..........hssspLs..........spE.psClsp....Css+ahcssphlspphtp.................	0	311	524	818
+5025	PF02176	zf-TRAF		TRAF-type zinc finger	Mian N, Bateman A	anon	IPR001293	Family	\N	22.80	20.90	22.80	20.90	22.70	20.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.45	0.72	-3.59	10	1745	2012-10-02 00:06:50	2003-04-07 12:59:11	13	81	229	11	1175	1418	42	55.90	26	18.63	CHANGED	Hhps.CPhhslsCsstCst+hl.Rcclp-HlctsCspsclsCpF...GCppphptpsLQcH	......................H.tp.C..h.h...ltC..s.....p...t..s..s.p.p.............l....Rp.....pl.pp..Hh.p............pC.s.p......p............h..p.Cpa..................Cpt..p.h....tpphtpH.............	0	568	732	927
+5026	PF02207	zf-UBR	zf-UBR1; 	Putative zinc finger in N-recognin (UBR box)	SMART	anon	Alignment kindly provided by SMART	Family	This region is found in E3 ubiquitin ligases that recognise N-recognins [1].	21.20	21.20	21.20	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.67	0.72	-4.26	99	1193	2009-09-11 04:39:18	2003-04-07 12:59:11	15	56	293	33	848	1163	4	71.30	30	4.46	CHANGED	phCst.htpt..........pshYpChsCsh........sss....sslChsCashssHp..sHchhhhhsp...tsuhCDCG...ssps.......hp...p....Cph+..p	......................p.hCshshtst..........pshYpC.p..TCsh...............ss.s.........s.slChsC.tts.sHp..sHchphhhos...tshhC..........DCGssph......hp....t.......Cp...t........................	0	316	455	695
+5027	PF03470	zf-XS		XS zinc finger domain	Bateman A	anon	Bateman A	Domain	This domain is a putative nucleic acid binding zinc finger found in proteins that also contain an XS domain.	21.00	21.00	21.50	21.90	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.30	0.72	-3.91	12	126	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	22	0	79	124	0	41.60	45	7.07	CHANGED	CPaC.scKKps..Yp.hpsLLpHAsGlGtustp...u+cKApHhALA	CPaCssc+..cps..Yp.hp-LLpHAsGl.Gtustp.+.u+c+A.sHhALA........	0	11	47	67
+5028	PF01258	zf-dskA_traR	zf_dskA_traR; 	Prokaryotic dksA/traR C4-type zinc finger	Finn RD, Bateman A	anon	Prosite	Family	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.99	0.72	-4.19	241	5127	2012-10-03 10:42:43	2003-04-07 12:59:11	12	11	2754	13	1228	3101	1711	36.80	38	28.18	CHANGED	sshuh..Cp..pCG-tIsttR.hphh..s.ssthClsC...pppt-p	................paGh....C-..pCGp.IshtR.LcAh..P.ssphClcC.......pphtE..............	0	410	784	1014
+5029	PF04071	zf-like	DUF379; zf_like; 	Cysteine-rich small domain	Kerrison ND, Finn RD	anon	COG2158	Family	Probable metal-binding domain.	19.60	19.60	20.60	21.00	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.70	0.72	-4.28	24	168	2009-09-10 20:56:46	2003-04-07 12:59:11	7	9	158	0	79	154	6	85.40	33	50.46	CHANGED	cphphhh..h...s.pcsCEYYPCH.apsQ...sChaCYCPhYPCtDpph.GcalpspsG.t.tlWuCpsCpllHcs-ssstllcphpphscphp....shc	..........t...aphasscsCcaaPCH..hpsp....NCLFCYCPLYsht-pss.G..p..ahh..sc.sG......lKsCosCtlPHct-s.hshlhpphtphht........pt............................	0	23	57	68
+5030	PF04354	ZipA_C		ZipA, C-terminal FtsZ-binding domain	Mifsud W	anon	COG3115	Domain	This family represents the ZipA C-terminal domain. ZipA is involved in septum formation in bacterial cell division. Its C-terminal domain binds FtsZ, a major component of the bacterial septal ring. The structure of this domain is an alpha-beta fold with three alpha helices and a beta sheet of six antiparallel beta strands. The major loops protruding from the beta sheet surface are thought to form a binding site for FtsZ [1].	20.60	20.60	20.90	20.70	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.44	0.71	-4.67	59	1250	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1235	12	217	840	288	128.60	41	38.95	CHANGED	sppllllp.VhAppspthpGspLlpsl.shGhca.G-MsIFHRHtc......sususVlFSlANhhpPG..sF-.-s.hppFsTsGlshFMpLPs.u.suhpsFchMlpsApplAccL.sG.lLD-pRshhTt........pshcpa+p+l	...........................................................p.ptVIlhp.VsA+p.s.ptlsGphLlsulppsGFhF.G.-.MsI.FHR.H.hs......sGsGssLFSlANMspPG..oF.D.s.....-....hs..-Fo..T.sGlolFMp...lPuhG....-..sh..........pNF+LM.LpoApclA--l.GGsVLDDpRchhTsQpLccYpsp....................	0	42	104	163
+5031	PF00172	Zn_clus		Fungal Zn(2)-Cys(6) binuclear cluster domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.94	0.72	-4.04	29	13354	2009-09-16 22:05:51	2003-04-07 12:59:11	13	237	239	36	10553	14063	8	39.10	32	5.66	CHANGED	puCppCRp+KlKCct...ppP........CtpChpts..hcCp.hspppppt	................uCtpCR..p....R..Kl..K....C..Dt...............ppP..............................C..sp..Ct.cts......hp..Ct..ht......t...................	0	1813	5198	8893
+5032	PF00882	Zn_dep_PLPC		Zinc dependent phospholipase C	Bateman A	anon	Pfam-B_1401 (release 3.0)	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.45	0.71	-4.59	152	1056	2012-10-01 21:01:47	2003-04-07 12:59:11	13	12	595	25	245	1095	36	178.70	16	56.63	CHANGED	sHhtl.spsht.....hl...h.t.................h.hthsshhhGuhhPDh........h...........................tths+p...................hhh......h.ptshltthspth.t............................hhhhuhhlGhhoHhlsDhhs..H...........................thhttp..hhpHsthEhthphhh..............................................h..httt.thth........h.thltpthtthhtthhht	.......................................................Hhhlspphhp.........hh..t...................ltp.hpth.hG..shhPDh........h.........................th......hhpscp.....................................pth....pphtcah..ttshpphpp...................................................tphppts.ah.LGhhhHahsDhsp.......H.................................................h.phhshs....ttHsthEphh-phh.................................h..........................................th.......................................................................................................................	2	119	194	221
+5033	PF04228	Zn_peptidase		Putative neutral zinc metallopeptidase	Kerrison ND, Finn RD	anon	COG2321	Family	Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	20.10	20.10	20.10	20.20	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.06	0.70	-5.18	8	1671	2012-10-03 04:41:15	2003-04-07 12:59:11	8	2	1494	0	416	1190	90	272.60	44	93.05	CHANGED	McWcutRpSsNlEDRRupsGGuu.hGGGG........hh.thGGtsGlllllllLlGhhaGlDlosllG..........Gpssuss.ss.Qsstspuss...tpcEtspFssslLAsTEDTWsplFp.ctGppYppPsLVLaSpss+SACGtApSAsGPFYCPuDpKVYLDhoFas-hpp+hGAuGDFAtAYVIAHEVGHHVQNLLGIhsKlcptpp.ssocApANpLSVRlELQADCFAGVWAppsptct.h.LEpGDlEEAhNAApAIGDDTLQ+pupGhVVPDSFTHGTSpQRhpWFcRGapSGcPupCDTF	......................................................................................................................................Mchps..+p.Ss.N..l-Dp.R...ss........G.G.....su................h.hh...u...G..h....h....G.l.h....h.l....l.l.l.l....l.u...h.h.....h....G........l...D........s...s..l.hs...............................G.p.s...st.p.............p...s...s..t....s..h.sss....................p-cssc.F...s..s....s...l...L...u...s...T...E...DsWs.p...hF.p...p..h...G.....p..s..Y.p.p.P..+.....L.V....h..a..p....G...t...s...p........T......u......C.G...s...u..p...S.....s..h....G.......P...F...YC.....P.u..Dp..p...........VYl....D....l.S.F.a.c.-.h..c.s.....+h....G..............A......s.....G..............D...F...A.......QuY.....V..I...AHEVGHHVQ...pLL.GI.s.+.lpph..pp...ph....o..p.s..p..sN..pL..SV..RhELQADCa..AG.V...W....u+ph.......p.......p.......p..........s.......l........L....E....s...G.D.l..EE..A.LsAApA.IGDD..cLQpp.up..GpVV.PDS.FTHGTSpQRhpWFp+Gac.o.G....-..spCsTF..................................................................	0	123	271	358
+5034	PF04298	Zn_peptidase_2		Putative neutral zinc metallopeptidase	Kerrison ND, Finn RD	anon	COG2738	Family	Zinc metallopeptidase zinc binding regions have been predicted in some  family members by a pattern match (Prosite:PS00142).	20.20	20.20	20.50	35.60	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.47	0.70	-4.99	75	1143	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1121	0	242	727	493	219.40	45	96.58	CHANGED	sshhlll.lsshlluhhAQh+VpSsFpKYScVpspsGhTGA-lA+clLcssGlh.D..VpVcpls.GpLTDHYDPpsKslRLS-sVYsusSlAAluVAAHEsGHAlQatpsYusLplRsslVPlsshuSsluhhlllhGllh........tstsLlhlGIlLFusuVLFpllTLPVEFsAS.pRAlthLpspG..llss.cEhp.uu+cVLsAAAhTYVAAAlsulhpLLhh...lhlhtsp	.............................................................s..hhlhhlhhhl.lshhAQh+VpSsapKYSpV..psssGh..TGt-lAccILcssGlh..DVpVpp.ss..GpLTDHYDPpsKsVpLSpssYpusSlAusuVAAHEsGHAlQct.puYs.Lc.hRsuLVPVsNhGSsl..u...a.hll....hl..Gllh...........hsssllhlGIl.......Lh.u..huVL..F.plVTLPV...EFsAS.pRAhphLpstG..llsp..cE.ht.tA+KVLsAAAhTYVAAuhsulhpLlRl.lllhtt.p.....................	2	113	190	223
+5035	PF03854	zf-P11	ZnF_P11; 	P-11 zinc finger	Griffiths-Jones SR	anon	PRODOM	Family	\N	25.60	25.60	26.20	66.20	25.20	25.50	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.96	0.72	-4.49	3	115	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	38	1	0	114	0	49.90	61	52.85	CHANGED	GPhNCKSCWFcsKuLVcCsDHYLCL+CLsLLLSVS-RCPICKpPLPTKLR	G.hNCKSCWFts+uLlcCsDHYLCL+CLslhLssSDhCsICtcPLPT+l..	0	0	0	0
+5036	PF03367	zf-ZPR1	ZPR1; 	ZPR1 zinc-finger domain	Mifsud W	anon	Pfam-B_1372 (release 6.6)	Family	The zinc-finger protein ZPR1 is ubiquitous among eukaryotes. It is indeed known to be an essential protein in yeast. In quiescent cells, ZPR1 is localised to the cytoplasm. But in proliferating cells treated with EGF or with other mitogens, ZPR1 accumulates in the nucleolus. ZPR1 interacts with the cytoplasmic domain of the inactive EGF receptor (EGFR) and is thought to inhibit the basal protein tyrosine kinase activity of EGFR. This interaction is disrupted when cells are treated with EGF, though by themselves, inactive EGFRs are not sufficient to sequester ZPR1 to the cytoplasm [1,2,3]. Upon stimulation by EGF, ZPR1 directly binds the eukaryotic translation elongation factor-1alpha (eEF-1alpha) to form ZPR1/eEF-1alpha complexes [1]. These move into the nucleus, localising particularly at the nucleolus. Indeed, the interaction between ZPR1 and eEF-1alpha has been shown to be essential for normal cellular proliferation [1], and ZPR1 is thought to be involved in pre-ribosomal RNA expression [2]. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A but does not directly influence the kinetics of nucleotide exchange or GTP hydrolysis [4]. The alignment for this family shows a domain of which there are two copies in ZPR1 proteins. This family also includes several hypothetical archaeal proteins (from both Crenarchaeota and Euryarchaeota), which only contain one copy of the aligned region. This similarity between ZPR1 and archaeal proteins was not previously noted.	20.30	20.30	20.30	20.40	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.00	0.71	-5.08	14	842	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	422	2	572	806	66	154.90	34	67.74	CHANGED	cssCPsCstpspT+h..hhssIPaF+EVllMSh.C-+CGa+ssElpsuutlpspG.Rhpl+lps.cDLsRcVlKS-ouolpIPELslEI.Ps.sttGplTTlEGlLpcshctLpps....tpcutcspptpphpcalp+lcpl...hpspp.hTlIl-DPhGNSalps	......................p.o.C.sCt.p.s.s.p.T.+h.......hhspI.....PaF+ElllhohpC-pCGa+...ssElpsuGtlp............pGh+hsLc.l...p...s......p.....D....LsRp.l.lK...........S-ouslp............I..P.EL....-lEl.Ps.s...tG...phTTl..EGlLpphh-tLpppt..................ht..........c......s..s...........sp..........ttp+hppFhp..+.....Lcph....................h.p...s...c..h...s...aTlll-DPhGNSalp...........................................................................	0	199	320	463
+5037	PF00791	ZU5		ZU5 domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.07	0.72	-4.35	30	1349	2009-09-12 23:26:40	2003-04-07 12:59:11	15	421	101	19	679	1023	3	99.30	30	7.68	CHANGED	suhpspGhhsstGGpLp.sspoGVSLlIPsGAIspGpphEhYlslsc....cpst.................................hPP..hcpup.oLLSPlVsCGPsGshhhpPVhLplPHCAshs.t..-c...hhlpLKopssp	...................................................................hsphhhsspGGphp..h.p..s..GlpllIPstshs.t.s.p.php...ht....lshhp....c.ss..................................................................................PP....ht.cs.EsL..hS.ll...ph.G.....PsG...h..p.........F...h..p............PVhlplP..Hhushp..t...-p.....lhL+pps..p......................................................................................................................	0	300	340	472
+5038	PF00569	ZZ		Zinc finger, ZZ type	SMART	anon	Alignment kindly provided by SMART	Domain	Zinc finger present in dystrophin, CBP/p300.  ZZ in dystrophin binds calmodulin.  Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.72	0.72	-4.42	10	2746	2012-10-02 13:15:50	2003-04-07 12:59:11	12	308	324	4	1705	2687	25	44.50	31	4.44	CHANGED	s+cpscCNhCppsshlGhRY+sL+s.sYDLCpuCFhoG+su+sH+M	..................h...thpCs..t..C......p...p........s....l..h.....G...h...R.a.+C..t..p..C...........s.....a..DLCpsC....a...t.....p.....t...htt.p....................	0	562	809	1281
+5039	PF04358	DsrC		DsrC like protein	Kerrison ND	anon	COG2920	Family	Family member Swiss:P45573 has been observed to co-purify with  Desulfovibrio vulgaris dissimilatory sulfite reductase [1], and many  members of this family are annotated as the third (gamma) subunit of  dissimilatory sulphite reductase. However, this protein appears to be only loosely associated to the  sulfite reductase, which suggests that DsrC may not be an integral part of the dissimilatory sulphite reductase.  Members of this family are found in organisms such as E. coli and H. influenzae which do not contain  dissimilatory sulphite reductases but can synthesise assimilatory sirohaem  sulphite and nitrite reductases.  It is speculated that DsrC may be  involved in the assembly, folding or stabilisation of sirohaem proteins [2].  The strictly conserved cysteine in the C terminus suggests that DsrC may have a catalytic function in the metabolism of sulphur compounds [3].	24.90	24.90	25.40	38.20	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.35	0.72	-3.81	87	1238	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1122	8	258	699	173	107.10	55	95.17	CHANGED	tlphsGpplcsDc-GaLhs.hs-Wsc-lAphlApp.E.........sIs.....LT-sHWcVlpalRcaYtcap...hu.P.slRhLsKshutchG.cKus.oca...LYpLFP.tGPAKpAsKlAGLPKPssCl	..............h...apG+pI-TDs-GYLp-..spWoEslAhhlAcp.E.........GIp...Los-HWEVl+FVR-.FYhE.F.s..TS....P..AIRMLVKAhup.KaGp.EKGN.S+Y...LY+LFP.cG.PA.KQATKIAGLPKPsKCl................	0	84	153	208
+5041	PF04252	RNA_Me_trans	DUF431; 	Predicted SAM-dependent RNA methyltransferase	Kerrison ND, Finn RD	anon	COG2428	Family	This family of proteins are predicted to be alpha/beta-knot SAM-dependent RNA methyltransferases [1].	20.10	20.10	20.20	21.90	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.15	0.71	-4.91	3	169	2012-10-01 22:53:19	2003-04-07 12:59:11	8	4	163	0	133	172	0	195.20	42	90.41	CHANGED	PtlVIEHLEEssSEWL...LLEYpplAcphGs+hllTuupPE...............LRasss+luGVss-hccthsLcRu+VILLDLpAsc-LcPEDAocsoYIVVGGILGDHPPRGRTKcLpTuhhsultsR+LGscQhSlDGAl+TApLIAEG.hRLEEIEFEDsPEl+l-c....sS.sElsL+YAlPKlsGKlLLopGLL-LlKK-luYp-EDLu	.....................................................hallEHh-........thu......t......Ws...hLEYtpI..tc...-...s...G...s...c.....l..l..h.os.....sp..................................hh....h..s..h..tph..t..ul..tp......h...p.....p...h..s...h......c..+.u+..VCLLDPtApp-L............s.............P-Du....s.p.........F-hFlFGGIL....G..................Dc.PPR.DRTuELRpp.....Gh.uRRLGshQMTTDTAVRVT+lllcc..phs......l-cI.alDaPEl+hsc.....................pE.uTEM..PFRYV....hs.pp........G.......cPIhPcGMl-LIKcDssps.-...h......................................................................................	0	38	70	108
+5042	PF04359	DUF493		Protein of unknown function (DUF493)	Kerrison ND, Bateman A	anon	COG2921	Domain	This domain is likely to act in a regulatory capacity like Pfam:PF01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).	21.90	21.90	22.10	27.70	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.83	0.72	-3.61	166	1622	2012-10-02 00:29:19	2003-04-07 12:59:11	9	2	1588	3	338	823	238	83.00	41	87.90	CHANGED	hcshl.-FPsp.ashKllGt....s................sss..hhpt..lhpllpphh.s...sstslph+.sSspGpYhSlol.slpspup-plcslYppLs.shttV+hlL	...............h.ppLl.EFPss.FsaKVhGp..A.....................ts-..ls-p..VlEVlp+Hs..P...s-assps+.sSS+GsYpSVol.olpAos.hEQl-slYc-Lu.p.hchV+hVL....................	0	86	200	280
+5043	PF04205	FMN_bind		FMN-binding domain	Yeats C	anon	Yeats C	Domain	This conserved region includes the FMN-binding site of the NqrC protein [1] as well as the NosR and NirI regulatory proteins.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.82	0.72	-3.82	182	4808	2009-09-11 22:55:10	2003-04-07 12:59:11	9	81	2361	8	1029	3722	716	88.10	25	29.05	CHANGED	Ghsu......sl.plhl.......sh.....ssp.spIpsl...plhp........p......................p...........E.......Tsuhu....t.h......................pphh......pphhspp....................................................s.tp.lDuloGATloSpultpulppulpth	..............................................................................................................................Ghtu..sl.plhVsl....stp..up....lt..ul....plhp.............p...........................................................p..........E.................TsGlu....spht...........................h.spah..........pphhupp..........................................................................................tts..ss..l..DsloGATlTopulhpulppsh.................................	0	408	712	888
+5044	PF04432	FrhB_FdhB_C		Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	Kerrison ND	anon	DOMO:DM04087;	Domain	Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2].  The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).	21.30	21.30	21.40	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.36	0.71	-4.83	123	800	2009-09-10 23:45:23	2003-04-07 12:59:11	8	53	463	0	371	792	228	167.20	20	41.60	CHANGED	ptshc+lullGtPCplpAl+chpp........t................hhhhlGlhCspshshpsh..phltchhuls.ps.V.t+..................h-hpp....Gc.....ahlph........t.cus.......hhplslcch............t.hhpss.........CphCtDhssph.....ADlosGs...........hGs..........t.Ghoh.....lhlRocpGpcllctsh.ptshl-spshsst..........htKl	.......................................t...hc+lhhlGpPCplpul+ph.pp...t...h...................hhhlGlhCtss.hshpth.pchlpt..h.s.hp.....ps...lhc...................hchcp...............up........hhlph..................p...ssp..............hhphs.hpch.................................t.hhpsu......C.h.t.C.ts.h..ssph.....ADlolGs..................hus..............tGhoh.lllpop+Gpplhptht.pt..hlpht..............thttt.................................................................................................	0	116	255	326
+5045	PF04609	MCR_C		Methyl-coenzyme M reductase operon protein C	Kerrison ND, Finn RD, Mian N	anon	DOMO:DM04514;	Family	Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240) [1]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D [2]. The function of proteins C and D (this family) is unknown. This family nowalso includes family MtrC_related,	25.00	25.00	29.70	29.00	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.69	0.70	-5.59	18	122	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	65	0	81	118	17	201.70	34	82.52	CHANGED	M........hhapGGVa+csplh-hlEDl....GGallQ+p.ht.-lhh.hhlP.p-hc.lct.sc.hhGplscuPLsGoElAVVu.SLup+HLPHssCDIuEYLR+sGupoNMlGLARGsG..........+plutlsscEpclIpEHDLAVathGNFcsCIhphpttLh+tl-.l.P.lVVsGuP.-h.h..........YluslGRh.tRh+p.p-lttLcphs--lu+llscpRtslscDP..hoPshVh-hlpppl.sl.t.htPhPls.QhsGhRlKlPYDchs-tIcclc	........................................................................................................................+GplsEs..tts-lslVu.S.uR+Hls+ssC-IophLRctGhp..s..sh..lsLstGsG..............tshhslptcEhc.IpcHclAVhphGNhcspIl.Ktphlhc.lc.lP.llVstuP.-h.................................................t...............................................................................t...................................................	0	17	51	68
+5046	PF04607	RelA_SpoT		Region found in RelA / SpoT proteins	Kerrison ND	anon	DOMO:DM04456;	Family	This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologues in plants and in other eubacteria. RelA is a guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase (EC:2.7.6.5) while SpoT is thought to be a bifunctional enzyme catalysing both ppGpp  synthesis and degradation (ppGpp 3'-pyrophosphohydrolase, (EC:3.1.7.2)) [1]. This region is often found in association with HD (Pfam:PF01966), a  metal-dependent phosphohydrolase, TGS (Pfam:PF02824) which is a possible  nucleotide-binding region, and the ACT regulatory domain (Pfam:PF01842).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.55	0.71	-4.08	102	8755	2012-10-02 22:47:23	2003-04-07 12:59:11	12	55	4348	6	1707	5709	2333	115.20	41	20.29	CHANGED	GRhKphaSIhcKhpc..+s.............h...thcclhDlhulRlls..pp.........hp-CYpslsll+....shac.hss.....chKDY.............Iu.pPKtNGYpSlHssl................hG.pshhlElQIRThtMcthAE.GluuHhpYKpsts	.................................................................................................................GRsKclaSIacKM..pc...+p..................h...th.cclhDlhul...R...lls......pp................................lpDC.Yt.sL..u.h.lH.................sh..a..c...s.hss.........................chKDY.................................Iu...tPKs....N..G.YpS..l..HTsl..............................................hGsps..h..slElQI.RThpMcphAEh.GlAAHWtYKps.t.....................................	0	537	1087	1434
+5047	PF04226	Transgly_assoc		Transglycosylase associated protein	Kerrison ND, Finn RD	anon	COG2261	Family	Bacterial protein, predicted to be an integral membrane protein. Some family members have been annotated as transglycosylase associated proteins, but no experimental evidence is provided.  This family was annotated based on the information in Swiss:P76011.	25.20	25.20	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.45	0.72	-3.89	159	4300	2009-09-13 11:40:02	2003-04-07 12:59:11	8	3	2610	0	729	1905	66	48.10	36	57.58	CHANGED	IllGllGAhlGshl..hshhGh....hts.htluuh..lsullGAllLLhlhp.hlpp	......lllGllGAhlGuhL..hs.h.aG.............sluuh.....lsullGAllllhlhphlh..........	0	177	395	574
+5048	PF04264	YceI		YceI-like domain	Kerrison ND, Finn RD, Bateman A	anon	COG2353	Domain	E. coli YceI is a base-induced periplasmic protein [1]. The recent structure of a member of this family shows that it binds to polyisoprenoid [2]. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	20.50	20.50	21.00	21.00	20.30	18.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.38	0.71	-4.28	135	3875	2009-01-15 18:05:59	2003-04-07 12:59:11	8	16	2238	16	1127	2995	1071	164.90	25	82.66	CHANGED	sa....pl..............Ds..spoplsFpspc.....h.shsph.......G.pFs.p..hs....G....pl......sshsssth..shslchs..Sl..ss.....t....sthc..pc.lpst......paFcsppaPphsFpus.php.........h................ttt..hphp..GsLTl+GhT+s.lshss...plp.t.....................................................................ts.ps...............hshsup.spls.RscFGlshsthh.................luccV.plplplphp	................................................................................aplDs..sHoplsFphpH............h.shohh......GpFp.p....hs........G..slp.............s.ps..ssspl.........sloIsss...Slsoss......................spRD....pH.L+us.............DFhs.s..s..+aP..p.hoFpoo..plp......................t................pt..spls.....GsLTl+..GlT+s..l.slcs......phh.s................................................................................tu.ps............t.hsGhpus...sp...lp.RpDFGlshshsh.................luccV.plplplph.h...................................................................	0	378	777	993
+5049	PF04431	Pec_lyase_N	pec_lyase_N; 	Pectate lyase, N terminus	Kerrison ND	anon	DOMO:DM04067;	Family	This region is found N terminal to the pectate lyase domain (Pfam:PF00544) in some plant pectate lyase enzymes.	20.70	20.70	20.70	22.00	18.50	20.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.76	0.72	-3.88	15	105	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	30	0	39	93	0	50.40	37	14.34	CHANGED	sIu.EaDEYWpcRu--A+ptshpAYcPcP.sVTs+FNpcVtcuhp..........................ssNsTRRsL	......ls...-chWtp+tc.A+ptshtAYhsDPhslTscFNtcVhcuhp........................................................sRRt......................	0	4	22	30
+5050	PF05223	MecA_N		NTF2-like N-terminal transpeptidase domain	Bateman A	anon	Bateman A	Domain	The structure of this domain from MecA is known [1] Swiss:Q53707 and is found to be similar to that found in NTF2 Pfam:PF02136. This domain seems unlikely to have an enzymatic function, and its role remains unknown.	21.80	21.80	21.80	21.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.52	0.71	-4.03	17	954	2012-10-03 02:27:23	2003-04-07 12:59:11	6	6	730	10	155	737	7	115.00	23	18.53	CHANGED	sssppphppFlsAhsct-hsphhshsspss.........cht-thpslasulpscslcl.........tshpspcsscsphslsachphpsshuch...hshshphphscp-sp.Wp.lcWpsuhlaPphpcsp	.............................................t.pscpshppalsulsc..pcasphhp..ssp.u....p...t.sp.-hs-+hpplYsul..t.sc.slpl....................pphph.p..cs.s.c..sp.tplsaphphcT.shGpl.......................hshsh.phsh......s+....cc....s.....p...W+..lcWssuhIaPshpcsp.....................................	0	55	117	141
+5051	PF05224	NDT80_PhoG		NDT80 / PhoG like DNA-binding  family	Wood V, Bateman A, Glass NL, Moxon SJ	anon	Wood V	Family	This family includes the DNA-binding region of NDT80 [1] as well as PhoG and its homologues. The family contains Swiss:Q05534 or VIB-1. VIB-1 is thought to be a regulator of conidiation in Neurospora crassa and shares a region of similarity to PHOG, a possible phosphate nonrepressible acid phosphatase in Aspergillus nidulans. It has been found that vib-1 is not the structural gene for nonrepressible acid phosphatase, but rather may regulate nonrepressible acid phosphatase activity [2].	19.40	19.40	19.70	19.90	16.80	19.30	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.42	0.71	-4.29	16	421	2012-10-03 00:25:27	2003-04-07 12:59:11	7	11	202	16	306	408	0	168.80	30	24.03	CHANGED	palsY+RNaFplssshsh.t...sphhptshh..........................tsspphplphFtlclpAhcs.s.....spsIpLlQ.........tospccKs.thsPshsslhst..P...h.h.tsp.hs..t...................................splsphspacRLQFppuTssNt+ppt.....QpaFpLpVpLhs...............................sptsssphlhltphposslIVRGRS....Pusapsp	...........................................................asC.++NaFQlosph..s..h.....sphlp.......................................................sstshhslptFtlplpuhcstt........spslplhQ...............................o.pccp.t...hpPshh.sl....s..................................................................................................................................phsp.hohpRLpFp...puTANN.tR++u...........QpaFhLhVpLhA.....................................t.t.sp.s..phhhlutthSt.lIVRups....Pupaps.p...................................................	1	70	146	243
+5052	PF05225	HTH_psq		helix-turn-helix, Psq domain	Lehmann M, Bateman A	anon	Lehmann M	Domain	This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster [1]. In pipsqueak this domain binds to GAGA sequence [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-8.10	0.72	-4.41	27	1317	2012-10-04 14:01:12	2003-04-07 12:59:11	11	67	254	1	1002	1636	41	43.90	28	10.93	CHANGED	sp-pltpAlpslp.....sGt.hSlp+AuphaGlPpSTL..cthctthshpp	................ptplttAl.pslp...........sGp.hS.l.p..cAAphYslPpoTLh.cthpth.....t..............	0	324	585	881
+5053	PF05226	CHASE2		CHASE2 domain	Ulrich L, Zhulin I	anon	Ulrich L, Zhulin I	Domain	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE2 domains are not known at this time [1].	22.00	22.00	22.00	22.70	21.20	21.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.31	0.70	-5.19	160	950	2009-01-15 18:05:59	2003-04-07 12:59:11	6	44	512	0	409	1005	1318	318.30	20	45.69	CHANGED	lslshhhlhhhhhhtts..............hp.....h....-hth.....aDhhhphp.....s...............sc..llIVsID-p.............Sl...........t......up....WP.WsRshhApLl.cpL.............tpt.tspsluhDl..lF.scP.s............................................sDptLupul..tps...ll...ls.h..............................................htttppts..sht.................................................................................................................................................stlttt..stshGhh.shhh..Ds.DG.....llR....+h.l...........hss.t.hhs....ululphh..............thhhsspshtht...t......................................................t...t..................hhlsa........tus....tt......sh.....plSh..t-l....L.....s..uphs.......................shl....cs.+lVLlGs.o....As.ult......DhhsTPh............t..................hsGVElcAshlsslLs....................sp.hlh.hsshs.hhhhlhhshhhulhh	...............................................................................................................................hhh....hhhhh.h.hhhhh.h.......................hpt....h.....-hhh.....aDhhhphp.......................s..s..s.....sp.lllVsID-p...........................ol.................p........phGp..............WP.asR....s....hhApllppL.............tpt...tsp..sluhDl..hh..sps..p........................................................................................sDptLspsl...p..p..s..........ls...lshh......................ht.tt..ttt....h........................................................................................................................................................s.ltt......ssthGhh..sh.h......Ds..DG.......hlR.....ph.l..........................h.t..ss..p..hhs...........ululthh.....hhhhttp.s.hhh.t.t.t.......................................................................................hs...............s....th..p.......................hhlsa..........tus..............tt................sh.........plSh..t-l...L...........p.....splss................................................shl...cs+lVll...Gs..o......As..uht.........D.hhsTPh.........ts............................hsGVplpAphlsslls.........................tp...hl..h.....h...s..t.h..h..t...h..h.hh.h..h.hshhhhh..h..................................................................	0	126	275	353
+5054	PF05227	CHASE3		CHASE3 domain	Ulrich L, Zhulin I	anon	Ulrich L, Zhulin I	Domain	CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE3 domains are not known at this time [1].	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.54	0.71	-4.49	180	1210	2012-10-02 01:04:29	2003-04-07 12:59:11	8	127	733	1	487	1312	72	135.90	19	20.96	CHANGED	ssphlp+ohpllsph...pplhsthh-tEoG.RGYLLTucppa.LpPYpputsplpptlscLp..phs..s......-sP...tQppc....lpplpthhppth.shhcph...lshpcp.....t..shp...sshphltsspG+phhD.....plRphhs..ph.......tspE........ppllppRptp	..........................................t....lp+shplhsphpplht....tlhshEouhRGallo.s..c.p.s.....a...L.psYppu.t..t.p...hppplspLp..pL..s..t......csP........pQ.ppc....l.p.plpthhp...phh..p.hpth...lshtps..........t.t.p.....sshph..l.p.....s.....s.t.u+.thh-........plRphlsph.......psp.E.......pphhttRt..t...............................................................	0	132	288	404
+5055	PF05228	CHASE4		CHASE4 domain	Ulrich L, Zhulin I	anon	Ulrich L, Zhulin I	Domain	CHASE4. This is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in prokaryotes. Specifically, CHASE4 domains are found in histidine kinases in Archaea and in predicted diguanylate cyclases/phosphodiesterases in Bacteria. Environmental factors that are recognized by CHASE4 domains are not known at this time [1].	20.80	20.80	20.80	21.30	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.50	0.71	-4.65	95	529	2009-01-15 18:05:59	2003-04-07 12:59:11	8	79	398	0	207	499	16	160.10	17	23.09	CHANGED	ppslppphpplpphspDaAsWD-sYpalps..pst.t....alpsNls.sphh..pshpl-hhhllstsGphl.a..tpshshpsst..h.hst....................sltphlsphp.h....................ttttpsshsGllhhsssPhlluupsIhssssps.....sspGsLlhsRhlcsshlspl.pphshhslplth..s	.................t..hlp.phpphtphhtDaAhWD-shp..alts......tst..s.............ahpsNls..sphh..pshth-hlh.lh-spuphl.a..t.pst.sh.p.pstt...p.lst....................shpp.hlpphpth...............................sptppshsshhh...hs.st......s.hl.lusss.lpssssps......sstuh.Ll.hs+hlss..phlppl.pphshhslph....st...............................	0	64	129	167
+5056	PF05229	SCPU		Spore Coat Protein U domain	Yeats C	anon	Yeats C	Domain	This domain is found in a bacterial family of spore coat proteins [1], as well as a family of secreted pili proteins involved in motility and biofilm formation ([2]). This family is distantly related to fimbrial proteins.	22.40	22.40	22.40	22.50	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.07	0.71	-4.09	127	1343	2012-10-02 17:35:21	2003-04-07 12:59:11	10	3	332	0	336	1103	36	142.70	23	81.23	CHANGED	sssshsls..sslsssC...slsus.............slsFG..............ssssssssssss.usl...slsC....o......sssshslslssGtssssss............Rphts..uss......hlsYpLYpDuupoph..Wusssssshsss.................sussp....sls...lYGcl.............ssssss.uG....sYsDTlslT	..........................h...shsss...hslhssC....slsus.......................slsFG..............ss.s...s..s.ss.s..s.ss.s...usl....slp.C..........o.........sssshslslssGtssssss............Rphts.....suss......hls.YpL.Yp....-u.up..o.p.h........as.ssssts.sssst..................sussp............sls...lY.upls.....spsss...s..sG........oYsDTlsl....................................................	1	48	107	209
+5057	PF05230	MASE2		MASE2 domain	Galperin M	anon	Galperin M	Domain	Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins.	25.00	25.00	25.00	26.60	23.70	24.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.10	0.72	-4.01	21	590	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	566	0	64	308	10	89.60	59	24.31	CHANGED	+RhYhsRhlGhslshhsluuslhstshsthlWlLLlhtuhlWPHlAaphApR..uppPhcsEptNLhlDuhhGGhWluhMtFssLPolslLsM	.......RRlRLPRAVGLuGMF.LPIAosL..VopPssG..WWWLlLVGW..A.FVWPHLAWQlAuR...AlDPLp..pEIY.NLKsDAlLuGMWlulMGVNsLPSsAhLMh..........	0	9	19	45
+5058	PF05231	MASE1		MASE1	Galperin M	anon	Galperin M	Domain	Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This entry also includes members of the 8 transmembrane UhpB type (8TMR-UT) domain family [2].	29.50	29.50	29.50	29.60	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.95	0.70	-5.40	33	2684	2009-01-15 18:05:59	2003-04-07 12:59:11	9	142	1051	0	372	1651	78	274.00	22	40.20	CHANGED	hhlhhhhhhhlshhhsht.shshssssthslW.hPsGltluhhlhhshpthPsll......lushlhp........hhtthshhhshshshsssltshhushllchhhttttthpph.........................hhhh.sshhsshhsAssshshhhhhshhshs.hstshhhahlushsGsLllsPhshlhhphhhpphth........phh.p..ht.h.hh.hhhhhhhlhhhhshhh.hhh.s.........t...............hlhhssllasAhRaGhpGusl.hhhlhusllhhhththst.hsh..t......h.lp........hal..uhtshssl...hlushlpcpc	......................................h.hl.hhhlhhlh.h.hh..h..h....p.ht.h.h...s..s.........hs..l..a..hPhulh.l.u.hhh...h....h....s....h.t..h.hPslh..............huhhltp.............h..hht....h....s.....h...h.t..s....h......s......hh.....h.h...th...l.....s.l..ls.s....sll..Rhh.h..p..p.s.hshh.......................h.hh.h....hhh..hhhsshshhh.....h..h...h..p......h..s.h...s........h..s.ht..h...h.h.shlup..hs.GsLhh.sP.ls..h.h...h...h...c...h..l.h..p.....p.hh........................................h.h.p..........h.p..p..thh.hhlhhhsl.s.hh...h......h...h...h....s...p...........phhh.................hlhl.....lhah..A...h+hGh..tts..hl.............h.ls.slhh.hhshh..h..st...s.h....................................h..h.................hL...hh.ph...hs...sh....hushhpc..................................................	0	81	199	290
+5059	PF05232	BTP		Bacterial Transmembrane Pair family	Yeats C	anon	Yeats C	Family	This family represents a conserved pair of transmembrane helices. It appears to be found as two tandem repeats in a family of hypothetical proteins.	25.60	25.60	33.50	26.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.30	0.72	-4.23	181	1557	2009-09-10 14:54:21	2003-04-07 12:59:11	7	2	633	0	358	1134	42	67.90	31	89.83	CHANGED	+ohtpRlhHAlhFEhshlhlslPlhAahhshulhpshllsluhshhhhlasalaNhhaD+lhs..h.tsp	.......+ohtpRlhHAlsFEshhlhlssPlhAahhshol........hpsh..sLslshslhhhsashlaNhhaD+lhs.t...hhh....	0	55	137	243
+5060	PF05233	PHB_acc		PHB accumulation regulatory domain	Yeats C	anon	Yeats C	Domain	The proteins this domain is found in are typically  involved in regulating polymer accumulation in bacteria, particularly poly-beta-hydroxybutyrate (PHB) [1]. The  N-terminal region is likely to be the DNA-binding domain (Pfam:PF07879) while this domain probably binds PHB (personal obs:C Yeats).	21.40	21.40	21.60	26.40	19.70	20.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.99	0.72	-4.22	72	555	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	403	0	227	497	146	40.90	38	29.37	CHANGED	hssshLpQlIphYGsshQuhhssYLEpShphFtctQpphpc	....hssshLsQlIphYGssMQGhMssYLEpShphFhchQpphpp.........	0	48	136	179
+5061	PF05234	UAF_Rrn10	UAF_rrn5; 	UAF complex subunit Rrn10	Wood V, Bateman A	anon	Wood V	Family	The protein Rrn10 has been identified as a component of the Upstream Activating Factor (UAF), an RNA polymerase I (pol I) specific transcription stimulatory factor [1]	20.80	20.80	20.90	21.10	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.44	0.71	-4.08	2	57	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	56	0	37	47	0	105.20	36	57.86	CHANGED	Ms.N..sh.sh.Nllpt.GphshpAc-llt...D.uVPIP....cEl......D...........PDl.l+slp.aATphhLsph.+.hpshDEouLlsLGhLlpcWhcshlTsh.pE.tcp	..............................................................................................l.lPh..hp.h...............sphlP..D.D.L+slHYY.Ao.ph....s...L...s....+.....h.........chh..p...uhDETuLIsLGlLlEcWsc-hlst........t.tt................	0	4	14	29
+5062	PF05235	CHAD		CHAD domain	Aravind L	anon	Aravind L	Domain	The CHAD domain is an alpha-helical domain functionally associated with the Pfam:PF01928 domains. It has conserved histidines that may chelate metals [1].	22.70	22.70	23.10	23.50	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-12.01	0.70	-4.78	186	1090	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	934	2	406	1065	129	229.00	20	53.54	CHANGED	pt.hhtpplp......phhtp..pssl.tps.........-s..EslHphRVulRRLRohlpha.ps.hh.....pthtthp.pcl+tluptLGssRDh-Vhh........tpht..............sthttt....................................................................shttlhptlppp+..pps....tpphtttLputchpphltpl....pp.hl.tt........................................................................................t...htphssptlp....cthc+ltcthpp.t................................................p..sp.p.h.HclRhtsK+LRYshEhht....sh.............sttt..hp....phhcpl+plQ-hLGphpDhsl.ttph.lpph	..........................................................h..hhtpthtphhtt...pttl..pps.........ss....-ulHphRVuhRRLRohLpha...ps.hh......s...tt...tss....tlppcL+hLuphL.......G.hRDh-Vhh......ppht...............htth...............................................................................................shpt.lhpthppp.p.......pt..s....tp.p....h..h...p..t..L...p....o..tca..tp.Llh.sl....pt....hl..s.t..................................................................................................................httshpphsspplc.....+thccl.h.ct.httht...............................................t..............p..sp.t.hHplRhtsK+lRYshEhht.......h..........................................tt......hp...........phhpthctlQshLGphpDhssttthl...h.........................................................................	0	122	261	346
+5063	PF05236	TAF4		Transcription initiation factor TFIID component TAF4 family	Wood V	anon	Wood V	Family	This region of similarity is found in Transcription initiation factor TFIID component TAF4 [1].	24.10	24.10	24.60	24.10	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.79	0.70	-5.11	26	410	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	239	2	271	367	0	237.20	28	39.18	CHANGED	lNDVhusAGVsLpEEEthLhus.............ophhtshscpsccps......FLp.ttLtphlpcl.................................u..pcps...........hphss-lhpLlSpAscphLpsllpKhhllScHRpcuhK................................t.phthpS-VptpL+tls.hpKp-c-R+tp....cctthhL............Ec.pp....tcstt.s+t-s-chppRsANsTAthtlG.....s+KKaphhsusst..............Spss.....sht.tsstp.ssh......ptp.......hRtt.s..................Ish+DlLhsLEp-R.hs.p......phlhKuYt	....................................................................................lsDlhshuGVslpEEpt.lhts.................o..phhtp..hpp.p...pc.ps.....................F...L..s..Lpp+l.h.cl..............................................s...pcps..............lpphps-.llshlS......tAsppRLpsllcchhhluppRhps.h+.....................................................................sstp.ht..ssD.l+t.pL+hhpp...h-ph-cp....+..+pp......p.-p-.......hh...h+t....u.c..sp.........................stt.....-D..s-p.ph.Kp+sK.c....h.....ppt-.......tp.h.p.p+.s.ANhTAhtAlG............s+K..K...hph.sss.s...........................................stst...........s....s.tst.t..t.............................hc.t.p.....................................................lsl+DllhshEp-tth..p.......hh.....h.................................................................................................................	0	79	127	203
+5064	PF05237	MoeZ_MoeB		MoeZ/MoeB domain	Cortese M, Bateman A	anon	Cortese M	Domain	This putative domain is found in the MoeZ protein and the MoeB protein. The domain has two CXXC motifs that are only partly conserved.	26.90	26.90	26.90	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.74	0.72	-4.39	41	4751	2009-01-15 18:05:59	2003-04-07 12:59:11	8	17	3320	13	1252	3468	1698	83.20	33	27.48	CHANGED	spsPCYRClaPp....st.sssCspu..GVlGslsGhlGslQAhEAlKllsGh..ucslsu...pLLhaDuhsh.cacpl+lp.+cssCssCGsps	..........................t.tsPCYRCLa.sp............stss.h.o.C.s.pu...G..V........luPllGl.lGolQAhEAl.KlL.s....Gh.........ups.h.sG...................+Llha....D.....uhs....h..p.......a+p.l.p.lp...+s.s..sC.s..sCGt..t................................	0	397	765	1050
+5065	PF05238	CENP-N	CHL4;	Kinetochore protein CHL4 like	Wood V	anon	Wood V	Family	CHL4 is a protein involved in chromosome segregation [1]. It is a component of the central kinetochore which mediates the attachment of the centromere to the mitotic spindle [2]. CENP-N is one of the components that assembles onto the CENP-A-nucleosome-associated (NAC) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [4].	25.00	25.00	32.30	25.50	20.10	24.20	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.07	0.70	-5.42	29	193	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	158	0	124	186	0	374.10	25	94.03	CHANGED	s.ss.slh+.hLs+Ls+ssLlsLshpWhppps.................................t.h..tt.lpplpp......hppLpptpsp........KRpll-+IlptsWppGlsLhQlA.lDhth.lh-+Psuh.pWsshplp..................tcsspslsphcsspFlspLppplpslhcsahhl...sRcssLPllhlRIhlhs.s..p.......................ts.psthsop+shYlsasssoPalapSh..sss.h.t...........................+llhpuls+ALotsppphtl...pssphss+s.LpuLhslpG.su....Rps..suhGuao.aA-ssh.........................-.sPL.ssh.pp....tp.................psppp.sppsspppp...........................+pcphspt+Fusospsh............l-phph+l.s..sup.s.t................................................hppspppsplplphsGsclhuGl+cLs......ctGllDspchPuWhT....G..Ecusosuhl+cG	.....................................................s.ss.hlh+.tlh+lshspLhslhhtW...pp.......................................................ppLpphphp...........Kcpllp+llphs.ccu..lolhQlA.lDhha.h.p.+spph.h.....Wsshph.................................tpss.t.sl...sthc.ppFhpshppplp..hh+shhhh...hRctp..shlhlRIhh..............................tsthst.sph+shYlsa..spoPa.lahSh...sp....................................chhh.hlspALohsppphpl....thsLss+s.LcsLhslhh..t....tpp..tutusao.at-ts.h..................................c..sL.p......t..........................................ptt.h..ppp..tpc..........................................+hpphsptpFGssspst...............................................lchhp.h+lps.h.psp.sts..........................................................................st.ppp..phhlpFsGsclhtul+pLs.......................tGlhDs..hsshhTs..ccuhs.hhlcpt........................	0	22	49	90
+5066	PF05239	PRC		PRC-barrel domain	Aravind L	anon	Aravind L	Domain	The PRC-barrel is an all beta barrel domain found in photosystem reaction centre subunit H of the purple bacteria and RNA metabolism proteins of the RimM group. PRC-barrels are approximately 80 residues long, and found widely represented in bacteria, archaea and plants.  This domain is also present at the carboxyl terminus of the pan-bacterial protein RimM, which is involved in ribosomal maturation and processing of 16S rRNA. A family of small proteins conserved in all known euryarchaea are composed entirely of a single stand-alone copy of the domain [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.33	0.72	-4.11	114	6817	2012-10-02 14:14:57	2003-04-07 12:59:11	11	26	3995	121	1960	4958	1373	76.30	21	44.59	CHANGED	.p.hhhsclhGhpVhsps.G...cplGpl..p-lhl-ht.ssclhhlhlshst...............cphhlPhp......thchtpctlhlpshptth	.........................................hhhp-lhGhp..V.hsts..G...................pp...l..G..p.l...p-l.......l....css....u.....s.....c...lhs.......l..t.h.s.t.t.........................................cchl.lPah.............h.pl.cls.s.ctl.hlp......h...................................................	0	622	1275	1636
+5067	PF05240	APOBEC_C		APOBEC-like C-terminal domain	Yeats C	anon	Pfam-B01590	Domain	This domain is found at the C-termini of the Apolipoprotein B mRNA editing enzyme.	23.50	23.50	23.90	24.30	22.80	23.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.01	0.72	-4.56	45	86	2012-10-02 00:10:39	2003-04-07 12:59:11	9	5	33	4	13	662	0	54.00	44	23.25	CHANGED	cspapcGL+pLppuG....splplMsap-FpaCWcsFVcpp.............tps.FpPWcpLpc...p.phLp	......s.apcuLphLppu.G....AplsIMsYs...EFpaCWcsFV-pp.............spP..Fp.PWcsLc-...pSptL.p.................	0	7	8	9
+5068	PF05241	EBP		Emopamil binding protein 	Moxon SJ	anon	Pfam-B_7320 (release 7.7)	Family	Emopamil binding protein (EBP) is as a gene that encodes a non-glycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains, including the sterol acceptor site and the catalytic centre, which show Delta8-Delta7 sterol isomerase activity. Human sterol isomerase, a homologue of mouse EBP, is suggested not only to play a role in cholesterol biosynthesis, but also to affect lipoprotein internalisation. In humans, mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities [1].	31.00	31.00	31.20	31.30	30.80	30.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.48	0.71	-5.29	46	404	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	197	0	278	388	0	182.60	27	79.73	CHANGED	llshhhsssssllssshhls......thh..phstsc+hshhWashsu.hlHhhhEGhFlhpptphss......................................spshh..........................upLWKEYupuDoRYhss.....DshllslEslTsllhGPLuhhlshtlhpp...................cshRahLQlllshupLYGshlYassphhcuh........shshsp.sp.hYaWhYalhhNslWlllPuhllhpohppls..tAh.sth.....pps	.....................................................................h.....h.h.hhlh.hshhhs........hh.......ths.t..hc+hhhhWashs.................u.hl....HhhhE.G.Flh.phh.h.hs............................................................spshh...........................upLW...+...EY.u.pu...DuRYhss........DshllshEhl.Tsh..lhGPluhhhsahlhpp..................................c.shp.a.hl.plh.lu.l....u..plY.G.....shhYas..sphhsu..................s.shsp.s.p.hY.hW........hYhl.h..hNs.lWlllPhhllhpuhtplstuht.....t............................................	0	68	140	213
+5069	PF05242	GLYCAM-1		Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)	Moxon SJ	anon	Pfam-B_7429 (release 7.7)	Family	This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a  saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph  nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has  been shown to be a critical structural requirement to be recognised by  L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus  and rat cochlea [1].	25.00	25.00	36.40	36.40	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.74	0.71	-4.24	4	14	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	11	0	4	22	0	122.40	48	88.94	CHANGED	hLstsKDElahcoQPTDA..uAQhh....hSpcpsSScDLSKEPSI.RE-LlSKDsVVIcSs+.PQNQpsp........cuLRsuooQpEETTc.ssuuAoToEGKLscLoppl.KpLtpslcthlshlcslhssASclVKP	........LscscDEhHhcoQPTDA..uAQhh....hSc-plSscDLSKEsSI.+EELlSK-sVVIcSs+.spsQpsp........cslRsus.Q.EETTc.ssp....uAoToEGKLscLuppl.+pLtpshcthhshlcslhssAscls+P...	0	0	0	0
+5071	PF05244	Brucella_OMP2		Brucella outer membrane protein 2	Moxon SJ	anon	Pfam-B_7448 (release 7.7)	Family	This family consists of several outer membrane proteins (2a and 2b) from brucella bacteria. Brucellae are Gram-negative, facultative intracellular bacteria that can infect many species of animals and man [1].	19.20	19.20	19.40	21.90	18.30	19.10	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.70	0.70	-5.21	2	23	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	16	0	0	20	0	179.50	87	61.52	CHANGED	MRSLQlEGsLhtu..LpTTPDSPIAAPLTVVLVRRRCGRICALQP.RE.VGDVDVATNLsSPFFDDRVIGNNTSDRTPAASIhQAANNVRHVsVDhV.....lsssVhATLFESDHSREAVSAuEGVtDLAGAVGASRDHVIVDDIsEVTGEGMEFtFlDTNhpTTchDIpcLp.GAuA........YAtI.....p.............................sIslhstlsVlAhh	MRSLQlEGsLhtu..LpTTPDSPIAAPLsVVLlRRpsGRICALQPNRELVGDVDVATNLGSPFFDDRVIGNNTSDRTPAASILQAANNVRHVAVDVVVGRASVTTVVVATLFESDHSREAVSASEGVRDLAGAVGASRDHVIVDDIAEVTGEGMEFRFIDTNAQTTELDIRELHDGAAA.GFITIFTIYARIVRSIVEAQFGEGLEGAEFGFRTGGNAECETSALVPAIAVGTGVNVIAAL......	0	0	0	0
+5073	PF05246	DUF735		Protein of unknown function (DUF735)	Moxon SJ	anon	Pfam-B_7611 (release 7.7)	Family	This family consists of several uncharacterised Borrelia burgdorferi (Lyme disease spirochete) proteins of unknown function.	23.40	23.40	24.60	24.60	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.31	0.71	-4.57	2	138	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	28	0	10	101	0	180.50	68	99.27	CHANGED	hcIPphhcNTpIcKFIpsEh-YtptlLpELKpL.pNF.oINVhpsIpS+YIAlhh.plhshFahKpph.pslssslsulIFAl+pIGTDESFhllFKsFLpsslEVoosE..sG.I.IpLhGsIKoshph.Iu..sKptp+LKKIhh+.....aAu.KKALs.N.hPKsYcpSlYtFIKhlIPIGRllK........IpsTcspph.Thsp	.....MKIPNhhcNTEIcKFIhTEhEYAQtLLNELKpLNSNFlSINVhENIKSRYIAIWISQVLSIFYAKTQTLQSITSNINSVIFALRHIGTDESFRLIFKAFLNVDI-VT...TPE..AGVIDISLKGsIKTNFTTFISP..STKKGKR....LKKIllREKK.GYAASKKALVFNSLPKGYDHSIYAFIKtIIPIGRVLK........INspcGpNIITFNN.........................	0	6	6	6
+5074	PF05247	FlhD		Flagellar transcriptional activator (FlhD)	Moxon SJ	anon	Pfam-B_7623 (release 7.7)	Family	This family consists of several bacterial flagellar transcriptional activator (FlhD) proteins. FlhD combines with FlhC to form a regulatory complex in E. coli, this complex has been shown to be a global regulator  involved in many cellular processes as well as a flagellar transcriptional activator [1].	21.30	21.30	21.30	23.70	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.12	0.72	-4.03	29	772	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	693	6	122	317	10	100.70	60	90.55	CHANGED	Ms.ss-lLp-I+-lNLSYLhLAQphlppD+A.sAhFRLGISc-hADlLtpLo...AQllKLAsoN.LlC+FRFDDpt.llshL.Tpp.....s+scslsphHAuILhAupsscpl	...............MpTSELLKHIYDINLSYLLLAQRLIspDKA.SAMFRL.GIsEE.MAssLuuLT..LPQMVKLAETNQLVCHFRFDsHQ.TIopL.TQ-............SRVD....DLQQIHTGIhLSoRLLp..s......................	0	7	46	85
+5075	PF05248	Adeno_E3A		Adenovirus E3A	Moxon SJ	anon	Pfam-B_7497 (release 7.7)	Family	\N	25.20	25.20	25.40	37.00	21.60	24.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.78	0.71	-4.03	11	109	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	83	0	0	74	0	105.20	56	97.52	CHANGED	MssssA-hsRL+.....HhcHCRR.+CFAR-slphsYFplPc-H.pG........PuHGVRlslpsshcS+hl+hhstRPlLsEpcpGsoplolhCICs.pPuhHpsLhstLCutYN+s	.........pusuAELARLR.......HLDHCRRhRCFARE.utthIYFElPEEHPpG........PAHGVRITlEGsh-S+LlRhFoQ+PlLlE.R-pGsTTlTlYCICs.pPtLHEshCCpLCuEFNKs...............	0	0	0	0
+5077	PF05250	UPF0193		Uncharacterised protein family (UPF0193)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	23.30	23.30	23.30	25.90	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.56	0.70	-4.76	5	117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	86	0	77	119	0	176.20	35	81.17	CHANGED	hAupWPSsRVAKG..GlF..HosKApYTKETQDLIKVLMEESKLThLQR++Is-+LRsGEPLPlPcpP+hpQphs...phLs........Msst++NhKKRSLpsI.tSGAac.EhYh.PtcsK..sEKpKpKLQppMA.Gp+l.PDsGhRK+hPR++u-csh-hsEsDRhsELL-EINERsEWLsEMEALGQGKKYRslIpsQIAEKLRELccLDR++SpEs-huht.l	...............................................................................................................t.l..G..sha..ps....stYo.tTp-Ll+lhMcESKlo..hpp+pl.cph+pG.psLPh......p.....Ppsspp.........t..s...........................hh......t........h...+sh...p....hpss.sAYppp.a+..P.p.ss..+........hEKpKp+.LQs..hhA..G..............-.t...+.............................s.........h.tt....cp..t.....c..DhhpE..LlpEIpERtEFLs-MEuLGp.G+.pY.+shIhsEIup+l+chctl-pphp.p.p......h.............	0	29	37	56
+5078	PF05251	UPF0197		Uncharacterised protein family (UPF0197)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	23.20	23.20	23.20	23.90	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.62	0.72	-3.67	6	160	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	121	0	102	147	0	75.10	54	77.54	CHANGED	l-pMsRYlSPVNPAVaPHLAsVLLuIGhFFsAWFFVaEVT..........SoKasRslaKELLISLsASlFLGFGlLFLLLhVGIYV	................MpRYsSPVNPAlaPpL.slVLLuIGhFFTAWFFl...YEVT......................So..KhsRslhKELLlullASlFhGFGs....LFLLLhVGIYV..................	0	37	49	79
+5080	PF05253	zf-U11-48K	UPF0224; 	U11-48K-like CHHC zinc finger	Bateman A, Andreeva A	anon	Andreeva A	Domain	This zinc binding domain [1] has four conserved zinc chelating residues in a CHHC pattern. This domain is predicted to have an RNA-binding function [1].	21.10	21.10	21.60	21.30	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.14	0.72	-6.90	0.72	-4.20	84	695	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	184	2	441	662	1	26.70	35	12.17	CHANGED	clhsCPasssHpl.tpclptHltp.Cpc	.....hh.CPasssHpl.tsclppHltp.Cpp....	0	121	173	310
+5081	PF05254	UPF0203		Uncharacterised protein family (UPF0203)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	21.50	21.50	22.00	22.30	21.20	20.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.60	0.72	-4.12	19	246	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	207	0	182	247	0	68.30	36	54.14	CHANGED	Ms..ShutECs-hKccYDpCFNcWYuEKFL....KGctsp..stCschaccYppClppsLpc+sIp......ph.L-pu+cc	............Ms..Slu.pCs-lKccYDsCFNcWauEKFL...................K.G..pssp.......stCsplacpYppClpculcc+tIt......ph.httt+.................................	0	65	101	149
+5082	PF05255	UPF0220		Uncharacterised protein family (UPF0220)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	25.00	25.00	25.70	25.50	23.00	23.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.02	0.71	-5.00	24	399	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	275	0	246	338	0	149.70	34	93.88	CHANGED	Mst..p..haRh.....ch.tsspt+phulYlAGsLFuhGaWhhlDAulaSpps.p.st...l.......HlsFlDWlPhlhSTlGhllVNSI-KupLp...s-uhup.............usssAhtARlhLFlGFuLhAGGluGolhVhllKallpth.shsslhhGlANllsNshIhlSsllLWhup.shEDEYs	...............................p...h+......ph..stptpshushsAGsL........FhhGaWlhlDAulh.sp..p......................................plsas..ahsGlhuoluhlhlNuVp.puplpu.-uast.....................GshsthtARlhLF.lGFhLhhGuLhuShhlLhh....talsp......................ths...sla.GlAshh.pNshlhhu.sllhhhup...hE-.a...............................	0	76	123	193
+5083	PF05256	UPF0223		Uncharacterised protein family (UPF0223)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	25.00	25.00	31.60	31.50	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.91	0.72	-3.87	35	928	2009-09-10 20:58:59	2003-04-07 12:59:11	7	3	925	2	80	364	1	84.60	50	95.57	CHANGED	hsYpYPLDh-WSTEEllsVlsFastVEpAYE..pGlcp-cLLssY+pFKplVPuKuEEKpls+-FEcsSGYSsY+sV+pAKcssct.hlph	...hpYpYPlDh.s.WosEEhhtVlsFaspVEpAYE..suVpsccllsuY+pFKplVPSKuEEKpls+EFEpsS.GYShY+uVQtAKppsct.plp.l.............	0	18	40	63
+5084	PF05257	CHAP	AXE; 	CHAP domain	Bateman A	anon	Pfam-B_2845 (release 7.7)	Domain	This domain corresponds to an amidase function.  Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where is functions as a glutathionylspermidine amidase EC:3.5.1.78 [1]. This domain is found to be the catalytic domain of PlyCA [4].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.95	0.71	-4.47	47	5579	2012-10-10 12:56:15	2003-04-07 12:59:11	11	106	1721	22	443	2917	78	122.10	25	30.57	CHANGED	pthttpssshst.tsastsQCs.astphhtphss...........h.phhGNAts..........Wstss.thpua........ssstsPpsGslhsa..........tsssssYGHVAhVppV...tsssslpl.EpN..........h..tshshtshcph.st.......s.hsaIh	..........................................................tht........hsttphYstuQCT...ha..shphh..hus...............h.s.hh...G....s...Aps......................Wss.sA...ttpua......................psspsPp.s.Gu.lh.h.............tsssusYG..HVAhVppV...............s.s.s...s...l..p.luE.N..............a.....t.s...h...hhs.+sh.t........t.htaI..........................................................	0	112	217	369
+5085	PF05258	DUF721		Protein of unknown function (DUF721)	Moxon SJ	anon	Pfam-B_7527 (release 7.7)	Family	This family contains several actinomycete proteins of unknown function.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.51	0.72	-3.77	167	2098	2012-10-01 19:58:36	2003-04-07 12:59:11	7	3	2068	0	633	1679	1349	88.60	18	55.78	CHANGED	sls.pllpph.h..pp..ttht.pshthsplhp.tWppll...GsplAppspshpl.c...............su........s..LhltsssushtppL.phhptpllpclspth.s.....thlpclpl	...................................tthhpph.hpt....tthp.pshthtplhp.pWppll.............G.splu....spscshpl..c..............................su........s..LhltssssshuppL.ph.hpspllpplppth.s.........tslpplph.................	0	197	420	538
+5086	PF05259	Herpes_UL1		Herpesvirus glycoprotein L	Moxon SJ	anon	Pfam-B_7535 (release 7.7)	Family	This family consists of several herpesvirus glycoprotein L or UL1 proteins. Glycoprotein L is known to form a complex with glycoprotein H but the function of this complex is poorly understood [1].	19.60	19.60	20.10	20.90	17.50	16.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.40	0.72	-4.59	14	77	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	36	1	0	71	0	104.90	33	53.27	CHANGED	shshtshhssslssILphsChs....sshhhsh.sspshspsl.sGIhl+scCssPEslLWacpsppAYWVNPalsspGhh..EDltcsthssss.........+stlhpsLssth	.............................hhhtshhspplusILclsCls.s..cshsaph.sss.....shs.sl.sGIhl+hcCss.EslLW.cpstpAYWVNPalhltGhh..-Dlscsuhs.sss.........hctlhpuLssh.t.........	0	0	0	0
+5088	PF05261	Tra_M		TraM protein, DNA-binding	Moxon SJ	anon	Pfam-B_7584 (release 7.7)	Family	The TraM protein is an essential part of the DNA transfer machinery of the conjugative resistance plasmid R1 (IncFII). On the basis of mutational  analyses, it was shown that the essential transfer protein TraM has at least two functions. First, a functional TraM protein was found to be  required for normal levels of transfer gene expression. Second, experimental evidence was obtained that TraM stimulates efficient site-specific single-stranded DNA cleavage at the oriT, in vivo. Furthermore, a specific interaction of the cytoplasmic TraM protein with the membrane protein TraD was demonstrated, suggesting that the TraM  protein creates a physical link between the relaxosomal nucleoprotein  complex and the membrane-bound DNA transfer apparatus [1].	25.00	25.00	34.30	33.90	24.00	20.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.28	0.71	-4.08	8	222	2012-10-02 15:10:05	2003-04-07 12:59:11	6	1	171	17	11	121	0	120.70	70	98.53	CHANGED	MPKlQsYVSspVhEcINsIVEcR+tEGAc-pDVSFSSlSSMLLELGLRVYEhQhE+KESGFNQhEFNKlLLEsllKophhss+ILslpsLos+lsuss+F-apsllpsIcccVpEpM-hFFP-s-DE	.MA+VplYlSs-lh-KINtIlE+RRpEGA+-+DlSaSusuSMLLELGLRVYEA.....QMERKESAFNQsE.FNKlLLECVVKTQSoVAKILGIESLSPHVSGNPKF.EYANMVEDIREKVSuEMERFFPcND-E........................................................	0	0	0	6
+5089	PF05262	Borrelia_P83		Borrelia P83/100 protein	Moxon SJ	anon	Pfam-B_6712 (release 7.7)	Family	This family consists of several Borrelia P83/P100 antigen proteins.	25.00	25.00	25.20	25.20	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.78	0.70	-6.22	3	126	2009-09-13 12:24:55	2003-04-07 12:59:11	6	7	67	0	21	122	3	520.80	46	87.98	CHANGED	++ElDpV.NtTlEFlNYsGPHDsVDSA-sIRGIGEsLAuAL+uGsAGDp..uRYuVIHsVDPpsKcGhDADIFIIGupAcVDHIsNlRcIlAGYLpAAYGYccpDAcTIA+FlTIYNAVYRuDLDaFKp+YKpVVTKsLTKE+AGLARRYDQWPGKTQIVIPLocptaSGsl.SuVDTsSISDKKVVE+LREDs-KsV-hRRDMlDL..............................................KERESQEuAKRAQ.hKcEuDpKQc-ADKtppcADpAQcsADKQR+EscQKQQE.......AKNuP-PAcTousKEDK+V...........A......EppK+EhEKuQpEscKssEEApKAKDpt......A--LK+E..uKupEK.......hAEcKotEAQ+-Rc-VAu........................................DhQKhhsps+AcsTutu--....AI-SSsPsYGLKVVDsp+hLSELVLlDLKTEscLRoSulpTIRsRsLYpcsKsLVAIAsT.SGNAslpLVcIDsKoLEVlKESspcIAupSsLl+sup.hhsul..pDDssKWhlu+assK.L-..hhStsclLPaTsa	.......................................................................................................................................................................................................................................cKL+DFV..N.hDLEFVNYcGPYDSosTYEQIlGIGEFLA+s..Lh....su..sS..NSsh....hGKYalsRaID-pDKKu.SsDlFSIGucSpLDSILNLRRILTGYLhcuFcY-+uSAELIAKsITIYNAVYRGDLsYYKthYIpsuLKsLoKENAGLSRVYSQWAGKTQIFIPLK+sILSGpl-SDIDlDoLVT-KVVsuLLo.ENE.u.GVsF.AR..DlTDIQsEh+csDQcKIDhE.sshcp.c......................................................................sp.ppphps.pcp.pctos-ppcKE.IESQlDAKK+Q..KEEL.D.....cK..shc....LDKAQ.......QK..L.D...tuc.-sLDlQ.RcsV.+EKlQEsIschN+-KNLP.KPG.DV.SSPK.V....DKQLp.........tphQtp.p.........cssDEsQKREIEK..QIEIK..KsDEE.LlK.sKDt+.......AhDLpp-.....SKuSSKp................................p.hsEcKch.-......uK+phcsluc..............................................................................hsLQcscsQs+sps..T..shsp-........ul-SusP..VF...LEVI..D.Ph.T..NL.GsLQLIDLsTGscLKcSsppGIpR.....YGlY.ER-+D........LV...................VIKh-.SGc....AKLQ....lLs.KhENLKVlSESsF.EIs+sS.SLYVD.S+MILVsV..cDsussW+LAKFSscsL-cFlLSEscIhPFTSF.................................	0	11	14	16
+5090	PF05263	DUF722		Protein of unknown function (DUF722)	Moxon SJ	anon	Pfam-B_6789 (release 7.7)	Family	This family contains several bacteriophage proteins of unknown function.	29.80	29.80	29.90	31.40	29.70	29.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.73	0.71	-4.01	7	87	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	63	0	15	69	1	127.80	31	92.67	CHANGED	MADKLDRIIuDYlsG+LpA+IKuhE.Ralh+pKsD.NLGhRTA.sGsuc..uphLppEt.EsDcELh+L+cphphlshaacsLhtp.EKclIpL+apthtthoWYpVh.cLs......ls.ppA+phahpF+psIhph	..........................MAD+lDclluDYhsGhlpscIcth..c...chhh..+.ppsD..NlGhtsu.sssucsEscslhp...EsDccLt+Lcc.hphl-hhhpsLhs-....-KclI.pL+appt.tthTWhpVu.cLs......lscppA+phhhpF+p.l...h...........................	0	5	5	11
+5091	PF05264	CfAFP		Choristoneura fumiferana antifreeze protein (CfAFP)	Moxon SJ	anon	Pfam-B_6800 (release 7.7)	Family	This family consists of several antifreeze proteins from the insect Choristoneura fumiferana (Spruce budworm). Antifreeze proteins (AFPs) and  antifreeze glycoproteins (AFGPs) are present in many organisms that must survive sub-zero temperatures. These proteins bind to seed ice crystals and inhibit their growth through an adsorption-inhibition mechanism [1].	25.90	25.90	27.10	26.90	25.30	25.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.89	0.71	-4.40	4	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	4	17	0	49	3	59.70	45	103.26	CHANGED	MKhhMLIMALA.IsTVSSDGoCsNTNSQlotNSpCV+SThTNCYIDNSpl...............................YsTTCTGSpYDGVaITSSTTTGTpISGPGCoISoCTITtGVsAPSAAC+ISGCTLpAN	..............................lo.NS.C.pSThTNC.lspSpl...........................pSpl.toTCTsSpas.GlhIToSToTsoph....................................	0	0	0	0
+5092	PF05265	DUF723		Protein of unknown function (DUF723)	Moxon SJ, Finn RD	anon	Pfam-B_6852 (release 7.7)	Family	This family contains several uncharacterised proteins from Neisseria meningitidis. These proteins may have a role in DNA-binding.	20.90	20.90	21.10	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.12	0.72	-4.17	6	74	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	23	0	6	29	9	60.50	46	34.44	CHANGED	huhTFppAtochs-+FPc..lpLlcFsGltcPsoIsCPhHGsVshSsa.puhI+SKaGCPcCu	.....................huhoFppAtu+hpp+FPc...lsLl-FsGlhtPsolpCPhHGsVphusa.puhl+.SK.h.G..CPcCu.	1	6	6	6
+5093	PF05266	DUF724		Protein of unknown function (DUF724)	Moxon SJ	anon	Pfam-B_6894 (release 7.7)	Family	This family contains several uncharacterised proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.	25.10	25.10	25.20	25.10	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.22	0.71	-4.68	15	90	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	12	0	62	86	0	176.20	27	27.11	CHANGED	hhlP....FsK+tshWKshEohEVFKplPQuPHFsPLh.cscE-hREhsAlGhMloFhsLL-cVpsLplD-shSplpslspsFsELEKHGFNVpsPpSRIsK...lLoL+scpocph-EhKshEKchs-c...........p..-sthschEccIlELpRpt.hhpctKEst-.......pEIuphcopAsplcQplpss-h-FposhuAPW	..............................PFsKpt.hWp.hE.sh-VFchlPQpPHFpPL..ph..thREhhAlGhMhoFssLl-plppLpl-D.s.ts.hpshhc.slscLEc.pGFsVpslpsRLsc....LLsl+scpsphhcct+ph-cphtcc.......t....pph-pphtcl-pclh.....cLccpt..htphppttp.................t-lsphpspsptlppphtshchcFpshhst..............................	0	10	24	45
+5094	PF05267	DUF725		Protein of unknown function (DUF725)	Moxon SJ	anon	Pfam-B_6905 (release 7.7)	Family	This family contains several Drosophila proteins of unknown function.	20.80	20.80	21.10	22.90	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.77	0.71	-4.22	11	174	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	15	0	81	172	0	122.40	25	50.34	CHANGED	sssshospCFshYlPhlNpluspasssYssClssAssptpslssphppsppslppSuppsCssh.psC.......sohssshshFpCaAssusssspshYsISuNAopuAsplpcphpslcspc.pCsNpTp+s	.............shpCFshYhshhsplsspYstsYstChsstpssppplspphpppppplpssspphCssl.psC.......s..sh.sss.h.s.hFsCaussuspsspshaslusNAo..ptssplppphphlphpcttCsspupp..........	0	11	12	50
+5095	PF05268	GP38		Phage tail fibre adhesin Gp38	Moxon SJ	anon	Pfam-B_7415 (release 7.7)	Family	This family contains several Gp38 proteins from T-even-like phages. Gp38,  together with a second phage protein, gp57, catalyses the organisation of  gp37 but is absent from the phage particle. Gp37 is responsible for  receptor recognition [1].	25.00	25.00	31.70	29.40	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.92	0.70	-4.96	8	76	2009-09-11 08:17:54	2003-04-07 12:59:11	6	1	63	0	0	45	2	168.10	45	71.99	CHANGED	MAVVGlPGWIGpSAVsETGQRWMsuAApcLRlGlPsWMSsMAGRS+EIIHTLGADHNFNGQWFRDRCFEAGSAPIVFNITGDLVSYS+DVPLFFMYGDTPNEYVQLNItuGVsMYGRGGNG....sussusGosGGcsIQNDIGGRLRIsNsGAIAGGGGGGGG...su..suatsphssGGGGGRPFGsGG...suuthSGGsAS....louPGuGu...ussstasGGsGG-VGuuGGpuh...GtssppssGGAAGtAVhGSAPTWpNVGsIYGsRV	.................................................sGWlGSSAVsETGpRWMuuAuspL+L.usPhaMSQMsG+Shp.h.holGt...............................................................................................................................................................................................................................................................................................	0	0	0	0
+5096	PF05269	Phage_CII		Bacteriophage CII protein	Moxon SJ	anon	Pfam-B_7453 (release 7.7)	Family	This family consists of several phage CII regulatory proteins. CII plays a key role in the lysis-lysogeny decision in bacteriophage lambda and related phages [1].	21.30	21.30	21.30	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.11	0.72	-3.98	3	497	2012-10-04 14:01:12	2003-04-07 12:59:11	6	2	366	12	19	217	1	84.00	41	89.93	CHANGED	MspAS....TR+EAsRIESuLLN+IAhLGQRKlA-AlGlcESQISRWKsDWIPKhSMLLAVLEWGVsDD..-lARLAKpVAclLTKKKRPsC.TERSE	...................M..ss....pp+..c..ssRhEosLL.pLuhlsQ+shAchlGspESplSR.......s.......-...ah...hhu...hL..hA...aGhss-........hu+h.h+hshs.hl.....T.pcKtPss.sE...................................................	0	0	4	12
+5097	PF05270	AbfB		Alpha-L-arabinofuranosidase B (ABFB)	Moxon SJ	anon	Pfam-B_7464 (release 7.7)	Family	This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is  formed by 1,5-a- linked l-arabinose residues that can be branched via  1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses  1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and  polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains [1].	21.30	21.30	21.60	21.90	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.95	0.71	-4.49	11	334	2012-10-02 19:42:32	2003-04-07 12:59:11	8	53	174	16	174	358	3	131.80	27	13.91	CHANGED	lS.l+soossYssRYlsHsuoTlNTpVVSSuSussl+pp.......ASapVpsGLAsuu.....ChSFESsDsPGoYlRH..tNFpLhlsANDGoctFpcDATFCPpsGlsu..pGs.SlcSasYPsRYlRHYsNlLalsusuG...a-ssssFpsDsoFhlt	....................................................................................l......tt.....s.....s.hps.sss............p.........us.atl.s.s.G.....L...us.ss.....slShES..sshPGhaL.R.H......tsh.pltLs...t..s...-.u.o..shFppDAT.F..phpsG...hss..sGh..........ohcShs..hPs.p..alR..H.h.s.....h..lhlst..........ttst.aptcsoFhht...............................	0	38	89	139
+5098	PF05271	Tobravirus_2B		Tobravirus 2B protein	Moxon SJ	anon	Pfam-B_7517 (release 7.7)	Family	This family consists of several tobravirus 2B proteins. It is known that the 2B protein is required for transmission by both Paratrichodorus  pachydermus and P. anemones nematodes [1].	20.90	20.90	21.10	197.70	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.56	0.71	-4.40	4	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	3	0	0	13	0	117.70	63	47.08	CHANGED	ssDWuohWPNDpLFlsDhhpLVWFDhhsDhVchpHFsuQsssDLSsIPKuFlSFlDNRlPMCINHKGhVYIRVt.su--sYYQKFG-LDVSsFsDshLPPDh-FsFsKVshssscpl.	NGDWuoKWPND+LFlDDFGKLVWFDlLsDlVcIoHFVSQsPTDLSsIPKSFISFIDNRlPMCINH+GWVYIRVKh-u--VYYQKFGELDVScFGDShLPPDFEFsFsKVTssVD+pLV	1	0	0	0
+5099	PF05272	VirE		Virulence-associated protein E	Moxon SJ	anon	Pfam-B_6573 (release 7.7)	Domain	This family contains several bacterial virulence-associated protein E like proteins. These proteins contain a P-loop motif.	21.50	21.50	21.50	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.18	0.71	-4.84	10	1163	2012-10-05 12:31:08	2003-04-07 12:59:11	6	20	659	0	186	1048	243	191.70	28	33.69	CHANGED	YLcul..pWDGhPRl-ohFhD......aLGsEDspYsptso+hahhuuVARVa.....cP..GsKaDalllLpGsQGsGKSThlctL.GGc..WFoDo...lcshcsKDthptlpGsWIsEluELsuhs.Ku-lEsIKuFITRocDpaRssYG+pspsaPRpslhVGTTNccEaL+DsTGsRRFaPlpss.K..plsh....s-hhpt.h-QLaAEAhhhYcc	.............................................................th..tWD.Gh.pR.lpt.....hhhp.........hls.......s....p....s..s..t.......h.s......p......h....++ahluhlA..+...sh.....ps....ss..+...h...c..h..s..ll.L..h.G.s.Q.G.hGKSTa....h.c.....t..L....s..sp.......a.a.oDs........l.p...t..h.....p..s..+....-.s..h.....p....t....l..pt.h....hllp....hs.E.hsu.hs...ppp..h.p.tlKshlo....cphsphRhsYs..c..p.s.pchsRpssFlGToN.p..p.-......a..L.p.DtT.Gs.RRFhslpVp.s....hch..........c.................hpQlaApAh.h...t.................................................................	0	95	149	176
+5100	PF05273	Pox_RNA_Pol_22		Poxvirus RNA polymerase 22 kDa subunit	Moxon SJ	anon	Pfam-B_6584 (release 7.7)	Family	This family consists of several poxvirus DNA-dependent RNA polymerase 22 kDa subunits.	25.00	25.00	79.50	79.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.04	0.71	-4.65	10	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	43	0	0	34	0	182.10	69	99.44	CHANGED	MNpHNV+YLAKILCLKsEIh+cPYAlISK-llp+Yss-lcYGDLVTlITVpHKlDss+TVFQVFNESSVsYoPlEcDYGEPIIITSaLQpGHNKFPlshLYIDlVASDlFP+FsRLos-ElsllsSlLQsGDsK..poLKLPKMLETElusKILYHKDhPLKlVRFa+NNMlTGlEluDRuVlsVl	.MNQaNVKYLAKILCLKTEItRDPYAVIsRsVlhRYsTDIcYsDLVTlITV+HKIDohKTVFQVFNESSlsYoPV-DDYGEPIIITSYLQ+GHNKFPlNFLYIDVVhSDLFPoFVRLsssEssIVsSVLQsGDuK..coL+LPKMLETEIVsKILY+PsIPLKIVRFFRNNMlTGVEIADRSVloV..	0	0	0	0
+5101	PF05274	Baculo_E25		Occlusion-derived virus envelope protein E25	Moxon SJ	anon	Pfam-B_6633 (release 7.7)	Family	This family consists of several nucleopolyhedrovirus occlusion-derived virus envelope E25 proteins.	20.70	20.70	211.80	211.40	18.70	18.00	hmmbuild  --amino -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.15	0.71	-4.68	17	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	53	0	0	53	0	183.90	52	84.15	CHANGED	upS.uDSlQhs.p.GphsVK.hNss+lKslRlhaGD..NcISKlhVuEpPLoYs-IlDcGN+.VGsNsVFlGslp-shsss................sssssRsTuNFsIKQFKNhFIVFKsl-.ocIcpsssMlRYEu-uMVYsLIDuosoolP-.LRDV.....SYPIsVhTsNussQLhLKEWsYTQINDuGTLFlKNEKSFR	....spS.SDSlphssp..GphsVK.h.Nss+lKslRlhHGD.....N...KlSKlaVAE+PLoYs-Il-cGN+pVGsNsVFlGTl.-sussS...............s.sssssRsTuNFDIKQFKNhFIVFKsl-ssKIccsssMlRaEuDGMVYCLIDussoolP-..LR-V.....SYPIsVYTsNussQLhLKEWsYTQINDuuTLFlKNEKSFR.....	0	0	0	0
+5102	PF05275	CopB		Copper resistance protein B precursor (CopB)	Moxon SJ	anon	Pfam-B_6721 (release 7.7)	Family	This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every  organism. CopB serves to extrude copper when it approaches toxic levels [1].	20.80	20.80	22.10	20.80	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-10.93	0.70	-5.10	81	554	2012-10-03 17:14:37	2003-04-07 12:59:11	6	4	422	0	149	499	67	205.50	41	65.28	CHANGED	ssthhthlhhDcLEhptsc..sssu.hsW-spuWhGsDhsRlhlKoEG........Ehppuc..h--u-.sphLau+AIuPaWDhQsGlRtD..htss.s....sRsaushGlQGLAPYaFEl-ushaluccGcsuhRlEuEY-lLLTQRLILQPclEsshhup-DsppulGuGLosh-hGLRLRYE.lsRpFAPYlGVsapppaGsTADhsRspGccsspsphVsGlRhWF	...................................s..th.hhlllDpLEhppsc..ss.ss..huW-spuW.lGuDhsRlal.+oE.G...........EpspGc...sEsu-...sphLau+ulu..PaWDl.uGl..RpD........hps...u..s.........sRsW..A.AlGlQG...LAPYhFEs-uosalupsGpsuhRLcuEYDlLLTpRLILQPphEsshhupcDsppuhG.sGLoss-hGLRLRYE.lp.RcFAPYlGVsasppaGpTu-hs+tpG-.p....s....ppspalAGlRhWF.........................................	0	40	89	124
+5103	PF05276	SH3BP5		SH3 domain-binding protein 5 (SH3BP5)	Moxon SJ	anon	Pfam-B_6742 (release 7.7)	Family	This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk).  Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule [1].	23.00	23.00	23.10	23.50	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.60	0.70	-5.05	8	259	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	95	0	164	239	2	194.20	41	52.73	CHANGED	Es-E...lDPRIQtELE+LNpATD-IN+hElELE.......................................................................EA+spFRplLhEuscKLcsluKKLGssI-KARPYYEA+chA+pAQhEsQ+AAhcFpRAsplhsAAKEpVuLAEQpLhppsp..phDsAWQ..EMLNHATp+VhEAEpp+scuEspHpcps+thppApp+lppLEcch+RuIpKSRPYFEhKtpapppLEsQKtpls-LEtcVppAKssYosALRNLEpISE-IHppRpstu....ssuscpsus	.....................................................................................................................ht.plp.ELEcLNpuo-pINphEh....pL-.......................................................................-A+.ppaRplL..Eush+Lpt.sp+lG.p.s.l.-cu+PYaEA+phA+pup.EsQpAs.papRAsphhtAA+Ehl.........lAEQtlht..........cpt.....ph...DssWQ.....EMLNHATp+V.-AEpp+hcuch.HpcssthhptA.t+hptLp+p.L++uIt...KS+PYFEhKup.......a...Lcp...KtpVppLptplstA.KtpYp.AL+NLEpIS-pIHtpRpt..................s...........................	0	51	64	122
+5104	PF05277	DUF726		Protein of unknown function (DUF726)	Moxon SJ	anon	Pfam-B_6757 (release 7.7)	Family	This family consists of several uncharacterised eukaryotic proteins.	22.60	22.60	22.80	23.00	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.19	0.70	-5.56	9	559	2012-10-03 11:45:05	2003-04-07 12:59:11	7	18	287	0	381	563	32	271.90	31	41.08	CHANGED	++hKRhhhlGLAsluGuhlIGlouGLtAPlluAGlushh......GssGsss...hLuus.uGsA.llsuhhushGAtlsuhtMp+RsuslcsFpFhPLpsspp............tslhVslss.h.hus.c-lptsWpsLs.s......s-hYuLtWEschLhphGpsl.slLhStshshshQpl.LttTl....................LsuLhuAlpWPhuLhKlu.llDNPWslshcRAhpAGchLA-sLhsRsh.GhRPlTLlGaSLGARlIa.CLhpLuc+.cthGllENVllhGsPssschc.WpphRoVVSGRhVNsYscsDWlLuaLaRssust..pluGhusls...hpslENlDsoslVpGHLsYpcphsplL+tlshc	..................................................................................................t....+hhhhGhAslsGuhllul..ouG.LhAPhluuuh...ushh.............Ghsuhsu.................lus.........h....u.t...s.......hhss.hshhG.uths.s.hhhtphh.t.tlppFthhslttstt....................................................plhlsl.h...h........t.p...p.shhhPa.p.hlt....................t-.aslhWEsphLhphGpsl.phl.h.st.h.h....s..s....hpph.lt.Tl................................................................................hssl.huul.hP.h....s..L.h.p.hu...h.lDNsa..slshs.RuttsG.thLA....c....s....Lh...p...+t......GpRP.lT...LlGaSLGuRlIa.CL.p...L...Ap..........c......t......shG....l..lps.Vhlh.G.uPhss..........p....t....pp....at..........h....+.pVV...u...GRhlNsY.....s..psD..alLu..................h...laR.........t.s.....t...h.........th....t..........lu.Gltslp..........t.......l-..Nhshoph.l.tu.Hh.pY.........hstlLpthth.............................................................	0	135	225	323
+5105	PF05278	PEARLI-4		Arabidopsis phospholipase-like protein (PEARLI 4)	Moxon SJ	anon	Pfam-B_6763 (release 7.7)	Family	This family contains several phospholipase-like proteins from Arabidopsis thaliana which are homologous to PEARLI 4.	27.90	27.90	28.30	28.00	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.63	0.70	-5.02	6	68	2009-09-11 21:08:31	2003-04-07 12:59:11	7	5	8	0	42	67	0	216.70	24	49.53	CHANGED	s-ptslhLFP-lhhs.psp.sScs.........................................................pp.ppptppEssEL..........................-hpShhS-Sa..VSVGpY+VRuSVSoTLQuIlDKHGDIAusSKLQShuTRSYYLEsLAuVVhELpSTPL+pLocsRVtEMlAVVKDlESVKIcVGWLRoVLEElsEAscaastpEssssEKEspE+clhhcKpEMEtppp-Lsc+EKElKEhRc+lpEhsu+LG-LEMKRsRL-KphshhuSKVEKF.cGcohlcc	....................................................................................................................................................................................................................................................................................h..s-sh.....VpVstYpVctShsshLptIlcKHGDIuusscLpShphRShYLEsLssllp-L..p.poslc.pLocsclp-hhuslpDl-ssplcVuWL+s...tLsE...lh..-s..hchh.......s.phctschc+ctpc+c.lpttcpEhEt...pp-LtphEpcht-hptph........http.....hsphp....th......h..p...........................................	0	14	24	27
+5106	PF05279	Asp-B-Hydro_N		Aspartyl beta-hydroxylase N-terminal region	Moxon SJ	anon	Pfam-B_6767 (release 7.7)	Family	This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin [1]. Aspartyl beta-hydroxylase catalyses the post-translational hydroxylation of aspartic acid or asparagine residues contained within epidermal growth factor (EGF) domains of proteins [2].	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.86	0.70	-4.52	9	236	2009-01-15 18:05:59	2003-04-07 12:59:11	6	14	40	0	49	199	0	177.80	40	49.29	CHANGED	NGR+GGlSGu.SFFTWFMVIALLGVWTSVAVVWFDLVDYEEVL...............GKL.GlYDADGDGDFDVDDAKVLLG....lK-+.hsc...................................t.s..cEt-shsc.Ettlshctphpplc-ElKEQlpplhcchVhsc.......pp.ct.stE.p.-tc+hhhtsDsD-phcs.tssts+EEhEt.h..Ech.p.t.....cEhsscpcsscspEsVp..cstch+tcsscVs.psh-cp.....................pt.h-pt....Ech.h.ssEcppcsP	............................................ts..ShhoWhhVIALLGVWTSVAVVaFDLVDYcpVl..........................................GKL.ulYD.ADGDGDFDl-DAKVLLs..............hppt....p.........................................................t......h...tt.....th.t.p.....tc.p.t....t....c....................................................t............pt..............................................................................................................................................................................................................................	1	3	7	23
+5107	PF05280	FlhC		Flagellar transcriptional activator (FlhC)	Moxon SJ	anon	Pfam-B_6773 (release 7.7)	Family	This family consists of several bacterial flagellar transcriptional activator (FlhC) proteins. FlhC combines with FlhD to form a regulatory complex in E. coli, this complex has been shown to be a global regulator  involved in many cellular processes as well as a flagellar transcriptional activator [1].	20.60	20.60	21.00	21.40	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.17	0.71	-4.80	23	831	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	727	2	135	359	15	173.70	64	90.40	CHANGED	Mu..pKS....llsEucpIpLAhELIpLGARLQlLEoETsLSR-RLl+LYKEl+GsSPPKGMLPFSTDWFhTWpPNIHSSLFhNIYpaLhcpussssl-AllKAYRLYLEplst.pphEP.....l.......LSLTRAWTLVRFhDusMLphopCspCGGcFVsHua-.ppsaVCGLCpPPSRAGKo++suspt	..........................................................MuEKSIVQEA+DIQLAMELIsLGARLQMLES.ET.Q....LSRGRLI.KLYKE..L.R..G....SP...P.P.KG..M.LPF..S..T..DWFM..T..W.EQ.N.l..HASMFh.NAapFLL..Ko.....G..h.Cs..GV...DAVIKA..YRLYLE....Q..CPp.....s..c..-sP..L.......LALTRAWTLVRFVE......S......G.l......LpLSuCNCCGGsFI..T.H....A..H....Q....P.s.s.SF..sCSLCQ...P....PSRAVK+RKLSp.ss...............	1	10	53	95
+5108	PF05281	Secretogranin_V		Neuroendocrine protein 7B2 precursor (Secretogranin V)	Moxon SJ	anon	Pfam-B_6776 (release 7.7)	Family	The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia [1].	25.00	25.00	44.70	38.80	20.10	22.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.66	0.70	-4.95	12	117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	88	0	64	114	0	200.70	45	85.95	CHANGED	hh......tlL.......hhsl.........tsAh.shsP..phhDplS..cschthhhcush-.................p.t.u..c.Ea.tHpu..LhG.QplpGGAtEG.p.........shst.hossslP.......uYssPPNPCPlGhT.tsDG..ClEsh.sTA-FSRcaQspQchh.DsEH.hasss.............................................sphp+sLlh+K..h+stp................tpcppcps.NPaLQGp+Lc.lsAKKsssph.	......................................................hhhh.......h......th.............sssh..uhss.......cssDpVS..-s-l.....pRLh+.GshE...........................phGlup.csEYssHpu...LhGsQpIp.GG..A...pE............GhQ.................+Lu......P.....G......N........IPN..ls....sEhT.scsl.P...................uYssPPNPCPl....GhT.scDG...CLEshssTAEFSREa....Qhp..Q....chh.DsEH.as.sh............................................................uphsKpLlhcK...h+stt...................Rpccsl.NPYLQ...G..p+.Lc.lsAKKus.hh.p........................	0	18	23	43
+5109	PF05282	AAR2		AAR2 protein	Moxon SJ	anon	Pfam-B_6782 (release 7.7)	Family	This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth [1].	20.40	20.40	20.60	23.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.37	0.70	-5.53	41	321	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	253	2	227	311	4	325.70	23	83.00	CHANGED	h............sslllhslP.ts.....hlGIDhhoassssp..F+GlKtlPs..G..hHFlahs.........................................................ppsshuhRhGhahhhp.........................tsclhlh+WspppEshh..ps...........pt....................pthptpspl.tphpph..LssYPh.........................................cshp.pWtsLT.shIs........pllp+lpshs........................................hhlsstpssppcpp...................................ttpptscpt.thtt..........................................................................psplpFs.l.....cpphppusss...........p-lTctshD+SahLppll................................pphpsp.ttlLGELQFuFlhhl.hhtsasuhpQW+pLlpLlssu.pphltp...ptph.....................ahpllclLhhQLt.............chsp-hhhD......hhppstFlt.hl........................htttltpphcplcshlppcashcl.........cs	...........................................hh..ssslllhslP.to........hGIDh.sapsssp.....F+GlK.lPP..G...hHFl.ahu.........................................................t...tphu.Rh..Ghah.hp.............................tp.lhlhcWsttpEpl....t.....................pt....................................................ch.t.tsph.tphcph...LssYsh.........................................pphp..pWhpLo.shl.o........shl..p+lts.s...ht........................................hls.sttt.tptcpp.........................................t...tp...h..................................................................................................tpphpFs.l........pphh.tssss...........t-hTptshDp...ShhLppll...............................................................tphtt...s..tplLGELQauFlshl.hh....tshpuhppW+.pL.l.p.Ll...........hps.ptsh.h.p....ctth..........................ahphlp.lLhhQLt........................phsp-hhh-.................hsts.shltphlp..................................................................t.........h..t.....t.....tl...hpthtphpthlpt..phtWph..t......................................................................................	0	74	122	184
+5110	PF05283	MGC-24		Multi-glycosylated core protein 24 (MGC-24)	Moxon SJ	anon	Pfam-B_6825 (release 7.7)	Family	This family consists of several MGC-24 (or Cd164 antigen) proteins from  eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many  normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing [1].	25.50	25.50	25.80	25.80	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.58	0.71	-4.50	4	165	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	61	0	82	152	0	116.60	30	77.58	CHANGED	huRphh..hAAhCh.usLClLustps.sttssssths.hssssoshsssls.sT....psCE..phNsC.pClNsoh.ssohCsWhpCpsE..saCSutstV....usCp.tNoT-SCSs.sss.......sVsT.puTstPshps.uso.........sosppsTosssTNsTVTPssp.sRKSTFDAASFIGGIVLVLGlQAVIFFLYKFCKS	...................................................s...........................................................................................................................................................................spot.....ss..s................................................................................................s.tt....s.o...p...s...t...s.s...sT.s.oPs..s.........s...+...p....st......FDuuSFlGGIVLsLul.Alhahhh+Fh+u........................	0	8	13	28
+5111	PF05284	DUF736		Protein of unknown function (DUF736)	Moxon SJ	anon	Pfam-B_7619 (release 7.7)	Family	This family consists of several uncharacterised bacterial proteins of unknown function.	22.00	22.00	22.40	22.30	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.37	0.72	-4.21	66	445	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	185	0	238	454	42	101.00	34	87.91	CHANGED	ssI.GpFs...psp.suapGplcTLolsscl.plVPsps..ss-...sAPDaRlhsu.........ss.ElGAuWp+pupc....up-YlSlpLDDPsF.stPlhAsLhp...sp-sctt..asLlWsR.Ppc	.................sI.GsFs...pss..s.uasGplpTLsls.sch..pllPspp..ss-...pAPca..R..lhsu..........ssElGAAWp+pupc....Gc-YlSlpLDDPuF.suPl..hAsLhp....s-css.t...asLlWsRs...........................	0	36	145	190
+5112	PF05285	SDA1		SDA1	Moxon SJ	anon	Pfam-B_6906 (release 7.7)	Family	This family consists of several SDA1 protein homologues. SDA1 is a Saccharomyces cerevisiae protein which is involved in the control of the actin cytoskeleton. The protein is essential for cell viability and is localised in the nucleus [1].	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.31	0.70	-5.15	38	397	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	283	0	294	403	7	256.40	28	42.13	CHANGED	Ms....EsLLQDLspYK.....sSK.-KuVhMAARuL...........luLYRE........VsP-hLp+KDRGK.sAuhulpssctp.........taGcpps.sssI.GlELLtca.......t..ct-pu...ss-s-sDsp.............W...............................ps...t-ss-ssDs..cGpWlsVpsD...p..........................................................oDsEDEcp............................t..t.t.....p.phpsccpsppsppptp-.........................................stcpphspluoo..RILTPADFtKLpELRtptul..sphhsttt......................pcpp--hlsuscIEuhsKht..Kps+EERlApspEGRp-RpcatS....+Ks+Kcsts.pSTTN+EKpR.+KNFhM.hl+K.ts+uKpKpSlp-+ppsLRsHlt+p.....K+tt	.............................................................................................hscpLLpDLs..Y+.....pp+.sKsVhhAA+uL...........lpLaRp........lsPphLt++.RG+..sphthp.tt..t.................aGp.p..hs.l...GhE.l..Lt.t.............ttt.......tpptp.p-tt.............h..................................................................tt...ppp.ppDt........psth.h...s....spps......................................................................sDp-p.pt.......................................................................t....t.....t.tt....t............................................................ttttthttlsss..+lL.T.tD.ht+lp.hphptth...pth.ttt..............................................tptttchls.pplpt.hch.....Kts+.......-pRlttshtG+psRtcat................+tp+..t.h..tSpoN+cKt+.pKsh.M..h...h.tp...s+sKt....ph.S.hh.cpp..hhp..tt..+t.....p...t.................................................................................	0	106	161	235
+5114	PF05287	PMG		PMG protein	Moxon SJ	anon	Pfam-B_7710 (release 7.7)	Family	This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages [1].	29.00	29.00	29.40	29.10	28.10	28.90	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.55	0.71	-4.47	15	251	2012-10-03 03:07:01	2003-04-07 12:59:11	7	10	30	0	129	302	2	146.40	33	89.87	CHANGED	MSYsCsSGNaSS+ShtsphphPsoSsso..shPoslshssslCoPSopQhuSolhcsCQETCsEPhpCQssssp..............................sssCQsoCapPpsSslsuPCpoThuGsluFsSS..SCpshuh..........tSpsC.slG.sGSsuapslstsossh.shshhot..aC+Pshh.........uS+oh.Qs...............oCapPsCuSuh	............MsasssotshSopSh.....tshhhhPsssss.s...hssslshtsshh.P.S...oh...Q...hso.LhssC...QETChEPssCp.oss................................spsCQ..ss......C..pPp.....sh...h......ssP.Cps.sh..s.tsh..........u.asSs..........uCps.huh..........hopss.slu....ssS.....sshpslshh.sp.sh.s.s.hst......hCpP..h....................s.psh.ps................s.....h.................................	0	14	14	42
+5115	PF05288	Pox_A3L		Poxvirus A3L Protein	Moxon SJ	anon	Pfam-B_7718 (release 7.7)	Family	This family consists of several poxvirus A3L or A2_5L proteins.	25.00	25.00	98.30	98.20	22.20	20.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.29	0.72	-4.24	12	91	2009-09-11 10:15:31	2003-04-07 12:59:11	6	1	41	0	0	44	0	66.90	66	95.24	CHANGED	tYplsLcPP++C.SpC.sNLh-alp-Dccsl+hhLtSQPpKhplLKpFLshsRNKphhhKILDpEl+RVLs	..Yph.lp.PK+C.S.pChsNLhcalsEDuNs.I+hlL.SQPpKLKVLp-FLushRNKpFlYKILD-ElRRVLT.	0	0	0	0
+5116	PF05289	BLYB		Borrelia hemolysin accessory protein	Moxon SJ	anon	Pfam-B_7729 (release 7.7)	Family	This family consists of several borrelia hemolysin accessory proteins (BLYB). BLYB was thought to be an accessory protein, which was proposed to comprise a hemolysis system but it is now thought that BlyA and BlyB function instead as a prophage-encoded holin or holin-like system [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.27	0.72	-4.22	3	123	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	28	0	5	92	0	102.00	77	87.44	CHANGED	MKLSKNNLELGLTSLSTLIDIFSKFED.EFDEsAHKGFFLVYELYSHYKLIYTANMERLESALTPsIscTLAPINEKINQCIDLVNSDEKNLKISNDLKFNcEGKP	.......MKLSKDNlELGLTSLSoLIDIFSKFED.EFDEIAHKGFFLVYELYSHYKLIYTANMERLESALTPs.IstALAPLNEKINQCIDLVNSDEK.NLKISNDLKFNQEGKP..............	1	4	4	4
+5117	PF05290	Baculo_IE-1		Baculovirus immediate-early protein (IE-0)	Moxon SJ	anon	Pfam-B_7745 (release 7.7)	Family	The Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV) ie-1 gene product (IE-1) is thought to play a central role in stimulating early viral transcription. IE-1 has been demonstrated to activate several early viral gene promoters and to negatively regulate the promoters of two other AcMNPV regulatory genes, ie-0 and ie-2. It is thought that that IE-1 negatively regulates the expression of certain genes by binding directly, or as part of a complex, to promoter regions containing a specific IE-1-binding motif (5'-ACBYGTAA-3') near their mRNA start sites [1].	33.10	33.10	33.10	87.10	32.30	33.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.13	0.71	-4.45	14	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	40	0	0	40	0	136.70	43	54.30	CHANGED	lpalsspspapashaIFlPYlKQLppIlpLFhNDaCCsKlVKphtssLssLlscSt+hL+sI+hhNcRhQVlNVFh-s..lYpCNICpDTSsEE+FLKPNECCGYpICNhCYANLWKaso..lYPsCPVCKTSFKSSssssppt	...................t.s.a.hNhalFlPYlKQLptllch.FpND.a.CCtKllpshthtLspLlscstchlcpIcshN+plpVhNVFh-s..sLYECNIC+-sSs-E+FLKPsECCG.YsICNhCYusLWKass..haPhCPlCKTSFKssp...........	0	0	0	0
+5118	PF05291	Bystin		Bystin	Moxon SJ, Wood V	anon	Pfam-B_7767 (release 7.7)	Family	Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy [1]. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localised in the nucleus [2]. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesise 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits [3].	28.00	28.00	28.20	30.20	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.76	0.70	-5.48	21	359	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	301	0	250	363	3	287.10	46	68.65	CHANGED	Fhs..ps..............spoLuDhIhpKIpE+-sph..........ptthtptps..hP..thsP+Vl-lYcpVGplLS+Y+SGKLPKAFKllPslssWEplLhlTcPcsWTPpAhatATRlFsSshpsptAQ+FhphVLLsRVR--Ip..EsKKLNaHLYpALKKALYKPuAFFKGlLFPLspossCTLREAhIluSVlsKlSIPlLHSuAALh+ls-h.........-asGssShFI+lLL-KKYALPY+VlDulVhHFhRFps.p..................cpLPVlWHQuLLsFsQRYKsDlop-Q+-tLlcLl+t+sHh.tIoPEIRRELhsupsRssp.s.sth	.............................................................t...phsLADhIhpKIp-+psp.................tt...h.t.t.....s.sh......s....plss+Vl-lYptVGplLo+Y+SGKLPK.sFKllPs..LpsWEp..lLhlTcP-p............WospAhYpAT.RIFsSshpsphAQ+......FhshVLLsRlR-DIt...EpK..............+LNhH.LY.........pALKK..ALaK.PuAFF.KGlLhPLs.poGsCTLREAhIluSlls+sSIPlLHS.uAAlh+ls-h...........-.asGss.olFl+lLL-KK...............YALPY+VlDulVhHFlRFcspp..................................cpLPVlWHQuLLsFsQRYKs......Dls.p-Q+-tLL-Llchp.s..H..pIsPEIRREL.sutsRs.....................	0	92	141	208
+5119	PF05292	MCD		Malonyl-CoA decarboxylase (MCD)	Moxon SJ	anon	Pfam-B_7770 (release 7.7)	Family	This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidised. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK) [1].	19.00	19.00	22.20	19.60	17.90	17.80	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.18	0.70	-5.76	3	443	2009-01-15 18:05:59	2003-04-07 12:59:11	6	9	296	2	221	458	837	259.70	34	71.11	CHANGED	MLsEKFGsscEKLspAIshY..sKs-pthIpl+suAssSRscLl+slNchPGGTu+Vs-MRpplLA......SKsooSth+sLDlshs-lhsSWFSLGhLcLE+LsWooPu.ILpKltEYEAVH.ltGhp-hR+RLuPLsRRCFuF.HEsLAcEPLVFVEVALs-oVAcoIt-lhccGt.phpt--tTTAlaYSIossQPGLuGIsLGNFLIK+VlTcL+KDlPuVoTFuTLSPIPGFtpWLl+pLpupScasp......................pE+sl.hlSD.Sppt.NthEssETLLuVcss-WsTcK+pLsslE+ILMhLCARYLLsEK+.cG+ALDSVANFHLpNGAcLERLNWhGDRScKGIpQSaGIMVNYlY+	..........................................................................................t..........................................................................s.h.tlhpph.......s...t...uht.Ll.thRtclht.......................t......tlt.l-tthpph...hsp..WFshuhL.Lc.ls..W.p.o.PsplLpKlhtYE...........AVH.....l.p.s.W...Dl+pRlts.......RRCauFhHsthst..................-PLlhlcVAL.spthsssl..t....l.......l.....t...t....................t............t................................t........p..........p...s...s..s.AlFYSISssQ.GLtGlshGshLIKpVlppLp.........p.........-h......Pp.........lppFsTLSPlPGFhpWL.......t........................................................................................................................................................................................................................................................................t.h.p..hhthsAhYl..h..tt+p....p.....G....h..s.h....sPVApFHLtNGAhl.c..lNahuDhS.+GhppShGhMVNYhY......................................	1	76	127	174
+5120	PF05293	ASFV_L11L		African swine fever virus (ASFV) L11L protein	Moxon SJ	anon	Pfam-B_7869 (release 7.7)	Family	L11L is an integral membrane protein of the African swine fever virus (ASFV) which is expressed late in the virus replication cycle. The protein is thought to be non-essential for growth in vitro and for virus virulence in domestic swine [1].	25.00	25.00	159.30	159.20	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.77	0.72	-3.85	2	12	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	0	0	10	0	77.30	92	93.55	CHANGED	MLEPlLVMAPIPLlLIFLYSYFKIKLHKLITIALFLGCLFFILRDFCFPPMLWp.LpNhT.shNshLGNpSF.VpCpp	MLEPILVMAPIPLVLIFLYSYFKIKLHKLITIALFLGCLFFILRDFCFPPMLWTQLHNITSSIN.ILGNNSFQVKCNp.	0	0	0	0
+5121	PF05294	Toxin_5	toxin_5; 	Scorpion short toxin	Moxon SJ	anon	Pfam-B_7892 (release 7.7)	Family	This family contains various secreted scorpion short toxins and seems to be unrelated to Pfam:PF00451.	25.00	25.00	26.80	26.50	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.27	0.72	-3.74	6	25	2012-10-01 23:31:40	2003-04-07 12:59:11	8	1	11	2	0	29	0	32.20	66	72.07	CHANGED	CsPCFTTDPpMppKCpcCCGG+..GhChGPQCLC	ChPCFTTDPsMupKCp-CCGGp..GKCaGPQCLC.	0	0	0	0
+5122	PF05295	Luciferase_N	Luciferase; 	Luciferase/LBP N-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_7906 (release 7.7)	Domain	This family consists of a presumed N-terminal domain that is conserved between dinoflagellate luciferase and luciferin binding proteins. Luciferase is involved in catalysing the light emitting reaction in bioluminescence and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme and therefore switching off the bioluminescence function. The expression of these two proteins is controlled by a circadian clock at the translational level, with synthesis and degradation occurring on a daily basis [1]. However This domain is not the catalytic part of the protein.  It has been suggested that this region may mediate an interaction between LBP and Luciferase or their association with the vacuolar membrane [2].	25.00	25.00	104.80	104.10	20.80	16.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.63	0.72	-4.18	13	14	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	8	0	0	14	0	81.60	58	8.43	CHANGED	MAs..QLspFLsN-AKlDs+VluYMT+pLpL-SVSDFANYWTSsEYE+GVQDDIlupVusFpss.SKPsuKlQlARLRAAW+uAQ	MAt..pLspFLss-AKlDs+VluYMT+pLpL-SVSDFANaWTosEYE+GVQDDIlupVssFpss.ScssuKlQlARLRAAW+uAQ.	0	0	0	0
+5123	PF05296	TAS2R		Mammalian taste receptor protein (TAS2R)	Moxon SJ	anon	Pfam-B_1498 (release 7.7)	Family	This family consists of several forms of mammalian taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia and are organised in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.02	0.70	-5.53	20	1248	2012-10-03 04:04:29	2003-04-07 12:59:11	8	3	92	0	394	2541	0	286.50	29	96.76	CHANGED	Mhssh.slh.hllhlsEhllGlluNuFIsLVNsh-Wl+p++lSslDhILhuLAISRIsLlhllllssahhlhhsshatsuthhphlshhWhhhNphSlWhAThLulFYhlKIAsFSHPlFLWLKhRlspVlsal...LLuolllsh..lsplhpshp...........phppNoThphchpchphhhshlhhp..lsshlPFllsLlShhLLIhSLh+Hp+pMppsuoGhRDPsTcAHspAlKsllSFllLahsYaluhllphhshhhscsplhhhhs.hhshhYPssHShILILGNsKLKpshhplLtph+	.......................................................................................................................hh..h.hlh.h.hthhlGhhuNuF.I..s.lV.Ns.h.-W..l..+..p..p.c.l.u..s.sDhILhsL.ulSR.lh..Lh...h..l.l.hl.....sh.h.hhh.h..ss..hh.s..h.p..h...h...hphh.t.h.h.W....hhhN.ph.olWhuos.LSl.F.Y..hl.K...I..A...s.F.o.....p...sh....F.L....a..L.K.....h...R....l....s..p..l....l.....s......h.l........L.L....G.....s..l...l...h.s..h....h..........h..h...h....l....s...h.....t..h.....p.........h....h...h..t......t.h....................php.p..N....h.....T...h......p...........h.........p......h....p........p....h.....t.....h....h..............h.h..hh.............ls.s...h....l....P....F..h...l........h....L.......l....S...h..h..L.......L.......lh...S.Lh..+...H...h+....p...M....p....h....p....s....p....u....s....p.....D....P....S....s....c.A.H.....l..+...........A....l+....s....l....l....S....FL....l....L..a....h.l.....a...a......l....u....h..h....l..s..h..h....s....h....h....h..............p...p...........p...h...h..h....h..h...s...t...h...l.....h.h...h..a.PusH.S.hlL.I..h.uNsK.L+pshhphh....h.................................................	0	26	90	163
+5124	PF05297	Herpes_LMP1		Herpesvirus latent membrane protein 1 (LMP1)	Moxon SJ	anon	Pfam-B_5174 (release 7.7)	Family	This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N-terminus and a long cytoplasmic carboxy tail of 200 amino acids. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high  lymphoma rates in immunosuppressed monkeys [1]	26.00	26.00	26.30	29.00	25.20	24.10	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.39	0.70	-5.53	2	1117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	10	3	0	569	0	128.40	64	101.97	CHANGED	ME+DLERGPPGP.RPPhGPPLSSSlGLALLLLLLALLFWLYIVMSsWTGGALLVLYSFALhLIIIILIIFI.RRDLLCPLGuLsLLLLMITLLLIALWNLHGQALYLGIVLFIFGCLLVLGLWIY.LEILWRLGATIWQLLAFhLAFFLslILLIIALYLQQNWWTLLVDLLWLLLFhAILIWMYYHG.RHoDEHHHDDSLPHPQQATsDSuHESDSNSNEGRHHLLVoGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPQDPDNTDDNGPQDPDNTs...........DNGPHDPLPHNPSDSAGNDGGPPpLTEEVENKGGDRGPPSMTDGGGGcPHLPTLLLGTSGSGGDDDDPHGPVQLSYYD	.................................................................................................................................................................................................................................................................................................NLtA.uGGP.sNuPQDPDNTDDNGPQsPDNTDD.....NuP.....QsPDNTD.........DNuP......QsPDN...................D...NGPHDPlPpsP.sDuAGNsuGPPpLTEEVENK.GGDpGP...PsMTDG..........G..........G..........G.....c..........s.H............................................................	0	0	0	0
+5125	PF05298	Bombinin		Bombinin	Moxon SJ	anon	Pfam-B_5347 (release 7.7)	Family	This family consists of Bombinin and Maximin proteins from Bombina maxima (Chinese red belly toad). Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumour cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 have been found to be toxic to mice. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides [1].	21.40	21.40	21.50	21.40	20.30	18.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.79	0.71	-4.72	3	225	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	4	1	0	219	0	135.80	84	98.03	CHANGED	MNFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRGIGsKlLGGlKTAlKGulK-LAS+alNGKRTAE-HEVMKRLEAVMRDLDSLDHPEEASERETRGFNQEEIANLFTKKEKRILGPVLSLVGuALGGLIK	.....MNFKYIVAVSFLIAS.AYARSVpNDEQSLSQRDVLEE.ESLREIRGIGGKILuGlKTALKGAAKELApTYlptKRTAE-.HEVMKRLEAVMRDLDSLDaPEEAoERETRGFNQ-EIANLFTKKEKRILGPVLGLVGsALGGLlK....	1	0	0	0
+5126	PF05299	Peptidase_M61		M61 glycyl aminopeptidase	Studholme DJ	anon	Merops	Family	Glycyl aminopeptidase is an unusual peptidase in that it has a preference for substrates with an N-terminal glycine or alanine. These proteins are found in Bacteria and in Archaea.	21.30	21.30	21.70	21.60	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.59	0.71	-4.14	10	668	2012-10-03 04:41:15	2003-04-07 12:59:11	7	4	574	0	253	702	215	119.60	40	20.25	CHANGED	.tsthsLlAHEahHuWNsKhhRPA-Lhs.sacpsstssLLWlaEGpTpYaGhllssRoGlhopcpsLctLAtshuphhs.psGRtapolp-oohDs.hlphtRspshsshspppsYYocGtllh	..................tphLuLsSHEYFHsWNVKpl+Psshts....aDhspEsaTphLWhaEGhTSYYDcLhLhRuGllotcpYLchLupslsph.p..ssGRh.hQolu-SSa-A.WhKhY...+...tD.p.Nus...Ns.h.l.SYYsKGuLl.u.................................	0	76	165	215
+5127	PF05300	DUF737		Protein of unknown function (DUF737)	Moxon SJ	anon	Pfam-B_6933 (release 7.7)	Family	This family consists of several uncharacterised mammalian proteins of unknown function.	23.20	23.20	23.60	23.80	21.70	23.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.18	0.71	-4.33	21	182	2009-09-10 21:09:58	2003-04-07 12:59:11	6	3	44	0	74	148	0	140.90	33	75.13	CHANGED	hDEpEplpVl+GIRLSEsVlsRMKEsSsPsstpp..ss.ssus.............................................................sspppl++tssppht.uLcps+ttoppp.sth....hppt.hKRhcpEQhhlQ-EluRlhc+E+pAAp-pLspulLRE+susccERt+AppL.......ARpLE-+EtEL++pDsFYKEQLuRlEE+suEhYKlToEQaHcAAocsEu+hK	...........................DEp-plpllpGl+L.S-sVlpRM+-s.s..ss.t........................................................................................................................................................................................................................t..ttp.........pp..tt..pttp...............................cthtp............+...hppERtuu..........p....c.p....hptul.pc+hpspcEp.cuthh........A+pLpp+-t..lpp.-saY+EQltplEc+s.phY+.osppappAApchcsph+...............................................................	0	5	13	32
+5128	PF05301	Mec-17	DUF738; 	Touch receptor neuron protein Mec-17	Moxon SJ, Pollington JE	anon	Pfam-B_6943 (release 7.7)	Family	Mec-17 is the protein product of one of the 18 genes required for the development and function of the touch receptor neuron for gentle touch. Mec-17 is specifically required for maintaining the differentiation of the touch receptor [1]. This family is conserved to higher eukaryotes.	21.20	21.20	21.20	21.40	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.44	0.71	-4.17	5	201	2012-10-02 22:59:21	2003-04-07 12:59:11	6	2	118	0	116	212	3	110.50	48	33.85	CHANGED	SDc.QllYlhtDcsA..uu+utlhGLLKVGpKcLFLaDsptsppclEps.CILDFYVHEScQRsGpG+cLF-aMLpcEpsos+QCAlDRPSsKLLuFLuKHYGLc+sVPQuNNFVLaEGFFsc	.................................ppphhYlht-sps...ssp..Gsl..lGhLKV.....GhK+LFlh..............Dp.ptt.p.p.E.hc....sh..ClLDFY......lHEShQRpGhG+cLFpaMLpcEpl.p.P....p..plA.lDRPS.KLLtFLpKHYsLpph..........lP.Qs.NNFVlF-sFFt........................	0	50	61	93
+5129	PF05302	DUF720		Protein of unknown function (DUF720)	Moxon SJ	anon	Pfam-B_6980 (release 7.7)	Family	This family consists of several uncharacterised Chlamydia proteins of unknown function.	25.00	25.00	122.80	122.30	23.50	20.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.79	0.71	-4.38	6	105	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	34	0	13	42	0	127.40	45	76.02	CHANGED	lYFsI.shLh.SVtsspashuIhA..LQ-NTshQQphspEhhplphlpVPchpKpDs.........Nps.IQshQosNQpIoAsRQhIQppLSuApQpAQs.ppslNosss...QlLQsssALlpTLppl.olhANL	....hYFsI..hLhpSVtlsQpslulhAppLQ-NTstQQpLNpEpsplpassVPcstKpsp.........sps.IQsVQssNQsloAsRpsIQspLSuApQsuQlIpSslNTNsNIhQQlLQssoALlpThsplsSllANL	0	3	3	10
+5130	PF05303	DUF727		Protein of unknown function (DUF727)	Moxon SJ	anon	Pfam-B_7004 (release 7.7)	Family	This family consists of several uncharacterised eukaryotic proteins of unknown function.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.33	0.72	-4.26	10	194	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	117	1	136	179	0	97.50	31	24.97	CHANGED	shclEApAsVs-ltFuVspIsV.ScpLPpss-lsYlNVcThEuspYClELTppGaRlVSppaDplssc..............spltlsopYaETlYuLLDsISPsYREsFG...spLsQ+LccLp	.........................................................EA.uhlp-l.htVtph.l...Sp.L.pss...DlhYlNlpThEsppaClclo.p.pGa+l...su.p..hDphssc.............................p.s.tha-..TlhsLLsplSPta+...csFu...ptLhp+Lpt..........................................	0	46	70	111
+5131	PF05304	DUF728		Protein of unknown function (DUF728)	Moxon SJ	anon	Pfam-B_7223 (release 7.7)	Family	This family consists of several uncharacterised tobravirus proteins of unknown function.	25.00	25.00	117.50	117.10	18.10	17.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.51	0.72	-3.86	3	35	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	8	0	0	27	0	132.70	84	97.52	CHANGED	KCALssC..EVssQuNchTCSMKHANKYNRaLA-KauVKRKCECsNCGWFPAIpVpsDalEVYFCCGMKHLpKC+...............................ScNPKKccR....LNTPKRLFRDDVDFGLstLFu	....TCVLKGCVNEVTVLGHE.TCSIGHANKLRKQVADMVGVTRRCAENNCGWFVClIINDFTFDVYNCCGRSHLEKCRKRhEARNREIWKQIERlRAEcs.sTVKKS+NSKsSKKcFKEcc-FGTPKRFLRDDVPFGIDQLFA.	0	0	0	0
+5132	PF05305	DUF732		Protein of unknown function (DUF732)	Moxon SJ	anon	Pfam-B_7356 (release 7.7)	Family	This family consists of several uncharacterised Mycobacterium tuberculosis and leprae proteins of unknown function.	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.66	0.72	-3.93	65	1009	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	197	0	174	553	1	102.60	25	72.21	CHANGED	thhusssuhsu...........huhAAP.A......pA..........s..D.................s...sFLssLp.psGIs..as..ssstAlthG+tVCstlsp.Gt........shspllsplttp.ts.shs...........tpAuhFsshAhssYC....Pphhsth	..................................................................................hs...hhhhshhuh..........hshAuP..A..............pA.....s..................sh..D..................................s.....sFL...ssLp..pt..Gls.......as...........sssp..u...lshG+.tVCptl.ss..Gt.............shtpl......ss...t..l..tp....p.......s..shs..............ppAst.F.s....s.h.AhptY..C....Pphht..h.......................................	0	22	84	143
+5133	PF05306	DUF733		Protein of unknown function (DUF733)	Moxon SJ	anon	Pfam-B_7392 (release 7.7)	Family	This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.	25.00	25.00	37.60	37.60	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.95	0.72	-3.70	14	116	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	0	65	113	0	94.30	33	72.45	CHANGED	hpPsluYtLFhYRpELsR+pt..chhRlSpoKlhLTcELIupph.p...........sh.tpsSs--Lpt.............LsREl.....a+ccLp................cplc.Rhpchpthuhpp..tctp	...h.PoluYtLFhYRpELpR+ps..phhRlSpoKlpLTcpLIupsh.p..........................sl.ppCSs--Lps..................................LsREl.....FK+cLp..................cplc.Rh+chpphshpp.......................................	0	9	9	36
+5134	PF05307	Bundlin		Bundlin	Moxon SJ	anon	Pfam-B_6974 (release 7.7)	Family	This family consists of several bundlin proteins from E. coli. Bundlin is a type IV pilin protein that is the only known structural component of  enteropathogenic Escherichia coli bundle-forming pili (BFP). BFP play a role in virulence, antigenicity, autoaggregation, and localised adherence  to epithelial cells [1].	21.10	21.10	21.30	21.10	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.14	0.72	-4.12	2	81	2012-10-03 10:38:27	2003-04-07 12:59:11	6	2	47	3	1	100	12	90.00	68	53.31	CHANGED	MVSKIMNKKYEKGLSLIESAMVLALAATVTAGVMFYYQSASDSNKuQNAISEVMSATSAINGLYIGQTSYsGLNSNILLNTSAIPDNhKcstpshlT	..........MVSKIMNKK.YEKGLSLIESAMVLALAATVTAGVMF..YYQ..SASDSNKoQNAISEVMS..ATSAINGLYI...G...QT.S.YoG...LsSs...I...L.L..NT.S.AI.PDNY.KDTpNphl.........................	0	0	0	1
+5135	PF05308	Mito_fiss_reg	DUF729;	Mitochondrial fission regulator	Moxon SJ, Eberhardt R	anon	Pfam-B_6919 (release 7.7)	Family	In eukaryotes, this family of proteins induces mitochondrial fission [1,2].	26.30	26.30	26.30	26.30	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.76	0.70	-5.01	15	225	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	59	0	110	182	1	204.40	35	70.71	CHANGED	hplsl.WpsKPYGSoRSIVR+IGTNLPLtPCPRspFQll..Phsschssssssp...VPShADVuWlAsDEsEoasRlRs-lpspppp.+.sshhshc....RpsSlPsLppcEsphps.....tthss-sAlpKIoALEsELutLRAQIA+IVshQEtpssosush............sss.....o...ssohs.sssp..P....s..........PPPPPPsP.PssuLpsSsSsl............shhpER+p..ppsssscTlspspsKp....phPsML-lLKDMN+VKLR	.................................................................l.WpsKsaGus..RSlVR+IGopLsLh..CsRspFphh..........s.h...sphs.......ppss......VsohADlhWlAt...-.E...tc...s.sRh...R..s..p..h.....hsh.....h.p.hh.hp......Rp....SlPslptpc..p..h..............................thss..Alp+h.ssLpsELutLRuQIApIVshpptps.hsss.................................sssuh..ss.........s...................................ss...sl.pssSs.................................shhtEp+t..pptsts.ps....spspp......hssMhtlLKDhp..phKh..........................................................	0	16	23	52
+5136	PF05309	TraE		TraE protein	Moxon SJ	anon	Pfam-B_7677 (release 7.7)	Family	This family consists of several bacterial sex pilus assembly and synthesis proteins (TraE). Conjugal transfer of plasmids from donor to recipient  cells is a complex process in which a cell-to-cell contact plays a key role. Many genes encoded by self-transmissible plasmids are required for various processes of conjugation, including pilus formation, stabilisation of mating pairs, conjugative DNA metabolism, surface exclusion and regulation of transfer gene expression [1]. The exact function of the TraE protein is unknown.	22.40	22.40	24.30	24.10	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.87	0.71	-5.15	17	480	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	351	0	62	301	17	177.20	31	92.14	CHANGED	M-hphppsptphhhhth.hhsslhslhhhssllh...sathtscpcpsVhs.shstshslSssusDssYLc.hscshhhLpLNhoPcslDh.hpplLphscPuupspl+stLhcpsppl+ssslsstFhhsplcVsPpshpsclpGpL+TalGsptlss....-h+pYphpasacss.ltLssFtpl.ss...-p	.................................................................pt.p.hhh...hhhthl...lsl.l...hsNll..........shpht.s.cpc.s.sl.s.P...sh..s..t..shsVSp.s.sAstsYLpphul.hhtLhLNVoPpsVDtp+psLLphlpPuspsph+...shLtccAc..pIKs.csVsosFh....s.pl.c.s.s.pt.spVplpGh..h+.shl..us.up....s....ph.+.pYhl.hch.p.s.uhhhLtth.p.................................................................	0	17	35	51
+5137	PF05310	Tenui_NS3	Tenuivirus_NS3; 	Tenuivirus movement protein	Moxon SJ	anon	Pfam-B_7740 (release 7.7)	Family	This family of ssRNA negative-strand crop plant tenuivirus proteins appears to combine PV2 [1], NS2 [2], NS3, and PV3 proteins. Plant viruses encode specific proteins known as movement proteins (MPs) to control their spread through plasmodesmata (PD) in walls between cells as well as from leaf to leaf via vascular-dependent transport.  During this movement process, the virally encoded MPs interact with viral genomes for transport from the viral replication sites to the PDs in the walls of infected cells along the cytoskeleton and/or endoplasmic reticulum (ER) network. The virus is then thought to move through the PDs in the form of MP-associated ribonucleoprotein complexes or as virions [2]. The NS3 protein appears to function as an RNA silencing suppressor [3].	25.00	25.00	37.10	37.00	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.45	0.71	-4.39	9	133	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	12	4	0	134	0	172.50	48	84.62	CHANGED	LLhpsshhplll........................phscH..ua.plhptssstEsh.hhlpsuIWlLoap+shssphhhshsshsusasphhlphcPps...spsKCWhCc....hspssL.hhh.s..lpGF.hssE.YhVshK-Hsu........Ehhh.sshKshY+sspKhcHcYllsost.Pl.sppa	..................h..ppshoph.hshcDh....p.....aclhppRhsphccH..pa.pLhptssDt.sht.hltshIWlhuac+shs-chRhsphhhsuohschhhplKPcs...spTpCWhC+....hpp-sLshtl.s..VpGFsssuEhYhVslpDHsG........c.schssh+shY+ssuKh+HKYllsost.Pl.St+a..	0	0	0	0
+5138	PF05311	Baculo_PP31		Baculovirus 33KDa late protein (PP31)	Moxon SJ	anon	Pfam-B_7777 (release 7.7)	Family	Autographa californica nuclear polyhedrosis virus (AcMNPV) pp31 is a  nuclear phosphoprotein that accumulates in the virogenic stroma, which is the viral replication centre in the infected-cell nucleus, binds to DNA, and serves as a late expression factor [1].	25.00	25.00	28.20	27.10	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.01	0.70	-5.13	16	50	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	45	0	0	47	0	275.50	34	95.87	CHANGED	hssshsplhsKh..-susaNKssh-hlpssINhhEKKKIsYplhshPlhsD.............DKKssKRsKKhISNNKYILFNSWY..TK.RpssWPsSasMWNlhKspspspsFVplFDahEKlGKsIss+pusss.................spssssccpssht..hs.s-l.cEsNc+RsKLYsEFYclLspTFpsssAPusS.IYD.................-+LTRshlppulphFKs.lhhcl.......................ppsttstsussshssos.s.t.............RKRKps................htKpstttp+pppppt.ssshtMssDss-DoQ.MSp	.............................................s.ts.tplhsKh..EsSshNKoph-hltshINhhEKKKIsYplhshPshsD.............DK.KssK+sKK..lhoNNKYILFNSaY..TKl+pspWPsSpsMWNlhKspspspsFlcIFDa.h.EKlGKsIps+ppssus.................spssssccppsht.thshs-l.cEss-pRsKLYsEFYplLshTFpsss...A..PusS...IYD.................chLTRshlppuhptFKs.llhch..........................p.s..ssssshssoshstt.p...........RKRKps.................stpp.tttpppptpt..sss.sMssDpspDop.MS....................	0	0	0	0
+5140	PF05313	Pox_P21		Poxvirus P21 membrane protein	Moxon SJ	anon	Pfam-B_7803 (release 7.7)	Family	The P21 membrane protein of vaccinia virus, encoded by the A17L (or A18L) gene, has been reported to localise on the inner of the two membranes of the intracellular mature virus (IMV). It has also been shown that P21 acts as a membrane anchor for the externally located fusion protein P14 (A27L gene) [1]. 	20.70	20.70	20.70	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.38	0.71	-5.03	10	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	42	0	188.40	56	95.28	CHANGED	MSYLSYYNMF-DFsAGAGVpDpELFTcEEEcSFLPKcss..suta....h.......shcs.aP.sILhpNDI+oLlGLILFVLAITTsPlIAlIMIulAShLlPhPSLVIAYCLuhQIh...NsssssslGMSIlCVshSl.lTlhlsSlS...+sshTIoYIILulLFClYAFNlo+hst.pspsss.....tCs+thpuGsKhst-tP	..........MSYLpYYN.MlDDFSAGAGVhD+-LFTEEpQpSFhPKDGGhhps-Y..............ushNca..uIhpNNDVRoLLGLILFVLALhSPPLISllMIhIuShLLPL.sSLVIsYCLshQhh...+sGsuNTlGMSIVCllAAl.IhMAlNshT..sSphhshISYIILhILFhsYVhNIpRpchh+...Shslo.....sCs+sapAGNKhss-hP......................	0	0	0	0
+5141	PF05314	Baculo_ODV-E27		Baculovirus occlusion-derived virus envelope protein EC27	Moxon SJ	anon	Pfam-B_7811 (release 7.7)	Family	This family consists of several baculovirus occlusion-derived virus envelope proteins (EC27 or E27). The ODV-E27 protein has distinct functional characteristics compared to cellular and viral cyclins. Depending on the cdk protein, and perhaps other viral or cellular proteins yet to be described, the kinase-EC27 complex may have either cyclin B- or  D-like activity [1].	25.00	25.00	52.70	52.00	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.87	0.70	-5.34	19	59	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	56	0	0	53	0	272.50	40	97.46	CHANGED	h+s..ptsKl...RTVTEIlsucsKhpK-YDls-hshKN.sSLcSa-phplhLsluKYMAMlssLphoQsLltlF+s+sssccIlolVhsSLuFVHNRhsPhlspFs.cMcFVlscspchuIPGEPIlF.....pps-cpslhChlDRsoIl+hLE+phDsshphpp.sscc.pthKlhcshpsstp+++cs..t.shp.................tsshplsEs-sTQYlTLLlIhEHAYlHYalL+shshhpYhcoLlsHolhspc..sshtsshsNLLLSKF+FslE-.-p.+pssss......hs...lh	..........h.+s...sKl...RTVTEIlsucpKlpKcYDLu-F-hKNLsSLcSa-shcIKLhluKYMAMLssLphTQPLLplFRs+sss+cIsulVhuSLuFVHNRhpPhVspFst+MEFVls-stchsIPGEPIlF......ps-cp......s......llChlDRsSIl+hLp+pFDschplsppspcp.pth+lhKshssstp++pppp...t.....................sshplsEs-sTQYlTLLlIhEHAYlHYaIhKNashhpYscSLlDHolFssK.+sshssphsNLLLSKF+FslE-.-p.pppsss...thh...........................	0	0	0	0
+5142	PF05315	ICEA		ICEA Protein	Moxon SJ	anon	Pfam-B_2792 (release 7.7)	Family	This family consists of several ICEA proteins from Helicobacter pylori. Helicobacter pylori infection causes gastritis and peptic ulcer disease, and is classified as a definite carcinogen of gastric cancer. ICEA1 is  speculated to be associated with peptic ulcer disease [1].	19.00	19.00	21.10	20.70	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.65	0.70	-5.05	2	70	2012-10-05 18:28:12	2003-04-07 12:59:11	6	1	40	0	4	69	19	165.40	58	93.91	CHANGED	MphoKpELFLcLApPscpGlSRWVps.EFhGcYpsLpLGNGGSWCRpsSsLA+-ahlEFDKt.TsGNSIDtIRLNGaNpcphFpQ.I+pDIKshhpppsCsMhGVpGpSENTpIEIDHKDGRKsshRVSDlpTQph-DFQsLCKAsNDhKRQICKpCKEoshRasAppIsGNPYsFY.G-.pYs...GCVGCYQYDPlpYRKosscRIhsEuhphs...haphhYppcss	.......................................................hpRWlts.EF.sthptLt.hu....Nst.....sWhRtsSshA+ca.lEFDKtp.o.GNSID+IRLNGapscpsF..NQsIRpDIKsaYpppsCsMpGspGpSENTpIElDHK..DGRKsD.RVS....D..hss.Qph.-DFQsLCKAsNDpKRQICKcCKEoGhRasAppI...GN....YsFY-G.........t.pYD..............GCVGCYQYDPlpYRKpsscRIhpEuhphs..................................................	3	2	4	4
+5143	PF05316	VAR1	Yeast_VAR1; 	Mitochondrial ribosomal protein (VAR1)	Moxon SJ	anon	Pfam-B_7802 (release 7.7)	Family	This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal  proteins are encoded in the nucleus [1]. VAR1 along with 15S rRNA are  necessary for the formation of mature 37S subunits [2].	22.10	22.10	22.40	22.40	20.50	22.00	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.70	0.70	-5.85	5	28	2009-09-11 14:04:11	2003-04-07 12:59:11	7	3	26	0	9	39	0	290.00	34	79.83	CHANGED	pKhLLKNhLLKMNsNp.MN.shchsp+Ns.h.sKYlpEhNNKGNKLQ+lNNMNNWssQlYNYNKNNsINshlsDKLlNKLLYKLMslK..hINNN....sst..p+IIIsKPhaKHolNKlNI+FYY....YNsNhpshNNNNNpYYhNMINKLMNILN.....NpN.hNMN.NluNILShYYNKKVhIEsIKLpYlYNNN-IhNKYISlhDh-KYNNGLssc.Yp+lLNNhMPKhNspNIpMNYINNINNhNNlKY.NNMI..L......sSNN.l.........NIpNIYNshsINpIsM-LLMaKYLIGWSILaKGRLNKN..lSRosKspLLNGShsNKhYhKs...........................NINpNYKLNYIPNNHNIhNhNNVN..KNGKYNIKVKLNaI	......................................hK.hLh.hp.p..hp........p.............................s..sspL......QplNphNsap..hYpaNps..l..hh.sphhppLLhKhh..hh.....ss.............pIlhS+.shhpHshN+.lsI+FYY.......hp..s....p...s...Np.spYYhshhscl..hNhhs........Np..s.........ssLsNlLShYY.N.KcVpIpPI+LpY.YhNo-IhophI...h.shsp.h.s.psl.hp.a.+hLpshhPhhNsp......It....hsYlss..hs.s......hN...p.ph.NNhh........ssN........................slpNl.Y...pshslpp..hs....shLhhKYLsGholhhKG+h...pp..hsRo.p.h.lhpGoFpNhhh.hs...........................p.h.p.spYKLNYhssNhsh.s.s....p..lN..Ks...GKasIKlKLNhI...........................	0	2	6	8
+5144	PF05317	Thermopsin		Thermopsin	Moxon SJ	anon	Pfam-B_7819 (release 7.7)	Family	This family consists of several thermopsin proteins from archaebacteria. Thermopsin is a thermostable acid protease which is capable of hydrolysing the following bonds: Leu-Val, Leu-Tyr, Phe-Phe, Phe-Tyr, and Tyr-Thr. The specificity of thermopsin is therefore similar to that of pepsin, that is, it prefers large hydrophobic residues at both sides of the scissile bond [1].	25.00	25.00	52.70	36.10	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.80	0.70	-5.47	25	105	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	33	0	57	105	6	261.40	30	40.72	CHANGED	hhhpsh.ls..hhhhhstss........PhGlusYul.........shslpTspVlGhhNIsSLp..uastsstt.......shuASLQLNslLp.sshhs.tshtaWlQNVl.......hF.Tsssp...hsalDNlWNhTu.shusloss.l....pGpGtl..........p.YYsYus......shshshPhohhLhlNsohsst.ushltFGYsl.psusl........YDsVslsss.....s.tsA.hhlsGhshss.............tGl.hhDsELVaGGsGsGpsssapshsupLuLaY.hsu..ssapshsssYsaGhDTuEoutslp	.......................................................................................h.hs..........h.h.s.ss........PsGlssYGl............hslpTspVlGhlsIsslp....uh.shosst......sshuASLQLNshLp.hph.s.tphtaWlQNVl........F.ssssp...hphh-NlWNhTu.s.huslsss.l....pGpGhl.........ttt.YYsYss.........shhphshPhohhLhlss.ohs.st.sshlsFGYsh.psush......................hYDsVsl.ss........h.su.hhlsGh..s..hss.............hGh.hhDsELVhGGsGsG.p.sshhpph.suhLuLhY.h...ps....sshsshsshYsaG..hDTuEoussl.h.................	0	11	25	50
+5145	PF05318	Tombus_movement		Tombusvirus movement protein	Moxon SJ	anon	Pfam-B_4393 (release 7.7)	Family	This family consists of several Tombusvirus movement proteins. These proteins allow the virus to move from cell-to-cell and allow host-specific systemic spread [1]. 	21.30	21.30	21.50	21.40	18.30	21.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.69	0.72	-3.35	6	85	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	24	0	0	86	0	64.50	39	91.02	CHANGED	MDsp....ps.p.l.....tsGcpctuGp+GppK..s+RpVApcAl+....K..pussuosGGsWVhVADKlEVoIsFNF	......................s.p.........pV.......shstppthsus+GKpK....s++sVA+DAls....K..su.p.cussGusaVsVADK..IcV..sIpFNF........	0	0	0	0
+5147	PF05320	Pox_RNA_Pol_19		Poxvirus DNA-directed RNA polymerase 19 kDa subunit	Moxon SJ	anon	Pfam-B_6945 (release 7.7)	Family	This family contains several DNA-directed RNA polymerase 19 kDa polypeptides. The Poxvirus DNA-directed RNA polymerase (EC: 2.7.7.6)  catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.	25.00	25.00	211.80	211.60	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.95	0.71	-4.50	12	52	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	36	0	165.80	63	95.59	CHANGED	M--SsDI..sa.S---p..pY-E----...p.tEuhsooDlsshKpSsh+h.puhSpsh--t....pss.+plos+IpsIK+RYTRRISLFElTGIlAESYNLLQRGRLPLls-LSD-Th.+pslL+lllcEIEEGsCPIVIEKNGELLSlsDFDpcGLpaHLDYIhsIWKpQpRh	....MADoDDII.DY...-SDD.s..EYE---E-..-E-uESLETSDlss..pSuYKI.ESASopIEDA....poshK+lus+ISALK+RYTRRISLFEIsGIIAESYNLLQRGRLPLVS-hSDETh.KQNhLHVlIpEIEEGoCPIVIEKNGELLSVsDFDK-GLKaHLDYIIcIWKhQpRY	0	0	0	0
+5148	PF05321	HHA		Haemolysin expression modulating protein	Moxon SJ	anon	Pfam-B_7025 (release 7.7)	Family	This family consists of haemolysin expression modulating protein (HHA) homologues. YmoA and Hha are highly similar bacterial proteins  downregulating gene expression in Yersinia enterocolitica and Escherichia  coli, respectively.	25.00	25.00	25.60	25.50	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.76	0.72	-3.83	14	1466	2009-09-11 00:35:18	2003-04-07 12:59:11	6	1	560	3	79	307	5	56.20	58	82.15	CHANGED	hphR+Cooh-TLEKlh-+p+.p..Lsss.EhpsFpuAADHRLAELsM.sKLYD..KlPssVWp	......h+hR+hpol-oLE+lh-+s+Yp..LoDs.....ELtsFYSAADHRhAELsh.sKLYD..+lPpSVW+............	0	4	16	48
+5149	PF05322	NinE	NINE; 	NINE Protein	Moxon SJ	anon	Pfam-B_7029 (release 7.7)	Family	This family consists of NINE proteins from several bacteriophages and from E. coli.	25.00	25.00	30.30	30.20	23.80	23.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.15	0.72	-4.23	3	157	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	136	0	0	53	0	58.20	92	95.15	CHANGED	MRRQRRSITDIICENCKYLPTKRSRNKhKPIPpESpVKTFsYluuLhDS+Ws...RaCs..R+TR	.......MtRQRRSITDIICENCKYLPTKRSRNKRKPIPKESDVKTFNYTAHLWDIRWL...RHRA..RK........	0	0	0	0
+5150	PF05323	Pox_A21		Poxvirus A21 Protein	Moxon SJ	anon	Pfam-B_7034 (release 7.7)	Family	This family consists of several poxvirus A21 proteins.	25.00	25.00	29.10	28.90	18.50	17.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.51	0.72	-3.67	11	60	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	46	0	0	41	0	112.80	61	97.71	CHANGED	MIoLFLlLCYFILIFNIIVPsIuEKLRpEacAas+Y+pl.ppcalCVDspLhsYsFssoGlpAphhlDsss.sPLPCS+hspscst..chlsC-..stsslhch+csCu+AYh-LFh	MITLFLILCYFILIFNIIVPAISEKMRRE+AAYlsYK+L.sKsFICVDDRLFSYsFTTSGIKAKhAVDscs.lPIPCS+IN-VNsN...csLhCD..pDcsDIs.sFsRSChRAYuDLFF.	0	0	0	0
+5151	PF05324	Sperm_Ag_HE2		Sperm antigen HE2	Moxon SJ	anon	Pfam-B_7044 (release 7.7)	Family	This family consists of several variants of the human and chimpanzee sperm  antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a  family of androgen-dependent, epididymis-specific secretory proteins.The  EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages.  The translated putative protein variants differ significantly from each other. Some of these putative proteins have  similarity to beta-defensins, a family of antimicrobial peptides [1].	20.10	20.10	20.80	22.90	18.20	18.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.28	0.72	-4.06	4	65	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	19	0	13	61	0	68.50	59	59.33	CHANGED	KphLhP.hsSLLLVALLFPG.SpApplNHpsTEuPRc.pEEusGQGsNcSpLLHHpVKRh.llPRpPPY.Es-P	..............+QRLLP.hsSLLLVALLFP.G.SpARHVNHSuTEu.pEL...REtAsGQGTNtSQLL+HsVKRt.l.PRTP.Y.t................	0	2	2	2
+5152	PF05325	DUF730		Protein of unknown function (DUF730)	Moxon SJ	anon	Pfam-B_7197 (release 7.7)	Family	This family consists of several uncharacterised Arabidopsis thaliana proteins of unknown function.	27.20	27.20	27.60	172.60	26.70	27.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.63	0.71	-4.31	3	10	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1	0	0	10	0	117.10	82	83.76	CHANGED	MEIRMRMRYGENRRRDKGVPIECDCNAKVVVATS+DPVTSGKLYFSCPYEISDGPGRGCGFKRWWTVALCDEFDMIKEEpsEMKKDLEAANK+VEuQsEKIFLMEKKFETLEKKYESlNKYS	.MEIRMRTRYGENRRRDKGVPIECDCNAKVVVATSLDPVTTGKLFFSCPYEISDGPGpGCGFKRWWTVALCDEFDMIKEEToEMKKDLEAANKRVESQsEKIFLMEKKFETLEKKYESLNKYL......	0	0	0	0
+5153	PF05326	SVA		Seminal vesicle autoantigen (SVA)	Moxon SJ	anon	Pfam-B_7065 (release 7.7)	Family	This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory glycoprotein suppresses the motility of spermatozoa by interacting with phospholipid. PIP, has several known functions. In saliva, this protein plays a role in host defence by binding to microorganisms such as Streptococcus. PIP is an aspartyl proteinase and it acts as a factor capable of suppressing T-cell apoptosis through its interaction with CD4 [1].	23.10	23.10	23.10	23.20	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.71	0.71	-4.34	11	63	2012-10-03 02:52:13	2003-04-07 12:59:11	6	1	32	1	27	173	0	111.50	44	84.82	CHANGED	sLQhLapsossThLLlLCLpLtss....cuQ-N..pppslhhshclssss....spspEsTVpLsVpTpl+ECMVlKsYLhSNhslc.GuFNYpaTuCLCsp.PpsFaWDlhsscTsplsssVDll+EhsICPDD	......................thhhpsssshhhLllhL.Lths....puQ-s..sR+hlhhshplPpos....cts-ElTssLpVpT-L+ECMV.lKsY..L..h..S..s..h..s..l.-...GuF.N.Y...p..YT.uCLCs.s.P+TFYWDhh..ssc..T....spIsuVlD..llpEhsICP-D.......................	0	1	1	6
+5154	PF05327	RRN3		RNA polymerase I specific transcription initiation factor RRN3	Moxon SJ	anon	Pfam-B_7041 (release 7.7)	Family	This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required  for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae [1].	20.60	20.60	23.90	21.60	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	564	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.94	0.70	-6.40	33	404	2009-01-15 18:05:59	2003-04-07 12:59:11	6	12	278	2	283	410	5	426.80	23	78.29	CHANGED	sstpsschotphhcp.....hV+cALpphp................pG...-sstacplpphh..........tshptt...-s.s.sphpplLpsLtssVstLDps.sssLVp.ulLsh.pWh.s+spsh.........lctYlpFLssL.............suup.spalstllshLlspFs..spt...ssp.........t....p..phhpphHthLppllchlPsusshL.shLsppFPat.scopcshhs.YlpNLL+ltpYs...spLptclhpLlh-+llclDV..........phps-h--l........-D-ppcth.tt.t.pstppth.-.-sss...............ttp.....s.ps-sp.....................................spphpsl+phsp+LDsllshlhsahcs............shsssphsp...............................s.slFcsLlshFpshILPTapo+asQFLlFahsphpsphs-.pFlspLhclsh........s.sspss.h..R.uAssYLuSalARA+alstpplphlhshLssaLspYltpp-sss...............tssshcc.atsFYussQAlhYlFCFRa+sLh.........................sps.........hsahsslcph.Lp+slhSKLNPLKhCsPsVVstFA+lup+hsl..sYsaoI..lEpNpR...................t+lsphhuts..................t....p.........L-uaFPFDPahL.pS+ch..lcs.YlpW..ptlsspp	...................................................................................................................t....................h..hh.t........................p.........ht.hh..h.................................t.......h..hl..h.t.h..lp....t...ht.l...lp..lhph..W....th.s..th...........hp..aht..hlh.L.................sss..s.aht.shthlhpthh............................................................t.hH..hlp.lh.phhP.s...hl.sh...l....ptaPhh.....ppstt......h....Yhp.Nlltl..hh...stlt..tlhthl...hp+hlplDl......................pht.hpph..........-ct...t.................................t.....p..pt.t..................................................................................................................t..t.hp.hhpplD.hh.hhhphhp...............h...p...t.................................................................................................................................................hap.LhthFpphlLss.atopasQa..lhFahsph.p.................t...............hhc...tFhthLhp.hh..........................................s...sp...ss.h.....R.sussYluSalARuthls...hl...............h.hhphLhpah...pt..a.htp.ptts................................................................ssht.h..at.FYushQAlhYhhsFRhcplh.....................................................................pt............hth..pl.p......hpphlh..s..p..lNP..L+hC..slst.F...utlspthth....ha.hhsl..lEps.pp..........................................l..hhs.......................................................................L-saFPFDPh.L..st.p.h..lt..a..ap...................................................................................................	0	116	178	239
+5155	PF05328	CybS		CybS	Moxon SJ	anon	Pfam-B_7102 (release 7.7)	Family	This family consists of several eukaryotic succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) proteins. SDHD encodes the small subunit (cybS) of cytochrome b in succinate-ubiquinone oxidoreductase (mitochondrial complex II).  Mitochondrial complex II is involved in the Krebs cycle and in the aerobic electron transport chain. It contains four proteins. The catalytic core consists of a flavoprotein and an iron-sulfur protein; these proteins are anchored to the mitochondrial inner membrane by the large subunit of cytochrome b (cybL) and cybS, which together comprise the heme-protein cytochrome b. Mutations in the SDHD gene can lead to hereditary paraganglioma, characterised by the development of benign, vascularised tumours in the head and neck [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.54	0.71	-4.54	48	384	2012-10-03 07:11:12	2003-04-07 12:59:11	7	5	272	30	229	486	257	123.80	29	70.69	CHANGED	hsphphlPp....Pthl.GolN..-sh...PtssthcGShHWshERlluluLlPLssssahs.ss.........sslhDusLussllhHsHhGFpusIhDYlsp+haG.thtphAhhlLthuoslshhGlY.hEop-s.GlscslpplWp	...................................................................h...........................t.......st..ssttpuShHWshERllusuL...lP..Lhs...s..sahs..............................sss...hDshL...u...s....s.L...l....l...HsHh...Ghp.uslhDYl.....phhs...thp....phu.h.h.hL.h.h.h.o.sh.shhGla.hpp......p-s.GlscslpplWp.......................................	2	70	121	188
+5158	PF05331	DUF742		Protein of unknown function (DUF742)	Moxon SJ	anon	Pfam-B_3675 (release 7.7)	Family	This family consists of several uncharacterised Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.37	0.71	-4.48	14	710	2012-10-04 14:01:12	2003-04-07 12:59:11	6	6	167	0	269	736	6	113.50	37	80.96	CHANGED	scssshVRPYslTsGRocsst...slsLholVsAtsstP.................sshtPEctpILcLCps...shoVAElAAtLcLPluVV+lLLuDLh-sGtlss+tPhs......sphPDpsLLccVlsGLRpL	....................................................................................................................s..tsshVRPYslTu.GR...Tcssh.........sLsL.sl.Vssp.s.s.ss.....t..t..........................................hsht.sE..+ppIl.p..LCpp....shS...VAEluApLcLPlGVsRVLluD.LsssGhlpl.+p.ssss..............s.....t..........ts..D.....h..sLLccVLsGLRpL..............................	0	76	213	260
+5159	PF05332	DUF743		Protein of unknown function (DUF743)	Moxon SJ	anon	Pfam-B_4046 (release 7.7)	Family	This family consists of several uncharacterised Calicivirus proteins of unknown function.	27.70	27.70	27.70	120.10	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.30	0.72	-4.09	4	42	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	18	0	0	36	0	104.60	56	96.36	CHANGED	NhGLsLlsolANAhhEGp+l-LsupuLuhpp+hh-sEpcaNhsRLsF-...........KppFppsh-L+lpGslhRhpthRAAGaRlNPYSNGpQlahDEsttApLpSYhsFYKs	.NSILGLIDTVTNTIGKAQQIELDKsALGQQR-LALpRhsLDRQALsNQ...........VEQFNKlLEQRVpGPlQSVRLARAAGFRVDPYS.sNQ.aaD-thsA.hhSY+shaKs.	0	0	0	0
+5161	PF05334	DUF719		Protein of unknown function (DUF719)	Moxon SJ	anon	Pfam-B_7667 (release 7.7)	Family	This family consists of several eukaryotic proteins of unknown function.	20.80	20.80	20.90	22.30	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.36	0.71	-4.25	6	168	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	81	0	95	154	0	158.60	48	33.17	CHANGED	S..puu.WG....hWGuhupSlLSoAotslATl...hTpVppthpsslGlPsPpELutpsstEcAEpstpssspt-s......-sspGots.....hssuFG.hstlsssVpshGppVloGGLDsLEhIGKKTMslLtEsDPGhhpp+pLh....N+sssLSQVLREAKc+.EchpcshpQlphEppKt..hHathLFD-YpGL	.......................................su..Wu....hWG..oW.G.K.S.lLSoAoATVups..............los.VhEK...A....t..soLtI.ss....sph.up.pst...ts.cp....t.............................................ptspssss............su.u.sh...G.hh.......Ssl.o..ssV...........Q.sT..GK....oV.loGGLDALEFIGKK..TMsVlAEuDPGFK+TKsLM............pRssoLSQlLREAKEK.Ec.pphup...plshEps......sHYGhLFDEaQGL.................	0	23	29	56
+5162	PF05335	DUF745		Protein of unknown function (DUF745)	Moxon SJ	anon	Pfam-B_5169 (release 7.7)	Family	This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.	22.40	22.40	22.40	22.60	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.37	0.71	-4.77	14	190	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	39	0	120	201	4	174.00	35	58.26	CHANGED	sshs...htsss+pKuSsIApKAAp-AKsAsDuQsuAuctAupplKppLA-KAhtAA+AAEAALAGKQQll-QLEpElpEActVVpE.ppuLpsopssApuAttssppAppplpsLpshlcsApsslssh-psAssAQpElsEKsQLL-AA+pRV-hLt+QlpsA+tDa-pTKpAAhKAACAApEA+Q+A	.........tttt.......hpspptussIAppAAppAKuAsssQ.uAuptAA.psKtpLAp+.AhpAApAApA.sLsGKptllcpLcpchpEActsVpcEpspLppu.pssspuAtp.......ssppAppp....lpsLpshlpsApsshsssppsAssApp-Lup.....+sphlts.A+pRl-tLpcQltsA+tDappT+pAAhKAssAA.EAppps.............................	0	34	39	84
+5163	PF05336	DUF718		Domain of unknown function (DUF718)	Moxon SJ	anon	Pfam-B_7227 (release 7.7)	Domain	This family consists of several uncharacterised bacterial proteins of unknown function.	23.40	23.40	23.70	23.40	22.70	23.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.32	0.72	-4.23	61	1431	2012-10-02 00:20:33	2003-04-07 12:59:11	8	7	1252	8	330	844	242	104.20	38	92.26	CHANGED	pRhuahhpLc..Psph-EYc+pHsp..l...WPEllptL+psGlpsYSIaLc.tppshLFuhhEhps.....-tshs...thupsslsp+WWshMuslhc..s.ssspPsp..........ssLpcVF+Lc	.........................RhAalhplp..P-..t..hcEYp+RHst.....l....WPEl...ps...s...L..+p..p.GspsYuIaLc..pp..........p.....s.....hLFuhlEhcs................Et.c..h..s.....tl.A..so....s....lsQ+WWcaMs....clh....ssP.D..s.......o....Pss.................spLpEVFaL.............................	0	100	218	277
+5164	PF05337	CSF-1		Macrophage colony stimulating factor-1 (CSF-1)	Moxon SJ	anon	Pfam-B_7649 (release 7.7)	Family	Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth  factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic  lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility [1] and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption [2].	25.00	25.00	35.40	43.70	24.20	23.60	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.66	0.70	-5.06	9	118	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	29	2	35	134	0	226.10	38	95.29	CHANGED	hTstGuut.sPSsshh..Gsc.lLssLLsoNhlsEEsStcsS............ahlGsGplps.pph.cuphpsSstlshphhDQc.lD.....lpcAaLhs.s.McsThchpsNTPpts..........chsSshscDapE.spAplpTh+.p........................PLt.LEthKs.........................shp-p+sLhEh-hs.hScssspshA+hsShs.........LhspGpspQc.uSssPQhPt.VFhlLsPSlILVLLsVGGLLFYph+hRSHpDPQtsDSSstpPEsSsL.TQD.DRQhELPV	......................................t.tPsssh...G...lLsshLsop..hhEEsStpsS............ph.GsGplQs..p.th.ss.hpsSs.lshphhsQp.hc.....lppshL.h.s.hcsThphpspTPptp............chtSs..hh+DhpE.spsplpohh.p........................PLt.LEth+.shp-p+s.h....-h-hs.........hScsssp......shAchsS.s.........Lhspup.ppc.uSssPp.s......LsPS....hhsluGLha............p-spts-us...Pp.t.p.PL.T...D.s..pthphPs..........................................................	0	2	2	7
+5165	PF05338	DUF717		Protein of unknown function (DUF717)	Moxon SJ	anon	Pfam-B_7144 (release 7.7)	Family	This family consists of several herpesvirus proteins of unknown function.	21.30	21.30	26.00	65.80	21.10	20.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.65	0.72	-4.02	11	20	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	18	0	0	18	0	56.00	39	70.93	CHANGED	sploEpDFppChpFFs+Pl.pllspsupuLsslchscossQpl-pLsLlLDLlGTE	.sploEpDFp-CtpFFs+PLpcllsssucuLsslclscSssQplEpLsLLLDLlGTE	0	0	0	0
+5166	PF05339	DUF739		Protein of unknown function (DUF739)	Moxon SJ	anon	Pfam-B_7696 (release 7.7)	Family	This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.	19.50	14.00	19.60	14.40	19.20	13.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.91	0.71	-4.37	11	78	2012-10-04 14:01:12	2003-04-07 12:59:11	6	1	77	2	9	39	3	67.70	43	73.40	CHANGED	hsaD..........YScLpG+I...............lE+YGo..............................pasFApAls..lSE+olS.hKLNsKl..................................sWpss-ItKAh-.lLulsp-.............clspYFFph	...............................hsh..............atpLtG.l...............lEKYGo....................................pYsFAhAht...LSERolS.LKLNsKl...................................W..s...tshp.hlth..p......................h..................................	2	4	9	9
+5167	PF05340	DUF740		Protein of unknown function (DUF740)	Moxon SJ	anon	Pfam-B_7873 (release 7.7)	Family	This family consists of several uncharacterised plant proteins of unknown function.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	603	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.33	0.70	-6.15	6	176	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	19	0	119	155	0	210.00	18	72.48	CHANGED	ssspssp.+RhSTSCcRHP-E+.FTGFCsSCLpERLSsL-ts.......SSSuptPso.Sssul+ulFt.s.sss..............u.hPELRRsKSFSs.+...........ssAusSsu.EPQRRSCDVRs.+soLhsLF.pDD-cplsSs......sss..p.....RcshVs-.lhEE-pEh..EcD--...t................Estcll-Epspc.................hp-EEtKsMKDa.hDL-Spp.+K.ssKc....utSFasAASVFSKKLQKW+pKQKhKKcc..sGsuuutss.....................u-huhGRRSCDTDP..............RFSlDuGRlShDDstaSFDEPRASWDGpLIG+oh......sP.....hPoMhSVlEDuP......lpRuDhph......Psss.lp.pcu-pD..h..PGGSsQTRDYYhD.sSSRRR+SLDR.SsShR+hu...ltElDElKsluNucsSs...........hsppppLRDpsh.s.sNhcsEotE.su.............p.sust.cKKs+RWuK.WsIaGLIaRKsss+.......cp-p.p+hs.ushVERSLSESW.s-LRsst......GsuPKMlR.........sNSslShRS..SG.pGG.............................G.puppp.phlpp+sKsupYSs.cssENGMLRFYLTPh+uptpuuGu	..................................................t..............C.hHP.p..hsGhCs.CLp-RL..lt.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s.........................................................................................	0	11	65	90
+5168	PF05341	DUF708		Protein of unknown function (DUF708)	Moxon SJ	anon	Pfam-B_7259 (release 7.7)	Family	This family consists of several uncharacterised nucleopolyhedrovirus proteins of unknown function.	21.30	21.30	21.50	41.70	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.33	0.72	-4.25	24	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	55	0	0	53	0	105.70	44	78.30	CHANGED	phpWpllss......shlEVsPc-REpAWKDLll.sLpsoPp..oaRTtlp+AshEpFDYKpPIhY-lKp+pLhlss-plhpALs..hPp.sshsshslsshplhhs....FIhslLl	...lRWp..lLNs......DclEVsPEcREpAW+-LlIsllpsoPt..TaRThlpKAshENFDYppPIlYslKsKpLllss...EplppALN..RPt.tshsshNlsshplhLs..FIhslLL.....	0	0	0	0
+5169	PF05342	Peptidase_M26_N	Peptidase_M26; 	M26 IgA1-specific Metallo-endopeptidase N-terminal region	Studholme DJ	anon	Merops	Family	These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with Pfam:PF00746, they may be attached to the cell wall.	25.10	25.10	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.59	0.70	-5.40	19	698	2009-01-15 18:05:59	2003-04-07 12:59:11	9	66	278	0	17	423	8	240.30	39	13.51	CHANGED	-pl-hhp-YThsTp......shs.s-sspsct.p-p.......hp.s.KKlEL+NlsslcLhp..-NGp.ppps.LsphPs..ssssYalKVpSss.K-shLPVsSIEEssc-GpslYKlTApsscLlQ.ct-sphp-sasaYltKttsc-sslYhsFpsLVcAMppN.sGTa+LGAsLsAspVphssss+SYlpGpFoGpLlGsp-GKcYAIaNLc+PLFssl.puuolcclsLKsVNIstp.....sclAolAppspsuopIcNV+VsG	.......................................plchhptYplpTph.....sasp..upus...c.o.pt.c-.p...........hplshKKl..El+..NIssspLhp.........-sGp.p..phshL...sphPs..sspphalKVpSps.KsshLsVsS.IEEssh-GpplYKlsApApcLlQ..ctssph.pppYsaYlp.K..t.sc.-ssVYhsFppLVcAMpssPsGTF+LGAslsAspV..ssss+S..Y..lpspFpGpLh.o.s-G.KpYuIaNL...c.......+P.......LFssl.pu......uTVcslsLcsVsIsh...........-slAs.lApphpssopIcNV+VsG.............................................	0	2	4	8
+5170	PF05343	Peptidase_M42		M42 glutamyl aminopeptidase	Studholme DJ	anon	Merops	Family	These peptidases are found in Archaea and Bacteria. The example in Lactococcus lactis, PepA, aids growth on milk [1].     Pyrococcus horikoshii contain a thermostable de-blocking  aminopeptidase member of this family used commercially for N-terminal protein sequencing [2].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.74	0.70	-5.64	69	4278	2012-10-02 19:46:12	2003-04-07 12:59:11	9	6	2184	65	699	4495	777	284.40	30	81.45	CHANGED	Gsllup.ppG...su..+lhluAHMDElGhMVppIccsGhL+hsslGGhsspsl.up+lplhscpG...l.GVlGstsP..Hlhc.stccppshp....hc-lhIDlGsps+--AcchGlplG-hlsh...cschthlssph.lhu+AhDsRhGsslll-ll+pLpcpph...sslahsuoVQEEVGLRGApsustplpP-hslAlDsssu.uDsssssctp.....lGpGsslphhDss.....hlhc.plpchLh-hAccpsIPhQhc.hhssGGTDAuuhphs.ttGlPouslulssRYhHS.sEhhchcDlpsshcL	.....................................................................................................................................................Gulhsp..h....pu....tpsu....+lhlsAHhDElGaMVppI....c....c.s....G..hlchps..l...G..G.....a.spsh.upplplpTcp....G....plsG.ll..u..s..hss.........Hhh.........p..s.........t.........tc.........p...p........p.....hp..-lhlDl...Gs..............p...o...c.-.E...s.c.p.h.GIcsG..D.h.....ls.........csp.h...t.h........h...s...sst...lhuK.A.....h.Ds.RhGss.hllclL..c.p.L.p..s..p..p..ls...........hsla.hs.soVpEE...V.G....l............RG....A....p........s....u......s....p....p.......................l......p.P...D......l...................h....l.u...l......Dsuss....sD...s......s......ss.php........hG.pGshl.t.h.h..Dss..........hlhp.p.l..p.c.a.l.h.s.l.A.....c.....c..p.....sIPa.........Q...h.........p....h....h............s...t...........G...G..TD.A...u...u....h...p.h.s...s..sGlP...s...s.slGl...ss..RYhHo....hphhchcDhtsshpL....................................................................................................	0	268	469	596
+5171	PF05344	DUF746		Domain of Unknown Function (DUF746)	Yeats C, Eberhardt R	anon	Yeats C	Family	This is a short conserved region found in some transposons. Structural modelling suggests this domain may bind nucleic acids [1].	23.70	23.70	23.80	31.10	23.00	23.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.76	0.72	-4.44	10	78	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	34	0	16	77	0	63.60	41	34.53	CHANGED	c+hcthIRhLSpPlSlh-AA-tlGsscssltchVchFRpalLpLDPSGpaEsRlRLGsRPspsss	......c+hcLFlphLS.PlSshpAuctlGot.ssltchlphaRpalLpLDPSGphEtRlRLGs+ssphss......	0	4	8	12
+5172	PF05345	He_PIG		Putative Ig domain	Yeats C	anon	Yeats C	Family	This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to  (Pfam:PF02494) and (Pfam:PF00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (Pfam:PF02639) and  (Pfam:PF02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei ([1]).	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.37	0.72	-3.94	108	2176	2012-10-03 16:25:20	2003-04-07 12:59:11	7	369	532	0	988	2359	2162	49.40	32	9.08	CHANGED	oaoh....................ssssLPsGLol...........sssoGsloGT....ssss...............G.sashslssossss	...................................................sh.....................ssuLP..sGLoh...........................ssu....TGslSGT.........Poss....................................G.sa.s.lsVosTDss......................................................	0	490	754	893
+5173	PF05346	DUF747		Eukaryotic membrane protein family	Wood V, Bateman A, Murphy T, Mistry J	anon	Pfam-B_13582 (release 7.8)	Family	This family is a family of eukaryotic membrane proteins.  It was previously annotated as including a putative receptor for human cytomegalovirus gH [1] but this has has since been disputed [2]. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.	25.00	25.00	27.70	25.10	24.10	23.60	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.26	0.70	-5.39	36	347	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	271	0	241	343	1	312.30	35	47.39	CHANGED	p.....ptlsttphsDllphhlllhsshlLp..........hl.DsS+hYHhIRuQusIKLYllaNlLElsD+LhsShGpDll-sLhpssh.........................................................................................................................................................................................................ttpthhchhshahlulhYlshHuhlLlhQsloLNVAlNSasNuLLoLLlSNpFsElKuoVF......KKF-+EsLFQlotuDllERFpLhlhLhll..ulRNhhph....................................h.tuap.....................tlhushlhVluSElh.VDWlKHuaIsKFNcl+splYpcahplLs.....tDhh............................t.hsts.hls....+RlGhsshshsslhl+hhh.hhphhh....................................................................................................hthlshhhlhlhsahhLlhhKllLuhhllpaupphhp.phc	...................................................................htstphsDllp.hhl.llhsh.hhh...........hl.DhSh.hYHhIR..uQ.usIKLYllaNhLEluD+LhuuhGQDll-sLa.ptt.............................................................................................................................................................................................................................................................................................................................................................................................ptp...p...thht.h..hhhh..ul....hY...s....hhHuh....hlhhQsh......oLNVAhN..Sa.s.............puLLTlhhSNpFsEIKu...........oVFKKF-KpNL...............F.Qlo.s....uDlhERFplhlhLhll..shRNh.ph.....................................................p.ah........................lhsshhhVlsoEhhVDhl.............KHAaIsKFNpI.p.sslYpcaht.Ls.........hDhh..............................................................s....sthsptls....RRhGh.slPlusLhlRsh.hpshp.............................................................................................................hhh.hhhhhhhah..hLlhhKll.uhhLlthupph.t.............................................................................................	0	83	142	206
+5174	PF05347	Complex1_LYR		Complex 1 protein (LYR family)	Wood V, Bateman A	anon	Pfam-B_15215 (release 7.8)	Family	Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex.  In Saccharomyces cerevisiae, the Isd11 protein (Swiss:Q6Q560) has been shown to play a role in Fe/S cluster biogenesis in mitochondria [1][2]. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.93	0.72	-4.17	246	1703	2012-10-01 20:54:40	2003-04-07 12:59:11	10	21	313	0	1190	2012	12	60.50	22	42.65	CHANGED	pp..lLpLYRplLR..pu.pp......hsshs..........+phh...ppplRspF+c..s+s...hp.-.ppl.....pth......lppupcpLph	...................pllpLYRphLR......ts..pp........................hst.ts............pphh.........ppt...lR..ppFcp....s+s......hs..-sppI..................pth..........................lppup..h.....................................................	0	377	651	958
+5175	PF05348	UMP1		Proteasome maturation factor UMP1	Wood V, Bateman A	anon	Pfam-B_18845 (release 7.8)	Family	UMP1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. UMP1 is required for the correct assembly and enzymatic activation of the proteasome. UMP1 seems to be degraded by the proteasome upon its formation	21.50	21.50	22.20	21.50	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.42	0.71	-4.19	7	345	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	278	0	233	323	2	122.10	29	80.51	CHANGED	shpshthtlsuhht.hcshphGhhsshsplhssHPLcss.cN.hptpQcphphphlRph.GlthPLKhsMEpplhpphpR.P.hlsSuphth-lLsGp.-slsFEDhhNsPppuEhhh...p.HthhEhpLGl	..........................................................................s................c......t....G...........s..ht....s.p..l.h....s..s..HPLEtp.ps.aptspcphphptlRplaGhttPl+htMEhc.llp.......p........sp.+.hP..............h.L...s.....S.......S..........s..l..thDlLp..Gp--slsaED.....lh.....s..ss.p..tp..-...ht............p.Ht.hEh+L....................	0	71	119	180
+5176	PF05349	GATA-N		GATA-type transcription activator, N-terminal 	Finn RD	anon	DOMO_DM03585	Family	GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain  congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical  zinc finger. This family represents the N-terminal domain of the family of  GATA transcription activators.	20.30	20.30	20.60	20.30	19.50	20.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.77	0.71	-4.10	16	190	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	48	0	70	154	0	155.00	39	41.19	CHANGED	MYQo....LAluuspG.s..uYs.ss.GuFlHS.........s..AoSPVYVPToR.VsoMl.sLP.....YLQsstsuppu.................ps..huuHsuWuQs.uu-os.uassuS................sHsPsu.......Fsau.pSPPhuuuuu....RDsu.............YpusLhhss.u...R.-QYush..sRsluGSYsSs......YsAYhoP-lu...s.SW......suGPFDuSV.LHuLQuRs.ushsu.R+ssh..-hL	..................................................................................MYQo....LAhsus...u.s....uYt.ss...usF.hHu...........s..usSPVYVPosR.Vsuhh.sLs.....Y.Lpsstsu.ts.....................ts...supssWs.Qs.us-us.sass.....................ssst.......F.sas...os.....s..hss.usu......R-su...............apu...sh.....u....R.-QYut....RshsGoYsos..........Ys.....s.Yhu...s.slu...s.uW.......suGPF-.usV.LHuLtuRs.ss.ss.Rtssh...............................................................	1	4	12	30
+5177	PF05350	GSK-3_bind		Glycogen synthase kinase-3 binding	Finn RD	anon	Pfam-B_18811 (release 7.8)	Family	Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four  serine residues on glycogen synthase (GS), in the sequence  SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the first  serine in the sequence motif SxxxS(P) (where S(p) represents a  phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of  beta-catenin by GSK-3 [1]. 	25.00	25.00	26.70	32.10	22.90	24.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.62	0.70	-4.89	4	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	38	10	34	79	0	160.30	40	81.67	CHANGED	MPCR+E.................SFLLLpQSVTlG.SsEVDpLVupIGEsLQLcsApcoPsSssts.G........hhAuhPss+uGs..................ssGuhRChhhcptpVR.GRuuPYsVs.sssGuSshs.p.h.................t.C+RGWhR..sssR+.........ts+stD-DDPHcLLQpLlLSGNLIKEAVRRLp.....huucsPsps.PGsh	...............................................MPst+c.............................salLLpQSVTls.StEVDtLVspIGEsLQLcssps.s.t.o.ss..G..............ush.sspst.............s..........tshtChhhcptthR.sRuuPY......sGsos................................+sW.R.......+c......................t.s+ss-.DDPH..cLLQpLlLSGNLIKEAVRRLp.t.................h.............................................	0	5	6	12
+5178	PF05351	GMP_PDE_delta		GMP-PDE, delta subunit	Finn RD	anon	Pfam-B_13828 (release 7.8)	Family	GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35).  The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues.  PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport [1].	25.00	25.00	30.20	30.10	18.20	18.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.85	0.71	-4.42	23	362	2009-09-11 15:38:04	2003-04-07 12:59:11	6	4	137	20	215	325	4	144.60	44	72.54	CHANGED	pspsNlasI-Fs+FpIRDhETGpVLFEls+ssss...........................................tt..p...ssuRhl+YpFsPpa.....................L+l+oV....GAs.lpFoV.G-cPlpsFRMIERHYF+spLLKoFDF-FGFCIPpScNThEpIYEhPslupphhppMlpsPaETpSDSFYFV-s+LlMHNKA-YuYs	....................spt.lhtlchspFplRDh-oGpVLFcls+s.ss........................................................................tsGRhlcYpFssth...........................L+h+sV....u..sp.lpFos.uscslpsFRhlERHYF+sp..lL+.....sa-F-FGFsIPs.SpNThEplYEhP.shSpth.tphlps..psps-ohaFs.-spLlh+s+sch.Y.......................................	0	80	100	155
+5179	PF05352	Phage_connector		Phage Connector (GP10)	Finn RD	anon	Pfam-B_13828 (release 7.8)	Family	The head-tail connector of bacteriophage 29 is composed of 12  36  kDa subunits with 12 fold symmetry. It is the central component  of a rotary motor that packages the genomic dsDNA into pre-formed  proheads. This motor consists of the head-tail connector, surrounded  by a 29-encoded, 174-base, RNA and a viral ATPase protein [1,2].	25.00	25.00	31.80	30.90	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.89	0.70	-5.19	4	23	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	22	39	0	24	2	271.50	30	88.42	CHANGED	SYKo....Is-IQRp+....tNR..WFhaYhpYLhSLAYQhFEWEsLPsolDP.FLEKplHQhGaVuFYKDshhGYIAspGsLSGplshYNQPshap...ASSssYQKpFcLY.....Yc...Dh+Ecs.G......lVIYNNshthPTlshLELFAtcLAELKEhItVNQNAQKTPVlItAsDNN.LShKplYNpYEGNtPVIFspcphD..........oDsIcVFKTDAPYVlDKLsspKpsVWNEhMTFLGIpNANh-KKERhVsSEVpSNs-QIpuSuslaLKuRpEACchINEhYGLNlpVKhRh-IV	....................................................h...............................p..lpshhhplFpaEshPsslssh.LEp.l+Q.G.hVshh+Dthhs.hlhh.tshssthshYsp..s..shFp......uss.sa.pph...clhp....ap...chp.ps.s..............VVhhN....Nsh.hs.ssh-llEaYspcLA-lcto.hplNhpsp+sPhhItus-sN...plSlppLhsclpsGsPhl..hspcshs..........sDs..I-lh....s.ssssshls.cLppphpsphsEhhTaLGIpNssh-KKERhlscEApSNsphlpususIYhKuRpcAlchlNctYGLsIKsp.................	0	0	0	0
+5180	PF05353	Atracotoxin		Delta Atracotoxin	Finn RD	anon	Pfam-B_30981 (release 7.8)	Family	Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing he inactivation of voltage-gated sodium channels [1].  The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix.  The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides [1].	25.00	25.00	35.00	76.10	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.72	0.72	-4.12	5	7	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	3	0	8	0	42.10	65	76.62	CHANGED	CA+KRuWCuKTEDCCCPMKCIYAWYNQQSSCQsTISulFK.cC	CA+KRsWCuKsEDCCCPMKCIYAWYNpQuSCQsTIoulaK.cC	0	0	0	0
+5181	PF05354	Phage_attach		Phage Head-Tail Attachment	Finn RD	anon	Pfam-B_59968 (release 7.8)	Domain	The phage head-tail attachment protein is required for the joining of phage heads and tails at the last step of morphogenesis [1].	20.80	20.80	20.90	22.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.38	0.71	-4.53	6	548	2012-10-01 22:58:23	2003-04-07 12:59:11	6	2	289	2	4	217	26	112.70	74	98.42	CHANGED	MuDFDNLFDsAlutADcsIlcsMGhsAslTSGpLpGuplsGVFDDPEsISaAuuGlRlEsSsPoLFVKTuslspL+RsDTLTIss-sFWVDRIoPDDGGSCaIhLsR.GpPPsssRRR	..............................MtDFpNhFDAAlAtsDcTIhthMGhS..AphT..SGtQsGu.lpGVFDDP.EsluaAGpGVRlEGSSPSLFVRTDsVRtlRRGDTLTIstE......sFWV.....DR.lSP.DD.GGSC.....aLWLs..R..G.PPAVNRRR.....................	0	0	0	1
+5182	PF05355	Apo-CII		Apolipoprotein C-II	Finn RD	anon	Pfam-B_6456 (release 7.8)	Family	Apolipoprotein C-II (ApoC-II) is the major activator of lipoprotein lipase, a key enzyme in the regulation of triglyceride levels in human serum [1].	22.10	22.10	22.10	24.50	18.80	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.69	0.72	-4.11	6	40	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	29	4	19	42	0	73.00	46	75.96	CHANGED	AphsQQDEssSPALLsphQESL.SYW-SAKAAAQcLYpKTYLPAVDEKIRDlYSKSTAAlSTYAGIFTDQlLShL+G-	............p.sQpDE.sSsuLLopVQESLhSYW-oAKssApsLYcKTYlsslDEKlRDhYSKoosAhoTYsGIhTDQlhplLtGc....................	1	1	2	6
+5183	PF05356	Phage_Coat_B		Phage Coat protein B 	Finn RD	anon	Pfam-B_51500 (release 7.8)	Family	The major coat protein in the capsid of filamentous bacteriophage forms a helical assembly of about 7000 identical protomers, with each protomer comprised of 46 amino acid, after the cleavage of the signal peptide.  Each protomer forms a slightly curved helix that combine to form a tubular structure that encapsulates the viral DNA [1].	25.00	25.00	28.90	28.70	23.60	22.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.82	0.72	-4.29	2	14	2012-10-01 20:22:05	2003-04-07 12:59:11	6	1	13	15	2	14	0	80.70	65	99.56	CHANGED	MKuMKppIAKFsPVtSFRNLCIAGoVTAAoShPsa.AuVIDTSuVEpAITDGpuDMpsIGGYIVGALVILAVAGLIYSMLRKA	..............MKQpIAKFsPVsSFRN..LCIAGoVT.AAoShPAF..A.....GVIDTSAVEuAIT-GQuDMcuIGGYIVGALVILAVAGLIYSMLRKA....	0	1	1	2
+5184	PF05357	Phage_Coat_A		Phage Coat Protein A	Finn RF	anon	Pfam-B_7225 (release 7.8)	Domain	Infection of Escherichia coli by filamentous bacteriophages is mediated  by the minor phage coat protein A and involves two distinct cellular receptors, the F' pilus and the periplasmic protein TolA.  These two receptors are contacted in a sequential manner, such that  binding of TolA by the extreme N-terminal domain is conditional on a  primary interaction of the second coat protein A domain with the F'  pilus [1].	20.80	20.80	22.80	23.00	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.11	0.72	-4.39	3	41	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	15	21	0	89	0	63.30	45	24.64	CHANGED	MKKllhAlshslPFYTH.........sATTsssCLuKPuhEsSho.NVWK-sco..RYANaEGCLashTGlVlss	....hpK...hhshslPhYoa............susspcsC.uK..............P....shEsShs.Nsap.sps..RYtNapGCLasATGVVVss....	1	0	0	0
+5185	PF05358	DicB		DicB protein	Bateman A	anon	Bateman A	Family	DicB is part of the dic operon, which resides on cryptic prophage Kim. Under normal conditions, expression of dicB is actively repressed. When expression is induced, however, cell division rapidly ceases, and this division block is dependent on MinC with which it interacts [2].	25.00	25.00	25.30	37.10	20.80	19.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.78	0.72	-4.49	3	416	2009-09-11 11:17:21	2003-04-07 12:59:11	6	1	215	0	1	106	0	61.40	74	95.88	CHANGED	METLLPNVNTSEGCFEIGVllSNKsFTEDAINpRKhEp-LLN-lCIlSMLARL+Lh.KGp+Q	METLLPNVNTSEGCFEIGVplSN.sFTEDAINpRKaEp-LLNclCIlSMLARL+Lh.KGptQ...	0	1	1	1
+5186	PF05359	DUF748		Domain of Unknown Function (DUF748)	Yeats C	anon	Yeats C	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.73	0.71	-4.21	168	1412	2012-10-03 05:41:17	2003-04-07 12:59:11	6	20	431	0	618	1573	145	150.40	17	38.87	CHANGED	htlplsplplp.s.upl..pasD.....pphs..shp..hplpsLshpl.sslu.ot.s.sp......sslp..l....puplspt...uslphpGpls..shs.hpsp..lplshc...slsLsshpPY.hsph.hshplppGpLsh....cLphp....hp.ps.pl.pspsplt..lc....pLp..ls-.....ps.ss.....pshh...sLs....l	.........................................................................................lplsplplp.s..Gpl....papD...............tthp...shp......hplsslsh....sl...ssl..s..sh....s...sps.....................sslp....l...................pup.lsst...................uslshpGpls.........shs....php.........hplphp..slsLs.s....hp.sY....hsp.......h.....h.......sh....pl..p....p..GpLsh.......clphp........................hp.ps..pl..p.s...p...s...p.lt..ls....plp..ltp.....t..ps...................hh..........................................................	1	137	349	518
+5187	PF05360	YiaAB		yiaA/B two helix domain	Yeats C	anon	Yeats C	Domain	This domain consists of two transmembrane helices and a conserved linking section.	20.40	20.40	20.40	20.50	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.30	0.72	-4.42	19	1736	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	843	0	190	635	32	52.40	37	64.76	CHANGED	ahshsasuhlluhshhhlGlasus.hpLstKGaahhshhhslhuslslpKssRD	..........ahhhuhhshllulshhllGLW.sus...h...hLuEKGYahsslhhulFushuhQKshRD......	2	43	112	151
+5188	PF05361	PP1_inhibitor		PKC-activated protein phosphatase-1 inhibitor	Finn RD	anon	Pfam-B_69711 (release 7.8)	Family	Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction [1].	20.70	20.70	21.10	22.10	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.88	0.71	-4.51	8	231	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	78	4	125	200	0	108.80	38	79.73	CHANGED	MAup+lG+Rhppp.pSss+upu..pustslQ+RpARVTVKYNRKELQRRLDVEKWIDspL-ELYpG+E--MPE.EVNID-LLDLpoDE-Ro++LpslLpuCsssTEsFIsELLt+L+GL+KQptLpppGlchPp.ph.sph............cs	............................t.........................................t......+.+..pu+lTVKYsR+cL...p+...RLslEcWI.ppLpcLYp.....s..pE.-.-.......hP-...E.....IDlD-LLDhpo--pRsp....+l.p.clL...hs....Ch...+P...T....E...s...FIp-LLs+l+Ghp+.s.......................tp................	2	18	29	61
+5189	PF05362	Lon_C		Lon protease (S16) C-terminal proteolytic domain	Studholme DJ	anon	Merops	Domain	The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.21	0.71	-5.02	25	7706	2012-10-03 01:04:38	2003-04-07 12:59:11	8	39	4472	58	2231	8849	3459	174.80	32	25.91	CHANGED	slsscsLccaLGh.+F+hspA-ccDpVGlVTGLAWTpVGG-lLsIEushhP..GKG.+LplTGpLGDVMKESApAAhSYlRS+ApchGIcscha-cpDIHlHVPEGAsPKDGPSAGlsMsTALVSsLTGhsV++DVAMTGEITLRGRVLPIGGLKEKlLAA+RuGIKpVIlPc-Nc+DL.c-lPcsl+csLclhsVcplD-VL+hALst	.....................................................................................................................h........................................................................................G...hh.s..........................................G.....h....h.........lE.....s...........................................................t.........p...............s.........t..............h..............h...o...G..........h........t.............p.......................h.......p....c.....u........h..................s...........t.....h....hp....................t.......................................................................................................................................................................................h...........t................t.....................p...h....H.lp...h...s.t...u.uh....s..h..D...G......PS..A.G..lsh..s..s..A.l...l.............S...s...L.....o...........s.......t.............s...l......c....p....s......l....A.......h...T...G-Iol...pG.c.VhPI..G.G.lcEKl........l....A........A..p.......R.......u.......G.h.......c...t...l.....l.....l......P...............p....p...............N........t.+......-......l......p..............-..............l.........s....p......t.....l..........p....p....t.h.....p.....lh.s.V.p.p.lc-slphh..t.....................................................	0	804	1468	1899
+5190	PF05363	Herpes_US12		Herpesvirus US12 family	Finn RD	anon	Pfam-B_62991 (release 7.8)	Family	US12 a key factor in the evasion of cellular immune response against HSV-infected cells. Specific inhibition of the transporter associated with antigen processing (TAP) by US12 prevents peptide transport into the endoplasmic reticulum and subsequent loading of major histocompatibility complex (MHC) class I molecules [1]. US12 is comprised of three helices and is associated with cellular membranes [1].	21.00	21.00	23.70	23.50	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-9.79	0.72	-3.47	2	19	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	1	0	19	0	80.40	53	95.56	CHANGED	MSWALchsDhFLDs.Rss.RTYuDVpsEIpKRtREDREAARTAVpDPEhPLLpsPslhs-.As....ptohGsA+pppttsts.uP	......MuWALchsDsFLDs.Rss.RTYADVRcEIsKpuRED.REAARTAVtDPERPLLpsPulhP-hAs....sAohGsA+pppttshh.uP............	0	0	0	0
+5191	PF05364	SecIII_SopE_N	SecIII_SopE; 	Salmonella type III secretion SopE effector N-terminus	Finn RD, Moxon SJ	anon	Pfam-B_18665 (release 7.8)	Domain	Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, one of these toxins, can activate Cdc42 in a Dbl-like fashion via its C-terminal GEP domain Pfam:PF07487 [1]. This family represents the N-terminal region of SopE. The function of this domain is unknown.	19.10	19.10	21.80	45.70	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.40	0.72	-4.15	2	141	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	106	0	2	45	0	70.20	79	31.04	CHANGED	TpITLSsQpaRIp+p-sp.lKEKoTEKs.hAKSIhAV+NpFIpLpopLS-RF..HppT-.ssTHFHRGsASEGR	.TNITLSTQHYRIHRSDVEPVKEKTTEKDIFAKSITAVRNSFISLSTSLSDRFSLHhQTDIPTTHFHRGSASEGR...........	0	0	0	1
+5192	PF05365	UCR_UQCRX_QCR9		Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	Finn RD	anon	Pfam-B_18986 (release 7.8)	Family	The UQCRX/QCR9 protein is the 9/10 subunit of complex III, encoding a protein of about 7-kDa. Deletion of QCR9 results in the inability of cells  to grow on grow on-fermentable carbon source n yeast [1].	20.40	20.40	20.40	20.70	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.59	0.72	-4.33	33	239	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	211	52	166	258	1	53.30	36	49.35	CHANGED	hsslYpslFRRNSsalssIhsGAFsFEh.AFDsusspla-shN+GKhWKDI+tcY.	......h.ptlYphlh+RsSsassslhsGAFhFEt.uaDtusspla-phN+GKhWKDI+tph......	0	51	86	138
+5193	PF05366	Sarcolipin		Sarcolipin	Finn RD	anon	Pfam-B_33603 (release 7.8)	Family	Sarcolipin is a 31 amino acid integral membrane  protein that regulates Ca-ATPase activity in skeletal  muscle [1].	26.40	26.40	26.80	65.70	20.60	26.30	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.43	0.72	-4.54	2	17	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	17	1	9	12	0	30.60	87	100.00	CHANGED	MthsTpELFlNFTlVLITVlLMWLLVRSYQY	MthsTRELFLNFTlVLITVILMWLLVRSYQY	0	1	1	1
+5194	PF05367	Phage_endo_I		Phage endonuclease I	Finn RD	anon	Pfam-B_22152 (release 7.8)	Domain	The bacteriophage endonuclease I is a nuclease that is selective  for the structure of the four-way Holliday DNA  junction [1].	25.00	25.00	25.60	25.40	22.60	21.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.73	0.71	-4.81	6	64	2012-10-11 20:44:44	2003-04-07 12:59:11	6	1	59	24	2	65	330	136.50	49	98.32	CHANGED	MA..uahAKthppVtAaRSGLE-KsuKQLEuKGlKh-YEpahlPYVlPASsH+YTPDFlLPNGIhVETKGLa-o-DRKKHLLIREQHPELDIRhVFSSSRTKLYKGSPToYu-WCEKaGhpFADKLIPVtWL+EsspclPhshLKsKKGcK	.........................................thtts.uaRSGLE-+lucpL-spGlpa-YEphclsYllPtp.sHpYTPDFlL.P.N..G..IhlEoKGha........-s-DR+KHLLI+EQaP-.L.DIRhVFSsSpo......KlYKGS.ToYu-WC-KaGhha.A.D.K....h.IPs-WL+E.ph.hs.shhh.ht........................	0	0	0	1
+5195	PF05368	NmrA		NmrA-like family	Finn RD	anon	Pfam-B_25329 (release 7.8)	Family	NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi [1].  This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.33	0.70	-5.11	25	4570	2012-10-10 17:06:42	2003-04-07 12:59:11	8	40	1637	75	2377	19410	5486	230.00	20	76.81	CHANGED	ILVlGuTGh.GptlVcAulc.....sGapshALsRcs.................cschhpshpstGspll.pGD.ls...........................-+pSLscAlKtVDlVhssss........stpltpthpllcAhKcAG.VK+Fl.Sphuscsc..tspuh.PuhstF-pKtplc+hlcut......GIPaTaVhsshFss.Flsshst...ttsssspsphslhususscslhh...sEcDlGsaslpslcD.Pcph.pshhlphssshLohsElsslapKt...lGKs.........................................................V+Ysp	...................................................................................................lhlhG.A.T...G.p...h...G...t......t...l....l.c.......s.L.lp....................ss...h......p.....l...h.......s.....l.......s...R..ss............................................................p.p..........h...p.....t.....l.......t........t......t.......G.......s..........p........l.......h......p......u..D...h...s................................................................................s........s...u....L........t...p.....A.....h........p............G.......s.......-.......s......l........h...h..h...s..s...................................stch.....t.......p.....t......t.........s......l....l.......c.........A...........A....p........p...........A.......G.....V.....c.........+........h..........l..............h..............o..........s.........h.........s........t.........s........s.........t..............s...........................................................................h........s...........h........h.....s............t.........+......h....p.......h....c....c....h...l.....p.pp........................s.l...s...a....T...h..l......p........s.....u.......h.......a...h.............c................h.......h...s.....hh........................h.t....t............................h.......h.....h.h......s......s...s..s....t..hshh.....................sttD.h...u....t....h....s....s.t........l....l....p.............p.....s.....t....p.......h....................s.....p....h...h.........h.....s...s..........p........t........h........o......h.p......c.l.sthhpch....h..G..pp......................................................................................................................................................................................................................................................................................................	0	562	1309	1950
+5196	PF05369	MtmB		Monomethylamine methyltransferase MtmB	Finn RD	anon	Pfam-B_58618 (release 7.8)	Family	Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG [1,2]. The structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold [2].	25.00	25.00	148.90	148.60	16.50	16.50	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.52	0.70	-6.32	3	22	2009-09-11 12:54:46	2003-04-07 12:59:11	7	1	14	0	15	29	4	418.70	52	99.42	CHANGED	TFRKSFDCYDFYDRAKVGEKCTQDDWDLMKIPMKAMELKQKYGLDFKGEFVPTDKDMMEKLFQAGFEMLLECGIYCTDTHRIVKYTEDEIWDAINNVQKEFTLGTGRDAVNVRKRSVGDKRKPIVQGGPTGSPISEDVFMPVHMSYALEKEVDTIVNGVMTSVRGKuPIPKSPYEVLAAKTETRLIKQACAMAGRPGMGVXGPETSLSAQGNISADCsGGMpSTDSHEVSQLNELKIDLDAIAVIAHYKGNSDIIMDEQMPIFGGYAGGIEETTIVDVATHINAFVMSSASWHLDGPVHIRWGSTNTRETLTIAGWACATISEFTDMLSGNQYYPCAGPCTEMCLLEASAQSITDTASGREILSGVASAKGVVTDKTTGMEARMMGEVARATAGsEISEVNKILDKLVuLYEKNYASAPAGKTFQECYDVKTVTPTEEYMQVYDGARKKLEDLGLVF	...................tKphssYDaaDRA+sGEKsopDDW..DlMpIPhKuhELKpKYsl-F.c.s.E.FlPTDcDMh-+LFpAGhEMLlECGIYCTDTcRllKYTEDEIh-AIsNs.KEasLGpG+DulsVhcRuhsDp...p...tPllQGGPTGuPlSEDlFhslHhSYAhE..VD.sI.VsGVhpolpG+sshPtSPaElhAu+oEsRLlKpAsthAGRPGMultGPETuloupGsl.uuDssGGhspsDSHEVSQLsELKIDl-AlshhAHYpssuslIMsEQMPIFGGYA.GGl.EETsIVDVATpINuhlMosAoaHLDGPVHlRWGSTsTREsLhlAGassusloc...Tch..lsGNQYYssAGPCTEMCLLEsuAQuITDTASGRElLSGVAuAKGVssD+oTGhEARhMGElARAsAGh-lo..ElNtIL-+LVuhYE...c...sassAPt...GKsFpECYDVpT...lsPT-EYhplYDtAtKcLc-lGL..............	0	5	10	11
+5197	PF05370	DUF749		Domain of unknown function (DUF749)	Finn RD	anon	Pfam-B_54547 (release 7.8)	Family	Archaeal domain of unknown function.  This domain has been solved as part of a structural genomics project and comprises of segregated  helical and anti-parallel beta sheet regions.	25.00	25.00	74.80	74.60	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.58	0.72	-4.04	5	27	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	27	2	19	26	2	87.80	44	89.91	CHANGED	FlAsLlGIhTlKE.LsEEhcsFV+lKAulDK+ELcDDsclAIlNIcGTTSYaVlFLDsssSlEEI++ELEEs..GAclN+sScpIL++aL	FlAsLluIhslcE.Lss.EhpsaVcl+Aul-cR.EL.ccsDplAILNIpGTsSYpVhFlDp.ssI-cIKc-Lcch..sAclNasSccIl+pal	0	4	9	15
+5198	PF05371	Phage_Coat_Gp8		Phage major coat protein, Gp8	Finn RD	anon	Pfam-B_31655 (release 7.8)	Family	Class I phage major coat protein Gp8 or B.  The coat protein  is largely alpha-helix with a slight curve [1].   	19.80	19.80	19.80	21.50	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.63	0.72	-4.41	7	29	2012-10-01 20:22:05	2003-04-07 12:59:11	7	1	21	13	4	45	1	51.20	51	69.77	CHANGED	AEssss...AptAhDSLpspAT-hIu.sWshVsslVsAsluIKLFKKFsSKA	......................ss.....AtsAhDuLtspAs-hIGhsWslVVslVGAsluI+LFKKFoSKA	0	0	3	3
+5199	PF05372	Delta_lysin		Delta lysin family	Finn RD	anon	Pfam-B_45919 (release 7.8)	Family	Delta-lysin is a 26 amino acid, hemolytic peptide toxin secreted  by Staphylococcus aureus. It is thought that delta-toxin  forms an amphipathic helix upon binding to lipid bilayers [1]. The precise mode of action of delta-lysis is unclear.	25.00	25.00	62.60	62.50	17.80	16.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.34	0.72	-6.77	0.72	-4.58	6	86	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	79	3	2	18	0	25.00	94	64.33	CHANGED	MAuDIISTIuDFVKLIl-TVpKFTK	MAQDIISTIGDLVKWIIDTVNKFTK	0	1	1	2
+5200	PF05373	Pro_3_hydrox_C		L-proline 3-hydroxylase, C-terminal	Finn RD	anon	Pfam-B_32425 (release 7.8)	Domain	Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes.  Proline 3-hydroxylase  hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure contains conserved motifs present in other 2-OG oxygenases including a  jelly roll strand core and residues binding iron and 2-oxoglutarate,  consistent with divergent evolution within the extended family.  The structure differs significantly from many other 2-OG oxygenases in possessing a discrete C-terminal helical domain.	25.00	25.00	26.90	26.30	20.50	18.40	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.21	0.72	-3.98	5	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	4	5	15	0	100.30	26	34.00	CHANGED	spcEshtDsE..sssssPsVcsRKPaT-EscEuILu.lStlIu+tNFRDIVFlLSKlHFpYKVHssEsYDWLlEIuKRsGD-cLVEKAppl+RFhltcRAlGE	...................hshp..ssthpstlssRsths-pphEpLlu.lSplloctNaR-llhhLuKlHFp+-sssspsaDWLp-lA+RoGDsAllpKAcplRcahlpcRshsE.........	0	2	4	5
+5201	PF05374	Mu-conotoxin		Mu-Conotoxin	Finn RD	anon	Pfam-B_34209 (release 7.8)	Family	Mu-conotoxins are peptide inhibitors of voltage-sensitive sodium channels [1].	19.30	19.30	20.50	20.40	18.20	14.80	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.30	0.72	-4.14	4	7	2012-10-01 22:06:18	2003-04-07 12:59:11	7	1	5	6	0	12	0	21.60	60	58.75	CHANGED	RDCCTPPKKCKDRpCKPh+CCA	..R.CCssPKpC+sRpCKPp+CC.	0	0	0	0
+5202	PF05375	Pacifastin_I		Pacifastin inhibitor (LCMII)	Finn RD	anon	Pfam-B_35181 (release 7.8)	Family	Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors [1,2]. 	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-8.66	0.72	-4.44	36	190	2009-01-15 18:05:59	2003-04-07 12:59:11	8	32	46	12	121	244	4	37.20	36	11.86	CHANGED	pC..sPGpsaK.p-..CNsCpCstsGh...ssCTh+uC.st.httsss	.............sGpsa+..pD..CNsCpCs.sGp...hsCTpphCsst......s.......	0	66	91	112
+5204	PF05377	FlaC_arch		Flagella accessory protein C (FlaC)	Studholme DJ	anon	Manual	Family	Although archaeal flagella appear superficially similar to those of bacteria, they are quite distinct[1]. In several archaea, the flagellin genes are followed immediately by the flagellar accessory genes flaCDEFGHIJ.  The gene products may have a role in translocation, secretion, or assembly of the flagellum. FlaC is a protein whose exact role is unknown but it has been shown to be membrane-associated (by immuno-blotting fractionated cells) [2].	27.00	27.00	27.00	33.50	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.53	0.72	-4.07	10	60	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	54	0	41	64	2	55.90	39	17.60	CHANGED	RlsELENcls+lsss...lsol++ENp-l+sslEcl-EsV....+-llsLYElVSp...plNP.Fl	..............RlsElEscls+lcss...lssl+pENcpl+csl-cl--sl....+clhsLYElVSp...pINP.Fl..........	0	5	21	32
+5206	PF05378	Hydant_A_N		Hydantoinase/oxoprolinase N-terminal region	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of the Pfam:PF01968 family.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.01	0.71	-4.76	64	2308	2012-10-02 23:34:14	2003-04-07 12:59:11	8	31	1319	0	1145	2398	1126	178.40	28	21.44	CHANGED	plGIDhGGTaTDslhhctsp......................thltshKlhoo......csshpGlppulpphttp.........hsplshlhhuTTluTNAlLEpcG............spsuLlsstGapDhlphshttp.th................ps.h.hc.hltlstRhss.c............................Gp.lpsl.D.ptlcphlpplpsptlpulAVshhaShtNPpHEhpltcllcchs	..................................lulDhGGTFTDslh...hcss....................................................stltshKl.os.........................cs...sspGlhpslpphh.tp..h.t..................hspls.......t..lthGT...........T...luTNAllER+G............s+s.u.Ll..s.o..p..G.a.c.D.h.lt.l.s..p......p..t...p..s..ph......as.....h...............................s...h.hhp..p.......hh..t.l.spRlsh.c.................................................................G.pll.p.sl...-.t.p.p.lcpt.l.p....p.l....t....s.........p..G..lc..ulAlshhaSa..t............p...s..p..H..Etpltclhpc..h.........................................................................................................	0	363	745	976
+5207	PF05379	Peptidase_C23		Carlavirus endopeptidase 	Studholme DJ	anon	Manual	Domain	A peptidase involved in auto-proteolysis of a polyprotein from the plant pathogen blueberry scorch carlavirus (BBScV)[1]. Corresponds to Merops family C23. 	25.00	25.00	33.70	43.10	24.50	22.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.85	0.72	-4.01	12	125	2012-10-10 12:56:15	2003-04-07 12:59:11	6	8	50	0	0	124	0	87.30	35	5.41	CHANGED	.KNsCVIcAlupslpRpsscllpVLpcpsscclhc-ltpGtGlphhpLp.lFpsFDIsApVs.suchhhlNspGphptpFtlps-HhSa	....hNsCslpAlAsALsR+ps-VLslLscsss.sclh-pLtpGtGlshhhLtphFchFsIsAplshsGchhllNspG+lpuhFclps-Hlpa..	0	0	0	0
+5208	PF05380	Peptidase_A17		Pao retrotransposon peptidase 	Studholme DJ	anon	Manual	Family	Corresponds to Merops family A17. These proteins are homologous to aspartic proteinases encoded by retroposons and retroviruses.	20.60	20.60	20.60	20.60	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.17	0.71	-4.38	8	650	2009-01-15 18:05:59	2003-04-07 12:59:11	8	62	40	0	609	764	6	127.10	25	12.22	CHANGED	PTKRElLSplu+lFDPLGhluPlhl+uKlhhQElWpps......luWD-plPp-lppcWtsalcpLssLpQlRlPR.alshssspslpLHuFsDASpcAYuAAlYhRs.p.sssIpVsLlsAKTRVAPlKss.SIPRLELsAAlLLoRLssslpsphshtsschhsWT	.................................................................o+Rtlhs.huphaD.PhGhhss..........hhl.hKhhhp.plhpt.t..........hsWc..p...ls..t..ph.......ppW.thhp..ph.......t.......p.t.h..p.hs...R...h..h.................t........t......p......h...p...lh...hFsDAS.p..tuausss....Ylhh..........t.t..t......s.p.h.lh..uKs+l.tP..h..c...t........ol..P.....+hEL.uh.hssph.....l.pth..t........................................................................	0	393	436	605
+5209	PF05381	Peptidase_C21		Tymovirus endopeptidase	Studholme DJ	anon	Merops A17	Family	Corresponds to Merops family C21. The best-studied plant alpha-like virus proteolytic enzyme is the proteinase of turnip yellow mosaic virus (TYMV). The TYMV replicase protein undergoes auto-cleavage to yield two products.  The auto-peptidase activity has been mapped to the central part of this polyprotein.	25.00	25.00	34.00	50.10	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.22	0.72	-3.93	13	44	2012-10-10 12:56:15	2003-04-07 12:59:11	7	4	32	0	0	51	0	105.50	35	5.58	CHANGED	Ps.hsCLLoAlSspT+lSc-cLWcoLpslLPDS.LsNpElsoLGLSTDHLTALAahYshpsslaSscGslhaGlpsupppIsIoHTsGPP....uHFSs...hh.tssshsG	.....PthsCLLsAlSstTslo.cpLWpsLsshLPDSLL.ssp-lsshGLSTDHhssLAahaphpsphhospt.lphGlpsAopphpIpHTsGss.......sHFsh...h........sss.........	0	0	0	0
+5210	PF05382	Amidase_5		Bacteriophage peptidoglycan hydrolase 	Studholme DJ, Garcia E	anon	Pfam-B_6845 (Pfam7.8)	Family	At least one of the members of this family, the Pal protein from the pneumococcal bacteriophage Dp-1 Swiss:O03979 has been shown to be a N-acetylmuramoyl-L-alanine amidase [1]. According to the known modular structure of this and other peptidoglycan hydrolases from the pneumococcal system, the active site should reside at the N-terminal domain whereas the C-terminal domain binds to the choline residues of the cell wall teichoic acids [2,3].  This family appears to be related to Pfam:PF00877.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.81	0.71	-4.58	8	235	2012-10-10 12:56:15	2003-04-07 12:59:11	8	30	204	0	32	361	31	134.80	28	32.91	CHANGED	shEpuIAWMtARKG+.VoYSMs.hRsGPsSY.DCSSSVYhAL+uAGASsuGWhlNTEhhHsWLhcNGacLIucNtsWsApRGDIhI..WGt+.GuSuGAGGHsGMFIDusNIIHCNY...usNGIoVsNasppshhuGthhsYlY..Rhssuuoss	.................................p..p.hltah.....t.p..c.sp..l.s..YS..M....R.G.....ss...u.......h....DCSuu..lhh.A..Lp.t.u.Gh......s..s.......u.h..h.s......s..Tpshhs.L..p.p..sG..a.ppl.s.....p...s...............h.......s....s....pcGDIhI..hGtp...GtSuG.s.sGHsslh...h....s..t....s..p...hIps...s..h..........s.s.s.............................................s..........................................................................	1	13	19	26
+5211	PF05383	La		La domain	Bateman A	anon	Bateman A	Domain	This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins [1]. The function of this region is uncertain.	21.30	21.30	23.30	21.90	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.81	0.72	-4.17	33	1403	2009-01-15 18:05:59	2003-04-07 12:59:11	12	36	318	14	875	1319	11	58.80	37	10.47	CHANGED	lh+QlEYYFSDpNLspDpFL+pphsc..-GaVPlpllusFp+l+pLo..............hphIlpAL+pS	.........lt+QlEaYFS......cpNLs+.DtFL....hpph....c....p..........-......G....a.....VPlpllss.Fp+l+pLo...............sDhphlhcAL+pS...............................	0	260	430	669
+5212	PF05384	DegS		Sensor protein DegS	Moxon SJ	anon	DOMO:DM08518;	Family	This is small family of Bacillus DegS proteins.  The DegS-DegU two-component regulatory system of Bacillus subtilis controls various processes that characterise the transition from the exponential to the stationary growth phase, including the induction of extracellular degradative enzymes, expression of late competence genes and down-regulation of the sigma D regulon [1]. The family also contains one sequence Swiss:Q8R9D3 from Thermoanaerobacter tengcongensis which are described as sensory transduction histidine kinases.	24.20	24.20	24.60	26.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.73	0.71	-5.02	21	178	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	173	0	64	164	0	156.90	37	40.64	CHANGED	DcIlpchlcslpcSKc-IFcIuEpuRpEapcLppELcplKpclsclIpcsDcLEhppRhARpRLsEVS+pFppYSEp-I+cAYEpAcplQlcLslhRpcEppLRcRRD-LEpRLhslpcTI-RAEpLluQluVsLsaLsuDLcpluctlE-hpp+QphG	..........DpIlpchlcsl-sSKppIFpIuEpuRpEhcpLpcELcplKppltclIcplDpLEhpp+puRpRLsEVS+sFpcaSEc-I+pAYEcAcclQlcLshh+p+EppLRpRRD-LERRLtslpchlERAEpLluQlsVlLsYLssDLppls.hl-shpp+Q.hG.................	0	32	53	57
+5213	PF05385	Adeno_E4	M_adenovirusE4; 	Mastadenovirus early E4 13 kDa protein	Moxon SJ	anon	DOMO:DM07617;	Family	This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9 [1].	25.00	25.00	31.00	31.00	23.30	19.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.51	0.72	-4.10	8	88	2009-09-11 08:31:06	2003-04-07 12:59:11	6	1	68	0	0	64	1	107.20	50	90.15	CHANGED	MsLPsLPsPPVscDpuuCIuWLGLAauollDllRsI++cGlhIoPEAEplLsuLREWLaauapTERp+R+DRRRRslCpuRTaFCapKYEpVR+pLh.YDssppTlSl..ts	....MlLPsLPsPPl.c-ppuCIsWLGhAYsslsDVlRsIRh-Glhlos-ApcLLpsLREWLYauahTERp+R+..D.RRRRtlCsuRstFCapKY-pVRKplH.YsssppTlslt.s......	0	0	0	0
+5214	PF05386	TEP1_N		TEP1 N-terminal domain	Bateman A	anon	Bateman A	Domain	This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain.  However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.	25.00	25.00	25.60	25.00	24.30	16.80	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.37	0.72	-4.49	8	102	2009-01-15 18:05:59	2003-04-07 12:59:11	6	16	20	0	38	89	0	29.80	72	4.25	CHANGED	hEKlHGHlSsHPDILSLENRCLshLPDLQP	..MEK.HGHVSAHPDILSLENRCLATLPDLKs......	0	4	4	4
+5215	PF05387	Chorion_3		Chorion family 3	Moxon SJ	anon	DOMO:DM07741;	Family	This family consists of several Drosophila chorion proteins S36 and S38. The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary [1].	21.20	21.20	21.20	21.50	21.10	20.70	hmmbuild  --amino -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.97	0.70	-4.96	4	75	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	25	0	19	73	0	201.60	45	88.03	CHANGED	Mspa.alLhlsAssL..........ApAuYGusGuuG.GhGuuthuAuuuA......tsusGGst.SG..........GshpuusApl.spPspsu+lspsQuphtu.p.s.sYp.hhppusslupSls.sp................................NptpllhppP.sPIIV+pP..PsphlsstPPhVVKsAPVlh+h.PuVlhpp.hlp+hPpPlplpPVYVpVhKPst..Et.hVstspQsYtpsuaGsSphSt............GYGuusutuusAuuAuStusupA	...hsh..hlhAlAA.s.l.........sSANYGsstu.....tu...Gptht.h..ussss...tthsssAsGGstsuu...........p.hsupAth...ps.s.s-tAthhttsQuphtu.p.s.sYp.h.ppupslspSls.sp...............................pNptpllhppP.sPIIV+pP..PsthlsstPPhVV+ssPVlh+h.Pullhpp.hlp+hPp.lplpPVaVpVhKPst..Et.hss.st.sYsQ.s.......p.htt..................uautu.stu.tstsssst.....s...............................................	0	2	2	11
+5216	PF05388	Carbpep_Y_N		Carboxypeptidase Y pro-peptide	Moxon SJ	anon	DOMO:DM08350;	Family	This family is found at the N terminus of several carboxypeptidase Y proteins and contains a signal peptide and pro-peptide regions [1,2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.68	0.71	-3.91	6	94	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	88	0	65	87	0	107.80	26	20.30	CHANGED	M+LosSlL..suLAhshssApALul......QpPlu.......................h..ttpsll-psucslu......-sLcslsspl+shWsEMthpFPsplspLpapopPKhtlstKsss..WDF...........pVpssplsNY+L	............................................................................h....hs.st.Ahsh............Qp.ht.................................htpsh..hppht...ctht...........-.lc.sLos-s+slWsElthhaPcs....h.pphp...h...h...o...tPK..ts++scsc.WDa...........lV+su...cl...............................	0	13	34	58
+5217	PF05389	MecA		Negative regulator of genetic competence (MecA)	Moxon SJ	anon	DOMO:DM05333;	Family	This family contains several bacterial MecA proteins. The development of competence in Bacillus subtilis is regulated by growth conditions and several regulatory genes. In complex media competence development is poor, and there is little or no expression of late competence genes. Mec  mutations permit competence development and late competence gene expression in complex media, bypassing the requirements for many of the competence regulatory genes. The mecA gene product acts negatively in the development of competence. Null mutations in mecA allow expression of a late competence gene comG, under conditions where it is not normally expressed, including in complex media and in cells mutant for several competence regulatory genes. Overexpression of MecA inhibits comG transcription [1,2,3].	21.10	21.10	22.10	21.50	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.32	0.70	-4.80	42	1309	2009-09-11 15:15:24	2003-04-07 12:59:11	7	2	1134	28	147	674	7	222.50	30	97.79	CHANGED	MclERIN-sTlKlhIoh-DLp-RGhshpDlhhspc+sEchFashh-Elcp-csFps.sGslshQVhshp.pGl-lhlTKsp.....pt..t....................ptss-plpchlcpph..............................t-hcspl-.............................hllpFsshEDlIsLucplp..tslts...pLYpacspYYLtlhh...pphsptphcshluhhhEauptoshot..h.hLpEYGchlhppsAlppl+p	.......................MchE+Is-sTlKlhlohpDLp-RGhshtDlh.h.s.pc+sE-FFashh-El.....c.--.s.Fhs..sG.sL.h...h..pVhshp.cGl-VhlTKuc............cp..php...s.................................sp.ts-phpchlcppl..............t..p.........................................................p..p.t.php............................................................................ttppsthp..hl..lpFscl-Dllshu..cplph...p...t...hps..pLYp...h..s..s...c..YYLslhh.............p..p..h.sp.hhsphhuhlhEa..u...p...s...os...h...Tp..........t...hL...pEYGchlhscsAlpplp..............................................................	0	45	89	117
+5218	PF05390	KRE9		Yeast cell wall synthesis protein KRE9/KNH1	Moxon SJ	anon	DOMO:DM07408;	Family	This family contains several KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, which are required for beta -1,6-glucan synthesis in yeast [1].	20.50	20.50	21.60	21.60	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.54	0.72	-3.70	5	120	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	87	0	79	106	0	98.00	42	36.75	CHANGED	IDSKSFTVPYTcQTGKoRaAPMQhQPGTKVTATTWSRKYATSAVTYYSThsuoP-QtTTlTPGWSYTISSuVNYATPAPMPSDNGGWYsPpKRlSLoTRKlNs..hR+l	..............tsaTVPYshQT.GhoRYAPMQhQP.sT+l.T..A.p.....Ta..ohp..asT.SuVohaoT.hhs..s.ss.tTTlTsuhoYolsSt.NhAoPAPhPs-...hY....h..................h..........................	1	11	35	63
+5219	PF05391	Lsm_interact		Lsm interaction motif	Bateman A	anon	[1]	Motif	This short motif is found at the C-terminus of Prp24 proteins and probably interacts with the Lsm proteins to promote U4/U6 formation [1].	21.40	21.40	21.40	22.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.69	0.73	-6.64	0.73	-4.30	9	94	2009-01-15 18:05:59	2003-04-07 12:59:11	6	14	80	0	54	86	0	20.50	47	2.66	CHANGED	sptsssst.hSNDDFRKhFL+	..........sscss.hSNsDF+KhFL+..	0	10	20	34
+5220	PF05392	COX7B		Cytochrome C oxidase chain VIIB	Moxon SJ	anon	DOMO:DM07697;	Family	\N	20.70	20.70	22.00	39.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.79	0.72	-4.40	8	75	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	43	51	35	92	0	75.90	63	98.05	CHANGED	MFPLAKsALupLplpSIQQssARQ.uHpK+oP.DFHDKYGNulLASGusFClAsWoYssTQlGIEWNLSPVGRVTPKEW+-Q	...................MFPlu+sALspL.plRSIQQshARQ.uHpK+oP.DFHDKYGNuVLAuGAsFClusWsYssTQlGIEWNLSPVGRVTPKEW+cp...	1	2	3	9
+5221	PF05393	Hum_adeno_E3A		Human adenovirus early E3A glycoprotein	Moxon SJ	anon	DOMO:DM07622;	Family	This family consists of several early glycoproteins from human adenoviruses.	21.40	21.40	21.40	22.50	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.48	0.72	-4.32	3	49	2009-09-11 15:19:00	2003-04-07 12:59:11	6	2	27	0	1	39	0	97.20	47	42.85	CHANGED	MTsTTNA.......sTATGLTSTpNhPQVSAFVNNWANLGMWWFSIALMFVCLIIMWLICCLKRKRARPPIY+PIIVLNPNNDGIHRLDGLKsCSFSLsV	.........................t.ptss.s..ssh...............s..hTSLA.TNETsVshMasQsau....GL..D..I..T..FLVVCGIFILlVLLYFVCCKARcKSRRPIYRPVIG.......................ps..................	0	0	0	1
+5222	PF05394	AvrB_AvrC	Pseu_avirulence;	Avirulence protein	Moxon SJ	anon	DOMO:DM07798;	Family	This family consists of several avirulence proteins from Pseudomonas syringae and Xanthomonas campestris.	20.00	20.00	21.80	21.50	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.07	0.70	-5.45	6	40	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	22	4	2	32	1	292.60	48	94.26	CHANGED	MGCloSKtssluSsshpsutosSs............pt+ushhs.LpGPsptScLpsapQuLVGsARWPDct......N+sssPcphcYscShYppSRthGuSlAsGcIsSFp-LWpcAp-WRhSRhsps-sl...FuosRsPNoc..FVTPLtcPYc.lh-RhsN+pDucschhpDphFhs.csKsaR.sGpIsGEsIPLTplosusDccA..-RhpchhpcLcspuhpDh...ucPNhIsHTsAEYlPpIhcHlEsLYppAlDsuLSppcALchlAclHWWsApAhPDcRGSAAKAEhssRSIApA+Gl-LPPhRpGIVPDlEAMhhuccpFVcsY.uhFEps	.....................................................................................................................................................................................................ssh....uS.sstsuuopSp............thpushhs.LpGPsphScLo.cpQSLVGsARWPDct......N+ssT.cphcYs+ShYpuSRhAGuuIASGpIsSFs-LWpcAppWRhSRhuus-so..sFAs.RhPNoc..FVTsLppPYc.ll-RhpN+sDuchchh-sphhttlcsKsaR.pGtIsGEsIPhTplssusDcsA..sRhcsh..pc.cppthpp.httucPshIsHTsAEYl.pIhcHlEsLYhpAlDsoLpc+cAhcllAclHWWsAsAsPDcRGSAAKAEhusRSIApA+Gl-.hPPhRpGIVPDlEAMhp.SccpFVtpYsshF-p.......	1	1	1	1
+5223	PF05395	DARPP-32		Protein phosphatase inhibitor 1/DARPP-32	Moxon SJ	anon	DOMO:DM07433;	Family	This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1 [1]. It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1 [2]. DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive [3]. A mutant form of DARPP-32 has been linked with gastric cancers [4].	21.20	21.20	21.50	26.20	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.36	0.71	-4.10	12	144	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	40	0	69	136	0	129.30	42	89.78	CHANGED	MEs.pu.+KIQFoVPh.tspLDPcAsE.IRRRRPTPATLhhsS-pSSP..DE-psPp.htpsshphs.ppRpp.hshhsPohKtlQhlsEpHLpp.ushpEp.sp.tpp..sp.c.hs.sctpstpTpsp.....pSc.st.s.ppDups-s................G.pGshcpoh.ps.spccpsup....-Ps	..............M-s.ps.+KIQFsVPh....s.plsPctsE.......p........IRRRRPTPAoLhhhs-poSP..--ct.sp.......................hhp.p.ph..ppRhp.sshssPohK...tlQhhhpp.HLtp..tp....p.E..........................................................................................................t...................................................................	0	3	6	21
+5224	PF05396	Phage_T7_Capsid		Phage T7 capsid assembly protein	Finn RD, Moxon SJ	anon	DOMO:DM08648;	Family	\N	24.00	24.00	24.20	24.20	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.59	0.71	-3.97	6	46	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	41	0	2	42	65	122.10	41	41.72	CHANGED	spLSEtSYtcLttAGYS+uFVDSYI+GQEALV-QYVsuVlcYAGGpEpFsAIhsHLEusNPsAupSL-uAlps+DLATlKAIINLAGtShsKpFG+pPpRSlTpRAhP.ApPsAsp+...EGFuspu	..spLS--SYpcLAcAGYo+uFVDSYI+G.......Q...EA..........LVcpYVpuVh-YAGGcEpFstlhsHh.csp..NPssupuLssAlpspDlATlKAllNLustohscpFG+pspRsloppAhP.Ap..stpp...puFtsp...............................................	0	0	1	2
+5225	PF05397	Med15_fungi	GAL11;	Mediator complex subunit 15	Moxon SJ	anon	DOMO:DM07536;	Family	GAL11 or MED15 is one of the up to 32 or subunits of the Mediator complex which is found from fungi to humans [1]. The Mediator complex interacts with RNA polymerase II and other general transcription factors to form the RNA polymerase II holoenzyme [2], thereby affecting transcription through targetting of activators and repressors [3]. This family is found in fungi and the small metazoan starlet anemone.	21.60	21.60	21.60	22.80	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.33	0.71	-4.11	19	89	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	83	0	62	99	1	114.00	24	9.50	CHANGED	psp.hpp....l+plhpElu+ss.tLpslo..Los-pKstlpppLppspphhupV-sllshhahlopsccss+pLlQMRhhhKc.h....-ts.pGhallsP-hl-Klh.phpKaachh+tpl	..................................sp..chl+plhp-ss+sshphpsls..los-cKstlpppL..ppspphhupl-s.llshhh.hlspsEcsl+pLlQM+hhlpc.h....-....hhhps.hahls.-hlsphh.phpKaaphhhtph..............	0	16	32	54
+5226	PF05398	PufQ		PufQ cytochrome subunit	Moxon SJ	anon	DOMO:DM07133;	Family	This family consists of bacterial PufQ proteins. PufQ id required for bacteriochlorophyll biosynthesis serving a regulatory function in the formation of photosynthetic complexes [1].	22.10	22.10	22.90	22.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.57	0.72	-3.94	11	24	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	24	0	8	20	59	74.20	43	95.60	CHANGED	MoDhTossPhh....+s++sP+..sEFhlYFAlIFlsAlPhAhlsWhhsslRptolsp+GPlARAWspAchITPhIFuA	.MoDhssssPsp....+s++ss+...sEFhlYFAlIhluAlPlAhlsWhhsslRptplsc+GPhA+AWt-ActITPhIFpA.........	0	1	4	6
+5227	PF05399	EVI2A		Ectropic viral integration site 2A protein (EVI2A)	Moxon SJ	anon	DOMO:DM07597;	Family	This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumours [1,2].	25.00	25.00	40.70	40.70	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.63	0.70	-5.10	3	38	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	30	0	21	34	1	200.30	59	94.37	CHANGED	MEHKGH.YLHLAFLMTTVF.SLSsGT+sNYT+LWAsSsouWsSlsQNtT.SRN.PEsNNTNPlTPEVsaKuouTscPpTSsPVPLsSTSspchaTPSuspNSPsTup..tNTSKS+GETFKKEVCEENssNhAMLICLIIIAALFLICTFLFLSTVVLANKVSSLKRSKQVGKRQPRSNGDFLASsGLWPAESDTWKR.sKELTGSNLVMQS..oGVLTAsRERKcEEGTEKLT	..............McppG.p.YLHLAFLhTsla.SLSsGT+uNYTcLWssssosWs..sshQNto.u+s.sps.sTsPhTsp...ss.h+s..suTsh...s...p...o...u...t.....ss.LsspSp..........clhhPs.s.spNSssTsp..htsToKS+uElFKK-lCEENssphAMLICLIIIAVLFLICThLFLSTVVLANKVSSL+RSKQsGKRQPRSNGDFL.ASsGLWPAESDTWKR.sKpLTGssLhMQS..oGsLTAsRERKcEEuTEKLs.................................	0	1	2	7
+5228	PF05400	FliT		Flagellar protein FliT	Moxon SJ	anon	DOMO:DM07567;	Family	This family contains several bacterial flagellar FliT proteins. The  flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium [1].  	22.30	22.30	22.40	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.73	0.72	-3.58	109	993	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	913	12	186	524	21	83.70	30	72.78	CHANGED	hhpsuc.pscW.-plspLtpp.pppll.ptl.t..............tlsts.pppttphlcp....Ilsp-p......plpshhptphscLpptlpptppppphspsY	........................hLphAp.ctpW.-pLlt.Ehs.ahphl.ppltp................................s..sshopsh..pcphpshl+p....IL-N-p......pl+pLlQhRh-cLuphlspuppp+slhsuY................	0	37	94	141
+5229	PF05401	NodS		Nodulation protein S (NodS)	Moxon SJ	anon	DOMO:DM07274;	Family	This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.23	0.71	-4.92	7	251	2012-10-10 17:06:42	2003-04-07 12:59:11	6	6	221	5	103	7241	2646	154.90	30	58.66	CHANGED	opsssapLLpRELAA-DPWRLDuNsFEpcRHsQhLRLSLupGslusALEVGCAAGAFTE+LAPaCpRLTVIDVhPpAIsRsRpRhpc.uHISWlssDVpQFSosEhFDLIVVAEVLYYltDlsphRsAlcNLVpMLAPsGpLVFGSARDAsCpRWGHlAGAETVIuhLsEsLhEVERlcCpGsSssEDCLLu+FppP.uuS	.....................................................................t.hht................s....sDP.W..thp....p....p....h..Y.E....p.....c...+....h...t.......t....h...h.....h.h...s.....L..s...p...t...c....a....p...p....s........h..El...GC..u.s.G....t....L.....o....t...p.....L.........A....t....R.....C........s.......c.......L..........l...s......h....D....l........u.....s......p........A.....l....p......h.........A......+.......p.........R.......l............s.........s..............h.......s.........c.........l......p.......h........h......p........s.........s..........l..............s.......p....................h..........P..........p........t........p.............F........D........L.I...V....l....S....E....l...h....Y....Y...L....s.....s........h....s....c....L......p.....t....h....l.p.....p....h...h.t....t...Ls.ss.G.....p..l....l.......................................................................................................................................thhht...........................................................................	0	19	51	77
+5230	PF05402	PqqD		Coenzyme PQQ synthesis protein D (PqqD)	Moxon SJ	anon	DOMO:DM07172;	Family	This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis [1,2].	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.23	0.72	-3.96	330	1200	2009-01-15 18:05:59	2003-04-07 12:59:11	7	19	972	1	415	1109	164	72.60	20	58.04	CHANGED	s.phllls.ppth................h..............................pLstsushlac.hl.-..u..t.p...o..lpplsptLtpc.a.ssstp....h.ppDltpalppLtp...psllp	...............................................hlll..pthh.......h.......................pLspsushlhphl.-.....G..p..p..o..lspIsp.tLtpc..a..ssstp.......h.t...pDlhpalpplpp.pthl............	0	140	270	343
+5231	PF05403	Plasmodium_HRP		Plasmodium histidine-rich protein (HRPII/III)	Moxon SJ	anon	DOMO:DM07479;	Family	This family consists of several histidine-rich protein II and III sequence from Plasmodium falciparum [1,2].	45.80	45.80	46.30	45.90	45.60	45.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.65	0.70	-13.54	0.70	-4.76	3	1003	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	3	0	3	1004	1	117.00	75	96.41	CHANGED	MVSFSKNKlLSAAVFASVLLLDNNNScFNNNLhSKNAKGLNsNKRLLHEoQA....HssDAHHAHHsADAHH.........AHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAA.AHHAHHAADAHH...AHHAAD...AHHAAD...AHHAAYAHH...AHHAADAHHAAs.........AHHAADAHHAADAHHAAa.......uHpAHHAA......DAHHAsDAH...HtsDAHHsu.........sAHHAADAHHAADAHHAAc	.........................................................................AHH............AHHs..ADAHHAHHsADAHHAHHAADAHH...AHHAADAHH..A...HHAAc...AHH...AHHAAsAHH...AHHAAD...AHHAAc...AHHAA.AHH...AHHAADAHHAss...AHHAss..A...H...H...A...................................................................................................................................................	0	3	3	3
+5232	PF05404	TRAP-delta		Translocon-associated protein, delta subunit precursor (TRAP-delta)	Moxon SJ	anon	Pfam-B_7178 (release 7.7)	Family	This family consists of several eukaryotic translocon-associated protein, delta subunit precursors (TRAP-delta or SSR-delta). The exact function of this protein is unknown [1,2].	25.00	25.00	26.90	26.60	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.86	0.71	-4.80	16	146	2009-09-11 06:46:05	2003-04-07 12:59:11	7	4	109	0	73	146	0	155.00	43	90.57	CHANGED	hhth...hllslsluhsuupsCssPplp.sosYoToDAsIsophsFlsEFoLpCsN.GApsluLaA-Vs.GKlhPVsRssDsu+YQVSWs.EhKpApSGsYpV+haDEEuYuslRKAQRsGEDhsslKPLFTVsVcHpGu.apGPWlsoEllAsllshllhYhAaosKS+l.u	....................hhh.....hhhhhh..hhshss.u.csCtpPp.lo.sShYTToDAsIsocssFIsEhoLpCpN.sspshuLYA-Vs......GK......hPVsRupDs...s+YQ.VSWoh-aKpApuGsYpV+hFDEEuYutlRKAQ.R.ssEDls.slpPLFoVsVcH+.Gs.apGPWVsoElLAAhlulllhYhAFosKoplp.................................	0	28	32	54
+5233	PF05405	Mt_ATP-synt_B		Mitochondrial ATP synthase B chain precursor (ATP-synt_B)	Moxon SJ, Fenech M	anon	Pfam-B_7506 (release 7.7)	Family	The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport. It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L) [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.62	0.71	-4.78	31	515	2012-10-02 21:03:42	2003-04-07 12:59:11	9	8	409	4	214	1035	712	150.90	25	68.55	CHANGED	hhshhhSKclhlhN-EsllshsFluFlhhshKphusshsphhDschcplpsphpps+stphps.lpcpl-ptp.p.p.l.schspsLhpsp+-ssthptcstppptpstlspEl+s+L-ohlphpsshRph.QcclsptlhspVtpplss.sp...hpppsl...ppultplc	.....................hhhhhSpclhlhN-Ehl.s.uh.s.h.lu.h..h..h.h.s.h.K...p.h.G.s..s.h.p...phhDtphpplppphp..phps..sphps..lppph-p.t+..phpth...lph.p.p.h.lh...-...s.pc.......p...s..h.t.h..p...hp...t..t....p...p.....p..t...h...ltpp.lc...t...pLc.hh.l..p.h....ps.p....h........+..pp.Q.c...c...h...sp...h...l....h....t...p....Vt.p.phts..p.........ppphl....tpsls.l....................................................................................	0	74	110	169
+5234	PF05406	WGR		WGR domain	Bateman A	anon	COG3831	Domain	This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Swiss:Q9JN21 and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.02	0.72	-4.02	109	1331	2009-01-15 18:05:59	2003-04-07 12:59:11	10	90	798	5	518	1209	72	76.20	28	11.75	CHANGED	st....hhhphsshs...p..sssKFYtlpl..h......t........hplhtcWGR..........lGss.GQpphc...sFs..s.ppA.hptap+lhpcKp..ppG....a..tp....t.pht	...................ht...........h....s...p...pspKFatlpl.........................s.......hplahpWG+...........................l..Gsp..Gp...s...plc.................sFs..sttpA.hcthtK...lht-Ks..+cG.atp.p....s..........................................	0	180	301	419
+5235	PF05407	Peptidase_C27		Rubella virus endopeptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C27. Required for processing of the rubella virus replication protein.	21.30	21.30	21.40	364.30	20.10	21.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.05	0.71	-4.53	5	69	2012-10-10 12:56:15	2003-04-07 12:59:11	7	2	10	0	0	71	1	166.00	98	11.55	CHANGED	WRCRGWQGMPQVRCTPSNAHAALCRTGVPPRVSTRGGELDPNTCWLRAAANVAQAARACGAYTSAGCPKCAYGRALSEARTHEDFAALSQRWSASHADASPDGTGDPLDPLMETVGCACSRVWVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHF	WRCRGWQGMPQVRCTPSNAHAALCRTGVPPRVSTRGGELDPNTCWLRAAANVAQAARACGAYTSAGCPKCAYGRALSEARTHEDFAALSQRWSASHADASPDGTGDPLDPLMETVGCACSRVWVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHF	0	0	0	0
+5236	PF05408	Peptidase_C28		Foot-and-mouth virus L-proteinase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C28. Protein fold of the peptidase unit for members of this family resembles that of papain. The leader proteinase of foot and mouth disease virus (FMDV) cleaves itself from the growing polyprotein and also cleaves the host translation initiation factor 4GI (eIF4G), thus inhibiting 5'-cap dependent translation.	21.10	21.10	21.10	21.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.28	0.71	-4.82	4	452	2012-10-10 12:56:15	2003-04-07 12:59:11	6	8	73	14	0	458	0	200.20	80	11.04	CHANGED	MsTocsahl...........lhtsF......hch+slF.s+hstphEhT..........uhPNpcsNCWLNuLhQLaphlD.s...........................LF-thYhsPtshTl-sIc.lp-.Ttl.-LpcGuPPhlVla.lppphpsslGTso+PpplClhsGs.hsLuDFaAulhhKs.pHAVFhhsTS-GWhsIDD-chYP.TPcscsVLs...........asPYD.EsLss-apcphtphLR	.......................................MNTTDCFIA...........LlaAl......REIKsLFLoR.sp..GKMEFTLaNGEKKTFYSRPNNHDNCWLNTILQLFRYVDEP...........................FFDWVYpSPENLTL-AI+QLEElTGL...ELHEGGPPALV...IWNIKHL.LaTGIGTASRPSEVCM.VDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPS.DV.L..V...........FVPYDQEPLNGEWKAKVQ++LK.......................	0	0	0	0
+5237	PF05409	Peptidase_C30		Coronavirus  endopeptidase C30	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C30. These peptidases are involved in  viral polyprotein processing in replication.	25.00	25.00	217.90	217.80	20.20	15.60	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.82	0.70	-5.34	5	594	2012-10-02 13:45:52	2003-04-07 12:59:11	8	34	208	139	0	625	0	291.30	52	5.41	CHANGED	GLWLGDpVYCPRHVIASsTohSsIDY-stLSllRLHNFSIsSss.sFLGVVSApM+GulLlLKVsQsNscTPKYoF+oV+PGESFNILACY-GsssGVYGVNMRSNaTIRGSFIsGACGSVGYNLcNGoVcFVYMHQLELGoGsHVGSDL-GsMYGGYEDQPslQlEussshhTsNVVAFLYAAIIN......GssWWLpSooloVEcYNcWAtsNGFTslsuoDAFohLAAKTGVsVE+LLcuIpsLNsGFGGKQILGasSLsDEFTPsEVl+QMaGVNLQSG+V+sh.....spsslhlhuFa	.GLWLsDsVYCPRHVIsosschssssYsclLsphssHsFpVt..s..sN...VpLsVlutpMpGslLhL..pVshuNscTPKYKFsplpPG-oFolLAsYsGsPsGlYtVsMRoNtTIKGSFLsGoCGSVGasl-t.ssVpFsYMHHLELssGsHsGTDLpGcFYGsahDppssQhsssDshhTsNVlAWLYAAl..IN......uspWFlp...ssosol-DFNhWAhsNuaosl....sss..s..s....lshLuAhTGluVpclLsuIpc.L.psGasG+sILGpssLEDEhTPt-VhpQhuGVpLQuphh+hl....hupphhhhh....h............	0	0	0	0
+5238	PF05410	Peptidase_C31		Porcine arterivirus-type cysteine proteinase alpha	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C31. These peptidases are involved in viral polyprotein processing in replication.	25.00	25.00	188.90	186.70	23.90	18.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.45	0.72	-4.17	3	229	2012-10-10 12:56:15	2003-04-07 12:59:11	8	8	11	1	0	264	0	105.00	92	4.26	CHANGED	L+WclPIuaPTVECoPuGsCWLSAIFPIARMTSGNHNFQQRLV+VAuVlYRDGpLTP+HL.+ELQVYERGCRWYPITGPVPGlALaANSlHVSDcPFPGATHVLTN	LRWTLPRAFPTVECSPAGACWLSAIFPIARMTSGNLNFQQRMVRVAAEIYRAGQLTPsVL.KsLQVYERGCRWYPIVGPVPGVuVaANSLHVSDKPFPGATHVLTN.	0	0	0	0
+5239	PF05411	Peptidase_C32		Equine arteritis virus putative proteinase	Studholme DJ	anon	Manual	Family	These proteins are characterised by a region that has been proposed to have peptidase activity involved in viral polyprotein processing in replication.	22.10	22.10	23.10	24.50	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.62	0.71	-4.43	4	221	2012-10-10 12:56:15	2003-04-07 12:59:11	7	9	12	1	0	270	0	127.60	80	4.95	CHANGED	sp+uC..L.t-.ss.-........G+CWhplF.sh.sh.stscEhchAspFGYQTptGVpGKYLtRRLQVpGLRAVsc..sGshlV.shts.pSWIRHlshAsEsV.ssF.clschcllPNsp....P.h.psp+hFRFGs+KaY	..........hQaGC..LPAD.TVPE........GNCWW+LF.DSLPPEVQhKEIRHANQFGYQTKHGVsGKYLQRRLQVNGLRAVTD.ocGPIVIQYFSVKESWIRHLKLsEEPSLPGFEDLLRIRVEPNTS....PLAsKDEKIFRFGSHKWY..............	0	0	0	0
+5240	PF05412	Peptidase_C33		Equine arterivirus Nsp2-type cysteine proteinase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.	25.00	25.00	29.30	39.20	19.90	17.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.63	0.72	-4.24	4	524	2012-10-10 12:56:15	2003-04-07 12:59:11	7	17	14	0	0	536	0	105.90	66	6.01	CHANGED	sYSPPuDGuCGhHCISAIhNchhsssFsTpLsppsRsss-WhSDpDLhQhl.shRLPATl...GtCPSApYhLchsspHWTVThRpG.hAsutLu.ECVpGVC.utEssl	.....YSPPAEGNCGWHCISAIANRMVNSsFETTLPERVRPSDDWATDEDLVNsIQIL.RLPAALDRNGACsSAKYVLKLEGEHWTVSVhPG.MSPoLLPLECVQGCC.EHKGGL....	0	0	0	0
+5241	PF05413	Peptidase_C34		Putative closterovirus papain-like endopeptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C34. Putative closterovirus papain-like  endopeptidase from the apple chlorotic  leaf spot closterovirus.	22.40	22.40	22.40	22.40	21.10	20.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.84	0.72	-3.93	5	13	2012-10-10 12:56:15	2003-04-07 12:59:11	6	2	6	0	0	13	0	92.00	74	4.88	CHANGED	KlKFIKGKaDCLFsSlAclI+KKPEEVMhFlPHlLDRCISNKGCSLDDLRuICpuYEIKVECEGDCGLlElGSlGLPLGRLlLRGNHFoVsS	.....KL+FIKGKFDCLFVSlAEIIHKKPEEVMMFlPHI....hDRClSN.+GCSLDDAKAICEKYEIKIECEGDCGLVECGo.GLSlGRMLLRGNHFoVAS.	0	0	0	0
+5242	PF05414	DUF1717	Peptidase_C35; 	Viral domain of unknown function (DUF1717)	Studholme DJ, Mistry J	anon	Manual	Domain	This domain is found in viral proteins of unknown function.	21.30	21.30	82.20	80.70	19.00	18.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.28	0.72	-3.56	2	9	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	5	0	0	10	0	83.60	67	3.87	CHANGED	sLlphllspD.S--LhssIEp...D+slSpchlE........cVhIhhG.ShlhhsD.hpMtslpht.GhsG+haC............pIKsscst.pS..tp	DLLNFLVNEDIS-ELL-CIEE...DKGLSHEMIE........EVLITKGLSMVYTSDFKEMAVLNRKYGlNGKMYC............TIKGNHCELSS....KE.	1	0	0	0
+5243	PF05415	Peptidase_C36		Beet necrotic yellow vein furovirus-type papain-like endopeptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C36. This protease involved in processing the viral polyprotein.	25.00	25.00	27.40	41.00	20.40	17.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.46	0.72	-4.14	2	8	2012-10-10 12:56:15	2003-04-07 12:59:11	6	2	4	0	0	10	0	103.90	76	4.92	CHANGED	NLlSRPNNCLVVAISECLGVTLEKLDNLMQANssTlsKYHsWLpKKoPSTWpDCRhFADALKVSMaVKVLSDKPYDLsY.VDGAuSslTLaLhGKESDGHFlAA	.NLVSRPNNCLVVAISECLGVTLEKLDNLMQANAVTLDKYHAWLSKKSPSTWQDCRMFADALKVSMYVKVLSDKPYDLTYEVDGAGSSVTLHLlGKESDGHFIAA...	0	0	0	0
+5244	PF05416	Peptidase_C37		Southampton virus-type processing peptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C37. Norwalk-like viruses (NLVs), including the Southampton virus, cause acute non-bacterial gastroenteritis in humans. The NLV genome encodes three open reading frames (ORFs). ORF1 encodes a polyprotein, which is processed by the viral protease into six proteins.	20.20	20.20	20.20	20.60	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	535	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.95	0.70	-6.21	5	408	2012-10-02 13:45:52	2003-04-07 12:59:11	7	5	351	10	0	397	1	490.50	74	30.25	CHANGED	K.DFSHIKLpLAPQGGFD+pGNTPaGKGsMKslTtuuLlARAsALlHERpDEFQLQGs...sYDFDcNRVoAF+pMAADNGlGllcsMRlGs+LKGVTTlEELKsALKsacIusCQIlYpGusYolcSDGKGuVsV-K...l.spssQsssElusAL+RLRsARARsYsSCsQ-llTSIIQlAGoAFVVsRtVKRh.............................chhu+PshGasttVsctutCEo....E-D--saphpspctcsEG.KKGKNKKGRGKK..asAFSoRGLSDEEYDEYKKIREERGGKYSI-EYLpDR-RYEEELAEscAsE-DFs-EpEhcIRQRlFhh+sTRKpRKEERupLGLVTGSDIRKRKPIDWsPsGsLWADD-RpVDYNEKIsFEAPPSIWSRIVpFGSGWGFWVSPoLFIToTHVIPsGspEhFGVPIspIsIH+SGEFs+FRFPKsIRPDVTGMILEEGAPEGTVsSVLIKRsSGELlPLAVRMGTpASMKIQGRlVsGQoGMLLTGANAKuMDLGThPGDCGCPYlYKRGNDWVVhGVHsAATRSGNTVIC	...........s.sDFSHIKLsLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEFELQGPsLTTFNFDRNKVLAFRQLAAENKYGLhDTM+VG+QLKDV+TMPELKQALKsISIKKCQIVYuGsTYTLESDGKGsVKVDR...VQSso...VQTNNELuGALHHLRCARIRYYV+CVQEALYSIIQIAGAAFVTTRIIKRh.....................NIQ.-LWSKPQVEsTEEsTsKDGCPK.....PKD...s..E.EFVIS..SDDIKTEG.KKGKNKsGRGKK..HTAFSSKG..LSDEEYDEYKRIREERNGKYSIEEYLQDRDKYYEEVAIARATEEDFCEEEEAKIRQRIF..RPT..RKQRKEERASLGLVT.GSEIRKRNP-DFKPKGKLWAD...DDRSVDYNEKLSFE.APP.SIWS..RIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPE.GTVsTLLIKRuTGE.LMPLAARMG.THATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAAARGGNTVIC........................................................................................................	0	0	0	0
+5245	PF05417	Peptidase_C41		Hepatitis E cysteine protease	Studholme DJ	anon	Manual	Family	Corresponds to MEROPs family C41. This papain-like protease cleaves the viral polyprotein encoded by ORF1 of the hepatitis E virus (HEV).	27.00	27.00	32.50	39.30	26.70	26.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.97	0.71	-4.69	4	183	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	14	0	0	193	0	150.30	78	9.88	CHANGED	AQCRRWLSAGFHLDPRVLVFDESsPCRCRThlRKsAuKFCCFM+WLGQECTCFLQPAEGlVGDQGHDNEAYEGSDVDPAEsAhhDISGSYlVsGRpLQsLYpALslPuDlsARAuRLTATVcVopssGRL-CcThlGNKTFpToFVDGApLEsNGPEQYsL	.AQCRRWLSAGFHLDPRVLVFDEusPCRCRoFL+KsAtKFCCFMRWLGQ-CTCFLpP.sEGhVG-pGaDNEAaEGS-VDPAE.AplslSGoYhVpGpQLpsLYpALsIPpDlAARAuRLTATVElususGRLpC+TlLGNKTFpTshsDGApLEANGPEQYVL............................	0	0	0	0
+5246	PF05418	Apo-VLDL-II		Apovitellenin I (Apo-VLDL-II)	Moxon SJ	anon	DOMO:DM08067;	Family	This family consists of several avian apovitellenin I sequences. As part of the avian reproductive effort, large quantities of triglyceride-rich very-low-density lipoprotein (VLDL) particles are transported by receptor-mediated endocytosis into the female germ cells. Although the oocytes are surrounded by a layer of granulosa cells harbouring high levels of active lipoprotein lipase, non-lipolysed VLDL is transported into the yolk. This is because VLDL particles from laying chickens are protected from lipolysis by apolipoprotein (apo)-VLDL-II, a potent dimeric lipoprotein lipase inhibitor [1]. Apo-VLDL-II is produced in the liver and secreted into the blood stream when induced by estrogen production in female birds.	20.10	20.10	20.10	59.90	18.70	17.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.87	0.72	-3.80	3	14	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	11	0	5	15	0	75.10	74	79.88	CHANGED	KSIFERD.RRDWLVIPDAVAAYIYEAVNKMSPRAGQFLlDlSQTTVVSGTRNFLIREToKLTILAEQMMEKIKoLWNTKVLGY	KSIFERD.RRDWLVIPDAlAAYIYEoVNKMSPRVGQFLsDsuQTsVVsGTRsFLIRETsKLolLAEQLMEKIKsLWYTKVLGY..	1	0	0	2
+5247	PF05419	GUN4		GUN4-like 	Finn RD	anon	Manual 	Domain	In Arabidopsis, GUN4 is required for the functioning of the plastid mediated repression of nuclear transcription that is involved in controlling the levels of magnesium- protoporphyrin IX.  GUN4 binds the product and substrate of Mg-chelatase, an enzyme that produces Mg-Proto, and activates  Mg-chelatase. GUN4 is thought to participates in plastid-to-nucleus  signaling by regulating magnesium-protoporphyrin IX synthesis or  trafficking.	21.30	21.30	22.60	22.50	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.88	0.71	-4.34	79	375	2012-10-11 20:01:00	2003-04-07 12:59:11	7	23	109	3	134	482	116	131.80	32	38.92	CHANGED	LpphLtspc.......accADcpTtpl..........hlplAsc.....p...pcsalhhs-lpshPspDLpoIDpLWlpYSpG+FGFSVQ+cIa.pul..Gss....................acpFss+lGW.+......ps......sp.....Wh..p....Y.sphs.a.....sls..APpGHLP...............h.hhsthhst.shtt	..................LpphLtptpaccADpcTtpl..........hhplusc................p.......pc..salhh.p-lc..p...h.PspDLpsIDpLWhpaS.pG+..FGFSVQpcIa.ppl..Gsp.............................appFss+l..GW..+..........pp..................sp.......W.h..p......a..sphsa...............sls......AP.pGHLP......sh.h...........th....................................................	0	20	91	130
+5248	PF05420	BCSC_C	BCSC_N; 	Cellulose synthase operon protein C C-terminus (BCSC_C)	Moxon SJ	anon	Pfam-B_10335 (release 8.0)	Family	This family contains the C-terminal regions of several bacterial cellulose synthase operon C (BCSC) proteins. BCSC is involved in cellulose synthesis although the exact function of this protein is unknown [1].	23.10	23.10	23.10	23.80	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.87	0.70	-5.32	29	686	2009-01-15 18:05:59	2003-04-07 12:59:11	6	129	625	0	98	549	12	338.60	55	29.89	CHANGED	hSpLsshpsPlpschPh..hsG+hhh+sssVplsAGohsss...............hspFGsssstsssst........................sQsssGlululGacsc....sapuDIGTTPlG.FphsslVGGlpassclu.s..huaslssuRRslTsSlLSYAGs+DP.................t..........o...GppWGGVspsGsphshoaDtGps.Glau.shuaphlsGcNVpcNpc..hchhsGhYhpllppscpp.lolGlshhhhpYc+N.uhaTaGpGGYaSPQpYhululPlpastRpsp.ao..aclpuSluhpph+pcusshaPtpshhpsth..........................sshasusSssGhu..YslpAtsEYRlusphhlGuslslppupsYs.spuhlYlRYshssh	.........................................................................Y.SDLKAHTTM.LQVD.APa..uDGRhFFRoDhVNMssGoFSTsu...........DGpacssWGTCTLpcCS.Gsc...............................................................................................SQuDoGASVAVGWcN-.......sWp..aDIGTTPM.G.FN..VVDVVGG.lSYScDIG....P...LGYTlNAHRRPISSSLLAFGGQKDu...........................s...........T..GpKWGGVRAsGsGlSLS..YD+GEANGVWA.SLSGDQLoGKNVEDNWR..VRWMTG...YYYKVIN.....pN.N....R.R.V...TlGLNNMIWHYDKDLSGYSLGQGGYYSPQEYLSFAlPVhW.RpRT.EN..WS..WELGuSsSWSHSRs+ThPRYPLhN..LIPsD.app...A...................scQossGG.SSpGFG..YTARALlERRVTuNWFVGsAlDIQQA.KDYsPSHhLLYVRYSAAG.W...........................	0	12	33	68
+5249	PF05421	DUF751		Protein of unknown function (DUF751)	Moxon SJ	anon	Pfam-B_10849 (release 8.0)	Family	This family contains several plant, cyanobacterial and algal proteins of unknown function. The family is exclusively found in phototrophic organisms and may therefore play a role in photosynthesis (personal obs:Moxon SJ).	21.40	21.40	23.00	23.00	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.82	0.72	-3.68	28	118	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	112	0	51	110	86	60.90	38	59.89	CHANGED	FasNVhRYPRYhIohhLGlhhshhpPlhsLh+p.PloulsllhhlluslhhlshsL+AMlsh	.FasNVsRYPRYhIohsLGlhhslhpPlhtLh.Ks.PloAlhlluhllushhhlhhsL+AMlG..........	0	15	36	47
+5250	PF05422	SIN1		Stress-activated map kinase interacting protein 1 (SIN1)	Moxon SJ	anon	Pfam-B_10677 (release 8.0)	Family	This family consists of several stress-activated map kinase interacting protein 1 (MAPKAP1 OR SIN1) sequences. The fission yeast Sty1/Spc1 mitogen-activated protein (MAP) kinase is a member of the eukaryotic stress-activated MAP kinase (SAPK) family. Sin1 interacts with Sty1/Spc1. Cells lacking Sin1 display many, but not all, of the phenotypes of cells lacking the Sty1/Spc1 MAP kinase including sterility, multiple stress sensitivity and a cell-cycle delay. Sin1 is phosphorylated after stress but this is not Sty1/Spc1-dependent [1]. 	19.40	19.40	21.80	21.00	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	523	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.56	0.70	-5.99	4	397	2009-09-11 11:45:00	2003-04-07 12:59:11	7	8	204	2	264	433	0	250.20	17	63.17	CHANGED	+lpoDDs.......GhC-hllls.Dh..................phc+.p.ss.sGGussphptop.................DLu-sp-ss.scsh-I..a.-hsh++.cssohpc.E+Lc..............................hu+psuh+hKs.shp-...phpssE.cphFp+pEl.........................................s.ssKsPhSuhpShLpcpLtcsstQhsN.htEau+FsGpup...sso++IslalPhpss.-...+..PLplplhsoA+lpElIGalhhQYs.pth-s.Lps...slstYsLalsEDDGEl-pDFPPLDsscPluKFGFosLuLVp+hptsssoppcp.hsh..hs+t...I..sN.ch.h+.h..pu.p.pcts.c.pts........hcYh.ptssp..ssl-lcsolpsAtshphshlpcNuuRuc..............................................................c-.p.phhshpDhhpu.happFhl.hhc.htF..+p-hpLuIsG-hlcI......ptSspha.p.KssSIsus.ls.hCclhEcp....Alh+hhh.pNpsoppasFts.uAshst.lss	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	82	134	215
+5251	PF05423	Mycobact_memb		Mycobacterium membrane protein	Moxon SJ	anon	Pfam-B_10885 (release 8.0)	Family	This family contains several membrane proteins from Mycobacterium species.	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.89	0.71	-4.44	7	764	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	115	0	144	501	0	124.40	29	72.34	CHANGED	hlKRhWIPLVIllVVsVuGhoV.RlHuhFGScppsohsss..psscPFNPKpVpYEVFGPsGThAsIsYhDssucPp+lsussLPWShslsTTLsAVhuNlVAQGsusSIGCRIhVsGsVKsERlssplpAaTaClVKSu	...............................................................s.........................................................s............shsP..+.pVsYEVhG..s..s..G..s..hs..s..lsY.h.....D.....s..s.u..ps...pphps....ssLPW..S..hsl..s...s..........s.........s.u....s.s.s...s.l..s..A..p..u...s.....u..s..s...l.sCRIo.V.s......GtVp.s.cp..s....p.t..ts.s.C...........................	0	21	83	126
+5252	PF05424	Duffy_binding		Duffy binding domain	Moxon SJ, Bateman A	anon	Pfam-B_11112 (release 8.0)	Family	This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa [1]. This family is closely associated on PfEMP1 proteins with PFEMP, Pfam:PF03011.	25.50	25.50	25.80	25.50	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.43	0.71	-4.46	409	7405	2012-09-24 07:47:50	2003-04-07 12:59:11	6	68	16	19	63	7892	0	148.80	32	63.35	CHANGED	GACAP.RRh+lCsp.NLE.pl.........s....s.p.......s.........h.........ps.............scsLLscVhh.uAKaEGpslhppa.s......pp.................s...............s......op...............lCTsLARSFADIGDIlRG+Dlapsssp...............pccl-psL+pIF...pcIhcplsst...............hpppYpt.s...s....sa.hpLREDWWssNRcp.............VW+AlTCsus...p.....s.s.p.YFpt..s..s.s...........ss.t.....s..s.....p.....p.cC.........pp..s..s.............s.......p.................sPT...hD....YVPQaLR	................................................................................................................................................................................................................................................................................................................................oh.hDIGDI.l..R....G...+........D......La.....huspt.......................+ccL.-cpL.....Kc.IF.p.p.Iapplppt...................hpt.Yt.s....s.......sa.hpLR..EDWWs.s.N.Rp.p..................VWc.AlTCsst....p....s.t....p...YF.+t.s..ss................tt.......p..s....p...p.pC......ts......t...........................t....p......................sP.T..h.D....YVP.QaLR...........................................................................................	0	56	57	61
+5253	PF05425	CopD		Copper resistance protein D	Finn RD	anon	Pfam-B_19002 (release 8.0)	Family	Copper sequestering activity displayed by some bacteria is determined by copper-binding protein products of the copper resistance operon (cop). CopD, together with CopC, perform copper uptake into the cytoplasm [1].	30.10	30.10	30.10	30.10	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.89	0.72	-3.83	210	1897	2012-10-01 21:57:53	2003-04-07 12:59:11	8	15	1406	0	513	1578	303	102.10	27	27.84	CHANGED	ttshpRF....uphuhhuV...ssll....loGlh.h....hhh.........................h...sshhs..osYG.....hhLhsKluLhlshhslushpRh.....hlhPpl......................tsspsht.tlpphltlEhslulslls...lsusL	.................h..shtRF....SthuhhuV.......ssll....loGlhs.u..hhh......hs.................h...sslhs...osaG......plLLhKhsLlhlhlsluhhs.Rh...............hlh.P+h................................................ttspsst.......h.hht.hs...t.l.E.hslus.llls...lsuh..............................................................	0	124	301	422
+5254	PF05426	Alginate_lyase		Alginate lyase	Moxon SJ, Mistry J, Murzin A	anon	Pfam-B_11800 (release 8.0)	Family	This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyse the depolymerisation of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end [1].  This family adopts an all alpha fold [2].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  --amino -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.78	0.70	-5.04	59	980	2010-01-08 16:30:20	2003-04-07 12:59:11	7	39	535	10	303	910	259	247.60	17	47.74	CHANGED	slss+hth.ssussppDhhuts.ah......sstps............sshshhp+-Gph.........tphtsstpthtphupss.....tsLuhsathstpttastt..ssch.l+sWhlsststhpsplphup.........................h..h..h..pttsshsspp.pthcp.....Whsphhchhhs.t...tupsctstp......NNHuhWhshpVsuhAhhhscpchhchsh.......pp.htpshh.sQls.sDG...shPpEltR.............s+uhpYssasLtslshhAph....upp.tG...DLat....stsutslt+uhcalhsh..st.s.ppa	..................................................................................................................................................................tsht.h.p.stts.....hthuLtahho..s...pp...p..Yupt.......utch.l.......ps..W...hh...s...t..s.t.h.s.s.phphs............................h.t.l.ht...............hh.sh.hh.......psh.ssh.s..s.p..p.hpth.pp............ahp.p....h.hp.......h.hp...........ttpt..htt......................sNa.shhtshthhuhu.lhh....s....cc....s....h.hppul..............................................pt...h....ht...t....t....h..........s.p.....l.......t..............s......G...............pphtR...............................tpshtYsha...sLtshshhuph....utp...s.......Dla......s.psttl.htuhphhh.h..........................................................................................	1	102	191	258
+5255	PF05427	FIBP		Acidic fibroblast growth factor binding (FIBP) 	Finn, RD	anon	Pfam-B_19083 (release 8.0)	Family	Acidic fibroblast growth factor (aFGF) intracellular binding  protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF [1].	20.60	20.60	20.70	22.80	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.27	0.70	-5.22	7	124	2009-09-10 22:14:15	2003-04-07 12:59:11	6	4	87	0	83	127	1	291.70	43	86.60	CHANGED	ss-lDVFluNhTllD.ElYQLWl-GYoso-AVslhhppGhlcphGssuDlltSDshDHYRTaphlE+hLHtPsKLhpQ.hF.QlsPpppuhLIE+YYuhD-uhsREllGKKLSpts+KDLD-lupKTGlpLKSCRRQFDNhKRlFKsVEEh.GsLspNI+QpFlLs-cLAccYAAlVFhAs.RFETsK+KLQYLoFpDFhhCuptlhppWThsh.csts-..hDh-hDKEFL.DL+El+hLlsccc.l...KpLVshpL+sphh..sapEh-uNF+oh.RullsIAssLp+s+-lRshFlDLsEKhIEPh+tssWspppVphFhsphTpSVhsL-s.Rc....psLW-RYMtslpsCLh+MYHs	.........................................................h.s-lDlFluNhTllD.-l..YpLWl-GaSss-AVsh.hhp.....pG....h..h..pp..........h.....s.Ast...s.....lltSDshDHYRTFphl.E.+hLcsPsKLh..p.QhhF.QlsPpppthLIE+YYshD-shsRElLGKKLSptp+KD.........LD-lupK........TslpLKSCRRQFDNhKRlFKsV.E-....h................G..........s..LspNI.ppcFlLSc..cLA+cYAslVFhAs.RFET..sK+..K..LQYLoFtDhhhCup.hhp.WThsh.....................p...-......hDh-hD+-FL.-L+-L+.h.Ll...sccc.l...hKpLVshtL+s......h..l........shp-h-sN.F+.sh.RullslAspLp+s+-lRshFl....DLsE+hl-PhRpstWshpplphFLsthst.....s.s..hpl..-h..+c..............psh....Wc....RYMtsl.p.Cl.phYc......................................................	0	38	49	66
+5256	PF05428	CRF-BP		Corticotropin-releasing factor binding protein (CRF-BP)	Moxon SJ	anon	Pfam-B_11928 (release 8.0)	Family	This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development [1].	25.00	25.00	25.30	25.20	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.95	0.70	-5.59	7	97	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	73	0	52	94	0	264.40	44	90.03	CHANGED	Mpsuucs.................phthl.L.lsshtupsRh.t.pssustshhhLhsuslpRE.p.-..a...hcChshhuh.G.aha.ust.t.sCuhalIuEPDpllpIchcpsslsCpsGshl...........................................................tlhDGW.LpGEhFPuppDH.LPh.cRhs-aCss......hss++hhRSSQNsAhl.aRl.s.GsuFohsVRhh.NshPCNllsQsspGhFTMss.tQtRNCSh.SllaPsslclssLplGt...pslthp..s.hsCtssGDhVElhGusGLDsupMhshuslChshss....sp.pIhCssosVRhVSoGpa.Npssh.hRphD..-h-hsp	..............................................................................................................t.p......t..aph.hcC.hphhuh.G..Fhahu.p.....ps.phhCuhahIuEP-phIplchc.lslsCps.Gshl...........................................................p.lhDGW.LpGEhFPSspDHsLPhp-RYhDaCss.................s.s++shRSSQNVAMlhFRltpsGsuFolol+p..N.hPCNllSQ..ossGtaThssstQ+RNCSa.SllYPsslplucLslGph............ps.lp..h...p....c......s.....hsCt..t...u..DaVElhGusGlDso.pMh.huslChshpss...sp.plsCssosVRhVSSG+a.NplohphR.l-..-lp...p............	0	10	15	33
+5258	PF05430	Methyltransf_30	DUF752;	S-adenosyl-L-methionine-dependent methyltransferase	Moxon SJ, Eberhardt R	anon	Pfam-B_12088 (release 8.0)	Family	This family is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. It is often found in association with Pfam:PF01266, where it is responsible for catalysing the transfer of a methyl group from S-adenosyl-L-methionine to 5-aminomethyl-2-thiouridine to form 5-methylaminomethyl-2-thiouridine [1,2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.20	0.71	-4.45	17	1653	2012-10-10 17:06:42	2003-04-07 12:59:11	6	6	1635	15	373	1468	553	123.70	41	22.62	CHANGED	schtphtctLhppash...h.Ghhclths.stssLcLhhGDs.pptlspls....tpsDAWFLDGFuPs+NP-MWs.plhptluchscssGshuTaouAuhVR+uLhpAGFp.lp+p.GFGpKREhlpushs	........................................................pht.huppL.tpa....Phs.......hsG.....h.....a.Rl..hhs......t...scl.....sL.....-LhaG..D.h.pc.h..l.spLs....................tplDAWFLD......G.FAP....u.K...N..P...-.....MWops.....LFsthA....+L.u.+...s.....G..u...TlA..TFTu......A..G..h.....VR..RuLppAGFs.h.p.K.....t.+.GF.G.pKREMLpGhh.....................................	0	84	217	310
+5259	PF05431	Toxin_10	Toxin_P42; 	Insecticidal Crystal Toxin, P42 	Finn RD	anon	Pfam-B_19338 (release 8.0)	Family	Family of Bacillus insecticidal crystal toxins.  Strains of Bacillus that have this insecticidal activity use a binary toxin comprised of two proteins, P51 and P42 (this family).  Members of this family are highly conserved  between strains of different serotypes and phage groups [1].	28.60	28.60	28.70	32.90	27.80	28.10	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.40	0.71	-4.67	7	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	11	0	3	42	0	196.30	38	50.73	CHANGED	PphPp.sopLpshPcho...sIs.sGs.Pp.....lhG.TLIPCIhVsD.sI.shssphKpoPYYlLc+hQYWpphhuu..hlsstp+pohp.chGhspsppsohlsslshpIssD...thpF.....GstTssh+pQlsppLph.hSpssp.htchpcph-hsNsp.stshphstFlhtppapLhRhNGo.lps..hhshDpchhslpoYPs	......................PphPp..sppL.shPcho...sID..Gh.Ppps.pslhGtTLlPCIMV.sDssl....sp...ss+hKsoPYYllc+ppYW..pphhuu..lls....stpccohs.csGlscssQsoMhsslshpIGuD..hGh+F............GstTpsIKsQloc-LphphSpoop.htcpsEppEhsNss.shshpasuallsocapLpRssGoplps..hhshDpchhsltoYPp.............	0	2	2	3
+5260	PF05432	BSP_II		Bone sialoprotein II (BSP-II)	Moxon SJ	anon	Pfam-B_12103 (release 8.0)	Family	Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts [1]. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone [2]. 	25.00	25.00	25.00	40.00	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.25	0.70	-5.13	4	53	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	33	0	23	49	0	263.80	57	94.51	CHANGED	FSMKNapRRAKhEDSEENGVFKYRPRYYLYKHAYFYPsLKRFsVQuuSDSSEENGsGDSSEEEtEEE.sSNEEtN...NE-S-uNEDE-uEAENhTLSosThGYGu-sTsGTusIGLAAlpLP+KAGshtpKusKc-ESDE-EEEEE...EpEEpEAEV--NEQusNGTSTNST.EVssGNGoSGG....DNGEE.GEEESVTEAtsEGTTVA.......u.TTss..sGhpsTTP.pElhGTTsPPhuKsTTst..GEYEQT.GspEY-ssYEIY-uENGEP.RGDsYRAYEDEYSYYKGRGY-uYsGQDYY	.........................FShKNhHRRsKlEDSEENGVFK..aRPRYYLYKHA.YFYPPLKRFsVQsu.SDSSEEsGDGs.S.pEEEtE.EE..TSNE.cEN.....NE-...Spt..NE..DE-..uEu..ENoTLSs...oT.uY.Gt.-sTsGsG.hGL.A.Al......plPKKu.Gt..htpK.us+p.cESD.E......-..EEEEE.....tENEcpEAE.VDENEQGlNGTSTNST.Es..-sGNGuuGG.........DsGEE..tEE.ESVTEAssEuT..Tss.......scTTssssuGapsTTPsp.ts...YtTTsP..PhtcsTTstYts.EYEpT...GsNEYDsGYEl.....Y-.sENGEP.RGDsYRAYEDEYS..Y...YKG+GYDuY-GQDYY...........	0	1	2	5
+5261	PF05433	Rick_17kDa_Anti		Glycine zipper 2TM domain	Moxon SJ, Bateman A	anon	Pfam-B_13382 (Rel 8.0) & Pfam-B_6 (Rel 24.0)	Family	This family includes a putative two transmembrane alpha-helical region that contains glycine zipper motifs [2]. This family includes  several Rickettsia genus specific 17 kDa surface antigen proteins [1].	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  --amino -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-9.09	0.72	-4.29	174	3882	2012-10-03 03:18:43	2003-04-07 12:59:11	10	13	1511	0	736	2475	469	41.70	44	28.29	CHANGED	hGshhGAssGulhGstl.ut......psthhusll.GAssGuhlGstlu	..............GsllGAlsGGllGspl.Gu.......GsGp.s..l.uTlu.GAlsGGlsGpplt...................	0	114	335	536
+5262	PF05434	Tmemb_9	TMEM9; 	TMEM9	Moxon SJ	anon	Pfam-B_12447 (release 8.0)	Family	This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9 Swiss:Q9P0T7. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localised to the late endosomes and lysosomes [1]. Members of this family contain Pfam:PF03128 repeats in their N-terminal region.	24.80	24.80	25.50	24.90	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.93	0.71	-4.46	6	196	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	89	0	107	165	0	131.20	46	75.14	CHANGED	PY+chsG+Iapp.........NVo.KDCNCLHVV-P...hPV.G+DVEAYCLcCECKYEERSooTIKVsIIIYLSllGhLLLYMlFLhllDPLL.RKhssao..lpo-E-s-DspPhssAtsslstuRucsNVLNRVEaAQpRWK+QVQEQRKoVFDRHshL	.......................................uplY.pp.........Nl.o..pc-......C...............sChcVV.cP....M.PV..GtD...lEAYCLhCECKYEERSosTIKVslIIaLollGhLLLYMlaLhLl-Pll...R+........sh.s.p.l..ps--...........-...........s..........tDt..ps.hss...............u...t....s........s..........sts...tu..ssVLp+V-htQpRWKhQVpEQR+slFDRHhhL...........................................	0	27	36	67
+5263	PF05435	Phi-29_GP3		Phi-29 DNA terminal protein GP3	Moxon SJ	anon	Pfam-B_14111 (release 8.0)	Family	This family consists of DNA terminal protein GP3 sequences from Phi-29 like bacteriophages. DNA terminal protein GP3 is linked to the 5' ends of both strands of the genome through a phosphodiester bond between the beta-hydroxyl group of a serine residue and the 5'-phosphate of the terminal deoxyadenylate. This protein is essential for DNA replication and is involved in the priming of DNA elongation [1].	25.00	25.00	449.40	449.30	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.70	0.70	-5.18	3	7	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	6	0	8	0	265.90	66	100.00	CHANGED	MARsSRIRITcNDKAEYAKLVKNTKAKIoRTKKKYGlDLSuEIslPsLESFcTREQFNKWKc+AESFTNRANpcYQFVKNcYGVVASKAKIsEIt+NTKEAQRlVDEpl-chcDKEaISGGKsQG.TVGQRhplLSPucVTGIuRPcDFDFsKVRTYuRLRTLEEuMccRosPsYYE++MpQLQpNFI+.SVEGSFNS..tADELVE+LKKIPPDDFYELFLhasEISFEpFDSEGssVEASEuhLpKI+SYL-cYcRGDsDLSLKGF	MARssRIRIpsNDKA.YA+LVKNTKAKIuRTKKKYGlDLosEI-lPsL-SFpTRtpFNKWKcptpSFTNRAN.pYQF.KNtYGlVASKAKIsEIt+NTKEsQRlVDEphcthcDK.ahuGGK.QG.TltQRhthhSPupVTGIsRPpDFsFscVRSYuRLRTLEEuMt.+ssPpYY-++MhQhp.NFIc..VEtSFNS..huDELlEcLKKIPPDDFaELaLhhsEISFE.FDSEGpsVEssEu.l.KIhSYL-pYcRGDhsLsLKGF	0	0	0	0
+5264	PF05436	MF_alpha_N		Mating factor alpha precursor N-terminus	Moxon SJ	anon	Pfam-B_12643 (release 8.0)	Family	This family contains the N-terminal regions of the Saccharomyces mating factor alpha precursor protein. All proteins in this family contain one or more copies Pfam:PF04648 further toward their C terminus.	21.90	21.90	25.30	25.50	20.00	18.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.85	0.72	-4.30	4	57	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	33	0	25	50	0	85.40	49	57.30	CHANGED	MKF.ohhoAsllAAsShsAs..ts.o---ou.pIPAEAlIGYLDLtGDhDIAVlPFSNuTssGLLFlNTTIsshApKEpussLsKRE	.........M+Fs.Slhos.hhhAAs.S.shAu..s.....t..spo--..-tA.....plPAEAlIGYLDLtGDpDlAlLPF..SNuTssGLLFlNTTIAptA....tc.E...ps...s.oLsKRE..............	0	2	12	20
+5265	PF05437	AzlD		Branched-chain amino acid transport protein (AzlD)	Moxon SJ	anon	Pfam-B_14345 (release 8.0)	Family	This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain [1].	22.70	22.70	22.70	22.90	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.19	0.72	-4.06	189	3465	2009-09-11 13:40:13	2003-04-07 12:59:11	7	2	2847	0	681	2161	1469	96.30	21	90.16	CHANGED	hhlhIlshulsTalsRhlshhlhtp.hplsshlp...phLphlPs....ulLsALlssslh.....hsttth......ssspll...Aslsshllshhp+.s....hlhollsGhsshhllp	......................hlhllhh.u.l...sTalhRhlPhhlhpp...h....t....h.s....s......hht...........thLphlPh.......ullsulhhsslh.............hst.t.t.................thspll..uhhsss.hlth.h..p+.s....ll.lsllsGhlshhll...................	0	196	408	553
+5266	PF05438	TRH		Thyrotropin-releasing hormone (TRH)	Moxon SJ	anon	Pfam-B_14384 (release 8.0)	Family	This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localised on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH [1]. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans [2].	27.80	27.80	27.80	28.40	25.30	27.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.17	0.70	-4.94	9	77	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	52	0	28	66	0	185.50	44	86.80	CHANGED	shlllLhuL.....sVstu.u....hQtpshsucspsuhD..-lLp+AEp.LLLRShLpphp--pst..ss....Qs-WlpKRQHPGKR.pc-.......................cKRQHPG+R--p........................tp.ts.hsp.+RQHPGKR..ht.....h.-pP...hhhS-loKRQHPG+Ral.....KRQHPG+RphcEEst..............lEKRQHPGKRh...........t.C-shsssGC..uul.L	..................hhl.lhhulh.s.hslstups....h.tps.httpt...-...lLppsct.lhLpp.lpphptcptt...st......t.pWlsKRQHPGKR.p--...................cKRQHPG+R--p.......................................s.s..htst.ss.pKRQHPG+R............sP....hLt.sloKRQHPGRRhlss...KtQ+shccct...--Epc..tthhs................EKRQHPGKRhh.........ssPCss.sssup..sth..............	0	4	6	13
+5267	PF05439	JTB		Jumping translocation breakpoint protein (JTB)	Moxon SJ	anon	Pfam-B_14502 (release 8.0)	Family	This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the trans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex) [1]. JTB has also been implicated in prostatic carcinomas [2].	20.90	20.90	21.00	20.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.77	0.71	-4.30	4	94	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	76	1	60	88	0	108.80	36	67.73	CHANGED	A-uPs+cEKlssppsspsCWhsEcFsVspECuPCSsFcI..Kohs..cChpTGYhE+lsCSsScps.hRSC.RSALh.Ep+.FaKFEsssssluLl.hhlshhRpRQL-R+sh.+lc+Ql	...................................h.p..ss..tsCWhh.EcasVspECpPCosFph..+ohs...tCspT.GYhEplpCs..sSc...p....h+S......C.Rsuhh.Ep+hFWKFEusshslull.shlVhhRpR.L-R+shp+lc+Ql......................	0	22	28	45
+5269	PF05440	MtrB		Tetrahydromethanopterin S-methyltransferase subunit B	Moxon SJ	anon	Pfam-B_15021 (release 8.0)	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of  Methanosarcina mazei Go1 is a membrane-associated, corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1]. 	19.40	19.40	19.40	54.20	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.26	0.72	-3.95	5	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	53	0	38	51	5	96.10	35	92.20	CHANGED	olV+IAPElsLVMDs-TGsVuctp.cDlIhlSM-PlaE+l-KLEulADDLlNSLDPSpPsLNSaPGREGVahhAGhaoNuFYGFllGLuIsuLLALIL	.........hVplsPEhsLVhDspoGlluptt.c-llhlohsPl.-plscL-phAD-LhNSLDPcss.lpSaPGREGshhhAGhhoshaaGFhlGLhl.hsLlshh.h.......	1	8	24	32
+5271	PF05443	ROS_MUCR		ROS/MUCR transcriptional regulator protein	Moxon SJ	anon	Pfam-B_1733 (release 8.0)	Family	This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid [1] and is necessary for succinoglycan production [2]. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan [3].	23.80	23.80	24.50	24.60	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.56	0.71	-4.38	127	729	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	320	1	355	661	38	123.90	40	78.76	CHANGED	tsstsllcLTA-IVuAYVS..sNslsss-LPsLIpsVasuLs..............slss...ss....t..ts.....p..................c.pP.AV......s..l+KSl.pPDhllCLEDGK.taKoL.KRHLpocaulTP-pYRpKWGLPsDYPMVAPsYAtpRSpLAKphGLGp	..........................................................s....thlpLsu-IVuAaVu..s..Nslsss-LPsLItpVasuLt......................................plstst.........t..........p.............................................................................p.pP.AV.....s.l+KSl.psDhIlCLEDGK.paKoL.KRHLto+ashT.P-pYRpKWGLP.s-YPMVAPsYAtpRScLAKphGLGp.......................................	0	93	242	268
+5272	PF05444	DUF753		Protein of unknown function (DUF753)	Moxon SJ	anon	Pfam-B_1957 (release 8.0)	Family	This family contains sequences with are repeated in several uncharacterised proteins from Drosophila melanogaster.	21.00	21.00	21.20	21.20	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.89	0.71	-12.93	0.71	-4.33	80	560	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	25	0	372	539	0	130.60	24	85.02	CHANGED	hpCsosp.s.ssC...tssshst.sppCpst.t......C.hotl........ssss.......htRGChscht........pssCsss.ts.....CpsC.su..s.sCNs.t.hstsR.hpCapCs....sssC....tssss.psphC.ha.....pts-p...Casph....ssshspRGChosh...............ppt..ssssppChh..Csss	............................h..Cpspp..s.sp..C.....ss.sh.hppCpst.t.......C.hohh..........ps.st............htRGChssl.t..t......tttCsss......t...sC.ttC...su....s.....tCNs..t.h.......stsp..hpChpCs......sssC.......ss....tst.C.hh.....t.tpt...Chh.h.....ts..h.hGC.sp..................................s.....................	0	48	79	267
+5273	PF05445	Pox_ser-thr_kin		Poxvirus serine/threonine protein kinase	Moxon SJ	anon	Pfam-B_1974 (release 8.0)	Family	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.67	0.70	-5.69	9	74	2012-10-02 22:05:25	2003-04-07 12:59:11	6	1	50	0	0	102	4	427.40	67	96.40	CHANGED	ssh-tpa..hpspcps-TslLG.......DsIYFcalhSQlDhppsWu.Psl+ll+YF+s.Fs+psls+Iscp-YlNPSaFQ.KDcRFYPhNDDFYHlSTGGYGIVF+h.DcYVVKFVaEP.sppapPh-sTuEaTIP+FLYNNLKG...DE+cLlVCAhAMGlNYKlsFLasLY+RVLahLLLlhpIhDsp.Lsl.....paS++hhLKhFs-.+Kss.cFVKLlSYFYPhVlpSNlNVI..N.FsahhaF.......FEHEKRusYhY-RGNIIIFPLA+CSA-Klo.phstchGFt...........SlscYlKFlFLQluLLYIKIYELPsCsNFlHlDLKPDNILlFDS..pcslpIphsspsaVFcE.l+ssLNDFDFSQVusIh.NKKIKsSl+lE.pNWYYDFHF....FsHTLh+sYPEIp.pD.tFspuLpEahh..CpsKsTC-KFRL+VShLHPISFLtcFlt+s.lFSsWIN	............................................................................sss...EaQW..hSscchsDTVILG.......DslYFs.IhSQLDl+QsWA.PsVRLLpYFKN.FN+ETL.KIp-s-YINsSFFQQKDKRFYPlN.DDFYHISTGGYGIVFKI.DpYVVKFVFEs.sKhYS..PMETTAEaTVPKFLYNNLKG...DEKKLIVCAhAMGLNYKLTFLHoLYKRVLaMLLLLIQTMDGQcLSL.....+aSpKsFLKuFNE.RKDSIKFVKLLSaFYPuVIpSNINVI..NY..Fs+MFHF.......FEHEKRoNYp.Y-RGNIIIFPLAhaSA.DKVssEh..Al+LGFK................SLVpYIKFIFLQMALLYIKIYELPCCcNFLHsDLKPDNILLFDS...sEPIh.I.+lpc.ppFVFN...E.IKu.ALNDFD.....FSQVA.........uIl.NKKI.K.N......shKVE.HNWYYDFHF....FlHTLL..KTYPEIE.+DhEFosALEEFIM....C.oKosCDKaRLKVSILHPISFLE..KFIhRD.IFScWIN...................................................	1	0	0	0
+5276	PF05448	AXE1		Acetyl xylan esterase (AXE1)	Moxon SJ	anon	Pfam-B_4814 (release 8.0)	Family	This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.90	0.70	-5.94	11	1046	2012-10-03 11:45:05	2003-04-07 12:59:11	7	10	743	111	195	2479	716	275.50	29	81.06	CHANGED	MtlhDhsLp-LppY+upsstPcDFs-FWspsLcEhpplsschcLppsDaplstVcsY-LTFsGhsGu+IcuhhlhP+.sctphPsllcFHGYsus.sG-hp-hLpasusGaushuMDsRGQG.....GtSpD.sssssussh.GahhRGlh-..t-phaYRcVFLDssphl-llhShspVDccRluVhGuSQGGuLALAsAALss+.lKtlls.YPFLSDFcRsh-lsh.pcsYpEltpYF+.hssp+E+EpclFpTLuYhDlhNLAcRlKusVLhulGLhDplCPPST.FAAYN+lpsc.K-lclYs.auHEshssa.p-phhpaLpcl	.............................................................................................................................htst....Pt.D.F-tFWpt.phpph...............p.....t..h........p......h...p..h..p.....h.....-..h....t....h...s........t.l..cs.a......c...l....s..a..p..u......h................t........s......s......p......lhuhl...h.h....P........c....................s.....p......t...t.........h......P..h...l.l....p........a..h...G............Y......h..s.................p.....t......h...................h....p.........h........l..............t..........a..........s....s..........t.....G.....a...u.s.lshDs......R..G..Qu..........................sho...pD......ts.........s...s..s....h.t......G...a..h.....h.......c...G....h....s..............-..p.h...a....a......+....c....l....a.........h......D.h.h.p....hl.-.h.l.t.s.h..s...p.....l...D...t.p......+........lushGs.SQG.G.ul.u...l.s.....s...u......u..........L..........s....s..........c.....l...pt......s...hs......h..P.....h...L......s...c....h..p..c.s...h.p....h..s.s........tt.s...Y....p..l..h...p...ah..p........s.....h.....p..t..p........t..phh.t.s..L..u.Yh.Ds..hph..A..p..+l.....p...s...s..h..h..sGh.DplC.......P.....o...aA....hYNtl.............s...s..............t......K...p...hh..l.h......huHtshtsh.....t.h......t....................................................................................................................	1	79	144	172
+5277	PF05449	DUF754		Protein of unknown function (DUF754)	Yeats C	anon	Yeats C	Domain	This domain appears to be found in a group of  prophage proteins.	25.00	25.00	27.70	29.70	23.30	21.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.71	0.72	-3.96	13	238	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	203	0	35	191	1	82.60	35	88.67	CHANGED	llsAllCusIslRL.lsY.RRsGARHRhhsShlAYlLslssGstslpllhu.....phtssuhhcshltslLslhVhpARGNVA+ll+ss	...........hlNshlCssIslpL.hhY.RR.s.suRHRshhSaLAalLhlshussPlphlhG.....ph.sssahtlhlNllhsshVlpARGNVu+lhc..t...	0	3	9	20
+5278	PF05450	Nicastrin		Nicastrin	Moxon SJ	anon	Pfam-B_15452 (release 8.0)	Family	Nicastrin and presenilin are two major components of the gamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch.  Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin) [1]. A region featured in this family has a fold similar to human transferrin receptor (TfR, Swiss:P02786) and a bacterial aminopeptidase (Swiss:P80561). It is implicated in the pathogenesis of Alzheimer's disease [4].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.59	0.70	-5.12	6	234	2012-10-02 19:46:12	2003-04-07 12:59:11	10	9	139	0	136	395	62	196.70	31	32.33	CHANGED	+lllVosRhDosohFcslulGA.SslsuhlslLuAAcuL....p+h.ss.Ss.p+NVlFlhFNGEoaDYIGSpRFlY-h-pGpFP.........stsIu.ssIDhhLElGsluptpu.t...hahH....utpspolsspsh-hLpphpcShuuss.tlh.sssssstlPPoShpSFLRcssshsuVlLssasspa.N+aYHSIhDcs-Nls.......................ps....s..thplsssAollAtuLY	.........................hlhsssphD..otoh.......F...........s.....l.....u.s..GAposluuhlshLusAcsL............pch......s...s.h.....s...p.h.........+...slhFs.hFpGE.sa......s.YlGSp....RhlaD...h.cp..s.phs........................................l....p.......h.......csI-...t....hlEls...pluht.ss.t........lahHss....s.t.ps...ps..h....tspl.ch...l......ssl.........ppu..h..shs.....s.h.hhh.......t...s...s...................lPP.o.S.hppFL+......t....p...........s......hs..u....ll.l.ssa..t.t.t.a..N.p.a.YpShhDs.p.tlt................................................................................................................................................................	2	50	74	112
+5279	PF05451	Phytoreo_Pns		Phytoreovirus nonstructural protein Pns10/11	Moxon SJ	anon	Pfam-B_15695 (release 8.0)	Family	This family consists of Phytoreovirus nonstructural proteins Pns10 and Pns11. Genome segment S11 of rice gall dwarf virus (RGDV), a member of Phytoreovirus encodes a putative protein of 40 kDa that exhibits approximately 37% homology at the amino acid level to the nonstructural proteins Pns10 of rice dwarf and wound tumour viruses, which are other members of Phytoreovirus [1].	19.70	19.70	20.00	20.40	19.50	18.10	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.08	0.70	-5.79	4	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	1	17	0	330.40	43	93.21	CHANGED	MDssT-phlpLHh-llspcpGapIlpKaDAI+KLpL....stcuspsNISpAAhsplppaupppEAYlASDLs-R-l.ssshhKAlIFVPtSVlssGK..KDLlPYGVlssslIaVPETholLDslp.hlsp...++PlSshllhchh+slph-VlGSsYDoaYYCssScYGKNLIKhusshPs.PpplRLSlsDLshsAhppsHshssphl.phhs+hPsGFpPKsHlL+I.hssh-MEhhcphVpp.huccP.stFpYsDppNlLpRTThFSsscsFSahILWRGW.STYKEhLSQDQlopFhtt.GsuGshssahhTaPShF-EGslYlpYcah...TP....put+uts.hPshsph	............MDs-TpRllpLHs-llppcpGapIloKaDAI+Kl+L....sssussNNlSpAALsKLpcaAspuEAYlsSDLs-Rsl.ssslhKAlIFss+SVlosGK.lKDllPYGVhsusllalPETholLDsI..hlupp..++PhohsllhphsKslph-llGssYDoaYYCsuStYGKNLl+husthPshPsplRLSlGDLsYhAApShHshAspYl.+lFs+LPsGFoP+SHLh+I.hslL-M-pFKchVpphhA+ps.stFpY-DsKNlLpRsshFSsDHpYotlILWRGWuSTYtEhLSQ-QlophpupsGhAGDLGhaphTlsShF-EGtVYlpY+Fh...TPt........ptsSt+utslYPsL.th........	2	0	1	1
+5280	PF05452	Clavanin		Clavanin	Moxon SJ	anon	Pfam-B_15887 (release 8.0)	Family	This family consists of clavanin proteins from the haemocytes of the invertebrate Styela clava, a solitary tunicate. The family is made up of four alpha-helical antimicrobial peptides, clavanins A, B, C and D. The tunicate peptides resemble magainins in size, primary sequence and antibacterial activity. Synthetic clavanin A displays comparable antimicrobial activity to magainins and cecropins. The presence of alpha-helical antimicrobial peptides in the haemocytes of a urochordate suggests that such peptides are primeval effectors of innate immunity in the vertebrate lineage [1].	20.90	20.90	21.20	28.70	20.70	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.81	0.72	-3.99	2	6	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1	0	0	7	0	70.50	82	100.00	CHANGED	MKThILILLILGLGIsAKSLEEpKu-EEKhh+hlGplIHtlGphVathuhshGDDQQDNGKFYGaYAEDNGKHWYDTGDQ	MKTTILILLILGLGINAKSLEERKSEEEKlF+hLG+IIHHVGNFVHGFSHVFGDDQQDNGKFYGaYAEDNGKHWYDTGDQ	0	0	0	0
+5281	PF05453	Toxin_6	toxin_6; 	BmTXKS1/BmP02 toxin family	Moxon SJ, Lee SC	anon	Pfam-B_16009 (release 8.0)	Family	This family consists of toxin-like peptides that are isolated from the venom of Buthus martensii Karsch scorpion. The precursor consists of 60 amino acid residues, with a putative signal peptide of 28 residues and an extra residue, and a mature peptide of 31 residues with an amidated C-terminal. The peptides share close homology with other scorpion K+ channel toxins and should present a common three-dimensional fold - the Cysteine -Stabilised alphabeta (CSalphabeta) motif [3]. This family acts by blocking small conductance calcium activated potassium ion channels in their victim [1,2].	25.00	25.00	41.20	40.90	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.59	0.72	-3.71	5	25	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	10	5	0	30	0	28.00	61	66.19	CHANGED	VGCEECPhHCKGKpAKPTC-Nu..VCsCNl	..VuCE-CP.HCpsKsA+spCDNs..hCsCps.	0	0	0	0
+5282	PF05454	DAG1		Dystroglycan (Dystrophin-associated glycoprotein 1)	Moxon SJ	anon	Pfam-B_15784 (release 8.0)	Family	Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and  [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear [1]. 	22.00	22.00	22.10	22.00	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.91	0.70	-5.23	4	207	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	101	1	85	198	0	192.60	39	30.30	CHANGED	shF+AhFsGDtptVhNDIpKKIhLVKKLAhuFGDRNoSoITL+sIT....+GSllV-WTNNTL...ppPCPc-Qlttlu++Ih-s-GpPRptFppulEP-a+hoNIoVssouSC+H..hpaIPh...c.IPotssss.sP-csscKSSpDDVYLHTVIPAVVVAAILLIAGIIAMICYR..KKRKGKLTl...EDQATFIKKGVPIIFADELDDSKPPPSSSMPLILpEEKsPLPPPEYPNpssPEThPLNQD.hGEYTPL+DEDPNAPPYQPPPPFosPMEGKGSRPKNMTPYRSPPPYVPP	.......................s..Fphhhthc..t...h...s.D..lpKKhhLV++LA.huaGDpssooITlpsI..o......pGoh..lVt..a.Nsol.......hp..Cs.cptlt.hht.ph.l.h.p..p.p....h.p.....p.th....p...s...h..tsp.a.hhphshh..upCpp.....h..s.......h..s....................s.tp....hh.l..slllhhhhl.l.ss.Ihhhhhp......h++pGK........................................................................................................................................................................................................	0	29	36	64
+5283	PF05455	GvpH		GvpH	Moxon SJ	anon	Pfam-B_16017 (release 8.0)	Family	This family consists of archaeal GvpH proteins which are thought to be involved in gas vesicle synthesis [1].	22.00	22.00	22.00	22.00	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.05	0.71	-4.64	4	26	2012-10-02 21:54:05	2003-04-07 12:59:11	6	1	22	0	14	71	7	161.80	22	91.78	CHANGED	.ssDDp........SDp.S...GLLDQLcsLlEsLAEIE.pEsG+ppspGpIDRGsARIDYDY-VSIGLGscuRsspss-tPss-sscsE.......phEpohHlETRssDDG.-lVVlADLPGVsD-c.lDVsL-sDpsALpl+scDcVVcRlsLDcPsspITshplpNQVLEIRLstos-opG.u-ss	...............................................................................s......................thhptlttllphLs.pl.t.pc.t......tp....hp..tpu..th....s....p..t...p.hphs....YsaslphG...lssc.....s...c........t...tt..t.s.hsp.t.csc..............p..tp.shc......l-...s+t.......p-Du.-ll.VlADLPGVsc...-c.lcVsl-s-pssLsl..p...s...s...c......c...h.l.c...RltL.s.p......s.s...c.ht..ph..shpNulLEl+lpttp.........tt.....................	0	7	13	14
+5284	PF05456	eIF_4EBP	EIF4EBP; 	Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)	Moxon SJ	anon	Pfam-B_5573 (release 8.0)	Family	This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1 ,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F [1].	20.20	20.20	22.60	20.80	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.40	18	197	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	97	16	104	192	1	107.00	47	76.84	CHANGED	MSu....upQ...SpSpuIP.oR+VhlpDsuQLPc.sYSoTPGGTLaSTTPGGTRIIYDRpFLLshRNSPlA+TPPspLPsIPuVTh.sss.hs..........pspppsppopshpsc.......--sQFpMDI	...........................tp...o.opsIP....oRplhl..pDssQLPp.sYuoTPGGT.LaSTTPG...GT.RII.YDRKFLL-pRNSPlupTPP.ppLPsIPGVTsPss...spp............t.pp...ptsp.ptt..........t.....--sQF-MDI....................................................................	0	30	41	66
+5286	PF05458	Siva		Cd27 binding protein (Siva)	Moxon SJ	anon	Pfam-B_5606 (release 8.0)	Family	Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway [1]. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis [2]. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1 [3].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.22	0.71	-4.70	5	98	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	64	0	54	105	0	146.10	34	86.71	CHANGED	MPKRSCPFsDsAPLQLKVHVGQRELS+.GVsAERYoREIFEKTKQLLFpGAQAshD+lWsEGCuIsHpPEss+PG.TuAPc.AARGQMLIGPDGRLsRu.pAQASEAsPoG....sAshACSSCVRSVcuKusCSQCERAlCuQCl+s...CuuCuuLsColCTlsDau..DphEclLCoSCAhFEo	......................................................MsKR..Pat.ts.....QhKh+Vu.+plsp.GVhupph.pclaE..+ThpLLF.GApuh..htth.......tp....t....t......p..ps..t...s...th.p...hh.puQ.h.LlG.cG..cL...h..+s...spss.pss.ss...................ssh..s.CusC.h..R..s.ss.....s+...s.......sCupC-RslCspCsps...ChsCuslhCslCu..hs..shs...p...-pslC.sCt...........................................	0	15	20	37
+5287	PF05459	Herpes_UL69		Herpesvirus transcriptional regulator family	Moxon SJ	anon	Pfam-B_15401 (release 8.0)	Family	This family includes UL69 and IE63 that are transcriptional regulator proteins.	25.00	25.00	32.70	32.60	20.70	17.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.40	0.70	-5.19	30	149	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	84	1	0	145	0	212.20	31	39.51	CHANGED	tssttpploapcLlppsapLhppFptcshstphhpsl...Rctslpss.uLtshlAhsDEsLsWhKhphh+sLsl..pscD.IhsTusslhpsLhhKLpshh..pChLps........................................ps...thh+pLsph...................lpcps.pshps.lshslshlspaupsl.ttlpppshp......tltsh.spslpc.YpPGsshshlhpslpsHtppCssppCplthpthlsP..aspGhaFhss	............t...tttploa-pLhtpshtLhhpaphcshstphh+sh...Rphsltst.sLhphLA.sDETLuWhKhphh+s.LPl..pspDPlluTsuulhpsLhsKLpshh..tChLcs........................................ps.....lppLsch...............................hp+p..pshps.hphshshlsphuphl..slpphshp...............hltshsspthtt.YhPGsshshlhchLcsH.pcCps...chCcLphpphluP..YhaGhaFhs...	0	0	0	0
+5288	PF05460	ORC6	ORC6; ORC6_1; 	Origin recognition complex subunit 6 (ORC6)	Moxon SJ	anon	Pfam-B_16189 (release 8.0)	Family	This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins.  Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organisms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in [1].	20.60	20.60	20.90	20.80	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.19	0.70	-5.35	28	219	2009-09-11 10:55:20	2003-04-07 12:59:11	8	3	186	1	150	205	0	235.70	21	72.06	CHANGED	Lpcll........sphuts.hspcllshuspLhplSp..pppssltsppEluRshlCh.lAup...............+hppth..-lsh.hlch.PlpP+sap+hhshhcpsLtsps..........................................................t.s.t...................................................................................................................................................................................t..sh-lhplsspahlssplhs..ph.phhptacpphht....................p.httt...t...........phtstpppclp.hhslh..pthh....Wht.h..............p.....t.................................thGsMh.pspsha.hopc	.................................................tlh........sphu.s....pllptAppLhphSc....ppsuhhttppEhu+shhChclAsp.................ph.phsh........Dhs..hlphs..sls.+hYpphhphhcphLshss............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	25	71	114
+5289	PF05461	ApoL		Apolipoprotein L	Moxon SJ	anon	Pfam-B_16464 (release 8.0)	Family	Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.26	0.70	-5.17	21	365	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	72	0	177	313	0	241.10	27	74.16	CHANGED	psSpppL..LLTpccs.WppFVspAcLsR--s-sLhcsLtpLht.hshcDpsphp+s.pt...................................+chFL+tFPplKpcLc-pIccL+ALADplD+VH+ssTIoNVVuuSsussSGlLolLGLsLAPhTAGsSLsLoAsGlGLGsAAuVTuloTullEpsspstAcscAsclsssshsphcshtchltp.ssphhshsp.............shhpslcsltpsl+Al+hs+uNPpLs..usApphhssGplSspsupQVpcshtGTA...LAMo+sARIhGuAsuGlhLhhDVhsLVc-SKcLp-GAKoEoAEcLRphApELEcKLpcLsplYcsL	........................................................................................h..............................................................................................................................................................................tp.hFlp.Fsph+tcl....pp..pIpcLcslA-pl-chH+tssl.uslsuuSsu.ss.uG.lhollGLuLAPhThGsS.LhLou.sG..hGlusAuulTul..sosls-tsppppsptpspcl.hts.tppph.c.h..tp..h.htt.h.....thhph........................phh....p.....hpth...pphp.shp..hc.....h....stst.....h.ht...t.h.....s..............t......s...........p.......l..........tps.htsss..........hthspssphhshshsuh.lh....h....Dlh.ls.p.hcLtp.....G.u+sp.Attl+t.AtthpttL..h.t..t...............................................................................................................................................................................	0	41	58	83
+5290	PF05462	Dicty_CAR	Dict_CAR; 	Slime mold cyclic AMP receptor	Moxon SJ	anon	Pfam-B_16614 (release 8.0)	Family	This family consists of cyclic AMP receptor (CAR) proteins from slime molds. CAR proteins are responsible for controlling development in Dictyostelium discoideum [1,2,3,4].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.17	0.70	-5.53	6	214	2012-10-03 04:04:29	2003-04-07 12:59:11	6	7	115	0	165	697	4	215.50	19	52.21	CHANGED	hps.pEIcsoYulLLIADFoSIIGChlVLIGFWRLKLLRNHlTKVIoCFCsTSlhKDlhSTlLTLo....ssAsps.GFPCYLYAIVITYGSLACWLWTLCLAhSIYpLIVKREPEPE+aEKaYahlCWGLPLISTIlMLuKsslchVGNWCWIGspYsGYRFGLFYGPFFhIWulSAlLVGLTS+YTYpVI+NuVSDNKDKHhTYQFKLINYIIVFLlCWVFAVVNRIlNGLshFPsssNlLHTYLSVSHGFaASVTFIYNNPLMWRYaGuKllhlFThFGaFVEsQ+RLEKNKNNNNPSPhusS+uuo	.......................................................................................ttt..........................h......Sh..hu...s...hh.ll.hs.a...hh...p.......h+....p.............................+..h.l.h.h......h..s...h...ss...h...h....s...h....h......s...h....h..........h...................t....t......s......sh.......h.C...hQuh.h.....l.phh....u..s..h........h.....Ws.h...s..hA....hs...l...a....h...........s..h...h...p....p......s...p..h....c..+....h...c..h.....h....Y.h..l...h.s....a.G..l..P.h...l..s..s.....h...l.....h....h..............h.........t.....p......t......h......t..............h.......G........s....W..CW..l....p.........s...........p..............h.........s...........s..........h......R.......h....s................h.......FY.s...P.l..a...h....l......h....h....h.........h...h......h...h..h....h..................................................................................................................................................................................................................................................................................................................................................................hhhhhh........................................................................................................................	0	74	115	151
+5291	PF05463	Sclerostin		Sclerostin (SOST)	Moxon SJ	anon	Pfam-B_16740 (release 8.0)	Family	This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterised by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients [1].	20.60	20.60	21.40	20.70	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.33	0.71	-4.83	4	114	2012-10-02 16:54:34	2003-04-07 12:59:11	6	3	45	3	56	111	0	177.90	50	95.52	CHANGED	hphsLl..LlClLh+uCh.........AFKNDATEll.uHs.tsh..cssNNuoLNpARNGGR+spss.hDpss.pQVGCRELRSTKYISDGQCTSlpPlKELVCAGECLPh.lLPNWIGGGa...YWSRRsuQEWRCVsD+TRTQRIQLQCpDGoT.RTYKlTlVTSCKCKRYTRQHNESSHs.pusSss+P........up+pRs+KRtuKsspppLo	..........................................hh..LhClLh+ush.........AFKNDATEIl.phs.ts................s.....ps......p....s..NsT..h.Np.AcNGGR..p....ps.....h-p.p.st.sphuCRELRST+YloDGpCpShpPlKELVCuGpClPh.lLPN....h.IGtGh.....W.Rpsu.p.-aR.Cl.sD+oRTQRlQLpC.sGss.RTYKlplVTuCKCKRaTRpHNpSph.p.....uhpsu+P........sp+..+..+t+suKsspt.........................	0	6	11	23
+5292	PF05464	Phi-29_GP4		Phi-29-like late genes activator (early protein GP4)	Moxon SJ	anon	Pfam-B_16889 (release 8.0)	Family	This family consists of phi-29-like late genes activator (or early protein GP4). This protein is thought to be a positive regulator of late transcription and may function as a sigma like component of the host RNA polymerase [1].	21.60	21.60	22.10	222.80	19.60	20.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.46	0.71	-4.24	3	7	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	8	0	8	0	125.40	73	99.32	CHANGED	MP+TQRGIYHNLKESEYVlS..NGDVTFFFSSEMYhNKFLDGYQEaREKFNKKIsRlscT.PhNMDMLADITFYSpVEKRGFHAWLKGDNsTWQElHVYALRpMTKPsTLNWSRIpKPKLRERRKSMV	MP+TtRGIYHNLKESEYVsS..NsDsTFFFSSEhYLNKFLDGYQcaRccFNKKIpRlssT.PhNMDMLADITFYSpVEKRGFHAWLKGsNsTWpElHVYALRhMTKPsT.sWSRIpKPKLtERRKSMV	1	0	0	0
+5293	PF05465	Halo_GVPC		Halobacterial gas vesicle protein C (GVPC) repeat	Moxon SJ, Bateman A	anon	Pfam-B_17013 (release 8.0)	Repeat	This family consists of Halobacterium gas vesicle protein C sequences which are thought to confer stability to the gas vesicle membranes [1,2].	22.30	22.30	22.70	22.90	21.80	22.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.34	0.72	-3.95	29	50	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	7	0	20	45	0	32.00	32	48.53	CHANGED	VssLhssIsshcppassspsuFcsYu--Fsss	..VssLhssIsshcpphssspsuF-uYu--Fss.......	0	10	14	20
+5294	PF05466	BASP1		Brain acid soluble protein 1 (BASP1 protein)	Moxon SJ	anon	Pfam-B_16137 (release 8.0)	Family	This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of unknown function [1,2].	25.00	25.00	77.60	48.80	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.10	0.70	-4.54	6	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	28	0	28	49	0	175.80	58	98.29	CHANGED	GGKLSKKKKGYNVNDEKAK-KDKKAEGAuTEEEGTPKEs..EsQAAsEoT.EVKE.spEEKP-KDApsotsKsEEKEGEK-AsssKE-A.KAEPEKoEuuA-AKsEPsKs......sEpE.AAAsuPAsuuEAP..KAuEsS.....stsAEuAAPup.--.SKEEGEAKKTEAPAu.AupEsKS-uAP.ASDSKPSSsEAAPSSKETsAATEAPSSTsKApsPAAPA-EsKsuEuP..AANSDQTVAVpE	.........GGKLSKKKK.GYNVNDEKAKDKDKKAEGAusEEEsTPKEs..EsQsAu-ss.EsKE..tcpKs-pDups...KsE-KEu-K-ss.spE-s.KuEsEK.oEu..s-upsEP.ts......scpp.tAssuPusss-As..Ks.sEst.......su-s.Asst..p.u+EpGEsKKTEAPAs..hpEsKS-sAP.ASDSKPuSsEAAPSSKET.sA....TEAPSST.sKA..tP.u...uss-p...sEsP..ssNS-QoluVp-..................	0	1	3	9
+5295	PF05467	Herpes_U47		Herpesvirus glycoprotein U47	Moxon SJ	anon	Pfam-B_17115 (release 8.0)	Family	\N	25.00	25.00	80.50	80.00	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	677	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.45	0.70	-6.68	2	53	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	7	0	0	25	0	119.00	85	96.88	CHANGED	MLHISpLGLFLuLFAIVMHSsNLIKYTSDPLEAFKTVNRHNWSDEQREHFYDLRNLYToFCQpNLSLDCFTQILTNVFSWsIRD.QCKSAVNLSPLQNLPRsETKIVLSSTAANKSIlASSFSLFYLLFATLSTYTADPPCVELLPFKILGsQLFDIKLT-ESLpMAhSKFSNSNLTRSLTsFTsEIFFNYTSFVYFLLYNTTSCl.SNDQYFcpSPKPINVTTSFGRsIVNFcSILTTTP....SSTSASlTSPHIPSTNhPTPEPsPVTKN.TcLpTDTIKVTPNTPTITsQTTESIKKlVKRSDFPRPMYTPTDIPTLTIRhNATIKTEQNTE....NPKSPPKPTNFENTTIRIPcTFESsTVsTNsTQKlESTTF.TTIGIcEIssNhYSSPKNSIYLKSKSQQSTTKFTDsEHTTPILKFTTWQssARTYMSHNTEVQNMT...................................................DRFQRTTLKSSsE.PTlQTLSVTPKpKLPSNVTAKTEVplTNNALPSSNSSaSITcVTcEsKpsRMSASTHtEINHTEIsphTPILNAHT.EKSTTPQhsFTAET.LTTSSKsAILTWSNLL.TTPKEPLTNTSLR.TsHITTQLTTSNRTQSAKLTKAplSSQTTNIYPQTITtRST-V	...........................................................................................................................................................................................EESLRMAMSKFSNSNLTRSLTSFTSKNFFNYTSFVYFLLYNTTSCVPSNDQYFKQSPKPINVTTSFGRA..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+5298	PF05470	eIF-3c_N	eIF3c_N; 	Eukaryotic translation initiation factor 3 subunit 8 N-terminus	Moxon SJ	anon	Pfam-B_17447 (release 8.0)	Family	The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA [1].	20.70	20.70	20.80	20.90	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	595	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.99	0.70	-6.43	8	593	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	302	0	373	561	13	373.20	28	67.47	CHANGED	+ahpssssp-usDEEDsKRVVKSAKDKRFEEhssslcpI+NAhpIsDhlslppsFDcLsKthpKsh....hp-sstsPshYI+sLstLEDaLNch.ssK-uKKphSpuNuKALNoh+QKlKKsN+..paEDcIs+aRcsPEp-s-cssE---s-ssGssspscs.ssshtsp.lst.....s.pu.................................................................................t....t.tst......hs...h..c.hhhpcscEITassVhKKLpEIhsARGKKsTsRp.......pplcpLpcLscIAcpssp....plcIhFslISApFDlNs.slSsaMPI-hWppslpshpolLDILltsssIhls.phsDpsE..Ep-spc..shsGslRVpGslluFlERlDsEFhKSLQsIDPHos-YVERLKDEsphhsLlpplQcYlEcpGcs.....+sss+lhl+RlE+lYYKscplhch.......................pptt..ss.hsshchssct.shs-sScsLMDtLsshIY.Ksss-Rl+sRAMLCcIYHHALpDcFhpARDLLLMSHLQ-NIpHhDluTQILaNRTMsQLGLCAFRtGhlpEuHpsLs-LhSouRlKELLuQGl.tsR.HE+TsEQE+lERpRQ.lPYHMHINLELLEsVYLsCAMLLEIPpMAAspaDA	.....................................................ht.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h......................................................................................................................................................................................................................................................p..t..............h.........................................................................................................................................................................................................ht.h....l.........t..t.....t.tuhL..h.a..uh.tpa..u+-hhh.uth.p.h..........-...p..............lhaNRhhsplGlsAF+.s.h.cspthL.-l......t.t+...........+-.ll.uQt........................t...s.pt...............ph.c+th..hPhH.Hlsh-ll-.h.hhsuhhl-ls..s.......................................................................................................................................................................	0	131	215	314
+5300	PF05472	Ter		DNA replication terminus site-binding protein (Ter protein)	Moxon SJ	anon	Pfam-B_17662 (release 8.0)	Family	This family contains several bacterial Ter proteins. The Ter protein specifically binds to DNA replication terminus sites on the host and plasmid genome and then blocks progress of the DNA replication fork [1].	22.00	22.00	22.00	23.20	21.10	21.90	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.78	0.70	-5.29	23	673	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	604	5	60	325	12	282.80	59	95.91	CHANGED	pclsspFcplppcLttLpptLsstphltA+VaslPsVt+spE+.cslspItVpphhGppAhshulctapclaIp.....pshSoKushRhPGllshsssstp...plhshIscINplKsshEplIsspss.spptRF..............EhVHpp.LPGLlTLpsYRplpslp...s.solRFuWtp......K+sl+sho+..cclLttLcKuhpssttssshs.cppWpttlspEhpplsp..LPpcspL+I+RPVKVQP.lAplaa.....psp.......pcphphssshPlIsl.....sspsPclspL.hsYDssshp....+h+spttshclLls..RLHlYh	......................................................................RLNsTFRQhEQcLAshsspL.pQap...LLlARVFSLPpVpK-sE.....H..sPLs....pIcVp.QHLG.p-ApsLALRHaRHLFIQQ....................QSENRS.SKAAVRLPGVLCYQ..VDNhoQ.tsLhspIQ+INpLKT....TFEclVTVES....t.....LPoAARF...........................EWVHRH..L.P.G.LITLNAYRTLTlLp...sPATlRFGWAN......KH.I.IKNLpR..DEVLuQLEKSLpSP..............RS.VsPWT.REpWQpKLEREYQDIAA...........LPQpA+LKIKRPVK....VQP.IARVWY......KGp........QKQVQHACPTPLIALINpDNGAuVPD.lGEL.hNYDADNlQH...RaKPQAQPLRLIIP..RLHLYV................................................................	0	6	18	36
+5301	PF05473	Herpes_UL45		UL45 protein	Moxon SJ	anon	Pfam-B_17674 (release 8.0) & Pfam-B_16138 (release 10.0)	Family	This family consists several UL45 proteins. The herpes simplex virus UL45 gene encodes an 18 kDa virion envelope protein whose function remains unknown. It has been suggested that the 18 kDa UL45 gene product is required for efficient growth in the central nervous system at low doses and may play an important role under the conditions of a naturally acquired infection [1]. This family also contains several Varicellovirus UL45 or gene 15 proteins. The Equine herpesvirus 1 UL45 protein represents a type II membrane glycoprotein which has found to be non-essential for EHV-1 growth in vitro but deletion reduces the viruses' replication efficiency [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.35	0.71	-4.89	11	167	2012-10-02 16:37:33	2003-04-07 12:59:11	7	22	100	0	44	725	1	141.50	17	27.58	CHANGED	osospsptPLsshcs...h.............suspspRs+p.s.sss.......................hhhshhslGlllTshlllushl....hslPhsuhpsusCPspWhGlssuClRssspss.....spppAsssCuthsupllspusAptLhsllsshusssus.h.....................hssDultsClpsstussh..p..CspsuhsIC.tsRslSshuphIhcsRpuLpL	.................................................................................................................................................................................................................................hhhh...s.h..h......hsh.....h..l.....h........s...hl.....................h....t..........s.............t........s....h......t....t.......t..............CPpc.Whsa...s..s.sC.h.thss.sst............sappApshC.p.s..h..s.....u..p...l...h...s.......s......s..................h..........hh.t.............................................................................................................................................................................................................................................................................	0	11	14	33
+5302	PF05474	Semenogelin		Semenogelin	Moxon SJ	anon	Pfam-B_18147 (release 8.0)	Family	This family consists of several mammalian semenogelin (I and II) proteins. Freshly ejaculated human semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicle secreted semenogelins (Sg) [1].	19.10	19.10	19.10	19.10	16.90	16.00	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-13.19	0.70	-6.22	4	125	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	26	0	7	129	0	273.00	43	97.46	CHANGED	MKPIIhFVLSLLLILEKQAAVMGQKGGSKGQLsutSspFPatppu.pYSu.KDKQHsESKGShSIpHTaHVDspDHDpTRKSpQYDLNAQpKTTKScpa.tGpQELhNaKQEGR-+uKsKscFHhlVIHHKGGpspHGTQNPSQDpGNSTSGKGh.SQ.SNTcEpLhspGLuKEQsSsSGAQ+sRTQGGSQSShVLQTE-.Vs....NKQp.ETQNShpNKGpY.NVhEs+pcHSSKlQTSLasAppcRLQHGSKDlFo.........KNQ+QT+NhNQDQEHGQKAHKtShQsSST............................................................EERRLsauEpGIQKDsSKuShSpQTt-KhhsKSQpQlThPSQ-p..up+tNKhS.QSSusEERR.p.GEpGlQKsVspuph..pTE-KIHsKsQNQlTIPSQDQc........................................................................................................................SGQsAKGpSGQSsDREpDLLS+EQKsRHQctspGuhNlVIIEHEsspD++.sQ++spDpNslsT	.............................................................................................S.h.lphhaHs..pstD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	3	4
+5303	PF05475	Chlam_vir	Chlamydia_vir; 	Chlamydia virulence protein PGP3-D	Moxon SJ	anon	Pfam-B_18238 (release 8.0)	Family	This family consists of Chlamydia virulence proteins which are thought to be required for growth within mammalian cells [1].	25.00	25.00	31.10	31.10	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.63	0.70	-5.28	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	20	0	1	29	0	207.60	73	99.67	CHANGED	MGNSGFYLpNTQNCVFADNIKVGQMTsPLKDQQlILGTTSTPTAAKhTAc-GIslTs-ossSTNASITlSLDuEAlhK....LIL-QIpD-LVcuIIcNITsSLIQEVIDKIpoDPSLuLoKAFKNFsITNKIQCNGLFTKcNIGTLLGGTEIGoFTVTPDNAsSMFLISADIIASRMEGsVVLALVKEGDSuPCAISYGYSSGlPNlCSLRTsVuNoGssPVTFSLRVGGMESGVVWVNALuNG-cILGlTsTSNISFLEVKPQTNG	.........MGNSGFYL.sTpNCVFADNIKlGQMppPLpDQQlILGTpSTPsAAKhTAs-GIslTlSNssusNASIsluLDAEpshp....LIL-pltcpIlDuIhcsIssShlQ-llDKIpoDPSLuLhKAFpNFsITsKIQCNGLFTsSNItTLLGGTEIGKFTVTPcsusSMFLlSADIIASRMEGsVVLALV+EGDopPCAISYGYSSGlPNlCSLRTslpNoGhsPsTaSLRVGGh-SGVVWVNA..LuNGssILGhTsTSNlSFLEVh.QTNu.	0	0	0	1
+5304	PF05476	PET122		PET122	Moxon SJ	anon	Pfam-B_18328 (release 8.0)	Family	The nuclear PET122 gene of S. cerevisiae encodes a mitochondrial-localised protein that activates initiation of translation of the mitochondrial mRNA from the COX3 gene, which encodes subunit III of cytochrome c oxidase [1]. 	22.30	22.30	22.50	22.60	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.86	0.70	-5.14	5	30	2009-09-10 15:37:49	2003-04-07 12:59:11	6	2	29	0	15	26	0	249.50	45	89.80	CHANGED	MLlIsRRLVsT.-VR+RLYspCLNt-hsulLspLRQIsVscMDhSLLpLhLs+SspaGHl-oIsYlWYKYVhRH+.LhVEP+LLCDIuslALtQGKLFIPuQlLpHYQsh.YG+Gppt...sEhppaEYELpRIKVEuFAKGTMcsToFsEKWKVFLQ-MDpTLPuss.aclRDFPaLT+A......LhQTDEps......htphLFu-pclsVsNcoSLPLLLNhVLLQ.ssFsL-sRlRlFpcFhpoYRuLPlpDolEIlIK+s..psYh..cLhphl....RGhEIsT	...................s+Rhlos.DlRpRllLssLNtchs-ALshLRpp..ppsshDspLLpshLARAsthAHs-oIsYhWYpaVM.++.LsVcs+LLC.-MAslALap-+hFLPuQhLpHYpsh.hc++ss....sEp-hlEYELhRIKVEuFA+GTMcuTuhREKWKVFLQ-MD.o.....LPupsshRlRDFPphTKu......Lh.ppDEps......huhhLFsc.p.lsIKNcaSLPLLLshlLhp..s.hssps+.+lhtcFh.p...oY+uL..s.L.hDu.pllh+c......cGacl..................ss..................	0	1	6	12
+5305	PF05477	SURF2		Surfeit locus protein 2 (SURF2)	Moxon SJ	anon	Pfam-B_18437 (release 8.0)  	Family	Surfeit locus protein 2 is part of a group of at least six sequence unrelated genes (Surf-1 to Surf-6). The six Surfeit genes have been classified as housekeeping genes, being expressed in all tissue types tested and not containing a TATA box in their promoter region. The exact function of SURF2 is unknown [1].	25.00	25.00	28.60	28.60	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.77	0.70	-5.24	8	115	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	75	0	69	99	2	210.00	30	81.53	CHANGED	McElPpDV+uFLppHPsLcLs.-up...KVRChLTGHELPCpLsELQsYTcGKKYp......+Lspupss..FsYspaEPHIVsSTKs.pQLFCKLTLRHINKpPEHVLRHlpGKRYQ+ALppYE-CpcpGVcaVPApLhpKp+.+c...spcsuscpP.p+p-s.......hWtPsS....S-E-sutS-DSMoDLYPsphFs.Ks.sp.ps.t....t.-sFpTD.c-....--hthcspp.p...............pKRu...KKQsuuhpKKFKpsH+Kspphp.uSsK	..................................phtthLtppP..hph..sss.......+l+CtlTGHElPsp.hs-lpsYscuKKYp......+.L...p...s..p..p..hs.aspa-PHll..s.ss..c.p...ppLaCKLThcplNKpsEHlh+HlpG+Rap+tLpchEcspp..p..G....h.chh.....up...h..p........c.tp..p.pp.........pp.ss.st.....t.ppt......................hW.P.s......scpp....t.scDs.....hsDh...hss..t.h...tp.t.ttp....t.........................t.psh.....sc.....pp.......ccht......t...........................p........t.......t..tpc.p...............t.....................................................................	0	25	37	53
+5306	PF05478	Prominin		Prominin	Moxon SJ	anon	Pfam-B_18226 (release 8.0)	Family	The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain [1]. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration [2].	31.00	31.00	31.30	31.10	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	807	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.42	0.70	-7.00	14	435	2009-01-15 18:05:59	2003-04-07 12:59:11	6	11	96	0	229	399	0	541.40	21	85.92	CHANGED	luhststhssupst.....t.htas.hhssppapsps....hsstshsslashs+phls...sVpspP.hPp-hlht...lhpsshshtsphp.p.........clltaphGhllsul....IulLallLMPllGl...CFCCC.RCptsCGGchppp-pppssCc.RthhslhLllholhlhhGllhuFlsNphhppsltpospthppslcDlpsalsssspplctlhsp.YpphpspltppLsssu..phlsstlpsphcupllssLpplhp..............slptscctLpslssphpcL+ptuspLpssLpuhRpplpssLsp..Cpsp........Csslh.shs.ltls....hcasplPslsp.lpslpplscsshsshlpcGhsphpplstplpppspssl....shpptLsshssslcshupplstp.ltsshsphhpssppphcshts.lccYspYRahsulllsslllLllhh.h.hGLLsGlhG.c+pssPsccsCsussGGpFLMhuVuh.FLhshhlhllslhhFllGuNsppllCcsh...pspplh.p.hlDoPh.Lst....htluthL.........phshslpl.....uplhcsCcpNpslassL+Lpshaslschhslpp...hopc.lppphpsl+l...slssl....plLsspu+csLpshtsoslschsassalpplp+slopssLsshApcLctlAsshssss......................l+ssLppcApsl+slppshlsshpshlscLppslpsL-pp....ssphstslsplLsplptupthlsspspphltptocphhsphlshhppYlsaVhpplspclupCpPlushhDsuh.shhCshllD......PhNuFW....huluhCthhhlPslIhuVKLuphY++hc..ss.ss	...................................................................................................h.....................................................................................................................................h.h...hhhh....hh.h....h.hhh.h.hhh.hPhhuh...hhshC..R........h.h......t.......t.......ts......s.p.........p.......pt.....+.hh....h...L.h.h.h..hh.h......hu.h.h.h.ahs..sp.hpt.t..ht...............h.psh.shp.hhpp...............s..ph.p.hlh...ht...p...ph..tlptht.....l..h..l.t....t...t..h...h..tth.t...................................sh.......h..hp.....ht...t.ht.t.lp..p.pl...htt..C.......................C......t...h..t......t.....s.............................p.t....h.........p.........thp....h...t........p.h...t...tt..t.hpth...ht.pht......h................h....t.htp.........t.h..t......p.h......h.....h...hh.t...............t........t...............h....p....ph....t....h.hh.shhh..hlhhlh.hh.h.huLhhG.hu..................ttsuu.hhhh..............uhhh.Fhh..hhhhlshhhhhhGssh.phhCtsh.........tptphh.p....hh...Dp.h.h................h..................................t....lph.....tphhptCpp..s.tshathhp.hpp...hslp...phh.p..hp....h..t..h..t..hpth..ph......shp...h........hlt.t.t..p..L.th..ts..htthp...hh.t.htt..s.........h....s...l..thttpl.pt..st...................................ht....th...t.s.thp..th.......p.h.............h......t......th..plt.lpt....................th..tht.h..lttht.hp..l.t...p.ht.hh..t.sp...thhtt..t.hppYhphh...tht.phutCtPhsthh.pps.....h..hCphhhs......sh...NhhW.....hslhh..shhhh.lP.lhhshph.phap..........s...................................................................................................	0	60	78	167
+5307	PF05479	PsaN		Photosystem I reaction centre subunit N (PSAN or PSI-N)	Moxon SJ	anon	Pfam-B_18582 (release 8.0)	Family	This family contains several Photosystem I reaction centre subunit N (PSI-N) proteins. The protein has no known function although it is localised in the thylakoid lumen [1]. PSI-N is a small extrinsic subunit at the lumen side and is very likely involved in the docking of plastocyanin [2].	19.60	19.60	20.00	20.80	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.67	0.71	-4.19	3	69	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	37	4	31	62	1	113.70	42	77.64	CHANGED	Vusup+A.sAlsQuA+PARAssVsVcuSssRRSALLGLAAlLuuTAAlAuSANAGVlDEYLEKSKsNKELNDKKRLATSGANFARAaTVQFGSCKFPENFTGCQDLAKQKKVPFIoEDLcIECEGKDKaKCGSNVFWKW	.................................................t...............t......t..s....t...s.p.RtuhlhLuus.lhssA..u....s..u...s..ApAull--YLcKSKANKELNDKKRLATohANhARuaTVpFGoCpFP.NFhGCp-LAhpptV.als-DhtlECcG.+.pth..CuSp...........................	1	6	17	24
+5308	PF05480	Staph_haemo		Staphylococcus haemolytic protein	Moxon SJ	anon	Pfam-B_18620 (release 8.0)	Family	This family consists of several different short Staphylococcal proteins, it contains SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic activity (SLUSH), phenotypically similar to the delta-hemolysin of S. aureus [1]. Gonococcal growth inhibitor from Staphylococcus  act on the cytoplasmic membrane of the gonococcal cell causing cytoplasmic leakage and, eventually, death [2].	25.00	25.00	32.10	31.90	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-7.91	0.72	-4.27	16	511	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	209	0	20	79	0	43.20	59	96.71	CHANGED	MstLs-AIsssVpAGlspDWuplGTSIlsIVtsGVshlu+l...FG	..MpGLh-AItsTVpAA...spDusKLGTSIVsIVtNGVGlLGKL...FG.....	0	2	2	20
+5309	PF05481	Myco_19_kDa		Mycobacterium 19 kDa lipoprotein antigen	Moxon SJ	anon	Pfam-B_19467 (release 8.0)	Family	Most of the antigens of Mycobacterium leprae and M. tuberculosis that have been identified are members of stress protein families, which are highly conserved throughout many diverse species. Of the M. leprae and M. tuberculosis antigens identified by monoclonal antibodies, all except the 18-kDa M. leprae antigen and the 19-kDa M. tuberculosis antigen are strongly cross-reactive between these two species and are coded within very similar genes [1,2].	26.90	26.90	26.90	27.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.10	0.71	-4.41	3	187	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	93	0	41	162	0	147.20	38	96.88	CHANGED	M+RpLpsAVAGssILsAGlSGCSSGNKS.TPSSScTToSouTTAS...PGAAAGs.KVlIDGKDQNVSGSVVCTTAuGsVNIAIGGAATGIAAVLoDGNPPpVKSVGLGNVNGVTLGYTSGTGQGNASATKNGNoYKITGTATGVDMANPhQPVNKSFEIEVTCs	.....................................................h.sGC..us..t.....t....s...stts.sss.ssu...........ss.s.s..uG.....s...pV..slDGpsps..s..ss.sVs..Csssu..........G..p..hsI...u.I...G..s.....s..s....s...G....l.uAVlo.s.G.ssP.pV.cSVu..L....GsV..sG......h..oLua..sp..GsG..t..G.sAsss+DGspYpIoGTAsGs.DhuNPhp..slsKsF-IcVTC...............	0	2	19	33
+5310	PF05482	Serendipity_A		Serendipity locus alpha protein (SRY-A)	Moxon SJ	anon	Pfam-B_19519 (release 8.0)	Family	The Drosophila serendipity alpha (sry alpha) gene is specifically transcribed at the blastoderm stage, from nuclear cycle 11 to the onset of gastrulation, in all somatic nuclei [1]. SRY-A is required for the cellularisation of the embryo and is involved in the localisation of the actin filaments just prior to and during plasma membrane invagination [2].	19.00	19.00	60.30	59.50	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-13.02	0.70	-6.07	4	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	32	0	26	68	0	427.70	41	87.27	CHANGED	MEpLLtQLslCsELIApG.oCssGpIuWLNEFCATFLDFAS-LKA+LPElAP+..h.EGGsNI-VETIFLCLTQVVTCITQLERTINIEus.uttsp..MTRhHFLDRIDWClRRlhsSLoQLc.pttssssssLEDHoFVELMDLALDHLEsaMEtLusposs..LhI.EEs-op-hhQLuSIVNHIVRHALAFANVALEuDKKALStLCETLLuECuTFhEsuuEhNPGHRKLEALSLERALYuLETaLNEALLHLIFsSll-LENssIp+LRcALQpp.-..Suhs-pLlSDFDTNMDRIQQIGVLAIAFSQDlKTKTIVRSCLASLESLDACIVPALQ..poo.usHHADILEHHFNpElLIFRNlIHEIIDSRSLINNYLDMLAES..IHlAsK..P+saL.LIVQMGuVlh-HFRLPVNYStL..S-.DGKRlHpDhlLIL+EC.AVVslus.VDPKRIVKRLKILYSVLAKLRDlID+s.h.+-.......s.s.......Sc+phTsATRThlR..+ShuKRQRSFV+QptsssVssPps..sSlusSlSp-uDLISFQLTEILRIs	...........................................................................................................................................................LNthCu.hhphsp.hp..h....................Ehhh.LCloQlhhClp.lEpshphpt....................o+.aFlDRlpaClp+lhh.h...........t.t.s...t....htc.sFlplhDhuLDhlt.h.ph..ppspt..............p.h.....s.hpLtshlspllppALAFANVAl.ppDK+ALouLCppllpECs..sFp..cp..s......t........c.sss.u....p....p....KLcAhoL..............EcALYtLEsalN-ALL+L...lFsshhDh-...pt...ulcKL+....sh...Lp........p.s.......sstsp..clIusFDsNhDRlpQIGlhAIAFupclKtKThlRSCLASlESLDssllPuLQ..........u..suushHu-lLppHFppEhhhF+sslpEIIDSpuLls.sh........L-hLs-p..I....cst....pp.....+phL......llQhu...tllh.cHFpL.lNh..psL....sc....p....G.pch....a......p...chlhlLpEC.p.A...l.....l...........h....ss....l-...Pp..............RIlKRhKILholLtKL+ssls..tt................................................................................................................................................................................................................	0	6	8	20
+5311	PF05483	SCP-1		Synaptonemal complex protein 1 (SCP-1)	Moxon SJ	anon	Pfam-B_19633 (release 8.0)	Family	Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase [1].	19.50	19.50	19.50	20.10	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	786	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.95	0.70	-13.70	0.70	-6.76	2	74	2009-09-11 15:44:23	2003-04-07 12:59:11	7	4	40	0	35	67	0	520.20	42	79.88	CHANGED	hGGDSsaFKohNKCTEsDFthPhshosLSKNtENIDoDPAhQKlshLPhLEQVuNS.sCHYQEGlpDSDhENSEshSRlYSKLYKEAEKIKKWKVShEuEL+QKEsKLQENRKIIEAQRKAIQELQFtNEKVSLKLEEtIQENKDLIKENNATRHhCNLLKETCARSAEKTpKYEYEREETRQVYhDLNNNIEKMIhAFEELRVQAENuRLEMHFKLKEDaEKIQHLEpEYpKElNsKEpQVSLLLIQ.TEKENKMKDLTFLLEESRDKsNQLEEKTKLQsENLKp..EKpcHLTpELEDIKhShQRShSTQKsLEEDLQIATKTIhQLTEEKEsQMEE.NKA+ssHShVVTEhcsTsCoLEELLRTEQQRLEpNEDQLKllTMELQKKSSELEEMTKhpNNKEVELEELKplLuEcppLL.EpKQhEKlAEELpGpEQELhhLLQsREKElHDLElQlTshpTSEpaY.KpVc-hKTELEpEKLKNhELTupsshL.LENKcLsQEsSDMsLELKppQEDI.NsKKQEERMLKQIEsLpEpEhpLRsELE.VRcEhhQptDEVKCKLDKSEEN.....................CNNL+KQlENKsK.IEELpQENKALKKKuoAEsKQLNsYEIKVNKLELELtSsKQKFtEhhssYQKEIE.KKISEEpLLtEVEKAKshsDEAVKLQKEIDhRCQHKIAEMVALMEKHKHQYDKIlEERDSELGLYKs+EQEQSSh+suLEhELSNl+sELlSlKKQLElE+EEKEKLKhE.pENTAhLp-KK	..............................................................................................................p....s...plaSKLacEsEKIKpWKlph-u-lpQKEp+LQEN++hIEsQRKAIQELQ...FtNEplSlKLE-tIpENcDLhpcNNATRpLCNlLK-Tht+osEKhphaE.EREET+plah-.spNlp+MlhAFEpLRhQAEssp.EMp...KlKEph.phpcLcpchctEhp.KEcplulL.hp.p-KEschcclhh.LpEopcphspLpEtpp.ppE.LKpu.tcpctLhpcLp.hp.sh...pct.tsp.cslp....pLp.s...hcph.plhtpK...-sphEp.pph+..ps..ltphphshtpLpp.Lp.E.p.Rhpp....cp.p.p.h..-Lpp+sttltphhc.pp.pchp.lp..Lpp.Ltptp........pp....hpth.tphp.tpppl..h...l.....hptphtchp.....hts.ht.tpp....ph.phpt.phpp...t.h+p.pL..php.l..p.ptth..ph..h..p.p..................................................h......p.ph.......ph.....t...........................h......hc+......t....pp..tp..ct..hpppNchLKKp.stE.pp.p.h.phplspLp.Ehpshpp.htE.hpph.c-lc..pKph.t..tpL.tElcKh+hhssEulK.pcEh-h+CQpKIs-MlALMEKHKtpYD+hlEE+DuELt.hp.+EpEt.u.hctuLE.ELsphcs-l.pl+.pLc.ph.tc.K.........................................................................	0	6	8	17
+5312	PF05484	LRV_FeS		LRV protein FeS4 cluster	Bateman A	anon	Bateman A	Family	This Iron sulphur cluster is found at the N-terminus of some proteins containing Pfam:PF01816 repeats.	20.90	20.90	21.80	35.20	20.10	20.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.03	0.72	-4.39	4	74	2012-10-11 20:01:00	2003-04-07 12:59:11	6	6	68	1	40	71	0	55.80	44	21.33	CHANGED	usEsl...s.hs-CRsCpFc.sLL.oGRCs.GcuCVss+puRpIDRFFRpNPpLAscY	........s..tslDWpGp.lcCssCsHc...slh.sp.G+..Cc.s+ACVpDRYARRIDRFFphNPsLAspY...	0	12	28	32
+5313	PF05485	THAP		THAP domain	Bateman A	anon	[1]	Domain	The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.33	0.72	-3.81	139	1658	2009-01-15 18:05:59	2003-04-07 12:59:11	7	123	120	6	1163	1895	1	83.30	23	22.91	CHANGED	ppCss......sC...........tpppppps.lphacFPp...cpp..hht.pWhpshptp................sppt.......tlCspHFpspsh.................ppppLpssA......VP.......olh..ttspt	.........................Css..sC.......................tp..p.p..pp.s...lpha........p.F.....Pp................c..p.......hhp..pWhpshpppsh...............t..pppt..........hlCupHFp..sp.sh..........................tp.ptLp.sA.......lPolh.....s............................................	0	346	432	912
+5314	PF05486	SRP9-21	SRP9; 	Signal recognition particle 9 kDa protein (SRP9)	Moxon SJ	anon	Pfam-B_7787 (release 8.0)	Family	This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP [1]. This family also contains the homologous fungal SRP21 [2].	20.90	20.90	21.90	23.20	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.54	0.72	-4.24	33	286	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	247	3	199	271	1	80.00	33	58.17	CHANGED	alpshppFlctSppLhpupPspTRhohKYpt........................................sssslslKsh-spsu.ClKY+TsKut-luRLlshhG.husshs	........hpoh--FhctuppLatusPp.psRhshKYpa.............................................................scupLslKspDsts..CLpY+Tspup-lp+l..p.h.hupLhphh.s.............................	0	59	99	155
+5316	PF05488	PAAR_motif		PAAR motif	Yeats C	anon	Yeats C	Motif	This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins.	23.00	23.00	23.00	23.10	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.68	0.72	-3.99	88	2205	2009-01-15 18:05:59	2003-04-07 12:59:11	8	110	944	0	577	1932	242	74.40	27	19.69	CHANGED	lhh.GDp.TspGGpV................l.su..usshhhsGpslAhhG..........D..hssCPts.......usssIlp..G..s.s..shhhsGpslAhpGcpssC...........Gs.....pLluu	.......................................................................................................................p.sG..l....................h..sG..ssshhht..Gh..ss.AphG.........................................................................D......hs.sCspp................ssshIsp.....G.s..s....slh...l...s.GpPsA.phGc...ps.s.C...................Gu........hlh...................................	0	76	220	365
+5317	PF05489	Phage_tail_X	Tail_X; 	Phage Tail Protein X	Yeats C	anon	Yeats C	Domain	This domain is found in a family of phage tail proteins. Visual analysis suggests that it is related to Pfam:PF01476 (personal obs: C Yeats). The functional annotation of family members further confirms this hypothesis.	20.60	20.60	20.60	20.60	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.81	0.72	-4.49	32	981	2012-10-01 23:00:54	2003-04-07 12:59:11	7	7	753	0	144	576	23	58.70	40	67.46	CHANGED	MKsaAl.QGDTLDAIClRYYGRT.EGVVEsVLAANPGLAELGsVLPHGTAVELP...DVQTAPVA	...............................pshuh.pGDTl..DuLCaRaY..Gc...o..pG.ss...E.pVL.p..A..NPG.....L.....Aph....s....h..LPtGhtVplP...-lptt.........................	1	29	67	110
+5319	PF05491	RuvB_C		Holliday junction DNA helicase ruvB C-terminus	Moxon SJ	anon	Pfam-B_844 (release 8.0)	Family	The RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein [1]. This family consists of the C-terminal region of the RuvB protein which is thought to be helicase DNA-binding domain. 	24.70	24.70	24.70	25.80	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.30	0.72	-4.35	126	4372	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	4328	12	944	2793	1004	75.80	54	22.41	CHANGED	VDphGLDphDR+hLpsllcpasGGP...VGl-TlAAuluE-psTlE-VhEPYLlQpGalpRTPRGRlsTptAYpHLshs	...VDptGLDhhD++lLpslI-pFsGGP...VGL-TLA...AulGE.EpcTIEDVhEPYLIQpGFlpRTPRGR.lATspAYpHhGh.s.....	0	325	633	805
+5321	PF05493	ATP_synt_H		ATP synthase subunit H 	Finn RD	anon	Pfam-B_3341 (release 8.0)	Family	ATP synthase subunit H is an extremely hydrophobic  of approximately 9 kDa [1].  This subunit may be required for assembly of vacuolar  ATPase [1]. 	25.00	25.00	28.40	28.40	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.34	0.72	-3.90	34	346	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	230	0	214	332	0	64.60	36	75.96	CHANGED	hslllsolhashhuhhu.hhsPK............u.spsllpshllLou.ssCaLhWhlsaLAQhsPLluPphsspp	...................h.slllholha...shl...G..hhss....hhsPK........................GsspsllpshLl.lTu.lCCaLhWhlsaLAQhNPLluPplpp.........................	0	74	113	167
+5322	PF05494	Tol_Tol_Ttg2		Toluene tolerance, Ttg2 	Finn RD	anon	Pfam-B_3575 (release 8.0)	Family	Toluene tolerance is mediated by increased cell membrane rigidity  resulting from changes in fatty acid and phospholipid compositions,  exclusion of toluene from the cell membrane, and removal of intracellular  toluene by degradation [1].  Many proteins are involved in these processes.  This family is a transporter which shows similarity  to ABC transporters [2].	21.50	21.50	21.80	25.20	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.92	0.71	-4.70	160	1882	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	1658	1	420	1153	1732	167.90	28	80.72	CHANGED	lppssscllshlpsspsth.......pth.....hphlcphltshhDhpthuphslG.p.......a.............+.psospQ+.....ppFhptFcphLhpoYu.stlspas..s........pp..lpht..thpss.....ppshVpoplhpsss...pslplsaplpp.....tss.p..W+laDlhlp...G.lSllpshRspFsshlppp.G.l-sLlpp.......Lppcs	............................ppsspcshspL+sppsph.ptss...shlpslVcpplhPalshchhutllLGph...a.............+.pAoPtQp........ptahpuFcphLhpsYu.psLs..Yp..s........Qs......hplt....hs........stshsslcssllssss...sslpl-aphpc......psG.s..WpsYDhhsE...G..lShlsohp.spaushlcpp.G..lDuLhtpLcp..h......................	0	114	234	328
+5323	PF05495	zf-CHY		CHY zinc finger	Wood V, Bateman A, Mistry J	anon	Pfam-B_5537 (release 7.8)	Domain	This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues. We have named this domain after the N-terminal motif CXHY. This domain can be found in isolation in some proteins, but is also often associated with Pfam:PF00097.  One of the proteins in this family (Swiss:P36078) is a mitochondrial intermembrane space protein called Hot13. This protein is involved in the assembly of small TIM complexes [1].	23.30	23.30	23.30	23.60	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.78	0.72	-3.82	76	971	2009-01-15 18:05:59	2003-04-07 12:59:11	7	24	596	2	499	817	15	75.40	32	23.00	CHANGED	CpHYcps...stl+ssCC..scaYsCt................pCHc-tp.........sHphpRhs.p........tllCshCppt..shsph.............tss.....phhCshCp........ha.	........................CpHYcpp...stl+ssCC..s+..a......Y.sCh................pCH.sc..t.p......................................cH.sh...p+hshp...................tllCuhCppp.shsph...........................tps..............hCshCphh.................................................................................................	0	165	308	434
+5324	PF05496	RuvB_N		Holliday junction DNA helicase ruvB N-terminus	Moxon SJ	anon	Pfam-B_844 (release 8.0)	Family	The RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein [1]. This family contains the N-terminal region of the protein. 	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.40	0.70	-5.32	110	5721	2012-10-05 12:31:08	2003-04-07 12:59:11	7	23	4390	12	1243	22353	7697	210.90	46	58.50	CHANGED	Rl.lssp....tttp.....-....pshEtuLRPppLs-alGQcclKcpLplaIpAA+pRsEuLDHVLLaGPPGLGKTTLApIIAsEhGVsl+hTSGPslE+sGDLAAlLTsLpssDVLFIDEIHRLspsVEElLYPAMEDaplDIlIGcGPuARol+l-LP.FTLVGATTRuGhLouPLRDRFGlhtRL-FYss--LppIlpRoAclLslslss-GAtEIA+RSRGTPRIANRLLRRVRDaApVcuc	.............................................................................h..............-..p..h-..ps.L..R...P........p....p....L....c.....-....a.....l.....G.Q...p....c.l...+....p........p......l.....c........l....a........I.............c............A............A...........+........h............R................s............-................s...............L............D..................H..............l...........L..l....a.G.P.PGLGK...TTL..A.....p........I....I...A...s...........E.......h..........G........l........s............l..........+............p........T..........S...............G..........P...........s.......l............-...............+..............s..............G..............D..........L................A..............A...............l............L............o..........s..........L..........p......................t..............D.............V...........L........F...........I.D...........E.....I.....H......R.....L...s...................s...............l......E..........E...........l...........L....Y..P...A........M......E....D.......a.............p....l.......D......I.....h......I.....G......p.......G.......s.......u...A.....+...o...l........+......l....-........L............s...................F......T..L..l.G..A.....T....T.....R......u..G............L...o..sP..L....R..D..RFG..l..h...+h-.a..Y..p.....t..-....L...ptI..l.t.....R...o...A.t..h..h...t...h...t........h...pt...p.u.A....hE.lA....pR.uR..G.TP..R.I.AN....RLL+RVRDaApVpts.......................................................................................................................................................................	0	440	849	1068
+5325	PF05497	Destabilase		Destabilase	Finn RD	anon	Pfam-B_4147 (release 8.0)	Family	Destabilase is an endo-epsilon(gamma-Glu)-Lys isopeptidase, which cleaves  isopeptide bonds formed by transglutaminase (Factor XIIIa) between  glutamine gamma-carboxamide and the epsilon-amino group of lysine [1].	26.20	26.20	26.40	28.10	25.30	26.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.35	0.71	-4.01	28	193	2009-09-11 15:14:13	2003-04-07 12:59:11	7	4	73	4	107	201	1	109.90	35	68.13	CHANGED	lossCLpCICcspS.GC.tsls.CchD.h.p.uCGhFpIppuYWhDsG+...PGss........apsCusDhsCusssVpsYMp+Yt....psCsss....CcsaARlHsGGPpGCc.....ps.shsYhpplppphs	......................sptCLtClCpstS.GCptshh.Cp.s.......sCGhFpIohsYWhDuGc......sscs.....tt..uapsCss..D.pCAspsVpsYMp+as..pcCssct..sCpDautlHphGshGCp.....s.p..h.s..h..tY.phhppCh.p...................	0	43	56	93
+5326	PF05498	RALF		Rapid ALkalinization Factor (RALF) 	Finn RD	anon	Pfam-B_4453 (release 8.0)	Family	RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root  growth and development [1].	21.30	21.30	21.30	22.00	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.46	0.72	-3.15	34	313	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	35	0	202	290	0	64.10	36	55.35	CHANGED	tttt.shhsu.sspRhhttp......pYIS.YsALc+splPCs.pcGsoYY..sC.cssspANPYsRGCSsITRC+c	.......................s.........s..tpRhlttt.........pYIS.YuA.Lp+s.plPCs..ppGs.SYY...NC.ps.s..........stANPYsR..GCotITRCRt..............	0	40	107	152
+5327	PF05499	DMAP1		DNA methyltransferase 1-associated protein 1 (DMAP1)	Moxon SJ	anon	Pfam-B_38340 (release 8.0)	Family	DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication [1].	25.00	25.00	25.00	25.30	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.72	6	129	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	103	0	88	119	0	152.70	44	34.72	CHANGED	EEEhLlsELRKIEsRKKEREKKsQDLQKLIotAD..........oTuptR.KpEKKhhKK..Klspp.ts.+pspclsVsE..ouGIKFsDhKuuGVoLRSQ+MKLPusVGQKKlKAlEQhLpEhtVDhsPsPTE-IsphFNELRSDhVLLhELKpAhusCEaEhpoL+H+aEALs.GKslshP	...........................................EEphLltEL+KIEtRKKERE++sQDLQKLIotAD.......................sssp.R....+.tE++h.KK.......Kls.p.p.........+p.s....pt.ssss-.............suGIKFsD.h.+uuGVpLRSQ+M.....K.....LPu...ulGQKKlKulEQhL.pE.luV.-.............LsP.sPTE-lsp.FNELRSDlVLLhEL+pAhusCEaElp.LRHpaEAhs.utsh...t.................	0	29	39	66
+5329	PF05501	DUF755		Domain of unknown function (DUF755) 	Finn RD	anon	Pfam-B_4891 (release 8.0)	Family	This family is predominated by ORFs from Circoviridae. The function of this family remains to be determined.	29.10	29.10	30.00	39.50	29.00	29.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.77	0.71	-4.06	21	74	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	29	0	0	75	0	125.50	27	50.26	CHANGED	ps.cpshhsPIsSpKQYKLtsQppps.ptssTsGTo-sshLpppLLKECpKTupLhpL.ppl..............ppccpppsspspp+++K+p+psStppuKKhpsK++.......tpssSSSSSSssuoSSSppSS	.........pph.tPlsShcpYK.hTppsps.pssSTsGTs-sssLtppLLKECppTppLh.phh.ppltpp.............ttpp....pp....ppps...s...ppppccpp.+p+phstp..pt++.ppp+++............pppsSSSSSSssssoosppo.s.....................	0	0	0	0
+5330	PF05502	Dynactin_p62		Dynactin p62 family	Finn RD	anon	Pfam-B_4912 (release 8.0)	Family	Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin [1,2].	22.90	22.90	23.20	22.90	22.10	22.80	hmmbuild  -o /dev/null HMM SEED	483	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.84	0.70	-5.73	11	399	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	215	0	284	414	0	252.30	19	75.82	CHANGED	P.EpLlaCEDCHQIKCPRCloEEIssaYCPsCLFEoPSStlR.EtN....RCARNCFsCPhCsuPLuVssl-s...........ssuussppGPasLoCuYChWoohDlGlpF-KPssIphQLuK.....................hp....t....su+tht......-h+pshSoauoh-s............tpts...pp.sssLsh-s+FssLKuFYKsQlusssoussD.hth.chus....uFuuPs..uLsRhMslYsuuupl.shhs.spKKs+s+P.s.hR-ALssoEGLpl..ts.sEsshIpphss.......puasulASl-QhhhQ.sPss.........RFsE-LLPlPVLLRTKRSKRCcsC+HILlKPEhKspSsRFRI+LlAlsYIP..sl+...............................sL..ss...............s...s.sssslcsLpPh+shQllLTlKNhhF-PV+VTLuTPusT.PGRluoK...VTlLCPpF-IsuNpDsWpEALp............................hssus.c.uS+uushshst-+ssEuGKVW-+GRNWTolVLEVVPuoLs.......sttssp.phppccDs	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	99	143	231
+5331	PF05503	Pox_G7		Poxvirus G7-like 	Finn RD	anon	Pfam-B_4957 (release 8.0)	Family	\N	20.00	20.00	20.10	100.60	19.80	17.00	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.08	0.70	-5.85	11	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	42	0	0	50	0	356.90	62	98.52	CHANGED	MtEt..KQS.....pIFsIloKullpSls+sh..shsssYIpuKAKpLhYssssoh+-ulINuIYspsEssIslsshscLhclLspL+ppusYVsNssEFWRLYNSLhRFTHspSFFssChPTIlsTLATLlTLlLuNcLLaAA-MVEulEsYLFs.upKs.uQELADLL-MKYGLINLVQYKIhPlllGppt......p..hhuu..uuss.ssassEl-+LhELPVKoshlsplYcFLsc+GlsToNNaAEYlAGLKIEElsp...........................tss.t...t.s..sht.ppptshtthc............lLcpApKYSKGHVLDGuVoSPlTtpt.lsspIP..............hosoDlcKFsILEYLYlMRVhANsIK+Ks..tpspsp.GIsLsINS.PFKoITlPus	.........t.tEQ..RpS.....TIFDIVSKsIVpSVLRDI..SINoEYIESKAKQLCYC.suSKKESVINGIYNCCESNIcIhD+EpLLKILDNLRsHSsHVCNuoDFWRLYNSL+RFTHTTuFFNTC+PTIlATLsTLITLILSNKLLYAAEMVEYlENpLsS.SNKSMSQELA-LLEMKYALINLVQYRILPMIIGEs..........IIlAGhsGKpPhS-YSuEVERLMELPVKTDIVsssYDFLuRKGIcTSNNlAEYIAGLKIEElpKspphhs................shushANSshlKs+K...SIhPA..NIND+pIMEso+............hLDsuEKYSKGacsDGAVTSPLTuNsT.IooaIP..............ISASDMQKFTILEYLYIMRVMANNVKKKN...EuKNsGGVVhpINS.PFKlIslPp.s....	0	0	0	0
+5332	PF05504	Spore_GerAC		Spore germination B3/ GerAC like, C-terminal 	Finn RD	anon	Pfam-B_5052 (release 8.0)	Family	The GerAC protein of the Bacillus subtilis spore is required for the  germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the  germination apparatus that respond directly to this germinant,  mediating the spore's response [1].	21.30	21.30	21.40	21.40	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-10.82	0.71	-4.48	137	1584	2009-09-10 14:51:44	2003-04-07 12:59:11	6	5	321	1	349	1395	6	166.40	21	45.64	CHANGED	lsGsAlF.+s..cKhlu.hLstp-spshphlpschps.Ghlslphsppt................................................hlsh.plhpsc.sclcsph.cssch.p...hpl..plphcupltEhp.sths..h.s....tchlpplEcthpcplccphpphl.cchQ.chpsDshGhGchh+p..phscha.p.h.ppcW..p...ch.aspspl.clpVclpIppsGhhp	....................................sGhAlh..+s...sKhhu.hLstc-shshphlp..sc.hp......t..uhhp.hp.h.spst................................................hlsh..ph.h.psc...sclcsph..pss..p..phpl...clphcupltEht..pshs....h.p.....cphcplcctlpcplccchpphl.c.phQ.chpsDshGhGchh+p..pp.chW.p.h...pcpW....p.....ph..as...cs.pl.plplclpIppsGh..p..................................	4	178	289	304
+5333	PF05505	Ebola_NP		Ebola nucleoprotein	Moxon SJ	anon	Pfam-B_8475 (release 8.0)	Family	This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus [1].	25.00	25.00	186.20	186.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.16	0.70	-6.46	4	104	2012-10-01 19:59:50	2003-04-07 12:59:11	7	1	21	0	0	58	0	391.30	83	98.86	CHANGED	hDYHKILTAGLoVQQGIVRQ+lIsVY.VNsLEuICQhIIQAFEAGlDFQ-sADSFLLhLCLHHAYQGDa+LFLcSsAVpYLEGHGF+FEV+K+-sVpRL-ELLPssouGKNl+RTLAAhPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTuWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDuVISNSVAQARFSGLLIVKTVLDHILQKTDpGVRLHPLARTAKVKNEVsSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAEoRELDsLGLDDQE+KILMsFHQKKNEISFQQTNAMVTLRKERLAKLTEAIT.........tASps+lus+asDDs-IPFPGPIpssspss..-DsPpDSRDTsIPssVlDP.Ds-.spYsuYp-sthssssDLsLFsLD-D-.DDo+shP........ptsp..Gpps.phpsh.+PP...PGspps.p.+tStshsssspppt..............PptspusRh..LoPlpEEs-s.DpsDs-spSLssLES-D-.....EQs.Dhot.....VAPPAPVY+s.tctctlspsppNs.spTsphtsp-uDh......sSpsppshEETYhHlL+oQGPF-AlNYYHhMpDEPlhFSTccGKEYhYPDSLEEsYPPWLoEKEtl-cENRalslcsQQFhWPVMSh+-KFhAl	..........................................................................................................................................................................................................................VuQsRFSGLLIVKTVLEFILQKTDSGVsLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAp-AEhpLQ+htEppElpulu.DDpERKILcpFH.p................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+5334	PF05506	DUF756		Domain of unknown function (DUF756)	Yeats C	anon	Yeats C	Domain	This domain is found, normally as a tandem repeat, at the C-terminus of bacterial phospholipase C proteins.	24.40	24.40	24.80	24.40	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.08	0.72	-3.50	86	1055	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	296	0	344	1014	25	89.40	29	23.80	CHANGED	su+AlPYp.clpsphcsuss.plpLph..sN...s......G..psuu.......sFpVhs....pt.t.....h.s........stP.............................cpYsVpu...........Gpp.lpspW..sh.ssssGhYDLtVhG....PsG..FhR+FsGc	......................................................................ttshshp.cl...ps.....p.hc.....ss....s.....u....slpLph...sN......s.........G......pt..us.......sap.Vhs.........tt.h.....t.t.................stP..................................................................t.p.a.sVpu...........Gpp...lps..p.W...sh...sss...suhYD..l..s..Vpu.....ssG....FhR+FsGc...............	0	78	159	274
+5335	PF05507	MAGP		Microfibril-associated glycoprotein (MAGP)	Moxon SJ	anon	Pfam-B_8462 (release 8.0)	Family	This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils [1]. 	28.00	28.00	29.60	40.60	22.50	27.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.86	0.71	-4.36	4	107	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	40	0	49	96	0	120.30	53	77.79	CHANGED	hhhGsKsLLhLsAhllsSshhPLGVsuQRGDDVp.spsETFTEDPNLVN....DPuTDET.........VLADItPSTDDLAu......s-KNsTsECRDEKFsCTRLYSVHRPlKQClHQlCFTSLRRMYllNpEICSRLVCKEHEAMKDE	.......................................................hs.hhLLhh..h.lsp.t.h.lts.s.hsDpl...p.ps.h-sP.sh.h.s...............sPtsspp...............tl.t-...l...h..Pusss..ss........sscsssh....-CR-EpasCTRLYSVH+PsKQClpp.lCFhSLRRhYllNKEICsRhVCtccEhh+s-...........	0	3	7	16
+5336	PF05508	Ran-binding		RanGTP-binding protein	Wood V	anon	Pfam-B_37054 (release 8.0)	Family	The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The S. cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins [1].	25.00	25.00	39.90	25.40	22.10	24.00	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.79	0.70	-5.53	18	126	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	112	0	95	128	0	299.00	40	58.01	CHANGED	MDplLu+susQAVoF....AIRSGIolASsYAl+pso+aLcplsps-p......pclcpl+p+LcoKIcIlSsAIDLIcLhuAR..........GNTsLEuslsLscsL+t-IspFsp+lsphspt..............spsspspccslppl.cthKcLLsRI--AlPLlNLulTTSGsslsosL.....ssslSPuRLLQASsalsp..............................usspasts.p............slQlGPoFsLohYslFhs.s.+.t.........................-u.pplsWKEsht+upl+lhRh....................................scpscYuYpLcIhEDasDGRYH---..............tshphplslppIs+lFFosSGKLLplpsp....soPVLlLKhsps.ts	........MDthLs...+hspQAhsa....AIRSGIulsusYAlpphophlp...................p............lstppt......pclppLptcLps+IpIlSsAIDhIcLhAAR..........GNTsL.........ESsltLs+sL+.-Ipphsp+lsphsp..p............spsppppctplptl.ptl+pLLtRI--slPLlNLulTTSGssLoosL.....PsslSPuRLLQASsalot..................................................usppas.s.pp...........slQlGPoFsLolYhlFhshs.p...t................................................-u.ppssWKEsh++A+l+lhRhs...................................uptsca.....uYplhIhEDhDDGRhHs.-t............h..ssh+chlslppIsKlFausoGKlLpltsp....ssPVLlLKhDhp.h..............................................	0	18	46	79
+5337	PF05509	TraY		TraY domain	Moxon SJ, Bateman A	anon	Pfam-B_8963 (release 8.0)	Domain	This family consists of several enterobacterial TraY proteins. TraY is involved in bacterial conjugation where it is required for efficient nick formation in the F plasmid [1]. These proteins have a ribbon-helix-helix fold and are likely to be DNA-binding proteins.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.04	0.72	-4.19	28	257	2012-10-02 18:44:02	2003-04-07 12:59:11	6	3	175	0	28	195	6	48.00	45	68.00	CHANGED	lhlpLcpcsNchL.putc+SGRSKppEAtlRLpDHLpcFschhpsphpt	..........hpLD--TNphLltApsRSGRoKThEsthRLpDHLp+FPDFYstEh..p...................	0	4	9	15
+5338	PF05510	Sarcoglycan_2	sarcoglycan_2; 	Sarcoglycan alpha/epsilon	Moxon SJ	anon	Pfam-B_9181 (release 8.0)	Family	Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear [1]. This family contains alpha and epsilon members.	27.00	27.00	27.20	28.10	25.60	24.30	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.25	0.70	-6.16	5	222	2009-09-12 20:59:17	2003-04-07 12:59:11	8	3	82	0	95	170	0	320.00	44	91.77	CHANGED	stlhLLs..hhulLstspSs+ht......TlploVGcLFsHpLEschF....sasscssopp...loY+soLcGYPDLPsWLRYpQcssY+sGFLYGSPTscsAGp.lsIEITAaNRcoFET+RpcLhLsIscsps..LPYQAEFpI+NhNl-chLsospl-sF+stl+s.LWptsPc-LpVlNl-SALDRGGRVPLPPp.pKEGVaV+VGSsspFSopL+El...VpP..pl.uCoQcpsPVtosa-shhopF+lDWCsFpLV-Los.........pssp-ppshp.stG-GhLacDsaauPPs-clscRDYhs-FlloLAlPuhIsLlLhllLuhIMCFpREGhhc+cpc.................ssclQhsHHSuIp.......+SThcLRpMAcsp-lshPLoTLsSacshsu.............-R.PP.spcpsDsTsMPhhpssp	......................................................................h...........slh.t...tssp.........slhs.sGhlFVHsL-p.chF...........h.s.s.sp...........lTapssL.GaPDhPtWLRYhQRosapsGhLYGoPTs-shG+.plIElsAYNRcoF-TsRppLllp..Ihs.s...E...t....LPYQAEFhl+shsVEEhLs..S..pshscF.LsAlps.lWp....PtcLphlNITS..ALDRGGRVP....LPIp...shKEGVYlhVGusssFSsCL+.l.....sPtpph..pCs..p..t.tsllss.cph..hspFhlDWCplsL...V-hsh.........................ss.p.sh.................Gp.GlL...cs..s.....apPPp-s..s..Rs...ahsD..h..llTl.hlP...hlALlLhhlLualMCsRREGh..t.p..t....................................ss.tIQhlHHssIp.......tsTcELRpMu..tsRclsh.PLSTLPhFpshoG.............EhhPP.....ph-ssphPhh.sp.....................................................	0	20	27	57
+5339	PF05511	ATP-synt_F6		Mitochondrial ATP synthase coupling factor 6	Moxon SJ	anon	Pfam-B_9347 (release 8.0)	Family	Coupling factor 6 (F6) is a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments [1]. 	27.90	27.90	28.50	31.60	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.32	0.72	-4.10	17	159	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	102	5	80	157	0	92.10	42	71.49	CHANGED	Mhh.....phsthhtssholphRRNlGlo.Ashhs..KthDPIQpLFlDKlREY..KppsoGG.hVDAuPEhp+-LpcElpKLpphYGGu...DMspFPpFKFp-	...............................................h.phhshth.+RN.luho.Ashhs...Kt....hDPIQ+LFlDKIREYpsKppu.uG.G...VDuuP-ap+-LpcELpKLpphYGsu.....DhspFPpFKFp-..........	0	25	33	56
+5340	PF05512	AWPM-19		AWPM-19-like family	Finn RD	anon	Pfam-B_6960 (release 8.0)	Family	Members of this family are 19 kDa membrane proteins. The levels of the plant protein AWPM-19 increase dramatically when there is an increase level of abscisic acid.  The increase presence of this protein leads to greater tolerance of freezing [1].	19.90	19.90	20.70	20.50	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.77	0.71	-4.19	12	134	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	29	0	80	129	1	126.30	45	74.10	CHANGED	hLNLsMYlllluluuWulN+tI.s.Ghp.tsuhu....h.Phah..GNsATGFFl.hFullAGVVGsASsLsGhpH....lRsWpspSLsuAAouuhlAWuLThLAMGLACKEIp.......lGt.RshRL......RshEAFhIILohTQLLYlhulHuGh	.............................hLNhsMYlIlhuluuWulN+tI.s....uh..tsshs.....................GNsATsaFl.hFuLlAGVVGhAS.slsGhpH....lRs.WpscSLsuAuusuhlAWsLTlLAhGlACKEIp.......lut..Rst+L..................+slEAFhIILuhTQLhYllhlHuG.h...........	1	15	51	67
+5341	PF05513	TraA		TraA	Moxon SJ	anon	Pfam-B_9521 (release 8.0)	Family	Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response [1].	21.30	21.30	21.30	21.40	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.58	0.71	-3.94	2	236	2009-09-11 07:37:51	2003-04-07 12:59:11	6	2	185	0	14	133	1	112.60	63	97.55	CHANGED	MNhshuhtGhsAPVKp+ua.asphshhshhphtthsh.AAl..hhh.tlu.hApupDLhAuGpssVKATFGtDS.VhhhlllAEllVGssMYhhTKNlhhLhGhsll.VFhsVGhshlt	..........................MsslLSVQGASAPVcKK.SF.FSK.F.TR...........LNMLRLs.R.AVIPAAV.L.MMF...FPpL..A.......MAA..p...G.pDLMASG.NsTVKATFGKDSSVVKWVVLAEVLVGAVMYMMTKN.V.K.F.LuGFAIISVFIAVGMuVVG.....................	0	0	1	10
+5342	PF05514	HR_lesion		HR-like lesion-inducing 	Finn RD	anon	Pfam-B_6954 (release 8.0)	Family	Family of plant proteins that are associated with the hypersensitive response (HR) pathway of defence against  plant pathogens [1].	22.60	22.60	22.60	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.65	0.71	-4.35	10	108	2012-10-02 13:32:46	2003-04-07 12:59:11	6	3	32	0	56	176	63	133.20	48	77.07	CHANGED	MuFlSFlGRVLFASlFlLSAaQEFsEF..GsDGGPAAKsLpPKaNhhssplosph....GhtVPpl-lKplVAAsIuLKGlGGLLFIaGSShGAYLLLlY.AhsTPllYDFYNYch-c.............................................................s-FspLFh+FsQsLALlGALLFFlGM	...................................................MuFhSFhGRVLFASlFlLS.AaQcFsEF..G.s..DG..G.PA.A..KtLp.P.K.h.sl.h.p.p.plo.spl....Gh.t...l..P.c.............l..-...lKp..llA.us..I.s..LKGlGGl...LF...l...hu..S.o..h..G..AaLLL.l..aLuh.h.TPI..l.YDFYN.Y.c.h.-.p............................................................scFspLhhcFhQNlALhG.A..LLFFlGM.........................	0	11	36	47
+5343	PF05515	Viral_NABP		Viral nucleic acid binding 	Finn RD	anon	Pfam-B_6916 (release 8.0)	Family	This family is common to ssRNA positive-strand viruses and are commonly described as nucleic acid binding  proteins (NABP).	21.50	21.50	21.50	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-3.85	8	209	2012-10-01 20:03:16	2003-04-07 12:59:11	6	2	29	0	0	374	1	97.30	38	84.68	CHANGED	MHPaDFN................................LLC.....................................CLH..............................FS+PsLPpDL+lhIastsssspKLsR+sppNKPFpGTSKCAtRRRAKRYNRCFDCGA..aLhcsHsCK..lFsSRApSDsLuVIHEGPAKLYAERoaR.NScAtQLItsDL.hhK	............................................................................................................................................................................................................................................a.p.GpS+sAtRRRA+RYsRCacCGu.......hhhss+.C+..hhsotups-sLtsI+cGss+LhuEp.................................................	0	0	0	0
+5345	PF05517	p25-alpha		p25-alpha 	Finn RD	anon	Pfam-B_6873 (release 8.0)	Family	This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase [1].  It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.33	0.71	-3.97	24	380	2009-01-15 18:05:59	2003-04-07 12:59:11	7	17	149	3	285	336	10	138.70	30	57.31	CHANGED	lcpsFcpFs.aG......pustp-Mcs+pFuKhhKDspll..spK.lTsTDsDllFuK..VKupss++.IsappF.ccuLsplApK+tt........pspplhpclh..tutuPthsu....spussVchhsDpopYTGsHKpths..soscsp..GhuGhtphsDco.........ptsshshph	.............................................................pp.FptFs.aG..........pusspphssppasKhh+Ds..tlh............Ds+...lTsTDsDllFsK.......l....K......u..+..ssc......p...Is..app..F..pcAl.p.c.lApc+ht........................ph.phhtplh.....tstsPthsu.......................ttsssspphsDpopYTGsHKpphs..tsscsp..uhuGh.phh-tp..................t.s......h................................................	0	115	149	205
+5346	PF05518	Totivirus_coat		Totivirus coat protein	Moxon SJ	anon	Pfam-B_10221 (release 8.0)	Family	\N	25.00	25.00	34.70	34.60	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	759	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.20	0.70	-6.70	7	23	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	20	0	0	24	0	622.50	31	97.28	CHANGED	LsuslssstuGshhss............ssaR+YcAtlphpusstGshpushssIaaElGt+ht........+sscshtssstpuhhl-suhs.sss.stsa.shsR+aps.......huspahhhslsullc+lutslAshslhssh.hsstuh+tspshpVsuLuohDu.psussuuV..alPpslc.shssclFslLh.sAsupGusVssDslpLDusTspPhlPslsssshttAhs.sLpllGu.MpuustGshaAhALTpGlHsVloVVuHoDEGGhhRDlLRpstap.PaGGlshuLp...pasulsshspsuhushsuhsDulALsTAAlVAHCDPh..hssshaPTlhssphsssst.ssu.........t...ttpltushs+FuphYhcuLuhhFultuss.thsspplhpAusphlstssp...RHLchsosAPaFWlEPTuLls.hshhGosAEttGYuuhshh.GssRopPsa-shchhGptsos.assaphchposRosshlshhss+PtsGLushcltphsssullLsG............ssssssstc+ttutssls-YlWtRGQoshPtPAEhhNhsuthslphRhhsas-Dtsss..pchPssc-hhcssVThpsst.hslssuspNstssts+RuRstuuptLsp....ARshGhssssph.Its.sPs.tss...st.shspsspsussspssss.sthsstshtssp.u.RGsPltssspHtshRAP.hsR...s.tGssshs.....s.ssss.s......................s.s..sssssss..hssssptsssstsp	....LsuslssspuGphhss............spaR+YcAslphsushtGshpsp.ptIhaElGtths........pttphht...ttuh.l-suhshsss.utpF.GhA++aoN.......Fuspa.h.slsuhsERlu+slAshslhss.....hs.sshttstshhVsuLuThDuP.su.tsuV..aIPRhlssshssclFsVLhtAssGpGuslsoDhlcLDsssppPhlPtlsssshstAhstALRllGuNM.sustGslFuhAlsRGlHpsloVVuHoDEGGhhRslLRpstFtsPaGGlp.uLp....asuLPshsssu.sshuuaVDulALtTAAhVAHsDPhh.hsGshaPThhsustssss.stsst...ss...stt.ttQlhushstFs..YhcuLutlFGhtsss...sttphhsshshhLstss....RHLchtoluPaFWlEPToLls.hshhGosAEttGhuuhsh..ssstshPsa-phphhupssss.aushthchposRpsshhstatspP.suLuslclcQhDssullhsG............sssps.sltc+htAssPlosYLWsRGQSshPAPuEhlNhsushGhhlRhhsas.--hsss..pclPsscEhhpssVohcVstPtGLs.sGssNttsppA+RARo+AsttLupuhhRARsaGtsssspM.l.sssPshts......t.thtphsttsh..st..t.s.shh.sts..s.t.s.pssPh.ss.ppts.chP.hst.hss..us.us.hss.s.s..s.sss.s..................................................t.................................................	0	0	0	0
+5348	PF05520	Citrus_P18		Citrus tristeza virus P18 protein	Moxon SJ	anon	Pfam-B_10309 (release 8.0)	Family	\N	25.00	25.00	249.60	249.50	17.30	17.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.04	0.71	-4.75	3	112	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1	0	0	101	0	151.10	95	100.00	CHANGED	MSGSLGNSTHVDLLRSDSRFLSGWWSFIVNVGDIIVRFALHVPSEDMLNSFSAISNCTIIADGSALLKDNTVVDRLESMNPLAYLLKLAKTTTTICFTMSNKVLFGTTKSEPLSCLAITSDRVLFKVIMGTNVDDSRCGCSIWFYNNGTFQNGLTRCNNLVALFSAT	.........THVDLLRSDSRFLSGWWSFIVNVGDIIVRFALHVPsEDMLNSFSAISNCTIIADGSALLKDNTVVDRLESMNPLAYLLKLAKTTTTICFTMSNKVLFGTTKSEPLSCLAITSDRVLFKVIMGTNVDDSRCGCSIWFYNNGTFQNGLTRCNNLV........	0	0	0	0
+5349	PF05521	Phage_H_T_join		Phage head-tail joining protein 	Finn RD	anon	Pfam-B_7008 (release 8.0)	Family	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.43	0.72	-3.70	131	1460	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	1110	2	227	1023	107	96.10	18	85.37	CHANGED	s+Rlslp........ts.ps..p-....s..sGshh....ts.a........tsht..s.lWAplp...sh..supEh.htussstup...h...shplplRa.ps.....sl....ssshR....lh......h.s....schapIpu....lschs.ptp.hlplhs	..........................................p+lph...t....h....tt..ps....s....sGthh.......pp.a........ht.hh........p..saAplp.......sh.....sup-h.....hpu.....ssp.tsp...s........shplhlRh..pp.........cl..........os.sh+...lt...........a..p..............sphasIts...lpssst.ppp.hl.lh......................................................	0	64	140	186
+5350	PF05522	Metallothio_6	Metallothionein;	Metallothionein	Moxon SJ	anon	Pfam-B_1360 (release 8.0)	Family	This family consists of metallothioneins from several worm and sea urchin species. Metallothioneins are low molecular weight, cysteine rich proteins known to be involved in heavy metal detoxification and homeostasis [1].	20.90	20.90	27.80	23.90	17.70	19.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.22	0.72	-10.69	0.72	-3.70	7	30	2012-10-05 18:33:37	2003-04-07 12:59:11	6	1	19	2	5	34	0	66.20	52	80.30	CHANGED	sssKssCs+-GppCsC.upppClpucCs.sscplCCu.....pCuNAuCKCusuCKCuuG...suCpcGsCss	......ssspssCs+EGppCsC.upCpChpu-Cs.ssccsCCu.......sKCGNAuCK.CGuuCKCuuG....suCscG.sCss..........	0	5	5	5
+5351	PF05523	FdtA	WxcM_C; 	WxcM-like, C-terminal 	Finn RD, Studholme DJ, Andreas P	anon	Pfam-B_6950 (release 8.0)	Family	This family includes FdtA (Swiss:Q6T1W8) from Aneurinibacillus thermoaerophilus, which has been characterised as a dtdp-6-deoxy-3,4-keto-hexulose isomerase [1]. It also includes WxcM (Swiss:Q93S92) from Xanthomonas campestris (pv. campestris) [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.58	0.71	-4.64	64	624	2012-10-10 13:59:34	2003-04-07 12:59:11	6	12	477	8	145	730	885	125.10	29	67.10	CHANGED	hss.p..llclspl....sD..RG....sLoslEtt.pp..lPFcIKRlYYlacVPsstt.RGtHAH+chcQhllslsGShclh.........LDDGpp+..pphhLscPt.hGLalsshlW+phhsFSss.uVhLVLASchYDEsDYIR-YspF.lphhp	.........................................thlph.th......tDt..+G....p.L.s...h.h...-t....p......l..P.F..p.lcRl.a.a.l.ass....su.hs...RG.tHAH.....+...p...hp.phhlsl.p.GS..h.p...lh.................................l..-..-...Gp..sp........pph......h..L...s...pss...pG.....L...h....lsshhW+phpsF.S..s.s..s..l.l.l..V.lA...schY-c..p-Y.IhsYp.aht...t........................................................	0	52	109	131
+5352	PF05524	PEP-utilisers_N		PEP-utilising enzyme, N-terminal	Finn RD, Studholme DJ	anon	Pfam-B_69291 (release 8.0)	Family	\N	21.90	21.90	21.90	22.60	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.29	0.71	-4.32	186	5872	2009-01-15 18:05:59	2003-04-07 12:59:11	8	34	3547	22	1028	3717	559	122.50	27	19.06	CHANGED	lpGlusSsGlAlGpshhhp....ttt..hphsppts.....tshpt.EhpR..hcpAlppsppcL.p..pltpp....h.tth....................s.....sspu.s.IhcuahhlLpDspLhpplpptIppsp.sAphAlppshpphtphhpshsDt.Yl+ERu	..................................pGlsuusGlAlGcu.hhltpsp..........hshpptsh..........pssst.EhpR.lpsAlppstppL.p.plpp+....h.tph..........................s....p-pu..u.IF-uHhhlLsDscL.hpplpph...I.pppp..sA-tAlppshcphsstapph.s..Dp..YL+ERA.............	0	310	592	817
+5353	PF05525	Branch_AA_trans		Branched-chain amino acid transport protein	Moxon SJ	anon	Pfam-B_1869 (release 8.0)	Family	This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force [1].	22.30	22.30	22.60	22.50	21.50	22.20	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.49	0.70	-5.90	21	3775	2012-10-03 01:44:59	2003-04-07 12:59:11	8	4	2395	0	374	2332	41	418.00	37	96.77	CHANGED	pp+-hlhlGhMLFulFFGAGNLIFPPhLGhtuGpshhhAhlGFllTuVGLPlLulluluhsGt.ulcslus+ls.hauhlassllYLuIGPhaAlPRTusluFEhulsPhls....ssslsLhlaollaFulshhlSLpPuKllDplGKhLTPlLLlhlhlLhl.tulhpPhGshsss......p.stY.pspshhpGFl-GY.TMDsLAulsFGllIlsul+spGhp......sp+phhphslpuGlIAulhLullYsuLualGAsSsshh..........sssssGuplLsphspthFGshGpllLulllslACLTTulGLlousu-aFsclhP.tlSY+thshlholhShllANhGLspIIplSlPVLshlYPluIsLllLshhpphhpt..phsYpsslhhohlhull-ulpuhhhh........shlsphhphLPLtshGLuWLlPulluhlluhllsphp	.................................................................h..+chlhlGhMLFulFFGAGNLIFPPhLG.tAGpphahAhhGFllTuVGLPlLs.llAluh....s..ss.....ul.p.s.l....us....+ls.hauhl...as.sllY..LsIGPhFAl...PRTA.ol.oaElGlsPhhs................sp........sh.........s.........Lh.l.................FollF.FulshhloLpPuKllDplG+hLTPlhLlhlsllhl.tu.h.lp.P.h.......G..s.h..sss................s..ts.Y...ps..s..sFhpGFlpGY.TMDsLA.ulsFGlllVsul..+..pp......Gls....................ppppl.s+.hslh..uGllAulhLsllYhuL..salGupSs...shh...........stssNG.uhlLsphspphF.GshGp............llLuhllhlACLTTulGLlsAsu-aFpp.hh............P.....p....l.....S..Y.........+shlhlhs.lhShll.uNlGLsplIphSlPVLh.hlYPluIsLl.l..Ls.hh..p...p......hh...tp...p...p...h...s....a....t..h.s.hhhs......hlhu.lh-s....l.pss.s.h.........................shl.s.s.h..h.phLPLtphGluWllPulluhlluhlhs..h.................................	0	93	201	293
+5354	PF05526	R_equi_Vir		Rhodococcus equi virulence-associated protein	Moxon SJ	anon	Pfam-B_7324 (release 8.0)	Family	This family consists of several virulence-associated proteins from Rhodococcus equi. Rhodococcus equi is an important pulmonary pathogen of foals and is increasingly isolated from pneumonic infections and other infections in human immunodeficiency virus (HIV)-infected patients. Isolates from foals possess a large virulence plasmid, varying in size from 80 to 90 kb. Isolates lacking the plasmid are avirulent to foals. Little is known about the function of the plasmid apart from its encoding a virulence associated surface proteins [1].	25.00	25.00	31.80	31.70	22.50	17.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.08	0.71	-4.63	8	29	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	8	22	1	171.60	37	98.50	CHANGED	Mhchhh..su+sluustlsAsslh...APuGsAsApslssuusuus................susss.ththspssstshtstsssp-pQYsVHGsVsSAlVYQ+h+lsV-......sGcTF-GDAGGLohPGuuuhWGTLFTsDLQ+LYc-TVSFcYNAVGPYLNINFFDScGslLGHlQuGulSoVlG..IGGGoGuWc	.................................................................stthhs.hhsshshsh...sssGhAsAp.lssss.ss.................................sp...p.t..hspsssps.ttpsssp-ppYsV+GslsSAlhYQ+h..plpss......sGKsFsG-AGGlohPGuushaGTLF..TsDLp+LYs-TVSFpa.NAlGP.YLNINFFDupGslLGHlQuGulSTVsGlGGGoGuWp............	0	0	7	8
+5355	PF05527	DUF758		Domain of unknown function (DUF758) 	Finn RD	anon	Pfam-B_6320 (release 8.0)	Family	Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.	21.20	21.20	21.90	23.40	20.20	21.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.10	0.71	-4.68	14	241	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	96	1	145	222	0	178.10	50	91.04	CHANGED	h-sFsSKsLALQAQKKILSKMAoKohAphFIDDTSSElLDELYRloKEaTpN+pEApKllKsLIKlslKlGVLaRNsQFssEELtlspcF+KKl+psAMTAlSFaEV-aTFD+sVLuslLpECR-LL+plVppHLTsKSHGRIsHVFNHFuDs-hLssLYsPpusaRspLpKICsGlNKhL-EGsl	............-sFsSKsLALQAQKKlLSK.M.A.o....Kol.A.phh.I.DDTSSEl...L.DELYRl.oK......EaT.p.....s.....KKEAcKllKsLIKlslK.lulLaRNsQFst-.ELslh-+.F++Kl+..phAMTslSFap........V-aTFD..+....sVL....uplLpEC+-lL+plVp+HLTsKSHGRIscVFsHFuDs-FLssLYs...P.....ss.a+s.pLp+IC-GlNKhLDEtsl..............	0	31	43	77
+5356	PF05528	Coronavirus_5		Coronavirus gene 5 protein	Moxon SJ	anon	Pfam-B_7342 (release 8.0)	Family	Infectious bronchitis virus (IBV), a member of Coronaviridae family, has a single-stranded positive-sense RNA genome, which is 27 kb in length. Gene 5 contains two (5a and 5b) open reading frames. The function of the 5a and 5b proteins is unknown [1].	25.00	25.00	28.70	30.50	21.30	16.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.95	0.72	-4.16	2	99	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	13	0	0	100	0	80.40	87	99.62	CHANGED	MNNSK-NPFptAIARKARlYLREGLtCVYFLNcAGQAEsCPsCTSLV.pGphC-EHl.NNNLLSWpAV+.LE+QTPpRR.SN	.MNNSKDNPFRGAIARKARIYLR.EGLDCVYFLNKAGQAEPCPACTSLVFQGKTCEEHIsNNNLLSWQAVRQLE+QTPQRQSSN...............	0	0	0	0
+5357	PF05529	Bap31		B-cell receptor-associated protein 31-like 	Finn RD	anon	Pfam-B_6449 (release 8.0)	Family	Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8.  Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31 [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.22	0.71	-4.84	40	599	2009-09-11 14:14:48	2003-04-07 12:59:11	7	10	290	0	357	535	7	181.30	24	83.77	CHANGED	MoLhaoLVFshLhsEhshhhlLslPlPpslR.+plhphhttshhspphphshhhhlshlllLFlDulpRlh+hssphpttpsspssss..........sphp..u++FauQRNhYloGFoLFLoLllsRshollpcLlphpcphcshppptpttsttt.................................tppsttssElpcLKcclpp.......ccpDlcsLKcQscsLp+EY-	..........................................................................Msl.ashl.hhhLh.sEh.slhhlL.hl.Ph..shR....pplhp............hh..t.h..h..st..hhp..hhh..............hhlhshl.l..l...L.h..l.Dulp.c.hh+hssphp...tptpstss...............................h..p.h.h+hF.huQRNhYl..s..GFsLF.Lsl........l..lpRlh..sl..l....p....plhphpsp.hcshpppspst.t..pttt...........................................ttttt.tt-.htpLppclpt.....................tptch...sh..+pQsctlpp-ap...................................................................................	0	105	188	282
+5359	PF05531	NPV_P10		Nucleopolyhedrovirus P10 protein	Moxon SJ, Bateman A	anon	Pfam-B_7343 (release 8.0) & Pfam-B_6199 (release 10.0)	Family	This family consists of several nucleopolyhedrovirus P10 proteins which are thought to be involved in the morphogenesis of the polyhedra [1].	29.80	29.80	29.80	29.80	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.65	0.72	-3.73	21	81	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	63	0	3	70	0	77.80	37	77.83	CHANGED	MS..NILlhIRsDIpslssKVsuLQspV.......sslpsNlPshp.l.ttLDAQospLsslpo..............pVssIpsILs.................P-lPs	....MS..pNILhlIhscIpslssKVs.......uLQspV...........sslcssl....ss...l.tpL....Du.sspLsslps..............pVssIpslLs................hP-lP...........................................................................	0	0	1	1
+5360	PF05532	CsbD		CsbD-like	Finn RD	anon	Pfam-B_6755 (release 8.0)	Family	CsbD is a bacterial general stress response protein.  It's expression is mediated by sigma-B, an alternative sigma factor [1]. The role of CsbD in stress response is  unclear.	40.00	40.00	40.00	40.00	39.70	39.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.42	0.72	-4.29	119	3357	2012-10-02 00:15:32	2003-04-07 12:59:11	7	3	2275	2	706	1779	71	53.50	36	76.85	CHANGED	-clcGphcchpGcsKEshGchTsscphpsEGctcpstGcspcphucsK...-tscc	.........thcuphcphKGplKEshG+lTsDcphp.tEGct-pssGKsp-thspsK-psct..................	0	169	400	559
+5361	PF05533	Peptidase_C42		Beet yellows virus-type papain-like endopeptidase C42	Studholme DJ	anon	Merops	Domain	Members of the Closteroviridae and Potyviridae families of plant positive-strand RNA viruses encode one or two papain-like leader proteinases, belonging to Merops peptidase family C42.	25.00	25.00	27.40	37.70	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.20	0.72	-4.16	8	200	2012-10-10 12:56:15	2003-04-07 12:59:11	7	8	8	0	0	172	0	73.20	66	10.95	CHANGED	tchtDGhCYlAHhthlCAahsRsFccpDa....sLGsaPTVucL+sRlh+paGccALplslRGtYoSRslFHCDYsuuaspsh+slsua..lGG	.A.KlRDGQCYlRHVYDVALYFGRRV..DLSV+...RTLGhFPTVGALKAYLVREYGR-SLKVPMRGTYT................................................	0	0	0	0
+5362	PF05534	HicB		HicB family	Moxon SJ	anon	Pfam-B_6090 (release 8.0)	Family	This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches [1]. 	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.41	0.72	-4.39	24	1200	2012-10-02 18:44:02	2003-04-07 12:59:11	7	4	929	0	259	814	64	48.00	32	43.10	CHANGED	YlpsCpp.GhpPc+taS..GpFslRlsP-LHccluhtAtppslSLNpalppsL	.......................t.p....t.....s..t.t.hp....t....p...FsLR.lsppLHccLshtAtppslSlNpalhphL...........	1	79	171	225
+5363	PF05535	Chromadorea_ALT		Chromadorea ALT protein	Moxon SJ	anon	Pfam-B_7314 (release 8.0)	Family	This family consists of several ALT protein homologues found in nematodes. Lymphatic filariasis is a major tropical disease caused by the mosquito borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangitis and elephantiasis. Expression of alt-1 and alt-2 is initiated midway through development in the mosquito, peaking in the infective larva and declining sharply following entry into the host. ALT-1 and the closely related ALT-2 have been found to be strong candidates for a future vaccine against human filariasis [1].	25.00	25.00	34.70	33.80	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.10	0.72	-3.89	6	43	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	13	0	24	44	0	75.70	56	34.20	CHANGED	EalsKGcFVETDGKKKpCcoHpACYDQREPQuWChLKps.QuWTs+GCFC-pKh+uCVIER..psssKLEYoYCuPccsWpCu	..............ss+GcFVcTDG+cKpCpSHpsCYDQREPpuWChLpcN.QuWTs+GCFCDsKL+SCVIER..pN....s....G+L....EYuYCsPcpsWpCp.......	0	16	16	24
+5364	PF05536	Neurochondrin		Neurochondrin	Moxon SJ	anon	Pfam-B_7411 (release 8.0)	Family	This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain [1].	19.10	19.10	19.10	19.10	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	543	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.72	0.70	-6.20	8	217	2012-10-11 20:01:00	2003-04-07 12:59:11	6	15	138	0	160	237	0	430.60	20	74.69	CHANGED	psssssL-cCLpLL+up+.Dop+FAuLLLVTKhl+usDhsuts+chlF...-AVGhpFLcRLLpotp...ussss....sccsahsLulolLusFCs..-PElAscppVls+IPhls-slppsss......hshl--sYpsLsulu.uoPpGs+sLlstGslshLsptYss...puashEpAlplLhsLlsshcspshp.-c..thpsllsplucpFssh-sspKFEL...hclLsslLspp....l...lpS..upphhcpLptGlssILps+losupRssALpLAAsLhps...hGspWlhsssp..............ss+FlhLllsluslEVRhsLsE.............pspshtp+pcslosCauLlEhhIphhsc..pt-psll-.....csphhpLhssLpEshusVlcaLpcst-................................-p.+-s.......hllAuVRlLGuWLAE-ssu.h+pclppLLsFhlclt+csapp...hpt...................shDulRalLPuLCplosEccsp+lLhspGusplLsD......sl.............lphhcc.ps..s...suEh.....ul.hhCshhhNlllstssh.hpctusFsuLh+sLlp...........................................................sssusctsslhhSsuhpuhWtDl...sphW	...........................................................................t......htph.thLpttp.DppphsuLhhlpphhp..s.tp..t.st.........lh.................culu...pF.p+LL.ot...............tt..............................t.hhtlulslLtsast.........phttp..ph.hstlPhl.phltttss..........................thhp-shphLhsls.up.tG.pthht...ssls.hlsphh.t............................psh....h-..shtlhhhl.ht..t..ht.......h....pt...h..tl.h.tt....lu..ht.t.psttthph.....................hphLs.hl......................................h..pl..hl.tll.ts.+.s...t................+..h.h.lhtthhph....hu.phh..t...................................t.ahhlllp.hhl-lph.h.p............................h.....tp.ls.sa.lhp.hlt...h.p........tt.....t..............................................h.phhp.hptshshhhthL.t..ph.........................................................p..t...pc..................lhu...lRhls.altpps.t.hp.th....tlhshhhph.tt....t........................................................................hphhLshhpthsh.......p.tstphhht...tt.thlhp..........h.....................................................t.........................................................................................................................................................................................................................................................................	1	53	94	131
+5365	PF05537	DUF759		Borrelia burgdorferi protein of unknown function (DUF759)	Moxon SJ	anon	Pfam-B_7415 (release 8.0)	Family	This family consists of several uncharacterised proteins from the Lyme disease spirochete Borrelia burgdorferi.	19.90	19.90	21.30	20.10	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.61	0.70	-5.71	2	148	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	27	0	12	135	0	319.00	50	87.42	CHANGED	MSDKFTIKFKGILDHAATKKAIEQDISKMEKYLKPKKSSLGSTKDIVKNNLSDKKKELS+QSKFESLRERVEKYRLTQTKKLhKQGMGFEKARKEAF+RSLMSDRDKRRLEYKELAKESKAKSKMLAASQGKGLVAKIAIGSALGNlIuNAMSKVGGGLlGF....hKKuVE-soKpc+hQ.LNpshYGs.KE+-slLK.IGtMKGFcRsLEKE-FLppA.VhKGslR-Lc.LN-...pNlhNAschAAMh+SoGhhS.sEsuVpAVsplLtG-hoEhashLK..sthG-KYlEshK.th....QpGuplcLcscI..hh-hhKDhpShtlhthssshEphpssLAshEQTLpsLTssVLcPllslIs.hhsK....ItNFs.hpslINsIhNuIpShhsh...FsKl+uhLPphhGGsGs-s....p..scspsssNs	.......................MSDKFTIKFKGlLDHAATKKAIEQDIoKMEKYLKPKKSSLG.STKDIVKNNLSDKKKELu+QSKFESLRERVEKYRLTQTKKLhKQGMGFEKARKEAF+RSLMSD+DKRRL.EYKELAKESKAKsKMlAASQGKGL..VAKIAIGSALGNlIuNAhSKVGGGhlGF....hKKuVEppoKpc+hp....LNpsha.........sc.c.........E+........ptlh......t.......hltt......hKGFERcLEKE-FLppuolhKG.slp...-Lp..LNp...pNlhpAschAAhh+SoGhhu.sEpAlpsVsphLpG-hsphaphhp....sthG..pKYhEshK.th....Qpuu.ph.chc.cl..hhchh.pDhpShtlhthusphpphpssLsphEQoLtslTssllpPllthlp.hhth.....h.tap....ptllt.hh....pu....l....pshhs....................................................................................................................................	2	7	8	8
+5366	PF05538	Campylo_MOMP		Campylobacter major outer membrane protein	Moxon SJ	anon	Pfam-B_7418 (release 8.0)	Family	This family consists of Campylobacter major outer membrane proteins. The major outer membrane protein (MOMP), a putative porin and a multifunction surface protein of Campylobacter jejuni, may play an important role in the adaptation of the organism to various host environments [1]. 	19.90	19.90	21.00	20.90	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.48	0.70	-6.10	2	514	2012-10-03 17:14:37	2003-04-07 12:59:11	6	2	136	0	23	333	1	274.10	49	99.06	CHANGED	MKLVKlSLVAALAAGAFSAANATPLEEAIKDlDVSGVLRYRY-ouN..pNhs.sSslss.KQDHKYRAQVNFSuAIuDNFKAFlQFDYNu.DGGhGsDsloNspcsLhVRQLYLTYTNEDVATSVIAGKQQLNhIWTDNuIDGLVGTGlKVVNNSIDGLTLAAFAhDSF.ttppssshlsQss.pphp............pssshtlD.stNlYGAAAlGSYDlAGGQFNPQLWLAYhspsAFhYAlDAAYSTTIFDGINWTlEGAYLGNSlDscLcD+hc.ANGNhFAL+GolEVNGWDASLGGLYYGcK-KsohssIEDQGNLGSLLAGEEIFYTsGSpLNGDhGRNIFGYVTuGYTFNETVRVGADFVYGGTKTp.hup..GGKKLEAVARVDYKYSPKLNFSAFYSYVNlD...sssESscHssVRLQALYKF	...............................F.S....s.AsPLEEAIKDlDVSGVlRYR.Y-os.........p.p........p..s....h.......s...........p.s....s.s.......ls.......s.KtpHpa+uphsFpu....AlsDN....Ftuhl...........ph...pY.s..s........-.......s......G..........h....G.........h.............s...t...........h...........p.......s...s...........p........p.t...h....VpphYLsYTspsh.s.TolhhGKQtlshhaT...Ds.s....sGTGl+VlNssIsGLTLA.uhAhDuh.tt...t.............................................................tslYususlGsa-.....hs.QL..WhAhhsp.s..u..h...a.......A...h.Dhshph.hhsshshtlputYhtsshD.sp.......htt.............................................s....suN......hauhphshph.shDhthGh.l..ha..t..pc.p....c....h..o.hsslEDpGph........hh.......sGt..plh....s..ptpt.h..s....ucN....ah..ahthGYoF.sc..hplGh-al.Gt.ps...............t..cc.......E...hssplsYtYS.KLsh.saYuh.hp.....................................................................................................................................................................................................................................................................................................	0	6	14	23
+5367	PF05539	Pneumo_att_G		Pneumovirinae attachment membrane glycoprotein G	Moxon SJ	anon	Pfam-B_7428 (release 8.0)	Family	\N	25.00	25.00	83.60	83.60	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.71	0.70	-5.09	3	103	2009-09-11 11:15:31	2003-04-07 12:59:11	6	1	3	0	0	83	0	160.30	60	99.79	CHANGED	MGSKLYhIpGsSuuQlslKpsL+lucKllLuIVLSALGLTsToTIALSISISVEQuVLc-C.cTYhusssohaSsosspsTTTsoATTT+DhRGLQTTRTRKhESCuaVQIuYGDMHDRSssVLGGlDCLGLLALCESGPICQRDsps-DsshCRCTlcu+uVSCCKcPKousTTSpTTScPscs.osPsaPSQcsocScPsoQGcQT....oTAspploSTsshhTpcTuTsosucPQspPsPSppG.osos+csuSTsSpcooT.sGsupcHTQRh+TPPos-NsRoshppsTP..TT.hacTt+PTP+PTs-hpsssp.spoSPsulQuNPTTQ.N.lsCcchDPscPp+ICYpVGoYNsulo+sCcI-VPLCSTYspsCMcTYYocPFNCWRRspRClCD-GsGLIEWCCTS	...............................ch.p+hlLulVLSAhGLThTsTIslolsl.VEQshLcpC.csY.utstshassppppsTos.stTssts.ttLQsststK.ESChaVQls.GDMasRS.sVL..........................................................................................................................................................................................................................................................................................................	0	0	0	0
+5368	PF05540	Serpulina_VSP		Serpulina hyodysenteriae variable surface protein	Moxon SJ	anon	Pfam-B_7432 (release 8.0)	Family	This family consists of several variable surface proteins from Serpulina hyodysenteriae.	22.90	22.90	23.10	44.80	17.40	22.80	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.34	0.70	-5.69	4	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	5	0	26	43	0	353.80	47	99.32	CHANGED	MKKhLLsslAlLTIuSuSsFGMYGDpDsWIDFLTcGNQFRARMDQLGFVLGNsTIKGTFGFRoQslsTtLGsIl.oGNstNhs.LpsTISsGIGYTS-sFGIGlGYNYTY.........hssslGsHTPVLMlNALNNNLRIAIPVQIAVp+DshsKhs.....pspKDYLGISTDhQIRYYTGIDAFNtIRLYhKYGQsGYKss.....NsspEhFAQShGFEsRhYFLNTslG.NVTINPFIKVsYNTAL..+GsushVRAu-ohhss.....stsh.s.cP............th-.KaD+NPYDVpstAVLGlTANSDhVSLYVEPSLGYpApYhGKhto-p..h....KVpHsLhWGAYAELYIpPVQDLEWYFEMDlNNusS+.......p.sulPVsFuooTGITWYLPtL	............................................................MKKhhLhhhslLohu.sSlFGMYGsp.-sWIDFLscGNQhRARMDQLGFlLGNsTIKGTFGF+.upo....h..s.lGpIL..s.....s.spssht.LtsTISuGIGYTS-sFGIGlGYNYTa..........hu.sshssHTPVLhlNALNsNLRIslPVQIuVpssshsphs.........ppsYhGlS.T.D.sQIRYY..T..GIDAFNtIRlalKYGp.saKss.............................shs....p-hhApShGF-hRhYFLNTslG.NVTlNPFl+VsYsTAL...pGh...uphlts..h-..shhps...............h.th.sstssst................................ssh.sthaD+sPYclsltssLGlTANS..DlVSLYlEPuLGYpsph.h......G+h.ss.tst.........Klp..HtLuWuAYuELYIpPVpDLEWYFEMD...VNNussp.......p.sul......PVsFsuoTGITWYLPth............................................................	0	7	7	7
+5369	PF05541	Spheroidin		Entomopoxvirus spheroidin protein	Moxon SJ	anon	Pfam-B_7488 (release 8.0)	Family	Entomopoxviruses (EPVs) are large (300-400 nm) oval-shaped viruses replicating in the cytoplasm of their insect host cells. At the end of their replicative cycle EPVs virions are occluded in a highly expressed protein called spheroidin. This protein forms large (5-20 mm long) oval-shaped occlusion bodies (OBs) called spherules. The infectious cycle of EPVs begins with the ingestion by the insect host of the spherules, their dissolution by the alkaline reducing conditions of the midgut fluid and the release of virions in the midgut lumen. The infective particles first replicate in midgut epithelial cells, then pass the gut barrier to colonise the internal tissues, mainly the fat body cells. Whilst spheroidin has been demonstrated to be non-essential for viral replication, it plays an essential role in the natural biological cycle of the virus in protecting virions from adverse environmental conditions (e.g. UV degradation) and thus improving transmission efficacy. In this respect, spheroidins are functionally similar to polyhedrins of baculoviruses or cypoviruses [1].	25.00	25.00	61.80	61.20	21.70	21.30	hmmbuild  -o /dev/null HMM SEED	944	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.53	0.70	-6.94	4	11	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	11	0	1	11	0	866.40	39	92.91	CHANGED	sNlPlsscpIpKlsspKYEl+hhLKD-sppF-+h.l-hVVPLYDsss.houVTlESsssslEllELDpTHhRlhl+ssshcEhsa.hsFsssVsp-pVWKYlocLLLsNluhsssKhKLsNaplsLNsKHlphpclcpsLFIhFhDD.GhYGLIT+cNI.NssL.VsKDAoaIplFPQahYhphGRclYlNEKsThDVss-ssNlsLDhpKSVNIuVS...FlsI.YElssstQKcLLKsLlp+YGcFDVYNADTGLlYAKNLsIKs.sT.VIQV-+lPVpLKVKAYhKs.sG+sLChh+ITSST.sDPEYVsSpsAhLGsL.pVYKKFc...+ShLKlhhHscsosNVhPstsLhLELsDspsYshKsSssSRLsVGlYKlsKIYlcNscspIhLcpIcscacCs+pla+EhspL.+................cps+YTscs.FpIlsNsPchslalaG.IpNlsh+sKsshNL+LWGWIlcsDsSRal+hhsDGSlDLDLshKhspsDlsLhpAl+p+YhNslILEhANsY.ssslSLGNp+FpNIFDMc.cscoIspYTNFTKsRQDLNNhuClLGINIGspVNIpsLP..GWlss+EhcILp.Susscl+pFscuFCclsN+RFasMA+DllSLLFMCNYlNIEIsEulC-YPGYllLFARAlKVINDlLLlNGlspLAGYSISlPlcaGss-KTLPpp+pGGV-K+FKchFLKspL+-LM+Dp-FVQsPLYISTYF+ol.-sP.o-NYEKYLl-SusQSQ-lLQGLLNTpNo.DTNARVsSSVhG.asY......-.ssTuEacIu.............................sEALsKhsK.ho+.GNhGLlN+lsE....pC...s.cGh.-Nppl+sph.pp.FsCpPNNNsELIs+YGY+lhDLc+ItplhsshDs...sspcpshh.E-pt.h..s..h.h.a.....spssp....phs.ClppN.pp+ha.pcCscssoCs+......Rps........h...sGYc+sH	..........NIslplh-lpplNDupapV+Fs...-shpFstK.hshVVP.YssD....hVslEouDsNl.l.-hspT+Y..lhapsptsEhshhFoFsssVDp-plhpYlopLlhsNLu.hssK.hlhNhslhlNGhh.shhthspshaIhhaspssshhLloppsIhNpoLlVsKDsoalpl.sQ+lhsactphlYlsEpsT.DVs.sVsNlVLDL+puVsluVS...FlShshEls-ssQKcll.SLlp+hGcFDlhNADTGhVYt+NLslKpssThsh.V-p.sV+lpsKshhh.hcs+slp.hplhSs...Ds-YVsscouohthL.olYhKhhptIKSLLKIhhpDccssshh.GhshslEhpDhNshshphossoRLslGlYplchlYLsspcDpIp.phIc.........aK-YVs.sca-..............p-G+YpshssFhIhuNpPhIslalhGcIhsss.cscsshpLpLhG..lDhcsShY...as-suLsL...a+pcsssloLhcAlKh+alNsIlhcsANhh.sGsIolGN+Ka.NIhDh+tDscTlNpYsNhhhu+pshNs.uslLulslss.VNIQ-LP..sWLss+....LusSusD.l+shlpuFss.ss+caashs+sIlSLLhhsNaINhpIc-oLCcYPGhIhLFARhhKhIN-hLhl.G..phAhYSloh.scauss-phLPas+ptGl.KcFh+pahKsshpsLM+Dcsa.QsPLhI.s.hpslpps.....ssNhtp.lss.......SAsps.sLlptLLsopNspDsss+.Vl.SshGuF..........sNhu-pcIs.............................ppslSpllchhp+sGshGLl.+.s................-NpsI+ph+spspF.sp.Ns.scLIphhuap..DhpthhchhsssD-lP.ssscpshh-EDpt.hh.s..hsh.as....spssp.......s.Chpspspp+hh.spCspsssCs+.......+ps........a...sGh.hsH..............................	0	0	1	1
+5370	PF05542	DUF760		Protein of unknown function (DUF760)	Moxon SJ	anon	Pfam-B_7508 (release 8.0)	Family	This family contains several uncharacterised plant proteins.	20.20	20.20	20.60	23.20	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.61	0.72	-3.80	54	380	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	117	0	216	365	110	97.80	30	44.47	CHANGED	ssLhpYlpphpP.-tlsplsc.............................................ssSs-lhpshcps....lpullGsL..P...................................sttFpsplpss+-pLupLlhushMoGYaLRphEpRhpL-psLp	...............LhchlpplpP..-plpplsc.............................................ssSs-lh-hhcps....lpslLGhl...P......................................spphsshlpss+ppLup....Lhsu.uhMsGYaLRphE.RhpLEcsL...................	2	48	141	188
+5371	PF05543	Peptidase_C47		Staphopain peptidase C47	Studholme DJ	anon	Merops	Family	Staphopains are one of four major families of  proteinases secreted by  the Gram-positive Staphylococcus aureus. These staphylococcal cysteine proteases are secreted as preproenzymes that are proteolytically cleaved to generate the mature enzyme.	21.60	21.60	21.80	24.20	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.85	4	395	2012-10-10 12:56:15	2003-04-07 12:59:11	8	3	221	9	4	118	0	172.80	60	44.73	CHANGED	shpsQYVNpLKNFKIRETQGsNuWCAGYTMSALLNATYNTs+YNAEuVMRaLHPNLpGc-FQFTGLTPpEMl+aGpSQGRssQaLNRMsSYNEVDpLTpNNKGIAILGpRVESs.sGhHAGHAMAVVGNAKlNNGQ-VIlIWNPWDsGhMTQDAcSNlIPVSNGDHYpW.uSIYGY	.........p..p.QY.NpLcNFKIREpQhsNuWCAGaoMuALLNAThNTspYpAcslMRhLaPplptQch.....s.u....hhP..p....pMIpa.GpoQ.GRs..ph.pths....o...YNpVDpLTKsNhGIhlLup.pVppp....Ns.HhGHAhAVVGN..AKlNs........QEh.....lIhWNPWDsth.hQDAcss..ll.lS..sccYpWYuShhGY...............................	0	2	2	4
+5372	PF05544	Pro_racemase		Proline racemase	Moxon SJ	anon	Pfam-B_7562 (release 8.0)	Family	This family consists of proline racemase (EC 5.1.1.4) proteins which catalyse the interconversion of L- and D-proline in bacteria [1]. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterised as a co-factor-independent proline racemase [2].	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.77	0.70	-5.60	14	1248	2012-10-03 03:02:41	2003-04-07 12:59:11	6	8	740	7	380	1522	561	313.20	35	95.24	CHANGED	llDsHspGEssRllsGGssslsGsThhE+ppahtp-h..DtlRphlhhEPRGpshhpuslLhPPpcP-AshGhlhhEsssh.sMsGpsoIslsTsLlEsGllshp...pPtscl...L-sPuGlVcspscscsG...psppVplpNVPSFhathDstl-VsGl.GclpVDlAYGGsaaAlV-spphGhslssspAp-Lsshu.tlppAlscphth.HPcts-hstlsas.hsussspsps..suRNsVhhsstthDRSPCGTGoSARhAsLtA+GpLcsG-palpc.SlIGStFcG+l.thscluG+s............AIlPpIuG+AalTGhsphhlDPsDPaspGap	...............................lDsHssGEPsRll....h...u..G.hP..pl....G..tT.hhE+p..p.a.........h......tp.ch...........DtlRphLhhEP.RGassM.GulLs.P..Ps.......c....s....c.ADhGV.lFhcs......s......G.h.h.s.M..CGHuoIulsT.s.hl.E...p.........G..hls.s.p...........ps..t.....p.....hh..l.-.o..P.uG.l..V.ps.ph...p.h....c.su........cst...pVohp.N.V......Pu......Fh....h...p...p...sl.p....l.........-l...........s......s.........h.G......p.....lp.sD........lAaG..Gs.aY....ulV-....spp.h....G..h....c...l..ssp.s.....sppLhphuht....l+p..sl....pp....p....h..t....h.....H.Pp.t..slptlst..l.hh...ss.....s.....pptts...............ss+NsVhh............s.....s............s...t............l............DRSPCGTGT.SA+hAtLhA+GcLphG-.p.ah.pc.SI....l....G...S.h......F.....pGc......l....p..t.....s..p..l.u...s.h..............AllPplsGp.AaloGhsphhlD.s.p.DPhstGF......................................................................................................................................	0	106	211	297
+5373	PF05545	FixQ		Cbb3-type cytochrome oxidase component FixQ	Moxon SJ	anon	Pfam-B_7570 (release 8.0)	Family	This family consists of several Cbb3-type cytochrome oxidase components (FixQ/CcoQ). FixQ is found in nitrogen fixing bacteria. Since nitrogen fixation is an energy-consuming process, effective symbioses depend on operation of a respiratory chain with a high affinity for O2, closely coupled to ATP production. This requirement is fulfilled by a special three-subunit terminal oxidase (cytochrome terminal oxidase cbb3), which was first identified in Bradyrhizobium japonicum as the product of the fixNOQP operon [1].	22.80	22.80	22.90	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.19	0.72	-4.32	127	974	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	905	0	280	665	58	46.80	27	73.61	CHANGED	h..............shhpuhhslhhhlhFlGllhWAa.pspp..+ppa--AAplPFc..--	........................shhpuhhslhhhlhFlullhasa..pscp...+ppa--uAplshp.D-...........	0	64	169	223
+5374	PF05546	She9_MDM33		She9 / Mdm33 family	Wood V	anon	Pfam-B_35269 (Release 8.0)	Family	Members of this family are mitochondrial inner membrane proteins with a role in inner mitochondrial membrane organisation and biogenesis [1].	20.50	20.50	21.00	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.31	0.70	-4.78	17	144	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	138	0	112	152	5	193.70	44	44.52	CHANGED	pphu..++hphhhDslQpslhsAopsLNDlTGYSuIEcLKpsIpphEpcLcps+ppl+psKttYspAIpcRSpSQREVNELLpRKcsWSPsDLERFTpLYRsDHsNpppEp-uppcLp-uEpcs-plpspLhpuILoRYHEEQIWSDKIRRsSTWGTahLMGlNllLFllhQLllEPWKR+RLVtuFE-KV+pAlct.tpppphthpphl	..............................s..hscphsphhDslQsslhsAsppLNDlTG..YSuIEpLKpplpt.Epclcps+ppl+pAKpsYpsAlspRusSQREVN-LLpRKcsWossDLER.FTpLYRsDHtNEptEtcupptLspAEpct-chtspLtpuILsRYHEEQlWSDKIRRhSTWGTauLMGlNllLFllhQlhlEPW+R+RLVpuFE-+Vppslcc.pt.........th.......................	0	32	65	98
+5375	PF05547	Peptidase_M6		Immune inhibitor A peptidase M6	Studholme DJ	anon	Merops	Domain	The insect pathogenic  Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homologue of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae [4].	23.70	23.70	23.70	23.70	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	646	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.02	0.70	-6.49	5	820	2012-10-03 04:41:15	2003-04-07 12:59:11	6	51	467	0	195	739	218	459.10	29	56.97	CHANGED	susQssasGsVRoDKVLVLLVEFuDhs...........HNsIsKpss.....pMYp-DYspEHYQDMLFGccsYoh.cGcslpShKQYYEcQSGGSYoVDGpVocWl+VPtsAAcYGuN.usGsDNpuP+uARDLVKEALc.......sAs-pslDLoQFDQaDRYDhNGDGNhNEPDGlIDHLMIIHAGVGEEAGGGsLG-DAIWSHRapluscshulEGTpusVs....haGGchAAaDYTIpPEDGAlGVaAHEYGHDLGLPDEYDTpYTGsGEPVuaWSlMSSGSWuGKIuGTEPTuFSupsK-FhQKslGGNWhNh.plDhsKLssspG+sssLDQosTKSsRPshV+VsLPpKoVEsIKPApGcatYYSs+GDDL+NTLST.slDLTsuTsAcFcFKuWY-IEADYDFlcVch..VopDGspThh-csGcpssssstcsss.....sGK...WIDtsYDLSsatGKKVcLpF-YlTDGGLAMcGFhlD-luLTVDGcssFSDDAEG.TSpasLsGFT+suG..T+cpsHYYllEWRNHsGoDsGLtp.........h.+aucthuYssGLVVWYsDsSYADNWVGlHPG+GFLGVVDSHPcALVhspsGclAcs...RaQltDAAFShcKTsuhplso...uTsuTasssuLuussoFDDc+sYhspQlPDuGRKlPchGLKhcVluQAcDsSsGsV	....................................................................................................t.............phhslLh-asD.......................................sth....t.............h......p...a..taapphh...as.p.................................u...p...p...h..........oh+pYapppSsspass........s....G...t.l..t......t.Whps.s.tptu...YGss.......s.s....p.........s................s....................s.......t...sp-h.lp-Alt.....................hsh..t...sh.slupaD....ctYD.susGs.pp.sDG.hlDplhllH.AGhGp...ps.G..G....G.h......t....s......s..AIWuH+......t...h....s............t................h......s..h....p..G.....sp.......th.................hhs.s.th...t.s...h..-...Y.....s......h..p.............P...........s.......u........u......hGVhsHEaGH.s.L.G.LPD.Y..D.T.............s...G...t.s..........p...s............l.....t.WolMuuGS..W.....s..G.......ph....s......s.s.t..ssshss....pt.a.p.th.....s....W..hp................h......t..t........................................................................ts.....Gp........aaSs...pu.ss.h...p.s....p...hpp......h....slst...s.s...p..A...p...h...phc...shaplE.........t.....p.......aDah.V....hs.sGt.......shhp................h....p...s......s....t..sts.........................................st........WhchphD.L..ota..tG.p.p.l.pltFpYhTD........uh......s.......h......p......GhhhDshtl...p......s...st..hh.sshc.....s......th...........h.........................G..a.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	83	136	171
+5376	PF05548	Peptidase_M11		Gametolysin peptidase M11	Studholme DJ	anon	Merops	Family	In the unicellular biflagellated alga, Chlamydomonas reinhardtii, gametolysin, a zinc-containing metallo-protease, is responsible for the degradation of the cell wall. Homologues of gametolysin have also been reported in the simple multicellular organism, Volvox.	20.60	20.60	21.40	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.17	0.70	-5.50	6	219	2012-10-03 04:41:15	2003-04-07 12:59:11	6	11	37	0	180	218	11	252.00	23	45.09	CHANGED	RLLVhILDYSoC...Ga..usolTE-plRslFLGPNpDGsGGlApKYspCSYsKFuLN.sTAFhsVt.VslsCoosVT................uoCS...........WWslSp............tADsAA+All.............GlsAF..uoFoHasYVLPPGlp..CuWAGLAll.P.G+psaLpoSuYGlpRWu......TlMQEAlHNYGLWHSWRNshEYEDaSTAM......G....RGsACPNAuEhSRlGWATP...........AsGG.Gslsuushsss....GostsasLPAThlTGDsNaLRV...lPsWLsshhNuTsAKNLYluhRVsKsG....DuALsupausKVpVHEVNATMDN.uhsspahpSDR+IpFluusssho+usLsA	....................................................................................................................h...h...................................s..htthh.t.CShsph.h....t.s.......hhh....l....s.Cts.............................................ps.s........................h...h.shtt.........................h.u.c...th.s...ps................G....sh.......ss.ap...+.hhalhP...s..t...........C..s....a..s..G.....hu.l....s....G..p............s.h...h.t.h.s..s....h......p..h.s............................slhpEhhHNh.G..LhHu...........h............p............s........s................h.............EY....s...D.os...sM..........G...........pu....t.......C......N.As.ph...........phGW..hss...............h.........tls..ssth..............u.hh.thtl.sst.....s....ts.hlhl............sh............................................................................hahthR.tt.s.........................D....h............................................................................s............................................................................................	0	70	174	179
+5377	PF05549	Allexi_40kDa		Allexivirus 40kDa protein	Moxon SJ	anon	Pfam-B_7591 (release 8.0)	Family	\N	21.20	21.20	21.20	22.10	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.85	0.70	-5.10	7	19	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	0	0	20	0	234.20	36	68.90	CHANGED	pRTFFSNhshAL-ATpsLLsaVPPsRYslPssoLPLDELYGQLHALHpNSLEWLTHIsHssDpllshLNshs..u......psssLuclRsslppLsphlppltss.pphphphppsssoc.hpphpsl-TpLptLHt+lc.hsps.spssss.Pssossssss.sstsscs.LPhYQAtHPTt.CRoYGollasGss.+IPMDIhGRPASTAL+LplplsssspsTpVsYclhDDGhLLLS--lcTtHKLpH..SDsLALLHp+CPNFIYKI+scsLC	........pRsFFoNhshALsuTpsLlsaVPPsRYslPssoLPLDELaG.LHALHpNoLEWLTHIspss-plls.hssh...s......pss.Lscl+stlpsLsphlpplpps.pp...phpspp.tspp.hcplpulcspLttlp..h+lp.hspp.sps.st.Psso.spssso.sststps.LPsapApHPothCRoYGollasGhsh+IPMDlhGR.sSTAL+Lplphp.sspsTpVpaclhDsGhLLhS-plpT.H+Lp+..uDsLuLLHp+CPNFlY+h+spsLC......	0	0	0	0
+5378	PF05550	Peptidase_C53		Pestivirus Npro endopeptidase C53	Studholme DJ, Finn RD	anon	Merops	Domain	Unique to pestiviruses, the N-terminal protein encoded by the bovine viral diarrhoea virus genome is a cysteine protease (Npro) responsible for  a self-cleavage that releases the N terminus of the core protein.  This unique protease is dispensable for viral replication, and its  coding region can be replaced by a ubiquitin gene directly fused in frame to the core. 	20.70	20.70	21.10	23.00	20.60	19.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.16	0.71	-4.79	11	688	2009-09-11 10:39:17	2003-04-07 12:59:11	6	19	89	0	1	634	0	153.70	75	17.82	CHANGED	MELlcFELLYKTuKQ+PlGVhEPVYDpsGcPLFGEhScIHPQSTLKLPHcRGcA-l.TsLKsLP+KGDCRSGNppGPVSGIYIKPGPVaYQDYpGPVYHRAPLELFsEoQhCEVTKRIGRVTGSDGKLYHlYVClDGCILLKpAoRspscVLKWl+NhLDCPLWVTSC	...........................................................MELhsNELLYKTYKQKPsGVEEPVYDpsGsPLFGE+.u.sIHPQSTLKLPHcRGct-VsTNLtSLP++GDCRSGNs+GPVSGIYlKPGPlFYQDYpGPVYHRAPLEhFcEus.MCEsTKRIGRVTGSDGKLYH..IYVClDGCIl.lK.As+s.p.clL+WlhNhLsCPLWVoSC....................	0	0	1	1
+5379	PF05551	zf-His_Me_endon	Naegl_SSU_RRNA; DUF1519;	Zinc-binding loop region of homing endonuclease	Moxon SJ, Coggill P	anon	Pfam-B_7681 (release 8.0)	Domain	This domain [1] is the short zinc-binding loops region of a number of much longer chain homing endonucleases. Such loops are probably stabilised by the zinc and may be viewed as small but separate domains. The common structural feature of these domains is that at least three zinc ligands lie very close to each other in the sequence and are not incorporated into regular secondary structural elements. The biological roles played by these small zinc-binding domains are presently unknown [2].	27.00	27.00	27.20	27.20	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.21	0.71	-4.17	11	70	2012-10-05 18:28:12	2003-04-07 12:59:11	6	2	41	18	21	82	4	122.00	30	40.93	CHANGED	sCah.psspsst.psGY.plsh+ss..................tGpphYsH+l.shhAsscs.......t.h..h.tt.....uhplSHLCtNutChsPsHLllEspslNppRpsCp...tpsp.h.tst.hhpsC.H.....pPpC..lhshtthscshp	..........................................................................Ch..tsth....psGa.+hphhsp......................ttsp.YhHpl.shhAssptt...........phh.hl.psch.........uhplSHLC.........pNu.....tChpPsHLhlEs+s.NccRppCp............t+...h..ps...th.hhtsC.....H........pspC..hlshhhhsp...........................................	0	12	17	20
+5380	PF05552	TM_helix	tm_helix; 	Conserved TM helix	Yeats C	anon	Yeats C	Family	This alignment represents a conserved transmembrane helix as well as some flanking sequence. It is often found in association with Pfam:PF00924.	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.33	0.72	-4.30	143	2106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	1303	14	507	1422	120	52.30	28	24.15	CHANGED	tpslsshhspll....salP........plluAlllLllGhllucllpphl.......splLpphsh.Dptls	....................p.hss..sh.ll......sahs........NlluAllIlllGhllA+hlsshV.......s+lhtpt.pl.Dttl.......................................	0	135	297	397
+5381	PF05553	DUF761		Cotton fibre expressed protein	Moxon SJ	anon	Pfam-B_7657 (release 8.0)	Family	This family consists of several plant proteins of unknown function. Three of the sequences (from Gossypium hirsutum) in this family are described as cotton fibre expressed proteins [1]. The remaining sequences, found in Arabidopsis thaliana, are uncharacterised.	19.00	19.00	19.00	19.00	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.82	0.72	-4.59	85	622	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	28	0	391	568	2	34.10	34	13.27	CHANGED	sps-.lsp+AEcFIp+F+cph+.LQ+...........pShp........p..hpphls.+u	......pp-.lDp+A....-cFIp+Fpcp....h+.lQ+............Sh........t..............................	1	33	211	313
+5382	PF05554	Novirhabdo_Nv		Viral hemorrhagic septicemia virus non-virion protein	Moxon SJ	anon	Pfam-B_7684 (release 8.0)	Family	This family consists of several viral hemorrhagic septicemia virus non-virion (Nv) proteins. The NV protein is a nonstructural protein absent from mature virions although it is present in infected cells. The function of this protein is unknown [1].	25.00	25.00	228.90	228.80	20.30	17.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.54	0.71	-4.58	3	37	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	3	0	0	29	0	122.00	86	99.65	CHANGED	MTTQSAHSTTSFSPLVLREMITHRLTFDPSNYLNCDLDRSDISsTDFFETTLPRILcDLRASTRLPYLHVLDMRISLLERTHYMFRNVPSSPATTGRhSDPELlIISHAEMtlLTsGSESTS	MATQPALSTTSFSPLVLREMITHRLKFDPSNYLNCDLDRSDISThDFFETTLPRIL-DLRASTRLPYLHVLDMRISLLERTHYMFRNVPSSPATTGRLTDPGLlIISHAEVGlLTsGSGLTS.	0	0	0	0
+5383	PF05555	DUF762		Coxiella burnetii protein of unknown function (DUF762)	Moxon SJ	anon	Pfam-B_7710 (release 8.0)	Family	This family consists several of several uncharacterised proteins from the bacterium Coxiella burnetii. Coxiella burnetii is the causative agent of the Q fever disease.	25.00	25.00	202.60	202.40	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.65	0.70	-5.14	3	27	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	7	0	3	18	0	237.60	53	99.52	CHANGED	M..saFhh.PKIDaQ-+......oNSQss.EcTLQEWLRGA..NssEcAslFIuSspppphPIhu-pp.sSuusLPKLcIc-IcsSIKhVcNpFKKaGLKDEsIlNYIL+aGGINGYsSLGpssLcclsplpGsspcsEN+.........+pTYhV+uKscVpYIEpFcllpls.hDRNsIGcF..luEVK.sollSKsG-IIHsCKKVplts.sApLchFKs+FGsQLphVETI+++LhElLsSLYpRlsplFN........EspNccsRssKpRhPGhu	.........l.cIDhpph......psSpss.EcsLpEWLRGA..ss.EcAplFIsss.....PIhupp..sSuusL.KlcI.-hhssIh...s.FKh.GLKsE.IlNYILpaGGIsGYhoLGpsshcclshspGpspcsEN+.........+hoYhV+sKscVpYIEpFchhphs.hDRNpIGcF..lupVK.sollSKsG-I.HsCKKVplts.stpLp.F+p+FGsQLphVpph+h+LhElhsSLhpR....Fp........tthNctsRssppphPhhp.	0	3	3	3
+5384	PF05556	Calsarcin		Calcineurin-binding protein (Calsarcin)	Moxon SJ	anon	Pfam-B_7783 (release 8.0)	Family	This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation [1]. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin [2].	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.97	0.70	-5.17	14	220	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	47	0	93	173	0	230.20	35	93.44	CHANGED	Ms.tst..spp++ppustIhp-lst.stp-.t.......pLDLGKKlSlP+DlMLEELSLhsNRGS+hFKhRQ+RVEKFhaEs.......hsspspsphpphsss.ssp...............tph....ust...s.s...sst.ht.....sPpsluPG..usPhKtlP...............................................scKhppsslsKoYhSPW-cAhss-.-hltshtsphPtP.ttp.p.scYKSFNRsAhPFGGac+As+hhshphPc.hp.s...s..hssh.pslssRPSFNRTPhGWhspt....h............lshssEo--L	....................................s.pp+t.s.tlhh-lp................thsLGKKlSlP+DlMLEELSLhoNRGS+hFchRQ+Rs-KahaEs.............hpsps..h.s.....p..h......p..p.hs..ssp................................th......ut...t.......s.s.....ssss.tt..........sspshuPG..usshpthP...............................................scchppsslsKsYhSPWc..pAh.usc.phhtsht.ch.t....p.phscY+SFNRsAhPFGGhppusph..hp..hphPc........s...h.h.p.lstRPSFNRss.GWlsp............................................................................................................	0	4	15	40
+5385	PF05557	MAD		Mitotic checkpoint protein	Moxon SJ	anon	Pfam-B_7761 (release 8.0)	Family	This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated [1]. 	30.20	30.20	30.50	30.50	29.30	30.10	hmmbuild  -o /dev/null HMM SEED	722	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.47	0.70	-13.42	0.70	-6.44	5	348	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	251	6	232	343	4	476.80	20	85.32	CHANGED	DDlcssTTshhst.ts.SplRSths+FLussLcuot.sLusSss...............suuSLpKQsppShsppc.........cAEpI+oKupLIQlEpEltptELcHKRAplELE+cuossA-pYE+Esc+NpELps+lKsLcEpEsshcschpEspEct+th+pKl.........DtsopKLppEKpDptp-A+-sluslsuclSEhQhpA.st-splpsLEoEhp-L+EQLEppp++h.......sEu-cKlQuLpsttsppu-pss+IKcLEpcLpphEs-stlVKo.+pcLhplPcLE+ElppL+-ENc+L+oh+csstLLcEElp-Lco+LERtEch+-clssLELEpEKLpsELpSWcsLtQshsL..sLsTP-DlSp+lstLQpc-lpLsE+ssSlsSss+pLEsopQsLQcchppssupltEt+cKpEcp+shsRRLQ++lsLlTKERDthRAlLcSYDcEpT.ostSsph.p+L.csEDllQcVcsapuchEs...pL..c-sp--lulQKc+scsLcpElchL+pQhsss-p.h..spEtssu...LRh+l-oLEuEpuRLRpEpplLEMcht+hsLpGDYshucTKVLHhSpNPuucAcppp+sslE+LQAEs-+LKcll+tLEcsssps.sDsp.ssuSplouKElA-LKKQVESAEtKpQRLKEVFpsKIpEFRcACYpLhGY+ID.l........sssopYRLTShYAEcc-DsLlFcusuSosu.MpLLEosaStolschI-lalccpsSIPAFLSALTLELFsRpT	..............................................................................................................................................................................................................................................................................................................................................................................t............................................................................................................t..............................................................t......t............p...........t.................t..p...........tt....h.....................t...................ht.....t...............tt................................................................................................t...p..t.hpt..tt.....hlppp..t.ptp......ht......p.................th...t.php...h.tph..t.h........h.t....t........s............................s....s...............t...l................p.......h.............t...p.p.h.h.htp.st.hp........p.......htt.......hp....ptht...ph...t...p.h.........t....t.h.p.........p....................t......t............t......................p..t...........h..t...cl...ppph.lh.cEhchh.+....t...ltt..h...p.t......p....t........t.......t...................................tt....p.hpt...........t............................h.....p.h.....t.....h........p..t......t............t....t......tt.............t.t....................h..p.tplptp..........pthpp..pht........hp...p...l..t..p..............................t...........tph+lLp.hp.sPh...t.....t....p.php.LptE...tp.L.h..t.l.......t..........t..........t..........................t.h..............h......................................t....................h.....tph.c.tp...l..t...p...h...p....h+..pR......LK...pla...pt+..p-F+..csshtlh.........Gaplc.h...........hsp........s...p.h+lpSha.......................t.....p......p...p.............l...h....p..h.........t.....t...s................h.......................................t...h.........ht..l.t....t.phPshh.ush.shp.h......................................................................	0	80	130	193
+5386	PF05558	DREPP		DREPP plasma membrane polypeptide	Moxon SJ	anon	Pfam-B_7798 (release 8.0)	Family	This family contains several plant plasma membrane proteins termed DREPPs as they are developmentally regulated plasma membrane polypeptides [1].	23.20	23.20	27.30	25.70	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.45	0.70	-4.47	7	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	20	0	18	49	0	185.70	48	97.38	CHANGED	MuYWKoKVLPKIKKlF.-KsG.sKKAAAAEhpKoFD-uKEthsKEFE-KKsELQPKVlEIYEAussEIKsLVKE..c.uGlKKpostVpKFl-ELsKIEFPGuKAVSEAsuKhGPuhlSGPlhalhEKVSTFls...pEpK.cEts............sAspspsptps........tscEK-lVlE.EcKKEEtAsPs.........ts.ss...-.t.tcc.spsssAsA..sEP.Ks	.......MuYWKoKVLPKlKKlF.-Ksu.sKKA.AA.AEhhKoFDEuKEplsKEhEEKKTELpPKVVElYEAussElK.sLlK-..Ksuul.KKNSsuVpKFL-ELsKI-FPGuKsVSEAsuKhGsuhluGslhFlhEKVusFlP....cE.K..tcE...s..............sA.sptpptp.s................tspEKc.hsE..EtKccEtsss.s.................ttts.ss.s.s-tt.....tc...tt..tssss....stP.K...............	0	2	8	13
+5387	PF05559	DUF763		Protein of unknown function (DUF763)	Moxon SJ	anon	Pfam-B_7805 (release 8.0)	Family	This family consists of several uncharacterised bacterial and archaeal proteins of unknown function.	20.00	20.00	22.00	63.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.11	0.70	-5.48	30	177	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	170	0	106	193	49	316.90	44	82.83	CHANGED	GsA-LPLHsG+VP.WLhpRMp+LupsIs-lllcEYGscclLcRLucPhWFQuFusllGMDWcSSGoTTsshGsLKcsLs..sc-.lGlhVsGGKG+putpTPcELptlu-+hsLDu...ppLspsSRLsAKVDssslQDGapLYpHsFllo-cGcWuVlQQGMNscp+hARRYHWhust..psFsppPHsuIsG.hppstlLNlss+cuccsRcshl-LlpE.sPs+.lhpphpphhshhp............................h.h.tt+.lhtpslshchhtpsLptshEhsPpcFc-lLhlpGlGPpTlRALuLVAElIYGsPssapDPs.......+auaAhGGKDGhPaPV	................G.ADLPLHsG+VP.WLhpRMp+LuthIschllccYGtcclLcRLucPhWFQuFusVhGMDWcSSGhTTsshGALKcuLs...sp-lGlhVsGGKG+pSRpTPpELhtlu-phulDu...ppLspsSRLsAKVDssAlQDGapLYhHuFlloccGcWsVlQQGMNscp+hARRYHWhup......th.ps..FlppPHsuIsG..hppsp.ll...NLss+cuttsRps.l-Llp-.sPs+.lhpph.ppltsh.t.......................................................................thhhPsc+plhtp...s...lsh+c.lt..tsLtts.hEtsPpsFc-LLhl.GlGs+TlRALALVAEllaGsPspapDPs.............+FSaAhGGKDGhPaPV..........	0	43	68	83
+5388	PF05560	Bt_P21		Bacillus thuringiensis P21 molecular chaperone protein	Moxon SJ	anon	Pfam-B_7820 (release 8.0)	Family	This family contains several Bacillus thuringiensis P21 proteins. These proteins are thought to be molecular chaperones and have mosquitocidal properties [1,2].	25.00	25.00	367.20	367.10	23.80	17.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.22	0.71	-4.90	2	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	0	0	11	0	182.00	93	99.96	CHANGED	.sENtsFYKIFThcNNNhChNsTLLE+lFKNNl-EFDFSLVKpNLEHEKNCVITSTMNQTI.FENMNSpEMGpKsYSFhNQTVLNNKGNoSLEEQlSsIF.RCVYMpstKSSSYIK.LEQD.NplchhsSLlFIsPY+pNlh.IhPVsLpLTLlsKNVKpsS.pNlFSGDhHFNMVTMTaLT	MTENGVFYKIFTTENNNFCINPTLLERVFKNNLDEFDFSLVKKNLEHEKNCVITSTMNQTISFENMNSTEMGHKTYSFLNQTVLNNKGNSSLEEQVSNIFYRCVYMEVGKSSSYIKPLEQDSNKIRYVCSLLFIVPYKNNITSIIPVNLQLTLLSKNVKQSSSTNIFSGDIHFNMVTMTYLT	0	0	0	0
+5389	PF05561	DUF764		Borrelia burgdorferi protein of unknown function (DUF764)	Moxon SJ	anon	Pfam-B_7823 (release 8.0)	Family	This family consists of proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).	25.00	25.00	58.90	58.80	21.90	16.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.12	0.71	-4.85	2	127	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	28	0	12	99	0	175.50	65	97.09	CHANGED	MIlsLsp.lpaLI+IhpsFKhYh..pphEh-IlNTYNHPYLpKhsTsosNllsLK.-uhEtLhs+s.+sts.hcph.EFplpFplYhlshVL.pt.hDu.pphhhlYthh.-FLHpphaKaphppp.ps-.h.hlsaYlh.hSNhpssGLlslushauNhsaShs.hF...VtsIplLKpE+	...MIhTLDhlLNHLhpIFKGFKAYATENNFECDIINTYNHPYLSKITsuSSNIIALKFDGTEsLFDHNsRuGsFYENALEFSlNFQIYIIAIVLNApDFDANSRMLhLYuMLS-FLHN+.s.HKYTLtpp...QP-YlsKINFYIYPhSNMQTVGLINLGTKYSNHAYSASlAFNASVKsIEILKEE.h......	0	8	8	8
+5390	PF05562	WCOR413		Cold acclimation protein WCOR413	Moxon SJ	anon	Pfam-B_7803 (release 8.0)	Family	This family consists of several WCOR413-like plant cold acclimation proteins.	25.00	25.00	45.40	25.20	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.16	0.71	-4.76	15	123	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	37	0	50	124	0	164.80	42	87.45	CHANGED	LsMKo................stsussllsSDhcELssAA......+KLAsH...AlpL.....uuLGFGso...hLpWlAshAAlYLLlLDRTNW+TNhLTuLLVPYIFhoLPollFshlRG-lGpWIAFlAlllRLFFP++FP-a....LELPuuLILLlVVAPslhAsphRso..hlGssIsLsIuCYLLpEHI+uSGGF.+sAFs+usGVSNolGIllLh	.....................................................l.tchpthhhus......cphusp....shhh.....suh.shuss...hLpWlushAAlhLLllccstW+..TshhsuLLVPYlhhphPsslFshhRG-hGp..WlAFlAlllRLFFsppFPs.....LELPsu..hlLLllVAPphhssh.Rss..h..hGshlsLhIusYLl.pHlptuGGh.+puFspupslussluIhll....................	0	11	35	43
+5391	PF05563	SpvD	Sal_SpvD; 	Salmonella plasmid virulence protein SpvD	Moxon SJ	anon	Pfam-B_7864 (release 8.0)	Family	This family consists of several SpvD plasmid virulence proteins from different Salmonella species.	25.00	25.00	150.00	149.90	18.60	17.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.49	0.70	-4.83	3	25	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	15	0	1	12	0	202.20	98	100.00	CHANGED	MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYIHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD	MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD	0	0	0	1
+5392	PF05564	Auxin_repressed		Dormancy/auxin associated protein	Moxon SJ	anon	Pfam-B_7941 (release 8.0)	Family	This family contains several plant dormancy-associated and auxin-repressed proteins the function of which are poorly understood [1].	25.00	25.00	25.70	25.00	24.00	22.40	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.94	0.71	-3.50	21	211	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	59	188	1	110.90	35	91.34	CHANGED	LWDDlVAGPpP-p.GLGKLR.+hosps..lslpt.s-up................sus..hpRSlohss..................sPsoPsTP..oTPs..oP.ouR.p.-NVWRSVFpPGSN.uT+shGuphFDKPspPNSPTVYDWLYSs-TRS+HR	.......................................................LWDDsVAGPpP-p.GLGKLRKh.ohps.....shp...stut..........................tps.thp+Slsh.p........................sPsSPu.ss....ooPs........oP..h....o..sc....c.pps.....WRshh.pss..p..t.tpt.t.usph..pp.s...tPpoPTVYDWh..........................................................................	0	13	38	49
+5393	PF05565	Sipho_Gp157		Siphovirus Gp157	Moxon SJ	anon	Pfam-B_7948 (release 8.0)	Family	This family contains both viral and bacterial proteins which are related to the Gp157 protein of the Streptococcus thermophilus SFi bacteriophages. It is thought that bacteria possessing the gene coding for this protein have an increased resistance to the bacteriophage[1].	28.60	28.60	28.90	28.60	27.50	28.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.88	0.71	-4.66	29	450	2009-11-04 11:20:49	2003-04-07 12:59:11	6	1	390	0	49	359	53	153.40	29	97.10	CHANGED	hpLYELsspatplh.phhpp...hDs-tltDTL-u..lppsh-sKs-shsplI+sl.......-uDscslKtEtcRLt-++Kuh-sclcpLKsYLtptMptsshc+l+s..shholulpKstsuVpl..--stlPscYh.....ts.KlDKpsltc.....sLKsGcclsGApLcpsc.sLpIR	.....................................pLY-Lsspatpl.................p...........h-s...-..h....l....t..D..T.L-u.......lpsphcs....Ks-shsphl+sh.......puchc.hhcpEh+RLp....p....++.c...shpspscpLKsY.......LtptMpts......s..hc.....+l.cs....shhplsl.p.Ks.s..S..l...pl.....hD....E.........sh.l....Ptcah.........ppp.+hDKptltc.....sL.K.s.GpclsG.AcLhp.sc..sLhI+........................................	0	14	28	36
+5394	PF05566	Pox_vIL-18BP		Orthopoxvirus interleukin 18 binding protein	Moxon SJ	anon	Pfam-B_7955 (release 8.0)	Family	Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasises the importance of IL-18 in response to viral infections [1].	21.60	21.60	22.30	22.20	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.74	0.71	-4.12	2	55	2009-09-10 15:00:19	2003-04-07 12:59:11	7	1	18	1	0	49	0	123.30	86	99.62	CHANGED	MRILFLIAFMYGCVHsYVNAsEhKCPNLsIVTSSGEFhCoGCVcaMPpFSYMYWLAKDM+SDE.sKFIEHLG-GIKEDETlpThDGtIsTLpKVLHVTDTNKFspYRFTCVLTTlsGVSKKNIWLK	..MRILFLIAFMYGCVHSYVNAVETKCPNLDI...VTSSGEF+CSGCVEHMPcFSYMYWLAKDMKSDEDTKFIEHLGD.GIKEDETVRTpDGsIsTLpKVLHVTDTNKFAHYRFTCVLTTlDGVSKKNIWLK........	0	0	0	0
+5395	PF05567	Neisseria_PilC		Neisseria PilC beta-propeller domain	Moxon SJ, Bateman A	anon	Pfam-B_7966 (release 8.0)	Domain	This family consists of several PilC protein sequences from Neisseria gonorrhoeae and N. meningitidis. PilC is a phase-variable protein associated with pilus-mediated adherence of pathogenic Neisseria to target cells [1].\	 This domain has been shown to adopt a beta-propeller structure [2].	21.10	21.10	21.70	21.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.18	0.70	-5.40	9	608	2012-10-05 17:30:42	2003-04-07 12:59:11	6	13	415	2	192	644	232	326.40	25	29.43	CHANGED	LGDIVNSPIVAVGt.....YLA........................TSANDGMVHIFKps.GuDcRuYNLKLSYIPGTMPRKDIpN.....p-STLAKELRsFAEKGYVG..DRYGVDGGFVLR+l..-.stQcHhFMFGAMGhGGRGAYALDLoKhDuN.P..ssssLF.....DVKcs...spNGpNRVc..LGYTVGTPQIGKTHNGKYAAFLASGYAoKc.IsSssNKTALYVYDLEs.sGT..lI+KIEVPGGKG...GLSSPTLVDKDLDGTVDIAYAGDRGGNMYRFDL.....SsssPsp.........WSVRTIFcGT..KP.............ITSAPAlS+LKDKR..VVIFGTGSDLSEDD..Vsss-tQaIYGIFDsDT..GT..sospsGpGsGLLEQsL..spEsKTLFLoshK	...........................................................................................................................................hGDllpS.........h..hs..s.....................hhh...........................................suANDGMlHhF.................s.....s......s.............s.......t.....................p............p....t.hu.....al.......P..................................p...sl.ht....p.....L....t......t..h...s....p..t....s......a.......t...........cp..Y.hV....D.G...s........s..h..............t....c..s................th.s.s................s..........h+.....shlhGuhstG...............G....+.............u..............h..............aAL....DlT...........t...................s..s...........s...s.h...t...hh....................................p.h.p...s.s.................t....t.....s...s..p.......LG..oh.u...p.P...............l........s........+.............h.............p............s......G...........p...........a....s..........s.......l.h..GsG......Y..........s.........s.......t..s.............................................................s....p......s..........u..........L............al...l...c........h.................p............s.....................Gs..............h...........l........t......p....l.........s....s....s..s...u....ps................G.L.....u...s....s..........s...l..l.....D.......p.............s....s..D.G...h.s.....D......h.....s...Y.......A...G........D.......h.....t.......Gsl.......WRF.D.l...............ss...s...ss.ss.................................h.s...h........t.................h.....t...s.........pP........................................Io.st...P....l............h............s...t..h.................h.l.h.h.GT.....G....p.........h....t..t.tD..........h...s..p...t.p.....thYul...h..........D..t.tt......................................................................ht............................................................................................................	0	41	123	162
+5396	PF05568	ASFV_J13L		African swine fever virus J13L protein	Moxon SJ	anon	Pfam-B_7998 (release 8.0)	Family	This family consists of several African swine fever virus J13L proteins.	20.80	20.80	20.80	23.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.41	0.71	-4.76	2	103	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	12	0	1	95	2	169.90	80	100.57	CHANGED	MDSEFFQPVYPRHYGECLSssssPSFFSTHMYTILIAIVVLIIIIIVLIYLFSSRKKKAAAAIEEEDIQFINPYQDQQWutVTPQPGhuKPAGAoTuSAGKPVhsRPsTN.....+PsTN+PVhDp.sMAsGGPtAASAsA........aPAE.YTTsTTQNTASQTMsA.ENLRQRsTYTHKDLENSL	.............MDSEFFQPVYPRHYGECLSPVosPSFFSTHMYTILIAIVVLlIIIIVLIYLFSSRKKKAA.A.AIEEEDIQFINPYQDQQWAEVTPQPGTSKPAGATTuSs....GKPV.TGR......P.....ATNRPss.....s+PVT.....sN.....PV..........TDR.....LVMATGGPAA........AsAAA..................sAHPsEPYTTVTTQNTASQTMSAIENLRQRsTYTHKDLENSL...................	0	0	0	1
+5397	PF05569	Peptidase_M56		BlaR1 peptidase M56	Studholme DJ	anon	Merops	Domain	Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein       and a transcriptional repressor.  The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains.  The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. Homologues to this peptidase domain, which corresponds to Merops family  M56, are also found in a number of other bacterial genome sequences.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.98	0.70	-5.45	12	1807	2012-10-03 04:41:15	2003-04-07 12:59:11	6	87	857	0	421	2510	322	241.60	19	47.77	CHANGED	hhlhthslssshslLllhllRhhl++hhushhsYtlWhlV.lthlhshh...............tsshthshspsPhstsssp.............shstsh.thshtslh.hL.hllWlsGsll.....htuhhhh+pp.hl+phs.hps....phLttstcpht...............sPhlhGhh+PpIllPssh..phsscEhchIlhHEhsHl+RtDhhhNhlsshhpslhWFNPllaluh+thchDpElACDtsVLst.ppcpR+pYucslLpshhusss..sshssph...sppsL+cRlhhl	.....................................................................................................................................................................h...........................................................................................................................................................................................................................................................................................................................................h.................h...h....h....h........l.W.....l.h...h...h.....h..h..h.....h..h...h..h...h....s..hh.......h...t..................h......h..t....................h...........t....................t..hh............t........h..................p...ht..........................h..........l...h.........s....t....t....l.....t...s...P.....h..h......h.......u....h......h......c....s....h....l.l..l.P....p.t.............ph.....s..p.p.c.l....c.hIlhHEh......sHh.+.p.+D........h.l.hhh..l.....h.t.l....h..t.....h.l.h........W.F..NPh...l..a.hhh...pphppspEhtsD.ctVl........p..p.........t........p....p.tt....p.Yupsll....p....h..s...h..t.t...s.h..........................h..h...s....t..................tpp.lKcRlh...............................................................................	0	214	340	394
+5398	PF05570	DUF765		Circovirus protein of unknown function (DUF765)	Moxon SJ	anon	Pfam-B_8063 (release 8.0)	Family	This family consists of several short (27-30aa) porcine and bovine circovirus ORF6 proteins of unknown function.	25.00	25.00	63.70	63.60	17.10	16.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.94	0.72	-7.27	0.72	-3.98	3	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	0	10	0	28.70	94	99.73	CHANGED	MASSTPASPAPSDILSSlPQSERPPGRWT	MASSTPASPAPSDILSRLPQSERPPGRWT	0	0	0	0
+5399	PF05571	DUF766		Protein of unknown function (DUF766)	Moxon SJ	anon	Pfam-B_8021 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	25.00	25.00	26.10	25.70	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.29	0.70	-5.13	5	128	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	91	0	77	117	0	262.90	52	91.77	CHANGED	ChGLYCGRTLLtsNSSp-h.....YS-CGACPRGpRoNsQphCsPCp-sLptYDWLYLGFMAMLPLllHhFFI-hstKs.pKpS+uplhpalSAllEsslAAllTlLlo-PlasL+IpSCcVphLSDWYThhYNPSPsYpTTV+CTQEAVYPLYTIVFVaYhFCLVhMhLLRPlLVsKI...LsVus+hK.ulYuALYFFPlLTlLHAVuGGLIYYuFPYIlLVlSLVuhAlHhSh.Kl-pohKsLl++.shp.++lllLhuHWLLLAYGllSL.ps.plcYDluLLs..LVPsPsLFYlFTlKFT-Pu	.....C.GhYCG+sh..L.pss...............au-CG...sCPRGpRs.....Ns.pphCpPCs-sPphYDWLYLGFMAhLPLlLHWF..F.I-h...........hs...tK..pSpssLhpHloAlhEsshAAllTLLls-PlGsLhlpSCcVhh...LSDWYThLYNP.SPcYhsTl........HCTpEAVYPLYTIVFla..YAFCL.V.hMhLlR.P..lLl.pKl........Ls.+ss+....hK....SIYAALYFaPILTllpAVuGGLlYYuFPYIllllSllohAla.hSh..clcp..shc.............Lltp.........Kpl.llLhuHWLLaAYGIlSls..............php..p..hp....c...hshLs..LVPhPuLFYlhTs+FT-Ps................................................................	0	27	32	56
+5400	PF05572	Peptidase_M43	Peptidase_M46; 	Pregnancy-associated plasma protein-A	Studholme DJ	anon	Merops	Family	Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II.  Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.62	5	563	2012-10-03 04:41:15	2003-04-07 12:59:11	8	39	269	10	378	715	221	143.40	28	22.67	CHANGED	sspscsItsatW...DNpKYMNVaIQs-L.ssGuTsNSGsAWYPcoGMos-slARVsFNGtYLus...ssoSosFuuoLTHEFGHFLGLcHTFcGG....CccGsup......DcssDTPspsutch....usspslhN......CsG-hlNspNaMDYNs...CpsMFTQsQVsRMsssL-	................................................................................ttshth..............................................................................................................................................................................................................h.........h.....................h.......................h..........s.....h.....u.....p.....Ths..HElGHaLGLaHs...F..ps.s...............Cs.s......ht.......................Dh.l..sD.T...P.sp...s...p..s..p...s...........ss..s..t.s.h..ss...........................C..s..s...t......s....h............h.......p....NaMD..YosD.....sC.h.....s..p.F..TssQhsRMpt...t..........................................................	1	151	254	320
+5401	PF05573	NosL		NosL	Moxon SJ	anon	Pfam-B_8116 (release 8.0)	Family	NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallo-centre assembly [1].	20.20	20.20	20.20	20.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.84	0.71	-4.50	50	701	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	544	2	243	576	51	139.30	25	73.14	CHANGED	hhhLuuCscppss..t.s.sshplsspspC+hCGMhls-aPGPKuQlhhput..ps....haFsss+Dhauahh.....pPEps.+plpAlaVpDMup..ssWppPss....ppaIDAc......pAaYVhGSsppGuMG.splssFuscssAptFAsca.GGpVlpFc-Is.shl	........................................................................h...h.uCt.tttt.......s.htl.p.p.p.s.hC.t.hCsMsl..h..-..hs..t.tuplh..h....pss....cs...........hhFss.ht.shhtahh......................s..c....p.........s......c....p...h.ptlaV.pDhss..............................tpaI-Ac..........cAhYV..hsos.....h.h...u....s....M...G..shlsFusc.p.sAcpFspp...p....G...G+......lls.ac-ls......................................	0	66	185	221
+5403	PF05575	V_cholerae_RfbT		Vibrio cholerae RfbT protein	Moxon SJ	anon	Pfam-B_8029 (release 8.0)	Family	This family consists of several RfbT proteins from Vibrio cholerae. It has been found that genetic alteration of the rfbT gene is responsible for serotype conversion of Vibrio cholerae O1 [1] and determines the difference between the Ogawa and Inaba serotypes, in that the presence of rfbT is sufficient for Inaba-to-Ogawa serotype conversion [2].	27.90	27.90	27.90	28.00	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.81	0.70	-5.35	2	55	2012-10-10 17:06:42	2003-04-07 12:59:11	6	1	34	0	2	97	69	238.30	95	99.24	CHANGED	MKHLIKNYVQKLIKTELDAIQSKSVHDNRNFIYNGEFLILESEFGhHCFPRVQLNHALSYKNPNFDLGMRHWIVNHCKHDTTYIDIGANVGTFCGIAARHITQGKIIAIEPLTEMENSIRMNVQLNNPLVEFHHFGCAIGENEGENIFEVYEFDNRVSSLYFpKNTDIADKVKNSQVLVRKLSSLDISPTNSVVIKIDAEGAEIEILNQIYEFTEKHNGIEYYICFEFAMGHIQRSNRTFDEIFNIINSKFGSKAYFIHPLSSAEHPEFNKATQDINGNICFKYVS	..................................................MKHLIKNYVQKLIKTELDAIQSKSVHDNRNFIYNGEFLILE...SEFGWHC.FPRVQLN.HALSYKNPNFDLGMRHW.....IVNHCKHDT..TYIDIGANVGTFC.GIAA.R.HI.T.Q.G.KIIAIEPLTEMENSIRMNVQLN..N..P.LVEFHHFGCAIGENEGENIF....EV.....YE...FDNR......VS...SL.YFQK.NTDIA.....DKV...K.N.S.QV.LV..R..KL.SSL..D..I.......S..P..TNS..V..VIKIDAEGAEIEILNQIYEFTEKHNGIEYYICFE....F...AMGHIQRSNRTFDEIFNIINSKFGSKAYFIHPLSSAEHPEFNKA.TQDINGNICFKYVS...................................................................	0	2	2	2
+5404	PF05576	Peptidase_S37		PS-10 peptidase S37	Studholme DJ	anon	Merops	Family	These serine proteases have been found in Streptomyces species.	19.50	19.50	19.50	19.50	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.67	0.70	-6.03	2	98	2012-10-03 11:45:05	2003-04-07 12:59:11	6	1	87	0	31	179	5	421.20	41	91.66	CHANGED	AEPKAVDIKDRLLSIPGMSLIEEKPYTGYRFFVLNYsQPVDHRHPSKGTFQQRITVLHKDVNRPTVFYTGGYNVSTNPSRREPTQIVDGNQVSMEYRYFTPSRPAPADWSKLDIWQAASDQHRIFKALKPLYS+NWISTGGSKGGMTATYYERFYPRDMDGVVAYVAPNDVVNKEDSAYDRFFARVGTDECRDKLNGVQREALVRRAPLEKKYAAYAAENGYTFDTIGSLDRAYEAVVLDYVWGFWQYSTLADCADIPADAKNATDDAIWGSVDAISGFSAYTDQGLETYTPYYYQAGTQLGAPTIHFPHIEKKYIRYGYQPPRNFVPRSIPMKFEPWAMRDVDTWVRHNARHMLFVYGENDPWGAERFRLGHGARDSYVLTAPGMNHGANVAGLVPDQKARATARILDWAGVAPAKVQENPSAARPLATFDARLDQRDVEREPALRP	................................................................sst......Dlpc+L.ulPGhohlc.c...h...........s..uY.R.h...aVlpa.sQPlDH...+....+....P...p.p.GoFpQR.....l...hl....h...H..........+.....s....h....s....R...P...T....V..hh.TpG.....Y.s......s....u.......h.....s...P..p....h...p........E........o.pL.....l.......s.....uN.p.....lslEYRaFs.SpP......p....P....t......D.........W....s.....h.......L...o...lh.....QuAsD......H...+..lh.p.A.h..K....p....l.Y....s...t....+.........W...luTGhSKGG.TuhaYRpFaPcDlDsoVsY.V.AP...s.h.h.s.t.EDu..ta....-.t.F.h.......p.p....VG.T............t......-..............CR...c+l..pshQ..h..EsLhR+ss.......Lls+a.cp..ausppshTFc.hlGsl-cuaEhsVL-YsFuFWQau.s.s.s.Cs.s...IPu..tsAoDcpLasalssISuh.s.hasD...p...uhtsYssaaYQAuspLGh.shch.sa.h.cth..l....c....h....Gh.p.......sR.a.l......Pcpl..s..M.c.....F-.shhpclcpWl+csup+MlFlYGpNDPWoApshphhc.G..t+.spa.VastPGusHs.AplusLsts.p+tpAhutltcW....................................................t.........................................................................................................................................	0	13	22	29
+5405	PF05577	Peptidase_S28		Serine carboxypeptidase S28	Studholme DJ	anon	Merops	Family	These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.45	0.70	-5.91	12	1264	2012-10-03 11:45:05	2003-04-07 12:59:11	7	20	253	9	917	1384	70	339.30	23	80.92	CHANGED	QpLDpFcsssscoapQRYahNspahpss..uPlFLhl...GGEushssthltss..thhphApcaGAhVh.LEHRFYGpShPhsshost.sl+a...LoSpQALtDlApFIpshs..phphtsss.WIsFGGSYuGsLuAWhRthaPcLlhGulASSuPlhAplDFh...EYhpVVtsSlpphus....p.ChsslppuFsplcpLhtospGppsl..ppthphssshspt...s-.pDht.hatslhu.atulVQYs..hDspss.shs.hslpphCphhh......ss......oss..s....hshhh.l.pphstt...shshtpsshsh.hhss...phpssu.....hts.sRtWhaQTCoEaGaaQosss....stthFusshPsshal.chChslFGsshspp.lptslttTN.h..YGG..p.suoNVlhsNGslDPWHsLG..htssssuollshlIpusuHCsDMhsspsuDsspLpsuRphl	...................................................................................hDp..........s....................p.............tpa.....p...RY.h.h..s..t..p..a.a...p...............s............u.......P.l......hhhh..........usE...s.........s...h...t.........h....h.......t..ps..........hhh.p......hAt.....phtuhhlh...h..EH.................RaY...G....pS...h......P...........h............s..........s............s......h......t.....p..........lpa...................LospQA...............L..sDhs..hh....p...............t........h..........p.........t................p.......h..............................t..............t......s.....s..............hlhhGG...............SYuGh..............Lu...AWh...........Rhp........YPc..l..hh.................uulAo.Sus..l..............t......h.......h.......s..h...........ta...h.p..lt...psh....s...................p..C.ttl.ptsh.....p..l..p.p.h.h........t..p...........t..t................ttl...........tp.ht.....h..s..........h..p................p.........................h..................................t..h..h.......pa.............................................................ht.........h..Ct..h..........................t....................................................................h.......h............h.........................................t.............................................t.......................s....ttW..aQ.sC.s.E..h....s....h..........s..s...ss...................t...h...h...s..p....h..s.....h...p....h..h....p.C..............ph....a.............s........................................................t.....h....s..............a.G.u..............................t......s...s....p...lh....a...ss...............G..hDPW.....p........h.........u..........h..........p........t........................s.................p...............s..........h......h..h......t..s.............s.Hp....Dh.......................................................................................................................................................................................................................................	0	328	536	770
+5406	PF05578	Peptidase_S31		Pestivirus NS3 polyprotein peptidase S31	Studholme DJ	anon	Merops	Family	These serine peptidases are involved in processing of the flavivirus polyprotein.	20.50	20.50	22.60	25.00	20.40	18.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.32	0.70	-5.13	4	226	2012-10-02 13:45:52	2003-04-07 12:59:11	7	34	30	0	0	244	0	175.10	90	7.31	CHANGED	GPAVCKKITpHEKCHVNIhDKLTAFFGlMPRGTTPRAPVRFPTuLLKVRRGLETGWAYTHQGGISSVDHVTsGKDLLVCDSMGRTRVVCQSNNKhTDETEYGVKTDSGCP-GARCYVLNPEAVNISGoKGAhVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNE-SKPTKLMSGIQTVSKNpADLTEMVK	..GPAVCKKITEHEKCHlsIhDKLTAFFGlMPRGTTPRAPVRFPTuLLKlRRGLETGWAYTHQGGISSVDHVTsGKDLLVCDSMGRTRVVCQSNNKhTDEoEYGVKTDSGCP-GARCYVhNPEAVNISGoKGAhVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNE-SKPTKlMSGIQTVSKspsDLT-MVK......	0	0	0	0
+5407	PF05579	Peptidase_S32		Equine arteritis virus serine endopeptidase S32	Studholme DJ	anon	Merops	Family	Serine peptidases involved in processing nidovirus polyprotein.	24.70	24.70	24.70	25.10	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.86	0.70	-5.44	6	275	2012-10-02 13:45:52	2003-04-07 12:59:11	8	13	15	6	0	344	2	299.70	70	11.60	CHANGED	LThlWVpFF.....LlsVshhAGVsulslLlshWhLuRhTslsGlVTPYDlHhlTuoPRGu.....uulAoAP-GTYLAAVRRuALTGRsthFlPoshGSVLEGuhRT+psutNsVsVhGSohGSGGVFTIsGpsVVVTAoHVLu.sspARVossGasppLsFKssGDYAhAcs..ssWpGsAPplchu.pshpGRAYWpssoGlE.GllGpssAFCFTsCGDSGSPVlsEDGpLlGVHTGSNKpGSGhVTTPsGcTluhuslKLSEhupHauGPtVPlusl+LPcplIsDVcuVPSDLsuLl-SlPslEG	.................................................................................LTILWLVFF.....LISVNhPSGILAlVL...LVSLWLLGRYTNlAGLVTPYDIHHYTSGPRGV.....AALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSLLEGAFRTpKPSLNTVNVVGSSMGSGGVFTI.DGKlKCVTA.AHVLT.GNSARVSGVGFN...QM.LDFDV..KGDFA.IADC..PNWQGsAPKsQFCpDGWTGRAYWLTSSG........V......EPGVI.........GsGFAF.C.F.TACGDSGSPVITEAGELVGVH.TGSNKQGGGIVTRPSGQFCNVcPIKLSELSEFFAGPKVPLGDVKIGSHIIKDssEVPSDLCALLAAKPELEG........................	0	0	0	0
+5408	PF05580	Peptidase_S55		SpoIVB peptidase S55	Studholme DJ	anon	Merops	Family	The protein SpoIVB plays a key role in signalling in the final sigma-K checkpoint of Bacillus subtilis. 	21.70	21.70	21.90	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.18	0.70	-4.89	6	510	2012-10-02 13:45:52	2003-04-07 12:59:11	7	3	487	0	114	438	11	195.60	43	45.24	CHANGED	hpc.Ku-upY+IGLWVRDSsAGIGTLTFY-PpoKKYGALGHsIoDsDTp+llslcsGpIlcSolsSIcKGspGsPGEl+GhFss-pcsIGslppNophGIFGshppc......hsNhpspsl.Vuhps-VK.GPAcILTsIDscplcpaDIEIVphs.QcuPssKuMVIKlTDs+LLccTGGIVQGMSGSPIIQNsKllGAVTHVFVNcPssGYGlaIEWMLc-	...............................t...tptpY+lGLalRDssuGlGThTFhcspstpaGALGHsIoD..D.Tt.p.l.lpsGplhposlhuIc+GppGpPGEhhu.h.a....p.p.p.h.lGsIptNo.hGIaGphppt............t...h......pcsh.lAhpppl+pG.s.A.p.I.l.Tslcs.p.clcpF-IEIhplh.pptsusKuMl.I.+lTDtcLLpcTG..GIVQGMSGSPI.lQ.sGKllGAVTH..V..F.V.N.D..PspGYG..la..IEhMLp......................	0	64	95	101
+5409	PF05581	MCP_N	Peptidase_S38; 	Vibrio chemotaxis protein N terminus	Studholme DJ	anon	Merops	Domain	This domain is found at the N terminus of several methyl-accepting chemotaxis proteins from Vibrio species.	21.40	21.40	22.10	21.80	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.26	0.72	-3.87	2	277	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	155	2	39	173	3	101.50	42	16.53	CHANGED	M+FSpKIVAASSsLLLsslALLShpQh.pVR-EIcShVpDSl.EhVcGVppThtpslsu+KulAQ.sTpllp.sPp..s.s+ollppP.lKsoFLhlGhGhEp	...MKFSHKIVsASShLLLsTlALLShpQhhplRsEIcshVpsSlpEhlcGVpsTlps.lsu+KuLAppsTpllphcPs..shlcsllppPhlKsoFLhlGhGhEp........	0	8	13	28
+5410	PF05582	Peptidase_U57		YabG peptidase U57	Studholme DJ	anon	Merops	Family	YabG is a protease involved in the proteolysis and maturation of SpoIVA and YrbA proteins, conserved with the cortex and/or coat assembly by Bacillus subtilis.	25.00	25.00	26.50	26.50	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.91	0.70	-5.44	25	309	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	285	0	73	206	2	268.90	49	98.65	CHANGED	hclGDlVsRKSYspDIhF+II-Icp.tpstchslL+GlchRLlADAPhcDL.hlcpschpc..pc+phppchpcsl+plhpctp............hhcpcpphpsssshppptphFphPG+VLHlDGDs-YLchCLclYcpLulsshGhtlpE+-QPcclhsLlcca+PDIlVlTGHDAhh...KsctshpDLssYRsS+YFlcoV+pAR.+apPshDpLVIFAGACQSpaEullcAGANFASSPsRVhIHALDPValsEKIAaTsls-sVslp-llcNTITGtKGlGGlETRGKhRhGhPhp.h	.............h+lGDlVsR+SaspDIhF+Il-Ict.........clAILpG.clRLlADAPh-DLhtlcpcchpcpt+p..cpphpcsh+hhppchh..............h.c..pcp.ph...p....s..st..s..hp..pp..paFphPG+VLHlDGDstYLcpCLclYpclGlss.GlpspEpE.scclhcLlcca+PDILVlTGHDuhh...Ks..c..t..shtDLsuYRpS+aFVpuV+psR.+h.PshDpLVIFAGACQSaaEALlcAGANFASSPuRl.IHALDPValstKIuaTsh.-hVslhDVlcNTITGtKGlGGlETRGhhRpGhPhp............................	0	31	58	64
+5412	PF05584	Sulfolobus_pRN		Sulfolobus plasmid regulatory protein	Moxon SJ	anon	Pfam-B_8140 (release 8.0)	Family	This family consists of several plasmid regulatory proteins from the extreme thermophilic and acidophilic archaea Sulfolobus.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.16	0.72	-4.01	6	48	2012-10-04 14:01:12	2003-04-07 12:59:11	6	5	28	0	10	65	3	69.50	40	58.43	CHANGED	hEKLTlophILlpLSt+.CtTLEcLpE+TussKphLLVhLTRhaK+GIIhRKWp+aGG+KaREYCLKhREEll	.....................p+Lp.pptI.LlhLu+t...CtTLE-LcctTsls+spLLVhLo+Lt+cGlItRcWt+.h..u.G+KaR.c.YCLK..h...................	1	2	3	10
+5413	PF05585	DUF1758	Peptidase_A16; 	Putative peptidase (DUF1758)	Studholme DJ	anon	Merops	Family	This is a family of nematode proteins of unknown function. However, it seems likely that these proteins act as aspartic peptidases.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.87	0.71	-4.69	3	313	2012-10-02 15:32:34	2003-04-07 12:59:11	7	33	35	0	292	363	0	145.90	19	16.24	CHANGED	VsVpNApGs..hTuCRLLFDSGSELSYISERCINsLGLARTPSRILVoGISusKA-sTRGsoplsIpSRlSssT.LsVpAHVLuKITSSLERpsIDsSlLsVFNDLphADopF..uolAPIDILLGSDYlWusITGpKI+DstGsLIAISSIFGWVITSltus+usoAT	.......................................................h..............htsLhDsGSphoalopp.htpt..LtL....t..t..pp....h...h.t.hh..u...t...p....p..s..p.t.tt.htph...p...l.p....h.p..h.p...s...t.t........hp....l...pshs..ls..p.....l.....s.s.pl........hsl....s..t..p.......h..p..th..t..slpl.s.-....th..ppt..tp..hDlLlGs...Dhh.hpll.ttp.h..hpt...tst.hhh.pohhGal.ls.............ssh...........................................	1	167	170	284
+5414	PF05586	Ant_C		Anthrax receptor C-terminus region	Yeats C	anon	Yeats C	Family	This region is found in the putatively cytoplasmic C-terminus of the anthrax receptor.	25.00	25.00	30.00	30.00	21.90	19.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.36	0.72	-3.53	10	141	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	37	0	79	109	0	91.80	65	19.15	CHANGED	VRWG-KGSTEEGARLEKAKNAVVpMP-EEhE.P...cPsP+ssPs+pPs.pcKWYTPIKGRLDALWALLRRQYDRVSlMRPpsGD+G..RCINFoRVps	..................VRWG-KGSTEEGA+LEKAKNAVVKhP-pEhE.P..p..sps.p.s.p+pPs.ppKWYTPIK.G+LDALWALLRRtYDRVSLMRPQsGDcG..R.CINFsR..............	0	2	10	38
+5415	PF05587	Anth_Ig		Anthrax receptor extracellular domain	Yeats C	anon	Yeats C	Domain	This region is found in the putatively extracellular N-terminal half of the anthrax receptor. It is  probably part of the Ig superfamily and most closely related to Pfam:PF01833 (personal obs: C Yeats).	25.00	25.00	25.40	36.80	22.90	20.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.33	0.72	-4.18	12	190	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	39	22	100	145	0	102.50	51	22.00	CHANGED	lp+SChEILulcPSSVCss.........EsFpVVl+GsGFppu+p.ppVlCoFphNpohohsE+Ps.slcssalLCPAPhLpcsGpshplpVShNsGhSFISoulpITuopCosG	........................c+SChEILusEPSSlCsG.........EsFQVVl+GNGFppu+ss-pVLCoFplN-ohT.l..s.cKPh.sVccsalLCPA.P..lLccsGpp..hslpVShNsGhSFISSSlhITsTcCosG.....................	0	7	16	45
+5416	PF05588	Botulinum_HA-17	botulinum_HA-17; 	Clostridium botulinum HA-17 protein	Moxon SJ	anon	Pfam-B_8286 (release 8.0)	Family	This family consists of several Clostridium botulinum hemagglutinin (HA) subcomponents. Clostridium botulinum type D strain 4947 produces two different sizes of progenitor toxins (M and L) as intact forms without proteolytic processing. The M toxin is composed of neurotoxin (NT) and nontoxic-nonhemagglutinin (NTNHA), whereas the L toxin is composed of the M toxin and hemagglutinin (HA) subcomponents (HA-70, HA-17, and HA-33) [1].	20.80	20.80	21.10	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.97	0.71	-4.31	3	33	2012-10-02 19:42:32	2003-04-07 12:59:11	6	2	16	1	2	40	0	128.20	72	92.70	CHANGED	MSAERTFLPNGNYKIKSIFSsSLYLTPlSGuLTFSNTSStNNQKWKLEYluEsNuFKISNVAEPNKYLoYNsaGFIsL....DSoSNcsYWhPIKIAlNTYIIsoLscVN.hDYAWDIYDsNsNIoDQPLLLLPNFDIpNSNQMFKLEKI	..............................MSsERTFLPNGNYpI.KSlFSs.S..L..Y..L..s.sSGuLoF.SNpSShsNQKWplEYhupspsF+hS..NVAEPNKYLuYss...aG...F.I.L.....sS.SN..pshW.PIK.IAlNoYIhhoLshVN..hDYAWsIYDsNpNIhsQPlL.LPNFDI.NSNQhhKLEKl......................................	1	1	2	2
+5417	PF05589	DUF768		Protein of unknown function (DUF768)	Moxon SJ	anon	Pfam-B_8463 (release 8.0)	Family	This family consists of several uncharacterised hypothetical proteins from Rhizobium loti.	21.00	21.00	21.40	21.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.98	0.72	-4.04	7	32	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	0	19	32	1	62.80	33	72.41	CHANGED	MSTRGIsFLccWIucplP-TstuD.llSls-LTpKLhADAKAhGItpp-I-E-suSlaphIlcAl	...MSp+u.pFLcpWIu-pl.sss.spsD..h....l....uhs-.LscchhADActtGIspp-.I.pE-s..GslhchIhpu................	0	0	13	13
+5418	PF05590	DUF769		Xylella fastidiosa protein of unknown function (DUF769)	Moxon SJ	anon	Pfam-B_8396 (release 8.0)	Family	This family consists of several uncharacterised hypothetical proteins of unknown function from Xylella fastidiosa, the organism that causes Pierce's disease in plants.	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  --amino -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.86	0.70	-5.18	6	104	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	12	0	12	77	0	212.10	35	45.08	CHANGED	PPIDSRTGKP.MMAGPWENRDLSLEYFQLDFLGQYTVKHAFINGINIDRCYPGAPPDHVQVVMMoh+sGScoPGIlsphpG+.PPpPhspoAAFIGhcKSNTosch.PcG.oVLRp.Ds.....VsthhKFssLCoAcFsGGN-..IpFGIR........SAsSpSIpuhlpstssLspAs.+......-hhusR.................sFlc.sPcTETRWGNsWTWa.+AalPoPl...GDGlEhWM.TPIGsoGYYlsVphNFhEutRQKNTEsYQRA.........RcLMDGlLQSVVIQKp	.........................................................................................................................................................................p............G.pslpp.............phs.hspA.hsGGsp..l.aGhc........suhu.ultttlpsh.thhpts........thhspp.......................................hlc.ssppEpRassshohh.+t..ss.sl...G.sGlE...hhh.TPlGs.uG..hosshphh-utt.pssc.hphA.........ppLhsGl..p.lhpK....................	0	0	11	12
+5419	PF05591	DUF770		Protein of unknown function (DUF770)	Moxon SJ	anon	Pfam-B_8473 (release 8.0)	Family	This family consists of several proteins of unknown function from various bacterial species.	20.70	20.70	21.00	21.00	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.99	0.71	-4.67	91	1558	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	971	0	276	902	48	153.90	37	85.07	CHANGED	hh..scs.tsRVpIpY-lcssuupcclELPhshhVlGDhoG....tpspsslc-R+hlslD+-NFcsVMcphsPplshpVsNpL..ss....s....splsVcLsFcShcDFsP-slAcQVstL+cLLEhRptLssLpu.hsspsshcchlpclLpssshhcpLtsEhp.ht	..................h.hucs.tsRlpIpY-lcssGupcclEL..Phshh..VlGDhuu.........tp-p.......sslp-...R.....chlsID+.cNFssVMpphsPplsas.V....sN.s.....Lt....ss.....s..............splsVsLsFcShcDFsP-slA+p..Vs.pLppLLEhRptLssLps.hsspsshcph.....lpplLpssphhppLhpcht.hh...............................	0	50	118	197
+5420	PF05592	Bac_rhamnosid	bac_rhamnosid;	Bacterial alpha-L-rhamnosidase	Moxon SJ	anon	Pfam-B_8527 (release 8.0)	Family	This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria [1].	35.60	35.60	35.70	36.10	35.30	35.40	hmmbuild  -o /dev/null HMM SEED	509	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.52	0.70	-6.29	25	1344	2012-10-03 02:33:51	2003-04-07 12:59:11	6	54	458	3	498	1369	219	462.90	20	56.56	CHANGED	lpcsssuphllDhGQNhsGalRlc.VcuspGsplpL+auEhLc............cGslt..TpsL.........RsAcsoDpYIh...........pGc.tt-........papPpFTa+GFRYVclsGh..sp.....hsss..s..........lsuhVlaSD...hccsGsFcsScshlNpLacNshWohRu.NFhulPTDCPQRDERlGWTGDspshu.sAsahaDspshhs+WLpDltssQps.s.................G....shPslsPssh.......ssssssssWusuhlllPWslYppYGDppllccpYsuMctal-alppcsss......hh.thssaphGDWL............sssspTstsll.AoAaascssphhuchAphlGpsp.....D.AccYpshuccl+pAFpscal.sssG..............plsssT.....QTAhsLsLhasLV..........Pcstp.ttssppLschlcpsst+lsTGFl..GTshLhpsLsc..sGcp-lAYclLhpcshPSWhY.lsp.GATTlWEpW-uhh.......tsstMsSaNHYu.hGulspWhapsluGlp.............sstPGa+clhlpPtPs.usLs.A........cusacosYG.cIcscWchc..sGp.hpLplplPsNosApVhL	................................................................................................................h......t.hlh.DhGpphsGhhph...p.....h.........p.....s..........t...u.......t......t......lp.hh..h....uE.....ht.......................................................t..u.p..h...........t.h........................................................h...h.h.......................t.Gt.....t...........................h....st....h..s..h...h.u....FR..Yl..p..lpsh...tt...................t...p..................lpu..h.hhhs.s............ht.....t..u..p..F.p..s..u.s..........hl.N........plap.shhs.......hp...........s.shh.....s..h.....sDC..PpR.ER..hsWhGDhth.s...s.sh.h....h..s..s..t..t..h...hpchlps.h.ts...tp....p.........s...............................G..........hh...s...t....h....h...Pt................................t.s....ssa.....s...........h...h......lhhsap...h.Yhhh.G..Dp....p...hl......pp....h.as.s...h..p...p....hl.....ca.hhp.ptss....................................h.ssh....t.h.u...DWh.................................sht.tt..s..s.t..th.....h....s..ss.h.h.h.hshph..hsph....A..p....hl.G..c.pt...................................c..sppapp...ht.p...p.l.pp...s...h...pp..p.....a..h.s..ppu.............................................tht.s......s.o............psu.......sh....ul.hh.sl.h..........................s.p.p....tt.......t.....t..h..hp......tL............h.p.h..........h........t.......t.........p............s..........h.....t......h.........s......s..G......h.h..............u.......s...al....h......p....s....L.........sp..............tGt......t....ch..s..........hph...h.......h........p....p........hss.....Wh..h.l...p......p......G....A...T...ThW.Et..a..ss..............................s.h.sShsHhh.hu..ussta.hhphlhGlp...............stpsGa.c.phhlpPt.............sslp.s...................puph.....o....s..h....G..t....lp.sp.Wph..........p.......s.........st.....h.php..lplP...s..spu.l..............................................................................................	0	220	361	461
+5421	PF05593	RHS_repeat		RHS Repeat	Yeats C	anon	Yeats C	Repeat	RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding (e.g. [1]). Note that this model may not find all the repeats in a protein and that it covers  two RHS repeats.	20.80	20.00	20.80	20.00	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.35	0.72	-3.69	203	21340	2009-01-15 18:05:59	2003-04-07 12:59:11	9	591	1319	0	3320	21290	603	38.60	28	15.02	CHANGED	YD.spGpLhs......hs.t.......ssGpss..p.ap.YD.stGp...ls....ph.....ssssGp..s	..............................................YD.ttGpLsp..........................hT..s..........................ssGpps.........p.Yp.YD..stGp...........ls............ph.........psstG...............................................	0	1007	1995	2696
+5422	PF05594	Fil_haemagg	haemagg_repeats; 	Haemagluttinin repeat	Yeats C	anon	Yeats C	Repeat	This highly divergent repeat occurs in number of proteins implicated in cell aggregation [1]. The Pfam alignment probably contains three such repeats (personal obs: C Yeats). These are likely to have a beta-helical structure.	21.50	2.30	21.50	3.30	21.40	-999999.99	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.60	0.72	-3.64	157	6916	2012-10-02 14:50:22	2003-04-07 12:59:11	9	294	419	0	1577	9015	69	75.00	16	36.58	CHANGED	sssGphplpss.............................................................ht.spsutlssssslslp..usshhs.ssush.stss......................................hplsusGsLsspu	.................................................................................................................................................................................................................................h..s.spsG.....t..l.t.u.s...s.s..l.sls......u.s.sl.s...s..s....G...t..l.....u..s..s...s..h..t..h..p..s..tt...ttt....................................................htlts.t.sth......................................................................................................................................	0	229	664	1231
+5423	PF05595	DUF771		Domain of unknown function (DUF771) 	Finn RD	anon	Pfam-B_7023 (release 8.0)	Family	Family of uncharacterised ORFs found in  Bacteriophage and Lactococcus lactis. 	22.90	22.90	23.40	23.40	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-10.12	0.72	-4.07	18	367	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	341	0	27	185	0	87.50	33	84.35	CHANGED	-stlllscpphp-lpptshcs.h....hsls-lp++h.s.+upshlpcpllpsP+FcKplchp....GhlhaPp.spus+.ahhps+chpcal-cpFpEIh	.........................................shllls+pEYpEL.hthshcshW...........hshs-Lc++l..p..tS.cphlpcplLhcP+acKclchp.....GhVhYPs..psts+...WpFpA++hpcFl--aFsEI.......................	0	8	18	22
+5424	PF05596	Taeniidae_ag		Taeniidae antigen	Moxon SJ	anon	Pfam-B_8569 (release 8.0)	Family	This family consists of several antigen proteins from Taenia and Echinococcus (tapeworm) species.	20.80	20.80	21.70	25.90	19.60	18.60	hmmbuild  --amino -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.99	0.72	-4.16	11	312	2009-09-11 08:34:58	2003-04-07 12:59:11	6	1	13	0	0	302	0	60.60	39	80.77	CHANGED	--sc.sccsspslhKtluEl+c.FFpcDPLGp+lspLsK-hpphspthRpKlRpuLtEYl+sLhsE	..................csp..ppstpslhKtluEl+c.FFcpDPLGp+lspLs+-lstlspcl+tKlRtsLpcYl+sLhpE....	1	0	0	0
+5425	PF05597	Phasin		Poly(hydroxyalcanoate) granule associated protein (phasin)	Moxon SJ	anon	Pfam-B_8339 (release 8.0)	Family	Polyhydroxyalkanoates (PHAs) are storage polyesters synthesised by various bacteria as intracellular carbon and energy reserve material. PHAs are accumulated as water-insoluble inclusions within the cells. This family consists of the phasins PhaF and PhaI which act as a transcriptional regulator of PHA biosynthesis genes. PhaF has been proposed to repress expression of the phaC1 gene and the phaIF operon [1].	41.00	41.00	41.00	41.00	40.90	40.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.54	0.71	-4.39	31	264	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	196	0	80	242	32	129.00	33	71.12	CHANGED	cKpsps.......pphsspl+cpAcQIWLAGLGAauKsppEGu+lF-sLV+-Gcplc++s+phs-cplsssp.......ppht....phssslps+AsspWD....+LEphF-cRVspALsRLGlPopc-lcALpp+lDpLstplccl.sppp	...........................hpppspphhtclcchu+pIWLAGLGAa...........u+.......s....ppE.......Gu...........+.......h.......F-sLVKcGEphEccspptssc..plspsp.......pphp.......sp.hsps+spstsphs....+lEpsFDcRVspuLsRLGlPo...+p-lcsLpp+l-pLptpl-plstt.t.....................	0	19	45	65
+5426	PF05598	DUF772		Transposase domain (DUF772)	Moxon SJ, Bateman A	anon	Pfam-B_8195 (release 8.0)	Domain	This presumed domain is found at the N-terminus of many proteins found in transposons.	22.60	22.60	22.60	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.29	0.72	-4.08	160	5949	2009-01-15 18:05:59	2003-04-07 12:59:11	6	34	1706	0	1322	5334	675	71.70	25	21.55	CHANGED	GRP.shssphhl+llllphhh.sl.Sscpltctlpcshtaphh.sG......p.........tsPDtoTls..cFR.pthtppt.......hhcplhpplh	....................................GRs.uhs.t.hhl+ll....llth.hh.ul.Sscplpctlpp.slt..h..phF.st....ht..p..........thPc.hoT.ls..caR..pthtppt..........hhpplh..................................................................................	0	433	891	1052
+5427	PF05599	Deltaretro_Tax		Deltaretrovirus Tax protein	Nicot S, Moxon SJ, Studholme DJ	anon	Pfam-B_8606 (release 8.0)	Family	This family consists of Rex/Tax proteins from human and simian T-cell leukaemia viruses. The exact function of these proteins is unknown. Tax is the viral transactivator; is it a nuclear phosphoprotein that interacts with CREB, coactivator CBP/p300 and PCAF to form a multiprotein complex, which activates viral LTR and stimulates virus expression. Tax is also involved in deregulated expression of numerous cellular genes leading to T-cell leukaemia. Rex is a nucleolar post transcriptional regulator that facilitates export to the cytoplasm of viral RNA not or incompletely spliced [personal communication, Dr. S Nicot].	25.00	25.00	26.40	26.30	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-9.95	0.72	-3.68	2	33	2009-12-01 13:32:35	2003-04-07 12:59:11	6	2	8	0	0	27	0	57.10	74	73.91	CHANGED	M.hhSPLsRhhTEsshhIPSLRVWRLCopRLVs+hhhshFtPPssupPotHLstAssHLGPHRWTRhRLSSslPYPSsPLLPHPENL	......................hhIPpLRVWRLCTtRLVPHLWGTMFuPPTSSRPTGHLSRASDHLGPHRWTphRLuSTl............................	0	0	0	0
+5428	PF05600	DUF773		Protein of unknown function (DUF773)	Moxon SJ	anon	Pfam-B_8595 (release 8.0)	Family	This family contains several eukaryotic sequences which are thought to be CDK5 activator-binding proteins, however, the function of this family is unknown.	20.40	20.40	20.40	20.70	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.67	0.70	-5.72	14	218	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	140	0	135	217	5	387.50	32	91.65	CHANGED	Mp-h.sLPIDIpouKLLDWLVDRRHCshcWQppVhsIRcKIssAlpDMP.Ep-cIhpLLuGuaIsYFHChcIl-ILKsTEusTKNlFGRYSSQRMKDWQEIlphYEKDNlYLAEsAplLlRNVsYEIPuLRKQlsKspQhtpEhpR+ct-hppsAAph+ccYhpsCKphGlpGpNl+pELlsll.pDLPuhhpclutss.us.LpcAl-hYpAFssasp.......p.sstplLPlLpaltc+G.NoTlYEa+pupsPhsVEcP..chp.........phs.-......sss--p....IDW..GD......t.s....ss.u..phtstpIDaGhsh-ss.s..........-........thsGIDWG..............D..upssshpIsl.-sGos.......t...uVA+GpDAhoLLEsspsRspFlDELhELcuFLsQRLsEhp..--ssllshothphuPsllttpTscplpsMLu-VcsllspLoshphQHLFhIpuSPRYV-Rls-pLcQKh+ptchLttptpths-KppEAtpppscLcP+l-hlhppTR-LQK.IEuDISKRYssRPVNLMG	..........................................lsI.DItht+L.-WLlsR+hsshpWpt.lhtl+t+IptAht..s.......hP..pt.pt.........h.......hp.hL.......p..s............s.I....pYhc....s.h.cIl.-lLpto.-.t.s..o+.slFG.pau.up.hhc..-W....ppIl.thYEK-shaLsEhuphlhcsVsYEIPul+KQltKhp...Q..p-hp++pt-hptsttphtppahtt..Ccph..Gl.p.................G........p..s......l.+tEL.hths.ppLPs.h...t.clhtth...tp.............ltpulchYpshst.hh.....................t...ttt...h..Ls.hL..phl.pps....s.shh..p.hpt.tt.t..s....hpps..t.h..........................t...............t.tpst.......IDa..Gs...........s......t.s...t......s..tlDhu......t.t..............................t.stI.sas..............................................t...ph.sh.pts.................t...th.u.p...u...p....th...plL-.sphRsphls-LhELc.FL.......t..Rh.Eh....p...pp...........s...................s.lthp..t.t..s..l...s..........pph.thls.lpthls.lss.phppLh.lhtS.+al-plsp.Lppphpt.thhh.tht.h.t+t.ch..pp.tt.tsphphhhtpo+pLpp...........hEtplSph.aps.R.VplhG.....................................................................................................................................................................................	1	55	77	110
+5430	PF05602	CLPTM1		Cleft lip and palate transmembrane protein 1 (CLPTM1)	Moxon SJ	anon	Pfam-B_8636 (release 8.0)	Family	This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family [1]. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis [2].	19.70	19.70	20.30	19.70	19.10	19.60	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.54	0.70	-5.77	26	492	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	253	0	331	471	12	368.50	30	71.07	CHANGED	tusltuhlpslhhhhshhhhhs.Fhs......sssssssssts....t.............................htshatpsp.lsltlYsSssshhsshts.s...Llhpccshshush.sp.........shslslPcp...l.ppNGoLahHhhls.psGh.h.st....satstphh.ahsts...LspYh.p+.hp+p+NLLuspc-p...p-pcpcts.............ssphhuaa+PNlTlsllsDpsshshsslPPsltpahplpssssp........YhPllalNpFW.L+cchh.lNpTs..ppLsLplshpsluhaKaphhsph-puhppttph.........Gtsts-..h.-plKchLLDT...N.YLLulThlVolLHhlFEaLAFKNDIpFW+p+.KshhGlSlRollhNsFhQhlIFLYLhDN..cTSaMILsspGhGlllEhWKlsKslclclph...........uhlPh........ltFpD+.t.hopsEp+Tc-YDplAh+YLhhlhhPLlsuYAlYSLlY	...................................................................................................................t.......h..hhhh.h.h...hht.hh.................................................................................................shh.t.t.............h..pl...l.aho.......p.t......tt..........................hhhp...ps.h.hssh..pt.....................thphp...hspp..................h..ppN.G..ol.ah...+haht...hsG................apt..thh....hh.t..........lsp....Yh.....p...tcphsLLsspppt............p...t...ppt...............................sp.hoaa+PplolsllsDths..hshs..plPss..ltp.ahp.h.th.stp......................................YhPllahspahp....htcchh...........l......Npos........ppLs.Lplshps.................luhh+aphh.h..p...hpp.sh.........tp.h.................................................................G...s.....tp-......h.DplKthhl-T...N.YLLulThhV.......ohlH...lF-h.LAFKN............DIpFWpp+.cs.h..GlSs+olhhpsa.phllhLYlhDp..pTshhlhhs.slGhhIEh.......WKlpKshplplp.............................uhhPh.....................hth.pt................o..........EppT.............cpYDp............hAh+YL.shlhhPLhhuhAlYSLlY..............................................	2	122	178	264
+5431	PF05603	DUF775		Protein of unknown function (DUF775)	Moxon SJ	anon	Pfam-B_8676 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	20.70	20.70	20.90	24.20	20.50	19.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.46	0.71	-4.80	35	312	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	278	0	220	310	3	192.20	30	94.21	CHANGED	MFGslsuG+sspssspplss......spalhslsss...........pshsalslFl..................Lssssh.PsshuAuVYaph.P......................tsssaphLGslsssKPSAIFKlst................................hsssps..............psts.lplGISlEPhspltpphsthppspss...................................sstplAp+IlpshaNaLuSFsss..................spshVPhpshccWacKFpp+lppD..PsFL	.....................................................hFGslhsG+.s....o...shptlsp.........spalhs...lssh...........pshsHlsVFl..................L.s..s..s..sh..Psshuuu.VYhph..P..............................ssssa..phLG..hlsspKPSAIFKlst....................................ttsts............................tsssssplGISlEshpslttphsshpst.st...........................................shpphAp+llpNhaNahuSFsss..................sspthVPhpshppWap.pFppRlpps..PsFh...............................	1	73	120	179
+5432	PF05604	DUF776		Protein of unknown function (DUF776)	Moxon SJ	anon	Pfam-B_8747 (release 8.0)	Family	This family consists of several highly related mouse and human proteins of unknown function.	25.00	25.00	30.00	28.90	22.60	23.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.31	0.71	-4.06	4	60	2009-09-14 12:10:08	2003-04-07 12:59:11	6	2	38	0	33	51	0	171.40	52	62.78	CHANGED	MEutuKDGEEEoLQoAFKKLRVDAEushsshps.cu.usRsusRouh-..ssKPK.hsS.K-oWHusoRKoSRGsVRTQRRRRSKSPlLHPPKFTaCSstA.PSs.....upLKH+..o.sEPsDstuscGpus....pusssSTALssssacsahhpPhtpss.cssppossc-tAspst........sutsu.sAsc.S	...............McSEAKDGEEESLQTAFKKLRVDAuGSlASLSVG.EGsulRAsVRoAsD..-sKPKssCuSKDSWHGSoRKoSRGAVRTQRRRRSKSPVLHPPKFhHCSThA.sS.s.....uQL.KHK......opsDssD.uuouhGhss.......sus...psS.suLss.sapthsh-Phtsolschsspsppcpt.u.sss.........sSpsoLtssp........................................................	0	1	3	12
+5433	PF05605	zf-Di19	Di19;	Drought induced 19 protein (Di19), zinc-binding	Moxon SJ	anon	Pfam-B_8581 (release 8.0)	Domain	This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought [1]. This domain is a zinc-binding domain.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.33	0.72	-3.84	56	760	2012-10-03 11:22:52	2003-04-07 12:59:11	7	63	135	0	411	688	2	57.80	32	13.39	CHANGED	spFsCPaCt.c.c.aDlssLCsHl--EHsh-u+.s.slCPlC.....u.......s.......+.......Vu..p..Dhlu......Hl...ThpHu	......tasCPY..Csc.t.hc.h.s.u.LtcHlppcHp.......p......s.sp.....s...s.......s...CP..lC........u.............t.............p.......hs..s..shhp......HlshcH..........................	0	82	147	264
+5434	PF05606	DUF777		Borrelia burgdorferi protein of unknown function (DUF777)	Moxon SJ	anon	Pfam-B_8755 (release 8.0)	Family	This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).	25.00	25.00	31.70	31.60	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.03	0.71	-5.10	3	129	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	27	0	9	109	0	173.30	65	98.02	CHANGED	MocsYcIYRMNQRLYGHALAQEDlKNWIYSNIFIsRIGTVKEFKQQTQEAIVTIPEFEDLEIHTKNISNINLELSKGDsVLLLQSSINIFDKNDDIHFDKHHFYILSAISPKTLNLIsDTVKI+ANNpIEIANQoTSLKcILDsIISAINGIcIpGsusIDtoSL+......usTopINScINSLFK	.........ppDYcIYRMNQRLYGpALuQEDlKNWIYSNIFIh+IGTVKEFKpQTQEAIVTIPEFEDLEIHTKNISNISLELSKGDsVLLLQSSlNIFDKNsDIHFDKHHFYILSAISPKTLNLISDTVKI+AN...........N.pIEIANQoTSLKpI..........LcsIVSAIsGIcl.....hG....ss....s...I-.sSL+......IATopINSsINSLFK...............	0	5	5	5
+5436	PF05608	DUF778		Protein of unknown function (DUF778)	Moxon SJ	anon	Pfam-B_8777 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	22.70	22.70	24.10	23.70	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.79	0.71	-4.23	28	251	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	151	0	153	239	6	122.70	44	60.30	CHANGED	lPllSWLhPaIGHhGICsSsGl.IhDFuGsYaV................................................................u...............hDshs..FGsP.................................................s+YapL...................................................................................ctpph..s.....................sspsaDsAlppusccF.pp+saNlhs.......sNCHSaVAtsLNth........................................................pa.......psptsWshlplshhlhlpG+a	.....................................................................................................................................lPlloWhhPhIGHhG.ICsSsGV.IhDFAGsYaV................................................................S...............p.DshA.FGpP.................................................s+Yh.pL........................................................................................................................................................................c.p....ps...............................sspsWDsAlppuscca.pp+.......haNLhs............sNCHSaVAhsLNhh........................................................pY.......tssssWNhlpLshhhhltG+a..............................................................................................................................................................................................................................................................................................................................................	0	65	91	127
+5437	PF05609	LAP1C		Lamina-associated polypeptide 1C (LAP1C)	Moxon SJ	anon	Pfam-B_8782 (release 8.0)	Family	This family contains rat LAP1C proteins and several uncharacterised highly related sequences from both mice and humans. LAP1s (lamina-associated polypeptide 1s) are type 2 integral membrane proteins with a single membrane-spanning region of the inner nuclear membrane [1]. LAP1s bind to both A- and B-type lamins and have a putative role in the membrane attachment and assembly of the nuclear lamina [2].	19.70	19.70	21.60	20.20	19.40	19.10	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.51	0.70	-5.82	3	144	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	46	0	66	138	0	318.60	39	82.94	CHANGED	MKTRRoTRL.pQHSQQsslQsSPApouRGLRDApuLS+D+pEDEsSSQP-oSQTlSKKTVRSP-EAsVSEDPls+LpRPPLR.PR.-ATpVQpKssF.EEGET.EDDp-SSaSsVTpl+lRSRDScESuDKsuRAuuHas-ShWuLP+SpuDFTAH-pQPSlLoTGsQKsPQEWssQAuRhRTRMtpcsILKSEhGNQSPSTS+pQsssQPss-Sh..VK+KtWW.......LLlLVAALASGlaWFFSTPs...VETTAVQEFQNQMsQLcsKYQGQDEKLWKRGpTFLEKHLNSSpPRoQPAILLLTAARDAcEsLKCLSEQIADAYSSFRSVRAIRIDGAGKAsQDSDTVKLEVDQELSsGF+NGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASLGLKElEEKVRDFLKVKFTNSDTPNSYNHMDPDKLNGLWSRISHLVLPVQPENALKcGuCL	....................................................................................................................................................................................................................................................................................................................................t.........................................................................................t..................................................................................................................ts.........h.............h.h.hh..h..l.h..t....a..h........s............spt.s.tlpt..............F........sphppLpppa.uQst.LWpRu.hhLp+H.LpsspP.spPAhllhTAup..cuccs.L+CLupplAs.......AYo.o.........pp.sp..s...l.p.IDGss.+shtDSDhVKh.lD.cLosGFcsGppAAVV.H+FEpLPsGSTLIFYKYCDHENAAFKDVALlLTVLL.E.E.c.s.Ltsslu.pEhEE+VRDhLhsKFosSssssSascMDsDKLsGLWSRISHLVLPVts.ptlctt.C................................................................	0	16	20	30
+5438	PF05610	DUF779		Protein of unknown function (DUF779)	Moxon SJ	anon	Pfam-B_8830 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	25.00	25.00	31.00	30.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.14	0.72	-3.97	40	460	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	440	0	184	402	460	96.70	60	72.22	CHANGED	pLIccLpucHG.sLMFHQSGGCCDGSuPMCYPpGEFhlGspDVLLGcI.................sGs.....PFYlSpsQFEYW+HTpLlIDVVsGRG.uhFSLEuPcGhRFLoRSRl	...LlcpLpscHG.PlMFHQSGGCCDGSu.PMCYPpG-FhVGcsDVhLGpl...................................sGsPhalStsQ..a-hW...KHTpLlIDV...VP...GRG...G...hFSLEsPcGlRFLoRSRl..........	0	51	127	159
+5439	PF05611	DUF780		Caenorhabditis elegans protein of unknown function (DUF780)	Moxon SJ	anon	Pfam-B_8886 (release 8.0)	Family	This family consists of several short C. elegans proteins of unknown function.	25.00	25.00	29.90	29.10	21.80	17.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.61	0.72	-3.26	3	44	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	6	0	44	25	0	68.00	71	70.29	CHANGED	MADKSAYMGAGGYGSGYMGSNASSSGYAREDYAQGGNGGSsNQQQQGSGGNTNPGGQVFKARTDQSCYLGP	.....MuDKSAYMSAGGYSSGYMGSNASSSGYAREDYAoG.G.S.GG..u...s..sss.sp..GSG...Gs.sN.sGuQVFKARTDQSCYLGP............................	0	10	27	44
+5440	PF05612	DUF781		Mouse protein of unknown function (DUF781)	Moxon SJ	anon	Pfam-B_8891 (release 8.0)	Family	This family consists of uncharacterised mouse proteins of unknown function.	25.00	25.00	41.60	40.30	19.70	23.50	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.18	0.70	-5.76	6	79	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	41	0	56	78	3	311.80	39	96.99	CHANGED	MuslhohshlLlhsh.ussAhsop..ps.P..WccuPtpLSch.hpssshhlNPWVap-RMshY+ILlNuTshYhupaGs-NppNsLWGLPLQhuWQh+SGRLsDPT..t.osCG.EhsDshCISssSWWuslNYYLSlIPFLAAVcpGllususcQVpI.sPscssp+FCosYSDCssthP-sMs+WcpFFQhLhplpt..pusaucpDplLpahWsAHtpSLspuopuFsD+hsaYScsElpFppuWsphVDalAAspFsTohspohpFhpsLPPRlLpssD.psP.IsDFTspQNpsLlhlthlNcl..Npllhs.hlpLh+phhpochsR-hhpt.l..hh..P....oohlcllpchhss....ss	.........................................hlhh.h..s...ths..sts.......-hhPPLWcpsPuphuDa.lcs....sthlIsPWsY.-..Rhu.hYKIL.lspTspYFspFuspNppNlLWGLPLQaGWQacT...GRLADPo..ptTsCGh-sGDphCISlcS.WWAs.hNYaLSslPFLAAV-oGlhGhuscpVplLP.Psc...sppcFCaslosCpouaPcsMs+WssFaQ........hl.........................p.s........t..s.shD.sL....L+ahWsAHsuoLp.....suhphFp-.R..hpa...YScsEssFscsWshsV-alAAspFsTsl.pohc.FQpu.LPsRhLhssD.hsPhIsDFoshQNtVLhhLphlppl...sp..hhG....h...............................................h............................	0	9	14	23
+5441	PF05613	Herpes_U15		Human herpesvirus U15 protein	Moxon SJ	anon	Pfam-B_8900 (release 8.0)	Family	\N	25.00	25.00	210.50	210.50	19.00	17.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.55	0.72	-3.71	2	6	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	8	0	109.30	77	80.20	CHANGED	M-sW+RQRLQEhRELCPL.lLMoLSNhhSKlEhlYlKYLFpMDFsThYRaIhsuLTLohTVTKSlVIEhLFIlKRWp-IcQhFpLsl+KspDCaIVAQFsHIPlKRhlhh	MDVWKRQRLQECRELCPLPlLMSLSNIlSKlEIIYVKYLFKMDFsTMYRFILPALTLSMTVTKSVVIEMLFILKRWEEIcQFFRLNIRKVNDCalVAQFTHIPVKRhllh.	0	0	0	0
+5442	PF05614	DUF782		Circovirus protein of unknown function (DUF782)	Moxon SJ	anon	Pfam-B_8909 (release 8.0)	Family	This family consists of porcine and bovine circovirus proteins of unknown function.	25.00	25.00	231.10	231.00	19.10	16.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.55	0.72	-3.86	2	77	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	75	0	104.00	95	100.00	CHANGED	MVTIPPLVSRWFPVCGFRVCKISSPFAFsTPRWPHNDVYItLPITLLHFPAHFQKFSQPAEISDKRYRVLLCNGHQTPALpQGTHSuRQVTPLSLRSRSSTFpp	MVTIPPLVSRWFPVCGFRVCKISSPFAFTTPRWPHNDVYIuLPITLLHFPAHFQKFSQPAEISDKRYRVLLCNGHQTPALQQGTHSSRQVTPLSLRSRSSTFpQ.	0	0	0	0
+5443	PF05615	THOC7	DUF783; 	Tho complex subunit 7	Moxon SJ	anon	Pfam-B_8919 (release 8.0)	Family	The Tho complex is involved in transcription elongation and mRNA export from the nucleus.	27.70	27.70	27.80	28.80	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.63	0.71	-3.91	24	286	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	245	0	202	276	0	141.00	28	49.99	CHANGED	-plh+.pRLlh.......s--+.hpplh+phhphtp.sst...................................cssptttpplhtphsth-hshh+hphhhp.sscpEpcpYpp.pcclcpslp....sh+pp.......htpL+ppLtcA+chhcp+p....caDpLuctIssps...sRpEppc...pLp	..................................-plh+.pRLLh.......s--+.hpplhKp.hhph.ss.ss...p.................................................ccttphhpchhtphuphEhuht+t..phl.hs.hNt+EhEpYpphppcI..psplp........ts+cc...........ItchKppLppA+ph+pp+p........................EYDsLAchIsppP.....sRp-ptppl............................................................	0	64	104	157
+5444	PF05616	Neisseria_TspB		Neisseria meningitidis TspB protein	Moxon SJ	anon	Pfam-B_8925 (release 8.0)	Family	This family consists of several Neisseria meningitidis TspB virulence factor proteins.	19.90	19.90	20.40	19.90	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.62	0.70	-6.13	3	184	2009-09-11 07:48:12	2003-04-07 12:59:11	8	4	72	0	16	177	2	264.20	41	79.54	CHANGED	ah.pF...ApPl+ISDsh.s.stptu+VpKFRPcuS+Fap...........S+lTEAuslEHIPTGAKA..RINAKITASVSRAGVLSGVGKLVRQGAKFGTRAVPYVGTALLAHDVYETFKEDIQARGYQYDPETDKFVKGYEYSNCLWYEDERRINRTYGCYGVDSSIMRLMSDYSRFPEVKELMESQMERLARPYWEhlRc..NRsDSh.F+NYNFsRCYFsWNGGsCsVuKG.DDuRoFISFSLtRNPKYKEEMDAKKLEEILSLKVDANPDKYIcATGYPGYSEKVEVAPGTKVNMGPVTDRNGNPVQVVATFGRDSQGNTTVDVQVIPRPDLTPGSAEAPcAQPLPEVSPAENPANNPsPcENPGTRPNPEPDPDLNPDANPDTDGQPGTpPDSPAVPDRPNGRHRKERKEGEDGGLLCDaFP-ILACsEMGEPS-NsFEDIuIPpsTs-cTWSscNhFPSSGVCPpPKTFHVF....GRQFusSYEPLCTlAE+lRFAVLluFIIMSAFlsFGSLu+E	..................................................................................................................................................huGsGKLsR.GAKh..uTRAVPYVGTALLAaDlYpTFKEDIpspGhpYDsETDKFsK.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................Cs.....................hpat.hC.h...ht.hlhh...h...h..............................................................................................................	1	5	10	11
+5445	PF05617	Prolamin_like	DUF784;	Prolamin-like	Moxon SJ, Bateman A	anon	Pfam-B_8935 (release 8.0)	Domain	Both DUF784 and DUF1278 members are found to be expressed in the plant embryo sac and are regulated by the Myb98 transcription factor. Computational analysis has revealed that they are homologous to the plant prolamin superfamily (Protease inhibitor-seed storage-LTP family, Pfam:PF00234) [1]. In contrast to the typical prolamin members that have eight conserved Cys residues forming four pairs of disulfide bonds, both DUF784 and DUF1278 domains only contain six conserved Cys residues that may form three pairs of disulfide bonds. These two domains may have potential functions in lipid transfer or protection during plant embryo sac development and reproduction [2].  This family has been merged with the DUF1278 family.	20.60	20.00	20.70	20.10	20.30	19.50	hmmbuild  --amino -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.35	0.72	-3.85	75	362	2012-10-01 19:46:35	2003-04-07 12:59:11	6	3	20	0	247	334	0	67.40	25	51.37	CHANGED	cChs.shhp.......hpsCss-Ihtshh...uc........tplussCC.pslhphscpCast.....hh.s..phshhss............lhshCs	................................hhsshhp.......sttCsh-Ihtslh...sp........sslussCC.pslhphscsCasp.......hh.s..thPhhhs..................lhshCs................	0	90	128	152
+5446	PF05618	Zn_protease	DUF785;	Putative ATP-dependant zinc protease	Moxon SJ	anon	Pfam-B_8936 (release 8.0)	Family	Proteins in this family are annotated as being ATP-dependant zinc proteases.	21.80	21.80	22.30	22.30	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.67	0.71	-4.49	11	1019	2012-10-02 15:32:34	2003-04-07 12:59:11	6	4	489	2	289	840	428	135.10	33	62.74	CHANGED	lhG...plhL.....p.htA+hDTGAhTuSLpAsslhsap+-GppWV+F.....hhspcsppuhshEh.h.t...l+ttts............ptR.VlclhltlGsplhptEhoL.........p-RpthpaPhLlG.RuhhthhuhVDPup+alps+p	...................................................llG.hEhltlsslshs....hcA+lDTGApTSSLpA.......hc.......Ic........Fc...+.s.G..p.......p.........W.V+F......................hp.p..s.s.......p.p.s.p....h......hE..t........l...hchtc.I.+sSsuc...........sppRhVlchplp..lG.s.tph.p..hEhTL.........sDRspMsa.lLLG.RphhcsthlVDsuppalt..............................	0	70	152	236
+5447	PF05619	DUF787		Borrelia burgdorferi protein of unknown function (DUF787)	Moxon SJ	anon	Pfam-B_9013 (release 8.0)	Family	This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete). 	25.00	25.00	63.60	63.50	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.20	0.70	-5.79	2	137	2009-09-10 23:38:07	2003-04-07 12:59:11	6	2	27	0	11	119	0	334.20	72	97.88	CHANGED	MPpDTISVSLhpsRl.ssp.NYYNPLLlYKo.......sshs.hhLsLoVsNaEc.lcpLEhppGptpDp.tK...EcpL..LppAMusFF..up-uLKSsshalY.sp.cElKcaLKsphHsFVVhlNpttDs.......hpsDa-th+ps..FhVhSTK-pplhplhKsKspoEhcp.IAlYSsNc.NLHLKFhu.YLHQASIFHAVNPYGM.LsuTPlhDDolIspLRpupINFYSLLNETG.DGh.AFKEuVsLuGsSIDEhFThaYIKNEuIhELIRIWNKNsRtNSKLSALpLsGuhsNtYTuulEChh+chhpRGLIl.YKplplplsso.tLpLpLpVslpYN.ShNuVsLlITsQ-Is	....MPQDTISVSLlDSRIQAS+PNYYNPLLVYKTAKIKVNKDuAsaKhLsLTVNNYEKpIETLEK-NGNGpDQFGK...EKTL..LKTAMSsFFNSoEESLKSAsLFIYKDK..P..EELKpYLKsHRHoFVVLINTp.GDs..S..D..DGLplYKDDYsKFKtsSsFFVFSTKEQEIKELFK.DKuNoEK-RNIAVYSNN+DNLHLKFIStYLHQASIFHAVNPYGMsLuA.oPLl.DDTlIsKLRsAKINFYSLLNETGLDGlsAFKEGVDLuGsuIDEtFTYHYIKNEAIlELIRIWNKNNRQNSKLSALQLSGARDNAYTSAIECLLKRFlDRGLIlpYKsLpLTLSsTsQLKLELSVNITYNFSINuVuLVITTQDIV.......	0	6	6	6
+5448	PF05620	DUF788		Protein of unknown function (DUF788)	Moxon SJ	anon	Pfam-B_9014 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	20.70	20.70	20.70	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.14	0.71	-4.40	30	317	2009-09-15 15:32:55	2003-04-07 12:59:11	6	4	279	0	218	302	2	158.30	25	90.41	CHANGED	MAspusKKpAppNpphLptlphhhlshsslallh..hhhhspss..shhs.......hhlhshsthhshatLcphu+Ppas.........tpupLlcsG.DLpttG.h..hEYhhDllYlohhsplhshl..osKhWal.aLllPsauhYKlhs.hl..........hs.hhutssttttpt.............pspSKRQpKhE+Rtp+	..........................................................AscutKphhppNpptLphhhhhhlsssslahll...hhhhsp..ho.h.shhh.......hhhhshshhhs.hh.hhpphu+Ppas..................psGp...Lhc.....uG..DLs.htG....l.........sEahhDllhlThhsplhshh..oshhWhh.aLllPsauhY.hlas.hh......................htsh.hstsst.ttt................ttppK+pp+hc++.................................................	0	76	119	180
+5449	PF05621	TniB		Bacterial TniB protein	Moxon SJ	anon	Pfam-B_9028 (release 8.0)	Family	This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein [1] which is involved in Tn5053 mercury resistance transposition [2].	20.10	20.10	20.10	20.10	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.89	0.70	-5.66	2	273	2012-10-05 12:31:08	2003-04-07 12:59:11	6	5	203	0	59	418	28	254.90	42	95.42	CHANGED	MDEYPlIDLSHLLPAAQGLARLPADERIQRlRADRWIGYPRAVEALNRLEsLYAWPNKQRMPNLLLVGPTNNGKSMIVEKFRRsHPsuoDADQEHIPVLVVQMPSEPSVIRFYVALLAAMGAPLRPRPRLsEMEQLALALLRhVGVRMLVIDELHNVLAGNSVNRREFLNLLRFLGNELRIPLVGVGTR-AYLAIRSDDQLENRFEPMhLPsWEAN-DCCSLLASFAASLPLRRPSPIATLDMARYLLTRSEGTIGELAHLLhAAAlsAVESGEEAINHRTLSMAsYhGPSERRRQFERELM	.............................................................................................................Hl...h...ht.hss..p.-...RI..phlc.tsRWI.GYs..pA....phLsp.Lps.L.hs.h.P.p.pt.R..M...P...s....L.LlVGsoNNGKo.....h...Il.c+.F....p.+...p...H..........s..........s........s....s....D....s....c...t....c.....t....h.............PVlhlp.h....P..spP.s.....h....+h...Y.sul.L...s...tht...............A..P...h.......+.s.....p.........s....p.....l.....s.c...h..c..p.s..l...t..L...lR....c.h....s.l+M..LlIDEl.Hs..l.L.u.G.ss..h..p.....p..R.....p.h....L...N....h...L+.aL..uN..E...L...p..IP..l....V....u..V..G....T..............c..............-A...h....h.......A....l....p....o.D.......s.....QLt...s...R......F.....-......s......h.....h......L..P...h...........W.....c.....h....s.....c........-.....h.....p.....p...L.....L...sSF.t..ts.L....P...L..+.+..s.S.s.l.s..s....h...-.h.AphlhshSp.GslG-ls+LLhsAAlhAlcoGcEtIstchlp.......................h...................................................................................................................	0	9	29	48
+5450	PF05622	HOOK		HOOK protein	Moxon SJ	anon	Pfam-B_8981 (release 8.0)	Family	This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes [1], whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head [2].	35.00	35.00	35.00	35.10	34.70	34.70	hmmbuild  -o /dev/null HMM SEED	713	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.52	0.70	-13.24	0.70	-6.72	9	557	2009-09-11 15:29:52	2003-04-07 12:59:11	7	9	169	1	312	507	1	523.20	26	58.15	CHANGED	Ms...c.KhELC-SLlpWLQTFpluAPCpslp-LosGVAhAQsLpQIDPuaFsEuWLs+IKpD.VGcNWRLKsSNLKKILpulh-YYp-lLupplS-thlPDltpIuEpSDssELGRLLQLILGCAVNC-cKQ-aIQpIMsLEESVQ+sVMsAIQELho+cpssosus-shssh-pQL++hh.-LpEs.p-+-ELAQRCpEL-hQlhhL.EEKsuLhpENphLp-chsph-..........oh.sPsplsu++a.pLQpQLEQLQEEsaRLEuA+DDhRl+Cp-LEK-lhELQpRN-ELToLApEspuLKDElDlLRpuuDKsspLEupl-oY+KKLEDLsDLR+QVKhLEE+NshYhcpTlpLEEEL+KAsusRuQlEsYKRQVQ-LHsKLspESp+A-KhtFEh+pLcEKh-ALpKEKERLltERDoLRETs-ELRCuQhQtspLs.ts...ussu.ot-sLAAElhPsEhREpllRLQ+ENKhL+htQEGu.pp+.stLQphL--ANppppcLcoppRLsppRIhpLptQlE-LQKtLppQGu+s-s..sspLKpKL-tHhcpLpEsp-Elp+KpthlE-LpPctsps.spKIsELpsALppKDp-h+AME-RYK+YlEKA+pVIKTLDPK.p....AssEl.hL+p..........QLsE+DtclptLEp-h.cts+.hR-.EEpLIloAWYNhGhshQ+cAh-uRLsshus.........sGQSFLApQRpsTssRRshssp..s....souK	...............................................................l.h.Wl.po.....h........t..............t.................t...p.....h....pLssGhhhtplh.pI.sst..hs.......p.....p.l.p.p.p...sssshpl...+...h...pNLphllptlhpY.......hp-h..Lt.p......l.............lPs...l...........hIu.....c......p....s....s.........t.......E......l...t..................+L.L..Ll...LGCA.V........pC.ppKp.........caIppI.t.L....-.ssQt...........sl....hst...I.Q...E.....lh.p...........p......p....p.......s.....s.......p.........s....t......t....s.......t.p........h...-......t..t..........................p........p......h....h.....p.......l......p...c..h..ht....c..p..-.p.h..........t...p.......p.....h...t....-...h...p..p..l.....L.p.p...E.+s....s.L...............t..p.....p........h..t...p.p.h..s..p..p................................................................p.t..s.p.p.h.h.u.h...c....hh...p....h..p.t.p....lcpLpp....E..........c....h.....p...t..t.......h.Dh....+h.....ch.....p...ph..........-....t..c.....l..tclp...p.c.sp.p...............Lhs.....A....c.p...spth+DElD.LRppup+....ss+LEsplpph+.c.+Lp-..hp.h+tpl..ctLcEpN.t...hhhpp...p.h.L......E-pL....c.......t.s.p.......s.......t....p.s...p...l.....c.......p.......hc.+.......p...h.............p.Lptc.h.pp.ptp.ctp.....p..h...h-hp...p....lp.......cchp.....t....l.....cp.....p....t...p....l..........p.h...t....p....h.......p......p.......h......c.pL...c.hs.................t....t.....t.tt..............................st.s.p...s......h......s.t.El...............................t..h..p..p....p..hh....+.........L......p....hE......N.....p....L................t.........p.....t..............................................t..............h.t..........p....lc.pt...p...........t...h.t.....p.lc...pp............p............p.p........p.......h.....l......p.t.p...h....tp...p...p...t.....t.....p..tt..........pt...........p...t.p.h...pt.......th....p........ph.........t....p.t............................h..pp.....................................................................................................................................................................................................................................................................................................................................................................t...............................................................................................................................................................................	0	90	122	209
+5451	PF05623	DUF789		Protein of unknown function (DUF789)	Moxon SJ	anon	Pfam-B_9113 (release 8.0)	Family	This family consists of several plant proteins of unknown function.	20.60	20.60	23.40	21.40	18.60	20.40	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.98	0.70	-4.94	19	248	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	38	0	149	236	2	246.60	32	51.85	CHANGED	oNLERFLcusTPsVPsphhsp...sshps.psh.....pppphsaFtLsDLW-sFcEaSAYGhGVPl.......pLssu.-sVhQYYVPYLSAIQl.....ass.pphhs...................................Rp.s-su-st......S-u.Scsp...................thtpt.psushspst.....tsphGplhFpYhEpssPasR.PLs-KlspLupcaP...........tLpoL+SsDLuPuSWhSVAW......YPIY+IPss.slcDLsuCFLTYHoL..uoshpss.sp......................................t.spclsLPsFGLAoYKhpGslW..................ss..pts...p-....ppphtoLhpuADsWL+pl........pV.pHsDapFF	.............................sl-pFltsso.P.l.......hsp........tthpt.pth...............t.pt..hF.LsDlW-tacEhSuY..Gh..u..Vsl.........hLsss...c..plh..QYYVPaLSAIQl.asp..tt..............................................pt..pps.ptt...t..t..sps.st.t..............................................ptt.p.pt.........pt.s..hFpYhEpp..Pa...tR.PLh-K.........lppLupphs.............tLhohcosDL.PsSWhuVAW......YPIY+IP.s....s.pcl.s.ssFLTaHsL..usshptt.........................................................................................t..tphsLsshGltoY+hp..u.phW.............................s...t..p.......pphh.tsL.psAssaL+th.......................ps..pH.DapaF.............................................................	1	25	93	119
+5452	PF05624	LSR	LISCH7; 	Lipolysis stimulated receptor (LSR)	Moxon SJ, Mistry J	anon	Pfam-B_9152 (release 8.0)	Domain	The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids [1].  It is thought to be involved in the clearance of triglyceride-rich lipoproteins, and has been shown in mice to be critical for liver and embryonic development [2].	25.00	25.00	30.60	30.00	22.50	22.10	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.42	0.72	-4.23	3	176	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	39	0	70	137	0	48.90	70	8.91	CHANGED	cWLTVLlIllGALLLlLLlGICWCQCCPHsCCCYVRCPCCPsTCCCPE+	....-WLhVllVlLGuhLlhLLlGI.C.WCQCCPHoCCCYVRCPCCP-pCCCPc.....	0	3	9	27
+5453	PF05625	PAXNEB		PAXNEB protein	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_9269 (release 8.0)	Family	PAXNEB or PAX6 neighbour is found in several eukaryotic organisms.  PAXNED is an RNA polymerase II Elongator protein subunit [2].  It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme.  The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity [2]. This protein family has a P-loop motif. However its sequence has degraded in many members of the family.	20.50	20.50	20.50	20.70	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.14	0.70	-5.62	30	316	2012-10-05 12:31:08	2003-04-07 12:59:11	6	5	262	3	225	365	7	338.60	25	89.19	CHANGED	oSFp++tht......................p..p......hP.....GlRPS.spsupsoTSTGsssLDplLuGH.GLPlGohLLIEEsuoT-auulLL+YFuAEGlVp..............spclaVsu.h...sppaspcLPGhhpsssppcccs.......................sppps-cMKIAWRYpplschpsussssp........................sasHpFDLTK+L.sps.hsslsalshsss.........................................................................................s.....asullpplpshIppp.........sssslhRlsIPSLLsPshYsspsupsp.......llsFLHuLRuLlRt.ss.psssllTlPhsLas+....ssuLsphlcpLsDuVIcLpPFstp.........cttsss....tK..pGLl+lpKLPsLs-+u.shhscps....DaAFKLuR+K.FpIEpauLPP--s-ppsppsst.....................sstsscpsLDF	....................................................................................................................hs.GhRsS.s.hs.u.p...hsSTGhssLD.plL...uG............GLslG.s..lL...............l.E...E..........st.............hs.s......authLh.+hFhApGllp..............spplhlhu.h...........stthhpp...L.......Pu.h..tssptpp...p.p.s...............................................................s.pp..ppphKIAWRYpth.sphpss.sssp................................................tasH.taDlo+ph...p.h.....tsph.hhh....t................................................................................................................................................htpllpplpp.hlppt.................ttpplhRlsl.u.LhuPhh...h..s.s.p.....t..sp.t......................lhpFLasLRuLlR..........s.........s.h.....s..........sshlTl.PhpLh...........sssl......hthlpplsDsllpLpsFstp.................pttts.....hct.p...Gll+lc+lPhh...sshs...shhspst.........................-h.uF+lpR++.FhIc.hplP.s..sptttptttt.........................................................................................................................................................	0	83	128	187
+5454	PF05626	DUF790		Protein of unknown function (DUF790)	Moxon SJ	anon	Pfam-B_9309 (release 8.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	20.20	20.20	20.60	20.60	19.60	19.90	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.14	0.70	-5.94	13	146	2012-10-11 20:44:44	2003-04-07 12:59:11	6	3	123	0	80	152	24	374.90	31	88.07	CHANGED	MLPpELLcs+.tpcGcIhPpaus....-cl-LAcpVIphF+pplGcphG-LpcclcplE.ptpNYKhVRGhA+lL.....cRp.spF-ssoslDPhclRchLFct....G.ssocpERpclLpc..........sAcch......sso.p-lE+ulaADhEEE+lLsch..............................PsIoP--Ll+pYNLSLlQTLlFcAhclsl....plsss...aKcllRtIKtLGLMYpl.s.............................................t.t.hplclsGPASLh+hoc+YGsulAKLlPtllpscpWpl+A-ll......pscRlYpFcLsSppshhh.chppt......................................................aDSslEcpFspchptlh.uhclhREP-llplGppsaIPDFhlp+.ssp+VYVEIVGFWT.EYL++KlEKl+csshshLlllscE.L....t.tphchsspcVIhF++.KIshscVhthL+	......................................................MLsp-Llph+..hpstplhPhahs.....pphpl...ApclIphFpttlGps..pu-LpcplppLp..p.................t.............Da....+lhRGLu+lL.................ccp.spFE.h.hu.sl-PtclRpplFpt..........sss..h.......p.......p.....p......R..ptsLpp..........lAppL......tl...pclpcuhYADLc-pphLsp.h...............................s..s...sP-pLlcpYNLuLsQsllacAsclpl.....pst..ss....aKtlh+h....lKhhtL..Mahlpt.............................................tsp.shplpl-GPsSLh.ctop+YGhphA+hlPsll.pssc.....WplpAplt............p....ts.p.+shphpLss.p.s.shh.s..c..h.s.s..s..p....................................................aD.StlE.psFupca..pp....h.....t.....p..sWpl.REs-hlsls....s..p.VhIPDFt.l..........p..................+..s.......sp.......chhlEIlGFWssEYLc+Khppl.cps.p.t...s...Lll.sssE..L....ussph..pt....hs..t.pllhF+p.plp.psVhphl................................................	0	18	52	69
+5455	PF05627	AvrRpt-cleavage	NOI; 	Cleavage site for pathogenic type III effector avirulence factor Avr	Moxon SJ, Coggill P	anon	Pfam-B_9342 (release 8.0)	Domain	This domain is conserved in small families of otherwise unrelated proteins in both mono-cots and di-cots, suggesting that it has a conserved, plant-specific function. It is found both in the plant RIN4 (resistance R membrane-bound host-target protein) where it appears to contribute to the binding of the protein to both RCS (AvrRpt2 auto-cleavage site) and AvrB, the virulence factor from the infecting bacterium [1]. The cleavage site for the AvrRpt2 avirulence protein would appear to be the sequence motifs VPQFGDW and LPKFGEW, both of which are highly conserved within the domain [3].	20.30	20.30	20.80	20.30	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-7.88	0.72	-4.91	22	371	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	42	2	166	352	0	36.90	43	27.04	CHANGED	spcpspslPKFG-WDsss.PASA-GFTVIFsKsR--Kcos	......t...ptssVPKFG-W.D.sss...susupsaTslFsKsR-cKps.s...	1	22	94	132
+5456	PF05628	Borrelia_P13		Borrelia membrane protein P13	Moxon SJ	anon	Pfam-B_8766 (release 8.0)	Family	This family consists of P13 proteins from Borrelia species. P13 is a 13kDa integral membrane protein which is post-translationally processed at both ends and modified by an unknown mechanism [1].	25.00	25.00	27.00	27.00	19.50	23.20	hmmbuild  --amino -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.79	0.71	-4.36	5	121	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	37	0	9	87	0	126.40	51	78.98	CHANGED	TsLpYESpKsslL.APFLLNLFLoFGIGSFVQGDYIGGGAlLGoQVLGGILllTGhIlss....ssssssp.huIoGtlLhGIGsLTIAuSYITSIIIPFTFANRYNANL+K+LGIuLAGFEPNFDIGIN.....G...FQLSFKKSY	.............hhhY-opKpssl.sPFLLNLFLsFGIGSFsQGDhlGGuhlLGF.....shlGhhL.hhsGhh..L.sh..............s.spcs...hhhGthlh...hhGssThsso+lsplIlPFTFANpYNcpLKppLslsLuGFEPsFDluhs.....G.....FpLSFKKSY.......................	0	5	7	7
+5457	PF05629	Nanovirus_C8		Nanovirus component 8 (C8) protein	Moxon SJ	anon	Pfam-B_9354 (release 8.0)	Family	This family consists of a group of 17.4 kDa nanovirus proteins which are highly related to the faba bean necrotic yellows virus component 8 protein whose function is unknown [1].	25.00	25.00	151.80	151.70	17.50	17.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.07	0.71	-4.42	3	31	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	9	0	0	30	0	151.80	70	100.00	CHANGED	MADWFcSsLKTCTHVCDFscIuuDS...QQ-lhCCDSM+GKLp-PRKVLLVSCpVSFNGSFYGuNRNVRGQLQlSMp-DDGVsRPIGYVPIGGYLYHNDYGYYEGc+TFNLDIESDYLKPDEDasR+FpVSIlN-NGLD-pCDLKCYVVHSlRIKV	M..DWAESQaKTCTHGCDWKsISSDSu-NRQYVPCVDSGsGR.KoPRKVLLRSIEssFNGS..FpGNNRNVRGFLYVSIRDDDGtMRPVLlVPFGGYGYHNDaYYFEGcupspCDI.uSDYlsPs.DWSRDMEVSISNSNNCN-.CDLKCYVVCSLRIKE	0	0	0	0
+5458	PF05630	NPP1		Necrosis inducing protein (NPP1)	Moxon SJ	anon	Pfam-B_9369 (release 8.0)	Family	This family consists of several NPP1 like necrosis inducing proteins from oomycetes, fungi and bacteria. Infiltration of NPP1 into leaves of Arabidopsis thaliana plants result in transcript accumulation of pathogenesis-related (PR) genes, production of ROS and ethylene, callose apposition, and HR-like cell death [1]. 	21.00	21.00	21.10	21.10	20.30	20.90	hmmbuild  --amino -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.56	0.70	-4.60	27	493	2009-01-15 18:05:59	2003-04-07 12:59:11	6	12	160	3	323	429	0	179.10	32	74.56	CHANGED	sssshthcapPhlch.scGChPhPAlsssGssuGGLps........o.Guh................................suuC+-put..suQsYuRusp..N..G..hhAlMYuaYF.KDpshs..shGuHRHDWEaVVVWlss....ss.plhtVosSuHGsappt.s.sssph-Gs+sKlsYapshss.sHshchsssss-..........p.sLlsW.....sshss.ssRctL.......pssDFGsA.......slPh..KDusFtspLspA	...........................................................................s..phhhpapP.Lch..s.sGChsaPAVss.sG.s..s...uu.G..Lps.........o...Gs..s.............................................s.usCpsss....uQ.......l........Y..sRush..s....s......hhA..IM.YuWYFPKDp.s.....ss...............s..h....G.HRHDWEpl.l.V.Wlss......................ss..pl...h.u.l..u...sS...s.H.u..s....app.............t............s..........s............h.....s....G.....s..psp.ltYhtsh.h......sHthphsss..s........G.....p.....................htsLlhW..............-thss....suRsu.L.......p.s.s.s.FG.p.A........p.h.Ph..pDs.sF.tpLtt..................................................................	0	86	163	303
+5459	PF05631	DUF791		Protein of unknown function (DUF791)	Moxon SJ	anon	Pfam-B_9328 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.28	0.70	-5.76	3	263	2012-10-03 03:33:39	2003-04-07 12:59:11	9	6	145	0	180	646	62	301.10	33	72.54	CHANGED	FYYLVFGGLAAVVAuLELuKouKDRlNToPuFNSFKNNYLLVYSlMMAGDWLQGPYVYYLYSoYGFuKGDIGpLFIAGFGSSMLFGTIVGSLADKQGRKRAClTYCIlYILSCITKHSPpYKVLMIGRlLGGIATSLLFSAFESWLIAEHNK.............................RGF-sQWLSlTFSKAlFLGNGLVAIISGLFANLLADsFGFGPVAPFDAAACFLAIGMAIILuTWSENYGDsSDsKDLlsQFKVAApAIASD.plhhLGtlQSLFEGSMYTFVFLWTPALS..PNDEEIPHGFIFATFMLASMLGSSlAuRLLuR+.LRVEuYMQIVFLlSAsoLhLPIVTshLVsPSpVKs-GLSLsuulQLLGF	......................................................................................................................................t....sF.pF..p.pal...hVY..L..h..h......su...D....W....LQ....GP...Y.l.Y....h.....L.Y.p.p..Y.u..hsct....p.....I.u.h.L...a...l..s.Ga..u.S..uh.l.h.....G.s.h..s.....G.....s.....L.....u.Dp.h.G.R+p.u....C.l.h..a..s.l.h.Y.........l..s....C.....l......o..............K..h.s.s..p.a..h.....l.L.h.....l.GRl.L..G.Gl....u.T.....o..LL..F....S...s.F.E......u...Wh..l..t..E...H.t.c...................................................................................+..s.a...s....t..p...h..L..sh..T.F.u.pu.s.......hh.N.ul..l..Alh.uG.l..hup....hl.s..s.........h.........h..u....h............t.............lu.PF..sA..h.shL...s...l.u..hs.l....lh.tsW....s..E....N...a.G..s.............................t......p...p..........s.....h...........................t..p.h.....t...t........u...h........p....s............l...h...s........D............p+....l....hhLGh.h..Qu.lFEu.uh..Yh..F..VFLWTPs..Ls.............spt....t...........t....l....P....h...Gh....lFus.FMhupM....lGSslh...hhhs........p.p....hp..s...t..hh..hshhh..sshsh.h......................................................................................................................................................................................................................................................................................................	1	75	112	149
+5460	PF05632	DUF792		Borrelia burgdorferi protein of unknown function (DUF792)	Moxon SJ	anon	Pfam-B_9387 (release 8.0)	Family	This family consists of several hypothetical proteins from the Lyme disease spirochete Borrelia burgdorferi.	25.00	25.00	36.90	36.70	23.10	22.30	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.46	0.70	-4.99	2	136	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	28	0	10	109	0	194.90	67	97.49	CHANGED	hsIKNKN..NsNhEpKK.tEh.p-.......EIhpII+DlhTQlFsLFGADNFLlLFPR.Dh+GFGYVPQLFFIKPKTpLIoRTYNTSCSKRPsINYYDRKAEYVSYNsVMTGEpISLsGGILTShYKDMLSlhKhTVFGNhhhRFDuHLsKEQLANRlQAQVPFoIYSPTFGLKELAlITsLoFKDhPFIDEVEVSLShElVKTFcLEKYKG	........................................pph.tp...p.......EIo+II+DVlTQIFALFGADNFLVLFPRhDLKGFGYVPQLFFIKPKsELIoRTYNTSCSKRPV.INYYDRKAEYVSYNPVMTGEpISLNGGILTSLY.K-.MLSlLKMTVFGNohLRFDuHLsKEQLANRlQAQVPFSIYSPTFGLKELAlITSLoFKDTPFIDEVEVSLSlEIVKTFs..LEKYKG......	0	6	6	6
+5461	PF05633	DUF793		Protein of unknown function (DUF793)	Moxon SJ	anon	Pfam-B_9395 (release 8.0)	Family	This family consists of several plant proteins of unknown function.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.40	0.70	-5.71	7	188	2012-10-01 23:20:42	2003-04-07 12:59:11	6	6	24	0	111	233	0	230.20	22	80.18	CHANGED	hPAT-aQu........hhShLSlRRsQhss......ssspppE.p....EL-sFQ++VAE+FhDL........usSs.........tslLSlpWltKLLDsFLsCppEF+uIlhstts..QISKsP.hDRLls-hh-RulKALDlCNAlhsGl-plRQap+hhEIsloALcpp........PLG-GplRRAK+ALhsLsIuh.s-....Ksuuuusss..ppNRShsRshs.........ht+RohG............ph+S.oWuVSRsWSAuKQlQAhsuNLssPRus-ssu...Ls.PVYhMoSVhlhVMWsLVAAlPCQ-R.GLtsHhs.sP+phpWAuslhSla-+Ih-E.K++-+Kp.usGLhcEhpphE+hu+.L.EhsDuhcFPhs--c.p.EVtpcVpEhhplCcthcsGL-PhpRpVREVFHRlVRSRoEhL-sL	................................................................................................................................................................................................h..hsh.ah..hh..h....ttht.hh...........h........-chh..hh-.sh+hLDlh.sht.tlt.l..pt..phhh.hsht.h....................................................................................................................................................................................shh.ht..hhhh.h.hhs.hh....s......................t......au.sh..l.p.l.t-.t...........tt............................h.htEht.hc.....h............hht............t................................................................t.....h...h........................................................................................................................................................	0	21	78	93
+5462	PF05634	APO_RNA-bind	DUF794;	APO RNA-binding	Moxon SJ, Eberhardt R, Barkan A	anon	Pfam-B_9606 (release 8.0)	Family	This domain contains conserved cysteine and histidine residues [1]. It resembles zinc fingers, and binds to zinc [2]. This domain functions as an RNA-binding domain [2].	25.00	25.00	33.30	25.70	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.32	0.70	-5.13	7	186	2009-01-15 18:05:59	2003-04-07 12:59:11	6	9	21	0	116	189	0	158.30	36	77.96	CHANGED	Ls......ptht.ts.spppp.psp.sDlP.....+.c+KPaPhPhKclpcRAKEchp.tp.t.p+.L..PPcNGhlV.pLVPVAcpVhpARphLlpsLspLl+..VVPVpsC+aCsEVHVGshGH.h+oCcG.ssstRpu.HpWssGslpDVllPlEuYHLaDphs+.RIpH-pRFshPRlPAllELCIQAGV-lP-aPs+RRppPlh.htt.cllD	...........................................tht.............................................................................thh.lApcshpA.aptlhpGlp+Lhc...hhsVpsCtaCsEVHVGshGHph+....h....Ctuh.cpptRsGpHsWppusl-DllsPh.saHlhD.h..Gt.......lp..c-.hRh.Ys+hPAVV....ELClQAGspl.P.c..............................................	0	10	68	94
+5463	PF05635	23S_rRNA_IVP	Ribosomal_S23p;	23S rRNA-intervening sequence protein	Moxon SJ, Eberhardt R	anon	Pfam-B_9648 (release 8.0)	Family	This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes [1-3]. It folds into an anti-parallel four-helix bundle and forms homopentamers [4].	23.30	23.30	23.40	23.30	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.20	0.72	-4.15	122	1034	2009-09-11 08:57:14	2003-04-07 12:59:11	6	5	486	10	434	1051	267	104.30	26	82.27	CHANGED	psac...-LclWp+uhcLshplYc.lopshP.p.cpauLpsQlcRuulSIsoNIAEGhuRp..osp-ahcFLtIApGSssElcopLhluhclsalsp.pph......ptlhpphpclp+hlsuh	.................................hppl.happuhphshplap.hs.p...ph..s.p...p....c...p..a...s.L.ss.QlpRu..........usSlsuNIAE.Gh..s...+p..opp-ahphLpIA.......tuShtE.hph.L..ls.hc.hs...a..l.s.p..p.ph......pt.lhpphpplhphl.t.h..................................................................	0	178	349	412
+5464	PF05636	HIGH_NTase1	DUF795;	HIGH Nucleotidyl Transferase	Moxon SJ, Anantharaman V	anon	Pfam-B_9692 (release 8.0)	Family	This family consists of HIGH Nucleotidyl Transferases	19.90	19.90	19.90	19.90	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.40	0.70	-5.43	10	1483	2012-10-02 18:00:56	2003-04-07 12:59:11	6	2	1444	1	204	1046	11	364.90	35	97.14	CHANGED	McssGIIsEYNPFHNGHhYHLppucc.spssltIAVMSGsFlQRGEPAIlsKWpRucMALpsGsDLVlELPssaSsQuA-aFApGAVcILspLu.l-sLsFGSEpsslccapclAclhs-+ttchcphl+p.L.scGhSYPpuppcsac.....phtG.c.thp...htoPNNILGlpYsKAlhptspsIpshoIKRpuAsYHDt-l...ccphASATuIRptl.......................tpclctlc+hVPssohcll....p.hsshsshscaFshLKYpllt.osccLcsIapVsEGl-sRlh+ulppupsac-hlcLlKTKRYThoRlpRlLTalLlNhcp.........psstssaI+lLGFocKGQpaLpphKKshs.....lPlIT+luptshct.....hph-l+AopIYpLs.....ppshspp-Fs+sPI	...........................................MphsGlIsEYNPFHNGHtYtlppu+p...t.s...s...l....h.I.s.lMSG..NF..lQ..RGEPAIlsKWsRAcMALpsG.sDLVlELPhhhulQuA-hFApGAV.plLstLu...l-.s...lsF.......G.o.E...ps.plps...hpplAchhp..cp....t...t..ph.p.ph.lcp.h.p.p.u.hSYPpthp.t.hh.p.........................p.h.h.t......p...hphs............tsPNsILGlpYhKAl...t.....h..s..p..s..IphhsIpRpu.....usaHst....ph...............ctp......hAS....ATuIRptl..........................................................p..p......s..t....l.cp.h....lP...psshthh........................s.....s...h...h..s......h..c...pa.......as..h....L........+.Y...pl...l..........t...otp..c......LpsIap..l..sE...Gl....-sRl.........pps....l....p..p.......u....p......o......hcc.....hlctl.KTKRYThsRlpRllhalLlshp...t...........................tppt.sp.hl+lLGhsc+Gp.paL+....plKpp.........lsl....l...o..+l.sp...p.......s.h..ph........................hthph+As..p..lYph........st.....ppsasp.s.............................................................	2	79	138	173
+5465	PF05637	Glyco_transf_34		galactosyl transferase GMA12/MNN10 family	Wood V	anon	Pfam-B_6000 (release 8.0)	Family	This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of C. elegans homologues where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.	20.40	20.40	20.50	20.40	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.58	0.70	-4.86	14	639	2012-10-03 05:28:31	2003-04-07 12:59:11	7	9	211	4	419	634	57	209.70	22	55.28	CHANGED	pssclVllhuSs.pss.....s..tp.hltpslcN+l-YAc+H..........GYshhahpssshhh...thsss....WuKhPhl+psMpcaPcAEWIWWlDpDAllhshphsl.chhh..phLpphhhpp...........sshpph.cpshs.cupshhhlhspDasGlNuGSFLlRNspauthllDhWs..............-Phhtppsts...pcEQsALsallttHsplhsphuhls.................+hlNuYp.ut.t...............................hs.c-GDhllHFsGCpstssCt	..............................................................................s....hlhlhh.p.t.h............h..p.hpN+hcYschH...................Gaph.h.h.....tshhp.........tphtt................Wt.Kls..hlRphh...h......taP..c...sc......ahaalDt-shhhs.shp.........................................s.pth.p...h................p..s.....s..lh......p...p....shtu...l..NsGsFllR..s........spWu....h...hL.-.h.Wh...........................h.hh......t.h.......tt-.QsAl.....hl....h...t.............p................h....htp..hs.hl..............................................tchh.p.t...a..t.................................................ht..pch.s.hlsphsGCp.t...............................................................................................................................	0	104	243	356
+5466	PF05638	DUF796		Protein of unknown function (DUF796)	Moxon SJ	anon	Pfam-B_9698 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	21.80	21.80	21.80	21.80	21.30	21.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.75	0.71	-4.15	152	2770	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	1013	13	450	1429	75	135.10	28	72.81	CHANGED	alpl.s...G.....Is.........G.pstpp..s.HccpIplhuasasls.shs.......sutssGpsshpslphsKhlD+uSPhLhpuhss.Gcplppsplphh+.....ssG............p.t.cYhplpLps.shlsslsssss.............tt.hshEslslsYspIphpap	............................................Ylpl.s..G.......Is..............G..pshtp....s..Hcsp..I.lhuapasls....s..........su.....tsuGps...shpshphsKhlD+uo.PhLhpuh....ss......Gcpltp.....splph.hR......sssG.............p....cYhphpLps.shlsslshphs......................ttphp.hEplslsYpcIphpa.h.........................	0	69	183	306
+5467	PF05639	Pup	DUF797;	Pup-like protein	Moxon SJ, Bateman A	anon	Pfam-B_9797 (release 8.0)	Family	This family consists of several short bacterial proteins formely known as (DUF797).  It was recently shown that Mycobacterium tuberculosis contains a small protein, Pup (Rv2111c), that is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl carrier protein (FabD) [2]. Pupylation of FabD was shown to result in its recruitment to the mycobacterial proteasome and subsequent degradation analogous to eukaryotic ubiquitin-conjugated proteins. Searches recovered Pup orthologs in all major actinobacteria lineages including the basal bifidobacteria and also sporadically in certain other bacterial lineages. [1] The Pup proteins were all between 50-90 residues in length and a multiple alignment shows that they all contain a conserved motif with a G [EQ] signature at the C-terminus. Thus, all of them are suitable for conjugation via the terminal glutamate or the deamidated glutamine (as shown in the case of the Mycobacterium Pup [1]). The conserved globular core of Pup is predicted to form a bihelical unit with the extreme C-terminal 6-7 residues forming a tail in the extended conformation. Thus, Pup is structurally unrelated to the ubiquitin fold and has convergently evolved the function of protein modifier.	20.10	20.10	20.10	20.10	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.44	0.72	-3.48	15	351	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	337	8	108	262	19	65.20	44	96.99	CHANGED	Mus+csGGGQpcsscptpt.t.....ssssussptRpcclo-DVDDLLDEID-VLEpNAEEFVRuYVQKGGp	............................ttt...........ttpt.p.......ptt....stssssuppppc..ch.s.--l.DDLLDEIDsVLEpNAE-FVRuaVQKGGQ..	1	32	78	100
+5468	PF05640	NKAIN	DUF798; 	Na,K-Atpase Interacting protein	Moxon SJ	anon	Pfam-B_9801 (release 8.0)	Family	NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localise to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterised domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer [1].	20.00	20.00	21.20	21.30	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.50	0.71	-5.36	13	270	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	79	0	133	229	0	164.50	53	73.51	CHANGED	MGsCSG..RCoLlhlCsLQLlsALERQVFDFLGYQWAPILuNFlHIllVILGLFGTlQYRsRYllsYslWssLWVsWNlFIICFYLEV.GpLS+.............................DoDL.LTFNlShHRSWWhEpGPGClsp.ls..sushshcs++hloVsGCLLDYpYIEVlHSuLQIlLALhGFlaACYVsplhh-EEDSFDFhsu..................PhYho....s	.......................................................ls.sLERQlFDFLGY...QWAPILuNFlH.IlhV...ILGlFGTlQYRsRYlhsYs.lWhsl.....WVsWNlFIICFYL.EV.GsLS+.............................DoDl...hTFNhShHRSWWhEpGPGChhp.s...ss...................hs.cspphloVsGClL-apYlElhHSu...lQIlLA.LhGFlaACYVsphhhEE..EDoh..ch.............................h........................................	0	21	34	71
+5469	PF05641	Agenet		Agenet domain	Bateman A	anon	Pfam-B_2551 (release 8.0)	Domain	This domain is related to the TUDOR domain Pfam:PF00567 [1]. The function of the agenet domain is unknown. This family currently only matches one of the two Agenet domains in the FMR proteins [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.17	0.72	-3.82	34	609	2012-10-02 16:56:36	2003-04-07 12:59:11	7	25	73	4	302	580	6	67.00	32	12.42	CHANGED	hppGstVEVpSccpsh..csuWatAhllpt.sct.....chpVcapshphpstts..............hp-plshpp.....l....RPsPP...	..................tcGscVEV..h..S.cs.ssh...suWahApVhhhpuc..............hahlcYsshs.ss..........................hsEhVshcc...................l..R.PssPs..t...............................................	0	52	141	206
+5470	PF05642	Sporozoite_P67		Sporozoite P67 surface antigen	Moxon SJ	anon	Pfam-B_8657 (release 8.0)	Family	This family consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. The antigen has been shown to contain five distinct linear peptide sequences recognised by sporozoite-neutralising murine monoclonal antibodies [1].	26.10	26.10	27.70	27.30	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	727	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-13.24	0.70	-6.67	3	31	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	10	0	10	32	0	320.00	20	85.01	CHANGED	MpIlHFLLTIPVIFVSGGDKMPAGESPRTSKPSPLVTLESAlTQPSKDP...FKTVuALSKATKVWKSAVSlSDDSKTVPTPVSEPhITRSFQEP..................VSQESElQs-TEhNpuscGS+oDSE-DDD...............................................-pEEEDNKSTSSKsGKGSpKu.QPGVSoSSGSTTSsTssoTslSQTGLG..uSGSH....AQQDPuVu.sGV.........VGVPGLGVPGVGVPGsG...GsGshPGVGVstsGVuPGVGVG...........................G.GGV..........................PGVGl......................................tSsoSpEG--sDDpEc-t-s+shp.......................................................................PGVGlPGVtV...........GsoTSSoSTToPSoSTTTTTPoSSG.PSs.Gu.GoSsRNAVTRpTDSISGPIPSPG-PRAITGQM..........GEcEpFAVQFLGDFKPKPRRYEGscT-ssKLKKFIFEEVKSLVpTLINLKLAIANDFVEITEKLKKpNQNHVPKLKLLKGsQFDTKQKVANVLKGFNSLYFVlFMNLNLAKEVN+PEELAEhLWKLNTIPDKVu+EFELAlEKTKuSEKKsELEEAFKSIslGFKIAYYATNDILSSITNSVYsLIKLKNFGDDFVTEVRKSLQMVPHQKNLNGSSFIVKISEhMNKKGTEsQDQTSGuGS..............KGTEGGSLRG.DLTEEEVLKVLDELVKDVSEEcVGIGDLSDPSSRSPscKPAcLGPSLVIpNVPSDPoKVTPTQPSNLPQVPTo.....G.GNGT-Gs-QsPuusNG......................oGNGEGGKDLKEGEKKEGLFQKIKNKlLGSGFEVASlIIPMTTIIFSIVH	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ss.......................	0	1	5	5
+5471	PF05643	DUF799		Putative bacterial lipoprotein (DUF799)	Moxon SJ	anon	Pfam-B_9829 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function. Some of the family members are described as putative lipoproteins.	20.20	20.20	21.60	20.30	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.47	0.70	-5.02	3	303	2012-10-01 20:48:06	2003-04-07 12:59:11	6	5	289	0	76	216	14	207.60	45	91.96	CHANGED	MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSHNGILKGPRFVEEQPK	.......................................................................................h.hh........h.....hs.s..sl..h..L..ouC.s....st.....s...p.h..D.Y.o..uF..KpSKP+S.ILVLPPlNcSsDVpAoauhLo.psTh.P.LA.E..uGYYVhPVA.lV-ETFK.QNGLTsAuDI..puls.PsKL+cIFGADAsLYloVspYGTsYpllsSsTpVoAsA+LVDLRoGchLWs..G..S..A...o.s..p...-........s.u..s..s..u...s....u....G.....L.lGhLVs....AsVpQIsso...loD.cuapluuhsuspLLSs..sp.s...G.lLhGPR........usth...........................................................	0	15	39	58
+5472	PF05644	Miff	DUF800;	Mitochondrial and peroxisomal fission factor Mff	Moxon SJ, Eberhardt R	anon	Pfam-B_9868 (release 8.0)	Family	This protein has a role in mitochondrial and peroxisomal fission [1].	21.10	21.10	21.80	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.72	0.70	-4.74	9	222	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	83	0	105	189	1	189.30	36	94.98	CHANGED	huE.scl..EhcYTcsISppMRVPc+lKssush.--p.hhspsss..........cph.MpVPERIVVhGpspch.shStPR-lpL.pSs....P..uhlplpTPPRVlTLo-+.hs.h-.Estssssss...........spE.+shsph+Rtpusucsu.hppsupls+sD..............uhh...................s......u....p.........................shsshssslEshosc.tls...sLRRQIlKLNRRL.hlEtENcpRtpREhlhYulslAaaLlpoahWLpR	...................................................................................................h..p.tasptIsppMRlPcpl+sss.....t.....p.......t........hpp.t...............tph...MpVP-RIllh.Gpstc................hs...P.t.-ltl.puh........P...t.ltlpsPPpllTLscp....hs.h.p.pt.....t..................p..h..s.phhc.ts....s........tptt...ptt.......................................................................................................................................................................ths...hts.hp...shs.c.plh....LRRQlhKLNRRl.hLE.pstpRtpREhlhYslsluahllpsahWhpR.....................................................	0	24	33	63
+5473	PF05645	RNA_pol_Rpc82		RNA polymerase III subunit RPC82	Moxon SJ	anon	Pfam-B_9884 (release 8.0)	Family	This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa [1].	21.90	21.90	22.30	22.00	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.51	0.70	-4.85	29	304	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	256	2	191	294	1	231.10	19	43.22	CHANGED	sthhcLhpppal.plsp....s.....t.h.tpthpph..ssshsphcpps-sc.phptphtshhppsp.sh........t...t.ht..suh+t.......................hcssls..hphNh-+FphphRsptLlphs........................cs+lGpsouplYcthL+hhcppssshpts.............................shshosp-lt+tl.spshslpts............................................................................................................phlspaLpLLusss.htFlpchus...GpahVsapclhppL	.........................................................................................................h.pLhtttal.ps.......................t....h...tt........s.....t.ph....hpt.....p..h...h.....htt..htphhpt..sph.t..............pt.tt..hs.t.sput+ptt.........................................pts.h..-sslh..hplNa-+FthphRsptllshs..........................ps+hspsouplh...cshLchs..chpssp.ht.........................................ohshohspIhcpL...tphs..lsts............................................................................................................................................................................................lppaLplLspss....hhtc.....t.......s.ahl.hpphh..............................................................................................................	0	53	97	151
+5475	PF05647	Epiglycanin_TR	DUF801;	Tandem-repeating region of mucin, epiglycanin-like	Moxon SJ, Coggill P	anon	Pfam-B_1480 (release 8.0) Pfam-B_13922 (release 26.0)	Repeat	The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus [1]. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells [2]. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21 [3]. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).	27.00	14.00	27.00	14.00	26.70	13.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-9.97	0.72	-4.17	6	290	2009-09-10 21:16:35	2003-04-07 12:59:11	6	13	12	0	150	263	0	55.90	52	110.76	CHANGED	sossuoSTsSuuASTssNsuSS.sTSuuTSTsosouS.SsTSSGoSTAsNsASosTTuuSuTtssTGTpTTo	......tstuST.sSs.usSTuTNopSS..sTS.SGsSTsTNScS.STTSSGuST....ATNStSSsTs.......................	0	114	114	114
+5476	PF05648	PEX11		Peroxisomal biogenesis factor 11 (PEX11)	Moxon SJ	anon	Pfam-B_2629 (release 8.0)	Family	This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.	23.80	23.80	23.80	23.80	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.33	0.70	-5.08	61	883	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	300	0	540	829	5	206.20	18	85.16	CHANGED	lsphlcalsposGRDKlhRslQYsu+hluhhh.pp...s..stphsshhcpl.....csphohsRKhhRhh+slstlpsutthh..sp.t......Dsll+hhsllppluhuhYhshDplsWlsphGlhpspstp....+hsphusthWhhuLlhullpslhplhthppphpphtt........................psscsspptp.................phtpcphshhhsllpshsDlhlslstL...uhl...phssshlGlsGhlSSllGlhsha	...........................................................................h..hhtp...ut-+hh............+h.hpah.sphh..h....................................t.t.............tt.httl.........................ptp...huh...sRp..............h...hRhh....p.........l....phhp...thh..th...........tp......................s..h..hphh...t.......h..h...p...p..hs.shYh...h...h....-pls....a.......l..s.....p..h....Gl.....hs......hpttt...................phtp...........h.ush....h....W.h.hullhulht....p..hhplhth.tpptp.phtt.......................................t........p.........................................................thhppp.h.hhhsllp..shsDhhhslstl......thh........ths.sshlGhhGhhSulhuhhp.......................................................................	0	168	289	432
+5477	PF05649	Peptidase_M13_N		Peptidase family M13	Studholme DJ	anon	Swiss-Prot	Family	M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure  regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk. 	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.46	0.70	-5.42	156	3507	2009-01-15 18:05:59	2003-04-07 12:59:11	8	35	1646	10	1445	3238	341	342.10	22	54.54	CHANGED	s-DFYpassGsWlcpssIPs.cpsph..............us.FspLpc...pspppl+.............................pllcph...tt.t.............................................................................................................ssstp+htshYpushD.hssh...........cptGhpPlpshlpp.lsu.h................p............spts........................................................................ltphluph....hts..............shhsh.h.....VssDh..cs...s...sp....hlhlsp.......su.luL..PccsYYhppp..................................tphhpsYp.paltclhph......h......G..............................ht.s.............pspptAp...plhshEp.pLA............phphsp......tcpcc.pph................Ys.hsh.......s-Lpph.....h..ss......ls.............a.pphlpshhh.............................st........p...pllltp.....................ss...ahptlspllps...sshp.....slpsYlhaphlpshush..Lspshpptphpa.t......................sltGhtp..ts......+hcp.slsh.ss...st..lGpslGp............hYVcc..hFssc.u....Kpphpphlpslppuapppl...p.shsW.......Mssp....TKppAh.pK..............Lsshp.cI.GYP	...................................................................................................................................pcDFapass.G..t.....W..hpp..t..lPs......spsph......................................us..Ftt.L.t.c...p..pp..hlp.....................................phlpp........................................................................................................................................................................................ss..pph.t....phYpts.....hc...pth.........................cth.G......h....p...P..l..h.......t.hlpp...lt..s.....h..........................................sh.s....................................................................................h.phl.s..p.ht..htht.s...................hhsh.h......lssD.....ps...s.......pt.........hlh.hst................su..lhL........PspsYYhp.pp.........................................tphhptah..phhtphhth......h.............u..........................................................h.t.p......................psp.p...hp...p.llphEp...plA.......................phhhsp.........tcp...p..-..t..th.................................Yp.hs.h.......s-.hpph............hst...........................................hs...............h.ttahpthh..............................p.s.....p.......plll.p..........................p.....ah....p....t...h..s..p..ll...sp.............p.s..hp..................hhps.a..hh.h.p.hl.p........thssh.....Ls.p.php..p.h.pht.a.t...............................sl..Gh.p......s............ph+t......shph.sp...........s....h...s.slGt........................................hYspp.....hF....s...p...u..................K...t....p.........h.pp....h.l.pplhp.......sa.pppl............p...p........s.W.......h..st.p..T+p..pAh.tK..............lst..ht.tl.GYP..................................................................................................	0	507	719	1169
+5478	PF05650	DUF802		Domain of unknown function (DUF802)	Yeats C	anon	Yeats C	Family	This region is found as two or more repeats in a small number of hypothetical proteins.	22.60	22.60	23.10	24.10	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.57	0.72	-3.85	40	307	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	124	0	97	342	6	53.40	35	15.48	CHANGED	losph-sosuslAs.......sWspALApQppuspuLsppLcsuLsphApsF-p+uuuLl	........losth-sosuslus.......sWpsALApQppuscsLupphpsuLsphusoF-p+SAuLl...........	0	13	31	67
+5479	PF05651	Diacid_rec		Putative sugar diacid recognition	Yeats C	anon	Yeats C	Family	This region is found in several proteins characterised as carbohydrate diacid regulators (e.g. Swiss:P36047). An HTH DNA-binding motif is found at the C-terminus of these proteins suggesting that this region includes the sugar recognition region.	21.40	21.40	21.40	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.50	0.71	-4.75	54	1274	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1153	0	179	746	9	132.30	47	35.86	CHANGED	LsppLAppIVpRsMplIsaNlNVMsppGlIIuSGDspRlGphHEGAlhulspp+slpIspsssppLp.GV+.PGlNLPlhapscllGVlGITG-P-plptauELV+hsAELllEQuthhcphpWcpRtpEchlhpLl	..................LcsphAQcIVsRsMcIIs.p..N.INVMD.tcGhIIuSGDpcR.IGph.HEGAlLsLs.ps.....+.s.V-.I.-c.s.s.AppL+....G.V+.tGINLPLp.h.c.scllGVIGlTGE.P.-plRpYGELVpMsA.EhhlEQspLhc..lt.-pRh+EEhlhpLl.............................	0	51	97	134
+5480	PF05652	DcpS		Scavenger mRNA decapping enzyme (DcpS) N-terminal	Moxon SJ	anon	Pfam-B_9894 (release 8.0)	Family	This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the N-terminal domain of these proteins. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway.	25.00	25.00	28.80	27.30	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.49	0.72	-3.68	20	268	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	220	18	181	258	0	107.40	33	32.37	CHANGED	pphlscFchp+lLspsspsKsIsLLGpls.......s..csAIlllEKTsFph...-pl............................huhhss.................hpplcpltpNDIYtWhlshhtpcls............slKlsLIaPATppHI+KYspQ	...............................................t..lspFchp+lLsp...........ssp..sKpls.LLGp.ls...............s..csAllllEKssFth.....-ps.........................................hshhsu......................htclp..lhsNDIYthahshssp....p...hs..............................slKlslIaPAT-pHIcKYppQ...............	0	52	88	144
+5481	PF05653	Mg_trans_NIPA	DUF803;	Magnesium transporter NIPA	Moxon SJ, Eberhardt R	anon	Pfam-B_9876 (release 8.0)	Family	NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters [1,2].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.95	0.70	-5.46	7	1396	2012-10-02 19:55:49	2003-04-07 12:59:11	9	14	342	0	935	1629	226	236.20	25	61.05	CHANGED	hp.D.hhGlhLAlSSSlFIGuSFIlKKKGLh+hut.uuhRAupGGauYLpEhlWWuGhloMhlGEsANFAAYAFAPAsLVTPLGALSlllSAlluphhLpE+LphhGhlGChLsIlGSsllVlHAPpEppltSlpplhphhs-PuFllashhllssslhLlhhhtP+hGpppllVYIslCSlhGuLoVhSVKAlGIAIK.ohs.Gts.ltashsWlhlllhlhClshQlNYLN+ALDhFNsulVoPlYYVhFTT.slhsShIhFK-Wts.shsslhspLsGFhTllsGsFLLHsh+Dhs.sp	..............................................................................h.......Gh.lsh..u......shh...u..uh.....l..p......+...h..............u..h.h...p..t............t..............................t......s........h.....s.Y...h.....pp.h.....W..W.....h.G.h...h.........h..................h..........h.l.G..p....h.ss....F...s....AY....uF.......A....P.........s.lV..................sP..L..G.u.lu.l.....l...h..........s......slluthhL.p...E..plp........h..hs........h.......l........G.........s.h..lslh.G.s.s.l.l.....l....h...h.....u......s......p.p...p...t..h...........s...hp......ph.......t.h.h.h...p...........................s.....F.l..ha.h.h....h..........h........hh......h......h...h..........h...........hh......h......h...........t.................................t...................s.......t.........p...........p........h............h.....l........h..l.....ls.....u......h...................h.G..u....h....o....lh...ss....K.u.....lu.hhl.t.....h.t.....s............h..............h..a.h..h...h...h..hh.h..h..s.h..................hh..Qh..alNcuL...p.......hass..sh.......l.Ph...halhaT.....sl...hs.....u....hlhapt.a.t...s....p............hh..h..hhG..hhhh.h.Glhll.p.........t..........................................................................................................................................................	0	287	502	740
+5483	PF05655	AvrD	Pseudomon_AvrD; 	Pseudomonas avirulence D protein (AvrD)	Moxon SJ	anon	Pfam-B_9946 (release 8.0)	Family	This family consists of several avirulence D (AvrD) proteins primarily found in Pseudomonas syringae [1,2].	25.00	25.00	59.70	33.70	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.06	0.70	-5.55	3	71	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	50	0	13	69	0	260.20	35	96.63	CHANGED	MQDLSFSoIENHLGPAKDRFFGDGFKHVEYSARHVNLTESA..VcAoIoLSYPANWSKKNcSuELlPHLSSIDALTISlNLSQDILLNcFKSID.....HCWVRRISIKAGsKPEEDLR-INA..KITKESQGLDSpGDThLIFGGNVGTMTVQLEFIIPAAHEI-TlKDS..............oEKSCYSLHFKNRTQFIDDIIFYSPLN.AIS+LFVAaDsE.PNFLPGGIEANYPNIlNPVDSLVSHAQIAQALLYKLDGLTR-ESNTLWMRsLNIIAENPAKRpAATRLLVTELKRANIVSlKGcNWRVAEVAGHMNGIThSSSVAHLLPL	.................................tsl-phLGstcpRaFGpGa+psphphpph....thstpt.....hpu.ho....l..sYPu.sWScKsss.-lhPHLSoIDAlhlusplup....tllh...p..ph....p.u.l-.......psa.l++loI+AGpcP....E.DLp..s..l..s..A..plsppt.s.ps..ss..t..hhFt.spl.usMplplph..hh...s.....t...cph.....t.shpss..............sp.cphao.ta+s.......+pphlpclhh..ss.hs..shu.p.lhh...t.stt.sph....Ghpu.s.a.s...shhs.lDsLlshAQluQsLlY+LDslsRspSsTLWMRplsl..h..spp.....Ph...t..ht..t.t..lhs....ph.csphl.phtsppWR...sph...s..........s..t...hphpsplAH.L.........................................	0	1	8	13
+5484	PF05656	DUF805		Protein of unknown function (DUF805)	Moxon SJ	anon	Pfam-B_2800 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	26.80	26.80	26.90	26.80	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.91	0.71	-4.28	159	3368	2009-01-15 18:05:59	2003-04-07 12:59:11	9	20	1884	0	465	1828	801	123.10	28	77.08	CHANGED	pahsFpGRusRp-aW.hhhLh.hllhhh......hh.hlshhh........................................thhshlhhlhhl...shhl.......Ps....lA...lsl..RRLHDhs.+SGW...................ahLl.................................................hhl...........P.hlGh............................................lh...hll....hh.h................h.u...p.s......sNp.aGssPts	......................................................................hhsFpGRspRp-.a........W..hhhL.h...h.l.h.h.h.l....lh..hlthhh......................................................hhh.sll...s.h.l.a.s.l....h...shl..........Ps...........hA.......lslRRLHDps..+SGa...................Whll.........................................................................................................hhl....P..hlsh..........................................................lh....llh....hh.s................hs.u...sss..tN+.aG.ss..h............................................................	0	122	259	367
+5485	PF05657	DUF806		Protein of unknown function (DUF806)	Moxon SJ	anon	Pfam-B_7291 (release 8.0)	Family	This family consists of several Siphovirus and Lactococcus proteins of unknown function. The viral sequences are thought to be tail component proteins.	25.00	25.00	26.30	26.10	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.51	0.71	-4.09	9	73	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	68	0	13	71	1	122.90	31	97.19	CHANGED	hpPsppsppllpshshshlDpVYhssIPcEhlsNsspThVLlTEstssPspauNssFpuhshGVElQIFYphsls.pDhp..ssEIpLh+thpcscWplssS+sHhhDPDTs....QhpKshYhs+sh.I	...........................hPl.pltpllpshshshlD..plahsslPpEhh..cssspThlLl..TEssss.stauNssFpshshsVElQIFYppshs.pDhp.......phElpLh+hhpsscWhlss.u.+sHshDPDTp....Qlppshahs+sh...........	0	4	7	10
+5486	PF05658	YadA_head	Hep_Hag;	Head domain of trimeric autotransporter adhesin	Yeats C	anon	Yeats C	Repeat	This seven residue repeat makes up the majority sequence of a family of bacterial haemagglutinins and invasins. The representative alignment contains four repeats.	20.20	20.20	20.30	20.20	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.39	0.73	-7.61	0.73	-3.49	239	9521	2012-09-20 11:56:39	2003-04-07 12:59:11	9	620	916	22	1068	8054	662	27.80	37	11.89	CHANGED	AsGpsusAlGssupA..sussosAlGssup	.............AsGpsSlAlGssutA...sussSlAlGsso................	0	242	496	794
+5487	PF05659	RPW8		Arabidopsis broad-spectrum mildew resistance protein RPW8	Moxon SJ	anon	Pfam-B_7373 (release 8.0)	Family	This family consists of several broad-spectrum mildew resistance proteins from Arabidopsis thaliana. Plant disease resistance (R) genes control the recognition of specific pathogens and activate subsequent defence responses. The Arabidopsis thaliana locus Resistance To Powdery Mildew 8 (RPW8) contains two naturally polymorphic, dominant R genes, RPW8.1 and RPW8.2, which individually control resistance to a broad range of powdery mildew pathogens. They induce localised, salicylic acid-dependent defences similar to those induced by R genes that control specific resistance. Apparently, broad-spectrum resistance mediated by RPW8 uses the same mechanisms as specific resistance [1,2].	24.00	24.00	24.10	25.10	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.75	0.71	-4.66	10	146	2009-09-21 12:32:58	2003-04-07 12:59:11	6	17	20	0	59	159	0	131.50	27	27.49	CHANGED	PluElhs.........GAALGluLQlLa-Alp+AKD+ShTT+sILcRLcATIpcIoPllscIDKlScch--s..R+VlEcLK+LLEcAssLVEsYAELR.RRNllKKaRYpR+IKELEuuL+WhlDVDlQVsQWsDIKELhAKMSEMsTK.....LDcItsQP	.....................................clhs.........GusLGhsht.Lh....cslhcspc+uhph+shlc+LpsTlcsIpPhlhc.Icphs..pchsps...pc.hccLpphLccuhpLlcphsclp.phshh.++hp.Y...tp+lcpl-tplthhhpsplplp.htDlpclhsthtt.............................................................	0	11	45	49
+5488	PF05660	DUF807		Coxiella burnetii protein of unknown function (DUF807)	Moxon SJ	anon	Pfam-B_7114 (release 8.0)	Family	This family consists of several proteins of unknown function from Coxiella burnetii (the causative agent of a zoonotic disease called Q fever).	25.00	25.00	112.70	111.80	21.70	16.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.61	0.71	-4.52	4	23	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	2	11	0	138.40	57	59.30	CHANGED	MLtApLhF.GphslGPI.PcSYFGNsGAI.sPcIc.KlATGcYTIThLSuRslppTQPulVHIslhD-sNtsFCsRlsKulpFTYcPpNo-.FPWKhhhpIAlpEt-hhtIcpKp....l.VTh+hhpcupGslVssGhhptcshhNV	.......MLtApLhF.GphslGPI.PcSYFGNsGAI.sPcIp.KhATGcYTIThLouRslppTQPssVHIsh.D-sNtsFCsRlsKslpFTYcPpNSp.FPWKhhhpIAlpcGDGohhDsp.....VMlThthtNpsstAlhssshsRspAclNs	0	2	2	2
+5489	PF05661	DUF808		Protein of unknown function (DUF808)	Moxon SJ	anon	Pfam-B_7112 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	25.00	25.00	35.80	26.10	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.88	0.70	-5.59	47	1348	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1301	0	257	880	93	282.80	53	95.12	CHANGED	MAGuSLLsLLDDIAolLDDVAlMTKlAAK..................KTAGVLGDDLALNAQQVoG..VpA-RELPVVWAVAKGShhNKhILVPAALLISAalPW.........lITPLLMlGGhaLCFEGhEKlhHKahHp..........p.cppptpuhscss........hDLsAaEK-KIKGAIRTDFILSAEIIsIsLGoVustshhsQlhVLusIAllMTlGVYGLVAGIVKLDDhGLaL.p+sus.....htctlGtuLLssAPhLMKsLoVlGThAMFLVGGGILsHGlPslHHh...lc.hstth.......ussluslsPsllNullGllAGulllhll	...........hAhuSLLsLLDDI.......Aol.......L.......DDlulMuKlAAK..............KTAGVLGDDLALNAQQVoG..VpAsRELPVVWuVAKGSLlNK.l.I.L.V.PhALlISAFhPW.........hITPLLMlGGua.....LCFEGsEKllHhh.s+....cc...........pp...p...pph.t.ss.............tDshthEKcKlKGAIRTDFILSAEIlsIoL.GhV..u...p.........s..s....lhsQllVLusIAlllTlGVYGLVulIVKlDDlGhaLs...c...+uus........................hhpulG+GLlhhAPhLMKsLSlVGTlAMFLVGGGIl...V........H.G.....l........s.....s........L........H.....H.h.............lEchst.t..t................uuhluhll.ssllshllGhlhGulllh........................................	0	55	142	209
+5490	PF05662	YadA_stalk	HIM;	Coiled stalk of trimeric autotransporter adhesin	Yeats C	anon	Yeats C	Motif	This short motif is found in invasins and haemagglutinins, normally associated with (Pfam:PF05658).	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.52	0.73	-6.66	0.73	-3.98	75	6882	2009-01-15 18:05:59	2003-04-07 12:59:11	9	631	823	15	787	5827	118	22.40	61	6.44	CHANGED	ppIoNVAsG...ssuTDAVNsuQL	...ppITNVAuG....ssuTDAVNsuQL..	0	128	332	567
+5491	PF05663	DUF809		Protein of unknown function (DUF809)	Moxon SJ	anon	Pfam-B_7264 (release 8.0)	Family	This family consists of several proteins of unknown function Raphanus sativus (Radish) and Brassica napus (Rape).	25.00	25.00	107.20	104.70	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.18	0.71	-4.25	4	16	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	11	0	131.20	97	99.95	CHANGED	MITFFEKLSTFCHNLTPTECKVSVISFFLLAFLLMAHIWLSWFSNNQHCLRTMRHLEKLKIPYEFQYGWLGVKITIKSNVPNDEVTKKVSPIIKGEIEGKEEKKEGKGEIEGKEEKKEGKGEIEGKEEKKEVENGPRK	...MITFFEKLSTFCHNLTPTECKVSVISFFLLAFLLMAHIWLSWFSNNQHCLRTMRHLEKLKIPYEFQYGWLGVKITIKSNVPNDEVTKKVSPIIKGEIEGKEEKKEGKGEIEGKEEKKEGKGEIEGKEEKKEVENGPRK....	0	0	0	0
+5492	PF05664	DUF810		Protein of unknown function (DUF810)	Moxon SJ	anon	Pfam-B_5709 (release 8.0)	Family	This family consists of several plant proteins of unknown function.	19.20	19.20	19.40	19.30	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	677	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-13.12	0.70	-6.25	10	230	2009-01-15 18:05:59	2003-04-07 12:59:11	6	14	75	0	160	222	1	430.80	22	48.43	CHANGED	uLocsDLRETAYEIllAustuS.....tshhh...pthtppc..................................S+sKhhLuL+tpt....................................ttssupst+sc+shohsElMRhQMcloEphDsRlR+sLL+hssuplG+RhEsllLPLELLpplps.o-FsD..cEYcpWQ+RpL+lLEtGLlh+PslshscosppspcLRpll+s.....uhspslsouppoEsh+oLRpsshSLutR.upsGh...su-sCHWADGYP..LNl+LYptLLpusFD.hD-ssll-El-EllELlK+TWssLGIs.cslHslCaAWsLFpQaVhTu..E.tLLtsAhstLt-VutDtp.ssp-slYlK................hLsSsLSulhuWu-K+LhDYHcoF......scssl......sh-slVoluhssu+lLuEDsspth+cptt.........ss+-+l-pYIRSSl+sAFsc...........cuphtts+uspssttsLA.LAc-ss-LAhpEpphFSPlLppWHP.usGVuAupLHpsYGscL+paLuuhscLT.DsVpVl.uAscLEpsLVphh...usss.-DGGculh+.ch.PaElEshhusLVhsWlpt+l-clpphV-RshppEsWcPtSs.cpsaAsSAVElhRllcETl-tFFtL.IPh+sshLpsLscGlDpuhQpYsspshuuhGu+pshlPslPsLTRhpcsotlhshhKKchhssstscc+tspth..............shslspLCVRLNTLcalhocLcsLE+	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................................................................h............Pa..........ph....-phhhsh...lhpWlptp.pph..phlppshpp.....-.....p.......a.....p...sh........s.............t........p........p.taus.Ssl-lh+hhpp..............sl-th.h.tl........h...s.......c.......t...h...h....sLhpuls.....thht......Yhphh.....t.th....s...s....c..p..p.hh.P..h.s..LoR.ppt...h.....hh.+ct..............p................................................hh.p.hl+lNslpahhpplp.l-.................................................................................................................	0	27	89	125
+5494	PF05666	Fels1		Fels-1 Prophage Protein-like	Yeats C	anon	Yeats C	Family	\N	25.00	25.00	47.40	26.90	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.27	0.72	-4.59	12	669	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	339	0	28	193	6	49.60	50	79.54	CHANGED	sAhA..spssslhoPusGVlCDph..lCtD..........StGlShslTccYhGp+	.............u.ts.ssu..o.AsGVhCDsh..lChs..........S.stIs.phT+hhhhp+....................	0	4	10	19
+5495	PF05667	DUF812		Protein of unknown function (DUF812)	Moxon SJ	anon	Pfam-B_7417 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	30.00	30.00	31.60	31.20	29.40	27.80	hmmbuild  -o /dev/null HMM SEED	594	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.71	0.70	-6.01	10	190	2009-09-10 22:47:38	2003-04-07 12:59:11	6	4	106	0	126	188	1	373.50	26	88.19	CHANGED	M..-ElDpIIlHoLRQlGs-lsE-lpuLcsF..........ToshlVcsVs+CLplIsPsl..sLP+oLP.s.....uMApRFpluopLApACp-lG..YRu-IGYQTFLYsNss-lRpllMFLlEpLPR-p.suscus...pPlu.............psstLccpIspsLppQLp...............hPWlPphsR.............h...s..shptFpsp.hsl..sspsp.tt.ssthpphapp.hl.slo......tslssolLpsssuplshsschch-a.utsh......E-hcpcKppplpp+ltshhppstt....s......suucpls-llpp.t.t.........s..hspppt..........spphuss.usssssshssEcstpppcps-L-uLpppIcclpsplpphpsch+phpuplpplp-phpstcppssclEpphKlKc+TstLLsDsEsNl....sKLpullsuoup+hhpLssQWEs+RsPLl-phcpL+thpppp.scoppphccIcslRpcIcclspElpsKsphappL.spaEshs+s.VsRouYTcRILEIIuNI+KQKp-IsKILsDTRsLQKEINsloupL-RTFsVTD-LlF+-AK..+DEtsK+AYKhLAsLHssCs-LlcsV--TGslpREIRDLEcQI-sEct+s	......................................................................................................................................................t.....h.........p....l.th..........sst.hhphh.thl..lp........t........ths......h.P.........shst+hphs.tluphh....p..G..h...phua......p............p..hLYss...p.....h+tl..hhhLhppL.stt...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ht..h......h.t..t.ht..t.h......t.h..p...t.t.t...........p....tt.ht.h.tph..h.h.ps.t.....h......pLp.hhtttttph.plttpWp...thch....h.tphpthp...........ttp..h....tplp.hctphpth..chtt+pp.hppL.t.........phpphspt..h......s.......R..YhpRIhEhhtsl+KQct-I.+lh.-s+.lQpphs.httplpRpashs--hlappu+........p-...........h+.....psY+.Lstlct.httlhthl..hs.h.pphh....chp.pl...........................................................................................	0	48	64	98
+5497	PF05669	Med31	SOH1; 	SOH1	Moxon SJ	anon	Pfam-B_7443 (release 8.0)	Family	The family consists of Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant [1] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes [2]. 	25.00	25.00	25.00	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.63	0.72	-4.29	34	308	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	274	4	217	302	0	103.10	44	60.92	CHANGED	sshsRFplELEFVQsLANPpYlpaLA...pp.........pYa..................p-.pFlsYL+YL.pYW+cPcYu+alhYP.pCLahLc.lLpsppFRpslsssss....hphl....pphhhpattht.pthph	.......t.phRFplELEFVQsLANPpYL.s.............aLA...Qp...................tah.................................c-psFlsYL+YL.pYW+..cP-Yu+aLpYP.tCLahL-.LL.Qp.-.pF...Rptlsssps......hch.l..tppthhtW.tht.....t.........................................	0	73	119	181
+5498	PF05670	DUF814		Domain of unknown function (DUF814)	Bateman A	anon	Pfam-B_738 (Release 8.0)	Domain	This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity [1].  Hence the activity of this C-terminal domain is unknown. This domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.88	0.72	-4.10	39	2812	2009-09-13 15:36:20	2003-04-07 12:59:11	8	19	2349	0	939	2335	311	89.80	31	16.57	CHANGED	ahhoss.ahllsG+ssppN-hL.sh+hhcppDlahHscthsuuHVll+spstps.p........slp-AAphAstaS+.h+tuspssssY...........sphcalpK	............h...sssshhIhVG+NshQN-.L..sh...K..h..Acp..s.D...l..W.......h....Hs+.cl.PGSH.Vl..l+s..s..t..s.s.s.p.............................slp-A....ApLAuh..aS...........c...ucpu......sp.lsVca...............sth+pl+K...............................................	0	362	602	811
+5499	PF05671	GETHR		GETHR pentapeptide repeat (5 copies)	Bateman A	anon	Pfam-B_8059 (release 8.0)	Repeat	This pentapeptide repeat is found mainly in C. elegans.  The most conserved amino acid at each position leads to its name GETHR (Bateman A unpublished obs.). The family also includes a divergent repeat in a microneme protein Swiss:Q26588.  The function of this repeat is unknown.	21.50	21.50	21.90	21.70	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.12	0.72	-4.80	3	9	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	3	0	9	25	4	23.90	70	46.64	CHANGED	GETHRGETHRGETRRGETHRGET+R	....shRGET+RGET+RGET+RGET+p.	0	6	6	9
+5500	PF05672	MAP7	E-MAP-115; 	MAP7 (E-MAP-115) family	Bateman A	anon	Pfam-B_8157 (release 8.0)	Family	The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin [1]. The binding of this microtubule associated protein is nucleotide independent [2].	28.50	28.50	29.00	29.00	28.10	28.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.28	0.71	-11.64	0.71	-4.87	3	338	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	64	0	136	296	0	159.00	47	22.95	CHANGED	APuussNuuAsuKPoAGTTDsEEATRLLAEKRRQAREQRE+EEQERREQEEpDRpcREELtpRsAEER.sRREEEARRpEEEcAREKEEp..............hpRpAEEc....thpEQEEQER..lQKQKEEAEARuREEAERhRLEREKHFQQpEQERLERKKRLEEIMKRTRKSEVS-phKKpDsKs	................................................sssssK.ssAGTTDsEEAs+lLAE.KRR.AREQ+E+..E...EpE.R.......h...c...pE.....Ep.-.........R......t....t.....+.......E.E..t......p+.h...tE..E...............R.t+......pE.-E.uR+.h.E.-....c.......pt.R.c..c.tcp................................t.t..tcEc...........tppEp...EE..pE+..........lp+QKEEAEu+..u+EEAE+.RhEREchhppp.EQE....RhERKK....RlEEIMKRTR+...o-s...stp.pt.............................................................................	0	13	29	65
+5501	PF05673	DUF815		Protein of unknown function (DUF815)	Moxon SJ	anon	Pfam-B_6403 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.51	0.70	-5.45	75	1159	2012-10-05 12:31:08	2003-04-07 12:59:11	8	7	1089	0	330	2454	848	243.70	43	76.12	CHANGED	spshAapWc......s..uh.Lpsl.............ppscslpLspLhGl-cQ+ctLlcNTcpFlpGhPANNlLLaGuRGTGKSSLVKAllspasspG..........LRLIEls+-DLtsLPpllshl+....spP.p+FIlFsDDLSFEps-ssY......KsLKulL-GulpupPsNVllYATSNRRHLlPEhhsDsts........ssElHss-ulEEKlSLSDRFGLhLuFashsQ-pYLplVcpas.............pph....ulshst...........cpLcpcAlpWuhp+GuRSGRsAhQFhpclsGch	.....................................................................................s.shAFhWp.........stpsh..LpPl.............tp..ss.t.lpLscLhGl-p.Q+.c....t......L.......h...c.......N...T.......c.........p.....F.....l..p...G.........h.........P.........A...........N..N.........s..L.L.aGuRGTGK.SSLlKA.ll.spats.pG.........................L...R..L.....l...E.....l....p..+.....c..D...L.........t...s.....L....s....c.......l..l....s....h....l...+...................p.p....s........+....F.....I.l.F...CD.......D....L.............S.......F..........Ec...s.-.s...sY...............K....s.....LK..u....l...L....-..G...u..l.p.s........p.P.s....N...VllY..AT.SN.RR.HLlsEphp-Nps.........ssElHsu-u.lEEKl.S..LSDR...FGLWLuFashsQccYLphVctah...........................pch......slshsp..............-pl+tcAl.pWuhpRGuRSGRsAhQFhpphtGp.h.............................................................................................	1	102	225	279
+5502	PF05674	DUF816		Baculovirus protein of unknown function (DUF816)	Bateman A	anon	Pfam-B_7178 (release 8.0)	Family	This family includes proteins that are about 200 amino acids in length.  The proteins are all from baculoviruses. This family includes ORF107 from Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) and a variety of other numbered ORF proteins, such as ORF52 Swiss:Q91F03, ORF140 Swiss:Q9YMI8. The function of these proteins is unknown.	24.60	24.60	31.80	31.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.96	0.71	-4.54	14	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	0	57	0	161.60	54	71.62	CHANGED	olDVD-Fu+QLIADKCssLIEsppMLPtslLullKpA+c-YhcsPoscNYpplK+LhsQTKYV--SI-YKNFNRtlhLIAhphhlNKu+-hFssY..Kshl-sshKRLppINPDlKSSP+AMLpHYpECL-....ph-sP+.tD-HHLloFuKEIhTKIFl-slc.ho.sNpuslshs	..lslDsFA+QLIsDKCSsLIEspshLPsNlLsIlKpARDcYFcsPosKNY-.lKKLh.pTKYhDDSIDYKsFNRRlLLIuhKhuLNKupsaFssY..KsllEsAlKRLspINPDlKSSP+AMLQHYpECLE....NlDsP+.sDEHHLlTFuKEIATKIFl-sl-.aSa.sNpSslph.p...	0	0	0	0
+5503	PF05675	DUF817		Protein of unknown function (DUF817)	Moxon SJ	anon	Pfam-B_7331 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	25.90	25.90	49.70	49.70	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.60	0.70	-4.96	39	378	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	367	0	80	340	18	223.70	50	85.60	CHANGED	phlhFshKQAhuCLFssllhhsLhlT.+ll..shssLsRYDhLLIhsLlhQhhhltotLEThDElKVIhlFHllGhsLElFKlp..hG..SWSYPEtuhhKlhGVPLaSGFMYASVuSYIspAWRha-lchtpaPshahsssLushIYhNFFTHHalhDhRWhLhshshllFhRTaVhFplpssph+MPLlLuFhLIuFFIWlAENIuTFauAWpYPsQtcuWphVcluKloSWaLLlIISh	...............phhhFshcQAhuCLFssllFlsLhlophh....shsslhRYDhLLIhsLlhQhhhlthtLEThDElKVIslFHllGhsLElaKsc..hG..SWuYP..-tuh.KlhGVPLaSGFMYAuVuSYIsQAWRhhclchppaPshhhshsLushIYhNFFTHHalhDhRWhLhshhhllFh+ThVhFpltst.p..h+MPLlLuFhLIuFFIWlAENIuTFaGAWpYPsQhpuWphVHluKloSWaLLVllSh..................	0	23	47	64
+5504	PF05676	NDUF_B7	NDUFB7; 	NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)	Moxon SJ	anon	Pfam-B_7077 (release 8.0)	Family	This family consists of several NADH-ubiquinone oxidoreductase B18 subunit proteins from different eukaryotic organisms. Oxidative phosphorylation is the well-characterised process in which ATP, the principal carrier of chemical energy of individual cells, is produced due to a mitochondrial proton gradient formed by the transfer of electrons from NADH and FADH2 to molecular oxygen. The oxidative phosphorylation (OXPHOS) system is located in the mitochondrial inner membrane and consists of five multi-subunit enzyme complexes and two small electron carriers: coenzyme Q10 and cytochrome C. At least 70 structural proteins involved in the formation of the whole OXPHOS system are encoded by nuclear genes, whereas 13 structural proteins are encoded by the mitochondrial genome. Deficiency of NADH ubiquinone oxidoreductase, the first enzyme complex of the mitochondrial respiratory chain, is one of the most frequent causes of human mitochondrial encephalomyopathies [1].	21.90	21.90	22.50	22.00	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.52	0.72	-4.56	14	256	2012-10-02 15:44:21	2003-04-07 12:59:11	8	6	227	0	183	245	2	65.10	43	53.76	CHANGED	.MlATpEEMptA+LPLt.RDaCAHhLIsLp+CRp-pa.hs.atCccERHsY-pCpY-DalhRhKch-	...........hATpcEMppA+lPLthRDhCAHhLIsLp+C.R.pcp.a.hs...a...pCccERHsY-cCp.Yc-ahhRhtch-............	0	62	102	150
+5505	PF05677	DUF818		Chlamydia CHLPS protein (DUF818)	Moxon SJ	anon	Pfam-B_7510 (release 8.0)	Family	This family consists of several Chlamydia CHLPS proteins, the function of which are unknown.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.21	0.70	-5.72	5	50	2012-10-03 11:45:05	2003-04-07 12:59:11	7	2	27	0	22	183	59	298.60	28	74.67	CHANGED	soILcocP+PplshFSSc+A+puaE+RctHPlLaKILslIhcIlKhLIGLIlFlPLGLaWVLQKlCQNsILPuuuhLhop.phChc....splL+psFlspLcshhppscVSSs+RVsIQpD-LlIDoLuI+lPsAcPcRWMLISLGNS-sLEshshlttcc-...SlpclAKtsGANILVFNYPGVMSSpGsloRENLuKAYQACVRYLRD+.sGPpA+QIIAYGYSLGulVQAtALsKElsDGSDuToWlVVKDRGPRSluAlAsQahGsIGshlAsLsGWsIcSsKpSc-LsCPEIFIYusDp.cssLIGD.GLFp+EsClAsPFL-sPpl.chsGsKIPIuEpsLpHpsPLccsTIpcLAssIlc+LS	.....................................................................................................................................................hthhKhlh.hhh..P.slha.h..hs.t..lhst....h............pphhp..a.h.tthpt...h.ppt.h..s...phpRlsIp.t..D.plhlDsht.l.p.h.s.....p....A....+ss.R.W.hLhuhGNupsaEp..hh....s....lhplAKp...h.....p..uNlllFNYPGVhpS........pGps..s.p.c.s.LspuapAsV.+.YLcDp..pGspAcpIlsYGaSLGu...u..Vp...A..t.ALppp.hp..sp-shpahhlKDRu.pSlushA....pp..........hh...s.......l.s..thhhp....lh...sWphs....u.K.ucpL...s...-l..hh.......hth......s............t....p........l.tc.thh..p.shAt.hhp.........pK..l......c.t.l..................................................................................................	0	12	12	20
+5506	PF05678	VQ		VQ motif	Bateman A	anon	Pfam-B_7960 (release 8.0)	Motif	This short motif is found in a variety of plant proteins. These proteins vary greatly in length and are mostly composed of low complexity regions. They all conserve a short motif FXhVQChTG, where X is any amino acid and h is a hydrophobic amino acid. The function of this motif is uncertain, however one protein in this family has been found to bind the SigA sigma factor Swiss:Q9LDH1. It would seem plausible that this motif is needed for this activity and that this whole family might be involved in modulating plastid sigma factors (Bateman A pers. obs.).	20.40	20.40	20.60	20.90	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-7.23	0.72	-4.91	49	612	2009-09-11 20:58:54	2003-04-07 12:59:11	9	6	26	0	403	538	0	30.40	35	13.43	CHANGED	thhsspllps-sssF+slVQcLTGtssssss	.............hssphlp.s-.ss.sFRslVQcLT.Gtssss..........	0	56	239	327
+5507	PF05679	CHGN		Chondroitin N-acetylgalactosaminyltransferase	Bateman A	anon	Pfam-B_8249 (release 8.0)	Family	\N	19.70	19.70	20.40	19.90	18.90	18.30	hmmbuild  -o /dev/null HMM SEED	499	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.70	0.70	-5.79	13	643	2012-10-03 05:28:31	2003-04-07 12:59:11	11	14	100	0	386	631	1	400.30	22	63.56	CHANGED	HlssCl+shhSs+cD.VplGRCVpchuGl.sCshsa..Qulhacsaphs........hcuastph+scph+sAlTlHPlpsPshhYRLHsYhtpl+lpchppcphtLcp-ltphoph.tsps.tpsphP....................LGlsPs...hpPpsRp-llpW-als..+phh.uscss.P+pplcusp+p-lsDllspsh-plNpptp....sl-F..+pLhhGYRRhDsh+GhDYhLDL........Lhh++tRG++............hsVpR+hal.+shoc...................................................lEll.sssasscu............oRlslllPLsu+..sshhh+FlcsaEpsCLcs..ppsstLhllhahcss-spphsp.......pplhppLcs+a..ssu+lsalslp......................ssshSpslAlDlAs+..+hsh-oLlhlssschsFps-FLsRsRhNTIpGhQlahPIsFspYcPch.........................tp...psstsss.hclspss..........GaFcchuaulsuhYpuDhlpuchthhsp...................chps.GlEslclh-hhlpss.p...................................l+VhRusEPuLVa........la+slsCD.ssL-ptphchChsoKsps....luSpcpL	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................th......a...h...........h...........t.......pp.........lp....t........p...t..tl....-...s.lt.tshc.lNpp.p..................hh.ph.....pc.l.hp..G..h...hRh-.h+......GhcYh.Lch.........h...hptp......p................................h..h+..+.h..l..hp.s.hu.t...............................................................................................................l.hl...s....h.....htp........................................shlplllP......ltsp..hc.hh.pFhps.atph..shps....pppshLhllhhhp...p.pt.h.tp............thh.tphp..p.ch......shtphphl..tlp............................t..thscstuLp.hu.sc........th...s...s.c.s..LhFhsDl.chhhsschLpps....Rhps.....l.GhpsaaPlhFppasPth...................................................t................tt....sh.ppts.............G.aacp.uaGhsshYpuDahph...tth.s.........................phptWGhED.h..c..lhcthlpss...........................................LclhRs...ulhp..............ha.+..h.C.........s......p..hs.t..hphCh.sth.t......uuh..................................................................	0	115	143	250
+5508	PF05680	ATP-synt_E		ATP synthase E chain	Moxon SJ	anon	Pfam-B_6116 (release 8.0)	Family	This family consists of several ATP synthase E chain sequences which are components of the CF(0) subunit [1].	21.00	21.00	21.00	21.20	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.10	0.72	-4.03	17	264	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	228	0	172	254	0	78.20	28	86.96	CHANGED	hss...SPhlpssRaSALshGlsYGhh+hppLp...cpcpct+chctppthltptKht.tK++pscpc..hpthspuop.....................shht	..........h......SshlplhRaSALshGlhYGhh+.ptLp...cptptp+chctcpphlppsKtthtKpht..t..................................st.t..................................	0	50	90	135
+5509	PF05681	Fumerase		Fumarate hydratase (Fumerase)	Moxon SJ	anon	Pfam-B_2085 (release 8.0)	Family	This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre [1].	25.00	25.00	25.70	25.50	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.63	0.70	-5.32	170	3534	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2307	0	710	2256	603	274.30	41	60.95	CHANGED	ltcsltchhpcsshhLssDhhpulpcAhcpEcush.u+tsltplLcNuclAspt..........phPlCQDTGhssl.FlclGp.pVphss...slp-slscGVccuYp..-ssLRhShVtc.Ph.pRpNTsc....N....sPAllchchl................sG...-plclphhsKGG..GSENhotl.....thL........sPup...ultcaVl-sltphGss..sCPPhhlGlGIGGTs-cAshLAK+.ALh+.lsptp..s..........chtcLEpElh-plNpLGIGsQGhGGpsTsLsV+lpphP...sHsAShP.VAlslsCtAs.R+sphpl	.................................p.hstpAhpcsSahL.ssahppltp....hh.cc..c..........ust....sKhlhhphLcNuclAAcs..........hhPhCQDTGhsh.l.hsKhGpcVhhsG..........s.cpslscGVhpuYh..-ssLRhStss..s.shhcchNTGs..........N....h.PA..lch.h.V........................................................sG.....Dc..hchhshsKGG..GStNKohh................shL........sPu............slts.all-p.h.po....hGsu..ACPPh.hlulsIGGTutcsslhstK.A.h+..lDph..sstt.............u...+shcLEpELh-psppLGlGAQ.hGGphhshDl+lhphP....RHuAShP.VuhsluCu.As.Rph+hpl....................................	0	239	456	591
+5511	PF05683	Fumerase_C		Fumarase C-terminus	Moxon SJ	anon	Pfam-B_2085 (release 8.0)	Family	This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth [1].	21.80	21.80	22.00	35.20	20.10	21.70	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.30	0.71	-5.19	72	3515	2009-09-10 16:06:45	2003-04-07 12:59:11	7	8	2299	1	713	2175	505	198.00	43	47.11	CHANGED	GoGsspLpsPs...lcpaPcl.shcss...sss..............................+R..VsLss..lTc..--lppacsG-sLLLoGcllTGRDAAHK+lh-h.lspGEsLP..VDhcs+hIYYVGPV...DsltcEsVGPAGPTTuTRMDpaTcphLcpsGLhuMIGKuERGstsl-AI+cHtusYLhAlGG.AAaLlu+uIKpucVVuFt.-LGM.EAIacF-VcDM.PVoVAVDscGsulHppuPtp	..............................................................G.h.t.Lp........hp.hPt......t.........tps.................................hclsLsp.Phpc....ppL.sph.luspl.LoGsIls.uRD.h.AHt+ltEh...l....p.p.......G......c..s......LP...............l..+..s..+sI..YYAGPs.............css..s..shssGS......hG..PTTusRMD.s.a.sc.p.h..sp.sGshlMluKGsR.u.p.p.sp.-A.C.+KHsuhYLsulG.G.AAsLuppsIKcl.E.sV.tas.ELGM.EAIWcl-V-DF.PshlhlDs+GNshapph..p..................	0	244	461	596
+5512	PF05684	DUF819		Protein of unknown function (DUF819)	Moxon SJ	anon	Pfam-B_9034 (release 8.0)	Family	This family contains proteins of unknown function from archaeal, bacterial and plant species.	20.70	20.70	21.60	21.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.95	0.70	-5.64	6	548	2012-10-02 17:06:44	2003-04-07 12:59:11	7	5	422	0	194	501	310	333.30	25	86.51	CHANGED	uhLhuhuAhslWs...Ec+sKht..usVsuhllshLluhhhsslGLl...sspossasslhshLLPtsI.LLLhpsDLR+Il+.us+LLhhFLluSluhhlGsllAahlhp.h....lusDsW+hsAALhGSaIGGusNhlAhpssLsVssoshusulssDslhhulahhlLhhLsuht...pttshA-TsplpussschspspspEc+psss.schhhhlulShhlsuluthlushh.......h.hul.....susshsslhusslsLlhuFsshhsh..PuupcluplLlYshhsllGususlhslls.APhlhLauhhhlhsHlslhLulGKLF+l-LphlhlASpANIGGPsoAsshAsAhs.suLlssGlLhGlhGhulGTalGlhhG.hlpph	.............................................................hlhh.hhuhhhhh.......p..p.....hh.h.t.......thlsuhl.hhhhhshlhsshs.lh........................................................t..s....ha..h.h.phllPhsl.lhhh..phDl+.........t.l.hp......u..s.+hlhhFhhu.shuh.hl.....G...s...l..uh...hl...h.t.h..................h....s.c........h........h.........p..h....h..us....lsuS.al.....GG.usNhsAht.p.......h..h...t......s..s..s.....s....h.....huhhlssDslhhslahhhL...hhhss...h...t....h...h...p..t...h..ht.s...c.t.pt.h......p....t.....h...t.....p....p...h............t.t........t....t...............t...p............................s..hhh.hl...u..h.u...hhhs.s..lup....h....hushh...............................h..................t.ha..hllhsh...sl.u..lh.h..s..h.....sp.....h...h.ph........s..Gu.pp.lushhlY.l.hlsslGh.th.s...lt..t.l...ls...s.Ph...hh...l.h.u..h..l..h..l..hlHhh.l.hl....h...lu.+.lh+...........h..............sl.....hh.lhlASp.ANl.GGsso.A.ss......hAs....Ahp..suLsssulLhullGYslGsahGhhhu.hl...h.............................................	0	70	128	167
+5513	PF05685	Uma2	DUF820;	Putative restriction endonuclease	Moxon SJ, Bateman A	anon	Pfam-B_7809 (release 8.0) & Pfam-B_8730 (release 14.0)	Family	This family consists of hypothetical proteins that are greatly expanded in cyanobacteria.  The proteins are found sporadically in other bacteria.  A small number of member proteins also contain Pfam:PF02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.28	0.71	-4.90	170	4083	2012-10-11 20:44:44	2003-04-07 12:59:11	7	12	450	7	1583	4539	272	163.40	17	81.91	CHANGED	hp-a.hphs........ttth+hEh..hsGplhh..h...sshs.shHsp.hsstLhttl..t.h..hpt..ths..hshss.shshph....................tts.h.PDlshhptp.......hpphspt...................shsPslllElhSsssp...t-.htp.................KhthY.......t.thGlttaal......lD............spppp.......lplaphs..tt.......tap.hph......ttsphhph..sls.sht....lslp	..................................................................th..th.........t..t...p.h.Eh..hpGtlh.......h...........ss.s...Htt..h.ttlh.....thl.....tth.......hpt.....t.s......hhhhs..shtlth......s.............tpshhtPDlh.lhttp.........tph.pt...............................hstsPplllEll........S...s.u...sp...tDhtt.........................................K.h.t.h.Y.......t..phG.ltcYal......l-..............s.p...p...p.p...........lp.lapht....tt........tat....th........t...t..h....................t...............................................................................................	0	486	1227	1544
+5514	PF05686	Glyco_transf_90	DUF821;	Glycosyl transferase family 90	Moxon SJ	anon	Pfam-B_6682 (Release 8.0) & Pfam-B_7101 (Release 8.0)	Family	This family of glycosyl transferases are specifically (mannosyl) glucuronoxylomannan/galactoxylomannan -beta 1,2-xylosyltransferases, EC:2.4.2.-.	20.50	20.50	20.80	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.28	0.70	-5.78	19	1264	2012-10-03 16:42:30	2003-04-07 12:59:11	7	25	380	0	784	1222	143	256.40	18	53.19	CHANGED	s..ps.sCPsYFRaIccDLcPWcps.GI..oR-hlcRu..+ppAthRlsIlsG+lYlcpaccshQoRDhFThWGllQLLRcYsG+lPDlELhFsCsDhPhl+ptsap.t.......sPPPLFpYCusspolDIVFPDWSFW.GWsEl......Nl+.WshhhtclpcusscspWpcRtPhAYW+GNssVsp..Rt-Ll+Cs.hos.p.hsAclhpp............................Dhs.t.c.uh+pssl.spCpa+YpI.l-GhAhShp.KYILuCDShsLhlps.Yh-FF.+sLhPhpHYhPlcsttc..spsl+.tlpWupspsptApcIucpGSpFlpccLpM-hVYDYMaHLLsEYAKLL+aKPplPpsusElss-shsC.hp.....Gh.+phh.pSh...sssps.PCph.PsPhp..tht.hhp+ptp.h+pVcphE	.............................................................................................................................................................................t.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.......t...........t...........a.t.p.+....shh.h.....a+....G..........t.........t.............t.................................R.........t...h...h..t..h.......t..............t..........................h......t.s.thh.t.............................................................p.t.t.............hh...p........h...s....h.t-...t...h.......p.aK......Y...l..l..sl..-.........G...s.s...h.S.s..p...h...thl..htssSlsl.t......t.....s..h..........a........h......................-.....aa.....h...p...............t........L.....h.....P...h....h....H....Y..l..P...lp..p.......s.................hp-....l........p...........h....l...............p........a................h.........p..........p........p.......s.........p.....t...A...p...pIu.p.p.u..p.p.ahp............p.....lp..tt.h......Y.hhpl.h........pauph............................................................................................................tt.....................................................................................	0	263	474	641
+5515	PF05687	DUF822	DUF822; Peptidase_M15_2; 	Plant protein of unknown function (DUF822)	Moxon SJ	anon	Pfam-B_7149 (release 8.0)	Family	This family consists of the N terminal regions of several plant proteins of unknown function.	25.00	25.00	26.20	25.70	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.18	0.71	-3.85	15	154	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	22	0	105	163	0	141.80	46	37.09	CHANGED	uuusRpPTW+ERENNK+RERRRRAIAAKIauGLRApGNYsLPKHCDNNEVLKALCpEAGWlVEsDGTTYR...KGs+Ps...t.-hsGsSss..sSPsSShp..........SPhsSYpsSPsSSuFPSPoph-.hsht..........ssllPaLpshs.........ssSuhs	.........ussRhPoW+ERENNK+.RERRRRAIAAKIauGLRtaGNYpLPKHCDNNEVLKALCpEAGWsVEsDGTTYR..........KGs+Ps.........phhGs.Sss.....soPpSShp..........SPhsS.pssst.ssphsSssp.s.......................h.s............sss..................................................................................................	0	15	66	86
+5516	PF05688	DUF824		Salmonella repeat of unknown function (DUF824)	Moxon SJ	anon	Pfam-B_2973 (release 8.0)	Family	This family consists of several repeated sequences of around 45 residues.	23.80	23.80	23.80	23.80	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-8.15	0.72	-4.32	25	1631	2009-01-15 18:05:59	2003-04-07 12:59:11	6	24	187	0	31	888	3	47.80	36	14.57	CHANGED	Dush...s....AuKsKpGEslslsVTs+Du.sG.sPlssssFsLpRscuhsRpss	.................stsh...s.......AuKsKtGEslslsVTs+Du..sG.sPlssssFslpRu.suhsRps......	0	0	0	13
+5517	PF05689	DUF823		Salmonella repeat of unknown function (DUF823)	Moxon SJ	anon	Pfam-B_2973 (release 8.0)	Repeat	This family consists of a series of repeated sequences (of around 180 residues) which are found in Salmonella typhimurium and Salmonella typhi. Sequences from this family are almost always found with Pfam:PF05688.	21.00	21.00	21.20	21.40	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.47	0.71	-4.94	30	1826	2009-01-15 18:05:59	2003-04-07 12:59:11	6	36	210	0	42	1044	6	180.10	34	58.02	CHANGED	GhTsAsGpsolsloQssuhGlKTslsAslssssssoss..hsVIFTVlTSPDospApMWGHMs-TlTs....sGhsF+RPhLsuEhsusss.......ohh-sNEsWuh.hs...sth.ssssst..Cs.hshlPshspLpuLYsspssst..lpTshGWPstts........YhSuspsssss.......apsls.LssGspsshsssss...shhoCl	..............................................GhTsusGssolslsQs.suhGl+Tslssshhs..s..s....ss..oss..hsVIFTVlTSPDos...pAphWGHMs-TlTs....sGhsFcRPh.LtuEhsusss........shh-sNEsWut.hs.....t.tssssst......Cs...hshlPs...hspLp....uLYss....h...s....ss.s....l.poshGWPspts...........Yhuu.spsssss.......atsls.Ls.sGsps.psssss.....thhoCl....................................	0	1	2	22
+5518	PF05690	ThiG		Thiazole biosynthesis protein ThiG	Moxon SJ	anon	Pfam-B_1138 (release 8.0)	Family	This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.39	0.70	-5.30	28	2805	2012-10-03 05:58:16	2003-04-07 12:59:11	9	11	2724	15	705	5198	2724	239.00	49	90.63	CHANGED	pIus+sFsSRLllGTG+YsS.plhpcAlcASGspllTVAlRRhstss..stssllchlc.pshplLPNTAGCpoAcEAlpsA+LAREsh......sssalKLEVIuDs+pLhPDshpTlcAAEhLlc-GFtVLPYsssDsllA++Lc-sGCuAlMPLuuPIGSGhGlpNhhsLclll-ps.cVPlIVDAGlGsPS-AAtAMElGsDAVLlNTAlApApDPlsMAcAhthAV-AGRlAa.AGhh.p+c.hAsASSP	..................................................................................................................h.IuscpFsSRLhhGTGKaso.plhpcAlcASGupllTlAlRRhsh.....t..p.......................p.............sslLchl......ts.......lslLPNTuGs+oAcEAlhsAcLAREsh.......sosalKLEllsD.s.+..hLhPDs..lETlcA..AEhLl.c-GFh.VLPY...s..s.sDPl.l.s.+R...L..c.-.s..GC.u.....A....V....M....P...L...G...A...P...I.....G.........S.........s...p....G..........l..........t..........s...............t.........h..........L....c...l..........I......l...c.....pu.....s......V..P...V..l..V..D..A..G.IGsPS......c......A....At.AM.E.h.G.sD.AVLl...NT....A...I...A...t...A...pD...P...l....t..MAc...Ah..+.h.A.V.-....A.GRhA..a..AGh...hs..p..p.p....h.A.pASSP.....................................................	0	222	452	596
+5519	PF05691	Raffinose_syn		Raffinose synthase or seed imbibition protein Sip1	Moxon SJ, Eberhardt R	anon	Pfam-B_3204 (release 8.0)	Family	This family consists of several raffinose synthase proteins, also known as seed imbibition (Sip1) proteins. Raffinose (O-alpha- D-galactopyranosyl- (1-->6)- O-alpha- D-glucopyranosyl-(1<-->2)- O-beta- D-fructofuranoside) is a widespread oligosaccharide in plant seeds and other tissues. Raffinose synthase (EC:2.4.1.82) is the key enzyme that channels sucrose into the raffinose oligosaccharide pathway [1]. Raffinose family oligosaccharides (RFOs) are ubiquitous in plant seeds and are thought to play critical roles in the acquisition of tolerance to desiccation and seed longevity. Raffinose synthases are alkaline alpha-galactosidases and are solely responsible for RFO breakdown in germinating maize seeds, whereas acidic galactosidases appear to have other functions [2].\	\	   Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K [3]. This family includes enzymes from GH36C.	20.00	20.00	20.10	20.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	747	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.28	0.70	-7.00	11	570	2012-10-03 05:44:19	2003-04-07 12:59:11	7	15	210	0	281	620	6	368.90	23	73.23	CHANGED	hsls-upLhl+s.pslLocVP-NVo....uo.ssss....s..........ssspGuFlGFots.cscS+HlsolGpLcsh+FhSlFRFKlWWoTQWlGpsGpDlphETQalllEhs......p.s.......pt.csYlVlLPllEGsFRouLQsGcsDcVcIClESGSopVcsSoFpsllYlHsussPapLl+-Ah+Al+sHLsTF+hLEEKolPulVDKFGWCTWDAFYLsVsPpGVhcGlKsLu-GGsPP+FVIIDDGWQSIspDsc...c..DutNlVhuGpQMssRLppacENpKF+cYcss..............................................................................s..ppssGhKuFlcDLKpcFpul-pVYVWHALsGYWGGVRP..tssc.h-uplh.PpLSPGltuTMtDLAVDcls.tGlGLVpPcpAp-hY-ulHSYLussGlsGVKVDVhplLEhLuppaGGRV-LuKAYacALosSlsKNFsGNGsIASMpHCNDFhaLuTKQIulGRVGDDFWspDPsGDP.GsaWLQGlHMlHCAYNSLWMGpFIQPDWDMFQSsHPsAEaHAASRAIuGGPlYVSDslG..sHNFDLLKKLVLPDGSILRspaauLPTRDCLFcDPL+DGpolLKIWNhNKasGVlGsFNCQGAGWs.cs++s+sasEsspsloGol+scDlEWpsptss...phshst-asVYh.ppuccLllhs..ussl.lTLcshpFELholsPVpcls.ttslpFAPIGLlNMFNSGGAlp..slcassp...........................sVclcV+GsG+FtAYSSp+Ph+Ctl-Gs-lEFpYps-.GhVslpl	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hht...sMt.....s.............................................................hRsu.....D....ah.......................Hh...shhsshh.h.t.....h.h....sDaDMF..................o........p...........................ut......h.hu..+hhsGsslYloD...s....t..........th............s.......ht.lt.h..h..................................................................................................................................................................................................................................................................................................................................................................................................................................................h............................................................................................................................................................................................................................	0	71	176	235
+5520	PF05692	Myco_haema		Mycoplasma haemagglutinin	Moxon SJ	anon	Pfam-B_3547 (release 8.0)	Family	This family consists of several haemagglutinin sequences from Mycoplasma synoviae and Mycoplasma gallisepticum. The major plasma membrane proteins, pMGAs, of Mycoplasma gallisepticum are cell adhesin (hemagglutinin) molecules. It has been shown that the genetic determinants that code for the haemagglutinins are organised into a large family of genes and that only one of these genes is predominately expressed in any given strain [1,2,3].	20.00	20.00	22.50	22.20	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.79	0.70	-5.77	31	148	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	6	0	49	106	0	382.60	42	66.32	CHANGED	spAlS..pLps.KsNA-phAstFhKpsLsKspLous.............tssspp...QPuNYSFVGYSVDlss.............tppshPNWNFAQRpVWsussp.ss..........................................................stspssssLTDVSWIYSLu...GssuKYTLoFsYYGPo.TuYLYFPYKLVKsuDs.pVuLQYpLNssss.ptIsF............................................s..t..t.ttt...sspssssssphNssPTVs-INVAKVoLosLpFGpNTIEFSVPss......KVAPMIGN......MYLTSs....ssNpsKIYs-IFGN.s.sppsssouVTVDLLKGYSLAosaSTYltpFosL......sssssppssssYLlGaIGGss..sRsssss.........sNh.psPssssss....RTaTIYVNAPpsGsYaISGuYl........osssRsLpFsh....ssssss...NsVolsshspsNWoT....LuTFDT.............ssssssssossssc+TLsLpKGLNKIlluGs.....ssssAPaIGNLTFTLps	..........t..shp..pLpp.KpNAsphss.F.KpsLs+splsus.............tspsptQPuNYSFVuYSVDlss..............tpt.PNWNFAQRpVWsssst.ht..........................................................sttpssssLTDVSWIYSLs...GsssKYTLsFsYYGPs.TuYLYFPYKLVKsuDp..VuLQYpLNssss.ptIpF..................................................................sstssths.sPTVssINlAKVsLosLpFGpNTIEFSVPts........KVAPMIGN......MYloSs....tsNpppIYssIFGN.s.sppssposloVDhLpGYSLAosaSTaltpassh.......sst.ppsp.hYLlGalGGss..sRsshss..........Nh.p.P.ssssp....RTaThYVNAPpsGpYaIpGsYh........osssRsLphps.....sstss...NslTls.h.tpsNasT....LtpFDT.............ttsssssss.ssss++TLsLpcGLNKIll.uGs.....sssssP.lGNLsFTLp.................	0	48	48	49
+5521	PF05693	Glycogen_syn		Glycogen synthase	Moxon SJ	anon	Pfam-B_2874 (release 8.0)	Family	This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3 [1,2]. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P) [3].	19.10	19.10	19.10	19.20	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.23	0.70	-6.28	7	829	2012-10-03 16:42:30	2003-04-07 12:59:11	8	5	520	24	319	797	26	398.40	37	87.51	CHANGED	EVAWEVANKVGGIYTVl+SKA.Vos-EhGDpYshlGPhp-psh+sEVE.lEspsss........l+tslpuMps+GhplhaGRWLIEGsPpVlLFDluSuAatLscWKs-lW-tCpIGlPapDpEoNDAllhGahlAhFLtEFpspsp.........s.tVlAHFHEW.AGVGLhLsRt++lsluTlFTTHATLLGRYLCAGu.sDFYNNL-pFsVDpEAGKRpIYHRYClERAAsHsAHVFTTVScITulEAEHLLKRKPDllTPNGLNVhKFuAlHEFQNLHA.sK-KIp-FVRGHFYGHlDFDLDKTLYFFhAGRYEFsNKGuDhFIESLARLNahLKssss....csTVVAFlIhPApTNsFNVEoLKGQAVhKQLcDTlsplpcplG+RlF-pslp....Gp....lP.-hc-LLppsDhlhlKRslhAhpR..poLPPlsTHNMlDDusDPlLssIRRspLFNpptDRVKVlFHPEFLSSssPLlslDYE-FVRGCHLGVFPSYYEPWGYTPAECTVMGlPSlTTNLSGFGCFMpEplp..-spsYGIYIVDRRa+uh--SlpQLspaha-FsppSRRQRIIQRNRTERLSDLLDW+pLGhaYhcARphALp+saP-.a.h...sphhssst.........h+hsRPtSsPsSP..........osuphuS.psS-sEDs.	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................suhuh.h........hch.....th......lsT..lFTTHAThlGR.ls..uss..hshYs.L..as..........hDt.A.tc........h.........tl.p+ashE+tusH.scsFTTVSpITuhEspcLLc+ts..Dhlh.P.NGhp...s..hhst.h...ppFpsh+t.t+t...+l.phspu...c...h.hG....p.....................s...h...p...-.p.TL.hhhhuGRYEatNKGhDhFlEuLsRLNh......hp..tt........phsVlAFhhhPs.............................................................................................................................PhhTH.h....h.s...pD.lLs.l+phthhNp.tD+VKllFhPpaLs..ussslhsh-Y....-hl...h....Gsc...L...slasS......................................................................................................................................................................................................................................................................................................................................................................................................................................	1	100	174	261
+5522	PF05694	SBP56		56kDa selenium binding protein (SBP56)	Moxon SJ	anon	Pfam-B_2816 (release 8.0)	Family	This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 participates in late stages of intra-Golgi protein transport [1]. The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role and can be implicated in controlling the oxidation/reduction status of target proteins, in vesicular Golgi transport [2].	19.70	19.70	19.70	19.70	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	461	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.55	0.70	-5.99	28	437	2012-10-05 17:30:42	2003-04-07 12:59:11	6	7	298	1	210	468	423	379.30	42	93.69	CHANGED	hpssPs.YsoPttAh.puPtEclsYVssl.ssss..+.PDhLAsVDVDPpSsTYupVlpRl.hPshGDELHHhGWNAC.SS..Ca..scsst...ERRaLllPuLpSSRIYllDT+sDPRpPpltKlIEPpElhp+sGhopPHTsHChssG.IhlSsLG..ss-G..sGsG.GhhLLDp-TF-lhGpWEhsptsthhuYDFWap.tassMloSEWGsPsthccGhsspclhsG.pYG++LHhWDhsp++hhQolDLG.s-sthsLElR.hH-PscshGFVGss.....LSuSlapaa+.-c....sp.W.sscKVIslPuc.s-..u..LPsh......................PsLlTDI.lSLDDRFLYlSsWhpG-lRQYDlSDPtpP+LsGpVhlGGllp+u................shPsspsppLsGGPQMlplShDG+RlYlTNSLYSuWDcQFY.P-hl..GuaMlplDlDsct.GGLsls.sFaV...DFGpt....hhAHplRh.GGDsoSD.ah	........................................sPs.a.oP...Ah..p.....u..PtEplhYh.sl..........st......s...ts.....DhluslDlcPpS.ssYsp....llpph.h.s.hsDELHH.GWNsCSS..C.....scsth....pRphLllPuLhSuRlYllDst.-P....ptPplh........K...........l..l-sp-lht+sshuhPHT..sHChs..sG.lhlSsLG.....s.cG..su.G...GhlllDs-.................F...........plh.G.pW...........Eh......s...........t.......t.s...........................huYDFWap..t+ssMlSo.-Wu..sPs..hhp...p..Gh..s....tc.lts.s..hYG....pplahWDhptpchhQolcLG.t.p.t.hsLElRhhHsPsts.GFVGss.....Lsuslhpaa+....p.s................up..WphccsIplss..sp.sh.LP.h......................PsLlTDI.lSlDDRaLYhssWhpG-lRQYDloDPtpPhLsGplhlGG.l.cs.............................h....psppltG.GPQMlp.lS.hDG+RlYhTsSLausWDc..QFY.Pc.hh.........su.h..hl..........lc.ssst..GGhpls.sFhV...DFsp....t........hhsHphRh.GGDsooD.ah....................................................................................................................................	1	60	99	164
+5523	PF05695	DUF825		Plant protein of unknown function (DUF825)	Moxon SJ	anon	Pfam-B_8370 (release 8.0)	Family	This family consists of several plant proteins greater than 1000 residues in length. The function of this family is unknown.	18.10	18.10	19.40	18.10	17.90	17.90	hmmbuild  -o /dev/null HMM SEED	1390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.50	0.69	-14.39	0.69	-7.17	7	1423	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	537	0	50	1419	2	520.60	26	64.48	CHANGED	MKcQp....hK.hIhEL+EI.+p.+s.pahhcSWTphNSVGohI+IFF+pERhlKLFDPRIhShLLSRNhpGSpSNpaFTIKGVlLhVluVLIYRhNp+.NMVERKshYLptlhPIPhN.ht.tNDT.EEuhGsoNhNhLIhs..LL.hPKGKpI.Es.hLsspEsThVLsITKht...............................pt.lAtI-..hKEKt.p.Lch........................................................................................................................................................................................................................pLKtS.s..h-hh-slp.EsSEYts.hNp+-...........................................................IpQ.cEcu..WcP.S.lphERpc............................c+.h.pphhPcEhc.cFlGN.T+SlRsaFSDRWS..ELaluS.....sPhE+.Th-pKLLKpp..lsFV..RcSEs....pEIlsLaKIITYL..QpTsSIauISSDPGhshl.Kpp.Dhsp......hpKN.hFshhphFa-ps+...hhcpsFcS..EERlpEhsDLFTLsITEPD.VYcptau...a....s.YtLsppphL..sclhNpRsc.KppSLhlL.slh...-ctc.ahcRIhpK.l..Isstp.....+.Khss.hsp.hhEuls..chIpshI.......puYlRslhNRFahhN+SsRNhc.tIppsQhGs-sLNpRThMKhpIppc..............................sYh.KWSsuocshQEaLEHFlSE...........QKscFpssFD.h.........................phphsp..IsWStshcK..KDh............s+..hh............hh.K.hhFhoKhlhhLuNsLshFh..VShGNhPIpRSEIpI.ELKGsscpLC.......NpLLESIGhpIVHLKKLKP..hLL--ass...SKFlIstuThu.Fh.NclP....hID.hpscpNp.cSFDNpDS.FShI.pDp-NWLNPsK.FppSSLIuSFYKAN+LRFhspsHHFpF.CpKRFPFsVE+s+.pNpsahYGQFLNlLhl+pKhFSLClGccKHsahp+sTISsIES........QVSNIFIPpDF...QSG-pp....YsL.KSFph.o+ssPhV+..RsIYSIh-hSsTPLTEsQIVNhERT.CQPh.D..hNLSDSEtpNhcphLN..FsSNMGLIHo.hS-c.L.SE.....KcKppsh..pl+ct..............................................scKtpMaphhQpDShFShLS.KWNLFpTYhP.FhTSsGYKYLs.lFLDsFS-lL.hhSpt.....VSIh........pDIh.......slSWcILQ.chshhph.lpoE............Ipppahp..NlhLucEhI+RN..sps..h.THLR.sNshEFhYSILhLlhVhGYLlhhalhhVSpAF.ELQp-hcplKSLM.PS.h..IELRKLlD+YP.SE.NSFhLKNlhlhshpplt.Sl.p.Rthuhshph.........l.ulhtpppshNlshID.p.llshlsss.spIs.ptsshplSHsu	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	3	30	41
+5524	PF05696	DUF826		Protein of unknown function (DUF826)	Moxon SJ	anon	Pfam-B_7303 (release 8.0)	Family	This family consists of several enterobacterial and siphoviral sequences of unknown function.	25.00	25.00	26.50	28.10	21.50	18.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.73	0.72	-3.84	3	296	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	140	0	1	137	0	78.60	72	87.10	CHANGED	MSEITSLVTAEAVKEVLRSEEVpSALKQKLRHNLEARLDAEVDAILDELLGs.AuP.sE..AG-oTAsD......s.ss-usEP.QP	.MSEI..TSLVTAEAVK-VLRSEEVRSALKQKLR+NLEARLDAEVDAILDELLGss..AsPtsE......AGDsoApc...........usEP.pP................	0	0	0	1
+5525	PF05697	Trigger_N	Trigger;	Bacterial trigger factor protein (TF)	Moxon SJ	anon	Pfam-B_8447 (release 8.0)	Family	In the E. coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains [1]. This family represents the N-terminal region of the protein.	21.30	21.30	21.50	22.20	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.66	0.71	-4.39	152	4472	2009-09-11 09:24:54	2003-04-07 12:59:11	8	7	4374	14	995	3073	2205	145.40	31	33.23	CHANGED	Mpsphp.p.hsshpt.plplplsspclppplppthpchs+....psplsGFR....GK.VPh..pl.......lcppaGp.p.lhp-slpcllp...cshpculpc....p....plp.sl.upP...pl............p.hp....hppsps..hp...ashph-lhP-l...clss.hcsl...pl..pp.ts.pls-c-l-pplcplp	....................MplohE.p.hpshpt.plolslss-plcstlcpthpc.lsK....p.l..p.lsGFRK..........GK...V..Ph...sl.......lcp+..a....G..t.p..lhp.-slsplls....csatcA.lp-..........p.plp..sl..upP.....pl...............ss.tp......hc.p.Gcs.....ht....assphpVhPEl...c.L..ss...h...c.s...l...cV..cc.ss..-VoD.p-V-ptl-pl...............................	1	347	667	850
+5526	PF05698	Trigger_C		Bacterial trigger factor protein (TF) C-terminus	Moxon SJ	anon	Pfam-B_8447 (release 8.0)	Family	In the E. coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains [1]. This family represents the C-terminal region of the protein.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.40	55	4501	2012-10-02 13:36:56	2003-04-07 12:59:11	9	11	4242	11	991	3166	2160	155.90	23	35.84	CHANGED	oL--L+ppl+cplp.cphppthppphccpllctLlcpscl...-lPpuhlcpEhsph....hpphtpph.t.tGhshpph.p..t...stcphccphccpAc++V+hsLllsclucpcplplo---lppplpchAp.pYs..h.pspplhphhtpptpht....tlcsslhccKsl-hllp	............................................................ol-cL+tcl+cplp.cph.cpt.hc.sp...h+ppsl-tllcs.s.cl....-lPpuh...lcpElcp....h..............hppht........pph...t...G...h......s....cp..........t..........st-p.....h.+c.phcc....p.Ac+RV+hs.Ll.....L.s....tl....s..cs..cp..l..c..ss-.--...lpp.t.......l.p......c.hAp....pYs...........ss..cp.......lh......p...h...h........pptph......tl+pslhpc+sl-hlh.t....................................................	1	347	658	841
+5527	PF05699	Dimer_Tnp_hAT	hATC;	hAT family C-terminal dimerisation region	Albrecht M, Bateman A	anon	Albrecht M	Domain	This dimerisation region is found at the C terminus of the  transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerisation region forms extremely stable dimers in vitro [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.63	0.72	-4.36	49	2390	2009-09-11 20:57:40	2003-04-07 12:59:11	9	113	188	1	1830	2467	15	79.20	19	15.44	CHANGED	-LcpYhp-.shhp.p.........hclLpaWp...tppscaPhLophApclLulPloosuu..EpsFSss..s+hlsct+splp.pslpuLlshcphl	.....................................................................................s.h.t..aWt........tpp.tp.aPt....LtplApp....l..L.s.lPsoosss....ERsFSsh......tph.h.s..c.p.Rsplp.pphpt..lhhhp.......................................	0	435	1044	1597
+5528	PF05700	BCAS2		Breast carcinoma amplified sequence 2 (BCAS2)	Moxon SJ	anon	Pfam-B_7922 (release 8.0)	Family	This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins [1]. BCAS2 is a putative spliceosome associated protein [2].	21.20	21.20	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.36	0.70	-4.88	18	311	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	249	0	219	303	7	197.40	30	87.94	CHANGED	hss..p............hlDuLPYlDpthp.pssh..+pt....uspLlp-Eh+...phtsstshhpplP...tsshp.h.p.slhpsEh-Rhppt.....pP.httlDh.pRYclPtPsuspts....c.ptWppslpsutsthpHpshRhpNLELLscYGssuWchhN..............cpL-shlpphp+pLtphKcplp-lNtpRKhpQppsut+LppLEppWtpLlucsh-lEhAstpLE....tpltph+ccttp...............p	................................hss...............hhDuLPYhDpth..ssth......+pt.......sttLlppEhp.............thps.s..p.s......hhs......L..Ps.......s.s...............hs.h.p.shhppEh-.Rltsp..................pP...hthlsh..pRYc...hs...sP...ssspts...............shssWpp..slppuhsplpHtshR.hpNL.-.L...hpp.aGs.s...A..Wt...hhN................ppLpph.lpphpcpLpc.....h+..cplpplNhpRKttQ.p.suscLp.tLEppWhphVu+Nh-lEhsh.pLc.......ppl.ph+pp............tt................................	0	72	117	173
+5529	PF05701	WEMBL	DUF827;	Weak chloroplast movement under blue light	Moxon SJ	anon	Pfam-B_6516 (release 8.0)	Family	WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments [1].  Thus several member-sequences are described as "myosin heavy chain-like".	33.00	33.00	33.00	33.00	32.90	32.90	hmmbuild  -o /dev/null HMM SEED	522	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-12.94	0.70	-6.04	36	300	2012-09-25 08:00:20	2003-04-07 12:59:11	6	10	31	0	200	315	0	319.10	18	60.30	CHANGED	uAPFESVK-AVSKFG.Ghl........DWKtt..psh..ERRpt.hcpEL-psQcElschKcph-sAEssKspslpEL-pTK+llEELKhpLE+sppEcpQA+QDoELAclRs.cEhEpGluscsSss.....uKspLEsA+pRassAlsELcuVKpELcpl+c-assllsc+-sAhp+AcEAhsuuKcsE+pV--LThELlAsKEuLEpu+AAHhcAEEc+hssshu+-pDphsWcpELcQu-cELppLppcl..husp-LcuKLcpsoshLhsL+sELsuahp.uclsp.s..............p.....hp.t.lsus+cELEEsKtsl-KApsEsssL+ssusSL+uELEpEKusLssL.+p...+EuhAuhsluuLcsELp+scpElthsps+EpcsccthsE.lsppLQQAupEu-pA+ttAcsAp-Elp+sKEEAEpAKAussshEtRLpAshKElEAAKASEclAlsulcA.LpEpc.sstpsps.t....SssslTLolEEYtpLS++ucEuE-hAsp+VusAluplEtAK-oEs+oL-+Lcpsp+-h-p+KpALctAh	.........................................................................................................................................................h.tth..h..........p.th..ph..sp..httht.tlt........................................................................................................................................................................................................................................................................................................................................................................h.....-Lpthp.t.......lpphtt-...ht...htt...lpt..cl..tp.ptthtphpp....p.....t.tt..h..tlp.ch.....thttpht.h..tp.tt......................t.h...hpphtt-hpth..p.......p.ph..h.tphp..p..htthp.ph....p......t....t..hh.....................................................................................................................................................................	0	30	112	160
+5530	PF05702	Herpes_UL49_5		Herpesvirus UL49.5 envelope/tegument protein	Moxon SJ	anon	Pfam-B_7354 (release 8.0)	Family	UL49.5 protein consists of 98 amino acids with a calculated molecular mass of 10,155 Da. It contains putative signal peptide and transmembrane domains but lacks a consensus sequence for N glycosylation. UL49.5 protein is an O-glycosylated structural component of the viral envelope [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.25	0.72	-4.12	8	35	2012-10-01 21:33:21	2003-04-07 12:59:11	6	1	24	0	0	48	0	93.50	35	98.32	CHANGED	M.sS.shhphshslslssllllulspusss-...................tthsltppt...cFWcuuCSA+GVsIstuouAoVlFYluLlAVllALLuhuYpACFRLFTuShhpccW	...................................................h.hsh.hhlshhlhhuhspus.ss....................t.shh.ptt..hsFWcAuCSA+GVsIstsossoVhFYluLlAVhVAlluhAY+ACFRlhTsshhppp......................	0	0	0	0
+5531	PF05703	Auxin_canalis	DUF828;	Auxin canalisation	Moxon SJ, Eberhardt R	anon	Pfam-B_7298 (release 8.0)	Family	This domain is frequently found at the N-terminus of proteins containing Pfam:PF08458 at the C-terminus. It is a component of the auto-regulatory loop which enables auxin canalisation by recruitment of the PIN1 auxin efflux protein to the cell membrane [1].	22.80	22.80	23.50	23.00	22.00	22.70	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.73	0.70	-4.55	11	176	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	19	0	114	162	0	205.20	37	58.36	CHANGED	PpTPp-s.MEFLSRSWSlS.AoElS+ALts...................................t.t.ppshShsuspsspllh.t...............................stssusPlsPpc.ls..cssphh+ss...............................hTlG+Wh+c+ct..........K++-csRscsAplHAAVSVAuVAAAlAAVsuussss.s....................stpsuKhssAlASAupLlAo+ClEhAEthGAD+-plsoAVpSAVsl+SsGDlhTLTAAAATALRGAAsLKsRt.KEspp....AAlhPsE+ut	....................................................................s.ps.MEFLSRoWS.S.u.p.lspsh..................................................................tt......tt......hh...................................................sh...t..h.....p...h.h................................................................holu+Wh+cpct..............++K-csRhcpAplHAAVSVAulAAAlAAlsAuss.ts.........................s.tp.ss+h.shAlASAAsLlAupC.lEhAEthGAc+-plsusVpSAVss..posuDlhTLTAuAAT........uLRGAAsL+sRh.pc.h..........Ash.Ph-c.s......................	0	12	62	89
+5532	PF05704	Caps_synth		Capsular polysaccharide synthesis protein	Moxon SJ	anon	Pfam-B_7575 (release 8.0)	Family	This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae [1]. 	24.50	24.50	24.50	24.50	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.88	0.70	-5.24	28	400	2012-10-03 05:28:31	2003-04-07 12:59:11	7	9	331	0	91	614	130	240.00	21	70.01	CHANGED	+...........hh.h..tt..h.hppphhhphLccphpphl.pashppppp.pppp........IWhhWhQGh.-sA.PclV+pClpSl++pt..ssaplllLoccNlccYlslPchlhcKhcpGhl...shspaSDlLRlpLLspYGGlWlDATlaho..sslss.hh......cssFFsh....ppstppspshshupW.......................hhluu.ppsp.llshhcchhhpYa.pppsphhD..YFlhchhhpls.......hcp..ph.pphhch.h..hsNtp...ahLtthlpptascphapplppp.o.slaKLoYKhphsptpp....poaap+l	..............................................hhhh.....................................................p....p..tp..+........IWhhWh.Q.G...-sh..P.pllcp.C.hpShc+hh..ssaclll..ls.....c.....c.....N.....l.p..cY..l...s.....h..P..c..h...lh..p+h..p.pst..h.........sh..s....ah....SDllRlsLLtpYGGlWlD..uolhho...psl.sphhh..........ppshash..........pps.t....tt.......p..........h.h...p.....pa............................................hlsu..pps.s.....h.hp.hh.pch.h..h........t...aW..ppp.p.........Y.hh.h.phhh.hh.......hp.......................s.s.......h...h..p.......t.........h....t........phph....................................................................................................................................................................	0	14	42	68
+5533	PF05705	DUF829		Eukaryotic protein of unknown function (DUF829)	Moxon SJ	anon	Pfam-B_7638 (release 8.0)	Family	This family consists of several uncharacterised eukaryotic proteins.	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.43	0.70	-4.67	43	555	2012-10-03 11:45:05	2003-04-07 12:59:11	9	10	206	0	411	571	34	210.60	20	72.88	CHANGED	slll..........................lhGWh.Gups+altKYsshYpc..tGhpslhhpssshphhh.s......ptlpsshcplhphhtspptpt...............sllhHsFSssGhhhhtshh....p...hppppthtphh..lpGhl....hDSuPutsph.htshpuhuts.hsps..............................ht.hhhhhhththhhhhhhhh.pssphhppt...hpshppssht.......ssp......LalYScsDtllshc-lEpahsptcp..pGhp.VpttpacsSsHVsHh+paP..cpYhspltcah	.................................................................................llllhuWh.sup.+pltKYsph.Ypp........uhp.hlh.hpsshhphhh.t.......................................ptht.hhp...t.lhth......h..p.p.tt.....................................llhHsFSsu...Ghhhht.hhh.........................t...hp.ptp........t..p.hh..............l.....t....uhl....................hDSsP..s..ph....shtshshs....h.h.....................................................................h..hhhh.hh.hh..h.h.h....h...hh..h....h.h......s..h...h.h...tp............hp....ht........t.........................h.p......halYS..psD.lhshps...l-p.hhpttcp....................tuh....lp...a..tosHs..sH.hp..t..........p.Yhthh.ph..................................................	0	122	232	349
+5534	PF05706	CDKN3		Cyclin-dependent kinase inhibitor 3 (CDKN3)	Moxon SJ	anon	Pfam-B_5217 (release 8.0)	Family	This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner [1,2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.11	0.71	-4.80	2	187	2012-10-02 20:12:17	2003-04-07 12:59:11	7	6	136	7	85	382	124	132.60	34	62.73	CHANGED	MKPP.SIQsSEFDSSDEEPl--EQTPIpISWLsLSRVNCSQFLGLCALPGCKFKDVRRNlQKDTEELKShGIQDlFVFCTRGELSKYRVPNLLDLYQQhGIlTHHHPIsDGGTPDIuSChEIMEELsTCLKN.RKTLIHCYGGLGRSCL.AACLLLYLSDoISPpQAI	............................................................................................................................................................................Rs.lppD.hppL+.s..G...hps.l.hs.hhspsELsp.....h..p..V....s..s...L.h..c...hhpp.tG..h.....h.h..a..HhPIsDs..s..s.P..-...h....s...p...t..h....p.....l.h...p..E....L...t..t.t...Lp.......s..sp....+..sl.l..HChGGhGRo.s.L...lA.ApLLl.........l..............................	0	29	44	58
+5535	PF05707	Zot		Zonular occludens toxin (Zot)	Moxon SJ	anon	Pfam-B_3320 (release 8.0)	Family	This family consists  of bacterial and viral proteins which are very similar to the Zonular occludens toxin (Zot). Zot is elaborated by bacteriophages present in toxigenic strains of Vibrio cholerae. Zot is a single polypeptide chain of 44.8 kDa, with the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through mucosal barriers [1,2]	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.55	0.71	-4.84	17	575	2012-10-05 12:31:08	2003-04-07 12:59:11	7	5	398	2	85	1421	205	183.60	20	52.20	CHANGED	hlhllsGtsGuGKThhAVsh.lhs....slp...p....GRhlhT.NlstLs.lc......ph.p.....hp................................h....thht.W.ps....s..psullVlDEspp..hassRsh.st...........................................................shl.shapptRHhGhDllllTQshshlccplR.s.Lsphth+hp+t.shth.tpaphsh..shp.......thtphhp.......hphhphPKptFuhYc.Sss.ps	.......................................................................................l.hhpGhsGuGKo.h...s..l...h....l.......................tht..........p............s..R....l...hs...s....lp...s.lp...hp............th..t.....................................................................................................................t....p.h..h..pa...tt............................ts.u...l...ll.lDE.s..pp..h..ass.cts.....pth...........................................................................................................................................................................................sphh..ph.h....s.pH........R..H......h.......G.......h.......Dl..h..l..h....TQ.sh...s...p....l.....c.p...l.R...p....hs...c...hthch.t..p.t....h.....h.G..h.tth.hphph.......hhpt................ptht.........tthhphspthathYp.Ssp.t.......................................................................................................................................................................................................................	1	21	49	67
+5536	PF05708	DUF830		Orthopoxvirus protein of unknown function (DUF830)	Moxon SJ	anon	Pfam-B_5425 (release 8.0)	Family	This family consists of several Orthopoxvirus proteins of unknown function.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.17	0.71	-4.24	33	2265	2012-10-10 12:56:15	2003-04-07 12:59:11	7	15	1518	6	287	1396	159	163.10	23	72.02	CHANGED	plppGDllFhsss.sslsptlss.......SphsHsuIhhspss.....................s.hhVlEA.hsp.....sschssLpcFlpc......psphtVhRLpsh.....ttthppshphAhphlGpsYshsa..t.....................sc+hYCochVtcsY.pshGl.hsphphhtphhh................................sPpshhcssplptlh	..............................................................................................................hpsGDl.l.Ftp...s....t......u....sh.......sttIphh.op............u...huHluIh.ls..cs........................................................................hl..h.....Eu........hss..................sV..p..hs.s.L...p..p.ahpc...........spchs.lh.R.lssh..........s...pptpc.l.......s..p....p.......u.......p..h....l..s....p..s.....Y..s.hs..h..h.hp..........................................................................................s.sp.h.a....CSchVhcsa..tth.s...h..................h............................................................h............................................................................................................	0	118	176	241
+5537	PF05709	Sipho_tail		Phage tail protein	Moxon SJ, Bateman A	anon	Pfam-B_5084 (release 8.0) & Pfam-B_10063 (release 10.0)	Family	This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	20.30	20.30	20.30	20.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.63	0.70	-5.24	71	1621	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	917	9	143	1105	17	296.70	14	91.64	CHANGED	hhhlhshshtsss.....pshpphs.stsG..th.hhs...sphss+plslshhlhst.....shtc...........hpth.+ccltphl..tsccs.hhLhhssc........................................ss+hahshhssp...hsh...cpt..sshs.phslsFhs.spP.at.o...........h..............................................................................................................................................tspthshstsh.hh..................slhNtG...........sspspPh.....lclphp...ssssh.....hslhs.....................................................................................................................................................................................................................................................................................................................................hpsG-....pltls....ptssslhlsuhp.hhsthshs...........pphhtltsGtNp.lplps....ssshplph.pa+..hah	...................................................................................................................................................................................h......h.....s......ph.phs..shsG......th....hhs.......t.p.hp.sh.plslthhhts........sht.s................hp..h.hcclhphh.......stc....p....h....hlh..h.ps.p.......................................ss..hh.ah.s..h..h..s....ss...hsh......ppt......hs.s.......phslphhs....pP.athu................................................................................................................................................................................................................t.tph.th.s.tsh....................................................slh.N.s.G...........shp..s.tsh..........lclpht......tss.sh.....ht.lhp..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hpsuc.....hlhlc.........pppp..pl..h..h...s....s....h......hhsth..s..ht.............................p.h...tlts.G..Np.lphp.........s.hp.hph..pa..ha....................................................................................................................................................................................................................................................................................................................................................................................................	0	59	105	126
+5538	PF05710	Coiled		Coiled coil	Yeats C	anon	Yeats C	Family	This region is found in a group of Dictyostelium discoideum proteins.  It is likely to form a coiled-coil. Some of the proteins are regulated by cyclic AMP and are expressed late in development ([1]).	21.40	21.40	21.40	21.60	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.63	0.72	-3.52	10	120	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	4	0	120	121	0	84.10	32	90.54	CHANGED	MTIlASISSIGNsKSoSKSsluSFuSuo.S..hGSNSIuC....GuCGGuu...hshssssssuGlt......lGsslD..LsusssossGhsuuhhG...................us.....SCGC	.....MTlhuSISSlu...ss...p..o.sS...K.S.s.l..u..S.huuu.o.S.....uSN.SlAC........GuCGGuu...........ss...ssGhh........hsh.sh...lsss..thstuh..hss..t.........................tC.......................................	0	102	120	120
+5539	PF05711	TylF		Macrocin-O-methyltransferase (TylF)	Moxon SJ	anon	Pfam-B_5055 (release 8.0)	Domain	This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the swine industry. It is produced by several Streptomyces species. As with other macrolides, the antibiotic activity of tylosin is due to the inhibition of protein biosynthesis by a mechanism that involves the binding of tylosin to the ribosome, preventing the formation of the mRNA-aminoacyl-tRNA-ribosome complex [1]. The structure of one representative sequence from this family, NovP, shows it to be an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyses the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the mature antibiotic. It is likely that the key structural features of NovP are common to the rest of the family and include: a helical 'lid' region that gates access to the co-substrate binding pocket and an active centre that contains a 3-Asp putative metal binding site. A further conserved Asp probably acts as the general base that initiates the reaction by de-protonating the 4-OH group of the noviose unit [2].	21.10	21.10	21.10	21.10	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.66	0.70	-5.30	16	452	2012-10-10 17:06:42	2003-04-07 12:59:11	6	12	353	11	134	489	715	213.40	27	70.32	CHANGED	ssssppLYLDLl++lloNhlY-D.sh....................ssshlscssacscsRspGpDWPslAHTMlGh+RLcNLQcClEpVLtDGVPGDhlETGVWRGGACIhMRuVLtAaGlpDRsVWVADSFpGhPssssssHshDpthc.LHpaNclLuls..lEpVRpNFpRYGLLDDQVRFLPGWF+DTLPsAPl-cLAVLRLDGDLYESThDALssLYPKLSPGGaVIlDDYsl.PuCRpAVcDYRscaGIs-sIpcIDtsGVYWR+o	........................................................................................t................................................................................................................................h.t..h.t.p..sl..GshlEsGV.a+G...u...u...s...h........h...h...............t...sh...l.........t...s...h...s.........p.......s........R.......p..l..al.hDoFpG.h....Ps....s.sh....p.....p........h............t........c.....h........s..........................h........p......p.....h.....s................h.......t........s.....s...........h-p..V.....p......p...........s.....h..p...p...a.s..........h...h..s.....c......p.lc.....h.l..pGhF.p-.T....L.s....s.....s.....s.....h......c....p.......l.......All+lD....s.........D.h.YcS...Th.su.LptlY..s+..l........s...G.G.........hlll...DD.Y.....s....h...........s...s.....t....p....Al.p-...a...ht..p.ht......................................................................	0	54	98	113
+5540	PF05712	MRG		MRG	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_5530 (release 8.0)	Family	This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation [1][2].  It contains 2 chromo domains and a leucine zipper motif [3].	20.50	20.50	21.50	22.70	19.10	20.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.31	0.71	-5.41	33	687	2009-01-15 18:05:59	2003-04-07 12:59:11	8	14	280	9	443	658	7	206.40	31	57.75	CHANGED	ssst.cusc+ppst............p.th....hpcspl...plplPspLKphLVDDWEhlTKpp..+lltLPs.phsVspILccahpp......h...p.ppspsss..........p.p.............................hlcElls..Gl+hYFspsLu..phLLY+hER.QYtplhppp........................................................................................................................................................................sshs.SplYGA.HLLRLhlp...LPphlutos.hDppolshLhpplpphlpalspp...pchFsppsY	......................................................................................................................................t.p.sppp............t..........ppcth...........hpc.pl...plplP-pLK.hLV..D.DW-hls+pp............pLh..tL.Ps....p.hsVssIL-cYhph...............hp...ppsssss................t.....................................................hlp.Ells..G...l+...pYFshhLs..s.LLY+..aERsQYt.clhtpp................................................................................................................................................................................................................................................................................................................................................................shs.SplYGA.HL....LRLF............V+...lsthL....uho......s....hspc.sl..t.......hLhp.hlp.pFL....paLscpt..sphFstp..................................................................	2	114	174	307
+5541	PF05713	MobC		Bacterial mobilisation protein (MobC)	Moxon SJ	anon	Pfam-B_2832 (release 8.0)	Family	This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region [1]. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localised DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA [2]. 	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.45	0.72	-3.99	27	1793	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	994	0	198	1402	105	47.80	25	39.04	CHANGED	ll.......ppLutlGsNlNQIA+phNs.....thss.cph.h.httLh.plpppLpplpc	........................hpLsplGsNlNQIA+phNp.........tth..ttt..ph..................l..tl.t.......h........................................	0	71	131	175
+5542	PF05714	Borrelia_lipo_1	Borrelia_lipo; 	Borrelia burgdorferi virulent strain associated lipoprotein	Moxon SJ	anon	Pfam-B_7866 (release 8.0)	Family	This family consists of several virulent strain associated lipoproteins from the Lyme disease spirochete Borrelia burgdorferi.	20.80	20.80	20.80	20.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.37	0.70	-5.23	18	520	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	34	4	27	422	1	182.80	25	78.06	CHANGED	ppppscchKNsLLsD..........L+NLIEpAsp-+-KYhK+hcEEPs-Q....YGIhu..FcpL.Wstu.spEslu-s.oc+ShpYR+hsYus.LNslcss.cLKchocIlh.........hutpsptlaNlhpplGtslDpllspLYsKKDsLsKL-Is.cLc+LKNshEKlLSlKphlScMlsQLLLDYpssps.I+TDssKLcsals.pl.pQh.cKpcEu-pLKspIhoI.tsl	..................................................pp.pp...p.h.hsp...........pp....h.c.s...t.....pchcp.h.h.K.....p.h.....c.tp..ppp......................h.thtt.......hchlth.........h................h-.h..tts.....pphph++hhYos.L.s.appp.clpphtpIlp..............t..thh....t.thlh....p.h....h.....hsl..php.....l-phlt.hl...p..p..p.Ds..L.p.php.p.plcpLhpph-p.LplKpphtctlp..phl.-......Ypp..N..p...stI+s...-.pt...Ltp.ahp...............p....tp..th..........h..................................	0	17	17	17
+5543	PF05715	zf-piccolo	Zf_piccolo; 	Piccolo Zn-finger	Yeats C	anon	Yeats C	Domain	This (predicted) Zinc finger is found in the  bassoon and piccolo proteins (e.g. Swiss:Q9JKS6). There are eight conserved cysteines, suggesting  that it coordinates two zinc ligands.	30.00	30.00	30.10	33.90	29.00	29.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.50	0.72	-3.96	12	212	2012-10-03 17:27:21	2003-04-07 12:59:11	8	9	36	0	101	168	0	59.80	62	3.12	CHANGED	s+shCPLCpTp...luo.s.sNFNTCTpC+spVCNLCGFNPsPHLTElpEWLCLNCQhQRAL	......s.pshCPLCpTp....lu.o.p.-.s....PNaNTCTpC+spVCNLCGFNP.sPHLo.E.h.pEWLCLNCQhQRAL........	0	4	17	41
+5544	PF05716	AKAP_110		A-kinase anchor protein 110 kDa (AKAP 110)	Moxon SJ	anon	Pfam-B_5702 (release 8.0)	Family	This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction [1].	25.00	25.00	26.70	25.90	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	685	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.55	0.70	-13.31	0.70	-6.54	5	156	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	35	0	76	141	0	335.10	35	35.52	CHANGED	oP+KSLSKIASELVNETVoACS+NhssDKAPGSGDRs.uo.QS.PsL+apSTLKIKESsKcGpGPDsRPGSKKSFFYKEVFESRNuGDA+EGGR.hPt-RKhFRs.-RPDDFosSIScGIMTYANSVVSDMMVSIMKTLKIQVKDTTI.ATIVLKKVLLKHAKEVVSDLIDSFMKNLHNVTGoLMTDTDFVSAVKRolFSHGSQKATDIMDAML+KLYSVlhAKK.PEplRKscDKSESYSLlSMKuGsGDPKsRN..LNFAoMKSEsKlREKspocs.ssKEcTCAETLGEHIIKEGLTlWHpoQQNpsKSsuhptu.....ppQhtss.-hshthP.D.sphs..tsPpsPEKsENFMs-SDSWAKDLIVSALLLIQYHLAQ.............................GGspDA+SFlEAAuoTNhsPssSPss+DEu+L+Ss.l.hs-.EpsEKKDLpSVlFNLIRNLLSETIFKs-csCEuKs+cp.lKE-+uspCERPl.......Sssss+hsED-E.TsGAlSGLTKMsssplDGpMNGQMVDHLM-SVMKLCLIIAKSCD..AuLAELGD-KSGDASR.oSAFP-NLYECLssKGTGoA.EAlLQNAYQAIHNEhRuhSuQPPEGCthPcVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAsAVEKGpSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMuNL	........................................................................t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..llV.N.s.psph..tpLpAsLQWlAASphslPhlYFhtsp-s.hEK..........h.plsthstcKuapVG-lhptVhpatK...c..p.pt..tp.sphp.LhDWLh..........................	0	4	8	28
+5545	PF05717	TnpB_IS66	Transposase_34;	IS66 Orf2 like protein	Moxon SJ	anon	Pfam-B_5707 (release 8.0)	Family	This protein is found in insertion sequences related to IS66.  The function of these proteins is uncertain, but they are probably essential for transposition [2].	22.10	22.10	22.30	22.30	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.29	0.72	-4.62	135	3276	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	1155	0	503	2167	362	95.80	41	89.63	CHANGED	sss+laLsstssDhR+GhsGLuslVppslth-PauGslFlFps+..RtD+lKlLaWDusGhsLhhKRL..EcG.+Fh.W.P..sspt..slpLos..tQLphLLcGlDhppsp.t..sh	.......................s..pla.lssuhsDMRpGhsGLuthVppsh.p...-P.a.S.G.p.lF.lFp.G+..+tcplK.lLahDus.G.hs.LhhKR.L..E..p.G..+Fh......W..P...sscps...hhtLo...tQlsh........LlcGlshpt.t.....hh..............................	0	117	266	386
+5546	PF05718	Pox_int_trans		Poxvirus intermediate transcription factor	Moxon SJ	anon	Pfam-B_5843 (release 8.0)	Family	This family consists of several highly related Poxvirus sequences which are thought to be intermediate transcription factors.	21.40	21.40	22.30	25.20	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.39	0.70	-5.94	12	61	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	44	0	375.30	68	99.35	CHANGED	MccLFpaL+sIEDcYsRTIFNFHlh+ss-lusIYshh+-+IuspshFsclV.sscl+psIKKLlYCDIplTKHIINpssYsshssssppss..KhuQaFDIphssss..hStRTs-IF-pDKSSLlSYIKTTNKKpKlDYGEIKKTlHutspo..sYFSG++SD-YLSTTV+sspspPWIKoISKRhRlDIhspuIlT+GKSSILQTIEIlasNRTCVKIFKDSThHlILSKDKsEpuClsllsKLFpsYclLFtLlaslTtsptFtphtssuscllssssF-EKlshI+pht..c.YGlpNFKlGMFNLTastsIsaTVFPSLLct.sSKIKFFKGKKLNIVALpSLc-CtpYVp.ApslLctMpcRSphLsslsItosSV-pLKpLLh	....................MDsLFoFLH.EIED+YuRTIFNFHLISsDEI.GDIYGlMKERISuEshFDNIVhscDI+sAIK.KLVYCDIpLTK.HIINpssYPlaNcoups....KpspaFDINoDsus..ISpR.TVEIFEREKSSLVSYIKTTNKKRKVsYGEIK.KTVH..GGTsu..NYFSGKKSDEYLSTTVRSshsQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKcE+GClchIDKLFhVYhsLFlLhcDIhpN-hFcEVAslss+VLouTshDEKLhlIK+hA..DsYGVsNFKIGMFNLTFIKul-HTVFPSLLD-.-SKIKFFKGKKLNIVALRSLEDClpYVocSEshl-hM+ERSsILNuIDIETtSVD+LK-LL.l...............	1	0	0	0
+5547	PF05719	GPP34		Golgi phosphoprotein 3 (GPP34)	Moxon SJ	anon	Pfam-B_7957 (release 8.0)	Family	This family consists of several eukaryotic GPP34 like proteins. GPP34 localises to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking [1].	23.00	23.00	23.80	23.30	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.53	0.71	-4.25	88	612	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	392	9	331	621	2	216.50	28	82.18	CHANGED	Ls--lhLLuhcsp.pGp....hhssshphu..LsuuhLhELsltGclpls..........ps+......l.tsh..sspsss......................-s..lLcps....lptlt......ptc.spp.....spsWlpt.ps............+sh.pctl...tpp...Lssc.Gllcpccp..phLshh...hh...pas.hsD...sstcpplpp+lpssl....sttss............................................sscsss.......LlsLhtus.slhpphh.ss...............................ppscptlpp...........lsptshhst.........................................................slcpt......lpphpsAs	......................................LhEEl.LLL.uLc-c...pGhh...hhsssluhu..LpGshL....l....ELuhcGRlplp...................pc+........................l..hlh.ssssTG......................-s..lLD-uLchl+............spt..s.o.........lpsWI.chhsG..............+sl.R-+l.scs....LV-+.GlLps.E+p....sh.L.h.h..shssaP..ls-...ss.h+pclhc+lpssl.....p.ssts.................................................shRshu.......LlsL.AaAu..sllcssh..ssh..p...c........................ppscphltp..........h.p.hs.............................................................................tht.................................................................................	0	118	192	272
+5548	PF05720	Dicty_CAD		Cell-cell adhesion domain	Yeats C	anon	Yeats C	Family	This family is based on a group of Dictyostelium discoideum proteins that are essential in early development ([1]). Swiss:P16642 and  Swiss:P16643 are located on the cell surface and mediate cell-cell adhesion.	19.00	19.00	20.50	19.10	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.52	0.72	-4.34	6	17	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	4	0	16	20	1	76.10	30	37.11	CHANGED	IhN--GESTISGKuaPLPsPhIaPsPYhhRFhcYchEGpLWsNcEFclKSGKIEasGEEaDIPpSpsshhKh.D-ptshI.l	...........l.sptGcSoIpGhshshPs.h.aPsPahhph.h.p..YphEG.s.l.asppcFclpSuKlEhsGc.ca-lPsSpssh.c..-p......................	0	15	16	16
+5549	PF05721	PhyH		Phytanoyl-CoA dioxygenase (PhyH)	Moxon SJ	anon	Pfam-B_5670 (release 8.0)	Family	This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterised by the accumulation of phytanic acid in plasma and tissues [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.38	0.70	-4.30	39	3239	2012-10-10 13:59:34	2003-04-07 12:59:11	8	56	1181	23	1723	3267	6124	205.00	16	65.62	CHANGED	accsGalllcs....hlss.pplsthppphppl.............................tthtsstphphhhptpttsststhh.....ts.pthtthhcs.............hhsshscphlspssh.................htshh....hh+tsphGsss...shHpDhthh........ttP....tphls....hhlAl-Dhsh-NGshhhlPGSHph..t....hh...th.tt.............................tpthlsh.hctG-sllacsplhHuotsNpost...Rpu	.................................................................................................................................................................................................pppGalllps....hhs...pph.t.t.h.p....p...t.h.t.p.h..............................................................................h.....t.t........t...h.....t...h...h..h.t....t...t....h.....h.t.....t.....t.hh....................t...hh.th.hhps.................................thhshh.pplhstphh....................................................h.pshh..........hh.p...s.t....Gsts............sh.H..........p...........D...h.t.h..h...............................hps..............phls...........hhl.sl.s..-.s...s.......c..s...G..........s...........hh..h..........l.....P...G.....S......H..p....h........h.................h..t.tth.tt........................................................................t..t..t....h.h....h..t..h....ps.Gsslhapsp.hh.H..s..u.s..tN..tott...R.....................................................................	0	633	1084	1476
+5550	PF05722	Ustilago_mating		Ustilago B locus mating-type protein	Moxon SJ	anon	Pfam-B_5804 (release 8.0)	Family	This family consists of several Ustilago mating-type proteins. The b locus of the phytopathogenic fungus Ustilago maydis encodes a multiallelic recognition function that controls the ability of the fungus to form a dikaryon and complete the sexual stage of the life cycle. The b locus has at least 25 alleles and any combination of two different alleles, brought together by mating between haploid cells, allows the fungus to cause disease and undergo sexual development within the plant [1]. 	25.00	25.00	37.50	35.50	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.85	0.70	-5.10	2	41	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	6	0	1	40	0	123.50	69	42.78	CHANGED	Il+KFARpDRsRMKhLVpAKh.uSs.Ss.s.uTpsSLssNLDDlLp-NLG+.LTPsDKppFEDDWsSMISWIKYGVKEKVGDWVYDLsAAsKKo.P+sG.sRsVTTsApRpPARKTtstspsKs+pAp.RASpTPShDST...StLESTPELShCSTADsSFSoFsSshShupasPFQp..pl.QSPolpsRGsRKVKALPKRAupp.PsE...lsN....................................................GpIPFl.........sLSsAFs	....ILKKFAREDRSRMK+LVRAKLSSSNQSoPPS.................................................................................................................................................................................................................................................................................s..........	0	1	1	1
+5552	PF05724	TPMT		Thiopurine S-methyltransferase (TPMT)	Moxon SJ	anon	Pfam-B_5821 (release 8.0)	Family	This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines [1]. 	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.50	0.70	-4.90	12	1046	2012-10-10 17:06:42	2003-04-07 12:59:11	6	7	838	11	423	2913	640	189.50	24	87.81	CHANGED	hstshWpppWtssphsacQppsssLLh+ahss..ps.sshRsLVPhCGpuhDhhWhAspt+.VlGl-lS-hAlpchhp-ts.....pPp..hpphssh+c.............DhFshpsppl..hDhlaDRushsAlsPchRspYupphhpLL.ssuc..hhLlTLpYs.scts.GPPF.Vst.....tEhctlhs.sshcltplcp.tDsLss..chtt.slpthtEplahl.p+p	.........................................................................................thWp.pp...a...t...p...s...p.....h...s...a...c......t....p..........s.......s.....s....h......L...h....p....a.......h...............p...........p.....................t...........................t..........t................t.....t......c....lLl.P........h.CGc.u..h..D..h..h..a.L....A..s...p...G...........a..p.V.hGl-l..S..p..h..A..l...p...p...h...h...p.cp.th..................p.p.....ht..p..h......s......s..h...pt...................t....t..l...p..h..h..t.u..Da....F......s.......h...s..........s....t......t......h......t.....t.....h..chl.a.D..p.s...h....h....s..A..L......s.........p.....h.....R....t.....p.......Y..s......ppht....pl..ltssup.............h.L..l.....s........h.....t...a.......s........t.....s....p.......h...t.....G...P..P...a.s.l.s..t............t-l.pth...hs....h...h...p.l....h.................................t..................................................................................................................................	0	151	249	342
+5553	PF05725	FNIP		FNIP Repeat	Yeats C	anon	Yeats C	Repeat	This repeat is approximately 22 residues long and is only found in Dictyostelium discoideum. It appears to be related to Pfam:PF00560 (personal obs:C Yeats). The alignment consists of two tandem repeats. It is termed the FNIP repeat after the pattern of conserved residues.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.03	0.72	-4.00	34	6356	2012-10-02 21:32:02	2003-04-07 12:59:11	7	134	22	0	5165	6328	244	42.60	32	40.91	CHANGED	FN.Qs.lphsslP.............................pulppLph.ussFsp.lp..hssLPpSlppLphupp	..............................................................aN..p....l..t.......s...s...l....P...................................................................s..o..l......p...pL.pF.....G....p.......p....F....N...Q....s..lp.............s...s....l...P..s...S..lp.p.Lphu...................	0	2305	5161	5165
+5554	PF05726	Pirin_C		Pirin C-terminal cupin domain	Yeats C	anon	Yeats C	Domain	This region is found the C-terminal half of the Pirin protein.	21.30	21.30	21.30	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.24	0.72	-3.95	34	2522	2012-10-10 13:59:34	2003-04-07 12:59:11	8	12	1617	3	1004	2315	1370	103.60	28	34.49	CHANGED	alDlpLpsGuchphs.hspsapshlYll...pGs.s...........plsupp.........lstpplslhu...sGsplhlpus...pss+....hlLluGcPlsEPlhhaGPFVMsop-EIcpAhp-acpG..+Fs	................................................................hDlplp.s.Gu.p..hsls....h.s...p....s....a.....p.shlYll...cGs..l.........................................pl..supp.......................lp.ss..p.hslhs.............sGs.p...l...p...l.p....As.............psuc..............llLl..u.G..c..Pl.sEPls.ha..GPFV.Msoc-EIppAhpDapsG.ch...........................	0	307	618	837
+5555	PF05727	UPF0228		Uncharacterised protein family (UPF0228)	Bateman A	anon	SWISS-PROT	Family	This small family of proteins is currently restricted Methanosarcina species.  Members of this family are about 200 residues in length, except for Swiss:Q8TMK1 that has two copies of this region.  Although the function of this region is unknown the pattern of conservation suggests that this may be an enzyme, including multiple conserved aspartate and glutamate residues (Bateman A. pers. obs.). The most conserved motif in these proteins is NEL/MEXNE/D, where X can be any amino acid, which is found at the C-terminus of these proteins.	25.00	25.00	30.80	29.90	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.83	0.71	-4.39	13	26	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	5	0	26	25	0	120.50	39	64.74	CHANGED	MThNYoI-Ysoshhst+YYIhlDKDch.DltcE.LpK-......csWT.s....sI+KGDYYlIsVSEQAIcDcsFLslLcK.NlQVKKhVaChIpF..sDGS.......+s.WIPEcDAlRIKNELEpNEsVhoVthDYlhs	.................hshNYsI-YNsshhsscYYIhVDcDch.slhpE...LpKs......csWh.s........lKKGcY.YlI.lSEpslpDcsF............LslLcKpsLQlKKhVhChIpF..ucGo.......cs.hIsEcDAl+IKNELEpNEpllhVth-.l..s........	0	9	13	13
+5556	PF05728	UPF0227		Uncharacterised protein family (UPF0227)	Bateman A	anon	SWISS-PROT	Family	Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes that are distantly related to the Pfam:PF00561.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.98	0.71	-4.57	9	1870	2012-10-03 11:45:05	2003-04-07 12:59:11	7	4	1161	0	305	1448	549	179.10	38	93.88	CHANGED	hllYLHGFsS.SPtsHct.l.hpahspcshhlshss.p.tcp.pphlpclcphltphsscp...shlsGsuLGGYaAphlu.hpGl+p..VlhNPsltPhcshsshlsc............Epa+.hphKslpsht.............hcp.s+hhllhu+tDElLD...pcssuchpshhphVh-ss.sHtFpshucalpplhuFts	............................................................................llYL.HGF...sS..SP..........t......s.........t....c..........t.....s..l....h....h......p...a........lst...c.h................l........p...h.............s............p........................................p....c...h.........h....c..............l.........-.....p....h......l....t.....p...p......s.s..cp................hllGsSLGG...YaA.......p.h....l....u..........h.....h.......s.....l...tt..........V..l....l.............N...P..u...l..p...P...a......E......h...p....s...h........l..s...p....................................................................................E.......p..h..p......h..s.....h....K..s.....h.ph.......................................................cs.....D.phhllhppsD......E......l......LD.......pps...s...t.....h.....h.....t.....s.....h.....h.....p.........h.....V...h....-ss..sH.tF...p..s.hp.s...ahp.p.IhsFh.s..............................................................................................................................................................	0	55	142	229
+5557	PF05729	NACHT		NACHT domain	Bateman A	anon	[1]	Domain	This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation [1]. This family is closely related to Pfam:PF00931.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.90	0.71	-4.59	26	5874	2012-10-05 12:31:09	2003-04-07 12:59:11	7	749	661	0	4173	9193	904	159.70	19	16.53	CHANGED	cslllpGpAG.GKTsLhpplshtWApuph.p......hphlFahss+phspts.......uLs-lltsphspsssshsc..............h...lhphspRlL..............hllDGhDElts..s...........p.t...hLLtsLlpcplLspsplllTsRssuhtp...ltptlpps...............hhpltuFspsptpphh.pcaassp	.....................................................................................hlhlpG.sGhGKo.s....l....s.........p.........p.........h..........h.........h.........p..........h........s........p........s......p........................pt................h..th.....h.....a...h...h..s...h..p....p...h..s..t......p.t.......................sl.t.p....h..l......h.....p........t......h....s....p....h....t....t......h.tp............................................................................h...h.....p.....p...............t.....p.....l..l....................................................................h..l.l..D.G...l..DE...hp...t..p......................................................................h...h..l...t..........p...l.......l........p......t..................h....s.....p....s........p......l....h.......l...o.......o...R..s..t...t..h..............h..t.....h....................................h.l.........h............t...............t...................................................................................................................................................................	0	1337	2441	3535
+5558	PF05730	CFEM		CFEM domain	Bateman A	anon	[1]	Domain	This fungal specific cysteine rich domain is found in some proteins with proposed roles in fungal pathogenesis [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.52	0.72	-4.15	114	969	2009-01-15 18:05:59	2003-04-07 12:59:11	6	17	154	0	757	948	0	66.30	25	23.45	CHANGED	thsslPsCAhsChsp.sh......ss..Cs...hsDhs....ChC...stsshtsslssC.....lt..ssC.s.ss.......ps..............ssh....................shss.shCu	..................t..stlPsC.u......h..s.Chtp.sh....s......ss...Cs........hsDhs........Cl..C........sps....s....ht...s......s...ltsC.......lt.....ss..Cs..sp.......-t...........................ssh....................shsp.shCs............................	0	152	421	636
+5559	PF05731	TROVE		TROVE domain	Bateman A	anon	Bateman A	Domain	This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs.  This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding. 	21.30	21.30	28.20	28.00	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.09	0.70	-5.70	9	567	2009-01-15 18:05:59	2003-04-07 12:59:11	6	42	303	6	249	524	40	237.30	18	39.07	CHANGED	lpsspGshsapssspscltp........h....LshuspssoaYtstpc.spsphpcll+tltpt-sphllphhhhhppctphtchsshlhAlAlhtp.s.....+...................tshchhscVs+hPocLhphlpa..................ph..tsspptsshs+slR+ulschasphs....thtLsKY...c.pRsuhph+DlhRhsH.cssss................thsthhpahhct........................h.h...h.pphhptpssptlphLpua.......p.....t.hpchhh........................................shE+.los+ls............stpVWcsLlps..hPhhAhLRNLsslscsGV.spsps....hVhpRLsctctlc+SRhaPachLsAhcshspucup.+sp..............................................................hpW.ss.plhp....ALEpAhthu.hcNlsPhss	.......................................................h...................................................................h..hht..h.......p.s..h..hp....h.hpt.t..h...h.p...hhhs...hh............................t...................................................................hh..hh.thhp.sp.hhthhth................................................................................................................hst..pthh.phh.p.h.....t.thhph.......p..tt.t.p.tc.....p..t.......................................................hh......h.........................................................................................................................................................................................................................................................Wttlh.p...hsh.th.hhpLtph.t.s..h..t....................lhthltp...t........lhpuh.hPhphh.A.p.h..t........................................................................................................................................................lt.uh.hs....h..............................................................................................................................................................................................	0	97	149	203
+5560	PF05732	RepL		Firmicute plasmid replication protein (RepL)	Moxon SJ	anon	Pfam-B_5929 (release 8.0)	Family	This family consists of Firmicute RepL proteins which are involved in plasmid replication.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.05	0.71	-5.03	4	349	2012-10-04 14:01:12	2003-04-07 12:59:11	6	2	297	0	26	301	50	118.70	27	83.06	CHANGED	hppRhtshhpGoEpaINpsoGElhEhphlhhcppshNFsKsalppllphLDLlGNpKs+ls.allcNLN.psNslItTsRclAccTGhSLpTVppThKhLp-uNhlK+ps.GVhhlNP-lLh+Gscpc+h.lLlpFpph-pEspchp.........................................EsuLhpht.hK	.....................................................................................................................................................................h.-..l......l..G.....p..K.....c......h..cllp.a..lh..-.s...h-...ps....s.........h....l.....h.....h...s...h.s......-..l......p...cc..l.....s......h..S.+.sT.lhpshKhLc-pp.ll...p.....+.h......p...........p...........G......h.........Yh...lN........................................................................................................ht..................................................	1	7	19	23
+5561	PF05733	Tenui_N	Tenuivirus_N;	Tenuivirus/Phlebovirus nucleocapsid protein	Moxon SJ, Bateman A	anon	Pfam-B_5998 (release 8.0) & Pfam-B_19756 (release 10.0)	Family	This family consists of several Tenuivirus and Phlebovirus nucleocapsid proteins [1,2]. These are ssRNA viruses.	25.00	25.00	25.10	26.50	18.10	24.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.34	0.70	-5.07	12	395	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	94	10	3	299	0	203.80	40	85.00	CHANGED	-hpchh.chuspAlc.....csplhsalsphsYpGaDAt+ll.pl..Lpc+u...Gcsat+DlphhIVhphTRG.....sh.cKh...hsstGucpsppLls+Yslhp..Gssu.DsITLuRlAuhFsshohpslpslo..s+LsVsuoshssh.uhsh.hh.hhPpFhsL.ssohP....cshtphlhshHhLahh.ho+ph.ssh+tcp+s.....-llchhsp.hshshsup.lsspc....R+clltsFtl	..................phpchhs-hupptls.....hs-l.sastphtYtGaDstplI.tl...LK-pG.........G-shsK.DhphhIlhthsRG.....shhpKh...hsstGuppstsLls+YGlhpp..Gss.uhssITLuRlApshs.shoppssttlp..thhsVsusshshh.ups.shh.hhPpFhtL.s.ohs....cuhs+hLhssH.la.hphoKph.s.ch+ttp+s.....-hhp.hpt.hhhsspSt.h.pcp....++.h...h......................	0	3	3	3
+5562	PF05734	DUF832		Herpesvirus protein of unknown function (DUF832)	Moxon SJ	anon	Pfam-B_7683 (release 8.0)	Family	This family consists of several herpesvirus proteins of unknown function.	18.80	18.80	21.90	72.40	16.90	16.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.36	0.70	-5.15	13	32	2009-09-11 10:40:49	2003-04-07 12:59:11	6	1	24	0	0	29	0	222.20	27	50.08	CHANGED	MphslPVhGlspppp....pcWppllssFtscsssspsls.L++hFc.......tcschuhLuSLllLhphltsspptpp+ts.Llpsh.ts+hlApplacclhspps.pps.h-phFt-C+sRLtLLLEpsCGChpChpsscuLpcsp.thhR.P+LpPHpppstutshLsplaNpslLssssslscapltsLh.sscphsshs.chpsEsshlusClhhCWLaalLppalps-lpslcpsl	..hp.slslhhlspcpp....ppapplhssFts..psssspslt.l+phap........pschuhLuuLlhLhphl.sstphtp+.s.Ll.shptshalspplah+lhspps.tps.hcphatcstsRLthllEpuCGC.pChpssctLpphp.thhcPP+lpPHpcpC.utshLstlhppslLssshslStasls-Lh.ssppa.thsssh...phEhshlsoCL.hCWlahllhcalpp-hthLcpsl.	0	0	0	0
+5563	PF05735	TSP_C	TSPC;	Thrombospondin C-terminal region	Bateman A	anon	Pfam-B_1875 (release 8.0)	Family	This region is found at the C-terminus of thrombospondin  and related proteins.	25.00	25.00	25.40	26.50	18.50	23.90	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.24	0.71	-4.75	10	444	2009-01-15 18:05:59	2003-04-07 12:59:11	7	85	95	6	222	377	2	188.30	65	21.57	CHANGED	QsDPsWVVhspGsEIhQslNSDPGLAVGccsasuVDF-GTFFIsssoDDDYlGFlFuYQssu+FYlVMWKKusQoYWpspPFcAsApsGlpLKlVcSsTGPGptLRNALW+TGsTssQV+LLW+DPhslGWKc+TAYRWpLpHRPsI.GhIRlphY-Gs+LlhDSGNIaDsTl+GGRLGVFCFSQEpIIWSNLpY+CNDsl.P	.................QIDPNWVVh.sQGhElVQTh.N...S.D.PGLA.VGa................stFsuV.DFpGTFaV.....N..T.s..p...DDDYAGFlFGYQ......s......S......SpFYVVMWKQ....s.pQTYWpssPhRAhu.sG.lp.....LKs.VpSs..TGPG..EaLR.NALW.HTGsTss.....QVRhLW..+.D.P.+Nl..GWKDhTuYRWpLpH.RPps.GaI..R....VhhY.EGpplhAD..SGslhDp..T..htGG.RLGlFsFSQE.lhaSsL+YcCp-..............................................................................................	0	43	61	129
+5564	PF05736	OprF	OprF_membrane; 	OprF membrane domain	Bateman A	anon	Pfam-B_4079 (release 8.0)	Domain	This domain represents the presumed membrane spanning region of the OprF proteins. This region is involved in channel formation and is thought to form an 8-stranded beta-barrel [3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.14	0.71	-4.76	4	245	2012-10-03 17:14:37	2003-04-07 12:59:11	6	2	226	0	16	668	18	163.40	62	55.34	CHANGED	MKLKNTLGhAIGSLlAATSFGALAQGQGAVEhEsFhKKpasDSV+phcs.G...GuSlGYFLTDDVpLsLoYDcsppsRusDsTGspKltGspouLcA.YHFGssG.DuLRPYVpuGhuHQSlsNl.ssGpsGRsQSThAssGAGsKaYFT-NhYARAGVEApYsLDpGch....-auAhVGlGVNFGGuu	......................................................................................TLGlsI.G.o.llAA....T..ShG..A..LA......Q...G.....Q.....G..A...V..E.hE....h....F...h....K..K.....a...D.....S...s.....+.....s........h.....c........s........G..........Gu...u.lGY.....FLTD....D....V..pL..t..L......u.....Y.s..c....s....H....s...s.......R...u.........D....s........s..t....s....p.....p.....I....K..G..s.s...T.....uL....DA..h..YH......F.ss......P.G...DsLRP.Y..VS.A..G.....F..u......a.....Q..S..l.......s....................ps....u.....+........s..G.....R...........D...p....S..T..F..........A......N.......l.......G....u..GsK.aY.FT-NFY..ARAGV.....E.A.pY..N...I.DpGcs...........E.W.uP..uVGlGVNFGGu.u....................................................................................	0	2	4	11
+5565	PF05737	Collagen_bind		Collagen binding domain	Bateman A	anon	Pfam-B_5000 (release 8.0)	Domain	The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices [1]. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.	20.80	20.80	20.80	20.90	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.58	0.71	-3.99	15	1660	2012-10-02 17:35:21	2003-04-07 12:59:11	7	115	482	8	145	1485	0	134.50	19	22.34	CHANGED	ssshaKpGhhDsssss...l+WplslNtshpsl..csAslpDhlssGQsLshsSlclhchshptstpssths............ptssstshtpsssssFplshss...slssuhpIsYpTpIT-tstp......papNpA.....pLssssl-shpss	.............................t...h.Kh.G....hs.....spssp.....lpWp.lslN.......t..s..pppl....pss.slsD.s......h.s......s........s........p.......p....l....s..............s...S.l..p.......l.....hp.s..s.....hsts..t.sh.s.....ht....................s..t...t.hs...s.t.s.s.s.s.....s.a.s.lpatp...........thspuahlpYpT..pl...s...st...s..p................ph.pNpu......ph..st.p........s...........................................................................................	1	80	110	128
+5566	PF05738	Cna_B		Cna protein B-type domain	Bateman A	anon	Pfam-B_366 (release 8.0)	Family	This domain is found in Staphylococcus aureus collagen-binding surface protein.  However, this region does not mediate collagen binding, the Pfam:PF05737 region carries out that function. The structure of the repetitive B-region has been solved [1] and forms a beta sandwich structure.  It is thought that this region forms a stalk in Staphylococcus aureus collagen-binding protein that presents the ligand binding domain away from the bacterial cell surface.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.39	0.72	-4.21	135	13573	2012-10-02 19:08:27	2003-04-07 12:59:11	8	388	1204	80	1267	12494	454	73.40	23	22.10	CHANGED	lpGsphpLhspssssht.......................hsTsssGphphssL......ssGs.YpltEsp.sPsGYphsssshthsht.spt.......ttlp	..........................................................................................ltGspa..pl..h...s..p...s...s.ph.htp..............................................................................hs.T.....s...p..s.....G.....p.....h..p...h...s.....s..L..............................tsG..p...Yplp..E.....s......p...u....P.....s.........G..Y.p.h...s...p...s.s.h...t.h.phtttt..........thh...............................................	0	652	998	1144
+5567	PF05739	SNARE		SNARE domain	Moxon SJ	anon	Pfam-B_6285 (release 8.0)	Family	Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex [1].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.79	0.72	-4.28	105	4036	2012-10-03 05:55:03	2003-04-07 12:59:11	14	51	377	62	2609	3820	24	61.80	22	22.43	CHANGED	cpccslpplppslt-Lcplhh-lus.lcpQschlDcI-ssl-pspsplcpuppc..l..pcshphpp	...................ppcpplpplppsltcLpplhh-lup.l..c.p.Qs.c......h.l..Dc.........I-psl-pspsplcpuppc..l...p+shp.................	0	824	1372	2046
+5569	PF05741	zf-nanos	Nanos; 	Nanos RNA binding domain	Moxon SJ	anon	Pfam-B_5908 (release 8.0)	Family	This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localised determinant of posterior pattern. Nanos RNA is localised to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localised source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback [1]. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded  very early in development. The localised and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development [2]. 	21.30	21.30	21.40	23.40	20.90	18.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.26	0.72	-3.99	36	305	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	133	4	168	260	18	55.30	54	25.74	CHANGED	CsFC+N.............NGEspplYpSHtL...............KDtcG+...VhCPlL.RsYsCPlCGAsGDpA....HTlKYCPhs	....CsFC+p...............NGEuctlYsSHtL...............Ks...cGp...VhCPlL.Rp.Y.sCPlCGAo.G-pA....HTlKYCPh.t...	0	34	47	129
+5570	PF05742	NRDE	DUF833;	NRDE protein	Moxon SJ, Eberhardt R	anon	Pfam-B_6481 (release 8.0)	Family	In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [1]. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit [2]. Swiss:P54797 has been found to be expressed during early embryogenesis in mice [3]. This protein contains a conserved NRDE motif.	20.70	20.70	20.80	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.92	0.70	-5.09	12	889	2010-07-12 16:41:27	2003-04-07 12:59:11	7	4	729	0	464	881	260	231.70	27	87.70	CHANGED	MCllhhtapsps....pacLllAuNRDEaasRPoh.ht.Wt.sss.plLuGhDlcp.......uGTWlGlspcG...+huslsNlpps.cp..st..hSRGtLV.s-aLsu.ssss...tpahcpLt...ppupcasG......FNLlhs-hp............clphhoNpsst..h...tLssGhashSNu..cssW.Ksptu+phhtchlt..pssp...ptl.hppLhplhssp...........thhsDspl.ppus.h.php+..h..Louhalc....stpYGTRusTllhVcpcu.csphhERphtspss..........hppschph	............................................................MCllhh...thpsps............th.LllhuNRDEa.....hpR.P..o.t...s..h........t.h.W...............t.......s..............s..............s....p.......l..luGp.Dhps.............GGTWlGl.s..p.p..G.................+hAsLTN..............hp..p......s....t....t...........................s...s................t.SR.GtLl.t.....pa.....L.......p......u....s.ss......................pa.h.pplt.........t.p..s...p.t.....Y..s..G..............................FNLlhu-hp............................t...hhh.....hs.....s.p.st.........t...............................................................l......s.............sG.........h.a..........s..lSN.uh................h.........s.....s.....s........W....Kh.h.t............tpthhtph.lt.............tt..tt........................pthh..thht.sp..........................................................hss....t..t.l.....pp.uh.......thtp...............h.u.s..hh.....lt.................t...YGT.Rspohlh...lp.tp......t....ph.hhEt...h........................h...........................................................................................................................................	1	145	263	376
+5571	PF05743	UEV	Tsg101; 	UEV domain	Moxon SJ, Bateman A	anon	Pfam-B_6022 (release 8.0)	Domain	This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer [1]. This family is related to the ubiquitin conjugating enzymes.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.49	0.71	-4.43	23	474	2012-10-02 15:28:41	2003-04-07 12:59:11	8	17	278	17	281	627	11	113.90	38	28.07	CHANGED	shc-lhsllptap....sLpspscsasa.sDGpsppLLsLpGTIPlpapGss.YNlPlhlWl.csYPh......ssPlsalcPTssM......sI+hsc.aVDspGcl.aLPYLppWsh...sSs.....LlsLlpphts....sFsccsPl	..........................................................hpchhphht.a.....sLp.h.hc..sasa..scGp..sp..Lls..LsG.T.I.PV.ac.Gss...YsIPl..slWl.csYPh...........................sPP.ls.a.V.p...PTssM........hI+...suc...aVDs....s.G.+l...YlPYL..p..p..Wpp..........spSs..............LlsLlphhhs....hFuc-PPl.................................................	0	94	152	221
+5572	PF05744	Benyvirus_P25		Benyvirus P25/P26 protein	Moxon SJ	anon	Pfam-B_6153 (release 8.0)	Family	This family consists of P25 and P26 proteins from the beet necrotic yellow vein viruses.	25.00	25.00	29.20	133.60	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.62	0.70	-5.03	3	211	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	182	0	213.60	72	99.80	CHANGED	DlDphMPVFDlAY.DssHtPYll+RosHEVVhsVussGFICYPL.V..DLNDssslsshlYHN+lKTMRLpVsIpNNcusassFRAhsRFlVFSTPslSsWVNNGCpSLFSPFVGVNSsIDcpLL+RDS+GloVLaDRVY+VsRaT-hF.sVDFThNFRGPGNYsLsNusNaPsATTsDSIYVACVssWlsNsVFRLpSDSVuWVHSGLapGPVL-FGQsL.sAPDcD.DGVsDDG	....MGDILGAVYDLG.....HRPYLARRTVYEDRLILSTHGNICRAI....NLLTHDNRToLVYHNNTKRIRFRGLLCAhHsPYCGFRALCRVMLCSLPRLCDIPINGSRDFVADPTRLDSSVNELLV...SNGLVIHYDRVHcVPlHTDGFEVVDFTTVFRGPGNFLLPNATNFPRPTTTDQVYMVCLVNTV.NCVLRFESELTVWVHSGLYsGDVLDVDNNVIQAP....DGVDDs.....	0	0	0	0
+5573	PF05745	CRPA		Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)	Moxon SJ	anon	Pfam-B_6389 (release 8.0)	Family	This family consists of several Chlamydia 15 kDa cysteine-rich outer membrane proteins which are associated with differentiation of reticulate bodies (RBs) into elementary bodies (EBs) [1].	23.60	23.60	144.20	143.90	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.94	0.71	-4.41	5	37	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	35	0	4	18	0	131.10	62	84.93	CHANGED	MS........ststsu..psllslVpshsup.ulspslpsposslTLlN.llGWs+h+hlpPlRsSKIlpSRAFQITLlVLGIlLVIAGLALhFlLpuQLGsNAFaL.lIPAlIGLVKLLlTSLsM.EcsCTPEKW+LCK+lLtToEDILDDGplNNSNKIF	.....................M...........STVPVVQGAGSS.NSAQDISsposPLTLKp..............RISNLLSSTAFKVGLVVlGLLLVIA..sLlFLVSAASFVNAIYL.uIPAIlGCVNICVGILSM.EGaCSPERWhLCKKlLKTSEDIIDDGQINNSNKVF...	0	1	1	3
+5574	PF05746	DALR_1	tRNA-synt_1d_C; 	DALR anticodon binding domain	Bateman A	anon	Pfam-B_196 (release 8.0)	Domain	This all alpha helical domain is the anticodon binding domain in Arginyl and glycyl tRNA synthetase. This domain is known as the DALR domain after characteristic  conserved amino acids [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.55	0.71	-4.14	104	7484	2012-10-02 19:03:26	2003-04-07 12:59:11	10	22	4857	7	2023	5803	2941	115.90	26	19.29	CHANGED	lQYAaARlpSlh+...+uspth.phttst.hh..............pc.pEhpLhtpLhpFscslppuscp...........hpPchlspYLhcLAstFspFY...p........ps....lls............scpp.h...........puRLtLspsstpsLcpuLpLLGlps.-+M	.......................................................hpYAasRlpuIl+..........Kus..t..p..h......t.h...t.s..ss.hh................................pcs..pEhpL.h.ppltp..asc..hlp..ssspp................................tpPpt...lspY..Lh.c.Lussas.pFY..s...............ps..........hlls......................p-.s..p..t....................psRLs...Lhptstpslp..puh.t.h.l...Glp.s.ppM...................................	0	661	1256	1662
+5576	PF05748	Rubella_E1		Rubella membrane glycoprotein E1	Moxon SJ	anon	Pfam-B_6726 (release 8.0)	Family	Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus.  The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds [1].	25.00	25.00	89.80	89.70	18.90	16.00	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.81	0.70	-5.89	2	838	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	11	0	0	460	0	312.50	94	88.37	CHANGED	LTAVVLQGYNPPAYGEEAFTYLCTAPGCATQsPVPVRLAGVRFESKIVDGGCFAPWDLEATGACICEIPTDVSCEGLGAWVPAAPCARIWNGTQRACThWAVNAYSSGGYAQLASYFNPGGSYYKQYHPTAC-VEPAFGHSDAACWGFPTDTVMSVFALASYVQHPcKTVRVKFHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQSRWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTVRPVALPRsLAPPRNVRVTGCYQCGTPALVEGLAPGGGNCHLTVNGEDlGAhPPGKFVTAALLNTPPPYQVSCGGESDRAoARVIDPAAQSFTGVVYGTHTTAVSETRQTWAEWAAAHWWQLTLGAICAL.LAGLLACCAKCLYYLRGAIAPR	..............................................................................................................................................................................FHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQSRWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTV.RPVsLPRALAPPRNVRVTGCYQCGTPA.LV...EGLAPGGGNCHLTVNGEDVGAFPPGKFVTAALLNTPPPYQVSCGGE..................................................................................	0	0	0	0
+5577	PF05749	Rubella_E2		Rubella membrane glycoprotein E2	Moxon SJ	anon	Pfam-B_6726 (release 8.0)	Family	Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus.  The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins [1].	19.30	19.30	19.40	594.70	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-12.04	0.70	-5.15	3	68	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	10	0	0	85	0	267.00	97	26.88	CHANGED	GLQPRADMAAPPsPPQPPRAHGQHYGHHHHQLPFLGHDGHHGGTLRVGQHHRNASDVLPGHWLQGGWGCYNLSDWHQGTHVCHTKHMDFWCVEHDRPPPATPTPLTTAANSTTAATPATAPAPCHAGLNDSCGGFLSGCGPMRLRHGADTRCGRLICGLSTTAQYPPTRFGCAMRWGLPPWELVVLTARPEDGWTCRGVPAHPGTRCPELVSPMGRATCSPASALWLATANALSLDHALAAFVLLVPWVLIFMVCRRACRRRGAAAA	GLQPRADMAAPPsPPQPPRAHGQHYGHHHHQLPFLGHDGHHGGTLRVGQHHRNASDVLPGHWLQGGWGCYNLSDWHQGTHVCHTKHMDFWCVEHDRPPPATPTPLTTAANoTTAATPATAPAPCHAGLNDSCGGFLSGCGPMRLRHGADTRCGRLICGLSTTAQYPPTRFGCAMRWGLPPWELVVLTARPEDGWTCRGVPAHPGTRCPELVSPMGRATCSPASALWLATANALSLDHALAAhVLLVPWVLIFMVCRRACRRRGAAAA	2	0	0	0
+5578	PF05750	Rubella_Capsid		Rubella capsid protein	Moxon SJ	anon	Pfam-B_6726 (release 8.0)	Family	Rubella virus is an enveloped positive-strand RNA virus of the family Togaviridae. Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly,  the capsid interacts with genomic RNA to form nucleocapsids. It has been discovered that capsid phosphorylation serves to negatively regulate binding of viral genomic RNA. This may delay the initiation of nucleocapsid assembly until sufficient amounts of virus glycoproteins accumulate at the budding site and/or prevent non-specific binding to cellular RNA when levels of genomic RNA are low. It follows that at a late stage in replication, the capsid may undergo dephosphorylation before nucleocapsid assembly occurs [1].	25.00	25.00	25.20	25.20	17.10	16.40	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-12.05	0.70	-5.02	3	110	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	10	0	0	117	0	208.20	97	34.49	CHANGED	MASTTPITMEDLQKALEAQSRALRAELAAGASQSRRPRPPRQRDSSTSGDDSGRDSGGPRRRRGNRGRGQRKDWSRAPPPPEERQESRSQTPAPKPSRAPPQQPQPPRMQTGRGGSAPRPELGPPTNPFQAAVARGLRPPLHDPDTEAPTEACVTSWLWSEGEGAVFYRVDLHFTNLGTPPLDEDGRWDPALMYNPCGPEPPAHVVRAYNQPAGDVRGVWGKGERTYAEQDFRVGGTRWHRLLRMPVRGLDGDSAPLPPHTTERIETRSARHPWRIRFGAPQAFLAGLLLAAVAVGTARA	MASTTPITMEDLQKALEAQSRALRAELAAGASQSRRPRPPRQRDSSTSGDDSGRDSGGPRRRRGNRGRGQRRDWSRAPPPPEERQESRSQTPAPKPSRAPPQQPQP...................................................................................................................................................................................................	0	0	0	0
+5579	PF05751	FixH		FixH	Moxon SJ	anon	Pfam-B_6803 (release 8.0)	Family	This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalysed by FixG [1].	21.90	21.90	22.40	22.20	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.71	0.71	-4.38	118	910	2012-10-01 19:30:51	2003-04-07 12:59:11	6	3	891	0	266	726	75	141.60	21	86.55	CHANGED	+phhsa....hllshhusllssslshhhhAhsshs.uLVs-shYctupshstpl.....sctcttpsLGhp.splphss..........splplpl...tpGtP.htstplshplh+PTpsppDh.shhls...tsssG..hYpu...h.....hpGpWplcl................pssspta+hptclh	.......................thasa.......hllhhh..hsllhsslshl.h...lA.h..p.s.....s...slVs...-sY....Y.cpu.pshs.t.ph.....sph.p.t..tp.p.hshp..sp.l.phps..............................sthplph....tpu.....ts......sp..tlp.lhhh+P...sp.....tp.....pD.......h...pl.lp........tsG.......haps.shpt...........hpG.pW.lcl................p..t.st.ah......h..........................................	0	74	168	218
+5580	PF05752	Calici_MSP	Calicivirus_MSP; 	Calicivirus minor structural protein	Moxon SJ	anon	Pfam-B_6811 (release 8.0)	Family	This family consists of minor structural proteins largely from human calicivirus isolates. Human calicivirus causes gastroenteritis [1]. The function of this family is unknown.	21.20	21.20	21.20	72.00	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.07	0.71	-4.65	14	126	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	121	0	0	88	0	165.00	49	99.90	CHANGED	MSWhsGALtsuGSLVDhAGTISsIVhQQRQls.h....pcQNcl.pcWhs+QEsLQcct.-lo+-LulpGPstRVpuAlsAGFsslsARRLAGSsERVhYGhLDRPIhptushpu.IppT+HLpshpuALosFKpGTs.aGpPsPPphthspPt.pssssplNL.GasPsSSsl	..........MSWLVGALQssGuLVDhAGTVSsIVYQpRQls.L....cpQNpLhpsWMsKQEtLQ+ctM-Loc-LulNGPAhRVpuAl-AGFDsVSARRLAGSuERVIaGhLDpPIhptsshsu.lppTpHLsslsuuLuTFKpGTs.FGp.PsP....Pp.h.psGsPt....pss.sP.plNl.GapPGSSss........	0	0	0	0
+5581	PF05753	TRAP_beta		Translocon-associated protein beta (TRAPB)	Moxon SJ	anon	Pfam-B_6857 (release 8.0)	Family	This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion [1].	21.60	21.60	21.60	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.08	0.71	-5.12	22	254	2012-10-03 16:25:20	2003-04-07 12:59:11	9	7	174	0	139	284	8	166.30	32	74.51	CHANGED	hh.hh.lhhhhs.shupp-s........sARlLspKplLscahVpsc-lsVpYsIaNlGsusAhcVplsD.suF.stcsFplVuG..phosph-plsPsssloHshllcP+p.GhFshouApVoY.....+ssccssphQhuho..ot.upssIlup+shs+pFost....hh-WhuFushshsshsl.....PhhlaasSKspYpth.pK	..............................hh....h.hhhl.hh.h.shsps-p............sAtllspKpl.Ls+.hhVtuc-lslpaslYNhGsu.sAh-Vpl.sD...sua....s......s-sF.......pl.Vu...G..........hshph.-.RlsP..u..u.sl....oH.shVlc.P.pp.hGhFshosAploY......hsppp.....st.l.t.huho........os.sthsIls.+th.s++Fs.t............hhcahshsshsh.shhh.....shhlh..SKpphtt....tt...................................................................	0	45	68	105
+5582	PF05754	DUF834		Domain of unknown function (DUF834)	Bateman A	anon	Pfam-B_9258 (release 8.0)	Domain	This short presumed domain is found in a large number of hypothetical plant proteins. The domain is quite rich in conserved glycine residues.\	 It occurs in some putative transposons but currently has no known function.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.25	0.72	-4.17	18	515	2009-01-15 18:05:59	2003-04-07 12:59:11	9	34	5	0	411	501	0	64.80	32	26.11	CHANGED	psssssshpsTspsscpssuscpsGuss.RlDsDsGAPsVsGpstGADElscssA+shssss.ocuDstssG	........................................t...........s.sttptstscp..uG..GusR..l.Ds...ssGsPAV...s..spstusDclstssAcPptsss.p....p...tcs.tuss....................	0	0	0	12
+5583	PF05755	REF		Rubber elongation factor protein (REF)	Moxon SJ	anon	Pfam-B_6903 (release 8.0)	Family	This family consists of the highly related rubber elongation factor (REF), small rubber particle protein (SRPP) and stress-related protein (SRP) sequences. REF and SRPP are released from the rubber particle membrane into the cytosol during osmotic lysis of the sedimentable organelles (lutoids). The exact function of this family is unknown [1]. 	25.00	25.00	26.50	26.30	22.20	21.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.33	0.70	-4.59	10	99	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	31	0	41	94	0	182.90	39	85.39	CHANGED	-pspsEEc+...LKYL-FVQsAAlYslssFSsLYtaAKDpSGPLKPGV-sVEusVKsVVuPVYpKFasVPh-lLKFlD+KV-soVp-LDR+VPPlVKpASuQAhohh..hs.hs.tlAsEVppsGlhtsAp.......shspshhs+......tLhspYEPhAEphAVpsW+tLNpLPLhPpVAplslPTAAahSEKYNcsVshsu-+GYsVAsYLPLlPTE+IuKVFtc-s	..................................t...ptpptc...LKaLtFVphAuhpshh....thuslYtaAKcpu.GPL.+sGVpsVEssV+sVluPVYp+FcslP.-lLtFlD+KVD-slpc....lDc+lPs.....hlKpssspAhshhptss.............s.tlsuEsppsGshtssp......................................lhscaEs.hA.tp.hulpsWptLNphPhhPpVsphslPsAAahoEKYNpslhshsc+GYthstYLPllPhEcIu+sFt...t.................	0	4	29	35
+5584	PF05756	S-antigen		S-antigen protein	Bateman A	anon	Pfam-B_7194 (release 8.0)	Family	S-antigens are heat stable proteins that are found in the blood of individuals infected with malaria [1].	25.00	25.00	92.00	91.90	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.27	0.72	-4.01	4	57	2009-09-15 09:48:53	2003-04-07 12:59:11	6	1	6	0	1	58	0	62.60	79	62.61	CHANGED	MNRILSVoFYLFFlYLYIYKTYGKVKNTDcELSNIYGsKYYLRsGhhNpKNGKGpKYEDLpEEtEGENDDEEDSNSEESsNDEENtLIEGQspu	.......VoFYLFFlYLYIYKTYGKVKNTDpELSNIYGTKYYLRsGhFNcKNGKGpKYEDLEEE..................................	0	1	1	1
+5585	PF05757	PsbQ		Oxygen evolving enhancer protein 3 (PsbQ)	Moxon SJ	anon	Pfam-B_6905 (release 8.0)	Family	This family consists of the plant specific oxygen evolving enhancer protein 3 (PsbQ). Photosystem II (PSII)1 is a pigment-protein complex, which consists of at least 25 different protein subunits, at present denoted PsbA-Z according to the genes that encode them. PsbQ plays an important role in the lumenal oxygen-evolving activity of PSII from higher plants and green algae [1]. 	25.30	25.30	25.30	25.50	24.90	25.20	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.07	0.71	-4.90	18	175	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	69	5	82	172	2	161.80	26	81.35	CHANGED	phsssusspssstRusls....lRAst.........t.t..pssRRAllG.LlAsulsuuuhspAshAs.........sh.htlshssP.sushsGs.spspARDhpLs.lKcR......FaltsLuPs..EAAtRsKcSAp-I.lsl+shI-+Ks..WsaVpspLRL+uuY..LRaDLsTllSuKP.c-cKpsLh-Ls.scLFpsl-sLDaAs+pKsss-ApKaYtcThssLs-VLApLu	..............................................................................................ht.................................................................................................................ts+sh.....t.t......hh...hsst..tshtRh+psApcl.hslcs..h....I...-ccs...WshlpptLRh+uua..L+hDLpsl....Isu.p.P.c..cc.+pslpcLs.scLFsslscLDhAs..+pKssspspphYtpshpsLs-lluhh...........................................................	0	20	52	70
+5586	PF05758	Ycf1		Ycf1	Bateman A	anon	Pfam-B_6040 (release 8.0)	Family	The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. Although the function of Ycf1 is unknown, it is known to be an essential gene [1].	29.20	29.20	29.40	29.40	28.40	29.10	hmmbuild  -o /dev/null HMM SEED	929	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.64	0.70	-13.90	0.70	-6.83	44	1439	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	1082	0	33	1491	2	450.30	52	62.57	CHANGED	SVVlVGLYYGFLTTFSIGPSYLFLLRAplh..........EEGTEKc.............lSATT.GFIsGQLhhFISIYYuPLHLALGRPHTITVLsLPYLLF+..FFasN.pK...cFh..sasp...sspNSh...RNhsIQslFLNNLIF.QLhNhhILPSShLsRLVNIYhFRCNNKhLFVTSSFlGWLIGHILFhKWlt.....LlLhWIc.........p.NpS.................Icp...........Ipss......KY..LVscltN.h...+I.....................................................................FSILLFIoClaYLGRhPs.PlhTKKL..pp...............................................schcct........ccppphch-p..ct.....ttscpcpchs.tpps......lh..ccpts.pp.........................................................................................................................p.hp.......pp........phhhF.cKPllTlLFDYcRWNRPhRYI...K.Ns+F-..ssV...RsEhSQYFFtTCpSDGKpRISFTYPPSLSTFh-MI.p++ls.....lhshcK.h...s--.....LYsp...WlhoNcpK+ssLssEFlNRIcsLD+u.....lh........................h-lLEp..RoRL..C..sscscpc.........hLsKh.....................YDPhLNGsaRGp...............I..cchhSss...............................l......hsc...s.hcs.hcphh.....lN+laslLh............sssapchEpc......s..........hcslspph...h..........l.p.s.p...............................................................................................................................................t.p....l........tph.........pppppphhphlhshlhss..pppph.p....cs...................................ltI.pEIp......KKVPRW...SYKLhs-......lEptct-...cp...sst-ppIRSRKsK.+V....llhss.......pp...tp.................................................................................................................................................................................pcptc..-...hslhRY.SQQSDFRRclIKGSMRAQRRKslIWchFQsslHSPL.......FLD+h-Kh...hhF.sF..slsphhc........................hla+..........sa..hp.Kppchch.s...pccphpc.............Kppc.ph.....pcpcRlp.IAEtWDsl.hAQhlRGhlLlsQShLRKYIlLPsLIIuKNIuRlLLFQhPEWsEDac-WsREhHlKCTYNGlpLSEs....EFPcsWLpDGIQIKILFPFpLKPWHcSKhp.........................t.p...hpcpt.c+c................................................................sF..CFLTVWGhET-lPF.GsP+KpP....SFFcPIh	......................................................................................................................................SVVVVGLYYGFLTT..FSIGPSYLFLLRA+VM..........EEGTEKc.............VSATT.GFIsGQLMMFISIYYAPLHLALGRPHTITVLsLPYLLFH..hF....hNN....pp.....p.hh.............s.GS............TT.RNSM..........RNL.SI...QCV.......FLNNLIF.QLFNH.F.I.LPSSsLARLVNIYMFRC.NNphLFlTSSFVGW.LIGHIL...F.MK.WhG.......LV.LhWIc.........pNs........................................IcSN........................................................KY..LVSELR.NsMs..RI...................................................................................FS..ILLFlTC.VYYLG..Rh.PS.PlhTKKL...KEs..........................................................................................................................................SchEEh.............ctcpcsc..lEss..Eh.......ctspp-.pct...tpp.........................t..........pp........h..............................................................................................................................................................................hp.t...p.p.cs....ch.thhcp...................ph.h.a...h.....-K....sh.lThhFsacRWNRPhRYI....t............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	26	30
+5588	PF05760	IER		Immediate early response protein (IER)	Moxon SJ	anon	Pfam-B_6450 (release 8.0)	Family	This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it  play an important role in mediating the cellular response to mitogenic signals [1,2]. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals [3,4].	21.70	21.70	27.70	23.40	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.20	0.70	-4.49	10	171	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	48	0	78	166	0	176.10	27	97.89	CHANGED	MEstl-AQpllSISLtKIaNSRsQRGGIKLHKNLLVShVLRsARQlYLS-+YutlYhttpttpstsssspp........................................................................................susstlpPPSutt........................................lsspspSP-....sss-P....u.hpsssucs.ssust..sssssGs.psspsosLDhsocVlTTVEsuhLpp............................................sCss..p.u.t.t.spsssspRKhpsuuhtS-uucss...........uhsPs.KRuRhE-.sspshu-sp-up.........puNloNLISIFGSuFSGLLS+pssusps...hstp..........hCsKpALusLusWoRAIVAF	...........................................................hth-ApplhslSlhKhhpSRhQRGGl+LH+sL.lohVhRsARp......l......Yhst........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	10	18	33
+5589	PF05761	5_nucleotid	5_nucleotidase; 	5' nucleotidase family	Bateman A	anon	Pfam-B_2948 (release 8.0)	Family	This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.	27.00	27.00	27.40	27.30	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.40	0.70	-5.97	21	680	2012-10-03 04:19:28	2003-04-07 12:59:11	9	8	168	12	393	595	21	368.90	30	81.95	CHANGED	lFsNRsLsLcsIchaGFDMDYTLAhYps.phEpLuF-hsh-+Lls.hGYPpslh.phpYDPpFslRGLhhDptpGNLlKlDtaGplt..ssaHGhc.Lss-Elt-hYssp.plphcpst..........pathlsTLFuLPEssLhAslV-ahp......................................sss.hphsappLacDV+cAlDpVHhcGpLKpclhpclp+Ylh+DsclshhLp+L+psGKKLFLlTNSsasYsDthMsYlhst..s..........sWRshFDlVIVsAcKPtFFs-sp.PhRplDscsGpLphsp................hssLc+G.........plYpGGsh.phpclhGh+.GsclLYlGDHIauDlhcoKKppGWRTshll.ELccElclhsscptthsp..LppLpslhsclpsphs...................................ctsshpt.slpphppchcplppshcphFN..aGuLF+s.GsppohFupQlpRYADlYsoplsNhLpYssthhF+us+s..hhPHEsss.ps	...................................lasspphphpplp...hhGFDhDYTLs.Yp..th.ctLhaphshchLl.p..htYP.pp..lh..p..h.p...a.-.s.s..Fs.h.R...GL...hhDh.hG.LlKlDt.at.l....hsh+G.h.p.l........tt.p.......-l.hchYssp..hl...ht.t.p..................phh..h.slFslP.EhhLhupll-hht..............................................................................p...t...p..h..h.s.....hphapD...V..p...s......Al......p...s....H.......h.......p..........G.............hh.......p.......t.......h.......h.......ps.p....+Yl...p.s.s.p.h...hhLpc........hpp.t.G.t.......p..lFLlTN.Ssapass..thMpa.....h.hs..................sWpshFDlllspAp...........KP.....tFFs...c...tp...sh+pl.s......pp..u.t....h...t....hs.p.................................................h.t...lp..pG................tlY...pt......G...sh.....t....h....h....c....l.............h........s.....h...c......G....p.....c......l..LY.hGDHlauDl..hpsph.t..puWRThhl..l.ELt..p..Elphhtppp...h.t...httLp...htph......................................................................................................................................p.tt....htt..h.tphp.h....t.h.p..as...hG.hh+s...p.ohF..pl.+auslYhuph.shh...a...hhahs........h.Hc.....s........................................................................	0	140	203	293
+5590	PF05762	VWA_CoxE	vwa_CoxE; 	VWA domain containing CoxE-like protein	Bateman A	anon	Pfam-B_2956 (release 8.0)	Family	This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain.  The exact function of this family is unknown.  It is found as part of a CO oxidising (Cox) system operon is several bacteria [1].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.30	0.70	-5.21	17	2445	2012-10-10 16:07:06	2003-04-07 12:59:11	9	3	1560	0	642	2460	867	184.40	23	42.62	CHANGED	Ltctltt....hhhthstcR...ph.spt+st+lDh++TlRtslpputp..........hthhh+p..Rppcs.clVlLlDlSGSMptaoshahtlhpAlhtsht..cschFsFuTplsclTptl.pttDsspuLhcs..p..h...huGGTcIupuLtphtphhstps...tusVlllSD.....uh-psshstLtpplscLppput+llhLsPh..tthsuacsp.stulcAhhspV.sthtPscphpsl	................................................................................h.................h..h.....t..h..........t..tphDh..p..tTl..p.....t..s.h...t..p..hh...................................h.h...tp........+..p...s....p...s........p.lll..hlDsSG.SM.........s...........s...........a..........s.........t.......h..........t.......h......t.......l....h..p.....u.......s.....h..s...p.hp..........+s.cl.h..h...F.s....T...p......l.......s.......c..........h..........p.........t......h.......s.....................s..........p..h...l......h.hh.........p..........ht.......G.G.............T....c.......lu....p.sh.t....h....h..h......p..h...h......t....t..........t...............p...s...s.....h..lllSD........h.h..t..t....t............s....h...h...p...p...l.t.c...h....p.....t.+..hhh....hss.......thsth.................................h...........................................................................................................	0	197	410	528
+5591	PF05763	DUF835		Protein of unknown function (DUF835)	Bateman A	anon	Pfam-B_3039 (release 8.0)	Family	The members of this archaebacterial protein family are around 250-300 amino acid residues in length. The function of these proteins is not known.	28.10	28.10	28.80	37.30	26.90	28.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.79	0.71	-4.61	38	148	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	24	0	116	168	35	135.30	25	39.06	CHANGED	G.uhhhsspp......hhthlcsh.p....sslsloRp...sPcpact.........lhWlT+sp...uc..s.....ulsPTpLthlh-hlhcalcp..tss....lVllDsLEYLlL.NGFculhKFLtsLKDhslhpsut.lIlhsc.cuhs-+-hslLc+Ehp	..............................p.....hh.hlpp.h.pth...ssLsloRp...sPcphp........th.hlWlopsp...sc....p........slsPopLt.hlhch.lhcalcp.ttps.....lVllDslEYLll.NG....FcslhKFLtsL+Dhs.lhpsuh.lllsl-.pslsc+phslLpRph........................	0	19	27	73
+5592	PF05764	YL1		YL1 nuclear protein	Bateman A	anon	Pfam-B_3088 (release 8.0)	Family	The proteins in this family are designated YL1 [1]. These proteins have been shown to be DNA-binding and may be a transcription factor [1].	29.00	29.00	32.00	29.70	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.92	0.70	-4.76	37	325	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	271	0	234	329	1	213.70	27	44.43	CHANGED	htsRs+RusAGp+hppLLptE.-t--...pp...................hFpE---DpEaptppp-ppp................................................................Dsshsssp.s-...........cssss--t-uE+t.....ptcc..+++hhtpcthhc.hh...........h+h+h..............................phps.sssc.c.....tpppc.p.h.ohhss........tRpSsRpoThpppptsht+Lp-p-t+Rtph.t......t+++tptpp+thTQEE+LtEAccTEchNh+SLp+acchEtpKKc......pshpp+ph.pGPhlpahSst	................................................................sRspRssAGp+hpp.LLptE.c.p..D-h..t..t............................hFp.E..-..ps...D.c-aptppp-p-s..............................................Ds-hsps-.s-.............psssss-t-tc+...........................++.+..hhh.ppth..htsht............h+hph......................................................t.pt.tt.t.p............t.p..p.tp........h.s.ht..........................tRpShRposh...p.pt.th..+.h...pcppt.....pc..ht.......................tp+ct..t....tppc.hTQEEhLtEA.t..TEchNhcSL...ppapch.Etc+Kc........pshtp+t..h.tGPhlpahSh.s.............................................................................	0	76	128	195
+5594	PF05766	NinG		Bacteriophage Lambda NinG protein	Moxon SJ	anon	Pfam-B_7000 (release 8.0)	Family	NinG or Rap is involved in recombination. Rap (recombination adept with plasmid) increases lambda-by-plasmid recombination catalysed by Escherichia coli's RecBCD pathway [1].	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.48	0.71	-4.55	19	590	2012-10-05 18:28:12	2003-04-07 12:59:11	7	4	389	0	37	440	99	170.90	48	96.91	CHANGED	h..+ps+.+KCK..sCsshFsP.tpshQ.pVCSscCu......hthtp.....tppccpc+ptpptERpcl+tRKc+LK..s+u-ah+-sQtshNcalR.hRDh..shPCISC.......Gp...........hpsupacAGHYRosGAsspLRFp..NlHpQCshCNpahS.....GNlls..YRhsLlc+IGhEcVEhLE.usHpspKasI-EL+plpshY+uKh+cLc+......cuA	..........................................tp..cR+CK...CtphFhP.hht....sQ.hh...C.s..ppu............hth.tc.........ttpttcc..cp+...ppcpcp+c..ch+h+Kh...slK..s+u.hWl.+.p.AQpAhNtaIR..pR.....Dt.........s..hs....CISC.......Gs...........hp.u.up..aDAGHYRosuAsP....pLRFsEpNlHpQCs.sC.Np+.KS.......GNlVs...YR..lp..LIs...R...IGp...EAV-plE.....uNHst+RWTlEE..h+uIKucYppKLKcL+p.....uct........................................	0	3	14	26
+5595	PF05767	Pox_A14		Poxvirus virion envelope protein A14	Moxon SJ	anon	Pfam-B_7009 (release 8.0)	Family	This family consists of several Poxvirus virion envelope protein A14 like sequences. A14 is a component of the virion membrane and has been found to be an H1 phosphatase substrate in vivo and in vitro. A14 is hyperphosphorylated on serine residues in the absence of H1 expression [1].	25.00	25.00	25.00	25.80	23.60	23.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.19	0.72	-4.03	9	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	1	25	0	89.70	60	99.01	CHANGED	MDhhthlpNhaSslllsGIlLLhsACIFAFl-FSKsspss-.sWRALSllsFIlGhllllGhllaohYsRaCt...sosshcssRh.Nso-IELs	..MDhMhhIuNYFS.GVLIuGIILLllSCIFAFIDFSKsT.u.P.Tc.TW+sLSIhuFILGIlITlGMLIYSMWG++CsP..sSsVIcs.....NpSDIplN..............	0	0	0	0
+5596	PF05768	DUF836		Glutaredoxin-like domain (DUF836)	Moxon SJ, Bateman A	anon	Pfam-B_7010 (release 8.0) & Pfam-B_2829 (release 14.0)	Domain	These proteins are related to the Pfam:PF00462 family.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-10.03	0.72	-3.72	48	1303	2012-10-03 14:45:55	2003-04-07 12:59:11	9	7	1259	7	450	2272	1309	77.50	25	77.65	CHANGED	plhLau+ssCsLC-.......thpphLpt...hthptt.........hplphlDIs.....ssss..Lhp......................+Ys.clPVlthss............................tthhphtlst-pLtphLp	...............lhLa.s+t.sC.tLC-.......pspph.Lpt......l.t..t.chs.....................hplph.l...DIs.........psss........Lhp.........................cYs...........c...l.P.V.lhhss.............................tphhha.hctppLpt.l.h....................................................	0	104	261	371
+5597	PF05769	DUF837		Protein of unknown function (DUF837)	Moxon SJ	anon	Pfam-B_7035 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function. One of the family members (Swiss:O02197) is a circulating cathodic antigen (CCA) found in Schistosoma mansoni (Blood fluke) [1].	21.30	21.30	21.40	21.30	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.23	0.71	-4.75	9	231	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	103	0	133	212	1	152.70	36	73.36	CHANGED	MosTl-plLhDAKslspRL+-+Dshu-sLl-potslp+pVcuM+........pYQE-hp.lpclu+.+sp....hhlpQENpQI+-LQQEN+EL+soLEEHQpALELIMuKYREphhphhhspKhs.sEhhhp...hpcphsp.lpsQh-+IsEMusVM+cAlplD-pphspppEplspLchENctLR-lLpIS+p	....................................................................shohpphlhDA+tLhpRL+-p-stu-sLlppstslpppl.t......uh+......................papE-h.p.p.l.pchuc...+sc.........hhlppE..Npp.l....c-LQpEN+...........ELphuLEEHQpALELIMsKYR....c...phh....plh.hsp+..h...t...s.t.hht..........h.p.....pp....p...sp.lptp....hc.pIpE....MutVMppAhp...hD-pp...t.p..pphl..pL.p.ENptLRchLtIsp...................................................	1	38	46	78
+5598	PF05770	Ins134_P3_kin		Inositol 1, 3, 4-trisphosphate 5/6-kinase	Moxon SJ	anon	Pfam-B_7042 (release 8.0)	Family	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1].	20.20	20.20	20.20	21.70	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.04	0.70	-5.41	5	297	2012-10-10 13:17:03	2003-04-07 12:59:11	6	6	113	8	186	306	8	257.30	33	79.58	CHANGED	usshp+RhlVGYALosKKlKSFlQPuLluLARpRGI-lVslD.oRPLsEQGPFDlIIHKLhD............cEW+cpL-EFR-AHP-VsVLDPPcAIc+LHNRpSMLQlVu-Lcl...uscscRlGlPcQlVlhpD.uuulsculspAGL+FPLIAKPLVADGTAKSHEMSLlYcQEGLptLcPPLVLQEFVNHGGVLFKVYVVGEsl+VV+RhSLPDVSpccL..ssucGsFsFspVSsssuou-......-sEl..Dh..ulAEhPPcslLc-LA+ALRRuLGL+LFNFDlIR-spstDRYhVIDINYFPGYuKMPuYEsVLTDFlho	........................................................................................................................hhh..t+.tph.....th....s........ttp.sh...hl.ls...phslt..pQ..G..s.h.DlllHKlh.s..........................................................thh.pthp..cahp.t..HPps.hl.lDP..uIpp.........LhsR.p.hphl.t.c....lph...............t......tt.......p.....l.t.......s.P...h.....lp.....p.......s.......t......sh.....p.h...lt......ps..........uLphPh.lsKshV...Ac...Go.p..SHcMullas........p.cu.L.........p...t........l......p.....s.........P....h...........V..lQ.pFlNHsullaKVaVlG-ph.ps.VpR.SL....s..hs..t.t..p........sp.t..t....h.hh....p....tp.....l.Sp.ts..ss...........................tth....-............t..........hp.h..P...s.t....t....h.....l.....pp.....luptLRptLGlp.LFs.hDlI........h...............pt..t........s.............s..........p.a.hlIDlNhFP...G.............atthsta.t.hhphh..p.........................................	0	71	119	151
+5599	PF05771	Pox_A31		Poxvirus A31 protein	Moxon SJ	anon	Pfam-B_7044 (release 8.0)	Family	\N	22.40	22.40	23.20	66.00	20.80	19.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.49	0.71	-4.28	6	59	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	30	0	0	49	0	112.70	75	84.00	CHANGED	M.-IFphL+.hE+phFsshslslPKcKpshsaKshsFIFYpPKcsplp+YlssuslaHoDhlVhGKVlIsshKhLLhYMDLpYYGlohsGshY+LGpSIccLSLcppKlhs+hot	Ms.SILNTLRFLEKTSFYNCNDSITKEKI.KIKHKGMSFVFYKPKHSTVVKYLSGGGIYHDDLVVLGKVTINDLKMMLFYMDLSYHGVTSSGsIYKLGSSIDRLSL.NRTIVTKVN.N......	0	0	0	0
+5600	PF05772	NinB		NinB protein	Bateman A	anon	Pfam-B_4884 (release 8.0)	Family	The ninR region of phage lambda contains two recombination genes, orf (ninB) and rap (ninG), that have roles when the RecF and RecBCD recombination pathways of E. coli, respectively, operate on phage lambda.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.49	0.71	-4.49	13	563	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	435	2	37	310	28	118.00	46	85.64	CHANGED	hLRspph+pNAlphIpplPsDscKPlVlpIp-tTRoLpQNu+hWAhLsDlScQV.WaG++LssEsWKslFsuuh....tpcp-slPGL-G.thVslGpSTu+MoVpcMu-LIEhlpAaGsppGV+aoD	..............................lRs.thppNAIpAl.pl.......Ds......ppPl..hlpIp..-.....p..RolcQNp+hW.A.hLsDlSR.QV.W....H.......Gc....hLssEs.WKslFTAuh..........t............p.....Q............cslPG......l........-G.GhV.....hlG.psTS+MpVuchsELIElhtuFGs.E+.G..V+aSD.................................	0	2	15	21
+5601	PF05773	RWD		RWD domain	Bateman A	anon	Pfam-B_3991 (release 8.0)	Domain	This domain was identified in WD40 repeat proteins and Ring finger domain proteins [1]. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain [1] after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null --hand HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.71	0.71	-4.18	119	1878	2012-10-02 15:28:41	2003-04-07 12:59:11	17	79	325	8	1276	2204	23	119.30	20	19.67	CHANGED	psp-.pppEl-uLpuIYs-ch....................................hpppsstphplpl........................................................ptt.sphs............................................................................slpLphphsp...sYP.ppsPt.lp...lpsstttt...........................................tphpplpppLpchhppth.....G.pshlaslhphlp-..hl	...............................................................................................................................................................................................................................................................ctpppElcsLpu..I.Y..scph..............................................................................htpt.s.s..p..h.p....lpl.................................................................tt.ttsthh..................................................................................................................................................................................................................................................sl..p..Lp..l..p.....hPp.......sY..P..p......psPh..lp.....lpsttthp...............................................tphp.p..l.tppLpphhppth.....G..psh.lasllphlp-..h...............................................................................................	0	383	606	961
+5602	PF05774	Herpes_heli_pri		Herpesvirus helicase-primase complex component	Moxon SJ	anon	Pfam-B_7045 (release 8.0)	Family	This family consists of several helicase-primase complex components from the Gammaherpesviruses.	25.00	25.00	53.10	50.20	21.00	18.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.59	0.71	-4.15	8	24	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	19	0	0	23	0	125.00	30	37.95	CHANGED	Wl-oLphslsLhh...ssps.psILcslLslhassRcsTsFWLLPpualpptsppPslPhDCluPp.halhTcsGshp.Whs-asLPsslsYpsYlppllclhphlp.t..sstpscph..hL-sapplLsLF	..WlssLshslslhh...ssho.tsllcpllslhappR+sosFWLlPpsaspthshp.PslPhDCluPp.halhTpsGshp.WhtshsLPsslsYthYlpphlclhphl.........ssppscphp.hL-tapplLsLF................	0	0	0	0
+5603	PF05775	AfaD		Enterobacteria AfaD invasin protein	Moxon SJ	anon	Pfam-B_7107 (release 8.0)	Family	This family consists of several AfaD and related proteins from Escherichia coli and Salmonella bacteria. The afa gene clusters encode an afimbrial adhesive sheath produced by Escherichia coli. The adhesive sheath is composed of two proteins, AfaD and AfaE, which are independently exposed at the bacterial cell surface.  AfaE is required for bacterial adhesion to HeLa cells and AfaD for the uptake of adherent bacteria into these cells [1]. 	21.50	21.50	22.50	34.00	20.00	21.40	hmmbuild  --amino -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.20	0.72	-4.10	10	168	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	136	11	1	79	0	107.60	55	72.60	CHANGED	+cshuupL+DGt+lATGRIhCREsHTGFHlWhNuRQssG+PG+YIlQGp+DopHcLRVRluGpGWpssst-GtpGllppGpE-QshFDVhsDGNQplsPsEYllSVSGpCl	...sh..FRAGHVPDGMVLAQGaVTYHGSHSGFRVWSDEQKAGNTPsVLLLSGQQDPRHHIQVRLEGEGWQPDsVsG.RGAILRTAADNASFSVVVDGNQEVPADTWTLDFKA...CAL.	0	0	0	1
+5604	PF05776	Papilloma_E5A		Papillomavirus E5A protein	Moxon SJ	anon	Pfam-B_7244 (release 8.0)	Family	Human papillomaviruses (HPVs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. The kinetics of E5a protein expression during the complete viral life cycle has been studied and the highest level was found to be coincidental with the onset of virion morphogenesis [1]. 	25.00	25.00	130.60	130.50	22.80	20.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.22	0.72	-3.83	5	25	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	0	0	24	0	91.00	80	99.74	CHANGED	M-VVPVDlTssTTSsSLLPLVIALTVCllSIILIIhISEFlVYTSVLVLTLLLYLLLWLLLTTPLQFYLLTLSLCFLPAFslHQYILQTQQ	MEVVPVQIAAGTTSTLILPVlIAFsVCFVSIILIlaISDFlVYTSVLVLTLLLYLLLWLLLTTPLQFFLLTLhVCYhPAhYIHpYIVpTQQ.	0	0	0	0
+5605	PF05777	Acp26Ab		Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)	Moxon SJ	anon	Pfam-B_7275 (release 8.0)	Family	This family consists of accessory gland-specific 26Ab peptides or male accessory gland secretory protein 355B from different Drosophila species. Drosophila males, like males of most other insects, transfer a group of specific proteins (Acp26Ab and Acp26Aa in Drosophila) to the females during mating. These proteins are produced primarily in the accessory gland and are likely to influence the female's reproduction [1]. 	25.00	25.00	31.40	30.60	22.10	18.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.05	0.72	-3.54	4	17	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	8	0	2	28	0	88.50	77	86.89	CHANGED	MNYFAVLCIFSCICLWQFSDAAPFISVQSSSQSRSQKVMNGMLRTLYDYSVQDSVNDATGHLIHTHKADFNSDVMSP-EIEpVRQQLNMA	..........MNYFAVLCIFSCICLWQFSDAAPFISVQSSSQSRSQKVMNGMLRTLYDYSVQDoVNDATGHLI+THKSDFNSDVMSPEEIE+VRQQLsMA....	0	1	1	1
+5606	PF05778	Apo-CIII		Apolipoprotein CIII (Apo-CIII)	Moxon SJ	anon	Pfam-B_7283 (release 8.0)	Family	This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesised in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma [1].	27.10	27.10	27.20	29.20	27.00	27.00	hmmbuild  --amino -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.30	0.72	-4.59	6	42	2009-09-11 01:40:59	2003-04-07 12:59:11	7	2	27	1	16	35	0	65.00	61	62.42	CHANGED	EsE-uSLLuhMQGYMcpATKTApDALoSVQESQVAQpARGWMT-SFSSLKDYWSoFKGKFTsFWDSsPcs	..........EuEDsSLLuhMQG....YMp+ATKTApDALo.SVQESQVAQQA.....R..sWhTDuFSSLKDYWSoh+sKaSt..FWD.sPE.s.......	0	1	1	1
+5609	PF05781	MRVI1		MRVI1 protein	Moxon SJ	anon	Pfam-B_7407 (release 8.0)	Family	This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumour suppressor gene [1]. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP [2]. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins [3].	20.10	20.10	20.40	20.80	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	538	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.63	0.70	-6.11	3	180	2009-09-11 20:56:11	2003-04-07 12:59:11	7	5	50	0	88	165	0	389.00	34	73.00	CHANGED	psEPcDGALDVsRsppCPuPTusPlPGssLpGCsRMN-DsSp-ENGVG+ssuESluQpREhhspsSS.PL.RtTSSo-GTlTSS-sGp-ILsMASsDLDcKsLCcKEE-sRAASPslc...........tQGTSLAc-sIuhpsSsuVuKslspLEAuEE.E.......ToEpccKESAuG-oVlSslPcsoVKpVNl+QSENTSA...NEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCE-DNQAQEIlKKLEKSIslLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQlLLQN-.SRSssPsEDDsspptRSpSLSL.SKPSSLRRVTIASLPR..........................NlGNsGhVSGMENNDRFSRRSSSWRILGoKQSEHRPSLhRFISTYSWADAEEE..........Ks-lKs+DssEPpGEEsVERTRKPSLSE++usTpcWD+uolsSolASWVTaLQuSaRKAN...+ALWLouAhIlLlAALMSFLTGQLFQouVEAAPTQpGDSWsS.LEHILWPFTRLpH-GPPPV	....................................................................................................................................................................................................................................................................................................................s.t.....t...h..t....t............................t.tthh..sps.hshth.ph.ptttE.c..........................s.t.ttc.....ttt.s........u.s..hs...s.s.l+..lphppu.ssSA......sEKEVEs.FlpLSLuF+sD.aTLEpRlp.tERpRsLsEENhcKEl.....p......Nhht.lp...........u.................ssL..cc..sptpEhhpKL.csIshLpphssRluSRAEhlGAlpQEpR.hS.KAsEVMhQaVENLKRh.YtK-HAEL.EhKp..lh.QNp....Ru.h....s.s.........-D....tssp...ph..+p.Shs...uKs...shRRVolAslP+............................................shtss...............s.s........s...h.s..t+sss.....t.s....s..........s.......c.hp...hsc.p--...........p...t......................................t...............p...h...hh...h...h..phs.......phlhh.h.hhh...llhshlhuhh.t...h....p.s....tts.....................................................................................................................................................	0	15	22	50
+5610	PF05782	ECM1		Extracellular matrix protein 1 (ECM1)	Moxon SJ	anon	Pfam-B_7421 (release 8.0)	Family	This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis [1,2]. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness [3].	25.00	25.00	27.80	27.80	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	544	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.10	0.70	-5.79	3	78	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	33	0	30	80	0	339.00	43	97.22	CHANGED	MGTsSRAALVLACLAVASAASEGGFKASGQRELsPE.LhpHLQEVGYAAPPSPPLSRuLPhDHPcTSQHuPP.FEGQSEVQPPPS.EshPl.pEch.sh..Ps.ccsGPslPQEAIPLQKELPPPQVPIE...............QKEsKPAPhuDQSPPEPESWNPAQHCQQGRsRGGWGHRLDGFPPGRPSPDNLcQICLPsRQHVVYGPWNLPQTGYSHLSRQGETLNlLETGYSRCCRCRS+TNRLDCAKLVWE-uhoRFCEAEFSVKTpPHhCCp+QGEARhSCFQEEAPpPHYQLRACPSHQPsIS.G.ELPFPPGlPTlDNIKNICHL+RFRSVPRNLPATDslQRpL.ALhpLEtEFQRCCRQGNNHTCTWKAWEDTLDGYCDREhAIKTHHHSCC+YPPSPsRDECFARRAPYPNYDRDILTLDLSRVTPNLMGHLCGNpRVLSKHKQIPGLIQNMTARCCDLPFPEQACCAEEEKLAFI--LCGPRRNhWRDPALCCcLSPGDEQINCFNTNYLRNVALVoGDTcNAKG.GEQGPTpGTNuSPTSEPKEE	...........................................................................Mtsh.hAAhlLhhlAlsusAptGu..s.tphp.hP................................................................t....................t................................................tt.ls.Qpc...........t............................................................hp..t......u..l..sFPPGRPSs-NLppIClspRp+llYGPasLP.poGaSHLsRQGcslNhLEhGYopCC+...sp...s...p...spp.....LpCsc.sWccshppFCctEaSsKTpsa.CCp..pGpt..RhtCFpptuPpspY................................................................................................................................................................................................................................................................................................................	0	1	5	11
+5611	PF05783	DLIC		Dynein light intermediate chain (DLIC)	Moxon SJ	anon	Pfam-B_7447 (release 8.0)	Family	This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin [1,2]. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo [3]. 	19.70	11.00	19.90	11.00	19.60	10.90	hmmbuild  -o /dev/null HMM SEED	472	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.64	0.70	-5.82	8	500	2012-10-05 12:31:09	2003-04-07 12:59:11	6	6	234	0	324	498	9	276.10	25	71.25	CHANGED	-EGQNLWSuILSEVSTcucSKLPSGKsVLVhGEcGSGKTTLluKLQGsEcsKKGRGLEYLYlsV+DEDRDDhTRCsVWILDGDLYHKGLLKFAlstpslc-TLllhVlDMSRPWohM-SLpKWsSVLR-HIDKL+IPPEEh+-hEQ+ls+sFQ-YlEPt-sh.sGSPQRRsspssu.D--SllLPLu-slLTpNLGlPllVVCTKCDAhosLEKEHDY+DEHFDFIQuHIRRFCLQYGAuLIYTSVKE-....KNLDLLYKY..lVHKlYGFsFssPAlVVEKDAVFIPAGWDN-KKI.uILHENFpslKsEDsaEDhIsKPPVRKhVH-KEl..tAEDEQVFLhKQQSlLuKQPsTss.RssESPsRussGSPRsssRouPssVuSsuPhso.sKKsDPNlKsuusS.EGVLANFFNSLLoKKoGSPGusus......GGsssstsosstsos+KoGpKslLTDVQsELDRhSRKs-phls.ssu.Tps	........................................................................................................................................h..h......G.t...sp.p.hh.......h....................................t...................................................................u.....LtYha.............h.p...h....h....c............t......t...p.................p.................s....s.....h......h....pha..L.s....s.s.....h....ts....Ll.p.....l.s...psl.....phhlhhhhDhop...P...W.hhcpL.pp.a.h.p.h....l....p.p.hl.......p..h.....p............pt...........h...p.....t.h.p.ph.p.hpp...................................................................................................................................t.......................s....h.....hhhhh..................tsc.h..............................h.tp.p......t.....hp....p..hDhl...hhRphhhth.......suu...Lha...h.s.........................ph....hh..p...............hhp.....h..............t.......................hhcpptlhlP.shDs.thI..thh...pth...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................pt...........................................................................................................	0	125	167	249
+5612	PF05784	Herpes_UL82_83		Betaherpesvirus UL82/83 protein N terminus	Moxon SJ	anon	Pfam-B_7466 (release 8.0)	Family	This family represents the N terminal region of the Betaherpesvirus UL82 and UL83 proteins. As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. Human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they enter the S phase, a cell cycle compartment that is presumably favourable for viral replication. The protein product of the human cytomegalovirus UL82 gene, pp71, can accelerate the movement of cells through the G(1) phase of the cell cycle. This activity would help infected cells reach the late G(1) arrest point sooner and thus may stimulate the infectious cycle. pp71 also induces DNA synthesis in quiescent cells, but a pp71 mutant protein that is unable to induce quiescent cells to enter the cell cycle still retains the ability to accelerate the G(1) phase. Thus, the mechanism through which pp71 accelerates G(1) cell cycle progression appears to be distinct from the one that it employs to induce quiescent cells to exit G(0) and subsequently enter the S phase [1]. 	20.70	20.70	20.80	23.10	19.10	20.40	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.80	0.70	-5.70	18	118	2012-10-03 01:18:03	2003-04-07 12:59:11	6	1	26	1	0	132	0	340.30	31	63.36	CHANGED	shs.luspllphlh.pscsslcPcEs+llcTGlsVpVsp.sollhlsp.sspspssht.pp...........LplKapshcsp.-hcs.lslsVpN.os+s...lssus..pPl.ulhVFALPLstVslssLplaps.............htppth.pssucsslpphstphWplRlsloplpWscppsphhtsshhasosFhhpspshPLptl.sssc.lsCSptssplp+sphhscs....hlhlaL......phpppsPPsplFlplul.hspp......................sclshp+NPcPaLp.pscNGFslhsP+slplp.sscpsplhlsssFcSsp.asulFhPpsIPGlSlsssshhsppslhlclpuhpc.slplcthpsLGtl+FFs+shlhh	.........................................s.hu.luspllptlhspssssltPcET+lLpTG.lclpVsp.PSllhlsQhsscussspp.ppp..........Lplpasshs....sp.-hc..s...lsVsVpNsosRs...lsPup...csh.ulhVaALPLchVslsslsla+h............tscccp..+phssscAslctssp.....phWpsRlTVoslsWs+ppsphp......t......ss......h.hasouFlhsspslsLp..........p......l.s........sAcpLsCS.tsTpls+hpllscp....hlplal..........cp.hspss..P..sspLFhHlsl.pspc.......................tcl.shpRNPpP.ah..+s.a.c....cN.GFp..VlsP+shtl+.sGchsplhlcsuFpS..cp..ahuLhhPcsI.P.GLSIpsshlhsspplhlclpuhtc.slclcthpslGtlaFFcpchlh.t...	0	0	0	0
+5613	PF05785	CNF1		Rho-activating domain of cytotoxic necrotizing factor	Moxon SJ	anon	Pfam-B_7489 (release 8.0)	Domain	This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells [1]. Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain [2].	25.00	25.00	131.30	130.50	18.00	15.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.69	0.70	-5.50	10	55	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	44	2	6	44	0	278.90	37	34.56	CHANGED	slpphushs...hppLspGsIslLKG+Glluu+cspp..............Plshhlshl+aDsss.h.t.........pupDpshaG.lhuhsGssltsopsu.....PuoslGpaasptsLosNlsll+VsNGsRGssGl+IsLs-lpcupPlllTuGsLSGCTolsApKcshlYtaHsGps.sstusWhTup-GVpplhcstpsLupsssPslssspNNs.LV-aLucsFDpulIsYsG+sccssut.t........cNVslFDYsts.hscpstsRlGsuhsLlo.ssssslsVpoLuEDhslN..ususchsVL.ss.....h.Ksh	..............phupps...hptLs+GsIslLKGRGsluup+pps..............sl.FhIphsRaDp................puhDphhas.hhuhsGhshhss.su.....suohhupaacchsLospssII+VsNusRGssGIKIsLc-VpcupPlIlTuGsLSGCTTlsApKcuYlYthHTGpo.pshusa.TussGVpphhcshchLstps..hspltshhssD.LVsYhScsF-culIsYsuppcpssupht........cNVslFsY..h.hpshs.hthGsuhTlls.pssGslslpoLuEshulN..usssphslLps................	0	1	1	3
+5614	PF05786	Cnd2	Barren;	Condensin complex subunit 2	Moxon SJ	anon	Pfam-B_7477 (release 8.0)	Family	This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons.  Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localises to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase [1]. This family forms one of the three non-structural maintenance of chromosomes (SMC) subunits of the mitotic condensation complex along with Cnd1 and Cnd3 [4].	21.70	21.70	22.10	21.70	20.80	21.60	hmmbuild  -o /dev/null HMM SEED	725	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-13.54	0.70	-6.02	15	462	2009-12-23 17:17:02	2003-04-07 12:59:11	9	6	285	0	333	491	3	510.80	21	88.67	CHANGED	psp.t+psstusptchsoshp........lshNDDptE+ppR...........................RRhosh-ttsopsuuss.u...........st.pshhshhps.pIhpsacpClKLuo-NKIsscNuWshsLIDahsDl...ppK-u-hsNFQhAusTLDAusKIYusRVDSVas-shKlLuGL......u..p..pcspcpss-G..ss-sc-s-utthtpcsspcKs.++K..RsstuTls.shsslslp+h-hchsVDPLFpKsuAsF..DEsuupGLhLNpL.ulDupuRl.....lFDSs-sst.............................ppupsschssssplDhosLt..................................hs.Lspl-cpsICPSLssap..hs-sst..s..Fsctsp-hcs-sht..ttt...............shs-ctp.tshuFDlsu-sts.....................stusuG-ttphcstpEsh.cspcspccsspht-s.tssD....hshsLst........s.hSYFs.sphppsWAGP-HWKaR+h+.................pscsssposut+pKKc.KcshclDFsssl-....-hhFp.ssusoslohsphpppscspsh.LPsDhHasscpLl+LaLKPps+hsp............hs.cpcssspsss-hD-h.asNpp.....................tsDssshhPsh.utssD.-DDstsFsDssshh..ps.st..t.sutttstt.t.shhshhtsplhusP....................++Vphl.VsYA+sAK+lDh++LKpshWphlscph.sssp.ts..................................ctp-psppssptpFoplhpsLtshhP.sphtcslSsShuFlCLLHLANE+sLpLpss-s........L-DlhIpps	..........................................................................................................................................t......................................................................................................................................................................................................t.hpph.hch..scN.KIsttNsa....s....ht.LIDhhtp..h........................c........p....t....p....hN............F...ph.....A.........usoL-u....ssKIYs.RVDulhs-sh+llusL................................s..........t..t.............................t....t..t...t.................t.........................................t..t.........t.............t.........................t.........p...t.................t..T.l..phttlp..pph..-.........t.....h....DPhFtph..........sth..D.susttl.hhs.L...............t.pl.......hhsst........................................................................................................................h.............................................................t..l.....htth............................................................................................................................................................................................h.......................................................................................................................................................................................................................................Wt.u.......t.....aWpht..................................................................................p..p.t..............h.pa.........t......................h...h.t....................................................................................h..............................................................................hP......c.hth..t.h.ph.......hst..h.........................................................................t...........tt............................................................................................................................t......................................................................................................................h....s...............................................h..t.....l.aschu..KphDh+tLKpthap.ht.........................................................................................................................h.hpplhpt.l.....p..hs..............hpp.......lS..hhFhslLHLANEptL.l.....t...........tp...............................................................................................................................................................................................................................................	0	132	200	290
+5615	PF05787	DUF839		Bacterial protein of unknown function (DUF839)	Moxon SJ	anon	Pfam-B_7480 (release 8.0)	Domain	This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	524	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.90	0.70	-5.57	15	1732	2012-10-05 17:30:42	2003-04-07 12:59:11	8	25	946	0	506	2061	586	374.30	27	79.74	CHANGED	hsauslssssD.....chlsVPcGYchcllspWGD.lhss.Pth......s..tptt.hGhNpDGMuhFsl.......................sps.....+s.LLlsNHEYsssslhh.......................tstshstcpVptthAAtGsTllpl.c...ttta.hs.suthNRR...........................lptso.h.l..sGPsuGppll+ot...........ts.spGsplhGThsNCAGGsTPWGTaLTCEENhss...hFus....................pphG.....sth...........pFs...............sccaGaVVElDPhcP..posPhK+TALGRFpHEusslh..csuR.sVlYhGDD...cpssahY+FVsscphpsts.....ttspsLh-sGsLpVA+hsss....................GsscWlsLs.s............................................................ps....st..htsts-lhlpsRhAA.ctlGAT+McRPEslt.ps..h.....cVYhshTNss.tp......................h.....ssuNsRscNtaGpIh+ah.sss.....phsstp.pW-LalhuGsstssp.........s.stsshhssPDNlshDstGcLWlsTDGssst.t.......................huts.G......h.sts..pup.chhh.ssPtsuEhsGssFoPDucThFVslQHPG	..................................................................................................................................................h...............................................................................................................................................................................................................................................................................................................................................................................................................hhG.hh.sCus.u.o.PWsThlosEENhss............hF..s.st..tt............................t.p+.h...G.h....t...h....................................................................ca.shs..................spspcaG..allE..l..D....P..........hss......p....us.......s........h.......K+TA..LGRFpHEsst.h.h.............t.....s....sp......hlsYh.GDD..........pp.p.alYKFVuptthp.t.................tts.ph......L......s......pGsLYV..A+.a.s.ss........................................................GsspWl.Ls..s..............................................................................................hp...................tss.....h..s..tspl...h..l..s.RhAA.shhGA.....T........hcRsE.ht.p..st..................phahshop.t..........................................................................................Gt.l.h..t..h............t...................................t....h...............h......h.........s.................................................hssPDsh...h.h....s...............h.......l.h.l..pD.t............................................................................................................................................................................................................................................................	0	144	336	453
+5616	PF05788	Orbi_VP1	Orbivirus_VP1; 	Orbivirus RNA-dependent RNA polymerase (VP1)	Moxon SJ	anon	Pfam-B_7493 (release 8.0)	Family	This family consists of the RNA-dependent RNA polymerase protein VP1 from the Orbiviruses. VP1 may have both enzymatic and structural roles in the virus life cycle [1].	20.00	20.00	20.30	32.30	17.50	19.90	hmmbuild  -o /dev/null HMM SEED	1301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.07	0.70	-14.19	0.70	-7.37	6	192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	69	0	1	156	0	507.60	51	99.54	CHANGED	VQsApLl+RulpRlhpGI+hctscutshYYKaS-phR+hRcK+GspYK+-s-.hE+phchptcpLYGLPVl+EuSWc-lhs...hpphppssLclalcSlLchp-L-PEEEFLRNY+Vp......cphpshp-FVEpRA+sEhQlaGDlslKtWsuhLhElupphKHpPLGLpVMucFVpRFGpPFHQNsRDLSQlcDashsYooPLLFEMCssESllEFNhhhRM+EEsIppLEFGsp+lsPhcLlREhFllCLPHPKKINNhLRAPYSWFVKhWGVGucclhVLpStGGDDRNSK-VhYssF++hpNhYu.slh+SpFYpco+cpNhpKlcEtlpYSQ-LGsHshshPlF.+ML+sVYpTsFsPpchSHlILASahLSIQTITGYGRAWVKNsuoDhEKQhKPssuNhlsRVsDhT+N.FIQAYpEAcc+GE-IVpPEDMYTShLRLA+NTSSGFSTplpVhK+YGPshc.+cpchI+IsSRIKALVIFpcGHcIFssEpLcKKYNTVE.YQoKGSRDVPIKATRhIYSINLSVLlPQLIVTLPLNEYFu+lGGSTpP-s++lGGKIIVGDLEATGSRVhDAADTFRNSuD.sIhTIAIDYSEYDTHLT.aNFRpGMlpGIRcAMp+YpcLRYEGaTL-ElIEaGYGEGRVssTLWNGKR+V.hKhsh-cYhpLsEp-Rl...cGsFK.sPhGVhPl+slclsp+lplc.Dsc-hlLVuPsDGSDLAh..lsTHLSG.ENoTLlhNShHNLAIGTlIQEElp+cssslloFhSEQYVGDDTLFYTpLpspcscthDpllcTIF-TIt+sGHEASsSKThhsPFSVEKTQTHAKQGlYIPQDRMMlISSERRKDIEDVpGYlRSQVQThlTKlSRGFSH-LAplILMhKToFlGaRKhKRTIhEsGtYRDR+FDSscEDGFTLhhlRsPLsLYlPV-WNGaGAHPuALNlVMTEEhFlDSlhhuphc-hhtPlh+Ihsss.PsWNETpuDKRtlsTcTKMSFFSKMARPsVpoVLsssElhctVcpLPLG-FSPspIS+TMMHSALLKEspARoLLoPsYEl-YQKplNsWlp.psshphpup-hpISTsYsKlFcVhFEsshtpuhhh..FPD.NLSPp.Fa.QKhhlGsRhSsRsRhSY.VDRIDSILRuDVVMRG.......FITuNpIlslLEclGhsHSAuDLshlFolMNl-s+VAE+LupYIsp-KIRFDAhKL.K+GICGDEFSMSLDVCTQsMlDcal+aP+pLTKTEhDAVsLYsSQllMLRAApGlshp+hclsVosEcK++aKVRtsRFpoHlPKh+hlK+L.hshcRLSuRhlpNQFV	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LaYscLpopctphhsphhpsIFsTVtKCGHEASsSKThhsPaSV................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+5617	PF05789	Baculo_VP1054		Baculovirus VP1054 protein	Moxon SJ	anon	Pfam-B_7511 (release 8.0)	Family	This family consists of several VP1054 proteins from the Baculoviruses. VP1054 is a virus structural protein required for nucleocapsid assembly [1]. 	20.40	20.40	49.70	49.00	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.26	29	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	57	0	0	56	0	332.90	39	96.61	CHANGED	phspsso.+.ss.a+Pl+h.s+.pQC.hHPpRANC+lh+hhs..........c.........................pshh.HhThl.sshahshsscPYYphLlpspt...shtt.httahNAsphhshlplc.......sssEcahuI-EAGEpNhshl+hVlKslhchlss.s...............schYl.lhhcchalDhlYSph+sl.lLPQcMYslappp...................ptP..hsphhphholPps-c.........uhpSQ.IY+oFLlYNTVLTMhLKQpNPFN-..psKsIShIlRsLGpCP.....sN+sRlKsC-LpaGGs.sP..GHlMCPP+-MVK+Ia+YAKWshsPNNY+RYacLIsc.sshps......................t..shhLhDWhsFlssFpsYFh	....................hspCsS.K.sP.a+Pl+h.s+.sQChlHPp.RANC+lh+phs..........s..ps....................pshh.HhThl.sshahshsscPYYptLLpssp.....................phtt..RttalNAs.phhshVplc.......sssEcFhuIDEAGE+Nhssl+hVl+slhchhss.s...............schal.LhlDchalDllYStaRsl.lLPQchhslhpcp......................ptP..hsphhphhsVPso--.........uhpSQhIY+oFLlYNTVLTMlLKQsNPFNs..psKsISlIlRsLG+CP.....sNK-RlKCC-LpY...GGs.sP..GHlMCPPREMVK+IFHYAKWscsPNNY+RYa-LIsc.ss.ps.th..........s.tt..t.ts..sLhLhDW.NFls-FpsYFh............................................	0	0	0	0
+5618	PF05790	C2-set	CD2;	Immunoglobulin C2-set domain	Bateman A, Finn RD, Moxon SJ	anon	Bateman A	Domain	\N	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.70	0.72	-4.01	27	320	2012-10-03 02:52:13	2003-04-07 12:59:11	10	44	68	56	79	345	1	77.80	26	27.95	CHANGED	losssss.ssLss-sLphs....s.hhp.plphcp.ppKs.cspphhhshp...p-sG.sapChsp......sts.pphpsshpl.shs	.....hosssts.plLss-sLsho..h.t..s....s.hh.p.plp..hcs....stKs....h.....cspphhhshp..hp-sG.sapCpsp.........sps.pphpsphpl.s.........	0	5	5	12
+5619	PF05791	Bacillus_HBL		Bacillus haemolytic enterotoxin (HBL)	Moxon SJ	anon	Pfam-B_7539 (release 8.0)	Family	This family consists of several Bacillus haemolytic enterotoxins (HblC, HblD, HblA, NheA, and NheB) which can cause food poisoning in humans [1].	25.00	25.00	25.00	25.80	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.05	0.71	-4.92	13	739	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	144	1	36	537	0	178.80	32	47.98	CHANGED	pNhSLu..spshpculcptGSpshlhssYuhhIlpQsslslsslo..sh.sph.tslhpcQcsA+sNAppWlDphKPpllpssQsIlsYsTpFpsYYssLlpsl.....-ppD+sshpsslscLpspIppNQcsscpllp-LpsF+splscDopsFpscs......splpsILpuss.AsIstLcpcIpshpssIpps.s	.......................................phths..stthppshpphGuphhhhphYuhhllppPslshpslo..p..sth.tslhpcQc.A+tsAppWlsph.KPQLlc.TspsIlsYs.....T.....p.....F.....psYYsoLlpsl...............sppDpssLpc....uls.cL....p....s....p....IppNQppsppll....p-Lpca+s.plspDspsFpscs......splpuILtups.usIstLppcIpphpssIptp..p........	0	14	21	23
+5620	PF05792	Candida_ALS		Candida agglutinin-like (ALS)	Moxon SJ	anon	Pfam-B_7578 (release 8.0)	Repeat	This family consists of several agglutinin-like proteins from different Candida species. ALS genes of Candida albicans encode a family of cell-surface glycoproteins with a three-domain structure. Each Als protein has a relatively conserved N-terminal domain, a central domain consisting of a tandemly repeated motif of variable number, and a serine-threonine-rich C-terminal domain that is relatively variable across the family. The ALS family exhibits several types of variability that indicate the importance of considering strain and allelic differences when studying ALS genes and their encoded proteins [1]. Fungal adhesins, which include sexual agglutinins, virulence factors, and flocculins, are surface proteins that mediate cell-cell and cell-environment interactions. It is possible that both the serine/threonine-rich domain and the cysteine residues in the C-terminal and DIPSY Pfam:PF11763 participate in anchoring the terminal domains inside the wall, so that only the inner part of Map4p, including the repeat region, is sticking out as a fold-back loop then able to act in adhesing [3].	25.00	11.00	25.00	11.00	24.50	10.90	hmmbuild  --amino -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.61	0.72	-3.82	189	1619	2010-01-07 11:49:09	2003-04-07 12:59:11	8	56	22	0	1025	1644	0	32.10	46	32.08	CHANGED	sThT.phWoGohsoTsTh...oss.....PGtTsTVl..Vp.lP	.................sTsT..pa..Wo....t.S.h.sTToTl...Tss.......PG.u.TcTVl...lc..P.....	0	289	393	1025
+5621	PF05793	TFIIF_alpha	TFIIF-alpha; 	Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)	Moxon SJ	anon	Pfam-B_7586 (release 8.0)	Family	Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	528	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-13.00	0.70	-6.13	8	332	2009-01-15 18:05:59	2003-04-07 12:59:11	7	11	190	9	210	310	2	299.90	25	69.07	CHANGED	uut...suos.spslpEYsVRVspsscK.+YalMR.......FNupcsV-hspWs...tsphER-.s.+.hht.pphh.-hGtGSEas+stREEuRRK+aGh..+ca+.-sQPWlLchst.c-G..+pF+Gl+EGGsoEpAoYYlFs+ss-uu.FcAaPlspWYNFsPlApYKsLThEEAEEcappR+KThNtFslhhhKthpss.s.hu-csE-c-t....pKuGsG+u+.....L+I+DhpsD--.-ussS-pu-ED--Etts.+Kc......s+hAKN+Kp..sDpK+p+RsuD-...-sh-.DS-DGD-EG+EhDYhSDsuusus-.-..........................E+E-hhusEcssKt-.cQs-cs-EcE-EcsEc-ut.SKctKKsKK.psKpsch..c-Sp-s-sSD-SDsDs-susshhpspKpKc.t+-EslsSusSusssStPupPossstsopuKRKhs...........spsSpsPsSsssKKlKhEssPpSs.tKuhPso.St................ssossuu-hslTEEsVRRYLh.RKPhTTpELLsKF+sKpssLSoEcsV.....sshApILK.+IsPlpKshpsphahsL+p	.........................................................t......................................................................................................................................................................................c.t..PWhlc......c.s...........tta.G..hcu.u.s...........ssahl.hh.......st.....t...hphhPhppa..YpFp.htpapsLohEEAEptht..++pp....s.t..h.hh..+th..t..tt........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	63	99	165
+5622	PF05794	Tcp11		T-complex protein 11	Moxon SJ	anon	Pfam-B_7604 (release 8.0)	Family	This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility [1,2,3]. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants [4].	20.40	20.40	21.80	20.70	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.33	0.70	-5.77	30	596	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	254	0	373	557	18	379.30	23	61.79	CHANGED	pLtH-Ishs.shph+...Ps.su.cu+hKcphpcsaW-tlppplstt....................sPpasphlpLhppl+-hLhSLL...ss+h+spIsElLDh.-LlpQQhc.+GulD...hsphupalhslhtphCAPhRD-tlpchpppl...................pclVptLRtIFplL-hMKlDhANapIpshRPhLhcso.V-YE+ctFpphl...p+sssslssopcWhpcstscthpphpptst.............................................t.ss.ssh.llhpuhlcL..lhptptspsFPETLhhDpsRLtpL+splppLsslusslllhpshlssthpss.........sphhs+lppplhsLlpt......sss+hscslpsIu.plspp............htpshsppstsslssshpsslputLtphhpss.ssVhplhcp+lhphlhstlh...............................ssspcshsssssshs.ht.............................ElpplupphspLssashpVaGs.aYhch..........lpph	............................................lhH-l.hs.phphc......s...su.............psch+chht.....psaWctlppplptt..............................................................sph.s..phltL...h..p..pl+-....hLh.s.hl...............................sch.+...sp.....IpEsLDh.-ll.pQphc...pG.shc........................httlspalhsh...htp.hCAPhRDpt.lpphtp.h.........................................t.phVp..hl....+tlh....plLchMK....h...........DhsNatl.....p.hp.PhL..hppu...lpYEpptFpchl........................ppts.......sL...shoppWhppshpph.ht.ph..pts..............................................................................................s..sh..hlh..puhlpL............h..s......t......ct..h.P.E.TlhhDptRltplptphpplh.hhusshLlhpshht.t..h..s..............................t.hp..plt.phhhs....llpt.......................p....p.pp......sh.sls..ph..t.......................................................tsh..t.t..t....s...sh....s..p.p......t....h...........s.l.....t.p...hp...p......s.slhplhpp+lhhhl.shlh.................................................................................t.ttt.....h.shsh.......................................................................clttlst.thhp.lhthp.tVaus..hY.th....h....................................................................................................................................	1	87	166	269
+5623	PF05795	Plasmodium_Vir		Plasmodium vivax Vir protein	Moxon SJ	anon	Pfam-B_7631 (release 8.0)	Family	This family consists of several Vir proteins specific to Plasmodium vivax. The vir genes are present at about 600-1,000 copies per haploid genome and encode proteins that are immunovariant in natural infections, indicating that they may have a functional role in establishing chronic infection through antigenic variation [1]. 	25.50	25.50	25.80	25.70	25.20	25.40	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.73	0.70	-5.25	125	471	2012-10-01 19:45:41	2003-04-07 12:59:11	6	4	6	0	383	877	0	296.30	13	89.84	CHANGED	Lsutch.........Ycchsp........p.tp.........p.hsshCp.phpph.........pplp....clCpKlhctLc..hlsptp.pppct............ChalpYWlY-pltphhp......tp..p.h..hhsclhplhpph.ppth...........p.pt..............................................Cp..hphh....hcp..hcccKpLaDYacsacsIcpphpspspp..C..pp.Yh....................pYlpphppLYcc..a....ppp..Cspttp.................shCscahcp..ppcY.sPpslLspL.pCt.t.......................................tpttt...t...............tttht...t..t..........t.t...t..............................................................................................tt.....tth.....ss.hhshh........hh.hh.hhh.p.............................................htp.hppthtppppthpp.httphth.h.t.tstt...t........................pph.ls....Ypss	.......................................................................................................................................................................h....t......h.................th..........phh.p..phhp.hp.........htp.......ttp....................C..ahpYWl..hsplhphht.p.................hhpphhp..hhpph.p..pt.................p..pp..............................................C.p....h.ph........hsp...hcchKtLa-Yh.p.s.ap.pl...p..p.t.....h....p..stp.......pt....C....pp.ah..................................pYlpthtp..h.Ypp....h..........ppp.....Cspttp.................thC.pa...h.ph................pph..ps...p...plltpl....pstt..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hh....h.h.p.............................................................................................................................................................................................................................................................................................................................................................	0	0	1	300
+5624	PF05796	Chordopox_G2		Chordopoxvirus protein G2	Moxon SJ	anon	Pfam-B_7672 (release 8.0)	Family	This family consists of several Chordopoxvirus isatin-beta-thiosemicarbazone dependent protein (protein G2) sequences. Inactivation of the gene coding for this protein renders the virus dependent upon isatin-beta-thiosemicarbazone (IBT) for growth [1].	25.00	25.00	126.20	126.00	18.50	18.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.37	0.70	-5.21	12	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	48	0	213.00	60	96.15	CHANGED	MsFR-LILFaLuKaLlTcsctuh+phlSLCRuFslchpcllscFhsp+hh+plopslppss.lLsElslsFPssll+-LlpLRLp+FsKslKtSh+LssshpGIsll.cspplhlhpsNDpLlsaLh+cYsPplYpYs.........stPsshsGu..............+lllCGhsploFasYhho.+IsoNpclcVlVT-pCIppLLp.tNtpLLcplF..c+usssls+sL+cIF....YSl	MPFRDLILFNLSKFLLTEDEESLElVSSLCRGFEISY-DLIoYFPDRKYHKaIsKVF.EHsD.LoEELSMEFpDTTLRDLVYLRLYKYSKsIRPCYKLu-NhKGIVVI.KDRNIYIREANDDLIEYLLKEYTPQIYTYSs.........E+ssIsGS......................KLILCGFSpVTFMAYTTS.HITTNKKVDVlVoKKCIDcLlDPINYQILpNLF..DKGSGTINKILRKIFYSV...	0	0	0	0
+5625	PF05797	Rep_4	Yeast_TAF; 	Yeast trans-acting factor (REP1/REP2)	Moxon SJ	anon	Pfam-B_7680 (release 8.0)	Family	This family consists of the yeast trans-acting factor B and C (REP1 and 2) proteins. The yeast plasmid stability system consists of two plasmid-coded proteins, Rep1 and Rep2, and a cis-acting locus, STB. The Rep proteins show both self- and cross-interactions in vivo and in vitro, and bind to the STB DNA with assistance from host factor(s). Within the yeast nucleus, the Rep1 and Rep2 proteins tightly associate with STB-containing plasmids into well organised plasmid foci that form a cohesive unit in partitioning. It is generally accepted that the protein-protein and DNA-protein interactions engendered by the Rep-STB system are central to plasmid partitioning. Point mutations in Rep1 that knock out interaction with Rep2 or with STB simultaneously block the ability of these Rep1 variants to support plasmid stability [1].	25.00	25.00	28.40	27.90	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.07	0.70	-5.74	6	16	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	15	0	5	17	0	267.80	26	83.62	CHANGED	pss+Elhphlp-shhhhshhslYsPppshllTs+GohplP-sYpcYPhLAlaYVpYhlpK.Pasll.s-L..-WP-PYVVlNTIh+RLpsH+ah.uNp.tsshs-cl+phIusul-IPpsp..csEhLsp.tKs+phstph..phh-s.ss+pclpcFFscLp-hsthushasshoKlclhlSCpuhh.upu.clphhApslR+lWltEhlhshsspcpc..tshDp..ssh-Dsp.....sptppsuus.p.scAp...........................uaWchlcsLpcp.p.pspp.pphchlAshlhuppcthtshpppRcpsRshLYhpl+thL.pphphpha+Gspshps.plKlSL+hpcp	......................................cth..hh.pshh.h...hla..tpp.l.T.pGhh.lPcpYtpa.hLAhhaltahhpp.sh.hh.ppl..-WPcPhlVhNTlhcRh.pH..h..tph..sthhppl+thlu.slphs.pt.....hht..tp.h.h..th..phhcs..sppclptFFphLpshsthtp.a.s.oKhhlhhSspshh.tps.phphhtpslRp.hltEhl.phhppcpp...hh-p..sst-Dsp.....sptp.su.stpsspup...........................thhp.lssLpcp.pspspp.sphchluthlhup.pt.tphphpppph+shlYh.l+thl.tsphplchYRGsphpps.slKlSL+.pp.....................	0	1	3	4
+5626	PF05798	Phage_FRD3		Bacteriophage FRD3 protein	Moxon SJ	anon	Pfam-B_7781 (release 8.0)	Family	This family consists of bacteriophage FRD3 proteins.	25.00	25.00	142.30	142.10	21.50	19.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.38	0.72	-3.66	4	35	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	31	0	0	15	0	75.30	80	99.28	CHANGED	MAKVsIDlVDFEYhEElIRNRYPELSIsSlpDopFaolplslpGPLEcLppFMsNEYCDGMcsEDAcFYhGLIcp	MAKVDIDIVDFEYIEEIIRNRYPELSITSlpDop.FhShQIVIEGPLEDLTRFMANEYCDGMDSEDAEFYMGLIEQ	0	0	0	0
+5628	PF05800	GvpO		Gas vesicle synthesis protein GvpO	Moxon SJ	anon	Pfam-B_8221 (release 8.0)	Family	This family consists of archaeal GvpO proteins which are required for gas vesicle synthesis [1]. The family also contains two related sequences from Streptomyces coelicolor. 	21.00	21.00	21.00	21.60	19.00	20.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.01	0.72	-4.12	17	117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	92	0	50	129	1	98.40	33	85.36	CHANGED	tppptt.ps.......sttssphhsht-shptAppshp-Lht+chEulsuspps-D.GWpl.VEVlEpptlPDTpDllupYElpLDssG-lhuYcRlcRYcRGchcp	...............................................tttt.................t..shhpshctAtpplscLhGcp...s-uVoulpps.......--...GWpltVEVlEh...p...RlP...c...Tssl.....LAp.....YEVpLDscGcLhuY+RlcRYpRGpsc.t...	0	17	39	48
+5629	PF05801	DUF840		Lagovirus protein of unknown function (DUF840)	Moxon SJ	anon	Pfam-B_8265 (release 8.0)	Family	This family consists of several Lagovirus sequences of unknown function, largely from rabbit hemorrhagic disease virus.	25.00	25.00	213.00	212.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.40	0.71	-3.95	2	29	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	9	0	0	26	0	113.10	93	97.04	CHANGED	MSEFlGLsLAGAusLSsALLRpQELtLQKQALEsGllLKAcQLupLGFNP.EVKsllV.GpuhspNhRLSNMHNDuSVVNuYsVhNPsSNGIRpKIKShNNSVKIYNTTGESss	MSEFIGLGLAGAGVLSNALLRRQELQLQKQALENGLVLKADQLGRLGFNPNEVKNVIV.GNuFSSNVRLSNMHNDASVVNAYNVYNPASNGIRKKIKSLNNSVKIYNTTGESSV	0	0	0	0
+5630	PF05802	EspB		Enterobacterial EspB protein	Moxon SJ	anon	Pfam-B_8424 (release 8.0)	Family	EspB is a type-III-secreted pore-forming protein of enteropathogenic Escherichia coli (EPEC) which is essential for EPEC pathogenesis [1]. EspB is also found in Citrobacter rodentium [2].	21.60	21.60	21.70	21.70	20.70	21.50	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.07	0.70	-5.48	3	178	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	139	0	5	79	2	257.00	53	97.58	CHANGED	MNTIDYNNQVhsVNSVSESTTGSuSuTAo.s.SIsSSLLTDGKVDISKLMLEIQKLLGKMVTlLQDYQQ+QLAQSYQIQQAVFESQNKAIEEKKAAATAALVGGAISSVLGILGSFAAINSATKGASDIAQKAoSASSKAlsAASEVATKALVKATESVADAAEEASSsMQQAMATATKAASRTSGVADDVAsSAQKASQlAE-AADAAQ....KASRlSRFhAAVDKITGSTAFVAVTSLAEGTKTLPTTISESVKSNHEINEQRAKSVENFQQGNLELYKQDVRRoQDDIASRLRDMToAARDLsDLQNRMGQSuRLAG	................................................................sNss.psTTsusu.s.ss...u.sSSLLTDG+VDls+LhLElQKLLtKMVslLQDYpQcQLuQSYpIQhAVFESQNKAI-E....K.KAA....ATA...ALlGG..hISSsL....GI.LGS.F.........A......Ah...N..s...AsKG..Au-lAp...p...su.S....sSSKu.......hs...AAS-....susKsLsKAoESlADss--AoSsMQpshsTss+AASRsSsVsDDlA....+ASphAEphADAAp....Ksuhhs+hhsuss+losoTsFlsVTSLAEGTKTLPTTlSESVKSsH-lsEQRhKSlENhQtuNL-hYKQ-VRRsQDDIsoRLRDhTossRDLh-l.NRMGQusRLAG....................................................	0	0	1	2
+5631	PF05803	Chordopox_L2		Chordopoxvirus L2 protein	Moxon SJ	anon	Pfam-B_8620 (release 8.0)	Family	This family consists of several Chordopoxvirus L2 proteins.	20.80	20.80	22.80	22.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.00	0.72	-4.36	8	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	40	0	0	39	1	87.00	50	96.83	CHANGED	AEVLhsKL+sIEp-NhhNEKllDCIIpE.IE+ppaalhRPhlRLllDllIllIVls.lhlRllKRNYplLLlhhhhYlhhchhtYhtl	...hEVIsDRLDDIVcQNlADEKFlDalI+t.LE+QsPuILRPllRLhIDlLLhVIVIhIFTlRLVsRNYphLLsLlslslsLslFhah..L......	0	0	0	0
+5632	PF05804	KAP		Kinesin-associated protein (KAP)	Moxon SJ	anon	Pfam-B_8674 (release 8.0)	Family	This family consists of several eukaryotic kinesin-associated (KAP) proteins. Kinesins are intracellular multimeric transport motor proteins that move cellular cargo on microtubule tracks. It has been shown that the sea urchin KRP85/95 holoenzyme associates with a KAP115 non-motor protein, forming a heterotrimeric complex in vitro, called the Kinesin-II [1].  	19.40	19.40	19.40	19.50	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	708	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.38	0.70	-13.27	0.70	-6.61	3	298	2012-10-11 20:01:00	2003-04-07 12:59:11	7	19	178	0	190	401	17	448.30	28	74.69	CHANGED	VKGGSIDVHPTEKALIVNYELEATILGEMGDPMLGERKECQKIIRLRSLNAsTDIAALAREVVEKCKLIHPSKLNEVEQLLYYLQNRKD.....................Spp+SGA+K+EpouKhK.................DPPPaEGsElDEVANINDIDEYIELLYEDlPEKVRGSALILQLARNPDNLEELppNETsLGALARVLREDWK+SVELATNIIYIFFCFSSFSQFHuLIsHYKIGALCMsVIDHELKRHEoWpEELsKKKK...........................ssEEcP.....................................ts...++DYEKSh.........................................KKY+GLlKKQEQLLRVAFYLLLNLAEDsKlELKMRNKNIV+MLVKALDRDNhELLILVVSFLKKLSIasENKNEMuEhsIVEKLsKLlPC-HEDLLNITLRLLLNLSFDTGLRsKMIplGhLPKLVtLLuNDNH+tIAlCVLYHlShDDKsKSMFTYTDCIPMlMKMllEsssERlDLELIALCINLAsNKRNAQLICEGNGL+hLM+RALKF+DPLLMKMIRNISQHDGPoKsQFIDYVGDLARIIops-DEEFVVECLGILANLTIPDLDYEhILpEFpLVPWIK-KLcPGAAEDDLVLEVVlhlGTVAsDDSCAALLAKSGII.SLIELLNAKQEDDEIVCQIIYVFYQMVFHEATREVIIKETQAPAYLIDLMHDKNsEIRKVCDNTLDIIAEaDEEWAKKIKLEKFRWHNSQWLEMVESQQhDDuEQhL.YGD-chE.....PYIpESDILDRPDL	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t........hs...h.hh.L..hNhA.s....p.c.ph..h.p..tt.hlth.....Ll.ch.l..p....p..p..s...h..-..lhh......slshlppLu..h.h...-.N.Ksph...........s..p...s..hltt.Ls+hh................s..p.p..........c........l..p....sh....t....hLhN.loas..s.th.Rp...phlp.sGhlP...hLs.thl.........s.....s..t..p..h..p..................h...s..h.....p.....h....Lhpluh.D.-.p........+..............t.hh.s...T.-..s..l.........................l.hph.................l...hp.s.......p...cl..p......h.p........h......h.hhhN.Lu.s.p.c.........hs...c......s.....pt.L....t.Lh.c...h.h.......p......t...........s....l...l...h...p...h...lRNl...S.....H.....................p.........h.h..p.............a.........lt...s............ls.t....l.t......t........c..p..........c...p....h.hcsluhLtNLsh.....t.........ph..hh........................................................................................................................................................................................................................................................................................................................................................................................................................................	0	77	116	158
+5633	PF05805	L6_membrane		L6 membrane protein	Moxon SJ	anon	Pfam-B_7771 (release 8.0)	Family	This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family [1]. Several members of this family have been implicated in human cancer [2,3].	21.80	21.80	64.80	59.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.36	0.71	-4.75	8	302	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	46	0	161	252	0	186.50	40	95.13	CHANGED	MCosKCuRClGhSLlsLALhsIlANlL.LaFPNG-TpYsocs+LSpaVWaFuGIlGGGLhhLhPAhVhluhcpcsCCGCCupEshGKRsuMLoSlluullGllGuuYCllVuulGLs-GPhChs......s.................pstWsYsFss......Tp...GpYLhDsolW.SpCpEPpHlV.WNVoLFSILLsluuLEhlLCLIQVlNGlLGsLCGhCps	........MCotpCu+ClGhoLlsLulhsllsNlL.LhFPsGcsp..h..sp...ps......plop.VWahuGllGuGlhhlhPAhhhlshtp.pssst.C...httt..t.supR......h..sM...h.....tSllhuslGllGusYChllSuluLtpGPhChh......................................sttWtYsFps.......................pt....usYL....h...s....p...ohW.........s....pChEPtplV.WNloLFSlLLsluslphlLChlQllNGllGslCGsCp.........................	0	6	14	57
+5634	PF05806	Noggin		Noggin	Moxon SJ	anon	Pfam-B_7925 (release 8.0)	Family	This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation [1].	19.60	19.60	19.60	19.80	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.83	0.70	-5.05	6	133	2012-10-02 16:54:34	2003-04-07 12:59:11	7	3	68	1	66	126	1	199.30	36	87.85	CHANGED	hllushhLLl.LslhhctusCQHYYhLRPlPS-sLPll-L+EcPDPlaDP+E+DLNETpL+slLGs.pFDssFMSltsP.c-ptuGs--Ls-.-L....p.sGhMPtEIKsL-F.Ds..hGKK+KsSKKL+R+LQhWLWuYoFCPVlYsWpDLGsRFWPRalKsGSCaSKRSCSVPEGMsCKPsKSsHLTlLRWRClp............................................................R+suhKCAWIPlQYPVIo-CKCSC	.................................................................s...............................................h.........p...Ds......hs....P+.pcL.spphL+phLGs.paDstaMuhs.P...t................t......h...s...u........sp...pl.s...t....p........tsthsp.-.l+....sL..-.h...c...........h.....Gp..+.....+..lu+....Kh+R+.......lp.WLWs.....o..a.....CPVhYsWpDLGsRFWPRYlKhGsC.h..o...c...+..S........CS..hPc..G.MsCKP.....u..cSsplolLRW+.C....p..................................................................................................................t..p..ss..ppCsWI.lpYPlIo-C+CSC..............................................................	0	19	27	47
+5636	PF05808	Podoplanin		Podoplanin	Moxon SJ	anon	Pfam-B_8548 (release 8.0)	Family	This family consists of several mammalian podoplanin like proteins which are thought to control specifically the unique shape of podocytes [1].	29.00	29.00	29.20	29.60	28.90	28.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.03	0.71	-4.68	4	44	2009-09-11 20:54:06	2003-04-07 12:59:11	6	2	33	1	24	54	0	151.90	41	76.82	CHANGED	MW+VPVLhaVLGSAhhWs.ApGuohsRs.......EDDlVTPGspDuhVTPGlEDplsTsGATct..ES.GhAPLVPsppEpsT+..hE-LPTstsosH-tcEppST........TTlpV.....VTSHSt-K.........su-ETpTTscKDGLuVVTLVGIIVGVLLAIGFlGGIIIVVh+KhSGRYSP	.......................................................................................................p..hhhhl.Gs..h...h..u.ttushs.s........EDsh.TsGht.sshshsGh..EDphsTsusopc...pS.uh.os.LVso...sspos.Ts.h.ph..EDhsT.s-ST.sHupcpopSs........Tss.sV.....sTSH..Ss-K................sss-TpTT......l-.KDGLuTVTLVGIIVGVLLAIGFIGGIIlVVhRKMSGRYS..........	0	4	6	8
+5638	PF05810	NinF		NinF protein	Moxon SJ	anon	Pfam-B_8528 (release 8.0)	Family	This family consists of several bacteriophage NinF proteins as well as related sequences from E. coli.	20.00	20.00	20.20	20.00	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.25	0.72	-4.17	4	198	2012-10-03 10:42:43	2003-04-07 12:59:11	7	3	178	0	2	84	1	53.30	71	91.73	CHANGED	MlsP.QspuYEpESltRAL.CAsCuppLcs.ElHVCEcCsAE.Lh.pDsNusMtEE.DDE	............MlsP.QshpYppESV-RALTCANCGQKLHVLEVHVCEcCCAE.LM.SDPNSSMYEE.-D-..........	0	0	0	1
+5639	PF05811	DUF842		Eukaryotic protein of unknown function (DUF842)	Moxon SJ	anon	Pfam-B_7096 (release 8.0)	Family	This family consists of a number of conserved eukaryotic proteins of unknown function. The sequences carry three sets of CxxxC motifs, which might suggest a type of zinc-finger formation.	23.80	23.80	24.00	23.80	22.60	23.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.28	0.71	-4.69	17	215	2009-09-11 00:15:37	2003-04-07 12:59:11	8	5	139	0	146	221	2	122.90	32	78.96	CHANGED	cppppclpsAlpphlsslpcphlhp...........hQtphF+CuscChpDpssoh-plppClEpCpsPltcAQphlpsElupFQsRLpRChhsCpDchcsth..p.s...ctchsp...phEpCsspClDcplsh.LPshhpph+csL	.....................................pttclptulpphlpslp+phl+p........................hQ...tthacCu.ApCCp....D.pps.......ohcpVppClE+CpsP.ltpA.QshlpsELppFQ...........sRL..pRCshpCpD+hcsp...hsss..s.p......c.phtp.............................ph-sCsspClDcahpl.lPshhcch+ps..............................	0	47	72	111
+5640	PF05812	Herpes_BLRF2		Herpesvirus BLRF2 protein	Moxon SJ	anon	Pfam-B_7251 (release 8.0)	Family	This family consists of several Herpesvirus BLRF2 proteins.	25.10	25.10	25.30	35.60	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.57	0.71	-4.29	15	36	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	23	6	0	31	0	118.10	37	90.26	CHANGED	sshohE-LsscLs+LchENKsLK+plppuss............Ps-chLTssQKEslIsusls+LoupApcKIEt+VcppssslVT+pph-cslpslolRlcVShc-.tht..............sps+pRRu+S+o+	.s.shohE-Lstclp+LplENKsLK+pltpuss............ssDphLTsspKEuhIsussstLsutAt+KIEt+V+ppsstlVT+pphpssLtslolRl-VSh--stht............t.sps+pRRutS+oR.....	0	0	0	0
+5641	PF05813	Orthopox_F7		Orthopoxvirus F7 protein	Moxon SJ	anon	Pfam-B_7318 (release 8.0)	Family	\N	25.00	25.00	36.50	36.50	24.60	18.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.93	0.72	-4.09	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	19	0	0	28	0	73.10	85	94.88	CHANGED	MTLVMGSCCGRFCDAKNKNKNKKEDVEEGGEGYYDYKNLNDLDEFpTRVEFGPLYMINEEKSDINTLDIKRRYRHAIESVYF	..MTLVMGSCCGRFCD...AKNKN......K..KEDlEEttEGCYsYKNLNDLDEu.sRlEFGPLYMINEEKSDINTLDIKRRYRHsIESVYF........	0	0	0	0
+5642	PF05814	DUF843		Baculovirus protein of unknown function (DUF843)	Moxon SJ	anon	Pfam-B_7353 (release 8.0)	Family	This family consists of several Baculovirus proteins of around 85 residues long with no known function.	22.50	22.50	22.60	22.50	22.10	22.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.81	0.72	-4.19	15	82	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	82	0	1	50	0	82.30	40	94.80	CHANGED	MhlhhshlsLIlluFlhsKspshSpLllhlLlLFVlFlhlLplYYl..ps-Ss.stDL.TccsK+lKKKpcLpcAFDAILNKNsSS	...............M.IhhhlLuLlslGhlhs+hcuhssLllhlLlhhllFhllLpl..a..hs..KT-Ss.spcl...o.p.K.....sKpsKKKRplppthDAllNKNpSS........	0	1	1	1
+5643	PF05815	DUF844		Baculovirus protein of unknown function (DUF844)	Moxon SJ	anon	Pfam-B_7453 (release 8.0)	Family	This family consists of several Baculovirus sequences of between 350 and 380 residues long. The family has no known function.	25.00	25.00	29.60	29.50	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.99	0.70	-5.60	22	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	52	0	0	57	0	349.20	38	96.85	CHANGED	MosltLFLcIEpLKNpl.DppMphsIWsKFFPLLu-s...solsLshspl.-FLsssAph.upsshsppNAAlsSQa..............sssssssssstss.tpslhNlass....sstsssssssshshppY+psspKllpYYo.usToSo-F+VpDlVtsMlYLu+oP+Y+PLapLLEssh.pc-h-ChPsloscphpsll-hLRsLhshsohplDapslclh+sohs+shN.PlsRaP+Vhlhpsts....lspDKcsol--Lll-Rh-tlppLcsQphlsu...ss+IPaCsDsphIscLl+h.hcsaslsRMaYNAsNoIFYsTMENYAssNCKFslsDYNpIF+shDpl+Ehspp......hppsttuDsLslhLusss	.MSsltLFLcI-pLKspI.DppMphsIWP+hFPLLuDs...sslsLshspl.pFLsssApt.upsshsssNAAlASQa...........ssssssssssssssstpsllNlFss........th.sspssssshshppaRpsspKllpaYoLssToSo-F+VpDlVhsMlYLu+oP+Y+PLapLLEssh.p--h-ChPshossphppllDhLRsLL-hPootlDasslclh+sohs+shN.PlsRas+lhlhpsss....lspDK+sTlEELllERuctIppLcPQQalsu...sscIPaCcDscFIscLlKh.hDsasLsRMaYNAANSlFYTTMENYAluNCKFslcDYNpIFKl.hDslR-hssp......hhtp..sppsDsLNlaLusts............	0	0	0	0
+5644	PF05816	TelA		Toxic anion resistance protein (TelA)	Moxon SJ	anon	Pfam-B_7534 (release 8.0)	Family	This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance [1] and plasmid fertility inhibition [2].	30.00	30.00	30.50	30.70	29.10	28.60	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.91	0.70	-5.73	81	1233	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	1042	0	200	815	46	325.10	30	86.17	CHANGED	pspphupplD.ts.tslhs.aGspsppphupaSpphLsp.V+sp..............-suslGchLspLh....pplcph-sschtt...ppp.shlu+..hhs.+httplpchhs+YpsspspIDpIhtpLpptcspLh+DsthL-phappshpaappLshYItAGchthpclcpph..lsthppcsp....tpt..hthpphs-hpphlptL-pRlpDLphsctlulQshPpIRLlQpsNppLscKIpouhssTlPlaKsplslAlsLtcQ+psscshpsls-sTN-LLppNA-hL+psoh-hs+pspcuslDlETLcps.psllsTl--shpIpp-upppRppsppcLpphpp-l+ppLhphc	..................................htphsppls..tsp.psllsaGsssQ..pphupaSp.phLsc.Vpsp.................-.lu.slGctLspLh.......pplcph.....ss....s-..l........ppc.shhp+....lFp...+...s...c..pslpchhs+YQslssplD+IshpLp+ppspLh+DhthL-pLY-pNppaacsLshaIhA.......Gctph.......pc.......lpsch..lPthppcup......sssQ..hshpplschpphl-cL-pRlpDLphu+plulQosPQIRhIQpsNpsLs-KIpoulhsTIPlaKsphslAlsLh+..Q+pussutctls-sTN-LLppNA-hLKpsslEsA+pspcuhl-l-T.......Lccotpsl...lpslpEohpIppcG+ccRptucpcLtphpp-lKpcLhp..p........................	0	65	133	162
+5645	PF05817	Ribophorin_II		Oligosaccharyltransferase subunit Ribophorin II	Moxon SJ	anon	Pfam-B_7633 (release 8.0)	Family	This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesised polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them [2][3].	21.30	21.30	21.60	21.30	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	637	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.78	0.70	-6.32	9	364	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	255	0	205	337	3	381.10	26	91.52	CHANGED	us.u.tshhhlllLsLhssshA.hoso+aLoss-hsRhppshsp....shsDLcsAYYulhsLp.LGhpssD..tppsCchlcsslssSS...h-slFYAupuppsLu.Ccls..lss-scshLhAulp-DuolsQ.IYauVuuLssh.....GLsl...supplhpALp.splSK..........E-olhAshhAhpsAutLuptAs.................Lsshl-clEDhssphDElsGshLQFEsGLssTALhVsusa+LuspluspsslptEQllpLsshhhS+pshpohp-sFsllpAhusLSsN+aalPlllhhsGsutl.pcpslL+lpVTsVLupPLotAsVplspA.sSpoopssllppsshs...hcssl...............apLNhhsspPssGhYshslpl...cu-hRhlhsp.spLKVpV..oscVuIsss-lullDpDp.uhusKpp+VsaPsKscsshsADSpQphsLpFQLhDssoGtslsPHQsFV+L+NpcTtQEllFVAEPDSpphYKFELDsutRtp-.FsphSGpYsl.LIVGDAslENshLWNVAcl.LKFs-......c.ssushpupshatPKPEIpHlFRpPEKRPPphVSssFTALlluPLllLhlLWhKLGsNlSNFshSsu....sIlFHlGhuAhLsLhhlaWh+LNMFpTLKYLulLGshTFLsGNRhLuphAs+p	............................................................................................................................................................................................................................................................h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.h.l.....s....t..s...t.....h.p.sHQ.sFlhl......t.......p...p..o.t.-h.a.s.h............p.p......t....t.....hp..hp...l.sh..tph.....p.h......s..s......hph...lll..Gs.ss...hp..s..shh.hpl.........spl.lph.st.............................t...s..s.s.h....t....s..has............p.EIpHlFRts..tKpPPthlS.sFs.......s.h.l.......lssh.hhLhhhW.hp.l..G.......s...N..l.s.p.h....shu......s....................sh.hFa.h.u....hu.uh.h....s....l....h...h...l...a...ahphshFpTL.hhhhlushshlsGs+hLtp.t...............................................................	0	69	112	167
+5646	PF05818	TraT		Enterobacterial TraT complement resistance protein	Moxon SJ	anon	Pfam-B_7686 (release 8.0)	Family	The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between an Escherichia coli and its surroundings [1,2].	28.30	28.30	28.60	29.40	27.90	28.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.37	0.70	-4.92	15	363	2009-09-13 11:01:34	2003-04-07 12:59:11	7	3	289	0	41	252	5	196.60	62	87.08	CHANGED	sL-VpTKMSpTIFL-PVsssc+pVYlpl+NTS...D+sl.slcspltssLpu+G..Y+llssP-cApYhlQsNVLps-Kts.ss.upshLpsGatG...AsuGAAlGsuluuhs..SuuuGuslGhGLAG....GLlGhsusAhV-DlsYpMlTDlQIpE+scssVhsspt....puslKpG......................sSuspsQ.TpocsoshpcY+TRVVosANKsNLchEEApPlLEcpLA+sIAGIF	.....................NL-VpTpMS-TIWL-P....uuc+TVaLQIKNTS.....D.K-h...s...LpuKIssAlpAKG..YpVVouPDcAaYWIQANVLKADKMDLRE..uQG.aLspGYEG...AAsGAA.LGAGIT..uYN...SsSAGA.TLGVG..LAu..........GLlGMAA.D.....AMVEDlNYTMITDVQI.....uERT..+..s.sVpTDN.....VAALRQG...........................TSGuKlQ..TSTETGNpHKYQTRVVSsANKVNLKFEEA+PlLEDQLAKSIANIL............................................................................................	0	9	21	33
+5647	PF05819	NolX		NolX protein	Moxon SJ	anon	Pfam-B_7801 (release 8.0)	Family	This family consists of Rhizobium NolX and Xanthomonas HrpF proteins. The interaction between the plant pathogen Xanthomonas campestris pv. vesicatoria and its host plants is controlled by hrp genes (hypersensitive reaction and pathogenicity), which encode a type III protein secretion system. Among type III-secreted proteins are avirulence proteins, effectors involved in the induction of plant defence reactions. HrpF is dispensable for protein secretion but required for AvrBs3 recognition in planta, is thought to function as a translocator of effector proteins into the host cell [1]. NolX, a soybean cultivar specificity protein, is secreted by a type III secretion system (TTSS) and shows homology to HrpF of the plant pathogen Xanthomonas campestris pv. vesicatoria. It is not known whether NolX functions at the bacterium-plant interface or acts inside the host cell. NolX is expressed in planta only during the early stages of nodule development [2].	25.00	25.00	238.20	32.40	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	624	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-12.97	0.70	-6.16	5	94	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	40	0	19	88	1	324.40	28	76.06	CHANGED	psDSsLhSohDsL.hp.hapLhuulppssp............ssusuhsA.sssuusD.QusQP.p.tT........Fs.tcl+tscAPPshpGS.oVTWpGGTLosoELQIlusLNsHKDphslpatpLpDKINDPsTPPDLKSALQuLpKDPpLF.AIGSQGDG+hGGKIKutDLh-FucpH.QV............................lTWsuGTLspspLEIhShLspH+D.hPlcauplptKINDPuTPPph+tAlpuhpQsPt.hhAhss....................................................h.sPlpupplTWsGGoLopsELpIVAsLNRHKDhCPlpWpsLpsKspDPuhPPDLKAAlpuLQQDPcLFaAIGSQGD.G+CGGKITAKDLS+FS..cHHuQVApYs-pQAcuYsQNYIPSDSs-sscPSVMTENDAMRELYRYSDYLPKcLsh-sFKQIVDGDScTKKCPPQVIAAAQYFlsHP-EWKuL..huGsp-+VuKsDFLQ+ASSuMHLTpsELcTLcTINSHQ-sFFGDGp-lTRDKLAoMucD-SLDPAVR-AAoQLLuDPLLFGLLNNAITGYKT+HuFFsFGGGHTVDSGsISpKDFp+FYssMTuANKTVQpPKTHsAsSsApQcAVADMhMG+ADQPDIKusKKsGGAFp+ulc-hLKh.SKlhDhhSsulSALuuIPllG	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	8	10
+5648	PF05820	DUF845		Baculovirus protein of unknown function (DUF845)	Moxon SJ	anon	Pfam-B_7739 (release 8.0)	Family	This family consists of several highly related Baculovirus proteins of unknown function.	21.20	21.20	24.30	23.20	18.50	15.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.61	0.71	-4.36	20	63	2009-09-11 05:36:17	2003-04-07 12:59:11	6	1	59	0	0	61	0	118.20	55	54.02	CHANGED	lsRlKYDucLLl+YLFDstspt.............ssssNlIKICKV+V+KTsGolLAHYYA+IplSNGYsFEFHPGSQP+TFQslH...o-GplltlhlLCDECCKcEL+sFV-GENsFNlAF+NCEoILCKR	..........................sRlKYDu-LLl+YlFDshss..............spshNVIKlCKV+VKKTsGolLAHYYApIplSNGasFEFHPG..S.QP+TFQslH......oDGhlItlhlhCD-CCKcEL+palcGENsFNlAF+NCESILCKR.....................	0	0	0	0
+5649	PF05821	NDUF_B8	NDUFB8; 	NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)	Moxon SJ	anon	Pfam-B_7830 (release 8.0)	Family	This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits [1].	20.40	20.40	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.26	0.71	-4.62	10	254	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	204	0	156	248	0	145.40	30	83.01	CHANGED	+ulhsupplsp..sssulhhpusRsAuGh.sKDhhPGPYP+TsEERtAAAKKYshRsEDYpPY.PDDGhGY.GDYPKLP.shohccRDPYYsWDaP-LRRNWGEPlHhDhDhYscsRls....ou.sshsWpoMshalhuFlGhM...lhhaahsEsaPsY....pPVusKQYPasshhh..hsDspK.P..VsHYsF	................................................t..........................................................-Ypsh..sD..-shth.GDYPplP.shs.....pppRDPahsWDcsp.RRNaGEPlH...hD...hD...h...a...t..s..phs....pss..s...h..s......hth..hh..h...shluhh.....hhhhhh.hp...h.........pPshs+paPht............................................................................................	0	51	78	121
+5650	PF05822	UMPH-1		Pyrimidine 5'-nucleotidase (UMPH-1)	Moxon SJ	anon	Pfam-B_7840 (release 8.0)	Family	This family consists of several eukaryotic pyrimidine 5'-nucleotidase proteins. P5'N-1, also known as uridine monophosphate hydrolase-1 (UMPH-1), is a member of a large functional group of enzymes, characterised by the ability to dephosphorylate nucleic acids. P5'N-1 catalyses the dephosphorylation of pyrimidine nucleoside monophosphates to the corresponding nucleosides. Deficiencies in this proteins function can lead to several different disorders in humans [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.47	0.70	-5.06	11	291	2012-10-03 04:19:28	2003-04-07 12:59:11	7	4	132	17	172	406	7	214.30	40	78.27	CHANGED	hTLS+ath.NGcRsPTsasIh-ss.p.ls--s+pchppLac+YaPIEIDPpholEEKhPaMlEWWsKoHsLLhpttlp+scIsclV+cscstLRDGhcphFcpLpphslPshIFSAGlGDllEpllRQA.sVhasNlKVVSNaMpFD-sGhLsGFpu.lIHTaNKNsosLc.sopYacpl.............csRsNIILLGDSlGDlsMADGVs......sspsILKIGFLND+VEcpl-+YhcuaDIVLlcDpThDVssuILphIh	....................................................................hTLo+ath.sG.p+s.sosasllcss.thlsp....-hppchhpLhppYaP..IElDPphohcEKhshMhEWasKuHsLl.hpttlp+tpltphVt..c.u....s..hhLR-..G..hcphFppLpppslPlhIFS.AGlGD.l.l.Epll+Q..................t......ss..h...a..............sN.l+lVSNa...MpFs..-s............G..hL.p.......G.......F....cu..p.L.I..HsaN.K....p.p..ss.l....p....ss...t..aa..p..p..l...............p.s.+...sN.....l.lLLG....DShGDlpM..uDGl........sh.pplL+IGFLN..-c...l..-......c.......hcpYh...csaDIVLlpD.p..ohclsptllptl.........................................................................	2	63	82	126
+5651	PF05823	Gp-FAR-1		Nematode fatty acid retinoid binding protein (Gp-FAR-1)	Moxon SJ	anon	Pfam-B_7852 (release 8.0)	Family	Parasitic nematodes produce at least two structurally novel classes of small helix-rich retinol- and fatty-acid-binding proteins that have no counterparts in their plant or animal hosts and thus represent potential targets for new nematicides. Gp-FAR-1 is a member of the nematode-specific fatty-acid- and retinol-binding (FAR) family of proteins but localises to the surface of the organism, placing it in a strategic position for interaction with the host. Gp-FAR-1 functions as a broad-spectrum retinol- and fatty-acid-binding protein, and it is thought that it is involved in the evasion of primary host plant defence systems [1].	25.40	25.40	26.00	26.00	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.70	0.71	-4.26	11	100	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	26	1	68	82	0	146.00	26	76.31	CHANGED	sIPpEaK-LIPpEVs-ahpslTsEEKssLKElh+s.apcaKsE-EhlsALKEKSPsLapKAcKLcshlKpKl-uL.ss-AKAFlpclIApuRpl+sphlsGpKPol-pLKphscshlscYKALos-AK--LpcpFPhlsphhpsEKhQslhsphLs	..........................tpaKphlPt-lhphhpslos--Kthl+...-lhps.....a......t.....p.....a..p.....sp--h.lssLKcKSPpLap+hpcl..pshlcpK.lssL..ss-u+tFlccl........ls..ps+.p.l.hsphhs...Gp.p..s......h....p.c...l....Kph......scphhspacuL..spp..sKp..-Lcps..FPtlsphhpscchp..................................	0	33	42	68
+5652	PF05824	Pro-MCH		Pro-melanin-concentrating hormone (Pro-MCH)	Moxon SJ	anon	Pfam-B_7863 (release 8.0)	Family	This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone [1].	20.60	20.60	20.80	20.90	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.92	0.72	-4.49	2	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	45	0	30	57	0	76.60	70	52.87	CHANGED	h.SppstpKHNFLNHGLsLNLsIKPYLALcGSVAFPAENGVQsTESTQEKREhGDEENSAKFPlGRRDFDhhp...s+hYpsh.pl	.........................+ssGSKHNFLNH.GLPLNLAlK..PYLALKGSVA.FPAENGVQNTESTQEKREhGDEENSAKFPIGRR..D..FDMLRCMLGRVYRPCWQV..........	0	3	5	14
+5653	PF05825	PSP94		Beta-microseminoprotein (PSP-94)	Moxon SJ	anon	Pfam-B_7865 (release 8.0)	Domain	This family consists of the mammalian specific protein beta-microseminoprotein. Prostatic secretory protein of 94 amino acids (PSP94), also called beta-microseminoprotein, is a small, nonglycosylated protein, rich in cysteine residues. It was first isolated as a major protein from human seminal plasma [1]. The exact function of this protein is unknown.	22.00	22.00	22.40	22.00	21.90	21.90	hmmbuild  --amino -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.48	0.72	-3.71	6	122	2012-10-01 23:42:56	2003-04-07 12:59:11	6	1	52	7	63	145	0	86.20	31	74.93	CHANGED	uC.lI.pchlPs-pocECTDLKGNKHPLNShW+TcNCEhCoCccspIoCCThsupPVGYD+++CQ+IFpKEsCpYSVVEKpsPuKTCsVsuWlh	............................................ttChD.h.c.Gp.h.+.slsopWpocsC.pCoC.h.c.s.G.lsC...Csts.tpPlsasp.ppCptlhcpcsCpaplVcKp-PppsCt...................................	0	8	10	18
+5654	PF05826	Phospholip_A2_2	Phospholip_A2; 	Phospholipase A2	Moxon SJ	anon	Pfam-B_7918 (release 8.0)	Family	This family consists of several phospholipase A2 like proteins mostly from insects [1].	20.20	20.20	20.20	20.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.62	0.72	-4.05	23	357	2009-09-11 05:31:23	2003-04-07 12:59:11	7	7	104	1	215	359	0	92.80	33	37.16	CHANGED	lhPGTKWCGsGNhAss.YsDLGstpcsDpCCRsHDpCsphIsu...hps+aGL.pNsshaTh.+CcCDppFpsCLps.ssssh.........uphlGphYFslhps.CathppPp	...................................hPGThWCG.Gs...Ats..hp..-L.G..h...ttsDtCCR...p..H..D.p.Cs.p..h.Its...hps.caul.pNhpha.T.............hp.....HCsCDp.chtpCLpt...hssth.........uphlG.haFs.llph.CFtht..t..............................	2	73	90	162
+5655	PF05827	ATP-synt_S1		Vacuolar ATP synthase subunit S1 (ATP6S1)	Moxon SJ	anon	Pfam-B_8145 (release 8.0)	Family	This family consists of eukaryotic vacuolar ATP synthase subunit S1 proteins [1]. It also contains BIG1 ER integral membrane proteins which are involved in cell wall organisation and biogenesis [2].	37.60	37.60	37.80	37.90	37.50	36.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.70	0.70	-5.09	31	258	2009-09-11 20:52:15	2003-04-07 12:59:11	7	4	174	0	154	240	0	286.90	23	83.89	CHANGED	ssPhllhSspt....h...hssssuphpsssplhshhpphLusCsoctYlhlsQP.......GlpssDFsttps.........hspLpshhptussslthshl........s.lshppLtphlpcpCss.sthlsssstp..ph.th.....csRllhlphs.Lssst......ppRtphLpspDphltpllsplsSsp..YT..............llhso...t....................................httpssptslatt.hsshsts.......hch-hp..................p.........p..pshssp...................................................................spppsssph..hhtcaQ............................aaosGlahullsslhhlslLhhulphlhS	...........................................................................................................................tsPhhhhSspt...............s.ppup.ltos.pl.s..hlp.hLp...s.spsshlhl.Qs.......tlphpDFsthts..........hspLp..ptlt....u.s..sslhhshl........s.hs.hspLtphlp.cphs....s..shhlshts.t...ph.t.........................stllhlchs.hs...ts..........ttpphLpt.s.D......phlsp.lls.pl.upp...YT................slhTuh...s...............................................................p.t..shh...hp..hp.s..............th-hp..........................................h.p...............p....t.tsp............................................................................................................................sspspss.h.......hhpcaQ................................................................................................FFoPG.IaMullsslhhlhIhhhGlphl.p............................................................................................................	0	29	69	121
+5657	PF05829	Adeno_PX	Adenovirus_PX; 	Adenovirus late L2 mu core protein (Protein X)	Moxon SJ	anon	Pfam-B_8179 (release 8.0)	Family	This family consists of several Adenovirus late L2 mu core protein or Protein X sequences.	25.00	25.00	57.40	57.40	18.60	17.60	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.25	0.72	-4.46	18	117	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	86	0	0	63	0	44.30	69	55.74	CHANGED	pppRp+thp+ch+GGF.LPALIPIIAAAIGAlPGIAusAltAupt	...............+RRRRAhpRRLpGGF.LPA.LIPIIAAAIGAIPGIASVAlQASp.h	0	0	0	0
+5658	PF05830	NodZ		Nodulation protein Z (NodZ)	Moxon SJ	anon	Pfam-B_8202 (release 8.0)	Family	The nodulation genes of Rhizobia are regulated by the nodD gene product in response to host-produced flavonoids and appear to encode enzymes involved in the production of a lipo-chitose signal molecule required for infection and nodule formation. NodZ is required for the addition of a 2-O-methylfucose residue to the terminal reducing N-acetylglucosamine of the nodulation signal. This substitution is essential for the biological activity of this molecule. Mutations in nodZ result in defective nodulation. nodZ represents a unique nodulation gene that is not under the control of NodD and yet is essential for the synthesis of an active nodulation signal [1]. 	24.90	24.90	25.00	27.60	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.27	0.70	-5.85	6	136	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	108	5	13	135	8	169.20	59	89.55	CHANGED	pp-RaVlSRRRTGFGDCLWSLAAAWcYApRTGRTLAIDWRGSCYL-pPFoNAFPVFFEPIpDIuGVpVICDDpINphSFPGPFFPsWWNKPSI-ClYRPDEQIFRERDELs-LFQAQ-Ds-ANTVVCDACLMWRCDE-AERpIFcSlpsRsEIpARIDAlYpEHFpGaSlIGVHVRHGNGEDIMDHAPYWADs-lAL+QVCsAIccAKALsHs+PV+VFLCTDSApVlDplSuhFPDLFslPKpFQAcQAGPLHSAsLGl-GGhSALlEMYLLuRCDTVIRFPPTSAFTRYARLhVPRVIEFDLscPuRLllIDcsupphsA	............................................................LAuAWpaAppTGRTLsIDWRGSCYLDpPFoNAFPVFFEPVp-IAGV.VICDDcINphSFPGPFFPsWWN....+PoIDClYRPDEQIFRERDELcpLFQupcDs-ANTVVCDACLMWRCDpEAERpIFRoIKPRsEIQARIDAIYcEHhts...lG..........................................................................................................................................................................................................................................	0	6	10	12
+5659	PF05831	GAGE		GAGE protein	Moxon SJ	anon	Pfam-B_8207 (release 8.0)	Family	This family consists of several GAGE and XAGE proteins which are found exclusively in humans. The function of this family is unknown although they have been implicated in human cancers [1].	20.80	20.80	20.80	20.80	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.48	0.71	-3.94	7	212	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	21	0	48	231	1	97.00	41	61.49	CHANGED	MuaRuRop.R.sRPRRslpssph.lGshl..E.Po-E....pPppEEPPTcSQD.sPuQERE.DpGAuthQssclEAD.QELspsKTGsEsGDGPDsptthLPp.EphKhPEuG.....-tpsQV	............MshRuRop.R.sp..s..R.t..ps.sp..lGshh.pp...o-E.....pspptEPPTcsQs.ssupctp.spGAst.sQs.sc....hEAs.QEh..shsKsGsEptDGPDlpttslPs.EpsKhsEsG..............	1	30	30	30
+5660	PF05832	DUF846		Eukaryotic protein of unknown function (DUF846)	Moxon SJ	anon	Pfam-B_8404 (release 8.0)	Family	This family consists of several of unknown function from a variety of eukaryotic organisms.	20.50	20.50	21.80	20.70	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.90	0.71	-4.48	59	469	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	293	0	302	430	4	135.80	41	65.60	CHANGED	pssHP..h....shhhalhh+hsullhYlh...sshh.......ps.alhpF.llhllLluhDFWhlKNloGR.hLVGLRWWs-ss.......p..cG...............p.spWhFEotsss....t.h.ssh-.............uplFWhslhssshh...............Wllhslhslhphphha...lhlshluhsLshsNhhuah.+C	..................................................................h..tHPlsshFHlhF+suAllhYlh.sshF...........sss.FlhtF..lhhlLLLuhDFWsVKNloGR.lLVGLRWWNplc..............-.-G.................c.SpWlFESpcss.......pph.sts-..................u+lFWluLhssP..ll...............Wllhshh...sl...hph.p.hpW...LhlVhhulsLshsNlhGah+C.....................................	1	111	166	246
+5661	PF05833	FbpA		Fibronectin-binding protein A N-terminus (FbpA)	Moxon SJ	anon	Pfam-B_8577 (release 8.0)	Family	This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host [1]. 	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	455	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.56	0.70	-5.95	114	2820	2012-10-02 21:21:44	2003-04-07 12:59:11	6	21	2261	20	808	2533	427	354.70	22	68.70	CHANGED	DGhhlpullpELppp......LhsuRlpKlhQPppp...-lhlslR.s.tpppht.LLlSupsshsRlplT..pt.shtsPtsPssFsMlLRKaLpGutlhpIcQ.hsh-Rllplplpsc................s-h.Gctthhp........LllElMG+HSNllLl-pps....pIl-ul++ls.p.sp.hRslhPGptYhhPPs.pphsPh..phpp.c.phhph....l............tttls+tLhppapGlSshhucEls....hcss.......p.....h...thpplhpthpphhpplp.............................thpP..phhh.t...........psassl.s...hp....t.......ppasoluphL-paYtp+sppc+lp..p..pppcLp+h...lpsplc+tpcKlpphpcpLppscpu.....-pa+hhGELLpshlatl.ppGhpp.lpl.saas...sp...........................tl....pIsL-sphoPspNAQcYac+YpKhKpuhptlppplcpscpElpYL-sl.splp.............pu.s.p-lp-I+cELhppGYl+.....cppp.cpc+ppp	...............................................................................................sh.htthhpp.lp........lhst+lppl...p.........p.p.............pl.....hh.lp...t..........t.......t...........p..h.......L..ll.sh...........h.sRlpho........p.....t...h.....t...........s...........s.......s.s.........FshhLRKalpsuhlpplpQ.h.......t.-Rllphp.hppt..................................................................h.....hp.........lhlE.lh.G+.uNl.lLs..-........p...........p...........p....p........I.....l-sh..+.+.ls.p...........sp.......hR......lhs.u...Y............h........P........s.t.......t.........t.h.ssh.................phpt.t....thhph.....................h........................p...l......p......h....uh...u..hspch................h.................................................................................t.h.......t......t...h...t...t.hh.t..........................................................................................s...............................................a..h......................ht...........................atsh..sphl-taa..t....t....p.t..........p...p....p....c..lp.....p........ptppl....ch..........lppp...h.p...+.pp+lt.p.h.p..p...p.h.t.t.sppt...............cph.p..hu-ll.....ts.hh...tl...........p....s.........p.p...hpl.....sahp....tp....................................................................................................l..tI.L.s...t.h..ostpNA.ptYa....p....p....h.p....K..h....+p...t.h....p....hl....ppt..lp..ts.p.p.pl.t.a..hpp.h.t..lp................h...s...tl...ht.c.h...........................................................................................................................	0	311	543	709
+5662	PF05834	Lycopene_cycl		Lycopene cyclase protein	Moxon SJ	anon	Pfam-B_8336 (release 8.0)	Family	This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclisation of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare [1,2].  	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.23	0.70	-5.54	20	839	2012-10-10 17:06:42	2003-04-07 12:59:11	7	25	565	0	264	2841	3261	323.20	23	76.95	CHANGED	DllllGuGsAGhtlAtcl.....u+suLpVsLl-suPsh.hssNa.sWsschpDLu......LtsslpasWs.sttVths-pspphhu...huYuplspctLcctlhc+hs.tsushhhsu+Vsplspsss.......hshssGp.....pItuRhVlDupG.ssss......suhpsuhQshhGlElcl-ps.aDssthllMDaR.....spQp......cs.sFlYshPhSssRlhlE-TphussssLsh-sL+p+lhshhcs.hGlplpclhc-EpuhIPl..GGslssh.pc.....shshGssAGhsHPuTGYSlstulutAs....slAp.hls.s..............shuhpshtshasp-RtcpcsFF.hhshhLhlphch-uppphhcpFacLPpthhptFhuu+LolsDhlhluht...h.slssssshh	............................................................................................................DllllG.uG.sAGhslAtpl.......................s..p..h...u...l....p...V.....h.......h.....l...............-....................s...........p.......h................h........s......s......s.....h.......s...........W....s..........t..h..p..s.hs......................................l.t..s..h....l......p.....t...p.......W..........p.....s......s......h........l.....h.....h.........s....s.....t......p...h...t.....hs...................hs.Y.....s.........h...........l....s...........p.p..........t.........L..c..p.......t..h.......h.p......c...s.....h........t......t.u.......l.....p..h......h..p...u..p....V....t...p...l.htpss..........s.hl.h..s.s..s..Gt.......................pl...p.A..phVlDA...sG...hstp...................tsh..s...u....h......Q....h....h.......h.......G..h...h..c........s......p..t............s....a..s.........p....p.......h.h.h...M.D..hR............s..............................ths..s.F.h.....Y.....sh.....P..h.u.....s..s...p....h....h..l....E.....T.....hs..........s....p.s....h...s....h..pt.hpp..thhth.l..p........p....h..........sh..p....h.....p...l....c.........c.E....h...s.h.......lPh.....t..s....s.....h..pt...............hhth.Gssuuhs+Pso..G....Y....h....s....ts.tt.us........hlup..hh.ht..............................t.t....th..h.th...hsh.t..hh..h..p...t....h.h....hhs.......hhhth....tth....hh.p.ha..h...tl.....hh..tFhstt.....t.h.h.................h....................................................................................................................................................................................................................	0	73	187	242
+5663	PF05835	Synaphin		Synaphin protein	Moxon SJ	anon	Pfam-B_8588 (release 8.0)	Family	This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles [1]. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin  transmembrane regions that reside in opposing membranes prior to fusion [2].	21.10	21.10	22.90	22.60	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.95	0.71	-4.02	8	251	2009-09-10 22:35:29	2003-04-07 12:59:11	7	3	90	11	158	207	1	124.40	40	88.74	CHANGED	suFlsKQhlGsQLssVputLGsc.t-EGDs...sAp......EE-tEhpEAlREtEE+RKtKaRKMEpEREpMRQGIRDKYuIKKKEE......pp-spsh.....EGpLGRcKKoPcElAsEAsps----ttpuhhspslcpLss.plp-lhsK	.................hsFhhKphlus.thKshst..h....l....GG-.......--t-s....pAp.................cc.EEhQctlt..pp...c.c.......ERcAcas+hEAER.EphRppI..RDK........YtlpKpEp.......c-sphphA........l..s.c.s..hc.....Ah.stpsp.-.E.E..E.p.p....s.l.s.lp.l.s.slpphhpK..............................................................	0	32	47	91
+5664	PF05836	Chorion_S16		Chorion protein S16	Moxon SJ	anon	Pfam-B_8659 (release 8.0)	Family	This family consists of several examples of the fruit fly specific chorion protein S16.  The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary [1]. 	25.00	25.00	40.00	39.50	23.30	20.20	hmmbuild  --amino -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.64	0.72	-4.16	5	37	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	17	0	8	39	0	107.10	79	78.20	CHANGED	GSGu.YuDVVKssETAEAQAAALTNAAGAAASAAKLDGADWYALNRYGWEQGRPLLuKPYGPLDsLYAAALPPRSFVAEIDPVFKKSsYGGuYG-+olTLNTGAKLAVuAl	.....G.YGASYGDVVKAAETAEAQASALTNAAGAAASAAKLDGADWYALNRYGWEQGRPLLAKPYGPLDpLYAAA.LPPRSFVAEVDPVFKKSpYGGSYGp.pAaLpTsSKLuVVAI..........	0	1	1	5
+5665	PF05837	CENP-H		Centromere protein H (CENP-H)	Moxon SJ	anon	Pfam-B_8705 (release 8.0)	Domain	This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localised in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle [1]. This the C-terminus of the region, which is conserved from fungi to humans.	23.00	23.00	25.30	25.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.10	0.72	-3.86	16	119	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	108	0	88	130	1	106.20	27	46.14	CHANGED	LShthhphppsppsspccLpslchcpLpl+ppsppllpElhphsccpcshcc....s.chpppLcplcuch+po+p+hcshpslhpulllGSGVNWAEDccLpslVLc.p	...........................................................................ls..h.p.tptptsh.ccL.tslchcplplpppspphhtclhplppcpcpppc.....................s.chppplcplcpphctp+pphpsl+plhp.ullluSGVsWAcDtpL+clVLc..........	0	18	34	60
+5666	PF05838	Glyco_hydro_108	DUF847;	Glycosyl hydrolase 108	Moxon SJ, Bateman A, Eberhardt R	anon	Pfam-B_8737 (release 8.0)	Domain	This family acts as a lysozyme (N-acetylmuramidase), EC:3.2.1.17. It contains a conserved EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity [1]. In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion [2,3]. It is frequently found at the N-terminus of proteins containing a C-terminal Pfam:PF09374 domain.	21.20	21.20	21.40	21.60	20.10	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.63	0.72	-3.86	20	820	2012-10-03 00:09:25	2003-04-07 12:59:11	7	13	534	9	151	587	217	85.40	39	42.35	CHANGED	phhsplls+EG............GYsscPcD.GG.......s.....TsaGITttThcshuh............su-l+sLTc-pAh.sIYctcYWp+h+hDpls...tuluhplFDsuVNpG	....................................hhstllucEG............G..YV....sc..PpD.GG............s.......TpaGIT.sThpAhuh......................................tu-h+s..L.T..c..spAh...pIacppYW..psphDpls...tsluhplhDsuVNtG...............	0	33	91	125
+5667	PF05839	Apc13p		Apc13p protein	Wood V	anon	Wood V	Family	The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators Members of this family are components of the anaphase-promoting complex homologous to Apc13p [1].	21.50	21.50	21.80	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.93	0.72	-4.01	7	186	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	177	0	130	157	0	81.00	31	56.67	CHANGED	hDup...hphctsths.lhssapp...DpLP..-Dlh.lP.scL.shp..t--.hhPDpcAshGhp+totpp+..................EssWpDLuLt-Lhppushlss	..............................hDSp....hphpt.hhsll.-tWpp...Dp.LP.h-Dlh...lP...sp..h.................................P-tcts.Gh..s..+to.ppp.........................................E.tWpDLuLppLhpss....s...........................................	0	29	57	98
+5668	PF05840	Phage_GPA		Bacteriophage replication gene A protein (GPA)	Moxon SJ	anon	Pfam-B_8738 (release 8.0)	Family	This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases [1,2,3].	20.90	20.90	21.00	20.90	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.27	0.70	-5.75	11	1036	2012-10-02 18:54:06	2003-04-07 12:59:11	8	4	599	0	93	1026	15	329.10	36	50.68	CHANGED	s-hcchAschAsthpthhpphs-.........p...h.tthhpsYphlAph.shshslp...Pth...........pt...tp.h.sslhRhhs-cWWhcpLpphththhEp..hshs.Vs+ptusYsSpcslp-hRtppptsh-alKuhslcsE-u..pphsLt-hhhtS.SNPthRRsEhMsRl+GhEchAcppGhhulFhTLT.APS+aHAhhcss....+.......W.s.As.Pp..-spcYLssla.shhRAchp+ttlphaGlRVsEPHHD..............GTsHWHhlhFhps..............ccpcplsplhpsa........Alc.DpcEht.cGhh.................psRh+uEhlcspKGoAsG.YlAKYIuKNIDuptltt........chsc-o.u+php-suts..VhuWsphaRIRQFpFaGhsshtsaRELR+hsst	....................................................................phpphus.hus.h......hh.pthh....................t.............p..h..h.p.haphlut...shthp...h....Pha........................tt........p.h.sulhRhhsscWWhcpLhh.phphpEt.hh.A.hs.V............s+..c..............t......osYsSpcslpchRtp+pt.sh-ah+uh.l.s--u...phsL.shh.to.uNP.hRRsEhMsphtGhEhhActcG.h.ulFhTlT.sPS+aH.u....s..h....p.......s..G.....t............psp.................Ws.s...ut...s+....sspcYLs.sha..uhh....Rtthp...c..t..s.......l.........p....h.......aGhRlsEPHH.D..............GTsHWHhhhFh+s.........................................cp.hcpl.....ss.lhcca..........Alc-..D.p.cE..htpss.........................................................tsRF+uEhl......cs........p...+Gs.ssu.YIAKYIuKNlD...ut.u.lst.....................phsc-o....G+sh......p-...o...scp......shuWAphaRlRQFp.h.Gh.s.s.htsaRELRplst.t............................................................	0	3	38	69
+5669	PF05841	Apc15p		Apc15p protein	Wood V	anon	Wood V	Family	The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators Members of this family are components of the anaphase-promoting complex homologous to Apc15p Swiss:O94688 [1].	23.80	23.20	24.40	24.40	23.70	23.10	hmmbuild  --amino -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-3.39	27	114	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	113	0	84	115	0	115.10	25	31.83	CHANGED	sapLWhs...................ssps.pssppppsssttspp.................shhpsss.ss.......tsh..tt..tsssplusLhhcEcthctRcpsItshGaoaI+PhGlsKTMhth+..ccc......tEpEct.tsu	......................................hpLa.s......................s....pstpppt...p.........................h.p.st.ss..t.s...h..tttt......hppspLspLhh-EpthcpRctsIpshGasWl+PhGlsKTMhph+....EEc................tEpcEt.t........................	0	14	38	68
+5670	PF05842	Euplotes_phero		Euplotes octocarinatus mating pheromone protein	Moxon SJ	anon	Pfam-B_8825 (release 8.0)	Family	This family consists of several mating pheromone proteins from Euplotes octocarinatus. Cells of the ten mating types of the ciliate Euplotes octocarinatus communicate by pheromones before they enter conjugation. The pheromones induce homotypic pairing when applied to mating types that do not secrete the same pheromone(s). Heterotypic pairs (i.e., those between cells of different mating types) are formed only when both mating types in a mixture secrete a pheromone that the other does not. The genetics of mating types is based on four codominant mating type alleles, each allele determining production of a different pheromone. The pheromones not only induce pair formation but also attract cells [1].	25.00	25.00	25.80	69.00	23.50	22.60	hmmbuild  --amino -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.24	0.71	-3.81	6	8	2009-09-11 05:26:38	2003-04-07 12:59:11	6	1	1	0	0	9	0	134.00	47	88.96	CHANGED	FKMTSKVNTKLQSQIQSKFQSKNKLASTFtTs.phK..s..-s.....hTGC.sTN..hC...u.sCusTsss.t.C.......sssGQNshDhha.hWhs.C..........hssYssCl..usssYthYSu...CG...C.sshs.ushtD....hhts.Chsa	FKMTSKVNTKLQSQIQSKFQSKNKLASTFQTSSpLKstC..Dshpp..lTGC.sTN.ssC.hpu.sCSuTGsDp-hC.......ssVGQNllDhhFtpWus.C..........aNDYssClpaAspsYshYSusEhCGC.sshp.usapD....hh-uhCss.h	0	0	0	0
+5671	PF05843	Suf		Suppressor of forked protein (Suf)	Moxon SJ	anon	Pfam-B_8911 (release 8.0)	Family	This family consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster Suppressor of forked [Su(f)] protein shares homology with the yeast RNA14 protein and the 77-kDa subunit of human cleavage stimulation factor, which are proteins involved in mRNA 3' end formation. This suggests a role for Su(f) in mRNA 3' end formation in Drosophila. The su(f) gene produces three transcripts; two of them are polyadenylated at the end of the transcription unit, and one is a truncated transcript, polyadenylated in intron 4. It is thought that su(f) plays a role in the regulation of poly(A) site utilisation and an important role of the GU-rich sequence for this regulation to occur [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.91	0.70	-4.67	30	583	2012-10-11 20:01:00	2003-04-07 12:59:11	9	42	284	15	447	699	16	211.40	22	22.92	CHANGED	ohsalthM+shRRspG.......lpuuRplFpcAR.ccsclTaclYlAsALlEaassKDhshAtKIFElGhKhFss-spallcYL-aLIplNDssNsRsLFEpslsp..lssp....................................s+tlap+ahcYESpaG.-LsslhpLEcRhtphFP-.........-splphFscRYph.shsshpsp-ltt.tpphtsp.hh.............................................................spss.+Rslpp.s.p..................................................ststssss.sptt.pssstP............................lPpsIshLLshLPsspha..sus....hhssccLlcllp.psslP	..........................................................................................................................................................................................t...................t.R...hhtps...h...........................p.....pl..hh..t.h..Ahh.....Eahht...pc.....p............AhplFEh..uL....+..p.....asc...p...s....c...h..hh.tYl.-....a.l...h...c.h..s...-.....t.....s..p.................s..R...slF.ERs.l.sp....lsscp.........................................................................p.lap+alpaE....pph....G...cht....slh....p..l..c.p...Rhh..p..h..h.p..................................t..h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	173	257	377
+5672	PF05844	YopD		YopD protein	Moxon SJ	anon	Pfam-B_8937 (release 8.0)	Family	This family consists of several bacterial YopD like proteins. Virulent Yersinia species harbour a common plasmid that encodes essential virulence determinants (Yersinia outer proteins [Yops]), which are regulated by the extracellular stimuli Ca2+ and temperature. YopD is thought to be a possible transmembrane protein and contains an amphipathic alpha-helix in its carboxy terminus [1].  	25.00	25.00	27.20	27.20	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.89	0.70	-5.38	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	76	1	11	45	2	279.90	45	93.75	CHANGED	MIsSDYsNusopsuslTEshsspsptsRossTsHEAAu.sppspuhppsslPtLs+PShshDsctVophsup.L-Soh-MMSLLFcLARpARE.Gl.QRDIENKhlIusQpAQVDEMRpGAKLMIAMAVVSGVMAusSAlhGuFShuKuuKsIKQ-KuLsuNIAGRppLIDsKh-thussGpp..sRttlG+lWpssQsu...DpsALpsLsKcF-pssu+tQlhNTVhQSlGQMuNSAVQVpQGcSQAcAKEDEVpATIuQsEKQKAEDsMSFNsNFMKDlLQLhQQYuQSQNQAWKAAFGVs	..................................................tshh......s.uup.sAhsoEsht.ps-h..+s.sTtppAtsltp..uuht+spsstL.pPppslss...shlpputu-.LsuoLolLhLLhclA+cAREhGl.QRDIENcAsIsAQKsQVsEMpsGApLMIAMAVVSGlhAusS..sVsuuhuhhKssKtlKQEps.LNsNIsGRcpLIDsKhpthustupp.ssRcplG+lW....pspQss...DpstLthhs+cFchpsupspshNushQ...slGQMANSA..lQVcQGhSQAcsKEcEVpAoIAtspKQKAE-sMsasssFMKDVLpLhpQYspScspAh+AAhGVV............................	0	2	4	6
+5673	PF05845	PhnH		Bacterial phosphonate metabolism protein (PhnH)	Moxon SJ	anon	Pfam-B_9057 (release 8.0)	Family	This family consists of several bacterial PhnH sequences which are known to be involved in phosphonate metabolism [1,2].	25.00	25.00	31.70	31.70	19.20	18.40	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.83	73	670	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	649	1	125	414	89	188.20	48	96.50	CHANGED	LtsGFs..........-sVtcuQ....psFRullcAhA+PGpltpl..........t...ss...Pssls.sAsuulhLTLhDt-TPl.......WLsss.hssssltsaLpFHsGuPlsspsppAsFAlhssspshs....sLspashGos-YPDcSsTLllplsuL.........ssG...........................slpLpGPGI..csptpluhs.LPsshhsth...............ptspsh..FPhGlDllLssGs.plhuLPRTT+lcs	................psuFh.PVpDAQ+oFRpLLKAMSEPGlIVsL.............................pphp.pu.......hpPLs.hAosuVLLTLsDsDTPV.......WLuss.ls.s-hVspsLRFHTsAPLVspPcpAsFAls....--uhust...........pLsuhusGTshsPEtuATLIlQVs.SL.........uGGc....................................hLRLoGsGI..t-cRhIAPp.LP-....shlccL...............spRsps..FPLGIDlILTCG-..+LlAlPRTT+VE....................	0	22	65	91
+5674	PF05846	Chordopox_A15		Chordopoxvirus A15 protein	Moxon SJ	anon	Pfam-B_9149 (release 8.0)	Family	This family consists of several Chordopoxvirus A15 like sequences.	21.10	21.10	25.20	24.60	18.70	18.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.05	0.72	-3.93	8	45	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	37	0	0	27	0	90.50	59	96.22	CHANGED	MFVDDsTlIlYs+...WPoCLlssss+alsFPssN..ShTFcsh.hKIsp.shpSVLLlNPShlcLLKICVYl+RhpWcGcIhILFEpcNKPPPFRL	.........................MFVDDNSLIIYST....WPSsLocooG+lIshPcN+..SaTFKEs.FKlD...........E.SlKSILLVNPSuIDLLKIpVYh+RIKWhGcIalLFEpENhPPPFRL..	0	0	0	0
+5675	PF05847	Baculo_LEF-3		Nucleopolyhedrovirus late expression factor 3 (LEF-3)	Moxon SJ, Mistry J, Carstens EB	anon	Pfam-B_9292 (release 8.0)	Family	This family consists of LEF-3 Nucleopolyhedrovirus late expression factor 3 (LEF-3) sequences which are known to be ssDNA-binding proteins [1].  Alkaline nuclease (AN) and LEF-3 may participate in homologous recombination of the baculovirus genome in a manner similar to that of exonuclease (Redalpha) and DNA-binding protein (Redbeta) of the Red-mediated homologous recombination system of bacteriophage lambda [2].\	      LEF-3 is essential for transporting the putative baculovirus helicase protein P143 into the nucleus where they function together during viral DNA replication [3]. LEF-3 and other proteins have been shown to bind to closely linked sites on viral chromatin in vivo, suggesting that they may form part of the baculovirus replisome [3].	25.00	25.00	44.40	74.10	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.20	0.70	-5.54	19	45	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	42	0	0	46	0	347.40	34	89.27	CHANGED	pcctssss.uupsu..phKcshKpVsG.cLlsKshlSlsNchaY..hF+FLlDNpscsYYGstppFpsLh.spsYclsLsa.cp......+l.Isca.cpspsh-psls.VKp..hLptpDF-s--hVsVlAKL+hGFKhlss.ssYKhVFplNhtcstsssp...lhQVEChANhKplusshKs..pshpsts-LhcaahcspsphFsLhRVKC.Qposts...FhNashpshTplEhs.ppsspsh.s.sp.sphs.NISRuNK+lhptpls.phpsEp....pupc+FolpaphtDp.......schhKusaYlcspssppts...ppt...................splpKLphDlsQLsshlpcslhcshIYVssDssss...shNlL.GLTKaDhDs.ppYpsl	.................t..ph.stss.s.sssp..ph+cphKpVsG.pLlsKshhSINNEsaY..hF+FLl-NtscsYYGssppFpshc.spsY-lsLsYscp......+lhIsca.cpspsh-phls.l+c..hlptp-F-s--sVoVlAKhKaGFKhlsu.shYKhVF.lshtss.tssss...ssQVEChuNhK+lssshKs..cslpsps-LhcahhcspsphFsLaRlKCQposss....aKNasltshTplEhs.ppsspsh.stpp.sshs.NISRuNK+lhptpls.plpsEp....pus-RFslpaphp-p..............schlKusaYlcsppspptp....ps...................splpKLpsDlNQLssLIpssll+VhIYVssDssss...NhNVL.GLTKa-lDs.spYpsl.......	0	0	0	0
+5676	PF05848	CtsR		Firmicute transcriptional repressor of class III stress genes (CtsR)	Moxon SJ	anon	Pfam-B_9312 (release 8.0)	Family	This family consists of several Firmicute transcriptional repressor of class III stress genes (CtsR) proteins. CtsR of L. monocytogenes negatively regulates the clpC, clpP and clpE genes belonging to the CtsR regulon [1].	21.90	21.90	22.20	26.70	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.87	0.71	-4.25	48	1181	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1166	2	147	497	0	148.80	48	97.41	CHANGED	Mp.NlSDlIEpYlKplLppop...hlEI+RuElAspFpCVPSQINYVIsTRFThc+GYlVESKRGGGGYIRIhKlphscpt.pllpplhptI.GssIoppsApslIppLhE-plIocREupLhhuslscpsLs.hthstcsplRAclL+uhLppLph	.....+NhSDlIEpYIKplL-pS.s.........hlEIpRuplAspFpCVPSQINYVIpTRFT.p+GYlVESKRGGGGYIRIsK..lchp-.p.p...ph....lppl...l...p..hI.G.p......p.lSQ.ptupslIptLl-cplITcREupLlhus.ls......c......c.....sLu...........pcshlRAplL+plLpplp.h......................................................................................	0	60	102	126
+5677	PF05849	L-fibroin		Fibroin light chain (L-fibroin)	Moxon SJ	anon	Pfam-B_9321 (release 8.0)	Family	This family consists of several moth fibroin light chain (L-fibroin) proteins. Fibroin of the silkworm, Bombyx mori, is secreted into the lumen of posterior silk gland (PSG) from the surrounding PSG cells as a molecular complex consisting of a heavy (H)-chain of approximately 350 kDa, a light (L)-chain of 25 kDa and a P25 of about 27 kDa. The H- and L-chains are disulfide-linked but P25 is associated with the H-L complex by non-covalent force [1].	25.00	25.00	46.80	45.70	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.45	0.70	-5.03	5	31	2009-09-10 22:28:38	2003-04-07 12:59:11	6	1	12	0	2	33	0	225.20	41	90.96	CHANGED	PSVTIsQYS-NEIPPclDNGK..SSulI-RAFDlV.DGGDsNIYILNlQQILNDhAsQGDutSQApAVAQTlAIlu-LSuGIPGDACAAAsVlNAYosuVRSGNsuuhRpALus..aIp+luoNlsLIsQLspN............PsSlRYSsGPuGsCuGGGRSYsFEAAWDuVLusucsh.SSLlNEEYClAKRLYNAFNlRSNNlGAAITAsulssVspVspplhuolsslLRulANGGNAsGAAAsApstLsNAA	..................p-ls.ph-.Gp..spsllspAaplV.Dsu-hsIahLslpphlhD.hAsQsD.ssSQuhAluQThGIluELouslsGDuCutupllsSYsshhp.oG.NpAs..hppAlss..YssplspslstlshLhpN............PstlR.psus.st..uCuGG.GRuYsaEtsWD.hLusus.....t.sLlNEphChu+RLYsuhstRSNsluAAhsAussssspQlhctshspIsshLpssssGssssshstshpptlspu.....................................	0	1	2	2
+5679	PF05851	Lentivirus_VIF		Lentivirus virion infectivity factor (VIF)	Moxon SJ	anon	Pfam-B_9439 (release 8.0)	Family	This family consists of several feline specific Lentivirus virion infectivity factor (VIF) proteins. VIF is essential for productive FIV infection of host target cells in vitro [1].	25.00	25.00	210.60	210.30	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.77	0.70	-5.69	4	25	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	0	0	26	0	235.20	54	97.13	CHANGED	huDEDWQVSRpLFsVLQGGl+sAMLYIosl.schEpt+hK+shKKRLtchEstFIhpLR+AEGI+WSFHTRDYHlGaV+EhVAGoo.PsuLRLYVYISNPLWHppYRPsL.saNpEWPaVNhWIpstFMWDDIEsQpIhpuscsu.GWsPGMlGlVIKAFSCsE+Kh-hTPs.lIRGEIDPpcaCGDCWNLhClRNSPPsoLQRLAMLApG+.scSW+GCCNpRFlSPaRTPsDL.VlQspssaphLaphcL	.........................................M.Ylpc...ppppEpphKpFKc+LuhpEh+WIR+LRhsEGILWSFHTREWHsshV+ELVAGTG...sLKLYCYISpPlW+.RYRPTl.cWNppWPYuNlWlT-tFMW-.IppppIhhsGcVostaPPGaIuLllKAYoCpp+K+DlThtcIIhG-hc.pKWCuDCWsLIllRNTPPhTLQRLAhLALGRKlhsWhCKssaRFhpsRhTPLDpcIl.sssspEsLWh...h........	0	0	0	0
+5680	PF05852	DUF848		Gammaherpesvirus protein of unknown function (DUF848)	Moxon SJ	anon	Pfam-B_9475 (release 8.0)	Family	This family consists of several uncharacterised proteins from the Gammaherpesvirinae.	24.30	24.30	25.10	28.60	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.81	0.71	-4.35	13	27	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	22	0	0	24	0	140.60	32	96.32	CHANGED	pssspK-hltpsLEuslNK+suVSlhDRFGpssuLFcpQappTpcul+stpph+cppclcshlsslcspIpp+p+ElutLpp.hsh+KlschEcLsD+lpEL+--lchEL-slpt......supp-shsupssplc-sIhpWRLEsLPcVPs	.....ssspK-hltpsLEuslNK+suVSlhDRFGtssslFptQappspcul+shpph+cpppltshlsslcpplpppppElshLpt.hsh++lpchEtLp-clt-L+--lphcl-tlp.......ttpp-shssppsp.c-sIhpWRL-pLPpVs...	0	0	0	0
+5681	PF05853	DUF849		Prokaryotic protein of unknown function (DUF849)	Moxon SJ	anon	Pfam-B_9059 (release 8.0)	Family	This family consists of several hypothetical prokaryotic proteins with no known function.	23.20	23.20	23.30	23.20	22.90	23.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.60	0.70	-5.51	131	1281	2012-10-02 01:07:48	2003-04-07 12:59:11	7	8	668	31	447	1226	1571	267.90	29	87.36	CHANGED	+lIITsAlTGuhpT.spsP.tlPlTPcEIAcsAlsAhcAGAullHlHsR...pscsGp...P.op-schapchlstI+pt..s-.hllslT...TGGu................sshsh...c-Rlthltth......pP.EhsoLshGohNFu...........................-hlapNo.s.lcphhpphp.ptGl+PEhEsaDsGc.lhphtphlcc.Gll.c..sPhhlphVh..Glh....uGh.sucscslh...hhhpphsc......shp.W.........oshuhG.+pQhPhsshuhhhGGpV.RVGLEDslahs+GpLA..oNAphVc+ssplscphGtclATPsEARphLuL	..................................................................................................................llITsAlsGuhto.spsP.tlPlTPcElupsAhpuhcAGAullHlH..sR.......sp.s.Gp.................s.ot-sshapchlptI+pt....s....s-.hl.lp.lo...oGuu.......................sths.......ppRh.thlpth........tP-hsoLshGohNas...........................shla.ss.s.lcphhpthp.pt.Gl+sEhEhaDhup..lht.h.tp.h.............hcc..Gll..p.....s..P.h.h.hphlh.......Gl..........sGh..sssspslh......h.h.h..pphsp.............sst.W......................................sshuhG..+pp..h..s..h..sshuhhhGG.p.l.RVGLEDslah...s...c.....G.p....hA.....oNuphVccshplhcth.utplAo.stEARphLtl.................................................................	0	95	238	346
+5682	PF05854	MC1		Non-histone chromosomal protein MC1	Moxon SJ	anon	Pfam-B_9146 (release 8.0)	Family	This family consists of archaeal chromosomal protein MC1 sequences which protect DNA against thermal denaturation [1]. 	20.50	20.50	21.00	20.90	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.16	0.72	-4.02	5	61	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	47	2	35	62	51	93.70	51	83.19	CHANGED	ssKRNFALRDcDGNEhGVFSGKQPRQAALKAANR....Gco-.cAs.s.IRLRERGTKKVHIFcGW+hcVcAPcs+PsWMPscIoKPNVKKpGIEKLE	...........t.sKRNFsLR-pcGpE..huVFoGppPRQAALKAApR........Gpss..tt..t....IRLRE..+GT.cKVHlacGWthp.sAPc..sp.P.s..WMP..s.......cI...sKspVpKpGlE+l-.........................	0	6	26	33
+5684	PF05856	ARPC4		ARP2/3 complex 20 kDa subunit (ARPC4)	Moxon SJ	anon	Pfam-B_9272 (release 8.0)	Family	This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion [1].	22.20	22.20	23.80	23.30	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.93	0.71	-4.87	21	366	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	294	15	220	305	4	158.30	66	89.93	CHANGED	MusslpPYLsAVRpTLpAALCLpsFsSplVERHNKPEVEl........s.........sS..tEL........lLsPlhluRs-pE..+sLIEsSlNSlRlSltlKpu....DEl-cILs+KFs+FhtpRA-s...FhILRRKPlp...............GYDISFLITNh................HoEpMh+pKLVDFIIpFhp-lDKEIS-hKLslNuRARhsAcpaLppF	......................................MotoLRPYLssVRsoLpAALCL...........pNFuSQs..VERH....N+PEVEl........p...................oS...EL........LLpPlhIuRNE..........pE............+VLIEsSINSVRlSItlKQA....DEIE+ILsHKFhRFhh.RAEs...FhILRRKPlc...............GYDISFLITNa................HTEpMhKHKLVDFlIpFME..ElDKEISEMKL.lNARARhVAEpFLp..........................	0	72	122	181
+5685	PF05857	TraX		TraX protein	Moxon SJ	anon	Pfam-B_9375 (release 8.0)	Family	This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits [1,2].	22.10	22.10	22.10	22.50	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.72	0.70	-4.70	27	1213	2012-10-02 17:00:17	2003-04-07 12:59:11	6	5	883	0	132	947	36	217.00	23	91.75	CHANGED	sst-hLKhlAllhMlhDHls...hlhhsshsh................hhh......lGRlAFPlFshllAhNht+.......stsht+hhtRLhhFullupssahhhss...........shhshNllFThhlshhslhhlcptphhthh....................hhhslhhhlshhshs-YshsG.......................lhhslshahhhpp..........................s.hhshslhhhshshhh...........tphhAhhslsllslh...........ststhph.hh+hhFYhaYPsHLhlLhllth	..................................................h..tthlKhlAhl.hMllDHls.....hh....h....h..p.......h...............................hth......................lGRhuhPlFsahhs..sh.+.......T+sppcahhRLhhaul...ls...phs...h.hlhsh..............................s..h.h.t..tNlh.h.o....l..hluhhhlh.h....h....c....t...hp...t...h..tth.........................................hh.hhlhh.hh......h..h....h.s.....sau..hs.u..........................................ll.h...h...hlh...ahhhcp.....................................h..phh...h.hs.s....hhhhhh.shshh............................................stth.h.h.hh.sh.sh.lhhh......................t.tp.u.hp.t.h.h..+.hhFYhFYPsHLhllsllt.h.............................................	1	41	72	102
+5686	PF05858	BIV_Env		Bovine immunodeficiency virus surface protein (SU)	Moxon SJ, Bateman A	anon	Pfam-B_9413 (release 8.0)	Family	The bovine lentivirus also known as the bovine immunodeficiency-like virus (BIV) has conserved and hypervariable regions in the surface envelope gene [1]. This family corresponds to the SU surface protein.	19.90	19.90	20.80	27.80	19.20	19.80	hmmbuild  -o /dev/null HMM SEED	548	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.94	0.70	-6.55	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	9	0	0	73	0	176.00	30	83.22	CHANGED	MDQDLDRsERGEtcGcS-EhR.LlQE-lDcGRLTs+EALpsWh..NNGEIHPWVLsGMhShGVGML..hGVYCplPssllWlLlhQLCIYhulGETSRcLDssSWpWVRuVhIluILGTLoMAGTsLA-ss.u.................ol..NIT..shp...DT-.....Ph......hLhhLhLssILGlLGlIlshRRSNstsILuARDslDWWLSANpEIP.KFshPIILISSPLAGhhGaaVMc+a.chhctGCQhCGSlS.MWGMLL.EIGRhLs+REWsVSRlhVILhISFSWGMahs+..VpAptpHlAMVTSPPGYRIVNDTScAPWFCFSsAPIPoCpSSpWGsKYapEKlNpTlVcQlhcptEtHoRAoWIE.PDLFEEVlYELALLSANuS...........hQV+ssNsTDlCsopNSopssspTM...ThLcLRtplSsTWlsNSSLQFsVHWPaVLlGhNsSp.ostsaNsssWIATNCMDPIpLNcSp.........c-L.KNa.sRsloCVsu..shophs.tpsTLCGaNTsCLpFGp+uhSTNSLlLCQ+Nsh......sNcpFaSLSHSFSKQASt+WILVKVPSYGFVVVNDTtsP	.................................................................huhulGhl..hGlhh.lstshhhhLh.pl.slhhuhGEssRpl.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+5687	PF05859	Mis12		Mis12 protein	Wood V	anon	Wood V	Family	Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length [1]. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants [1]. It has been shown that Mis12  genetically interacts with Mal2, another inner centromere core  complex protein in S. pombe [3].	25.00	25.00	25.20	26.80	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.85	0.71	-4.38	18	240	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	205	0	163	219	0	146.10	27	49.73	CHANGED	hlT-ahGasPhohls-lINAls-hhacshsAhEpslhc+hph.....................Gschhs.........pEIcpGotKlcsLLcsplDctF-KhElalLRslhslP.stLL.cshh+.ht+psphphpp........ppptcs-hphcpt.hp-LEpphplptpLccp	.............................................h.scahuasP......ohls-llNuls-h.lac.shsulEpsLhpp.st.........................................ssp.hs...............-IcpGs.pplcsllcsplD+tF-+aEhasLRslhsl......P...stL.....l....t.shh+.hpphp.phshpt.............................ppptch-.phpph...hpcLppptphpt.Lpp............................................................	0	45	83	128
+5688	PF05860	Haemagg_act		haemagglutination activity domain	Yeats C	anon	Yeats C	Domain	This domain is suggested to be a carbohydrate- dependent haemagglutination activity site ([1]). It is found in a range of haemagglutinins and  haemolysins.	19.60	19.60	19.90	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.44	0.71	-4.36	57	2008	2012-10-02 14:50:22	2003-04-07 12:59:11	8	357	848	3	480	2049	208	124.30	28	7.14	CHANGED	spsssssspsssst....sssshslsshshsssuuhshpsappFsls......psuslh.s..p....................sssspsIlNcV..susssSpIpGhlc.s.t......spAslhlhNPNGIhhsusuplNsushhlsTsssshpts	...................................ss..............ht.......sss.sh..s...hls....Ish.s......ss.u.u.huhspa.p.pFsVs..........ppu...slh...N...p.............................sssupsILNcV......s..u....s..............s...sSp..lpGhlc.lhG.......tpA..pVhlsNP.....sGIsh.susuh.l.N.s.sphsloTupspht..s.........................	0	60	245	377
+5689	PF05861	PhnI		Bacterial phosphonate metabolism protein (PhnI)	Moxon SJ	anon	Pfam-B_9004 (release 8.0)	Family	This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organised in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex [1].	22.70	22.70	22.90	52.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.10	0.70	-5.93	46	678	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	652	0	125	469	126	346.70	67	97.64	CHANGED	MYVAVKGGEcAIpsAapLLsppRRGD....suhspLolsQIppQLsLuVsRVMoEGSLYD.-LAALAlKQApGDhlEAlFLLRAYRTTLPRhuhotPl-TusMtlcRRISAsFKDlPGGQlLGPTaDYTHRLLDFsLhuE...........................................stsPps..................................tscshscs...hP...+Vh-hLppEGLlpsp.........................s....sss.....p.ssDlTREPLsFPssRutRLQsLARGDEGFLLALuYSTQRGYG.cs..HPFsGElRhGpVsVplss.EL.......GFslplG-lplTECp.hVNtFpGsts.....psPpFTRGYGLsFGpsERKAhuMALlDRAL...pstEhsEss..uPAQDpEFVLuHsDNV-AsGFVpHLKLPHYVDFQuEL-LlR+hRpctspt	...........................MYVAVKGGEKAI-AAHtL.-scRRGD....sslPELSVuQIcQQLsLAVDRVMTEGulhDRELAALAlKQAuGD.VEAIFLLRAYRTTLs+lusScPlDTspMRLERRISAsYKDIPGGQLLGPTYDYTHRLLD.FoLLAs.........................GEsPshs..............................................................ss-uptpssP+VhuLLu+pGLhchE..............................p...DsG.......upPsDITRpP.saP....s....oRouRLQpLhRGDEGaLLALAYSTQRGYG.RN..H.PFAGEIRsGhl-VpI....sPEEL.......GFAVslGElhhTECE...M.VNtF.lssss.............EPP+FTRGYGLVFGhSERKAMA..MALVDRAL...pAsEaGEcs..s.uPAQDEEFVLuHuDNVEAuGFVSHLKLPHYVDFQAELELL+RLppEps.pu................	0	22	66	91
+5690	PF05862	IceA2		Helicobacter pylori IceA2 protein	Moxon SJ	anon	Pfam-B_9436 (release 8.0)	Family	This family consists of several Helicobacter pylori specific IceA2 proteins. The function of this family is unknown.	25.00	25.00	57.10	26.30	23.20	16.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.85	0.72	-4.26	2	35	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	20	0	0	32	0	51.90	64	104.66	CHANGED	MAlVlKVVNGKIQEaENG.aKRTYsSNhlsspssGtlVAssTuKGKVEc.........h	......MAlVlKVVNGKIQEYENGsaKRTY.GSNsVsVpluGuIVAssTuKGKVEEYcNG...............	0	0	0	0
+5692	PF05864	Chordopox_RPO7		Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)	Moxon SJ	anon	Pfam-B_9596 (release 8.0)	Family	This family consists of several Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide sequences. DNA-dependent RNA polymerase catalyses the transcription of DNA into RNA.	25.60	25.60	25.70	107.00	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.22	0.72	-3.88	7	45	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	40	0	0	20	0	63.00	78	99.96	CHANGED	MVF.LVCSTCGRDLSEtRY+LlIcctpLKcVLtslpp.CCRLKLSTQIEP.RNLTVpPhLDIN	MVFQLVCSTCG+DIScERY+LII++coLKcVLsoVKNpCCRLKLSTQIEPQRNLTVQPLLDIN...	0	0	0	0
+5693	PF05865	Cypo_polyhedrin		Cypovirus polyhedrin protein	Moxon SJ	anon	Pfam-B_9652 (release 8.0)	Family	This family consists of several Cypovirus polyhedrin protein. Polyhedrin is known to form a crystalline matrix (polyhedra) in infected insect cells [1].	25.00	25.00	499.30	499.10	21.50	17.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.58	0.70	-5.16	2	14	2009-09-11 12:22:05	2003-04-07 12:59:11	6	1	4	3	0	17	0	247.00	95	99.77	CHANGED	MADVAGTSNRDFRGREQRLFNSEQYNYNNSLNGEVSVWVYAYYSDGSVLVINKNSQYKVGISETFKALKEYREGQ+NDSYDEYEVNQSIYYPNGGDA+KFHSNAKPRAIQIIFSPSVNVRTIKMAKGNuVSVPD-YLQRSHPWEATGIKYRKIKRDGEIVGYSHYFELPHEYNSISLAVSGVHKNPSSYNVGSAHNVMDVFQSCD.AL+FCNRYWAELELVNHYISPNAYPYLDINNHSYGVALSN+Q	MADVAGTSNRDFRGREQRLFNSEQYNYNNSLNGEVSVWVYAYYSDGSVLVINKNSQYKVGISETFKALKEYREGQ+NDSYDEYEVNQSIYYPNGGDA+KFHSNAKPRAIQIIFSPSVNVRTIKMAKGNuVSVPD-YLQRSHPWEATGIKYRKIKRDGEIVGYSHYFELPHEYNSISLAVSGVHKNPSSYNVGSAHNVMDVFQSCDLALRFCNRYWAELELVNHYISPNAYPYLDINNHSYGVALSN+Q	0	0	0	0
+5694	PF05866	RusA		Endodeoxyribonuclease RusA	Moxon SJ	anon	Pfam-B_8996 (release 8.0)	Family	This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC [1,2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.94	0.71	-3.70	96	2230	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	1256	7	191	1349	208	112.50	30	86.93	CHANGED	ls.h..........P..psptp.......R.hs.......sthh.s.pcsppa+..ptlthhhtpthhth....h..p...........h..lplphhh.hscph....h...........................DlDNh...hKslhDuls..........th................lapDDsQ..lschpsp.phhspp.....s+ltlplppl	.............................................................sh.sP...sssshh........R.hp..........tsphahs.ptspca.+.p.t.l.t.h...hlppphh...chs.....h..................................lplc.hhh...sscph........p.................................................DLDNl....hKAshDALs...................+u.........ulhh.DDpQ.....lschp.l..h...ht.....hs.s................s+ltlpIpc..........................................	0	62	115	159
+5695	PF05867	DUF851		Protein of unknown function (DUF851)	Moxon SJ, Coggill P	anon	Pfam-B_9669 (release 8.0), Jackhmmer:Q9N4S5	Family	\N	25.00	25.00	25.50	25.50	21.80	21.20	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.63	0.70	-5.13	7	28	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	8	0	28	23	0	198.80	29	48.97	CHANGED	splscspNlEVpsR-VD-sphERVhcKapcEK+pssphsts...lDEKSKlLMDRV.sKKPa.hK..pp-pG.hLhDE.SoFYppsss..KK+.csSh...-DoYsphPKLtDVpKhsspNVascp...GVPFWAVplEPsEEDhpss-.sIoVGoEHlEhY+sKplsLpTI.sTKLhLsElQPLs-LhKRD-lHFsPcLVFSNTlRSLlpspth-....tc.+p...........psKs--ptcst...+lpF-ppcscpa.hYpRsN	...........................pspplplpppplDptphc+lhcKhpppKtp.........s.........lD-Ks+lLhDRl.sKKPa..K.....ppppt.hh..h.D-.o..sFac.p...........pKh.............ptp....-DsYs.hPKLtsVhKhst.psla.pts....s.V.PFWAh..hhc.PsEEDh..............ps.s.-.ssIsVso-HlEhapp+clsLpo.h..ppp.lhhs.atPhs.LhcRDchaFpscllFSNTlRohlpht................p............pt...cptt......plph........h..Y..............................	0	11	15	28
+5696	PF05868	Rotavirus_VP7		Rotavirus major outer capsid protein VP7	Moxon SJ	anon	Pfam-B_9690 (release 8.0)	Family	This family consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer [1].	24.00	24.00	24.10	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.83	0.70	-5.21	3	112	2012-10-01 19:08:57	2003-04-07 12:59:11	6	1	9	0	0	90	0	217.90	65	99.92	CHANGED	MshLLLLVlAAsAsAQLsIlPpocPEICVLaADDathDsNpFsGNFTNIF+oYNSVTLSFaoYcSosYDVIDIISKcDhSSCsILAIDVscuoMDFNTFLQSsNECoKYAAsKlHYlKLPRsEEWFuYSKNLSFCPLSDSLIGlYCDTQLssTYFslScuusYDVTDIPEFTEMGYVFHSND-FYIC+RIS-csWlNYHLFYR-YusSGTVS+pVNWGNVWSGFKTFAQVVYKILDIFFNsKRNlEPRA	...............................lhP.spPElClLaA.sDh..ps..spastNFTpIFcSYNsVTlShhsYsSsNYDV..IDI..LS+hDa..StCp...ILAIDVhcPpM.DFl...oFLQSsNpCSKYuupKIHY.KLsps-EWFVY..SKNLKFCPLSDsLIGhYCDTQlssTYFsLSss.p+.Y-VTDlPEFTphGYsFaS.s.-sFYlC+RloEctWlNhHhFY..R..c.ssSGsluptIsWsNVWoshpTFAQhlYKILDlFFN.spRshEPRA............................	0	0	0	0
+5697	PF05869	Dam		DNA N-6-adenine-methyltransferase (Dam)	Moxon SJ	anon	Pfam-B_9691 (release 8.0)	Family	This family consists of several bacterial and phage DNA N-6-adenine-methyltransferase (Dam) like sequences [1].	27.10	27.10	27.20	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.41	0.71	-4.84	17	691	2009-01-15 18:05:59	2003-04-07 12:59:11	6	13	478	0	57	456	132	166.20	39	83.69	CHANGED	.ptopp.cpstDpWpTPptlFhulsuhFG.....asLDssusccNAhCspaaTtE-NuLppDWspc......Gsh.FhNPPYS+............hp.alc+Ah-ppt+usphVhhlhsusspsh..Wacc....ADcltaIp...............GRluF..s...sstptpstssp...uuslhIac.h..htstthohls+ppLhtpGp.hht.h.tt	....................................s...upp.tc.spDpWpTP..lFtulsh.FG.....FhLDss..u...s....s.c...N...A....h.C..s..t..ahT........t......p...D.......sA......Lsp-.Wsp.+........................GAl.asNPPYSp.................................hc.alc+A..uptp..pt...t.....p..h.Vhh.lhsts.....sV.h..Whpc.h..h.............sDc...lt.h.Ip........................G.RIsF..P.....hsh-.Kpssot.....uuhlhlac.h....t.hhohls+stL.shGt.........t..........................................	0	14	31	43
+5698	PF05870	PA_decarbox		Phenolic acid decarboxylase (PAD)	Moxon SJ	anon	Pfam-B_9737 (release 8.0)	Family	This family consists of several bacterial phenolic acid decarboxylase proteins. Phenolic acids, also called substituted cinnamic acids, are important lignin-related aromatic acids and natural constituents of plant cell walls. These acids (particularly ferulic, p-coumaric, and caffeic acids) bind the complex lignin polymer to the hemicellulose and cellulose in plants. The Phenolic acid decarboxylase (PAD) gene (pad) is transcriptionally regulated by p-coumaric, ferulic, or caffeic acid; these three acids are the three substrates of PAD [1].	24.60	24.60	24.80	29.40	23.80	24.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.05	0.71	-4.76	8	316	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	298	19	83	233	0	152.10	50	91.04	CHANGED	LssFlGKHFIYTYDNGWcYElYlKN-+TIDYRIHSGhVGGRWVKDQcVaIV+LuculYKlSWTEPTGTDVSLshs.s-++lHGsIFFP+WVt-cPE+TVCFQNDHIsLMcpYREtGPTYPphVVsEFAoITalcDsG.sN-sVIAsAP.u-Ls--assshp	......................LpsFlGpHhIYTY....D........NG....WcYEhYlKN-pTlDYRIHuGhVuGRWV.KDQpspIVpl.s.culYKloWTEPTGTsVuLsh..s-+hlHGsIFFP..+..Wlh...-cPEhTVCaQN..-HlslMct.R-th.sYPphVlsEFAsITahtcsGhsN-pVIspsP.sthspDh.ts.h...............................................	0	16	40	61
+5699	PF05871	ESCRT-II	DUF852; 	ESCRT-II complex subunit	Moxon SJ, Wood V, Mistry J	anon	Pfam-B_9765 (release 8.0)	Family	This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB) [1].  This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [1].	21.00	21.00	22.60	22.40	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.63	0.71	-4.25	25	310	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	278	16	218	304	1	140.00	35	58.95	CHANGED	.hYsFPPFFTlQPNssTRppQLssWssLlLsYC+ap+lapLs....l.......h-s...s.............s.sLFpNps..IpR........+Lu.ptlchllsplhcp....u...pAEal..s............ps+o.....................phhIhWRps-EWusllhpWlpcsGppsoVhTlYELspGDpTp.spEFHsL-ps	.................YsFPPFFT......l..........QPs...h.....sTRppQlptWss.......LlLs.Ys....+.pp+hapls.........l.......-t......p......................................s.sLFpNpp....IpR............+Ls.-shphllctltcp.........G...........psEal...c............ps+s............................................................phhIhW+p..s-EWu.sllhpWlpcsG.........ppsoVhTlYELspG.-sTt.....spEaash-..s.......................................................	1	77	121	179
+5700	PF05872	DUF853		Bacterial protein of unknown function (DUF853)	Moxon SJ	anon	Pfam-B_9798 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function. Swiss:Q8YFZ2 is thought to be an ATPase.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.68	0.70	-6.15	9	1311	2012-10-05 12:31:09	2003-04-07 12:59:11	7	6	1266	0	310	1381	194	478.50	52	96.43	CHANGED	pshhssssssp.lhlthphuNRHGLIsGATGTGKTVTLQhLAEuhSsAGVPVFhADVKGDLSGlutsGpss-KlttRhtphGls.sap.pAhPVhhWDlaGc.pGHPlRsTISEMGPLLLuRLLsLNDsQpGVLNlsF+lAD-cGLLLLDLKDLpAlLpal.uDpAcphsspYGNlosASlGAIQRsLLsLEpQGAcpFFGEPALclpDlMRTc.ssGRGsIslLuA-KLhp.sP+LYuTFLLWLLSELFEpLPEVGDsDKPKLVFFFDEAHLLFsDAPKsLl-+VEQVVRLIRSKGVGVYFVTQNPhDlP-sVLuQLGNRlQHALRAaTP+-QKAVKsAAcTFRsNPsFsstpsITpLGsGEALVSsL--KGsPshVpRshlhPPtSRlGPlospERstllpsSPltGhY-pslDR-SAYEhLst.+sutuscttppshsttpt..............................psuhhGshpshthus...pst.R..ushppslsEuhsKSssRolssQluRplVRGlLGoL....+R	.......................................................................................................ts....tpsspplhLh...thANRHG..LIsGATGTGKTV.T.LQ.h....LAEuh...S.ch.G...VP.VFhAD.VKG..DL.o..GlA.p.s...G....s....s....s....-.K....l....h....t....R.hp..p.l.....Gls...-...apspA..PV...hhWDla....GE........pGHPVRAT...................l...........S..-hGPLLLuRLLsL.....N.....DsQpGVLsllF.+lAD...-......p...G.....L..........LLLD........hKDLRAll.......pal........u.......-..s..u..............+..............p........h.p.sp..YG...NlSsA......SlGAIQRuLL....sLEpQGA.s....pFF..G.E.....P.hL-l.pDhM...RTD....ss....G...+GlINlLuA..-+Lhp..tP.+LYu..sF.LLWhLS....EL.a.E.p.L.....P.....EsG.D..h-..K...PK.L..VF.FFDEAH.....L.L...F.......s......D....A......P.......p......s....L.....l.-.....+....l..E...Q....VV.RL.I...RSKGVGVaFVTQNP..tD.lP-sVLuQLGNRVQHALRAFTP+DQKAVKs..AApThRsNP.s..a.D.sppAIspLGsGEALlShL-tK.G.sPosV...-Rshlhs...PpS+hGPlotc.ERsslls.p.SPlh.G+Y-pslDR.ESAYE..hL.pp.p....h.p.ss....s.p...t.....t.p..s....s...s.s.p..t.p.t...........................................................t.ss..hh..s..s.h..p..s.h.hh.u....................s..ts+..........sttpps....l.s...p.......sh...s....K.S.s.sR............plsp........pI....l...RGlLGol........................................................................................................................	0	80	193	258
+5701	PF05873	Mt_ATP-synt_D		ATP synthase D chain, mitochondrial (ATP5H)	Moxon SJ	anon	Pfam-B_9814 (release 8.0)	Family	This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts [1,2]. 	21.30	21.30	21.30	21.30	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.00	0.71	-4.60	5	370	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	281	3	234	361	1	149.30	28	75.57	CHANGED	AuR+lAppoI-WuuLuEplPsNQKAphsulKohsETapoRVusLPEcPPsIDWAYYKpNVs..+uGLVDuFcKKY-ALKlPaP.......E..DKYoupVDAEcKtssKsIupacspScsRIQEYcKcLEKlKshlPaDQMThEDasEsFP-otLD.l+K.saWP........HTPEEpl	............................................Ahp...t.lDWsthsp..p..l..s..s..p..p.t..sths.........uhKp+s.-.phppcl.t.t.L.s-pPssIDauaY+sslt...psulVDchEKp...apuh.K.l.s..hs..............h..sc..httl..-u.E...pp..shpssp..phh..ptsptclpphpcpLpplcs.h.h.PF-phTh--hspshP-ht...............................................................	0	67	113	179
+5702	PF05874	PBAN		Pheromone biosynthesis activating neuropeptide (PBAN)	Moxon SJ	anon	Pfam-B_9874 (release 8.0)	Family	This family consists of several moth pheromone biosynthesis activating neuropeptide (PBAN) sequences. Female moths produce and release species specific sex pheromones to attract males for mating. Pheromone biosynthesis is hormonally regulated by the Pheromone Biosynthesis Activating Neuropeptide (PBAN) which is biosynthesised in the subesophageal ganglion (SOG) [1].  	21.50	21.50	22.40	22.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.91	0.71	-11.46	0.71	-4.95	10	47	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	27	0	11	55	0	136.30	57	89.94	CHANGED	Ma.tophlslhlllsl..sVlAosND..lKD-G.DRGAHSDRuG.LWFGPRLGKRSL+lSoEDNRQAFa+LLEAADALKYYYDQLPY.Ep.QADEPET+VTKKVIFTPKLGRShu...h--+sa-NVEFTPRLGRRLoDDMPATPuDQEhYR.DPEQIDSRT+YFSPRLGR..TMsFSPRLGRELuY-haPsKlRVARSsNKTpST	...........................................................................................................................................KKlIFTPKLGRSlu....c.p.pa-slEFTPRLGRRLu-DMPA..TPuDQ..E..hYp.DPEph-SR.T+YFSPRLGR..TM..sF..SPRLGRELuY...........................	0	5	6	11
+5703	PF05875	Ceramidase	aPHC;	Ceramidase	Moxon SJ	anon	Pfam-B_9877 (release 8.0)	Family	This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.91	0.70	-5.26	41	599	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	310	0	390	567	261	225.10	22	87.94	CHANGED	sGaWG.sTSslDWCE-NYslS...YlAEahNTloNhlFllhuhhuhhpsh+.................pchctpa..hlshlGhhlVGlGShhFHhTLpY...................hhQLLDELsMlassslshashhsphp...................shphphhluhhlhshushlThhahh.hppPslHpsuaullsshllhhshhhhpp..l.s..................................tsc+plhphhhhulslFlhGahhW.lDphhCshhpphRpth..hPhuhhhEhHGWWHlhTGlGsYhhllhhtaLcshhpsp..ppphphha..ht.....slPtlhh	..........................ht..oS.hsa............CE.tsY.hs...hlA.EhhNT..loNhhahh.huhh..s.hh...hhp...........................pt.h.p...th....hlh.hh..h.h.h.lV.G.lGShhFHh.TLp..a...................h.hQ.h.h.DELshl.ashhhhhhh.hhshth.........................................p.p.h.hh.hhhl.hhhs...hhho.hhhhh.....p..s...hhp.p.h...s..ashhshhlhhhshhhh....th.......................................................................htt.phhth...hh...h....uhhh.....ahhuhhhW.hD..phh.Cphhpthp..h.............................hHuh.W.......Hlhhu..hu...sYhhh.hh..hhph.......t.t....h...h...................h.......................................................................................................	0	100	198	301
+5704	PF05876	Terminase_GpA		Phage terminase large subunit (GpA)	Moxon SJ	anon	Pfam-B_9892 (release 8.0)	Family	This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities [1]. 	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.87	0.70	-6.16	53	1654	2012-10-05 12:31:09	2003-04-07 12:59:11	7	10	711	0	162	1653	633	434.80	36	87.54	CHANGED	h.lssc..u..........uupsGpW.......ctspsPYht-lh-slussp..................hccVshhpuAQlGtTp.hhhshluYhIcpsP.ushLhl.PTpstAccascs+lsPhlcsoPsLp........pplus....h.p+cssNolhpKcFs.G.GhlhhhGAsSsssL+spssRhlhhDElDta..stsl.....ssEGcPhsLAcpRspoF...sptKhlhsSTPshcs.....................sopIpptappSDpR.+aaVPCPHCGchp.....lp.app......l+a....sps..........pscsAtahC...cCushIp-ccKst...hh..tt.Gc.....Wlspss.........................................tsscpsuFalsuhYSPh...tsWsplspcalpA.......ps-spt...........LpsFhNTpLGcsW.cpc.u-..th-hppLhsRt..E.sa..............tup......VP........susl.hLTAGlDVQ.pc......RlElplhGWGpstEs.....WllD+tllh....G..............cPsstt..sattLsplLpcpat+s.sGsp.hslsshulDoGs...........................ttTpp.VYsas+pp.t...............ttpVhslKGsss..stshlppsptpsss..ttt.....ultLahVussshKsplh......spLphp...........t.ssGhlHFP.....p.....t.....hsppaacQLsAEphh..+htc.Gh..hhtWp+hp..pRNEALDshVYAhAA...thhhshp.....phcW	......................................su.t.s..a.........thhPa.h...t.hsshusp...................hctVshhtsApsGho...hl.s...hhsY..hl....pc....ts.Lhh....TpttAcpa.+p+lt.hhcs.Pt..lh.........tl..ss...............pc.psNslh.Kp.F...s.h.hhhhGh.usp.hpppshchhhhs-hs..ta.....s.h.......ptEGssh.LuppRhps...........h.lh.SoPt.hch......................sstI..phhp.pusph..+a..ahsCP..H...CGc..........ht...ats........................lph.........................p......................tspsshh.C...............psss.hlttpphp............................p..uh.........altctp.............................................................sc.hsFa.h.s.husa...poW.pllhchhps..................hts.tt..........h+shlNTshG.sa....t..sc...p.ctphl.p+h......h.....................tt.s.VP...............st.s..h..hLsAslDsQ.hp.......Rh.h.lh..Ga....u.tt....Et.....allD+..l.h..t.........................c.sp........h.hhls.t.h.h.p.+.p.a.ht..sstp..htl.thshDsG.G...........................h.sp..sYph.+ppt................hh+lh.hKGsuh..ht.....t..l..h.shsh...........ps.....p.t..................sl.L.h.ltssshKc..l.......sthhhp...................pshs.hh.h+FP...............p..............hs...hppLshEp.....+..c..Gp.................W.pp.t....ttNEAhDhhVYA.Ah...hhh.............................................................................................................................	1	49	97	131
+5706	PF05878	Phyto_Pns9_10		Phytoreovirus nonstructural protein Pns9/Pns10	Moxon SJ	anon	Pfam-B_9947 (release 8.0)	Family	This family consists of the Phytoreovirus nonstructural proteins Pns9 and Pns10. The function of this family is unknown.	20.30	20.30	20.50	20.80	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.75	0.70	-5.42	3	17	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	10	0	1	17	0	296.10	38	94.27	CHANGED	uGKLQDGVAI+RIsDAIshFsNYohG-LlssRchsluTLHslR+NlGLAWPslLhNCalHTSSHhGVMKFlLDIAhShRFGDFTLLGusGssDPFsDlclIaTKoCpsLGhsDs-FLphsDsFuYhhsSFL-cEul+usVDMplGIHNIED+YVhRhESIhcFI+tYYTtSh-DV..lsWLEKL-uAcuGlLuspKSKcQMRuElsplRscIss+IpLYINoacNSap-HaRElAcpYsslWs..losGssAcEsps-AT.....sSuSpsTusuAELs-VsctuDsNEscLp...F+Rc-DAucsAsSchsSLSG-DutpG	..............................................................................GKLQDGlAI+RIsDAIphFppYphG-L.psps.tlspL+slRtslGLAWPslLhNCalHoSSHhGVh+FllDIAhoh+hGsFTlLGusGs.DPFsDlslIaoKoChsLshsDssFLp.s-pFu.hhsuFLptpulputV-MphGlHsIED+YVhRhpsI.chlphYastS.c-l...sWl...KL--ussuhh.tpho+tQMps.ltpsRshIss..cIppYlNpppsS.p-HhRplAppYsp.Ws..lsssssut.spssss...........ssts.sss.suphssss.hsc.s-s......hptp.-ttp.hss.hss..upsu..G..............................	1	1	1	1
+5707	PF05879	RHD3		Root hair defective 3 GTP-binding protein (RHD3)	Moxon SJ	anon	Pfam-B_9973 (release 8.0)	Family	This family consists of several eukaryotic root hair defective 3 like GTP-binding proteins. It has been speculated that the RHD3 protein is a member of a novel class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement [1]. The family also contains the homologous yeast synthetic enhancement of YOP1 (SEY1) protein which is involved in membrane trafficking [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	743	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.42	0.70	-6.61	8	439	2012-10-05 12:31:09	2003-04-07 12:59:11	7	16	244	0	317	440	4	457.00	25	63.95	CHANGED	hGSQSoGKSTLLNHLFGTsFssMDA.spRpQTTKGIWlA+sssl...........cssILVMDVEGTDGRERGEDQD.FERKSALFALAsSEVlIlNMWEHQlGLYQGANMuLLKTVFEVNLpLFhpp.....ss+KoLLhFVIRD+lGsTPLENLpcoLpcDlp+IWsSluKPtuhEsoslsDFFDVpFsALsHK.hpp-pFpppVppLcpRFhpu.............hssGsFts-YH+clPADGFohYA-pIW-pIcsNKDLDLPTQQlLVApaRC-EIusEshpsFhssh....Ep..p.cEsspuuslssLGppLsslhpcslpcYDspASRYccuVYppKRppLcpKlss+lpssaQshLssL+pshl-sFcpulspulcuGp......sFucuVpsptpcslpcFccpscohsl.pssWss.cchhtKLs+DI-spsuplRstcLpcLsschE+plpspLS-sVphhhsssu..................+-sWDslhphFcppscsAlpthpsthsuF....-hs-s.pssphltsL+phSWshlcsKs+EEh..splLh+L+-RF--lFRYDsDGhPRlWpsc-DI-uIa+pARppoLpLlsVLohhRLuDss-sl.ps.hhuhpssssssusp..csl.ss.sslspsphcpltsptpILTcspppslhspFK+ps-hshs-A....KRStlsspTplPsahallLlVLGWNEFMslLRNPLahhlhhlsusssasLa.pLsLhG............PshphlpsshsplhslAcc+hcpshpsscsh+uutphcssusscspps	..................................................hGsQSoGKSTLLNtlFsspFth.st...t.......t.............psT+G..hahsh............................................................hll.hDhEGhcu...E..p.u..c.p.ps....aE+.....p...uLFsl..uh..uclhllNha.........ts.s.hpslhp..hth.h.............................h.hs...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tt................................................................................................................................................	1	98	205	280
+5708	PF05880	Fiji_64_capsid		Fijivirus 64 kDa capsid protein	Moxon SJ	anon	Pfam-B_9976 (release 8.0)	Family	This family consists of several Fijivirus 64 kDa capsid proteins.	25.00	25.00	31.60	31.50	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	561	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.66	0.70	-6.17	5	168	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	0	162	0	486.90	86	99.98	CHANGED	MsDI+LsIAPDLIHsGVPQRLSDTIILNDRPpITLLsHF-sLFcEsNIIKuP+suSspoTVNIYIKp-LL+RLHDRLuoV-ToTLPNIoQl....KEal+sFFpN-lQsIFpsLsNN-lsssFVGVTT+GLSLFAsAKsDAEQIERVQI-TLTEGNlTLKPhSADGlEVILDDsYINlVsKllGh-VpKLI-KCC+ElPAchGIlT..DEVKhhlpTGKLRlDGGYDYNCPSSoTDVT+YGsYDc.FScpMFscLspFaNlSLolVPVuALKslHlh-cELspLDuDKSLLEQsWoAlTSFlESaclKTK..............lKsDDsDchcLscLsssKsNpcusp....AolssoDKsh...........l-WYp+sF.sscT-KulsLsRsElhE.tAcsoSsllc+VKltFushhFEclsssupEKolhV...-TsuG-MTLDpYRuIu-VLNuIWKRGKDlAVcsFDYIKLGlEKA.oHLuslLhKKYNlTlDDIlNFI-KGPSYLAsLsKlsDWsLIAKlIIsSVLPsIIQuVYKoDPSsslMNSlLIo+AsNLI+sD+cRLpcKspucss.s.uNTsc+-sssKlllcKlso	.....MADIRLDIAPDLIHNGVPQRLSDTIILNNRPTITLLSHFNsLFHEpNIVKSPHlASSQTTVNLYIRKHLLTRLHDRLQTVETSTLPNITQL....KEHIpSaFcNEHQPIFQTLTNNNLSDEFLGVTTFGLSLFATSKLDAEQIERVQIETLTEGNVTLKPFSADGLEVILDDSYIGIlGKIsGLEVHKLLDKCCREVPAQMGILT..DEVKLLhRoGKLRIDGGYDFNCPAS.TTDVTHYGGYDQ.aSRQMFE+LNLFaNISLSIIPVSALKTlHlFEKELSsLDADKSLLEQTWSuVuSFlETWpVKoK..............sKs-D.DEYELTuLSsLRpshDGsS....sSSPasDKKF...........I-WY.KTF..uKhEKGSSLR+sElE-KssouTSshsKpVKIHFsVQYFDEhKsNGHEKSVsV....TpKGEMo.L-.YRKIGElLSAIWKRGKuLAsPChDYIKLGVEKA.aHLAPVIMKKYNLTIDDIIpFI-hGPSYLAKLDKIDDWSLIuKLIITSVLPNIIQAVYKTDPSNNVMNSVIISRANNLLKuDRDRLlKKAhoANsSo.SN.SspEHsQKIVLNKVTR..............................	0	0	0	0
+5709	PF05881	CNPase		2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)	Moxon SJ, Mazumder R	anon	Pfam-B_9997 (release 8.0)	Family	This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity [1]. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins [2].	25.00	25.00	25.80	30.30	17.40	17.20	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.56	0.70	-4.95	5	71	2012-10-03 21:31:48	2003-04-07 12:59:11	7	6	44	11	32	67	0	204.90	55	53.52	CHANGED	LPLYFGWFLuKR-E-sLRKTup-FLEpLGNLKAFKK+LptFsuED..K+KlDLlpYFuK.sPslLHCTTKFCDYGKAAGAEEYAQQEVVKKSYoKuFTLoISALFVTPRTsGARVELTEpQLtLWPsDADKE......L.PsDsLPRGSRAHITLGCAA-VEsVQTGIDLLEFVKLQKAG+-GEpVGELsG...GKLoYauNGMWMLuLu+KIEV+oIFSGYYGK.GssVPppGuKKGtplhppCTIl	...........................LPLYFGWFLsKcupEp.l+psu.sFLcpLsshcAFKKc.l..pp.F..ss..ts..ccclDLhpYFs+.....sPGlLHCTTKFCDYG..KAsGA-EYAQp-sVKcS.Y.uKu....FpLolSALFVTP+TsGARVc....LoEpQL....LWPsDsDK............................lsss-sLPtGSRAHlTLGCAusVEsVQTGLDLLEIlp.pKuG...pcGEpVuEl...st..........................GpLh.hGpGRWhLsLs+phclcAlFoGYYGK.tcs.Vsspuspct.t.hppCoI....................	0	8	10	14
+5711	PF05883	Baculo_RING	DUF855; 	Baculovirus U-box/Ring-like domain	Moxon SJ, Bateman A, Dlakic M	anon	Pfam-B_9633 (release 8.0)	Domain	This family consists of several Baculovirus proteins of around 130 residues in length. The function of this family is unknown, but it appears to be related to the U-box and ring finger domain by profile-profile comparison.	21.20	21.20	21.30	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.88	0.71	-4.33	25	57	2012-10-03 15:03:13	2003-04-07 12:59:11	6	1	56	0	0	68	5	133.80	38	95.21	CHANGED	MLlTlph.pD+ctala+hFpchWsp.slECtICh-cIss..cGVVslT-suslNLEKMFHspChcRW..p...ppcpRDPFNRsl+YhFsFPPco.c-spuhL-ch+.uFI...GD-ctD+hasspapR.ssspp.hlDlELDFsphL	.......................MllTlph.pD+ptaha+hFpchWs.ph.shECpICh-cIss..cGVVslo-sutLNL...EKMFHspClc...RW...p.....ppc....sRDPFNRsl+YaFsFPPcohcECpshL-ch+.sFI...GDcctDchapp.apR...lpstp.hlDlELDFpphh........................	0	0	0	0
+5712	PF05884	ZYG-11_interact	DUF856;	Interactor of ZYG-11	Moxon SJ	anon	Pfam-B_9445 (release 8.0)	Family	This family of proteins represents the protein product of the gene W03D8.9 which has been identified as an interactor of ZYG-11.  ZYG-11 is the substrate-recognition subunit for a CUL-2 based complex that regulates cell division and embryonic development [1].	25.00	25.00	25.50	41.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.88	0.70	-5.33	6	31	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	8	0	31	27	0	260.50	29	89.67	CHANGED	hPsssp-G....Psusssss....uNtG.ssstp-AuIshVh+TYupaGpDlpQhsscGlRphspslpp.ossslpphpoohppcosc.............llssLh-ho.PtpluopsIlEhFuhSSlLLllAolSSllGGYlLAPlFGIlIsslGAAIhusLVlPhhusY..LNtcsGSluupRltLllhshsQGVLhGauhsasalsupPFsslTslluSFuYPllshp.sTuRsslLGsssGsSlhhHhslGhlpGuLossYFlLouhYTluAlsLIQ..IAhRsQocss.hphYshlLVuhhlsuKshVYGlFGssc	.........................................................................t....................................................h.t-hpt..........psh+.h..shpp.sssphtphtsphp.pspp................llssl.-.hp..P.thss.slhchF.shoollLlshuluohlGuYlLuPlhslhhsthGAslluslllPshshY...Lst...............c...stuhst..p..Rh.LlhhuhsQGlLhGaulua.shls.u.pPhshlTsllhuFshslls..sp....ss.sRsslLuhssGsuhhhplshGhlpGuLoh.sYhlLosLYohuuhshlQ......l.Ah+.s.hss.s.hphYphlL.....Vs.hlhuKshsYulhGst.t.............	0	9	13	31
+5714	PF05886	Orthopox_F8		Orthopoxvirus F8 protein	Moxon SJ	anon	Pfam-B_9539 (release 8.0)	Family	This family consists of several Orthopoxvirus F8 proteins. The function of this family is unknown.	19.90	19.90	21.90	26.40	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.07	0.72	-4.14	2	53	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	30	0	0	35	0	62.00	73	96.53	CHANGED	MEGSKRKH-SRRPQQEQEQ.RPRTPPSYEEIAKYGHSFNVKRFTNtEMCLKNDYPRIISYNPPPK	..............MEGSKRKH-SRR.QQEQEQ.RPRTPPSYEEIAKYGHSFN.VKRF...T....N.-E...MCLKNDYPRIISYNPPPK...	1	0	0	0
+5715	PF05887	Trypan_PARP	Trypano_PARP; 	Procyclic acidic repetitive protein (PARP)	Moxon SJ	anon	Pfam-B_9554 (release 8.0)	Family	This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated [1].  	40.00	40.00	40.20	40.30	39.90	39.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.30	0.71	-4.37	2	71	2009-09-10 16:45:05	2003-04-07 12:59:11	6	12	35	4	18	70	31	104.10	51	41.22	CHANGED	MAPRSLYLLAlLLFSANLFAGVGFAAAA-tstspslsKGGKGK...............-.-stPE...EstPE.ps..EstPE.ps..EstPE...........EsEPEPEP..........GAATLKSVALPFAlAAAALVAAF	...................................................................................................................tPc...sE..scPEP..E....PEPEPEPEPc..s...sEscPE...psEPEP.EPEPEP...E..PEPEPEPEPEP-Pssu..sh.......................................	0	6	17	17
+5717	PF05889	SLA_LP_auto_ag		Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)	Moxon SJ	anon	Pfam-B_9614 (release 8.0)	Family	This family consists of several eukaryotic and archaeal proteins which are related to the human soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen). Autoantibodies are a hallmark of autoimmune hepatitis, but most are not disease specific. Autoantibodies to soluble liver antigen (SLA) and to liver and pancreas antigen (LP) have been described as disease specific, occurring in about 30% of all patients with autoimmune hepatitis [1]. The function of SLA/LP is unknown, however, it has been suggested that the protein may function as a serine hydroxymethyltransferase and may be an important enzyme in the thus far poorly understood selenocysteine pathway [2]. The archaeal sequences Swiss:Q8TXK0 and Swiss:Q8TYR3 are annotated as being pyridoxal phosphate-dependent enzymes.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.11	0.70	-6.00	5	254	2012-10-02 18:26:03	2003-04-07 12:59:11	8	5	169	15	177	1048	87	327.70	33	79.28	CHANGED	MDTsscsc..ssGlGEREuRVhocLspcslacFsHGlGRSGsLl-sQ.PKAsGuSlhs+LTNcLlpchL+hLGl+tlcssFVVPhATGMSLuLChouhR.++scAKhVIWPhhDcK...SslKAsppAGFchtlVEsll-GDpllTDlssVEctl.cchssEslLsVlSTsosFsPRsPDslcEIAcICu-YDVPHlVNuAYGIQspphhchlppAh+hGRlDAVVpSlDKNFhVPVGGuIIAAhc-salpEIScsYPGRASAsPstclLIoLLuLGssuYtcLh+cQKEsFshLcEpLccLuEchs..............EpllcsP-NPISSAhTlcsls.hpp...ts.spLuucLasR+VTGsRsVpsssshsT..........S+hppY.ssYlslsSAIGl+-EDV-pllcRL-csLc	...............................................................................s.p..t....hthGEREsRhhs.lht...h.............th..hHGlGRSGsl...t.Q.PKAhGuolh.plss.hh.phh+.....hGh........t..h.tt...s.h..hlP...hs.T.G.M.s.l.s.L.sh.s.h.......p...t....+...................p.u...............c.....h.....llas...p....l.....D.pK............os.a.Ku....h..tA...G....h...p.s..h..l....l...p...s...h...h.......p......s......-.......t....l...h...s...s....l...p...s...l..c..ttl....pc...h..G.......p...................s....l..L..s.l.h.o..T.sosF....u....PR................h..s...D..p.............l.....tpluplCtphslPallN......sAYu...l.......Q....s..p....h..h.p........l.p.t.s.....p...h.............GRlDs.hVpShD.KNF........hV.Pl.G...Gul..l..A...u.....s...t..p...h.................l...p...t.....l.......u...p....Y........sGRA........oto........s.................l-........l........h.h....o.L..L.......t...L..Gp.s.u..h.tp.h.lt.pp.h..t..a..h.lpp..p..l..p..chupph.s.......................................c.p.lhps.s.cN.IS....hsh.sh....p....s....h..t.t....tt....................p.th...h.luuhL..apRtl.oG.s.R....l....phts...............t..........sY.lshssslGhptp-l..phhhpplcchh........................................................................................................................................................................................................	0	68	98	148
+5718	PF05890	Ebp2		Eukaryotic rRNA processing protein EBP2	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_9615 (release 8.0)	Family	This family consists of several Eukaryotic rRNA processing protein EBP2 sequences.  Ebp2p is required for the maturation of 25S rRNA and 60S subunit assembly. Ebp2p may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis [1].  This family also plays a role in chromosome segregation [2].	18.80	18.80	19.30	21.20	17.50	15.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.03	0.70	-5.09	28	350	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	297	0	244	346	2	252.80	33	78.17	CHANGED	--sDh-Lp-h..tsphcsshsl.....hpcp+hsINNstuLpssLccIph......t.lsasE+.sls.......us..psh-.plpDhp........................DDhpREluFY+Qu.sAVhpAhspLcchsVshpRPsDYFAEMlKoDEHMpKl+pKLlsEtsuhctSEcAR+tR-lKKFGKpVQstplQcRp+EK+-hl-cIKph+Kp+p..........tt.-phDht..........h--sst.....tsstp+s..............tt..+stss...tKRptKspKFGaGG+K+tpKpNstpSosDhsGFss+h...................+ut...h.................sspRPGKu+R	...............................p-..lpp.h....t.....c.sthsh.....h.tp+.hsl.Ns.ssuLpppLpclph............phsahE+hsls...............................us......pshs.ph.Dhp............................DDh..p..R.EhuFY+Qu.s..AshpuhspLcphs.lPhpRPsDYFAEMsKoDpHMp.Kl+p+..LhpcpsshctuEcs++.RphKKaGKpVQ.sp............pl..p..cR..pc-K+..chl-pl.+ph+Kt+p....................cthDhh..................pcttt.......tpptppt............................ttttpt.tss..........tKRp..tK.spKaGa....G.G+K.+..ht.KpNstt..Sts.D.hsuap.tpth..........................+ut.........................tttR.GKthR..........................................................................	0	85	133	202
+5719	PF05891	Methyltransf_PK	DUF858; Hydroxy-O-Methy;	AdoMet dependent proline di-methyltransferase	Moxon SJ	anon	Pfam-B_9735 (release 8.0)	Family	This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyses the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognise the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified [1]. As with other methyltransferases, this family carries the characteristic GxGxG motif.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.46	0.70	-5.04	7	406	2012-10-10 17:06:42	2003-04-07 12:59:11	7	5	288	3	286	1393	487	201.70	37	81.52	CHANGED	ctcphYpcAlsYWpsVpsoV-GhLGGa...G...plsshDl.GScsFLppLhtc.hs...stppphhALDCGAGIGRlTKslLhchh...........scVDlVEPVppFlspucp.Lup......tpt+ssshassGLQ-aoP-....ts+YDlIWhQWClGHLsDp-LluFhpRCptuLpPsGhIVlKENhsppsh.hhDcpDsSlTRs-shh+plFccuGLpllupchQcGhPc....ELasV+MYALp	..........................................................................................YtcuhpYWp.p...l..suosc...Gh.L...G.....Ga......s......plsph...Dl..pu.Sp...pFLpc.l......h.t....t................................st...s....t.h....p....hALDCGA..GI.G.R....l......T...+p.l...L..h....h..h...........p..p..V......D..l...V..E...s.sp.pFl...p..ps..p..p......ltt.....................t.t.t...+.l....t...p...h..a..s..h.G.L.....Q..-..a..s...P.p........................t.p.Y.Dl.IW.h....Q.W.s..l.GH..L...T..D......p.c.......L..l..p.FLpR.C.+pu.L.........p...............s.....G......h..l....l..l...K...E.....N..h...s..p...........p.....s.....h.............hh.....D........p........p...D.....S......S..V..T....R.....s............p...h..h+p....lhpp..A.GLplltpchQpsh...Pc.........p..lhsVhhaAL.............................................................	0	89	151	227
+5720	PF05892	Tricho_coat		Trichovirus coat protein	Moxon SJ	anon	Pfam-B_9763 (release 8.0)	Family	This family consists of several coat proteins which are specific to the ssRNA positive-strand, no DNA stage viruses such as the Trichovirus and Vitivirus.	25.00	25.00	27.50	26.90	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.38	0.71	-5.09	11	513	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	30	0	0	510	0	176.60	48	77.61	CHANGED	hutptclRstl..........cshLhAths.spcs..ucsGhs+sh.......YLcolFG.IAlhGTSccTpah....................spVs.ltsphupc..hsshuphslpphVsph+saussss-GslpuhThRQlCEPFAppA+-sLlhhtphGsaopLhpKhscsGtKpPpVMFDFNsGLshptLo.tpctsVIpshNpRLFRTEGAKuVFsApuSssEpul-l	.....................................................................ucot..hE........hLcolFuNIAl.GTS-pT.pFh....................-hsspVKshtspc.....sl.GphsLpElVshlKsFpsTSS-sslsshTFRQlCEsFAspARshLVcht.+GlaTNLaspMPcsGpK.PplMFDFspGLsM...hhhs.hspppVIssMs+RLhpTEhAKu..EAp.uSsppsLpl............	0	0	0	0
+5721	PF05893	LuxC		Acyl-CoA reductase (LuxC)	Moxon SJ	anon	Pfam-B_9766 (release 8.0)	Family	This family consists of several bacterial Acyl-CoA reductase (LuxC) proteins. The channelling of fatty acids into the fatty aldehyde substrate for the bacterial bioluminescence reaction is catalysed by a fatty acid reductase multienzyme complex, which channels fatty acids through the thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.27	0.70	-5.75	13	358	2012-10-02 17:28:28	2003-04-07 13:39:30	9	4	316	0	112	2771	1191	335.20	21	69.60	CHANGED	hsslslppllshlhpsupcWpssp.phh..h...htphhuYspphhp..hct...hhhhCp+suLhcll-p-L.up.chLD-al...pts...sY.+AhP+GlshHlluGNVPLlslhSllculLsKNssllKsSSSDPhhsssLlpohh-lDsst.........slscolSVlYa.cuscspLscplh..spADsVlAWGG--Alchlsp.ptsspschlcFGsKhShull-ssA.....slspAsculAcDIChaDQpAChSsQslalp...ssslcEFspcLuptLs+hscllP+up.shsEpAthotpct-.....shhsth..tVh.pspspsWhllhSptt........thhspPL.pRolhl+tlscl.-llphlpps.ps..QTlul.hshpuphthhsp.LuttGVpRIscsGhhshacsGtsHDGhhsLpRLV+a	.....................................................................................................................h........................................................................................................t.....t.l................h........l.......t.............t...h...p..t...l....c..p..ah..........p..t...........t.........p...shsh.uh.sh.Hl.h.u.G.Nl.P.h.l.u..h.a.u.l.l.p.u.l..L.s.tNt.s.l.l..KhSu...s...-...sh..hhshl...h....p....ph....h.p...l..s.s.p.....................l.tp.p..l.s...l..l...a....ttt.........p.t..p..l....s.c..ph......s..p...s..D.....s..l...l.....u...a.G...G...s...p........s...l..c....h.hp....t....hh....s.s...p....s....p...h....l..t.....a....u.s.+.h.S...h..ulls.sps.......php.p.hh.p.t.hA.p.Dlh....h....ac..Q..uCtS...s.p.p.l.al.....t.............p.h.c.th.hp.........t.........l...ht.........t.........h........t....t...h....................h...h..s.....t....t....................s...........t....t....t..s...t..h...t....h.........t.............................h...tt....................h..................t.......t.h.............l....h.....p...........................ps...h......t......sh............l...h....l..s...ph.phh.........l.......t........QT.huh...h.....t.p.h......hs.......hh.hG..s.Rhs..G..........................aDG...h..l.phsp................................................................................................................................................................................	1	42	80	95
+5722	PF05894	Podovirus_Gp16		Podovirus DNA encapsidation protein (Gp16)	Moxon SJ	anon	Pfam-B_9825 (release 8.0)	Family	This family consists of several DNA encapsidation protein (Gp16) sequences from the phi-29-like viruses. Gene product 16 catalyses the in vivo and in vitro genome-encapsidation reaction [1]. 	20.90	20.90	21.40	27.10	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.24	0.70	-5.11	4	17	2012-10-05 12:31:09	2003-04-07 13:56:03	7	1	16	0	0	18	2	330.60	31	93.00	CHANGED	M-KKh.aap.pKlLSYstlhshlI..GARGlGKoYAhKph.lcchlppGcQFlYLRhYKoEltKspNpaFsDlt.paPspcFhVKG....p+hYlc..tchhGahIPLSshQu.KS.uYPNV.TIhFDEFlt..EKs.ssY.PNt....VcshlslhsTV.Rt+...-cVRslChuN...AVolhNPYFlhFth.Ps.NppapspsphllphlssccatsthRcsRFGphIsGhA..Yt-hSlDNpFsss......oclFV.++o+supasFuIhhsstphul.........WlDhppuhhahspu+sPcscpl.aALTscDL..sEsthLlhshpsshhLpphsSsa+KGhL+F-spVlRphhh-lht..hI	.............................................................h.ph.s..h.hhh..Gt+slGKoashp.h.hpchhp.GtphlhlRh.csphtph.ts.ah.sc..l......a.s..hc.VKs............................+chhhD..tKhh..GahhsLSshpph+usuYPpVpsIlaDEFh...-.Kc...NhsYlPNE....sstL.slh-oVhRhR...-cl+sIsLuN...usollNPYFs...aash...s.sKp.hp..tps-sL.l.ph.s.scsapsEp.p....tpLhcGou..YuchSLDNcFhss......p.h.l.+...t.....ptspKhlasIhas.sthlG.V.........Wh..sh.phhhhlspspDPsppsl.h.hp.sDh..ptt...l...hsphhh+hLssthhst.LhFDs..hRhlu.p..................................................................................................................................	0	0	0	0
+5723	PF05895	DUF859		Siphovirus protein of unknown function (DUF859)	Moxon SJ	anon	Pfam-B_9891 (release 8.0)	Family	This family consists of several uncharacterised proteins from the Siphoviruses as well as one bacterial sequence Swiss:Q8K6J6. Some of the members of this family are described as putative minor structural proteins.	20.10	20.10	20.50	20.50	19.60	20.00	hmmbuild  -o /dev/null HMM SEED	624	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-12.95	0.70	-6.26	11	110	2009-01-15 18:05:59	2003-04-07 14:01:24	7	5	86	0	4	104	3	484.90	28	85.00	CHANGED	Ms-FaSNNDRGY+lpLhV-QVuQ.sssNNTSpVRh+LsLhNs....TsTFupYsCsuhVphpGQplsaSupPShlohspolpLIDpTlTlsHsuDGoKThuhsApFsGSGGaSPGTLsIuupsaTLosIPRuSoVS....VusshlGsslTIsIsRpSusFTHslpYp.aGspsGsIuo.slsTSsoWTssl.DhAspIPNSTSGpGTIhVcTYssGshIGop..osshphsl.PsSV+PohoGIoLoDsNosAppllsuss.FlQIhSNl+VsFNGAoGtYGSTI..pGYaAEI........VGtNQosspNGGsLG..hhNasGpsTlRApVoDSRGRpS-sh-spIolLcYFuPuLsFostRsGpsssplslhRpA+IAPLoVNGlQKNpMpLTFclusluossaosDsGsASGsWoshopLssos..AsLuGsYsusKSapVhGpLpDpFoSTsFphsVssEpVVh.......oh-+sG.lGIGKhhE+...GuLDVsGDIYA......ssp.IQQaQLT.NNGts........hpps...Nhl.-sGthhlssSu.sNPs...u...hh...hp.pss.p.hhQTFhuss..hhh...p.sh..ssWtsWpcaupscshsh............hpTsWp.sGhps..shat+sGsshThp.....hph.sst......cshslsshPpchhss...ahhslsu	................................................................................h.h.h...p....s..up.shssNoSpVphphhl...ps.....shoas....h..s......s....h......l.lsGpphp....o...spssh...........s.s..pp.h.L.hstphT.lsHsuDGoK.ohs......h.Aph...ss..s...sGhp...s..sl.s...h...stshsLssIPRuS..o..lo..........ss.sshl.G.s.sholsIs..Rt..SosF...oHsl..pYp...au...ut.pts....l.us..sh.s.T....osoaT.sl....s......hA...splPsusSGssslhlp..TasGus...lGsp.....ohshshsl..Ps..o..hcPohs.u..l.olo-ssshstpllssss..FlQhhSplplsh...ssusG.YGSTI..puYpsEl........sststssssss.u....thG...hhshsGphTlpApVsDSRG+pSsshshplsVltYhsP.th.s.a.sshRsspsss........lp..lhhpspI.u.Plslsu..pKNhh.p.loapss.hss....s.hshsputAu....ass.....pphstss..hsh..u.G.....sassspSa.lhshlpDtFs.s....s.p.h...phs.lss..tpVlh.......shs...psG...lulG...Khh-p.............G..sl-s...G..sh.h......ts..h.....p.h.pLh......................s.h..sG.hh.....ss......spP......................................................................................................................................................................s.............................................................................................................................................	0	0	1	3
+5724	PF05896	NQRA		Na(+)-translocating NADH-quinone reductase subunit A (NQRA)	Moxon SJ	anon	Pfam-B_3622 (release 8.0)	Family	This family consists of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins. The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.35	0.70	-5.20	77	764	2012-10-02 20:27:15	2003-04-07 15:35:01	6	4	731	0	166	1388	819	253.40	47	56.78	CHANGED	hI.pIKKGLDLPIsGsP.p........Q.tIp.susssppVAllGp-YhGh+.PoMhVc.GDpVKtGQsLFpDKKssGVhFTAPuSGpVssIsRGt+RVlpSlVI-l-..s...p........-p.sFppastt..pl...ssLsp-pVpppLlpSGLWTAlRTRPaS+lPss-u.sPpuIFVoAhDTsPLAADspllIspppps......FpsGLslLu+LTsG+.Valspsssss.lPhs.....shssVp.hcpFsGPHPAGLsGTHIHalcPl.uts+sVWplsYQDVIAIG+LFhTGcl	.................................................IpIKKGLDLPIsGtP..p.........Q..sIp...su....slppVAl....lG...--YlGM+..PoMtV+tGDpVKKGQsL.F.E...DK.K.s..PGV.h...F...TuPsSGpVs...s....I.....s......R.....G....t...+....R.....V.....L.....Q....S......V...VIcl-..G...s........-pls..F..s.c..a.s..s.p...pL....usLsp-pV+...ppLlpSGL........W....T....A....l.R.T.R..P...F....S...K...l....P...s....s....-...u...pP....p.....u...I...F.V..o.AhDTNP.L.AADPpllIppp.p..cs...........FpsGL.s.l.L...o.+...L..T.c..u...K...V..al.C..p...s.....s...s..s.......s...lPtp.........shss...Vp.....hcpF.sGPHPAGLsGTHIHFl..pPV..uts+s.....VWpI...sYQD.VIAIG+LFhTGcL...................................................................................................................	1	45	95	138
+5727	PF05899	Cupin_3	DUF861; 	Protein of unknown function (DUF861)	Moxon SJ	anon	Pfam-B_2000 (release 8.0)	Family	This family consists of several proteins which seem to be specific to plants and bacteria. The function of this family is unknown.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.32	0.72	-4.59	33	1583	2012-10-10 13:59:34	2003-05-01 16:21:48	7	10	1032	14	492	2347	591	76.00	27	46.50	CHANGED	tstsushptGlWpsoPGcaphphsp.pEhs....allpGclpls...........s-....sGps......hplpsGDhhhhPtGh......pusWclt-s.l+....KtY	...............................h.t.ptshhhshac....s.ss.G...p.............h....p....h....h....h....s...p....t...E..hh...........al..lpGplpl.s...........st.......sGcs......h.p.lssGDhhhhPsGh.........pssWcs.th.h+Kha.......................................	0	106	251	370
+5729	PF05901	Excalibur		Excalibur calcium-binding domain	Moxon SJ	anon	Reference 1	Domain	Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognised and the evolution of EF-hand-like domains is probably more complex than previously appreciated [1].	21.00	21.00	21.10	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.86	0.72	-3.61	68	1070	2009-01-15 18:05:59	2003-05-01 16:38:01	6	44	876	0	230	825	85	37.90	39	17.10	CHANGED	shpsCsphpusstAthaht..................psshss.....cL...........DtDsDGluCE	.............................................atsCpphpss.s.us.lhts.................................cPuYss...........+L................DRD..p...DGlACE.....	0	63	151	202
+5730	PF05902	4_1_CTD		4.1 protein C-terminal domain (CTD)	Moxon SJ	anon	Reference 1	Domain	At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although  such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates [1]. 	25.00	25.00	26.60	26.60	23.90	18.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.67	0.71	-4.03	9	519	2009-01-15 18:05:59	2003-05-01 16:43:59	8	12	80	0	154	372	0	107.90	60	12.64	CHANGED	ts-Isocchslstspspshs.pshph..ssss.-sslLlospTITuEohSTTTTTHlT....K........................TVKGGlSETRIEKRIVITGDsDlDHDQALAQAI+EAKEQHPDMSVT+VVVH+ETEl	.......................................................................................p.....hp-sPllpTETKTI..TYE....us........ph...D.s.s.....s.....sh-...sGV..LhoAQT.ITSE.T....s.S....TT.TTTHIT.....K........................TVKGGISETR..I..EKRIVITGDuD.ID.HD.Q....A.....LAQA.IKEAKEQHPDMSVTKVVVHpETEl.....................	0	21	33	77
+5731	PF05903	Peptidase_C97	DUF862;	PPPDE putative peptidase domain	Bateman A	anon	L. Iyer	Domain	The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p) [1].	29.20	29.20	29.20	29.40	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.12	0.71	-4.43	41	818	2009-01-15 18:05:59	2003-05-02 09:40:48	9	22	288	2	549	790	22	135.60	31	40.10	CHANGED	t.VhLpVYDLo...p....................shhLGh...........Gl..aHoul........laGp.Eahauu..........sGlh..................pspPtp.....p.G.p.pcsl......lGpTclsppthcpal...pplup..c.....apussYcLls+NCNcFosclsphLsGcpI.....PsalpcLsphshphshsptl...hshhh	...................................................h..VhL.VYDls......p............................hhhlGh................Gl..aH.oul..................laGh.EahaGu............sGlh.........................pspPtp............s.sh.phccsl.............hlGp..Tp..hstp..phpphl.....cplup...p.........apussYcLlp+NCNcFosplsp.h.L..s...G.......p.......t...I..............Ppa.lscLsphs.....hht.h........................................................	0	198	333	456
+5732	PF05904	DUF863		Plant protein of unknown function (DUF863)	Moxon SJ	anon	Pfam-B_7732 (release 8.0)	Family	This family consists of a number of hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	25.00	25.00	32.60	32.60	18.90	21.50	hmmbuild  -o /dev/null HMM SEED	805	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.64	0.70	-6.27	7	79	2009-01-15 18:05:59	2003-05-02 10:12:57	6	3	15	0	56	66	0	465.10	22	72.35	CHANGED	hhs..shSh...........ctuostpssl...shh.tpsspV.pspss........KhR++MlDLQLPADcYlDs-ptps.Gpp....................cphpssspp....p.ppssssss....lsl....psopGluDLsEP...............Vpsppspshu..hohDhhu+hsss.ucspsptlphs...............s............................EssptKsss+ssu....stp.ls.ssp..p.h.spu.p........P.....ps..phthhcERophshE....hppts.th.hps...l-tusssphPp.s..h.p.......s..h..hsH..uu....osuhsp+s...hssQppPhh........................phcosupsssuhssp..shspNthhpG.SssStpp.h.hsuhs.p..s.s.tt.sspt.hhp....................shp.s.ps...................tpppp.sslPWLp..t...p....................................t.hsLpss.........................ps..tssh..hclp.ssspppppIhh..h.tp..hs.....cp.s.......uhhhust.pclpp.h....hsLshN.ss-hsh........s...ptccstct...AssRshIDLN..ssoEDp.Epsshsup.th......psKh.h.IslEs..s.Es...-.p..........pcps........t.ssss.sEhh+hAAEuIVAI.....spcs.ssuSs.s-h..pp..LpWFs-hhtoptp-h.pp.-h..t...........sssphD.FEuhTLpLpETpt-EYhscPhsP..E..ph-c.os....s.s+PRRGpARRGRp+RDFQ+DILPGLsSLSRHEVoEDlQhhsGlh+usshsWp.SGhs+....hpussRGR.....hpss..sp..........sssssshsp..ss............DpulsGWGpsTRRsRRpRCP	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t....AAp.ll.h.............hp..sp.......l.hFsp.h..............p....t...h.....t.ptt.......sttshD.FEthTLpLpEhp.--hhshs.hs..t..p.cp.........p+.hpsphRRuRp.h.+DFQ+-ILPuLsSLSRpElsEDlphhtshhpupthphp.os.h.sc.ts..tsts.R.s+.....................................................................................................................................	0	6	31	43
+5734	PF05906	DUF865		Herpesvirus-7 repeat of unknown function (DUF865)	Moxon SJ	anon	Pfam-B_9911 (release 8.0)	Repeat	This family consists of a series of 12 repeats of 35 amino acids in length which are found exclusively in Herpesvirus-7. The function of this family is unknown.	20.10	20.10	24.10	87.20	17.70	16.30	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.70	0.72	-4.37	2	12	2009-01-15 18:05:59	2003-05-02 11:12:20	6	1	1	0	0	12	0	35.00	95	98.36	CHANGED	MGSHPFRQEpPpPHNPLTFKPVKTTGTAVsFSAGF	MuSHPFRQERPQPHNPLTFKPVKTTGTAVAFSAGF	1	0	0	0
+5735	PF05907	DUF866		Eukaryotic protein of unknown function (DUF866)	Moxon SJ	anon	Pfam-B_8299 (release 8.0)	Family	This family consists of a number of hypothetical eukaryotic proteins of unknown function with an average length of around 165 residues.	22.90	22.90	23.20	23.10	22.10	22.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.17	0.71	-4.74	9	382	2009-01-15 18:05:59	2003-05-02 11:19:09	8	12	290	2	254	373	4	144.50	32	84.37	CHANGED	MV+huLplpAsLENlpsLpPst....psa.aahKlKCsNCGElo-Khptlohs-pVsh.uG+usu.Nhs.KCKhCuREsSIsIlsushpshsh-DS..tchpsIssF-CRGhEPl-FtPpssWtApusEoGo.Fc-IDLpEt.-Ws-YDEKspsoVuIhphcppFp...hhK	..............................hhL.lpAp.L.cslsplpP.s.........psa...ahh+lpC.ssCtEhptphhhl...sh...-..ph..th....u...u+......G.p............A..shl.K........C.KhC.t.................+-sShs..l.....h...s...........s.....p....h..............p.....s....hs..h.c......ss.....................tchpsl...ltF-CRG.lE.s-FpP............p......s............t..ahspuh.oGshF..p....sl.cL..p........-t....-WhDYDEKstppVulhclphph....h....................................................................................	0	80	135	205
+5736	PF05908	DUF867		Protein of unknown function (DUF867)	Moxon SJ	anon	Pfam-B_7778 (release 8.0)	Family	This family consists of a number of bacterial and phage proteins with no known function and is present in Bacillus species and the Lambda-like viruses.	27.10	27.10	27.60	30.10	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.19	0.71	-5.22	37	384	2009-01-15 18:05:59	2003-05-02 11:22:44	6	3	199	2	70	273	50	188.60	34	69.65	CHANGED	Ypsap-Lppspp.tpDapIphpph.s.oplllhA.HGGuIEsGTSElscthu.....ssaShYlFEGl+tps.NpsLHlTSs+FD...EPhslphlpppchslolHGYtspp.......ppshlGGpDcthuctlscpLpptGFss....tstsscluGhpssNIsN+sp......sutGVQLElSsu.RcshFcshshppcsht.....spshhcalpul	....................atshs-Ltpppt.....DapIcsppp.s.SplhllA.HGGGIEsGTo...ElA.ctlA.................phssashYhFcGl+pp.......s...N..p.pLHlTSo+F...D....-Phhhchlc.p.p..phslSlHGhsusc.......phlhlGG.p.....Dcp.L.tptlscpLpp.t.....GasV..............tssP.pcluGhpssNlsN+sc......p.s..sGlQLELostlRcthFcshphspcshpp....s.hhh.pasp..................	0	14	34	60
+5738	PF05910	DUF868		Plant protein of unknown function (DUF868)	Moxon SJ	anon	Pfam-B_8013 (release 8.0)	Family	This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	20.60	20.60	22.40	21.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.14	0.70	-4.94	19	260	2009-01-15 18:05:59	2003-05-02 11:39:36	7	9	24	0	155	257	0	251.40	32	81.23	CHANGED	tsuspssVTslYpscl..ss+.tl.lplTWo+shh.....ups.Lolslssss................................pshs+hsh.pPhhFt+++GS+....................sh.pssusp...l..-laWDLosAKF...uu...uPEPlsGFY.VAVVsssEllLLLG......Dhc+-sh++stss.......sushlu++E+la..........G.p+hasTKApF..t-sGppH-lsI-C.......sssG.....tp....s.plhlslDuKhVlQV++LpW+FRGNpTlhl.DGhsV-lhWDVHsWLF..........u..suss...p..........AVFhF+sp....tu.-p.....................phh.pttstsssp...p....................t.sFsLllhAaKh	.........................................s...pshsoslYpspl........ttt.th.lsloW..s+shh......spu..Lslslp..sss.......................................p..h+hp.h..pP.hh.h..h+++.....GoK......................ph...pst.us.p......l..claWDLssA+F......uu...uPEPhss.aY.Vul.VsctEhsLlLG.........Dhpc..-uh.......++ptst......s.h...psshlu++E+lh...........G.p+hasT+ApF...t-.pGp.H.-lsI-s......................tttu............t-....s..phhlplDuch.llpV++LpWKFRGNpsl....hl..ssh.VcVhWDVHsWLF...................................s..ss.s.......p...........AlFhF+st........s.pt..................................................................p.................................................................tFsLhl.Ah+.............................................................................................	0	12	87	123
+5739	PF05911	DUF869		Plant protein of unknown function (DUF869)	Moxon SJ	anon	Pfam-B_8094 (release 8.0)	Family	This family consists of a number of sequences found in Arabidopsis thaliana, Oryza sativa and Lycopersicon esculentum (Tomato). The function of this family is unknown.  	40.00	40.00	45.50	41.20	39.80	37.50	hmmbuild  -o /dev/null HMM SEED	769	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.73	0.70	-13.58	0.70	-6.30	12	276	2009-01-15 18:05:59	2003-05-02 11:43:02	6	6	18	0	199	290	0	328.00	19	77.52	CHANGED	KEsLltQHuKVAEEAlsGWEKA-sEshuLKppL-sss.tphshE-RsuHLDuALKECh+QlRps+EEpEpplpDshtppopph-phchpLEt+lt-hppclhcssuENssLoc.Lpt+pphl.clscp+s.h-sphpsLpspL-usEKE.soL+YEl+slpKELEIRscE+shSh+SA-sAsKQHLEslKKIuKLEAECQRLRshVRK+LPGPAAlApM+.EV-th..upshs-sRppts.u..p....................................pp...hpccs..hht+hhthE-EsKhL+-uLuc+ssELQhScNhhAcpsuKLp.h-sph.................................t.hsEpt..-DthSsupSWA.suLlSELpph.KpcKt.spuphtpssu.clpLMDDFLEMEKLAs...lsstussssppsspstsscppsthst..pppt..ps.................................p........t+hltplp..plLccIctphsphppupspsppp.p...................................sh.pp.pshpp..hs..pcLpshluph.....pchht.Lpp.hphhp-...tpsshpchlp-hshshphhlsp.psLp-...........ttplp..h.h...................................................................pchEphcspptphth.........p..p.ph.....pE.EpplpplpspLp.tspcSpshsEsplcshspp.culc.+t.clc.chp.hp.plppL-sELpcE+tspp-thsKsp-lcpclp+.ppptsttph.......cp-h+h+Q-pEIuuAAEKLAECQETIhsLG+QLpoLp.s.p-thlso	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t................................................................................	0	29	121	163
+5740	PF05912	DUF870		Caenorhabditis elegans protein of unknown function (DUF870)	Moxon SJ	anon	Pfam-B_8400 (release 8.0)	Family	This family consists of a number of hypothetical proteins which seem to be specific to Caenorhabditis elegans. The function of this family is unknown.	27.10	27.10	27.20	27.50	26.60	27.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.63	0.71	-4.27	6	55	2009-01-15 18:05:59	2003-05-02 11:45:43	6	4	5	0	55	53	0	106.80	24	63.69	CHANGED	pFpAtIcCslstsaWCG-LYllEcDshh....................................................................HDlLppcKFCTSEppKph+FTVsPtsDF.oscaEhsYhhNHNCTADGcshCVKPpcopcVssast.+oVcFsI-AtsNGcsppCcsP	............t..th.lpCs.........t.....hWCuplhlaE.Dh.h.h...........................cDll.t.p.p.pFCo..s.pt.p....c...p...a.ca..s.h...p...s......suD....h..o..................spYEhshhlpHNCos.sG..p.h....h..Cl.p...p...h.s.h.....t.h....................................................	0	15	19	55
+5741	PF05913	DUF871		Bacterial protein of unknown function (DUF871)	Moxon SJ	anon	Pfam-B_8510 (release 8.0)	Family	This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.	21.50	21.50	21.50	21.50	20.80	21.40	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.62	48	1290	2012-10-02 15:38:38	2003-05-02 11:49:29	6	2	773	2	132	806	4	344.50	34	98.71	CHANGED	tLGlSlY.scs.thccscpYlchupphGFsclFTSLh.sc...sst.cphhpphpclhphApphshclhlDlsPplhppLsloapsLshhcc.hGlsGlRlDhGFospphAphops..slcIpLNhSs...........spchlcplhshpsshsplhusHNFYP+..TGLuhcaFhcpschh+chG..l.couAFlsup.ssppGP..lh-...GLPTLEpHRths.hspspcLhtsshIDclllGsshsScc-Lcpluph.pcphhpLclp...shs-h-tcll.cphHppRsDsuc.VlRSspoRh.....hht.ppsh.sp.ss.s.hp+GslsIDNptYG+YpGElQIshp-hssct+sNVVGclhc--l.LLchIcPhpcFphhtp	.....................hlGlSlY.pcs....hpcsctYlchutchGFpplFTS.Lh.sp....ccp.cphhpcapcllshApphshclllDlsPslhcpLshoap......s......L.p...........a.pc.hGhhGlRlDhGho.s..pp.uthotp..slK.IpLNhSs...........spphl.cslhshps..shs...p..LhuCHNFYP+..TGLuh-aF.cpschh+chu..l.p.o.hAFlsup..s.sph.G..P...lpc...GLPTLEpHRph..p...hst..uccLht..oshl..D-VlIGsshsSccplcplup..h..pcp..hhpLclp....tths-hppphl.h.p.p.hH.........h.RsDhsc.llRSs......poRh...................hhp..ppsh.....sp..po...t.t.hp+GslsIDNptaG+YpGElQIslp-..hss.cs.+sNVVGpIhc--l.LLshlp.sh.ppFphh.p................	0	42	78	105
+5742	PF05914	RIB43A		RIB43A	Moxon SJ	anon	Pfam-B_8571 (release 8.0)	Family	This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialised set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterised in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialised protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organising their three-dimensional structure. Human RIB43A homologues could represent a structural requirement in centriole replication in dividing cells [1].	25.00	25.00	32.00	25.30	24.50	20.20	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.17	0.70	-5.83	13	202	2009-09-10 21:00:25	2003-05-02 12:53:47	7	4	109	0	131	193	4	312.80	31	95.74	CHANGED	Ma+lcls...D.cEstAlE+RRstEpERpsRIFNu+sRshGVDlcALcpQVpE+KhpEpsE+p+-cuYsspphp.DclsthhccEpcpcp+pLs+clppFRppaQ+hEspREFDL..DP-sl+K.shPsRluD-Dsp...hGsSShQpFpGEDLppssR++hQpEQ.RpWlcpQhpE+ppActpc+pADplh-phthphDpRAtcLuphEcpsRptlppAspcaNcA.Accpptccppc+pp-p--NhAEIpNploSDhLTENPsVA....pSshuPaRVlstpWKGMoPcQlpsIRcsQ-pQhpEKccpRppEpth-tpWpppphphuRAhhhLEcpccRhp+ph+cpLsphNppLAtEQ..cAppcaLpcplYsNpPTspYapQFNToSR	.........................-.....tltt++ph-.pRppRhhss+.RhhGlDhpsLptQlt-+c.pcthEp.tcptthstp.ht.cplhthh-pctpcpp+tlp+tl.ppap.pp.h.Q.p.cppREaDL..DPtthp....................K.thPsc.us..sDsp....u.SuhQh.....F.GEDLshtpRp+hQpcQ.RtWh.pQ.pEppptctpcctt.-.thhsptphph.-ppttcltph-ppsRpthttshtpaNps.....Atcptpccppc+pp-pcsshsEItp.lp.uD.hLoE.sPp..A....tst..hu...s.pR..ll..s...paKGMo.-Qhptlpp.hQppQhp-p...tph.cp..t-pth-tpWp.ppphp.s+shh.h-cpppc.ppph.pctls...p.N..pLApcQ..ptppp.h.t.lh.p.NtsstpaatQFspssR.........................	0	54	63	92
+5743	PF05915	DUF872		Eukaryotic protein of unknown function (DUF872)	Moxon SJ	anon	Pfam-B_8741 (release 8.0)	Family	This family consists of several uncharacterised eukaryotic proteins. The function of this family is unknown.	22.10	22.10	22.10	22.20	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.77	0.71	-4.22	13	281	2009-01-15 18:05:59	2003-05-02 12:57:19	7	3	132	0	171	286	2	107.10	29	77.02	CHANGED	Y..psLss.D-D.............hcs...........pFspssss.p+ss...............h+sIhhAhhLLllGshLllhGhhlhss..t.ussspuhshhlhGhlhFlPGhYastlhahAh+Gh+GasF.plPsF	....................................................................................................................ht.........p.................................hKsIhlAhhLhllGs...h.LlllGshlhss....h.ht.....sssspuh.shhllGhLhFlPG.hYalh.lhYhA.h+Gh+GaoasplP.a....................	0	52	86	126
+5744	PF05916	Sld5	DUF873; 	GINS complex protein	Moxon SJ, Studholme DJ	anon	Pfam-B_8759 (release 8.0)	Family	The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3].  It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family.  The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.75	0.72	-3.76	176	1118	2010-01-07 10:55:00	2003-05-02 13:00:16	6	12	372	22	798	1076	14	113.40	15	50.89	CHANGED	sclPhahut..Lhc....................pshspl..p..phhshc..hpthptp...............................tps.t..hplt...................................................................hthsph..........................p.+p.........................hlps..hh....ctRhtKlpphshph.......................................ttstthh..spLottEh	..............................................................................................................................................plPhahu....L..hp................................p...hh..pl.......phhphp...hpthpt-...............................tpp....hslp..................................................................................ahp.h.sph.h......................................................cch+p.............................................hlps...hh.ctRhpKlpphs.hph.............................................ttstthhptLs..E.......................................................................	0	230	409	648
+5745	PF05917	DUF874		Helicobacter pylori protein of unknown function (DUF874)	Moxon SJ	anon	Pfam-B_8835 (release 8.0)	Family	This family consists of several hypothetical proteins specific to Helicobacter pylori. The function of this family is unknown.	21.90	21.90	22.10	22.10	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.50	0.70	-5.61	2	170	2009-01-15 18:05:59	2003-05-02 13:02:31	6	4	43	0	11	184	0	203.70	45	100.99	CHANGED	M.sl+sh........s.hAshhhph.pphKphpshpNlhhSlhGh..thhctl+s.lKKp.KKSs........hhCtpsKphDDhl......tp+.N..sWap.u.GlThhsuhLhssC.AsDpsKp.EltQtpKEAENARDRANKSGIELE.......QE+QKTpp.............KsEQE+QKTEQEKQK...........tspstIclEQppQKT.ppppch.ppQKDhlpcsEQNCQENHNQFFIKKLGIKuGIAIElEAECKTPKPsKTNQTPIQPKHLPNSKQPHSQRGSKAQEhIAYLQKELE.LPYSQKAIAKQVsFY+PSSIAYLELDPRDFpsTEEWQKENLKIRSKAQAKMLEMRsLKPDPQAHLsTSQSLLhVQKIFADVsKEIcsVANTEKKsEKAGYGYSKRM	...............................................................................................................................................................................Iclt.......QEpQKT.....................................................................................................................................pt.......p.....................................................................................................................................................................................................................	1	10	11	11
+5746	PF05918	API5		Apoptosis inhibitory protein 5 (API5)	Moxon SJ	anon	Pfam-B_8916 (release 8.0)	Family	This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterised by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors [1,2].	22.20	22.20	22.30	22.40	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	556	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.78	0.70	-6.01	3	205	2012-10-11 20:01:00	2003-05-02 13:15:00	6	6	113	2	125	191	0	385.30	36	88.30	CHANGED	pIEKLYEFsERLSESsDK.SQNV-DYEGIIKhSKTohKsKQLASQLIPRYFKFFPSLATEAFDAahDlhDDsDlGVRVQAIRGLPLFCKDTPDhlSKIlDVLVQLLNTEEPVERDAVHKALMSLlRQDTKASlTALFpHsusT.TTDEQIREKVL+FIRDKVlPLKGELLKPQcEMERHITDLIKKSLpDVTG-EF+MFMDFLsSLSIFGGKAP.ERMQELVEIIEGQADLNup...FphsDs-hl-RhIpChphAhPaFuRGAPSS+FLsYLNK+IlP..sFDpL.....PEERKLcLLKALAEMSPYTTAQ-.ARQlLPSIVpLLh.YMP........htcTs.phpFoasECLLYAhHpLu+KsPNATNSLCGYKIVTGQPSDRLGEDFSEhNKDFTERLThVEDLTKATMKKLTQGMoEHsKAMSsAKTDEEKuplKTK+.QsTTTGLRTCNNILAMTKsLatplPsFp+DhslsLSWhVssp....shlh++HtshoFh.............s.hspspohhGKRPA...NGuGNNV.uAKKuRsSN..QpQlVNKuuEGIS+sGu..SatGRGRsRGpGR+u..GGGRGRGp.sRGFW	......................................................................................t....lhp..thLsp.u.t..-....pp........p.tYp.IlpusK..u.s.sK.tKpLAuQhIs+FFppFPpLuppAlsA.hDLsE..D--...............h..t.lRhQAI+tLP.hsps......-.hs+luDlLsQ....LLt.......s.--ssEhphVppuLhslh+.DsKuoLsulFppl............p...s.-.....-.......hRE+....slpFlt..sKlhsh...phhp....pEhE..chlht..K.K.sL.p.D..VT..........u.pEF.hhM.phLtshp....ht.....shpuhpp.Llcll.p..QApLptt................hpss...Ds-...pl-Rhlp.Cht.A.hPhF..........sc.sspS...opFl.sahsc.p.llP...hstl...........................phpL..clLKhhAEhssa.......s.......s.s.-.....pp.l....lhphLhc.YMP.......................tt.p.p.t.....phpFoaVECLLashH.pLu++.hPs.ht.h....................u-phKDFp.R.....Lphhtc...hhp..shl+pL...p.uh...............pscstptl...K....scc..phphsuL+hssNI.slh+sLac.sP.ahss....ls.LSWh..tp..............................................................................................................................................................................pt........................................................................................................................................	0	46	63	92
+5747	PF05919	Mitovir_RNA_pol		Mitovirus RNA-dependent RNA polymerase	Moxon SJ	anon	Pfam-B_9906 (release 8.0)	Family	This family consists of several Mitovirus RNA-dependent RNA polymerase proteins. The family also contains fragment matches in the mitochondria of Arabidopsis thaliana.	25.00	25.00	27.70	27.30	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.78	0.70	-5.55	14	122	2012-10-02 12:54:00	2003-05-02 13:27:16	6	2	72	0	14	89	0	240.50	44	75.64	CHANGED	hphc.psphhsh.......+uGP.......suhShhoslhchhuhhtps..hphlphl...................h...h.hlsahpph..hhpsh...................hhsphtsh................lGKLulhc-stGKsRlhAhsDhhoQhlLpPLHshlFshL+plPp.DtTFsQp.shshhppchppt......aaShDLSAATDRhPlslQpclLshlhus.phupsWtsLLlsRsY..........tssss.lpYuVGQPMGAhSSWAhhsLoHHllVphuAh+s..ths.FscYlILGDDIVItscpVAppYhplMsc.LGVcIS.sKohlS..psoaEFAKRaht.stt-lSslslp..........uIlpslpp.hthhhs.lhchht+Ghp.......phls.h.ch.t..hlhh....tt.hhhsthhh....ht.......slphtpsllshpphhphltphh............t..hhs.thh................hshlhthlphshstphpslhhcphsphhhh.sphpsh.h.........hpp.pch.ph......L.tuh.hshh.plpchhsthhpptshsl.thhpshh...hshcsl	...................................................................................................................................................................................................................................llAMhDahoQhhL+PlHstLFphL+clPQ.DRTFsQssh.ch.ssccs........haShDLoAATDRFPIslQcclLhhl.............auc..phAsuW.tsllVpcta............hp.ths.lpYsVGQPMGAaSSWshFTLSHHllVphsAhhs...thspFp-YllLGDDIVIpNcpVAKpYlplMsp.LGVslScuKohVS....c..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	8	14
+5748	PF05920	Homeobox_KN	Coprinus_mating;	Homeobox KN domain	Moxon SJ	anon	Pfam-B_4610 (release 8.0)	Family	This is a homeobox transcription factor KN domain conserved from fungi to human and plants.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.08	0.72	-4.25	99	3978	2012-10-04 14:01:12	2003-05-09 13:11:53	6	46	463	5	1329	4786	10	40.00	54	12.00	CHANGED	WLhpphpp..PYPoc...p.....pK..........p..pL......uppT..ulohp..........Q.........lss.....WFINAR+R	........................................WhtpHh..ca...PY.....PoEs.........................-K..............................h...tL......App.T..GLs..p.................................Q......................................lsN......W......F.INtR+R.......................	0	325	626	968
+5750	PF05922	Inhibitor_I9	Subtilisin_N; 	Peptidase inhibitor I9	Yeats C	anon	Pfam-B_52 (release 8.0)	Domain	This family includes the proteinase B inhibitor from Saccharomyces cerevisiae and the activation peptides from peptidases of the subtilisin family.  The subtilisin propeptides are known to function as molecular chaperones, assisting in the folding of the mature peptidase [1], but have also been shown to act as 'temporary inhibitors' [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.73	0.72	-3.41	160	3390	2009-01-15 18:05:59	2003-05-19 17:25:16	11	124	1056	23	1630	3258	93	81.50	20	11.78	CHANGED	pYIVhhcpt.........................................hstsp......hssttphhp...............................................tsslhpsYct.......shsGauupLspppl.cplp.ppPsVthlp.Dphhplp	..........................................................................................................YIVh.hppt........................................................t.tp.................tthtphhp....................t...............................................tttsplhps...Ypp..............shsG......au.u.p.l......s.p....p.p.....l..cp.l........p......p..p..Ps....V.t.t....Vp.-phhph...........................	0	332	967	1374
+5751	PF05923	APC_crr		APC cysteine-rich region	Yeats C	anon	Yeats C	Motif	This short region is found repeated in the mid region of the adenomatous polyposis  proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin [1].	19.90	19.90	19.90	19.90	18.50	19.80	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.34	0.73	-6.92	0.73	-4.15	30	697	2009-09-11 05:34:41	2003-05-20 13:04:25	7	65	69	3	367	643	0	25.90	45	5.86	CHANGED	s-ssppas.sEcTPhs.FS+so..SlSSLo	..........-s.ppas.lEsTPhs.FS+so...SLSSLo..	1	42	74	178
+5752	PF05924	SAMP		SAMP Motif	Yeats C	anon	Yeats C	Motif	This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin [1].	19.60	19.60	19.70	20.20	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.28	0.73	-6.64	0.73	-4.65	11	249	2009-01-15 18:05:59	2003-05-20 13:43:35	6	48	46	2	126	209	0	20.40	55	2.10	CHANGED	---.ElLpECIsuAMP++pp+	...s-D.-lLpECIsSAMP++pp+..	0	7	18	54
+5753	PF05925	IpgD		Enterobacterial virulence protein IpgD	Moxon SJ	anon	Pfam-B_1987 (release 9.0)	Family	This family consists of several enterobacterial IpgD like virulence factor proteins. In the Gram-negative pathogen Shigella flexneri, the virulence factor IpgD is translocated directly into eukaryotic cells and acts as a potent inositol 4-phosphatase that specifically dephosphorylates phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] into phosphatidylinositol 5-monophosphate [PtdIns(5)P] that then accumulates. Transformation of PtdIns(4,5)P(2) into PtdIns(5)P by IpgD is responsible for dramatic morphological changes of the host cell, leading to a decrease in membrane tether force associated with membrane blebbing and actin filament remodelling [1].	20.70	20.70	21.10	20.80	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.80	0.70	-6.29	2	189	2009-01-15 18:05:59	2003-05-20 14:51:26	7	3	152	1	10	130	1	503.80	70	94.95	CHANGED	MpIpsh.hHpsShpot-uaKuhpcT...pGhpllShQthtsuc...........Rp.GsphhN..YLQpQ.TS.puht.LashcRshlhhtAhhL.GtpsshlpuMhpQh-hhKl.............ucs.K+Nl.EL...IutchptQ.Gl.sKct...htsth+ph.sp.LNNpsWpsIppslsaNG+pYs.p.hPAucMKIGsKsIFsptYpGKGlCshsT+p.+HhsNhWhSpV.Vc--GK-..lFsGIRHGVlSsYt.cKss..RtVuAcNKAcElhoAALaS+.ELLspALuGcsVsLKlVSsuLLTsoslhGtEtoMlcDQh+AhppL.op.Gc.h+LhIRNpDG.LQpVKlp.cVssFNhGVNELALKhGhGh+ssDphNuEulhpLLGsshh.puh.GGWsuEhltp.PsshpsV.hLApQIK-Ihppp.p+pDsGEPYKLuQRhAhLAapIsAVPsWNCKSGKDRTGM.DuEIKREIIphHpTt.hSt.sSh.sSttp+lFpplLhNSGN.t.pE.NTGssGNKVMKpLs.psLpLSYtcRlGD.pIWp.VKGhSShl	........................................................................................................MpIpsh.hHpsShpot-uaKuhpcT.hapGMQILSGQGKAPAKAPDsRPEIIVLREPGATWGN..YLQHQKTSNHSLHsLYNLQRDLL...TVAATVL...GKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIEL...IAART.QQQsGLP.AKEAHRFAAVAFRDAQVKQLN...N..QPWQTIKNTLTH..NG..H.....H...YT..NTQLPA.AEM.K....I..GAKD..IFPS.AYpG.KGVCSWDT+NIHHANNLWMS.........TVSV.H.E.DGKDKTLFCGIRHGVLSPYH.EKDPLLRpVGAENKAKEVLTAALFSKPEL..LN...+AL...p...GEA...VSLKLVSVGLLTA...SNI.....F......G...........K.EGTMVEDQM..RAWQSL.TQP.GKM.IHL.....KIRNKDGD....LQTVKIKPDVAAFNVGVNELAL.K.....L.G...F..GLKASD+YNAEALHQLLG..N.........DLRPEARPGGWVGEWLAQ.......Y.........P.D..N.....Y...E......V.....VNTL...ARQ...IKDIW.KNN.HHKDGGEPYKLAQR.LAML......AH......EI.......D....AVPAWNCKSGKDRTGMMDSEIK.REhISLHQ..THM..LSAPG.S.LPDSGG....QKIF.QK..V..L..LNS...GNLE.IQKQNT.GGA.GNKVMKNLS..PEVLNLSYQ.KRlGDENIWQSVKGISSLI..........................................	0	5	6	8
+5754	PF05926	Phage_GPL		Phage head completion protein (GPL)	Moxon SJ	anon	Pfam-B_1860 (release 9.0)	Family	This family consists of several phage head completion protein (GPL) as well as related bacterial sequences. Members of this family allow the completion of filled heads by rendering newly packaged DNA in the heads resistant to DNase. The protein is thought to bind to DNA filled capsids [1].	19.80	19.80	21.70	20.60	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.51	0.71	-4.35	33	714	2009-01-15 18:05:59	2003-05-20 15:03:08	6	3	529	0	73	507	5	136.30	41	87.08	CHANGED	sIsNs.GFWPDlsltchRcthRl-uolsspRLcpAllsAhupVNs-Ltsa+spppuuGassLusVPu.spls.GcuhhltpYcRAVashA+AsLhE+YpshDsTss.GpcpAcclspohs-LhRDucaAIpclhGpsR.ssVELI	..................................................IpNs.sFWPDlslp-hRpthRl.sus.Vo..s..sRLppshhuAlucVNsELhpa..+ppppst..GassLA-..V.......PA......s.........p.l.............s..G........cShplhaYppAVashA+A.LhER.YpshDsTsp..G...s++u....-plspsts-LWRDs+WAIucltstP.R.shV-LI..............................	1	8	29	51
+5755	PF05927	Penaeidin		Penaeidin	Moxon SJ	anon	Pfam-B_2675 (release 9.0)	Family	This family consists of several isoforms of the penaeidin protein which is specific to shrimps. Penaeidins, a unique family of antimicrobial peptides (AMPs) with both proline and cysteine-rich domains, were initially identified in the hemolymph of the Pacific white shrimp, Litopenaeus vannamei [1].  	25.00	25.00	25.50	26.30	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.98	0.72	-3.44	8	55	2009-01-15 18:05:59	2003-05-20 15:26:31	6	1	11	2	0	54	0	72.10	65	97.04	CHANGED	MRLVVCLVFLASFALVCQGQuYKuGYTRPlPRP.......Pa.....G.tshtsh.slC.suC+tLohSpARuCCsRLGRCC+htKG	................................MRLVVCLVFLASFALVCQGQsY+GGYTRPlPRP...........Pa.....G..t.....Phhsh.suC.suC+..sIohSpAR.uCCpRhGRCCHlhKG..	0	0	0	0
+5756	PF05928	Zea_mays_MuDR		Zea mays MURB-like protein (MuDR)	Moxon SJ	anon	Pfam-B_3145 (release 9.0)	Family	This family consists of several Zea mays specific MURB-like proteins. The transposition of Mu elements underlying Mutator activity in maize requires a transcriptionally active MuDR element. Despite variation in MuDR copy number and RNA levels in Mutator lines, transposition events are consistently late in plant development, and Mu excision frequencies are similar [1].	20.80	20.80	21.20	23.40	18.10	19.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.37	0.70	-4.90	4	19	2009-01-15 18:05:59	2003-05-20 15:35:39	6	1	2	0	1	21	0	203.00	85	94.63	CHANGED	MDhPPSKVVADAVEAARAAAVAASEARCAVFVAEKEAKAAVQFAAIAVDKVEAVKASSNVDLVDFKYHVNIKNSLRYAIQEMRRQoKLLHSVQKLCSTIPEVQGGKIGKVRGHLEHVCKELDKTSIVCEEDLETKNPTWDLYDNPSVDDEHPLDDDELGDGYSTEDPELWEMVF-DFKWEEIKANVSFEEHYRVINYRFEEINDRNM	.......MDhPPSKVVADAVEAARAAAVAASEARCAVFVAEKEAKAAVQFAAIAVDKVE....AVKA......SSNV...DLVDFKYHVNIKNSLRYAIQEMRRQoKLLHSVQKLCSTIPEVQGGKI.GKVRGHLEHVCKELDKTSIVCEEDLETKNPTWDLYDNPS.V.DDEHPLDDDELGDGYSTEDPELWEMsFEDFKWEEIKANVSFEEH.RVINYRFEEINDRNM..............	0	1	1	1
+5757	PF05929	Phage_GPO		Phage capsid scaffolding protein (GPO) serine peptidase	Moxon SJ	anon	Pfam-B_1730 (release 9.0)	Family	This family consists of several bacteriophage capsid scaffolding proteins (GPO) and some related bacterial sequences. GPO is thought to function in both the assembly of proheads and the cleavage of GPN [1]. The family is found to function as a serine peptidase, with a conserved Asp, His and Ser catalytic triad, as in subtilisin, and as represented in MEROPS:S73. The family includes SwissProt:P25478 from Enterobacteria phage P2 which cleaves itself and then becomes the scaffold protein upon which the bacteriophage prohead is built - a mechanism quite common amongst phages [2].	21.50	21.50	22.80	22.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.87	0.70	-5.15	5	734	2009-01-15 18:05:59	2003-05-20 16:35:53	6	3	536	0	77	566	6	255.80	42	93.46	CHANGED	SKaFRIAVEGATTDGRsIpR-WI--MAAoYDPcVYGARINLEHIRuhLPDGsF+AYGDVTALKAEEI-.sG..sGKLALFAQIEPT-DLlslNKu+QKlYTSMElsPKFADTGKAYLVGLAVTDsPASLGTEhLoFu.toAKsNPLAsRKQNP-NLFTsAEEssLEFEE.....lsE..oVssuLhs+VKsLFs+K-ASD...DARFuDVpEAVEsVAEHVQs..utTEppLuEtE+Ahot.cQplsspt-cpspsFscLKsoL-+T-uhuQptRPsATGGGu..slLTDC	....................KhFRluVEGsT.sDGRpIptpalppMAcoYsP.p.V.YsApINlEH........h+..u..hh...P...s...u....F.p.paG-VsuLp.uE..-..Is-..ss...LtGK..hALaAclpPT....-c.Llph.s.+.puQKlaTShE..lpP..p.FAsTG+AYLVGLAsTDsPASLGTEh.LpFs.....tps.p........p.ss.......l...s...sp........+.....t..s.s...t..s....L...h.os..A....-s.t..l..E..h....p-................tp...p.t.s.sh.hs...+V.p..ul......h...s...+...pptuD....................DApF..s...cl..pc....A......Vp.h..VApp.p...p...h.s...th...pttLs-.c..pp.........t......cptl............p.....t......p....pthstL...pppLp...p.p-u....p.......R...pATG.usu....s.hss...............................................................................................................................................................	0	10	33	56
+5758	PF05930	Phage_AlpA	AlpA; 	Prophage CP4-57 regulatory protein (AlpA)	Moxon SJ	anon	Pfam-B_2048 (release 9.0)	Family	This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light [1]. Several of the sequences in this family are thought to be DNA-binding proteins.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.25	0.72	-4.24	23	2885	2012-10-04 14:01:12	2003-05-20 16:46:44	7	8	1195	1	461	2198	442	49.80	31	65.72	CHANGED	pRhlRhtEVhphsGluRosIYchhc......cs.cFPppl+LGsRuVuWhpuEl-pWl	............................hlchtplh.phs.G...l..o.cs.tl.Yc.h.lp.........cG..pFP..p.s.l.+..l...G...............R...s.....s..s.......W.h..poElctWl....................	0	82	241	355
+5759	PF05931	AgrD		Staphylococcal AgrD protein	Moxon SJ	anon	Pfam-B_2868 (release 9.0)	Family	This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr [1].	20.50	20.50	20.70	20.80	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.30	0.72	-4.33	21	248	2009-01-15 18:05:59	2003-05-20 16:54:19	6	1	222	0	8	56	0	45.10	49	97.59	CHANGED	hplhshlhchhstlFphIGslAuhssCsuaFDEPEVPcELTcLac	.........ppLhNhFh-hlsslhcsIG.lAuhssCshlhDEsEVPcELTpLaE....	0	2	2	8
+5760	PF05932	CesT		Tir chaperone protein (CesT) family	Moxon SJ, Bateman A	anon	Pfam-B_2921 (release 9.0)	Domain	This family consists of a number of bacterial sequences which are highly similar to the Tir chaperone protein in E. Coli. In many Gram-negative bacteria, a key indicator of pathogenic potential is the possession of a specialised type III secretion system, which is utilised to deliver virulence effector proteins directly into the host cell cytosol. Many of the proteins secreted from such systems require small cytosolic chaperones to maintain the secreted substrates in a secretion-competent state. CesT serves a chaperone function for the enteropathogenic Escherichia coli (EPEC) translocated intimin receptor (Tir) protein, which confers upon EPEC the ability to alter host cell morphology following intimate bacterial attachment [1].\	    This family also contains several DspF and related sequences from several plant pathogenic bacteria. The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. DspF and AvrF are small (16 kDa and 14 kDa) and acidic with predicted amphipathic alpha helices in their C termini; they resemble chaperones for virulence factors secreted by type III secretion systems of animal pathogens [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.52	0.71	-4.26	52	1366	2012-10-01 22:01:34	2003-05-20 17:02:43	8	4	525	41	194	749	35	112.90	19	76.61	CHANGED	pLlpphuppluh...slshscsusssLth..spthhhlhhsppsspLllts.luphssstt......hhpplLphNh.h.tphtsshlulc.pssplhLptphshpt...lsts.phpshlpthlstscphp	......................................................hlpphupplsh...slt...h..s..p..s.shhtlhl....sp.hhhh.h..h.s.t..p...sp..h...l.hlhshlst.s.sss.s..........hhtplLph.N.h.h.tppssstlu.hs.pstpllLhhphshsp...hssp.pltshlpshlpphcth............................	1	71	103	148
+5761	PF05933	Fun_ATP-synt_8		Fungal ATP synthase protein 8 (A6L)	Moxon SJ	anon	Pfam-B_2993 (release 9.0)	Family	This family consists of fungus specific ATP synthase protein 8 (EC:3.6.3.14). The family may be related to the ATP synthase protein 8 found in other eukaryotes Pfam:PF00895.	24.20	24.20	24.30	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.34	0.72	-3.93	18	148	2012-10-02 21:03:42	2003-05-21 09:35:49	8	1	141	0	36	135	596	47.90	49	86.49	CHANGED	MPQLlPFYFlNplsauFlllolLlYlhSpYILPphlRLalSRhhIs+L	..MPQLlPFYFhNQlsauFlllslLlYlhSpYILPphlRLaloRhaIsKL.........	0	12	25	31
+5762	PF05934	MCLC		Mid-1-related chloride channel (MCLC)	Moxon SJ	anon	Pfam-B_2711 (release 9.0)	Family	This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer [1].	25.00	25.00	26.20	25.40	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.21	0.70	-12.78	0.70	-6.21	2	95	2009-01-15 18:05:59	2003-05-21 09:46:09	6	3	52	0	42	97	0	343.90	40	92.71	CHANGED	hpLhLh.sLhLsssYu.asD-WIDPoDMLNYDAASGpM+p.....................oQt.hthusEhc.sPDhoCusEhpEhhpKL-sLphpl-..EpK+hEc.cSpSpslF+RYLNKILIEAG+lGLPDEshschHYDAEllhphEhL.EIQpFLNstDWpsGALDDALSshLlpFKaHs.EpWKW+FEDSFGVDsYslhMllLClLClVhLlATElWTaltWaTQL+RlLIlShlhShGWNWMYLYKlAFAp+QAElAKhpshsp.CupKhsWotSla-Wh+uuhTapsDPCpcYachLlVsPhhhVPPTKALAlTFTsFlTEPLKHIGKGhGEFlpALhpEIPhhhplPVLIhhAlhlLuFhYGAGpuV....plhR+lsGPEpE.P.slcPpcppRpc.I-..........Dh+h.sthG...............pl.R-pDV..........spl.+t.slsDh-upppPsV.......shsscPp-TGtlhupsTsc..spEspp.tKsl..StpDppsNTEus.At.p..........................Rsp-PVspsht	..............................................................................................................................................hlh...h..hh...s..t...sD-.WlDPtDMLNYDusotpM+p..............................t.......p.....s....t.......s.p.tp...h..pl..h..pht..ppp.pht.p..ps............pst..lF+RaLp+hL.-ht+hGhspt............YDsplhhphp.h.El.thlttt.t.hp..uslspuls..ph..Lh...ph+.ps....ptWpWpFEs.Fsl.-..shhhlh...lslLhlVhll.s..TplaohltW....ahQ.lpRl.hhlsFlhShhWNWhaLYKhAaAp+...pspl...s..Kh.t..hsp.Cs..cc.hsW....tslh..-ahptth.Th..ps.DsCpcYaEhLlVsPhh.VsP.oKALulThTsFlsEPL.KalGpGhuEFlcuLh+-lPh.hhp.lP.VLl...h..hslsl.lshhahss.th.......................................................................................................................................................................................................................................................................................................................................................................................	0	10	12	25
+5763	PF05935	Arylsulfotrans		Arylsulfotransferase (ASST)	Moxon SJ	anon	Pfam-B_3266 (release 9.0)	Family	This family consists of several bacterial Arylsulfotransferase proteins. Arylsulfotransferase (ASST) transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate [1]. 	24.20	24.20	24.60	24.40	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.83	0.70	-5.99	33	999	2012-10-05 17:30:42	2003-05-21 09:52:45	6	8	517	6	144	1072	349	451.30	30	83.36	CHANGED	hlhlNPY...ssuPLoAllthsspphsslploVpsK.tpsuhsIsasss....ppthps+s..........lPVhGLYscatNpVplphsp..sGcs...hpcshplpssslssthsst..........pspshK.sssthtspLYhlss..................................s.pshsahlDspG-lRWahs.sthhstt............hcphpsGphhhsps...........pp.hhchDhhG+..hlpp.tcLsssa.............shpH-hhphsN.......GNhLltsup.p.h......s.......psscolcDhllElD.psGpllchWDlhclL..DPhRs..h...............................ptshsshsGss.su+sWhHlNultYDtpDDSlIlSuRHQsullKIs.....cspclpWIluspc..GWscp.......h.pphlLpPlct.G..h...............pusFcasasQHsshhlss....p.....lhlFDNGssRuhppsshs..............c..YSRuVcY+IDppshTVpQlWpYGKp+.G.chYSslsSss..-ahsc.sshhlhSusssh.............t.tt.........................lsEhchps...pcsth-hphpss.t.........sYR	.......................................................................................................................................................................................h.l.hsPY..s.sPLoAhl....ts...h.ts.lplplhsp...tps..ltaphs.......h..sa...........lPlhG..........Lh.ph.Nplplphtp....uph......p.th...h.sssh..........................phps.p.sssthpstL.Yhhsp..................................t.hsshshhhDppGp..h..R..aa.h.s..sth.h.s.........................hp.p...h....p.G.t..hh.h.sts..........................pc.h.h.c..aD.h.h..Gp.....hlhp......hcL..s..pta....................................................p.h..p.Hs.h...pt.s.N...............G.s..hllt.s...u..p....shhp.........s.............................hphpT.lc.....D.t.I.l.....E.V.......D..p....s....G.....p..lV.c.....W...c.hh.clL......DshRs.s.hh....................................................................pp.hu..s..h...sG...su...ss+sW..hHlNSl.......s.......Y..........D...s......p......D...............D............u..IIlSuRHQsullpIs..........csp.pl.+..WIL.u..ssp...uW..ptt........h....tth..lLpPVctpG..l........th............tps..sFcaoa.sQHsuahlspt...............h.lhsF.DNG.ssR..uh..-p.Ps..h.s........................................hp..YSR..hVp.....Y...p...I....D.p..p..p..h..TV......p...plW.....p........Y...G........K..-........c....G................c.......a..Y...S.s.hsSss...ch.ss...sshhhatushs.h...............tp...s....................hlpEhp.tp.ppshhEhph.us....................................................................................................................................................	0	48	86	119
+5764	PF05936	DUF876		Bacterial protein of unknown function (DUF876)	Moxon SJ	anon	Pfam-B_3279 (release 9.0)	Family	This family consists of a series of hypothetical bacterial sequences of unknown function.	19.60	19.60	20.00	20.10	19.20	19.50	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.11	0.70	-6.03	124	1520	2009-01-15 18:05:59	2003-05-21 09:55:25	7	6	940	0	277	1100	65	410.80	30	94.64	CHANGED	HFQQQ-Rah-thhctpspshssas..WGhppLp.lDpphLshG+lslppspGlhPDG.Thashstss.sh.PssLslss........................sstspl.VaLAL.Pltpssssp.ss.spt..............ssssRa..tspttcltDtpssssp.......................tplpluphslc...Lhhpp-..spssa...sslslARlhc..ps-GslhL.Dps.FlPPhLshtu.sshLtphlpclhshlptRucsLutRh.ssssp.s..usu-lscFhh...LpslNchtPhlpHl.hptsplHPEpLYppLhplsGcLsTFo........ps+psss.hPsYpHcshtssF.ssLhptLRphLssV..lpppshslsLp.pp...phuhhhuhlpDsplh.p..supFlLuV.+Ashssc.pLpppFs...ppsKlGus-clcpLVs.pLPGlsLpsLsssPp.plPh+sGhtYFpL.-.psushWpph.tpuuuhAlalsuph..s.sLcl-laAl+	....................................HFQQQpRah-ahhppphpshs.sa...WGhsplp.lsp-hLs.G+ltlppspGlhPDG.ThFsh...Psps..sL.Psslslps........................sptssh.laLAl.Plhpssttp.hs.spp..................pthuRa..p.ptt-l..pDhputtts........................tslpluphpl+...Lhhpp-.......sps..u.a...hslPls.Rlhch...pss...GsltL.Dcs.FIPPhlshpu..ush............L.....t.ph...lpclhshlptRupsLupRh..ss.ssp.t......usA-Vu-Fhl...LphLNRhpshlpHh.tp.hstlHPEpLYppLspLsG-LhTFo..........s+tsss.hssYpHcs.tssF.psLhstl+phLssV..L.spslslsLp...ph...p.uhhhAslp.-spLh..ppusalLAV.+AshPs-.pLpppFs...tpsKluus-clcpLVsspLPGlsLpsLsssPp.plPa+sGhpYFpL..D..pputhWpph.tpuuuhAh+luGsFs..sLphpLWAl+..............................................................................	0	46	113	193
+5765	PF05937	EB1_binding		EB-1 Binding Domain	Yeats C	anon	Yeats C	Family	This region at the C-terminus of the APC proteins binds the microtubule-associating protein EB-1 [1]. At the C-terminus of the alignment is also a Pfam:PF00595 binding domain. A short motif in the middle of the region appears to be found in the APC2  proteins (e.g Swiss:O95996).	25.00	25.00	53.00	53.00	19.50	21.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.20	0.71	-3.89	2	49	2009-01-15 18:05:59	2003-05-21 10:46:52	6	13	34	8	26	49	0	167.40	79	6.09	CHANGED	RSGRSPTGNoPPVIDsV.-pup.p.csuKDsps+pNsGNGsVPh....LENR.pSFIpVDu.DpKGT-.Ksh.NN....pETNEsolsERTsFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSsu-soouRPSQIPTPVsNsTKKRDSKT-oT-SSGoQSPKRHSGSYLVTSV	.........................RSGRSPTGNTPPVIDSVSEKGNsshKDS...KDNQuKQN.VGNGS..sPhRThGLENRLNSFIQVDuPDQKGTEsKPGQ.sNPVPsuETsESSlsERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDoTESSGTQSPKRHSGSYLVTSV.......	0	1	4	10
+5766	PF05938	Self-incomp_S1		Plant self-incompatibility protein S1	Moxon SJ	anon	Pfam-B_3292 (release 9.0)	Family	This family consists of a series of plant proteins which are related to the Papaver rhoeas S1 self-incompatibility protein. Self incompatibility (SI) is the single most important outbreeding device found in angiosperms and is a mechanism that regulates the acceptance or rejection of pollen. S1 is known to exhibit specific pollen-inhibitory properties [1].	21.10	21.10	21.20	21.10	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.90	0.72	-3.95	45	443	2009-01-15 18:05:59	2003-05-21 10:49:09	6	15	25	0	271	427	0	103.40	25	60.77	CHANGED	spVhIhNcL....s.....ssps.Lt..lHCpSp..-cDLGhchlps....sppasapF.....css..hh.tsThFhCphph....sstt.ptpFclYpsppc.t........tp.shWps+c...DGhahhppthsh................phphsWp	..........................h.tlhlhNph.....s.....ssps...lp..lHCpSp..-.c.D...LG.p...h...lt.......upph.p.a.pF.......c.s....hh..tsThF.h...Cshpa.......st...........hphpFcsapsp.c.-.ttt.............tp.ChWplpc....-G....lYhhppp.t.t..........................................................	0	78	141	181
+5767	PF05939	Phage_min_tail		Phage minor tail protein	Moxon SJ	anon	Pfam-B_3296 (release 9.0)	Family	This family consists of a series of phage minor tail proteins and related sequences from several bacterial species.	21.10	21.10	21.20	22.10	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.41	0.72	-4.10	33	1252	2009-01-15 18:05:59	2003-05-21 10:57:39	8	7	595	0	60	582	108	107.20	47	95.89	CHANGED	hETFsW..pspsss.ssssp.pV+pspFGDGYpQpsusGlNscppsasloasGscsphts.....lpsFLcRHuGs+uFhWTPPhsshslah..ssphpssshuushhsloATF-QsFp	...............hcTF+W..cl+ssM..pVsopPsVppV+FGDGYpQRtssGL..NspL..+TYs.V.T.hp....V.s+.p-.sps.......L-uFLscH.G.G.h+AFLWTP.P.a.s.h+p.l+V....sC..t..p..W..Ss....p......s.uh....hh.s..phoApFEQVV..............................	1	5	23	41
+5768	PF05940	NnrS		NnrS protein	Moxon SJ	anon	Pfam-B_3395 (release 9.0)	Family	This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family [1]. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase [2].	23.50	23.50	31.80	26.30	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.47	0.70	-5.56	122	829	2009-09-11 14:42:48	2003-05-21 11:06:32	7	3	628	0	253	740	124	369.60	30	94.48	CHANGED	t.s...lhp.hGFRPFFLhuulauslulsl..Wlhh...h.sGths.hs........hsslhWHsHEMLFGFusAllsGFLLTAlts.WTGp.slpGtsLh.......sLhsLWLsuRlsh.hhs..........hshhlshhlDhuFlshhuhhlu+.lhpu.+p.....hRNlhhlshLhlhshsNhhha.....hthh.tts.shtttshpsulhhlshllsl..lGGR............lIPhFTpshlt........sttst....shs.h.l-tsslhsshhshht.....hhhs...shl.suslhhsAuslphlRhh+.WpshtshppP.LLahLHluYhalslGhhlhu....huhh........shs.shusulHslslGulGshlLAMhoRsoLGHTGRs..L.tssts.hshuashlhhAAlhRlhsshhh...shhhhhltluushWshAFulashpYsPh..Lh....pPRh	..........................h..slhp.hGFRPFFLhuulaAslulhl..Wlhh.....h..sGth.s...h.........hsslhWHsHEMlFGFusAllsGFLLTAlts.WTGh.ss..spG.tsLs.......sLsslWLsuRlhh..hhs......................hs...hhl..ss...hl...-...shFhh..hhuhhh....up..ll.t.u.+s........hRNh..h...hlshlhhhsh.ss.hhha.....hthh....tts.h..h.....htshpsul..hh.h..s.lllsl..lGGRllPhFTpptls..........................................t..thh.................shhh...h-thsl.hshlhhhlh..................hhhh..........s.l...suslhhsA...us..h.p.hh.Rlhc.Wpsh.tshpcP..lLhhLHluYhalslGhlhhu..................huth.......s.h...s.ssulHhhslGulGshhLuhhsRsuLGH.TG.Rs...l...hss.s..hthAahhlhhAAllRshushh......shh....hhhltluuslWshAFslashpYsPhLhpsR............	0	68	149	209
+5769	PF05941	Chordopox_A20R		Chordopoxvirus A20R protein	Moxon SJ	anon	Pfam-B_3744 (release 9.0)	Family	This family consists of several Chordopoxvirus A20R proteins. The A20R protein is required for DNA replication, is associated with the processive form of the viral DNA polymerase, and directly interacts with the viral proteins encoded by the D4R, D5R, and H5R open reading frames. A20R may contribute to the assembly or stability of the multiprotein DNA replication complex [1].	25.00	25.00	68.10	67.80	17.90	16.50	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.98	0.70	-5.69	12	69	2009-01-15 18:05:59	2003-05-21 11:13:31	8	1	42	0	0	58	0	326.60	57	77.69	CHANGED	MoopsDLppLKELL+L+cslclu-ppsp-+YNuLV-WAopsYW+lulp+lssscsSIscYYpss+scs.FtLcsGcYhFLshpFGssalYh+G.shhELGSG.sthpIscch+shh-tllsc.sDlcFLRFVhF+ppWllEDshSchps.PhshLchAup.Glpsssalplc.lccsshFs--DYsslcphhtsh...csFhhsulChl+-Gs.cRpllDFhphsaspVcsI-LE.lssNhalPplITtsGpplLV+DlpHLlcS+s+hsoFVsV++h+shhlLs-psstss.E.o+uEsLpRIlcph.Gs-aFlN.GpYlSKl.sshslpplos+.LGl.hsCssl-	...MTS.SuDLoNLKELLsLYKSL+FSDuAAlEKYNSLVEWuTsTYWKIGV..pKVAslETSISDYY-ElKN...KP.FsI-PGhYIFLPlYFGoVFIYSKG.NMhELGSG.NohpIPD-hRSACsKVLcusssI-FLRFVLhN.NRWIhEDAlSKYpS.PVNIFKlASEYGLNlspYLcI-.IEEDTlFs-EhYulIE+uFc.....DpF.thSIsYIKhG-h+RpVVDFFKaSFMYIESIKl-+IG......DNlFIPolITKSGKKILVKDVDHLIRSKVREcoFVpVKKKNoFoILhDhsGsGo.E.TRuEVI+RII-.oI.GRDYYVN.GKYhSKV.GsAuLKQLoNK.LsI.s-CsTV-.....	0	0	0	0
+5770	PF05942	PaREP1		Archaeal PaREP1/PaREP8 family	Moxon SJ, Bateman A	anon	Pfam-B_2248 (release 9.0) & Pfam-B_9342 (release 9.0)	Family	This family consists of several archaeal PaREP1 and PaREP8 proteins the function of this family is unknown.	21.00	21.00	21.00	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.45	0.71	-4.22	116	500	2012-10-01 22:14:54	2003-05-21 11:19:01	6	1	40	3	319	475	0	112.80	25	72.44	CHANGED	s+LctAhh.hc.AtchLccG.htpAutKhapAhcthlpAlAtt.....h...hptcpphtttt.................hhptlsplhpphs.pplhhhhshAhs.LHtht..hh-sp..hshschpsppcshccll	.............................hl..Ahh.hp.A.chLc....cG........hhpAutKhapAhcthlpALuht...t.h....hppctch.tpp................................hhptlsplhpc.lG.ttlh.hh.sh...Ahp.LHtht..hh-sphthschppptpshccl...............................................................................	0	102	136	238
+5771	PF05943	DUF877		Protein of unknown function (DUF877)	Moxon SJ	anon	Pfam-B_2566 (release 9.0)	Family	This family consists of a number of uncharacterised bacterial proteins. The function of this family is unknown.	19.40	19.40	19.70	20.00	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.21	0.70	-5.99	95	1739	2009-01-15 18:05:59	2003-05-21 11:22:27	7	7	993	0	325	1173	101	394.70	43	83.71	CHANGED	l-phIup..IDptlSpQ...lstIlHpscFQpLEuuWRGLcaLVppo-...sspslKIclLsloKcELhcDhc..cus-hsQSsLa+plYpp.EaGphGGcPaGsllGDYpFspssp......DlplLppluplAAuAHAPFluuuuPphFGh-sap-L.ssh+DlsplF.-ss-..YspW+uhR-oEDuRYlGLshPRhLhRhPYus.cssPlc...sFsacEp........ss..scccYLWuNAAauhAsplscuFscaGWsspIRGspuG....GtVps..LPsH........hapss.GshphKsPTEltIoDRREtELuc.GFIPLshtKsoDhAsFauupSlp....KPpha.........psppAssNu+LuupLPYlhssoRhAHYLK.VlhR-pIG..Sapp.pp-lEp.LNpWlppYVsssss.ssp-h+A+pPL+pAcVp......VpElsGpPGaYpsshhl+PHaQh-shsssLpLVucLs	......................................pthIAc..lDpplScQlshIlHps-FQplESsWRGLchLVppT-.....hccslKlcl.L..sloKc-Lhc.Dhc..pus..-hsQ.SslaK+lYpp...EYG.p.hGGEPhusllusYtFspos.......DlpLLptlupVuAsAHuPFIuusuPphhth.cSapEL.ss.+DLsplF...-ssc.YspW+uhR-S-DoRYlGLThPRhLhRlPYu....s.cssPVc...sFsatEp.l....................ss.....sHpcYLWuNuAauhAsplscSFtcauWC.stIRGspuG......GsVc..sLPsH........hatot..GtlphKhPTElhIoDRREhELAc.GFIPLshpKsoDhAuFFu.ApSlQ.....KPt.a.............pst-AssNucLu.upLPYlFh..hsRhAHYlKsl.R-pIG..Sa+-.Rp-hEp.LNpWItpYVsspps.ssp-s+u++PLpsAc.V...Vp-.l.cG.p.PGaYpsthhlRPHFQh-GhshsLpLVucLs..............................................	0	64	150	236
+5772	PF05944	Phage_term_smal		Phage small terminase subunit	Moxon SJ	anon	Pfam-B_2645 (release 9.0)	Family	This family consists of several phage small terminase subunit proteins as well as some related bacterial sequences [1].	21.00	21.00	21.50	25.00	20.40	18.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.50	0.71	-4.49	36	711	2009-09-11 11:40:06	2003-05-21 11:27:24	7	4	530	0	70	559	9	130.40	42	55.90	CHANGED	hL.hpLspDpppLKslpShpcKsphKRc.lLPpYhsalpGsL....suGpGtQD-llspshlWtlDsGDhcsALclApYAlcas.LshP.-pFpR.ohsshlA-ElsshAt....pshpsupsh-sthhpp...........sh....clssst..DhPDpl	...............LhpLttDpccLKulpSpptKAthK+E.LL..P..catsWl-GsL............pu....Gt.u.t..Q.D..-.Vlh.plMlWtlDsGDhssAL-IucaAl+as.LsMP.tpapR.sssshlsEElus.sA.....ps.t.t.su...p...s.h...D....s....s....hLhp...................sh.....-lssst..DMPDp.............................	0	8	30	51
+5774	PF05946	TcpA		Toxin-coregulated pilus subunit TcpA	Moxon SJ	anon	Pfam-B_3639 (release 9.0)	Family	This family consists of toxin-coregulated pilus subunit (TcpA) proteins from Vibrio cholerae and related sequences. The major virulence factors of toxigenic Vibrio cholerae are cholera toxin (CT), which is encoded by a lysogenic bacteriophage (CTXPhi), and toxin-coregulated pilus (TCP), an essential colonisation factor which is also the receptor for CTXPhi. The genes for the biosynthesis of TCP are part of a larger genetic element known as the TCP pathogenicity island [1].	25.00	25.00	66.60	65.80	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.70	0.71	-4.26	14	136	2012-10-03 10:38:27	2003-05-21 12:21:49	7	3	59	7	5	90	0	125.20	64	58.82	CHANGED	uuLVsLGKlSsDEA+NPFoGsshsIhuh.cNuAu....NKuFAIpVsGLTQsQC+oLlTsVGDhFsYVsVpsuuusAhutLsDFtss.usAs.sGsGllKSlussupsLsLs-I.HlppLCp....ssusFuVshG	.sGLVSLGKlSADEAKNPFTGTsMsIFSFPRNuAA.....NKAFAIoVsGLTQAQCKTLVTSVGDMFPaIsVKpuAh.sAlADLuDFETosAsAA.....TGsGVIKSIAPuSsNLNLTsITHVEpLCs....GTusFoVAFG........	0	1	3	5
+5775	PF05947	DUF879		Bacterial protein of unknown function (DUF879)	Moxon SJ	anon	Pfam-B_3751 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	29.80	29.70	23.10	21.80	hmmbuild  -o /dev/null HMM SEED	602	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.70	0.70	-6.16	134	1615	2009-01-15 18:05:59	2003-05-21 12:25:26	7	4	942	0	303	1242	93	573.10	31	98.90	CHANGED	lLcYYpcELsaLRchutEFAppaPclAscLuhpt...spssDPaVERLlEGFAFLsARlppKLD--aPchTcuLLphLaPpYLpPlPShollphpPs.s...tlspuhplsRGotlpopssp.............tst....................CcFRTsp-lsLhPlplspuph....psssts...................puslclpL.....pssss..shupLs...........lcpLplaLsG.spthutpLachLhppshshhlp.sssp..............hsL.ssss...lp.sGFss--uLL..Phst.psFpGaRLLpEYFshP-+FhFhclsGL.......t..htts.........pphclhlhl.....tppsst.httplsspphpLaCoPllNLFp...ppu-PlplstppsE.Yhlhs.cpppstshElaSlcpVpuhpps..............tppp...............ah..Paauhpc...ttttst..pst.Yaph..RRcsphhsp..p.............salollcts........tpshp.......sh.ctLolclh.CTNRcLPpp.Lsh......sphshshtpu.ssstslpslpsPotPhts....hss.............phtWRLlSpLuLNaLSLh..........pusps.L+plLpLYshp.......ssstspcpl-ulhslpscssschls.....sshsRGlclpLslDpssF..sssshaLFusVLc+FauhasolNoFspLplhspppsc.hhpWssphGppsll	.............................cYYpcELsaLRch.ut-FAptaP+lAthLuht.....tps.sDP.VERLlEuFAFLouRlppKlD--aPEhTcuLlphLaPpYLpPhPSh...ullphpPchp.....phspshh.lsRsotltopsst.............tst........................CpFpospDlpLhPlp.lppsph....pssstt.....................puslplph................pstss...hshu.pLs.................LscLphaLsG..-phhsspLathLtpphhshhlp.sssp..................hsL...spth.......lp.hGFss..p-uLL....P.hst...s....s....apG....YpLLpE..YFsaP-+FhFhclsGl.............................sthhtth..tspthplhlhh.......p.p.sh.hthplstsphpLaCsPlINLF....+cu...-...slplstp.psE.Y.lhs.sp.p.p.s...t.caE.laSVspVhuhpps..............sspp....................a.PF.uhp+...psthst.....pst..Yaph...R..pcpphhspthp.......................phalullcts..........tssh.........stcslSlpl.h.CTNRcL.Ppp.lt.......sshshshpss..ssstshpslptPotPhhP....hcs.............phtW+LlSpLu...hNaLoLh........................tssps.L+phLt.lasht.............psphspp..pl-....ulhplcppsls+hhs.............s.....hhsRGlphpLsl-ppsF...stsshaLFGpVLp+FhuhYsulNoFsplslhstpptc.hhpWs.+hGpp..................................................	0	46	112	205
+5777	PF05949	DUF881		Bacterial protein of unknown function (DUF881)	Moxon SJ	anon	Pfam-B_4053 (release 9.0)	Family	This family consists of a series of hypothetical bacterial proteins. One of the family members Swiss:Q45543 from Bacillus subtilis is thought to be involved in cell division and sporulation [1].	25.00	25.00	25.50	25.40	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.64	0.71	-4.75	103	1279	2012-10-02 00:20:33	2003-05-21 12:37:39	7	1	506	2	348	917	13	150.00	28	57.10	CHANGED	ppclcphphhuGhssVpGPGlplTlsDsstt.............s.s.hhlpsp-.lhpllN-LhsuGAEAIuINs.........pRlsssotIcss..Gs..slhlss.phhss....P..asIpAIG-....sssL.psuls.sushhphhpth......ulplplpppc......plpl.suhsss....phpaAcss	................p..phpphthhuGhssVpGPGlplTlsDssts.................................t.s..hl.pspD..lhpllNpLhsuGAEAlsINs.....................pR.lsssotl+ss....Gs..slhlss.psh.u.s....P...YsIpAIG.c....spsL.psuls.....s..u..s...h.lpthcph......Gls.hp.lppp.c......plsl.suhsss..thpaAp..................	0	139	265	314
+5778	PF05950	Orthopox_A36R		Orthopoxvirus A36R protein	Moxon SJ	anon	Pfam-B_4070 (release 9.0)	Family	This family consists of several Orthopoxvirus A36R proteins. The A36R protein is predicted to be a type Ib membrane protein [1].	25.00	25.00	34.90	34.90	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.06	0.71	-4.30	3	57	2009-01-15 18:05:59	2003-05-21 12:45:40	6	1	22	0	0	43	0	129.00	92	68.68	CHANGED	MMLVPLITVTVVAGTILVCYILYICRKKIRTVYNDNKIIMTKLKKIKSSNSSKSSKSTDSESDWEDHCSAMEQNNDVDNISRNEILDDDSFAGSLIWDNESNVMAPSTEHIYDSVAGSTLLINNDRNEQTIYQNTTVVIN-TETVEVLNEDTKQNPNY	..MhLVPLITVTVVAGTILVCYILYICRKKIRTVYNDNKIIMTKLKKIKSS..NSSK.SSKSTDsESDWEDHCSAMEQNNDVDNISRNEILDDDSFAGSLIWDNESNVhAP..STEHIYDSVAGSTLLINNDRNEQTIYQNTTVVINE.TETlEVLNEDTKQNPSY.....	0	0	0	0
+5779	PF05951	Peptidase_M15_2	DUF882; 	Bacterial protein of unknown function (DUF882)	Moxon SJ	anon	Pfam-B_4115 (release 9.0)	Family	This family consists of a series of hypothetical bacterial proteins of unknown function.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-4.78	10	1137	2012-10-02 01:02:30	2003-05-21 12:54:22	8	4	1078	0	236	840	393	149.00	54	64.95	CHANGED	puuucsRsL+LaplHTGEKsEhsYhcsG+YspcuLp+ls+lLRDaRRNEss+MDPRLFDLlaplhppoGocsh.IpVVSGYRSPATNuhLRoRS+GVAKKS.HMlG+AMDFaIPGVsLK+LR-sulchQsGGVGYYPpSGSsFVHhDVGsVRpW	.....................................................hu.oscPRhLsLpNL.H.TGEsl.c.sc.Fa.c.G.c.s.Ylp-pLs+L..NHFhRDaR...s.N...cl.+sI.DPt.L...FDpLa..c....l...Q...s...hL...G..o..+...c...P.....lplI...SGYR..S.sTNsp.LR..u.+.....S...+..GVAK..+SYHh...+G..Q..AMDF..+I...............-..G......l..s........Lup....l.Rc..A......A..L......u...h....+..AG...G..V...G..Y......Y..PR..S....N...............FVHIDT.....G.PsRpW.....................................	0	56	120	171
+5780	PF05952	ComX		Bacillus competence pheromone ComX	Moxon SJ	anon	Pfam-B_4222 (release 9.0)	Family	Natural genetic competence in Bacillus subtilis is controlled by quorum-sensing (QS). The ComP- ComA two-component system detects the signalling molecule ComX, and this signal is transduced by a conserved phosphotransfer mechanism. ComX is synthesised as an inactive precursor and is then cleaved and modified by ComQ before export to the extracellular environment [1].	19.80	19.80	19.80	20.50	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.60	0.72	-4.46	11	61	2009-09-11 08:33:53	2003-05-21 13:51:57	7	1	39	0	11	48	0	54.90	33	97.18	CHANGED	M......Q-llsYLlcNPEVLcKltsG-AoLlGlsscpspsIlcuFpch.hhotts.h.W.s................t	......M...Q-llsYLlcNP-VlcclppGcASLlGlscc...phpuIlcuFpphphhp.hp...W...p.............	1	5	7	8
+5781	PF05953	Allatostatin		Allatostatin	Moxon SJ	anon	Pfam-B_4313 (release 9.0)	Repeat	This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata [1].	33.50	2.10	36.40	2.50	26.90	2.00	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.30	0.74	-5.77	0.74	-2.90	21	453	2012-10-01 21:03:17	2003-05-21 14:00:26	7	15	40	0	100	478	0	11.20	60	36.41	CHANGED	KRssp..YuFGLG	.........KRst.......YuFGLG.	0	52	66	88
+5782	PF05954	Phage_GPD		Phage late control gene D protein (GPD)	Moxon SJ	anon	Pfam-B_4333 (release 9.0) & Pfam-B_12199 (release 10.0)	Family	This family includes a number of phage late control gene D proteins and related bacterial sequences.  This family also includes Bacteriophage Mu P proteins and related sequences.	23.50	23.50	23.70	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.12	0.70	-5.22	283	5310	2012-10-01 22:58:23	2003-05-21 14:04:18	6	63	1555	10	1086	5029	137	285.80	18	48.10	CHANGED	pc.uls.p.hphplsh...h...................sssslthtt...hlGpslslpl..................................t.....hpGhl.................sph......t..............hus...cts.........Y...plslpshhthl........shp.p.cs+h.......a...ps.polscIlpplhs...............htLpt...t......hshhs.........assQap.EoDhsFlpRLhccpGlhah..hpp.tt...............p..pLllsDss.ss.....h............stsl.hhttsssss......tpslppap.htpphtsspspspsash...cpsptt.................h...t.............................................ss..hph..hpa.....................sst....................spup...phAch+h..-thpspspphpu..tussps.........l.tsGthhplsst............ts.hsp.......pallhplpaphp..ssh	.................................................................................................tthp.p.hphplph..h...........t..........pt.sh.htt.......hhsp.hplpl..................................................................p...hpGhl.....................sth......p..........hsp................stt.......hh........a......plpl....ps..h..h..hhh.............shp...p..sp+h...................................a........ps....p...o....l.....pIlpplhp.............................p....htlpt....p................h..t.hc...............a...ss.Q...at...Eo..DhsFlp.RLh.....tc......t.........Glhhh..hcp..t......................p.pLlhscss..ps....................................sttl.shh.s...sttps....................shp.php...ht..t..p.......h..t.s.s...p...lt..hps.ash.......cpspht...........................................................h...t.......t..p...................tts..hth......hpa.........................tsp.............................tpup..thu.p..h.ph......-thppts..........t..phpu...........tu.st.t..............l..hsGthhplps...................psthsp.....pahlspspaphp.p..t...................................................................................................................................................	0	223	517	791
+5783	PF05955	Herpes_gp2	Eq_herpes_Gp2; 	Equine herpesvirus glycoprotein gp2	Moxon SJ	anon	Pfam-B_4360 (release 9.0)	Family	This family consists of a number of glycoprotein gp2 sequences from equine herpesviruses.	25.00	25.00	318.80	318.00	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.61	0.70	-5.02	5	19	2009-01-15 18:05:59	2003-05-21 14:10:55	6	1	9	0	0	20	0	226.70	69	33.06	CHANGED	KNFMEASCTVET..NSGLAIFWKIGKASVDAFNRGTTHT....RLMRNGVPVYALVSTLRlPWlNVIPLTKITCAACPTNLluGDGsDLNSCToKSTTIPCPGQQRTHIFFSAKGDRAVCITSELVSsPTITWSVGSDRLRNDGFTQTWYGIQPG.VCGILRSEVRIsRssWRhGtso+DYLCElsASD..AKTSDYKVLPNAH...STSNFALVAATTLTVTILCLLCCLYCMLTRPRASV	KNFhcAoCTVET..N.GLuhFWKIGNASVDAFsRGTTHT....RlMRNGVPVYALVSTL+lPWlNVIPLTcITCAACsoNhltGstsDLsSCTsKSTTIPCPGQQRTHIFFStKGDRAVCITSELsS.PTITWSVGSsRL+NsGFoQTWYtIQPG.VCGILRSEV+IpRsoWRhGuso+DYLCElosSD..uKTSDYKVLPNAa...STSNFALVAATTLTVTILCLLCCLYCMLTRPRASV.......	0	0	0	0
+5784	PF05956	APC_basic		APC basic domain	Yeats C	anon	Yeats C	Motif	This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged  amino acids and interacts with microtubules [1].	25.00	25.00	71.10	38.20	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.47	0.70	-5.32	4	93	2009-01-15 18:05:59	2003-05-21 15:32:18	6	35	37	0	46	80	0	308.10	51	13.43	CHANGED	slhRGRTVIYsPustspsps.......soP.pKpuPPspspsusssKsPS.uQpRS+SLHRsuK.SphusLS.PsRSuTPPuRhuKoPSSSSSQTSssSpPh.p.pshsTpsuG...slPG.....PusuL..VP..pSPuRshhA.........pp+KTQ+SPVRIPFMQpss+..PsPLu.....pshsEPusRGhsthpussGA.uu+LtLlRMuSshSSGSE.SDRSG...FhRQhTFIKESPu.hLRR+RsEhSSh-StusospsASPpRupsthPAVFLCSSRCpEL+su..............PcQu.s.t...pQppPtuRss.u.h......ssRRToSESPSRLPl.Russu+.........sETsKRaASLP+ISlhRRssSusSlhouSu-	...............ul.RGRThIalPuspspopS.......ToP.pKpuPPh+s...s.u.....KsPS.uQptopS..RsuKsS.p.u-LS.ssRpso....ut.sKu.PSp..SuSpsSTPS+Ph.p.hspshQos...G.sph.PG.....Pssp.l.op...lP.ssS.PupAspp......ppsps+ho.pSPsR....Qs.sK...ssLu..so...shspsEsuS+G.hsthpsusGu.sp+lpLsRMoSs+SSGSE.SDRSt...hlRQ.TFIKEuPo.hLRR+hpE.uS..hE...S.husoops.sSPpRupsthPsl...Ssphs-hphu..............Pp.sss.....tptpPttRts.hu...........RopSESPSRLPl.Russh+..........EpsK+.uSLP+lSshRRssSuoSlhoAsu-...............................................................	0	2	7	18
+5785	PF05957	DUF883		Bacterial protein of unknown function (DUF883)	Moxon SJ	anon	Pfam-B_4421 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	40.00	40.00	40.00	40.00	39.80	39.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.97	0.72	-3.59	59	2283	2012-10-02 00:15:32	2003-05-21 16:01:49	8	2	1022	0	347	911	46	93.30	38	87.31	CHANGED	cplts-l.cpLhsshEcLLcpsustuspphppLRp+hpptLcps+splssstcs....stc+u+puscss-cY.......V+-pPWpulGluAu.lGhllGlLlu..RR	...........................t.clps-l.ppLs-oLE-VLcS.s....Gsp...ucpc....hpcl....Ru.+A....c....p.sL....ccs+tRls....psscs.......ltppu....+pAsspADcY...........V....+EcPWpu....lGlu.A.A.VGlllGlLLuRR......	0	46	135	243
+5786	PF05958	tRNA_U5-meth_tr		tRNA (Uracil-5-)-methyltransferase	Moxon SJ	anon	Pfam-B_4661 (release 9.0)	Family	This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalysed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.10	0.70	-5.76	9	7304	2012-10-10 17:06:42	2003-05-21 16:10:13	6	37	4224	7	1556	6444	1014	275.40	29	64.81	CHANGED	sYstQLp-Khs+LpshhAPFpuP-.EVFcSPspHYRMRAEFRlWHE..s--haYhMF-QtsK....p+lRl-pFPhASphINcLMstLlssh+ssssL++KLFQV-FLoTLSG-hlloLLYH+pLD-pWcpsApsLps.....thslslIGRu+tpKIslcpDYVsEpLsVsGRpahYRQlEsuFTQPNusVNpKMLEWAh-sspsppG.DLLELYCGNGNFoLALAppFc+VLATEIuKsSVsAAQaNIstNslDNlpIlRhSAEEFTpAhsthRpFpRL+..GIDLcSYphsTIFVDPPRAGlDs-ThcLVptY-RILYISCNPETLppNLppLpcTH+loRhALFDQFPYTHHMEsGVLLp++	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..............p.................s.............s.........p.........u.FhQ...s..N...s........t.........s....p.......p.....h....h....p....h....A....h....c......h.........h.............p.......h...........p...............t..........p.......c................l.....l......DhaCGh...Gs..h..u....L.....l.................A..................p.....p....s............p..................p........V..h...G..l.......El...s.p..u..ltsA..p..t..NA.......t.h.N...s...l...s....N...s....p.....a..h...t...h.t..u....p.p..h.h.......t.h.......t...............................................................t.....-.s..l...l..l.DPPR.sG..........h.s...p.......p.......h...h.....c.......h........l..........t..............p........h......p..........+......I...l.YlSCNP..s.T.L.A......R...D.................l..........p...............h.....L..............s..............p..........s..............Y............c............l........p........c...l......t.....................h........DhFPpTsHlE..s.lslLp+.h...........................................................................	0	504	946	1296
+5787	PF05959	DUF884		Nucleopolyhedrovirus protein of unknown function (DUF884)	Moxon SJ	anon	Pfam-B_4679 (release 9.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of unknown function.	25.00	25.00	134.90	134.60	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.19	0.71	-4.98	27	58	2009-09-11 07:37:26	2003-05-21 16:12:33	6	1	54	0	0	55	0	184.70	33	92.00	CHANGED	MslpLYpspsp...-s.loFphspshNSlhhahFphtss.ssssp............TRLVSGYEps+....sIshphsssss..............csuYllSChRsPplhhcLh..pp.astslshsVV+..spsp.............splWHVluV+KspEstph.p+lpulpVps...u.-ph..asKpLltlsGNlPusFlpuLsp.shsstp-lcslplhtPplpl	.MslpLYpspsp...-s.IoFphssshNSlslahFphtsssssssp..............TRLVSGYEsu+....sIshphsssss..............csuYllSClRhPhlhpcLh..pp.aopPluhllV+..spsp.............splWHVluVRKspEhtss.p+lpulhssp..sG.-ph..asK-LlhlsGNlPusFlsuLp+.shsshp-lcslplhhPplpl.......	0	0	0	0
+5788	PF05960	DUF885		Bacterial protein of unknown function (DUF885)	Moxon SJ	anon	Pfam-B_4405 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	22.10	22.10	22.10	22.30	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.00	0.70	-5.35	150	1292	2009-01-15 18:05:59	2003-05-21 16:37:19	6	10	669	6	493	1292	1570	510.40	24	89.45	CHANGED	sP.hs.ohhGht.tt...........tphs....D..h.Sspshppphpthpphltp..........................L.pslchs....sLsspsplshplhph..hppthtthpap...............t.hslspht..........uhhstl.shh.st.p.hp.........shp-..............................................hcsalsRLpshsphhsp.hhpphcts..htpGhh.P...chhhctslsph.........................................pshls................tshp.......ps.hhsshtph.t............thstpppsplttpsppslppplhPAhpph....hsahp..sphhsss...........pstGhhphP..........................sGcthYpht...lcthTT.o.chos--lHplGlpEVsRlpuEMctl.hpph.....Gh...p........s.....................sltchhphLps-....pah..p.........................s...t..ppllsphpthhpp............hp.stls.chF...t..plPc.sshtVchlss.......hhpsssss.uhYts.ss....Dss...pPGhaalNh.hs..........hpphspasht....sLshHEuhPGHHhQluhspEh.ts.lPthRph..s.....hh.o.AasEGWALYuEp.Lu.cEh.GhY.p.....cP......................................................hsc.................hGpLp.hchaRAsRLVVDTGlH..sc...............tWoR-p..............................................................................................................Alsahtcso.shsp..................................................................................................ssspsEl...-RYhs.h..PGQAhuYKlGtlcIhcL.RpcAc...ppL...Gcc...FD.......l+pFH-hlLppGulPLslL-ppl...ppal	.......................................................................................................................................................................G.tt.ts...........phs-..h.Sstshptphthhpphltp..........................L..pths.s........tL.s.s..p.pp..lshp.lhp....t..ph..p...thp.ttpht..............................hslstht.............uhhtt..l....th..h..s.....hshp..............s.pc.........................................................................................................................hp.shhtRLps.lsthhsp..hhtp..hcts....httGhh.s......phhhpth.ltph...........................................................................................pshhs..............t..............tshhh.sshtph.s.............hststp..splptph.tpslttthhsAapph................hsalpsphhsts...........pp.uh..ph.s..........................sGcphYphh...l+thss.s.sh.ss.........c-la.p.hGhpEltRlps-hppl.tcpl........sh......t...........s...................................shtphhphLcs...-....th........................................................tt......ptlhp.hp..t.hhcc................hp.stls..phF......plPc..t.h.lc.l.s..........hh.t..sstss..uh...Yhs...ss.....Dts.....cPG...hhahss...s..............hpphs.pa..p....h...........shshHEuhPGHHhQhuhstph..ts.lstaR+h..s............hh.o.uasEGWALYu.....Et.Lh.p-h..Ghh.p......DP.............................................................................hpp........................hGhLs.hphhR..AsRlVlDhGlHhp.......................................tWoppp..............................................................................................................Ahsahtpps.shsc.....ss....spsEl.....cRYhs...h....PGQAhuYplGphplhcL...RcpAc...pph...Gsp....FD...............l+tFHstlLp.GulPlslLcptlt.....................................................................................	0	191	354	434
+5789	PF05961	Chordopox_A13L		Chordopoxvirus A13L protein	Moxon SJ	anon	Pfam-B_5061 (release 9.0)	Family	This family consists of A13L proteins from the Chordopoxviruses. A13L or p8 is one of the three most abundant membrane proteins of the intracellular mature Vaccinia virus [1].	24.10	24.10	29.60	35.80	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.37	0.72	-4.04	8	55	2009-01-15 18:05:59	2003-05-22 10:44:54	6	1	35	0	0	40	0	68.40	66	99.31	CHANGED	MIuDllLlIICVsIIGLIVYGIYNKKoosppspPus...EcY.KhEslKTuYVD+LKsuHLsSFYKLF.Sup	MIGILLLIGICVAVTVAILYuhYNKIKNsQNPsPus...lNsPPPEs+N.TKFVNNLEKDHISSLYNLV.SS.u	0	0	0	0
+5790	PF05962	HutD	DUF886;	HutD	Moxon SJ, Rainey P	anon	Pfam-B_5160 (release 9.0)	Family	HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterised repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription [1]. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.	25.00	25.00	30.70	30.60	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.27	0.71	-4.56	106	985	2012-10-10 13:59:34	2003-05-22 10:47:25	6	6	936	6	178	684	43	176.70	33	90.44	CHANGED	lchsch.ssPWKNGGGtTcEIsh.aP.........sGu......shcsFs...WRlSlAslupsGs..FShFsGl-RhlslLpGsGhpLphs...........ut.p....pth..........htPhp.shuFuG-sslsupLhsGs.spDFNlMsRcsthpuplphh....ss..............shph........susssl......lashsG.s....hp.......ls.s...........sphtLpst-sl................hhcs......................ptsl...lpsp....ut.lhhlpl	..............................chpchsss.W+NuuGpT+EIss..a..P..............................sut......c-Ft.....WRhSlAolussGs..FShFPGh-RhlolL-G.sthhL.pss.............................sp...s....cs................LpPhp.PauFuuDtslpucLhsGt.shDFNlMoRhsh.tpuplc..hh......pt.............................................shph...........supssl..........laslsG..s.......hp..lss............................phhh.sspssh....hhcs............pppl......hpst....uthhh...............................................................................	0	33	72	125
+5791	PF05963	Cytomega_US3	Cytomegalo_US3; 	Cytomegalovirus US3 protein	Moxon SJ	anon	Pfam-B_7187 (release 9.0)	Family	US3 of human cytomegalovirus is an endoplasmic reticulum resident transmembrane glycoprotein that binds to major histocompatibility complex class I molecules and prevents their departure. The endoplasmic reticulum retention signal of the US3 protein is contained in the luminal domain of the protein [1].	25.80	25.80	26.10	39.90	20.10	25.70	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.37	0.71	-4.95	3	63	2009-01-15 18:05:59	2003-05-22 10:51:40	6	1	10	4	0	61	0	179.40	54	97.57	CHANGED	MKLVhlLAuLAsLl.LshuDusPRPlssIsS....clTuh.sHFpVEENcC+lHMGplYFRG+lSGNFTc+HF...VsaGIVSpSYhDNLpVouEQaca.cAGsYFEWNVpGtsVsasVDpVDVpLSosWGDPKKWAoCVPQVRsDYoS.shhWYhQhuMhccoWuhhhhsVhhYsLShhhLshhhVhholp.......MRFF	............................MKPVLlLAILAVLh.LRLADSVPRPL-VVVS....EI+S..AHFRVEENQCWFHMGMLaaKGRMSGNFTc+HF...VsVGIVSQSYMDRLQVSGEQYHHDERGAYFEWNIGGaPVsHTVDMVDITLSTRWGDPKKYAACVPQVRhDYoSpoI.WYLQRuMRccsWsLlh..RTllsYhhulslLVLlsVtVSs+.......hRF...............	0	0	0	0
+5792	PF05964	FYRN		F/Y-rich N-terminus	Yeats C	anon	Pfam-B_1170 (release 8.0)	Family	This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.	21.00	21.00	21.00	21.50	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.57	0.72	-4.51	45	555	2009-01-15 18:05:59	2003-05-22 10:52:30	9	76	143	1	361	515	8	52.30	35	2.49	CHANGED	huoLtlhsLGpllssp..sFHspphIaPlGYpusRlYhS....hpcspc+shYpCcIh-	...................GulhlpslGpllspp......t..acspptlaPlGYp..soRlYaS....hpcsp.++ChYpCpIh.t................	0	123	177	264
+5793	PF05965	FYRC		F/Y rich C-terminus	Yeats C	anon	Pfam-B_1170 (release 8.0)	Family	This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.72	0.72	-4.17	48	561	2009-01-15 18:05:59	2003-05-22 10:57:39	9	65	144	1	363	525	9	85.00	28	4.25	CHANGED	sspPhFcls.s--......s...hshpusSssssWppllcplpp..h+pppt...........tslsG.-hFGLspsslhpllEsLPsscpCppY...phchtc	.................................................t..tPhFcIp..s--.........s....hshpusSspssWp.pllctlpp.....hRppsp......................hth...tt...lsGtchFGlspsuVhpllEpLPGscpCppY.....pFch.........................	0	122	175	266
+5794	PF05966	Chordopox_A33R		Chordopoxvirus A33R protein	Moxon SJ	anon	Pfam-B_4799 (release 9.0)	Family	This family consists of several Chordopoxvirus A33R proteins. A33R plays a role in promoting Ab-resistant cell-to-cell spread of virus [1] and interacts with A36R to incorporate the protein into the outer membrane of intracellular enveloped virions (IEV) [2].	22.50	22.50	22.50	22.80	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.34	0.71	-5.52	6	66	2012-10-02 16:37:33	2003-05-22 11:01:42	7	1	42	2	1	66	0	170.40	47	96.24	CHANGED	hsspps.Dh.c.s-ptsuFhGSTIYGsKL+.KKphtKKs+sluIsLRIullsSllSLhsIsshLAlQhspCcssp-t.psspulsshs.hosptphstSth.....cpCpGIha-GtCYphssEspo.Fs-AspsCtscuusLPu.ssLhpc.........WlhDYL-GTWG--Gtsl........sKpps.-lpssDlSsEhRsYFCV+Shs	................................................................hhss..........-sc-ppTuhhuuTlYGcKlp.u.Kp...K++RsIulCIRI...ShVISLLSh.ITh.oA.hL.hl.c.L...NpChSss.Eushoctulsssu...u..o.spc.csuuSsop.......................cSC...s.G...LaY.pG.u.CYIhHS-hph.FsDApAsCsscuSoL..Ps..oDllsT.........WLhDYlE-TWGsDGNsI........sKoos...-h...p-uDlSpEsRKYFCVKoh......................	0	1	1	1
+5796	PF05968	Bacillus_PapR		Bacillus PapR protein	Moxon SJ	anon	Pfam-B_4892 (release 9.0)	Family	This family consists of the Bacillus species specific PapR protein. The papR gene belongs to the PlcR regulon and is located 70 bp downstream from plcR. It encodes a 48-amino-acid peptide. Disruption of the papR gene abolishes expression of the PlcR regulon, resulting in a large decrease in haemolysis and virulence in insect larvae. A processed form of PapR activates the PlcR regulon by allowing PlcR to bind to its DNA target. This activating mechanism is strain specific [1].	21.10	21.10	21.20	22.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.20	0.72	-3.90	3	118	2009-09-10 20:50:31	2003-05-22 11:30:16	6	2	101	0	3	32	1	47.80	83	93.33	CHANGED	MKKLLIGSLLTLAMsWGISLGDTALEKsQlISHssQEVQLASDlPFEF	....MKKLLIGSLLTLAMAWGISLGDTALEKSQlISHNDQEVQLAuDlPFEY.	0	0	1	1
+5797	PF05969	PSII_Ycf12	DUF888;	Photosystem II complex subunit Ycf12	Moxon SJ	anon	Pfam-B_4945 (release 9.0)	Family	Ycf12 has been identified as a core subunit in the photosystem II (PSII) complex [1-2].  PsbZ has been shown to be required for the association of PsbK and Ycf12 with PSII [2].	19.60	19.60	19.70	19.70	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.97	0.72	-7.29	0.72	-4.32	40	232	2009-01-15 18:05:59	2003-05-22 11:34:02	6	2	219	13	31	179	2	32.40	54	71.40	CHANGED	M..NhElIsQLssLsLIllAGPlVIsLLuhRpGN.L	......M..NlElluQLssLuLIlluGPlVIsLLAhR+GNL......	1	11	26	31
+5798	PF05970	PIF1	DUF889;	PIF1-like helicase	Moxon SJ	anon	Pfam-B_4988 (release 9.0)	Family	This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated [1][2]. This family includes a large number of largely uncharacterised plant proteins.  This family includes a P-loop motif that is involved in nucleotide binding.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.09	0.70	-5.51	13	2557	2012-10-05 12:31:09	2003-05-22 11:41:20	9	118	754	0	1533	3113	626	193.20	19	32.75	CHANGED	pLssEQ+pla-pIlpulhs.spGthFFVsGaGGTGKTaLWpslhstlRS..cscIVLsVASSGlAuLLL.GGRTAHSRFtIPlshsEtSpC..sI+puoclA-LlpcsuLIlWDEAPMssRpCFEALDRoLRDIlppps....sKPFGGKsVVlGGDFRQILPVlp+GuRspIlsAslssShLWpc.s+.lLpLT+NMRLtssthstpctcclpcFupWlLslGsGclssssstt.......shIplPpDLLlppss.cslcsllsclYsc..llpshss.sahppRAILsPsN-sVsclNsallspLsG-E+pYLSsDols.ssps..c.-hlYPsEFLNSlsssulPsHhL+LKlGsPVMLLRNLs.ohGLCNGTRLhlTpL	..........................................................................................................................................................................................h..h..h........G......uGsGKo....hhhp..............h...............t...........h..........................................h..h.hh....us.o....u.....h.u..u...........h..............t..........G.........................T.h..H....p..h......h.....t......h.................s...........................t......................................................................................................................................................................t.............h............t.....h.p.....hllhDE.....hsMh.....t.....t................h..t....h......l.......p.............h...p.h..................................t...F..G..G..h.......ll..h..GDhhQl........P.............l..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	583	1068	1392
+5799	PF05971	Methyltransf_10	DUF890; 	Protein of unknown function (DUF890)	Moxon SJ	anon	Pfam-B_5064 (release 9.0)	Family	This family consists of several conserved hypothetical proteins from both eukaryotes and prokaryotes. The function of this family is unknown.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.91	0.70	-5.27	4	1276	2012-10-10 17:06:42	2003-05-22 12:58:10	7	11	1113	3	405	2121	363	263.00	45	81.71	CHANGED	tA.psuLHPRNRH+u+Y.DFstLhpssPELcpaVhlNPtGc.SlsFADPhAVKALN+ALLtpaYuVs.WDIP-GaLCPPlPGRADYIHalADLLucusss.hss..thRuLDIGsGANCIYPLlGspEYGWpFlGo-lDs.ulspAptIlpuNspLsstIclR+Q.ppptIFsGlIttsE.pYDhThCNPPFHAShs-AptGopRKhpNLtp.s..........s.s.s.LNFGGQtsELaCEGGEssFlt+MhcESptFApQVhWFooLlSKusNLssLpcpLcplGAsclphhEMAQGQK.SRFlAWoFhs	.............................................................................p...+ssLHPRN+H.ps.cY..Dh.stLsps.P-.L.ppalh.......h....s......s....t..G.........c.S.l........DFusP..AVKtLN+AL.LtcaYuls................WD..IP...t...saLCP.PlP...G..........RADY..IHa.l.....A.....D......L.....L.........u........p.......s.........s......s.......s...lst......................psp.hLDI..G..sGA.NC..I....YP.L.l..........G.s..p.....c..Y........G........W..p..F.s...G.o...................-lsst........ulssAp....tI.l..p..sN...ss......L..sp.t......I..c..l..R....p........Q........p.....p....s...t.........t.................I...F..........s....G.l....l...p...p.....s.....E.......pa...........D...hThC.NPPFH..sS...t...t...t...A.....p...t......G...o...p...R......Khp..s..Lth................................................t......LNF....G.Gpp...p...E.L.W....C-..GGElsFlp+......M.I..pES..t..t........a..t...c..........p...........V..hWFToLlS..+..tp..NL...sslhctL...pc..........h......G......s..s....p.....l....hhhE..M..uQ...G.......Q.K.t.S.RhlAWoFh............................................................................................	0	123	207	320
+5800	PF05972	APC_15aa		APC 15 residue motif	Yeats C	anon	Yeats C	Motif	This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin [1] along with the Pfam:PF05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.	19.40	19.40	20.10	19.50	18.90	19.00	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.92	0.73	-6.36	0.73	-3.62	9	272	2009-01-15 18:05:59	2003-05-22 13:01:02	6	30	58	2	142	273	0	16.00	53	1.96	CHANGED	c.-QPhDYShKYuEcp	.-.DpPhsYSlKYu--p......	0	13	22	62
+5801	PF05973	Gp49	DUF891; 	Phage derived protein Gp49-like (DUF891)	Moxon SJ, Bateman A	anon	Pfam-B_5075 (release 9.0) & Pfam-B_6067 (release 14.0)	Family	This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	23.90	23.90	23.90	24.00	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.05	0.72	-3.97	226	2071	2012-10-03 00:18:00	2003-05-22 13:01:19	9	4	1184	0	551	1798	191	86.10	24	77.55	CHANGED	calpsL....cp.........ht...sclhtplppl.ptG........hhsshp.....pGlhElRl..chss..saRlhashctsp....hl.llLpuhsKpo...........pp-IchAcphhc	......................................hpth...spp.........ht...tplhhtlphltptG.........shspphp........pslhElRh....phss...hhR.lh.as.hchsp..........hl..llLpuh.pKpo.......p....p.h.pp-IchAcphh......................	0	143	347	476
+5802	PF05974	DUF892		Domain of unknown function (DUF892)	Moxon SJ	anon	Pfam-B_5115 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function.	23.70	23.70	23.70	23.80	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.80	0.71	-4.42	111	1538	2012-10-01 21:25:29	2003-05-22 13:04:39	7	2	728	12	337	830	49	154.30	41	91.00	CHANGED	slc-lalctL+DlYsAEcQhhcsLschuctAps.scL+suhcpHlpETcsQlcRL-plhcth.GtpspuhpCcuhpGlltEupp.lhcp.hpcps.lpDAsllsuuQthEHYEIAuYGoLhshAcpLGh........s.-ssplLppsLpEEpssDctLsplA.p.....shssttus	...................................p-hahchLpDsauhEKQhpphLtphA...........pths.....N....sc....L.p....tt....hcpHLpET+sQIppl-pll-pp.s.lphp......shK..suMpulhtpupp...lh.t...s..pcp..V+suh...uu.thE+aEIA.s......YsoLhshAcplG.........s.cuhtlLcphLpEEKthsphLpphh.......psspphh.......................................................	0	95	191	252
+5803	PF05975	EcsB		Bacterial ABC transporter protein EcsB	Moxon SJ	anon	Pfam-B_4764 (release 9.0)	Family	This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters [1].	25.90	25.90	26.10	30.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.26	0.70	-6.00	52	1578	2009-01-15 18:05:59	2003-05-22 13:16:12	7	2	1026	0	136	965	1	282.60	25	96.02	CHANGED	hppLapcRhpphhpcph+Yl+alhNsHhllhLlh.llGhhuhhYsphLpph..sssh..hh...hllsllhhhllh.hGpltThlccADplFLLshEpc.hpsYlppuhhaShlh.hhh.sllhllhhPlhh..thshshhthlhhhlhhlhhKhh.hhhphphhhhp.............phh.hhhhhhlshhhhhhhh..........hhhhhhhhhlhhhhhhhh.th.ptphhsWcthIphEpc+ttphh+hhshFT-V.plppps+..RRpaL.Dhll...+hlttpp.ppsahaLahRuFlRus-ahulhlRLshluhlhlhh........lsp...alshllshlhlYllshQLhslappactphhhpLYPlsppp+hpuhppllphllhl.sllhslhhhl.thphhhsllhlhssllh	..........ttla.pRhtthhpp..hY.phhhNshhhhhhlh.hhuhhhh.Ysphlpph......s.ph....hh.....h.h.hs.lh.hhhh...ht.ltohhctsDhlFLLshEpp.hp.ahptthhhohhh.hhh.hlh.hhlhhPlhh.....ths.h..hhhhhl.....h.hhhhhhh..hhhph..hh....................................................................................................th...hs.Wphhlt.Epp+h..hhphhshF...T...s...V.t.lp.p.p.st....+RtaL..chll...phhth.....ttha..LahRsalRss-hhslhhRLhhluhlhhhh..........l........hlshhlshlh.YllhhQhhshapt..ht.ht..hh.plaPlstt.t.p.tsh.p.hl.hhh.h.hhl.h...lhhh.hhh..t.hhhhhhhhhh.hh...........................................................	0	25	62	96
+5805	PF05977	MFS_3	DUF894;	Transmembrane secretion effector	Moxon SJ, Eberhardt R	anon	Pfam-B_4880 (release 9.0)	Family	This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin [1], and a protein involved in antibiotic resistance [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	524	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.56	0.70	-6.39	10	4536	2012-10-03 03:33:39	2003-05-22 13:26:29	8	16	2237	0	1344	14705	3116	396.30	20	94.58	CHANGED	sSuaAPLRpssFRslWlAolluNlGshhQsVAuuWLMTolSsSPlMVALVQAAuTLPlFLLulsAGAlADsaDRR+lMlsuQslhAsuSshLslLutlGhloPWhLLuhTFLhGsGuALssPAWQAoVs-lVsRcDVPAAVuLNSlGaNlsRSlGPAlGGlllAuaGsAssFAlsslSYhslIsslhpWKhcsssssLPpEsltsAl+AGLRaothSssl+sVLsRuslFGLuASAlhALLPLVARDpLuGsAhsYGlLLGuhGsGAlsGAlhss+LRcRlsu-pLlthAsluhAhssLsLALosshWlsslsLhluGAuWlsALoslssuVQhusPcWVhGRsLSlYhslhhGGhAAGSalWGsVAEshulssALlsuAsuLLluuhluhhhtLPptcs.DhsPtsc..aspPhVAhsLcPRsGPlllpIEYpIsc-ctssFLcsMtEhR+lRpRsGAcsWsLtRDLpsPppWlEpFhssoWh-aLRppcRlTpADttVpp+lpAhHsGspPPplp+hl...cRPs	...........................................................................................................h.................s....a.t.h....h...h...h...u..p...h...l.o......h....u..........h........h.......h.......t...l........A....h.....s....h........h.......l........h........p.......h.......o........t.......o.......s.......h..h.....l................u....l.....l..s...h.....h...p....h....l.........P...h.....h.....l....h.......u.....h.......h.....u.......G.s.....l.......A.....D............R....a.s.....+..+....+....l........h.....l.....h...s.....p.......h....h....t..s.....l.......s....s....h....h......L.......s........l.......h........s.................h.......h.......s.....h.......h....s.......l..........h.......h.......l....h....h....h....s....h....l....h....G....h....h...s....u....h....t......s....P...u....h...p....u...h....l...P...p..l...V..s....c......c......p..............L...s......p....A....s....u...l......s...............s...h......s...........h...............p.............h....u.........p...l.....l...G..........P....s.......l..u.........G.......l..........l...........l..............u.............h.................h..............G............s.........s.............h..................s..........a...............h..........l.......s.........u........h............s........a......h....h.......s......h.....h......s.........l..........h.....................t...........l...........t............h...............t..............h.............................................t........s..............h..............s..............p..........p................p................h.......h............t........s..................l...........h.............t.......G.............h......c.............a.....l.....h......p.....p..............h.....l........h........h......h..........h........l.....h.......s.....h....l....h.....s........h.........h..........s.......s.....s......h.....h......s........l.......h............P....h...........h...u......p.........p......h.......h........t..............h.........u........s....t..........t..............h..........G.......h........l........h...u....s....h.....u....l.....G..u..l..l..G...u...l.....h...h....s......t......h........t........p.....p.......h...t...........t.......t......h.......h........h.......h.........u.........s........h.........s.......h.......u.........l........s.....h.......h....h.........h..............u.....................l............s.................s..........s.............h..............h.........l...........s.........h...........h.......s.......l........h.....l....h..........G.......h.......s...h......h.......h......s....h......s....s.........h........p.............s.......h.....l.............Q....t.....t.....s...P..s....p......h......h....G....R......l.......u......l....h...t....h....h....h..h.....u.......u.......s........l....G...s....h...h...h....G...h....l....u....p....h....h.......u.....h...h........h....s.....h.....h.....h.....u.....u....h...s...h..l..h...s..s....h..h..h..h...................................................................................................................................................................................................hhthh.....................................................................................................................................................................................................	0	468	932	1185
+5806	PF05978	UNC-93	DUF895; UNC-93_Ce; 	Ion channel regulatory protein UNC-93	Moxon SJ, Pollington J	anon	Pfam-B_4965 (release 9.0)	Family	This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.74	0.71	-4.73	11	630	2012-10-03 03:33:39	2003-05-22 13:29:58	11	10	174	0	479	1149	24	133.40	22	29.75	CHANGED	LGhuahhlFoAasopuFItEuVIcSlp-ps.ss.IssaAGYYuhAllYhsFohusLhsPslVshlosKWuhlluuhsashF.hGFLahNpaahYhoSAllGhGuuhlWsGpGsYLoppso+cThE+Noul.WAlhpsSLlhGGlhlhhh.aphpsstuh	.........................................................................................................t.t...G..hhu..hullY..ss.h....s.lus.h.h....s.P....s.l.l....ph.l..G....s.K...h....ol..hl....u....s.h.s....Y..s..h.....a............h.s.....u........h.....a.....s......p.......h............a..............h....h....h....s.u.u.sl.l..G.h...uuu...............h.lW.su....p.u....s...a..........l.......o......p...........h.....s......p..........t...........t.....p..........h........t........p..........................sh.......h.h..............................................tt..................................................................	1	173	248	405
+5807	PF05979	DUF896		Bacterial protein of unknown function (DUF896)	Moxon SJ, Bateman A	anon	Pfam-B_5209 (release 9.0)	Domain	In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC [1]. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex [2]. Structural modelling suggests this domain may bind nucleic acids [3]. This family is also known as UPF0291.	21.50	21.50	21.50	22.70	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.07	0.72	-4.38	39	1638	2009-01-15 18:05:59	2003-05-22 13:33:07	7	4	1273	5	166	633	4	62.90	48	80.57	CHANGED	cchlcRINELA+KpK.spGLTscEptEQppLRpcYLcsFRsuh+splcslpVlDtp.GpDVTP-KlK	........chlcRINELA+KcK.s.pGLTt-EptEQppLRc-YlcsaRpsh+ppl-slK.l..l..D.c.GpDVTP-Kl+............	1	59	108	136
+5808	PF05980	Toxin_7	toxin_7;	Toxin 7	Moxon SJ	anon	Pfam-B_5254 (release 9.0)	Family	This family consists of several short spider neurotoxin proteins including many from the Funnel-web spider.	27.00	27.00	27.20	29.50	26.80	25.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.16	0.72	-3.91	30	91	2012-10-01 22:06:18	2003-05-22 13:43:09	7	2	7	4	0	96	0	33.90	49	50.57	CHANGED	GCLs+N+aCsshoGP+CCSGLpCKplSIhcohCl	.uCLhhsQaCNALus.+CCssapCKhls.h-uhCl.	0	0	0	0
+5809	PF05981	CreA		CreA protein	Moxon SJ	anon	Pfam-B_5258 (release 9.0)	Family	This family consists of several bacterial CreA proteins, the function of which is unknown.	25.00	25.00	52.10	51.90	23.20	19.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.69	0.71	-4.61	61	1188	2009-01-15 18:05:59	2003-05-22 13:50:15	7	3	1169	0	227	627	37	130.60	57	80.30	CHANGED	lGpVussa.hlGsD..Ill-AhcDPcVpGVTCalSpscsGslcthh..shhEDsS-uSIACRQsG.PIphs.....cp.c....pGEpVFpcppSllFKsL+VsRhaDtcpsoLlYLsYSc+ll-GSsKpSlSsVPlhssps	.................IGsVsTVF+hhGsDc+IVVEAFDDPcVcsVTCYlSRAKTGGIKGsL....GLAEDsSDAuISCpQV...G..P.Ipls.....D+lK.....pGEVVF++RoSL.lF...KoLQVVRhYDsKRNsLsYLuYSDKl......l-......GSPKNulSAVPlhshtt....................	0	42	100	159
+5810	PF05982	DUF897		Domain of unknown function (DUF897) 	Finn RD	anon	Pfam-B_8040 (release 9.0)	Family	Family of bacterial proteins with unknown function	21.40	21.40	23.80	37.70	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.99	0.70	-5.64	7	322	2012-10-02 17:06:44	2003-05-22 13:58:16	7	2	288	0	114	310	521	322.00	38	95.31	CHANGED	PslhFFhhGhlhuhh+S-LtlPtslspsLohhLLhsIGh+GGhtlpp...pslst.hlhshssulhLuhLlshhshhlLp+hsplcphDAhAhAuhYGSlSusTaAsAlohLpc.Ghsa-uahsAhlslMEhPAllsulhl...........................................................slhttp.s....sttshspsp.......t........tpllcEuhhssulslLlGGlhIGlloG.puh.hlp...sFh.slFpGlLslFLL.MGhpAuc+lt-Lpphu.hhllaullsPllhuhlulhlG.......hhs..GhssGshllhAVLuASASYIAuPAshRhulPcANPolYlusSLulTFPhNlhlGIPLa.hthAplhh.t	..........PhlLFFhhGhlusll+S-LclPtslhchLolYLLlAIGh+GGhpLsp...sslss.llh.hlsulhLuhllPlluahlLpthsphspsDuAulAuaYGSlSAsTFs...suluhLp...s....u..lsa-uahsshlAlMEhPAIlluLhL..............................................................hph..t.tp..s............t..t.....................h........................htpll+EshhssullLLlGGllIGhl...s...G.....p...Ghp.lp......sFhsshFpGlLslFLL-MGhsAuc+Lpc.L.p.p.s.G.h.hlsFullhPlltuhlGlhlu......hhh...shusGssllhulLsASASYIAsPAAhRhAlPEAsPolhlsuSLGlTFPaNlhlGIPLY.htl.uph...h...........	0	27	78	100
+5811	PF05983	Med7	MED7; 	MED7 protein	Moxon SJ	anon	Pfam-B_5278 (release 9.0)	Family	This family consists of several eukaryotic proteins which are homologues of the yeast MED7 protein. Activation of gene transcription in metazoans is a multi-step process that is triggered by factors that recognise transcriptional enhancer sites in DNA. These factors work with co-activators such as MED7 to direct transcriptional initiation by the RNA polymerase II apparatus [1].	25.00	25.00	25.10	25.00	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.84	0.71	-4.46	33	334	2009-01-15 18:05:59	2003-05-22 14:01:54	6	7	289	7	234	313	1	170.70	35	71.90	CHANGED	tsouhaP.PPP.ahchasppp............................................-lphhhPPs.....P..ppssYpsFGp.aphc-.............tlPs.L-spGlppLYsps...........................................ts+tpEL+KLs+SLLlsFLE.......................Ll.....slluhsP....pphcp..Klc-lphlhlNhHHLLNc.YRPHQuREoLIhlhcpQlcc++pplcplcptt-clcphlp	................................................................................suh.P.PPs.ah.+.aTscN.........................................................................ph.t.hh..PP............sP...hpssYphFGspapsc-...................hl..s.LEs..p.GlcpLaPtp..................................................................................hD++pEL+KLs+SlLlNFL-.......................Ll.......................slLhpsP.........................pphcc.....Kl-Dlph.LFlNhHHLlNc.aRPHQAREoLhhhhE.Qhcp+pppscchpcph-clpchl.p..........................................	0	79	128	191
+5812	PF05984	Cytomega_UL20A		Cytomegalovirus UL20A protein	Moxon SJ	anon	Pfam-B_5345 (release 9.0)	Family	This family consists of several Cytomegalovirus UL20A proteins. UL20A is thought to be a glycoprotein [1].	25.00	25.00	156.60	156.50	24.20	21.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.32	0.72	-3.81	2	14	2009-01-15 18:05:59	2003-05-22 14:13:27	7	1	6	0	0	20	0	101.60	84	97.33	CHANGED	MuRRlhlLuLLAVoLsVALAAP.QKpKRSVpsEpPusotsGsshT.ptplp.opsGphsDssE-...-YDVLI...-Go...pP..ppssEp.psptKEspp	MARRLWILSLLAVTLTVALAAPSQKSKRSVTVEQPSTST..NuD.NTTPSKNVTLSQGGSTTDGsEDYS.G.-YDVLITDsDGopHQQP.QEKTDEHKpEHTKENEK	0	0	0	0
+5813	PF05985	EutC		Ethanolamine ammonia-lyase light chain (EutC)	Moxon SJ	anon	Pfam-B_5363 (release 9.0)	Family	This family consists of several bacterial ethanolamine ammonia-lyase light chain (EutC) EC:4.3.1.7 sequences. Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia [1].  	23.00	23.00	23.10	29.80	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.61	0.70	-5.29	41	1134	2009-01-15 18:05:59	2003-05-22 14:16:49	6	4	1071	12	212	698	20	234.30	47	80.75	CHANGED	ssssts.sasc.L+phTsARIuLGRuGsu....lsTpplLcFphsHApARDAVasslDh..ttltttlps.........hsh.lplpSpAsDRspYLpRPDLGRcLsscuhtpLpspsstt..............sDlsIVlADGLSutAl..pppuhslLtsLhstLts....shpluPh.llspQuRVAluD-IGEhL........sA+hlllLIGERPG..LoosDSLGhYlTat.P+sG.psDA...........cRNCISNI.+.ssGLs.spAut+lshLlppuhchphSGVsLK	.....................s.hcs-shpcLRp.TsARl.shGRAGsp.....hTpslL+FhADHupA+DuVhptls.........c-hlcs......................shlpV+SpssDKshYLsRPDhGRR.LssEuhcsL+spssts..............sDVplVluDGLSosAI..psNhtplLssLhsuLct......tGlpluss.hhV+huRVtltDpIGElL........GA+lVllLlGERPG..Lusu-SLSsYh......sYs.P...+.....su.psEA............cRsCISNI.H..puGhP.....ssEAAuhlspLh+chLcpKtSGlsL....................	0	58	119	168
+5814	PF05986	ADAM_spacer1		ADAM-TS Spacer 1	Yeats C	anon	Pfam-B_1693 (release 8.0)	Family	This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases [1].	20.80	20.80	20.80	21.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.37	0.71	-10.35	0.71	-4.22	23	1464	2009-01-15 18:05:59	2003-05-22 14:39:08	9	158	90	0	835	1201	1	112.10	30	10.54	CHANGED	cslpGsFscpp.t.tGYhcllpIPsGAspIpIpEhphSs.....saLAl+sss..GcahLNGpatlshspp.hphsGoh.hcYsp..sss....t.EpLp..uhGPlpEsLhltlLsp..tspssul+YcahlP	..........................hlpGsaspst.......hG...Y...p.llpIPsGApp.Iplpph.phus...................................saL...A.l....+sps....GcahLNG...s.as...l...s...hs..tp...h......ph.s.G.o........h..hcYpp....sss..............thEplp..uh..G..P..hp-sLhl.......lLht..............t.....p.....sss...lcYpahl...............................	0	119	178	440
+5815	PF05987	DUF898		Bacterial protein of unknown function (DUF898)	Moxon SJ	anon	Pfam-B_5347 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function. Some of the family members are described as putative membrane proteins.	28.00	28.00	28.80	28.00	27.90	27.70	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.10	0.70	-5.55	83	1019	2009-01-15 18:05:59	2003-05-22 14:40:54	8	9	864	0	134	586	125	248.30	35	91.26	CHANGED	.pshphpFsGsu.uEaFtIWlVNhLLollTLGIYosWAKVRp+RYFYuNTplsGpsF-YpusshpllhGhL.lulslllhahlssphs........shhu..............hshhlhhhhhhPall.h...+uhRFphtpTsaRslRFsFpGshtpuhhshlhhslLs.sl....oLGlhh..........................................PhhhtphpcahhspspaGsppFshc...ssstshatshhh......shhlhlhhhhhhshhhh.hhs.hh.ht........................................hshhhhhhhshhlhhhhhhs...ahpsthtNhhhspspl........sthpF..pSslpstphhhlhlsN..........................................................hllhllTLG...................................LhhPastlR.hhR...ahscshsltu.s.slsplhusp.ppp..suAhu-t...huDsh	...........s..pphhFpGsu.tpaFhlhllshLLTIITLGIYssWuhh+hc+ahhtshplssp.htathpshtlhhshl.hhh.......................................................................h.hhh.hhhhh.hhhh....tshpaph..othpsl+h.htsthhthhh.h.hhh.hhhhh.......shhh..hh................................................................shh.......h.......h.hpt..h....G...ht.p.......htht.hhhhhhh.......hhhhh.hhhhhhhhh...........................................................................................................................hhh..hhhhhhhhh.........hh.st..phhhsthth........t.h..ph...tsphp.hthhhhhh.............................................................hh..hohG........................................lhhshh.hh.hhph.hpth.l.....sh.th.......tt.................................................	0	42	86	108
+5816	PF05988	DUF899		Bacterial protein of unknown function (DUF899)	Moxon SJ	anon	Pfam-B_5437 (release 9.0)	Family	This family consists of several uncharacterised bacterial proteins of unknown function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.55	0.70	-4.90	51	520	2012-10-03 14:45:55	2003-05-22 14:44:00	7	1	316	0	226	988	197	222.60	38	92.43	CHANGED	h..sp.slsoRpcWhtARppLLscEK-hTRppDplAspRRtLPh.Vcl-cs....YpF.....-sspGp.soLsDLFs.GRsQLlVYHFMF..uP...............sa.ppuCsuCShluDphsGthsHLpp+DlsLssVSRAPlscltsa+cRMGWp.hPWhSShsuD...FNhDFsVshstt.............................................................p-hPGh.SsFhRcs....GpVaHTYSo...........huRGh-slhusaphLDhTPhGRsEs.................htWhR+HD.......c...Y	......................................................slsspppWhsARctLLscEKt..hTRttDtlAA...pRRtLPh.VcV-.cs....Y.pF..........-uspG.t..soLsDL..Fp..G.RsQ.LlVY+..aMa.....uP..................sh..ctuCsuCShhs.Dph....G.tl.sHLpp+DsohssVSR............A............Plscltsa+pRMGWp..hsWhSot......s.us...FstDass.ht..t..........................................................p-hsGh..os.Fh.R............-s.....sp.VaHT..Y.S.o...........huRGh-tlhssashLDhsPhGRpEs................h.WhphpDt.......................................................	1	55	114	164
+5817	PF05989	Chordopox_A35R		Chordopoxvirus A35R protein	Moxon SJ	anon	Pfam-B_5472 (release 9.0)	Family	This family consists of several Chordopoxvirus sequences homologous to the Vaccinia virus A35R protein. The function of this family is unknown.	18.80	18.80	19.10	19.30	17.70	18.70	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.10	0.71	-4.66	9	54	2009-01-15 18:05:59	2003-05-22 14:47:44	7	1	39	0	0	44	1	157.80	49	96.24	CHANGED	.shhsllTshGVlpIpscph.+sh.sDLGI.sl..l-hlGPYtluolplp.lssshlpppslpcCYlutNGhllpCScpspLshPlpplasuaho+sshllChDc..h.+Lhl-sphQPFYlhoShslhcu..cIlEVYNLYpcGDYphIlNPSssFLphLscpsshCLoDpsGWlIlDu.Ksc	...MDtshlITshGlLpIsD.....Tlh-DLsI.oI..hDhIGPYlIGsIchspIs.lc-IchuDMpcCYFuhpGpllspspsphhphslhpIpsAYho+ssh.l.IsCDh..chhL.lcspaQP...FalhsulslhsA..pIlEsYNLYptGDYphIlNPSsshhhpL..ppshCloDGsGWhIlDs.Ksp.....................................	1	0	0	0
+5818	PF05990	DUF900		Alpha/beta hydrolase of unknown function (DUF900)	Moxon SJ, Bateman A	anon	Pfam-B_5475 (release 9.0)	Family	This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.76	0.70	-5.04	13	508	2012-10-03 11:45:05	2003-05-22 14:51:33	7	13	338	0	213	832	107	214.60	24	44.33	CHANGED	spsutpshlsscltpsts+clllFVHGaNssF--AlhRhAQIsaDhs.......................hsu..ssllFoWPSpup...lhs.............YsYD+E..SssaSRsALEchL+hLAps........sscclpllAHSMGsaLshEuLRQluhcst..................shss..KlspVlLAAPDlDl.DVFspQhp...........shG+.s........chTlasSp-DRALp.lSphlsGsssRlGshsss.....pptltstGl.....slVDloclcuuDh.lNHspFussPpll....pLlusR	................................................................................ts..........................t.ccl...h..l...FlHGa.N...s....s....a...p.......-.....u........h..h+....h.A...Q.l...s...p...s.......t................................hps.....ssll....Fo..W...P...S.p..u..s.......h..hs.......................................Yh..h..D.+c......us..p..h....o..pss.......L.t....c......hL....p.t.l.....s..ps..........................................s...scclpllAHSMGshlshc...u...Lc..phshpst...................................................................th.t....+lss.l.lLs.u.P..Dl.Dh..-..s..Fp.ppht..................th.s.p.t.........pholasSpcDpALt.hSp..h..l........t....u..s....h.....R..lGt.hss............h.......tl.............hlDh...sph..ts.........t.....h.t..Hs.haht....h............................................................................................................................................	0	53	129	169
+5819	PF05991	NYN_YacP	DUF901;	YacP-like NYN domain	Moxon SJ, Bateman A	anon	Pfam-B_5522 (release 9.0)	Domain	This family consists of bacterial proteins related to YacP. This family is uncharacterised functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind [1].  Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA [1].	24.60	24.60	24.90	25.40	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.22	0.71	-4.50	69	1318	2012-10-03 20:43:45	2003-05-22 14:58:10	6	12	1288	0	277	838	38	157.20	34	60.56	CHANGED	LlVDGYNlIsu.....WscLcclt.cts........L-sARppLl-hLssYpu.aps.hclllVFDAphltG.tpchpph....tslpVlaTc-scTADsaIE+hstpltp.t.....ppVhVsTSDtspQhhlhupGAhRhSuc-hhp-lppsppplp.p........chpp....tpp..ppphhp.......ptlspchhcphcchRc	.........................LlVDGYNhIus......WspLpplt.....cts....................................L-...pARppLlctl......u.s.Ys..u..hpu..hc.......lllVFD.AhhstGh..p...p.p.h.ph.....slcVlF..T..+E..s..E...TADsaIE+hstc.hts.t.............ppltVsTSDhsEQhs.l.a.upG.AhRhSu+ELhpclppscp.plp.p..............phpp....hpp....pp.hht..............h.spc.htphcchh.........................................................................	0	115	208	250
+5820	PF05992	SbmA_BacA		SbmA/BacA-like family	Finn RD	anon	Pfam-B_8139 (release 9.0)	Family	The Rhizobium meliloti bacA gene encodes a function that is essential for  bacterial differentiation into bacteroids within plant cells in the symbiosis between R. meliloti and alfalfa. An Escherichia coli homolog of  BacA, SbmA, is implicated in the uptake of microcins and bleomycin.  This family is likely to be a subfamily of the ABC transporter family.	20.00	20.00	20.40	20.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.07	0.70	-5.23	10	817	2012-10-02 13:23:42	2003-05-22 14:58:56	7	3	763	0	82	1485	1772	298.70	62	77.94	CHANGED	s+cWQhWSlLGTulILFshaFsVQluVtlNsWYGPFYDLIQcALusPsulThs-FYpulhsFhtIAhluVsluVlNsFFVSHYlFRWRTAMN-YYhu+WspL.RHIEGASQRVQEDTMRFuplhEsLGlullculMTLIAFLPlLasLSspVshLPllG-lPauLVhAAllWSLhGTlhLhlVG..IKLPGLEFsNQ+VEAAYRKELVYGEDc.ssRApPtTLcELFssVR+NYFRLYFHYhYFNluRlhYLQsDs.lhshllLsPoIVAGplTLGlMsQIoNsFG+VRGSFQYLlNSWoTIlELhSIYKRLRuFEupIp	...............................................................................................PH+WQ.h.W.S.IL.G.o.u..L..I..I.Fl..T.WF.h..V.p.V.uVAl..NAW...Yu....PF...Y.DLIQ...s...A...L.......o.......o...P.......c....p.......V...o.......l....pp....F......Y..p.....p....l.u.............VFLG.I..All.AV.lI....u.V.L.....N............sF...F............VS.H.YV...FR.W....R.....T......A.....M...........N...........E...........a....Y.........M......u.......p.......W.............p..........p..........L.........R..............H..........I..........E........G.......A.........A...........Q............RVQEDTMRF...A............o............T.......L............E.......s............h............G.....V.....S.......F....I.sAlMTLIAFLPVLlTL..S..s...H..V..s..c...........L...........P...I...l...G....a....I....P..au....LVhA..AIlWSL..h...G.TGL..L.A.V...V.G..IKLP.G.LEF+NQ.R....V.E.....A.AY..R.........K..E.L........V........Y........G.E........D........D........A........s.........R........A.........s.........P.......s.....T........V.R..E.....L.....F...o....u...VR.........+.......N..Y...F...R...L.YF..H.Y.......h.......Y....F.......N....IA.......RILY.......LQ....V..D.N.....l.......FuLalLFPS.IVA...GsITLG.LMoQITNVFGQVRG...uFQYLINSW.....TTl.......VE.....LhSIYKRLRuFE+pL.c..............................................................	1	16	35	59
+5821	PF05993	Reovirus_M2		Reovirus major virion structural protein Mu-1/Mu-1C (M2)	Moxon SJ	anon	Pfam-B_5584 (release 9.0)	Family	This family consists of several Reovirus major virion structural protein Mu-1/Mu-1C (M2) sequences. This family is family is thought to play a role in host cell membrane penetration [1].	25.00	25.00	61.20	54.00	17.70	17.50	hmmbuild  -o /dev/null HMM SEED	674	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-13.03	0.70	-6.71	2	56	2009-01-15 18:05:59	2003-05-22 15:04:45	7	2	25	36	0	67	0	614.20	48	98.52	CHANGED	GNspo.VpThNlTGDGNsFpPou-hoSTAsPulsLpPGhLNPsGh.WhslG..TSVso.suL...........................AlVs.p.t.hshVsEthhtsFoKA.hslph.p.hhpth+shsss.hhSshhThsssYVGsoAtpALsN..pps.VhhsThQsM.lp.oItAth+slthWp.cLcsA.ThLssslshGpsSCshpSllthhcD.LP.DsLhhpYPpEhhsshh+R.sulp....Dsp.sss.scslstVAuuh.AsoupsssL.tpSphhpQAhshhsut-.-lItu.sPlPssVFs.s.tPtsYpsthlK.--ApW...Isch.sosh.hpshs.oGssatlpL..GsTRVlshsthhs.hhsLDluGp.h..-Ts.D.ssphsuFllhQoplPhp.hTsAupIsthTVVshsth.A.s.uhss..QshhshhpLthsaE.Eplsth.P.h..YhLuTFl.sushosoNhopPslhDuLLThoPl.htEsThKGtVVstlVPAplhus.TsEplsuuLsNDAhhhh.s+hsKlAp........A.KhDDsAsss.hS..uV....QhtlSQltps.ss....P..lL.+hApRAhphFlusPShhlp.uhPVLopps.h.ALspGVtTuLRTtSLutGVpsAspKLpuppSlpshpQuFhDpluohaPu.	...........GNAoSlVQshNlpGDGNhFsPSAEToSoAVPSLSLsPGhLNPGGhsWhhIssphssosPuuLRhMTotDlsphu..shsNSoGhlPopuhh.sss.s.c.EsLsVlT-HAIspFsKhpMAhEhsR-aLDtptVsstSsphpsalsYVDCaVGVSARQAhsN.FpppVPVITpoR.s..ahs.ShQshLpsLs.WEhDlRphhTlLPTssshGcloCcM+SVVphlD-QLsDsSLCRhYPcpAAsAlA+RNGGI+...Whssspsps.u.AsNslAASshushAsssPLsEKSstsEpuMcLVsssslDIlsSpsPlsuSVauhsscPpsYNlRTL+l-EAhWLR.h.tosshshphp.hssppuTphHh.L...ptGopVlNL-QhusMhF.lsluGKsYK.cssa...DPss++lsllVhQSKIPFEtWTsASQIsuIs...VutVplaA.t-SShss...ppIIupTSLuYhFERETlsssssElNhYLLsTa..sss.osss.s..P..DsWDulhTloPLouGpVTlKGssV-pVVPuDLlGuYTPEuLsAALPNDAuhlhts+AsKlAc........AIKh-DDussDEsSPhSsPIQG.LAlpQ..L-T..s..t..G.sRhhpP...uhLp+lASRAhphFlGDPpoILpQusPVLpDsslWsuhsQGV+sulRTKSLSAGV+oshsploAspSlQsW+QGFLsKlpshF...............	0	0	0	0
+5822	PF05994	FragX_IP		Cytoplasmic Fragile-X interacting family	Finn RD	anon	Pfam-B_8072 (release 9.0)	Family	CYFIP1/2 (Cytoplasmic fragile X mental retardation interacting protein) like proteins for a  highly conserved protein family [1].  The function of CYFIPs is unclear, but CYFIP interaction with fragile X mental  retardation interacting protein (FMRP) involves the domain of FMRP  which also mediating homo- and heteromerization [1].	20.50	20.50	20.60	21.30	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	820	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.27	0.70	-6.76	9	299	2009-01-15 18:05:59	2003-05-22 15:10:11	6	10	123	1	179	271	13	647.30	51	67.18	CHANGED	scscclhsls.puLplLSphsshVhEh.huaKlhsPss.p...sNctsstt............spcYERAsRYNYoctE+huLlpllAhIKuL...pplhtctEollsptlpcsI.spLQ-FspppLcEsl++ss+....KK-hlpsllpsl+shhsDa.suhc.tpcsthpsc+c........pst.clpl...........L.hlRo.LpSLlssc.thsc+p...hppphcupplpsIctFhpcShaastLLshspsLppssDLSpLWa+EaaL-ls.........................+RlQFPIchShPaILocalLpsp-.PuLh-hlhYPLslYNDuAthALhph+pQaLYDEIcAEsslCh-phsaclu-psFshh+phuushhhDKphhsphpp.th.h....pP..........susRapsLLpQp+lpLLGpsIDlstLluQRlNtthhcpL-tAIsphEupslpulltl-tLl-l.+lTHpLLucah.slssF-shhppAppsso..u.pu+IhlHl.....a.cLshDhlPsYsapuss.R.......h..ttt.tRccss..t.ha.husKslstuasshhpthssFlus.HF+slsRlLshpulsllhpplLc.....hlpsshtsalpshhphhspls+l..PhhshGs.ushshFptplpshlpas-l+.clhpshRplGNslhFsthl-pAL.hpcpstshhpAhshps.hsps...hpcsp-..s.....hppLcphauhLp.hs.l.................s-lhh..phpsshulhc.lLpchcsFl.s.........htss..ssulhsl-oss...pFttlWSslQFlaChPhs.ss-h..........ss.phFG-GlhauusslIsLhsQpc+F-slshChHllplpc....ssscDch.+hlslp+hl-phppaplhssphFtlhsp	......................................................................................................................................................pthh-lsLpGlQLLSpWoutlhEh..hoWKLlHPocch.....pNc.cCPsp................AEEYERATRYNYosEEKhAhlElIAMI....KGL...pslMsRhEolhspAIRpslYutlQDFsQhsLc-PLRpAh+....pKKshl................sll.slRcshsDW.t..u.hc..s....s-ssh+ucK-s..........psshplplsphss..................................................................................tssssQLYMlRThlESLlu-+.sss....K...+...s.............h.+p.pl-..u...hl.tl-pFacpSaaasaLlshS.csLppssDLSQLWaREFaLEhT........................t+RIQFPIEMShPWILTDHILc....op-.................suhhEhVLYsLDLYNDSA.aALstFp+QFLYDElEAE..V...NLCFD...Q..FVaKLu..-pIFsaYK....hAuShLLDK...+h+.s.-sps.uh.h....hP.....................ssRY-.o.LL+QRHVQ..................LLGRSIDLN+LIoQRlssshh+ul-.AIsRFEupDL.o.uIV...EL-hLL-lNRhoH+LLscah.sLDsF-uMhcEANHNVo...............u....PaGRITLHV.....FhELsaDFLPNYCYNuuTpRFV............................+s.hshs....pt.....pR-K...sp..sp......a..laGSK...........LNhAapphhs.YpsFlGsPHhpslsRLLGYpGlAllhcpLL+.h....c.llps...s...l...h...pal...csL.h.psMPK......C+L..Pph-YGSsGlLpaaptpLpslhpYs-lKo.hhpshRElGNsllFshLlEpuL.s.cEssDllpAAP.FpsllPcsh.......hKc...s..p..c.p.sp...........hp+L-spauslp..hss.lp+hus.p.............................................................phthA+-uDLLT+ERLCCGLShFEslLsRl+saLpcs.....................lWp..G.s..P.sN.GVhclD-Cs...EFHRLWSAhQFVYClPss.spEh.........................os.EphFG-GLpWAGC.lIsLLGQQ+RFchhDFsYHlL+Vp+.......................Du+Dc...lc..sl....L...c...+....hs-RlR+aplLNsplhslL...................................................	0	74	97	142
+5823	PF05995	CDO_I		Cysteine dioxygenase type I	Finn RD	anon	Pfam-B_8006 (release 9.0)	Family	Cysteine dioxygenase type I (EC:1.13.11.20) converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate  production.	21.40	21.40	21.90	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.97	0.71	-5.10	8	920	2012-10-10 13:59:34	2003-05-22 15:12:25	7	10	728	11	390	865	131	155.50	22	77.31	CHANGED	Mp.........pssshpssossshlspLtphhpppthsVsphttLhpshpsshs-Wt...hhhhaDtspYTRstl.tGssch-lhLlsWsPGpuoslHDHusStGshplLcGpLpEotashsct...............h....shhspphhhpsGsshhpspttlH+l...........tNsSsscsAVSLHlYhPPhsshsha-pp	......................................................................................................................................................................l...th................ph......h........s.......p.p...Y..tpphl...ps.........s..s.............c..hs.l........h..l..ls..W.sPGps..o..slHD..Hsssash.hs........lLp.G.p..l..p..............E..p.tap.hspp.....................................h......h.s..p.p.h.h...h.t.st..s..s...h.....h........s..t.....ts.l.Hcl.......................tss.s..t..sp...s.ulSlHlY...........................s...........................................................	0	107	212	322
+5824	PF05996	Fe_bilin_red		Ferredoxin-dependent bilin reductase	Moxon SJ	anon	Pfam-B_5667 (release 9.0)	Family	This family consists of several different but closely related proteins which include phycocyanobilin:ferredoxin oxidoreductase EC:1.3.7.5 (PcyA), 15,16-dihydrobiliverdin:ferredoxin oxidoreductase EC:1.3.7.2 (PebA) and phycoerythrobilin:ferredoxin oxidoreductase EC:1.3.7.3 (PebB). Phytobilins are linear tetrapyrrole precursors of the light-harvesting prosthetic groups of the phytochrome photoreceptors of plants and the phycobiliprotein photosynthetic antennae of cyanobacteria, red algae, and cryptomonads. It is known that that phytobilins are synthesised from heme via the intermediary of biliverdin IX alpha (BV), which is reduced subsequently by ferredoxin-dependent bilin reductases with different double-bond specificities [1]. 	25.70	25.70	26.20	26.30	25.30	25.60	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.30	0.70	-4.88	62	239	2009-09-10 22:50:27	2003-05-22 15:14:14	7	4	127	41	111	271	579	213.70	26	84.15	CHANGED	hpplppthpph...slpPh.slssshpthpuphstp....phhIpshhapstthR+l+lptscsGsuLplLssVhaPs.pa.DLPlFGsDl..Vshsst.llA.llDlpPl...ppc.ta.pcahpsLtslh.........ph.shhspspplPt-up.aFSPhhlasR.....ssspp.csthhsthpcYLplahphhppApsh......sss.p..................htclhpuQppYspaptcpDPuRtlLp+hFGppWu-cYlcphLF-	........................................................t...h.t.htth.thtsh..lsttht..hpuphttt....phhlpshsaps.phR.+.h+hthhcsGpshplLpsVhaPps.........pa.D.......LPlFGsDl..lshsst..l.hs..hlDlpPl.......tpptp.h.....ppYhp...tLtsLh..........p..t...h..h.s..pspclst.up.hFS.shslasR..........ssstp.....tppthhsthpcY....Lphahp.hhpp.up..........sstp..................................................................................htphhpuQppYsphptc.pD.s+tlLp+hFGppWu-calpphLFs...............	0	31	72	102
+5825	PF05997	Nop52		Nucleolar protein,Nop52	Finn RD	anon	Pfam-B_8003 (release 9.0)	Family	Nop52 believed to be involved in the generation of 28S rRNA [1].	19.70	19.70	19.90	19.90	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.44	0.70	-4.91	35	436	2009-01-15 18:05:59	2003-05-22 15:24:39	7	5	303	0	284	427	4	187.10	27	44.25	CHANGED	tphths+pLAus-cpsR-+ulc.pLppalsppspp..........sch-hhKlWKGLFYshWhsDKPlhQpcLAsclu.pLlpshpssp..................sthtFhpuFhpoMs+EWssID+aRlDKahhLhR+hlppthphLpcppWct...phlpchhpllhcp...hltsps......hspGlthHlh-lal.....-ELtclhtt........................................lsspslhtllcPFhpl.htpspschLhp.....plpppla..cpl	..........................................t....hhppLAus-phhRppulc.tLppaltsppth..........................st.-hhKlWKGLaYshWh.pD+P..lhQppLupplu.pLlt.sh.stt...................................s.hhFhpsFapohs+EWt.uIDphRlDKahhLlRhhltt............shp..h.lpp............p..................t.Wpt...............phlpthhphh.pt.....hh.sps...................stGlthHhh-lal.....-ELtcsht.t.............................................................................httt...hhlpPahph.htps.sphlhp.phtptlh...h...................................................................................	0	93	146	224
+5827	PF05999	Herpes_U5		Herpesvirus U5-like family	Finn RD	anon	Pfam-B_8027 (release 9.0)	Family	This family of Herpesvirus includes U4, U5 and UL27.	25.00	25.00	37.00	36.00	18.60	17.00	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.62	0.70	-5.89	14	74	2009-01-15 18:05:59	2003-05-22 15:37:14	6	2	28	0	0	71	0	432.70	41	71.31	CHANGED	lcsLpFh--hsthaptlTKhsAlGpYussplhshs.p+sTlutahRhLsEhhstLahphcthh...p.clcsEshtpLtshLsshhspthcssh.spstl..FacscaFtphpssLh.hatlLCuCsEC...R.phFhhatthsht.......++s......stsl+lpshsth..ss.............hcLPhh.HLsttpshsLpsplu+DLGh.Sh..IppslEcp+.LPI.shs.pluhs.pc+slLplhoNIVhhLFllppl+phIhpELshhhchasctltcLphsh........................................Etth..hLssssshpshphhs.......hhc+l...+...hthlpssusp.phhpphp-slchuFpls.atphs.......hhhHhhhltp.....................................ssh-...LstssNLl.aF...tst..p.h.hl.t...slp-s.Ls....s........T+...hhsG...........shshhhpGhpaFt.......................chc.+ththKhhslc+ht.chhh	...................lc-hpalPEhScuuKpIuhAlATGQYsVsoLlsY+.shGTho+YLRpLCshs--LahRL-Gsl....sLhL-sE-+ElItRhLPsslC+tLslcY+sp+sAh.FF+soFhsRsEuAL+clYusFCpCG-.s...R..cthspststsus............................ccus........hS.usssSpascL..Ecs-.LRLppstp.................LGsh+LPAIRHLTAs-ssRVpsuVuRDLGF.uc......WSpoLscca.FLL.PsGh.usus.Pc+GYAhYLASNsVLsLplIRlLRssIR+EasAslRhLoG-Vp+LlRhh.........................................cspu..ALlRpuhuQs.sppR.......tLpRh...+..h.c-lcRhphspssFlcsFCDaL-lspRIPDY+ulS.phpREhLhLHsF+LRR.hhs................................ssosE...ss+spRLlha..l++Gcs.spDtstL.phuosLSDsELS....N........s+...p+As.....s.........lVuhsssulch...........................csHhp+h-RLaVRRhRs+cV.s.................................	0	0	0	0
+5829	PF06001	DUF902		Domain of Unknown Function (DUF902)	Yeats C, Bateman A	anon	Pfam-B_3539 (release 8.0)	Domain	This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein, which is an acetyltransferase that acetylates histones, giving a specific tag for transcriptional activation. This short domain is found to the C-terminus of bromodomains. The 40 residue domain contains four conserved cysteines suggesting that it may be stabilised by a zinc ion. In CREB this domain is to the N-terminus of another zinc binding PHD domain.	25.00	25.00	28.50	28.50	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.39	0.72	-3.82	8	198	2009-01-15 18:05:59	2003-05-22 15:46:14	8	23	88	31	105	157	1	41.80	80	1.84	CHANGED	PVMpthGYCCG+KhsFsPQsLhCYGKpLCTIsRDpsYasYps	....PVMQSLGYCCG.RKhEFSPQTLCCYGKQLCTIPRDAsYYSYQN......	0	30	41	68
+5830	PF06002	CST-I		Alpha-2,3-sialyltransferase (CST-I)	Moxon SJ	anon	Pfam-B_6887 (release 9.0)	Family	This family consists of several alpha-2,3-sialyltransferase (CST-I) proteins largely found in Campylobacter jejuni.	23.10	23.10	23.10	24.80	22.00	23.00	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.95	0.70	-5.14	7	193	2009-01-15 18:05:59	2003-05-22 15:52:33	7	2	103	15	9	148	3	226.00	41	89.60	CHANGED	.KslIIAGNGPSLKsIDYphLPK-aDVFRCNQFYFED+YaLG+cIKuVFFNPsVFhpQYaThppLlpNsEYpl-pIhCSsh.Nhshl-spp.hc......hptaFsssp.Gap.hlKpLctF.s.alKY+ElY.spRITSGVYMCslAlALGYK-IYLsGIDFYtsstshYsF-spppNlhphhsshpppcsp..hHShphDlpALphLpKhYtlplYuLsPsS.LspahsLus...shs.sFhl.cK.psYhpDILlssp.s..ph.t.h.hK+.+ltpNlh.hL.h+DlLch.p-lK+hhKEK	..................K.lIIAGNGPSlKpIDYSh.LPpDaDVFRCNQFYFED+YaLGKchKtVF..aNs.hh.pQhhThhpLlpNpEYchE...Ihhosh.Nhtphct..c.hhc...........................h.paasssp.uas.hhppLct.F.s.ahpapch..a....sp+hToGlYMhssAlAhGYK-IYLsGID..FY........pphs.ahFcpppppl.p....ht.ppptp..hHoh..p...hDlpAL.hhpcp..YtlplYslsPpS.Lspah.LuP........p.s.tFh...cK...shhp.-hlhss....tph.........tp......p....h...p...h.....................................................................................	0	3	7	9
+5831	PF06003	SMN		Survival motor neuron protein (SMN)	Moxon SJ	anon	Pfam-B_7026 (release 9.0)	Family	This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs [1]. 	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.80	0.70	-5.28	3	460	2012-10-02 16:56:36	2003-05-22 15:59:04	7	15	193	8	279	592	1	149.70	19	54.01	CHANGED	GQSDDSDIWDDTALIKAYDKAVASFKNALKNEDCopPuEs-EpNPGsKRKNNKKNRSRKKCNAAPLKcW+VGDSCNAVWSEDGNlYoATIoSIDtKRGTCVVsYTGYGNcEEQNLADLLsPsoD...s-pt.pEsNlNETEaSTDESDRSS+SHcs+s......pNpspu+sS.WNsRFPPsPPPsPPGF....GRHGEKhc.shPPFLSGWPPPFPsGPPMIPPPPPMSPDusEDDEALGSMLISWYMSGYHTGYYLGLKQGRMEAAluKcuHpK	....................................................................................................................................................................................................................................................t......t..W.p..sG-pC.Ah.a.tpDG..p...h..Y.ApIttl..s...p...tt..ssh...lhatsY.sNt..E.......hts...lh...........tt.............t....t......t........................................................................................................................................................................................................................................................................................................................................................................ptt.....................................................................................................	2	91	127	207
+5832	PF06004	DUF903		Bacterial protein of unknown function (DUF903)	Moxon SJ	anon	Pfam-B_7037 (release 9.0)	Family	This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown.	21.10	21.10	21.60	28.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.13	0.72	-4.44	30	1612	2009-01-15 18:05:59	2003-05-22 16:01:35	7	1	599	28	138	407	4	49.80	54	68.54	CHANGED	shVlsppDGppIlTpsKPchDc-oGhhpYcchs.GcctpIN+DpVpplpEh	..sYVMpTpDGRpIlTDGKPplDsDTGhlSY+Dtp.GNppQINRsDVpphlEh..........	0	10	29	85
+5833	PF06005	DUF904		Protein of unknown function (DUF904)	Moxon SJ	anon	Pfam-B_7038 (release 9.0)	Family	This family consists of several bacterial and archaeal hypothetical proteins of unknown function.	30.00	30.00	30.10	30.00	29.90	29.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.42	0.72	-3.68	35	833	2009-01-15 18:05:59	2003-05-22 16:04:09	7	2	821	4	109	271	20	75.10	62	94.17	CHANGED	MshElL-cLEpKlppAl-TIsLLphEl-ELK-cptt.t.......ptpppL.pENpcL+................pEpssWpcRLcuLLGKlcpl	.....MSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNssLspEs........QphpcpREpLE+ENppLK................cpQsuWQERLpALLG+MEEV..............	0	15	45	82
+5834	PF06006	DUF905		Bacterial protein of unknown function (DUF905)	Moxon SJ	anon	Pfam-B_7072 (release 9.0)	Family	This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in Pfam:PF03646.	22.30	22.30	22.30	22.50	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.46	0.72	-4.60	10	520	2012-10-01 21:18:35	2003-05-22 16:06:47	7	3	290	1	14	219	2	65.50	62	87.11	CHANGED	LhsLP-GPFTRcQApA...VuAsYpNVhIED.DQGsHFRLVVR...ss-GphVWRsWNFEPsAGchLN+YIpopGIh+	...........h.hLP.-GsFoRcQA.A...VsstYRNVFIED.DQGsHFRLVlR....s-GphhWRsWNFEssAGhhhNphlts.GIl+......................	0	2	4	9
+5835	PF06007	PhnJ		Phosphonate metabolism protein PhnJ	Moxon SJ	anon	Pfam-B_7179 (release 9.0)	Family	This family consists of several bacterial phosphonate metabolism (PhnJ) sequences. The exact role that PhnJ plays in phosphonate utilisation is unknown.	25.00	25.00	54.90	54.80	24.20	17.80	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.78	0.70	-5.62	32	691	2009-01-15 18:05:59	2003-05-22 16:13:10	6	3	653	0	123	424	122	272.60	76	95.83	CHANGED	psssYNFAaLDEpoKR.IRRulLKAlAIPGYQVPFuSREMPhshGWGTGGlQlThulIGtsDsLKVIDQGuDDosNAVsIR+FhppTs.GVsTTc+Ts-ATlIQTRHRIPEpPLpcsQILVhQVPhPEPLRhlEPpEscs+pMHA.t-YuhhaVKLYEDIs+aGcIspoacYPVhVNsRYlMcPSPIP+FDsPKhcpssAL.LFGAGREKRIYAVPPYTpVcsLsF-DaPFclppaps.......sCuhCGuocSaLDElhhcDpGs+ha...CSDoDYCpp+htptpt	.........sh.sGYNFAYLDEQTKRMIRRAILKAVAIPGYQVPFGGREMPMPYGWGTGGIQLTASlIGcsDVLKVIDQGADDTTNAVSIRpFFpRVo.GVsTTERTs-ATlIQTRHRIPETPLoEDQIllaQVPIPEPLRFIEPRETETRpMHALEEYGlMpVKLYEDIARFGHIATTYAYPVKVNGRYVMDPSPIPKFDNPKMcMhPALQLFGAGREKRIYAVPPaT+VESLDFDDHPFoVQpWD-.......PCAlCGSscSYLDEV.Vl.....DDsGsRMFV..CSDTDYCcQppptt.pt..............	0	22	65	90
+5836	PF06008	Laminin_I		Laminin Domain I	Yeats C	anon	Pfam-B_1925 (release 8.0)	Family	coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [1].	30.50	30.50	30.70	30.60	30.20	30.40	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.71	0.70	-5.07	9	327	2009-01-15 18:05:59	2003-05-22 16:14:52	9	117	70	0	165	325	1	235.80	22	9.88	CHANGED	p.......lhuls.hTGsh.tsh+l.tphcshpppLpphhtthstpppplpsh-pt.lpsLtp-s-sLtccsspshspupplppsscpThppApsLtttIcpltpslpplhpphtthsp...pt.pssspslppthtpup+hLpplRtR.s.hpp.ppsA-t-hctAptLLsclpphhpp.pt-spuLhpslpcpLscaps+LpDhcphLccAtspsp-ApcLsttsptshp.thpcpppclpcppphhscpLssupshLtpssthLpthspsh	....................................t...p....l.sls..sush....t.hch.hphps....hpp.pLpphhsthp.......tp.plp.h-pp..hpsL..p-hc..pLtp+s........p..ts.ttcupp.h....tpssppshppAppL.p.lpplhpp....lp...t..l.pp.h..thst....tpphss..tplpphhtpspphlp-hRp+...s..httppp.A-tEhptAp....t..LLpplpphhtp.ptc....sp....sl..hps...lpcpLscaps+LpDhpphLpcA..hsps+pAp.....plsttNptphp.thpcphpplpptppphpphLppups.Ltpsp.hhp.hpp..h...............................	0	21	33	81
+5837	PF06009	Laminin_II		Laminin Domain II	Yeats C	anon	Pfam-B_1925 (release 8.0)	Family	It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [1].	27.90	27.90	27.90	28.20	27.80	27.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.75	0.71	-4.42	8	340	2009-12-23 11:36:11	2003-05-22 16:21:42	7	125	84	1	171	348	0	130.80	28	5.22	CHANGED	uKphAscAscosspVLctlpslspsltphppsluplsssht.hpt.hp..stspsltsAssuV+sLpcpAspLl-+Lcslcphcss.t.....LScNlucIKcLIuQARctAspIKVuspFcscoslcl+s.pcssshsshTsl	........................................................................KthsppAscpstpVhptl..pslp.pslpp.h.....pps...hsphpss..............t...........s.hspsl...s..sA.ss....s..VpsLp...p..phsp.Lhc.KL.csl.......c....php....s............locsIscI+EL.IsQARct.As.p..lpVuhpF.s..Gpsslpl+s..shsshpshTs..............................	0	24	38	93
+5839	PF06011	TRP	DUF907; 	Transient receptor potential (TRP) ion channel	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_5564 (release 9.0)	Family	This family of proteins are transient receptor potential (TRP) ion channels.\	\	They are essential for cellular viability and are involved in cell growth and cell wall synthesis [1].  The genes for these proteins are homologous to polycystic kidney disease related ion channel genes [1].	28.50	28.50	28.60	28.50	28.30	28.40	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.48	0.70	-5.91	75	554	2009-01-15 18:05:59	2003-05-22 16:36:52	7	15	147	0	432	554	9	419.00	23	50.82	CHANGED	ulsassAsluGlullsouhsushut..............................u.......ssAscl......ussshslFtYaQshuhsGMhuVs.hPslhtuaspNFtWShGlIphsFhQphhsha....hpuTGG............ssoshhsshtsh........sh.s........................................................R..............th.h...............................................................t.s...ss..hhhp.......GlpRluhhssIcposhahTu.hhhallhlhhlslhlhhhKhhlclh...................h.+tthh.psschtpa......Rppah...slltG...slhRllh.lhas.lsllshapFspsD..............................................................................................................S..suslllAslhlllhhullsas................................................sh+llhhu+cphphhpss..uhhLYsD.......pslp+aGalYspa+ss.taaahlsslsYhhl+ulhIuhsQs..sGhsQslslhllEhlhllslhhhRPahsKpo.NhhNI.sIsllphlsslhhlhFsshas.stsspulhG.llhhllpAshslhLhlhl...llssllslhp+sP.cs+hps..........................................hpDsR....sSFhppts	.......................................................................................................................h.ltasssslsshullsoshhu.hhu................................................s....sshsph.................usshhs...lhtahQthshhGhhuls.hPshht........sa.spshtW.Sh.G.ll...phs...h...hpph..hs.ha...tsoGG.....................sss..h.h.s..tsh.........................................................p........................................................................................t..............hhh.........Glpphu..hhslptsshh..hTu.hhhah.lhlhhhhhhlhhh+hhl.chh......................................................................................h..+hthh..tpph.ta......Rp.pah...sh.htG...slhRllh..lha..hs..lhshap..h...st...ts......................................................................................................................S........sushllAsl.hl.hh.hhshh.s.ah..............................................................sh.phhhhs+.p.ht..ts.......shhLasD................thlp+aGhlY.spa+ss.taaahlshlhahh.l+uhhluhsQs................sGhs..Qslslh.llEhhhllhl.hhh+Pa...hs...+po.Nhhs.l.hlsslph.lsshhhlhF.ss..h...s..sthsp.....sh.....hG.hlh...hllpu...shslhL..hlhh.........hlpsh.ht..lhpc.ps.chphp....................................t..............................................................................................	0	105	229	366
+5840	PF06012	DUF908		Domain of Unknown Function (DUF908)	Yeats C	anon	Pfam-B_6534 (release 8.0)	Family	\N	25.00	25.00	26.40	30.30	21.60	24.50	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.77	0.70	-5.13	25	318	2009-09-11 20:50:55	2003-05-22 17:01:12	7	40	239	0	225	312	1	287.90	26	8.83	CHANGED	sccLllslLcFophLLEpCsNRslYsSh-.+LssLLsosshcllhusLcllhthupRh..tpt.....st.h..p.hppp.th.hp+lhplAtsastssh..........................................................sstscthuLschh...........tccph.pphsplphpYYhss.......................................................t....+pstttts............................t.ttpsssspsuhphhclsppphpppslp-lhcpthpp..lP............pchpa-hhp+lRhs+uhsssph.....RppllshRlhAIuslshlh...spststs+lhph-s.......hhppLs-Llphs...s.....plspplpshulpuLpulup..++sphss........llssLusslsHGlLhpllRphlspl	......................................................................cpLlhtlLpFotlLlEpsh.sRplYuSh-....+LssLLsosshpllhusLpllhhhupR............p.h.tphhtpphp..hp+.l.pLApsa.............................................................................sspppshuLspts......................tph.tphs.slphpaYsps............................................................................................................................................ptp..ts..spshphhcl.p.ph.h..s.p.s.......tplhpphhp....lP............pppphtlhp+lRlApuhsstpp.....R.phlphRLhAlshLsh.t.....s.pp.hspll.ts.................lh...ppLs-..l.lphs...s...............................ph.hp...l..pshuLpsLsulsp..........cp...s+hss...............llsshus..s..s.HGhL.hllRpslpt........................................................................................................................................	0	71	121	188
+5841	PF06013	WXG100	DUF909; 	Proteins of 100 residues with WXG	Moxon SJ, Studholme DJ	anon	Pfam-B_7198 (release 9.0)	Family	ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. Homologues have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the Pfam:PF01580 domains in the YukA-like proteins [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.81	0.72	-3.98	120	3120	2012-10-01 21:44:22	2003-05-23 10:31:35	7	26	880	30	526	1700	48	84.80	18	66.58	CHANGED	plplsspplppsAsphpptssplpshlp.plpsph.stl.tu..sWp.GsuupuFpsthp.phptsh.pphhptLpplsppLppsuppapps-p	....................hphs.ttlp.st.u.sphps.t.upp.lcsh..hp.plpsph..psl..tu....sWp...Gt.u.sssap.s....t.h....s.p....hppsh.pplh...p.hLpplspplppsusshtpt-t...................	0	169	352	458
+5842	PF06014	DUF910		Bacterial protein of unknown function (DUF910)	Moxon SJ	anon	Pfam-B_7253 (release 9.0)	Family	This family consists of several short bacterial proteins of unknown function.	25.00	25.00	31.00	30.90	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.87	0.72	-4.05	26	915	2009-01-15 18:05:59	2003-05-23 10:36:21	6	1	911	3	89	305	0	61.60	50	83.25	CHANGED	MKTLYDVQQLLKpFGhhVYlGcRhaDIELMtlELccLYcusLlD+..csYhpAcllLp+E+phE	...M+ThYDVQQLLKpFGhllYhGcRlaDIELMplELpcLYcutLlD+..p-YLpAchlL++EHchE......	0	19	44	67
+5843	PF06015	Chordopox_A30L		Chordopoxvirus A30L protein	Moxon SJ	anon	Pfam-B_7254 (release 9.0)	Family	This family consists of several short Chordopoxvirus proteins which are homologous to the A30L protein of Vaccinia virus. The vaccinia virus A30L protein is required for the association of electron-dense, granular, proteinaceous material with the concave surfaces of crescent membranes, an early step in viral morphogenesis. A30L is known to interact with the G7L protein and it has been shown that the stability of each is dependent on its association with the other [1].	25.00	25.00	36.40	36.30	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.49	0.72	-4.37	10	57	2009-09-11 08:38:21	2003-05-23 10:41:39	7	1	46	0	0	32	0	72.70	57	98.13	CHANGED	-EDINEuNF.HLLosLSNssp...DsEFuATLSsl+ElIStINhKlLuINKKSKKNsRss-p...hsaVs+..REssRY	.hEDlNEANFsHLLhNLSNNKD..lDspauuTLSll+ELlStINhKIhsINKKSKKNo..+o.lEp....lpasuu..REhsRh..............	0	0	0	0
+5844	PF06016	Reovirus_L2		Reovirus core-spike protein lambda-2 (L2)	Moxon SJ	anon	Pfam-B_7350 (release 9.0)	Family	This family consists of several Reovirus core-spike protein lambda-2 (L2) sequences. The reovirus L2 genome segment encodes the core spike protein lambda-2, which mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1].	18.00	18.00	19.80	19.80	16.30	16.20	hmmbuild  -o /dev/null HMM SEED	1289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.02	0.70	-14.02	0.70	-7.60	4	56	2009-01-15 18:05:59	2003-05-23 11:11:48	6	2	22	3	0	58	0	1162.20	43	99.73	CHANGED	MAsVaGlpLsspLsosTsR+hhp.hpaDpLlosLpsssh.tp.aRuLc.psss.shoslQha.PLNuas.ssthltpshsacsWccaIp-+hpALss.LhRtYPlss.usRhlNPllhsAlsuuFLsspshsthLshLFls...cssIsslhssshohopch.sstcslhTPAGpKYlpLpuYsso.sssPshFuKclssYApsaYasshssp.phhapasuusslL.HFDpPT.G.HhLlPshuss.uhsohllstsshlLlESsL-phphNApAssuosVsRlDQsYHslhusp.sspsoLthRLssLSLLAlpGhQhss.lPspPThusVuuFluRLhu.Gcspphl..Rsc.lhlh.-SPhshsssst..YlphpssphshoIGshshlsDsspPltaLPQYc.ATs.shspupDuhpcssh.PLhspauhhhoGsAhhphhDhstcss.VassspLsphPssYFst-cthpRsLFSphRuhuDRShlKDsAslpahushlsPsssp.lLssuhSMAYlGASusHussDpPlIIcslhuGolPGVPhPpplpQFGYDVspGoIhDlshshPTGTFtFVYSDVDQVpDussDlsAosRtshuhLshshphTssGGshVVKlNFPTpshWpplFpphusphoolaLlKPhlsNslElFLl.FusR...ssuuLpsosulhhFLlshatR.psLscshsplP.hGs...lDDGsoshGlsslcl.sPshSshstshtlsshuhhsuhsssppShhsh.-SpGspssTIhu+RT.hSppRhsRLt.VPhlhssolshQpRhhssss.pLFsspusssTplh.Luhhhshhssussh.sls+hLDLGTGPEsRILSLlPsshsVThsDsRPsAps.usas.shTsalphDYLssuhhsustsDslTsIhSLGAAsAuAuhsLhsulpQLIphlssusspplaLQLNsPLsssuSl..sllEIDppsppYhFsshtRsEPYus.sAL.phlcslhPussloWhThSsohcWhcYslt.uoolo.sDIshAhphS+hsPIh+IDhsphPhch.PsshhVGtpsslplsuhsspsshpsphsuVplhossssNhsuhhuslul.assspscasLshsPspPGIhsh..llshsss.lshGShsIssPssolslsaP..upLDFT.uGsDsclssssaYcLulF..........lhhDGpaphsNP-+.t.hsoAussRVlpalhDluDsalLhYlCDVossslGchIthPLs-l.phsaPsNsslhhShPasuststlp.sGs.hssLss.shVLPsuhtlhshSTultsuhPTahVPsGsYshVhl	...........MAplhGlRLusoLSuPs.cphsppaThc-hhSsLchss...cPW+sL+sptss.slsAVpLhhPLpGhl.sh.hhthshsaspaEpahp.hLpsLt.plLRhYPIusYpschlNshlsNAlVuAFLSN.sahchLshLhls...cs..lpDlhssGhslppah..hctssl.ssAGpKa.lQ.hpsYs.s...ssDPsLFuKpLpsYuhsaYh.shpsh.pahhpH.SsussLlHaD+PoNG.HhLlso.oshs.Assh.lsAhsulLLESCLpQ.thNsps.supPVsR.spshh.h.us.a.ttpsoLpYpLhsLS.hhhNGYQhsc.hPtp.ssthluuhlupLhs.uts.Tsl.Pp.thhplhhDSP.shsGtst.salp+.tht.Ghplusl..hpssspsVtWhPQas.spu.ssD.u.s.lu+hTpLPLRscYushWsGsAL..asshsRppt.Vh..p.hsQhPssYFssD-pauRShFS.hRtltDRSLlKDTAsLhah.p.lsssps+chl.supohsYhGASusHus.sQP.lIcPhhpGplsGV..P.SV+QhGa-VspGsIsDlthPhsoGsa.FVYSDVDQV.sGcsDLshSSphhpS.Ls.hh+hThsGGShVlKhNFPTphVWpaI.ppl.P.hoShhLhKPhVoNNlELahl.Fu.+....puuhpsousVhhFhhsphtRYcsLps..pplPShG....lDDuhoVoslphlsl..suhSshpptttluh.ulhsslGst+hSlt.Y.-SatsplhsIh...oPtStphhsRLtYlPhl.Ppol-VQtRshhsusP.lFs..hsss.sp...LohhYshtloussa.-...schhLDLGTGPEA+.LphlPss.PVThsDhRPhs.PSGCWs.shTsFLphDYLssshlhustuDlVoClLSLGAAsAstshThctuhpQLlp.h.scusspslhlQlNCPhs.sstsl.+thLElspTNppYhF.phGR.EPa.shsuL.cIscshhPshslphhshs.sLpWhchAlhpssoloSssIhlA.hh.+ahPlhhhchcthshph.ssshhVGpsholsl.sapspssapshhssshhhohpsss.suh.stVos..ssspsphsLshs.ussGIho...llts.ss.lSLGShVl-uPDsslo.haP..ApLDholuGTDl-lplssaYclhh.F..........sh.DspapIhp.Dp.......us...sohshNhhhDhuDhahhhhlpDVpspslGhaI.+.L..Lso.shPsstchFLShP.-...hhVp.sGs..s.h.sutshs.PpsW.slssohsh.suhPoahVPPGc.YsLs.........	1	0	0	0
+5845	PF06017	Myosin_TH1	M_tail; Myosin_tail_2; 	Myosin tail	Yeats C	anon	Pfam-B_12631 (release 8.0)	Family	\N	31.10	31.10	31.10	31.10	30.90	31.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.14	0.71	-5.01	27	904	2009-09-13 17:10:37	2003-05-23 11:23:47	8	48	257	0	561	839	2	186.30	23	19.42	CHANGED	h+htAsclhpsKKccptpSl....RtFhGDYluhcp.psphpphhtspt........t........pllFust....VsKhsR....psKsppRtllLTspslYllt............sthphtlK++lslsplpulSlSshpDshhllHh......psptD.llpssaK.........oEhlohLpcphpp.tt..pLplp.husslphph+p........st.pshphthstssss...hhcsspsthhphsss	.......................................+..Asplhts.....+KpphttSl.....R.FhG...DYLshpp.....s.sp...htp..h.htppt.............................................plhFush.......VpKhsR............ptKsppRhllL.......TspslYll.............................sttphpl.Kp.pl.s.lss...........lpulS.l...Ss.hpDshhllHl...................................ppcsDhl..l.ps.s.ht............hEhlohL.hpt.hpp..tt.....plp.lp.hus.phphphpt.............tt.t..hphth.s.ts.....t...............htt.tp.........t.......................................................................	0	191	263	401
+5846	PF06018	CodY		CodY GAF-like domain	Moxon SJ, Bateman A	anon	Pfam-B_7573 (release 9.0)	Domain	This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. Presumably this domain is involved in GTP binding. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2].	29.50	29.50	29.90	29.60	28.60	29.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.92	0.71	-4.99	17	1124	2012-10-02 14:34:25	2003-05-23 11:26:54	9	5	1084	9	136	463	0	176.60	45	67.49	CHANGED	sLLpKTR+lNslLQ+u....sspslsFp-huppLu-VIcsNlallS++G+lLGYuhp...tphps-Rhcp.hhp-+pFP--YspsLhplt-TpuNlslssphosFPhEscp.FtsGlTTIVPIhGuGcRLGTLlLsR.scpFsDDDLlLuEYuuTVVGhEIL+t+s-ElEEEARp+AsVQMAIso	..........................pLLpKTR+lNslLQ+s.........htptlsapcluppLu-llcsNsaIlup+G+lLGYshp....ph.p..s.-Rlcp...hh.p...p...+...p...FP-.-.Yspt.lhplh-TcuNlslc..ss.ho.lF.PsE.s.+-hFs.s.u.l.TTIs.PIhGu.GcRLGTLllhRs..cccFsD-DLlLuEYuuTVVGhplLptpp-E..lEcEsRc+sAVpMAINo......	0	61	93	115
+5847	PF06019	Phage_30_8		Phage GP30.8 protein	Moxon SJ	anon	Pfam-B_7692 (release 9.0)	Family	This family consists of several GP30.8 proteins from the T4-like phages. The function of this family is unknown.	25.00	25.00	36.40	51.50	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.60	0.71	-4.42	2	31	2009-09-11 08:57:46	2003-05-23 11:33:00	6	1	30	0	0	23	0	112.20	68	99.49	CHANGED	MpTINLNATlKs+sasG....hhsEh.WhlhuVpGDll.spTs-G.usDFsapIplcNFFTG.IYcLNoslhGpI.....EppEhG......WY..sARpRAEpLIEKhKthGhlD.t+WphlK	.........MKTINLNAsVKTKCFNG....KYcETMWFLMAVEGDIIEVETTEGMGTDFTFTIQVHNFFTGWIYELNTVIVGKI.....EQNELGE.....WYYVTARQRAERLIEKMKKVGKLDMpHWKVVK..	0	0	0	0
+5848	PF06020	Roughex		Drosophila roughex protein	Moxon SJ	anon	Pfam-B_7712 (release 9.0)	Family	This family consists of several roughex (RUX) proteins specific to Drosophila species. Roughex can influence the intracellular distribution of cyclin A and is therefore defined as a distinct and specialised cell cycle  inhibitor for cyclin A-dependent kinase activity [1]. Rux is though to regulate the metaphase to anaphase transition during development [2].	25.00	25.00	25.10	30.20	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.03	0.70	-5.76	3	54	2009-01-15 18:05:59	2003-05-23 11:40:35	6	2	16	0	8	55	0	283.40	60	98.36	CHANGED	MNAPEEHKcTPLEVIHEFIKGVDDGTIRRDLGEDCILSYYSRNVRGAKAITGFLRTQLTpRYKHEsFEEAAplAKGDELLLQARFGRSFDuERRRIYEEKERsGTTsLHLHAESDDEEVNEEFSTTLITPPRPSSYNLNoLKYVEACGLLNRRDEHlYGGLDLGESCAVHLTLGYRSTaLPGGQVSGFEICLAVYDRGLTSLNRSTLlPPPhuISFuRRANARCNPTTDDEuDoEEDSPPPTuRRGVRRTLFTEENTQEEE..........DuDPDPIPEVE....QEQPAPQQAEETAREAVNIPVDLPTPsETTNsSSYTPRKRhQTTNGNEVPPKRTPGPQRMRF	...................................cTPLEVIHEFIpGVDDGoIRRDLuEDCILSaYSRNVRGAKAlTGFLRsQLThRYKH-sFEEAtplthGDELLLpARFGRSFDhtRRRIYEEKERsu.sT.....LHlH.sE.SDD...Eps...Nc....EFSoo......LITPPRPSSY.N.L..pSLKYVEuCGLLN+.Rs.EH.VYGGLDhG.EoCAVHLTLGYRpT.LPGGpVSGFEICLAVYDRGL.psLpRSTLss.P.huhS...hsRRup...hRCNsTTDDEuDsEED.PPPTuRRsVRRTLFTEENTQcEE..........................D.D.s.Pl.E.p............................QpQP..APQ..Q.s....ppsup...............s....VDlsTP.chTshsShTsRKR.Qt............................................................................	0	1	1	4
+5849	PF06021	Gly_acyl_tr_N	Glycine_acyl_tr;	Aralkyl acyl-CoA:amino acid N-acyltransferase	Moxon SJ	anon	Pfam-B_7828 (release 9.0)	Family	This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.	25.00	25.00	32.30	25.90	22.50	23.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.39	0.71	-4.91	10	198	2009-01-15 18:05:59	2003-05-23 11:49:27	6	4	36	0	101	166	0	181.00	41	67.51	CHANGED	Ml.hLQuuQhLQMLEKSLRKSLPESLKVYGTVFHINcGNPFNLKALVDKWPDFpTVVlRPQEQEMTDDLDHYTNTYplYSKDPcpCQEFLuosEVINWKQHLQIQSSQSuLsEsIpsLAAoKSsKVK+opsILYhssETtK+LsPSLh-sKp.LssssG+P+...ulcQchFKLSoLDVoHAuLVN+aWpFGGNERSpRFIERCIpsFPo	................................Mh.LpssphL.hLcp.LcpplPE..SL.K.VYGsl.hplN+GN..PFph-llVDpWPDFpsVlsRPQ.cp-MsDDhDaYTNsYplaoKD.pphpchLtps-VINWcQthQI.Q..u...Qp.sL..s.-sl.pplA..ss.Kplp..V.chp.pt..hLhhh.phh.p......t..s.s..s.........csp........t.tp..p........t.ppt.h.+.ho.LsloaAsLVNchWphGGNE+ShRaIpchIpsFPo......................................	0	4	8	26
+5850	PF06022	Cir_Bir_Yir		Plasmodium variant antigen protein Cir/Yir/Bir	Moxon SJ	anon	Pfam-B_8754 (release 9.0)	Family	This family consists of several Cir, Yir and Bir proteins from the Plasmodium species P.chabaudi, P.yoelii and P.berghei.	20.40	20.40	20.50	20.50	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.06	0.70	-5.17	119	1443	2012-10-01 19:45:41	2003-05-23 12:01:26	6	3	6	0	1275	1447	0	235.70	29	83.60	CHANGED	M..scp....h..C......ppFptlpphhsDc.Lspssp...YpFpspt..hppYC.ss.s.............Cs..................sD..l-KIsAGsLaLhsp.hats.s.hp..p.s+sphs.lltYIhIWLSYhLsh.csppphs..slp-FYspaIpsssc.Ypp..............pIsss.psYs..sYK-lI-++ptlhs..hshpplSKFY-AFKhLCsMYsph.....st.psssCsphhppAscFVcKYcc.LNp.......sss..scsosYspl...LSoLSsDYsNhKpcCss.....ptph..ssLPshcp.......................................................p.ssSSSSIssKL....lslL.IFs.AIulFLGIu...YK	.....................................C....t.h..l.p.hssp...t.ptp...hph.p.t......hptY.Css..t................pC.p...................ss..hc+l.suuhlaLhpt.hhtp..t...t.............tpt..p..hh.Yhh.lWLu...YhL.s.pp.p..p..t..h.s.....slppFYspaIps...s...p...p...Ypp................lpts......pt...hp......s..ac.-.lI-c+pph.hs..hs..h....p...lScaY-sFK.LCphYsph.....s.t...pss...p.spp......h..p..p...Ap..c.Fs....cc.Ycc.....L.pp.......s......s.....sc....s....s.....sY.ppl...LssLSsDYssh.....Kp.ppss...........h....sslsp..h.pt...............................................................................hspsssh.h..spL....h.lh.Ihs.uhshhlGl.YK.................................................................................................................................................................................................................................................	1	0	903	1275
+5851	PF06023	DUF911		Archaeal protein of unknown function (DUF911)	Moxon SJ	anon	Pfam-B_8782 (release 9.0)	Family	This family consists of several archaeal proteins of unknown function.	20.20	20.20	20.50	20.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.06	0.70	-5.20	8	70	2012-10-11 20:44:44	2003-05-23 12:12:43	7	2	49	0	43	95	1	261.40	34	98.55	CHANGED	Mhhphp.h..+hL.+Rl+th.tscsVsEELRGWpWspPPVpPpsh.ltLolSDls.sYCsTtRDVYL+hVLshRGc.sstlhhGpsIHcsatpulc-l+phhhuucs.s.sh.p.hhtpth....h..phhc....huctlacalsphhpuchscl+...ut.sttsc.Sluhhs..lPhhsEasVDGSsLGLSshlpVDA..hhLs..lVlEhKsGpapcpHcLALAGYALAlESthElPVDaGhLlhl.shNssl.+hpsclhhIu-sLRpEFLEtRDcsh-lltsssDPGluhcCsssCPFhchCp....t	............................................................................................h..+.L.+chh.sh.ttsslsEELRGWsappPPlpPhth.htLulS-lu.tYCsTtRDlYLR.+.Vhthpsc....s.t.shhhGphlHclhtp.shp...php+hl.t.s....h............t..h...............h....h..t....th..............hspph.p.................hsctlhchh..sh..plhuc.hpc.hh.......st....h...........Shs....s......lP..l.h......sEht....VD.Go.LGLS.t..L.ps.......DA.h.h.hs........ll.lEh....K.h..Gp.....h..p...c..h.HcLuLAGYALAlEuthElPlDhGhllYl.sh.s...tsh...chphcshhIussLRpcFl-tRDchh-hltpttD.PG.hs......p...Cs.tsCPFhphCpt...............................................	1	19	29	35
+5852	PF06024	DUF912		Nucleopolyhedrovirus protein of unknown function (DUF912)	Moxon SJ	anon	Pfam-B_8809 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus proteins of unknown function.	26.00	26.00	26.60	26.00	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.59	0.72	-3.96	24	60	2009-01-15 18:05:59	2003-05-23 12:15:59	7	2	52	0	9	56	1	102.10	28	58.08	CHANGED	LDVPY-RLGspp.+V-YIPLKLALsD...............sssssssststss..s..spsshsptsss..........pphshhpllllulluhlslhlLL...YsIYYFVILR-...+pp.......ss....t.pPsal	............................................LDlPY-RLuspp.pV-YIPLKLAlsD...............stsspssspppsss.s..hs.pss.hsstsss..........tspts.hhsllllulluhhslhllL...Ys...IY...YFVILR-+pppts............................	0	8	8	9
+5853	PF06025	DUF913		Domain of Unknown Function (DUF913)	Yeats C, Sammut SJ	anon	Pfam-B_6534 (release 8.0)	Family	Members of this family are found in various ubiquitin protein ligases.	24.70	24.70	26.30	25.10	18.90	23.60	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.09	0.70	-5.71	11	332	2009-01-15 18:05:59	2003-05-23 12:19:24	7	42	240	0	227	319	4	324.60	25	10.30	CHANGED	hSRslchLDshlcuspsAhuhh.osu+GhDslsshIcaEsppshc...........ssptuuuh.spppssshs.......ap...IsYhppphL+hhh+Fls+hhp......uuGhscsLRNLlD..spLlsSL+hlhcpAclFGupVaSsAssllSsFIHNEPTSaullsEAGLocuFL-Als.............................................................ssIhsusEAlosIPsAhuAICLNuSGLcLFpo.p.sAlcsaFcIFpSPpHlKsLpcs.......-hssuLGoshDELlRHpPuLKsslhsulIchlscluhLs+shshspshuu+h.......................................thhssshststthsts.hhp.hsso.sspspsss......................s..thshs-hlhsVuRFLtuhhpNpusCp.FIcpsGlEhlLslhsLssLPhDF	..................................................hshphl-hhht........hshh..s.tpGhshh..hlphElphshp..............................................................p.s..ts..s.p.hp..h..................hp.......h..pptthlKshLph.lp+hhp..................ssshsctlRp....lhD..usL.puL+pIlpN.sc.haGssla.hAsslloshlapEP.o.huslp-sGLs..psh.Lculh...................................................................................................................psl....sop-slsslPsshuAlCLNspGLp.hhp..p..pshc.phh.clhhSspal.s...hppp........................-hssslGsuhDELhRHpPsL+sshhssl.lphlpclsthsps..t..t....h.s.......................................................................................................................................t..................................................................................................................................h...l..hhp.l.s......p...s....t...thp.t.Fl.t.ttGl..llp.hhth.ths........................................................................................	0	72	122	187
+5854	PF06026	Rib_5-P_isom_A		Ribose 5-phosphate isomerase A (phosphoriboisomerase A)	Moxon SJ	anon	Pfam-B_5144 (release 9.0)	Family	This family consists of several ribose 5-phosphate isomerase A or phosphoriboisomerase A (EC:5.3.1.6) from bacteria, eukaryotes and archaea. 	26.00	26.00	26.20	28.80	25.70	25.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.95	0.71	-4.95	58	3557	2012-10-04 00:26:15	2003-05-23 13:17:25	9	10	3267	42	923	2338	895	171.00	42	74.26	CHANGED	lsuVsTSppopthspphGI..sltslsph...splDlslDGADElD.sp.hshIKGGGuALhREKIVAssuccFllllDpoKhVp.pLG..pa..PLPVEVlPhuhphlh+plpp....hGs..ps..plRhs.t......tshlTDNGNaIlDspht...I.pD..PttlpcplpplsGVVEsGLFssh.A-hlllGspcGsp	......................uVsoSptospphcpl.GI.....l.h...s..l.s-V........s.p...lDlhlDGAD....El....s......sp......hphI....KG.....G......G......u..A......LhRE.KIVAssuc+.aI.sIs.DpS.K.h..Vc..hLG...pF.............PLPVEVlPhutstVtRpltc........................hGs..pP...phR.s.t...........................hlTDNGNhIlDlphh.......pI........c...................Phtlpptls.tlsGVV-sGLFssh..A-..h..lllGst-Gs....................................	0	249	520	743
+5855	PF06027	DUF914		Eukaryotic protein of unknown function (DUF914)	Moxon SJ	anon	Pfam-B_7017 (release 9.0)	Family	This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.09	0.70	-5.60	5	558	2012-10-02 19:55:49	2003-05-23 13:27:53	7	12	225	0	378	1427	836	252.40	26	71.49	CHANGED	pclpch.hTK+hLIuluLGQlLSLLlTusAhTSuYLAc+.tlNsPshQTFLsYsLLsLVYTshhlaRpGscphh.hIKRKWWKYhLLALlDVEANYLVVKAYQYTolTSlpLLDCWAIPsVllLSWhFLKsRYRlh+IlGVVlCIlGVVhlVsSDVlAGcRu..uGSNPllGDhLVLuGATLYAVSNVsEEalVKsLspsEllGhlGLFGAIISuIQluIFE++-LtuIHWos-huLLalGFALsMFLLYSLhPILIKsoSAThaNLSLLTSDhWSLlIGlFlFHYKVsWLYhLAFsTIhlGLIlYSspppcpsEsscsplpshpccG.ss-sscTsc	.......................................................................................................h............................................................................................................................................................................................................................................................h.....h.h.a....h...h.h....u.h...h.D..l..p.u.N.a..h....h.s..h.Ah..p....Y....T.o.l..s.S.....h.p.LLsshs.Is.....h.s.h.l..l..S.hhhL...t.h...Ra.phhphlG.lhls.l.h.G...lsh.l....s......h..u..D.......h........h......s............s.........p............p.......t..................s.....u...........s............s...............l.....h...GD.....l.l...s...lhu.A.s......l.....Yu...l.ssV..h........c.E....h...h......V........p...p.....h...s...h.....h...c...h....l..u..........h...h.....G...l..F..G...h......l......l....s....u.....h....t...h.......h.......h........h......c.....h......t......t.......h......t..h.............h.....s................t.......h......h................h...h...h..h......s.....a...s..h....s..h....h....h.h...a......h.h..s...h...h........h.....h..h...s.s.u..s.......h..s....l..u..l....L.....o.....s..sh...a....ul.......hht.h.hh...a.t...............h.p.h...h.a....l.u..h....hhh..h...hG....hh..h.......................................h.....................................................................................................................................	1	129	205	295
+5856	PF06028	DUF915		Alpha/beta hydrolase of unknown function (DUF915)	Moxon SJ, Bateman A	anon	Pfam-B_7094 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.57	0.70	-5.29	13	1150	2012-10-03 11:45:05	2003-05-23 13:34:06	6	5	577	4	145	1113	409	233.40	31	85.76	CHANGED	psp.psstpphhPTIaIHG.uGospShstMlsplhscts.sspcsLs..hsVsp-GplphpGplsKcsppPhIclsFccNcs..uohccpupWlcplhscLpppYphpphNhVGHS.GGhuhshYhhcYusccshPplpKhVsIuusFNslps.sts.shh.hhppt.spspTshaptlhpp.ppplssslcVLsluGshpssppoDGhVshsSShoh+alhtpsucsYpcphhsGcpAsHSpLHENspVschltpFLapp	............................................................t......h.pp.hP.T.lalHGau.....uo.t...........pu.ptMlpphp.cps..s......s..........ppllp...........spV..spsGpl.p..h.p..Gp..........l.s..ps.s..ppPll.pl.t..Fcs.N+p...........sshppp........ut........a.....hppslpt.L..p.p............p.....Y.p...h...p..p..hNhV..GHShGsl...sh..s.hYh.............hp..a....s....p.........c......p...s..l....P........plp.KhVsI.....u.....u.sa...Ns...h.....................s..........s.t..........................p...................................................t.t.u....P.....s.....p...h...s......ph...........apph..hth.......c...p.hhs.p.slpVLs..IhG......s..................p..........s..........s....pSD.GtVs.sSutul+Ylltsp.sp.sYpEhph..p...G..p..s..ApHSpLH.-.N.t.pVs.phlhpFLat...................................................................................................................	0	31	73	109
+5857	PF06029	AlkA_N		AlkA N-terminal domain	Yeats C	anon	Pfam-B_13157 (release 8.0)	Domain	\N	26.00	26.00	26.10	26.30	25.50	25.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.48	0.71	-4.03	90	1096	2012-10-02 11:58:57	2003-05-23 13:41:40	6	11	1039	41	244	792	63	115.30	42	29.96	CHANGED	slpL..sYRPPacWsthLsFhutRAlsGlEtl...........................ss..s...........YtRolplss......s.....p......................G.hlplphs.........stp......ptlplpl....sh...sthpsLt.slluRlRRlaDLDADPtsIsstL..pshhsshlstpPGLRlPGuaD	.......h.hpL..sapPPaDWshhLuFLAuRAVsGVEpV...........................s-s.......h.......Y....tRols..lsp...........t........p.................................Gllssps.s....................................t.p...........cs..Lclslss............shhsshs....pslA+.h.pRLFDLcssPptlsusL..........us.Lsss..cPGLRlPGshD.......................	0	58	130	199
+5858	PF06030	DUF916		Bacterial protein of unknown function (DUF916)	Moxon SJ	anon	Pfam-B_7106 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.00	21.00	21.00	21.00	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.63	0.71	-4.32	23	922	2012-10-03 16:25:20	2003-05-23 13:51:56	7	3	256	0	77	620	6	120.50	33	35.26	CHANGED	FuVpsllPcNQssps..oYFDLphcPspppsLplclpN.soccplplclssssAhTNssGhlsYspss.sphD..poLcashschlchscp.....lslsspps+plslslpMPscsacGllhGGlahp-c	........................FsVpshlP.-N.Ql..ccp..poYFDLthpPsp..pQp..lplplpN.poc.cclslpls..lssAs.T.NsNGll-Yspsp..tchD.....poLp......hsls-llph..scp........l.plsscpppslshp.lphPp....c.sF.sGlllGGlhhpp......................	0	27	62	67
+5859	PF06031	SERTA		SERTA motif	Bateman A	anon	Pfam-B_7533 (Release 9.0)	Motif	This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins [1]. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif [2].	25.00	25.00	30.30	29.20	24.10	23.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.63	0.72	-4.66	15	271	2009-01-15 18:05:59	2003-05-23 13:59:28	8	2	72	0	175	259	0	37.50	46	11.67	CHANGED	lLslSLcKLpphcs.sEssLRRSVLIsNTLRRlQsElc	...lLslSLhKLp.phct...sEPsLpRSVLIsNTLR+IppEh.....	0	23	39	93
+5860	PF06032	DUF917		Protein of unknown function (DUF917)	Moxon SJ	anon	Pfam-B_7195 (release 9.0)	Family	This family consists of hypothetical bacterial and archaeal proteins of unknown function.	26.20	26.20	26.50	29.80	25.60	26.10	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.88	0.70	-5.90	51	579	2009-01-15 18:05:59	2003-05-23 13:59:58	7	16	394	2	281	514	91	333.10	33	69.65	CHANGED	l..otpDl-sluhGuulLGoGGGGsPahGphhstptlpps....tplcllsh.--l....sD-shllssuhhG..uP.s.......lshE+......ls.sGs.EhhpAlctlpc.hhGpc.lsulhshEhGGsNulhshh..sAuthGlPllDuDuMGRAaPphpMsThtlt.Ghss.....sP.hsls-tcG.............sssll.ss........hss..hhsEclsRshss..phGutsshuthPhsuppl+ctu.lhsTlShuhcIG+Alppuctppt..shlpsllchh...sG.......phLF.pGKls-lc...Rc.spsGFshGpsplpGhpt................pspphpl.FQNEhLlAtps.............spslsssPDLIslLDt-supPlsopp...........l+YGh+VtVlulPssshhpotp.Gl-hsG....PpsFG..h.shsatPlp	.............................lstpsl-sluhGuulLGoGGGG..sPahuthhshptl.cps.....tslcl....lss.--l......s--shhhs......suhhG..A..P..s.............VhhE+........hs..pGs..Ehhcshctltc...h.........h...s...........pc.hsuhhshEh............GGsNuhhslh..sAA..ph......G...lP..llDuDsMG.RAaPph......pMsThtlt..Ghss.........sP.hslsDtpG....................shslh....p.s.............hss...ths.EplsRshss........phG..........u.t.shhuhhPhsGppl.........+phu..lhsslohuhclG+sltt.sptppt.....phhpsllchs...sG..............hhLF.pG.K....lh.-Vp........Rc.s......psG.FshGpshlpuhst...............................tspphtl.FpNEpLhAtcs........................spslAhsPDLIshlDhco.....upslsopp.............................l.+YGh+.VtVlulsssshWpotc.GlchsG....PphFG...h..chca.sl................................	0	113	191	243
+5861	PF06033	DUF918		Nucleopolyhedrovirus protein of unknown function (DUF918)	Moxon SJ	anon	Pfam-B_7213 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus proteins with no known function.	25.00	25.00	179.60	179.50	19.30	17.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.68	18	39	2009-01-15 18:05:59	2003-05-23 14:01:47	6	1	36	0	0	38	0	152.40	46	91.30	CHANGED	LEFDslslDLRHVsF..stsuts-.......tEYIlFLNVKRAhYpNFplssDhSLETLAlalYpssphslsG.sphs+sssas-h....lsaNpsD+spSllI-Lss-..ARlVVAKplpssEpYHQRlSGalDFE+R....Hpps....shlc.ssstRstLDREhEIKLhp	LEFDslslDLRHVpF..stsst..ss.......pEYIIFLNVK+AhYpNFplssDhSLEoLAhalYcpsphslsG.sphp+ssshs-h....lsaNcpD+NpSllI-Lsp-..ARllVAKplpssEpYHQRVSGalDFEpRHsps.........hlc.ssppRstlDREhEIKLhp.	0	0	0	0
+5862	PF06034	DUF919		Nucleopolyhedrovirus protein of unknown function (DUF919)	Moxon SJ	anon	Pfam-B_7250 (release 9.0)	Family	This family consists of several short Nucleopolyhedrovirus proteins of unknown function.	21.00	21.00	21.80	21.00	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.95	0.72	-4.35	19	53	2009-01-15 18:05:59	2003-05-23 14:04:59	6	1	52	0	0	48	3	60.20	35	44.30	CHANGED	spspsLppQLscIsptK+plsIc.pHaE+l++lTKsspElpcl-p+lhchR.cFLsaGlppF	......p.pppsLcpQLscIsptK+p.lslp.pHaE+l++ITKsspElppl-p+LhchR.pFLpausppF..............	0	0	0	0
+5863	PF06035	Peptidase_C93	DUF920; BTLCP;	Bacterial transglutaminase-like cysteine proteinase BTLCP	Moxon SJ, Sammut SJ, Eberhardt R	anon	Pfam-B_7277 (release 9.0)	Family	Members of this family are predicted to be bacterial transglutaminase-like cysteine proteinases. They contain a conserved Cys-His-Asp catalytic triad. Their structure is predicted to be similar to that of Salmonella typhimurium N-hydroxyarylamine O-acetyltransferase Swiss:Q00267, in Pfam:PF00797, however they lack the sub-domain which is important for arylamine recognition [1].	20.50	20.50	21.00	21.50	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.25	0.71	-4.84	28	779	2012-10-10 12:56:15	2003-05-23 14:06:43	6	1	470	5	245	627	58	155.80	33	71.69	CHANGED	MssGuhTStPlGHYEFCpcpPsECssss.....tsssslpLTsphWpplhcVNtsVNpsIpPhTDh-laG.hcEhWuYP..sstGDCEDYsLhKR+hLhc.sGhPsusLLlTVVRpssG-GHAVLTVRTD+GDFlLDNLsscVhsWs-TsYpaLKRQSpscsGcWVslpcscss.hVuS	.......................................................................................................s...t.t....h....p...pLtpVNphhNpplp.hs.DhclaG.....pcDYWuhP....h....s.......s....sG....DCEDaslhKhhpLhp.hGlssspLhl..o.h....V+.....s.............p.....s.......p.......u.HhV.Ls..h...t..T..s..p..u..-.......hl.LDNlssplhshs.p...................................tt............................................	0	47	124	172
+5865	PF06037	DUF922		Bacterial protein of unknown function (DUF922)	Moxon SJ	anon	Pfam-B_7397 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.40	20.40	20.40	21.40	20.20	20.30	hmmbuild  --amino -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.14	0.71	-4.91	18	220	2009-09-11 05:34:11	2003-05-23 14:39:37	6	3	125	0	60	151	15	158.70	36	77.91	CHANGED	aYuIsGpTus-L.csLuppGPhht.pupRa.GtTphchshc.hsYtpp.sGtCslssscspLplphpLP+hp..ppsss-lphhW-shhuslc+HEcsHucIA+shs+clEpslhuL..tscssCpplcthlsphssclhpcacppppcFD+lEtsstsphpthlL	................................hYsIsGpTss-L.culuppGPhlt......tp..+h.utTphphshc.hcascp.sssCpVtsspspl+hphoLP+hp..pphuPtlthhW..DshhssI+RHEcsHschA+shsp-lERphhuL...scscCpplRtslsKhhschhpspcpppppFD+VEhsNhsNh.phlL.................................	0	9	28	39
+5867	PF06039	Mqo		Malate:quinone oxidoreductase (Mqo)	Moxon SJ	anon	Pfam-B_7465 (release 9.0)	Family	This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidises L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators [1].  	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.68	0.70	-6.32	17	1946	2012-10-10 17:06:42	2003-05-23 14:49:47	10	3	1474	0	309	1213	419	469.70	48	94.87	CHANGED	ppspsDVlLIGuGIMSATLGshL+ELcPsWpIplhERL-ssutESSNsWNNAGTGHSALCELNYTsEtsDGoIDIsKAlcINEpFplS+QFWuaLVcpGhlpsPcsFINslPHhSFVhG--NVsaL+KRapALpppsLFcsMcaS-D.-plpcWhPLMM-GRsssp.lAAThhstGTDVNFGtlT+pLhppLppp.shplpas+-VpDl+Rss-GsWpVslpshpsuppp.slpu+FVFIGAGGuALsLLQpSGI.EuKsauGFPVuGpFLtssNP-llcpHpAKVYGKAsVGuPPMSVPHLDTRhl-GK+sLLFGPFAsFSsKFLKpGShhDLhpSl+ssNlhsMLusGhcphsLsKYLlsQlhhSp-cRhssLRcahPpA+s-DWcLhsAGQRVQlIKcstcpG.GhLpFGTElVsucDGolAALLGASPGASTAsslML-lLc+sFs-+hp..pWpsKlK-hlPSYGhcLsscspLhcclpt.oucsLpL	......................................................pppcsDVlLIGuGIMSATLGohL+ELpPpWsIplhERL-ssAt.ESSNsWNNAGTGHuALsELNY...T..s.p.ps.DGo...l.-IpKAlpINEpFplS+QFWuahVcpGhlp.sP.csFIpsl.PHMSFVhG-cNVpFL+pRapALppp.sLFcsMca..o-..Dh..p..pl+cWhP..Lh...M...cG....R....c....s....s....p........l.A.A.T.th.-.tG...TDVNFGtlTRpLhp....p.L.....p.....p.....c......s..sp..lp..h..spEVpslc....+.....p.....s.....-.s.....p......WpVpl..p.s....h......p.s..G....p.t..p...phcu+FVFIGAGGu.AL.LLQKoGIPEuKchuGFP..VuGpFLhsp.N.P-llpp.HpAKVYGKAslGAPPMSVPHLDT.R.h.....l.D.GK+sLLFGPFAs..Fo...sK.....F.....LK...s......G...S...h..h...DL..hp..S..l+...s.....s....N....l.....h.....s.Ml......s......s.G..lc...NhsL....s.KYLlsQl.....h.....h..o.....c......-c.....R...h..psL+caaPp.A+.sED..W.c..Lh..p..A.G.QRVQlIKcst.cp...G....GsLpFGTEVVsupD.G.olAALLGASPGASTA.s.slMLclLc+..s..Fs-chp..pWps+l.KphlPSYG.h.p.Lsp.c.th.hcchhp.TscsLtL...........................................................................................................................................	0	65	172	257
+5868	PF06040	Adeno_E3	Adenovirus_E3; 	Adenovirus E3 protein	Moxon SJ	anon	Pfam-B_7475 (release 9.0)	Family	This family consists of several Adenovirus E3 proteins. The E3 protein does not seem to be essential for virus replication in cultured cells suggesting that the protein may function in virus-host interactions [1]. 	25.00	25.00	29.90	27.40	24.20	20.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.92	0.71	-4.18	4	61	2009-01-15 18:05:59	2003-05-23 14:54:17	6	1	40	0	0	51	0	125.00	48	70.68	CHANGED	IKsEhphoau.....L.LhQPhL.sh.Qhhpt..p+TF.ll.soosSshP......LP.TNp.pophppRapRsLhpoNTTh.+TGGELRG.PTs....sPW.VsGLlsLGlVAGGL.LlLCYLYhPChoYLVVLCCWFKKWG..	...............h.......phs.....LsLapPhl.GTYpC.pGPCpHTFsLVssTssSThs.......PETsp..tph.......l..s.oNTs..+TGGEL+s.P.T-t..hsPaEVVGallLGVVhGGhlhlLs.hYLPCas.lhlhhCWh++hG..........	0	0	0	0
+5869	PF06041	DUF924		Bacterial protein of unknown function (DUF924)	Moxon SJ	anon	Pfam-B_7600 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.80	20.80	20.90	21.10	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.34	0.71	-4.55	154	813	2009-01-15 18:05:59	2003-05-23 15:02:49	6	15	724	2	309	757	800	176.50	40	82.71	CHANGED	lLcFWF.............ptstsp......p.W.FtpssshDppl+pRFts...hhp.tAspGc...Ls.......pWtss.s............pGtLAhlILLDQFsRNlaR...soscAFAs.DshALslAppAlspGhD..p..plss.......pRhFhYhPhhHSE...sls.QcpulpLapph.....ss....................tp..............................slcaApcH+clIcRFGRFPHRNslLGRpSTs-EhtFLpp.sGt	................................................................lLcFWF........................pttt.p.......t...W.F.......s......p.......s.....s......s...hDtpl+p+F..tshhp.tAtpuc.....Lt................................pW..pps..s.............pGtLAhlIlLDQFsRNhaR.......so..sc..AFA..s....DshALslApp.A.l.sp.G..h.D..p....pLsst.....................pRhFhYhP..ahHS...E...shs..Qcpu...lpLappl.......s.s.....................................t.t.......................................s.hcaAhcH+sIIcRFGRaPHRNslLGRtSTsEEhtFLppsG...................................	0	92	175	252
+5870	PF06042	DUF925		Bacterial protein of unknown function (DUF925)	Moxon SJ	anon	Pfam-B_7663 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function. This family was recently identified as belonging to the nucleotidyltransferase superfamily [1].	25.00	25.00	25.60	25.40	23.10	23.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.08	0.71	-4.67	40	786	2012-10-02 22:47:23	2003-05-23 15:05:00	6	3	739	1	139	566	26	158.90	40	86.99	CHANGED	L..ctscp....LsL.P-hhLuAGhlRshVWstLcshss..ssls.....DlDllYFDst...-hohct-tplpppLp.phhP...thsW....-V+NQARMHlhpss........sPYpSopDAlupasEpsTAlGlcls.............tssplclhAPaGL--lashplpPN.st....c.phslappRl.tKpWpppWPpLplht	..............LphhcpLtL.schalAAGhVRNhlWshLpspss.hss.s.....DlDVIaFDs....cho.cpphtlE.p+L.ppphP..................phpW..plKNQuhMHh+ssc........sPYsSopDAhS+aPEpsTAlGlRLs..............................cc.sphELhAPaGL-DlhshpV+Ps.P+....ctchplYppRltpKsWpp+WPpLph..t..................	0	33	66	101
+5871	PF06043	Reo_P9		Reovirus P9-like family	Finn RD	anon	Pfam-B_8265 (release 9.0)	Family	\N	25.00	25.00	219.50	219.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.86	0.70	-5.37	4	51	2009-01-15 18:05:59	2003-05-27 10:08:25	6	1	7	2	0	34	0	262.00	57	99.91	CHANGED	MAD.pRRsFGuYpIpEIThppsQsshNssp....QssSsTpsphusp+hPlLDDGIacLlshLlcGssF-copYsGF-YSHLPsLERsFNTASsYVscpaplhhEphsLctY-hppsISlpuP-FolsLEa.hKscspuppp..EN-...shcslss+lls...........LlslhsR-pE-.hsppl.EGEsAllslhKMalpGFLhaLGcN.ssYD+QLsIEKYRPLLluIlGYEahhuhcs.pKclN+laYpLATFsNYPFslLRapLpSllssPs.IcpcItK-GLFK.IsosshhG.sppoV..hhRGIssSpSFLN.K+YRphRoRhsuNVcplIpsDhSplchss	.......sFGuYpIpElhhppsQsNhNsNo....pNopsTpsphuhp+hPlhsDGlatLhs.LLcGssF-KohYpGaDYSHLPNLEpsFNTASsYVstpYcIshsEhpLcsYshscohSVh.P-FohsLEa.lKscppoDpss..cENE............phKPpT++IVs.............pLlsLhNR-p.E.hsEpl.cGEhAlIslFKLYIpGFLhHLs.N.s..........................................................................................................................................	0	0	0	0
+5872	PF06044	DRP		Dam-replacing family	Finn RD	anon	Pfam-B_8314 (release 9.0)	Family	Dam-replacing protein (DRP) is an restriction endonuclease that is flanked by pseudo-transposable small repeat elements.  The replacement of Dam-methylase by DRP allows phase variation through slippage-like mechanisms in several pathogenic isolates of Neisseria meningitidis [1].	22.70	22.70	23.10	26.80	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.84	0.70	-5.39	6	296	2012-10-11 20:44:44	2003-05-27 10:14:51	7	5	224	2	16	88	13	170.80	60	96.61	CHANGED	MsLaFNppLuKsYKSpSQIlRVLSEsWVt+puYCPNCGsp.lspFsNNpPVADFYCspCpE-YELKSKK...uplushIsDGAYpTMIERIpSDsNPNFFFLTY.sc-acVsNFllIPKHFFTP-hII+RKPLussARRAGWIGCNIsLsplPEuGKIFLVKDpQlh-s-pVhcpapKsLFLRppsh.pSRGWhL-IhpCIDKls.spFoLsplYpFEscL+h+aPpNNaIKDKIRQQLQlLRDKGhIEFlGRG+YRKl	......................................................................MpLaFshpLscp.ppsop+hRlhoEsWl.+puYCPsCGspPhp+F....tNN+PVADhaCspCpEpaELKSKp.......tshu..s..sls..DGAYtTMhcRlpuDsNPNFFF...............................................................psuplhp.p.VhcpappsLFLRppsh..pp+GWhltlhpCID.pl..ppFoLppMYcF.E.scLp..FspNNHIK-KIRQQLQILRDpphIEFhG.RGhY+K..........	0	7	14	15
+5873	PF06045	Rhamnogal_lyase		Rhamnogalacturonate lyase family	Finn RD	anon	Pfam-B_8355 (release 9.0)	Family	Rhamnogalacturonate lyase (EC:4.2.2.-) degrades the rhamnogalacturonan  I (RG-I) backbone of pectin [1].  This family contains mainly members from plants, but also contains the plant pathogen Erwinia chrysanthemi.	19.90	19.90	20.10	20.00	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.30	0.70	-5.04	13	168	2012-10-02 23:57:29	2003-05-27 10:28:12	6	17	36	0	104	163	0	162.80	35	28.74	CHANGED	M...................................................p.p......VllDNGllpVTlSsPsGhlTGl+.YsGl.cNlLch..scppsRG.............YWDlVWs.sGpps.....hh-h..................lcGocFcVIsps-EQlElSFsRTas.S.csssl.....PLNlDKR...aIMh+GsSGhYoYuIhE+lpsWPulslsphRlsFKLspcK.........................................FcYMAluDsRQRhMPhssDRsssRG..psLAYpEAVhLlcPp-spa+...GEV	.........................h.............t.............lhlcNGllplohopPtGhloulp..YsGh...pNllc......spt.....pspG.................YaDhsWp....uttt..........hth..................................................................................................hpssphpll.p....spp.lElSFhp.a..s.p.sp.h..............slsl-h..+........hlhhcusSGhYsYuIh-+.tthP.shsl.sphRlsFKLppcp.........................................FpYMAluDspQR.MP.sp.DR...ps..t.LuY.EAVhLspP.psph+...GpV..............................................	0	12	62	85
+5874	PF06046	Sec6		Exocyst complex component Sec6	Finn RD	anon	Pfam-B_8361 (release 9.0)	Family	Sec6 is a component of the multiprotein exocyst complex.  Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localise to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner [1].	30.10	30.10	30.50	30.50	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.79	0.70	-6.43	38	580	2012-10-03 17:31:52	2003-05-27 10:42:54	8	14	271	2	371	521	5	457.30	20	72.59	CHANGED	FpplstlhctFcctlhtlhtshlphscps.sshlVcll+Il-tEEppDpchtthpphtt......................................................tpsRsa+c+hhcslcpulpppap.....pstpthssctth.thL-plt.alhs-LhhVpptlsshaPs.caplhchahp.hYHptlpshLt................pl....sss-hsutcllslLsW.scpYts..hhsphthh..................tsplpPllsssth.ppLhccYhphltpplp-WhsplhcsEpppahp....spsP-.....................ct-G.............hatspsshphaphlppQlplA...usohpscllthslcphsphlpphppshhphlc-chcp..............................................sshh-aLlAhsNsphtst-..........hhsshppcatshls.....p.ht.thsslhsshsclsspshptllchlat.D..Lpshhscla..o....ppWhss.........pshcplssTlp-Yh.sDhpp.lp.sh.hphhhpphhcpllhpYlptlhp.......+phthp.spctpphsc+lppDspthhphFpphh........thhhsphphlphlhthl.....hps.s.l........................hh.hpslhspY.Dhshs......alpulLpsRsDhs+uphppllpphpphhtshp............slhscl	.............................................................................................................tht.h.p.htptl..hh.p.h.hst....tt...thlhphhhllp...E-t..ctth.t.t..............................................................................s+ta+phhhphlp..tshptpht.................t....t.....t..........h..............Lp.ht.hhhp-L.h.stphh....hhP..capl............hphhhp.hYHpthtphlt................pl.......t.t...ht..stphht.........l.ltW..ph..Y.t...hhtp.tht...................................tpltshl....p.......ppL.ppahp..h.tphppa.htphhp.t-hp.t..a.p.....tt.Pp....................................p.pG......................hh..o..h.s.h..l.h.phl....p...pplphu.....................stshptphh..hs.lpth....thlpp..h.ppth..ph........hccphtt................................................................................thhhphhlAhhN.sp.thhp...........................h.ph...ppph...........t.................................th..tth.sshspl....tpp.......shphllp.la..D..lpshh......tcl.h...s.......pcWhss.................pshctlhsT.hpcah.t-hpp..lp....s.h..hph.hhtphtcpllhc.Ylptlhp....................................t+h.hp......tpp.....ppp.hsp+hh...p-hptlhthFpphs.........................p.h.p.hl.t..hhthl..............hps.s.l..........................h.tht..shhp.pa.sDh..p.p......altslL.thR....s.shspp.hptlht..htt................................................................................................................	0	97	158	257
+5875	PF06047	SynMuv_product	DUF926; 	Ras-induced vulval development antagonist	Finn RD	anon	Pfam-B_8083 (release 9.0)	Family	This family is from synthetic multi-vulval genes which encode chromatin-associated proteins involved in transcriptional repression. This protein has a role in antagonising Ras-induced vulval development [1].	25.00	25.00	40.30	40.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.34	0.72	-4.30	10	233	2009-01-15 18:05:59	2003-05-27 12:38:40	6	4	173	0	162	228	3	102.50	61	26.07	CHANGED	ppshsYGuALLPGEGsAMApYlpcGKRIPRRGEIGLTSEpIpsFEclGYVMSGSRH+RMsAVRlRKENQVYSAEEKRALAhhstEERtKREscllupF+ElIc++	......................s..hsYGpALLPGEGuAMApYVpp..G..K..RIPRRGEIGLTS-EIusFEssGYVMSGSRH..RRMp..AVRlRKENQlYSA-EKRALA.FNpEERpKREs+llusF+-hlpc..........................	0	68	90	125
+5876	PF06048	DUF927		Domain of unknown function (DUF927)	Finn RD	anon	Pfam-B_8364 (release 9.0)	Family	Family of bacterial proteins of unknown function. The C-terminal half of this family contains a P-loop motif.	20.60	20.60	20.60	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.85	0.70	-5.14	39	800	2012-10-05 12:31:09	2003-05-27 14:04:52	6	16	569	0	136	598	113	272.40	28	41.09	CHANGED	FpLs.....psGlhhhthscppps.......hhlsuPltlhAcscDs..p...stsauhllp.aps.DGph.+phshstplLtus.uschhtpLlshGhs.hsspt....hptLspaLpph.....pst.pspssspsGWp....ts.........sFlhscpsh..ussstp.lhh....pstpht..................tthptpGTlcsWpcpluphstGNshLhhul...usAhuusLL...phhs.hpusshHhhGsSSsGKoTshplAuSVaGsPs........thh+SWpuTsNuLEuhAutpsDshLsLDElupscs+-..sssl.lYhluNGpGKtRuspsGss..+sspp	........................................................................................................ptpGhhh.t...tppt.s...............hhlssPltlhsphpD...t.....sss.t.hllp.......sspp..pphs.hst.shl....spcthhpLhph..Gls.lssppt......ppL.spalpt......ssh.hsphsspsGWh.....tu...................................sal.h.s.s.p.l.....hss...s..tp......lhh.......sspsht.......................th.p....spG...Th.csW..pppltp..sp.G...N.h..l.h..hul....ssu.LuusLL......p.hs...hpuh..hhc...h.hGp....SSsGKo.TshplAs.S.VaGsPs..........hhpoWp.uTpNuLEuhAutps.sh.lslDE...l....u....p..s........ss..+p.........sssh.hYsl....ssGpGKtRushsGps..+s.p.t.............................................	1	49	87	118
+5877	PF06049	LSPR		Coagulation Factor V LSPD Repeat	Yeats C	anon	Yeats C	Repeat	These repeats are found in coagulation factor V (five). The name LSPD derives from the conserved residues in the middle of the repeat.They occur in the B domain, which is cleaved prior to activation of the protein. It has been suggested that domain B bring domains A and C together for activation ([1]).	30.00	1.60	33.50	1.60	29.60	1.50	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.07	0.77	-5.52	0.77	-3.41	33	291	2009-09-16 13:35:40	2003-05-27 14:42:21	7	11	8	0	203	308	3	9.00	64	11.44	CHANGED	oLSPDLsQp	.TLSPDLuQT....	0	0	0	0
+5878	PF06050	HGD-D		2-hydroxyglutaryl-CoA dehydratase, D-component 	Finn RD	anon	Pfam-B_8369 (release 9.0)	Family	Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalysed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate [1].	28.40	28.40	28.60	28.40	28.20	28.30	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.25	0.70	-5.63	163	2269	2009-01-15 18:05:59	2003-05-27 14:48:43	8	13	1163	10	497	1880	94	306.50	21	44.28	CHANGED	hshhsPpElltAu.sh.l...sht..l...........tht.phhh.sstppslssshCshl+s.hu...............................sshh.hschl..l..ssssC-spp+hhp..hhsphts.................hhhhchPpptpp............t......shphatcphc.c..........lhttlcphpupplsp-tl...tpslchhsptcct.hpchhcht...tthPsslss.tphh.hlhptthh.hs.tthhphhptlhschptth.cts.h.........tptthRlhlsG.sPhh.sshph..phlE.psGshllspphsh......sh+hhtshl.ts....................s.luc+hh.p.hss..sh........pp+hctltchhccaps-GllhhshphCcshs..............htthhlcchlcct.slPhlhl-sDh....pssshuplpsRlcAFhE.l	................................................................................................................phhh.pclhhAA.sh.s........sht....L.........................p.h...p.p..ht.pslstshsshl+p.hs..........................................................................................sshh..h.sshh..l..spshss.sph+hhp...hhu.tht.........................................hhhhphs.p.pt....................t...........shthhp..pchp.c........................................lh.plp.hhsp.......l..scpsl.....t.slt..l.hsptpct.lpphhchs...........tt.P.s.lss...tphh.t........hl...hsupat...h..........pphphhhs.pht..tth..ctsph.........hpsh.+h..h.hss.hPhh..s.ph.......phlE...ps....Gh.....shp....sh............hh+.h.h.thh.ts...................................l..hpphh....t.hsh................ctcht.hpphhccap....csl..hthhhpt.sp.sht.....................h.p.h.lcch.lcp...s.lPhh.l-s-.......psss.sGplhs+hpshhp..............................................................................................................................................	0	271	417	461
+5879	PF06051	DUF928		Domain of Unknown Function (DUF928)	Finn RD	anon	Pfam-B_8442 (release 9.0)	Family	Family of uncharacterised bacterial protein.	21.00	21.00	21.10	22.30	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.42	0.71	-4.70	25	177	2009-01-15 18:05:59	2003-05-27 15:01:16	7	5	39	0	58	178	1	184.20	25	72.24	CHANGED	pptGGu...........oRGs......Cs.........tsptsLTALlP...p......ss......hGlTssppPThah....YlPtssssts...pFs....LtD-p.scplYpss..hslss.psGIlulsLP..ssss.sLphGcsY+Whhs..lhC..sspssuss......hVcGhl....pRVphssslppplppss.shcpsslYAcsGlWYDsLssLA.pL+pspPpsstltpcWppLLc..SlsL.pplustPll	..................................t.ptuuuoRss........C.............tsp.s.lssLlP...tsp................................hGhTsstpPThah....YlPtssspph........................pFs........Lh..-pp......p...p..lYpps................hs.l...s...s..p.......s..GIlslsLP......tsss..sL.......cs.s...ppYpWths..lhC....sspsp.s..ss...............hVpGhl....pR..lp.hs......sslpppl.........pp.........ss...s..........hppstlYAp....pGlWaDsLspLu.plppppPps.thtttWppLLp.....ulsL..ptlsp.sh.......................	0	3	38	58
+5880	PF06052	3-HAO		3-hydroxyanthranilic acid dioxygenase	Finn RD	anon	Pfam-B_8515 (release 9.0)	Family	In eukaryotes 3-hydroxyanthranilic acid dioxygenase (EC:1.13.11.6) is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid [1].The prokaryotic homolog is involved in the 2-nitrobenzoate degradation pathway [2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.95	0.71	-4.79	5	387	2012-10-10 13:59:34	2003-05-27 15:14:34	7	5	349	8	226	543	220	145.40	44	74.95	CHANGED	MhslssINlcpWVcEN+GsFpPPVCNKCMH.p-QLKVMaVGGPNpRKDYHIEEGEEaFaQLKGDMVLKVlEcGssR....DllI+pGEhFLLPuRVPHSPQRFANTVGLVVER-RhssEpDGLRaYVusoscsLaEcWFYhpDLGTQLsPlIc-Fa	..................................................slNl.pWl-ENpcLL.pPPVs.Nhpla......p.s...s..ahVMlVGGP..N.tRp.DYH......l.s.p.s................E.a.FYQhcGsMhL+.lh.-..c.....G.....ph..+.....D.l..I+EG-hFLLP.................uplPHSPtR.h.u.sT...lG.LVlERc.R..p.s.p.h.DslcWYC...s..p......C.......s......c............h......laEt.F.h...p..D..lsTplhshhpcF.................................	0	68	127	184
+5881	PF06053	DUF929		Domain of unknown function (DUF929)	Finn RD	anon	Pfam-B_8458 (release 9.0)	Family	Family of proteins from the archaeon Sulfolobus, with undetermined  function.	25.00	25.00	32.80	32.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.87	0.70	-5.29	18	134	2009-01-15 18:05:59	2003-05-27 15:16:42	6	2	92	0	25	86	8	229.60	41	83.04	CHANGED	p+llhlslllllll.lllhlhhsph...............l..t.........spsshs....phhKlSspshussGpstlhaloW.GCPhGAssSWsLYlALp+aGsl..slphphSss........scshsshPGLlFhsa.s.....p..lpFpshY....lYsphlsto.hNGpsl....sphlthG.p.lppp.....lPstlYpllppYpsps..........s.s......Hls.sIlIoGstGoYhhsGs...ls...Pshl......Ssh.......sssYVlpp.Lcsss.......IhsuAshIpphIpc	..........................+lhYlslulLAls.lIIhuslltlppopps.........................................................hps.pstlucAlsSIspssYspVusGo.....plsKl..u.N.p..s....s..pcG..KVclaYVGuEaCPaCAhERhPLssALSRFGsF.SuL+splSSP.......tp+phuNIPTlTFcNY................................cYoSpY........Vsh...-uhEhu.DRpGc.I..................us.....LPpstpslasc..Ysstp...........................uIPFS.hhGshssssP...Sh....Phhh..............pc.....sPptVlcs.LsNPNStpAp.tIluuANLhTApICp.......................................................................................................................................	0	5	10	23
+5882	PF06054	CoiA		Competence protein CoiA-like family	Finn RD	anon	Pfam-B_8535 (release 9.0)	Family	Many of the members of this family are described as transcription factors.  CoiA falls within a competence-specific operon in  Streptococcus.  CoiA is an uncharacterised protein.	20.30	20.30	20.40	20.50	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.47	0.70	-5.57	14	1177	2012-10-11 20:44:44	2003-05-27 15:38:20	6	7	1110	0	142	756	21	285.00	25	86.93	CHANGED	M...L.sAhsppGphlslhpttp.p.......cppaaCPsCtuplhl.....KpGphhhsHFAHcshpsCphhtEsEStpHLtsKthLYpalpp.pc.p.................VplEhYlsElpQhsDlhlNpp...........................................lAlElQCSplshpclpcRTpuYpptGhpVhWllG....pplhhpc............................ploplppphlahsp.shshahach-ht..cph+h+ahhhpcltG...................................................+hahtpcphsht.sphhphhp........................................hsa.pp.h.ph.h.h..pht.hIppplhhtp.h.hp.pc..........chYp................pGpsllphhhtsha......................................htshp.h...p....p...pthhphpp.slchahcsa......................hhhhpcptpt.hpplhsshahhp..h	........................................M...h.hAhstptph.l.h..hp.....t.............cptahCPs....CtppVhL.....+.pG...p....hhsH...FAHc.p.h.p.s.C..p....h..h.........E..s.........ES..cHhtsKthLhp..hhpp..ps.p.........................................Vp...l.Ehh..L.......sc...l.p....Q...hsDl.h.l..sp.p...............................................hAl.El..QC.Ssls.......cplhcRopuYpphGhpVhWl..LG.............pph..hhcp................................................................................plp.h..p.h.thh...hhs....ph..thaha.ph..p....p.hhhha.hh.p......ts............................................................................................................................phah.t.......pth.....tph.plhp....................................................................................p.....h..h...h................h..l.p.p.h.........................hh...................t..h........h.............................................................................................................................................h..........................................................................................................................................................................................................................	0	36	78	111
+5883	PF06055	ExoD		Exopolysaccharide synthesis, ExoD	Finn RD	anon	Pfam-B_8604 (release 9.0)	Family	Among the bacterial genes required for nodule invasion are the exo genes. These genes are involved in the production of an extracellular polysaccharide.  Mutations in the exoD result in altered exopolysaccharide production and defects in nodule invasion [1].	22.10	22.10	22.70	47.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.96	0.71	-5.18	82	395	2009-01-15 18:05:59	2003-05-27 15:49:10	7	1	292	0	170	394	61	182.00	27	87.18	CHANGED	pslsshLcplt....................psppsph..olt-llcshGc+uFusl..lllhuLhhlhPls..lPGhs.olhulhlhlluhQhlhGRcphWLPphltcRplspcplppslpphpshsph.l-+hh+s.RLphlssssh.hplhsuhslhlsshh.hL.h..lPFssslP.uhAlslhululhsRDGllhllGhlhshsshshhshlh	.......................t..hsphLpphh................t...ptpsspl..olt-llstlucRu..FGhl..lllhuLPshlPls...PGho.slhGlslllluhQhhhGpc.psWLPphltc+slpppplpthlpphtshlpp.lE+hh+P.Rlthlssshs.tpl.hGlhlhlhulhlhLP....lP.h.oNhlP.uhulhlhulGllpRDGlhhlhGhlhshhshshhhhh.h...............	0	48	110	136
+5884	PF06056	Terminase_5		Putative ATPase subunit of terminase (gpP-like)	Bateman A	anon	Pfam-B_7152 (release 9.0)	Family	This family of proteins are annotated as ATPase subunits of phage terminase after [1]. Terminases are viral proteins that are involved in packaging viral DNA into the capsid.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.65	0.72	-4.41	16	859	2012-10-04 14:01:12	2003-05-27 16:53:51	7	16	638	0	101	1339	101	56.20	37	11.50	CHANGED	-sRcpAphLYapGapss-IActLshp.stTVauWpcR-pWcshssl.pplptulcsRlsp	..................-sRppAt..hL.Y..a....Q...G....a....ps.s.cIAchLsh...........p..ssTVauWKc.RDp.WcchsP..l..pphp.shtuRhhp...........................	0	19	53	78
+5885	PF06057	VirJ		Bacterial virulence protein (VirJ)	Moxon SJ	anon	Pfam-B_7524 (release 9.0)	Family	This family consists of several bacterial VirJ virulence proteins. VirJ is thought to be involved in the type IV secretion system. It is thought that the substrate proteins localised to the periplasm may associate with the pilus in a manner that is mediated by VirJ, and suggest a two-step process for type IV secretion in Agrobacterium [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.15	0.71	-4.52	12	339	2012-10-03 11:45:05	2003-05-28 10:33:45	6	5	263	0	92	319	18	180.10	39	47.26	CHANGED	pDphAlhhSGDGGWR-lD+clustLQppGlPVVGlDSLRYFWsERoPppsAsDLsRlIchYpc+WpsppVlLlGYSFGADllPtsaNcLPssp+spVp.huLLuLu+psDachplpGWLGhss-Gtt.s.ss-ltplssshl.ClYGp--cD.ssCPsLctpss-sluhsGGHHFDtDYtsLAcpllsuhcsRh	.........................DhlslhhSGDGGW.R.-lDKsluptLpppGlsVVGlD..........S..L..RYF.W......s....c+....oP.....pph....AsDLsclhppYptcWttp...cl...hL...lGYSFGADlhPhsascLsss.psplphlsLLuhu.ppusFplclpGWLGhssct....sssPtlspls.s..s.hlhClYGp-EcD...shCs..s.......pt.p.shchlpLPGGHHFDpc.Y.slAptllpthpt.t................................................................	0	19	38	64
+5886	PF06058	DCP1		Dcp1-like decapping family	Finn RD	anon	Pfam-B_8271 (release 9.0)	Family	An essential step in mRNA turnover is decapping.  In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2 (Pfam:PF05026).  The precise role of these proteins in the decapping reaction have not been established. Evidence suggests that the Dcp1 may enhance the function of Dcp2 [1].	20.60	20.60	23.00	20.90	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.34	0.71	-4.07	9	430	2012-10-04 00:02:25	2003-05-28 11:45:17	8	7	272	7	284	392	3	112.70	32	29.81	CHANGED	hspttppl...sLssLpphDPYIpcIlDhuuaVAlYpFssptscWpKs-lEGThFlYpRuspPhauahIhNRhshcshlEslspshchplpssFLlYR....ssp..pIhulWFYspp-sp+IhpLhppll	..............................................t...tppl...sLssLpRh.DP...h.IppIlph.uupsslYpFs.p......s.s....p.WpK.p-..l.EGoLF.l.....h.....p....R.......s.........s....p........P..........p.......a...shhlhNR...hs...h..........c.Nhscs.l..........sp..s....h.-...hp..lpt..s....a..lla+.........................ssp....pl.hulWFaspp.-pppl.thh...................................................	0	76	137	220
+5887	PF06059	DUF930		Domain of Unknown Function (DUF930)	Finn RD	anon	Pfam-B_8283 (release 9.0)	Family	Family of bacterial proteins with undetermined function.  All bacteria in this family are from the Rhizobiales order. 	25.00	25.00	32.90	45.10	19.90	19.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.23	0.72	-3.77	20	145	2009-01-15 18:05:59	2003-05-28 11:50:12	7	1	106	0	50	101	3	99.30	44	51.86	CHANGED	ltpLssppRlpQlCssEAhcplt+spssapPDplsuashssshhsGsslcAsGAAFRSpspWYclsF+Ccsss-shsVhSFsaplGctIP+ucWschtL..hs	....Lc+L-PssRLEQtCDlEAME+Is+-pstapsD+VlAYuaucPhhptNolcAsGAAFRS+pcWY+LuapCcsDs-phslpSFuYtIGsclPp-pWc++hLh.P..	0	7	23	32
+5888	PF06060	Mesothelin		Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)	Moxon SJ	anon	Pfam-B_8552 (release 9.0)	Family	This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known [1,2].	17.50	17.50	17.60	17.50	17.20	16.80	hmmbuild  -o /dev/null HMM SEED	625	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.30	0.70	-13.09	0.70	-6.47	3	103	2009-01-15 18:05:59	2003-05-28 12:04:28	7	2	42	0	65	83	0	409.20	29	80.15	CHANGED	MALPTARPLLGSCGSPICSRSFLLLLLSLGWlPhLQTQTT+TSQEAALLHAV.sGssDFASLPTGLFLGLsC-EVSGLSME+AKELAMAVRQKNIsLpsHQLRCLARRLP+HLTsEELDALPLDLLLFLNPAMFPGQQACAHFFSLISKANVDVLPRRSLERQRLLsuALKCQGVYGFQVSEADVRALGGLACDLPG+FVA+SSEVLLPWLAuCsGPLDQuQpKAVREVLRSGRsPYGPPSTWSVSTLDALQGLLsVLDESIV+SIPKDVlAEWLQ+ISRDPSRLGSKhTVlHPRFRRDsEQKACPPGKEPpcVDEsLIFYQNWELEACVDGTLLAsQMDLVNEIPFTYEQLSIFKHKLDKTYPQGYPESLIQQLGHFFRYVSPEDIRQWNVTSPDTVKTLLKVSKGQKMs........AQVIALVACYLRGGGQLDEDhVKALssIPLSYLCDFSPQDLHSVPSSVMWLVGPQDLDKCSQRHLGlLYQKACSAFQNVSGLEYFEKI+TFLGGASsEDLRALSQHNVSMDIATFKKLQVDALVGLSVAEVQKLLGPHIsDLKTEEDKSPVRDWLFRQ+QKDLDoLGLGLQGGIPNGYLVLDFNVREAFSSsAsLLGPGFVLsWIPALLsALRLS	.....................................................................................................................................................................................................................h..h...hh..h...................C..hh..h.t.thp.h..t..s....t.t.l..tuhtC......t....h.t....................lsttph.h.........LGsLsC....sh.sst.l......t....us.....lL..tL.tC....ls.sQt.uhp..hl.ttts.hG.Ps.Ws.tslptLt.L..h........ht..........h...h.th.........p.........th........hh......h.h......t......t.............t.................t.....h.........................t........h..............h..p........t.t......tt.............h......s.............s..t..l...pp.p...h..h.h...Ypp......p.hcs........ClssthLtsp.hs.l...th.sh.shpp.plhKt..KLsphY..Pp..G.hPEs.lphls.hhhhh.o..p-ItpWslTS.-TlhuLLt.s....s.......p...............spstsllt+a..lttt.G.p.lstshh....h..h.s.t.hLC.hs.pplpsl...sp.hh.h.st.s..clssCs..pphslLas..KAc.A...F......t.....s.......s..t..s.....t.Ya.hhpsaL................G................G.As...........h.....p-LptLuptNlsM...DhsTFhpLp.p.l...LsltpVptLLG.pl.sLpt.cpps.lptWh.p..pptLst.LGls...........................................................................................	0	4	14	26
+5889	PF06061	Baculo_ME53		Baculoviridae ME53	Finn RD	anon	Pfam-B_8086 (release 9.0)	Family	ME53 is one of the major early-transcribed genes. The ME53 protein is reported to contain a putative zinc finger motif [1].	25.00	25.00	121.70	66.10	23.40	20.20	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.36	0.70	-5.45	21	63	2009-01-15 18:05:59	2003-05-28 12:06:23	6	2	54	0	0	62	0	311.00	28	87.23	CHANGED	+DLRh+FLSpps+plhpull+FAoNYVpGhhpspshh.hsp.t.hphc......hsppopCs.tCtt+F+csschh....Lasllcp.h...s............ssp.s+FchsCpcCtppht.....phssaplYPplsLtslccLsctGFhppYlFPlchchppppcphhhhst....cshacslcpIlpc.KcsNEpIhpIsLp..ThGtllhpEs.psshlc+hps.h.t...ss-ls..hhsssSphhphlpspt.ps..hTYFhEVht+sapph.hs..alsahs+sstth.....CphC+.sKhY..cps....PVLaCS+CGFTsshaFp.....p...hsslhap.csVp..spp...hpsptlhYYDlshat	......................pDLRh+FLSppppplhpuhlcFAssYlpGhhp.pph..hth.t....p.......hhppopCp.pCptpF+pspp.........hLasllcp.h................sspss+F+hsCtcCtpphph........hslhELYPslsLtsVc+LsphGFlp+YlFslshshphpp+phhlhsh....pclapslppIlpp.KpsNEpIppIpLp..ThucllhcEshpshhlcptpp.......ss.lp..hh.tsSphhphlpstp..s..hTYahcVhh+happh.hs...alsaashsspt......CphCp.sKhY..psp.....PVLaCSpCGFTsshaFp.........h.pphtYh.ppVp....hpp.....h+sp..tlhYYDhphh................................	0	0	0	0
+5890	PF06062	UPF0231		Uncharacterised protein family (UPF0231)	Finn RD	anon	Pfam-B_9027 (release 9.0)	Family	Family of uncharacterised Proteobacteria proteins.	25.00	25.00	25.00	25.00	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.54	0.71	-4.23	38	786	2009-01-15 18:05:59	2003-05-28 12:11:05	6	3	779	0	93	332	7	116.70	58	95.91	CHANGED	M-YEFp+s.lsGphhAchSMsHEslGpWhsEElupshpplsplhstIpplcsuptt..-hpLhGpEhoLhlss-ElhVpAN.....sLth-..p-.EhE-shphYDpESh.AhCGLEDFpphLpuWpsFlp	............MDYEFLRD.lTGsV+VRhSMGHEVVGHWFNEEVKcN.LuLLDEVEpAA+slKGSER...sWQpsGHEYTLWhDGEEVMV.RAN........QL-Fu...GD...EM..EE.G.MsYY...DEESL...SLCGlEDFLpVlsAYRsFl....................	0	8	29	63
+5892	PF06064	Gam		Host-nuclease inhibitor protein Gam	Finn RD	anon	Pfam-B_9063 (release 9.0)	Family	The Gam protein inhibits RecBCD nuclease and is found in both bacteria and bacteriophage [1].	25.00	25.00	34.10	34.10	20.20	18.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.33	0.72	-3.89	2	349	2009-01-15 18:05:59	2003-05-28 12:30:04	6	1	243	4	3	150	1	94.40	91	97.43	CHANGED	MNAYhh.DRlEAQsWsRHYQQlAREEKEuELADDhEKGLs.HhhESLChDcL.RHGAsKKuIoRAFDDDVEFQERhuEalRYMsEThu+HQlDI-SE.	.........MNAYYIQDRLEAQSWARHYQQIAREEKEAELADDMEKGLPQHLFESLCIDHLQRHGASKKAITRAFDDDVEFQERMAEHIRYMVETIAHHQVDIDSEV...............	0	0	0	1
+5894	PF06066	SepZ		SepZ	Finn RD	anon	Pfam-B_9064 (release 9.0)	Family	SepZ is a component of the type III secretion system use in bacteria. SepZ is a gene within the enterocyte effacement locus. SepZ mutants exhibit reduced invasion efficiency and lack of tyrosine phosphorylation  of Hp90 [1].	22.70	22.70	22.80	72.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.19	0.72	-4.00	4	76	2009-01-15 18:05:59	2003-05-28 13:21:08	6	1	53	0	1	38	0	96.70	75	99.39	CHANGED	M-AANLSPSGsVLPLAsoINGNssVDEsTGVMpPENGssRslRlhAGlALusoALAAlGsGIAuhCs-suSpp.hLGLGIAuGVLGGlTulGGuLAMKYA	.M-AANLSPSGuVLPLAATINGNsSVDEpTGVMpPENGsSRslRIlAGlALuTTALAALGTGIAhACopsuSop.aLGLGIAoGVLGGVTAlGGGLAMKYA	0	0	0	1
+5895	PF06067	DUF932		Domain of unknown function (DUF932)	Finn RD, Pollington J, Bateman A	anon	Pfam-B_9083 (release 9.0) & Pfam-B_002957 (release 23.0)	Family	Family of prokaryotic proteins with unknown function. Contains a number of highly conserved polar residues that could suggest an enzymatic activity.	20.10	20.10	20.40	20.10	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.48	0.70	-5.06	43	1425	2009-01-15 18:05:59	2003-05-28 13:23:55	6	4	644	0	189	1175	404	205.70	51	80.09	CHANGED	sLushSsRYphlpspplL.....psLpccu.t...shhpotutl+s.GR+has..hhRhtcsspl.......ssthss.llLhsSHDGosuhphhhsshRlVCsNTLshu..usssu..sl+V.H..psssshclt-utpplt.h..pta-phptphcthtphplsps-tpsahpsslshp..................s.tpstpssstshsplhphhcscsp........psohWushNuVsEals+tths.Rss...............cp+tspultGh..sspLpptta	...............................................................HpSRSc.+YsYIPTIslL........csLpcEG.FQ.....PFFACQoRVRD....GRRtaoK.HMLRLR.R.supI.........sGpclPEIILLNSHDGoSSYQMlPGhFRhVCpN...GhVC.....GpshG........ElRVPH..+Gsl..V...t.c..VI.E.G..AYEVl.............u.....lFD+lp-pt-AMp.....slhL..ssst..ppshApAALshR...............................Ys......-c+pPV..Tssp.IL..o.P.RRpEDh.............tpDLWosaQplQENh.lKG.Glo..GRSA.........pG........++h+TRAlpuIDsDl+LN+ALW...............................................................................................................	0	37	102	151
+5896	PF06068	TIP49		TIP49 C-terminus	Moxon SJ	anon	Pfam-B_9170 (release 9.0)	Family	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2]. 	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.24	0.70	-5.75	16	859	2012-10-05 12:31:09	2003-05-28 13:25:51	8	13	383	10	602	1792	868	352.50	52	84.15	CHANGED	RIusHSHI+GLG......LD-sh................................................................pscpsup.........GhVGQhpARcAAGVIlchI+ptKhuGRulLlAGsPGTGKTAlAluIucELG.pcsPFsslsGSElYSsEhpKTEsLhQAFR+uIGlRIKEppEVhEGEVV-lph....-pPhs...spshptsplsLKTschppphcLusclhEsLpKE+VpsGDVIhI-psoGplp+lGRS.stup-aDl..psscaV.hPcGElpK+KElVpsVTLHDlDV.hNuRs...QshlulF....pscpsEIpsclRppINchVscalEpGpAEIVPGVLFIDEVHMLDIECFoaLNRALESshuPIllhATNRGhspIRGT.DhhSPHGIPhDLLDRlLIIsThPYsccEI+pILcIRspEEclpls--Ah-hLscIGpcoSLRYulpLlssApll	.....................................................................................................................RluuHSHI+GLGLc.p.s.h............................................................................................p..sc...s.up.......................Gh.VGQ..pA.RcAu.Gll.l.....c.hI......+p.......tK.......h...A..G.......R...A...l...L...lAGsPG......TGKTAlAhuluQp...LG...scsPFsshsGSEl.aShEhpK....................TE.s.Lh.ps.FR+uI.GlRIKEp.pElh....EGEVsElp..............-p.....shs.........spsh.ppshl..sL.KT..s.chpphhcLssphh-ulpKE+VpsGDVIhI-tsoGtlp+lGR.S...s..h..u..p-..aDh...............tsp.c.aV.hPcG-lpK+KElV.psVTLH-lDV.h.NuRs................Qsh.luhh....pscpsEI.psclRppINp....h..Vscah-pGhAElVPG....VLF.IDEVHMLDIE...CFo..aLNRALES.sh...AP.I.V..Ih.A..oNRGhspI...RG............T.....s............h..pSPHGIPlD.LLDRllI.Ip..T.sYstcElc.pIlp...........IRupp.Eslplsp-.A.lshLs.clGt...coSLRYAlQLlosApl.l.............................................................	0	228	347	506
+5897	PF06069	PerC		PerC transcriptional activator	Finn RD	anon	Pfam-B_9117 (release 9.0)	Family	PerC is a transcriptional activator of EaeA/BfpA expression in enteropathogenic bacteria [1].	22.50	22.50	22.80	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.02	0.72	-3.95	4	532	2009-01-15 18:05:59	2003-05-28 13:31:51	6	3	323	0	17	287	0	72.20	37	68.03	CHANGED	M.l+D+lAcpLEtKGhYRRAA-RWucVMl.lp.oDtcR+hss.+Rs.ClpKup+sPls.s.Nho-l+pAVs+sapcMGlshsscclFRpYpss	...........h.....phApcLEu+GhaRRAAshWhtshtpsc.o-spRp.hhtRRppCLpKuu.......+......shs.......................................s.....................	0	1	1	8
+5898	PF06070	Herpes_UL32		Herpesvirus large structural phosphoprotein UL32	Finn RD	anon	Pfam-B_9125 (release 9.0)	Family	The large phosphorylated protein (UL32-like) of herpes viruses  is the polypeptide most frequently reactive in immuno-blotting analyses with antisera when compared with other viral proteins [1].	25.00	25.00	55.60	55.40	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	839	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.42	0.70	-13.57	0.70	-6.08	9	59	2009-01-15 18:05:59	2003-05-28 14:01:11	6	2	25	0	0	58	0	674.30	31	98.07	CHANGED	Ms.....LsFltLs++sVspLspFLcsL.pcssVDLcpHP+llpcC...stcpLpRcosLaNpLlLWLtYYcpLph+pPDhpsLhc-hchptsslschspthshhp.spuhscLsslspssFts-hpscscll.pshhs...LA+h...tttp.lshG......hsFlNL+sc-spclccNLpssppNMhphpslcls..pptNssLVsslNKLlYLG+lllslppSWpcLpctCLs+Ipphp+pLl+pl+pshuFsusYspNlLc+sV.-GpospslLchLtEDasIacsu...............LEasD................................................................................................................................shpSpp-cc--.sssp..shh.................................................................................s.ptssh.sp-Esssccc.t.tu.tst....sppp..soh..Dlpsuspsst.sss.tsspothh.E...........................Pttustss.s.ph.u.....s.p.Phhuss..ssphsP.p..........s...thshtsshh..........hss.s.hs.s..shstshsshsshchpspsth.sp.p.PsspcsosssophssspR....tsps......p.sspspEshss..pctpsoDspsVhphtph..t..h.......sspssp+ucpphhht.phssstssss......spspPshs.h..sssssshsphhp.s.....h.ss..ph+shtsh.spshss.sosl+P.shssts...sssptlssspsssssttsthPuutus.........................p..p..............st.thpss.utph.....................hpssshscl.tthsthshtssssus..hp...........s.hopthsuss..........................................stsshsthtsspss--sltsllp+hptctpp........................pc	.........................Mu.LtFltLp+psVstlhpFLppL.ph.slsLptHP+lltcC...ttppLpRcohLaNchhLWLtYaccLph+pPD...hpslLpchc.ptstlsphs..hshP.hs..thcuhsclslh-cs...atsDhh.cs-l.l.+ul.s...LA+h...ph.p.hspuh.....huFlpL+sp-Vpclt-NlcsstpNhhhhcslclp.shp.ssshV.shN+LlYhG+LhhslppSWppLpchCLsRIpphp+hLltth+.p..uFspsYspNlLc+sV.sGsoA.sLLchL.EDFtlahsu..................LcasD.t.......................................................................................................................hhhpSt.-scs.Dss-..............................................................................................ttssh..t-..Esssptt..........................D.tss.tph...........................................P.hu.tssss..t.ssh.s.sstppshssst..shphpP..................h..ssh...........hss.t.................phphsspsps.sp.p.Psp.pssss.ou.psstt.....shu....tsctsspcpEt......c.s.puoDstpVhphtc..............ssphspp....up.phhhthphsp..Ttss......sppcP.ht.hh.ss.ssshsphhtss..............php.tp.h.sss.ssssohl...shssth...sp.p.l.ssttsps.t.st.Pputsp.........................p..p.s.....p.......ss..hhsp.usph..........................hpsh..shpth...psstts...............s.hotthtut.............................................................................t.............................................................................................................	0	0	0	0
+5899	PF06071	YchF-GTPase_C	DUF933; 	Protein of unknown function (DUF933)	Moxon SJ, Studholme DJ	anon	Pfam-B_10000 (release 9.0)	Domain	This domain is found at the C terminus of the YchF GTP-binding protein (Swiss:O13998) and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies. 	20.10	20.10	20.70	20.50	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.65	0.72	-4.19	44	5012	2012-10-03 10:59:06	2003-05-28 14:04:36	8	16	4777	7	1296	3379	2253	82.60	63	22.65	CHANGED	LtTaFTsGscEVRAWTI+pGspAPpAAGlIHoDFE+GFI+AElluY-Dhlph.s...oEstuKEsGKhRhEGK-YlVpDGDllpF+FN	..........LtTYFTAGsc.EVRAWTI+pGspAPQAA.GlIHTDFE.+GFIRAEslu.Y........-Dhlp.h....s......uEpu..............A..KEAGKhRhEGK-YlVpDGDlh.pFRFN..................	0	463	849	1106
+5900	PF06072	Herpes_US9		Alphaherpesvirus tegument protein US9	Moxon SJ	anon	Pfam-B_7164 (release 9.0)	Family	This family consists of several US9 and related proteins from the Alphaherpesviruses. The function of the US9 protein is unknown although in Bovine herpesvirus 5 Us9 is essential for the anterograde spread of the virus from the olfactory mucosa to the bulb [1].	22.40	22.40	22.40	44.00	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.01	0.72	-4.14	10	46	2009-01-15 18:05:59	2003-05-28 14:28:17	6	1	28	0	0	46	0	57.90	49	47.07	CHANGED	CYYSESDNETAs-FL+RlG++Q.spR+..RRRpChlsluhlhsslllCslSuhLGulluhhl	CYYSESDsETAs-FLhRhGRpQ.shR+..RRRRshhsluhlhsslllsslSuhlGulluhhh..	0	0	0	0
+5901	PF06073	DUF934		Bacterial protein of unknown function (DUF934)	Moxon SJ	anon	Pfam-B_8947 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function. One of the members of this family Swiss:Q8YEW3 is thought to be an oxidoreductase.	25.00	25.00	25.20	25.10	23.70	23.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.45	0.72	-4.36	75	595	2009-01-15 18:05:59	2003-05-28 15:08:50	7	3	527	0	191	481	128	109.70	38	66.70	CHANGED	GVhlss---sc.pL....ts..pLspl..sllAlsFPsFsDGRuaSpApLLRcRhGapGELRAlGDVLhDQlhaMpRsGFDuFslcs....stshpsAhc.shscFosh....YQsuss.....pstsha..pRp	.....................uVhlssc--sp...sL....ts......cLspl..slIulpFPsFsDGRuaShAcLLRpRhGapGE..LRAhGDVLhDQlhahpRsGFDuaslcs....cpshc....c....shc....sh....scassh....YQsust....t..s.............................	0	42	107	148
+5902	PF06074	DUF935		Protein of unknown function (DUF935)	Moxon SJ	anon	Pfam-B_10021 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function as well as the Bacteriophage Mu gp29 protein Swiss:Q9T1W5.	20.30	20.30	22.30	21.70	19.90	20.10	hmmbuild  -o /dev/null HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.43	0.70	-5.79	54	588	2009-01-15 18:05:59	2003-05-28 15:19:29	7	5	459	0	91	595	77	428.60	21	92.12	CHANGED	M.sp...........s.ht.....t.ttphpsph..tthshhtt.h...psupGlo.sschssILcsstpGs.lps.t-Lh..h.t+DsHltuplppRKtAl.....hul-Wplpssss.sstcp+hA-hlc-hlpchs...........hccllh-hhDAlhhGaushEl.hW..tpps...shahspslph+s.caFphsppst..........cl+hpsss.......Gp...L.shpalh+pp+ucss..shttGLh+hlhWsahFKphul+.aspFhEhYGhPhtlGKYss.uAspp-+ss....LLcAltslspsAuulIPcsMplEhhcAus....uusssapphlcas-pplSKAlLGQThT..op....sssuspAtuplHs-VRcDlhpuDsc.lspTlsptLltslhtlNh...tsstphPphph.ppEstDhpt.......hu-shppLssh.Ghchst...pahp-chsls.sptspsshshsstss............stth.........................................stttt.t................pstlDshhsph............hsphpts.hcshlpslhshlppusoh--hhppLh.phh.sphsssphtchlucuhhsAclhGphss	..................................................................................................................................................................................................................................................................................................hh....p...hhpt.tts..........plh.....p...DspltuthtpR+tul.....hshphpl.ssps...........t.tchlpchh..pph...................hp.ch.lhphh.-ulhhGaushEl...a..............thps.........th.hh.ttlhh+s....p...h.F...t...hs..p.s.t...................h.hphp.ss....................G..........l..s...hta.lhth.hp.upts.....t.uLhphhha.hhhKphulc.ahpFhEh..a..G..h..Phh...lGKhss...ss.....spp-hpp..............L...hpu...ltp...h..s.ps..u..u.ul.......lPp.............s..............p.............l..-....hhpsss......sssssa..p..ph.hcat-pplu+slLGpsl..T..op....spsuohAhupsHp-.....Vpp-lhpuDsc.lttslsptll............h.......hhtlNh.........sspthP.ph.htt...p...-s.tD.....hpt............hupth.p.L.s.s.h.G.h.p.lst.....pal....pcph.slststtt.p.thht....s......................................................................................................................tp..hpthhtth...........htt..ht.hht.h......th...ht....t.ts..tth.......t......tl.............t.h..phs.tth.......p.ht.hh..uph.G..................................................................................................................................................	0	39	71	83
+5903	PF06075	DUF936		Plant protein of unknown function (DUF936)	Moxon SJ	anon	Pfam-B_10047 (release 9.0)	Family	This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	20.10	20.10	21.60	20.80	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	580	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-13.03	0.70	-5.59	13	173	2009-09-11 12:47:55	2003-05-28 15:22:28	7	4	21	0	122	161	0	420.20	24	96.01	CHANGED	LsPGVLhKL.Lp..sMsos.lK..ssGEHRSu......LLQVhsIVPA.Luuu...-LaPspG.FalKlSDSoHSsYVSLss.-csDLILSsKlQL.GQFIaV-+...L-suoPVPll+GlRPlP.GR+Ps.VGsPcDLhusc..s.hpt.........................................................shppp+tssssRphshssss+p......................shsuSPssht.h.hshp..................phsptpsuhhhsup..hptsSPsstppsss........t...................Guuph+Kpssshst............stpsps+s.stppssttpsssspsPs+sp............ptth.tthpchshsssspssspospppss...t...................p.hphsstslsWsSLPssLs+LGK........EshcpR-sAthuAlcALcEAoAsEsll+sLptFoELop..suKt-sPtssl-pFLphappltpsphh.hpSlststsssstsp.......................pppsuhp.lpu...AlsTshsshslh...........................................ppp.sshpph..sth.pptppspsstpt..............ptsGls-oscLAppLppEupsWFLcFlEcuL-pG.hctp.............ptpssuclut......hLSQLKpVscWLDplsssppp..................-pl-pLR+KlYthLLpHVposAuulss	....................................................................l.sGlL.+l.lp...t.pss..p......sphRss......lLQVhtllPh.lstt.......p.h...tp.G.FhlplSDu.+uhYsp.s..tpt-hll.ssp.pl.Gphhalp+...l..p....u.PVPhhhsh+sls.tRt...h..hGs..Ptshh.........................................................................................................................................................................................................................................................................................h................t.............................................................................................................................................................................................................................................................t.........slss..l...up.....................thhp.+p.A..huhpu.p-A.hsp.llp.hp.auplp...ssp.tss..hhp.tFhth.t.h.p..h................................................................t......tt.t.....................................................................................................................................................................................................tthtt.hpLt..l..-.ttWFhtalEthL-.t..th......................ttpht.............hhps.pWlp..................................................................s...............................................................	0	14	78	104
+5904	PF06076	Orthopox_F14		Orthopoxvirus F14 protein	Moxon SJ	anon	Pfam-B_10072 (release 9.0)	Family	This family consists of several short Orthopoxvirus F14 proteins. The function of this protein is unknown.	21.90	21.90	22.40	125.40	21.00	17.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.50	0.72	-3.92	2	33	2009-01-15 18:05:59	2003-05-28 15:26:25	7	1	19	\N	0	20	0	72.90	86	100.00	CHANGED	MKH+lYSEGLpISsDhNSIIuQ.ST.DhDIEIDEDsIhELLNILTELGCDVDFDEsFSDIsDDlLESLhEQDh	MKHRlYSEGLuISsDLNSIIuQQS....ThDhDIEIDEDDIMELLNILTELGCDVDFDENFSDIADDILESLIEQDl	0	0	0	0
+5906	PF06078	DUF937		Bacterial protein of unknown function (DUF937)	Moxon SJ	anon	Pfam-B_7321 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	24.40	24.40	24.40	24.80	24.30	23.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.90	0.71	-3.94	89	984	2009-09-10 15:56:24	2003-05-28 15:43:14	6	6	888	1	262	664	43	125.00	30	71.04	CHANGED	l-plhu....t..htt............................hsthlGh.....................................................ssspsssuh..ssh..lssll.......uuh......ttt.sts..................................sGhsu........................Lhstlppssh......................................ssthtshlu..su.s.sh.............usshlsplhsu....psshsplupp...oGlst..spltphLshhhPhllshLssp	.................................................h.........................................................................................................................................................hstl..l.........Guh.....tt........t..ts...................................GGlps........................LlppL.ps.u..G.L....................................Gshl...s...o..Wlu....ptsNpsl...............uscp.Lpssl.G.....ssslssLup.+.........hGlss.spssshLuphLPpllDtLoPp............	0	53	152	207
+5907	PF06079	Apyrase	SHAPY;	Apyrase	Moxon SJ	anon	Pfam-B_7593 (release 9.0)	Family	This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. [1]. 	20.30	20.30	20.50	35.50	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.87	0.70	-5.26	20	238	2009-01-15 18:05:59	2003-05-28 15:48:53	6	4	129	8	104	237	2	249.00	43	77.24	CHANGED	LDpsStspcct..soWtShl++GpLphsssppslolcW-pt.pltlpS+huhKGRGMELSELlsFNGKLYolDDRTGllYcIpcs..cllPWVILsDGDGsssK...............GFKuEWsTVK-ppLYVGShGKEWTTosGphhNpNPhWVKsIshcG-VpphNWhspYcplR.sAhGIpsP.GYlIHEussWSsptppWaFLPRRsSpEpYsEptDE+pGsNhllousEsFpclcslcls..shsPs+GFSSFKFlPsTcDplIlALKopE.....csGp.sATYlosFsl-G+lLLsEp+I.sDsKYEGlEFl	................................................DptSt..t.p.tp..poahShl+hG.Lphs.......s...............s.t.plslch-.t...phhlpo.....phu.pGRGMELSELlhFNGKLYohDD+TGllac..l..ct......s.........c.........hlPWVILs-GDGs.s.p.K.....................................GFKuEWh...TVK.--cLYVGuh.....G+EWs.sspGphlspsshWVKhl.shpG.cVpphNWsspYptl+.p.AhGIp.P.GY.hhHEus.WSthhppWhFLPR+sSpp..Ys-t.DEp.h.GsN.hll.ss.t.sFtp.lp.s.pls.....h..st+GFSuF...........KFlPs....opDplIlALKo.E..........tsp..htoalhshsl.p.G.......phlh.-........p.l.ts.KaEGltFh..........	1	48	57	86
+5908	PF06080	DUF938		Protein of unknown function (DUF938)	Moxon SJ	anon	Pfam-B_8833 (release 9.0)	Family	This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.24	0.71	-4.78	6	529	2012-10-10 17:06:42	2003-05-28 15:51:31	7	5	465	0	233	728	387	188.80	39	90.05	CHANGED	+.aAPAspRN+-PILuVLpphlssssp...lLEIASGTGQHAsaFAsthPshpWQsSD.spphht.SItA....atcptulsNltsPlpLDlots.hsspt.h..........ssslDulhshNhlHISPWsss.GLFsGAGclLsptulLhlYGPYspsGchTusSNtsFDpoLRsRsspWGlRDlc-lhuLAtppGLpLpchlsMPANN+sllFp+	..................................husAs-RN+pP..ILp......V.L...pp...h..l....sss.sp..........VLEluSGTGQHusaF..At.th..........P......t..l....p.WQ.P.S.D.hstpt....ht...........SItA.............ah..t.p......s.....s.l..s.N.....l.t.s.P.l..t.L...D..ls.ts....a.sht..................................................shDulhsh..N.h.l.HIs..sas.s...s.pu.LFtuA..u............p.hLt.s........s..Gh.L........hl.YGPaphs.GphT.ut.SNttFD.t.pL+p+.s.P.t.h..Gl..RDhc.s.lttLAttpGLt......LtchltMPA..NNhhllap+........................................................................................	0	62	122	184
+5909	PF06081	DUF939		Bacterial protein of unknown function (DUF939)	Moxon SJ	anon	Pfam-B_8873 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.76	0.71	-4.31	33	2302	2012-10-02 19:04:43	2003-05-28 15:53:42	6	4	1115	0	242	2189	63	142.20	28	47.03	CHANGED	h+IGhRTlKTulussLAlhlAphL..sLs.hssAGIlsILslQsTppcSlpsuhpRhhuslluhlhuslhhtlhGa.sslshGlhlllhIslslpL+lp.cGlssusVlllplhsppshsahh.hhschhLlhlGlslAhLlNlaM	...............................plGhRTlKTulAshLu.h....l....l....s.t.h.L.............sl.s.....h....h.h....Au....l.s.A.l.l.u.l....p..s..oh.p..p.S..l.p.hu.hsRlhush...lG..shlu...l....l.....h......h...h.....l............h.......G........p.......s.......h....h.......s....h......u.....l....h...........l.....h......l......h....I.....s...l......s......h.......t.......h.......p........l........p........t...........G........l..........s..........s..........u..........s.....l....h........l....l..........t...........l.....h..........s..........t..........p..........s......t..........s..........h..........h....h......h....hsc.h.lh.hhIGlhh.AhllNhhh..................................................................	1	87	155	210
+5910	PF06082	DUF940		Bacterial putative lipoprotein (DUF940)	Moxon SJ	anon	Pfam-B_9128 (release 9.0)	Family	This family consists of hypothetical bacterial proteins several of which are described as putative lipoproteins.	21.10	21.10	25.80	24.90	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	658	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.83	0.70	-5.97	38	1147	2009-09-11 20:50:12	2003-05-28 16:06:17	6	5	706	0	120	707	920	573.90	47	92.49	CHANGED	sS.ssaGss.GLlpMPoARMts-Gphuhshsts.........sp..........Yp+asholQlhPWlEsohRYopl......psh.as.........s.h..SGsppapD+uhDhKhRLh..cEota.lP.plulGlcDhuGTG............lFsGEYllAoKph...........Gsh-hTlGlGWGhlGspsslsssh......h..spRs.t...htspGGplshspaF+Gssuh.FGGlEYQsPaps.LpLKlEY-ussYpp-hssp.....shppcSs.aNaGshY+hschhclpLuYp+G............sTlshuholptNh.....sshpss.hhsssssshpsp......ssp..............................................................tshpss...........................hpphhpphhtpsGaphtplt.hcss..slslthc..p.s+YcspscAhtRsApllusshPss.lcpa+ll.pptshPhsps..............plct.tthpshtphphh..s.sphtstsphsps...h.sps......thhppth.ca....sauluPhlsQShGsP-shahaslGlpssusYphssshhlsGslthslh..sNaDchph.............................sus.sLPRVRT.hRpYsppssspLspLpLsahtphupshYspshuGYLEpMauGVGuElLY+P.hsusaAlGl-hNal+QRDh...-shhGh.............t-hcs..........................hT.......G...HsosYap.s.....pshhhplssG+YLAsDhGsTlslu+pFcsGlhlGAaAThT...DlSu-EaGEGSF.sKGhalSIPhDhhhscPopspushshtPloRDGGQhLspphpLY-hTcsp	...........................................................SQSDFGGs.G.LLQhPoARMA.EGEh.SlNY+DN...............DQ.................YRaYSsSVpLFPWLEsTlRY..T..DV...RT+pYS........phEsF...SGDQoYKDKuFDhKLRLW...EE...u...YW...lP.QVAlGtRD.I...uGTG.....................LFD.uE....YlVASKth...........GPF.DF.T..LGhuW.GYhGsuGN.lpNPhCp.....hSD+aC.Rs............pp.AGslsh....SphF+GP.A.Sl.FG...GlEYQ.....T....PWpP...LRLKLEY-GNsYppDFA.G.........+L.QtS.+..FNVGAlYR.s.s.sW.ADlNL.SYERG............N.ThMFGhTL...RTNF.....NDLRPs..hpDss+PtYpPt.....Ppsth.......................................................................phos......VAsQLThLKYNAG..htsPpIQ..h+s...c.....TLYhoGpQ..hKY.RDo+Eul.RA.NRI.lhNsLPp..........G.l...........cpIplT.pp.R..s.hs.VTT.....................ETDV.ASL+p...pLsGps....t...........hp.tp.p.h.s.......puht...............................pGahIccsRa.....saphsPs..LsQSl.GGPEsFYMaQLGlhuoAchWhTDHLLh..sGulFsNlh..NN.YDKFp...o.........................PtDS.pLP.RVRT+lR-YV..pNDVYlNNLQANYFtcLG...N.GFYGQVYGGYLETMauGsGuElLYRP.lDusWAhGlDsN.YVK.QRDW...csM.M+F..............T.DYSs..........................hT..........G...alTA...Y.WsPs.....hhpsVLhKhSVGQYLAtDKGuTl-luKRFDSGVsVGsaAslo...sl..St--..Y.GE.Gs.F.o..KGhYlSlPhDLho.sPsRsRAsluWoPLTRDGGQ.LuR.KapLYsMTu-...........................................................................................	0	24	69	97
+5911	PF06083	IL17		Interleukin-17	Finn RD	anon	Pfam-B_9152 (release 9.0)	Family	IL-17 is a potent proinflammatory cytokine produced by  activated memory T cells [1]. The IL-17 family is thought to represent a distinct signaling system that  appears to have been highly conserved across vertebrate evolution [1].	21.00	21.00	21.70	22.70	20.90	20.30	hmmbuild  --amino -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.09	0.72	-3.92	20	312	2009-01-15 18:05:59	2003-05-28 16:46:01	6	4	67	10	176	271	0	81.80	39	48.52	CHANGED	pRSlS..PWsYpls.......cDssRYPphlsEAcCLCpGClsup.GcEshsh.sSVPlhppllVLRRp............spssstuachchhpVsVGCTC.Vh	......pRSlSPWsY.pls.......pDs.sRaPp.ls-ApCh.CpG..C..l.......s....s......Gp...c.s..tsh..sSlPlhpphhVLRRp.............spssthsachchhtVsVGCTC.V................	0	39	51	81
+5912	PF06084	Cytomega_TRL10		Cytomegalovirus TRL10 protein	Moxon SJ	anon	Pfam-B_8875 (release 9.0)	Family	This family consists of several Cytomegalovirus TRL10 proteins. TRL10 represents a structural component of the virus particle and like the other HCMV envelope glycoproteins, is present in a disulfide-linked complex [1]. 	20.20	20.20	21.20	260.60	19.20	19.20	hmmbuild  --amino -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.96	0.71	-4.41	5	22	2009-09-11 05:08:22	2003-05-28 16:48:09	6	1	6	0	0	21	0	149.10	91	87.75	CHANGED	VCAETTVATNCLVKTENTHLTCKCSPN.......sTSsTGNGSKCHAhCKC.RVTEP...ITMLGAYSAWGAGSFVATLIVLLVVFFVIYAREEEKNN.TGTEVDQCLAYRSLTRKKLEQHAAKKQNIYERIPYRPSRQ.KDNSPLIEPTGTDDEEDEDDsV	.VCAEsTVsTNCLVKoENTHLTCKCsPN.......soSNTsNGSKCHAMCKC.RVTEP...ITMLGAYSAWGAGSFVATLIVLLVVFFVIYAREEEKNN.TGTEVDQCLAYRSLTRKKLEQHAAKKQNIYERIPYRPSRQ.pDNSPLIEPTGTDDEEDEDDDV	1	0	0	0
+5913	PF06085	Rz1		Lipoprotein Rz1 precursor	Moxon SJ	anon	Pfam-B_8925 (release 9.0)	Family	This family consists of several bacteria and phage lipoprotein Rz1 precursors. Rz1 is a proline-rich lipoprotein from bacteriophage lambda which is known to have fusogenic properties. Rz1-induced liposome fusion is thought to be mediated primarily by the generation of local perturbation in the bilayer lipid membrane and to a lesser extent by electrostatic forces [1]. This family Rz1 and the Rz protein Rz (Pfam:PF03245) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway [2].	27.90	27.90	28.50	32.30	26.60	27.80	hmmbuild  --amino -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.23	0.72	-4.54	7	97	2009-01-15 18:05:59	2003-05-28 17:12:01	6	2	60	0	3	60	0	40.80	57	61.59	CHANGED	CsSpPss...C...lKPPsPPAWhMpPssDhpp.LNtIhSsScpp	...........CtSsPPV......C...scPPsPPAWhMpPssDhQp.LNuIISsSEst...	0	2	2	3
+5914	PF06086	Pox_A30L_A26L		Orthopoxvirus A26L/A30L protein	Moxon SJ	anon	Pfam-B_8938 (release 9.0)	Family	This family consists of several Orthopoxvirus A26L and A30L proteins. The Vaccinia A30L gene is regulated by a late promoter and encodes a protein of approximately 9 kDa. It is thought that the A30L protein is needed for vaccinia virus morphogenesis, specifically the association of the dense viroplasm with viral membranes [1].	21.00	21.00	21.00	22.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.75	0.70	-4.88	3	96	2009-01-15 18:05:59	2003-05-28 17:20:21	7	2	32	0	0	88	0	208.20	60	42.94	CHANGED	MANIINLWNGIVPTVQDVNVASITAFKSMIDETWDKKIEANTCISRKHRNIIHEVIRDFMKAYPKMDENRKSPLGAPMQWLTQYYILKNEYYKTMLAYDNGSLNTKFKTLNIYMITNVGQYILYIVFCIISGKNHDGTPYIYDSEITSNDKNLINDRIKYACKQILHGQLTMALRIRNKFMFIGSPMYLWFNVNGSHVYHEIYDGNVGFHNKEIGRLLYA	...........MANIINLWN...GI.VPhVQDVNVASITAFKSMIDETWDKKIEANTCISRKHRNIIHEVIRDFMKAYP.KM.DEN.........+KSP.LGAPMQWLTQYYILKNEYaKTMLAYDN.....G...SL.NT....KFKTL.NI.Y......M..ITNVGQYILYIV.FCIIS.GK.NHDGTPY...I...YD...SE.ITSN.DKNLIN-RIKYACKQILHGQLThALRIRNKFMFIGSPMYLWFNVNGSpVYH-IYDtNsGFHN+EIGRLLYA........................................	1	0	0	0
+5915	PF06087	Tyr-DNA_phospho		Tyrosyl-DNA phosphodiesterase	Finn RD	anon	Pfam-B_8155 (release 9.0)	Family	Covalent intermediates between topoisomerase I and DNA  can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between  topoisomerase I and DNA [1].	22.00	22.00	23.00	22.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.78	0.70	-5.86	27	520	2012-10-02 13:01:53	2003-05-29 09:34:23	7	27	273	43	378	517	1	347.80	22	66.87	CHANGED	Phplhhoslhshpsp.......tsssslsLc-lLus...plppsh.a....sFhhDlsaLlsphs.phhp...plhhlpG...ppt.phhphttt.....th.NlphltsthstsF...GsHHoKMhlhhac-s....h...+lVl.osNhh.tDWs.....hsQshWhSshl........spsssst.........stscF+p-LhpYLppYt......tsl....hpplccaDFSsl...sstLlsSsPGpap.........ph..p..aGaspLtplLpcpss.s......tpspphsl.lsQsSSIGolsss.t.ahpsphhssLhhss...............................tt.ppppsphpllaPoscpl+sShs.GasuGuslha+hp....p+ppp.hl+..shhp+Wtup............sptRspshPHlKsYh+hs..........pphpslpWhllTSANLSpsAWGs......htptssphplpuaEhGVLh......Ppths..................h.shshpts..t.....................hth.hPac.lPhpsYs	............................................................................................................p..slplp.-llt.....l..sh......sahhDhtalhtth....th..h.............lhh.lh..s.........t...t.t..th..t.......................h..plphh.s.h......h...........ushHoKhhllh....htpt..........h...+lll.ouNhh........DWtp..............hpps..........lahpsh...Phh.............tttt................................p.stFpt...cL.htaL.tht........t.h.................hp.l.p.p.h.Dauts...pshhltSsPGhat.....................................p......hGhhtLtphlpphs............................p.....h..l.......hQh...SSlGs.....h............tthhp..sh..............................................................................hpllaPo.pplpp.Sht..G...h.....u...u.s.s.l...........hp..........p.............t.......hlc.......h........h..t.................................................ttRptsh..s.HhK.....hhhths.............................................t...pph.sWhhls..SuNLSpsAW.Gt................................p.ttsph.lpsaEhGVlh........Pt.ht......................................................................................................................h.hPh..hs.............................................................................	0	116	204	316
+5916	PF06088	TLP-20		Nucleopolyhedrovirus telokin-like protein-20 (TLP20)	Moxon SJ	anon	Pfam-B_7657 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus telokin-like protein-20 (TLP20) sequences. The function of this family is unknown but TLP20 is known to shares some antigenic similarities to the smooth muscle protein telokin although the amino acid sequence shows no homologies to telokin [1].	23.50	23.50	23.60	26.50	22.30	23.40	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.04	0.71	-4.58	21	50	2009-01-15 18:05:59	2003-05-29 09:38:37	6	1	47	1	0	53	0	192.40	31	97.19	CHANGED	MAossssTsD.IsVpsplsc-.tccslLsFhlc-EY+LpKhulGAaslpllsop.LssLtpstp..sslssG-YsllaNhsps.spplsslLhslKssslKKusslF+lhhhs................................................ophhhsuss............sppsspsps---s..................sss-shshsts................ssssssK+QKLDcptps	......MAossssTsD.IuVaspl-cE...tscs..lLoFlVc-EYHLKKLuVGAYslsIl-oph.LssLtp.ptp......ssluCGsYllhaNhscp......sstlNsILFNh+.sshLKKusslF+lhahs.............................................................................................tptpsphhtss.s...........sppsspsps---s.......................psss-ssshsts.........................t.stssssK+QKlDcs......................................................................................	0	0	0	0
+5917	PF06089	Asparaginase_II		L-asparaginase II	Moxon SJ	anon	Pfam-B_7673 (release 9.0)	Family	This family consists of several bacterial L-asparaginase II proteins.  L-asparaginase (EC:3.5.1.1) catalyses the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source [1].	25.00	25.00	34.20	34.10	24.50	17.90	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.82	0.70	-5.75	87	514	2009-01-15 18:05:59	2003-05-29 09:45:46	7	4	476	0	211	516	948	313.30	37	94.11	CHANGED	hlclhRGu...................llEShHpGpsVVsDscGp......llhthGsssps.sasRSuhKPhQALsllpoGAspth.........................................slsscc.LALsCASHsGpshHsctstshLtchGLs-ssL......pCuschPhst.st.thhtsstpPstlppNCSGKHAGhLssspthGhshcsYlpscHPlQptltpslp-lsuhss..sph..uhDGCusPsaAhsLpslApuaAphAsu...t.t...s.t.pttsht+lhcAMttaPphVAGpGRhsTpLMcshsGplluKsGAEGVhssul..........sstGlGlAlKlpDG.usRAttssssplLtplsh..........l....sss.hstltphhtsslhst.pGh.sGpl+ss	.................VclhRGs...................hlEShHpGpssVlDs.cGp......llhshGDscps.sasRSuhKPhQALsllco....Gsspth.........................................shssp-LAlsCASHsGE.tHlptstshLtcs..G.....LspssL......pCsschPhpt.sh...thhps.stp...PoslppNCSGKHAGhLAs.stt...........t...........G...........h......s......h...............csYlp.sHPlQ....ptltpsltclsGhsh..sth...GhDGCusPsaAlsLpsLA+uaAphAsu...........t..s........s.t.tttshpRlhcAMtsaPthVAGs.sRhsTtLMctssGtlluKsGAEGVhshul..............sc...G...hGlAlKlpDG..u.sRAttsssstlLpp.Lsh..........h...s.s...t.ttLtpht..p..s.....hhst....tGh.lGplp.s................................................	0	69	144	187
+5918	PF06090	Ins_P5_2-kin	DUF941; 	Inositol-pentakisphosphate 2-kinase	Finn RD	anon	Pfam-B_9098 (release 9.0)	Family	This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase).\	 This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.	22.70	22.70	22.80	23.30	21.70	21.30	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.34	0.70	-5.39	38	330	2009-09-11 15:15:53	2003-05-29 09:47:06	7	11	270	17	238	346	0	342.40	19	82.54	CHANGED	YhuEGsA...Nllhphssss..............................hht+lLRlcKhtts................................ttpppchhcahc..phl+..PLhu....p.lsstplVtls..pphlppl..spplp.........................Rst.R.th...hlssscshuLLlsDlsshst....................................................sslslEIKPKWha...............................p....hpsphCRhCshpthK..................t.tthsptppaCPL...DLh.....usshpclhpAlcs.hsp......spssh+h.htt..........................................................lschLhp...............................................sslLp+LhphQc........................................................ts.pthshpth.shspphtluMTh+DCohhIphp.pt............................................h.hpsplhDLDhK..shpKhppah.ch-pcL	...........................................................................................................................................ahuEGssNllh...thtt..t.......................................................hlLRhhKh..s................................................p..pahp....phhp....hhs..................phlhs..p..lltls......hphlptl..st.lt................................R...+hth..........hs.htpshuhhlsshs..hs...............................................................................................................................................tsshslElK..PKhhh........................................................................................t..t.hptphCRhChh...phhK......................tt..tt...hpp..ppaCPL-Lh.....................uss.hpchhtAlpthhtp.......................spssh+h..tt..............................................................................................hthltphLhp..............................................................................................................................................................................................sslLtcLhp.h.Qt.......................................................................................................................................................................................................t...t.p..ths.h.tt...p..h......pp..hhluhTh+DColhlphp.tt..............................................................................................................................................hpsplhDLDhK..shtph.hah.ph-tp......................................................................................................................	0	82	128	193
+5920	PF06092	DUF943		Enterobacterial putative membrane protein (DUF943)	Moxon SJ	anon	Pfam-B_7843 (release 9.0)	Family	This family consists of several hypothetical putative membrane proteins from Escherichia coli, Yersinia pestis and Salmonella typhi.	25.00	25.00	25.10	28.50	23.20	24.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.11	0.71	-4.93	16	442	2009-01-15 18:05:59	2003-05-29 09:58:29	7	2	256	0	34	201	0	148.80	46	96.19	CHANGED	MKp+pptllh...ullLhuslh..YhhW.thRPVEI................lsVHpcss......stIlV+sFPlTD+GKIsWWhcNKshLKpKYsIPcss.cGhaolhhWDFG-GYc...........cpupsDhhCF-DhK.opcNCI-K.Nhlhslcphp.ssphhFshssspY.hp.........csGclsK..htp-	.................................MKtc.pKllh...sLhLlssl....Y.hW.phRPVpI................lhsapDss.....sshllVcchPhTDpsKINWaLcppsclKspaslPcsu.csaasI...DhGsGap...........EtshpDLhCFsshK.os-NCIsK.NhLMsIpch..cNshha.hh....DtspYQLs.........ppsKIp+shp.s............................	0	5	16	23
+5921	PF06093	Spt4		Spt4/RpoE2 zinc finger	Moxon SJ, Kerrison ND, Finn RD, Bateman A	anon	Pfam-B_7906 (release 9.0) & COG2093	Domain	This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2 [2]. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [1].  RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in [3]. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.	25.00	25.00	27.10	30.20	24.40	23.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.85	0.72	-4.10	37	482	2012-10-03 10:42:43	2003-05-29 10:20:38	8	1	446	10	332	435	72	70.90	37	68.11	CHANGED	hRAChhCpllpohspF..pGCsNC..hhtht.ts.pplt-sTSpsFcGllulhcPpc.SWlA+a.c.lsphhPGhYAlpVs	...........RAChhCpllp..ohsp....F.....p.....GCsNC..hh.t.....ts.t.....s.csTSssFcGllsl..hcPpc.SWVA+a.p....l....sthhsGhYAlpVp..............	0	105	189	271
+5922	PF06094	AIG2		AIG2-like family	Finn RD	anon	Pfam-B_9771 (release 9.0)	Family	AIG2 is an Arabidopsis proteins that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2 [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.73	0.72	-3.52	90	2098	2012-10-02 16:39:48	2003-05-29 10:21:23	7	27	1701	10	779	2120	898	101.30	28	64.81	CHANGED	lFVY...GTLpps.psppthlt.........tsphhspsspht.......hhhhthtsYPsll............ssst................................tVpGp.lapl...sp....pt..LptLDphEt.......pss.hYcRtplplt.............hssstt............pAalYhhp	..................................................................lFVY...GoL..ppt...pss.p.phht....................ssph.h.u..p.h..t..hht..........h..h.h..h..s...h.s.t..Y...P..uhls.......................sss........................................................pVpGE..V..Y.p.l.......ss..............sp......LspLDthcs.................psstYpR.p..h.lp.s.........................................hs.......................pAahYlh...........................................................................	0	261	470	649
+5924	PF06096	Baculo_8kDa	Baculo_8Kda; 	Baculoviridae 8.2 KDa protein	Finn RD	anon	Pfam-B_8370 (release 9.0)	Family	Family of proteins from various Baculoviruses with undetermined function.	25.00	25.00	36.30	35.80	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.29	0.72	-4.09	15	32	2009-01-15 18:05:59	2003-05-29 10:31:12	6	2	30	0	0	25	0	64.50	44	78.56	CHANGED	ssYslppFYNssR+PLKsTTLHsGNIspssYEsVhhhR..+LhC+Esh..Puc+-hpFps.+saNKEN	......s.slppFYNssRpsLKsTTLHDGNlstpsYcsVh.sR...+LhCpEsh..suc+-hKhpp.psaNKEN...........................	0	0	0	0
+5925	PF06097	DUF945		Bacterial protein of unknown function (DUF945)	Moxon SJ	anon	Pfam-B_9171 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	22.40	22.40	22.50	24.10	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	460	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.37	0.70	-5.71	50	1334	2009-09-11 15:55:27	2003-05-29 11:00:00	6	4	964	0	145	797	18	449.70	33	95.70	CHANGED	MKK...hhhGlllulsslhsuusaasGpphEsphpptlsphNt.........sssl..plphhsacRGhFSSpsphplpssssthpt.............shplshssplpHGPhshsp...lpphphhsthh.sp.......sthhp.hhthhtspsPhphssplsasGssssslslsshsh....ptssssls...auGsphphshs.pshpphshpsshsslplsh...........sttplplsslphs.sstptsphs......hhlGspshplcplslssp...............................spphhplpshsht.psphsp........ss...splsuphshslsslphssp.slGssplshplsplDupuhpphhphYpspst..................s...hpptthpplhsslstLLpssPplslssLohcs.spGchshsls..lsLsss..sptttts.......tplhp..shphssphslstshlschht.......................................ph.t..ts.........................t.uppplpthsshhhh.plhs.cssslpsshphssGplsl.NGpch...Pltph	..........................................................MpK....sAsGVIlALull..WsG.GsWYT.GpplE.splpch....lpphNtth+.........hst.psslploYpNacRG....h..FoSphQhhl..p..sut.s..lc..............................sGQpllhspsVcHGPhPlst...Lt+hN.....llPuhAuhpspL.........sNN-hspsLF.ths..K.s.cs.Phphss..Rh.u....a..u.G.ss.so........slslt..PhpY......pptstKlu.....F.usup.hphsuD...pshp.s...l...s.lpGcs.pshhlshs....................................ptsplohpslphD.upuphspht.......hhlG.pp.chplpp.hsIssc...............................Gcchs..l-uhp..hpscoch..sp...........Dt....ctlNspLsYpLs..s..Lph.....p.........s....p.....p....L......GS....Gcl....oLtssplDupA...h+QF.ppYsttspt.h....................tsthups..hhQpt.s....sp.t.......hhstLPhLhcucPslslsPluWKN..upG.E......shNLs..l.ltDP.....upsptss...............sp.hc.....lKoLshcl..plPh.shsoEhhpQhs..............................................................................h..EGh.pt-pAp................................+hAcpQlp.u...h...shGQM..hpLhT..l...p..sN..slshp.L.......pYss..Gplsh.NGQcM...s.E-F...................................................................................................	0	32	63	112
+5926	PF06098	Radial_spoke_3		Radial spoke protein 3	Moxon SJ	anon	Pfam-B_9453 (release 9.0)	Family	This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organisms from protists to humans. They are centred by precisely organised, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation [1].	23.80	23.80	23.80	24.10	22.50	23.70	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.73	0.70	-5.41	14	179	2009-01-15 18:05:59	2003-05-29 11:14:06	6	7	117	0	124	177	8	265.80	39	61.68	CHANGED	hsY........uNIMaDRRVhRGNTYutp...h.up.-.........pppppuppcuhs+K+t+phhss+.........oPsss-GRcphsVQTE.YLEELpD+l...Es-h-sQTDsaL-RPsoPhaVPtKoGtDstTQI..-.....GELFDFDhEVcPIL-VLVGKTlEQALlEVhcEEELtplRppQcpa-phRsAELsEsQRLEtpE+RppcEKERRhpQc+pthcc-+EspcKlsARsFApsYLu-llssVhssLcspGaahD.lcp-lEpsFhPWLhpEVtppltpp....h.u+slLDplIc-lsp.ph.thhptpp	.........................................................................................................htNlMaD+RVhRGsTau.....h.....s..p...p.h.....................ppp.pptp++shs+..Kptpp...h...p.p.........TP.PlcGRpHhslQTE.hY..LE..ElsD+h...Eh-h..-sQTD.sFL.D+PsTPh........FlP.........sKoGhDsuTQI...-.....G-.LFDFD.hEVc.PlLEVLVGKTlEQuLlEVhEEEELssL+tpQptacphRssELsEsQRLEtp.E+Rpp-EKERRhpQphphhcpcpEsppKlsApshAptY.lusLlssVhssLc.spGaFhDslcc..-lEhsFhPWLhp-Vtpphppt....hhuRp....lL.......-.llpplhppp........t................................................	0	65	76	101
+5927	PF06099	Phenol_hyd_sub		Phenol hydroxylase subunit	Moxon SJ	anon	Pfam-B_10062 (release 9.0)	Family	This family consists of several bacterial phenol hydroxylase subunit proteins which are part of a multicomponent phenol hydroxylase. Some bacteria can utilise phenol or some of its methylated derivatives as their sole source of carbon and energy. The first step in this process is the conversion of phenol into catechol. Catechol is then further metabolised via the meta-cleavage pathway into TCA cycle intermediates [1]. 	25.00	25.00	32.80	32.30	17.90	15.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.70	0.72	-4.14	23	83	2009-01-15 18:05:59	2003-05-29 11:20:04	6	1	69	0	24	79	5	58.60	42	70.33	CHANGED	pstP..sh-hp.p+YVRVpucpssuFVEF-FuI.GpPELhVELlLPpsAFctFCtsNpVhcLss	......p..s..h-.h.p+aVRVpucpsssFVEF-FuI.GcPELhVELlLPpsAFcpFCptppVhphs........	0	1	13	22
+5928	PF06100	Strep_67kDa_ant		Streptococcal 67 kDa myosin-cross-reactive antigen like family 	Finn RD	anon	Pfam-B_9995 (release 9.0)	Family	Members of this family are thought to have structural features in  common with the beta chain of the class II antigens, as well as myosin,  and may play an important role in the pathogenesis[1].	23.00	23.00	23.00	23.00	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.63	0.70	-6.15	8	1128	2012-10-10 17:06:42	2003-05-29 11:20:18	6	6	924	0	207	793	40	447.70	47	85.31	CHANGED	-sKSAYlIGoGLAuLAAAsFLIRDGQMsGc+IHILEELslsGGSLDGhphschGYVsRGGREM.ENHFECLWDLFRSIPSLEhsssSVLDEFYWLNK-DPNaSpCRlIcKpGpRlDsDGcFTLopKuhKEIhcLhhTsEEcLsDhpIc-lFS--FFsSNFWlYWpTMFAFEsWHSAhEMRRYlMRFIHHIuGLsDFSALKFTKYNQYESLVLPhlpYLKsHuVsFcYsspVpNIpVDhosuKKlA+pIhhp.+sGcccoIcLT.sDLVFVTNGSITESSTYGssspPAPhTcEL..GGSWpLW+NLApQSs-FG+P-KFCpclPppsWhhSATlTscsc+I.sYIE+ls+RDPhuGKsVTGGIlTlpDSsWLhSaTIsRQPpFKcQscN-lllWlYuLYSDpcGDYIKKPhcECTGpEIspEWLYHLGVPp-cI--LA.pcssNTIPVYMPYIToYFMPRshGDRPhVVPcsSsNLAFIGNFAET....sRDTVFTTEYSVRTAMEAVY	....................p+pAYllGuGlAuLAAAsaLIRDupMtGppIpI..l..E.ch.......s..hs....GGS.h.....D.....G....t...............t...............................s.............p..cGalsRGGREM...-.pHF..EshWDLa+oIPS...LEhs.s.hSVLDEa..hh..l..s....c...c....D...P..s..h.u...p..sR...................ll....c..p..p..G...p...c.....h...s...s..s.uphsLspps.h-lhcLhhss...E...-...cLtshpIp-hF..s.-..-..FFpoNFWhhWpT.MFAFE.WpSAhEh+RYhhRFlaal..sGlschouL+FT+YNQYEShllPhlpaLcspGVpFpass....pVpslp..h..c..h..s...s..s.....p......K......l.....A.p....p...I.hhp....p...s.......G.........p...p..............c...pIpLs.sD..L..VFlTNGSlTEuoohG.Dp.so.......P.....A.....s...............s......p..-h.....uuuWpLW+plAp.....p..s......s..p..FGpP-hFsp.....shscpsW..hShThTs..p...s.p.p.l.h.shI.cplsppcP...hsG...p.hsTGGIlThpDS..sWhhShslsRQPpF+sQs.c.sphssWhYuLascp.Gsal+Kshh-CTGpEIhpEhLYHL.......Gl....s.......p.......p...p......h......cclu..t.......p.tssslPshMPYITuhFMsRshGDRP.VlPcsShNLAFlGpFsEo.....cDsVFTsEYSVRTAM.AVY............................................................	0	53	115	164
+5929	PF06101	DUF946		Plant protein of unknown function (DUF946)	Moxon SJ	anon	Pfam-B_10066 (release 9.0)	Family	This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	19.80	19.80	20.00	19.80	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	536	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.84	0.70	-6.51	15	441	2009-01-15 18:05:59	2003-05-29 11:22:46	6	38	192	0	316	436	14	234.70	18	27.46	CHANGED	s.spsFsLPusLPsWPpGpG.FAsGpIsL.GcLEVspl....osFp+VWsstputscstGsTFacPs.ulPcGFasLGaYsQPNs+PLpGaVLVA+Dluus................ssL+pPlDYTLVhsossht.spps.........sGYFWLP.PP-GY+AlGhlVTssspKPsL..DcVRCVRuDLT-pCEspshI..hs...ssu............hslassRPscRGhtupGVtVGTFhCpsts.ssc...sssIuCLKNlcss.LpuMPNlcQIcALIcpYuPhlYFHPcEpYLPSSVsWFFpNGALLa+KGcps...s.PI-ssGSNLPpGGsNDG..pYWlDLPsD-ps.+EpVK+GsLcSuclYVHVKPshGGTFTDIsMWlFhPFNGPAplKluhh.slsLu+IGEHVGDWEHFTLRISNFoGELWplYFSQHSGGpWVDAsDLEFhp........suNKPVVYSS+HGHASFP+PGhaLQGss..GlGIRNDsA+SchhlDooh+YcIVAAEYLGsulV..EPsWLpYMRcWGPplsYsscsElcplhphLPh.hLRhsh-sllpplPhELhGEEGPTGPKEKsNWpGDE	............................................................................................................................h.h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hGpHlGDWEH.hlRh........u................hahSt..H..t...t.Gt..h....h......t..h....p....h.............................+shhasu.tsHu.as..G.......................................................................................................................................................................................................................................................................................................................	2	86	186	267
+5930	PF06102	DUF947		Domain of unknown function (DUF947)	Finn RD	anon	Pfam-B_9959 (release 9.0)	Family	Family of eukaryotic proteins with unknown function.	23.00	23.00	24.60	24.40	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.33	0.71	-4.43	30	317	2009-01-15 18:05:59	2003-05-29 11:27:36	7	9	285	0	227	311	3	168.00	32	54.68	CHANGED	++psK+uPhEhSSK+.VsphRplhts..........p+s..hhRDPRF-....shuGp.............hs.shh++sYsFL.-DhRppElpclccpLccsK.....ss.......................cE+-cL+pplpshcschcshpp.+cpEpcllp-a++pE+-tlp.pGKp..PaaL..KKS.....-h+Khlhtc..Kacph..............cs+plcK.....hlE++RKKhsuKE+K	..................................+tsKctPhEhSoK+...Vsp..hRplhts............ppp.....hhRDPRFD.........shsGp.............hs..p...h.hcKsYsFL.s-h.RppEhpp...L.+cpL+cp+.........ss...........................................cc+cclcptlpphcsphpspcp.+cpcpclhpch++cc+ct..hc..pGKp..PaaLKKS..........Eh++hhLtp....+acph..............p.stpl-+hl-++RKKpsuK-++...........................	1	78	128	189
+5931	PF06103	DUF948		Bacterial protein of unknown function (DUF948)	Moxon SJ	anon	Pfam-B_10104 (release 9.0)	Family	This family consists of bacterial sequences several of which are thought to be general stress proteins.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.80	0.72	-4.12	42	1305	2009-01-15 18:05:59	2003-05-29 11:30:03	6	7	1253	0	178	574	36	89.90	36	61.21	CHANGED	IuslIhAlAFllLVlalhhsLtpl....pps...lppsspTlpslppplssltppospLLsKsNpLh-DlstKspslsPlhpAluDlupSVpcLNsu	....................lAulIsAlAFllLllall....hsLhpl..................p+s.......lDcsscTlc.......sls.......spV.......sslh...ccoscLLsKsNtLh...-D....lss.....KlsslsslhsAVsslupSVpsLNs....................................	0	49	111	147
+5933	PF06105	Aph-1		Aph-1 protein	Moxon SJ	anon	Pfam-B_7927 (release 9.0)	Family	This family consists of several eukaryotic Aph-1 proteins.Gamma-secretase catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. It is thought that the presenilin heterodimer comprises the catalytic site and that a highly glycosylated form of nicastrin associates with it. Aph-1 and Pen-2, two membrane proteins genetically linked to gamma-secretase, associate directly with presenilin and nicastrin in the active protease complex. Co-expression of all four proteins leads to marked increases in presenilin heterodimers, full glycosylation of nicastrin, and enhanced gamma-secretase activity [1].	25.00	25.00	26.90	26.00	20.50	23.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.64	0.70	-5.12	14	233	2009-09-11 12:57:32	2003-05-29 11:43:55	7	3	130	0	130	218	1	207.00	40	91.12	CHANGED	TlssFFGCsFlAFGPulALFhhTIApDPlRVIlLlAuuFFWLVSLLlSSllWa.lhhslpsp.........lhFGlhhSVlhQEsFRahaa+LL+...............Ks-cGLpul......scpsphs...................................................................hsp+hlAYVu.GLGaGlhSGsFuhlNlLuDuhGPGTlGlcu...........sSphaFlsSAhhoLshlLLHTFWuVlaFsuC-pppahplshV.....VsoHLhlSsLTLLN..shapsoLlssYhlhllhulhAahssGGsltsh........p+hlssc	....................hhhhaGCshlAFGPshuLFhholAtcPl+.lIhLluuu...FFWLlSLLluSllWh.hhh.lpsp............lhh...uhhhSVhhQEhFRh.haa+ll+.............................Ksp......cGLt.sl.....stp.t.p..s..........................................................................shc.hAYVu.GLGFGlhS.....ulF.shl.NlL.....ucuhG..PGshGl..cu...............ss..aFLsSAhhohsllLLHsFWullhFsuh....-c...pp.....a.........htlhhV..........lhsHLhsShhThl.N......hhtssll..s.ahlhl.huhhAhhhsGushtsh..........................	0	44	63	93
+5934	PF06106	DUF950		Staphylococcus protein of unknown function (DUF950)	Moxon SJ	anon	Pfam-B_8992 (release 9.0)	Family	This family consists of several hypothetical proteins from different Staphylococcus species. The function of this family is unknown.	25.00	25.00	42.70	42.20	22.20	18.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.40	0.72	-3.99	3	163	2009-01-15 18:05:59	2003-05-29 11:48:11	6	1	123	1	4	53	0	108.80	74	96.00	CHANGED	MTLoQQLKpYITcLFQLs+sETWcCEulEElAEDILPE+YIcsSPLuHKILpTaTYYNDELHElSIYPFLhYhsKQLIAIGYLD.NFDMDFLYLsDT+psIIDERYLLpcGG	...KThTQELKQYIT+LFQLSNNEsWECEALEEAAENI.LPERFINcSPLsHLTLETYTYYNDELHELSIYPFLMYANNQLISlGYLD.HFDMDFLYLTDTpNsIIDERHLL+pGG....	0	0	0	4
+5935	PF06107	DUF951		Bacterial protein of unknown function (DUF951)	Moxon SJ, Eberhardt R	anon	Pfam-B_8994 (release 9.0)	Family	This family consists of several short hypothetical bacterial proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	25.20	38.50	21.90	24.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.75	0.72	-4.45	42	1332	2009-01-15 18:05:59	2003-05-29 11:51:50	6	4	1322	0	177	594	6	58.70	54	86.09	CHANGED	caplGDIVcMKKsHPCGo.......scWEllRhGADI+IK.ChsCu+hVMlsRtcFEK+lKKllp	.........YplsDlVEMKKsHsCGs.......N+WcIlRhGADI+IK.CpsCsH.VMhsRp-F-+KlKKll.........	0	75	122	152
+5936	PF06108	DUF952		Protein of unknown function (DUF952)	Moxon SJ	anon	Pfam-B_8995 (release 9.0)	Family	This family consists of several hypothetical bacterial and plant proteins of unknown function.	21.60	21.60	23.00	21.80	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.10	0.72	-4.12	102	618	2009-01-15 18:05:59	2003-05-29 11:55:22	7	18	597	3	250	535	577	93.40	34	69.98	CHANGED	IsstspWptuptsGpatsuslDht...-GFIHhSTspQ......lt.pTAs+aFuu...pssLlLL......slDsstLus..s..............L+WEs.................uc.uGtLFP........HLYG......sLslsAVhtsps	...................hstppWptApt..s.Gphtsusl-h.....-GFIH.h.S.o.s.p.Q..................................lt.tsA.s+aFsu.........ps-LlLL......tlDsstLss..s..................l+aEs............................uc.suthFP...............HLYG......sLslsAVlts..s........................	0	78	169	211
+5937	PF06109	HlyE		Haemolysin E (HlyE)	Moxon SJ	anon	Pfam-B_9001 (release 9.0)	Family	This family consists of several enterobacterial haemolysin (HlyE) proteins.Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. HlyE is unrelated to the well characterised pore-forming E. coli hemolysins of the RTX family, haemolysin A (HlyA), and the enterohaemolysin encoded by the plasmid borne ehxA gene of E. coli 0157. However, it is evident that expression of HlyE in the absence of the RTX toxins is sufficient to give a hemolytic phenotype in E. coli. HlyE is a protein of 34 kDa that is expressed during anaerobic growth of E. coli. Anaerobic expression is controlled by the transcription factor, FNR, such that, upon ingestion and entry into the anaerobic mammalian intestine, HlyE is produced and may then contribute to the colonisation of the host [1].	25.00	25.00	26.40	26.20	22.20	21.70	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.91	0.70	-5.41	2	433	2009-01-15 18:05:59	2003-05-29 12:19:47	8	1	323	25	1	123	0	198.90	81	97.36	CHANGED	hsADpTVEsVKsAI-TADtALDLYNKhLDQVIPWpTFs-TlKELSRFKpEYSQuASsLVG-IKoLLMsSQD+YFEATQsVYEWCGVsTQLLsAYl.LFsEYsEKKASAQKsILIKVLDDGIhKLpcAQpSLhsSSQSFNsASGKLlALDSQLsNDFsEKSsYFQuQVDKIRKEAYAGAAAGVVutPFGLIISYSIAAGVVEGKLIPtLKpKLKSVpsFFpoLusTVKpANpDIDtAK.KLpsEIusIG-lKTETETTRFaVDYDDLMLp.Lp-uApKhI.oCNEYQKRHGKKs...l..	..hA-pTVEVVKsAIETADGALDLYNKYLDQVIPWpTFDETIKELSRFKQEYSQAASVLVGsIKsLLMDSQDKYFEATQTVYEWCGVsTQLLuAYIhLFDEYNEKKASAQKDILI+lLDDGlsKLNEAQKSLLsSSQSFNNASGKLLALDSQLTNDFSEKSSa.............................................hpN+LKusQsFFTTLSNTVKQANKDIDAAKLKLTTEIAAIGEIKTETETTRFYVDYDDLMLSLLKtAAKKMINTCNEYQpRHGKKTLhEVP...............	0	1	1	1
+5938	PF06110	DUF953		Eukaryotic protein of unknown function (DUF953)	Moxon SJ	anon	Pfam-B_9087 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	23.10	23.10	23.10	23.50	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.57	0.71	-4.66	6	278	2012-10-03 14:45:55	2003-05-29 12:22:26	6	11	184	2	189	321	7	113.10	28	71.30	CHANGED	sspGa-EFpcslcp..........tppsKslashFoGuKD.ssGcSWCPDCVpAEPVIc-uLKc.sst...-shFlhspVG-RshW+DPsssFRpssphKlTulPTLL+asss.p+..Ls-cpstpssLVEhhFsE	........................................................t......th.phhpt.............pp.s.p..s..l..alhFh.usc.D..ssGp.SWCPDCVpAEPs....lpp.s...h.....pp....hsp.......sshhlhsp.V..G.p+.s.h.W.+.c....s..s.NsFRp...phplpslPTLl+a...p..s.............s....t+.........L.tt.ph.t.phlt.....................................................	0	69	105	157
+5940	PF06112	Herpes_capsid		Gammaherpesvirus capsid protein	Moxon SJ	anon	Pfam-B_9200 (release 9.0)	Family	This family consists of several Gammaherpesvirus capsid proteins. The exact function of this family is unknown.	25.00	25.00	25.80	25.30	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.93	0.71	-4.16	8	23	2009-01-15 18:05:59	2003-05-29 12:31:16	6	1	19	0	1	19	0	156.30	31	92.09	CHANGED	MuptRl+cPhVQGRLEc-aPsc.LlschssLsQsNMoss-Yshs+RsYLVFLIApapYDpYlcpppGIpRK+H.......LpuL+upt...............pssstpsSuhSussuuuouls..................lSuoSso.uhoSuPuSLsuu....................suhosSsusussossssppKK	..Ms.hRl+cPhlQGRLEpDaPspPLlschpsLsQsNhosspYthspRsYLVFLhAQapY-tYlppptGlpR+cH.............lpshRspt.........................t..hsuuhSussuussusss.su..............lusouho..ohoSussSLtuu....................ootssususutsp....t..................................................................	0	0	1	1
+5941	PF06113	BRE		Brain and reproductive organ-expressed protein (BRE)	Moxon SJ	anon	Pfam-B_9280 (release 9.0)	Family	This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induced-NF-kappaB activation upon over expression. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene.Compared to normal cells, immortalised human cell lines uniformly express higher levels of BRE. Peripheral blood monocytes respond to LPS by down-regulating the expression of all the BRE isoforms.It is thought that the function of BRE and its isoforms is to regulate peroxisomal activities [1].	20.70	20.70	24.70	24.50	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.17	0.70	-5.40	2	136	2009-01-15 18:05:59	2003-05-29 12:45:02	7	3	79	0	78	128	0	247.10	45	81.89	CHANGED	MSPEVALpRISP.LpPhlsSVVhNG+VGLDuTNCLRlTDLKoGCTSLTPGPsCDRFKLHIPYAGETLKWDIIFNApYPELPPDFIFGEDA-FLP-PStL.pLspWssuNsECLL.lVKELlQQYHpaQCpRLRESSRLhFEYpoLLE-PpYGcNMEIYAGKKNsWTGEFSARFLLKLPVDFSNIPsYLLK...............................................................................................Vlpaps-hhp+lslh................................F	...........................................................................................................................sDRFpLhIPY..sh-.tl+WDlIFsuphPphsPDFIF.G.......-.D......sc.FhP........-......s......s...t......l..t...s.....LspW...........ssssPcsLL..hllpELl...ppY+paQppRl.t..E..s..s..RL...hFEhpTLlpc.th.s...phcl.hs..shpps....ht.s.hl.lphs...lD..hs...p.l.P....h..h....c......p...sttsh..sh...l.s.sa.pssp.ss..ts.hP..cL.hL..SPp.l-.cuLhusssl+lPsas.s..G.hCLh-Yl.PplpphLpppV.p.slpshchRRcaItAhhshaGp.s.lEhDs..hhpKhohLh...tsFs..FLVH.ltlP.....h..FP+pQPslhhQSs.H................................................................	0	26	38	59
+5942	PF06114	DUF955		Domain of unknown function (DUF955)	Finn RD, Yeats C	anon	ADDA_4938	Family	Family of bacterial and viral proteins with undetermined function. A conserved H-E-X-X-H motif is suggestive of a catalytic active site and shows similarity to Pfam:PF01435.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.45	0.71	-4.39	77	5058	2012-10-03 04:41:15	2003-05-29 13:02:17	8	46	2529	3	1113	3932	890	119.90	16	37.22	CHANGED	scphGlplhhhs............hsttsttthth.t.......................sthlhlssp.hsttcptasluHELuHhhhpspt........................ht.tttpthEhpspth....AsthLlPpphhhtthtpthp.hp...........................lsptaplohphhthclp	..............................................................................h...........................................hh.hh.........................pthI.h.l.s....p....p....h....s....t..s.....p....p....t..a..sluHEL..u.Hhh.hp...ptt.....................................................t..t..t..p..p...p....t....h..E..h.....p....A....s.tF............AsthL..h..P..p........h..h....t....h....h.........t....h.h....th.................................................ltphh.tlohthh..t......................................................................	1	408	776	964
+5943	PF06115	DUF956		Domain of unknown function (DUF956)	Finn RD	anon	Pfam-B_9146 (release 9.0)	Family	Family of bacterial sequences with undetermined function.	25.00	25.00	49.50	49.30	24.70	18.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.50	0.71	-4.49	22	736	2009-01-15 18:05:59	2003-05-29 13:05:51	6	1	702	0	71	320	4	116.70	50	94.62	CHANGED	MsQSlNTKV-LsssGTuYhGhu.cYGKIhlGDcuFEF.YN-pNVccaIQIPWpplshVhAsVh..htGK.hIsR.FpIhTc+tGpFhFuSK-otclL+hlRcalss-+lV+u.olhpsI++tF+	..............MsQSlNppV-LsssuTSahG..lu..chGKhhlGDpuhEF.Ys-pNVccaIQIPWsclstlhAsVh......G+.hIsR.FplhTc.K.GpFhFASKDstplL+hhRcalssD+lV+..o.hhpsIppth.................	0	19	38	53
+5944	PF06116	RinB		Transcriptional activator RinB	Moxon SJ	anon	Pfam-B_9294 (release 9.0)	Family	This family consists of several Staphylococcus aureus bacteriophage RinB proteins and related sequences from their host. The int gene of staphylococcal bacteriophage phi 11 is the only viral gene responsible for the integrative recombination of phi 11. rinA and rinB, are both required to activate expression of the int gene [1].	21.80	21.80	26.00	25.70	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.52	0.72	-4.35	6	399	2009-01-15 18:05:59	2003-05-29 13:10:11	7	2	218	0	7	163	0	48.60	80	91.72	CHANGED	MIK+ILKIhFhluMYEluKYlTcELhlhLTuNDDVE.sPpDFs..sDHhHLN..th.	...........MIKQILRLLFLLAMYELGKYVTEQVYIMMTANDDVE.APSDa.............lhtt.	0	3	3	7
+5945	PF06117	DUF957		Enterobacterial protein of unknown function (DUF957)	Moxon SJ	anon	Pfam-B_9300 (release 9.0)	Family	This family consists of several hypothetical proteins from Escherichia coli, Salmonella typhi, Shigella flexneri and Proteus vulgaris. The function of this family is unknown.	25.00	25.00	27.50	27.00	24.30	23.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.07	0.72	-4.43	5	548	2009-09-11 11:38:57	2003-05-29 13:13:47	6	2	255	0	4	177	0	63.60	84	81.52	CHANGED	MphLTshoALDVLIuWLpDNIDpGS-IIFDNDEDNTDSAuLLPslE+ARpslRcLcuLu..pl+usR	........MKSLTTETALDILIAWLQDNIDCESGIIFDNDEDKTDSAALLPCIEQAREDlRTLRpLQ..LLcQNR.....................	0	0	0	2
+5947	PF06119	NIDO	DUF958; 	Nidogen-like	Yeats C, Myerscough N	anon	Pfam-B_1159 (release 8.0)	Family	This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function [1].	25.00	25.00	25.00	25.60	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.30	0.72	-3.28	27	552	2009-01-15 18:05:59	2003-05-29 13:30:38	9	172	103	0	395	611	5	85.80	32	7.07	CHANGED	sNTFQslLs...oDuspoasl.FhYsp..lpWsssp.....t...t...th.ApsGFsuG-s........sphasl.Pusc..tslhsLhps.oNsGhsGhWhF+l.sst	...............NTFQsVLs......oc.us.....t....oasl.F.Ysp..l.....pWsssp.........t..........t.h.s......A....psG.Fss.Gsu..................sphasl.PuSpp......psl......h....s.....ltps....oN...s...u..hs.GhWhF+lst.t...............................................	0	136	197	302
+5948	PF06120	Phage_HK97_TLTM		Tail length tape measure protein	Moxon SJ	anon	Pfam-B_10088 (release 9.0)	Family	This family consists of the tail length tape measure protein from bacteriophage HK97 and related sequences from Escherichia coli O157:H7.	23.80	23.80	23.80	28.00	23.50	23.70	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.95	0.70	-5.08	2	304	2009-01-15 18:05:59	2003-05-29 14:09:55	6	6	199	0	11	409	2	245.40	55	27.07	CHANGED	QpsLNSsTuVhshlhsGAhG...LlGGlPGllMLGAGAWYshYQpQEQARpSAhpYAsTIEplRsph+pMS.sphosN.upsp.uLctQNphIppQcpKltplpstl..YpthLAssuso.ssahhN......-AspchAs.sstLAVEptRLpQM.sKppphQpllpslpcptl....ppssE.stshpSLh.M......asRL....Npl..uRQuhAs.P.+.....lPt...sppQppAlEKupRpLELStLpG.sKthtphtasAsDLsLsss......RpthlshtlEohRp.pA..Npsp+KGs	...............................QptLNssTuV...GoRLhoGALG......LVGGlPGLl....ML....G..A.u.AW.YTL..Y...QNQEQARESARQYAhTIDEIspKssuMSLPEhoDNEu+TRtALsEQNRLI-EQtS+l+uLpcK...It..s.Yp...h.sLss.su.hss.s.Ghh..l...s...s...tsVT-sLApATcp.LA...VEQsRL....sQMQp..KupS.IQ-lL..A.GLE-RRV.A....LI...RQQA.AEQN...+..sYQShLl.M..N.GQaT.E.....FNRLLGL.GNELLQQ..RQ.GLVNVPLR..................................LPQAT....LD..DKQQoALspoERE.LAL.SRLKGE.tKERsRLGYAADDLGF.VG.-....sYQpARQpYIsNuL-AWRNNps..NKPKu..................................................................................	0	0	1	9
+5949	PF06121	DUF959		Domain of Unknown Function (DUF959) 	Yeats C	anon	Pfam-B_25471 (release 8.0)	Domain	This N-terminal domain is not expressed in the 'Short' isoform of Collagen A [1].	25.00	25.00	27.00	27.00	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.57	0.71	-4.67	3	37	2009-01-15 18:05:59	2003-05-29 14:10:13	9	19	24	0	16	34	0	173.50	48	14.16	CHANGED	LLpCpLsuAcA-ssSLSs.p..sWLWhPpT-sS.sAoolucPQuSoPVQSTE....sTTTHVVPRsGpTEpuTTPASSE.PsEl.....lE-GcQpss.GssssTPTVs.shhssAuSPDh..........sEENIAGVGAEILNVAcGIRSFVQLW.EDoVsscS...ApT.VPDTsl.PhVLAoP..lSSsPQsssTTLW.SSuIPSSPuApTTEAGT...LuuPTpLP	.........LL.CsLsuApAchhsLs......WLW.sppsss.htsslscPpss.sVQsTt....ssTTHVsPps..G.TE.tTss.uSsc.P.E.......Etupt.........oPo.......sAtSPDh..........pEENIAGVGAKILNVAQGIRSFVQLW...cDoss.scS...ApT.sssoss.PhsLPsP......SSsPQpssTTLh.SpshsSSPsspTTEAGT...LssPT..................................	0	1	2	7
+5950	PF06122	TraH		Conjugative relaxosome accessory transposon protein	Moxon SJ, Coggill P	anon	Pfam-B_10166 (release 9.0)	Family	The TraH protein is thought to be a relaxosome accessory component, also necessary for transfer but not for H-pilus synthesis within the conjugative transposon [2] [3].	25.00	25.00	28.50	28.40	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.28	0.70	-5.64	41	471	2009-01-15 18:05:59	2003-05-29 14:14:35	6	3	341	0	63	366	37	338.70	34	76.51	CHANGED	hsshF.sshsh.uNsTsPuuapuQstGaaoGGulhsRssh..cshpLhslshPshpAGCGGIDhFhGuFSFINu-plVphh+sIsuNAs....uaAFpLALpslsPplspshppLpphsptlNphshsSCphApulVsshh..spt..sss.ppphsps...hu..spsuhhsDahsu.pptstsssppss...............hstsssssttpp.hhhstNlsWpulp+sshh...........tsspphtEhlMSlsGTlIh.......sssussh.hst.hssssshlss......LlsGss...t.......hclapCs...ss.....spCl.......s.pshslstt.............pulpsplpphl..............puIhsKlts.c.....ssLos....scpsFl.ss..oslPlhchlphtssh.thshusp.hpphu-hlAh-lhhphLpph	....................MsphF.sph...tuNsTpPusapuQstGh.hsGGSlhsRspl..ps..hpLlShshPshsAG...CGG.IDhahGSFSFINu-Qlhphl+pIhuNAs....GYhFpLALpshsPchpssh-hLQchspplNphshsSCphAQulVsshh......spt....pss.pppssps...lu.......spsshhuD..asuu.pptss.suuppss......................hspAssp..pccthhhshNlhWpALp+sphh................................tuspcLtEhlMoloGollh.................sssuphs.h.ss.hs.ss..ps...hlps....................hhc.GGs.............................sclYpCs..ss..........spCL.......sssssolspt......................................puLpsplpphL.........................suI.sKhss..c.....ssL.ss....pEKuFl.ss..oslP....lhphl..hss.....ususshh.phs-hIuh-hhhpalp-...............................................................................................	0	18	33	50
+5951	PF06123	CreD		Inner membrane protein CreD	Moxon SJ	anon	Pfam-B_10187 (release 9.0)	Family	This family consists of several bacterial CreD or Cet inner membrane proteins. Dominant mutations of the cet gene of Escherichia coli result in tolerance to colicin E2 and increased amounts of an inner membrane protein with an Mr of 42,000. The cet gene is shown to be in the same operon as the phoM gene, which is required in a phoR background for expression of the structural gene for alkaline phosphatase, phoA. Although the Cet protein is not required for phoA expression, it has been suggested that the Cet protein has an enhancing effect on the transcription of phoA [1].	19.70	19.70	20.00	19.80	18.10	19.40	hmmbuild  -o /dev/null HMM SEED	430	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.13	0.70	-5.94	48	880	2009-01-15 18:05:59	2003-05-29 14:19:36	7	2	798	0	101	509	60	380.70	47	94.10	CHANGED	pslhhKhhhluhLhLLLlIPLhhlpslIpERpphpppslscIupShuupQplsGPllslPap.cphpppp....stpthpphpp.....................hhhlLP-pLslsuphpsc.RpRGIYps.VYpupsplpupFshs...t.p.phhstpplh.........hspshLsluloDh+GIpsssplplsG.p.slsh.........pPGs.............thsthsp..Gl+sslsthshpps.........tlsashsLpLpGoppLullPlGcsoplsLpSsWPHPSFsGsaLP..spRplossGFpApWpsothupshsphh..........ttss.sshsttu.............huVshlpPV-tYpps-RAsKYulLFIsLTFhuFFlhEllpphtlHPlQYlLVGLALslFYLLLLSlSEHlGFshAYlluususlhLluhYlsslL+uh+puhsauuhLssLYulLYslLptEDaALLhGSllLFhlLuslMhlTR+lDWYs	...............................................................................s.sLhaKhssLhshhlLLLIPlhhlcplIsERucYRscV.ssIppSoSGsQ+llGPllslPhoEhhpsp-......ppKpsppp+sh....................hhahLPEsLhVcGs.ss.Et.R+hGIYpupVapu-hsl+AcFcls.........ph..p-l.s..t..sslt.........hucPalVluluDsRGIsslps..plsG......p.sL.sl............................EPGs.......................................ultpsspGl......HhP..Lsps.shtpp.............................sLplsh.sLsLsGTuslSlVPsG+sochsLsSNWPHPSFhGsFLP...scRclo..ts....GFpApWpoShh...AsN.hsppa......................sss..pph.sh...shsu......................FoVulhsPsDpYQlo-RAsKYAILhIsLTFhuFFlFEsLosp...RlHPhQYLLVGLuLVh..FYLLLLuLSEHlGFshAallASLhsslh.ulYLpuVL+uh+puhlF...shuLlhL.GlhauL.LpStDsALLlGoslLhlsLuuhMalTRplDWYt..........................................	0	29	52	73
+5952	PF06124	DUF960		Staphylococcal protein of unknown function (DUF960)	Moxon SJ	anon	Pfam-B_10198 (release 9.0)	Family	This family consists of several hypothetical proteins from several species of Staphylococcus. The function of this family is unknown.	25.00	25.00	25.80	25.70	24.10	23.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.94	0.72	-3.74	11	633	2009-09-11 15:24:04	2003-05-29 14:22:46	6	1	565	4	34	211	0	93.80	41	90.95	CHANGED	sRYAShGlVoSLPs-lIDshWhII....DppLKsVhsL-sllpFpLlNspGplol+FSQcpssshlshDhshhasPha..Pp+VallDpss+ET....IlLPcE	.......tRaAShGlsoSLPs-lIDohWhII....Dc.hLKsVhcL-plLpFpL.h..s.s.pG.....p....l...o.h+FSppp.sst..l-....aDasp..a..cspa..Pt+VhVlDpDspET......ILLPEE........	0	8	15	25
+5953	PF06125	DUF961		Bacterial protein of unknown function (DUF961)	Moxon SJ	anon	Pfam-B_10221 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	26.20	26.00	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.18	0.72	-3.84	12	903	2009-01-15 18:05:59	2003-05-29 14:24:23	6	1	354	1	46	274	8	100.40	42	88.16	CHANGED	.hchlVs-hpcTFGsLcFuu.sc.lhtps.sGphs....hpRoYsLhSslQ.uc.I.VolPApAG.KcFs.ptcVcLlNPhlsshuhthhp.G..hssahlcADDlVh	..................hphlV.Dh-pTFGpLcFuu.cc.Vh.ps........tsGssos...hpRoYsLhSssQ.uc.I.VslPAp..ss.K..cF....sYptcVcLlNPhhs.shuhthhp.G.....ssahl+ADDlVh.....................................	0	22	33	35
+5954	PF06126	Herpes_LAMP2		Herpesvirus Latent membrane protein 2	Finn RD	anon	Pfam-B_9147 (release 9.0)	Family	Family of Kaposi's sarcoma-associated herpesvirus (HHV8) latent membrane protein.	20.80	20.80	21.20	139.90	19.90	20.70	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.76	0.70	-6.09	2	12	2009-01-15 18:05:59	2003-05-29 14:30:16	6	1	3	0	0	12	0	457.10	70	99.80	CHANGED	ph+hahWshWhhALlsChhClolh.ClhT....NoI.hhusl.Vhh.LFsohhNhYsQ...Spp.+a.uS..lG...IluCIsht.WshoTpsolohsClhhhulLSllTAhLuLhtphpssKhpl-pGlLChshhhVLIhsMhlph.NsWpps.hFhPl.hhL.l.FlahFATspssslKLsusV.hICuGllhuhPs.hChoHoChushhuhslSsIalGhTGlhhTh++pWhssp+GlhoFLLLQGGVLsT.ThThtlLhIpppp.sN.cGp.hLLhsChhhLaChasWQSFpKASLssGhLaLhhAWopsGsCVpLVhLhssGhTpGlhohlICl.slhSThQulLVhYLY+Ep+lVuhNsh.ppRh.IYT.cps.Htps.......NHLuppl...PPLPsh.h..sRl.SpsTD......RspsopshsplEhQplpp-..pshsYASILssss..spcsSsp.sQSGhS..pVsssushplD...sshQPsD-lYEEVLFPps	....hhhFFWNLWLWALLVCFWCITLV.CVTT....NSIDTMASLLVMCILFVSAINKYTQAISSNNPKWPSSWHLG...IIACIVLKLWNLSTTNSVTYACLITTAILSLVTAFLoLIKHCTACKLQLEHGILhTSTFAVLhTNMLVHMSNTWQSSWIFFPISFTLSLPFLYAFATVKTGNIKLVSSVSFICAGLVMGYPVSCCKTHTCTATAAGLSLSSIYLGFTGIISTLHKSWAPPKRGILTFLLLQGGVLTTQTLTTELLAITSTT.GNIKGHEILLLVCLIFLWCLYVWQSFNKASLVTGhLHLIAAWSHTGGCVQLVMLLPSGLTRGILTMIICISTLFSTLQGLLVFYLYKEKKVVAVNSYRQRRRRIYTRDQNLHHND.......NHLGNNVISPPPLPPFFRQPVRLPSHVTD......RGRGSQPLNEVELQEVNRDPPNVFGYASILVSGAEESREPSPQPDQSGMSILRVDGGSAFRIDTAQAATQPTDDLYEEVLFPRN.............	0	0	0	0
+5955	PF06127	DUF962		Protein of unknown function (DUF962)	Moxon SJ	anon	Pfam-B_10320 (release 9.0)	Family	This family consists of several eukaryotic and prokaryotic proteins of unknown function. The yeast protein Swiss:P25338 has been found to be non-essential for cell growth.	24.00	24.00	24.00	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.21	0.72	-4.09	66	1112	2009-01-15 18:05:59	2003-05-29 14:30:38	6	4	665	0	460	999	358	125.90	25	82.98	CHANGED	apoFt-FaPFYLspHpssssRtLHalGoslllhhlhhs.lhssp......................................................................h...hhllsh.lsGYuFAWlGHFhaEKN+PATFcaPLaSlhuDahMahphlsG+l	......................................................................................................................................................tshtcahshY....hs.Hps.hNh.tlHhlulshll...h...slhhh....lsph.s................................................................................................................................................h.hhsl.u..lhl...lGa..s...h.Qa..l.....GHh.aEtp+PAh.hcs.l...uLhhs.hhlht.lhh..h..............................................	0	141	254	370
+5956	PF06128	Shigella_OspC		Shigella flexneri OspC protein	Moxon SJ	anon	Pfam-B_10333 (release 9.0)	Family	This family consists of the Shigella flexneri specific protein OspC. The function of this family is unknown but it is thought that Osp proteins may be involved in post invasion events related to virulence. Since bacterial pathogens adapt to multiple environments during the course of infecting a host, it has been proposed that Shigella evolved a mechanism to take advantage of a unique intracellular cue, which is mediated through MxiE, to express proteins when the organism reaches the eukaryotic cytosol [1]. 	23.60	23.60	23.60	35.20	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.81	0.70	-4.91	3	72	2009-01-15 18:05:59	2003-05-29 14:34:55	6	1	24	0	2	67	1	245.20	77	66.94	CHANGED	VEISNH.QcK+PLN+KHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQS.FLDsFsEVscEVSRYVHGuKG+pDVPIFNTKDMKLGlGLHLIDFIRKSKDQuFKEFCYsKNlsP.VuLDRIINFVFQsEYHIPRMlST-NFKKlKLR-ISLEEAVcASNYEEINspVTsKKhAlQALaaSIsNpK-DVALYLLSNFcFT+QDVAShc+.......sLY.DlEYLLScHGASsKVLEYFIN+GLVDVNsKFcKsNSGDTMLDNAlKYcNuEMIchLLKaGAh.D++a	.......VEISsH.QcphPLNppHHTVDFGANAYIIDHDSP...YGYMTLTDHFDN......AIPPVFYHEHQS.FLDpFpEVs-EVSRYVHGspGppDVPIFNTKDM+LGlGLaLIDFIRKScDQuF+EFCYsKNlsP.VsLDRIINFVFQ.EYHIPRMlST-NFKKl+lR-ISLE-AlpASNYEEINppVTsKKhAhQALhhSl..sNtKtDhALYlLSpFphT+QDVhphc+.......pLY.DlEYLLStcsushKVLEYFINpGLVDVNp+FpKsNSGDsMLDNAhK.csucMIchLLK.GAh.sp+a.............................................	0	2	2	2
+5957	PF06129	Chordopox_G3		Chordopoxvirus G3 protein	Moxon SJ	anon	Pfam-B_10417 (release 9.0)	Family	This family consists of several Chordopoxvirus specific G3 proteins. The function of this family is unknown.	22.30	22.30	22.40	22.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.26	0.72	-3.91	12	50	2009-01-15 18:05:59	2003-05-29 14:37:30	7	1	42	0	0	33	2	107.80	52	98.97	CHANGED	usLl.lhFFllFLllsYahsahPTNKhpluVpphs.-ttlhKptssshss.hhsThlFscs-phlssplpshYcupputVslhpsscKhsFpLshccDVRsLLPILLLSK	.u.sLLYLllFllFlsluYYFoYYPTNKLQhAVhEpscENAII+QRN--l..Po.oL-TsIFTcssolsSupIpLYYNSshG+llhuhN.uKK+TFNLhcDsDIRTLLPILLLSK..	0	0	0	0
+5958	PF06130	PduL		Propanediol utilisation protein PduL	Moxon SJ, Bateman A, Finn RD	anon	Pfam-B_10447 (release 9.0)	Domain	This family consists of several bacterial propanediol utilisation protein (PduL) sequences. The exact role of this protein in propanediol utilisation is unknown. Sequences containing this domain usually have two tandem copies (Bateman A, pers. obs.).	25.00	25.00	26.90	30.00	19.20	18.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.26	0.72	-4.16	125	1579	2009-01-15 18:05:59	2003-05-29 14:40:30	7	10	646	\N	291	1010	41	75.90	35	69.09	CHANGED	phsVhlusRHlHhopcDscthhs.............psGphsshcs...sGs+.shhcsVhlhuss+hpsphclsts-ApuhGlp	.........s..slhVupRHIHho.pDsctLhs.............psGphsshch...sGs+.shhcsVhlhss.s+htsphcIsts-ApshGl.....	0	156	224	254
+5959	PF06131	DUF963		Schizosaccharomyces pombe repeat of unknown function (DUF963)	Moxon SJ	anon	Pfam-B_10581 (release 9.0)	Repeat	This family consists of a series of repeated sequences from one hypothetical protein (Swiss:Q96WV6) found in Schizosaccharomyces pombe. The function of this family is unknown.	21.00	21.00	21.30	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.47	0.72	-4.68	8	150	2009-01-15 18:05:59	2003-05-29 14:45:17	6	5	8	0	146	151	2	35.90	79	70.47	CHANGED	ITSSoslNSSTPITSSTslNSSTPIsSSSlLNoSTP	.....ITSSoVLNSSTPITSSTVlNoSTPITSSoVLNSSTP.......	0	144	144	146
+5961	PF06133	DUF964		Protein of unknown function (DUF964)	Moxon SJ	anon	Pfam-B_10600 (release 9.0)	Family	This family consists of several relatively short bacterial and archaeal hypothetical sequences. The function of this family is unknown.	22.10	22.10	22.40	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.31	0.72	-4.03	233	2444	2009-01-15 18:05:59	2003-05-29 14:52:23	6	3	1220	12	316	1032	15	107.70	22	85.69	CHANGED	slhDpAppLsctlppo-EapshcpucptlpsspcupplhpcFpphQpph.pphpphGc..s..ccsppchpphtpplptpshlppahpuppplsplls-lsphIspsls-h	.........sIhDpAppLsctlpps-phpshcpucptl.psspcsp..plhpcapphQpph..pphp.phGc.hs.....ccstpchpphtpplptpsllppahpsppphspllp-lsphItpsls-.................	0	99	196	262
+5962	PF06134	RhaA		L-rhamnose isomerase (RhaA)	Moxon SJ	anon	Pfam-B_10641 (release 9.0)	Family	This family consists of several bacterial L-rhamnose isomerase proteins (EC:5.3.1.14).	19.60	19.60	19.60	19.80	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.41	0.70	-5.57	5	861	2012-10-03 05:58:16	2003-05-29 14:57:12	6	2	844	20	102	524	40	402.70	65	97.99	CHANGED	MslKpsYEpAKpcYppWGIDVEEAL+pLKQlPISIHCWQGDDVsGFElscGELSGGIDVTGNYPGKApTPEELRpDLEKALSLIPGKHRVNLHAIYAETDtEsVERDEIEP+HFENWV+WAKcpGLGLDFNPTLFSHPKAcDGLTLAHPDc-IR-FWI-HCIASRKIuEYFGKELGTPuLTNIWIPDGYKDIPSDRLTPRKRLcESLDcIFuEEIDEpYNlDAVESKLFGIGSESYVVGSHEFYMGYALoNcKLCLLDTGHFHPTEsVSNKISSMLLYoDcLALHVSRPVRWDSDHVVlLDDELREIALEIVRNDALD+VpIGLDFFDASINRIAAWTIGTRNMIKALLaALLpPsucLKcLQEEGDYTcRLAlhEEhKTYPFGAIW-hYCEpMsVPVGE-WLcEVKtYEKEVLLKR	..............................................................................................plEQAaElAKpRaAAlGlDVEcAL+pL-+lPVSMHCWQGDDVsGFEN.P-.GuL.T.G..GIQATGNYPGKARNusELRuDLEpAh.............p.LIPGsKRL.NLHAIYL...E.oD...p.s..VsRDpIcPEHFcsWVEWAKtNpL.GL...D...F...NPoCFSHPh.Su.D.GF...TL...SHsDcpIRQFWI-HCKASRRlSAYFGEpLGTPSVMNIWIPDGMKDI..T.VDRLA.P.R.Q.RL.ls.ALDEVlSE.K.lcPAHpIDAVESKLFGIG...AES..YTV..G..S..NEFYM..GY....A....sS....R......p.s...s.L..CLDAGHFHPTEVISDKISAshLYVPpL.L.LHVSRPVRW.DSD..HV..V..L...LDD...ETQAIAsEIV...R.c.....c.L..h...D.........R...V...H...IG..L..D.FF.DASIN...RIAAWVIGTRNMpKALLRALLEPTspLRcLEssGDY.T.u.RL.AL.LEEpKSLPWpAVW-hYCQRpcsPsGu-WL-sVRsYEKclLSpR.................................................................................................	1	34	68	84
+5963	PF06135	DUF965		Bacterial protein of unknown function (DUF965)	Moxon SJ	anon	Pfam-B_10661 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins. The function of the family is unknown.	25.00	25.00	27.30	39.10	24.40	17.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.63	0.72	-3.93	34	1369	2009-01-15 18:05:59	2003-05-29 15:32:34	7	1	1357	0	173	496	5	78.80	59	90.15	CHANGED	hDcTMpFchscpc.pppl+-lLpsVYpALcEKGYNPINQIVGYLLSGDPAYIspap-ARsLIR+lERDEIlEELV+sYLp	................DcTh+Fc.h.c-sp..cp.clp..-sLpsVYpuLpEK.GYNPINQIVGYLLSGDPAYIPRaNsARN.IR+hERDEIlEELV+hYLc..	0	76	119	147
+5964	PF06136	DUF966		Domain of unknown function (DUF966)	Finn RD	anon	Pfam-B_8637 (release 9.0)	Family	Family of plant proteins with unknown function.	22.40	22.40	22.70	42.50	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.35	0.70	-5.02	15	135	2009-01-15 18:05:59	2003-05-29 15:43:41	8	4	19	0	91	127	0	321.00	29	72.73	CHANGED	VsVVYYLoR.NGp..LEHPHFlEVhluSpsG.......LYLR........DVIsRLssLRG+GMAuhYSWSsKRSYK..NGFVWaDLu-.DDlIhPs...sspEYVLKGS...............Ellcss.p....................s..sp.thps......p...spp.p....ssshsshs++pstsh...........................................uShshsEY+lhKsp-.tt.......tt..huuDASTQT--shptpp.h...................................sspscsspls+p-h.SPssos......tuss-oLEsLh+A-uphhpu.phhppppht..................+h+AoulLMQLISCGuhSsKc.........tpuhthspph+sphspu.hsp...tts................ph....tphphE-KEYFSGSLlE..TKppp........thsuLKRSSSYNs-Rusph	....................VtVVYYLsR.sup..LE.HPHahEVshsu..p.s...........LhLR...................................DVhpRLssLRG+GMsshY......SWSsK...RsYK..NGaVWpDLs-.-DlIhPs....pu.s.EYVLKGS...............Elhptsss..................................................................p.t...pp........t.......t.t........tss.ss...p.t.pptts..............................................................................................................................................................ss.s...tchps..cspt..................hstssuTpTccptpt.t.t.........................................................ttptptsplspcph...ssssss.......tsps....pshc.slhpscs...p.hh.ts.p..p..p...t.........t......................+h+sus.lLh.QLIo.CG.uhuspp..........tshh.h....hp.ph..............................................h....ht.th.cp-hFSGullp.pt..t...........s.L+pSsuhs..h.................................................................................................................................................................................................................................................................................................................	0	17	54	74
+5966	PF06138	Chordopox_E11		Chordopoxvirus E11 protein	Moxon SJ	anon	Pfam-B_10685 (release 9.0)	Family	This family consists of several Chordopoxvirus E11 proteins. The E11 gene of vaccinia virus encodes a 15-kDa polypeptide. Mutations in the E11 gene makes the virus temperature-sensitive due to either the fact that virus infectivity requires a threshold level of active E11 protein or that E11 function is conditionally essential [1]. 	21.00	21.00	22.80	51.10	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.54	0.71	-4.05	8	48	2009-01-15 18:05:59	2003-05-29 16:57:42	7	1	34	0	0	33	0	127.00	59	97.10	CHANGED	MELVNIFLESDsGRVKLth-.ssptCtpp.tsphh+AlchFlslL+KYIcV-cSTFYLVIKDpDIFYFKhDKGplo.l-NEFaTFscsLhFlc.sa..scITGIpFllTDTMslpIhP+sshtVlupSsNp+aY	MELVNIFLETDuGRVKhsIcNs-chCsop.......hIs+FlElLucYI+l-pSpFYLVVKD.KDIFYFKCDRGSISlVsNEFYV.FDEsLLFVc.Da..opVTGVEFIVT-TMPs+IlPKssaAVISsssN+KFY......	1	0	0	0
+5967	PF06139	BphX		BphX-like	Finn RD	anon	Pfam-B_8664 (release 9.0)	Family	Family of bacterial proteins located in the phenyl dioxygenase  (bph) operon. The function of this family is unknown. 	24.70	24.70	24.90	177.70	23.50	24.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.80	0.71	-4.58	7	27	2009-01-15 18:05:59	2003-05-29 16:59:10	7	2	26	0	4	18	1	135.70	63	97.89	CHANGED	MK..........psRsFLlAlGlFYLhNLlGTLPFtshuLhshMYPGVthpsutPhFpLLpDAWhVVGLQLuAIGlVALWGARDPhRYh.AllPVVIsTElVsGlWDhYSlsWu+.AlhFuLsTLllHslWIsWuLhshRuspppt.......t	....MKpuRlFLIAlGlFYlhNLlGTLPFuohGLFuhMYPGV-LcsGsPlFsLLpDAWAVVGLQLGAIGsVALWGARDPhRYh.AVlPVVIATEVVDGLWDFYSIlWSHEAhWFGLsTLlIHslWIsWuLaAWRAhtpp.sh.	0	1	3	4
+5968	PF06140	Ifi-6-16		Interferon-induced 6-16 family 	Finn RD	anon	Pfam-B_9299 (release 9.0)	Family	\N	25.20	25.20	25.20	25.30	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-4.20	27	261	2009-01-15 18:05:59	2003-05-29 17:08:26	8	6	81	1	139	237	0	77.60	48	56.27	CHANGED	AslG.Gsh...AVsAsPllLuAlGFTuuGIAAuSlAApMMSuAAlANGGGVAAGSlVAsLQSsGAAG..LSssusslluusGuslGuhl	.....................hhG.ush...sV...sus....Ph....s....Lu.....AlGFTuuGIAAuSlAApMMSsuAlA.NGGGVuAGSLVAsLQSlGAsG.....luh.s.u...p.h.hlussGushsh..h......................	0	52	68	93
+5969	PF06141	Phage_tail_U		Phage minor tail protein U	Finn RD	anon	Pfam-B_9209 (release 9.0)	Family	Tail fibre component U of bacteriophage.	25.00	25.00	26.90	26.50	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.62	0.71	-4.13	8	798	2009-01-15 18:05:59	2003-05-29 17:25:50	6	2	357	23	15	274	3	127.30	64	99.43	CHANGED	MpKHopIRpAVLsALcpphusssoaFDG+PuFl-.Ep-LPAVAVaLTDApYTGphlDpDsWQAsLHltVFL+AQAPDSELDhWMEp+IaPALp-VsGLssLIsTMsspGYDYQRDDEMAhWuuADLoYpITYsh	........M.KHT-IRAAVL-ALc.cp.....cs.u......ATh.FDGRPulh.........D....EpDhP.AVAVYLT.-ApY.TGEplDs.DTWpApLHIEVFL.A.Qs.PDSELDtW.......ME..S+I...YPAhs...sIPALS..sL..IsoMls..pGY-YRRDD-huhWuSAD.LTYsITYEM............	0	0	3	8
+5971	PF06143	Baculo_11_kDa		Baculovirus 11 kDa family	Finn RD	anon	Pfam-B_9424 (release 9.0)	Family	Family of uncharacterised Baculovirus proteins that are all about 11 kDa in size.	22.20	22.20	22.20	22.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.88	0.72	-4.62	16	47	2009-01-15 18:05:59	2003-05-29 17:40:57	6	1	45	0	0	42	0	85.70	38	88.72	CHANGED	Mppssuplsst.s...............sSll-tDQLsQlVoRNRoFl+DFlLVICuhlVFVhIlLFllLlhsI.psh-h.ptp+.phppshLuNhDh+	...............Mp.pstthhs...s...............sSshstDQLpQlV..sRN+oFl+-FlL.VlCuh.llFVhlllFlhLl..hsI.pshEh.....psp+.phppshLtNhDhR......................	0	0	0	0
+5972	PF06144	DNA_pol3_delta		DNA polymerase III, delta subunit	Finn RD	anon	Pfam-B_9452 (release 9.0)	Family	DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction [1]. The delta subunit is also known as HolA.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.62	0.71	-4.75	24	4182	2012-10-05 12:31:09	2003-05-29 17:51:43	8	10	4065	11	910	3675	1752	168.00	20	49.90	CHANGED	YllhGp-.hLlpcsppplhptshppshp-hshhph-hsps.hp..lhpphpohshFus++llhlp.s.........psthstp.hppLpphlpphsscslLllhus..KLscchc...hhKhLpp...puphlcsps.....ctpplhpalpphspphslplspcuhphLhthhpsshttltpplp+Ltl	........................................................................llhGs-.hL..hpctt.s...t...lh.pt.....h......h......t....p.....s..h......p............-....h.p.....h..h...p..h...-......h......p...p...s.........h..p.............l....h.....s.......p.s.ps.h...s.h...F....u...s..c......+...llllc.s..........................ppt.spp...t...h....c..t....L.h.p....h..h....p....p.........s.....s....s...sl...L...ll..ht...s....+....lsc.ppc......................hhctLp..p.........pu.h..h..l.p...s......t.p...........ct.p.pl....pa.lp......pc.h....p.p.t....s...l.....p.....l.....s.....s.....s.....A.......h.p.......hL....h......p.......t....h.......s.......s.......s....lhtltpplp+Lt...........................................................................................	1	308	602	775
+5973	PF06145	Corona_NS1		Coronavirus nonstructural protein NS1	Finn RD	anon	Pfam-B_9242 (release 9.0)	Family	Bovine coronavirus NS1 encodes a 4.9 kDa protein [1].	25.00	25.00	29.10	29.00	18.20	16.90	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.90	0.72	-7.33	0.72	-4.64	2	37	2009-09-11 06:11:25	2003-05-29 17:53:54	6	2	34	0	0	20	0	28.80	90	77.53	CHANGED	MphKFVFDLLsPDDILHP.NHVp.IIRPI	MpTKFVFDLLAPDDILHPSNHVNLI.IRPI..	0	0	0	0
+5974	PF06146	PsiE		Phosphate-starvation-inducible E	Finn RD	anon	Pfam-B_8639 (release 9.0)	Family	Phosphate-starvation-inducible E (PsiE) expression is under direct positive and negative control by PhoB and cAMP-CRP, respectively [1].  The function of PsiE remains to be determined.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.88	0.72	-3.74	96	1842	2009-01-15 18:05:59	2003-05-29 17:55:37	7	5	1500	0	409	1034	1208	68.20	32	49.00	CHANGED	lsslLhlllhlElhphlhtYhcpp.cl..tlphllhhAlhAlsRtlIl.htsthps..h.....htlussllhLuh	..............thlhhFlhFEhluh.l.l.p.Y.hpss...Hh..PlRahlhIuIoAllRhlI.ls.cc.s.shss.................lhhuuulLlLs.................................	0	88	221	323
+5975	PF06147	DUF968		Protein of unknown function (DUF968)	Finn RD	anon	Pfam-B_9463 (release 9.0)	Family	Family of uncharacterised prophage proteins that  are also found in bacteria and eukaryotes.	30.10	30.10	30.20	30.20	29.80	30.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.32	0.71	-4.41	23	1469	2009-09-11 20:49:19	2003-05-29 18:00:05	6	7	701	0	60	1205	78	190.80	45	67.20	CHANGED	sspcLp.shsppplssh...slptplphsDs+plohtphph.aAltNDl......tphh...PpsshR+hhph.hphhpuh.....-sclshup.s.so...pphtpclh..................chllshsh-s-sPhsahppsthpp...cpalha.ltspsCslCG....+tssDhHHl....IG+Gps+hthctaDhallsLCRcHHpElHp.sspsF-cKYthph..lhlpcpls+tLsls	...............................................................................s.s-pLp.phsppNhssWhlsllccshshspp+clolsELsW.WA.lpNpl.................sDsL..............PEushR+uL....t...l.t..c.tlpohh....RESDIlPu.c.psA.T...sIl.pp+sK.....................cpVlultVDPESPt........Sahp+.......sKh+.Rh.........ccYTRW..VKoQsCss.C.....G.......KP.AD.......DPHHl...........I.GHG..p.GGMG.T.....Ku.aDlFsL.PLCR....cHHs......E......LHA..s...shuFE..-KaGSQl...LlhRFls+Ahsh..........................................	0	11	27	47
+5976	PF06148	COG2		COG (conserved oligomeric Golgi) complex component, COG2	Finn RD	anon	Pfam-B_9559 (release 9.0)	Family	The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function [1]. The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs [2].	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.47	0.71	-4.28	19	316	2012-10-03 17:31:52	2003-05-30 09:15:08	6	10	269	1	222	448	1	134.30	27	23.60	CHANGED	LsFscspFht................................................ssFssspFlpp.ppptssL-pLpp-LctY.phLcppllcLlNpDYtD.FVsLSssLhGh-cplppl.................cssLtphpcclpuh+splptthpclpsplpc+pplcpp+....phLchLlphtpsls+lEcll	...............................................tpttFht..................................................ssF.D.s...-pFls..........p...s..........c.....+..ts..sL-s...L...+...s...-...Lcth...h....phLpspll-LINcDYsD.Fls.......LSs...sLsG..h.-.....c....t.....lppl..................ps..sL...t...p...h...+.c..c...l..ts.l..+s.p.....l.ppthptlpptlpcpcplcppc.......thlptllpl.hcplpclEph................................................................................................................................	0	73	126	185
+5977	PF06149	DUF969		Protein of unknown function (DUF969)	Finn RD	anon	Pfam-B_9723 (release 9.0)	Family	Family of uncharacterised bacterial membrane proteins.	24.20	24.20	24.30	29.80	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.23	0.70	-5.09	29	934	2009-01-15 18:05:59	2003-05-30 09:23:58	7	2	917	0	119	446	13	214.90	46	92.60	CHANGED	hhsLlGlsllllGFhL+aNslLVVhlAullTGLsAGhshhclLsslGpuFlssRhlolhhLl.LPVIGLLERaGL+E+ApshIs+l+uATsGRlLhlYLllRploAAlGL.uLGGHsQhVRPLlAPMAEuAAcsphG....cLscpp+-+l+AhuAAsDNlGhFFGpslFlAhGulLLhpuhLcph.Ghp.l-shplulauIPTAlsAhlIauhRhhhhD+pLt+	....hlhLlGIsllVlGFhL+hsslLlVhlAGllTuLluGhuhs......clLphlGcsFlssRslslFllh.LPllGLLERaGLK-pAtsLIpKlKuhTsG+lLhlYhhlRplsAAhul.slGGHsQhVRPLls..PMAEuAAc.sphG................cLscc.c-clKAhAAAs-NhGhFFGpslFlAsGulLLlpuhlcph....Gh.c..lp....shplAlhuIPsAlhAllltulphhLhD++Lt+..........	0	26	59	93
+5978	PF06150	ChaB		ChaB	Bateman A	anon	Pfam-B_7743 (release 9.0)	Domain	This family of proteins contain a conserved 60 residue region.  This protein is known as ChaB in E. coli and is found next to ChaA which is a cation transporter protein.  ChaB may be regulate ChaA function in some way.	20.60	20.60	22.50	22.20	19.50	18.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.76	0.72	-4.17	56	786	2009-01-15 18:05:59	2003-05-30 09:37:16	7	2	707	1	126	393	17	63.10	55	67.80	CHANGED	LPtslp.pLPt+ApcIahcsFspuhcpa..ts...........EpsAt+lAWsAV++cYhK.hssc...W..ls+s	..........LP-oV+pVLPuHAQDIY+EAFNSAW-QY..KDttcRR.scsSREETAHKVAWA.AVK+-YtK..s-DDK...W+KKp.............	1	32	76	101
+5979	PF06151	Trehalose_recp		Trehalose receptor	Finn RD	anon	Pfam-B_9846 (release 9.0)	Family	In Drosophila, taste is perceived by gustatory neurons located in sensilla distributed on several different appendages throughout the  body of the animal.  This family represents the taste receptor sensitive to trehalose [1,2].	20.30	20.30	20.40	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.33	0.70	-6.12	8	405	2012-10-01 21:54:26	2003-05-30 09:38:08	8	5	31	0	147	529	0	255.80	24	92.58	CHANGED	Mppot..hcK.........................................pahp.soFHcAluPVLhlAQhFulMPVsGlpup.cPccl+FpWpSlphhaoLlhhlhshschuhuhphVhssulshcolssLlFhlssllsalsFlpLARpWPpIhRpWstVEphhhpssYp.ht+tshu++lpllullllssuLsEHhLhhsSuhh.sshphppCc..hs..shpsYhhpppsplFhlhsYosahshhhcahNsshTFlWNFhDIFlMhluhGLutRFpQLspRlcpht+psMspsaWpclRpcalsLscLlchlDcAlSsllLlShuNNlYFICsQlL+SFpshs.shhctlYFWFSLlaLluRThhlhLsASSIsDEu+csLpsLRpVPocuWCsEVpRFuEpltoDpVALSGh+FFhLTR+LlhuMAGTllTYELVLlQhppsscltp....C	.........................................................................................................................................................................................................................hhhuphhshhPl.sl......ttl.pF.thhs..hhhsh.......h.h....hh........h.h.h.h....h.h..h.p......shph........p............sh.h.h.hhh..h.hh.hu.pW.s.lhh.htth-...h.......ht.......ththtpp...l.hhhhhh....h.hu.........................................................................................................................................................................htph...h.......................................................................h.......+..h.th..hh..hp..t.ht..h..............................................................................................................h.........h.a......h...h....s..h...hhl.R..........h........h...h...s.u.l.......t..................h.........h........................a....t...........p........h......h........h...h.........hsu.t.a.hp...h........................................................	0	46	60	120
+5980	PF06152	Phage_min_cap2		Phage minor capsid protein 2	Finn RD	anon	Pfam-B_9879 (release 9.0)	Family	Family of related phage minor capsid proteins.	21.30	21.30	21.60	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.08	0.70	-5.47	9	238	2009-01-15 18:05:59	2003-05-30 09:44:04	6	7	205	0	35	224	6	309.60	23	78.56	CHANGED	M.....tl..sspph.h.st.hsDlYstLpt-lhsphlcplKsptsh......upshhpWQhpKLsclthLsppslchlu+hoGhspctlpphlcssGhpshpsh-ptlscs.................lppt.........hpshtshl.phLsuYtpQshscL.NhlNpTlLpo......s.tsYpsIIpcT.................sstllsGhKT.ppAlcpsltcahcpGlsu.hlDKuG++WohEuYsRsVl+TTstpsaNchcpc+hc-YGlclshhSpHsuAR.tCuPlQG+ll..ssputsppp.ssK...Y.ul.s....huYGsPuGhhGlNCpHphhPaIsGVsp.....spp.phD.c-stcshphppcQRhhERpI+phKcphhhtcphsDcchhthtpptVRphQstl+thlpss	...........................................................................................................................................................h.phapthp.plh..hhcplht................tp...Wph.phpphthhpp..p.hphlsph.s.stptlpphhp...pthhphhpp..hpp.h...t.........................................httt.....................t......t..pphl...psh....p...ps.hpsh...p.hspsh.tp...............htphYpph.lpcs.................h.hp.h.s.Ghh..oh.ppA.lppsl.hp......hhppGl.s..hhD.p...u.....G.....+...paph-s...Yschslposstpshsphptpthp-h...Gh-..hh.lStHssAR........s........t.........C......u.......hQGclh.........hht.............s.c....a.s.l.s...........hthu...p....ssG.........hhGhNC+Hhhhsah..Glsp...............pp...hs.......c......p......s.....p.............hp...hpppQ..Rh....hERpIRptKcchh....h.tc.th....t.c.......tp................hpthpttlp..thptthpphlpt........................................................	0	15	29	32
+5981	PF06153	DUF970		Protein of unknown function (DUF970)	Finn RD	anon	Pfam-B_9915 (release 9.0)	Family	Family of uncharacterised bacterial proteins.	21.10	21.10	21.10	21.10	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.30	0.72	-4.09	11	826	2012-10-01 21:59:08	2003-05-30 09:47:45	6	1	766	3	149	414	5	106.90	52	98.97	CHANGED	MKLlIAIVQDpDuscLhcuLs-psFcsTKLAoTGGFLKuGNTThlIGlED-+V-cllolIK-sCpsR-plVsshuPhusssDsYlPaPVEVpVGGATVFVlsVEpFhph	................MKlIlAIVQDpDSscLucpLlcss.a.RATKLATTG....GF....L+uGN........TTF.llGl-D-RVD-lLslIcp.sCpsRcQ..hV.o.s......ss.h...s...s.o..s-...u.a....l..PY.PV.EVpVGGATVFVhPV-tFcph..........................	0	68	112	135
+5982	PF06154	YagB_YeeU_YfjZ		YagB/YeeU/YfjZ family	Bateman A	anon	Pfam-B_7771 (release 9.0)	Family	This family of proteins includes three proteins from E. coli YagB, YeeU and YfjZ.  The function of these proteins is unknown.  They are about 120 amino acids in length.	25.00	25.00	27.00	27.00	24.10	23.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.23	0.72	-3.80	10	822	2009-09-10 17:55:17	2003-05-30 09:48:58	6	2	339	6	28	413	9	90.00	81	87.89	CHANGED	sssPpWGLpRslTPpFGARLVQEGNRLHYLADRAGlsGpFS-spsp+L-cAFPphlKQLEhMLtSGELsPRpQHCVTLYpsGLTCEADTLGSaGYVYIAIYPTpt	.....................PphsARLVQEGN+LHYLADRAGIRGtFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPc...................	0	5	7	15
+5983	PF06155	DUF971		Protein of unknown function (DUF971)	Moxon SJ	anon	Pfam-B_10230 (release 9.0)	Family	This family consists of several short bacterial proteins and one sequence (Swiss:Q8RZ62) from Oryza sativa. The function of this family is unknown. 	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.14	0.72	-3.57	109	1053	2009-09-11 11:45:35	2003-05-30 09:50:28	7	18	818	6	442	927	860	84.50	30	39.78	CHANGED	oplplpp.ts.+hLplsasDGp...................p...........hplssEhLRVtSPSAEsp..............GHtsspp..............hh.suKpsVsIpsl-PVGsYAl+lsFsDGH-oGlYoWsYLh	..........................................................................l.hpp..tp.+hLplpass..Gp...................p..hplstchLRshsPuA-sp..............s+ss..spc.....................hh..ss+.psVp..lt..s.l...c...s.l.G.p...YA..l.plsF....s..D...G.Hso.......GlasWsaLh............................................	0	150	254	350
+5984	PF06156	DUF972		Protein of unknown function (DUF972)	Moxon SJ	anon	Pfam-B_10235 (release 9.0)	Family	This family consists of several hypothetical bacterial sequences. The function of this family is unknown.	30.00	30.00	30.00	30.30	29.80	28.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.72	0.72	-3.70	43	1035	2009-01-15 18:05:59	2003-05-30 09:54:09	8	1	1029	0	114	334	1	105.50	41	94.11	CHANGED	M-Kp-la-plsphEppltphhpplspLKppltpllEENspLclENp+LRc+Lpchpt.........................ppppsppt........hucuh-NLt+LYpEGFHICs..haYGp+R.p-E-.ClFCLs	................................MDK+-lF-slsphcppltphhp-lpplKppltpLlEENssLclENpcLRc+Lscl-t...................................tcs.hc..............htcu+-NLtplYpEGFHlCs...aYGp+R..p-E-ChFClp....................	0	36	66	90
+5985	PF06157	DUF973		Protein of unknown function (DUF973)	Moxon SJ	anon	Pfam-B_7947 (release 9.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	21.30	21.30	21.40	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.91	0.70	-5.44	8	109	2009-01-15 18:05:59	2003-05-30 09:57:02	6	3	37	0	58	97	7	227.70	21	91.95	CHANGED	sElpGlpKLRsGsLahlluslluhIshIlhls......................s.h.hhs.h.shltsulhllIlsll...lslluhl+l+SGFsILs.usu+DlGhGtTGshLlllGhllllIGsl...lslh..................lhuh.llaIGsILslIGtILlGluhY+lGchYsssllKlGGILllIsI............lsFIGaILsYlGLscVhsph...............tPhsshps.usplpQVGhGsL+uNGhAplTlYSphpssIlSApI-GTNhpso..pIsPthLpsGpNsIpIpFs.sssshlsGohYhlsLsls...Nu.slplsllYQP	................................................................h.ult.l+pG.lhhhlh.ll.hlh..hhhh..................................................hh..h...h...hhh.hthl......lhl...ls.h.h.h..h.ppGF..Lt.pht...shthG.....hus.l.hl.luhlhhl..huhl...hsl.......................................h......lh...hlu..llh..hlGhlhl.s.h.shhplGpha....p.pshhphuGIlhhlsh.......................................lshlGhI.lhYh...ulspl..ht................................................................................................o.....tl.p..l...sh...h.s..........s..l..G.N.l.h.h........h..tt.Y.l.l..t...s.....h.h.h............................................	1	14	23	48
+5987	PF06159	DUF974		Protein of unknown function (DUF974)	Finn RD	anon	Pfam-B_9042 (release 9.0)	Family	Family of uncharacterised eukaryotic proteins.	25.00	25.00	25.80	26.20	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.76	0.70	-4.92	19	285	2009-01-15 18:05:59	2003-05-30 10:02:37	8	7	233	0	202	302	2	228.30	33	55.68	CHANGED	LsLPpuFGslYLGETFushlsssN......................sospsVpsVslcAEhQTsop......................+lsLtsssss..ssst.........................................lpsspslppllpa-lKE.GsHlLsCoVsYpps.........uGc....p+tFRKhapF.s.psPLsV+TKhtshts..........................chhLEAQlENho..psslhL-pVpL.-ssptapssslsh-sshss..ssph.t..........................................sh.LpPs-.scQhlFhlp.cst................sppstthcspsslGpLsIsWRoshG-+GpLpTupLtpp	..................................................LsLPtsFGslalGE..TFushlslpN.......................ssspsl.pslhl.cA-lQTsop......................+lsLs..ss.s.ss.......ssp.........................................Lpssss.lscllca-lK.......EhGsHlL....sssVoYsst..........................sGc..........................phhFRKhapF...s.hpP.L.sV+TKhhshpst....................................................chaLEAQlpNho..sushh..h-.................pVp..L.-ss..a..pssplN.....sptsp...s..p...............................................sh..L..p.Pt-..spQalaplc.ctt...........................htps.hhhcuh.s.sl.G.cLsIsW+o.shGE+GpLpTupLtp.h..............................................................................................	0	69	106	160
+5988	PF06160	EzrA		Septation ring formation regulator, EzrA 	Finn RD	anon	Pfam-B_9703 (release 9.0)	Family	During the bacterial cell cycle, the tubulin-like cell-division protein  FtsZ polymerises into a ring structure that establishes the location of  the nascent division site.  EzrA modulates the frequency and position of  FtsZ ring formation [1].	32.70	32.70	32.80	32.70	32.40	32.60	hmmbuild  -o /dev/null HMM SEED	560	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.75	0.70	-6.33	37	1051	2009-09-13 07:39:20	2003-05-30 10:10:28	7	3	1032	0	101	562	3	545.60	34	97.35	CHANGED	lllulllllllhhhsshhh+++hhcpIccLEpcKpclhshslp-Elpcl+pLpLsGpopppFccWcpcas-lsssphsclEchlh-AEshscpa+Fh+A+ptlsplcshlsthEpplcpIpptlscLhps-ccNptplpphcctYcpl+KslLspsapaGsuhstlEcpLppl-pcFppFspLspsGDalcAcclLpplccchtpLpphhccIPsllpclpsshPsQLp-LcsGYcchhppsYhhsc.hslcpclpplppplpps.stL.ppL-l-cspppsppIpccIDpLY-lhE+ElpA+phVcpptpplsphlp+spppsppLttEl-+lppsYtLscsElpps+phppclpplppphpphtcplspppssYStlp-phcph.cpLcpIccpQtclpcplpsLcc-EtpA+cplppacpclpplcRhlc+pNLPGlPpsalphhhpsssclcplsccLsph.lNh-plsctLp.spsslcpLcccop-llpsAsLsEpllQYuNRYRspppplppuhpcApplFcp.acYppul-hlupALEplEPGuhcRlpcsY.p	..............................................................................................hlluIllll.l.l..shslth..h.l..R....++.pppp.l-tLE-RKpE.lhsLPls-ElcplKph.p.Lh.Gp.o.pst.FccWppcWs-lospph...uclEppla-AEsh.scpF+Fh+Apptlsphpptls.hEpslppIhpsLs-Lhcp-ccNstclpcsh-hYc-hp+pVhsspcpaGpAhsplEcpLcslpscFspF.sLsssGD.lcAppllsshccchhtLpphh-cIPsLlpchppplPsQLpDLc.t.GY+cLhc.ps..Yphs.c.hcl-pclpplppplcpspttl.ppL.-L-pAptcstplp-cIDslYDlhE+ElcA+chV-pppshlschLp+h+cpNppLtpElpclppsY.hLs-..s-hppl.R..php..s-lpplppsh....pclt.pphpcp.shsYS.lp-pLcpl.cplpsIcccQhcl.......pcpLpplcc-EhpAccplpphpsclcpl+Rhhc+pNLPGlPpsalp.hhhpss...pplccl.ppLppp.INl.cplschlphsssshpsL-ccopcllpsAsLsEpL.lQYuNRYRppcp.....plpcuhscA.clFcp.acYctul-hhupALEplEPGlsp+ltppa.............................................................	0	24	53	77
+5989	PF06161	DUF975		Protein of unknown function (DUF975)	Finn RD	anon	Pfam-B_8494 (release 9.0)	Family	Family of uncharacterised bacterial proteins.	29.20	29.20	29.30	29.40	29.10	29.10	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.88	0.70	-4.63	12	1830	2009-01-15 18:05:59	2003-05-30 10:32:24	6	8	936	0	225	1227	109	171.80	22	89.60	CHANGED	M........oppElKphA+ppL+spWGsslLlhllhhl...........hhhshhlshhtshs.p.h..............llhhllsshlphushhshlcls+p..ppsphppshssF...cpFhphlls.lLhslhhhLaull.hh.h.l.h...................................hhhh..hl.llh.ullhs..htYS.s.alLh-p.c....hGshcAlscStphMKGhKWchFlLpLSFlGW.............................hlLshloh....................Glsh........laLl.........PYhpTsphhFYcsltttp	.............................................................................................................h......th+..t...h...p................hh......h........................................................................................................................................................................hh..h..h....h....h..u.........hh..lth...ct....tp...t....h..t.........h...hh......t.h.........hh.h.....l.h..h.h.h.h..h......................................................................................................................l....h.....h....hh.hhhh.....htat.....s.a.lh...hp.t.p.........hs.....phhptShthMpG.+hph.hhL..Lphls..W.................................................hhLs..h..h....sh..................................u.ls.........................................hhl........................PYh.....hs.h.aYttl.............................................................	0	77	151	182
+5990	PF06162	DUF976		Caenorhabditis elegans protein of unknown function (DUF976)	Moxon SJ	anon	Pfam-B_10032 (release 9.0)	Family	This family consists of several hypothetical Caenorhabditis elegans proteins of unknown function.	24.40	24.40	24.40	24.40	23.30	22.90	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.94	0.71	-4.73	6	29	2012-10-01 19:48:29	2003-05-30 10:42:21	7	3	6	0	27	54	0	151.70	37	68.88	CHANGED	MLSMCN+aPhF-ssc..RhVh.phacllTVFDss.puppPSsAVIVa-ELsKus.ssphLsh.KMEpSYtKVDplspchsspph+aAIHLuSHS.KNsIQIhpoAaSsGYTpcDKcGplPEGsKVKCsGsETsh+TpVsCEcVVK-VNEah-ps+pKFG-Lclpshpc	.................................................hCp.....................sl.VTuFs..s..s.h.Et..p..sPS.ssV.l......DELhKps....ssphl.h..K..h.phuY-cVsc+l....PEL.h.p.p..p.s.chslHLu.sHslcN..sIhhpppAFusGYsppDh.sG.h.lPE.GN.+..s.....p.s.....s.....sp-.....p...sh+oplcC-pLVccVsE+hsLDGp.K.aGGLpVcpS-...............................	0	12	13	27
+5991	PF06163	DUF977		Bacterial protein of unknown function (DUF977)	Moxon SJ	anon	Pfam-B_10135 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins from Escherichia coli and Salmonella typhi. The function of this family is unknown.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.73	0.71	-4.39	3	656	2012-10-04 14:01:12	2003-05-30 10:44:53	6	3	360	0	19	337	25	123.10	59	90.83	CHANGED	MAKPFTQEEREcIKuRIIGLVRcsGRhTlsQLEstTGAsRaosc+hLR-lLAsGDlYpsG+hGlFsSEQAh+sWppAtcKh..........sD.sLIhp.PDGEIRRYDSpQNI...ICsECRKSEVMQ....RVLAFYQGNFQ	..................MAKsFTpEEREcIKupllELVRpSGRcTlRQL..EsKTGATRahhphLuR-LVASGDVYp.SGh..G.lFPSEQAh+DW..ppARcKh...........sDPsLIhpLPDGEIRRYDR+.NI....ICpECRcSEsMQ....RVLAFYpGsh.......................	0	3	9	16
+5993	PF06165	Glyco_transf_36		Glycosyltransferase family 36	Finn RD	anon	Pfam-B_9110 (release 9.0)	Family	The glycosyltransferase family 36 includes cellobiose phosphorylase  (EC:2.4.1.20), cellodextrin phosphorylase (EC:2.4.1.49), chitobiose  phosphorylase (EC:2.4.1.-).  Many members of this family contain two copies of this domain.	20.60	20.60	20.90	20.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.03	0.72	-4.21	116	1154	2010-01-08 16:32:43	2003-05-30 10:48:30	6	29	637	23	350	1064	71	109.20	27	9.38	CHANGED	DssGpahYlRD.poGchWSsohpPs....p.sss...tpYp..spaG.uhupFpppp......sslpsplphh.Vsh-c....ssElp+lpLpNpuscsRplplToYsEh.VLusstsDpup.thophhspo	............................................DpsGcalYl..R...Dtp..........o...G.........c...hWSsohpPs...................p..pss....t.pYc.........sca....GhuaopFppp.t......sslpsphphh.Vs.hcc.....ssElpclplpN...pos..csRp.lplhuYsEh.sL.u.s.h.p.s-ssphhhsph............................	0	112	228	276
+5994	PF06166	DUF979		Protein of unknown function (DUF979)	Moxon SJ	anon	Pfam-B_10323 (release 9.0)	Family	This family consists of several putative bacterial membrane proteins. The function of this family is unclear.	25.00	25.00	63.00	63.00	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-11.96	0.70	-5.46	30	939	2009-01-15 18:05:59	2003-05-30 10:50:52	7	3	918	0	123	458	15	303.60	46	97.51	CHANGED	L-hlYhLhGllhlhhAhhohpD+sp..P+RaGoulFWulhulsFlhGs.................hlPshssGslVlshullAuhttlshGphppsssp...ptcptAp+LGN+LFlPALhlPllollsuhh.hspl................uoLlulGlGsllAlllAhhhT+sp.stpslpEucRLl-ulGWAulLPQhLAsLGslFssAGVGcslupllushlPtssthluVlsYslGMALFThIMGNAFAAFsVhTAGIGlPhllsphGGNPAlhuAlGMhuGaCGTLhTPMAANFNlVPAALLEl+D.+.uVIKsQlPsAlsLLllsIhLMYaLsF	...............-hhYhlhGllhlhsAhhshcD+ss..PpRhGouhFWslhulsFlhGs.................hlPs...hshGhlVllhullAhhptVphGphc.phsc...p...ctptpAp+LtNKlFlPALhlsllsllhuhh.hspl.................................sollululusllAhlsuhhh..T..+sp.PppslpEusRhlpplGhuuILPQlLAsLGslFssAGVGcllu+llusllPs-shFluVhsYslGMsLFThIMGNAFAAFsVlTAGlGlPhllth.GuNPAlhuAluMhuGYCGTLhTPMAANFNlVPAALLEh+D.cNGVIKAQhPsALslLlhpIhLMYhLsF................................	0	26	61	94
+5995	PF06167	Peptidase_M90	DUF980; MtfA;	Glucose-regulated metallo-peptidase M90	Finn RD	anon	Pfam-B_8651 (release 9.0)	Family	MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity [1]. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase [3], whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.	20.90	20.90	21.30	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.39	0.70	-5.00	74	1002	2012-10-04 10:46:43	2003-05-30 10:52:23	7	4	957	2	233	631	88	237.40	45	88.21	CHANGED	Mh.......h..............htht+cppltppshs....shWpphlpp.lPhhptLsss-ptcL+phsplFLscKpapGspGlplTDph+lsIAAQACL.lLpls.....hsaYsshppIllYPssFlsppptt.....Dcs..GlVHchcpshsGEuWpp.GPVlLSWpslhtus............st-G....aNVVIHEFAHKLDhhsGs.AsGhPsL....tss.h.......shppWspshppsacphppphptspp...................shlDsYuAssPAEFFAVsoEsFFppPptltppaPplYptLspFY+	.................................................hhhh..................phpcthp..p.pslP......WpcsLs..lPlLssLotpEpt+L.hslAptFLppK+ls.s.....lpGhE.LsshhpspIAhhhCLPlLcLG.....l-Wh-GF+EVLlYPusFVVcccac.....D-hGlVH...stchlpSGpSW.pQ.GPllLsW.DlQcoh............ssuG....aNLlIHEhAHKLDhc..NGc.AsGlP.h.l.........sh.p........-lsuWc+.sLc.s.Ahsslpccl-hss-t.................tusIDsYAAocPAEhFAVlSEYF......FoAP...-LhtscFPuLapphspFYp.........................	1	73	138	190
+5996	PF06168	DUF981		Protein of unknown function (DUF981)	Finn RD	anon	Pfam-B_8691 (release 9.0)	Family	Family of uncharacterised proteins found in bacteria and archaea.	28.50	28.50	29.00	29.80	28.30	28.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.34	0.71	-4.52	13	68	2009-01-15 18:05:59	2003-05-30 10:55:04	6	1	57	0	29	64	5	187.60	30	95.22	CHANGED	Mu.........FIDsLslhLhsLuhshllhAhhhlpshlshc.......cculcsuhhPhh.sLGlhhhloGlauphTW......PLPuSY...NILFhDsahlhGlhlluhululapshc...............LcshuhhuLhlGLhsIhYGssshtasL.Tt-P...............l.AhLuLYhlsGLAulL..ssslhlDphctpt.............lhhllthlhLlluullAhaIGhpAlhuHL..s.sas	..........M...FlDsLslhLhhlshshllhAhhhhtshhsht...............................cpshscshhPhh.slGlhhllhGlauphTW......PLPu...SY....NILFhDsahlhGlslluhululhh.s..hc..........................Lpshuhh..ulhhGLhsIhhGsuhhsauL.TpcP................h.uhLuhahhhGLAulh..ssslhhpp.p.t..............hhhhlhhlhLhluulluhhhGhtuhhuHlst..s.......	0	13	18	24
+5997	PF06169	DUF982		Protein of unknown function (DUF982)	Moxon SJ, Eberhardt R	anon	Pfam-B_10431 (release 9.0)	Family	This family consists of several hypothetical proteins from Rhizobium meliloti, Rhizobium loti and Agrobacterium tumefaciens. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	22.20	22.20	22.20	25.10	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.49	0.72	-4.24	51	308	2009-01-15 18:05:59	2003-05-30 10:56:52	7	2	50	1	157	327	1	74.20	29	77.43	CHANGED	ppPVtlthss.tthp.tlpost-AhchL.pcWPh.p..cG.tapsAl+sCtsAlsGphssppARcAFlsAAccAsl.hh.s	.......t.pPVtlthss..s.thp.plpost-AhchL..pcW.Pt..p..cG.tapsAlcsCtsAlsG..ptsspsARcAFlsAAccAslhh..t..........	0	7	49	64
+5998	PF06170	DUF983		Protein of unknown function (DUF983)	Moxon SJ	anon	Pfam-B_10629 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function.	21.30	21.30	21.30	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-9.95	0.72	-3.87	62	469	2009-01-15 18:05:59	2003-05-30 10:58:27	7	4	239	0	180	411	137	84.30	38	61.56	CHANGED	FcuaLKlsspCssCG.-hsatcusDGPAahsIlllGalllshhlhl-hsapPshWlphsl..ahPlsllhsLhLLpslKGhllulQas	.....FcuFLplsspCssCG.Dasatc....u.sDG.PAahlIl..ll.GallVshhl...hlEhsh.s.s.shWlahsl..ahPhsllh.oLhlLpslKGhlluhQa............	0	50	108	132
+6000	PF06172	Cupin_5	DUF985; 	Cupin superfamily (DUF985)	Finn RD, Bateman A	anon	Pfam-B_9217 (release 9.0)	Family	Family of uncharacterised proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.	25.00	25.00	25.60	25.20	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.87	0.71	-4.27	19	1200	2012-10-10 13:59:34	2003-05-30 11:06:00	6	9	1116	34	350	843	354	132.00	40	81.62	CHANGED	ApplIcpLsLpsHP.EGGaa+ETaRussphs.s..............RshsTuIYFLLsp..sshSpaHRl.cu-EhWHaauGssLplhhhsssGphps.....hpLGhDl.ttGpps......QhlVPsGsWhuu....................ps.ssaoLVGCsVAPGFcFcsFELhc	...................................pphIcpLpLtsHP.EGGaa+cTh+ustphst..............................................RuhhTuIYFL.Lps.........ssh............S+..aHRl.su.DElWa....aa.uGs.sLplahl.s......s......-...G..p...h.ps............................hpLGhDl...tpGp.p.......................QhsVPtGshhuu..............................................pssssau...LVuCh........VuPGF-FccFELh............................	0	101	206	283
+6001	PF06173	DUF986		Protein of unknown function (DUF986)	Moxon SJ	anon	Pfam-B_10711 (release 9.0)	Family	This family consists of several bacterial putative membrane proteins of unknown function.	22.20	22.20	22.30	22.50	21.40	22.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.99	0.71	-4.39	12	608	2009-01-15 18:05:59	2003-05-30 11:09:38	7	1	599	0	47	234	2	144.70	70	97.43	CHANGED	TslhLllhIshhLhYAhYDpFlMsh.hKGKThLpVpLK++s+lDulIFlsLIuILl.YpNhts..pGs.lToaLLssLsLlulYluaIRtP+llFKppGFFauNlFIpYu+I+pMNLSEDGlLVI-L.pp+RLLlplpplcDLEKIhphhsphp	....TDLVLILFIAALLAaAIYDQFIMPR.RNGPTLLuIsLLRRGRlDSVIFVGLIs...ILI.YNNVTs..HGAhlTTWLLSALALMGF.YIFWI..RsPKIIFKQ+GFFFANVWIEYuRIKsMNLSE....DG...VLVMQL.EQRRLLIRVRNIDDLEKIYKLLlss........................	0	4	14	32
+6002	PF06174	DUF987		Protein of unknown function (DUF987)	Finn RD	anon	Pfam-B_9329 (release 9.0)	Family	Family of bacterial proteins that are related to the hypothetical  protein yeeT.	25.00	25.00	36.80	36.70	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.15	0.72	-4.46	3	583	2009-01-15 18:05:59	2003-05-30 11:12:23	6	2	284	0	11	152	0	65.30	91	89.63	CHANGED	M+IIo+tcAMcIaRQHPuSRLFRYCTGKYQWHGSAsHYTGRDVsDIoGVLAVYAERR+DusGPYlc	...............MKIITRGEAMRIHpQ...HPASRL...FPFCTGKYRWHGSAEAYTGREVQDI.PGVLAVFAERRKDSFGPYVR.....	0	4	4	8
+6003	PF06175	MiaE		tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)	Moxon SJ	anon	Pfam-B_10761 (release 9.0)	Family	This family consists of several bacterial tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) proteins. The modified nucleoside 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) is present at position 37 (3' of the anticodon) of tRNAs that read codons beginning with U except tRNA(I,V Ser) in Escherichia coli. Salmonella typhimurium 2-methylthio-cis-ribozeatin (ms2io6A) is found in tRNA, probably in the corresponding species that have ms2i6A in E. coli.  The miaE gene is absent in E. coli, a finding consistent with the absence of the hydroxylated derivative of ms2i6A in this species [1].	20.70	20.70	21.20	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.73	0.70	-5.00	6	1063	2012-10-01 21:25:29	2003-05-30 11:15:23	6	3	665	4	298	910	594	146.00	32	95.80	CHANGED	phLsPlhpFLpCsTPpsWlEpAht.tsLDllLLDHptCEhKAAtoAh.Llt+Ys..................................................PhspcLlschstLh+EEL+HFcQVhplhctRsIshsslsAuRYApuLhutVRTpEPppLlD+LlVGAaIEARSCERFAtLAPaL.DsELAKFYsSLL+SEARHapDYLpLApphuuc.DlScRlphhutlEAELIpoPDsEFRFHS	...................................L....Ts.tWl..s...tp...hL.DHh.CE.KAutsAh.hhhpa.................................................................tL.t.h..lhpEEh.Ha..Vhthh.t+sh.h.......ts.Ystthht.h..p....p...........p..........hh.hD.Llhuuhl.EARSpERhthls..............h.....-......pl.tpaYhtLh.SEupHat.ah.hA.ph.........t..........................ltt+ht.hh.hEtp....ll....t.......t.......phH...........................	0	81	175	256
+6004	PF06176	WaaY		Lipopolysaccharide core biosynthesis protein (WaaY)	Moxon SJ	anon	Pfam-B_10767 (release 9.0)	Family	This family consists of several bacterial lipopolysaccharide core biosynthesis proteins (WaaY or RfaY). The waaY, waaQ, and waaP genes are located in the central operon of the waa (formerly rfa) locus on the chromosome of Escherichia coli. This locus contains genes whose products are involved in the assembly of the core region of the lipopolysaccharide molecule. WaaY is the enzyme that phosphorylates HepII in this system [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.50	0.70	-5.14	4	512	2012-10-02 22:05:25	2003-05-30 11:21:56	6	5	478	0	34	372	53	198.00	52	81.44	CHANGED	MIhpp+I+shsVFhK-NssKYhplhsDFLoYshpslKVFRsIDDTKVhLIDTcYG+hlLKVFuPKsKpsERFhKShlKGDYYEpLhhpTDRVRsEGlpulNDFYLLAERKTLpas+sYIMLIEYIEGVELsDhP-IsE-lKscIppSIcpLHpHGMVSGDPH+GNFIlppstlRIIDLSGK+soApRKAKDRIDLERHYGIKNElKDhGYYhLIY+KKlRphlR+lKGK	.................................................................................................................................MI.p.ph.pshphahccss.hY.plhp-hLshphphlKVhRs.I-.DTKV.L..IsT..th.G.hlhKVauP.Kh.Kh.sERF..h.KS....h....l.K.t...DYYc....pL.hhp.TD.RV...Rs.....EGh.pslN.Da.a.L...LAE.+.K....T....L..p...a....s+h..Y.......lMlIE.........YIEGlcL..s-...h...................-......I.......s......-......-.......l....K......s........c.......l......p.....p.S.....I.....c.......c.....L.....HpH.....GM.....VSGDPH+G.N.F.I.l...p..p..s..t.....lR......lID..L......S..GK..+..s..o..t....h..K......A+..D.R.l..sh..E..R..H.h..sItNp.....l....+D.h.GahhlIa+.pK.l+p..h..l+clKsK..............................................................	1	8	19	25
+6005	PF06177	QueT	DUF988; 	QueT transporter	Moxon SJ, Rodionov D, Bateman A	anon	Pfam-B_10800 (release 9.0)	Family	This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes [1-2], suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	21.30	21.30	21.40	21.30	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.86	0.71	-4.24	45	1266	2012-10-03 02:46:00	2003-05-30 11:23:59	6	1	1098	0	152	637	4	152.20	33	91.44	CHANGED	slstsAllAAlYllLTlh..lsslSaGslQFRlSEhh.NhLsh...as+.+YIhGlslGshIuNlh.Ss.h....Gll..DllhGshuTLlsshlshhltchhpph.hh.......phhlsslhhslsh.hhIAh.pLshhhp.......l....PF...........hhT....a.holulGEhlsh.llGssllhhlsKplc	..................lsphAll.AAlYllLTlh....lsslS..a.G.shQFRlSEhh..N.hL..sh...ash...KYlhGlslGshluNla....os..h.......Ghl.DllhGshsTllslsls..hhltt...phtt...h..............phhhsulhholsh.h.h..l.Ah...Lsh.hhp...................l......P..F.............ah..o....a....hosulGEhhsh.llGs.lhhhlsK+l................................	0	69	110	132
+6006	PF06178	KdgM		Oligogalacturonate-specific porin protein (KdgM)	Moxon SJ	anon	Pfam-B_10852 (release 9.0)	Family	This family consists of several bacterial proteins which are homologous to the oligogalacturonate-specific porin protein KdgM (Swiss:Q934G3) from Erwinia chrysanthemi. The phytopathogenic Gram-negative bacteria Erwinia chrysanthemi secretes pectinases, which are able to degrade the pectic polymers of plant cell walls, and uses the degradation products as a carbon source for growth. KdgM is a major outer membrane protein, whose synthesis is strongly induced in the presence of pectic derivatives. KdgM behaves like a voltage-dependent porin that is slightly selective for anions and that exhibits fast block in the presence of trigalacturonate. In contrast to most porins, KdgM seems to be monomeric [1].  	20.40	20.40	20.50	21.20	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.56	0.70	-4.84	7	1133	2012-10-03 17:14:37	2003-05-30 11:29:46	8	1	545	2	73	394	5	209.70	33	93.83	CHANGED	lusss.A.shl-hRctYppsoct..cshltlupphspGhGh.l-s......sss.pspt.s-httshNEls.hsh.aKssDphslpPGh.lpstsssSsYpPYL+spYphssshslslRYRapapphous.hcs-pss.ct.chssahsYplhc...paphsap.p.ahcsspap...ussccppaEhssphtY+h.sppWpPYlEls.lshsss....sscR.QsphRVGlpYpF	........................................................................sh.s.A..shl-.Rct....Y....t........sS..ct....cshlt...lu...ph.s.GhGh.l-u.........................sssh.p.sp..+.h..s.-httsssElp.hsYhaKh..s.D.pholpPGh.l.h............c.................ss.Ss..uo.tYt...PYl+lsashs..s..shshulRYRYsa...psh....s.....s...s...s...h............s............u............-.........h...........ss...p....ssa..ch........ssYhsYplss.....cF.sasapsp.h.ahc..s..s.cap...............huNscKa.sa.EhshshpY..+h....s....p...p....apPYhEl.s.....lsppss............sD..cR...Qspa..RlGlpY.F................................................................	0	3	17	46
+6007	PF06179	Med22	SURF5; 	Surfeit locus protein 5 subunit 22 of Mediator complex	Moxon SJ	anon	Pfam-B_10889 (release 9.0)	Family	This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1.  The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organisation is similar in human, mouse and chicken Surfeit locus.  The Med22 subunit of Mediator complex is part of the essential core head region [2] [3].	21.20	21.20	21.20	21.20	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.44	0.72	-4.03	21	283	2009-09-11 07:34:40	2003-05-30 11:36:54	7	11	233	15	196	266	1	107.50	27	61.35	CHANGED	LL........p+lcpslpslhspFpcllchAp.............................spssphstssp-shthpscssplVRAs-sLLpLscslKEhhIL................ssh.slscshtppppphctcp.p.sp.ltpLh-chhsslhph	..................................................................p+lcsslpslhpsFppllphAp.............................spssphspspp-saphcsc..ussl...lRAuEsLhpLspclKphhlL................schsslsEs.hpp..pppphctpp..tphpp.l.plhcch..phh.........................................	1	61	104	155
+6008	PF06180	CbiK		Cobalt chelatase (CbiK)	Moxon SJ	anon	Pfam-B_10975 (release 9.0)	Family	This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.52	0.70	-5.30	8	718	2012-10-01 23:23:09	2003-05-30 11:41:05	6	9	587	5	138	730	108	247.40	37	87.61	CHANGED	KAILlVoFGToYp-s+chTI-pIE+clscpFPDY-lh+AFTSshI..I+KLKcR-s............lplsTPtpALp+LtcpGYc-VIVQsLHlIPGcEYEclhchV.........pcapssFccl..clGRPlLth.......s-DYcphlcsl+cphs.h..+sEslVaMGHGosHtususYupLsplhcs.psasslaVusVEuYPsl-sVlcclccpshcc.....VpLhPLMlVAGDHApNDMAuD-p-SWKsthcssGhcV.ps......hlcGLGEhcchpsIalcHI+sslp	............................................................pAlLlVSFGToap-opctsIsuhEcclttsa.P-........hclhcAFTSphI...lc+L.cp+cs...............l.p...l.ssPhpALpcLtppGYpc..VhlQsLHlIsGtE.Y-.c.lh.p.p.V......................p.t...h.....c...s..t.....F.p......c.l....plGp.PL.Ls................p.tp.Da.........pplhpA.l................p.........p....p.........hs.....................h............t...p..........scslVhMGHGo.....p...H...........A...........u..s....Y....u.s.L...c...p.hhps......t.s.h...............p...sa...l....GsV..........E..u...a.P..p...l.....-.p.ll...p.pL..+....p....p......s..l..c.p..................VpLhPhMlVAGDHApND......M............A.........u....-...........-..........t.D..................SWK..st..h..ptt.G..h..p.s...p.s....................hL.p.G.LGE.sslpphalpHlcpAh.t................................................................	0	71	113	129
+6009	PF06181	DUF989		Protein of unknown function (DUF989)	Moxon SJ	anon	Pfam-B_11062 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function. The haem-binding domain towards the C-terminus has been merged into Cytochrome_C, Pfam:PF00034.	22.40	22.40	24.10	23.10	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.09	0.70	-5.34	60	485	2009-01-15 18:05:59	2003-05-30 14:07:51	6	4	442	0	164	459	1793	262.90	44	72.00	CHANGED	Mtu....al...h-WlsLhlRWlHVIsuIAWIGuSFYFlhLDtuLpcsss....hpcGlpGEhWtVHGGGFYHlpKYhlAPspMP.Ec.LHWFKWEuYsTWLSGhALLsllYahsAplYLI...DPs.....hh-L.oshtAlululusLslGWllYDhLC+..SsLGc.......psslLullLallllssuauhsplFoGRAAaLHlGAhhuTIMsuNVFhlIhPsQRtlVAslcuGcsPDPp...hGtpAK.RSsHNNYhTLPVlFlMlSNHYPhsauspaNW.lIlullhlhGshIRHaFNt+Hss.....p.ppshashsusshlhslhhhluss	...............................uhhh-Wlshhl.RWlHVlsuIAWIGuSFYFlhLD..u.Lpp.ss....h.pGs.G-.WtVHGGGFYphpKYhlAPspMP..-cLpWFKWEuYsTWlSGhsLLhllYhhssshYLlD.s.....h.h.sh....u.sh..Altlulu.LshGWllYshlCc........LGp...........psthLhlll.hhhllshuashs.p.....l..FoG.R.AA..a..LtlGAhhuTIMsuNVFhlIhPsQ+tlVu....s...lhs.....GcpPDPt......hG...ctuK.R...ShHNsYhTLPVlFhM.....l.S.N.HYs.hsauspaNW.l.lhsllhlhGshIRpaFsh+..Htt.....p.t..hhshhs.sshhhhhh.hhht.s.............................................	0	34	89	125
+6010	PF06182	ABC2_membrane_6	DUF990;	ABC-2 family transporter protein	Moxon SJ, Eberhardt R	anon	Pfam-B_11079 (release 9.0)	Family	This family acts as the transmembrane domain (TMD) of ABC transporters [1,2]. The family includes proteins responsible for the transport of herbicides [1].	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.43	0.70	-4.81	12	2005	2012-10-03 10:13:34	2003-05-30 14:10:04	6	3	813	0	438	1383	277	223.40	23	87.05	CHANGED	llhhssshhhhhllapp..sssluGWsht-hlhlhGh....hhlhpslhshhhtsshtclscpVccGshDhhLLKPlshhh.lhhcphs.htlhcl.......lhGhhLlsYsshhlslshTshpllhhllsllsGslIhhulhhhhushuFWhhcs.thh.tlhhul...hshupaPhshasthl+hhhsFllPhshhshhPAphhLG+hsh....hhhlhs.hlhullhhslothhWptGlcpYpSsG	......................................................h....hhshhhhtslapp......hs.lp....G......aohpphhhhhhh.........hlsph.l.tp.h.h.h...s...h.h.hhsc..l.+....cGplshhLlRPls........h....hphl...h....pp...h....s.........p...h....l.h.h.l..............hlu..h..l..l.l..h..h..h..h..........t.......h.......s...l..s......h.....s..h...h...p....h.......l..l....a.l....l..sl...hhu..h.l.l.hhtl...plhhu..........hhu.Fah.pp...h...t...u...h...h...h...l...h...hsh...hs.h.uh...h..Plsha.....s.....p....h....lp..hl..l..sa...lPFuh.hsahPsthh...l..s.c.h.ss................hh.s..l.h.h.....hh...hsllh.hslu.hhlWcpulcpaputG.....................................................	0	170	299	381
+6011	PF06183	DinI		DinI-like family	Bateman A	anon	Pfam-B_3085 (release 9.0)	Family	This family of short proteins includes DNA-damage-inducible protein I (DinI) and related proteins. The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co- protease activity of RecA. Escherichia coli DinI, a LexA-regulated SOS gene product, shuts off the initiation of the SOS response when overexpressed in vivo. Biochemical and genetic studies indicated that DinI physically interacts with RecA to inhibit its co-protease activity [1]. The structure of DinI is known [2].	20.30	20.30	20.70	20.40	19.90	18.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.06	0.72	-3.95	11	1722	2009-09-11 10:20:43	2003-05-30 14:12:56	8	2	573	1	94	517	4	64.00	40	80.24	CHANGED	lPsGul-ALpsELp+RlpppaP-..stVpV+tuSusuLSlsGsscc-..KchlpplLpEhWEs.DsWhs	..................hssGAl-ALtsELo.+RlpttaP-..spV.pV+.h.s.uu.ssLolssspc--..KpplpchLpEsWEsADpWhh........	1	1	15	53
+6012	PF06184	Potex_coat		Potexvirus coat protein	Moxon SJ	anon	Pfam-B_11093 (release 9.0)	Family	This family consists of several Potexvirus coat proteins.	25.00	25.00	164.00	163.80	19.80	17.20	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.98	0.71	-4.85	2	45	2009-01-15 18:05:59	2003-05-30 14:13:12	6	1	3	5	0	45	0	148.20	92	83.07	CHANGED	hstRpNRRttSRsutho...DhhYsoLT.tuTToapRpsFPsLtsMGDRsFQVluhpI.ssSAuPhhYpARLYsPtDsDsVtuTGlQh.GTsPRThRhpshsGQNsWF.GNTppspsIlAIDGLhoppusssPpNsVhVphsaRlAPSELQSu	MVGRRNRRQRSRVSQMT...DIMYGSLTLGSTTTWTRKNFPGLANMGDRPFQVISAKIVVSSASPMLYQARLYSPHDDDNVGSTGLQMSGTTPRTHRMRALPGQNTWFSGNTSSTQVIVAIDGLKTKToDVTPQNAVAVQISYRVAPSELQSA....	0	0	0	0
+6013	PF06185	YecM	DUF991; 	YecM protein	Moxon SJ, Bateman A	anon	Pfam-B_11108 (release 9.0)	Family	This family consists of several bacterial YecM proteins of unknown function.	25.00	25.00	44.80	43.70	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.33	0.71	-5.07	6	775	2012-10-02 15:00:03	2003-05-30 14:16:58	7	2	766	1	89	341	6	181.20	59	95.31	CHANGED	spp.shpplhpcLssF.pKIppLuchLsLDLothphDHIALRVNspQoAchhppha.cpGcllS-NhINGRsIhlIcL-pPLphusapI-slELPaPup.KpYPpEGWEHIElVlPupsps...hspchhthhstls.papt.ppsslpVKlSSPKuEGERLsNPTIAhpa.....sssCIKlHPauIKcIlcSE	..........................p.h-ELpDluuDLPRFppAlccLupRLGL......sl.osLpADHISLRCHQNsTAERWR+GFpQCG.ELLS.ENhINGRPICLFKLcEPV.........pVu.......HWp.........hsllELPWPGE.KRYPHEGWEHIEIVLPG..-PET....LsAR..A.LA..LL......oD.............-....G...........L...................o..PGIsVKTSSPKGE+ERLPNPTLAVTD......G+sTIKFHPaSIcpIVASE.........................................	0	11	29	61
+6014	PF06186	DUF992		Protein of unknown function (DUF992)	Moxon SJ	anon	Pfam-B_11128 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.20	21.20	21.60	34.60	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.75	0.71	-4.86	29	199	2009-01-15 18:05:59	2003-05-30 14:18:40	6	1	134	0	76	154	10	145.90	43	86.49	CHANGED	sussuhssssssssspst.lclGsLpCps..suusGallGSsppLsCsFpsp..utss-tYsGslp.+hGLDlGhTppothsWuVhAP..ssphspGsLuGsYsGsuAsAolGlGlGANlLVG.GospuluLQPlSlpuQsGlNlAsGlsplpLp	.........ss.hhshssss.s.usp.spst.sclGhLsCcl..usulGhllGSspclsClF...+spt.sss.-pYsGsIp.KlGlDlGhTspupLuWuVaAP..ssshstGuLsGpYsGAoAsAulGlGhGuNlLsG.GStpoIuLQPlSVQGQpGLNlAsGlssLpLp.......	0	11	33	47
+6015	PF06187	DUF993		Protein of unknown function (DUF993)	Moxon SJ	anon	Pfam-B_11260 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	24.00	24.00	26.20	27.00	21.40	23.70	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.30	0.70	-5.93	21	227	2012-10-03 05:58:16	2003-05-30 14:21:26	6	2	203	1	82	200	28	375.10	58	98.45	CHANGED	ltLPssDGslcsYpLtusshh...tsssuPh.....huRlAaAAAHVVADPhusscPh.ussulDW-uTLAFR+aLWsLGLGVAEAMDTAQRGMGLDWssApELIcRShuEApuh........uup.....lAsGsGTDHLs....PusstsL-sVlsAYcEQlssVEtsGG+lILMASRALAtsA+uPDDYtcVYu+lLspsccPVILHWLG-MFDPALpGYWGSs-hcsAh-TsLslItspusKVDGIKlSLLDps+ElshRcRLPcGVRhYTGDDFNYsELItGDsptaScALLGIFDAIAPAAStALpsLspGDsspa+slL-PTVPLSR+IFcAPTpaYKTGlVFLAWLNGaQsHFpMlGGhpSuRulsHhA-lFRLADpAGLLsDP-lAstRM+tlLult.Gl	.........................lpLPsscuslpsYpLtus.ss...ts...t..ssPt.....hsRlAaAAAHVVuDPhsDssPh.sssAlDW-AThAFR+HLWuLGLGVAEAMDTAQRGMGLsWsuApELIRRShAEA+ss......GAc...........lAsGsGTDHLs......................suts...tsL--VlcAYEEQluhlEptGGRhILMASRALApsA+uPDDYh+VYu+lLuQsccPVlLHWLG-MFDPuLcGYWG.Sp..ch-sAhcTslslIpspssKVDGIKISLLDtc+E...lslRpRLP.......c....GV+hYTGDDFNYsELIt......GDs......p............taSHALLGIFDAlAPtASsAlssLssGDsppF+ull-PTVPLSR+IFcAPTpaYKTGlVFLAWLNGHQsHFsMluGhQSsRulhHhA-lFRLADpAslLscP-LAspRM+pLLAlaGl.............	0	21	52	68
+6016	PF06188	HrpE		HrpE/YscL/FliH and V-type ATPase subunit E	Moxon SJ	anon	Pfam-B_11055 (release 9.0)	Family	This is a prokaryotic family that contains proteins of the FliH and HrpE/YscL family.\	  These proteins are involved in type III secretion, which is the process that drives flagellar biosynthesis and mediates bacterial-eukaryotic interactions [1-2].  This family also V-type ATPase subunit E.     This subunit appears to form a tight interaction with subunit G in the F0 complex [3]. Subunits E and G may act together as stators to prevent certain subunits from rotating with the central rotary element [3].  Pfam:PF01991 also contains V-type ATPase subunit E proteins.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.19	0.71	-4.55	10	187	2012-10-02 21:03:42	2003-05-30 14:28:14	7	1	172	0	31	328	31	164.80	25	79.76	CHANGED	MLs+RpIsLs.ususL.pPllRREpLAsshpAcslLp-ARpQA-plLspAcpcA-thpp....pApApFWppAsuhLpslQpQREplpppsloss-pLLspA.LppLLDETspupRhpALLRQLlsuQhsEusATLhCHPsptssVAcWLsspu.phtWpLpsDsoLssDoL+LsTApGsFslsWsshpctLl	.......................................................................................s...llptt.Ls.p.phpApsl.LppA.+p...QApp...llppAcpc..A.ptlhp......pu..t...p....pA....tp.h....h.......p...............p.....ss...s.h....Lt...t....hp..tp.t....-s.L....p.p....tl........h.p....t.spc....llp..p.u.L...p...plL.c.c.s...s.......t.t......p......h..p.t.L...l.pp...L.....h....tt...................h....l...h..t..s...............................................................................................h...............................................................................................................	0	10	19	26
+6017	PF06189	5-nucleotidase		5'-nucleotidase	Moxon SJ	anon	Pfam-B_10008 (release 9.0)	Family	This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).	20.20	20.20	20.20	30.30	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.69	0.70	-5.58	43	426	2009-01-15 18:05:59	2003-05-30 14:40:48	7	3	318	0	174	428	360	259.30	45	76.67	CHANGED	cYQh-+EspsLpPGsAFPhV++LLulNpthtp.........p.hVEVVLLSRNss-TGLRVFsSIpHYGLs.IoRAsFouGcSPapYlsAasssLFLSustpDVppAlcsGhsAApllsssspssp..............ssp.LRI......................AFDGDAVLFSDEoEplappp.G...LcAFpcpEpppsppPLssGPa+sFLtsLpplQpp...........h....ss..hpsPIRTALVTARuAPAH.ERVI+TLRsWslclDEAhFLGGlsKuphLcsapscIFFDDQpsHl-uAu..ptlsouHVP.aGluNp	........................................pYQhp+Esp.LpPGsAFshV+..................tLLslNpp..htp...........p.hV..EVVLlS..RN.sspoG.l..RlhNSIpHYuLs..IsRusFTuGcuPhs.YlcAatssLFLSussc-VpcAlpt.GhuAAs..lh.ssst...p.t.stt..............ssp.LRl......................AFDGDAVLFSDEoEplappp.G.........LcsFhpaEptptspPLstGPh+sFLpsLscLQpp...h..........sp....psPIRTuLVTARSAPuc.tRsl+TLRpWGlclD.EAhFLGGhsKushLcthpPcIFFDDQhhHl-uAp..ttssuuHVPaGlsp.................	0	31	73	120
+6019	PF06191	DUF995		Protein of unknown function (DUF995)	Finn RD	anon	Pfam-B_11307 (release 9.0)	Family	Family of uncharacterised Proteobacteria proteins.	19.50	19.50	19.60	19.80	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.36	0.71	-4.82	14	170	2009-01-15 18:05:59	2003-05-30 14:50:04	7	4	93	0	32	83	2	145.20	43	80.92	CHANGED	sshlLssulsususstusssss....sApshousElaplYpsKoWhWcs...GAGYFsscsRpFpAWopcssutSaupGRWhlossGpLChcAsW+spsGsusupT.....CFsHRpts.GsIYQ+R-PDGsWYVF++ssspssDEatKLhcuDhVu	.............................................sslLLhussuhAsss.tus...sspct..huspsMoAhcLhpLYts+oWpWsD...GuG..Y...aosK..........c+...pFsAhscpssu+SaupGRWhlTDsG+lChKAtW..psttGs.....s....s.Ap.T.....CFtHRht.D.GslYQ....+.+ps..s.GpWYVFRHsPhQcsDEApKLlpuDhl...............................................	1	2	14	19
+6021	PF06193	Orthopox_A5L		Orthopoxvirus A5L protein-like	Moxon SJ	anon	Pfam-B_10342 (release 9.0)	Family	This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion [1].	22.40	22.40	22.60	22.40	21.30	22.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.23	0.71	-4.31	13	77	2009-01-15 18:05:59	2003-05-30 14:53:24	6	1	37	0	0	67	3	234.50	51	91.58	CHANGED	MDFhsKaSptLspoupsKss...hhhp-Ehssss++spsl-htLKSpEphYQ+QLREQLA+cNMhtssctsI...............................................Ppp.tTNooSshsNl....puDss.spsoSll...p..sulpDIlpcas......................................................................................SVcc-hppLQsEos-LVosltsAREhThcAIspIh.pLsKtFp..phpc	......................MDFFNKFSQGLAESSTPKSS...IYYSEEKD.sDpKKDEAIEIGLKSQESYYQRQLREQLARD.NMhsASRQPIQPLQPTIHITP....................................L.ssosAPTPKPRQ.QTNTSSDMSNLFDWLSsDss.s.sSSLLPALTP.NuVQDIISKFNKDQKTTTsPSTQPSQTLPTTTCTQQSDGsISCTTPTVTP.QP...shsssssTPTssssssssptp.NPGAsSQQNLDsMuLKDLMSsVE+DM+QLQAETNDLVTNVhD.AREY...TRRAIDQIL.QLVKGFE..RFQK.......................................	0	0	0	0
+6022	PF06194	Phage_Orf51		Phage Conserved Open Reading Frame 51	Finn RD	anon	Pfam-B_11352 (release 9.0)	Family	Family of conserved bacteriophage open reading frames.	21.10	21.10	21.10	50.20	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.97	0.72	-3.88	3	378	2009-01-15 18:05:59	2003-05-30 14:54:32	6	1	199	0	3	179	0	75.10	89	98.57	CHANGED	MTD.SssKEYLNQFFGSKRYLYQDNERVAHIHVVNGTYYFHGHIVPGWQGVKKTFDTAEELEsYlKp.HGL+aEEuKQLoLF	....MTD.sARKEYLNQFFGSKRYLYQDNERVAHIHVVNGTYYFHGHIVPGWQGVKKTFDTAEELE.hYIKQ.HGLEYEEQKQLTLF..	1	3	3	3
+6023	PF06195	DUF996		Protein of unknown function (DUF996)	Finn RD	anon	Pfam-B_11375 (release 9.0)	Family	Family of uncharacterised bacterial and archaeal proteins.	26.00	26.00	26.30	26.90	25.30	25.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.86	0.71	-4.18	16	81	2009-01-15 18:05:59	2003-05-30 14:56:10	8	2	55	0	50	89	2	129.20	25	69.88	CHANGED	llullGhVLlLlulttlScths-cclFppaLhuhIhslluhllhhshlh.....huhhhhps.hsshhs.h.hhsh..lhshLushlllallhlluu.......YFh++AactluphoGlshFcpAuhlhaIGAlLhllh.lGhlIllluhI	................lullGhlLlLlulttlucthscpclFpphLhuhIlsll.uhllhhlhhh.................hthhhh.h......h.....h.........h.sh..............hsshlsshllha....lhhllus..........hah++uachluphoGhshFpsuuhhhhhGAlLhlll.lGhllhhluhI................	0	15	24	34
+6024	PF06196	DUF997		Protein of unknown function (DUF997)	Finn RD	anon	Pfam-B_11382 (release 9.0)	Family	Family of predicted bacterial membrane protein with unknown function.	20.70	20.70	21.00	22.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.92	0.72	-4.47	24	837	2009-01-15 18:05:59	2003-05-30 14:58:27	7	1	834	0	88	313	6	75.50	55	89.98	CHANGED	pQApKEAhaAluLsllYhlhWhlhAYh.susss.......hhGFPhWF.hSCIhhPllFhllsahhVKhlF+DlsL-csp.ps	....l.QAHKEARWA..LuLTL.lYLAsWllsAYLP.G.s.u.sG............hTGhPcWFEhACILsPLlFIhLCWhMVKFIa.RDIsLED-D..ut........	1	16	39	63
+6025	PF06197	DUF998		Protein of unknown function (DUF998)	Finn RD	anon	Pfam-B_11425 (release 9.0)	Family	Family of conserved archaeal proteins.	27.00	27.00	27.00	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.46	0.71	-4.98	111	925	2012-10-01 21:22:51	2003-05-30 15:01:43	8	6	680	0	301	768	89	184.90	17	80.56	CHANGED	llusslhhhs..hlhsthhhsua.shhppslS-Lus..........sstsalh..ssuhlhhulhhls..hulhhhh.....ttshttphushlls...lhulu.hhhsG..lastsss.....................hH.hhsuhlsalthslusl....lhu..................hhhthhphhtsluhhhhhsshhhhhhs..................hhGlhpRhhshsh.hsWlhhhuht	...................................h.hsshhhhhs...hhhtt.hh..ts..s.h..s.....hppslStLusht...................ushthha..p.hshllsGh.hhlh..........hshhlhtt................ttph...h.tthss..sh..ls...................hhGlu..hlhsG....lash.sss........................thlH..shs.u....h...l....sh...hshhlshl...........lhs.................h.htt..ht.h..hph.hh.h.lshlhhhhsslhhhst...........................h.h.hGlhpRl.shhhh..hhahhhhs..h............................................	0	104	188	251
+6026	PF06198	DUF999		Protein of unknown function (DUF999)	Finn RD	anon	Pfam-B_11426 (release 9.0)	Family	Family of conserved Schizosaccharomyces pombe proteins with  unknown function.	25.00	25.00	258.50	257.50	19.30	18.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.88	0.71	-4.41	3	9	2009-01-15 18:05:59	2003-05-30 15:35:05	6	1	1	0	9	8	0	141.20	83	55.62	CHANGED	MVEDVCNVDLEQGLDLCKPEKVNKQSQRSRQSRQSLFTNTIKPQKDKMNIKTNKIKEFLNDLFTEFSKFHNSYYPDGRISTRSKhRWPLLIIWSIIIVFAIDKKFEVK-FLSIW.....INENRFYSEIWGPIAIYVCLFVLLLLuLI	MVcDspNVDLEpGL-LCKPEKVNK.........QsLFTNhIKPQKDKhNIKTsKIK.FLNsLFTEFSKFHsShYPDGRISTRSphRWPLLIIWsIlIVFAlDKpFEVpcFLSIW.....INENRFYSEIWsPIAIYlCLhVLhLLuLI	0	9	9	9
+6027	PF06199	Phage_tail_2		Phage major tail protein 2	Finn RD	anon	Pfam-B_11427 (release 9.0)	Family	Characterised members are major tail proteins from various phage, including lactococcal temperate bacteriophage TP901-1.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.45	0.71	-4.10	63	727	2009-01-15 18:05:59	2003-05-30 15:44:01	6	8	629	0	118	479	169	135.50	20	78.71	CHANGED	stpG+Dllltlphsss...s....tatplushpspslshsu-sl-so...op-......s.sthtphlsssGsppsolSusGl.ht.s..s...ssppplcptahsuphsc........apl.................h...hsshu.............p..hpGsah...loul-hu.ustsspsoaslshsusGtlsh	....................................................................pGcDhllhhphsst..t......shhphuh.p.spp.ls.hs.t-ossss....opD.............................thltssGs.hps.o.lSssul..hp.s....c.........stsptlccshhssthh-.........acl.........................t...hssts.................p....hpu.ah.......lsuhphs.ust-shsphphphsssGthp.....................................................................	0	35	76	96
+6028	PF06200	tify	Zim; 	tify domain	Bateman A	anon	Pfam-B_3326 (release 9.0)	Domain	This short possible domain is found in a variety of plant transcription factors that contain GATA domains as well as other motifs. Although previously known as the Zim domain this is now called the tify domain after its most conserved amino acids. TIFY proteins can be further classified into two groups depending on the presence (group I) or absence (group II) of a C2C2-GATA domain. Functional annotation of these proteins is still poor, but several screens revealed a link between TIFY proteins of group II and jasmonic acid-related stress response.	20.90	20.90	22.90	21.50	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.17	0.72	-7.26	0.72	-4.69	48	482	2009-09-14 12:07:42	2003-05-30 15:52:11	9	12	39	0	250	488	0	35.50	41	13.34	CHANGED	ssssssQLTIFYuGpVhVF-slss-..KAptlhplAup	...........stssQLTIFYsGpVhVF.Dslss-..KA.pslhhLAu...............	3	42	154	208
+6029	PF06201	PITH	DUF1000; Thioredox_dimer;	PITH domain	Yeats C	anon	ADDA_10869	Domain	This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.	23.70	23.70	25.60	25.00	22.10	22.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.96	0.71	-4.44	56	613	2012-10-03 19:46:52	2003-05-30 16:00:39	8	18	298	2	434	619	10	146.30	31	56.41	CHANGED	sLhspIDhsplpsLNp.....sss....susttslhcshppc.t...............hlpS.Ds.......D.-QLllpIP..Fss.slKl+Slhl.p..u....................ssspsPpplKlFhN..ppslsF-ssp.shpssQslc.................Lsp.......shpshhphs....L+hs+FpsVpsLolal..........psN.u...s-pT+ItaIslhGps	......................................LhshI-hsplpsL..Nc.......................ssp..........tuht...slhcshp.p......................alcS..D..s........D.EQLllplP..Fss.sVKl+.Slhlpus.........................ssspsP+plKlFh..N..tpshsF-sup...shp....Ps...Qslp..............................Lsp..............shpssh.phs....L+.hs.+Fp.sVps......Lo.lFh................psN.G........t-pT+ltalslhGp...................................	0	153	247	362
+6030	PF06202	GDE_C		Amylo-alpha-1,6-glucosidase 	Bateman A	anon	Pfam-B_3607 (release 9.0)	Family	This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homologue Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.53	0.70	-5.74	14	1196	2012-10-03 02:33:51	2003-05-30 16:24:27	9	30	973	0	546	1693	78	369.30	22	41.39	CHANGED	huospFlscp..........................t.ts.ollAGa.WFu....c.WGRDohIuLsGlhLlsGRa--A+sllhsFuphh+.......+GLIPNthss.sspsh....YNosDAoLWalpulpcYhchssD.hthL....pchaP......................slppIlpsahpGsca....................sltlD.pcuLlhsGs...shTWMD.......AtlsGh.slTPRsGpslEINALWYsAL....+hhpphup.hltc.............tpppYpplApplpssFc+tF...hs.................................................................................scpshlhDslsssp.....pDhplRPN.lhAloL.....s...slhss-pt.thlchspcpLLsPaGL+TLsPcD.sYpGhYsG.sp.sRDtA......YHpGTlWsWllGhalcAhh+hspp...ppt...........ls.hpslLp.h.tal.pushuslsEla-....u-ssasspGChsQAWSVuEllR	...............................................................................................................................................................h.................................hhAGhPaFs.....p..aGRD.s.h.I....u.h.......u..l..h..Lh...s..t......p.....p.............u.c.t.h.l.....h......t.h.s.t..h...t..........................G.h...l.......sp..h..t........t........sp.........t..st...................Y......s....s....s..D..ushaalhs..ltpY...hch....s.s...-....hphl.......pch.h.P..................................................................................................h.lp.p.h...l...p....h...h.......h.....p.....u.....h.p.............................................................p.h.thc.......p.s.....u..h.....l....h....t....s....s....t.....h.........s....ts..W...h...D..................................st....p.s.h....shs.P....c..t..s....t......s....l.E.......l..pu.h.hY.s.A.l.......ph.hu..p.l.s.p..t.h.h.t.t........................................................hstp...h..p..phApplc.p...sF..pc.tF....hs.................................................................................tc..t.s.hh.t...p...h..l.cst.p...........ts.h...p.l.R...s...N.......h.....h.....s....h..s.....l...........................s.........sl.h..s.......c...p.s...t...p...s...l....c..h...h.....p...p...p...L..h..s...s.....h....Gl....R....T..L..ss.................p..................p..h..s..................Y.p...s........................hu......................YHpGshWs...a.huhhhpuhh+.hsh...............................................................hp..h.t..t.hht......h........t..h......t.t......t.........ht...tls.E...l...hs.........ts.s.......s.....h.......h.......s..hus...sQAWusuth..............................................................................................................................................................................................	0	183	334	452
+6031	PF06203	CCT		CCT motif	Bateman A	anon	Pfam-B_314 (release 9.0)	Motif	This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1 [1]. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif [1]. Toc1 mutants have been identified in this region.	20.60	20.60	20.60	20.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.14	0.72	-4.33	42	1411	2012-10-01 19:54:00	2003-05-30 16:45:03	9	19	143	0	549	1397	13	44.30	54	10.78	CHANGED	Rcspl..hRY+-KR+pRpFsKpIRYtsRKthA-pRsRlKGRFs+psp	.............RcApl..hRYREKRKp...R........p..F.....c..K..+....I.....R........Yt....oRKt........hAEpRPRl+.GRFs+ps.s.......	0	133	347	463
+6032	PF06204	CBM_X		Putative carbohydrate binding domain  	Finn RD	anon	Pfam-B_9110 (release 9.0)	Family	\N	21.10	21.10	21.10	21.40	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-9.20	0.72	-4.49	57	1056	2009-01-15 18:05:59	2003-05-30 17:12:43	6	25	595	23	316	973	50	63.10	32	5.20	CHANGED	sshGsFssss+EYl........hhlhss.pT.....PsPWlNlluNspaGhhlSpsGuGYoahpsu+phclT.WpsDsl	........................thGhFsppspEYl................h.sp.ssT.................PtPWsNlLuNs.paushlSssGuG...Yo.a.tss+phplT+acsDss.......	0	99	204	247
+6033	PF06205	GT36_AF		Glycosyltransferase 36 associated family  	Finn RD	anon	Pfam-B_9110 (release 9.0)	Family	\N	21.00	21.00	21.00	21.50	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.82	0.72	-4.24	111	1114	2009-09-11 09:10:52	2003-06-02 09:55:43	6	25	623	23	331	1025	61	89.50	26	7.62	CHANGED	upstas...phspthAah.sss.....tstsuassDRscFlGRstslssPtAl....tpstLSsosGsslDPsuulptplpLtPGcptclsFhlGhupspcp	.......................................p..p.thtp.hsah..sss...............tpssua-sDRppFlGp..s..psh...........ss......PtAl................ttspLos.os..us...shDPsuulp.t.p.l.p.LtPGcptclsFllGhupspp.t.....	0	103	213	259
+6034	PF06206	CpeT	DUF1001; 	CpeT/CpcT family (DUF1001)	Moxon SJ, Bateman A	anon	Pfam-B_11004 (release 9.0)	Family	This family consists of proteins of proteins belonging to the CpeT/CpcT family. These proteins are around 200 amino acids in length.  The proteins contain a conserved motif PYR in the amino terminal half of the protein that may be functionally important. The species distribution of the family is interesting.  So far it is restricted to cyanobacteria, cryptomonads and plants. It has been shown that CpcT encodes a bilin lyase responsible for attachment of phycocyanobilin to the beta subunit of phycocyanin [1].	20.30	20.30	20.40	20.80	19.90	20.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.94	0.71	-4.61	51	207	2009-01-15 18:05:59	2003-06-02 10:29:07	6	2	125	0	80	226	183	162.10	27	83.45	CHANGED	hphschLuGcaoNppQAhcs.......PshaA+IplhaR..PLs.....h.hhpuhuhasEQsYshsstpPYRp+lh+lh.p....sstlhlcNaslc-spcatGAupc.sc..hLpplss-sLphh.pGCs..hhhpppss.t....apGplEPGppChl.R.cGptTYLsSphcl...spp.phhShDRGaDscTccplWGShsG.PacFp+	.......htlsphhsGcasNppQAhps.........P..sh..aspl.clhhc..Pls............h..s......shshahEQ.saths..ppPYR.Rlhclh.s......pspl.lpsYtlcc..p..pahusspc..p........hhptls..p.....plt.h...sCs..hhh.phpsp..s.............apGpspPGptChs.p...pGptoalsophpl....ppp..phhohD+GhD.psspplWGuhtG.sacFp+..........................................	2	18	50	71
+6035	PF06207	DUF1002		Protein of unknown function (DUF1002)	Moxon SJ, Bateman A	anon	Pfam-B_10868 (release 9.0)	Family	This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.	23.80	23.80	25.30	24.90	23.60	22.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.30	0.70	-5.03	47	783	2009-01-15 18:05:59	2003-06-02 10:30:15	6	2	723	0	105	508	7	227.60	38	70.76	CHANGED	LGtsLoppQ..KpphLchh.....s.stsssphlpVTsp-.pcYLsshssp.tphuopshSSuhlphpspG.......pGlpVcs......pNIThVTspMYtNAhlTAGlpcAplhVsAPhtVoGouALTGlhKAaE...us.GpplspcpKpsAs-Elsssupl.......s-shup-csssllsclKc-lscpp..p.....ocp-lppIVpphhpphsls....Lossphspllslhtclpshslsh...sphps....QLsp.lp	.................................LGsuLo-sQ..KppsLctL.....sssc..st...plhTlTssshsKhhs.sss....ss....uhphaSSuhIpphsss.......sGlpVcI.s....cNITpVTpsMYpNAAlTuGlccAcIpVuA...Phs..VoGpuALsGlYtuhE....ss.GtplsppsKclApEELpshSslsttp.......pscss.h.s.s.sKLssAlA-IKptlAKtp.ps.....hTc-Dl+..pIVcc...s....lcshsls......lTssQls.Ilshhhp.lppssl.p....ssshsppLscl....................................	0	32	63	82
+6036	PF06208	BDV_G		Borna disease virus G protein	Moxon SJ	anon	Pfam-B_10516 (release 9.0)	Family	This family consists of Borna disease virus G glycoprotein sequences. Borna disease virus (BDV) infection produces a variety of clinical diseases, from behavioural illnesses to classical fatal encephalitis [1]. G protein is important for viral entry into the host cell [2,3].	25.00	25.00	149.00	148.90	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.66	0.70	-5.58	2	36	2009-01-15 18:05:59	2003-06-02 11:26:44	6	1	6	0	0	36	0	431.60	79	99.96	CHANGED	MQ.SMSFLhGFGTLVLALSApTFDLQGLSCNTDSTPGLIDLEIRRLCHTPTENVlSCEVSYLNHTTISLPAVHTSCLKYHCKTYWGFFGSYSADRlINRYTGTV+GCLNNSAPEDPFECNWFYCCSAITsEICRCSIpNVTVAVQTFPPFMYCSFADCSTVSQQELESGpAhLSDGSTLTYsPY..pSEsVNpTLNGTILCNSSSKIlSFDEFRRSYSLANGSYQSsSINlTChNYTSSCRPRLhRRRRDTQQIEYLlHKLRPTLKDAWEDCEILQSLLLGVFGTGIASASQFLRGWLNHPsIIGYIVNGVGVVWQCHRVNlTFMsWNESTYYPPVDYNGRKYaLNDEGRLQTNTPEARPGLKRVMWFGRYFLGTVGSGVKP+RIRYNKTSHDYHLEEFEASLNMTPQhsIASGHETDPINHAYGTQADLLPYTRSSNhTSTDTGSGWVHIGLPSFAFLNPLGWLRDLLAWAAWLGGVLYLIsLCVSLPASFARRRRLGRWQE	.........MphSMS.LIuFGTLVLuLSApTaslQuLpCNTDSTPuLIDLEIRRLCHssTENVISCEVSYhNHTohpLsAsHsSChKYHCKTYWGFFGSYSsD+lIsRaTGssctClNsS.sEDPF.CNWaYCCSAIss-lCRCSIoNspVuVpoFPPFMYCSFADCSTVSpp-LpsGpAhLSDGShLhasPY.Lpp-VVNpThNGTIhCNuSSKlVSFDtFRRSYuLtNsSYpspSlNlTCsNhoSpCpsR.hRRRRDhpplpYLsHKLRPhLtDAWEDCEILQSLlLGsFGoGhuuASQFLRtWLNHsDIlGYIVNGlGVlWQCpRVNVoFhsWNESTYYPPVDhNGp+haLNDEuRLQTsoPEAhPGLKRVMWaGRhaLGTVsSG.+P+Rl+YN+oSHDYHL-EF-hShNhTPphulAoGHETsPINHAaGTQusLLPYsRSSNlTSTDTGSGWVHIGLPSFAFLNPhGWLRDlhuWAAWLGGlLYLlpLshSLPs.hARRRRLGRWpE.	0	0	0	0
+6037	PF06209	COBRA1		Cofactor of BRCA1 (COBRA1)	Moxon SJ	anon	Pfam-B_11228 (release 9.0)	Family	This family consists of several cofactor of BRCA1 (COBRA1) like proteins. It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfolding. BRCA1 mutations that enhance chromatin unfolding also increase its affinity for, and recruitment of, COBRA1. It is thought that that reorganisation of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions [1].	18.70	18.70	19.20	19.70	17.70	18.60	hmmbuild  -o /dev/null HMM SEED	475	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.56	0.70	-5.89	6	144	2009-01-15 18:05:59	2003-06-02 11:29:37	8	8	89	0	96	136	2	349.50	39	69.02	CHANGED	MPSlQPVVMsVhKHLPKVPEKKLKlVMuDKELY+sCAVEVKRQIWQDNQALFGDEVSPLLKQYIlEKEssLFSo-lSlLHsFFSPSPKTRRQGEVVQKLTpMIGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDlsEICoVDPCHKFTWCLDACIREKFVDuKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLAhSslRpLQELlup-uLPRDSsDLhLLLRhLuLGpGAWDMIDSQVFKEP+lD...sEllT+FLPhlMSlhVDDpsFNl-sKLPs-EKpsshh....PssLP-sFp...................................+FlpENRVACElGLYYsLHIsKQRNKNALhRLLPuLV-shsDhAFsDIFLHLLTupLsLLuDEFusEDFCoulFDsFLLTuhopKENVHRHsLRLLhHLHpKVsPs+lEsLhKuLEPspQpsEsl+ELYspLt-Klps...p+ssPssp.-ssuh-.sLtuVsssssh	.......................plpPVVMtlh+ph...c...ls-+hL......chlhtDc-LYpsssh-VKRQIWpsNpuLFuDEVuPLLppYIhE.......KEthL.hs....phs...p..........FF.t..s...PKsR.R..Q..up..l.l.+LspMlG.psl+LYDhlLQF....LR...TLFl+T+NlH....YCTLRAELLMuLHDh-lt....-IhshDPCHK.........FsWCLDACIR-+.VD.KRsRELQuFL-.sl.K+Gp.EpVLGDLSMlLsDPaAhNhLshSsl+.Lpc..Ll.s.p-.sLPR-s...Lh.LLLRhLuLG...uA..WpMI.-oQsF.KE.P+h-...hpllspFLPhhhuhh...l-D.h.hp.l.pt....+L..ss-c+tsh.h....ssshs.-....sh....................................................tal.....pppthup..luhaYhl+h......h......p.+.....sp.....s..l..+lL.shLsp..shs.c..hu.h.t.D..FL..H..lhs.Lh.....h..s-...ch...s....cp.hs.p.lh-tF.hhts.s.ppssp+H......hL+hlhhla.+..l....shhtt.l.ct.hpP.tt.....t........p..t.h.thh......................................h......................................................................................................................	0	47	56	76
+6038	PF06210	DUF1003		Protein of unknown function (DUF1003)	Moxon SJ	anon	Pfam-B_10814 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	24.60	24.60	27.40	24.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.48	0.72	-4.13	71	827	2009-01-15 18:05:59	2003-06-02 11:31:43	6	4	766	0	249	630	135	107.60	40	53.07	CHANGED	sGShtFllhasshlslWlslNshhhht..ht.................................FDPYP..FILLNLhLSh.AAhtAPlIhhuQNRQss+DRlpucpDhplNl+uEhElphLtcclstlttp.tphhtctpphpt	............hGohpFllhhslllssWlllNh..hshht....hp.................................FDPYP..FILLN...LhhSs.AAhtAPlIhhuQNRQ-cR.D..RlpsppDhcl....shpuct-hchLtcclstlthp.t-hhsc...hp.p.................................	0	81	162	212
+6039	PF06211	BAMBI		BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain	Moxon SJ	anon	Pfam-B_11792 (release 9.0)	Domain	This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling [1].	19.00	19.00	20.20	19.70	18.30	17.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.62	0.72	-4.05	4	68	2012-10-03 01:43:02	2003-06-02 12:43:19	7	2	50	0	36	72	0	100.80	68	38.57	CHANGED	puSLlSlWLQLELCAMAlLLTKGEIRCYCDAPHCVATGYMCKSELNACFT+lLDPQNoNSPLTHGClDSLhsos-sCpucsscs+otsosP...LECCHEDMCNYRGLHD	..............sshh.lWLQLELCAMAl.LL..TK.GE...IRCY.CDAsHCVATG...YMCKSELs.ACFSRLL..DP..Q.N....oNS.P...LT.HGCLDSl....AS....T..u.DlCpA+Q..ApNHS...G....o.shP.........oLECCHEDMCNYRGLHD......	0	7	11	20
+6040	PF06212	GRIM-19		GRIM-19 protein	Moxon SJ	anon	Pfam-B_10760 (release 9.0)	Family	This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-ß and RA. A bovine homologue of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localisation and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity [1]. 	25.00	25.00	25.20	27.90	20.70	24.60	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.63	0.71	-4.44	11	296	2009-01-15 18:05:59	2003-06-02 13:27:30	7	4	250	0	189	281	4	119.70	37	86.33	CHANGED	suu.sK.QDhPPPGGYtslsa+RshPKpshSGauMFAshhGhhsaGhathhpts+Ec+R.pIE.hsARhAlhPlLpAE+DRcaL+.L++Nh-EEAclMKDVPGWKV....GEsVF+T...-+WVsPhhpEhYshpsh-	.................s.....h.QDhPPsGGY.tslpY+Rs.lP.p.+G.hs.........uhshhsshhuhhsaGaaplhps.s+cp.c.c......L.thEchtuRlsLhPlLQAEcDRc.hl.+phppshpcEtp.l..McsV...sWcs........................sp....pVapo...s+ah.Ph...........t.......................................	1	68	106	154
+6041	PF06213	CobT		Cobalamin biosynthesis protein CobT	Moxon SJ	anon	Pfam-B_10956 (release 9.0)	Family	This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid [1]. 	23.00	23.00	23.10	23.70	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.76	0.70	-5.27	6	469	2009-09-11 12:48:28	2003-06-02 13:36:36	7	7	445	0	122	386	1322	275.30	25	44.87	CHANGED	+soss.sssEPFKRAlssClRuIAGst-lEVuFus-RPuLsusR......ARLP-lP++sopp-hAlsRGLuDSMAL+hApHDP+lHu+htPpGt.sARAlF-AVEQARVEAIGApsMsGVAcNL...ouML-DKYpKushscl..ss+uDAPlEEALuLhVRE+LTGcssPpu...........AcplV-LWRsalEpKAutDlcpLuusl-DQpAFARlVRDMLuu.....................h-hAEEhGD-pspsDpE-s..D.-DsPpp-pp--pus-EppGs-s...u.uc-...u-uos--tEpu-hEuu-uos-DhsD-sDt	.......................................................................................................t.........pshKpAlstss+AlutchplcVsa.....ss....s....ps...t..h....supp.........hcL..P....p..h.s.cc.hs..tp.ch..s..hs..RGhuDuhAL+ltapDsplHtpht.Ppss....ARsl......a-AlEpsRlEulGucths.GsupNL...sshl..p...p..c.hpcs.p.hs..ph..pscs.s..usL.ttu...l..uhh...l...R....p+loGps.s.Pss.....................stpll-....L....hRph.....l..pp....puusp....Ls.sLt.......ps..l.p......DQt.......u...FA.......c.hs...+c..hlss....................................h..p.h..s.....p..c....u..p.c..p..p...s...-....p..pps......p...ppps.p....p.p.......p...p.pp.t...u..s.p..p.p...ps.ssp..........s.s.pp.........spss..p.p.....p..t....p..p...tt..pt..s..p.t.t.......................................................................................	1	33	78	95
+6042	PF06214	SLAM		Signaling lymphocytic activation molecule (SLAM) protein	Moxon SJ	anon	Pfam-B_11112 (release 9.0)	Family	This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones [1]. SLAM has also been recognised as a receptor for measles virus [2].	25.00	25.00	25.30	79.80	23.00	21.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.65	0.71	-4.19	4	58	2009-01-15 18:05:59	2003-06-02 13:48:11	6	1	36	6	14	52	0	122.10	64	38.47	CHANGED	MDPKGhLShphLLhLSLAhcLShGTGtulMsCPc.ILtpLGSslhLPLssE.pIsKSMNKSIHILVTMAcSPtsolcKKIVSLDLscGusPRaLpDGY+FaLENLoL+ILcSR+EsEGWYhhoLEENV	....................MDPKG.LLSLshlLFLSLAFchShGTGtshMNCPc.IltpLGSslLLPLTpE.tIsKSMNKSIHIlVTMAcS.tsSVc+KIVSLD.sEuGsPRYLcDtY+FaLENLoLtILESRKEcEGWYhMTLEcNl..	0	1	1	1
+6043	PF06215	ISAV_HA		Infectious salmon anaemia virus haemagglutinin	Moxon SJ	anon	Pfam-B_11275 (release 9.0)	Family	This family consists of several infectious salmon anaemia virus haemagglutinin proteins. Infectious salmon anaemia virus (ISAV), an orthomyxovirus-like virus, is an important fish pathogen in marine aquaculture [1].  	19.60	19.60	20.80	22.90	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.43	0.70	-6.16	3	464	2009-01-15 18:05:59	2003-06-02 13:54:06	6	2	3	0	0	388	0	318.40	88	99.80	CHANGED	MARFIILFLLLAPVYSRLCLRNYPDTTWIGDSRSDQSRVNPQSLDLVTEFKGVLQAKNGNGLLKQMSGRFPSDWYTPTTKYRILYLGTNDCTDGPTDMIIPTSMTLDNAARELYLGACRGDVRVTPTFVGAAIVGLVGRTDAlTGFSVKVLTFSSPTIVVVGLNGMSGIYKVCIAATSGNVGGVsLINGCGYFNTPLRFDNFQGQIYVSDTFEVRGTKNKCVLLRSSS-sPLCSHIMRNVELDEYVDTPNTGGVYPSDGFDSLHGSASVRTFLTDALTCPDIDWSRIDAASCEYDSCPKMVKDFDQTSLGNTDTLIMREVALHKEMIuKLQRNITDVKsRVDAIPP...NIFISMGVAGFGIALFLAGWKACIWIAAFMYKSRGRIPPSNLSVA	.......................RLCLRNaPDTTWlGDSRSDQSRVNPQSLDLVTEFKGVLQAKNGNGLLKQMSGRFPSDWYTPTTKYRILYL....GTNDCTDGPTDMIIPTSMTLDNAARELYLGACRGDVRVTPTFVGAAIVGLVGRTDAITGFSVKVLTFsSPTIVVVGLNGMSGIYKVCIAATSGNVG..G..VTLINGCGYF...NTPLRFDNFQGQIYVSDTFEVRGTKNKCVLLRSSSDTPLCSHIMRN.VELDEYVDTPNT.GGVYPSDGF.DS.LHGSAS...VRTF..LTDAL...TCPDIDWSRIDAASCEYDSCPKMVKDFDQTSLGNTDTLIMREVALHKEMISKLQRNITDVKh....R.V..-Ah.s....................NIF.....IS.MGVAGFGIALFLAGWKACIWIAAFMYKSRGR........................	0	0	0	0
+6044	PF06216	RTBV_P46		Rice tungro bacilliform virus P46 protein	Moxon SJ	anon	Pfam-B_11281 (release 9.0)	Family	This family consists of several Rice tungro bacilliform virus P46 proteins. The function of this family is unknown.	25.60	25.60	25.60	793.10	24.80	25.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.33	0.70	-5.62	2	12	2009-01-15 18:05:59	2003-06-02 13:59:52	6	1	2	0	0	13	0	388.60	77	100.00	CHANGED	hNhEhPYSIHhlsKN+VPIYcQGNLFHoEhouRLSHlSpGLlDHLFTF.SDNTERVRKLHllu-alY.hE.EhpoYp.Eh.pLp-QVSpLp.pspp.+tpltp.+-hlEGLREPlKKPIYTTQDKEtLRsFFCcERSMEYIYaHIKRLAppSYYSHLNKLQKDhE.hRGhYhSFLTNVKFLVLhEsGhWTs.sIEsp.hspS.L.loQccGEc.hpKGll.hN.E.EuG.Y.LostFluDLYAHGFIKQINFTsKlPEGlP.lItEKl.pYKFPGuNTlLIE+EIP+WsFs.MKRpTphRTplYIhpsaRsFYGaSPl+sYEPITPEEFGh-YYSWEphhE-Dct-VVY.ShsT+..KVs+E..aAWPpcDuDhMSCoTShtEEahHRht.A	hNhEhPYSIHhlsKN+VPIYcQGNLFHoEhouRLSHlSpGLlDHLFTF.SDNTERVRKLHllu-aLY.hE.EhpoYp.Eh.pLp-QVShLp+pspp.Rtpltp.K-hIEGLREPlKKPIYTTQDKEtLRsFFCcERSMEYIYaHIKRLAppSYYSHLNKLQKDhE.hRGhYhSFLTNVKFLVLhEsGhWTs.sIEop.hspS.L.loQccGEc.lpKGll.hN.E.EuG.Y.LostFluDLYAHGFIKQINFTsKlPEGlP.lItEKl.pYKFPGuNTlLIEREIP+WsFs.MKRpTphRTplYIhpsaRsFYGaSPl+sYEPITPEEFGh-YYSWEphh-EDEu-VVY.ShsT+I.KVsRE..aAWPpcDuDhMSCTTShE-EahHRh-...	0	0	0	0
+6045	PF06217	GAGA_bind	DUF1004; 	GAGA binding protein-like family	Moxon SJ, Bateman A	anon	Pfam-B_10604 (release 9.0)	Domain	This family includes gbp a protein from Soybean that binds to GAGA element dinucleotide repeat DNA [1]. It seems likely that the this domain mediates DNA binding. This putative domain contains several conserved cysteines and a histidine suggesting this may be a zinc-binding DNA interaction domain.	26.10	26.10	26.20	34.20	23.80	26.00	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.28	0.70	-4.45	10	153	2009-09-12 21:59:08	2003-06-02 14:01:58	7	3	38	0	65	172	2	273.70	39	97.75	CHANGED	MDscGh....Rphu.aac..............Ps..sshK.phuhQLMSols..-RDst............+-pNl.httppuuh.........tpRD.........................Mua..pDsWlsp.........+Dsthhsh..hpss............s..hthlsso+shcphQ...pp......pht-sshs.h.c.c...s.PlspssssspcstpspttppspsPKssKsc..KsK+tsssspcpsstss....c...............................sKss+Ksh-l.sINtVuhDhSslPsPlCSCTGsspQCYKWGsGGWQSACCTTslShYPLPhsTpRRGARluGRKMStGAFpKlLp+LAuEG.aDLSNPlDLKsHWAKHGTNKFVTIR	..........................................................MDsss.......Rphs.....ac...............................hh.......hplMu..hs..-Rsst..............pcts..h..h.ttptuh.........ttRD.............................hsh..R-shlsp............pcpthhsh..hpps........................................ht.h.....ts.pph.pt.p..................................ht.tsshs.......c..p.......t.s..l.p.p...ss..t.tp...s.t..s.K...p.p....ppsp.psK.s.psp....+sp+....sthspcpsp.ps....c...................................................s+ssh..Ks...-...l.sl..Nt....lshD..SshPsPVCSCTGsspQCY+WGsGGWQSACCTTslShYPLPhssp+RtARluGRKMStGAFpKlLp+LAuEG.aslusPlDLKsaWAKHGTN+alTI+............	0	8	43	52
+6046	PF06218	NPR2		Nitrogen permease regulator 2	Finn RD	anon	Pfam-B_11335 (release 9.0)	Family	This family of regulators are involved in post-translational control  of  nitrogen permease.	27.50	27.50	29.50	28.60	26.90	27.30	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.37	0.70	-5.78	16	363	2012-10-01 20:21:22	2003-06-02 14:04:55	6	7	244	0	279	366	2	293.80	27	83.34	CHANGED	GF.P.IpsIFYohFHPTpGoKlhaQsPsssl.................tsshhsFDol+sYlIPKPpLCNKLlTlp..hscY+llGYPVsI.psscYuRNuF.FNhsFVFsh-.scossYEssl+RLG+hhplLEEQophLSct-p..s.h....................................................................st.pIpsLlpplapDLNNYuEChIPlDsuNoIsIKLFPlhPsPss.lpsapVPIhslpLpsllD.sNWD.TMhKIlPaINGlNSlt+IucLADs-hpLs+pCIQHLlYYsCltllDIFQFSNIYAPTsplpsFlpss.shucECQsYVhssssp.............................st.t..s......................................................................plPopssLFpLYpSLsQGpTlK-Whtpphpt....l..ssIDlRRhIpFGll+ulIYRlapYPl....hsshs.......sptcchhph.tp......................hDclssctshs.tslpct..............pslhc	.......................................................h.....l.slhhs.F...................G...shl.hp.P.t.l......................................................................................................Fsshp.alIs+.thptp..h..lphp.............thpl..l..uhP..l.h..t..p....p.......Yt..RN.....t........h.F..NhshVht.p....p...............s.............h.....c......hlp+.huthhh..hE.p.sthlSp......t...........................................................................................................................................t......l..l....h..lhp-L.....N..t.........t....shl.l......sp....s..slplKlh........h.........sPs...h...p......pVPl....h..p...h..t.......th..t....pWD.Th.pllsaIsGhppltpIu...upsp.tLsh.s..lppLhaYtsl...........l...hshh.aush.....Yh..p.....h.....tp.h...h.t........s................h.p...tC.tal.....................................................................................................................................................................................................................................l..hthh.tth..p.............u......shtphh................lD.R+hl.FGl.cthlhph.pash......................................................................................................................................................................................	0	108	156	235
+6047	PF06219	DUF1005		Protein of unknown function (DUF1005)	Finn RD	anon	Pfam-B_11366 (release 9.0)	Family	Family of plant proteins with undetermined function.	20.40	20.40	32.60	24.80	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	460	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.60	0.70	-5.82	9	119	2009-01-15 18:05:59	2003-06-02 14:07:22	7	3	18	0	76	127	0	316.70	42	96.87	CHANGED	MDPCsFVRlhVGsLuL+h.......ssssspsssussc.ps...sChCcI+l+sFPhQhsslPLlshs-ups.......ssspolAAsFaLscu-lctlhp+spah..........usLclsVYs........GR+GssCGV..suut+LlG+hplslDLcuu...-uKsslhHNGWlslGppptpp.ts....sAELHLpV+sEPDPRFVFQFDGEPECSPQVlQlQGshKQPlFoCKFupcpsu..ps.p............t.W..ouhso-p..-ptu+ERKGWplTlHDLSGSPVAhASMlTPFVsSPGoDRVoRSNPGAWLILRPsGst...........oWcPWGRLEAWRERG....hpDoLGYRF-Ll.-G....usulshAEooIS.uc+GGcFsIDh.tt......ssh.s.ttphphuuhustuuus..tss.t....................GFVMSupVpGEGKsSKPhVcVuspHVTCsEDAAhFVALAAAVDLShDACRLFs++LR+ELpp	...................................MDPpsFlRl.lstLul+hP..............................t..t...s...sC..Cpl+l.th....P......p......s.hPhh...t.............ts.ussF.Lststlphh.t..s...................Lpl.las........G..u......t..t.....CGh......ttphlGhhpl.ls..ths....ucs..hhhasGWhsluptt............tsphpl.V+hEsDPRalFpFss-sthuP.lhQl.....p......G......s.....h+QPhFoCK...Fuhcp.s................................t.....tt.t+E.RKGW.lhlHDLSGSsVAhA.MsTPFVsSs.GsspVuRSNPGuWLIlRP.uss.............oWpPWGRLEsWREc.G...........D.slsh+hcLl...s.......sssl.hu-ssls.sppGGpFsIDh..............................................................t..GFVMustV.pGEu.+sS..+.Ph.VpluhtHVsChtDAAhFhALuAAlDLSh-AC+.Fpp+hR+chp.........................	0	10	47	64
+6048	PF06220	zf-U1	zf-U1; U1_C; 	U1 zinc finger	Moxon SJ	anon	Pfam-B_10606 (release 9.0)	Domain	This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly.  Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilise U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator [1]. This domain is probably a zinc-binding.  It is found in multiple copies in some members of the family.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.08	0.72	-4.39	11	661	2012-10-03 11:22:52	2003-06-02 14:07:45	7	17	296	1	456	687	10	36.70	41	15.13	CHANGED	MP+YYCDYCcsaLTHDo.SVRKtHsuG+pHtpslpcYY	.........+.aaCDYCcsalscDosSlRKpHpsGppHpcNVpca......	0	152	235	353
+6049	PF06221	zf-C2HC5	Zf-C2HC5; 	Putative zinc finger motif, C2HC5-type	Finn RD	anon	Pfam-B_11300 (release 9.0)	Domain	This zinc finger appears to be common in activating signal  cointegrator 1/thyroid receptor interacting protein 4.	24.30	24.30	25.20	25.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.67	0.72	-4.21	33	300	2009-01-15 18:05:59	2003-06-02 14:20:43	8	6	263	0	212	293	1	53.90	44	10.63	CHANGED	s+ptCsCtAppHsL......ssNCLsCGKIlCspEG.......sPCsFCG.sslhs.....sppppplhpt	.....s.p+.CsC.ApcH.L......hsNCLsCG+IlCppEG.......GPCh.FCG..s.lho.....pp-.p.h...p............	0	72	119	178
+6050	PF06222	Phage_TAC		Phage tail assembly chaperone	Finn RD	anon	Pfam-B_11379 (release 9.0)	Family	\N	25.00	25.00	39.10	39.10	22.10	19.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.56	0.71	-4.59	6	219	2009-01-15 18:05:59	2003-06-02 14:27:42	6	2	157	2	7	135	0	121.60	75	96.51	CHANGED	hspsLRslALsshuGaRHKT.VsVPEW-GspVsLREPSuEAWhhWpEll+...G.ucDD-s.loVsEKhpR.....NhpADVpLFlDVLhDpshQ...RVFS-DDppQVttlYGPVHuRLLppALEL....lsssE-A+K.	.......MtKDLKTLALARLSGFRHKT.VKVPEWtNVSVVLREPSAEAWYLWQEVLN.........G.DGE.DDDT.LSVVAKTRR.....NLEADVTLFCDVLCDTDLQ...RVFoPDDREQVLAVYGPVHARLLRQALEL....IADAESARKK...................................	0	0	1	5
+6051	PF06223	Phage_tail_T		Minor tail protein T	Finn RD	anon	Pfam-B_8084 (release 9.0)	Family	Minor tail protein T is located at the distal end and is involved in the assembly of the initiator complex for tail polymerisation [1].	25.00	25.00	26.20	25.00	24.10	23.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.37	0.72	-3.61	4	777	2009-01-15 18:05:59	2003-06-02 14:39:43	7	2	329	0	11	264	0	96.40	61	80.47	CHANGED	+LAREFRRPDWRpMLuEMSATELGEWu-aFsppSFSDsLLDAcFAoLKuLlsuLVoGsscsA.tDFSLLscpEuh.E+TD-ELMpLGEGIoGGVRYGPDSpPG	..........htRsDWRtMLAGMoSTEYADW++FYpTHYFpDs.LDMHFS...GLpYsVLSLFF.u..DPDM.HP....uDF..SLL..s...c.c..E....u.....p.E....h..E....D..-h..LMQKAAGLAGGVRF.GsDG.............	0	0	1	5
+6052	PF06224	HTH_42	DUF1006;	Winged helix DNA-binding domain	Finn RD, Bateman A, Eberhardt R	anon	Pfam-B_8424 (release 9.0)	Family	This family contains two copies of a winged helix domain.	24.00	24.00	24.00	24.40	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-12.14	0.70	-5.10	119	1653	2012-10-04 14:01:12	\N	7	6	1193	0	494	1415	196	321.90	24	76.36	CHANGED	lccLsslQhss....spstahsLauRls.sa...psstLpph.......hpc+plhchashcuo..ll.shc-h.hhphthtshhttt....t...............hphhstphpph.hstlhptl..tspuPloss-lttthttp...............tht....sspthhp.hlhhpG.lshsshp.uh.........phashs-ch...........................................................................................................................................ppps.....hctLlpchlpuhG.sAoss-lttaht..ls.t.....ps+tslt..thhtttcL.hthplc.....t.t....hashs...........s.....sthsssss.......h........plLssFDshlhs+pc..ppclh.s..hta+hcla.sss.sph.........shslLhsGpllGphchcsc..cps......usLplps...h...hscs.......................tts...slttphpchupa	..............................................................................................................lp+huhlQhss....s+usalsLauRls..sa........s.p..hL-cu..........htct..clhch.Wupcus..hh.Ptp.Dahh.hc.t..thhs.tphs......hhh...........................tshh.p.ptpt..htp...llptl...psc.G...P...........l..pus-hppthttt.....................th.h.php.........st+p.........h.....L-..tL........h..ts.........G.cl.........hsst.+.p..shp.........................+sYcL..sc+l...............h....Pp........tps..............................................................................pscu.........hthhlcphhcuhG..ss.......t.p....plssa..hp....Lphs.......shps.h..hp.....thht.t.t.pl..lsVp.l-.................t.ht....hahps..................................................c............tth.stt.ss.........s.......tlLuPFDsl.lhs+c+....tppLa.s.hpa+hEs.a.sssspp.............shslLhpGpllGph-h+hc..+pt..........shLplhs........hhhpt.....................htt...sltpthpphAta..................................................................................................	1	183	350	445
+6054	PF06226	DUF1007		Protein of unknown function (DUF1007)	Finn RD	anon	Pfam-B_8585 (release 9.0)	Family	Family of conserved bacterial proteins with unknown function.	21.00	21.00	22.00	21.90	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.44	0.70	-4.59	46	668	2009-01-15 18:05:59	2003-06-02 14:57:21	8	5	643	0	141	463	41	197.50	28	83.76	CHANGED	pthtlhhuslssh.........sAtAHPHsal-hpspllhssss..lsul+htWpFD-haSuhll...thcpspcuphsp..pcLpplupsshpsltphpYFThlh.ssGcpl+as.p.....................Ps........chthshcs....s........plhltFslsLsp.Phshp.tt......lslpsYDPoYalshsasp.c..sslplssts.tsCphplhpPsssss...........tpuLshspts......ssshGthFAp+lplpC	..................................tt...hhhshhshh.......uhAHPHsFlchpspllhcspt..lsulchpWphD-hhSuslLh........cs.tsut.ss.cthpcLutpl.h.ssl.hs..p+Y...FTplh....t..s...Gp..p..lKhp..p.....................Ps..............phthshcs.....p................................plllpFsl.sLsc.P.sls..sps......hshssaDPoYYlshpYsp...c.......sslshs..s......ttCphplhpPpsstt.h.........tht...toL.sptt.ts.......s.slGp.FApplplpC...............................................	0	29	75	108
+6055	PF06227	Poxvirus	Orthopox_N1;	dsDNA Poxvirus	Moxon SJ	anon	Pfam-B_10619 (release 9.0)	Family	This is a family of dsDNA viruses, with no RNA stage, Poxvirus proteins.	21.10	21.10	21.20	21.80	20.00	21.00	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.21	0.71	-4.71	37	475	2009-01-15 18:05:59	2003-06-02 15:01:29	7	1	40	23	1	377	0	156.50	20	92.13	CHANGED	M...............................................sp.s.............................................................hphsahhtsphs.tpcslpsllpcYhhaRsh....hhtppphG+lFpcLhpaDp.Ahpha...G.slp.....phhpshh..s.......hpshphhhphphshp.......hhpsptlIGlhuhluchhs.........thhslh.hhhphls.pphpp	.............................h......................................................................................................pashtcphs...p.sslpsllp-Ylhapsp.....t.p.shGpla+plhoacp.Ahcha...u.slp...............plhpph..................hpshs.al+hhhshs.......h.pspshIGlsuhlschhs.........phhpshhhhhph.l.s...h..t........................	0	0	0	1
+6056	PF06228	ChuX_HutX	DUF1008;	Haem utilisation ChuX/HutX	Moxon SJ, Bateman A, Eberhardt R	anon	Pfam-B_10620 (release 9.0)	Domain	This family is found within haem utilisation operons. It has a similar structure to that of Pfam:PF05171. Pfam:PF05171 usually occurs as a duplicated domain, but this domain occurs as a single domain and forms a dimer. The organisation of the dimer is very similar to that of the duplicated Pfam:PF05171 domains [1,2]. It binds haem via conserved histidines [2].	25.00	25.00	25.00	25.90	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.47	0.71	-4.80	38	458	2012-10-01 19:49:10	2003-06-02 15:03:01	8	6	445	9	79	1005	54	137.40	45	67.28	CHANGED	lApcLsloEh-VlpALPtchsshhsu..sphpplLpslspWGp.VTsIl+stsuIaEh+ushPpGc.hu+GYaNL......htppst..LcGHL+h-shstluhVs+PFh.Gpc...otSltFFsppGcslFKlYLGRDc.pRpLhspQlptFcsLt	..........................lAcphsso.h-VVc.sLP.pp..........h.s.h.s.sG........s+hsslh.-.s.l.s.c.WGs..VTTlV+os.ssIhEhpGt.lPp....G......p......h......u....+.......G....Ya...NL.........hu+cG....lpGHlKh-NsspIALlp+sFM..Gh-............otSltFFsppGp.shFKIaL.GR..D.-...+RpLhs-QVstF+sL........................................	0	14	41	60
+6057	PF06229	FRG1		FRG1-like family	Finn RD	anon	Pfam-B_8590 (release 9.0)	Family	The human FRG1 gene maps to human chromosome 4q35 and has been identified   as a candidate for facioscapulohumeral muscular dystrophy.  Currently, the function of FRG1 is unknown [1].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.13	0.71	-4.84	13	253	2012-10-02 19:42:32	2003-06-02 15:04:21	7	11	189	1	166	289	1	170.60	35	65.39	CHANGED	uSYlcAhssGhhThGtPHcs.spsPsPcElFsAs+l.u-p+luhKoGaGKYLuls..scGlloupu-AIuspEQaps...........lFpss+sAhhu..............ssssFlSssp.tp..h.upS+psupsEhlclRucssp.......shpsphclthpsRhcs+.pt.p.lKthQ....chpc+cL......RLsc--s+cLK+ARc-GshHEslLDhRsKhKsD+Y	...................................................lpshspG..shutPHp............................p.asAs+.l...u.sp...p...lu.hKo.u..a..G+YLu..hs..pp..G..l..lsupo-AlushEpaps.....................................lh.p....s....s..p..hAhhu.............................................ssssFlsssp..st....h.upuc...su....up....p-..hlclRusApc..................phppp..cl...p.s.+....t....ps..+tp..php.s..Kthp..........phpc+cL...................+l..scc-s..+hLK+A++-GphHEtLLDhRsK.hKtD+a........................................................	0	58	83	127
+6058	PF06230	DUF1009		Protein of unknown function (DUF1009)	Finn RD	anon	Pfam-B_8705 (release 9.0)	Family	Family of uncharacterised bacterial proteins.	25.00	25.00	57.40	31.60	21.60	24.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.07	0.70	-11.13	0.70	-4.97	83	491	2009-01-15 18:05:59	2003-06-02 15:08:55	6	4	486	0	172	434	1229	213.30	35	75.92	CHANGED	lGpllchL+ppGlscllhsGsl.pRPth.sslc......Dhpslpllsthh..uh.ptGDDuLL+ulhphhEp.pGhplluuc-lhscLLs.spGsLsptpPspppppDlthGhplspslGshDlGQusVVpsGtVlAlEuhEGTDshLtR..................supLst...........ttsuVLlKssKPsQDhRhDLPslGspTlcssscAGlsGlulEAGpslllDpptslptA-ctGlhlhu	..............Gcllchh+ppslscllhhGsV.pR.P.th..ps...l.p.......Dhtshplls.h....tl..spGDDsLLpullshlEp.pGhcVlusp-lhssLls..s.sGsloctpPssp-ppDIphGhchAptLu.tlDlGQusVVpsGtVlAlEu.hEGTDthlpR...................................sucLtp................puuVLVKhsKPtQDhRhDlPsIG.pTlcshtcuGhsGlAlEAG+slll-.p.pcslthAsctGlFlh........	0	74	121	142
+6059	PF06231	DUF1010		Protein of unknown function (DUF1010)	Finn RD	anon	Pfam-B_11467 (release 9.0)	Family	Family of plasmid encoded proteins with unknown function.	25.00	25.00	27.80	28.00	16.80	15.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.90	0.72	-3.98	8	110	2009-01-15 18:05:59	2003-06-02 15:14:07	6	3	46	0	6	54	0	88.70	68	92.27	CHANGED	MpAtoYSSAhPCS..................+GFpsFLASSACsASATSYaSCSAAPLpWPSAFSWAAPhhKAGRSlLAFGSN...sAlK.....P......TRlhRuAYLuR	.........................QTAFSFSuslQphhChFSG......LRLhuLRtFsVFLASSPCVASASSYtFCSAVPPRW+SsFSpLAPVAKh+LSVLASGSN...ISVK.....P......TRILRSAYLuR................................	0	0	4	5
+6060	PF06232	ATS3		Embryo-specific protein 3, (ATS3)	Finn RD	anon	Pfam-B_11504 (release 9.0)	Family	Family of plant seed-specific proteins.	20.90	20.90	21.00	21.10	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.82	0.71	-4.54	15	103	2012-10-02 11:40:54	2003-06-02 15:18:41	6	3	23	0	59	169	0	120.20	37	65.84	CHANGED	shptsppscptus...CsYsVpIcTSCsSPthTpDpISlsFGDAhGNpVYssRL............cDPsu..u.......sF-+CooDoFp.lpGsCht.pIChLYLhRsGsDGWhPEoVpl...Ys....ps.pPV..TFhaNphlPc.sVWYGaNhC	...........h.h.........tstp..CsYslhIpTSCsSst.hTpDpl.Slt.F.GDu..GNplass+L................csPss....t.......sFEcCusDoFp.l..pGsCh....tIC..alYL...h..R..s...G...p...D...GWhP-hVpl.....as.......tsp......p.ss......sF.as.p..lPp.s.sWYGashC............................................	0	4	43	53
+6061	PF06233	Usg		Usg-like family	Finn RD	anon	Pfam-B_11528 (release 9.0)	Family	Family of bacterial proteins, referred to as Usg. Usg is found in the same operon as trpF, trpB, and trpA and is expressed in a coupled transcription-translation system [1].	20.70	20.70	20.90	24.80	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.74	0.72	-4.12	27	204	2009-01-15 18:05:59	2003-06-02 15:31:43	7	1	184	0	72	150	47	81.30	60	86.78	CHANGED	h.LpGYGLTTAEIhY+hPDHPplLQoaVWQ-YDLAPcFPtLhcFL-FWpcElEGsLHSVRhsHp+LIpPuEaRsVsG.hpLH	.........h.QLtGYGLTTAcIhY+MPDHPpLLQoaVWQDYDLAP-FPtLpcFl-FWQcclEGPLHSVpasHp+LIusuEWRsVpGEhhLH.....	0	14	39	48
+6062	PF06234	TmoB		Toluene-4-monooxygenase system protein B (TmoB)	Moxon SJ, Iyer LM, Burroughs AM, Aravind L	anon	Pfam-B_10626 (release 9.0)	Family	This family consists of several Toluene-4-monooxygenase system protein B (TmoB) sequences. Pseudomonas mendocina KR1 metabolises toluene as a carbon source. The initial step of the pathway is hydroxylation of toluene to form p-cresol by a multicomponent toluene-4-monooxygenase (T4MO) system [1]. TmoB adopts a ubiquitin fold [2]. Although TmoB is a component of the T4MO system, its  precise role remains unclear.	25.00	25.00	43.20	43.00	21.50	20.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.77	0.72	-4.12	10	40	2012-10-03 10:59:06	2003-06-02 15:32:22	7	1	34	35	21	39	1	84.00	43	95.51	CHANGED	MALFPlhusFEtDFVlQLVuVDT-cTMDpVAttsAHH...........SVGRRVss...pPGpllRVR+pGssphhPRssplu-uGlpPhEslEllF-c	...MAlFPlhusFptDFVlpLVsVDocsTMDpVAstsAaH...........oVGRRVts...pPGtslRVR+pGst...phhPRshplA-uGlpPh-slElhap.s..	0	10	13	18
+6063	PF06235	NAD4L		NADH dehydrogenase subunit 4L (NAD4L)	Moxon SJ	anon	Pfam-B_10667 (release 9.0)	Family	This family consists of NADH dehydrogenase subunit 4L (NAD4L) proteins from the mitochondria of several parasitic flatworms.	22.20	22.20	22.40	28.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-9.98	0.72	-4.20	12	62	2009-01-15 18:05:59	2003-06-02 15:37:12	6	1	44	0	0	69	0	85.30	41	99.60	CHANGED	MlolhLlhssllllShhLshs+hhNhLIlLENaNVLlLLhCLlhoht-s.+hlFIshMsl.slEl.lhLlVlspshcpuShh.hluh	....MlslhLlh.ssllllShhLshtRhlNhLIlLEsFNVLlLLhsL.Lh.oht-s.+hlFlslMslhTlElslhLlVlsplhcpushh..ssh...	0	0	0	0
+6064	PF06236	MelC1		Tyrosinase co-factor MelC1	Moxon SJ	anon	Pfam-B_10673 (release 9.0)	Family	This family consists of several tyrosinase co-factor MELC1 proteins from a number of Streptomyces species. The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase MelC2 to facilitate the incorporation of copper ion and the secretion of tyrosinase indicating that MelC1 is a chaperone for the apotyrosinase MelC2 [1].	21.40	21.40	25.70	38.40	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.70	0.71	-4.14	9	48	2009-01-15 18:05:59	2003-06-02 15:43:53	6	1	34	23	15	62	1	126.10	37	87.36	CHANGED	lssAAslA.AuushuusspAssAsstuttst..ss.s.........sshssuFDEsY+GRRIpGtssuuGtt..............tauGuatVhlDGh.LHlM+sADGoWlSlVsHYcssPTPhAAARAAVDELp.GA+LhPhPss	..............................................h.hh............h.shhs..h.ssuusstustss.tsssst........sss.sssF.DEsY+GRRIpGsss....s...uustt.............ttuss..a....pVplDGR.LHVMRp....ADG....oWlSsVsHY-sa..sTP......LtAARAAVDELt..GApLtsh...s....	0	3	9	15
+6065	PF06237	DUF1011		Protein of unknown function (DUF1011)	Finn RD	anon	Pfam-B_11463 (release 9.0)	Family	Family of uncharacterised eukaryotic proteins.	25.00	25.00	35.70	29.30	24.00	22.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.29	0.72	-4.13	17	198	2009-01-15 18:05:59	2003-06-02 15:47:15	7	3	89	0	126	188	1	100.00	46	22.74	CHANGED	phsssphsalhhlluhlNuhoNGlLPSVQSYSCLPYGshAYHLussLSslANPlACFlAhFl.hRSlshlusLol.lush..FuuYlhshAuhSPsP.LhssshG	...........................h..tsphsaLhsLlAhsNALTNGVLPSVQSYSCLPYGphAYHLussLuuhANPLACFLAM.hl....sR..SLshLusLol.lGsh..huuYlMshAslSPCP.LhspssG.........................	0	35	46	86
+6066	PF06238	Borrelia_lipo_2	Borrelia_lipopr; 	Borrelia burgdorferi BBR25 lipoprotein	Moxon SJ	anon	Pfam-B_15000 (release 9.0)	Family	This family consists of a number of lipoproteins from the Lyme disease spirochete Borrelia burgdorferi [1].	25.00	25.00	26.80	26.60	22.40	21.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.62	0.71	-4.02	2	99	2009-09-11 01:58:06	2003-06-02 15:48:34	6	2	26	0	6	66	0	103.50	81	97.31	CHANGED	MQNNTIGLGLNLLSSLTNIAKTDTNIDHNYINTFSKVIDFFYKTYISTLKSMETAESTKIFEEIpDILKYNIEIIEAIShDKsK+IITSLKApRNKIMKEYIKhLKRuENA	.....................................MQNNTIGLGLNLLSSLTNIAKTDTNID..HNYINTFSKVIDFFYKTYISTLKSMETAESTKIFEEIQDILKYNIEIIEA....ISTDKSKRIITSLKApRNKIMKEYIKILKRGENA............................	0	4	4	4
+6067	PF06239	ECSIT		Evolutionarily conserved signalling intermediate in Toll pathway	Finn RD	anon	Pfam-B_9306 (release 9.0)	Family	Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1 [1].	24.30	24.30	24.30	35.60	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.64	0.70	-5.49	11	101	2009-01-15 18:05:59	2003-06-02 15:57:31	6	5	84	0	66	104	0	212.70	39	51.63	CHANGED	psptpssusppscps...hhsps.pstpp.hpt...lsshcslFcps..pp+sKssFlchlchFpc+s.V+RRGHVEFIYsAL++MpEaGVE+DLpVYptLL-VFPKthFhPpNlFQphFhHYPRQQpCuIclLEQMEsaGVhPstEschlLlplFG++SaPhpKahRMhYWhPKFKplNPaPlPpclPs....Dsl...-LApluLcRMss.DLpuclTVaQ.hs.spsu.s..c..csaIVuh	....................................p................................tp..p.tps...Ls.hcphFpps..tp+sKssFlpslchFtp+s.l++RGHV-FIYsAL++MtEaGVE+DLtVYptLLDVFP.K.thFh........PpNhhQphFh....HYP+QQpCulslLEQMEsa...G........VhPspEhchlLlplFGc+uaPhpKahRhhYWhP+FKN..lNPaPlP.cslPp....Dsl...-LAphuLc+hss.Dlpuclolap.hs.tsc-shs.....psaIVu........................	0	24	29	49
+6068	PF06240	COXG	CoxG; 	Carbon monoxide dehydrogenase subunit G (CoxG)	Finn RD	anon	Pfam-B_9339 (release 9.0)	Family	The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.47	0.71	-4.51	15	764	2012-10-02 19:24:03	2003-06-02 16:18:11	8	6	531	3	309	754	612	139.90	26	60.58	CHANGED	Gphclsss.ppVachLsDP-plssClPGspSlpttu.sEacsplplplGsl+usa....suclphsplcsssphh.lpscGpGttAGhuhssshhhhspssst.oclsasscsclGGhlAplGu+llcussc+llschhpslusclu	...............................p.plssshppVWssL...sD.sch.ltsClP....G.s.p.p......l....p..t....t.....u...ts...p.....a.p..u....s.....lp.l.cl..G..P...l..pupa................pGpl..pls..c...h...c....ss..p....p..hs...lsuc.G.pu..u..t.u.u.......h..st....u.....s....s.hs..h..h..h........p..s....s........s.....s...T.......plsass...csp....l.u........G.+.l...AplG..s..+.l..l.sssu....c.+lhspFhsshstth.t......................................................................	0	93	183	250
+6069	PF06241	DUF1012		Protein of unknown function (DUF1012)	Finn RD	anon	Pfam-B_9320 (release 9.0)	Family	Family of uncharacterised proteins found in both eukaryotes and bacteria.	32.90	32.90	32.90	33.00	32.20	32.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.31	0.71	-4.73	2	84	2009-09-11 06:58:58	2003-06-02 16:22:51	7	5	32	0	50	86	2	169.20	58	22.88	CHANGED	ARAIIILPTKGDRYEVDTDAFLSVLALpPIQKMESIPTIVEVSSsNhYDLLKSISGLKVEPVENsTSKLFVQCSRQKDLIKIYRHLLNYSKNVFNLCSFPNLsGhKYRQLRLGFQEVVVCGlLRDGKVNFHPNDsEELMETDKLLFIAPL...KKphLYTDMKhENhTVsp..DTRKQVaEcK+SRLpKIIhRPpKSLSKGSDShKGP	.........ARAIIVLAp.ctNADQSDARALRsVLSLsGVKEGL.+GHlVVEhSDlDNEsLVKLVGG-lVET..VVAHDVIGRLMIQCARQPGLAQIWEDILGF-NsEFYlKRWPpLDGhpFcDVLlSFPDAlPCGl...K...p...s.G.KIllNP-DsYV.Lp.....E......GDElLVIAE................................................................................................................DDDo.......................................................	0	6	32	41
+6070	PF06242	DUF1013		Protein of unknown function (DUF1013)	Finn RD	anon	Pfam-B_9390 (release 9.0)	Family	Family of uncharacterised proteins found in Proteobacteria.	20.60	20.60	20.70	106.40	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.65	0.71	-4.19	35	348	2009-01-15 18:05:59	2003-06-02 16:32:47	6	1	348	0	115	277	1365	141.00	57	63.33	CHANGED	LEVpuIADG-VApGIpGhDPlssGQLTp-EI-+scpDPsh+L+lt.sp..shhscpK....KGsRYTPVS+RQDRPDAIhWll+NHPElsDuQIsKLlGTTKsTIpuIR-RoHWNusNIcPpDPVsLGLCoQh-LDttVp+..Aucct	..LEV+uIADGEsApGIKGhDPlssGQLTpEEIp+uEcDPsa+LKLp.sp...stl.s..c.pK.+..KGPRYTPlS+RQDRPsAIhWLl+NHPELpDuQIu+LlGTTKsTIppIRsRTHWNsuNlpPhDPVsLGLCSQlDLDhtVp+Aucpp.....	0	32	69	82
+6071	PF06243	PaaB		Phenylacetic acid degradation B	Finn RD	anon	Pfam-B_9426 (release 9.0)	Family	Phenylacetic acid degradation protein B (PaaB) is thought to be part of  a multicomponent oxygenase involved in  phenylacetyl-CoA hydroxylation [1].	20.70	20.70	21.00	21.90	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.12	0.72	-3.85	43	641	2009-01-15 18:05:59	2003-06-02 16:40:32	6	3	601	2	212	450	72	92.20	56	92.12	CHANGED	ppWPlaEVFlRucpGLsHpHsGSLHAsDschALptARDlYTRRpEGlSIWVVtuspI................................................................................sASsPs-..............+s.hFcPupDKsYRHsoaY.....clP..........................-s......lp+h	.......................WPLaEVFVRuKpGLsH...+...HVGSLHAuDscMALcsARDlYTRRs.EGsS.IWVVtuupI.............................................................................sAS..s..P-E+uthF-PApsKlYRHPTFY......plP...DtltH...................................	0	56	132	180
+6072	PF06244	DUF1014		Protein of unknown function (DUF1014)	Moxon SJ, Coggill PC	anon	Pfam-B_11009 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	21.30	21.30	22.60	22.50	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.66	0.71	-3.90	14	313	2012-10-02 14:16:02	2003-06-02 16:51:30	7	4	282	0	212	300	4	148.50	32	66.20	CHANGED	T+AQItcphpc-pptpct.pptppt.......-h.hEc..shNhph.-pspsE.............................................ARol--AIusLSlsc.....shD+HPE+RhKAAapAaEEspLPcLKpEpPshRLSQhKQlLhKEWpKSP-NPhNQ+	........................................................................................................................t............t...t..t...t.pttp..t.ttth.....t..hp...c....ht...s.....p....t.....t....tt..-...............................................................................................Aps.lDsAls....sL.olssp.............thDRHPERRh.KAAYpAFEEpcLPclKp..E..p..P..uLRh.....sQhKphlhKcapKSP-NPhNQ........	0	75	120	176
+6073	PF06245	DUF1015		Protein of unknown function (DUF1015)	Finn RD	anon	Pfam-B_9451 (release 9.0)	Family	Family of proteins with unknown function found in archaea and bacteria.	19.70	19.70	19.80	20.20	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.30	0.70	-5.97	97	830	2009-01-15 18:05:59	2003-06-02 16:53:50	6	6	778	0	268	769	822	388.30	33	97.45	CHANGED	plpPF+ulRsstchstpluu.....PYD.VlsspEtcphhptsPaohl+lphPchshs.ths..pp..YppAtcphpcahppGlLhpDppPshYlYcpphs.s.........ps...ppGllussslc-Yp.....pshI++HEtThts+cpDRlphlcsssANsuPlFlhYpc..spplspllpphh.p....ppPhh-assp.sGlpHplWhlsDtphlpplpphF.tthp................slYIA..DGHHRhsoAhphtpcpcppss.ths.upE.saNahhshL..hscspLpIhshpRlV+sL.suhs.cpalpplpph.Fplpphs.....................................................t.htssppppauhY.lss.paYtLph+p....t...t.p..ss.........lppLDVslLpchlLpslLGI..ps.Rs-p+IsaltGhcslh.....h.ctVcsGp.hplAFhlhPsslcplhsluDsGplMPsKSTaFtPKLtSG..Lhl+pl	...................................................................l+PF+ulR.Pst..p..h.st.......plA.u.....PYD.VlsscEs.cphhp.ssshShl+l.psEhshs..shs.hsp..............Yp+AscshppahpcGhlhpDpcsshYlYc.phs.u................+sQpGlVssssl--Yt.............ssh..I++HEhTht-+EtDRhchlcsssAphsPlFlsYcs.....ppt....l...p.pllppht.p..........ppPhY-Fss.....DGhpH.phWhls-p..phlpplsptF.t.p.h.s...................slYIA...DGHHRsAoAsp....lttc+cpp......t............s....t....ht..sp...............c....taN.............aFLull..hscspLpIhsYNRVV+..cL.....pshs.cpF.L.pp.lppt..F..p.lcphs.........................................................p.hp..P.s..p..hpsauhY.lss..p.aY..pLss+t...t..th.sp.........cs............................................lpsLDVsl.Lpsh..lLs.lLuI.....pD.Rs..-..pRI-FluGl+ultt............ctVssup.hplAFslaPsshcplh.slADsGplMPPKSTaFEPKLcSGLhl+ph..............................................	1	143	226	256
+6074	PF06246	Isy1		Isy1-like splicing family	Finn RD	anon	Pfam-B_9462 (release 9.0)	Family	Isy1 protein is important in the optimisation of splicing [1].	20.20	20.20	20.30	21.10	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.73	0.70	-4.98	31	342	2009-01-15 18:05:59	2003-06-02 17:00:10	7	8	291	1	245	340	3	234.50	38	85.85	CHANGED	MARNsEKApSMLsRapptppsphthhct....+RPphsscsssLspAE+WRppll+EIo+KVscIQssuLu-apIRDLNDEINKLh+EKppWE.+Ip.pLGGPsYp+hus.p..hhDscGp..clsG....scGY+YFGtAK-LPGV+ELFE.ppppt.........tps++sRtc........hh+plcssYY.Ga.tDE......-DshLlthEtphEcphhpp.h.p......................t..thtttp.pphht.h.t..t.................................................................th.lPopp-lpp.llc+++pcLLp......Kh	............................................MARNsEKA.ohLsR.apptptt-tth.................hc.........RRPhhsocspslspsE+WRt.pll+.EIo+KVspIQs.............suL......u.-apIRDLNDEINKLhREKtpWEhpIc.pLGGPsY....t+.hus+...hhD...p.-G+...ElPG..............s+GY+YFGtAK-LPGV+ELFEpps............................ccs+tc...............h.h+pl.Ds.pYY.GY..hD-.......-DuhLl.h.Et.phEcphhtph..h................................................................................tttp...........p...h.....t..tt.......................................................................................................hhth.lPo.p-lpp.llc+++.cLlpc.........................................................................................................................................	2	89	138	204
+6075	PF06247	Plasmod_Pvs28		Plasmodium ookinete surface protein Pvs28	Moxon SJ	anon	Pfam-B_11346 (release 9.0)	Family	This family consists of several ookinete surface protein (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals [1].	26.00	26.00	26.20	27.30	25.00	25.90	hmmbuild  --amino -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.65	0.71	-12.07	0.71	-4.73	11	164	2009-01-15 18:05:59	2003-06-02 17:02:55	6	2	22	5	12	166	0	197.10	58	88.67	CHANGED	KVTVDTlCKNGhLIQMSNHaECKCspGaVLhsENTCEcpV.cCcc.-slsKsCG-YuhChspus.sp.psh+CsChsGYhlspslChPscCpshsCG.sGKCIlDssNssps.sCSCsIGKl....pNsKCTtsGcTcCsLKC.KtsEcCKhsstaYcClscsuustsusutsp................................................sss.......SlhsGhSlhsILsLhllal...hl	...KVTs-T.CKNGalVQMSNHFECKCN-GaVhh.sENTCEEKp.-Csp.pslNKsCG-YuhCssst.ssppcsh+CGCI.GYTlhp-..lCsPs+Cps...l.CG.pGKCILDssNsNso.hCSCsIGps...--sKKCsKsGcTcCoLKC.KsNEcCKpspsaYKClsKsuustsuuutss..................................................s.us........SlhNG.uVhsIL.h...hah..s.............................................	0	3	5	10
+6076	PF06248	Zw10		Centromere/kinetochore Zw10	Finn RD	anon	Pfam-B_9476 (release 9.0)	Family	Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis [1,2]. These proteins bind to the centromere/kinetochore [2].	19.30	19.30	19.60	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	593	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.86	0.70	-6.36	12	279	2012-10-03 17:31:52	2003-06-02 17:10:26	8	11	205	0	185	344	1	435.20	19	61.30	CHANGED	h......................tpsstlph-.Dhptpls+lpp+lcchpscVpshIsccYs..-FhsshpusppllppsctLsc-l.DlLps.lps-lhtsLpsuss-hsphpppLccsthslpllppL..chcsth.....cphspALpsKsYltsAchLpch+shLctlps.cspp.............LchhpuLphEhplptppLl.pLsccap+Ll.aphsop.......pshhpspLpLsptpsp.........LssVl.Ahsh.GpLppplcthsphLlc.llcPLIspPshhsss-pppc.s.....lhLsappp.......pophc+sssppVap+lhhllcsLpphhhslssppp..........lhpllGchlhcclschlIccCLshuIP..ssuschpp.appllppsp-FEptLK-htals.s-s.osL.cYAcslssaFssK+CpcVlssARpLMpp-hashVh..........lsPp........................................................................t..t.cstppluptohshPsChlScSsp.cLMcLhhpsLpEs.ssusttsuspLhholcslhpLahssVPphHcc.LtplPQhuAlaHNNCMYluHaLhshuaphph.....h...hsoFsDlVsshRphGscsFhsQhphQ+upLh-tLsutp.Fpph.ssccphos	.................................................................................h..t.....phptpl................p.ht....p.....ph........ph...........hpp...s.......pth...htp....spthtpcl...........th..h.pt....h....t...p................................h.tt..plpss...scht.lpp..plp..p.p.hhph...lp.p....l.....tphpphl............p.ph..ptshtp...t.phhtuh..p......hlpphp.thl..p......................p......................thhp.lp.c.....ht..pppl..tLtp.apphl.h.p.......................phphtt.t.t.tt...............lp.phl.uht.h.t.l..t....th..tp...htp.lhp.hlpP.hl........s...h..............t....................l...ph..............................tt.t..s.ttlhtpl...h.lhph.lpp.l.................................................h.p.huphhh.......p..h.phllpphL..ulP...ps.pphtp.ap.pl.lp.pstp.Fppt.Ltp..........hthh............t.................p...........tL.paspph..hahp+hp.phl.ts.Rplh..t......t.............................................................................................................................................................................................................................................................................................................................................t...................................................................h...............hh.ha...............t.....sh....h..Nsh.ah...h...............................................................................................h......hp.....t...h..............h........................................................................................................................................................................................	0	64	100	147
+6077	PF06249	EutQ		Ethanolamine utilisation protein EutQ	Moxon SJ	anon	Pfam-B_11530 (release 9.0)	Family	The eut operon of Salmonella typhimurium encodes proteins involved in the cobalamin-dependent degradation of ethanolamine. The role of EutQ in this process is unclear [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.69	0.71	-4.67	4	785	2012-10-10 13:59:34	2003-06-02 17:11:56	7	4	744	3	116	676	368	139.80	48	71.45	CHANGED	hoKELlEpLl+pVlcEKhu.tpst.p.s.h+phD.SGIhulKL.sspsscpsRhDTGNP+DVVhTpDLhTL-ESsRLGAGlMEMK-TTFsWTLsYDElDYVIEG+L-llIDGRplsAcAG-lIhIPKGSpIcFSVss.A+FlYVsYPAsWpS	................................................................................................hscpLltpLhcK.VhpEK.uhp.........t..p...s.h.pphs...GhuulKll-usol+hs.RFDs.up.Pc...sVuhT.DL..VT..t.-..-...u...s.s..MuAG.FM.ph.....-...s..u...h..F..P..W..T..L..s..Y......D...E..IDh..VL..E..G..-..L...cV..c..c.-...G.....c..T...h.l..A+..AGDVhFIPKGS..o..I..cF..u..T..s..u..s..s.+..FlY.VsaPANWQS........................	0	41	76	99
+6078	PF06250	DUF1016		Protein of unknown function (DUF1016)	Finn RD	anon	Pfam-B_9571 (release 9.0)	Family	Family of uncharacterised proteins found in viruses, archaea and bacteria.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.79	0.70	-5.46	7	1895	2012-10-11 20:44:44	2003-06-02 17:15:21	6	10	943	0	343	1531	191	214.50	28	90.17	CHANGED	lht-I+phI-puRpcshpuVNupLshhYWpIG+hIlEtpptGp.+AtYGtpllppLu+cLsp-as..+GFospNL+pMRpFhhhasc..hhtsLhtpLoW.....oahplL.plcst.pRsFYhcpshcptWSsRpLptQIsohhYERphlS+c.pcshpp....h.stpphpsc.sl+DPYlL-FLuLt-p..a.E+-LEpullp+LppFLLELGsGFuFVuRQ+RlplDsccFaIDLLFYphtL+Chlhl-LKlGcFphp.hGQMphYLpah-ch.+pPs-sPsIGlILCssKscs.lcYsLptpppslhsuEYKh.LsscEpLtpcL.pt	...............................................................................h...h.ttp.thh.thN..hh.hha..lGp.l.t........pttaGtthlttlu..tlt.th....pG..hs.psl..hh.ah..a.......................................................h.......h......p............t....h.....................t...........p...................l..........s...........h....................p.h......h...t....h.t.p.....tt...a.Y...s.htttWo.t..L...htt..hat+.....s...........................................................s....hh+s.h.h-hht...h.....t........h...Etphcttlhtph.pahhEhGtsF.a.spp..h..h.t.t......p.hhhDh........lhaph.hpthlh.h-lK.t.ht.t.huphthYhthhpt........t.-.t.slGlllCtttt....hph.h.......t.hhhupa.........h.............t.h.......t..........................................................................	0	95	224	306
+6079	PF06251	Caps_synth_GfcC	DUF1017;	Capsule biosynthesis GfcC	Finn RD, Sammut SJ, Bateman A, Eberhardt R	anon	Pfam-B_9574 (release 9.0)	Family	Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation [1].  This family plays a role in group 4 capsule biosynthesis [2].  These proteins have a beta-grasp fold [3]. Two beta-grasp domains, D2 and D3, are arranged in tandem. There is a C-terminal amphipathic helix which packs against D3. A helical hairpin insert in D2 binds to D3 and constrains its position, a conserved arginine residue at the end of this hairpin is essential for structural integrity [4].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.48	0.70	-5.19	17	1054	2012-10-03 10:59:06	2003-06-02 17:25:22	6	19	714	4	140	613	338	216.40	40	55.92	CHANGED	tsshsVplhtssp...phplsassshRLtplVtps.............pshshaW.uAsLh-..tpupscpppQplLtpLuphup.....pssschtushppLtpQLptlplstRlhhsLD.DhlRlscptNP.L.pGpYhLhlsP+sspVolhGhV..p.......psGshsapsttsspsYLpptsLlssA-pS.salIpPDGpspptPlAYWNcpah-hsPGuhlaVsF..t.osh.pphs..sLNppIlpLLpNRhsh	..........................................................................................................................h.stssVpla..Gp...ppsholsssEplhpLVsQP...................hhsp...WWP.uA.l.ls..-p......A......p......u..t.......Ah..p.......pp.....Q....tlh.s.p...LA.p..htA...................-uss..D..s..A..A......s.I.......ps......l.....Rp.....Q.....lps..Lc....l......T......G...R.......h..l..p.L.D.P....D..hVR..V...s..E....p....u....N.P.PL...p.............GsYTLals..spP.s.TV...TLhGhl..S.........psGp.P.ap.sGR.sVssYL....p....s....p.s...h.L.u.G.AD.+s.........h.s.aVlhP-Gc.o..p..p........A..P..V...A..h....W...N..K...R..H..l..E.....P...PGShlalGh..usplh....stp.s..sLNspIlpsLTQRlP.t............................................	0	33	78	110
+6080	PF06252	DUF1018		Protein of unknown function (DUF1018)	Moxon SJ	anon	Pfam-B_11125 (release 9.0)	Family	This family consists of several bacterial and phage proteins of unknown function.	27.00	27.00	28.90	27.70	26.40	26.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.61	0.71	-3.59	54	451	2009-01-15 18:05:59	2003-06-02 17:38:09	7	3	363	0	82	413	9	116.80	26	75.27	CHANGED	hDD-sYRshLtp.....hsG+pSspchs.spLppVlcthcp.pG..F............hppstt...................p.ts...t..hs.......pss.hcKIcAlWhphtptsshtp.sct.ALssal+Rhh...........tlsslpaL..p.sppsppllpuLKp...Wpp.Rt	......................................hDD-sYRshLtp.....h.s.GKs..Ss+chshspLp...pVlpthcp..pG..F...................p....pttt...................p.ss.............t.shs...........pts.hp...KIpAlWtphstth...........s..p.....uLs....tal++hh..............sls.p.....lpaL..s..sppsppllpsLKp...hppR................................................................	0	30	58	73
+6081	PF06253	MTTB		Trimethylamine methyltransferase (MTTB)	Moxon SJ	anon	Pfam-B_11132 (release 9.0)	Family	This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.	25.00	25.00	25.80	25.70	19.40	17.60	hmmbuild  -o /dev/null HMM SEED	505	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.52	0.70	-6.74	8	451	2009-09-10 22:07:33	2003-06-02 17:43:21	6	2	119	2	177	465	1554	462.60	30	97.03	CHANGED	tRpuGRtuR+A.Russuspphsh.plspshsshplLs--plEtIHcsuh+lLEElGI-shs-.pAl-lacpAGAcVt.cstRVRh-+ulltEhlposPusFTlHARNPp+slplGGpslsFussuGuPpVpDl-+GR.R.GsLtDapNhs+LApthsslHhhGsslCEPhDlsss.pRHL-slauplphSDKsFhsospu+tRApDulEMhtIstGt..-phcssP.sshoIINsNSPhhaDtsMsculhshActGQsllloPFsLuGAMuPVTlAGALsQpsAEALAGlALsQLlRPGAPVlYGsFsSsVDM+SGAPuFGTPEsupushsuGQLARRYsLPaRTuuu.suSphsDAQAAYEoshuhauAlLuGuNllhHuAGWLEGGLssSYEKhllDh-hLtthhcalpulslsE-sLuhDAItEV...GPGGHFhGspHThc+YpTAFYpPhluDapsFEpWsEpGupDttpRAsclWKchLA-YEtPhlDsAlcEsLc....-alA+R+schG	...........................h...............................................hphLsc-plptI...apsuhclLE-lGlphhss...pAlclh+puG.A.p...V............ps......p..pV...+hscsllcchl.t.pAPp..pFTh.puRss...c..c.slplG..G..p..p.hhau..ss.hus.........P.hl.hD.h.c.s....s+...R........uoh....pDhtshs+Ls.phhsslchs.u.s.ss.stP..pD..ls.....ss..ppcl.s..h..hhs..p..l.phocKs........hh.....ss......s......s..s.....pps......pc.....s.......l..-M........sp.....lhhGt.......-...hc..pps.....hh...h.s.h.hs.ss..SPLpaspshhpslhthuctsQssllss.hshuGAhuPsolAGslsQs.AEsLAGlshsQllpPGsPsla.Gsasosh.DM.+..o.G.usshGoPE.shhshusuQl.A.+.h.a.sLP.h+suuu.hssuKhsDsQAuaEsshohhhuhhu.GsNhlhHuuGhL-uhlssShEKhlhDs-hlshhp..+hh.cG..l..ph..s.........-..c..s..l..uhD.sI.c.c.V.......G..P.s.GHaLuptHT...ppaps.s.a.ahP.tlh.Dpp..shcp...Wp.tt.G.t.hshhp+AptthcchLss....a...p......P...l....DsslcctLp....thl.......................................................................	0	84	140	150
+6082	PF06254	DUF1019		Protein of unknown function (DUF1019)	Finn RD	anon	Pfam-B_9681 (release 9.0)	Family	Family of uncharacterised proteins found in Proteobacteria.	19.60	19.60	21.50	20.70	19.20	18.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.17	0.72	-3.82	12	911	2009-01-15 18:05:59	2003-06-02 17:45:42	6	1	343	4	26	400	0	86.30	43	56.64	CHANGED	phs-........slspNRQKlF.RWLcs..DopttR-plptLhPAIhusL...PhEh+sRlps.sshh.hlspht.KEhs-Appulhh......hh+-ls-tIssh	.............................hPc..ALupNpQKIF.RWlcp..DT.DthEKhpALlPAI.cAh..............P.h..Lhs+...hpstpShha........+Els-s+-pl...........l+-sD-hlts................................................................................	0	2	7	12
+6083	PF06255	DUF1020		Protein of unknown function (DUF1020)	Moxon SJ	anon	Pfam-B_11136 (release 9.0)	Family	This family consists of several MafB proteins from Neisseria meningitidis and Neisseria gonorrhoeae. The function of this family is unknown.	25.00	25.00	46.30	41.60	24.20	24.10	hmmbuild  --amino -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.92	0.70	-5.23	15	288	2009-01-15 18:05:59	2003-06-02 17:46:46	8	13	49	0	16	255	0	227.60	44	62.34	CHANGED	DuFIRDshQRQHYEPGGKYHLFGssRGSVu-RoGpIslhpspoHplGNLLI...QQAuIcGsIGYpsRFSGHGHEVHSPFDNHAS+SsSDEuGuVD-GFTVYRLHW-GaEHHPADGYDGPQGGsYPtPsGARDIYSYalKGTApsIKLNhTDsRShuQRlhDcasNAGSsFosRADEAsK+haEasPcLDRhGNuMEslNGlAsGAlNPFluAGEulGlGDIlpGsspulshAA.......M+sLGsLSsEuKhAsIssLuDsAthcKsutsAl+cWAspNPNAApTlEAllNVh.AAhslhth.................K+spLsssAhPhGKuAVSssFutu....YpsP.tuRs	............DshlppshptpHaEPsGKYHLFGs.RGpltpRshtlthhp..s..huslh....ppsshpG.lGY.s+FSsHGaE.HuPFDpHsucSsSc.tGssstG..FolYplphpG.EhHPtDuYDGPpGusYP.PtGARD.YoY.lpGsupph+hN...........ssptshtpRh.cp.tshuu.h.ptss-u.+hhhc.ssphsh.uNtM-.lpGls.tGAhNPhlsuhphlGhGshh.uh..s.s.ss.......hpslu.LssEsphAhhs.Lts.A.h.cpshpuscpWhptpPNhstTspsshslh.AA........................KhspLs.sths......sKsss....................h............................................	0	5	5	5
+6084	PF06256	Nucleo_LEF-12		Nucleopolyhedrovirus LEF-12 protein	Moxon SJ	anon	Pfam-B_11198 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus late expression factor-12 (LEF-12) proteins. The function of this family is unknown [1,2].	25.00	25.00	141.00	121.10	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.15	0.71	-4.51	12	26	2009-09-11 05:10:50	2003-06-02 17:51:17	6	1	25	0	0	23	0	176.70	38	87.59	CHANGED	spcpFppRLsYVssIsshMpcTLchMshpGthocsDAsTLClADDTAAWlCGRscsss.FsSFRl+hut..F.ppsspsLp+FhFEESLtQ+h.....tshs+YTYMNYsl.hcs.lAIKLsVhht..chcsD........sLsYFVshtsupspshs.........................csssshphpLs.......hEchlEEhlspussp	........pppFspRLpaVssIsshh+csl-hMsppsthopsDAsoLClADDTAAWlCGRlssss.FVSFRl+hst..F..c+sspsLc+FtFEESLtQph.....pshs+YsYMNYol..pshlAlKLlVahc..shpss........sLsYFlpststpspppsp.h.+....................cpss.hphsLsh......hEphlE-shsptlV........................	0	0	0	0
+6085	PF06257	DUF1021		Protein of unknown function (DUF1021)	Moxon SJ	anon	Pfam-B_11556 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	26.30	30.20	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.51	0.72	-4.29	44	1201	2009-01-15 18:05:59	2003-06-03 09:26:38	6	1	1190	2	152	402	3	76.60	46	88.55	CHANGED	hspsLssIKpsl-s+lGc+lpl+AssGRKKhhc+pGlLccTYPulFVVc..LDpp......psshcRVSYSYoDlLTcsVplpa	...............sppltcIKppl-sHlGpplhlpApsGRK+p..hpRpGlLtETYPSlFlV-..L-ps......psshp+VSYoYoDlLTEslplpa....	0	56	98	125
+6086	PF06258	Mito_fiss_Elm1	DUF1022;	Mitochondrial fission ELM1	Moxon SJ, Eberhardt R	anon	Pfam-B_10595 (release 9.0)	Family	In plants, this family is involved in mitochondrial fission. It binds to dynamin-related proteins and plays a role in their relocation from the cytosol to mitochondrial fission sites [1]. Its function in bacteria is unknown.	21.80	21.80	21.90	23.40	21.20	20.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.77	0.70	-5.48	31	342	2012-10-03 16:42:30	2003-06-03 09:28:41	6	2	271	0	131	321	1802	296.30	25	87.47	CHANGED	sGpcsQshGLucALuh................................shphpplthpp...................................h.th..h.ssshs...shPcLlIuuG+pTthhshhl++htsst.hsVtlhcP+hs.hppFDLllsPpHD......................pl.sssNV.....lhohGulptlssttltpstt.....ht...+splslLlGG.soppaphssp.htplssplpslhppts.h.plhlTsSRRTPssstshLpphht.....hstl.la..stss....sNPahshLuhADslhVTsDSsSMlsEAsuoG.sPVhlhsls..s.pps.+hschhspLhppGhl+sasuh..hpt..ht.htPLs-s.....s+sApplhpchth	......................................................................................................sGppsQshuLsptLsh..................................................................................................hp..h..hplphpt............................................................thh........s.hh......sht...t....h...th.htt..hpt.....PslllusGpps.t.hshhl+....+....hh..ts.hhslplh.....c......P.phs....hstFDhllsPpHD.............................................th.tssNVlhhhGulptlssttlttst.th.....t...h.....h.................psh.l.slllGG.ssp..p.apaspp.htplhptl.pplhpsps..hslhlosSRRTPtps.tshlpptht........t..s..pl.la......stss.....N.P.ah.u.hLuhA-tlllTsDSlSMloEAsuoG.pPVhlh..shs.....t...pps...+hpp.hhppLhpp.thhp..h.s.t...h.t.........h.s..lp-stchAt.lht....t....................................................................	0	45	94	109
+6087	PF06259	Abhydrolase_8	DUF1023;	Alpha/beta hydrolase	Finn RD, Bateman A	anon	Pfam-B_9720 (release 9.0)	Family	Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.30	0.71	-4.78	6	556	2012-10-03 11:45:05	2003-06-03 09:31:10	7	6	239	0	146	545	20	174.30	31	36.72	CHANGED	DPtspshAApssGDl-sA-+VSVsVPGlsoss...ppohsshhttstthttcshstpptAu.ss..ssAsIAWhGYpsP........ussuhsssTsspAcsGAscLsthlcsLpAso..sstcloLFsHSYGSlVsuLAhcs.....ss.VsDlVlhGSPGhcAsssApLGs-.u+sasMpus-DaIppl.Pplus	.....................................................................................tpshAslulG.ss.D.s.A.cc.VuVh.VPGssosl...................pssh..s..s...h.p.p.s.ts...h..t..........t....p............h.....hp..tp.t..s.u....ss...........ssAsIAWhGYcs.P.......................ss.s.h.hp..s.s.ss.s.h.A.....csG.AspL....sp.Fhpu...L................p.....u............s.......p.....ss.......s...s..c.............lTllGHSYG.S.l.lsu.h.A.hpp.................s.h.t.ss-.l.V.h..h..G...S.P..G..h..............s....................s...s........s..........s......u.......p......L.sh..s...............u.+s..as.hp.u..s..s.D.lt.......s..............................................	0	60	119	141
+6088	PF06260	DUF1024		Protein of unknown function (DUF1024)	Moxon SJ	anon	Pfam-B_11584 (release 9.0)	Family	This family consists of several hypothetical Staphylococcus aureus and Staphylococcus aureus phage phi proteins. The function of this family is unknown.	21.20	21.20	22.30	22.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.91	0.72	-3.83	3	370	2009-09-11 11:00:23	2003-06-03 09:32:37	7	1	210	0	4	184	9	79.50	82	96.81	CHANGED	MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGlsNAhQ-ulKEsItLDEAlGIMsuQVlYEYEEEQENE	.......MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGlsNAhQculKEsItLDEAVGIMsGQVVYKYEEEQEN-................................	0	3	3	4
+6089	PF06261	LktC		Actinobacillus actinomycetemcomitans leukotoxin activator LktC	Moxon SJ	anon	Pfam-B_11552 (release 9.0)	Family	This family consists of several Actinobacillus actinomycetemcomitans leukotoxin activator (LktC) proteins. Actinobacillus actinomycetemcomitans is a Gram-negative bacterium that has been implicated in the etiology of several forms of periodontitis, especially localised juvenile periodontitis. LktC along with LktB and LktD are thought to be required for activation and localisation of the leukotoxin [1].  	25.00	25.00	27.10	140.60	22.50	20.80	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.99	0.71	-4.50	2	18	2009-01-15 18:05:59	2003-06-03 09:42:17	6	1	11	0	0	10	0	139.60	91	99.45	CHANGED	MSuTEYAPFYLRFIQFPsNEV.LhEYWpLVQN.VpKlp+ITVhhAQIlGhhuEKsIWKYQuTFNDGhLEsEVAK.-VSLTLRNSALLVASAIVIHFKSNFTNLLILSQITQYppahPh.KKSKY.PLYhSCLLRRRLTEFKITLLPLPWG	MSGTEYAPFYLRFIQFPSNEVLLYEYWKLVQNFVQKVSKITVRLAQIVGILGEKTIWKYQSTFNDGMLEGEsAKQEVSLTLRNSALLVASAIVIHFKSNFTNLLILSQITQYCRHRPKPKKSKYFPLYLSCLLRRRLTEFKITLLPLPWG......	0	0	0	0
+6090	PF06262	DUF1025		Possibl zinc metallo-peptidase	Finn RD	anon	Pfam-B_9726 (release 9.0)	Family	This is possibly a family of bacterial zinc metallo-peptidases. Although they carry the HExxHxxGxxD motif, they are missing a final methionine which would class them as Met-zincins.	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.09	0.72	-4.20	78	911	2009-10-19 15:30:34	2003-06-03 09:47:56	6	14	671	2	290	712	69	87.30	28	61.27	CHANGED	hssVslhV-Dh..Pstt.hsphtht...pLLGLYcGlsLo-+ush...uthP..DpIhLaRcPlLchh......s-cs-..Ls-.VpcsllHEIuHHFGlSD--lct..lsh	..................................................tl.h.ltt...s.....................................lhG.ap.Ghslsp...ps........ssthP..s+IslYRcPl.phs.........ssc--..Ls-..hVpcsllHEluHaaG...ls--clctht.........	0	93	203	253
+6093	PF06265	DUF1027		Protein of unknown function (DUF1027)	Moxon SJ	anon	Pfam-B_11526 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	81.90	81.60	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.93	0.72	-4.11	32	1012	2009-01-15 18:05:59	2003-06-03 10:12:50	6	1	1008	1	97	433	0	85.50	54	52.69	CHANGED	lplsshpacllcNh+-uF-tEthtpRaS-lLsKYDYIVGDWGh-QLRL+GFYcDsspps.hDp+IosLpDYLhEYCNFGCAYFVLc	.....lplsshtacLlcNa+-uFc.EpFtpRaS-l.LsKYDYIVGDWGh-QLRL+GFYcDsspcs...hsp+ISsLpDYLhEYCNFGCAYFVLc.........	0	20	49	73
+6094	PF06266	HrpF		HrpF protein	Moxon SJ	anon	Pfam-B_11646 (release 9.0)	Family	The species Pseudomonas syringae encompasses plant pathogens with differing host specificities and corresponding pathovar designations. P. syringae requires the Hrp (type III protein secretion) system, encoded by a 25-kb cluster of hrp and hrc genes, in order to elicit the hypersensitive response (HR) in nonhosts or to be pathogenic in hosts. The exact function of HrpF is unknown but the protein is needed for pathogenicity [1].	21.70	21.70	22.60	23.50	21.30	20.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.39	0.72	-3.85	7	64	2009-01-15 18:05:59	2003-06-03 10:41:15	7	1	59	0	13	36	0	73.40	46	98.66	CHANGED	M.ShsuLQRRLDsshpcApsplD-AshpuuEu.ho.sD.aAFhEAuhphusAShAssQpLpsKHGLsKAlIstIp	.....MhShpuLQppLDoshsRAposlDDhsLsuupG.hot-DhpAFsEASpphusAS.AAsQphpstHtlsKslI-uhp..	0	0	3	8
+6095	PF06267	DUF1028		Family of unknown function (DUF1028)	Finn RD, Bateman A	anon	Pfam-B_9747 (release 9.0)	Family	Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolism.	25.20	25.20	40.70	32.70	22.70	22.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.13	0.71	-4.87	78	406	2009-01-15 18:05:59	2003-06-03 10:49:56	7	10	357	2	175	408	353	190.90	39	75.84	CHANGED	TFSIlA+sspTGphGlAluSs.lAV....Guh.lsas+AGVGAVATQu.hssPth.GspuLchLppG.hsAppslpplhssD..sttchRQlsllDspG....psAsaTGspshsh...tuphsGps..hustGNhLssspVlpAMspuFpsss..................st...Lu-RLlsALcAGpsAGGDtR....u..hpSAALhVss....ptsa..........shlDLRVDhpsc..P...ls-L	...................TFSIlA+..ss.......c...oG.......p..hGlAluSp.hAV.....GAh.sPascAGVGAVATQs.h...ssPsh..Gs...puL..chLc.p......G.....hssppuLctllssD.............sttphRQlsllDspG...............psAsaTGpcs...hs..h.............tuth..sG..c....s.................hsstGNhLuutpVlpAMspuFpsss.....................ut....Lu-RLlsALpA...G.sAG.G-tp......s...hpSAA..LhVls...ptsa...........sh.lDLRVD.pps...PlscL.................	0	57	107	144
+6096	PF06268	Fascin		Fascin domain	Moxon SJ, Bateman A, Finn RD	anon	Pfam-B_11660 (release 9.0)	Domain	This family consists of several eukaryotic fascin or singed proteins.  The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture [1].\	      Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerisation and binding to microfilaments only at pH values below seven [1].  Members of this family are histidine rich, typically contain the repeated motif of HHXH [3].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.38	0.72	-3.97	23	817	2012-10-02 19:42:32	2003-06-03 12:37:00	8	24	166	30	411	843	24	107.60	21	63.95	CHANGED	ssta.ssc+hsscLsAstts.psh...........plapLphpss...shs..L+.opsG+YLshtscGpltspsp....tssstFplchp....u+hshhptspG+YLs..ussupLpu.pusssupsELasl	............................................................................................thh.sspp..t.h.p.lsustt..p.tph...........ph.apLp..hssp..................shth...l.....+..o.p..sG+..Ylsh.ts.cG.s..ltssss.........ssssh...F.p.lphp...........sph...s..h..h..ptssG+YLs...hss.sG...pLt.u.pupssu..tsEhath.........................	0	103	156	257
+6097	PF06269	DUF1029		Protein of unknown function (DUF1029)	Moxon SJ	anon	Pfam-B_11672 (release 9.0)	Family	This family consists of several short Chordopoxvirus proteins of unknown function.	25.00	25.00	63.20	62.70	17.20	16.10	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.75	0.72	-3.96	11	43	2009-01-15 18:05:59	2003-06-03 12:41:20	7	1	37	0	0	21	0	53.00	63	99.48	CHANGED	MITNYEPlILlsIlshullsNhplSpKsKlDIIFhlpollFhWFlFHFlHSVh	MISNYEPLlLLsIhCssLLhNFslSSKTKIDIIFslQoIVFhWFIFHFVHSsI..........	0	0	0	0
+6098	PF06270	DUF1030		Protein of unknown function (DUF1030)	Moxon SJ	anon	Pfam-B_11673 (release 9.0)	Family	This family consists of several short Circovirus proteins of unknown function.	25.00	25.00	128.20	127.60	16.20	14.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.85	0.72	-4.43	2	10	2009-09-11 20:47:49	2003-06-03 12:43:03	6	1	6	0	0	7	0	53.00	95	88.33	CHANGED	MVFIIHLGFKWGVFKIKFSELYIHGYTDIVVLVVaTVFERSAEAYhVaISpuL	MVFIIHLGFKWGVFKIKFSELYIHGYTDIVVLVVFTVFERSAEAYVVHISRGL	0	0	0	0
+6099	PF06271	RDD		RDD family	Bateman A	anon	Pfam-B_1111 (release 9.0)	Family	This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family.  This region contains two predicted transmembrane regions. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.86	0.71	-4.28	114	4557	2009-09-14 12:06:15	2003-06-03 12:48:13	7	44	2499	0	1260	3598	868	135.70	17	61.94	CHANGED	hushhpR.hhAhll.Dhllhhhlhhlhshhhhh.............................................hhhhhhhhhhhhl.........hhhhahhhhhth..tGpT.lGKhlhsl+lls..............psupth....sht..pshlRthh....................................................h.hhhhhhhhlshlhhhh......spc+..p..slHDhlu.s	.............................................................sshhpR.hhAhll.Dhhl..lh.h.l.h.h.h.h...hhhhhh..................................................................................................................h.h.h.h.h.h..h..h.h.h...h.hl............h.h.h.hah..h..h..hhth......tGpTlG+thhtl+lls............................tsu.p.p.l.......shh.......p.sl...l.Rthh.........................................................h.hh..h.h..h..h.h..h..l..sh..lhshh...........s.tc+.....p.shtDhhu....................................................................	0	414	844	1088
+6101	PF06273	eIF-4B	Plant_eIF4B; 	Plant specific eukaryotic initiation factor 4B	Moxon SJ	anon	Pfam-B_11679 (release 9.0)	Family	This family consists of several plant specific eukaryotic initiation factor 4B proteins.	28.00	28.00	28.40	28.20	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-13.00	0.70	-5.74	6	148	2009-01-15 18:05:59	2003-06-03 12:55:18	6	5	33	0	89	145	2	231.40	23	78.73	CHANGED	MS...KPWGGl...GAWAh-AERAE-EptppA......sA.......tAsAsotsFPSL+EAAsupu....p+KhKphoLSEFphssYsts.........potGLTpp-hh.LPTGPRQRSt-Ehp.uRLGGGFpSY...t.........................GGGRpsYuGGFDsDpRs.tsRsSDhspsS..................................RAD-lDDWu+sKK..PhPSh-ptcpu.RYsu.......................hGGGGGG............uht.......Ghts.stusDsDpWuRuc..ss.........hscsG..................cERPRLlLpP.Kt-ssuo.s.Pss..tpS+PuPFGAARPRE-lLAEKGLDW+Kh-o-IEtK.....TSRPoSupSSRPuSApSspstSsh.p....Gs-sss+sRPKVNPFGDAKPREVlLpE+GKDWRKIDhELEH...RcV-RP...ETEEEK.LKEEIppL+tcLccppuh..p.ttstp-.......ptls-hIpphE+pL-hLshELDsKVRF........G.+.hpRPGSGAuRsusaspps.scupsh-sp..ht.M-RPRSRGssDshs+PsD-.RpuFQGS+..ERG	......................................................................................................................................................................................................................................................................................t....................................pu-..tpW...+.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	19	56	75
+6103	PF06275	DUF1031		Protein of unknown function (DUF1031)	Moxon SJ	anon	Pfam-B_11618 (release 9.0)	Family	This family consists of several Lactococcus lactis bacteriophage and Lactococcus lactis proteins of unknown function.	19.90	19.90	19.90	119.10	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.66	0.72	-3.94	2	29	2009-01-15 18:05:59	2003-06-03 13:04:35	6	1	24	0	3	21	0	79.00	63	97.37	CHANGED	Msthph.shhKL.sLAhpsphs.satp.SVhIosRTKtsHELsplYhDIpshaNpuKpMpWspLaphh.KpLTcsh.l..	.MlKTNFlTLKKLaGLA+NNNasss+K-LSVKISGRTKaNHELSQLYLDICNKYNHSKQMKWp-LYKIL.cELTcshtI-..	1	1	1	1
+6104	PF06276	FhuF		Ferric iron reductase FhuF-like transporter	Moxon SJ, Bateman A	anon	Pfam-B_11690 (release 9.0)	Family	This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.\	     FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B [1].  This family also includes the IucA and IucC proteins.	20.80	20.80	20.90	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.83	0.71	-4.28	156	3190	2009-01-15 18:05:59	2003-06-03 13:08:12	7	11	1404	17	525	1984	20	162.10	18	31.46	CHANGED	ptWhppYhphhlsPllthh..hpaGlsh.......psHhpNhllhhpst.GhPsp..hhh+Dhtsthhh.st.......h.............t.tt..hh.....p.hhpphhhslhhsplt.lhstLsp........stlscpthWphltphlpthhpphsphttt............hhtthhhtsslstcs.......................Rhtstsptts	....................................................................................tWhppYhphhl..Pllthh...hpaGluL..........-sHh.QNhllth.......cp.........G.....hssp....hhl.+Dhpst.hh.hhpt......................................................................t.ps...hhht....p.hhpphhtsl.....l.spLttlltslsp.......t..ssls...EphlWphltphlpphhsp.hsphssp....................hthhc.h.h.t..p.hshct....................th.......t....................................................................	0	119	287	418
+6105	PF06277	EutA		Ethanolamine utilisation protein EutA	Moxon SJ	anon	Pfam-B_11716 (release 9.0)	Family	This family consists of several bacterial EutA ethanolamine utilisation proteins. The EutA protein is thought to protect the lyase (EutBC) from inhibition by CNB12 [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	473	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.58	0.70	-5.89	19	699	2012-10-02 23:34:14	2003-06-03 13:13:58	6	2	662	0	49	1989	1083	442.30	60	97.76	CHANGED	cp.lhSVGIDIGToTTQLlFS+LplcNhAushsVPRlpIl-KEllY+SslhFTPLhspstIDsctl+pllcppYcpAGIs.psIcTGAVIITGETARKENAppllpsLSuhAGDFVVATAGPcLESIIAG+GuGAtphSc-+pssVlNlDIGGGToNlAlFcpGclhsTuCLclGGRLI+hDs.stclsYIuPthcpllcchulp..lplGspsshpplpplsctMsphLhpslshp.hoshhphLhhsc............slss..stplcs.....loFSGGVA-tlYpptpt....-.FcaGDlGhlLGpAl+psshhp..phplhpssETIRATVlGAGsHTsplSGSTIhhs.p-.hLPl+NlPVl+hst--ct.s..pslspulppplshFcl..csppptlAlAhsGptsssatplpslApulhpuhpphhppphPLllVl-pDhuKVLGpsLhshLshptsllCIDulplpsGDYIDIGpPlhsGpVlPVllKTLlFs	..................................................................................................................................+.pLLSVGIDIGTTTTQVIFS+..LELs.N......cAuVSpVPRaEhIcR-IsapSPVaF..T...PlccQutlcpscLKsLIL..c..QYp.uAGI.sP.EuVDSGA.lIITGESAKp..+..NARssVhALSpSLGDFV..VASAG.P.H.L...ES.V.I.A..G.+GA.G..AQ.o...L..S..E..Q..R..h..C.R.VLNIDIGGGTuNYALFD.AGKlSGTACLNVGG.....R.....L..........LE.....TD......u....QGR....V.......V...Y.....A.....H..p..P..G..Q...h...I....l.....D..E.....s...F...G...u.......G....T...-....u....+....u....L...o....u.u....Q..L......s......Q..V........s....R..R.....M......A.....p.....L........IV.....EVIsG...s.......L...S....PL....AQ...u.L...M..Q..T.s............LLPA....sls...P.El.....ITL.S.GGVGECYRpQPA.......DPFCFuDIGPLLATALH-HPR..LR......EMNVQFPAQTVRATVIGAGAHTL..SLSGSTIWLE..sV.pLPLRNLPVslPh--.......................pDLssAWpQALh...Q.LDL..-PcTDsYVLALPAoL.PVRYAAlLTVIsALlcFVA.Ra..PNP+.PLLVVAtQDFGKALGMLLRPQL.......Q.L.PLAVIDEVhVRuGDYIDIGTPLFGGSVVPVTVKSLAFP..........................................................................................................................................................................	1	24	36	43
+6106	PF06278	DUF1032		Protein of unknown function (DUF1032)	Moxon SJ	anon	Pfam-B_11729 (release 9.0)	Family	This family consists of several conserved eukaryotic proteins of unknown function.	23.70	23.70	25.10	24.10	22.30	23.30	hmmbuild  -o /dev/null HMM SEED	565	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.85	0.70	-6.03	4	230	2009-09-11 13:33:15	2003-06-03 13:15:43	6	10	116	0	163	219	1	251.70	20	56.13	CHANGED	MNFhEAALLIQGSAClYSKKVEYLYSLVYQALDFISsK++s+QhousspDGspcsss..APppsEp-FhuLDDlssscs....NVDLKcDphssslhIlPLhP.ALVsP-EhEKpssPLhSppGElLASRKDFRhNTChPpPpGsFhL-.lGhs.hpslp.h........httsQ+-.scuEppPMEl..S.susPs.s.phSpE...tsEussssGGh....-E-A-sGAE........thtlEssE.hppcpushpsRtYhLR-R.ptssEssupLpETPDPWpsLDPF-Sh.EsKPF+KGKsYoVPsGl-E.hsupKRKRKGssKLQDFtpWa.sAah-ts-ucRuRRKGPTFADMEVLYWKHlKEpLcs.RphpRRcusp.....paLsctEptlhPlEE-RlEDslE....s.GsADDa.-sE.....-hsE.stus.spEsA..Dl-s.sh.spLpYEELV+RNV-LFlssS..........QKasQETtLSpRlR-WEDsIpPhLQEQEpHssFDIHpYGDplsupaSplspWpsFApLVAGp.saEVCR.MLASLQLANDYTVEloQpPGL-suVDTMuLRLLTpQRAHpRFpTYsAPShsQ.	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lttWp..h...L.......p..p..apht..sp.hht.h.........................................................................h......................................hsp.h.s.L.h....................................................................................................................................................................................................	0	66	97	134
+6107	PF06279	DUF1033		Protein of unknown function (DUF1033)	Moxon SJ	anon	Pfam-B_11732 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins. Many of the sequences in this family are annotated as putative DNA binding proteins but the function of this family is unknown.	25.00	25.00	62.50	62.30	23.20	21.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.84	0.71	-4.29	16	683	2009-01-15 18:05:59	2003-06-03 13:18:02	6	1	679	0	40	200	0	112.80	45	97.96	CHANGED	MYpVlchhGDaEPWWFh-sWp-DIlppppF-sap-AhpaYpphW.chcppaspapo+pshhsAFWNpsDpcWCE-C-EsLQpY+SlhLLpspcsh.s..phh.thtppst....t..Cplpt	..MapVlcMaGDaEPWWFh-sWpEDIVppppF-sa.DAhKaYpphW.chcppas.Ypo+pshhssFWsspDp+WCE-C-E.LQpY+SLhLLpsp.pVl.s.ppht.hhphpst.....t...Cph..h...............	0	6	15	30
+6108	PF06280	DUF1034		Fn3-like domain (DUF1034)	Yeats C, Moxon SJ	anon	ADDA_1269	Domain	This family consists of several domains of unknown function which are present in several bacterial and plant peptidases. This domain is found in conjunction with Pfam:PF00082, Pfam:PF02225 and is often found with Pfam:PF00746. This domain has a structure similar to an Fn3 domain [1].	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.68	0.71	-3.66	47	863	2012-10-03 16:25:20	2003-06-03 13:19:24	7	76	562	3	234	844	9	117.40	23	8.11	CHANGED	lsLpph.ssp..hsFslsl+NhuspshoYplsst.....shTch.....s..ppGhhhtstts.t....................shshsssslTVsAsuotslslslss.sthtt....................pshalEGalphpsscss..............plolPYh	.....................................................lsLtpl.scp...hpaslpl+N.hus...p..s..hTaplssp........shT-t.............s...pps.p.h..stp..t.hs..................................shshs.tsslTlsAsuo.tslssslsssp.s.hsp.......................sh.alE..G.FlpFpuspst..............slolPah......................................................	0	57	142	195
+6109	PF06281	DUF1035		Protein of unknown function (DUF1035)	Moxon SJ	anon	Pfam-B_11733 (release 9.0)	Family	This family consists of several Sulfolobus and Sulfolobus virus proteins of unknown function.	25.00	25.00	46.10	43.70	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.67	0.72	-4.19	8	29	2009-09-11 12:40:51	2003-06-03 13:21:24	7	1	15	0	1	33	0	63.20	65	61.94	CHANGED	VLFsPIlSpVN.LTTstoaTTh...SGTl..TposhlsNPQYVGSSNATlVsLVPlFYLLVLIIVPAVluY+lYKpE	VLhssIhSpVNsLT...........SGTs..........PphsGo.NATLlsLVPLFYlLVLIIVPAVlAYKIYK..c..	0	0	0	1
+6110	PF06282	DUF1036		Protein of unknown function (DUF1036)	Moxon SJ	anon	Pfam-B_11760 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.10	21.10	21.50	21.40	20.70	18.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.72	0.71	-3.77	23	269	2009-01-15 18:05:59	2003-06-03 13:24:19	6	4	205	0	101	224	15	113.00	37	65.94	CHANGED	sApA-aclCNpTsshVslAlGY+sss..uWsoEGWWplssssCpsl.lpGsLssRaYYlYApDss....tts....pWsGchphCsp-.scFsI..tGsp-ChsRGapcsGFtElDTup.ppsWTlpLT-	...........................ApADh+lCNsTpshVulAlGY..+s.ts......uWsTEGWWplss.usCcTl...lcGs.L.s..uRYYYlYAcDsp.............tuu........pWsGp..s.phClt....-...pcF.pI...pGsp...D...ChuRGap+sGFtEhDTuc.ptsWhlpLo............................................	0	25	55	70
+6111	PF06283	ThuA	DUF1037; 	Trehalose utilisation	Moxon SJ	anon	Pfam-B_11803 (release 9.0)	Family	This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose [1]. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium [2].	31.90	31.90	32.10	31.90	30.90	31.80	hmmbuild  -o /dev/null --hand HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.44	0.70	-4.63	91	1197	2012-10-03 00:28:14	2003-06-03 13:27:10	6	87	601	10	469	1171	683	219.50	23	52.37	CHANGED	+lllascs.tthpp....h..h..............shtssltphhpt....stthpssshp-..tpshsc.....pp..........LsphDlllhhsst...t..............sc.phtpslpcaVt.sG.tGllslHsuthsth............p..........apc.lhG................................................................................................................................................uphphHs...........stpphplh..lhsssHPlspGl...s.pt.....................aph.p-EhYshph.hPpss....pVLhoh..............................tsGcsashuashph..............................GtGRlFYpshGH......p..........sh.sa.pssshpphlhsulpWAs	....................................................................................hlhtt....tt..pt....p...h..............shtttltp.hhp...............ttsh..p..s..s..s..t...p..s....p..s...hsp............................pp..........L.s..p.hDl.llhhsst........tpt.........l.........................ss..pth....pt.....l....tph....lp.sG.tGllslH.u.s....hs..sh............................p..................app..lhG..................................................................................................................................................u..t.h....pt....Hs...............shpphplh........lh...s..s.....s..HPlsp..Gl.......pp.................................aph..p-E.hYs..hph...sPp...t..............hpl..Lhshp..................................................tsup.s..aP.....huWsh.ph..............................GtGRlFYsshGH.........................p................st..sa.p.ssshpphlhsulpWu................................................................	0	213	376	431
+6112	PF06284	Cytomega_UL84	Cytomegalo_UL84; 	Cytomegalovirus UL84 protein	Moxon SJ	anon	Pfam-B_11948 (release 9.0)	Family	This family consists of several Cytomegalovirus UL84 proteins. The open reading frame UL84 of human cytomegalovirus encodes a multifunctional regulatory protein which is required for viral DNA replication and binds with high affinity to the immediate-early transactivator IE2-p86 [1].	25.00	25.00	74.40	32.90	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	530	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.70	0.70	-6.09	4	46	2012-10-03 01:18:03	2003-06-03 13:30:03	6	2	15	0	0	42	0	419.40	53	97.45	CHANGED	MPRAD.TLRNtsR.uRsRKus.............................................................................h.sD-TILTLTDpHclKpPLs++GTY+LIQLHlDhpPp-LQHPFQILLSsPLQL.....................................Es.ss+pDscERGlLCsVuNtDSDIhPshSLFPApsG.CpIlRulIDpQLTQMuIVRLSLNlFAL+IhsPLh+pLPLRRKsspHsALHDCluLHLP-LTFps...............Dts.sscss.TPpLTlpV+pALCWHpsEGGISGPRGLTSRISVRLSEuThpshGPulFGpL.hDs.-SP.DLsLSSLhLYQDslLRFNVThcsuppphPSsP.VSFRLRLRRcTVpRPFFSDsPLPYFlPR+ps..ssGL-VplPY-LoLKsSHhlRIYRRFYGPaLGLFlPHNRQsLpMPVTlWLPRTWLEIoVlssssH...................................lP+soVLGpLYFISSKHTLNRGpLSALTaQVKSuLHspP.......pQLSlLGASluLQDLlPMRlusP..-PpsppQQpssTppspPVTlAMVCsch	......................MPRsD.sLRNtsR.sRsR+s.............................................................................h.tsspTILTLTDpHcl+pPhs+cGTY+LIQLHlDhpPp-LpcPFQILLSTsLQL.....................................Es.ss+pDscERGlLCsVuNpDSDlhPuhSlFPApsG.CpI.lRulIDpQLTcMuIVRLSLNlFAL+llsPLl+pLPLRRK..sscH..TALHDCluLHLP-LTFcs....................s-ts.TspLTlp.V+p.ALCWH..psEGGISGPRGLTSRISsRLS-sThpsLGP....ulFGpL.hDs.-SP.DLsLSSLhLYQDshLRFNV.....T..ssppphPusP.VuFRLRL.RRpTVpRPFFSDsPLPYFlPs+ps..stGL-VplPY-L..oL..KsSHpLRIYRRFYGPaLGlFVPHNR.QsLpMPVTlWLPRoWLEloVlssspp..................................phPRsslLGcLYFISSKHoLNRGpLSAhsHQVKSo.LHups.......p.QLSlLGASIuLpDLlPMRlusP..pPps..pp.ppssTp.spPVTlAMVCsp.h................................................	0	0	0	0
+6114	PF06286	Coleoptericin		Coleoptericin	Moxon SJ	anon	Pfam-B_11996 (release 9.0)	Family	This family consists of several insect Coleoptericin, Acaloleptin, Holotricin and Rhinocerosin proteins which are all known to be antibacterial proteins [1].	25.00	25.00	30.70	30.60	23.50	18.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.90	0.71	-4.29	3	16	2009-09-10 22:13:49	2003-06-03 13:36:34	6	2	8	0	2	17	0	111.00	48	95.23	CHANGED	MMKLYIlFGLIAlSAAYVVPEtYYEP.YP-sAua-utRlEP..lSPAEL+aspslsDEsEl-.P.hYIRERRSLQPGAPNFPMPGSQLPTSITSNVEKQGPNTAATINAQHKTDRYDVGATWSKVIRGPGRSKPNWSIGGTYRW	......................................................................................................................................RRSLQPGAPNhs..spp.P.h.plossluR.p.s.s.NTpusINlQ+KG-saDhsAGWSKVlRGPsKuKPTWHVGGTYRW.	0	2	2	2
+6115	PF06287	DUF1039		Protein of unknown function (DUF1039)	Moxon SJ	anon	Pfam-B_12079 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins from Escherichia coli and Citrobacter rodentium. The function of this family is unknown.	25.00	25.00	26.70	26.90	20.10	18.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.07	0.72	-4.08	5	254	2009-01-15 18:05:59	2003-06-03 13:44:08	6	1	241	0	11	57	0	65.90	55	72.96	CHANGED	lAAVNHuLhupAHAILNALPplIPDccsptlCEAlLLFGLN-pscAs+tLAs.hssE-AQsLRuLls	..hAGVNHuLhups+AhLsALs.IlPDKKlpLlC.AlLLhGLN-.hcAsKlLuD.hD..-A.hLphLh.......	0	2	5	8
+6116	PF06288	DUF1040		Protein of unknown function (DUF1040)	Moxon SJ	anon	Pfam-B_12122 (release 9.0)	Family	This family consists of several bacterial YihD proteins of unknown function [1].  	20.80	20.80	21.20	21.30	19.10	20.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.66	0.72	-3.75	15	736	2009-09-11 13:49:48	2003-06-03 13:47:46	8	2	731	1	66	206	2	85.40	78	96.16	CHANGED	MKCHRlNELlELLpPtWp.K-P-LsLlphLpKLApEuGapGsLs-LTDDVLIYHLKMRso-KsEhIPGLKKDaEDDFKTALL+ARGl	........MKCKRLNEVIELLQPAWQ.KEPDLNLlQFLQKLAKESGFDGcLsDLTDDILIYHLKMRDSAKDAsIPGLQKDYEEDF..KTALLRARGV.........	0	5	21	45
+6117	PF06289	FlbD		Flagellar protein (FlbD)	Moxon SJ	anon	Pfam-B_12586 (release 9.0)	Family	This family consists of several bacterial FlbD flagellar proteins. The exact function of this family is unknown [1].	20.60	20.60	20.60	21.40	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.66	0.72	-4.60	55	409	2009-01-15 18:05:59	2003-06-03 15:07:04	6	1	404	0	147	323	3	59.70	43	81.93	CHANGED	MIpLTRLNGc..pFhLNu-hIEpIEssPDTsITLssG+KalVpEss-EVlc+llpa+pcIht	....MIplT+L..NGp.....tFhLNschIEplEp..sPD.TsITLssG+Khl.........VcEos-EVlc+lhpa++clh.h......	0	75	120	133
+6118	PF06290	PsiB		Plasmid SOS inhibition protein (PsiB)	Moxon SJ	anon	Pfam-B_12789 (release 9.0)	Family	This family consists of several plasmid SOS inhibition protein (PsiB) sequences [1].	20.60	20.60	21.80	26.90	19.50	18.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.74	0.71	-4.77	5	311	2009-01-15 18:05:59	2003-06-03 15:14:08	6	3	206	4	8	165	0	137.20	79	96.56	CHANGED	MKTlLTLsVLpTMoupEhEDaRsAGEDhRRELSHAVMRDLTsPuGWsVNAEYRSEFGGFFPVQlRFTPuH.-+FcLAVCSPGDLSPhWllVFlosGGQPFSVVpshcsasPEtIoHTLuLlAsLDAsGYShASIIolLutEGuQ	.....MKTELTLNVLQTMNAQEYEDIRAAGSD.RRELTHAVMRELDAPsNWsMNGEYGSEFGGFFPVQVRFTPAH.ERFHLALCSPGDVSQlWh.LVL.......VNuGGcPFAVVQVQ+tFuPEAlSHoLALAAoLDAQGYSVNDIIHILMAEGGQ...............	0	1	1	5
+6119	PF06291	Lambda_Bor		Bor protein	Moxon SJ	anon	Pfam-B_12850 (release 9.0)	Family	This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the Escherichia coli host cell in animal serum. This property is a well known bacterial virulence determinant indeed, bor and its adjacent sequences are highly homologous to the iss serum resistance locus of the plasmid ColV2-K94, which confers virulence in animals. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis [1].	21.90	21.90	23.10	22.20	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.97	0.72	-10.15	0.72	-4.06	2	335	2012-10-01 23:27:00	2003-06-03 15:22:13	6	3	252	0	24	139	10	94.10	75	96.65	CHANGED	MKKMLhusALAhLITGCAQQTFTVtNK.TAVsPKETITHHFFVSsIGQ+Khl.tsKhsGGsENVVKTETQQTFVNuL.GFIThGIYTPhEsRVYCSQ	....................................................MKKMLhus.AL.A.h.LI.TGCAQQTFT..Vt....N..K.PT...A...V..s..PK...E.T..I..TH.HFF..V..S..GI.GQ.cKTVDAAKICGG.A.E.N.VVK.TETQQTFV.NGLLGFI..T..LG.IYTPLEARVYCSQ...........	0	5	10	14
+6120	PF06292	DUF1041		Domain of Unknown Function (DUF1041)	Yeats C, Moxon SJ	anon	ADDA_1192	Domain	This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with Pfam:PF00168, Pfam:PF00130 and Pfam:PF00169 domains.	20.70	20.70	20.70	21.00	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.36	0.72	-3.87	13	481	2009-01-15 18:05:59	2003-06-03 16:54:33	12	20	88	0	229	460	0	98.60	43	7.23	CHANGED	psVV+cClcsshpssYphlhspsp..hsp..t.....................tphs..ppssss+pL-.hh+LhpLslsllppsccpYu.shpt.Fs..hslhp.pAEshWoLFusDMctALEtp	.....................................ppVV+cClctsh.ssYphlhp.s+..hspt.t..........................t..c.hs......cp.sssh+pL-.h.+LhpLh..lpllpps....cppas..............s..........h.........pt.Fs...slht.pAEshWsLFA.DMchALEtp..............	0	50	65	143
+6121	PF06293	Kdo		Lipopolysaccharide kinase (Kdo/WaaP) family	Studholme DJ	anon	Krupa A, Srinivasan N	Family	These lipopolysaccharide kinases are related to protein kinases Pfam:PF00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is  necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.23	0.70	-5.26	14	2201	2012-10-02 22:05:25	2003-06-03 18:59:37	9	20	1403	0	513	8874	747	187.20	22	64.55	CHANGED	spaWttpucslspspGRtssWFs.tph....pssh++YaRGshhu+ls+D.atas.hspspuhtEFpllccLcctGlsVP+slAushh+huht..apA.lLoEclssspDLsshltp.......tphppthhctlGphItchHpsslsHsDLss+sILlctpt....t..chhlIDh-+sthph..ss+WppcsLspLhRSh........slthscpDattlhpuY	..................................................................................................................................................t.................h.ht..hhhtt..h....t....phhp.s...h...h......h....s......h.........t.......sh..+Eap.hl..cc...L.p...c.....h...G....l...s..s.....s....p..s....l..u....h...t....t...t.....t....h.....s....s.........h....p...u....h...l....l..T..E.......c.l.......s....s.....s....h...s...lps.h..h.t..p........................psp.h..p...p..........t......l...l........c....t...l.u....p..h....l....t.ch...H.t.s...s.lpHs...Dhhl..pplL.l.+tst.............................thchh...lI..Dh...c..+...up......h.....+..h........t....spc...h..p....p...c..D.L..h.tL.h...................h...t..t...h..h.......................................................................	0	135	275	414
+6122	PF06294	DUF1042		Domain of Unknown Function (DUF1042)	Yeats C, Coggill PC	anon	ADDA_2448	Family	Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum [1]. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear [1]. Transcription aberrations leading to a truncated protein result in immotile sperm [2].	25.00	25.00	25.50	25.80	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.90	0.71	-4.64	6	395	2012-10-03 10:10:54	2003-06-04 11:42:13	6	13	119	1	270	374	4	139.10	24	23.64	CHANGED	LspWLpp...lspolss+shsRsFSsGhLlAEll++aaPp.lDhpsassusSlphKLsNWupl.pKsLsKLshplscslhcplhsspPGssEhLLapLhthL...p+pcppulsshptpshp.posh+h.slpppshp-ulhphhpp....u..p.lcpstslt	..............................lhpWlpp....lsloh...+sh.p....R.D.F.SsG.hLl.AEllp.pa.h.Pphl-hcsass.u.sShptKlsNWspL.................c.............+s.......Lp+...L...s..h.p..ls.p.....p.hhcsl..h.psp.s.Gsspt....lL.hpLhttl..........ppp...p...t.t....t......................................................................ttt.....................................................................	0	107	137	206
+6123	PF06295	DUF1043		Protein of unknown function (DUF1043)	Moxon SJ	anon	Pfam-B_12007 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	28.80	28.80	29.10	28.90	27.80	28.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.71	0.71	-4.50	5	884	2010-01-13 14:53:39	2003-06-04 14:20:45	7	2	879	0	118	373	38	126.10	54	92.06	CHANGED	YAlIGLlVGlIIGhlIsRLTssplKpQpslcKELEsuKtEL-pQRpELpDHFAcSAELL-TLu+DYpKLYQHMAKoSssLLPpLstpsNPFspptt.ps-cSNspE.....lppQPRDYupGAoGLl+spcKc	........................YALIGLVV.GI.IIGA.V...A.MR.F......G.NRK.....L......RQ....Q..p....uLQ.hELE.....K.sKsEL-EYRpELVoHFA+SAELLDTMA+DYRQLYQHMAKSSosL.L..P...E..l.s.s........c.....s.NP.F+.sRLs......E.....S...EA..S....NDQu............PV.ph.PRDYSEG.AS.GLLRsttK.c...........................................................	0	20	48	87
+6124	PF06296	DUF1044		Protein of unknown function (DUF1044)	Moxon SJ	anon	Pfam-B_12045 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.46	0.71	-4.27	36	879	2012-10-03 00:18:00	2003-06-04 14:22:33	7	2	693	0	167	538	38	103.50	27	90.35	CHANGED	MRlFKs+hFs+aA++ct.lsDpsLtcAlcchtpGhlDADLGGGVhKKRlucs.GpGKpGGaRollha+t..uc+hFFlaGFAKs-p.u....NIoscEltsh+plApthhshocppLspLlpsttlhEl	............................................................................p..t....h.t....h.......t.h.........t.s...h....t.......s....L...G..G..G.....lhK..hR..l..s..ps..tp........GKpGGhR....sI......h.h.h....ps.....s.p.p.ha.a..h.h.hYuKs-h.s.....sIospEhtsh+phuphh..........................................	0	34	101	130
+6125	PF06297	PET		PET Domain	Yeats C, Moxon SJ	anon	ADDA_3209	Domain	This domain is suggested to be involved in protein-protein interactions [1]. The family is found in conjunction with Pfam:PF00412.	25.00	25.00	25.80	25.40	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.37	0.72	-4.38	18	570	2009-01-15 18:05:59	2003-06-04 14:23:54	9	11	111	0	287	491	0	98.40	44	17.57	CHANGED	phshpssssoccDssssp..pYsWsPPGL.s.chlppYhphLP--KhPhlGStGt+aRp+QLlaQLPsaDp-sphCcuL.s-cEt+phc.FspppKcEuL.GhGsV+hhs	...............h...hpp.shuccsssh.sh...pYtWsPPGl..p.c....sppYhp.h.L....Pc-KhPhssS.Gt....pa..R..h+QLhpQLPsHDp-sphC.ps.L...s.......-c.E.t.+Ehc.Fsp.ppKcEAL.GhGsV+...s.......................	0	56	76	170
+6126	PF06298	PsbY		Photosystem II protein Y (PsbY)	Moxon SJ	anon	Pfam-B_12212 (release 9.0)	Family	This family consists of several bacterial and plant photosystem II protein Y (PsbY) sequences. PsbY is a manganese-binding protein that has an L-arginine metabolising enzyme activity [1].	20.40	20.40	23.30	20.90	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.59	0.72	-4.43	22	176	2009-01-15 18:05:59	2003-06-04 14:34:32	6	4	112	0	72	159	18	35.00	45	49.48	CHANGED	MDhRlllVlhPIllAuuWAsFNIG+sAlpQlpp.hhp	........D.RlllVlhPll.AhuWsLFNIhpsALsQlp+.h..p.....	0	16	49	63
+6127	PF06299	DUF1045		Protein of unknown function (DUF1045)	Moxon SJ	anon	Pfam-B_12127 (release 9.0)	Family	This family consists of several hypothetical proteins from Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.	24.30	22.60	25.60	23.80	24.20	22.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.87	0.71	-4.56	43	281	2012-10-03 21:31:48	2003-06-04 14:48:08	7	3	253	0	93	273	102	158.20	40	65.60	CHANGED	TLKAPFpLAsGtstspLhsAspsFAtphsPhslstLtlsplGsFlA..LlPssss..ssLppL...AussVppFDsF...RAPhots-luRR+sstLospQcphLpcWGYPYVh--FRFHMTLTGpL...stsppstlhshLpstasslh..psltlsslALFsEsssGssFpl	..............TlKAPF+LAssto..pscLhAAhtpFAustsPhslstLplpp...l........u....uFhA....LsPspss......stLppLAsssVpsFDtFRAPho.-.A.E.l..ARRcsptLotcQcp.LtcWGYPYVh--FRFHMTLTG.l...stpcps...t..lppsLcphass.h.ls.psltlsslALFsEsptGuPFp..............................	0	13	48	65
+6128	PF06300	Tsp45I		Tsp45I type II restriction enzyme	Moxon SJ	anon	Pfam-B_12151 (release 9.0)	Family	This family consists of several type II restriction enzymes.	25.00	25.00	25.30	25.00	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.78	0.70	-4.94	3	36	2012-10-11 20:44:44	2003-06-04 14:53:36	7	2	22	0	3	35	5	222.00	67	99.39	CHANGED	Ms..NhWTcLSIEYANQRSYLDDLFQVYsTIP-SlRoIsEKlWSNVEcAFK....RKDN....LuLIcELLN....LDLFPIKDSYlA...YLK+DKo.....ALE........RNPRTINRICGRLYEMGLNKIaEKsSEPKETNRQIGPMFKcWh+cKSLG................VEP....VDLusFIANE-DAIL..cASDclMtDFAKEaLGYpHc.....KGLDFlARFN+o.....YlIGEAKFLTDFGGHQNAQFNDAIuTIEAc.sl+AIKVAILDGVLYIcupNKMaKulsohYK-aNIMSALVLR-F...LYQ.......L	...................................................M....NhWTchSIEhANQRsYLDcLFpVYPhIP-ulREIDuKlWSNlEYHFK....pKDN....LuLIsELLN....LDLFPIKDSYhA...YLKRDKS.....ALE........RNPRTINRICGRLYEMGLNKIFEKCSEPKETNRQIGPMFKcWlNNKSLG................VEP....VDLNDFIANEsDAIL..+ASDslMuEFAKoHLNY+Hc.....KGLDFlARFNKK.....YIIGEAKFLTDFGGHQNAQFNDAISTI-sP....NlKAIK.VA.ILDGVLYIcSNNKMpKhLs.TpY+NapIMSALVLR-F...LYQI..............................	0	2	2	3
+6129	PF06301	Lambda_Kil		Bacteriophage lambda Kil protein	Moxon SJ	anon	Pfam-B_12201 (release 9.0)	Family	This family consists of several Bacteriophage lambda Kil protein like sequences from both phages and bacteria. Induction of a lambda prophage causes the death of the host cell even in the absence of phage replication and lytic functions due to expression of the lambda kil gene [1].	23.70	23.70	23.90	23.80	23.40	21.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-7.95	0.72	-4.53	3	292	2009-01-15 18:05:59	2003-06-04 15:00:54	6	2	219	0	6	103	1	42.10	66	73.92	CHANGED	MDQoLMAIQoKFsIAsFIGDcKMaREAV-AaKcWI.h.hhRpK	....MDQsLMAIQoKFsIAsFIGDEKMaREAV-AaKcWI.l.hhRpp........	0	0	0	1
+6131	PF06303	MatP	DUF1047; 	Organiser of macrodomain of Terminus of chromosome	Moxon SJ	anon	Pfam-B_12243 (release 9.0)	Family	This family, many of whose members are YcbG, organises the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. Organisation of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localises with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organiser of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organisational system is required in the Terminus region for bacterial chromosome management during the cell cycle.	20.00	20.00	21.70	21.10	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.02	0.71	-4.29	13	737	2009-01-15 18:05:59	2003-06-04 15:36:37	7	1	719	0	67	231	1	145.90	71	97.72	CHANGED	MKYQQLENLEsGWKWpYLlKKHREGEsIT+alEpStA-suVppLlplEppPscV.cWIcpcMsPcLcN+hKQuIRA+RKRHFNAE+QHTRKKSIDL-YtVWpRLSthupchGsTLSETIshLl-EAE+KEpYucphSuLKpDL+cLLs	.................................MKYQQLENLESGWKWKYLVKKHREGELITRYIEuSAAQEAVchLLuL.....ENEPVhVssWI-cHMNP-LlNRMKQTIRARRKRHFNA.EHQHTRKKSID..LEFhVWQRLAGLAQRRGpTLSETIVQLIEDAEpKEKYAspMSSLKQDLQALL.G..............	0	5	19	47
+6132	PF06304	DUF1048		Protein of unknown function (DUF1048)	Moxon SJ	anon	Pfam-B_12247 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	29.60	29.60	29.60	30.10	29.10	29.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.21	0.72	-3.71	16	339	2012-10-01 22:34:14	2003-06-04 15:38:59	6	1	278	4	47	204	1	101.10	38	82.38	CHANGED	ppsl-pK+Ea+tacsRscsLPcDYptsaccIp+YlaphG.sschtshhtIhssll-LFEcuAA-G+sVt-llG-DVAuFsDpLls-sts..atDKaR-pLNcsls	...................t.Khls-KKEY+thh.tRl.tALPpDYphlaccIppYhWp.Fu..stsGtsM....hplhp-llDLFEpuAA-Gpplh-lsG-DVusFADpLlssst...s...as.cK.+ccLNcpl...............	0	25	39	44
+6133	PF06305	DUF1049		Protein of unknown function (DUF1049)	Moxon SJ	anon	Pfam-B_12262 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  --amino -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.13	0.72	-4.50	84	2233	2009-09-13 05:33:55	2003-06-04 15:41:11	6	3	2122	0	510	1349	240	65.60	24	60.14	CHANGED	hpNsphVslsalhupsp..hsLulllhhsFshGhllGh.Lhshhhh..h+h+hphpphp+......plpphppplsp.p	...........................pNs.p.Vshsa..l.h......s...p.sp....h.........sLs...l..l..lh..sshs..hGhllGh.llshhhh.......h+.h+h....pl.tchp+.......clpphppp.....t...................................................	0	138	316	417
+6134	PF06306	CgtA		Beta-1,4-N-acetylgalactosaminyltransferase (CgtA)	Moxon SJ	anon	Pfam-B_12320 (release 9.0)	Family	This family consists of several beta-1,4-N-acetylgalactosaminyltransferase proteins from Campylobacter jejuni [1].	20.20	20.20	20.30	21.00	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.27	0.70	-5.23	2	149	2012-10-03 05:28:31	2003-06-04 15:48:29	6	3	96	0	12	116	1	256.00	46	86.71	CHANGED	MLFQSYFVKIICLFIPFRKIRHKIKKTFLLKNIQRDKIDSYLPKKTLlQINKYNNEDLIKLNKAIIGtGHKGYFNYDEKSKDPKSPLNPWAFIRVKNEAITLKASLESILPAIQRGVIGYNDCTDGSEEIILEFCKQYPSFIPIKYPYEIQIQNPKSEENKLYSYYNYVASFIPKDEWLIKIDVDHhYDAKKLYKSFYIP+ppYcVlSYSRlDhha.p-pFalh+sppGpILKtPGDCLhIpNhNLhWKElLI-..sssaKhsTtps..pNh+ShE.LKh+pRIhFpTELNNYHFPFlKpaRtpDhhphNWlSl--FhK.YhpplpppI-.pMlphcTLKKlahpLh	......................................................................................................................t..........HpGaFsaDpcupssKSPLNPWAFIRVKNEulTLcsSLcShLPAIQRGVIGYNDC....sDGS.cEl...ILEFCKpYPS......FIPl.p.Y.....P...........Y...............El.....p.l..pN.....s.p.......S...-......c.N..p.LYs.......YYNYs..hSFIP......psEWlIKIDsDHhYDAKK..L..YK..SFYhs.cpph..csl.YsRlsFhh.stp...h..al.pstp.ht..hh.t..GDphll.s.s..a.E...................psh..shE.Lt.h+p.hhhh..p.sEL.paHFPhhK..Rptsh.ph.shlsl-..-F.hK..atc....ppIp.pMlpcchl.phh.p..h...................................................................................................................	0	6	8	9
+6135	PF06307	Herpes_IR6		Herpesvirus IR6 protein	Moxon SJ	anon	Pfam-B_12322 (release 9.0)	Family	This family consists of several Herpesvirus IR6 proteins. The equine herpesvirus 1 (EHV-1) IR6 protein forms typical rod-like structures in infected cells, influences virus growth at elevated temperatures, and determines the virulence of EHV-1 Rac strains [1].	25.00	25.00	105.90	105.80	24.10	17.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.50	0.70	-5.00	4	38	2009-01-15 18:05:59	2003-06-04 15:55:52	7	1	12	0	0	18	0	133.80	66	83.56	CHANGED	spustchh.Ns.sthlGhsYFRRCRpEhNEGaaApVPsGYFPVtPSphPshV.Vcu......hsGEsluFpslPsP+h-hRFaKQLpDGTFVRLPF.YP-EhYEsE.pPhtsRaYlpADscssSS....ssPSsLhEphFscVPsult.EthspWsGPK+lPlPscRYVLKhGaE..hp.pVTEDAFp.lsTphLRL-htst..................ss...sAt.s.ptspVpts	.ssssu.....sTGPGCEGGLGGWRLFKACRHEQEDGLYAMLPPDYFPVVPSSKPLLVKVPAPGASPDRTGGAVHFECVPAPRRPLQFFRQLYDGT........................................................................................................................................................	0	0	0	0
+6136	PF06308	ErmC		23S rRNA methylase leader peptide (ErmC)	Moxon SJ	anon	Pfam-B_12332 (release 9.0)	Family	This family consists of several very short bacterial 23S rRNA methylase leader peptide (ErmC) sequences. ermC confers resistance to macrolide-lincosamide streptogramin B antibiotics by specifying a ribosomal RNA methylase, which results in decreased ribosomal affinity for these antibiotics. ermC expression is induced by exposure to erythromycin [1].  	25.00	25.00	53.40	53.40	17.10	17.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.96	0.72	-7.11	0.72	-3.90	3	48	2009-01-15 18:05:59	2003-06-04 16:01:11	6	1	29	0	4	15	0	27.50	96	98.65	CHANGED	MLVFQMR....NVDKTSTVLKQTKNSDYADK	MLVFQMR....NVDKTSTVLKQTKNSDYADK	0	1	1	1
+6137	PF06311	NumbF		NUMB domain	Yeats C, Bateman A	anon	ADDA_13736	Family	This presumed domain is found in the Numb family of proteins adjacent to the PTB domain..	19.90	19.90	20.60	20.60	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.25	0.72	-3.88	8	177	2009-01-15 18:05:59	2003-06-05 14:09:23	7	4	74	0	80	195	0	86.40	63	15.01	CHANGED	sPaAIPRRHAPs-.LhRQGSFRGFsulupp.......SPFKRQLSLRlN-LPSThQRpp................-hpspsPlsEhEst..uts......D.SISuLCsQIosuFS	................PaAIPRRHAPlEQ..LsRQGSFRGFPALSQK.......SPFKRQLS....LRlNELPSThQR+T.........................DF.lKss.V..P..ElE......G-u............-.SISuLCoQIosuFu............................................	0	16	22	47
+6138	PF06312	Neurexophilin		Neurexophilin	Moxon SJ	anon	Pfam-B_12369 (release 9.0)	Family	This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins [1]. 	20.70	20.70	21.00	20.90	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.63	0.70	-5.10	6	508	2012-10-03 16:25:20	2003-06-05 14:41:06	7	8	43	0	338	454	0	177.90	29	47.06	CHANGED	Rlht+cssssssshtp.oshtss.........p-aWDhLus.o-lpt........s.sRsKR+Pll.pTGKhKKhFGWGDF.aSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGpGNVSVSLVPPSKlVEF-lpQQhhlEsK-SKs.FNCRlEaEKlD+upKTuLCsaDPSKlCaQ-QTQS+VSWhCSKPFKllC.lYIuFYSsDY..+LVQKVCPDYNYHS-TPYhsSG	.....................................................................thht............................................................................................................t...Kha..G.GDF.pup.l.p.o.....s....p.....L....p.....h....h..ss..G+l.s.D.asNGTapV.Fph.hsGps.sl..SVpLV.PScuVph....................................p........ph......h...c.t.p...s+s....Fps.p.h..c...........t.p.....s.p..c.s...p..c..s....s......l...s...................s.......s......s.......p......h...Cphppsps...ptsWhC.KP..h..+..l...C...hl.s..ah.p.st.......................................................................................................	0	100	120	202
+6139	PF06309	Torsin		Torsin	Moxon SJ	anon	Pfam-B_12047 (release 9.0)	Family	This family consists of several eukaryotic torsin proteins. Torsion dystonia is an autosomal dominant movement disorder characterised by involuntary, repetitive muscle contractions and twisted postures. The most severe early-onset form of dystonia has been linked to mutations in the human DYT1 (TOR1A) gene encoding a protein termed torsinA. While causative genetic alterations have been identified, the function of torsin proteins and the molecular mechanism underlying dystonia remain unknown. Phylogenetic analysis of the torsin protein family indicates these proteins share distant sequence similarity with the large and diverse family of (Pfam:PF00004) proteins. It has been suggested that torsins play a role in effectively managing protein folding and that possible breakdown in a neuroprotective mechanism that is, in part, mediated by torsins may be responsible for the neuronal dysfunction associated with dystonia [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.65	0.71	-4.25	8	383	2012-10-05 12:31:09	2003-06-05 14:44:56	6	6	102	0	205	556	182	119.00	39	36.68	CHANGED	ChFt-CCs...-scIshshpuL-pDLsspLaGQHLspclVV+olKualpss.pPpKPLVLSFHGaoGTGKNaVucIIAcNhYRsGL+SsaV+hFlAThcFP+sppl-pYKhcLpsplppohptCpRSlFIF	.........................................C.h.th.Ct......pp.....s..hp...........uLcp-Lpp+LaGQHLApc........l..l........lpAl.p.u.a.......l...s.s.......p.PcK..P.L.s.L.S.hHGaoGTGK....N....aVupllA..csl...a.p.p.G.......h.c.SsaV+...hFlu.s.......hH....FP.Ht..p..plp..h..Y.......+............cpLpphlpsslstCsp.SlFlF..................................................	0	48	64	114
+6140	PF06313	ACP53EA		Drosophila ACP53EA protein	Moxon SJ	anon	Pfam-B_12718 (release 9.0)	Family	This family consists of several Drosophila ACP53EA accessory gland (seminal) proteins.	25.00	25.00	34.90	30.30	19.40	22.50	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.30	0.72	-4.05	6	87	2009-09-10 23:46:03	2003-06-05 14:46:14	6	2	13	0	18	93	0	90.20	30	76.51	CHANGED	asKhhcCscVus-ulupLlcpsIPsVppLtpCsDY...pPtpsKspShltal+lsYpFhKKhlhccPcCLlhhlspussLl+Pahcpl-oLpClsE	....hp+hLcCscluhcususLhpcsIPsl+pLtpCssF...pP..pst..sh.shhthlclsYpFl++.lh.sp.cCLlsslpchhshlpPalppl.shpCh.....	0	4	4	11
+6141	PF06314	ADC		Acetoacetate decarboxylase (ADC)	Moxon SJ	anon	Pfam-B_12720 (release 9.0)	Family	This family consists of several acetoacetate decarboxylase (ADC) proteins (EC:4.1.1.4).	29.80	29.80	29.80	29.80	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.49	0.70	-5.02	72	670	2012-10-01 19:21:02	2003-06-05 14:46:38	6	12	525	20	280	644	110	225.10	20	74.15	CHANGED	shPl.hss....shs............st-hlhlpYcTDscslppllPt.sLclsp.......slVth.hhchssso.uhh..........sYpEsu.sl.Vp.ap................Gp....p.GsYshhhalD...scsslsuGRElhGaPKKlup.plpp.............s.ssslsGslch.suhplspsshshctps.s..tshtthpt...........s.hhh+hlPs.hsu.tsp...lscLVphthsshsht......tsasGs.usLpL.tsp.shssls..........pLsl.hclluuhahhsshs......lshsphlhc............L	.....................................................................h...............................stphhh..hh..apss.ct...l..p...pl.l......P.........t....s.....Lchsp...............slVt...h..hh..c..hs.css..u..................sYsEhuh...s.l.....Vp..ap.........................sc...............t.usa..shthhlc...sp.slsuGREl.aGaPKphAs.hs.lpp.........................................pssphtusl...sh...su.....htlsphshshtt...s......h..htt.....................hhhchlsp....ss....................hsphl.h...hpsh.th.................thh.Gs..uplpl.......t..............t.h.t.ls..........pLsl..hch.l...tu.hh.....................................................................................................................................	0	83	180	237
+6142	PF06315	AceK		Isocitrate dehydrogenase kinase/phosphatase (AceK)	Moxon SJ	anon	Pfam-B_13100 (release 9.0)	Family	This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (AceK) proteins (EC:2.7.1.116) [1].	20.80	20.80	20.80	27.90	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	562	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.86	0.70	-6.23	39	830	2009-01-15 18:05:59	2003-06-05 14:47:17	6	3	792	6	133	519	192	541.90	62	96.03	CHANGED	lAcsILpGF-paathFpplTttAcpRFEpuDWpulQpAs+cRIphYDc+VppssppLcp....hsspths..............tshWtplKptYhsLlhs+.p.ElAETFFNSVhs+lac+phhps-hlFVpsshs....csc..sh.pshh+sYhss.....ssLppslpcllp-ashphPa-DLpRDlphlhptlppphss.......hthssshplclLpslFYRNKuAYlVG+lhs..ssp.....hPFll......PlLpscsG...tLhlDslLhspsclullFSFuRuYFMV-sphPuuhVpFL+sLhPpKspuELYoulGhtKpGKT.FYR-hlpHL.cpS..sDpFllAPGIKGMVMhVFTLPSasaVFKlIKD+FussKpho+....tpVpsKYpLVKpHDRVGRMADT.EasslsFP+pRFSs-LLpELpphsPSplc...hpGD....pllI+HLYlERRMsPLNlYLcpAs-p.........p....lcpAlpE....YGpAIKpLAAANIFPGDMLhKNFGVTRHGRVVFYDYDEIpYlT-sNF.RplPtPcp.E-E...........huuEsWYSVuPpDV..F.PEc.FshFlhussplRchFhchHu-Lh-ssaWpshQppI+pGpltDVaPYcpptR	......................IAQTILQGFDAQYGRFLEVTuGAQQRFEQADWHAVQQAMKsRIHLYDHHVGLVVEQLRsI...Ts.u.p.s.sD............................ssFLhRVKcHYTcLLPDYPRFEIAESFFNSVYCRLFcHRsLoP-+LFIFSSQP.......ERRaRol.PRPLu+cFaPc.....cGhcshLhRlloDLPLRL.WpNpuRDIcYIlppLpEsLGsc........pLscs+lQVANELFYRNKAAWLVGKLls....ssu..s....LPFLLPI......Hps...-........cG...................cLFlDTCLTosAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKoTAELYhAIGCQKHuKTEsYREYLsaL.p.ts...............sEpF..ItAPGIRGMVMLVFTLPGFDRVFKlIKD+FAPQKEhot....A+V+ACYQLVKEHDRVGRMADTQEFENFVL-K++IuPALht.LhpEuspKIsDLG-......pIVIRHLYIERRMlPLNIaLEQs-sQ.................Q....LRDAIEE....YGNAI+QLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNF.RDIPPPRYPEDE............LASEPWYSVuPsDV..F.PEE.FRH.aLCuDPRltsLFEEMHADLFcA-YWRuLQsRI+-GHVEDVYAYRR+QR............................................	0	19	60	96
+6143	PF06316	Ail_Lom		Enterobacterial Ail/Lom protein	Moxon SJ	anon	Pfam-B_12325 (release 9.0)	Family	This family consists of several bacterial and phage Ail/Lom-like proteins. The Yersinia enterocolitica Ail protein is a known virulence factor. Proteins in this family are predicted to consist of eight transmembrane beta-sheets and four cell surface-exposed loops. It is thought that Ail directly promotes invasion and loop 2 contains an active site, perhaps a receptor-binding domain [1].  The phage protein Lom is expressed during lysogeny, and encode host-cell envelope proteins. Lom is found in the bacterial outer membrane, and is homologous to virulence proteins of two other enterobacterial genera. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis [2].	20.80	20.80	21.70	20.80	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.13	0.71	-4.80	2	1349	2012-10-03 17:14:37	2003-06-05 14:47:45	6	3	430	0	22	1298	2	177.20	65	97.07	CHANGED	MRKlCAsILSAslhLssuGsPA.AuEHQSTLSAGYLpspTDhPGSDDLNGINVKYRYEFTDTLGLITSFSYANAEsEQKTHYsDTRWHED.VRNRWFSVMAGPSVRVNEWFSAYAhAGVuYuRVSoFuGDYhplTssctKpp-hLTtSDsuRhSpTuLsauAGVQhNPTEslsVDlAYEuSGpGDWRT-uFIVGsGY+F	.....................................MRKlhAsILSA.s.lh.L.ss.u.G...s..P.A..h..A.u..E..c..Q..uTLSAGYL..psp........T...s...s.......P.......G.......S......D......s.........L....p....GINVKYRYE.F.T.D....s..LGhlTSFSY.A....ssc........s...c..Q..h.T....+.Y............S.....D........T..R.......W.......H.E....D.SVR.N...R......WFSVMAGPSVRVNEWFSAYAM..AGVAY..SRVSTFSGDYLRVTDNKGKTHDVLTGSDDu..R..HSNT..SLAWGA.GVQFNPT.ESVsIDlAYEGS.......G...S....G....D.....W.R.T...D....GFIVGVGYKF..................................................	1	2	6	10
+6144	PF06317	Arena_RNA_pol		Arenavirus RNA polymerase	Moxon SJ	anon	Pfam-B_12490 (release 9.0)	Family	This family consists of several Arenavirus RNA polymerase proteins (EC:2.7.7.48) [1].	32.40	32.40	32.60	39.20	31.70	32.30	hmmbuild  -o /dev/null HMM SEED	2207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-14.22	0.69	-15.07	0.69	-7.99	14	233	2009-01-15 18:05:59	2003-06-05 14:48:14	6	1	46	2	0	207	0	1086.60	42	99.88	CHANGED	M-EplsElKDLlpKals-c-cLucQKhsFLuQscs+hlLhEGLKLLShhlElDSCctsuCpHNocpKoV-sILp-pGllCPoLPhVlPDGaKLsGssLILLEsFVRssPpsFEpKacpDhsKLhsLKcDLppsGITLlPllDGRosY.schhPDWssERhRaLLhcLLchuppssch.hEEpEYpRLscSLSsspsps.GlEslpsLK-sphsa.-+Lhc.hatGlNsclstscl+tclhclaphFRpcl.cpGhhcspFh+o-+ppLlppLsp..hh....hstttpsslsph.hshs+hhsllt.Lhhp.lcptpptpp.ssp.ph......p.ahplLShhNKlKuLKVhNTRRpsLLhLDlIhLshhhclhctpstthpp.....hhlGpthhuVNDRLlsl.tsh+.lcKhlppp...................spahphsp+hLp+uppsL.hsslohhhhtsD..h-hhhplu.phh.c....th+PshpYppspppthssstpphc..........t-php.L+tLSSlSLuLVNSMKTSuos+lh.NEtshtRY.tsVRC+EsYhQcF.hhcuhthhLlYQKTGEpS+CYSl.hsc......hsEhsSFYuDPKRFFLPIFSp-VLhphs-pMlSWL-hss-....lpslcsLL+hLlLsILssPSKRsQpaLQGLRYFlMAaVs-hHHh-LhsKL+.-hlTsoEhllh+LhssLhphlLspuscs...hop+FKFlLNlSYLCHLITKETPDRLTDQIKCFEKFlEPKlcFsslhVNPspsu..TtEpE-thlcuhc+FhSKchpsps-...hKpPGVS+-llShhlShFNsGpLhhpu-LKp...DPhpsShouTALDLuSNKSVVlsKhs-.GphlhpYDapKLVSssVsplsEpFppKGKYpLs.c-h-atI.+sLosLV.spppspssp-chs...........-pLsE.....-tschFcpl+psVphsls+hcpspphp...st...tpppshss...Lcplhssc....thh+hI+uElShH.VcDFDsslLst-hYcElCsuVY.sssh+spYFhpcshc.CPLshLhKNLoT+sYp-pEaFpCFKhlLlQhshsphhG+YcHhp+ppLsFp.-sh+Lc--VRISpRESNSEAlu+tLshohhTsAuL+NLCFYS-ESPTpaTSlussoG+LKFuLSYKEQVGuNRELYlGDLpTKhhTRLlEDYhEAlspphchoCLNsEKEFE+AIhsMKhsVs.GpluhShDHSKWGPhMSPhLFLshLpsLchc..cstsclc.p-sV.slLpWHlHKlVEVPFNVlpAhhpualKRpLGLMspsupoloE-FFaphFp.pGhVPSHISSVLDMGQGILHNoSDhYGLIoEpFINYsLchlasshssuYTSSDDQIoLhcpshhch.-...p-s-EaLplLEFHpaLSspLNKFVSPKSVhGoFsAEFKSRFFVWG-EVPLLTKFVAAALHNlKCKpPpQLAETIDTIhDQsVANGVslclVstIpcRT.pLlcYSsYP.sPFLhhpcpDVKDWVDGoRGYRlQRpIEslhs-s..sphIRsssRKlas+lKpGclaEEahlshlupsss-uLpshhphhus-p.phc-.LpapWLNLsuatsLRhVLRpKlh.oushsL-cEclPTLlKTlQSKLSpNFTRGApKlLuEAINKSAFQSSlASGFIGhCKohGSKCVRssptt.lYIKclhsplpsppt..s.hss.thslhhCppsLcp.........lspa.RPlLWDYFslsLoNAhELGsWVhupsph.....sphshhhsNPs.aaslKPpss+.LED+lGhNHllaSlRR.YPplFE-HLhPFMSDLsss+hpWssRlKFLDLCVALDhssEsLullSHllKhKR-EhYIVhps-LuhuHsRpspslspEhslSspclCpNFhhQlhF-ShlpPhVhTTpsLtSFhWFschhpLP-.-uttcLG.hosFl.clhppslpRsMahcDLthGYsh.shchsphhls.ssplhs.sLsspcphpslp-hhthhus.cshslclslolcap+pSpchchcRphshphphps.hphssl............hplcslshhhSGulssHhlLDshpLlhspPhFpGcps..hslsshhhcs.lsts.sptshhpplclshssahh-L.scasacllGP-sp.sPLVlccGtlhcssc+lushpsplpspslhhhlssL..-cp-tltshLssLa.ahtsss.p..t..lchsppshthhh-tacphLscsLcshs-Wh-FtsaulCaSKShsslMIpsspGshRLKGhhCR.LhtsspshE	.............l..h+.hh.p.h.p..th..Q+..hLsQ.p...lhhEGhKLLS.hlEl-Ss.tpsC.hN..ph.lp.lL.c.tlhsPsLs.lhPDGaph.spsllLLEsFVRss..pFEpKa.tDh.KL.plptDl...sl.LlPllDGRssa.sp.hs-Ws..+hR.hlhplhp..p...t..hE-.EY.RLh.SLt.h.sp..Gh-sh..l.c.t..a..pl.t.hh.sl.sphp...hh.tl.p.h..ap..l..tt.....h...p...hlt.h.............................h..p..p...hh..l......................................h..hhS.hNKlKu.+lhNTRR..hh.hDhlhh...h..................hh.t.h..sNDRhlsh..h.p.h.phh.tp......................h...h..hh.p.................l.......p...t.......................P.h.Yp..t...................................hphLSplsLuhhNSMKTu.ss+hh.Np.t..pa.t.V.hpEsa.Q.h....t....LhYQKTGEpo+CYul...................SFYsDPKRaF.slhSt.Vl.thh..MhsWlt...........ht..hhhlhl.hls.PoKR.Qh.lQshRYhlMAhssph...pL.pKl....ho.s-..h..h...lh..lht..t.p....hsthFKahLNlSYhCHhlTKETPD.......................................................................................................................................................................................................................................................................................................................................................................................................................................EuluctLsho.hhsuhL+NLCFYSp-SPppasuhusssGpLKFuLSYKEQVGuNRELYlGDLpTKhhTRLlEDa.Euhs..hphoCLNs-pEFppAlhsMp.sVp.u.hshSh.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+6146	PF06319	DUF1052		Protein of unknown function (DUF1052)	Moxon SJ	anon	Pfam-B_12539 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function.	22.00	22.00	22.70	22.30	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.96	7	250	2012-10-11 20:44:44	2003-06-05 14:49:30	7	1	247	1	81	215	98	150.30	46	88.32	CHANGED	MsIlp.hs.sPLhDGRQSEpAhhVRRGsQRLLhphtausLPELsLASGRRADLluLotKGEIWIlEIKSSIEDFRVDRKWP-YRhHCDRLFFATHssVPt-IFPEECGLlLSDGYGAchlREAPEH+lAsATRKulhLpFuRsAAtRLhhAEhsshcs	..............................................+.stpAh....hltRGVpRLhh.s.hG.huslsElsLs..sG..R.RADllAlutK....GEI....WIVEIKSSlpDa.+uD...+..KWs-YRsaCDRhFF.As...cs...s.l...P...p......-......l...h......P-.-..sGLI..........lu..........D.....u....Y.....G.......A.........-..IlR-APEH+.LAuApRKulhL+FARsAAtRLhthp.....ss.............................................	1	22	51	61
+6147	PF06320	GCN5L1		GCN5-like protein 1 (GCN5L1)	Moxon SJ	anon	Pfam-B_12526 (release 9.0)	Family	This family consists of several eukaryotic GCN5-like protein 1 (GCN5L1) sequences. The function of this family is unknown [1,2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.65	0.71	-4.28	10	239	2009-09-11 00:23:16	2003-06-05 14:49:52	8	9	196	0	159	223	4	113.00	30	62.23	CHANGED	hlKEHpp+Qupp+phQE+h++EAIsuAssLTpuLVDslNsGVAQAYlNQK+L-sEAKpLpssuusFuKQTsQWLpllEsFNsuLKEIGDVENWuRsIEsDM+sIsssLEhsYcspp.sps....S	......................................................pt.p...-ct+p-Al.tus.s....s.lspsLs....c.p.L....sstVsp...ha...hNp++L-pEs+p.Lpt.pssphsKQ.osp.Wlp.hs-shspuLK......El.GDlpNWAc.lEhDhpslsp...sLchs.ctt......s.........................	0	44	78	122
+6148	PF06321	P_gingi_FimA		Major fimbrial subunit protein (FimA)	Moxon SJ	anon	Pfam-B_13339 (release 9.0)	Family	This family consists of several Porphyromonas gingivalis major fimbrial subunit protein (FimA) sequences. Fimbriae of Porphyromonas gingivalis, a periodontopathogen, play an important role in its adhesion to and invasion of host cells. The fimA genes encoding fimbrillin (FimA), a subunit protein of fimbriae, have been classified into five types, types I to V, based on nucleotide sequences. It has been found that type II FimA can bind to epithelial cells most efficiently through specific host receptors [1]. Human dental plaque is a multispecies microbial biofilm that is associated with two common oral diseases, dental caries and periodontal disease.  There is an inter-species contact-dependent communication system between P. gingivalis and S. cristatus that involces the Arc-A enzyme [2].	30.50	30.20	30.50	30.20	30.40	30.10	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-12.17	0.70	-5.20	32	270	2012-10-02 11:46:57	2003-06-05 14:50:11	6	5	62	6	21	280	1	299.40	14	54.52	CHANGED	hsuCop--sst.ssss..............Aplolsl.......tpstssssssssp....sEstIpsLslhlFs..tssth.h........scspsshpss.............h............tst....sG.stplhllAN...................................t.h.hsspshs...cht..shhtplsts.sts....tssLsMouthtss..shhsup..................ph..h.............................sssts..............p..t.ssslpLpRssA+lslsthp..........hphssp.pphtshhh..............hpplalhps...........+pp.s.h......................................................phaGs.shsp...........hssst.......................ahhu........phsshs...sthsss.s.........hsstshh......sssh	.............................hhuCsp-p.ps.s..sssst..........t.....splolsl..........tsstssp.sssssp.................sEs..p....IsslplhVFs.....tss..phh..h..................s.psspshtss...........hht...............pss.....sG.ppplhllAN..........................ts.h.ssspsls......chp.....shhsphssp...stp.............t.s...slhMouthtss.....shhssp...........................................................................................p..ttsss..lplpRssA+l..sl....hp...........................h.hs...t..ts..hhshh................................ppl.ahhth................ppp.t.h..............................................................................t.hss.th............................t..............................a..t...........................................................................................................................................................................................................................................................................	0	2	16	21
+6149	PF06322	Phage_NinH		Phage NinH protein	Moxon SJ	anon	Pfam-B_12973 (release 9.0)	Family	This family consists of several phage NinH proteins. The function of this family is unknown.	26.00	26.00	26.50	27.40	24.50	25.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.03	0.72	-4.35	4	231	2009-01-15 18:05:59	2003-06-05 14:50:30	6	2	200	0	2	53	0	62.60	66	96.08	CHANGED	MTaoVKTIPDMLlEsYGNQTEVARhLsCsRsTVRKYstDKEGKhHAIVNGVLMVHRGWsctpDt	..MTaTlKTIPDMLlEsYGNQTEVARhLsCsRsTVRKYhtDKEu+tHAIVNGVLMV.HpGhpt.hD.h.................	0	0	0	1
+6150	PF06323	Phage_antiter_Q		Phage antitermination protein Q	Moxon SJ	anon	Pfam-B_12730 (release 9.0)	Family	This family consists of several phage antitermination protein Q and related bacterial sequences. Phage 82 gene Q encodes a phage-specific positive regulator of late gene expression, thought, by analogy to the corresponding gene of phage lambda, to be a transcription antiterminator [1].  	25.00	25.00	29.00	28.90	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.52	0.70	-4.97	9	404	2009-01-15 18:05:59	2003-06-05 14:50:50	6	1	228	0	15	190	0	214.30	70	99.44	CHANGED	Mssp..LpalRpQLhsATADLSGuTKGQL.AahEpAph.DTspYpRK...+lRltDcsTGchITlsNPPlsGKQShAKGuuIsLVp.VEaSTuSWRRAVhSL-EcppAWLLWsYS-shsacaQVsIspWuWpcF...psphss++luuKThERL+pLlWLAAQsVK....sELtGc-h..YphpE.LAsLVGVopcNWScsast+WhsM+chFhpLDppALLsss+sRSpQKss..ppslAcls	..........................MNsQY.LQaVREQLhlATADLSGATKGQLEAWQEpA.F.DTGpY+RK.....K.RhhD...EVTG.....K....MIThDNPPIsGKQShAKGoSIsLVSPVEFSTSSWRRAVLSL-EHpKAWLLWCYStSlpWEaQlsITQWAWsEF...psp.usRKIAGKT.-RLKpLIWLAAQsVK....uE.LhGtEs..YEYQ-.LA.LlGVToKNWScTFTc+WVAMKHIFhpLDS-ALLhVhRTRSKQKAsF.pQslAKl.............	0	0	3	10
+6151	PF06324	Pigment_DH		Pigment-dispersing hormone (PDH)	Moxon SJ	anon	Pfam-B_12230 (release 9.0)	Family	This family consists of several eukaryotic pigment-dispersing hormone (PDH) proteins. The pigment-dispersing hormone (PDH) is produced in the eyestalks of Crustacea where it induces light-adapting movements of pigment in the compound eye and regulates the pigment dispersion in the chromatophores [1].	20.30	20.30	21.30	22.30	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.90	0.72	-6.13	0.72	-4.59	7	54	2009-01-15 18:05:59	2003-06-05 14:51:14	6	1	44	0	18	66	0	17.80	76	21.14	CHANGED	NSELINSLLGlPKlMN-A	NSELINSLLGLPKsMN-A..	0	3	5	15
+6152	PF06325	PrmA		Ribosomal protein L11 methyltransferase (PrmA)	Moxon SJ	anon	Pfam-B_12272 (release 9.0)	Family	This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.03	0.70	-5.29	31	4673	2012-10-10 17:06:42	2003-06-05 14:51:37	8	31	3837	31	1275	19899	6047	251.40	29	79.81	CHANGED	sWhElplpssp-stEs....lsshL....h-.h....G.uhuVsl.......p.Dup..........t.-psl..a..E.......sh....spt..l..pt............stlh.Ah.......astcs..-.htt.......lls.....t.....lp.t.....ht......hhh.....pts.......phpl.....ppls-pDWspsWpcha+Ph+huc+lhIsPoW.c-h...Pp....sstlslcLDPGhAFGTGTHPTTphCLphLEph.............lpsG..c....sV..l.DlGsGSGILuIAAh+LGApclhuhDlDshAVcuup-NhchN......plss..pltl...h...L.........t-...hs........p.........tph...DVlVANILAsslhpLssplhthlKssGhllhSGIlpcptctV.t.c.sh.p.p.uFpl.shhpcp-Wsslsup+p	...........................................................................................................................................................................................h......h......t.......s.....s.h...h........p.............................................................................t........................................l...u.h.......h.......t...t...............t................hh.t.........l.t..t.............................t..th.....................................t.h.p.h.......ptlt-.pDW.ptW.h.p...a.c......Ph..ph........s.....c..p...h.....h.I.h.PoW..pph.....t.............sth..l.lDP.Gh...A.F.G........TGp..Hs.T.T.t....hs..l..p...h....L.....-..p.h............................................h..s...u.....c.........sV...l...D..l..G..s..G.S..G..I......L..u....I...A........A.......t.........+.......L..............G.....A.........p........c..........l.....h.....u......h....D.....l......D....s............h.......A.......l.....p....s......u.........c.....-......N.....s.....c....h.....N............................s..l.ss.......pl...p.l.........h...........h...........................t...-.....h.................................p..............tph.D......l....l......l......A......N........I.......L........A........s.................l......h.............h.........h......................h..........t....h...h.......t.........s....G.h...h.h..h.......S...G......l...l...t...p...p........h...p.......l..h..p..th....t.t...th....t.l.........h....h..t.p...tt.Wstlhh..............................................................................................................	0	424	747	1006
+6153	PF06326	Vesiculo_matrix		Vesiculovirus matrix protein	Moxon SJ	anon	Pfam-B_13088 (release 9.0)	Family	This family consists of several Vesiculovirus matrix proteins. The matrix (M) protein of vesicular stomatitis virus (VSV) expressed in the absence of other viral components causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein [1].	20.80	20.80	21.40	39.40	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.41	0.70	-4.90	11	133	2009-01-15 18:05:59	2003-06-05 14:51:58	7	1	41	2	0	94	0	202.50	45	96.55	CHANGED	M.ppLpKhht.tt.t..s+pppsp......h...tPPuYp-.............PoAPl....hGh..-th-ph-..thph.phhhcsplplpoppPhcohp-shpslstW.cpYsG.hsp+PFa+hlhlhsuppL+tss...sssspscYsuphpGpshlhHplu.hPPhhph.csaspsaphtttptslslshplphssopcpssslhchh.....shpcpschpphhphaGL.hpppssspalh	.................................................................................ap....htEPTAPo............LGIIQsKCKRAD........WLIKSHLTITTNYEIKEWuTWDRAISDILDLYDGNPVFKPILLFVYYVLAYNARKIP....GPoNGVRYGAYFDELTTV..WHAI...PELMNQEsDYSYNHRVlHRKIQYVISFKIQMSSTKRRTSPIESFIE..VTsEGLKHTPQFTTILDRARFVYSLTGGRYVIH..................	1	0	0	0
+6154	PF06327	DUF1053		Domain of Unknown Function (DUF1053)	Yeats C	anon	ADDA_1330	Family	This domain is found in Adenylate cyclases.	21.10	21.10	21.10	21.10	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.41	0.72	-3.67	12	508	2009-01-15 18:05:59	2003-06-05 15:02:07	9	11	76	0	281	378	0	96.70	28	8.88	CHANGED	schhpsWss-+PFtplpptsp.stt.t.............................................ulshtpsph........ppstppsts.--El...D-hltpsI-thSspch...+p-clppahLhFp-suhE+cYspht-shF	................................................................pWs.st.pPF.ph.tt.pp.hs..pt.p.h..................................................................sls.tppp.............cstppp.tps--.El...s-hlhpuI....DupSsc+h...........+u-clpp..hsLhFpc.psLE+c...Yppts.shF..................................................	0	40	60	162
+6155	PF06328	Lep_receptor_Ig		Ig-like C2-type domain	Yeats C	anon	ADDA_13736	Domain	This domain is a ligand-binding immunoglobulin-like domain [1]. The two cysteine residues form a disulphide bridge.	20.30	20.30	20.30	21.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.97	0.72	-4.11	12	304	2012-10-03 02:52:13	2003-06-05 15:36:22	6	14	53	4	105	260	0	86.50	28	10.89	CHANGED	hsc.sshhhsss.llplGSshohsCllK..ppChp..psssphIlW+hp...h.Pppphphlscps..SplThsshtshps.......sLhsChlspuspcph	...........h....h..hhPsp.ll.plGSslohpCllK..ppst......ssup...pIl.Wphsht.tlPpppYphlscps..SpVThss.hsttps.......slhs..Ch.t.tp..p......................	0	6	14	37
+6157	PF06330	TRI5		Trichodiene synthase (TRI5)	Moxon SJ	anon	Pfam-B_13220 (release 9.0)	Family	This family consists of several fungal trichodiene synthase proteins (EC:4.2.3.6). TRI5 encodes the enzyme trichodiene synthase, which has been shown to catalyse the first step in the trichothecene pathways of Fusarium and Trichothecium species [1,2]. 	23.80	23.80	24.40	24.60	22.30	23.70	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.26	0.70	-5.81	3	159	2009-09-10 20:52:56	2003-06-05 17:43:25	6	2	67	40	56	165	0	252.40	45	91.90	CHANGED	M-sFPTEYFLsTuVRLLEsI+YRDSNYTREERIENL+YAaNKAApHFAQPRQQpILK.VsPKRLpASLRTIVGMVVYSWuKVSKEsMADLSIHYTYTLVLDDS.SDDPHssMLoFFDDLQAGREQKHPWWsLVNEHFPNVLRHFGPFCSLNLIRSThDFFEGCWIEQYNFpGFPGSDDYPuFLRRMNGLGHCVGGSLWPKELFDEQKpFLEIToAVAQMENWMVWVNDLMSFYKEFDD.RDQsSLVKNaVTCDEITLDQALEKLTsDTLHSScQMl-VFuDKDPclM-TIECFMHGYlTWHLCDaRYRL+EIYE+sccQETcDAtKFRKFF-QAAcVGAV-sEEWAaPsVAaclEVRAspcu-VK-uQ.pAlLoSlEss	....................................................................................................................................................................as+lo+.EhhsslSIahTYsllLDDS...p-DP..h..ssMhsYa.sDLpuGc.pQ.t.H.P.WW.tLVNEHFP.NVLRHFGPFCSLNLIRSTlDFFpGC........W....I..E.........Q...a....N...F..tG..a...P...G.......Sp...D..YPpFLRRhsGLGcshusslWPKc.FsEp...ph....FlE......h.s......sAls.phpsahsalNDlhSFYKE...s.tp-phshl.pshshspthoh.puLc.cl.sp-slpu...s.c.phhtl..h...s.ptss.phhtshptahpGahhhHh..t.RY+h.-h..........................................................................................................	0	17	28	48
+6158	PF06331	Tbf5	REX1; 	Transcription factor TFIIH complex subunit Tfb5	Studholme DJ, Wood V	anon	SWISS-PROT	Family	This family is a component of the general transcription and DNA repair factor IIH.  TFB5 has been shown to be required for efficient recruitment of TFIIH to a promoter [3].	20.30	20.30	20.80	30.30	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.13	0.72	-4.20	30	254	2009-01-15 18:05:59	2003-06-05 18:43:11	7	1	225	6	186	224	3	67.20	35	85.84	CHANGED	MspAh+G.lLlcCDPulKplllplDs.pphs....aIlE-LD.-THLllp...sshlphlKpclschhspspass.p	..............MspshK..G.VLlpC.DPuhKphlLplDpppshs..........FIlc..DL..D.-sHlhlp...sphlphLcp+lschh-pssa....t..............	0	57	94	151
+6160	PF06333	Med13_C	TRAP240; TRAP_240kDa; Med13; 	Mediator complex subunit 13 C-terminal	Studholme DJ, Wood V	anon	[1]	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood [4].	19.10	19.10	19.80	19.10	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.60	0.70	-5.94	23	356	2009-01-15 18:05:59	2003-06-06 10:13:06	7	8	224	0	227	344	0	402.80	26	25.44	CHANGED	Vlallsshspss..........uhlshsttFhsL.....pthpspsph.ts-lhLpIlPhchlhss....pphhl.s.schtsLuhslYspC....Ps.tt.tph......sss.hshlscshPcpIsF+lhss..........................pssshpcsshLHlAYs+ShDpcWlsAAWSDspGphppTpoasls.pspshpp........shpplps-IWphohsL...........hspstu+hplllsRlss.lsc-ELtpWppLssp.t.......................spplsLsllsVssssclh...........................................sss.s...s......htspspooPssssts...........shhossphtsusss.tss...................................s.................tss.t.ts-thlh....Dhsp-saullhspsLspssslpch..AltSGYLl+ps...................sss..cshhphcVNllpss..........psshcp..............lL+plLppYRsLusLspshGlpctpt..........................uhlPWHlsslt+	...............................................................................llahl.s.s..s.................t..p..shhhhtLhpta.phh.p.t.h.....t..tsph.lQllPhp.hlhp.....pp.hh...pphtplAhpsaspC....................s.t.t...pshh............hsh.hhh....hs...ph.Pp.l.......plhss........................................sps.p.c...ssLaluYs....h..S.hDp.RWlhAuhTD.hGchhcTthhs.lshs.sp............ttpp.....................shp...shpclWc.hshsl............hphs..sh.WRlVIsRl.........G.....t.lscsElc..sWshLlspts...........................................................................................ss.loh...slls.h-spsshhh...........................................................................................p.ss.s...hst...............ssthsTPtss.s.ps..............hshsoss.h.tsssss..s.............................................................................................................................................s.ts.......hs..s..s....t....h..........t..tp....ps...t..hh...p...ct...pp.............t..lhp.....sLu.GYhlpps...........................................................................................ssh..cs.h..thp..ls....hpss.................t.h.p..................................lL+.lLptYpsLuhLshs...s.ht.ctp............................ss.lPhHh.sh....................................................................................................................................................................................................................................................	2	55	103	176
+6161	PF06334	Orthopox_A47		Orthopoxvirus A47 protein	Moxon SJ	anon	Pfam-B_13263 (release 9.0)	Family	This family consists of several Orthopoxvirus A47 proteins. The function of this family is unknown.	25.00	25.00	81.80	81.70	19.90	24.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.80	0.70	-5.27	2	47	2009-01-15 18:05:59	2003-06-06 10:35:14	6	1	18	0	0	40	1	220.20	90	98.68	CHANGED	MGNKNIKPSKENRLSIL.KD+MDSFKRGS.....FREKS+ATIQRFSSLRREHlKVDHPDKFLELKRtIYtIIQKSSSIDVDKRTKLMSNIKTMMINPFMIEGLMTSLEsLDPDNKMSYSSVMILGEFDIINISDNcAAFEFINSLLKSLLL.........EYSISNDLLYsHINALEYIIKNTFNVPERQLILRsQYLTPIFSDLLKYAGLTIKSNILMWNKpFIKPVSDLYTShpLLHCVT.	..........................................MGNKNIKPSKENRLSIL.KD+MDSFKRGSWATSSFREKS+ATIQRFSSLRR...EHlKVDHPDKFLELKREIYtIIQKSSSIDVDKRTKLMSNIKTMMINPFMIEGLMTSLEsLDPDNKMSYSSVMILG.EFDIINISDNEAAFEFINSLLKSLLLLNTpQLKLLEYSISNDLLYsHINALEYIIKNTFNVPERQLILRGQYLTPIFSDLLKYAGLTI.KSNILMWNKpFIKPVSDLYTShRLLHCVTV....	0	0	0	0
+6162	PF06335	DUF1054		Protein of unknown function (DUF1054)	Moxon SJ	anon	Pfam-B_13269 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.10	21.10	21.40	22.20	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.27	0.71	-4.64	22	540	2009-01-15 18:05:59	2003-06-06 10:37:23	7	2	532	2	56	275	3	191.60	48	95.26	CHANGED	FopcDFcsFplcGL-sRMpslpppIcPKhptlGpphushLos.sG.cEhasHlAKHARRoVNPPsDTWlAFussKRGYKhhPHFQlGLW-s+lFlWhAlIaEs...pKtphupthhcphshlpp.lPscahlShDHscscsh.hsphs...LpphhcRhpsVKKuEhLlG+pls+c-slh.hss-chhphlcpsacpLLPlY	.....FpsKDFcsFsV-GLDtRMpAlpp.I+PpLcpLGEhFusahospT.G.-sFasHVAKHARRoVNPPcDTWVAFussKRGYKMLPHFQIGlaccplFlhFulhaEsc..sKsphA+s.F.cch.pt.lpp....LPcDahl...SlDHhKPsthhl+.-hspcpLpcslpRhtsVKKuEFhlu+tIsPp-tph.posctFlAhlEpTacphLPhY...........................................................................	0	21	35	48
+6163	PF06336	Corona_5a		Coronavirus 5a protein	Moxon SJ	anon	Pfam-B_13277 (release 9.0)	Family	This family consists of several Coronavirus 5a proteins. The function of this family is unknown [1].	25.00	25.00	28.10	28.10	21.60	20.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.14	0.72	-4.10	3	85	2009-01-15 18:05:59	2003-06-06 10:42:25	6	1	12	0	0	84	0	63.90	84	99.93	CHANGED	MKWLTSFGRAVISCYKuLLLTQLRVLDRLILDHGP+RoLTCARRVLLVQLDLVYRLAYTPTQSLV	.MKWLTSFGRAhISCYKuLLLTQLRVLDRLIL-HGP+RsLTCuRRVLLhQLDLVYRLAYTPTQSLV.	0	0	0	0
+6164	PF06337	DUSP	DUF1055;	DUSP domain	Yeats C, Bateman A	anon	ADDA_8548	Domain	The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved [1]. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet [1].	29.10	29.10	29.20	29.10	28.60	29.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.54	0.72	-3.60	139	806	2009-09-10 16:33:45	2003-06-06 10:51:54	7	46	214	12	544	743	3	98.80	29	10.54	CHANGED	spthYllst.p.........Whppappalpts...ptt.....................................................................................................................s...........sI...s.....Nsslhpspt............................plc....pltpstD.ahll.........sp.psWphlhph.Y.u...uustlhppsht	..............................................................................................t.hYllst...p.........Wacp.Wcpa.V...thp..s.s.................................................................................................................................................................PG...........PI...D.....NosLhpsp.s.s...............................pL+.t....pLhpstD.Yhll............PpcsWphLhsh.Y.G.....Gs.slsR.h..p....................................	0	219	288	414
+6165	PF06338	ComK		ComK protein	Moxon SJ	anon	Pfam-B_13324 (release 9.0)	Family	This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level [1].	19.10	19.10	19.10	19.30	18.70	18.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.78	0.71	-4.82	19	719	2009-09-11 05:13:32	2003-06-06 10:58:32	6	2	443	0	58	336	0	150.30	29	87.47	CHANGED	M......ppph..c...........YhIsptTMslhPhhpstpph..ocllEh-ssahs..h+PhcIIc+SC.+aaGSSYtGRKcuTpclhGlopKsPIhlsPppslYaFPTpSsppt-ChWluapaIcphcphctpcs.hlhFtNGpolpLslShpShcsQhtRouhL+hchpcchctptp	.......................................................................p.h.lptts.MhlhPhh..st.th..ocllchcpshh...hps.clIc+SC.+haGsoa...G.++ttopclhs...I..spK.sPIhl..sPh......h.hhFPTc...S...p.....p.sps...lWlshpa.Icshc...t...l..cs..ppp....hlpF.N.s..po.lplcl..ShpslppQhpcohhlhh.hp.p.p...st.......................................	0	15	32	49
+6166	PF06339	Ectoine_synth		Ectoine synthase	Moxon SJ	anon	Pfam-B_14542 (release 9.0)	Family	This family consists of several bacterial ectoine synthase proteins. The ectABC genes encode the diaminobutyric acid acetyltransferase (EctA), the diaminobutyric acid aminotransferase (EctB), and the ectoine synthase (EctC). Together these proteins constitute the ectoine biosynthetic pathway [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.50	0.71	-4.21	60	443	2012-10-10 13:59:34	2003-06-06 11:03:08	7	3	411	0	130	434	87	124.80	50	95.48	CHANGED	MIVRsL.p-ltsT-Rc..Vpup..sWpSpRlLLccDsMGFSFH.ThIhAGoEpchaYpNHlEuVYClpGcGclEslssGcsatIcPGshYsLscHD+HhLRApp..-h+hsCVFNPPlTGpEVHDEsGsYsh.s	..............................MIVRsl.c-hppT..-Rc..Vsup.......sWcSpRhlLtcD.sh..GFSFH.TsIaAGT-oc....lH.Y.pN.H.l...E.uVYClpGEGElE..s...l..........t.....s....G....c..sasIp.P.GolYlLDpHDcHhLR..utp..-hphsCVF..NPPlTGpElH.DpsGsYsl.t..............	0	41	87	113
+6167	PF06340	TcpF		Vibrio cholerae toxin co-regulated pilus biosynthesis protein F	Moxon SJ	anon	Pfam-B_13058 (release 9.0)	Family	This family consists of several Vibrio cholerae toxin co-regulated pilus biosynthesis protein F (TcpF) sequences. TcpF is known to be a secreted virulence protein but its exact function is unknown [1].	25.00	25.00	432.60	432.40	18.40	18.20	hmmbuild  --amino -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.97	0.70	-5.31	5	44	2009-01-15 18:05:59	2003-06-06 11:25:21	6	1	39	2	1	18	0	316.70	87	93.87	CHANGED	FNDNYSSTSTVYATSsEA.......TDSRGSE..HLRYPYLECIKLGMSRDaL-N.CVTVSFPTsS-hFYGAYPucEE...GKpRTKEDFQARLLSGDYsuLEKLYlDaYLAQTTYDWcIPTRDQIEoLVNLAK-GKLoosLNsEYlcGRFLTKsD.GcYsIVsVGsV.ADsoPVKLPAlVSKRGLMGToslVNAlPsEIaPNIK.....lYpsTlSpLcPGssFcAshEYDssELpKHGYSs....lsDVpucVLVGVPuuc.GVIYsPVYpEos+sYahSsNhPGKclYslSTNDlHNGapWSssMFSNuKY+TQlVLTKuDGSGV+LYSKAYSEpF	FNDNYSSTSTVYATSNEA.......TDSRGSE..HLRYPYLECIKIGMSRDYLEN.CVKVSFPTSQDMFYDAYPSTESD.GAKTRTKEDFSARLLAGDYDSLQKLYIDFYLAQTTFDWEIPTRDQIETLVNYANEGKLSTALNQEYITGRFLTKEN.GRYDIVNVGGV.PDNTPVKLPAIVSKRGLMGTTSVVNAIPNEIYPHIK.....VYEGTLSRLKPGGAMIAVLEYDVSELSKHGYTN....LWDVQFKVLVGVPHAETGVIYDPVYEETVKPYQPSGNLTGKKLYNVSTNDMHNGYKWSNTMFSNSNYKTQILLTKGDGSGVKLYSKAYSENF	0	1	1	1
+6168	PF06341	DUF1056		Protein of unknown function (DUF1056)	Moxon SJ	anon	Pfam-B_13260 (release 9.0)	Family	This family consists of several putative head-tail joining bacteriophage proteins.	21.80	21.80	23.20	23.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.07	0.72	-3.94	6	36	2009-09-11 05:07:47	2003-06-06 11:28:42	6	1	35	0	6	37	0	63.10	37	99.65	CHANGED	M.......IFKphFshIWclFDVLhFILAhIslslTsFhhshshGsIololshhLhGhlSElloc..pKGGD	............M.IhKphFphIWp.hFD.lLhFILuhIslslssFhhshshGslululshlLsGhlSEhlsp...Kt.........	1	2	3	5
+6169	PF06342	DUF1057		Alpha/beta hydrolase of unknown function (DUF1057)	Moxon SJ, Bateman A	anon	Pfam-B_13294 (release 9.0)	Family	This family consists of several Caenorhabditis elegans specific proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.87	0.70	-5.60	6	46	2012-10-03 11:45:05	2003-06-06 11:38:02	7	2	10	0	44	763	581	261.50	31	89.71	CHANGED	EPKhhpKLVKFpscpt+hV-lpAVYEDohsSGSshGTVVuFHGSPGSHNDFKYlRsph-chsIRFIGlNYPGFc.TsuY.sQpasNhERpsYocALL-cL-lc..GKlIhhGHSRGCENALQTAssh......ssHGlVMlNPsGhRhHKGIpPh.RhpolsalaphLPp..hlusuh......hathhculGhKVpcGEEAsuAhRuhhshuLEcQlt.I-KLpcps.sKphIsFGGKDaLlEEEIVhEsLc+apGLsHFsh.ccpIoEc-htKIhcSFsssQpGsSVFlAcDsHFQNKopA-LlAEss+uhFD	....................................................................................................hph......tp.hplp.As.YpDs..hs...s..G..os..h....G...T...V.l.u.h.HG.o.P...G.S..H.p.D.F.K.Y..lp...s..h..L....-.p..h...s..lR.hIs...lNaPGF....t......o.s...............s.h....p................p..p...a.....s..N....ER...p..s.a.s.....p...u...l....lp.pL.s..lp.....s+.l..lhlGHSRGsE.NA...Lph..u..sth...................s..h..G...hs....hl.N...s...sG....h+...H..+..u...Ip.P..h.....+.h..t.h.......ls.h...lhp...h..l.p....hhhsth......................hht.hh.chl..Gh..+...l..p...s..G...c.....A......hsuh+s..h.ph..shcpp.h....l..cchpcps..h...........+hhlsauupDaLlEccI..Ehht..ta..p.shpHa..h.ppp..s-...c.p...h....c...Ihpsa.st.s.pptsol.htp-sHa.pKppAchlucsstthh..........................................................................................................................................................................	0	21	26	44
+6171	PF06344	Parecho_VpG	VPG_P3B; 	Parechovirus Genome-linked protein	Yeats C	anon	ADDA_6741	Domain	This family is of the Parechovirus genome-linked protein Vpg type P3B.	25.00	25.00	37.30	36.00	17.80	16.50	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.28	0.72	-6.56	0.72	-3.98	4	49	2009-01-15 18:05:59	2003-06-06 12:02:01	6	2	11	0	0	50	0	20.00	88	0.92	CHANGED	RAYNPTLPVAKPKGTFPVSQ	RAYNPTLPVsKPKGTFPVoQ	0	0	0	0
+6172	PF06345	Drf_DAD		DRF Autoregulatory Domain	Yeats C	anon	ADDA_2536	Motif	This motif is found in Diaphanous-related formins. It binds the N-terminal GTPase-binding domain; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of DAD to mammalian cells induces actin filament formation, stabilises microtubules,  and activates serum-response mediated transcription ([1]).	22.10	22.10	23.30	22.70	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.16	0.73	-6.14	0.73	-3.85	3	216	2009-01-15 18:05:59	2003-06-06 13:25:51	6	12	65	11	89	181	0	15.00	91	1.47	CHANGED	GVMDSLLEALQSGAA	GVMDSLLEALQSGAA	0	13	19	50
+6173	PF06346	Drf_FH1		Formin Homology Region 1	Yeats C	anon	ADDA_2536	Family	This region is found in some of the Diaphanous related formins (Drfs) ([1]). It consists of low complexity repeats of around 12 residues.	40.00	40.00	40.50	40.40	39.90	38.60	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-12.57	0.71	-12.86	0.71	-4.72	4	113	2009-01-15 18:05:59	2003-06-06 13:37:54	7	15	26	0	46	81	1	139.50	65	14.81	CHANGED	PPPPPLP..uGssIPPsP...................PLPsGssIPPPPPLPGGssIPPPPPLPGsAu.IPPPPPLP.GssuIPPPPPLP.GusuIPPPPPLP.GussI.PPPPPLPGGuGI.PPPPPLPGtsul.PPPPPLPsGsGl.PPPPPhPG..AsGIPPPP..PGhGhPPPPP.FGhGVPssPsLP	............................................PP.sPPL.s..GssIP.sP...PPLP...GsuI.PP.PPP....LPG.su.IPP.PPPLP.Gs..uIPPPPPLP.G..s.uIPP.PPPLP.G.s.uI.PP.PPPLPGus..GI...P...P.P....PPLPGts.Gl..PPP....PPLPsGsGl...P.P.P..PPhPG..usG.IPPPP...PshGhPPP.P....t..........................................	0	6	6	10
+6174	PF06347	SH3_4		Bacterial SH3 domain	Moxon SJ, Bateman A	anon	Pfam-B_13248 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function. These are composed of SH3-like domains.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.55	0.72	-4.42	29	1011	2012-10-02 18:48:24	2003-06-06 13:57:49	8	42	560	0	333	3517	2117	55.40	27	37.89	CHANGED	cssplslRpuPsssupVs.shlcsGlssplt.pspspWp+lp.ssGtpGWltpstLhG	.............................sstlslRsuPu.tsutlh..sh....l..c.t.G.h..s.l.p.l......t....p.....p.....p.....s.......s.....W....pcl.....c...s.....s....G.....h......p.....GWltpshL.G..................	1	110	232	271
+6175	PF06348	DUF1059		Protein of unknown function (DUF1059)	Moxon SJ	anon	Pfam-B_13303 (release 9.0)	Family	This family consists of several short hypothetical archaeal proteins of unknown function.	20.50	20.50	20.80	20.50	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.71	0.72	-4.15	17	231	2009-01-15 18:05:59	2003-06-06 14:01:29	6	2	177	0	99	216	25	56.20	26	83.59	CHANGED	hK.pFpCuslGhsCuachp.AsoE-EllctlttHA+hsHGhsclPp-hlscl+psI+cs	..................h.Ctt..h..s..hs..Cshtlp.Aco-sEllctsspHAtssH.s..hs..s.s.-hhppl+t.h.......................	0	21	46	78
+6177	PF06350	HSL_N	HSL; 	Hormone-sensitive lipase (HSL) N-terminus	Moxon SJ	anon	Pfam-B_13329 (release 9.0)	Family	This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin [1].	25.00	25.00	25.10	29.80	17.70	24.40	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.84	0.70	-5.34	6	166	2009-01-15 18:05:59	2003-06-06 14:21:03	7	6	104	0	86	151	0	251.30	43	37.71	CHANGED	hDpptlFsoLhslCc-NhuaFu.....uspsEsupRLpGsasulp-HhcsscPLVppltohhHcaDFDppTPGNGYRShlaVVcsCltHhl+huRYlsuNRsoIFFRpua.ltElEAYsphLspLpshLhasQpLhphs.ssGcLF.tsEu+ssEchlpchsTlpphCFYGRCLGFQFssSIRPhLphluIGMsuFuEsYhppp..usIuhAsSShaTSGKYhlDPELRupch.pIoQNhcVcFhKuFW.lsEoElhpoLsShsuopVKVNRllolPPEslpLPhspsscho................VsIssPpAHhGsG.PVpsRLIStshRcG..u	.................................................................hhtsL..htlsp-NhsaFs...........ts.schupRl.sshhtl.p-phhtlcshltplh.thsp...haDh....D.pT..PuNGYRSll.psspsClhHhlp.hs.+hlts.sRpolFFR..t.sa.htElEAY.hthLsp.Lp.........shh....hs..ppLh.ths....psGt...L..F....s-p..........thstphlpchsolcpsCFYGRCLGF..Q.Fssul+shLphluluhsoauEp..Ytppp....suluhsspSlhooG+ahlsPELRutch.cIhQshclcFhKuFWslsE....plh..........pplsshsusslpVschlplPsp.shphPhts....s.phs.......................VsIssP..AHhGsu.PV.hRLlShchRpG..u.............................................	0	32	39	65
+6178	PF06351	Allene_ox_cyc		Allene oxide cyclase	Moxon SJ	anon	Pfam-B_13374 (release 9.0)	Family	This family consists of several plant specific allene oxide cyclase proteins (EC:5.3.99.6). The allene oxide cyclase (AOC)-catalysed step in jasmonate (JA) biosynthesis is important in the wound response of tomato [1].  	21.60	21.60	22.20	22.20	18.90	21.00	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.04	0.71	-4.82	10	96	2009-09-12 22:21:42	2003-06-06 14:28:10	6	2	48	19	35	100	1	168.90	62	71.60	CHANGED	-su+PuKVQELpVYEINERDRGSPAYLRLSpKsV.......NSLGDLVPFSNKLYoGsLcKRlGITAGIClLIQHpsEKKGDRYEAIYSFYFGDYGHISVQGsYLTY.EDTYLAVTGGSGIFEGsYGQVKLpQlVFPFKLFYTFYLKGIp.DLPpELLussVsPSPoVEPoPAAKACEPHAVlsNF	..............................................................................p.upPsKVQELpVYEINERDRsSPAYL+.L.Sp.Kps...........NuLGDLVPFoNK............LYoGsL...pKRlGITAGlClLIQHhPEK...........pG...........DRYE.AIYSFYFGDYGHISVQGsYLTY..EDo..YL..AVTGGSGIFEGsYGQVKLpQlVFPFKLFYTFYLKGIs.DLPtELlspsV.PSPsVEPsPtAKAsEPpAslsNF...................	0	10	25	30
+6180	PF06353	DUF1062		Protein of unknown function (DUF1062)	Moxon SJ	anon	Pfam-B_13377 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.80	21.80	22.00	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-3.97	15	241	2009-01-15 18:05:59	2003-06-09 11:21:01	7	1	234	0	34	162	2	140.90	45	72.15	CHANGED	lNAp+KhLDlWLIYKCspCDpTWNhslFpRhslccIsPtLL-uLpsNDtshlctaAashtsL+RNstcls.t.s-acltcchhsssssphs...lclplphshPhsl+LspLLtppLtLSRoclcpLh-pGhIpssstt...sctL+pc	.....................VNuQKKlLDVW.IYKCo+CDhTWNloLFSRlsVucIs+-LasRLhuNDsuslphaAaDsulLKRNsAELu.upPD..F+Ip-R.hll.ul.s.uapp......lsVsVRlupsFpVpLLSlLK+QLhLSsAElKRhlEsGpIoGlohK..hu+KL+..s.......................	1	14	20	25
+6182	PF06355	Aegerolysin		Aegerolysin	Moxon SJ, Bateman A, Macek P	anon	Pfam-B_13415 (release 9.0)	Family	This family consists of several bacterial and eukaryotic Aegerolysin-like proteins. It has been found that aegerolysin and ostreolysin are expressed during formation of primordia and fruiting bodies. It has been suggested that these haemolysins play an important role in initial phase of fungal fruiting. The bacterial members of this family are expressed during sporulation [1].  Ostreolysin was found cytolytic to various erythrocytes and tumour cells [2]. It forms transmembrane pores 4 nm in diameter. The activity is inhibited by total membrane lipids, and modulated by lysophosphatides. The potential use of aegerolysins is reviewed [8] with special emphasis on their properties which would allow thier use in therapeutics.	20.60	20.60	21.10	21.80	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.63	0.71	-4.28	18	123	2009-01-15 18:05:59	2003-06-09 11:40:34	8	1	67	0	67	114	0	120.00	26	84.40	CHANGED	uQWVplcIhsphsptslpI+NspLshG+aacsss+cpploss-lsthhIts.ssptplsusGRpss.oGTEGshDlh...Du..-p+IsplaWDsPauu.+sNpaphpcpsscYtlEhushs.psuGslGsVslcl....s+p	.......................................phlt..hplhs.phs.tt.sltlcNspLph.....GKaa...p.ss.......cspclossplsthshts.ssph...plsusGRpsssoGTpGshDlh........ss..s..p+l..spl..hWDs.Pasu..sNpaph...ps...ts.....sp...Ytlthsuhs..p.sshGplslpl...t........................	0	11	37	56
+6183	PF06356	DUF1064		Protein of unknown function (DUF1064)	Moxon SJ	anon	Pfam-B_13437 (release 9.0)	Family	This family consists of several phage and bacterial proteins of unknown function.	24.60	24.60	25.00	24.80	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.66	0.71	-4.10	5	417	2012-10-11 20:44:44	2003-06-09 11:42:11	6	1	361	0	39	303	62	112.80	39	85.21	CHANGED	+SKYNAKKVEaDGIVFDSKsEspYYQpLcsshsusph-+l-lQPKFELhsK.FRKsGpl.RsIcYlADFslRp-u.cllEVIDVKGMlT...c-a+IKAKLFch+Yhp......hKs.KhpGpsahps	..................................hsKYsuKK.lp.h.cGIsFDSKsEscYYph.Lcp....p..pss....p.h..s...cl-lQP+FEL.s............p....h...p...........p.p....................R...sIpYlADFslap.ps...t............hl....c.VlDVKG...hhT.....cshplKtKlFchp....Y.p......h.h.h..p........................................	0	13	26	29
+6184	PF06357	Omega-toxin	Omega-atracotox;	Omega-atracotoxin	Moxon SJ	anon	Pfam-B_14633 (release 9.0)	Family	This family consists of several Hadronyche versuta (Blue mountains funnel-web spider) specific omega-atracotoxin proteins. Omega-Atracotoxin-Hv1a is an insect-specific neurotoxin whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels [1]. 	21.70	21.70	23.10	22.20	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.12	0.72	-4.37	2	17	2012-10-01 22:06:18	2003-06-09 11:58:20	6	1	5	2	0	20	0	37.10	79	71.75	CHANGED	SssCIPSGQPCPYsc.CCStSCTaKpNENGNoVpRCD	..SsTCIPSGQPC.PYNENCCSpSCTaKp.NENGNTVKRCD.	0	0	0	0
+6185	PF06358	DUF1065		Protein of unknown function (DUF1065)	Moxon SJ	anon	Pfam-B_14830 (release 9.0)	Family	This family consists of several Benyvirus proteins of unknown function.	25.00	25.00	50.00	49.90	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.58	0.72	-4.33	2	32	2009-01-15 18:05:59	2003-06-09 12:33:53	6	1	5	0	0	18	0	99.80	96	94.41	CHANGED	MVLVVKVDhSsIVLYIVAGsVVVShLYSPFFSN-VKAuuYAGAlF.suGCIMDRNSFAQFGuCDIPKaVA-SIo+VAhKEhDADIhschssVss+hVsLhEslh.lh.RlF	MVLVVKVDLSNIVLYIVAGCVVVSMLYSPFFSNDVKASSYAGAVFKGSGCIMDRNSFAQFGSCDIPKHVAESITKVATKEHDADIMVKRG-VTVRVVTLTETIFIILSRLF	0	0	0	0
+6187	PF06360	E_raikovi_mat		Euplotes raikovi mating pheromone	Moxon SJ	anon	Pfam-B_14708 (release 9.0)	Family	This family consists of several Euplotes raikovi mating pheromone proteins. Diffusible polypeptide pheromones, which distinguish otherwise morphologically identical vegetative cell types from one another, are produced by some species of ciliates. In the marine sand-dwelling protozoan ciliate Euplotes raikovi, pheromone molecules promote the vegetative reproduction (mitogenic proliferation or growth) of the same cells from which they originate. As, understandably, such autocrine pheromone activity is primary to that of targeting and inducing a foreign cell to mate (paracrine functions), this finding provides an example of how the original function of a molecule can be obscured during evolution by the acquisition of a new one [1].	25.00	25.00	51.10	50.70	17.60	17.20	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.55	0.72	-3.74	6	6	2009-01-15 18:05:59	2003-06-09 13:02:30	6	1	1	6	0	12	0	35.30	37	62.72	CHANGED	DhC-pAsAQCshThCp.hCt...sp.hC.lsVhss..Cs	DhC-pAsAQCshThCp.hCt...sp.hC.lsVhss..Cs	0	0	0	0
+6188	PF06361	RTBV_P12		Rice tungro bacilliform virus P12 protein	Moxon SJ	anon	Pfam-B_14960 (release 9.0)	Family	This family consists of several Rice tungro bacilliform virus P12 proteins. The function of this family is unknown [1].	25.00	25.00	25.50	67.40	23.60	18.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.42	0.72	-3.82	3	11	2009-01-15 18:05:59	2003-06-09 13:05:48	6	1	2	0	0	11	0	100.10	90	100.00	CHANGED	MSADYPTFKEALEKFKNLESDTAAKDKFNWVFTLENIKTTADVNLASKGLVQLYALQEIDKKINNLTAQVSKLPTTSGSSS.AGAIVPAGSNTQGQYKAPPKKGIKRKYPA	MSADYPTFKEALEKFKNLESDTAuKDKFNWVFTLENIKTTADVNLASKGLVQLYALQEIDKKINNLTAQVSKLPTTSGSSS.AGAIVPAGSNTQGQYKAPPKKGIKRKYPA	0	0	0	0
+6189	PF06362	DUF1067		Protein of unknown function (DUF1067)	Moxon SJ	anon	Pfam-B_15074 (release 9.0)	Family	This family consists of several hypothetical Mycobacterium leprae specific proteins. The function of this family is unknown.	25.00	25.00	25.40	213.20	23.90	22.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.32	0.72	-3.43	2	7	2009-01-15 18:05:59	2003-06-09 13:07:25	6	1	1	0	0	7	0	97.00	97	76.46	CHANGED	MTTPTPQGHDMHTKTPLPRGANNYPHTHACIDIAFSTAQVPSPWHHQHVDQAASTTDMLTCAALIVSTAAKHTKPHRKQAVSHPsTKTPQHSppR.p	MTTPTPQGHDMHTKTPLPRGANNYPHTHACIDIAFSTAQVPSPWHHQHVDQAAsTTDMLTCAALIVSTAAKHTKPHRKQAVSHPPTKTPQHSKTRQQ	0	0	0	0
+6190	PF06363	Picorna_P3A		Picornaviridae P3A protein	Yeats C	anon	ADDA_6741	Family	This family consists of the P3A protein of  picornaviridae. P3A has been identified as a genome-linked protein (VPg) and is involved in replication ([1]).	21.10	21.10	21.10	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.36	0.72	-4.01	4	57	2009-01-15 18:05:59	2003-06-09 14:59:20	6	4	18	0	0	59	0	99.70	76	4.63	CHANGED	phhs.lcE.hphphspLIEthEshhtPpsSsFtCFAsph.s.K.+.pAscKVhsWsps+hpphhsFV.RNKuWhTlhSsloShlSILhLVhhhaKKEcpc-E	..........DAIPYIDEYLNIEMSTLIEQMEAFIEPRPSVFKCFAoKl.usps+.KAuKEVV-WFSsKIKSMLSFVERNKAWLTVVSAVTSAISILLLVTKIFKKE-SKDE.........	0	0	0	0
+6191	PF06364	DUF1068		Protein of unknown function (DUF1068)	Moxon SJ	anon	Pfam-B_14602 (release 9.0)	Family	This family consists of several hypothetical plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	25.00	25.00	35.60	33.60	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.29	0.71	-4.66	3	84	2009-01-15 18:05:59	2003-06-09 15:51:09	7	5	22	0	54	84	0	152.60	49	70.17	CHANGED	MA+HTAALKlGLALLGLSMAGYILGPPLYWHLTEALAtVSAoSCPACsCDCSohPLLTIPptLSNuSFsDCAK+DPEV.....NEDTEKNYAELLTEELKQREAEShEKHKRADsGLLEAKKlTSSYQKEADKCNSGMETCEEAREKAEcALVEQKKLTShWEERARQKGWK-GuTKPsVK	..............................hhlhuls.shhlhGPsLYW+............h..........tp......sh...s........................t.........ts.......s.....CssC.....CDC.....s.s..sl.hpls........ph..pDCu+pDP-l.....scEhEKsas-LLsEELKLpEt.ApEppc+ss.hsLlEAK+lASQYQKEA-KCNuGhETCEEARE+AEusLscp+KLTuLWEpRARQhGWccs.......t.........	0	6	37	46
+6192	PF06365	CD34_antigen		CD34/Podocalyxin family	Moxon SJ	anon	Pfam-B_14609 (release 9.0) & Pfam-B_17463 (release 8.0)	Family	This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation [1]. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an  anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion [2].	24.40	24.40	24.60	24.70	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.41	0.71	-4.67	8	185	2009-01-15 18:05:59	2003-06-09 16:06:09	7	2	43	0	85	157	0	179.50	35	45.08	CHANGED	lLsLsEsosCEcatpsscEpLlc.llCcshpushs..tstColpLApspssppsllhslsscsplssp...hphL+c+ps-LcchGIp-hshpcpusccshpc+..hs.hlIslVshuu.lLLlhslhshYssapRcS.+hspQRLsEELphVENGhHDNPTL-Vh.EsuSEMQEK+.ssLNGEhs-....SWhsP...hss.sKcDl.-....EEDTHL	................................................................hLphscs..C..t.hppp.pstp.Lhp.llCpt.ttphss...tts.Cpl.Lupsp.p.ppllh...slsscptlssp....hphLccp.ppcL.c.clGIpsh..shts.sstpshpp+......hlIsLVs.G..hLLslhhhshYhhh.pRRS.p.stpRL...sE-h.h.sE.NG.psssslpsh..tspsEhQcK..sslNtth.t-.........p...hhs......sp.h+pch.......tDTcL................	0	3	7	29
+6193	PF06366	FlhE		Flagellar protein FlhE	Moxon SJ	anon	Pfam-B_14631 (release 9.0)	Family	This family consists of several Enterobacterial FlhE flagellar proteins. The exact function of this family is unknown [1].	25.00	25.00	31.20	30.90	24.80	23.00	hmmbuild  --amino -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.23	0.72	-4.18	13	533	2009-01-15 18:05:59	2003-06-09 16:11:06	8	1	520	0	49	181	1	97.60	72	81.20	CHANGED	GssLspRG.sssSsPLpssssls..sGhlToVsWRYplsussPsGLpl+LCsto..RCVtLsG.usGpTcuFsG.sAspshpFlaclsGpGpL.PsLpVpSNQVlVNY...R	...............GlTLsaRG.ShSSuPLosp.pPs.......u.G.lMTLVAWRYQLhG.P...TPuGLRVRLCSQS..RCVEL-G.QSGTTsAFuGlsAsEPLRFlWEVPGGGR.L.IPsLKVppNpVIVNYR..........	0	3	15	29
+6194	PF06367	Drf_FH3		Diaphanous FH3 Domain	Yeats C	anon	ADDA_2536	Domain	This region is found in the Formin-like and and diaphanous proteins [1,2].	20.00	20.00	20.10	20.00	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.06	0.71	-4.91	37	1087	2012-10-11 20:01:00	2003-06-09 16:19:41	11	51	230	17	649	1003	4	187.70	26	17.15	CHANGED	suappllcAhhshtthtt..psRF.psllsshcp...................pspplchpsusMthINtllsss...p.-.........lphRlHLRsEhhthGLpcllschcph....cs-pLppplphFcppctcDhp-lh..........p+hc........shpl-hccssplhchl...hpplpcopupshh.lSlLQHlLLh.......psctttt.phhcll-phlsplslppph.t.........ppctslphslppL.......lc	..........................................uachlLpAhsphtphpt..ppRF..psllpthcp........................................................ppsslphtlAsMphINsllpus......-..-..............lpaRlHLR.EF....hphGL.....p....p.hLp..c.L.+ph................cs-p.Lp....hQlp.hap-p.tttD.tpLh..............................................cchc.........................shph...s.h.....c.......ps..p...p...l...hphl...........hpp.l.pc.o.ps.pshh...lShLp+hLhh...............pc...ttt.phhpl.l-phlpplsh.pph.p...........p.php..ht............................................................................................................................................................	1	194	270	470
+6195	PF06368	Met_asp_mut_E		Methylaspartate mutase E chain (MutE)	Moxon SJ	anon	Pfam-B_14693 (release 9.0)	Family	This family consists of several methylaspartate mutase E chain proteins (EC:5.4.99.1). Glutamate mutase catalyses the first step in the fermentation of glutamate by Clostridium tetanomorphum. This is an unusual isomerisation in which L-glutamate is converted to threo-beta-methyl L-aspartate [1].	25.00	25.00	72.00	44.00	21.70	21.00	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.49	0.70	-6.30	5	223	2009-09-11 06:01:28	2003-06-09 16:20:39	6	3	212	6	51	172	5	425.00	53	90.69	CHANGED	lPs+KRFu+tLc+Asp-GKlLsQPRAGVuLLDEHIcLLcsLpcEGuADLLPoTIDSYTRpN+YEcAtlGLc+St-uspShLNGFPlVNHGVcuCR+llcuV...-hPlQVRHGTPDARLLAElslAuGFoSaEGGGISYNIPYoKuVsL-col-sWQYCDRLlGhYEEpGl+INREPFGP.LTGTLVPPSlSpAluIlEGLLAsEQGVKsITVGYGQsGNlsQDIAAl+AL+ElupEYLssauasDlsloTVFHQWMGGFPcDEuKAaulIuhuuslAuhSGsTKVIVKoPcEAsGIPTusuNAsGL+sT+phLsMl-cQ+ls.h-sl-pEpulIKcEs+uILcKlFELGcGDlA+GTV+AFEsGVLDIPFuPScsNAGKhhPsRDssGslRlL-hGsVPlsc-lcphH+c+lcERAchEGRElSFQMVlDDIhAVScGRLIGRP	.............................lPcpKpFuhtLhcAcpcG+TLsQPRAGVALh-EHIcLLcsLp-E..sDLLPoTIDuYTRlNRY-EAtsGIccSl-uGpShLNGhPlVNHGVsuCR+lsEsl...ptPlQlRHGTPDARLLAEIuhAuGFTSaEGGGISYNIPYuKcVoLE+SIccWQYsDRLhGh.YE.Ep.GlcINREPFGP.LTGTLlPPhISpulAIIEGLLAlEQGVKSITVGYGQsGsLsQDlAAIpuLRELucEYhppaGa...sDhcloTVFHQWMG..GFPcDEuKAFulISaGAulAuhuGATKVIsKoPHEAhGIPTstANhpGL+so+Qh.L.s.Mls-.QchP...s.ssl.-hE.h.ElIKpEsRAlLsKVaELG..sG.DlA+GTVhAFEAGVLDVPFAPuttNA.GKllPsRDNsGAIRlL-sGslPlsc-Ih-hH+chlt.ERA+hEGRpsoFQMVlDDI.AlS+u+LlGRP.........................	0	21	37	46
+6196	PF06369	Anemone_cytotox		Sea anemone cytotoxic protein	Moxon SJ	anon	Pfam-B_14701 (release 9.0)	Family	Sea anemones are a rich source of cytotoxic proteins. Cytolysins comprise a group of more than 30 highly basic proteins with molecular masses of about 20 kDa. Cytolysins isolated from the sea anemone, Heteractis magnifica, include magnificalysin I (HMg I), magnificalysin II (HMg II) and Heteractis magnifica toxin (HMgtxn). These are highly homologous at their N-terminals. HMg I and II have molecular masses of approximately 19 kDa, and pI values of 9.4 and 10.0, respectively. Cytolysins isolated from other sea anemones Actinia tenebrosa (Tenebrosin-C, TN-C), Actinia equina (Equinatoxin, EqT) and Stichodactyla helianthus (ShC) exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities [1].	25.00	25.00	25.00	25.20	20.90	24.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.21	0.71	-4.86	3	46	2009-01-15 18:05:59	2003-06-09 16:28:07	7	1	24	19	21	55	0	153.10	36	87.33	CHANGED	-VAGAVIDGASLoF-ILcKVL-ELGKVcRKIAVGVDNESGtTWTALNTYFRSGTSDVlLPacVPNoKALLYoGRKS+GPVATGAVGVLAYhMSsGNTLAVMFSVPFDYNWYSNWWNVKIYcGKRRADQ+MYEELYYN.NPaRGDNGWapRNLGY.GLKhRGFMTSuG-AKLpIHISK	...............................................................................hpRplslthpN.oshph.hs.t...sYh.SGtsp..ls..l...tpshhhshpKspGs.sATGuVGVlsYt..h......ss......u......p......T......lAlMFSVPaDYNLYSNWasVtl..ap.sp+..p..sDpphYcphY.s.........s..s.....h....cs.c.s.sht..pt..........uh.....ul.......c.......hcuhMss.GpAhlplcl............................................	0	3	8	17
+6197	PF06370	DUF1069		Protein of unknown function (DUF1069)	Moxon SJ	anon	Pfam-B_14815 (release 9.0)	Family	This family consists of several Maize streak virus 21.7 kDa proteins. The function of this family is unknown.	25.00	25.00	28.20	204.90	20.50	18.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.24	0.70	-4.96	2	13	2009-12-01 13:51:58	2003-06-09 16:30:04	6	1	13	0	0	7	0	197.60	99	100.00	CHANGED	MGSKCKAIAGGNDHVQSSSLDGTNSSVRYILPLRSHSQPTRELVEVDVALARLPTsIRWRNVRTNPPVGLHVEQPTPFHHEAMTQLPAHLPCRRPGFEGVRVGKYSLRGRSLSAGSGVIHQPHHTGSGVGVPAGCRVSNEVVVDGNLVRQSLAGVAVAlVRSSGIGVDEVTYASGGDRYHGGPGMLECLDLEGWPIGLAASPLQPS	MGSKCKAIAGGNDHVQSSSLDGTNSSVRYILPLRSHSQPTRELVEVDVALARLPTCIRWRNVRTNPPVGLHVEQPTPFHHEAMTQLPAHLPCRRPGFEGVRVGKYSLRGRSLSAGSGVIHQPHHTGSGVGVPAGCRVSNEVVVDGNLVRQSLAGVAVALVRSSGIGVDEVTYASGGDRYHGGPGMLECLDLEGWPIGLAASPLQPS	0	0	0	0
+6198	PF06371	Drf_GBD		Diaphanous GTPase-binding Domain	Yeats C	anon	ADDA_2536	Domain	This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.08	0.71	-4.94	20	1367	2012-10-11 20:01:00	2003-06-09 16:33:03	8	48	240	17	827	1229	2	151.50	21	17.18	CHANGED	htps.s-cplpphFtcllc-h...sLsccc+...cshhshshpcKWphlhpcppsphpt.............................pppspptSPcaYlcpLpssshsp..............ppLcSLpVuLpopPluWVppFhphpGhssLhslLpphppcpsps............p.shcpcacll+CLKAlMNNpaGhcpsLs..pppslhhlupSLsosp.pTpphsh-lLosLCl	.............................................................................................................................................th............sls...p.t......t...h...t.h..s..hK.hphh.p...................................................................................................................................tt.......st.hh.p.h.t............................................phlppL..c...ht......L......p...........s......p....h.........s.........WlppF...........t..........p..Gh....shLhp....hL.tt.......h............t.........................................................................p....h.hlhC.l.+AlM.......N...p.p..................G.h.......p...h..h.ht............p.p.s.......l....ls.u.l.....s.....tp.........t...hhh...s..h..clLshlC...........................................	0	248	348	591
+6199	PF06372	Gemin6		Gemin6 protein	Moxon SJ	anon	Pfam-B_14816 (release 9.0)	Family	This family consists of several mammalian Gemin6 proteins. The exact function of Gemin6 is unknown but it has been found to form part of the Pfam:PF06003 complex. The SMN complex plays a key role in the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and other ribonucleoprotein particles [1].	25.50	25.50	25.90	25.80	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.24	0.71	-4.93	2	70	2009-01-15 18:05:59	2003-06-09 16:41:22	7	1	63	2	51	78	0	152.90	40	95.14	CHANGED	hspWhchS..papsas.K.V+llhs-.+phcGWlhssDPVStsllLsp.hE.GthSsoslhGHulpphEh.pEh-aph...EKL.asatph-spGa...DLEc++oslh+WLEKN+lsVT.p...pchlCVhGVLsI-PPYs.EsCpSSN.IILpRIQcLIQsh.sspp	............................tW..hsPhpapsYlhKpV+Vpss.-tpcacGWlhTsDPVS......usl.VLl.....shhE.c.u.p..h..o.l.pslhGHAVpsVEsls..-.u...-.....p.....ps+....E+L...chFh..st...-.s..p.u..hS......E-...LccRKs.....sL+cWLccN+IPlsE....pucstpoL.sVA.GVLTI-PPYsPEsCsSoNpIILuRlQsLIpsh................	0	15	18	34
+6200	PF06373	CART		Cocaine and amphetamine regulated transcript protein (CART)	Moxon SJ	anon	Pfam-B_15325 (release 9.0)	Family	This family consists of several cocaine and amphetamine regulated transcript type I protein (CART) sequences. Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots [1]. 	21.10	21.10	21.60	22.40	19.80	18.20	hmmbuild  --amino -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.56	0.72	-4.02	9	78	2009-09-10 15:42:36	2003-06-09 16:46:50	6	2	44	1	33	82	0	70.40	66	65.26	CHANGED	sss.spEK-L...ltALpEVLEKLQsKRIs.hEKKhGpVPhCDlGEQCAlRKGuRIGKLCDCPRGosCNaFLLKCL	......................p..p.ppEKpL...l-ALQEVLcK.....LcoKRI..PlaEKKaGQVPhCDsGEQCAVRKGARIGKLCDCPRGosCN.FLLKCL..........	1	1	7	15
+6201	PF06374	NDUF_C2	NDUFC2; 	NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)	Moxon SJ	anon	Pfam-B_15334 (release 9.0)	Family	This family consists of several NADH-ubiquinone oxidoreductase subunit b14.5b proteins (EC:1.6.5.3).	21.70	21.70	21.90	24.10	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.68	0.71	-4.09	5	104	2009-01-15 18:05:59	2003-06-09 16:51:15	6	2	82	0	56	110	0	105.50	39	95.41	CHANGED	uRsss-PLcFLPD....EARSLPPPKLsDPRLlasGlLGYCoGLhDNhlRRRPVhhAGLHRQLLFlTuFVFAGYYalKRcNYhYAVRD+-MFuYIKLHPEDFPEKDKKTYGEVLEsFHPVR	....................................s.........hLss....csp.LPP..Ptlhs.st..lahGh.hGassu..l..lsNhl....p....RRPhh.uGlHRplLasoshhhhGYalsKhpshh....aAt+DpphhpYlcLHPEDFs...c...p.-+..Kpau..-lhE.ahPlR........	0	14	19	38
+6202	PF06375	BLVR		Bovine leukaemia virus receptor (BLVR)	Moxon SJ	anon	Pfam-B_14559 (release 9.0)	Family	This family consists of several bovine specific leukaemia virus receptors which are thought to function as transmembrane proteins, although their exact function is unknown [1].	26.40	26.40	26.90	26.90	25.00	25.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.33	0.71	-4.39	16	148	2009-01-15 18:05:59	2003-06-10 10:48:18	6	9	89	2	77	143	0	137.40	48	14.42	CHANGED	.opEElc+RREARphEQsNNPaYLKuuspspsutss.........htsh-cIPlspI-Lsl....PLc.....lsG.......hhtSDKYlptppppp..........pcKscK........KcKK++++.....pKcupph....sss---D......tPlchVNpshtE.MPEGAp.SD...pcccstcssDPHRALDIDL-	....................................................h.sEEELtRRREAR+pEQANNPaYlKSSPospKphpss..............sslE+IP..VspIDLoV....PLK..............VPG.......hshSDpYlKh--cR+.........tp.cKcK+..........K+K+pccc.....cKttp+hpts.toES-EDh.....sPsp.Vshss.tE.MPEsAhsSD.....-...-cpDPNDPa+ALDIDLD..................	0	26	31	58
+6203	PF06376	DUF1070		Protein of unknown function (DUF1070)	Moxon SJ	anon	Pfam-B_14060 (release 9.0)	Family	This family consists of several short hypothetical plant proteins of unknown function.	25.00	25.00	30.30	30.30	21.20	15.90	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.51	0.72	-4.09	15	109	2009-01-15 18:05:59	2003-06-10 10:50:05	7	2	18	0	64	105	0	34.80	61	50.00	CHANGED	Asus...t..s.DGpslDQGIAYlLMhsALslTYLhH	............APAP.....AP.oSDGpuIDQGIAYlLMllALlLTYLlH..	0	4	35	50
+6204	PF06377	Adipokin_hormo		Adipokinetic hormone	Moxon SJ	anon	Pfam-B_14600 (release 9.0)	Family	This family consists of several insect adipokinetic hormone as well as the related crustacean red pigment concentrating hormone. Flight activity of insects comprises one of the most intense biochemical processes known in nature, and therefore provides an attractive model system to study the hormonal regulation of metabolism during physical exercise. In long-distance flying insects, such as the migratory locust, both carbohydrate and lipid reserves are utilised as fuels for sustained flight activity. The mobilization of these energy stores in Locusta migratoria is mediated by three structurally related adipokinetic hormones (AKHs), which are all capable of stimulating the release of both carbohydrates and lipids from the fat body [1].	22.90	22.90	22.90	24.20	22.50	22.00	hmmbuild  --amino -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.44	0.72	-3.82	15	60	2009-01-15 18:05:59	2003-06-10 11:50:57	6	4	44	0	22	63	0	52.90	42	44.60	CHANGED	QLNFoPsW..GKRuususu................................tssC+s.ss-slhhIY+lIQsEAp+llpCpc	.QLsFSPsW..GKRSssssu................................tssC+s...ss...-sLhtIY+hlQsEAp+hlpCpp........	0	8	10	19
+6205	PF06378	DUF1071		Protein of unknown function (DUF1071)	Moxon SJ	anon	Pfam-B_14587 (release 9.0)	Family	This family consists of several hypothetical bacterial and phage proteins of unknown function.	20.50	20.50	26.80	27.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.05	0.71	-5.10	11	191	2009-01-15 18:05:59	2003-06-10 12:28:58	6	1	183	0	11	110	95	162.20	42	77.30	CHANGED	pohFEpLusIcVsc+lEK....KssLoYLSWAaAWsplKKthPsATapl+cFst.th.t.sh.........sahcophGahVpVsVTl....cslocpphLPVhDaRNKsl.................tK..PosFDINpolhRCLVKAlAhaGLGLYIYuGEDLP.........ch.pp.pp.pshppp.tpppsthsp	...................................olFEpLsshsVN-+hEp..............K...s..sLsYLSWuaAapElKKlpPssohcltEas..s.p.s.sY..........ahsstpGa.hVpVuVTV....csh..TcspaLP..VhDaRNK.ul...............................tK..sTsFDINKuhpRChVKA.lAh.H.GLGLYIYsG.EDL.Ppss...p.tclp-c.pph.s.pQphtc.tsh..ppt..........................	0	3	8	9
+6206	PF06379	RhaT		L-rhamnose-proton symport protein (RhaT)	Moxon SJ	anon	Pfam-B_14617 (release 9.0)	Family	This family consists of several bacterial L-rhamnose-proton symport protein (RhaT) sequences [1,2].	19.00	19.00	19.70	19.70	18.90	17.70	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.36	0.70	-5.46	2	639	2012-10-02 19:55:49	2003-06-10 12:32:38	7	2	582	0	70	330	44	313.70	70	99.30	CHANGED	MsNAIhhGIhWHLlGAASAACFYAPFKQVKpWSWETMWSlGGlVSWLILPWTlShLLLPDFWtYYGpFsluTLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIlGTLMTPIlpGpFDVLltT.GGRMTLLGVFVALIGVuIVohAG.LKERtMGIpAEEFNLKKGLlLAVMCGIFSAGMSFAMsAAKPMHEAAuALGlssLYVALPSYVlIMGGGAllNLuaCFIRLAplpNLSlKADFSlA+PLlIoNILhSALuGLMWYLQFFFYAWGHA+IPtQYDYMSWMLHMSFYVLCGGlVGLlLKEWKsus++PVAVLslGClVIIlAANIVGLGMAu	.....................................................MspAIhhGIhWHLIGAASAACFYAPFK+VKcWSWETMWSV.GGIVSWlILPWsISALL.LP......s...FWA...YYu.pFsl.S...TLLPV...FLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPI......I........N.......G........N..F...D.V.L.Is..T.E.G..G..R...M.TLLGVhVALIGVGI.VTRA..GQLK.....E...R.K.M.........G.....I.....K.......A......E......E......F.....NLK......K.....GLlLAVMCGIFSAGMSFAMNAAKP.M....HE.AA.A....A.L.......G.V.........D....P.....LYVALPSYVlIMGGGAllNL...GFC..FIRLAKVK..........sL.....S..l...KADFS.L.....AK....P....LI..IpNlLLSALGGLMWYLQFFFYAWGHARIP..AQ..YDYh..S..WMLHMSFYVLCGGlVGLVLKEWpNAGRRPVsVL..SLGCVV..IIlAANIVGlGMA........................................................................	0	23	47	59
+6207	PF06380	DUF1072		Protein of unknown function (DUF1072)	Moxon SJ	anon	Pfam-B_14592 (release 9.0)	Family	This family consists of several Barley yellow dwarf virus proteins of unknown function.	25.00	25.00	35.80	35.60	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.17	0.72	-4.29	8	42	2009-01-15 18:05:59	2003-06-10 12:58:32	6	1	7	0	0	41	0	38.70	54	93.28	CHANGED	MDDLHVIAVClLAhTVLoG....lGAVhGCChGChpss.sssps	MDDLHVIAVCl..LAhTVLoG....luAVlGCChGChps..su.......	0	0	0	0
+6208	PF06381	DUF1073		Protein of unknown function (DUF1073)	Moxon SJ	anon	Pfam-B_14928 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins. The function of this family is unknown.	26.40	26.40	26.40	28.10	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.80	0.70	-6.00	25	555	2009-01-15 18:05:59	2003-06-10 13:00:25	6	4	357	0	63	498	42	335.50	22	77.28	CHANGED	shsphphtuhYpsshls+phl-hsA-DhsRpshplputst....................cphpplcsphcclplppplp-slpasRLaGuuhllhtl..........cspphspPl..s.-plttuuhctlsslcthhlpss...hlspsshussaGcPphapl.s.st..............stcIHpSRllhh..........................ththPh..pht+.s.phaGpSllpp.lh-tlpshDsotsusupL.......lactplssl+ssshpplhsssp...splhcclshhpphcu.pulhllDs.......p-chpphssshu.GLc-llsphhptluusucIPhs+LhGpsPsGhNuoG-uDhcsYYDplpuhQ-pclpsslcpLhchlhhSthu........spslpa..cFsPLhpho-p-+A-ltpppu-uspthlss	.................................................................................................................h........thY.p.shhhtphl-..u-Dhh+psh..lputt.....................cphsthp.t.thpcl...p..lpptlhpslh....t...R..haGh.uhlhlhs..........pttshppPl.......p.c..th...hthchl.h.h...ph.h....lsssh..hhp.csh...u........sshs...p.sp.a.l.........................uhcIHcSRllhh..........................th.h.h.....p.s...hh...G.shlpp..lh-tL.pshssshsu.ssph....................lhpttlp..hhpsp........p.....hpphhs..tt..........t...................psltp.pl.phlpphp.sNp.G.hhhhss..........p-ph-shp.h......s.hu.sLc-h.l....s.httpluussphPhs+Laupp.spGhsusGcuDh..pNYYDhlpu....lQE....p.....hhps..sh....p+...lhchht..hs..............th.h..cFssLh.hoppppsphthphsphhpth...h...............................................................................	0	13	33	46
+6209	PF06382	DUF1074		Protein of unknown function (DUF1074)	Moxon SJ	anon	Pfam-B_14962 (release 9.0)	Family	This family consists of several proteins which appear to be specific to Drosophila melanogaster. The function of this family is unknown.	21.30	21.30	21.40	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.46	0.71	-4.31	3	76	2012-10-02 14:16:02	2003-06-10 13:06:12	6	4	15	0	41	84	4	103.50	23	66.99	CHANGED	Mussplptsp.hhst.lSluup...D.sspthsphhsh.IR.Rs.phstshhphtp.++htthGRKRGRKEYCPPIYKRQKVARVTNNGYLNFMTEYKKRFYGLSPQDMVHYAAKQWTQLSMAEKEAFKSKKPSTITLKSPAQYVACEMKSDVAGGQQSSCQRQSPSARLRESERRSSRSKTLCRSA	................................................t................................................................................................................s.................+p..p..p...u.....l..o.s....s.uYlNFlRpa....++....+....a..s....s..Lps.p-llppAA+tWspLoptcKpta...cp.................................................................hh...t............................................	0	7	7	30
+6211	PF06384	ICAT		Beta-catenin-interacting protein ICAT	Moxon SJ	anon	Pfam-B_15027 (release 9.0)	Family	This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions [1].	25.00	25.00	28.30	26.60	24.50	20.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.51	0.72	-4.20	8	132	2009-01-15 18:05:59	2003-06-10 13:28:22	6	4	77	3	83	108	0	76.50	47	44.90	CHANGED	MsRDltlGKlucDlYsQQKVEILhAL+KLGEpLoP-EEAFLsspAuAshSQFEKVop.slGuGcK..lhAhAuSplEsspK	.............MsR-hhsGKhsc-hYhQQKVElLhALRKLGppLTssEEtFLps...A..Gssh..SQ.hpplsp..s...lspGsc..lhAhup.pscctp....................	0	22	28	52
+6212	PF06385	Baculo_LEF-11		Baculovirus LEF-11 protein	Moxon SJ	anon	Pfam-B_15073 (release 9.0)	Family	This family consists of several Baculovirus LEF-11 proteins. The exact function of this family is unknown although it has been shown that LEF-11 is required for viral DNA replication during the infection cycle [1].	21.20	21.20	27.30	27.00	21.10	18.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.05	0.72	-3.89	24	60	2009-01-15 18:05:59	2003-06-10 13:31:41	7	1	58	0	0	54	1	94.50	40	79.17	CHANGED	CLTRS-VYAllREsINp+K+sh-scNVsAHl.-.ssFss.ppYIRssls+hhIhpucppp...+plshHtpRlpplFsLp.poLcpEYpts.hs+h.tspp	CLTRSEVYALlREsINp+K+shpscN.VsAHl.-..ssFps.ppYIRtNls+.hhllsucppp...+plshHtcRlsplFsLp..p...oLcpEYpps.ls+httt.p......	0	0	0	0
+6213	PF06386	GvpL_GvpF		Gas vesicle synthesis protein GvpL/GvpF	Moxon SJ	anon	Pfam-B_15376 (release 9.0)	Family	This family consists of several bacterial and archaeal gas vesicle synthesis protein (GvpL/GvpF) sequences. The exact function of this family is unknown.	23.60	23.60	24.20	24.20	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.62	0.70	-4.79	68	377	2009-01-15 18:05:59	2003-06-10 13:37:45	6	6	145	0	171	417	19	222.00	22	91.36	CHANGED	h.sp.ulYlYuIl...sssssh............t...............hsh.Glssss..Vhs....l..phssluAlVSssstsp...pstccsl...........hsHppVlcplhcp.s..slLPh+FGslh.ps.......tcs..lpphL.psttcphpptLsclpGphEhulKlhhsp.t..hhpplhtps.plpthptphttt..........s..stsh..pph...phsphlpptlppcppphspplhctLpslutpsp.pcs....................................hs-chllNsAaLVspsctspFsptlcplspphss...lslchoGPhPPYsFs..shph	......................................hYlYulh.........tt...................................th..Glssts...lhh...........l.......thssluAlVu.p.ss.tt....pstccpl................hsHppVlptlhtt..s...slLPh+FGslh..ts........pcs.lpphL.ptptpphtptLpplpG+sEhslKshhsp......tth..tts.th....tt..ttth.ttt..................s...sts.a.tph....phtphhtpthttptpphspplhptLpshu.psthpts.............................................spp.lhshuaLlsps......pt......s.t.Ftptlppltpphs...t......hplchsGPhsPYsFst.............................	0	67	130	164
+6214	PF06387	Calcyon		D1 dopamine receptor-interacting protein (calcyon)	Moxon SJ	anon	Pfam-B_15400 (release 9.0)	Family	This family consists of several  D1 dopamine receptor-interacting (calcyon) proteins.  D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling [1]. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) [2] and schizophrenia [3].	25.00	25.00	38.30	38.20	22.10	21.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.03	0.71	-4.92	3	132	2009-01-15 18:05:59	2003-06-10 13:45:12	6	2	41	0	72	117	0	169.40	55	98.17	CHANGED	MVKLGsNFuEKGuKpPulEDG..FDTVPLITPLDVNQLQhusPDKVVVKT+TEYQP-p+sKGKtRsPpIAEFTVs.p.t.scRh.solLVuFALAFLuCVVFLVVYKAapYD+.oCPDGFVLKHKpCIPtoLEuYYoEQDPSuRc+FYTVIuHYsLAKQSsTRuluPWhSuhuttK................................sh+EsEsPcKuu	............MVKLGsNhu-KssKtPss.....EDG..FpTlPLITPL-VspLQhPsP-..KVl.V.K.T+TEYps-pK.KGKhRsPKIAEFTls...t.sc.+h.solLlhhALAFLsClVFLVVYKsapYD+.uCP-GFVhK......pppCIPtuL-uYYopQ....D.ssuR....p+....FYTVIs..HYslAKQohoRuluPWhos.hut.p................................s.pEscsspp..u...................................	0	6	9	25
+6215	PF06388	DUF1075		Protein of unknown function (DUF1075)	Moxon SJ	anon	Pfam-B_14186 (release 9.0)	Family	This family consists of several eukaryotic proteins of unknown function.	25.00	25.00	25.20	27.90	20.40	24.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.86	0.71	-4.54	12	137	2009-01-15 18:05:59	2003-06-11 11:03:00	6	1	80	0	83	122	0	130.30	34	90.73	CHANGED	thGphhR.h......Ruhuos.phpc..............tt.stpsPtus...pph.ppsst.++Psph-K+hLlWoGRaKo.-EIPphVS.EMl-suRNKhRVKlsYlMIuLTlluChh.MllSGK+AscR+ESlsphNL-h+s+apEt........uhpupuc	...................................................................t..................................................tp......tsts....spt.h.......pclsh...++Posa-KKlLlWoGRFKpt--IPph..lS...EMl-sA+NKhR...VKlsYlMIuLTllGChh.hlhpGK+AspRp..E...olsphNlc++tch+..Ect..............t.......................................	0	17	23	49
+6216	PF06389	Filo_VP24	Filovirus_VP24; 	Filovirus membrane-associated protein VP24	Moxon SJ	anon	Pfam-B_15734 (release 9.0)	Family	This family consists of several membrane-associated protein VP24 sequences from a variety of Ebola and Marburg viruses. The VP24 protein of Ebola virus is believed to be a secondary matrix protein and minor component of virions. VP24 possesses structural features commonly associated with viral matrix proteins and that VP24 may have a role in virus assembly and budding [1].	25.00	25.00	333.70	333.60	20.20	19.30	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.75	0.70	-5.16	3	32	2009-01-15 18:05:59	2003-06-11 11:17:39	6	1	20	4	0	28	0	252.00	62	100.00	CHANGED	MAKATGRYNLVsPK+-hEKGVl..FSDLCNFLlTPTVQGWKVYWAGlEFDVsQKGMTLLsRLKoNDFAPAWAMTRNLFPHLFKNPpSsIQoPIWALRVILAAGLpDQLLDHSLIEPLoGALsLISDWLLTToToHFNlRTppVKDQLShRMLSLIRSNIlNFINKL-TLHVVNY+GLLSSIEIGTooasIIITRTNMGFLVEVQEPDKSAM..-o++PGPVKFSLLHESsLKPaopscpSuhpSLIMEFNSpLAI	MAchosRYNL..PppshEKuls..Lsshspalhp.oltGWpVhWush.FclsppGMsLLH+LKoN.hsPtWp.TRNLFsHLFpNPpSTI.pPhhALRllLusuLpDQ.LpQSLI.shpuhlphlS-WLLhpsTothplpsphlt..Lo.cMhpllhuslhpFhNKL.sLHVVN.pGh.SSIEIthosppIIITRsNMGFLVEVpc.Dhpsh..pohhstsVhFuLltEusL+taoQhppup..sLh..hNSplAI	1	0	0	0
+6217	PF06390	NESP55		Neuroendocrine-specific golgi protein P55 (NESP55)	Moxon SJ	anon	Pfam-B_16185 (release 9.0)	Family	This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins [1].	22.60	22.60	22.80	22.70	22.30	22.50	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.00	2	34	2009-01-15 18:05:59	2003-06-11 11:26:26	7	6	21	0	16	42	3	183.70	46	67.10	CHANGED	MDRRSRsQ.hRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALAoSssRAQQR.AAQRRoFLNAHHRS.....AAQVhPEs..sESDHEcp-hEPpL..PEC.EYpp--a-hE..SETEsES-IESETEh....ETEs-TAPTTEPETEPEDE.G...P+tsTFpQSLTpRLpAL+LpSsDASPpRA.PoTQEsESsppGEEPp....DpDPRDPEEp.E.+cEEppQ.+RCKs++Ps.RRD.SPESPs++GsIPIRRH	....................................................................................................................................................s.sp...spSDp-pp..phc.pL..sEs..-ap.p-h-hE..oETEsES-lEoET-..h....ETEs-Tt.PtTEPETE..PED-pG....P...+.tsTF......sQ..SLTpRLpAL+lp.SsDsp.pps.PosQpspssppGEE.p..P....pD.+sPEEp..-.+.p.....pQ.+RCKs+.+.s..RRD.SPESPs++GPIPIRRH...........................................................................	1	1	4	7
+6219	PF06391	MAT1		CDK-activating kinase assembly factor MAT1	Finn RD	anon	Pfam-B_16773 (release 9.0)	Family	MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH [1].  The domain found to the N-terminal side of this domain is a C3HC4 RING finger [1].	25.00	25.00	27.00	27.00	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.40	0.71	-4.73	6	318	2009-01-15 18:05:59	2003-07-03 16:31:22	8	7	278	1	239	314	1	168.20	31	55.13	CHANGED	LRKspFRsQlFEDspl-KEV-IRK+lhKIaNKpp-DFs.uL+EYNDYLEElEpIlaNLspslDl-pTccKlctYcKpNK-sIt+N+t+hssEQc.LEptLchE+cpcpc+R.thpp-Epppcht.KcpsKppllD-LpoSshssshlls.p+Ksps.hphEtthcK.cph+psshssuh+pu...phshsslp+lcEthasapPlp	...............LR+spF+hQhF-D.tV-KEV-IR+RVhpl.aNKp--DF....s.oLc.-.YNDYLE..c.......l..E-I..laN.Lss...s..l..D...l..t...p..T...ctclp..pYpp-Np.p.I.t.pNp.t.+.h..........pp.-ppt........hp.ph.ph.Epp.t...p..p+..+...tp...tptpph..t.tt+pthlspLt..........t.u.....p..........s...t.hlt...t.ttt.....t.p.................................................................................h............................................................	0	76	130	197
+6220	PF06392	Asr		Acid shock protein repeat 	Finn RD	anon	Pfam-B_20230 (release 9.0)	Repeat	The Asr protein is synthesised as a precursor and the cleavage is essential for moderate to high acid tolerance [1].	21.00	21.00	21.10	21.00	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.33	0.72	-6.55	0.72	-3.57	8	470	2009-01-15 18:05:59	2003-07-03 16:34:35	6	3	450	0	18	119	1	19.30	85	18.79	CHANGED	HHKKQH....KsAsEQKAQAAKK	...HH.KKQH......KAAPAQKAQAAKK.	0	1	3	8
+6221	PF06393	BID		BH3 interacting domain (BID)	Finn RD	anon	Pfam-B_16321 (release 9.0)	Domain	BID is a member of the BCL-2 superfamily of proteins are  key regulators of programmed cell death, hence this family is related to Pfam:PF00452 .  BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event, exposing  the BH3 domain and significantly changing the surface  charge and hydrophobicity, which causes a change of  cellular localisation [1].	25.00	25.00	27.20	48.50	24.30	19.80	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.28	0.71	-4.95	7	65	2009-01-15 18:05:59	2003-07-03 16:42:05	6	2	36	5	27	64	0	163.70	51	94.68	CHANGED	M-.cV.sNGs....-phpphLlhuFLp...psscspFpcELpsLupE..LPs...th.tp..sELQTDGNRsu+..hpsthEs.DuEspE-llRpIAtpLAphGDcL-+p..I+PtlVsuLssphhNpoLsEE-hppsLAsslppLhpohPsDhEpEKshLllsMLLsKKlAspsPSLL+cVF+TTVsFIsQNhhsYlcpLsRp..-	......................ts-phTsLLlauFLp...ssssspFpcELcsLGpE.......Lss......hpt......-ELQTDGNRsS+.....hhtchEs.DSEsQ.......E-..llppIAtpLAplGDph-+u..I.PtLVssLAhQhhNsshSEEDRpppLAsAlEplh..Qsh..Pt..DhEpEKshLlLuhLLAKKVAsHoPSLLRcVF+TTVNFINQNLhsYlRsLsRN...................	0	1	2	7
+6222	PF06394	Pepsin-I3		Pepsin inhibitor-3-like repeated domain	Finn RD	anon	Pfam-B_13438 (release 9.0)	Domain	Pepsin inhibitor-3 consisting of two domains, each comprising an antiparallel beta-sheet flanked by  an alpha-helix. In the enzyme-inhibitor complex, the  N-terminal beta-strand of PI-3 pairs with one strand  of the active site flap region of pepsin [1]. The two domains are tandem repeats of sequence, and has therefore been termed repeated domain.	20.60	20.60	21.00	21.20	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.49	0.72	-4.32	13	63	2009-09-11 00:18:44	2003-07-03 16:51:00	8	2	18	2	35	64	0	70.30	29	53.54	CHANGED	P+ss+p.oFsThssT.sthhhsGChVpsN+lYlsstalRDLTssEtpELpsFcpchssYpstlppplppphpsLhus	....................p..sFss.hsso.s.hhhsGChVpsN+lYssuhhlR-LTspEhpELppappchstYpp.lppthppphpsh............................	0	14	18	35
+6223	PF06395	CDC24		CDC24 Calponin	Wood V, Studholme D	anon	Pfam-B_32837 (release 8.0)	Domain	Is a calponin homology domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.67	0.72	-3.92	17	130	2012-10-03 10:10:54	2003-07-03 16:58:00	6	10	124	0	99	201	1	89.40	42	9.83	CHANGED	DPVTpLWphFppGsPLChlFNslpP..cp.LsV.......ssss-h+hCKtulYcFlhusKpcLsass--hFsISDlaussTsshlKVlpVlsplL	.........DPVspLWphhRpGhPLhhlaNulp.P.....p.p...L.s.l........................ssss-t.+..tsKtu.lacFl.AChp....c...L.s....a.ssp......-hFhIoDL.a...u.s..s.ToGFVKVlpsVsplL.................	0	26	55	87
+6224	PF06396	AGTRAP		Angiotensin II, type I receptor-associated protein (AGTRAP)	Moxon SJ	anon	Pfam-B_15509 (release 9.0)	Family	This family consists of several angiotensin II, type I receptor-associated protein (AGTRAP) sequences. AGTRAP is known to interact specifically with the carboxyl-terminal cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to regulate different aspects of AT(1) receptor physiology [1,2]. The function of this family is unclear.	25.00	25.00	26.50	26.00	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.10	0.71	-4.55	6	84	2009-01-15 18:05:59	2003-07-03 17:24:07	6	4	70	0	53	93	0	144.00	36	83.59	CHANGED	MELPAVNLKlIlhVHWLLToauCls..hsGuYuasNFsILAhGVWAlAQRDSIDAIpMFLsGLluTIFhDllhIuIaaspss.......ltDhhRFSuGMAIlsLlLKPlSChhlYHMaRERGGph.htpGFlGsSp-R.SSYQsIDu.-sPADPhss.ps.u.ss.RGY	.......................t.PhlplKsIhhlHalLsoWuhl...s....hsuuYtasNFslLshulWAltp+..DS.l-Alph.hLs.hhshoIhhDIlplulaa.sp.hs............h..tsh.+FusuhuIlsLlL+.PlSshhlY+hapcR....GGph.......h....s.h..t...ssppp.puYpsIDp........P.tt...................................................................	0	17	20	34
+6225	PF06397	Desulfoferrod_N		Desulfoferrodoxin, N-terminal domain	Finn RD	anon	Pfam-B_11142 (release 9.0)	Domain	Most members of this family are small (approximately 36 amino acids) proteins that from homodimeric complexes. Each subunit contains a high-spin iron atom tetrahedrally bound to four cysteinyl sulphur atoms This family has a similar fold to the rubredoxin metal binding domain [1]. It is also found as the N-terminal domain of desulfoferrodoxin, see (Pfam:PF01880).	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.95	0.72	-4.56	8	428	2012-10-03 19:45:42	2003-07-04 09:46:30	7	6	397	31	132	306	13	35.50	48	24.00	CHANGED	scphpVYKCplCGNIVEVLcsGGGpLVCCGcPMcLh	.......h...hchYKCppCGNl.V.E.VhpsG.GG.p..LsCCGc.Mch.....	0	65	116	129
+6226	PF06398	Pex24p		Integral peroxisomal membrane peroxin	Wood V, Studholme DJ	anon	Pfam-B_56111 (release 8.0)	Family	Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolism and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p [1].	24.50	24.50	24.60	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.55	0.70	-5.66	54	690	2012-10-01 21:10:52	2003-07-04 09:52:51	6	64	241	0	464	811	3	261.70	22	35.45	CHANGED	s.hosslLsssssplsppLuhhasal...scllpllTWossshhhohLllhsahslh.Yh..............thl.h.hshllhslhh.uhlaha....ts.h..............................................................................tp.pppPoLc......................................................-llhsLp...............slps+sshllpshstls.hh.........hpspsloshlFhhlhloslhlhls........hhllsh..+hlhlhsG.shlloaHsphpcshtphh...............hlsuhchp.............................................................hp....phh.shhpp..chh......h.ps.ps.p......................hph.laE.QR+h.luh...uWos.hhos-chshs.......sc...thsp.Ps..........................h-chp.Pp.....................sWcWs-..........pcWclDhsspthlp............sppc................GWlY..........................................ss...appsph.pDuhscasRRRRWhR	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hph.tlaENQR....h.....h...s...........sW.s..s........t....hh...s...-.ch.....sao..............st...ttpp.................................................................hcsh.p..h.Pp......................tWcW.s..............................cWplDh...s..t.hh..............................................................................ptpt......................................GWhYs...............................................................sh..........t..p.p....t...tcph.p.....ph.sRRR+WhR....................................................................................................	0	129	242	373
+6227	PF06399	GFRP		GTP cyclohydrolase I feedback regulatory protein (GFRP)	Finn RD	anon	Pfam-B_63435 (release 9.0)	Domain	Tetrahydrobiopterin, the cofactor required for hydroxylation  of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism  is mediated by the regulatory subunit called GTP cyclohydrolase  I feedback regulatory protein (GFRP) [1].	25.00	25.00	28.20	32.70	23.90	23.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.80	0.72	-4.39	4	69	2009-01-15 18:05:59	2003-07-04 10:35:58	8	1	53	35	39	61	0	80.00	67	93.65	CHANGED	PYlLISTQIRhEsGPThVGDEaSDPpLMshLsAcKhpsLGNNFpEYaVc-PPRlVLsKL-+lGYRVlSMTGVGQTLVWCLHKE	......PYlLISTQIRhEsGPTMVGDEpSDPcLMpaLGApKpssLGNNF.EYaVsDPPRlVLDKLE+pGFRVlSMTGVGQ..TLVWCLHKE.........	0	10	13	22
+6228	PF06400	Alpha-2-MRAP_N		Alpha-2-macroglobulin RAP, N-terminal domain	Finn RD	anon	Pfam-B_44514 (release 9.0)	Domain	The alpha-2-macroglobulin receptor-associated protein (RAP)  is a intracellular glycoprotein that binds to the 2-macroglobulin  receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of  all currently known ligands of these receptors [1].  The N-terminal domain is predominately alpha helical [1]. Two different studies have provided conflicted domain boundaries [2,3].	27.30	27.30	27.40	44.40	26.40	27.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.51	0.71	-4.44	10	108	2009-01-15 18:05:59	2003-07-04 12:32:49	6	3	73	7	51	104	0	113.90	50	33.65	CHANGED	lsLl.hlllhhsshssuspuuKYSREsN.........EshssscRcsscEFRMsKLNQlWEKAQRL+LoslKLs-LHoDLKIQEKDELsWKK.LKs-GhDcDGEKEA+LRRsLslIho+YGL....DG+KDscplc	.....................h....h.hhhh..sstttusKYS+EtN..........p...s.ssh+.p.....tp.FRMtKLNQlWEKApR.h....+..L.osV+Lu.-LHuDLKIQE+DElsWKK.LKs-GLDc....DGEKEA+LpRsLs...VILu+YGL....DG++Dsp.l.p..............	0	12	15	32
+6229	PF06401	Alpha-2-MRAP_C		Alpha-2-macroglobulin RAP, C-terminal domain 	Finn RD	anon	Pfam-B_44514 (release 9.0)	Domain	The alpha-2-macroglobulin receptor-associated protein (RAP)  is a intracellular glycoprotein that binds to the 2-macroglobulin  receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of  all currently known ligands of these receptors [1].   Two different studies have provided conflicted domain boundaries [2,3].	21.80	21.80	22.00	21.90	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.78	0.70	-4.48	11	128	2009-09-10 22:25:31	2003-07-04 12:54:44	6	3	87	4	66	123	1	200.30	44	62.32	CHANGED	-hhcDP+L-KLWpKA+TSGKFScEEL-sLhREFpHHK-KIcEYpsLL-olu+sE..................................EhacNlIsPp-.sshKppsLps+Hs-LK-+hRsIspGaDRLR+loHpGasotpEFpEPRV.-LW-hApsuNFTccEL-Sh+EEL+HFEsKlEKHpHYQcQLElSHpKLKHhtthGDp-Hls+spE+ashLE-+hKEhGYKVKKHhQDLouRIS..th+HNEL	................................hhcD.+LpKLW.pKAcsSGKFSsEELcpLhcEF.HHc-KlcEYpsLL-slu+s-...............................-hpc.NsIs.sp........-....sthKt.pslps+...cs..-L.K-+hRsIppGhDRL.+.+.lopp.Ga.s.stpEFpEPRVh-LWclA.p.su.N.FTpcEL-.Sh.+.....EEL+HFEuKl-KHpHapcpLclu+pKh+....tthGDtE+lscppE+ashLE-+hK..cl.uhKV+KhhpDLps+I...hh+HsEL..................................	0	16	21	44
+6231	PF06403	Lamprin		Lamprin	Moxon SJ	anon	Pfam-B_15493 (release 9.0)	Family	This family consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage. Although not generally homologous to any other protein, soluble lamprins contain a tandemly repeated peptide sequence (GGLGY) which is present in both silkmoth chorion proteins and spider dragline silk. Strong homologies to this repeat sequence are also present in several mammalian and avian elastins. It is thought that these proteins share a structural motif which promotes self-aggregation and fibril formation in proteins through interdigitation of hydrophobic side chains in beta-sheet/beta-turn structures, a motif that has been preserved in recognisable form over several hundred million years of evolution [1].	25.00	25.00	27.60	27.40	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.23	0.71	-4.43	2	8	2009-01-15 18:05:59	2003-07-07 09:25:55	6	1	2	0	1	7	0	122.90	78	98.60	CHANGED	MAAshQALLVlALLHLATATPVlsKppVSThSTGaLGHPVGGLGYGGLGYGGLGhuGLGVAGLGYGGLGYPGAALGGsYTHHAA...................LGGLGYPLGIGAGVVAPHVVpuKlAAPLAPVVAAI	...........................MAAshQALLVlALLHLATATPVlsKppVSThSTGaLGHPV.GGLGYGGLGYG..GLGhuGLGVAGL.GYGGLGYPGAALGGsYTHHAA...................LGGLGYPLGIGAGVVAPHVVpuKlAAPLAPVVAAI.........	0	1	1	1
+6232	PF06404	PSK		Phytosulfokine precursor protein (PSK)	Moxon SJ	anon	Pfam-B_16071 (release 9.0)	Family	This family consists of several plant specific phytosulfokine precursor proteins. Phytosulfokines, are active as either a pentapeptide or a C-terminally truncated tetrapeptide. These compounds were first isolated because of their ability to stimulate cell division in somatic embryo cultures of Asparagus officinalis [1].	25.00	25.00	38.10	34.70	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.46	0.72	-3.21	39	143	2009-01-15 18:05:59	2003-07-07 09:27:33	7	2	32	0	69	132	0	80.10	35	86.39	CHANGED	lLLL.h.s.sh...stAARs....tPs.tspp.tt..........stsppscttt...................................sCc...t.ts-EE.C.LhRRsLs.AHhDYIYTQc+ps	...........................................h.LlL.h...ph....stAAR........Ps.tttp..t....................ttttsptt...................................thh..ttE.............................sC-...t.ts-.EE...C.L.hRRsLs.AHlDYIYTQc+p....	0	8	37	52
+6233	PF06405	RCC_reductase		Red chlorophyll catabolite reductase (RCC reductase)	Moxon SJ	anon	Pfam-B_15577 (release 9.0)	Family	This family consists of several red chlorophyll catabolite reductase (RCC reductase) proteins. Red chlorophyll catabolite (RCC) reductase (RCCR) and pheophorbide (Pheide) a oxygenase (PaO) catalyse the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of Pheide a to a primary fluorescent catabolite (pFCC) [1]. 	24.60	24.60	25.30	25.30	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.55	0.70	-5.44	8	86	2012-09-25 10:41:40	2003-07-07 09:28:14	6	2	40	10	34	91	13	202.40	42	84.35	CHANGED	AHRElMlsLsuplEsRLGup..LLPsslPsDVp.FcN..tuGsApGSLclRSGspuSs.....................................IDFhLtSWlHCclP..tGGAlNITSLslaLNuSTDAPHFlhEhIQuSPTSLlllLDLlPRKDLsLHPDYLccYYEsTtLD.+pRppltcL.PcspPYhSsSLalRulhSPTAlhsoI-ssp..utttplEEIlpsclussAK-VLplWL-pCs..ssscE...ls-sERpthtKRDpllRpKoIElDLsuslP.RhFGt-VAsRVltsIRcAF	.................................t.h..h.t...tpht....hLPsslPsDVp.aps...s..Gs...AtuSLclRsGttuS......................................IDFhltSWlHsclP..tuuulsITol.saLNuSTcAPpFlhEhIQuossSLlllLDL.sRKDLsLpP-YLccYYpsTtLD...ppRppl.cl..PpspPYhSsSLalRSshSPTAlhhplts.tt.......tth-pllp..ltshu.thh.thWlpths..tttt......h.t.tpt..h.tRD..hppt.hEhs.s.phs.phFs.thsspllt.h.t.........................................	0	4	18	25
+6234	PF06406	StbA		StbA protein	Moxon SJ	anon	Pfam-B_12747 (release 9.0)	Family	This family consists of several bacterial StbA plasmid stability proteins [1].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.76	0.70	-5.49	7	732	2012-10-02 23:34:14	2003-07-07 09:29:06	6	2	457	34	70	604	104	269.10	33	89.60	CHANGED	M+lhlDDGSTNIKLAWh.E.cGcl+shlSsNSFK.-Wsssh...sst...pshNY.lDG.c+YoaD.lSssulhTTcspYQYSDVNllAlHHALhpSGLtPQsV-lsVTLPloEaaDpssQsNhtNIpRKKsNlhR.lp..lps.u-sFsI+pVsVhPESlPAuFpsLtt..lsphES.LIlDLGGTTLDluplhGphsGISclasssplGVSllTcuVhpsLsh.ssocsSpahADclIppRpDpsaLpphIpstschstlhpslpct.cpLtp+VhpslupFsshs+.VhlVGGGApLltsAlKpthth.st+hhhsssPQFsLV.uhhth	.......................................................................................................................................l.hDDGopshKl.h..p..ttt.hh...lo.N....S.Fp.t.at......h....t.....tshNY...l.s..s.....pasa..c.h...o.....p.......l.Ts..ph..t..a...QYsp..hNhl..AlpHALh.p..o.Gl.....t.s.p....Vs..lsVT.LPlo...-a.hs...p.ps.Q.s.tp.I..pR...KptNlh...+..lp.........hpt.....up.....s.F...s...I...c...sV...pVh..PE...Sl.PA..s..ap.h.Ltp...........hs.....t....h....-....p.....h...L.....I.......lDlGGTTLD..l..u..h..l....t..u..p..hs..s.....l.o...p..s...h..s..ss...p...lG........V.S.hhsculhps.h........tt....s....s.............h...c...s..S.....p...hh...A.spl.............Ip..p.R......p-....t...........s...a..l..p...p.h.....Ip...s...t.......s.p...hs...........tlh.s.s...I....p....pt.....cpLtp...c.Vhp....s....l......s.....p....F.....p...s.......h.s+....V.......hllGGGA..tl..l.....ts.ul.+pthth....ttp.hhh.tssQhsLs.uhh............................................................................................................................................................	3	21	40	57
+6235	PF06407	BDV_P40		Borna disease virus P40 protein	Moxon SJ	anon	Pfam-B_15995 (release 9.0)	Family	This family consists of several Borna disease virus P40 proteins. Borna disease (BD) is a persistent viral infection of the central nervous system caused by the single-negative-strand, nonsegmented RNA Borna disease virus (BDV). P40 is known to be a nucleoprotein [1].	25.00	25.00	53.20	53.20	18.70	17.70	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.29	0.70	-5.60	3	171	2009-09-10 21:38:57	2003-07-07 09:32:44	6	1	17	2	2	111	0	184.30	67	98.87	CHANGED	MPPKRRLVDDADAMEDQDLYEPPASLPKLPGKFLQYTVGGSDPHPGIGHEKDIRQNAVALLDQSRRDMFHTVTPSLVFLCLLIPGLHAAFVHGGVPRESYLSTPVTRGEQTVVKTAKFYGEKTTQRDLTELEISSIFSHCCSLLIGVVIGSSSKIKAGAEQIKKRFKTMMAALNRPSHGETATLLQMFNPHEAIDWINGQPWVGSFVLSLLTTDFESPGKEFMDQIKLVASYAQMTTYTTIKEYLAECMDATLTIPVVAYEIRDFLEVSAKLKEEHADLFPFLGAIRHPDAIKLAPRSFPNLASAAFYWSKKENPTMAGYRASTIQPGASVKETQLARYRRREISRGEDGAELSGEISAIMKMIGVTGLN	..........................................................................................................................................................................................................................PHEAIDWINuQPWVGSFVLuLLTTDFESPGKEFMDQIKLVAuaAQMTTYTTIKEYLsECMDATLTIPsVAhEI+-FL-sosKLKtEHuDhF.aLGAIRHsDAIKLAPRsFPNLASAAFYWSKK.............................................................................................	0	2	2	2
+6237	PF06409	NPIP		Nuclear pore complex interacting protein (NPIP)	Moxon SJ	anon	Pfam-B_16418 (release 9.0)	Family	This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans [1].	27.00	27.00	27.30	27.40	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.83	0.70	-5.65	5	342	2009-09-13 05:25:39	2003-07-07 09:37:51	6	5	26	0	83	271	0	107.00	34	36.57	CHANGED	VINTLuDHcHsGscFpGs......PWlhIIIsFLRpYKhsIhLCTohLsVSFLKTIFhScNGHDGSTDVQQRAWRSNRpRQcG.................NKIGLKDVITLWRHVETKVRAKI+KhKVTTKIN+HDKINGKRKTAKcH..LRKLSMKECEHAEKERQVSEAEENGKLDMKEIHTYKKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAA..EHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIsDNSLSLKTPP..ECLLpPL....PPSsDDNLKssP	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	69	69	71
+6239	PF06411	HdeA		HdeA/HdeB family	Finn RD, Bateman A	anon	Pfam-B_63431 (release 9.0)	Domain	HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localised in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS [1,2]. This family also contains HdeB [3].	21.90	21.90	21.90	22.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.26	0.72	-4.02	33	942	2009-09-11 09:58:26	2003-07-07 12:09:41	6	2	576	13	43	189	4	94.30	39	85.95	CHANGED	htlshhhhshsssshs.........ssu.ss.spss..........ssppMTCcEFlsLsspthssVshWhhshsp.phKssDhV..Dhppl-sl.sPpllchCKcsPppplh-h	...............................................hht...uhIhhGhlhhssl...........sNAtsA.tAs-..........sspshTCp-Fl....s....LssphhssVshWshs.ss.phKstD.sV..Dlpth-ss.sPtll-hC+psPQsslhc...................	0	8	19	28
+6240	PF06412	TraD		Conjugal transfer protein TraD	Moxon SJ	anon	Pfam-B_11863 (release 9.0)	Family	This family contains bacterial TraD conjugal transfer proteins [1].  Mutations in the TraD gene result in loss of transfer [2].	21.90	21.90	22.30	22.00	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.93	0.72	-4.38	53	460	2009-01-15 18:05:59	2003-07-07 13:19:58	6	4	282	0	117	388	14	64.10	29	63.06	CHANGED	hpsttR+ccTRchIpLGGLVlKAG.......Lst.-+uhlhGALl.hucphcsstt......pphapttGpphFptc	.................p..pR+tcTRchItLGuLVsKAs.......lcsh-+phlhGhLlshuchhptspt.......ttapttGpphhpt................	0	18	57	85
+6241	PF06413	Neugrin		Neugrin	Moxon SJ	anon	Pfam-B_11274 (release 9.0)	Family	This family consists of several mouse and human neugrin proteins. Neugrin and m-neugrin are mainly expressed in neurons in the nervous system, and are thought to play an important role in the process of neuronal differentiation [1].	21.80	21.80	22.60	21.90	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.45	0.70	-4.53	6	219	2012-10-04 14:01:12	2003-07-07 13:23:26	6	6	192	0	152	221	0	144.00	29	49.44	CHANGED	MEssGAP.RpLTW-AhEQIRYL+cEFPEpWoVPRLAEGFsVSTDVIRRVLKSKFlPolEpKLKQDtKV...........hK+hu.s..h..L.usususKhLsuGp...........SlSsuLLhPGcEsuS.tspsHShALKshcpp.ppsssstppps+sKplQsLc-h.shVssssshGc.tp....ssoDspttccthsGsL.SDpcLEELptsEhGc...ss+VVQRGREFFDSNGNFLYRI	...............tth.....sP.+.+Lo.-sh-tIRhL+pp.P-paosspLA-pFplSPEsIR.RILKS.KWp.P.o.......t...-....p.c......c..ptt.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	40	74	118
+6242	PF06414	Zeta_toxin		Zeta toxin	Moxon SJ	anon	Pfam-B_12374 (release 9.0)	Family	This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.02	0.71	-5.22	40	1247	2012-10-05 12:31:09	2003-07-07 13:29:24	7	17	949	8	252	6029	2517	168.70	21	56.57	CHANGED	hsphhss........pt...sp.cpPhullluGQPGAGKopltcthhpph......psshlpl-sD-hRpha................PpYpth.p...t..s.psuphsptt....ushhs-plhspAhcp+hslll-uThpss-hspc.hhcpL+.....c.tGYplplhhlsss.chShttstpRappp...t...............G.Rhlstctactsa.....psh.cslpplcppt..hhsthh.lh...........spss.splYcsphs	..........................................p................ppPh.h.hl.l.uGtsGAGK.oolh....p..h.h.hp.p.h.............tsshl....h...I.........s.....u.....D..p.....h......+.p.....h..............................................................s.p..a.....t......................p.....s..p....h...s..p........................u..s.....p....h..s....p...p....h...l....p...p......h.....h...p...p.....t...h......s....h.l....h..E....s....T.....h....p......s..h....s.......h.........p......p..hhphh+.................................p...tG...Y.p...l.p...l..h.h...l.s..s........p......t...lu.h....p....s.h.Rhtp...............................................................u.+hs.sp..p.thp...hh.....................tt.h..psh.t.th............p.h...lh...........p............t................................................................................................................................................	0	67	159	208
+6243	PF06415	iPGM_N		BPG-independent PGAM N-terminus (iPGM_N)	Moxon SJ	anon	Pfam-B_1338 (release 10.0)	Domain	This family represents the N-terminal region of the 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (or phosphoglyceromutase or BPG-independent PGAM) protein (EC:5.4.2.1). The family is found in conjunction with Pfam:PF01676 (located in the C-terminal region of the protein).	21.20	21.20	21.20	21.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.45	0.70	-5.01	35	2910	2012-10-03 05:58:16	2003-07-07 13:45:27	8	9	2783	9	666	2087	892	216.40	43	44.36	CHANGED	IspuIc-GcFapN.slhpshscscpsssslHlhGLlSsGGVHSHhcHLhALlclAtc+Glc+ValHsFhDGRDVsPpSutsalcclpshhpc.huhG...cIATluGRYY.AMDR.DpRW-RlcpAYcshs...Gcup.phpsulpslpsu...YspshoDEFlhPolIss...t.suslcDsDuVIFaNFRsDRARQlocshsppc.FcsFpRpph...pl.paVshTpY-sslss.slAF	......................IspuIc-GpFh.p.N.tsLhsAlcps+p.....s.s.p..s.lHlhGLlSsGGV.......HSH.cHlhAh.l-lAtcp.G..s..c..+.lYlHAFLDGRDssP+SAtshlcchppthsc......lGhG......clAolsGRYY.AMDR.DpR....W.-RVc..cAYchls..............u.........c.G..p......................p.s.s.o............Alpulpsu...............Y....s......c.......s................s.......DEFVpPsllts....................susl.....pD.GDulIFhNFRsDRA..Rplocshss.........t...........-...F............c.......s............Fp...............Rpph..................sl...pa.l.shTpYs.sslps..hha...............................	0	260	470	585
+6244	PF06416	DUF1076		Protein of unknown function (DUF1076)	Moxon SJ	anon	Pfam-B_2653 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins exclusive to Escherichia coli and Salmonella typhi. The function of this family is unknown.	25.30	25.30	25.50	39.00	22.20	25.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.57	0.71	-4.38	12	614	2009-01-15 18:05:59	2003-07-07 14:06:50	7	1	106	2	3	296	0	106.30	47	63.59	CHANGED	M.pspupspppc...............s....lpsKIspssFsVsspchpCspptlpCPITLshPEcGVFV+NutsSplCoLaDpsAhocLlpcsuhHPLSREPlossMIlu+-cChFDts+tsFsIh	..........................p...pp...............tt.p.L.sKIppCsFsVs.pchpCspphlpCPITLs.PEcGVFl+NSpsSplCoLYDpsAhscLlccshsHPLSREPIosSMIVp+-pChFDsp+tsFllh........	0	0	0	3
+6245	PF06417	DUF1077		Protein of unknown function (DUF1077)	Moxon SJ	anon	Pfam-B_6645 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	25.00	25.00	43.10	38.10	22.10	21.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.61	0.71	-4.80	30	340	2009-01-15 18:05:59	2003-07-07 15:38:58	7	7	291	0	233	300	6	118.90	39	66.13	CHANGED	sppspppppppLthKKAW-lAluPhKslPMNlFMhYMoGNSlpIFPI.MhlhMhlhsPlKulho.ssssFcslcss....................plhhs+llYllhplhshul.........ulaKhpsMGLLPsssSDW.....Luappspph	..............ts...ptpppptLhhKKuW.-lAluPhK.plPMNhFMMYM.oG.NolpIFsI.MM.VhMhhhpPlpulhu.ssssFchhcss............s.............................phhh.+llYlhhplhslul.........ulaKhpuMGLLPTptSDWLua.t...t............................	0	85	134	195
+6246	PF06418	CTP_synth_N		CTP synthase N-terminus	Moxon SJ	anon	Pfam-B_226 (release 10.0)	Family	This family consists of the N-terminal region of the CTP synthase protein (EC:6.3.4.2). This family is found in conjunction with Pfam:PF00117 located in the C-terminal region of the protein. CTP synthase catalyses the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position [1].	22.30	22.30	24.40	23.50	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.89	0.70	-5.31	98	5282	2012-10-05 12:31:09	2003-07-07 15:48:15	9	16	4818	13	1383	3730	3009	264.10	58	50.53	CHANGED	sKaIFVTGGVlSSLGKGlsuAS.lGtLLcsRGhcVohhKlDPYlNVDPGTMSPaQHGEVFVT-DG.............uETDLDLGHYERFlshsho..+psNlToG+.......IYpsVIpKER+G-YLGpTVQVIPHlTsEIKppIp.....ps.sp.............t...sDllIlEIGGTVGDIEShPFlEAlRQhph-h.GpcNshalHlTLVPalpsuGEhKTKPTQHSV+-LRslGIQPDlllsRo-cs.lscsh+cKIALFCsVspcsVIsshDlp.sIYcVPLhLccpGlsphlhccL.......pLs...tps.sh..scW	...........................................TKYIFVTGGVVSSLGKGIsAAS..........LutLLcsRG...Lp............VT.h.K....l....................D....PYINVDP...GTMS......P...a......QHGEVFVT-DG.............AETDLDLGHYERFl.c.hs.....ho..+psNlTTG+..........IYp..........s.V..l.cKERRG.D.YLGs..............T.V..Q.......VI.PHITspIK-+lhcsuct...............................t...sDVlIsE.........I.........GGTV.............GDIESLPFLEAlRQhph-l.........G.+..-sshalHlTLVPYl....t..uuGEh.......KTKPTQH.SVKE..............LRu.....lGIQPDl....LlsR..o..-.c.s....ls.p.sh+pKIAL.FCsVs.t.cuVIpshDsc.oIYclPhhL.ppQGlDphlsc+LpLs....s.psshspW..............................	0	458	871	1151
+6247	PF06419	COG6		Conserved oligomeric complex COG6	Wood V, Studholme D	anon	Pfam-B_10345 (release 8.0)	Domain	COG6 is a component of the conserved oligomeric golgi complex,  which is composed of eight different subunits and is required  for normal golgi morphology and localisation.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-13.04	0.70	-6.39	29	369	2012-10-03 17:31:52	2003-07-07 15:53:51	6	10	276	0	265	379	2	501.50	27	82.22	CHANGED	DuLptLsphshpNThpsRRpLRh-lc+cllcsNsphlc-FtpVscpLcclssslsplspsscphppplssspppTpsllp-sssLhpp.ccplchKpplLpuFps+FhLsptEhthLssstp......sls-cFFplLs+scpI+cDCchLL..us-..spphGLclM-psspplpsAhp+La+ah...Qcca+sL.....sh-ssph...sssl+cAlphLt-RPsLFpssLDpaspuRcpsLs-sFhsALTtsss.............ust.....+PIEhsAHDPlRYlGDMLAWlHSssVsE+EsLcuLFthpscph.cs.p..hp....................ctls-lls+.lpuluRsL+.RlEpllps.....cccslhhYclsNLLpFYpshFs+l.lsssS.....LlpslpsLpchuhppahshhpsplsslpss........ht.sssD..LtPPcaLt-hLppLpslhcs..hpsShss.............sscp............sphphllppsl-PhlphsppsuttLsshpp..............slahlNsLhhhcoslssasasp........c+lp.lpsplsphtspLhphQhphllppoGLsslhshlp.h.........................p.p.htslssh.hhp.psL.tpssppLscFLPoA.LhDhpssL.ppLpSsphspslsccusctFsc.aphlcthlhsstpt.......................hh.+sstclt.slL	..................................................t.Lst.hhtsohpsRRpLRtpl-cc.lt.stphlptFttlt...c......................p................Lcpltpplpthspsspp............hppplp.ss....p....tpTts.lltpsspLptp...ppplph+pplhpsFhpcFp.....LotpEhthLpss...................sl....sppFFpsLt+sppI+pcsc.hLL..ttp.....................ppphGl-l.M-phshh....ptuhp+Lh+Wh..........................ptchcsl...................s.-ssph.................sshlppuhp.hL.pc.R.P.sLa.p.sl-phupsRcpsl.ctFhpALTtuss..........................................st.............+PIEh..pu.HDPlRYlG..........DMLAWlHpshssE+EhlpsLh.....h.tst.p...................................................................................pthppllsc.hpuls+sl+.RlEpll.s................................p....s.lhhaplssLLtFYp.h....hpth..lttps...............L..hpsltphp..s.phahs.hp......phttl.tp.................................ss.D..L.Ps...l.phlt.Lhtlhts...hpsohh....................ttpp.......................................tph..llpthl-Phlphsp.t..u..tt...hts.p...................................................thahlNsh.hhpsslt.aphsp.............phhp.lpttlpt.hppLhp.php.llppsGLt.hhphlp.........................................tshsp...hp..tl..tth..phstaLs.ts.....hh..pl.thl.ssthhpplhppshp.hst.at.l.thlht..p....................................hh.hs..plt.h..............................................................................	1	104	152	220
+6248	PF06420	Mgm101p		Mitochondrial genome maintenance MGM101	Wood V, Studholme DJ	anon	Pfam-B_35151 (release 8.0)	Family	The mgm101 gene was identified as essential for maintenance of the mitochondrial genome in Saccharomyces cerevisiae [1]. Based on its DNA-binding activity, and experimental work with a temperature-sensitive mgm101 mutant, it has been proposed that the mgm101 gene product performs an essential function in the repair of oxidatively damaged mitochondrial DNA [2].	27.00	27.00	36.30	35.80	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.17	0.71	-4.93	27	148	2009-01-15 18:05:59	2003-07-07 15:57:53	7	2	140	0	116	150	1	168.10	61	59.67	CHANGED	lDWspSaaGLuppPFocEsuclLhsPlsspDlEIKPDGllYLPEIKYRRILN+AFGPGGWGLAPRG-olVs.....s+hVoREYALlspGRLVSlARGEQsY.F.sscuIPTAoEGCKSNALMRCCKDLGIASELWDPpFIRpFKpcaspEsasEHl...sTKKKKKlWh+K...ppphsYPaK	.....................................lDWopSaaGLuspPFscEssclLltPlsscDlEI.KPDGllYLPEIKYRRILN+AFGPGGWGLsPRuEolV.o......sKhVTREYALlspGR..........LVSlARGEQ-YF...u.cG...IPT..AoEGCKSNALMRCCKDLGIASELWDPpFIRcFKtpaspEsFVEHV...sTK+K+KlWhRK...-cplpYPaK............................	0	40	69	100
+6249	PF06421	LepA_C		GTP-binding protein LepA C-terminus	Moxon SJ	anon	Pfam-B_425 (release 10.0)	Family	This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins [1].	22.00	22.00	23.00	23.70	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.35	0.72	-4.14	45	4879	2009-01-15 18:05:59	2003-07-07 15:58:45	7	24	4651	11	1211	3357	2420	106.40	65	17.86	CHANGED	lNG-hVDALShIVH+spAhp+GRplspKLK-lIPRQ.F-lsIQAuIGu..KIIARETIKAlRKs....VlAKCYGGDloRK+KLLEKQK-GKKRMKplGsVElPQEAFlulL+h	................lNG-pVDALShIVH+DpA.pRG+tls-KLK-LIPRQ.F-lsIQAAIGs...+IIARp.....TlKAlRKs....VL.....A.....K....CY..GGD.l.SRK+KLLEKQKcGKK..R..M..K..p..l.Gs...VElPQEAFlAlL+.......................	0	417	786	1029
+6250	PF06422	PDR_CDR		CDR ABC transporter	Gauthier C, Studholme DJ	anon	Pfam-B_1005 (release 8.0)	Family	Corresponds to a region of the PDR/CDR subgroup of ABC transporters comprising extracellular loop 3, transmembrane segment 6 and linker region.	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.33	0.72	-4.36	167	1227	2012-10-03 10:13:34	2003-07-07 15:59:49	7	44	184	0	900	1245	0	97.70	26	7.84	CHANGED	shlPs.Gs..sYt.shs.ssppsCu.ssGuhsGps.....hVsG-s.YlptuasYphuHhWR.....NaGIllAFhlhFhslhllssEhhpsspupG-sLlFpRuph.pt......................tttt.....sDtE	..................................hlPt..G..s...sYt...shs.....tppsCs..hsGuhs...Gp..s......hVsGc.s.YlptsasY............phuH..hWR......................NaGIlhuFhlh.Fhhhh.lls.s..Ehh....p...h....tts...t.u.p.h.lla.+sph.th....................ptt.............................	0	239	480	779
+6251	PF06423	GWT1		GWT1	Wood V, Studholme DJ	anon	Pfam-B_15982 (release 8.0)	Family	Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast [1-2].	29.60	29.60	29.60	29.60	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.07	42	299	2009-01-15 18:05:59	2003-07-07 16:01:32	7	11	251	0	222	304	3	145.70	30	28.81	CHANGED	tNREGlhShh.GYlAIFLhGpsh.Ghhllspphsh.......................................ttthhphlhpLhhhshlhhhlhhls.......thshslSRRlANhsYVlWVsuhNsthLhhasll-phhhsshh.....................................sspllpAhNpNGLslFLlANlLT..GhVN	.........................................................tNREGlhShh.GYluIaLhGh...sh.Ghhlhspptp...........................................................................................................pphhphh..hpLhh.huhhhhhhhhlsp........shs.slSRRhANhsYll.WlhAhshh...hLhh...hh.lh-t...l...hh.sh.................................................................................sstllpAhNpNsLhhFLlANllT..GlVN.................................	0	72	114	179
+6252	PF06424	PRP1_N		PRP1 splicing factor, N-terminal	Wood V, Studholme DJ	anon	Pfam-B_6467 (release 8.0)	Domain	This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1 [1]. It is involved in    mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.	20.90	20.90	20.90	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.50	0.71	-3.83	33	327	2009-01-15 18:05:59	2003-07-07 16:04:43	7	42	271	0	240	327	4	141.10	45	16.43	CHANGED	sPsGYVuGlGRGATGFoTRuDhGsu+t.........................................pppp-cDsschs-............stst.uLFupst.h..Dc-DcEADcIYppIDc+MccRR+pc+Ep+pcp-hpchctpp.......PplppQFuDLKRsLusVo---WtsIPEsGDhTtK	..................................AP.sYVsGlGRGATGFTTRSDl..GPAR-uss..t.t...............................................tttppp.ppp-c-.-cchp-...............s.st..uLF.uss...Y...DcDD-EADtIYp.tlDc+..MDcRRKc+REtRp+pEhEcactpp..........PKIppQFuDLK.............RpLusVo--EWtsIPElGDhpt+............................	0	85	135	200
+6254	PF06426	SATase_N		Serine acetyltransferase, N-terminal 	Wilbrey A, Studholme DJ	anon	Pfam-B_1192 (release 8.0)	Domain	The N-terminal domain of serine acetyltransferase has a sequence that is conserved in plants [2] and bacteria [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.29	0.72	-3.78	111	1759	2009-01-15 18:05:59	2003-07-07 16:08:33	9	11	1568	37	424	1080	487	92.10	42	34.01	CHANGED	lWppl+pEAcpssppEPlLuualauoILpHsolcsALuapLusKLuss.phs..s.hLp-lhpcAhts.cP............plspusp..sDlhAlh-RDPACpp.ahpPlLaaKGFpAlQu	...........................................lWppI+tEActhsppEPhLuuFhauol.LpHpsLtsALuahLAs+....Lsss......h...s...u.......htlc-lhcc.shts...cP.................phhtsst..sDIpAVhpRDPAscp.aspPLLYhKGFHAlQs................................	0	116	251	340
+6255	PF06427	UDP-g_GGTase		UDP-glucose:Glycoprotein Glucosyltransferase	Studholme D, Wood V	anon	Pfam-B_4648 (release 8.0)	Family	The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase.	21.20	21.20	22.60	22.50	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.20	0.70	-5.03	20	379	2009-01-15 18:05:59	2003-07-07 16:09:48	6	11	262	0	258	355	5	194.50	35	14.04	CHANGED	SDhhhphsuhh...ush.ppcs.....Rhsh.phls.spposlpl..s.tppcs........shhclsAllDPlo+puQKlssllphLschl..slsl+lahNPps....phs-lPlKsFYRaVlp.sp.pF.sssGthss.PtAhFsslPsspLLThsl-sP-uWlVpshcu..paDLDNIhLpclsss..........................VsApYcLEplLlEGaspDhssssPP.RGLQLpLs..opssshhs..........DTIVMAN	....................................................................t...........Rhph.phhp...spao.slpl..s.....ps.cs.............hhcllAllDPlocp.AQ+hsslLh.lLpplh..sspl................+...lahN.sps.......cls.-..hP..l.K.p........FYRaVL-.sp..pF.ss.s...s....phs..t....PhApFh.slPpssLLTlshpsPpuWhVp.....shco..saDL.DNIhLpplpss............................VpA.YELEalLlEGHshD.......h....ss.s...p......P....P.RGLQhhLG...Tp..pp.Phhs..............DTIVMAN..............................	0	86	135	206
+6256	PF06428	Sec2p		GDP/GTP exchange factor Sec2p	Wood V, Studholme D	anon	Pfam-B_10665 (release 8.0)	Family	In Saccharomyces cerevisiae,  Sec2p is a GDP/GTP exchange factor for Sec4p, which is required for vesicular transport at the post-Golgi stage of yeast secretion [1].	22.30	22.30	22.60	22.90	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.33	0.72	-4.16	20	379	2009-01-15 18:05:59	2003-07-07 16:11:44	6	8	194	24	259	345	1	101.60	31	20.52	CHANGED	scltccccp+tpsEpppspLppElE-LTASLF-EANcMV....usA+tEppshchKNcpLccQL+Ep-sll-sLQtQLpsLKplhhs.....................hpspp.....spppptsst	........................p.pLp.ccppppchpph+pplppELE-LTAuLF.............EEApcMV....tpAp............h+p...sp.......hE+pLcEscscl-sLQtplttLKplh.p.....................................pt...........................................................	0	71	121	196
+6257	PF06429	Flg_bbr_C	DUF1078;	Flagellar basal body rod FlgEFG protein C-terminal	Moxon SJ	anon	Pfam-B_807 (release 10.0)	Domain	This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which Pfam:PF00460 is often present at the extreme N terminus.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.41	0.72	-4.06	463	11734	2009-01-15 18:05:59	2003-07-07 16:15:12	8	19	2105	7	2780	7802	1705	79.40	24	23.35	CHANGED	ssLp...phussL.a...ttss.............Gs..s...hs.s........ssss..............p...l..tpGhL..EsSNVsslcEhsshIsspRsYEhssKhlpsuDphhpp.sspl	.........................................................................................t...........h........................t..........................s.ss.....................tl....tpGhl....E....tSN.V.sl.spEhsshIpsQRuYpu.Ns+sls.o.s.cphhpphlp.......................	0	883	1749	2237
+6258	PF06430	L_lactis_RepB_C		Lactococcus lactis RepB C-terminus	Moxon SJ	anon	Pfam-B_717 (release 10.0)	Family	This family consists of the C-terminal region of RepB proteins from Lactococcus lactis (See Pfam:PF01051).	20.30	20.30	22.60	47.70	19.90	18.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.65	0.71	-4.06	13	139	2009-01-15 18:05:59	2003-07-07 16:23:41	7	3	51	0	9	140	2	119.00	64	33.07	CHANGED	KRhADDNSYKL-..DcsY.EDKspKEpsEcpLhhcAMcS.YTKLLhEpFLLSshDhTDsulMAGLQKNVYPLYDELK-LRGLNGVK-HLSYVuSKQEsYSKRNlAKYLKKAIEQYLPTVKRQDL	...............KRhADDNSYKL-..DpsY.csKtpKpcsEctLhh.pAMcS+YT+LLhEshLLSsh-hpDTslMuGLQcpVYPLYDELK-LRGLNGVKDHLSYVuSKpEsY..S..K+N.lAKYLKKAIEQYLPTVKRQDL.......	0	1	1	7
+6259	PF06431	Polyoma_lg_T_C		Polyomavirus large T antigen C-terminus	Moxon SJ	anon	Pfam-B_214 (release 10.0)	Family	\N	22.40	22.40	23.00	24.00	21.10	22.30	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.37	0.70	-5.82	3	1776	2012-10-05 12:31:09	2003-07-07 16:44:43	6	5	48	37	0	501	0	116.30	75	64.60	CHANGED	TKQVSWKLVTEYAlETKCEDVFLLLGMYLEFQYNsEpCKKCpKKDQPsHFKYHEKHYANAtIFADSKNQKSICQQAVDTVLAKKRVDSLHMTREEMLTERFNaLLDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIYDFLKCIVaNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKALNVNLPLERLNFELGVAIDQFMVVFEDVKGTGAESRDLPSGHGINNLDsLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVRQIDFRPKsYLRKSLpsSEFLLEKRILQSGMTLLLLLIWFRPVADFAsuIQSRIVEWKERLDpEISMYTFS+MKaNVuMG+sILDasREEDSEsEDSGHGSSTESQSQCsSQVS..-sSGsDoQSQsS......aHlCKGFQCFc+P	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSTESQSQC.SQVS..EASGADTQEHCT....................YHICKGFQCFKKP.....................................	0	0	0	0
+6260	PF06432	GPI2		Phosphatidylinositol N-acetylglucosaminyltransferase	Wood V, Studholme DJ	anon	Pfam-B_33496 (release 8.0)	Family	Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This  step involves products of three or four genes in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.	23.90	23.90	32.70	24.00	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.95	0.70	-5.06	37	324	2009-01-15 18:05:59	2003-07-07 17:06:08	6	9	277	0	237	310	4	271.90	29	80.42	CHANGED	W+KlLY..hcQsYPDNYo..D.poFLppLppNssltpa.........sahpllh-shslsQplssVslhhllFshlhppp..............................................lss.slhhhssshshhualh...hthht.t.s...................................................................................................................hhpsh+ohlllhhhlhhLSPlL+oLTcohSoDoIauloshlhlhalhhaDY..u.............htsh.stt...................htsslShNhulhuullLASRLsoshpVFshllhulplF...sLhPhhppp.l+ths.hhphhhshhhshhshhsh.............hhhshhhhlhahhhllhlshlsPh.......ahltlQpa.............KspIpGPWD	..............................................................................................WcKlLa...+Q.sa..PDNYs..D.tsFLcpLpcNhphp.Y.........................sah.tllhcssslsQplsslslahhha.hhhhptt........................................................................................l.sPh..lhhhsshh.shlGalh...hthh..t.t......................................................................................................................................................h.phhtsl+.osl...lh..hhhhhsLS..PlL...+oLTcohSoDoIaAho.hhhhlhp....lh.haDYu...........................................ht...st............................sslShNsAl.huossLASRLs..........oshcsFshhhhu.lplF...sLhPhhppp.l+...th....s....t.ht.hh..lshhh.sh.hshhsl....................h.hshhhhhh.hh..h..h..h..h..hh...hh..sPh.......hhlt.hQpa.............KppltGPWD...................................	0	79	127	193
+6261	PF06433	Me-amine-dh_H	Me-amine-deh_H;	Methylamine dehydrogenase heavy chain (MADH)	Finn RD	anon	Pfam-B_20644 (release 9.0)	Domain	Methylamine dehydrogenase (EC:1.4.99.3) a periplasmic quinoprotein found in several methyltrophic bacteria. Induced when grown on methylamine as a carbon source MADH catalyses the oxidative deamination of amines to there corresponding aldehydes.  MADH is a hetero- tetramer, comprised of two heavy chains (H) and two light chains (L).  The H-chain forms a beta-propeller like structure [1].	19.50	19.50	19.50	19.50	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.11	0.70	-5.81	5	83	2012-10-05 17:30:42	2003-07-08 09:40:06	6	2	76	105	32	104	19	332.60	33	86.65	CHANGED	DARRVYVhDPuHFAAlTQhYsIDGcouRlLGMTDGGFLPNPVVASDGSFFApASTVYSRIARGKRTDYVEVlDPpTapPIADIELP-uPRFLVGTYsWMsuLTPDNKsLLFYQFSPuPAVGVVDLEGKuFcRMlDVPDCYHIFPouNsoFFMHCRDGSLt+Vuaus-GsoK.hKsTEVFHsEDEYLINHPAYSs+SGRLVWPTYTGKIFQADLSupcAcFLsPIEAFTEAEKADsWRPGGWQQVAYHRApDRIYLLuDQR-cW+HKsASRFVFVlDAcTGKRLsKIELGHEIDSIuVSQDAKPhLYALSsGsKTLaIFDAsTGKELuSVDQLGRGPQlIhTuD	............................................tt....hhl.D....t.h....s.+.laV...hD..uDs....t+..l..LG.lsuuasss.hs.l.o.s..Dt+phYlAsTaasRss+GpRTDllphaDssTLphsuEI.lPst.+t...s.s.s.p.tsh.uhosDG+hhaVhNhTPusSVoVlDhsu+KV.l.p.pl-sPGCshl..Y..P..s..u..s..s.s.Fo.uLCtDGshhsVsLDssGK.s.s...pp.p..o..s..hF...s.sc.D.s.lFppssh...st..hsuphhF.soYsGpVhsschous.s...s.....p....h....t..t.shp......l........h.s-u.c.+............t...........t......sWRPGGaQ.hAlpt.....spp+hY.V.L.M.H.pG.s.p...toHKDsGTpVWVhDhpo+cRlsRhsL.t.p...t....ss...SlsV..op.D-.cPllaulss.ss........uslhVhDAt.o..G.c.h+shc.tlGps........hh..................................	0	7	17	24
+6262	PF06434	Aconitase_2_N		Aconitate hydratase 2 N-terminus	Moxon SJ	anon	Pfam-B_2605 (release 10.0)	Family	This family represents the N-terminal region of several bacterial Aconitate hydratase 2 proteins and is found in conjunction with Pfam:PF00330.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.27	0.71	-4.91	94	1563	2012-10-01 19:37:30	2003-07-08 12:39:19	8	6	1505	2	323	1212	908	208.10	67	25.23	CHANGED	loVFKV.sGETNTDDLSPAs-AaSRPDIPLHAhAMLcschss............slppItcLK.pKGhP....lAYVGDVVGTGSSRKSAsNSV.LWahGcDIPaVPNKRsGGlllGGp.IAPIFFNTsEDSGAL........................PIE.sDVsplphGD..VIsIh..PacGclpc.....tsG...................................................................................................................c...llupFpLpPsslhDEVRAGGRIPLIIGRuLTsKARpsLGL...ssSslFtpP......ppPss.su+Ga	...................................................................................lTVFKV.sGETNTDDLSPAP.DAWS..RPDIPLHALAMLKNsR-GItP-...sG.hGPl+pIEtLp.pKGaP....lAYV.GDVVGTGSSRK.SATNSV.LWFhG-DI.PaVPNKRuG..Gl..sLGGK.IAPIFFNTMEDAG..A..L........................PI..E...l..D..V.Ss.LsMGD..VI..D..lY..PYcGclpp.....tsG.........................................................................................................................E....llAsFcLKo-VLl.DEV.RAGGRIPLIIGRGLTsKAREuLGL...st..S..-lFRpscs.sA-.Ss+Ga...........................................................	1	74	178	263
+6263	PF06435	DUF1079		Repeat of unknown function (DUF1079)	Moxon SJ	anon	Pfam-B_1911 (release 10.0)	Repeat	This family consists of several repeats of 31 residues in length and seems to be exclusive to Moraxella catarrhalis UspA proteins. The UspA1 and UspA2 proteins of Moraxella catarrhalis are structurally related and are exposed on the bacterial cell surface where can function adhesins [1]. This family is commonly found with the Pfam:PF03895 family.	21.00	21.00	23.40	21.80	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.45	0.72	-3.94	4	220	2009-01-15 18:05:59	2003-07-08 12:51:55	6	19	12	4	9	218	0	29.60	52	16.20	CHANGED	lushhc.tcsascpQoEsIcuLsKASutNTs	lssh.ELtpQ.sp+po-.IcsLsKASutNTp....	0	0	9	9
+6264	PF06436	Pneumovirus_M2		Pneumovirus matrix protein 2 (M2)	Moxon SJ	anon	Pfam-B_2318 (release 10.0)	Family	This family consists of several Pneumovirus matrix glycoprotein M2 sequences. This family functions as a transcription processivity factor that is essential for virus replication [1].	25.00	25.00	134.20	134.00	22.00	17.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.90	0.71	-5.00	4	75	2009-01-15 18:05:59	2003-07-08 13:06:16	6	2	17	1	0	72	0	156.70	58	82.92	CHANGED	pWPsHsLLVRpNaMLNplL+shDRo.DsLS.ISGAuc.DRTp-asLGsssVlpsYIsu.sNITKpSAChuh.pllppLppsDlKphRDpcVssS.+ltlaNhVlSYI-.s.KNstphIp.LKRLPt-hLKKhhKhhI-lpsulphpNssssslpDttNs	pWPs+sLLlRpNaMLNplL+shD+S.DsLS.ISGAuc.DRTp-asLGsssVlpuYIss.sNITKpSAChuhppllppLppsDl+phRDNc.ssS.+VtlaNhVlSYlE.s.KsstphIp.LKRLPt-hLKKhhK.hlDlptuls.pNsppsslpDos..s...	1	0	0	0
+6265	PF06437	ISN1		IMP-specific 5'-nucleotidase	Studholme D, Wood V	anon	Pfam-B_43910 (release 8.0)	Family	The Saccharomyces cerevisiae ISN1 (YOR155c) gene encodes an IMP-specific 5'-nucleotidase, which catalyses degradation of IMP to inosine as part of the purine salvage pathway.	25.00	25.00	84.50	84.40	23.60	19.20	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.37	0.70	-5.76	18	157	2009-01-15 18:05:59	2003-07-08 13:32:53	6	4	137	0	127	156	1	373.80	47	89.08	CHANGED	MoSRYRVEY......tLKsHR+DpFI-W.............IKGLLAV.PFVLHut..t...................t....s.tthspcs+cRYuEIFpDVEpLIsc+Ithspp.sp.................spSRL+hLVPSIGsFFT.LPLp-AFhhpDc+RsISpRRhVuPSFNDlRhILNTAQlhuLsctt....................pLcLlTFDGDVTLY-DGtSLssssPVIsRLl.................cLLppslplGIVTAAGYsc...Ap+YhpRLpGLLcAlpsss.sLsssQKpNLlVMGGESNYLF+assss...stsLp.lscccWlLPcMpsWsppDIsplLDhAEpsLpchhppLsLP....ssIlRK-RAVGIlP..........pssh+lhR.EpLEEhVLslQppLEp...........................stsu..pcl.FCAFNGGsDVWVDIGDKuLGVpsLQ+aa...........t..ssIpsocTLHVGDQFhSsG.ANDFKARLuusTsWIAuPpETVplL	........................................................................p.....................pst..................................................lcuLLAs.PFVLau..t..........................p...hstcscppYs-IhcDlEthIp-+.Ithppt.st...................................t.S+LphLVPolG.sFFT.LPLpcAFhhpDppRhISpRRaVsPSFNDlRhILNoAQlhulsc.t.............................tLcLlTFDGDVTLY-DGtsLp..sssPlIs+ll.................cLLcpshplGIVTAAGYsp...As+Y.pRL+GLL-Alpss....sLsspQKpsLhlMGGESNYLFcasts...........htLp.......lsc...pcW.....h......hs...cMtsW.....s.c.....p..DIpplLDhAEpsLpphhppLsLP....ssIlRKcRAVGIlP...............................ssh+h.R.EpLEEhVLslQppLEh..............................................st.su..pclPFCAFNGGs...........DVaVDIGsKuhGVpshQpaa..............ssIpsscTLHVGDQFhssG.uNDFKAR..............susThWIAsPtETVplL.........................	0	35	73	108
+6266	PF06438	HasA		Heme-binding protein A (HasA)	Finn RD	anon	Pfam-B_27216 (release 9.0)	Domain	Free iron is limited in vertebrate hosts, thus an alternative to siderophores has been developed by pathogenic bacteria to access host iron bound in protein complexes.  HasA is a secreted hemophore that has the ability to obtain iron from hemoglobin. Once bound to HasA, the heme is shuttled to the receptor HasR, which releases the heme into the bacterium [1].	26.30	26.30	27.30	32.80	25.50	26.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.36	0.71	-4.92	7	96	2009-01-15 18:05:59	2003-07-08 15:17:58	7	2	67	21	10	66	4	204.00	39	99.08	CHANGED	MohSlsYsusauuaolusYLs-WuusFGDlsHtsups..sssNTGGFssGs..hsGoQYAlpSosss.tAFIAsGs....L+Yoh..sPu........HTLaGpLDoluhGcsL...uGGsu.us..asLss.-VoFssLsLsu.hupG+s......G.sVHpVlYGLMpGsouuLtsslsslLt..shGlSlNsTFDpluAAsss.s...husss.VshVGVQ-sspDhhLAA	..........................MosoIpY.sopausaoloSYLpcWusp....FGD..lsptsups...........ps....pGuFssus..........FsG..o..QYAl..s...Sop.......u..s.s..tu.h.......I....ApGD.......L+Yoh....Pp..............HThaG.p..l.DoLphGcsL...........s.su.su.sG....hpL-phclsFs.sLDlsu-h-su+shhp.........shpG.shHKulYGLM+GNssP.hL-hl........c....................ApGIslsTshKDluIASQhtsss..huDA..P.hlDTVGVh-.s.p-hLLAA.........................	0	1	3	5
+6267	PF06439	DUF1080		Domain of Unknown Function (DUF1080)	Yeats C, Eberhardt R	anon	ADDA_10682	Family	This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	26.30	26.30	26.30	26.40	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.51	0.71	-4.40	189	1312	2012-10-02 19:29:29	2003-07-08 16:01:14	6	119	323	12	583	1442	1367	194.00	21	46.62	CHANGED	sh...tsLF..s........Gc..sL.sG....Wp...sh..................................................................h.D.G.........................hlh.........................ssptsshlhoc...p.pas.sFpLcl-a.+.................ss..ss..............NSGlhh+sp........................................h..uh.EhQlhs......sttt..........................ptsGulY............................................................st...spsshssscWNphcI.hspusp............lp.h.hlNGhhlhchsphpst.t..............................ppGhIuLQ.sHu..........s............lp..FRNIpl+	.................................................................................................................................................hh.LF.s.Gp..sh.su....Wp...thttt...............................................................................................................lp-.G.........................hlh.........................tssssu..lh...o.....p.....c...pa.s.....sF.pLcl-a.+h...............st..su.............................NS.G....lhhpsp......................................h..uh.EhQlhs.....sttt.........................ttsGu.lY.................................................................st..spsshs...sG.cWNp....hcI..hs.p.usp..............lp..h.hl..N.G..h..hl..hchsphss.h................................................tpGhIuLQ..sHu............s.............tlt...FRNlplc.......................................	0	323	505	562
+6268	PF06440	DNA_pol3_theta		DNA polymerase III, theta subunit	Finn RD	anon	Pfam-B_27631 (release 9.0)	Domain	DNA polymerase III (EC 2.7.7.7) is comprised of three tightly associated subunits, alpha, epsilon and theta. This family contains the theta subunit.   The structure of the theta subunit shows that the N-terminal two thirds is comprised of three helices while the C-terminal third is disordered [1].   The function of the theta subunit is poorly understood, but the interaction of the theta subunit with the epsilon subunit is thought to enhance the 3' to 5'  exonucleolytic proofreading activity of epsilon [2].	32.30	32.30	32.40	36.10	30.60	32.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.41	0.72	-4.39	11	627	2009-09-13 11:27:20	2003-07-08 16:11:56	6	1	540	7	57	179	3	74.00	76	95.14	CHANGED	M..saNLApLScE-hDKlNVDLAASGVAaKERhNMPVlsE.VEREQPEHLRpYFRcRLtaYRptSppLs+hs.....-P+h	.......pNLAcL-QsEMDKVNVDLAAAGVA...FKERYNMPVIAE.sVEREQPEHLRuWFRERLIAHRLASVsLSRLPYEPK...........	0	2	12	37
+6269	PF06441	EHN		Epoxide hydrolase N terminus	Yeats C	anon	ADDA_11591	Family	This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds [1]. This family is often found in conjunction with Pfam:PF00561.	22.50	22.50	22.80	22.80	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.64	0.71	-4.15	143	1051	2012-10-03 11:45:05	2003-07-08 17:03:29	7	12	454	6	597	1123	575	110.20	35	27.04	CHANGED	pPF....plplscspLs-L+pRLptoRa...Pspts.sss............hp.hGsshshlccLscYW............................ts.sa..D................WRptEscLN...paPpFpTpI........-..................GlcIHFlHh+S......pps.sAl.PLllsHGWPGShhEFhclI	...................................pPFclplsppplsDL+pRLptoRh.....sst.....sss................ap.hG.hshshlcclscYW...................................ps..sY..D..................WRptE..ttLN...p.aPpFpTpI.......-..........................GlsIHFlHh+o.............................tps.sAl..P...L.l.lsHGW......PG..ShhEFhclI................................................................................	0	184	337	490
+6270	PF06442	DHFR_2	DHFR;	R67 dihydrofolate reductase	Finn RD	anon	Pfam-B_27527 (release 9.0)	Family	R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial  drug trimethoprim.  The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase [1].	25.00	25.00	27.20	92.50	22.80	22.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.64	0.72	-4.35	3	33	2009-01-15 18:05:59	2003-07-08 17:07:36	6	1	13	8	0	18	0	78.00	81	96.15	CHANGED	MscSSNEVSsPVAGpFAFPSNATFGLGDRVRKKSGAAWQGQIVGWYCTsLTPEGYAVESESHPGSVQIYPVAALERVA	....................M-pusNEVSsPVAGpFAFPSNATFGhGDRVRKKSGAAWQGQIVGWYCTpLTPEGYAVESEuHPGSVQIYPVAALERls..	0	0	0	0
+6271	PF06443	SEF14_adhesin		SEF14-like adhesin 	Finn RD	anon	Pfam-B_36358 (release 9.0)	Family	Family of enterotoxigenic bacterial adhesins. 	21.90	21.90	22.10	22.70	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.03	0.71	-4.60	2	40	2009-01-15 18:05:59	2003-07-08 17:32:33	6	1	19	7	0	37	0	129.40	63	98.20	CHANGED	+St.ulhlhALhsCGuApAAshVGshAsVpAslshuAQNThsAsWoQDsuhoGsuVsAhQKlGTLsIphTGsHsuV.luGcssu.SGGlhTlPFhsstGQslFRGRhput.hps.ssshlst.u.GW+lsuoQ-shNlslpsF.stsslPAGpaTATFYlQQYQs	................................................ssTluAQNTTSANWSQDPGFTGPAVAAGQKVGTLSIT.ATGPHNSVSIAGK.GASVSGGVATVPFVDGQGQPVFR.GRIQGANIN..DQANTGIDGLA.GWRVASSQEThNlsl..............................	0	0	0	0
+6272	PF06444	NADH_dehy_S2_C		NADH dehydrogenase subunit 2 C-terminus	Moxon SJ	anon	Pfam-B_1662 (release 10.0)	Family	This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with Pfam:PF00361.	21.50	21.50	21.60	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.06	0.72	-3.66	136	25512	2009-09-10 16:36:32	2003-07-08 17:37:30	6	3	12030	0	41	25653	0	54.00	43	16.22	CHANGED	LaFYLRlsYshsLThsPsssssth.pW..Rhps.pp....shhls.hhhsholhhL.PlsPhlh.s	.....LFFYLRLuYssTlTlsPs.ossphp.pW....+hpp..sp.......shh.lu...hh...sshShhLL.Pl.o.Phlh.....................................	0	5	8	18
+6273	PF06445	GyrI-like	AraC_E_bind;	GyrI-like small molecule binding domain	Finn RD, Anantharaman V	anon	Pfam-B_36124 (release 9.0)	Domain	This family contains the small molecule binding domain of a number of different bacterial transcription activators [1].\	This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding [3].  The GyrI superfamily includes a family of secreted forms that is  found only in animals and the bacterial pathogen Leptospira [3]. 	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.75	0.71	-4.19	88	6066	2012-10-02 11:08:51	2003-07-08 18:33:54	10	24	2274	26	1074	4279	124	155.40	16	64.70	CHANGED	hphclhphsshplhulcppsshsp............lsphh.pplhthttppth.................tssshhulhhspst......spspphchthshthst........................ptstshphhplsuu.paAshpap.Gsh......ssltpshpplastalspssh....thtsssshEhYhss.........ttpphhs.-lhlPlp	......................................................................................................................................phplhph.s.php.lh...u....h.....p.t..p...h.s.p.t...............lsphh..p..ph..ht.hhhppth......................ssth.hul..h.h.s.ps.........t..t..sp....p...h..p.h..p..h..s.h.ss.sp........................................psspshp..h.pl.s..u.G...pYA.sh.p.hp...Gsh...........psht.c..shtt.lap..alsp.p.sh......................phtss.s...p....h....E..h..Y..hs..s.t..........pstphph..-lalPl..................................................................	0	387	718	907
+6274	PF06446	Hepcidin		Hepcidin	Finn RD	anon	Pfam-B_41732 (release 9.0)	Domain	Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin [1].	21.90	21.90	26.30	25.80	19.90	19.70	hmmbuild  --amino -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.71	0.72	-3.56	20	197	2009-01-15 18:05:59	2003-07-09 10:43:59	7	1	91	5	26	181	0	55.70	42	64.69	CHANGED	chEEhtspDsssAttpptss-shth...hRpKRps.phshCtFCCsCC..+hpG..CGhCC+F	.....................pLEEsh.upDs.ssA.stpEhsh-Shhhs.t.Rp..KR.p......t..hC+.FCCsCC..phps..CGhCC+F.........	0	1	3	13
+6276	PF06448	DUF1081		Domain of Unknown Function (DUF1081)	Yeats C	anon	ADDA_12201	Family	This region is found in Apolipophorin proteins.	25.00	25.00	25.00	25.20	21.90	23.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.51	0.71	-4.21	22	170	2009-01-15 18:05:59	2003-07-09 11:20:46	6	14	99	0	78	163	0	116.10	27	3.77	CHANGED	sschppp...sCh.shlc.hhGlphChsh..shssl.ps......puh..........PLusPshhcl.lcts-.phctYphpushctpp....ss.....cpl+htlcs.Gupss+-upsslpas+cpcsh............................louclptsshsuc	.............+.shssCp..shhs....GLphCssh..sas..sssss.................sus.........shaPLoGssphpl.Lc.ss.phcpYshphsachpc....ts........................cshchshps..G.........sp..pcsshshp..hspppts.............................hp.pl....h...t....................................................................	0	21	28	55
+6277	PF06449	DUF1082		Mitochondrial domain of unknown function (DUF1082)	Moxon SJ	anon	Pfam-B_2173 (release 10.0)	Family	This family consists of the C-terminal region of several plant mitochondria specific proteins. The function of this family is unknown. This family is found in conjunction with Pfam:PF02326.	25.00	25.00	44.80	43.80	23.00	20.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.51	0.72	-4.08	5	109	2009-01-15 18:05:59	2003-07-09 11:38:49	6	3	77	0	7	82	0	49.70	77	30.50	CHANGED	DLLGK+RKIThISCFGEISGSRGMERNILYLISKSSYST.ss..oGWtIT...C+N	DLLGKR.R.KITLISCFGEISGSRGMERNIhYLISKSSYST..........sGhtITC+N........	0	1	4	6
+6278	PF06450	NhaB		Bacterial Na+/H+ antiporter B (NhaB)	Moxon SJ	anon	Pfam-B_5993 (release 10.0)	Family	This family consists of several bacterial Na+/H+ antiporter B (NhaB) proteins. The exact function of this family is unknown [1,2].	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	515	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-12.95	0.70	-5.88	4	838	2012-10-02 15:12:49	2003-07-09 11:48:14	7	2	810	0	104	725	503	497.90	75	99.01	CHANGED	M.hohupAFh+NFLGpSP-WYKlAIlsFLIINPIlFFhISPFVAGWLLVAEFIFTLAMALKCYPLQPGGLLAIEAlhIGMTSAppV+cElhANlEVLLLLlFMVAGIYFMKQLLLFlFTKlLlpIRSKhLLSLuFChAAAFLSAFLDALTVlAVlISVAVGFYuIYHKVASGpsh.tDpDhosDs+IpE....hp+s.LEpFRuFLRSLhMHAGVGTALGGVhTMVGEPQNLIIAcQAsWpFGEFhlRMSPVTlPVFICGLLTChLVEKh+lFGYGtpLPDpV+cILsDaDcppccpRTpQDKhKLhVQAlIuVWLIsuLALHLAuVGLIGLSVIILATSFTGVTDEHulGKAFpEuLPFTALLsVFFSVVAVIIDQpLFuPlIpaVLssE-p.TQLuLFYlhNGLLS.lSDNVFVGTVYINEsKAALhsGhIThcQF-LLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVaMALPYTlVLoIVGLhuIpFh.LtssTtaFhshGhIhs	......................................MclShGpAhh+NFLGpSPDWYKLAlllFLIlNPllF.hl.uPFlAGWLLVAEFIFTLAMALKCYPL.PGGLLAIEAVhIGMTSs....cH.................V+EElAANLEVLLLLMFMVAGIYFMKQLLLFIFT+LLLuIRSKhlLSLuFClAAAFLSAFLDALTVVAVVISVAVGFYGIYH+VASu+s....-.-..sDhpDDS.+I..-.c....c.h+ssLEQFRuFLRS...LMMHAGVGTALGGVMTMVGEPQNLIIAK.sAG......Wc..FG-F..FL.RMu.P.VT.V..P..V..L.I..C..G..L.L.TChLVEK..h..R..hF.G..YGp.pL..PE..+.V.R.cV..Lp.pFDcpu.R+.p.R.T..+..Q.D...K..l.+L.......I.V..Q..A..l..I..GV...W.L.V...s....A.L.A.LH....L......A..E.VGL....I.G.LS..V....I.IL.ATu...hT..G.V.TD.EHA.I.........GKA.F.......p.....Eu.L.PF.T..A.L..L..TV..FF.S.VVAVIIDQpL.....Fu.PII..Q.FVL.Q.....A...S..-.H....uQ..L....o...L..FY.l......F..NG..L...LSSISDNV.FVGT.l...Y..I...NEAKAAhEs.........G....sI.ohc......Q.a.EL......LAVAINTGTNLPSVATPNGQAAFLF..LLTSAL...APLIRLSYGRMVW..M..ALPYTlVLTLVGLLsVEFh.LsPsTEWhhphGWIu.o.....................................................................................................................................................	0	21	42	77
+6279	PF06451	Moricin		Moricin	Finn RD	anon	Pfam-B_56760 (release 9.0)	Domain	Moricin is a antibacterial peptide that is highly basic. The structure of moricin reveals that it is comprised of a long alpha-helix.  The N-terminus of the helix is amphipathic, and the C-terminus of the helix is predominately hydrophobic.  The amphipathic N-terminal segment of the alpha- helix is mainly responsible for the increase in permeability  of the bacterial membrane which kills the bacteria [1].	25.00	25.00	25.50	25.10	19.30	19.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.84	0.72	-4.46	2	23	2009-09-10 20:06:58	2003-07-09 11:52:21	6	1	10	3	6	26	0	39.20	59	54.24	CHANGED	uKIPItAIKpsGKAlGKGLRAlNIASTApDVasFhKPKKR+	..uKIPltAIKKuGKAIGKGLRAINIAuTAHDVaoahKPKK++....	0	3	6	6
+6280	PF06452	DUF1083		Domain of unknown function (DUF1083)	Moxon SJ	anon	Pfam-B_2203 (release 10.0)	Domain	This family consists of several domains of unknown function exclusively found in bacterial xylanase proteins (usually at the C-terminus) although it is tandemly repeated in a number of family members such as Swiss:P38535. This family is always found in conjunction with Pfam:PF00331 and usually with either Pfam:PF02018 or Pfam:PF00395. The function of this family is unknown.	20.80	20.80	20.90	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.34	0.71	-4.41	35	615	2009-01-15 18:05:59	2003-07-09 11:58:29	6	91	276	3	254	667	374	179.60	17	25.09	CHANGED	I.DGps.DssWssAp...lshsphh....tus.....sssoush+sLWD.-csLYlLscVsDsl.lscsssss....a-pDulEIFlDpsNsK...sstYpssDhQY+lsasNpso....hssss...........hssshpousphss.sGY.....llEstIsh............psl.....sssssph...lGFDltlND.ssssGsRpuhhsWsDsosss......apssusFGslpLttp	................................................lDG.h..-t.W.ppst....hs.....h.h................ts.t..........ssh..psp..s+.hha..D..c....psLYlh..s.......p....l...p....Ds.....p.....h.....p.....p......tttss.............ha...p...s.Ds.lE.l.a.l...D....ssssp.......psta.....p.......h......p.....s......s....t..h.........t....h.....t.h..s...s..h..t.s........hphtt..................................................hs.sth..p...s..t.sp.........h.........s.........s...sua..........hhEhtIPh.....................psl........t..t.ts.ph.....huhs...h..........h.p...............................................................t........................................................................................................................................	0	130	216	243
+6281	PF06453	LT-IIB		Type II heat-labile enterotoxin , B subunit (LT-IIB)	Finn RD	anon	Pfam-B_61882 (release 9.0)	Domain	Family of B subunits from the type II heat-labile enterotoxin. The B subunits form a pentameric ring, which interacts with one A subunit.  Thus, the structural arrangement of type I and type II heat-labile enterotoxins are very similar [1]. 	25.00	25.00	139.10	139.00	20.60	19.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.54	0.71	-4.44	2	7	2009-01-15 18:05:59	2003-07-09 12:17:58	6	1	2	15	0	7	0	121.70	64	99.77	CHANGED	MS.KKIItAFVlMsullSsQsaAGsSpaF+s.CNpTTAslVtGVpLpKYIuDlNsNTcGhYVVSsTGGVWhIstu+DYPDNhhouEhRKhAMAAlLSsh+VNhCApsuSSPNhIWAhEL-tE	MsFKK.IuhhhlhhsIsSl.sYAGVScpFKDpCspTTAclVpuVQLsKhhSDlNpso+GIYlsSSTGtsWaIPGGp.YPDNaLSsEMRKIAMAAVLSssRVNlCASpA.oPNHlWAIELttE..	0	0	0	0
+6282	PF06454	DUF1084		Protein of unknown function (DUF1084)	Moxon SJ	anon	Pfam-B_12888 (release 10.0)	Family	This family consists of several hypothetical plant specific proteins of unknown function.	25.00	25.00	25.20	25.20	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.83	0.70	-5.37	10	304	2009-01-15 18:05:59	2003-07-09 12:39:16	6	6	72	0	206	287	1	218.40	26	53.16	CHANGED	husosssult....ssWWDplNE.SshWQDsIFauLuulYGLVSsVALlQLIRIph.RVPEYG..WTTQKVFHLhNFlVNGVRAl.lFuF+.....+pV.plpPcllp..tlLLDlPGLsFFoTYsLLVLFWAEIYaQARu...LsTD+LRsuFaolNuVlYhIQIsIWlhlWhpPss....sl.hluKhFhAslShhAALGFLLYGGRLFlMLRRFPIESKGR+KKL+EVGhVTsICFoCFLIRClh....hslsAFDscAcLDVLsHPlLNhlYYllVEILPSuLVLFILRKLPPKRspsQYHPIp	....................................................................................hhh.........................................h.lshhhhhluhhuhhQ.l.h.......ph.......h....+.........p.hs......hs...hp+lhhhh.......h...l..s......s......h................h.Rsh...hFhhh.....................ph.....ht.........t..hhp......hlLhshPsh...ha.aosasll.llaW...sclha.....p.u.ps........h..t...p..t....l...p.........hhhl.Nsh..lY...h.h....tl..hl...al...h......h..h.hp...t.....................hh.hh..th......h.h....u....sl.....h...h.h.uh....u.FhhYGhpLahh..l.........p............p...........h.........p......t..p.t.....p......p..p...c..h............c..lshlshl....s.hsFhh+shh.......hh......h......s.....h.................t....h...t..........h.....t.....l...h...........hhhahhsEhlPs.h.lLahh.............................................................	0	75	157	185
+6283	PF06455	NADH5_C		NADH dehydrogenase subunit 5 C-terminus	Moxon SJ	anon	Pfam-B_3060 (release 10.0)	Family	This family represents the C-terminal region of several NADH dehydrogenase subunit 5 proteins and is found in conjunction with Pfam:PF00361 and Pfam:PF00662.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.01	0.71	-4.90	78	9824	2009-01-15 18:05:59	2003-07-09 12:48:11	6	10	5550	0	166	9403	1036	165.20	32	35.29	CHANGED	YShRllaashhGpsphsshsslNEss.hllsslhtLuhGSIhuGhhlohhlhP..psshhshPhhlKhhALhVollGllhuhplsshohp.hp.s......shppF.shhhFhP.lspphhsphsLhhGpplspp.hDpuWhEhhGspGlhph.hshophhpshQpu..lKhYLhhFllslllhhhhh	...........................................................................YShRlh...a..ashhG.p.....p...a.....o....l..p...s....l..N...-.p....s....h.h..lp..sh.htLhhhSIh.............uG...........................h...........l...............s..................................I...............h.................P......p................s......................h............h................s...................h.................P............h............................L...K......h......h.AL....h..V....o....l....l.G.h..h.l......u.............h.......-...........l...s....p...h....o.......................p.....h....h.....................p.....p.................t..................s...............h.hF..shh....hahPsl.ph.hhshh.s.Lhh.u..plhpp..hD.sW...E.h..h.Gsp.u.h..ph..h..p..o.hh.hp...Q.p.s..hK...h..Y...hh.hhlhhhhhhh...........................................	0	50	91	119
+6284	PF06456	Arfaptin		Arfaptin-like domain	Finn RD	anon	Pfam-B_5314 (release 7.5)	Domain	Arfaptin interacts with ARF1, a small GTPase involved  in vesicle budding at the Golgi complex and immature secretory granules.  The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix  coiled-coils [1]. The N-terminal region of ICA69 is similar to arfaptin [2]. 	32.00	32.00	33.60	33.40	31.20	31.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.31	0.70	-5.01	11	535	2012-10-03 12:17:00	2003-07-09 12:49:09	8	12	97	10	285	472	0	209.60	33	55.43	CHANGED	lhpKlc.......ppa+po+QlhpcphG+tpcp+h.ssDsEL-splElL+sspcpYtsllchscshpptlhplspsp+tLGchFppluh..Kspphscthstsu-sh+hluKpt.sLhsslphhlsclsTahs+sIsDThhTlcphEssRhEYcuhphclK-hspELsPpsstphshaRpsQsph.........ppsKc+a-KL+sDVh.Kl-LL-ps+spslsppLttapsslutaappsuctL	..........................................p+hp.......ppahpT+Qhh.cphG+tpc......ssD..s-.L-sp..lE.........lh+sspcphpsllch..sct...hppp.hhplsppp.ptLGchhpshu....co.thtcthshsucs.phhs+p.t...sLh.ss.lshhhp.slsThhp+sIpDThhTlpphEp..s.RhEYc.uhhh.hc-.h...s...hsPps........t..tp..h.+h..ctsQtph.........................pt.t+.p.pa-Kh+tDVh.KlchLtts+sphhpppLhha...p.ssl.taattstp.h......................................	0	83	103	191
+6285	PF06457	Ectatomin		Ectatomin	Finn RD	anon	Pfam-B_63420 (release 9.0)	Domain	Ectatomin is a toxic component from the Ectatomma tuberculatum  ant venom.  It is comprised of two subunits, A and B, which  are homologous.  The structure of ectatomin  reveals that each subunit is comprised of two helices and a connecting hinge region, the forms a hairpin structure that is stabilised by disulphide bridges.  The two hinges are connected by a disulphide bond [1].	25.00	25.00	82.10	82.00	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.84	0.72	-4.25	2	2	2009-09-11 06:57:38	2003-07-09 13:43:24	6	1	1	2	0	2	0	34.00	47	95.77	CHANGED	hsphlh.TlCPTlcshAKKCpGsIAThIK+cCsK	hsphlh.TlCPTlcshAKKCpGsIAThIK+cCsK	0	0	0	0
+6286	PF06458	MucBP	DUF1085; 	MucBP domain	Galperin M, Moxon SJ, Bateman A	anon	Pfam-B_4243 (release 10.0) & Galperin M	Domain	The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with Pfam:PF00746 and Pfam:PF00560.	22.60	22.60	22.60	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.82	0.72	-3.39	115	1918	2012-10-02 15:23:12	2003-07-09 13:51:03	7	136	317	12	279	1856	8	103.00	26	27.90	CHANGED	hspssshTlpYlct.s......Gspls.ss...........................-hlT..G..hh...........................................scsa...ssss...sI..sGY...............................sht..sh..sss.ss.hshssss.sV	..................................................h.sKslTRTIpYhts.s..............Gpp.....s......t....t.....s.....h.....s.Q.s..l........sao...................Ro.............ssh.DpVT........Gplsh..............................ssWss...............tsssa....stl...ssP......sl......sGY................ssshsssstpsV..................................ss.ssp...sh....phsVs..Yptpst......................................................	0	49	98	163
+6287	PF06459	RR_TM4-6		Ryanodine Receptor TM 4-6	Yeats C	anon	ADDA_12111	Family	This region covers TM regions 4-6 of the ryanodine receptor 1 family.	25.10	25.10	26.30	26.30	25.00	24.70	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.99	0.70	-4.50	21	301	2009-01-15 18:05:59	2003-07-09 14:40:33	7	42	92	0	144	243	0	247.80	36	6.13	CHANGED	sMPDPTQstl+G.....-h.ptccsth.ptssstp.h.......ustcEschhs-.....hhGlthcKEGu..h...hssssGLuDhuph.s.tssospsssht+p.........................ttttpsps-sphsDhcsGEK.....pp.sc.ppp...ppsh.t.httppp+spctcc..thhhphatt.............lphhppKhlNYLARNFYNLRaLALFlAFAINFILLFYKVosp.ss---c.t.........................................tsthss..----..-csh.hahLp......EooGYM.tPsLphLAllHTlISFhClIGYYCLKVPLVI	...............................................................................................................................hP-PTt.tl+s...........ph.pt...t...t..h..pt....t.t.h.......t.tt-t-hhs-.........hhGht.......c+EGu..p......htspsGLuDh...p..s...t.s..s..ttsshtct.........................................................t.ttptc..ps..cscc....A..-hEsGEK......ttt..ctp..t.............sp..p.p....tptpsp+h....tcs..ps.h.sphatt..................lp.happK..hLs..YLARNFYNLRaLALFlAFAINFILLFYK.Vosp.sstc.tpt.t............................................s.sshsp...-c--...--shlaahLp......ESo.GYM.pPsLRhLAllHTlISFhClIGYYCLK.....VPLVI..................	0	20	31	85
+6288	PF06460	NSP13		Coronavirus NSP13	Yeats C	anon	ADDA_12678	Family	This family covers the NSP13 region of the coronavirus polyprotein. This protein has the predicted function of an mRNA cap-1 methyltransferase function ([1]).	20.10	20.10	20.10	20.30	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.66	0.70	-5.55	8	426	2012-10-10 17:06:42	2003-07-09 15:53:49	7	37	250	4	0	450	56	280.30	61	5.15	CHANGED	uu-WpsGYuMPsLYKhQchsLE+CNLaNYGtslsLPsGIMhNVAKYTQLCQYLNoTTLsVP+NMRVLHLGAGSDKGVAPGoAVLRpWL..........PpssILVDNDlsDYVSDAchSlhGDCsTlhh-sKaDLlISDMY....DsppKslst-NsSK-GFFoYl.suhI+-KLALGGSlAIKlTEaSW.NtcLYcLhp+FuaWThFCTuVNsSSSEuFLIGlNYLGc.ss+spIDGssMHANYlFWRNoshhphSt.SlhDhSKFshKhpuTsVVsLKpppls-hVhuLlcpGKLLlRsssphlhhusphVsss	....................................................ussWpPGYuMPsLYKhQphsLEhCsL.NYGtslsLPsGIMMNVAKYTQLCQYL.NTs.TLsVPaNMRVlHhGAGSDKGVAPGo..sVL+QWL............PsGolL.VDNDlsDaVSDAcsolhGDCsolhhpsKaDLlISD.MY....DspTK.plsttNsS.K-GFFTYl.sshI+pKLALGGSlAlKIT...EaSW.NtcL.Y.cLht.c.FuaWThFC.T.sV.N.AS...SS.EuFLIGlNYLGc..sK.pIDGpsMHANYIFWRNoshhphSuYSlFDhuKFs.LKL+uTsVlsLK-sQlNDhVhuLLc+G+LLlR-ss+hlssuD.LVN...........................................	1	0	0	0
+6289	PF06461	DUF1086		Domain of Unknown Function (DUF1086)	Yeats C	anon	ADDA_2403	Domain	This family consists of several eukaryotic domains of unknown function which are present in chromodomain helicase DNA binding proteins. This domain is often found in conjunction with Pfam:PF00176, Pfam:PF00271, Pfam:PF06465, Pfam:PF00385 and Pfam:PF00628.	25.00	25.00	30.70	29.20	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.89	0.71	-4.41	4	315	2009-01-15 18:05:59	2003-07-09 16:22:00	6	49	98	0	143	249	0	148.60	65	9.03	CHANGED	.ssup........pctspsspRP.R++tR-sp-c..sPLhtt.GtplcVLGFNtpQRchFlpslMRaGh...s.hp.p..V.cL+tKo.c.FKtYu.LFh+HlsEsssDNSsoF........uDGVP+EGLsppcVLsRIulM.Ll+cKVQ.hEcasGc.shPphh.	.........tsssE-s--p.......cs..t..sRR..sR+.p..L.R..s-+DKP...LPPLLARVGG.NIE.VLGFNsRQRKAFLNAlMRaGMP..............PQDAF.soQWL......VRDLRGKSEKEF.K..AYVSLFMRHLCEPG...A...DGuETF........ADGVPRE....GLSRQ.HVLTRIGVMSLlRKKVQEFEHlNGcaShP-L..h................	0	29	51	89
+6290	PF06462	Hyd_WA		Propeller	Yeats C	anon	ADDA_3361	Family	Probable beta-propeller.	20.70	20.70	20.70	20.90	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.05	0.72	-7.38	0.72	-4.30	73	1060	2009-01-15 18:05:59	2003-07-10 09:19:19	7	43	91	0	606	1024	6	32.70	33	16.01	CHANGED	stVWAls.pc.........GplhhRp.......GlopssPpGss..Wppls	........tVWAls.pp........................GplhhRp.......Glos.p.s.PpGss..Wppl........	0	133	188	369
+6291	PF06463	Mob_synth_C		Molybdenum Cofactor Synthesis C	Yeats C	anon	ADDA_4938	Domain	This region contains two iron-sulphur (3Fe-4S) binding sites. Mutations in this region of  Swiss:O14940 cause MOCOD (Molybdenum Co-Factor Deficiency) type A.	24.00	24.00	24.60	24.10	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.86	0.71	-4.45	66	3853	2009-01-15 18:05:59	2003-07-10 14:48:39	8	19	3317	8	1051	2921	1184	127.60	32	37.19	CHANGED	hplRFIEhMshGpspph......cphlshpplhstlpppath..hsst.tps...susAchapl...........ssst.up.....................lGhIsshops.FCssCNRlRLTu-GpL+sCLatpps.h-LRshL+sss.stt....LtphlppultpKtttath	..............................................plRFIEhMshG.p......s.s.....th...tt...........pphlotpplh..sp.l...p.p...c.h...l......tt.hp...tpp.............suPAphaph................s.sht...uc.............................lGlIsshocs.FCuoCNRlRlou-GpLh.hC......LFupp....s..hsLRshL....Rss.......s....pppt.............Ltpt.lpps.l.ppK.ppa..h..............................................	0	333	659	885
+6292	PF06464	DMAP_binding		DMAP1-binding Domain	Yeats C	anon	ADDA_4672	Domain	This domain binds DMAP1, a transcriptional co-repressor.	27.00	27.00	27.00	27.70	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.26	0.72	-3.47	20	421	2009-01-15 18:05:59	2003-07-10 16:02:57	6	20	154	0	223	376	0	97.80	28	7.19	CHANGED	ssssLPt-VRc+Lp-L-h-hspGslTpKGYpKK+s+LLppFL.................................tscsppphtsppsth+cc.chpp-lapps.VpAhLsKptppchuhshsscccssh	...................s.......clpt.pLtpL-.-.hp.pGDITpKGYpK++spLLt...tal......................................................................t........t...........tst.......p.ph.phtst.psp..php..........pcha.htt.lpuhls+...p.c.........p...................................................................................................	0	35	62	128
+6293	PF06465	DUF1087		Domain of Unknown Function (DUF1087)	Yeats C, Sammut SJ	anon	ADDA_2403	Domain	Members of this family are found in various chromatin remodelling factors and transposases. Their exact function is, as yet, unknown.	20.80	20.80	20.80	21.10	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.18	0.72	-4.05	14	335	2009-01-15 18:05:59	2003-07-10 16:07:05	8	54	109	0	159	267	0	64.50	60	3.87	CHANGED	pthttcp-ps.s-shtt..ps.cssaW.cLL+++YEpppt-ctppLGKtKRsRKQVsYs-t.sslps	.....................c..Etcc.EElEREIIKQE..E.s..V.D...PDYWEKLL...........RHHYE..QQQEDLARsLG.KGKRlRKQV..N...YNDu.uQED............	0	34	65	106
+6294	PF06466	PCAF_N		PCAF (P300/CBP-associated factor) N-terminal domain	Yeats C	anon	ADDA_4771	Domain	This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold -  though predominantly helical.	19.70	19.70	43.40	23.00	19.20	18.00	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.75	0.70	-5.05	3	179	2009-09-11 14:37:09	2003-07-14 11:28:16	6	8	84	0	111	162	0	215.60	57	31.42	CHANGED	RIuQRKAQVRuLPRAKKLEKLGVYSACKAEEoCKCNGWKNPpPsss.PRtDLQQs.sssLoEpCR..SCcHuLAuHVSHLENVSE-EMNRLLGhVlDVENLFMSVHKEEDsDTKQVYFYLFKLLRKCILQRs+PVVEGSLG.cPPFEKPsIEQGVLNFVQYKFSHLuo+ERQTMhELAKMFLNpLNYW+LEoPSQRRtRSssEDlSsYKlNYTRWLCYCHVPQFCDSLPRYETT+VFGRTLLRSVFTlsRRQLLEKs	...........................t.s..pKl.KLuhaSuCp..upp.CKCsGWK....sPpssst.....s+..............hDlp..p....h.....sshs-.CR..oCpHsL.s.sHluHL.-slSE-EhNRLLGhVlDVEpLFhsVH...KEE..D.s.D.TKQVYFYLF.K.LLRKsILp.hs+PVlEGsLt....pPPFE+PsIp..p..uV.NFV.YKFSHL.s.s+EpQTh.hELuKMFL.plNaW+LEsPoph...RtR..s...s.-.Dh....usYKlNYTRWLCYCpVPphCDSLP+YETopVFGRoLL+SlFsshRRQLL-p...........................	3	27	34	74
+6295	PF06467	zf-FCS	zf_MYM; zf-MYM; 	MYM-type Zinc finger with FCS sequence motif	Yeats C	anon	ADDA_4806, Iyer L	Domain	MYM-type zinc fingers were identified in MYM family proteins [1]. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1 [2]. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1 [3]; in atypical myeloproliferative disorders it is rearranged [4]. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons [5].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.75	0.72	-4.32	56	1780	2012-10-03 05:12:49	2003-07-14 11:43:49	9	35	200	2	719	1712	47	41.30	25	16.45	CHANGED	ttssspspCphCpp.h..stpt......hphp......uphppFCSpsChspa	..........t...hhthpCshCpp.h.tptpp.........hphp......GphcpFCSpsChspa......	0	60	95	259
+6296	PF06468	Spond_N		Spondin_N	Yeats C	anon	ADDA_5023	Family	This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells ([1]). 	20.90	20.90	20.90	21.60	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.17	0.71	-4.62	17	420	2009-01-15 18:05:59	2003-07-14 12:07:36	8	35	159	3	258	396	23	167.40	30	35.50	CHANGED	tA+YclsFpGhWSppoHPKcaPhh..ss+aSsllGuoHossYphWp.GphASsGl+phAEtGsshtL-pElct..tup+l.....................................polhpshu...hsuh.sssGpssuphcVDs.pHphlShlshlsPSPDWhVGVsul-LCpss.sWh-phsl-LaPaDAGTDSGhTapSsNtsTlPt-hlppITop.PscPtuPFYsPcupphsP	.....................................Yph.h.t.Ws.t.aspp.aP.................spaSsll....G.suHsss.a.p.haphG.........ph..A.SsGl+phAEtGsst.tLt...p.-hpt..........t.sp..t..h.........................................................olhpshu............t.h....s.s.s.u..p....s...ps..ph...p.l-p...p+.ph.lShh...shlsPSPDWhV...G...l...s...u...hcLCp....ts..sW..hpp.hs...hsL...hP..aDAGTDuG.o....a...uss..p.P.t.h....hp..s.....p..ssah.......................................................	0	79	111	198
+6297	PF06469	DUF1088		Domain of Unknown Function (DUF1088)	Yeats C	anon	ADDA_5036	Family	This family is found in the neurobeachins. The function of this region is not known.	20.80	20.80	20.80	20.80	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.18	0.71	-4.84	6	183	2009-01-15 18:05:59	2003-07-14 13:31:26	6	14	83	0	96	151	0	165.00	61	7.11	CHANGED	EGRLLuHAMKDHlVRVANEAEFILNRQRAEDVHKHA-FESpCAQYsADRREEE+MCDHLIsAAKaRDHVTAsQLlQKIlNILTsKHGAWGs.u.sSpsp-FWRLDYWEDDLRRRRRFVRNPaGSoHsEATLKAuhEa...........sssE-plhph+cshpSQshsspN..scsEL.....lL-uD	..............EGRLLsHAMKDHlVRVANEAEFILNRQRAEDVHKHAEFE..............Sp..CAQYuAD+REEEK..MCDHLIoA....AK+RDHVTAsQ.Lh.QK........IlNILTNKHGAW............G...s...........s......u......t.............S..........p..........h.....+-FWRLDYWEDDLRRRRRFVRNPhGSTHsEAoLKu.AlEa................................uss.E.-tl.hKuKpsh+SQs..lssQN..sEsElhL-u............................................	0	26	35	61
+6298	PF06470	SMC_hinge		SMC proteins Flexible Hinge Domain	Yeats C	anon	ADDA_5420	Domain	This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction ([1]).  	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.20	0.71	-4.14	102	3948	2009-01-15 18:05:59	2003-07-14 13:45:41	8	39	2700	16	1605	3541	451	116.80	25	9.96	CHANGED	hpu.lhGhls-llpl..sppac..t.AlpssLGsplp.sllVcstpsApphlphlc.pt........p.....hG+s.shlsLsplpspthp......................................sst.llphlph.s...phptsl..phllussllscsl-pA..tpls	.................................................h..GlhGtlu-Llpl...cp...cap....t..AlEsuLG.s..........s.hp.pll.V..-..s..p..c..s..Appslph.L+.pp................................p......hGRs..TFl...PL.s..p..l.psps.h.s..tt.tt.........................................................................shssh.hh.-.ll.p....h..-.........tphps.sh....p....lLG.ssllscslcpAppl..............................................................................	0	578	968	1353
+6299	PF06471	NSP11		NSP11	Yeats C	anon	ADDA_6050	Family	This region of coronavirus polyproteins encodes the NSP11 protein.	25.00	25.00	37.30	36.70	18.30	17.80	hmmbuild  -o /dev/null HMM SEED	594	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.02	0.70	-6.32	11	410	2009-01-15 18:05:59	2003-07-14 13:59:22	7	36	245	13	0	420	0	562.60	60	10.13	CHANGED	scLQu..p..ssGLFKDCuKs.pslpPAaAsTalSlsDcaKss-sLAVplss..sssloYp+lIShMGF+hDlslsGYpsLFlTRDtAlRpVRuWlGFDVEGAHAstsNlGTNlPLQlGFSTGVsFVVpPpGhlsTcpGsshcsVsAKAPPGEQF+HLlPLM+KGpPWsVVR+RIVQMluDhLssLSDhllFVhWAtGhELTThRYFVKlGhEppCp.Cu+RATCYsSssss...YuCa...+HulGsDYVYNPahlDIQQWGYsGsLosNHDthCsVH+sAHVASuDAIMTRCLAIHDCFsKsV-WslpYPhIuNEppINpuCRhVQphll+AAlpsh+ssslaDIGNPKGI+CVsp.-scWpaYDppPlsp...sVKpLcYsYtsHtp.FtDGLChFWNCNVDpYPpNulVCRFDTRshSpLNL.GCNGGSLYVNKHAFHTPAaD+pAFt+LKPhPFFYYsDosCEshp.......cpV..sYVPL+ossCITRCNlGGAVCpKHAs.Y+pYlEuYNhhssAGFolWVs+sFDsYNLWpTFop...LQSLENlAYNVVKpGpFsGlsGELPVAIlNDKVal+ssssDshlFsNpToLPTNVAFELaAKRplphpPsls	........t.LQs.....psTGLFKDCSKphs.GlHPuaAsTahulsspaKss-s.LAVslss.hspshTYp+LIShMGFKhsh.....slsGYpshFITR-EAIRpVRuWlGFDVEGsHAst-slGTNlPLQlGFSTGlsFVVpspGhVsTcpGspFphVsAKuPPGEQFpHLIPLMp+GpPWpVVRhRIVQMluDpLpsLSDpVVFVhWAtG.hELTohRYFVKIG.EpsCs.Cs+RATCasSposs...YuC..W...+H....ul...G...hDYlYNPhhlDlQQWGYoGsLp.NHD.aCsVHtsAHVASuDAIMTRCLAla-CFsKcVsWslpYPhIuNE.plNsuCRhlQ+hhl+AAlhs.+hsllaDIGNPKuI+CVtp.-lpa+FYDtpPlss...sV+pL.YsYtsH+DpFtDGLChFWNCNVDpYPsNulVCRFDTRsLSsLNLPGCNGGSLYVNKHAFHTPsFD+sAFppLKshPFFYYsDSPCEhhs......sspl..DYVPL+SssCITRCNlGGAVC+KHAp.YRpYl-uYNhhsoAGFolWlh+sFDsYNLWpTFop...LQSLENVAYNlVppGHFsGhsGEhPsuIls-+Vhs+ssshDstIFpNpToLPTNVAFELaAKRsI+.hPpl......	0	0	0	0
+6300	PF06472	ABC_membrane_2	Ald_N; 	ABC transporter transmembrane region 2	Yeats C	anon	ADDA_6479	Family	This domain covers the transmembrane of a small family of ABC transporters and shares sequence similarity with Pfam:PF00664. Mutations in this domain in Swiss:P28288 are believed responsible for Zellweger Syndrome-2 [1]; mutations in  Swiss:P33897 are responsible for recessive X-linked adrenoleukodystrophy [2]. A Saccharomyces cerevisiae homolog is involved in the import of long-chain fatty acids [3].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.51	0.70	-5.28	26	2221	2012-10-02 13:23:42	2003-07-14 14:08:31	10	15	1284	0	895	2380	1271	271.60	24	45.53	CHANGED	hphsssFhpplhpLl+lhl.PphhspcshhLhslshhLlhRThlslhluphsuplhpsllp..............pshctFhhtlh.pahhlulssohlsshlcYhpscLtLpaRppLocalaspYLpsp.saY+huslDs....plsNsDQplTpDlppFs...........s.ssusLaoslsKPllDlhlasapL....hpssGttus..............hhlhsYlhhuus.ll+tlssPhucLssccp+hEGcaRahHsRLlsNuEEIAFYpGpchE+pplpppapsLlpphptllph+hhhshh-shlhKYhhsslGallsulPhF	.................................................h........phh..l.hp.hh..s..p.t..hpt.............hh.h.....l..............h..h..l..hh..h........h.l...h..ts.h........l.s....lhls..p.hs.....s.phh...s.u.L....p....................................................................p.sh..ptFh..p..hlh....h............a.......h...........h.............lhh...hh.....s..h.h.s................s.....h..............h.......pa........l.p....p.h.L....tl.pWR....phLTcth...hsp.ah...............s............s....p...s........YY+l..p...h..hsp.........................t.h.-.N.P................DQ....RIspDlpths............s.sshsLh........h........s...l.lpsllsll...hFshh.L....aph..uG.shsh.......................................hhhh.l...ashhu..sh...l.h.......p............h.lu..p...................lhpLshppp............+hEusa.........R...hshs+lpcp.......uEpIAh........ap..G...c...p.h...............Ec...p...............pl...pppFps.lhpsh.....pp.......l.......hptp..hh.......h.......shhpshh.....phhhshhshllhus.h...................................................................................	0	255	477	704
+6301	PF06473	FGF-BP1		FGF binding protein 1 (FGF-BP1)	Moxon SJ	anon	Pfam-B_14221 (release 10.0)	Family	This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development [1]. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2 [2].	25.00	25.00	41.80	25.60	20.00	21.60	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.86	0.70	-4.76	9	118	2009-01-15 18:05:59	2003-07-14 14:09:56	7	2	40	0	70	108	0	192.60	24	96.26	CHANGED	lphLohL.LLlsthhhspstK..psKstptussppt.p...s...............pG+FsTK-pssCoWtl...hpts.pslsL+VcCpptsps.....asCtasGpPppC.tapscsptYWKQlsppLR+p+phCpssp.lLKoRlC+Kssspuph.................+hlopsh.ssptscpchppssspcpstsptpss.cpp........t.ttshssphPch.s.....psss.tppp+hAhEaCsEoWpSLCsFFlshhpG	..........................................shl.hLhs.hhhsthtp......t.cttttpt....stt..............................pG+F.op.c....p.t....sCshth.............pt.t.tthpLplpCp....p.....spp.......a.C.atGpPp.C.tatsp.phYW+QlhttL++.+.phCpsst.sL+splCp.+.ts...puph...................phhspsh.st...t....sppp.......tt...t...st.....t...........t................t.............t...t...hh.s.......s.ph...............pss.s...p..ptchs.paChcpapSlCsFFlshhps...............................	0	3	11	31
+6302	PF06474	MLTD_N		MltD lipid attachment motif	Yeats C, Bateman A	anon	ADDA_7289	Motif	This short motif is a lipid attachment site.	25.00	25.00	25.10	25.30	23.40	24.20	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.45	0.72	-3.76	11	113	2012-10-01 23:27:00	2003-07-14 14:17:28	7	3	100	0	15	67	2	26.30	54	5.12	CHANGED	Mp...................hsphuhlhh.sLLsGCQo	......................htVphShVhA.hLLVGCQS	0	3	3	9
+6303	PF06475	Glycolipid_bind	DUF1089;	Putative glycolipid-binding	Moxon SJ	anon	Pfam-B_14397 (release 10.0)	Family	This family has a novel fold known as a spiral beta-roll, consisting of a 15-stranded beta sheet wrapped around a single alpha helix. It forms dimers. It has some structural similarity to the E. coli lipoprotein localisation factors LolA, Swiss:P61316 and LolB, Swiss:P61320. Its structure suggests that it may have a role in glycolipid binding. Its genomic context supports a role in glycolipid metabolism [1].	25.00	25.00	28.10	26.80	22.00	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.00	0.71	-5.13	30	291	2009-01-15 18:05:59	2003-07-14 14:32:26	6	2	259	2	90	250	11	175.50	34	93.19	CHANGED	tslpWcsh...-ssGhEplpl....ppsusultssuhlh.sppsups.hulpYclpsDssWpo+phplsshhutt.tplpltp-tcGpWhh.sGp...shssl-GslDlDluhoPFTNTLPIRRLsLst..GpstplsssalphPshp.lshspQpYopl..ss....phY+Ycusstu.......AclsVDccGhVlDYPsLacRl	.........................t..lpWpsh....-.hsthEplpl....ph.ssptlpsputll..utpssps.auhpYclt.sDtshts+chslpshhutt..ppLpltpD..tcG...t.....Whs..tssp...............thsshs.GslDlDlshoPFsNsLPIRRLGLtp......ucst..slsVlYVslP.....-.....hs.VssspQsYosh.ss..............pth+acossss.......sslsVDs-GhVlDYPsLhcRh........	0	24	50	68
+6304	PF06476	DUF1090		Protein of unknown function (DUF1090)	Moxon SJ	anon	Pfam-B_14862 (release 10.0)	Family	This family consists of several bacterial proteins of unknown function and is known as YqjC in E. coli.	21.10	21.10	21.10	21.20	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.50	0.71	-4.42	40	769	2009-09-11 09:53:20	2003-07-14 14:36:26	7	2	736	0	83	307	8	111.90	51	89.98	CHANGED	slsshlsssshus...ttt..hsGCssKtpsIppQIphA+taGNpp+lsGLcpALppVpscCoDsuLtp-+ppKltc.tcpcVsERpp-LpcAppc.......Gcs.-KIsK+pcK..LuEAppEL...pcA	..............lu..AlsLhsl.S.uuohA.....sohCQcKEQsIp.KEISYAcKHpNQsRI-GLpKALSEVRANCoD...opL+A-HpKKIA.......c.pK-.......EVAERQpDLsEAKpK.......GDA.DKIsKRc+K..LAEAQ-ELKK.l......................................	0	4	19	50
+6305	PF06477	DUF1091		Protein of unknown function (DUF1091)	Moxon SJ, Bateman A	anon	Pfam-B_14929 (release 10.0)	Domain	This is a family of uncharacterised proteins. Based on its distant similarity to Pfam:PF02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding.	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.23	0.72	-3.55	534	1212	2012-10-01 19:31:57	2003-07-14 14:38:56	8	13	19	0	714	1209	0	83.10	21	48.20	CHANGED	lphplhp+t.....ssacs.h.lashs.hDhCca...l...................p........hhphhaphhp..phS.Nh.scs....CPa...............stp....h..hlc.s.......hhhst......phlP.........l..P.pGp..Yhl	.....................................hhhp........ssac.h..las.hs.h-hCch...l..pp.....p.........p...s......hhphh..aphhp.....ph.o..N....h..scs.......CPh.........................pss..h....hlc.s.....hhhst..................phlP....h.PpGpYhh....................................	0	114	175	487
+6306	PF06478	Corona_RPol_N		Coronavirus RPol N-terminus	Yeats C	anon	ADDA_7507	Family	This family covers the N-terminal region of the  coronavirus RNA-directed RNA Polymerase.	25.00	25.00	84.40	84.40	18.70	18.00	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.25	0.70	-5.76	11	440	2009-01-15 18:05:59	2003-07-14 15:04:52	8	32	218	0	0	416	0	326.60	64	6.25	CHANGED	G.SSAARLEPC.NGT-sDhVhRAFDI....NKcVAslGKaLKsNCsRFppl.Dcc.......DuaFVVKRsTcSsh-HEQohYshLKsCsAVAcHDFFsa+cs+shhsNluRpcLTKYTMMDLsYALRpFDEpNC-lLKEILVhhGsCcpsY...F..-sKsWYDPVEN.DIaRVYApLGplVspAhLKsVtFCDsMVcpGlVGVLTLDNQDLNGsFYDFGDFlpshPGhGVPlssSYYSYMMPlhuMTNCLAuEsFhcuDl.upsaKsaDLLcYDFTEaKhsLFsKYFKYWs.pYHPNCsDCtDDpCllHCANFNsLFSTTIPsTuFGPLsRKlFlDGVPhVsTsGYHFKpLGlVaNpDVshHssRLS	.............SusARL.PCusGsssDVshRAFDIhN..ppsAGhupaLKsNCsRFQc......l....Dc.....c.....ss.L...DuaFVVKRsThosYp+EpshYphl....K........s........s........ssVApHDFFpFchstshlspIsRpcLTKYTMhDLsYALRHFDcpsC-sLKEILVpYus...Cc-sY....F.ppKDWYD.VENPcIhpVYt+LG.lVppALLpsVpFsDshV-tGlVGVLTLDNQDLNGpaYDFGDFlpsAPGsGVslsDSYYSYhMPllsMTcsLssEpahc.Dl.tpsa+paDLLpYDFT-cKhpLFsKYFKYWs.psYHPNCh-C.DDRCIlHCANFNlLFShllPsTuFGPLVRKlFVDGVPFVVosGYHaKELGVVhN.DVshHp.RLS..	0	0	0	0
+6307	PF06479	Ribonuc_2-5A		Ribonuclease 2-5A	Yeats C	anon	ADDA_8069	Family	This domain is a endoribonuclease [1]. Specifically it cleaves  an intron from Hac1 mRNA in humans, which causes it to be much more efficiently translated.	22.50	22.50	22.50	22.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.90	0.71	-4.29	32	447	2009-01-15 18:05:59	2003-07-14 15:15:02	7	36	256	47	292	416	4	126.20	36	13.94	CHANGED	c+LpFLpDVSD+hEhcsRcs.SshLphLEs.sutpVl..p.scWpp+lspshhssLs+a.R+..............YpssoltDLLRslRNKpcHYcEh.sccl+chlGslP-sahpYFspRFPcLLltsYpslt...phppcchFppYaps	...................................................................pcLpFlp.DVSD+hEhE.s...p................c..............u....s.......l.l.p...tLEp..s.......uptVl.......t..scWpppl.sts.l.h..s.sL.t....+.a...Rp.........................Ypuso.ltDLLRAlRNKpcHYcEl....P.........tcl..........p.p..............t............l...........Gs...l....P-..s.......a..hp...........YFssRFPpLLhp.sYpshp....thpp.-phFp.Ya................................	0	100	156	224
+6308	PF06480	FtsH_ext		FtsH Extracellular	Yeats C	anon	ADDA_8169	Family	This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes ([1]). It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In  Oenococcus oeni FtsH is involved in protection against  environmental stress ([2]), and shows increased expression  under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.29	0.72	-3.88	164	4553	2009-01-15 18:05:59	2003-07-14 15:26:04	10	9	3836	1	1188	3236	1943	99.30	18	15.13	CHANGED	hhlahllhlllhhlhhhh....................ttt....................pspplsa..opF.........h.phlp...psplppltlp...........tpph....................................................h.s.ttpsspthtshhhss....sth.pp.............ltpthtpt.slphssp.t	..................................................hlalllhlllhslhp.h.................................sssps.....................................sspplsY..SpF....................l.pplp.......pGpV.......c.plplp...........spphs...............................................................................................................s..pppss.......sp.....h.....ps....h...h.s.ss...........t.....pp..............L.sthhpt.slp.............................................................................................	0	356	719	981
+6309	PF06481	COX_ARM		COX Aromatic Rich Motif	Yeats C	anon	ADDA_8118	Motif	COX2 (Cytochrome O ubiquinol OXidase 2) is a major component of the respiratory complex during vegetative growth. It  transfers electrons from a quinol to the binuclear centre  of the catalytic subunit 1. The function of this region is not known.	20.90	20.90	21.40	20.90	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.97	0.72	-4.29	98	1360	2009-01-15 18:05:59	2003-07-14 15:39:44	9	4	1276	4	243	775	21	47.10	36	14.66	CHANGED	K....so.spsLs.tssYtpLu...pPSEppPVpaauoVpssLFpsllspahtttp	........KtS.spsLs.hssapcLA.........tP..SE.....h.......s....VpYFSsVcPsLFpslls+ahstt......	0	42	105	169
+6310	PF06482	Endostatin	Coll_NC10;	Collagenase NC10 and Endostatin	Yeats C	anon	ADDA_828	Domain	NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor ([1]). Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to ([2]).	23.20	23.20	23.70	23.90	23.10	22.80	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.15	0.70	-5.03	11	375	2009-01-15 18:05:59	2003-07-14 15:52:32	6	57	98	17	154	356	3	193.10	29	28.00	CHANGED	GsusGssshpohpsMlspu+phPEGsLlalh-cp-LYlRVRpGa+plhLsshsPlssss................................PPsshhh........................................s...t.hhspP.phsphp...................ts.hhppsPtPssssss...cscpp.tPsLHLlALNsPhSGsMRGIRGADFpCFQQARssGLtGTFRAFLSSRLQDLYSIVRRADRtslPIVNL+D-VLFsSW-ulFoGutu.hpsusRIaSFDGRDVLpDssWPQKhVWHGSsscG+Rhs-oYCEsWRTsspusTG.ASSLt.uG+LL-QputSCpssaIVLCIENSFMTptpK	.............................................................................s.............................................................................................................................................................................................................................................................L+hhALNtP..s.G.sh......p.............AD....h.CapQucthGh..hs....T.a+AFLSS......+lQsL.plVp.s-R..thPllNh+splLF.sWpshFs.s.p.......t.u..h.....p..t..laSFsG+slhtcstWP.K...lWHGS.s...tG...R........ppaCcsW+stt....h.u.uu.l.............s............t..hl.t.Q..p.........t..CttthhlLClE.............................................................	0	36	49	101
+6311	PF06483	ChiC		Chitinase C	Yeats C	anon	ADDA_8334	Family	This ~170 aa region is found at the C-terminus of Pfam:PF00704.	20.50	20.50	22.50	20.50	18.90	20.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.05	0.71	-4.54	20	239	2009-01-15 18:05:59	2003-07-14 16:00:39	6	10	178	0	35	173	3	178.60	51	18.04	CHANGED	EYhMGsThTohhY-KFssA.oPYG.sp.tushshPspulDlslshosFtlGDsNYPIsPclplTNNSssslPGGochpFDlsTSsssphpD....QSGhGlpVlsSGps.sGsNlGGL-s-FHRVuhoL.....PuWpoLAPGuoh-lshsYYLPlSs.PSNasVshsGppYulpt-aPpLP...hss.suuGs......G	..EYthGsTMTphhY-KFpsA.oPYG.s+...hussshPspslDlsVslsuFplGDpN.YPINPKlsFTNNoslsIPGG..ocFpFDlPsSusDssKD....QSGuGLKVIsSGHT.pusNlG.GLcGshHRVAhoL.....PuWcoLPAGuoY-lDMVYYLPlSG.PuNaoVplssppYuhph-..PsLPss-.hsssGss.ss...........	1	10	16	28
+6312	PF06484	Ten_N		Teneurin Intracellular Region	Yeats C	anon	ADDA_8545	Family	This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional  regulatory activity ([1]). The length of this region and  the conservation suggests that there may be two structural domains here (personal obs:C Yeats).	20.20	20.20	27.90	38.40	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.21	0.70	-5.34	4	409	2009-09-11 06:34:01	2003-07-14 16:08:25	7	28	37	0	154	368	0	172.60	36	11.44	CHANGED	RSLTp.RpDTE+RYTSSSADSEDuKls..KSYSSSETLKAaDpDSRhsYGsRVKDhVH+EsDEFSRQGssFoL+-LGhGEssPsHhusYRoDMGLPHpsYSlSsuSDADTETDGlMSPEHAVRLWGRS.TKSGRSSCLSSRANSNLTLTDTEHENTEN..........................GPPLHCSSASS.SPl-QhP....PPPS.AANpsQttLLGsS.....uApsupDS-SE-EFuPNSFLVKosSGNlhsPttAsup..ssaQNHSRLRTPPLPLsHsHoPS..HHsASINSLNRuNYTpR.SN...PSPAPTDpSsssEsPsu.Q-SlpsQDNWLLNSNlPLETR.................................HFLFKPG.GTSPLaCTTSPGYPLTSSTVYSPPPRPLPRNTFSRPAFsLKKPYKaCNWK	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................shp.t............p....................st.........s.hppsWlLsSNhsLEo..R..........................................................pFLFK.u.Gooshhssss......sY.shsosoVYosPsR.LPRsohs.R.hFphpKs.+hCsW+...................................	1	7	22	53
+6313	PF06485	DUF1092		Protein of unknown function (DUF1092)	Moxon SJ	anon	Pfam-B_14522 (release 10.0)	Family	This family consists of several hypothetical proteins of unknown function all from photosynthetic organisms including plants and cyanobacteria.	20.10	20.10	20.50	31.90	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.74	0.70	-5.44	37	156	2009-01-15 18:05:59	2003-07-14 16:19:01	6	2	107	0	74	169	167	260.20	36	87.46	CHANGED	WELDFYSRPll-pcGKKhWELLIssssps........FcaschCPuscVNShWLpsALpcAltt........uhttPp+lRsaRspMpohlp+AspplGlpshPSRRTauLhcWLpcRpcplYPpp.GY.s..hssss.sh.tssPhPLP-ulpGDp...WsauuLshuslp-ht.-W...slsFss....lhPls....hsLss-........t.lPGlhlFSppRuLsLAuWluGLEPspLphpss......pLlLEuG.sD+Wlluslp.sspspttupsapps+ppupGLpFlulQssPpspsFsGFWlLc-	...........WELDFYSRPllDtpGKKhWELlIC-ssts........hpasphCPssplNShWLppAlppshtp........uh.hPpplRhFRspMpshIp+Aspcl.....ulpshsSRRThuLhpWLp-R.pplYspp.Gapt.....ts.ssls..hsp.ssPhsLP-sLhG-p...Ws...FlsLshuslp...-...h....-h...sls.Fup....hhPls....hsLsss........shIPGlhlaSs.RuhsLAuWhuGLE.stLphpss.............tLlLEsGhs-+Wllushp..sspstt....tApsaEpsKptupGLHFLulQs.sssupsasGFWLLpp...........	0	17	55	70
+6314	PF06486	DUF1093		Protein of unknown function (DUF1093)	Moxon SJ	anon	Pfam-B_15034 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.50	21.50	21.50	21.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.50	0.72	-3.62	59	1369	2009-01-15 18:05:59	2003-07-14 16:22:07	6	2	510	4	84	672	2	79.20	26	65.84	CHANGED	sshhttcshYspIsss...ucppspp.............tpYpYphpuaccsGcc+plpa...sus.....+pL+psuYLKlphpspp..........VpsacEVpcc-	.............................shhttcshYsplsps........upchsp..............pthpYphsuasccGcccplpasus........ppL+.pssYLKlhh....ps+c............Vpsa-Elpcc..................................	1	23	44	63
+6315	PF06487	SAP18		Sin3 associated polypeptide p18 (SAP18)	Moxon SJ	anon	Pfam-B_15078 (release 10.0)	Family	This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides [1]. SAP18 is also present in the ASAP complex  which is thought to be involved in the regulation of splicing during the execution of programmed cell death [2].	20.80	20.80	20.90	21.60	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.62	0.71	-4.31	26	277	2009-01-15 18:05:59	2003-07-14 16:37:32	7	8	228	5	202	279	0	126.60	42	57.63	CHANGED	t.t.lDRcpTCPhLLRlF.hppspaasls-as............................splP.tsELQIYTWhssTLRELspLl+-.....s..ssR++GTphsFtllaPDt+p.........upYls+-lGoshs..Gt+ss..................................D-sKTLpst+FpIGDalDluI	...............................s...lDREKTCPh..LLRVF.hp.sGpHHph..s.-Fs.....................................t....uslP.psELQIYTW.......hDuTL+ELosLl+-............shstsR++GT+hsFslVaPDh+p..................stahh+-lGsshs....Gpcss........................................................................D-s+TLtsh+FpIGDYlDlAI..................................	1	70	107	158
+6316	PF06488	L_lac_phage_MSP		Lactococcus lactis bacteriophage major structural protein	Moxon SJ	anon	Pfam-B_13945 (release 10.0)	Family	This family consists of several Lactococcus lactis bacteriophage major structural proteins.	20.20	20.20	20.20	31.10	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.74	0.70	-5.36	2	78	2009-01-15 18:05:59	2003-07-14 17:14:50	6	6	55	0	7	54	0	214.50	62	72.90	CHANGED	MKLDYNSREIFFGNEALIVADMsKGSsGKP.FoNHKIVTGLVSVGSMEDQAETNSYPADDVPDHGVKKGATLLQGEMVFIQTDQALKEDILGQQRTtNGLGWSPTGNWKTKCVQYLIKGRKRDKlTGEFVDGYRVVVYPHLTPTAEATKESETDSVDGVDPIQWTLAVQAT-SDIYLNGDKKVPuIEYEIWGEQAKDFsKKMESGLFIhQPDT.LAGtlTLVAPslsNVpTtTKGNNDGTIVlPsTLKsSKGpsIKVTuVIKDs+GpVATNspLAPsVYIVTFSA-GYtDVpAGVuVTs+s	.........................................................................................................................................................................................................................................................................................................LAGsl..TLVAPshs.s.sTTus.KGssDuThslPsTLKDScGusVtVTSVIpsupGpssTN.GpLusGsYhVTaSA-GY-DVTtulsVTD.....	0	2	2	2
+6317	PF06489	Orthopox_A49R		Orthopoxvirus A49R protein	Moxon SJ	anon	Pfam-B_14072 (release 10.0)	Family	This family consists of several Orthopoxvirus A49R proteins. The function of this family is unknown.	25.00	25.00	79.10	78.80	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.21	0.71	-4.26	2	38	2009-09-11 15:19:44	2003-07-14 17:19:49	6	1	18	0	0	29	0	147.10	88	99.93	CHANGED	MDEuYYSGNLESVLGYVSDMHTcLASIoQLVIuKIETIsNDILNNsIVNFIMCRSNLNN........lYhh.c.pIY.......................aY+..................................................SpDlpERh.	.....................MDEAYYSGNLESVLGYVSDMHTELASISQLVIAKIETIDNDILNpDIVNFIMCRSNLDNPFISFLDTVYTIIDQEIYQsELINSLDDNEIIDCIVNKFMSFYKDNLENIVDAIITLKYIMNNPDFKTTYAEVLGSRIADIDIKQVIRcNILQLSNDIRERYL...........	0	0	0	0
+6318	PF06490	FleQ		Flagellar regulatory protein FleQ	Studholme DJ	anon	Pfam-B_13480 (release 9.0)	Domain	This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators that are involved in regulation of flagellar motility e.g. FleQ in Pseudomonas aeruginosa.  It is clearly related to Pfam:PF00072, but lacks the conserved aspartate residue that undergoes phosphorylation in the classic two-component system response regulator (Pfam:PF00072).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.16	0.72	-3.90	47	334	2012-10-01 22:20:39	2003-07-14 17:20:29	6	6	327	0	79	856	142	112.00	30	23.81	CHANGED	+lLll-ssspRppsLssILcFlGEp....sphhsssph.....tstthpsphpuhslhhssss......ptlpsltpthsthPlLllGcpsts....phss......llGpl-hPlsYspLs-hL++sQh	..............+lLlI.-DD.upRRpsLssIL...c.FlGEp....spsh.s.u.p.ph.....sphshs.ssh.ps.h...h..l..h.st.ssp......thtphLp.pl..h..s...t..s..s..a.lPlLlhscps.s......chss..........................hlG.p...L-hPhsYspLp-.uL++sp.................................................	0	17	34	59
+6319	PF06491	Disulph_isomer	DUF1094;	Disulphide isomerase	Moxon SJ	anon	Pfam-B_14101 (release 10.0)	Family	This family of proteins has disulphide isomerase activity, EC:5.3.4.1. It has a similar fold to thioredoxin, with an alpha-beta-alpha-beta-alpha-beta-beta-alpha topology. It has a conserved CGC motif in the loop immediately downstream of the first beta strand. This motif is essential for activity [1].	25.00	25.00	31.10	31.10	19.30	17.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.67	0.71	-4.32	28	820	2009-01-15 18:05:59	2003-07-14 17:22:22	6	1	476	4	121	346	200	135.90	57	94.58	CHANGED	Y.cplVpPMRpELopuGFcELpTsE-V-pshp...p-GTTLVllNSVCGCAAGlARPAAstAlpp.-++PD+LVTVFAGQDKEATs+sR-.YF.hsaPPSSPShALhKDG-lVahIcR+cIEG+ssptIsppLtsAF-caC	.....YMpplVpQhRsElspuGappLpTuEsVcchhp...pcGTTLVhlNSVCGCAuGlARPAAspulph..-+pP-+LVTVFAGQDKEATs+hRE.YF.tshsPSSPSaALlKssclVchlcRHpIEG+-h.slhtpLpssF-c.C............	0	44	86	107
+6321	PF06493	DUF1096		Protein of unknown function (DUF1096)	Vella Briffa B	anon	Pfam-B_15011 (release 10.0)	Family	This family represents the N-terminal region of several proteins found in C. elegans. The family is often found with Pfam:PF02363.	25.00	25.00	26.20	26.20	18.20	18.20	hmmbuild  --amino -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.74	0.72	-4.01	10	23	2009-01-15 18:05:59	2003-07-15 10:07:56	6	4	5	0	23	16	0	53.70	49	14.66	CHANGED	pusslR-KRQ.uCGCA..ssQPoCuCQpusps.............QpSCSC.ps.QP.........ouCuCA	..t.usslR-KRQsCuCAP.spQPpCuCQ.psshs..s............tQ.sCoC.psssP.Q.......suCsCA................	0	6	12	23
+6323	PF06495	Transformer		Fruit fly transformer protein	Moxon SJ	anon	Pfam-B_13780 (release 10.0)	Family	This family consists of transformer proteins from several Drosophila species and also from Ceratitis capitata (Mediterranean fruit fly). The transformer locus (tra) produces an RNA processing protein that alternatively splices the doublesex pre-mRNA in the sex determination hierarchy of Drosophila melanogaster [1].	26.10	26.10	26.60	26.10	25.20	26.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.69	0.71	-4.40	4	112	2009-01-15 18:05:59	2003-07-15 14:07:55	6	5	25	0	9	111	0	154.90	62	79.37	CHANGED	MDADSSupp.RDoR..................RcuRpKE.KlPYFADElREpDRlRpLRpRtpppTR..............RoRSRSRSpSu-RssppRR+RpRSpsRp+Sto.........Rp+osSS....pRRRRpRS.pR.hs.sP+IIsh.V.VPstDa....YG.........hSuM.tuhsYth.PRP....PPa......PPhPFRYRt.sPFhstPRF	.............MDADSS.stp.R.D.TR.........................RRPRQRE....KMPYFADELRERDRVRNL.RKLKTT..QKR.TP..TPPPRERRSRpARoRSRSRTHSsEQSRCpRR.RSR.....SYV.....R.QRS..GS.........RH.Qo.SS.Ss.....sRRR+SRSRSR...RSRTPRIITVPVPVPAAEY.uYAYs..........h.........................................................................................................	0	2	3	6
+6324	PF06496	DUF1097		Protein of unknown function (DUF1097)	Moxon SJ	anon	Pfam-B_15055 (release 10.0)	Family	This family consists of several bacterial putative membrane proteins.	22.30	22.30	22.30	23.20	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.94	0.71	-4.38	53	1004	2009-11-03 13:31:05	2003-07-15 14:16:43	6	2	730	0	102	428	24	140.50	53	85.64	CHANGED	AlosGlLuulWshl...AsshsLs.sW.....sGFlussoaFAt.tsGhpGhhtohsoshoGlhWAhlhltuuuhh.sh......shhuhlhsulsshhMshtAph.phL.uFlPGsFlGssuTFAs..................ssshhhllsuLllGslhGashphhuthLhp	...................................AlTTGILSGlWuWV.....AsuLG...Ll.oW.....AGFLGCTuYFAsPpGG...hKGLhhShsT.hSGhVWAhlIIhuS..uhhspl........plluYll.TullAF..lMClQ...A....+p...h....LL.SF...lP.GTFIGsCATFAu..........................................tGsW...p..lVLPSL....hlG.hlFGYhMcsoGlaLu.t............	1	23	50	72
+6325	PF06497	DUF1098		Protein of unknown function (DUF1098)	Moxon SJ	anon	Pfam-B_15446 (release 10.0)	Family	This family consists of several hypothetical Baculovirus proteins of unknown function.	21.30	21.30	21.50	40.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.19	0.72	-3.93	22	51	2009-01-15 18:05:59	2003-07-15 14:19:53	6	1	51	0	0	48	0	97.70	30	85.45	CHANGED	ppp......ppsppsspsss............sssplLpuLsp...posAphIlsDsStsKpssLppLuppStsAK+llcuIps.sp-slpl.ss.cslslLcllsDIasNph	..............p......ppstps.ss.sp...........hssschLpsLNp...pTsAshIlsDso.sKppuLphLuppSssAKplL...-slps.ssssl+L.sshcslslLcllusIaDNph..	0	0	0	0
+6328	PF06500	DUF1100		Alpha/beta hydrolase of unknown function (DUF1100)	Moxon SJ, Bateman A	anon	Pfam-B_15719 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	411	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.38	0.70	-5.90	5	738	2012-10-03 11:45:05	2003-07-15 15:59:26	6	3	717	10	104	985	155	396.10	61	97.14	CHANGED	tsSKNLSETLFpsHKQAKETSoLTQYMPoSp..slLDsl-pcoupuWYRpLRRLQWlWQGlDPlEhE-VLARIASSKHSRTcD-WLDTVMGYRSGNWsYEWs+lGMhHQ++AsEcssE.sAu-phFsAALhYSIAGYPHLKuDNLAlQAQVLAN+AYpEAAK+osYTlKQLEFPapc.uKIoGaLHLPs.TDuPaPVVLVSAGLDSLQTDMWRLFRDYLAP+DIAMLTIDMPSVGaSS+WPLTEDSSpLHQAVLNpLsslPWVDHaRVGLlGFRFGGNAMVRLuFLEs-KlKACVsLGAPVHDLFoSPcKLQpMPKMYLDVLASRLGKusVDlcSLuGQMsAWSLKVQGFLSGRRTKTPILAhuLEGDPVSPYSDNQLVAhFSssGKAKKIsSKTIocGYEQSLDLAIcWLEDELp	..................................................................................................MoQANLSETLFKPRF..KHsETSTLV...RR...h..s+..Gup..sslQ..S..A...LDG.c.olsHWYRMINRLMWIWRGlDPpEIL-VQARIVMSDAERTDD-LaDTVIGYRG...GN...WI.YEW..A....pQA....M.s...W....Q...Q...KA....s...t....E....p....D....s....hoGR.a.W.LH.AAsLYsIA..A..Y......P...H.....L.....K.....G.....D...-....L....A....E....Q..A....Q....A....L.....u.....N.......R...A....Y.E....E...AA....Q..R..L....P.Go...h..Rp..h.EF.s.....l.........P......G.....Gu......P..........I..T..G....F......L......H.....M...P........K.......G...............D.....G......P...F....P....T.V.L.M..C.GG....L.....D...u..h.....Q....T...D.......Y.......Y......s...L....Y....E...+...Y...FA.PRGIAMLT..ID.........M.........P....S...........V..G......F.......S........S.....K.......W....K.....L.....T.....Q.....D....S....S..l..L.....H.....Q.....+.....V.....L...+....A....L....P....N..V......P.......W......V...DH...TR..VAA.FGF.R.F.GA.NV.A.V....R.LA..YL.E.u.s...R......L...KAV.A..C......L...GP...V...V...H...s..L...LS....D.........p....pQ.....p....p.....V.....P...E.....M.....Y....L.DV...L..ASRL.GM.H...D..A..S......D-.A.......L..R.VE.L.N...RY.SLKVQGLL..G.RR...CPTPM.LSGaWKNDP.FSPEED.SRLIToS.SuDGKLlEIPFsP..V.Y+..NFD.+uLpEIocWIE+RLC..................................................................................................................................	1	16	42	73
+6329	PF06501	Herpes_U55		Human herpesvirus U55 protein	Moxon SJ	anon	Pfam-B_15779 (release 10.0)	Family	This family consists of several human herpesvirus U55 proteins. The function of this family is unknown.	20.40	20.40	20.40	21.40	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.53	0.70	-5.91	3	7	2012-10-03 01:18:03	2003-07-15 16:04:15	6	1	5	0	0	51	0	426.60	42	95.40	CHANGED	oS-Ls+llQlslDaN-.lQuc.Nao.lhlcCllS+T+PVLLLITDGTEScsEDVhFsu+sLcccpsIKI+lhPlsRoI.Ps+VplFulPIapIoSSLlIpD.shh..KENhDPpcaEQaGlhspsIuTTNlIs.lpsVpNcslElolTlFNIsWccSsYQsplccosG++LpTlaoVFSlNTspCPYWpshF+..SshPlC+VpMISEPsVSVYKIEFssPlLpVFLRshsLsspNsRFsVspEChLRLsF.ScPshsoVoLNlsMPYFKICuDtKslEVFFP-cMoLssNcsKcIsLRGTFpNhsAVGLFIPcposVlp.aPFlWpPpEoF+l+VoC-RospVTEHDIIG+VYFIo++lFR+sF+PsusuDhKSclEtspNoscsFclaFLGNcFFussLP-LTLHPhhshcYEclQusuNIpp.s.NcsPShpRlRl	.............................................................................ospLs+llQlshDhNc.l.sp.sap.lhlcChlSpT+PslLhITDGTEScsEDVhFssphLcpppsIKI+lhPlsRol.Ps+lplFulPIah.osuL.IpD.shh..KENhDPhhaEQaGlhshsIuTTNlIs.hpsVpNcslEholhlhNlsWpcSsYQsphhcp.G++LhhlaolFSlsTppCsYWpshFc..ShhPlC+VpMISEPslSlYKIEFssPhLplFLRshsLsppppRFslspEChLRLsF.S.PshsoVoLNhsMPYFK.IC.uDtK.slEVFFPscMoLs.NpsKcIsLRGpFpNhph.VGlFIP.spopVhp.aPFlW.spEsh+l+loC..-+.ospVTEH..DhlG+laFlo.++lFR+.sF..+shu.suDhKShlpt..spNo.scsFclaFhGNsF.u...L.P-LTLH.Ph.....cYEch.upuN.ph.s.scp.Shh+hRl.....................	0	0	0	0
+6330	PF06502	Equine_IAV_S2		Equine infectious anaemia virus S2 protein	Moxon SJ	anon	Pfam-B_15780 (release 10.0)	Family	This family consists of several equine infectious anaemia virus S2 proteins. The function of this family is unknown.	18.90	18.90	20.80	22.30	17.00	15.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.31	0.72	-4.11	2	41	2009-01-15 18:05:59	2003-07-15 16:07:45	6	2	2	0	0	41	0	65.30	75	83.19	CHANGED	MGlFGKGVTWSA.HShG.SQGE.QPL.PNpQpp.ohR+p.ha..N.IVIhhsl+ptWQppcpQ-TKK	.....MGLFGKGVTWSALHSMGV.SQGEYQPLSPNKQNQQTH+KtIhWYINPIVIMhAIKpKWQRQETQDTKK....	0	0	0	0
+6331	PF06503	DUF1101		Protein of unknown function (DUF1101)	Moxon SJ	anon	Pfam-B_15836 (release 10.0)	Family	This family consists of several hypothetical Fijivirus proteins of unknown function.	25.00	25.00	77.70	77.60	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.07	0.70	-5.64	5	109	2009-01-15 18:05:59	2003-07-15 16:10:46	6	1	9	0	0	40	0	317.00	82	99.67	CHANGED	M-RuoREHsKFSKANT+sEs+pMRhYKDDSsD-lsYSEIsVGlooooP+MuLSDYFSuVSloF-sEtRl-ElcPhlYuDLpF.p-pYspDVDLNLLlWQLLSuNQDS+ALCVNlLRMlsTluhGNAaIsc.GpY+Y.spsTs-pTss-DlDuLRlluRlAKIlIKsshsKsD.L+ssQcpLIpYapG+ua+SloLoWDSKSlLsolHGYS.TSEslLDaYIRpKL.DLFKuLpssNLVYGGNYpLVYQlLFYYYIlTNGRaSoGFosR+-S..IKoYslPNDsPusCNso.PRKPoLSLMaIRAlLlIsLIKDYSPlKplPlYlppLElEcPhpNoshlTDuGIRoEs-shssosslsts..LPsFSSsuu	..........................pEMRIYKDDTAsGLCFSEINVGCTSooPKMuLSDYFSSVSCSFDGEMRhPDlPL+hYGDLHF.H-QFTNDVDLDLLCWQLLSSNQDSRALCVNILRMlTuLSLGNAFISE.GRYHY.AlDTTEpTSAEDsDALRhLuRlAKIVIKNslcppD.lshAQQsLIYYYFGsSapGIHLNWDS+SSQ.SlHGYS.TSEsCLDHYIRMKI.DLFpGlRsKN.VYGGNYQLVYQALFYYYllTNGRFSSGFsVRKDS..IpSYFlPN-sPSsCNVo.PR.KPSLSLMFIRAlLlhhLIKDYSs.......................................................s....................................	0	0	0	0
+6332	PF06504	RepC		Replication protein C (RepC)	Moxon SJ	anon	Pfam-B_15903 (release 10.0)	Family	This family consists of several bacterial replication protein C (RepC) sequences.	22.80	22.80	23.30	23.50	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.98	0.70	-5.46	5	105	2012-10-04 14:01:12	2003-07-15 16:17:02	6	1	87	0	15	72	6	265.80	61	93.70	CHANGED	tscsAMsaDLTHARHDPAHCLAPGLFRSLKRGERKRLKLDVTYsYG-DcplRFsGPEPLGADDMRlLQGLVAlAG.....P+GIlLoPEPcSEuG+QLRLFLEs+WDAlEpDAMVVKGSaRpLASElGYATDGGusFKAIRESIERLWsVSVIVp+GuKRQGFRLLSEYASDEs-GRLFVALNPRIAEAIlGcRPHTRI-MAEVRALQTDPARLlHQRLCGWIDPGKSGRVELDTLCGYVWPD-ANuEAMKKRRQTARKALsELAAVGWTVNEYAKGKWEIoRPKPsu	..................................................................................................h.....pasLoHsRHDPAHCLAPGLFRuL...KR.....GER...K.RsKLDVT.Y.cYG-G.ccIEFsGPEPLGADDLRILQGLVAMAG......PsGLVLuPE.PpTEuG+.QLRLFL.....EP..K.WEAVst..D.AMVV.KGSYRALA+EIGhts.DuGssh..KtIp-CIERLWcVSI...IA..Q.....sG.R..K..RQ.....GFR...LLSEYASDEs.DG..RLYVALNPLIApAVMGG..uQHVRIsMcEVRALco-sARLlHQRLCGWID.PGKo....G+sslDTLCGYVWP.sE.A.su...uTMR...K....RR.Qp.lRcALs.ELs........A........L.GWTVsEaAtGKa-IsRPKssu..............	0	4	9	12
+6333	PF06505	XylR_N		Activator of aromatic catabolism	Studholme D	anon	Pfam-B_2890 (release 9.0)	Family	This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators in several proteobacteria, including activators of phenol degradation such as XylR. It is found adjacent to Pfam:PF02830.	20.80	20.80	21.00	21.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.09	0.72	-4.60	16	223	2012-10-02 19:02:47	2003-07-15 17:16:43	6	10	157	0	87	229	15	101.30	39	18.53	CHANGED	DLspplpFusp-GcIWLs-QRMLLlHsuuLuuLR+ELlpslGh-+ARGhhhRhGatuGtRDAclsRchRssusthshFhAGPQLHsLEGhV+Vpslph-....hDhp	.........DLpppLpFsspsGpIWLs-pRMlLl+ssuhu.s.LR+ELIcsLGh-pAR.......GlhhRhGYtu....Gh+DAcls.+chh.ss...s...s.hphFhsGPpLHsLcGhV.+VpslphchD..p.........................	1	17	50	76
+6334	PF06506	PrpR_N		Propionate catabolism activator	Studholme D	anon	Pfam-B_10794 (release 9.0)	Domain	This domain is found at the N terminus of several sigma54- dependent transcriptional activators including PrpR, which activates catabolism of propionate.	23.10	23.10	23.10	23.10	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.60	0.71	-4.87	47	943	2009-01-15 18:05:59	2003-07-15 18:17:36	6	25	691	6	118	633	15	172.70	37	30.19	CHANGED	plstchst.hclp..lhpsshp-ulphhcph.tt.ctsDlllutGu.sushl+ppl.slPVV.lpsouaDllpALtpA+....chs.....sclulVsappsh..u....hpphpphl.sl..slpthsapstc-scstltplpppG..hplllGsulsschA.pphGlpulLlhS.cpolcpAhccAhclsphtcpc...tp+	..........................s.l.hca-p.ssls...l.phsh-.cAls......hlcct..ts..ccsDsIIusGu.suuhLKs...+l..s.....l...PVl.I+sSGaDl....LpALsc.At.....c..hs........usIGlV.sa..ppsl..su....lhsapcth..sl.....clcpts.a...h....o.....c...E.-......uc....splp.cL+....usG..h-slVGuu.l.l...s.D.lA...cc..t...Ghs..u.lhl..hS..ssoVRpAhp-Alchschpppt....t..............	0	31	67	92
+6335	PF06507	Auxin_resp		Auxin response factor	Studholme D	anon	Pfam-B_2015 (release 9.0)	Family	A conserved region of auxin-responsive transcription factors.	21.10	21.10	21.70	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.66	0.72	-4.12	32	687	2009-01-15 18:05:59	2003-07-15 18:33:44	8	14	62	0	312	710	0	77.80	45	10.75	CHANGED	AupuhsstohFplhYpPRsosS-FlVshp+ahcuhp.p.aslGMRFKMtFEsEDusc++a...tGslsGls-hDPh+WssScWRsLp	...........................Au+AsussohFplaYpP....R........s.S.s.uEFllshs+ahc.uht..ppholGMRF+M..t.F.Es...E-.u.uc..+...........Ra..........hGTIsGlsD...h...D.P.h+WssScWRsLp..........................	0	40	196	261
+6336	PF06508	QueC	ExsB;	Queuosine biosynthesis protein QueC	Studholme D, Eberhardt R	anon	Pfam-B_715 (release 9.0)	Domain	This family of proteins participate in the biosynthesis of 7-carboxy-7-deazaguanine. They catalyse the conversion of 7-deaza-7-carboxyguanine to preQ0 [1-3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.56	0.70	-5.05	33	3226	2012-10-02 18:00:56	2003-07-15 18:54:36	8	14	2983	7	768	3867	2443	199.30	40	86.40	CHANGED	+AlVlhSGG.DSTTsLhhApcph..hEVhsloFsYGQR.HptEl-sAcclucths.........l.c+cllDlshLpplu...sSuLTcssht.lsc....ph.t.....cslPsTaVPuRNhlFLSlAuuaA-slGupsIhhGVsppDaSGYPDCRsEFlcuhppslsLu......tsptlpI.psPLh.LsKu-IhcLutcLG......lshchThSCYpG......tcu.uCGcCsuChLRpcGapchs	........................................................................................................................................+AlVlaSGG.D.ST....T....C.L....h..h....A....h......p...p..a.......p..c....V..p.......sl..o....F.....s...Y....G...Q...R.....Hc..........t.......E...l...-...s.........A....c...p...l.....Apc.l.G.............l........p....H..+..l.....l....D..l..s....h...L.....s.p.....l.u...........s.suL.....T.c....cs.h.t...lsp...............tt.................ssl..P.s.Ta....V.P..u.RNhl...F....LohA.u.sh......A....ph....su...c......t......l...h..h...G.....V....s...p.....s..D.....a..S........G........Y...P.......D..C..R.....sp.......F..l....c..uh...p...t.sl.s.Lu............hspsh..p.l...cTPL..ha..l.sKA-hh...tLu.p...p.h.G..............hsh.pp...ThoC..YpG....................utuCGcCsuCpLRtpGhpphh....................................................................................................................................................	0	218	457	625
+6338	PF06510	DUF1102		Protein of unknown function (DUF1102)	Moxon SJ	anon	Pfam-B_16043 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	22.20	22.20	22.60	24.40	21.70	22.10	hmmbuild  --amino -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.95	0.71	-4.39	9	41	2009-01-15 18:05:59	2003-07-16 09:38:25	6	2	17	0	35	48	0	144.00	39	74.21	CHANGED	sIVoDDsELIDLTPlQPYuYl..ssGKLslDISssNP.NYPGY.GcGlSPsSpYsF-EhFsVSNcLWEs...shPIsVpIp.Spsstlphauu-h-s..ussG..........sslsFoVthsssVslGM.Fsssscs.G.s.ptplsIcAhthusE	......................sIVsDDsELIDL.sPlQPYAYl..ssGcLsIDlSssNP.NY.P.G...............Y............GpGlSPsSpYsF-EVFpVSNcLWEs............h.sI.....sVpIs.Ss...ssplphausshss..ssss...........sslsFsl..G-sVplGM.hsssGt.s.G.shptplsIpAhthtsp................................................	0	5	14	25
+6339	PF06511	IpaD		Invasion plasmid antigen IpaD	Moxon SJ	anon	Pfam-B_16150 (release 10.0)	Family	This family consists of several invasion plasmid antigen IpaD proteins. Entry of Shigella flexneri into epithelial cells and lysis of the phagosome involve the IpaB, IpaC, and IpaD proteins, which are secreted by type III secretion machinery.	25.00	25.00	26.00	25.60	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.21	0.70	-5.44	3	264	2009-01-15 18:05:59	2003-07-16 15:13:00	6	2	198	33	19	191	0	261.50	40	88.15	CHANGED	tNhouSssPulsAuRupssosGpuAEpVpAsVcoTTu..........a-TpcsIppSsAAhKtppuQQTLpcTPstEl-EsssppTluspphsusLNuLAKSGaulSAEQ+EsL+Ssh.....SAPspAchuGuPM.....AtstpsISDuELWDMISssIucIsDsYLGVYENVVusYTDFYQAFSDILSpMAGWISPGG.DGNoVKLNVDSLKuALooLKKcYo......NKcslLFPAQo.suGhpTuSEuEAcKWlKELGLPD......SCV.KAusGGYVVlVDMTPIssMlsDLsuLGSGoELELDNAKYQAWQSGFKAQEENLKNTLQTLTQKYSNANSLFDNLVKVLSSTISSCLETAKSFL	......................................................................................................................................................................................................h...p..tp.Lshlu+..pt..s..lstptp.p..Lp..............SAPp...p.s..hss..h..............lSctElWshlupsIssIs-..sYLtVYEslVusYTpaYQsFS.-.lLSp.h.uGWloPGc.DGNolKLs.VsSLKstlppL..lsKYs...............sp.La.....Pups.......h....s..sopt-A..p.pWlpELshs...............upl.ptpsuG......YVV......hlshs...PlppMlpsl....sul......G...u...s.......u....t..l........hss...Ac.YQAWpuuFpuQc-NhpsslQoLspKYSpANShaDNLlKVLSusISo.h-oAKsaL................................	0	3	6	11
+6340	PF06512	Na_trans_assoc		Sodium ion transport-associated	Vella Briffa B	anon	Pfam-B_16808 (release 10.0)	Family	Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of Pfam:PF00520 and, less often, one copy of Pfam:PF00612.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.87	0.70	-4.39	62	1005	2009-01-15 18:05:59	2003-07-16 16:03:13	8	31	158	0	361	1059	0	206.90	31	13.21	CHANGED	DsEhNNLQlAlsRIpRuhsalKpsltshhp.thht+h....pphst...........................cttsp.hph.hsphhtst...................pth.t........h.tsuhpph.....pppp.tshhh...Nsshsl........sVPI..........AssESDh-......p............---tsSppS..................................t--scc......chpt.....................sSpSEsSTlDhcss.....tEt............-th..sc.t--.h-....P-cCFs-sCh++aPsht.lDhspshhphWWsLR+TCapIVEHsaFETFIIFMI	..........................................................................................................................................................................................................................................DsEhNNLQlAlsRIp+ulsalKpplh....phhp....thht.p.p......tthtt.......................................p..pp..p...htp...h.tst..................................................p.ptt..................tht.suhp..t.h...................pp.p..hshht.....ssshsl....................sVPI..........A.suESDhEs.p......................................s--hsSpss............................................................................................................-tspp...............................................................ssSsS-......sSTl..Dht.s...t-..................................................................p.h......-.tp....-.........P-sCFs.-.............sC....h...........p......+a...C..tp.ls..h.ppuhG+.hWWsLR+TCapIVEHsWFEoFIlFMI.......................................................	0	36	56	189
+6341	PF06513	DUF1103		Repeat of unknown function (DUF1103)	Moxon SJ	anon	Pfam-B_16075 (release 10.0)	Repeat	This family consists of several repeats of around 30 residues in length which are found specifically in mature-parasite-infected erythrocyte surface antigen proteins from Plasmodium falciparum. This family often found in conjunction with Pfam:PF00226.	25.20	25.20	26.50	25.30	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.38	0.70	-4.94	2	22	2009-01-15 18:05:59	2003-07-16 16:04:55	6	6	2	0	3	23	1	120.30	56	36.58	CHANGED	KVLGEGDKEDVKEKNDGKKDKVIGSEKTQKEIKEKVEKRVKcKCKKKVKKGIKENDTEGNDKVKGPEIIIEEVKEEIKKQVEDGIKENDTEGNDKVKGPEIITEEVKEEIKKQVE-GIKENDTEGNDKVKG.EIITEEVKEEIKKQVEEGIKENDTEupDKlhG.EIITEEVK........EGlKENDTEsKDKVIGQEIITEEVKKEIEpQEEK	..........................................................................................................................................cl.....-p.pc...........hcc..pc..slKEpDTEsKDKVIGQEIIhEEVKcEh.....ctl+c.....NcsEsKDcVIsQEIlsE-Vpct.......t........	0	3	3	3
+6342	PF06514	PsbU		Photosystem II 12 kDa extrinsic protein (PsbU)	Moxon SJ, Bateman A	anon	Pfam-B_13782 (release 10.0)	Family	This family consists of several photosystem II 12 kDa extrinsic protein (PsbU) proteins from cyanobacteria and algae. PsbU is an extrinsic protein of the photosystem II complex of cyanobacteria and red algae. PsbU is known to stabilise the oxygen-evolving machinery of the photosystem II complex against heat-induced inactivation [1]. This family appears to be related to the Helix-hairpin-helix domain.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.15	0.72	-4.14	24	89	2012-10-03 02:11:09	2003-07-16 16:26:02	6	2	78	17	32	170	35	91.40	44	59.54	CHANGED	stsDtchst.hG..pKlDLNNusVRsFpphPGMYPTlAuKIlpsuP...YcsV-DlLslssLo-cQKpllccah-sFsVscPpssh.tG.DRlNsGlY	................sDtKlsschG...pKlDLNNuslRsFpphPGhYP............oLAuKIl....p....s...u...P....YcsV-DVLslsGLo-pQKpllcp.hc..pFsVTsPp.th..pG.DRlNsGhY..........................	0	10	23	30
+6343	PF06515	BDV_P10		Borna disease virus P10 protein	Moxon SJ	anon	Pfam-B_16237 (release 10.0)	Family	This family consists of several Borna disease virus P10 (or X) proteins. Borna disease virus (BDV) is unique among the non-segmented negative-strand RNA viruses of animals and man because it transcribes and replicates its genome in the nucleus of the infected cell. It has been suggested that the p10 protein plays a role in viral RNA synthesis or ribonucleoprotein transport [1].	25.00	25.00	27.40	61.40	23.90	17.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-9.98	0.72	-4.15	3	40	2009-09-11 07:51:39	2003-07-16 16:31:46	6	1	7	0	0	39	0	81.20	67	99.97	CHANGED	MSSDLRLTLLELVRRLNGNATIESGRLPGGRRRSPDTTTGTVGVTKTTEDPKECTDPTSRPAPEGPQEEPLHDLRPRPANRKGAAIE	...MSSDLcLTLLELlRRLNGsuTlESGRLsGGRRRSPDTTTGoIGVTKTpEssKEChDPTuRsAPcusQEEPhHDLRPRstsRKGAslE	0	0	0	0
+6344	PF06516	NUP		Purine nucleoside permease (NUP)	Moxon SJ	anon	Pfam-B_15961 (release 10.0)	Family	This family consists of several purine nucleoside permease from both bacteria and fungi [1].	21.10	21.10	21.10	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.80	0.70	-5.60	31	328	2012-10-01 20:25:13	2003-07-16 16:35:58	6	4	268	0	136	310	52	309.80	42	85.63	CHANGED	lssKVhIloMFE.........sEhpsWh-t.....sh.........s+sIslPGhs..assl+Cssc.ulCtlsTG.GphNAAuolsALshsspFDLo+TYaLlAGIAGlsPptuTlGSssWA+YsVpssLpaEIDsREl.....PssWsoGYhshsspp..PsphPsssYs..........TEVFpLNstLpshAhpLo+ssp..LsD.ossspshRtpYssts........AppsPtVlpsDshoucsaapGshLs-hhpsasclhTsGsGsYsoTupEDsAThcALtRhupsGhlDhsRlhlLRTuSNFspPssGto..uhcpLhpts....tGGhssAl-NlYpsGsslVcsIlspWsp.acsGlss	...................................ssKVhlloMFt............sEupsWl-p........hth.........scp.l.slPGLSs.YPslcCssp.slChlsTGhG.sNAAuolhALshSs+FDLp+T..........YFLlAGIAG.l-PppGTlGSAsWA.+.YsV-huLpa..-l...DsR.Eh.....Pt....sW..s.sGah..u...lss.......p.p..Ps..ppPs..h.s.at...............TEVFpLNspLtshAhuLo+s.lp..LtD.ospupAhRt+Ystts..........AspsPpVhpCDThousTaapGshLu-thpsWoKlhTcGpGsYCoTtpEDNAThpALpRuApsu+lDhsRlhlLRTuSsFDRP.hsGpo..uh-sLhshs.......GGFs.Ah-NhYpsGsslVpsIlspWsp.acpul.s...........................................................................	0	35	73	113
+6345	PF06517	Orthopox_A43R		Orthopoxvirus A43R protein	Moxon SJ	anon	Pfam-B_16577 (release 10.0)	Family	This family consists of several Orthopoxvirus A43R proteins. The function of this family is unknown.	20.90	20.90	21.70	53.10	18.20	20.10	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.45	0.71	-4.75	2	47	2009-01-15 18:05:59	2003-07-16 16:39:31	6	1	19	0	0	35	0	194.30	91	99.60	CHANGED	MMhKW.ISILThSIhPVLuYoSSIFRhH.sp-lELCYG+L.FD+l.N.VNIKY.P.aIPYRYNFINpTLTVDEhcc.NVhFT+u.FLKa+YuS.LssuLlVuLuspLKYNDlpC.VNVSChIKNLhTpTSTILTSKHhTYSL+RSpC.hIIGYDSIIWYKD.IsD+......YNGIYDFTAICMLIASTlIVhlYhhK+IKMN.	......MMMKWIISILTMSIMPVLAYSSSIFRFH..SEDVELCYGpLYFDRIYN.VVNIKY.P..HIPYRYNFINRThoVDELDD.NVFFTHGYFLKHKYGS.LNPSLIVSLSGNLKYNDIQCSVNVSCLIKNLATSTSTILTS.KHKTYSL.HRSpCIsIIGYDSIIWYKD.INDK......YNDIYDFTAICMLIASTLIVTIYVFKKIKMNS.......	1	0	0	0
+6346	PF06518	DUF1104		Protein of unknown function (DUF1104)	Moxon SJ	anon	Pfam-B_16082 (release 10.0)	Family	This family consists of several hypothetical proteins of unknown function which appear to be found largely in Helicobacter pylori.	25.00	25.00	27.50	28.70	24.80	24.10	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.06	0.72	-3.85	12	166	2009-01-15 18:05:59	2003-07-16 16:41:54	6	1	63	1	18	153	0	89.50	44	61.91	CHANGED	ADFSKposcELhphuuslssp-hsDhthElcKRhtchpht-u+pa+pph+pthpcphsphohc-tpca+ptl+cthpc.+l-shSscEtcchGl	....pDFSphsDc-LlchAGpV.ssp-llDY+hElpKRhctMst--pK.p.F+tph+chAcKNlupMS.cDac+h+c-l+cslcc.+hKsho.cEh+t.GL...............	0	4	10	18
+6347	PF06519	TolA		TolA C-terminal	Moxon SJ	anon	Pfam-B_16081 (release 10.0)	Family	This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function.  Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See Pfam:PF01024).  TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.19	0.72	-4.01	9	916	2012-10-03 21:09:15	2003-07-17 14:43:38	6	1	772	6	109	684	85	92.70	45	28.50	CHANGED	ssstpuGssGs-lspYuu.IpptIQp+hhcsssatGKsCslcI+LuPDGh...lhslps.uGDsslCpAAluA.A+ssKlPhsPos.sVYEphKshsLsh	....................................sstpsussu.u-l.ssYAupIpsAI..p..u....+....h.h.-....s....s.s.a.t.....G.K...p..CsL..+I+..L..A..PD.Gh....L..l....s...l...p...s..c....G...G...DP..A....LCpAAluA...AKhAK....lP..+P..P....Sp..sVYEh.aKsusLcF....................	0	13	34	72
+6349	PF06521	PAR1		PAR1 protein	Moxon SJ	anon	Pfam-B_16232 (release 10.0)	Family	This family consists of several plant specific PAR1 proteins from Nicotiana tabacum and Arabidopsis thaliana. The function of this family is unknown.	25.00	25.00	26.00	64.70	22.40	20.90	hmmbuild  --amino -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.18	0.71	-4.65	4	68	2009-09-11 00:11:32	2003-07-17 16:32:16	6	1	14	0	38	70	0	144.60	49	87.47	CHANGED	sIsCENLscsoCuFAISSoGKRCVLEKph+RSGEEsYTCRTSEIEA-KlpNaIETDECIpACGVDRpsLGISSDuLLEupFTpKLCSstChcaCPNIVDLYFNLAAGEGVYLP+LC-pQtGpuRRuMuEI+SSGl...............lAPuPtSpl...cssNhhhsPAhuPh	...lhCEpLst-sCAFuVSSSGpRCVLE+thhpsGpht.YpCpTSElh.s-..+.lppaIETDpClcACGVDRtoVG..I..SSDuLh.Es..pFopKLCSspCappCPNIVDLYhNLAAGEGlaLPcLCpspcsss.RRt.h.h-...hhSsu................hAsts....................................................................	0	3	32	35
+6350	PF06522	B12D		NADH-ubiquinone reductase complex 1 MLRQ subunit	Moxon SJ	anon	Pfam-B_16238 (release 10.0)	Family	The MLRQ subunit of mitochondrial NADH-ubiquinone reductase complex I is nuclear [1] and is found in plants [2], insects, fungi and higher metazoans [3]. It appears to act within the membrane and, in mammals, is highly expressed in muscle and neural tissue, indicative of a role in ATP generation [3].	21.50	21.50	21.50	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.32	0.72	-4.28	55	447	2009-01-15 18:05:59	2003-07-17 16:38:21	6	4	210	0	280	434	1	69.80	27	72.13	CHANGED	hp+P.plhPLhsslususshssh.lsR.hhtNP-VphsKcsp...........s-.hpcas.pp.pKahpspt.......-hhshhppt.sch	....................hcP.plhPLhs...hlususshAshhhhRhhhtsP-Vp.hs+psp....................s-shpcht.pt.hKhht.p........ph....p.............................................	0	82	142	207
+6351	PF06523	DUF1106		Protein of unknown function (DUF1106)	Moxon SJ	anon	Pfam-B_16281 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins found in Escherichia coli and Citrobacter rodentium. The function of this family is unknown.	21.10	21.10	21.10	80.30	21.00	17.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.02	0.72	-4.16	2	25	2009-09-10 17:00:18	2003-07-17 16:40:58	6	1	18	0	1	16	0	89.10	89	70.05	CHANGED	MASLWK+LFY.sGpRRRYFEptEHSFSIlCGRLRGIVlThKCSpGIIYLSIKVsPNNppHlhLYpKK-YlFDKLKElFPDEAIEFoIEYEN	MASLWKRLFYSSGRRRRYFEEGEHSFSILCGRLRGIVLTIKCSNGIIYLSIKVSPNNRNHVFLYHKKDYVFDKLKEIFPDEAIEFTIEYEN	0	0	0	1
+6352	PF06524	NOA36		NOA36 protein	Moxon SJ	anon	Pfam-B_16330 (release 10.0)	Family	This family consists of several NOA36 proteins which contain 29 highly conserved cysteine residues. The function of this protein is unknown.	25.00	25.00	39.60	39.50	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.43	0.70	-5.17	3	242	2009-01-15 18:05:59	2003-07-17 16:49:12	7	2	207	0	71	226	0	192.60	70	97.66	CHANGED	MPKKKTGsRKKAEKQRERcKEIRuS..sVDLA+HPCNAsMECDKCpR+QKoRAFCYFCNSVQKLPICAQCGKpKCMMKoGDCVlKHAGVYoTGLuMVGAICDFCEAWVCHGRKCLoTHACsCPLpsApClECERGVWEHGGRIFpCSFCpsFLCEDDQFEHQASCQVLEuENFKChSCNRLGQYSCLRCKsCaC-DHVRRKGFKYDKs.KslPCPKCGY-ToETKDLSMSTRSaKFGRQTpGtcS.DD-pGYGuYapNhuSscYGDstussYGYcuDDDE--.SusDYDEEpDtDDDDsE-sD-..TopNcG-c-sDstA	................................................................................p..+..+QKsRAFCYFCpulQRLPhCApC..GKsKCMhKo.GDCVlKHsGVaoTG...............L.uMVGAICDFCEAWVCHGRKCLooHACoCPLtDA........sClECERGVW-HGGRlF+CuFCpsFL...............................................................................................................................................................................................................................................................	0	24	28	49
+6353	PF06525	SoxE		Sulfocyanin (SoxE)	Moxon SJ	anon	Pfam-B_16349 (release 10.0)	Family	This family consists of several archaeal sulfocyanin (or blue copper protein) sequences from a number of Sulfolobus species.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.56	0.71	-5.03	6	66	2012-10-02 17:41:00	2003-07-17 16:56:28	6	2	39	0	29	130	19	176.80	30	82.35	CHANGED	IssllVlIlllGlulY............................s.sphshlSosooosoToooos...............PutlsLPYsSsNKTVFIhLsVpoous..tFNaNGTSsGphKIYIPAGWsVhVpFhNpESLPHNLslVQNsTshPNssslSuDGKIlhhVGsosSNYtssGISSGpoAsGlhssluAGhYWlACGIsGHAcSGMWssLlVSsNVTsPYslh	..........................................................................................................llhllhhuh.hh...............................s..t.p..o.s..sosps.os.tsot..................................sst.....hs.sss...p.+TV.lhlh.shss.us........hNasGoup...G....ph.....plhl..PA......GhsV......hlphhN.p.p.u.l..s.....Hshhl..l....s...s..s.t.h.P...s.....ss...slu.t...G+..I.....l.h..h.l.Gs...o.s...us..h..s...p.G.l....u.........Gpss...s.s.h...h.....sls...AGhYhlsCsIs.GHAtsGMWs.llVSsshp.P....t..........................................................................	0	7	14	26
+6354	PF06526	DUF1107		Protein of unknown function (DUF1107)	Moxon SJ	anon	Pfam-B_16434 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	25.00	25.00	47.30	47.20	19.90	16.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.83	0.72	-4.16	21	718	2009-01-15 18:05:59	2003-07-17 16:58:32	7	1	677	1	82	194	5	63.70	70	91.41	CHANGED	hRhFcpYpPpplA+aVKsLF+GplaIpGlGtFcFDpG+lLl..Ppps-ppphpshpEVNppIppLp	.MKIFQRYNPLQVAKYVKILFRGRLYIKDVGAFEFDKGKILI..PKV+DKhHLSVMSEVNRQVMRLQ...	0	6	23	51
+6355	PF06527	TniQ		TniQ	Moxon SJ	anon	Pfam-B_16755 (release 10.0)	Family	This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons [1].	25.10	25.10	25.10	25.10	24.90	25.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.10	0.71	-3.96	43	576	2009-01-15 18:05:59	2003-07-17 17:04:04	6	10	398	0	177	503	23	138.90	19	29.75	CHANGED	hLshp.lsh.hssEshsSahuRLAttp..shssh...................psahtc.hG..hshpslhpsp........sslstlAphuGhss...spLtthsh.................................spstspt....hpl..tuchlspphl...ptsp.hRhCPtCL.tpDhtt.......stttshhRhtWplsslpsCspHpshL	......................................................................................................................hh....h.sEsltSaltRhAhtp.......thts.h.............................t.phhtp.....hs......hs...ht..t.hhtst................t.ltt.l..u..t....h.....s..s.h.s.s.....spL.p.ph..sh.......................................hphtpt...............hph.......htth.h.sp..phh...........t.t...h+....h....CPhCL...............ptsah+.htWpl..s..hht.sCspHpshL...................................................................................................................................	0	27	90	129
+6356	PF06528	Phage_P2_GpE		Phage P2 GpE	Moxon SJ	anon	Pfam-B_15359 (release 10.0)	Family	This family consists of several phage and bacterial proteins which are closely related to the GpE tail protein from Phage P2.	20.90	20.90	20.90	22.30	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.97	0.72	-4.51	17	525	2009-01-15 18:05:59	2003-07-17 17:09:05	7	2	406	0	55	217	1	39.10	54	85.46	CHANGED	MADIAslFHWsPu-htsMoLsELhcWRE+AhhRSG.sss-	...MADIAsIFHWsPu-h.sMolsEllsWR-+..AhtRSGsscp.........	0	7	24	42
+6357	PF06529	Vert_IL3-reg_TF		Vertebrate interleukin-3 regulated transcription factor	Vella Briffa B	anon	Pfam-B_16154 (release 10.0)	Family	This family includes vertebrate transcription factors, some of which are regulated by IL-3/adenovirus E4 promoter binding protein [1]. Others were found to strongly repress transcription in a DNA-binding-site-dependent manner [2].	25.00	25.00	84.80	69.30	22.60	20.10	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.06	0.70	-5.47	2	48	2009-01-15 18:05:59	2003-07-17 17:13:27	6	2	37	0	24	43	0	293.00	70	72.99	CHANGED	SSsuYAQEIQKLSsSTsVYFQDYQoSKsslsSFVDEHEPuhVuuSCISVIKHSPQSShSDhSEhsSVEHTQtS.hQusCRSPENKF.lIKQEPlELE...REsR--RGoYpsSIY.sYMGooFshYSHSPPLLQVptSoSNSPRTSEsD-GVVGKSSDGEDEQQVPKGPIHSPVEhppVHAT.VKVPEVNsSALPHKLRIKAKAMQVKVEAhDs-a-uhQKLSSPhDh.uKRHF-LEKHGspshsHSShsPFSVQVTNIQDWSLKsEhWHpKELssKhQsuhKTGVVElKDssYpVSEuENLYLKQGIANLSAEVsSLKRhIsTQ.ISASDSt	......................................SSsAYAQEIQKLSsSTAVYFQDYpoSKus.h.suFlDEHEPohVuSSCISVIKHSPQSSLSDlSEsS.SlEHoQtS..shQusCRSPEsKFQhIKQEPhELEsasREsRDDRGoYpuSIYQNYhGsoF.s.GYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPVELKpVHATlVKVPEVNS..SALPHKLRIKAKAMQIKVEAhDsEa-uTQKLSSPlDMouKRHF-LEKHsssshVHSS.LoPFSVQVTNIQDWSLKsEHWH.pKE...LsuKhQsuh........KT.GV..........VEhKDsuYpVS-sENLYLKQGIANLSAEVsSLKR.LIsTQ.ISASDS....	0	1	3	6
+6358	PF06530	Phage_antitermQ		Phage antitermination protein Q	Moxon SJ	anon	Pfam-B_3979 (release 10.0)	Family	This family consists of several phage antitermination protein Q and related bacterial sequences. Antiterminator proteins control gene expression by recognising control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream [1].  	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.71	0.71	-4.56	4	887	2012-10-04 14:01:12	2003-07-17 17:17:27	7	1	490	0	56	475	2	118.00	44	91.35	CHANGED	hRDIp.V..........LERWGAWAtssptslpaSPIAAGF.KullPh+spsRP.CsDDDGhIIssshspLpp.psschhsLLlsYYl+G.St+AIA++pthScspItK+Lp+AEGhI-GsLSlhsVRL-hDthlctt	...................................................hRDIp.V..........LERWGAWAs..s...s.p...p.c.lsa.Ss......IAAGF.....KG.L.l.....P.....p...+....s.K..o.R..P.p.C..s.DDD...uh.l.IsuChAR.L.p.+....psp...ch.a-....LLlsY....YV.h.GhohhulAc+......+.....psS-.shItK..cLp+AEGhl-G.hL.hhLsl+LEMD..h..p......................................	0	7	18	33
+6359	PF06531	DUF1108		Protein of unknown function (DUF1108)	Moxon SJ	anon	Pfam-B_16830 (release 10.0)	Family	This family consists of several bacterial proteins from Staphylococcus aureus as well as a number of phage proteins. The function of this family is unknown.	25.00	25.00	32.70	32.70	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.83	0.72	-3.83	4	313	2009-01-15 18:05:59	2003-07-18 11:23:49	6	1	192	0	4	97	0	84.90	65	99.43	CHANGED	MYYKIG-lppKlIsVsGFDFKLtVhKpchuIpIpVhDhpsssIcuhhVsDENDLYhAhDlhpQuI.EWIEpNTDEQD+LINLVM+W	.MYYchG-lppKlIsVsGFDFKLtlhKpchuIpIpVhDhpsssIcuhhVsDENDLYhAhDlhpQuI.EWIEENTDEQDRLINLVMKW....	0	2	2	4
+6360	PF06532	DUF1109		Protein of unknown function (DUF1109)	Moxon SJ	anon	Pfam-B_17952 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.60	21.60	21.90	21.90	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.82	0.71	-11.38	0.71	-4.90	54	293	2009-01-15 18:05:59	2003-07-18 11:29:26	6	3	227	0	122	289	32	192.70	31	93.87	CHANGED	LusshpPlpthshspphuhuhhsuhssuhllhhhh..hGlRsDlspshtsshFahKhuhshsLulsAhhssh+LuRPs.uptttthhhlslshshlhlsuhhplhss.sssthh.shlhGpshh..hChhsIsllulPshsuhhhulRp.hAPoc.thAGAsuGLsAGuluAhsYuhaCs-sussFlulWYsluhhlsuhlGAllGsRlLRW	.............................................LssphpPVpphshtphhhhshlhuhs..sussl.hhh..h..h.G.h.R.s...Dlsts.h.t.s.shF......hhKhshs..hhlussuhhshhtLuRPt..ptshh.hh.hl.sls..hsslhh.uuhhphhts....sst.sh..shlhG.tshh.......hC.hhIsllSlPsh.suhl.hulRp.hAPs+PslAGhsAGLsuGuhushl.Yu.haCs-suhsFlulWYslulshssslGAlhG.hhLRW.........................	0	29	59	86
+6361	PF06533	DUF1110		Protein of unknown function (DUF1110)	Moxon SJ	anon	Pfam-B_18243 (release 10.0)	Family	This family consists of hypothetical proteins specific to Oryza sativa. One sequence (Swiss:Q943P1) appears to be tandemly repeated.	24.10	24.10	24.20	24.40	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.21	0.71	-4.48	6	38	2009-01-15 18:05:59	2003-07-18 11:34:57	7	3	6	0	21	23	0	156.90	35	84.03	CHANGED	MAAE..AWRuRFRcRVsEAAp...RhEsVcEsLAsAhsHL...susMlAuD..tAAAARsRIQLAhGtLt-ASpsLA.AMSlMpuAcLLsh+.Gs.hs..h.httIupLGDp....YLAE+sAshKL+tAtcDAc-AastVDtCRGHLDAlLLLLDH.s+LPuVsshI-pERh.AAsuDLpAAIGpschGsEhAVsARQDVSG	...............c...sW+shF.pRVs.sst...phctlpt.Ltss..tl.....s.h.s..........Asssts+h....ttL.pASppLu.AhuhMtuAcLLAh+..Gsu.....sstt.hs....slspL....sDp....hh....s.ppAhh+LptAtpcAccAastl-tCRGHLsAlhhLLc+....thssVpshlptEhh.sAss.LpsA.............................................................	0	0	1	13
+6362	PF06534	RGM_C		Repulsive guidance molecule (RGM) C-terminus	Moxon SJ	anon	Pfam-B_18263 (release 10.0)	Family	This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum [1].	21.60	21.60	21.60	21.60	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.40	0.71	-5.09	23	234	2009-01-15 18:05:59	2003-07-18 12:07:50	8	6	64	0	115	193	1	170.90	49	43.56	CHANGED	Cs-QKlYpApoD-..LPuAFsDGopsGG-............psspoL...........cIhEpssG...pHVEIpA+YIGTTIlVRQlGpYLThAlRhPE-lspshp.-ppDlp..LClpGCPtsppIDhpphhtps.....................t.st......shshc....sAps+C+-p........hsVpDhYFpSCVFDLLTTGD...ssFThAAhsAhcDsctLcPspp..+h+l	.................CsDQKVYQApsD-..LPAAFsDGSpsGGD...........ttsusSL...........pIsE+ssG...pHVEIpA+YIGTTIlVRQlG+YLTFAlRMPE-lspuh-...-ppsLp......LClpGCPhsppI-hpthptps.......................s......s..sash-....oAps+C+Ep........LPVEDlYFQSCVFDLLTTGD...sNFThAAasAL.EDl+hL+sspc+hH...........................................................	1	17	28	67
+6363	PF06535	RGM_N		Repulsive guidance molecule (RGM) N-terminus	Moxon SJ	anon	Pfam-B_18263 (release 10.0)	Family	This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum [1].	24.00	24.00	24.30	24.00	21.50	23.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.31	0.71	-4.23	14	210	2009-01-15 18:05:59	2003-07-18 12:35:16	7	4	61	0	111	164	0	164.30	57	41.22	CHANGED	C+lp.+Csupaspsp.p.s..htt................sstaCpuLRsYshChpRTARsCRGs..LsYHSulptlpcLhppaNCScsusTsps....................s.tsss.csCsY....................sp......apaCGLFGDPHLRTFpccFQTC+VpGAWPLIDNpYLsVQVTNsPVs.GSs....ATAToKlTlIhKs	...............................................C+I..+Csu-ahusTut.ps.hh.s.s......................ss-aCpALRuYAhCT+RT.A.RsCR.Gc..LsYHSAVhGIcDLMsQ+NCS+-GPTSps.......................................s..ptpsss-.C..pYcpp.......................httcsssPs......YhHCGLFGDPHLRTFpDcFQTCK......VpGAWPLIDNsYLsVQVTNsPV.lsGSu....ATATsK...lTIIFKs.......	0	14	25	63
+6364	PF06536	Av_adeno_fibre		Avian adenovirus fibre	Vella Briffa B	anon	Pfam-B_16053 (release 10.0)	Family	This family contains avian adenovirus fibre proteins, which have been linked to variations in virulence [1]. Avian adenoviruses possess penton capsomers that consist of a pentameric base associated with two fibres [2].	24.90	24.90	25.00	82.70	18.50	24.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.38	0.72	-4.29	6	42	2009-01-15 18:05:59	2003-07-18 14:02:22	6	1	6	6	0	36	0	96.10	66	20.54	CHANGED	YhsSGsusLppaTA+u.NSSs.uFsCAYYLQQW.opGLlhoSLYLKLDpsphushPostsspNA+aFTFWVuua.pphN.StIpssTloPSTsphss	TFVSGSsSLsoYNAshVNSSupsFSCAYYLQQWNlQGLLhTSLYLKLDSsTMGsRPGDhsSsNAKWFTFWVSAYLQQCNPSGIQAGTVSPSTATLo...........	0	0	0	0
+6365	PF06537	DUF1111		Protein of unknown function (DUF1111)	Moxon SJ	anon	Pfam-B_16636 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	499	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.50	0.70	-6.22	6	817	2012-10-03 10:02:11	2003-07-18 14:21:28	6	16	490	0	304	843	222	260.40	28	76.15	CHANGED	YTcloA.GGcTT.TFDASsSG.HGFSTPAsNLssspLA.HLpGDtpFETuFTTAPNuEH......PELDGLGPVFNNADCNSCHQRDGRNSTPpluuGpsRVKLGS-....AGIFLRIStAsspsChpG...oAsNNYCAPIsVPsFGuQLFH......RGVLpARsDWQpN.FhGQADVYLSYEhpoVoYs..........DGopVoLKKPlFpVENPYDAPGEoctSsNlTSsLLQsDVL......................MGWRNGMPVFGLGLLEAIuEAsILAhVDEsDoNpDGISGRANaVFDAlKAQuGDspPVSLGRFGWKANTPSVRVQSLGALRGDhGITNPLF..P-ESItGTuLHDSYLTRTGFVDTGss.sGtPEASAEFSDs....VVFYAETLAVPARRNVssspVREGA+LFsQlNCouCHsPoFsTKsSG-..lGGhPMs-uLKGQTIYPFoDMLLHDMGEGLADuRPDFLAoGsEWRTRPLWGIGLTQTVNPQAGFLHDGRAATLEEAILWHGGEAptSppsFMuLops-RuQLlsFLMSL	............................................................................t...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...............h.h..a.t.l...usP..t.c................t................h................t................t.....t.s......GtthF..p......htC..CHhsp.h.T......................................................................p............l.P.aoDhllHDhG........t..h..........sD...........t.............h..............p...................s.....p....ut...........a.RTsPLWG....hG....h..............................t.....................s...t...t....h.L.HDGRA.csh.EA..lhWH.......u.....G.............-ut......utp.h.t.hs.tpRttlltFlpu.......................................................................................	0	99	179	252
+6368	PF06540	GMAP		Galanin message associated peptide (GMAP)	Moxon SJ	anon	Pfam-B_16759 (release 10.0)	Family	This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown [1].	20.40	20.40	20.40	35.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.01	0.72	-4.25	6	53	2009-01-15 18:05:59	2003-07-18 14:33:41	6	4	37	0	24	47	0	56.90	53	47.48	CHANGED	GKRELpPE.--h+PGuhDRsluEsNlVRTIlEFLoFLHLKEAGALDpLPslP.AtSuEDspcS	...GKRELpsE.--h+sG....uhc.Rsls.-sNIVRTIIEFLoaLHLK.Es...GAL-pLP....sh..SsE-ht..................	1	1	3	7
+6369	PF06541	DUF1113		Protein of unknown function (DUF1113)	Moxon SJ	anon	Pfam-B_17933 (release 10.0)	Family	This family consists of several bacterial proteins of unknown function.	19.70	19.70	20.10	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.08	0.71	-4.47	52	996	2009-01-15 18:05:59	2003-07-18 14:35:25	6	5	523	0	214	836	24	148.40	27	59.94	CHANGED	hhhFhlYSFlGWlhEsl...asu.lpc..++al.NRGFLhGPhCPlYGhGulhll...hhLtthpp..........shhhlFlhuhllsoslEYlsuallEplFpt+.aWDYSchhhN.........lpGRlCLhhSlhWGlhullhlchlpPhltphlphlPhhht.hhlshllhlhhlhDhlholh	..........................................................hhFhlauhlGWhhEsh....a...ss....lpp.......tc.ah....tcGh..Lh.G.P....hs...P...lY.GhGslh..lh.......hh..lp.hpp.....................shhhl.alhu...hllso...slEYlouhhlEt...hF...p.hp...hWDYSs.h...hN.........lpG..p...lsL.hulhW.Glhull....h...lphlpPhl..ph.h.t...h.l....h.hh...hhshhhhhhhhhDhhhoh.h........................	2	87	144	175
+6370	PF06542	PHA-1	DUF1114; 	Regulator protein PHA-1	Vella Briffa B, Sammut SJ, Pollington J	anon	Pfam-B_16084 (release 10.0)	Family	This family represents the protein product of the gene pha-1 which coordinates with lin-35 Rb during animal development. The protein is expressed during embryonic development and functions in the cytoplasm. PHA-1 acts in a parallel pathway with UBC-18 to regulate the activity of a common cellular target [1].	21.50	21.50	23.00	22.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.75	0.70	-5.75	8	118	2009-01-15 18:05:59	2003-07-18 15:08:16	6	3	5	0	117	123	0	344.80	28	74.95	CHANGED	VN+oFNhullcpIRp-acpVll+s....hcp..Dhtpc.........pp.spulhlNsp+lphpphp...pahRFLKpss+I+Vp+lhlc-h.....cphshps-l..HpsIhcsLlsssh..pplcEFhGhssIC.pGChtCtcIutsCpsYGPlQhsh...hhttc+HF-tLpls-hhlthlh..........lps.p.s.......thh-phIssploCD+LplhLsshh..pthsh......lsR-llDhlltpWpVKoVcl........tah............hptphshlphppchhs..hpTpPtupa.sL-pV-Islphu...spshtp.h+ppt....Sl.sF-NhIuNV+RIFPTpclplcLPppl..h.hs.ssh-cFlpsllcMs.+-sp....RNS+Ish+La....sppl..ph...........lsshhpcspsh+...........................p.l..h..........p.ph.pupsaph	................................................lNKshN..hLphlRppapphplch..............................ps..hlaI..Nh++lp.ppl..........................sa...F...FLspsstV+V....cclhhcpl.......................t..htpph....HchIhppLIG.sst..................pplpplIGh-...-l.C..tG....C..pC....plApc..Ch.-.YGPlphps..hpphp..sppa+cLploDtLhcpIAp..........lppspppp......shppLsphIhs..sISCDpLslhl..s.E....p..h............pps..........................hPREVl-hll+KWsVKSlcl............phhpp............tWhphs...hFTplc...h.sc.......h........ppppsch....+hp+VpVsls.S..hsp.sh.hp....ht........ts.apNhIsNlRRhF.scplohp.hs+hh.....h...slcchhpsllphhph-pp....ppLpl.shpha................................................................................................hp....h....h........................................................................................................	0	15	16	117
+6371	PF06543	Lac_bphage_repr		Lactococcus bacteriophage repressor	Vella Briffa B	anon	Pfam-B_16088 (release 10.0)	Family	This family represents the C-terminus of Lactococcus bacteriophage repressor proteins.	20.10	20.10	20.10	20.40	19.50	20.00	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.43	0.72	-4.43	4	31	2009-09-11 15:56:52	2003-07-18 15:42:07	7	3	23	0	5	22	0	49.90	55	35.06	CHANGED	cpppcslDLADlV........DDsKVDWDcWVSFDG+PLoDEVKcAMKthhGKcLpD	.....ppEslDLAcLV........DDsK.VDWD+WVSFDG+PLTD-VKpAhKhlhGK+LpD...	0	2	2	4
+6372	PF06544	DUF1115		Protein of unknown function (DUF1115)	Vella Briffa B, Sammut SJ	anon	Pfam-B_16104 (release 10.0)	Family	This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.	27.60	27.60	27.80	27.80	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.61	0.71	-4.46	37	568	2009-01-15 18:05:59	2003-07-18 15:54:08	7	14	302	0	389	542	2	126.60	26	28.30	CHANGED	hhsa+I....ts.p+Rh+lhpsA+phpLoGhsl.hs..psullsVEGspcshccah+h.l++lpW......tt.tchptppppsp.h................................p...hhhps..tp+pF.pta.p.t..............s.s.sphhchLpc.......ps.stphaphsh	..............................................hsa+l...h.t.s.s..p+RhKlppsAppLtLTGhsl.h..........t......c......ss............lllVEG..spcu...hccat+Lhl+RlpW...................pp.ptppp-s.tp.t...........................................................h.hhhc..u..t.....p..pR..tF...ppa..p.p.................p.s.sthpchLpc........ps.hpchaphh....................................................	0	135	200	296
+6373	PF06545	DUF1116		Protein of unknown function (DUF1116)	Vella Briffa B	anon	Pfam-B_16143 (release 10.0)	Family	This family contains hypothetical bacterial proteins of unknown function.	20.10	20.10	21.00	20.50	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.28	0.70	-5.25	21	940	2009-01-15 18:05:59	2003-07-18 16:05:16	6	5	543	4	68	423	39	213.70	60	44.22	CHANGED	lphtPCHcasAVGPMAGlhSsSMPlalVcs.pstGscuassLNEGlG.KlLRaGAhsp-VlpRLcWhccsLuPsLppAlt.....tpGsl-LpslhApALpMGDEsHsRNtAuosLLl+pLsPhll....p.sshspppht-VhpFlussDtFFLNLsMAAsKshh-AAp...slssSolVTsMuRNGscFGIRluGh.GscWFTuPAssspGhhFsGaut-DAssDlGDSA	...........lsF.PCHchsAVGPMuGlTSASM.MhlVcN....tT.GNcAYsNhsEGlG.KVlRFGA.spsVlsRLpWMRDVLuPhLpsAlt.....httsIDLpsMhAQulpMGDEhHpRNhAuosLLhpALsPtIh.........p..hsasp.....pphtEVh-FlusoD.FFLslhMAhCKAAMDAut...tIctuolVTsMsRNGspFGlRVSGL.G.spWFTuPsp.p.s.pGhhF.sG.as.EDussDhGDSA...........................	1	30	46	57
+6374	PF06546	Vert_HS_TF		Vertebrate heat shock transcription factor	Vella Briffa B	anon	Pfam-B_16244 (release 10.0)	Family	This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress [1]. This C-terminal region is found with the N-terminal Pfam:PF00447, and may contain a three-stranded coiled-coil trimerisation domain and a CE2 regulatory region, the latter of which is  involved in sustained heat shock response [1].	20.50	20.50	21.00	20.70	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-12.22	0.70	-4.99	6	211	2009-01-15 18:05:59	2003-07-18 17:17:15	6	3	60	0	80	199	0	220.80	29	52.29	CHANGED	uaSuoshhuPDssspsGPIISDlT......ELspuSPssosssSl-sp...sS.PllhIKE.....EPsSPupSPc.sE..P.t.phssGssh.ssT.hSPsshls..SILpEs-Ps............................s.phCLSVACLDK..................................sELpDHLDoIDssL-sLQsMLSu+uFSlDoosLhDLFSsSlsh..sDhslPDhcsSLASIpchLSstc.....stspEupsupscosKQLlpYTA.PLhhh............suus-s.uSsDhPh.h.ELt-uShhop..t..E.PT.uLLs.p.pPhsc-PshS	............................................................................................................................sthht.ct..hpss.II.DlT.........................E..h...s.P....ss....sh......-..p.............t..P.lh..lhE.....................E.sss.....pu....sp.pp...........s................sps....sp....s.h...s.sss.ls..S.Lppp.psss...s.........................................hs..slshL..s+...............................................................................................................sEL.DaLDuhDssL-shQshLsuctaolDss.hL.hDlFssuh........h..............sshtu.pp.hhps.........h..p...s...p..p......s....sppLlpYT.u.P.hhh....................s.s.....ss...s-hPh.h.EL......tss.h..p..............Po.uhL..............t..................................................................	0	6	11	38
+6375	PF06547	DUF1117		Protein of unknown function (DUF1117)	Vella Briffa B	anon	Pfam-B_16251 (release 10.0)	Family	This family represents the C-terminus of a number of hypothetical plant proteins.	25.00	25.00	33.40	33.20	21.60	19.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-11.02	0.71	-3.99	7	55	2009-01-15 18:05:59	2003-07-21 17:18:57	7	5	15	0	37	55	0	107.60	53	28.91	CHANGED	sVG.LTIWRLPGGGFAVGRF..uGGpRuGERpLPVVYTEM.DGGhNss...suPRRISW....uSR.....ssRSpER.tG.ltRhFRNhhuhFuphpsupSsSut.tStssp..p.....pspp..olhSpSsRRR	..sVG.LTIWRLPGGGFAVGRF..uGGtRsuERc..L..PVVYTEM.DGGFNsu.........uuPRR..I.SW.....ssp............su+upps...tGhltRhFRNhFusFGR..hpsss.S.s.Sup..t.ut...........................................................	0	3	22	31
+6376	PF06548	Kinesin-related		Kinesin-related	Vella Briffa B	anon	Pfam-B_16517 (release 10.0)	Family	This family represents a region within kinesin-related proteins from higher plants. Many family members also contain the Pfam:PF00225 domain. Kinesins are ATP-driven microtubule motor proteins that produce directed force [1]. Some family members are associated with the phragmoplast, a structure composed mainly of microtubules that executes cytokinesis in higher plants [2].	24.00	24.00	24.60	24.40	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.78	0.70	-5.94	10	95	2012-10-05 12:31:09	2003-07-22 10:00:52	6	7	24	0	51	91	0	320.50	36	43.48	CHANGED	uPT-SLAASLQRGLcII-.HppssAsRRSoVuhSFcphshpPs.tsssKlsuuVQo.Pc-ptspt...s.hLCssC+pptsssus.p-.ssh.p..h..hsss.............KuspKVlttAl+REppLEphCs-QAuKIpQL.............oullsQh+csp..c.pp......spt...............lL+pt.p.scsEslppphEsKclpEEhc.shpph.h-luE+EsLLcEIp-LKsQLp...hssotoosphpuSLLthohQlRp......sh..ttsscstpcsL-cER.+WTEuEScWISLTEELRl-LEusRphAEKhchELcpEK+CoEELcDALpRAMhGHARhlEQYsELQEKYs-LLp+HRplh-GIsDVKKAAAKAGhKG.sGoRFAsALAAELSALRlEREKERchLKcENKuL+hQLRDTAEAVQAAGELLVRLREAEEAsolAcERsstsEpEs-KLKKQlEKLK+KH-pElsThKQ...hLAES+LP	.........................................................................t..p.pLAuSlp+Glplh-.apts..h.ppu.hthsht.ht.p.........phssth.................hh...sp......t................................................................pt...h.t.s..cph.hct.C.cQsscI.pL..............................................................................pth.pc......tph...hs-+E.L.tEItpL+tpLp.............p.t.t...........h....p.p.............................ps.....t......h.E.EScWlsLs--LRh-l-sp+.hhtc.p.ELp.EKhsstElp-AhphAh.GHuRhlEpYs-LpEha.tLhthHphh.tGlt-VKptAu+A.uh+G.tt.tFhtuhusElosl+hp..+E.......ppNctLp.QLpDTAEAVpAAGELLVRL+EAEcAhs.upcphh.hppEspchhpph-cLK++ac.Eh.shpphL.-uph...............	0	7	26	35
+6377	PF06549	DUF1118		Protein of unknown function (DUF1118)	Moxon SJ	anon	Pfam-B_17963 (release 10.0)	Family	This family consists of several hypothetical plant proteins of unknown function.	22.50	22.50	22.60	22.90	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.54	0.71	-3.95	5	63	2009-01-15 18:05:59	2003-07-22 11:33:40	7	3	28	0	33	64	1	105.80	48	53.76	CHANGED	+LEK+KVLSsVEKoGLLS+AEcLGlTLSSlE+LGLLSKAEDLGLLSLlENsAuhSPuALASlALPLLlAAIAAVVLVPDDSssLVAlQAVlAuALVlGGouLFVGSVVLuGLQESD	..................plEchKlLopsEKAGLLStAEchGloLSslE+.LGLLSKAE-L..GlLShs..ps.u....oPus..Lho..lA.LsLLlAussslhlVP-Dssh.VslQsV.lAhshslGuuuhasuSsllusLQpu........	0	13	24	29
+6378	PF06550	DUF1119		Protein of unknown function (DUF1119)	Moxon SJ	anon	Pfam-B_17985 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.18	0.70	-5.27	5	64	2012-10-02 13:41:03	2003-07-22 11:36:36	6	2	60	0	45	154	100	273.30	36	93.22	CHANGED	suLFVlVQlLALLLusPhpsuEhQ..AaEsPTpslNSIa.YIVhlLlFThFVLIsIK+cKKWlIptlIYlslVu.VlaYVFhlLLoll.slAGhlNllSlllAIuLshLLYtYPEWYVIDlAGshlAsGlSALaGISFGVlPAVVLLIlLAVYDAISVYKTKHMIoLAcGVMDL+LPILFVIPcspsYSFls-oF-su--tEA..........tssaFIGLGDAVMPSILVVSAAlFl-o..l.uGlpYssLsAMuGTLlGhlVLhhhVhRGRPpAGLPaLNoGAIAGFLIGsLhuGl	....................................................................h..hhlhlQlhALhLs.....shtt.sshp..shEsPpsssNslh.Ylshl.Llh.TuhhLhhh+..hshphllphll....hhshhh..hhhYVa..tsll.s...hh..............h...h..................hhuhlhu.l...u.ls.sh.L...h....h.YP.E....WYV.ID.hsGllhu..A.G.su.ulFGISh.u.ll.P....s.llLLslLAVYDAISVYtT....cH........MlsLAcG.....Vh.-h....+lPllhVlPpphsY..Sahc.....t.....s.....htt.tt.pt.t.t...........................................................tsAaFlGlGDslhPolLVs........SAsh..F.....h..s.s.....s......l.............h...l...s....l..P..u...L.s.AhlG...ol.hGh.h.l.L.h.h.h.V.h.+.G+spAGLPhLNuGAIhGallGslhs...........................................................................	0	10	37	42
+6379	PF06551	DUF1120		Protein of unknown function (DUF1120)	Moxon SJ	anon	Pfam-B_17948 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  --amino -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.42	0.71	-3.78	7	319	2012-10-02 17:35:21	2003-07-22 11:42:21	7	1	164	0	52	239	31	98.50	32	43.39	CHANGED	LKVTGplssuACTPpLoGGGsVDaGphpsssLpss....chspLGhKsholsIoCsusstlAhsupDsRtsT.......t..tsshsh....shs..Gtt..s.ssttFGLGpossGtKIGAau	.......LKVpGpls.suuCTsp..l.s.s.GG.llDaGpls...supL.ps.T......p.s.s.pL...u.p.+.s.hol.oIsC.s.u..sTh...luaossDNRssS.......................................GlG....................................................................................	1	7	17	40
+6380	PF06552	TOM20_plant		Plant specific mitochondrial import receptor subunit TOM20	Moxon SJ	anon	Pfam-B_17991 (release 10.0)	Family	This family consists of several plant specific mitochondrial import receptor subunit TOM20 (translocase of outer membrane 20 kDa subunit) proteins. Most mitochondrial proteins are encoded by the nuclear genome, and are synthesised in the cytosol. TOM20 is a general import receptor that binds to mitochondrial pre-sequences in the early step of protein import into the mitochondria [1].  	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.21	0.71	-4.70	6	100	2012-10-11 20:01:00	2003-07-22 11:48:36	7	11	46	1	51	128	5	147.30	31	55.26	CHANGED	FDRLlhFEHsRKsAEsTYtpNPLDADNLTRWGGALLELSQFQsls-uKpMIpDAISKLEEALlIsPtKH-AlWClGNAaTSauFLosD.sEA+.pF-hAopaFQ.AhsppPsNplY+KSLEhssKAPcLHhthhppt.hp..hGst........ssussSsKohKpKKoS-hKYDlhGWVILAsGVVAWluFAK	..............................................hF-.spctuptthtpsP.D..s-s...LspWGtALlELup...h....pps.....-u....h.p.hlp-AlsKhccALtlsPppa-AlaslGsA........houhu.......h.hp....s-....p....tpA....pphFcc....AsphFppAhs.cP...ssphYppuLph......................................................................................................................................................	0	16	36	43
+6381	PF06553	BNIP3		BNIP3	Moxon SJ	anon	Pfam-B_18014 (release 10.0)	Family	This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation [1].	26.00	26.00	55.60	29.30	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.48	0.71	-4.93	14	210	2009-01-15 18:05:59	2003-07-22 11:56:35	7	2	85	6	101	187	0	181.60	45	95.99	CHANGED	MSssttss................EsuLpsSWVELphsssssspss...............................st.p.lPssSp..sG-hE+lLL-AQ+Epup.SSR....sSSps-SP.ps.oP..pssth.hssp..spps...ppp-cshct..t......KssDWlhDWSSRPENlPPK-FhFcH........PK+.........osshShRpotshKc.ulFSs-hLhlhlPollLSHlLulGlGlaIGKRLsh.spsoh	..................................................ttLpuSWVELphssssss.ss.......................................................................................................s...t.p.lPuosu.hsGD.hEKILLDAQHESup.SS+.......sSS+CD..S..........P.ts.ps..pp..sst...hssc..psp+s..soQSEE-shEtc+-h-.........hpKsuDWlhDWSSR..P..ENlPP.K..EF.hF+H.....................P..KR.........osoLSMRpous..M...KKGGlFSuEFLKlFlPSLlLSHl.LA.lGLGlYIG+RLssso.s..h............................	0	17	28	61
+6382	PF06554	Olfactory_mark		Olfactory marker protein	Moxon SJ	anon	Pfam-B_18049 (release 10.0)	Family	This family consists of several olfactory marker proteins. Expression of the olfactory marker protein (OMP) is highly restricted to mature olfactory receptor neurons in virtually all vertebrate species from fish to man.	25.00	25.00	76.60	76.50	19.10	17.70	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.74	0.71	-4.68	4	40	2009-01-15 18:05:59	2003-07-22 12:01:40	7	1	27	7	9	43	0	138.60	65	94.58	CHANGED	hELsFs.DhQLTchMRLRVQSLQQ+GpK+QDGE+LL+ssEpVYRLDF.ScQcLpFspWNVsLpuPG+lsITGTSQhWTPDLTpLMTRQLLEPsulFWRps...-s-slcC.EADAQEFGERIAELAKlRKVMYFLIsFt-GssPtslcCSlsFpp	........h-hshs.D.pLTc.MRLRVpSLpQRGpKRQDGE+LLpPsEuVYRLDF.ppQ.+.LpFpRWsVsLcpPGKVTITGTSQhWTPDLTNLMTRQLL-PsAlFWRc-...-s-shchpEADA.EFGERluELAKlRKVMYFLhsFt-GscPsslcsSlsFp...	0	1	4	8
+6384	PF06556	ASFV_p27		IAP-like protein p27 C-terminus	Moxon SJ	anon	Pfam-B_18169 (release 10.0)	Family	This family represents the C-terminal region of the African swine fever virus IAP-like protein p27. This family is found in conjunction with Pfam:PF00653. It has been suggested that the family may be a host range gene involved in aspects of infection in the arthropod host, ticks of the genus Ornithodoros [1].	25.00	25.00	26.80	26.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.89	0.71	-4.25	2	20	2009-01-15 18:05:59	2003-07-22 12:41:11	6	2	16	0	0	9	0	129.00	90	57.50	CHANGED	ATLGIIGLKKMIDSYNDYasNEV.VKHKNRVYTHKRLEDMGFSKsFMpFILANAFhPPYRKYIHKIILN-RYFTFKFsAaLLSFHKVNLDNQhTYCMTCGIE.IpKDENFCNACKsLNYKHYKhLNFSVKL	...........ATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTH.KRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL...........	0	0	0	0
+6385	PF06557	DUF1122		Protein of unknown function (DUF1122)	Moxon SJ	anon	Pfam-B_18183 (release 10.0)	Family	This family consists of several hypothetical archaeal and bacterial proteins of unknown function.	25.00	25.00	33.90	65.80	24.60	23.60	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.16	0.71	-5.10	6	37	2009-01-15 18:05:59	2003-07-22 12:43:05	6	1	37	3	20	29	0	155.50	43	86.76	CHANGED	lG.pl...pLcu.clhQs+hpE.psFplhl...ss+..pLspshhFpGRt.YYhPWIEI.shsP.LR........ptslEscLacFlhshLssuG+lFVpYhcD+EThptL.+GhsPAsTcLGFpLLKtGFTWFKsWYaPEGh.EGG.KlQApKPLoc-ccpRpLppLhcElK.phltph.sStlt	....hhhht.......s.sl+ps+hpE.hshpLhl....ssc..plspsphFpGRs.YYsPWlEl.sh.Phhp.........spslEcphacllhpaLsPGu+LFVpYlcDpETtptL.+GhsPs-T.LGhpLLpsGFTWFKDWYFPEGG.EGs.KLQusKPlst..th+pLp.lht-lc..p.h.........t..........	0	7	10	16
+6386	PF06558	SecM		Secretion monitor precursor protein (SecM)	Moxon SJ	anon	Pfam-B_18197 (release 10.0)	Family	This family consists of several bacterial Secretion monitor precursor (SecM) proteins. SecM is known to regulate SecA expression. The eubacterial protein secretion machinery consists of a number of soluble and membrane associated components. One critical element is SecA ATPase, which acts as a molecular motor to promote protein secretion at translocation sites that consist of SecYE, the SecA receptor, and SecG and SecDFyajC proteins, which regulate SecA membrane cycling [1].	25.00	25.00	28.50	28.50	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.94	0.71	-4.53	10	529	2009-01-15 18:05:59	2003-07-22 12:49:01	7	1	522	0	41	182	1	145.30	72	84.14	CHANGED	MVAASLGLPsLssuupsss..Pupuoops+psSspssFssLALLcsssRRP..oFoVDYWHQHAIRTVIRHLSFAh.APQslPsupEs.......sPLQsQHLALLDTLsALLTQEupPPsllR...phspssFhP...usaplulWIuQlQGIRAGPptLS	..............MVAASLGLPALS.NAAEsNA...PAKATopNHpsS.........AKVNFuQLA.....LLEAssRRP.......Na.SVDYWHQHAIRTVIRHLSFAM...AP..QTLP..VAEEo........hPLQ.AQHLAL...LDTLSALLTQEG..TPsptsh....Rl-aAaFsP..QAp.FSoPlW.ISQAQGIRAGPQRL....	0	1	9	24
+6387	PF06559	DCD		2'-deoxycytidine 5'-triphosphate deaminase (DCD)	Moxon SJ	anon	Pfam-B_18211 (release 10.0)	Family	This family consists of several bacterial 2'-deoxycytidine 5'-triphosphate deaminase proteins (EC:3.5.4.13).	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.94	0.70	-6.07	17	532	2012-10-03 01:18:03	2003-07-22 12:52:18	6	3	521	4	109	933	819	232.00	47	87.95	CHANGED	hstsh.....sGILP-csItshhusGtIssshshsssQIQPASLDLRLGspAaRVRASFLPGsuRoVs-RL.--hthHclDLocGAVLETGCVYlVPLhEuLuLPsslsAsANPKSSTGRLDlFTRlITDputtFDplsAGYsGPLYsEISPRTFslLVRsGsRLsQlRFRpGpshLs-s-LttlHtppsLssu..tsh.ssGlulSVDLtuptss.LVGYRAK+HoGVlDlD+hGsacst-FWEPlhspsup...LILDPGtFYILsS+EAVplPPshAAEMsPasshVGEFRVHYAGFFDPGFGpssAGGsGSRuVLEVRuHEsPFlLEHGQsVGRLVYE+MsstPssLYGtsluSNYQuQGLKLSKHFtu	..............................................................................p...........LsDpDIc.Ahl-.pG..t.luh...s.s.t.s...s...-pIpsAolDlRLGs..+...s..a.R.s....+....Au....F......L..s.....G.P.p.c.....p.V.us.t.L..-+..l....h..........c...E......I...s....L..s...-..G....t..s..L..c.s......Gplh.lss.......hLESlsLP.u-lsuhhsu+SShuRLsLhs+VhAc..............................................................................................................................................................................................................................................................................................................................h...............................................	0	27	64	85
+6388	PF06560	GPI		Glucose-6-phosphate isomerase (GPI)	Moxon SJ	anon	Pfam-B_18250 (release 10.0)	Family	This family consists of several bacterial and archaeal glucose-6-phosphate isomerase (GPI) proteins (EC:5.3.1.9).	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.26	0.71	-5.26	6	215	2012-10-10 13:59:34	2003-07-22 12:56:42	6	3	164	25	77	297	86	161.90	26	66.57	CHANGED	VR+hpDhtulhhDEpsapth.E.hsc-ssY-Vp-htps-c-u-......LpaslThl.PGplGcEahhTpGHaHsp.....ss+PElY.slcGpushLLQp.P-s..........-ltVltscttsslhVPPhauHpolNsG-ssLlhsshhsuDsupcY-sIs+tuGhphhllcsGt..h.ppssss.c	.......................................................h.tt..thh.s.............t.sphhYp.l.h.thht.ppctp......L.aslThl.hPGplGp.Eh...hhTpG.HaHsh.........hsps....ElY.slpGcuhhl.L.Qc...-s............csh..s..lpsptGshlhl..PPsauHp....oINs.G.cp.....s.Ls..hushhsps..huhc..Ytslpptthht.hh..h.h.ppGt.............................................	0	22	51	67
+6391	PF06563	DUF1125		Protein of unknown function (DUF1125)	Moxon SJ	anon	Pfam-B_18065 (release 10.0)	Family	This family consists of several short Lactococcus lactis and bacteriophage proteins. The function of this family is unknown.	25.00	25.00	28.70	28.30	24.10	23.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.84	0.72	-4.27	2	19	2009-01-15 18:05:59	2003-07-22 13:02:46	6	1	16	0	3	7	0	54.60	66	81.59	CHANGED	MTV.lKsphsphIlpFchGsDIEsFSsuFLa+KIKhhcIKNt.-L.hhLEDTKND	..MTV.lKsphsphIlpFchGsDIEsFSsuFLa+KIKhhcIKNt.-L.hhLEDTKND	0	1	1	1
+6392	PF06564	YhjQ		YhjQ protein	Moxon SJ	anon	Pfam-B_18260 (release 10.0)	Family	This family consists of several bacterial YhjQ proteins. The function of this family is unknown. However, the family does contain a P-loop sequence motif suggesting a nucleotide binding function.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.51	0.70	-5.01	9	638	2012-10-05 12:31:09	2003-07-22 13:44:36	7	3	570	0	80	5749	2006	228.30	57	95.90	CHANGED	MslLuLQGlRGGlGTTSlsAALuWALQhLGEsVLVIDhSPDNLLRlpFNlDacppcGWARA.LDGpsWp-uuhRYsstLDLLPFGpLsssEhEs.pt.hpsshutaspslptLpttupYcWlLlDLPt...GhSslTRphlphsDpsLsllpsDANCHlRLHQQsLPsusclLlNchphuSQLQpDLaQLWL.QoppcLLPl.llHRDEAhuEsLAuKQPLGEYRsDSLAAEElhTLANWCLlpht......puss	.................................................................................MAlLGLQGV.RGGVGTT..T...lTA.A.L..A....W.u.L..Q.h....L..G.......E....N.V..LV..l..D.....A.......s...P.....D.....N......L.........L.........R....L........S......F........N.......V........D.......F.......s..........H.....p.......p........G........W.......A........R..........u.....h......L.........D.......G......p.......D...........W.......R..........D.........A.....G......L.........R.........Y.......T......S...........Q....................L.....D.....L....L........P...............F.....G........Q..........L....o.......h......p.....E......p.........E.......N..............s........Qp...........W....Q.......p......c.......L.......u.......-........I.........s...o....u....L.........Q.....p..L........K......A.............S.......G...R......Y..p..W..I..Ll..D.L.Pt........s.uS...l.T...+.Q.L..........l..S.L.C...DH.oL..A....l...l.......p............V............D..............A.............N............C.............H............I..........R.........L............H...........Q............Q..........A.......L...........P..........s..........G.........A.........H..........I........L.....I........N.....s...........h.......R.......I....G.........S....Q....l...........Q.D...D......l.....Y....Q....l....W..L....Q...S.......Q.....R....R.........L......L.....P.....h......l.......I.H......RDE.A.M.A.ECLA.u.K.Q.Pl..GEYRSD.uL..AAEElLTLANWCLLp.uG..hKo.......................................................................................................................................................................................................	0	5	16	51
+6393	PF06565	DUF1126		Repeat of unknown function (DUF1126)	Moxon SJ	anon	Pfam-B_18695 (release 10.0)	Family	This family consists of several eukaryote specific repeats of around 35 residues in length. The function of this family is unknown.	21.20	21.20	21.90	21.20	18.70	19.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.06	0.72	-4.47	100	901	2009-01-15 18:05:59	2003-07-22 13:48:32	7	10	125	2	576	907	19	33.10	40	13.93	CHANGED	llpYaLsDDTlplhE.shscNS.Gh.stGpaLcRp+	.......hlpYaLpDDTlplhE.sh..hcNS..Gh.stGph.l+Rp+....	0	273	335	466
+6394	PF06566	Chon_Sulph_att		Chondroitin sulphate attachment domain	Vella Briffa B	anon	Pfam-B_16515 (release 10.0)	Domain	This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis [1]. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation [2].	25.00	25.00	71.60	70.70	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.84	0.70	-4.74	3	37	2009-09-11 06:23:37	2003-07-22 13:53:27	6	4	24	0	17	45	0	225.00	74	43.01	CHANGED	lPsPEAGSAl..........EAEssV+SVPAWEsRANDTREcAGsPAAG-DET....ShpEsGSEpAsVGPGVGPEEuLEASAAVTuTAWLEA-SPG..............LGGVTAEAG.SGDoQuLPATLPTPDEALGoSosSsAlPEATEA........SsP......PSPuPGDKPSLlPELPKESPlEVWLNLGGSTPDPp.............uPEPTaPhQGTLEPpPASDIIDIDYFEGLDGEGRGsDhG+FPGSPGTSE+HPDsGGETPSWSLLDLYDDFTPFDESDFYPTTSFY....DDLEE	............................................-suSAh..........EA-t.h+us.shEs+ANsTp-tsu.PsAG---s....ohpt.G..up....u...........hGPEEs.LpASAAVTuTAWLEs-oPG..............LGGsT.sEsG.SGDsQuLPATL.sPcEsLspSshPPAhPEATEA........SsP......PSPTPG.....DK.SP.....usELP....KESPLEVWLNLGGSTPDPp.............GPEPTaPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSEpHPD..T-GETPSWSLLDLYDDFTPFDESDFYPTTSFY....DDL-E........	0	1	1	3
+6395	PF06567	Neural_ProG_Cyt		Neural chondroitin sulphate proteoglycan cytoplasmic domain	Vella Briffa B	anon	Pfam-B_16515 (release 10.0)	Family	This family represents the C-terminal cytoplasmic domain of vertebrate neural chondroitin sulphate proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis [1]. This domain contains a number of potential sites of phosphorylation by protein kinase C [2].	29.40	29.40	36.20	37.20	21.80	29.30	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.78	0.71	-3.98	2	68	2009-01-15 18:05:59	2003-07-22 13:57:31	6	5	29	0	34	83	0	77.70	59	21.61	CHANGED	LYLLKTENoKLR+T.KaRTPSELHNDNFSLSTIAEGSHPN...........................DDPuAPHKlQDPLKstLK-EEshsI..ShuPc.EGuKG-.sshGVsCLpNNLs	...............LalLKTENsKL.R+psKaRs.sSEhHNDNFSLSTIAEGSHPN.................................pD-ssh...................p.php-shK.......s...K--tshsl..ShsPc.Est+..................................................	0	1	4	10
+6396	PF06568	DUF1127		Domain of unknown function (DUF1127)	Moxon SJ	anon	Pfam-B_18606 (release 10.0)	Domain	This family is found in several hypothetical bacterial proteins. In some cases it represents it represents the C-terminal region whereas in others it represents the whole sequence.	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-7.85	0.72	-4.54	170	1368	2009-01-15 18:05:59	2003-07-22 13:57:49	6	3	640	0	307	914	205	40.10	32	58.60	CHANGED	ts..lhpthtpa....pptR....pop.ppLspLo-+pLpDlGl.sR..u-lpp	..........................h.tlhpshpp.W...........pct+..............pst.p....tLpphoDcpLcDIGl.sR...p-l............	0	40	125	194
+6397	PF06569	DUF1128		Protein of unknown function (DUF1128)	Moxon SJ	anon	Pfam-B_18651 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	20.60	20.60	21.40	21.40	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.27	0.72	-4.25	15	417	2009-01-15 18:05:59	2003-07-22 14:07:06	6	1	417	0	40	132	0	68.40	50	95.73	CHANGED	hSppopEslphMI-pI+cKLplVNhullcs-cFssspa-DLc-IY-hVM+K-oFSPSEMQAIs-ELGsLRK	........ht..spE....MVtuI+EKLphVNtGllcs-cacsss.E-LpDIY-aV.p.REphSPSEhpAIA-cLGpLR+....	1	11	23	32
+6398	PF06570	DUF1129		Protein of unknown function (DUF1129)	Moxon SJ	anon	Pfam-B_18737 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	29.10	29.10	29.20	29.10	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.24	0.70	-5.01	23	957	2012-10-01 22:34:14	2003-07-22 14:10:58	6	1	920	0	81	444	0	203.50	30	88.26	CHANGED	cLTKKNp-alaphp+pL.hpsuho---hpthLp-hlPcll-sQKpGhTARpLaG.sPophspplhps.pptscssp............hhhh.................LDsuLhhlulhslhhGlhshFuptstssh.....GllTLllsuhsuGhshhhhh+alh......hc+scRsshhKthhhlshshllWhslashsuh.LPsslNPsLsshlhllIGulAhulRaal++KYsIpuu	.......................Lop+Nppalh.h..ppph..htssh..o-p-.hctllpcllspllpsQp+GhoApsLaG.sPsphAcuhtpptt.h.pcpsc...........s.hh.hh..............................hDssLh...l...h.....u.l...h...u....llp.u.l....h....s..aF.sp...t.supsh........Gl..l...ol.lh.hu....l.l.uG.hsh.h.h..h.ahalhth.......shspSp+..s..sha..+tl.hlll.h..shh.ha.h.l.lFh.s...suh...L.s..ss.lN..s.h..L..s.s..hshh.Ilu...slhhsl.+.aal+++hsl.s.......................................................................................................	0	15	37	60
+6400	PF06572	DUF1131		Protein of unknown function (DUF1131)	Moxon SJ	anon	Pfam-B_18811 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.60	20.60	23.00	21.10	18.20	17.00	hmmbuild  --amino -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.93	0.71	-4.78	8	552	2009-09-14 12:02:21	2003-07-22 14:28:26	7	2	547	2	43	181	4	169.20	76	88.35	CHANGED	SuhsWSuhuPaNWF...GS.ShEVT-QGVGsITAuTPLsEsAIscALsGDYRLRSGMcTssGplVpaFpAhKscpltlVIsG-.cGsVsRIDVhDscIsTssGVKIGTPFSDLYSKAFGsCppusuD.-ssuVECtAspSpHlSYlFoGcWuGPEsLMPsDDsLKsWcVSKIIW+p	................SSVNWSAANPWNWF...G..S..STcVSEQGVGcLTASTPLpEpAIADALDGDYRLRSG.MKTsNGN.VVRF.FEsM..KG.D..N..VAM.V.ING-..QGT.lSRIDVLDSDIPussGVKIGTP.FSDLYSK.A.F.G.NCQKAcG.D.Ds.puVECKAEGSQHISY.FS.G.EWSGPEGLMPSDDTLKN.W.KVSKIIWRR...................	0	4	12	26
+6401	PF06573	Churchill		Churchill protein	Moxon SJ, Bateman A	anon	Pfam-B_19061 (release 10.0)	Family	This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signaling during neural development (unpublished obs Sheng G and Stern C).	25.00	25.00	36.20	35.90	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.71	0.71	-4.07	7	78	2009-01-15 18:05:59	2003-07-22 14:37:27	6	3	49	1	36	61	1	99.20	68	61.12	CHANGED	MCssCVpcEYPDRGshCLEsGSaLhNFVGCupCspRDFVLIsN+.ssp--DsEEIlTY-HhCKNCcHVIAcHEYTFoVsDDaQEYTMLCLLCG+AEDolSlLPDDPRQ.sPLF	....MCGsCVcKEYPsRGNTCLENGSFLLNFsGCAsCsKRDFhLIoNK.Slc.EED..GEEIVTYD.HlCKNCHHVIARHEYTFSlhDEaQEYsMhChLCGp.u-DohSlhP-DPRp.t.L........................	0	10	12	19
+6402	PF06574	FAD_syn	Flavokinase; 	FAD synthetase	Moxon SJ, Mistry J, Eddy S	anon	Pfam-B_18632 (release 10.0)	Family	This family corresponds to the N terminal domain of the bifunctional enzyme riboflavin kinase / FAD synthetase. These enzymes have both ATP:riboflavin 5'-phospho transferase and ATP:FMN-adenylyltransferase activity [1].  They catalyse the 5'-phosphorylation of riboflavin to FMN and the adenylylation of FMN to FAD [1].  This domain is thought to have the flavin mononucleotide (FMN) adenylyltransferase activity [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.74	0.71	-4.60	62	4652	2012-10-02 18:00:56	2003-07-22 15:00:27	7	15	4320	17	995	3311	2386	148.80	31	49.28	CHANGED	h.tt.pssllslGsFDGVHhGHppllspshphA....pppsl.ssVhTF-P+Ppphhp............pptshc.LoshccKhchlpphG.lDhlhhlsFsppFuplouccFlpphLlppLps+tlllGhDFpFG+pppGshphLpphupths.apVphlssh..phsstclSSTt	....................................pssslsl.GsFDGVHhGHptllpphpc.hA.....................c..p..p..s..l............s.s..VhTFcPpPtp..hht.......................ppsshp....Lsshc-Khchl....tp..h..G......lD......hlhh.l..pFs...ppF...u...p...los.ppFlpphLh.tpL.p.s.+.hlllG.DFpFGp...p.+.p..Gs.hphLpph..ut.....t.....h....s..Fp.lph...ss.ph.....p...p.s.....+.l.SST........................................................................................................	0	342	672	856
+6403	PF06575	DUF1132		Protein of unknown function (DUF1132)	Moxon SJ	anon	Pfam-B_19091 (release 10.0)	Family	This family consists of several hypothetical proteins from Neisseria meningitidis. The function of this family is unknown.	25.00	25.00	83.70	83.50	22.20	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.39	0.72	-3.70	4	69	2009-01-15 18:05:59	2003-07-22 15:24:27	7	1	39	0	3	29	0	94.10	64	89.32	CHANGED	hALYKYQPSSKYFGQSMAlIAppEF.EFs+ssKpasllEsFSaFLN+RlsHNIWKIYFSDESshaI+.....cS.csG+pl+cF.asEhsDs.ssFsslFs	LALYKYQPSSKYFGQSMAlIAQpEF.EFs+.sKp..sVI-CFSaFhN+RlpHsIWhI.FSDpSphhI+......cS.csG+placF.asEhsDs.ssFsslF.........	0	3	3	3
+6404	PF06576	DUF1133		Protein of unknown function (DUF1133)	Moxon SJ	anon	Pfam-B_19184 (release 10.0)	Family	This family consists of a number of hypothetical proteins from Escherichia coli O157:H7 and Salmonella typhi. The function of this family is unknown.	21.70	21.70	21.70	21.70	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.19	0.71	-5.09	4	284	2012-10-04 14:01:12	2003-07-22 15:29:15	6	3	180	0	2	194	0	164.10	76	95.54	CHANGED	MI.PopsGKSGEhlRLpTLESlWIQGKLRMWGRWSYIGGGpuGNMFNpLLuStKlTKTAlNEALRRMKKuGIcKPELEAFhREhlsuKpKShLAaCoDsEuLpIDtVIupVLsc..asGLhullhpRYchR.hSKRpMAEpLpspHP-WshhTCcRRI-sWLulAEphLYsPMsDuFG	.......................MIYPp.TGKS.GEHLRLpTLEuVWIQGKLRMWGRW....SYIG.GG....KoG.NMFNQLLsSKKLT.K...TAINEALRRMKKuGl-KPELEAFLR-MIsGKQK.SW..LuHCT.D.uEALhIDRV....IuEV.LAc..aPGLlslL+Q............RYcGRGMoK.............RKMAELL.N-..............s.H.P.............EW............shp............TCE+RIttWLtVAEahLYhPMh.uF....................................	0	0	0	1
+6405	PF06577	DUF1134		Protein of unknown function (DUF1134)	Moxon SJ	anon	Pfam-B_19217 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	27.80	27.80	28.00	27.80	27.30	27.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.96	0.71	-4.74	26	198	2009-01-15 18:05:59	2003-07-22 15:31:14	7	1	193	0	77	155	20	160.70	59	75.36	CHANGED	ssoYsp-EllsuucsFFGpsotGLApllEcsFpchGpPNGYIlGcEuSGAhlsGLRYGEGsLapKssGc.++lYWQGPSlGaDhGGsuuRshhLVYNLssspsLYpRFsGlsGSAYlVuGhGhshLppssllLlPIRoGVGhRLGlNlGYLKaTpp.TWsPF	.................ssoYot-ElVcuGHcFFGssStGLAsslE+AFppaG.h.PNGYILGEEGSGAFluGLpY.GEGTLYTKNA.G.c....++laWQGPSLGaDaGGpGoRsMhLVYNLsslpsLYpRauGVsGSAYlluGlGhssL+pssIVLVPIRo.GlGARLGlNlGYLKhotpPTWNPF............	0	20	46	58
+6406	PF06578	YscK		YOP proteins translocation protein K (YscK)	Moxon SJ	anon	Pfam-B_19248 (release 10.0)	Family	This family consists of several YscK proteins. The function of this protein is unknown but it belongs to an operon involved in the secretion of Yop proteins across bacterial membranes.	20.60	20.60	20.60	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.59	0.71	-4.93	9	84	2009-09-10 17:11:24	2003-07-22 15:37:43	7	1	78	\N	13	49	2	201.50	43	94.20	CHANGED	sulTsaQhRFCPAuYlccualPsphhhlLs.LPpWRspPslNthLL--huL....-suachPssLGuLALhPputLppLLthLGulLHGpAlRpslLupslpplhsllGp-GtRhLlpQh-lLIGsWPsGWQ+PLPpplc-shhEpsuLpF...WL.....uAsp-hs.sWtpRLsLRLs.ssssssW.lupppRsLApsLChKIAKQVsPQChHLLK	........................................hlTsaQLRFCPAtYlH.spLPuhh......h.p..lLshLPpWRc...s..u..tLNuhLL-cau.L....Dssac..pPpsL..GuLsLhPQutLE..tLLshLGhlLHG.pAlRpslLusslp.p.LhsllGp-shR.ll.Qt-LLIG.sW...PstW.QRsLPsph-pth....h.psGLsF...WL.....AAhpstspsWs+RLsL..RLshsss.stsW.l....sEppRsLApsLChKlsKQVhPpC.HLhK...............................................................................	1	3	5	6
+6407	PF06579	Ly-6_related		Caenorhabditis elegans ly-6-related protein	Moxon SJ	anon	Pfam-B_19267 (release 10.0)	Family	This family consists of several Caenorhabditis elegans specific ly-6-related HOT and ODR proteins. These proteins are involved in the olfactory system. Odr-2 mutants are known to be defective in the ability to chemotax to odorants that are recognised by the two AWC olfactory neurons. Odr-2 encodes a membrane-associated protein related to the Ly-6 superfamily of GPI-linked signaling proteins [1].	21.00	21.00	22.20	21.30	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.94	0.71	-3.93	4	68	2009-01-15 18:05:59	2003-07-22 15:46:10	7	1	9	0	59	59	0	113.00	30	62.49	CHANGED	CMS.hYpshapa..hp+hYpcPtsFospCcDsph-so.h.os.C..pohCVTlhps.cVhuG.hht+tYhRGChsslhh+GaNpo..+Tluhhpp.p.C+shotopLF.sstpc-..t.uclplCSChGshCNhS	........................CMS..Ypsha.....lpphYhhP+sFTcpCpc.pht.tu.hsss.C..pohCVolhEs.sl..............h.ut....h........htptaIRGChsclhhpGhNps..tThth.hpppp.Cpphptp..pLa...th.tp....pplplCoChsshCN.................	2	21	30	59
+6408	PF06580	His_kinase		Histidine kinase	Vella Briffa B	anon	Pfam-B_794 (release 10.0)	Family	This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence [1]. Members of this family often contain Pfam:PF02518 and/or Pfam:PF00672.	21.30	21.30	21.60	22.70	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.71	0.72	-4.06	82	7029	2009-01-15 18:05:59	2003-07-22 15:49:28	8	139	2576	0	1632	5611	368	82.50	32	15.92	CHANGED	clchLpuQlsPHFLaNoLssIpthsphs..sppstphlhpLuchlR..hsl...psppphloLp-ElphlcsYltlpph..Rascclph..ph	...................clcsLpuQINPHFLFNoLssI..p..t..hh..ph..s...s......cc..spphlhpLSphhR..............hsL......pps............p...........ch.....lsLpcElphlcsYltlp.ph..Ras.c.+lphp....................	0	783	1309	1483
+6409	PF06581	p31comet	DUF1135;	Mad1 and Cdc20-bound-Mad2 binding	Moxon SJ	anon	Pfam-B_19462 (release 10.0)	Family	This family is involved in the cell-cycle surveillance mechanism called the spindle checkpoint. This mechanism monitors the proper bipolar attachment of sister chromatids to spindle microtubules and ensures the fidelity of chromosome segregation during mitosis. A key player in mitosis is Mad2, and Mad2 exhibits an unusual two-state behaviour. A Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerisation and converts Mad2 to a conformer amenable to Cdc20 binding. p31comet inactivates the checkpoint by binding to Mad1- or Cdc20-bound Mad2 in such a way as to stop Mad2 activation and to promote the dissociation of the Mad2-Cdc20 complex [1].	24.10	24.10	24.20	25.50	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.64	0.70	-5.52	3	64	2009-12-03 16:30:54	2003-07-22 16:00:29	7	2	48	2	39	60	0	238.90	56	86.91	CHANGED	SsAAAPsL-WYEKPEETHAsEV-.LETVhPPAQEPSNsuEPFCPRD.LVPVVFPGPVSQEsCCQFTCELLKHILYQRpQLPLPYEQLKHFYRK.VPQAEDss+KKsWhATEARNRKCQQALAELESVLSHLcDFFARTLVP+VLILLGGNALSPKEFYELDLSRLAPFGVDQGLNTAACLRRLFRAIFLADPFSELQTPPLMGTIVMVQGHRDCGEDWFQPKLNYRVPSRGHKLTVTLSCGRPSVPAMASEDYIWFQAPVTLKGFHE	................................................Lchh-cst-spsspl-.L-p...sspcs.ps.E.hpPcD.hVPVVFPGPVSQEGCCpFTCELLKHIhYQRQQLPLPYEQLKaFYRK...oP.....QA..E-hh+KK..spsssEso....sRKCQQsLuELESVL...SHL.E.shFAR.TL.VPRVLILLGGsALSPKEFYELDL..S.pLuPhS...h...-pSL.oTuAC........LR+LFRAlFhADsFSEL.QuPPLMGT...lVMsQ.GHRDCGEDWFRPKLNYRVPoRGHKLTVTL..S.....C....G...c.Pu.....l...............s......h.......A..h..EDYIWFQAPVTLKGF+E..............................	0	7	9	20
+6410	PF06582	DUF1136		Repeat of unknown function (DUF1136)	Moxon SJ	anon	Pfam-B_19544 (release 10.0)	Repeat	This family consists of several eukaryote specific repeats of unknown function. This repeat seems to always be found with Pfam:PF00047.	20.30	20.30	20.70	20.30	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-7.48	0.72	-4.17	78	617	2009-01-15 18:05:59	2003-07-22 16:05:55	7	56	46	0	370	869	0	29.10	36	5.14	CHANGED	lhh-oQcPp.....uL..c+IppLEsspp...+...pps	....llh-oQHPp.....uL...c+IppLEsspt...t+....-...........	0	135	170	323
+6411	PF06583	Neogenin_C	Neogenin_C-term; 	Neogenin C-terminus	Vella Briffa B	anon	Pfam-B_16188 (release 10.0)	Family	This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites [1]. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of Pfam:PF00047 and Pfam:PF00041) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues [2].	25.00	25.00	29.10	27.50	20.30	21.60	hmmbuild  --amino -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.40	0.70	-4.86	10	213	2009-01-15 18:05:59	2003-07-22 16:44:25	7	31	76	1	91	194	0	242.30	41	21.17	CHANGED	KDLKPPDLWIHHEchELKslDKSscssPsh.TDTPI.posQDlsPlssohpopsp..s+psSYpGtEoE-uhS.......SLAuRRuhRsK..MMhPhDoQPsps.VlSAhPl.oLDsspa....G.LsSPspuY..HtphShhshshssho...shst..pspusposssTPpsshlPsusupst......................................................................................................................s.ssEEssupSlPTA+lRP......oHPLKSFAVPulPsss..u.hpPtlP.oPlhsQ....................................suso.hstppVKTASlGphG+sRSP.hP...VoVPoAP-lhEsu.+hhEDo-s.......................................sYEsDELScEMAsLEGLMKDLNAITuu	...............................................................................................................................................................................................KDl+PPDLWIHHEchEhKsh-Kus.ssss.h....p-oPl..ps.s.QDl.ssss.pu.pop.p..p+ps...S.....apGt-sE-s..S........oLuuRRuhRsK..h......MhPhDuQs.s....ps...h......t.sh.sh..-pspa.....................Ptpta..h...s.......s....hho.....ht.............sp.ph.ss.pss..hhssspsp....................................................................................................................................stppssupolsouphRP......sHPL+SFusP...hlPssh...s..tstl...oPhhsp........................................tu.s.h.hp.VKTASlG.hhG...+.sRsP.hs....VsVPsAP-l..E..ps...+hh-Dsts.........................................saps--LopEMApLEGLMKpLNAITss.......................	0	20	28	56
+6412	PF06584	DIRP		DIRP	Studholme DJ, Guo, JH	anon	Pfam-B_2017 (release 9.0)	Family	DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9  and  aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.	21.90	21.90	22.20	37.30	20.70	19.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.40	0.72	-4.19	14	225	2009-01-15 18:05:59	2003-07-22 17:01:08	8	4	120	0	127	239	1	104.50	44	15.67	CHANGED	FYSslD+shFp.cs-FtphL.cphs.h+sp+LTRsEWphIRpphGKPRRhSttFlpEERpcLpphRcplRph...pthp.pt...phshhcsL.....Pp-..lsh.PLslGp+VhAhh.t	..............FYSsID+....PhFp..c...s-Ft.hLtEp................h...P.L+.op...+LTRsEWshIRR.M....GK.....P.RR.hSsuFhcEERpcLcppRpplRtL.......Qpp+hss..........su.hcsL..................Pcc..lPh.PLslGs+VoApL+.s.................................	0	44	67	99
+6413	PF06585	JHBP		Haemolymph juvenile hormone binding protein (JHBP)	Moxon SJ	anon	Pfam-B_19686 (release 10.0)	Family	This family consists of several insect-specific haemolymph juvenile hormone binding proteins (JHBP). Juvenile hormone regulates embryogenesis, maintains the status quo of larval development and stimulates reproductive maturation in the adult insect. JH is transported from the sites of its synthesis to target tissues by a haemolymph carrier called juvenile hormone-binding protein (JHBP). JHBP protects the JH molecules from hydrolysis by non-specific esterases present in the insect haemolymph [1]. The crystal structure of the JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organisation of the major cavity and a disulfide bond linking the long helix and the beta-sheet. It would appear that JHBP forms two cavities, only one of which, the one near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance [1]. This family now includes DUF233, Pfam:PF03027.	27.40	27.40	27.70	27.50	26.40	27.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.35	0.70	-5.56	92	924	2009-01-15 18:05:59	2003-07-23 12:02:26	6	11	65	12	627	1020	0	226.30	17	89.17	CHANGED	Mphhhhhh.........hlhhhhhshtttt....................................st.hptCphs.........hspCltpshpp.hh.phss.G..lPch...slssl-Plplsplplpt.....tshshphshpshplhGhss....hplpch....phchp.phphphphthP.plphpG.cYphpGp.llh.......lslpGpGphphshpshphphphphphht..t...ssp..pahpl..pphchphc.l.sphphphpNLFss.sptLspshsphlNpshptlhpphps...slpcshsphhhshhsclhpph.............Phcclh	...............................................................................hhhhh.h....................................................s..ht...Ctht...............hspClhpshpt.hh..htp.G........lPph..slssl-P.hh...l........s.p...hphp......ttsshthphsh.pshplh.Gh.ss............hplpph.............phshp..ph...p.....h..p..h..phphP..p.lph.p...u.p...Y.phpGp..lhh............lslp.upGp.hphsh.ps.hphphp.hphphhp...t.....................ts..pahpl.....pph.phphp..l.tph.p..hph..p.sl.hs.t...sp...l.s.p..hhsphlN....pshptl....h....pphps.....ltpthsp.h.hhs.hhs.phhpphshpph........................................................................	0	184	250	520
+6414	PF06586	TraK		TraK protein	Moxon SJ	anon	Pfam-B_19687 (release 10.0)	Family	This family consists of several TraK proteins from Escherichia coli, Salmonella typhi and Salmonella typhimurium. TraK is known to be essential for pilus assembly but its exact role in this process is unknown [1].	26.00	26.00	26.00	26.10	24.50	25.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.35	0.70	-5.23	26	481	2009-01-15 18:05:59	2003-07-23 12:08:45	6	7	366	0	71	334	15	227.20	29	80.82	CHANGED	M...........hhsllhusslhussh..........tstuspslshss............suphslslSssshNRlslssD..+Is.........slsssputh.....p.pc....psssGslhlp.......shsstshThalpTccGhs..aSltlsPcsssu.colhls..............shstsppcs...tsaEssssY.pptlsplspuhhs....Gphss.Gaphtslspps.......................h......hstsLphp.ttsasGsphpuhhac..lcNtsspslslpEpcFhp.....sust....Alhlspt..pLtPGppsplal	.............................................................................h.hhs.........h.....................huspslshss.......................................GsphslslSsss.NhhslP.s-..clh..........................................slss..s.sth.......t.pp.........psss.G.sllls..........ossppP.hohhlp..sc..p..G..h..s...hSlphlP.+.c.ssu.+slpLs...........................ssht.sssccA......ssW..E.s.u.....s.PY...pshlhsl.pultt.......GclPs.Gat.h.ss.pcs..........................ht.........ssssl..shh..tsthas..Gsc.hphhhat...VcNts.pslplpEpsFap.....sush......AVh.hpp..tpLhsGtchclYV..................................................................	0	19	37	55
+6415	PF06587	DUF1137		Protein of unknown function (DUF1137)	Moxon SJ	anon	Pfam-B_20097 (release 10.0)	Family	This family consists of several hypothetical proteins specific to Chlamydia species. The function of this family is unknown.	20.10	20.10	21.60	179.40	17.00	19.40	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.87	0.71	-4.57	3	37	2009-01-15 18:05:59	2003-07-23 12:11:45	6	1	36	0	4	15	4	159.60	70	98.01	CHANGED	MTKFLFaGLFCSLuLLllACsThVAIIKVDsICDVSCMNK.HFpcAPPFLKIKKLGV+KQIsSPE+QFFaC+IDKSCMELHFSsoSYuCKElLS+LSGHIpTQshEKtMpFRGNGGLLNYQDsSLsVYDCRFpVDPl..asoPDAE-Eh....AsGGMKTLSLSLL	MTKFLFHGIWClVVLlLCAClTALAVVKMGcFTNPTLVHQDssTPAPPFLKIKKLGVRKRIISPEKQhFYCTIDKSCMELHFSNTSLHCRELLSHLTGsLQTETsERAMFFRGTGGLLNYKDYSLSVYNCCFSINs....ssP-uscEh....AEGGMKVLSLSLL.	0	1	1	3
+6416	PF06588	Muskelin_N		Muskelin N-terminus	Moxon SJ	anon	Pfam-B_20299 (release 10.0)	Family	This family represents the N-terminal region of muskelin and is found in conjunction with several Pfam:PF01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1 [1].	19.60	19.60	19.70	19.70	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.37	0.71	-4.63	4	139	2012-10-03 19:46:52	2003-07-23 12:22:06	6	16	96	0	85	129	2	172.00	54	26.47	CHANGED	.pchLsYpIapaSSYSusYlPpNILlDsPpDtsSRWSspT......Ns..QYllLKLc+sAlVpsITFGKacKsHVCNlKKF+VaGGh-pcpMh.LLpuGLKNDsshETFsLphKp.p...p.hsspYlKIVPLhuWGssFNaSIWYVEL+GlDDs.hlpsph+.hshhhEtcul+hCL+aFRppGah-hapsLpcpoplplEHs	..................................phLsatlaphS.SaSss.YlP.c.......NILVDpPsDQoSR.WSopo...........................N...PP.QaLlLKLc+PAIVpsITFGKYEKoHVCNlKKFKVaGGh..s.-..ENM.............sELL.puGLKND..stETFsLKHcl-..............p.....phFPsRaIKI...VPLh.....SWGP.SFNFSIWYVELpGI-DPc.lVp....sslphYspaREpEAI.RL....CLKHFRQ.psYh-AFcuLQ+pTpltLEHP.........................................	2	40	44	63
+6417	PF06589	CRA		Circumsporozoite-related antigen (CRA)	Moxon SJ	anon	Pfam-B_19386 (release 10.0)	Family	This family consists of several circumsporozoite-related antigen (CRA) or exported protein-1 (EXP1) sequences found specifically in Plasmodium species. The function of this family is unknown.	22.20	22.20	22.90	25.00	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.81	0.71	-4.91	3	21	2009-01-15 18:05:59	2003-07-23 12:28:07	6	1	8	0	7	21	1	134.10	69	98.50	CHANGED	MKILSllFL.LFslILsN-ALG-N...sNGchGSGNspKKpsKptSGEPLIDVHDLISDMVRKEEELVclTK+KSsYKLAToVLAoALGVVSAVLLGGAGLVhYNTEKGRHPFpIGuSKsGDuA.scssS.sssEPoP...uP....p-ssPsAophcDssLsSGsEu	....MKILSVFFLALFF.IIFNKESLAEK......TNKGTGSGVSSKK.....KNKKGSGEPLIDV....HD.....LISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRHPFKIGSSDPAtst.....................................................	0	2	3	6
+6418	PF06590	PerB		PerB protein	Moxon SJ	anon	Pfam-B_19494 (release 10.0)	Family	This family consists of several PerB or BfpV proteins found specifically in Escherichia coli. PerB is thought to play a role in regulating the expression of BfpA [1].	25.00	25.00	127.20	127.10	21.90	19.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.89	0.71	-3.85	2	14	2009-09-11 14:43:35	2003-07-23 12:35:24	6	1	4	0	0	12	0	102.70	94	100.00	CHANGED	MKNNLREEKEVVhDGChNVLSLPStWKAITPKKNNsTSEIIVFFIPPKASYHIILKYspTKHCELFFSDHITGEQDlIYSQsAFFSHVINHIIALVDVLNKKSYASNVIKFLITMEGGGDILSESKRAP	MKNNLREEKEVVFDGCMNVLSLPSGWKAITPKKNNsTSEIIVLFIPPKASYHIILKYNKTKHCELFFS................................................................	0	0	0	0
+6419	PF06591	Phage_T4_Ndd		T4-like phage nuclear disruption protein (Ndd)	Moxon SJ	anon	Pfam-B_19553 (release 10.0)	Family	This family consists of several nuclear disruption (Ndd) proteins from T4-like phages. Early in a bacteriophage T4 infection, the phage ndd gene causes the rapid destruction of the structure of the Escherichia coli nucleoid.  The targets of Ndd action may be the chromosomal sequences that determine the structure of the nucleoid [1].	25.00	25.00	26.10	25.30	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.00	0.71	-4.64	2	31	2009-01-15 18:05:59	2003-07-23 13:29:45	6	1	28	0	0	26	0	148.50	58	98.82	CHANGED	.KYhThpDL.ssGupVlusl+sGEa..Go..pK-hhS+.GFYFhV.up.DhR......VuARFaVGpQRSKQGhsAlLSHIRQtRSQLARThusNNl.YsVhalsAppMKPLTTGaGKGQLALAFTRNHpSEYQTLpEMNRhLADNF+FlLQuY	..............................pYMTlpDLpsAGATsIGslK........sGEa.hhGsP.pKD.....I.LocPGFYFlV.uchsu.....ssVuARFYVG.NQRSKQGFsuVLSHIRpRRSQLARTIA..sNs..lsY.sVaYlPASKMKPLTTGFG..KGQLALAFTRNHpS-YQTLEEMNRMLADNFKFlLQAY....	0	0	0	0
+6420	PF06592	DUF1138		Protein of unknown function (DUF1138)	Moxon SJ	anon	Pfam-B_19518 (release 10.0)	Family	This family consists of several hypothetical short plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	25.00	25.00	25.50	25.50	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.38	0.72	-3.97	5	64	2009-01-15 18:05:59	2003-07-23 13:30:54	8	1	30	0	35	50	0	72.60	62	80.72	CHANGED	uKYIIGuLsGSFAlAYVCD+aIADcKlFG..............GTTP+TVosKEWGpATDEKFQAWPRTAGPPVVMNPISRQNFI.VK	...........sKYIluuLlGSFAlAYlCDhhlu-KKlFG..............GTTP+TVosKEWapsTDc.KFQ.AWPRT.AGP..PVVMNPISRQNFI.VK........	0	4	18	27
+6421	PF06593	RBDV_coat		Raspberry bushy dwarf virus coat protein	Moxon SJ	anon	Pfam-B_19630 (release 10.0)	Family	This family consists of several Raspberry bushy dwarf virus coat proteins.	25.00	25.00	25.20	405.60	23.80	17.10	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.60	0.70	-5.17	2	18	2009-01-15 18:05:59	2003-07-23 13:33:28	6	1	3	0	0	17	0	272.80	94	100.00	CHANGED	MuKKAVPP.VKAQYELYNRKLNRAIKVSGsQKKLDASFVGFSEuSNPtTGKPHADMSMSAKVpRVNTWLKNFDREYW-NQFASKPlPRPAKQVLKGSSSKSQQRDEGEVVFTRKDSQKSVRTVSYWVCTPEKSMKPLKYKEDENVVEVTFNDLsAQKAGDKLVSILLEINVVGGAVDDKGRVAVLEKDAAVTVDYLLGSPYEAINLVSGLNKINFRSMTDVVDSIPSLLNERKVCVFQNDDSSSFYIRKWANFLQEVSAVLPVGTGKSSTIVLT	MSKKAVPPIVKAQYELYNRKLNRAIKVSGsQKKLDASFVGFSESSNPETGKPHADMSMSAKVKRVNTWLKNFDREYWDNQFASKPlPRPAKQVLKGSSSK......SQQRDEGEVVFTRKDSQKSVRTVSYWVCTPEKSMKPLKYKEDENVVEVTFNDLsAQKAGDKLVSILLEINVVGGAVDDKGRVAVLEKDAAVTVDYLLGSPYEAINLVSGLNKINFRSMTDVVDSIPSLLNERKVCVFQNDDSSSFYIRKWANFLQEVSAVLPVGTGKSSTIVLT.	0	0	0	0
+6422	PF06594	HCBP_related	HCBP_repeat; 	Haemolysin-type calcium binding protein related domain	Moxon SJ	anon	Pfam-B_20041 (release 10.0)	Domain	This family consists of a number of bacteria specific domains which are found in haemolysin-type calcium binding proteins. This family is found in conjunction with Pfam:PF00353 and is often found in multiple copies.	21.40	21.40	21.60	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.93	0.72	-4.32	116	953	2009-01-15 18:05:59	2003-07-23 13:37:28	6	179	153	0	316	1046	112	43.60	28	9.86	CHANGED	D..Lllplsso......sDplplpshasss........shtl-plpFADGTsWstssl	......................DLllplt..ss........sDplplpsaFpss...............shpl-plpF.uD.G..oshshsp..............	0	121	261	274
+6423	PF06595	BDV_P24		Borna disease virus P24 protein	Moxon SJ	anon	Pfam-B_20092 (release 10.0)	Family	This family consists of several Borna disease virus (BDV) P24 proteins. The function of this family is unknown.	25.00	25.00	36.00	36.00	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.41	0.71	-4.55	3	112	2009-01-15 18:05:59	2003-07-23 13:42:16	6	1	11	0	0	86	0	143.90	73	99.99	CHANGED	MATRPuSLV-SLEDEEDPQTLRRERSGSP.RPRK.VPRNALTQPVDQLL+DLRKNPSMISDPDQR.TGREQLSNDELIKKLVTEL...AENSMIEAEEVRGTLGDISARIEAGFESLSALQVETIQTAQRCDHSDSIRILGENIKILDRSMKTMMETMKLMMEKVDLLYASTAVGTS.APMLPSHPAPPRIYPpLPuuQssD...phDIIP	..................................................LLcpl+KNPSMISD.DQR.TGREQLSNDELIKpLVTEL...AENSMIEAEplRGoLuDIuARlEuGFESLSuLQVETIQssQ+sDaSDSI+lLGENIKILDRSMKTMMETMKLMMEKlDLLYuosAlGss.APMhPSHPuPs+lYPpL...........................	0	0	0	0
+6424	PF06596	PsbX		Photosystem II reaction centre X protein (PsbX)	Moxon SJ	anon	Pfam-B_20149 (release 10.0)	Family	This family consists of several photosystem II reaction centre X protein (PsbX) sequences from both prokaryotes and eukaryotes.	25.00	25.00	31.00	31.00	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.75	0.72	-4.28	22	156	2009-01-15 18:05:59	2003-07-23 13:45:41	6	2	118	15	61	149	93	38.30	48	46.53	CHANGED	MTPSLu.NFl.SLlhGuhlVVlPlssALlhlSQpD+lpRs	....hTPSLp.NFLhSlluGu.lVllsIssAllhVSphD.VcRp.	0	17	43	56
+6425	PF06597	Clostridium_P47		Clostridium P-47 protein	Moxon SJ	anon	Pfam-B_20156 (release 10.0)	Family	This family consists of several P-47 proteins from various Clostridium species as well as two related sequences from Pseudomonas putida. The function of this family is unknown.	19.30	19.30	19.30	19.30	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.56	0.70	-5.97	12	113	2010-01-04 16:41:40	2003-07-23 13:50:17	6	2	34	0	16	91	2	408.90	26	80.93	CHANGED	ThGWDhVauhshphVNct.hphppts.spF..S..hucttplpGsFssWpIhsG......Gsup.lplthPltp...Gsht.hpssshslsGhssslplcLsah.....P.....t.s..otsssphpl.s..hpss.tpps.............t.....tss..........h.pshhptllhphl......pNhcphsalFuolNls..h.pt.phpWhpPs.hpYAYts.sss.psuhLGlLuhsssRsh...u.pLppplDsshlsssupsGhLIScplFlcsllLPsLspsF.ssustssFclhspssp.......hpltsstplsltslpsuuhhYpPhlspFslp.lpsshlphphps+s-ls.Glshhhpshshpshphhhpsssppplsap.spsP...phopcsahsshslIsthlhuslsthlhts................Itutltstls...................s.hs.hlphsss.lpWss...shhslosssLssshphpG	.............................................................ThGWDhVhusshcslNct..hch...ts.......tcF.....sh..pspthph....p..GpFssWplhsG......GsGpplRlKhPIKs.....uhhp......h.....ps....sshshs..s.s..s....h..lplc.Lsah.....................s....p..p.s.....s....ts....s...phph.h.h.psppsp.......pcs.....................t...............p.hhptlhtphh........pNhpphshIFusl.ls...t...chpWhpPsthpYuas......s..ss...........s...........s......ssuhLulLshlss+sh...o.p.ppslDss.hl....s.p....so..p.s.....uhlIScphFlcphlLPs.L.spth.pthssssFplhsp.sp.......htlpNsp....pl...sht..slp...s...s...s...h.hh...P...hl...s..p..hplp..lps..shlhlphp.......st.s..cls...Ghpthhphhp..p...hph.htsssppphsac...hpps....phsppst.s.hphl..th.lhuslsthhhts....................ht..s.h.h.l...............................s..h......l.as....p..php.h.h.s.....................................................................................................................	0	1	7	12
+6426	PF06598	Chlorovi_GP_rpt		Chlorovirus glycoprotein repeat	Moxon SJ	anon	Pfam-B_19883 (release 10.0)	Repeat	This family consists of s number of repeats found in Chlorovirus glycoproteins. The function of this family is unknown.	21.00	21.00	24.40	22.00	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.64	0.72	-4.10	36	321	2009-01-15 18:05:59	2003-07-23 13:53:39	6	11	7	0	0	321	19	34.10	45	25.53	CHANGED	aFlGNGohLoulsss....lsustshDIhGNVsus.uNV	.aFhGNGotLTGlsss....lsushshD...I.h.GNVhus.uNV....	0	0	0	0
+6427	PF06599	DUF1139		Protein of unknown function (DUF1139)	Moxon SJ	anon	Pfam-B_20355 (release 10.0)	Family	This family consists of several hypothetical Fijivirus proteins of unknown function.	25.00	25.00	26.10	25.90	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.05	0.70	-5.25	3	19	2009-01-15 18:05:59	2003-07-23 13:56:02	6	1	7	0	1	19	0	275.40	53	99.24	CHANGED	M-psps-EYuSY.pStslEFDPpcPpINLVNsDFDEsDYsDL-VlLLosDasclpslAl.RIKNAP-YTsEIFEclDslssFs-LFDoEIlEcWsDhDsFhDLRls-sEs-FEhlSShLT+HhQollsspPslLWoolspLAKpSVIQus-D.FsllNYWchMNRRWEhIs-ELRlsFlFRAFcLKusQhtpVS+ILSsSLhFPGLNLIGK+ShIPMhoNaSIPEYLDHWFPTDDYcSDNYLpFIRFsElssscWKKIVVQaYLRpVFS..+VRTKl.......LIAssDVDaWYoLFMRTLIF+SMl+TKsLIKslLNa	...................................MsYshuscYuSh.+SssLEFDPpDPElNLlNQ-FDEsDYpDL-VN.LS-DLSslNLlAT.RIKNuP-YTsEIF-ShDsP.PFApLl-pEIu-EWCDhsNFhDLRlV-sEs-FEFVSSHITcHLLIlLNSNPNlLWTussLLsKlSLlQcssN.F-llNYWcAMsRRW-lIsD-LKhGFVFRAFsLKuNQFElloKLLSDSLhasGIslIGK.SMlPMlTlHSIs-YlDHWF.T-sapSDNFhSFI+htpITVPKWKKlVVQFYLRQlFS..RsRTpV.......LhApsDlDaWYslFM+TLlFKSMh+TKphlKplLN........	0	0	0	1
+6428	PF06600	DUF1140		Protein of unknown function (DUF1140)	Moxon SJ	anon	Pfam-B_20379 (release 10.0)	Family	This family consists of several short, hypothetical phage and bacterial proteins. The function of this family is unknown.	25.00	25.00	25.30	74.20	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.29	0.72	-3.91	3	56	2009-01-15 18:05:59	2003-07-23 13:57:53	6	1	51	0	5	32	0	100.70	57	95.67	CHANGED	MTsEDIVpsYpclILKcIFKEIpp.hKoKERA-ls+pKlAEoGhuVRTSRHWKAsuNlEFYI+EhpctLcQLtELDRpa+WScKLHQDRapFVoKYscVLEEY..RptN	......-llppYpshlLKhIhhcIpp.hKpKE+A-lst.chAEsGs..sVRTStaWKusuNhEFYhpEh.cthsthtElDR.hpWSc+LHQ-phKFVpKY.clhEcY..RpuN.....	0	2	4	4
+6429	PF06601	Orthopox_F6		Orthopoxvirus F6 protein	Moxon SJ	anon	Pfam-B_20433 (release 10.0)	Family	This family consists of several Orthopoxvirus F6L proteins the function of which are unknown.	21.30	21.30	21.30	38.70	21.00	19.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.53	0.72	-4.05	2	33	2009-01-15 18:05:59	2003-07-23 14:00:38	7	2	20	0	0	17	0	71.80	88	96.03	CHANGED	MSKILTFVKNKIIDLIpNDQIKYSRVIhIEESDSLLsVDEVaANHGFDCVEMIDENI.NENlEQYKT-SFhp	MSKILTFVKNKIIDLI.....NND.QIKYSRVIMIEESDSLLPVDEVHANHGFDCVEMIDENI.NENlEQYKT-SFhp......	0	0	0	0
+6430	PF06602	Myotub-related		Myotubularin-like phosphatase domain	Vella Briffa B, Bateman A	anon	Pfam-B_795 (release 10.0)	Domain	This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate [1]. Mutations in gene encoding myotubularin-related proteins have been associated with disease [2].	21.40	21.40	21.40	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.10	0.70	-5.68	24	1877	2012-10-02 20:12:17	2003-07-23 14:09:10	9	82	275	6	1093	1689	23	293.90	29	40.75	CHANGED	pLaAFtapsttst.t.p......ua........................phhchhpEacRh..........................................................Gls..spt........WRloslNcsYplCsoYPttllVPpsloDp...tLtpsupFRuppRlPVloahH.cstAsIsRsSQP....LlGh..spRstc............DE+ll.psl..................................................htspspscchhIhD.........................sRsphsAhAN+ApGuGhEspstY..................pschhFhsI...tNIHshRpShp+l...................hcss.....hptss.spalosL-sotWLpHlpslLpuushlsptl...c.cpsSVLVHCSDGWDRTsQlsSLApLhLDPYYRTlcGFpsLlEKEWluFGH+FucRsGHh................................................................tspsspphSPlFlQFLDCVaQlhcQFPsuFEFsEtFLlplhcHhaSCpFGTFLsN.sE+ERtcp	...........................................................................................................................................................................................................................................................th...............................p..t-hp.R...................................................................shs.....................W..+l....o.th...Np...p.a....p..............l...........s.oYPth...........lhVPt..th...s....-p........l...t..s.uthh...............pttRhP....................s..ls.........a...................h......p....t..s.t.....s.sl..h.R.....s..u...p.............su......t.ps.p.............................................--ph.l....thh.................................................................................................................................................................................................p...hl...hD........................................................................................t+s....h.t.t..............t....h.h.u..c...............h.......................................................................................hp...h...ht.h...........sl...+.....hp....p....ohp.pl...................................................hphs......................s.......tp.ah.....p..tlc.........po..t....W.L..p.h.....lp........hLptuh.l..sp.hl...............p...tt...sVl.lp........p....p.-G.hD.h..T...s.p.l...su.LsplhL......D.P.a...a........RT....l..cGF.............s......L...l-+-WlshGH.FtpR..hs.ph...........................................................................................................................................................................................................................t.t..p.pp.uP.l.......F........h.FlD.sVaQ...............l..h.pQ.......aP.ttFE....Fsp.ha........L..hh.lh.ph...........hus.auoFLhs.sttpR...h...............................................................................................................	0	353	476	753
+6431	PF06603	UpxZ	DUF1141;	UpxZ family of transcription anti-terminator antagonists	Moxon SJ	anon	Pfam-B_19606 (release 10.0)	Family	The UpxZ family of proteins acts to inhibit transcription of heterologous capsular polysaccharide loci in Bacteroides species by interfering with the action of the UpxY family of transcription anti-terminators. As antagonists of polysaccharide locus-specific UpxY transcription anti-terminators, the UpxZ proteins exert a hierarchical level of regulation, insuring that only one of the multiple phase-variable capsular polysaccharide loci per cell characteristic of this genus is transcribed at a time.	21.20	21.20	22.40	21.80	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.29	0.72	-4.02	13	133	2009-01-15 18:05:59	2003-07-23 14:15:26	6	1	25	0	19	121	0	104.90	51	69.86	CHANGED	plpsLQpsAHELLYLGhDGuPIYoDcFspLNpEVhppsssLasp..+GsTsEEEAsLCLALLMGYNATlYs.pGDKEp+hQslL-RsasVL-pLPASLLKspLLThCYG	..............hpsLpphAH-LlYLGhDGuPIYoDchspLNpEVacpsssLYsp..+GsTsEEEAslCLALLMGYNAohYs.pG-KEp+lQplLcRsaslL-pLPASLLKspLLThCYG.......	0	5	11	19
+6433	PF06605	Prophage_tail	DUF1142;	Prophage endopeptidase tail	Vella Briffa B	anon	Pfam-B_16284 (release 10.0)	Family	This family is of prophage tail proteins that are probably acting as endopeptidases.	27.70	27.70	28.00	27.70	27.40	27.60	hmmbuild  -o /dev/null --hand HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.75	0.70	-5.51	23	808	2009-09-16 13:04:28	2003-07-23 14:19:08	6	22	565	1	80	610	5	344.80	18	55.62	CHANGED	hs.plNsptsloFolhpscpNtpsashlsp..cphlha.....sspcYhIpphstps.Gpsht.hplpApH.lh.-lpsphlhpph..........sGs.........................holcshhc..hshpsoG..aoYpltss.hsshphp...shGs.pstL-lhppllcpa.GsEapsss+plp.lh..cplG.ppsshhlRataNhsslshphDssslhTtI+GYGc......................................................................................................................................................................................................................................................................................................................tppsstsphh.....h.hcYpSP.A.ch..aGh......+husslpD-RhTstssLcpthKpplp..csPchSlslsh.phpp...hhth.pcstlGDhlhlls-s...lGlshclRlVuhpp.hshssph...clshush......ppshsclhsplspsh+thp	......................................................................................................................................h...t.Nttt.lshsh....st..p.........phl.p....t.hl.h.......ptp.p......Y..hI.h.hs.p...tu.pt....lplpApc..hh.c.hp.p.p.hh.....sph.................sss........................................................hohpphhp......h..s...p...tos.....h.p.a.p.hh..ss...hp.p.h.p.hp.........phsp..pstl..-hh......p......phlppa....s..t.-....h.........h......h.........s.........s.....p..........p....l.......t....hh..p.p.....h....u.pc......ss..h..h..lphthNh..pslp.hphsspplhTtI..h..sa...G.p...........................................................................................................................................................................................................................................................................................................................................................................h..s.s.t..p..st......s.tht............h.h...p.......a.p.s....s.s...ch....aGh.............................h.u............s..h...p.-.pc...h...p..s...t...c..s.......Lh....ch..s.cp...plp........sp....Pp..hoh...sls..hh.l.t...........hsh.pphphGDsVh.lhpcp....hG..hs.s..plRllchpp.....pshhst....h....pplslush.................pcshh.p.h.p.thtp......p.................................................................................................................................................................................................................	0	36	62	77
+6435	PF06607	Prokineticin		Prokineticin	Moxon SJ	anon	Pfam-B_19802 (release 10.0)	Family	This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock [1].	21.30	21.30	21.50	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.47	0.72	-3.89	7	187	2009-01-15 18:05:59	2003-07-23 14:30:20	6	5	59	2	84	172	0	94.80	39	70.82	CHANGED	M+.phhphslLL....Lll........ssucuAVITGAC-+DhQCGsGhCCAVSlWlRulRhCTPhGppG--CHPhSHK.....................VPa.GKRhHHTCPCLPsLsCs+hsss+Y+Ch	.................................................................hhh....hhh...........s.....hh.l....oGuC-.+DspC....Gs.G....h.CCA...h..S.hWh+.u..l..phCsPhGppG-pCH..Pho+K........................l..P..a.....s.......c..R.ha..ppCPChPsLhCpph.....................	0	26	29	41
+6436	PF06608	DUF1143		Protein of unknown function (DUF1143)	Moxon SJ	anon	Pfam-B_19953 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins (from mouse and human). The function of this family is unknown.	20.40	20.40	20.40	20.40	20.20	18.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.21	2	50	2009-01-15 18:05:59	2003-07-23 14:32:26	6	2	35	0	31	49	0	132.60	55	82.63	CHANGED	hAspC.hspphhLQRQNLsCaLpNPHhGSlI.ADGHGEVWTDWNsMSKFhQYGWRCTTNENuYSNRTLhGNWNQERYDL+NIVpPKPLPSQFGHhFETTYDssYspKhP.STHRFKREPHhFPGHQPELDPP+YKCTtKSTYMssYScs	.................................h.hahtNPph.GSllpAsGHGEVWTDaNshSKFhQYGWRCTTNEssY.SN+TLhGNWNQERYDl+slV.QPKPLP..SQ.FuHYFETTYD..oSY.N....s.K...hP.S..........T..H...RF......K....REPHhFPGHQPELDP..PpaKs..T..t.+SshM.sYs........................................................	0	10	13	17
+6437	PF06609	TRI12		Fungal trichothecene efflux pump (TRI12)	Moxon SJ	anon	Pfam-B_19969 (release 10.0)	Family	This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes [1].	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	599	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.97	0.70	-6.33	2	214	2012-10-03 03:33:39	2003-07-23 14:37:16	8	8	86	0	151	7876	315	457.40	22	86.41	CHANGED	MTssV.EcGlDLESQPDDRhRApALAToAsELP-GYYpSPRllASFAuFShNVsATYFVLQASASALPNILQDlGQSENpuLFSTLWThGQAVSILhMGRLTDRFGRRPFVIhTHIlGLVGAIVGCTAsKFNTLLAAMThLGVAAGPAGuSPLFlGELMSNKTKFLGLLhVShPslshs.huPYhGQRLuIQGsWRWIFYIYIIhSsIAVhLIllWYaPPSFtQLHGKKspKR-ELAKlDWIGIhLV.sGsSLFLLGVSWGGpPNsPWNSuKlIGLhoSGhGoLVlFALYEVaGKP.pPhlPPuLFKDTRGFVCILlISSIMGuMpLsLsIhYPQQVlNIFGSSLKNWpETAWMoATASFGThAGVhlLGslFHLlRHIRWQILVGAhWLTAFLGAMSSlNRDNKNuAIALShhoGFVVuWAQDITMLhVQFITTDEsLGVAFuVVAAuRPFhGSIFTAAFISlYoNpYP+EluoHLoSAhRGTshPQuSFsSLLEAApoGRh-AVpALPGMTspIuuVVSpAMADSYTASYANVYYFAMALGVIPIIASLCMRDhDpYLTDHVPHQlYDRKpAcKDVL-GsS-o.sSPhIhShs-hc.	......................................................................................................................................h...............................................................................................................................................................................................................................................................................................................h.....h.....s......h..........h..................h.....s...........u...h.........h..............h....h....G.p.......l..o..D..h..h.G.R.+............h..h....l...h..s....t....h...l..h.l..l..G...........I...l...s..s..s......A........p...s.........h..........s.....t....h...l..u...u.......s...h............h.......G...h........u....s......G.......h......t..........h....h..........h........h......h.......u.....-.....h...........h...........s................+......h......+...........h.........h.......s......h.....h........h......h.........h.....s...................l.....h..................................h.....u.....s......h.......h.........u.........p..........h.........h.....s.........h.....t.........s.........s..........W.....R..a........h......h.....h..h...h....h..........l.....h...s.......s......l...u.....h....l....h......h......h..............h..........a..........Y..............a............P..............P..........s.....................h...................p..........h............p..........s........p.......t..........h.......p.........p.............t................p.....................l.......t............c........l........D.....a........l........G...h..h...L......h..h..s...G.l.s....L..FL.l....G....l....................s......a..G..G..............t......................s......W..s.S...u.+.l..l..u...........l.l.....h....G..h.......s..h..L..l.s..F....s..l...a....E.......h....a.......s...t.................p....p.............P.....h......h.....P.......p...L...h.p.......p............R....s......h...s....h....h....l....l.....l......s....h...l.......G......h..........h...h..s....h.......h....h...a..P....p....t.h.....h...s...l..a..s.....p...s...............................h....s..h...h.......s...h.....s...........h....s.h......u....h.h..h.u..s....h....l..............h....h......l....h.....p.......h....h....t...c...h......+......h...........h...l.......h..u...s......h...h..h...s...s...h...h..G...s....h....u...s..h..p.....p..s........t...h...h....h....u.h........h...h.....s....s.........h..s...h...u.h....h...............s........h....h......s....p...h......h....s....s......t.....p.................l..u...h..s.......u..l..h....h.......s..........R.........h....h....G....u....l....h.h.s....h....a...........s..l.h........s.......t.h...............h...s....t.........l....s.............s...h...h................s...h.s...........t...........h............h...h..t......h.......h.............s....................h........l........s.u.h.s.......t.......h...t...hh.......u....h.t........uas.u...h.......s..ahh..s.hs.h.uhl..shh.sshhh.....s...t...............................................hh.............................................................................................................................................................................................................................................................	0	41	82	125
+6438	PF06610	DUF1144		Protein of unknown function (DUF1144)	Moxon SJ	anon	Pfam-B_20026 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	32.00	32.00	21.40	19.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.76	0.71	-4.43	14	617	2009-09-10 16:34:19	2003-07-23 14:39:04	8	1	613	0	40	182	3	138.80	78	95.31	CHANGED	Mh..pss.phRsAsADTFAMVVaCFlsGMhIElhlSGMoFEQSLuSRLLSIPVNIhIAWPYGhaRDahlRput+luss+.ah+sluDllAYVoFQSPVYAsILhsVGAshcQIlTAVoSNhVVShhMGlsYGYFLDhCRRhFRVs	....MF...SPQSRLR.HAVADTFAMVVYCSVVNMhIElFLSGMSFEQShhSRLVAIPVNILIAWPYGhYRDLhMRsARKlSPo.G.WhKNLADlLAYVTFQSPVYlA.ILLsVGADWHQIhAAVSSNIVVSMLMGAVYGYFLDYCRRLFKVS............	0	4	10	25
+6439	PF06611	DUF1145		Protein of unknown function (DUF1145)	Moxon SJ	anon	Pfam-B_20029 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.60	20.60	21.60	20.90	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.76	0.72	-4.34	33	759	2009-01-15 18:05:59	2003-07-23 14:41:03	7	1	737	0	88	256	38	60.30	54	67.24	CHANGED	hllsLGKhlhLhhWhhllhNLlhPFssslslhlslhhshhllMHslQlllhpush.tc..s	......MLINlGRLLMLsVWuF.LILNL..VpPFP+PLN..IFVNVALlFhlLMHGhQLALLKSTlPKDu.........	0	8	25	56
+6440	PF06612	DUF1146		Protein of unknown function (DUF1146)	Moxon SJ	anon	Pfam-B_20141 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	28.30	27.60	24.20	23.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.15	0.72	-4.05	27	920	2009-01-15 18:05:59	2003-07-23 14:47:08	6	1	916	0	83	368	1	47.40	37	64.26	CHANGED	LhFIsluaWALpul.+h-phh+ps..+shQsplLhlhloIulGhhVSsFFL	......llhIhluaauLpul.+h-phhKps..pstpl+lLhlFluIslGahVSsFhl..........	0	18	43	62
+6441	PF06613	KorB_C		KorB C-terminal beta-barrel domain	Bateman A	anon	Pfam-B_20369 (release 10.0)	Domain	This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon [1]. This beta-barrel domain is found at the C-terminus of KorB.	25.00	25.00	26.50	25.50	24.40	23.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.74	0.72	-4.52	4	67	2012-10-01 19:11:18	2003-07-23 15:26:40	6	3	57	6	10	53	6	59.80	61	17.01	CHANGED	uDPD+hKKsll.VEHDsRsAtllLNRRPsstGhhal+YEDsGt-hEs-hGslKlshLhEu	....sDPDKLKKAIlQVcHD...sR.PARLlLNRRPsu-GaAWLKYEDDGpEFEADLusVp.LVALlEG.	0	1	5	8
+6442	PF06614	Neuromodulin		Neuromodulin	Moxon SJ	anon	Pfam-B_20438 (release 10.0)	Family	This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with Pfam:PF00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals [1].	25.00	25.00	51.40	51.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.32	0.71	-4.33	3	57	2009-01-15 18:05:59	2003-07-23 16:13:59	6	3	36	0	20	47	0	160.20	64	70.86	CHANGED	sKKDEuPuu-uVENKcGEAoTATEAosA-ouKsDEPoKDG.........SoPoEEKKGpGuuDsuoEQPAPQAsss...SEEKsASA.ETESATKASTDNSPS.KAD-APsKEEsKKADVP.hlTshAsTTPAAEDATAKAssQPppETuESSQsEEKpDAVEETKPoESAQQEEuKEEEuKADQENA	...........................pKKDEuP.s.A-GVEKK.GEGsss.TEAAPAsGsKs-E.s.uKAG.........EoPSEEK.KGEG...DsuoEQsAPQAsAs...SEEKA..GSA...ETESATKASTDNSPSSKAEDAPAKEEPKQADVP.AVTsA..AATTPAAEDAAAKATAQPPTETuESSQuEEch.-AV-ETKPpESApQ-EsKtEEscADQEpA...................	0	1	1	5
+6443	PF06615	DUF1147		Protein of unknown function (DUF1147)	Moxon SJ	anon	Pfam-B_20563 (release 10.0)	Family	This family consists of several short Circovirus proteins of unknown function.	25.00	25.00	32.70	53.20	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.99	0.72	-4.14	3	8	2009-01-15 18:05:59	2003-07-23 16:21:12	6	1	6	0	0	6	0	54.50	98	100.00	CHANGED	MYTSLWGHLGVVKANGLLILQTRKPHTGNHLETSGGMVTMVKKWLLLMTFMAGCRGMIY	MYTSLWGHLGVVKANGLLILQTRKPHTGNHLETSGGMVTMVKKWLLLMTFMAGCRGMIY	0	0	0	0
+6444	PF06616	BsuBI_PstI_RE		BsuBI/PstI restriction endonuclease C-terminus	Vella Briffa B	anon	Pfam-B_16289 (release 10.0)	Family	This family represents the C-terminus of bacterial enzymes similar to type II restriction endonucleases BsuBI and PstI (EC:3.1.21.4). The enzymes of the BsuBI restriction/modification (R/M) system recognise the target sequence 5'CTGCAG and are functionally identical with those of the PstI R/M system [1].	25.00	25.00	30.50	30.40	23.20	22.80	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.64	0.70	-5.62	22	135	2012-10-11 20:44:44	2003-07-23 16:25:22	6	3	130	2	34	117	7	280.90	40	82.08	CHANGED	EutpIhhp.uhstp.ps....EpSALs..............s-upp.hhshsshhshtcpthu+.YAsNTREolRcpTl+phl.ushAl........s-psshPssSs+ssYplpsphhsL.........LcuhsoshhpcpLsthhhpRhsLlpphA.spttspIsVphPsGcphpLuPG.pS.LhKsllEpFAPRFhss.stllalu-o......GsKhshhDcpLhpp.LGlslcuctchPDllLh..tcsah......lhlEsVsScGPlstcR+ppLtpLhpsu...pssllaVTAF.sRut..hp+hls-lAWcT.VWhAspPsHLI+h.sGtphltPap	.....................Atpllhpluhsttpps....-puAlshLAlhslp.tptW....ssA......ps.....hlshp.s.lhsahccta.........s.+..........YAsNoREThR+pohHQFhtAslsl.ss-cPs+ss.NSPpssYplpsthlsl.........L+sas......ost....ac..ppLs..saltp+tsLhppaApp+ptsplPVplssGpphpLSPGtpspLh+ulIE-FAPRFsss.uhllYlGDT......upKhshh-tthLtt.LGlslss.HsK...hPDVVLa.ps+sWL......lLlEuVTScGPVss+R+tELtcLhtsu...suGll.aVTAF.sRst...h...p+alu-lAWETEVWlA-tPsHhIHa.NGs+FLGP..........	0	9	24	27
+6445	PF06617	M-inducer_phosp		M-phase inducer phosphatase	Vella Briffa B	anon	Pfam-B_16267 (release 10.0)	Family	This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the Pfam:PF00581 domain. These proteins are involved in the control of mitosis [1].	21.70	21.70	22.70	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.95	0.70	-5.32	8	226	2009-01-15 18:05:59	2003-07-23 16:31:08	8	5	44	1	76	243	0	186.80	32	45.42	CHANGED	LDSPushDsptspE.................hslpphpShsQ+LLGsSPAh+p.osSsuLDp..hp.tD..th.sssENKENEua.FKhP.h+.h....hpuhh.htpt+-hhsQRpsSAP.hMh.Ss.p+h-l...E-ushhhLuoPpo..ssspsss....cED......DGFlDhL-uEpLc--.tsPsu........MtsLhoAPLVhphpc.ptt...hhsRs.tLaRSPShPsSlsRPhLKRlERspDc-sPspsKRR+Ssos..ptc.tcsppP+p...pl...hp.t.SLCchsIEsl	.........................hDpsu.hDsp...p.....................htt.psh..cLhtpSPs.h..opspu.ct........s.....th..s..spsKEN...-s..hK...........................pp.hhpp..ut..........o.s......p..p.....tt.p.h.hh..p.....ssstt.p........................tED......pGF..h-hhps-.l....cs.-....st.........h..LhssPhh.............t.....................s....+s....tLacSPSh.sp....sh...Rs...hLKR..-+.p-ps..P.psK++ps...s.............p....ps.p.p....h............S.sp.pIpph.............................................................	0	4	7	25
+6446	PF06618	DUF1148		Protein of unknown function (DUF1148)	Moxon SJ	anon	Pfam-B_20595 (release 10.0)	Family	This family consists of several Maize streak virus proteins of unknown function.	25.00	25.00	248.80	248.60	21.10	17.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.68	0.71	-4.13	2	13	2009-01-15 18:05:59	2003-07-23 16:45:23	6	1	13	0	0	6	0	114.00	99	100.00	CHANGED	MRSHTPPEGTVIMVVPtCWSVWIWRDGLSALLPALFSPAEEGFFLETRLFQFESSPRFLLDVDMADCLSRAWNKWPGIALTWWCWYIRDRVAPIHSLSTKYpLLRGSALASLQN	MRSHTPPEGTVIMVVPACWSVWIWRDGLSALLPALFSPAEEGFFLETRLFQFESSPRFLLDVDMADCLSRAWNKWPGIALTWWCWYIRDRVAPIHSLSTKYQLLRGSALASLQN.	0	0	0	0
+6447	PF06619	DUF1149		Protein of unknown function (DUF1149)	Moxon SJ	anon	Pfam-B_20513 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	32.30	32.00	21.00	17.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.73	0.71	-4.21	12	561	2009-01-15 18:05:59	2003-07-23 16:47:41	6	1	557	5	40	153	0	123.10	52	97.03	CHANGED	MplhR-pEFVspYHaDsRNhtWEcENGsPETslcVsFQLlcp-cttp.......sTsllslLpFhIVhDc..FVISGhISQhs+lhsRllscPsEhsQ-ElcpLutPLl-hlcRLTYEVTEIALDcPGlsLEF	............................Mpl+R-.pEFVspYHaDsRNhtWEpENGsPETcl-VsFQLlp..c..-pENp.......sTullllLsFhIVFDc...FVISGsISQlNHIpsRlls-sSElsQEEVEpLuRPhlshlpRLTYEVTEIALDhPGlNLEF........	0	5	14	24
+6448	PF06620	DUF1150		Protein of unknown function (DUF1150)	Moxon SJ	anon	Pfam-B_20612 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	26.10	36.90	24.30	17.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.35	0.72	-4.16	48	249	2009-01-15 18:05:59	2003-07-23 17:04:49	6	1	246	0	83	175	52	74.80	38	89.73	CHANGED	sphs.t...thussplsYVRslpss-Lspch........splsssppLaAlHuA-GpplALscDRchAFshAppp-hpPVoVH	........h..ho.pphApLGtGclAYVRplcs--lspphPt.....hs.lss.u.hpLaALauAsGpPIsLsDsRpsAhtsAtpc-LpsVolH...	0	21	51	61
+6449	PF06621	SIM_C		Single-minded protein C-terminus	Moxon SJ	anon	Pfam-B_21144 (release 10.0)	Family	This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologues in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerisation partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism [1]. SIM2 is thought to contribute to some specific Down syndrome phenotypes [2]. This family is found in conjunction with a Pfam:PF00989 domain and associated Pfam:PF00785 motif.	21.50	21.50	21.50	21.50	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.76	0.70	-4.83	5	112	2009-09-10 21:39:22	2003-07-24 10:21:55	7	9	43	0	54	89	0	243.70	41	40.29	CHANGED	SPosTu.......sEsRKuuKSRso+sKoKsRTSPYP..QYSuFpsDRSESDQDSsWGGSPLTDoASPQLh-ss-csuo....SCsYRpYSDPtSLCYG.FPL..DcHsLScc+sHhHocsC-...uusCEuuRYFLGTPQuGREsWWcsARSlLPLsKSSPENtcua.ElousHtA.lHslcuRGHWDEDSAVSSsPDu..uGSsS-SGDRa+s-pa+SSPpEPSKhETLIRATQQMIK......EEEsRLQh+KhPs-hsLAspsuLuKuap.......spasQushsusVCRusu.s.......................s..spSPssLSRLSS..PpP..............................Dclo+Ss	.................oshsT........p-sRKhsKs+.op.K..oK.R....Ts.PYP..QYSuFph-+..Es.s.p.upWtuS..PhsssAuPQ..p.t...scsus......hhh.paS...ShpYG.FsL..Dpphhsp.c+..hh.sp....hsp...Gu.CEsuRaFLuT..su.tEs.Wt.upshlP..op.usscsh.t...sshs+hs..s.phcu...uth.t...cc..s.s..s..Ps.....ssut.cptstht.t.http..........p..s.t......shhts....phht...........sph...h..................................................................................................................................................................................................................................................................	0	2	6	20
+6450	PF06622	SepQ		SepQ protein	Moxon SJ	anon	Pfam-B_21060 (release 10.0)	Family	This family consists of several enterobacterial SepQ proteins from Escherichia coli and Citrobacter rodentium. The function of this family is unclear.	22.70	22.70	22.90	23.70	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.06	0.70	-5.53	2	115	2009-01-15 18:05:59	2003-07-24 10:27:28	6	2	105	0	1	46	0	275.20	84	98.26	CHANGED	Mp.LNSQ.NMKINDFYLPLLsVIGhGRLYITsEGHACHAYFREVSGNGhRFTLshSGYEGpFWlSEEQhhQWCpELFPYS-SRLIPEDhIKLMlLWshpssLPEsDsSVDDVQFThLNKDlYPVIENNNGcNRLNVIILchTVQSLQYLIN-NWQhVPHSNTlFFDGYIAPGWTDYPlTcLolGDSLRLYHVDDSpERcCWLVINNPLATVKLsDNNL.lsDVQAAD.LChISNEsVMsRIYCsIGTIpVDIHhLRNhKKDDhIsSsGYHLFGGsRLIRNNThIAYGoIlKINEDFY.slSlVCD	.................Mp.LsSQLNMKINDFYLPLLPVIGTGRLYITScGHACHAYFREVSGHGIRFTLTYSGYEGRFWISEEQFIQWCQELFPYSESRLIPEDhIKLMILWV...MQTALPE.GDVSVDD...VQFTMLNKDlYPVIENNNGENRLNVIILETTVQSLQYLINDNW......QFVPHSNsLFFDGYIsPGWTD...YPVTEL...pVGDSLRLYHVDDSpERcCWlV.INsPLATVpLsDNN.L..lsDV..AADLLsslSNEsVMsRIYCsIGTlHlDIHMLRNsKKDDIIsSsGYHLFGGCpLIRNNTTIAYGSIVKINEDFYFTVSlVCD.....................................................	1	0	0	1
+6451	PF06623	MHC_I_C		MHC_I C-terminus	Moxon SJ	anon	Pfam-B_21327 (release 10.0)	Family	This family represents the C-terminal region of the MHC class I antigen. The family is found in conjunction with Pfam:PF00129 and Pfam:PF00047.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.72	0.72	-6.86	0.72	-4.47	14	3480	2009-01-15 18:05:59	2003-07-24 10:35:40	6	6	87	0	199	3309	0	27.80	76	7.99	CHANGED	NoGGKGGsYs.AsupDSuQuSDVSLsssK	.........S.SGtKG....GSYSQ........A.ASSDSAQGSDVSLTA.............	0	71	71	72
+6452	PF06624	RAMP4		Ribosome associated membrane protein RAMP4	Moxon SJ	anon	Pfam-B_20959 (release 10.0)	Family	This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER [1].	21.00	21.00	21.00	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.85	0.72	-4.43	16	291	2009-01-15 18:05:59	2003-07-24 10:42:24	7	7	191	0	175	245	1	60.90	43	70.61	CHANGED	MuusQRM+htNcpaspNlspRGNVPKSh+sp.-cKaPVGPhLLuLFlFVVCGSAlFQIIppIph	..............................sppRh.+.h.uNcK.a.s.K..N.l.T...p.R...GsVscop...+p.....p...p...p...chPV.GPhLLu...lFlFVVsGS...ulFQIIpshp............	0	57	96	143
+6453	PF06625	DUF1151		Protein of unknown function (DUF1151)	Moxon SJ	anon	Pfam-B_21020 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	25.00	25.00	31.80	31.00	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.79	0.71	-4.38	9	174	2009-01-15 18:05:59	2003-07-24 10:44:28	6	3	74	0	98	151	0	114.10	50	72.76	CHANGED	hucPshl-ssssELIhP+KLlNPstsSts+Q-LHRELLhNpKR.GLslppKPELQ+VhEKRKccpllcppc..EEpptp+.....o-LEpELh+RpQ+L...EphEhcptp.pEEpcp.....PEFl+V+upLR+	.................AcP-Yh-tsss.ELI+P.+KLlNPVKsSRsHQ-LHRELLMNpKR...GLuhpsKPELQ+VhE+R+RsQl..lKp+c...EEtpt++.........osLEtE.Lh+RQQ+L...-QLE.pptt.p..EEpcs........PEFl+V+tNLRR...................	0	15	29	60
+6454	PF06626	DUF1152		Protein of unknown function (DUF1152)	Moxon SJ	anon	Pfam-B_21029 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	20.60	20.60	20.70	21.80	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.90	0.70	-5.30	14	77	2009-01-15 18:05:59	2003-07-24 10:46:02	7	3	71	0	40	74	6	273.70	29	79.54	CHANGED	LllulGGGGDVVuAhslsthltp...G.csslGslsWERhVhDPhPGPlshsplpp.sptlsctlhlssscoashRGGRhhhsQsspsucsLspp.V..ahlD.hcGsptlscuLpchhth.thDtllGVDsGGDlLApGsE-sLtSPLADulsLAsLs+lc....puhLtVhG.GuDGELsh-YllpRlu-lA+pGGhluhhGlscpssclLccllchssTEAStlslt.Ah+GcaG.hpIRsGsRpVhlsshuslhFhhDPpslhphsphA+ll.csotol-EAsctLp.phGlhTElchEcsL..Apt	.......................................hhhuhGGGGDlhsuhhhhthh.t...t....pshluslsW-Rhh..DPhPG...Ph.hpphpt..h..lsttlhhls.pshs.t...ssh.hhsphsp..hhp..hht.....hhhlsspsGs.....psltculcphhpphthDtllhVDsGGDlLucGsEpsLtS...PL...tDuloLAuls.plpt......sshlsl.hG.GsD..G..E..LstshlLppluclspt..sGhLuhhul..sp.........p..s......s......p......h......l......cp....ll.......p...p.sso....E.A....Stl...s.......ht...Ah+Gh.aGph.....pl..Rsus..p..plhlsslsulhahhD.pt.l.hpts.hhphl..psotslc-Apphlp.thsh.oEhphE..h...t.....................	1	19	28	35
+6455	PF06627	DUF1153		Protein of unknown function (DUF1153)	Moxon SJ	anon	Pfam-B_21038 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	23.50	23.50	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.98	0.72	-4.12	22	282	2012-10-04 14:01:12	2003-07-24 10:47:34	6	1	259	2	92	204	26	84.70	58	93.15	CHANGED	Mah+KhpGP+tVsLPDGoshTpADLPPssT+RWVApRKAuVVcAVttGLlot-EAhcRYsLS-EEFtuWtpAlscHG.suL+sT.plQcYR	...................psp.+hVIGPDGoPLTlADLPPssT+RWVlRRKAEVVAAVRGGLLSl-EACpRYsLTsEEF.hSWQpuI-cHGhsGLRsTRIQpYR..............	0	24	58	71
+6456	PF06628	Catalase-rel		Catalase-related immune-responsive	Vella Briffa B, Coggill P	anon	Pfam-B_16304 (release 10.0)	Family	This family represents a small conserved region within catalase enzymes (EC:1.11.1.6). All members also contain the Catalase family, Pfam:PF00199 domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects [1]. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells [2].	20.90	20.90	20.90	21.50	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.86	0.72	-4.11	343	4316	2009-01-15 18:05:59	2003-07-24 10:55:15	7	11	2870	287	1207	3539	63	67.50	25	12.26	CHANGED	chctsp..D.pasQssthap.sh..sssE+p+llsshstpL....upsspt....lppRhls.hhtpsDsshuppVA.cuLs	..................p.tpt.-.pasQstthap.sh....sst....-....+p+.l.....hsshutpL....spls.ct......IppR.hls.hhtcs.DsshuptVAcsLt...........	0	326	674	986
+6457	PF06629	MipA		MltA-interacting protein MipA	Moxon SJ	anon	Pfam-B_8359 (release 9.0)	Family	This family consists of several bacterial MltA-interacting protein (MipA) like sequences. As well as interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex [1].	21.00	21.00	21.00	22.80	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.07	0.70	-4.94	16	1671	2012-10-03 17:14:37	2003-07-24 11:34:39	7	3	1070	0	339	1085	89	223.70	28	84.76	CHANGED	phslGs...uushssc..h.uu.cchpltshPhlshptts....hhhcssshuhtlhsssshpluhssthshstt.....csssptt........ptlss.................+cushssGlthth.hs.hplpsphp..tsl.ssscGhpsslshshshplu..phplssuhulsatsppasptYaGVssppuAtSsLsp.YsusuG.hsssluhsspYhls-phshtstsshoRLtusstcSPlVccchphshhhu.......hsYpF	........................................................................................................................................t.holGu...G..s.uhspp....acs....c..p.s..s.h...s..l..P..l..l.s..Ycu-s...............Fah.c.s.......h.....s........h.....G..a..h.L....h.....p..s..s.....s.....s..p.....lul..s.uh....a....ssh.th...........................cs.sc..ss.ctth..........................ptL-c.........................................Rc.u..oh..h.uG.l.u...h......t...a.....h...p......p.....a.G....h....l.c..s.s..hs.........sDs..h....s...s..u...s......G.......h....s.......h.......c.......h.u.hh...a.p.h.p....hu............sh......s...l.oPulGl..pasocs..hscYYYG.VoppE.u...s......+.........S........G.....l.....tu...Y.....s...s...s.s..u...as...sh..lp.lous.Y....s..hs....tc.....W.....s.....lhusupYo..+L.s.s-.l.s.D.SPh...V-...+....sh...sh...hh...ssG...loYcF....................................	0	55	144	243
+6458	PF06630	Exonuc_VIII		Enterobacterial exodeoxyribonuclease VIII	Moxon SJ	anon	Pfam-B_11449 (release 9.0)	Family	This family consists of several Enterobacterial exodeoxyribonuclease VIII proteins.	25.00	25.00	28.90	28.40	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.14	0.71	-4.95	4	316	2009-01-15 18:05:59	2003-07-24 11:35:34	6	4	227	0	12	263	0	174.40	44	23.76	CHANGED	huhh.hhhscKA+Kp.G..suhhWsoschEuss.ApLshhllcuGhc.sDahKsVtsNhPVVN-LPPEGphDhTFCp+YpLu.cDuhTahhIPGs..PuosAtDps....sssssTp...sGEDhTE....EEN..h.lS........stpLPlRahs.H.....hTasupDth.hhHlsRApc..tlTsLthspcsShlpsL	.......................................................shhs.hhscKs+Kp.G.KsuhhWsosch.Ssu.uphshhhscuGhc.....cDahKsVtsNhPVVNDLPPEG.hDhpFCsRYphu.cDuhThhhIs.hs..ss.s.ss.t-ps.......................ssss.NTs....hsuEDhoE............hE-s...h.lS.....................stpLPlRahs.H.....hT.asupDth.thHlspspc.ssVTALthspcsShLpsL................................................................................................	0	1	2	7
+6459	PF06631	DUF1154		Protein of unknown function (DUF1154)	Vella Briffa B	anon	Pfam-B_16329 (release 10.0)	Family	This family represents a small conserved region of unknown function within eukaryotic phospholipase C (EC:3.1.4.3). All members also contain Pfam:PF00387 and Pfam:PF00388.	19.80	19.80	19.90	19.90	19.30	19.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.33	0.72	-4.30	11	207	2009-01-15 18:05:59	2003-07-24 11:38:13	6	15	89	0	109	225	1	45.30	44	4.24	CHANGED	+c..shsPlslEsL+ppKuahKlhKKQQKEL-oLKKKHsKE+suhQK	........h......ltshslE-LKQpKualKlh...KKQpKELcsL+KK.HtKcpsshp.......	0	23	31	68
+6460	PF06632	XRCC4		DNA double-strand break repair and V(D)J recombination protein XRCC4	Moxon SJ	anon	Pfam-B_21077 (release 10.0)	Family	This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalysed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks [1].	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.14	0.70	-5.59	5	165	2010-01-05 15:47:52	2003-07-24 11:41:38	7	2	131	30	88	172	0	255.40	26	82.27	CHANGED	MERKVSRIsLoSEPslsaFLQVuWEKTLGSGFVITLTDGHSAWTGcVSESDISQEADDMAME+-KYVDELRKALVuuAGPA.....ssYsFsF.....SKEopaFSaEKsLKDVSFRLGSFcL-KVsNPAEVIRELICYCLDTIAEpQAKNEHLQKENERLLRDWNDlQGRFEKCVsuKEALEsDLYpRFILVLNEKKAKIRSL+.chLsElQEhEK..slKpKpETo.......ssSDposDcDulYD...GSTDEEsEuPsss.........................StpsPAsls+DDSLlSS.DlsDIAPSRKRRQRMQKNLGTEPKhAoQEpQhQEKEKsssusPposKK-tsSAEsMSLETLRNS.SP-DLFD	...............................................................................................................................................h.-s.s..sa.sphp.t.lt......ttt.t....tp...aht.htphh...t.ss............apht...............sp.p...ph.h.hc...K.ph..p..s.l....ph....RL..G.s.h.pLppstss.sp.hlp.........-.lhsas...lsshsc.ps..csp...c...L..pp....cs...-...+...L........p...-h...s...clp...sphE+hlssKcthEs-Lap+FlhVLNEKKsKIRsLp.ch...L.....sp.....sp...p..pc.....shppc..t.pss.................hps..c.sss.cc....s............D......t.o...s.c-c.p.pt.........................................................................................................................................................................................................................................................................................	0	20	38	62
+6461	PF06633	DUF1155		Protein of unknown function (DUF1155)	Moxon SJ	anon	Pfam-B_21101 (release 10.0)	Family	This family consists of several Cucumber mosaic virus ORF IIB proteins. The function of this family is unknown.	25.00	25.00	86.00	85.80	20.70	17.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.28	0.72	-4.69	2	5	2009-09-11 08:20:59	2003-07-24 11:44:03	6	1	1	0	0	8	0	41.00	79	91.52	CHANGED	MSATLSTTLSFEPPLSLLAEPGTWFADTMDFc+pp.lthhpp	MSATLSTTLSFEPPLSLLAEPGTWFADTMDFRKKHSVRWYpp.	0	0	0	0
+6462	PF06634	DUF1156		Protein of unknown function (DUF1156)	Vella Briffa B, Eberhardt R	anon	Pfam-B_16387 (release 10.0)	Family	This family represents a conserved region within hypothetical prokaryotic and archaeal proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	21.20	21.20	24.20	22.70	20.50	19.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.25	0.72	-4.22	43	252	2009-01-15 18:05:59	2003-07-24 11:47:17	7	11	214	0	122	263	47	69.50	31	7.82	CHANGED	sslPlcpIsttut+EKph..ppG.phosLHhWW.ARRPLuusRAllhAuLls.....................t.th-tpphhpll	.......shPlptlsttut+E+ph..ptu.p.psLHhWW.ARRPLussRAllhAsLls................................t.chp.h.......................................	2	53	89	106
+6463	PF06635	NolV		Nodulation protein NolV	Moxon SJ	anon	Pfam-B_21143 (release 10.0)	Family	This family consists of several nodulation protein NolV sequences from different Rhizobium species [1]. The function of this family is unclear.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.41	0.71	-5.16	2	48	2012-10-02 21:03:42	2003-07-24 11:47:37	7	1	43	0	13	247	7	191.10	32	93.17	CHANGED	MTADh.ssPAAPphRsLGPLIPAupLEIWcsAhpAhAAAERH.Q+VRuWARhAYpREhApG+sEGhpAGAEEMAtLIuQAssElApRKAVLEppLPQLVhEIlp-LLGAFDsGchLV.sVRHAIEppYpssEVCLHV.PhpsDhLApEFtsaDG.-GRP+lRIcsDPsLSscpCVLWSEaGNVDLGLsAQhRALRLGFG.LoEcuE.	..................................................t..h....................ll......As.pht.hh-Ah.thlsAA.+ccA..ppl+......spA..p.p......t.......aE...p.p.R..A....c....Gac-G.h...p.p...G........sc........c....h.......A..t.......L....l.......A..p....s.......s.....u....c....s.......s........c..h.h.......A.......s...L.......E...p....p....lsp.......L..V...lph....lRpl....L.G...t..h..D.....s..p...E..hll.+.s.lppAl...st.h.tps.p.p.lsL+VsP.s.c.V....-...hL....p.p.ph....s..p..h..s...s........s.h....p.l.pI...sDspLusspClLtophGsV-hGL-sQLcALRhuh..........t.......................................................	0	3	6	9
+6464	PF06636	DUF1157		Protein of unknown function (DUF1157)	Moxon SJ	anon	Pfam-B_21250 (release 10.0)	Family	This family consists of several uncharacterised proteins from Melanoplus sanguinipes entomopoxvirus (MsEPV). The function of this family is unknown.	22.70	22.70	23.20	475.70	18.10	22.60	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.27	0.70	-5.86	5	5	2009-01-15 18:05:59	2003-07-24 11:49:41	6	1	1	0	0	5	0	367.40	38	96.28	CHANGED	IYFV..IVGIIFlIaaIIasl....NpYlshhpNs.NaNhos.hhppls......lspc.hl-FhIIpGSh.-NlIlsRshDGlQslKlIPTFVFLoNalps-lIsYGGF.NsoLsFPsNNIhN+S.sWIYGGWFIluNGNGDaICV+SNN.sNI+RaNcscsllKaL..sYNsucsN.....DsIIloNIlYKhc.EIlLINIscIussNs.ss-YYsILGNILlYIKsNaINDKpFIIsGpsGLNSKYIpLAI-TIF.lDslISSCYDGuITYVcNN.lasQSSFIlIDKcLCPYGVRFGlRY.LENshspaNLlLYATIYNcNpcspplEYFNDcLSINIFESIKSpsNYsDcYVNW-cIDISsLssNFE.sslsLlDDss.oYo+cpL-sIlNK	IYFV..IVGIIFlIaaIIasl....NpYlshhpNs.NaNhos.hhppls......lspc.hl-FhIIpGSh.-NlIlsRshDGlQslKlIPTFVFLoNalps-lIsYGGF.NsoLsFPsNNIhN+S.sWIYGGWFIluNGNGDaICV+SNN.sNI+RaNcscsllKaL..sYNsucsN.....DsIIloNIlYKhc.EIlLINIscIussNs.ss-YYsILGNILlYIKsNaINDKpFIIsGpsGLNSKYIpLAI-TIF.lDslISSCYDGuITYVcNN.lasQSSFIlIDKcLCPYGVRFGlRY.LENshspaNLlLYATIYNcNpcspplEYFNDcLSINIFESIKSpsNYsDcYVNW-cIDISsLssNFE.sslsLlDDss.oYo+cpL-sIlNK...	0	0	0	0
+6465	PF06637	PV-1		PV-1 protein (PLVAP)	Moxon SJ	anon	Pfam-B_21397 (release 10.0)	Family	This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms [1]. The function of this family is unknown.	22.10	22.10	22.30	22.10	20.70	21.70	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.58	0.70	-5.91	2	56	2009-01-15 18:05:59	2003-07-24 11:54:25	6	2	31	0	29	44	0	320.80	46	79.83	CHANGED	MGLuM-+.usYARsGsppRGCWYYLRYFFLFVSLIQFLIILGLVLFMlYGNVHsoTESsLpATEhRA-uLYSQllGLoASQuNLoKpLNhohhsK-slMQ.hLssRR-h-RINASFRQCQGDhlhYhN.pRahAAIILSEKQCp-QhK-hNKoC-ALLFhLspKVKTLEhElAKEKslCoKDKESlLhsKR.sEEQL.tCsKsREhQpQEpQlscEpLpKVQuLClPLDp-KFphDlhshWRDSlI.RoL-sLsY..aa.LhsEhASlRRsC-phPulMooKlEELARuLRAsIERVsRENu-LpRQKLEhppuhpAuQEA+t+stpEAQAREspLpAECuRQTQLALEEKAsLRtpRDNLt+ELEt+KREhEQLRhElslR.SALDTClKsKS.PhhPs.Rs.GPsPNP.PIDPASLEEFK++ILESQR.Pss.PsA.sSG	.......................M-+.usY.R....sG.....s...ps+GCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNs.HsoT.E.upLps..TEpRA-sLhupllsLpuppsNLoK-LNlTspuK-ul.QhllssRR.......DL-RINASF+Q.CQ...s-hh.a.sp.+ahsAIlhSEctCtp..php-hNpoCpuhhhhLtpKsK..sl..EhEh.ppKhlCsK-K-u.hhhsKp.s.EpQhttC.sctpt.p.QEhQlsptpLppVpshChslDppKh..ph.plWR-Sll.+sLssh.....sa..ahs..s-.....h.tlp+.CcphPtlMtsKlppLAptL+hsItpVstENtclpRQK.thppshtuspctttt..pEsttp......phpt-ss+QspLALEEK.ssLpcc+-tL.+pLEt+c+phtthphplslp.tsL-sCl+sK..........................................................................................................................................................................................................................................................	0	1	5	12
+6466	PF06638	Strabismus		Strabismus protein	Moxon SJ	anon	Pfam-B_9849 (release 9.0)	Family	This family consists of several strabismus (STB) or Van Gogh-like (VANGL) proteins 1 and 2. The exact function of this family is unknown. It is thought, however that STB1 gene and STB2 may be potent tumour suppressor gene candidates [1].	25.00	25.00	28.40	25.90	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	505	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.80	0.70	-6.19	10	386	2009-01-15 18:05:59	2003-07-24 11:55:16	6	3	160	0	106	275	0	335.00	52	94.50	CHANGED	H+-R.pR-RH+s.pS+.....cspSRu-KSVsIss....P.spPhhsus.............sstpht.-sQDDNWGETTTAVTG.TSEcSISpEDlsplsK-hEDss.shsCcRYLGhulushLGLLAhlTPlAFllLPplhW..............R-cLcsCGssCEGLalSLAFKLLILLIuoWALFhRps+AslPRlFlFRALLllLlhLhs.hSYWLFYGVRlL.cu+........-csY+GIVpYAVSLVDALLFIHYLAlVLLElRHLQPtFslKVlRSTDGESRaYslGpLSIQRAAVWlLEpYY+DFPVYNPsL.sls.....KpRtuK+huGFKVYsV...DGs.ssss.suQSRAhlAAAARRRDsSHNEhYYEEAEaERRVRKR+ARLVsAVEEAFTHIKRh.........psE-p.....t.Psp.MDP+EAAQAIFPSMARALQKYLRoTRQQshHTMESILpHLAFCITHsMTPKAFLEpYLssGPTlQYs+-pttscpWTLVSEEsVTsuL+cGssFpL+psDFSLlVTV++IPal+LoEEaVDPKSHKFVL+LQSETSV	.....................................................................................................................................................TTA.........VT.G..TSE.tS.ShED.lu...p.hsh-.............pDo...s...G...h...s.C...pRYhGsTV.A....h.sL.uh..luFloPlAh....llLPpl.h.a..................h.p.L.sCsstCcGlhlSlAFKLllLhIGhWAl......F..h.R.....p.p.uslPRlFVFRAhhLVllhlhs.hSYWLFYhVpI....-up................sh.sYp....ul.V........pYssShsDsLlFIHYluVlLhEl.Rp....L..pPhahlKlVRSsDGESR.YslGpLSIQRAAlalLpp.YYp-Fsla................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	31	38	66
+6467	PF06639	BAP		Basal layer antifungal peptide (BAP)	Moxon SJ	anon	Pfam-B_21444 (release 10.0)	Family	This family consists of several basal layer antifungal peptide (BAP) sequences specific to Zea mays. The BAP2 peptide exhibits potent broad-range activity against a range of filamentous fungi, including several plant pathogens [1]. 	25.00	25.00	26.10	25.80	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.54	0.72	-4.27	3	15	2009-01-15 18:05:59	2003-07-24 13:29:27	6	1	4	0	4	14	0	74.00	36	76.60	CHANGED	MlLLASFVuHA+IISGETKEsSNTRSMTMT.TRuuuplIluDNKsuLCYLDuthLEYlC++Tp+CY+oLKcCLEaC	.............................MlLLAS..hVhHAphlsGps+EsoNstShTMT..T..puusphllu.....-scsulCYL....cuh.hhYsCc+Tp+CY+sls-CLt+C	0	0	2	3
+6468	PF06640	P_C	P_prot_C-term; 	P protein C-terminus	Vella Briffa B	anon	Pfam-B_16385 (release 10.0)	Family	This family represents the C-terminus of plant P proteins. The maize P gene is a transcriptional regulator of genes encoding enzymes for flavonoid biosynthesis in the pathway leading to the production of a red phlobaphene pigment [1], and P proteins are homologous to the DNA-binding domain of myb-like transcription factors [2]. All members of this family contain the Pfam:PF00249 domain.	20.00	20.00	20.00	28.60	18.80	19.80	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.74	0.70	-4.34	5	26	2009-01-15 18:05:59	2003-07-24 13:58:00	6	4	9	0	7	24	0	179.70	52	62.13	CHANGED	AIAIDMSKLQSA-+RRGGRTPGRSPKoSu............o+oKQsDsDpPGsEAtuss.............uAASSPR..HSDtAR..SsVVDP-..PNQPN.SSSGSTGss.EtssSuEDATGPWlLDPIELGDL.W.EAES...EMDALMsIGssupDuAslEGL-Al..sspAQVDDLF..DMDWDGFAAHLWGGPEQp.DHuA..plQQAAEPpssAu..........................tAuAAuAsuCoPDE+cLEAFEoWLLSDSF	............AlsIDhSKLQSA-+RRGGRTP..GpsPKuus............p+sKpsDsspPttcAt.uss.............uuASSPR..pSD.......VVsPs..sNQPN.SSSGSsGss.-tssSpEDAoGPWsL.-Pl.E.hGDL.W.EA-S...........EMDALhshGssu.DusslpGltsl..sspAQsDDLh..DMDWDGFAAcLWGsP..t...p+uu...lppAuEP.....................................sshusssD-..LEuFtoWLLSDSh........	1	0	4	7
+6471	PF06643	DUF1158		Protein of unknown function (DUF1158)	Moxon SJ	anon	Pfam-B_21508 (release 10.0)	Family	This family consists of several enterobacterial YbdJ proteins. The function of this family is unknown	25.00	25.00	31.80	83.20	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.92	0.72	-3.66	3	460	2009-01-15 18:05:59	2003-07-24 14:09:29	6	1	452	0	20	95	2	79.10	88	99.95	CHANGED	MKHPLETLlTAAGILLLALLSCLLLPAPSLGLTLAQKLVshFHLMDLNQLYTlLFCLWFLLLGAlEYYVIRFVWRRWFSLER	.....MKHPLETLhTAAGILLMAFLSCLLLPAPALGLTLAQKLVohFHLMDLSQLYTLLFCLWFLVLGAIEYFVLRFIWRRWFSLAD...	0	1	1	11
+6472	PF06644	ATP11		ATP11 protein	Moxon SJ, Hammonds G	anon	Pfam-B_21093 (release 10.0)	Family	This family consists of several eukaryotic ATP11 proteins. In Saccharomyces cerevisiae, expression of functional F1-ATPase requires two proteins encoded by the ATP11 and ATP12 genes [1]. Atp11p is a molecular chaperone of the mitochondrial matrix that participates in the biogenesis pathway to form F1, the catalytic  unit of the ATP synthase [2].	22.00	22.00	22.40	23.10	20.20	21.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.85	0.70	-4.90	22	313	2009-01-15 18:05:59	2003-07-24 14:22:25	6	7	259	1	214	313	1	231.70	28	77.06	CHANGED	hptppsshhc+YcsKlpphupppshpslp....cLcpthcp.............................ppt.tshsppspphpshct..s..s......st.ts...........KsLsShlclE+lcshstcE..lctlWcthat.....pcsslsAslP.h-pYcthhspA+psPhFlLPLPRp.................pGhEhaalQWp......................ssphlFTsLtpYKl+t-hAtPahslpaah-Lsp-KslVLMpGplpscst.............losp-AQhLh.slQpFY.............sttspp+hpLLcsFs+ts.pcFchpcllp.h	...............................................................t....t.h.t+YtpKl.phtpp..s......p....tlct.....................................................................................t...t..t.........t...................................s.....................................KsLsslhclchlcp.h.ss..cE...lptlWpthat......spps.lsAsls.sppapthhspAppsPhFllPLPRp............................pGhEhahhQat.....................................ssplhFTsLtpYp...h+s.-hAtsphslpaas..-.Lt..............c............pK.........GlVLMpGph...ssh..................lssp-AphLs.plQhFY....................tptsppphpLlcpFspts.ppFchppllpp.h......................................	0	68	118	178
+6473	PF06645	SPC12		Microsomal signal peptidase 12 kDa subunit (SPC12)	Moxon SJ	anon	Pfam-B_21331 (release 10.0)	Family	This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12).	21.40	21.40	21.40	22.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.54	0.72	-4.17	30	303	2009-01-15 18:05:59	2003-07-24 14:34:31	8	4	253	0	216	311	3	76.70	32	70.93	CHANGED	MDFpGQ+hAEplhplllslsulluhllGYhhQphuholalhhsGhslosllslPsWPh.Yp+pPlpWtpstsp.........sscp	..........hDapGQ+hAEplhphllhhs.............ul........l...uFlhGYhhpshphslalhhuGhslosLl..slPsWPh.Y.p..+pPlcWhsst.t......sptt...........	0	73	122	179
+6474	PF06646	Mycoplasma_p37		High affinity transport system protein p37	Moxon SJ	anon	Pfam-B_21350 (release 10.0)	Family	This family consists of several high affinity transport system protein p37 sequences which are specific to Mycoplasma species. The p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria.It has been suggested that p37 is part of a homologous, high-affinity transport system in M. hyorhinis, a Gram-positive bacterium [1].	20.10	20.10	20.20	22.00	19.60	17.70	hmmbuild  --amino -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.08	0.70	-5.41	6	52	2012-10-03 15:33:52	2003-07-24 15:07:28	6	1	48	5	17	60	2	353.50	34	84.94	CHANGED	sKFhcsaSpphs.KLccs........cVslohsh.lDDutoplsslposps..DFAFlsSpulso...Ns.pchsshlQTLTsuFKFDpshD.aYsDGs....LcphAcchsplFscs....P.YpsWsDEsQ............cWsGs+YpFlY..-P.scLlsFYRGMILIsGo-pplspIKcAWNpKNWssFpNaGIh.pGposSuG+ahL.-pLl+KHFs.tp.s..sLtpDhsssPsKYpssp...GR-IGpsssh+IsFDDtsSFAWTcNcpsups...YsPp.............pNsKlEILohT-PhlYDIGlFsKslspchtshIuEsFIpLAKsspDhYGPslGYNGY+hIsDFsKEVlclhpKAhG	............................................tFhc.hpppFN.cL.Kptp.tp+ph.cVphslps.spDp.pshlspL.psscs.....Dluhssssphls..........pspppsls..tl......QTt.ThtFpassss..sthYpDGs.p.pDsLRp......hAcctsclasch....s...YssWp..-pp...p............pasGs+Yp.hY....c.s...sc....lsp.aYRGhIhIs..G...s-..psppcIhKAW-sKcW-sFhpaGIl.au.cssSuGKY+hp.sLl++HFs...pphs......slpp....Dhp.pp.....spYhstt...........uspl..Gp..p..s....c.........h.......+......IuFDDE.G.S.a..u..WTcscpsupp.....apssc...................................................p.NsplchLTlTsPhsYD...lslh...c.p...u...lscpplcLloculhsLupsppso.YGshsGYN..tYp..hIps.p...hhp.htt................................	0	9	15	16
+6476	PF06648	DUF1160		Protein of unknown function (DUF1160)	Moxon SJ	anon	Pfam-B_21501 (release 10.0)	Family	This family consists of several hypothetical Baculovirus proteins of unknown function.	21.40	21.40	21.40	22.60	19.90	21.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.56	0.71	-4.34	14	51	2009-01-15 18:05:59	2003-07-24 15:13:58	6	1	49	0	0	44	1	123.50	30	93.34	CHANGED	FlsplhpshshssKVAhVstpLcpaLp-ht..pD-pFppKhhpllcMFlspcIsl-slhsllsuVDuh.cLTcpQI-YLssplatNppllpIlpsFl-tp+Ls---Is-lupFLVpElssAhhYp	..................................FhsplhpohshssKVuhVphplppaLp-hp...pDcsFppKhppllpMFlppclss-slhslhsssDsl.cLocpQl-YLhsplhpN..........splhpIlpp..al......c........tpc........L........sc--.lstlupFLVpchspA....t............................................	0	0	0	0
+6477	PF06649	DUF1161		Protein of unknown function (DUF1161)	Moxon SJ	anon	Pfam-B_21545 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	25.00	25.00	37.10	43.10	18.70	17.70	hmmbuild  --amino -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.46	0.72	-4.04	24	623	2009-09-11 10:51:00	2003-07-24 15:16:02	7	1	568	0	68	233	4	53.30	70	55.37	CHANGED	CEclKu-IptKI.ANGV..ouaTLEIVsN-pss..........ssupVVGpC-ssT+KIlYpR	.CERlpSDIsQRIINNGVPtouFTLoIVPNDQVD.Q................PDSQVVGHCANDTHKILYTR.	0	5	17	44
+6478	PF06650	DUF1162		Protein of unknown function (DUF1162)	Vella Briffa B	anon	Pfam-B_16458 (release 10.0)	Family	This family represents a conserved region within several hypothetical eukaryotic proteins. Family members might be vacuolar protein sorting related-proteins. 	20.30	20.30	20.30	20.30	18.70	20.20	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.96	0.70	-5.19	39	689	2009-01-15 18:05:59	2003-07-24 15:23:28	7	58	271	0	493	739	4	250.30	20	8.17	CHANGED	hplslauPYhllN+TuhsLthcscshttpstsp.s.............................chttPhhFSFsc.s...tpps+shl+lsc.op........WSp.....shShDulGsstplth.sssp.p...........................................tth....lGlslppGpGcYth...TKlVTluPRallpN+hs.slpltE.ss.........p.......ph....................h.pltssp..................................hhPhahh.ppstp.ppLs....l..ph.t.....ssp....WSusFtlscl.ushal+l..........................................hp..t...sstpthl+l-lhhcsuThFlphsstppp.hPaplcNh...o..............................cpp.hhaaQpss...p.................thp.hthplsPpshhsYAWD.Psutp	.............................................................................................................................................................................................................l.lhsPYhhlNcT.s..h...L.hp.t.p..t............t.........p..................................................................p...shha.......satt..p...........ptsts.lpl....sp.ut...........................................WSp..........h.uh......-....shu.......s.h.t.tlhh......t.tpt.......................................................................lG.lslp...upt....p....h........T+lVoh...s......P+allp.Nc..s....s.h.pl.phtp.ss............p......ph.......................................................h.plts.sp...............................................................................................p.h..sh.ah.......pt.s.tp....ph.lp..........l.....ph.t.......spp........................WS.ts.Ftls.c....ss.....h..hlpl.................................................................................................................................................................................................................................................................................................tpp.t...h...lpl-l.t...h.....p.....t................s.................o....h................h......l.php....p..p..p..t..........P.hhl.Nh...o..............................p...l.ahQt..........................................................h.l.Ptp....h.asWs.Phh..t..............................................................................................................	0	190	271	399
+6479	PF06651	DUF1163		Protein of unknown function (DUF1163)	Vella Briffa B	anon	Pfam-B_16509 (release 10.0)	Family	This family represents the C-terminus of hypothetical Arabidopsis thaliana proteins of unknown function. 	19.40	19.40	22.40	75.80	18.60	17.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.34	0.72	-4.43	6	20	2009-01-15 18:05:59	2003-07-24 15:30:57	6	1	2	0	17	20	1	68.50	55	39.95	CHANGED	hsGlIsKsIMcDIKERp-lRFGSRLhLPDCRcsTsGpMsYsCDEspLRFEPGSppKAThFsc.aPpChhl	.hsGlIsKcIMcDIKE++EV+FGSRlhLTDCRcsToGsMsYsCDEssLRFEPGSEhKAT.hFGs.aPpCh.h.......	0	6	6	6
+6480	PF06652	Methuselah_N		Methuselah N-terminus	Moxon SJ	anon	Pfam-B_3337 (release 10.0)	Domain	This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [1]. This family is found in conjunction with Pfam:PF00002.	21.50	21.50	21.60	21.70	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.64	0.71	-4.72	10	146	2009-01-15 18:05:59	2003-07-24 15:38:27	7	8	23	6	75	182	0	156.10	28	34.30	CHANGED	CsaaDTVsIScup+L.NGSYlYEsllIPA+LTGcYDF+llsDGs+hpVp.cHlRGCVCKLKPCIRFCCP+cplhss..upChsshs-..pLschc...Pal.slTLsDGSlsph.....+hps-hlVpp-..pP.C-cMasLsc.pphhDcaoL...........FENGolhR+hD.phhLsKpEYCLpPhpa...sssSl..cIhP+sC	.......................................CsahDTVslot....th..........suSY.apslllPsph..h..u...Ysa.hh...ts..p..s..pH.l.RGC....sCpl+sClRhCC.P.tphhst.....spC.sshpp....hhthp..shl.slT.h.s.sso..s.ph.....chhpchh.lppc...hP.Cp..ch..a....h...lsp........pasL...........a.ENGolh+p.D....p.thlspp-YClt.h.h.....sp...sh....lhsh.C.........................................................	0	14	17	58
+6481	PF06653	Claudin_3	DUF1164;	Tight junction protein, Claudin-like	Moxon SJ, Coggill P	anon	Pfam-B_21553 (release 10.0)	Family	This is a family of probable membrane tight junction, Claudin-like, proteins.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.11	0.71	-4.52	24	100	2012-10-03 00:20:40	2003-07-24 15:41:17	6	4	7	0	96	107	0	156.80	19	88.16	CHANGED	Mth...................lhhlshh..lhluhlhshlulFo.sWhs.psh.................shGllPa.s.....s......ahshuuhhhalohshhhhhh..lhhhhshtplp+pGastphRphFhhIuhhshllslLplsAhlLhulshsphttph...s.................tLGYSua.lslsoAllshsss...uLuhtl................ucpp.h...........p	............................lh.lshh..lhhuhl.LshlulF.o.....ssWhs.p..................................thGl.l.Pa.s...tt.s................Whss.suhhhhl...shshhhhhl...lhhhhhhhplhppshst.p...h.+..hhhhhlshhuhlhslhhhl.uhhlhu..ssh..sph.t..h.....................tlGa.ShW.lslsu...sl.lshhsh...hluhhh...........t......................................	1	31	34	96
+6484	PF06656	Tenui_PVC2		Tenuivirus PVC2 protein	Moxon SJ	anon	Pfam-B_15006 (release 10.0)	Family	This family consists of several Tenuivirus PVC2 proteins from Rice grassy stunt virus, Maize stripe virus and Rice hoja blanca virus. The function of this family is unknown.	25.00	25.00	1054.90	1054.70	16.90	16.60	hmmbuild  -o /dev/null HMM SEED	785	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.32	0.70	-6.75	5	33	2009-01-15 18:05:59	2003-07-24 16:25:15	6	1	6	0	0	34	0	784.10	74	94.19	CHANGED	lplSCstsssPC+psphLNGYYIEcGuICYN+AsINLaET..CFoGKYDp+lPVH..FSc...FGGpRYlcCDDEIlscso.LVGFpQscaTSKsLPINscNu-LVSYspuc.cuFhGlVYVEslcYC...spsscscpIlNcusuLph.slCpDGlLhuusSEC-lsVuETEFclPSCussKLPlYDDpIcVCpNssC+NVoCTsSslClsYDRMDFlhRlKNY-CS+oY+YalYllILllIIllChssIsIINILlhLKP...VFWLlKKllaulsGLCHR+PslpcsElDMupVRVV-Ds--GLLlsE-S+APNSNVs-plhpKAR+h-NGLIYIPYILhhLsLlhoous..CpDLVSSLSNIEVCsupsCcasSKlpLTLhNTPQDFCFKopSDVYKIRlspIoV+CLSRPLYYTNSYKRsIu+-DWKCFEG.cCosDsSpSIWDKS-S.LHYDYC.VsDFHlFSYC..PFYH.YNWKRIpYcPTS+LACoV+KCs-sQFEIsGYlo.KNGpVl+ElSGaoSsY-usIloIoLLSYNot+LP+EYVECDuKAYcRsuNDLGSFDKELhGSIQCPT+-DAhpLTsKCpTKlpul.EDpssIpY-EsDGlspLscTtoEPL+sVlVSpsGISLDThDlaPVTLoIpopccIoSIlTS+IShNsTsCcIKGVERKlKKTlI+VcosoKllLSDlLsCcDLAsCSLTFNs-....c+uECaTTSY+ssuoGssIpC+FlYSGDo...IhCKYsVSPl-IsVVSPplDloSF-uVKcSoQNWssFlh-hIRDNPKLTIVASILPIGhlLKTlKu	.VKVPCSARAPPCKLTYELNGYFIENGLICYNRASVNYFET..CYTGNYDYKLPLHPSFSK...FGGHVYLSCDDAILQNVS.LVGIQQTEYTSSPLLITNSNSEKISYSNLK.TGFLGIVYAVETRACIQPDQAKKPEEIINHGVAI..KPSCTDGVLYYINSACEVNVSDQTFSIPSCESVKLPTYDDTIEVCDKGGCQNVTCHPGEICDKYERMDMIMRIKNYQCSHIYRYSLYSIILFFVIVIVFTLITIMNILFFLKP...AFWLLKKVLYSMVGLCHRRPVVDEVSVDMSTVRVVDEAEEGLLVVEDSIAPNTNVSDKVKRKGRKVENGLIFIPYlLMILLLVCSAES..CQDLVSSISNIERCTNNSCDFISKMKLTLLNTPQDFCFKTSTDVYKIRFNSVRVMCLSVPLYYTNSFKRVISREEWKCFEGEGCRTDGTHSIWGESTS.LSFDYC.VTDFHIFSYC..PAYH.YNWKRIEYEPTSSRACTIMKCMDTKFEIVGYIQ.KNGHVLKELGGITSKYDSPLVSISLSNYNSARMPREYAECDGKAYLRTANDLGSFDKELLGNIQCPTKEDAVVLSSKCKTKILSN.EDLPVIRYlERDGVDMLEHVKSEPLKDVLVSSSGISLGTLDLFPVELNLQFKEAITSIITSKISLNGTSCKITGIERKFKKTTVSIESSNKVYLSDILACEGLAVCPMILNNI....KKGTCITTTYYSVTVGSMIKCKFIYSGDT...LMCKYDVSPLEITVISPSLDVSSFEAVKTSTTNWMELLAGIVKDNPKLSLVASIIPIGLILKTIR.S	0	0	0	0
+6485	PF06657	Cep57_MT_bd	DUF1167;	Centrosome microtubule-binding domain of Cep57	Moxon SJ	anon	Pfam-B_9878 (release 9.0)	Domain	This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, Pfam:PF14073, is the centrosome localisation domain Cep57 [1].	24.40	24.40	25.10	31.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.41	0.72	-4.03	29	210	2009-01-15 18:05:59	2003-07-24 16:32:35	8	7	119	0	127	209	0	76.60	34	11.72	CHANGED	pcsohpsutsstpuL...upllptLpDEhsHhphchpcLtt.hpplDsohspcpRcpLtpclcpLlcclEtKu-QIhpLhcl	.....................s.psSpuss-sL...u-lLpsLQDEhspMsh..-HppL...h+plpc...o..spch+csLcpELEpLlc+MEtKucQIsKL++h.....	0	27	44	77
+6486	PF06658	DUF1168		Protein of unknown function (DUF1168)	Moxon SJ	anon	Pfam-B_9807 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function. 	22.10	22.10	24.30	24.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.20	0.71	-4.67	36	257	2009-01-15 18:05:59	2003-07-24 16:56:40	7	5	228	0	194	254	3	141.50	35	69.22	CHANGED	Pc+thtlPctscphs.t.....ssPEhVpNV.GSSAGAGSGEFHVY+ptRRREYpRlchh-cpsc+-ppscpappKpcEpcctsEEKTtK+RtKRpK+KpKpppt+ptcpts................ttppspppspssssssccs...........t...tsthtsc	...............................p+.h.lPpt.pp.hs.p......ssPEhVpNV.GSSAGAGSGEFHVYRphRRREYpR.chM-ppsc+cctcpEFpp+hccpcptsEE+TsKpRtKRpK+Kp++ttt+ptptpp..............................tttt.tttttpt.ppttpttptt.......................ssttt.t...................................................................................	0	68	105	155
+6489	PF06661	VirE3		VirE3	Vella Briffa B	anon	Pfam-B_16550 (release 10.0)	Family	This family represents a conserved region within Agrobacterium tumefaciens VirE3. Agrobacterium tumefaciens (a plant pathogen) has a tumour-inducing (Ti) plasmid of which part, the transfer (T)-region, is transferred to plant cells during the infection process. Vir proteins mediate the processing of the T-region and the transfer of a single-stranded (ss) DNA copy of this region, the T-strand, into the recipient cells. VirE3 is a translocated effector protein, but its specific role has not been established [1].	19.50	19.50	22.90	24.00	18.50	17.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.95	0.70	-5.31	4	15	2009-01-15 18:05:59	2003-07-25 11:30:11	6	1	9	0	3	14	0	270.50	55	49.60	CHANGED	psRLEsP.+K+KYsuDhpllsKLDsGFRGEIuYKlhGNcpLRlDpspELT+E+Gll+KTKpVLKRsssTGplYLuhHERKoWsSVooHpYupDGoLRtKHVKYKDGRFEE+WERDEsGsLlRTRYhNRGRLssthh+PlSEEhuAPYcSGs-pRLYRcLTRQsGS++ETFERDDKGNLELlupKRhGFS+pohKutDRpTSpTpIRKLGGAFSKSYRSLLDKEGNElGRDllSHRRLaNKRSAlYD-uTGQLKShKHTFGKIYKuEupYLsAclKcVSKKILGVTVtR+LssLSEcEhpAp+LRshEsutH+QAWQc	...........ARLEsPppK+KYsuDMpllDKL-sGFRGEIuYKhhGNcpLRlDsspELT+E+Gll+KT+cVLK.RsspTGsVYLuhaE+KoWtSV..oSH.YupDGoLRsKHVKYKDGRFEEKWERDEsGtLhRTpYhNR.sRL....FpPlSEclusPYcSGs-NRLaRcLTRppGS+pETFERD-KGNLELIGpKRhGFS+sSsKu.DRpTSpTpIRKLGGAFSKSYRSLLDpEGNElGRDI.SHRRLhNKRSAlYD-uoGQLpSsKHTFGKIYKSEotYLsAclKcVSKKILGVTVtR+LssLScpEh-AQ+LRstEustH+pAWQc.........	1	0	2	2
+6490	PF06662	C5-epim_C	C5-epim_C-term; 	D-glucuronyl C5-epimerase C-terminus	Vella Briffa B	anon	Pfam-B_16571 (release 10.0)	Family	This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyse the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.19	0.71	-5.01	18	182	2012-10-03 02:33:51	2003-07-25 13:05:58	8	7	150	0	112	191	17	180.00	42	36.94	CHANGED	Q-.ppGuWshshshphhps.t..LssGWhSAMuQGpAlSlLsRAYphTp.DpcYLsuAt+Als.aplsspcGGlhsshhsh......hsWYEEYs.....ToPsoaVLNGFIaoLlGLYDhs.............stphsscApplFppGlcSLKthLshaDs.GshohYDLpahs.hspsPsluthpYHshHlp.LphLhsIs.s..-.happhhc+Wpu	................................D.ppGGWsh.VpRplh.psht..LpsGWhSAMAQG.........pAlSsLs.RAYhhTp.DcpYLpuAh+Ahtsa+hs...upp..sGVhuh.Fhsp.............asWYEEYP.....TsPsSaVLNGFhYSLlGLYDLpp..........sstphuc-A.ppLappGhcSLKthL.PLYDT..G....SsohYD...LRHhh......lshuPNlAphcYHshHlpQL.hL.sls.p...s.hh..tphsc+Wp.........................................	1	36	52	86
+6491	PF06663	DUF1170		Protein of unknown function (DUF1170)	Vella Briffa B	anon	Pfam-B_16582 (release 10.0)	Family	This family represents a conserved region of unknown function within MAGUIN, a neuronal membrane-associated guanylate kinase-interacting protein. This region is situated between the Pfam:PF00595 and Pfam:PF00169 domains [1]. All family members also contain an N-terminal Pfam:PF00536 domain.	21.90	21.90	23.60	24.40	17.10	16.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.12	0.71	-4.37	6	166	2009-01-15 18:05:59	2003-07-25 15:36:33	8	13	39	0	95	132	0	172.60	47	23.89	CHANGED	huss..oK+-ssAlpDLYIPPPPutPYoPRDEpGshss-sts+.ph.shsVsKGSESPNSFLDQEsR+R.FslsEpDplsashph-psh.hss+hR-sTPTYG+LRPISMPsEhNWhu-s-D.uKh+RpuR.pEsSLhRYhS....s-+Is..sEE.......ahhuRsusccphhR............................u++KScpusosu...chSLLsSh	............................h.sossK+-psAl.DLYIPPPPu..PY......PR.DEpGshsspshpp..ph.shPstKGSESPNSFLDQE...R+R.Fsl.s-.pDpl..sYph-psh..stth.REpTPoY...G.K.R..PlSMPs-hNWhGth-s.s+.+t.cuR...t...EsuLhRYhS....NE+Is..tEE.......a.hhpRsspccphh+................................................sKKKutpuso.o...c.SLLsS..............................................................................................................	0	2	8	50
+6492	PF06664	MIG-14_Wnt-bd	DUF1171; MIG-14_Ce; 	Wnt-binding factor required for Wnt secretion	Vella Briffa B, Pollington JE	anon	Pfam-B_16593 (release 10.0)	Family	MIG-14 is a Wnt-binding factor. Newly synthesised EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion [1].	20.90	20.90	21.10	21.10	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.80	0.70	-5.59	15	334	2009-09-13 15:31:17	2003-07-25 16:08:38	7	4	113	0	203	313	0	260.00	30	52.85	CHANGED	tpC-plslhclGhLcaspYllslphss.p.h.............plp.slphphhphNssFTpl.lhh+hlFhlhohlhhshFsppl+plshpsWhlEQKhhshLhslLllhNsPhahhslhhsssahllLsslhQulFhshLhhFWLlhhcplhl...pspRcsl+s.YhsKllhlsllhlshllhshhp+sppLcDPhaShhssshshpshhsahhlsslh...YlLaLlahIl+sasplcspth..h.....................................................Ra+alhlhslhshshsllhhhhs...........hsph.thtpo..SApFhshYulhNlYlasltalYuPScp	.......................................pCs.l.hhclG.lsap.Yhlslph.s.pph...................plp..slp...h..h...hhp..NsuFop.l.lhh+hhhhsh.s.hllh.....sh.....a..h.+..pl..............p.hhs.h.s...hhlE..Khh.hLh.hhhhhN.....Ph..h.ohhh....s.....h.h.....hh..h.sslhQuhF.hshLL.FWl.hhht.....thhh............ptp+.p.plp.......h..Yh......p.....lhhlshh.hshhhhshh....p....pss.p.LpsP.hYphhss.shsh.p.hh.....hhFhhlsshh......Yhla..Lhahlhpshpplpth.....l............................................................................RhKFLhhhohh..shsholhhhhhp..h.th.....................t..hs.......h.sh..s........uu.FhuhYGhhNhYlaslhhlYuPut.....................................................	0	98	111	160
+6494	PF06666	DUF1173		Protein of unknown function (DUF1173)	Vella Briffa B	anon	Pfam-B_16904 (release 10.0)	Family	This family contains a group of hypothetical bacterial proteins that contain three conserved cysteine residues towards the N-terminal. The function of these proteins is unknown.	25.00	25.00	31.70	30.70	18.30	23.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.20	0.70	-5.63	17	141	2009-01-15 18:05:59	2003-07-28 10:16:29	6	2	109	0	50	143	15	350.90	28	91.03	CHANGED	patlsspshst........sssplQshLspAappttR...PhCLC..p..tssltMYlA+hs.sp.allKRMPtoGtcHss..uCsSYEss.phSGLGtlhGsAlp-.scsGpssL+lsFuLo+tssRss......Psupsst..ss.slcsssp+loLRuLLHaLW-cAtLscWsPshsGKRsWuhVRphLLpAAcphps+uhsLu-hLaVPEsFps-pKstlupR...RpstLushth..t.Gpp+hhlllGElKphssuR....Gc+lsl+Hh.PshP..hhlcschacRlt+pFssELchWcuspst.....+LlsIAphs....hsssGhspl--luLMhVoEpWIPhEostEt.LlctLssp+RRFlKsLRashssstPhssslLhDspspssuhalVsutsspca..ctslcchl.scsthss..WhWcsup	....................................tt.s.th.pthLtpAa.t..ppt.p......shChC.....p..pss.....h.hhl..tph.......s...sp...ahltRhPsoGtp...H..ss..sCs.ac......sssch.SGhu..........t.hhusslpt.spsGphsl+LshuLscts.spts............stststt....t..ss.pss..tpphoLhulLchLWppAtLspWtPshs.G...+R.shsh.V+ttLlpAApphtsp.tt....s.LschLal.t.aps....pp+ptlttc............ptthluphth....ts.pchhlllu.lpchsss+h.....upp...lsl+ph.ss...hs........hhh..spshac+lp+RFstE...LthWpssp............+llslut.hs............hstsuhspltcluLMhVo.cp.WIPh-osaEhhlhcpLstppRpFlKsLRashsts.........tshsshhLhDst..t......s.sshh.V.u.hs.s..pa...cpthcphh...spphhss..W.hWcst.t..................	0	8	21	39
+6495	PF06667	PspB		Phage shock protein B	Moxon SJ	anon	Pfam-B_21806 (release 10.0)	Family	This family consists of several bacterial phage shock protein B (PspB) sequences. The phage shock protein (psp) operon is induced in response to heat, ethanol, osmotic shock and infection by filamentous bacteriophages [1]. Expression of the operon requires the alternative sigma factor sigma54 and the transcriptional activator PspF. In addition, PspA plays a negative regulatory role, and the integral-membrane proteins PspB and PspC play a positive one [2].	24.30	24.30	24.40	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.59	0.72	-4.04	36	768	2009-01-15 18:05:59	2003-07-28 11:43:46	7	3	748	0	106	251	47	74.20	63	97.85	CHANGED	Ms...h.hlhsPlllFhlhVAPlWLlLHY+oKppsupGLopc......-pppLppLhppA-+Mp-RlpTLEpILDAEsPsWRp+	.....................................MS..ALFLAIPLTIFVLFVLPIWLWLHYS...N.R.u.s.p...up.L..S.Qu......E..Q..QRLtQLsD-AcRMRE..RIQALEsIL.DAEHPNWR-..............	1	20	44	74
+6496	PF06668	ITI_HC_C	ITI_HC_C-term; 	Inter-alpha-trypsin inhibitor heavy chain C-terminus	Vella Briffa B	anon	Pfam-B_16674 (release 10.0)	Family	This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix [1]. All family members contain the Pfam:PF00092 domain.	21.50	21.50	22.50	21.50	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.07	0.71	-4.88	29	404	2009-01-15 18:05:59	2003-07-28 12:08:42	7	13	48	0	193	292	0	177.50	33	20.30	CHANGED	soGlsVNGQlIGsct..s.tp+pcTYFupluIshpp.chp.lElTspplsl.cuppp.shsWp-osslspsulplols+ppslsVolsssloFsllLH.phhKtpPhppDaLGFYlhsoc+hSupsHGLLGQFhpt.-hclhchhsGsDspK...............s-AohpVKucplsVTRthpKDYppc....GppVsCWFV+N	.........................................................oGlpVNGpllGs.t....tppppTYFuplslhhpp........c..hp...lElo..scp.Isl....p.G....spp..shsWpcosh.l..t.p.....ss...lplo...ls.....+pps..lsl...olscslsFsl.llH.phh+.p............sh..........pp.-aLGhYlhso.cphSspsHGLL.G...........Q..........F...hpt.chclhs..sutssp+...............scA..shhVKupplsVT......Rt.p+DYpps.....Gp..plsCWFl+N........................................	0	19	28	87
+6497	PF06669	X_fast-SP_rel		Xylella fastidiosa surface protein related	Moxon SJ	anon	Pfam-B_21796 (release 10.0)	Repeat	This family consists of several Xylella fastidiosa surface protein specific repeats which are found in found in conjunction with Pfam:PF05662, Pfam:PF05658 and Pfam:PF03895.	22.60	22.60	23.60	22.80	21.70	22.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.36	0.72	-4.04	2	73	2009-01-15 18:05:59	2003-07-28 12:12:23	6	31	27	0	9	81	0	68.30	60	6.35	CHANGED	NAVQsQASQPVTFoGNEGuVKRoLGQuVVISGESSTAGTYSGGNLKSVVDEAAGtIHLQLADSPKFGNVl	.........NAVQsQASQPVTFoGNEG.o.VKRoLGQuVVISGESST.A.G.TYSGGNLKSVVDEAAGuIHLQLADSPKFGNVl................	0	3	8	8
+6498	PF06670	Etmic-2		Microneme protein Etmic-2	Moxon SJ	anon	Pfam-B_22009 (release 10.0)	Family	This family consists of several Microneme protein Etmic-2 sequences from Eimeria tenella. Etmic-2 is a 50 kDa acidic protein, which is found within the microneme organelles of Eimeria tenella sporozoites and merozoites [1].	21.90	21.90	238.40	64.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.40	0.70	-5.75	2	8	2009-01-15 18:05:59	2003-07-28 12:17:37	6	2	2	0	0	10	0	302.50	73	99.96	CHANGED	MARALSLVALGLLFSLPPSSAVRTRVPGEDSFSPESGVLSGTDAPERRP..............lVPGLsEGNCGRLTVRNGLSVDETIKVTSAGWTKSERDFIVSLVADETRKVVQLRESEGASGASGPGPAPAEKPPSGQGSAEEAPKGEGGQEKPSVPLIAVRIHGSGGDKGESAPQSAVLLYGNDESEPTEVPLETAAGPTTPLMVLITQQNPKEVEVRVLAWIST.......................DATTGKGSWKENSVVVGSSLSGRDLTVNLSDCGPSSLRVYGSASADLVTVKEGMCEADDPELIALTRPHTSAASPLPAEEGDVAQDAQQSAGAQQEAEsQEVGEPQQEAAAAEQGSSAAESDTQQSS	...MARALSLVALGLLFSLPPSSAVRTRVPGEDSFSPESGVLSGTDAPERRP..............lVPGLVEGNCGRLTVRNGLSVDETIKVTSAGWTKSERDFIVSLVADETRKVVQLRESEGASGASGPGPAPAEKPPSGQGSAEEAPKGEGG.QEKPSVPLIAVRIHGSGGDKGESAPQSAVLLYGNDESEPTEVPLETAAGPTTPLMVLITQQNPKEVEVRVLAWIST.......................DATTGKGSWKENSVVVGSSLSGRDLTVNLSDCGPSSLRVYGSASADLVTVKEGMCEADDPELIALTRPHTSAASPLPAEEGDVAQDAQQSAGAQQEAEAQEVGEPQQEAsAAEQGSSAAESDTQQSS.........	0	0	0	0
+6499	PF06671	DUF1174		Repeat of unknown function (DUF1174)	Moxon SJ	anon	Pfam-B_22180 (release 10.0)	Repeat	This family consists of a number of Caenorhabditis elegans specific repeats of around 36 residues in length which are found in two hypothetical proteins. This family is found in conjunction with Pfam:PF00024.	19.70	10.10	220.50	10.10	15.30	10.00	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.33	0.72	-4.31	36	528	2009-01-15 18:05:59	2003-07-28 12:22:07	6	7	5	0	394	512	0	23.10	67	46.28	CHANGED	SGEETTTuAVTEASG...EETTTu...AVTEu	.....sctsTs..uA.......VTEASG...EE.oTTu...AsTEu........	0	67	130	394
+6500	PF06672	DUF1175		Protein of unknown function (DUF1175)	Moxon SJ	anon	Pfam-B_21722 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 210 residues in length. The function of this family is unknown.	20.60	20.60	20.60	20.60	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.42	0.70	-5.00	13	358	2012-10-10 12:56:15	2003-07-28 13:11:22	6	3	342	0	32	141	11	193.80	79	93.81	CHANGED	.hhhthpspssstcucs...thLssppStsFRsWFVRIAppQlRps.ss+W..cp+DCAGLVRFAspEAL+tHDucWhcssGhs........s+Yh.PchsL.usphhhtpphp.....pssGp..husassAhsLlppNo+Flu+D...lspApPGDL.lFFcQtDsp...HLMIahGc.........allYHTGshsc.s-stlRsVolppLhpa.DscWpPhssNPsFlGlYRhsFLs	............................tlLhLlsalsCsV.............AHS...EMLNVEQSGLFRAWFVRIAQEQLRQG.PSPRW..YQQDCAGLVRFAANEs.LKVHDSKWLKSNGhS..................SQYLPPEMTLTPpQRQLAQNWN.....QGNGK..TGPYVTAINLIQYNSQFIGQD...INQALPGDM.IFFD.QGDAQ....HL.MVWMGR.........YVIYHTGS........A...TK.T..........DNGM.RAVSLQQLMTWKDTRWIPNDSNPNFIGIYRLNFL.A......................	0	10	15	25
+6501	PF06673	L_lactis_ph-MCP		Lactococcus lactis bacteriophage major capsid protein	Moxon SJ	anon	Pfam-B_21754 (release 10.0)	Family	This family consists of several Lactococcus lactis bacteriophage major capsid proteins.	19.40	19.40	20.10	19.60	18.00	18.80	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.11	0.70	-5.67	2	7	2012-10-03 06:22:39	2003-07-28 13:15:30	6	1	7	0	0	9	0	346.70	95	81.31	CHANGED	MGsNETQEhMKQAIEAGVKVRELEsKVEELNKEREELKKEREAsIPSEKPpDsERKFMRELGsKMsEMPEQGFLREFANuusLNVVNSLGSITSKYARKSGIYDGAMKARFQGLTLAEDGVDDTFIpGTFKAGTDKNKuQTAoKRSLRPQMAEAYLQMDKATVRGVNDSGALSEYVMSEMVNRVIQKVEaNMILGSsDGSNGFYGLKTATDGWTKQIEYTDLF-GITDAVAECSISDAITIVMSPQTFAELRKAKGTDGHSRFNELATKEQIAQSFGAVNLETRVWMPKDEVAVYNHDEYVLIGDLNVENYNDFDLRYNVEQWLSETLVGGSIRGKNRSAYLpKKuS	................................MGANETQEIMKQAIEAGVKVRELEAKVEELNKEREELKK.EREASIPSEKPQDsERKFMRELGDKMsEMPEQGFLREFANuuDLNVVNS..LGSITSKYARKSGIYDGAMKARFQGLTLAEDGVDDTFIpGT.FKAGTDKNKuQ.TATKRSLRPQMAEAYLQ..MDKATVRG..VNDSG.ALSEYVMSEMVNRVIQKVEYNMILGSADGSNGFYGLKTATDGWTKQIEYTDLFEGITD..AVAECSISDAITIVMSPQTFAELRKhKGoDGHuRFNELATKEQIAQSFGAVNLETRVWMPKDEVAVYNHDEYVLIGDLNhENYNDFDLRYNVEQWLSETLVGGSIRGKNRSAYLKKKuS..........	0	0	0	0
+6502	PF06674	DUF1176		Protein of unknown function (DUF1176)	Moxon SJ	anon	Pfam-B_21791 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 340 residues in length. Members of this family contain six highly conserved cysteine residues. The function of this family is unknown.	34.80	34.80	35.00	35.10	34.50	34.70	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.28	0.70	-5.33	26	714	2009-09-11 20:41:29	2003-07-28 13:20:13	6	5	643	0	80	389	14	321.60	47	92.18	CHANGED	lshsshsss.....shthpacDWpVsCDNspsCpAsuhsscp.s.........lslhlpRpAGssssl.phclph.up.tts.........stthpLhlDGcshuhhssphptt.t..................phsssplsAlLpslppupplslt..sust.......hplShsGhsAuLLhhD-hQuRlGTssAllcK..GspPssuVssAsshPsl..ssssssst.....shstpptpthtpssh..........hpsspsp..tttssh..pst................lstLssspsLlhhsC.hsGAYN.ps.shWllscp.............tshpsphlshp..................sssas..suplsshtKG...RGluD.CGstspWha....DGpp..FhLsptsppupCcshtuus.....sW.hsahsp	............................................................hs..hphlWAA......PuQ+sFuDWQVTCNNQNFCVARNsG-HpG..........LVMTLSRSAGA+TDA.lLRI-t...GGltsPcAp.....cutIAPRLL.LDGcPLu.h..sus+W+loPahLh...............TsDsATITAFLQhIQ-.up.AITL+..sGsQ........TlSLuGLKAALLFIDAQQKRVGSETAWI+K..GsEPPLSVPPAPALKpV..Al.lNPTPs.....PLS.E.ERsDLLDYus............WRhNGhc..CS..LDPLRREsp.................VoALTDDKA..LhhlsC..EAG...AYN.TIDLAWlVSRK.............Ksh.so.RsVRLRL.......PFssutEos-........hELMNAsFDEKoRE..L..V..TLAKG...RGLuD.CGIQsRWRa....DGpR....F.RLVRYAsEPoCDsWHGPD....AWPTLWIT.R.......................................	0	9	26	58
+6503	PF06675	DUF1177		Protein of unknown function (DUF1177)	Moxon SJ	anon	Pfam-B_21818 (release 10.0)	Family	This family consists of several hypothetical archaeal and and bacterial proteins of around 300 residues in length. The function of this family is unknown.	25.00	25.00	63.10	62.90	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.76	0.70	-5.81	22	133	2009-01-15 18:05:59	2003-07-28 13:23:24	6	2	116	0	50	126	4	262.00	54	88.23	CHANGED	clpplss......pGsTDFl+lhlsGptG+..GGsAPTlGIlGRLGGIGARPpphGLVSDADGAlsAlAsALKLhcMpc+GDhLsGDVllsTHICssAsshPHcPVsFMsSPVshspMN+pEVcPph-AILSIDTTKGNRllpa+GFAIoPTlKEGYIL+lS--LlcIhphsTG+.shshPlTpQDITPYsNslYHlNSIlQPs.lsTsuPVVGVAITucssVPGsuTGAoc.sDl-pAuRFslEVAKtaspGpscFYDppEatcLpphYGshspLQphGcp	...................p.hpplpup.....pGsTDFl+lhIPGppG+.tGGsAPTLGIlGRLGGIGARPphlGhVSDuDGAlsAlAsAhKLhcMpp+GDhLsGDVllsTHICPcAPTpPHcPVsFMsSPl-htsMNcpEVs.sphDAILSlDTTKGNRllN++GaAlSPTVK-GYIL+lS--LLclhphsTGc.shsaPlTpQDITPYGNGlaHlNSIlQPu.sATsAPVVGVAITopssVPGCuTGAoH.sDlstAsRFslElAKtFGpGpspFYDppEappLhphYGshs+LQshGp.t....	0	12	25	39
+6504	PF06676	DUF1178		Protein of unknown function (DUF1178)	Moxon SJ	anon	Pfam-B_21872 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.	26.50	26.50	26.90	30.90	24.20	26.40	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.99	0.71	-4.00	79	438	2009-09-13 03:22:43	2003-07-28 13:25:38	6	3	420	0	154	372	1244	143.00	40	98.30	CHANGED	MIhasLpCs.psHpFEuWFtSussF-sQtspGLVsCPhCGSspVpKslMAPplssuppt.....................tssPssssssts............................pttltclpccltpso-.VGccFAcEARchHh.GEsscRsIaGcAos-EActLlEEGIsVhPL..P.....hsscpp...s	...........MIhasLpCs.pu.HpFEGWFtSus-F-pQtpptLVsCPsCGospVpKtlMAPplstupsptt...............................................s.sh.t.t....................................................ttl.tthtpht+pVhpss-.VG-+FA-EAR+IHa.GE.s..tRuIhGpAos-EscsLhEEGI-lhPL..P...h.st...t....................	0	37	91	118
+6505	PF06677	Auto_anti-p27		Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)	Moxon SJ	anon	Pfam-B_21881 (release 10.0)	Family	This family consists of several Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) sequences. It is thought that the potential association of anti-p27 with anti-centromere antibodies suggests that autoantigen p27 might play a role in mitosis [1].	23.20	23.20	23.20	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.23	0.72	-4.19	14	282	2012-10-03 10:42:43	2003-07-28 13:32:39	7	6	238	0	193	271	18	40.90	37	20.80	CHANGED	cl.cphuchLhpGApMLscpCspC.GsPLFc..KsGclaCPsCp	....t.h.phhuchLLpGhpMLscpCs..p..C....G..sPLh.......c.......+.p.G.c.h....h...CssCp.......	0	83	124	160
+6506	PF06678	DUF1179		Protein of unknown function (DUF1179)	Moxon SJ	anon	Pfam-B_21899 (release 10.0)	Family	This family consists of several hypothetical Caenorhabditis elegans proteins of around 106 residues in length. The function of the family is unknown.	25.00	25.00	27.10	26.00	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.54	0.72	-3.72	4	16	2009-09-10 23:27:31	2003-07-28 13:37:01	6	1	4	0	15	15	0	97.00	34	92.33	CHANGED	MaSFshIhcsIsL.FGs.FLLlssllpCp..SKKKF+sDt+scLV.....uPhppssscpspt.tsPsuQsPPs+hPhEpospht.....-DTLANV+SlPPcpp.t.ct.chKpKp	.......................h.hlhpplhL.....hlLhhsll.pCp..pKKKFcsDt+ApLV.....sPss.sssc....ssps.psPsuQ.........sPPs+pPlEposp.t.....EDTLANV+SlPPEKS...pp.chKh..t.......	0	7	7	15
+6507	PF06679	DUF1180		Protein of unknown function (DUF1180)	Moxon SJ	anon	Pfam-B_21907 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins of around 190 residues in length. The function of this family is unknown.	24.80	24.80	24.80	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.14	0.71	-4.35	7	117	2009-01-15 18:05:59	2003-07-28 13:39:38	7	1	66	0	80	126	0	144.30	30	90.58	CHANGED	M......uhhs.h.ssshLLhLLs.L...sulhpcAssAss.....pPtspp.s..PPuPosu.......................Psuh..hts.tGssussSsGusLss..sss..spPhhpRALhVhsshSAhlllYFllRshRhR+Rp+KTRKYGVlcTshtshEhsPL.EpDDEDDD.TlFDhp..RR	.......................................................................................................h.t......................................................................................ssst.......................................sst..................tstt...s.p...s.s.s.ssslhsp.s..s.......h......-h...s.h.hp...pul..hVlhuhouhlllhhll....R.shRh+....+.+t.......+K..oR........+YGllsss...-shEhs..PL...-pD...DE--DpTlFDsph........................................................	0	15	19	43
+6508	PF06680	DUF1181		Protein of unknown function (DUF1181)	Moxon SJ	anon	Pfam-B_21912 (release 10.0)	Family	This family consists of several hypothetical proteins of around 120 residues in length which are found specifically in Trypanosoma brucei. The function of this family is unknown.	25.00	25.00	167.70	167.00	17.70	16.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.69	0.71	-4.43	2	14	2009-01-15 18:05:59	2003-07-28 13:41:54	6	1	3	0	10	14	0	112.40	87	82.70	CHANGED	MFQLVSssEVNKAYVSYPGGVSMCLRFPFCHCVWAHAMTLIEISGHYHRWVARGtSEDWDYSNSFVVVCsVLLENIAssEREGKCHLTFHAATSMH+sYMLVALpGKsVKAKVSFRF+EV	....MFQLVSsAEVNKAaVSYPGGVSMCLRFPFCHCVWAHAMTLIEISGHYH+WVARGESEDWDYSNSFVVVCsVLLENIAsNEREGKCHLTFHAATSMH+sYMLVALpGKVVKAKVSFRFKEV.	0	0	10	10
+6509	PF06681	DUF1182		Protein of unknown function (DUF1182)	Moxon SJ	anon	Pfam-B_21992 (release 10.0)	Family	This family consists of several hypothetical proteins of around 360 residues in length and seems to be specific to Caenorhabditis elegans. The function of this family is unknown.	25.00	25.00	26.60	26.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.66	0.70	-5.14	2	21	2012-10-03 04:04:29	2003-07-28 13:44:35	8	1	6	0	20	18	0	203.70	36	63.80	CHANGED	h.N.......................NhsLsslTsTPhTYRDRIhhEF.lpuTshlFshhLsIFhhhR.tlhhohKsTIhFVTLGoFlLslPLhhhQhahVh.L.uhhpPhYTlhVCohlKshsSSTTSshQVLPhAVulYRYhhVVhpt+.ssWFVlsVH.IlohIFhlhAhLNaPhGE.ppND.ChsLRFSpuMEhVRI..TLhhNhhAlhlNhsIhpFVK+a-	.................h...................................s.ThTshpaRDRIhhEahlpssshlhshhLsIF.lhh+.plhhphK..............sTIhFVTlGoFlLslPLhlhQsahVhhL.ss+pPpY.o.lhlCohlKshsSuTT.SstQVLPhs................VulYRYhlVVhct+hs.saFVlsVHsllohlFhlhAhLNaPhG-.ppNDhChhLRFSpuMEhVRI......TLhhN...hhAlllNh..sIhpFVK+a-......................................................................	0	9	10	20
+6510	PF06682	DUF1183		Protein of unknown function (DUF1183)	Moxon SJ	anon	Pfam-B_22014 (release 10.0)	Family	This family consists of several eukaryotic proteins of around 360 residues in length. The function of this family is unknown.	30.80	30.50	40.90	36.50	29.70	30.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.27	0.70	-4.82	14	202	2009-01-15 18:05:59	2003-07-28 13:50:05	7	6	157	0	140	197	2	268.30	35	85.91	CHANGED	h.hLlaLLlh.......stssps..hsspc.....tlLLpcVpsLTLhtsRhTouRRsuPlPQLKClGGSu.tCptapPcV..lQCtNpG..aDG.DVQWpCcA.sLspsa+hGps-VsCEGYcts-DtYlL+GSCGlEYpLpLTEtGccKhspth.pph.sthps.........................ps.ppt.t.....sshlhhlhhlhllAahlYthhhps.t.pttshsspsGhss...................tsss.tsts..uPPPPh.p........sshsss.s.sstssss.u...........tstts......tPGFW..TGhusGu..hhGYLhGppps..........pphstshss...........ta....ss.t..sptoupussusssou...T+ouSGaGuT+RR	.......................h........................t...........ts.....tlLLpcVpsLTLp.t.s.+hTouRRssslPQLpCl........Gs..ot.hC...s..h...apP.cV..hpCpNpG...............aDs...DVQWpCpA......s......Ls...tpa+h..G..p.ssVsCEGYcts-DsYlL+GSCGlEYp.......LthTchGt.p+htp.h.t.t.th........................................................stt.............hshlhhl.hhlhslsahl...Yphhhts..t.t..........s.ttsshst.......................................hhtt..s..s..s..sPP..PPh............................t.ss.......st.............................tt.ts......tPGFW..oGhusGu....hhGYhhGpppt.................................t...s..s...............h...........st.....................s..s......s.t..ustsss.....p+puoGaGuTpRR......................................................................	0	55	76	110
+6511	PF06683	DUF1184		Protein of unknown function (DUF1184)	Vella Briffa B	anon	Pfam-B_16725 (release 10.0)	Family	This family contains a number of hypothetical proteins of unknown function from Arabidopsis thaliana.	25.00	25.00	26.90	39.90	22.70	23.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.26	0.71	-4.67	4	36	2009-01-15 18:05:59	2003-07-28 14:53:55	6	2	2	0	29	36	0	122.20	37	85.12	CHANGED	R..pNK+.LppSRYSPY.....luThcp........EpQKEEAIRLGVELSLFVAEAMFLLSDsL.................................aVhETYIKPKNGVY..................FshGlt.LspIV.IL.....pssplVKspsFc+hNQELKKLEE+LRSsK-sSEANGFsREtI+SsILpLWKSLFEso..hh.s.KshsLEhF	................................................................................pp.K-EslpLGV-LSlalAEuMhlLsDsl.........................................................................................................h.thhpp..hppl-pplts.p.h.......R-.hc.ph..hWcp.h..................................................	0	9	9	9
+6512	PF06684	AA_synth	DUF1185;	Amino acid synthesis	Moxon SJ, Eberhardt R	anon	Pfam-B_22398 (release 10.0)	Family	This family of proteins is structurally similar to proteins with the Bacillus chorismate mutase-like (BCM-like) fold. This structure, combined with its genomic context, suggest that it has a role in amino acid synthesis [1].	20.00	20.00	24.00	35.60	19.80	17.10	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.00	0.71	-4.91	55	331	2009-01-15 18:05:59	2003-07-28 15:01:51	6	3	227	4	131	326	890	173.60	46	89.66	CHANGED	IRKhlshlE-hht.EGGtss......spPl+psussAVlc.NPaAGR.aVEDLpP.lhchut.LGthLspcllssLGs.scplEuYGKuAlVGssGElEHu.ALhHs.hhGtshR-sl...............................ssupullPuop+hGusGstlslPltHpssualRSHFsohchslsDAPpsDElllsLuhosGGRsHs......RlG	......................IRKhlshlE-ohh.EGG.+ss......spP.l.+hsussAVl+.NPaAG+...aVEDLpP.lhshus.LGphLsccllsslGs.uctlEuYGKAAlVGhsGElEHAuAllHs.+.....hGsthRcAl................................s...uKuhls.sspRGusGsslplPlhaKssthhRSHa.olphplsDAPtsDEIlVslususGGRsHsRlG..................	0	20	56	86
+6513	PF06685	DUF1186		Protein of unknown function (DUF1186)	Moxon SJ	anon	Pfam-B_22662 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 250 residues in length and is found in several Chlamydia and Anabaena species. The function of this family is unknown.	19.80	19.80	19.90	20.10	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.33	0.70	-5.21	7	84	2009-01-15 18:05:59	2003-07-28 15:06:29	6	3	79	0	27	61	0	224.90	33	79.09	CHANGED	M..ptll.ph.h.pthh.c.tlcthl.p+pthhP.Ll.hLcph.pph.pllsctsa.hHlYAhaLLAQFREppAaPLIl+hhShst-..lhhclsGDllTEDLuRILASVssGclphIppLIEspsls.YVRuAAIpuLlsLVuptplSREplIpYFtpLhpt+Lc+csSa..lWsSLVsssssLhPtELh.pIp+AapssLl-shFIshEDVEp.lshpp.-psLpcLhps..apLIpDslt-hEpWhp.....shEs	..................................hppllppLhh.pp.shlPc-AlctAl..pppplsP.LLplL-cAhcc...ss....-lhs-ssh.....psh...l.aAhaLLAQF.REoRAhPLll+Lh.uhpp-...h.cslhG.DslTEDLu+ILASVs-.-hshlpcL...I-ssplssYV+sAAluuLstLlshpplsR-pslpaatpLl...shtL.ccp..sh......shssLl.s....shssLhstELh..IpcsFp...tsLl..-...h.l.sh.........-cV.p.ht.p...-t.ht.h..t......lp.................s..................................................................................................	1	8	18	21
+6514	PF06686	SpoIIIAC		Stage III sporulation protein AC/AD protein family	Moxon SJ, TIGRFAMs, Coggill P, Bateman A	anon	Pfam-B_22771 (release 10.0), TIGRFAMs	Family	This family consists of several bacterial stage III sporulation protein AC (SpoIIIAC) and SpoIIIAD sequences. The exact function of this family is unknown.  SpoIIIAD is the an uncharacterised protein which is part of the spoIIIA operon that acts at sporulation stage III as part of a cascade of events leading to endospore formation. The operon is regulated by sigmaG [1].	21.00	21.00	21.20	21.50	19.00	20.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.60	0.72	-4.17	87	1045	2009-01-15 18:05:59	2003-07-28 15:12:29	6	3	398	0	251	634	10	57.50	29	83.45	CHANGED	hIhKIsGlullsthlstllKcus.sphAhhlslsutllllhhslshlsslhpslpplh	....hlhKIsGluhlsthhsplhK..csG.ppshAthlpLsGtllILhhslshlsslhcslpslh.......................	0	135	210	225
+6515	PF06687	SUR7		SUR7/PalI family	Moxon SJ, Coggill PC, Bateman A	anon	Pfam-B_22775 (release 10.0)	Family	This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homologue of human endophilin, suggesting a function for both in endocytosis [1,2]. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane.  Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localise with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation [2]. This family also includes PalI which is part of a pH signal transduction cascade.  Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH [4].	24.10	24.10	24.10	24.30	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.57	0.70	-4.77	99	777	2012-10-03 00:20:40	2003-07-28 15:22:48	7	5	142	0	570	851	0	230.30	18	62.52	CHANGED	hthlshll...hhsuhlhhlhssluss..t.........lpphahhph.sstth...................................................................................................................................t........................hpauhaGaCts.......................................t.pstpCop.spsuashssh..p.ht.p......................................thslPsshps......t......h...hphhhhhhlluhh...hohlshlh.hl.h...........................................uhhtt............................................................hhshlshlhshluh..lhshlusslssshalh..hht.hpp...........husphhshsWhslussllshlh	.......................................................................................................................................................h..hhshhhhhsuhlhhl.....l.shluss......s.......lpshhhhph..shtt.h................................................................................................................................................................................................................................................................................................................................................................................................................................t.h..ph..................hphulauaCts.........................................t.tt.ss.C.....op..spss.a.s.hssh......p.http.......................................thsl...P.s..shps............p...h..h.....hph.....hh........shhhluhh....hshl...shlh.sh..h................................shhhp........................................................................hhsh...h...s..........hlhshluh.lhshlushls....ss.h.as.h...httthppt...............htsphGsp..h..h.sh..hWhuh...shsllshh.h.....................................	0	135	305	487
+6516	PF06688	DUF1187		Protein of unknown function (DUF1187)	Moxon SJ	anon	Pfam-B_22781 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of around 62 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi. The function of this family is unknown.	20.70	20.70	22.20	40.90	19.00	18.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.16	0.72	-3.85	2	125	2009-09-11 12:17:23	2003-07-28 15:25:53	6	1	113	0	2	55	0	58.80	68	86.50	CHANGED	YpIsATIcK.GGsPspWT+YSc..hTtpECcK.hStcKEAGhshp.cV+l.sF.Cccl.sp	.YKITATIEKEGGTPTNWTRYSKSKLTKSECEKMLSGKKEAGVS.REQK.VKLINFNCEKL.SS.............	0	1	1	1
+6517	PF06689	zf-C4_ClpX		ClpX C4-type zinc finger	Bateman A	anon	Pfam-B_465 (release 10.0)	Domain	The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of proteins, and possesses a putative zinc finger motif of the C4 type. This presumed zinc binding domain is found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone. The molecular function of this domain is now known.	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.41	0.72	-4.44	130	4410	2009-01-15 18:05:59	2003-07-28 15:29:21	8	8	4219	9	955	2727	1965	40.10	59	9.68	CHANGED	phpCSFCGKspscVc+LI.AGs.s...saICcEClclspcIlpc-	.........h.lhCSFCGKoQc...-...V...+KL......I.....A..G.P.u.........VaIC....DECl-LCs-IIcEE.......	0	326	634	816
+6518	PF06690	DUF1188		Protein of unknown function (DUF1188)	Moxon SJ	anon	Pfam-B_22902 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of around 260 residues in length which seem to be specific to Methanobacterium, Methanococcus and Methanopyrus species. The function of this family is unknown.	26.60	26.60	27.20	60.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.64	0.70	-5.24	8	32	2009-01-15 18:05:59	2003-07-28 15:31:43	6	2	30	0	21	29	2	244.00	40	96.65	CHANGED	hchGITEoVKTlpS+l+ltDIlp-IucKKAsAIptaLEsEcFc..pAlIFGuYLoGualApsLsKcs.EVhlVDIpPaL+cll..spsI+Fh.......chhsshss.s.DLlVDLTGLGGlsP-hLS+LsPcVLIVEDPpGsh.DtsIpphsNTpERLs...pusK+GlL+TactuhsoKTSGTMTLoV-slp-uss-lpElDGVLYAlPsL+aaEtlLF+.E+DhcpFLsclspPAlTVSSLc-...h-sDElLpcNluhIpShVcE	................chGITEpVKThcSch+lhDIlpcIscKKupAlp.aL-utchc.......psllhGuYLoGsalAptLpc.t.pcVhllDIpPal+pll..spsl..cFh.........chhps..ph..s.DLllDhTGlGGl..ss-hLuchs.scVhIVEDPpush.DptIhchsNT.cRls....sutc+GlL+Ta..uhhSKTSGTMTLTl-slhcusp-lpcl-GVLYulssLcaaEtllF+.E+DhcKFlsplstPAlTlSolsc......-s-cllppNlscIpShl.......................................	0	6	11	17
+6519	PF06691	DUF1189		Protein of unknown function (DUF1189)	Moxon SJ	anon	Pfam-B_22923 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.	20.70	20.70	20.80	21.00	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.49	0.70	-5.06	12	358	2009-01-15 18:05:59	2003-07-28 15:44:05	6	2	333	0	41	223	1	238.10	27	93.78	CHANGED	MNlFpphhKSlYSP+DIAthRFQuIGKoIlYlhLLollsslPssYahsoslppuhsshppslpcDlPsFpIpsGcL....ps-tppsIphppsshsIlFDsosohpscp....ltsppsululLK-chll.sssGpsQphsYshhss.slsKcDlhshlsphculh..llslhslllalhssAhpFIpVolLAhIGhllpshtp+pLsY+plWploAYSlTLsTVFFsIMcsLphsVPsshhlsahVshIlLaLslKElP	...............................phhp.hhh.uh.a.sspchtph+..ht.thhKsIlYlhlLshlhslP........hshhhh....sslp........pslphspptIsc......clP.D.FpIc.NGpL.......p.s.c.tp.ps..h..h..p.ps...........sh....l...hs....FD.P.s..up.hsppp............l...s....pt.p....u....l...hhL...p.Dchll...hs..........s.......G.....t.o...p.o........h.........sYs.........p...hh...h...........slsp...psl.p....s...hl.s..t..h.....csh.....h........h.hlh.l.hh.llla...lh.plhhhF...l....s....l..h.l...lA.h.l..G...t.h.....h.u.th........p..p....pl.sa..tp..shplssYuhTlPslhhhIhph......h..p.....hh..hssuhhlh..hhlshlhha.lsh+p......................................................	1	16	31	35
+6520	PF06692	MNSV_P7B		Melon necrotic spot virus P7B protein	Moxon SJ	anon	Pfam-B_22334 (release 10.0)	Family	This family consists of several Melon necrotic spot virus (MNSV) P7B proteins. The function of this family is unknown.	20.80	20.80	22.60	22.10	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-8.99	0.72	-4.19	2	21	2009-01-15 18:05:59	2003-07-28 15:45:34	6	2	3	0	0	21	0	60.50	83	73.55	CHANGED	MACY+CDSSPGDYSGALLILFISFVhFhITSLSPQGNTYVHHFDNSSlKTQYVGISTNGDG	.........MAChRCDSSPGDYSGALLILFISFVFFYITSLSPQGNTYVHHFDNSSVKTQYVGISTNGDG...	0	0	0	0
+6521	PF06693	DUF1190		Protein of unknown function (DUF1190)	Moxon SJ	anon	Pfam-B_22972 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 212 residues in length and is known as YjfM in Escherichia coli. The function of this family is unknown.	21.80	21.80	22.40	22.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.35	0.71	-4.19	26	1138	2009-01-15 18:05:59	2003-07-28 16:26:18	6	2	707	0	103	463	18	162.00	45	76.05	CHANGED	cscps...sslapsss-Chpsssshst.....pCpsAYppAhscttcsAP+YsoptsCcu-FGtspCst.......................spsppu...............Gt..ahPhMuGahhuph...hsssst.h....ssQPlapots.....t....s.tspahsusGpshssuhpss...pshssscs........shtspssso+sl..SRGGFG..posuupouhGu	................................sDtssohYpsssDC.ssssst.us...........................CssuaNNAhpEt.psAPKasTp-sC.ucFG.tpC...............................................pspppS...................WhPlhuG.ahhuRl.............hts..s.t..........spQslasSts.su............suhshapssoGc..hstutsG.........+p...h.sscT........................uhus..tss.....T..s.....oTV....oRGGFG.cSsutpupht.............................................................	0	15	40	66
+6522	PF06694	Plant_NMP1		Plant nuclear matrix protein 1 (NMP1)	Moxon SJ	anon	Pfam-B_22388 (release 10.0)	Family	This family consists of several plant specific nuclear matrix protein 1 (NMP1) sequences. Nuclear Matrix Protein 1 is a ubiquitously expressed 36 kDa protein, which has no homologues in animals and fungi, but is highly conserved among flowering and non-flowering plants. NMP1 is located both in the cytoplasm and nucleus and that the nuclear fraction is associated with the nuclear matrix. NMP1 is a candidate for a plant-specific structural protein with a function both in the nucleus and cytoplasm [1]. 	25.00	25.00	25.50	25.50	20.90	24.80	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-11.89	0.70	-5.50	2	45	2009-01-15 18:05:59	2003-07-28 16:31:52	6	4	27	0	22	47	0	238.30	52	89.86	CHANGED	MAuKQMEEIQ+KLuhLpYPRANAPAQSLLFAGhERYtLLEWLFF+LLGD+SPFoQQNhQGDulDRDEEssRIQaLAEIApFLGITsosDsEAIQGRGSYE-RhEhL+LIVDLVEAShYADNPEWSVDcQltKDlQLlDuIAEKQuQIFSEECKLFPADVQIQSIYPLPDIu-LEhpLS-.op+h.sLQpMVp-LASKasYNPsE-Ys-sEhKLRtaLpSFL-Ts+oFNTIYTKEI+PWTHMMEVPQLHGFGPAANRLLEAYphLhKFLGNL+sLRDSasAhAAGS..osusEPSSVT+IIS-CEoALThLN+sLuILSsSlAREp	...........................................M-.lppKL..LtYsRupssuQpLLaA.GhERYtLL-WLFF+LLGD+SP.FoQQshQG-.uh.RDEEssRlQhL..hcIAph............LGlssphD.-sIpGcsoacpphthlp.I......l-lV...-ushhu-N...EaS..........lD-QhtKDlpLlDuIu..E+Qu...lFS-..ECKLFPsD.V..Q.I.............Q.....S..h..slPDls-LE.phuc.s+h.......h.....sLQphVp-LAuKas.Y.NP.sE-as.EsE.p.L+tpLpoFL-os+sFNhIYoKEI+PWTHhMElPQLHGhGPAANRLLEuYphLLKFLuNL+sLRDSasAhuhGS...........s......ustPSSVo+IlS-CEsALThLNcsLuILSsSlAR-.....................................	0	6	17	20
+6523	PF06695	Sm_multidrug_ex	sm_multidrug_ex; 	Putative small multi-drug export protein	Vella Briffa B	anon	Pfam-B_16747 (release 10.0)	Family	This family contains a small number of putative small multi-drug export proteins.	26.10	26.10	26.20	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.52	0.71	-3.95	36	377	2009-01-15 18:05:59	2003-07-28 16:38:41	6	1	337	0	147	343	71	120.40	33	70.77	CHANGED	ELRGAIPhul.shGls.hpuhllullGN.lLPl..PhlLhhlchlhpahpc.hthhpt....lhshlhc+scc.pspplc+a...u..alGLhlFVAIPLPGTGsWTGuLsAhlLslch+cuhhAlhlGlllAull	....................ELRGAlPhul..sh....G.....ls....h.tuhllu...l.lGN...hlPl.............Phlhhhhcplh..pa........htc....p..h..htt..........hhs.h...hhc+u...cc...tsppl..c+h...u....ahGLhLFVuIPL.PGTGAWTGsLhAslLshch+puhhAlhlGlllAulI........................................................	0	64	112	132
+6524	PF06696	Strep_SA_rep		Streptococcal surface antigen repeat	Moxon SJ	anon	Pfam-B_22674 (release 10.0)	Repeat	This family consists of a number of ~25 residue long repeats found commonly in Streptococcal surface antigens although one copy is present in the HPSR2-heavy chain potential motor protein of Giardia lamblia (Swiss:Q24984). This family is often found in conjunction with Pfam:PF00746.	21.70	21.70	21.70	21.70	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.60	0.72	-6.88	0.72	-4.10	32	550	2009-01-15 18:05:59	2003-07-28 16:42:00	6	17	71	12	39	523	0	24.90	51	8.42	CHANGED	AsYpAtLupYps-LAplQKsNu-tc	..AsYpApLupYps-LA+VQKsNA-sc...	0	3	11	25
+6525	PF06697	DUF1191		Protein of unknown function (DUF1191)	Vella Briffa B	anon	Pfam-B_16754 (release 10.0)	Family	This family contains hypothetical plant proteins of unknown function.	26.40	26.40	26.40	35.50	25.90	26.30	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.99	0.70	-5.59	11	98	2009-01-15 18:05:59	2003-07-28 16:46:46	7	4	18	0	70	84	0	258.40	34	85.36	CHANGED	po..pttslpsuphLDshlpDauh...Ruhp.+h+TGllYpl.sLPuNL..SGIchussRlRuGSLRRpGs.cas...-FslPsGlsVpPhscRlllVhpNLG.NaSs.lY...Ysls.G..YcllSPVLGLLsYsAsspusssp......pls.lhus.tsPIplsF..s.hsssstss.......usshCssFs.sG...sss.hss..ss.sCtsp.c.pG...HaulVl.ssps.tss..st..................ttp.ttW+.....hhsuhssGshlLGlL..llstls+hK+...+p+hc-MERcA.psE..sLc.suhVG+oRA.PsAssoRTpP	.....................t.......tsscsLDthlp-hAh......+uh.....p..+TGhlass...plP.uNL......oGl..clu..slRlRuGSLhppGs...pat....pFtlPstlhs.......pPhs.c.RlslVapsLG...NaSs.hY...Y.sls..G..YphluPVlGLhsYsusshssss.......pls.lhus..tsPIhlpF..sshpssst..s........ssspClsFshsG......psp...hp..shsssssChsp.p.pG..HaulVV.psps..ss.sss..........................................ptp.phWh.....hls....u....h....ssGhh.h...LslL...s..hl.lh.hhs..+h++.cp+hppMERpA.psEsLp.hshVGco+A.PsAssTRTpP..........	0	8	45	56
+6526	PF06698	DUF1192		Protein of unknown function (DUF1192)	Moxon SJ	anon	Pfam-B_22780 (release 10.0)	Family	This family consists of several short, hypothetical, bacterial proteins of around 60 residues in length. The function of this family is unknown.	24.30	24.30	24.40	24.40	23.80	24.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.86	0.72	-4.16	27	170	2009-01-15 18:05:59	2003-07-28 16:48:47	6	1	169	0	63	127	143	58.50	47	83.82	CHANGED	DD.-hP+p+ss...p.lupD.LohLSV-ELppRIuhLpuEIsRlcsthspKpAs+sAA-ulF+	...................D-.Dhs+.+su.......t.lupD.LulLSVsELcpRIALLpuEItRLcA-ht+KssoRuAAEALF+....	0	17	37	47
+6527	PF06699	PIG-F		GPI biosynthesis protein family Pig-F	Wood V, Studholme DJ, Finn RD	anon	Pfam-B_8602 (release 8.0)	Family	PIG-F is involved in glycosylphosphatidylinositol (GPI) anchor  biosynthesis [1-3].	21.70	21.70	21.80	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.67	0.71	-4.36	25	274	2009-01-15 18:05:59	2003-07-28 17:00:18	6	13	240	0	190	266	2	180.90	27	70.52	CHANGED	sallshhhlhlhhh..hhhh.hht...sshssLth.slhshslhpllYhhlp...hsssspp...............spp.................pshhhtlhull...lslllosPhhhhlllLaGAPl.lpplhcTaLhulHhShLshhPlhslhusshps..WpclFshpt.hs...hht.....sslssllGuWlGulPIPLDWDRPWQpWPIollsGAalGhhlGh.hlushh	...................................................................................................................h.........h.h.......h....ht....s.h.hhh....h..hhh..hha.hhlp....sststt.......................................................................................thh.thhphh...lhhlhus.hhthlhlLaGAPl..h.ph..hhc....Thlh.....uhhhohLsh..h.Ph.....hh.....lhGs...........s.hps..................Whpl.h....sh..t...t.shs...............hht................sslusllGA.WlGAhPIPLDWDRsWQtWPlshshGuhhGhhlGhhlu...h.............................	0	53	97	153
+6529	PF06701	MIB_HERC2		Mib_herc2	Artzt K, Studholme DJ	anon	Pfam-B_6026 (release 8.0)	Domain	Named "mib/herc2 domain" in [1]. Usually the protein also contains an E3 ligase domain (either Ring or Hect). 	19.40	19.40	19.50	19.80	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.46	0.72	-4.01	9	640	2009-01-15 18:05:59	2003-07-28 18:16:04	8	155	98	2	410	595	5	64.20	47	5.03	CHANGED	GsRVVRGsDW+Ws-QDGs.uthGpVhp.......tupcuhlsVpWDsGspNsYRhGhcGpaDL+ls-ss	.....GsRVVRGsDW.....c..W..sc.QDGGpG...p......hGpVsp.......................................t..s..sc........uhlsVpW.D.sG.s.p.ss..YRhGhc.Gt..aDL+lhs.....................	1	148	173	300
+6530	PF06702	DUF1193		Protein of unknown function (DUF1193)	Vella Briffa B	anon	Pfam-B_16766 (release 10.0)	Family	This family represents the C-terminus of several hypothetical eukaryotic proteins of unknown function. Family members contain two conserved motifs: DRHHYE and QCC, as well as a number of conserved cysteine residues.	23.60	23.60	23.60	23.60	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.56	0.70	-4.93	19	305	2009-01-15 18:05:59	2003-07-29 09:31:20	7	7	92	0	209	297	0	201.40	42	44.38	CHANGED	Fhhssu..............sNhCFaGcC.YYCcs-aAlCG..ps-hlEGSlshaLPs..hhshppaRsPWpRoYpcscp.AcWEssssYCss.VKpp.PYDpGtRLLDlIDhulFD...................FLIu.........Nh.......DRHHYEoFpchsst.......shl.............................................laLDNu+uFG+ss+DEhSIL..APLhQC.ChlR+STh.RLpllp..s.ttLocshcEuhtpD....lsPlLscsHlpAl-RRLthlhpslcpChcppG..tpVl.pD	............................................................hosusNhCFaucC..YYCpppcslCG..ps..c..hEGSlshaLPs....hh.htphRpPWtRoYpc.tph.A....pWEh.....s...sYCpt...V+ph.P...Y..s..pu..RLLDlh...DhslFD...................F.LhG....................NhDRHHYE..sF..pt..s.st................shl...................................................................laLDNu+G.F...Gp.spD..EhSI.L...uP.....L.QC.C............h...........IR+STh.+LphLtt...s.....htLopl..hccuh.t.pD......lsP...l...L...s-....sHLpALDRRLthlLpsVcpChcp......G...ttVh...............................	0	51	67	138
+6531	PF06703	SPC25		Microsomal signal peptidase 25 kDa subunit (SPC25)	Moxon SJ	anon	Pfam-B_22374 (release 10.0)	Family	This family consists of several microsomal signal peptidase 25 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 25 kDa subunit (SPC25).	22.80	22.80	23.30	23.40	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.98	0.71	-4.66	32	365	2009-09-10 23:37:10	2003-07-29 10:05:20	6	7	290	0	231	339	3	149.90	27	76.60	CHANGED	slKpshD-ulsshltph....G..........appsapLhDs+LhlGhsulslAshuhhhDh..hhsa.po+.shhhhsVshYhlLsslLhhashhhEKshlahuppct.....sscplpls...........ophpK.....asPhYpl..plshpcspstt.....p..hphpts.hscaFstsGhhhtshapphlsp.lssl	..............................tlKpslDDulpphLhpt.....t.....................atEsatLhDsRLhlshhushlAhhuhhaDh..hhsFspo+....shlhhsVh............s...........Y...Fl...h.ulLslasha.h..E.Kshhhhuhpct.............ssct.....hplu.............Sphc.+.............asshYpL..plshtsspstt..........pp..hphsps.hspa...........FcpsGhlh.shapp.lsphhp..h.......................................	0	84	131	191
+6533	PF06705	SF-assemblin		SF-assemblin/beta giardin	Moxon SJ	anon	Pfam-B_22934 (release 10.0)	Family	This family consists of several eukaryotic SF-assemblin and related beta giardin proteins. During mitosis the SF-assemblin-based cytoskeleton is reorganised; it divides in prophase and is reduced to two dot-like structures at each spindle pole in metaphase. During anaphase, the two dots present at each pole are connected again. In telophase there is an asymmetrical outgrowth of new fibres. It has been suggested that SF-assemblin is involved in re-establishing the microtubular root system characteristic of interphase cells after mitosis [1]. 	30.00	30.00	30.30	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.61	0.70	-5.23	6	409	2009-01-15 18:05:59	2003-07-29 10:19:12	6	3	47	0	84	409	2	191.20	61	89.87	CHANGED	ssousKLEHVsE+Fuuhas-lEpEKQsRRlsEuoRhpllpEuls+LEKulEAElKRRAESDKQlQsHFEuEl+sLpERptpQlsDhpsulKsAl-uLup+lpDLHoll+-ER-pRRsDIEHLAsSLVsKVNECVuAlDEERspRhpcpshhhK+luEDlhplpp+lDTEKssR-u-lSuLRoE.lH-sluNRNlsDEQFcshVLDElsulKuALshEREERlAEDDEIVQAlNDYT+ALQ-GL+lVss	.........................................................................hcsR...RVDDDTRVKMIKDAIAHLD....RLIQTESRKRQuSFEDIRE...EVKKSADNMY.LTIKEEIDT.MAANFR.KSLAE.......MGDTLNNVETNLQNQIAI..HNDAI...AALRKEALK.SLNDLETGIATENAERKKMYDQLNEKVAEGFARISAAIE...KETIARERAVSAAT..TE.Ls.ssh.............................................................................................	0	59	69	80
+6534	PF06706	CTV_P6		Citrus tristeza virus 6-kDa protein	Moxon SJ	anon	Pfam-B_22973 (release 10.0)	Family	This family consists of several Citrus tristeza virus (CTV) 6-kDa, 51 residue long hydrophobic (P6) proteins. The function of this family is unknown.	25.00	25.00	30.10	30.00	20.00	18.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.69	0.72	-4.48	2	15	2009-09-14 12:01:29	2003-07-29 10:22:59	6	1	2	\N	0	16	0	50.70	86	98.70	CHANGED	MDCVIQGFLTFLVGIAVFsAFAtLIIIVITIYRCThKPVRsASPYGTHATl	MDCVIQGFLTFLVGIAVF..SAFAGLIIIVITIYRCTTKPVRNsSPYGTHATV.................	0	0	0	0
+6535	PF06707	DUF1194		Protein of unknown function (DUF1194)	Moxon SJ	anon	Pfam-B_22986 (release 10.0)	Family	This family consists of several hypothetical Rhizobiales specific proteins of around 270 residues in length. The function of this family is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.22	0.70	-5.35	35	226	2012-10-10 16:07:06	2003-07-29 10:26:08	6	6	125	0	81	566	155	199.90	36	75.78	CHANGED	ss.DltLlLAVDVStSlDtpEhplQR-GaAsALssP-VhpAlhu.GshGclAlshhEWuGsspQplllsWolIcsspsApshAspltssPpttspt.TuIusAlsa.usshhspsshtuhRRVIDlSGDGssN....pG.sPs..tAR-tshstGl.sINGLsIhssss.s..........sLssYYpssVIuGPGAFVlsspsac-FscAlRRKLlhEluuhs	...........................................................................................s.DltLlLAlDVStSlDt...sEh..pl..Q..pcGh.A...t.A.L.p.s..sp.lh.pA.l.hs...u....G.plAlshhEWuu.spQ........plllsWphIss...tsupshAspl..tst.......s.....p.t.....tsph..TulusAlth.us.s.l.h..s.....ps.s....h.......uhR..+....VIDlSGDG..sN..........pG...sPs......tuRctsh..s.....p.G..l...sIN..GL...sIhspss...........................sLs.t.YYpspVIuGP......G.....AFVhsspshp.-FscAlRcKLlhElus.s..................................................	1	15	38	51
+6536	PF06708	DUF1195		Protein of unknown function (DUF1195)	Moxon SJ	anon	Pfam-B_22828 (release 10.0)	Family	This family consists of several plant specific hypothetical proteins of around 160 residues in length. The function of this family is unknown.	25.00	25.00	78.30	78.00	21.70	22.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.11	0.71	-4.80	7	56	2009-01-15 18:05:59	2003-07-29 10:29:54	6	2	19	0	25	53	0	141.80	53	85.58	CHANGED	M+tsct...hPsoTsosssp....hsupppsuttu..hhG+GRYKhWALAAIhLLAhWSMhTGoVoLRWSuGsl...sphs-DlshPhhDDLDVLEMEEREKlV++MWDVYTpot..pl+LPRFWQEAFEAAYEELsSDsssVp-AAlSEIA+MS.lRplpl-sss.cSs	.................................s..............thts....utsu..lhGKGRYKhWALAAIhLLAhWSMhsuoVoLRWS.u..GsL...sphssDlssPlh.DDLDsLEMEEREKlV++MWDVYTpop...clRLPRFWQEAFEAAYEELsuDs.ssVR-AAlSEIA+MS.l+plpl-.ss.p..p.................	0	3	14	20
+6537	PF06709	DUF1196		Protein of unknown function (DUF1196)	Moxon SJ	anon	Pfam-B_23162 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 51 residues in length which seem to be specific to Vibrio cholerae. The function of this family is unknown.	21.70	21.70	24.90	24.70	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.76	0.72	-4.03	2	41	2009-01-15 18:05:59	2003-07-29 13:17:12	6	1	18	0	4	14	0	48.50	92	96.46	CHANGED	MTVPLEAFVMCVFLMPTLPFKGVAKGIYAKQHSIKsaHIHKTKMLHlDIFR	MTVPLEAFVMCVFLMPTLPFKGVA.KGIYAKQHSIKsHHIHKTKMLHIDIFR.	0	4	4	4
+6539	PF06711	DUF1198		Protein of unknown function (DUF1198)	Moxon SJ	anon	Pfam-B_23016 (release 10.0)	Family	This family consists of several bacterial proteins of around 150 residues in length which are specific to Escherichia coli, Salmonella species and Yersinia pestis. The function of this family is unknown.	25.00	25.00	42.00	41.80	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.85	0.71	-4.39	5	511	2009-01-15 18:05:59	2003-07-29 14:21:16	6	1	506	0	25	130	1	147.00	77	97.65	CHANGED	MlWIILATLlVVFIVGFRVLTSDTRRAI+RLSERLsIcPVPIESMIDQMGKTAGsEFIRYLcRPsEuHLQNAAQVLLIWQssIVDuSDcNlphW+RLLpKARLAAPLT-sQlRLALGFhRELDPDAaELssFQpRYNphFpPE-GVaW	...MIWIMLATLAVVFVVGFRVLTSGuRKAIRRLS-RLNIDVVPVESMlDQMGKoAGcEFLRYLHRPDESHLQNAAQVLLIWQlVIVDGSEQNLhpWHRlLQKARLAAPITDAQVRLALGFLREhEP-MQ-INAFQhRYNAFFQPtEGVHW.................	1	1	5	14
+6540	PF06712	DUF1199		Protein of unknown function (DUF1199)	Moxon SJ	anon	Pfam-B_23160 (release 10.0)	Family	This family consists of several hypothetical Feline immunodeficiency virus (FIV) proteins. Members of this family are typically around 67 residues long and are often annotated as ORF3 proteins. The function of this family is unknown.	25.00	25.00	111.00	110.70	21.60	18.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.53	0.72	-4.15	5	6	2009-01-15 18:05:59	2003-07-29 14:25:47	6	1	2	0	0	4	0	51.80	73	79.54	CHANGED	MLaRNScsVPAuIYRSNNIFsNNQuSGSMETSTISSPSRRIRNNFLGLLGTR	ML.RNuchVPs.IYRsNNIFssNQsSGSMETSTISSPSRRIRNNFLGLLGTR	0	0	0	0
+6541	PF06713	bPH_4	DUF1200;	Bacterial PH domain	Moxon SJ, Bateman A	anon	Pfam-B_23245 (release 10.0)	Domain	This family consists of several hypothetical proteins specific to Oceanobacillus and Bacillus species. Members of this family are typically around 130 residues in length. The function of this family is unknown. Members of this family have a PH domain like structure [1].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.36	0.72	-4.11	46	441	2012-10-04 00:02:25	2003-07-29 14:29:16	6	2	256	0	64	351	8	72.70	29	53.89	CHANGED	TpYpl..psspLhlpsG.hh+pc.IslpcIppIp.sps.hs....usAhohcplpIpYs..........thsp.lhISPcccccFlptLpcps	.............+Ypl..psssLhl+tG.hh+pc...Islc-I+pI..cpstp.h........u.ths.hcpLEIp.Ys..........tacs.hhl..PpccccFlshlccps............................................	0	24	53	57
+6542	PF06714	Gp5_OB		Gp5 N-terminal OB domain	Bateman A, Mesyanzhinov VV	anon	[1]	Domain	This domain is found at the N terminus of the Gp5 baseplate protein of bacteriophage T4.  This domain binds to the Gp27 protein [1].  This domain has the common OB fold [1].	25.00	25.00	27.10	25.80	24.70	23.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.17	8	60	2009-09-11 05:11:09	2003-07-29 14:46:33	6	7	59	3	0	62	590	132.00	37	21.49	CHANGED	GlHPsQKs+u-shGlsTE-LLWMoshpslTSAAlSGIGpSPTGlVEGTaVaGaFLDKapQsGllLGTYsGIYp-KPssscGFsDPsGpYP...RYlGNDVNlLARGGhp.clu.sp..soshI...........QDtNoslAlsPD-pPhsEI.sDssPc	........G.Hs..+.ps-spGlPTEcLPWholl.PsooAuhS.G.lGtSsTGll.pGotVhGaaLD.ch.pps.slllGoh...sGhhpppssppcGFsDPsGpYP...hhlGsDsshLstGs.....phh.st..ps..h...........pstNhshuh.sst.s.st...sspP..........................................................................	0	0	0	0
+6543	PF06715	Gp5_C		Gp5 C-terminal repeat (3 copies)	Bateman A, Mesyanzhinov VV	anon	[1]	Repeat	This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5.  This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerise to form a beta solenoid type structure [1]. This family also includes repeats from bacterial Vgr proteins.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.33	0.74	-7.26	0.74	-3.66	89	445	2009-01-15 18:05:59	2003-07-29 16:39:43	7	22	205	27	84	435	64	24.00	35	5.73	CHANGED	usto.hsVtuNpohsVsu.spopsls	.......tspopsVtsNRTpsVss.NcT.ols..........	0	16	36	60
+6544	PF06716	DUF1201		Protein of unknown function (DUF1201)	Moxon SJ	anon	Pfam-B_23269 (release 10.0)	Family	This family consists of several Sugar beet yellow virus (SBYV) putative membrane-binding proteins of around 54 residues in length. The function of this family is unknown.	20.90	20.90	22.30	22.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.85	0.72	-4.15	2	5	2009-01-15 18:05:59	2003-07-29 16:55:40	6	1	3	0	0	5	0	51.60	68	96.63	CHANGED	MDCVLRSYLLLAFGFhICLFLFCLVVFIWFVYKQILFRsTs.SNEARaN+STVV	MDCVLRSYLLLAFGFLICLFLFCLVVFIWFVYKQILFRNTPPSNEARFNRSTVV.........	2	0	0	0
+6545	PF06717	DUF1202		Protein of unknown function (DUF1202)	Moxon SJ	anon	Pfam-B_23300 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 335 residues in length. Members of this family are found exclusively in Escherichia coli and Salmonella species and are often referred to as YggM proteins. The function of this family is unknown.	21.10	21.10	21.30	22.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.83	0.70	-5.15	4	434	2009-01-15 18:05:59	2003-07-29 16:59:04	6	1	410	0	5	129	3	303.60	78	92.48	CHANGED	hLhoG.shADspsPTENILK-QFpKQYHGILKLDuITLKNLDucGNQATWSAEGDlSSu-DLYThVGpLADY.llEpTWTKDKPVKFSAMLTSKGTPASGWoVsFYShQhAASD+GRslDDIKTNsKYLIVNS-DFNYRFuplcuuhssQKsSIsuLcc-lpALDKphlsApKtADAYWGKsAsGKphTRt-AFKKlpppRD-FNKpNDSpsFAhKY-KEVYQPAlsAC+KQSEcCYEls....IQQKRDhDIpEQRRQsFLKSpcLsRKlQsDWITLEKGQYPLshKVpclppppssIhMKIcDINpu...aK+	..........................................MLMTGNuWADGEPPTENILKDQFKKQYHGILKLDuITLKNLDAKGNQATWSAEGDVSSSDDLYTWVGQLADYELLEQTWTKDKPVKFSAMLTSKGTPASGWoVNFYSFQAAASDRGRVVDDIKTNN.KYLIVNSEDFNYRFSQLEoALNsQKNSIPALEK-VKALDKQMVAAQKAADAYWGKDANGK...QMTR..E-AFKKI.HQQRD-FNKQNDSEAFAVKYDKEVYQPAIAA.CHKQSEECYEVP........IQQKRDFDINEQRRQTFLQSQKLSRKLQDDWlTLEKGQYPLTMKVSEINSKKVAILMKIDDINQANERWK.K...............................................................	0	2	2	3
+6546	PF06718	DUF1203		Protein of unknown function (DUF1203)	Moxon SJ	anon	Pfam-B_23313 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 155 residues in length. Family members are present in Rhizobium, Agrobacterium and Streptomyces species.	20.60	20.60	21.40	21.00	20.50	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.45	0.71	-4.28	20	173	2009-01-15 18:05:59	2003-07-29 17:06:05	6	1	171	0	60	169	7	117.00	36	73.61	CHANGED	GhPCRpsL+cuctG-plLLLuYpPa........ssssPYsEsGPIFlptpsspttsu.-slP...........sl.sutshslRGYsu-s+Il..sucllsss-.......hsuthcclLscs-VAalHVRsAcpGCYtsRl-R	..GhPCRhsL+cupsG.Ep.llL.lsYp.h........ssssPYptsGPIFl+ttssssh....s..s....t....lP...........hl.psch...hslRuYsucshlV..sucVspuss.............lcptlc.clFs.ss..-V..sYlHl+sAc.GCatsclcR............	0	10	36	47
+6547	PF06719	AraC_N	AraC_N-term; 	AraC-type transcriptional regulator N-terminus	Vella Briffa B	anon	Pfam-B_16798 (release 10.0)	Family	This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains [1]. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating [2]. All family members contain the Pfam:PF00165 domain.	24.20	24.20	24.30	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.65	0.71	-4.92	170	1635	2012-10-10 13:59:34	2003-07-29 17:09:29	8	4	1088	0	429	1324	58	152.60	33	50.71	CHANGED	Ts..lsulplhR.sspsst.h.sslYcPulsllsQGpKpshlG.ccsapYcstcYLlsolslPhpsplhpASs-pPhLultlclDhshls-Llhchs.ts.tstsstt.................ulsssphsssLh-AhhRLlcLLcp.P.p-hslLuPhlhREIhYRLLpGspGstL	....................................lsslplhp.sp.ps.h.s.hs..ss.h.Y.cPul.sllhQGpK.hsh..l..u..c.c.s..a....p..YDsscYLlloVsLPhpscs...Aos..-tPhhulpLslDht.lt-Llhchspstt.hps.shst.................Glssuslsp..pllsAs.RLL.c..l.h..c..p.P..hD..t.p.l.Lus.IhREIlY+lLpGspGstL...........................	0	101	207	325
+6548	PF06720	Phi-29_GP16_7		Bacteriophage phi-29 early protein GP16.7	Moxon SJ	anon	Pfam-B_23362 (release 10.0)	Family	This family consists of several bacteriophage phi-29 early protein GP16.7 sequences of around 130 residues in length. The function of this family is unknown.	25.00	25.00	47.60	46.80	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.70	0.71	-4.48	2	6	2009-09-10 16:38:04	2003-07-29 17:11:43	6	1	5	10	0	7	0	129.30	60	99.11	CHANGED	MEAILMIGVlsLCVIFLLSGRNNKKhQEARELEDYLEDLNpRlsQRTQILSELNEVIoNRSlDKoVNhSACElAVLDLYEQSNIRIPSDIIEDhVNQRLQoEQ-VLNYIETQRTYWKLENQKKLYRGSLK	.......................MEAILMIGVlsLCVIFLLSGRNNKKKQEsRELEDY..LEDLNpRlsQRTQILSELNEVIoNRSlDKoVNhSACElAVLDLYEQSNIRIPSDIIEDlV.NQRLQoEQEVLNYIETQRTYWKLENQKKLYRGSLK..	0	0	0	0
+6549	PF06721	DUF1204		Protein of unknown function (DUF1204)	Vella Briffa B	anon	Pfam-B_16832 (release 10.0)	Family	This family represents the C-terminus of a number of Arabidopsis thaliana hypothetical proteins of unknown function. Family members contain a conserved DFD motif.	21.00	21.00	21.00	25.10	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.41	0.70	-5.11	2	9	2009-09-11 06:55:55	2003-07-29 17:14:31	6	2	2	0	4	16	0	169.10	40	38.05	CHANGED	c+.s.Lhc+.lcShShEAsphKsthtsLAhp+phhup...-hsRsp.Dhcc.+cKhsELtsRhhSEhKRLRpRR.cYAp..pppAL.+hAs.Fpu..........DhlthpPKFh-aNQVsGNlthL-tLVEuGElEhKSs-hM.RLlADt-tLcAEVcuFtIT-l.csDFDVhTLFtcl..-p+.....sus.s.TEuEc.t-spsEstuQtt.chsG.h.scsthAss.-	...................................................................................................................p.KhscLtsRhhuE.KRLRppR.chAc..p..pptL.+htp.hptchptl+hcl.DcphthpPKFh-h........NQVsGslthL-tLl-sGphEhKSs-hM.RLlADt-tLcAEVcuFtIT-l.csDFDVhTLFtcl..-p+.....sus.s.TcuEc.t-spsEstuQtt.chsG.h.scsthAss.-..................	1	4	4	4
+6550	PF06722	DUF1205		Protein of unknown function (DUF1205)	Vella Briffa B	anon	Pfam-B_16780 (release 10.0)	Family	This family represents a conserved region of unknown function within bacterial glycosyl transferases. Many family members contain Pfam:PF03033.	20.70	20.70	20.70	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.38	0.72	-3.75	33	513	2012-10-03 16:42:30	2003-07-29 17:22:06	7	8	340	18	67	391	0	95.10	41	24.87	CHANGED	lDssPsShch...s...su..hssl..shRYVPYNG...uVlPs..WLhps....ssRs.RVslTLGsottp.h.tsst.sslscllsulucL.DsElVsTlsspptttL.uslPsNVR	.................................IDssPPShpl........s..........su.....pPsl...sMRYV....PYN..Gu....AVh.s.Whccs.........scR.t.R.lhloLGTspsh...st.........Ghc.......................hluhlh-..u..su....-l.DAEl.llpls.ss.sps.sL..psLPsNVR.............	0	21	47	59
+6551	PF06723	MreB_Mbl		MreB/Mbl protein	Moxon SJ	anon	Pfam-B_471 (release 10.0)	Family	This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl [1].	56.40	56.40	56.40	56.40	56.30	56.30	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.76	0.70	-5.84	31	4314	2012-10-02 23:34:14	2003-07-30 09:48:34	8	4	3147	5	973	7141	4347	321.20	54	95.81	CHANGED	usDluIDLGTANTLV..YV+G+GIVLsEPSVVAlcps.....sppllAVGpEAKpMlG+TPusItAlRPh+DGVIADa-hsEpMLKaFIp+lps..ppth.hpP+lllClPoGlTsVE+RAlp-uuppAGA+cVhllEEPhAAAIGAGLPVpEPsGsMVlDIGGGTTElAVISLGGIVhSpSlRVAGDchDEuIlpYlR+pasLlIGEpTAEpIKhEIGoAh.spcsc...ph-l+GRDlloGLP+slplsupElp-ALp-slstIl-u.l+psLEpTPPELuuDIh-+GIlLTGGGALL+GLDchlpccTslPVhlA--PLsCVAhGoGcsL-phctlpp	.............................................................................................................s.pDluIDLG.TA.N..T..L..l....YV...+...G...+.........G...I........V.........L...........s.........E.............P.......SV..VA.lcpc............................sppl..h....AV..G.c......-.....A......K....p....M....l....G.....R....T................P..G....N....I................t.......A.......I......R.........P..............h...............K.............D.......G.......V..........I..............A........D..........F..............p.........l.......T........E.......p..........M....L..p..........a......F.I....c.p.lps..........pp...h.h......s......pP...Rl...llCVPsGsTpVE.+R.AlcE...uA..h..t..A..G..A..R..-.Va.LIEEP..h..AA..A....I..G...A.G....L.....P........V....p....E.....P....s....G....s.....M..VV...DIGGG.TT.EVA..V..I.....S.....L...........G...........G.............l....V.....h.....S.....p.....S.....l.....R......l....uGD......+.h......D....-....A....I.....l....s....Y....l.............R....+....p......Y.............s...........l.........L.......I......G...............E.............p.............T.............A.........E.......c...I........K...h..........c.....I...G.....o......A..h...s...s.....s....c..sc..............ph-...V.....R............G............R............s..........L............s............s............G.............l............P...........+...........s.......h...........s...........l....s....S........s....E.........l...........h....E.A....L.........p.E.sl..s.........t.........I....V.s.A....V.+.s.sLE..p...s......P.........P.....E.....L......A......u.....D.I..h.-.........+........G.........l........VL.TGG.GALL+......sLDclL....t-E.T.....u.......l.....P.V.h.l.A-..-.PLsCVAhGsGcuL-.h-h..pt.................................................................................................................................	0	366	693	848
+6552	PF06724	DUF1206		Domain of Unknown Function (DUF1206)	Yeats C	anon	Yeats C	Family	This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	22.30	22.30	23.20	22.90	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.23	0.72	-4.22	149	831	2009-01-15 18:05:59	2003-07-30 09:49:12	6	3	248	0	368	915	30	72.50	25	76.68	CHANGED	Rh......GhsupGllahhlGhhs........ltsAh..st......supssutsuultpLhsp.PaGthLLsllulGlluaulaphhcAhhcph	............RhGhsupGllahhluhhs..........lth...Aht...s.......supssstsuultpL....hsp.P.hGphLLhllulGlluhulaphhpAhhtt..........	0	107	231	321
+6553	PF06725	3D		3D domain	Bateman A	anon	Bateman A	Domain	This short presumed domain contains three conserved aspartate residues, hence the name 3D. It has been shown to be part of the catalytic double psi beta barrel domain of MltA [1].	23.80	23.80	24.00	24.20	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.45	0.72	-4.00	41	3329	2012-10-01 21:39:58	2003-07-30 11:02:56	6	38	2021	13	572	2394	113	70.00	40	19.85	CHANGED	polAVDsslIPlGohlalpu.................hthslAtDTGuAIKGs.+lDlahuosscAsp.hG..p+psplalLt	.................h.slAVD.plIP..lGohl..alps........................................ht..hhl.AtDTG.G..AI...K....Gs..+lDlah.Ghs...s........cAsp....h.G...++ps.c.ValL.............................	0	203	382	471
+6554	PF06726	BC10		Bladder cancer-related protein BC10	Wood V, Moxon SJ, Coggill PC	anon	Wood V	Family	This family consists of a series of short proteins of around 90 residues in length. The human protein Swiss:O60629 or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs) [1]. The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript.  All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues [2]. The function of this family is unknown.	19.60	19.60	20.20	19.80	18.60	17.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.15	0.72	-3.95	11	187	2009-01-15 18:05:59	2003-07-30 12:38:41	7	1	168	0	112	155	0	61.80	41	52.91	CHANGED	MaCL+ahlPlLllPh...s.uhhpAsshFhh.laLluhhlcppPCsaCullhhhhhhs.s..psshssh	.....MaCLp.hhL.PlL.lIPh...p..hh.upshFhh...hall.....uhhl.++PCshCullhLhhhhh.s....ssWus...........	2	23	43	82
+6555	PF06727	DUF1207		Protein of unknown function (DUF1207)	Moxon SJ	anon	Pfam-B_23454 (release 10.0)	Family	This family consists of a number of hypothetical bacterial proteins of around 410 residues in length which seem to be specific to Chlamydia species. The function of this family is unknown.	20.30	20.30	25.20	22.50	15.80	18.40	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.18	0.70	-5.63	8	77	2009-09-11 12:14:12	2003-07-30 13:56:56	6	1	75	0	30	57	13	311.30	36	83.55	CHANGED	+hlcssh.sll.csss..loLPsDplhups..spIsphlp-lPhlTuVEIsE...............pp..sshsptsstsss..cpps.sscs.sshtslWLPpGp.LFpPLlADPRtsp.SAuaR..ascplsGs...+lGuVuFG-slPhhR.sslu+apssh-lGLQuGVFSsFDLDsPSosLlNoDFhVuhhhShtsupaShRhRlYH.SSHLGDEFLLp+..sshsRhNLShEulDLhlSachtP..lRVYGGsGaIhp+-so.sl+PahhchGlELR.uPatl....s.LhucPlFAhch+saEppcashD.ShhhGhEau+FpshG...RKlphllEYapGaS.pGQFhREpscYhGhthpYtF	....................................................................................................................................................................p.t..sh...shhpslaLPp.ss.LFsPLlADPRpsp.SAuhR.....hs-ps.hGp................pluussFGuchhhhR..h-h..upaps..sh-lG....lQG.uVFSsFsL-p.....spu...........sh.VNo.DFhlus.hh.sas.........h....s...........ca...ShRhRlaHlSSHLGD........EF.....l.......Lsp..........Ps.h.p...R........h.N.hScEulDhhsShch........sPp....lRlYGGhGYll...s+...-.o.stcPhhhpuGlElR.....Pash.........ssLcupPlaAh.c...h+....haE-pcashD.o..hhsGhEau.....+hps.lG...RKlRshlEYapGaSpcGQFh+-pssYhGhtlpYsF.........	1	12	16	27
+6556	PF06728	PIG-U		GPI transamidase subunit PIG-U	Wood V, Moxon SJ	anon	Pfam-B_7677 (release 9.0)	Family	Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI [1]. 	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.54	0.70	-5.60	64	358	2012-10-03 03:08:05	2003-07-30 14:05:33	8	7	283	0	247	623	14	321.40	29	81.80	CHANGED	hsuhhlRlhl...hhsshs.phLss+lEl...................STPlsSa+plpE.GhaLhppu.l...........sPYsGul.hH..........psPLlLhlhshl..........................h.............hsllahlhDllsAhhLhth...........................................................thppstpph.tt..t........................hsshhlushYLhNPhslhoslutSTsshsNhhlhhslhsss.p.........sp...............hhhuslslAhuoa.lohYshhLlhPllhhhhp........................................................t.phh.hhhp...hhhlahsslhsLhh.hSah.lsu.......................sas...FlpssYshhlph...p-Ls...PNl..GLaWYFFsEhF-pF+sFFlhlFplhs.hhallP.LolRLpcp...........PhhhhhlhlulhulFK..sYPolu...............DsuhaLuLlslapp.l......................hthh+ash..lss.sshlhshlLuPlhaaLWIhtGoGNANF.FauloLla	.....................................................................................h..shhhRhhl....hhssh.....lstpsEh...................soPlsS..a+p.............l........E.GhhLhp.s...h...........sPYsGsh.hH.........................psPll.l.hhthl............................................................htllahhhDhlsAhhLhhh................................t............................................ptht.....t.........................................................shhluhhYLhNPhsl.h.oC.lu.tS.osshsshhlhhhlhtsh.p...............sp................................shh.uhhhl.uhuoa.hShYPhhLhsPhlhhhhp............................................................................................t.hh...h..hht............hhhhh.h.s.slh.........hlhh...hShh..hhs.......................sap......al.tsYGhhl.h......DLs......PNl...G...La....W...Y....F....F.h....E.....hF....-.p....F....p.........F..F.....lhl...Ft.lph....hha.hhP....Lsl...+h..+cp..................Ph.h.h..hhhhlulhulh...K..sYPolu.....................D...suh...a...huhlslatp...l.........................h..h.h.+..h.....hhh...hhhlh..s.hLhPhhaaLWIhtGouNuNF.aauhoLsa.........................................................................................................................................................	0	91	140	206
+6557	PF06729	CENP-R	NRIF3;	Kinetochore component, CENP-R	Moxon SJ	anon	Pfam-B_23665 (release 10.0)	Family	This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression [1]. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis [2,3].	27.00	27.00	32.30	32.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.65	0.71	-4.51	11	37	2012-10-08 12:26:51	2003-07-30 14:33:12	7	3	28	0	15	54	0	117.50	55	78.39	CHANGED	+K+slssYSPTTGTpQhSPaSSPTSsptQ-h+NGPSNGp...cp.sc.slscRtpspspD.DtFMsLhScV-pS.EcIhElhpNLoSlQALEGSRELENLIGlSpuSChLppEhQKT+cLMoKspK.cLhcKpputlPs+-h	....+KKslhsYSPTTGTpQhS.FuSPoSsccQcHRNG.SNtp..pcp.sc.sLocptpspTc-.DtFhhLhSKVEp..EcIhchhpNLoSlQALEGSRELENlIGlSpsSp.LptEhpKTptLMops.c.pLhc+.pstlPt+t......	0	1	1	5
+6558	PF06730	FAM92	DUF1208;	FAM92 protein	Moxon SJ, Eberhardt R	anon	Pfam-B_23546 (release 10.0)	Family	This family of proteins has a role in embryogenesis. During embryogenesis it is essential for ectoderm and axial mesoderm development [1]. It may regulate cell proliferation and apoptosis [2].	23.60	23.60	23.60	23.90	23.40	23.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-5.01	3	180	2012-10-03 12:17:00	2003-07-30 14:52:42	6	5	78	0	107	155	0	185.00	52	69.77	CHANGED	MhRRs....L-sRDAQTKQLQ-AVoNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINuYAuTETPNLKL..GLKsFADEFAKLQDYRQAEVERLEAKVVEPLKsYGTIVKMKRDDLKATLTARNREAKQLoQLERTRQRNPSDRHVISQAETELQRAsMDAoRTSRHLEETIsNFE+QKlKDIKsIlSEFITIEMLFHGKALEVaTAAYQNIQNIDEDEDLE	..................................R-sQs+.lpsslsNsEKHFG-hCplFAu.YsRKTARLRDKuD.......LVppl.tsYAsoEs.P.pL+h..GL+sFA-...chAKl.QDYRQAE........VE.RLEuKV.VpPLKtYG..sllK.pR--lKtshpARs+EhKQhppLE+hRQ+sPS.D.Rp.h...I.s..p...AEo-Lp+AshDsoRoo+pLEEs.......lssFE+QKl+DlKpIhu-FlpIEMhFHuKALEVhosAaQslpplD.-cDL..............................	0	23	29	51
+6560	PF06732	Pescadillo_N		Pescadillo N-terminus	Moxon SJ, Wood V	anon	Pfam-B_77615 (release 9.0)	Family	This family represents the N-terminal region of Pescadillo. Pescadillo protein localises to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest [1]. This family is often found in conjunction with a Pfam:PF00533 domain.	25.00	25.00	32.10	32.10	23.40	21.60	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.89	0.70	-5.15	9	361	2009-01-15 18:05:59	2003-07-30 15:27:31	6	7	309	0	244	367	12	258.90	46	46.38	CHANGED	KpKhcpGsAspYlTRppAl+KLQLoLsDFRRLCIlKGIYP+EPK+.KKKsNKGSot.+saYhtKDIpaLhHEPIlpKFR-YKlFh+Klp+Ah.u+t-hpssK+Lhss..+PsYpLDHIIKERYPTFhDALRDlDDALSMlFLFSshPsop+..........lpsphlppC++LssEahpYVhco+uLRKsFlSIKGlYYQAElhGpclTWllPa..tFspshsoDVDF+VMhTFlEFYpsLLuFVNFKLYpsLsLhYPP+l-sphcppttst.uhcht.susphshths.stpttcsh	..........KKhppGpApsYITRspAl+KLQlSLsDFRRLCIhK...........GIYP.REP+p......KKK.ss.KuuosspTaYahKDIpaLhHEPllpKFR-hKsah+Kl.p+Ah.u+s-hssscRLccN........+PpapLDHIlKERYPTFlDALRDLDDsLohlFLFushPs.ssp...................l.sph.lphCpRLshEa.tY.lhts+uLRK....sFlSIKGlYYQApl.......Gp.....p..lhWlsPa..pF..spp.hs..sDVDaRl..MhTFlEFYpT..LLuFVNF+LYps...l..sLh.Y.PPpl-tptpptt..t.thtsh.......h..........................ttt.t.............................................	0	91	139	204
+6561	PF06733	DEAD_2		DEAD_2	Vella Briffa B	anon	Pfam-B_1713 (release 10.0)	Family	This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.63	0.71	-4.86	33	3488	2012-10-05 12:31:09	2003-07-30 16:01:32	10	48	1979	5	1199	2928	287	131.00	24	17.76	CHANGED	YsSRTHoQlpQslcEL++l.thh................hpsls.LuSRcplClpsclpc.tt..tpsls...thCpphtpph...........................C.aapsh.....ph.t....pphhhsslhslE-Lhc......hGcptphCPYass.RchlppA-lllhsYpYLlssphRpth.......lphcsslVIlDEAHNl.csstp...hhShclopppL	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s......h.t..........C........Pa...........h.......h......u....Rc....t......h..............p...AD........VV..lss...ap.h.l.....h.s..s.h..h..t..ctsh....................s.c.s...p......l.l.......l.........hDEAH..pLs-hupp..hhuhsls....................................................	1	423	690	993
+6562	PF06734	UL97		UL97	Vella Briffa B	anon	Pfam-B_1747 (release 10.0)	Family	This family represents a conserved region within viral UL97 phosphotransferases. UL97 participates in the phosphorylation of the nucleoside analog ganciclovir (GCV) to produce GCV-monophosphate [1].	25.00	25.00	43.90	42.60	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.24	0.71	-4.92	8	208	2012-10-02 22:05:25	2003-07-30 16:47:50	7	1	30	0	0	154	0	170.10	60	38.99	CHANGED	NlLIsss.cssppIh+AVLCDYSLSEsHPp.aNcRCVVVFQpT+TlRhlPsSpa+Ls-hYHPAFRPlsLQKllll-P+ApFPss.uspRaCss-LCALGpVlsFCLlRlLDcRGhccVRtssEstLFphAspACcAhtpcclsuhuDAChhlLAcQLuYhusLLG.--ss-hhs+hhcFlcsps-ps	.NVLIcVNPHsPSEIlRAALCDYSLSEPYP-.YN-RCVsVFQETGTARRIPNCoHRLRECYHPAFRPhPLQKLlls.-.P+upFPss.uhpRaChS-LsALGpVluFCLhRlLD.......+RGhcEVRhsoEshLFthAstACRALtptplscsuDAChLlLAtQhuYsAsLLG.-cssslhu+hhcFlEs+hsp.........	0	0	0	0
+6564	PF06736	DUF1211		Protein of unknown function (DUF1211)	Vella Briffa B	anon	Pfam-B_2594 (release 10.0)	Family	This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.	25.00	25.00	29.00	25.60	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.05	0.72	-3.84	95	961	2009-01-15 18:05:59	2003-07-30 17:11:10	6	3	572	0	286	777	47	86.70	33	41.94	CHANGED	pRl-AFoDuVhAIhhTllVL.............-l...........................phPp...........sthhpsLh.shhsphhsYllSFlhluhhWhsHHphaphlp..plsptllhhNhhhLhhls..LlP	............................pRl-AFoDuVlAIlhTllVL.............-l...........................phPp...................ssshpuLh..phhsp.hhsYllSFlhluhhWhsHHpl.Fp.hlc..clstpl.hhhNhh..hLhhlohlP...................................	0	97	171	217
+6565	PF06737	Transglycosylas		Transglycosylase-like domain	Bateman A	anon	Bateman A	Domain	This family of proteins are very likely to act as transglycosylase enzymes related to Pfam:PF00062 and Pfam:PF01464. These other families are weakly matched by this family, and include the known active site residues.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.69	0.72	-3.68	18	1273	2012-10-03 00:09:25	2003-07-30 17:12:09	9	31	590	2	302	1024	36	75.60	45	27.18	CHANGED	sAssssWDtlApCESGGNW.ulNTGNGaYGGL.QFstuTWpuhGGspYus.sAstAoRppQIulA-+lhssQGhuAWPsC	..............s..ssssWDt..lApCESGGN.......W.ul.......N.....T.G.....NG.a.....a.GGl.QFstuTWpuhG.G..st.a.t..s....pss....tA........o+........p....pQ....IslAp+lh.......s.s.QG...hG...AWPsC............................................	0	77	214	286
+6566	PF06738	DUF1212		Protein of unknown function (DUF1212)	Vella Briffa B	anon	Pfam-B_1646 (release 10.0)	Family	This family represents a conserved region within a number of hypothetical membrane proteins of unknown function found in eukaryotes, bacteria and archaea.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.05	0.71	-4.84	181	3852	2012-10-02 11:53:07	2003-07-30 17:20:57	7	11	2765	0	655	2941	60	188.90	23	54.74	CHANGED	hGchLlpsGupshRVEcshpclu.pshGl..p.spshhsssulhloh.....ttsspshophppl.pspslshp+lsplpplscpltp..splsl.c-s...ppcLcpIpppt.....Yshhhhs.luhuluuu..uhshL.hGGs..hhchhhuhlsuhl......shhlphh.hs+tphsthhhp.hhuuhlsuh...........................luhhhh........th..shsh.shshh.hhuulhhLlPG	....................................................sGphLLpsGucshRV--shpRlu....p.s.h....G.h....sp..spshlsssuIhhoh...................sspsh.ophpcl..p..s.......pslshp+lsplpplscp..htp.............pp..l..sl..cps.......pp...cLppIptt..p.....Y.s.h.h.hh.s..lusu.lu.s.u..sFshL...h..G..G..s.....hhs.slhshluusl........................uhhlpth.l..s.+h..t..h.h...h.ls.....hl........uuhlssh...........................lu.hhhh......................ph..sh...s....t..s...s.hh...hhuulhhLVPG...........................................................................................................	0	207	396	545
+6567	PF06739	SBBP		Beta-propeller repeat	Yeats C	anon	Yeats C	Repeat	This family is related to Pfam:PF00400 and is  likely to also form a beta-propeller. SBBP stands for Seven Bladed Beta Propeller.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-7.54	0.72	-4.17	52	656	2012-10-05 17:30:42	2003-07-31 09:37:18	6	61	93	0	325	796	561	36.30	30	14.83	CHANGED	tahp..lG.......ssssps..spuIuhDppGN.lYlsGpTsu..sat	...............asp..lG............ss.ss..s......upu....lulD.ss.GN.lYlsGtTsu..sh.........	0	218	271	288
+6568	PF06740	DUF1213		Protein of unknown function (DUF1213)	Vella Briffa B	anon	Pfam-B_2177 (release 10.0)	Family	This family represents a short conserved repeat within Drosophila melanogaster proteins of unknown function. Approximately 50 copies of this repeat are present in each protein.	21.30	21.30	22.20	21.30	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.32	0.72	-3.84	29	411	2009-01-15 18:05:59	2003-07-31 11:07:59	7	12	12	0	314	459	0	29.70	64	20.54	CHANGED	KEsSRPESVsESlKD-s........tcs..cSRhESl	...KEsSRPtSVAESVKDEs............EKo.ttSRRESl..................	0	53	53	203
+6569	PF06741	LsmAD	Ataxin-2-like; Ataxin-2_N; 	LsmAD domain	Vella Briffa B, Bateman A	anon	Pfam-B_2543 (release 10.0)	Domain	This domain is found associated with Lsm domain [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.41	0.72	-3.88	26	396	2009-01-15 18:05:59	2003-07-31 13:05:57	8	12	263	0	244	409	5	70.30	42	7.87	CHANGED	FG.VpSTaDEcL..YTT+L-+uss.pa+ppppcA-+lA+EIEsp.sotshHlt-ERuh..h.s-sshDEE-pYSuVpRs	....aGVpoTYDpsL..YTs.L-+sss.pa+cREtcAsclA+EI...Euo..............sp.Rst.....htscsshs..EE-KYSuVpRp.............	0	77	130	192
+6570	PF06742	DUF1214		Protein of unknown function (DUF1214)	Vella Briffa B, Finn RD	anon	Pfam-B_2721 (release 10.0)	Domain	This family represents the C-terminal region of several hypothetical proteins of unknown function. Family members are mostly bacterial, but a few are also found in eukaryotes and archaea.	25.00	15.00	25.00	15.10	24.90	14.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-11.29	0.72	-3.56	331	1606	2012-10-01 20:00:45	2003-07-31 13:11:51	6	13	655	9	542	1441	270	108.30	21	30.86	CHANGED	ss.t-uhY.hh....st.hDssuph.....lsGst....t.apl......phs.s.thPss........t.FWSloh..Y....stt.......hhts....s....schs.............ls..s..............................ssDG.ohslhlu.s......ss.s.........................N..WL.................t.s................ahlhhRhYt..P.pp	.............................................................ss....tshY..h....s..hDssGp......LsGsp.......t.htl.....phs.s.thPss...........t.FWol..o.h....Ys.pt.h.....hhts.......s.........hsp.hs......lss.....................h..ssDG..olslhlusps..Pss.s...........N.Wl.....h.s.s.......s..hhlhhRhYh..s...tt.............................	0	109	283	416
+6571	PF06743	FAST_1	FAST_Leu-rich;	FAST kinase-like protein, subdomain 1	Vella Briffa B, Fenech M	anon	Pfam-B_2858 (release 10.0)	Family	This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis [1]. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.	24.80	24.80	24.80	25.30	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.09	0.72	-4.26	23	389	2009-09-10 21:09:11	2003-07-31 14:39:19	10	9	79	0	206	364	2	70.70	27	10.78	CHANGED	lssllhsFupLN..YcPsst-pFaspltptLpsphsths..PptllsllaSLshlppaPhshlsplhsssFlscL	.............ltpllhsFupLN..Y....p...P...s.pp.....c.p.Fh.....spltptLtpc..hsths......Ptt....llsllaSLshlpphP..phlptlhsspFlpph.....	0	32	49	104
+6572	PF06744	DUF1215		Protein of unknown function (DUF1215)	Vella Briffa B	anon	Pfam-B_2952 (release 10.0)	Family	This family represents a conserved region situated towards the C-terminal end of several hypothetical bacterial proteins of unknown function. A few members resemble the ImcF protein, which has been proposed [1] to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells line and increased conjugation frequency.	21.00	21.00	21.20	21.00	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.34	0.71	-4.48	111	1351	2009-01-15 18:05:59	2003-07-31 14:55:03	7	9	894	0	251	1140	28	123.70	27	10.91	CHANGED	lpphss........phPsslpshhsplsspuhphlhpsuts.pLsppWpspVhp.appsluGRYPFs.suspDlulsDFschFuss.GhlcpFhpppLtshlc.ssss.Wphcshss..sh.....slssshLpthppAppI	........................................................up........phPsPlpshlsp....lssp........uhphlht.tutp..lspp...Wpss..Vspsap..psluuRYPFs..sospDsols-FpcaFuss.GhlDsFapppLtshl-..ssss..ah.csssst...sh.....slpss.hLsthppAppI......................................	0	35	96	172
+6573	PF06745	KaiC		KaiC	Vella Briffa B	anon	Pfam-B_2234 (release 10.0)	Family	This family represents a conserved region within bacterial and archaeal proteins, most of which are hypothetical. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.26	0.70	-5.24	26	1953	2012-10-05 12:31:09	2003-07-31 15:32:50	8	20	758	154	980	16013	6155	206.50	22	73.85	CHANGED	lpTGI.GhD-lh.p.............GGlPcspslLloGssGTGKTlhuhQFLhpGhhchGEsGlaVolEEss....psl+cshc.phGWDlpchEccGhlsllDuhsssht............ptslcpLhppLppsl+chsA..+RllIDSlosL..hhppssh.sRphlhpLhphl.cthGsTulhsophs......stpshus.GVEc.slDGlIhLchcchst............chhRolhIhKMRuTsHshpcaPF-Ioc.pGIhlhsttt	......................................................oGl.tlDphl..t............................GG..l...ts..phhL.l....t.G.ss...GoG.K......T..hh....u......h.............p.........F.....l.........h...........p...............u.....h........p........p.............................u.......-............t..............s......l......a...l....s..h.c.....E..s........................tp..l.......h...p.....p..........h.........p.......s..h.......G.......h.........s........h........p.......t........h...................t..........p......t.............l......h....h.h..p.....h..st..............................................ph.p.t..h....h....p..t......l....t..p....t....l....c....p...h....p.s...........p..h.....l..l......l..D.....S....l........ss.........l............................h..........h............t.............s....................t...........t.........h.......+........p..............l........h.....p.......l.......h.....p....h.l.......p......p....h....s......h......o......s.......l...h..s.s...p.h.t................t.t..t..h..s..t..t..l......p.p.......l..s..Ds.l.lhLc....h.....tt..............................phtR....h.lplhKhR.s......s.t..t.t.t......t...h.h.aplsp..tGl.lh...h...........................................................................................................................................................................................................	0	262	574	792
+6574	PF06746	DUF1216		Protein of unknown function (DUF1216)	Vella Briffa B	anon	Pfam-B_3048 (release 10.0)	Family	This family represents a conserved region, within Arabidopsis thaliana proteins, of unknown function. Family members sometimes contain more than one copy.It has been reported that this domain will be found in other Brassicaceae.	19.70	19.70	20.40	19.80	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.93	0.71	-4.39	14	50	2009-01-15 18:05:59	2003-07-31 15:42:00	6	3	5	0	38	49	0	129.60	28	39.42	CHANGED	FFEpLKuhMph.ssh....t.pssKshps-MKupAstLhcAMuuhp....stSuchppplppph.phhKTLp.hp.h.tphh.t..tctcpptohphThpQppElcpslsKWppllopFVcosspspup..ShspSS.........ssssssSS	...........................FFppLKuaMphhsss....t.ssuK.sh.sch+upustLhcAMuuhp.uph.upSuc.ppplppshhphhKTl..h...h.t.h.....hc.cppustphThpQppElhpshsKWppslspFVcosspspup..S.s...uS...t...........s.t......tt........................................................................................................................	0	21	21	21
+6575	PF06747	CHCH		CHCH domain	Westerman BA, Poutsma A, Steegers E, Oudejans CBM, Bateman A	anon	Westerman BA, Poutsma A, Steegers E, Oudejans CBM	Domain	we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterised proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesise the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation [2]. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit [3]. The CHCH domain was previously called DUF657 [4].	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.01	0.72	-3.96	53	994	2012-10-02 15:44:21	2003-07-31 16:10:01	8	11	296	4	623	930	5	35.40	25	22.76	CHANGED	Ctt-hpphhpChppssp...p..hspCpphhpthpp.Chpp	..........CspchcphhsChppssp....p...hppCpct.pshpp.Chh.....	0	169	274	457
+6576	PF06748	DUF1217		Protein of unknown function (DUF1217)	Vella Briffa B	anon	Pfam-B_3199 (release 10.0)	Family	This family represents a conserved region that is found within bacterial proteins, most of which are hypothetical. Some members contain multiple copies.	22.80	22.80	24.60	23.00	21.20	22.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.89	0.71	-4.14	53	429	2009-01-15 18:05:59	2003-07-31 16:22:50	7	6	178	2	178	422	24	141.70	27	69.03	CHANGED	AaGL--.hhs+Ahl+KlLps..shs-ssoaAN+Ls.........Dp.RYpchusAFsFss.t....Gsh................................................sspssstt......................................................................................................................psssspYhppph-ppsGspspulRlALYFpRps.........sslso..................................shclLuss.............sLpphhpTuhGLs.sshushc...l-tQhthlcctl.......phschsD.Pppht	..................................................AaGL-s.thscuhl+KlLps..shsD......s....uhsNpLs.........Dp.RYtphApuFsFssp.Gsh.........................................................................................................................ss..Qopsth.....................................................................................................................pshhstYh........p....p.....s....h..-.p....psus......p.......sp....ss.c...........A.....h.....Yapcph...............sslss..................................s.-lLuDp.............tLhshhhsuhGls.sphst.t....................................p..............................................	0	36	78	108
+6577	PF06749	DUF1218		Protein of unknown function (DUF1218)	Vella Briffa B	anon	Pfam-B_3286 (release 10.0)	Family	This family contains hypothetical plant proteins of unknown function. Family members contain a number of conserved cysteine residues.	21.70	21.70	21.70	22.60	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.12	0.72	-10.31	0.72	-3.53	39	580	2009-01-15 18:05:59	2003-07-31 16:26:16	7	5	148	0	209	417	0	76.60	39	56.25	CHANGED	sAhlhLhhuQllssssstC....hCs...ups.......hhs.ttsp+shulhhhlloWlshslAhshLlsGustNuhpth........................s.sChhl+cGlFuuuAs.......lsLhsslh	...........................................psllhulo+C....hCh.....G+s..............lsP....uusRuhsllhFlsSW.lTF.........llAEuCllAGutp.NAhHs..............................................................................................	0	27	118	166
+6578	PF06750	DiS_P_DiS		Bacterial Peptidase A24 N-terminal domain	Yeats C	anon	Yeats C	Domain	This family is found at the N-terminus of the pre-pilin peptidases (Pfam:PF01478). It's function has not been specifically determined; however some of the family have been characterised as bifunctional ([2]), and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in [1], but their role was incorrectly ascribed. 	23.00	23.00	23.20	23.80	21.90	22.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.27	0.72	-4.19	156	2675	2009-01-15 18:05:59	2003-08-01 09:33:18	8	8	2521	0	532	1905	721	94.00	36	36.27	CHANGED	llG...hhlGSFLNVVlaRlP......tth.......................................slhhP............t.SpCPpCppplpha-sIPllSaLhL+G+.C+tCpstISh+YPllEllsullh...hhshhthuh	............................lhGhhlGSFLsVlIhRlP.......ht.h..............................................................slh.h.P.p.S+CspCpppl+hh-.IPllSa.L.h.L+G+.C......RpCp.spIuhpYsLlElls.u.llh.lhhhhhh..h....................	1	185	349	455
+6579	PF06751	EutB		Ethanolamine ammonia lyase large subunit (EutB)	Moxon SJ	anon	Pfam-B_6325 (release 10.0)	Family	This family consists of several bacterial ethanolamine ammonia lyase large subunit (EutB) proteins (EC:4.3.1.7). Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia. The enzyme is a heterodimer composed of subunits of Mr approximately 55,000 (EutB) and 35,000 (EutC) [1].  	25.00	25.00	31.30	31.10	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.43	0.70	-6.15	12	1141	2009-01-15 18:05:59	2003-08-01 09:56:23	6	3	1070	18	217	709	31	435.60	63	95.67	CHANGED	sYpFcsL+-VhAKAs.t+SGDpLAGlAAsSupERVAA+hlLuclsLpchhpssllPYEpDEVTRlI.Dshstttas.lpphTVu-hR-WLLscpss...ssplptlu.GLTsEMlAAVoKLMpN.DLIhsApKhcVss+hpoTIGlpGphSsRLQPNHPTDDPpGIsASlL-GLhaGsGDAVIGlNPssDossulsclLchh-clhp+acIPTQsCVLuHVTTphEAIcpGsPlDLlFQSIAGoEtuNpuFGlslAlLcEApphuLshpp.ssGsNVMYFETGQGStLSusAHaG.....VDQ.ThEARsYulA++acPhLVNTVVGFIGPEYLYDuKQlIRAGLEDHFhGKLhGlPMGsDlCYTNHhcADQsDh-NLhsLLssAGsNalMGlPsuDDVMLNYQTTuaHDshhlRclhGL+PhsEFEpWLpchGhhtt.sG+Ls.tuGssuhF	.......sYpFcslK-VLAKAs.hRSGDhLAGVAAsSupERVAAK.VLu-hs..............ls-............lhNsPVIsY..E..-DpVTRLI.DshscsAas..p..I+paTlu-LREalLS-c.To.....s.sc..lthlpcGLTsEhVAAVuKlMsNtDLIhuA+Kh.V..lp+hpTTIGl....PGshSsRLQPNcspDDlpuIAAplh-GLsaGsGDAVIGlNPVTDslcsl...s+lLchltslIp+asIP..T..Q..u..CVLAHV..TTQ..IEAI.cR.G.A.PssLlFQSIuGoEKuN.csFGlsL.............A.hL.cEA+tsuhphs.R..............h.......sGp.....NshYFETGQGSALSAsApaG.....sDQ.ThEARsYGlAR.......+a-...............P..............FL.............VNTVVGFIGPEYLYss+QIIRAGLEDHFhGKLhGlsMGCDsCYTNHA-ADQND.-NLhhLLusAGCNaIMGlPhuDDl.........MLNYQTTuFHDshslRplLsLRPuPEFEcWLEpMGIh...s..s.G.+LoppuG-ss................	0	60	124	172
+6580	PF06752	E_Pc_C	E_Pc_C-term; 	Enhancer of Polycomb C-terminus	Vella Briffa B	anon	Pfam-B_16811 (release 10.0)	Family	This family represents the C-terminus of eukaryotic enhancer of polycomb  proteins, which have roles in heterochromatin formation [1]. This family contains several conserved motifs.	19.70	19.70	19.80	20.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.56	0.70	-4.85	5	124	2009-09-11 20:40:39	2003-08-01 10:02:32	7	4	42	0	55	110	0	215.70	53	29.54	CHANGED	uFTAEQYQQHQQQLVLMQKQQLtQLQQpQQsssSosssss......................pulVSKTLDSASAQFAASALVTo-.QLLuhKSKE-sVhtsGVNGVVsuSGsYKuLHl................TsSAlsph..s..SuuSossuPosslsoSsupoossHtlsAhu...........sAosQsLhGNNlpLoVPosluTVssVoPlssRHlsRTLusVPsSALKLAAsANs..pVPKV.TuSSolD.luRENHEsEKPALNuLAENTVAMEVT	.......................uhTtEQaQpHQQQLs.MQ+QQ..LAQlQQp....Qts....ppSSppTp.p..............................shpshhSKTLDSASApFAASAlVou...hhu.thK-pssht..slNGVl.sS.G.......s.KsLa.................TshAL..............uSo.h.sus.h.posuHoshsH.l.sAhs...........ouosQsL.hNN..pLTsssplssVssluPlNs+h.sRT.u.s.s.P.oALKLA..ss..Ass...pVPKV..ssSSu..lsolsRENHEsE+.uLNsIA-sTVAMEVT......................................	0	3	8	22
+6581	PF06753	Bradykinin		Bradykinin	Moxon SJ	anon	Pfam-B_7085 (release 10.0)	Family	This family consists of several bradykinin sequences. The skins of anuran amphibians, in addition to mucus glands, contain highly specialised poison glands, which, in reaction to stress or attack, exude a complex noxious cocktail of biologically active molecules. These secretions often contain a plethora of peptides among which bradykinin or structural variants have been identified [1].	20.70	20.70	20.90	20.90	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.55	0.72	-6.57	0.72	-4.36	2	35	2009-12-03 16:03:04	2003-08-01 10:06:19	7	5	8	0	0	37	0	16.50	85	34.95	CHANGED	LQRRPsGFTPFRGKFHSQS	s...RPPGFSPFRGKFHSQS..	0	0	0	0
+6582	PF06754	PhnG		Phosphonate metabolism protein PhnG	Moxon SJ	anon	Pfam-B_6667 (release 10.0)	Family	This family consists of several bacterial phosphonate metabolism protein PhnG sequences. In Escherichia coli, the phn operon encodes proteins responsible for the uptake and breakdown of phosphonates. The exact function of PhnG is unknown, however it is thought likely that along with six other proteins PhnG makes up the the C-P (carbon-phosphorus) lyase [1].	25.00	25.00	26.20	26.20	23.70	22.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.69	0.71	-4.58	50	665	2009-01-15 18:05:59	2003-08-01 10:41:11	7	3	645	0	125	413	78	145.30	51	96.70	CHANGED	sshssRptWMulLA+A.....ssscLsshhsslsh....PsaphLRsPEsGhVMVRGRhGGoGusFNLGEhTVTRssV+Lss.....Gp..lGauYlhGRD+p+AElAAlhDALhQpsstt.......splpppllsPLttttsspctp+AAcsAATKVDFFTM..VRGED	...........................s.pAsRQ+WMuVLA+o.....pss....ELsA+hpA.L.sl....sssYclIRAsEoGLV.lpuRMGGTGcp.FhhG-sTlTRAuVRLsD..............................GT....l..GYSaVLGRDKpHAEtsALlD.ALhQps...c.ph.......psLpcsL..IsPLcAcphsRhAs...RpAE...lsAoRVDFFTM..VRG-s....................	0	22	66	91
+6583	PF06755	DUF1219		Protein of unknown function (DUF1219)	Moxon SJ	anon	Pfam-B_4928 (release 10.0)	Family	This family consists of several hypothetical proteins which seem to be specific to the Enterobacteria Escherichia coli and Shigella flexneri. Family members are often known as YeeV proteins and are around 125 residues in length. The function of this family is unknown.	25.00	25.00	28.30	25.80	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.38	0.71	-4.57	8	829	2009-01-15 18:05:59	2003-08-01 10:48:13	7	4	345	0	38	369	4	110.90	74	90.28	CHANGED	MpT.PssssptApsCPSPVsIWQpLLoaLL-QHYGLTLNDTPFuDEsVIpEHI-AGISLsDAVNFLVEKYsLVRIDRcGFSsppQSPhloulDILRAR+ATGLhppps..sl.........tt+	..................MKTLPsohsRtASpCPSPV.sIWQpLLoRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGFSsss.pSQLINSIDILRARRATGLMTRcNYRTVN.sIThG+ast.....................	0	3	8	21
+6584	PF06756	S19	S19_C-term; 	Chorion protein S19 C-terminal	Vella Briffa B	anon	Pfam-B_16839 (release 10.0)	Family	This family represents the C-terminal region of eukaryotic chorion protein S19. In Drosophilidae, the S19 gene is known to form part of an autosomal cluster that also contains s16, s15 and s18 [1]. Note that members of this family contain a conserved PVA motif, and many contain Pfam:PF03964.	25.00	25.00	110.80	110.00	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.76	0.72	-4.12	6	18	2009-01-15 18:05:59	2003-08-01 11:00:52	6	2	14	0	8	21	0	76.80	66	38.58	CHANGED	uuss.uGsYGGt....huPRaTVQPAGsTLLYPGQNSY+sYsSPsEYSKVlLPVRAAuPVAKLYlPEN...sYGupsGY	..............tuh..uGNYGtR.tGhhuPRWTVQPAGATLLYPGQNsYRsYVSPPEYSKVlLPVRsAuPVAKLYlPEN...pYGsQhs..........................	0	1	1	4
+6585	PF06757	Ins_allergen_rp		Insect allergen related repeat, nitrile-specifier detoxification	Moxon SJ	anon	Pfam-B_5947 (release 10.0)	Family	This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain [3].	21.60	21.60	21.60	22.70	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.95	0.71	-4.79	38	335	2009-01-15 18:05:59	2003-08-01 11:05:02	8	5	49	0	131	369	0	174.00	23	79.51	CHANGED	stsLpsDhp-Fl.sLlPhcp....ltplstcYhhsDschppslpYLpos-Fpplapplhs.hs-lpshlpalc..spGlslhs.......hlNplsshl...sls.l..........pPp.hh............pstulsuhlc-llulLPhcclpALap-Khps.os-Fpthactlpo.-Fpplhppht....ssp-lppllpcL+.cpGl...Dlcpllchl	....................................shptchp-Fh.slls..hcp....l.plhtpYhhpDschppslpal.pss.p...F..tphhpplts.hP-hp.slhsalp...ppslslst...........hl..cplpph.l.....th.ph......................s.s..hp......................pspshpsals-slslLP..hsplpuL..apcK.hps.sstFpphhcslpop-acplhpslh....pscphpslhppLp.ppul...clchlhp..h....................	0	31	38	108
+6586	PF06758	DUF1220		Repeat of unknown function (DUF1220)	Moxon SJ	anon	Pfam-B_6292 (release 10.0)	Domain	\N	20.30	20.30	20.60	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-9.07	0.72	-4.17	15	961	2009-10-27 09:18:29	2003-08-01 11:14:26	8	17	26	0	206	961	0	64.40	48	40.55	CHANGED	EE..-QpPssPRLs.....tEL.-sEE.EVLQDSLDcChoTsSshh-ls-SsQPYcSsFaohEEpcVuhALsVD	...................EE..-QsPssPRLS....................pELh-scEs.EVLQD...SLDcCYSTPSshhEhsDSsQP.YpSs.ha.o...LEEpcVuhuLDls................	0	156	156	156
+6588	PF06760	DUF1221		Protein of unknown function (DUF1221)	Vella Briffa B	anon	Pfam-B_16837 (release 10.0)	Family	This is a family of plant proteins, most of which are hypothetical and of unknown function. All members contain the Pfam:PF00069 domain, suggesting that they may possess kinase activity.	25.00	25.00	91.50	32.80	24.10	23.30	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.45	0.70	-5.09	5	29	2009-01-15 18:05:59	2003-08-01 13:54:25	6	3	13	0	22	30	0	205.70	50	30.18	CHANGED	+DDIp.INQRQCsLLLDlauLAacoVAsElRuNLRF-EKpTKWKsLEQPLRELHRVFREGEAYVRpC..LDPK.cWWAKAIshapNTDCVEaHIHNLLsCluVVlEAIEsAGElSGhDPDEluR+RLVaSRKYDK-WpDPKLFpWRFGKpYLVo+DlCuRhDpAW+EDRWlLlptLQEKKsSuSs...sLoKpE+RLADLLhKsL.ss.p..sGKLaPSSlLLGSKD	.......pD-lp.IN.RQCsLLh-hhshAapslutElRtpL+h-E+t.TKW+sLEpPLRELaRlh+-GEhYVRpC..L.-s+..s......WWu+Ahshppsp-CVEaHlHNLLhChslVlEAIEsAG.El.oG..D.-Eht.R.+RLlhucKYD.+-h.DP+LFp.a+FGKpYLloc-lssRh-tAW+EDRWlLhphlcE++tsuu........loKpE+RLADlLhtth..............GK.LaPuSlLlso.......	0	2	11	17
+6589	PF06761	IcmF-related	ImcF-related; 	Intracellular multiplication and human macrophage-killing	Vella Briffa B	anon	Pfam-B_3476 (release 10.0)	Family	This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed [1] to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.	20.20	20.20	20.30	21.30	19.50	20.10	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.89	0.70	-5.13	95	1440	2009-09-11 20:39:52	2003-08-01 16:13:50	7	11	892	0	268	1260	33	297.20	22	27.04	CHANGED	llssLsslpphstths....sssshhh.chGLapusplssssppsYpptLpphllPtlhpplpppLpssh.....................psscthYpsL+sYLMLs.cts...c.hcsshlpsahtp....pWp.pphsss....ht....pptLttHLstlh.............pts.tshshsssLlppARphLsph....shspRlYpplcpph...spthschsLsctsGss..........sstlF...........pppsspshtt.s..lPGlaTtpGacphFhsplsphspphtp-p.WVL.Gpt....t...sthsssshp........pLtpclpphYhsDYsspWcshLsslclt......shss........lspuhphLpsLuus.sSPLhpLlpslscpTpL	.............................................................hLs.lpp.h.t.tht..h..ctsshhh.chGLYpuppltststpsYhphL...pph...hLPslhppltptLpss.....................................................................ssscpthssL+sYlMLs...c......p........p..hs...s.thlp...pahtp..............pWp..p..phssp..............ht....pptlhtHlpthh..............................pts.....h.p.sp...plltps+p..Ltph....shtpRlYpp.lttp.h......st.............t.s....shsLtchl.Gss..........hstlF..............tptss.............lPshaT+pGapphh.tphpp.hsp.tttt-s.WVLsptt.............p...sh.sps.shp.................plppplpphYhsDYsspWpshlsslplp........shss........lspshp.hLphlsss.suPlhpLhpsltcpTp.....................................................................	0	40	100	180
+6590	PF06762	LMF1	DUF1222;	Lipase maturation factor	Vella Briffa B, Eberhardt R	anon	Pfam-B_3454 (release 10.0)	Family	This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [1,2]. The precise role of LMF1 in lipase folding has yet to be determined [3].	29.30	29.30	29.90	32.70	28.90	29.20	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.42	0.70	-5.67	25	402	2012-10-02 13:32:46	2003-08-01 16:39:26	9	7	240	0	234	358	72	338.00	35	69.50	CHANGED	auFtW-uLLLEsGFLulFLuPs................psssstlslaLhRWLlFRlhFGuGllKl.R........ssssW+-LTuLpYHaETQPhPsPlSaahHpLPchh++hpssusahsElllPaLlFsP.p.lphhuuslhlshQlhllloGNauFhNaLTllL...................shuslD.......DshLshl.hst......................................................................................................................................p.ss.t..........................................................................sss.sshhhhhlslhlslhlhsLSh........hslhshlstc......Qh..............................................................................................................................................................................Mppsh.ssa+lVNoYGuFuslT..+pR.ElllEGot-st.......ssWc.....................................EYEF+sKPGslpR........hPphluP.YH.RLDWhMWFAAhsstp...............................................tssWhhsFlt+LLps-ps.......sLsLLtcs....PF.sspP.......P.palRAphY..cY+Fosh.pchtpsGt........WWpRphlt.pahPslsLss	..................................................................................................................................................................h.FtW-shLLEsGFLslhl.us........................ths...ss.hlshh.hhRWLlFRl.hu.....u.GllKh.p........ts.sWh..sLTsh....aHaETQPhPsPhuaahH.p.h...Ph..h++hpshus...ahhpl..slPhh.hFhP..............p..ht..........hhuhhh.llhQl..hllhoGNasahNhLTlll...................shuhhD.......st.h...thh..hs..................................................................................................................................................................................................................................................................................................................................................................................................................................................h...s.hhht.hls.hhhthh..lhhlsh............ss..hshhu.p................p...................................................................................................................................................................................................................................................................h..ptsh.s.hplsNoYGh.Ftphs..................ptR.ElllEGotss..t................s.Wp.....................................-YEFhhKPG.s.pR........hP....huP.ap.RLD.W.MWFAAh.ssh........................................................ttsWhhthh.+LLp...sc.t.......sl.pLltp..s.....PF..p.pP..........P.palRuphYpYpFop....tt...tptt.......................WWhRphh.t.ahPsht...p.......................................................................................................	0	97	133	191
+6591	PF06763	Minor_tail_Z		Prophage minor tail protein Z (GPZ)	Moxon SJ	anon	Pfam-B_6085 (release 10.0)	Family	This family consists of several prophage minor tail protein Z like sequences from Escherichia coli, Salmonella typhimurium and Lambda-like bacteriophages.	20.00	20.00	20.10	20.00	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.25	0.71	-4.65	8	914	2012-10-01 22:58:23	2003-08-04 11:55:40	6	3	408	0	33	448	7	176.00	56	97.65	CHANGED	lKGLEpAIcNLsulD+phVPpASAhAlNRVAppAlStosppVA+ET........ulPhKLV+pRsRLp+Aosc.KspA+I+VNRGNLPAIKLGoApVRLS+R.....G.tu.h.htGSVL+lGpaRFpcAFIQQLsNGRWHVMcRlsG..............KsRYPIDVVKIPlAuPLTpAF-pphcRlhcp-hPKpLtaALppQLRLhLpR	...................................................................................lKGL-pAlcNLspls..+pAVPtAoAhAINRVAssAIupousQVARET........tV..RKLV+cRsR..L...p.+Aosc....pspAR.IhV.N..RG...sLPsI.K..LGps.....hhs.pR..............G......ptss.Sl..Lh.l.Gp+.R.h.sAFI.Q..p...L.t.NG....R.WHVMQRlsG......................KNRYP.I.DV....V.K...IP.hAs..P..L.spA..Fcpsh-...RI...h+EcLPKpLuYALppQLRhslKR.......................................................................................................	0	6	13	21
+6592	PF06764	DUF1223		Protein of unknown function (DUF1223)	Moxon SJ	anon	Pfam-B_6655 (release 10.0)	Family	This family consists of several hypothetical proteins of around 250 residues in length which are found in both plants and bacteria. The function of this family is unknown.	26.80	26.80	27.00	30.40	25.70	26.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.31	0.71	-4.50	72	362	2009-01-15 18:05:59	2003-08-04 12:34:50	6	3	322	1	146	334	61	196.70	33	76.90	CHANGED	VVELFTSQGCSSCPPADphLuc...Lupc.............s.sVlsLuhHVDYWDYlGW+DsFupstaTpRQ+uYuptt..stptlYTPQhllsGppphsGsctspltstlptttst....htlslphs..ts.t.plplpssssssht.........hplhlshass.ttssplp+GENtG+plsasNlVpshptl...utWsG.ts.shphsh....shsstts............tssVhlQp	...................VVELaTSQGCoSCP.PADphluclusc..............s.sVlsLuaHVDYWDY.lGW+DsaAsppaTpRQpuYs....p..th..stctlYTPQhllsGpsp........hsGsstssltstlsssttp.....sslslphp..tps...s..plslslssst.tst................tshclhlshaps.shssp.lpcGENtG+slsapplVpshppl...uhWsG....tshph.p.lsh..s...tt.ts...........usslhlQ..........................................	0	36	85	111
+6594	PF06766	Hydrophobin_2		Fungal hydrophobin	Vella Briffa B	anon	Pfam-B_3587 (release 10.0)	Family	This is a family of fungal hydrophobins that seems to be restricted to ascomycetes. These are small, moderately hydrophobic extracellular proteins that have eight cysteine residues arranged in a strictly conserved motif. Hydrophobins are generally found on the outer surface of conidia and of the hyphal wall, and may be involved in mediating contact and communication between the fungus and its environment [1]. Note that some family members contain multiple copies.	21.20	21.20	21.40	26.10	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.96	0.72	-4.29	45	136	2009-01-15 18:05:59	2003-08-04 13:34:33	6	3	55	24	75	116	0	64.80	45	56.32	CHANGED	hCP.uG.Laus.PQCCuosVLGlAsLDCpsPsssssssssFpshCAut.GppspCCslP.lsGQulLCpsP	..............Cs.uG..Laus.PQCCuTDVLG.lAsLDCtsPspssssussFpshCAsh.Gp.p.ApCCslP.lh....GQulLCpss.............	1	9	33	59
+6595	PF06767	Sif		Sif protein	Moxon SJ	anon	Pfam-B_7884 (release 10.0)	Family	This family consists of several SifA and SifB and SseJ proteins which seem to be specific to the Salmonella species. SifA, SifB and SseJ have been demonstrated to localise to the Salmonella-containing vacuole (SCV) and to Salmonella-induced filaments (Sifs). Trafficking of SseJ and SifB away from the SCV requires the SPI-2 effector SifA. SseJ trafficking away from the SCV along Sifs is unnecessary for its virulence function [1].	27.60	27.60	28.20	28.40	26.90	27.50	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.16	0.70	-5.67	4	347	2009-01-15 18:05:59	2003-08-04 13:38:12	6	5	122	2	7	127	0	249.90	46	72.77	CHANGED	MPITIGNGaLKSEIhIsPPupT+EsWWKlLWE+lKDaFFSTG+AKADShlHEMLFuDsPPTRERLs-IFFELKALACASH+DRFQVYNPHEsDuTIIaRIhDENtcsELLRITQsTDTFSCclMGcsYFLh+-pPslLKSaPQMThTINKRYSElV-.sLPSTLCLpLAGsPhLSVPLcNI.tYLYSEhcKsNLDEWKsQEKssYLAsKIpSGIEKsh+hLpHANISESTQQpAFLETMoMCGLKslETsPP.THIPI.KhVcEVLLADKtFpsFLsoDsssSQSMLAEIIEsISDpVF+ALFRhDPQAIQKMAEEQLTTLHlRuppQpGs.LCCFL	...................MPITIG.pGaLKSEIh...opssp...soKES...a...a...pl.LWEKIK...DFFFoTt+AcADpCI+ELh.a.spp.sPTspRL..p-lFhcL+ELASsSCR-pFpl.s.casDspI..Ihp..h.D.pN.sEN...LpIh.ppDta.h-lMsphhhhhcs.psshLK.a....sphshhhpphhs....E.lsh.hPppL.Ls.uGu.h...hsVsLcNIcthLhs.hcKGpLstWKtQE+hshluu+Ip.GItps......ssIs-uhppph.hhcsht.ssLKphth.ssasp.slpphV.psLhtschh.shL.pss...Sts..hLs-lhEhlu.pVapulFp.s.p...................................pp.......................	0	0	0	3
+6597	PF06769	Plasmid_Txe	DUF1224; 	Plasmid encoded toxin Txe	Moxon SJ, Mistry J	anon	Pfam-B_7662 (release 10.0)	Family	The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair.  When the plasmid is lost, the antitoxin (Axe) is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth [1]. This family contains many hypothetical proteins. This domain forms complexes with Axe antitoxins containing Pfam:PF02604.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.69	0.72	-4.16	13	1544	2012-10-03 00:18:00	2003-08-04 13:57:46	8	6	1142	20	262	983	101	78.40	41	89.94	CHANGED	FTp-uW-DYhaWQpsD+Khlc+IN+LIc-spRs.PFcGIGKPEPLKtcLoGaWSRRIscEHRLVYhls....DsplsllusRYHY	...................................as.puapD.Yh.aW..p.p.p.D.+.+.h.l.K+Isc....LIc-.lp...R.s......P..a.p......G...h..G.KPEsL...K.t.s.Ls..G.h...WS.RRIs.cc.HRLVY.p..V..s.....-..c...p...l..h..I..h..us+h.HY.....................................	0	87	185	230
+6598	PF06770	Arif-1		Actin-rearrangement-inducing factor (Arif-1)	Moxon SJ	anon	Pfam-B_6086 (release 10.0)	Family	This family consists of several Nucleopolyhedrovirus actin-rearrangement-inducing factor (Arif-1) proteins. In response to Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) infection, a sequential rearrangement of the actin cytoskeleton occurs this is induced by Arif-1 [1]. Arif-1 is tyrosine phosphorylated and is located at the plasma membrane as a component of the actin rearrangement-inducing complex [2].	21.10	21.10	22.30	22.00	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.80	0.71	-11.43	0.71	-4.94	17	37	2009-01-15 18:05:59	2003-08-04 14:04:58	6	1	34	0	1	39	0	193.90	30	63.07	CHANGED	hsplhhhV...........hulhGslsp+aAlLl-hE.sspuVhNhShl.shlaGshlhhssshshhthh......tchp.........pshYhpshlsllshhshlphhlFlsh.s.lhc.GHlPsLDshhRcYDpcSlCWsGls......htDsNul..........sp..NChhh........shh..hhCltCRhEhhpcEPThhpppphslhhhslhllllpsashal.hcchpp	.........hhhh......h....hshhshlhulhGhhsscaAlLl-hE.sspuVhNhSsh.hhsaGhhlhhsshhsl..hh...............sphp......pshYhthhhhlhsslshlphhlalsh.shlhc.GHlPsLDVhhRcYDh-uhCWsGIV.....hhDsNsI.........hsp..NChhh........shhhhCstCRt.hhpsEsThhpppphslhhhlhhlhslpsasLah.hpchh.t..........	2	1	1	1
+6599	PF06771	Desmo_N	1111; Desmo_N-term; 	Viral Desmoplakin N-terminus	Vella Briffa B	anon	Pfam-B_3693 (release 10.0)	Family	This family represents the N-terminus of viral desmoplakin. Desmoplakin is a component of mature desmosomes, which are the main adhesive junctions in epithelia and cardiac muscle. Desmoplakin is also essential for the maturation of adherens junctions [1]. Note that many family members are hypothetical.	25.00	25.00	74.70	73.50	23.40	18.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.99	0.72	-4.06	20	59	2009-01-15 18:05:59	2003-08-04 14:20:02	6	1	52	0	0	60	0	86.30	44	11.83	CHANGED	+Y+GsDVs....spTVpNLL+TIsohSpps+s..ssss-hlp+IRsIIlhaRPsLpp.p.scLs.sscLllcuLps..sss.......+pI...THNaNYKYDYN	....+YtssDVs....spTVpsLLpTINoMSpRsKs..sss-chLp+IRsIIlhaRPpLps.+.hDLp.lPpLlhpuLts..sss.......ppI...THNaNYKYDYN...	0	0	0	0
+6600	PF06772	LtrA		Bacterial low temperature requirement A protein (LtrA)	Moxon SJ	anon	Pfam-B_8368 (release 10.0)	Family	This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes [1].	21.60	21.60	21.70	21.90	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.01	0.70	-5.54	9	969	2009-01-15 18:05:59	2003-08-04 14:56:32	6	11	713	0	309	814	19	321.40	22	81.25	CHANGED	pc+so.hELFFDLlFVhAlsQlo+tLhpshshstus.....phllhhhulWWsWhppoahsNhhss-ph.sRlhhhs.MhhsllLusulstsF.....psps.hhFsluYshMplupul.aLhAs+.ttshusppshhplushlhluulhWlsuuLh...tstRhhlahlulsl-hhsPh.......hstpshcph.lchtHlAERhuLhsIIsLGEol....lslssshhphshshtshhhhh.uFlsslshWhlYFtpstptss++tpssu.......hhasYuHl.IsuuIhlhuVu.-hslppshscshhtthh.....huusllFLhGhhhhptshtttthss+hlshshL......hLhsshLsshhlpshssllhlsVAhh.hss	....................................................................................pps.shhELFFDLlFV..h....Al....s....p..hsph...lhpt.st.h.h...........pallhhhhlWhhWhtpohasNta..sp.s.....s...h...h..hh...h...h...hhp...M...hh..hl...hh....u...s...u......l.....s.........s..a................................ppph......hh.F...h....l.........s....h..s..h.h..pls.h.sh.p.a......l...h.t....h...p......hs..s.t..c....t...s..h.....h..t....hs..h..h.h...h.l.s..s.h..h....h..h........hu..h....h...h..s.........tth....p.......h....h...h..h...h..l...u..l...h...l.p...h..h.s.sh.....................................ht..p..h..h....t...h.h......s...l...p.h....Hls..ERhuLhsIIhh....G...Esl...................l....u.ls...s....s.....h....h.......t........h.....s.....h...............h.....h.....h.....h.....h.......th.....h.....l.....hhs......lahh...Y.a.....s.....p...p.h..h.s..c..p.h.p.p..ts...............hhh.hY.s.H.h.lh.........hu.l..hh...hs.su.h.t...h...h...........t.......t........h......t.....t....h............h............h...h........................hhu.hh...l.a..hh....u..hh...hhh....h.......h..t...h...........p..hh....hh...........hhhh...h.l..............h......h...........................h....................................................................................................................	0	85	174	256
+6601	PF06773	Bim_N		Bim protein N-terminus	Moxon SJ	anon	Pfam-B_8427 (release 10.0)	Family	This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death [1].	19.10	19.10	19.90	44.30	18.40	16.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.97	0.72	-4.21	2	63	2009-01-15 18:05:59	2003-08-04 15:02:05	6	2	30	0	17	67	0	37.00	90	23.84	CHANGED	QPSslSs-Csp.EGGQLQsspR..phRP...GAPTSLpo..	QPSDVSSECDR.EGtQLQPAE...R..PPQLRP...GAPTSLQTEP.	0	1	1	4
+6603	PF06775	Seipin	DUF1226; 	Putative adipose-regulatory protein (Seipin)	Moxon SJ, Coggill P	anon	Pfam-B_8703 (release 10.0)	Family	Seipin is a protein of approximately 400 residues, in humans, which is the product of a gene homologous to the murine guanine nucleotide-binding protein (G protein) gamma-3 linked gene.  This gene is implicated in the regulation of body fat distribution and insulin resistance and particularly in the auto-immune disease Berardinelli-Seip congenital lipodystrophy type 2. Seipin has no similarity with other known proteins or consensus motifs that might predict its function, but it is predicted to contain two transmembrane domains at residues 28-49 and 237-258, in human, and a third transmembrane domain might be present at residues 155-173. Seipin may also be implicated in Silver spastic paraplegia syndrome and distal hereditary motor neuropathy type V [1].	19.20	19.20	19.70	19.20	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.08	0.71	-4.80	30	347	2009-01-15 18:05:59	2003-08-04 15:05:20	9	9	225	0	212	337	0	188.80	26	50.23	CHANGED	shhhllhlu....lhhY..........ssaYYsalPp..lshpcslahpassss...................PhAplsls.........................tphlhs....sQsYclslcLchP-SshNh..plGhFhVslsh...............................hopsups..................ls.............posRsshLpYcSshlchhpolhhhPhalhGhp.......cEpQplpVphhp..ca.cs............tsPssu.................................................lplplps+p........hQlYsA.pLplpAchsGlRalhYsa.lhShlVhsssha	.................................................................s..hhlhhhu....hhha.h.hY.htahPp...lth.pslahp....appsp..............................PhApssls......................................................................................................................tphlhh........sQsY..clslpLph.PcSshNt......plGh...Fhl.shph...........................................................................hstssph..........................................ls............posRssh........LpYc..Sshlphhps.hhh...s.....hhlhGht.......pppp.hlplphhp....ph...p...t..........................ssss.................................................hhlplpspt................hpl.YsA.plplpAchsGl.R........hlhapa.hhoh.hlhh......................................................................................................	1	72	124	175
+6604	PF06776	IalB		Invasion associated locus B (IalB) protein	Moxon SJ	anon	Pfam-B_3703 (release 10.0)	Family	This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions [1]. The role of this protein in other bacterial species is unknown.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.30	84	752	2009-01-15 18:05:59	2003-08-04 15:18:53	7	2	278	12	212	542	263	127.70	25	66.93	CHANGED	ausWsltCtpstt..spp............CplhQ.ltsp.psphlhphslhphss.....t.sssh..hplhlPhGhhLssGlslplD......ssp.stp..hsashChs.....sGChApls.lssshlsth+...pGspsslshhssss........ps.lslslo.L....pGFssAhcsls	............................................................................................tsWphhCsptt.....spp...............CthhQplhs....p......p.s...ph..s.hs..h.slhphts................t.tphhhhl.hhPhGhhlssGltlplD.................stp.hhp.....htas.hChs.....suChApss.lss.cllssl+...pG.p.s.hslphhssss........ps..lshsls.L......pG.FutAhssh................	0	35	108	144
+6605	PF06777	DUF1227		Protein of unknown function (DUF1227)	Vella Briffa B	anon	Pfam-B_3660 (release 10.0)	Family	This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).	20.30	20.30	21.20	22.70	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.68	0.71	-4.50	30	339	2009-01-15 18:05:59	2003-08-04 15:21:32	6	14	283	0	228	329	6	141.90	50	19.11	CHANGED	pplpclKpsDpp+Lp-EYc+LVcGLcpus..scp.t-.hhss....PVLP--...lL.........cEAV.PGNIR+AEHFluFL+RhlEYLKsRl.......+lp+VlsE.......................oPhoFLp+lcc.................pstI-pKsLRFCuERLpsLlpTLcIsclc-assLphlAsFATLVuTYpcG	..............................p.plpchKpsDtp+LpsEYp+LV-GL......+pAs....s...Rp....pDthhuN..............PlLP-D...lL.............pE.AV.PGNIRpAEHFluFL+RhlEYLKs.Rh.........+VpHVlpE..................................oPsuFLpclpp.................hshI-+KPLRFCuERLpSLl+TLE.....ls....-.lpD.assLp.lAsFATLVuTYp+G................................................................................	0	80	129	194
+6606	PF06778	Chlor_dismutase		Chlorite dismutase	Vella Briffa B	anon	Pfam-B_3770 (release 10.0)	Family	This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyses the disproportionation of chlorite into chloride and oxygen [1]. Note that many family members are hypothetical proteins.	25.00	25.00	26.10	25.80	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.27	0.71	-4.60	15	1117	2012-10-02 00:20:33	2003-08-04 15:31:48	7	6	979	83	232	766	77	187.80	35	69.25	CHANGED	--RpuhlsEhpsh.hpph...pcptcus.tslYslsGh+AD..lhlahhppsh-cLpplpscFp+op.luchshssaShlSlhc.SsYhs..............psclpupLhsclP...t+YlshYPMsKsh....sWYhLPhE-RcclMc-HGhhu+sassc..V+phhosShGlsDaEWsVsa-ucDltpapclVpchRhsEApp+hsc.tsPFhlG	........................................................................................pRtthhp-htphhpph.........tpp.ppss.puhYslsG.+AD..lhlahht......shcp.Lpph.scF.p+op....lu..ca.h.P..saShVulhc.upYht..................................sal..ApLhs.chP.....sca..lshYPhsKpt.....sWYhLs.EERp+hht...-...H...GhhG.Rp.Yss......V+p.hsuShuh..s...D...aE...Whlsh.u..-..-.lh..p..hhclhh-hRhsEspt.+.ht-..ssFasG.................	0	88	169	216
+6607	PF06779	DUF1228		Protein of unknown function (DUF1228)	Vella Briffa B	anon	Pfam-B_5646 (release 10.0)	Family	This family represents the N-terminus of several putative bacterial membrane proteins, which may be sugar transporters. Note that many family members are hypothetical proteins.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.84	0.72	-3.96	12	952	2012-10-03 03:33:39	2003-08-04 16:37:05	9	2	879	0	193	2042	466	85.10	42	22.01	CHANGED	sluMGlGRFsaTPlLPsMht-tthohusuualAoANYhGYLsGAlhAuhuhtt..up.RhhlhuGhhAoslLhhuMuhhsuhhshhl	................................luMGlGRFhYT.....P..hLPlMh....A.....-....s.....t..h.....o..h..sphua.lASuNY.sGYLsG.u.Ll.hu.hu...thc.........sc.h.+...h.L...h...s...uh...l.A...o..u..l..L.h..Lu.M.A.h.h.sshhlh......................................	0	27	80	135
+6608	PF06780	Erp_C	Erp_C-term; 	Erp protein C-terminus	Vella Briffa B	anon	Pfam-B_4561 (release 10.0)	Family	This family represents the C-terminus of bacterial Erp proteins that seem to be specific to Borrelia burgdorferi (a causative agent of Lyme disease). Borrelia Erp proteins are particularly heterogeneous, which might enable them to interact with a wide variety of host components [1].	22.80	22.80	22.90	28.60	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.10	0.71	-4.35	12	100	2009-12-15 09:40:32	2003-08-04 17:05:26	6	2	23	0	5	82	0	136.90	47	40.69	CHANGED	I+sLscKIDcINpDIDuIpspoo.........Vuuc-VhDKITGPlYDcFTDss...suIYpsW..ssLEp-.E-ptLt+LLcELp-sRssLRoKLNEuNp.h....htpsEPpLK-sVsVS-IKpDLEKLKSpLE-VKcYLcspsNFEEIKtYlpsS	......IcslscKIDcIsp-IDuIptpos............VuucEVcDKlTGPlYDchTDus......sSIYssW....ssLE.-.E-ptL..tcLl.cELp-sRssLRoKlpEu...h.....hpscsphK.-sV...pVu-IKpDLEKLKStLEcVKcYLcspsNFE-IKthlps......	0	5	5	5
+6609	PF06781	UPF0233		Uncharacterised protein family (UPF0233)	Moxon SJ	anon	SWISS-PROT	Family	\N	22.10	22.10	22.20	23.40	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.39	0.72	-4.36	23	435	2009-01-15 18:05:59	2003-08-05 10:43:42	7	2	428	0	115	274	249	89.00	38	89.48	CHANGED	MP+SKsR.p+ssp....sspssscsssphp..tssPsWasslMhuLMllGLlWllVaYlossp........hslssLG..sWNlslGFGlhllGhLMThRWR	.................................................................................MPcSKlR+pssh........psss...s..pR.ss.+.hps...sssssWasslhluLhLlGLlWLlVaYluusp............l..hhssLG...sW.NhsIGFulhhsGhlhohtW+......	0	36	85	106
+6610	PF06782	UPF0236		Uncharacterised protein family (UPF0236)	Moxon SJ	anon	SWISS-PROT	Family	\N	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	470	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.49	0.70	-6.07	4	519	2012-10-03 01:22:09	2003-08-05 10:45:30	6	3	191	0	142	510	9	310.10	18	93.00	CHANGED	MK.....pll...s.s.htp.h.h.EpLhcsshphpEL.pplhcplsKlhtElltthLEElDphltEs.RcKp+ahlccKc.p+sLhThhGsloFcRsYYhs+...E-G+a..saLLDcsLthscppRlocslchcsVEtAVp.sSYR+uucpltp.ss..hlS+pAl+phlhEss........ph..p.spp++VRhLYIEADt.ahuhQ...............ctputps+LlhIHEG...cp.susc.cLlNp+aahs...EuscDhWtclpcal.ppYch-shcc.lhINGDuAsWI+EGhp.ahs+upa.LDRFHLs+.lh+shS+pP+h+Ecsp....+tlpcsDccGlhtllpchhsstc-EpccccIpchh+hIcs..puI..R.YRc.........pGlpuhuAttplschaSuRlpphshuWScpGL+tMh+lhshphsGsshtclchsc+p....s.hthspcpItpApc+lppphs-plppth.slppG+hs.Iapsh.uL+.uthl	.........................................................................................................................................................................................................................h............................................................hh..hlpth...Dt..l.h........pp.............c...t...tt.aph......ppp...........+sl...hhhG.plpap.R..p..h.a..hpt.....ptt..p..........a..lDp.hth.t.h.tphs...h....hhp..u......sac.pss...h.............lot.tlhphl..ht.......................................t..h...........l...hlE...sDt.hl.........................t....t....t..................t...h......hh..p................................t..h.t............h................t............th......th.t.hh..pta.t.....t......lhh.uDuu..........h.....h.p.....t.h.....h.t...........h..........pt........a.....h.D.aHh.p.l........phh..t.................t....h.....t.hh......phl........p.....t.h...h.p.p....h...t................t...........t.....t.........p.h..t.hhphl.p..........h..................................h...hu.....t.....p...p..h.h..s...Rhptt.h.Wp.tGhp.h.thh...h....p..t................................................................................................hh..............................................................	0	43	92	104
+6611	PF06783	UPF0239		Uncharacterised protein family (UPF0239)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	47.30	46.50	24.60	24.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.76	0.72	-4.06	2	75	2009-09-10 19:00:48	2003-08-05 10:46:39	6	1	65	0	48	74	0	82.80	48	94.00	CHANGED	.u.shshS.schs-.shhp.LlRYGLalGAlFQhlCl.Ahll......ps.s.sSpPcouEVTc+.ttsV.oh.++.+K.pKKKR.	..........MuuplshSPPElPEPTahEsLLRYGLFlGAIFQLlClLAIIl..P........h.sK.Sc...c.s...-...s.....p.sS...-s...+...ou.Ess+.K...sK...s...s.ssphp.++sKKEsKKKR.............	0	7	11	30
+6612	PF06784	UPF0240		Uncharacterised protein family (UPF0240)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	25.70	25.30	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.07	0.71	-4.59	8	106	2009-01-15 18:05:59	2003-08-05 10:47:43	6	1	87	0	68	102	0	162.80	34	90.81	CHANGED	MG...uhluRtlRpFNlENRAc+hIS+pKPsPAPKHPSTpcsLccplopaP-lhcEls+KDspLLopLK-VYVsSpDshs.......pscuspspspsK.h+Ls+....-apashh-scslPKGKlolhEALpLlNNH+hpP-pWTAcKIApEY+LcppsVssLL+YFhTFEV+I.Pscs..K+slpo+	.........................................................MG...uhlsRhh+sFNlE...sRAcR.I.u+.K.....P..psAP+asos..p.h....pcp.hp.pPchtccls.pKDs.pL.hsh...LKcV.YVsSpDPss...........t.t..s.css.t..sp..p.p..+.hpl.s+................shpashh..p...pplP+...G+lolhpALp.......lLs..sHp......hpPppWT..A-KIApEY....pLc.....ccVpslLcYF.hsFpVhl...Pspp...pp................................	0	20	25	45
+6613	PF06785	UPF0242		Uncharacterised protein family (UPF0242)	Moxon SJ	anon	SWISS-PROT	Family	\N	24.30	24.30	24.60	25.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.34	0.70	-5.79	3	41	2009-01-15 18:05:59	2003-08-05 10:49:24	6	1	40	0	7	21	0	372.60	60	90.66	CHANGED	MLhVKKhlHsC.uRYapYLhPVVAlLLPLVCaPFLSpSQKhYGYFVFolISSLGWFFAIGRRE+QLKTAAGQLLQTKIRKLTEpDEGLRpIRESlEERQpESsQL+lQNQKLlNQLhHlRGVFlKTKG-hQKLEsLltHL+EENQCLQlQLDALlQECsEKpEEsQELNRELAETLAYQQsLNDEYQATFoEQHNMLDKRQlYIGKLEuKVQDLMCEIRNLLQLESsIsENLPu+sl.AsSp-lstQLlSELKKIAFKsENIEAASSLTASRYlRTDoSVHNYSLECRQLFDuLREENLGMLFVYAPQSQRAVFANALFKTWTGYGlEDFLKh-SDVVISGhsQWccDL+o.SRpERSGKIVIKTKu+GplPFYYCLssLNKGPLspHVLGVLYPl+t-sLpu	..........................hhhsKphhH.h.uRYapYL.PllAlLLPlssaPFLS-pQhhYu.FlFsllSSLGWhFAIGhRE+QL+sAAGQLLpsKIRKlTEpDEGL+pIREolEcRQpEoppL+lpNpKLlpQLhpsRp.VFhpsKG+hp+hEpLs++L+EENQpLQlQL-Ahs+EpsEK..EsQEL.pELpEsLAYQQpLpDEYQATFsEQHsMLDKRQsYIGpLEuKVQDLMCElRNLLQLE....utpp.NLPucss.....uSp-Vs.uQLl..Eh+KIVF+VEshEAAsSLTA.RYhRoDs......SsHNY.....SLsCRQLFDuLREENLGMLFlYAPhuQRlLFANuLFpsWTGYGlEDFLpc-SDVVlEGhuQWEcDLh.op.S.RsERSGKIVIKTKsaGshPFYYClssLsKGPFspHlLGVLYPA+hshhp............................	0	3	4	6
+6614	PF06786	UPF0253		Uncharacterised protein family (UPF0253)	Moxon SJ	anon	SWISS-PROT	Family	\N	21.60	21.60	21.70	46.10	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.12	0.72	-3.86	8	619	2009-01-15 18:05:59	2003-08-05 10:50:18	7	1	618	0	44	123	2	66.00	80	98.68	CHANGED	MphY..CEhlRchYupIGSGDtGYlPcAIsCAlKsLN-IAuD-uLPpcVREcAAaAAANLLlSDacDc	....MEKY..C.ELlRKRYAEIASGDLGYVPDALGCVLKVLNEhAAD-ALSEuVREKAAYAAANLLVSDYVNE..	1	3	11	26
+6615	PF06787	UPF0254		Uncharacterised protein family (UPF0254)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	109.70	109.30	22.50	20.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.92	0.71	-4.71	11	29	2009-01-15 18:05:59	2003-08-05 10:51:15	6	1	29	0	20	29	1	161.60	46	94.29	CHANGED	MIpVATAECFTHGKIGpcIHthApGY............chh.cashsh.p....hsVhVlAuhFIPolpGlcoLLshc.sPcP..chshc.hsKsYsEEpDhcVAphMAcAlKchhssDIuIGTTAGIG+GuIsIlo-cpphlhoSDlauDLhps..EpIhpRQcsGIp+ulchFhplLp	.MIoVATAECFTHG+IGhcIHthAsGY.....................ch...ch.hs..t.........tslpVluuhFIPolpulcolLslc..PEP..Dhshc.hsKsYsE-pDhcVAhlMAculKchhssDIuIGTTAGlGRGuIsIlT-csphlhTSDVau.DLlps..-sIhcRQcsGIcKulchhlclLp.	1	5	10	16
+6616	PF06788	UPF0257		Uncharacterised protein family (UPF0257)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	26.00	25.10	24.50	22.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.59	0.70	-5.13	5	467	2009-01-15 18:05:59	2003-08-05 10:53:10	8	1	451	0	19	170	1	225.00	80	98.48	CHANGED	VKKhlLlshLsllLsGCDNscuLlSFTPEMASFSNEFDFDPLRGPVKDFTQTLMNEpGEVoKRVoGTLSQEGCFDTLELHDLENNTtLALVLDANYYRDAEThEKRVRLQGKCQLAELPSAGVoWETDDNGFVVSAoGKEMcVpYRYDuEGYPLGKTTKosDpTLSVsATPSsDPRKKLDYTAVSLLN-+plGNVKQSCEYDsYANPVsCpLlIVDESVKPAVpR+YTIKNoIDYY	..........................hKh.LL.sLLshhLsGCDpscsh.SFTPEMASFSNEFDFDPLRGPVKDFTQTLMDEQGEVTKRVSGTLSEEGCFDSLELLDLEN...NT...l....VA.....LVL.DAN..YY..RDAETL.EKRVRL..QGKCQ.L.A.E.LPS.AG....V.S.W.ETDD.NGFV...IK...A..SSKQ...MQ.M...E...YRYDD.QGYPLGKT..TKSND..K..T.L..S.V.S.A..TP.STDPI.KKLDYTAVTLLNNQRVGN....VKQSC.EYDuHANPVDCQLIIV.D.EGVKPAVERVYTIKNTIDYY.................	0	1	2	10
+6617	PF06789	UPF0258		Uncharacterised protein family (UPF0258)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	65.00	64.80	21.00	18.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.92	0.71	-4.18	3	82	2009-01-15 18:05:59	2003-08-05 10:54:07	7	1	37	0	53	66	0	142.50	52	26.69	CHANGED	KDW......p+ccKcupsQtDpPGosusshpsKuusLVEQVFssHlaPQ.......uLoS+hKlNPLass.RhsEht-sGRGRPSWTl-DY...........A+spGccuRlTPL.DLQTQESL.......NPNNLEYWMEDIYTPGYDALLRRKEApLRRs+VCKlhALIsAAVsTlILVlVIPICTl+S	..........................................................Qh-....tt..hp......pps..h.l-pshssc.hPs.........SLpotMKsNPLYsDhRLsEhhE.++spPSWTIEEY.....................s+pu.pps+.sth.sLpsp.p........NPNsLcaWh-DlYTPGYDoLLK+KEsch+RuKlC+lhuLIhhussslILVllVsIsTh........	0	2	6	19
+6618	PF06790	UPF0259		Uncharacterised protein family (UPF0259)	Moxon SJ	anon	SWISS-PROT	Family	\N	27.90	27.90	27.90	28.20	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.69	0.70	-4.93	6	639	2009-09-11 20:38:19	2003-08-05 10:55:36	6	2	623	0	78	301	78	229.20	59	95.61	CHANGED	MsITspsLh+DTapFhpspIhsIlhlSlLuAFIollIshlhpPsstpLhslhp...shchpuopS.lh-llpsMol-QpplLL+hSlsppFSuLIGsshLlGulITlIshlSptK+h.SlhpuIshsh.hlP+LhlLhFlTThllQlGhhLhllPGIhluIlLSLSPIILshc+hslhsSI+hShpIoapNl+lluPullhWlssKhlLlhlhSpFslls.pluhlIhNhhhN.llouILIIYLFRhYML....LRs	.....................................................MSITApSVYRDoGNFFRNQFh....TIL..LlSLLCAFIT..VVLGH.s.FSPS..DAQlAQLs-....G.sl..u..GS..uG....LF-.L....VQNMoPEQQQILLpASAAS....TFSGLIG...NAILAGGlILl..IQLVSAG....pRV..SALRAIGA.SAP..l.LPKLFILIFLTTLLVQIGIMLlVVPGIIMAIlLALAPV.MLVp-.KM.Gl.FAuMRSSMRLs....W.A.N.MR.L.V.A.....PAV..l.....u.WLLAKTLL.L.LFA.o..S.FA.s...L..T..Pp...l.G..A.V.LANTLSN.LISAlLL.IYLFRLYML..IR.Q..........................................................	0	10	28	53
+6619	PF06791	TMP_2		Prophage tail length tape measure protein	Vella Briffa B	anon	Pfam-B_3868 (release 10.0)	Family	This family represents a conserved region located towards the N-terminal end of prophage tail length tape measure protein (TMP). TMP is important for assembly of phage tails and involved in tail length determination. Mutated forms TMP cause tail fibres to be shortened [1].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.17	0.70	-4.71	30	1212	2009-01-15 18:05:59	2003-08-05 10:57:24	8	8	525	0	82	1164	33	176.50	41	24.61	CHANGED	pptttshp+uGhSscphstAhRtlPAQhTDIssuLuuGpsshhlhhQQGGQlKDhFGGhGsAh+ulsshlhullsPhsl...uAA........usuuLuhAaYpGupEscpascALllT......GstAGsTuupLt...........shAcplus.ssuThusAupsLspL.....suoGphsupphptlupAssphp.csTGpul--hlppFs+LucDPlcAshcLscphpFLTsupYpQIpu	..........................................................................................................s....hthppAGhSstphthshp.......h....lstQhsDlsspLAsGps.hhlhhQQGuQ.......lts..ua....G....G..........h.........h.....htsh......uGhl...sh....Ms....sh.s.......hss................................AsuuLu..h.A...a.Y.p.G.......p....pp....h....ptFN+sLhLo..............G.s.uGh....Tu.sphh......................................shucuhpu..sGhT......p.psutsL.....u..tl..................................VtuGsh.sut.pht..lspusspht..pusG...p.Vscs.hptFt+L.psDPssuhhuhspph+.lTApQlt.lt.p..............................................................................................................................	0	6	36	56
+6620	PF06792	UPF0261		Uncharacterised protein family (UPF0261)	Moxon SJ	anon	SWISS-PROT	Family	\N	18.70	18.70	19.10	19.10	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.16	0.70	-6.00	49	512	2009-09-11 06:27:46	2003-08-05 11:40:03	6	9	446	0	153	391	143	339.40	39	90.09	CHANGED	tpplhllGThDTKscELpalpshlcs..........tGhsslhlDlu..shsssshss.....-lotp-VApstssshpslhss...tD.RspAhpsMucuhsthltphhcptplsGllulGGosGTuLsssuM+.uLPlGlPKlhVSTlA.SG..slssYlGssDIsMhhSVsD.luGLNpIo+plLuNAAsAlsGMs.shptsp.........................spKPhlGlTMFGVTT.ssVstlpstL-sp...GaEslVFHATGsGG+AMEcLscpGhlsuVlDlTTTElsDhlhGG.lhsAGs-...RhsAAu+sGlP.VlSsGAlDMVN..FGuhcTlPc+aps.....RhhatHNsplTLhRTos-Estpluchlup+LNp...spGsVthllPhtGlSslDt.GtsFaDs-ucsALhssLcpslps..shplhclstHINDstFAcssltthtchhs...p	.............................plhlhuThDTKspEhhaltph.ltt...........tGhpshhlDluhh.....t.......ts.........slstppVAtttst..sh...ttlhst........D.+spAhthMu.uhpthl.ph.p...........lsulluhGGosGTslhssshp..tLPlG.hPKlhVSThA..SG..ssssYl..GssDlsMhhSVsD.luG...LNplSRtVLuNAusAluGhst.t.h..p..pst...........................ppKP.hlGlTMFGlTT.PslpthpttLppp.....sY-slVFHATG.s.GG+uMEpLh.pp.thhsuVlD....hTToElsD.lhGG..Vhssssc...RhpshucstlP.lhusGAlDMVs..Fs.s.po...l.Ptpats...............R.hatHN..tlolhRoos-EstthuchlutKLst.........spu...lthhlP.tGhSthDt.Gtsaa-s....cA.tAhhp..tlctsl.t..........phplhchshpINcstFApthht.h.phh.p.........................	0	39	99	125
+6621	PF06793	UPF0262		Uncharacterised protein family (UPF0262)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	26.20	26.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.84	0.71	-4.51	24	243	2009-01-15 18:05:59	2003-08-05 11:41:08	7	2	240	0	86	194	178	157.40	58	97.24	CHANGED	hspsp.tR....LhclcLDEtolupssPDlEHERsVAIaDLlE-NpFs.Ps...Gst....sGPYpL+Lult-sRLlF-IpsEsss.lhsalLSLsPFRRllKDYFhIC-SYYpAIRouoPspIEAIDMGRRGlHNEGSplLp-RLpGKl-lDaDTARRLFTLICsLHh+G	...........................................................................................s...psRLscVpL.DE.oIuRuoPDl.EHERuVAIFDLlEEN.sFp.PsGcpt.......sG...PY+L+LSlh-sRLlFsIpp...EsG....ssl.ssHlLSLoPFRRlV+DYFhICESYYpAIRoA.oPSpIEAIDMGRRGlHNEGSpsLp-RLcGKl-lDFDTARRLFTLlCVLHW+G...	0	25	55	66
+6622	PF06794	UPF0270		Uncharacterised protein family (UPF0270)	Moxon SJ	anon	SWISS-PROT	Family	\N	20.10	20.10	20.70	20.90	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.03	0.72	-4.22	53	891	2009-01-15 18:05:59	2003-08-05 11:42:09	7	2	881	1	129	338	38	69.50	64	94.00	CHANGED	MI.IPap...pLss-TLpNLIEcFl...LREGTDYG-pEhSLppKlpplpppLcpGcsVlVaSELcE.....olsIhsKpph	..........Ml.IPWQ....-LuPETL-NLIESFV...LREGTDYGE+.Eco...LEQKVA-V++QLpsGEAVLVWSELHE.....TVNIMP+spF.............	0	19	51	95
+6623	PF06795	Erythrovirus_X		Erythrovirus X protein	Moxon SJ	anon	Pfam-B_9167 (release 10.0)	Family	This family consists of several Erythrovirus X proteins which seem to be found exclusively in human parvovirus and human erythrovirus. The function of this family is unknown.	21.00	21.00	21.10	182.00	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.69	0.72	-3.96	8	19	2009-01-15 18:05:59	2003-08-05 12:00:56	6	1	4	0	0	16	0	80.90	95	98.78	CHANGED	MDSYLTTPMPYHPVAVhQNLEEKMQYYLVKTYTSLGKLAYNYPVLTMLGLAMSYKLGPRKVLhTVLQGFMTLGIANWLSWE	MDSYLTTPMPYHPVAVhQNLEEKMQYYLVKTYTSLGKLAYNYPVLTMLGLAMSYKLGPRKVLhTVLQGFMTLGIANWLSWE	0	0	0	0
+6624	PF06796	NapE		Periplasmic nitrate reductase protein NapE	Moxon SJ	anon	Pfam-B_9066 (release 10.0)	Family	This family consists of several bacterial periplasmic nitrate reductase NapE proteins. Seven genes, napKEFDABC, encoding the periplasmic nitrate reductase system were cloned from the denitrifying phototrophic bacterium Rhodobacter sphaeroides f. sp. denitrificans IL106. NapE is thought to be a transmembrane protein [1].	25.00	25.00	30.30	29.70	20.70	18.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.69	0.72	-4.66	42	268	2009-01-15 18:05:59	2003-08-05 12:06:26	6	1	240	0	73	165	7	54.70	49	93.40	CHANGED	Mupssts......tpp+ppEl+sFlFLsshLaPlLoVshVuuYGFhlWhhQl.lhGP.PGt	..............Msp.s..ps....spc+uhEh+uFLFlsVlLFPlLSVuhVGGYGFlVWhhQh.lhGPPG.......	0	13	25	52
+6625	PF06797	DUF1229		Protein of unknown function (DUF1229)	Moxon SJ	anon	Pfam-B_9402 (release 10.0)	Family	This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.	25.00	25.00	400.70	400.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.67	0.70	-5.63	2	57	2009-01-15 18:05:59	2003-08-05 12:32:44	6	1	38	0	1	51	0	393.60	94	99.59	CHANGED	MSTHFSLKSASVITDYLFKFRIFSLPAICWICSTLIGFGTVNGRLSLFVIGLSFIISIFLLKNIKWNISSTFSFLLVISFLLAYFFFYKTPNMPQHLDGKLNPILYVFKAFPTLFSFFIIhALPSLKQKKLFFIGIALGMFVFAIINSIATLVYLEPPYYGKAYHFFYKMEYNSPGITILASMLPIVLFCFNGYLLKIDKKLKWQNlFFIFVFLISLFISFLFSARTLFFLIIANIIILVLIRLWKIYSIPNKGIYYKFIIGFLILFVSCSSIYFFLKETYIGQRIMNGIYSEKLNHHVDYWNTlKKDFFIYPKITIGSEYTFWYHNIFFDSHKTSGPITALILYIYSVFhFLIuLKKSLKRDYRSFRYFHFYICFIPYLMTTIPWESSESQMVALFAGLGALITTVDDQTPEM	....MSTHFSLKSA.SVITDYLFKFRIFSLPAICWICSTLIGFGTVNGRLSLFVIGLSFIISIFLLKNIKWNISSTFSFLLVISFLLAYFFFYKTPNMPQHLDGKLNPILYVFKAFPTLFSFFIIFALPSLKQKKLFFIGIALGMFVFAIINSIATLVYLEPPYYGKAYHFFYKMEYNSPGITILASMLPIVLFCFNGYLLKIDKKLpWQNVFFIFVFLISLFISFLFSARTFFFLIIANIIILVLIRLWKIYSIPNKGIYYKFIIGFLILFVSCSSIYFFLKETYIGQRIMNGIYSEKLNHHVDYWNTIKKDFFIYPKITIGSEYTFWYHNIFFDSHKTSGPITALILYIYSVFIFLIALKKSLKRDYRSFRYFHFYICFIPYLMTTIPWESSESQMVALFAGLGALITTVDDQTPEM...............	0	1	1	1
+6626	PF06798	PrkA		PrkA serine protein kinase C-terminal domain	Vella Briffa B, Bateman A	anon	Pfam-B_3917 (release 10.0)	Family	This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This family corresponds to the C-terminal domain [1].	25.00	25.00	25.50	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.61	0.70	-5.09	43	1353	2009-01-15 18:05:59	2003-08-05 12:42:19	7	5	1291	0	335	779	130	252.60	58	39.39	CHANGED	lpKh+lYsGEsl..hs.psc.slpEl+cpusp...........EGMsGlSsRalhctlupslsp...psppsslNPlplhppLEpslcp....tplspEs.cc+Ylc...hlc.hl+pEYpEhltcElp+Aah..uhcEthppLhspYl-plcAalpcp.......+l+Ds.TGc.h-PD..Echh+uIEEplGI.spptpcsFRpElhsal..uphsppG.cphsa.....ssaE+L+....cslE+KLaushc-hlplhohsup..hsDcEppc+hcphlpRh.pchGYs-psApcllca	................................................................hSKMRVYDGEoLK..DTDPKAK..ShQEYRDhAGV.......D...............EGMsGLS...TRFAFKILS+VFNF........D+s....EVAANPVHLhYVLEQQIER....EQFPpEp.tERYL-.....FlKsaLhP+YsEFIGKEIQTAYL.ESYSEYGQNIFDRYVsYADF.WIQDQ.......EYRDP.-TGplhDR-u...........LNsEL.EKIE..K.........P.......A.........G.........I...SN...........P....K.........DFRNE.IVNFVL.........RARAsNsG...+NPsW.......TSYEKLR...........sVIEKKM...F.S.N.T.E-.LLP.VI....S....FNAK...........sS....s--QKKH-DFVsRM..hE+GYTcKQVRLLsEW......................................................................................................................	0	95	195	270
+6627	PF06799	DUF1230		Protein of unknown function (DUF1230)	Moxon SJ	anon	Pfam-B_9232 (release 10.0)	Family	This family consists of several hypothetical plant and photosynthetic bacterial proteins of around 160 residues in length. The function of this family is unknown although looking at the species distribution the protein may play a part in photosynthesis.	25.00	25.00	28.90	53.10	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.92	0.71	-4.33	30	130	2009-01-15 18:05:59	2003-08-05 12:58:07	6	1	106	0	65	129	126	141.00	42	70.98	CHANGED	CPVP.-QpPlNEYppLpsSWhFoWsshsttsah+pLhhhWllshhlss.slAuuSashpcsshchllsusluuhllshLlllRlYLGWsYVtcRLhSpsVpYEESGWYDGQhW.KP.-hlt+D+LlupYpV+PlLsRLpp...ohshhs	.....CPVPhEQpPlNEYppLppShhFuWsshs..hhsa..ht+L...........shl.W.h.hs.hhlsu....Pl.Au.uSas..spppsl+hlLuussuuhhllsLlllRlYLGWsYVtcRLhStsV.YEESGWYDGQhWhKPsElLsRDRLluoYpV+PlLpRLppThsh.s........	0	17	44	58
+6628	PF06800	Sugar_transport		Sugar transport protein	Vella Briffa B	anon	Pfam-B_4126 (release 10.0)	Family	This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins [1], ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.90	0.70	-5.31	17	1288	2012-10-02 19:55:49	2003-08-05 13:02:27	7	5	732	0	128	848	304	260.80	40	91.36	CHANGED	hsllssKl.GGpPhpQhhGhTlGALlFulllhlhppsshs...phhlhullSGhhWulGQhhQF+uhchlGVS+sMPISTGhQLVGsoLhGVlsFtEWssshphllGhlAlllIllGhhLTuhpccpct..pp..pshp+ulhhLllSolGYhhYsll.sph......hslsGhsslLPQAIGMlluullhsh........chhhpKhohhNllsGlhWuhGNlhhlhSst..hsGlATuFSlSQhuVllSTlGGIhhLsEKKT++EhlhlhhGllLllluulhh	.............................................................................sllssKh.GGpPhpQhlGsTlGA.L.lFu...l...l...l.h..l...h.....s..p.....s..s.....h...s...........sslllu....llS.Gh.h.Wu.hGQhtQh.+uh.......p...hlGV..SpsMPl.ST.G..hQL...Vu..soLaGVlhh...t..E...Ws..s.h.......t.....p....h....l.l.Ghl.A.l.l.l..l.l.l.Gs.h.h.T.u.hp-cppt...........ts.......stsh.++u.l.h....h.L....l.l.S....ol.....GY..h...s.Ysll.sph..................hs...l.....s..........G........h.s.A.lL.P...Q..u.l..G.........M..l...l.u.......u...llhsh.................pch..h.h...p....K...h...o...h.h...N...ll...s.Glh.Wu...h.GN....L.h....h.llStt...tsGl..A.Tu..F.sLSQh.u.Vl.lSTLGGIhhLsE.....+..K.....T.....+...+...p...h....h...h...l....l...l...Gl..l..LIll.uull.h........................................................................	1	41	76	103
+6630	PF06802	DUF1231		Protein of unknown function (DUF1231)	Moxon SJ	anon	Pfam-B_9856 (release 10.0)	Family	This family consists of several Orthopoxvirus specific proteins predominantly of around 340 residues in length. This family contains both B17 and B15 proteins, the function of which are unknown.	25.00	25.00	105.70	105.60	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.28	0.70	-5.56	3	51	2009-01-15 18:05:59	2003-08-05 13:11:15	6	1	18	0	0	39	0	300.00	94	99.99	CHANGED	MSRKFMQVYEYDREQYLDEFIEDRYNDSFITSPEYYSAEKYMCRYTTLNHNCVNVRRCALDSKLLHDIITNCKIYNNIELVRATKFVYYLDLIKCNWVSKVGDSVLYPVIFITHTSTRNLDKVSVKTYKGVKVKKLNRCADHAIVINPFVKFKLTLPNKTSHAKVLVTFCKLKTDITPVEAPLPGNVLVYTFPDINKRIPGYIHVNIEGCIDGMIYINSSKFuCVLKLHRSMYRIPPFPIDICSCCSQYTNDDIEIPIHDLIKDVsIFKNKETVYYLKLNNKTIARFTYFNNIDTAITQEH-YVKIALGIVCKLMINNMHSIVGVNHSNTFVNCLLEDNV	..MSRKFMQVYEYDREQYLDEFIEDRYNDSFITSPEYYSAEKYMCRYTTLNHNCVNVRRCALDSKLLHDIITNCKIYNNIELVRATKFVYYLDLIKCNWVSKVGDSVLYPVIFITHTSTRNLDKVSVKTYKGVKVKKLNRCADHAIVINPFVKFKLTLPNKTSHAKVLVTFCKLRTDIT.IEAPLPGNVLVYTFPDINKRIPGYIHlNIEGCIDGMIYINSSKFACVLKLHRSMYRIPPFPIDICSCCSQYTNDDIEIPIHDLIKDVsIFKNKEhVYYLKLNNKTIARFTYFNNIDTAITQEHEYVKIA.LGIVCKLMINNMHSIVGVNHSNTFVNCLLEDNV.	0	0	0	0
+6631	PF06803	DUF1232		Protein of unknown function (DUF1232)	Vella Briffa B	anon	Pfam-B_4265 (release 10.0)	Family	This family represents a conserved region of approximately 60 residues within a number of hypothetical bacterial and archaeal proteins of unknown function.	20.80	20.80	20.80	20.80	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.68	0.72	-4.51	172	1698	2009-01-15 18:05:59	2003-08-05 13:26:27	7	20	1207	0	565	1384	202	40.10	37	27.25	CHANGED	htst.hh.lhuuLhYhlsPlDlIPD..hlsslGhlDDhsllshs	.............h.hs+hh.lhuuLsYhl.P....lDlIPD..hlsslGalDDlsllsh........	0	189	354	460
+6632	PF06804	Lipoprotein_18		NlpB/DapX lipoprotein	Moxon SJ	anon	Pfam-B_10405 (release 10.0)	Family	This family consists of a number of bacterial lipoproteins often known as NlpB or DapX. This lipoprotein is detected in outer membrane vesicles in Escherichia coli and appears to be nonessential [1].	20.00	20.00	20.20	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.65	0.70	-5.67	6	1056	2009-01-15 18:05:59	2003-08-05 14:05:53	6	3	1001	10	191	616	78	267.20	36	77.58	CHANGED	sYLcossLcshpsP....tsuhPph.ssYsIPQsshpGulGKpVDIRPPpQsLpLIsGARs-p..sGEsoLhLlcp-cts.clWppVtchLp-+pIPlpppsDut..lpTDWVsWsptDE-hphtuRYpIShhEsssppuhpVsLlsh+csstlpssshos+pRYNshMhNllouphDpshR-pApcpApchVppIslshGoDcoGhPllIsRuPYNVlWQRLPslLPKhGFsIc-RspSQGTlpsKYtussDc.WpplGsKs....-LKoGsYph.lGDLGNRoSlshTDssG+slspu.hcuLVsVLpAlls	.....................................................................................................................................................sYLpu.ssht.lp.sP...sGhh.h.Ph.......tss.........sYsI..P...s...s...p..s...p...Gu...lG...c.sl..D..I...R...P.P.......t..Q......s..LsL..l...s...Gu...R.sph.....sG-..su...l...l....l..c.....s.....s.....p.....s..s.....plW....spVhph....l....pt....+..s.hsl..pp..cs.Dus.....lpT.............D.......W..............l...........p.........W.s..............c........h.........D.............E................D.................p.......h.............c.u..R..Y..p..I....o...ht......p..shp..t..ulp..V....pLl....s.hc....p.........u..t.t........s....s...s...ss.....s..h...QR.....Y..............s...s...t...MhN.h.lsst...LDpst...s.c..s..........s..............ss.....t.......t.....s....c.......t..s...............s..s.....h..........sl....p...........u....u..D...c.....o......G....h......P.h...Ll.lRuPFshlWpRLPsAL-+lG.hcVsDpsRSQGshtV....p..Y........ps....h........s.......-.......u.........t......W......p.c........L..G...u.pc................ss.L..s..u.G..c........Y+l.pV..G...D...L....s..N..R..o.S.l.ph.lDscG+sLopupscslVuVhpAsh............................................................................	0	31	84	141
+6633	PF06805	Lambda_tail_I		Bacteriophage lambda tail assembly protein I	Moxon SJ, Iyer LM, Burroughs AM, Aravind L	anon	Pfam-B_7725 (release 10.0)	Family	This family consists of tail assembly proteins from lambdoid and T1 phages and related prophages, e.g. the tail assembly protein I  (TAPI). Members of this family contain a core ubiquitin fold domain  [1]. The exact function of TAPI is not clear but  it is not incorporated into the mature tail. Gene neighborhoods  reveal that TAPI co-occurs with genes encoding the host-specificity  protein TapJ, and TapK, which contains a JAB metallopeptidase fused  to an NlpC/P60  peptidase. It is proposed that the TAPI protein is  processed by the  peptidase domains of TapK [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.60	0.72	-4.16	15	1136	2012-10-03 10:59:06	2003-08-05 14:19:07	7	4	504	0	59	868	33	71.30	56	35.56	CHANGED	shsplpLtGslt......p+aG+htthsVpThuEulpALusplsuacphh.pth.....atlhhst+N.uccsl.t....ttshsGssI+IlPhstGu	...............................h.................................p..T..u..A..EAIRALu.hQl.PuFRppls..............................-GWYQVRIuG....cDsutstL.ApLp..Es..LssGuVIHIVPRlAGA..................................	0	6	22	42
+6634	PF06806	DUF1233		Putative excisionase (DUF1233)	Moxon SJ	anon	Pfam-B_9240 (release 10.0)	Family	This family consists of several putative phage excisionase proteins of around 80 residues in length.	21.30	21.30	21.40	21.60	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.33	0.72	-4.43	13	472	2009-01-15 18:05:59	2003-08-05 14:24:08	7	1	322	1	19	108	0	65.40	48	88.75	CHANGED	VI.....ls.PscWVsEclLhAlTGLptusIp+ARcpuWhpG+EY++VuPDGpPcss.upshYNhtpIspWIcp....pP	.........l..sscWlsEp.LhshpGl..pttsl.p.+h.Rcp.saMpG+EYKHlu.s-GpPtcp..S.ChYNhccIspWIEpQt..su...............	0	1	5	12
+6635	PF06807	Clp1		Pre-mRNA cleavage complex II protein Clp1	Moxon SJ	anon	Pfam-B_9787 (release 10.0)	Family	This family consists of several pre-mRNA cleavage complex II Clp1 (or HeaB) proteins. Six different protein factors are required in vitro for 3' end formation of mammalian pre-mRNAs by endonucleolytic cleavage and polyadenylation. Clp1 is a subunit of cleavage complex IIA, which is required for cleavage, but not for polyadenylation of pre-mRNA [1].	28.90	28.90	28.90	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.34	0.71	-4.54	16	510	2009-09-11 15:53:51	2003-08-05 14:32:10	9	17	273	2	375	523	8	194.00	21	39.16	CHANGED	GWVpGhGhclLlchlcsasss....hVlVl..sp.E+LhscLppthhsp......................lpllclsKutGVs...........................pRspchR+phR-ppIhpYFh.G.hpssh...hPashsspFsDl................pha+l.....hssssL.lshpspsssh+l......thslhppllAlSh............tpts-sll.......ssslsGFhhlptVDlp+chhslLoPsstp.L.PsshLlhus.lpa.cs	................................................................................................................................GWhps.GhphLhchlpthpss....hllhl.....s....p....c+..hh.s.pLp..p.ph..spp..............................................lp.llt..l.scs..sus.s......................................................................pp.s..pp..h.t...pp.hRc.plp..pYFa....u.........h...p...ts..h....................Phs...ts.s..h..ssl..................................................................p.acl........shssss.....l.....h.....h.p.t....p....s...s..tcl...............................sl.t.p.llulsh................................................................st..t.t.p..s..hh......................p.ssshGashlpsl...............D......h..p..+p...hhpl.LsPh..sh.....L.....s.p...hLl.hst.h......................................................................................	0	144	216	312
+6636	PF06808	DctM		DctM-like transporters	Vella Briffa B, Bateman A	anon	Pfam-B_4075 (release 10.0)	Family	This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers [1]. Note that many family members are hypothetical proteins.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.27	0.70	-5.92	18	7152	2012-10-02 15:12:49	2003-08-05 14:32:48	7	20	1871	0	2023	7864	11933	404.70	26	85.53	CHANGED	lshhhlLhhhuhPluhulhlsul..hhhhhhsss...........sh..lhspphhs.......u....lsshsLhAlPhFlLhGslhppsGhuccllchssullG+h+GGhuhsslhuuslhuulSGSulAsssslGuhhlPhM++pGYssshAuAlhAuuushu.llPPshshllauh..............hsslSluslFhAGllPGll....................................hhlslhhsshhhAp.+psh.s............................tscsphtphhpuhhpuh...........................................uLhlsllllhulhhGh.....aTsTEAuuhulshu..Lhlullh..........h+chshcclhcs........Lhpsucss....usVhhllAuuulhuahlohsslshtlushlhulss..................st..hhhLllsslhhl..llGhhl-ssAsllIlsPlhhPlhtphGlDP................lahGlhllhshslGhhoPPVGhslaluuuIu..............p.sshhpsh+tllPalhshhssLlLlshlPtl	..................................................................................................................................................................hhhlhh.h..h....hu.h..P.l.u.h...u.l.shsuh.......hh..hh..h..h..ssh..............................................................sh...h.h..spp.h.hs.............................s....h.s.s.h.s...L.h.A....lP..hF...l...L...h.....G.....tl...hppuGlucclls.hs.tt.h.........hG..+....h.......G....G..Lu.....hs....s..l.l...u...shlh...uu.l.S...G....SusAsssuhG....sl....hlP....hM........h.+.t...G.Ystp.h.u.sulh...suuu..sl.G.....l..IP.....PS.hs..h.ll.auh............................hss..hS....l......u......pL........F....h....A..G...l....l...P....G..l..l..................................................................................................................................................h...s..h...s...h...h....h....h....s...h....h....h.....up......+.t...s...h..s.s................................................................................................t....p..h....s....h.....t........p....h......h......p....s.....h...h....p....u....h............................................................................................................................................................................................................s.L...h..l....l....l..l...l..G....u..l....h.s....Gl..........................hT.P...T...E....A.....u....u........l....u......s...h.hu........l.h..l.uh.h................................................................h+p.h..s...h....p..p...l..h.ps.................................................................lhp.s....s.pso........uh.l.....hhl..lus.............us....h.h.u.h....h.h..s..h.t.t.l..s.t.h.l...s....p.h.l.h....s.l.s..s.............................................s.........hh.h.L..l..l..l....l..h....h.l....llG.h..hh.....-h...s....s.....h..hl.l..h.s....P..lh.hP.l.h.....h....p....h......G.......l.D.s........................................................................................la.F..Glhhhh.s....ht.lu.h....l....TP...PlG.hs.l.F.s.s.s.u..lu.....................................p..hpht.p.lh.+.s....l.l.....P..a...h.h...s...h.h.h..s.Lhl.ls.hhPt.....................................................................................................................................................	0	616	1374	1743
+6637	PF06809	NPDC1		Neural proliferation differentiation control-1 protein (NPDC1)	Moxon SJ	anon	Pfam-B_10407 (release 10.0)	Family	This family consists of several neural proliferation differentiation control-1 (NPDC1) proteins. NPDC1 plays a role in the control of neural cell proliferation and differentiation. It has been suggested that NPDC1 may be involved in the development of several secretion glands. This family also contains the C-terminal region of the C. elegans protein CAB-1 (Swiss:Q93249) which is known to interact with AEX-3 [2].	19.20	19.20	19.30	27.80	18.70	19.10	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.26	0.70	-5.65	2	114	2009-01-15 18:05:59	2003-08-05 15:07:05	6	6	79	0	62	116	0	192.70	37	65.07	CHANGED	MATPlPPPSPRHLRLLRLLLSGLlLGAALpGAsAt+PDsssCPGSLDCALKRRA+CPPGAHACGPCLQsFQEDQpGhCVPR..hppsPu.....sphEscI...........shLhQELA..cKEuGHS...s.PL.cstQ+L.EP.ATLGFSthGQtLE.GLPST.GTsoPhPHTSLuS.sSSsPVpMSPLEPpGtpGsGLsLVLILAFClAuuAALuVAuLCWCRLQREIRLTQKADY.ATAKuPsSPusPRISPGDQRLApSAEMYHYQHQRQQMLCLERHKEPPKEL-oASSDEENEDGDFTVYECPGLAPTGEMEVRNPLFDHusLSAPlPuPpS.PsL.	...................................................................................................................................................................................................................................................................................................................................................................................................................................h....hlhshhh.s.ss..h.Al.h....s.lshh....p.h..ppp.+.hstc.sDa...s.shus.s..uss.t.s.t......s.s.G.Dp+LApSApMYHYQHQ+QQhlshE.......ppp...p............sp..t..hp..s.s.pSD--NE-....GDaTVYECPGLAP....T..GEMEV+NPLF..cts........................................................	0	21	27	45
+6638	PF06810	Phage_GP20		Phage minor structural protein GP20	Moxon SJ	anon	Pfam-B_8431 (release 10.0)	Family	This family consists of several phage minor structural protein GP20 sequences of around 180 residues in length. The function of this family is unknown.	31.00	31.00	31.50	31.20	30.40	30.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.97	0.71	-4.78	21	296	2009-01-15 18:05:59	2003-08-05 17:04:18	6	1	261	0	41	246	4	154.40	25	79.64	CHANGED	pcplcplht.cupslt....Ks+hscs...pp....chcsl+pQlspRDpQlp-Lpc.pspDs--Lppcl-cLcppNc....-appclpphphssAlchALschsu+sscslhuhlspDplcLcc-s.lhGL--QIcsL+EScsYLFsppp....pPssuh.......sssssu	.........................................................................................p.hptl.......t.tspplp......K...s...chsph.......pp.......phcslcpp.......lppt-cplccL+c.....p.....stss--L....ppplccLppcs...cp....ttchppchpphph..ssAlchALps..h.....pA...p...s...s...cs.lh.uh...l.D..h-...plclsc-u..lpGL--tlcsLK..cSc..s..aLFtppp...t..pPt.t...........sss............................................	0	23	36	39
+6640	PF06812	ImpA-rel_N	ImpA-rel_N-term; 	ImpA-related N-terminal	Vella Briffa B	anon	Pfam-B_4308 (release 10.0)	Family	This family represents a conserved region located towards the N-terminal end of ImpA and related proteins. ImpA is an inner membrane protein, which has been suggested to be involved with proteins that are exported and associated with colony variations in Actinobacillus actinomycetemcomitans [1]. Note that many family members are hypothetical proteins.	20.60	20.60	21.00	20.60	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.68	0.72	-4.20	143	1962	2009-01-15 18:05:59	2003-08-05 17:19:59	7	7	932	0	298	1333	37	61.00	28	14.43	CHANGED	DWstlpchutpLLtpcoKDL+lssaLspAhh.ctpGhsGlspGlpLLssllppaW.-slaPths	..........sWstlpchuhpLLtspuKDl+lssahhhuht.+ptGhsGhspGlpLLsthlpp.aW.ss.haPp..h.................	0	43	112	200
+6641	PF06813	Nodulin-like		Nodulin-like	Vella Briffa B	anon	Pfam-B_4440 (release 10.0)	Family	This family represents a conserved region within plant nodulin-like proteins.	24.70	24.70	24.80	24.90	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.63	0.70	-5.12	15	586	2012-10-03 03:33:39	2003-08-05 17:21:06	8	13	122	0	360	786	6	218.90	26	41.90	CHANGED	+WhsllAulWlQusuGssasFu.sYSusLKSsLGhsQppLNhLuVApDLGcslGhlSGlssphhPsWsVLhlGAshshlGYGlhWLsVopplstLPhWhlhlhlsluuNSpsWhNTAsLVoCl+NFPtsRGlVlGlLKGYsGLSuAlaTplYpulhss....cssshLLllAllPslVsLsslahlRsp......spssppps-sthFhhhhhlulhlAsYLlshsllpphhshopuhhhshsulhl.lLLlsPLslPl	......................................................Wh.h.hhuuhhlt.hhsG.ss.YhFu........hYSstlK.s.t.h.s......h.sQppls..h.luh....hp.s.lG.t.s..h.G....h.h...u...Ghl......h.p......h......h.............s................s..hhllhlGu.h.hshh.G.Y...h...h...h..........a..L..s..........l...s......t......t...........h......s...................s........h.h.h........h.s...l.h.h.h...l.u..ss..u....t.s..ah...................s.Tu...sll.......osh....pNF..P..p..s..R..G.sslulh+uah.G.L....SuAlhop.lhp.s..hats...........s.s.ss...h...l.L...hlAhh....ss.h.....l....s.l..h.h.h.......h......h.l..+...h.............................ttt....tpt...hh....h......h........h.h...h...slh.hu..h.aLhhh..hht.t.........h.sp...h..h..hhh.h..hhlh.Phhls...................................................................................................	0	73	240	310
+6642	PF06814	Lung_7-TM_R		Lung seven transmembrane receptor	Vella Briffa B	anon	Pfam-B_4367 (release 10.0)	Family	This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.	25.20	25.20	25.20	25.30	25.10	24.90	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.75	0.70	-5.46	15	836	2012-10-03 04:04:29	2003-08-05 17:23:36	8	8	290	0	523	853	12	251.00	26	55.43	CHANGED	lscoGhYslhhh.sp.p......t.psshshpsplsa+NspGYLsAp-hPLh.hYshMslsYslhullWhahhh+ah+DllplQhaIsullhluhsEhsFaah-YthhNspGhs...spshslas.lhuuhKtolstlLlLllShGYGlV+PpLGshhp+lhhlulhhhlhuslhhlhppsuths-tp....thlhhhlPl..uhl.hhhlhWIFpSLsc.ThcpL+h.+RshsKLplYR+Ftsslshullhohsahhhp.lhh...pthsshpptW+.tWlhs.saW.cllshslLllIshLWRPopNs.	......................................................s.Y.lh..h..h.................................s..h....p...h.ph.p.h....p.h...ps........s.....h..u......a.Lsus....phP.h.............hYhh..hslhYh...lh.u.h................hWhh.h.h........h..p...h..h..p.............s......l..h.plphh.h...su...l...lh...hthlphh...hh.hh.pa...p..hs..............p.pG............................sps....hhlhh.lhphh+tshhhhllllluhGauh.lK.s..h......L...u.......p........t.............p....+...l.hh.lsh....h.lhusl....h.........l..........l...........h..........................s......................s..s.t...................................h.lhhhlsl............shh...hh....hh.W..............h....p..p.............L...pp...oh.p...p.h....+..................h....tp...p............hs..KLp.....la...............R+.ah.h.ll.h.hlh.....h..ohh...hhhh..h......................h...pWp....W.h....shh.ph.hhhhh....hh.hhh......hha..RPstss.............................................................................................................................	0	155	276	408
+6643	PF06815	RVT_connect	rvt_connect;	Reverse transcriptase connection domain	Bateman A	anon	Bateman A	Domain	This domain is known as the connection domain. This domain lies between the thumb and palm domains [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.26	0.72	-4.14	47	20194	2009-01-15 18:05:59	2003-08-05 17:58:29	8	56	614	372	0	19630	0	90.20	85	13.88	CHANGED	sYYcPpKsLhAclpKhGpsQWsYplhQ..pp+..sLKsGKau+t+ssHsNshcpLApslpKIucEuIVIWG+lP.pFcLPlp+Es..WEpWW.s-YWQsoWIP-hEFlsT	..............................................................VYYDPSKDL.....IAEIQKQGQGQWTYQIYQ...EPFK...NLKT.GKYARhRuAHTNDVKQLTEAVQKIuTESIVIWGK.TP.KF+LPIQKET..WE.......................................	2	0	0	0
+6644	PF06816	NOD	NOD; NOD1; 	NOTCH protein	Guo J, Studholme DJ	anon	Guo J	Family	NOTCH  signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be  elucidated.	19.40	19.40	19.60	19.40	19.00	19.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.64	0.72	-4.88	26	289	2009-09-11 05:54:01	2003-08-06 11:46:38	8	241	92	8	132	222	0	56.10	43	2.77	CHANGED	PtpLApGsLlllVh.lsP-ph..ppsussFLRcLSplL+TsVph+pDspGpsMlaPahGp	....PtpLApGsLVlVVL.hsP-pL..hpsut.sFLRp.LSplL+Tslph+pDupGp.MlaPYaG......	0	23	35	81
+6645	PF06817	RVT_thumb	rvt_thumb;	Reverse transcriptase thumb domain	Bateman A	anon	Bateman A	Domain	This domain is known as the thumb domain. It is composed of a four helix bundle [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.30	0.72	-4.40	41	66982	2009-01-15 18:05:59	2003-08-06 12:13:26	9	77	671	372	39	66594	2	64.00	90	13.78	CHANGED	KWplQpIpLPcp-..phTVNDIQKLVGcLNWAu.Ql.YsG.I+sKpLCKLlRG.sKsLs-hVthTcEAchElpcN+	.......................KWTVQPIhLPEKD......SW.TVNDIQKLVGKLNWA......S.QI..YsG..IK..V+..QLCKLLRG.sK.ALTEVlP.LTcEAELELAEN.................	0	13	13	14
+6646	PF06818	Fez1		Fez1	Vella Briffa B	anon	Pfam-B_4593 (release 10.0)	Family	This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5 [1]. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth [2]. Note that some family members contain more than one copy of this region.	26.40	26.40	26.90	27.60	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.61	0.71	-4.30	8	300	2009-01-15 18:05:59	2003-08-06 14:17:55	10	3	66	0	170	232	1	152.80	38	31.58	CHANGED	TKWEVCQKSGEISLLKQQLKESQAELuQKuuEIluLRuQLREuRupLpspEtphpcLc-uh+T+sLELElCEsELQR++sEAELLREKss+l-tElscL+-Ahuup..........t..s..h...............................ESDE...AKupcts......................tsshpsLRppl-RLRAELptERp+tEcQusuFEcER+lWQEEKEKVIRYQKQLQpsYlpMYpRNppLE+cLpp	...............................................................................................................................opWEVC...QKuGE..ISLLKQQL+-uQsElspKhuElluL+s..p.L+..-sRuphptp-tph.tL....pt.uh..........ps.ct.phc..tptph..................................p.......................................................................................................................tpt...st..t............................................................................................h.th...p.tphppLpsEL....ERpttcp.t.sFptERhsWptEK-+VlpYQ+pL.Q.sYlpMYpRNptLEptlp.......................................................	0	17	33	82
+6647	PF06819	Arc_PepC		Archaeal Peptidase A24 C-terminal Domain	Yeats C	anon	Yeats C	Domain	This region is of unknown function but is found in some archaeal Pfam:PF01478. It is predicted to be of mixed alpha/beta secondary structure by JPred.	21.20	21.20	21.20	62.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.18	0.72	-4.14	10	35	2009-01-15 18:05:59	2003-08-06 14:21:48	6	2	35	0	27	37	0	111.70	35	30.52	CHANGED	Vh.phllhlhplpLIhtllpALTsttls.ccKpV-ELKEGDILt-hIhlpssG.Vhh-pushhcRhKphLcsEpscslp....ccllsssuEGLocEpIEcLKKLssEGKlpsEhpV	.hl..phhlhlhtlpLl.hllhuLpsttls.-c+pl-ELKEGDILt-hIhhcsst.Vhh-psshhcRlKphlpstphps......tchllhssuEGLocEsIEhLK+LhpEGKlpsch.V.....	0	4	7	18
+6648	PF06820	Phage_fiber_C	Tail_fib_C-term; 	Putative prophage tail fibre C-terminus	Vella Briffa B	anon	Pfam-B_5030 (release 10.0)	Family	This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.	25.00	25.00	26.60	25.90	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.07	0.72	-3.84	2	1275	2009-01-15 18:05:59	2003-08-06 14:42:52	7	14	118	0	2	871	0	62.30	64	34.03	CHANGED	hphRLGPAsIlEosppGhhPtpD.tlITtlshL.stDppplQshhp.LQlhhuDG.WpsltGhc	.........hphRL.GPAsIlEospNGhhP-pD.tlITtlshL.stDtpQlQslhR.LQlhhuDGsWpsltGhc.................	0	0	0	2
+6649	PF06821	Ser_hydrolase	DUF1234;	Serine hydrolase	Vella Briffa B, Eberhardt R	anon	Pfam-B_4941 (release 10.0)	Domain	Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile [1].\	      This family has an alpha-beta hydrolase fold [2,3]. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family [3].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.11	0.71	-4.66	24	1243	2012-10-03 11:45:05	2003-08-06 14:56:12	8	3	948	5	341	1631	220	168.30	26	89.49	CHANGED	hLIVPGapsSus.sHWQoaWpcphssu.pRVcQt-W...ppPshs-WlstLppslsttsts.......sllVAHSLGClsss+hs.....hpttc..pVtGALLVAPsDs.............p...tstthtsFuslPpp.LsFPo.....llVAScNDPasshppApphApsWGuthlslGpuGHINs-SGaGsWPpGhhlLsp	......................................................................................................................................hlIl.G..h..p..u..s..ss...sH..W...sh.h....pc.p.l..st....t.......h........c...V.....p...........h.......sa...........pp.P...s....h....s....p........W.....h.........t..t....lp...p.......tl..s....t...t....p...p.s..........s.hlVuHSLGslssl+ah..............ttpp...pl.t.G.h.l..LVA.s.h.c..t............................................................t.....t..s.....h.h..p..s.h...s.....s....h..s...p...p..t..h..s.h.ss....................hl.....l..u.S.cNDsa.ss..h..p.p.u.p....pl..A.p.sh..s.....u.p..hhtl..spuG.Hhss.psGassastshth...p..........................................................................................................................................	2	59	167	254
+6650	PF06822	DUF1235		Protein of unknown function (DUF1235)	Vella Briffa B	anon	Pfam-B_4988 (release 10.0)	Family	This family contains a number of viral proteins of unknown function.	25.00	25.00	39.30	39.20	20.70	18.30	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.75	0.70	-5.42	11	73	2009-01-15 18:05:59	2003-08-06 15:05:26	7	1	38	0	0	65	0	226.30	54	91.54	CHANGED	hIPaFs.s+I......+splhcLss.s.......hhpYht..HsphIlpEIc+al...s-plhssshlslphacpppshp...pspspshS+lllClpuAp+GGslllpsphss.p+pllp.sssphllLSPLucYsVopVp+GshlllslclsIPSMc....lhhhstpsl+asNslplLhPhpts-lsFsl+plhDhpsscllCEQllINpcWYTlls..sssp+lhlPSh..ChGpoh..chsaspss.cc-hlpp..llshpsPF-.hlhPp+sIYsuh.lt...E+llYG+l	...............hhPhFshSKI......pshl...sNss.......pphYhcsEHp+IIocEIsRpM...DEsVLLTN.ILSVEVVNcNEMY....HLIPHRLSpIILCISSl..GGCVISIDNDlN.sKNILTFPIDHAVIISPLuchsV..VsKGsshllllcsDIPShR....llsoh.sssIhYsNsLsLls.lshS..VFlIRploDhh.s++lC-QIFhNs+WYolIs....hssKpasIPSs..ClGhos...spYlssoh-pDhlh+..lhNl-hPFD.hla.+hpsYsSlsl+...EpILYG+I.	0	0	0	0
+6651	PF06823	DUF1236		Protein of unknown function (DUF1236)	Vella Briffa B	anon	Pfam-B_5056 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function. Some family members contain more than one copy of the region represented by this family.	20.60	20.60	20.60	21.70	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.19	0.72	-4.25	57	317	2009-01-15 18:05:59	2003-08-06 15:12:02	7	9	104	0	164	322	7	64.40	33	37.89	CHANGED	YVppp.l.....tshsh..ptclsVGsslPcs..Vplpsl..Psp.....s...sYpYslVN-.chVlV-PpoRcIVpllc	..............................hlppp.s...shth...phclsVGsslPcs...Vp..lpsl...Psp......s......sYpYslVs-.chVlV-PpT+clVpVlp...	0	22	74	102
+6652	PF06824	DUF1237		Protein of unknown function (DUF1237)	Vella Briffa B	anon	Pfam-B_4981 (release 10.0)	Domain	This family contains a number of hypothetical proteins of about 450 residues in length. Their function is unknown, and most are bacterial. However, structurally this family is part of the 6 hairpin glycosidase superfamily, suggesting a glycosyl hydrolase function.	20.10	20.10	20.70	20.60	19.30	19.70	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.29	0.70	-5.87	51	1064	2012-10-03 02:33:51	2003-08-06 15:25:53	6	9	860	15	263	760	58	389.20	45	85.81	CHANGED	D.-LupLF.cNsaPNTL.........DTTlca...............................................ttspspTFVlTGDIsAhWLRDSosQltsYlslsccDt...........pLppLltGsIspQschllhsPYsNAFpss.......sstput.t.sDps.........p..t................s.hVaEpKYElDSLsh.lpLutpaacpT.G-s........shhssp.WhpAlcpllclhcpppp.................................tpsh.ssYsFpRpTshuo-TLshsGhGsPls..TGLlpSuFRPSDDAolasahIP.uNhahsstLcphucl...ht.tthtsc...................LuppspphupclcpuIpcaGllp..........H.scaGclaAaEVDGaGuthhMDDANlPSLLuLP.hLGals.hcDs........................................................................................lYpNTR+hlLSpp.NPYahcGpthcGIGGPHlGhphsWPMSlllpuhTo.............sD-pEItpsLphlhsosuGhGlhHEShcssss..pcaTRsWFAWANohFuchllc	...........................................t..chsphF.ppsassTL.........-TTVch..................................................c-ssTFVlTGD.IPAMWLRDSoAQl.pPYL......hlAccDs....................pLpphItGllpRQhphlhhDPYANAFN.s.........sht....G.........ap..s.......DcT..............chs..........................s.hlWERKYElDSLCYPlpLAYhhW+pT...Gco......s.Fsp.....p..ahpAhcpILclaphEQc......................................t...t.p.SPYpF...R.....sTs.....p.......tpDTLspsGhGs....sssh..TG.MsWSuFRPSDDACpYuYLlP.SNhFAVVsLthlpEI....hps.lt....h.p.c..p.....................................lstcspcLtcEIppGIcpauhsp.............p..sph.......tcl.YAaEVDGhGs..t..l.MDDu.N.VP.SLL.uhP.YLGass..h-D.........................................................................................l..YQsTR+hlLSpc.......NPYaap..Gp.....hupGIGSsH....................os......h...pYl.WPluLuhp...GhTo.............pD....csEhcphLchLlsoDu.GTGhMHESFc..sssP.....spaTRpW.................FuWANhhFsELllc....................................................................................	2	95	173	226
+6653	PF06825	HSBP1		Heat shock factor binding protein 1	Wood V, Studholme D	anon	Pfam-B_20266 (release 10.0)	Family	Heat shock factor binding protein 1 (HSBP1) appears to be a negative regulator of the heat shock response [1].	24.00	24.00	24.00	24.00	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.72	0.72	-4.39	20	305	2009-01-15 18:05:59	2003-08-06 17:00:52	7	4	201	2	193	288	2	50.70	47	56.10	CHANGED	sp-LosaVpsLLpQhQs+FpsMScpIls+ID-M.......................upRID-LEpols-L..hspsGs-	..........h.p-LTshVpsLLpQhQs+FQsMS-p...IlsR......lD-M.......................usRID-LE+sIsDLhspsGh..........	0	60	94	143
+6654	PF06826	Asp-Al_Ex		Predicted Permease Membrane Region	Yeats C	anon	Yeats C	Family	This family represents five transmembrane helices that are normally found flanking (five either side) a pair of Pfam:PF02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the Pfam:PF02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter ([1]). In  conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalysed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.21	0.71	-4.76	34	4439	2012-10-02 17:06:44	2003-08-06 17:46:47	7	8	1308	0	585	2491	77	168.70	31	61.72	CHANGED	slslslslGhhlGplph......hulsLGsusGsLlsuLllGpht........hshshsthlpslGLslFlhslGlpuGssFhsulpps.Glphhhhulllsllshllshllu+..lhchshshssGhhuGuhTsosulusus-t.sp.shss............luYussYshGhlhhllhs.tllhh	....................lhlslslGlhlGpl.pl..........tulpLGhuhG.....sL.....hsulllGp....h.....t..h.hh..................hs.sh..p...h.lpp...hGlhLFlhsVGlpuGs.sFhs.s.ltps..G....h....phh.hhulllsh.lshlls.hll.u...+...lh........c....h....s....h....s..hhhG..hhuGuh.Tss.PuLuhusst........sp...s...s.hsu................................................................luYAhsYsluhlhhllsspllh.h.................................	0	157	335	485
+6655	PF06827	zf-FPG_IleRS		Zinc finger found in FPG and IleRS	Bateman A	anon	Bateman A	Domain	This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.82	0.72	-4.26	143	6847	2012-10-03 10:42:43	2003-08-06 17:58:27	9	22	3732	62	1464	4839	1582	29.50	34	5.63	CHANGED	uphC.R..Chph.hpchth..stctshhCs+Cpph	..........Gc.CtR..Ct..s.....h..lpclsh.....ss+sshhCscCQp.....	0	441	915	1228
+6658	PF06830	Root_cap		Root cap	Vella Briffa B	anon	Pfam-B_5867 (release 10.0)	Family	The cells at the periphery of the root cap are continuously sloughed off from the root into the mucilage, and are thought to be programmed to die [1].This family represents a conserved region approximately 60 residues in length within plant root cap proteins, which may be involved in the process.	20.80	20.80	22.50	22.40	18.60	18.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.73	0.72	-4.13	18	153	2009-09-10 23:47:36	2003-08-07 11:46:05	6	5	23	0	81	151	0	55.20	54	17.43	CHANGED	uFKFasLSscVcGVLGQTYRsDYVNp.lcluusMPVMGGsccYtTSuLFusDCsVuRF	......sFKFa.sL..ospVcGVLGQTYRssY.ls....lcluss...MPlM.GGtscYts.SsLFusDCtVuRF......	0	9	43	70
+6659	PF06831	H2TH		Formamidopyrimidine-DNA glycosylase H2TH domain	Bateman A	anon	Prosite	Domain	Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain [1].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.00	0.72	-4.23	19	5357	2012-10-02 21:21:44	2003-08-07 11:51:56	9	25	3675	70	1277	3734	2235	91.20	32	32.59	CHANGED	LGP-PL.........p..sh...............t.htptltc...p....+.....+slKshLLDQplluGlGNIYsDEsLFtutlcPpphAssLstpchphlhpslpplLpcAlphstsshph.s	...............................................LGP-PL.............sssh.ss.......................p.h..l..tp.t.l.tp......+......p.................ps.I..K.shLL..DQ.p.ll.....u...GlGNI.......YssEsLap...Atlp.Pp+.....ussL......o......t......t............c......h......p......t......LhpsltplltpulptGGoo....th......................................	0	400	799	1061
+6660	PF06832	BiPBP_C		Penicillin-Binding Protein C-terminus Family	Yeats C	anon	Yeats C	Family	This conserved region of approximately 90 residues is found in a sub-group of bacterial Penicillin-Binding Proteins (PBPs). A variable length loop region separates this region from the transpeptidase unit (Pfam:PF00905). It is predicted by PROF to be an all beta fold.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.98	0.72	-4.06	111	1158	2012-10-03 16:25:20	2003-08-07 12:26:00	7	11	1137	0	250	947	46	88.70	30	12.10	CHANGED	ststts..tts.ss.pIhhPscGuhltls.s..........t........ttplslcstuu.ps.........hhWhl.......sGp.l.spstptcphthts....tsGhapLol..lDssGpssp..lph	..............................ss.s.....ssp.hsLplsusp..-.Gu.hlphhsst.........s................pssLs.lpssGG.su........chaWaL...................NGcsl........s..pp.....s.c.slshph....tptGc..a....pLhV..hD-sGphss..Vph...............	0	69	147	199
+6661	PF06833	MdcE		Malonate decarboxylase gamma subunit (MdcE)	Moxon SJ	anon	Pfam-B_10907 (release 10.0)	Family	This family consists of several bacterial malonate decarboxylase gamma subunit proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcD and E together probably function as malonyl-S-ACP decarboxylase [1].  	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.39	0.70	-5.16	9	323	2012-10-02 13:07:06	2003-08-07 12:47:24	6	2	311	0	94	1349	480	245.50	37	82.37	CHANGED	shhsuLhss...tpuhsssstVlcGphst.sst.lsVlussN.......putlGl.EuhuLAtsV.-sl....ppts+pPIlsllDssSQthuRR-EhLGIppsLAthupuhshARhuGHslIGLlhGcAhSGAFLAaGhtAscLlALs..Gs.l+sMshsuhARVTphoVEtLcsLAtosPshA.sl-NYsphGhlpthhssppsps.uss.hs.lpp..tt..tDt........pRhsGtpRtupphspclhccsh	.....................................................................hhsuL...h.st.......hpuh..s.s..ss...p....lh..sG..p..h..st...ss+hluVV...ss...sss.h..................RstpGEVG..L.......E..G..as..L..A.......ps..V..-s.l....stcpss..KRPIlsllDVsSQAYGRREEhLGIapALAsuucuYApA.Rh.AG..H..PlIGLlsG+Ah...SG...A.F...L...A...H...G...h.Q...AsRLlALss..Gshl+sMuKtuA.A......R.V..........T.h..R.........o..........V..........-.......pL......E.....p....L....Ap.o.lPshAYs.lcNY........sp.L........GhlpplLs..s......s..s.c.s.s.s.s..st..l.s..h.lppslsp.shtDh................pchtutpRtupthspchhpt.....................................................................................	0	12	40	65
+6662	PF06834	TraU		TraU protein	Moxon SJ	anon	Pfam-B_10708 (release 10.0)	Family	This family consists of several bacterial TraU proteins. TraU appears to be more essential to conjugal DNA transfer than to assembly of pilus filaments [1].	25.00	25.00	29.50	25.80	23.40	24.10	hmmbuild  --amino -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.02	0.70	-5.29	58	720	2009-01-15 18:05:59	2003-08-07 12:50:46	6	3	485	0	138	610	39	276.00	32	88.84	CHANGED	uphlss..hsssshsCl.shplsGhsh.....................hhhC.ss.sshh+sulpluaapPstlVsshpssts.Phltstplshu.....................shsp.tttsssppspssh....sFhpschhuaPhhhhh.shlss...........................................................................................................hsC.ssssh....halSplDsh.Wpssh..thl.....PEAll.Gt.htl..uussuss...................saGslYPhsGh.sspssshpuuullupRhsshlp...R..pshlat..shus................................uhshh..hstPlhc...pppa+aQhlhPhssss......Ctsasposhh.t...spphssss.ssauahlWRhhsCCtt	......................u.thhsslsshthsCl.shpluulph....................hhhC..ss...s.hhh+hultluaapP.tllsshpsPGs.s.lt..hthhshs.............................tstt.s.ssptppcpssh....sFhpschataPh.h.h..hl.shhss.............................................................................................................................hsC.tsush...........lhYLSElDPh.Wpss...h....sthlt............PEAllhus..hs.uAssu-s....................................................has.ts.Gs..hYPhsGa..s.....spssshpuusllupRhsthlp....R...Qshlhp..shut.s......................................uhCh....hssPlh.....+ppa+aQhltPhssss..............................C.pshs.c...oshhht.........sps.s.....s...s.....t....psauahlWRhhsCC...........................................................	0	30	71	111
+6663	PF06835	LptC	DUF1239;	Lipopolysaccharide-assembly, LptC-related	Moxon SJ	anon	Pfam-B_11065 (release 10.0)	Family	This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.79	0.71	-4.87	64	2204	2012-10-01 21:43:16	2003-08-07 12:52:59	8	16	2061	1	556	1696	1443	166.70	19	80.55	CHANGED	hllhhllsuhh.hhhhptpsst.........sthpspps-ahspshpsppaspsGp.hpaclpuschc+as.ssst.........shhspPslhhapssp....................WplpuppuplsptsphlpLhssVtlpphtspsp..............hpplpTsphplphpsphhpo-psVplpsssh..thsGhGhcuslcspphpLhspV+...sp.a-	..........................................................................................h..hhh.lhsh...hhh...tt.................ptpp.ssh...h.......pp..hph.h........h.s....p.Gt...h.....pap.lhu.p...c.h.p.hhs...sps.h..........sh.h.p.p...P...h...h..pha.spsp..............................ssh.p.lpAccu..p.lss.....s.p..hlh...L.hu.s.Vplpsh...ttp..............................htplpTc.p...hplshp...s..p...p.l..p..o...-..c......Vp..l..h...s...ss..h......ph......s.G.h.t.hc..ssh..ps..p.phplh.p.pVps..............................................................................................	1	161	349	464
+6664	PF06836	DUF1240		Protein of unknown function (DUF1240)	Moxon SJ	anon	Pfam-B_11130 (release 10.0)	Family	This family consists of a number of hypothetical putative membrane proteins which seem to be specific to Yersinia pestis. The function of this family is unknown.	22.00	22.00	22.00	22.00	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.17	0.72	-3.77	16	192	2009-01-15 18:05:59	2003-08-07 12:54:50	7	2	47	0	51	115	0	92.90	45	71.30	CHANGED	DcIpFSusVhIhhFSsPLlhYhhshulashIpN+hPKapcphs+hLshlAlhShllSFPlSFYVcYKLKupuYlVCsRISWMSPNsYVKDlpLCc	.............DhIhFShtlsl.hlhusPLLhYh.hhuh.ahhI........hN+.........s........KhN...s.hlsphLs...hlAl.luhllSh.hShYlsYpL+ptGYlsC.sRh...S.WMS..P....NpYVKDlpLCc............	1	0	22	26
+6665	PF06837	Fijivirus_P9-2		Fijivirus P9-2 protein	Moxon SJ	anon	Pfam-B_11357 (release 10.0)	Family	This family consists of several Fijivirus specific P9-2 proteins from Rice black streaked dwarf virus (RBSDV) and Fiji disease virus. The function of this family is unknown.	25.00	25.00	30.60	189.80	24.20	22.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.39	0.70	-5.20	3	20	2009-01-15 18:05:59	2003-08-07 12:58:00	6	1	6	0	0	20	0	206.50	68	99.93	CHANGED	MDs.ppSV.hDoYTFpCPFEL...AKIclcuhpNsMp-VoNFsslF-hshSDSElDD+VDsLElcVEcsssPLl+RtYGKVG+IlahIlSFLFFGIFKLVLKhFYHLF+CVhCNPLoRsllSIIFTIlFYhhLhVsIYLLaaFFGDsIIpslNsLNp.cSsNFlNSTQshsuKVEEpVtKIIQsspLlFuppDpNslQpN-KussVsNGsTsNaTLFN	MNP.QSSVNlDTYTFNCPFEL...AKIQIEShKPIMQDFSNFD-IFERsLSDSEIDDRVEpLElDVEuKVDPlVRR+YGKlGHIIlMIISFVFFGIFKLTLKMFYHLFRCVCCNPLIRGIhSIlFTILFYhLlhVsIYhVYaFFGDQI.tsYNoLsphcsSshINSTp.....VEEKVcNIIH-GSLFFGohDpsTGplpElEpQVsNGGTVNYTLFN.	0	0	0	0
+6666	PF06838	Met_gamma_lyase	Alum_res;	Methionine gamma-lyase 	Vella Briffa B, Haft D	anon	Pfam-B_5307 (release 10.0)	Family	This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	405	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.14	0.70	-6.17	14	999	2012-10-02 18:26:03	2003-08-07 13:00:36	6	5	922	20	186	1314	419	385.50	52	96.17	CHANGED	h.plhcpAEtslhshFcplDchschNQh+VLpAFpccRlS-pHFssoTGYGYDDlGRDTL-pVYAcVFGAEuALVRPQhVSGTHAIusALFGlLRPGDELLhlsGpPYDTLEEVIGl+Gp.stGSL+-FGIsY+pVsLptpGclDapslppulp..spTKlltIQRSpGYuhRPShoIs-ItchIphVKplNPslIlFVDNCYGEFlEppEPscVGADLhAGSLIKNPGGGIApsGGYlAGKp-hlEtuuYRLTuPGIGpEsGAohsphp.haQGLFLAPHVVuEAlKGAhhsAtlh-clGasspPpasspRoDlIQulpFsscEKhIAFCpuIQtuSPIsualpP.PusMPGYEDcVIMAAGTFIQGSSIELSADGPlRtPYhuYlQGGLTasHVKlAlhtAlsplh	....................................................................................................h.tlhpclEppltshaccl-ch.s.hNQhKVLpAFpcp+lo..-.pcht.s.o.T.G.YG.Ys...Dh...G...R...Dp....LEcl...YAp..lFtu.E.s.AL.VRPQllSGTHAIuhALhulL...RP...GDELlh...lT...G.pPYD.TL..pEVIG.l............p.Gp..uh....GS.L.t.E.aG.lsYcp..lsLp..-t..Gpl.Dh-sltpsl.p..p.p.T.KllsIQRS+GYu.pRsShsls.............cIcchIs..hl..K.plp...P....s.lllFVDNCYGE.FlEppEPscl.G.AD....LhAGSLIKNP.GG.Gl.A..s.GG.Y.I.s..G.+.c.-.Ll.Et.s...u..Y.RLTuPGIGpEsG..A..oL.s..s.h..p..p..h..YQ........Gh....FLAP....+.V...VupAlKGAlFs..A..t..h..hE.chGh.p.ss...Ppast...R.oDlIQsVpFpstEphIuFCpuIQtuSPlsuahsP.PshMPGYED-VIMAAGTFIQGSSIELSADGPIRsPYtsYlQG.GLTYpHsKlAlhpAlpphh...................................................................................................................	0	77	135	161
+6667	PF06839	zf-GRF		GRF zinc finger	Bateman A	anon	Bateman A	Domain	This presumed zinc binding domain is found in a variety of DNA-binding proteins.  It seems likely that this domain is involved in nucleic acid binding.  It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to Pfam:PF01396.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.49	0.72	-4.03	14	1335	2012-10-03 10:42:43	2003-08-07 13:01:28	7	90	280	0	771	1259	16	45.30	32	10.05	CHANGED	shCs.CG.phshhhssp.sG.NpGRpFYpCPhsc......tCsFFpWsDps	............hCp.C....u..p..s..h..h.hs.sp.p.s..u..sNp....GRp.........FasC..stspt..................ttC..s.FFpWt-........................	0	155	290	523
+6668	PF06840	DUF1241		Protein of unknown function (DUF1241)	Moxon SJ	anon	Pfam-B_11380 (release 10.0)	Family	This family consists of several programmed cell death 10 protein (PDCD10 or TFAR15) sequences. The function of this family is unknown.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.92	0.71	-4.97	6	159	2009-01-15 18:05:59	2003-08-07 13:03:01	6	3	106	19	95	131	2	130.10	42	55.91	CHANGED	hs--ss.lsuh........sL.llhcPlhscLE+.cchs.....AsQpL+sAhhKuEppsPGhohDllssIlc+t..-lsVNhsEolLRhtutss-....EYphsRpEscFpELs+KAtsLKpILS+IPDEIsDR+sFLETIK-IASAIKcLLDAVNpVachlPs....hosKpAlEc	.............s.......hsSh........sL.slhhPlFscLE+..hshu......AAQoLRuAhhKAEppsPGlTpDllhpIlc+t..slplNhsEolL.Rhtusts-....Eahl.pRsE.tFQ-Lsc+uhuLKpILS+IPDEIsDRhpFLpTIK-IASAIKcLLDsVNplhp...hh.......ps+pAlEp.................	0	34	42	70
+6669	PF06841	Phage_T4_gp19	T4_Gp19; 	T4-like virus tail tube protein gp19	Moxon SJ	anon	Pfam-B_11507 (release 10.0)	Family	This family consists of several tail tube protein gp19 sequences from the T4-like viruses [1,2].  This famiyl also contains bacterial members which suggest lateral transfer of genes.	19.20	19.20	19.30	19.20	18.70	19.10	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.57	0.71	-4.53	97	689	2009-01-15 18:05:59	2003-08-07 13:07:47	7	4	303	0	272	645	2092	139.90	19	81.40	CHANGED	ssFpFtVp.h..............ssht..................suFpcloGLshchpshpa+c..Guss......hhh....+hPGthcassloL+RGls...p......spp..lhpWhp......pshpsth........................++slslpLhscsu.p...................l.h.sWplhpAaPs+h...........su.sslsA....susplAlEolcLsa-thp	...........................................................h.F.lp.h..................ss.........................hth..p.pssuhp......hp......hps.hphtp...Gsts............hhh......phs.G...p.hp.a.s.s.l.oLcpslsp........spt.hh.pWhp.............pstssth..p.....................................ccshslpl....h.spss..p.........................................sl.h..paplhsuaP.sch...........ss.ssLsu....sssp.l.shpslplsacth................	1	94	202	251
+6670	PF06842	DUF1242		Protein of unknown function (DUF1242)	Moxon SJ	anon	Pfam-B_11544 (release 10.0)	Family	This family consists of a number of eukaryotic proteins of around 72 residues in length. The function of this family is unknown.	25.00	25.00	25.60	28.20	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.70	0.72	-4.45	32	317	2009-01-15 18:05:59	2003-08-07 13:10:49	7	9	230	0	201	288	0	35.50	49	38.14	CHANGED	LLhVlLLlICTCoYl+thhPullDp....s+.sGhhGhFW	.....LLsVlLLlICTCsYl+phhPullDp..............s+.sGhhGlFW..........	0	63	105	161
+6672	PF06844	DUF1244		Protein of unknown function (DUF1244)	Moxon SJ	anon	Pfam-B_11743 (release 10.0)	Family	This family consists of several short bacterial proteins of around 100 residues in length. The function of this family is unknown.	21.20	21.20	22.70	21.80	20.00	18.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.31	0.72	-4.15	69	402	2009-01-15 18:05:59	2003-08-07 13:15:05	6	6	397	4	128	343	734	67.20	61	61.82	CHANGED	VQNIDLMNLAGFCRNCLS+WYp-AAp-pGlplsc-pAREhlYGMPYs-WKupaQscAosEQhAuFcts	...........VQNIDLMsLAGFCRNCLS+WYpsAA-cpG.l-lshD-AREtVYGMPYsEWKupaQscAosEQhAAFct.p............................	0	37	73	98
+6675	PF06847	Arc_PepC_II		Archaeal Peptidase A24 C-terminus Type II	Yeats C	anon	Yeats C	Domain	This region is of unknown function but is found in some archaeal Pfam:PF01478. It is predicted to be of mixed alpha/beta secondary structure by Prof.	26.20	26.20	28.10	26.90	26.00	19.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.23	0.72	-3.56	21	99	2009-01-15 18:05:59	2003-08-07 13:22:34	6	2	90	2	63	95	11	90.10	24	34.07	CHANGED	hhKchlhhhhGh+hclp................p....hc.cpthhLsptp-.tt.h...hh.hpsh.psssphptplpcatcc....cp..lWVTPGlPFllsIshGalluhlhGDh.l	.............................................................................h......h.h.u..hpht.................t....ht.t.hh.hhptct......................h...h.htshtp.sspphpcthpphscc........cp..lWVoPGlPallslhlGallullhGDhh.....	0	15	39	53
+6676	PF06848	Disaggr_repeat		Disaggregatase related repeat	Moxon SJ, Mistry J, Adindla S	anon	Pfam-B_11958 (release 10.0)	Repeat	This family consists of several repeats which seem to be specific to the Methanosarcina archaea species and are often found in multiple copies in disaggregatase proteins. Members of this family are also found in single copies in several hypothetical proteins.  This repeat is also known as DNRLRE repeat and is predicted form a mainly beta-strand structure with two alpha-helices [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  It is found in some cell surface proteins. 	27.60	27.60	28.30	27.70	27.30	27.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.13	0.71	-4.86	16	49	2009-01-15 18:05:59	2003-08-07 13:26:16	6	15	13	0	31	50	4	168.90	48	32.12	CHANGED	DNRLREuSP-sVap-osaIDlGuhsssG+YRDlhhF-LScYsssspIss....ATLSLYWYYPsspsRPEDTVlElYRPAuuWNPsYVSWNpRDcslsWpNsGGDWYDKNGVLQGSTPYATlTlKGSsLPDNRYYELDVTDLVKEYVSGKYENTGFLIKARoEssNYIAFYSs-sssEsQcPKLsl	....................DNRLREuSP-sVap.sosaIDVGuhsss.+Y...RDlhhFDLSpas..s.ssclss....AsLSLYWYYPs..up..sRscDTllElYRPAou.....WsssYVoWNp+DpslAWpNsGGDWYD+sGlhQGsTPYAolTl+GSpLP.D.N+YYElDVT-LVpEYlSG+YEN...TGFLIKuRsE.ss.NYIA........FYSs-sssEsQhP+Lpl...............................................................................	0	13	14	14
+6677	PF06849	DUF1246		Protein of unknown function (DUF1246)	Vella Briffa B	anon	Pfam-B_5448 (release 10.0)	Family	This family represents the N-terminus of a number of hypothetical archaeal proteins of unknown function.	25.00	25.00	113.00	112.20	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.55	0.71	-4.35	43	187	2009-01-15 18:05:59	2003-08-07 13:58:34	7	1	109	19	117	182	116	124.90	42	35.14	CHANGED	IuTluSHSALpIhcGAKcEGF+TlslCpcuR.-phYpcFs.............hsD-hlll-cap-lh..chtpcLhcpNuIllPHuSalsYlGh-plEs.htVPhFGNRplLRWEs-Rstcpp...LLccAGI+hP+tac	.IuTluSHSALpIhcGAKcEGFcTlslsp.+sR.cthYpcF..............hhD-hlll-pas-ll..chtccLhcpNuIllPptSFlsYl....Gh-plEs.hpVPhFGNRplLRWE.-Rstcpp...LLccAGlchP+ha...	0	29	58	87
+6678	PF06850	PHB_depo_C	PHB_depo_C-term; 	PHB de-polymerase C-terminus	Vella Briffa B	anon	Pfam-B_5697 (release 10.0)	Family	This family represents the C-terminus of bacterial poly(3-hydroxybutyrate) (PHB) de-polymerase. This degrades PHB granules to oligomers and monomers of 3-hydroxy-butyric acid.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.16	0.71	-5.10	11	544	2012-10-03 11:45:05	2003-08-07 14:31:15	6	2	381	0	215	658	140	200.80	49	46.95	CHANGED	GGPIDsRtsPTsVNpLApc+sh-WFcpNlIhpVPhsYPGtGRcVYPGFLQLuGFlSMNhDRHlpAHhDhatcLV+GDG-pA-+HpcFYDEYLAVMDhoAEFYLpTVcpVFpcatLPpGchtpcGphVDhssIpcsALhTVEGENDDISGlGQTpAApcLCsuIPcs+KtaahQsuVGHYGVFsGpRaRppIhPplt-FIcchs	....................................................................GGPI.DsRtsPTsVNpLAp...p+shsWFcpNlIppVPhsaPGtGR+V..YPGFLQhsuFhuMN.-RH.h.puHh-happL.lcGDs.s.sA-tHRcFYDEYh.A.VhDhsAE...aYL-TlcpVFQcatLsp.Gphph...c.....G......c.....h.....VcPssI.+csALhTlEGEpDDIoGsGQTcAApcLCoulPssp+p+ahtsssGHYG.lFsGpR.WRppIhPtlccFIpp.s..............................	0	42	108	152
+6679	PF06851	DUF1247		Protein of unknown function (DUF1247)	Vella Briffa B	anon	Pfam-B_5762 (release 10.0)	Family	This family contains a number of hypothetical viral proteins of unknown function approximately 200 residues long.	25.00	25.00	29.90	194.50	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.89	0.71	-4.55	17	44	2009-01-15 18:05:59	2003-08-07 14:34:31	6	1	39	0	0	43	0	148.50	51	72.01	CHANGED	LGDVlQpMGRp.shLLtc..KKD--FcIspph-LS-ps+-YLNhLQpEKLapCRLCYp+sDph..RC-FH++YlFspstchphD-YVpFLNS-MGllSaVELYYsYLus...ss.W+hsAphhL+cLTsFpSlp-LLsaYNYphspDsDsssaEhMD	LGDVlQpMGRp.phLLpc..KKD.--FcIsEph-LS-ps+-YLNhLQpEKLapCRLCYp+scsh..RC-FHKKYlFccshchtsD-YVpFLNS-MGlISaVELYYoYLus....ss.W+hsAphhL+-LTuFpSlpcLLsaYNYshssDsDpssaEhMD.	0	0	0	0
+6680	PF06852	DUF1248		Protein of unknown function (DUF1248)	Vella Briffa B	anon	Pfam-B_5811 (release 10.0)	Family	This family represents a conserved region within a number of proteins of unknown function that seem to be specific to C. elegans. Note that some family members contain more than one copy of this region.	21.80	21.80	21.90	22.70	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.10	0.71	-5.00	10	63	2012-10-02 22:59:21	2003-08-07 14:38:07	7	2	5	0	60	63	1	176.10	26	53.84	CHANGED	p-slDllhNPs-chlDsaMKhaGNpRhsFK+EDIupW+cSFsDtY+htlhsLKGTs+lItosHslpF+PLsss.c.psahalGhuWIcP-YRG+ssh+lh-shsppct+s.psDNhlApssphupsFW+KhpG...+sDhGH...plhYlSaYchpDhplP-cL-hsG...IsVKNAREVPc+DIlcYDpol	..........................h.tsl-llhNPspchhDpah+...hh.Gp..p.R.hsF+psDlphWppuFcc.YphhhsshKs...............T..........s.....cllussphhpapslp...s.c.tshhhhGhhahsP-YRupsh.h.+.lhsphhhc...hpp.s.ssN.ssu.p.sss...phtp..happhhG...tpchuc....hhYhShYchs-lhlPcs.LshsG...lhlKss.p-VstcDllpYDpsl.................................................................	0	18	22	60
+6681	PF06853	DUF1249		Protein of unknown function (DUF1249)	Moxon SJ	anon	Pfam-B_11475 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.	25.00	25.00	31.30	31.00	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.54	0.71	-4.48	50	853	2009-01-15 18:05:59	2003-08-07 15:20:06	7	1	849	0	120	359	264	119.90	59	83.45	CHANGED	h+Lh+LLPstcp..sp...shphphs......................shph......plcllEso+YToh.............................................lclspptsts..........hhssPplpVRlYHDA+hAEVlsspphp+lcshYsYPNtpMaphDEKhQlNtFLu-WLpaCLcpG.....pph.tsl	.......................QLRRLLP+sDu..sGE.....oVuYQVu............................sspY....RLTIlESTRYTTL.............................................VpIc...QTsPulo.........aWSLPSMoVRLYHDAhVAEVCSSQQ.Ia.RFKARYDY.P.NKKLHQRDEKHQINQFLADWLRaCLAHGAhA..lss.......	0	23	49	86
+6682	PF06854	Phage_Gp15		Bacteriophage Gp15 protein	Moxon SJ	anon	Pfam-B_11759 (release 10.0)	Family	This family consists of bacteriophage Gp15 proteins and related bacterial sequences. The function of this family is unknown	19.90	19.90	20.90	20.70	18.70	19.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.38	0.71	-4.75	9	188	2009-01-15 18:05:59	2003-08-07 15:23:09	6	1	166	0	19	164	6	160.00	27	87.85	CHANGED	pLs-slhchapacsp-YplDLSFcsVL+la-lhcDcplosspKsplslclLh...........ttphhph.cctsplhlcIhppaIsh-p..c-tlphDlcGN.MP.......ptp..pc+hhsappDA-aIaASFhQsYpIsLlcppsK......................LpWhcFpALLsuLs-sThhppIIpIRphEhsp..ptstcERpplhKLKstYpL	..................................................................................................L...h.p.h.htsttatlshsFppslphhplhp.Dp.plst..+h.hhlphhh.......................sh..tp.t...hhh.....hhp...phl.ht....t......c...ss.h.....................t....ppthhshp.Duch..IYuuFhptY.sIcL.hcp.p..sc......................hpWhcFpALhpuLs.-c...T.hppIltIRsh-.sp....ttspc...c+cphpchpphYtL..........................................................	1	12	17	19
+6683	PF06855	DUF1250		Protein of unknown function (DUF1250)	Moxon SJ	anon	Pfam-B_11942 (release 10.0)	Family	This family consists of several short hypothetical bacterial proteins of around 70 residues in length. Members of this family seem to all belong to the order Bacillales or Lactobacillales. The function of this family is unknown.	21.10	21.10	21.50	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.19	0.72	-4.44	47	1637	2009-01-15 18:05:59	2003-08-07 15:27:40	7	2	984	4	102	381	1	46.20	35	64.48	CHANGED	hAspsapDpsFPKpspcacclSsYLEh.susah.shssFDcuaptY.	..LA-hhhcDtuFPKpscc.....acplpsYlcp.ss.....shp.shsshDchaphY....................	0	20	45	79
+6684	PF06856	DUF1251		Protein of unknown function (DUF1251)	Moxon SJ	anon	Pfam-B_12000 (release 10.0)	Family	This family consists of the N-terminal region of several hypothetical Nucleopolyhedrovirus proteins of unknown function.	19.80	19.80	20.30	23.70	18.00	17.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.72	0.71	-4.61	20	50	2009-09-10 22:02:51	2003-08-07 15:30:53	6	1	41	0	0	50	1	118.40	34	54.34	CHANGED	chslssKs+sshh+a.................KVplplss..sscalQATFsstpcpVslVN.psppc.IlFDGFsc..-DEutTsPFlV.GsLhul....pspp.hthpVRchscAhEs.pTlL+lFlNEAhl..psshss	................hslss+s+pshh+a.h...............+Vhlpl-u...sspalQATFpst..pcpVslVN.psppp.lhFDGFsc...-DEupThP..Fll.usLpsl.....pssp..shcV+-hscAhEp.sThL+lFlNEAhl..tsph.s.............	1	0	0	0
+6685	PF06857	ACP	MdcD;	Malonate decarboxylase delta subunit (MdcD)	Moxon SJ	anon	Pfam-B_12010 (release 10.0)	Family	This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins.  Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit [1]. The family also contains the CitD family of citrate lyase acyl carrier proteins.	25.10	25.10	26.20	26.00	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.80	0.72	-4.07	40	1378	2009-01-15 18:05:59	2003-08-07 15:34:27	6	3	1149	0	198	624	11	86.00	40	84.14	CHANGED	cIpcsAlAGTLESSDl.VplsPu.s.sslplplpSs..Vt+QFGppIcpllpcsLpphuVpssplplsDKGALDCVl+ARlpsAltRAsc	.........cIppsAlAGTLESuDlhIpltPhps..p......s...........l..clplsSS..VpcQFGctI+pslh-sLs..+hsVpusplslcDKGALDCll+ARlpsultRAu.t..........	0	44	96	143
+6686	PF06858	NOG1		Nucleolar GTP-binding protein 1 (NOG1)	Vella Briffa B	anon	Pfam-B_5853 (release 10.0)	Family	This family represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). In S. cerevisiae, the NOG1 gene has been shown to be essential for cell viability, suggesting that NOG1 may play an important role in nucleolar functions [1]. Family members include eukaryotic, bacterial and archaeal proteins.	20.90	20.90	20.90	22.30	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.76	0.72	-4.09	25	503	2012-10-05 12:31:09	2003-08-07 15:51:30	9	15	386	1	340	554	80	57.60	51	10.12	CHANGED	sIEhQAIsALsHLpuslLFlhDhScpCGY...olcpQhcLacpI+slF.spPlllVlNKhD	............sIEMQuITAL.AHLRus.lLYhhDlSEQCGa...olcpQl.pL.Fcs.I+PLF....s....N.K...P....lllVhNKsD...........	0	115	195	278
+6687	PF06859	Bin3		Bicoid-interacting protein 3 (Bin3)	Vella Briffa B	anon	Pfam-B_5564 (release 10.0)	Family	This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation [1]. Note that family members contain a conserved HLN motif.	21.00	21.00	21.20	21.10	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.38	0.72	-4.07	5	294	2012-10-10 17:06:42	2003-08-07 16:17:37	7	11	155	6	192	292	6	98.80	41	22.77	CHANGED	cFDVILCLSVTKWVHLNWGD-GL++hFRRIYppL+PGGlLILEPQuWDSYcKR+KlSEslppNYpsIcl+PDcFpcaLlsscVGFpohE.LsulssusSKGF.cRPIhlFpK	............paDllLCLSlTKWlHLNaGDpGLpphFp+laphL+s...........G..GhLllEPQsWpsYp...+t....c....p........h...s............c.......p...h....h....pp....a.plp......h...hPp...p..F.t....phLht....l.GFt................ht................s.....h.pR.l.hh............................................................	0	71	95	146
+6689	PF06861	BALF1		BALF1 protein	Moxon SJ	anon	Pfam-B_12069 (release 10.0)	Family	This family consists of several BALF1 proteins which seem to be specific to the Lymphocryptoviruses. BALF1, inhibits the antiapoptotic activity of EBV BHRF1 and of KSBcl-2 [1].	25.00	25.00	27.50	27.10	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.05	0.71	-4.86	2	16	2009-01-15 18:05:59	2003-08-07 16:34:37	6	1	13	0	0	16	0	171.80	39	88.56	CHANGED	M.....TDsVF.cs......APs.ss-DchscushLhhRsMhAsahpD..pGLsh.thlhhRLIKt.hKK-cKhaA-lsspsus.sshHuHlphlhohhRAlY-DHhD.W.RlRslhshsVsaAhRNh.sDpEsAuhlLsuhAcaLsLYRRhWhuRhGGh.huLRRtFPlpWhhhtls..hhp.	.............................................clucoS.lhh+shaAVho.pD..c-.LslsttVLscLlKtSl++sh+las-.Lssps..uchuuccs+lphlhsllRtsYsDphD.apRLpssLsYsslahshsh.sDpcssuhVhsslA+ahshaRphWhuRlGGhspuLR+pFPspWshspLp.aLpp.h......	0	0	0	0
+6690	PF06862	DUF1253		Protein of unknown function (DUF1253)	Vella Briffa B	anon	Pfam-B_6227 (release 10.0)	Family	This family represents the C-terminal portion (approximately 500 residues) of several hypothetical eukaryotic proteins of unknown function.	19.10	19.10	19.10	19.10	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.50	0.70	-6.08	36	368	2012-10-05 12:31:09	2003-08-08 10:01:07	7	4	289	0	255	543	41	379.60	36	61.37	CHANGED	KoRs+llKNsp+Lpcptp................t-.-hRDQGFTRPKVLIllPhRssAhchVph.Llplhss...............pphcN+p+FpcpF.......ppptss............ppK.....PcD....................applFpGNsD.DhF+l.....GlKh..o+Ksl+LY......SsFYsSDIIlASPLGLchllps...........................................................sp......KKc-hDFLSSIEllllDpschl.MQNWpHltplhcalNphPpc.t+s.sDFSRlRhWhlsspA+haRQTllhosa.sPphNSlhsppstNhpG+l+hpshhpt.....................................uslsp.........lslpl+QhFpR..hc........usSlhsssDsRFcaFsssllPplh........sshtsssLIalPSYhDalRlRNYh+..........ppsloFusIsEYosppclsRuRphFhpG+tplLLhTERhHaa+RYplKGl+pllFYu.Pp.PpFYsEll.phlstost...............hc.s.ssspslYSKaDuhpLERIVGscRAsphlpup.pc...sapF	..........................................................................shll+sstpltt.t.t.....................p.-hRDQGhTRPKV.LlllPhRpsshchVph.lhp..lh.s.......................p.ps+pRF.ppas...........tts...............................+.....PpD..........................apt.lF..t.G..N...D...DhF+l.....Glph............s++o.......l+la......utF..YsSDIllASPLGL+hhltt................................................................ttt...........+cp-hDF.L.S....SIEllllDpA-hh.hMQ.NW-Hl.....hlh.p.plNh.Ppc.....tHs..sDhuRl.R..WhLss.u+ahRQTllhosh..s.sp.hsulhs.p....h...sh.....NhtGplphps..t........................................................usltp.........lhl.pl....QhFpR..hc.........sps.hh.p..s.D..s..RFpaF...sp.....pl..l.Pphh...........ss..stsLIa..lPSYhDaVR...lRNa.hp..........ppplsFstIsE......YoptpplsRARphFhpG.c..tphLLhTERhHaa+RYp.l+...G..l+pllaYthPp.PtFYsElh.sh.lttstt.....................................tthsspsla.o+aDshpLpplVGspRstphhpsp..tssa.F............................................................	2	101	152	218
+6691	PF06863	DUF1254		Protein of unknown function (DUF1254)	Vella Briffa B	anon	Pfam-B_5911 (release 10.0)	Domain	This family represents a conserved region about 130 residues long within hypothetical proteins of unknown function. Family members include eukaryotic, bacterial and archaeal proteins.	22.20	22.20	22.20	22.30	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.93	0.71	-4.31	340	950	2012-10-01 20:00:45	2003-08-08 10:59:30	7	11	469	9	332	860	184	127.90	25	28.84	CHANGED	hNphhphp.thhs.tp..pslls...sNsDTlYohuhlDL.pssPlllplP.s.h.s.Rah.shtlhDhappsh.....................h.....st........ststuGp.ah..l.ssPsa...........................................ts.p.......................hh...cusTshshllhRshs......ps.ssD..hss.l.....pt.lQcthp..lts	..............................sph.hhp.th.sssp...pslss.sNsDTlYohualDL.sssPlllplP.s..h.t.RahshthhDhappsh................sshst..........stspuGp..al.l.ssPsa........................pG.h...........hh.hhcssTphshlhhRshh......ps.spD...hts.s.pt.lpcthplh................................................................	0	80	165	252
+6692	PF06864	PAP_PilO		Pilin accessory protein (PilO)	Moxon SJ	anon	Pfam-B_12430 (release 10.0)	Family	This family consists of several enterobacterial PilO proteins. The function of PilO is unknown although it has been suggested that it is a cytoplasmic protein in the absence of other Pil proteins, but PilO protein is translocated to the outer membrane in the presence of other Pil proteins. Alternatively, PilO protein may form a complex with other Pil protein(s). PilO has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body [1]. This family does not seem to be related to Pfam:PF04350.	22.50	22.50	22.70	25.40	20.70	22.40	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.40	0.70	-6.12	9	257	2009-01-15 18:05:59	2003-08-08 11:01:29	7	1	201	0	33	208	3	375.10	26	91.58	CHANGED	salAGLcWpshsp.tp+ssRphu+s.........tsAshhluhphtspptpuphphsuhls....h.httpphaSLAhhhLshhtssGYGIapLspt....pahFlAsssGl.ushuDlVGotsplhpAhppFLshN.sPpp............uWpshusspassshpohstsLSs.....pthRts+LstVtps.phhhhullhlLhuhhh.ua.happ..scsthhststphtActph..ptss.s.....ls.PWAshP.hssFLptChslhpslPVolAGWRhshucCss-G....lRhpYpthsGuTlscFupRlp-la..sppPsFsLs-GuppGslhlPhshp.sppshpsEslPssusQl.+hsSahQphplplslsElpss.shst.Dtps....hP...W+EYsFphpTplsPctlhs..phs-sGlRhsSlshpLps.GpFpYphcGpl..YAp	................................................................................................................ahssLpWp.hst....t....p......pp.....t+.t..........shphhh........ttp..tphhh.suhlt....................thpth..aSLAhhhts...hp...s.....h..hu.........l..apl...s-t.......chhalAsh.sG..t....sh..u..D.lsGs.pp-l.t..pth....ph.ahshs...t.s.t..............tW.p.lh......p....s...c.hs..s..s...p....p..h...t.t..Lss.....................tp..+hs.....pLs.....l....t.p...ptph..hhs..ul....l...h.h..l..s...s..s.u.hs.s.a...a..p.p.p..t...c...s..h..h...s...t...stph.t.Actph.t....pp.s..p.s.s........ls..P.Wss.PshssFl.cuCss...h...h.pt.P...lult.G.W+hstupCssps.....hphhYpp..tsu...uTh..t..sF.t....pscpla......sshPshsl.sG.p..usl.shsl.....s.shs.ht.D-sls.ssp..l.clhoh...hQphpl..p......t.l..s.....E...h....s.........s......s....hss.stps.............P..pW+paphsh.p........osls.P.p.tlh...hhp....t.sGlRlpplthplpt..uphpap.pGplYup..........................................................................................................................	0	10	18	24
+6693	PF06865	DUF1255		Protein of unknown function (DUF1255)	Moxon SJ	anon	Pfam-B_12498 (release 10.0)	Domain	This family consists of several conserved hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown	25.00	25.00	38.90	38.10	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.04	0.72	-3.72	85	1071	2012-10-10 13:59:34	2003-08-08 11:06:28	6	2	1050	2	221	522	128	93.60	55	95.56	CHANGED	hhcsNhYFDGpVpShuhphs-hscpTlGVMhPG-.....YpFuTutsEhMplluGshpVpLPGps.....cWpsasuG-sFpVsANSsFpl+Vp...psosYlCpYh	.....MlpuNpYFsGKVKSIGFspussG+ASVGVMs.GE.....YTFuTupPEcMTVlSGALpVhLP.sss.....-WpsapAGpsFsVPGpScFcLpVs...E.sTuYLC+Yl................	0	53	122	175
+6694	PF06866	DUF1256		Protein of unknown function (DUF1256)	Moxon SJ	anon	Pfam-B_12377 (release 10.0)	Family	This family consists of several uncharacterised bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.94	0.71	-5.05	13	439	2012-10-01 20:58:29	2003-08-08 11:11:13	6	1	326	0	117	354	6	163.40	45	84.31	CHANGED	hlphs-tpAhhpltshLppal.......scclVllCIGTDRssGDuLGPLVGphLKphphs.hpVYGTLc-PVHAlNlccplccIcKcapsPaIIAIDACLGcs..pslGcI.lcstPlcPGpuVsKpLPsVGDlSIsGIVNlos.hEah...lLpssRLphVhchAcsIupu	.......................h..hpp..u.tplssh...Lhshl..h........ppsl.lllC..IGTDRSTGDuLGP......LV.Gop.L.......cp.....h...t.h...s..p...h...pV.aGTL...-c.....P....VH..........A..........h..........N...Lc.............-...plppIpp....pas.ssaIIAlDA.CLGch..ps..l..G.p.IplupGPl+PGuuVsKcLPsVGDlpIsGIVNls..Gh.hE..ah...VLQNTRLslVMcMA-lIup.u.........................	1	58	95	104
+6696	PF06868	DUF1257		Protein of unknown function (DUF1257)	Vella Briffa B	anon	Pfam-B_5975 (release 10.0)	Family	This family contains hypothetical proteins of unknown function that are approximately 120 residues long. Family members include eukaryotic and bacterial proteins.	21.00	21.00	21.90	21.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.24	0.72	-4.14	40	175	2009-01-15 18:05:59	2003-08-08 11:32:11	6	1	109	0	65	168	172	102.10	35	80.65	CHANGED	pALpDLGhphcp.sp.ptVRGY..cGQT.hpA-lsl...p.ssuhDIGFpWNusp..YELVsDLphWp..Qslsl-cFLsploQ+YAhpolLspospp.....GFplsEpppspDGSIcLV	.........................uLpDLGl...shcp...tp..tsVRGY..pGQp..hpA-lll....p.s....ssYDlGFphNuss..Y-Llu.D..hWp....pphshppFl..splsQ+YAhpplLscsppp.....GapssppppttsGshpl................................	0	19	47	63
+6697	PF06869	DUF1258		Protein of unknown function (DUF1258)	Vella Briffa B	anon	Pfam-B_6065 (release 10.0)	Family	This family represents a conserved region approximately 260 residues long within a number of hypothetical proteins of unknown function that seem to be specific to C. elegans. Note that this family contains a number of conserved cysteine and histidine residues.	26.50	26.50	27.30	26.90	26.30	25.40	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.70	0.70	-5.30	3	40	2009-09-13 14:59:23	2003-08-08 11:37:06	7	5	6	0	40	38	0	189.30	29	31.56	CHANGED	AEEARKLWpYsKNNFSTHsYCNtCGK.VLuspcKCNhCssuPVATFVRIGuFSQI+ELVEoYlD-ILEIREQLKsGRNl-HNLuSPFFS+aWcsESpNHL+LSTVlSIDGV+ISGNKKKLWPVSLlLVDLPoGLMQKSTNlILEGIVECSENPSTsLWNALIPhIhSDVEuHoGRV+NITFoC+ITTCSADQPAKRAFFGF+uHSSuhSCFFCLSPETLYK+GGssRKEpRPGaLTIlDScNGcNGFosKsSKIV.HVl	............................................................t.Ch....tp.t.t.......s..............s....t............t.hhpa..hRhshhtQl.pllptah.cIhpl+cpLppupphpHsLsu.ahp.chht..p.E..pt.ptL.plohl.hulDGlpl...tG.s.p....pKlWPlohhllDLPsu.MQ+ssslllpulhEsppsPSThlWNtlhshlhsDhptt.ttlts.hphphhIho.hsuDQ.....P................A.....+R..shauh+uHpup.SC.ashs.tThhKhts...................................................................	0	4	13	40
+6698	PF06870	RNA_pol_I_A49		A49-like RNA polymerase I associated factor 	Finn RD	anon	Pfam-B_20222 (release 10.0)	Family	Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures.  Deletion analysis of the fusion yeast  homolog indicate that only the C-terminal two thirds are required for function.  Transcript analysis has demonstrated that A49 is maximising transcription of ribosomal DNA [1].	20.10	20.10	20.20	22.00	19.00	20.00	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.15	0.70	-5.89	24	337	2009-01-15 18:05:59	2003-08-08 12:05:22	7	10	258	10	242	330	1	321.60	20	82.87	CHANGED	psspsscFsLYKcc..........p..pschllpGE.s-+LcYsGps.ssss.ps......cYhVGlaD.popplclapA.hhsh...........cssscsccshct.thcp.sss+shppR.suLGEAFGT+K......uK+AlsshccN+lc........u-pLpcsthcls-sltpsstshsspp-h.p.sssss..+PhP.sNl-AsslE-lYsl-sIIspcEashlc.lsshltppcspccLp.hhP..sp.upaVtc+L............................................tpLtptpsh.....c+lplLaYlSlLlslhpp.........RplppKpsLhp+ht.....sP-lllsslLc+FThsp.....pstphphhI..ssppc-KLlsYllslhLHlc.sFhV-lssLu+-Lslcss+lhpla+slGsplKt.s.sphpthulscussssaKlAoL+lPh..+hPchpcct...+R	.............................................t..............................ptphlltup.ptplpahupp.t..t.t...............pah...lulhs.pstphp.lh.s...thh.h........................................t...ttp....t..........t.....t.ttp.htt+....ptLhpsF.GopK......t+.+sl...ps.hp..Nt....ls...............................sp....t....h.....p.....t.....s....t..thh........p....s...h............p.s...p...t..s.......s..........pph.t......t.pts.....p.lP.hshsAs..psp-lY.hcs................ll..s..t....t.....h.p..h..lt........t..h......tt.tt...tptl..........t...spalh....ppl...............................................pt.l.........t...........tp......t...........pp......hph...lhalph..Llthhtt.......................................+ph..+pt..hhtt..............................hPchl.ptlhppFss........................p....hh...stp.tshlhsahhslsLhl............s....sa...t.s...-...hssLtp..-L..p..hp...pphhphh+tlGsplpt..................................tt.tthc..hupLtlPh....hPt..tptt...................................................................	2	81	127	193
+6699	PF06871	TraH_2	DUF1259; 	TraH_2	Moxon SJ	anon	Pfam-B_13298 (release 10.0)	Domain	This family consists of several TraH proteins which seem to be specific to Agrobacterium and Rhizobium species. This protein is thought to be involved in conjugal transfer but its function is unknown. This family does not appear to be related to Pfam:PF06122.	26.30	26.30	27.30	31.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.22	0.70	-4.88	8	33	2012-10-03 00:09:25	2003-08-08 12:48:21	6	1	21	0	11	38	0	194.50	55	98.47	CHANGED	MLDAALIKcCADPSLKPAIVEQFlsuAGSsDPLAVTV+SGsRllLVPKsTTsDEAMAlIRQalGpslVRVGLTQaPAGVGVp-Au-LKPDLVDACENlRhGTAhFAKVhRIVsKWYGNPTucDVhPQlF-DAlhAWKTG.FEGluVFpA-DPGsussspssstss-cs.pscsouc.ssustssspsups.s-ss+AGIRIDLStIGu	.MlDAALIcpCADPuLKPAIVEQFlttAGSsDPLAVTV+SGsRllLVPKspTsDEAhuLlRp.lG+s.lVRVGlTQaPAG.lGlh-AupLK.sDLVDsCcNlRhGTALFAKVhRIVsKWYGNPTsp-VhPQlF-DAIhAWpTGhFEGsuVF+A-DPGsss....hspssstpptps.tppsssp.tsus..s..sstsups.sDsspAGIRIDLStIGu.........................................................	0	1	4	8
+6700	PF06872	EspG		EspG protein	Moxon SJ	anon	Pfam-B_13549 (release 10.0)	Family	This family consists of several EspG like proteins from Citrobacter rodentium and Escherichia coli. EspG is secreted by the type III secretory system and is translocated into host epithelial cells. EspG is homologous with Shigella flexneri protein VirA and can rescue invasion in a Shigella virA mutant, indicating that these proteins are functionally equivalent in Shigella.  EspG plays an accessory but as yet undefined role in EPEC virulence that may involve intestinal colonisation [1].	25.00	25.00	69.10	69.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.04	0.70	-6.12	4	134	2009-01-15 18:05:59	2003-08-08 12:57:48	6	1	111	10	1	57	0	370.00	72	98.16	CHANGED	cShhhNuhpNsSA.hsL-uslcVsSshcpsWs-hohAE+LLKlLohGlasPcYotsERpphpcLLolLcPlhPtsNEhG+VtApFSDGSSLRISVTpSE.IEsplpTP-s-Kl.olhLEuNEQNpLLpSL.PlshHMPYIpsH+uLsph-lsstpuM+pLlsFsuKLSTolIPasspTcPLSGsTPFsSlahDThRGL.....GNoKlSlNGV-IPtcAQtLLpstLGLKDTtSSPspNlIppGIshcpAppIlpcSpssp-.....QKAhlsshLCpPEhsoAICSAFYQSFsVPAhhLpH.RIphASpa.upRSLshP..............NAsl...sIuISpSSsGulaVoSpsGshIMAPc-RsNtlGhhT.RTSYEVP.Gs+Cp.sEhsRslpP..+YuuSEsY.pN	.......MINGLNN..sSASLVLDAAh+VNSsFKKsWs-MSCAEKLLKVLSFGLWNPTYoRSERQoFQELLTVLEPVhPhPNELGRVpApFSDGSSLRISVTNSELlEAEIRTs-NEKI.olLLESNEQNRLLQSL.PIshHMPYIQVHRALSEMDLTDssSMRNLLuFTSKLSTTLI.PHNsQTDPLSGPTPFSSIFMDThRGL.....GNAKLSLNGVDIPssAQKLLRDALGLKDTHSSPsRNVIspGISRHcAEQIARESSGSDc.....QKAEVVEFLCHPEAATAICSAFYQSFNVPALoLTHERISpASEYNuERSLDsP..............NACI...NISISQ.SSDGsIYVoSHTGlLIMAPEDRPNEhGMLTNRTSYEVPQGVKCpIDEMVpsLQP..RYuASETYLpN........	0	0	0	1
+6701	PF06873	SerH		Cell surface immobilisation antigen SerH	Moxon SJ	anon	Pfam-B_13151 (release 10.0)	Family	This family consists of several cell surface immobilisation antigen SerH proteins which seem to be specific to Tetrahymena thermophila. The SerH locus of Tetrahymena thermophila is one of several paralogous loci with genes encoding variants of the major cell surface protein known as the immobilisation antigen (i-ag) [1]. 	22.00	22.00	23.60	22.10	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.07	0.70	-13.87	0.70	-5.85	11	200	2009-01-15 18:05:59	2003-08-08 13:01:24	6	9	2	0	192	207	0	156.00	17	99.89	CHANGED	MpsKsLlICLll.......pphhlSVhSshsGssVsCss..ssssCssosssssPshtG.....CSW...........sGsssssCtIsDCsClsss...ssoGLTDhFCpSCtuss......ssaANsAGoACVuoSuSCssspps.....sWssuDCsLCsPsTPAhsut.......uCsACSu.....hoSuaTDusCsACuo...............suoshspslFANoAGouCVAuSASCsSsSRuss...AWTsuDCthCsPso......Phhsus.p.sssoSCsusossToGhTDupCNuCu...................ssuSssspslFANsAGSuCVAoSAoCsouspuss...sWTsuDChhCsPsTPuh...hu..ssooClA......Csuhoos.WTDAsCsuCh.sASsssps...............lFAsusGSuCVAuohSCNtosRuSNpWTDuDCALCNG............................Tuss.uNQYASuDGSSCQuTp......sSuThSuphhlShLLlhSuLLI	....................s.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	192	192	192
+6702	PF06874	FBPase_2	Firmicut_FBPase; 	Firmicute fructose-1,6-bisphosphatase	Moxon SJ	anon	Pfam-B_13194 (release 10.0)	Family	This family consists of several bacterial fructose-1,6-bisphosphatase proteins (EC:3.1.3.11) which seem to be specific to phylum Firmicutes. Fructose-1,6-bisphosphatase (FBPase) is a well known enzyme involved in gluconeogenesis [1]. This family does not seem to be structurally related to Pfam:PF00316.	21.50	21.50	21.60	21.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	641	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.95	0.70	-6.48	33	868	2012-10-02 19:15:56	2003-08-08 13:13:26	6	1	816	0	91	645	36	621.00	51	98.14	CHANGED	h+YLcLLScpaPTlspsuTEIINLpAILNLPKGTEHFlSDlHGEYEAFpHVL+NGSGsl+cKIcDlFu.ssLscsEKppLATLIYYPc-KL-ll+p..ppc.slc-WY+hT.....LhRL....Icls+hsuSKYTRSKVRKALPc-FuYIIEEL.Lacpsctss.KcpYYspIIpoIIclscA--FIlAluplIQRLVVDHLHIVGDIYDRGPts-hIMDpLh...pYHSlDIQWGNHDlLWMGAAuGscsClANVlRIusRYuNLshlEDuYGINLhPLAsFAhchYp.csPC.sFpPKh...st.phsppEhphls+hHKAIuIIQFKLEuplI+R+PEFcM-cRhLLc+Isa-cuTIsL.sG+pYtLpDTsFPTlDPpsPYcLTpEEc-ll-+LhtSFhsSEKLp+HhcFLhsKGuhYLhYNuNLLaHGCIPLsEDGshcphpI..tGcpYpG+pLLDhh-phlRcuah.pcspppcchupDhhWYLWsGtsSPLFGKccMTTFERYFIpDKpTHpEpKNPYYpLR-cEclCcpILcEFGLss....cpuHIINGHsPVKsppGEsPIKANGKllVIDGGFSKAYQppTGIAGYTLlYNSYGhpLVoHpPFpSpccAIpctpDIlSsphllEpsspR+pVpDTDlGpcLppQIpDLctLLtAY+pG	................................+YLcLLuppasohpchuTEIINLEAILpLPKGTEHFlSDlHGEYEAFpHVLRNGSGsl+pKIp-lFt.spLsppEhs-LssLlYYPE-KLpLlcp....ppp..p..h.psWYhhTlp+L....Iclh+hsSSKYTRSKVRKALPcpasYIIEEL.Lacss.c.h..ps.Kc.sYYppIlpplIplppA--a...IluLuhhIQRLllDHLHlVGDIYDRGPtPDpIMDpLh...sY.H..S..lDIQW..GNHDlLWhGAhuGScsClANllRIsARYsNL-llEDuY.GINLRPLhsaAtchYp...s-s...tFpPKht..tpp..phsppE.p.ls+hHpAIulIQFKLEstlIcRRP-FcM-cRllL-KIsa-pssIs.l.pGp.......pYsLp....DosF.Tl.....s.....s....csPhcLstEEc-lhs+LhhSFppSEKLp+HhpFLhpKGShYLsYNuNLLhHGCIPlsEsGphcshpl..p.G.c.p.Y.sG+pLLDhh-hhlRcua.....s...pt........p....p....pc....chusDhlWYLWsGchSsLFGKctMoTFERYFIs..D......KtoH+EcKNPYYp.L..R..-.ct..p......hsc+ILcEFGLss....-puHIINGHTPVKphcGEsPIKAsGKhlVIDGGFSKAYQppTGIAGYTLlYNSaGhQLVuHpsFsupEcslpps.tDhhSh+pll-p.phpRphl+DTshGccLppQIptLchLhcsh..t......................................................................	0	39	65	82
+6703	PF06875	PRF		Plethodontid receptivity factor PRF	Moxon SJ	anon	Pfam-B_13241 (release 10.0)	Family	This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity [1].	19.40	19.40	19.50	19.70	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.30	0.70	-5.12	2	260	2012-10-02 01:28:15	2003-08-08 13:18:57	6	1	58	0	45	239	0	204.80	59	94.64	CHANGED	RSTSLLTFLVVSLSTATSLAMAEINDVADLSSDTIVhFSEVQKFAEDIQSSADSLLPTYLSFQGAPLSDPDYQLPHIKVsNLPTAAMDYDTFh+QTDETRLpNNLYFYSAIVEFLKEAMTEQEDLNPAELuLKAKFEEAMANSNTLISKISDIMTQMGMSVTITLPKPLVVPFcGSAYFpKKLRGGVVCKEYKERVhLTKRDF.hLAcKYQG.L	............................................RSTuLLTFLVVSlSoATSLsM......A......-hs......DVA-LSpDTIVLFSEsQKFAEclQSsADSLLsTYLSFQGAPLSDPDYp....LP+.IK.V.s.NLPTAsM.DYDTFhpQTDEsRLpNNLYFYSAIVEFL+tAMTEQE.DLNPAELuLKAKFEEAMANSNTLISKISsIMTQMGMS...V.....TITLP..c..PL.V..VP..F...c.G.SAhFpKKLRGGVVCKEYKERVhLTKRDFphLAcKYQG.................................................................	2	1	4	13
+6704	PF06876	SCRL		Plant self-incompatibility response (SCRL) protein	Moxon SJ	anon	Pfam-B_13253 (release 10.0)	Family	This family consists of several Plant self-incompatibility response (SCRL) proteins. The male component of the self-incompatibility response in Brassica has been shown to be encoded by the S locus cysteine-rich gene (SCR). SCR is related, at the sequence level, to the pollen coat protein (PCP) gene family whose members encode small, cysteine-rich proteins located in the proteo-lipidic surface layer (tryphine) of Brassica pollen grains [1].	21.80	21.80	21.80	22.00	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.14	0.72	-4.01	43	154	2012-10-01 23:31:40	2003-08-08 13:22:27	7	1	12	1	49	160	0	65.60	27	86.40	CHANGED	Fll....SHsQ.-VEAshh........C..tppsasG.pCussGscp............Chpphpp.....hcpcshpCpCs......tthpsp+hCsC..ph	......................hp.-VEA.shhpt......C...tp..tt.hs.G.pCu..ssGs.p.p............Chpthpp.......hpppshpCpCp.........t.pppphCpCp.h..............	0	25	26	28
+6705	PF06877	RraB	DUF1260;	Regulator of ribonuclease activity B	Moxon SJ, Bateman A, Eberhardt R	anon	Pfam-B_13601 (release 10.0)	Domain	This family of proteins regulate mRNA abundance by binding to RNaseE and inhibiting its endonucleolytic activity [1-2]. A subset of these proteins are predicted to function as immunity proteins [3].	23.30	23.30	23.30	24.80	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.79	0.72	-3.38	67	1287	2012-09-25 12:41:39	2003-08-08 13:24:37	6	5	1101	1	189	635	25	103.70	42	67.55	CHANGED	h.pppspcllptLhcsGs.-.st.a.lEaahhhsc.cphcchutchhptGac.lps.tp.............-c.ss..shathphstphhhshctIsptpppl.plApchssp.YDGWGs	.............Qc-ETR.IIcpLLEDGS.DP-uLYsIEHHlss.cDh-sLEKAAV....-AFKhGYE.Vs-sEEh.........EsE-Gc....hlhssD.lhs.Ess...Lss-hIDuQV-pLhsLAEKassp....YDGWGT...................	0	32	79	135
+6706	PF06878	Pkip-1		Pkip-1 protein	Moxon SJ	anon	Pfam-B_13784 (release 10.0)	Family	This family consists of several Pkip-1 proteins which seem to be specific to Nucleopolyhedroviruses. The function of this family is unknown although it has been found that Pkip-1 is not essential for virus replication in cell culture or by in vivo intrahaemocoelic injection [1].  	25.00	25.00	116.10	115.90	24.30	19.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.69	0.71	-4.36	19	40	2009-09-14 12:00:35	2003-08-08 13:28:33	6	1	39	0	0	37	0	162.40	33	93.32	CHANGED	stIcphpsK.NslhcQa-pKVhsahpKss.s................-sttp-hhhLuAplaG.pEQL.uLpp..ssscpc+.h-FlsDl.s-L.Dhssp-lcphhptsc.s......ahhpKYpssph.pthppsac.p..pFlKhhcpFlsKRps.h.............hp........sss....sshL-ELVhLKsslIKHLCshEpLs	....pIcplpsKcsslpcpY-pKVhsah+Kss..................-stts-hhhluAplaGhcEQLhuLpp..stsccc+.l-FlsDl.s-L.Dhss--l-plhttps.s......hlspKYpssp.l.....scslppsa-pptppFlKllcpFlsKRss.a.............++........ssssplL-ELVhLKsslIKHLCshEpLh.	0	0	0	0
+6708	PF06880	DUF1262		Protein of unknown function (DUF1262)	Vella Briffa B	anon	Pfam-B_6733 (release 10.0)	Family	This family represents a conserved region within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that some family members contain more than one copy of this region.	19.80	19.80	20.60	41.10	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.33	0.72	-3.69	9	75	2009-01-15 18:05:59	2003-08-11 13:15:06	6	3	13	0	52	73	0	99.20	45	26.52	CHANGED	EGPsSGlLVlp....DEcutsc..pCaGhCh..csplpGLPFPQNptLoVca.........psGpGcsphsa..tDsVVFlPVlsQPLSSNRYYsl+tsG+HuGcssAso.+EEDtVoCCFC	..............EGPNSGhLVIp....DE-upsp...s.....C..aGhsh..c.s.pl.c.sLPFPQNppLsVpa.............................ptstsppp.sh..h-sVlFIPVLsQPLSSNRYYslct.pGKH.pGpspssu..+E-Dhss..CCF.................	0	10	25	36
+6709	PF06881	Elongin_A		RNA polymerase II transcription factor SIII (Elongin) subunit A	Vella Briffa B	anon	Pfam-B_6598 (release 10.0)	Family	This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin [1].	25.30	25.30	25.30	25.50	23.90	25.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.16	0.72	-3.67	21	318	2009-01-15 18:05:59	2003-08-11 13:51:23	6	5	229	0	221	299	0	106.30	27	22.28	CHANGED	lp-lGslPaplLcPlLc+s.os-QLhclEcts..PtLhp-oD-LWpcahpRDF....................ccph.p-.-.......sWR-hYh+hp-cpcp+h....cpLppplppspsp+spt.+p.....hhlpsh	..................lt-lGs.lPaplLc.PlLp+s...os-QLhclEc..ps.....stLhp-...oD...cLWppahp+DF...........................................cp.p..t.spc.h-........................oW+-hYh+hpcpp-pcl........ptLppshpstptpK.pt.pt...h.....h.......................	0	66	111	176
+6710	PF06882	DUF1263		Protein of unknown function (DUF1263)	Vella Briffa B	anon	Pfam-B_6668 (release 10.0)	Family	This family represents a conserved region located towards the C-terminus of a number proteins of unknown function that seem to be specific to Oryza sativa.	21.60	21.60	24.30	23.80	21.10	18.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.36	0.72	-4.43	8	155	2009-09-10 17:20:14	2003-08-11 14:02:11	7	12	3	0	132	154	0	86.80	58	53.41	CHANGED	MG+..sp.cSAGSRCNV..tutLSADDhTGVRPVTDRSFLSTTRQFShLHVCPSSYNDFLAMVuMKPGhYLsGTDVPoPGssTPAPARDECLEALIlPTGhGEACsRPPlAT	.....................................................................................................o.hsDFLAMluMKPGM.LsGTDlPTPGVsTPAPARDEs.EALIIPTGRGEACsRPPVAT...........................	0	0	0	0
+6711	PF06883	RNA_pol_Rpa2_4		RNA polymerase I, Rpa2 specific domain 	Finn RD	anon	Pfam-B_4721 (release 10.0)	Domain	This domain is found between domain 3 (Pfam:PF04565) and domain 5  (Pfam:PF04565), but shows no homology to domain 4 of Rpb2.  The external  domains in multisubunit RNA polymerase (those most distant from the  active site) are known to demonstrate more sequence variability [1].	21.30	21.30	22.40	26.50	21.20	20.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.91	0.72	-4.01	31	319	2009-01-15 18:05:59	2003-08-11 14:20:06	7	28	270	0	214	329	3	58.50	41	5.23	CHANGED	lGalssctApplsssLRhhKlt..........s.ppplP..............pLEIuaVPso...ps..GpYP.GLYlFossuRMhR	...........lGass...c.tuttlucsLRhhK..Vp...................u..ppplP..............pLEIuaVP.o.....ps..GpYP.GLYLFossuRMhR............	0	77	123	181
+6712	PF06884	DUF1264		Protein of unknown function (DUF1264)	Vella Briffa B	anon	Pfam-B_6839 (release 10.0)	Family	This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 200 residues long. Some family members are annotated as putative lipoproteins.	25.00	25.00	34.70	27.90	18.80	19.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.12	0.71	-4.81	28	339	2009-01-15 18:05:59	2003-08-11 15:00:49	6	7	284	0	133	261	2	167.10	51	67.11	CHANGED	shsPlcplstHLsu..........FHhYucDPsR.plEApHYCs.+lsE.......DhtQCllYDussssA+LlGlEYlISt+LFpTLPs-E++LWHoHsaEV+SG.Llh............................Ps.....lPps....AE+stMcclhshYGKTaHhWQs....DRGDsLPLG.PpLM..huFop-uplc........tLlcpRDc+h.Glss...ct+RcpRt-.lpts	...........................p..sPlctIssaLsu..........FHhYusD......hst....QhEAHHYso.hLNE...............DlhQslIYDus.sps.ARL........hGVEYIISE+LFcT.LP.sEEKKLWHSHpYEV.......KSG.Lls.................................PG.........lPps........s-+shMpcllsTYGKTWHTWps.....DRsc.......sLPhGhPtLM..MuFT..sD..GQlcs.......sL.lt-RDcRh...GlDTpth..+cpRp-.ls.........................	0	41	76	110
+6714	PF06886	TPX2		Targeting protein for Xklp2 (TPX2)	Vella Briffa B	anon	Pfam-B_6863 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [1]. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.73	0.72	-3.90	20	364	2009-01-15 18:05:59	2003-08-11 16:21:19	6	9	95	0	225	353	0	56.10	38	11.62	CHANGED	h+o-cRAccRpEF.pKlcEKppthctppppsEtppcpEEEptl+QLRKpLV..aKApPh	........h+s-cRAccRp..E.....F.p+lcEKppthE..tp+pptctppc..............EppEp-.l+pLR.K.p.Ls..aKApPh......	0	58	137	180
+6715	PF06887	DUF1265		Protein of unknown function (DUF1265)	Vella Briffa B, Pollington JE	anon	Pfam-B_7101 (release 10.0)	Family	This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be restricted to C. elegans. The GO annotation for this protein indicate that its a protein involved in nematode larval development and has a positive regulation on growth rate.	25.00	25.00	59.40	58.40	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.35	0.72	-4.30	7	20	2009-09-11 00:32:59	2003-08-11 17:07:06	9	1	4	0	17	22	0	47.90	52	15.25	CHANGED	EELhpNhEDlhYVppLLllAcsu+hpslpssC.ATll.aHhpDFhR.h	.EELhKNaEDlhYVCNhLIlA-Du+FsslpsCClATllhYHFsDFhR....	0	10	13	17
+6716	PF06888	Put_Phosphatase		Putative Phosphatase	Vella Briffa B	anon	Pfam-B_7115 (release 10.0)	Family	This family contains a number of putative eukaryotic acid phosphatases. Some family members represent the products of the PSI14 phosphatase family in Lycopersicon esculentum (Tomato) [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.64	0.70	-5.20	9	337	2012-10-03 04:19:28	2003-08-11 17:25:44	7	8	166	0	194	898	85	208.20	31	78.97	CHANGED	hlllFDFD+TIIDtsSDshVVcthssppl.ppLpsoh....WNphMsRhhp.LpsQG.hs.t-l+psl+slPlsPthlchl+th..ps.th-LhIlSDANpFFI-phLcttulpshFsc.IhTNPushDu.pGpLpltPYHs.....Ho.Cs..hCPsNhCKGhVl-chhspt..pcGhthcRllYlGDGssDaCPsl+LppsDhshPR+GaPhachlsc....ssthl+ApVh.WssGt-lpchLhtll	........................................................................lllF.DF...DpTIl-..p.....s..........S..D.........s..h.........l......l.....p.......t..h.........s..t.....p.........p.....h...........p...p.....L...t....t...p.....h....p.....................W..s..p..h..M...........s....c.hhp.............L...........t.p..p.......u.....h....p............p.......c........l..t....p.....s.........l..................p.p.....lP....h...s..s..th....h.p.hl..ph.h..............t...t.........s.............h-..lh..llSDu.NshaI-phL....ctt.u...........l..p.p.....h..Fs..c..lhoNP.u.t.h.......s..t.....pG......p.....L....p....l....p......P...aHs.............................Hs..Cs.....hC....P....s..N...h...CK..t.......tl..l.p.....c.hhpp........................t..u.h................hp.+..llYlGDGssDh....CPshp.LtttD.hsh.sR......+..s......a....s..h..chltp...........p...hp..u.plh.Wpsu.-l.p.h...................................................................................................	3	60	104	151
+6717	PF06889	DUF1266		Protein of unknown function (DUF1266)	Moxon SJ	anon	Pfam-B_13878 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 235 residues in length. Members of this family seem to be found exclusively in the Enterobacteria Salmonella typhimurium and Escherichia coli. The function of this family is unknown.	21.80	21.80	22.20	21.90	20.70	21.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.90	0.71	-4.46	66	1230	2009-01-15 18:05:59	2003-08-12 09:14:11	6	6	645	0	86	576	3	174.40	29	66.70	CHANGED	pptLppsWGIsc+c....shhpplptlh..spGcp...............................................................hthhpphtp.htthttttspphththphhpth..................htttuhhAWDhuRhshlsRh...uhhsGalsccEshphhhpsuppspptasSWc-ahtuYhhGpthWtssssppphtttth...............pLhpssp.........uPat.................t.ls........Wp	.............................................................................................................h..sLpspWGIpsp-shhphl.phh......sssHu........................................................sphts.htphhcps.....p.hpchhsths.-p.sp.....thsp..alutp..............................suttsIhAWDhsRMuaLoRh...ushNsalsEE-uhal..psth+A..pchacoWccYhsuYhhGRhYW.....ps.sps.c..pphhht...chht.h................plhtssc....paat...........sLPWp..................................................................	1	32	58	75
+6718	PF06890	Phage_Mu_Gp45		Bacteriophage Mu Gp45 protein	Moxon SJ	anon	Pfam-B_10848 (release 10.0)	Family	This family consists of Bacteriophage Mu Gp45 related proteins from both phages and bacteria. The function of this family is unknown although it has been suggested that family members may be involved in baseplate assembly.	30.10	30.10	30.30	30.10	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.98	0.71	-4.79	8	376	2009-09-13 01:58:40	2003-08-12 09:25:51	7	2	328	0	52	300	4	162.70	32	86.85	CHANGED	uRAVVoulssspKpQslQl+lhAGEspDcVE+LpsYGaoSsP.sGAEAllshsGGcRSHuVsVVVsDRRaR.pGLpsG-VuLYccEGcplpLT+sGclI.sus.......Kolplp.......uuppspF-oP.sphTGslcsssD.u..............Gsshus.cpstshsh.GHtH+-susGus	...........................RuslshlssutphQsl.Qlp.h.husEstsslE+hp.YGF.oS.s.s...sGuEulllhlG....GcRS+uVllslpc.ccYRhpG.LpsGEsAlYs.c.pG.p..p.lpLp.+.tGhl.lcsss..............................cs...lplp...............AsspsphpsP...lps.oGp.lpspss.s...............................utshss....t.h....shs.........sHpHppsstt..s...........................................	0	12	26	42
+6719	PF06891	P2_Phage_GpR		P2 phage tail completion protein R (GpR)	Moxon SJ	anon	Pfam-B_10918 (release 10.0)	Family	This family consists of P2 phage tail completion protein R (GpR) like sequences. GpR is thought to be a tail completion protein which is essential for stable head joining [1].	25.00	25.00	27.00	26.80	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.44	0.71	-4.37	48	720	2009-01-15 18:05:59	2003-08-12 09:29:35	6	5	527	0	86	497	3	130.00	37	85.41	CHANGED	M..........hK.ppL+shLhssl..sphtsss-p....lcsal-sGplhsssp..u.uh.........chpYshslhlpcass...csshlhsslhsWLpspps-...p.c..tcppshpFcl-l.scsss......DlpIplp.LsEclhltcct......sGtlph....pttt.s	..........M...KspSLRpALscul...shhpsNP-p....LplFV-sGslhsTut..ohSa................-aRYslslhlpDasG...-.shLhsPlLsWLc-NQPDlh..ssp..h+ppshsFps-I..cs-ss......DlslsL..LTERVllsps.......pGs..thpth....................	0	8	34	60
+6720	PF06892	Phage_CP76		Phage regulatory protein CII (CP76)	Moxon SJ	anon	Pfam-B_13444 (release 10.0)	Family	This family consists of several phage regulatory protein CII (CP76) sequences which are thought to be DNA binding proteins which are involved in the establishment of lysogeny [1].	21.30	21.30	21.70	21.50	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.70	0.71	-4.92	15	350	2009-01-15 18:05:59	2003-08-12 09:37:11	6	2	313	0	50	250	8	153.50	44	91.22	CHANGED	-apsSKps....+FDpACpsFAspaNlscLAccsGhss.QhLRNKLNPpQPHpLTssELltITchT.sDpTllsuhLhplsslsss.Pssps...uc....sl.ppslcsoupsG-luptAlph.uscRlTpspKcpllppApuuIppLuLlhtslEsRhQ.AsPshuhssDslsu	.....................DaphSKHs....HFDpACRuFAlcH..N..h..s...pL..Ac+sG..Mss....QsLRNK..L..N..P.p.Q.P.H.p.L.TssElhhLTDlT..EDuTL......lDGhLAQIp..CLP.s.V....P...lNEs.....uc....tpLs.chVhsAT....A-lGclAus...AV...S..s-.hhTsutR...+shlsslNushRhhuLhAhslpuRlQ..usPshsuuVDslo.u.......................................................	0	7	19	38
+6722	PF06894	Phage_lambd_GpG		Bacteriophage lambda minor tail protein (GpG)	Moxon SJ	anon	Pfam-B_11957 (release 10.0)	Family	This family consists of Bacteriophage lambda minor tail protein G and related sequences. The role of GpG in tail assembly is not known [1].	19.20	19.20	20.40	20.20	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.77	0.71	-4.51	7	773	2009-01-15 18:05:59	2003-08-12 09:47:44	6	2	336	0	10	332	0	122.70	54	90.90	CHANGED	MFLKoEpFpasGsSVsLSELSALQRIEaLpalppcstph-sp......uccpssh.phslchsAaLVuhSLWcu.........s.sp-spplpppVhtsWsh-AluputphVLhLSGM......psssppsspss	...........MFLKTEpFEYNGVSVTLSELSALQRIEaLAhlppcAEQ.t...Eos.........uscpl...sl.....cc...hlcTuAaLVAMSLWHsHs.Ks.p.sShsEsVppIcQEVlTTWPs-Alup..ApssVLpLSGM..hshpsssssppstc..t..................................................................................................	0	0	1	4
+6724	PF06896	DUF1268		Protein of unknown function (DUF1268)	Moxon SJ	anon	Pfam-B_11819 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.	21.90	21.90	22.40	22.10	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.44	0.71	-3.74	4	65	2009-01-15 18:05:59	2003-08-12 09:56:36	6	1	61	0	12	57	1	118.20	23	90.05	CHANGED	Mc...IKlsclpc+oaEVKTS.+NlcKMacaQLshActp-pIusups.p.sclshsh.......LcshltFloslLsLsKcEh-KL.t-LEhpchhclsshlVthh.GhoD-pI-pu.sccsDs..uc	...............................................l.h....p..l....p+shpVpsospslc+hpch....Qlthhctp...s.plp..csp.t.h....phhch...phph.............lcchhcFlpplLsLsccph-Kl.-c.l.-hpchtchsshlsh+lp..GhsDcplchs.tpp.....p................	0	3	6	10
+6725	PF06897	DUF1269		Protein of unknown function (DUF1269)	Moxon SJ	anon	Pfam-B_14034 (release 10.0)	Family	This family consists of several bacterial and archaeal proteins of around 200 residues in length. The function of this family is unknown. The family carries a repeated glycine-zipper sequence- motif, GxxxGxxxG, where the x following the G is frequently found to be an alanine. As glycine-zippers occur in membrane proteins, this family is likely to be found spanning a membrane.	22.40	22.40	22.40	22.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.01	0.72	-3.99	40	415	2012-10-03 03:18:43	2003-08-12 10:27:11	7	3	359	0	124	303	40	101.70	31	38.74	CHANGED	AluGuhWGhLlGllFhsPLlGh....AlGAuuGAluGu.Lo..DhGIsDsFl+-lucsLpPGooALFlLl+csssDKVlpclptas..GcllpTSLSc-cEppLpcALspu	.......................................htGuhhGhLlG.llh..hs..slhGh.......................AlGAusGAluGs...hs...D...hG...Ic...D...s...h...h...cclupsLss.Gouulhlls.cc.ts.-cVhs.s.lp.shs..upllppsls..tt..l.t.....t..............................	0	53	82	106
+6726	PF06898	YqfD		Putative stage IV sporulation protein YqfD	Moxon SJ	anon	Pfam-B_13823 (release 10.0)	Family	This family consists of several putative bacterial stage IV sporulation (SpoIV) proteins. YqfD of Bacillus subtilis (Swiss:P54469) is known to be essential for efficient sporulation although its exact function is unknown [1].	25.00	25.00	26.40	29.80	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.05	0.70	-5.76	8	428	2012-10-01 23:48:22	2003-08-12 12:30:40	6	2	409	0	89	349	7	353.90	27	95.03	CHANGED	KhpappFh+GhVplclpGhsIE+FLNhshppsI.lhsl++hsspslshplsLpDhKKl+plsK+spCKlphlcR+GhPFllhRh+++hulllGhllFllllahLSshlWcIDIpsscshsEa-lRppLs-hGVKpGshpFsl-.lpKlp+cLhpshssIhWlGVclcGTol+lcVVEKppP...-.tpps-PpNlVAKKcGhIpRlaVpcGpslVKlsDhVKKGDlLVSG.lGpEspcpt............VsAcG-VhAcTWYEsplcV.LpsphpshTGcshssaalphtuhplsl...shpcpEFccacp.pcp+sh.hh.aphPhphs+pphYEspppptchsK-EAVccutKhuccclpcplucsuclhscKVh+cclEsGKl+LplhhpV.EsIu	...............................................hh.Ghlplclp.G.hshE+FlN.shpptlhlas.l........p+hs.ps.hhhph.lp-h+cl+slh++sps+lpllp+hG.hPFhht+hh+.ppsh.hlGhllFhhhlhhhSshlWpI...-I..p...Gs..p....s..ophtlhptL...c.c.h.Gl+.Ghhphpls.spclpcplpp.ph.s.s.lsWlulclcGTphplcls...E...+p.pP.................phtp.pppP...........p...........slVApKculIpchhsppGpslVphsDhVcKGplLlS..G.h.h......s..p..c..tp...t........................V..p....AcGpVhuc..T..aYpt.ps..plslppp...hp...hh.TGpphpp.hhlphsstpl..hl.........s..h..tp....ppac.ph.c.p.p...pp.ph.p.h.h.t.h.h...l.P...lthtpphhhEhcphptph...o....c...cpAhphutchspc.plppp.l....s.pp.s.pIls.......c.......p...l.h......p..h...c..s..splchplhhps.EsI...............................................	0	47	74	79
+6727	PF06899	WzyE		WzyE protein	Moxon SJ	anon	Pfam-B_13849 (release 10.0)	Family	This family consists of several WzyE proteins which appear to be specific to Enterobacteria. Members of this family are described as putative ECA polymerases this has been found to be incorrect [1]. The function of this family is unknown.	25.00	25.00	29.40	28.60	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.74	0.70	-5.79	3	583	2009-09-11 10:39:43	2003-08-12 12:41:03	6	2	559	0	43	231	0	431.40	85	99.60	CHANGED	MTLuQFGGLFVVYLLullFIATLTYpEFRRVRFNFNVFFSLLYLLTFYFGFPLTClLVFRFGVuVVPVEhLLpALLSATuFYGIYYVTYKTRLRpRsus.PRsPlFTMNRVETNLTWVLLALIALuTVGIFFMQNGFLLFRLcSYSQIFSSDVSGVALKRFFYFFIPAMLVVYFL+QDpRAWlFFLlSTVAFGILTYlIVGGTRANIIIAFALFLFIGIlRGWITLWMLAAAGVlGIVGMFWLALKRYGLNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYD+IDFQGLAPIVRDFYVFIPSWLWP-RPSLVLNTANYFTWEVLsNHSGLAISPTLIGSLVVMGGVLFIPLGAIVVGLIIKWFDWLYEpGKAEoNRYKAAILQSFCFGAVFNMIVLAREGLDSFVSRVVFFCVIFGACLllAKLLYWLF-oAGLI++...RTsuLshsNAts	............MSLhQFSGLhVVWLLsTLFIATLTWFEFRRVRFNFNVFFSL.LFLLTFFFGFPLTSV...LVFRFDVGVAPPEILLQALLSAuCFYA.VYYVTYKTRL...R..............KR.V........u.......D...VP.....R..RPL.F..TMNRVETNLTWVILMGIALVSVGIFFM.HN.GFLLFRLsSYSQIFSSE.VSGVALKRFFYFFIPAMLVVYFLRQ...DSKA.WLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGh...NVSGDEAFYT.....FLYLTRDTFSPW....ENLALLLQNY..DN..IDFQGLAPIVRDFYVFIPSWLWPGRPShVLNSANYFTWEVLNNHSGLA.............I..SPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREsNRYKAAILHSFCFGAIFNMIVLAREGLDS..FVSRVV.FFlVVFGACLhlAKLLYWLF-SAGLIHK...RTpS..psQVEG...............	0	1	11	27
+6728	PF06900	DUF1270		Protein of unknown function (DUF1270)	Moxon SJ	anon	Pfam-B_13907 (release 10.0)	Family	This family consists of several hypothetical Staphylococcus aureus and phage proteins of 53 residues in length. The function of this family is unknown.	20.60	20.60	20.60	23.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.89	0.72	-3.82	2	250	2009-01-15 18:05:59	2003-08-12 12:43:48	6	1	175	0	2	69	0	52.40	89	98.91	CHANGED	MSNIYKSYLVAVLCFTVLAIVLMPFLYFTTAWSlAGFASIAhhIFaKEYFYtc	.MSshYKSYLlAVLCFTVLAIVL.M.PF.LYFTTAWSIAGFASIATFIFYKEYFYEE...	1	2	2	2
+6729	PF06901	FrpC		RTX iron-regulated protein FrpC	Moxon SJ	anon	Pfam-B_14005 (release 10.0)	Family	This family consists of several RTX iron-regulated FrpC proteins which appear to be found exclusively in Neisseria meningitidis. FrpC has been shown to be related to the RTX family of bacterial cytotoxins. FrpC is found in the meningococcal outer membrane. The function of this family is unknown although it is thought to be a virulence factor [1].	25.00	25.00	162.40	162.10	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.83	0.70	-4.88	2	63	2009-01-15 18:05:59	2003-08-12 12:52:41	7	1	29	0	4	51	0	244.80	90	99.31	CHANGED	MRPYATTIYQLFILFIGSVFTMTSCEPVN..............EQTSFNNPEPMTGFEHTVTFDFQGTKMVIPYGYLARYTQDNATKWLSDTPGQDAYSINLIEISVYYKKTDQGWVLEPYNQQNKAHFIQFLRDGLDSVDDIVIRKDACSLSTTMGERLLTYGVKKMPSAYPEYEAYEDKRHIPENPYFHEFYYIKKGENPAIITHhNNRlNQsEEDsYSTSVGSCINGFTVQYYPFIREKQQLTQQELVGYHQQVEQLVQSFVNNSsKK	....................................MTSCEPVN..............EQTSFNNPEPMTGFEHTVTFDFQGTKMVIPYGYLARYTQDNATKWLSDTPGQDAYSINLIEISVYYKKTDQGWVLEPYNQQNKAHFIQFLRDGLDSVDDIVIRKDA.CSLSTT.MGERLLTYGVKKMPSAYPEYEAYEDKRHIPENPYFHEFYYIKKGENPAIITHRN..+....phtEssYSTSVGSCINGFTVcYYPFIRE......K......QQLTQQELVGYHQQVEQLVQSFVNNsSKK....	0	4	4	4
+6730	PF06902	Fer4_19	DUF1271;	Divergent 4Fe-4S mono-cluster	Moxon SJ	anon	Pfam-B_13906 (release 10.0)	Domain	Members of this family contain three highly conserved cysteine residues. This family includes proteins containing divergent domains which are most likely to bind to iron-sulfur clusters.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.32	0.72	-4.15	22	670	2012-10-03 08:56:42	2003-08-12 13:05:51	6	12	636	0	116	1472	82	63.60	50	63.97	CHANGED	YpGtplslhhstslCtHuupCl+...stPpVFc.tc+.PWl.....pP-suss....cplhphlspCPSGALsahcc	...........YoG-cIDVaaN.ssIC.p.HSGNCVR...Gss.c..lFsl....c...R...K....P....W...I.................hP..D...p.s.sl..............s.s...l.l.cV..I.-.o.CPSGAL+YpcK............................................	1	45	79	101
+6731	PF06903	VirK		VirK protein	Moxon SJ	anon	Pfam-B_13955 (release 10.0)	Family	This family consists of several bacterial VirK proteins of around 145 residues in length. The function of this family is unknown [1].	20.50	20.50	30.20	39.70	19.70	16.40	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.11	0.72	-4.26	14	134	2009-01-15 18:05:59	2003-08-12 13:13:00	7	1	124	0	27	101	2	97.70	37	70.18	CHANGED	spsLsshsplhp.ALssGKsVslslDLspCpsp...sssssssps+GGhpIcuahIssDsoluFuDpHFTlssc...G+PlhpFlRYplps-Gssphssh....shshPsap	.........s.sLsshsslhpALssGcsVslslDLupCpsc....tss.ssps+GGhplcuahIpsDsoluFSDsHFTlssc...scPIppFhRYplpssGsspFsshhhshssh...........	1	6	10	17
+6732	PF06904	Extensin-like_C		Extensin-like protein C-terminus	Vella Briffa B	anon	Pfam-B_6925 (release 10.0)	Family	This family represents the C-terminus (approx. 120 residues) of a number of bacterial extensin-like proteins. Extensins are cell wall glycoproteins normally associated with plants, where they strengthen the cell wall in response to mechanical stress [1]. Note that many family members of this family are hypothetical.	23.50	23.50	23.60	24.90	22.80	23.40	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.40	0.71	-4.50	81	626	2009-01-15 18:05:59	2003-08-12 13:17:00	7	3	464	0	171	507	50	171.40	35	62.79	CHANGED	sshChssLsttG....sph..sslssts....tsuCultssV+lpt.....suslslsssshh..sCshAtuhstWhcpslpPAApphhGp..slsplcphuoYuCRshsst...........u..u+lSEHApusAlDluuFpLsDGpcIoVhcsWp..s......spctpaL+pl+cuAC.thFsTVLGPch.sshHpDHFHhDh......uGht....hCR	............................................s..Ch.th.Lp...tts....h.h..pp.....h.sshp...ssupCslspslclps.......husltls.s..u.h.hh..sCshAhshAhalcpslpPsApphh.tp..plspIcphGoYuCRsh.pp.............s...u+hSEHApu..............sAlDluuFpLuD..G......+c.IsVh.cs.W.t...p...............tcpt...s....aL+...slps.......uuC.....phFssVLG.Psh....Nu.sHt...sHFHlDh...........suhthC+..................	0	33	86	125
+6733	PF06905	FAIM1	FAIM; 	Fas apoptotic inhibitory molecule (FAIM1)	Moxon SJ	anon	Pfam-B_13985 (release 10.0)	Family	This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology [1].	20.70	20.70	21.30	20.80	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.25	0.71	-5.10	7	135	2009-09-11 08:59:28	2003-08-12 13:19:24	8	6	84	3	95	143	0	165.10	43	80.59	CHANGED	Mo...................DlVAhWDVsLuDGlH+IpFEHGTTSGKRVlaVsG+EllR+-WMFKLVGcETF.lGstpsKATIpI-AlSG..FuYEYoL-IsGKSLcKahEsRsKso+sWlhplDG.....t-hRlVL-KDTM-Va.....sNGpph-TtGEFs-sGo-T+FohusapChIpuhSSGpKRpGIlHpLllDGhc......lsps	..........................-lVAhWsVsLs.DslH+IEFEHGTToGKRllhVDG+.EhlR..+....-.WMF.KL.V...GcETF..plG...ps........+ssI...pIDAl.....uG.....Fs.YEYoLclsGKSLc+.......ahEspoK.phpoW.l.hpl.s.G................p.chRlVL-K..-T.h-l...W.........................sNGpph.Eo.su...EFV-sGT-.T+Fplu..sp.s.shIpAh.SSGp++pGIlHsLhlssptls.h....................................	0	22	27	74
+6734	PF06906	DUF1272		Protein of unknown function (DUF1272)	Moxon SJ	anon	Pfam-B_14128 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 80 residues in length. This family contains a number of conserved cysteine residues and its function is unknown.	23.10	23.10	23.20	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.32	0.72	-4.12	35	286	2009-01-15 18:05:59	2003-08-12 13:22:27	6	1	282	0	95	231	22	55.90	62	72.70	CHANGED	M.LELRPNCEsCD+DLPP-u.-AhICoFECTFCssCs-shh.pslCPNCGGpLltRPhR	...M.LELRPNCEpCDpcLPsDS.-AhICo.aECTFCAsCs-ph..pshCPNCGGELVcRPhR..	0	14	45	64
+6735	PF06907	Latexin		Latexin	Moxon SJ	anon	Pfam-B_14203 (release 10.0)	Family	This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat [1].	25.00	25.00	26.10	26.10	18.90	18.10	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.50	0.70	-5.18	4	94	2009-01-15 18:05:59	2003-08-12 13:28:15	7	2	41	3	42	84	0	188.10	41	88.21	CHANGED	slsss+thhphAApsALHahNa+pGSPStLhlLtpVQcupuhh.PpcGpKhalhFSTEpY.......cGE.phGpCoAcVha..hsppPtPsVNsTCs+hhsKpphQEEDaphYcphppLKpPLcu.sIPDsaGpIsssh+.lWcLAalGSSYVMWcpoTpsoaYhLsQloSV+QhppsDDsI-FDaTVLLHEluTQEIIPC+haLVWaPG+PlKVKYpC..-ppu.EE	......................................hsssph.htpAAtss.phhNhptGoPptlhhlttVppup.hp........PtpGpKaplpFosEch..........p.tp.hhspCoAcVha....tspcs..tP.t.lphThpt.ht.Kp..pc-D.thYpph+p.h+pPLpu.sIP.D..saGplsPphpPlhcLAhlusuY..lhWppoTEpphYhhsplpoV+Qh.pps.D.DhI-hDYslLLH-h.soQ.EIIPhphpllWhPthshK.VKaps...hps..............	0	2	5	17
+6736	PF06908	DUF1273		Protein of unknown function (DUF1273)	Moxon SJ	anon	Pfam-B_14270 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	21.60	21.60	22.10	22.60	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.02	0.71	-4.61	41	1168	2012-10-01 21:16:48	2003-08-12 13:44:34	6	5	1090	1	113	625	5	170.30	37	95.22	CHANGED	M...pplhVTGY+uaELGI.Fp-cDPclplIKpAlc+pLhphlE..-.G.l-WlIhuGpLGhEhWusEVsh-L+p-.YPpl+lAllhPFpspuppWsEsNQt+hpslhppsDFscslsc.psYp.........sPtQh+phspFhlc+TDuslllYDpEpcGpsKYhhchhcchpppp.sYslphlsh--Lp-hs...p-	.....................................M.pslhVTGY+uFE.Lu.l.Fp-.c.cP.clp.hIKpsl++cL...pphl.-..-..G..l-.WllhsG.pLG.hEhWssEVshEL..+..p-..Y.s....lpl..AslhPF..psau.ppWNE.s...NQt+hsphhppsDaVc.lhp.p.Yp............sPtQh+phspFhL-....po-sslLhYD......cE..p.c......up..s.cY.hhpthppht......sY.hchloF-cLpphhp.t..................................................................	0	35	66	91
+6738	PF06910	MEA1		Male enhanced antigen 1 (MEA1)	Moxon SJ	anon	Pfam-B_14358 (release 10.0)	Family	This family consists of several mammalian male enhanced antigen 1 (MEA1) proteins. The Mea-1 gene is found to be localised in primary and secondary spermatocytes and spermatids, but the protein products are detected only in spermatids. Intensive transcription of Mea-1 gene and specific localisation of the gene product suggest that Mea-1 may play a important role in the late stage of spermatogenesis [1]. 	19.00	19.00	19.40	19.40	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-4.60	2	97	2009-01-15 18:05:59	2003-08-12 13:52:09	6	2	84	0	51	84	1	122.60	50	88.78	CHANGED	MAsVVLGGDTMGPERIFPNQTE-LG.HQGPoEGTGDWSSEEPEEEQEETGuGPAGYSYQPLNQDPEQEEVELAPVG-G.DssADIQDRIQALGLHLPDPPLESEDEDEEGAsALssHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWApEISDAQWEDVVQKALQARQASPAWK	.....................................................................................................................................................................................Y.PLs.............t.t.............................t.......t............t.t.....hth..h.h....sp...ss...ps..tDE.-E....E...GAsAhs...s..+S..SIPMDPE.HV..E.l+psMAslsLPs.ulPsWAptls-tpW.cc..l.ptlptpp.....................	1	10	15	30
+6739	PF06911	Senescence		Senescence-associated protein	Vella Briffa B	anon	Pfam-B_7525 (release 10.0)	Family	This family contains a number of plant senescence-associated proteins of approximately 450 residues in length. In Hemerocallis, petals have a genetically based program that leads to senescence and cell death approximately 24 hours after the flower opens, and it is believed that senescence proteins produced around that time have a role in this program [1]. This family extends to the higher vertebrates where the full-length protein is often a Spartin, associated with mitochondrial membranes and transportation along microtubules [2].	21.60	21.60	21.80	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.68	0.71	-4.58	59	334	2009-01-15 18:05:59	2003-08-12 13:54:44	7	9	197	0	227	312	3	172.70	26	36.16	CHANGED	slspG......uspls+GlhtsushsuptlppGuphhpp+.............h...ps.....spp.......s..............h.....plsPps...............ppplc....cl+phopsstplo....pthlssVspsustlusslspphst..............................tthtshhs..lhhuolpuhuplh....DulEpuu+slhpssussosphVpH+YGppAGpls..pcshsssusssh..sshsstpltp+Alh	.............................IhsGuuhlupGllpsu-.hsuptlppGush.hpp+............................h.......pP.......ppc.......P...................................sphsPss...............pcplc.................ts+phottusplo....pt.h..lssVsps.usshutplusphtt.............................................................t.....tp..t.hpsths....lhsuSlpu...Fuslh....sulEpAu+plhsssossssphVpH+YGppAupso..ppshsustsssh...sshsl.tlth+Al......................................	0	86	137	184
+6740	PF06912	DUF1275		Protein of unknown function (DUF1275)	Moxon SJ	anon	Pfam-B_13896 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although a few members are thought to be membrane proteins.	25.40	25.40	25.50	25.50	25.20	25.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.30	0.70	-5.13	176	2258	2009-01-15 18:05:59	2003-08-12 13:56:48	6	14	1641	0	642	1872	52	202.00	21	85.04	CHANGED	htluhhLu.hsuGhlDAhualsh.tthFsut.hTGNhshluhslu..tssht.shth....lhslhuFlhGshhushl............httttthtpththsLhlpsslLhhsuh...lshthss.........................hhshhhluhshGhQsushp..plssssl.sTThhTGsls....shuhsls...phlhtp...st....................hpphhhhhshlsuFhhGullGuhhhphhu.h..hulhhssslhhhlsh.hh..h	...............................h..hshhLs.hsuGh.....lD.Ahsa....lsh.......t.............hasut..T..G..........Nlshluhsls....pssh.t...t....shth.........................lhslhsFhhGshhsshl............................hpphp..h..tph.hhhslhhp..sll.lhh.suh...lstths.............................................hhslhhluashGlQssshp...pl.ss.h.......s.h.sosh.hTGslpphs..hsls..........phhhsp.......pp.......................hpc.hhhhhsllhuFhlGu.lhG.u.hh...h..t..h.hs..h...ts.lhhsshhhhhhhh...h......................	0	157	349	499
+6744	PF06916	DUF1279		Protein of unknown function (DUF1279)	Vella Briffa B	anon	Pfam-B_7316 (release 10.0)	Family	This family represents the C-terminus (approx. 120 residues) of a number of eukaryotic proteins of unknown function.	21.80	21.80	22.20	22.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.12	0.72	-3.68	31	454	2009-01-15 18:05:59	2003-08-12 15:35:11	8	12	287	0	318	442	4	100.30	29	39.87	CHANGED	p+hKplh+cYGhlulusalslShhshuhhYlhVpu....GlD.lsshlpplshs............................................................pshsp.h.ts..shuphslAYul+Khh.tPlRlslTluhTPh	................................................phKphh+cYGhsslslalslShlshshhY......hhlps.....Gl.-...lsshhphlshs......................................................................pshsp.t...h.tsu...thuphslAYulaKhh.hPlRhslTluhTP....................................................................................	0	108	170	257
+6745	PF06917	Pectate_lyase_2		Periplasmic pectate lyase	Moxon SJ	anon	Pfam-B_14500 (release 10.0)	Family	This family consists of several Enterobacterial periplasmic pectate lyase proteins (EC:4.2.2.2). A major virulence determinant of the plant-pathogenic enterobacterium Erwinia chrysanthemi is the production of pectate lyase enzymes that degrade plant cell walls [1].	21.30	21.30	21.50	36.40	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.86	0.70	-6.26	5	122	2009-01-15 18:05:59	2003-08-12 15:38:44	7	1	69	3	19	88	5	490.50	53	98.49	CHANGED	AolhusuupAQDs-RLouVKpYlDNVLsKAuDpY..t+PTPLLADGVDPRTGKQlEWIFPDGRsAVLSNFSAQQNLMRVLlGLSsLTG-s+Y+pRAEcIVRYaFs+YQD-o.GLLYWGGHRFVDLKTLQPEGPSEKEMVHELKNAYPYYDLMFuVDs-ATARFI+GFWNAHVYDW+sLETSRHG-YGK...........sMGuLWQScFEQQPPFFATKGLSFLNAGNDLIYSAS...LLY+aspDsGALsWuKRLAcQYVLPRDsKTGLGVYQFTQPLKR-.EPsDDuDTHSKYGDRAQRQFGPEFGssALEGNMLLKGRTSTLYSENALMQLpLuKcLGssGs-LLcWTlDGLKAFA+YAYNsssNTFRPMlANGpDLSsYsLsRDGYYGKKGTVLKPY.PAsNEFLLSYARAYsLssDs-LW+VARGIApsQGLG-lGsssGu-lKlNMpTsNs-PYALFALlDLYQAoQss-YLcLA-+lGDNllcpRalcGFFlAssc+pYAcVDsIEPYALLALEAAlRNKPsuVAPFLNGAGFTEGuYRhsDGosRVSTRDNELFhLpsGEhLpPNsKK	....................h..........h.hshLosl+pYVD.V.shupsph...pPoPLLADGhDshTtQ.h.W.FPD..G.+csslSNFuuQQNhhRshsuLS.lotDPpYpppAc..spYahQp.h..cpS.GLhYWGGHRFlsLcTLpsEGPupK-pVHELKpthPYYDLhholDp-tThpFlpGFWpAHV.DWchL-huRHGpYuK.......................hssl......uph.p.P...tTKGLoFlNAGsDLIYuA....hhhcYptD..................tuAhsWuK+LhcQYVLsRsscTGLsVYQFops.pRp..PsDDsp...TpShaGDRApRQFGPEF..G.hAhEuNhhh+.chps......Lh.-NsLh.Lplh+p..t.ss-lLpWslDGLKsah+aAYs.psNThRPhhssGQDhSsYsLsRDGYYGtKGoVlpPa..hss-aLlshsRAat....l.spD..Lhclhtslh..c.tLu-ls.........ps.t+t......hph.phppssusPYhLhALl-LhptsQssphhoLA.plGDslh+p+Yh.cGhFhtSsp+pYhclDs..PhALLsL.AAhpNK.tAls.FlssuGahcGsY+hs.GpuRh.hc.s.la........................	0	1	8	12
+6746	PF06918	DUF1280		Protein of unknown function (DUF1280)	Vella Briffa B	anon	Pfam-B_7457 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long within a number of proteins of unknown function that seem to be specific to C. elegans.	25.00	25.00	25.40	27.30	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.25	0.70	-5.15	7	110	2009-01-15 18:05:59	2003-08-12 15:40:44	9	4	9	0	110	87	0	176.60	23	29.56	CHANGED	phhs+pshpp.Rh-phLcthpp...sss-hspFlpphl+hlsppsp.sa+..hoscEThhhht+hcLScsph+phKphh+phlGh-lLsShcplppL+ppLus.spYKlop.hssp....G+hlphhplh....cl.csltcRlEpLstpspLl.Ds..tscIhlslhuDpGutpTKlClsItNsppPNSshpllhluhasssDststlpcahsslh..Lschppl	..............................................................................................................h.......h...ph..hht.htp................t....p.p.hh.thh.phhtpp........php..ho..pshh.......hh.phphopt.hp.hKphhpp....hhh-.h.....sshpphtphpp.hss.p....aphp..........spth.h.....th.h.....slpphltpRLppLttpspLh..hcp....tspIhlsluGDKGuspsKlsl.ltNlppPNsspsllhluhapusDshpslpp.htslhpphNpl............................	0	27	56	110
+6747	PF06919	Phage_T4_Gp30_7		Phage Gp30.7 protein	Moxon SJ	anon	Pfam-B_14625 (release 10.0)	Family	This family consists of several phage Gp30.7 proteins of 121 residues in length. Family members seem to be exclusively from the T4-like viruses. The function of this family is unknown.	29.60	29.60	30.20	69.90	22.80	29.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.67	0.71	-4.12	2	33	2009-01-15 18:05:59	2003-08-12 15:45:57	6	1	32	0	0	18	0	121.30	86	99.55	CHANGED	MNYINFERKYVSNGIAGS.-sICLWKHpNGoVCEIEQhMTPNYVYMRFENGITVSITMcGSNFKIALDDDFRQRDLGTHPCWNGsNRKLLVKTWIRHILSNRAKPEHLEAIFDVVLNEFDI	....MNYINFERKYVSN...GIAGSIDTICLWKHQNGSVCEIEQYM..TPNYVYMRFENGITVSITMEGSNFKIALDDDFRQRDLGTHPCWNGsNRKLLVKTWIRHILSNRAKPEHLEAIFDVVLNEFDI..	0	0	0	0
+6748	PF06920	Ded_cyto		Dedicator of cytokinesis	Vella Briffa B	anon	Pfam-B_7154 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.	20.60	20.60	20.60	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.90	0.71	-4.97	25	1240	2009-01-15 18:05:59	2003-08-12 15:48:52	8	27	253	8	667	1086	2	172.80	32	10.33	CHANGED	T.F-+spslp+Fha-sP..Fohs..G+.sp..G....slccQa+R+TILossssFPhl++RlpV..hpcppl-l............oPIEVAI-plppKstELstthspp...........shphLQhhLQGslsssVNtGPhchAcsFLsp..h....sth.tcphp+L+pshc.........cFhptsppALclpcpLhttc.tp..hpccL-psa.pphpppLps	...........................................F.+s.plp+FhappP........Fp.hs.........s+...tc..........s..................phpc.ahc+TlLT..Ts.p..s...........FPhlh+....RhpV......hp.p..p.p.h.pl....................................oPlEsAI-phppKsp...-...L...pp.h..h....pptt...................................sshp......LphhLpGsV......ss.s...V.N....u.......G.......s....hpY...........tc..s.....Fhscp.h.....................c..stc..+lp...pL+phhp.......................p.h...t..hhtpuLpl.pcc.h.l.t.t.-...pt........hpccLpppa.pphtpplp.t........................................................................................	0	199	276	456
+6750	PF06922	CTV_P13		Citrus tristeza virus P13 protein	Moxon SJ	anon	Pfam-B_14711 (release 10.0)	Family	This family consists of several Citrus tristeza virus (CTV) P13 13-kDa proteins. Citrus tristeza virus (CTV), a member of the closterovirus group, is one of the more complex single-stranded RNA viruses [1]. The function of this family is unknown.	25.00	25.00	184.90	184.70	20.00	18.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.56	0.71	-4.24	3	58	2009-09-11 02:40:01	2003-08-12 16:01:31	6	1	1	0	0	53	0	114.90	92	100.00	CHANGED	MSIRRVWLKVMAVITVLWYGKEPSISEGYNALMNDDFKFIDTHFSNVSYAKKCYDLANFDLDFLRIVIIPLSGGTVNESRADRTNVSEIVESHVSDRDRM+ILLRNKRIQIPSLLPCDN	MSIRRVWLKVhAVITVLWYGKEPSISEGYNALMNDDFKFIDTHFSNVSYAKKCY-LANFDLDFLRIVIIPLSGGTVNESRADRsNVSEIVESHlSDRDRMsILLRNKRIQIPSLLPC....	0	0	0	0
+6751	PF06923	GutM		Glucitol operon activator protein (GutM)	Moxon SJ	anon	Pfam-B_14714 (release 10.0)	Family	This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes [1].	25.00	25.00	30.20	29.90	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.12	0.72	-4.41	26	859	2009-01-15 18:05:59	2003-08-12 16:06:25	6	1	822	0	71	301	39	109.20	43	81.79	CHANGED	hhhL..IlhhshAallQhlLGahQl+pFN+sapplp.....ppG..+VulG+ppG+h+sGsllllulD.cpspllcuphMpGlTVFARh+slsthpGhsltplp...shlhtps+hsppAl	.........................l..sLlslAlIAas..sQluLGhaQIp+FN+sacpLp.....QpG..+VulG..Rs.uG...RF..K.s.pslVhlAlD.-ppRls-shhM+GlTVFAR.pclsshsGhclt-lp....scllhscD.LsQpAl...........................	0	23	39	56
+6752	PF06924	DUF1281		Protein of unknown function (DUF1281)	Moxon SJ	anon	Pfam-B_14730 (release 10.0)	Family	This family consists of several hypothetical enterobacterial proteins of around 170 residues in length. Members of this family are found in Escherichia coli, Salmonella typhimurium and Shigella species. The function of this family is unknown.	25.00	25.00	35.20	35.10	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.61	0.71	-4.76	4	277	2009-01-15 18:05:59	2003-08-12 16:09:33	6	1	198	1	17	220	2	126.30	69	46.55	CHANGED	LhITGpss.lDtlppWssGchlPhYR+AlpQSI+LFLAGCAGlLpP..TcshcYs.aPsLlutGsGtsSspNlAFp+WLsLLppsVsLDtpssp.I-RLYhQSGluphKWEslPssA+cphsslhspphuDWFGls	...........MaFSGEPAQIAEIKRLASG.AVTPhYRRATNEGIQLFLAGSAGLLQs..TEslcaEPCPGLTAA.G......R...G.sVSPENI.AFTRWLTHLQsGVLLDEQNCLMLHE...LWLQSGTGpRRWEsLPDDsR-oITshFTsKRGDWCshW.....................	0	0	4	13
+6753	PF06925	MGDG_synth		Monogalactosyldiacylglycerol (MGDG) synthase	Vella Briffa B	anon	Pfam-B_8075 (release 10.0)	Family	This family represents a conserved region of approximately 180 residues within plant and bacterial monogalactosyldiacylglycerol (MGDG) synthase (EC:2.4.1.46). In Arabidopsis, there are two types of MGDG synthase which differ in their N-terminal portion: type A and type B [1].	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.30	0.71	-4.35	12	972	2012-10-03 16:42:30	2003-08-12 16:37:42	6	10	725	0	253	763	37	160.40	26	40.98	CHANGED	HppuAculp........pthptt.h.pphplhhhDshp.hssh.hphhhps.Yhhhl+h.....u...slathhahhsp.ch.....pshhsthtthhsp.cltshlpchpPDllIsTHPh.tth.l.hL.+p+phh.pshhs.sllTDats.H.hWh+.tlDthalssp-htcchlp.pGlspsplhshGIPl	......................................................................................HhpsApulh........pthpp...........sp.....hplhhhDh..ht.t.t.p.P.h..h..ss.lhpph..Y.hp..h.ch...................h.....ph.at.h.hah..h.s..p.......c.hh........ppph.h.......h....h....p...h....hhh..p....+...lh.p...ll.........p.c......tcPD..l..Il....sTaP.h.........h.l.t...l...+.......p.......c...th....h........s.......l.P.ls...sVlT.D....a.......h.H..phW..lp.st..s.-.tYa.Vuoc.......cs.+p.phlp..hG.lssspltsoGIPl........................................................	0	109	193	226
+6754	PF06926	Rep_Org_C		Putative replisome organiser protein C-terminus	Vella Briffa B	anon	Pfam-B_6517 (release 10.0)	Family	This family represents the C-terminus (approximately 100 residues) of a putative replisome organiser protein in Lactococcus bacteriophages [1].	21.40	21.40	22.30	47.80	20.30	20.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.12	0.72	-3.89	3	25	2009-01-15 18:05:59	2003-08-12 16:56:25	6	3	20	0	5	17	0	91.90	62	35.97	CHANGED	NSLLS+FLDoFINFSSKNISKRAMApsEFlKLPSFQK-QAVIGAcNYIQsYKNEHPDDcTG+YSVNuYsFL-NsMFMsYQEKVKADTGYDEDLGF	..NSLLS-YLDoFIpFSSKNIuK.RAMApsEFhKLsSEpKcQAVIGAcNYhpWYKpEsP-DcTtKFSlNuYsFL..-sshFcsaQpKVKsc...cEsLGh...........	0	3	3	3
+6757	PF06929	Rotavirus_VP3		Rotavirus VP3 protein	Moxon SJ	anon	Pfam-B_14798 (release 10.0)	Family	This family consists of several Rotavirus specific VP3 proteins. VP3 is known to be a viral guanylyltransferase and is thought to posses methyltransferase activity and therefore VP3 is a predicted multifunctional capping enzyme [1]. 	18.10	18.10	52.30	52.30	17.00	16.20	hmmbuild  -o /dev/null HMM SEED	684	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.31	0.70	-6.64	3	582	2009-01-15 18:05:59	2003-08-13 11:02:47	6	3	240	0	0	463	0	551.40	85	83.42	CHANGED	MKVLAL.RRulspsYADTQVYsHDssKDYYENAFLISN.lTTHNILYLD.YSI....KslEILNKSGIAALIhIshD+LtILI+SNFTYDYphcIVYLHDYSYYsNNE.IRTDQaWLTpTNIEEYLLPGWKLTYVGpsGpETRGHYsYSFhCQNTATDDDIIY-YIYS.....NulDF.........pNFlLptlpcRMTTAVPFcRLSNRIFR-+LFS...K..KssINIGPRNESMFThLc..YPpIpNYSANualVSDLI+LsQE+WlGK+ISQFDIGQFKNMhNVLTsIYYYYNhYKuKPpIYMIGSAPSYWIYDl++Y.sFsIETWDPLDTPaSocHHKchFsIsDlcKLKDNSILYIDIRSDRssADWRcWRKpVEEETIpNLEIuYKYLcsGKs+lCClKMTAMDlELPhouhLLHaPTTcI+SEaYLLlDpahLpcpKRFVPKGlhYSFINNIhTDNVFISssYKVKspN-.aVVALYuLSN-hNsR-KVIcasNsQKpolITVRlNNTFcsEh+lsFKosYDaTFLPSDFosc.sTIlTSYDGYlGlFGLSISL-SKuTGNNHLFIlsusccYsplDoFuoHhGISRRSHSlRFSESATThSGYIFRDloNGKFNLIsTNlENuVSGHVYNALlYYRYNYoFDLlRWIpLHupDcVcIcGG+YYEHAPsELlYACcSAhVFApLQsDLTll+YSNclpcYIpsp	...........................MKVLAL.RHSVAQVYADTQsYlHDDSKDEYENAFLISN.LTTHNILYLN.YSl.....KTLcILNKSGIAAVElQS.DELFs.LIRCNFTYDYENNIlYLHDYSYYTNNE.IRTDQHWITKTDI.DYLLPGWKLTYVGYNGKsTRGHYNFSFhCQNAATDDDIIIEYIYS..............NELDF.........QNFLLRKIKERMTTSLPIARLSNRVFRDKLFPSlVshacKVIN.VGPRNESMFTFLN...FP.TIKQFSN..GAYlVKH.TIKLKQE+WLGKRVSQFDIGQYKNMLNVlTTIYYYYNLYaSKPIIYMLGSAPSYWIaDlKQY.SDFpFETWDPL..DTPYSo.h......HHKELFa.pD.VsKLKDNSlLYIDIRTDRtNhDWKEWRKlVEpQTlsNLNIAYKYLuTGKAKVCCVKhTAMDLELPIoAKLLHHPTTElRSEFYhIlDlWDhhs.I.KRFIPKGVhYuaINNlhTENVFIQ....PF...KLKs.p.s-...YIVALYALSNDFNsR...pDVIpLINpQKpuLI....TVR........hNNTFKDEPKVsFKNIY......DWTFLPTDFEhp.-SIITSYDGCLGhFGLSISLuSKPTGNNHLFIlsGTDKY.KLDQaANHMuISRRSHQIRFSESATSYSGYIFRDLSNN.NF..NLIGTNVENSVSGHV......YNALIYYRYNYsFDLKRWIYLH.ShGKsulEGGRYYEHAPIELIYACRSA+EFAhLQDDLTVLRYuNEIEtYINK.V........................................................	2	0	0	0
+6758	PF06930	DUF1282		Protein of unknown function (DUF1282)	Moxon SJ	anon	Pfam-B_14843 (release 10.0)	Family	This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.	23.40	23.40	23.60	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.39	0.71	-4.60	19	937	2012-10-01 22:34:14	2003-08-13 11:06:06	7	8	874	0	113	703	106	178.10	39	84.19	CHANGED	llspPupp.applcpcccshthhhlhhllhhhlhs.ssshhhssh..hhthhst.............s.phohts....uhhhulhshhhh..hhhlhuhh...hphhschas..upss...hppshhhuuYsssPhhluuhsshh.slhhsh.............................shhlhhsaslhLlahGl.hhh..sl.cppcuhhhssh.....hllhsl	.................................................................LaoHPscE.hpsIp..p.Es.E.ol.u+.a....Ys.a..HV..LLhA...u....IP...VlC.....Aa..I..G.T..T.QlGW.s.hG-G.s......................l.pLohho...........ulslAVlhYslhL.....AGVAlMGtl.....I.aW.M.A.RsYs..p+PS.....ls.+ChlFAGYs...AT...PL.F...L.u.GL..V.AL..YPllWLsu..........................................................llGslAL.h.YosYLLYLGlPoFh....sI....s+.-EGl.FSSSsl....ulGl.....Llltlhhh.h.................................	0	19	46	85
+6759	PF06931	Adeno_E4_ORF3		Mastadenovirus E4 ORF3 protein	Moxon SJ	anon	Pfam-B_14868 (release 10.0)	Family	This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon [1].	25.00	25.00	37.60	37.60	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.53	0.71	-4.02	7	84	2009-09-11 07:31:22	2003-08-13 11:13:02	6	1	67	0	0	45	0	111.80	67	97.19	CHANGED	CLRMsVEGALpcLFsMpGhsLpp.hhcIIptW+sENYLGhVQsCuhMIEEh-ss.uFulllFL-VRV.sLLEAsVpHLENRlhFDLAVhFHQcSGG-RCHLRDL+FplLtsRLE	.....CLRMpVEGALpELFpMsGlDLppphscIIQGWKNENYLGMVQ-CshM.I..-El-su.uFsllLaLDVRVEsLLEATVEHLENRlsFDLAVhFHQHSGG-RCHLRDLHFpVLRDRLE................	0	0	0	0
+6760	PF06932	DUF1283		Protein of unknown function (DUF1283)	Moxon SJ	anon	Pfam-B_15035 (release 10.0)	Family	This family consists of several hypothetical proteins of around 115 residues in length which seem to be specific to Enterobacteria. The function of the family is unknown.	25.00	25.00	94.50	31.80	22.40	17.80	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.88	0.72	-3.96	9	515	2009-01-15 18:05:59	2003-08-13 11:31:22	6	2	510	0	40	138	1	84.80	85	74.80	CHANGED	sTs+lVl-SGDoAhS+psAp.sKEQWNDT+uLRpKVNpRsEKEaDKhDtAhDu+DpCppSsNlNAYWEPNT.RCLDRRTGRs.IsP	............ETsKLVIESG.DSAQSRQcAAMEKEQWNDTRsLRQKVNKRsEK.......EWDKADAAFDNRDKCEQSANINAYWE....PNTLRCLDRRTGRV.ITP......	0	1	8	23
+6761	PF06933	SSP160		Special lobe-specific silk protein SSP160	Moxon SJ	anon	Pfam-B_14947 (release 10.0)	Family	This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomus (Midge) species [1,2].	25.00	25.00	25.80	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	756	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.58	0.70	-6.55	2	5	2009-01-15 18:05:59	2003-08-13 11:37:41	6	2	3	0	1	5	0	618.40	65	77.63	CHANGED	MNIKVILVCALVAIFFAQVAEGGPIANFVGFlISLLFSLFEVMlSVVFDVKSFTSLSssTsNuThPuFAopVGGGRFosIhpuoFNhIAMISANlQAIQSGSGSsSusSSSSssSTosSsoTTSssoTTooNSTT.......SSNSTSSGLTouASVVSLIDThAWVYQDSSVGIAYLMVSILALFYGQSVSAPPYsDLGIPALPANsSGsGVPQSVQI+AAIsYlNlTI.FIshTGQQFEDLQGPVsTDCGCPNTTSVAPLVhEWEAIhAALpAhAsuoASuNSTosSsSTosoTTsSsSTTTTNSTToTNSTSSSNSoTIAGsIDIuANhTlALQsLQALLhQEuTCAPsLAANAKKSGVR-huPCKsu..uSuCA+SGp+KVKRKARLEKMRAKsRRAVGNR.KGSMKKRVRSRAKKFGcAAKSGVRRYRKNIKaVYIPPVMASLNAYAALMASLS-SIS.QS-SALNSTDpACNSTussTDtAVIsATssVTDMFsNFTAMVlNNTVAaPNCTQaADMAL.MlSQIN-QIIuCGSQSDsApSSIYhNVTIsIVAMAQEYNNFASMSDKCTRSFANSWLWMYIKWVFYRMGMTSGlPNFLACQTKApSSLTAhLASFNATlsATIuAASANsSpVQSSEAuCIESSLu-AusILtMaEsAYQNCssPGSV..PstssTTTooTTTTTTTTTTAAPTTTTTKAANAPFTYPLCsL.MossCshGhssCTYPhISSAGCCPSGKTLNTGLGGRGCCK	.........MNIKVILVCALVAIFFAQVAEGGPIANFVGFlISLLFSLFEVMlSVVFDVKSFTSLSsPTsNuThPuFAopVGGGRFosIhpuoFNhIAMISANlQAIQSGSGSsSusSSSSssSTosSsoTTSssoTTooNSTT.......SSNSTSSGLTouASVVSLIDThAWVYQDSSVGIAYLMVSILALFYGQSVSAPPYsDLGIPALPANsSGsGVPQSVQI+AAIsYlNlTI.FIshTGQQFEDLQGPVsTDCGCPNTTSVAPLVhEWEAIhAALpAhAsuoASuNSTosSsSTosoTTsSsSTTTTNSTToTNSTSSSNSoTIAGsIDIuANLTlALQNLQALLhQEuTCAPsLAANAKKSGVR-huPCKsu..uSuCA+SGp+KVKRKARLEKMRAKCRRAVGNR.KGSMKKRVRSRAKKFGKAAKSGVRRYRKNIKaVYIPPVMASLNAYAALMASLS-SIS.QS-SALNSTDpACNSTussTDtAVIsATssVTDMFsNFTAMVlNNTVAaPNCTQaADMAL.MlSQIN-QIIuCGSQSDsApSSIYhNVTIsIVAMAQEYNNFASMSDKCTRSFANSWLWMYIKWVFYRMGMTSGlPNFLACQTKApSSLTAFLASFNATlsATIuAASANsSSVQSSEAuCIESSLuDAAsILtMaEsAYQNCoAPGSV..Ps-T.sTTTTTTTTTTTTTTTAAPTTTTTKAANAPFTYPLCsL.MossCshGhssCTYPhISSAGCCPSGKTLNTGLGGRGCCK.......	0	1	1	1
+6762	PF06934	CTI		Fatty acid cis/trans isomerase (CTI)	Moxon SJ	anon	Pfam-B_14967 (release 10.0)	Family	This family consists of several fatty acid cis/trans isomerase proteins which appear to be found exclusively in bacteria of the orders Vibrionales and Pseudomonadales. Cis/trans isomerase (CTI) catalyses the cis-trans isomerisation of esterified fatty acids in phospholipids, mainly cis-oleic acid (C(16:1,9)) and cis-vaccenic acid (C(18:1,11)), in response to solvents. The CTI protein has been shown to be involved in solvent resistance in Pseudomonas putida [1].	25.00	25.00	26.10	34.10	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	694	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.53	0.70	-13.15	0.70	-6.28	33	247	2009-01-15 18:05:59	2003-08-13 11:44:16	6	2	227	0	54	225	50	647.60	51	88.45	CHANGED	AssPTRLF.lDApssppWRp+GFasVLs...ps.tushpAuLhh+MLpLKpppPLsssshL.s-shDhulsRsppCPs..cEassYtpspPptGMPaGhPuLossEassLtpWLppGA.....shstps.s.ospEtppIspWEsFLNpsuhKppLsARYlYEHLFLAHLYF..........tssp...sscFFcLVRSpTPsGpPlchIuTRRPaDDPGsc...........hYYRLhPlpuoIVcKTHhsYsLssp+LpRhppLFhss-a.pVspLPuYpsphuANPFpoFpsIPscARYpFMLDpApahlhsFIKGPVCRGQlALNVIpD+FWVhFhcP-ps.hsssssahpppsshLtLPupt-ssss.hhs.WhpYuc...ppscYhcs+pphhschh.ts....hshshlWsGs.s.NcNAhLTlFRHFDSASVhKGLlGphPKTsWllDYPLLERIaYhLVAGFDVYGNVuHQL.TRLYMDhLRhEGEsNFLpLLPtcpRcshhssWYpssu.plpp.alpts..hshspPoulpapos.sPKpEhhpplhp.+hsslts.sp.sls...sst..............hppscph...Lsplsuhtus.ulsh...LPE....lohlhl................csssG..cpp.lYSLl+NpAHsNluhLhuEchchpPppDoLTlh.GllGSYPNhhapl.pps-lssFVstlpshcsppD.a.ppll-+aGlRRosPpFWpa.Dplpphh+pspPlEuGlLDhNRaENc	...................................................................................................................AssPTRLa..DApsTppWRptGFaPVLs...ps.tuNhpAulhARhL..KcppPLPtpspL..cshDhSlsR.pppCPo..pEh-patpspPphGMPaGhPsLospEYsTLhpWLppGA......shspth....shospEts.lspaEshLNpsutKppLsARYlYEHLFLuHLYF..............s.tp.ps+FFpLVRSpTPPGp..............PlchIsTRRPaD.DPGs-..........+lYYRLhP.QsTIVcKTHhPasLspp+ltph+phFlssDY.pV.spLPuYpPphuANPhpsFhslPscARapFhLDNAp.hlhuFIKGPVCRGQlALNVIpD+FWVhFhDP-+sph.spsspFhtppsstLpLPupp-sssh.slo.W.l..pYut...ppscYhcA+s-hhsphhtsG....lohshlWcGs...s.NsN.AsLTlFRHFDSASVlpGLlG-sPKTsWlhDYsLLERIHYLLVAGFDVYGNhGHQLhTRhaMDaLRhEGEsNFltLLPtDhRcp.husWYQspu.phptal.pts.shsh-pPTulpa.oc.sPKpELhtpLtc.pltsl.u.sc.sIs...pst.............hhtpsEts...Lpplsphtut...GLhs.......lPp.......lsMLhl................cspp.G....ctp...laTLl+NpAHoNlutLhsEptpt...pPtpDsLTll.GVlGSYPshhhsl.pp.splsphsptltshcs-.pDY..tLl-+aulRRSsPpFWsauDtlppah+pspPlEhGlLDhNRaEN.........	0	11	26	42
+6763	PF06935	DUF1284		Protein of unknown function (DUF1284)	Moxon SJ	anon	Pfam-B_14822 (release 10.0)	Family	This family consists of several hypothetical bacterial and archaeal proteins of around 130 residues in length. The function of this family is unknown, although it is thought that they may be iron-sulphur binding proteins.	25.00	25.00	25.30	26.60	24.00	22.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.83	0.72	-3.85	30	215	2009-01-15 18:05:59	2003-08-13 11:48:14	6	2	214	0	76	160	6	105.20	33	74.01	CHANGED	GYSssFlcNhscIhpcl.t...ppstpIplVsssDcICtsCPsptcst.Cp....sps...pVpchDc....pVlchL...slcsGphhshschhppltcphps.sclcclCpsCcWhphsh	......GYSssFVcNhctIst.+L.....spspsIplVsusD-ICsshsst.s.csp...Cp............s-s......VpthDc......tVhchL......uLc........sGc...hph.s.p.hht.p.h.hcchhs.sslcchCpsCpW.sls.........	0	25	52	62
+6764	PF06936	Selenoprotein_S		Selenoprotein S (SelS)	Moxon SJ	anon	Pfam-B_15061 (release 10.0)	Family	This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types [1]. The function of this family is unknown.	21.30	21.30	21.50	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.48	0.71	-4.76	5	99	2009-01-15 18:05:59	2003-08-13 12:01:14	6	4	75	1	58	110	0	156.90	34	90.36	CHANGED	M-.hcD-sshsNc.lPshEspuL..sFLpsoVGphLSpYGWYLLlGCVllYlLIQ+Lst+h.RulpsRpoptshospDP-pVVRRQEAlEAARhRMQE-LDA+AscFKEKQ+QLEEEKRRQKIEhWDRMQEGKSYK.sSu+lsp-uosEsSoSSul.KPKo...EKKPLRuoGYNPLTGsGGGSCSWRPGRRGPSSGG	..............................h...........................h..sls.hLusYGWYll.hsslllYllhp+.lptc.h...+......shp.p...pp....p..t.s...t..s.s....h-P-sVs++QEAlt....AARh+.MQEELsAp..s..c....ca....+...EK....+phEEEK......R+pcI......chW-shpp..G+u.h+..st.p.....tppss..tsu......suosh.K.K....cp+sL.RsusY..NPLsGp.uGussuaRPs+Rs.sstGG.....................................................	1	25	28	42
+6765	PF06937	EURL		EURL protein	Moxon SJ	anon	Pfam-B_14914 (release 10.0)	Family	This family consists of several animal EURL proteins. EURL is preferentially expressed in chick retinal precursor cells as well as in the anterior epithelial cells of the lens at early stages of development. EURL transcripts are found primarily in the peripheral dorsal retina, i.e., the most undifferentiated part of the dorsal retina. EURL transcripts are also detected in the lens at stage 18 and remain abundant in the proliferating epithelial cells of the lens until at least day 11. The distribution pattern of EURL in the developing retina and lens suggest a role before the events leading to cell determination and differentiation [1].  	22.00	22.00	22.20	23.80	20.60	21.90	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.99	0.70	-4.98	6	69	2009-01-15 18:05:59	2003-08-13 12:32:25	6	2	45	0	39	56	0	244.50	59	93.19	CHANGED	MpEEEQFVsIDLNDDNICSVCKLGTDp-TLSFCHlCFELsIEGVP+SsLLHTKSLRGH+DCFEKaHLIANQDCsRSKhS+SsYEtVKsIlSKKINWIVQYAQNKDlso-oEsSKsoQH.LhsaRHQs-+KLLPQ.DSQVPRYSuKWh.EuNuuuhSshuQplLEp+csp-FsLGhLppssst......LWs.sp.spsQKpEpssSus.sp.QRpasHaSREEL.NpMoltEL+QLstpLLpQIQ-VFEELottVQEKDSLuSELHVRHlAIEQLLKNCSKLPCLQhGRAGhKu	...............................................................................MNEEEQFVNIDLNDDNICSVCKLGTD+ETLSFC.HlCFELNIE...GVPKSsLLHT+SLRGHKDCFEKaHLIANQcCP............RSKLSKST.YEEVKoILSKKINWIVQYAQNKDlDSDSECSK...ssQH.pL...hsFRH+s-cKLLPQFDSQVP+YSAKWl.-GssuulSsps.QpIL...EppcssDFtLuhLpsssus..........LWs.sp.s.psQ+pEcs.us..stsssppp.p.+YSREEL.ssMolsElcQLsscLhpQIQ.-VFE-LsttVQEKDSLuSpLHVRHlAIEQLlKNhSKLP....pLQh.GRs.Gh+....................................................................	0	7	9	19
+6766	PF06938	DUF1285		Protein of unknown function (DUF1285)	Moxon SJ	anon	Pfam-B_15060 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. The structures revealed a conserved core with domain duplication and a superficial similarity for the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain- interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress.	25.00	25.00	32.20	31.20	24.90	24.30	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.93	0.71	-4.23	81	468	2009-01-15 18:05:59	2003-08-13 12:35:09	6	2	462	3	150	424	462	143.40	43	74.16	CHANGED	hcItpDGoWaYpGoPIsR.sLV+LFSolL++-s-....caaLVTPVEKlsIpVEDAPFlAV-hchp.t.puptp.sLpFpTNluDhlhsG.s-HPLRlp...............................hssps..sEs.sPYlpVRss......L-AhlsRslaYcLl-luppps...stshhulhSuGthFs	...hcIptDGoWaY.GoPIsRtsLV+LFo.olL.++-sD.....caaLVTP.VEKlsIcV-DAPFlAV-hchp.s.ps....psp.s.LpFpT.NlsDhlpsss-H.PLRht...............................hpsts.....sp..pPYltVRss......LcAhlsRslaYcLVph.upttc..........pG.thhulhSuGthF......................................................................	0	44	85	116
+6767	PF06939	DUF1286		Protein of unknown function (DUF1286)	Moxon SJ	anon	Pfam-B_15105 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of around 120 residues in length. All members of this family seem to be Sulfolobus species specific. The function of this family is unknown.	25.00	25.00	32.50	45.10	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.83	0.71	-3.90	8	53	2009-01-15 18:05:59	2003-08-13 12:41:15	6	1	24	0	15	48	0	109.80	56	66.48	CHANGED	MKLpTHYVFohGLLTLlsShhh.......sFYhSLllSullSllGNoLIDRLGHpEIpspYGh.IssRTPLTHThPRSlhWGLlsulP.lIhhLtahYGa...........phlhhlLlsGllsGPSHMLL	...........M+L+THYlFSsGLLTLLsShlh.....p.FYhuLllSullSVlGNoLIDRlGH+EItT+YGh.IPVRTPLTHTlPRSVlWGlloslP.hIlLLhaaYGh...........ppllLllLLsGVlVGPSHMLL.	0	4	6	14
+6768	PF06940	DUF1287		Domain of unknown function (DUF1287)	Moxon SJ	anon	Pfam-B_15116 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. This family is related to Pfam:PF00877.	25.00	25.00	38.30	38.20	22.00	19.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.24	0.71	-4.83	25	504	2012-10-10 12:56:15	2003-08-13 12:43:34	6	2	497	0	44	231	32	160.30	69	78.88	CHANGED	llsuAcpplsssltYDsuYhplsYPsGDVPtspGVCTDVVlRAhRp.hslDLQchVHEDM+pNFusYP..+hWGLp+PDsNIDHRRVPNLpsaFpRputsLslotss.......p-YpsGDIVoWtL.sss.LsHIGIVSD+cpssGh.PhllHNIGsGsp..EEDhLFpa....cI...sGHYRa	............IADGARpQIGsTLFYDPAYhpLoYPGGDVPpERGVCSDVVIRALRS.QcVDLQKLVHEDMAKNFApYP..QKWpLKRPDSNIDHRRVPNLETWFoRHsKT.....+PhSKNs.......SDYQAGDIVSWRLDN....G....LAHIGVVSDs.hA..R.D.GT.PLVIHNIGAGAQ...EEDVLFuW....+M...VGHYRY......	0	17	30	38
+6769	PF06941	NT5C		5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	Moxon SJ	anon	Pfam-B_14848 (release 10.0)	Family	This family consists of several 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C (NT5C) proteins. 5'(3')-Deoxyribonucleotidase is a ubiquitous enzyme in mammalian cells whose physiological function is not known [1]. 	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.28	0.71	-4.79	6	770	2012-10-03 04:19:28	2003-08-13 13:06:10	7	7	677	18	215	585	488	168.80	25	85.77	CHANGED	R.lhlhVDhDGVhADFhGthlphasccFtcs..lh.E-hpu.ashcpaG.hpPspt-plapa.hpp.uFFtsLEPlPGAh-sL+clusht.c.VhIsssshh+Y.H..ult-KhpWl-pHhshl.htsllls+-KslVtuDlhIDDpPcNltphps.sh.pILFsssaN+Hlc...sphRssSWp-sachI..lpuKth	.....................................................................p....lslDhDtVLsDh....hst....hl....ch...hs..........at....t..p........l..p.........h.c..t..h....p...s.....h......h...c.t.......................-..ht.....t.h......h..hph...h.cp..s.s..a...F..p.......p...l...c.s...h..P.s.A....E...sl.+cLs.c...p.........h...........l.a.I.so.sshch.p..............sh.p..-........K...h.c..W.Ltc.a....hs........h..........l....s.............p.....c..h...l.....h..........s.....t.........c.......K.......s..........l.........l.........p......u...........D........h....L........IDD..pPcp..h.......t................h..t..s..t.s.......lha.ss......saN..p...p...........h.RlpsW..p-h.t..........ph....................................................................................	0	84	130	168
+6770	PF06942	GlpM		GlpM protein	Moxon SJ	anon	Pfam-B_15323 (release 10.0)	Family	This family consists of several bacterial GlpM membrane proteins. GlpM is a hydrophobic protein containing 109 amino acids. It is thought that GlpM may play a role in alginate biosynthesis in Pseudomonas aeruginosa [1].	25.00	25.00	25.10	27.50	22.20	24.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.27	0.72	-3.79	14	669	2012-10-01 21:19:26	2003-08-13 13:30:26	7	1	664	0	57	200	0	106.30	68	95.42	CHANGED	lKsLlGAhsVLlIulLSKoKsaYIAGLVPLFPTFALIAHYIVGoERuh-sLRsThlFGlaSlIPYhsYLhulYYFohhhpLstsLssAslsWllsAslLlhsWs+hp	....IKAALGALVVLLIGlLuKTKNYYIAGLIPLFPTFALIAHYIVASERGIEALRsTIlFSMWSIIPYFlYLloLWYFoGhMRLPsAhlGuVsCWGlSAWlLIhCWIKhH.........	1	7	19	38
+6771	PF06943	zf-LSD1		LSD1 zinc finger	Moxon SJ	anon	Pfam-B_15249 (release 10.0)	Domain	This family consists of several plant specific LSD1 zinc finger domains. Arabidopsis lsd1 mutants are hyper-responsive to cell death initiators and fail to limit the extent of cell death. Superoxide is a necessary and sufficient signal for cell death propagation. LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. LSD1 protein contains three zinc finger domains, defined by CxxCxRxxLMYxxGASxVxCxxC. It has been suggested that LSD1 defines a zinc finger protein subclass and that LSD1 regulates transcription, via either repression of a pro-death pathway or activation of an anti-death pathway, in response to signals emanating from cells undergoing pathogen-induced hypersensitive cell death [1]. 	20.20	20.20	20.30	20.20	19.70	20.00	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.87	0.72	-6.91	0.72	-4.33	23	365	2009-09-10 17:13:47	2003-08-13 14:14:43	7	6	52	0	186	373	2	25.00	54	21.25	CHANGED	Cs....GCRslLtYPhGAsuVRCuhCpsV	.......Cu....uCRslLhYPhGAs..SV+CulCpsV..	0	32	115	160
+6773	PF06945	DUF1289		Protein of unknown function (DUF1289)	Moxon SJ, Eberhardt R	anon	Pfam-B_15170 (release 10.0)	Family	This family consists of a number of hypothetical bacterial proteins.  The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N-terminus. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	20.20	20.20	20.30	20.50	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.81	0.72	-4.49	164	1514	2009-01-15 18:05:59	2003-08-13 14:58:21	8	8	1024	0	413	1099	1383	49.30	37	55.23	CHANGED	pSPClslCphst.sslChGChRoh-EItpWpphsssc..+ptlhp..plstRtst	.............SPClu..lCph-t.........pshCpGChRot-ElhsWpphocsc..+ptVhp.hhppRh..h..................	0	68	178	296
+6774	PF06946	Phage_holin_5		Phage holin	Moxon SJ	anon	Pfam-B_15309 (release 10.0)	Family	This family consists of several Listeria bacteriophage holin proteins and  related bacterial sequences. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis [1].	22.40	22.40	22.90	22.60	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.13	0.72	-3.82	2	44	2009-09-10 23:38:34	2003-08-13 15:04:36	6	1	41	0	4	35	2	88.70	41	94.32	CHANGED	MEFGKELLVYMTFLVVVTPVFVQAIKKTELlPSKWLPTVSILlGAILGALAT.LDGSGSLATMIWAGALAGAGGTGLFEQFTNRuKKYGcDD.	.............................plLhahohLsllssl..h..VQuIKK.T.cl..lPsKalPsVSlllGslLGAlAs.lss.ss.sLsshlWA...Gu....lAGhuuTGLFEthTp..R..........................	0	1	1	4
+6775	PF06947	DUF1290		Protein of unknown function (DUF1290)	Moxon SJ	anon	Pfam-B_15248 (release 10.0)	Family	This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.	24.40	24.40	39.60	39.60	24.30	24.30	hmmbuild  --amino -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.95	0.72	-4.08	36	498	2009-01-15 18:05:59	2003-08-13 15:07:14	7	1	497	0	137	265	5	88.80	52	78.09	CHANGED	slPstausYLulAllAALDolFGulRAtl-cpFDsclFloGFFuNslLAuhLsaLGDpLGV.s.LahAuVlVFGlRlFsNhAhIRRhLlc	.......lPsshpPYLsIAllAALDAlFGulRAhLccpFcs+VFVsuFhuNVllAALlValGDpLGV..s.L.sAslVVhGlRIFsNsAuIRRhlh.t.......	0	58	106	124
+6777	PF06949	DUF1292		Protein of unknown function (DUF1292)	Moxon SJ	anon	Pfam-B_15310 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	21.30	21.30	21.30	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.77	0.72	-3.63	79	1823	2009-01-15 18:05:59	2003-08-13 15:12:29	6	4	1459	0	278	887	96	76.20	32	73.45	CHANGED	EpGsEhphpllhsh-s.-..s.ppYlllhPht......pp.-p....t...-lhhhph.tp...--s...spttLhsl..EsD.-Ea-hVtcshpshh.sE	.............EpGNEp..ha-llh.sh-s.E.....s.KpYllLhPss..............tp----.............ph...El.shph.ts...--s.....sp...u.cLtsI...EsD..-EW-hlpElasohh-E.......................	0	123	207	245
+6778	PF06950	DUF1293		Protein of unknown function (DUF1293)	Moxon SJ	anon	Pfam-B_15399 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.	25.00	25.00	25.00	36.00	24.50	15.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.31	0.71	-4.19	4	44	2009-01-15 18:05:59	2003-08-13 15:18:40	6	1	39	0	3	27	0	108.10	62	98.04	CHANGED	MA+s.VFVLGIsIhWNstpG-p.ApLNlSRPL+pVNuEKFKRRTlGEsGDVNPpaDQPLhID+cYAh+LE+oGAhVPRREY-lcltlNP-DPLAGuIVsELIPVDsElKKHFpASLK	.........MAp....lhGhsIph.stpG....so.ApLNV.RPlcpVNsEKFtphslG.ssDl.P..cQPLhI-.sYAhhL.cTtAhVPpREYplRht.NP-DPLt.slssELIPhDp-lKKaFptohK..........	0	0	0	1
+6779	PF06951	PLA2G12		Group XII secretory phospholipase A2 precursor (PLA2G12)	Moxon SJ	anon	Pfam-B_15422 (release 10.0)	Family	This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids [1]. 	32.50	32.50	32.90	37.40	28.00	32.30	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.55	0.71	-4.65	8	176	2009-01-15 18:05:59	2003-08-13 15:23:26	6	5	97	0	98	157	1	169.50	40	81.12	CHANGED	sLuL.hL........ssutusc............EscssDWhhsLpoIRsGl+plcsYhsuAL-LlGGcDGlCQYKCpsGps.....PlPRPGY+sP.PNGCGS.hFGl+....hDl.GIPu..MTKCCNQHDhCYDTCGpsKpcCDpcFphCLcsICsDlpKoLGhspsVc.ACEosVchLFsoVhpLGCKPYL-SQRuAClCphEEKsEL	.............................hhhhhhh.................................pt.hsDh..sltslRsuhcplptYhsuhl-Lh.G...G.psGhC.p.Y.+....Cp.......Gpt.....PhP..R....uY+sstPNGCG...S.hhGlp....hsh.GIP..u..hTKCCNpHDhCYDTC........Gs.sKtcCDtcFphCLppIC..s..cl...p+.o..L......G..............hsppVp.......A.C-osschlFssVh.p.LGC+Pa..hsSQ.RsAChCt.E-+t-L...........................	0	25	39	62
+6780	PF06952	PsiA		PsiA protein	Moxon SJ	anon	Pfam-B_15432 (release 10.0)	Family	This family consists of several Enterobacterial PsiA proteins. The function of PsiA is unknown although it is thought that it may affect the generation of an SOS signal in Escherichia coli [1].	25.00	25.00	27.70	27.70	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.62	0.70	-5.30	7	330	2009-01-15 18:05:59	2003-08-13 15:30:40	6	2	215	0	9	171	0	217.40	69	97.79	CHANGED	M.spSpALVsLpstpQAAhpAlhhsEppRcpGspLsuhPas+sFhRlL.sGSuRIssoshRpIsuhhhsscp+hssL.Qh.tALDhLIpStGEhCPLPLohDVtucLFPpVhatcs-RRhp+pslshpRp.RpcuRcsEQphhhhQNLLuQA.sELsFpSPETVsoWYsRWSDc.h-tp-LtshFWpWpsRFsSLsuh-hhphps-PLatVMaEl.hhsREssctlRthERW.VPNKLts	.........MSARSpALVPLSsEQQAAhpAVApTEcRR+QGsTLu..taPYAuAFFRCL.NGSRRISLoDLRFFhPuLTsEEhHGNRL.QWLhAlDhLIEopGEVClLPLPuDAucRLFPSVhFRhpERpR+KosLsh..QKYSRQpsREAEQ+thtYQsLlAQApIELAFHSPETVGSWauRWSDc.Vs.....EHDLETlFWpWspRFPSLuuh-RapWQ-.PhWpVIhEAuhAuR-AsctVRphERWMVPNKLc.p....................................................	0	1	1	6
+6781	PF06953	ArsD		Arsenical resistance operon trans-acting repressor ArsD	Moxon SJ	anon	Pfam-B_15383 (release 10.0)	Domain	This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs [1].	20.70	20.70	20.70	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.58	0.71	-3.95	38	439	2012-10-03 14:45:55	2003-08-13 15:32:12	6	7	386	8	103	319	11	115.90	37	90.33	CHANGED	Mp+..lplFDPAhCCSTGVCGs-VDppLlpFuADlcWl.KppGlplcRaNLuppPhuFscNssVpshLcpuGt-sLPllLVDGpllhsGcYPoRpEL.....spahGlshspstts...........................ssuC.Cuusst....CC	..........................................................MpplplF-PAhCCSTGVCGsplD.tLlphusshphl...+.p..p.........Glp.lpRaNLuppP.tFspNptVpphLpppGt-sLPlhLVDGclshsGpYPopcEl.....ucahulsh.p.........................................sssC....Cu.st.......CC........................................	0	45	72	86
+6782	PF06954	Resistin		Resistin	Moxon SJ	anon	Pfam-B_15476 (release 10.0)	Family	This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes [1].	25.00	25.00	25.30	25.90	23.70	24.80	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.20	0.72	-10.72	0.72	-3.71	11	72	2009-01-15 18:05:59	2003-08-13 16:39:31	6	2	28	12	30	67	0	82.10	54	76.16	CHANGED	ssopCol-pll-cKIK-sLuphp..Pssl.....pKp.LSCsSVpopG+LASCPuGhsVTGCuCGauCGSWDIppcsTCHC.QCu.sl..DWTsARCCpL	..................sto.ssl-phlpcKIp-hhssl......psl........pph.LpCpSVpSpGcLAoCPsGhsVTGCuCG.uCGSWDlR.s.-TTCHC..QCu....sh..DWTsARCC+l...	0	6	6	7
+6783	PF06955	XET_C		Xyloglucan endo-transglycosylase (XET) C-terminus	Vella Briffa B	anon	Pfam-B_20045 (release 10.0)	Family	This family represents the C-terminus (approximately 60 residues) of plant xyloglucan endo-transglycosylase (XET). Xyloglucan is the predominant hemicellulose in the cell walls of most dicotyledons. With cellulose, it forms a network that strengthens the cell wall. XET catalyses the splitting of xyloglucan chains and the linking of the newly generated reducing end to the non-reducing end of another xyloglucan chain, thereby loosening the cell wall [1]. Note that all family members contain the Pfam:PF00722 domain.	20.50	20.50	22.20	21.10	19.20	17.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.04	0.72	-4.26	134	896	2009-01-15 18:05:59	2003-08-13 17:05:34	7	5	108	13	411	924	0	52.80	34	18.85	CHANGED	C................sssssW.hs.pp......Ls..spptpph+WVpppaMlYsYCsDppRaPts..hPs.EC	..............................ttsttW.hs..pp........Ls.sppppphcWVpppaMlYsYCsDpp.R.aPt......s...hPs.EC........	0	61	251	337
+6784	PF06956	RtcR		Regulator of RNA terminal phosphate cyclase	Studholme D	anon	Pfam-B_17814 (release 10.0)	Family	RtcR is a sigma54-dependent enhancer binding protein [1] that activates transcription of the rtcBA operon. The product of the rtcA gene is an RNA 3'-terminal phosphate cyclase [2]. This domain is found at the N terminus of the RtcR sequence. RtcR, and other sigma54-dependent activators, contain Pfam:PF00158 in the central region of the protein sequence.	22.70	22.70	22.80	23.00	21.20	22.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.19	0.71	-4.95	17	470	2009-01-15 18:05:59	2003-08-13 17:23:00	6	3	455	0	52	277	17	182.20	74	34.98	CHANGED	h++pVslGFLGosLD.....tGpuspRWp+WRPoVuLCQp.D.L.lDRLELLH..ss.................RtpsLA-pltpDIspVSPcTEVchp.hplcsPWDFcEVYusLaDFscuYsFDsEpE-YLlHITTGTHVAQIChFLLsEuRalPA+LlQTSPsRc...ptppssGohslIDLDLSRYDpIAsRFspcpp-sluFLKSG	.......................MRKTVAFGFVGTVLD....YAGRGSQRWSKWRPTLCLCQQ.ES.LVIDRLELLH..Ds.................RSRSLFETLKRDIASV.SPETEVVuVEIELHNPWDFEEV...YACLHDFARGYp..FQPEKEDYLIHITTGTHVAQ.ICWFLLAEARYLPARLIQSSPPRK.......KEp.P.+....usG-VTIIDLDLSRYNAIASRFAEERQQTLDFLKSG...............	0	14	22	37
+6785	PF06957	COPI_C		Coatomer (COPI) alpha subunit C-terminus	Vella Briffa B	anon	Pfam-B_20121 (release 10.0)	Family	This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport [1]. Note that many family members also contain the Pfam:PF04053 domain.	19.70	19.70	21.30	20.60	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.43	0.70	-5.94	5	402	2009-01-15 18:05:59	2003-08-13 18:19:08	6	18	285	10	268	405	8	362.60	35	33.49	CHANGED	KGhFEGuLhohuttuAsu+tsh.lss-csA.hs.tshus-DWG.EDsD.lslDt....DuhspucDGLu-s--GE.sc-s-EEGGWDV.E-DLsLPPELDsPK.suGsA-SuhFVsPspGhuVSQpWsNsSsLAuDHlAAGSF-TAMRLLHDQLGVlNFuPaKsLFLcsYAuSRooaRAhusL.Pu..lslaPpRNWSEou.KN..usPAluaKLsQLscRLQuuYQhTTsGKFsEAVEKF+SILlSIPLlVVDoKpEVAEAcQLIsIsREYllGLpMElcRK-LPK-sL-QQKR.sELAAYFTHCcLQPVHhILsLRSAlNlFFKhKNaKTAAoFARRLLELuP+P-VApQsRKVLQACE+NsTDusQLNYDh+NPFVVCGuoYVPIYRG+P-VoCPYCGAsFsPshEGplCTVC-VApIGKDulGLRISPLQsR	.....................................................................................................................................................................................................................................h....s.........p........t....tt...p.....s..........t.tt.....s............t......t.t--...s..u..G.W..Dh.......--.......D..lpls...-.........h...ph....s.t.....................s...s.t......p.s..s.hss....sstG.......s......sp..h...Wsp.N.S.tLssDHltAGuF-oAhpL.LpcQlGllsFtPhK.hFhphatsu+ohh.uhssh.Ps....lh.s.h.pRshp..-s..s....pp.....shPslsh.plsp.Lh.p.c...Lp.t.u.Yph.hssuKhp-AlctF+sILholsll.s.Vcs...cpE..hsEsppllplsREY..llu.Lph..ElcR+p..l..s.......p.....s...sh.......c.......p..........+.....R.hE..LAAYFT+spLQssHhhLsLpsAhshhaKhKNatoA............usFAc...RLL....-.....h...........u.....s......p......s......c.....h.............A.p...p.....sRKlhs.ts.E.+..s..s..p..D..shpl.s......a..D............a......s.......s...F......slCuu.oas...P..I..Y.c......Gp.ss.......hpCPhsGupYp.s.pa+..GplCplsplsplGtss.GL+l...................................................................	1	98	152	226
+6786	PF06958	Pyocin_S		S-type Pyocin	Vella Briffa B	anon	Pfam-B_20020 (release 10.0)	Family	This family represents a conserved region approximately 180 residues long within bacterial S-type pyocins. Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity [1].	22.50	22.50	23.00	22.50	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.85	0.71	-3.82	39	258	2012-10-01 19:36:59	2003-08-14 10:59:20	7	25	167	8	54	270	1	134.20	31	24.52	CHANGED	hpphttstsslshsVRhph...pstsGph..p........lhsl+T..s.tsssspVsVhps.thsppsshap........sssssshslhaoPssss.....tssssosss........................sss.sssshsssslststsp...spshPs.ptt-hcD...hIlsFP..tsSGltPlYlh	...........................phAtstuossh.VRhph...ps.sGp...p........lhul+T..utss.shspV.Vtth.phstpostYc......hh.scs.sss.slhWTPssss.....hpssspTuss........................sss.....hsshhstslsssssp...stshPhs-.c-acD...aIlla.P..hsSGl.PlYlh.................	0	3	12	30
+6787	PF06959	RecQ5		RecQ helicase protein-like 5 (RecQ5)	Vella Briffa B	anon	Pfam-B_20083 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long within eukaryotic RecQ helicase protein-like 5 (RecQ5). The RecQ helicases have been implicated in DNA repair and recombination, and RecQ5 may have an important role in DNA metabolism [1].	25.00	25.00	26.00	26.30	19.60	23.70	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.18	0.70	-4.69	2	54	2009-01-15 18:05:59	2003-08-14 11:51:20	6	4	30	0	22	45	0	185.70	53	21.94	CHANGED	KSCuAtAE.sEPs-YDIPPsSHVYSLKPKRlGAGFsKGsCsFQTATELhtpo+.pcQAPps.htGtpEPPuhsCsL.DEDtScPhPG.ptcs.GuSsphGsPSPEKKsKuSStGS..AKuRASKKQQLLATAA+KDSQsIsRFhCpRsESPsL.ASsPcuEsAsPSCtsV......PtKhT.pEsGAtGH.sAs.QTEt..RERP	..................SCuApucssEPsEYD.IPPASpVYSLKPKRVGAGFPKGSssFQTATELhcpop..p-QAPps..psGcpEPPSpsCsL.DEDpScPLPGPp..sEsPGuSApsGsPSPEKK.......sKuSosGSslAKuRASKKQQLLAsAA+KDSQsIuRFFC.p.R.s.cS.Psh.s.SuPcA.Es.As..PS.Ct.GVpus..hsPEKho.cED.GA..tG+.sAssQTEt..REt..................................	0	1	1	6
+6789	PF06961	DUF1294		Protein of unknown function (DUF1294)	Vella Briffa B	anon	Pfam-B_3405 (release 10.0)	Family	This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.	25.00	25.00	27.20	25.50	24.50	23.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.64	0.72	-4.01	144	1488	2009-01-15 18:05:59	2003-08-14 13:39:17	8	8	1458	0	268	969	50	54.40	44	47.80	CHANGED	sllsFhlYuhDKptAp....cspW........RlsEpoLhlluLl.GGhsGAhlutphhRHKTpKttF	....NllsFhlYuhDKppAc.....+.ptW....................RlPEpsLhlhulh.GGshGAhlutphF+HKTpKhhF.........	0	88	162	221
+6790	PF06962	rRNA_methylase		Putative rRNA methylase	Vella Briffa B	anon	Pfam-B_3461 (release 10.0)	Family	This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	20.70	20.70	20.70	21.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.81	0.71	-4.48	17	1285	2012-10-10 17:06:42	2003-08-14 13:50:07	7	7	1268	14	179	706	33	135.50	43	72.68	CHANGED	+VYuFDIQcpAlppTpp+lcphh...p.....lcLlhsuHEplpcal.p....sl+uulFNLGYLPuuDKpIsTpscoTlpAIpclLsllp.sGlIslVlYaGH-tGchEKcAVhpFsppLsQpcapVhpaphlNQhNsPPhllhIEK	..............pVYuFDIQcpAlcpTpp+Lcptt...h.s.....................spLlhsGHE.s.lc...p...alsc.................lcA...uIFNLGYLP.......u..u..D..Ks.....llT+.PpTT.lpAlppllpl...LshsGhIslllYaGHpsGphE+-AVLcasppL.sQppap.V.hpYphlNQhN.sPPallhIEK.......................	1	74	125	155
+6791	PF06963	FPN1		Ferroportin1 (FPN1)	Vella Briffa B	anon	Pfam-B_3588 (release 10.0)	Family	This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell [1]. This family may represent a number of transmembrane regions in Ferroportin1.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.28	0.70	-6.10	19	342	2012-10-03 03:33:39	2003-08-14 15:26:02	7	7	156	0	257	446	7	355.50	26	83.29	CHANGED	ppslhhLYluHhLusWssRMacFussLalsplassoLLhsuVYuLVcohSslllushlGphlD+.sRl+..slRpsllhQplshslusuhhhhlhhhsp.h...............shlhhslasssslluslspLAssAsolslERDWlVVlu.st.sssLsphNushRpIDLhsclluPllsuhlhuhhShphushhlhshNlsshhlEahhlhpVYptsPtLtcppctppscsptspp...............................tt.t.phthhpphtphhcps.hssWptYhpQsVFLAuhuLuLLYhT.VLSFGshMssaLhpp.GhsshhluhhRususlsGlsGTashPhltp+lGhlRoGlaulhhQhsCLhssVsuhhhssss.................................................................stlsshhLhsGVAhSRlGLWuFDLuVppllQ-...................slsEucRshluusp.uLQslh-LLpashsIhhspPcpFthhshISausl	....................................................................t.....hla.h.uh.huth......ssRhapFuhslh.hhtl.a..s......t...sLh.sulhuhh.shshhhhushlGphlD.p..s.Rht...shph.l....................hhpphshhh.......sshhhhhh..h.h...............................th.hh..h...hhhh.hhhhusltpLsshs.tl....slpRDW.................l...........lsls....t....t........p.....tttL.st.....hNuhh+pl................D.h.splhuPhhhu..lhs...h.........u..........................h............h..shhhh.shshhShhhchhhh.tl.Yp.ss.t....Lt.ptt.t.tt.......................................................................................................hht.th..t....htth......htsa......Yhp.ps.sh.....h.....suhuhu....hLYhT..VL......u...........a.ss.hhssa....hhpp...Ghss.hluhh...huhuulhulh.uThhhshl..p.+h.G..h.l.+sGh....hu.hhhQ.....h.hLhhslh.sh...hh.s..................................................................................hh.sh..hhhh.ul.h.huR..............h.............GLW.aDLsh....tplh...Qp...................tl...tspRshhsuspsuhp.hh-lhthhh..sl.hhspPptFthhhhlSh.hV.........................................................................................	0	80	137	210
+6792	PF06964	Alpha-L-AF_C		Alpha-L-arabinofuranosidase C-terminus	Vella Briffa B	anon	Pfam-B_3625 (release 10.0)	Family	This family represents the C-terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase (EC:3.2.1.55). This catalyses the hydrolysis of nonreducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides [1].	28.50	28.50	28.70	29.00	28.30	28.20	hmmbuild  -o /dev/null --hand HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.15	0.71	-4.50	145	1287	2009-01-15 18:05:59	2003-08-14 16:17:07	7	28	613	70	462	1241	79	201.20	22	33.87	CHANGED	DEWusWh...........................tss..thhtpt.ohcDALstushLssht+puDpV+hAshAQllNlls...............................slhhpss.t.phhhsssYashphaupats.ussLssplpss................................................................................................................................................................................tstsshshl..sssAsh...spsstp....lhltllNh.s.t.tshslplslp...............................Ghps......pssptphL...suss.hpspNoh....ppsppVtPp............pt....p....ssph.shsLPsh......S	............................................................................................................................sEassh.............................ts.....thhtpt.shpsALstushLhsht+p.uD...h...VchAsh..A.Llssls....................................sllhhss..t..phhtssoYashphaupp..ts.upsLssplps.............................................................................................................................................................................................................tthpssshlsss.Ash......spcstp.....lhl...t..l.lNhssp...........shslslslp...............................Ghps......pssptphL...s...u..s..s....hpsp.Noh....ppPpp.........VtPp..............ppth.p.ht..s.sph.phplsshS...........................................	0	167	325	398
+6793	PF06965	Na_H_antiport_1		Na+/H+ antiporter 1	Vella Briffa B	anon	Pfam-B_1828 (release 10.0)	Family	This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH [1].	19.80	19.80	20.50	20.40	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.40	0.70	-5.68	17	2392	2012-10-02 17:06:44	2003-08-14 16:48:31	7	9	1869	3	527	1704	1782	354.40	44	91.60	CHANGED	lpcFlcsEuuGGllLhhuAslAlllANS.sLupsYhuhlcs.htht...h.hsholtpWINDGLMAlFFLllGLElKREhltGpLushppshLPslAAlGGMllPALIYhhlNhssPtshpGWAIPsATDIAFALGVLuLLGpRVPsSLKlFLhuLAIlDDLGAllIIAlFYossLshssLhhAhhslhlLhsLNRhsVppLhsYlllGllLWhslhpSGVHATlAGVhluhhIPhcttpu.....................................p..pSPlc+LEHtL+PWVuFhllPlFAFANAGVSluGhsls.l.ssPlsLGlslGLhlGKslGlFhhualAl+LsLAcLPcGhsWsplhuVulLCGIGFTMSlFIupLAFss....thhs.sKlGlLhGSlhuAllGhhhL	.....................h.pcahpp-ssGGllLlhuullAhlhANS..s...........h.u.t.hY.pshh......c...h..............l......t......h....t............h......s......t........h.t......l......s...hslhh.WINDuLMAlFFhllGLElKRE..lh..p.GpLssh.cpAshPhlAAlGGMllP.....ALlYh..............h..............h..............N...h.......u..s.............s.............................s....h.pGWAIPsATDIAFA.LGlL.u.L.LG.s+lPhuLKlFLhuLAIlDDLGAIllIAlFY...T..s...s...L...u...h.hsLsl.Ahhs....ls..l.L..........h.l............L........N..........h........h........t...........l........p........p........h...hh....Y.l.ll..G.l.l.L.....WhslLcSGVHATLAGVlluhhIPhctp..p.s...........................................................................................puP.....h.c+lEHsL+PaVAalI..lP..lFAFANAGVslp.u.h...s...l.................s.sl......ss.............lsL....GIhhGLhlGKslGIhhh.saLul+ht.l...ApL.PpGhsap.plhululLsGIGFTMSlFIusLAFss........tst..h..hs.huKlGILh..GShhuAllGahhL..................................	1	161	342	452
+6794	PF06966	DUF1295		Protein of unknown function (DUF1295)	Vella Briffa B	anon	Pfam-B_3514 (release 10.0)	Family	This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.79	0.70	-5.07	12	924	2012-10-01 22:51:20	2003-08-14 16:53:11	7	9	605	0	506	2016	1927	217.80	24	75.13	CHANGED	hallsthptpsshlDhhWusshslluhhshhh......stu.hshRphllhhLsslWulRLuhalhhR.shptG..EDhRasphRcphstt.........phhh.hahhQulhlahluLPlhlstustss......sh.tshshlGhslalhGhhhEshuDtQL.sF.................KtsPtN+G+.hhssGLWpaoRHPNYFGEhlhWWulalluhss..hpsh..hslhuPlhhThLLlaVSGlPlhEtph.+phttt.ta+pYpcpT	......................................................................................................................................ahht.h.tp....t.hh.Dhhhuh...s...s.h.hshhh.hhh.......................tts....s.hp.ph...l...l...h.hh..s...hlWuhRLsh...a.hh..h.R...h.......h....t.........s.....-D..Ra........t.....th+..p..p..hs.........................h.thhh..ha..h..hQ..u.....l.h.l..h...h..l.u...l.Ph....h..h....s.........s.........t.....ss...................sh....s..h...h.s....h.l..u..h...s..l.......a...l....h.....G..h...h....h.....E..sl...u.....D......h....Q...h...h.p.F................................................+..p.....s....s...t.....s.............c...........G...........c.....hh..........s.....s.........G.L.W.pa..oRHP....N...YFG......Eh..hh..W...h....u...l......h..l.h.u..h....s.s...................ht......s..........h.........................h..s..l...........h....u...P.l.....h.....h.hh.l...L.h..hh..o...G.hsh.hEp....h..c.ph...............s..tYppYppps..................................................	1	210	340	440
+6795	PF06967	Mo-nitro_C		Mo-dependent nitrogenase C-terminus	Vella Briffa B	anon	Pfam-B_6998 (release 10.0)	Family	This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria [1]. Note that many family members are hypothetical proteins.	19.30	19.30	20.30	47.80	16.70	15.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.92	0.72	-3.83	13	139	2009-01-15 18:05:59	2003-08-14 17:19:46	6	5	53	0	56	140	8	83.00	57	56.74	CHANGED	-lLpPlRpWLDulcIpst+lAHhlC+LIPsQCPFERDlsLFGRhlhHIPPLCKLNPLYEplVuLRFRALsYLADECGEDIopYs	........lLpPlRpWLDsl-lcssclA+h..lC+lIPuQCPFERDIpLFG+plhHIPPLCKLNPLY-plVuLRFRALsYLAD-CGEDlotYh........	0	5	41	56
+6796	PF06968	BATS		Biotin and Thiamin Synthesis associated domain	Finn RD	anon	Pfam-B_5417 (release 10.0)	Domain	Biotin synthase (BioB), EC:2.8.1.6 , catalyses the last step of the biotin biosynthetic pathway.  The reaction consists in the introduction of a sulphur atom into dethiobiotin. BioB functions as a homodimer [1].  Thiamin synthesis if a complex process involving at least six gene products (ThiFSGH, ThiI and ThiJ). Two of the proteins required for the biosynthesis of the thiazole moiety of thiamine (vitamin B(1)) are ThiG and ThiH (this family) and form a heterodimer[2].  Both of these reactions are thought of involve the binding of co-factors, and both function as dimers [1,2]. This domain therefore may be involved in co-factor binding or dimerisation (Finn, RD personal observation).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.92	0.72	-4.14	127	5028	2009-01-15 18:05:59	2003-08-15 13:00:51	8	10	3397	6	1177	3436	382	97.40	30	26.94	CHANGED	slNh..LpPh.pG......os.h.........ts.....t.lssp-hl+hlAhhRlhhPp.stlpluuG+pthhcc.h.s...lshhuuusuhhsGsY..........................hssss.cshscshphlpchG.h......ps	...................PINh....Lhss.pG.....Tsh............ts..spsls.sh-hl+hlA.shR.lhhPp.s.tlRlSuGR.p.hh.cp..hts.....hshhu.uuNu...l...h...hGsh........................................................................Lhosspps.cpDhphlpchGhp................................................................	0	421	778	1014
+6797	PF06969	HemN_C		HemN C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_833 (release 10.0)	Domain	Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX [1], one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparison to other proteins containing a radical SAM domain (Pfam:PF04055) suggest it may be a substrate binding domain.	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.95	0.72	-3.91	87	5381	2012-10-04 14:01:12	2003-08-15 13:44:13	11	4	3710	1	1096	3872	632	66.00	23	16.25	CHANGED	lstp-thpEhlhhsLRh..ptGlshpphppphs.t.....h.t.h.tthlpphtpp..GLl....phss..stlplTppGhh	..........................stc-phcE.hhhsLRh..ppulshsphp.ppa.Ghs..........htphh...tp....lp...p...hhpp......GLl...............p.h.s.s.....stlplTpcGhh.............................	0	314	660	891
+6798	PF06970	RepA_N		Replication initiator protein A (RepA) N-terminus	Vella Briffa B	anon	Pfam-B_1808 (release 10.0)	Family	This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids [1]. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included [2].	30.00	30.00	32.70	31.90	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.60	0.72	-4.19	55	1268	2012-10-04 14:01:12	2003-08-15 15:21:35	6	6	685	0	75	856	25	73.30	38	29.74	CHANGED	ppFaplPKsLhpsppY.cpLSs-AKlhYulLhDRhpLSl........+Ns....WlDcc.GplYhlaosc-Ltp..hLssuc.pKll+lKKEL	..................paaplPK.hLhp.s............pp.a..cplSs-AKlhYulLhDRhpLSh............+Ns......W..lDc-..GplYlla.ospcLhc..hLsp.uc.pKlh+lhcEL.............	0	29	43	58
+6799	PF06971	Put_DNA-bind_N	Put_DNA-bind_C; 	Putative DNA-binding protein N-terminus	Vella Briffa B	anon	Pfam-B_3389 (release 10.0)	Family	This family represents the N-terminus (approximately 50 residues) of a number of putative bacterial DNA-binding proteins.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.25	0.72	-4.20	17	1817	2012-10-04 14:01:12	2003-08-15 15:45:00	8	3	1640	24	349	1010	155	49.40	47	22.82	CHANGED	ppIPcAshKRLPhYaRhLctLhppslcRlSScpLu-tlslsuupIR+DFS	........pIP.c.A.ThKRLPlYYRhlppLps..pG.l.c+lSSpplu-AltlcSAoIRRDFS.	0	159	268	317
+6800	PF06972	DUF1296		Protein of unknown function (DUF1296)	Vella Briffa B, Eberhardt R	anon	Pfam-B_4035 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long within a number of plant proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	21.60	21.60	21.70	26.00	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.06	0.72	-4.01	7	106	2012-10-01 23:03:33	2003-08-15 16:05:18	6	3	19	0	70	100	0	57.30	55	7.87	CHANGED	lPsth+phlQsl+ElVss..S-t-IauhL+EssMDPsEssp+LLpQDsFHEVKSKR-KKKE	....lPsusRKhlQulKEIVss.ho-t-IYAsL+ECsMDPNEssp+LLsQ.D.sFHEVKpKR-KKKE...........	0	13	40	54
+6801	PF06973	DUF1297		Domain of unknown function (DUF1297)	Vella Briffa B	anon	Pfam-B_3819 (release 10.0)	Domain	This family represents the C-terminus (approximately 200 residues) of a number of archaeal proteins of unknown function. One member is annotated as being a possible carboligase enzyme.	23.80	23.80	24.90	31.30	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.09	0.71	-4.98	40	191	2012-10-10 13:17:03	2003-08-15 16:23:52	7	2	111	19	120	188	129	185.00	43	52.81	CHANGED	EapcKhcplhcpGlIspcslcpspIEEYllGshashpaFYSPlpcc........l...EllGlDpRhEoNlDGhhRlPAppQl.ch....slpPpallsGphPsslRESLL.pVF-hG-+aVcAo+clhsPGlIGPFsLQoll...sc-...L-hlVF-lSsRIsGGTNlahs.GSPYStLhascshShGRRIA.......hEI+pAlcpscL-cllT	...............-a.cKhpphhcpGllppcslppshIpEYllGs.h.hpaFYSPlpsc.................l...ElhGhDpRaEoslDGlhR.lPAppQl.cl....plpPpallsGphPsslRESLL.cla-hG-+aVcuscclhs..P.GlIGPFsLpoll......sccL-llVF-lSsRIsuGTNhahs.GSPYShLhascPhShGRRIA.......hEI+pAlcpspL-cllT..............	0	30	60	89
+6802	PF06974	DUF1298		Protein of unknown function (DUF1298)	Vella Briffa B	anon	Pfam-B_4362 (release 10.0)	Family	This family represents the C-terminus (approximately 170 residues) of a number of hypothetical plant proteins of unknown function.	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.68	0.71	-4.42	14	691	2009-01-15 18:05:59	2003-08-15 16:32:11	8	13	255	0	271	581	59	145.90	22	32.32	CHANGED	KsSKCR..WGNahGhlllPFsl.uLcsDPL-Yl+pAKuhhDRKKpShEAhhoYhhh+hllKhFGhKsusslhpRhhsNTThsaSNllGPsEEISFhGHPIsYlAsSsYGpPpALsIHa.SYssKhhIsluVDsslIPDPH+LCDDhEESL+hhKsA	............................................................................s.........GN.hu..h..h..h..h..s.h......h....t......s...sP....l.phlpt.......h..p..t..th...p...t......t.+...p.....p...h...p......t......h.........h...h..........h.....t....h...h....h....h..h...h...u.......t...h...h....t....t...l.....h....t...t...h...............s......h........s.l..s...lSNV.PGPp-.....lhhsG.u......l..s..t..h.hs...s.s.h.s..t.s.p...........u....L..sl..olh..SYssp.lshulhssp..ssls...-spclssthtcuhppl....................	1	71	176	236
+6803	PF06975	DUF1299		Protein of unknown function (DUF1299)	Vella Briffa B	anon	Pfam-B_3488 (release 10.0)	Family	This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that many family members contain multiple copies of this region.	25.00	25.00	45.20	45.20	19.90	17.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.39	0.72	-4.10	4	21	2009-01-15 18:05:59	2003-08-15 16:40:27	6	4	1	0	0	21	0	46.50	84	17.30	CHANGED	HDEas-stDQEAYlILSDDEsNGTAPTEKESQPpKEETTEVPKEEsV	HDEHDETEDQEAYVILSDDEDNGTAPTEKESQPQKEETTEVP+Epph	0	0	0	0
+6805	PF06977	SdiA-regulated		SdiA-regulated	Vella Briffa B	anon	Pfam-B_2520 (release 10.0)	Family	This family represents a conserved region approximately within a number of hypothetical bacterial proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators [1]. Some family members contain the Pfam:PF01436 repeat.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.59	0.70	-5.43	24	899	2012-10-05 17:30:42	2003-08-15 17:25:23	6	9	524	1	91	519	74	223.90	40	78.35	CHANGED	stulhLssY+ssl-.u+slsGlccs.lSuLTYsPppcoLFuVsNp.sspLlELShcG-lLR+lPLtG.FsDsEulpalusGphslsDERpppLhhlplsspTpslshs-...hpphsLGhs..tssNKGFEGlAaDstspRLhluKERsPhtlaclpu.......ss.sltsssptsh.t..pplhl+D...LSuLpaDtpoGHLLlLSDESRhllElD.tpGc.lShhoLhtGhsGLccslPQAEGlAhDccGsLYlVSE.PNLFYhFc	..............................................................................................................................................................................p.sh.hpsYcssls.tK.lsGlps.s.lSuLTass....pspp.LFushNp..P.........u..........t..l..V..ch....o.p.p.G.c.l........l.+p.hP.L........sh........h.........p........DhEsIEa.l.GsN.p...as.l.u.....-..ER..c.......h.....t..lhhhpl......................o.......t..s..p..l...t.......hh.cl.p.lshp....pspNpGFEGLAastpscpha.h.h......K..E...+.....pP.....lp....lhcspt.................................ssspLphucstslp........tthplp.D.......l......SGhp..a..s.tp.pspLllL.ScES+hl..hEls..pGc.hls.....hsLs+G..p..GLpc..sI.Q.uEGIAhD.s.p.s.slYIVS.E.PN.hFY+Fo..........................................................	0	20	42	75
+6806	PF06978	POP1		Ribonucleases P/MRP protein subunit POP1	Vella Briffa B	anon	Pfam-B_7848 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5) [1]. These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.	22.20	22.20	24.00	24.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.44	0.71	-4.63	38	354	2009-01-15 18:05:59	2003-08-18 13:52:12	6	10	265	0	265	358	4	151.60	31	21.10	CHANGED	FlpuRphEIcslppuhppuKtstsoRsFQplPRpLRRRsASHNl+RlP+RLRsRAt+EMhpsss.....................ttphhh+hcst++l.ph.tp...............................................................................................ltp.s.spt+ap+RQcp......p..pWL.THlWHAKRh+Msc...............hWGaplPh..sPTpKsaRssaR.....tspcsslsaDhSYhss....ltlpGs	...............................................................................................................................................................................................................................................FhtuRthElpth.tuhpppp................sp..hsF.Qp..lPRphRRRshSHNs+RlP+.RhRthshpch.pstt.......................................h.p.c.ttt.................................................................................................................................................................................ht...p....ca..t+Rp.pp........p....hWL.THlWHAKRh+Mhc...............hWGatls...ps..stKsaRssaR..................t.pptslh.DhSYhssltlps.t.....................................................................................................................................	0	104	157	222
+6807	PF06979	DUF1301		Protein of unknown function (DUF1301)	Vella Briffa B	anon	Pfam-B_8295 (release 10.0)	Family	This family contains a number of eukaryotic proteins of unknown function that are approximately 160 residues long.	21.70	21.70	23.90	23.70	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.76	0.71	-4.01	7	128	2009-01-15 18:05:59	2003-08-18 14:35:39	7	4	104	0	91	127	1	128.50	34	59.20	CHANGED	uVKhFShSTSlsulsh.P.lLLcpuhthsu..hshtlhhhGlhGFFTFlTPlLLHhlTKtYVhcLaa-ssp-pYTAsThshhLpcppThF+.cDVslP-lsthFToFhscsKuLhVsPsLFPsPpcY.+lMGYDK	.......................................VKhFShSTShhulshhPhl...hhpss..ths.u....lsh..p.shhsuh.luhFohh...TPhlLH.alT..KsYVh+L..aa.p...ss............o.D..........oYpAhThs.hlhpcppp...........sF+.sDV....p....lP.-.....ss.+hF...TTFhAcs+shhVssthF.ss.pca.+lMGY-............................	1	28	43	70
+6808	PF06980	DUF1302		Protein of unknown function (DUF1302)	Vella Briffa B	anon	Pfam-B_7023 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.	19.90	19.90	20.70	20.10	19.50	19.70	hmmbuild  --amino -o /dev/null HMM SEED	554	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.66	0.70	-5.94	64	345	2012-10-03 17:14:37	2003-08-18 15:53:48	6	3	208	0	139	351	210	566.70	31	94.05	CHANGED	hsFshG.-...lpssaDoolShGsuhRspstspshh...........................................tssstssssDDGsLNac+.G-shSphlKuhp-LpL+assh.......GhFlRGphaYDhthp-sstp....................................s.ss.pscpttspsscLLDAaVatsasl..GcpP.sslRlGcQVlsWGEShF...ltsG...I.NshNPlDls.thptPGuElKEsllPsshl.suhuLocsLSlEuaYQ..acWcpotlsssGTaFSssD.hhucGsps..h............................h.hhss.ss.sh...............................shhh.css-tcuccsGQaGlslRahsttL..-TEaGhYahNYHs+hPhlussssshsshs......................................................................spYhhpY.sEDIcLaGhSFsTslG......ssuluGElSYRsstPl.tlsssplh...........huuhssts...................................shss...Gt.hp.......G...Ytct-shQhploslphhst..........shGAspholluEluhsalhul...ststhphs.t.ssht..............................................t..tstspshsTpsuaGY+lthphsYsslas.GlsLsPslsauHDlpG..hoPs...sssF.sEGp+ululGlshsYp...spapsslsYssFaG.............Gshs......................shsDRDaluholshoF	............................................................................pFshG..-...lpupaDoolohGsuhRspstspsll................................ststs.stssDDGslNFc+..G-shSphhKulp-LcLpatsh.......GhFlRGphaYDhthpDpspp.....................................hhs...s.ss.ppct.hpupsscLLDAFVatsasl..GstP.hslRlGcQVlsWGEShF...hts...G...I.suhNPlDls...thptPG.uEl.KEsl.................lPlshl.huhsLT-sLSlE...uaYQ..hcWcpohlsssGTaFSssD.....hh.u.cGspthhh................................................hss..tt......................................shhh.c..us-p.cscc..u..GQaGlsl+ahsptL..-TEaGhYahNYHu+..tPh...luspsushsshs..s..................t................................................................spahhpY.PED.I+LaGhSFsT..s..lu......ss.uluGElSYR.stPl.tlssspll...............hushssts...........t........................ss.s.........GtthpGahRt-shQhphohh.phas...........shGA-pholluEluhs+ltsl...shsphphs..tsss.ht........s..s........................................shsp..tspssshsTpsuaGYclthphsYssVas.GlslpPslsau+DlpG.hoPs.....h.ssF...tEGpKulolGlshsYp...spapsslsYssFaG.......uphs...................................shsDRDaluhohphsF................................	0	33	60	105
+6811	PF06983	3-dmu-9_3-mt		3-demethylubiquinone-9 3-methyltransferase	Vella Briffa B	anon	Pfam-B_6583 (release 10.0)	Family	This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases (EC:2.1.1.64). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.46	0.71	-3.75	25	2984	2012-10-02 15:00:03	2003-08-18 16:55:30	8	7	1713	10	686	1992	166	128.00	27	87.56	CHANGED	sKIossLWF...D.spAEEAspFYsSlFsNScltslschspst.su.....tGsVhsspFslsGpsFhuLNGG..PpFpFscAlSFhlsCcsQcElD+hWstLstsGu........ppu.tCGWl+D+aGlSWQll	..........................................................sPaLhF....s....up...ucEAhsaYpp.....s.F.............s........s........u.....p..l.....h.....p.h.......p........p....h......s....p......s.....t.....st................ps.....p.....l...h.....au.....p......h......p.l..s.G.p...s...h..h....s............D.......u..s............s.s...h.....p.......h..........s.......s....u.......h.....S.......l....h...l..s..............s.........c..........s..p.....p.....E......s....c......c...h...aspLsssGpl.h.............pthhts.taG.hlpD+FGlsW.l..........................	0	219	460	593
+6812	PF06984	MRP-L47		Mitochondrial 39-S ribosomal protein L47 (MRP-L47)	Vella Briffa B	anon	Pfam-B_6890 (release 10.0)	Family	This family represents the N-terminal region (approximately 8 residues) of the eukaryotic mitochondrial 39-S ribosomal protein L47 (MRP-L47). Mitochondrial ribosomal proteins (MRPs) are the counterparts of the cytoplasmic ribosomal proteins, in that they fulfil similar functions in protein biosynthesis. However, they are distinct in number, features and primary structure [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.02	0.72	-4.08	8	327	2012-10-02 11:59:50	2003-08-18 17:11:16	8	5	288	0	229	380	11	87.70	41	34.85	CHANGED	LhEFF-s.....c+sh..sEpc.s.KsG...+uWssppLRpKShsDLHpLWYshLKE+NMLhThcpchpcpphs...hPuPERlcKV+pSMcslcpVlpER	.....................................L.pFFss.............pps.h....s.p..p.c...sp.tG.......RuWss.pELRtKSh-DLHpLWaVhLKE.RNhLhTh...cpctp...+ppht..............hss.s-.R.h....c.+...Vc.........poMppIcpVlpER......................	0	77	126	190
+6813	PF06985	HET		Heterokaryon incompatibility protein (HET)	Vella Briffa B	anon	Pfam-B_8200 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins that seem to be restricted to ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two different wild-type strains [1]. Many family members also contain the Pfam:PF00400 repeat and the  Pfam:PF05729 domain.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.32	0.71	-4.02	164	2623	2009-09-13 05:28:11	2003-08-19 10:54:52	6	149	90	0	2311	2726	2	139.30	21	21.73	CHANGED	YtsLSYsW....Gsst.........................tttl......................hplsps.lpsAlphs.+.p.........h.....uh.cY.....lWlDslCIsQ....s.ss......-hspplspMtplYppAthslshhusss.............................pt.....................h.shp.h.....pthtt.tht.............................................................................t..hhpp....ltp......s.WasRuWslQE	.....................................................................YhsLSasW.........Gssp................................................................................p...t.h...h..t...........................h.t.l...s...p....s.......l.p.s.Alphh...+.p...............h..............sh..ca..............................lWlDs......l...C.I....s.Q................s....st.............t.......-.........hs.ppls.t...M.tp..lYpp......Athsls.hhu..sss................................................................s..tt...................hh.p...............t..............................................................................................................................................t............h..p.......t..h..h....pRhWshQE.................................................................................................................	1	357	1215	1922
+6814	PF06986	TraN		Type-1V conjugative transfer system mating pair stabilisation	Vella Briffa B	anon	Pfam-B_8400 (release 10.0)	Family	TraN is a large cysteine-rich outer membrane protein involved in the mating-pair stabilisation (adhesin) component of the F-type conjugative plasmid transfer system. TraN is believed to interact with the core type IV secretion system apparatus through the TraV protein [1][2][3].	21.60	17.10	23.00	17.90	20.30	16.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.24	0.70	-5.02	17	647	2009-01-15 18:05:59	2003-08-19 13:20:02	6	8	342	0	93	486	42	199.50	26	41.21	CHANGED	stCphspc.pCh...Essts+h..lsGlsl...........sh..sCWctptsYpCss...............................ss..TCstlpsp.......sCphspppCh.p...pptuhChptphsapC.pps..ssss...phhCusssaClsGsChpsppctss..-FscusutLuAlspAsp-hsss..........shplFpGputpCp+thhG.hssCCss.pGaG......slu...............ltp...CsstEcsLuptcppshsh.lGoYC..ucK..llusChp+KcsYCsFpSKLu+llQpQG+p.QLGhuaGosKpssCpu............lTs	.........................................................................h.................................h...............................th.....Ch.t..p..p..h.s.......................................s..sCt.h.tp.......tCt..h..p.ppCh.................tttu.Chh...hYp...Ct.p..............tt........p......t.....s.ss..t..t.....t.............pt..thtp.hs.hthh.t.ht...thts.................h.hFtGp...........C..p.h.....h..h.s....h........sCCpp..tsh.s.........t........................................................................lht.....CsppEhtlsttc.tt....ph.sh.lGpaC.sp+.....hlu...sCl.pc..+cs.aCpFpSpLupIlppps+......Q....L....t....h.....s....aGss.p....ps....pCpuho.s.................................................................................	0	21	47	72
+6816	PF06988	NifT		NifT/FixU protein	Moxon SJ	anon	Pfam-B_5696 (release 10.0)	Family	This family consists of several NifT and FixU bacterial proteins. The function of NifT is unknown although it is thought that the protein may be involved in biosynthesis of the FeMo cofactor of nitrogenase although perturbation of nifT expression in K. pneumoniae has only a limited effect on nitrogen fixation [1].	20.80	20.80	20.90	21.90	19.80	17.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.03	0.72	-4.50	36	178	2009-01-15 18:05:59	2003-08-19 13:33:27	6	3	167	1	86	157	12	63.60	47	82.34	CHANGED	M.KVMlRcssp.ssLssYVPKKDLEEslVsh-..pschWGGhlsLuNGW..pLtlPshsssspLPlTV-A	M.KVMlR+sss..sLosYVPKKDLEEslVp.hE..psshWGGhlpLuNGW..pLtlPphsscspLPlTl-A...	1	22	52	68
+6817	PF06989	BAALC_N		BAALC N-terminus	Moxon SJ	anon	Pfam-B_5793 (release 10.0)	Family	This family represents the N-terminal region of the mammalian BAALC proteins.\	 BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organisms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumours or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms.  Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions [1].	25.00	25.00	51.00	51.00	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.52	0.72	-3.64	2	32	2009-01-15 18:05:59	2003-08-19 13:40:07	7	1	21	0	15	28	0	51.80	76	40.27	CHANGED	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDA.PSsAAsDSGPEAGGLpA	MGCGGSRADA.IEPRYYESWTRETESTWLThTDSDuP..PSu.A..As.........DSGsEAGG.................	0	1	3	7
+6818	PF06990	Gal-3-0_sulfotr		Galactose-3-O-sulfotransferase 	Moxon SJ	anon	Pfam-B_6301 (release 10.0)	Family	This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans [1].	20.20	20.20	20.20	20.30	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.61	0.70	-5.81	3	598	2012-10-05 12:31:09	2003-08-19 13:49:40	6	17	61	0	434	689	22	279.80	24	77.98	CHANGED	MhPhLttLQ+ts+hhht+tLlLslLhhooFLLLlaphA..shHucLt.sTP.FuuSCsP.t..............EuPPRsN...IsFLKTHKTASSTVLNILFRFAE+HNLoVALP.sGsRscFsYPphFuA+aVc.....ussupp.FNIlCNHLRFchsEVc+LMPssTlYlTILR-PAthFESSFpYYssYsPAFR+lPuus.L-AFLpuP-sYYcsucH.pAhYA+NsLaFDLGhDN-hsPps-puYVpu+ItEVERRF+LVLIAEYFDESLVLLRRLLsW-LDDVLYFKLNARuASsVuRLSuEstu...RARoWNALDu+LY-HFNATFWR+V.AchGRcRlcREVccLRcARcRLtolClsDGsAL+sAAQIRDcpLQPWQPSGKsDILGYNL+sGluspssplCpRLlMPElQYhscLhApQ	.............................................................................................................................................................................................................................................................................................................................................................................s....h..pp.........lhFl..KoH.KouooT..l..sl....l.h.R..............au..p..cpL.ph..s.........hP.....t.......t.........t..h....t.a.......P............h..t..t.p....h...l..........................t.............as...l....h.s.p......H..h..........c.......a..p..........h...t..t...l.t.pl.h....s.s..s....s...h...........a.hoIl....Rc.Ph.t........hcS.F..t..a..a.........t............................................h...........h....h............t........h..................s.......................ltt....F..l..p.....p..P.............t....a....h......p..............t......t.....................t...........h.........h........h...+......N.......h.....h....a....D.h.G...............................................t........t.............t................h.p......t...h.lt.tlp.p....tFpLVhlhEaa-ESl..lLL+chhs...W......phcDll........h...h....t.......h....s...................p....t............t...p..............................t.......h..s........t...t..................ph..p...tas.h...Dhh...LYpaFNt.........ohWp+l...tt......G...t......h.tpht....hpth.tt..h..t.C.......................................................................................................................................................................	0	290	302	342
+6819	PF06991	Prp19_bind	MFAP1_C;	Splicing factor, Prp19-binding domain	Vella Briffa B	anon	Pfam-B_8343 (release 10.0)	Family	This family represents the C-terminus (approximately 300 residues) of proteins that are involved as binding partners for Prp19 as part of the nuclear pore complex.\	   The family in Drosophila is necessary for pre-mRNA splicing, and the human protein has been found in purifications of the spliceosome. In the past this family was thought, erroneously, to be associated with microfibrillin.	20.90	20.90	21.50	21.30	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.94	0.70	-5.12	5	330	2009-01-15 18:05:59	2003-08-19 13:57:47	6	8	269	\N	245	315	2	231.40	35	59.81	CHANGED	EtElhptE-EccupEEEEE.ESEpEE-TDSEDDME.....PRLKPlFlRK+DRs...TlQE.+E+EttKpctL.EtEAKRtAEERK+pTtKIVEEslKKELEtcKs......p.cAsls..sV-TDDE.N-ppEYEAWKLRELKRlKRDREEREshEREKtEIE+hRNMTEEERRspLRpNPKVlTNKssKGKYKFLQKYYHRGAFFh.DE--E........VhKRDFSpATtED+FDKTILPKVMQVKN..FGRuGRTKYTHLV-EDTTcasSsWsusss.NpKF...s++AGGhRssF-+PsuKKR	..........................................................tct.p...p..tp..p.p.-p...psp..E..p.......o..-sE--...................hl.+P.lFl.pKppR.............o.htp...ppt.t.........c..p...pp.h...c.t..p....t....c...c.h....h.cp..R..+...p.s.p.....llc-ph.c+-httppt................t.........ss........hp......sss.T.Ds....ssc........t.........EYpAWKlRELcR...l.KR-R-..t.......h.-..th-+E+tElERhRshT-..EERpt.......-.......c..t..t..s.c..............p..p.c...t.....KG...Kh.....tFh.QKYaH+..GAFa...Dp.tc.p..........l.h+R..D...hs.s.s.p.h.-Dp.h.s+phLPchhQV+s...hG+pGR.T.KYpcLhspDTs.....pa..s......s.....h........................................................................................	1	81	132	197
+6820	PF06992	Phage_lambda_P		Replication protein P	Moxon SJ	anon	Pfam-B_6611 (release 10.0)	Family	This family consists of several Bacteriophage lambda replication protein P like proteins. The bacteriophage lambda P protein promoters replication of the phage chromosome by recruiting a key component of the cellular replication machinery to the viral origin. Specifically, P protein delivers one or more molecules of Escherichia coli DnaB helicase to a nucleoprotein structure formed by the lambda O initiator at the lambda replication origin [1]. 	21.10	21.10	21.10	21.50	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.42	0.70	-5.08	2	541	2009-01-15 18:05:59	2003-08-19 13:59:08	6	2	340	0	27	376	18	200.50	54	94.62	CHANGED	MKNIAAQMVNFDREQMRRIsNNMPEQYDEKPQVQQVAQIINGVFSQLLATFPASLANRDQNElNEIRRQWVLAFRENGIToMEQVNAGMRVARRQNRPFLPSPGQFVAWCREEASVhAGLPNVSELVDMVYEYCRKRGLYPDAESYPWKSNAHYWLVTNLYQNMRANALTDAELRRKAADELspMTARINRGEsIPEPVKQLPVMGGRPLNRsQALAKIAEIKAKFGLKGASV	....................................MKNIAAQMlNFDpEQMRRIANshPEQY.D-.+s...QV..p.Q.V....A..p.IINuVFSQLhAsFPA.S.l..AN..R-.QsE.l.NE..l..RRQWVLAFpENGITTMEQVsAGMRVA..RRQ..sRPFLPSPGQFVAWC+E-Au.V.hsGLPsluELlDMlaE...YCR+RG...L...Y.P.Du.E.sYPW..........+S.NA.aYWLVTNLYp.sMRAsuLTDuELRR+AuDELspMss.RIsRG...EsI.P.EPV.KQLP.shu.s.RPl..spsp.AL.u+IAEl+AKhGLKGu.........................................................................................................	0	3	8	15
+6821	PF06993	DUF1304		Protein of unknown function (DUF1304)	Moxon SJ	anon	Pfam-B_7246 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	23.80	23.80	25.20	25.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.63	0.71	-4.36	73	1298	2012-10-01 21:33:42	2003-08-19 14:01:57	7	7	1246	0	231	804	18	108.50	39	89.68	CHANGED	ssLVAl.hHlYIhhLEhFhaspstst+.sFshs..-hhptsps..LutNQGlYNGFLAsGLlhGlhhsss......shtlhhhhLhsVllAulaGuhTu.s+.+I........hhlQulPAllALlhlhl	..................hlVAl.EHhYIhhLEhhthsS..ct.ss+.sF.shsh.-phpppslp.LhtNQGlYNGhLulhL...lau...l..ahups..........hplshhhllhllsAAlYGul.Tu..s+..pI..........lhpQGh.sAlLALlull................................	0	65	139	189
+6822	PF06994	Involucrin2		Involucrin	Vella Briffa B	anon	Pfam-B_8443 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialised protective barrier) of stratified squamous epithelia [1]. Members of this family seem to be restricted to mammals.	20.90	20.90	25.30	20.90	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.13	0.72	-4.00	38	508	2009-01-15 18:05:59	2003-08-19 14:22:41	6	23	16	0	38	498	0	41.10	53	104.60	CHANGED	Q-..spE.ELHLG+QQp.......csQE.....E..LaLGc..p.pQcspE.ELH..LGc	....................QE..s.EPELpLGKQQp......Qcs..E....PE..LpLGK..QQQQEspEPELpLsc.....	0	0	0	0
+6823	PF06995	Phage_P2_GpU		Phage P2 GpU	Moxon SJ	anon	Pfam-B_7670 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 130 residues in length which seem to be related to the bacteriophage P2 GpU protein (Swiss:O64315) which is thought to be involved in tail assembly [1].	25.00	25.00	25.00	25.00	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.26	0.71	-4.72	55	1047	2009-01-15 18:05:59	2003-08-19 14:26:17	6	5	735	0	148	714	14	118.70	37	69.33	CHANGED	G.FhFsl.pTssapphpRptsaRasspsRlGt+PuhQalGsup-pIoLsGllaPchpG........GthsLptL+thAspGpshsLlpG...sG.pl.hGhaVIpsls-TpohahssGssR+l-FolsLc+hs-s	..............................GhaVFtl...pT...lsa..QplppppsaRassssRlsc+..su.hQalGssp-pIsLuGlL..hP.El.s.G...........G.choLp.tLcphAc.pG.+u.asLl...-.....G.....sG...pI...aG..h..aVIpslspTp.opFhtsGts++I-FoLoLcRsD-................	0	28	71	113
+6824	PF06996	DUF1305		Protein of unknown function (DUF1305)	Moxon SJ	anon	Pfam-B_9388 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 300 residues in length. The function of this family is unknown although one member (Swiss:Q93IT4) from Salmonella enterica is thought to be involved in virulence [1].	20.30	20.30	20.60	20.30	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.71	0.70	-5.39	121	1497	2009-09-11 01:13:09	2003-08-19 14:44:15	6	5	955	0	274	1048	48	297.70	28	87.63	CHANGED	h...tpstpa...sFaphl+.ll-..............p..htspt....s......hG....psttstp-slRhpspsuLuFssu-l...ssl.....................tt..psss....hp..lpsshhGLhGssu..PLP.haaoEhl..hpR.............ppp-sshtsFlDlFpHRhhsLaYRuWpchphs.sshcp..ss.........s.......-tasphLhuLsG.......hu...t...........htt.............................................ptshs......sst.hLtauGhlsppsRospuLp....slLsphFs..ssVplcpahspWlplstsppspLG............tt...sspLGtsshlGpclhDtpu+hclpluPlshppatpaLP...........sG.p.....thtp.....LtpllchalGtphsa-lpLhlptcplssspL..Gsst......pLGhsuaLup	..........................................................................................t..pshpasFaphhc.hLc................p....htstp...............hu..tttpstp-tlRhpsssuluFsss-ltsl.................................................tp...pssst.........hclpstahGLhGspuPLP..ha.YhEhl..hp+.............tcpcsshtsFhDlFsHRhhshha+sWpchp.hh.hsacp....ss............p..................-tauthlhuLsG.......ls..tp......pt.....................................................ch.sls........ppt...hLuauuhLspt..sR..oscslp....slluphF......s...sslpl..ppahh+hlslssspp..spLG............tt...sshL.GtssllGpplhDhps+hplplssLshppahpFLP................sG.p........ph.s..Ltthlchals.phsa-lpL.tl.t..pp..ss.s.hpL..........Gssp................pLGaouaLG..........................	0	44	112	192
+6826	PF06998	DUF1307		Protein of unknown function (DUF1307)	Moxon SJ	anon	Pfam-B_10058 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. Some family members are described as putative lipoproteins but the function of the family is unknown.	21.70	21.70	21.70	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.56	0.71	-4.08	14	1049	2009-01-15 18:05:59	2003-08-19 15:49:10	6	3	820	1	25	350	1	121.10	40	78.69	CHANGED	EocTY..pus.hsGh.clplTYoY.KG.DcVlKQoscsplpYssLGlspcEt.....A.....cchlps.scpYpslcGlp.clcYpDctshEplslDYpKsDhccl.ppLsGht.s...s.csuKsIShccotchLcppGaKc	...................................................................EoKpa...sus.ls.Gp.-ltlT..YsY..KG.DKVLKQoocspIp.Y..ssl.G.ssscEp........A...........tKhLc.s..l...us...p.Y.KsI..tG..VccKlsYp.Ds..h..A..E.plsIDhpKlDhcsL......ptluGh...phs.......s..cssK..sI....SMtph.ppllctsGaKE..........................	0	7	9	18
+6827	PF06999	Suc_Fer-like		Sucrase/ferredoxin-like	Vella Briffa B	anon	Pfam-B_8856 (release 10.0)	Family	This family contains a number of bacterial and eukaryotic proteins approximately 400 residues long that resemble ferredoxin and appear to have sucrolytic activity [1].	29.50	29.50	29.50	29.70	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.82	0.70	-4.34	28	603	2009-09-13 18:23:08	2003-08-19 16:01:51	7	12	371	0	360	589	30	219.30	22	64.87	CHANGED	sLhGTupshppalllpp.........stsWsp..pt..tt.......slhpt......lsshlppptpshthth.lshpsscps................tspssp................................lllhsthlhht.....hcthpp-hltslLshshs.......................t...th..httspc..ps.hlhVCoHusRD+pCulhG.slhpchcpphsspsh.p...................................Vh.sSHlGGH+FAssllla..................spGhaaG+lsPcplssllcp....hscsphlhchhRGht	.......................................................................................................................L.Gssts.htpal.lltp...........tsWsp....chhptp..........th.tt........................lt.t.h.hp.t..t.h.t...t.h..t.........t.h...hhh...psst.....................................................t.t.p...sp...............................................................................................................shlhsthhhh..h..........htt.h....p.h.h..p.t.hls..hsht.............................................................................t.............t.stt...psshlLlCoHup....R..D....t+..CGl.t.G.s..ltpphpcpltt....t....sh...........................................................................................lh.sSHlG...GH+aAuNllla................................................................................spGhaaG+lpP...c.s.sp.sllct..........hhpG.cl..l......hhRG..............................................	0	98	225	312
+6828	PF07000	DUF1308		Protein of unknown function (DUF1308)	Moxon SJ	anon	Pfam-B_13288 (release 10.0)	Family	This family consists of several hypothetical eukaryotic sequences of around 400 residues in length. The function of this family is unknown.	25.00	25.00	26.30	25.60	19.30	24.50	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.13	0.70	-5.81	24	258	2009-01-15 18:05:59	2003-08-19 16:33:44	6	6	206	0	175	260	1	339.80	24	77.84	CHANGED	+LpsplpuEL+hLp+lpsthssh.....................................................h.pplpSoNLsaaculhpthcp.ppslsult+sF......................shpc.sts.........plhVDlVussGpp..WVKV.stsscpLhhphttps..............................p.sshsllc.ApshlpAupts.sta+p.Pclhhlh........................................hss..ssl.hcpl+phG.....lsl...............................hhtstststss.....h.......tsshtph.s........s..htshssplNlDsTsLlAhVSslSa.sssph.............hpc+hltcQhchE.+pcPlLsp.L.sthcu+cL.........................................................................................................................lsscpAscchp-Il-TlGGssE+pRuppLhtpl.hl.s.....................................Pst...phppLht.ttlphpslplFuhssthchshhTsNtth.lcuApppGhhhsVhp+ss+sLo	.......................................................................................................................................h.p.lttEhp.Lpph.t....................................................tth.oo...Nhsahpslhp....hpp...........pslsul.p.F................................................thtt..............tlhVDlVs..s..sG..tp..WlKshshps.ctLh...hhtpu............................................................p.s..phs.llcpApchlpAup........tp....h..tapp.....P+..lhhhh...................................................................................................ssh.s.h..hcplc.phG........lp.....................................................................t.ptst.....................t.s..p..t..h..t...s....................p...hsphspp...l..NLDhTsLlshVSsloa.sssph....................................................hppchlp..cQh.....p..E........pp.....p..............lhsp.L.s..hhp....s..+.pL.........................................................................................................................hssppAhpphppIlphlGsssE+pRsp.Lht.p.......s..................................................................ph.pl........p.p....ph..a.shs.thph.hhss....s...t....th....lpts..p..uh.....hh...s................................................................................................................................................	0	49	91	138
+6829	PF07001	BAT2_N		BAT2 N-terminus	Vella Briffa B	anon	Pfam-B_9101 (release 10.0)	Family	This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin [1].	25.00	25.00	25.20	25.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.38	0.71	-3.95	10	243	2009-01-15 18:05:59	2003-08-19 16:36:34	6	1	87	\N	112	219	0	174.00	54	10.12	CHANGED	MS-+uGQssKuKDGK.KYuoLSLFcTY...KGKS.LEsQK..ssVssRHGLQSLGK.VuluRRMPPPANLPSLKAENKGNDPNVslVPKDGTGWASKQ-Qs-scsoss.sspsPEopPsss.ttsss.....pP.ss..sss.ls.uus+SWA.sSsppGupG-Gspt..plssap+cEFPoLQ.AAG-QDKusK-psssDpu	...........................................................................MS-+uGpssKuKDGK.KYuoLsLFspY....KGKS..lE..s..QK..ssVss.R.H.GLQSLGK.....VuhuRR.MPPPANLPSLKAE..NKGND.PNVsl.VPK..D.G.T.GW..AoKQ..-...Qp...-s....c..s...s.....s....s...t..ss...psPEs.P.s..t.ttssss.................ps.sust..s.sspVs..susKS.....WA...ssp...tu...up...s.s...G..h..t...lspa......ppEFPoLp.....AAG-Q-KssKEpts....s......................................................	0	25	38	65
+6830	PF07002	Copine		Copine	Vella Briffa B	anon	Pfam-B_9705 (release 10.0)	Family	This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth [1].	20.70	20.70	20.70	21.40	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.90	0.71	-4.45	18	1157	2012-10-10 16:07:06	2003-08-19 16:56:31	11	19	130	0	676	958	9	139.10	46	27.26	CHANGED	SLHaIusp.psNsYppAlptlGpslpsYDsDchhP...AaGFGu..phs..-hsVoHs...Fslshssps.spCsGlpGllssY+pslPplpLhGPTsFuPIIstsschApt....psuupYaVLLIloDG..lT............shppTh-AIVpAScLPLSIllVGVG	..........................................SLHalsPh...t....NtY......pAlhuVG.pllQcY..Do...D.....Kh......FP.................A.aGF..GA....pl..Ps...c.h.........p.V.SHp..............Fsl..............Nh...s...sp.s.....s...C.p..G.l......pG.l...l.puYppsLs.p....lpL......h........GP.T........s.......Fu.PlIscsAch.A......t................p...s...u......s.....p....Y.al.................LLIlTDGs...lo...........................Dh...p..pT.pcAIVp....AS.p..L.PhSIIIVGVG...............................................................	0	224	337	496
+6832	PF07004	SHIPPO-rpt	DUF1309;	Sperm-tail PG-rich repeat	Vella Briffa B	anon	Pfam-B_8734 (release 10.0)	Repeat	This family represents a short conserved region carrying a PGP motif that is repeated in eukaryotic proteins of sperm-tails. Shippo orthologues from some species may include up to 40 Pro-Gly-Pro repeats.	20.00	3.00	20.00	3.50	19.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.70	0.73	-8.34	0.73	-2.80	323	5278	2009-01-15 18:05:59	2003-08-19 17:13:05	7	51	129	0	3778	5557	23	31.00	24	51.20	CHANGED	sPGPG..s.Y...sspp...................................ttssh...shus+pptt	......................................................sPGPG....s.Y...........sspp....................................................................................t.sth......sht.t....h....................................................................	2	2124	2616	3195
+6833	PF07005	DUF1537	Hop; PF07005; 	Protein of unknown function, DUF1537	Vella Briffa B	anon	Pfam-B_8609 (release 10.0)	Family	This conserved region is found in proteins of unknown function in a range of Proteobacteria as well as the  Gram-positive Oceanobacillus iheyensis.	20.90	20.90	20.90	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.29	0.70	-4.67	131	1723	2009-01-15 18:05:59	2003-08-20 09:55:19	6	19	1153	4	415	1360	256	211.80	26	49.09	CHANGED	Qoptp.....luhlshssl....tG..st..slpsplsphtspuh.phslsDAhsspDLttlupAstphs..........LhsGuuG..luhuLst.....thtttshhst.tst.s.......................................ss...sllluGSsSssTppQlsth...psshss....lplDsttlh.....t.......ts.h.....ppshshstsphsps...ss.llassssspsspsspt.phthtttu.h............lppsLuplstpl.h...........pt.u..lppllluGG-TSusVsps.Lulsulclss	.......................................................Qst..ss.lshpsl......tpG..st....slpttLspl....p.....pp..Gh..phsVlDAls-pcLphhu.pAltp.ts..............LlsGuuG..luhuL.up.....p.hsptstttt...t..............................................sstsllluG...SsSphTppQlsth....c..p..t..s..ss...........hplD..stphl.......................p...htshh.......ppl..hphshsthspt....ts...llhso..t..s..s..p....s.htslpp.....th.t.....t.....p..thupt...........................lpphhuplstpl.h...........tp.s......lst.h.llsGG-TSu.sVsps.LGlpuhclt.......................................	1	108	236	339
+6834	PF07006	DUF1310		Protein of unknown function (DUF1310)	Moxon SJ	anon	Pfam-B_10153 (release 10.0)	Family	This family consists of several hypothetical proteins of around 125 residues in length. Members of this family seem to be specific to Listeria and Streptococcus species. The function of this family is unknown.	30.10	30.10	30.20	30.30	29.50	30.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.40	0.71	-4.60	18	373	2009-01-15 18:05:59	2003-08-20 10:41:32	6	2	106	0	22	303	0	116.40	36	85.44	CHANGED	K..+WllllhhhLlslhhlGuthYhcccpc....pc..EMhpllpS-EAKcVaEctLKslDscAhTccGlI+oYcIDcpSIcpNPMGGI.VcLlINcDscLhlpasLp+ss.pGcLcuuuhshSscLscLL	.....................hlhhhhlslhsh.h.hl.G.st.hhhs.p...cp........pp...EMhpllpScEsK.plhEctL+plDscAhTc...c...GhIpSYcIDcpSlcpNPMG.G.I.lpllIN.sD.clhlphslp+.....ps.....Gc.lpssu..hs..hStcLscLL..................................	0	5	6	17
+6835	PF07007	DUF1311		Protein of unknown function (DUF1311)	Moxon SJ	anon	Pfam-B_10506 (release 10.0)	Family	This family consists of several bacterial proteins of around 120 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.54	0.72	-3.89	182	2203	2009-09-11 12:01:10	2003-08-20 10:44:19	7	31	1231	2	507	1711	82	90.10	22	47.59	CHANGED	sC....psst..sssphth.Cs..stp..hpthDpcLspsY...pphhpphs.............tttt........ptLc...p....uQ+sWlph.R-tpCthttt..........t...........tsCh..hphsppRhtpL	..........................................................C....ttst..st.hphhh..Ct...s.tp..hpthDtcLspsY...pphhpphp............t.tp....................stLp.p......uQ..psWlph..R-t.pCt.h...t.............................hsChhphsppRhttL............................................	0	105	233	375
+6837	PF07009	DUF1312		Protein of unknown function (DUF1312)	Moxon SJ	anon	Pfam-B_10829 (release 10.0)	Family	This family consists of several bacterial proteins of around 120 residues in length. The function of this family is unknown.	29.60	29.60	31.60	30.10	29.30	28.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.37	0.71	-4.26	40	812	2009-01-15 18:05:59	2003-08-20 10:52:32	6	4	615	16	142	554	21	112.80	29	80.84	CHANGED	ll.llllllluhhslhhh.............t.psspsthAlIpl-G+lhpplsLsc.ptspphpl....psspthNllclcsspl+hp-us...CPDplCV+pGhIs+sGps.IlCLPp+llIcIp...uspp.pp	............................................................................lIhhlllhu.hhslhhh......................tttppsssthAl.l.pl.....-G..c..hc.phsLsp..t..ppphpl...................sspsthN.hl-.l.cssclRlp-us...CPDplCV+pGaIs+.sG.......po..IlCLPc+lllclcuspt..s..............	0	74	124	133
+6838	PF07010	Endomucin		Endomucin	Moxon SJ	anon	Pfam-B_10834 (release 10.0)	Family	This family consists of several mammalian endomucin proteins. Endomucin is an early endothelial-specific antigen that is also expressed on putative hematopoietic progenitor cells. 	20.90	20.90	20.90	23.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.73	0.70	-5.05	3	39	2009-01-15 18:05:59	2003-08-20 11:05:11	7	2	26	0	17	52	0	160.40	53	87.87	CHANGED	MRLLQVTlLFFLLSNSLC+SEsuK-stNsSLs...ETSTTKASlTTPshVSl.pNsNKPTsGTPPKGTTsS-lsKTSLMoTlsSLTTPKHEltTTTcGVlKNESSThKlTVsNsTlSNAVSTLsSSQNKTENQSSIRTTEI.ssTslL.sDApPKpTuT.oSASLTTA+ThSQlQ..DTEDGKIAoToSTTPSYSSIILPVVIALIVITLLVFTLVGLYRICWKRDPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN	.........................................................................................................................................................................................................s.....................................s.s...........t.tp.sss.t.s......ShSu.II.LPVVIALIVITLSVFlLVGLYRhCWKsDPG.s.EsGs.-QPQSDKESVKLLTVKTISHEoG.......................	0	1	1	4
+6839	PF07011	DUF1313		Protein of unknown function (DUF1313)	Moxon SJ	anon	Pfam-B_10989 (release 10.0)	Family	This family consists of several hypothetical plant proteins of around 100 residues in length. The function of this family is unknown.	20.40	20.40	20.50	60.40	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.98	0.72	-4.32	12	107	2009-01-15 18:05:59	2003-08-20 11:07:00	6	2	42	0	55	103	1	87.10	52	69.78	CHANGED	stutDuclhpshppSFsQVQulLDQNRhLIpclNpNHpSRhsDsLsRNVuLIRELNsNIp+VlslYuDLSssFupsh..ctupp....ussosss	...........s.tsDsKlhpsFp+SFsQVQslLDQNRlLIsEINQNHES+hPDNLoRNVuLIRELNsNIpRVVsLYuDLSsoFs.+oh.csssp....upss..s................	0	9	37	47
+6840	PF07012	Curlin_rpt		Curlin associated repeat	Moxon SJ	anon	Pfam-B_10299 (release 10.0)	Repeat	This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilisation of CsgA and CsgB [1]. 	20.70	20.70	21.10	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.46	0.72	-4.23	22	2923	2009-01-15 18:05:59	2003-08-20 11:21:28	7	10	529	0	240	818	103	32.30	40	50.36	CHANGED	GssNssslp.QtGssN......tuhlsQh.GssNpsplsQtG	..............sssp.hplp.Q.t.GssN............sAh.ls..Qp..Gs.ss.cssloQhG..........	0	40	67	153
+6841	PF07013	DUF1314		Protein of unknown function (DUF1314)	Moxon SJ	anon	Pfam-B_10999 (release 10.0)	Family	This family consists of several Alphaherpesvirus proteins of around 200 residues in length. The function of this family is unknown.	25.00	25.00	90.20	89.90	22.40	16.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.14	0.71	-4.88	5	24	2009-01-15 18:05:59	2003-08-20 11:24:38	6	1	18	0	0	20	0	170.40	41	75.45	CHANGED	c+sLLcuLuGRslDLPGGG-.LtIssssGps...hs+FspuGouRsshl+aIGRAhTsGssRcFlIatu+-..GsVYGYEsuTGLHhLAcSLHDFLsp+GLSQRDLhVlcGshhcuclssLsh..phh+soS-ssplssp.oschstsTsssuctspSoo+Rs...oLuslss....shpsp+lls+GS	scsLLcsLuGRslDLPGGs-.ltIssssGps...ht+appsGsp+hshs+hIGRAhs.GssRcFllhhs+s..uslaGYEsuTGLHhLApSLH-FLpppGLSpRDLhlhcushhshphpslsh....hpsoops.plshp.sss..hsTtsssptppooocRs...sLsslss.....hpspphls+GS.............................	0	0	0	0
+6842	PF07014	Hs1pro-1_C	Hs1pro-1; 	Hs1pro-1 protein C-terminus	Moxon SJ, Vella Briffa B	anon	Pfam-B_11205 (release 10.0)	Family	This family represents the C-terminus (approximately 270 residues) of a number of plant Hs1pro-1 proteins, which are believed to confer nematode resistance [1].	25.00	25.00	68.20	63.10	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.88	0.70	-5.06	5	41	2009-09-11 08:44:19	2003-08-20 12:04:16	7	3	20	0	24	44	8	248.10	56	59.96	CHANGED	MpRCsYTLGLGEPNLAGKPsLcYDAVCRPsELHALK.......csPYsD+I-NpENQsLaTIHQILESWIauSspLLsRIssRIEcc+FEKAAsDCYlLERIWKLLAEIEDLHLLMDP-DFL+LKcQLpIKSou.cs-AFCFRSKGLVEVsKMSKDLR+KVPsVLuVEVDPsGGPRlQEAAMKLY..cRKoEaE...KIHLLQAMQAVEuAsKRFFFGY+QLVAAMMGSAEANANRslh..SsESsDSLoQlFLEPTYFPSLDAAKTFLG-FWs+c	......MptCsaTLGLGEPNLAGKPsLcYDtVC+PpElHuLK.......posa..hh..c.NpENcsLaThHQIlESWlpsuppLLpRlscpIcs+saEtAApDCallERlWKLLs-lEDLHLlMDPDDFLRLKpQL........ul....+......oss..p...s........u.....uFCFRS+tLlcls+hs+DL+++VPplLuVEVDPpGGPRlQEAAM+LY........pc+sthE...............KlaLLQAhQAlEsAh+pFFauY+QllssVMGouEupustshh..ss-uhDsLoQhFLEPsYFPSLDAAKTFLupaWsp.p...............	0	8	17	20
+6843	PF07015	VirC1		VirC1 protein	Moxon SJ	anon	Pfam-B_11309 (release 10.0)	Family	This family consists of several bacterial VirC1 proteins. In Agrobacterium tumefaciens, a cis-active 24-base-pair sequence adjacent to the right border of the T-DNA, called overdrive, stimulates tumour formation by increasing the level of T-DNA processing. It is thought that the virC operon which enhances T-DNA processing probably does so because the VirC1 protein interacts with overdrive. It has now been shown that the virC1 gene product binds to overdrive but not to the right border of T-DNA [1]. 	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.35	0.70	-5.28	4	74	2012-10-05 12:31:09	2003-08-20 12:08:44	6	2	60	0	21	1997	816	212.80	28	93.83	CHANGED	MpLlThCSFKGGAGKTTALMGLCuuLAucG+RVALFEADENRPLo+W+ENAhppusWDstCElasADELPLLEsAYEpAEspGFDYALADT+GGuSELNNTIIASSsLLLIPTMLTPLDlDEALuTYRYllELL.luEsLsIPsAILRQRVPssRLToSQphh.-MLEpLPlhDsPMaERDAFAAMK-RGMLHlsltNhupsPoMRLhhRNlctAh--lshluchlpcsLEu	........................M.llshsS.KGGuGKTT..u.h..hhLu..s.tl....A.....p.....p..G.....p....p..Vs.....llDAD....s..N.........p....s...l.s.p....W.....t..p..t....s.......t..t...s.......s...h......s......s........h...p......l....h..s..s..s...c......s...h..l...c..th....h...p....p...s...p..t..p.s.h...s.al.l.lDh...c.G....s..u...o...t..h..s.s...h...s..Iu.p..u.D.lllI...Psthoth..Dh...c....pAhp.sh.phlt..c.......h...psh..p..h...p....I...P..h....s.V..l.h...o..+..s...s....s....t....t..h.pp...t.p..c.h.h.p.-h.....h......p...p......l.....P.......l...h...p...s.......hh-.R....sAa..pu..h.hp.h.G..h.............................................................tt...................................................................................................................................................	0	7	17	19
+6844	PF07016	CRAM_rpt		Cysteine-rich acidic integral membrane protein precursor	Moxon SJ	anon	Pfam-B_11042 (release 10.0)	Repeat	This family consists of several 24 residue repeats from the Trypanosoma brucei cysteine-rich, acidic integral membrane protein precursor (CRAM). CRAM is concentrated in the flagellar pocket, an invagination of the cell surface of the trypanosome where endocytosis has been documented [1].	19.10	19.10	27.40	19.60	16.00	15.40	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-7.89	0.72	-4.60	2	132	2009-01-15 18:05:59	2003-08-20 12:15:35	6	4	4	0	60	150	0	23.90	95	108.27	CHANGED	.sDDCNITGDCNETDDCsITGDCN	.ETDDCNITGDCNETDDCNITGDCN....	0	2	60	60
+6845	PF07017	PagP		Antimicrobial peptide resistance and lipid A acylation protein PagP	Moxon SJ	anon	Pfam-B_11014 (release 10.0)	Family	This family consists of several bacterial antimicrobial peptide resistance and lipid A acylation (PagP) proteins. The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response. 	21.90	21.90	22.90	24.40	21.40	18.60	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.96	0.71	-4.89	10	610	2009-09-10 16:46:51	2003-08-20 13:10:46	6	3	581	4	62	268	7	143.80	76	77.22	CHANGED	pNVupTWsps.spDLYlPslTWHNRasYDcEKIDsYNE+PWGuGYGhSRYDEcGsWHGLYhMAFpDSHN+aEPIsGYGapKhWpPsp..pDa+hGlGaTAulTARc-a.sYIPIPslLPLASluY+plohQuTYIPG....TYNNGNVLFuWhR	..........................NlApTWpQPEHYDLYlPAITWHARFAYDKEKT..DRYNERPWGuGFGhSRWDEKGNWHGLY..AMAFKDSaNKWEPIuGYGWEpTWRPL.s.D.-NF+LGLGFTAGV..TAR....DN.W.NYIPlPVLLPLASlGYGPsTFQMT...YIPG....TYN.NGNVYFAWMR................................	0	4	23	43
+6847	PF07019	Rab5ip		Rab5-interacting protein (Rab5ip)	Moxon SJ	anon	Pfam-B_11031 (release 10.0)	Family	This family consists of several Rab5-interacting protein (RIP5 or Rab5ip ) sequences. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5 [1].	21.40	21.40	21.60	21.50	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.67	0.72	-3.85	38	446	2009-01-15 18:05:59	2003-08-20 13:25:37	7	12	273	0	301	409	2	82.00	27	60.80	CHANGED	pslhasRphh.........ullhGlsuGlLsLpGhh.Ghlhahlsshhhshhhhs..phtpss.........cpaatshpclh.hpGlhsulss..........Fl....lsWshh..........Y	............sl.ahRphh.........ullhGlsuGlLsLpGhh.GFlha..hlhshhlsh.lhhs...pht.p.s.................................cpha.t.u.hhplh.ppG..hhs..uhhs........................Fl....lhWhhhY...............................................	0	96	159	244
+6848	PF07020	Orthopox_C10L		Orthopoxvirus C10L protein	Moxon SJ	anon	Pfam-B_12732 (release 10.0)	Family	This family consists of several Orthopoxvirus C10L proteins. C10L viral protein can play an important role in vaccinia virus evasion of the host immune system. It may consist in the blockade of IL-1 receptors by the C10L protein, a homologue of the IL-1 Ra [1]. 	25.00	25.00	34.80	32.80	22.10	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.31	0.72	-3.45	4	34	2009-01-15 18:05:59	2003-08-20 13:30:38	6	1	19	\N	0	28	0	62.90	80	98.48	CHANGED	MSucGt....SpGGhapsFhps.sGusKts+ohoSGGG........uMWGG......................GuSuGlpuGVpGGVNGGVNuGsuKI	...MSSKGG.....SGGMWSVFIHGHDGSNKGSKTYTSGGG...........GMWGG.......................SSS..GVKSGVpGGVNGGVKSGTGKI....	0	0	0	0
+6849	PF07021	MetW		Methionine biosynthesis protein MetW	Moxon SJ	anon	Pfam-B_11086 (release 10.0)	Family	This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalysed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganisms the reaction is catalysed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells [1]. 	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.11	0.71	-4.93	6	667	2012-10-10 17:06:42	2003-08-20 13:50:55	7	7	656	0	204	5525	4101	186.90	43	86.71	CHANGED	RsDachItchI.PGSRVLDlGCGDGsLLpLLp-pKpVcGpGlElspsGVscClA+GLsVlQGDhDpsLspasD+uFDaVlLSQTLQATRNPcpVL-EhLRIG++sIVSFPNFGHW+sRhpLhs+GRMPVTcsLPYsWYsTPNIHFCTltDFhpLCc-lshpl-cpsAlcttut.h...hspah.NahGchulFhl	.............................................................R.Dh.p..l..Itc.h..l......s...s...S...R...V...L.DL..G.C.G........D.G....p....L....L....p....h.......L.....t........c......p...........+.........p......s........p....G...........h....G.....l.........E....l..........D.........p........s.......s........l..........h.........s......s.........l......u..........+..........G.........l......s........V.............I....p..........t......D........L......-.........c.....G.............L.......s......p.................F..........s......D.....p......S...F...D...h.V.l..L...S....Q.......T...L....Q...A...l....c.....p...P....-.....t......l.....L.....c....E....h....h....R...l.......G....+.....p.....s..I.....V.....o.F.....P..N......F.....G...a........W...+.....s..R.h.....p....l..h..........p......G.+.M...P......V.....o..cp....L......P.Yp.WYs..T............P..N...I.+.......h...s.TlcDFE.tLstch.s..l..cl.l..c...R.hs.l.stpp..............hsphhPNLhuphAlahl....................................................................................................................................	0	67	135	169
+6850	PF07022	Phage_CI_repr		Bacteriophage CI repressor helix-turn-helix domain	Moxon SJ, Bateman A	anon	Pfam-B_11145 (release 10.0)	Domain	This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-9.03	0.72	-3.89	14	693	2012-10-04 14:01:12	2003-08-20 13:57:29	8	9	476	2	136	1419	82	63.90	28	33.13	CHANGED	sslcRlhcAYGFpscppLusaLulu+SThu......................................................................................................shhtR-phP.u-hllpCuLETGsSLpWLssGcGphh	.......................hlcRlhpsh...sh..p..s......p..p..pLuch.LGlupuTlu......................................................................sh.h.t..R...s..s..h..P...s-.h.ll..p.h.u.h...c..s..G.lslpW.LhsGpGt...................................................	0	33	82	113
+6851	PF07023	DUF1315		Protein of unknown function (DUF1315)	Moxon SJ	anon	Pfam-B_11170 (release 10.0)	Family	This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.	25.00	25.00	32.80	32.80	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.27	0.72	-4.10	26	846	2012-10-03 10:59:06	2003-08-20 14:00:57	7	1	840	0	114	362	43	88.00	57	95.55	CHANGED	h-pllpshTPElYppLppAVElGKWPDGpsLTsEQ+-sshQAVMhYps+Hshssccho....GplshKoKpphpt.......................pslthhp	....l.--lIsuMTPEVYQRLsTAVELGKWPDGVALTpEQKENsLQlVMLWQARHNs-AQHMTIsTsGpMVMKSKQpLKccFuhs........................scshshhc.....................	0	17	40	80
+6852	PF07024	ImpE		ImpE protein	Moxon SJ	anon	Pfam-B_11208 (release 10.0)	Family	This family consists of several bacterial proteins including ImpE (Swiss:Q93EC9) from Rhizobium leguminosarum. It has been suggested that the imp locus is involved in the secretion to the environment of proteins, including periplasmic RbsB protein, that cause blocking of infection specifically in pea plants [1]. The exact function of this family is unknown.	25.00	25.00	38.40	77.50	23.60	18.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.53	0.71	-4.16	36	372	2009-09-10 16:41:21	2003-08-20 14:24:06	8	4	347	1	71	256	11	123.30	43	45.34	CHANGED	sussFsWlsDuDsRLGPshEll.ssGpYhWlPaupIpslchpsPusLhDllWpPspls....ltsGststualPsRYsuotps........................ssAh+LGRcTcWp-.hups.shhGhGQ+hahssss-huLh-lpplph	........sssFsWluDSDoRLGPVhEll.suGsYhWlPFupIpSLchspPspLpDLlWpPspls....LhsGssttualPsRYsuScpu..................................sDulRLuRcTsWp.........-....sucs.....sshulGQKsWlT.s...pG-huLhDltphpF......	0	13	30	52
+6854	PF07026	DUF1317		Protein of unknown function (DUF1317)	Moxon SJ	anon	Pfam-B_12646 (release 10.0)	Family	This family consists of several hypothetical bacterial and phage proteins of around 60 residues in length. The function of this family is unknown.	20.60	20.60	20.90	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.92	0.72	-4.09	2	125	2009-09-11 12:57:57	2003-08-20 15:10:15	6	1	114	0	4	77	0	57.50	79	96.27	CHANGED	MKHsHDsIpVGtlhhsYSsh+pGWlhPGhplh+NPhpA.phAEEhNNhhtulpsc...Ls	...........MpHPHDNIRVGuITFVYSVTKRGWVFPGLSVIRNPLKAQRLAEcINNKRsAVCTKHL.LS..................	0	1	2	3
+6855	PF07027	DUF1318		Protein of unknown function (DUF1318)	Moxon SJ	anon	Pfam-B_11321 (release 10.0)	Family	This family consists of several bacterial proteins of around 100 residues in length and is often known as YdbL. The function of this family is unknown.	20.80	20.80	21.00	20.80	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.04	0.72	-3.75	54	739	2009-01-15 18:05:59	2003-08-20 15:21:49	7	2	731	0	142	388	33	94.30	54	81.96	CHANGED	hhuhsu......hAh.sLspA+upGlVGEphsGYLulVt..sss-s.psLVpsINtpR+ApYpclApcN.slol-pVuphAupKhl.p+stsGpalps.sGpWh.+K	.....................................L.hosss.hAL..TL-EARoQGRVGEThsGYL......s.....s......l+.............s......D......AE.....T..ppLVp-INttR+AuYQQLAc.........p......N.sl...o....l..--...lAK...lAGQ.KLV.tRA+PGEYVQGINGKWlRK.........	0	43	80	112
+6856	PF07028	DUF1319		Protein of unknown function (DUF1319)	Vella Briffa B	anon	Pfam-B_10434 (release 10.0)	Family	This family contains a number of viral proteins of unknown function approximately 200 residues long. Family members seem to be restricted to badnaviruses.	28.10	28.10	28.20	59.30	26.30	28.00	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.64	0.71	-3.94	11	50	2009-01-15 18:05:59	2003-08-20 15:23:18	6	1	29	0	0	50	0	127.20	41	80.65	CHANGED	Spps...pL-YLDLAopsKsS..sp-LAHNLplsscRlsLts+V...........................plpplppI.+p.ctpLcclcpclcpLpc-LpsLcp-alpR+PLSKp-Vc-LVlcIoEQPKhIEcQoEtLocELpccV-cl	............t...pL-YLDL.tots...Klo..Np-LuHNLplsh.RhsLss+V...................................plcphppI.cp....lcchp.pclctLppcLpsLpp-alc++PLoKp-VccLVlcIuEQPKhIEcQs.tLoc-Lppclccl.................	0	0	0	0
+6857	PF07029	CryBP1		CryBP1 protein	Moxon SJ	anon	Pfam-B_11415 (release 10.0)	Family	This family consists of several CryBP1 like proteins from Bacillus thuringiensis and Paenibacillus popilliae. Members of this family are thought to be involved in the overall toxicity of the bacteria to their hosts [1,2].	19.50	19.50	20.80	20.30	19.20	18.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-4.49	5	45	2009-01-15 18:05:59	2003-08-20 15:29:38	6	1	21	0	4	42	0	155.90	37	85.48	CHANGED	pElPcplo.ctppKlPFCCVVSIP+GFchVusscPKLVYsLssLSllKETCRKsVpVD-CGpAEVDLHVLKVKGCIPFIuNlEVcPIsscpsCoosPHccpISLSCp-oVCVDHVLKCSVssLPDacIDCcaVsVsDLplpPl+EssCQFVKIoGpFsFaYl	........................thp.ctpp+lPFCCllSlPpGFplhss....s.p.KlVYslssLuhlKETC+KslpV--CGpsElDLpVLKlKGCIsF.lsNh.plc..Phsppphsoo.s....s.........+sppIsLSCpsoVsVDplL..KhSVs..p..LPchpIsspplplpDlplpsh....pEssp...phl+loGtFpFh...........................................................	0	3	4	4
+6858	PF07030	DUF1320		Protein of unknown function (DUF1320)	Moxon SJ	anon	Pfam-B_13638 (release 10.0)	Family	This family consists of both hypothetical bacterial and phage proteins of around 145 residues in length. The function of this family is unknown.	20.70	20.70	21.20	20.80	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.61	0.71	-4.41	48	429	2009-01-15 18:05:59	2003-08-20 15:31:54	7	1	362	0	75	343	19	130.70	24	89.87	CHANGED	YsThsDLhsphuppplhp.................L..sscs.........ssths.shlppAls-AsstIDuaLtuR.Ys...LPL..ssVPslLpphssslAcYhLhspcst.....s-t......lpccYc.pAl+hLcplusGclsLGlss.........ssssssssststhpuspp	................................Yso.pD.lh.tphspp...tlhp..........................L.....ospp...........ssthsps.hlppAls-.Asu.IDuYLtsR....Yp...............l.P.l..............sss.Psl..LpphssslAh.Yp.L.tspps.........s-p........lcccYc.pAlchLcplusGcl..sLulss........ttts..tt.s...h.....tt....................................	0	32	58	67
+6860	PF07032	DUF1322		Protein of unknown function (DUF1322)	Moxon SJ	anon	Pfam-B_13233 (release 10.0)	Family	This family consists of several hypothetical 9.4 kDa Borrelia burgdorferi (Lyme disease spirochete) proteins of around 78 residues in length. The function of this family is unknown.	19.60	19.60	20.00	21.40	19.10	19.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.73	0.72	-3.78	2	124	2009-01-15 18:05:59	2003-08-20 15:53:41	6	2	29	0	8	73	1	72.70	69	85.59	CHANGED	MsK............sEhtppYFphlD.l..cssKYYFPllhsICoYcDVKKh.YcELLEVNRlAslKLpKEhYEhhLuh	..............MpKhN+DIDKAIASLNEoRKKYFNLLDEI..KNDK..YYFPVIMNICSYcsVKKLPYDELLEVNRlA-lKLEKE.LYELILSK...............	3	5	5	5
+6861	PF07033	Orthopox_B11R		Orthopoxvirus B11R protein	Moxon SJ	anon	Pfam-B_13245 (release 10.0)	Family	This family consists of several Orthopoxvirus B11R proteins of around 70 residues in length. The function of this family is unknown.	25.00	25.00	141.50	141.50	20.80	19.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.36	0.72	-4.50	2	31	2009-09-11 15:28:16	2003-08-20 15:58:21	6	1	12	0	0	30	0	71.10	94	81.57	CHANGED	DTsssNVEDIMNEIDREKEEILKNVEhENNKNIpKNHPsEYIREALVINTSSsSDSIDKEVIECISpsVGI	..DTDV.TNVEDIhNEIDREKEEILKNVEIENNKNINKNHPSEYIREALVINTSSNSDSIDKEVIECISHDVGI	0	0	0	0
+6862	PF07034	ORC3_N		Origin recognition complex (ORC) subunit 3 N-terminus	Vella Briffa B	anon	Pfam-B_10452 (release 10.0)	Family	This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication [1].	22.30	22.30	22.30	22.80	20.60	22.20	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.95	0.70	-5.47	13	289	2009-01-15 18:05:59	2003-08-20 16:27:21	6	7	223	0	199	294	2	270.20	24	40.30	CHANGED	K..R............Kputspcsh..hpssspsscchhsphRacsapphWpplcsph-clQcphNt+lh-sLlcFlccstpstptp...h.tp.............pclPTAALls...............GlNhsDH.hpFpsLoppL+sssssaVshLpS+DCsu........lKthlpplltQL......hcsssslctc-p-...........ht.p+sphslssLsoWYp..................pppphsssp.pp................................PlVVIlcDhEsFsspVLQDFIlIhSpalpclPllLVFGlATossulHplLPapVSShLslclFQo.ussppLssVlDclLLosphPF+LSuKVhplLpsIFLYHDFSlpuFI+Gl............KhuhlEHFhspPLSsL	..................................................................................................................t.p..................................p.thphhp.hWtt.pt.ph..p.........pl.pphptphhppl.pFlppt..t...........................................tplPsuhlhh......................GsNh.ssp.hhhppL..tp..tl.p...p.....p........s........s.....h...l...s.L.p.ut-sss.........................................l.+thlppllpph....................................hs.p..s..p.t..p.....................................t..ph...th....s...hp.Lt..saat........................................p..pht..................................................................................................................................................................lVllhcDhE.uFs.splLpDhlhl...h.....S..p..a........h..p........c...........l...........Phh....llhGl..A..T..os..ph..hc...phLsps.sss..h.......Lph....p..h....F...p......sspphlsplhcpllh....s....s.p....h....s..........h...p..l..utplhp.hLhs.hah...pshSlpsFlpul............phshhpHFaspPLShL....................................	0	59	105	159
+6863	PF07035	Mic1		Colon cancer-associated protein Mic1-like	Vella Briffa B	anon	Pfam-B_10041 (release 10.0)	Family	This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.	20.80	20.80	21.20	23.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.69	0.71	-4.89	5	183	2009-01-15 18:05:59	2003-08-20 17:08:55	7	2	131	0	123	177	0	150.30	34	25.00	CHANGED	chhtccsYlluIlMEYLRSLsctpIssptpLacMlIcpLApuscFscLppFVoY+lLp-SKsLAhhLLShuspsosl+QLGlDML+RluhAHDhIlEVLLpcGplL-ALRaA+chtslssVpusKFLEAApposDsQphaAIhRFFoE+p.+h.hh.uFssshcTsE	............................................h..pallullhEYlRSLsp...hp.Is....sp.ch.LacllIptLlppp.t.ahhLcphlpY+VlsDSKslA..phL..LShp..........s..h............a..........ss.s..pQLuLDML+RLs.up-tIlElLLsctplLtALRah+sh.....tt...hss.........l...ss..p+.........FL-AAhpspDs.lhaslh+FFpp..........F.....................................	0	47	65	97
+6865	PF07037	DUF1323		Putative transcription regulator (DUF1323)	Moxon SJ, Bateman A	anon	Pfam-B_12705 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 120 residues in length. This family appears to have an HTH domain and is therefore likely to act as a transcriptional regulator.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.52	0.71	-3.94	10	925	2012-10-04 14:01:12	2003-08-21 10:48:22	6	1	468	0	36	265	4	117.00	62	94.57	CHANGED	MTPEELAchoGYoRQTIN+WVRKcGW+TpPhPGVpGG+ARLlHlsppVREFIpsss..........RlsEssAtY.sssscusl.s.llsslcpMTssEQcQLssLLsREGIsGLLpRLGIR-s	......................MTsEELAchhG..h..uR..QTlN+Wl..Rc.cGWp...Tp.hPGV..pG.G.+.AR...Ll..H.VspQVREaIpNs...........cs.EshAEh..Asuu.cAPh.t.llohscpMTssEQcphsphLsREGI..pGhLpRLGIc-S....................................................................................	0	3	3	21
+6866	PF07038	DUF1324		Protein of unknown function (DUF1324)	Moxon SJ	anon	Pfam-B_12735 (release 10.0)	Family	This family consists of several Circovirus proteins of around 60 residues in length. The function of this family is unknown.	25.00	25.00	140.50	140.30	19.30	18.10	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.11	0.72	-3.94	2	9	2009-01-15 18:05:59	2003-08-21 11:20:11	6	1	6	0	0	7	0	59.00	97	94.82	CHANGED	MpCTLVFQSRFCIFPLTFKSSASPRKFLTNVTGCC.ATVTRlPLSNKVLTAVDRSLRCP	MTCTLVFQSRFCIFPLTFKSSASPRKFLTNVTGCCSATVTRLPLSNKVLTAVDRSLRCP	0	0	0	0
+6867	PF07039	DUF1325		SGF29 tudor-like domain	Moxon SJ, Bateman A	anon	Pfam-B_13304 (release 10.0)	Domain	This domain is found in the yeast protein SAGA-associated factor 29. This domain is related to members of the Tudor domain superfamily such as Pfam:PF05641. The SAGA complex is involved in RNA polymerase II-dependent transcriptional regulation. The membership of the tudor domain superfamily suggests this domain may bind to RNA.	25.30	25.30	25.40	30.20	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.91	0.71	-4.53	20	328	2012-10-02 16:56:36	2003-08-21 11:28:18	6	4	260	14	233	311	5	129.80	33	39.46	CHANGED	phG-pVAAphp.......psstc.........p-WIlucVlphsscs..p+YEVhDsDs-...ppt...taphot+clIPLPp.......s.cssstspFPpGopVLAlYPp.....TTsFY+AhVhss.................sp....ptsspYpLcF-D-p.sst....hpVsp+aVlshsp	....................................h..GspVAh+sp..........ttstc................ppWIlscVlp.hstps...p+......YEVpD.-s-..............ppp.......paphotpplIPl.Pp.......t.pssshs.F.stGppVLAlYPp.......TTsFY+AhVhus.............................................t........pt.p..s...s...YplpF-s-ptsst.....hpVspRaVlsh..p..........................	0	86	129	193
+6868	PF07040	DUF1326		Protein of unknown function (DUF1326)	Moxon SJ	anon	Pfam-B_11597 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins which seem to be found exclusively in Rhizobium and Ralstonia species. Members of this family are typically around 210 residues in length and contain 5 highly conserved cysteine residues at their N-terminus. The function of this family is unknown.	25.00	25.00	29.30	29.30	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.14	0.71	-4.52	34	220	2009-01-15 18:05:59	2003-08-21 11:31:31	6	2	187	0	80	216	231	181.30	31	86.66	CHANGED	htsCsCshhCPC.hs......t.PTp..GtCcuhhuhcI-cGpasslcLsGLsluhlhchPGs.ht-G.....shcssh....alD-cAo-tQhcALhpIhoGps....Gu.hushusllu.chhusthsPIcacscspt......ps..lplsshhphth-shhpPhsGsstcs.hslssssa..........hphucsspsph..pshGh.sachss..ppu	....................h.tsCsCshhCPC.hu......tsPTp..G....pCcuhhua+I-cGpas-lcLsGLsluhls....ph.P....Gs....lt...cG.....shcssh....alD-RAossQtcALhpIaoGps....GGhhuhFuph.lu.chhuschAPIca-scscp......ts....lcls.sh.hp....s.hsPhsGsstcs.hslssssap..h.st...hthucss.psph...cshGh.shshsspp............................................................................................	0	23	49	63
+6869	PF07041	DUF1327		Protein of unknown function (DUF1327)	Moxon SJ	anon	Pfam-B_11630 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 115 residues in length which seem to be specific to Escherichia coli. The function of this family is unknown.	25.00	25.00	25.50	25.30	24.30	23.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.48	0.71	-4.17	3	518	2009-01-15 18:05:59	2003-08-21 11:33:54	6	1	251	0	5	248	0	105.10	69	80.18	CHANGED	MTQDYELVVKGVRNFENKVTVTVALcDKc+FDGEIFDLDISLDRVEGAALEFYEAAARRSlRQVFLDVAAGLCEGDEpLPEKRPlILEAQsVhITY+GKLPGhITGSLKTPPs	.....MppcYELlVKGIpNa.sKlTVTVALc.tth.sh.l.DlsISLDRsEGAsLEFYEAtA++ps+QhFhDVAAGLCEGDt.LPEKRPlILEAQsVhITY+GKLPGhITGSLKhPP..........................	0	1	1	1
+6870	PF07042	TrfA		TrfA protein	Moxon SJ	anon	Pfam-B_12321 (release 10.0)	Family	This family consists of several bacterial TrfA proteins. The trfA operon of broad-host-range IncP plasmids is essential to activate the origin of vegetative replication in diverse species. The trfA operon encodes two ORFs. The first ORF is highly conserved and encodes a putative single-stranded DNA binding protein (Ssb). The second, trfA, contains two translational starts as in the IncP alpha plasmids, generating related polypeptides of 406 (TrfA1) and 282 (TrfA2) amino acids. TrfA2 is very similar to the IncP alpha product, whereas the N-terminal region of TrfA1 shows very little similarity to the equivalent region of IncP alpha TrfA1. This region has been implicated in the ability of IncP alpha plasmids to replicate efficiently in Pseudomonas aeruginosa [1].	20.20	20.20	20.60	20.20	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.93	0.70	-5.59	2	183	2012-10-04 14:01:12	2003-08-21 11:42:26	6	2	103	0	39	169	15	194.10	48	81.52	CHANGED	K++TAGt-LAcpVSEAKQsALLKHTKQQIK-MQLSLFDlAPWssohtAhPNDhuRSAlFTsRNKKlPR.ALQspsIaHVNKDVcITYTGlELRADDDELVatQVLEYAptTslGEPloFTFYELCQDLsWSINGRYYT+AEECLoRLQAoAMtFoSpRlG+LESVSLl+RFRVLDRGK+TSRCQV.IDtEIVVLFAGDHYTKFlWEKYRKLSPs.stRMFDYFuoH+EPYPLKLETFRLMCGSDSTRsKKWREQVGEAC-ELRtsGLVEpAWVNDDLVHCKR	......................................................................................................................s..hhRsslFs..........................................th.l.apG.pL......pt........la.....t.h..h.p...tpt..hs.....t.....h.h...s.hthhptlsht.......st...t.ht.h.tsltR..ht.s.th...t....h.....pt.t..t.t.......................hh.t........................p....t............t............h....h..ht.p.hh.hat.t.ho....h...ht.hR+Lo..P.s.....A..RR.h..F..DY...auoH...+..-.P...Y.PlKLETFRLMCGS-S.s..R.sKKWREQ.l.ucAC-EL+csG.L.V-s.AW....l.s..s...........................................................................................................................................	1	7	19	31
+6871	PF07043	DUF1328		Protein of unknown function (DUF1328)	Moxon SJ	anon	Pfam-B_12535 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 50 residues in length. The function of this family is unknown.	21.00	21.00	21.70	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.05	0.72	-3.97	105	1343	2009-01-15 18:05:59	2003-08-21 11:48:34	8	1	1124	0	357	687	48	39.40	58	70.82	CHANGED	llFhlIAllAulhGFuGlAuuAAuIAKILFalFLllhll	.....lIFLVIALIAAsLGFGGl.A.GsAAGhAKIlFhVhllLFlV..................	0	81	194	276
+6872	PF07044	DUF1329		Protein of unknown function (DUF1329)	Moxon SJ	anon	Pfam-B_12608 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica.	23.10	23.10	23.20	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.11	0.70	-5.52	104	761	2009-01-15 18:05:59	2003-08-21 11:53:27	6	4	350	2	275	746	454	269.20	22	78.32	CHANGED	sIoApN...hspYp..........cpLosGQhAhlKpYPs.a+hsVYsT+RosshPptlhcss+pNAspscLsss..Gsu.lp...shh.su..lPFP.l.....P..psGhEllWNahhRa+...Gt.shppthsphsspssGshs..hsphppphhhhhhh.stsstp..........sshhhhhh.phpuPu+luGsslLl+-slDp.htp.sRpAWhYssG....QRRVRRAPshAYDsPt.sus-GhtTsDshchFNGusDRY.-WKLlGK+..EhalPYNsYcl.........tsssh+as-llpssHlNP-hhRYELH...RVWVVEATLKsGtRHlYuKRsaYlDEDoWphs.hsDtYDs+GpLWRsspsah........h.hY-ssssh.ssspshaDLpuG.RYhs.shss...cpst.shph......s.ph.pp....spFossAL.Rp	...............................................................................................................................................................................sas.............ttu.......phh.p..h.t.......................h.....sGp...........t....thh......t.t......................tshh.hhh.hhptPscltGsshLshphhsp.....p.pptW.hY.su.....RRVRRhsshs..hcsPhhus.ssh.....hDsh..ph.apst.p.c..a.paphhGpp...hh............................................................php.+...csahlpup.p.....pch...as++hhalDp......Dsa.hh.hh-.YDtp.GpL..a+h..h..........h...p....h.h..h...th.hhhsl.st.+hhh.thtt....tt......h...........h.......t.apstsl.t...............................	0	91	161	228
+6873	PF07045	DUF1330		Protein of unknown function (DUF1330)	Moxon SJ	anon	Pfam-B_12466 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.76	0.72	-4.11	136	1006	2012-10-02 00:20:33	2003-08-21 11:56:04	6	4	649	38	383	984	2554	64.20	30	62.05	CHANGED	sptap.cYtptsssshtpaGGc.hLs+...uGphpslEG..hp.schVllcFPohcsApsaYpSs-YQ.tht	....................................ptat.pYtptsss.s.h.p.p..a..GG.c.....hl..s+....G...u..ph........csl...E...G.......t.sh...s+s..VllEFPohpsAhshYpSs-YQts......	0	92	214	298
+6874	PF07046	CRA_rpt		Cytoplasmic repetitive antigen (CRA) like repeat	Moxon SJ	anon	Pfam-B_12798 (release 10.0)	Repeat	This family consists of several repeats of around 42 residues in length. These repeated sequences are found in multiple copies in Trypanosoma cruzi antigens, Swiss:Q26907 contains 23 copies of this repeat.	21.40	21.40	22.60	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.60	0.72	-3.97	5	164	2009-01-15 18:05:59	2003-08-21 13:07:06	6	8	12	0	5	162	0	41.10	84	82.01	CHANGED	EAEKRKAAEAAKsAEAEKQRAAEATKVAEAEKQKAAEATKVA	.....EAEKQKAAEATKVAEAEKQKAAEATK..VAEAEKQKAAEATKVA.....	0	0	0	5
+6875	PF07047	OPA3		Optic atrophy 3 protein (OPA3)	Moxon SJ	anon	Pfam-B_12863 (release 10.0)	Family	This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity [1]. 	25.70	25.70	26.70	26.70	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.53	0.71	-4.38	19	343	2009-01-15 18:05:59	2003-08-21 13:16:55	7	6	247	0	243	347	2	139.30	29	65.35	CHANGED	PlhKLusLul+plSKPlAshlKppApps.hFRsh.......lhls.AQhhHhh-hphph+hhGh.tpss.......................................pIpPLNE-tAlplGu-LLGEhhIFs.....................VuuuhllhEapRpupp...-s+KEEthppclppLcpchpcLphtl.-phppp	...................................PhhKLssLhl+plSKPl.....A........st.l.....KppA+.........p.......p.h.F.Rph........h.lshAQhhH..........th-h+h+.h.th.hs..h..t.psh...........................................................................................pl.+PLsEppAl-h.........GAcllu.EhhlFs.....................VuuulllhE.hhRpppp....ptp+c..-....php....p....chppL...ppphpplt.t.p.....t.................................................................	0	76	126	198
+6876	PF07048	DUF1331		Protein of unknown function (DUF1331)	Moxon SJ	anon	Pfam-B_12865 (release 10.0)	Family	This family consists of several Circovirus proteins of around 35 residues in length. Members of this family are described as ORF-10 proteins and their function is unknown.	25.00	25.00	93.80	93.80	24.60	17.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.82	0.72	-4.49	3	11	2009-01-15 18:05:59	2003-08-21 13:19:41	6	1	6	0	0	8	0	35.00	96	95.77	CHANGED	MSTAQEGVLTVVALTVYPKVRERRVLKMPFFLLQR	MSTAQEGVLTVVALTVYPKVRERRVLKMPFFLLQR	0	0	0	0
+6879	PF07051	OCIA		Ovarian carcinoma immunoreactive antigen (OCIA)	Moxon SJ	anon	Pfam-B_13720 (release 10.0)	Family	This family consists of several ovarian carcinoma immunoreactive antigen  (OCIA) and related eukaryotic sequences. The function of this family is unknown [1,2].	25.00	25.00	25.70	26.20	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.38	0.72	-4.66	13	172	2009-01-15 18:05:59	2003-08-21 13:37:10	6	3	78	0	83	165	0	101.90	43	49.93	CHANGED	usu..ptsstpts.ptss.........tsuhsYhhop-Et+Vh+ECNcESFahRuLPlusluhllTtulVppGaLpsssRFGulPKVslAsllGYhlGKlSYhpsCtEKhhcL.NS.LG-	......................tt.s...........................huhtah.opEEp+lhpECpcESFWhRulPhussSMLlTQuLlpp.GhLuupP+aGSl.PKlhhAslhGYhsGKlSYhpsCQEKF.cpLc.N.S.LGp............................	0	20	28	45
+6880	PF07052	Hep_59		Hepatocellular carcinoma-associated antigen 59	Vella Briffa B	anon	Pfam-B_10544 (release 10.0)	Family	This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 and similar proteins. Family members are found in a variety of eukaryotes, mainly as hypothetical proteins.	22.70	22.70	23.10	23.10	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.47	0.72	-3.66	46	244	2009-09-14 11:59:59	2003-08-21 14:00:37	6	3	211	0	181	244	2	100.10	35	33.04	CHANGED	cpFs..spTspps.....Dp+M...hpYIEpcLt+........R+t..............ttppssstspstsp.ps..t.............Lhc.hPspLp.............tptt..ttphh..uuIsE...VDLGh-s....Kl+NIEcTEcA++cLh	.......................pFsscTspp-....cDtc...M........hcYIEsELtK...................R+shs..................tppp.pppsp.p.stpc.............tLac.lP-plc....................tppspp.hSsphh.....uGIsE...VDLGl-u......Kl+.NItpTEcAKtcL........................	0	62	94	139
+6882	PF07054	Pericardin_rpt		Pericardin like repeat	Moxon SJ	anon	Pfam-B_13724 (release 10.0)	Repeat	This family consists of several repeated sequences of around 34 residues in length. This repeat is found in multiple copies in the Drosophila pericardin and other extracellular matrix proteins.	21.20	21.20	22.50	21.20	20.00	20.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-7.95	0.72	-4.05	5	240	2009-01-15 18:05:59	2003-08-21 14:29:02	6	13	10	0	103	238	0	33.30	73	44.13	CHANGED	QPGYGSQPGVGuQTGAGQPGYGoQPGIGGQTGAG	.....QPGYG..oQPGl.G.GQ.T..G....u..G..QPGYG..oQPGlGGQoGhG....	1	40	40	83
+6883	PF07055	Eno-Rase_FAD_bd	scADH;	Enoyl reductase FAD binding domain	Vella Briffa B, Coggill P	anon	Pfam-B_10602 (release 10.0)	Family	This family carries the region of the enzyme trans-2-enoyl-CoA reductase, at the very C-terminus, that binds to FAD. The activity was characterised in Euglena where an unusual fatty acid synthesis path-way in mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The conserved region is seen as the motif FGFxxxxxDY [1].	25.00	25.00	27.10	33.60	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.93	0.72	-4.03	65	659	2012-10-10 17:06:42	2003-08-21 15:13:17	7	3	532	5	160	538	83	64.90	50	16.50	CHANGED	tlD-csRlRhDDhELcs-VQspVppLWsplTs-Nl.h-loDapGYKpEFLpLFGFsl-GVDY-ADV	......lDscsRlRhDDaELcsDlQpplpcLWsQlTs-Nl..ppLoDasGYKpEFlpLFGFsl-GVDY-ADV.............	0	41	82	120
+6884	PF07056	DUF1335		Protein of unknown function (DUF1335)	Vella Briffa B	anon	Pfam-B_10636 (release 10.0)	Family	This family represents a conserved region approximately 130 residues long within a number of proteins of unknown function that seem to be specific to the white spot syndrome virus (WSSV).	25.00	25.00	142.30	141.60	19.40	18.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.64	0.71	-4.41	5	17	2009-01-15 18:05:59	2003-08-21 15:24:03	6	2	2	0	0	12	0	128.90	46	28.59	CHANGED	DKsFpFSPLYRhIoc+LSsAsh+cc-phIVoTDFLlGLGFSscNVo+pLKuMEpsh.ppGhppohVPVsDICHRppYKGchIsNPIsuSaSspCLIVPLshLGtlFSpssaPSutsl-sYhusLssAVllY	.DKsFpFSPLYRhlpcpLSpAsh+cp-hhIloTDFLlGhGaospsVs+pL+sMEphh.ppshtpohVsVh-ICHRhpYKGthIsNPIhtSaSspCLIVPlshLGhlFupssaPSutslcsYhusLh.AlllY	0	0	0	0
+6885	PF07057	TraI		DNA helicase TraI	Vella Briffa B	anon	Pfam-B_10638 (release 10.0)	Family	This family represents a conserved region approximately 130 residues long within the bacterial DNA helicase TraI (EC:3.6.1.-). TraI is a bifunctional protein that catalyses the unwinding of duplex DNA as well as acts as a sequence-specific DNA trans-esterase, providing the site- and strand-specific nick required to initiate DNA transfer [1].	20.60	20.60	20.60	22.90	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.45	0.71	-4.13	8	282	2009-01-15 18:05:59	2003-08-21 15:48:57	6	11	224	2	13	255	4	121.40	78	9.48	CHANGED	VuLSRhKpHVQVYTDN+psWssAlsp..usptuTAHDlLEP+sDRpVtsAsRLhuTAppLccTAhGRAVL+puGLtpspohA+FIuPG+KYPpPaVALPsaD+NGKpAGlhLssLsscDss.hRsltGE	...VALSRMKQHVQVYTDNRQGWTD.AINN..AVQKGTAHDVhEPKsDREVMNA-RLFSTARELRDVAAGRAVLRQAGLAGGDSPARFIAPGRKYPQPYVALPAFDRNGKSAGIWLNPLTTDDGNGLRGFSGE............	0	1	1	9
+6886	PF07058	Myosin_HC-like		Myosin II heavy chain-like	Vella Briffa B	anon	Pfam-B_10658 (release 10.0)	Family	This family represents a conserved region within a number of myosin II heavy chain-like proteins that seem to be specific to Arabidopsis thaliana.	19.60	19.60	37.30	20.70	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.01	0.70	-5.36	3	95	2009-01-15 18:05:59	2003-08-21 15:55:57	6	5	21	0	62	100	1	292.60	55	56.63	CHANGED	MVDDLQNKNQELMKQIEICQEENKILDKMHRQKVAEVEKLoQSVRELEEAVLAGGAAANAVRDYQRKFQEMNEERKTLERELARAKVoANRVATVVANEWKDuNDKVMPVKQWLEERRFLQGEMQQLRDKLAIoDRAAKSEAQLKEKFpLRLKVLEEoLKGPoSSuoRsTo.uRSpSNGPoRRQSLGGAEs..KFTSNGuLSKKsPSSQLRtSLTusuooVLKHAKGTS+SFDGGTRSlDRSKlLlNGP.uNasLNcKuoEsopcuE.....p.sSE+KsEpEDscAsoEDSVPGVLYDLLQKEVIoLRKAucEKDQSL+DKDEAIEMLAKKVETLTKAMEVEAKKMRREVAAMEKE	...........................hVDDlQN+NQELhKQIEICQEENKILDKhHRQKVuEVEKLoQTV+ELEEAVLAGGAAANAVRDYQRphpEhNEE++TL-RELARAKVoANRVAs.VVAN..EWKDsNDK.......VM....PVKQWLEE...RRh..............LQGEMQpLRDKLAluERsA+uEAQLK...........-KhpLRLKVLE-uL+ssss.s.s.sps.....s......s+o.....s.........su...s.RR....pS.......lGus...-shsph.s.N..Ghh.++ps..s.p.RsSl.s....sss.....l.l..+.puc.........t..s..S.....+ShDG...u..s+ul-.......p.t....K.hh..hsG..............h.....h.p.........p.tsctspttp................................p.ssp.p.t.....p.....phss....s.....pspD.VsGhLYDhLQKEVlsLRKusc-KDpoL+DKD-AIEMLuKKV-TLTKAMEVEuKKhRRElAuhEKE..............................................................................	0	14	40	51
+6887	PF07059	DUF1336		Protein of unknown function (DUF1336)	Vella Briffa B	anon	Pfam-B_10173 (release 10.0)	Family	This family represents the C-terminus (approximately 250 residues) of a number of hypothetical plant proteins of unknown function.	20.70	20.70	22.70	21.00	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.49	0.70	-4.94	20	403	2009-09-14 23:05:42	2003-08-21 16:08:14	7	20	43	0	274	397	12	194.50	33	37.25	CHANGED	Wo.ssssssFplRGcoYhp.DKpKhPAssh.hhp.lGlDhFpusc.+............hccIupphst.stpstpp...tls.......alhllNlQlPs..............u-shSlVlY.....Fthpcshpc.........tsLlcRFlctD.....DuF+.......ppRlKllssllp.G....sWhl+psV..hspKPsLlGptsppsah....cGsN......YhEIDlDlus.ShlA+sllchhhuhlsslllDluhhIQupstEELPEplLsslRLNcl-	....................................Ws..sssssFhlR.GpsYhp.....c...........+p..............Khs.usp..hhp.lusDhhpssp...+..................................hcclstp.........t........s...thhtp................th.........hhhllNlQ.l.Ps...............................spthShVhY.............ahhpp.h.t.........................pllp+Flp..sD........csF+..............................spRhKllst..lsp.u............................shhl+.phV....sppssLl.s.p..thp.pp.ah............pGss........................Yh.ElDlDlts..ShlAptsl.phhhs.hlpslslDhuhllpu...ppt-ELPEp..lLGssRlspl-........................	1	101	204	245
+6889	PF07061	Swi5	DUF1337; 	Swi5	Wood V, Studholme DJ	anon	Wood V	Family	Swi5 is involved in meiotic DNA repair synthesis and meiotic joint molecule formation [1][2][3].  It is known to interact with Swi2, Rhp51 and Swi6 [1].	20.60	20.60	20.90	32.70	20.50	18.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.87	0.72	-4.20	20	177	2009-01-15 18:05:59	2003-08-21 16:39:21	6	8	155	0	119	162	1	83.60	31	40.18	CHANGED	phpshpsphssLcp.pht.....phcpplu-hpup............psPpppVc+HI+LLHEYN-lKDlGQtLlGhIADtRGl+tt-lacEaGlshs-	................................................................p.......phtplcp.p.t............thpp..plpph.tsc..............................t..tstptlccHIphLHEYN-lKDlGQtLlGhlA.sh+GVphp-lap-..aslshp....................	0	39	62	92
+6890	PF07062	Clc-like		Clc-like	Vella Briffa B	anon	Pfam-B_11218 (release 10.0)	Family	This family contains a number of Clc-like proteins that are approximately 250 residues long.	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.46	0.70	-5.08	5	78	2012-10-03 00:20:40	2003-08-21 16:52:45	7	3	13	0	70	76	0	179.30	26	62.97	CHANGED	plllhsSLlLolVuhsLouAAlhTPSWQVVDlREaRuhHQHGLWLDCsRtpp...Hllp..s.hs-sPLHCsYKFDhDuh.sYppsl-shD....psussGEsc+HpFaGWH+ulLhlhlhShlhAuLSlhSGlCAsCssupA....lhaoIhlslAuLluslu-uIFFlsAaRVDsRFl.pGlVGTYEQ+lGYAFYLplsGshlallAllhAsLsoYhoFlsuc	.........................................t....hhshlhhlluhhL.hhuhhoPuWQ.l....sphp-hpt..hppGLWhsChp..p...................................t..........hpChY+Fs....ss...ht....t..c..............tssttsc.p.pcpF........a.....s.W+huslhhhhhuhh..huhlul...hh...uhCu.sh.shu....lhhslhh.hhsslhuhhu.hlFhhhuph....h.......-s+al....uhsspYE......pc..hGhuaYlthhush.h.hhuhlhuhhhsh......p...................	0	26	34	69
+6891	PF07063	DUF1338		Domain of unknown function (DUF1338)	Vella Briffa B, Bateman A	anon	Pfam-B_10864 (release 10.0)	Domain	This domain is found in a variety of bacterial and fungal hypothetical proteins of unknown function. The structure of this domain has been solved by structural genomics. The structure implies a zinc-binding function, so it is a putative metal hydrolase (information derived from TOPSAN for PDB:3iuz).	20.90	20.90	22.30	21.60	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.84	0.70	-5.36	94	1224	2009-11-20 14:21:51	2003-08-21 16:56:52	8	5	1137	6	261	849	170	336.20	41	87.14	CHANGED	tpphhpuL.phYhp.csPpstslh.cLlsp....sspplhp..........................DHhAlRoh........sssshslssls+hFtshGatssGh........Ych.sstp...lpuptFc.s...............csst........s+lFlScLcl-plo...sphpphlppll..........hsttshphl............pth.........................thlsthLts..................hpW..pt...sshssYppLtpESchsAWlss.pGhphNHhTspl.............................-Icplppthpp.....pGhshp....ut............................................................................................lcGsPp.....hhLcQoShhA.p.slpF............t-s.....sptphsusFhEhtpR....................................................................................................st........t....p.hha-sFlssSAstIFcSTh	................................................................ppFupAhSsMYppE.VPpYuTLl.-LVuc.......lNhsllptp.thtt..................sthtRls.ERHGAIR..........lGostELusLpRhFAhhGMhPVuY........YDL.spAus...PV+STAFRPl...............DsssLth.....sPFRV.FT.ShL+lEh...lp..pttLRppstclL.....tpRplFospshpLl............cph-tp.............GG.hsttpAppFltps.Lcs..................F+W..cpps.VsppsYcsLppEpclhADVlsh.GsH.INHLTPRs............................LDIDpVpshMsc.....pGlp.K.....sh............................................................................................IEGPPcpp.sslLLRQTSF+ALcEsVhF.............ssp.......hpGshsuRFGElEpRGhALT.cGRthY-thht...........................................................................h.........t......tshsps........hhttGhh.tpPlsYEDFLPsSAAGIFpSNL..........................................................................	0	52	116	189
+6892	PF07064	RIC1	DUF1339; 	RIC1	Vella Briffa B, Wood V	anon	Pfam-B_11581 (release 10.0)	Family	RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network.  It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor [1].	20.90	20.90	24.10	22.50	18.40	16.50	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.61	0.70	-4.94	21	304	2009-01-15 18:05:59	2003-08-21 17:06:16	8	12	258	0	221	323	0	244.90	30	21.67	CHANGED	sLc-uLWhasG.pthp.........sWhsh.s.......t......tp.....lsc.l.ls..l-hYPLulLhsculllGsps-hh............pppsssashhchphcoplaL..lLpthL...........hps...........hstpAhplspphppLsYFsHsLElLLHpVL--Esss..............s.psslLPsVluFLpp...aPpaL-lVVpCsRKTElppWphLFshlGsPp-LFccCLppppLcTAuuYLllL...................pshE.stus......spppsl+LlphAlcppcW-Lst-LsRFLtulDsststh.p	...............................................................................................................l.psLWh.tG.tthh................lWh.sh.............................t.t..p................h..t.l.ls....hphYPLulLhppu..l..llGspschh................................php...hth.....shhphphp.o....plaLpplLcphL....................tps...........hs.pAltlu...pp...h.....p.p..LsaF.sHsLElLL.H.p.VL--.Esssp..................................................................sh.cslL...splhphlpp................F.s...a............LclVVpCsRKTE....hthWp.h.LFs.hl.u.s.Pp...-LFE.......cCLp.tppLc.TAuuYLllL............................................pshE...ssss..............sp...ppus.pLlpt....A........hp.......p........sc........W-Lst-LhRFLtulspstp....p....................................	1	73	119	183
+6893	PF07065	D123		D123	Vella Briffa B	anon	Pfam-B_10915 (release 10.0)	Family	This family contains a number of eukaryotic D123 proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate [1]. D123 proteins are regulators of eIF2, the central regulator of  translational initiation [2].	19.30	19.30	19.30	19.30	18.70	18.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-12.13	0.70	-5.34	23	384	2009-01-15 18:05:59	2003-08-26 10:47:36	9	6	285	0	263	392	8	253.20	27	73.76	CHANGED	WYsh...F+ph.Th+ohlI.PLPc..shlcYLtpDG..lhlspppss...........psssssphs-..pt.sDspstp..........ssscFPEhp..pplp-AIppLGGtVhPKLNWSAP+DApWIsssso...lpCpsssDlaLLLKuS-alsHDLsc..satt.s.D............cpsttt........saELVLRcWh.clpPuhEFRCFV......KspcLluloQRDh.sYY-aL..tc....c-plpstIppFa....c-pl...h.pF....sscsaVhDVYlsp.....s+lhlIDhNPauc.pTDsLLFoWsELpshtt..........ptpsp.-hRll..........sstsphts.ppasp.plPhDhl-sops	....................................................................................................................................................W......att..s.pshhl..ls......thhpYL.tDs..hhls...t.........................................pttt.p..p....t...tppttt.................................pas-h......p..tplppsI.pp...hG...Gt.......V....hPKLNWSuP+DAhWh....s.so.......................hpCpshs-laLLL+uSs.hls+DL..pp...satt.s.s...................................................t....h..............th.LlLRcah..sl..p..PuhEFRCFV................+pppLl.uloQR-h...p...aa....s.al....t...........ppplhptIpp...Fa.................pppl...........t..pa.......psalhDl.Yhsp......................t+lhllDhNPau...h....T..csLLFsWpE.l.t.t........................................................h.ph...........................................s.............................................................................	1	101	163	227
+6894	PF07066	DUF3882	Phage_Lacto_M3;	Lactococcus phage M3 protein	Moxon SJ	anon	Pfam-B_13997 (release 10.0)	Family	This family consists of several Lactococcus phage middle-3 (M3) proteins of around 160 residues in length. The function of this family is unknown.	22.10	22.10	22.20	22.30	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.10	0.71	-4.38	2	63	2012-10-03 01:22:09	2003-08-26 11:41:59	6	1	61	0	2	51	62	148.30	62	96.44	CHANGED	MpKhLAIDFSTus.....TGYAFRp..ssphhVGSI.Ahs.pKsshERsh.IssuIp-lI-casLhsYalhIEpPIhshppKtsIoLhpsNG.FlGshcshhN.GYs.lsNSKWCuYHLIpGKpt.RK.pSlElLKuhslVssNshsDshADAasILhYsEp	.............................MSKALAIDFSTSN.....TGYAFRNP.LTNE..YVV.GSI.A.GGKSKDPL.E.RAKlIADGITEl....IEHYNLFD...YF.....IYIE.E.PIITFKSKGNISLIRANGSF.LGV..M.RNR...HN.IGYVDls.NSKWCGYHL...IKG.KSthRKs...QS.IE.IL.KS.a.sIVP..cc.....cIN.DD.ADAFCILLYVES..................................................................	0	1	2	2
+6895	PF07067	DUF1340		Protein of unknown function (DUF1340)	Moxon SJ	anon	Pfam-B_14083 (release 10.0)	Family	This family consists of several hypothetical Streptococcus thermophilus bacteriophage proteins of around 235 residues in length. The function of this family is unknown.	25.00	25.00	263.00	262.80	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.42	0.70	-5.20	3	13	2009-01-15 18:05:59	2003-08-26 11:44:03	6	1	13	0	0	14	0	235.10	71	100.00	CHANGED	MSGKYcYAGLTKELHQRLVlEFsALKEcHsRTFTKHIMETKQCNRppARKYFQRFDNVIKERSKLSPuTLDDMREYLT-GLVNDLQEYLSEHYSAsSsSCKPDTsKTNAGLTEELF+QYRcEIcsLRAAHPNsFAsYIMEVKGCSpQQA+TIpTAINTIYTEIGILTPRKVIQLEGLLSRELFGKIAKYVFNKYEWPESLDSEVDRIYLEYRTKGDLGLEKESVKRALYKAIYMGL	.MK.+YEYAGLTKELHQRLTlEFDAL+EcH+R.TLTKYIMETKpCsRhpARKYFQRFDNVlKERSKLSPuTLDDMREYLTDGLsNDLQEYL.KpYosRsspC+PDsDKsNAGLscELFhQYRcEIppLRAsHPNshssYIM-VKGCopQpAsoIpTAINTlYTElGILTPRKVIQLEGLLSRELFGKIAKYVFNKYEWPESLDSEVDRIYLEYRTKG-LGp-KESVKRsLYKAIuMGL	0	0	0	0
+6896	PF07068	Gp23		Major capsid protein Gp23	Vella Briffa B	anon	Pfam-B_12245 (release 10.0)	Family	This family contains a number of major capsid Gp23 proteins approximately 500 residues long, from T4-like bacteriophages.	19.20	19.20	20.40	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	493	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.80	0.70	-5.97	4	1586	2009-01-15 18:05:59	2003-08-26 11:48:55	6	2	183	1	0	1357	2718	119.50	36	80.33	CHANGED	Ll-KWKELLEGEG..LPEIAN.SKQAIIAKIFENQEKDFpsuPEYKD-KIAQAFGSFLTEAEIGGDHGYsApNIAAGQTSGAVTQIGPuVMGMVRRAIPNLIAFDICGVQPMNSPTGQVFALRAVYGKDPlAAsAKEAFHPMYuPDAMFSGQGAA.KtFsslsAostTssGDIYp.HFFpETGosY...LQAohtVTIsutAssuthhDAEIhKQMEAGsLVEIAEGMATSIAELQEGFNGSTDNPWNEMGFRIDKQVIEAKSRQLKAAYSIELAQDLRAVHGMDADAELSGILATEIMLEINREVVDWINYSAQVGKSGMTphsGSKAGVFDFQDPIDIRGARWAGESFKALLFQIDKEAVEIARQTGRGEGNFIIASRNVVNVLASVDTGISYAAQGLAoG.FsTDTTKSVFAGVLGGKYRVYIDQYAKQDYFTVGYKGuNEMDAGIYYAPYVALTPLRGSDPKNFQPVMGFKTRYGIGVNPFAESohQAPuuRIQSGMP	........................................................................................................................tt.........................................................................................................................................................................................................................................................................................................................................................................................................................................th.......s........s....s....s..s...s.a.....scMuFoI-KhoVsA+oRAL.KAEYohE..LAQDLKAlHGLDA.EsELuNILo................................................................................................................................................................................................................................................................................................................................................................................................	2	0	0	0
+6897	PF07069	PRRSV_2b		Porcine reproductive and respiratory syndrome virus 2b 	Moxon SJ	anon	Pfam-B_13261 (release 10.0)	Family	This family consists of several Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2b proteins. The function of this family is unknown however it is known that large amounts of 2b protein are present in the virion and it is thought that this protein may be an integral component of the virion [1].	25.00	25.00	113.80	113.70	22.30	22.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.60	0.72	-3.69	2	55	2009-01-15 18:05:59	2003-08-26 11:57:46	6	1	6	0	0	55	0	72.30	84	100.00	CHANGED	MGSMQSLFDKIGQLFVDAFTEFLVSIVDIIIFLAILhGFTIAGWLVVFCI+LVCSAlLRsRPslHsEQLQKI.	.MGuMQSLF-KIGQLFVDAFTEFLVSIVDIIIFLAILFGFTIAGWLVVFCIRLVCSAlLRuRsAlHsEQLQKIL.	0	0	0	0
+6898	PF07070	Spo0M		SpoOM protein	Moxon SJ	anon	Pfam-B_13263 (release 10.0)	Family	This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH [1].	20.40	20.40	20.50	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.36	0.70	-5.00	9	513	2012-10-02 22:29:00	2003-08-26 12:03:17	6	1	383	0	138	438	6	209.40	36	81.77	CHANGED	FKKhLAShGIGuAKVDTlLppsslhPGtslpGpV+lhGGsssQ-I-pIpLcLss+Y.s.EscDsc...........sppshshspaplstuFsIpsGEc+shPFslslPapTPlTh.....t.chpVhlcTsLDIAtAlDssDhDhlsVcPpPhh-ulLpAl-pLGh+l+ps-sEps+h...GtpLPFVQEhEasPs.G.Y+t.hcElEllFhtssssL-llhElD++tpG.pGhLu-	.......................hKKhLAShGlGuApVDTlLpp.....tshhsGpplpGpl+lpGGsssQ.pI-pIplpLssphhh..E.s..s..Dpc.....................ht.p.s.hsltphplst.s.FslpsuE.p+plPFphplPh-.TPlTh.......s.ttpValcTsL...DIstAl.DPsDcDhlpVpP.PhhpsllpAlp.p.LGF+h+p..s-sEpu.h....htpp.l.P.F.hQEhEFhPs.utatGthcElElshl...h.s.s.c.tlc.llhElDR+......sGhh.....................	0	31	86	118
+6899	PF07071	DUF1341		Protein of unknown function (DUF1341)	Moxon SJ	anon	Pfam-B_14024 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 220 residues in length. The function of this family is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.50	0.70	-4.81	13	679	2012-10-03 05:58:16	2003-08-26 12:09:50	6	3	511	18	56	391	4	207.80	59	88.40	CHANGED	Y+sRVCLNVLAuSl-NAc-IY-AAEGHVLlGVLSKNYsoV-sAlsDM+cYsphl-NAlSVGL.GAGDPpQStMVucIScplQPQHlNQVFTGVGsSRALL...GQs-TllNGLVSPTGpsGhVcISTGPlSSp.ptcuIVPlETAIAhL+DMGGoSlKFFPMGGLppc-EYpAVAc.ACAccuFaL.EPTGGIDL-NFEpIlpIAL-AGVc+VIPHlYSSIIDpt	..................................................................Y+sRVsLNVLAtshpNA+-IY-AAEGHlllGVLSKsYsoV-pAVs-MKcYtAtls.u.lSVG.L.GAGDPsQ.thVucIutphpPpHVNQVFTGsG...h..oRuhL....Gtp-T..hlNuLVSPTGpsGhVpISTGPhSSp..ussuhVslETAIthlpDMGusSlKaFPMsGLpph-EapAVAp.ACA+psFhL.EPTGGIDL-NFtpILp...IAL-AGVp+lIPHlYSSIIDp.................	1	9	21	39
+6900	PF07072	DUF1342		Protein of unknown function (DUF1342)	Moxon SJ	anon	Pfam-B_14075 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 250 residues in length. Members of this family are often known as YacF after the Escherichia coli protein Swiss:P36680. The function of this family is unknown.	20.80	20.80	21.10	23.50	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.19	0.70	-4.68	63	930	2009-01-15 18:05:59	2003-08-26 12:13:27	6	1	924	2	168	466	123	206.70	50	83.59	CHANGED	LRLEtLhpplpthhstsct..hppchshpsLF-ll-lh-RsDl+o-LlK-LE+QpppLpsapshPslDpptLppllpclcpstssLhsss.+hGptL+-scaLsulRQRhuIPGGsCsFDLPuhHhWLpps.cpRpp-lppWhssltPLtpulsllLcLlRpouphpp.hApsGhaQpsh..pu...pLLRlcls.s..shaPpISGpKhthuIR	..............LRlEaLlpQLshslshsDp..ssslpFFRsl.-LLDVhE.Ru-.lRoELLKEL-RQppcLp.sWhsVPGVDQspl-uLlppLcssuusLhoAP.RlG.QhLREDRlluhVRQRLSIPGGCCSFDLPoLHhWLH.L.P.psQRcsplpsWluoLsPLspALohlLcLIRpSusFR.+Q.suhNGFYQcNus.-A...cLLRLpLsL..-..pplYPpISGHKsRFAIR......................	0	29	82	126
+6901	PF07073	ROF		Modulator of Rho-dependent transcription termination (ROF)	Moxon SJ	anon	Pfam-B_13280 (release 10.0)	Family	This family consists of several bacterial modulator of Rho-dependent transcription termination (ROF) proteins. ROF binds transcription termination factor Rho and inhibits Rho-dependent termination in vivo [1]. 	20.80	20.80	20.90	22.10	19.50	20.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.46	0.72	-3.97	31	733	2009-09-11 04:47:18	2003-08-26 12:43:39	7	1	727	1	80	248	6	74.20	59	89.79	CHANGED	.IsCcpYDYlElACh++h.lpLpL+sG-plpGpAh-htppt.....cKpEaLh.....................lcpp.uspptlcLDpIsuhsshp.sPcFuplhl	..PINCDDYDsLELAC.HHLhLTLpLKD...G.EpLQAK...AsDLlpR......KNVEYLl.....................lEs.u.....GEopELRLDKIsSFS....HPEIGTVVV.......................	1	9	26	52
+6902	PF07074	TRAP-gamma		Translocon-associated protein, gamma subunit (TRAP-gamma)	Moxon SJ	anon	Pfam-B_13437 (release 10.0)	Family	This family consists of several eukaryotic translocon-associated protein, gamma subunit (TRAP-gamma) sequences. The translocation site (translocon), at which nascent polypeptides pass through the endoplasmic reticulum membrane, contains a component previously called 'signal sequence receptor' that is now renamed as 'translocon-associated protein' (TRAP). The TRAP complex is comprised of four membrane proteins alpha, beta, gamma and delta which are present in a stoichiometric relation, and are genuine neighbours in intact microsomes.  The gamma subunit is predicted to span the membrane four times [1]. 	21.00	21.00	21.40	21.80	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.04	0.71	-4.73	9	147	2009-01-15 18:05:59	2003-08-26 12:49:58	7	3	109	0	80	132	1	154.60	62	87.79	CHANGED	EEELLLQDFSRNVSTKSSALFYGNAFIVSAIPIWLFWRlHpM-lhsShllFslhThsSTaLlAhAYKNsKF.LKHKIAh+RE-AVoREVspcL..uDDKKhoRKEKDERILWKKNEVADYEATTFSIFYNNALFLslllhuSFalL+ohsPohNYllShusAuGLlALLSTG	...................EE-LLLQDFSRNlSsK..SoALFa.GNAhIV.SAlPIWLaWRIapMDLh...p..S.ullaslhTLlSTYLlAFAYKNlKFlLKHKlAtKREDAVo+EVoRKL...ADs+K.MSR.KEKDE.............R...............ILWKKNEVADYEATTFSIFYNNsLFLslVIluSFFlLKNFsPsVNYIlSlusuSGllALLSTu................	0	30	36	60
+6903	PF07075	DUF1343		Protein of unknown function (DUF1343)	Moxon SJ	anon	Pfam-B_13635 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.	25.00	25.00	25.10	25.00	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.30	0.70	-5.61	109	613	2009-01-15 18:05:59	2003-08-26 12:52:12	6	11	514	0	245	629	524	355.00	36	82.47	CHANGED	VGLlsNpouls................t............shpp.........................slDhLhpt.sl...plptlFuPEHGh+Gs...spAGt.plssshDscTGlPlhSLY...................Gps...+.......................+PosphLc..s......lDlllFDIQDVGsRaYTYIsThthsMEAs.....................................uctshphlVLDRPNPhsGthl-GPlL-.ta............cSFVGhaP.lPhtHGhTlGELAphhsschhl....................................s....scLpVlshcsWpR.........shhasp.ssh.al.PSPNhPssposhlYPuhslhEG.T...........slStGRGTspPFp....lhGAPa..lc.s......tlhtthpt.t...l.GshapshtFpPp......hp+..apGchCtGlplp.l......s.pthcshpsuhhhlphlpc.hY............spphth.t..........th.......h.h-hLsGsspl+ptI.........ps.Gtshcc....ItppappclppFpphRpp.YLL..Y	...................lGLloN.Tuls.................p....p.h.pp.......................hl.DhL.hp....p......sl.....plsslFuPEHGhRGs..............spAGt...plss.thDs...p..TGlPlhSLY......................Gcs...+...........................+PsschLp..s........lDlllFDIQDVGsRaYTYIsThthsMEAs.....................................Ac..tsh.....p......hlVLDRPNP.sG..t..h..l-GPl.L.-..pa............pSFVGhhs.lPhhHGhTlGELAphhNsE.hhl..............................................................s....scLpVlshp.........sWpR.............sh.hast.tth..a....l.PSPNlPs.poshlYPuhsl.hEG..T...........sl.S.GRGTshPFp....llGAPh..lc...s.............thhtth.pt.t............lsGhtF.ps.htFpPt.........hs+....apuphCtGlplp.l...........s.pthp.s.h.c.hsh.h.hlphltc...hY..............spphtht....................th........thhDhLsGssplRptl.........pt..Gtsh..pc....lpptWppslppFpp.hRppYLLY......................................................................	0	119	188	224
+6904	PF07076	DUF1344		Protein of unknown function (DUF1344)	Moxon SJ	anon	Pfam-B_13761 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of around 80 residues in length. Members of this family are found in Rhizobium, Agrobacterium and Brucella species. The function of this family is unknown.	23.10	23.10	23.10	24.90	23.00	23.00	hmmbuild  --amino -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.68	0.72	-4.40	9	104	2009-01-15 18:05:59	2003-08-26 12:55:15	6	1	91	0	25	57	3	61.00	56	67.66	CHANGED	.As-sEGpIpplDpcuholTLDDGKTYpLPtEhch-uLcsGhKVlVhYspss.GcphlsDlp	....hApDsEGpITcIsKDocTITLDDGcTYKLPuEFD...luAlsPGMKVLIhYDlVD.tpRhITDIQ..................	0	1	11	14
+6905	PF07077	DUF1345		Protein of unknown function (DUF1345)	Moxon SJ	anon	Pfam-B_13768 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 230 residues in length. The function of this family is unknown.	24.00	24.00	24.10	24.20	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.08	0.71	-4.76	56	475	2009-01-15 18:05:59	2003-08-26 12:57:27	6	1	441	0	171	432	34	171.60	32	81.43	CHANGED	hshshs..hstplLlGWsssshlYLslshhhhhp.tsspclRcpApppDcstsllhhlsslus.......huSlsAIshtLssu+p.t...spshchslshsolhhoWhhlpshFulHYA+hYY...........ttstptsGLpFP...s............pppPcYaDFlYFSFsIGhTsQsSDVslso+phRRlsLhHullSFhFNoslLAl	..............................................................................hh....t..hthlluWsshhhlYLlhhhhhhhp.h.ss.ppl+phAtppDpst...hhlhhlshhAs.......lsSlsulhh.Ls...ssp..p.......sphhphslshh...olhhu.WhhltshFulHYA+hYY...........ttstttsuLpFP....t..................ptpPsYhDFlYFSasluh...ssQToDVslsopphR+ssLhpullSFhFNssllAh...................	0	40	93	132
+6906	PF07078	FYTT	DUF1346; 	Forty-two-three protein	Moxon SJ	anon	Pfam-B_13991 (release 10.0)	Family	This family consists of several mammalian proteins of around 320 residues in length called 40-2-3 proteins. The function of this family is unknown.	19.50	19.50	20.00	20.50	18.50	19.40	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.09	0.70	-5.12	2	70	2009-09-14 11:59:21	2003-08-26 13:00:14	6	4	40	0	32	87	0	230.00	53	92.94	CHANGED	RFuTRLhGATATPPP.PPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLQQSusRQFRMRVRWGIQQNSGFGKsSLSRRGRVhPGKRRPYGVITGLAARKATGIRKGISPMNRPPLSDKNIERYFPALKRKssLLRQNEVQRK.VAsLKRPNQLNRKNNIPsNFTRsGNKLSHQKDTRQATFLFRRGLKVQsQLNoEQLlDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKR-QSDlKKVPKGVPLQFDINSVGKQTGMTLNERFGILKEQRAsLTFsKGGSRFVTVG	...................................................................thshoLDDIIKLN+KE...t..p......+.........p.phsp..hp..R+.h.ppss....sp.......php...h.R.s.RW.GlQQ.pu.G.h..G+..stl.s..R....Rs+h..hP...GKRRs.GVITGLAARK.ssul+KGlSPhNRsPLSc.K.....shp..p.h....PhlpR...pss..R...ps-hQR...+............hs.lp+stthpR.p...............h....R.s........h..ptQ+-sR..QApFLF+R.G........LK.VQsQlp.tphhs...ss.pR...TRQW..RoSsssuGILTVSIDNPsAhp.....p..P.s.+s.RL...sRsshPsFlhK+-ps-.K.KlPKGVPLQFDI..NSVGK.QTuMTLNERFtILK-QRsshs..s+.GSRFVTVG................................	0	1	3	14
+6907	PF07079	DUF1347		Protein of unknown function (DUF1347)	Moxon SJ	anon	Pfam-B_14317 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 610 residues in length. Members of this family are highly conserved and seem to be specific to Chlamydia species. The function of this family is unknown.	24.00	24.00	24.30	75.50	23.30	23.90	hmmbuild  -o /dev/null HMM SEED	550	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-12.73	0.70	-6.30	6	40	2009-09-14 11:58:54	2003-08-26 13:26:39	6	2	37	0	7	25	0	547.60	57	85.61	CHANGED	spQQ+.tLLCFQGFlLQKQ+phpQSEcIFSKIYcEhpsu.FlhKEElLGGRILNAFFL-NI-hM-hllspLcQpsupSsYLsLFcsLlsYKQKpacpAlpsLShWpsplcpocssLLDlNIppLhSDFlL-sIpAHSLIEhGcFuEGRsILNRIIcKlLKREssWsu-sYDphVLMLSRSYFLELppSppscIYPDYYEMILFYpKKl+ulDQpuYccFlPp-ELhShlM-HlFVVPc-+LsPLMQllchWE+aYhsPNYsLVlcsLlc+Fhosspplt+lCpuIss.c.IEpLKc+LI-sFuclLStpVpplpTscApQsLuLLKILDsslShSEKLllSscsLpcIlupDDtpaTpL+cYLsLWEpIQSYDlDRQQLVHYLhhuAKpLW+pGssD-KALNLL+LILpFTsYDIECENlVhLFlKQsY+QsLStHuhsRLLKLEDFIo-sGLTsIsluEtEIANFLADAEaLaupG-Y+KCYlYShWLTKlAPSs.sYRLLGLCLhENKpYpEAW-hLppLP.NcchaDSKVQKALlLCQKHlsKDhtso	........pQpphYlLCsQGFoLQhQ+KFQESEcIFSRIaccpsSuPFlLpcELLpGRILNAYFLNNLsLMscplsELE+hsG.spsaLhhFKALaAY+sKpYchAl-sLSpWhu+VcpTcshhLDTNl.cLFSsalLEcIuA-SLIts+RauEGRlllNplhNKlFsREasWssDhYNRlVLMLGpSYLLELpEuspuDLhP-YYEhILFYpKph+uhDttAYcpFhPEs.LVsTIMQHlFVlPEspLPhaMphLhMW.ENpYVHPcYSLVlEphcstllp.Du.csp+ICpAIAcS.K.Ic+LKE+LI-hFu-.LshsVpQspTlpAcQYLALLKhLDPcsS.hu+KL..LLSpKplhNhVCpDDuQYo+LKDYLhLWEEt-.tDVDRQQLVHYLhauAK+LW+tGQ.-EtsLcLLKtILhFopp-h..tC.NpshchVKahYsQALuh+shT+LlhlENFl-EVGLPphlsS-AE.IANpLADApYLFu+GDY+hChlYSSWLs+VAP.SscAhpLLGLsLhEpK-YsEALEshpcLP..sE-hasSpVpKA.lLC.Kalu+ppcpp...............	0	1	2	6
+6908	PF07080	DUF1348		Protein of unknown function (DUF1348)	Moxon SJ	anon	Pfam-B_14137 (release 10.0)	Family	This family consists of several highly conserved hypothetical proteins of around 150 residues in length. The function of this family is unknown.	21.10	21.10	21.70	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.74	0.71	-4.39	7	617	2012-10-03 02:27:23	2003-08-26 13:50:36	6	5	563	4	278	595	44	138.20	62	88.57	CHANGED	RPPLPPFTtETAhpKVRhAEDuWNSRDPs+VuLAYTpDShWRNRuEFhpGR-tI.tFLoRKWp+Eh-YRLIKELWAFsGNRIAVRFtYEW+DDuGpWaRSYGNENWEFDEpGLMp+RcASINDlPIuEu-R+a+W.sLGcRPsD	................................RPPlPPF.T.t.EoAhpKVRhAE.DuWNoRDPp+VuLAYTsDSt.W.R....NRuEF.lsGRpcIhsFLpRKWp+El-YRLIKELWAFs..sNR.............IAVRFAYE.W....H......D...D.u.G....p.WFRSYGNENWEFs.c.s....GLMp+RaASINDlPIpEu-RhF+W...P.Gt.RPDD...........................	0	67	157	220
+6909	PF07081	DUF1349		Protein of unknown function (DUF1349)	Moxon SJ	anon	Pfam-B_14150 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins but contains one sequence (Swiss:P40893) from Saccharomyces cerevisiae. Members of this family are typically around 200 residues in length. The function of this family is unknown.	28.00	28.00	28.80	28.40	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.08	0.71	-4.93	37	701	2009-01-15 18:05:59	2003-08-26 13:54:08	6	18	553	4	274	639	31	174.40	25	72.45	CHANGED	pWhNcPtpaphss.ctlplsTssp.TDFWppTaYGF..ppcsuphlhhpspsc.F.ohpl+lps.sapshaDQuGLhlhlD-c......sWlKsulEa.sDGhspluoVVTp.shSDWuss.h...ssscphahRloRpssshplph.ShDGppaphlRlsh.a.................sspshplGhhuCSPp.psGhpspFs-hplsss..psh	...........................................hh.p.P.t.hphp......p...ptlplps.tsp.TDhWpc.....o..h..Y.u..F.........ptp.s......u.........h..h......h.....hp.h.....t..........s...........s..F..phplplph...sh..p...p..........haD..QuGLhlhh...sp.p...............................pWlKs..ulEa.....s-uhs...p.lu..oV.l.Ts.....s...hSD......Wu.sssh.................sss..p.....p..h..h.h...RlsR....p....t..s..s.......h....tl...h...u.h...-.............u...........p.p.ap..h...R.lsh..ht.........................tsp..shp...lGhhsss.P.......p......ppG......hp...sp..Fpphplp.......h.........................................................................................	0	73	157	225
+6910	PF07082	DUF1350		Protein of unknown function (DUF1350)	Moxon SJ	anon	Pfam-B_14167 (release 10.0)	Family	This family consists of several hypothetical proteins from both cyanobacteria and plants. Members of this family are typically around 250 residues in length. The function of this family is unknown but the species distribution indicates that the family may be involved in photosynthesis.	21.70	21.70	21.80	24.50	20.40	21.60	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.63	0.70	-5.31	3	176	2012-10-03 11:45:05	2003-08-26 13:57:17	6	3	104	0	94	183	162	222.70	31	76.11	CHANGED	EW+EIRGNWVLVPppPlGlIHFLGGAFVATAPpLTYRWLLEcLGcAGYVVIATPFVNTFDHtAIApSVLN+FEhsLERLp+pGulssuhLPlYGLGHSMGCKLHLLIGSLY-VERAGNILlAFNNYPAKQAIPa........lDpFsTul.............ulEFTPSPpETN+LIQEsYsVRRNLLIKFsNDDIDQTAuLRsILps+FuDMVTApsLPGNHLTPLGQDlKWQTGuEFSPLDALGQWlKQSLapDLspLp+slLcWLNP	.................................tts.ahhhP.......p....Ph...ullcFlGGuFlus.s.PploY+hhLEpLu.p.p.G.a.hllAsPa.ss..s.....FDH.thAppl...ht.p....Fc.p.......s...h.p..tL.....p........p.........................h................t........L...P......h......a.......u............lGHShGshlHLL..l..........s.s...........h...h....ss.....p......+...s.......us..lhhuFNN..hssppulPh...........................hp..ph..s........h......................................................................t...EFsPoPpE.....T.pl.lpp...Y...t...hpps..LLl..+FpsDpl.D.po..L..ph.Lp..t.......c......s......s..h.......h..p......hh.Ls.GsHhtP........htt.....................................................................................................................................................................................................................................	0	29	65	86
+6911	PF07083	DUF1351		Protein of unknown function (DUF1351)	Moxon SJ	anon	Pfam-B_14178 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 230 residues in length. The function of this family is unknown.	21.60	21.60	21.60	22.50	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.18	0.70	-4.71	14	177	2009-09-10 23:43:51	2003-08-26 14:05:05	6	2	167	0	23	155	3	211.50	23	68.34	CHANGED	p-lp..lphpPApIp.hshEphcpplsplspcY.pshlVTs-shppcKpphAcLpKltKslsccRhclc+phspPhs-F-thhK.plhp.lcsslspIspslK-h--+p+p.+hcpl+thlschsschtl-tp.hcph.....hpssahssshshKK.lhcplcphlptchpchpphpsscpsIppt.........stp.....slssssYlchLcp.psls-lhsphcsD....h-hp+pp	....................php..lphpsutIp..sh-plcptlsphlscY..psh..h...sT...s..-slp-sKp...sRAcLN....Kltptl-spRKclK+phscPhc-F-pplK.c.hh...t..lc.pshspIspslKpaE-pp+ptRhcplpthlschstpht..lsh.p.hc.h.........hpspahsc.....sh......shKK..hhcc....lss...hh....tt...hpchpphcpspphlpph.............stt.............hshss.sal.phlcp...shs-lht.hcps....h.h...................................................................	0	7	16	21
+6912	PF07084	Spot_14		Thyroid hormone-inducible hepatic protein Spot 14	Moxon SJ	anon	Pfam-B_14186 (release 10.0)	Family	This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesise triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression [1]. Spot 14 protein is thought to be required for induction of hepatic lipogenesis [2].	19.80	19.80	25.40	21.00	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.01	0.71	-4.36	10	191	2009-01-15 18:05:59	2003-08-26 14:17:21	7	4	83	1	106	186	0	134.70	30	90.42	CHANGED	MQls.DohspKpSLhNAMNRFluAVNNMDQTVMVPSLLRDVP....Lsppstc...............phpssss......ts.h.stpsDMYsaYlLLKSIRNDlEWGlL.+p......u..Esst+cc...ssssutsscEs...s-tDLEpQFHYHLpGLHoVLSKLT+KAspLTNRYKcEIGhushup	.........................................p....KpslhssMpRahusVpsM-pTlMlPSLL.RDl.l.tptt.p......................................................t.ttDhYphY.hLKu.I+s-l-aG..............lh....pt.......................t...p.t.t..ppp..................p...s...tt.pt...ttp.-L....E...tpF+hHlpGLaplLscLTppAp.LTp+Ypp.hG......t...............................................	0	22	32	69
+6913	PF07085	DRTGG		DRTGG domain	Bateman A	anon	Bateman A	Domain	This presumed domain is about 120 amino acids in length. It is found associated with CBS domains Pfam:PF00571, as well as the CbiA domain Pfam:PF01656.  The function of this domain is unknown. It is named the DRTGG domain after some of the most conserved residues. This domain may be very distantly related to a pair of CBS domains. There are no significant sequence similarities, but its length and association with CBS domains supports this idea (Bateman A, pers. obs.).	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.00	0.72	-4.43	171	2967	2012-10-03 03:17:47	2003-08-26 14:50:23	7	34	2600	6	655	1966	228	107.60	30	20.44	CHANGED	-lsctLsucllsusptttcp.lpchhluAMshpshlphlct.....sslllssGDR..sDl.luAltss.......huulllT.Guhpsssplhclscptt....lPllssshDTassuphlsph	................................................................-lschlsupllsss.-th...p+c..lpphsl.u..Ahs...l.p...s...h..lc..a...hcs.............GsLlls.uDR....s-.l.hlsAhhss..............huulLlT....G...G...ac....s....s...sclhcLscctt..............lPllpss...hsTapsuthlpp..................................	0	237	457	587
+6914	PF07086	DUF1352		Protein of unknown function (DUF1352)	Moxon SJ	anon	Pfam-B_14369 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 190 residues in length. The function of this family is unknown.	22.20	22.20	23.00	22.70	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.35	0.71	-4.66	10	145	2009-01-15 18:05:59	2003-08-26 14:54:03	7	3	112	0	88	133	0	171.20	36	94.47	CHANGED	MASRuGPRAuGTDGSDFpHRERVAuHYQMS.....sshKSElKKLIhlHhLIWlLlsApluVupL........tLlS+cpVuhPYQWEYPYLLSllPSllGLhuhP+NpISYLVlSMIStGLFuluPLlYGshthFPtupcLa+HGKAhchhhshoAls.............lMYllhVlAlQVHuWQlYYSKKLLDuWhssTpcKK++	...........MASRu.G.sRsuGTDGSDFpaRp+VAs+YQhS..........sphKuclKhhl.....hhHhllahlhhA+.lssshL................hh.lpc.pls.Ph.W.E...Y..s.ahl..SllsohlGlhuh.RNplshLhh.h.l.uhhlhul...hPllau.h...hhsts.phhppscu.ch.hs.shs..............lhYhhhhl...uhQlHsa.plY.auhpLlpuWhststtc.......................................................................	0	29	41	64
+6915	PF07087	DUF1353		Protein of unknown function (DUF1353)	Moxon SJ	anon	Pfam-B_14433 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.	22.50	22.50	22.50	22.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.30	0.72	-4.52	35	353	2009-01-15 18:05:59	2003-08-26 14:55:52	6	3	263	0	55	251	186	91.10	36	62.82	CHANGED	pacLhps..........hhhpssu.....hhhhVPtG..ap.TDhASIP+hhhslh.sPa.ucYhpAAllHDaLhspt........................ths+cpADplFhcuhtshG..Vsth+thhhahAV	..........................................aclhps..........Yh.p.ps....hl.VPtG.....Fh.TDhAS....lPRl......F.W......s.lh..PPh....GcYhpAullHDaLhcps..........................hps++pADhlFh-uMphhG..Vs+aKthlhYhAV.....................................	0	14	33	45
+6916	PF07088	GvpD		GvpD gas vesicle protein	Moxon SJ	anon	Pfam-B_14302 (release 10.0)	Family	This family consists of several archaeal GvpD gas vesicle proteins. GvpD is thought to be involved in the regulation of gas vesicle formation [1,2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	484	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.68	0.70	-6.18	5	21	2012-10-05 12:31:09	2003-08-26 15:10:38	6	1	15	0	11	437	87	367.10	29	79.27	CHANGED	lcRFFsG-sG+TLLINGAPGTGKTLFTIRGLDVLcR-uDVLYVSTRVDQ-TVaEMY......FcsHuSLD..KTulL.............DLhQDPFtLPhDVDVPFEpLsL-SLLEWVDtIsAsuc+LTIAFDSWcLlYEYLAsRHDsPPD..IcTVTNQLVsLARsuGlRLlLVoETAssSsLEYIVDGVVTL..pVK-D-RGRTRRsLRLEKLRGVRIGNRLQP...FTLADGQFpuITPVELlTscTssspuTWEPts.NssA+FSTGIGDLD..+ILSGGaNR...GSVVHLDLGsDLSRDAWSVLsLPAIRNFLupEMGVAVVPP+EGSPGLLHNDL...NsVLo+uVFDTaCHVFETYAGPo+ut........stpaLsshhTso.SDAlsP.......................stlssp-........asoPlEGGpLcYDPYhEhlEplRcQS-GPLLHVISMDTAapAFETRLGDFANYVA.....LHNDusILITKsGTtLRTRADRVADMHFRLEp.SG-AIsLYGENPLTPLLGIGlccSpsIPKIpLTEMV	..............................................................ppFFptcsGpoLLI.pGtPGTGKThF..o..lc.h.L...s...s...l.p..c..c..t.s..s.h.Yl.S.....T.R.V.s.p.-.sl.a.cha...............h...ct.t..ls............ht..ll...........................c.h.p..p....D.....h..t.....h.........h...t....h...s....l.....Ph.............h...s......l....-.s....l...h...p.a.l....c.p...l.s.s....t...s..c.p...s.....hl.s.lDS...W.....h..lh-h.L.u.s...c.a.ssspc.......l...cslp..s...pLs...........h.....h...c.....c.t.s.....s.+..L...l...l....V......h....E....s....s...c......p.......p.....s........L.........-.....Y.ls.DGVVoL...........phc......ps...p..G.R.hh...R.LpL-KLRGlpIpppha....FTL.t..s.G..pFp..s..hss.s.p.h.h.spp....h.hcPhs...ss.pscaSTGhtDhD..pIhsGGhph...GShlhL-hspsls.pha.hls.h.shtNhlp.thtshll......................................................................................................................................................................................................................................................................................................................................................................................................................	0	6	9	10
+6918	PF07090	DUF1355		Protein of unknown function (DUF1355)	Moxon SJ	anon	Pfam-B_14563 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 250 residues in length. The function of this family is unknown. THe structure of this domain was solved by the Midwest Center for Structural Genomics (MCSG). The structure has been classified as part of the Class-I Glutamine amidotransferase superfamily.	24.40	24.40	24.50	25.00	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.27	0.71	-4.90	13	830	2012-10-03 00:28:14	2003-08-26 15:19:49	6	10	622	13	194	554	141	168.00	35	34.26	CHANGED	+VLllG.ESWstphpHhKGFDpFsol+acpGAchLLpslcsushclcaMPAHp.utpsFPhsh...EpLssYDsllLSDIGuNThLL.stsahc.p.sPstLcLl+-YVspGGuLlMlGGYhSFpGIpu+Apa+pTPlt-VLPVs..........sLshDDR.......VEhPpGhtspshu..cHPlspGLus......-W...P.lLGaN...cl	............................................................+VLhlu.tp.H.t.hp.+.s..h.............K.-.tu.ssh.lh.slhp.s.s...c..D..hhPscp...s.hsFPpsh.....-pL..spaDsIllscluusshL...................sstLc.hI.t.cY.V.p.p.G.Gu.LLMlGG..SF......upusappTs.Lu.-VLPVp.............h.s.ss..cp............lE...pP.....tsp..hps.h..u...cHPlspshs........................ca...s.hhth........................................................................	0	79	129	155
+6919	PF07091	FmrO		Ribosomal RNA methyltransferase (FmrO)	Moxon SJ	anon	Pfam-B_14605 (release 10.0)	Family	This family consists of several bacterial ribosomal RNA methyltransferase (aminoglycoside-resistance methyltransferase) proteins [1,2].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.60	0.70	-5.39	14	272	2012-10-10 17:06:42	2003-08-26 15:26:17	6	1	225	6	8	986	235	174.10	50	65.63	CHANGED	uutKYRslsPssVcRlspcth.spptshtpshKtsKp+LHplhGAal..tts.htthL+pltp.....sssssD.puhpsh.t............t....hhuhHuST+ERLPh..LccFYsplFutlss.PsoVhDlACGLNPLAlPWhshssss.sYhu.DIDpshh-hlsshLshlssttpsplp..Dllss.ssssssDlsLlLKslPsLEpQctGuuhcLlctlsu.hlVVSFPT+oLGGRs+GMtpsYstthEuhsstcsap.hpchphusE.Llal	...............................................................................pphsshcp.cccuphh..........................................................KuLQhl...oApCVKQVEVIRA..R....................R....LLcGpAST...o.....GY.F-N........IEH..C.I....DE....E..FG..p...s..o..l...N..D...K...LLLlGS..G....A..Y..PMTLIQV..A.K.E.T..GA..SV....IGIDIDsQA.V.D.LGR..R..I.....VN.V...L...A........P...N...E.......D..I.sIo........DQc.V.u.....p..L..K.D..I.pD.V.T...a........................................................................................................llhppshsh.........................................................	0	6	7	8
+6920	PF07092	DUF1356		Protein of unknown function (DUF1356)	Moxon SJ	anon	Pfam-B_14617 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.	22.00	22.00	22.00	22.00	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.18	8	192	2009-09-13 19:50:27	2003-08-26 15:34:03	7	5	60	0	95	173	0	197.30	43	86.84	CHANGED	pED..............ps-chLsccspptsIuQFPYVEFTGRDSlTCPTCQGTGcIPptQ.NpLVALIPYSDQRL+PpRTKLYVhLSVlLCLLsSGLVlFFLFPRSVhVsssGlKSVpVsFscpsphVhLslTuoLNIoNsNFYsVpVsslouQVQahKsVIGptphoNlohItPLup+QlsaTVpsclusp.oYhYhaCTlsoIKVHNIVlaMQsoVphSYhuHspQsolEoYcYVDCGuNoT	..............................t...................t.t..spttppt.huphPh.chsG.p.sul...TCPTCQGoGcIPp..tpcspLVALIPauDQRL+PpRTKLYV.hhu....VhlCLLhuuLs..l......FFLFPRSl.Vp.s..G..lpss..hVs..as...........tpp....l.hLslTshLNIoNsNaYsltVps...lospV......a......p.sVlGphph.ssh...Is.Ph.s.p..h.asl.s..h...ttt.....o..ha...hCTh.pIpVHplllhhp..solph.oYh.uH.pQ.s.ppapYVDCttNso.........................................................................	0	19	29	50
+6921	PF07093	SGT1		SGT1 protein	Moxon SJ	anon	Pfam-B_14698 (release 10.0)	Family	This family consists of several eukaryotic SGT1 proteins. Human SGT1 or hSGT1 is known to suppress GCR2 and is highly expressed in the muscle and heart. The function of this family is unknown although it has been speculated that SGT1 may be functionally analogous to the Gcr2p protein of Saccharomyces cerevisiae which is known to be a regulatory factor of glycolytic gene expression [1].	27.00	27.00	28.50	27.10	26.80	26.80	hmmbuild  -o /dev/null --hand HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.94	0.70	-6.13	33	327	2009-01-15 18:05:59	2003-08-26 15:46:34	6	13	251	0	233	314	3	469.20	23	84.08	CHANGED	sVcYpla............t.tsspsphpplpphhtclhscls.hh.....ps.YIWQ.+-sFpLphpptp....................sssaltGpTpa.GDsl-D.EWaIVaLLhclo+pa..sslhs+VhD.sDGEFLLIEAAchLPcWLsP-supNR.VaIppGcLpIIs............t.spt.spslolppAlphlp.spsp.thhtSsplpsslppR.lcsY..Pcp.lppsl...HcAplhlPtplAtlL+p..cPpLlusAVpAFYhR..DPl.sl+.....sspshphF.....................Pcsh.VpsoVpFT+s.L..YAQLhpQpFs.Psph........................hthPssscs..tactt-.......LGhKL............................usGFEhLhspsctptpssp...........ss.thpshLcsLpcsGhhp.s.l.sspchpphhp.s............................................................................t...t...spDDDsWLs.ls.--L-p.Lpp....+ttpppthp.spppp.....s.....................................sLpclspphpsFlsc.tusa-Gs......-h.................................................................................................................................................................................................spsspcpslsh........D....t-pFhc.hhcchLshsss-.ss..s..............................sshtc.csp-s-sps--.............t.p............stpplpphhppM-pELttoshhp.....................stttpt.pstsp............................tptsstsp.t.....pslDlD	..........................................................................t.lpp.h.phht....h.............tYlWp.ppshp..lphh.tp........................................h...hlh..G.hhpa.GD.slcD.EWhlValLhplocpa....splhh.+...l...D.sDGE..FLLIEA..Aph.LP..pWl.p..P.-.s..........s.pNR.V.alppGpLtlls................................................sps..sl.pAlph..lt..spst..thht.........sttlptth.tR.lpt..a.....Ppp...hpp.sh.........HpshshlP.tt.l.u.tlLcp..pPphlu.AlpuF.h.R..Dsh..sh+......................tspt.h..hF........................................................s.p.ph.lhsslphT+s.h..YApLh..pp..pa....ss.....................................hs..tp......thtthp.................lGhKl...........................................................spGhEhlhp...p.t.pptt...........................................s..ht.hhppL.pps..t....l.sst.ph.phhp....................................................................................................pDs-pWhp.hs.pph.-p.Lpt.............t.tt.t..t.tt..t....................................................thtphspphptFlpp....us...hcGs.......c..h...........................................................................................................................................................................................................p.p.pt.hph...................................-.......ppF.p..hhcph.hs.......tt....tt...........................................................................t..t....p.tt............................................................................................................p.tthpph.tth-tELtttth.p...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	80	131	195
+6922	PF07094	DUF1357		Protein of unknown function (DUF1357)	Moxon SJ	anon	Pfam-B_14833 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 225 residues in length. Members of this family appear to be specific Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	21.90	21.90	22.20	40.60	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.43	0.70	-4.90	3	130	2010-01-12 09:55:36	2003-08-26 16:05:37	6	3	27	0	10	107	0	192.30	66	94.63	CHANGED	MpsKE-pEDSpclsSpsspV..psDsllISApEFEEY++aK-psNscSKtoH+DLSINERlo+ELAEVpEREulpcpLLhEApRINEIDTLAscaLSNHFNKEsLLAKGYSLKEIlpAQuRELIRKYVssEQIKAIAKVssl-HIDGchLEQLlcLAKVNIKQRKNAEsNa+olsplRsNh.VKhcE+sSLpNSNFhPIN+TELscAM.Npacph+IQFYpNpK+	................hhEcEEKEDLpsQsK--pQl..KuDTKVISspEFEEYh+hKEQu.N......s.K.....s.K.EosRDLSINERITKELAEVEERERlEKQLLLEAERINEIDTLAKAHLSsHFNKEsLLAKGYTLKD.IMQAQRRELVRKFVPIEQIKAIAKsSDISHIDGEILEQLVSLAKVNIKLRKNAsSsSSSVDuIKGNIhhKSEERsSLLDSNFVPINFTEFVQAISNTYKQRRhQFYENLKR...........	0	5	5	5
+6923	PF07095	IgaA		Intracellular growth attenuator protein IgaA	Moxon SJ	anon	Pfam-B_14923 (release 10.0)	Family	This family consists of several bacterial intracellular growth attenuator  (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria [1]. 	25.00	25.00	26.10	31.00	23.70	21.20	hmmbuild  -o /dev/null HMM SEED	706	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.52	0.70	-13.02	0.70	-6.78	10	600	2009-09-10 22:06:59	2003-08-26 16:21:33	6	1	546	0	41	315	4	641.80	75	99.32	CHANGED	MSTIVllLAhlLAClllsGhhlth+tR.R+.tlshh.uFucsTsRKLTu-ERuAIEsYL.pp.sp.......hhsoPssouuoussspLsLsspSDsVYslT+AITRYGlooD-PNKWRYYLDSlEVHLPPFWEQYIs--NsVELI+TsSlPLVISLNGHoLp-ahp-ts.u.sLppsuss.....pASIRpEESEplELLNIRKET.EE+ALs+PsGl+EAsLIsAuFLLaFFuLloPsVhlPWLsusAlLLluhGLWsLFpPPucssLRElHCLRGTPKRWGLFGEssQGQIsNISLGIIDLIYPsHWQPYIApDLGpKTDIDIYLNRQVVRQGRaLSLHDEVKNFPLQ+WhRNhllsAGSLLVLlLLlhaVPLslPlKLoloWL+GAQTlElToVspLEcAtLRlGDTL+spGTGMCYl.sPsp..hSsppsosFhPFDCSuIYWNsAsPLPlPES-Tl-KAoALlpoVN+QLHPp.-s-s+VNPsLuSAIQKSGMlLLDDFuDIVLKTQDLCss-.sDClRLKNALVNLGNsKDWsoLVKRAcuGKL-GlNVLLRPVSAEoLEsLVsooTusFlhRETs+AApuLNSPPPGGFLItSDEGKQLVspPhPsl......sLaDYsuhEQWpELQRLusMLLHTPFpAEGIlTslsTDANGTpHIsLHS.PDpsoLWRYlGTTLLLLshlsshlaNuVhslRRhp+sRpRhp-IQ+YY-sCFNspLhPss....c	...................MSTIlIFLAALLACSLLAGWhh+V+SR.R+.pLPWssAFsDAQTRKLTPEERSAVENYL..-.sLoQ........lhQVPG...P..TG..A..SA.APISLs.LNAESNNVhhLTHAITRYGIoTDD.PNKWRYYLDSVEVHLPPFWEQYINDENsVELIhTDoLPLVISLNGHT.L.Q..EYM.QEoR..GYALQs.ssST.........................QASIRGEE.SEQIELLNIRKETHEEYALSRPpGLR..EALLIVASFLhFFFCLIT.PDV..FVPWL.sGGAlLLLuAGLWGLFA.PPu..K..............SuLREIHCLRGTPRRWGL.FGENsQEQIN.NISLG.IIDLlYPAHWQPYIuQDLGQQTDIDIYLD.R.HVVRQGRaLSLHDEVKNFPLQHWLRSTlIA.uGSLLVLFM..LLFWIPLDMPLKFTLSWMKGAQTIEATSVKQLscAGVRVGDTL+lSGTGMCNI+ouuT..W.S..u.po..NSPFhPFDCSQIIWN....DApuLPLPES-LVNKAsALopAVNRQLHPK.PED...-....SRV......S..ASLR......SAIQKSG.MVLLDDFGDIVLKTADLC.......SAc.....DDCVRLKNA.....LV.N.L....G.NSKD....WsALVK..RANAGKLD..GV..NVLLRPVSAESL-NLVsTSTAPFIo+ETARAAQSLNSPAPGGFLIsSDEGS-hVDQPWPSs......sLYD.YPsQEQWsAFQ+LAQMLMc...TPFsAEGIVTpIaTDANGTQHIuLHsIPD+SGLWRYLuTTLLLLsMlsSAlYNGlQAaRRYQRHRTRMhcIQtYYESCLNPpLhss.p...................	0	1	9	24
+6924	PF07096	DUF1358		Protein of unknown function (DUF1358)	Moxon SJ	anon	Pfam-B_14731 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 125 residues in length. The function of this family is unknown.	20.90	20.90	20.90	21.50	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.51	0.71	-4.44	5	99	2009-01-15 18:05:59	2003-08-26 16:24:23	6	4	80	0	65	112	0	110.40	41	68.73	CHANGED	MtothspsGpossu..psssu-cERKFRl+GGAFLGsVAusuAlAGFS+TLuhAKKuDPcaF.sKGlpuolAL.EoGoSLALRALGWGTLYAaLGTGsICFGlWKLoGA+sMpEFRpKMGoIFPRI	.............................................tststcc+hFhlpuuh..FLGsVuusuhLuGFspTLuhAKKpsPcaF.s+Gsh..ustuL.EoGuoLALRALGWGoLYAhsGsGllsaulWKhhGl+shp-FR.KMtshhPtl...............	0	23	29	44
+6925	PF07097	DUF1359		Protein of unknown function (DUF1359)	Moxon SJ	anon	Pfam-B_14784 (release 10.0)	Family	This family consists of several hypothetical bacterial and phage proteins of around 100 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this species. The function of this family is unknown.	25.00	25.00	133.60	133.50	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.30	0.72	-3.97	2	9	2009-09-11 08:58:17	2003-08-26 16:27:01	6	1	6	0	3	4	0	98.10	68	94.24	CHANGED	M.pEhpl..pcpItphppKhsRLpplIHtl+pQ....cll.DchpsscIppssKFthpLs...uhhcsshpIsVGTLIsLLcpNIEsNTslhsELstcLGI-lc	MsQEITlDFSEQIAKsQTKIsRLKchIHcVRcQ....KIVLDDlKNNHhs+DTKhELNLG...GVLKCSVKINVGTLIPLLEQNIEDNTsLIpELAKELGIDIK	0	3	3	3
+6926	PF07098	DUF1360		Protein of unknown function (DUF1360)	Moxon SJ	anon	Pfam-B_14863 (release 10.0)	Family	This family consists of several bacterial proteins of around 115 residues in length. Members of this family are found in Bacillus species and Streptomyces coelicolor, the function of the family is unknown.	20.90	20.90	21.10	21.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.37	0.72	-4.31	21	265	2009-01-15 18:05:59	2003-08-26 16:44:47	6	1	226	0	60	183	34	103.80	37	75.40	CHANGED	llslAoaRLTRLIVaDpITsalRpPFhcptcph..p.GpsEshhss+u..stlRphlGELLSCYWCTGlWsAshlhhualhhPchsp.llhlLuIAGuAul.lEshlu+	...........................lhsLAsaRLTRLIVaD+I.TuhLRpPFhcc.......hc.......hs.......-........s...Gsspshpt.s+u....pulR.phlGEL..LoCaWCsGlWlushlh..ss..h...sal..P....phupsl..lhlLAlAGuuul.lEshhu.h......................	0	16	41	49
+6927	PF07099	DUF1361		Protein of unknown function (DUF1361)	Moxon SJ	anon	Pfam-B_14870 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.	25.00	25.00	26.30	26.30	21.30	23.70	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.28	0.71	-4.43	31	569	2009-01-15 18:05:59	2003-08-26 16:47:59	6	3	546	0	84	337	14	166.00	36	79.45	CHANGED	lWNlFLAhlPhtluhhlphh+sp........hlhhlhsllWLlFhPNA.YllTDllHLp................hhtshsht.ahthhhlhsushhulhhGhhShhhlhphhpph........h.thhlhhslhhLsuhGIYlGRFhRhNSW-llspPpsllpplls.l.....ptcthhFllhhshl.lhlh	.................................hhNlFLAYIPhELu...lLL....phhK.p....................h.lahlh.uhlallhhPNs.YhlTDLlHLp............htashhh.shshspWhhFsh..Llhulhhulhlshhsh..hpl....hp..h...hppp...........hh...phlllssLhaLsuhGIYIGRF.........hRLpShalhs.pPhpllpclhpsl.....shc.ph...hFlhhhshhQhhl.h..........................	0	25	59	75
+6928	PF07100	ASRT	DUF1362;	Anabaena sensory rhodopsin transducer	Moxon SJ	anon	Pfam-B_14972 (release 10.0)	Family	The family of bacterial Anabaena sensory rhodopsin transducers are likely to bind sugars or related metabolites. The entire protein is comprised of a single globular domain with an eight-stranded beta-sandwich fold. There are a few characteristics which define this beta-sandwich fold as being distinct from other so-named folds, and these are: 1) a well conserved tryptophan, usually following a polar residue, present at the start of the first strand; this tryptophan appears to be central to a hydrophobic interaction required to hold the two beta-sheets of the sandwich together, and 2) a nearly absolutely conserved asparagine located at the end of the second beta-strand, that hydrogen bonds with the backbone carbonyls of the residues 2 and 4 positions downstream from it, thereby stabilising the characteristic tight turn between strands 2 and 3 of the structure.	25.00	25.00	28.30	30.40	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.55	0.71	-4.37	25	78	2009-09-25 12:58:53	2003-08-26 16:50:45	6	2	67	25	33	77	31	117.60	44	90.17	CHANGED	slGc+pWsIs-GYIPspSsGsp.thsSHEslClLNsuDc-A+lplTlYFsDR-PlGPaclsVsuRRThHlRhN..-L.-PpsIPpsssYAsllES-VPVVVQaoRLDoR.QuphALhoTlAYss	..t.lGcppWsIs-GYIPspSsGs.............hsSHEslClLNsuDpsAclclolaFpDR-PlssaclsVsARRTpHlRhs..-LtcsEslPpsssYAhllcSDlPlVVQaoRLDop.QuphALhoThAYs.s.....	0	12	23	28
+6929	PF07101	DUF1363		Protein of unknown function (DUF1363)	Moxon SJ	anon	Pfam-B_14992 (release 10.0)	Family	This family consists of several Trypanosoma brucei putative variant specific antigen proteins of around 80 residues in length.	19.50	19.50	23.20	85.50	17.70	17.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.05	2	14	2009-01-15 18:05:59	2003-08-27 09:26:29	6	1	4	0	0	11	1	102.00	73	95.07	CHANGED	MSRHGNIDIGCGAGNTMDATFRSCTPHESFYYLSINHDLKAREAQNNNTNSDTICFSTHLHKRSNRRLDRRCEYIFGICSIKGNSAARRKKFLpTPLCQRYlNNCLKYMHSICHYQTRPGRTSS	..................MS.cGNIDIGCGAGNTMDAsFRSCT.HESaYYLSINHDLKAREAQNNNTNSDThpFSTpLHKRSNR+LDRRCEYIFGhCSIKGNSAARRKKFLKTPLCQRYLNN................................	2	0	0	0
+6930	PF07102	DUF1364		Protein of unknown function (DUF1364)	Moxon SJ	anon	Pfam-B_14821 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 95 residues in length. The function of this family is unknown. 	29.50	29.50	29.50	29.50	29.10	29.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.38	0.72	-4.11	13	531	2009-01-15 18:05:59	2003-08-27 09:33:10	7	4	387	1	29	247	9	91.50	59	93.90	CHANGED	pscLRcAARGcpCplRIPGlCNtNPETTVLAH...hRhsuhpGsGhKscDhhusaACSuCHDtIDuRs+t...hspEphchhthcGlhRTtthLhccGhl	........................MusLRKtARGRECQVRIsGl.....CNG...NP..EToVL.AH.......hRhAG.hCGT..G..hKPsDLluAhACSuCHDEIDRRT+h.......lDs..c-s+hhtlEGlhRTQsIhlKEGhl............................	0	3	9	19
+6931	PF07103	DUF1365		Protein of unknown function (DUF1365)	Moxon SJ	anon	Pfam-B_14846 (release 10.0)	Family	This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.	25.00	25.00	26.80	26.50	24.50	24.10	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.76	0.70	-5.33	104	812	2009-01-15 18:05:59	2003-08-27 09:37:11	6	11	766	0	319	782	1520	234.30	30	80.99	CHANGED	uslahGpVhHpRhpPhpHpFpYplhhhhlDLD..-ls.................th...phst.hauhs+h.shhuF+cpDa.........................ushpts......ltshlpph...tGhp.s..GclhLLspsRhhGasFNPlShYaCacpssp.....L.psllAEVsNT.as-RHsYllsh...............tstphpscKsFHVSPFhshchpYca+hs.s......sc.cltl.....plp.p......................pt.................hhsAolshpRpP......LosssLhcshlphPhhol+llsuIaWQAL+L.alKtlPhhs.+Pss.pp	......................................................................tlh.GplhHpRh....t..P...h..p..HpFpY..phhhhhlDLD........cls...............................................................pl......th.h..hhu.....p....t..h...sh...hp..FcppD.ah..................................................................s.sh.pts.....ltsp.lpph...........pGhp.s...GclhhLspsRhh.Ga.h.FNPlohaasa........cp.ssp.....................L.phllAEVsNT.asERHsYllss.................................tthphphsK.sFHVSPF.sh.p.t.pYp...a+hp.s................sc..pltl.........plphp....................................pt..................tthhsAols.....hp.tps........lo.s.t....s...l.....hp.....hhhphPhhs.h+lhh.....tIaWpA..l+L.ah.K..t.s.Phhs+Pt...p...............................................................	0	91	197	265
+6932	PF07104	DUF1366		Protein of unknown function (DUF1366)	Moxon SJ, Sammut SJ	anon	Pfam-B_14849 (release 10.0)	Family	This family consists of several hypothetical Streptococcus thermophilus bacteriophage proteins of around 130 residues in length. One of the sequences in this family, from phage Sfi11 (Swiss:O80186) is known as Gp149. The function of this family is unknown. 	21.60	21.60	21.60	22.00	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.45	0.71	-4.47	7	78	2009-01-15 18:05:59	2003-08-27 09:44:18	6	1	46	0	9	64	0	113.10	35	67.89	CHANGED	M.hEatup..ph.sstustusKVlLcspD...Gu.lPlhLPsEhhDhopsElLpps.clIYQc.aPp+AEsEKFs-Ls.......t..th.ptp.sKhEphhphuosTL.slIsphhtccshsD-sl	..............h...plsuKYPphDuoGulsuT+VIlss-D...GuhIs.h..l.pDhhspssoEllctsLEpahcppas-hAhuEthpKlD..............-..cKh.pppssK...stcs...spsA......................shh.............................	0	0	6	8
+6933	PF07105	DUF1367		Protein of unknown function (DUF1367)	Moxon SJ	anon	Pfam-B_14892 (release 10.0)	Family	This family consists of several highly conserved, hypothetical phage proteins of around 200 residues in length. The function of this family is unknown. Some proteins are annotated as IrsA (intracellular response to stress).	25.00	25.00	27.30	25.20	18.40	24.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.24	0.71	-4.90	9	383	2009-01-15 18:05:59	2003-08-27 09:48:02	6	3	265	0	27	249	3	156.50	44	98.30	CHANGED	MA.phphIKpusGhLlPATP-sp-hLp.+hKhGsVlhu-F....KpVRNPtFHRKFFALLsLGFEYWEPsGGslospEpcLlpGaspaLstasGpc..ssLt-hAspYLtplutcR.ssslulpKSF-AFRcWVTVEAGaYclhphPDGolt+cP+SISFAuMD-hEFppLY+usLsVLWpaIL..sRpFsopp-sEsAAsQLhsFs	...................MA.c.lphlKp.usGlLlPATscst-h.......Lp.plKlGt.hlh.A-.F....+ps..RN...AFH++FF.t.LLpLGF-YWpPsGGslostEpcLlpGaspaLst...sGpc....ssL.....psA-pYLpplAppR..st..s..h..ulhKSF-AaRtWVTlpAGaYs.th.hP.DGoht++s+SIuFusMD.-sEFpplYKusLsVLWpaIL...RpFpo.ppsENsAuQLhpFA..............................	0	0	7	17
+6934	PF07106	TBPIP		Tat binding protein 1(TBP-1)-interacting protein (TBPIP)	Moxon SJ	anon	Pfam-B_14830 (release 10.0)	Family	This family consists of several eukaryotic TBP-1 interacting protein (TBPIP) sequences. TBP-1 has been demonstrated to interact with the human immunodeficiency virus type 1 (HIV-1) viral protein Tat, then modulate the essential replication process of HIV. In addition, TBP-1 has been shown to be a component of the 26S proteasome, a basic multiprotein complex that degrades ubiquitinated proteins in an ATP-dependent fashion. Human TBPIP interacts with human TBP-1 then modulates the inhibitory action of human TBP-1 on HIV-Tat-mediated transactivation [1].	30.00	30.00	30.20	30.00	29.90	29.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.19	0.71	-4.71	12	266	2012-10-04 14:01:12	2003-08-27 11:17:55	8	8	222	0	184	281	2	151.20	26	63.87	CHANGED	-ApshlhcYlpcpNRPaSsp-lhsNLpp..tluKssVpKsL-pLspps+IhpK.YGKt.KIYhssQpphc.ssst-lpclchc.lppLppclptlppphpplppcl+pLppsLsst-lhcplppl+cclpphcc+Lcslcp.shp...lo.--hpplhpppphhpptapKRK+hhp	...............................thlhpahpppNRPasspslhsNLpp...tlsK.stl...KsL-pLspp......sclhtK...h.....GKp..+lY..hspQs........ph.p............ss........st-.lpthctp....lt....pLppplpplppphpphc.scLppLpuphost-.hppplppLcp.-....hpphpp+Lpplc......s...sssh........ls.s..--tp......pl....cphpphpppapcRK+hh............................................	0	74	108	153
+6935	PF07107	WI12		Wound-induced protein WI12	Moxon SJ	anon	Pfam-B_15477 (release 10.0)	Domain	This family consists of several plant wound-induced protein sequences related to WI12 from Mesembryanthemum crystallinum (Swiss:Q9XES3). Wounding, methyl jasmonate, and pathogen infection is known to induce local WI12 expression. WI12 expression is also thought to be developmentally controlled in the placenta and developing seeds. WI12 preferentially accumulates in the cell wall and it has been suggested that it plays a role in the reinforcement of cell wall composition after wounding and during plant development [1]. This family seems partly related to the NTF2-like superfamily.	21.50	21.50	21.50	22.30	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.66	0.72	-4.17	7	77	2012-10-03 02:27:23	2003-08-27 11:26:04	6	4	22	0	43	83	0	103.80	44	66.72	CHANGED	MRLLTG.us.usuSFpFpPpSVsuF...GssVlAEG.sDsspplhWVHAWTVs...sG..lITplREYhNTsLTVTRlu.sssuptst...................pspslWpSphssRAtKslPuLlLAl	....................................M+lLTG...ts.........p.....p..s.......u..........FpF.Ppulsuh.......Gs.sVlAEG......t.p..stp.........h...YWVHAWTVs...sG..lITQlREYFNTsLTVTcls..s.t.......................................ttstslWpSph.....s..-.ht+SlPGLVLAI........................	1	5	30	38
+6936	PF07108	PipA		PipA protein	Moxon SJ	anon	Pfam-B_15507 (release 10.0)	Family	This family consists of several Salmonella PipA (pathogenicity island-encoded protein A) and related phage sequences. PipA is thought to contribute to enteric but not to systemic salmonellosis [1]. The family carries a highly conserved HEXXH sequence motif along with several highly conserved glutamic acid residues which might be indicative of the family being a metallo-peptidase.	25.00	25.00	28.80	109.90	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.27	0.71	-4.94	4	164	2009-01-15 18:05:59	2003-08-27 11:31:57	6	1	116	0	4	64	0	174.20	86	93.04	CHANGED	sssFPDlPEHussPS.lRLuaDplATNS-h+LcP.EplsEYhISGsGGIDPDhEIDDDhYsECapcLSpILpsAYTQStTFRRLMNYAYDpELaDlEpRWLLGAGEsFuTTVTsE-LpsSpGRKVIsLNLD-ssD.sshPEpYESs-GP.p.FDTpRSFhHEIVHALTpLpDcE-NHPRGPVVEYTNIILKEMGppSPPRItY	........................................phVEYLISGAGGIDPDTEIDDDTYDECYDELSSVLQNAYTQSETFRRLMNYAYEKELHDVEQRWLLGAGEAFETTVAQEHFKLSEGRKVICLNLDDSD..DSYTEHYESNEG..QLFDTKRSFIHEVVHALTHLQDKEENHPRGPVVEYTNIILKEMGHPSPPRMsY..	0	0	0	3
+6937	PF07109	Mg-por_mtran_C		Magnesium-protoporphyrin IX methyltransferase C-terminus	Vella Briffa B	anon	Pfam-B_12015 (release 10.0)	Family	This family represents the C-terminus (approximately 100 residues) of bacterial and eukaryotic Magnesium-protoporphyrin IX methyltransferase (EC:2.1.1.11). This converts magnesium-protoporphyrin IX to magnesium-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor [1].	19.70	19.70	23.30	22.40	17.40	15.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.11	0.72	-3.94	15	218	2012-10-10 17:06:42	2003-08-27 11:38:22	6	12	204	0	98	221	233	97.50	38	40.22	CHANGED	shDsLIHYsspDssthLu+LuShspppllhoFAP+TshLshh+pIGcLFPtusRosthh.Hu.pslp+tlss....tGapls+pthlostFYhSphLEhs.	..ChDVLIHYPppcssphls+LuuhscppllhoFAP+TshLslh+tlGclFPtss+s..Tphh.hpEpsltctl..tp.....sG..a..pltRpphssssFYhSpllEhh..................	0	26	59	80
+6938	PF07110	EthD		EthD domain	Moxon SJ, Bateman A	anon	Pfam-B_15539 (release 10.0)	Domain	This family consists of several bacterial sequences which are related to the EthD protein of Rhodococcus ruber (Swiss:Q93EX2). In Rhodococcus ruber, EthD is thought to be involved in the degradation of ethyl tert-butyl ether (ETBE). EthD synthesis is induced by ETBE but it's exact function is unknown, it is however thought to be essential to the ETBE degradation system.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.11	0.72	-3.05	57	827	2012-10-02 00:20:33	2003-08-27 11:42:09	6	16	516	4	432	846	223	86.60	19	56.80	CHANGED	suho.ccFpcaapphHuslstplhs.......h.ta....................h..ttthhhhtsstsshsaDuhsphha...p..shcshhshhpsPthtt....ltsDc.tpFsDts	.............................................hs.ttat.caapppHs.s.l.stph.u.................................................h.hhttths.t.s..hsss...sssa....cuhschhF......c...shcsh.t...s....u...hs...ss...phpt...........hhsD...pFh...t.........................	0	94	256	355
+6939	PF07111	HCR		Alpha helical coiled-coil rod protein (HCR)	Moxon SJ	anon	Pfam-B_15548 (release 10.0)	Family	This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation [1].	20.70	20.70	20.80	20.80	19.40	20.60	hmmbuild  -o /dev/null HMM SEED	739	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.47	0.70	-13.35	0.70	-6.53	3	174	2009-01-15 18:05:59	2003-08-27 11:50:30	7	5	41	0	36	159	0	342.80	49	90.71	CHANGED	MAPTWASDlPLVQuPupQDVLERRLDsQRspVTMWGpDsu.uDuQ-PGRRGRSh-LEtSQALSQQAELISRQLQELRRLEEEVR.LRETSLQQKMRLEAQAhELEALAhAEKAGRAEAEGLRAALAGAEhVRKNLEEGuQ+ELEElQRLHQEQLSSLTQAHpEALSSLsSKAEGLEKSLsSLETRRAGEAKpLAtAQ+EADhLRcQLSKTQEELEAQVTLVEsLRKYVGEQVluEs+SQsWELERpELL-TlKHLQEDRAuLQATVELLQVRVQSLTHILALQEEELTRKlQPlDsLEPEFsRKCRSLLsRWREKVFALMVQLKAQELpHuDSTsQL+tQVAELQEcVTSQSQEQAILQRSLQDKsAEVEVERMuoKuLQhELSRAQEARRRhQQQlASAEEQL+LVVsAVsSSQttLpoTMA+VEpAlAQLPSLSNRLSYAVRKVHTI+GLlARKVALAQLRQESSPP...APu.ssDLSlELcQLREERNRLDAELQLSARLIQQEVGRAREQGEsERQRLuEVAQQLERELQcoQESLASlGtQLEAARpGQQESTEEAASLRQELTQQQElYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR+AAQEKERNQELRRLQEEARKEEGQRLoRRLQELERDKNLML..............QRLLsVLPSulsKK....sSPRPlEsSuStSlPAAsPsRESlKGSLTVLLDsLQGLSEAIS+-EslC.tDN.cs+oSsNPPsoP	.......................................................................................oht...htsSpu...LSQQAElIsRQLQElp.LEtEl...LREsS.lp.Qph+LEsQA.....EL-..tLt...t-p...sup....sE..sEtL+ttlutut..+.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	9	14	20
+6940	PF07112	DUF1368		Protein of unknown function (DUF1368)	Moxon SJ	anon	Pfam-B_14994 (release 10.0)	Family	This family consists of several proteins with seem to be specific to red algae plasmids. Members of this family are typically around 415 residues in length. The function of this family is unknown.	25.00	25.00	33.20	33.00	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.40	0.70	-5.87	5	9	2009-01-15 18:05:59	2003-08-27 11:53:47	6	1	4	0	0	10	0	326.00	37	95.41	CHANGED	EVcR..IoclllcS.chSKQYFLYKScslV.SsSsSEDDWpYCLLILKFlsPpsslKsIopILEaFL+cDRYRDKFsccauYLsTTIpKVIlpSSppNLlGssYspso...+-lIQ.sulDShaspss.I+sS.CosssVLKIsNFhShFaLcpsKYSsplhDaclshososNsolKISMhGGLLNYFDLMlFLuILYsY....KlsopLssssI.......lcINFSs.l-hMLpsNGo.sR+KYlNSLcKLSKVHL-s..p.h.shlsshpsspcphhsFSGsLLoFEpLSssp.Tpssl.hLSpPll..+hhcS.ssYSlVNWsSFlsLssoplRLlYFYFCLNVKsSpY.FTpFolcpLlccLYsusshuSohRhh+SclRKhLhhlh-sppshlDF-FpLVhs.spSpplISuIKVRRs+lhl.R	.................clhp..I.p.l.pS.p..+pYhlYh.pshh.p.SsSEDDWpaClLlLpalpP.sshchhsplLchFL+pDRaRsKhppp.sYLppTItKsI..u.p.pllGs.h..p....tp.lQ..ulsp.hsp.s.lp.S.sphpsVLKl.NhhShhaLppsphSs.h.chthshs.spssslKlS..hGlLNaFDLhlFluILYta........K..s.h..ssl.......lsINhSs...hshhhpssGp..RtKalNSL.KLS+Vplcs.......h.shh.tsptphhphoupLLsFptlphpp.T.hpl.hLSpPll..+hhp.hsNYSlVNWtSFs.LsssplRLlYFYFCLpVKsSpY.FTpF.lcpllpcLYhusshpoohR.hp.phRp.L..h.p....h.-hphpl.hp..pp..hIp.IKVRR.phh..h..	1	0	0	0
+6942	PF07114	DUF1370		Protein of unknown function (DUF1370)	Moxon SJ	anon	Pfam-B_15274 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 200 residues in length. Members of this family seem to be specific to mammals and their function is unknown.	25.00	25.00	25.50	25.30	24.00	23.60	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.14	0.71	-5.08	6	118	2009-01-15 18:05:59	2003-08-27 12:38:11	6	1	72	0	70	120	0	175.20	33	88.12	CHANGED	su+h+cshIIEhIs+KFcpLPEs-RsLhpaGolYlGhNAuhuGllANSLFRRlL+VoputlsouLPMAsLPFLTTsloYpshVosPL.oGDLsCETCslhRuuLlGlVsGGlYPlhLAlPVNGGLAARYposPLPpKGNIlpaWhslSpPVhKKMuFPLlLQshFGsalGS+HYplh.KsLphs.P-	..........................................hh.hlt+php.L.ct.-..pph..aGsshlGssAuhsGlhuNslFR+tLpV.p.p.u.tlpohLPh.uslPFLoTs...lsY+hhVsp.P.Lho...usl.s.CtsChhhRuuLlGllhGslYPshLAhshNutLAs...+..Ypos......LP....pK...G.....p....ll....haWhplspPlh+tMhhsllhQshFuhalu.....ppatlh.chhph......................................................	0	10	14	35
+6943	PF07115	DUF1371		Protein of unknown function (DUF1371)	Moxon SJ	anon	Pfam-B_15275 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 110 residues in length. The function of this family is unknown but members seem to be specific to Borrelia burgdorferi (Lyme disease spirochete).	24.90	24.90	25.10	25.00	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.51	0.72	-3.90	3	117	2009-01-15 18:05:59	2003-08-27 12:40:45	6	1	31	0	10	64	2	106.60	68	99.47	CHANGED	MDLRIGNNFELVFNNDFSLVDGIEEQKQRLFIFLKTLRGSLSYAPNWGLDYhLLLKLLKINNL-AVKNYFaEISKELNLDLINlSsoIQD+KlHISFFFsG.DVLNMEFcL	...........MDLRlGNNFELV.FNNDLSL.VDGI-EQKQRhhIFLKTLRGSLSYAPpWGLDYhLLLKLLKINNLcAVKNYFaE.ISKEL.N.LDLINISsoIQD...pKspISFFFoG.DlLNMEFsL.............	0	6	6	6
+6944	PF07116	DUF1372		Protein of unknown function (DUF1372)	Moxon SJ	anon	Pfam-B_15278 (release 10.0)	Family	This family consists of several Streptococcus bacteriophage sequences and related proteins from Streptococcus species. Members of this family are typically around 100 residues in length and their function is unknown.	25.00	25.00	36.00	35.80	18.50	17.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.53	0.72	-4.07	7	50	2009-01-15 18:05:59	2003-08-27 12:44:28	6	1	46	0	3	42	0	88.30	43	95.42	CHANGED	Mp........c....s.htlAshlllluhlhshshlhhhhs...s.+.spsllIapVDNuss.MaGKlTsKphltthYTlsstAYGKFLVTKEQYcsIpVGDDIPsYLKG	..........................................hh...................hhshhllluhshshhthhhhht.......c..phcsllIYKsDNsGuElaGKVs-KphlGcLYTlThpsYGhFlVTKEQY-plcVGD-l........	0	0	0	0
+6945	PF07117	DUF1373		Protein of unknown function (DUF1373)	Moxon SJ	anon	Pfam-B_15084 (release 10.0)	Family	This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.	25.00	25.00	25.30	28.00	22.50	24.00	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.64	0.70	-4.60	3	35	2009-01-15 18:05:59	2003-08-27 12:58:46	6	1	1	0	19	10	0	190.70	68	97.25	CHANGED	M.RVLWIsCLLIGSIoCLPQGGss..ssu....hPPYoGQ..ScPSYE+PSGQ.SGYSosPGYYSuGTpTuGGS..GSPPMWYSASYPEQEPAKPTYQRPAQSSGYGSYGuVDSSYSGSGSQQSGSQGAQSGAPGSQHQVEQESWSSSSDDEDEPEFTPVSEEDQVYASKTRSRYNQKRLLFSQFRYTPTEPRVPQEPVFPYPSKSHQGKGSAKGSR	......................RhLWlSCLLIGoIoChP.QtGhs...s...........hh....YoGQ...tPSYE+PStQuS...G...YSS..GhYSuuT...NTAGuS..uosPMWYSASYPEQEPAKPTYQRPA.QSSGYGS.ss...stt.SYSGSGSQQSGSQGuQSGsPGSQHQVEQESWSSSS..D..DEEEPEFTPVSEEDQVYA.KSRSRYNQKRLLFSQFRYTPTEP.RVPQEPVFPYPSK.SHQGKGSAKGSR.....	0	0	0	19
+6946	PF07118	DUF1374		Protein of unknown function (DUF1374)	Moxon SJ	anon	Pfam-B_15191 (release 10.0)	Family	This family consists of several hypothetical Sulfolobus virus proteins of around 100 residues in length. The function of this family is unknown.	20.70	20.70	21.40	21.30	20.00	19.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.94	0.72	-3.88	15	27	2009-09-11 20:35:31	2003-08-27 13:01:18	6	1	6	7	0	32	0	87.10	29	91.45	CHANGED	cFc-LK.sllchFFc-pplpElsLcFpcpl.lTEpEacELIpsschhpphpsp....sIhsDhYpYhEspNphhKL.IcYa+cs-.KIhIhEIchWR-	.....hcplc.pllphFFcspplpEhslpFcp.lclsEp-acpLlt..s.hpthtst......tlhh-.a.Yhp.ssthlKl.lpYh+css.KIhlhEIphaRc.	0	0	0	0
+6947	PF07119	DUF1375		Protein of unknown function (DUF1375)	Moxon SJ	anon	Pfam-B_15247 (release 10.0)	Family	This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the Class Gammaproteobacteria. The function of this family is unknown.	20.30	20.30	22.60	22.30	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.65	0.72	-4.15	41	1264	2009-01-15 18:05:59	2003-08-27 13:05:19	7	3	710	0	129	455	12	66.60	48	72.28	CHANGED	L..lssh....hLsGCuolhohs.ssppsh................hYsGsphshphhpt.................shhhhslshlDLPhShllDTLLLPashh	..................................................h.h.....h...hLuGCuSlhS+ThstpGp.....................YPGsphssp.hu.....................................+.lsILDlPFShVhDTLLLPhDl.a....	0	10	27	78
+6948	PF07120	DUF1376		Protein of unknown function (DUF1376)	Moxon SJ	anon	Pfam-B_15380 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.	21.20	21.20	21.30	21.20	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.77	0.72	-3.85	24	221	2009-01-15 18:05:59	2003-08-27 13:08:51	6	4	156	0	60	198	23	86.00	31	30.39	CHANGED	sa.aphaluDalp-..TtaLostEcGsYhhLLstha.....ps.ppsls.sDcthLsRlstspscc.tsshshllspF...ptpcspatpcRh-cEltph	.............sa.hphaIuDal.s-..Th+L.S..s.pE.+GsYhhL.hhpYa.....ps..scPlP..ppspLA+lsph..oscca...tsshs.lhc.F...htpsstahp.tRh-c-lst.h.........................................	0	9	29	42
+6950	PF07122	VLPT		Variable length PCR target protein (VLPT)	Moxon SJ	anon	Pfam-B_15500 (release 10.0)	Repeat	This family consists of a number of 29 residue repeats which seem to be specific to the Ehrlichia chaffeensis variable length PCR target (VLPT) protein. Ehrlichia chaffeensis is a tick-transmitted rickettsial agent and is responsible for human monocytic ehrlichiosis (HME). The function of this family is unknown [1]. 	20.20	20.20	23.80	24.30	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.11	0.72	-4.28	4	120	2009-01-15 18:05:59	2003-08-27 13:17:43	6	4	3	0	4	113	3	29.60	65	67.36	CHANGED	DLQQSSsSDLHts.pVEL.sPSKEtVQLEs	.....DLQQSSsSDLHtS.pVEL.sPSKEtVQLEs	0	4	4	4
+6951	PF07123	PsbW	PsbW_2; 	Photosystem II reaction centre W protein (PsbW)	Moxon SJ	anon	Pfam-B_15117 (release 10.0)	Family	This family consists of several plant specific photosystem II reaction centre W (PsbW) proteins. PsbW is a nuclear-encoded protein located in the thylakoid membrane of the chloroplast. PsbW is a core component of photosystem II but not photosystem I [1]. This family does not appear to be related to Pfam:PF03912.	25.40	25.40	26.20	29.20	22.70	25.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.90	0.71	-4.11	9	66	2009-09-11 00:41:56	2003-08-27 13:39:30	7	1	36	0	30	63	0	117.30	50	97.19	CHANGED	MsuluAsus....splsu+uhstssthhssh.s.sshslPuhps++...hhsshppc..hhpsh.....s.tsuhhussuu.hs....utPAhALVD-Rhss-GTGLPLGlssshLGaILhGVFshIWuLYhlhs+s....lp..cD-DS.GLuL	...............................................................shGLPthtttt..tlpCshppc.t..t......huh....uuuhhAAsuuhhs....usP.AhALVDERhSTEGTGLsLGLSNNLLGWILlGVFGLIWuLYhlYoSs....L-....ED--S.GLSL...........	0	7	21	28
+6952	PF07124	Phytoreo_P8		Phytoreovirus outer capsid protein P8	Moxon SJ	anon	Pfam-B_15606 (release 10.0)	Family	This family consists of several Phytoreovirus outer capsid protein P8 sequences [1].	21.20	21.20	556.10	556.00	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.40	0.70	-5.82	4	19	2009-01-15 18:05:59	2003-08-27 13:57:44	6	1	8	13	0	19	0	423.20	64	100.00	CHANGED	MSRQsWlETSALlEsISEYlV+s.GDTFpGLThsDloTLSNLhsQLSlusVGFLND.RTPLQsMSNpFVsFISTTDRCuaMLp.sWFDSDltPsV.TDNFIssYIKsRhSsPlSDslRQlNNLSLpPpts.KlhSpQNAlhKALD.PYuoPl-PpcLhRuoAst.sGNhspRRuLsTsLstGAps.sFhVuE+c+IlFGpRS.NslsAupYpINVPsaaSsLsVTsARlYFTNSFlGsTIsNVpVNA.NGsssVAsIpVPTDsNshsVDSDulVSFSLuGGsINVsTuVshTGFAIAIEG-FphQMNRsQSYYThsSITh.sslsIDDFGlosaLEsFR.RLhACGQsEIFS-uMNpLT.sLIsNYhssstssshlAFsSPWYRhSERhtTILoF.ptslsLppR+LhVRHLWVIhSFIAVFGRYYssN	MSRQAWl-TSALlEsISEYss+CoaDTFpGLThsDhssLSNLhsQlSVuSVGalsDPRsPLQsMSspFVsFISTsDRpuYMLpKsWFsSDltPsV.oDsFIATYIKPRhphshSDVLRQlNNhALQP.tsPKLIsRQ.uVhKuhDIPYSTPIpPpDlhRSsAss.sGNVuphthLuTP.l..AQNsTFhVuEpc+IlFGhRShssIssGNaQIsVPPWhSsLsVssARlYFTNSFhGsTItsVpssAVsGsDsssTlTVPTDsNshlVsSDSVVSLSLuGGsINVThuVshTGasIAIEGcFsM.hNtS.uYYTLoSlTh.sss.IDDFGLSAFLpPFhhpLRAsGQsEIFSpuMNsLTpsLIppYMsAstAss.IAFsSPWaRFSERARTILsh.tsllshssRKLIIRHLWVIhShIAVFGRYYpsN.	1	0	0	0
+6953	PF07125	DUF1378		Protein of unknown function (DUF1378)	Moxon SJ	anon	Pfam-B_15650 (release 10.0)	Family	This family consists of hypothetical bacterial and phage proteins of around 59 residues in length. Bacterial members of this family seem to be specific to Enterobacteria. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	25.90	44.70	21.50	17.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.86	0.72	-4.02	3	166	2009-01-15 18:05:59	2003-08-27 14:01:00	6	1	103	0	3	53	0	58.30	75	98.88	CHANGED	MTFVpplLLYFCTVVCsLYLVSGGYKVIRNYIRRKIDcAAAEKISASQSAGSKPEEPLI	.MTFlpplhLYFCTVVCsLYLlSGGY+AhRDaWRRQIDKRAAEKI.SASQSAGSKPEEPLI..................................	0	0	0	3
+6954	PF07126	DUF1379		Protein of unknown function (DUF1379)	Moxon SJ	anon	Pfam-B_15837 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	25.00	25.00	31.00	30.90	18.70	18.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.63	0.71	-4.84	33	709	2009-01-15 18:05:59	2003-08-27 14:03:06	7	1	704	0	77	265	9	154.00	63	85.88	CHANGED	hLcLuscMlFposaptKhLlssAhspstFsV-DAuhYhpahEpl.sp.lslocsppsplsLNAsAApRFhKPhMPKSWaFpsp..stsh.PppGclhp..LpsstppuphlVlEsu-pAoLChLls.pphtLsssKslt.h-sIKVMpDRltPhpst...hph	.....MLDLANGMLFRSRFuRKMLTPDA..FsPsGFCVDDAALYFSFEEKC.RD.hsLSKEQ+A.ELVLNALVAIRaLKPQMPKSWHFVuH...GchWsPhsGDAAsVaLSDTtEQVNLLVVEs..GENAALCLLAQ.PsVVlAG.RsMQLGDAIKIMNDRLKPQls.....hssh..	0	6	22	48
+6955	PF07127	Nodulin_late		Late nodulin protein	Moxon SJ	anon	Pfam-B_15657 (release 10.0)	Family	This family consists of several plant specific late nodulin sequences which are homologous to the Pisum sativum (Garden pea) ENOD3 protein.  ENOD3 is expressed in the late stages of root nodule formation and contains two pairs of cysteine residues towards the C-terminus which may be involved in metal-binding [1].	29.90	29.90	30.10	30.00	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.15	0.72	-3.84	92	434	2009-01-15 18:05:59	2003-08-27 14:53:18	6	9	8	0	2	491	0	55.00	33	72.20	CHANGED	MucllK..FVYsh....IlFlSLFLl.stsss.........hhtCpsDsDCPph.......hs.hhh+Cl.sthCp	...............MscllK..F.VYsh....Il..FlSL.FL.l.sp.ssp.................hhtCpsDs.DCPph.........h.hs..hhh+Cl.p.thC.....................	0	1	1	1
+6956	PF07128	DUF1380		Protein of unknown function (DUF1380)	Moxon SJ	anon	Pfam-B_15699 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 140 residues in length. Members of this family seem to be specific to Enterobacteria. The function of this family is unknown.	21.40	21.40	21.70	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.76	0.71	-4.36	3	549	2009-09-11 02:05:09	2003-08-27 14:58:00	7	2	244	0	12	281	0	130.40	49	93.64	CHANGED	MYGTCETLCRhLsEQYPAETPLNLIIWSPADIEALADGMEYSlSEHDlRAVLARMDsIPEEQRLESGVSAGAVM-LI-QVKENsptVTVPADLLETLLpTAEQALW+REWTARD+NLPVPESVTRRLADsAKVRALLKs	..........MYsTscplhR.t.LsschPsspslhhVlho.t-lptl.Ap...DhSLoDcElcTVhtRL-Dh.E...ctts-suI.sp...ssVh.Elhpp.hp...c.s.......RQVTVPA.hLtplhthAtp.h...........................................................................	0	1	3	9
+6957	PF07129	DUF1381		Protein of unknown function (DUF1381)	Moxon SJ	anon	Pfam-B_15743 (release 10.0)	Family	This family consists of several hypothetical Staphylococcus aureus and Staphylococcus aureus bacteriophage proteins of around 65 residues in length. The function of this family is unknown.	25.00	25.00	34.70	42.70	24.90	19.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.95	0.72	-4.56	6	367	2009-01-15 18:05:59	2003-08-27 15:00:33	6	2	205	0	9	129	0	43.80	83	63.12	CHANGED	pQYLITpFpDSTGpsHscls+AR-NpohTlVEAESKEEAlcKYc	.TQYLVTTFKDSTGRpHTHIT+AKsNQpFTVVEAESKEEAKEKYE.....	0	3	3	9
+6958	PF07130	YebG		YebG protein	Moxon SJ	anon	Pfam-B_15760 (release 10.0)	Family	This family consists of several bacterial YebG proteins of around 75 residues in length. The exact function of this protein is unknown but it is thought to be involved in the SOS response. The induction of the yebG gene occurs as cell enter into the stationary growth phase and is dependent on  is dependent on cyclic AMP and H-NS [1]. 	27.50	27.50	28.10	40.00	27.20	27.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.47	0.72	-4.29	32	761	2009-01-15 18:05:59	2003-08-27 15:05:55	7	1	755	5	92	274	16	74.10	64	75.84	CHANGED	MAVhspYVV.R-GhE.......KMTFsSKKEADAYDKMLDlADsLsshLppusltl-EsptEpLuhaLAppK-sltphLKus	.....MAVEVKYVV.l.R-GEE.......KMoFTSKKEADAYDKMLDhAD......lLssWLs..pSPl..th.--pQREuLSLaLAEpK-lLusILKs.u..........	0	16	31	64
+6959	PF07131	DUF1382		Protein of unknown function (DUF1382)	Moxon SJ, Eberhardt R	anon	Pfam-B_15770 (release 10.0)	Family	This family consists of several hypothetical Escherichia coli and bacteriophage lambda-like proteins of around 60 residues in length.  The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	34.00	33.80	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.82	0.72	-3.87	2	320	2009-01-15 18:05:59	2003-08-27 15:09:15	6	2	199	0	0	80	1	48.90	76	93.40	CHANGED	Mp+ASPs-LRpslEhAp.LAp.GlRFVPIPs.TDtEFtTLus.hupKlE.hAAcAEhpEpp	....................................PIPVETDEEFHTLAsSLSQKLEMMsAKAEA-ERD..........	0	0	0	0
+6961	PF07133	Merozoite_SPAM		Merozoite surface protein (SPAM)	Moxon SJ	anon	Pfam-B_15860 (release 10.0)	Family	This family consists of several Plasmodium falciparum SPAM (secreted polymorphic antigen associated with merozoites) proteins. Variation among SPAM alleles is the result of deletions and amino acid substitutions in non-repetitive sequences within and flanking the alanine heptad-repeat domain. Heptad repeats in which the a and d position contain hydrophobic residues generate amphipathic alpha-helices which give rise to helical bundles or coiled-coil structures in proteins. SPAM is an example of a P. falciparum antigen in which a repetitive sequence has features characteristic of a well-defined structural element [1,2]. 	24.30	24.30	24.30	24.30	24.20	23.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.24	0.71	-4.37	4	426	2009-09-10 23:03:07	2003-08-27 15:43:46	6	3	6	0	17	335	0	156.00	42	29.44	CHANGED	GWEFGGGs..sp.tssEcKKpc.lLEplploSWDKEsIsKENEDVh-EhpE-s---EEc.p.............EElEEsE-.-sEpEllE-c.pEEE...c-E-sscpc-.EKcspN-lss.........p.pD.pAQsLISpp.KcN-cs.KKoAEsllpsLhuLlpspNplDuTl+cLhpEhhcaFsNp	................................pKcc.hLEhlploScDcEsIsKcNED.V+EEhEEptE-p.EE.--p...................E.ElEpp...p-EE.T-E.EssEEcp.EEpE.....p...cc-.EE..sc.c....c..c.....p.p..EK.c..s.Ncpps................p.t....o.cpD.cAppLI.........Sps.KsNs-s.KcsAEoIVKoLhuLhpttst...s...................	0	6	6	15
+6962	PF07134	DUF1383		Protein of unknown function (DUF1383)	Moxon SJ	anon	Pfam-B_15868 (release 10.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 375 residues in length. The function of this family is unknown.	25.00	25.00	48.50	48.90	18.00	17.00	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.24	0.70	-5.52	18	40	2009-01-15 18:05:59	2003-08-27 15:58:01	6	1	36	0	0	42	0	313.60	31	85.79	CHANGED	-plhpQlap.tslPYIoKKtlNDpLpsplhtp............................sstpFaccsacsVhssh..sshhVlpGGAAhAsHlsst..psh...L...psLDh-hYht......................sshpp..alpLspLpccLp.ssspshhcslspllpslch..h..........................psslllhKsY.NtAlch.s....ssVphcLsc+...lKsshophN...--ahLVRFShNVcM..hS..tsu.lc.Yps.p.hlpphshhsFsVaFlslplh.....+pPh..s-......hphhslFsss.....VhVpslcpllsDQlpCLLaslF.s+sphKlcpRhspIpuLhsphspp.shssshpscc...hhtl.+ppspshohpplKclLhhhGPtLGs+tL	.......................................................................-plhppLa..tslPYIoKK.INDpLpcplltp............................sstpFa+cshcsshtsh......sshhVlpGGAAlAsHlspp.pst......LpslDh-hY..............................sshpp..hltLppLp.cpLp.pssppaasplcplhtslph.............................psplllhKsY.NtAhchs....splphcLNc+...lKsshoplN.......--ahLVRauhNVcM..pS....tsshh.aps.pshhpshshhsaslaFlslplh.....+pshshsc.....shphhslFGhs.....VhVpslcpllsDQlcCLLhslF.Np.paKlcpRls+lpsLhs.hsp..shso.shpppp...hhpl.+pps.pphohpplKplLhhhGPtLGs+tl.......	0	0	0	0
+6964	PF07136	DUF1385		Protein of unknown function (DUF1385)	Vella Briffa B	anon	Pfam-B_12671 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 300 residues in length. Some family members are predicted to be metal-dependent.	22.10	22.10	26.10	24.40	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.67	0.70	-5.29	57	654	2009-01-15 18:05:59	2003-08-28 10:03:17	6	3	631	0	173	542	224	241.30	41	75.66	CHANGED	lPhlRGhhsLh-ohslGh+sLsaSAshhtt-......t................................p-c..hsphthhhol....llShshulsLFhllPshlus...hh..p.h....h...sphh.hsllEGllRlslFl...sYlhhIShh.cDIcRVFpYHGAEHKsIpsYEsGt.LTVE...NVp+aSplHPRCGTSFLhhVhllSIll....Fshlsh...........tshhhRll..RllLlPlVuGloYEll+hsu+pps..ls+lluhP....GLhLQp.LTT+EPDDsQlEVAItulctsl.s.cp	.........................................................................lPFlRGlsull-uhshGhKpLsaSuphhtt-.....pp....................................................................c-c.hsph..thslsl.........llShlhuhslFhllPshluphh.....p.h........hs...sphhhsllEGll+lh.lhl...sY...Ih.hIShh..-I+RVFpYHGAEHKsIpsYE.sshtL.TVE...NVpK.oRLH.R...CGTS.Fl.lhlh..llulhl....a.h..l..lsh...............ssl...hhRllsRllLlPVVsGlSYEl.l+hsu+hcs..sll+lLuhP....GLhLQh.L.TT+EPcDcQlEVAIsuhctllt..p........	0	90	146	160
+6965	PF07137	VDE		Violaxanthin de-epoxidase (VDE)	Vella Briffa B	anon	Pfam-B_12679 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within plant violaxanthin de-epoxidase (VDE). In higher plants, violaxanthin de-epoxidase forms part of a conserved system that dissipates excess energy as heat in the light-harvesting complexes of photosystem II (PSII), thus protecting them from photo-inhibitory damage [1].	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.45	0.71	-4.47	7	98	2012-10-03 08:47:39	2003-08-29 13:30:32	6	4	50	4	43	95	4	180.50	60	51.01	CHANGED	EFNECAVSRKKCVPpKSDVGEFPVPDPSsLVpNFNMtDFsGKWaIoSGLNPTFDAFDCQLHEFHhEss.KLVGNLoWRI+TPDuGFFTRoAVQ+FVQDPsQPulLYNHDNEYLHYQDDWYILSSKIENKPDDYIFVYYRGRNDAWDGYGGAVlYTRSssLPESIlPELp+AApSVGRDFssFIRTDNTCGPEPPLVERl	.................................................EFN-CAVS+KKCV......PpKuDl..G-FPVPsPssLVcsFNhsDF..s..GKWYIoSGLNPTFDs.FDCQLHEF+.s.E.s.s...K..LluNLoWRI.c.....TP...D...uGFFTRoAlQ.+FVQ..DP.s.pPuI.......LY........NH..DNE..a...LHYQDDWY....IlS.SKl....-Nc.DD...YlFVYYRG+N.DAWDGYGGAVlYTRStsl.PcSIlPELc+AAKpVGhDFsp.FlcTDN...TCGPEPsLhtRl............................	0	20	35	40
+6966	PF07138	DUF1386		Protein of unknown function (DUF1386)	Moxon SJ	anon	Pfam-B_16196 (release 10.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 350 residues in length. The function of this family is unknown.	21.40	21.40	23.00	95.40	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.09	0.70	-5.31	8	20	2009-01-15 18:05:59	2003-08-29 13:55:16	6	1	18	0	0	19	0	319.90	47	97.50	CHANGED	MSLSSKLLVYAYYG.sYNhsHc+YGESYHLYRIVcE+Los.....oYVsssSCVRRDIsTARpL..ssGtlsF--ARphLDls-sAspLosWYpsG-.ooGlCu-VQpVLspIDpasPL-+RVppGu.........sIauLDs.hs-Isp-hsssLQslIGR.FhHFsRsssLsHVA-VFDPs..l+ssGWWYpKFCVLTYMHRlhssuVPsELhsRLpcAVsKaI+Ps...........DcuNCA.AlAsVYGRFCGIGR-HFu+HKsssh+ILFQYMRuchT.ssERassFuVIKDFGRpCKETYpDL+spADsLYIpuoTD+pKNALFDLLCCsNAs-IDsDCYDYIV...spFYs	...........................................................MSLuuKLlVYsYYu.pYNtsHchYGESYHLYRIVpEaLoc.....SYVsshSClcRDlssARRL..psGshsFD-AhphlDss-oscpLSpWasT.G-..opGlsssVppVLppIDshsPlshRVppG.t.........pIFuL-s.........pEIsp-h....sDsLQhllGR.FhaFhRsspLh+lAsVFsPs..tcs...sGWWYsKFCVlTYhHRIhtpuVP...sELh.sRLpcAVpKaI+.p..........t-phNCscslA-lYGRFCGIG+EHFu+HKhsCh+ILFQYlR.GcsT.p--cFsCapVIKDFGRpCK-sYcsL+shhDhLahauhoDKcKNuLFDLLCshsspEIDlDCa.YIh...cpFh....	0	0	0	0
+6967	PF07139	DUF1387		Protein of unknown function (DUF1387)	Vella Briffa B	anon	Pfam-B_10471 (release 10.0)	Family	This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.	25.00	25.00	25.60	25.20	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.10	0.70	-4.81	6	164	2009-01-15 18:05:59	2003-08-29 15:07:34	6	4	51	0	64	117	0	236.20	51	55.81	CHANGED	WoVTGKK.KNtKKKKsKsKscusspsA....t+..shs.ppssPss-.cs.sNGaHsNGuth.DoESlDSLSEtL-ohSLDA+E...scssh.-hsspsssshpsG.sch.ppK..hpssPcuopss.......p.stt..sp.pp..t.ss.hhpp............hu+KhusNIE+SVKDLQRCTsSLuRYRVllKEEMDSSIKKhKQTFAELpSCLMDREVALLAEMDKVKuEAM-IL-sRQK+AEELK+LTDhAupMoEEQLsELRADIKHFVSERKYDE-LG+AsRFosDlEsLKpSIpoaGpVsHPKssYSsRot.CS	....................................................................................................................WshTGKK.KN.K+K+sKsK.tttspsu....p+..sh..p.tss..p......NG....+hNGs.p.DopSsD..ShsEt....ul.sRE......c...uh...-....spsh...p.hlppu...t.h....p.+..h......tt....ps.pt...............p.s..tt.t.s.p..s.....thss.h.ps..........................................thsKKh....G.sNIEKSVKDLQRCTVSLsRYRVhlKEEhDuSlKKhKtuFAELpsClhD+EVuLhAEMDKVKtEAMEILhuRQKKAE.LK+hTDlAspMuE.QLsELRA-IKHFVSERKYDE-LG+sARFoCDlEpLKtpI..hGpl..oHPKNsYSsRo..C..................................................	0	9	14	26
+6968	PF07140	IFNGR1		Interferon gamma receptor (IFNGR1)	Moxon SJ	anon	Pfam-B_15930 (release 10.0)	Family	This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta).  The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection [2]. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac Pfam:PF01108.	20.70	20.70	25.70	24.80	19.30	18.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.26	0.71	-4.45	12	134	2012-10-03 16:25:20	2003-09-03 09:36:26	6	2	72	6	18	111	0	134.40	36	41.50	CHANGED	YsptshCshhhhYsshhpascopph...pYslc-p.CspstCplshsop...pplCVos.Gspps..h...pT-tSp-VCls.h.....................ssth.VsshhlKphsDlpphpptls+slpp+hcppop.t+..phY.shlsshhtthlp..............................-	.......................YccpshC.hhhlYss.hphscScEsh......pa.slc.-..DCspTtCplshsso...pchCVoApGsocsah....hT.hS.pEVCl...........................s.phsVhsCh..I+phpslpp.hp.ths+sl.hphhpp....top..........................tthh...........................................................	0	1	1	3
+6969	PF07141	Phage_term_sma		Putative bacteriophage terminase small subunit	Moxon SJ	anon	Pfam-B_15957 (release 10.0)	Family	This family consists of several putative Lactococcus bacteriophage terminase small subunit proteins. The exact function of this family is unknown.	22.80	22.80	23.10	28.50	19.60	22.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.07	0.71	-4.71	2	45	2009-01-15 18:05:59	2003-09-03 09:51:03	6	1	44	0	0	19	0	172.70	91	98.00	CHANGED	MQTQpGGRPTILPKMYEEPLFSQIIDKIESGCNDREIYTSLHCSAKTFRKWRDDNIKAYDEAKGIARGNLLELAESALASKLTVRTLKETETIYDADGNVEKVKVKEKELDKDSLVAMMVAKAGNPELYNPTEWRRLQQEESSAHDLKAKIEELDDYKLSKYcTPcIEVPcGFE	...MQTQNGGRPTILPKMYEEPLFSQIIDKIESGC.ND.REIYTSLHCSAKTFRKWRDDN...IKAYDEAKuIARGNLLELAESALASKLTVRTLKETETIYDAD.GN.....VEKVK.VKEKELDKDSLVAMMVAKAGNPELYNPTEWRRLQQEESSAHDLKAKIEELDDYKLSKYETPKIcsPEGFE................................................	0	0	0	0
+6970	PF07142	DUF1388		Repeat of unknown function (DUF1388)	Moxon SJ	anon	Pfam-B_16000 (release 10.0)	Repeat	This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo [1].	25.30	25.30	25.30	25.30	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.43	0.72	-4.23	28	466	2009-01-15 18:05:59	2003-09-03 10:27:34	7	28	45	0	52	575	2	29.10	50	24.82	CHANGED	PspsKoPuEsKoPs-sKoP..uEsKoPscpK	...............PscsKSPscsKSPscsKSP..scsKSPsctK......	0	5	5	7
+6971	PF07143	CrtC		Hydroxyneurosporene synthase (CrtC)	Moxon SJ	anon	Pfam-B_16004 (release 10.0)	Family	This family consists of several purple photosynthetic bacterial hydroxyneurosporene synthase (CrtC) proteins. The enzyme catalyses the conversion of various acyclic carotenes including 1-hydroxy derivatives. This broad substrate specificity reflects the participation of CrtC in 1'-HO-spheroidene and in spirilloxanthin biosynthesis [1].\	     This family also contains the members of the old Pfam family DUF2006.  Structural characterisation of DUF2006 family member Swiss:Q82US3 has revealed a lipocalin-like fold with domain duplication.	26.20	26.20	26.50	26.30	25.60	26.10	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.18	0.70	-5.13	69	733	2009-01-15 18:05:59	2003-09-03 10:38:50	6	6	601	2	267	685	396	285.70	23	77.79	CHANGED	hEWWYlsAphps....GpthssphshhtsshsP...................t.sstphhhspsAlh..........ssppphhhcchuRuu..lup........sssshpsh.......h-saphpups..................hslplstsutpht.........lclplpspss.hlh.sptGhoh+s.sts.....p.Auahau..tPhhplpGslsh.sut..php.........lp.......GpuWhD+pauo.......psLsps.suWDWhsh.....plss..Gps....LhhaplRppss.........................satsushhhss.Gps....h....s.ttlphps..hthsss.suhphPhtWplch.....ssps....lslphpslhpsu.h....ssshsYa......EGsltlptshs..........uhuahch.pGh	................................................................................................................................EWWYhsu.lp........stt....G.p.huhQhshhR.sht.....................................t.ssa.ts.plhh....uphul.s..........sttt...hhh..tp+huRsu.........hu.....Ash...........sspshphh.......lc...s.Wphputs.........................hshplph....ssp..shs...........................................lpLpl...ps...ptP....lhpGppG.hshKs..s.s........t.ASaaao........hPhhp.l...p...Gslsl..sup.......shp..........................Vp..................G.p.u.WhD+...EW.......uo..................phL..s...sst...p.GW.DWhsl.....pLss....Gpt......Lhha.p.lRppss.........................sh.htushh...ss..s....Gps......l.....tspplphps.........h.....phs..........s...........sst.p..hPh........t..Wplpl....sshs.........lslplpsl..tst.h........shth..sYW........EGs...lt.lp..G.sh.p..............uhGahch.oGY............................................................................................................	0	67	142	211
+6973	PF07145	PAM2	Ataxin-2; Ataxin-2_C;	Ataxin-2 C-terminal region	Albrecht M, Studholme DJ, Vella Briffa B	anon	[1]	Motif	The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for Pfam:PF00658. It has been found in a wide range of eukaryotic proteins [1]. Strikingly, this motif appears to occur solely outside of globular domains [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.47	0.73	-6.31	0.73	-4.08	53	834	2009-01-15 18:05:59	2003-09-03 11:18:39	10	35	156	12	410	759	0	17.60	49	3.57	CHANGED	stpSpLNPsApEFVPsst	.....hpSpLNPNApEFlPss....	0	62	129	229
+6974	PF07146	DUF1389		Protein of unknown function (DUF1389)	Moxon SJ	anon	Pfam-B_16027 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins which seem to be specific to Chlamydia pneumoniae. Members of this family are typically around 400 residues in length. The function of this family is unknown.	21.50	21.50	21.50	30.10	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.86	0.70	-5.37	15	75	2009-01-15 18:05:59	2003-09-03 11:21:53	6	2	13	0	20	46	1	296.70	27	70.81	CHANGED	shslslslSlllsuluhslhlhshhpthh.............ptpsIPpG...........................FpplI+cpYPcslaclVhpppLolpElRhllsuL...........ppshsphspcL+pKlcsF.Gl-pLpsshcstcL.............ssL-clLlcNCPLYWLp+F..IclGs+phs.........pssp........hpsssYWlu+lGh.......usstsTIFs.psalluplloc-EYphLhsHA+NsTWspsc..VpslppRl.hshlspthtttpcpspsplsp.....hhpcth.shLLtLCpHGlSW-QLQLlcplsscphsFLstl...-pup.hsstlpphshuhhs.t........alsEss.p.F-PsluLhTacEa+	........................lshhluhhhssluhslh.hshht.hh...............p.IPpu...........................applIpppaPpslhshlhpppLolpElRhllpsl.............psshsp....hsppL+p+lpsF.GlcplpsshpuhsL.............ssL-slLlppCPLYalp+F..IphGs+pl..........ptpt........hp.ssYWlschGh.......ssstsTIFp.hsalluphlSccEY.hLhp+Acss...s...Wsptp..VsulppRl..t.htphhh...ptcpshsphhs.......hhpc..tphLLhlCpHGlSWEQLQLl+pls.hcshtaLstl...-pus.hsttlpphhhshhs...........ahsppspp.a-spluLhTasEh........	0	0	0	18
+6975	PF07147	PDCD9		Mitochondrial 28S ribosomal protein S30 (PDCD9)	Moxon SJ	anon	Pfam-B_16045 (release 10.0)	Family	This family consists of several eukaryotic mitochondrial 28S ribosomal protein S30 (or programmed cell death protein 9 PDCD9) sequences. The exact function of this family is unknown although it is known to be a component of the mitochondrial ribosome and a component in cellular apoptotic signaling pathways [1].	25.00	25.00	28.20	25.70	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.37	0.70	-5.70	14	222	2009-01-15 18:05:59	2003-09-03 11:37:19	7	2	90	0	141	204	0	322.20	25	75.44	CHANGED	Mushpt...hp.l.............ttt....s.p.pp.ss.....sssshYPPIh.opshps+us+p+phcpa...................httlptssslcEKl.hhsthph................+ahsa......PpshshNu.caaQahTKTsh.suLP...s.t...............................................ptp..shschhhutlcshhpthhLQcpaappccc..........cppchsst.hLspLspslhshLupp.stLspsplDhsPplphaWsRGtph.s.........+shp+th.cshcaQlDD.............+PthplRhpppLs.ahs.-tp......hstclPshc.........acPptLsLapcpacsth.ssuhhs...ssssaGhspFphhschhpR...........cp....s.tsQhEs.h+ApuIhShFAWhsAQA.hYpGFhstsDlTcPhsoQsVITDG+haSFaCYQLNTLuLsspsst.sNsRpNhsWGTpuh.LY-p...............l.pcsclhGaN-.....sslppllpFhlNps	.......................................................................................................................................................................................................................................................................................................................................................................................p....hps...h.hhT+Thh........t.L.P.............................................................t...t.hp.h........h...t.................................p......hltpl...hht.h....p...........s.Ltt.t..h.s.p....hthhW.htt...................................hQhps....................pst.tlphtp.Ls.hhs.p............hsh.l..sh..............................s..shls.l.ppp.h.p...h..suhh...........s....hsas.as..ahhh..s.t.....hR...................................................tt.ht..s.h+ApsIhtsFuhshA....pA..th..G...........hps..ps...ls.pPhlsQuV.hTDG+hFpFhsaQLNTlsLss.....ss....s....hKNlsWss.p..sh.LYpp....................................l..pss...t...hhshps.....cshhphlthhh.............................................................	0	45	57	101
+6976	PF07148	MalM		Maltose operon periplasmic protein precursor (MalM)	Moxon SJ	anon	Pfam-B_16111 (release 10.0)	Family	This family consists of several maltose operon periplasmic protein precursor (MalM) sequences. The function of this family is unknown [1].	19.50	19.50	20.60	19.60	18.10	19.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.33	0.71	-4.71	36	702	2009-01-15 18:05:59	2003-09-03 11:41:22	7	2	687	0	64	315	6	135.60	62	45.04	CHANGED	sstpShhAAaplP..uspGshplpLoShl..spslFsPsVllLDpphpssphhssspFpYp.sshhsssRlpuplpls....s.uppphYlllYToppDLstoTpl.cP..AKshAcuhGpshPtlsDssstHossGplclplp	..............................sGIoGPVAAYSVP..ANI..GELTL...TLT.....SEV....NKQs....SVFAPNVLILDQNMTPSAFFPSSYF..TYQcPGVM.SADRLEGVMRLT...PALGQQKLYVLVFTTEKDLQQTTpLLD.P..AKAYAK.GVGN...ulPDIPDPVARHToDGllKLKVK..............................	1	8	22	46
+6977	PF07149	Pes-10		Pes-10	Moxon SJ	anon	Pfam-B_16134 (release 10.0)	Family	This family consists of several Caenorhabditis elegans pes-10 and related proteins. Members of this family are typically around 400 residues in length. The function of this family is unknown.	21.10	21.10	22.50	22.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.19	0.70	-5.69	5	17	2009-01-15 18:05:59	2003-09-03 13:21:49	6	2	5	0	17	15	0	278.90	21	92.35	CHANGED	MNcTEYphHLLARTI+TGcDEhITPlIpQLs-hpVSMDILEKHNlPsLVscaAPaNpsApSLu+slLsWKN-clppEKPplLKcFsctst-c+aP-pFV....L+LLTuLMsF-DL-LV+ssFcILsph-LoL--aEcaGIaE+AtpFQtQhcEADELIsKl-..hLpsEhLEEsEpEpptsclhssh-cc...................u-sESGlFT--E..........cccspcp.llhEICMlaLApCIKoGNs-VISuAIpFsGsacaPLALYRKYDIQhLIYsaGs+s-DAcpLhDaIEclEclElssE+lEAFK+Fl+..sshEp.csVTDSVMolLpGFL........E-sDDahVcsTLcFFLsMPISL-QFcps+VEssLcNLEptssupLullLKhKIp-L+p	...........................Msthph.h.hLA.hltst..p.t.Io....hhp.......L.s.h....hchh-ptNhPhllt.....p.ss....A.ph...hh.hK..phtpE...hhptFht....hh........tt.h...............lpLhh.h........t..p..hhp.sh.hl.t..h.ht.h....h...h.....ph.-t..lh.p..............t.......-..............................................................................................-l.hh.hht.lpstspthls..............hulph...htt.phsLplhpKY-IttLlh.ths.p.pptA.p....Lh.pIpphpp.tht.pp.phh..hhp........t...sshht.h..ah.....................................................................................................................	0	6	7	17
+6978	PF07150	DUF1390		Protein of unknown function (DUF1390)	Moxon SJ	anon	Pfam-B_16182 (release 10.0)	Family	This family consists of several Paramecium bursaria chlorella virus 1 (PBCV-1) proteins of around 250 residues in length. The function of this family is unknown.	20.00	20.00	20.20	20.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.53	0.70	-4.99	25	54	2009-01-15 18:05:59	2003-09-03 13:27:10	6	1	10	0	3	52	2	190.20	31	82.66	CHANGED	csaphslYpCuCGYcTsssuNAoKHKKT.uCsHchpscpc.cFVLcEDh...phtsspshsstshsssss.ssshsphlsp.psIsIsLslP-poshssIh-slps.phhpElcsu.-PppIPAlLF+aTRGht.....utpphI+Y-sDKslVpcKDP.sG+-sspcLKKY+scYls-sssla-cshclsahPpplpcsh+-hppPphssG+KKsc.lsuA-slKhsAoGsHhhYKhPtE	...chaphplYhC.s..CGYcThspusAs+HpKo..pCtcc.hhpppp.pFlhcc-h...t...stsh......t.sshtt...s.pp.lp...phshsLhlP-tshhpslhchlps.ph.p-lpst.pspphPullachT+u.t.....tt.thlphcsDK..lhctc..sGp.htpslpKhtpcah.cssshhppsh.l.h.sp.hpp.hc-hppsphs.G+K+sp.lsuu-sl+.hAsGsHhhYKhPhE................................	0	1	1	3
+6979	PF07151	DUF1391		Protein of unknown function (DUF1391)	Moxon SJ	anon	Pfam-B_16216 (release 10.0)	Family	This family consists of several Enterobacterial proteins of around 50 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi where they are often known as YdfA. The function of this family is unknown.	25.00	25.00	32.20	76.00	22.70	21.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.54	0.72	-4.47	4	588	2009-01-15 18:05:59	2003-09-03 13:43:20	7	1	261	0	3	201	0	48.70	87	78.29	CHANGED	pplDLGNNESlVhGVFPNpDGTFTAMTYT+SKTFKTEuGA+RWLtRpss	..DTIDLGNNESLVCGVFPNQDGTFTAMTYTKSKTFKTEsGARRWLtRNo.s........	0	2	2	3
+6980	PF07152	YaeQ		YaeQ protein	Moxon SJ	anon	Pfam-B_16245 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length which are often known as YaeQ. YaeQ is homologous to RfaH, a specialised transcription elongation protein. YaeQ is known to compensate for loss of RfaH function [1].	25.00	25.00	28.00	26.10	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.87	0.71	-4.94	64	1039	2012-10-11 20:44:44	2003-09-03 13:49:14	7	2	1018	5	215	584	86	173.00	52	96.12	CHANGED	MAL+uTIYKsplpluDhDRsaYpshpLTlApHPSET-ERMMlRLLAaALpAs..E.p....LpFTK.GLS.ssDEPDLWpKsLs.scIplWIElGpPDEcRl+KAss+AccVhlasY.upssplWWpptps+lsphcNLsVhplspsthpsLupLspRsMpLploIp-Gplalosspp..s.lpls.ph	...........MALKATIYKAslNlADhDRsha.hDtuLTLARHPSETpERMMlRLLAahhaAc.....ER.........LpFT+.GLs.s-DEP-hWh+s.c.huI-LWIELGlPDE+RI+K..ACs...pA..tc...Vs.LasY..suRAAplWWpQspuKhspasN....LoVahLD--plupLushA-RTMsLQsTIQ.DGslWLSDscs.s.lElphps.................	0	39	107	166
+6981	PF07153	Marek_SORF3		Marek's disease-like virus SORF3 protein	Moxon SJ	anon	Pfam-B_16263 (release 10.0)	Family	This family consists of several SORF3 proteins from the Marek's disease-like viruses. Members of this family are around 350 residues in length. The function of this family is unknown.	21.90	21.90	22.40	28.80	15.70	21.80	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.12	0.70	-5.77	3	18	2009-01-15 18:05:59	2003-09-03 13:53:59	6	2	8	0	0	14	0	263.20	39	91.13	CHANGED	MSRusAslFDDMDIPRGRFGKPPRKITclNFWslLsDELTsGIVQCMESRERLALlHTsSsN-Go.hSFDIHKDMWCQMVLWSAYRFFSTM-+MFSI-oIoNFs-TDVsEoGpW+IaCRTWDlRDAsKMKhlGPFLPALFSFHLENWTTMLSIGIsKGYDRHNsRshFMshPShKNVLlGAlEVARaAVVLoLPICEYRTPhGLPDDpIGNAIKLCCAQMQANRLEcTGIopDutpKsNDuSEEELYYRslH-LVKouREHCcSsE......sshDlsPTI+cpp.psIphphsSsh.hGhtshuR.hNsGch+Yp+.plhRNhPlRVPRSRLuNSKILQTFRcshsRSsha...l	............sRs.AhhFsshDhPRGRFhpP.h+.sshsaW.hhsDEhspGIhQChEuRERlu.lp..p.spG...paD.phDMWsQhslWSsY+hhthhp+.FSlcplh.hscpslstsu.ath.hpsWDlRDusKh+hlGPhL.AhFShHlENWTshLSIuhstG.asppsphs.hMsh.us+.sslhsuhEVAR.hlVLsLPls-YRsP.GLPDDshGNAI+sCCApMQtpRLpcsths.D....hpsssEEEhYYRslpc....lIpstRcas.ssp.......................................................................................h..............................	0	0	0	0
+6982	PF07154	DUF1392		Protein of unknown function (DUF1392)	Moxon SJ	anon	Pfam-B_16270 (release 10.0)	Family	This family consists of several hypothetical cyanobacterial proteins of around 150 residues in length which seem to be specific to Anabaena species. The function of this family is unknown.	25.00	25.00	172.30	172.20	17.70	17.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.88	0.71	-4.35	7	15	2009-01-15 18:05:59	2003-09-03 13:56:02	6	1	3	0	11	15	0	152.00	43	98.45	CHANGED	Mss.IspLEpCWYlSPPWGpphsPltlsLhE+VYLpos+ohGYCCGVpWppDtW.Ysl.scpshlpsscppIIupGphpshslpKPtFtLG-hV.hcFsscusKpRlILGltLlpsuWhYhVEhhSPsL..............stttsh.pRhuhVp-cDLVpV	MhstIssLEoCWYlSPPWGpplPPltlsLlE+VYLpos+ohGYCCGVpWpc-sWhYsIhsss-IlasocspIIuTGplpsholpKPsFtLG-hV.lcFts-uPKpRlILGl.LlcpsWhYtVEhtSPsL..............opsssh.sRhuhVs-tDLVcV......................	0	0	6	11
+6983	PF07155	ECF-ribofla_trS	DUF1393;	ECF-type riboflavin transporter, S component	Moxon SJ, Eberhardt R	anon	Pfam-B_16301 (release 10.0)	Family	This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells [1,2].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.18	0.71	-4.53	62	2634	2012-10-03 02:46:00	2003-09-03 14:01:05	7	8	1367	0	389	2679	75	161.70	23	88.03	CHANGED	p..ss+plVhhulhsAlhhllsh.h..lpIPss..so....lplspuhlhlhAhlFGshhGhlsGhlGtsLhDhhsG.Ys.hWhsa.llscGlhGhlsGhhspph..php.......hphhs..llhhslhhlhuhhluhsll..................uhtshltulhuslh.pslsuhlluhhLh..tsht+	.............................t..ps+plshhulhs..Alsl.l.lsh....h.......hp...I.PhP................lp..l.s.s.u.h..l..h..lhu..hla..G...s.h..hGh.......l.......l.......Gh.......l.......u...t.h...lt.....D.....h............h....s.G.....Ys....hW...h....s.......a.......p......lls.....p....G.........l..h.....G.....h....l.........s.........G.....h.....h..t.p.p..h.......ph............................p...h.hs.........hl....h....h.s....l....h..t..l....l.u....h..l...s..tslh..........................................t.ss..h.t...s.....h.h...t.....s......l....h.u.....s....lh....ps.l...s....shl....luhlLh..sht.........................................................................	0	159	250	313
+6984	PF07156	Prenylcys_lyase		Prenylcysteine lyase	Vella Briffa B	anon	Pfam-B_12448 (release 10.0)	Family	This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction [1]. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps [2].	21.30	21.30	21.30	21.40	19.80	21.10	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.08	0.70	-5.57	5	325	2012-10-10 17:06:42	2003-09-03 14:06:43	9	14	182	0	225	329	7	298.00	29	68.63	CHANGED	FEEosWalINllKLVWRYGlSsLRM+MWVE-VLDKFMRIY+YQuHcYAFSuVEcLL+ulGtsDalshlppTLpEsLpcAGlSppFlNEhVusVhRlNYGQSsDINAFAGAVSLuuAsuuLWSVEGGNKlVCSGLLptSKuNL.IsuoVpSI.....T+aosNspchYpVsYKssstspSDFYDIVVVATPL..DcshSNIT.FtNFcPPI--hpspYQpTVTTlV+GcLNooYFGs+PhDpFsLusILTTDDuslFhssluIl.....sShRcK.....sscGstVWKlFSRcsLo+sQLccLFpSYshsV+KsW.tAYP+YcsPpppPsFILHD.+LYYLNuIEsAASsMEhSAIAA+NlALLAYcRWNscpDh..IDQcsLhc+LKTEL	...................................................hhshh.+lhW+Y..G.h.t...h+.................hp.hhc...phlpc..Fh.+.l...Y..c..............t...............h.sFps.l.pphh.sh...........G........hhthhptohtc....L.....p.s.G...h.......s.p...pFhp.-lltsshRlNYG.Q.s...s.lsuh.............s..Ghho.hs..s.u.t.s.uhhuVcG.GN.h.l...hpthlp.....t.op........u........sl...l.p.s.p.Vtpl.......................p.ss...s..st........h.tl...........h....p.........s......t.......t.....t......t......t.t..p........h..a....Dh....VllAsPh...p.t.....lt.........s..hp....s.h...p....................a.phhsT.h.h..p...u......l...s..s...phFsh...s..p..hs....t...slhTs..........t.......s.........p........h............h...s.........shh..........................p......................pt.thlaKlFS.p.lp...pp...............lppl.............F......................t...........h........................................s....................p.......h.W............u.......YP..h..h..t...s...........p...h....................s.hhL...ts.....t............l.....aYhsuhE........hh.SsMEhsuluucN.sAh.Lhh.pph......................................................................	1	73	112	170
+6985	PF07157	DNA_circ_N		DNA circularisation protein N-terminus	Vella Briffa B	anon	Pfam-B_12343 (release 10.0)	Family	This family represents the N-terminus (approximately 100 residues) of a number of phage DNA circularisation proteins.	19.90	19.90	19.90	20.10	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.94	0.72	-3.85	9	365	2012-10-10 17:06:42	2003-09-03 14:09:03	7	3	318	0	54	329	4	93.30	41	21.62	CHANGED	h+cthtcASFRGVPFhlEc-p.tssGRRl.hHEYPhRDpshsEDhG+phpphplouhllGcDhhspR-+...Ll-AL-psGsGpLVHPhaGphpVpl	...................................WpcpLtcASF...RGVPFhV.psp..sssGRRlthHEYPhR..Dp.sasEDLG+tspphslsAhll.......Gc.......D.......hhspR-.c...LlsALc........psGsGpLVHPhaGchpVtl.................	0	13	25	43
+6986	PF07158	MatC_N		Dicarboxylate carrier protein MatC N-terminus	Moxon SJ	anon	Pfam-B_16346 (release 10.0)	Family	This family represents the N-terminal region of the bacterial dicarboxylate carrier protein MatC. The MatC protein is an integral membrane protein that could function as a malonate carrier [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.64	0.71	-4.39	5	578	2012-10-02 15:12:49	2003-09-03 14:11:11	6	4	502	0	89	495	47	146.70	43	38.33	CHANGED	MssELloILlLllsFlIATspsINMGALAFAuAFllGolllGLcscElLAGFPuDLFLTLVuVTYLFAIApsNGTlDWLV+sAVRtVRGRluAIPWVMFllAuLLTAhGAluPAAVAIlAPVALoFAs+YRIcPLhMGLMVlHGAQAGG	.........................................................h...pllhl.Al.sluIuIG.a..h.pKIN.IG...llA..Is..Fu.Y...lIush.h..M.........G.l.sP.........K..-..l..l....p.......h..W...P..s..u..l..F...FsIhu..V..SL..F....as.h...A.psN.GTL-hLAp+llYRs.Rs.+..Ps.h.L....P.hll...alhusll.oALGAG..aas..s..hA.l...hs....P..lAlhlCpKh..s.hsP..L...lGAhsl.saGApuGu.........................	1	27	59	69
+6987	PF07159	DUF1394		Protein of unknown function (DUF1394)	Moxon SJ	anon	Pfam-B_16260 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 320 residues in length. The function of this family is unknown.	20.10	20.10	21.10	20.20	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.84	0.70	-5.30	7	319	2009-01-15 18:05:59	2003-09-03 14:55:21	7	7	109	0	197	239	1	249.30	46	56.05	CHANGED	tsphFLDFENAQPTEsE+ElappVstVLpcu-ulLt-LpuY+GAupEIR-AIpNPss.phQEcAWpuVsPLVsKLKcFYEFSlcLEpsL.pLLtuLs......uss.sPppHLE+cQALAKQFAEILHFTL+FDELKMpNPAIQNDFSYYRRTlSRpRlsNh..-sEscVsNEhANRMSLFYAcsTPMLKsLScAToKFVSENKoLPlENTTDCLSTMAsVC+sMLEsPcapSRFps.EETlhFChRVMVGVIILYDHVHPVGAFsKoSpIDhKuCIKVLK-QPssosEGLLNALRYTTKHLND-oTsKpI+	..............................t.phFlDFE.....sApP.o-t.Epplaspl.shVLp-.upslLt...................cLpsY.+.GA.uppI............R..c....A..I..p..s..P..sc..........plQ..E+AWsuVsPLVsK..LKcFYcFSh.+...L.-pslpsLLttLs......ss.h.s.s..ppaLE.cpQALsK....phAEILcFsLpFDELK...MpsPAIQNDFSYYRRsl...S..R....+...l.....s..........s..................-....-.spl.....ssEhAN+...MS.LFa..ApuTPM.LK..sLSpAT...cFVs.-..sp.s.sl-ss.o-sLuThs.s.VCthMlEsscahsphps.p-oh.hshRVMVGhlIL..YDalcs.GAFs+t.u.plch+....ssl+lL...p.t.ps...................tspsLLssL+..aoopHhs.p.sTsttl...............................................................................................	1	66	85	147
+6988	PF07160	DUF1395		Protein of unknown function (DUF1395)	Moxon SJ	anon	Pfam-B_16376 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 250 residues in length. The function of this family is unknown.	25.40	25.40	26.30	36.90	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.54	0.70	-4.87	6	100	2009-01-15 18:05:59	2003-09-03 14:57:27	7	3	84	10	70	109	0	220.70	30	87.04	CHANGED	+ls.l+Ell.hRshh.sPshcsTLSsIssslsulchLLpchcp.lpppcps.sptKcLhpsohcpppch.tlctpsPsphs.csp.ssppssspsLlpcst....t.........cEpu.sppP.+ps...+.h.aITs-EFcSlPsYM+GRLTL-plNthlschssalsuKs+IlupspKpLocssRElhpcaR-lEsKsst+..G+aFFlEsDIKshssLKLDpoFtshlssLRHlpRlpEsRsGsLT	.........................................................................................hpc.l.............ss.hps..Lptlspp...lhslpphLpphchplp.pc.p.t.sphKcLhpshppp...c.cl..pclppp.lP...spl.....P...................ts....ps.s..psh.h.p..t.st.ts.pt.....................hpsp.p.t...spcs.+....ct..c........lt......ph.a......ITs-EFsulPpYM+GRLT...h-plNssl.p.-l.Nps.lhuKY+ILppP.+...K..s..hs.ss.s+p.......hhpca.h.-p.E..s..K-op...G.paFhlEsDI+ch.s......slK.lD.+p..h+.slLslLRHhpRlpElRsu...................	0	18	30	50
+6989	PF07161	DUF1396		Protein of unknown function (DUF1396)	Moxon SJ	anon	Pfam-B_16343 (release 10.0)	Family	This family consists of several putative lipoproteins from Mycobacterium species. The function of this family is unknown.	24.00	24.00	24.00	24.00	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.03	0.71	-4.64	17	288	2009-01-15 18:05:59	2003-09-03 14:59:51	8	1	134	7	53	132	1	191.50	36	78.19	CHANGED	Dsstl..lpcuspsT+slpSsHlsloVsGp.....lssL.slpol-GDlTssPtss..ApGssplhht..uttl.sscFllsDuslYssls..ssasshGsu..tslYDsuhl..LsP-pGlusVLu.shssspspGcEslsGpsTs+l....oGslsAssVstIsPs..hsus.tslPsTlWIs--..................sstpLspstl.chssGss....VplTlScWscsVsV	...................................................................................................-At.L..lcpuscAT+slpSs..HlslsVsGc..............lssL.....slpo...l..-uDlo.s..sPt.s...ApGssplhht......sssh...sscFlVh.s.splYsc...Ls........ss........aosh..Gsu........tsl...Yssuhl......LDPs.pG...........L.........uslLu.slp.ssps.pG..p-sID.Gl...sT.s.+l...............oGsls.Ass............lst..ls...Ps...............hsp......s...t.lPsTVWIsps..................Gs.pp.LVphpl...-hspGs...........VplThScWGc.Vsl..............................................	0	18	43	50
+6990	PF07162	B9-C2	B9;	Ciliary basal body-associated, B9 protein	Vella Briffa B, Coggill P	anon	Pfam-B_12595 (release 10.0)	Family	The B9-C2 domain is found in proteins associated with the ciliary basal body. B9 domains were identified as a specific family of C2 domains [1].  There are three sub-families represented by this family, notably, Mks1-Xbx7, Stumpy-Tza1 and Tza2 groups of proteins. Mutations in human Mks1 result in the developmental disorder Mechler-Gruber syndrome [2]; mutations in mouse Stumpy lead to perinatal hydrocephalus and severe polycystic kidney disease [3]. All the three distinct types of B9-C2 proteins cooperatively localise to the basal body or centrosome of cilia.    	20.80	20.80	20.90	21.10	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.95	0.71	-4.47	45	444	2012-10-10 12:23:49	2003-09-03 15:04:25	6	10	128	0	283	416	10	153.90	27	49.58	CHANGED	clhlhGpI.uAp...sapps.sL..............as+atlhtGs.sWp...........hlsGhp...................pGtTQhshsss...schsh...............asaPh-lphpsps.pG..................................WP....pLhlplau................hDshG+.ppltGYGhstl......Php.sG.pHplplshW+.P.......hsohhppLpphhlGusPpLpc..shlts..........spsRhtl+oco.sGpVplplsllh	.............................................................lhl.Gpl.sAp...thp..s..sL..............as+atl.hGt.....s.......Wp............hsG.p.....................pGhoQhsps....pt......s.phsh...................asaPl-lphtsps..G..................................WP......plhhpVhu.....................D..a.sp.phltGYGhshl......P.......h.......s..PG......p..........Hph........ph...s......hapP..............................ss..h..hpphtp.....hhhGttsphtc..phltt....................t.sR.h.hp.sts..tG..lphphphh.h.......................................................................	0	122	153	228
+6991	PF07163	Pex26		Pex26 protein	Moxon SJ	anon	Pfam-B_16379 (release 10.0)	Family	This family consists of Pex26 and related mammalian proteins. Pex26 is a type II peroxisomal membrane protein which recruits Pex6-Pex1 complexes to peroxisomes [1]. Mutations in Pex26 can lead to human disorders [2].	25.00	25.00	41.60	29.00	22.30	20.50	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.93	0.70	-5.52	3	66	2009-09-11 08:51:28	2003-09-03 15:14:33	7	2	40	0	27	66	0	266.40	54	93.40	CHANGED	MKSDSSTSAAPLRGLuGPLRSSEPsLAlPAsuPAVcLLEEAuDLLVVHLDFHAALETCERAWQSLssaA.AEEP.uGTplEVKCSLCVVGIQALAEMDRWREVLSWVLQYYQVPEKLPPKVLELCILLYSKMpEPGAVLDVVuAWLQDPuNQulP-YGoLAELHVhRlLLPhG+LSEAEELl...VGSAAFoEEQRl-ALQAIHsARQQpspppoQEHSsSp.......EsQKlspEGSlSpKLLSLlMLLRRLWuSAVSHlhSlPFRKuLLAALILCLLIlRFDPAuPSSLPFLY+LsQLFpph.pAshGRLYhLAsRS	...................................M+SDsSsSuAsh+GhsGsLRSSEPstssPshusAV...sLLEEAADLLVVHLDF+AAL-TCERuhpSLss.s.sEEs.suoslEVKCSLCVVGIQALAEMsRWpEVLSWVLQYYQVPEKLPPKVLELCILLYSKhpEPuAhL-VsuuWLpDPuNQsLPE.YsuLAEhHl.+VLLPLGploEAEELl...VGSsAFsEEpRhssLpslcpuRQQ......ppppcs..uo-.............Espc.sp-...G...uhspK.h..Lul.hLlpphhssuso...+hhShPF++uhLAALlLsLLllRhDP.AuPSSlsal.+Lh...pLhp.h.tuh.u.h..............................................	0	4	6	13
+6993	PF07165	DUF1397		Protein of unknown function (DUF1397)	Moxon SJ	anon	Pfam-B_16395 (release 10.0)	Family	This family consists of several insect specific proteins. Swiss:Q25513 is annotated as being a haemolymph glycoprotein precursor. The function of this family is unknown [1].	24.90	24.90	24.90	27.40	22.10	24.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.74	0.70	-5.14	17	111	2009-01-15 18:05:59	2003-09-03 15:42:10	6	3	35	0	77	116	0	191.90	28	72.67	CHANGED	-l..p.s..php..-lpchlcspCpcss.....GsDp...happlEpusps.hscClpGllDhsslppEIccApPsG-LDpVFsKYCt+tspuhpClsshpstlpPCL-p--ppphsshhshhppLLsFlCaK-GDpIALFIAEpGPEChpppp-sltpChspshsua.......sshp.up.hshsc..hu.pQCs-hsphpsChlccLEpCpssTPuNlsEShF+alR+toPC	........................................t..phtphpphhppcC.css........usst....hhpplppuhhp.hspClpshhs..hsthptEhpp.spPpGs.LDsVFpK.........YC..+hs.p.uhpClpsFsstlpsCLsp.-Eppt...s..hhhplhpplLsFlCh+sGDpIAl..FlucpGsEC.....hppp.pcslt.pChs..pshsth................psh.phs..p........thsp......hs.cpCs-ltphcsCllpc.LE.p.Css.s.suNlh-uhFchltptosC..................	0	23	31	67
+6994	PF07166	DUF1398		Protein of unknown function (DUF1398)	Moxon SJ	anon	Pfam-B_16404 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Escherichia coli and Salmonella species. The function of this family is unknown.	20.80	20.80	21.00	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.59	0.71	-4.23	6	734	2009-01-15 18:05:59	2003-09-03 15:46:05	6	1	607	1	25	177	1	121.40	41	91.93	CHANGED	QlllFpchF-pVRpDhNaphFYSELKRHNVSHYIYYLAT-Nl+IVhcNDssVLlKGt+pllpV+ho+NppLIcsost+ahStEloFpcYpcsLAsAGVFRWITslcEpKRaYYohDNoLLapEsl	...........................................hhhpchF-pVRp-.NFshFa...p-LKcpsluaYIYalATsNl+Ilpcs-sslll+us+s..llpVssopNpshIcpshttHhsGcpoFcpYCssLApAGVF+WlsDlppppRpYa.shDNpLLahEsl...........	0	11	15	22
+6995	PF07167	PhaC_N		Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	Moxon SJ	anon	Pfam-B_16456 (release 10.0)	Family	This family represents the N-terminal region of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulfur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond [1].  This family appears to be a partial segment of an alpha/beta hydrolase domain.	20.50	17.00	20.50	19.00	20.40	16.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.98	0.71	-4.83	37	1217	2012-10-03 11:45:05	2003-09-03 16:00:08	8	8	704	0	326	1286	296	145.90	45	28.33	CHANGED	.pD+RFusssWppNPhachltQsYLlsu+hlpphl-ps-..lDscs+pRscFhscQhssAhuPSNFlhoNPpsl+cslposGpSLlcGhppLhcDltputu..plppoDpsuFpVG+NlAsTsGpVVacN-LhpLIQYcPtTEpVac+PLLlVPPhINKaYILDLpPpNShlcas	.......................................tD+RFts.sWptpPhaphhhptYLh.tchhtphhpshp...ls.ppcp+htFhhpph.hsAhuPo.NhhhhNPt.hhcphhpotGpsLhpGhtphhpD...l...tps.t......h.p..ss.t.psFpl..G...c.....sl..A...s...TsG.pVVacNclhpLIQYp.P...h..T.......c....p....V..h.t.p..PlLIVPPhINKaYILDLpPcNShl+ah...................	1	81	187	258
+6996	PF07168	Ureide_permease	FAE_3-kCoA_syn1; Ureide_perm;	Ureide permease	Vella Briffa B	anon	Pfam-B_11634 (release 10.0)	Family	Heterocyclic nitrogen compounds may serve as nitrogen sources or nitrogen transport compounds in plants that are not able to fix nitrogen. This family represents ureide permease, a transporter of a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine; it has 10 putative transmembrane domains with a large cytosolic central domain containing a 'Walker A' motif. Ureide permease is likely to transport other purine degradation products when nitrogen sources are low. Transport is dependent on glucose and a proton gradient [1].  The family is found in bacteria, plants and yeast.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.11	0.70	-5.76	4	165	2012-10-02 19:55:49	2003-09-03 16:15:55	6	4	88	0	57	194	24	229.70	39	66.75	CHANGED	MlLuLhFLGTWPAlLTLLERRGRLPQHTYLDYolTNLLAAllIAhohGEIGtspPscPsFhTQLsQDNWPSVLFAMAGGllLSlGNLuoQYAaAFVGLSVTEVITASITVVIGTTlNYFLDs+IN+AEILFPGVuCFLIAVFLGSAVHuSNAuDsKpKL......pshps.pp.tolpshEhcsh.....ppp-LEpGc..s-pscsGTAsFllELEc+RAIKVFGKSphIGLslThhAGlCFSLFSPAFNLATNDQW+TLc+GVP+LsVYTAFFYFSISsFllulILNlpFLY+PllGLP+SSlKAYlsD.sGRtWAlLAGhLCGFGNGLQFMGGQAAGYAAADAVQ	.............................................................hlohlhhGoWsshhpLhp++tRh.ph.hYhDYols.lLsullhAhThGphG....ps.sFhspL..s..Q..sshsSlhhAhhGGllhsluNlhhphAhAhsGhSVs.slu..sulslVl.GsslNYhh...s.sph..scs....lLFsGVushllAl.hl.s..uh.sat.............................................................................................................................................................................................................................................................................................................................................................................	0	18	39	47
+6999	PF07171	MlrC_C		MlrC C-terminus	Vella Briffa B	anon	Pfam-B_6316 (release 10.0)	Family	This family represents the C-terminus (approximately 200 residues) of the product of a bacterial gene cluster that is involved in the degradation of the cyanobacterial toxin microcystin LR. Many members of this family are hypothetical proteins.	25.00	25.00	30.90	30.80	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.84	0.71	-4.71	15	567	2009-01-15 18:05:59	2003-09-03 17:08:38	7	6	358	1	215	590	412	175.50	31	35.98	CHANGED	llADstDNPGGGusGDsTtlLcullc.Rshpss......ulusIa.DP.AVptstAAGtGAslsL+lGGKhustuupPlcscspVp+Lscsshps....htss.hslGssAsl+lt..G..lclIlsosRsQsa-.shFpslGl-PtspclLVVKSusHF+AsFtPlAppllhstuPuuhssDsspLsa++l	........lluDstDNPGuGusuDsThlLctLl.c...p.s..h..pss...............shuslh.DP.t...Asp..tshsA....G...h..........GApl.slplGu...+.....s....s....s....h....s....u....t...Pl..c.spspVtt..lscsthhs.........hts..t.h.p.hGssA.slcls......G.....lc....lllsop+p.phh-.shFpthGl.-Ppp.tc..llVlKSs.aa+u......sFts..lA..s....t.ll.hstuP..Gshs.p.Dhsplsap+.................	0	35	109	166
+7000	PF07172	GRP		Glycine rich protein family	Bateman A	anon	Pfam-B_15819 (release 10.0)	Family	This family of proteins includes several glycine rich proteins as well as two nodulins 16 and 24.  The family also contains proteins that are induced in response to various stresses.	30.00	30.00	30.50	30.20	29.80	29.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-11.19	0.72	-3.51	15	154	2009-09-11 20:33:22	2003-09-04 11:05:36	6	3	52	0	60	154	0	95.50	33	73.37	CHANGED	MA.SKA.hlLLGLhhsssLLluSEVuAtp.......usp.KsEscssVpssph.....................ttGGYsGGGGsthsGGGh.sGGGsass........................GttGh.tt....GGGYpGGG	...........Mu.SKs..hlLLuL.hhAslLLluS-VuAtc..........ttt..ps.p.sp..ss.....Vpssphhu..t.t....................ttGG.....as..GuG..Gt...t..........G.....G...G.....h.........ss.s.G..u.asG..............u.G..tGh..st.......G...tGh....t.................................................	0	12	34	47
+7001	PF07173	DUF1399		Protein of unknown function (DUF1399)	Vella Briffa B	anon	Pfam-B_13062 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within a number of hypothetical plant proteins of unknown function.	21.20	21.20	21.20	21.20	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.83	0.71	-3.88	16	332	2009-01-15 18:05:59	2003-09-04 13:51:26	7	9	120	0	256	357	6	114.40	26	21.11	CHANGED	pYpp.Ccphas+l.l...sptultsphppp.uh.pscclWpphaPpEsachphsstos.......tsstplspDLlusVhRQppFst+hs.......oPahp-s.aLppAhtRYptFlpllpp.tspc...hhLVPThDIDLhWHTHQLashsYhsD	.........................................................................................................................................................................hshDLssulhRQtt.F.htphs..................................pshht.p..s..lpcultRYp.t......F.ltlhpp....psp............thlVPTLDlDLhWHTHQL.sP.htYhp....................	1	86	161	234
+7002	PF07174	FAP		Fibronectin-attachment protein (FAP)	Vella Briffa B	anon	Pfam-B_16585 (release 10.0)	Family	This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix [1].	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.20	0.70	-5.12	8	90	2009-01-15 18:05:59	2003-09-04 14:53:17	6	4	83	0	15	77	0	271.90	62	85.80	CHANGED	McQsDspupRR+GL.soLAlAAVoGAoA....sulALPAsAsADPs.PsPs........sPPususAsPAPssP..sPuPsssPs................PuDPNAssP........P..ssADPNAPsPPPsDPNAPsP........ssPpsGRlDNAsGGFSYVVPAGWh.SDAopLsYGpALLSKhssEss.PspsPP..NDTpVlLGRLD.KLaAuAEsDNsKAAsRLuSDMGEFFMPaPGTRlNQpTlPLc.ANGhsGsASYYEVKFoDsNKPNGQIWsGVVGsPsAsusscG..sPpRWFVVWLGTANNPVDKuAAhsLApSIRPWsPPP.PPPsssPus	...................................McQVDss.TRRKGhhAsLAIA.AhuuASh....VTlAl...P.A.T.A.sADPE....PsPs.............ssPPS.TAsAP.......P.A.P.As.PsAPP.sPuAss.sPt............spPuDPNAAPP..........P.....AD.PNAPPP.PslsPNAPt.P..............sRIDNsVGGF.SFsLPAGWV...ESD.AuHLDY....GSALLSKsTG-PPhPsQPPPVANDTRIVLGRLDQKLYASAEAssoKAAsRLGSDMGEFaMPYPGTRINQETlsLD.ANGsoGSASYYEV...KFSDsSKPNGQ.IWTGVIGSPsAsussuG.....sPQRWFVVWLGTANNPVDKGAAKALAESIRPhssPP.PsPAPAPut..................................................	0	2	8	12
+7003	PF07175	Osteoregulin		Osteoregulin	Vella Briffa B	anon	Pfam-B_16589 (release 10.0)	Family	This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition [1].	22.10	22.10	22.60	38.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.87	0.71	-4.42	3	78	2009-01-15 18:05:59	2003-09-04 16:19:44	6	1	41	0	14	72	0	174.70	55	34.65	CHANGED	csNED+SSu..................GNQ-NIHpsLtASVYP-PTVsKGTEDGcDAlLHLhDQ-RYGAALLRNITQPVKSLVTGsELpuEcNKEK+PQSVLSVIPADVNsAKsaSKDpKNQQRDLLsQsSPVKS...KHT+RsRRSTHYLTHLPQIKKIPSDFEGSGSPDLLVRGDNDVPPFS	.........................................p..sEsptSs..................oNKENsHssL+MSIYPcSTGN+GsEDGDDAlSKLHDQEEYGAALIRNNMQH.lM.uPVTshc...L..LGEENKEsKPRNVLsKIP..Auh..NYAK.ApSKDK.Ks.QRDuQuQpsPVKS...KST...H+..hQHNhDYLKpLsKVKKIPSDFEGSG..YsDLQpRGDNDlSPFS.............	0	1	1	1
+7004	PF07176	DUF1400		Alpha/beta hydrolase of unknown function (DUF1400)	Vella Briffa B, Bateman A	anon	Pfam-B_16606 (release 10.0)	Family	This family contains a number of hypothetical proteins of unknown function that seem to be specific to cyanobacteria. Members of this family have an alpha/beta hydrolase fold.	23.00	23.00	23.20	24.10	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.45	0.71	-4.22	10	255	2012-10-03 11:45:05	2003-09-04 16:53:21	6	4	69	0	99	279	187	126.00	27	30.55	CHANGED	AAEplsLpYuPFpc.olsVp-LppFAcTGplsssL+hahphl..sspphppLRthLspRhplsPVtlupll....sSPlGcplLsplupllpssscpssthALRuAllpuAssPs.GlollsllpsYPopslcls	...............AAEplhlpa.us.hph..o...lsl.......psLcpaAc.s.......G.p....h.s......s...p..Lphahphh...stpp..hpplRphLppplpl..........ssshhsphL....po.hGctlLpp.l.upl...l...p...st.s...s.......p..s...uh....AlRu..All.pu.At............p..sp..slollshLcsaPspslpls............	0	6	65	95
+7005	PF07177	Neuralized		Neuralized	Vella Briffa B	anon	Pfam-B_16611 (release 10.0)	Family	This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system [1]. Some family members contain multiple copies of this region.	20.50	20.50	20.70	20.60	18.80	20.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.18	0.72	-4.10	6	930	2009-01-15 18:05:59	2003-09-04 17:04:25	7	17	92	2	581	865	1	68.60	35	23.45	CHANGED	PLp.FHs.s+GuNlplscstplA+R.cuSFCculsFSsRPltIsEpltl+lt+hppsWsGuLRlGhTspDP	............t.hp.FH..h+Gpplp.lss.ss.p....sAp....R......p...s..s.Fsp...G.lVaSsRPL+ssEhhpl+l..sch....s.s.p..Wu....G.ulclGlTshsP..................	1	163	205	374
+7006	PF07178	TraL		TraL protein	Moxon SJ	anon	Pfam-B_16378 (release 10.0)	Family	This family consists of several bacterial TraL proteins. TraL is a predicted peripheral membrane protein which is thought to be involved in bacterial sex pilus assembly [1]. The exact function of this family is unclear.	20.80	20.80	20.80	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.11	0.72	-3.97	22	417	2009-01-15 18:05:59	2003-09-05 09:50:48	6	2	336	0	58	226	12	91.80	35	93.44	CHANGED	cpYphPcpLscsp+lhhaslDEhls.hllhashGhhss+...hlhGlhlushhahul++hKtGcussalhchhYWaLPsshht..h+tsPsSphRhals	.........achPcpLssts+hhhhslDEllP.shlslshG.lho.u+.......hL..hGl..ss..ulllahsh++.hKcG+usuaLhchlYWahPsshht....h+slPsSphRpal....................................	1	15	31	46
+7007	PF07179	SseB		SseB protein N-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_16678 (release 10.0)	Domain	This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli [1] and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon [2]. This entry contains the presumed N-terminal domain of SseB.	19.90	19.90	20.30	20.40	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.52	0.71	-4.30	133	1525	2009-01-15 18:05:59	2003-09-05 10:51:25	7	20	1195	0	280	1063	109	116.10	25	48.96	CHANGED	Lcpslp...th..tps........ttstpthhptL.....hp.....uclhlPl.spsss.................................tt...tsphphh.hlp....tt-Gpp.....hlssFTohcplpphts.........pttsh.hshshpslhphh.......tps.tulllNPtss.t....thhlstptlttl	.................................................thLtts.tsc.......tpp.thhcsL........hc.....uplaVPsssstsp...................................p...ssslsl..phc.........pp-.Gps.....hlPhFToh-tLpphsp................cppsh..hsh...sscsLhphhh.......ts.p...slhLNstss.s........sh.h.sctlt............................	1	77	194	247
+7008	PF07180	DUF1401		Protein of unknown function (DUF1401)	Moxon SJ	anon	Pfam-B_16789 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 135 residues in length. Members of this family appear to be found exclusively in the Enterobacteria Escherichia coli, Citrobacter rodentium and Salmonella typhi. The function of this family is unknown.	25.00	25.00	25.00	26.40	24.10	24.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.96	0.71	-4.43	2	589	2009-01-15 18:05:59	2003-09-05 10:56:52	6	1	423	0	13	126	0	109.00	50	76.67	CHANGED	hsupsppsshhIPsSV+pYsGEPLYIlVuhWChLQppWlpRNpIAEAFtIshRRASalIsYlpp+pp+ls.hsRa.ohsN.+h+RhEIalhcV..pssP.pp..psGP....KR...RVGNG.hu.uN.lWNch........Ih++Kc-p	...............h.t..................Ys-+PLYLLIA-WMMAENRWVhAREIShpFDIEHsKAlNTLoYIL.S.E.V..sEIsCEVKM.....................................................................................................sp..uttspppphlhhVs.................................	0	1	4	10
+7009	PF07181	VirC2		VirC2 protein	Moxon SJ	anon	Pfam-B_16860 (release 10.0)	Family	This family consists of several VirC2 proteins which seem to be found exclusively in Agrobacterium species and Rhizobium etli. VirC2 is known to be involved in virulence in Agrobacterium species but its exact function is unclear [1,2].	25.00	25.00	57.70	57.50	19.60	15.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.28	0.71	-4.91	5	16	2009-01-15 18:05:59	2003-09-05 11:12:19	6	1	9	1	4	13	0	179.10	54	99.72	CHANGED	MGIRKPALSVuEARRLAAARPEIVHPsssluSQ-sAsspLPE+AG+EDRpssPssAKRpcSsDRQSMLTVDALSSosuPEKlQVFLSARPPAPEVSKIYDNLILQYSsSKSLQMILRRALuDFEsMLADGSFSsAPKSYPIPpss.EKsVIVQTSRMFPVSLLEVARNHFDPLGLETARAFGHKLATAALASFFAcEKso...+sp	MGIRKPALSVuEAR.RLAuARPE...Il+Ps.slso.psssssphPEcucpc-RpstPssAcRptssDpQshL.....TVDALSossuPEKlQVFLSARPPAPtVSchYDsLlhQYSsSKSLQMILRRALsDFEsMLtDGSFptAspSYPIsp.s.pK.llVQTSRMFPVsLlElARsHFDPLGLETuRAFG+KLATAALASFFstEKss...t...	0	1	3	3
+7010	PF07182	DUF1402		Protein of unknown function (DUF1402)	Moxon SJ	anon	Pfam-B_16561 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 310 residues in length. Members of this family seem to be found exclusively in Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.	20.10	20.10	21.00	24.80	17.80	17.50	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.80	0.70	-5.54	9	105	2009-01-15 18:05:59	2003-09-05 11:14:38	6	2	93	0	23	69	1	300.30	69	93.33	CHANGED	shhsssssApAhplVPsGNRsAEQPsIPGASuRRT+AspToa-tKYcKVhsLLpsD+sLhuKI+psAuAYGIDPIHIVGAIVGEHTYNVDAYDRLQoYYVKAhSYuupsFpFuYcGEslspFlpRPpFupCtt...hp-SYsLWSCREsVWsssFRGKoVsGpuaPssRFuAsFFQPFYAGQTFGLGQlNPLTALploDhVsRlSGa.KLstscspuVY+sIMDPDlSLsYlAAhIRcSIDAY+pIAshDIStNPGlTATLYNVGsPcpRAssLtspNp....uGtt.hLPpENYYGWLVNDKL-EL+uLL	......uh.hluSpuAcAlTVVPPGNRNAEQPsIPGASA+RT+thSTTYE+KY.QKIYsLL++DuSLRuKIRSTAAAYGIDPIHIIGAIVGEHTYNVDsYDRLQTYYVKAhSYlspulSFGYsGESIuQFlcRPEFAsCh+...hKDSYSLWoCREsVWNu-FRGKoVGGKAYPNNRFSAVFFQPFYAGQTFGLGQINPLTALQMSDMV.NRlSGLPKLDADDuNAVYKTIMDPDLTLPYIAAoL+pSIssYRpIADFDISKNPGITATLYNsGGopARAcsLAsENu+R+AAGpEPhLPpENYYGWLVNsKLDELKALF..	1	3	10	14
+7011	PF07183	DUF1403		Protein of unknown function (DUF1403)	Moxon SJ	anon	Pfam-B_16581 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 320 residues in length. Members of this family are mainly found in Rhizobium and Agrobacterium species. The function of this family is unknown.	21.80	21.80	21.80	24.40	20.00	21.40	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.88	0.70	-5.05	19	66	2009-09-10 21:27:44	2003-09-05 11:24:43	6	2	36	0	25	69	7	256.30	41	97.24	CHANGED	phs...ssusss.sh.PplPuWltstss-............s.p-sAFtuGAALssLDsllR..ppssWtGsWRpRLALcuAssss+htGRsE-EsuLRDAlhLppsGD..cPGPAGclahAWRcLsppsss...s...lhtlsshLG.....culuslsspltsh....hpuspsuPl.suAtlhuslhshtPpAElluhhLADslLAppLsWs+slPLLusph......t.shRsh.sstsclR.scsshtpAlphAlssuAspAlR.AsElsRRAs+LhAVAPKLRuKGAssslchlLs-DAlsu..........S.....shstLSchAARRLF-RLhsLGAVRELSGRsoFRlYGL	..........s.............s.hPuWshstttp..............s.pDsAFhuGuALssLc.llp.....tp.s.tuhhRpRLALpuAtsssth.GRsEctssLRDAhhLhtsGD...sGPAGphhhuaRphstpsss...........ht.ls......culsslssth.th....hpsttsssh.tuA.hhtthht...s...pu.........-hhuhhLADhsLAptLsWs+.VPLLusth..................ttsclp.tttsh.hAsphAlhpushpAlc.us-lsRRAt+LhAVAPKLRuKGAstslphhLscDAlss.........u.....shs.hschAARRLh-RLhpLGAVRELoGRsoFRlYGl..............	0	1	16	22
+7012	PF07184	CTV_P33		Citrus tristeza virus P33 protein	Moxon SJ	anon	Pfam-B_16614 (release 10.0)	Family	This family consists of several Citrus tristeza virus (CTV) P33 proteins. The function of P33 is unclear although it is known that the protein is not needed for virion formation [1].	25.00	25.00	247.30	247.20	17.40	16.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.00	0.70	-5.59	2	230	2009-09-10 15:37:21	2003-09-05 11:29:21	6	1	1	0	0	186	0	201.30	88	100.00	CHANGED	MFAFASENQDlLEEKIFRRRThHRKYhDDVVRDFTIDlGYDhVDRDPTVLADYhSLYFFLLNND.lGPLAASIhVSPPVsGTHKIRAHlDNQPNpEGNVTYlKTVDKSRFsIhIKAhPAsMRGaYShRAFLuuDVsStpsEFICSFVGSRFLCCsTQTISENLsKVCSSSF.FRsVScTAhNEFSVshDDVEDVKYVRKRAEGF.HCADPYPPRCYRssNLGDsSGVQSRTIEEEGYRTDTsGNVAVolPNTPLVNAVSPYVAEYNENsRSRISLIRRVCCYAVCVLVVSLLIMSGLLsIIhI	MFAFASENQDlLEEKIFRRRThHRKYhDDVV+DFTIDlGYDssDRDPTVLADYFSLYFFLLNNDNlGPLAASIlVSPPVsGTaKIRAHVDNQPNpEGNVTYVKTlDKSRFsI+IKAlPAsMRGYYSFRAFLouDVASERSEFICSFVGSRFLCCCTQTISENLuKVCSSSFFFRAVSETATNEFSVsTDDVEDVK................................................................................................................	0	0	0	0
+7013	PF07185	DUF1404		Protein of unknown function (DUF1404)	Moxon SJ	anon	Pfam-B_16616 (release 10.0)	Family	This family consists of several archaeal proteins of around 180 residues in length. Members of this family seem to be found exclusively in Sulfolobus tokodaii and Sulfolobus solfataricus. The function of this family is unknown.	27.00	27.00	27.50	27.50	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.02	0.71	-4.68	14	66	2009-01-15 18:05:59	2003-09-05 11:40:19	6	1	19	0	23	53	0	153.20	32	84.69	CHANGED	hhslhLllhslNPaoEph.hhsshlaMhuHYuLahuGhLlGhhhh+t.....shhh..hl..............lGhhhslhWHlPhaFsluus.h.hRllp-loLllGGlLhGuShpthshhhK.lsLhuLWMhuDohLuIlhllusshYosh.h.aSPYssppLshsGlhMFlhMsllhsallh+h.l.Ksl	...........................................hhhhhh.lNPhs..h.....h.hMhsHY.lhhuGhhluhhhh+t...............s.l...hh................lGhh.shhWHhPhhFslusthhhhRllpclohhlGGlllGSulptlphshK.lhLhuLWMhGDolLullLhlusshYos....h.sYsspph.hsuhhMFlhMslhhhhllhch.hpt.....................................	0	3	4	18
+7015	PF07187	DUF1405		Protein of unknown function (DUF1405)	Moxon SJ	anon	Pfam-B_16845 (release 10.0)	Family	This family consists of several bacterial and related archaeal protein of around 180 residues in length. The function of this family is unknown.	25.00	25.00	41.90	41.90	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.09	0.71	-4.52	31	478	2009-01-15 18:05:59	2003-09-05 13:01:54	6	1	459	0	77	287	1	164.10	48	83.05	CHANGED	TlaG.ahWY............t....QLspTPhhha.FVPDSPsAoLFhslsLluhL...............hs+sh.....shlcALAhVsLlKYGlWslshplhhhht..s..sshshhthhLllSHhuMulpuhLah.ah.+hphhtlslAslWhhhNDslDYhhh..hPhhsh.ht.a.hspluhhs.............hhlulhslhlshaLshp	....hIYG.YIWY............u...pQL....scT....P....h.....hFhlFVPDSPTAhLFhllulhhhL...............hpKp..........ulI-ALAaVTLhKYGlWAVlMNllhhhp......pGsIs.hpGhhLhhSHshMAVQAlhahPha..+hshhtlsVAhlWshhNDhIDYhahQ.hPhYsh...lppa..lhpIG..hho..................hhLSl.huLhlhh.hs.+..........................................	0	20	52	69
+7016	PF07188	KSHV_K8		Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein	Moxon SJ	anon	Pfam-B_16868 (release 10.0)	Family	This family consists of Kaposi's sarcoma-associated herpesvirus (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerises. K8 interacts and co-localises with human Pfam:PF04855, a cellular chromatin-remodelling factor, both in vivo and in vitro. K8 is thought to function as a transcriptional activator under specific conditions and its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5 [1]. 	25.00	25.00	440.70	60.80	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.69	0.70	-5.13	2	10	2009-01-15 18:05:59	2003-09-05 13:08:26	6	2	3	0	0	9	0	181.40	89	86.96	CHANGED	MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVK.................................................AEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ	.MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPP.PRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ.	0	0	0	0
+7017	PF07189	SF3b10		Splicing factor 3B subunit 10 (SF3b10)	Moxon SJ	anon	Pfam-B_16870 (release 10.0)	Family	This family consists of several eukaryotic splicing factor 3B subunit 10 (SF3b10) proteins. SF3b10 is a 10 kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a and a 12S RNA unit to form the  U2 small nuclear ribonucleoproteins complex. SF3b10 and SF3b14b are also thought to facilitate the interaction of U2 with the branch site [1].	18.50	18.50	20.10	20.70	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.50	0.72	-4.15	19	296	2009-01-15 18:05:59	2003-09-05 13:40:43	6	5	270	0	214	245	2	77.40	49	82.45	CHANGED	D+hphpsQLEpLQu+YlGoGHsDTT+.aEWhsNlpRDohuSalGH.shLsYhulu.cNEshu+lRhphL.........................p+MltPssss...Pt	.......D+hphpsQLE+LQuKYlGTGHAD.TTK.aEWhsN.+RDoauSahGH.slLsYhAlA...EN..E.u.huR.l.Raphh.........................cKMlpPsGsPP...............	0	75	116	176
+7018	PF07190	DUF1406		Protein of unknown function (DUF1406)	Moxon SJ	anon	Pfam-B_16883 (release 10.0)	Family	This family consists of several Orthopoxvirus proteins of around 185 resides in length. Members of this family seem to be exclusive to Vaccinia, Camelpox and Cowpox viruses. Some family members are annotated as being C8 proteins but their function is unknown.	20.20	20.20	20.40	20.50	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.40	0.71	-4.55	4	194	2009-01-15 18:05:59	2003-09-05 13:49:14	6	3	31	3	0	180	0	168.20	33	67.41	CHANGED	M.sI+hIshLhlIhs...lushp.ss.YpP............FNKLsIsL-IYsh-sl.ssYTssN......hl.hpchhIol.op.Csshhso.-l.sspDhp.lthhhhDp.phQpps+hCplshchpCph.pcP..lt..p....phShpu-.....hpChpslch.Ishlp....DpphL+.paTL+Iss...............thsl	......................................................P............FNhlsVclslYsV.N..sShTps.s.......sps.s.sIsTpEhTITl.pcs..CsPsFcs..sh.aolhsplshsuaFps-.sc.hQspsKhCTlshcl+Csp....psp.....s......lpphpt...c...spphs.puE.....GcCLsulcl.I.Y.N...Tssp.hc.p.p.l.........t.hhst.h...........	2	0	0	0
+7019	PF07191	zinc-ribbons_6	DUF1407;	zinc-ribbons	Moxon SJ	anon	Pfam-B_16889 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of around 70 residues in length. Members of this family have 8 highly conserved cysteine residues, which form two zinc ribbon domains.	25.00	25.00	25.00	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.94	0.72	-4.19	20	619	2012-10-03 10:42:43	2003-09-05 13:53:40	7	1	612	2	48	200	3	69.30	60	95.42	CHANGED	-hhCPsCpppL-hsu...tphHCspCppcaphpAhCP-CpppLEcLpACGAssYFCp.pCNpLhSKpRVcFphp	.............ElpCPpCpps.L-pss............spA+CsoCsc.....s.....hphpAlCPDC+QPLQVLKACGAVDYFCQ..pGHGLISKKRVcFVl.u....	0	8	17	32
+7020	PF07192	SNURF		SNURF/RPN4 protein	Moxon SJ	anon	Pfam-B_16890 (release 10.0)	Family	This family consists of several mammalian SNRPN upstream reading frame (SNURF) proteins. SNURF or RPF4 is a RING-finger protein and a coregulator of androgen receptor-dependent transcription. It has been suggested that  SNURF is involved in the regulation of processes required for late steps of spermatid maturation [1,2].	25.00	25.00	74.40	74.10	23.10	16.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.37	0.72	-4.12	2	30	2009-01-15 18:05:59	2003-09-05 14:02:14	6	1	21	0	11	31	0	67.40	87	89.83	CHANGED	MERuRDRLHLRRTTEQHVPElEVQVKRRRTASLsNQECHlY.RRSQQQQlPVVDFQAELhQAFLAETPRGG	.........RDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQ..QQVPVVDFQAELRQAFLAETPRGG	0	2	2	2
+7021	PF07193	DUF1408		Protein of unknown function (DUF1408)	Moxon SJ	anon	Pfam-B_16879 (release 10.0)	Family	This family consists of several hypothetical Lactococcus lactis and related phage proteins of around 75 residues in length. The function of this family is unknown.	21.50	21.50	21.90	144.50	19.70	20.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.57	0.72	-4.45	2	18	2009-01-15 18:05:59	2003-09-05 15:35:39	6	1	18	0	1	7	1	73.90	76	97.15	CHANGED	McTpIhNGRcVhhlPTslG.haaDL.KREshG.Vl.pTacR.DGohYhhpRp+scpE....KAAMLNpClSDWth	METTIINGRKVRllPTsVGQIYHDLIKRENRGVVVFETWcRPDGSLYMTSRKKNKQELAADKAAMLNECISDWKK	0	1	1	1
+7022	PF07194	P2		P2 response regulator binding domain	Finn RD	anon	Pfam-B_7970 (release 10.0)	Family	The response regulators for CheA bind to the P2 domain, which is found between Pfam:PF01627 and Pfam:PF02895 as either one or two copies.  Highly flexible linkers connect P2 to the  rest of CheA and impart remarkable mobility to the P2 domain. This feature is thought to enhance the inter CheA dimer phosphotransfer  reactions within the signalling complex, thereby amplifying the phosphorylation signal [1].	21.30	21.30	22.00	21.50	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.50	0.72	-4.13	80	704	2009-01-15 18:05:59	2003-09-08 09:47:26	6	18	549	1	219	650	12	84.00	26	13.32	CHANGED	psYplcVplscsshlKusRAahlhcsLc-hG.-llcohPshE-l.Es-p....F..cpphplhlloppst-clcphlt.sluEl......cpVplpphp	.......................haclplplpc.sshhKulRAhhlhcsLcc..hG.cll+ohP...s..hEcl..Es-p........F..tppFplhhho.p.p..s..t..-clcphl...pluEl......ccVplpp..s........................	0	88	155	181
+7023	PF07195	FliD_C		Flagellar hook-associated protein 2 C-terminus	Yeats C	anon	Yeats C	Family	The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria [2]. This alignment covers the C-terminal region of this family of proteins.	25.40	25.40	25.40	25.50	24.80	25.20	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.66	0.70	-5.07	35	2213	2009-09-13 17:36:45	2003-09-08 11:04:28	7	11	1857	0	507	1693	494	236.90	25	45.96	CHANGED	ApsAplslsG....h.slpssoN.plssslsGVolsL................ppsopssp.......slsl.spDssshppslpsFVcuYNplhsplsshos.....................t.tt.pppspsGsLtGDusl+slpspL+shhts....t.sss...........hpsLsclGIosspt.p...........GpLpl...DcsKLcpslp..pssssltph.....................................................................FsG.........................................ssGlspp..............lpstlpshs.....pss.Ghlp...................scpssLscphpplspphpshsc+hcshpp+hppp..Fsth-phhsphss	................................................................................................................................................ApsApls..l.sG...............l..pl.pp.soN..plsss...l.pG.l.T.lsL............................pp.s....s.ttst...........slsl...spDs.s....s.sppslpsaVs.uYNsLlsshsshop................................................t..pps..tpsGsL.hG.D.u.s.lps.l...p.splcshlss..........s.t..sss..................hpoLsplG.Iohsps...............................GpLp.l.....................Ds..sKLpp..A..Lp..p..s..s.su.ltph...........................................................................................................................................................................................................................................................................................................................................Fs.u.....................................................................................................................................p.sGl.ssp.......................ltshlss..hh......................sss...Gh..lp.....................................stps...u...lspplpplscphpshspp.hcsh.s+..hptp.....Fsth-shhsphp...........................................................................................................	0	175	326	420
+7024	PF07196	Flagellin_IN		Flagellin hook IN motif	Yeats C	anon	Yeats C	Motif	The function of this region is not clear, but it is found in many flagellar hook proteins, including FliD homologues ([1]). It is normally repeated, but is also apparently seen as a singleton. A conserved IN is seen at the centre of the motif. The diversity of these motifs makes it likely that some members of the family are not identified.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.66	0.72	-3.98	132	2915	2009-09-13 07:46:12	2003-09-08 15:29:45	8	27	1152	5	475	2258	345	56.80	25	13.44	CHANGED	slslphssttt..........lshsss..sshss.lsstIN...........sspsGVpAoh.......ssp.......upLsl...puss	..................................lslptssttts................l.shpss..sslts.l....sstIN............ss..ss.G.V.pAol.............sps..........upL.lput.......................	0	140	264	375
+7025	PF07197	DUF1409		Protein of unknown function (DUF1409)	Vella Briffa B	anon	Pfam-B_16557 (release 10.0)	Family	This family represents a short conserved region (approximately 50 residues long), sometimes repeated, within a number of hypothetical Oryza sativa proteins of unknown function.	21.10	21.10	21.20	21.20	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.47	0.72	-3.90	51	427	2009-01-15 18:05:59	2003-09-09 17:00:33	7	14	7	0	308	422	0	46.30	47	12.38	CHANGED	RLEsppl-.L........AcLcEh...pApls.Eh......tclhs.sthlE...pp+....hK.Lcp	..........................RLEApplD.L..........ApLc.Es.............pApls.Eh.....................tclhs.sthlEppp....h+Lcp.............	0	1	1	7
+7026	PF07198	DUF1410		Protein of unknown function (DUF1410)	Vella Briffa B, Bateman A	anon	Pfam-B_13132 (release 10.0)	Domain	This family represents a conserved domain approximately 100 residues long, multiple copies of which are found within hypothetical Ureaplasma parvum proteins of unknown function, as well as related species.	21.00	15.50	21.10	15.50	20.90	15.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.27	0.72	-3.66	67	980	2009-01-15 18:05:59	2003-09-09 17:11:28	6	16	37	0	55	835	4	68.20	20	15.61	CHANGED	spphtstplpl........phpDpsppphpl.....................phphsppppslt.....hssLpss.....p..p..Yplsclshsspphphs	...................................................hhNpplph........hhpDps.sppapl...............................pspl.spssphhh.....h..hss...Lsss.....p.....pYplsclhhsspp...................................	0	51	55	55
+7027	PF07199	DUF1411		Protein of unknown function (DUF1411)	Vella Briffa B	anon	Pfam-B_16764 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long that is sometimes repeated within some Babesia bovis proteins of unknown function.	20.70	20.70	20.90	21.20	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.10	0.71	-4.86	6	33	2009-01-15 18:05:59	2003-09-09 17:23:38	6	3	15	0	12	26	0	151.80	31	67.59	CHANGED	MSGHLVCKSGFGLGKVAKLMLASVVVLSAFSsNVWA.....scAEsspcPh.tph-GGhhot...............h--hpKL..pshsDlspT-NTEKTsLuDlSVKLGPhc+sM..hlKcVDVDMphLN+RIollLp+lTsaGP-SPsFGlSENIVKsLNK+GoIElPKcLAQpLCphcoGKhppYEWppFpDtFuoalA-hlss	.......................................h..............................................sp.s..tphpshh.oh...............h.pss...--hpKh..p.h..lpp.sc.T...EKo.l.h.lh.lp.ts.hcpshphplp.sssVp.h.hspccLoolLt.tlsphsPto.hhulScNllchLsKpp.p...-h.pclAptLsplcothhth.E..................h...................	0	12	12	12
+7028	PF07200	Mod_r		Modifier of rudimentary (Mod(r)) protein	Vella Briffa B, Wood V, Mistry J	anon	Pfam-B_16631 (release 10.0)	Domain	This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic [1], and both of these regions are represented in this family.  Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB).  The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37).  The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors [2].	27.00	27.00	27.00	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.97	0.71	-4.29	17	469	2009-01-15 18:05:59	2003-09-10 11:27:18	8	9	245	5	303	465	1	139.30	27	52.13	CHANGED	lpphShs-LpcLlpDc-thpc.hhtphsp..lpslppp+-phhspscpLAccNLthpspLcph+splp.pchppLpplppphpphhpchcch.upphSspslhphLQhsspcs-E-oEph..sccFLcGchsl-sFlppahphRphhHhR+hp.EKL	..................................pthohppLpclhp.sp...ph...lpp.hh...p....hsp....lpp.h....ptp..p-thls.sNcpL..A...............c..pNL..th.p..spLpp.hR...splp.pphpplpplppphpppp.p.ch..cc........h..pshosps.Lhth..LpststctEc.....-o-sh......s-pF..L.-...........G........c........h....s........l..p.sF.....lppa.phRphhHhR+.p.-+......................................	0	82	131	214
+7029	PF07201	HrpJ		HrpJ-like domain	Vella Briffa B, Moxon SJ, Bashton M, Bateman A	anon	Pfam-B_16649 & Pfam-B_11026(release 10.0) & Pfam-B_1285(release 5.4)	Domain	This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells [1].  This family also includes the InvE invasion protein from Salmonella.  This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive [2].  InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalisation of S. typhimurium into epithelial cells [2]. This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB [3]. SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system [4].	22.30	22.30	25.40	23.00	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.85	0.71	-4.23	36	767	2009-01-15 18:05:59	2003-09-10 11:43:52	6	4	513	10	60	405	7	160.10	23	46.32	CHANGED	s...........hhpphEctutsLspRch...........tptppppphpphhchl-ch.-tpt-p...phcpLpptLtt.....hssssplhshlpthhsDsucthlsL....pthlpp....ps.spthtptlppslppLpp..cputplpuGlNs...Ahtuttaut.tsstphptLRsLYppsl...tsp.tshsshhpslhppa	.......................................................tt.h.psh-chuhuLsphtt....................+tp.tcp.pphtpthp+llcpptps...........chcplhthh................tss.tph.s.hpthhs-suptllsL....pthLpp......cslpppl+cplpphLpcltt...pcshpl..Ghp......AlhutLhut...s......stshptLRphYcphl....psp.tshsphapclhsp..................	0	16	26	41
+7030	PF07202	Tcp10_C		T-complex protein 10 C-terminus	Vella Briffa B	anon	Pfam-B_13039 (release 10.0)	Family	This family represents the C-terminus (approximately 180 residues) of eukaryotic T-complex protein 10. The T-complex is involved in spermatogenesis in mice [1].	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.42	0.71	-4.73	8	224	2009-01-15 18:05:59	2003-09-10 11:56:30	8	9	126	0	134	206	9	150.70	39	21.12	CHANGED	KlEplhssGpRlIhFPNGT+KEISADGcoVpVpFFNGDIKcs.hs-tpVlYYYu-sQTTHTTYPDGLEVLpFPNsQpEK+asDGoKEIpFPDsTlKhLpscGp...EEslaPDGThlplp+sG-KhIpFsNGQ+EIHTspaKRREYPDGTVKTVYssGpQET+YosGRlRlKDc-GplIhDoc	..............................................................Ehh.htsGpp.lhasNGshKcl...t..s......Dt...ts.......shlpF.hNGDlKph..hs-...t.p.l..lYaYA..s.sp..ThHTTa..P.............-.Gl.EllpF.ss.sQ...........hE+..+aP.DG..p.....K.EIhFPDsol...K.l.scGp...E.EohaPDGTh.hphp.h..sGs.Khl..h.sN...G.p.c...El.+T.tt.hK.+............+ca.PDGThKhlas.s.GppEoph.sGph+hc...G............................................	0	63	74	99
+7031	PF07203	DUF1412		Protein of unknown function (DUF1412)	Moxon SJ	anon	Pfam-B_16907 (release 10.0)	Family	This family consists of several Caenorhabditis elegans proteins of around 70-75 residues in length. The function of this family is unknown.	25.00	25.00	25.80	34.00	20.80	16.00	hmmbuild  --amino -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.70	0.72	-4.05	7	36	2009-01-15 18:05:59	2003-09-10 12:39:10	6	1	5	0	36	28	0	51.90	69	68.96	CHANGED	GII.R-RR..psYassNGVVNNhVoDshhGGPTSLGWAQVPHlhSPMFSPVFG+	................GlI.RcRR..psYWhoNG.VV.NNhVSDNlsGGPTSLGWAQVPHhaSPMFSPVFGK..	0	9	17	36
+7032	PF07204	Orthoreo_P10		Orthoreovirus membrane fusion protein p10	Moxon SJ	anon	Pfam-B_16940 (release 10.0)	Family	This family consists of several Orthoreovirus membrane fusion protein p10 sequences.  p10 is thought to be a multifunctional protein that plays a key role in virus-host interaction [1]. 	21.20	21.20	21.30	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.43	0.72	-4.25	3	41	2009-01-15 18:05:59	2003-09-10 12:45:47	6	3	23	0	3	35	1	88.50	50	66.91	CHANGED	MhpMsSGSCNGATSVFGNVHCQAAQNTAGGDLQATSSlIAYWPYLAtGGGlIlIIII.luLlYCC+AKVKsDAsRSVF+RELlALoSGKsNAsPPuYD.V	..........................sGsCsGhsulFGsVHCQuupNoAGGDLQATSslhs.YWPYLAuG..G.GhlLIlIl.luLlYCC+uKhKscusRssa+RELVALopuphpshssshp.....................	0	1	1	3
+7033	PF07205	DUF1413		Domain of unknown function (DUF1413)	Moxon SJ, Bateman A	anon	Pfam-B_16942 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins which seem to be specific to firmicute species. Members of this family are typically around 100 residues in length. The function of this family is unknown.	25.00	25.00	25.10	26.30	23.70	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.09	0.72	-4.44	28	386	2009-11-04 10:27:19	2003-09-10 12:53:35	6	2	261	0	18	117	1	70.20	40	75.51	CHANGED	hccthptlcplsssssFph+..DLasc.......pWsphspsp+p.plG+hFhphVppsstht..h.hh.s+cssspphYpK	........h+ctlhtlps.sctosFsF+..DLFS+.......pWlshShA-RQ.cst+tFta.VKphscV...h.hs.ut.csu..thplYp............	0	8	13	18
+7034	PF07206	Baculo_LEF-10		Baculovirus late expression factor 10 (LEF-10)	Moxon SJ	anon	Pfam-B_16893 (release 10.0)	Family	This family consists of several Baculovirus specific late expression factor 10 (LEF-10) sequences. LEF-10 is thought to be a late expressed structural protein although its exact function is unknown [1].	19.70	19.70	28.70	62.20	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.35	0.72	-4.33	21	48	2009-01-15 18:05:59	2003-09-10 13:04:46	6	1	47	0	0	45	0	71.10	41	93.58	CHANGED	opsh.ts..DllssIL+cNLpLlDNsYlILNVlDpcss..p.......lcshClGEIsuhQs.cpssp.cuhSsoSsoSELpS	.....s..s..ts.sDllssILKcNLpLlsNsYIILNVlDpcss...p.........l+shClGEIsuhQT.csssp.-shSsSSsoSELpS...	0	0	0	0
+7035	PF07207	Lir1		Light regulated protein Lir1	Moxon SJ	anon	Pfam-B_16937 (release 10.0)	Family	This family consists of several plant specific light regulated Lir1 proteins.\	 Lir1 mRNA accumulates in the light, reaching maximum and minimum steady-state levels at the end of the light and dark period, respectively. Plants germinated in the dark have very low levels of lir1 mRNA, whereas plants germinated in continuous light express lir1 at an intermediate but constant level. It is thought that lir1 expression is controlled by light and a circadian clock.  The exact function of this family is unclear [1].	25.00	25.00	39.60	39.50	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.12	0.71	-3.96	5	52	2009-01-15 18:05:59	2003-09-10 13:11:41	6	1	31	0	16	46	0	122.90	41	93.23	CHANGED	MQsAuShslolsus.soosoupShshhhPpphps.pAsRpsphRl+Auuuuss.DsuTVDYsSsh.SVFPAEACDTlGGEACsu-MYPEVKLcs-ussss..sAsoEsVDREYLEY.s-PKTVFPAEACDDLGGEFC-P-	.........................................................s..p.....h.h............t.pthphts...u.s.sss-suTVDYs.Ssh.SVFPAEAC-slGGEACp.u.-MYPEsKLpspu.tsss......psssEsl-REYLpY.s-PKTVF.sEACDDLGG-FC-s.........	0	1	9	13
+7036	PF07208	DUF1414		Protein of unknown function (DUF1414)	Moxon SJ	anon	Pfam-B_16906 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.	25.00	25.00	48.30	47.80	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.81	0.72	-4.25	27	785	2009-01-15 18:05:59	2003-09-10 13:16:00	6	1	783	13	90	230	8	44.00	72	58.77	CHANGED	HcAPsDLSLMlLGNhlTNllsppV.sssQRtslA-pFucALtpSl	..HKAPTDLSLMVLGNMVTNLINTSl.APAQRQAIApSFAcALQSSI.	0	8	28	61
+7037	PF07209	DUF1415		Protein of unknown function (DUF1415)	Moxon SJ	anon	Pfam-B_16932 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	20.90	20.90	23.20	22.60	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.19	0.71	-4.53	56	495	2009-01-15 18:05:59	2003-09-10 13:18:37	7	3	477	0	142	398	77	170.90	45	88.00	CHANGED	pptlls.pTcpWlccsVlGLNLCPFA+p.ht+spIRasVo-AsshcslLpsLhpELphLttssst-l-.TTLllhPps..LpDFhDYpDhlDhA-sLLtphsh-GlhQlASFHP-YpFsGsssDDspNaTNRSPYPhLHLlREsSl-+AltsaP-.sEsIPERNIphhccLGt-....tappL	.........................p..tlltpTcpWLpcsVIGLNLCPFA+tshh.+....pp...........lRhhVS-Aps.-s...lLp..-LhpELptL.tt...ssspcl-.TTLllh.Pph....hpD.FhDYND.hl.-hA.-sll..pp..s..hEGl.....hQlAoFHP-YpFs...Go...-....sD.DhpNaTNRSPYPhLHLlRE-Sl-+Alps...a.P.D....s-sI.E+NIsplccLGt-thpp.h..................	0	41	83	116
+7038	PF07210	DUF1416		Protein of unknown function (DUF1416)	Moxon SJ	anon	Pfam-B_16939 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family appear to be Actinomycete specific. The function of this family is unknown.	22.10	22.10	22.10	22.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.84	0.72	-4.37	9	209	2012-10-02 19:08:27	2003-09-10 13:24:12	7	3	183	0	68	190	15	85.90	65	81.51	CHANGED	sulDltKEsVIpGpVh.psGpPVssAYVRLLDusGEFTAEVsoSAoGpFRFFAAPGoWTVRALsssusu.-tpVsAcsuslppV-lsV	.........AuVDlEKETVITG+Vl..suDGpsVGGAFVRLLDSosEF.TA.EVVASATGDFR....FFA.AP..GoWTLRALSsuGNG...Dus.VpPsGuGlHE.VDlpl........................	0	23	53	63
+7040	PF07212	Hyaluronidase_1	Hyaluronidase; 	Hyaluronidase protein (HylP)	Moxon SJ	anon	Pfam-B_16578 (release 10.0)	Family	This family consists of several phage associated hyaluronidase proteins (EC:3.2.1.35) which seem to be specific to Streptococcus pyogenes and Streptococcus pyogenes bacteriophages. The substrate of hyaluronidase is hyaluronic acid, a sugar polymer composed of alternating N-acetylglucosamine and glucuronic acid residues. Hyaluronic acid is found in the ground substance of human connective tissue and the vitreous of the eye and also is the sole component of the capsule of group A streptococci. The capsule has been shown to be an important virulence factor of this organism by virtue of its ability to resist phagocytosis. Production by S. pyogenes of both a hyaluronic acid capsule and hyaluronidase enzymatic activity capable of destroying the capsule is an interesting, yet-unexplained, phenomenon [1].	25.00	25.00	37.30	56.60	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.75	0.70	-5.40	2	54	2009-01-15 18:05:59	2003-09-10 13:38:03	6	2	22	8	6	52	2	239.80	70	77.07	CHANGED	NKPslsthApK.ETspKlpp....KADKpsVYhKAESK.ELDKKLsLpGGlhTGQL+hKPsuslthSSSTGGAlNIDhSpS+GAuhVhYoNpDToDGPLM.LRosK-TFsQSs.FVDY+GpTNAVNIsMRQPoTPNFSSALNITSuNEsGSAMQlRGsEcALGTLKITHENPSlcAsYDKNAAALSIDIVKK..osGtGTAAQGIYINSTSGTTGKLLRIRNhNcDKFYVpPDGGFauhtsS.lDGNLplKsPhuN-HAATKtYVDtcltcLKtLlstK	.......................................NKPslsuhApKpETssKIscL.S.KADKssVYhKAESKhELDKKLsLpGGlhTGQLpFKPN.SsIc.SSSsGGAINIDMSKScGAuhVhYoNpDToDGPLM.LRosK-TFsQSA.FVDYpGpTNAVNIsMRQPoTPNFSSALNITSuNEsGSAMQlRGlEKALGTLKITHENPslcApYDcNAAALSIDIVKK...psGpGTAAQGIYIN.STSG.TT.GKLLRIRNh.s-.DKFYVpsDGGFauttsSplDGNLplKsPTuscHAATKsYVDpclpcLKtLl.cK.............................	0	1	5	6
+7041	PF07213	DAP10		DAP10 membrane protein	Moxon SJ	anon	Pfam-B_16910 (release 10.0)	Family	This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells [1].	20.80	20.80	20.90	21.50	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.76	0.72	-4.23	3	40	2009-01-15 18:05:59	2003-09-10 13:48:29	6	2	25	0	16	39	0	71.20	48	94.25	CHANGED	MlPPGHILFLLLLPVAAAQTTPGSCSGCGPLSLPLLAGLVAADAVsSLLIVGVVFVCARLRSRPAQEDGKVYINMPGRG	...............M...GtlLhL.L.L...LsV...uA..sQ..............sos..............G..SCSGCGsLSLPlLAGLVAADAVhoLLIVssVFhCAR...RppPsp.ccs+VYlNMPsR...............	0	2	3	6
+7042	PF07214	DUF1418		Protein of unknown function (DUF1418)	Moxon SJ	anon	Pfam-B_16971 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 100 residues in length. Members of this family are often described as YbjC. In E. coli the ybjC gene is located downstream of nfsA (which encodes the major oxygen-insensitive nitroreductase). It is thought that nfsA and ybjC form an operon an its promoter is  a class I SoxS-dependent promoter [1]. The function of this family is unknown.	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.39	0.72	-4.36	7	515	2009-01-15 18:05:59	2003-09-10 13:56:04	7	1	507	0	26	140	0	94.00	67	98.88	CHANGED	MRolGsLP+sVLILEhLGMlLLslAhLSlNpYLoLPushuoPpAullMIFlGlsLMlPAAlslhWRlAphhuP.L.....hs+PPp.sp....otc-KpsDusH	.....MRuIGcL..PKuVLILEaIGMhLLAVAL.LS.ls-.L.SLPcPFupPp..............lt............ILMIFLGVLLMLPAAVlllhpVAKtLAPQL.....MsRPPphSc......S-REKcNDuNH................	0	1	5	16
+7043	PF07215	DUF1419		Protein of unknown function (DUF1419)	Moxon SJ	anon	Pfam-B_16972 (release 10.0)	Family	This family consists of several bacterial proteins of around 110 residues in length. Members of this family seem to be specific to Agrobacterium species and to Rhizobium loti. The function of this family is unknown.	21.60	21.60	21.70	22.30	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.60	0.72	-4.20	15	46	2009-01-15 18:05:59	2003-09-10 13:58:33	6	1	32	0	27	48	1	105.70	53	56.29	CHANGED	Ms..sPlRKVFpGVAcRcQMFRhFDRHuQRPsRacuDsusLYsGEWFEIspspHDYMhEILPPLWMRu-MFAMREFLTGslTSVFFsL+IDGRhRaFHGYCDLSD+sSPEcM	.................p..sshRKlapGVAsRpQMFchFDRHsQcPsphcsDsusLYsGEWFEIucspHDYMhEILPPLWhR....G....sMFAMREFLTGolTSVFFsLpI.DGphRaFHGYCDLuD+uSsEcM..............	0	2	15	20
+7044	PF07216	LcrG		LcrG protein	Moxon SJ	anon	Pfam-B_16974 (release 10.0)	Family	This family consists of several bacterial LcrG proteins. Yersiniae are equipped with the Yop virulon, an apparatus that allows extracellular bacteria to deliver toxic Yop proteins inside the host cell cytosol in order to sabotage the communication networks of the host cell or even to cause cell death. LcrG is a component of the Yop virulon involved in the regulation of secretion of the Yops [1].  	21.70	21.70	23.00	24.80	21.20	19.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.10	0.72	-3.96	4	75	2009-01-15 18:05:59	2003-09-10 14:19:17	7	1	70	0	9	31	0	95.30	52	99.54	CHANGED	MKps..s-aoc.....TlppAELAItDSDcRscLLpEMhtGLGluspAsplLFtu...ssE.hpsAEpELLsElpRpRppQPp.QshpG+RsRRPThMRGhlI	.....................MKss..s-asc.....TlcpAELAItDS-cR.ucLLpEMhtuL.GLsPpAsplLFuG..tssE..h+sAEcELL-El+RpRppQPQ...ps..tcG+RPRRPTMMRGhlI	0	1	3	4
+7045	PF07217	Het-C		Heterokaryon incompatibility protein Het-C	Moxon SJ	anon	Pfam-B_16951 (release 10.0)	Family	In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an individual colony to form a network. Hyphal fusion can occur also between different individuals to form a heterokaryon, in which genetically distinct nuclei occupy a common cytoplasm. However, heterokaryotic cells are viable only if the individuals involved have identical alleles at all het loci [1].  	20.60	20.60	21.60	21.40	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	606	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.11	0.70	-6.32	20	311	2009-01-15 18:05:59	2003-09-10 14:28:57	6	5	127	0	157	385	0	398.00	44	72.79	CHANGED	Mushh....ssLLlhhll.LllLPspstAFGAGNIASISpVEG+NWRHGDIEDhLtTlAhh+.......G+KaoshhVKRVYFGNWLRDYSQAlDVGTLK.uVsA-TIRILVWVLuFhoFGYATuEFEVTsERLGsYRPEEHIDNPKsYADspDARcYDsRLRGPVcp.tEL-IDPcTGMKNYIANE....sGGW.uTSAuYlRhohuRsIHaGRhYo.....cpGp-pDLpEALRhLGQuLHsLED.FuAHoNYsELALhEhGa+s......VFPHsGssTplpl.pG++..VYPLVTGTFGuVDFlHSVLGEAoDHhTQSElsEl-tALssAcssssss......................s.uslpuLLuKlP..........G.....sGDshsscA--LcppSpAQptpNpp..t............................................t.s...lsshpP-h.......ssh...cshtQIYPILEFRDclV+uIsshI...EKIPGLpsLlEpIoEsLTlFVhoLLAPFl+PIIsploppLpsGSSuVIsoStpcQaEsWssspCoDPTHSMLSKDHFSNlLNEPAG+VASsIlpYVVPRllhAW-ssslsscpVl--hLp.VFHHPAlRs.....psEh+RpMFcsVcpWhpspscctpc.LpchLSuEGV+sG+N+......psGspspuHupGpshshsts..s................uputsuuuhhpphppp	...........................................................................t................................................................................................a.......................................................................................................................................................................thcs..l.......................hthD..ouhKtYl.....t.........t.......h..TSsshl+h.ht+sIchGRhYs.....tpspctDLhEALRhLGpuLHsLE.D.FsAHSNYsELuLh-hGp+p.......VF.PHVGssTplpl......p.....G+p................VaP....LVTGTFGuVDFlHSVhGE..hsD+h...o.....QsElpphp.tl.tupt.tt..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	47	88	130
+7046	PF07218	RAP1		Rhoptry-associated protein 1 (RAP-1)	Moxon SJ	anon	Pfam-B_16981 (release 10.0)	Family	This family consists of several rhoptry-associated protein 1 (RAP-1) sequences which appear to be specific to Plasmodium falciparum [1].	20.50	20.50	251.30	106.30	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	782	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.51	0.70	-6.44	2	109	2009-01-15 18:05:59	2003-09-10 14:37:53	6	2	16	0	7	110	1	637.70	65	99.73	CHANGED	M.hhluSLlllFasLapNVusGIslNG-pphspph.sp-FN.DDhN.Wh.lsctpFLNoapcphSs.SFlEsKuSh-sG.......SpsscuSppGpG+...............DShsDhpFhss.s.s.KsupPpuspspu.tSSSsupopuSu.SssKSuS.aGtSs.S-.SshcSuptSu.....VGucE.t...........pEhY......FshpashpphpcphsILKN-hshVtpcEth.hDEphcchcpc+Kcth.KhhtEuD.E..hhsEp.pFlcpphp-ppltGuFocFhSpLNPFKK-.h..KpElShhTa..Is.plssKE..h+sLGlutpYp.Y.pohLYsCPNss.hFDohEsLptcl.c.+c+Euhhsphh-ppKECLKNhGlhDhELsDspsKhGssIGShGEhHlRLYEhENDLhKapPslDYhTLADsYKL.KNcl.pLppVNFCLLNPKTLE-FLKKKEIh-LM.G-D.ItYcEpFspaMp.SIsCHlESLIY-Dl-uSQDhthVLK.sKSKLallpsGLoYKu+KLl.KlasEIQKNP-.laEKLTWIY-NhYhlKR.aThhAhcsVC.pYlpHs..phYTpLp.hhshIl-.sRhYuuCFKNlhlYNAlISGIHEphKphhKLhPRpshL.DhHFpulhcKE.K..KhhpTsalh..aDPoVtuYAhhpl-RhsMVolINsaFEAKKKtLohhlupMKhDhholpNE-.KIPNDKuANSKLss+LhphaKAEI+caFKEMR.pYshLIphRY+uHhKKNYhhaKRL-	.............................SLlllFasLapNVusGIslNG-pphupph.sp-FNhDDhN.Wh.lsccpFLNoapcphSs.SFLEsKSSh-sG.......SssscuSppGpG+...............DS+sDhpFhAsss.s.KTSpPpuspsuu.+SSSsup...o+uSS.SN........s....KSuS.aGcSspS-.SshcSuppSu.....VGucE.s...........cEhYs.....FsYKashsphpcpIsILKNEhshVtpcEth.hDEphcchcpc+Kcth.Khht-oD..E..hhsEp..pFlcpphp-ppltGuFocFhSpLNPFKK-.h..KpElShhTa..Is.plspKE..h+sLGluhpYp.Y.pohLYsCPNss.hFDohEsLptcl.c.cc+Euhhsphh-p.pKECLKNhGlhDhELsDspsKhGssIGShGEaHlRLYEhENDLhKapPslDYlTLADsYKL.KNcl.pLppVNFCLLNPKTLE-FLKKKEIh-LM.G-D.ItYcEpFspaMp.SIsCHlES...LIY-Dl-u..........SQDht...h....V...L.K.sKSKLallpsGLoYKu+KLl.KlasEIQKNP-.laEKLTWIY-NhYhlKR.YThaAhcsVC.pYlpHs..phYopLp.hhshIl-.sRhYuuCFKNlhlYNAlISGIHEphKphhKLhPRpshL.DhHFpulhcKE.K..KhhpTsalh..aDPoVtuYAhhpL-RhsMVolINsaFEAKKKtLohhlupMKhDhhSLpNE-.KIPNDKuANSKLss+LhphaKAEI+caFKEMR.pYshLIphRY+uHhKKNYhhaKRL.....	0	1	2	5
+7047	PF07219	HemY_N		HemY protein N-terminus	Vella Briffa B	anon	Pfam-B_16745 (release 10.0)	Family	This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis [1].	28.20	28.20	28.80	30.00	27.00	26.60	hmmbuild  --amino -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.08	0.72	-4.50	19	1471	2012-10-11 20:01:00	2003-09-10 15:05:05	8	28	1455	0	312	955	302	108.30	35	26.03	CHANGED	GhVhIphsuhph-sSlhtslhhllhhhsslhl.......lhhllpplhpsstpsptahcpp+RcRuppulppGlhshupGchstAc+hht+u.uch..s-pssLthLhuApAAptpGc	...............GYVlIp.hss.a.pI..Es.Slssh.llhlllshlllah.......l.hll+plhpsss+spsa.assRKc+RAcpthppuLlcLuEGDa....ppuEKhhs+...s...Acp.............u-p...P.........slshL.lAAcAApppGD......................................	0	64	156	231
+7048	PF07220	DUF1420		Protein of unknown function (DUF1420)	Moxon SJ	anon	Pfam-B_17056 (release 10.0)	Family	This family consists of several hypothetical putative lipoproteins which seem to be found specifically in the bacterium Leptospira interrogans. Members of this family are typically around 670 resides in length and their function is unknown.	18.10	18.10	18.40	18.40	17.80	17.30	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.19	0.70	-6.16	2	13	2012-10-03 03:08:05	2003-09-10 15:58:07	6	1	9	0	3	11	68	573.50	57	99.04	CHANGED	MKFGLDANlsYPPLSVlYSIhLIhGCDFLGFYILKLFEspLGclKNTWhRWQAPLhGALLLSV.LYPLAL.uhTsRhhMcSsAhhLslLGhhNlshFlKphppNhs.lsh.p.Nl.+Slpap..h-h....cp.K+sF.LFK.hh.hhsKFsLIshNchLNlFIhLLhluYGhLALCPlTNADSLDYHIGVAIEILNQGKMPsF.GWFHGRLAGSGEVLNALGLAIGAEQFGSLLQFsGLLuIYGILuFYSFhEK..tsDG.VWRcIIIIAFLSSPVLVFLVSSsKPQLLQlGMTSFAlsLLLEIhSKhKTDKNKL.hF.LICILIMSsTQAKFSFFLSAFLIGLhSlh.LGSIRLahYGlLIulFFhlLI.FPulFWKIKNasSohIDsllhPLPG.saPGVppFEssLRNYpDSsL.FPLSLlhPNpFGVlTTlIG.GLFLlIFVKPIss.psFlLShhIIlFVILG.LhGQpASRFFLEPFlWhLISLIslsshth.Nl+Fs+psluhhllLQAshThsIl.lGIYQLhPGVFSIp.REKVMsQYuNGYsLMKWsG.sLPK-AVLLSQHRSlALSERKTLSLDWh.FVsFsShlASPYL+pIKDENVTHILhhG-hSKsoPF.GCIGNsIGKTKSp.shRNPhs.pDaFTsILsEFp.spLsQCuN.lL	..........................MKFGLDANlsYPPLSVlYSIhLIhGCDFLGFYILKLFEspLGclKNTWhRWQAPLlGALLLSVlLYPLAL.uhTsRhhM+SsAhhLslLGhANIshFlKphppNhsSlsYhp..Nlh+SlpapS.h-h....cp.K+sF.LFK.hh.hhsKFsLIspNchLNlFIhLLhluYGhLALCPITNADSLDYHIGVAIEILNQGKMPsF.GWFHGRLAGSGEVLNALGLAIGAEQFGSLLQFsGLLuIYGILuFYSFAEKF.psDG.VWRcIIIIAFLSSPVLVFLVSSPKPQLLQlGMTSFAlsLLLEIFSKhKTDKNKLhhFS.LICILIMSsTQAKFSFFLSAFLIGLhSlhpLGSIRLFFYGlLIulFFFlLI.FPulFWKIKNasSoaIDsllpPLPG.saPGVppFEssLRNYpDSsL.FPLSLlaPNpFGVlTTlIG.GLFLlIFVK.PIVsp+sFlLSlhIIlFVILG.LhGQKASRFFLEPFlWhLISLIsLsShup.Nl+Fs+psluhhllLQAshThsII.lGIYQLFPGVFSIplREKVMSQYANGYoLMKWsGhsLPK-A.VLLSQHRSIALSERKTLSLDWh..FVDFsStlASPYLKpIKDENVTHILhaG-TSKsoPFpGCIGNsIG..KTKSppVsRNPFN+pDaFTsILsEFp.DpLPQCuN.lL................	2	1	2	2
+7049	PF07221	GlcNAc_2-epim		N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	Vella Briffa B	anon	Pfam-B_17012 (release 10.0)	Family	This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.	19.90	9.10	19.90	9.10	19.80	9.00	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.40	0.70	-5.43	20	1825	2012-10-03 02:33:51	2003-09-10 16:14:30	6	21	1288	23	552	1700	239	297.20	21	69.11	CHANGED	Gh.Fp...p.LctcGpshsssc..tchhspsRplasFAhAtt.h.G.hsG.hh.s.h...ssHGlcaLppshR..DsppG...Gaahsl..s.ssu.s.hDssccsYsaA...FllhAhus.A...htuGts...cA..cshh...s....cshsll......-p+hhctctsh.ht-phstsashh...........G....pNsp..MHhhEAh.LAhh-sos..-tp..aL........spAtplschhhpchhs.....tsshhlhEaFchpWss..shst-...t.hcshhhpPGHthEWuhLl....lp....l.t......ttptsschl.spAcpLattulspuhshctu.GlsYh.hshpupsss....ps+h..hWspsEsltAA...stLtpt.oG-..pc...YhphhpphhshhtpahhD..t.hGtWacplstcsp..lspsl.uuposhYHhhsA	..................................................................................................................h.at.h.hs.t.p.G.p..h.t...t....thhhpsR..............lasau...huht.....h........s......p...st....hh...p..h...............scp.uh.c....hh.p.t.t.h.t.....Dt..phG..............G..a..a.htl..............s.stt...s......hc...t.......p.....+..p......hY.....sps..............F.....s...lh..uhup...s..........h.t.s.G.p.s....ps..p..ph..h...p...pshphl...................pchh.hs...t.t...t....s.h...hh.pp.h.s.t.shp..............................ps........................tN.s.t.....M.Hhh..E.uh...l.....h....h.h.c....s..pt.............-tt.......ah............................pph...pl....hph...hh....p.phhp...........ttp.h...h.l..Ehh....t..........ps...thp.............................s..h............hp..P........G.H.h...E...huhLh..........hp....ht.....................t.tt.....thh....tt....A.......t.l.......h....t...h...s..h...p...t...u..h..........s....p........t...u...Gh....h....hh....h..s.h...p...s.p..shs...................pp+h....hWs.s....Esh..hsh.............h.h..h...h....ph........o...uc........tp.............h..ph.hpph...hp.a.hh.p.ah..h...........D....p............G.t.W.a.t...l...stpsp...st.t...t.........s...............................................................................................................................	0	172	349	448
+7050	PF07222	PBP_sp32		Proacrosin binding protein sp32	Moxon SJ	anon	Pfam-B_17278 (release 10.0)	Family	This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix [1]. 	20.70	20.70	98.50	21.10	18.80	19.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.79	0.70	-5.19	3	56	2009-01-15 18:05:59	2003-09-10 16:20:49	7	3	28	0	25	44	0	194.90	54	48.61	CHANGED	Mh+sAAGFLLMLLcVLLLPLoPsoAE-STPASTPGSPLSsTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSNLPYASWFESFCQFA+YRCSNHVYYAKRVhCSQPVSILSPNTLKElEuSAEVsPTTMToPIusHsTlTE+QoFQPWPERLsNNVEELLQSSLSLGGp-Qssu...t+PKQEQhlp++QE.lQEHKpEEuQcQEEQEEEE..cEEEAKQEEGQGT--	.........................................p.Asu.l..LLcVLLLshs.PssAp-o...u.sTPGSPLSsoEYERFFuLLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSsLPYASWFESFCQFsQYRCSNHlYYAKR..VhCSQ..PlSlLSPsoLKE....l-sssEVs.soo.hT.sP.hss+hpsTE.pQs.psWs-RLpsNlc...cLLpuuhSLsGpcp..t..........tpc.....+tQt.http..pttp..p-Qtc.............................................................	0	1	1	11
+7051	PF07223	DUF1421		Protein of unknown function (DUF1421)	Vella Briffa B	anon	Pfam-B_17006 (release 10.0)	Family	This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.	29.00	29.00	29.30	29.30	26.90	28.40	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.77	0.70	-4.67	9	104	2009-12-15 14:25:35	2003-09-10 16:29:41	6	4	24	0	56	102	0	285.30	31	67.71	CHANGED	L+EVQsuVQlL+DKQEIsETQhpLuKLQls+tp..ppscspu.ps-sptpsssP..ht.p..t.hP..phshAhP......u.........lPss.us.Ps.p.psQ..........Psp.Qh..........................................................P.phPsp.lp.....s.P...........ttpPaasPP...u.QsptsPsQQ.....hp..PP.........................Q.tPsPtsPppppY....QsPPQhsQhpQ..............sPsPQ...hP.sssh.Pc....PY....tuhPPs...Psshs.p.P.usssP...hasss...sthYsssuuhPso.s..pt..PPP..t...............YshSGsPsp.u........usssatPptsup...utusuY...PphssAp....LPQuhshuSuP.shtt.....SspShpptPlsDll-KVsoMGFsRDQVcuslp+lTEsGQsVDhNslL	............lpEVptuVQlLpDKQElsEsphpLuKLQhsptp...pptp..ts.......h.p..ss.s..............h.........s.h.s...........s..............ss.........sp...................................t.p...........................................................s.p.s........................................hhs.s....t..p.......ssQQ......p...s..............t..t.s.P....s..pph...........Q..s..sQ.......Q......................pss...p...h...ss..............P.......Pa......s.sss......s.s.........s.s...s.....h..t.s.........h.ts.....sh.................sst....t................s........................a..su....s......s....s.......................hts.t.st.....shtss.Y....sp...ssAp....hPpt.....ssss.................ustshpphshs-hl-KlssMGas+-pV.puslp+hsEsGQslDhNslL..........	0	8	34	46
+7052	PF07224	Chlorophyllase		Chlorophyllase	Moxon SJ	anon	Pfam-B_17130 (release 10.0)	Family	This family consists of several plant specific Chlorophyllase proteins (EC:3.1.1.14). Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyses the hydrolysis of ester bond to yield chlorophyllide and phytol [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.96	0.70	-5.63	4	48	2012-10-03 11:45:05	2003-09-10 16:40:43	6	3	28	0	29	968	169	233.40	35	75.56	CHANGED	sSssohssFpcGpapssplsl-............ssp.ssssPPKPLlIsoPsEtGsYPVlLFlHGhhLpNp.YSplhsHIASHGFIVVAPQLaplhP...PuspsElcsAApVhsWhs.sLpthLP...ssVpuNlphhAlsGHSRGGKTAFAlAL...Gau.....plpFSAlIGlDPVAGTuKsppTsPplLTYcPsSFsLs.IPVsVIGoGLG..thsshhssCAPsslNHcEFapECK.uspuHFVAsDYGHMDMLDDsh.uhhuh.huthhCKNGpc.+ssMRRhlGGIVVAFLpsahcsDsp-hhtIlts.ShuPhpL..usEhcsssshh	.................................................................h......ssFp.G.ht..sp.hplt.............................ss...sP+......sL..h.l...h..sP...s..........t..G...s..a..PV.llFhH......G......h....h.....l.......h....N.....p......a.....Y...s.....p....l...ht....H....l...u.S.......H.G...aI.l..l...A........P.........Q........l....h........p....h....hs..................s...s..s................p.......-.....l.....c.........t........s...u..............p...........l......h...........s..........W......l.....s.....t......s..........L....t...t........h..L.P..........................t...V..p....s......s........l...p..+........l...slsGHS+GG.+.sA.F..A.lA...L.......shu....................plp.h...u...s..L.l.G.lD..P....V....sG.....hs.K.....t...p.h......P.l.......L.s....h...sp.SF..sh..s....hP........s.hV..I..GoG..L..G..........h....s.s.......CAP...tthNH..tpFa.cCp....st.a...Fl.stcYGHhDhLDD.....s.....h.u.....hhC.p..p.u.p..t...+p.MRchsuGlhVuFLps.h..sp....t.th..Ih....t........................th.....................................................................................................................................................................	0	4	20	26
+7053	PF07225	NDUF_B4	NDUFB4; 	NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)	Moxon SJ	anon	Pfam-B_17132 (release 10.0)	Family	This family consists of several NADH-ubiquinone oxidoreductase B15 subunit proteins (EC:1.6.5.3). 	20.70	20.70	20.90	21.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.49	0.71	-4.32	10	149	2009-01-15 18:05:59	2003-09-10 16:45:59	7	1	114	0	79	140	1	106.10	34	93.10	CHANGED	cYKsuPLuoLPpTLDPsEY.slSPEpRRApsERLAlRApLKRcYLLQhNDP+....R+ulIED.......PALsRWsaARshNlYPsFRPTPKTSLLGllaGhGPLlFWYaVFKTDRD++-chIpcG+L....DRsFslSh	...................................a.thS.-tpch..pRhthRspL+ppYhhphssPp.....ct..ull..D.......PALhRa.aAps.h.shY.pFRPTP...Ksu.hlG.h.h.h.uls.Pl..hhhhhshKo-RDtpcp.hppGph...c...........................................................	0	20	32	55
+7054	PF07226	DUF1422		Protein of unknown function (DUF1422)	Moxon SJ	anon	Pfam-B_17087 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	20.80	20.80	20.80	23.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.37	0.71	-4.36	14	660	2009-01-15 18:05:59	2003-09-10 16:54:00	6	2	654	0	56	195	3	115.90	70	97.14	CHANGED	Mspps.....ppE+tTLlLALlAGLshNushusLhoS.VsFSlFPlIALVLulYsLaQcYLppshspshPhlusAsFhlGlhhYSAllRApYPplGSNFhPhllulsLlFWIGhKLthhpppt	.........M..KQu.sQD+GTLLLALlAGLSINGTFA...ALFSSIV.PFSVFPlISLVLTVYCLHQRYLNRTMPVGLPGLAAACFILGVLLYSTVVRAEY.PDIGSNFFPAVLSVIhVFWIGtKhRNRKQ.-s................	0	3	15	34
+7055	PF07227	DUF1423		Protein of unknown function (DUF1423)	Vella Briffa B	anon	Pfam-B_17028 (release 10.0)	Family	This family represents a conserved region approximately 500 residues long within a number of Arabidopsis thaliana proteins of unknown function.	25.20	25.20	25.40	25.40	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.80	0.70	-5.82	10	189	2009-01-15 18:05:59	2003-09-10 16:56:15	6	7	34	0	96	177	0	301.30	29	51.54	CHANGED	AREpV-llA-+M+chP-EaLEcLKpsLRuILEG..sup++-EhhhLQ+hVQoRSDLTscTLs+AHRVQLEILVAI+TGIQsFLHsslolSQssLlEIFLYKRCRNIACpStLPAD-CcCcICoN+cGFCsLCMClICsKFDFuVNTCRWIGCDlCSHWTHTDCAIR-u.IssGsSsK.uusGsuEMhF+CpACs+TSELhGWVKDVFQpCAPsWctEoLl+ELDaVs+IF+uSEDsRG+pLFhKs-ELl-KLKuplA-s.sAs+hILtFFQEl-.Duu+ShEss.-suRhI..APQ-As..N+IApVVpEulcpMphVu-EKhRhhKKARhul-sC-+ELc-KA+clupLchERp+KK.QlDELEoIVRLKQAEA-MFQLKAsEAR+EAERLpRIslAKo-KsEEEYASpYLKh+LsEAEAEKpaLaEKIKhQpcSp+s.pu.....GcssphhMhSKI+-LL	.........................................................h......................................................................................................C+Nh..sCps..l.sspth.Cp.lCsppsuFCptChCslC.p+.F.D.sh.s.....ssp.WlsC........D........h......CuHhsHs-CAl+cthht.G.shp....ushu......h-h.FpChuCs+so-l...h.G.aVKclhphs.t.shph-sLh+cLphsp+lhpuScc.+...u+pLh.hscphht+Lc.st............................................................................................................................................................................................................................................................................................................................................................................................................................	0	14	63	81
+7056	PF07228	SpoIIE		Stage II sporulation protein E (SpoIIE)	Vella Briffa B	anon	Pfam-B_17063 (release 10.0)	Family	This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.18	0.71	-4.60	173	6344	2012-10-03 01:39:20	2003-09-11 09:29:08	7	400	2137	23	2480	8434	1928	192.30	20	35.38	CHANGED	sssphslsluDVhG....+GlsA..Ahhhshlpssl+shs.tpshs..............................Pspllpclsphl.tphpss........................hasTshhsh........h-.tstplphssAGHss.sllhps.ts........sshhhh.tssGhs..lGl.ss..................hshpstphpLtsGshLllaTDGlh..........Est.....shssth....phl..phhtt............spphsctlhpplhp.....................hs..phpDDhsllll+hp	.................................................................................................................................................................t..sphtlsluD.sh....G.........+G...l...s..A....A..h.h.h.....s..h...l.....p........s....h.....h.....c...s..h....s...p..p..s..hs...............................................................................ssp.ll...p.p....l.s.......ph.l.......t.p.hpps..................................................................hh..s.T...h..hhsh......................h-........p....s........t.......p........l....p..h.....s..s.AG.H..ss..s.h.l..h.cs...t............................ps.h.hh.h....t.s....s..u...hs...........l.G..l.....ss.....................................................hph..p..p..t...p....h...p....l...p..s...G....-.......h.l..llhTDGlh.........................................Esh.................s.ptp.h....h..t...p..phh..................phltt...............t.s......spp..h..hpt.l.h.ptltp.........................................htt.t...t.hpDDhsllhhch.t.....................................................................................................................	0	977	1887	2293
+7057	PF07229	VirE2		VirE2	Moxon SJ	anon	Pfam-B_17380 (release 10.0)	Family	This family consists of several VirE2 proteins which seem to be specific to Agrobacterium tumefaciens and Rhizobium etli. VirE2 is known to interact, via its C terminus, with VirD4. Agrobacterium tumefaciens transfers oncogenic DNA and effector proteins to plant cells during the course of infection. Substrate translocation across the bacterial cell envelope is mediated by a type IV secretion (TFS) system composed of the VirB proteins, as well as VirD4, a member of a large family of inner membrane proteins implicated in the coupling of DNA transfer intermediates to the secretion machine. VirE2 is therefore thought to be a protein substrate of a type IV secretion system which is recruited to a member of the coupling protein superfamily [1]. 	25.00	25.00	35.30	34.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.89	0.70	-6.11	4	10	2009-01-15 18:05:59	2003-09-11 09:47:11	7	1	7	1	4	10	0	533.60	58	97.82	CHANGED	MDPpupssutN.s.ph.tshtsts.ss.Ktp++cslsSoohs-IpMTsupEThE....GoPs+T-sluspLDt-.lDSpSStsSuSscGNQuElppELSuLFupMs.LPGpDRRsDEYILVRQTGpDtFsGTsKGsL-HLPTKAEFNAuCRLYRDGAGNYYPPPLAF-RIsVPspLpspht.hEs+-psK.pFQYKL-VWN+AHAEMGITGTcIFYQTDKNIKLD+NYKLRPEDRYlQT.+YGRRElQKRYpHpFQAGSLLPDIhIKTPcNDlHFVYR.AGDpYANKpFpEFE+hIKp+YGS-TEIKLKSKSGIMHDSKYLESWERGSADIRFAEFAGENRAHN+phPtATVNMGpQPDGQGGhTRDRaVSV-aLhQshPNSPWuQALK+GELWDRVQlLARDGNRYhoPpRLEYSDPEHFsplMsRVGLPtSMGRQSaAsSlKFEpFssQAAVIVAsGspLRDI+DLSsEcL.QQloppcVLlADRNEpGQRTGTYTSlsEYcRLhh+LPsDAApLLuEPsD+YSRDFVRP-Psh.PIsDSR..RsYEsRsRuQoVNuL	...............................................................................................MDPpu.ssucNls.stttshpsss.scsKRpK+cslsSoThsDIpMTsupEThE...pGSPT+TEslus+LDts.lDSpSStsSuSsHGNQuElppELSuLFuNMu.LPGpDRRsDEYILVRQTGQDtFsGTsKGNL-HLPTKAEFNAuCRLYRDGAGNYYPPPLAF-+IsVPtQLpspht.hEsKEpsK.RFQYKL-VWN+AHAEMGITGTcIFYQTDKNIKLDRNYKLRPEDRYlQTEKYGRREIQKRYcHpFQAGSLLPDILIKTPcNDIHFVYRFAGDsYANKpFpEFE+sIKp+YGS-TEIKLKSKSGIMHDSKYLESWE.RGSADIRFAEFAGENRAHN+QFPsATVNMGpQPDGQGGhTRDRHVSVDaLhQsAPNSPWuQALK+GELWD....RVQlLARDGNRYhSPsRLEYSDPEHFTpLMNRVGLPsSMGRQSHAsSlKFEpFDuQAAVIVAsGPsLRDI+DLSsEKL.QQLop....KDVLlADRNEKGQRTGTYTSVAEYERLhh+LPsDAApLLuEPoDKYSRDFVRPEPAh.PISDSR..RsYESRPRuQoVNSL........................................................................	0	1	3	3
+7058	PF07230	Peptidase_S80	Phage_T4_Gp20;	Bacteriophage T4-like capsid assembly protein (Gp20)	Moxon SJ	anon	Pfam-B_17388 (release 10.0)	Family	This family consists of several bacteriophage T4-like capsid assembly (or portal) proteins. The exact mechanism by which the double-stranded (ds) DNA bacteriophages incorporate the portal protein at a unique vertex of the icosahedral capsid is unknown. In phage T4, there is evidence that this vertex, constituted by 12 subunits of gp20, acts as an initiator for the assembly of the major capsid protein and the scaffolding proteins into a prolate icosahedron of precise dimensions. The regulation of portal protein gene expression is an important regulator of prohead assembly in bacteriophage T4 [1]. This family represents the protease responsible for the proteolysis of head proteins, a critical step in the morphogenesis of many tailed phages, Cleavage facilitates the conversion of the prohead to the mature capsid. All these cleavages are carried out by action at consensus S/A/G-X-E recognition sequences at 39 cleavage sites. Evidence of multiple processing sites in nine phiKZ proteins appears to represent a built-in mechanism by which the phage ensures that the majority of the propeptide regions are removed, and emphasizes the essential nature of processing in phiKZ-head morphogenesis [2]. The family is classified by MEROPS as a serine peptidase.	25.00	25.00	49.00	48.90	18.50	17.60	hmmbuild  -o /dev/null HMM SEED	501	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.58	0.70	-6.18	11	1179	2009-01-15 18:05:59	2003-09-11 09:57:38	6	2	283	0	0	965	2471	203.10	65	98.50	CHANGED	M........lcLFuhhhc.-p.phpcchpscstShssPcssDGAp-lps......uuasuhh.ph.Gs...thpspp-LIppYRplstpPEVDsAls-IVNEAIV.-.tsccsVpl-L.ssochSpslKc+IpEEFccll.clLsF-++upchFR+WYVDuRIaaHKlIDhcpPpcGItELRhlDPpplchlREhhpp..s..sGsplh+uhc.............EaalYssps.phs...hsuth.tuss.tl..KIs+DAIsYuHSGLhD..tscphlluYLH+AIKPsNQL+MlEDAhVIYRloRAPERRlFYIDVGNhPppKApQYlpsVMpphKN+lVYDusTGclKNpppthSMhEDYWL.RR-GtpsTEVoTLPGuQshG-h-DVcYFp+KLYcALplPhSRhss-s..uGhslGt.usEITRDEL+FoKFltpLpp+FpplFpD.LKTpLILKsIIT.-EW--.t-pIphsFppDsYFsElK-hEILppRlNhlspl-P..alGKYaSp-Ylh+cIL+hTD--Icp.ccQIEpE	..........................................................................................................................................................................................................................................................................................................................................................................................................................NLPKsKAEQYLRDVMsRYRNKLVYDAsTGE...lR.DD+KaMoMLEDFWLPRR.EGGRGTEIoTLPGGQNLGElsDl-YFpKKLY+uLNVP.SRl-s..-s...G..F.N..L.GR.S..oEIhRDElKFsKFVuRLRKRFSplFsDhLKTQLlLKsllT.sEDW-p.M.p.-.HIQYDFlhDNaFsELKEsElhsERLshlst.........................................................	0	0	0	0
+7059	PF07231	Hs1pro-1_N	Nematode_res_N; 	Hs1pro-1 N-terminus	Vella Briffa B	anon	Pfam-B_17124 (release 10.0)	Family	This family represents the N-terminus (approximately 180 residues) of plant Hs1pro-1, which is believed to confer resistance to nematodes [1].	25.00	25.00	105.10	104.40	22.10	21.20	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.27	0.71	-4.69	5	36	2009-01-15 18:05:59	2003-09-11 10:30:34	7	2	19	0	22	37	0	176.50	48	40.19	CHANGED	MVDLDWKpKMVsS..DhPsKSPKLShpc.....slSlPp.hplPslSo-ISsAAPulCSAYEhYLRLPELRpLWSSp-FPpWsNEPILKPALQALEITFRFISsVLSDsRPYINRREWNRRLESLsTcQIEIIAsLCEDEEp...hRGouPsAsLSuG......................s.o.sppaSEhSLLPRLATWpKSE-VAQRILhoVE	..........................................................................hss.sl.p..ssssshstAYE.YLRLPELppLWpupsFPsWssEsllKPALQALEITFRhlSsVLSDPRPYhsRREWsRRLESLAspQlEllAhLCEs--p.....ttpAPhAcLSuu......................s.shspphSEsSLLPRLAoWpKScslAp+IhauIE.	0	8	16	19
+7060	PF07232	DUF1424		Putative rep protein (DUF1424)	Moxon SJ, Bateman A	anon	Pfam-B_17284 (release 10.0)	Family	This family consists of several archaeal proteins of around 320 residues in length. Members of this family seem to be found exclusively in Halobacterium and Haloferax species. The function of this family is unknown. This protein is probably a rep protein due to conservation of functional motifs.	20.20	20.20	23.00	22.10	17.70	16.90	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.03	0.70	-5.68	2	13	2012-10-02 18:54:06	2003-09-11 10:49:46	6	1	10	0	1	12	0	291.40	36	69.10	CHANGED	MApps....G.+LRcElThDTSRuV+AsShupAl-pFpuWYsDQRsTQhVVEpt.hGEpVGFchPNRFTPEYREMLYAKAQSLERGLREcWGsLLHTuMVTLTASoT---Gt.RP.l-HhcDLLpSWpAVhcALt+sLEsREaEYLAIlEPpp......uGYsHIHLGVFV+GPVVAEQFpsVLDAHl+Ns.sAGc-AHp.Vh--stDEsAVplRRSu+PsRpsGlENLGAYLAAYMAGEYGsEs.tMPtpVRAFYAsMWAoGpQWFRPSNGAQchMQPEp.D-t-SlEEWEMVGIAPEGDLtD.IIEVDPppPRsDPYRRLRTPPPGG	............................................................t.+AsoWucAlspFpsaasDtRssphshEsp..G....-psuhphP..sRFsP-YpchhYAKupuLER....GL....R..cc.......aG....phL......HTuMVTLTASSssps..G+.tPPl-H.......hc-Llc..SWcA......VR+AL.tRV......L-......u+......EW-YhsIhEPHp................uGYsHlHlGVaVcGs.....V.....VAEpFpPVlDuHVcNC.sAGc-AHp.h..h--..sts-csVpV+Rsup.sts..sGVE.......NLGuYLAAYMAG.YssEshEhPhphpAahAshWAouRQhhc.SsuApEhMps-.............................................................t..............	0	0	0	1
+7061	PF07233	DUF1425		Protein of unknown function (DUF1425)	Moxon SJ	anon	Pfam-B_17314 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 125 residues in length. Several members of this family are described as putative lipoproteins and are often known as YcfL. The function of this family is unknown.	25.70	25.70	25.70	26.80	24.40	25.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.96	0.72	-4.42	37	877	2009-01-15 18:05:59	2003-09-11 10:56:45	7	1	872	2	101	375	20	92.40	42	74.46	CHANGED	lhhssssLusplslsslpssps.sshhpussplpsphpsshplpYRFhWYDspGhplpsp.ssW+slhlpGppphplpulAssspAsca+lhl+p	.....................l.Vh-solLuAGlosEpPslo.sS..DhpssAoupL.h...NcppcPls.VpYRFYWYDscGL....E..h....+...P.L........E.t...sR.o..lsIPAcssVoLhusAshhsA+csRLYLa.L.	0	11	35	69
+7062	PF07234	DUF1426		Protein of unknown function (DUF1426)	Moxon SJ	anon	Pfam-B_17431 (release 10.0)	Family	This family consists of several Banana bunchy top virus proteins of around 120 residues in length. Swiss:Q9IGU4 is annotated a movement protein whereas most other family members are hypothetical. The function of this family is unknown.	25.00	25.00	189.00	188.90	20.20	19.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.56	0.71	-4.36	3	31	2009-01-15 18:05:59	2003-09-11 11:09:30	6	1	3	0	0	31	0	116.50	82	98.88	CHANGED	MALTTERVKLFFEWFLFFGAIFIAITILYILLVLLFEVPKYIKpLVRYLVEYLTRRRVWMQRTQLTEATGDuElsRulVEDRRDQQPuVlPasP+VIPP.QsR...R-DQAhRusAGPMF	MALTTERVKLFFEWFLFhuAIFIAITILYILLVLLFEVPKYIKpLVRYLVEYLTRRRVWMQRTQLoEATGDVElGRGIVEDRRDQQPAVIPpuSQV.PS.QsR...RDDQGRRGNsGPMF.....	0	0	0	0
+7063	PF07235	DUF1427		Protein of unknown function (DUF1427)	Moxon SJ	anon	Pfam-B_17474 (release 10.0)	Family	This family consists of several bacterial proteins of around 100 residues in length. The function of this family is unknown.	21.10	21.10	21.10	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.17	0.72	-3.91	32	341	2009-01-15 18:05:59	2003-09-11 11:15:13	6	2	240	0	124	290	13	72.20	43	92.05	CHANGED	KsYllSLuAGlLVGllYuLlsVRSPAPPlIALVGLLGhLsGEQllPls+phlsutthtst.httth..ph........ttttt.............ttppp.s	.....h.YllSLusGlLVGllYullpV+SPAPPll.A.LlGLLGhLlGEQllPhs+phhtt....................................t...........................	0	19	46	82
+7064	PF07236	Phytoreo_S7		Phytoreovirus S7 protein	Moxon SJ	anon	Pfam-B_17475 (release 10.0)	Family	This family consists of several Phytoreovirus S7 proteins which are thought to be viral core proteins [1].	19.80	19.80	20.30	20.80	17.10	19.70	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.56	0.70	-6.18	4	20	2009-01-15 18:05:59	2003-09-11 11:20:55	6	2	11	1	0	21	3	470.80	42	87.70	CHANGED	hsAIVCluLLoE+sVLoRsLsDpsKcFYpulpGphh.tscsl..Tc+huppSl.lR+lVPosTlILDaKsEsFI+pN.shSL.DIsGSPSNTAPKTsFpSIMPSLSsLFssPFlQGAFRHslISoh.GptTsLLILVVGPPSGF.cp.sVuSuuSsV-ssoNAcIDLsclVulNosMhppTpLVSAuulpAMulsDVhl+CsSLDplLlshAlKYF+sYVsshpsuuhspATpIhLNosFcELFslpsscpthlts-shtsspsphRGlVLPhGHGp..ssLpp+HP-lFI-.-ulFoc-E+ucLsch+hp..-sDsaEE...hFsphVpKalppGcYGN+VIluH+sspLsssGlpIlGhaplss.pslcpplp...ShKsclDhs+pNWctlpspshVsssTlppLHctIL.Dhhssospull.ss...uscspEtIslpFhNGFPpcKaullpLEKsGIpVVu..phsDss.lVlsNsPshVSRutKuptp......psRu+hDAtplslDTDclSpsphIphl+oh	.........MoAIVsVsLLSEpsVLsRsLsDhVKshYptlpGssssst-sI..pt+hospol.lp+hlPhsTVhl-ahDpcaIptNPshShM-IlGSsuNTAPKTTFQSlhPSLSALFGVsFIQGAFhHpVISop.GsphShLlLVlGPPusFh+psSVuuuSSlVpV-SsucIDLsDsVtINuhMlpsTKLVSASulpAhuls-V..KCsSLDshlIhpAlpYF+pYs.ttphGohDsATplhLNhPhcElFSsc..oupuc.Lpsc..sa+-.scupltGlVLPsGHGK..oTLsScYP-lFlplpt.hsc-cppth.....s...suDshEp...happhIp.pplscGcYus+V.lLucssccL.ssGl+llGsa+lss...spVccpls...shKschDphcpsWcshSG.shVoscslshLHDKlL.DllospsKulhhscp..........ph+scppIslhFKNGFP.t+aShspLpKpGIsVVp..-Ls-ss.lllsNtPppssRps.tpsK......sphpphcus.+VslDTDslop-phIsKlKs.L........................................	2	0	0	0
+7065	PF07237	DUF1428		Protein of unknown function (DUF1428)	Moxon SJ	anon	Pfam-B_17402 (release 10.0)	Family	This family consists of several hypothetical bacterial and one archaeal sequence of around 120 residues in length. The function of this family is unknown.	21.00	21.00	21.20	21.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.23	0.72	-4.12	72	547	2009-01-15 18:05:59	2003-09-11 11:24:00	6	3	516	2	124	281	36	102.90	66	86.44	CHANGED	sYlDGFVlAVPsuN+-sYpchAppAutla+.EaGAlchVEsWGD................DVPpG.........clTsF.pAVpscssEsVVFSWlhWPsKtsRDsuhp+hM....sDPRhps..s..sMP.FDGK	...pYVDGFVVAVPA-KKDAYREMAuKA.APLFK.EFGAL..RlV..ECWAs................DVPDG.........KVT.DFRMAVKAEEsEpVVFSWIEYPSKEVRDAANpK....MM....u.DPRMKE..hG-..sMP..FDGK.............	0	37	76	97
+7066	PF07238	PilZ		PilZ domain	Bateman A, Galperin M	anon	Pfam-B_17421 (release 10.0)	Domain	PilZ is a c-di-GMP binding domain [3] which is found C terminal to Pfam:PF07317.  Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias [5].  This domain forms a beta barrel structure.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.29	0.72	-4.00	191	5848	2009-01-15 18:05:59	2003-09-11 11:30:13	9	113	1860	15	1946	4774	350	102.40	16	32.82	CHANGED	ppRpt..........Rhphphss..................hhttsspth.........p.....sthhDlShuGh..tlph.....tp..thphsp...........l........plph.thsstth................................htupVhphptp..............thGl...pF.......ths.pptppltphlht	................................................................hRp........R.ht.ht.h.s......................................hhht.s.s..phh..............................p..........spl....hDlS.tuGh..tlth....sp..........thphGp..............tl............plpl....phsptsh.............................................h.........htu.pl..h...phptp........................tlGl..pF.......ths...t..t..l.th...h..............................................................	0	680	1242	1622
+7067	PF07239	OpcA		Outer membrane protein OpcA	Moxon SJ	anon	Pfam-B_17433 (release 10.0)	Family	This family consists of several Neisseria species specific OpcA outer membrane proteins. Opc (formerly called 5C) is one of the major outer membrane proteins and has been shown to play an important role in meningococcal adhesion and invasion of both epithelial and endothelial cells [1].	25.00	25.00	25.20	25.00	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.73	0.70	-5.46	2	56	2012-10-03 17:14:37	2003-09-11 11:44:44	6	1	36	2	2	42	0	202.30	53	89.45	CHANGED	QELQTANEFTVHTDLSSISSTRAFLKEKHKAAKHISVRADIPFDANQGIRLEAGFGRoKKNIINLETDENKLGKTKNVKLPTGVPENRIDLYTGYTYTQTLSDSLNFRVGAGLGhpSSKDSIKTTKHTLHSSRQSWLAKVHADLLSQLGNGWYINPWSEVKFDLNSRYKLNTGVTNLKKDINQKTNGWGFGLGANIGKKLGESASIEAGPFYKQRTYKESGEFSVTTKSGDVSLTIPKTSIREY	.....................................................sEaTV+TDlSp.o.ppA.LKEKHKstKpIuhRADhPFD.hppGhRhEsuauRsKKshhslpp.spp.hG........psV.EpRhDlYsGYTYTQsLS-uhphRsGhGLGaEp.KDu.ltspKtT.l.....popRpuahsKsHADLhSpLGsGWYlNPWuEVKhDLsu+hKhNssVsslppDINtK.TpGWGhGlGANIGKpLs-SsuIEAGPFYKpRsaKcSGEF.slst.................................	0	1	1	1
+7068	PF07240	Turandot		Stress-inducible humoral factor Turandot	Moxon SJ	anon	Pfam-B_17438 (release 10.0)	Family	This family consists of several Drosophila species specific Turandot proteins. The Turandot A (TotA) gene encodes a humoral factor, which is secreted from the fat body and accumulates in the body fluids. TotA is strongly induced upon bacterial challenge, as well as by other types of stress such as high temperature, mechanical pressure, dehydration, UV irradiation, and oxidative agents. It is also up-regulated during metamorphosis and at high age. Flies that over-express TotA show prolonged survival and retain normal activity at otherwise lethal temperatures. Although TotA is only induced by severe stress, it responds to a much wider range of stimuli than heat shock genes such as hsp70 or immune genes such as Cecropin A1 [1].	20.70	20.70	24.50	52.70	20.60	17.90	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.88	0.72	-4.49	9	49	2009-01-15 18:05:59	2003-09-11 11:50:11	6	1	7	0	12	57	0	82.40	32	60.05	CHANGED	susDcsoKh+sh.pLlshYc+assph.LsspcRtphcchlpcacscp....hVDGVPuQGGhhstlhttll..hu.tlssuhhcthhE	...usD-sTKhcsl.cLlshYc+assph.Lssp-+ppl-chlpcaccpp....lVDGVPuQGGhhtplltphls.suptlssshhp.....................	0	8	8	12
+7070	PF07242	DUF1430		Protein of unknown function (DUF1430)	Vella Briffa B	anon	Pfam-B_17033 (release 10.0)	Family	This family represents the C-terminus (approximately 120 residues) of a number of hypothetical bacterial proteins of unknown function. These are possibly membrane proteins involved in immunity.	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.35	0.72	-3.94	19	961	2012-10-03 05:18:07	2003-09-11 13:29:22	6	2	507	0	38	409	3	99.70	36	16.07	CHANGED	Ilhlhhs..lhlhhphshhYFcpa++clhIK+laGhshhcpappalhhplhshlhshshhhlhpp..s.llhhhslllhlhphllhlhhp.+hpp+thhpll.KG	.................Ilsluou..ILLF.ohNhLYFEpFRRplhIKRluGhphhEhHtp..YL...luQhulh.lh.Ghllohllp+......-hh.luhLslhlFhhpuLLpLhhQ.pKEp+hshtllKG.................	0	13	21	31
+7071	PF07243	Phlebovirus_G1		Phlebovirus glycoprotein G1	Moxon SJ	anon	Pfam-B_17508 (release 10.0)	Family	This family consists of several Phlebovirus glycoprotein G1 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi [1].	25.00	25.00	44.80	44.00	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.14	0.70	-6.35	4	348	2009-01-15 18:05:59	2003-09-11 13:41:35	6	4	57	0	0	288	0	338.10	54	53.03	CHANGED	sHlpNRPGpGtat..hssp-DusC+.lsYGssCpuFDahLchs+aPFFpSahcH+ohLEAhtDsI.Itppss.oCsl..sot+sstCh+EtthhKt+CPsshsusaYlsspGclssVKCcpNhELoEDCs.CRphptpu......pKh.hPLQDhhCQpsps-hossKphhKGlCcIGlhshKcCc.phoosaEsVsFhlhKs+tKlYl-phcl+sc-slpp-sFlCY....th.ss-ssuss+ttLKpVcVspCKtVssSpsKhCoGDpsFCS+YsCpsphs-saC.hAsGSGslplplsGVWlpPhClGYERVlVcREh.ts..s.pcsCDTCloEChcptllV+STGFcIouAVACSHGuChSspQpPSTplhlPYPGhupSlGGDIGlHhoH-ssssSsHhVsHCPP+DsChsHuCllCsHGllNYQCHTsLSAhllshllh.hlhhhLhllppsLhll+lhPthLlsPlsWlshFhtWhh+ph+h+stssIsRlNccIGWh-puths.pcscchp++..tPhsR.psshLhlL.LlhossS	.............................................................................................................................................................................MASVKCP.P.K.YELTEDCNFCRQMTGAS.....LKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGT..M.D..S..GQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECT....AQ.spshC.hhptsu.l.lphsGhhhhPhChGapchhsphp..t...pp.t.CssChhcC..ttlhlhohs.cl..AssCupt.C......................................................................................................................................................................................................................................	0	0	0	0
+7072	PF07244	Surf_Ag_VNR		Surface antigen variable number repeat	Yeats C, Fenech M	anon	Yeats C	Family	This family is found primarily in bacterial surface antigens, normally as variable number repeats at the N-terminus. The C-terminus of these proteins is normally represented by Pfam:PF01103. The alignment centres on a -GY- or -GF- motif. Some members of this family are found in the mitochondria. It is predicted to have a mixed alpha/beta secondary structure.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.81	0.72	-3.56	395	14038	2012-10-01 23:48:22	2003-09-11 13:48:50	10	36	2604	32	3439	10633	6054	78.00	20	34.08	CHANGED	hhlp..plph.p.G.........t..........p.thpsp...tlp....p..h.....p.....h....ptG.............shasppplpp....shppLp.......spGa.....hspV.......ps..psp....pt....tt.......h..slshplpEs	................................................hlpplph..p..G..........s........................p.th.psp........hlp.........p..l....t..............l...........ctG......................................................chasp.pp.lsp...........shc.pLp..........spGa..............h.s.sV..........ps....php.......s..............sp............l..slhhplpEt..................................	0	1092	2111	2811
+7073	PF07245	Phlebovirus_G2		Phlebovirus glycoprotein G2	Moxon SJ	anon	Pfam-B_17508 (release 10.0)	Family	This family consists of several Phlebovirus glycoprotein G2 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi [1].	25.00	25.00	27.30	25.60	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.62	0.70	-6.23	4	259	2009-01-15 18:05:59	2003-09-11 13:53:40	6	21	64	0	61	265	0	373.20	38	33.86	CHANGED	CS-pllAsSKlspCsscGSsThCplSGTlhl+AGsIGuEoClhLKGsc-sppKFloIKTISSELsCREGpSaWTo.YsPpCLSSRRCHLVGEChus+C.pW+sspsStEFoGlscsplMpEN+CFEQCGGlGCGCFNVNPSCLaVHuhL+Ss++EAl+VFsClDWsHRlsLElTsasGchphVsLsu.oTpFhsWGSloLuLDuEGIoGTNSaSFlcSuuGuFAllDEsaS..PRcGFLGEIRCsSEuuAloAHcSClhAPsLIcYKPMhDplECTTsLIDPFAlF.RGSLPQTRNGpTFouSh-K+TVQAFTsGtV+AsloLshDsaEVsF.sptssCsAoFlNlTGCYSCstGARVClplpustssshascscDpSlsllhslpssspD.CpVLHFopP.Vc.-hhYSCsup.+shlIKGTLlAhsPaDDR++pGGsSsVVNPKsGsWsh.sWhSGLhsWLGGPLKThLhILGalALuIlhhllllllstpuVsph...slKKKs	.........................................................................CSE.l...AsS+lhpCsp.....pGsp..s..pCphoGosll+hGslGuEuCL.h.lKG....p....-s.p.pp..h......lpIK.TlSSE..L..sC+EGpSaWTspasspChSoRRC+hh...G-Chss+C.papsNphS.sEashhtcs.pshttstCh-pCGGhuC.G.CFsssPSCLFh+tahpssp...tphhclapC.sW..s.....phh..l..p..l...T......s.....t...p...ht.......h.....h.....h..s.ssp......hphs.o.l...s.l........s....t.l.....s.s.....ssh.s...hp................t.........th.....ulhsts.s........sh.GhlG.ElpCsocpssh..p..sCh.hs.slhthp..hsth...C...s...phhs..shh...h.s..t..lP.th..h..ss..h.p..attphtppsh...psh.s.st.lpsthpl..h.c.s.hpl.h.t...pCput.h.h.ploGCYSC.tGup...h...phphpu..pt..p..s...h...h..pt.ttph.........s..ssps.........h.h..s..s.....lp.ph.hsCs.t...p..h.lpG.L...h..t................t.....p.................s..t.htth...h..t...........h.h....lh...h.hhhh..................................................................................................................................	0	3	13	61
+7074	PF07246	Phlebovirus_NSM		Phlebovirus nonstructural protein NS-M	Moxon SJ	anon	Pfam-B_17508 (release 10.0)	Family	This family consists of several Phlebovirus nonstructural NS-M proteins which represent the N-terminal region of the M polyprotein precursor. The function of this family is unknown.	23.90	23.90	24.00	30.70	22.50	23.80	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.72	0.70	-5.23	3	151	2009-01-15 18:05:59	2003-09-11 13:59:48	6	2	22	0	0	160	1	102.90	40	14.73	CHANGED	IasLLsVL.TlulLVsuslpLcophSSSRs-TCFSsoTsPEhIEtYWth-StKc-.MPph-L+CRhs.-uDhKhhop.shIStI+EVpTSssEL+hSCGsps+SLGtlITsDGLNN.hhGshIIsCsTs.a.psIssG.t.sRl..DapplKppA...-EK-thIph.+TK-sE-.....D.+sQlhhpEIpQlKNplpK+RN-....lhRGQE+RDAKplscEoMARlusL+pc.h.LT..........DElpphKsphp.hRp+.h..pTVlPA.........LhosALLS..suPlsA	..............................................................................................................................................................................................................................................................................................................................................................................................................................hpshss......................................	0	0	0	0
+7075	PF07247	AATase		Alcohol acetyltransferase	Vella Briffa B	anon	Pfam-B_17349 (release 10.0)	Family	This family contains a number of alcohol acetyltransferase (EC:2.3.1.84) enzymes approximately 500 residues long found in both bacteria and metazoa. These catalyse the esterification of isoamyl alcohol by acetyl coenzyme A [1].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.56	0.70	-5.95	9	349	2012-10-02 12:01:53	2003-09-11 14:19:53	7	8	173	0	229	370	1	388.30	14	80.46	CHANGED	+hGhlEpYahtcstpphaoNFsVhuphNptls+p...LshALRplll+pshLspslh.th..p..thhsussahspP.........l.cplchsDVl.................catc.s.phsshh.phlsphhhshssss.PhW+Llllsstpst.....ppal.alssHshhDGlSuspFacDLhcpLsphcsssh..................-hlhcY.....scDhs....KLPtPIpptl-h..hsshhslshhhhss.lhpth.hpch..............ppshhsshsssptutpshp.hlphossclppI+spsKpp...csTlTsalpusahluLtch.h.......shhp.sphshchtlPhssR+alP-ctE...papYGshVuuspa..hIpshshppsp.pph.......WsLsphappplspuhpstcphpshGs...ph.llchhNlcchhpsch.ppp..RusshlSNlGhhs......pssptaplpDhhFuQssu.ht.sFsLsVlSTssGGhNhslohhccs.pppsp.......ccFhshhcphl	.............................................................................................................................................................................................................h..sht.hh.p....h................................................l....lphpt...hl.....................................t........t............t.........h...p...h...p...t...h.........h.....h.................p....P.W+.lhl..l...pt..............................h.l..hhhpHshhDGhSuhhFacshh.ptLp.t.h.pt............................p......lhp...................ts...................l....P.....s..hp.hhth...........hh........h.............hh...p.....h......h...htp........................................sh...h....tht..h..t......s...p..s.hhh.h..l...pls..s...p..p..hpplhpts+pp....tsTlTuhlpuhhhhultp...........hhtt.tt.h.t...hpht....h.shsh.Rpa..h..sp.t............t...................h.s.s..hl........s..t.....p......h............h......th.p..h..................pth.............................Wphspphp.p.plp..p..t.h.p.p..t.......t....hh..............l.....h.p..h.h..s..h............t.hh..t.ph.....t.p.......ttsh.lSNl.Ghhp.................................ttt.h............ltph.hFsps.......ht...h..hshh.s.h..t.h.h.hs................................h............................................................................................................................................................................	0	50	118	198
+7076	PF07248	DUF1431		Protein of unknown function (DUF1431)	Vella Briffa B	anon	Pfam-B_17470 (release 10.0)	Family	This family contains a number of Drosophila melanogaster proteins of unknown function. These contain several conserved cysteine residues.	21.10	21.10	21.20	21.20	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.00	0.71	-11.84	0.71	-4.25	17	156	2009-01-15 18:05:59	2003-09-11 14:24:22	7	2	17	0	90	156	0	139.20	29	58.24	CHANGED	Cpps..Cst.h..phDhpaY+PSDKttRcYQpTWsEC...s.hhhK.K+lCt.t.hhsPphtRRptptpstss..t...............s.h.ph....tt.CP+lphP.sC+suRtPPpCchs.Rt.osC.pKhps.YPSFSECp+ttlsphs..PhECpCLctsshCphapth++p	...............................................C.....h..phD.haY+sSDKttRcYQpTWsEC....s.hh..h+.KchCs.tthh....s.h...RRp..t..p.h.tss.....................t....h.........pt.Cs.+.hths.sC+su.+hsspCphh.+t.sp.C.pKhts.aPSFSECp+..h....h...shECtChp.hs.shCphht.ht.........................................	0	15	16	57
+7077	PF07249	Cerato-platanin		Cerato-platanin	Vella Briffa B	anon	Pfam-B_17594 (release 10.0)	Family	This family contains a number of fungal cerato-platanin phytotoxic proteins approximately 150 residues long. Cerato-platanin contains four cysteine residues that form two disulphide bonds [1].	21.30	21.30	21.50	21.30	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.53	0.71	-4.10	5	199	2012-10-01 21:39:58	2003-09-11 16:37:23	7	4	96	2	128	194	0	112.80	36	70.21	CHANGED	lSVSYDsGYDDAsRSMssVSCSDGsNGLlTKY.WPTQGuVPGFPRIGGlsuIAGWNSPsCGTCaKlTY.NGNTIaVlAIDuAuuGFNIupoAMscLTNGpAspLGRVD.AsYpQVusSsC..Gl	......................................ploYDssYD.su...st.SlssVuCScGsNGL..hs+h..apT.........GplPsF.......PhIGGs....slsGW.N..S.s.s..CG.s..CacloY.....s......G.....c..oIhllAlDp.........u.s.u.....G...FNl...uhsAhstL.TsG.p.....A.....s.....p.....h.....Gp..ls......sshppVssopCu............................	0	40	73	109
+7078	PF07250	Glyoxal_oxid_N		Glyoxal oxidase N-terminus	Vella Briffa B	anon	Pfam-B_17519 (release 10.0)	Family	This family represents the N-terminus (approximately 300 residues) of a number of plant and fungal glyoxal oxidase enzymes. Glyoxal oxidase catalyses the oxidation of aldehydes to carboxylic acids, coupled with reduction of dioxygen to hydrogen peroxide. It is an essential component of the extracellular lignin degradation pathways of the wood-rot fungus Phanerochaete chrysosporium [1].	24.30	24.30	24.30	24.30	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.93	0.70	-5.30	8	414	2009-09-11 10:08:30	2003-09-11 16:40:41	6	32	162	0	296	444	14	222.20	27	32.88	CHANGED	MHhtLl.+ss+VlhaDRTsaGsSpluLPsGt.CR.ssPp.DtstKhDC.oAHSlLaDVsTNslRPLslpTDTWCSSGulpssGoLV.......QTGG.t-...G-+slRhFoPCs....ssoCDWlEhsss..Lus+RWYuTNpILPDG+hIllGGRc..........sFNYEFaPc.sp.sspsssl.FLt-TcD.spENNLYPFVaLLPD...GNLFIFANsRSIlaDacpN..pVVKEaPpIPGG.sR..NYPSoGSSlLLPL.....hpssslssEVLVCGG	.............................................................................................................................................hh.u..as........s.s.th.c....s...l.t....l...h....o.ssaCuuG.s.hl.s.s..G.phl............................psG....G.......t.s......................Gt.p.s.l...R.h....hs.P..ss........t.ss..s.WhE.sst............Lpps..RWYsosthLs.D..G.p.l.lllG.....Gpp.................................sss..h.E.hh.Pp........t......sst...s..hth....h..ht...h....pc......st..........tNLYPalalLPs...GplF.....lhus....p....p.uhlh.D.tst....ph.hpp..hP...s...lP.......u......s...s......R...sYP.sGuushLPl.............s..t.....splllCGG.............................................................	0	131	220	266
+7080	PF07252	DUF1433		Protein of unknown function (DUF1433)	Vella Briffa B	anon	Pfam-B_17690 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	25.70	25.70	25.90	25.90	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.17	0.72	-3.78	17	1163	2009-01-15 18:05:59	2003-09-11 17:04:15	6	2	257	1	16	477	0	88.50	47	68.38	CHANGED	aacpQcpRIslYlKYNlpc...hKSlpFTphcpoPMGs.hIcGYINssKchcFpAhIustcs...pFpsshshstE.Ls+LlK..c..tK...SVsEI..Kc	...................YaccQpcRIsLYhK.a.Nhpc...hKol..+F.T.s.h.c.puPMGu.hsIcGYINcN.K.c.cFsAahsspcN..aQF.ss.sl.h.hocc..LucLlK...cp...hK....Ss--I.Kcc...............................	0	5	6	13
+7081	PF07253	Gypsy		Gypsy protein	Moxon SJ	anon	Pfam-B_17444 (release 10.0)	Family	This family consists of several Gypsy/Env proteins from Drosophila and Ceratitis fruit fly species. Gypsy is an endogenous retrovirus of Drosophila melanogaster. Phylogenetic studies suggest that occasional horizontal transfer events of gypsy occur between Drosophila species.  Gypsy possesses infective properties associated with the products of the envelope gene that might be at the origin of these interspecies transfers [1]. This family contains many members with full-length matches; however, it also includes a number of very short sequences and short matches of sequences with other unrelated domains on them, which cannot be excluded. These matches may represent remnants of once-functional genes.	20.30	20.30	20.70	20.50	19.20	20.00	hmmbuild  -o /dev/null HMM SEED	472	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.66	0.70	-6.17	4	136	2009-11-18 11:40:33	2003-09-12 09:50:16	6	8	26	0	22	137	1	259.90	27	82.28	CHANGED	s+ITDaS+ANYIPVhDGcVLVa-ppshl+HSuNlSEYtshID.ET-plp-SF.PpSHM+KLLpVDssHLRshLslLplHH..RlARSLDFLGTALKVVAGTPDssDh.+I+hTEspLV-uNspQIhINocTQpQIN+LTDTINKllpupKuD.lDTsHLaEsL.sRNRllspEIQNLhLTITLAKhsIVNPsILDHsDLcollcp....sTPI...hpllEsucI+VLQSpNhIHhlItaP+lphpC.pKVslhsVsHpcTlLRLc-sslAECc+-hauVps.CohTs+sTFCcpu.....pp-oCsppLHAGssApCH.sQsSHL+tIp.VD-GlllIN-tsApVpsDsssclhlpGTaLITF.pcSATINtopFhNhcpslsKtPGllpSPlLNI.u+c.lLSlPhLHRhs.pNLhpI+shpc-Vsutt.sphhhshGsllssGlhhuhslhLshRt++uotphp+slcphs.sE-GppLctGlVpN	....................................................................................................................................................................................................................................................................................................................................................................................................................htu..upCp..h..tp....h..lptu.hh.hhst..h.h...tt..p..ltGoallpa.ppph.lstp.a.s...............................sh..lp..p.t.................................................................................................................................	0	0	0	14
+7082	PF07254	DUF1434		Protein of unknown function (DUF1434)	Moxon SJ	anon	Pfam-B_17586 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 135 residues in length. Members of this family all appear to be Enterobacterial proteins. The function of this family is unknown.	20.70	20.70	21.10	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.78	0.71	-4.34	9	557	2009-01-15 18:05:59	2003-09-12 09:52:45	7	2	555	0	49	179	2	124.40	72	96.04	CHANGED	MsLWpsDLRVSWRoQhhSLLlHGllshllLLsPWP...u.YsslWLlLLoLVVF-ClRSQRRIpupQGElpLLsDspLpWptpEWpIl+pPWhl+.GhlLpLppsss.p+Rp+LWLAADSMspsEWRcLRpLLL....pp	..................MVLWQSDLRVSWRAQWlSLLIH.G.L.V.AA.V..I..LLMPW.P....LS..YT..PLWM.l....L...LSLVVFD....CVRSQ.R.R....I.N..uRQGEI+LLMD...GRLRW..Q.G...QE.......WoIVK...sPW.hlKSGMhLRLR.s-u.G.........+.........R......Q....HLWLAADSMDEAEWR-LRRILLQQ........	2	4	14	30
+7083	PF07255	Benyvirus_14KDa		Benyvirus 14KDa protein	Moxon SJ	anon	Pfam-B_17595 (release 10.0)	Family	This family consists of several Benyvirus specific 14KDa proteins of around 125 residues in length. Members of this family contain 9 conserved cysteine residues. The function of this family is unknown.	29.30	29.30	30.10	213.00	27.00	29.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.80	0.71	-4.25	2	7	2009-01-15 18:05:59	2003-09-12 09:58:37	6	1	3	0	0	7	0	122.60	80	96.84	CHANGED	MthssSlsVaVtcsIT......psschFSlKhupWpLFTstVaVpYRths-cEpslKDssRLHFphpCVpCspKlphKtpN+sH.calppGalRhsRNFSIlGsCucC...h-Shs.tDEhcpslV	MGMVDSLCVFVGRVITEGSESVEGVERFSIKFSEWKLFTTAVYVEYRQLGEKECSLKDVGRLHFNMSCVKCCpKLKCKKQNKNHSKHVQNGYLRKVRNFSILGVCGDC...CESFTLADEKHHVIV	0	0	0	0
+7084	PF07256	DUF1435		Protein of unknown function (DUF1435)	Moxon SJ	anon	Pfam-B_17631 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.	22.10	22.10	22.40	24.10	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.58	0.72	-4.00	7	529	2009-01-15 18:05:59	2003-09-12 10:16:13	7	1	520	0	37	208	0	77.10	68	86.83	CHANGED	MLpRsLuSGWGVLLPGsllssLuahsLSh-thRlLIVluhLhTssMLYHppLRHalLLPSClALluGlhLhhhshp.G	.....MLQRTLGSG.WGVLLPGlLIsGLhaADLSsDQWRIlIlhGLlLTslMLYHKQLRHYlLLPSCLALIuGlMLhlMNlNQG......	0	1	9	21
+7086	PF07258	HCaRG		HCaRG protein	Moxon SJ	anon	Pfam-B_17801 (release 10.0)	Family	This family consists of several mammalian HCaRG(hypertension-related, calcium-regulated gene) proteins. HCaRG is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. HCaRG is a nuclear protein potentially involved in the control of cell proliferation [1]. 	20.70	20.70	20.80	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.74	0.71	-4.73	74	1021	2009-01-15 18:05:59	2003-09-12 10:30:12	9	19	136	1	629	1011	16	157.10	16	82.18	CHANGED	lshlsplspp.t.......htplhp....hshptlpttpstp................................htphtp.ht.....hstp..................phpt.lhpulthllppuspt...shsppphpppL.ppht......lsp-.ptpslsphatppppplpptltppsht.hsp.Lpsl..........pWRlclpluSsph..pc...htpPhhhl.pLplpss.......tp.pslshEhshsplppllpplcphppphpsh	.................................................................................h........s............h..hhp.hhp..l.h..t.t.t.p.................................h..thtt..ht.......h.s..t......................phpt.hltshth.lhpp..s.spt........shst..pphp.ppL..t.p..ht....................h.sp..-.tt.......phl.s.p.h.at...........p.p.p.pp.lp.pt.h....h.p..pt.......ht...hsp..ltsh..........pW..+ls.hp.h.u.o.sph...pp...........htpPhhhl.pLplpps.......................tp.p.th.thphsh..tphpphhtplpphtt.hpt..........................................................	0	238	284	439
+7087	PF07259	ProSAAS		ProSAAS precursor	Moxon SJ	anon	Pfam-B_17813 (release 10.0)	Family	This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 [1] may function as a neuropeptide [2]. N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease [3].	21.70	21.70	21.80	82.20	20.90	21.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.28	0.71	-4.76	2	25	2009-01-15 18:05:59	2003-09-12 11:08:19	7	2	17	0	12	20	0	165.00	77	74.38	CHANGED	MAGSPLLCGPRAGGVGILVLLLLGLLRLPPTLSARPVKEPRSLSAtSAPLVETSTPLRLRRAVPRGEAAGAV.thu............tRututsttucDppARVL.tphLR.....uWtS.........PRsp..PLAPDDDPDAPAAQLARALLRARLDPAALuAQLVPAPAsAPRPRPPVYDDGPphP..cctGscp.Dh	......MAGSPLLtGPRAGGVGLLVLLLLGLhR.PPsLsARPVKEPRuLSAASsPLAETusPRRFRRAVPRGEA.AGAVQELARALAHLLEAERQERARAEAQEAEDQQARVL.AQLLR......sWGu.........PRsSDPsLu..DDDPDAPAAQLARALL.RARLDPAALAAQLVPAP..A..A..Ah..R...PRPPVYDDGPsGPDsE-AGDETPDV..	0	1	1	2
+7088	PF07260	ANKH		Progressive ankylosis protein (ANKH)	Moxon SJ	anon	Pfam-B_17517 (release 10.0)	Family	This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralisation and bone resorption [1]. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterised by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones [2].	20.70	20.70	21.10	20.70	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.25	0.70	-5.45	2	82	2009-01-15 18:05:59	2003-09-12 11:17:30	6	2	49	0	46	68	9	277.50	65	67.24	CHANGED	Mhch.S.TsYWPLIRFLlPLuITNIAIDFGEQALNRGIAuVKEDtlEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK+-t.KAlLCMsVAGlIAhlhHsLIAYoDLGYYIINKLHHVD-SVGuKTRKAFLYLAhFPhhDAMAWhHAGILLKHKYShLVGsASISDVlAQlVFVAILLpSpLEChEPLLIPILuLYhGALVRhTslsLGYYpNlHDhhPESous-.GGDATIKKMLSFWWPLALILATQRISRPIVNLFVSRDLtGSoAuTEu.................hT-hpuh.PhF..................TtIcphphsshuLSLoL.....Wo	...........................llpFhlPLuloslshshucQALNRGIAuVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNS.K..RD.RsKAVLCM.V..VAGslAuVhHsLI.AYoDLGYYIINKLH.HVD-SVGsKTR+AFLYLAAFPhhDAMAWhHAGILL.KH.KYShLVGsASISDVlAQ.....lVFV.AILLHSpL.......ECtEPLLIPI..LSLYMGALVRhThls.L..GYYpNIHDhIP-pSGsEhGGDATI+KMLSFWWPLALILATQRISRPIVNLFVSRDLtGSSAATEAVAl.LTATYPVGHMPYGWLTElRAVYPAFDKNNPSNKlhsssssVTtsHIK+FTFsChALSLoLCFlhFWT.............................................................................	1	12	17	25
+7089	PF07261	DnaB_2		Replication initiation and membrane attachment	Moxon SJ	anon	Pfam-B_17543 (release 10.0)	Family	This family consists of several bacterial replication initiation and membrane attachment (DnaB) proteins, as well as DnaD which is a component of the PriA primosome.  The PriA primosome functions to recruit the replication fork helicase onto the DNA [2]. The DnaB protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110 in Bacillus subtilis. It is known that there are two different classes (DnaBI and DnaBII) in the DnaB mutants; DnaBI is essential for both chromosome and pUB110 replication, whereas DnaBII is necessary only for chromosome replication [1]. DnaD has been merged into this family. This family also includes Ftn6, a cyanobacterial-specific divisome component possibly playing a role at the interface between DNA replication and cell division [3]. Ftn6 possesses a conserved domain localised within the N-terminus of the proteins. This domain, named FND, exhibits sequence and structure similarities with the DnaD-like domains Pfam:PF04271 now merged into Pfam:PF07261.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.39	0.72	-4.38	110	3374	2010-01-07 15:44:22	2003-09-12 11:29:14	6	17	1459	3	391	2143	21	75.80	23	26.80	CHANGED	lhphhcpp..hup.LSsh-hcplppalpp...phss-llphAlcpAl.tp..schs..h+YlcpILtsWpcpslpTlcpspphtcp	.........................hphhppp....ht..t...los.h-h....cplpphlpp........phss-....llphAlchuh...p.......schs.........hpYlp.p.ILpsWpc.p.s..lpThcpspth...t...............	2	151	271	328
+7090	PF07262	DUF1436		Protein of unknown function (DUF1436)	Moxon SJ	anon	Pfam-B_17809 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 160 residues in length. The function of this family is unknown.	25.00	25.00	25.10	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.63	0.71	-4.75	9	103	2009-09-11 13:43:21	2003-09-12 11:34:26	6	1	77	1	17	82	1	145.10	44	86.54	CHANGED	pch.sthphTscFlSlpoYSGhshhshDshtssplLsPDlsspslGcsILpALScSRhl..s.--.t.sFhDhEptp.pYcsWlpplMtpYuY+o++uLFKsMh.suIpllNs.IpIpPo+H-KLEuWosst.psu-hVhl..slDsSPEElGuuL+.AFp+C	........................h.s.h.hstchh.lpohuthshhs.D..hsspl...Ls.DsDspsLGpslLQALusSRTh............cs.Epp.-FFcpEch+p.cYc-WlspLhsphGYKT+RALFKNMhsssIh..lpNuslcIoPS+HsKLEAWsuh....-uDsVlL..slD..sSPEEIGAuL+LALSRC....	0	3	8	12
+7091	PF07263	DMP1		Dentin matrix protein 1 (DMP1)	Moxon SJ	anon	Pfam-B_17812 (release 10.0)	Family	This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21 [1]. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin.  DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation [2]. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown [3].	19.20	19.20	19.70	19.60	18.60	19.00	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.11	0.70	-5.77	4	486	2009-01-15 18:05:59	2003-09-12 11:45:14	6	2	401	0	21	468	0	337.60	57	98.59	CHANGED	MKToILLMFLWGLSCALPVARYQNTEScSSEEhKGcLAQoPsPPLESSESSEESKlSSEEQANEDPSDSTESEEtLGhDcpQY.aRPAGGLS+SsGptG-DKDDDED-SGDDTFGDDDuGPGPEEtp.GGsSRLsSDEDSsDTTQSpEDSsPQG-sSAQDTTSESR-LDsEDEsDSRPEGGDSTtDSESEEpWVGGGSEGESSHGDGSEFDDEGMQSDDPtohRSERGNSRhSoAGlKS+ESKGcDcEpASTQDSs-SpultasSRKhFRKSRlSEEDsRGEL-DsNoh.EVpSDSTEs.....stLoQS+EcS+uESQp-ScENpS.E-SQcVQDPSSESSQEssLPSQENSSESQEEsluESRGDNPDNsTSau.EDQEDS-SSEEDSLcp.SsSESpSpEEQADSESpESLp.SEESPESsE-pNSSSQE.GLQupSuSsESpSQ......-ShSEEDD.SDSQDSSRSKE-SNSTESsSSSEE-uQsKNhElESRKLTVDAYHNKPIGDQDDNDCQDGY	.................................................................................................................................................................tt.oRhts.........s-DSuDsTpSp...E-Sssp.E-......us.......p....D..s......s..S......-......S+sh.-pE....................S-SEEaWVGGGS.E.G.-.SS.HG.D..............GSEF...DD..EGMQSDDPD....ol+S..ERupSRMs..S..Au.l..+SKE...S..psp.s.c.c.p.ussQD.S.s-.SQSV-psuR.KhFRKSRIS..t..EDDpu-hssSsoh..E.spSDSTEso............ppus.u.....Q...S+Es.SKS..-SQEDSp..E.s.QSQED..SQs.pDs...SSES.S....QEsDh.PSQE.....sS..SESQE..E..lh.ucSRGDNP..D.s...s...o.s...p...u......ED.Q-D..S.-...SS...EEDSLspsSsS.ESpScEEQAD.SE...SsES..L.p.SEES.ESoE..-ENSS.SQE.GLQSpSuS.s.E..SQ..S...........p......................p.....S.S.E....E.-..s..ps......Q-...s.s....c...S..........ts....S.sp-......p...-h-s..................................	0	1	1	5
+7092	PF07264	EI24		Etoposide-induced protein 2.4 (EI24)	Vella Briffa B	anon	Pfam-B_17540 (release 10.0)	Family	This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53 [1]. It has been suggested to play an important role in negative cell growth control [2].	31.50	31.50	31.50	31.50	31.40	31.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.81	0.70	-4.91	191	1863	2009-01-15 18:05:59	2003-09-12 11:56:43	6	6	1751	2	510	1310	173	215.70	27	82.70	CHANGED	suhttulp...tht................psphhthllhslhlsll....lhsshhhh..hhthltshh................................hshl.sh...............................hhhthhhhlhhhll...hhhl...hsslsshlsuhF.......hshluctl................................ptc.phsp.......hsthtshspul...hpplttlhhhlhhh..lhsl..hL...hh.lP..sl...s.hh..llahhlsu.....................ahhuh-ahshs.........h......shpctc.thhcpptsthhuhGhhhsh..............hhhlPllNllh.Pl	.............................................................................................................................................................uhhhhhpshthh...............pPtltph.lllPlllsll....Lhsu....hhah....hh.stlssa...ls.slhshhs.........................sWlphh...........................allh.lsslshlll..........hsah...hss..lushI.uusF.......ss.hlAEpl.........p.............................................sst..phss........shhshhtsls...+hh...tc.ph..p.p....hhh.h.l...sts....llhl....lL....ha.lP....sl...Gthlssllaalhsu.................................ahlulp.Yt-as............hspp.........hshcch+.shl+.p.p+h.t..shtF.G.slsuL........................hshlPllNLhh.Pl................................................	0	150	292	412
+7093	PF07265	TAP35_44		Tapetum specific protein TAP35/TAP44	Moxon SJ	anon	Pfam-B_17587 (release 10.0)	Family	This family consists of several plant tapetum specific proteins. Members of this family are found in Arabidopsis thaliana, Brassica napus and Sinapis alba. Members of this family may be involved in sporopollenin formation and/or deposition [1].	25.00	25.00	163.30	163.10	18.70	17.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.68	0.71	-4.34	5	15	2009-01-15 18:05:59	2003-09-12 11:59:58	6	1	7	0	5	15	0	121.30	65	99.95	CHANGED	MSpISKVSSLCLLLLshFFLSSQPALSLRuPKhQ.SEPsS.................PEolhsDSSSsMsKI.DpssAKSMIAGFFSHKFPLpGWPF.KYPPFoM...VNPNIP..TNPS.....GAQEEoEKLPSSPSKGNKDGGNA	.MS.IS+VSSLCLLLLV.hFFLoSpPALSLRuPK.Q.SEsAS.................PQThhDDSSs.Ms+I.D..pAKSMIAGFFSHKFPlpGWPFPKYPPFoM...VNPNlP..TsPS.....GAQEESEKlPSSPSKsN+DGtNA	0	2	2	2
+7095	PF07267	Nucleo_P87		Nucleopolyhedrovirus capsid protein P87	Moxon SJ	anon	Pfam-B_17842 (release 10.0)	Family	This family consists of several Nucleopolyhedrovirus capsid protein P87 sequences. P87 is expressed late in infection and concentrated in infected cell nuclei [1].	25.00	25.00	29.20	29.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	654	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.36	0.70	-13.24	0.70	-5.84	6	50	2009-01-15 18:05:59	2003-09-12 13:14:04	6	4	38	0	0	51	0	343.30	28	61.12	CHANGED	MD-p.NSLLIA+LAGpILTRDhsAVssIhHoPE+SLsQKLDsLpshlpuhssus.s.ss......suclphNShllsQshllRapsLphAVsFL+Ruspl..slspphLspIQssLppYcsYVspsshDpsl.l-saLNpAEssYtEIR...pscIh.FlK...................phpt.t.ppscups.sspsssu.....sPh......................................+.ssphhpthtN...pouhochspplpuu...hh.hth.h.th.p.pDpchphha.....................................tsh.pps.....EhPlIsNEpDFD+hsI-QLs...DYI++Nhss.phsas.sHsS...VcDVRpFAKslWRtps................ssspTPh..........ph.oPtpTPh.h.....s-p..uhQoP..sPt............................s.ps...hph.p................s.hPspssssss.ss.p+++RRRsssL..hs.....................S-E-E..............s-.cEsDaEp-RKRRREEDKNFLRLKALELSKYAGVNERMEKIVQVT+AMQcTYDYCNCKNTIsGTPsAssFspLL+RLNTYNLuHVEMTVNFYELLYPLTLYNDESN.......RIluYIFAAuNYFQNCAKNFspMRs-FNpaGPFsQIDSMVMFVIKFNFLCDLQsFFGpIDsLPsLuQPNhplHsVLlMRDKIVKLAFNuLQYsTssKo-NRRDPKHLQRLIMLMNADFNII	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sst..satshlpplpphNLohlp.sVpFYcLL.PLshYs...s...sp...s.......pllh...aIhtussYF.NsAcNFs.hRtshps.t.htphDphshFhI+aNFLh.hRpFhspl......s.shss..N.+IhNVLhhhDplVpptasplpaph...........................t..........................	0	0	0	0
+7096	PF07268	EppA_BapA		Exported protein precursor (EppA/BapA)	Moxon SJ	anon	Pfam-B_17945 (release 10.0)	Family	This family consists of a number of exported protein precursor (EppA and BapA) sequences which seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). bapA gene sequences are quite stable but the encoded proteins do not provoke a strong immune response in most individuals. Conversely, EppA proteins are much more antigenic but are more variable in sequence. It is thought that BapA and EppA play important roles during the Borrelia burgdorferi infectious cycle [1].	24.30	24.30	24.80	25.70	24.20	24.20	hmmbuild  --amino -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.58	0.71	-4.50	7	89	2009-01-15 18:05:59	2003-09-12 13:19:13	6	2	21	0	2	84	0	119.70	57	82.41	CHANGED	sIccNYs+AKKsFSKEDasLIpKRLDNYsFpsEYsKShhFuh.APcIRGsLRKIGIKEpuVhLDALDllGYLIKsKlhtphhhl....h.sI.pLIpGhPsuIFNaL.lQLsSDKIDYsEKYG-cAR-pFcpSYpKsKIssVK	.......IccNYscsK+uFScEDFsLIppRLDNYsFc..sEY-KShhhuc.sPcIRGpLRKItIKEpuVhLDALDlltYLIK.Khhp...lhh.........sI.pLItGYPsu.....IFsYL.IQ.LsSDKIDYAEKYG-cA..Rp..pFccuYp+DKhssVK............................	0	2	2	2
+7098	PF07270	DUF1438		Protein of unknown function (DUF1438)	Moxon SJ	anon	Pfam-B_18024 (release 10.0)	Family	This family consists of several hypothetical proteins of around 170 residues in length which appear to be mouse specific. The function of this family is unknown.	25.00	25.00	115.70	50.70	21.80	16.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.06	0.71	-4.33	5	19	2009-01-15 18:05:59	2003-09-12 13:30:23	6	2	3	0	4	16	0	126.80	58	89.06	CHANGED	MhpSFsGFVKDTSDTEEHALPSAQsLPALSTRCSKSETLCFuKEpSHCSEDGWIlDWDLY.h.CVFESVDYLRSY+RLNCAMKKGTEVFQSESQR-PQVSPGDVDNspDKDTEEPDQPhPSLLREKGLELETCDGGDCPDQDPASDSsRHLG	...hp.h.uFV+soScottHALPoAQVLPA.sstCshspsLpFutE.SHC.EDGWIspWs.ash.CV.tShDYLR.hppLNsAMK+GTElFQStoQRcPph..G.h.....psstcPDQP.PuL..LRcKGL-LtTC-GGDCPDQDPuSDSsRpLG.	0	0	0	1
+7099	PF07271	Cytadhesin_P30		Cytadhesin P30/P32	Moxon SJ	anon	Pfam-B_18052 (release 10.0)	Family	This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localised on the tip organelle. It is thought that it is important in cytadherence and virulence [1].	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.35	0.70	-5.13	3	109	2009-01-15 18:05:59	2003-09-12 13:35:59	6	8	24	0	13	105	16	133.40	46	68.80	CHANGED	McLss.hRhKKLFllutLLhsolLFSuLIlLATul.LVpcNsoE........psLsVVLHpsED.TssIQGRsITEQPWFIPTVAGuFGFSALAIILGLAIGLPIVKRKEKRLLEEKERQEQlAEQLQRIS.-QpEQQAlE.pPstEspsQupsQPAs.sVsssP.....QPQVQ.sFGPp.QQRls..RsGFP.QPN.Mu.RPGFN....QMPPH....PGMsPN....RPGFNP.P....GMsPRPGF........PH....PsMsPNMp..RPGF.pPQP...........GtFs+PGsPhsPNMt.RPGFsPN.GMsPsPuMtsPRuGhPP	.......................................................................................................................................................................................................................................................................................................PNpMGMRPGFN.....QMPPQ.....MGGMP..PNph..hRPGF.NQMPPp.........sGM.PPRP...NF..............PNQ..M..PNMp..+PGh.pspP...........Gh.................................................st..t........................	0	3	6	12
+7100	PF07272	Orthoreo_P17		Orthoreovirus P17 protein	Moxon SJ	anon	Pfam-B_18125 (release 10.0)	Family	This family consists of several Orthoreovirus P17 proteins. P17 is specified be ORF2 of the S1 gene and represents a nonstructural protein which associate with cell membranes [1].	25.00	25.00	53.90	53.90	23.20	22.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.94	0.71	-4.40	6	41	2009-01-15 18:05:59	2003-09-12 13:42:50	6	1	25	0	0	29	0	135.80	57	98.51	CHANGED	MpthR+poFsVpcF-...FsP.hlpphhpPshoAlstsDsstYhNI-lspoHPhhssLssLLup..PssVHVpLlRRauL.SoLssICEaDCsLltlssh.h..sosspsS+lVVHaDstoQSsAAKRSRslDslhDFEhEYK.WRFus.h	MQhLRHTTFcVpRFs...FsPlslpEhAhPSFTAITusDPopYFNIELPpoHPLhSpLPsLLSp..PCcVHVpLIRRFALaSTLSSICEYDCALLhsspAIh.LssusppSplllHWDGtSQSlAAKRuRphDTllDFE+-YK.WRFsu..l..	0	0	0	0
+7101	PF07273	DUF1439		Protein of unknown function (DUF1439)	Moxon SJ	anon	Pfam-B_18280 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.	20.70	20.70	21.10	20.70	20.50	20.30	hmmbuild  --amino -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.69	0.71	-4.49	38	831	2009-01-15 18:05:59	2003-09-12 13:49:14	7	2	797	2	138	426	24	148.20	48	78.82	CHANGED	loEpElppa....Lscch.phpcphGhsGlhssplplsslslpIG.pp.ssclslsusupsplssh.hsshssplplplcutPhYDp-csAlYL+slcLlchslpspphpsslps.lhs.lhphlsphLsspPVYpLcpsc.hspulh+phspslcVcsGc	......................................IoEQEINQu.....LsK+N.NFsK.cIGl.....P....GlsDA+IsLoNLsSQIGR-E..PNKVo..LTGDAplDhsSL.FGsQcAshKLpLKAlPsFD+....EKGAIaL.....+-MEVVDsoVp..PE....KM.....QoV.....hQo.LlPYLNQu.L.+.sYFNQpPAYVL+EDsSpuEAhAKKLAKGIEVKPGc..................................	0	19	54	94
+7102	PF07274	DUF1440		Protein of unknown function (DUF1440)	Vella Briffa B	anon	Pfam-B_17831 (release 10.0)	Family	This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.	30.90	30.90	31.10	30.90	30.40	30.70	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.92	0.71	-4.17	27	965	2009-01-15 18:05:59	2003-09-12 13:51:36	7	1	896	0	73	342	0	139.50	50	77.98	CHANGED	llSuhVKhGWEs.hPPRTP...............................pRstsNPPt....thL.p.lGlssp.spssYhausp.plsasuhllHauFSlsFA..lhYs.lluchaPplphhpGssaG.lhlalshHhllhPhhthsPss.........hc.PhpEHhSEhlGHIlWhWoI-.....ll	.....................llSuhVKhGhEVshPPRoP.................................pRsthNPP.....hhL.-.LGlss...spssYTFusp.hhsaVu.lsHhhFSIVFA..lsYC.llAEhaPKlpLWQGhlhG.lllhlhhHhIhhPlhshsPsl.........a-hPatEalSElhGHlVWhWoIEll..............	0	11	30	56
+7103	PF07275	ArdA		Antirestriction protein (ArdA)	Moxon SJ	anon	Pfam-B_17857 (release 10.0)	Family	This family consists of several bacterial antirestriction (ArdA) proteins.\	      ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification [1].	21.00	21.00	21.10	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.27	0.71	-4.00	38	992	2009-01-15 18:05:59	2003-09-12 13:53:08	6	11	631	4	85	617	101	159.80	30	62.10	CHANGED	clYVAsLupYNpGpLhGpW..lssstDt--ltt.hcclhhs......tp.........................................EEaAIHDaEshs...thplsEYssl-clsclsph.l...........p-hs.-st.tth.thh....saaus.p-hsp..cslcsh.ahuphcs.p......DhApthl--ss......hptlP.pp..L...ppY..hDYEAauRD....lplssshh..hsppGhhpst	...................................................................tlYlushu+Y.N.pG..plsGtW...hohP.h...Dh..--hp...c.clsls.......-p.........................................cE..ah...Ip..Da...E.hP.........hpl.s......Ea..s.slt.clN..clhch..l..............p-ls..cthtpt.hpthl......................shhu..s...h...p-h.p...h..csltph....h.......s-s.c.s.p....................DlAphhl-..-sG.......hl.s-lP....p.s....l...psY....hDY-AYGRD....Lthsuphh..hspcGhh...h...........................	0	37	63	74
+7104	PF07276	PSGP		Apopolysialoglycoprotein (PSGP)	Moxon SJ	anon	Pfam-B_17916 (release 10.0)	Repeat	This family represents a series of 13 reside repeats found in the apopolysialoglycoprotein of Oncorhynchus mykiss (Rainbow trout) and Oncorhynchus masou (Cherry salmon). Polysialoglycoprotein (PSGP) of unfertilised eggs of rainbow trout consists of tandem repeats of a glycotridecapeptide, Asp-Asp-Ala-Thr*-Ser*-Glu-Ala-Ala-Thr*-Gly-Pro-Ser- Gly (* denotes the attachment site of a polysialoglycan chain). In response to egg activation, PSGP is discharged by exocytosis into the space between the vitelline envelope and the plasma membrane, i.e. the perivitelline space, where the 200-kDa PSGP molecules undergo rapid and dramatic depolymerisation by proteolysis into glycotridecapeptides [1].	17.30	17.30	18.20	22.10	14.70	17.00	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.96	0.74	-6.04	0.74	-3.39	3	74	2009-01-15 18:05:59	2003-09-12 14:03:55	6	3	4	0	0	72	0	13.00	96	81.03	CHANGED	DDATSEAATGPSG	DDATSEAATGPSu	0	0	0	0
+7105	PF07277	SapC		SapC	Vella Briffa B	anon	Pfam-B_17881 (release 10.0)	Family	This family contains a number of bacterial SapC proteins approximately 250 residues long. In Campylobacter fetus, SapC forms part of a paracrystalline surface layer (S-layer) that confers serum resistance [1].	25.00	25.00	35.10	34.80	19.70	17.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.20	0.70	-5.04	83	327	2009-09-11 20:32:24	2003-09-12 15:17:17	6	4	209	0	133	355	145	216.40	28	86.79	CHANGED	L.sspcHtsl+lpstps.hsaupshphlPlhssEFtpAsspaPIlFs.csspst...ahslAlhGlcpscNLFls.-GpWpus..YlPthlRRaPFhl..............tpspsssphslslDtsustl..s....ps-G..psLF.....spsGpsopaLpphhphLpphppstptTptFhptLtchsLLpshslslsh......tsupppslsGhaslsEc+LppLss-s................lhcLp+sGhLthIYspLhSLsplppL	........................Lss.pHtsl+lp..stps.htausshphlP....lhssEaspsstpaPIlFt.....csspt.........atslAlhGlpts.cN..L.Fl......s..sGpWpus..YlPshlcRaPFhl...............ts..tppsphslslD.sustl......s...........ps...cG....psLF.....tppG.psopaLpphhphLpphppshptTptFhptLtchsLLpshplslph........tsGpptplsGhaslsEc+Lpt.Lssps................lhpLpc....pGhLthlYstLhSltplppL................	0	36	85	107
+7106	PF07278	DUF1441		Protein of unknown function (DUF1441)	Moxon SJ	anon	Pfam-B_17966 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 160 residues in length. The function of this family is unknown. However, it appears to be distantly related to other HTH families so may act as a transcriptional regulator.	26.50	26.50	27.60	27.80	25.50	26.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.77	0.71	-4.57	9	388	2012-10-04 14:01:12	2003-09-12 15:26:14	6	4	271	0	19	155	8	132.20	50	88.03	CHANGED	cLNIsQlAtloGLHRQTVssRLtsls.PAsGospphKLYtLsDllsshhst.hsssssp.hDPs.....-RKAWaQSEp-RLKhE+EptpLlPssEVtppauslsKAlVQVLETlPDlLERDsuLoPstLscVQpllD-lR-plsptlh-sss-	.........................................................................LNIsQLAAloGlHRQTVsuRLpsls.sAsGptpphKLYhLsDllsthht..hP..s.ssst..tc..hDPp.....-RKAWYQSE+ERLKhEpEptQLlPso-VcppaulhsKAlVQVLETlPDhLERDpGLpsstlscVQpllD-lR-plthtlh-sss-.........................	0	1	7	12
+7107	PF07279	DUF1442		Protein of unknown function (DUF1442)	Moxon SJ	anon	Pfam-B_18012 (release 10.0)	Family	This family consists of several hypothetical Arabidopsis thaliana proteins of around 225 residues in length. The function of this family is unknown.	20.80	20.80	20.90	21.30	20.10	20.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.56	0.70	-5.24	4	79	2012-10-10 17:06:42	2003-09-12 15:28:21	6	3	17	0	57	104	0	202.80	33	86.19	CHANGED	MKLVWSPETAScAYIDTVKSCcshcssusAEhluAhAAGWNs+LIVETWScGDsIAoSVGLsVAupHTsGRHlCIVPspcScotYltAMpttsoo.shsEslV....uEpsEcsMcclpGVDFLVVD.+p+EFs.ssL+.Athus+GAVlVC+Nuhp+uhssFpWpclL.Rsp+VVRoVhLPVuuGLEIsHVuAssuGsuts....+pRWI+HlDpRSGEEHlF++	..................................................................................WSs-sA.cAYlpTlc..................s.....p.............p...h....p..............p....s..s.....s...........A...........EhlSAhAAG.NA+LlVpshup..u.........u..s...sToluLAsAA+..p...TsGRh..lCl.lPspps.hpthtpshtph.u.h.p....phsEhl...l..........G-t...scplh..tp.h.p.s.lDFllVDs+...p.c-ah..clL+....h..sc.hu..t..p.G.....A.VlVspN...u....hp..p..t.h.s.s.h..p.a.p.......tsh......pt.pph.V...+oshLPlG.pGl-ls+lusst......s.......spt..........tp.t....................p+Wlh+lDppoG-.ahh+........................	0	9	38	50
+7108	PF07280	DUF1443		Protein of unknown function (DUF1443)	Moxon SJ	anon	Pfam-B_18027 (release 10.0)	Family	This family consists of several Baculovirus proteins of around 55 residues in length. The function of this family is unknown.	25.00	25.00	56.40	56.20	22.20	19.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.00	0.72	-4.39	23	52	2009-01-15 18:05:59	2003-09-12 15:30:27	6	2	52	0	0	46	0	43.00	38	74.87	CHANGED	llllllFllslhlLhhL+LN+tQhpchLaYQYpYIPcsLlshV	.....hhllllFlhslhhLhhL+lN+tplpchLaYQYpYIPcsLlshV	0	0	0	0
+7109	PF07281	INSIG		Insulin-induced protein (INSIG)	Vella Briffa B	anon	Pfam-B_17905 (release 10.0)	Family	This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations [1,2].	25.20	25.20	25.50	25.30	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.75	0.71	-11.36	0.71	-4.97	9	298	2009-01-15 18:05:59	2003-09-12 15:33:33	7	4	190	0	172	256	0	182.60	36	62.95	CHANGED	psl+uslLFuFGVlaullshpL.......+cNahlhPVcLcsp+a.suW.h.uhaGhuusslG.lhPhlDoa..hGcs.................cchshpWsuVsRsVuAFVGIuaAh++LsapSoTQuSlTLAhssslLWYLhDRo+sGFhLSTlluluGssllhsLts.................ssh...hGlhphhoQ-.hhVRsWlsulLFsAsVsFGNIGRQLA	.....................................................................h...pshlLF.h.GhhhuhllphL..................ppp.h..h.l.....h.s..........c....l.....s...h...h...ss..sW.........h.h...s.......h..h...G..s..u..usllGhLhPhlDph....hs-s.............................................................pp.h....pppWsuV.hRslusF.....V......GIsaA....t.........Kl.......s.........ass..s....l...QlS........LTLAhLslsL...WahFDR.S+o....GhhLu.lsl.uhlusl..hh.hls....................................................................tu.lh.phso..-h.lhlt...sWlsslhFsuslshGNIGRpLA..........................................................	0	35	71	119
+7110	PF07282	OrfB_Zn_ribbon	Transposase_35;	Putative transposase DNA-binding domain	Bateman A	anon	Pfam-B_4755 (release 10.0)	Family	This putative domain is found at the C-terminus of a large number of transposase proteins.  This domain contains four conserved cysteines suggestive of a zinc binding domain.  Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesise this domain is DNA-binding.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.25	0.72	-4.32	72	6607	2012-10-03 10:42:43	2003-09-12 16:00:36	6	25	1414	0	1912	6323	252	69.10	32	19.70	CHANGED	atphtphlcYKAphh.GhplhhV...ssta.TSppCstCGphtpp.........hss+hapCsp..CGhp.hcRDhNAuhNIhpc	.....................ahphpphLpYKsp........h.h.G.t.p.l.l..t.V........s.ta...o..Sp.....p........C.......s......s.....CG..phtpp.....................tls.pR.p.a.....p.....Csp........C...G...hp....tc........RDh........NA.A.hNIht...............................	0	559	1281	1646
+7111	PF07283	TrbH		Conjugal transfer protein TrbH	Vella Briffa B	anon	Pfam-B_17942 (release 10.0)	Family	This family contains TrbH, a bacterial conjugal transfer protein approximately 150 residues long. This contains a putative membrane lipoprotein lipid attachment site [1].	20.40	20.40	20.50	23.50	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.46	0.71	-4.25	14	125	2009-09-10 15:49:04	2003-09-12 16:08:24	6	2	104	0	26	94	9	114.40	33	73.22	CHANGED	ussssptlAsDsVpQLstlYPPApTplpL.....pQtssDsFGtALlpsLRt+GYAVhEhssssttspu....................slsLpYVlDphssosLYRLTl.lGsQoloRsY.lspsushhPAusWs.RKE	.......s...stptlAsDhlppLsphYsP.A.+..T.phpL.....p.p.p.sss.sFGpALlpsLRpcGYAllp.ssssstst................................l.LpYll-phss.ps..LhRlo..lsspplsRsY.hspssshhPuu.hs.h...................................................	0	3	13	21
+7112	PF07284	BCHF		2-vinyl bacteriochlorophyllide hydratase (BCHF)	Vella Briffa B	anon	Pfam-B_17961 (release 10.0)	Family	This family contains the bacterial enzyme 2-vinyl bacteriochlorophyllide hydratase (EC:4.2.1.-) (approximately 150 residues long). This is involved in the light-independent bacteriochlorophyll biosynthesis pathway by adding water across the 2-vinyl group [1].	25.00	25.00	25.70	45.20	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.92	0.71	-4.33	26	115	2009-01-15 18:05:59	2003-09-12 16:40:04	6	1	97	0	54	112	133	138.10	55	81.21	CHANGED	YTPEQhuRRsuSlWThVQuILAPlQFllFLlSlsLVlhYhssG..pGahhsolSIlhKTlhLhhIhlTGAlWEK.VFG+alFAstFFWEDVsShlshAhHshYhlhha.sthsspshhhlAlsAYsoYVlNAhQFLl+.lphu	.YTPEp+tRRDuosWThVQGILAPlQFlVFLlSLsLVlpYLsTG..pGahhAThSlllKThlLasIMlTGuIWEKsVFGpYLFAPuFFWEDVhShlVlALHouYlsslh.shhsspt.MhlALAAYuoYllNAuQFLlK.LRhA.....	0	10	20	37
+7113	PF07285	DUF1444		Protein of unknown function (DUF1444)	Vella Briffa B	anon	Pfam-B_18053 (release 10.0)	Family	This family contains several hypothetical bacterial proteins of unknown function that are approximately 250 residues long.	22.40	22.40	22.40	22.40	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.47	0.70	-5.06	18	530	2009-01-15 18:05:59	2003-09-12 16:42:35	6	4	507	0	70	307	1	250.70	46	91.43	CHANGED	Msscphp-hLccRLs.psshsapaDRcc-sLRIcc+pstKGlTlsLssllAKaccpt-cAl-EllYYVpEulpsM..ppcsp.hpsp-ppIaPVIRuTSFPpco+-Gp..sLlac-HTAET+IYYALDLG+oYRLIDEphLcc.shTcccI+EhAhFNlRsLssshKpDcVAG...NhFYFlsoNDGYDASRILNcuhLp-hpppspGchsluVPHQDVLI.lADIpN-sGYDVLAQhoMcFFspGpVPITuLSFlY-pGcLEPIFILuKs+.+c	............................................................................................................................MsshpM+-cLcc+Lp..+.chcFpas+.....Ec.-sLRI.pp..c.sp.KG.ls..lp..LsullAK.YEsp...K....E..c.h....l-E.ls..........Y.YVpEAlttM...tccs......p.sp....spIhPVIR...uT.....S......Fsc....p..s..........+......pGh..............sF.l.h.c-.....HTAE.TtlYYAlDh..G.K.o.........Y.RLIDEphLpch.pLT.c.p.p.lREhulFNl.Rp....L....ss.p..h...p...p.DpV.pG.........NhFY..FlNoNDG.Y.DAS..RIL.N.suh....Lpc.hct..p.....h..p.G.-.M..l.VAV.PHQDVLI.I.ADI...cNcsGYDlhA...ph...TMcFF...sc...GhVPITSLSFsYcpG+lEPIFILuKNphp..................................................................	0	24	45	61
+7114	PF07286	DUF1445		Protein of unknown function (DUF1445)	Vella Briffa B	anon	Pfam-B_18180 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within a number of hypothetical bacterial and eukaryotic proteins of unknown function.	25.00	25.00	26.20	28.30	21.20	24.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.74	0.71	-4.53	77	578	2009-01-15 18:05:59	2003-09-12 16:55:20	7	5	524	3	217	535	202	139.80	52	46.66	CHANGED	VuFllGCSFoFEpALlpuG..lslRHl-pspNVPMY+TNlsspPAGhFsGs.hVVSMRPhsssclh+AlpITuRaPss.HGAPVHlG.DP.ptlGIpDlspPDaGDsV.slcsGE............lPVFWACGVTPQsslhsu+...sshsITHuP...GaMllTD	...................VuFllGCSFSFEpALhcsG..lslRHlp..p.spNVPMY+TslsCpsAGh.Fp.....Gs.hVVSMRPlss.spshcAhpITu+aPsV.HGAPVHlG..cP..p.....tl..GIp...Dls+P...DaGDsV.pl..c.sG.E.............................lPVFWACGVTPQuslhsu+.....sshsITHAP...GaMhlTD................	0	58	114	173
+7115	PF07287	DUF1446		Protein of unknown function (DUF1446)	Moxon SJ	anon	Pfam-B_17949 (release 10.0)	Family	This family consists of several bacterial and plant proteins of around 400 residues in length. The function of this family is unknown.	20.10	20.10	20.10	20.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.86	0.70	-5.98	79	939	2009-01-15 18:05:59	2003-09-15 10:38:20	6	15	655	0	436	933	748	308.70	30	63.05	CHANGED	IGsuuGahG...DRhpsshcls....p......tGslDaLsh-hL....................AEhThulht.......ps+hccPs.tG................Yssthhp..phcssLshshc......+Gl+lloNtGuhNPpu.....sActltplApchGLs.l+VAhVp.....GDDlhspltt.....tst..p.hpsut.sh.t...t...hl............SANAYLGAhuIscALctG.ADlVlTGRVsDsulhluPhhacFGWs.hsDaDcLAtuslAGHLlECGuQsTGG.Fuc..ac-l....s-.htpl..........GFPIAElssDGsslITKhs.GoGGhVohsTVpEQLLYElpcPtsYlsPDVsuDasslplp.....phGsDR..................V+V..sGspGps....Pss.hKVslshhsGahspsphshsG.ssht+Aclstchlpc+lttt.........sclch-LlG	...................................................................................................lussuuh.u...Dp..sh.thh.....p...........s..lshlhh.-hL....................uEhsh.hht..........tp...t.pst.....G........................Yt.......hhp..thc.....hLshs....hc......p.sl+l.lsN.....s.....G...uh..sP..tu........hsp.tlpplupc..hGls...h+lAhlt...GDslhshhtphh..........t.......h...s....h.........p.............h..........................sssAY...lGu.sIhcALct....G..A..D..lVlsGRssDsulhhu.s.hh.htasWt.....hs..D......aD.pL..utuhhsGHllECusps.oG.G.ast.........ht.h...............t.h.p.GaPl.uEltsc....GphlloKh.....s..oGGhlo.sTlstQhLYElpsP.tYh.sPD.......Vsschsplp.hp.....ph....u.s.c.R..................Vpl..sGsc....G.p..s.s.....P.s.s...hK.lsh..shhsGapsts.hshsG.t...h.t+u.chhtc.lpptltth..............................................................	0	119	255	370
+7116	PF07288	DUF1447		Protein of unknown function (DUF1447)	Moxon SJ	anon	Pfam-B_18163 (release 10.0)	Family	This family consists of several bacterial proteins of around 70 residues in length. The function of this family is unknown.	25.00	25.00	25.50	25.30	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.34	0.72	-4.19	33	1005	2009-01-15 18:05:59	2003-09-15 11:09:40	6	1	979	0	87	267	1	70.70	51	96.82	CHANGED	IYKVaYQcsppcsPhREpTcoLYl......EA-ochcsRphl-cp..sYNIEFIp.LsGpaL-YEKpsssFclsEa	.....IaKVFYQEs+ccsPhREsTcoLYl......Eu-uchpsRphlc-p..sYNIEFIphLsspaL-YEK.E.s..u.s.FplsEh......	0	18	42	65
+7117	PF07289	DUF1448		Protein of unknown function (DUF1448)	Moxon SJ	anon	Pfam-B_18223 (release 10.0)	Family	This family consists of several eukaryotic proteins of around 375 residues in length. The function of this family is unknown. It appears that this family includes a divergent GRAM domain.	20.40	20.40	30.00	27.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.04	0.70	-5.52	13	172	2012-10-04 00:02:25	2003-09-15 11:11:37	6	9	121	0	110	157	4	282.90	47	87.44	CHANGED	thWpDR-l+FD.lsspplphp..sGEtllshlssVEDTKGNsGcpGpLhVTNLRlIWaupsps+hNLSIGassItslss+.ps..pS+lRG.sopuLaIhu+..ssssRFEFlFT.............................ssstpssp........lFsolhsVa+sYpooplYR-LKLRuAllp.sGpLplLPpEplhs+lsGVhNlSu-QGsL.GoFhlTNlRlVWaAshN-sFNlSlPYLQIpulRlR-S.KaGhALVIETsppuGuYVLGFRlDPh-+LschhKElsSL+psastpPlaGlphphc....-ssttt.............psp..................s.p.pp--sE.l-schcsD...thsuYhAs..sspt.....sp-Rc....PlYssELGLAlE+l+sGhoLp-LWslh	...........s.hWpDR-l+FD..lstpthphR..sGEhll-plsslEDTKGNsG.....-pGpLhVTNLRllWaSh.shs+.hNLSlGasslhslss+.hs....pSK.........lRG.topA......LYIhs+........hs..soRFEFlFT.............................slsstss..........lFsolhsVa.+AYcoo+hYR-lKLRu.A.llp.stpLhlLPpEplas+lpGVWNLSo..D...............QGNL.GoFhlTNlRlVWaAshN-sFNlSlPYLQlp..ul+lR-S.KFG.ALVlcosp.puG.GYVLGF+lDPhE+LpphhKElsSLHpsastpPlFGVpaphc....-t..t.h.......ct................................s.p.h.--hE.l-p.p.pp-......shsuYaAs..ssp........ttpRt.......Psas.cLGlAhEtlhpGholpsLWpl....................................	1	50	59	90
+7118	PF07290	DUF1449		Protein of unknown function (DUF1449)	Moxon SJ	anon	Pfam-B_18269 (release 10.0)	Family	This family consists of several bacterial proteins of around 210 residues in length. The function of this family is unknown.	21.60	21.60	22.10	22.10	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.25	0.71	-4.98	3	565	2012-10-02 01:11:51	2003-09-15 11:14:22	6	1	525	0	47	238	9	190.70	56	95.09	CHANGED	FA-YNoPYLFAIAFVllIGlLElloLIsGHhLSGALDAHLDHYDulSoGsluQALHYLNIGRVPALVVLCLLAGaFGLhGILIQHuuIMVWQuPLSNLllVPlSlllSVhAVHYouKIlAPWIPRDESSAlsEEEaIGuMAlITGHsAsuGsPCEGKlTDpFGQIHYLLLEPE.cGK.FcKGDKVLIVCR....LSATRYLAEpsPa	..............................................................FA-YNoPYLFAIuFVlh..IGl..LEhhuLIhGHh.......LS.......GA...L.........D....A....H..L........D...H.........Y.........D...u......l......o...o..G..........h...u...Q.....A......L.H....YLNIGRlPALVVL...CL...LA...GaF.G.LhG..ILlQH...u.s.lhl...WQ...uP...LSNL....h......l.....V....Pl.Sll..h..olhAVHYoGKllAPWl.PR..Dc..SS...A...loEEEaIGuM.AlI...TG.Hp...A...suGsP.CEGKlTDpFGQIHYLLL.E.PE..cG.K..F.pKGDKVLIlCR.....LSATRYLAEps.a...........................................	1	10	23	35
+7119	PF07291	MauE		Methylamine utilisation protein MauE	Moxon SJ	anon	Pfam-B_18306 (release 10.0)	Family	This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.17	0.71	-4.66	5	457	2012-10-02 13:32:46	2003-09-15 11:20:18	6	7	374	0	184	485	112	150.00	21	71.32	CHANGED	pslLs-PsVshhlRlFLALLLAAAAIPKLRHsEEFaGVVRNFRLLP-aLuRPVAhVLPllELulAVGLllPsLAslAAslAAALhlVFulAIAINVuRGRTpIDCGCFRNGhK.QRISWhhVhRNluLAuhALulAAlLPsAssuSlp-uATGLAAAuhLhLLYhuASLLuGLPAu+susclsKG	...................................................hhh..........hhhphhlu.hl.hlhuuhtK...lt...sh...t....s...F...t.p..t.l...t...s..Y.p...l..L..s....p...t.h..s...t....h.A....hhlPhhElhs.Gl...hLl.h.......u..h...h.........t...h.h..u...u..h..l.uh..h..lh..h..l.Fs..s.ul.....s.h.s.l.h.p..s..t.h.pl...c...CGC.....h........G.........s..s........st............l.u.....h.....h.........l.h..c.sh...h...h.h.hh...s....h....................................................................................................hhhh....................................................	1	82	146	168
+7120	PF07292	NID		Nmi/IFP 35 domain (NID)	Vella Briffa B	anon	Pfam-B_17864 (release 10.0)	Domain	This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localisation [1].	25.00	25.00	25.10	25.90	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.97	0.72	-3.94	4	209	2009-01-15 18:05:59	2003-09-15 11:26:57	8	4	39	0	112	182	0	86.40	37	52.28	CHANGED	ALITFEc.cVAppVlp.pcHpVphE-spL+VpspPl.LssssphQVpsplSph+l.VTGhPs..cLSEEphhDKLEl.FuKoRNGGG-V-	..............AlITFtcpt...VAppllphpcapltl.........p.psp.hpVplpPh..sphpchQl..psplSp..+p.lL..VoslPs..tlsE-pl.p.DhLElaFpKspN..GGGEVE..........	0	4	13	43
+7121	PF07293	DUF1450		Protein of unknown function (DUF1450)	Moxon SJ	anon	Pfam-B_18439 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 80 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.	20.90	20.90	20.90	21.50	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.65	0.72	-4.00	14	826	2009-01-15 18:05:59	2003-09-15 11:43:57	6	1	437	0	89	264	0	73.70	40	85.85	CHANGED	MpPllEFClSNLApGoptAhEtLE+DPNlDVlEYGCLoYCGhCupuhFALVNGEhVpG-oPE-LVcNIYpaIEENs...hF	...............................................p.h...hpcL.E..p.D..Ps.s..-llEhGC.oYCG.spcpsFAhVN..scsVtu.T.EELlpplhpplcc...............	0	29	56	73
+7122	PF07294	Fibroin_P25		Fibroin P25	Moxon SJ	anon	Pfam-B_18451 (release 10.0)	Family	This family consists of several insect fibroin P25 proteins. Silk fibroin produced by the silkworm Bombyx mori consists of a heavy chain, a light chain, and a glycoprotein, P25. The heavy and light chains are linked by a disulfide bond, and P25 associates with disulfide-linked heavy and light chains by non-covalent interactions. P25 is plays an important role in maintaining integrity of the complex [1].	25.00	25.00	45.70	39.70	19.40	19.10	hmmbuild  --amino -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.05	0.71	-4.83	5	11	2009-01-15 18:05:59	2003-09-15 11:48:57	6	1	8	0	5	8	0	184.30	46	86.22	CHANGED	NIVRPCaLDDLKCIuDNLAANS+CpsNVRGpIPSpYsIPsF+FEsPFFNATYIDaNLIsRN+DpCRVSEFFFNl+ocsuVLolDCPNLsaESsRTllQHtSLpEDoVYSYaINGTYPLIRLTTNLssusclNLCSuaTFADVs.uLPIF+IDPND+pTANaLSRDLoLLNIYERETFaaRustLARaFINSLICDFGCp	.pIhRPChLsDhcCIpDpLAANSpCpss.tGplPopYpIPhFpF-sPaFNATYlDaNLlsRNpDpC+VSEFahNh+ocpsVLolDCP.LsaESsRTlhQHtS.hpEDshhSaaIpGoYPLIRLTTsh.pusphsLCSuaTFADls.uLPIF+IsPpDp.TApaLS+DLoLLpIYEREphhh+ts.LhR.FlsphlCDFGCp.................	0	4	5	5
+7123	PF07295	DUF1451		Protein of unknown function (DUF1451)	Moxon SJ	anon	Pfam-B_18524 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein. The function of this family is unknown.	24.10	24.10	24.50	24.20	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.00	0.71	-4.42	31	784	2009-01-15 18:05:59	2003-09-15 11:51:52	6	4	781	0	106	305	19	140.40	57	90.58	CHANGED	lhppl....p-s.pps.cpLpchlcpucchhptts-hTc-ElsLlspaL+RDLccatcphp-.......t.hpushhthlcpoLWptLupITD+TplEWtELhpDhcHpG..hYpoGEllGhGtLsCppCG+phphppsshlssCscCspptFpRpsh	...............................L.VASL....oE.RL+NGERDIDsLVEpARcRVhpsGELTRsEl-plocAVRRDLEEFAhSYEE................pppDSVFhRVIKESLWQELADITDKTQLEW....REVFQDLsHHG.....VYHSGEVV.GLGNLVCEKCHaHLsl.Y.T.P.-.V.LshCPKCGHDQFpRRP.F.......	0	23	49	77
+7124	PF07296	TraP		TraP protein	Moxon SJ	anon	Pfam-B_18635 (release 10.0)	Family	This family consists of several bacterial conjugative transfer TraP proteins from Escherichia coli and Salmonella typhimurium. TraP appears to play a minor role in conjugation and may interact with TraB, which varies in sequence along with TraP, in order to stabilise the proposed transmembrane complex formed by the tra operon products [1].	25.00	25.00	52.10	53.30	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.34	0.71	-5.35	3	150	2009-01-15 18:05:59	2003-09-15 11:56:11	6	2	115	0	4	90	0	182.40	72	98.69	CHANGED	MANNhlop.ts+AshYsVAuVLRWLaWsVKYAVIaPLATMALlVlLVFRTGsTTPGQpLVKEIspVRQpAPuG.FPVpDCssP....usoVsSPlPspLQEsCsh+ITDAA-YAA-IDQSLoQslhhLWuhLALlYTulAVlhG+pPVR+Ghl+p.tVVsuDosLss.thI.tcsEVhT.csshsGQI++s.....sD+pu+sEGDKNEHT	.........MuNNhSuRQAsHAsRYVVApVLRhLFWCLKYsVILPLATMALMALFVLWKDNTTPGKLLVKEIsFVRQTAPAGQFPVuECh.............hsoSD......S...ss.u...plp.-IC+YRAADAADYVRETDRSLMQLVTALWATLALMYsSlAAhTGKYPV.RPGKMK.ClRVVTADE+L.........KEVYTEDASLPGKIRKC.VYhPDDRTNRNNGDKNEHA........................	0	0	0	2
+7125	PF07297	DPM2		Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)	Moxon SJ	anon	Pfam-B_18649 (release 10.0)	Family	This family consists of several eukaryotic dolichol phosphate-mannose biosynthesis regulatory (DPM2) proteins. Biosynthesis of glycosylphosphatidylinositol and N-glycan precursor is dependent upon a mannosyl donor, dolichol phosphate-mannose (DPM). DPM2, an 84 amino acid membrane protein expressed in the endoplasmic reticulum (ER), makes a complex with DPM1 that is essential for the ER localisation and stable expression of DPM1. Moreover, DPM2 enhances binding of dolichol phosphate, a substrate of DPM synthase. Biosynthesis of DPM in mammalian cells is regulated by DPM2 [1].	25.00	25.00	28.20	28.00	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.87	0.72	-3.70	12	227	2009-09-13 06:50:04	2003-09-15 12:00:32	7	4	200	0	152	198	0	74.20	39	80.80	CHANGED	tsD+lVGhuhlshShhlFsYYThWlllLPFlDssHslHpaFLPRsaAlhlPllhsllhhhhlGsFluhVMlKop+..KKu	.........h..DphlGhhhlhsuhhlFhYYThWsl.lhPF..l....D..s...s..H.slppaF.P..RtaAlhIPlhhhllhhshVGsFluhVhl+spp..Kc.....................	0	36	75	120
+7126	PF07298	NnrU		NnrU protein	Moxon SJ	anon	Pfam-B_18406 (release 10.0)	Family	This family consists of several plant and bacterial NnrU proteins. NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that  NnrU and perhaps NnrT are required for expression of both nirK and nor [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.58	0.71	-4.92	102	551	2012-10-01 22:51:20	2003-09-15 12:54:25	6	2	458	0	223	592	305	193.30	25	85.69	CHANGED	lLlhulhlFhusHhh.h.ssshRsthh.utlGctsa+uhaullSlsulslllhuattAchs....LWsss..shhttlsslLhhlAhlllsuuhh.sp..................IhthsRHPhLhuhtlWAlAHLLsNG-lssllLFGuhhsaAlhshhhhc+R........sts.hs.hhsssuhhs..................shhslshGlllahslhh.hHshL.hGlsP	........................................................................................................hllh.LhlFhs.tHSlhh..tsshR.thhh..thl..G....t..t..t...a+uhY.ullSlsu.lsl..l..lht..atttphs......lWss.......shhphls.hh.Lhh..lu.al..hlhsuhh.hpt.......................................lhphsRHPh.h.lG..h..h..l..W.....A.....h.....uH.hlss.Gs....h....hsl.lhhsuh.hhatlhshh..hcp+.........ttt..ht.......sshh.......................hhhhhhulhhhhhhhh..hH.hl..t.............................................................	0	59	136	172
+7127	PF07299	FBP		Fibronectin-binding protein (FBP)	Moxon SJ	anon	Pfam-B_18450 (release 10.0)	Family	This family consists of several bacterial fibronectin-binding proteins which are thought to be involved in virulence in Listeria species [1,2].	22.70	22.70	22.80	23.30	21.70	22.60	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.37	0.70	-5.00	15	400	2009-01-15 18:05:59	2003-09-15 13:05:05	6	1	377	6	70	289	14	187.30	36	93.28	CHANGED	FIcsaQYNaIKpplppLlsuasosNDcsslpsl+uhst-KIhslFsclssEpcpllcslhslp.s+pcA-+aLpcLp.YVlPFppsospplpKLF+KsKKLKlPshcphDh+phoYLGWNDtGop+KaIlhhp.csKLhGlpGslss..pspKGlCoICs...pco-VuLFhupsK.uss.sGTYs++GNYICtDSppCNcplTslspLccFlccl+	................................hIps.QaNhIKpph..LhpsatosNDttslpslpuhs.-KI.tlF.p.t.............t...p.t.llsplhshp.sptcAEphL.plp.hVhPF.tsos.plpKlF...........KsKK.....LKl.P.s.hpphD.h+choYlGWpD.h.u.o.p.R.K.allshp..cs......+hlGl....p....Gohss.......ph....pKu...l....ColCp...sp...s...pVu..hFhuppK....usu....sG.s.asppGNYICpDu.tCNpphpphphLppFhc.lp.................	0	26	55	66
+7129	PF07301	DUF1453		Protein of unknown function (DUF1453)	Moxon SJ	anon	Pfam-B_18607 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.	21.60	21.60	21.60	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.00	0.71	-4.34	20	613	2009-01-15 18:05:59	2003-09-15 13:44:42	6	1	432	0	59	304	1	143.10	50	92.91	CHANGED	M........hslhSolhAlhMuhhlhhl.RhKAuc+Ps..osKKIILPPl.....F.MSTGALMFl..hPhFRlosh-llEAlhlGhl.FSlhLItTS+FElR.sscIYlKRSKAFsaILlGLLllRlshKhhluspIDhupLuGMFalLAFuMIVPWRIAMalpY+Kl	............h...hlhS.llAlhMushlhhl.RhKA..tp..pPl..stKK.IlLPP.h......F.MuTGA.LMal.......hP.hFRL.Ts.h..EhLEAhhlGLl.FShhLIhTS+FEl+..sscIYhKRSKAFshILIuLL.llRhshKhalS.....s..p..lD.GpLuGMFFLLAFsMIVPWRlAMhhpa+KL.............................	0	17	34	45
+7130	PF07302	AroM		AroM protein	Moxon SJ	anon	Pfam-B_18608 (release 10.0)	Family	This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL [1]. The function of this family is unknown.	23.10	23.10	23.20	29.60	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.31	0.70	-5.01	15	531	2012-10-03 04:39:14	2003-09-15 13:50:37	6	2	525	0	48	185	10	220.50	70	98.21	CHANGED	+lAllTIGQuPRs-VlPplpcals-shclschGhLDuLScpEI.schAPpss-.csLlThLsDGppVplS+pKlpctLQpsIptL-ppGh-lIlLhCTGpFs.sLss+ps.LLEPp+IlssLVsullss.pplGllVPlt-Qhs..hptpKWphltpsshhssAoPah.uopsclhpAuppLttpGADllVLDClGYsppp+chlpcthslPVlLupsLlARl....suELls	.........................................S.LAILTIGlVPMpEVLPLLTEYIDE.-.pIoHHSLLGK.....L...S...REEV..MAE...YAPEsGE.DslLT.LLNDN...QLAH....VSR+KVERDLQuVVEVLDNQGYDVIlLMSTAsIu.SMTARNoIhLEPsRILPPLVuSI..V-c..HQVGVIVPVEEhLs...sQAQKWQl.....L.Q.+sPVaSLuN.PlH....sS....E...Q....clIDAG+ELLscGADVIMLDCLGFHQ.RHRDlLQKpLDVPVLLSNVLIARLAAELL.V...........	0	6	18	33
+7131	PF07303	Occludin_ELL		Occludin homology domain	Vella Briffa B, Bateman A	anon	Pfam-B_18556 (release 10.0)	Domain	This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localises to tight junctions [1], while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA [2]. This shared domain is thought to mediate protein interactions [3].	25.30	25.30	25.80	26.10	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.51	0.72	-3.28	18	504	2009-01-15 18:05:59	2003-09-15 14:23:59	8	8	105	3	247	398	4	98.70	38	19.03	CHANGED	YPP.IsSscpRpcYKp-Fss-apEY+pLpAEl-slsc.+hspL-ppL.cpLsc...sSpcYpslt....cEYp+.lK..KpsssYppKKpRCcYL+sKLsHIKphls-YDc	.................YssIpSt-QRppYKp-Fss-YsEY+pLpAclpslsc.+FpcL-spl.cpLsp.........uopEYp...............plp.plhpEYp+h+............KpsPsYppcKpRCcYL+sKLuHIKphI.t-YDp...............	0	29	55	137
+7132	PF07304	SRA1		Steroid receptor RNA activator (SRA1)	Moxon SJ	anon	Pfam-B_18506 (release 10.0)	Family	This family consists of several hypothetical mammalian steroid receptor RNA activator proteins. SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines. SRA-RNA is a steroid receptor co-activator which acts as a functional RNA and is classified as belonging to the growing family of functional non-coding RNAs. 	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.97	0.71	-4.50	4	239	2009-01-15 18:05:59	2003-09-15 14:28:43	6	16	207	1	163	255	0	157.30	24	18.02	CHANGED	hsPPs.........PsSstsssPP.GpG...PsSup.......lpPssscP-....s-tshcsshhsLcpslpsspsShcpplssDIoRRLplLp-.WtGGKLShsV++RMshLspELpstpWDuADcIHhSLMVDHVsEVSQWMVGVKRLIAEsRpLs.c.ht..pputu............QsS	.....................................................................................................................ssssss..............P........t..s...s..ss...s.t...s.............s....Ps.s.s..................................ht.s..s...st...s.p............spt....l....p..ll.p.s....L.pp....sh.p.......t........s....s....s.s.....h....pK...p........h.......c...Dsp+RLslLF-+.L.s.s.s.c.Lo.ps.s.h.cph.tpLspuLps+c.acsAppIHhslh.s..s..+s...s..EsupWhs..........GVKRLIsht...................ss..............	0	41	81	130
+7133	PF07305	DUF1454		Protein of unknown function (DUF1454)	Moxon SJ	anon	Pfam-B_18833 (release 10.0)	Family	This family consists of several Enterobacterial sequences of around 200 residues in length which are often known as YiiQ proteins. The function of this family is unknown.	25.60	25.60	25.70	75.50	24.30	25.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.31	0.71	-5.22	4	549	2009-09-10 15:53:58	2003-09-15 15:29:10	7	1	541	0	42	161	0	197.90	76	99.52	CHANGED	M...K.hshLahhhhhuLslsssA.cApT.s-T.TssAPYLLsGAPoFD.SISQFRE+FNusNPoLPLNEFRuIsopsD+sNLTRAASKINENLYASTALERGTLKIKSlQhTWLPIQG.PEQKAA+sKA.EYMuAllRsFsPphSpsQSpp+LppLLssGKsKRYaocsEGAlRYlVADsGEKGLTFAlEPIKLALSEoLEG.NK	..............................MKPGCTLFhLLsSAL..Tlo...s.T.A...H.AQ..o....s-o.sTTAPYLLAGAPTFDLSISQFREcFNsQNPoLPLNEFRAIDSSsDKAN.LTRAASKINENLYASTALERGTLKIKSlQhTWLP...IQG....PE.Q...............KA............A........KAKA.EY......MAAlIRTlsPLhTKs...QS...QK...KLQsLLTA.GKsKRYYsET.EGAlRYVVADNGEKGLTFAVEPIKLALSEoLEGhN........	0	1	10	25
+7134	PF07306	DUF1455		Protein of unknown function (DUF1455)	Moxon SJ	anon	Pfam-B_19038 (release 10.0)	Family	This family consists of several hypothetical putative outer membrane proteins which appear to be specific to Anaplasma marginale and Anaplasma ovis.	25.00	25.00	241.90	241.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.57	0.71	-4.09	2	8	2009-01-15 18:05:59	2003-09-15 15:31:47	6	1	4	0	1	7	0	130.00	89	99.62	CHANGED	MSCRAF.L+GlLhFsLLPGSLAT.ARP.LLtVsstsuhtQTsGGG..hsttASsThG+LssAsAsSAspS.tl.uSsVhEsGh.sphhSPAQ..ELhusALQPS.TPSSWVFGRTAhSGVRuFLERTVFLVF	MSCRAFSLKGLLAFTLLPGSLATAARPSLLRVGGEASGQQTSGGGFHAAGGASATRGRLTSASAVSAPQSFGVLGSTVWEDGFLPSVFSPAQ..ELLSAALQPSPTPSSWVFGRTAISGVRGFLERTVFLVF.	0	0	0	1
+7135	PF07307	HEPPP_synt_1		Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1	Vella Briffa B	anon	Pfam-B_18592 (release 10.0)	Family	This family contains subunit 1 of bacterial heptaprenyl diphosphate synthase (HEPPP synthase) (EC:2.5.1.30) (approximately 230 residues long). The enzyme consists of two subunits, both of which are required for catalysis of heptaprenyl diphosphate synthesis [1].	29.40	29.40	29.70	29.40	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.18	0.70	-4.88	15	387	2009-09-13 14:07:00	2003-09-15 15:36:15	6	2	383	0	41	188	0	175.40	39	77.92	CHANGED	HsYLtcaIstPhlDEDKLhLLashhs-us..lpppct-cYllTsMLVQlALDTH-cVos.tst.sspspKsRQLTVLAGDYYSGLYYpLLScscDIslIRsLApuI+EINEpKIpLYp+pspsl-plhpSVspIESALlp+lu-+Fthsp.WpphsscaLlh+RL.pEpcha.pttsS.lhcsltph....cstsshcslhp-thcclpcthpphlcp	.............................................................................................................................olLhGDhhSuhaYpLLAEhsDlsh.ptlucAIhEINEhK.sL.a....pp.A.h...s...s...h...E.I.pulVpIEohh.hhT...h...sHFtl...................................................................................s...........................................................	0	13	27	33
+7136	PF07308	DUF1456		Protein of unknown function (DUF1456)	Moxon SJ, Yeats C	anon	Yeats C	Domain	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.	21.70	21.70	22.00	21.80	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.99	0.72	-3.94	117	1896	2009-01-15 18:05:59	2003-09-15 15:37:37	8	2	957	0	262	965	68	68.40	41	85.24	CHANGED	NNslL++LRhALslpcschlclhthus..hplo+s-luuhh..+K.........c-cc......sYp.pCsDphLpsFLsGLhhppRG	....NN.lL++lRhAhslps..s..DllcILshss..hclott-lsuhhRK.................c-cc...............sap.cCsDphLptFLpGLhhcpRG...........	0	60	125	200
+7137	PF07309	FlaF		Flagellar protein FlaF	Moxon SJ	anon	Pfam-B_19331 (release 10.0)	Family	This family consists of several bacterial FlaF flagellar proteins. FlaF and FlaG are trans-acting, regulatory factors that modulate flagellin synthesis during flagellum biogenesis [1].	20.60	20.60	21.40	21.60	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.48	0.71	-4.21	50	272	2009-01-15 18:05:59	2003-09-15 15:41:24	6	2	230	0	103	219	28	112.40	32	93.77	CHANGED	M........stpAYupstp.sstosRphEtpsLs+ssppLppup.....spsstshpth......cALhhNR+LWohhtsDlups-NsLPpcLRAsllsluhFlh+copclh..ttp.s..slpsLI-INpsIhsGL	...................ht.tYtcshp..sstss+-pEttlhs+uhshLpsAp......tpsspshpsl......-Alhasp+LWohlhsDLs.ss-NsLPp-LRAsllSlulaVh+cspclh..psps..pshpsLI-IspsItcGL...................	1	30	63	77
+7138	PF07310	PAS_5	DUF1457; 	PAS domain	Vella Briffa B	anon	Pfam-B_18761 (release 10.0)	Domain	This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. This region is is distantly similar to other PAS domains.	20.60	20.60	20.60	21.40	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.50	0.71	-4.62	10	302	2012-10-04 01:10:46	2003-09-15 15:59:54	8	1	218	0	104	274	26	135.90	26	68.99	CHANGED	M+psSotplFuYWsclRsucs....sP+RuDI-Pucl+sLLuDsFlLps-usGshsFRLAGTRLCsLhGc-L+spsFsuLas.ssRpclscllssVhccsssslsslsutspsGss.lchElLLLPLpscsssssphLGlLs	.............................................shhtlhsYWpp.l.pt..s.cs..........hPtRps.lDPt.cl.t.p...hLssl..F...lL..E......p..p.....s.t.....u..p...h.ph.RL....A..GT+lssla....Gp.-l+...Ghph.ss...l..astp..s.........p.t..t.l.t..chlps.Vhppt.ssshhths......u.h....shsu....pt..lph-h...lLLP.Lt.sssst..phlGsh.s.............................................................	0	44	69	80
+7139	PF07311	Dodecin	DUF1458;	Dodecin	Moxon SJ, Anantharaman V	anon	Pfam-B_18876 (release 10.0)	Family	Dodecin is a flavin-binding protein [1],found in several bacteria and  few archaea and represents a stand-alone version of the SHS2  domain [2]. It most closely resembles the SHS2 domains of FtsA and  Rpb7p, and represents a single domain small-molecule binding form[1].	21.00	21.00	21.10	27.40	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.73	0.72	-3.94	80	611	2012-10-02 11:08:51	2003-09-15 16:03:34	7	2	529	137	255	516	39	65.40	41	90.96	CHANGED	+lYKhlEllGoSspSh--AlpsAlscAu+Tl+slcWhEVtEh+uclcs.G+VscaQVslKVuFcl-s	......plYKllEllGoSspSh--AIpsAls+Au.....cTl+slcWFEVs-hRGclcs.GclsaaQVslKVGF+l-........	0	69	170	227
+7140	PF07312	DUF1459		Protein of unknown function (DUF1459)	Moxon SJ	anon	Pfam-B_18877 (release 10.0)	Family	This family consists of several hypothetical Caenorhabditis elegans proteins of around 85 residues in length. The function of this family is unknown.	20.80	20.80	21.00	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.06	0.72	-4.06	2	33	2009-01-15 18:05:59	2003-09-15 16:05:31	6	1	5	0	33	26	0	81.00	47	98.45	CHANGED	MFQKohIVhhhALFCISSsQVlYoPEVVuSPYYYuuuPVA.SAYPYAYAYGAsAYPTAaYGWGSNKGQQA.uSA.PTQKLTNNQ	.........MFpKshh.sl..hls.h.F.sl.uSsQllao.PphVsu..PYYYAu.ussu..AYP.sYu..Y.u..AAAYPos.auWGSNKsp.p..u..s.u.sA...PTpp..LsNN..................	0	8	16	33
+7141	PF07313	DUF1460		Protein of unknown function (DUF1460)	Moxon SJ	anon	Pfam-B_18925 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.	21.30	21.30	21.40	21.40	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.34	0.70	-5.14	25	430	2012-10-10 12:56:15	2003-09-15 16:07:39	7	5	420	3	68	330	60	209.60	41	72.81	CHANGED	tlSptFLGTPYtAspLhGussss..EpLVlcFcGlDCFTalDYVtALp+uss......pssFlcsLhchRYtsGcl.sFhsR+HFFo.DWstssspt..scDlTsplSs...........thlohsKpLNp............Ks-GspalsGLslhcRsl.........sYIPustl........sppVlspL+oGDaIGIYoph........sGLDVTHsGlhltsssu....shhRNASStpss.pVVDsPFh-YlpspP...GI	.....................................................................p.lSptFLGTPYpA....sTLhtsssts..EtLVlNFsGlDCFTalDYV.ALupuss...........ppsFhcsLtphRYts.Gcl...uYhsR+HFFo.DWhsssspp..AcDlT.s...plSs..............phlshsKpLNp..................................................................K.s-GuEalsuLulh.Rpl.............sYIPu..ctI.........................spp..V.h..sp..L+sGDhIGlYosh.................................................sGL.DV...oHlGIs..lp.ccsp.........lhhRNASSlttp...+.VV..D..pP..Fh.-Yh+spP.....GIl.......................	0	15	36	58
+7142	PF07314	DUF1461		Protein of unknown function (DUF1461)	Vella Briffa B	anon	Pfam-B_18854 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. These are possibly integral membrane proteins.	24.00	24.00	24.20	24.70	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.36	0.71	-4.54	40	875	2009-01-15 18:05:59	2003-09-15 16:09:30	6	1	849	0	104	563	21	180.00	35	82.83	CHANGED	h+.......p.h....hslhhhlhlluhulhhslhht..h.hY.hplchhplschss............hshsplhpNaspLhsYLssshppt.Lphssh.sSssG..........hhHFt-VKpLFhhshhlh.lhsllhhhhhhhhhhpcpphhhhh.pshhl..hh......llPlllhhhh.hlsF-paFshFHplhF.sNshWlFDPspDPlIphLPEpFF	............................................................................................hhht........hhhhs.hlhll.ululhlTIhht..a.h.Y.h-IpaLsls.p..h.l.h..........................ls.ps.lhpNaph.L..hsYLssPapph.LphPcF..sSssG..........................ltHFt-VKpLFhls.hVh...l.l...sl...sh..h..ha..l..p..hl..hK...+.ph.....l...th.hh......+.....shhh..hh.............llPl..h.lulhh..hlsF-pFFslFHpllF.ssDsWLFDPspDPlIhlLPEpFF............	0	37	66	84
+7143	PF07315	DUF1462		Protein of unknown function (DUF1462)	Moxon SJ	anon	Pfam-B_19094 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.	25.00	25.00	32.90	109.50	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.14	0.72	-4.02	18	399	2009-01-15 18:05:59	2003-09-15 16:17:21	6	1	399	1	35	144	0	94.40	59	87.33	CHANGED	sVYGA-slCASCVNhPSSK-TaEWLpAALpRKYPsp..sFchpYIDIp.pPs-s..-cpp.caup+Ih-DEhFYPLVllsDElVuEGNPpLKsIapphE	.hVYGA-VICASCVNAPoSK-TY-WLQshLtRKYPs...sFpasYIDIpc-s-s..-.cchpFhERI.pDELFYPLlshNDEhVA-G..phKpIhchI-.	0	9	20	29
+7144	PF07316	DUF1463		Protein of unknown function (DUF1463)	Moxon SJ	anon	Pfam-B_19113 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 140 residues in length. Members of this family seem to be found exclusively in Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	25.00	25.00	25.50	57.20	18.90	17.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-4.59	2	115	2009-09-10 14:48:10	2003-09-15 16:19:18	6	1	27	0	9	71	0	135.40	73	98.69	CHANGED	hpaYsLc.laFShsss.lcoGpLEhooEPsshAhhSoED+shPl.ShRDP+TlsalFslEVohGShDYhLLTcLSsEQFYp.sV.KpcKhhcLsFNDphuhKIISN.AhFsE.PoRpYSA-s-pVpFpI+AINCphpKss	.....MQFYDLREVYFSIGG.sQLHSGKLELTSEPTTRAVlSoEDKGhPVISLRDPKTITYlFNIEVTLGSaDYILLTELSDEQFYNMDVpKpDKMLDLsFNDRIATKIISNYAIFTEEPSRSYSAEAEKVoFEIRAINCQKoKPN.....	0	5	5	5
+7145	PF07317	YcgR		Flagellar regulator YcgR	Moxon SJ	anon	Pfam-B_19142 (release 10.0)	Domain	This domain is found N terminal to Pfam:PF07238.  Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias [3].	21.10	21.10	21.30	21.10	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.02	0.72	-4.30	7	656	2009-01-15 18:05:59	2003-09-15 16:24:08	7	2	640	2	95	297	19	105.70	50	43.27	CHANGED	pFlhps.htIsshLR-LpKpps.lplp.tspGp..hlS+ILslsPppt.hlhDaGutEp-NptsLputplshlspspGsKlEFsssplppscapshPAFpstlPppLahl	..........QFLKpNPLAlLGVLRDLpKsslPLRlS.Ws.sGQ...hISKILslsP-K..Lll...DaGSQsc-Nh..AVL+Apc.lsIsA.ETQGAKVEFTl.p.Q.L.pp.u.EY.p.LPAFIT.s.PsoLWFV...........	0	9	42	68
+7146	PF07318	DUF1464		Protein of unknown function (DUF1464)	Moxon SJ	anon	Pfam-B_19143 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of around 350 residues in length. The function of this family is unknown.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.07	0.70	-5.63	11	65	2012-10-02 23:34:14	2003-09-15 16:32:55	7	1	62	0	43	226	2	317.30	32	93.36	CHANGED	GIDPGTsSaDlsul--..GpVhhctslPTspVtcsPthllchlp-s.....ss-llAuPSGYGLPlh+sp-ls-.....c-IhLhTLsssuctu.....hG......LRshlp.h.uu+sl....ssahlPGVIHLsoVPsaRKlN+IDhGTADKlAosshulhp.sc.....Ycsh....sFILVElGtuFoAslAVpsGpIVDGhGGTh.hsG..ahuuGhhDGElAYLhu....plsKphlFpGGht.hss.......................sapthhE.lhKslsshhuoh.csc.....IIlSGRhtphs-htcclct+htch...........h..t..t.sKEuApGuAlIAsuluGGha+cll-hLtl.cSuGTslDal+L	..............................................................................................................................................................GlDPGTc..Shslhhl--..Gplhh..h.......plsop.V....t.cs..shh.l......lchlpch...............ps-hlshPSGaGl.P..ltp.h.pclsc.......c-lh.l..hTlhcs.tphs........hG......Lpchlp.h..tppph....s..sahI.PuVI..c.LsoVP.t...aRKhNpID...hGTA.DKlAs..sshuh.t..pthtl.apps......sFIllEhGhsasuslsVcsG+IVD...G...h..G...G.T.h......h....s......G...h...h...s.G......s..l...D....u....E...l..........A.Yhl...s..............chs..K...ppl......F.....p.....u.....G.h..hst.................t.............t...t..........shcthhE.ll+tVs...sh.h.s.s.h...chp.....Il.l.SG+h.t..p.....-htcchcpphtth..........h............sKE.AA..GuAhIAsulsGGha+chlphl...cupGosl-alp..............................................................................................................................	1	13	21	34
+7147	PF07319	DnaI_N		Primosomal protein DnaI N-terminus	Vella Briffa B	anon	Pfam-B_18931 (release 10.0)	Family	This family represents the N-terminus (approximately 120 residues) of bacterial primosomal DnaI proteins, although one family member appears to be of viral origin. DnaI is one of the components of the Bacillus subtilis replication restart primosome, and is required for the DnaB75-dependent loading of the DnaC helicase [1].	20.20	20.20	20.30	21.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.23	0.72	-3.74	37	1017	2009-01-15 18:05:59	2003-09-15 16:51:55	6	3	1013	1	99	468	1	91.90	35	30.28	CHANGED	MEslscslpc.hhpppshppchpplhppllsDs-VpuFlpp+ptcLopchIp+uhsKLaEalppppchpt....tsssslhpGYpPpLslspthIDVsY	........................MEsltphlpc...ps..p.c.....a.....t.....pchpc.l.h.pclhpDPDVpsFlppct.cLTsp.Ip+SlsKl.EYlsp+c+att....sDss.lscGYpPpLslspshlDlpY...............	0	22	49	74
+7149	PF07321	YscO		Type III secretion protein YscO	Vella Briffa B	anon	Pfam-B_19036 (release 10.0)	Family	This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis [1].	27.50	27.50	29.10	28.80	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.92	0.71	-4.39	12	104	2009-09-13 06:09:03	2003-09-15 17:16:14	7	1	98	0	19	64	2	149.40	38	69.50	CHANGED	M....lppLhcIKphRt-cApptltpQp.tlssA+tcpppAppshpDa+.WRhpEEpRLauphptphlth+-l-chp....ppluhLR-ppApLtpplscttpplctEpptLppppptlppsp+ppEKhsELtcppps-ttt.pphpEEhE.EEFtp.......ph	.....M.lcpLhclKplRh-RAE+AlppQphplpsAttcppcApps.pDY+.WRhcEEpRLFsptpspslsp+-LEpap....ppluhLRE+EApLEpcsAchtcpLcpERccLppspctlppA++pppKFhELtcppps-ptsppchpEEtEtEEFhphp.......	0	7	9	14
+7150	PF07322	Seadorna_Vp10		Seadornavirus Vp10	Moxon SJ	anon	Pfam-B_18930 (release 10.0)	Family	This family consists of several Seadornavirus Vp10 proteins found in the Banna and Kadipiro viruses. Members of this family are typically around 240 residues in length. The function of this family is unknown.	25.00	25.00	42.20	41.80	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.74	0.70	-5.11	2	12	2009-09-21 14:23:59	2003-09-16 09:38:08	6	1	4	0	0	12	0	228.30	59	92.13	CHANGED	MDVLSKuSLKELLAHLE+TPLEEAlSY+IGTlPYQNVLIsRNEYYNQ.YPDsTSLIDGVuREGQRNVNGLIMSIISYVVSGSGHYIPNIGahLLRRSILDILTKHDTGLsTNNlNYslIARNLTVSKMNCEQRKRMLICFKLLAYKDGN.NDYEhYLNQNIsLKQIAPNFIPGDMRTVhpNpDpLuIVGIPAYRLTQSTELSIRDDNAKSYKlGYVDWYNSNSFLRERs-FNLIpLKDRD.	......LSKSSLKELLAHLE+TPLEEAISYKIG.TlPYQNVLISRsEaYNQLYPDsTSLIDGVuREGpRNl.GLIMSIISYVVSGSGHYIPNlGhhLLRRSILDlLT++DTGLsTNNlNYslIARsLTVsKMNCEQRKRMLICFKLLAYKDGN.sDY-sYLNQNloLKQIAPsFIPsDMRTVlSNsDpLSIVGIPsYRLTQSTELSIRDDNAKSYKlGYVDWYNSNuFLRERN-FNLhpLKDRs.h......................	0	0	0	0
+7151	PF07323	DUF1465		Protein of unknown function (DUF1465)	Moxon SJ	anon	Pfam-B_19346 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	25.00	25.00	28.70	72.80	22.20	20.50	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.81	0.71	-4.66	26	190	2009-01-15 18:05:59	2003-09-16 09:55:55	7	1	189	2	72	161	18	157.20	49	90.36	CHANGED	lphucphstSphFpsLapEGMsLVEETAuYLD.....GtGRspu+sLsRpu....ulsYAsESMRLTTRLMQlASWLLlpRAspcGEMotpQsppEKs+lphssss.....sssshscLP.thpcLltRSpcLptRltRLDcplhst.ssssttt......sPVssQlshLcs.....AF	.......h.phuc+hshSssFcslYtEGMsLVEEsAuYLD.........GcGRp-A+sLs.RsA............uhhYAuESMRLTTRLMQlASWLLLQRAs+pGEMTcsQssuEKs+V+Lcsss..hspsusuas-LP.sht-LlcRShRLQsRVp+lDcclast.s.shpts.....tNPVstQlshL+sAF.........	0	20	42	52
+7152	PF07324	DGCR6		DiGeorge syndrome critical region 6 (DGCR6) protein	Vella Briffa B	anon	Pfam-B_19101 (release 10.0)	Family	This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome [1]. Also found in this family is the Drosophila melanogaster gonadal protein gdl.	23.30	23.30	23.90	24.90	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.26	0.71	-4.83	8	130	2009-01-15 18:05:59	2003-09-16 10:42:51	6	3	87	0	75	129	1	160.30	45	79.11	CHANGED	Mpca.usspt.........hs-pspQ.......QERHYaLLS-LQsLVK-LPSuaQQRlSYosLoDLAhALLDGTVFEIVQGLLEIQHLTEKNLYNQRhKLcsEH+sL+Q-Lt+KHK-ApQ..sC+sHNLulLKssQp+EhEulEpRl+-EQphMDcKIVLELDQKVhDQQSTLEKAGVPGFYlTsNPQElplQMNLLELIhKLQQhp..ssK	..................................................................................Qp+hY.Llp.tLpphhpcL.PpphQpRl.uYshLosLA.sLlss.olF-IVpuLhElQHlTE+pLhppRhplpscap..........h.tpth.hpKhp-spp......t..sH..tLsllpttpp+chc...t...hp.phc-E.p.hDpKIllELDp..KVsDQQSTLEKAGVsGFYVTsNPpElplQMpLL-hI.h+Lppht....................	0	26	32	53
+7153	PF07325	Curto_V2		Curtovirus V2 protein	Moxon SJ	anon	Pfam-B_19350 (release 10.0)	Family	This family consists of several Curtovirus V2 proteins. The exact function of V2 is unclear but it is known that the protein is required for a successful host infection process [1].	25.00	25.00	147.90	147.80	21.90	20.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.48	2	21	2009-01-15 18:05:59	2003-09-16 10:53:44	6	1	17	\N	0	27	0	122.70	76	100.00	CHANGED	MGPFpVsQFPcNYPAhLAVSTSCFhRYNKWCILGI+pElEuLTLEEGEsFLtFQKEVKKLL+hKssFpRKCpLYEcIYKKYl.ssPEcKGp.spshsEEEED.ataEcIPMEEsCspcpssElcDV	MGPFRVDQFPDNYPAFLAVSTSCFLRYN+WCILGIHQEI.EsLTLEEGEVFLQFQKEVKKLLRhKVNF+RKCuLYEEIYKKYVtNVsEKKGE.SSKCVA.EEEE.DhY-..aEEIPMEEsCsKcQc.EVcDV..	0	0	0	0
+7154	PF07326	DUF1466		Protein of unknown function (DUF1466)	Moxon SJ	anon	Pfam-B_19433 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins of around 240 residues in length.	25.00	25.00	31.50	31.00	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.57	0.70	-5.06	2	48	2009-01-15 18:05:59	2003-09-16 11:36:18	6	2	29	0	22	46	0	208.10	54	95.22	CHANGED	MASpWQsMtTSVRRRSL.+pEQLEcpc.hpsssuH.ET..GsLGSLCRQFQRRLPLRAVsLsLtsGPSWKRLEoPEPtQQGL..AARSAKSALGAhSQRIQESCQuGTKWLhETQVKsRR.KRGAQKspGSPs.SLSQKsTRLs.....+ustDsh.ttHhRLSspMGsHsH.hpR.RREAAhRSPhSSTEPLCSPSESDSDLEPsGAGIQHLQKLSQcLDcAIhAEEptph.....hp	................................MASpWQuhtsSV..+RRSLpcpEQLE-pcthpPs..suH.ETSsGALGSLCRQFQRRLPLRAVsLN.LssGPSWKRLEoPEPtQQGLQAAARSAKsALGAhSQRIQESCQ.SGTKWLVE...T..QVK..ARR...R.+R..GAQKsuuoPs+S....L........Sp+...ST..RLou..s..sss...p...ust.....s.....shppp......t+pLSs....hG.scApP..hRRSRR.-AAh.RSPYSS....oEPLC......SP.p...ESDSDLEPVGuGIQ+LQKLSQcLD-AIhsEEptph.s.............................	0	1	2	6
+7155	PF07327	Neuroparsin		Neuroparsin	Moxon SJ	anon	Pfam-B_19487 (release 10.0)	Family	This family consists of several locust specific neuroparsin proteins. Neuroparsins are produced by the A1 type of protocerebral median neurosecretory cells of the PI-CC system and display pleiotropic activities: inhibition of the effect of juvenile hormone, stimulation of fluid reabsorption of isolated recta, induction of an increase in hemolymph lipid and trehalose levels, and neurotrophic effects [1].	21.40	21.40	22.40	26.20	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.59	0.72	-3.79	4	14	2009-09-11 14:17:53	2003-09-16 11:54:31	6	1	11	0	5	23	0	102.50	37	87.08	CHANGED	MKPAAALAAATLLIAVILFHRAEANPISRSCEGANCVVDLTRCEYGEVTDFFGRKVCAKGPG-+Css....atpCGsGhcCpsthCoGCSl+TLQCa.h-uhs.Spp	.........................................hhhlhhhlhLh.pps.tt..p....Rpsc..sstCs...s...Dh.s+CcYG..Vp.DhCGpcsCAKGPG-+CGG.....phaGhCG-GLhC.sCs..+CsGCSlcolpCa...........................	0	2	3	5
+7156	PF07328	VirD1		T-DNA border endonuclease VirD1	Moxon SJ	anon	Pfam-B_19558 (release 10.0)	Family	This family consists of several T-DNA border endonuclease VirD1 proteins which appear to be found exclusively in Agrobacterium species. Agrobacterium, a plant pathogen, is capable to stably transform the plant cell with a segment of its own DNA called T-DNA (transferred DNA). This process depends, among others, on the specialised bacterial virulence proteins VirD1 and VirD2 that excise the T-DNA from its adjacent sequences. VirD1 is thought to interact with VirD2 in this process [1].	20.30	20.30	20.90	48.20	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-4.40	2	14	2009-01-15 18:05:59	2003-09-16 11:58:56	6	1	8	0	5	13	1	144.40	61	98.06	CHANGED	MSptoRsTSS-hAlNQ+cslpVEGFKVVSsRLRSAEYEoFSaQARLLGLSDSMAIRVAVRRIGGFLEIDAcTRc+MEAILQSIGhLSSNluhLLSAYAEsPp.DLEAlRsERIAFGcuFAsLDGLLRSILSVSRRRIDGCSLLKsAL	........MSpts+sTSSDh.lsp+cuspl...EGFKVVSsRLRSAEYEoFScQARLLGLSDSMAIRVAVRRIGGFLEIDA-TRpcMEAILpSIGsLSoNIusLLsAYAEsPpsDLEAlpAERhAFGcuFAcLDGLLRSILSVSRRRIDGCShL+-AL..	1	1	4	4
+7158	PF07330	DUF1467		Protein of unknown function (DUF1467)	Moxon SJ	anon	Pfam-B_19588 (release 10.0)	Family	This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.	23.00	23.00	23.40	33.30	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.86	0.72	-4.20	55	237	2009-09-11 13:34:12	2003-09-16 12:52:07	7	1	236	0	85	195	673	83.90	36	91.74	CHANGED	MulsoulslYhllWahshFslLPhtl.+oQsEs.ucll.....sGTcsGAPsphpht+KslhTTllusllaulhhhlhhsGhlolccls....phh	.....MslhoulAlYhllWWhsLFslLPhGl.RTQsEp.s-ls......GTssuAPsps+ltRthlhTTllusllaslhhhlhhsuhlslccls...h.........	0	22	51	62
+7159	PF07331	TctB	DUF1468;	Tripartite tricarboxylate transporter TctB family	Moxon SJ	anon	Pfam-B_19347 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	27.00	27.00	27.00	27.20	26.90	26.70	hmmbuild  --amino -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.82	0.71	-4.53	199	1745	2009-10-20 16:26:54	2003-09-16 13:02:42	6	4	965	0	571	1522	1240	141.90	21	86.17	CHANGED	tt-hhsullh..hslGhhhhhtu.hshshssst.....thGPuhFPhhluhlLhllGhhlhlpuhht.............................ttstthhsths........h+........slhhllsul..lhaslll....................p..........slGhllush............lhh.hhsshshs.........pt....phhtsl...llul......slsshs..ahlF...shhLslsL.P	........................................................................t..phhhuh.l.h...lhlu.hh.hh.htu....hph....ththsh........shG.Pt.h.aPh.hluslh.hl.h....ul.h.ll.lp.shh............................................tpssshhtp.hs...................h.p..............p.l.hhhl...shh......lhas.h.h.h....................p.........hlG..Fhluos................lhh.hsh.h.h.h.hu......................tp..........ph.hhsh.....lhuh....shslhh...ahlF...sthLslsLP...........	0	158	355	476
+7160	PF07332	DUF1469		Protein of unknown function (DUF1469)	Moxon SJ, Finn RD, Sammut SJ, Bateman A	anon	Pfam-B_19352 (release 10.0) & COG5393	Domain	This family consists of several hypothetical bacterial proteins of around 140 residues in length. The function of this family is unknown.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.46	0.71	-4.38	97	1760	2009-01-15 18:05:59	2003-09-16 13:06:22	6	4	1530	0	487	1143	145	115.40	24	80.40	CHANGED	lspLlschssplspLlcsElcLA+sElpccsppsutusuhlsuAullshhulhhLhhslshuL..shh...........s.h...hAhLl....VuslhhllAullshhGhpclc...tshsPpcThcplccDhphlcpp	.................................h....hpclss.hsphlcsclcLAtsE...lpc...cttp.hhp...hlhhhuhshlhuhhuLhs....L.hhhl.h.h.ul..phh..h....................sAhlh.ssslhlll.Ahlhulhshpp.h+...psph.ppThcpltpDhphlct.t...........................................	0	139	307	413
+7161	PF07333	SLR1-BP		S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP)	Moxon SJ	anon	Pfam-B_19392 (release 10.0)	Family	This family consists of a number of cysteine rich SLR1 binding pollen coat like proteins. Adhesion of pollen grains to the stigmatic surface is a critical step during sexual reproduction in plants. In Brassica, S locus-related glycoprotein 1 (SLR1), a stigma-specific protein belonging to the S gene family of proteins, has been shown to be involved in this step. SLR1-BP specifically binds SLR1 with high affinity. The SLR1-BP gene is specifically expressed in pollen at late stages of development and is a member of the class A pollen coat protein (PCP) family, which includes PCP-A1, an SLG (S locus glycoprotein)-binding protein [1].	22.70	22.70	22.80	22.90	22.60	22.60	hmmbuild  --amino -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.59	0.72	-3.74	37	134	2012-10-01 23:31:40	2003-09-16 13:35:05	7	1	17	0	112	138	0	55.50	27	69.59	CHANGED	sppppupp.....Cpphl.........sspCssspCpshChpp....h+Gs...GpChs........ttphtChCtY.C	........t.....ttth....Cpphl.........sssCs..hspCpstCtpc....apGs...GpChs...............ttthpChCpY.C.......	0	43	57	62
+7162	PF07334	IFP_35_N		Interferon-induced 35 kDa protein (IFP 35) N-terminus	Vella Briffa B	anon	Pfam-B_17864 (release 10.0)	Family	This family represents the N-terminus of interferon-induced 35 kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an alpha helical configuration [1]. This family also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.	22.90	22.90	23.00	25.10	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.45	0.72	-4.01	6	78	2009-01-15 18:05:59	2003-09-16 13:47:53	8	3	29	0	36	73	0	71.60	41	25.89	CHANGED	LltEIpcENhpLKcEIQKLEsELQpssRE.QI+EDlPcsKlKFoSsEsP....EsssQhuslSpShQss.KlsYELQKGQ	.........lptlpcEphpLKpclQ........ELQp....tp+...-..l+c......DlP..csKlpFsssEsP....tpspQhpslupShpsss+lsY.LpcGp.....	0	2	3	9
+7163	PF07335	Glyco_hydro_75	Chitosanase;	Fungal chitosanase of glycosyl hydrolase group 75	Moxon SJ	anon	Pfam-B_19431 (release 10.0)	Family	This family consists of several fungal chitosanase proteins. Chitin, xylan, 6-O-sulphated chitosan and O-carboxymethyl chitin are indigestible by chitosanase [1]. EC:3.2.1.132. The mechanism is likely to be inverting, and the probable catalytic neutrophile base is Asp, with the probable catalytic proton donor being Glu. (see the Chitosanase web-page from CAZY).	21.00	21.00	29.00	26.50	20.80	20.50	hmmbuild  --amino -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.23	0.71	-4.34	43	185	2009-01-15 18:05:59	2003-09-16 13:51:45	6	12	121	0	107	196	0	160.70	34	51.35	CHANGED	MDlDCDGss........................hpC................p..sss.shQspTuFp...............................................h....shpsLsApthPYlVls................sshas.pspG..lpstslsAVls..ss+lhYGlhGDo..........sus....shlGEASlulAcsh..sp.......shsGssG..psss...DVh.......................Y.................IsFsGsc..ss.Pstth....spshpshppsl..pshG-cLlspl	.......................................................................................MDlDCDGts........................................................sspC....................................s..sss.shQspTuFp...................................................t.shpsLsAshhPYVVhss...................sshasspptG..lcshSVsAVVs....ss+l.............hYGl..hGDT..........NGs.............shhGEASluhApsC.....sp.........sh.sGssG.....psss....DVl.......................Y...................IsFsGsc...uV.Putst....spshtp.tpol..tthGsphlt..h.................................................................	0	19	51	85
+7164	PF07336	DUF1470		Protein of unknown function (DUF1470)	Moxon SJ	anon	Pfam-B_19432 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. Members of this family are found in Streptomyces, Rhizobium, Ralstonia, Agrobacterium and Bradyrhizobium species. The function of this family is unknown.	23.40	23.40	23.40	23.50	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.68	0.71	-3.82	101	865	2009-01-15 18:05:59	2003-09-16 13:55:16	6	4	373	1	337	872	14	127.80	18	66.25	CHANGED	usphuLDhlNTsshts.......stsh-tLsss..ssltsWlttpshhsssssstttt...............httst...sLR-...slpplhput...tsspt...........slstlNphltpss.stspLst........t..ththphttsssss..tshlss...lAt.shspllsssph	...............................................phsl-hlNThh..h.t...........tt.hDhLsss........pslttWh.....p....tt..s.hsss..ttssttth..................................................tth+.......plR-...slctlhput..........sstt.................slsh.lNphltpss..stsplst......................ht.ht.....h.h.ssss..sh...........sth..lus...lAt..shhpllst...h........................................	0	130	251	303
+7165	PF07337	CagY_M		DC-EC Repeat	Yeats C	anon	Yeats C	Repeat	This repeat is found in the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells ([1]). It forms part of a surface needle structure, and this repeat may form an alpha-helical rod structure ([1]). A conserved -DC- and -EC- can be seen in regularly spaced in the alignment.	20.70	20.70	21.50	20.70	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.49	0.72	-4.46	13	2220	2009-01-15 18:05:59	2003-09-16 13:58:32	6	49	41	0	30	2236	1	32.50	51	48.99	CHANGED	+AahDClspA+sEpE+p...EC.KLLocpt+chLpc	..+AYhDClspA+sEpE++...EC.KLLosEt+KhLpt.........	0	29	30	30
+7166	PF07338	DUF1471		Protein of unknown function (DUF1471)	Moxon SJ	anon	Pfam-B_19452 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some members of this family are annotated as ydgH precursors and contain two copies of this region, one at the N-terminus and the other at the C-terminus. The function of this family is unknown.	21.40	21.40	21.70	21.90	21.30	21.00	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.39	0.72	-4.32	81	6384	2009-01-15 18:05:59	2003-09-16 14:09:38	8	3	551	5	450	1630	15	55.80	31	59.41	CHANGED	slpshGslossut....so.s-lpptluc+A-ppGAphYhIhptps....ssphcuoAtlY+	..............hp.hG.slSsout....uo.s-hcptluc+AccpGAssYpIsphpp.......sss.....hcuoA.lYK..........	1	15	79	263
+7167	PF07339	DUF1472		Protein of unknown function (DUF1472)	Moxon SJ	anon	Pfam-B_19493 (release 10.0)	Family	This family consists of several Enterobacterial proteins of around 125 residues in length and contains 6 highly conserved cysteine residues. The function of this family is unknown.	19.60	19.60	19.90	20.30	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.56	0.72	-3.70	2	74	2009-01-15 18:05:59	2003-09-16 14:16:46	7	3	48	0	0	59	0	78.20	61	47.89	CHANGED	AWPCGFSshWP.pRVRAVPCLHLSRAGtDARVRFAAAVTRSLLPVCRDFPVVHPLRFRGLTLQLPsAVCVRLRLPLRPVHPRLIARLLWRHGTARCRthC-	.....................................AWPCGFSVMWP.pRVRAVPCLHLSRAGhDARVRFAAAVTRSLLPVCR..DFPVV+PLRFRGLTLQLPsAVCVRLRLPLR.....PhhP.tL...........................................	0	0	0	0
+7168	PF07340	Herpes_IE1		Cytomegalovirus IE1 protein	Bateman A	anon	Pfam-B_22587 (release 10.0)	Family	Expression from a human cytomegalovirus early promoter (E1.7) has been shown to be activated in trans by the IE2 gene product. Although the IE1 gene product alone had no effect on this early viral promoter, maximal early promoter activity was detected when both IE1 and IE2 gene products were present [1].  The IE1 protein from cytomegalovirus is also known as UL123.	19.60	19.60	19.60	19.60	19.30	18.60	hmmbuild  -o /dev/null HMM SEED	392	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.20	0.70	-6.02	2	150	2009-01-15 18:05:59	2003-09-16 14:24:06	6	2	14	0	0	143	0	212.90	60	59.56	CHANGED	MESSu.KRKMDssNPDEGPSSKlPRPETPVoKAssFLpoMlpKEVNSQLsLGDPLFP-luE-sLKoFEcVTc-CsENPtKDlLtELVKQIKVRVDhVRp+lKpHMLpKYTQh-EKFTuAFN.MGGCLQsALDILDKVpEPFE-MKCIGlTMQsMYENYlVsE-pR-hWhtClK-LHDVuKsAAsKLGsALpAKApAKK-ELpRKMhYhsh+plEFFTKNSAFPKTTNGsStAhAALQsh.QCSP-ElhsaAQ+IhKhLDEERDKVLhHIDpIFMDILTTCVETMsNEYKVTSDAsMMTMYGuISLLoEFCRVLSCYlLEEoSVMlA+pP.ITK.-llSsMpRRIpEICM+VFAQYlLGsDPLRVCSPSV-DLRAIAEESDE-EAIsAashAT	.................................ssPt.GsS.s........K.s+.-s..h..p.pAstaLpphLttEhp..s.lsLGDPLF...s.hs.pp..hcohEplhppt.pss..........................................................................TMQsMYENYIVPEDK..REMWMACIKELasVoKGAANKLGGALpAKARAKKDELcRKMhYMCYRNlEFFTKNSAFPKTTNGCSQAMAALQNLPQ.C.S.P.DEIMs...........................................................................................................................................................................................	2	0	0	0
+7169	PF07341	DUF1473		Protein of unknown function (DUF1473)	Moxon SJ	anon	Pfam-B_19856 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be found exclusively in Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	25.00	25.00	38.10	38.00	21.20	18.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.99	0.71	-4.69	2	128	2009-01-15 18:05:59	2003-09-16 14:28:22	6	1	27	0	8	89	0	145.10	72	98.82	CHANGED	MRYKhKILT+sKTacYsLKslPhYEWDpVLGF.sppDt.l.KLN-lphL+EITpLMIS.tFLDEFY.ILsppRca.phYK.hLshIlahsQashFph.pshKKPuLVYlppapspsGDalpaDYIsEpapY-hlhTS.pS.s.Np............pEhVsc	...MRYKMKILTKNKTYEYPL+VLPVYEWD+VLGF.NQSDA.lhKLNEVKYLREITSLMISPKFLDEFYlI.LDpNREFISYYKDYLVAIIYTAQFNTFHlDNDLKKPALVYLSEYENNVGDFVsFDYIN.ENF-YEKVsTSLoSso.NSp-................Lhsh.........	0	5	5	5
+7170	PF07342	DUF1474		Protein of unknown function (DUF1474)	Moxon SJ	anon	Pfam-B_19882 (release 10.0)	Family	This family consists of several bacterial proteins of around 100 residues in length. Members of this family seem to be found exclusively in Staphylococcus aureus. The function of this family is unknown.	21.40	21.40	21.50	56.10	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.40	0.72	-3.78	5	167	2009-01-15 18:05:59	2003-09-16 15:10:26	6	1	114	0	3	77	1	96.30	55	95.33	CHANGED	MNWEIKNLhsDLEVLKEKFEDLKDsHGWHFEEhYsHEPNHsLNKDEhI+EGsSYHERRIHN-QMhDLhHlYhcpFDcIlcKFcEIEKASS-.sFG-cSDDA	.MNWEIKsLMCDlEllK-KlpDlsspHuWFsE-hFs...Ncl.oKcEhIsauhSYhEHRIpN-phh-LhplYLK-FspLIpKF+EIEKASS-..sFu-.SDDA................	0	0	0	3
+7171	PF07343	DUF1475		Protein of unknown function (DUF1475)	Moxon SJ	anon	Pfam-B_19887 (release 10.0)	Family	This family consists of several hypothetical plant proteins of around 250 residues in length. Members of this family seem to be found exclusively in Arabidopsis thaliana. The function of this family is unknown.	21.10	21.10	21.50	21.20	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.06	0.70	-5.03	2	48	2009-01-15 18:05:59	2003-09-16 15:13:07	6	2	25	0	21	46	101	187.80	39	93.19	CHANGED	MAssu.lssh+sVhsshhsLMLuTLVYThlTDG.Ph..R.-lhTPWhVsTllDFYlNlssIusWllYKEssW.uShhWslLLhhFGSlsTCsYlhlpLhclpsptsSpDPh.hLhLR....pGsh.ccKsShVlhuRhlFuhLGshMhusllYTshT.G.PF+h-LLhPWMsshLlsFYIsVhslSVWVsaKESshI.shlWlsLLIshGSlsTsuhIVlQLFplS.hDPlYhVL...Lps+sK.lNu..Gph.	........................................................h.hh+slhsshhhlMlu.sLlYThhT...DG.Ph..R.-lh..T..PWhssTllDFYlNlhslusWlhYKEssa.uuhhWhlhLhhhGShsTssYlh.phhclpsttsspsPh.hlhlR....pss..ppKp...VhhuRhlFuhLGhlMhuslsYTsh..TsG.PF+...h-.....LL..sPWMssoLlDFYIsVhslSVWVsaKESohIsshlWlsLLIshGSlsTsuY.IllQLhplS.tDPlhhVL....................tt.....................	1	9	15	18
+7172	PF07344	Amastin		Amastin surface glycoprotein	Vella Briffa B	anon	Pfam-B_19245 (release 10.0)	Family	This family contains the eukaryotic surface glycoprotein amastin (approximately 180 residues long).In Trypanosoma cruzi, amastin is particularly abundant during the amastigote stage.	23.60	23.60	23.80	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.28	0.71	-4.61	76	430	2012-10-03 00:20:40	2003-09-16 15:13:54	6	2	19	0	67	443	0	156.20	30	75.97	CHANGED	FlAFl........hVLVuT.PlDM..F.Rhpst.......s..psClTLWG..hKpsCpsspYshpssth.atsC....ssRhppF+sApAFAlISIhlauAAhlhGhl....hLhCC..............................................shhRhlCLsLNllGslTlslVWAsMsssYth........-sthC.s..thp..................pth.paGu..................GFuLhlsAWlL-llNIlhL	..............................................hlAFlFVlluT.Pls........F.+sctp.........ss........psClTLWG........hK........pcC.p.s.sp.Y..phshsph.at......pC........s..shhphFRh..ApAFuIISIhlhhuAhlhGhh.....hhh.s.h..............................................psh+..h..hs..hh...LslluhlTs..slVWssMsshYp.............ss.C.s.......thp..........................pth.paGs....................GFsLhVhu...WsLphlshhh.....................................................	0	54	59	67
+7173	PF07345	DUF1476		Domain of unknown function (DUF1476)	Moxon SJ	anon	Pfam-B_19680 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family are found in Bradyrhizobium, Rhizobium, Brucella and Caulobacter species. The function of this family is unknown.	25.00	25.00	25.70	25.60	23.20	22.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.29	0.72	-3.78	53	246	2009-01-15 18:05:59	2003-09-16 15:17:52	6	2	219	2	87	209	311	101.80	49	93.76	CHANGED	M.ToFDDREcAFEsKFAHDpEhpFKApARRNKLLGLWAA-hLGhoGs-A-AYAppVVpADFEEuGD-DVhRKltuDLss.tuht.s-spIRs+MschhspA.ctQl	........................M.TshDDREcAFEpKFAhDpEhcFKAcARRNKLLGLWAA.Ep.LGhsss-A.-AYA+-VVtADFEE....AG....DEDVhRKVpuDLsu.tGlsho-ppIRt+MtphhtpAhpQl..............	0	28	56	65
+7174	PF07346	DUF1477		Protein of unknown function (DUF1477)	Moxon SJ	anon	Pfam-B_19762 (release 10.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 100 resides in length. The function of this family is unknown.	21.60	21.60	84.20	83.90	21.20	19.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.71	0.71	-4.06	19	41	2009-01-15 18:05:59	2003-09-16 15:20:19	6	1	40	0	0	37	0	112.00	31	96.21	CHANGED	M.......................pt.t.phpsutsp...........sltshss......su+phFYphshs....alpph.sssphshsTltslhDtIIphEpslFs+ShVLNhllsFLlspSDGss.lQstl.splLsaLLpKYh	...................h...........th.pstsp...........slsslhs.....psu+phFYplshu....alpphh.hsspssl.TlpshhDtIIphEcslFs+ShlLNhlVsFLlspSDGss.lQstl.splLsaLLpKY................	0	0	0	0
+7175	PF07347	CI-B14_5a		NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)	Vella Briffa B	anon	Pfam-B_19436 (release 10.0)	Family	This family contains the eukaryotic NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) (EC:1.6.5.3). This is approximately 100 residues long, and forms part of a multiprotein complex that resides on the inner mitochondrial membrane. The main function of the complex is the transport of electrons from NADH to ubiquinone, accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space [1].	25.00	25.00	27.60	27.30	19.70	17.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.30	0.72	-4.22	9	115	2009-09-11 15:22:33	2003-09-16 15:42:13	7	1	89	0	77	113	0	95.00	41	80.28	CHANGED	o.hlQ+lRsFLLGR..caphsLRapDtlucRTQPsPpLPcGPuHKLSuNYYspRDuRREVsPPlsl.hpspKtLhAtpsuuht......p+hssPG.psasW-	...........o.hlpplRsah.G+...ptph..tLRap-..lupR..TQPPPpLPsGPuH..KLSsNYYhTRDuRREshPPhll..hss...p.Kt.Ls..us...ps....s.....tp..tss...s...p+ssoPu..hhtW..........................................	0	25	31	55
+7176	PF07348	Syd		Syd protein (SUKH-2)	Vella Briffa B, Zhang D, Aravind L	anon	Pfam-B_19909 (release 10.0)	Family	This family contains a number of bacterial Syd proteins approximately 180 residues long. It has been suggested that Syd is loosely associated with the cytoplasmic surface of the cytoplasmic membrane, and that interaction with SecY may be involved in this membrane association [1]. Operon analysis showed that Syd protein may function as immunity protein in bacterial toxin systems [2].	25.00	25.00	26.00	25.50	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.71	0.71	-4.94	43	745	2012-10-01 20:46:44	2003-09-16 16:03:31	7	2	729	2	81	305	25	173.90	60	95.43	CHANGED	lppALpsFhppYhptappppuphPtsth..s....hsSPCl...........psp-stlhWpPl..........+s.sschsslEcAL-lpLHssIpsFasshauuchtupap......stplpLLQlWsc-DFp+LQcNllGHLlMp++LKpssTlFIussss.-tpllolsNhoGpVhLEphGppp+chLAssLspFLspLpP	.......T.AQAL+sFTsRYCDAWpEcHtSaPlSEELYG....VPSPCIl..........uoo-DAVaWQPQ.........PF.s.u.E.pNlNAVERAhDIslQPsIHsFYTT....QFAGD.MpAQFu......Dh+LTLLQsWSEDDFcRVQENLIGHLVTQKRLKLsPTLFIAThEp.EL-VISVCNLSGEVhpETL.......GT+pRThLAusLAEFLsQLcP..........	0	9	25	51
+7177	PF07349	DUF1478		Protein of unknown function (DUF1478)	Moxon SJ	anon	Pfam-B_20105 (release 10.0)	Family	This family consists of several hypothetical Sapovirus proteins of around 165 residues in length. The function of this family is unknown.	25.00	25.00	25.10	25.10	20.20	18.40	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-10.94	0.71	-4.86	9	46	2009-01-15 18:05:59	2003-09-16 16:04:07	6	2	46	0	0	37	0	144.80	55	98.42	CHANGED	MA.Ps.pspcplsth.hhLT......RLspLsRPHPhLLhLIRNNPMGP+sAW+WLL.LsQSN.MSLpQYuTALQShVLLLGhhsCPRELhhDLa+FIPTLh+Th.IsptCG.uGsssLRssapSLuLssLLusSLLLShHpGLh.R.SshpsCCLTLpLMLA.hsQFh.	.........................MAPs.pspphhsth.hhLT......RLAQhlRPHPhLLhLIRsNPMGPHsAWpWLL.LVQSN.MSL+QYATALQSFVLLLGTTsCPRELh.hDLaRFIPTLT+T.hhshtCG.GGsssLRsshpSLsLushLusSLLLS...thh...ssh.....h...........................	0	0	0	0
+7178	PF07350	DUF1479		Protein of unknown function (DUF1479)	Moxon SJ	anon	Pfam-B_20226 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins, of around 420 residues in length. Members of this family are often known as YbiU. The function of this family is unknown.	19.60	19.60	19.70	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.38	0.70	-5.99	29	709	2012-10-10 13:59:34	2003-09-16 16:07:15	7	6	609	3	194	467	337	392.90	54	91.46	CHANGED	ssL.Ps....papplKppLh...sp.....ctlhtoWc+lltslpcclcplpptGss..slPplsFsDItssphs........sphttpl+cRGssVIRuVhsccpAhpWpp-ltcYlcpN...........sp.htshs..sscPplYplYWSpsQlcARtHPphhtsppFhs.pLWp........st..sspshhshcpslsYADRlRhR.PGss.........................................................................phuLusHlDuGSlERWp-csY..pplYcplFc..GcWE.caDPa-A...spRssupppha.......tususCShFRoFQGWhALSshtPspGTLplhPlsc.uhAYhlLRPhFssss........................................................................sschsGAhPGpu.phssph.HPcLpL.cshlsIPclpsGDhVaWHCDllHuV-stHpGpssSsV......................hYIPusPhstpNstYltcQRcuFlpGpsPPDFstts.................EssatGRss.pc..lsph.....GhpuhGl	............................c....AAIRphKpuLRAplG.D....sQtlFspLscsIAspVsE...Issl...+ApGps...................VhPhlsauDI..t.sGp.lo........spp+tpIKRRGCAVI+GhFPREQALu..WcpshlDYLD+N+FDEh...............h+ustDs.aFGoLu..AS+PpIYslYWSpAQhpARQSccM.s.t.AQsFLN.R.LWp..................hE...pDGKpa.........FsPDhsllYsDRIRR.RPP.GoT.........................................................................SpGLGAHsDSG.uLERWLhPuY...p+VassVFs...Gs..hp....p............YDPWcA...AHRT-VEEash...............csospCSVFRTFQ..................GWTALSD....h.hP........G......pGhLHVlPIPc..AM.AYlLLRP...LhDDVP.........................................................................-D-LCGsAPG....Rs....L....sl....SE.p....W..HPL..Lh.cALoSIPpLEAGDoVWWHCD................VIH....S.Vs......sVc.NtpG.auNV.........................................................MYIPAA.PhCEK.NlAYs++.+sAhpcGsSPsDFPp-D....a.............EosacGRh.TltD..Lshc.....GKRALGh...............................................	0	48	99	165
+7179	PF07351	DUF1480		Protein of unknown function (DUF1480)	Moxon SJ	anon	Pfam-B_20253 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.	25.00	25.00	43.00	42.80	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.65	0.72	-3.99	6	520	2009-09-11 08:41:35	2003-09-16 16:08:45	8	2	509	0	27	99	0	76.60	83	99.24	CHANGED	MsKTsV+IuuFEVDDApLSSss.cs.-pTlSIPCKSDPDLCMQLDGWDEpTSIPAlLDGKcpLLY+pHYD+ppDAWVMRls	.........KTSVRIGAFEIDDuELHGES.PG..-RTLTIPCKSD...PDLCMQLDAWDAETSIPAlLNGEHSVLYRT+YDQQSDAWIMRL.A...	0	1	6	17
+7180	PF07352	Phage_Mu_Gam		Bacteriophage Mu Gam like protein	Moxon SJ	anon	Pfam-B_19455 (release 10.0)	Family	This family consists of bacterial and phage Gam proteins. The gam gene of bacteriophage Mu encodes a protein which protects linear double stranded DNA from exonuclease degradation in vitro and in vivo [1].	24.70	24.70	25.20	28.10	23.90	24.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.71	0.71	-4.68	27	345	2009-01-15 18:05:59	2003-09-16 16:14:02	7	1	306	2	48	280	5	146.00	27	85.80	CHANGED	sh-plshsl+clu-lppchpclcsthscclscIc-thpsph...........cslpsclphlpptlpsascsp+sEhs...ctKohphshGplpaRtppsssth....sh-sllctL.+ph....Gh.pca...........I+scE-lsKcslhppsc.............sspslsGlplppt.-sFtlcs	..................................sh-plshsl+clu-lppcht+lps.......th.......scplscIpcphssph...........csLppclchlppslpsascsp+cEhs...........cpKohshshGclsaRhpssssph.p......sh-sllchL.+ph...........GL...pca............I+s.KE..ElsK-Alhpp.c..............sstslsG.lplhpt.-sFhlcs...................................................................................	0	27	44	47
+7181	PF07353	Uroplakin_II		Uroplakin II	Vella Briffa B	anon	Pfam-B_19993 (release 10.0)	Family	This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension [1].	20.40	21.30	20.40	21.30	19.30	21.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.31	0.71	-4.94	4	38	2009-01-15 18:05:59	2003-09-16 16:33:11	7	1	28	0	18	34	0	160.30	65	91.72	CHANGED	MASsLPVpTLPLILILLAVLuPGAA.DFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVV+SSFVVPPCRGRRELVSVVDSGSGFTVTRLSAYQVTNLsPGTKYYISYLVpKGsSTESSREIPMSTLPR+NMESIGLGMARTGGMVVITVLLSVAMFLLVlGhIlALALGARK	..................................Mss.hPl.TLP.hhLlLLslLuPGuA....-FNISSL...SGLLSPALTESLLVALPPCHLTGGNATLhVRR..ANDSKVVpSuFVVPPCRGRRELVSVVDSGuGFTVTRLSAYQVTNLsPGTKYYlSYhVpKG...suTESSp....ElsMSTLPR+phEoIsL.GM.ARTGGMVVITVLLSVAMFLLVlGhIlALALGs+K..................................................	0	1	2	4
+7182	PF07354	Sp38		Zona-pellucida-binding protein (Sp38)	Vella Briffa B	anon	Pfam-B_19996 (release 10.0)	Family	This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner [1]. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilisation to occur [2].	21.20	21.20	21.20	23.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-11.82	0.70	-5.75	5	94	2009-01-15 18:05:59	2003-09-16 16:59:07	7	5	32	0	42	97	0	231.60	49	65.01	CHANGED	MDh+LuscElVDPsYpWpGPsG+sLoGNSplNITsTGpLlLpcFpESLSGlYTCTLSYKllcApTQEEssl+cpY+FhVYAYREPcYsYQhoVRFTA+uCsutYNssFhRtLKKIL-sLISDLSCcVptPSY+CHSVKhP++GL.sELFlsFQVNPFAPGWcshCsu.StDCEDoTN+plpKA+DRIE-FFRpQsYIL+HpFps.LPsIHYVEGSLQVVhIDsCRPGFG+NplpHssCAuCCVVCSPGTYSPDsuloCpsCsSuLl..YGAKoCP	.............hs.cLpppEllDPoa.WhGPptKhlo........tNsphpITpTGp.LhhpsF.EshSGlYTChLpYKs....T.EEhhhphphcah..laAYREPcY.YQhssRapst.sCtuhaN..F.+hLhpILspLl.DLSCcl...p.cCH.pVch.+tGL.pELFhsF..pVs.shssthtst.sst.shsCE....s.pp..l.p.A+shIEcFFppQs.....lht+php...lPthaal-t...ohQhVhlspChPGaGhN.hhHspCspCC.VlCSPuoasPcsslpC.pCs..osh...h..YGAKsC............	0	4	5	12
+7183	PF07355	GRDB		Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	Vella Briffa B	anon	Pfam-B_19711 (release 10.0)	Family	This family represents a conserved region approximately 350 residues long within the selenoprotein B component of the bacterial glycine, sarcosine and betaine reductase complexes.	19.40	19.40	20.00	19.70	19.20	19.30	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.07	0.70	-5.52	12	440	2009-01-15 18:05:59	2003-09-16 17:22:43	7	2	262	0	72	365	148	241.10	30	90.78	CHANGED	Mt.hKlVHYINQFFAGlGGE-KADhtPclt-u..sGsuhtLsthlcscAElltTVICGDSYas..ENh-cAppplLchlcphpPDlhlAGPAFNAGRYGsACGsIsKhVp-cLsIPulTuMYhENPGs-haKKslYllpTusSAAuMRculPthAcLAhKlhKGE.cIGsPpcEGYhsRGIRhNaFtE-R..GucRAV-MLlKKLpGEpFpTEaPMPsFDRVsPssAl+DlSKAKIALVTSGGIVPKGNPD+IESSSAS+YGcYDIsGhccLostsaETAHGGYDPsaANtDPsRVlPVDVLR-hEKEGhIGcLHchFYoTVGNGTuVAsuKpaupEhstcLhpsGVDAVILTST	...................................................................+hlhhlsp..uthGu--pAph..thcpt..hGsuh.h....h.t.t.....hclhsTlhCGDpah...pp.-p.s.tphhthhpphpsDhhlsGPuhphspaG.hsutlst...pthslPsl..suM..E.N.s.u..h.phahp..p..h.Ilp.h.tps.uhshppsh.thst.hs.thhp.tc.thh.....................................................................h..t.htphplAlhTsuG.l.h.....h.t...t.......cp.....s.st.pat.h.h.......t..............t.ph.s.Hu..GaD.s.s.s.tD.shhhPlDhh+chtpcGhI.ttlh.hah..shh.Gs..G.s.s.....t.p.t.p.ph.u.tlst.LhtttVDuVlhsu..............	0	38	58	65
+7184	PF07356	DUF1481		Protein of unknown function (DUF1481)	Moxon SJ	anon	Pfam-B_20042 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 230 residues in length. Members of this family are often referred to as YjaH and are found in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.	25.00	25.00	25.80	25.30	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.25	0.71	-4.85	17	658	2009-01-15 18:05:59	2003-09-17 11:01:20	7	3	648	0	52	244	1	185.70	59	83.59	CHANGED	uuGhstscusshhWhp-ctsps..thhusasshtssuphpocYRWppspL+plpRps.......stsP.pl+lRFspcG-ssa.QhclsGch..LosDQlshYphcAcpllptocsLcpsplhLhQG+Wp..spolpTCpG.phhp.-h-pph.sal.pR...uohcs.lAaLtuscs........ppLLLlsss-a.ChhpPp	...................ASGFAtDpGAVRIWRKDosDpV..HLLuVFSPW+SG.sTTTpEYRWQGDsLoLIplNlY......SKPPhsIRARFDc+G-LSFMQREssGcKQQLSNDQIsLYRYRA-QIRQhSDALRpGRVlLRQGRWH.h-pTVTTCEG.pTlKPDLDSpAIuHIERRQs+SSV-VSVAWLEAPEG........SQLLLVANSDF.C+WQPp......	0	3	12	32
+7185	PF07357	DRAT		Dinitrogenase reductase ADP-ribosyltransferase (DRAT)	Moxon SJ	anon	Pfam-B_20108 (release 10.0)	Family	This family consists of several bacterial dinitrogenase reductase ADP-ribosyltransferase (DRAT) proteins. Members of this family seem to be specific to Rhodospirillum, Rhodobacter and Azospirillum species. Dinitrogenase reductase ADP-ribosyl transferase (DRAT) carries out the transfer of the ADP-ribose from NAD to the Arg-101 residue of one subunit of the dinitrogenase reductase homodimer, resulting in inactivation of that enzyme. Dinitrogenase reductase-activating glycohydrolase (DRAG) removes the ADP-ribose group attached to dinitrogenase reductase, thus restoring nitrogenase activity. The DRAT-DRAG system negatively regulates nitrogenase activity in response to exogenous NH4+ or energy limitation in the form of a shift to darkness or to anaerobic conditions [1].	25.00	25.00	69.20	41.30	21.50	16.00	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.73	0.70	-5.20	13	92	2009-01-15 18:05:59	2003-09-17 11:15:03	6	3	79	0	43	88	13	252.50	44	92.94	CHANGED	GHSTNLVGlPs-hLuSssFN-cP.hPLHIuGVREMNssLFEMLupApsLt-AG-AFhsYMsAhFGlDsEQptsc.....sssG+..RRFRuSaLRLL+GWGaDSNGsEGAVLKGWVESRFGLFPTFHKpsIs+huosuWtsYVEEKMuSRFHNNuIalQLDLLYEFCQWALsR....assPGc.oHlsLYRGVNsFcEHplltRlD+RpsVlRLNNLsSFSSDR-lAsCFGDpILTs+VPlsKVlFFNsLLPuaPLKGEGEYLVIGG-YRVssSh.l	.......thNhsslPshlluShtFNcpP...hsLcIsGVRchpssLFchLsttss.t-tupsFpcYMsshFsLt..p.pt.........stsuc...+Rh+..uSYLRLL+GWsaDSNusEGAVLKGWVESRFGLhPoFH+t.lsphsopAahpYhp-+hsupa+sNuI.sQLDLLYEaCQatltR.....th..Pup..pHlpLYRGsNchsEHpllt.....ch.scR.ptllRLNNLsSFoo-R-hAspFGDhlLcspVPlsKllFFssLLPs.hL+GEuEaLVIGGcYcVcht.h....	0	16	31	35
+7186	PF07358	DUF1482		Protein of unknown function (DUF1482)	Moxon SJ	anon	Pfam-B_20128 (release 10.0)	Family	This family consists of several Enterobacterial proteins of around 60 residues in length. The function of this family is unknown.	25.00	25.00	28.10	27.70	23.50	16.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.75	0.72	-4.38	12	929	2009-09-11 12:49:17	2003-09-17 11:20:43	6	1	454	0	29	221	0	57.20	57	86.88	CHANGED	hFALVLhVshlsGsspDlllulYsopppChsAtsEQ+lp.GsCaPl-chIc..s..hPAu	..hFALVLhVhhlsGtspDIlVs.VYsTcQpClhuhs-Q+Ip..GsCaPl-chIc...s...hPAt....	0	2	5	16
+7187	PF07359	LEAP-2		Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)	Moxon SJ	anon	Pfam-B_20235 (release 10.0)	Family	This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cysteine-rich, and cationic protein. LEAP-2 contains a core structure with two disulfide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP-2 is synthesised as a 77-residue precursor, which is predominantly expressed in the liver and highly conserved among mammals. The largest native LEAP-2 form of 40 amino acid residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial model organisms [1]. The exact function of this family is unclear.	21.20	21.20	24.50	23.20	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.85	0.72	-4.32	2	67	2009-01-15 18:05:59	2003-09-17 11:26:34	6	2	48	1	28	57	0	75.00	52	66.92	CHANGED	MhpLKLFAVLhhCLLLLuQVsuSPlPp.SSAKRp.RRMTPFWRuVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE	........................lhAhLh.lhLLLls.Ql.suS..P.l........P.......-...........l..........SS.........u.........+...RR.+...RMTPFWRuVSLRPlGASCRDsSEClT+LCR+t+CShs............................................	0	1	2	8
+7189	PF07361	Cytochrom_B562	Cytochrome_b562;	Cytochrome b562	Vella Briffa B	anon	Pfam-B_18074 (release 10.0)	Family	This family contains the bacterial cytochrome b562. This forms a four-helix bundle that non-covalently binds a single heme prosthetic group. [1].	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.37	0.72	-3.61	25	795	2009-01-15 18:05:59	2003-09-17 11:35:06	6	2	709	109	71	320	3	102.50	48	80.57	CHANGED	s-LcssMpphstshppstcAssspphcpulschcsts.cupptp.Pschcs....p.thpsYpcGhcpLlsplDpApthsppGcLc-AKpuhpclpslRpcYHcKa+	..........tDL--sM-sLscNh....Kll...p...K.A.DsAsplKsA...Lo+MRuA..AlDAQKus.PPKLEsK....usDSPE....M.KDFRHGFDlLlGQIDcALK.LAsEGclc.EAp...AAAcpLKsTRNsYHcKYR..............	0	6	22	46
+7190	PF07362	CcdA		Post-segregation antitoxin CcdA	Moxon SJ	anon	Pfam-B_20349 (release 10.0)	Family	This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein [1].	21.40	21.40	21.40	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.24	0.72	-4.11	25	640	2012-10-02 18:44:02	2003-09-17 11:44:48	7	4	509	9	114	324	32	67.90	35	86.53	CHANGED	sKKssNlolsu-LlppA+shsINlStslEpuLpcpl+c.......pcscpWpcENccAIcshNchl-ppGhFuD-aRpF	...................ppploVTl-s-LhppA+s....h....s..l.NlSuhlssulppEl+c........pt.s..c..R..W.p..t..E.Np..cu.httlsphh-tpG.auD-.Rsa.......................................	0	27	64	88
+7191	PF07363	DUF1484		Protein of unknown function (DUF1484)	Moxon SJ	anon	Pfam-B_20389 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 110 residues in length. Members of this family appear to be found exclusively in Ralstonia solanacearum. The function of this family is unknown.	21.20	21.20	23.10	22.40	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.32	0.72	-3.71	9	55	2009-01-15 18:05:59	2003-09-17 11:47:25	6	1	19	0	24	52	0	101.50	40	86.61	CHANGED	cpppuPQhLAhupp+pLlAQLApphuphs+RstsphAusltpLcssuppIccsTE-uCucLLsVSAGLtGILpLLDLpSDRus-scuLHCLLsPLKpQLDsALsclQcML	.................................t..p.sPphLAhsppppLhupLstpss..s++stt.httslpQLcssut.Ipposc-uCApLLsVSuGLsGILpLL-lpS-+uh.-.C+sLHCLLsPLKtpLDpALs-lQcML......	0	4	13	16
+7192	PF07364	DUF1485		Protein of unknown function (DUF1485)	Moxon SJ	anon	Pfam-B_20495 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 300 residues in length. Members of this family all appear to be in the Phylum Proteobacteria. The function of this family is unknown.	22.00	22.00	23.00	23.00	21.80	20.00	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.80	0.70	-5.22	60	567	2009-01-15 18:05:59	2003-09-17 11:50:56	7	6	358	1	215	587	505	283.50	31	58.09	CHANGED	MRlhlAultpETNTFuPs.oshssFp........thhpGsshhpshps.ssssluualchAct...............pGh.-ll....sslhAtApPuGhVscsAaEplps-ILssl+uu....hshDulhLsLHGAMVu-shDDsEG-LLpRlRsllGsclPlussLDLHuNlTppMlppADsllua+pYPHlDhhEsGpcsscllhchl..pGch+PshuhtchPhlhsh...hsTsppPh+shhcthtphEsc......llulSlhhGFshADhs-sGssllshu-.....DtstAcpsAcclupplashRscahs..phhsh-pulscAhs	........................................M+IhlAuhtpETNTFuPs..sshssFt.........httGsch...ht..t....ph....hssshsuhhchs.t.t..................................p.G.h..pll....sslhAtAtPuG....hVscpAaEplpscllstl...css....h..lDulhLsLHGAMls-sh-..Ds..EG-..LLpRlRtllGs....slPlusshDhHuNlotchlppsDllsua+paPHsDh.hEouc+....us.clL.hchL.......c.......u.......c......h.......+..........P.s.huhhclPhlhsh.t..hsTs.t-Ph.+uhhs....tlttlEtc..G...llusSl....hhGFs..h..AD..hPcsGssllls..ss..........Dt.stupthAccLupthhstRppath...shhshcpulspAh.t............................................	0	35	109	165
+7193	PF07365	Toxin_8		Alpha conotoxin precursor	Moxon SJ	anon	Pfam-B_20562 (release 10.0)	Family	This family consists of several alpha conotoxin precursor proteins from a number of Conus species. The alpha-conotoxins are small peptide neurotoxins from the venom of fish-hunting cone snails which block nicotinic acetylcholine receptors (nAChRs) [1]. 	21.60	21.60	21.60	22.80	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.86	0.72	-4.00	22	253	2009-01-15 18:05:59	2003-09-17 12:37:11	7	1	43	19	0	244	0	41.20	39	81.76	CHANGED	TTVVSFTSD.RASDGRNAAAppKsScLluhs.h+.tCCup......PsCtsppsthC.G	......................s....stpsAApp+sscLhshs..h..p..sC..Cup......PsCtssps.hC............	0	0	0	0
+7194	PF07366	SnoaL	DUF1486; 	SnoaL-like polyketide cyclase	Moxon SJ, Bateman A	anon	Pfam-B_20348 (release 10.0), Pfam-B_4335 (release 18.0)	Domain	This family includes SnoaL [1] a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486.  The proteins in this family adopt a distorted alpha-beta barrel fold [1].  Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation [1].	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.19	0.71	-4.55	29	1134	2012-10-03 02:27:23	2003-09-17 12:44:11	7	18	662	23	389	2430	1653	122.50	20	66.56	CHANGED	thhhphatshh....sptch....cthschlsschhtps........sshhGhcuhtthhpthhp.uhPDlph...plcphls-u.D+VssRhphpGoap.GthhG.....hss..oG+plphpthslh+lpc.GKIsEpWshhDhhulhpQL	...........................................................................t...hphh.thh....s...pt.ph.....s.h.h.s.p....h.h.s....s....c..h..h.......p...............................sth.G...h.....p..u...h.t....p.h.h........p.....t....h..h..p.....s.......h......P.....D....hph............pl..c..........p...h...l......s.........p.....u.....-........p..........V.....s......s.....+..h....p.....h.pG..oa.....p....G.....h....h....s....................h.s.s..oG+.plph...p...t.hsh..h+..h..c.s....G..+Is..-pWt.hhDthshhtQl.......................................	0	95	233	320
+7195	PF07367	FB_lectin		Fungal fruit body lectin	Moxon SJ	anon	Pfam-B_20370 (release 10.0)	Family	This family consists of several fungal fruit body lectin proteins. Fruit body lectins are thought to have insecticidal activity [1,2] and may also function in capturing nematodes [3]. 	25.00	25.00	36.50	42.20	19.40	23.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.86	0.71	-4.57	14	44	2009-01-15 18:05:59	2003-09-17 12:52:52	6	4	31	32	22	53	0	129.80	40	82.04	CHANGED	MSYTI.....plRlhpss..sshhplVE+TsWhYANGGTWo-sc..Gth.lLoMGGSGTSGhLRFp.ssuG-hFhVslGVHNYKhWCDllssLps.-sTulplpPcYY........susRhpsp.tQhushpspstcG+slplpaphs-GNsLpAsls	.................MsYsIplclhpsp..sshhplVEpssWpaupGGTWo-ts..Gth.sLoMGGSGTSGhLRFp.sssGEtFhVslGVHNYKpWCDIlssLss.stTultlhPcYY........s..sstRhp.hp.pQhsphphp..s...pGcslthpYpht-GssL.ssl.h.............................	0	7	13	20
+7196	PF07368	DUF1487		Protein of unknown function (DUF1487)	Moxon SJ	anon	Pfam-B_20425 (release 10.0)	Family	This family consists of several uncharacterised proteins from Drosophila melanogaster. The function of this family is unknown.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.26	0.70	-5.11	7	111	2012-10-02 17:28:28	2003-09-17 12:55:20	6	3	19	0	51	291	82	213.40	36	71.11	CHANGED	sWpuPphMllhc-GDlssAhahLlculppPFAsssVAolhVpEoIt-EhlcRl+sph+PLspclupHPsYlpslpclcp..hpschIhu...........psh.ssASPllVh.DhsHpahGs.tPTGllThHTFRshpEssplht+E.sLsFsuVslWsE+lussY-Llstls.sshahlNChsssLp.Ihp.atsppspVllt+saHYEoLhlsGchKhIVaPlushh	...........W.uPpLMllF-sGDlso.Ah.c.h..Ll..p.S..L...p...s..P.F...u..ss..uVA..o..VLlpESIt-pFlpplts...ch........+......P.......L........s......p........p...........V...u....p....H.....P...s.....Y...l....+....o..L......p.....p..lcp.......Lps.csltu....................c.s.h..sp..u...S.....PllVh..D.h...s...H......p...a..L.G....s....GP...T..G.....VlTl.HTFRTspEAsplt.p+E..sLsas.u.VS.lWsE+lussY-LlstLs.sshahlNChsssLsPIhp.atsppspVhltcsYHYEoLhlssch+lIVFPlus.......................................................................................................................................	0	9	10	32
+7197	PF07369	DUF1488		Protein of unknown function (DUF1488)	Moxon SJ	anon	Pfam-B_20604 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.	21.20	21.20	21.50	21.20	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.62	0.72	-4.14	70	961	2009-01-15 18:05:59	2003-09-17 13:14:29	6	1	762	1	202	509	12	78.20	37	90.60	CHANGED	sIpFssp...saDssppslpFsuhssGtplpCtlospsLpch.st...tssp.....ppphlssFcptRtcIEchAcphlpp....sststlhLp	.................tItFPsp..tpastsppslhFsAhlsGhplsCAIos-uLt.+F.......suss.....scp..hLuuFcpaRaDlEEtAEsLIpc.p..scpGhlhL.........................	0	18	60	126
+7198	PF07370	DUF1489		Protein of unknown function (DUF1489)	Moxon SJ	anon	Pfam-B_20654 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be founds exclusively in the Class Alphaproteobacteria. The function of this family is unknown.	25.00	25.00	32.20	31.80	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.79	0.71	-4.65	54	250	2009-01-15 18:05:59	2003-09-17 13:18:14	6	1	248	0	84	197	185	137.40	50	96.12	CHANGED	LlKLsVGs-Sl--LpsW.sp+....ttts.ss.shHlTRMhPKRtsElLs.GGSlYWVIKGhltsRQpllsl-phsssDGIpRCslVL-PcllcspspP+RPFQGWRYLpspDAPsDLs.tucsst.ssLPscLpppLs-LGll	..........LlKLsVGs-Sl-DLtsWhspR........pst...uh..s..spth.HsTRMhPKRt-ElLs.GGSLYWVIKGplpsRQ+llcIcshscu-GIsRCpLVL-Pcll.spspP+RsFQGWRYLpsp-APtDLs....sucuut...ssLPscL+pELscLGLL...	0	23	54	64
+7199	PF07371	DUF1490		Protein of unknown function (DUF1490)	Moxon SJ	anon	Pfam-B_20678 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. Members of the family seem to be found exclusively in Mycobacterium species. The function of this family is unknown.	21.00	21.00	21.30	21.70	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.85	0.72	-4.03	8	169	2009-01-15 18:05:59	2003-09-17 13:37:13	7	1	75	\N	23	55	1	90.00	60	95.79	CHANGED	MVhaGLLAKAusoVVTGlVGVuAYEsLRKAluKAPLRpsAVoustLGLRGoRKAE....EAAESARLKlADVMAEARERIGEEsPsPAluDs.c-	........................MshashLAKAssTVlTGLVGVsAYEsLRKAluKAPLRpuuVossAhGLRGTR+AE....EAAESARLpVADVlAEAR..ERIGEEuPsPAlucsc...........	0	8	13	19
+7200	PF07372	DUF1491		Protein of unknown function (DUF1491)	Moxon SJ	anon	Pfam-B_20742 (release 10.0)	Family	This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in the Class Alphaproteobacteria. The function of this family is unknown.	25.00	25.00	42.00	42.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.27	0.72	-4.11	53	260	2009-01-15 18:05:59	2003-09-17 13:39:21	7	2	258	1	89	215	166	106.20	37	92.50	CHANGED	LsuchWVsAhlRRlpstGhsAhVhp+GDcsAGAVlVK.lssh-GpApLappuhph........sGsRtWhhh....ssssEs-lDstlsRppcFDPDLWllElED.+pGc+hL-ps	......LpochWVuAhlRRlpssGs..Ahlt++Gss-AGAlhlK.lss..h.sGpssLau.usps............sG-Rhahph......pssc-tsscstlpRch+FDPDLWlVElED.cpupchh..t.......	0	25	58	68
+7201	PF07373	CAMP_factor		CAMP factor (Cfa)	Moxon SJ	anon	Pfam-B_20762 (release 10.0)	Family	This family consists of several bacterial CAMP factor (Cfa) proteins which seem to be specific to Streptococcus species. The CAMP reaction is a synergistic lysis of erythrocytes by the interaction of an extracellular protein (CAMP factor) produced by some streptococcal species with the Staphylococcus aureus sphingomyelinase C (beta-toxin) [1]. 	23.30	23.30	24.20	24.10	23.00	21.30	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.55	0.70	-4.85	9	517	2009-09-11 06:24:37	2003-09-17 13:44:42	6	3	137	\N	15	141	1	226.20	41	81.27	CHANGED	spsos.ts...pp..tstptcphhptLNtchspLpsh.pcslpGo-.....htcplschlcssccLKsulcs.sc...shYDhsSIssRVEhlsssl-sIphuTpsLpsKVppAHl-hGhuITKhlIhllsPhuoscplcsplsslKth.tKV.sYPDLpPTDtATlYsKsKLsKtIWpsRhsRDppVLshKshcVYptLNKAIT+AsGVphNPpsTVtpVDptlpsLpsAhQTALc	............................................................................ss...........tpshsss-AcptlptlNuRIspLpcs.QKss.uSp............ht-pIpcLLc.s.....AhcL+ssl-sls+...G..sl...shhDh.soIssRVcLlssssDTIpsAspTLQsKVpsAHs-lGLpIs+AlllhlsPsSTssQLp-EhAAlKstls+lpsYPDLpPsDsATlYsKspLs+tIhQlR.....hsRsppl...lshKstsshctLN+AIo+AsuVphNstsTVupVDpAlppLcAAYQsALp................................	0	13	14	15
+7202	PF07374	DUF1492		Protein of unknown function (DUF1492)	Moxon SJ	anon	Pfam-B_20776 (release 10.0)	Family	This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length.  The function of this family is unknown. It appears to be distantly related to Pfam:PF08281.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.28	0.72	-3.90	6	341	2012-10-04 14:01:12	2003-09-17 13:47:25	6	2	248	0	28	243	4	92.40	22	68.36	CHANGED	LLSSPKWpsDKVQGGp++KhDDVYl-Llsh....KEsIEpcTsEAIp++lELp+hIspLcNscSRolLpMVYIsKhssaplhDcLshS+oTYY+hh+.Ah+ELs	...........................................h.t.............................t....h.hh.h.....p......h.p..ph..tphhp....pp.h...c..lp...p.hIs.c.Lt......s..spp...R..p..lLp.hhYl..s..c..hs..h....p..lsccls.hS.csohYcl+pcAlpcL......................	0	11	19	22
+7204	PF07376	Prosystemin		Prosystemin	Moxon SJ	anon	Pfam-B_20835 (release 10.0)	Family	This family consists of several plant specific prosystemin proteins. Prosystemin is the precursor protein of the 18 amino acid wound signal systemin which activates systemic defence in plant leaves against insect herbivores [1].	25.00	25.00	49.00	283.70	24.40	18.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.91	0.71	-11.58	0.71	-4.92	3	8	2009-01-15 18:05:59	2003-09-17 13:55:29	6	1	7	0	0	9	0	197.50	82	99.87	CHANGED	METPSYDIKNKGDDVQE..KTKL+HEKGGDE+tKIIEpETPSQDIpNKs........DDAQphPKVEHEEGGstKEK.lEKETlSpCIIKhEGDDAQEKlpVEYEEEEh.KEKIVEKETPSQDIuNKGDDAQEKPK.......................................................................VEHEEDGDEKETPSQDI.KIEGEDAQEIPKVECEERE...KIVIRVDLAVHSTPPSKRDPPKMQTDNNKL	.......MtTPSYDI.KNKGDDhQEE.KVKLHHEKGGDEKEKIIEKETPSQDINNKDTISSYVLRDDsQEIPKhEHEEGG.sKEKIVEKETISQhIIKIEGD.DAQEKLKVEYEEEEYEKEKIVEKETPSQDINNKGDDAQEKPKVEHEE.GD-KETPSQDIIKhEGEGALEITKVVCE......KIIVRtDLAVpSpPPSKRDPPKMQTDNNKL	0	0	0	0
+7205	PF07377	DUF1493		Protein of unknown function (DUF1493)	Moxon SJ	anon	Pfam-B_20460 (release 10.0)	Domain	This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in Salmonella and Yersinia species and several have been described as being putative cytoplasmic proteins. The function of this family is unknown.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.53	0.72	-3.97	18	511	2012-10-02 01:16:24	2003-09-17 13:59:56	7	2	255	0	69	887	434	104.30	38	92.53	CHANGED	M..sslppclh-hl+cchGshh.....tchpLT.so-LcpDLplstsDsc-LhpcFhccFsV-husFphppYF.P..pssh..hhs.hc+p......csc.l..PlTluMLhcSA+AG+WLYD	.......................................-slppplhcLlRpph.s..h..Y.lh....KphpLo..-oDLpp.D.Lplst--sp-LMscFFccF.....NV-tusFphpsYF.P.........p...Ph........h..p....F++p.............-...s...shTIuMLl-SA+AG+WLY...............................................................	0	5	17	48
+7206	PF07378	FlbT		Flagellar protein FlbT	Moxon SJ	anon	Pfam-B_20574 (release 10.0)	Family	This family consists of several FlbT proteins. FlbT is a post-transcriptional regulator of flagellin. FlbT is associated with the 5' untranslated region (UTR) of fljK (25 kDa flagellin) mRNA and that this association requires a predicted loop structure in the transcript. Mutations within this loop abolish FlbT association and result in increased mRNA stability. It is therefore thought that FlbT promotes the degradation of flagellin mRNA by associating with the 5' UTR [1].	19.50	19.50	20.80	25.10	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.38	0.71	-4.28	49	266	2009-01-15 18:05:59	2003-09-17 14:07:26	6	2	220	0	105	208	18	123.60	35	80.56	CHANGED	L+lpL+PtERlllNGAVlcNuDR+spl.l.ss.sslLRp+Dllps--AsTPl+clYaslQhhhhs.sss.pphps.hhptlppLh.hhssscststltpssctlhsuchYcALKtlRsLlshEpcllu	.......L+lsL+ssERlhINGAVlc.u.D.R.+ssLplhNc.AshLhEpclLpPE-AsTPlRplYFssQhMLlt.ssttcp.stshahphlptlhthhpss-hhstLctlsphVtsGchacALKslRsLhshEtclh.s.................	0	27	57	72
+7207	PF07379	DUF1494		Protein of unknown function (DUF1494)	Moxon SJ	anon	Pfam-B_20601 (release 10.0)	Family	This family consists of several bacterial proteins of around 175 residues in length. Members of this family seem to be found exclusively in Chlamydia species. The function of this family is unknown.	23.00	23.00	24.30	24.30	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.11	0.71	-4.34	6	41	2009-01-15 18:05:59	2003-09-17 14:09:44	6	1	37	0	8	18	0	165.00	56	93.80	CHANGED	pKRuFLLhElLVShTLlALLhGsLGFWpR+hasSpKccE+lY+TFLpEshAYKpLRTlF.hoTSpIE-hPGhLhShlFDRGVYRDP-LAGtVtGSLaYcppptRL-L.IpS.Rpcu+.ETh.LhcpV.pV-hVshR.....ppt.uchP-RVhhsl+R+sst.s.RsLoY.FAlG+	..pKRuFL.L.ELLIuhsLIuLLLGoLGaWpR+IahSpKcKE+VY+hFLpES+sY+hLRss................F....hSThuh....Esp.t.hlFS..FDRGVYsDP+LAGsVpGoLHYDshsQclpLhlsS.R-cu+.Eph.LhoHVhph-hpshR......pu.sEhP-RlhLTlsR+ssAhPPRTLoY.FAVG+..............................	0	2	3	7
+7208	PF07380	Pneumo_M2		Pneumovirus M2 protein	Moxon SJ	anon	Pfam-B_20478 (release 10.0)	Family	This family consists of several Pneumovirus M2 proteins. The M2-1 protein of respiratory syncytial virus (RSV) is a transcription processivity factor that is essential for virus replication [1].	25.00	25.00	73.20	72.80	22.90	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.11	0.72	-3.99	3	21	2009-01-15 18:05:59	2003-09-17 14:14:51	6	1	7	0	0	21	0	84.50	67	96.47	CHANGED	MTpPKIMILPDKYPCSISSILIoSEscVssaNHKNlLpFNQNphsNHMYS.NphFDEIHWTSQELIDslQpFLQHLGIsEDIYTIYILV	MshPKIMILPDKYPCSIoSILIoScscVshaNpKNsL.FNQNp.sNHhYs.Np.FsEIHWTSQ-LIDssQpFLQHLGIs-DIYTIYILV........	0	0	0	0
+7209	PF07381	DUF1495		Winged helix DNA-binding domain (DUF1495)	Moxon SJ, Bateman A	anon	Pfam-B_20509 (release 10.0)	Domain	This family consists of several hypothetical archaeal proteins of around 110 residues in length. The structure of this domain possesses a winged helix DNA-binding domain suggesting these proteins are bacterial transcription factors.	21.60	21.60	21.60	22.90	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.84	0.72	-4.31	11	58	2012-10-04 14:01:12	2003-09-17 14:17:45	6	2	37	0	41	59	0	86.40	40	74.89	CHANGED	Ih+SLp+SclR+KILhaLhchhPpshYls-loRcV+ossoNVpGuLcGhGpRYsu-pSLlpLGLV.....pptcsGhK..hYplTc....hG+pls-hL	...............llRSLp+SclR++lLhaLhch...aPpssYluEIuRtltuDsoNVhGuLtGhG.sRYsucpSLltLGLV....pphpps.GhK...hY+lT-....hG+pls-h................	0	11	13	30
+7210	PF07382	HC2		Histone H1-like nucleoprotein HC2	Vella Briffa B	anon	Pfam-B_20179 (release 10.0)	Family	This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has been suggested that it also has other roles [1].	40.00	40.00	40.10	40.00	39.90	39.90	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.98	0.71	-12.70	0.71	-4.44	8	284	2009-01-15 18:05:59	2003-09-17 14:20:42	6	26	180	0	92	272	95	148.50	44	66.11	CHANGED	MlssQK..K+SuKKTAuK..AVRKP.......AKKAAAKKss....sRKsAAKKssARKTssKKsVAtKpsutKtss......+KssAp+hsAtK....................hss+KsVAKKssAKKssAKKssA+KTVAKK.ssA+KsAAKKAs.AKKAsARKsA.A+KAlAK+Asu.............C+KpH+HoAACKRVsoSuAst.tsGuKo+lps.....AHuWRpQLhKhsoR	............................................................tc...s.s...s+.ss..s+K.ss.......AK.K..s.s..s.KKss.......s+K.s.A.sKK..ss...A+Ks.s.s.tKts...A.t..+.p....s..s.sKK.s.....s......AKK...........s.s....s..+K.ss.A.KK.s.s.A.+.K...........ssAKKs.s.A.K.K.s.s.AKK.su..AK.........Ks.s.A+K.s..sAKK.......s.s.A.+Kss.AK....Kss..A.+K.s.s.A.+....K..ss.s.cK..s.s...Ahcss..............................hc.s..s..................................................................................................................	0	19	45	71
+7211	PF07383	DUF1496		Protein of unknown function (DUF1496)	Moxon SJ	anon	Pfam-B_20554 (release 10.0)	Family	This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.	20.20	20.20	20.30	22.10	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.95	0.72	-4.71	21	610	2009-01-15 18:05:59	2003-09-17 14:33:02	7	1	598	0	48	194	3	57.70	63	62.58	CHANGED	pshssuspsspp.......RsCaYpDpsYSpGAVIcl-GllLpCst-schpoNusLhWhplpp	...................EVaSouGQSuQPC.....hQCCVYQDQNYSEGAVIKsE.GlLLQ.CQR......D-KTlSTNPLlWRRVK.P.............	0	3	12	29
+7212	PF07384	DUF1497		Protein of unknown function (DUF1497)	Moxon SJ	anon	Pfam-B_20585 (release 10.0)	Family	This family consists of several phage and bacterial proteins of around 59 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this organism. The function of this family is unknown.	20.00	20.00	22.50	107.80	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.70	0.72	-3.80	2	15	2009-01-15 18:05:59	2003-09-17 14:35:51	6	2	14	0	1	8	0	59.10	92	83.98	CHANGED	MGYYDT+NEARRISKLASQNISSEQsKKEFELDpQSKFNQEMQAEFHE+IKKLGtKNGS	MGYYDTKNEARRISKLASQNISSEQNKKEFELDSQSKFNQEMQAEFHERIKKLGEKNGS...	1	1	1	1
+7213	PF07385	DUF1498		Protein of unknown function (DUF1498)	Moxon SJ	anon	Pfam-B_20610 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 225 residues in length. The function of this family is unknown.	24.40	24.40	24.40	25.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.38	0.70	-5.21	5	356	2012-10-10 13:59:34	2003-09-17 14:43:15	7	1	341	4	50	222	100	221.20	51	98.34	CHANGED	MKRSpIN-IIcEu+AFhpoFsahLPPFAYaSP--WKQR-ssuhpEVhDuRLGWDITDFGpscFAchGLTLFTlRNGuucsh..uhsKsYAEKIMhlRcsQlTPMHaHs+KtEDIINRGGGsLVlELapuDc.sstlD-co-ITVuVDGpppThsAGupLKLcPGQSICLsPGLYHuFWAEuGs..VLlGEVSoVNDDLTDNhFLEPlGRFSsIEEDEPPlHLLCSDYcpa	........................MKRSpINpllccscthhppaphpLPPFAhaoPpcWpp.hst..s.....shpElhDhpLGWDITDFGpscFsphGLoLFTlRNGs..hpsh..sYsKsYAEKlhhl+csQloPMHFH......hp.K.....tEDIINRGG.GsLllcLasus.....ssphs............p...c......oslTVslDGpppThsAGspL+LpPGESIsLsPGlYHsFW.u..E..s..Gh.........VLlGEVSpVNDDppDNhFh.c.P.luRFssIEEDEsshhLLCs-Ysp..............	0	10	26	40
+7214	PF07386	DUF1499		Protein of unknown function (DUF1499)	Moxon SJ	anon	Pfam-B_20643 (release 10.0)	Family	This family consists of several hypothetical bacterial and plant proteins of around 125 residues in length. The function of this family is unknown.	22.60	22.60	22.80	23.50	21.80	22.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.51	0.71	-3.93	120	649	2009-01-15 18:05:59	2003-09-17 14:46:02	6	5	562	0	243	562	331	121.10	25	61.46	CHANGED	tclssssssPsshps.ths............................................pt................tlpslt...............s.sspps........hstlhpll.......pphst.......shl.....ptsps..hlcApspotlhGFsDDlplpls.....ss.ts....hlclRSsSRlGtSDLGsNtcRlcpltstLp	....................................................................................................................h..hsss.tpPsph.s.t.......................................................pt..tltshh...........hp.sssps........hptlpph.h...........pshsh......................shl......h...ppsss......hlcspspStlh..uFs.....DDl..p...l.......plp.........sstt...........hlclRStSR.......h.....G.........h.u.DhGsNtcRlcphhptL..............................	0	79	162	206
+7215	PF07387	Seadorna_VP7		Seadornavirus VP7	Moxon SJ	anon	Pfam-B_20657 (release 10.0)	Family	This family consists of several Seadornavirus specific VP7 proteins of around 305 residues in length. The function of this family is unknown. However, it appears to be distantly related to protein kinases.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.02	0.70	-5.59	5	11	2012-10-02 22:05:25	2003-09-17 14:48:06	6	1	4	0	0	107	14	302.00	56	97.28	CHANGED	hscGQsplh+.tssFcVRFRpcGKlaclPLPNuoT+c......sIlGTIKYFTElMGLslVsNuh+LshsNVuDhp+asGNuTLstlKocl.GsLFLKKlsSLPlslssshY.aNK...YcVFARlHGIl+L+....ND.NNYcYGIILE+CYcIRlhssNhIlAGLKuLMDhHpEssssLHGDCNPpNLMCDKhGhLKLVDPusLlopsVsalN.ppYcuLTs-uEVsuFVhSCLplVucLRslcp--I...FIpchYLsLcosssDsNlpsGsRLTuL.stL-VsS.....DhlStlsMhPFluLLNslcYYslsDllShlpp-lDsEs-V	......................................................................hppGphsIhR...Gs.FclRhRphs+sasMPLPNATosc......NFLDCIKFITEpVGFDYVSsGFKLs.ANVsDFQHLNGNSTLllGKTcI.GPLILKKlRSLPCC..NDsLF.+NK...aRILARM..HGILRLK....NDhNuaKYGVI..LE+C.YKP.pI..N..FSNFl.T.A...I.sD.Lps..FHSu.s.sa.hLHGDsNP-NIMSDusGYLKLVDPV..C.L....L...E.NQVN.MVN.I-YEuLTQ.-AEKKV..F..lKSLLpLVE+QLSAsh-EI........YVsLcEsNPSFN.LpsGh+LTDLLsslDlaNsspWK.h.lNH+PMhPplulLNDLTYYchsDVpshlT-sLsDEDDV............................................................................	1	0	0	0
+7216	PF07388	A-2_8-polyST		Alpha-2,8-polysialyltransferase (POLYST)	Vella Briffa B	anon	Pfam-B_20294 (release 10.0)	Family	This family contains the bacterial enzyme alpha-2,8-polysialyltransferase (EC:2.4.99.-) (approximately 500 residues long). This catalyses the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA) [1].	22.70	22.70	23.10	26.90	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.65	0.70	-6.12	3	54	2009-01-15 18:05:59	2003-09-17 14:48:52	6	1	43	0	2	27	0	403.30	53	97.46	CHANGED	M.....LKKIRKALFpPKKFFQDS.WFsTS.......LFsLpsP+sNLFIISsLGQLNQAcSLIKhQKL+NNLLVILYToKNhKMPKLIpcSsNKcLFSShYLFELPRcPNslSPKKlLYIYRuYKKILpsIQPAHLYhMSFAGHYShLISLAKKpNITTHLIEEGTGTY.....APLLESFoY+PTKhEphaIGNNLplKGYhD.KFDILHVsFPEYAKKIFNAKKYaRFFAHuGGISoSssIANLQ+KYRIS+NDYIFVSQRYPISDELYYKoIVETLNpISLpIcGKIFIKLHPKEMtNKYIMSLFLNMVcINPR.LVVINEPPFLIEPLIYLTsPKGIIGLASSSLVYTPLLSPoTQCLSIGpIIIcLIp+pupQENTshIcEHLEIlKpFDFIKILSDlpssIsss.FKTEEThEhLLKSAEaAYKsKNaaQAIFYWQLASpNslolLGaKuLWYYNAL.pVKQ.YKMcY.-I.YIDpISlsFHDKDKhhWppIKp.aa...KRIhpsc	.......LKKl+KhhhpPhtFFpDS.WhhsS..........Lp..ppNlFlISNLGQLppspShlph.phpsNhLllLhTpKNhcMPKllhpphNKpLFpShhlh.lPppPNsho.KKllahYpsYKhll...pstchYhhSastHYuhhl.lhKKpNIpspLI-EGTGTY............sPllp...Yp...........hIhNsl.l.htY.D.+F-.lassFPphhKKhFNApKasc.FttAsulp.sspIsNl.+KYpIo+sDhIassQ+Y.IpcsLahcSllpIL.pIsh..pu+IFIK.HPKE..pp.l.ul.hshhc..hpsR.lllIsEPsFLIEPlIhhsp.KtlIGLsSSSLlYsPLlS.psQshSIu.LhIpLhpp.p....cshphlp.Hh.-IlKpFs.lpILsD...sIos...................................................................................................................................	0	1	1	1
+7217	PF07389	DUF1500		Protein of unknown function (DUF1500)	Moxon SJ	anon	Pfam-B_20659 (release 10.0)	Family	This family consists of several Orthopoxvirus specific proteins of around 100 residues in length. The function of this family is unknown.	25.00	25.00	35.50	34.80	17.20	15.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.45	0.72	-3.99	2	38	2009-01-15 18:05:59	2003-09-17 14:49:50	7	1	17	0	0	32	0	86.80	73	58.82	CHANGED	MSSSVDVDIYDAVRsFLLRaYYsKRFIVYGhSNAILHNIYRLFTRCAVIPFD.IVRhMPNESpVpQWVhDTLNGIhMNE+DVuVsVGTGlLFMEMFF..h	......................MSSSVDVDIYDAVRsFLLRHYYsKRFIVYGRSNAILHNIYRLFTRCAVIPFDDIVRT.MPNES....RVKQWVhDTLNGIMMNE+DloVsVGTGlhFMEMFF...DY..	0	0	0	0
+7218	PF07390	P30		Mycoplasma P30 protein	Moxon SJ	anon	Pfam-B_20617 (release 10.0)	Family	This family consists of several P30 proteins which seem to be specific to Mycoplasma agalactiae. P30 is a 30-kDa immunodominant antigen and is known to be a transmembrane protein [1].	18.70	18.70	19.20	19.90	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.59	0.70	-4.88	2	12	2009-01-15 18:05:59	2003-09-17 14:56:20	6	2	6	0	1	14	0	189.00	57	98.69	CHANGED	MKLKQLLNLGTALTATFSIPFVAAKCSEDDKKEKVTKPKNEPTKPVDNSKTNDNSNEMVGETNLSNSINSSNSSTQNHFGAETNAKESPALNDLYSENPATPI.p.EKGIKESSEGSKNEGDKVIAGKEAIYKDIDFDISKVKITIDKKDLKDEDLISPKKGSHKQLFFNTYKDKTKVSGKLEKDQKPWGGIAIGSVTGLPKNYSIANADSPLYISKKDKKGTAKPNGFVNVEKDGGNLKIKFRFFKFNKGsNSTVSTKVYEAIIS	.....MKhK.LLsLGTsLTATFSIPFVAAKCuEsDKKEKhpKPhpEPsKPs-NocTsDNosEhs.G.psN.s.sS.N.SsNut.......................Nssss..p.EKtIKEoS-u.Kp-G-KV.stpcshYKDIDFDhSKlKIhIsKKDlKDEDLIssKpGspKQlFFsThp.tTplpGKh..tphPWtGltIGoVTGLPcsYSIuss-sPla...+s+KGphpssGFVNVEK-GspLKIKFRFFKaNKGsssTVSTpVYEAIIS.................................	0	0	1	1
+7219	PF07391	NPR		NPR nonapeptide repeat (2 copies)	Bateman A	anon	Marshall M	Repeat	This nine residue repeat which I have called NPR after NonaPeptide Repeat.  It is found in two malarial proteins and has the consensus EEhhEEhhP where h stands for a hydrophobic amino acid.	25.00	0.00	115.20	0.60	17.30	-999999.99	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.70	0.73	-6.93	0.73	-3.28	73	570	2009-09-16 13:04:07	2003-09-17 15:05:43	6	2	2	0	555	770	0	16.90	67	98.77	CHANGED	EllEEllPEEllEEVlP	........ElVEEVlPEElVEEVlP...	0	555	555	555
+7220	PF07392	P19Arf_N		Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus	Vella Briffa B	anon	Pfam-B_20449 (release 10.0)	Family	This family represents the N-terminus (approximately 50 residues) of  cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis [1].	25.00	25.00	45.60	45.60	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.45	0.72	-3.80	6	33	2009-01-15 18:05:59	2003-09-17 15:41:38	7	1	25	1	7	29	0	50.20	71	51.22	CHANGED	RFlVTVRI..RRAsRPP+VRlFVVphsRuupctoAssspAsVAhVLhLhRppR	..RFLVTlRI..RRACGPPRVRVFVVHIPRhAGEWAAPGA.AAVALVLMLlRSQR	0	1	1	1
+7221	PF07393	Sec10		Exocyst complex component Sec10	Vella Briffa B	anon	Pfam-B_20545 (release 10.0)	Family	This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which specifically affects the synthesis and delivery of secretory and basolateral plasma membrane proteins [1].	21.80	21.80	22.10	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	711	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.36	0.70	-12.95	0.70	-6.35	26	605	2012-10-02 15:56:29	2003-09-17 16:31:31	6	17	278	0	437	610	1	516.80	19	80.29	CHANGED	lppsh-sFspLDpplss................luptssclGcpLcphspp+pp........tlcut.Llpaapchhspup..............................t.LppL.cp.ssspthhcsAplhppLhtlupcl..........................................sssttppspppI-pas-phEpcLLcpFssuY+cp-...hppMpchApl...LppFNGGs....sslphFlsp+phFh.pppph......p.sh......h..l.s..sspt..hh.pshpslhsclpsslppEupIIpcVF....sssppVhphFlp+lappplpphlphlLccspsh...............................SpLuYLRsLpshauhstpLsccLpsa.hts.p...........................................hsshL-pp..hpclF.sal...spYh-pEp+sLcphhtshltcFs.ph....ptp..................htph.st..t.h.........................ssp.t.........spsp.sphsphtpsphp.sppp..........................................................t....phpttcshholshshshl+tstEulsRshpLsp.....sscsscsshslhslLLphlhcpYlcsuL-.ss.........................hthsstc.tppss.ssLh.aLpslphsspIlpLhsthhps.ll.Phlsssssh+pphhptppphhpphEtplsthlpcslcslhsplphlLu.cQKKsDFpPpssshs.......................h..psTpsCtplsshL.spltpthstsls..up........................................................................NLcsFLoElGhclaphLlcHh++apVss.sGGlhlppDlspYpshlcsa....plsplsppFchL+pLusLalV.pP-sLpplsptsth...........................sthshp.lppalppRsDapphthssth	................................................................................................................................................................................................h.........................................................................p.t...............t..Lh.hh.th.t......................................................h......tt...........ptu.hh...p..pL...h.u...pp...................................................................th....h..t.ltth.p.hEpthlppFpt.......t........................ptt..............p....tth.tphuth.....L.thp.tht...............t.s.hth....alp..pp...............................................................................................p.t.hhpth..h.hpp..t..ltthF..............s..........lh.h.hhpp.lht........lt.hhp..hhp....p.t.................................................................................................s.......a..lp.l.......h...t........h...t.h..ppl.............................................................................................t..hpp.......h.pha.....ah....t.Yht.E.t.hpp..t..h.pa............................................................................................................................................................................................................................................................................................................................................................................t.pt.h.s.p.hshphlp.ht...tuhtRsh.h..................................tph..tth.tlh...........hllp.h..tal.t.uh-.....................................t.tt........t..t...t.t...sh...ah.hlp.ss.lhthhp.........hpp.lh...h.h.....sp.ph..............h.......ttp......pth.p.h-.thsthlp...t.............slsshht..hph.hht.tQt..tpD..apP..ttt...........................................................................o.ss.tlsthl.p.t....hp..hhtshs....tp..........................................................................................s.hp.sh.tE.......lu.phhphlh.cHh.pp.th.ss..Guhh.hh..........pD...h...st...Yhphh.p.p.h.......................t.......l...haphLptlsplhll...ts.p.thpphh.p...t................................t.hp.p.hhtahphRtDh........t...........................................................................	0	164	262	375
+7222	PF07394	DUF1501		Protein of unknown function (DUF1501)	Vella Briffa B, Studholme DJ	anon	Pfam-B_20578 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 400 residues long.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	392	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.32	0.70	-5.63	51	1229	2012-10-03 20:55:17	2003-09-17 16:41:31	7	11	455	0	491	1424	2193	366.90	22	81.41	CHANGED	AKplIhLahsGGPSpl-hFD.KPphpphpspsh......................................thttpGpsGh.lu-hhPch..uphsDc....lsll+Shhscths...Hs.AthhhpTGtt................shPohGuWhsauLGsts..psLPsalshst.......tth.tsuspsausGFLsutapuhsh.psssss..............lhslsssss.lstppppptlshlsphspphh......ppsscsphts+ltpaEhAh+....Mpspss-shDlssEsppshchYGhss...t..tt...................FuppCLhARRLlEcGVRFlplhps.......G..........WDpHs.....slppshspts...tplDpshAALlpDLcp+GhL--TLVlasuEFGRTPh.........pss.........tGRDHpspuFohahAGGGl+uGhsaGpTD.....-huhssscss..hplpDlaAThL+hhGlDcpclsathtGc.h+Lss...pucllc-ll	.......................................................................................................................................................................................................................................+tllhlahtGGssthshhs..ps.p..h..hh.ttpsh....................................................u....h.h.s.p...h..hsth..........sphscc..............hslh.u.h.....s..phhs..........cs..u.th.hhts..G.......................h..tsh..h...h..t...h.sstp...............shPshhhht.......................t..sh..ssp..ht....s..G.a...Lsp..hh....ps...h.h..tstsss.............................................hhsl.ss.st...s...h.s...h....t...t...t.tpt..h.s.h..h..t...t....h...st...............tt.ts...s.p.h...t..s.h.ht..t...h.p..h.uhp......................hp......s...t....h.p...s.h..c.l.s.p...-.s..p...t..h..h.p.h.h.G.st.....................................................................hu.t..p..s..l...h...A......p.c......h....h...c..p..G....s..+..h..l.plt..hs..............G..............WDs..Hs.................s.hs......t.....h...sp.hh..................tplDpuluALh....pD...Lp......p...........p......G......h............h.......-.......c......T......lVlhhuEFGRTst........................tN.us....................tG...p.....D......H.spuh....s....h.......h....l....sG...G.......ul....+............G.......G.h.shG..p.s.s........p.h....u...h....t..........t..........................c...lhss.hh.h..hshs.p.t.h.h.h.t.h.up.htl.......st...........................................................................................................................	1	299	398	453
+7223	PF07395	Mig-14		Mig-14	Vella Briffa B	anon	Pfam-B_20642 (release 10.0)	Family	This family contains a number of bacterial mig-14 proteins (approximately 270 residues long). In Salmonella, mig-14 contributes to resistance to antimicrobial peptides, although the mechanism is not fully understood [1].	19.70	19.70	20.20	19.90	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.55	0.70	-5.38	5	242	2012-10-02 22:59:21	2003-09-17 16:48:01	6	3	223	0	34	157	10	250.40	50	88.21	CHANGED	HPLVV-pLu-huuIPVRYLuWEpuGElKAAIssWGRpLALSKDsLKRtGKKuLFDLGNAEIILPsAuDs+ssLRH+sRYLSALNcspIssL+...AQKEQLAhARsPEDFSKKFRYNQRRElRLlEEAGGsVRslu-FSuuElAulYl-LFpRRWG..FPATGA-chAcVlEpLR-LLhGSVLaLNspPIAIQlVYRuEAPpWVSlEYlNGGV..DPETRcFSPGSVLSaLNTQuAWEDARuhsKsLRFSFG..RADREYKDRWCsPsPVaQ..s	..........................................................................................................................................................HPDlV-ahhc+ash+F+F.F.+.acccscIKGA.......YFlsNDppl...uh.hsRRsFPLusDEILlPh...APDl..R..saLPcRTp+LSAL+pspIpNAha...+lspK+QsC...llK.......E...s..FSsKFc+sRRpEhp+FlcpGGoV+sV..u-hS.ucE...LspIa...l-LFc.....pRaGt..p.sshs.A-pLAs.FFSpL+c....LL.....FGalLal-shPCAhDlVLKuESphsVYaDssNGul..cs..EsRsLSPGSlLMWLNlscA+caCpcppKp.LhFShG..+P..-..hEYKchWssPh.sGp.s............................	0	1	6	22
+7224	PF07396	Porin_O_P		Phosphate-selective porin O and P	Vella Briffa B	anon	Pfam-B_20808 (release 10.0)	Family	This family represents a conserved region approximately 400 residues long within the bacterial phosphate-selective porins O and P. These are anion-specific porins, the binding site of which has a higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates, while porin P has a higher affinity for orthophosphate [1]. In P. aeruginosa, porin O was found to be expressed only under phosphate-starvation conditions during the stationary growth phase [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.16	0.70	-5.59	34	1073	2012-10-03 17:14:37	2003-09-17 17:09:15	6	6	497	3	306	1050	285	310.00	14	76.92	CHANGED	hplthp.hpush.phs...tps.tptpsusF..ph+ch+LplpGchsc.......chsYphp.clspssssts..s.ht..............h-hsalsach...scp..hslphG+.ts.aGthEh.sssslthhchu.....-hhs............hh..sshhtGlsssaphssspp.lphplh............ss..pssshsctassp...............thttstsshshshsasushh.sphhphchuhshtppActpssp.hlshGsthshs.......phth.hchhhu..slptphhhsphhp...........ttthpshpapuhhsphsYphsschpha.....................spGhaEsssthcthshttt.............hthp+shsahsGlpaaPh..tpsL+halsYltpchchpptsp..s....ssstlslth.Yph	..............................................................................................h...............ht.......tt...t..t....p....p.s..s.h......ph+c.h+lthp.G..p...hh.p........h.tap..h..p..hc...h......sps..s..s..............................................................lp-Aalpa..ph.........pp.....hplphGphphs..a.....uhp.pht.osp....h.h..h..pps..................h.p..........................................t.h........s..h...t.h..ths...h..t...h..p..h..t..tt...t..h.......h....t..h.shh.............................ss....t..s...s.st.s.....t..h.s..s..p....................................................hth.t.h.....th..............t...............................................................t....ht..........h...t.......t.......t.s.t.....t....t..................h........s........t.t......................hhshph..hhht....ht..h..p.schh..hhthtt..............................h.....s..h....p..h......u.h..asphsahh..h..s....p.....h..........................................h.......h.c...hhh..ths..hphtt................................................ttp.p...th.thGhpaa........th.....ch.hsa.....h....t..p.........................t.....h...h............................................................................................................................................................................................................................................	0	111	228	276
+7225	PF07397	DUF1502		Repeat of unknown function (DUF1502)	Moxon SJ	anon	Pfam-B_20836 (release 10.0)	Repeat	This family consists of a number of repeats of around 34 residues in length. Members of this family seem to be found exclusively in three hypothetical Murid herpesvirus 4 proteins. The function of this family is unknown.	19.00	19.00	19.90	19.40	18.10	17.10	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.02	0.72	-4.32	2	25	2009-01-15 18:05:59	2003-09-18 10:17:58	6	3	3	0	1	25	0	32.90	84	31.78	CHANGED	RSEGAGCPARGAGPPAWGAts.ppsutsRssut.	..RSEGAGCPARGAG.PPAWG..AGPPRRDGGNRGDGAP.......	0	0	1	1
+7226	PF07398	MDMPI_C		MDMPI C-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_20685 (release 10.0)	Domain	This domain is found at the C-terminus of the mycothiol maleylpyruvate isomerase enzyme (MDMPI). The structure of this protein has been solved [1]. This domain appears weakly similar to Pfam:PF08608.	27.80	27.80	27.80	27.80	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-10.04	0.72	-3.41	68	478	2012-10-02 14:08:01	2003-09-18 11:25:45	6	2	187	0	169	384	19	92.60	21	37.19	CHANGED	chsscsls...chlsthssphht...........thsh.hps.tshphpsss..........................................ssVpGssssllhh..hsGRhssss......lpssG-tshhst	..........................................lssDtls.....chLthh.sspht.....................hhhthpsstslpl+so-ss.....................s...st............................sssslpGsutsLlhhhsGRhsssst......lpssGDtslht.t..............	0	61	131	160
+7227	PF07399	DUF1504		Protein of unknown function (DUF1504)	Moxon SJ	anon	Pfam-B_20945 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 440 residues in length. The function of this family is unknown.	25.00	25.00	58.90	58.80	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.56	0.70	-5.82	4	138	2012-10-02 15:12:49	2003-09-18 11:28:01	6	2	121	0	52	121	122	416.10	45	97.30	CHANGED	Mhhss...ulplsuAlLFhsAllHTFhT.ahpRLscop.++..............utLa+lLucVElVFshWAlsLhhhhhhTEGhphuhtYhDSRNas.shFlhAIhllhtoRPIlaFuttVlphlA+.lshsushuaaaTlhhhsPLLusFlpEsuAMhlAAhhLpcphas.osS.+htYAThGlLFsNISIGGhhosFuu.slLhlhsthpW-pSFhLoHFuWKAlLAIhlssshhhhLFRKEh++hPcT.ss.......tssus-+VPshIIslpllh.VGsVlhu+tsslFhG.LFLFaLGFt+hh.hYQD.lhLpcshhVuLFhAGLVlhGs.QpWWl.slhhGMos.uhhhsuhhLohFhDNAhlsYLsp.lsshoDsa+YhlVAGuhouGGLTlluNhPN.sGhhILRspF.suoIH.ltLhLuALsPolIuhhsFhhL	...............................slplhuAlLFslAllHTFhs.aFp+Lu....+c....t.c........+..................................................................uuLaHLLuEVElVFGhWAhsLhhhhhh.....h..pG.hpt...........uhsYh-.S.R.NaTEPLFVhslMllAuSRPILphspphlptlA+.....lsh....psshuhaaslhshsPLhGSFITEPAAMTlAAllLscphaph.ssss+hpYuTLGlLFVNlSIGGsLTuaAAPPVLMVAspapWssuFMhspFGWKAslAlhlssslhhhlhR+c.h..t.p....h..s...ps..hts............t.hpcp.....lP.hhlhhlHl.lhLlG.l.Vl.h.A.HaPsl.FlG.LFLFFLGFspAhttYQs..LhL+cuLhVGFFLAGLVlhGGLQpWWLpslltuhsshslahGAhsLTAhsDNAAlTYLuS.L.lsuho....................Ds....a+YhlVAGAVoGGGLTVIANAPNPAGhuIL+spFscsulushtLhLuALsPTlluhhsFhhh...........	0	18	38	46
+7228	PF07400	IL11		Interleukin 11	Vella Briffa B	anon	Pfam-B_20854 (release 10.0)	Family	This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11 [1]. Family members seem to be restricted to mammals.	25.00	25.00	27.70	27.00	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.28	0.71	-4.78	3	55	2012-10-02 01:28:15	2003-09-18 11:38:20	6	2	31	0	23	43	0	175.50	46	79.67	CHANGED	MNCVCRLVLVVLSLWPDTAVAPGPPPGSPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQsPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL	.................................................................................h-hDphs..T+pLLtsT+pLstph..+D.+.FsuD.u.-...Hs.LDSLPsLu.hS.AusLuu......LQLsusLopL+uDLhSYh+HVpWL+RAuss.SL+oh-PELGslpu+Lc+LL++LQLL.MuRL..sLPQssPssPusPLsPPuSs.WsslpuuHtILttL+LhhDWAsRuLlhLKs+........................	0	1	4	11
+7229	PF07401	Lenti_VIF_2		Bovine Lentivirus VIF protein	Moxon SJ	anon	Pfam-B_21067 (release 10.0)	Family	This family consists of several Lentivirus viral infectivity factor (VIF) proteins. VIF is known to be essential for ability of cell-free virus preparation to infect cells [1]. Members of this family are specific to  Bovine immunodeficiency virus (BIV) and Jembrana disease virus which also infects cattle.	22.00	22.00	22.60	23.20	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.38	0.71	-5.18	2	22	2009-01-15 18:05:59	2003-09-18 11:45:31	7	1	15	0	0	22	0	133.50	40	59.32	CHANGED	MERTlQSshGRRRGSSsRt+tpsslISsPuYAlaPsPpaRYPRWEFVhps.YS.TAplpKtclllTYpYAlWtR.WpIpTGFhD.uhhMTPAGTHTTtElscLDLFWlRYs.C.Hc.P.Wh-hLhGphs.+hSCRRshQAuVlopT..HoLQRLAuLpLssNtsLCWYPlGplscsoPLWhpFooGKEPTIQQLSGHP	...................................t.t.p...hhhh.hhtt.t.hctcch.ah.........................................................................................................aa....ltlCSCpKc+acI..REFhlG+HR.WDLCKSChQGEIV+pTcP+SLQRLALL+lscsHVFQlMPLWRARRs......................sh.h.h.ppsh.........	0	0	0	0
+7230	PF07402	Herpes_U26		Human herpesvirus U26 protein	Moxon SJ	anon	Pfam-B_21150 (release 10.0)	Family	This family consists of several Human herpesvirus U26 proteins of around 300 residues in length. The function of this family is unknown.	25.00	25.00	502.10	501.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.95	0.70	-5.12	2	6	2009-01-15 18:05:59	2003-09-18 11:51:38	6	1	6	0	0	7	0	293.00	61	99.15	CHANGED	Mhplh.SF.hGLshGsVIPG..sF+hh.t+o.htQlsllhhhuhuhLLTa+Rhs.h.YpPhsDhKIlhLSLhs.phss.h.hVlh.hLhFSEhRLRhIlsRChhIhPoaS.AsahGhhlulhhK.p.hscYplLlTsh.lhPhsspYtahlpSptFhhsLQ+Y+PIhKssu.hphslKsllhahlpFLhLhhllWhGKhaLsh.pspHLFFLsVlpsshFhhplaphshCullslLuGlhhphChapllFEhFlGLGaSulhhplSpsltc+shasGDLLNhFaC.sshshaF	MRRLTDSFILGLAKGAVIPGLYsFRMTEGRSsLtQIGVlITVAISFLLTFKRFDPRFYKPIGDFKIVFLSLMAsKLPShLSAVVMICLIFSEMRLRMILSRCVhIMPSYSPAVFTGhMVSLFFKSQMFDDYSVLlTsA.LLPhTlRYGWMIRSSGFLluLQKYRPILKSTSFREVDLKsLVKFTVEFLLLFTlLWIGKhFLSMPKSNHLFFLTVVNNVFFKLNVFKAAACAlVAILSGLMMNVCLYRIIFEAFlGLGFSSIMLsLSSDLKDRSFYAGDLLNGFFCLVVCCMYF	0	0	0	0
+7231	PF07403	DUF1505		Protein of unknown function (DUF1505)	Moxon SJ	anon	Pfam-B_21179 (release 10.0)	Family	This family consists of several uncharacterised Caenorhabditis elegans proteins of around 115 resides in length. Members of this family contain 6 highly conserved cysteine residues. The function of this family is unknown.	25.00	25.00	69.40	67.10	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.08	0.71	-4.14	7	20	2009-01-15 18:05:59	2003-09-18 11:54:03	6	1	4	0	20	20	0	113.80	34	82.02	CHANGED	Ms.hh.oVllhuh....slAhsssssSp..opsaspsppCh....Sscspsh.....pCphosshphppsSsCshSpYhhppsp...tssp..ss.NtVsQCopTPCsus-KlssDCtsAFu.-+lupIp	.......Mp.hh.sVLlluh....hlAhsss..ssSphpospa.sp.ucpCt..p..sssspsh.....pCphsuTWchppsssCslSpYhKKshs......ssss....-PhNGVAQCTKTPCsuoEplssDCssAFu.-+lupI.....	0	7	7	20
+7232	PF07404	TEBP_beta		Telomere-binding protein beta subunit (TEBP beta)	Moxon SJ	anon	Pfam-B_20928 (release 10.0)	Family	This family consists of several telomere-binding protein beta subunits which appear to be specific to the family Oxytrichidae. Telomeres are specialised protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. TEBP beta forms a complex with TEBP alpha and this complex is able to recognise and bind ssDNA to form a sequence-specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes [1]. 	20.70	20.70	20.90	424.90	18.50	20.60	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.33	0.70	-5.33	3	15	2012-10-03 20:18:03	2003-09-18 12:45:53	6	1	5	14	0	19	0	279.10	75	97.26	CHANGED	MSKGQpA.QQQSAFKQLYTELFNNGGDFSKVSsNLKKPLKCYVKESYPHFLVTDGYFFVsPYFTKEAVsEFHuKFPNVNIVDLHDKVIVINNWSLELRRVNSAEVFTSYANLEARLIVHSFKPNLQERLNPTRYPVNLFRDDEFKTTIQHFRHQALQQSIAKNlKQENLPDISKVoGADAAGKKuKVDAGIVKASASKGDEFSDFSFKEGNTATLKIQDIFVQEKGKDALsKluDcsDVt......KVKGGAKGKuKAAoKSA.+GKKsSAKKuDouuSADVRKSVDKIVKYTPNKPSSRKETPQKSQSAPAAGKSSAKKTTTGSKKslPANPSPSGKKSTKTTDQMTMAQFKKYLDWHEKKKGGKTSSGGKVLGKRSAGKASATSG	MSKuQ.s.QQQSAFKQLaTEhFN.GGDFuKVSpsLKKPLKsYVKESYPHFLVTDGYFFVpPaFTKEAVsEFHpKFPNVNIVDLHDKVIVINsWSLELRRVNSAEVFTSYANLEARLlVHSFKPNLQERLNPTRYPVNLaRDDEFKTTIQHFRHQALQQSlAKNlKQENlPDIuKVoGuD...KKuKVDAGIVRASsSKGDEFuDFSFKEGsTAsl+IQDIFVQEKGKDALp+ltsttps.......KV+GGA+GKtKAAoKSA..sKKssAtKt.s.tuADVRKSVDKIVKYTPNKPSSRKETPQKSQSsPA.GKSSAK+ThTGuKpplPANPSPSGKKSTKTTDQMTMAQFK+YL-WHEKKpsGKTSSGGKVLGKRSAGKASATSG.	0	0	0	0
+7233	PF07405	DUF1506		Protein of unknown function (DUF1506)	Moxon SJ	anon	Pfam-B_20962 (release 10.0)	Family	This family consists of several bacterial proteins of around 130 residues in length. Members of this family seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	25.00	25.00	27.50	27.00	23.40	23.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.71	0.71	-4.15	2	112	2009-01-15 18:05:59	2003-09-18 12:48:34	6	1	27	0	8	63	0	123.40	63	98.52	CHANGED	MNGVRKRLSDMSFRMINVFKDPpPL+FYKGTVVKLENDSSYQRVFDKNKYTEFAGVIIDI+PQELAlLYDSDMSDIQGYSKLYTYQDLNYELKDRISIuDLlYFEIFSIDSSIGYFTLVLKEFIWTN	...................................................MsGVRKRLuDMShRMINVFK.D.PpPL+FYKGsVVKLENDuSYQRlFDKNKYTEFtGVIIDI+PQELAhLYDSDhSDIQGYSKLYTYQDLNYELKDRISIuDL..VYFEI...F...SIDSS....IGYFTLVLKEFIWT.........................	0	4	5	5
+7234	PF07406	NICE-3		NICE-3 protein	Moxon SJ	anon	Pfam-B_21003 (release 10.0)	Family	This family consists of several eukaryotic NICE-3 and related proteins. The gene coding for NICE-3 is part of the epidermal differentiation complex (EDC) which comprises a large number of genes that are of crucial importance for the maturation of the human epidermis [1]. The function of NICE-3 is unknown.	20.20	20.20	20.60	22.30	19.10	20.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.05	0.71	-4.79	6	138	2009-01-15 18:05:59	2003-09-18 12:56:57	6	5	89	0	77	153	0	165.80	46	65.51	CHANGED	huSphp.LSGVslVLlhuaGsLlhllLFIFsKRQIMRFsl+SRRGPHVPlGHsAPKsL+cEIEtpLs+lQ+IpaEP+LLu......sDcs+alp...tssps..hhsYhYRMKAlDsl+-h-h.lpchutu.ophsGcslRuaLh.Lpspps.hpGscptLIDplhDhYE+ARHssstFGcsEYh+YpphLpcLsss	.............................................p.LSGVsllllhuhGsLsh.....llLFIFsKRQIMRFsh+.S.RRGPH.VPlGps.AsKs.L+cE.I-hRLsclQc.Ip.aEPpLLs......s.-.c.s+hh.....ps..ppp....t.sYhY..RM.KAlDsl+.s.E.hshpptspp.pphhGcshRuaLhpL+s....p.u.sPhcGs..ppsLIcplhDsYEpARaGss..sFGpsEYhcYpctLpcLss.s.....................................	1	23	28	50
+7235	PF07407	Seadorna_VP6		Seadornavirus VP6 protein	Moxon SJ	anon	Pfam-B_21021 (release 10.0)	Family	This family consists of several VP6 proteins from the Banna virus as well as a related protein VP5 from the Kadipiro virus. Members of this family are typically of around 420 residues in length. The function of this family is unknown.	19.60	19.60	19.60	19.70	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.36	0.70	-5.72	2	17	2009-01-15 18:05:59	2003-09-18 13:01:11	6	1	9	0	2	13	0	319.60	46	81.38	CHANGED	MMIALIQMKNMKCTLKVEETAENHELEGVSFDELsALREENAKLKpENEhLKTKlHRLESDWTTSDIVEKlELMDsQF-RIGKIMDKMREPMLFKRD-IELHGDLLARVEGLLRIKNERSEVEF-KDIQCIVGRYFSDEsKQRNLEKMIKoFEYDDIADTIALRLTaFIQDPGLRSIVYAMCKAAVLNQNYLNIEVQEIVDVTRQKYTHNARDDIDFYPMFTFDANVPEGVFDHIYKKHYLsPQSAALVHTLSHLDVNVDGsGIAhYHIGSATRFAECSVVYVDGRAYKPIRVMAEYAIFPTLPHEYKGRVEGLLLLHGGLAPITLVRVYHDVNVGGLVTGSIAASVSTLlRNCMLYSFDlYFTPNGlCINAVGNNNhVNIIDIsCCGRAFGKAPLDQGsWNRNKFMGHKHG+GSKCKQY	.....................................................................phsALRpENu+LKpENEtL+sKlcRL..Eu-hppScllEKhpL.h.-s..pa-+lsKIMDK..h......Rc..shL......Fc+D-lcLcusLLARl-sLhRlK.cpsp........psllttYFs.DtscpcsL.chl+o.pas.hhcsht.Rlhh.IpsssLhshshthCthhhh.s.Nh.NlpspplhclstpKYpHsh.ss...Y.hhs..hplspthhDHIYtKH.ls.pshslhHhhSHLsVNVsGsslAhYHlGsusRhsEsSVl.l....-s..RhaKPl+s.u.YAIF.pLPpEhchRVpGLL.hHhGlsPITLVRsht-lp....shhloGslusSlosLh+shhL.ph-lhFs.pGlhlpssGspshsph...sCCtpAFu.....................................................	3	0	1	2
+7236	PF07408	DUF1507		Protein of unknown function (DUF1507)	Moxon SJ	anon	Pfam-B_21047 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	25.00	25.00	63.00	62.80	18.70	17.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.97	0.72	-4.24	14	527	2009-01-15 18:05:59	2003-09-18 13:03:12	6	1	527	4	46	155	0	89.70	58	95.66	CHANGED	sc.ths.pccAhtLLpuDA-KIh+LI+VQhDsLThPQCPLYEEVLDTQMFGLSRElDFAVRLGLI-cc-GKplLscLE+ELStLH-A.hpc	......p...hsh+ptAlp.LpcDA-+IL+LIKVQhDNLTlPpCPLYEEVLDTQMFGLo+EVDFAV+LGLl-cE-GKplhhcLE+ELSpLHEAFTp.......	0	12	29	38
+7237	PF07409	GP46		Phage protein GP46	Vella Briffa B	anon	Pfam-B_20855 (release 10.0)	Family	This family contains GP46 phage proteins (approximately 120 residues long).	22.50	22.50	22.70	23.70	22.00	22.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.53	0.71	-4.77	25	364	2009-01-15 18:05:59	2003-09-18 13:04:22	7	1	322	0	50	265	9	111.60	37	81.26	CHANGED	ssLpsAVlISLFTDRRA.............tssD...s.sss-pRGWWGDoasss.....plGSRLWLLpRpKLTsc..shpcAcsYAcEALpWhl-DG....hApulsVpup...psphspLsLpVplshs......DGshhshsasstW	..................................sLppAVlISLFT.RcA..............tssD..............ss....s..hG.WWGDoa.s...........plGSRL.WLLp.RpK.hTsp...lhppActYAcEAL...pWll-DG....hsspIsVpsp.....pst....spLsLslslhps......cGs.h.h.h.pat...............................	0	11	23	39
+7238	PF07410	Phage_Gp111		Streptococcus thermophilus bacteriophage Gp111 protein	Moxon SJ	anon	Pfam-B_20904 (release 10.0)	Family	This family consists of several Streptococcus thermophilus bacteriophage Gp111 proteins of around 110 residues in length. The function of this family is unknown.	25.00	25.00	26.40	25.50	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.43	0.72	-3.89	2	14	2009-01-15 18:05:59	2003-09-18 13:07:44	6	1	14	0	1	15	0	98.30	43	76.44	CHANGED	MKpAWpIAKEAstKhGhKAhEahuEuLKMAWo.AK......tchpslcE+hhchG..cYo......hh.sLD.....pFNEl..hthphs.Yt.chhADhDs.thYhhhpKshcst	..MppAWcIAK-AscKFGGKAhEYluEuLKMAWutAKst...ssolschpslcp+h.pKsG..cYo......hh.s.LsauK-hp..............................................................................................................	0	0	0	1
+7239	PF07411	DUF1508		Domain of unknown function (DUF1508)	Moxon SJ	anon	Pfam-B_20853 (release 10.0)	Domain	This family represents a series of bacterial domains of unknown function of around 50 residues in length. Members of this family are often found as tandem repeats and in some cases represent the whole protein. All member proteins are described as being hypothetical.	20.00	20.00	20.00	20.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.23	0.72	-4.53	103	1558	2009-09-14 11:58:01	2003-09-18 13:16:35	7	9	909	14	301	816	131	48.60	40	69.96	CHANGED	spsGcahFpLKAsNGplIu.oSEsYso+suscsGIpSV+pNusssshh-h	...........ussupahFs.LK.A.uNsplIs..oSEh.Yso+sSscpGIsSV+sNusppphh-..............	0	71	186	255
+7240	PF07412	Geminin		Geminin	Vella Briffa B	anon	Pfam-B_20861 (release 10.0)	Family	This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle [1].	21.10	21.10	21.20	21.50	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.43	0.71	-4.63	7	153	2009-01-15 18:05:59	2003-09-18 13:18:27	7	2	84	11	87	154	1	156.00	30	67.08	CHANGED	MssSMKQpp..EpspENlKs........ussPRRTLKhIQPSAsGsLVGRpsE.sKulsKRKhWsspLsSpsspsts.Vt.Eps..ENcs..tslopEAaDLMIKEsPoupYWKEVAEcRRKALYEsLpENEKLHKEIEtKDpEIARLKpENcELtElApHVQYMA-MIERLoGcs.DNLEsLcs.ph......-sEptts-.p..--o-	..................................................................................................................................................................................................+pp..hs.s............t.....t....t.......pp....t...........p......tt...........pptp...........tth..pu....DLh.pp......pPsp......pYWK-lAEcRR+ALh-uLpENc+..LHc...clE...pKppE..Iu...pLK...cENccLtE...l.ApcspahAphl-cL...t...................................................t....................................	0	21	27	52
+7241	PF07413	Herpes_UL37_2	Herpes_UL37; 	Betaherpesvirus immediate-early glycoprotein UL37	Moxon SJ	anon	Pfam-B_21151 (release 10.0)	Family	This family consists of several Betaherpesvirus immediate-early glycoprotein UL37 sequences. The human cytomegalovirus (HCMV) UL37 immediate-early regulatory protein is a type I integral membrane N-glycoprotein which traffics through the ER and the Golgi network [1].	25.00	25.00	34.60	34.50	18.90	17.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.88	0.70	-5.61	6	101	2009-01-15 18:05:59	2003-09-18 13:33:48	6	1	24	0	0	73	0	276.10	58	79.43	CHANGED	sshssslcCpYchshhpc+psps..tChhsChhNtsLlasGsClus+ssl.lNhsh.spuh+c..........t+sshL+lGlpYYhcGhhlRsllucst......psNsoplsGsltC....W.csssoGGplTLNhosp......RhlhsscsthptspWcustpcos.........sVhplLscpsphDhhFLpchCP+Lscc....h.+h+sspsp.pssVpscopsspslhssWspuWusWoKYuEht.h..hhsthshhhpscsRshuch....shlGlFhlsuGohslLsLFCsLShhpRRcll+Dh	..............GhGVSVRCTYHGTDlNlTSNsTSMNCpLNCTpNpTQIYNGPCsGsEu+LPLNVTF.pQSRRp..........WHSVMLpFGFQYHLEGWFPLRlLNESR......-hNVTEVpGElAC...FpNDTNlTsGQLsLNhTG+S..YVLRAlA+TS..PFESpV+W.EE.T.NsTsssos.....pNTsTVMphLspYAESDYIFLQDMCPRFL+R.....olKLoKNppppNsTFT...Gs...N.hToLPhWT.scCcGWpYWTTLShM.....W+NRRSALLRAKSRALGHW....ALLSICTVAAGSIALLSLFCILLIGLRRDLLEDF....	0	0	0	0
+7243	PF07415	Herpes_LMP2		Gammaherpesvirus latent membrane protein (LMP2) protein	Moxon SJ	anon	Pfam-B_21212 (release 10.0)	Family	This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus is a human Gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. The significance of LMP2B and its role in pathogenesis remain unclear [1].	25.00	25.00	88.20	87.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.99	0.70	-5.90	3	276	2009-01-15 18:05:59	2003-09-18 13:47:27	6	1	6	2	0	98	0	230.90	53	99.99	CHANGED	MuSLEMpPLG.AGuPuosGGPDGsEGuuNspYPSuFGSSssoPGP..PssEDh-us-csPPPY-us...sGsctGsYQPLGsQDP.SLYAGLGpsGGsG.LPPPPYSPRc-oSpHlYEEs+.cuoMsPsWLPVIsAPYLFWLAGIAASCFSASVSAlVsoTGLALSLLLLAALsNSYAAQpRKLLTKLTlLVAVVTFFAILLTWlVpPsPpNuIVFALLsAAuGLQuIYlLVMLLhLLhAYRRRWRRLoVCsGLLFLACsLLLIVDAIaQLSPLLGAMTVVALTLLLLAFlLWLSSPaGlGALGAALLTLAAALALLASLILG-LNLATMFLLMLLWTLVIILI...CSoFPtothLLoRWLLYALALLLLASALLAGGSILQT..huusoTEFFPsLFCMLLLIVAGILFILAILTEWGSGSKTYGPVFlCLSGLLTMsAGLVWLTLMpKVLLSAWILTAGCLIFFIGFhLFGVIRFCRhCCFCCLpLESs-RPsTsYcNsV	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+7244	PF07416	Crinivirus_P26		Crinivirus P26 protein	Moxon SJ	anon	Pfam-B_21324 (release 10.0)	Family	This family consists of several Crinivirus P26 proteins which seem to be found exclusively in the Lettuce infectious yellows virus. The function of this family is unknown.	25.00	25.00	518.10	518.00	18.10	17.30	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.67	0.70	-4.84	2	5	2009-01-15 18:05:59	2003-09-18 13:50:21	6	1	2	0	0	5	0	227.00	99	100.00	CHANGED	MNNFPEIFDDESTCDYDKEIDHQELSDTFWCLMDFISSKHGKSVADINSGMNTLINIRKsLNGSGKVVSITDSYNKTYFHSQRGLTNVDSRINIDILKhDFISIIDDLQIIFRGLIYKDKGFLDSADLLDLDKKTTTRKFQEYFNILKIKIIEKIGMTKTFHFNIDFRsTISPLDKQRKCSISSSHKKTNRLNDLNNYITYLNDNIVLTFRWKGVGFGGLSLNDIKI	MNNFPEIFDDESTCDYDKEIDHQELSDTFWCLMDFISSKHGKSVADINSGMNTLINIRKSLNGSGKVVSITDSYNKTYFHSQRGLTNVDSRINIDILKIDFISIIDDLQIIFRGLIYKDKGFLDSADLLDLDKKTTTRKFQEYFNILKIKIIEKIGMTKTFHFNIDFRNTISPLDKQRKCSISSSHKKTNRLNDLNNYITYLNDNIVLTFRWKGVGFGGLSLNDIKI	0	0	0	0
+7245	PF07417	Crl		Transcriptional regulator Crl	Vella Briffa B	anon	Pfam-B_20900 (release 10.0)	Family	This family contains the bacterial transcriptional regulator Crl (approximately 130 residues long). This is a transcriptional regulator of the csgA curlin subunit gene for curli fibres that are found on the surface of certain bacteria [1].	25.00	25.00	27.80	41.40	22.80	19.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.86	0.71	-4.42	17	658	2009-01-15 18:05:59	2003-09-18 13:59:10	7	1	648	2	53	209	5	124.10	67	97.53	CHANGED	slsps.s+uR.LhpphsALGPYlREtQsc-spFFFDCLuVCVsschuPEcREFWGWWh-Lcsp-stFoYpYphGhasppGsWhstsl..pcstcclppThcsFHt+LtphLpp.hpLpLpsss-......schs	........TLPSGHPKSRLIKKFTALGPYIREGpCEDNRFFFDCLAVCVNVKPAPEhREFWGWWMELEAQ.EsRFTYsYQFGLFDKsG-WpuVslp-sEVVERLE+TLREFHEKLR-LLso.hpLcLEPADD....FpDEPVKL..	0	4	13	33
+7246	PF07418	PCEMA1		Acidic phosphoprotein precursor PCEMA1	Moxon SJ	anon	Pfam-B_20971 (release 10.0)	Family	This family consists of several acidic phosphoprotein precursor PCEMA1 sequences which appear to be found exclusively in Plasmodium chabaudi. PCEMA1 is an antigen that is associated with the membrane of the infected erythrocyte throughout the entire intraerythrocytic cycle [1]. The exact function of this family is unclear. 	21.40	12.50	31.70	12.80	18.30	12.40	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.05	0.70	-5.04	8	26	2009-01-15 18:05:59	2003-09-18 14:04:48	6	2	5	0	18	27	0	235.50	36	79.28	CHANGED	MKlISLGLISSIIFSIVLAKNSSsSsSTTGCFsFsRKKsKKlHpsssts....VKup-..-aDPDLPNLKFIDEF-PIsLEssKuRhScLD-sFlSETDGhIIDKVTGF.RRENDSslSGWYlRPYEEDYEcMIplNFIPLp...-YYQ+ppNssHKQusuPsPlsh......hPcKQEhslppp.o........................TlpE-DussLaEDct..................................ElDsEssshh......s-GEs...............cspcEh-pcsls.L........................p-tEcspp...................................hcpplpc.Ycs................hpt-tt..ttpppc.-................c.p..c.--ptsEcs-sccpspc	.......................................tpt.tSt..hspFshhpKKsK.c.hth........hc..c...aDPcLPNlKFI-EFpPlhlEssKtp..cLs-sFlSETDGhIlDKVTGF.RREN-SshpGWYIRPYEEsYEcMIphpFhPLp....p.app.psps.KQ.ssssPlsp.......PcKpcls..pp.l.........................plpEcDt.hlpE-ct.......s.........................plstt..p.h......s-t-t...................ps.sEh-tt.ht.h.........................pt-p.p.p...................................h.ptch.p.Ypt..................ht...pt...tttt...........................................ph...............................................	0	0	3	18
+7247	PF07419	PilM		PilM	Vella Briffa B	anon	Pfam-B_20906 (release 10.0)	Family	This family contains the bacterial protein PilM (approximately 150 residues long). PilM is an inner membrane protein that has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body [1].	25.00	25.00	25.40	32.50	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.45	0.71	-4.67	13	197	2009-01-15 18:05:59	2003-09-18 14:10:46	7	1	167	4	19	125	0	135.90	31	92.57	CHANGED	hVhlllsu......th.tppsspsppptpsupsshlAtphLhatsulNDatYppsspc...GslssspLGLPs..h.-stlpplIstsRlaVWhs-pP..GLsuALpcpSpsSsLlGplpsGpLlsssGsshuloLPuuIs-GslValN	..............................hhhhhlss.......h.ppp.spstpttphsssshh.AsphlhhtsslNDatYspstpc.....Gs.l..ssspL..u..LPs....sscst.lcphlppGRlaVW..h.sppP.....GLsss...L....ppp.ocs.S..uLlGhh..p.sGpLshh.u...G.ss.....s...ulslPA..uIstGulVhhN..........................	0	7	11	13
+7248	PF07420	DUF1509		Protein of unknown function (DUF1509)	Moxon SJ	anon	Pfam-B_21379 (release 10.0)	Family	This family consists of several uncharacterised viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.	20.30	20.30	20.40	22.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.63	0.70	-5.18	3	13	2009-01-15 18:05:59	2003-09-18 14:17:13	6	1	8	0	1	12	1	286.70	43	71.00	CHANGED	MFsGtATIELhERLATSWLTAIRLILoWHPlaA.sRppEP...LE+lCR-GREYIlMLSGTIpssHATWPFWQlMpKCLDWCCSFHsPDD+SCEHGSPRIGIRLEGENphFAPuLGLYSuVMTWTP..IPCasEhPlh.......PRPupSS-s-ssPSTSptps..VARVRPpVlQ++VsKTRPlDsElHRPtPlAhsN......PS.asDEPDhthp.cPQPGPSGQN.........RuPRTPT..L-sVRVtDpPVopsRu.coPSPP.csDpsDsD.slutPsRsh.RTPsspPSSP-oElsEEl.AQPDPWGTpt.hhsNRuuTPDDsSuIo-DSAcGSctshRRPsHSsoGERRloRRNRSE..uRSRSRSRSG-....RRaRRsRlRuhPGRRSsS...Rp.TVLVsSSE---	.........MFsGsuTltLIERLATSWLTAlRhIluWhPhaA..pppEP...L-pLsREuRpYIhhlSGoVpssaATWPFWpVMR+CLDWCCuFHhPcDpSCpaGAPRlGIp.cGpN.hFsP.LsLYSslMsWoP..hsCahp...........sp..psstsps.PSsup.....luRV+Phshpphs.KppP.ch-.Hpshshuh........Po..hc-s-......spsuPStps.........ptspoPT..lpsVhsh-tssshphs.tsPsPP.p.s..s.-.s.u.......hoP.....Ss.s.....h.AQP-sWsh......spptoPsDposh.-Dpschp..th.pP.+Stss-.RhsRcsppc..sRSRSRSRSt-....RRht..chR..PGcppsu...cp.sVls.Ssptp...........................................................	0	1	1	1
+7249	PF07421	Pro-NT_NN		Neurotensin/neuromedin N precursor	Vella Briffa B	anon	Pfam-B_20947 (release 10.0)	Family	This family contains the precursor of bacterial neurotensin/neuromedin N (approximately 170 residues long). This the common precursor of two biologically active related peptides, neurotensin and neuromedin N. It undergoes tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the neurotensin or neuromedin N sequence [1].	25.00	25.00	59.90	59.80	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.15	0.71	-4.76	3	47	2009-01-15 18:05:59	2003-09-18 14:29:15	6	2	33	1	22	43	0	151.40	68	98.12	CHANGED	MtGMNLQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHTSKISKASPPSWKMTLLNVCSLINNLNSsAEEAGEMHDDDLVuKRKLPLVLDGFSLEAMLTIFQLQKICRSRAFQHWEIIQEDILDsGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY	...................tM+lQLVChhLLAFoShSLCSDSEEEMKALEADLLTNMaTSKI..oK...AplP.WKMTLLNVCSLlNNLNo.AEET..GEhcEE.-LlsRRphPtsLDGFSLEAMLTIYQLpKICHS...RA..FQH.WELlQ..EDlLDsGNcK.sEKEEVIKRKhPYILKRQL.apNKsRRPYILKRsSYYY............	0	1	2	5
+7250	PF07422	s48_45		Sexual stage antigen s48/45 domain	Vella Briffa B, Bateman A	anon	Pfam-B_21037 (release 10.0) and Pfam-B_4621 (release 14.0)	Domain	This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation [1]. This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.	20.80	20.80	20.90	21.20	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.37	0.71	-3.99	83	1042	2009-01-15 18:05:59	2003-09-18 14:56:31	8	8	16	1	195	1050	1	122.40	24	32.58	CHANGED	plcG....CDF..........................sssp.....................tpphhspshphs...........psphCplps...pss-l.lGhtCPpp......................................................hplpPssCFcpV....h.........................sppphplpsll.........ssphh.........................tppppphpahtlP.p.hpp........phphtCpCpptp	........................................................................lpG.CDF..............................................ospt...................pphhppshs.s............ttschCslph................tss-l.lGhhCPss.......................................................plpPpsCFpplY............................tsppthclppl.lt.................ts.hh......................................................hsppptphsahplP.pphpc........phpFpCpCpp..t........................	0	44	75	162
+7251	PF07423	DUF1510		Protein of unknown function (DUF1510)	Moxon SJ	anon	Pfam-B_21355 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown.	42.00	42.00	42.50	43.60	40.70	41.50	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.55	0.70	-4.97	16	275	2009-09-11 00:04:00	2003-09-18 15:34:46	6	2	186	0	28	185	0	178.30	36	98.23	CHANGED	SRapp+pK+R+tNhlLNIhIulVllLIllVuspLhh.sssppps.tp..........................c.ptptsscpcpsstEcscsEsK-susss-pcc..............pcccc-spcpcsppp.p......psppstpcsspsssssVccshssssWcPlGTpQoupHsssa.cpuStDWpEMhcAlSYATGlsp-phhlhalGNN..Gs..scAhGslpcKsssp+.YcVpIpWVDscGWKPsKVppL	......................SRhpp+pp+++pNhlLNlhIslV..lhlhllsaplhh.sp.pppts.tp.................................ppsppppstp.pcptK..pcsK-tsp.p-pcp...................tppp..pppp.c.pt.cp.p.pctcc....psptspp.s.tcpstspspcshTpssWKPlGT-....Q..sup.shsa.cpuosDWpEMppAlShAh-lP.pphhhhhlGps..Gp..scAhGslpsKpssc+.YhV.IsWV-scGWKPshVppL......	0	9	19	21
+7252	PF07424	TrbM		TrbM	Vella Briffa B	anon	Pfam-B_21098 (release 10.0)	Family	This family contains the bacterial protein TrbM (approximately 180 residues long). In Comamonas testosteroni T-2, TrbM is derived from the IncP1beta plasmid pTSA, which encodes the widespread genes for p-toluenesulfonate (TSA) degradation [1].	20.90	20.90	20.90	20.90	20.80	20.50	hmmbuild  --amino -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.21	0.71	-4.27	16	280	2009-01-15 18:05:59	2003-09-18 15:52:46	6	1	214	0	27	201	11	115.20	33	74.28	CHANGED	lLTGDTRLACEAlLCLuS..us+PuECuPSLsRYFSIct+KhpDTlptR+sFLNLCPVssp......sPEMtsLpss.lsphsGc.CsssuLNsplcphp.....................thcchthpIssplss.CphhsupsYTDap.....s+Yssssc...cts.Wscuh-hccs.tEh.ppl......pc	..................sCEulLC....L....uu....us...ts...oECpsu.pcaF.s.I.p......t..K.....K......h.s......cThcAR+sFLN.CPssst................s..........................................................................................................................................sh.............................	0	3	16	22
+7253	PF07425	Pardaxin		Pardaxin	Moxon SJ	anon	Pfam-B_21422 (release 10.0)	Family	This family consists of several Pardaxin proteins. Pardaxin, a 33-amino-acid pore-forming polypeptide toxin isolated from the Red Sea Moses sole Pardachirus marmoratus, has a helix-hinge-helix structure. This is a common structural motif found both in antibacterial peptides that can act selectively on bacterial membranes (e.g., cecropin), and in cytotoxic peptides that can lyse both mammalian and bacterial cells (e.g., melittin). Pardaxin possesses a high antibacterial activity with a significantly reduced haemolytic activity towards human red blood cells compared with melittin [1]. Pardaxin has also been found to have a shark repellent action [3].	25.00	25.00	86.60	86.50	19.20	17.00	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.39	0.72	-4.55	3	5	2009-01-15 18:05:59	2003-09-18 16:03:39	6	1	2	2	0	5	0	33.00	95	100.00	CHANGED	GFFALIPKIISSPLFKTLLSAVGSALSSSG-QE	GFFALIPKIISSPLFKTLLSAVGSALSSSG-QE	0	0	0	0
+7254	PF07426	Dynactin_p22		Dynactin subunit p22	Vella Briffa B	anon	Pfam-B_21336 (release 10.0)	Family	This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localises to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis [1]. Family members are approximately 170 residues long.	21.50	21.50	22.00	21.70	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.05	0.71	-4.98	4	123	2009-12-07 10:30:11	2003-09-18 16:29:35	6	4	86	0	67	115	0	154.70	37	86.32	CHANGED	Msc...sLcpLchRLQ.LEpRlYG..tutsucPsKsA-uLs+lQsALuNhAsKRERVKILaKKIEDLlKYLDPQahD+IAlPDuMKLEFILAEEphlsu...........QAALLEQlpshpPlLDSsaIpAVPEpAoKLQRLSQIHIpQQDQsEphosEVK+LhE-YNKMhhLLSKQFsQWDEsL	.......................................................tlp.LptRlptLEphl.......h.G......t..s.ts....t....t...s..p...p...l.sD.uLs.......clpstL...ush..usKRE+l+...h...LaK+..l--L.hK.YLDPp...a.lDcl.slPcu..KLpaILApEp.lhs...........psthLEplppLpPhL-Stt.l.+slPpps.s+LppLuQlalpQp-ps.tlspcsptLhppYNphh..lScpFh.ast...................................	0	22	26	44
+7256	PF07428	Tri3		15-O-acetyltransferase Tri3	Vella Briffa B	anon	Pfam-B_21449 (release 10.0)	Family	This family represents a conserved region approximately 400 residues long within 15-O-acetyltransferase (Tri3), which seems to be restricted to ascomycete fungi. In Fusarium sporotrichioides, this is required for acetylation of the C-15 hydroxyl group of trichothecenes in the biosynthesis of T-2 toxin [1].	20.10	20.10	20.60	23.10	19.70	18.20	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.45	0.70	-5.76	3	46	2009-01-15 18:05:59	2003-09-18 16:55:56	6	2	24	2	6	46	0	385.60	77	81.01	CHANGED	ALPPLVPALYRWESTGu..RcVQRRCVGAEAIVGLEEKNRRSLYDLFIATSLRNIAPASTLLTLRNLKDMFELALVEGRFEHPECACTVSWDDQVAAIISYESPESDESARDWARGCVHVQPTAKSAIDLWTEMEEGRAAAKDNTPSKPIELFLLSDVPTDSTPIPQGATVDILFHSNHLFWDGIGCRKFIGDLFRLVGNHIGLSDStEThKMQWGQEIKNLSPPVVDSLKLDISTLGTEFDDKCTEYTSALVANYKSRGMKFRPGLALPRCuIYKLSADDSIAIIKAVKTRLGPGYTISQLTQAAIILALLDHLKPTDLSDDEFFISPTSVDGRKWLREDIASNYYAMCQTAAVVRVENLKSIAVSHKDEKEIQVRALEKACRDIKKSYDQWLGNPFLEALGLRVHNFEASYLN	........................................................................................ALPPLVPALYRWESTGs....RpVQRRCVGAEAIVGLEEKNRRSLYDLFIATSLRNV.APASToLTLRNLKDMFELALVEGRFEHPEsACTV....SWDD.QVAAIISYESPESDESARDWARGCVHVQPTAKSAIDLWTEhEEGRAA.AKDN.sPSKPIELFLLSDVPTDSTPIPQGATV-ILFHSNHLFWDGIGCRKFIGDLFRLVGNHIGLS..DSA-T.KhQWGQEIKNLSPPVVDSLKLDVSTLGTEFDDKCTEYTSAL...VANYK...SRGMKFpPGLu.LPRC.uIYKLSA-.DSIAIlKAVKTRL.GP.GYTISQLTQAAIILALLDHL.K.PTD..LSDDEFFlSPTSVDGRKWLR..E.DIASNYYAMCQTAAVVRVENLKSIAVS.HcDEKElQV+ALEKA.CRDIKKsYDQWLGNPFLEALGLRVHNFEAuYLp.....................	0	1	2	6
+7257	PF07429	Glyco_transf_56	Fuc4NAc_transf;	4-alpha-L-fucosyltransferase glycosyl transferase group 56	Vella Briffa B	anon	Pfam-B_21451 (release 10.0)	Family	This family contains the bacterial enzyme 4-alpha-L-fucosyltransferase (Fuc4NAc transferase) (EC 2.4.1.-) (approximately 360 residues long). This catalyses the synthesis of Fuc4NAc-ManNAcA-GlcNAc-PP-Und (lipid III) as part of the biosynthetic pathway of enterobacterial common antigen (ECA), a polysaccharide comprised of the trisaccharide repeat unit Fuc4NAc-ManNAcA-GlcNAc [1].	25.00	25.00	28.40	25.20	23.30	24.60	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.18	0.70	-5.50	11	636	2012-10-03 16:42:30	2003-09-18 17:16:37	6	2	599	0	55	333	10	331.10	69	97.20	CHANGED	MTsLIHVLGSDIPHHNpTVLRFFNDpLss.hsspQtR+FMlVup-suL.ssaPALclppFsuKKuLAcAVIApA+usRspRFFhHGQFNssLWLALLoGtI+PsQhhWHIWGADLYEsSpuLKF+LFY.LRRlAQtRVG+VFATRGDLsaatp+HPpVssp..LLYFPTRMcsuLsthssscscsu.phTILVGNSGDpSNcHlsAL+AIHQQF.GssV+lIlPMGYPuNNpuYIppV+psuhtLFsscNLQILoEKLsFD-YLsLLRpCDLGYFlFsRQQGIGTLCLLIQhGlPhVLsRcNPFWQDhsEQplPVLFssDsLstshlREAQRQLtulDKspIAFFsPNYlpGWppALtlAuGEss	...............................................................................MTVLIHVLGSDIPHHN+TVLRFFNDsLAA..TSEHAREFMVsGcDs.Gho-....SCPA....LS.l.pFasu..KKuL...AcAVIA....KAKANRpQRFFFHGQF.NsoLWLAL.LSGGIKPuQFaWHIWGADLY...E....l...S...p.....G......L+.a+LF..Y...P........L...RRlAQtRV....Gs.V...F.A.T.R.GDLSaFA+pH..P.+VRG.E........L.L..Y.....FPTR.M..DP......S.L..NoM.As-.R...QRtG.KhTILVGNSGDRSNcHIAAL+..AVH.Q.QF..G..D.T.V+.VVVPMGYPsN.N-AYI-E.VRQAGLpLFSpENLQlLSEKLEFDAYLsLLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNR-NP.FWQDMsEQ.HLPVL..FTTDDLNEslVREAQRQLASVDKssIA..FFSPNYLQGWppALsIAAGEss................................................................	0	5	20	38
+7258	PF07430	PP1		Phloem filament protein PP1	Vella Briffa B	anon	Pfam-B_20843 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long, four copies of which are found within the plant phloem filament protein PP1. This is one of the constituents of the proteinaceous filaments found in the sieve elements of Cucurbita phloem [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.40	0.71	-4.72	3	26	2012-10-01 19:28:07	2003-09-18 17:18:52	6	3	6	0	14	73	0	125.60	24	88.55	CHANGED	CGQlsssPKWIQIPDVKEhGlQVVIKFIVEQlKIpaGDSLKF-SIYEGWYFELCPNSLKYRLHIKAIDFLGRSLpYEIIIIEEK.hL.RIaKL-SIIVILSPGHhVGPVDPPQVEKWIKIPNLQVPFVQEVSKFAlDEaN.KuGDGLKYlEIYDGWYMEMGQDNIKFRLHLKAKDCLGRlRNYEAlVLVKQFLSKRIKILESF	..............................thh......................................................................................................................sttppWhpI..t..slp..shlQ-LucaAVpEaN..K.......s.s.s..sL+FpcVhpGh.h..clspss.hc.a+.LplhAtct......up.tpYcAhVh.............................................	1	0	8	14
+7259	PF07431	DUF1512		Protein of unknown function (DUF1512)	Moxon SJ	anon	Pfam-B_21354 (release 10.0)	Family	This family consists of several archaeal proteins of around 370 residues in length. The function of this family is unknown.	25.00	25.00	62.80	62.80	24.00	23.20	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.06	0.70	-5.71	5	62	2009-01-15 18:05:59	2003-09-19 10:25:02	7	1	60	0	35	60	28	352.10	40	96.29	CHANGED	ssslaaIlohlLFalLIhLL......pclphhhlhRsIEGpLuhLEchtN-Apppllchhcsccs+-s.....EohlcRhu-FFVIsPVslDPsGIIcRh++LLcpu-D+a+chlcRhsPptDsVpRuslpsAlEllsulshIaKaVRHhLloA+KTsNhhLLlQLQMlLPhlh+lu-oYp-AsNuFlKGVPIGDSAGPLVAupLlucusp...+Ec.p+-TVsuEsElEGR+LhIVKA+GPGSoVGRhGcAVEcllc+h.u...+sccIITIDAALKLEGE+TGuVAEGlGVAMGDsGsEKapIEplAlKYGIsLcAVlIKMShEEAlosMsc-IlsAVccAlERVK-IIpEsscPGDoVlVVGVGNTVGVuQ	........h.....llthllah.lhlhlh........tp+lphh.hhtpslcstLshlcphl....s-ups....chhphLccts.....h..p-s.......cshlcR.hh-aFlI-PVsl-PssIls+h+pllcot--ph+chlp.thsPph..Dshp..hsplpsulEllsuLNhIYKVVRHYhlhA+KhsshhLlhQLQhllPhlhchu-AhpcAhssFhcGhPlGDuhGPLVAtplhhsssp....hps.s+DTVhuEs-a-GR+lhllKAcGPuuTVGRPG-AVcpll-chts....+lshIITlDAALKLEGEcTGslAEGhGVAhGssGsEKhsIEchAs+YsIPlpAlllKMShcEAITtMpKEIhpAspcshchVpclIh-pocPGssVlVlGVGNTsGVuQ...	0	13	19	26
+7260	PF07432	Hc1		Histone H1-like protein Hc1	Moxon SJ	anon	Pfam-B_21362 (release 10.0)	Family	This family consists of several bacterial histone H1-like Hc1 proteins. In Chlamydia, Hc1 is expressed in the late stages of the life cycle, concomitant with the reorganisation of chlamydial reticulate bodies into elementary bodies. This suggests that Hc1 protein plays a role in the condensation of chromatin during intracellular differentiation [1].	20.50	20.50	20.60	20.50	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.91	0.71	-3.94	4	147	2009-12-07 10:22:16	2003-09-19 10:31:06	8	1	117	0	26	101	24	74.90	46	96.62	CHANGED	ALKDTAKKM+DLL-SIQpDLtKAE+GNKAAAQRVRT-SIKLEKlAKlYRKESIKAEKpGLhp+K..PApKA.tAAKs.tpAuKsssKKAsAtssppuKAs.KuKPtoKKTusK.KsKpsShpRuhtK	.........................cchhpKlp-LhtshppD.h........t........p......h......E+GNKAAGTRARKsSL-LEKlhKpFRKtS..lcAuK..................................................................................................	0	14	23	25
+7261	PF07433	DUF1513		Protein of unknown function (DUF1513)	Moxon SJ	anon	Pfam-B_21436 (release 10.0)	Family	This family consists of several bacterial proteins of around 360 residues in length. The function of this family is unknown.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.82	0.70	-5.53	37	313	2012-10-05 17:30:42	2003-09-19 10:33:19	6	4	305	0	85	300	24	293.50	40	81.71	CHANGED	hslPsRuHulsscP............tpscuVshuRRPGpashlhDs.psGp.ht..tltusssRHFaGHGsFSsDGphLYsTENDh.ps.....ucGlIGVaDsp..p..sap+luEasotGIGPHElhhhsDG.....poLlVANGGI.cTcs-tGRtcLNL-oMcPSLsh.lsptsGpLlpphtLs.ph+phSlRHLAlsss..........GpVhhutQapGp.p-tsPLluhactGps.hphhthsppp...htshssYsGSlAsssstthlAloSP+Gsphtla.....ctsoGphltttslsDssGlushssG.................FlsoSGt.....Gp....hhphs.ttht.h...t.......sshtWDNHlhtl	...............h.slPsRuHuluh+P..................shs.pA.VsFARRPGpahhlhDh..psup........lt..hh.su.sssRHFYGHGVaStDGc....hLYATEs........-h.cs........uRGlIGVYDss..p...pap+luEassaGIG.PH-lh..h..hs..DG.......sLVVuNGGl.+Tc.t.GRt.L.....NL-oMpPSLsh....l.stsGplL-phsLstt.+pLSlRHLAhsuD......................GoVhsGpQap...Gpsc..-hs....s.LlAh+ptGts.hp....htst.-p...htthspYluSlAss.....s-..hlssTSPcGsphhlW.....stsoGpllt.ssLsDsuGVsshtsu.................FhloSGp.....Gc..............lhhtss.thp.......ph.................sslhWDNHhst.l..............................	0	17	39	64
+7262	PF07434	CblD		CblD like pilus biogenesis initiator	Moxon SJ	anon	Pfam-B_21452 (release 10.0)	Family	This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis [1]. The family also contains a variety of Enterobacterial minor pilin proteins.	25.00	25.00	41.20	41.10	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.30	0.70	-5.75	5	262	2009-01-15 18:05:59	2003-09-19 10:39:02	6	1	240	3	7	118	1	303.90	54	91.10	CHANGED	IlFIh..phllsStlhuhulpAssssGslscopolu.tDRusuoPl..a.IFssaluGYssSHsL.aDRhoFLCpSSoNsssGACPTscsstspthsGpTNI+LpFTEK+SLA++sLsLcGsK+alacsssCsp.............cMsLNSssspC.spstssGssLsLYIPAGELsKLPoGGlWcATLcLclKRau-sos..aGTYTlNITVDLTDK..GNIQVWLPpF+S.sPRVDLNLRPh.Guu+YSGoNsLDMCLYDGYSTpSsSl-l+FQDD...NpousGcYsLl....KoGus-KcLsYAlSLLhGGKplsPsNGpuFoINssS.L.lNWNRl+uVoLPpISlPVLCWPusLTLso...clssP-AGcYSGpLsITFTPSSpoL	....................................h...t.p.sho............................................................................................................................s.sG.shS..slplhhTEp+SGh+hsltLpGa.+suh..ssst.....h.ss...............h..h....s.ust..Sh........................t...tphlpLal.toEh+pLPIGGlWKu+lKL+.........uss...s................htsYhAsITLNshD...spIslaFPpF.upATPRVpLsLHPh....sNuSp....hu....t.c.s.LDMCLYDGasuNAhShplhlcD-.....ss+..psG.FSlahp.tspos....spscRIDYpVpMh.....sG.t..pIs...VpNspshshss.....lN.hp+l.RPVVLPGIRhAVhCVPsPLTLssptFsVh-KpAGhYhGpLoVhFTPSh..........................	0	0	3	5
+7263	PF07435	YycH		YycH protein	Vella Briffa B, Szurmant H, Mistry J	anon	Pfam-B_21457 (release 10.0)	Family	This family contains the bacterial protein YycH which is approximately 450 residues long. YycH plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG.  YycG forms a two component system together with its cognate response regulator YycF. PhoA fusion studies have shown that YycH is transported across the cytoplasmic protein. It is postulated that YycH functions as an antagonist to YycG [2]. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions [3].	20.60	20.60	20.80	21.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.50	0.70	-5.77	6	596	2012-10-01 23:24:42	2003-09-19 11:16:32	6	2	586	1	74	392	0	421.40	30	97.23	CHANGED	EshKSllLslLVlhSlVLTahlWsFQPDaus.....lsspcsc+s......ppshTtphspslpPhpllh.u+--psphshsssslhcchhssLpphclpslcclpccashs..h...usstI.......pl.FspslPhslF.splhpl-scs..hsphsFsRllIsh-tscsslt.lahlsc-+cpllchssospsh-plhcshcshpuchp.hsplIpsp.....ppchalPscspcLpshchlhsolsspphsphLFsDoohV...R..uSposssoYssuouVhshsscschhcY....pp.hs.-psoShpttclIpsSacFINuHGGaTs-..achash.scosploYphFlsGaPVaNppup.....spIpVTaGscslh-Y+RPhhclD.ss.hccscKpLPouEpVhsuLupps-lch-clssIslGYcMscsossst.....hVpLEPpWahKYcGcW......ahhp-uAtpulE	.................................EthKollLslLVlhSllLTah.lW.....s..hs.Pch.ss..........l.s.s.sc.s.pps.................sps.h..s...tch.ss.s...l.pPhpllh.....+p-p..sp......h.t.........h..s..s...s..s.......l....s....cl.h..ps....L...c.s.t...c...l...c...s.l.p.c....lp...p...cp.shh........hs...sshl............lsFstslPls....s..a.tpl..h.s....hs....scs......ss.p.h.p....FNR.l.l..lDhst.s.cp.....l.Yhl..sc.-.p...c...p.h..hchp.h....o.s...p....s.....cc........lhctlsp...hp...p..c..h..p.....sa...p...chhhNp..................ppclah..P..s.csp..cLp..sh..phlh..ss..lsl.....-.p....h..ps.hLF..s...D.....s..s...h..V...c..ps..c.u.ss.s..s..Y..s....s..s.s.t.....s.h.p.h.s.s.c.sc....h.hcY....ps....s.sptss......sch.tphl.toF-FlNs.HG.Ghhs........p............aR...h..a..sh....t..........t.p....s......u...p......ls....a....ph.F.l....s.....G...aP..lF..N.p.c..uh.........spIpl.....s.h....G.pcs....V.hcYpR.....sLhphs..ss..h..s..s.p..p.p..hoLPsscs...VhssLtp.sss..ls.h..c.c.lpsIsIGYchppss.....pp..p.........sscL.PpWYVcY.c..sp..W...................thp.......................................................................................................................	0	23	47	61
+7264	PF07436	Curto_V3		Curtovirus V3 protein	Moxon SJ	anon	Pfam-B_21777 (release 10.0)	Family	This family consists of several Curtovirus V3 proteins of around 90 residues in length. The function of this family is unknown.	25.00	25.00	82.50	82.40	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.04	0.72	-3.85	3	24	2009-01-15 18:05:59	2003-09-19 11:25:43	6	1	17	0	0	28	0	79.30	84	97.79	CHANGED	MVCLPDWLFLLFIFSILLQAGTNFYGTFQSGSISRKLSsLuSRFDELFlKlQQVVYTRYPSR-RTVDsRRRRGLSAIPEGuEEsoEA	MVCLPDWLFLLFIFSILLQSGTNFYGTFQSGSISRQLSSLuSphDpLFLKlQQVVYoR..sSR-RusDsRRRRGLSuIPEGsEEssE..	0	0	0	0
+7265	PF07437	YfaZ	YfaZ_precursor; 	YfaZ precursor	Vella Briffa B	anon	Pfam-B_21552 (release 10.0)	Family	This family contains the precursor of the bacterial protein YfaZ  (approximately 180 residues long). Many members of this family are hypothetical proteins.	21.40	21.40	21.50	21.40	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.99	0.71	-4.85	3	659	2012-10-03 17:14:37	2003-09-19 11:26:33	6	1	610	0	85	306	5	178.50	63	95.94	CHANGED	MsKatVAulAuLLLVAuSVNAsSFNupsG+-YTNlGlGLGTNTsGLAlSGNWs+SDDDGDVAGlGLGhNLPlGPhpATVGAKGlYhsP--GssGuAVAVGGGLuasIGsSFSLaGEuYYAP-sLSSG.lcSYpEANuGVRYNIhRPlol-VGYRYINhEGKDGsRDNslADGsYIGushsF	...............................................................................MKKhhL.A.G..h.AGMLh...V...SASs.sA.h.SISGQAGc-YTNIGV...G...F.G.TES....TG...LAL.S....G.NWsHN.....D..D.......DG.D............sA.G...V..GL.G...L..N.....l....P....l..G..P....L....hATVG..G..K.GlYTNP....p...t...G..D.E...G.YA.A...AV.GG..GL....QW...c..I..G..s..S....F...RLF..GEYY...YSPDS.LS........SG.Ic..SYEE.....AN...A.GARaT..IMRPlSIEAGYRYLNLu.G.K.D.GNR..D..N.Al.ADGPYVGVNASF.......................	0	13	32	58
+7266	PF07438	DUF1514		Protein of unknown function (DUF1514)	Moxon SJ, Eberhardt R	anon	Pfam-B_21857 (release 10.0)	Family	This family consists of several Staphylococcus aureus and related bacteriophage proteins of around 65 residues in length. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	29.20	29.20	24.70	23.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.16	0.72	-4.06	3	268	2009-01-15 18:05:59	2003-09-19 11:30:45	6	1	176	0	3	46	0	64.60	67	98.32	CHANGED	MWIsISIVLAIhLLIsLSSNSc+t+EI-AL+YhNsYLFcclVKspGhpGLE-YchEl-RI+s-lKc	MWIshoIVhAIlLLlslSlNS-+t+EIpAL+YMNDYLhDclVKspGasGLE-YchElcRhss-lKc.........	0	1	1	3
+7267	PF07439	DUF1515		Protein of unknown function (DUF1515)	Moxon SJ	anon	Pfam-B_21875 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Rhizobium species. The function of this family is unknown.	22.20	22.20	22.20	22.70	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.57	0.72	-4.25	3	22	2009-01-15 18:05:59	2003-09-19 11:41:41	6	4	15	0	12	21	0	107.50	46	88.61	CHANGED	MIDAGVHQQLGTLlAEVKNLREDlR...........RSEDRSDAuRASMaRRMDELVERVsTLEGSsstlpuDITuMKPVT-DV+KWKLMGlGALGVIGIGGAALu..VT..FADVsKRsL.hlLRGG	..........Mh.usltppltsL.t-lcplR-Dh+...........cSED+SssuRssMpRRhDELVERltsL..E.....uuhthlcsDlupMKPVT-DV+..+WKLMGhGALG..VIGlGuAALG..VT..FADlh+Rhh..lh................	0	1	6	7
+7268	PF07440	Caerin_1		Caerin 1 protein	Moxon SJ	anon	Pfam-B_22039 (release 10.0)	Family	This family consists of several caerin 1 proteins from Litoria species. The caerin 1 peptides are among the most powerful of the broad-spectrum antibiotic amphibian peptides [1].	25.00	25.00	28.50	27.50	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-6.88	0.72	-4.02	2	28	2009-01-15 18:05:59	2003-09-19 11:44:48	7	2	9	0	0	22	0	23.90	85	64.33	CHANGED	GLhpVLGSVAKHlLPHVsPVIAE+	.GLhSVLG.SVAKHVLPHVVPVIAE+	0	0	0	0
+7269	PF07441	BofA		SigmaK-factor processing regulatory protein BofA	Vella Briffa B	anon	Pfam-B_21773 (release 10.0)	Family	This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein [1].	22.30	22.30	22.40	22.30	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.40	0.72	-3.99	32	390	2009-01-15 18:05:59	2003-09-19 11:48:48	6	1	376	0	106	283	8	78.00	31	90.69	CHANGED	llu....llllhllstshhpPl...+hlh+lslphllGslhLahlNhhGuhhGl....plsINhlTshluGlLGlPGllhLlllc.hl.l	......................h.lu.llhlhllhtl..h.tsl.......+hlhchlhpsllGsllLallN..lhG.s..hhsh.......aIsINhhTuhlsGlLGlPGVshLlllphh..h........	0	42	82	93
+7270	PF07442	Ponericin		Ponericin	Vella Briffa B	anon	Pfam-B_21790 (release 10.0)	Family	This family contains a number of ponericin peptides (approximately 30 residues long) from the venom of the predatory ant Pachycondyla goeldii. These peptides exhibit antibacterial and insecticidal properties, and may adopt an amphipathic alpha-helical structure in polar environments such as cell membranes [1].	25.00	25.00	27.40	58.60	18.00	16.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.59	0.72	-4.13	3	5	2009-01-15 18:05:59	2003-09-19 13:47:52	6	1	1	0	0	5	0	29.00	71	97.32	CHANGED	GWKDWhKKAGEWLKKKGPGIhKAALKAAT	GWKDWlKKAGEWLKKKGPGIlKAALpAAT	0	0	0	0
+7272	PF07444	Ycf66_N		Ycf66 protein N-terminus	Vella Briffa B	anon	Pfam-B_21840 (release 10.0)	Family	This family represents the N-terminus (approximately 80 residues) of Ycf66, a protein that seems to be restricted to eukaryotes that contain chloroplasts and to cyanobacteria.	20.70	20.70	21.10	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.81	0.72	-4.26	16	155	2009-01-15 18:05:59	2003-09-19 16:08:48	6	2	108	0	55	167	131	82.00	43	29.81	CHANGED	lNhshGPuolLGlhLsluGllLYhlRsh+PEluRDaDlFFuolGLLsGGILlFQGWRLDPILLFuQhLlsGTslFFuhEoIRLR	...............................................................lphshs.uslLGIhLul.uuhsLY...h.l.....Rph+PcluRDtD.lFF.....uulGL..LsGhILhFQ.GWRL..DPIL.FGQhLlsusslaFuhEolRLR............................	2	14	41	53
+7273	PF07445	priB_priC		Primosomal replication protein priB and priC	Vella Briffa B	anon	Pfam-B_22037 (release 10.0)	Family	This family contains the bacterial primosomal replication proteins priB and priC (approximately 180 residues long). In Escherichia coli, these function in the assembly of the primosome [1].	20.50	20.50	20.60	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.21	0.71	-4.79	21	862	2009-01-15 18:05:59	2003-09-19 16:34:29	7	3	792	0	84	387	9	162.00	41	94.83	CHANGED	LppLcsplspLtppsuslscpt.........phpshFDcpLFpsRuphLpsYlpEscpsLstLpptsppsph..tpssaLsE+LsuQIpAlpREluTpslRcp-sts...................pshsclYpcLupHQ-aERRLhsMlp-RchpLspsssh.cpQplp+ElhAhEuRLsRCRpALt+IEcpIsppE+	..................................LppLctpLssLcpcsAslspht.................shpARF.D.....+pLFps+uspLpshL-EAtsNLsuL+psVcpppL............QVAaL...AE+LsAQ....lpAl.sREh...u.....sh.......s.......LRph-sss....................................plsc..h..p....c+RhQH.Q-aE.RRLtpMlt-....R....+tpLu...p....sos......h.sEQQsL..p+.E.lps.hEuRLsRCRcALcKIEppls+hpR......................	1	7	24	57
+7275	PF07447	VP40		Matrix protein VP40	Vella Briffa B	anon	Pfam-B_22295 (release 10.0)	Family	This family contains viral VP40 matrix proteins that seem to be restricted to the Filoviridae. These play an important role in the assembly process of virus particles by interacting with cellular factors, cellular membranes, and the ribonuclearprotein particle complex. It has been shown that the N-terminal region of VP40 folds into a mixture of hexameric and octameric states - these may have distinct roles [1].	25.00	25.00	307.40	307.00	17.30	16.40	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.84	0.70	-5.36	2	35	2009-01-15 18:05:59	2003-09-19 17:02:16	7	1	20	4	0	33	0	287.30	60	91.60	CHANGED	M......susssYNshh..hs..Phtspshsp.h.uD.Lus.tu.sPs.s......sslshssph.usVspAFhLEAhlsl.uhschhhKtlPhWLPLGlhsph.YshspTsAAlhhuSYTlTpFs+.up.hVRVNRLGsGIPsHPLRhLR.GNQAFlQphVlP.s..sp.FTasLTsLhL.sQ.LPsssWpsppsthhsNsh+PulSlHPpL.PIlLPshhtpth+tpc.ssss.l.sI.shl.pL+l..ls.hpslhtIplPt.hhphhpGhh.p.tpspPll.h.hPc.hsL	................h.......susssYNshh..lsssPhus+GANphIsuDQLus.pG.TPs.s......ssLshDsphtGsVspAFhLEAhlsl.uhNchhlKtVPhWLPLGIhuphpYshspTsAALLhuSYTITpFs+sup.hVRVNRLGsGIPsHPLRhLR.GNQAFlQphVlP.s..sp.FTasLTsLhLssQhLPsssWpsSpsplhuNsh+PulSlHPpL.PIlLPshptpth+QHc.ssss.lhAIuslL+pL+l.plstppSlatIplPtshFphhpGhhppptpGSPll.h.sPc.hsL..	0	0	0	0
+7276	PF07448	Spp-24		Secreted phosphoprotein 24 (Spp-24)	Vella Briffa B	anon	Pfam-B_22318 (release 10.0)	Family	This family represents a conserved region approximately 140 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover [1].	25.00	25.00	28.00	27.00	21.00	18.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.84	0.71	-4.22	3	49	2012-10-01 19:28:07	2003-09-19 17:20:33	6	1	38	0	21	46	0	115.00	49	61.56	CHANGED	VLDEDoLVMNLEFoIQETTCRRESGtDPATCAFQRGYaVPTAVCRSTV+MSApQVQsVWARC+WSSSTSESsSSEEMIFGDMLGSH+pRNsYLLGLlsDES+GEQFYDRSlcIMRRsaPPGNRRYsNhp+RARVNoGFE	.............................lspsslsMsL-FuIRETsCp+-SGcDPsTCuFpRGaaVPoAsCRSoVclSupQVQsVa.s+CpWuo.oSESpS.SEE..Mhasshhtspp.R.pp..hshh.p...t.........................................................	0	1	2	5
+7277	PF07449	HyaE		Hydrogenase-1 expression protein HyaE	Vella Briffa B	anon	Pfam-B_21851 (release 10.0)	Family	This family contains bacterial hydrogenase-1 expression proteins approximately 120 residues long. This includes the E. coli protein HyaE, and the homologous proteins HoxO of R. eutropha and HupG of R. leguminosarum. Deletion of the hoxO gene in R. eutropha led to complete loss of the uptake [NiFe] hydrogenase activity, suggesting that it has a critical role in hydrogenase assembly [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.39	0.72	-4.15	9	623	2012-10-03 14:45:55	2003-09-25 11:36:21	6	4	503	19	47	938	96	106.10	58	75.57	CHANGED	LhpRLhsphGhshVD.ssslDcalss....tssuVLhluGDPsRhPEssDsAVlLPELhpsFssthhtullu..ttpE-tLusRFslh+hPoLlhhpcGpalGsLutlpDWsEY	.............................................LWQRhLsR.GWpPVs.tspLDDW.lsp.....sP.D...GV..VLLSS..DP..+..RT..PE.VSDN.P.V...MIuELL...R..E....FP.s.a..o......W...Q.VA.lA...DLEQSEAIGDRFsVhRFPATLVFTs......GpaRGsL.sGIHPWAEL........................	0	12	26	35
+7278	PF07450	HycH		Formate hydrogenlyase maturation protein HycH	Vella Briffa B	anon	Pfam-B_22086 (release 10.0)	Family	This family contains the bacterial formate hydrogenlyase maturation protein HycH, which is approximately 140 residues long. This may be required for the conversion of a precursor form of the large subunit of hydrogenlyase 3 into a mature form [1].	25.00	25.00	28.80	28.80	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.85	0.71	-4.05	19	787	2009-09-12 21:51:00	2003-09-25 12:51:46	6	2	548	0	50	216	2	129.60	66	95.41	CHANGED	scVlFapLs+KFVDpscs...sP-cApQVhYYSLAIGHHlGVlDCLcstLpCPhcpYppWlstLspG.EA+RKhpGlhpFGEIsIspsHsshLApA..........hstlststp.stppph..oppLlchLtsIppEPAIYLMV.R+p	........cVVF.pLs+KFlD.psDs...sPtcAQQVhYYSLAIGH.HlGVIDCLcsALsCPhsEY.sWlAsLEtG.-ARRKMtGV.KaGEIVIDhsHlshLApA..........FDcspsstT...SppQp..W..SphhlshLc-IpQEsAIYLMVRR.l....................	0	6	16	32
+7279	PF07451	SpoVAD		Stage V sporulation protein AD (SpoVAD)	Vella Briffa B	anon	Pfam-B_22130 (release 10.0)	Domain	This family contains the bacterial stage V sporulation protein AD (SpoVAD), which is approximately 340 residues long. This is one of six proteins encoded by the spoVA operon, which is transcribed exclusively in the forespore at about the time of dipicolinic acid (DPA) synthesis in the mother cell. The functions of the proteins encoded by the spoVA operon are unknown, but it has been suggested they are involved in DPA transport during sporulation [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.06	0.70	-5.99	41	555	2012-10-02 12:25:54	2003-09-25 13:15:53	6	4	414	6	107	452	34	322.00	51	97.04	CHANGED	G+QThhFps.PhIlusuolVGP+EGcGPLuchFDhlhpD.hhGc-SaEKAEpphhc-AsptAlpKuslppc..-lcallAGDLLNQlhuooFAARslsIPalGLYGACST.sEuLuLuuhll-uGaAchllsuTSSHauoAE+QFRaPhEYGsQ+PsTAQWTVTGAGAsllu....ppGs................s.PplTtsTlGKVlDhGlpDs.NMGuAMAPAAsDTIhpHFcDhspsPscYDLIlTGDLGplG+pIst-LL.cccGhclspp.apDCGlhIacp-.QsstuGGSGCGCSAlVhsGalhcphpcGchKRlLlVuTGALLSssShpQsESIPuIAHAVsIE	........................G+QThhF.ps.pPhIhuouolsGPcEucGPLuc.FDhla.cD.hhhGpco...aEpAEppLhp-AhppAlpKuslcps..-...Icahl....AG....DLlN......Qh.s......s...o......s...Fu......A.R...p.....l.......s...l...P..a....lGla...G..ACSTuhEuLAluuhhlsuGhAchllsusSSHpuoAE+QFRaPsEYGuQ+PsTApWTVTGAGAsllu......pp.s..s...................................................u..s+lTuATlG+VlDhGlsDPhNMGuAMAPAAsDTIppHhcDhphssspYDLIlTGDLGpVGppIsh-LLp.ccGhc....l.spt..apDCGlhIYc..ps.Q.s.VhAGGSGCuCSAsVshGalLpchpcGchp+lLlVATGALLSPhohQQtEoIPsIAHAVslE..................................................................................	0	54	86	92
+7280	PF07452	CHRD		CHRD domain	Hyvonen M	anon	Hyvonen M	Domain	CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins.  This family includes bacterial homologues. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin (Swiss:Q9H2X0) and Drosophila SOG (Swiss:Q24025). [1].	24.10	24.10	24.10	24.20	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.62	0.71	-3.49	101	936	2009-01-15 18:05:59	2003-09-25 15:53:44	7	50	447	0	346	766	59	117.80	24	54.16	CHANGED	pphsuhLsGsptss.sst...os...........usGpAhhslssss.........sLpa...........plp.hsGL.................ssssts+l.........s.tsppusllhsh................tsst....ssushp...s..lsstphpt.................LhsG....phalslpTpspss.GE..lRGplp	.................................h..h.u.Lsu..tpths..ssp.......op...............usG...pA.hhp...hssst..............pLpa...........plh..hpsl.....................................stsssscl..........ch........s.hsppus..llhtl..........................tsst.hsGsh...p.......t...lsstphpt...................................LhpG.....phalslpTpspPs..GE...lRGpl.......................................................	0	104	190	262
+7281	PF07453	NUMOD1		NUMOD1 domain	Pietrokovski S	anon	Pietrokovski S	Domain	This domain probably represents a DNA-binding helix-turn-helix based on its similarity to other families (Bateman A pers obs).	22.80	13.50	22.80	13.60	22.70	13.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.18	0.73	-7.71	0.73	-3.95	63	326	2012-10-04 14:01:12	2003-09-25 17:24:02	8	37	165	0	53	316	76	36.40	24	17.45	CHANGED	tslhlashssph....l...tpFsSlpcAActLslspss.Isphl	.................lh.hshssph....l....ppFpShpcAuctlslspss.Ipph.............	0	18	39	43
+7282	PF07454	SpoIIP		Stage II sporulation protein P (SpoIIP)	Vella Briffa B	anon	Pfam-B_21650 (release 10.0)	Family	This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation [1]. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex [3]. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity [2].	20.10	20.10	20.50	20.40	19.70	18.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.86	0.70	-5.23	49	584	2012-10-02 19:46:12	2003-09-26 10:34:07	6	5	411	0	125	491	7	270.30	29	71.69	CHANGED	lphpD.....h.shhsp-lshhsthpsphhhstpts..sph..psssshp...pttpt.......................................sspcshVhIYHTHosESYh.P.....t..sssst.....p.slstVGctLsptL.cptGIsshpDcT..ha-h.....saspuYppSRpslpchLpppsshphllDlHRDu....................hp.ppth...sspIsGcshA+lhFVlGpp............sspacpNhphApplpshh-chYPG......Ls+Glhhts.t.....pYNQDLsspAlLlElGu.sNoh-EApposchlA-.lluc	.........................................................................................................................................th.....h.......t....t.tt.....pt.....p.....p...tp.p...................t.....ptt..........p...........................................................sssc.tlhIYHTHotESYh...P.h..........t.sssst.........phNlshVGchLpcpL.cppGIs.shp..DcT.......hpch.......saspSYptS+pslp......c......hLtpstslphhlDlHRDu....................hp...+.phs....oppIsGK.shA+lhFVlGpp................NssaccNhphApplpphhscpYPG......loRGlhhKs..t.....thYNQDLospulLIElGussNTh-EhpposcsLAcshu.p.........	1	67	105	113
+7283	PF07455	Psu		Phage polarity suppression protein (Psu)	Vella Briffa B	anon	Pfam-B_21666 (release 10.0)	Family	This family contains a number of phage polarity suppression proteins (Psu) (approximately 190 residues long). The Psu protein of bacteriophage P4 causes suppression of transcriptional polarity in Escherichia coli by overcoming Rho termination factor activity [1].	21.20	21.20	21.20	21.20	20.10	21.00	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.10	0.71	-4.82	5	269	2009-01-15 18:05:59	2003-09-26 11:05:58	6	1	159	\N	19	169	0	163.10	41	85.17	CHANGED	MTT.VTLQQAF-uCQNNKsAWLsRKsELAAAEQEYcELLhuG-css..sRRLQpLR-lIDVKKWElNQAAGRYIRSHEpVQ+ISIRDRLsDFMQQHGAELAAALAPELMGYppQsshl+psAlQ+SVDYLREALoVWLA......AGEKINYSAQDsDILTsIGFRPDAASRDDNREKFTPAQNhIYoRRRApLAup	...........................................................................................................................................................spphp..Rphl-VhcWplNpAAG+YIpoHctl.cIsh+stLpDFMQpHGsALsuALA..PpLM..G.pp.suhh..hsp..ulpcusshLR-ALhpaLs......pGs....hNYuh.-pD.ILsthGhtPDssuhpDspppaTPAQ..phha....pp+ps.lst...............................................	1	0	3	6
+7284	PF07456	Hpre_diP_synt_I		Heptaprenyl diphosphate synthase component I	Vella Briffa B	anon	Pfam-B_22032 (release 10.0)	Family	This family contains component I of bacterial heptaprenyl diphosphate synthase (EC:2.5.1.30) (approximately 170 residues long). This is one of the two dissociable subunits that form the enzyme, both of which are required for the catalysis of the biosynthesis of the side chain of menaquinone-7 [1].	30.00	30.00	30.30	30.30	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.62	0.71	-4.37	47	636	2012-10-03 02:46:00	2003-09-26 13:39:27	6	4	611	0	123	444	27	143.80	39	79.07	CHANGED	LsuhAlsltllEshIPhPh.h..PGsKLGLANllslluLhh.hu.h+pulhlsllRllluulhtGsh.o.sFhhShAGullShlsMhll.pph.......tcthShlGlSlhGAlhHNlGQLhlAuh.l.....lpshslhhYLPlLhlsGlloGhhhGlhuph....l	...LsA.ulllullEs.hIPhP.hsh..P.GsKLGLANllolluLah...hs.h+-uhhlhhlRl.lLssllsGsl.o.sFhaShuGulLShhsMhll.pph.h.........cp.lSllGlSssGuhhHNlGQLllAuh.l......hpshsl.h.h.YLPlLhhhGlloGlhlGlsush...........................	0	68	110	116
+7285	PF07457	DUF1516		Protein of unknown function (DUF1516)	Vella Briffa B	anon	Pfam-B_22136 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 120 residues long.	29.90	29.90	30.10	31.50	29.70	29.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.67	0.72	-3.97	22	454	2009-01-15 18:05:59	2003-09-26 14:02:50	6	1	435	0	48	197	0	111.10	44	89.66	CHANGED	M...hH.....hHIhoWllhlILFhlAhhhasp...ts+tsKhlHMllRLhYllhlloGhhL...hlpt.......hsshthhhhlKhlhGlhlIuhhEhhls+ppK...t+sopshahhhllslllThhLG	.......M.lHlHIhSWVLulILFlssY.h.hSp...ts.hhKslHMlLRLFhlLsllSGFhl...llpph.....ssuusHMLhsLKMLsGlhVlGlMEhsluK+K+....pc.tops.hahlhI.sllllThhLG.........	0	11	30	41
+7286	PF07458	SPAN-X		Sperm protein associated with nucleus, mapped to X chromosome	Vella Briffa B	anon	Pfam-B_22197 (release 10.0)	Family	This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic [1].	21.90	21.90	23.60	22.40	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.32	0.72	-3.76	9	92	2009-01-15 18:05:59	2003-09-26 15:59:36	7	2	12	0	10	83	1	92.30	49	79.27	CHANGED	M-p.pSSssG.KRpoPC-SNp.tN-pM.ETPstD.sPcPu.KKhKTSE.ST.llVlpYR+phKI...sSspL.NDpSpENsINPlQ.EE-Ehh-hpsEospp	................................M-p.pSSssG..KRp.sPC-SNp.tN.......-......p......M..ETPsts.sP.p.u.KKhKTSE.sT.llVhpYR+shKh...ssspL.NDp.upENpINPlQ.EE-Ehh-...t.st.c.......................................................................................................................	0	10	10	10
+7287	PF07459	CTX_RstB		CTX phage RstB protein	Vella Briffa B	anon	Pfam-B_22203 (release 10.0)	Family	This family contains a number of RstB proteins approximately 120 residues long, including RstB1 and RstB2, from the Vibrio cholerae phage CTX. Functional analyses indicate that rstB2 is required for integration of the CTXphi phage into the V. cholerae chromosome [1].	20.30	20.30	20.90	23.30	18.50	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.59	0.71	-4.23	2	78	2009-01-15 18:05:59	2003-09-26 16:48:33	6	1	49	0	7	34	0	109.50	79	94.27	CHANGED	MKl.........VsFGhSpS.GluppsstPY.I.sLFVGKPIRQWKsDKG.s.s.Ghpp.El.F.SsDthhpKlcphAFPsLVphcsEP.PEDPo+NllIshpVlCoLaDsVPtsK.	.............MKSRFVVFGASHSEGVS.KTG..APYLIPVL.FVGKPIRQWKNDKGQCLTFGLQHQEV..KFVS.SDAMTRKLE..Q..T..A..FPVLVTFDNEPDPEDPSRNLVIDYQVVCSLFDNVPGGKP....................	0	3	4	5
+7288	PF07460	NUMOD3		NUMOD3 motif (2 copies)	Pietrokovski S	anon	Pietrokovski S	Motif	NUMOD3 is a DNA-binding motif found in homing endonucleases and related proteins. It occurs on its own or in tandem repeats in GIY-YIG (Pfam:PF01541) and HTH proteins. It constitutes a beta-turn-loop-helix subregion of the the DNA-binding domain of I-TevI homing endonuclease (Swiss:P13299) [1].	20.40	9.30	20.40	9.30	20.30	9.20	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.98	0.72	-4.06	25	485	2009-12-15 13:13:21	2003-09-27 14:40:31	6	26	140	2	73	456	321	32.80	29	23.99	CHANGED	hGtK+oEEoKpKhSp........h.ttshhGKp+o-Eo.KpKlSc	................................h.hoc-s+p+hSp.................t.tps.hhGKp.t...otEs.+thhp................	0	37	62	68
+7289	PF07461	NADase_NGA		Nicotine adenine dinucleotide glycohydrolase (NADase)	Moxon SJ	anon	Pfam-B_21586 (release 10.0)	Family	This family consists of several bacterial nicotine adenine dinucleotide glycohydrolase (NGA) proteins which appear to be specific to Streptococcus pyogenes. NAD glycohydrolase (NADase) is a potential virulence factor. Streptococcal NADase may contribute to virulence by its ability to cleave beta-NAD at the ribose-nicotinamide bond, depleting intracellular NAD pools and producing the potent vasoactive compound nicotinamide [1].	28.50	28.50	29.00	31.80	25.60	28.40	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.43	0.70	-5.80	2	89	2009-01-15 18:05:59	2003-09-29 10:54:18	6	1	32	2	4	78	0	423.80	87	95.30	CHANGED	MRNKKVTLAHIVAKTSVAIALAGAMGSSLLANSTTYAVSGKENKKSDVKYETTKVMEANATSSKEDNHVMHTLDGSMSTVWEENSPGGGVGEVLSYKFsSPM+IGRILIVNGDTSSKENYYKKNRIAKADVKYYNtNKLVLFpKIELGDTYTKKPHHIEIDKKLDVDRIDIEVTEVHQGQNKDILALSEVTFGNhERDlFEKKFKEIKDKWVTDKQADEFIETADKYADKAlQMSAVASRAEYYRMYVSRKYHYKKEFVEKLKQVYKESGASHVTSKKDLMLAFDDAK+KSTIGRQENGLFVTSFAEDMALLFTDQGKLKSADQIENIKGVDSGKYSDGVYQYEYDSELTKNIDKLGYIRTASGDTPGANSLNIPGCQTWSGKHIENSESELIFPSISVKDLKSKAVLAEIDAKGYFEIIDPTIIAPNGDHKKVTGRFKIKKMQDR	..........................MRNKKVTLAHIVAKTSVAIALAGAMGSSLLANSTTYAVSGKENKKS..DVKY.........ET.TKV..MEANATSSKEDNHVM...HTLDGSMSTVWEENSPGG.GVGEVLSYKFASPM+IGRILIVNGDTSSKENYYKKNRIAKADVKYYNGNKLVLFQKIELGDTYTKKPHHIEIDKKLDVDRIDIEVTEVHQGQNKDILALSEVTFGNhERDlFEKKFKEI...KDKWVTDKQADEFIETADKYADKAVQMSAVASRAEYYRMYVSRKYHYKKEFVEKLKQVYKESGASHVTSKKDLM.LAFDDAK+KSTIGR..Q...ENGLFVTSFAEDMALLFTDQGKLKSADQIENIKGVDSGKYSDGVYQYEYDSELTKNIDKLGYIRTASGDTPGANSLNIPGCQTWSGKHIENSESELIFPSISVKDLKSKAVLAEIDAKGYFEIIDPTIIAPNGDH.KKVTGRFKIKKMQDR.....................................................	0	1	2	2
+7290	PF07462	MSP1_C		Merozoite surface protein 1 (MSP1) C-terminus	Moxon SJ	anon	Pfam-B_21542 (release 10.0)	Family	This family represents the C-terminal region of merozoite surface protein 1 (MSP1) which are found in a number of Plasmodium species. MSP-1 is a 200-kDa protein expressed on the surface of the P. vivax merozoite. MSP-1 of Plasmodium species is synthesised as a high-molecular-weight precursor and then processed into several fragments. At the time of red cell invasion by the merozoite, only the 19-kDa C-terminal fragment (MSP-119), which contains two epidermal growth factor-like domains, remains on the surface. Antibodies against MSP-119 inhibit merozoite entry into red cells, and immunisation with MSP-119 protects monkeys from challenging infections. Hence, MSP-119 is considered a promising vaccine candidate [1].	20.40	20.40	20.50	20.40	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.96	0.70	-6.12	4	835	2009-01-15 18:05:59	2003-09-29 11:07:15	6	6	34	0	10	628	1	341.40	56	39.29	CHANGED	Shss+uESE--h.ssshEl-phYcsaLpplDs..NspFhpFlKSKK-lIsuLT.pKhNtLhhEIt+LK-h.ph.aD+YhKYKLKLERLapK+cpIpsuppQIKcLolLKs+L.+Rpp.lNssa.VLpsassFFNK+REAEKp.V-NsLKNT-hLLKYYKARsKYasuEusPLKTLocsSlp+EsNYLplEKFRshSRLEhRLpKNIpLGKE+ISYlSuGLHHVhpEhKEllKNKsYTGposs-NsscVpcAhcpYcELLPKssTtpAssss.ssTPsssssussstusssuuuuGuuuGpssssTstpl...G.utss......................Vlsh.ussDDDD--hDQlsoGpupstp.csILsAFcsE.-hlYhKsLussYKSlKKph.+chsshppslsshLNs+LcKRN.FL-VLsp-Ls.FKclSoNcYlI+sPYpLLDs-KKcK.lhshKYhtcuVscDIcTAsDGIpaaNKMlELYKspLsAVpcQIctltst.ss..c-cKK......................KYlPhhpsLcsLYEollsps--Yh-sLpp+lsshplEKsEh-	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................A..o...s..-..llssh.s-Y-VlY.LKPLAGMYKoIKKQLENHVsAFNTNITDMLDSRLKKRNYFL-VLsSDLNPFKYSS.SGEYIIKDPYKLLDLEKKKKLlGSYKYIusSIDhDlsTANDGluYYNKMt-LYKscLsuVpppIKclEsph.t..-ch..cKh.........spsspss.p.sp.hAcKtE.cKYLPFLNSlpKEYEoLVsKlsoYopN.LKKhIsNCQlEK+EAE............................................	2	1	2	7
+7291	PF07463	NUMOD4		NUMOD4 motif	Pietrokovski S	anon	Pietrokovski S	Motif	NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related proteins [1].	23.40	23.40	23.50	23.50	23.00	23.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.47	0.72	-4.08	55	364	2009-09-11 07:03:11	2003-09-29 11:41:44	6	21	293	1	46	303	100	52.20	30	27.43	CHANGED	EhWKsI...G.acs...YpVSshGRV+S..................hpps+lLp.ths...sGY..hhVsLt.ps	.......EhW+sIt.....u..a-s.....Ypl..SshG.+V+o..................htps+lL+sphs..t..sGYhhVsLh...........................................................	0	13	30	37
+7292	PF07464	ApoLp-III		Apolipophorin-III precursor (apoLp-III)	Moxon SJ	anon	Pfam-B_31170 (release 10.0)	Family	This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage [1].	31.00	31.00	31.00	31.50	30.90	30.90	hmmbuild  --amino -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.16	0.71	-4.20	8	45	2009-01-15 18:05:59	2003-09-29 14:54:15	6	2	36	1	18	50	0	143.30	27	77.83	CHANGED	lEKHAtEFQKTFSEQhNulsNS..KssQ-VNKAlK-GSDSVLQQLssluoSLQuAlsDANGKAKEALEQsRpNlE+TAEELRKAHPDVE+pAspLRD+LQAAVQuTlQEoQKLAKEVuuNh-ETN-KLAPpIKpAYDD...FVKpsEEVQKKlHEAAoKQ	...............................pht-h.pshppphpphhs.......pssp-lscslK-socshlpplpshtsslpstlpc.ssschcpslcphppplpcTsccLpc..s.pP-lpcpAspLpp+lQsulQshspEspKluKclupssppss-cLsstlKpsaDs...hscsspclpcclppAsp..............	0	4	8	17
+7293	PF07465	PsaM		Photosystem I protein M (PsaM)	Moxon SJ	anon	Pfam-B_21548 (release 10.0)	Family	This family consists of several plant and cyanobacterial photosystem I protein M (PsaM) sequences. PsaM forms part of the photosystem I complex and its binding is stabilised by PsaI [1].	20.80	20.80	20.90	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.52	0.72	-7.03	0.72	-4.34	40	300	2009-01-15 18:05:59	2003-09-29 15:43:26	8	1	285	2	33	181	1	28.70	48	91.33	CHANGED	IoDoQIalALllALlsulLAlRLGppLY+	............l.-sQlllAL..hlAhhsulLAl+LGpsLYp..	0	12	24	31
+7294	PF07466	DUF1517		Protein of unknown function (DUF1517)	Moxon SJ	anon	Pfam-B_22018 (release 10.0)	Family	This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.98	0.70	-5.42	27	295	2009-01-15 18:05:59	2003-09-29 15:46:33	6	6	196	0	143	297	48	193.10	20	68.03	CHANGED	tAtSGGRIGGGSFp.uP.......SsPpo.ss.suuhh..................GGGhGaPFllPh......aGhGG.G..GLFuhLlhhulsshllpshRssttt...........ssttst.hssstVolsplQVGLLApA+sLQpDLpplAtpADTsossGLppVLQEsoLALLRpP-hWVYusscss.pssh....suAEu....pFNpLolpERSKhspEohSNlssppppsstst.ss.s.t.........-sssEYIlVTlLVAucupl.pLPt.lsous-LRpALptLGulsuscLlAlEVlWoPpscGDsLot-ELlssYPpLphL	.....................................................................................h....uGt..GGt.uFt..ts.............s.ss.pt..t.tsss......................t......................us...hhs...hs.hhsh...............................hGhuh....t....t...h...hs.h.l....lhhhlshhlh.thhpt..............................................................................................................................................................................................................................................................................................................................................................................................	1	31	88	132
+7295	PF07467	BLIP		Beta-lactamase inhibitor (BLIP)	Finn RD	anon	Pfam-B_41444 (release 10.0)	Family	The structure of BLIP reveals two structural domains, which form a polar, concave surface that docks onto a predominantly polar, convex protrusion on beta-lactamase. The ability of BLIP to adapt to a variety of class A beta-lactamases is thought to be due to flexibility between these two domains [1].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.16	0.71	-4.63	3	21	2012-10-01 23:09:26	2003-09-29 16:55:43	6	1	15	29	4	43	0	132.40	29	91.48	CHANGED	VK.RluRouluLsAAAGAVLATAoSApAsoGFTuEKYsQIQFGMTRspVW-IAGAEtuC-TGGshGDSIlCasc.uGDYuPYGsFuFTuA...uKLhSKRQEcLasAssPTl+LA+YN+TslGMTEAQlWAAVPpDSCoohuEpYPNWPATsGspccYsC.....sSuTGhFsPSAaFaFTDGVLTuRpQpsL	.................h.....................hll..A..sshuhs.AsothTsEpYppIphGMspsEVhsllG..ut.ss...C.s-..ss..h..................................................................................................................................................................................................	1	1	1	3
+7296	PF07468	Agglutinin		Agglutinin	Finn RD	anon	Pfam-B_57133 (release 10.0)	Family	\N	25.00	25.00	27.50	25.80	23.20	17.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.00	0.71	-4.23	2	39	2012-10-02 19:42:32	2003-10-03 15:43:28	6	5	9	8	23	50	0	139.20	29	55.88	CHANGED	hthPhhhshhpsNNtKYLth.o..IpQhshLQFuhDpl.DPhstaph.s..T.sGhlpIKSpYhNKahhh.osN..WIhssuN-PcE..oN.AssLF+s...-.tshphlpLLphQhsaahcpaTsGts.Flshh.Atop.lDpsu..lhclI-	..................................................hlhhpssNscYLphhs....hp..thshLpFuu--lsDPhstapl.s..s..tcG..hV+I+ssahsKaW+.c.....o...sN........WIhAsus-scp..os.ssTLFcPlhl.-.tphp.hlthpphttspaspphs......hsCL.Ass..tp.p...............................................	0	0	11	23
+7297	PF07469	DUF1518		Domain of unknown function (DUF1518) 	Finn RD	anon	Pfam-B_1525 (release 10.0)	Domain	This domain, which is usually found tandemly repeated, is found various receptor co-activating proteins.	25.00	25.00	28.90	28.90	24.20	23.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.85	0.72	-3.82	17	247	2009-01-15 18:05:59	2003-10-06 13:27:18	7	13	39	0	91	216	0	57.30	44	5.65	CHANGED	uhsuthussthPQussQQFPasPNYGhuQQs-PuFssuhSP.SshMSsphu.oQSsMh	...uhsuphusPthPQussQQFPYPPNYG..h..up..Qs-PuFsssh.SP.oshhssphssoQssMh...........	0	4	9	29
+7298	PF07470	Glyco_hydro_88		Glycosyl Hydrolase Family 88	Finn RD	anon	Pfam-B_10896 (release 10.0)	Family	Unsaturated glucuronyl hydrolase catalyses the hydrolytic release of  unsaturated glucuronic acids from oligosaccharides (EC:3.2.1.-) produced by the reactions of polysaccharide lyases [1]. 	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.22	0.70	-5.40	19	2447	2012-10-03 02:33:51	2003-10-06 14:06:07	8	26	1025	25	672	2054	111	336.70	21	81.37	CHANGED	hhc+hspthh.c.s..........h......c........WspGlhhtG.hh.tsa-hTtccc....Yhphsps..........ascphhccssp..................hplDphshGhhh....hh....lYchst.Dpchhtsshpht-.lltphs+htcGshh+.....tph..hphW.............lDsLaMusPhhhph....uphhs-...cah-cshppahhptcp.................hhDscsGLaa+uac....pspp.hus........hWuRupGWhhhulschlch......LPp.pcss+p.lhplhpshs.ps.lt+hQc.psGhWapllccss...shhEoSuoAhhlYulh+ul............ppGh....l.scpYtpssp+uacullcp...........lpc-Gphhlppsssssuhst............YtshshtpspsaG.GhhlhAhhEhh+hh	...........................................................................................................h......................................tt...p..............Ws.pGhhhhG...hh..hha....c....ho....t....c....pp..............hh.ph..s.pp.........................hh.p.p.h..h..t..phsp.............................phpl.s.p...h..s.h.G.h..h.h.............hh............hY....c.....h.........s........s....s........t........ph..tp.h...h..h.phA-......hhp...p..h.........p.........t.....p.G...s..h..hp...............................tp.t..p.tpha.............................lDsl..hM..sl....h..L.h.hh...................uphs....s..c.t......ca.h.-..Ahpphh..hp..hpp..................................hh.D.s...c...o.....Ghh..h.+..uhs........t..p.u..h......p..s.us................................hWuRGpuWshhuh..sthhch...............l.......p....p........p......s......t........t...p.......h.......h.......h.......p......h.hpt....hh..pt..l.......h..c......h...............c....p........s..u.....h...W.....p........h............h....h........s.....c.......s...........s.......................s.........................h-oSAoA.hh...shu....l...h..p..tl...................................pp.th..............h.......t.....p...p....Y.....t...p....s....s...pc....t...hpulhpp...................hs.t....s....G..p............l..t...t.s.hhh.pu...t.................................p.sh...s...h..s.s................aG.shhal.Ahhch....h..............................................................................................................................................................................	0	272	506	604
+7299	PF07471	Phage_Nu1		Phage DNA packaging protein Nu1	Finn RD	anon	Pfam-B_11430 (release 10.0)	Family	Terminase, the DNA packaging enzyme of bacteriophage lambda, is a  heteromultimer composed of subunits Nu1 and A.  The smaller  Nu1 terminase subunit has  a low-affinity ATPase stimulated by non-specific DNA [1]. 	30.00	30.00	30.30	30.20	29.90	29.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.96	0.71	-4.77	11	762	2010-01-12 09:52:22	2003-10-06 14:22:59	7	4	374	2	31	345	35	138.20	50	83.26	CHANGED	McVNKKpLA-IFGsulRTIppWQcQGhPVl+GGGKGsEslaDoAuVI+WYA-R-AEIENEKLR+EVEELRtAuEsDLpPGTI-YER+RLTRAQADAQELKNA+-suEVVETAFCTFVLSRIAuEIuSILDGIPLSlQRRF..PELENRHlDFLKpDIIKAMNKAAA	.................................................................lNK+phAc.hsss.pshppW.t....p....Ps.p.......K.G..EshaDsAssIp...hpR.cs..p..c..s..p+Lp.c-.ht-...lct..s.s.pt....D..ps..spl.h..tRaRL.TcAQA-AQE..LKNs.+-pucVl-TsFChFsLS+lAtpIuSILD.u.lPLohQRpF..P-LpsRHlDhLKp-IhKAhNpuA.........................................................................	0	8	18	28
+7300	PF07472	PA-IIL		Fucose-binding lectin II (PA-IIL)	Finn RD	anon	Pfam-B_17609 (release 10.0)	Family	In Pseudomonas aeruginosa the fucose-binding lectin II (PA-IIL) contributes to the pathogenic virulence of the bacterium. PA-IIL functions as a tetramer when binding fucose. Each monomer is comprised of a nine-stranded, antiparallel beta-sandwich arrangement and contains two calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions [1].	20.90	20.90	20.90	22.40	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.15	0.72	-3.83	12	85	2009-01-15 18:05:59	2003-10-06 15:00:50	6	5	53	100	25	63	2	108.60	48	54.85	CHANGED	FpLPsshcFGlTAasNou.tpQTlcValDDp.t..sTasGpGssss.huTpslsSG.sG+Vplpl.usGKPScLtup.ssLss........KsshullGuEsGsDsD..YNDulVlLNWPL	...........FsLPsNhpFGlTAasNou.spQTIcValssssp..ATFpGsuoss.....s........luTplLNSG..sGKVplpVosNG..KPScLsSpQsslss........cssFu..lVGSEDGoDsD..YNDulVVLNWPL....	0	2	9	15
+7301	PF07473	Toxin_11		Spasmodic peptide gm9a	Moxon SJ	anon	Pfam-B_90829 (release 10.0)	Family	This family consists of several spasmodic peptide gm9a sequences. Conotoxin gm9a is a putative 27-residue polypeptide encoded by Conus gloriamaris and is known to be a homologue of the "spasmodic peptide", tx9a, isolated from the venom of the mollusk-hunting cone shell Conus textile [1]. Upon injection of this venom component, normal mice are converted into behavioural phenocopies of a well-known mutant, the spasmodic mouse [2].	25.00	25.00	33.40	33.40	21.50	20.30	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.67	0.72	-4.02	2	4	2012-10-01 22:06:18	2003-10-06 16:07:17	6	1	4	1	0	5	0	27.50	46	37.54	CHANGED	.CspuCpS.scCsp+ChCp.ctpsshpt	..CNNSCQpHScCsSHClCphctCssVNt	0	0	0	0
+7302	PF07474	G2F		G2F domain	Bateman A	anon	Bateman A	Domain	Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein Pfam:PF01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.	23.50	23.50	23.60	25.40	21.10	23.40	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.16	0.71	-4.93	5	296	2012-10-01 21:32:51	2003-10-27 12:53:42	7	164	81	2	160	235	0	182.50	35	9.46	CHANGED	cGuPQRlNGpVpGpIpVls.c...hslsFsssDLHuYlVos-GRuaTAIS.slPpsLGpuLpPlssIGGllGWLFAcEp.ssuhNGFoLTGGpFsRcspVcF..csG..clpIcQpacGlDs-.....saLsl+hslcGpVPpIsssuoVpIcDYoEhYppotsGllTSpSTRsaTVcs.....uu.spTasYolDQTITF-pCpc+.scls	......................................................GsPpRspGpltGplpss...p....hslsh.ssslps.sssssuph.aouIo.....p.lPpslG..uhhsLsslhuslhWhhAhE..ssshNGFo....lT...G..utFp+pspVpF...tsG...EhLplsQphcGLDsc.......shLhlcs.lpGpV.Pplsssuslplp.sYpE.Yh.o.su........lhutSoRpas.l.st...........tshsYphppsIpYppsttt....s................................	0	26	38	83
+7303	PF07475	Hpr_kinase_C		HPr Serine kinase C-terminal domain	Bashton M, Bateman A, Moxon SJ	anon	COGs	Domain	This family represents the C terminal kinase domain of Hpr Serine/threonine kinase PtsK.  This kinase is  the sensor in a multicomponent phosphorelay system in control of carbon  catabolic repression in bacteria [1].  This kinase in unusual in that it  recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating  enzymes [1]. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller [2].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.79	0.71	-4.95	81	2208	2012-10-02 15:24:17	2003-10-28 16:53:30	7	7	2083	29	470	1375	236	159.20	43	53.76	CHANGED	ppLAsppslHGVLlDVaGlGVLIpGcSGlGKSEsALELlcRGH.RLVADDsV-lpchsppt.LhGp.uPcllcchlElRGlGIIslpsLFGhsul+spppIpLllpLppWcpp..ppaDRLGh-.ppptcILslclPplplPVcsGRNlAlIIEsAAhNa+hKphG.asuscpFpcRl	...................t.pLA.psolHG.VLlDla.Gh....G....VLIpG-SGlGKSEsAL........E........L....l.......c......R......G......H.......R......LVADD.........tV.-l...h.........p...h.sc.p............p...Lh.Gp........s...P..c...l...l.ca....L.l...E.I..RGlGIIsVhsLaGsuul+sppplpLslpLcpappp........ctaDRLG...p.p..p..p.hclh.s.splsplplPV+sGRNlulllEsAAhNaRhp..hG.hsssppFtcR...................................................................	0	158	314	385
+7304	PF07476	MAAL_C		Methylaspartate ammonia-lyase C-terminus	Bateman A, Moxon SJ	anon	COG3799	Family	Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the C-terminal region of Methylaspartate ammonia-lyase and contains a TIM barrel fold similar to the Pfam:PF01188. This family represents the catalytic domain and contains a metal binding site [2].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.55	0.70	-5.45	14	185	2012-10-02 01:07:48	2003-10-28 16:58:51	6	4	176	12	41	2518	572	245.40	60	60.15	CHANGED	slshcslPlFuQoGD-RYhNsDKhIlKcs-VLPHuLhNsV-.KlG.cGEcLh-YlpWLppRlhpL.uscsYpPhlHlDVYGTlGthFss..Dhc+hs-YLupLccuAtPatLpIEGPhDsGs+ttQIctLstLRptLccpGlsVclVADEWCNThEDI+tFsDupAucMVQIKTPDLGGlsNol-AlLYC+c+GlGAYlGGoCNETDhSAclssHlALAspPsQhLuKPGMGlDEGlMIlpNEMpRslAlhcp	.....................................................................................................s..sEsIPlFGQSGDDRYlsVDKMILKGlDVLPHALINNVE-KLGh+GEKLtEYVcWLu-RIlsh.RsuscY.+.PsLHI.D.V.....YGT...IGllF-h..Ds......hRsApYIAoL.EcpApshs.L.h.I.EG.PlDAG.sK.s.cQIchLsuls.ccLs.+hGos.....V+IVA.DE.W.C.NT.a.p.D....I.h.-.F.sDAsusHMVQIKTPDLG.uIcNllDAVLYCpp+uhpAY.pGGTCNETDlSARsCVHVALAsRPhpMLsKPGMGFDEGl.IVaNEMNRTlALLp.s...........................................	2	16	26	35
+7305	PF07477	Glyco_hydro_67C		Glycosyl hydrolase family 67 C-terminus	Finn RD, Moxon SJ	anon	CAZY	Domain	Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the C terminal region of alpha-glucuronidase which is mainly alpha-helical. It wraps around the catalytic domain (Pfam:PF07488), making additional interactions both with the N-terminal domain (Pfam:PF03648) of its parent monomer and also forming the majority of the dimer-surface with the equivalent C-terminal domain of the other monomer of the dimer [1].	20.30	20.30	20.80	28.80	19.30	19.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.52	0.70	-4.95	38	293	2010-01-08 16:36:07	2003-10-29 13:35:56	7	7	257	17	125	306	20	220.20	42	31.06	CHANGED	oGphhAQANhYuaGRLAWsPshsocpIscEWlRhTF.......us.cpcVlcslsp............hhhpSapAa.sY.ssPLGlpahsshs....a.HYGPsPtsp-tss......Wus..YH+ADcsGIGhDRT.poGoG...hsuQYss.lAcha-slcTsP--LLLWFHHVPasa+L+SG+TllQclYcp+acGscpVpshhpsWcuLcutlDscRapcVtt+LphQtpcAhhWRDuhssYFhphSG..IP-thsRst.a	..................................sGp.hAQANhYAaGRLAWsPslsucpIscEWl+hTF...............us.-.tpl.....lcslpp................hhhpShcsh.sY.psPLGltahhs.s.....+..HYGPsPts.c.hst....................Wss......YH+ADppGIGhDRT.uo..G..os...hsuQYhs.lspha-slposP-cLLLaFHHVPasa+L+S..G+T...lhpclhspahcGlcpspphhppWp.s.Lcs..h..l...D.s..........c..........RapcVtp+LphQtccAh.WRDshssYF.phSG..IPsthtR..............	0	42	84	108
+7306	PF07478	Dala_Dala_lig_C		D-ala D-ala ligase C-terminus	Bateman A, Moxon SJ	anon	PSI-BLAST 2dln	Family	This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF) [3].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.90	0.71	-4.93	18	6597	2012-10-10 13:17:03	2003-10-29 13:51:30	8	33	4445	68	1275	21237	8280	190.70	33	59.00	CHANGED	LhpssGlssssahslp+pchppts......htph.tpLGaPlFVKPAptGSSlGloKVpst-ELpsAlcpAhpYDpcVllEcsl.sGcElpsulLG..Nts.hplussscIthss......uFYDYcsKY....s.ssuphhlPAsLstphppplpchAhcsY+sLus+GhARlDFFL.spcGplhLNElNThPGFTshShaPphhtssGlsascLlspLlp	............................................................................................................hpstGl.sh.ss..a..h...s.l.pp.sp.....p.t....................t.h.....p..p....L..s.h.....P.l.h.VK..P..u..p....t..G..S........S..l.....G.....l.....o....K.....V.......p....s.......p.......p.......p......L.......p.......t........A......l........c..........h.........A...........h..........p............a...........D.........p..............c.............V......l......l..Ep.hl.....s.G...........c......El...p...s...u....l..L.G...........p....tt......sp...s...h......s...s...s..E...I..h.h..ss...........................sF...Y..D...Y...-..u.K...Y...........................................s.....s.....p...........s.....p...h.........h.......h......P.........A.....p.................l.......s......s.........c.........h..t...p...p.....l..pp..hAhp.Aa..p.....s.....L.......s......s....p.......G....h...u..R.l...D..................h.....h........l.......s................t............c.........s........p.....h......h..l.E..lN.....T.hP.....G..h.....T.........s.....h.........S.h.........h.Ph.........h.........h.p.s.s.G.lsaspLlpcll......................................................................................................................	0	456	861	1094
+7307	PF07479	NAD_Gly3P_dh_C		NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	Finn RD, Bateman A, Moxon SJ	anon	Prosite	Domain	NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain [2].	25.00	25.00	27.20	26.30	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.81	0.71	-4.49	27	5512	2012-10-02 19:36:47	2003-10-29 14:12:16	9	20	4754	22	1400	3895	2018	143.50	41	42.43	CHANGED	sDlhGVElsGALKNVlAlAsGhsDG......luhG.....sNsKuullphGLhEhp+huthhssssp....Taht.sGluDLlsTChu..uRNp+hGptlu+s...pshcplpcph.......GthlpGstTscplhplhpppsl...............chPlhpslYpllhpthpspchlppL	.............sDllGVEluGAlK.............NllAluAGhs.cG...........l.G..hG..........sNu+.......AALlTRGL......sEhsRlG........s...s...h...Gupst.................TF.h.G.LuG..lGDLllTCou.....S..R............Nh+hGhtLGpG...............pslcph.pph.....................GtVlEGh....tosc...sl....h.p..lAc.c..h.sl...............cMPIspslap.lLap.stssccsh...h...........................	0	469	881	1177
+7309	PF07481	DUF1521		Domain of Unknown Function (DUF1521)	Yeats C	anon	Yeats C	Family	This family of unknown function is found in a limited  set of Bradyrhizobium proteins. There appears to be a periodic -DG- motif in it.	21.00	21.00	22.40	22.20	20.60	19.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.22	0.71	-4.55	5	27	2009-01-15 18:05:59	2003-11-03 12:43:51	6	2	16	0	10	27	0	155.60	39	56.14	CHANGED	WSH.EV+DGKATIcLGDKYoIslDEKDGThplRNsQTG+lT+I+GDPHVDANGDGKcDFDFKKsMTFQLDDGTKITVDTVsYGp..GcTlASKLTITNGDNAMVVEGLGDccDGKNNL+VTQSNAGRTLDpLTsDGAQTIaEtoGpGWVDs.oG+tVTQAsIstsEsssssushp	....................ppupupIphsDtYoIpss-psushplpNsp.TGcsT.plaGDPHVDssGDGcssFDFK+shTFpL-DGTKITVsTssaGs..GtTloS+LTITsGcs.uhhVpGlscsc..pssLplppu.ssGhhlD.hssDG.phh.p..sstGal..s...tGt...ssQt.hs.sc.........t......................................................	0	5	6	8
+7310	PF07482	DUF1522		Domain of Unknown Function (DUF1522)	Yeats C	anon	Yeats C	Family	\N	25.00	25.00	25.00	111.30	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.40	0.72	-3.90	20	54	2009-01-15 18:05:59	2003-11-03 16:03:44	6	2	9	0	40	58	0	111.70	54	27.03	CHANGED	oTLsVNGKTITFKsussPsuu...slssGSGls..GNllTDGsGNSTVYLss......ATVsDlLsAIDLAoGVpoATl.usGsATlussu.....GssuS...hsuuGsLsLsTuTGuDLSIo.Gsush	.oTLsVNGKTITFKsussPsus...slsoGoGls..GNlhTDGsGNSTVYLts......uTVsDVLpAIDLAoGV+oAol.usGsATluTus.....GsssS...ssuuGtlpLsououADLolTGsush.....	0	8	14	20
+7311	PF07483	W_rich_C		Tryptophan-rich Synechocystis species C-terminal domain	Yeats C	anon	Yeats C	Family	This domain is found at the C-terminus, normally between 2-3 copies, of a range of Synechocystis membrane proteins. This domain is fairly tryptophan rich as well. 	20.70	20.70	21.20	20.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.52	0.72	-4.37	14	123	2009-01-15 18:05:59	2003-11-03 16:47:07	6	23	22	0	33	93	105	104.40	32	17.49	CHANGED	s.sTSLlttsssYahs.hssGosstLKYsGtshssGpFGshsPluA.pTusG.apVsWpssuTspaohWsTDuNGNahSp.oshVsGsShps.shEssFtpDlNGDGslG	............................thulltt..shahs.husssssslKat.G.ps.hssuphGsWpsl..uA.ET.ssGh.QVLWp..sss...ssphsVWsoDuNhNalu..Ssshss.sSsphhshEssFphDlNsDuhlG...................	0	13	20	20
+7312	PF07484	Collar		Phage Tail Collar Domain	Yeats C	anon	Yeats C	Domain	This region is occasionally found in conjunction with Pfam:PF03335. Most of the family appear to be phage tail proteins; however some appear to be involved in other processes. For instance Swiss:Q03314 from Rhizobium leguminosarum may be involved in plant-microbe interactions ([1]). A related protein Swiss:Q9L3N1 is involved in the pathogenicity of Microcystis aeruginosa. The finding of this family in a structural component of the phage tail fibre baseplate (Swiss:P10930) suggests that its function is structural rather than enzymatic. Structural studies show this region consists of a helix and a loop ([2]) and three beta-strands. This alignment does not catch the third strand as it is separated from the rest of the structure by around 100 residues. This strand is conserved in homologues but the intervening sequence is not. Much of the function of Swiss:P10930 appears to reside in this intervening region. In the tertiary structure of the phage baseplate this domain forms part of the 'collar'. The domain may bind SO4, however the residues accredited with this vary between the PDB file and the Swiss-Prot entry. The long unconserved region maybe due to domain swapping in and out of a loop or reflective of rapid evolution. 	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.77	0.72	-4.18	181	1934	2009-01-15 18:05:59	2003-11-03 17:20:07	7	82	865	5	447	1768	405	51.40	41	13.56	CHANGED	GpIhhauhs......hs........P.........pG.....WhhCsGphlshsp...ssLau...llGshaG.Gs..GtsoFsLPDLRGchs	..........................GsslsaP.us......ss.........P...................................sG............ahhssGp...sa.st.sp...YPpLhs........................................u.........hso.......h..sLPDhRGhh......................	0	134	266	347
+7313	PF07485	DUF1529	DUF1259; 	Domain of Unknown Function (DUF1259)	Yeats C	anon	Yeats C	Family	This family is the lppY/lpqO homologue family.	25.00	25.00	27.20	27.10	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.50	0.71	-4.38	43	461	2009-01-15 18:05:59	2003-11-04 10:36:12	6	3	198	0	107	299	12	120.00	35	80.42	CHANGED	ss.plsplLGpKGshs..sGVa+lshsRtDlplshpGhslss.s..hulsshhuFps.sss.spAhhhGDhVLlpcEVsPVhpsLppsGIpVTAlHNHhLt-pP+lhahHhtuhscsscLApsl+sALcth	...........ttlsphLG.ppGphs..sulh+hslsRpDhplphpGhplss..s..hulsohhuFps...sss.GcAhlhGDhVlhpcElssVhpulpstGIploAlHNHhLp-pPplaahHhtuhs.DsssLA+sl+sAL-t.......	0	45	78	91
+7314	PF07486	Hydrolase_2		Cell Wall Hydrolase	Yeats C	anon	Yeats C	Family	These enzymes have been implicated in cell wall hydrolysis, most extensively in Bacillus subtilis. For instance Swiss:P50739 is expressed during sporulation as an inactive form and then deposited on the cell outer cortex. During germination the the enzyme is activated and hydrolyses the cortex([1]). A similar role is carried out by the partially redundant Swiss:P42249 ([2]). It is not clear  whether these enzymes are amidases or peptidases.	21.70	21.70	21.70	21.90	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.71	0.72	-3.53	170	1705	2009-01-15 18:05:59	2003-11-05 10:54:44	7	29	750	0	448	1369	387	105.20	32	42.38	CHANGED	cGEshpGplAVAsVllNRV.c......sspFPs..olsuVlaQs.........QFohs.ss.......................Gph.p.h........ssp....puhc...sApps.L..sGt...sssssAhaa..as.sts..s.s.p...Wh...shphsspIGsHhFac	...........tGEshpGplAVusVllNRV..c..........ss.p.FPs.......olssVlaQs.......stFsss.ss..............................................................Gphth..........sp.....pshp....sAccs.l........sGt.................s.....ss.s...........sAlaa..assts......s...s..p...........Wh.....st.hh...tplGpHhFhp..............................................................	0	191	328	375
+7315	PF07487	SopE_GEF		SopE GEF domain	Finn RD, Moxon SJ	anon	Pfam-B_18665 (release 7.8)	Domain	This family represents the C-terminal guanine nucleotide exchange factor (GEF) domain of SopE. Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, can activate Cdc42, an essential component of the host cellular signaling cascade, in a Dbl-like fashion despite its lack of sequence similarity to Dbl-like proteins, the Rho-specific eukaryotic guanine nucleotide exchange factors [1].	19.60	19.60	20.80	22.60	18.70	16.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-10.86	0.71	-4.28	2	188	2009-01-15 18:05:59	2003-11-05 11:19:39	8	3	146	6	6	80	0	160.40	71	70.50	CHANGED	AVLTsKsVKDFMLQpLNslDI+GsASKDPAYApQTpEAILSAVYSpNKDQCCpLLISKGlsIsPFLpEIGEAApNAGLPGphKNsVFTPuGAGANPFlsPLIuSAs.KYP+MFINppQQsSFKhYAEKIlMpEVsPLFNcssMPTPQQFQLhlENIANKYlQNss	........................AVLTsKsVKDFMLQpLNslDI+GNASKDPAYARQTCEAILuAVYSNNKDQCCKLLISKGlSITP.FLKEIGEAAQNAGLPGE.hKNGVFTPGGAGANPFVlPLIAuASlKYP.HMFINH..NQQVSFKAaAEKIlMKEVsPLFNcsoMPTPQQFQLTlENIANKYLQNAS............................................................	0	3	3	4
+7316	PF07488	Glyco_hydro_67M		Glycosyl hydrolase family 67 middle domain	Finn RD, Moxon SJ	anon	CAZY	Domain	Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans.  This family represents the central catalytic domain of alpha-glucuronidase [1].	20.30	20.30	21.30	21.30	17.90	19.60	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.83	0.70	-5.54	37	290	2010-01-08 16:36:33	2003-11-10 10:33:56	7	7	257	17	125	302	12	316.00	52	44.22	CHANGED	L+hltput....slssls.........hhpsPpstlRhlNcW....DNlD......GolERGYAGtSIFahs...................shsths.sRhtpYARhLASlGINulVlNNVNAps......plLospalpcluplADlFRPYGI+laLSlNFASPhp....lGG...LsTuDPLD.cVhsWWpppsscIY.phIPDFGGFLVKAsSEGQPGPhs.YGRTHA-GANMLAcALpPaGGlVhWRAFVYsp...p.p.-hpsDRA+uAY-pFpPLDGpFcDNVllQIKNGPIDFQVREPsSPLFGuh.+TshhlEhQITQEYLGQpsHLsYLsPhWc...ElLcaDsascGcs.SpVtcllsG..ph....aspphuGhAGVuNlGsDpNW	..................t.ttshppls.htpsPphtlRhlNHW....DN.hD......GolERGYAG...t..S..lahhs....................sh....th...sRhpcYARh.ASlGINusV...lNNVNups................phLospaLp.clu.tlA-lFRPYGI+laLSlNFuuPhp...............l....GG........L..sTuDPLD.pVtpWWcppsccIY.ph.IPDFGGFLVKA.sSEGQ..PGPhs.YG..RoHADGANMLAcAL....tP..a.G...GlVhWRAFVYs.......p-p...............psDRA+tAYccFpPLD.........GpFcDNVllQlKNGPlDFQsREPhSPLF.Guh.+TshhlEhQITQEYLGQppHLsYLuPhW+.EhLcaDTh.s..cG......c......s......S.....pVtc.llsGph..........hs....p.t.....hs..GhAuVuNlGsDtsW......................	0	42	84	108
+7317	PF07489	Tir_receptor_C		Translocated intimin receptor (Tir) C-terminus	Moxon SJ	anon	PRINTS	Domain	Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation [1]. This family represents the Tir C-terminal domain  which has been reported to bind uninfected host cells and beta-1 integrins although the role of intimin binding to integrins is unclear. This intimin C-terminal domain has also been shown to be sufficient for Tir recognition [2].	20.50	20.50	21.00	97.30	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.38	0.70	-4.59	6	133	2009-01-15 18:05:59	2003-11-11 10:58:32	6	2	104	5	1	76	1	210.30	70	40.11	CHANGED	lESNAQAQpRYD-QpAKRQpELslSSGsGYGLSGALILGGGIGAGVTAALHRRNQPsEQpTTTTTpTs......................lpNpsusNTsAQG...NsDToGsE-.outoRRsSpuSsAS.phSDTSSs-TV.NPYA-VshopNssph..ctsEEsIYDEVAAD.PsYSsIQ+huGssPso.uRLlGsPGpGIQSTYALLA.SGGLRhGMGGLTGGupSAsSosNssPsPGstRFV	.IEsNAQAQpKYDEQpAKRQEELplSSGsGYGLSGALILGGGIGsuVTAALHRKNQPsEQ.TTTTTp.Ts.......................V-NpPuNNTPAQG...NsDTsGuE-.o.tSRRsS.ASsuS.saSDTSShGTVpNPYADVttuhpDS.s..ppSppsl.s.sssD..ssYSsIQH.stsosss.uRLlGsPutGIQSTYAhLA..SGGLRhsMGGLTGGup.SAVsTuN..ssPsPGstRFV.............	0	0	0	1
+7318	PF07490	Tir_receptor_N		Translocated intimin receptor (Tir) N-terminus	Griffiths-Jones SR, Moxon SJ	anon	PRINTS	Family	Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation [1]. This family represents the Tir N-terminal domain  which is involved in Tir stability and Tir secretion [2].	25.00	25.00	31.00	31.00	21.70	19.80	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.66	0.70	-4.77	4	135	2009-01-15 18:05:59	2003-11-11 11:08:53	6	3	104	0	1	78	0	256.50	76	48.76	CHANGED	MPIGNLGHNsNVss.IPPAPPLPSQTDG.AtGupGQLIsSoGsLGSRhLFTPlRNSVADusDuRuSDlPGLPsNPhRlAA..SEloLpsGFEVLHD+GsLDTLNptIGSSsFRVETQ-DGoHlAIGQKNGlETSVlLS-QEauSLQuIDPEGKs+FVFTGGRGGAGHuMVTVASDIsEARQRIl-KLEPKsot..........................csopSGusNSuEsp...ssopopTSTSTSSLRSDPKLWLSLGoIAAGLIGhAATGIAQAlALTPEPDDPTTTD	.MPIGNLGHNPNVNs.IPPAPPLPSQTDG.A.GGRGQLINSTGPLGSRhLFTPlRNShADSuD.sRASDlPGLPsNPhRLAA..SEloLpsGFEVLHD+GPLDTLNpQIGSSlFRVETQ-DGpHlAlGQ+NGlETSVVLS-QEaupLQSIDPEGKsKFVFTGGRGGAGHAMVTVASDIsEARQRIL-hLEPKsTGtppsts....................c-opSGu.sosps.....hoETpTSTSTSSLRSDPKLWLuLGTlAsGLIGLAATGIsQALALTPEPDsPTTTD....	0	0	0	1
+7319	PF07491	PPI_Ypi1		Protein phosphatase inhibitor  	Wood V, Studholme DJ	anon	Pfam-B_11090 (release 10.0)	Family	These proteins include Ypi1,  (Swiss:P43587), a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor [1] and ppp1r11/hcgv (Swiss:O60927), annotated as having protein phosphatase inhibitor activity [2-3].	19.50	19.50	19.60	25.50	18.50	18.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.15	0.72	-4.34	38	331	2009-01-15 18:05:59	2003-11-11 14:35:32	6	8	258	0	231	305	1	66.50	40	41.30	CHANGED	lL+LRssp............................ppc++VpWsEsVVDNEphsKKKSKlCCIaHts.+sasE...........SSo-......ssuss.-	...............................................pLp......................................psc++VpWspssVD.NEths+KpSK.....s.........C...CI.Y+Ks.+sas..E....................SS.o.-s.ss-p.pp................................	0	78	125	191
+7320	PF07492	Trehalase_Ca-bi		Neutral trehalase Ca2+ binding domain	Finn RD, Bateman A, Wood V, Studholme DJ, Moxon SJ	anon	Prosite	Domain	Neutral trehalases mobilise trehalose accumulated by fungal cells as a protective and storage carbohydrate. This family represents a calcium-binding domain similar to EF hand. Residues 97 and 108 in Swiss:O42893 have been implicated in this interaction. It is thought that this domain may provide a general mechanism for regulating neutral trehalase activity in yeasts and filamentous fungi [1].	25.00	25.00	25.90	25.00	24.30	16.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.36	0.72	-4.62	19	181	2010-01-08 16:37:03	2003-11-11 16:42:46	6	3	147	0	122	182	1	30.00	62	4.12	CHANGED	LcpLLppEDTDpNhQITIEDpGPKVlsLGT	..LcpLLppEDTDpNhQITIEDsGPKVlslGT....	0	37	70	105
+7322	PF07494	Reg_prop		Two component regulator propeller	Yeats C	anon	Yeats C	Repeat	A large group of two component regulator proteins appear to have the same N-terminal structure of  14 tandem repeats. These repeats show homology to Pfam:PF01011 and Pfam:PF00400 indicating that they are likely to form a beta-propeller. This family has been built with artificially high cut-offs in order to avoid overlaps with other beta-propeller  families. The fourteen repeats are likely to form two propellers; it is not clear if these structures are likely to recruit other proteins or interact with DNA.	20.40	15.10	20.40	15.10	20.30	15.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-7.26	0.75	-7.61	0.75	-3.21	668	7311	2012-10-05 17:30:42	2003-11-17 13:40:01	6	214	468	96	1696	7326	915	23.90	33	6.00	CHANGED	slsss.tlh..slhp...DppG.plWluops	..............Lsss.plp...slhp...DppG.plWlGTt.....	1	834	1511	1628
+7323	PF07495	Y_Y_Y		Y_Y_Y domain	Yeats C, Bateman A	anon	Yeats C	Domain	This domain is mostly found at the end of the beta propellers (Pfam:PF07494) in a family of two component regulators. However they are also found tandemly repeated in Swiss:Q891H4 without other signal conduction domains being present. It's named after the conserved tyrosines found in the alignment. The exact function is not known.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.15	0.72	-4.22	79	2976	2012-10-03 16:25:20	2003-11-17 14:52:01	8	220	527	18	642	2956	292	64.40	23	6.25	CHANGED	shssspphpYpYhlpuh-.spWhphss.s...........phsassLssGpYplplpspsptsphs.s..tplslplt	..........................tspphpYpYpLcG..h..-..pp....Whp.h.sstp..............phsaosL..ssG.pYphpV+.up.sps.u.thstp....tplphhl...................	0	299	555	608
+7324	PF07496	zf-CW		CW-type Zinc Finger	Yeats C	anon	[1]	Domain	This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by [1], and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including ...chromatin methylation status and early embryonic development." Weak homology to Pfam:PF00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found [1].	23.20	23.20	23.50	23.60	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.38	0.72	-4.26	52	682	2009-01-15 18:05:59	2003-11-20 14:53:00	10	54	121	3	435	667	21	48.90	35	6.09	CHANGED	thWVQC-..pChKWRpLP..tphs...pplsc..tWhCphNs.....ssth...ssCsssE-ht	........hWVQC-..pCh.KWRpLP....tphs......pphsc..pWhCshNs.....ssph......spCss.PE-...................	0	120	218	310
+7325	PF07497	Rho_RNA_bind		Rho termination factor, RNA-binding domain	Finn, RD	anon	Pfam-B_1610 (release 11.0)	Domain	The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers [1].	21.00	21.00	21.10	21.40	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.42	0.72	-4.34	16	3771	2012-10-03 20:18:03	2003-11-21 13:57:14	7	13	3677	47	859	2307	2356	77.10	55	16.60	CHANGED	lau-GlLE.lLsDGFGFLRSs-ssYLsGsDDIYVSPSQIRRFsLRTGDolpGpIRsPKEuERYFALl+V-slNh-sPEp	..................hscGlLE..IL...........D.....G.aGFLRosp.sYLsGs.-DIYVSsSQI.RRFsLRTGDslsGplR.........s.......P..............K.-........G.............E..............R............Y...........FALL+Vsp..VNhcsPE...............................	0	304	582	738
+7326	PF07498	Rho_N		Rho termination factor, N-terminal domain	Finn, RD	anon	Pfam-B_1610 (release 11.0)	Family	The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers [1]. This domain is found to the N-terminus of the RNA binding domain (Pfam:PF07497).	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.76	0.72	-4.19	139	3972	2012-10-03 03:04:30	2003-11-21 14:02:28	7	30	3568	44	1023	2585	1952	41.90	35	9.71	CHANGED	-L.cphsls-LhplAc.clsl.c....shuphRKp-LIFsILcspucpss	........pL.cshslsELhplAc.ph.sl.c.....s.huc.....h+.Kp-LlaAIl+tpscps............	0	349	705	889
+7327	PF07499	RuvA_C		RuvA, C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_1373 (release 11.0)	Domain	Homologous recombination is a crucial process  in all living organisms.  In bacteria, this process the RuvA, RuvB, and RuvC proteins are involved. More specifically the proteins process the Holliday junction DNA. RuvA is comprised of three distinct domains. The domain represents the C-terminal domain and plays a significant role in the ATP-dependent branch migration of the hetero-duplex  through direct contact with RuvB [1]. Within the Holliday junction, the C-terminal domain  makes no interaction with DNA [1].	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.28	0.72	-3.79	100	4234	2012-10-01 23:03:33	2003-11-21 15:47:17	8	7	4202	23	886	2640	702	46.70	32	23.40	CHANGED	shhs-ulpALhuLGYppp-Apcslppl.....ssshs....s-p.hI+tAL+hlt	...............pEAlpALluLGYptpEup+....slpplt........tssto.............s-p..hI+pAL+th.h...............	0	290	583	752
+7328	PF07500	TFIIS_M		Transcription factor S-II (TFIIS), central domain	Finn RD	anon	Pfam-B_1373 (release 11.0)	Domain	Transcription elongation by RNA polymerase II is regulated by  the general elongation factor TFIIS. This factor stimulates  RNA polymerase II to transcribe through regions of DNA that  promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III.  The two C-terminal  domains (II and III), this domain and Pfam:PF01096  are required for transcription activity [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.45	0.71	-4.02	84	1033	2009-01-15 18:05:59	2003-11-21 17:01:31	9	29	337	6	638	962	110	113.30	28	17.99	CHANGED	pscplRspsh.chLhsuLttt..tpp.................ssppstplAtplEp.............................tlaphh....ts...ss...pcY+p+hRSlhhNLKc.+NssL+p+llsGplospp...........LspMospEhAS-ch+ptc.cphpccslppsph	.............................................................................................................pthRppsh.chLhtsLhtt.......pt...t...........................................tppstp.lAtpIEp.......................................................................................................t.lap.h................ps....ss..................tcY+s+hRSlhhNL.KD.+Ns..sL+cpVL...sGp..loPpp...........ls.pMos.-EhAScEl..pphc.cphpccslpph..............................	0	179	295	458
+7329	PF07501	G5		G5 domain	Bateman A	anon	Bateman A	Domain	This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies.  It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA.  The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.	20.90	20.90	20.90	20.90	20.10	20.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.40	0.72	-4.03	140	4313	2009-01-15 18:05:59	2003-11-21 17:13:06	7	239	1219	7	576	3447	28	77.50	25	10.80	CHANGED	clpppppsppcp..lsapsppppDssL.pGp.pcVhppGpsGh+phshplshp..sGpcls+p.llspplhp.tPhscllthGTcp	......................................h....p.psp.pcp..ls.F.ps.pppcsssL....t......G......p...pp......V....hp.......p.......GpsGp..+p..h..h..hplhh.....sG..p...c..........s....p.....cp.h.......l..sp.p.l....sp...ts.hsclVclGTc....................................	0	260	400	487
+7330	PF07502	MANEC	MANSC; 	MANEC domain	Mitter R, Fitzgerald S, Guo J, Studholme DJ	anon	Guo J	Domain	This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins [1].  Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors [1].	23.90	23.90	24.20	25.00	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.67	0.72	-3.99	14	245	2009-01-15 18:05:59	2003-11-25 16:33:57	9	11	78	0	128	211	0	89.60	31	20.16	CHANGED	ssspsChsp.....Fps.htshlIcoptSlstGApFLcus.pVtohc-ClpACCossp......CslAlh-tptsss.ss......CaLFsCh..sp.sCpFssppGasoY	..................s..t.C.tt..........h.shllcsptSlp...t.GApaLps...plpstccClpuCCppps......CNlAlh-tptsts.tss..............CaLhpCh....p...p.sCpFssppGahsY.....................	0	24	32	69
+7331	PF07503	zf-HYPF		HypF finger	Yeats C	anon	Yeats C	Domain	The HypF family of proteins are involved in the maturation and  regulation of hydrogenase ([1]). In the N-terminus they appear to have two Zinc finger domains, as modelled by this family.	23.00	23.00	23.10	23.10	21.80	22.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.76	0.72	-4.53	185	2924	2009-01-15 18:05:59	2003-12-02 16:07:56	7	13	1412	12	778	2421	117	34.90	45	9.25	CHANGED	hCspCtc.Eap-Pt..s.RRa+tphhuCspCGP+hslhp	...hCssChp.EhpDPt..c.RRa+h..lsCscCGP+hpll.......	0	258	529	666
+7332	PF07504	FTP		Fungalysin/Thermolysin Propeptide Motif	Bateman A, Yeats C, Rawlings N	anon	Yeats C	Motif	This motif is found in both the bacterial M4 peptidase propeptide and the fungal M36 propeptide. Its exact function is not clear, but it is likely to either  inhibit the peptidase, so as to prevent its premature activation, or has a chaperone activity. Both of these roles have been ascribed to the M4 and M36 propeptides ([1], [2]).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.11	0.72	-4.49	142	1811	2009-01-15 18:05:59	2003-12-03 12:00:01	8	74	862	2	304	1431	39	50.00	25	8.45	CHANGED	shph..hcspps.spGt.s+sRapQpapGls.VhGspls.lphspsGplpshsGshh	................tapl.hptpps.tpGh.s+l+hppshpGls.Vhuspls.l+.....hs.csGplhtlsGsh.t.....................	1	102	178	249
+7333	PF07505	Gp37_Gp68		Phage protein Gp37/Gp68	Studholme D	anon	Manual	Family	Homologues of phage proteins Gp37 and Gp68 are found in several bacteria.	24.10	24.10	24.40	25.40	23.10	24.00	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.95	0.70	-5.22	10	525	2009-01-15 18:05:59	2003-12-03 20:35:13	6	5	427	0	163	511	57	235.60	33	93.07	CHANGED	scTsIEWTDATWNPlsGCTKl...SPGCsNCYApphAcRhcuhuscpYp.suscppt.hu.hpt.lplctcpLphPtsWc+PRRlFVNSMSDLFHsc..VP--aIpcVFsVMcpsPpHsaQlLTKRssRhtclhsphth..............................sNVWLGsSlEsps.u.hRI-cLRcVPAulRF....lShEPLLGsls.......................................sssLssIHWlIVGGESGssARP.McP-WVRcIR-pCpsuGlPFFFKQWG......................................sh..t.hctuKKAsGRpL-GR...saDEhP	............................................t.................sWNPhtGCp.......+l.......SsGC.....ppCYA...ph.sp.+hth........t....t....t.at.ts..........................................h.........p....h........p..pp...................h...p......h..php.................psphlas.suh.S.......DlF..ttc......hss.pahpcla...p.hhc.....pssp.hpa.lLTKRspRhtphhsp......h................................................................sNlWhGsoVE.spp...s.hR........lsh...L.p.p..lP....A....t..h.+....a........lShEPLLssl.s....................................................................t.h.sh.ss.I.-WVlsGGE....S....Gsp...u...Rs.....h..c.....-..Wlhsl+-QCtt.s......slsFaFKQhG....................................................................................................t...t.................................................................................	0	54	118	148
+7334	PF07506	RepB	ParB; 	RepB plasmid partitioning protein	Studholme D	anon	Blast	Family	This family includes proteins with sequence similarity to the RepB partitioning protein of the large Ti (tumour-inducing) plasmids of Agrobacterium tumefaciens[1-2].	30.00	30.00	30.60	30.70	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.97	0.71	-4.42	15	449	2009-09-10 17:01:13	2003-12-03 20:37:47	6	4	222	0	133	437	33	167.50	21	53.66	CHANGED	ARssLohI-ctthhs+LhppGhscspItsALuhstspltph....cslsptlp.t..thltth.h.lsshuhsppluRsR.lElucLh.........hsh..p.hpss.hhcph.sss+hstLhphl..+sp+tcphospshu..p....tsc.hs.ths...pulpshhcppG.ptpLtlcsspuh........phs+aLscphschhspF	..............................RpcLSaIEcshas......tcLpppGa......s..c..ctIt..sALul.ctstl.sc..h........pslsptl..............ltsIGsAhplG..Rs..RWh..-..lschl....................hsh...p.h.pss....h.....p..uh.........ss..p+hptlhphl.......p.tpt..p..p.ss.p.t.hu..t.......tpp..ht..s.p....tth.hhh.pptu..p.pltltttps..............th.hp.al.tp...............................................................................	0	18	64	92
+7335	PF07507	WavE		WavE lipopolysaccharide synthesis	Studholme D	anon	Manual	Family	These proteins are encoded by putative wav gene  clusters, which are responsible for the synthesis of the core oligosaccharide (OS) region of  Vibrio cholerae lipopolysaccharide [1]. 	20.10	20.10	21.30	26.80	19.60	18.60	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.91	0.70	-5.54	9	166	2009-01-15 18:05:59	2003-12-03 20:40:37	6	2	116	0	15	97	30	294.30	36	92.33	CHANGED	IoVVlQGPV.s..sR.ppptuITppClsSlRsHLPGupIIlSTW.spsluGL-hDpllhs-DPGuslh.a..Dstsp.phN.NRQlVSThsGL+pVpTPYAlKLRuDNhLTustFlslhcpasp..RsspaphFcp+llsossahRc.p+GhsVhFHhSDhFpFGhTpDLLtlW-.sLhp-.phspss.....htp....tshsshphssEQhh...Wlpsh++hs.phcLtphp.-huhpphph.-phhusNlllssPcplGLslsp+Fhtpsphspp......apph-..............WlpLYpphC..s...ht.tsthphhhshhh.....+.+hl+hhhp+lcph	......................IThVlQGPl...........ssITppslpplRphFPtupIIl.....STWcG.......p...s..h.p.sl-......h..D.pll...cD..PGus.hhh......Y......cspsh...lNhNRQlhSThtG...L+tV.K...T....YAsKLRsDNlLssc....p....h....lElaEp.ast......Rtps.a.phL.s........pRllsSshFhhs.c..h.G.hsV.FahSDhFpFGhspDLLplWs....s.chhs.-hc..F.p.p................tY.....scp.....s..sE.Qhl...Whssh...Ls.thclcscp.Dasuhttsh..pFhtNNLlhsss-plGLD...lsc...R.h..hc...psshsh-.............ashpc...................WhhL.p.p.l............hhhhh.........t.ptlt.hh+phh.h.........................................................................................................................	1	8	10	13
+7336	PF07508	Recombinase		Recombinase	Studholme D	anon	Domain	Family	This domain is usually found associated with Pfam:PF00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.08	0.72	-3.80	73	4989	2009-01-15 18:05:59	2003-12-03 20:46:19	8	48	1838	0	981	4422	747	105.20	23	21.67	CHANGED	sccutll+p.lachh.......h..puhuhpplsphLsppsl....s.pstt..........................W...stssl.......pplLpNshY..h............................Ghhhhsppt.......................t.hhhhps...........ta.slloc-haptspphhppp	..........................................cpAtlV+tIFchh................h.....pG......h....u.....hppIuct.L.s.p..c..ul...........s...pstt..........................................W......stssl.........ppILpN...h.Y.h...............................................................Gph...h..ht+pp..........................t...........p..p..h.h.h..c.s..................tH..p..sII.s.p-happsQphht...........................................................................................	1	429	755	881
+7337	PF07509	DUF1523		Protein of unknown function (DUF1523)	Studholme D	anon	Manual	Family	\N	22.30	22.30	22.70	24.50	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.24	0.71	-5.04	20	220	2009-01-15 18:05:59	2003-12-03 20:50:56	6	1	218	0	38	192	35	165.30	42	92.02	CHANGED	M+h.lK...hsllhlhalllhuhlaYsLPpaDlsRIoGsEVKRh..sc.sslhhusPssG......ssRDVaFIpT..........hc.....sst+shVYRNEDTsWuaP.YFKFsSAsLQAcApsh..sps.sphVtIcaYGWRlshhohFPNAlSI+sVsss-s.tshPahshllaslLhhhhahshphhRpah	......................................hhh....h+...hhllhshalhlhhhlpYshPcY-lshlTGsEVKRh..scssslstssPssG.......ssRDVYF.IpT...........pc.....cst+lhVYRNEDTtWGaPaYFKFsSAslQAcAQuh......s..s..sphVpl+YYGWRIshhs.FPNslsl+slsps-s..shPlFuaIhaslLhhhhahshphlRth................	0	5	19	30
+7338	PF07510	DUF1524		Protein of unknown function (DUF1524)	Studholme D, Bateman A	anon	COGs (COG3472) & PSI2 target BIG_246	Domain	This family of uncharacterised proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.14	0.71	-4.33	240	2469	2012-10-05 18:28:12	2003-12-03 20:53:01	6	22	1617	0	608	2165	312	139.90	16	30.04	CHANGED	hspspphtpphtthshhstttt...thhhllt.php.p.h.......stt............................l-HlhPps.st.p...........................tht.t...ttppthhss.l...uNLshls.tphN....sphu...s......psa...........htKpp......ta.t.....................................pphhhsp..lt....................hppp...ash..phlppRpptLhch	......................................................................................................................h.t.t........h..hllh.....php...p.h..........pht.....ph.................................I-HlhPps.sh..pt................................................................tht.t..ttpp+pphhss..l...uN...Lhhls..tptN............uphu...s..................tsa.........................h.cpp..........ta.t............................................pshh.hsp...lt...................................ppp....a.s...t..hp...tcppthh..h................................................................................	0	200	420	542
+7339	PF07511	DUF1525		Protein of unknown function (DUF1525)	Studholme D	anon	Manual	Family	\N	21.60	21.60	21.60	21.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.52	0.71	-4.09	32	218	2012-10-03 14:45:55	2003-12-03 20:54:55	6	1	164	0	63	210	8	108.30	39	79.60	CHANGED	tAs.....hhVhT-sp+Plp.......sssss..pVhhLDtsc+lptpLuspLPucPppAtt.spph..........lpuss.pphppplspAapGlscAWphGlpKlPAVVhD....pchVVYGpsDVspAlthhpta+pp	.....................................................................t.AtshlhTDppH.Plp.......ssssspll.LDtspplcspLsstLP..u.sPppAtt.hspph..........lpSsshpphQpcL...s...pAYQulscAW.u.lGlpKlPAVVhD....ccaVVYGpsDVspAhthhtthpt.t..............	0	8	30	51
+7342	PF07514	TraI_2		Putative helicase	Studholme D	anon	Manual	Family	Some members of this family have been annotated as helicases.	23.90	23.90	24.00	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.78	0.70	-5.67	21	472	2012-10-01 20:28:14	2003-12-03 21:24:15	6	5	346	0	109	489	32	271.90	31	46.79	CHANGED	Gahss.su.pLLuo.hcpcLlpplhppsuhscpp.......Fcphahtslc+YAchVQhLPASEsHHHutsGGhLcHuLElshaul+lppualLPssusPEcputppcuWpsAshhuALlHDlGK.lsDlclphp.....cGs.pWtsatusLsp.h+h+....Yh.......+sR.thphHsshuuhlhspllspssLsWLup.hPc.lhssLlhsluG..ph-c...........ussLuElVppADptSlspsL.u.ussstuhtssspslp+pLlsAlRtLltpchcls.spssucsW...lsp-.uLaLVtKssuDplpuhLhspGls.ulPss..sssLh-hLtspGllpsss.-...scul	................................................Gh..s.ss.pLLus..ppphlpplhp.p.....s.u.hs.pp........Fpphhh.sl..c..c..hAthlQ.l..PASEsHHHutsGGhlcHuLElshaAh+lppuh.l.hss....su....sPE-pstppttWpsAshhuAL...hHDlGK.lsDlplp.t......sGp...tWtP.h.h.ss....lsp....h+h+....Yh........ptc......HtthusllhppllstpslsWLup.hPp.lhtsLlhsl....uG.....phpt.............sslLuclVhpADptSlsppL.t.tp.sht.........t...........t...sh.c.lhtuh+.ll.tp..ph...s..p..ucsa..............h.pp....tlal..h.p.hsc.lhthl.t.p.....th..........hPtp..s..hhs.h.p.thh..s..............................................................	0	14	49	84
+7343	PF07515	DUF1528		Protein of unknown function (DUF1528)	Studholme D	anon	Manual	Family	\N	21.50	21.50	22.70	21.50	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.41	0.72	-4.00	40	328	2009-01-15 18:05:59	2003-12-03 21:28:01	6	4	247	2	80	310	7	98.90	36	19.65	CHANGED	lhlN-scAhVHhVssssFLVoPulFpcYhpcp............uptp..ptpsaphlQ+pFE+LplH++p........sGhNlWpCcVhGsRKs.p....cLpGYLlpssph..hhsp.s.PssNPaLpl	..........lhlNcscAhlHhVssssaLVoPulFppYhppp............uttp..s.psaphlQ+pFEcL..plH++p........sGhNlapsplhGsc+s.p.............pLpGYLlpssph...hhsp.h..P.sNshLp...............................	0	9	37	59
+7344	PF07516	SecA_SW		SecA Wing and Scaffold domain	Finn RD, Bateman A	anon	Finn RD	Family	SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane.  SecA protein achieves this translocation, in association with SecY protein, in an ATP  dependent manner.  This family is composed of two C-terminal alpha helical subdomains: the wing and scaffold subdomains [1].	26.70	26.70	28.30	26.90	26.20	26.50	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.57	0.70	-4.57	171	5380	2009-01-15 18:05:59	2003-12-04 14:10:21	8	25	4467	32	1115	3923	3227	206.70	32	24.32	CHANGED	sIcp.....phlo+ulEpAQKKVEupNF-hRKpLL-YDDVhNcQRclIYppRpclLpu...........................c..c..lpchlh.phhccslpph.....lppah....stp..........ppas...hpsLpptlpphh.s.h..phslsph..............pths............................................tcp..lpcplhcthpptY............p...p.Kppphs..................................................t..chhcplE+hlhLpslDppWp-HLpsMDpLRpuIsLRuYuQ+DPlhEYKcEuaphFppMlpslcpcslphlh...+lpl	................................................................................................................................sIEpphlo+ulEsAQ++VEupNF-hRKplLcYDDVhNc...QRclIYppRpc.l.Lc..s..........................................................................................................................c..c..lpp.p.lt.shhccslpph.lsta.h.s.sp...........cpac..........lps.L.h.p.hlppth..s..h.....chsl.p..ph....................pth.s.......................................................................................................................................t-p....lp-tlhpps.ctY.....pp....+pp.t.ls........................................................................................................................................t..-hh.c.phE..+h..l..hLpslDstWp-HLssMDpLRpuI.tLRuYu....Q+sPl.EY+pEuaphFppMlpslcp-ssphlh+sp.h...............................................................................................................................................	0	382	745	956
+7345	PF07517	SecA_DEAD		SecA DEAD-like domain	Finn RD	anon	Manual	Domain	SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner [1,2].  This domain represents the N-terminal ATP-dependent helicase domain, which is related to the Pfam:PF00270 [3].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null --hand HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.72	0.70	-5.10	90	5907	2012-10-05 12:31:09	2003-12-04 16:33:08	9	48	4809	34	1211	5542	4671	373.00	47	44.91	CHANGED	l.pphh....tsts....c+pl++h..............pp.hlppIsshcsphpsLoDc-Lcpcopch+p+l.......ppG......................................c.......oL-p..............................lLsE...AFAllREAupR..............................................slGhctaDVQllGGlsL.........+pGpIAEMpTGEGKTLsAoLPuYLNALsG+GVHlVTVNDYLAcRDu-.hMu.lacaLGLoV..Gllhsshs..................................................s.ppR+p...............................................................uYtsD..ITYuTNsEhGF....DYLRD.Nhshstppt.....................Vp.R...shpaAIVDElDSlLIDEARTPLIISGssppssphahthsphstphppppptphppppptthhpppsttptcphhthtthhtt.........................................................................................................................................................tphphhchlppuL+AptLac+cpcYlVp-scVhIVDEaTGRlMtGRRao-GLHQAIEAKEsVpIpsEspTlAoITaQNaFRhYpK.LuGMTGT..ApTEspEFt	..............................................................................................................................................................h....h..s.ts.c+pl+c.h..............pc.hlp.pls....sh.E.sphpt.L.........oD..-p....L+s...KTtE...F+pRl..........tp.G............................................................................-........oL.D.s...................................lL.PE...AFA..l.V.R...EA..u.+R...........................................................................Vl..G..h..c..aD.VQl.h.G...G.h..lL...........................Hp.G.p..IAEM......+......TGEGKTLsA.T.hPs..Y...L.N..A.L..........s..............G.....+.......G..V.H.....VV.T.V.NDYLA.pRDu..-........Mu.la.p.F..LG..L..o.....V..G..l.......l....s..s.h.s...................................................s..tp.++..p...............................................................AY......s......s......D....ITYuTNN....................EhGF.....D.Y.LRD..NM.sh.p...h...--h.....................................V.Q...R...s.....hp.....a..AIVDE.......VD.SI..L.....IDE.ART.PL..IISGssccsophYhphsphh.pLhppcc.p.cppppthhhsppshpptpphhthtthhtt..........................................................................................................................................................tsh.lh+alstAL+Achlhp+Dh-YlVp-uEVlIVD-aTGRhMtGRRaS-GLHQAlEAKEGVpIpsEsp.Th.A.o...ITa.QNaFRh...Yc..........K....LuGMTGT..AcTEttEF......................................................................................................................................................................................................................................................	0	452	817	1053
+7347	PF07519	Tannase		Tannase and feruloyl esterase	Studholme D	anon	Manual	Family	This family includes fungal tannase [1] and feruloyl esterase [2-3]. It also includes several bacterial homologues of unknown function.	20.00	20.00	20.10	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	474	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.63	0.70	-5.78	8	801	2012-10-03 11:45:05	2003-12-04 17:38:35	6	15	346	0	504	870	96	395.40	25	79.35	CHANGED	CcVpG.....hpsscspt.pItFplpLPs.sWNGRalQsGsGGasGslsssst.s......hs.sLspG.aATsuTDuGHcAsss......sssFu.hss-shhsFAYpAl+cssssuKtLlpsaYs+sscp...sYFhGsSsGGREGLhAAQRaP--YDGIlAuuPuhsa.lptp...hatuh.u+sshss.....sshlsssclpllspAslspCDslDGssDGlVsDPctC+hshs......psLhCpush.........ssc....................sCLTssQlpslsplas.Ghp.....usGpshYsGas..s.....hGs.ssshspWhhss...............ts.hsstssphhp.hl..............hpssNaDsso.hch...tthccp....htplsssIsATsPDLosFRs+GGKLIhapGhsDPsloPtuolpYa-uVhA+hsts............pscsFhRhahlPGhsHsGuGsusssh...............DhLsshssWVEsGpAPspllAsctssss.........................hsRoR.LCpYPphshacGpGsscsAsSapCs	.................................................................hts....tt..t....tlthph..hL.Pt...s............Ws...s...R...hh.h...Gs.GGh.s...u...sh...s.s...................................hs.s.lt..G..aAshuoDsGa......s...us............................h....u......hs..p......t......h.h......sa.u.apulpths.huK.tlhpthY..u..p.s......s.p.h...................oYa.GCSsGGR..puhh...tsp+aPppaDGllAusPu...hp...h..sp.............hhth..h............h....ht.................s.h.ss.s.p.h.p.h.ltp.ts.lttCD.s.l..DG..h..tD.......Gllps..st...hCp.hp.p............shhC.tss..............ts..............................s.s.lostph.....tshp....p.las....s.hs.........ssGph....ha...sh..............s..................s...........h.t............................................s..th.ht.....hh..........................................s.s.h..s..t.hs...............t.....t...tt.h......h.hs..s...sp...sD.L.osap..p..p....G...GKllhaHG................h.......u.....D.hlsstsohtaappltpt.h..t.t.............................thp..pFhRhahlPGhsHCs....s...u..s..s..ss...h............................................s.hltslhpWVE..p.G..huP.pt.l..usths....sst...........................................thpR.lC.aPhhsh.at......u..G..s...pts...tsa................................................................	0	92	240	394
+7348	PF07520	SrfB		Virulence factor SrfB	Studholme D	anon	Manual	Family	This family includes homologues of  SsrAB is a two-component regulatory system encoded within the Salmonella pathogenicity island SPI-2.  Among the products of genes activated by SsrAB within epithelial and macrophage cells is Swiss:Q9KIJ9 [1]. Homologues are found in several other proteobacteria.	19.10	19.10	19.60	20.60	18.10	19.00	hmmbuild  -o /dev/null HMM SEED	1002	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.76	0.70	-13.73	0.70	-7.08	12	283	2009-01-15 18:05:59	2003-12-04 17:59:07	6	2	255	0	53	223	26	878.30	58	97.93	CHANGED	M.LspLscapp.ploLl.cSGIQFLDFuLp.phssc......sucFlcpsusGslhRL..ctsss+a..hlP...............spsGh.sclscs-h.olshcpSLclhpslWLPlPFhRhpPscs......FspGPsNWARlpllpL.spPDpcGNTHRlsLAFDTplhscpts.htYLAPscsDlpsGssFuLAa+sc-lu.FL-..............psWVssWL+ElFpp.s.tp.ctRstc-........lpctLtthEapAHYLNlLslLG...........splplPcl+llssshps....sIsVDLlLDVGNS+TCGlLIE-Hsp-ss.GLppshcLpLRDLSpPchlYs-.FESRlEFApApFG+pcaSlcSGRsDAFhWPoIsRVGsEAsRLAhpRpGTEGuTGlSSP+RYLWD-pshtpGWRF.....stshspoppEPLATAsPltphlN-pGcsLapL...........st--RlPVFpPpYSRSSLMTFMLuElLsQALhQINSsApRh+hspsssPRpLRslILTlPsAMPKsERcIFRpRhppAluLVWKuhGWa.tDsDh...p.tsppp....spsPlPtlphcWDEAoCGQhVYLYsEstspaGG+scpFFssh.t.....RP-p....t..s..t+sLRlASIDIGGGTTDLsIopYtLDcG.....hGsNVpIhPc.hFREGFKVAGDDILLDlIpchVLPAlptuLpptGhss..sculhucLFGs-..ut.stptlLRQQhsLQlFhPlGhulLpsYEsaDPhsspupl.phoFu-LLt..............................phP.oppVlsYlspslc+...susssFslhslPLtlcLspl+pthl...ssphslspslcuLCEllphYsCDVLLLTGRPSRLPGlQALhRphpPlPssRllPlcsY+sssWYPFpcpG..RIDsPKoTAAVGAMLChLu.s.RLssFhF+sschtsYSTlRYlGhLDsN.NtlpDpslaY+DI...........DLDsPshpLs.ctpFphRGphpLGFRQLss-RWsAoPLYpLsls..ssclA+plsG.......cusLpVcLp.......ptus........pcsshEpFtIs-A.h.psGspls...........pplpLpLsThssptusss.YWlDoGSlhhc	........................MLssLsDYKQ..plTLItNSGlQFLDFuLoPp.tss...c.......u+F.............VR..K...oA..N...GP.....LLR..Ls..ac...psG+Y..sLs.....................................stsGutPEl..VKPE..o.sLc.SLclLsslWLPLPFL.RFsPPRT......FlpGPDNWARlQlhpL...spPD.psGNTHRlTLAFDoplhtph.....s...hLAPsENDlhsGspFALAa+s-Elu-FLD..............pTWlDGWLREsFhphA..uphEpRstpt...........IppuLRpFE.YQAHaLNLLsLLG...........pQLslPElKhsopTLpp...PAlsVDLILDVGNoHTCGlLlEDHuDtss...GL+Q....T.hELQlRsLScPpaL....s.LFpSRVEFupA+FGKQpFSVESGR-D.AFlWPSIsRVGcEAptLAhQ.....Rl..G..T....EGSoGI.....SSPRRYLWDEpshhtsWRF.....sphts.p...sp.....cEPLATAhPLhpLhND-GpPLapL............Ph-ERLPVFSPpYSRSoLMTaMLsElLAQALhQINSsApRL+h...sassuPRQLRolILTLPSAMPK.EREIFRpRMhEAlALV..WKuMG...........WHPtD-..DFs.........ospp+tK........ShVPVP.-lQMEW..DEAoCGQlVaLYNEs.spauGRo-u.FFsuh.A.....RPD+p.p..su.ss..G+sLRlASIDIGGGTTDhAIspYpLDD....G............sGsNVKIoP+LLFREG.FKVAGDDlLLDlIQphVL......Pu.......LQsuLp+AGVss..usuLhupLFGss..GRhDsQulLRQQssL...........QlFMPlG+AlLpAaEp.D..DshAt.....l.cAoFG-LLh..............................ppP.TppVhsYIppsIp+.tLPuu.ussFDIhsVPLplphSpLppthL...uspholTpsL+AlCEslShYpCDlLLlTGRPopLPGlQALhRHLQPlPsNRIl.hDtYpsp-....WYPFsppG..RIsNPKSTAAVGAMLC.LALD.L.RLspF.FKAuDh..t..sYSTlRYLGhLDso..ssLp-ENlaY+-I...............DLDpsshs...L..s..sch+F....lRGs.loLGFRQLsNsRWPAoPLYsLSIs...ssELA+plAG...................Du.V..Ls..V+L+................lpsus..................+csuPE..pFhLu-AhL..pDGos.Vsh..........ctLpLKLNTLAsptpu.uoHYWIDSGSVah.c...........................................................................	0	4	17	37
+7349	PF07521	RMMBL		RNA-metabolising metallo-beta-lactamase	Finn RD	anon	Pfam-B_760 (release 11.0)	Motif	The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases.  The fifth motif appears to be specific to function.\	    This entry represents the fifth motif from metallo-beta-lactamases involved in RNA metabolism [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.99	0.72	-4.14	138	6209	2012-10-01 19:09:44	2003-12-05 14:54:50	7	36	3653	52	1894	4689	1569	40.50	33	7.13	CHANGED	chhtlchplpplc.hSuHAcpp-Lhphlpth.ps...cplhlVHGE.p	...........t.........ppl+..sSGHuspp-lphhlsh...l..+P.........+hhhPVHGEh....................	0	666	1222	1605
+7350	PF07522	DRMBL		DNA repair metallo-beta-lactamase	Finn RD	anon	Mannual	Domain	The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases.  The fifth motif appears to be specific to function.\	    This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair [1].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.69	0.72	-4.02	43	592	2012-10-01 19:09:44	2003-12-05 17:30:10	9	30	300	0	406	592	9	106.50	25	15.45	CHANGED	spltshlTs-.tpsplHll.shs......plp....hpsLtsahpthttp......asplluh+PTG..Wshps.htt..s..t.............................................ttphslaslPYSEHSSapELccFVphl+Pp..clIPTVssss	....................................................................thhTss......t..tsplHhh..h..........php.........hppl..phhpt....t...h................hpph..luhpPou......Wshptt.h..t.p...................................................................................ttt.tha..tlPYS-HSSapELppF..lphl+Pp..pllP.sVs...s.........................................	0	126	211	313
+7351	PF07523	Big_3		Bacterial Ig-like domain (group 3)	Bateman A	anon	Bateman A	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.09	0.72	-3.90	40	2232	2012-10-03 16:25:20	2004-01-06 12:05:57	7	198	845	2	141	1725	26	68.80	28	14.33	CHANGED	lps+DSTIYlGDsWsuc.DNFsSAssKsGps........lsas-lpVsG.......sVDospsGsYplTYoasG......sopolsVTV	...........................h..spcsshhhG...-s..a.ssp..ssh.lsApsc.s.Gss.............ls.hsc..lp.VsG...................plDos..K....s...G.p.Y.pl.oYp.aps.............hptshpVpV........................	0	69	91	112
+7352	PF07524	Bromo_TP		Bromodomain associated	Studholme DJ	anon	[1]	Domain	This domain is predicted to bind DNA [1] and is often found associated with Pfam:PF00439 and in transcription factors. It has a histone-like fold.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.42	0.72	-4.25	12	679	2012-10-10 12:36:46	2004-01-06 13:32:37	8	18	266	0	482	767	3	74.20	24	13.90	CHANGED	pchspslhp.hsluplhppsGa-ssppusLEoLothhtpYlpclucphppau.ptssRspss.htDlh.hsLtchul.sVsp	......................................tcplLphuVup.lh.pp...sGF..-ssp.uu.l-sLT-l.hpc..Y....lpplucssppas..-...t......ts..R..s....t.s......s....htDlh...sh.tph.uh.....t.....................................	0	133	242	379
+7353	PF07525	SOCS_box	Clip; SOCS_Clip; 	SOCS box	Studholme DJ	anon	[1]	Domain	The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.11	0.72	-4.09	141	2186	2009-01-15 18:05:59	2004-01-06 13:59:50	11	135	116	6	1208	1938	0	39.00	35	9.64	CHANGED	stoLpcLCRhsIRpp.lsppt........lppLPLPptLcsYLt.ap	..........shoLpcLCRhsIRpt.lstpt...............lspLP.LPspL+pYLp.a..........	0	198	297	634
+7354	PF07526	POX		Associated with HOX	Studholme DJ	anon	[1]	Domain	The function of this domain is unknown [1]. It is often found in plant proteins associated with Pfam:PF00046.	21.60	21.60	21.80	23.30	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.81	0.71	-3.95	39	330	2009-01-15 18:05:59	2004-01-06 14:12:16	6	5	36	0	166	329	0	129.90	38	22.83	CHANGED	phltsS+YL+sAQcLL-Ehss.Vup.....................ht.tptptsttptpssstssssss..sstsssssspt.ssplo...........ss-ptEhQhKKsKLluML-E..................V-+RY+pYpcQMQhVluSFEsVAGhGuApsYTuLAL+shSRHFRCL+....DAIsu	..............................t.hlhsS+aLpsAQcLL-Ehss.Vst.............................................t...tttt..t..st....t..s...sts.s..s.s.tss....ssps.ttss.s..p.s.ssplu.......................................sspttEhQh.KKsKLluML-E.....................................................................V-.+RY+pYhcQMQhVsuSF-s.......V...A......Gh..GuA.tsYTuLAL+shS+HFRCL+DuIs.s...........	0	16	100	135
+7355	PF07527	Hairy_orange		Hairy Orange	Studholme DJ	anon	[1]	Domain	The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split [1,2].  The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute[2].	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.99	0.72	-4.21	79	952	2009-01-15 18:05:59	2004-01-06 14:24:01	8	6	111	2	510	910	1	42.90	31	15.11	CHANGED	spa+uGapcChpEVs+aL.sshpuh........cs...thpp+LlsHLtpshsth	.......tapsGapcChpEVs+aL.ushcuh...................ss.......slps+LlsHLpphhs..h.................	0	101	143	313
+7356	PF07528	DZF		DZF domain	Studholme DJ	anon	[1]	Domain	The function of this domain is unknown [1]. It is often found associated with Pfam:PF00098 or Pfam:PF00035. This domain has been predicted to belong to the nucleotidyltransferase superfamily [2].	20.40	20.40	21.10	21.00	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.52	0.70	-4.96	4	544	2012-10-02 22:47:23	2004-01-06 15:10:16	9	21	114	0	254	492	0	210.30	43	35.06	CHANGED	pVGSFtKGThhpGsssuDlVllLKoLPTp-sl-tLu+KVttsLctuhcs.........Eshph........hEhGhcIosshs+VRhLIshlPpshpKLEP.hHLDpKhh.upLAulRHs+WFpppApc.......ohplLIRlLKDLspRassFpPLssWhl-LLAahuIhNsPuRQshslshAFRRVFplLAuGlFlPsSuGIhDPsE.uphRltsshTL.QpDssChoAQTLlRlhAaG..GY++ILGhcsssos	.....................................................................................RVG.lAKGLll.+.G-.sl-LVl.lspp.hPTt....sLLpplup...pLs.pLtt.hs.c..........................t.....-sh.........hh................t................hph..s......hp..lo.....Ss...h.h..+....c...........h....t.............s......s..p..s....h.t....h..D...P...........p.h.............LDpphCh.sA.L.Aul...RH..A+WFp.s...+Asslp.....Ss.hllIRlLRDLspRh.Ps.Wts...LpsW.slEL.Lsc.......+uls.....os...ppP...hu.su...cA.h.......RRlhEsluoGllL..........s....s....usGlhDPCE........cps..........hcshshhohpQp...............-slT.oAQ...p.hLRlhAFt..ph+KlL.Gh-s.s......................................	0	60	80	160
+7357	PF07529	HSA		HSA	Studholme DJ	anon	[1]	Domain	This domain is predicted to bind DNA [1] and is often found associated with helicases.	20.80	20.80	21.00	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.26	0.72	-4.19	50	836	2009-01-15 18:05:59	2004-01-06 15:46:46	8	46	264	0	522	792	6	70.80	25	4.41	CHANGED	p+htctp...+p+s+actlLpphthhupDFppt++h+.....hstsp+luchltpaapptpppcp+ctc.......tcpchptltp	...........................+htp.p...+p+p+as.h..Lpphh.hupDFppt++.p.......tupspKls+tltpaHtppccc.pc+ppc.........pcp+h+tlh.....................................	0	155	262	412
+7358	PF07530	PRE_C2HC		Associated with zinc fingers	Studholme DJ	anon	[1]	Domain	This function of this domain is unknown [1] and is often found associated with Pfam:PF00096.	22.10	22.10	22.80	22.50	21.40	21.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-8.95	0.72	-4.07	10	61	2009-01-15 18:05:59	2004-01-06 16:12:08	6	8	16	0	30	76	1	64.50	22	11.32	CHANGED	sppIcppLpcpGapsppl+shpps................ss+sPhNMFhVpLssss-..pcc....ILplKpLGph+.VsVERtp++c-s	................................................IhppLpp.Gassh..plhshppt.................pcps....h.shahlcltss.s..pcc.....lhpl+plst.h.VplEt.phpt.............................	0	13	16	28
+7359	PF07531	TAFH		NHR1 homology to TAF	Studholme DJ	anon	[1]	Family	This corresponds to the region NHR1 that is  conserved between the product of the nervy gene in Drosophila and the human mtg8b protein [1], which is hypothesised to be a transcription factor.  	21.30	21.30	21.50	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.15	0.72	-4.35	14	474	2009-01-15 18:05:59	2004-01-06 16:26:22	9	11	109	4	227	399	0	92.60	49	15.33	CHANGED	hcslpKC+pFLssLlcLuss...pus-huppVRsLVpsLlsuplpsEEFsp+L.ptLNusPQPaLVPFLKpoLPsLRphh.sspthlpQsth.hh..ssss	.....scplpKhKpF.LoTL.phusc.....SPElucpVRsLVhsLlsuslph.EE...Fps+LpcthN.s..p..............Pall.PFLK............t.s.........LPhLpptLh.csAphhpQsstQh.s...p..........................	1	38	55	123
+7360	PF07532	Big_4		Bacterial Ig-like domain (group 4)	Bateman A	anon	Bateman A	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-9.12	0.72	-4.45	98	1839	2012-10-03 16:25:20	2004-01-06 16:50:15	6	189	521	0	210	1443	6	61.30	29	9.61	CHANGED	hpshshs.st.........h..Gss.........................pLPppVpshh.s-Gos...p.......p...hsVp.W...........s........stphspsGs.aplpGp..lp..Gh	.................................................h.t.hplh..st........................l..ups....P...........................pLPppVssha...scGpp...p........p...hsVs.W...........s........thsspphspsGs.apVpGp.lp.G.............................	0	96	157	179
+7361	PF07533	BRK	TCH; 	BRK domain	Studholme DJ	anon	[1]	Domain	The function of this domain is unknown [1]. It is often found associated with helicases and transcription factors.	20.90	20.90	20.90	21.10	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.94	0.72	-4.49	20	582	2009-01-15 18:05:59	2004-01-06 17:04:04	11	35	89	5	303	552	2	46.10	40	2.68	CHANGED	slss-pRVsVlspcsG+pLsGscAPpt+cLppWLptsPsatls.....Pct	.....p.su-p.V.VlppcsG+h.LsGs-APptppLp.pWLctsPsYtVs.....Pc.............	0	54	76	170
+7362	PF07534	TLD		TLD	Studholme DJ, Eberhardt R	anon	[1]	Domain	This domain is predicted to be an enzyme [1] and is often found associated with Pfam:PF01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-11.13	0.71	-4.19	112	1684	2009-01-15 18:05:59	2004-01-06 17:16:33	11	56	317	1	1140	1627	32	133.50	22	28.56	CHANGED	ll.assp.pcGtuhps..hhpphp.......pp.ushllll.............ps.sc...h.....lFGuasspta......p.t.......ahGs...spo.FlFpl..........psphtsa+h.....ssps.........thahhssp......p.........luh.Gss..................phuLhl-s.shpp.uhs..p.hs.............soas..ss..hs..........tpppFplpslElWuht	.................................................................................lasst.pcGhS.....hps...hhppht.............hp.sssllll........................................cs.pps....t.............lF...Guass.psh..................................p.spp.......ahGs......scsF.l.Fph................................ps.p.h...p.haph............ssts.......................................t.hh.hhss..............pt.................................lshGus...............................................thuLhlcs......sh.p...uhs.p...s...............toat...s...Ls........................................ttpF.l.tlElath........................................................................................	0	519	685	941
+7363	PF07535	zf-DBF		DBF zinc finger	Studholme DJ	anon	[1]	Domain	This domain is predicted to bind metal ions [1] and is often found associated with Pfam:PF00533 and Pfam:PF02178. It was first identified in the Drosophila chiffon gene product [2], and is associated with initiation of DNA replication.	24.80	24.80	24.80	25.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.50	0.72	-4.28	29	271	2009-09-11 05:51:30	2004-01-06 17:34:58	7	7	203	0	185	277	0	47.60	39	6.36	CHANGED	pcpcsGYCENC+hKY-sh-p.................HltSc+HRpFApscpNatslDsLItpLpp	.......cp+sGYCEsCppKa-..-.h-p.................Hl..hSccHRpFAtpspNattlDplltpL............................	0	50	87	141
+7364	PF07536	HWE_HK		HWE histidine kinase	Studholme DJ	anon	[1]	Domain	Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria.  The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as Pfam:PF00512 [1].  The family was defined by [1] the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to Pfam:PF02518. These proteins are found in a variety of alpha- and gamma-proteobacteria, with significant enrichment in the rhizobia.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.64	0.72	-3.55	44	1003	2012-10-11 19:05:54	2004-01-07 14:13:07	9	153	270	0	408	2339	212	82.20	32	14.48	CHANGED	ELsHRVKNhLAslQSlspQTh+pssshschhpphpuRLtALupuHsl....LocspWtuusLp-LlptpLpPats......sp+lplsGPs	..ELsHRlKNhLAlVpuls...p..p....T..h....+..p.....s...s.....s....h....c...p....h..t..p..t...h....p...u...R..lpAL.....upu.a.s.l........L.s.c.....s...s.....W.....p.....u.....s.....s.....l....p....p....Llps....plt.sass...t......ssRl.plpGP..............................................	0	81	201	261
+7365	PF07537	CamS		CamS sex pheromone cAM373 precursor	Studholme D, Williams W	anon	Pfam-B_18913 (release 11.0)	Family	This family includes CamS (Swiss:Q8L313), from which Staphylococcus aureus sex pheromone staph-cAM373 is processed.	25.00	25.00	25.40	25.20	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.98	0.70	-5.40	7	766	2009-01-15 18:05:59	2004-01-21 15:50:20	6	2	576	4	74	428	0	278.80	36	84.01	CHANGED	PaKtupuRGlssssl..ssRhDl-EhEsGLhclup-pFss-sahaQ-GQYlDccplppalt+cp............cs......s.GLNPsh..tssshcphp.ppPhYLopILEpDYhscpDssshpLsGlsIGLAMNSV..appcpstsph...ppsIs-pchhppGcchAppllpclRpp-....shcslPIshAIY+Qts+sSlsPGNFlutssVptsssslssWpsIsEK.hlaPS.spsscpttpDssphppFppplpsaFs.N..asulVGcuhYcccphpcLplDIPlpa.GKuElluhTQalsshl.chaPK.h.clplpIpoupp.EAlIhRpss-ccPhV	.................................PactupuRGlh...s.sh...ssphsht.-aEsGLhpluKc.FsTcpYlaQ-GQaLsppTl.pt......a.Ls.K..................c..p...........s.G...LNPs.......sp.....t..s..c.....phs......sPh.YLspIlEQDahsptsspsh..pltGhsIGLAMNSV.YYp.ccp.ssp......pppls....s...pchhtp...G.+phAscllpplRppc....ph.cs.lPIphAlY+Q.usp.s.SlssGpals.uss.pps..ps.plspWcsIsEKshlhP....S....sstsp.....cp....s........sspFppFpsplpsaFs...s.a....otssupspahcpphpplslslshpaaGpsEhhuhTQalsp.s.cahsp.s.phplpIps.ss...p...pAlI.+ptssccs...........................	0	19	41	56
+7366	PF07538	ChW		Clostridial hydrophobic W	Studholme DJ	anon	[1]	Repeat	A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats [1]. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.17	0.72	-7.56	0.72	-4.43	194	1324	2009-01-15 18:05:59	2004-01-21 17:12:02	6	86	159	0	292	1109	45	35.70	41	26.52	CHANGED	HVps..hGWp.s.h.spsGphuGTsGpuhRlEAlclpLssp	..............HVQshGW.......p..s...a.sp...sGp....h......u.GTsGpuhRlEAlcIpLss.........	0	235	272	292
+7367	PF07539	DRIM		Down-regulated in metastasis	Wood V, Studholme DJ	anon	Pfam-B_10642 (release 11.0)	Family	These eukaryotic proteins include DRIM  (Down-Regulated In Metastasis) (Swiss:O75691), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells [1].  It is believed to be involved in processing of non-coding RNA [2].	24.80	24.80	25.80	26.30	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.60	0.71	-4.77	29	267	2009-01-15 18:05:59	2004-01-22 13:23:18	7	4	244	0	207	278	1	140.10	31	5.54	CHANGED	plhuKFpN.Ksla+usclaph.hhpLLsspssclQKhALcslhsa+ss.sls.Y+-NLpNLLDDspF+DElssFh..hssppps................IpspcRstlhPlllRILaG+hpspssusspp.....uR+tuVlphL.sshppp-lt.Flcluhs.l	....................lFupFtNP+slappsclaph.h.h.pLLsps-tplQ+hALcslhs..aKp..s..tl.hs.Y.c.-sLppLl-.....-..p.......pF+-ELspF..hspppt.................................lcs.pHRspLhPlllRlLYG+hhs+suupstt................tsR+tslLphL.ush..pspElthFlplhhts.............................	0	68	111	170
+7368	PF07540	NOC3p		Nucleolar complex-associated protein	Studholme D	anon	Pfam-B_8562 (release 11.0)	Family	Nucleolar complex-associated protein (Noc3p, Swiss:Q07896) is conserved in eukaryotes and has essential roles in replication and rRNA processing in Saccharomyces cerevisiae [1].	20.70	20.70	20.70	20.70	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-10.17	0.72	-3.72	30	305	2009-01-15 18:05:59	2004-01-22 13:51:56	6	4	269	0	214	288	3	96.10	38	13.28	CHANGED	lhctKEcIAclustlhEDPEENltsLccLtchspsp........phslpKLulloLlsVFKDlIPGYRIRPLoEpEtppKVSKEVp+LRsFEpuLlpsYKtY	..................................................l.ptKpcIAplustlhp..-PE..p..s..lt..........t..........L....+c.Ltphsppp....................................shslpKL...ullolhsVFKDIlPuYRIR.........s...........L.........o.E....p.E................t................p....p.....K.........lsKElp+LRpFEpuLlptY+tY......	0	74	120	178
+7369	PF07541	EIF_2_alpha		Eukaryotic translation initiation factor 2 alpha subunit	Wood V, Studholme DJ	anon	Pfam-B_5125 (release 11.0)	Family	These proteins share a region of similarity that falls towards the C terminus from Pfam:PF00575.	21.70	21.70	24.20	23.60	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.30	0.71	-4.36	78	521	2009-01-15 18:05:59	2004-01-22 14:09:57	7	4	460	17	353	497	94	115.20	34	38.02	CHANGED	-.hacpluasL.ccaG....csY-.AFc.ssspss.plLschp..ls..............................cchtcsLhphhpcplpsptV+lpu.l-lpshs.-Gl-tIK.cAL..psup..phs....scphp........lclphluuPpY..tlpspu.Dh	.........................LappluWs..Lp..c..KYG..............cua-.AF.K.slsc........s........s..l..l.csls..ls..................................c.c.h.t-sLhp.Ip++loPpslKlRADlEls.Caua.-GI-ulK.cAL.+s.up...stu.............scph.................lKlpLlusPhYllospshDh..........................................	0	119	206	294
+7370	PF07542	ATP12		ATP12 chaperone protein	Wood V, Studholme DJ	anon	Pfam-B_6737 (release 11.0)	Family	Mitochondrial F1-ATPase is an oligomeric enzyme composed of five distinct subunit polypeptides. The alpha and beta subunits make up the bulk of protein mass of F1. In Saccharomyces cerevisiae both subunits are synthesised as precursors with amino-terminal targeting signals that are removed upon translocation of the proteins to the matrix compartment [3].  These proteins include examples from eukaryotes and bacteria and may have chaperone activity, being involved in F1 ATPase complex assembly.	20.50	20.50	20.70	22.80	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.67	0.71	-4.16	100	585	2009-01-15 18:05:59	2004-01-22 14:27:18	6	9	548	7	318	554	186	126.20	35	43.45	CHANGED	KRFaKcsslt.p.........sssG.asltLDGRsl+TP.u+psLslPocs..LApulAsEW...sAQ..pctIcPtoMPlTpLussAlDtlss...p...............pstlhptlhpYhsoDhLhYRAss...........Ppp.........LspcQsctW-PlLcWspp...ph	......................KRFacpsslt..p...........................scsG..atltLDuRs.l+TP.scphLhlPocs..LAps..lAsEW.....suQ..pc.tIcstsMPlTpLsssAlDtssp...s.........................................................................pptlhcslhcahsTDhlhaRusp.........................spp...............L...hptQpcpW-PllcWhppt.h.......................................................	1	106	183	258
+7371	PF07543	PGA2	DUF1531; 	Protein trafficking PGA2	Wood V, Studholme D	anon	Pfam-B_46790 (release 11.0)	Family	A Saccharomyces cerevisiae member of this family (PGA2) is an ER protein which has been implicated in protein trafficking [2].	24.00	24.00	24.40	24.20	22.60	23.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.19	0.71	-4.38	6	125	2009-01-15 18:05:59	2004-01-22 14:39:42	7	2	105	0	89	97	0	112.90	28	84.02	CHANGED	htpNltsoFup...hohc+WIRlIllVGuYlLIRPY....FhKLusK....spt+cpEKEpAEscstp.......u+lSsNuLRGutstup....h.sE-TD-E.......Esstp.ussSusscWGKsARKRQ++hh+cL.cptEcppcc...t--DcDIpEhL-c	...............sh.tphss...hshpcalRllhIlGuYhllRsa....hh.chh.t+.....tthcphcc-p..tctctt............t..tspth+s..t..t................cp-.......cst....ttsou...tWG+psR+..+.+p........c........h.p...t.-phptp....................ppDpDIt-hLc...........................................	0	13	38	70
+7372	PF07544	Med9	CSE2; 	RNA polymerase II transcription mediator complex subunit 9	Wood V, Studholme DJ	anon	Pfam-B_45625 (release 11.0)	Family	This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator [4]. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter [5].	26.10	26.10	26.20	26.40	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.61	0.72	-4.25	43	187	2012-10-04 14:01:12	2004-01-22 16:04:03	8	1	175	0	129	174	0	82.80	25	51.36	CHANGED	ssphhPtlhshhpphtp.......sshssc-ltstsusl+h+lpcs+shlpplss....ls+oscEQppcIcpLcpplppppplLpcapppst	........................................t..phlPhlhthlpp..............hshcspDlppphssl+p+lpcsRphlpphPs....lcpoh--QppplcpLcpplppKpplLpca+phh...............	0	23	52	96
+7373	PF07545	Vg_Tdu		Vestigial/Tondu family	Bateman A	anon	[1]	Family	The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd [1].	19.40	19.40	19.70	28.80	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.35	0.72	-4.51	3	189	2009-01-15 18:05:59	2004-02-04 14:20:38	9	1	74	2	108	146	0	32.50	69	11.85	CHANGED	pYlNAuCVlFTYFpGDIuShVDEHFSRALsass	...pYlsSRCVLFTYFQGDIuSVVDEHFSRALup....................	0	15	23	56
+7374	PF07546	EMI		EMI domain	Bateman A, Doliana R	anon	[2]	Domain	The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al [2]. This is to stop the family overlapping with other domains.	21.80	21.80	21.80	21.80	21.50	19.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.38	0.72	-3.52	43	529	2009-01-15 18:05:59	2004-02-04 17:48:52	8	46	72	0	259	472	0	70.40	32	10.79	CHANGED	spNhCuhhhppslsh.....spstspshhphhhpsC....hst.tCs..............................paRsha+s....sY+hshchh..ophtacCCPGapt.s	.........................+shCuahs.s+slshh...spstspshhps..hp..C....hst.tCs..............................pYRshhRstY+hshKsl.....ophcW+CCPGapG..p....................................	0	28	49	116
+7375	PF07547	RSD-2		RSD-2 N-terminal domain	Bateman A	anon	Bateman A	Domain	This domain is found in three copies in the N-terminus of the C. elegans RSD-2 protein. RSD-2 (RNAi spreading defective) is involved in systemic RNAi [1].  Mutations in the rsd-2 gene do not effect somatic genes but only germline expressed genes [1].	25.00	25.00	25.80	25.20	19.60	21.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.77	0.72	-3.84	7	25	2009-01-15 18:05:59	2004-02-05 14:53:25	8	7	5	0	22	24	0	86.50	29	13.64	CHANGED	FSssspHhTYsRpluaADhYGhV-sup..ts.ptsssaps.Isls.lsYppstpsLFKssph.hch.ssc-ss-hhpphhpFE-ph	................FSSsspHhTYs+pluauDtYGhV-ls....c...tshcpssVYpspIslss.h..............phcsstpslFKlssh..hc.ptp...s-sspc.ahpphhpaE-p.....................	0	5	6	22
+7376	PF07548	ChlamPMP_M		Chlamydia polymorphic membrane protein middle domain	Yeats C	anon	Yeats C	Family	This family contains several Chlamydia polymorphic membrane proteins.  Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract.  This domain is found between the beta-helical repeats (Pfam:PF02415) and the C-terminal Pfam:PF03797. This domain is excised subsequent to secretion [2].	25.00	25.00	35.80	34.20	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.93	0.71	-4.49	55	594	2009-01-15 18:05:59	2004-02-19 17:21:38	6	15	39	0	64	433	0	177.10	26	16.15	CHANGED	GsLsLccsApLpstu..FoQpsGo.lhhssGosLt........................................................sssssslslssLslsLsSlh..................................................................................sspssshtssssssslo.....loGslsLl-ss.sshY-shsLspsh.phsllplssss..........sstspshssshstssss+YGYQGsWohsWpp.................ssspppslhhsWss	........GsLlLc-sApLpshs..hoQ.ss.Gu.lhhssGosLp..................................................................sssssslslssLslsLsSlh..................................................................................s.s...sssss.....h.....ssssssslo.....l.s.G.slsLlDss.sshY-sh.tLsss...plsllplssst..........pstspstphshs.ts.ss+YGYQGsWohs.Wpp..................stpspoLhhsWp..................................................................	0	9	9	50
+7377	PF07549	Sec_GG		SecD/SecF GG Motif	Yeats C	anon	Yeats C	Motif	This family consists of various prokaryotic SecD and SecF protein export membrane proteins.\	   This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2]. This alignment encompasses a -GG- motif typically found in N-terminal half of the SecD/SecF proteins .	20.30	12.00	20.30	12.10	20.20	11.90	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.36	0.73	-7.54	0.73	-4.42	145	7147	2009-01-15 18:05:59	2004-02-20 10:11:56	9	16	3512	9	1648	5001	3208	30.00	30	6.74	CHANGED	hhhhhspslshGlDhpGGspltlpsppsssh	............hhhhpshsLGLDhpGGspl.lpsc.st..h..........	0	506	1052	1384
+7378	PF07550	DUF1533		Protein of unknown function (DUF1533)	Yeats C	anon	Yeats C	Family	This family consists of several hypothetical bacterial proteins and is around 60 residues in length. It's function is not known.	20.80	20.80	20.80	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.10	0.72	-3.98	25	199	2009-09-11 11:31:05	2004-02-23 11:44:10	6	30	76	0	36	185	3	65.90	24	12.90	CHANGED	spsahpsIsclpl..NGsph.........ptscatlttsst.lplssssFscsGpppIsIKApGYpDsslph	...............................ppahppIscVpV..Nssha....................th.pspspashshss........lpl..s...sssF...p.....s.....G...c....ppIpIpu.cGa.p-hphph......	0	21	32	34
+7379	PF07551	DUF1534		Protein of unknown function (DUF1534)	Yeats C	anon	Yeats C	Family	This family is found in a group of small bacterial proteins. Its function is not known.	25.00	25.00	26.60	25.20	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.44	0.72	-4.43	3	44	2009-01-15 18:05:59	2004-02-23 11:54:40	6	6	10	0	6	46	0	39.00	56	65.19	CHANGED	LSFRTLQRGNAVuDAPRHRSAPRRAFKIGRGASRsAsshsA.spohhR	......LSFhTLQRGNAltDA.RH+SsPRRhhKhGRtAS.+suh...........t...............	0	0	0	0
+7380	PF07552	Coat_X		Spore Coat Protein X and V domain	Yeats C	anon	Yeats C	Domain	This family is found in the Bacilliales coat protein X as a tandem repeat and also in coat protein V. The proteins are found in the insoluble fraction [1].	20.00	20.00	62.40	22.20	19.70	17.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-8.88	0.72	-4.19	22	264	2009-01-15 18:05:59	2004-02-23 14:24:19	6	2	76	0	29	192	0	60.10	42	71.12	CHANGED	pscplsp-hhQhsthcQls...cpplhIcsSpsVsVoToDTpsAlslQshlQshlsl.llplsI	.......p.ssplsp-hhQpophcQls...cpplhIhsSpsVsVTTTDTchAlsIQshLQshlsl.llplsI.......	0	7	19	23
+7381	PF07553	Lipoprotein_Ltp	DUF1535; 	Host cell surface-exposed lipoprotein	Yeats C	anon	Yeats C	Domain	This is a family of lipoproteins that is involved in superinfection exclusion.  Proteins in this family have been shown to act at the stage of DNA release from the phage head into the cell [1].	20.10	20.10	20.70	20.20	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.24	0.72	-4.09	18	773	2009-01-15 18:05:59	2004-02-23 15:58:35	6	18	375	0	116	573	23	47.10	43	32.24	CHANGED	shc.psALcKAKsYucohpMS+pulY-QLsS-......aGEKFTpEpAQYAlDsL	.......c.psALppAKsYt.p.h.hp.MSKpulY-QLoS-.......hu-+Fos-pAQYAlDpL......	0	31	69	104
+7382	PF07554	FIVAR		Uncharacterised Sugar-binding Domain	Yeats C	anon	Yeats C	Domain	This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by [1]. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as Pfam:PF05089 further supports this proposal. It is found in the  C-terminal part of Swiss:O82833, which is removed during maturation  ([2]). Some of the proteins it is found in (e.g. Swiss:Q9RL69) are  involved in methicillin resistance ([3]). The name FIVAR derives from Found In Various Architectures. 	21.30	10.80	21.30	10.80	21.20	10.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.73	0.72	-3.65	225	12786	2009-09-13 16:22:53	2004-02-25 16:52:28	8	504	697	8	341	12670	23	49.90	26	19.54	CHANGED	l....spssshptttph.....hshssstpsshspAlstApsllsp.ss.....sstpplspA	........................................l.tspsssptspsY...................hsAsssppsAYssAlssAcsllsp.ss.sss.hstspVspA..................	1	168	208	297
+7383	PF07555	NAGidase	Hyaluronidase_2; 	beta-N-acetylglucosaminidase 	Moxon SJ, Bateman A	anon	Pfam-B_4394 (release 12.0)	Family	This family has previously been described as a hyaluronidase [1,2]. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity [3].	25.00	25.00	26.50	26.00	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.04	0.70	-5.51	30	535	2012-10-03 05:44:19	2004-02-26 11:24:06	8	42	380	54	170	546	259	293.30	33	30.05	CHANGED	RGsIEGFYGpPWSp--Rh-hhcFhGchKhN...TYIYAPKDDPYHRp.pWR-.YPs-El.sclp-LlcsAscs+lcFsaAluPGhsls.....ao...spcDhpsLhsKhcplhchGVRsFulLhDDIs.t.................sssupsQscLlNclpccahps+tsshs.....LlhsPTEYssstsss.......YlpsLscpLsssIplhWTGssVl.sspIohpshcph.......ssshtRsshlW.NaPVNDa..sps+LhhGPhts.pcssl..s..plsGhVoNPMppucASKlAlau....lADYsWNtpsa..DspcuWppuhchlss..............sss-slthFucp.	..............................................RGhlEGFY........Gp...PWopcpRhchhcahuchchN....oYl..YAPKDDshHRt...pWR-hYs......t-...........c..h.....pp...........lppLlpsupcsclcFlaAluPGhs.hs.........as........tpp-hpsLhpKhcQlh....p.h.GlRpFulL....hDD....Is.......................pshupsQsplhNcl.pphs....p.........c..................hlhsPT..cYssshsss.................................YLpslucpLs.s.slplhWT.GspVh.ssplo.ps.lpph...........sphh.p..RsshlW.NaPsNDa...........spp+....Lh.LGPhp......s....p.........sssl...s........plpG...llsNPMp.ph-s.....Sclulas....hAsa.Ws.tsh...ssp.pshpt.shp.h........t.t.th.............................................................................................	0	53	84	131
+7384	PF07556	DUF1538		Protein of unknown function (DUF1538)	Yeats C	anon	Yeats C	Family	This family contains several conserved glycines and phenylalanines.	20.70	20.70	22.10	22.30	19.90	20.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.31	0.70	-5.25	72	585	2009-01-15 18:05:59	2004-02-26 17:09:14	6	2	271	0	199	528	359	210.10	35	83.88	CHANGED	IllllhhFQhlll.+tshsshhpllhGhlhVllGLslFLhGlchGlhPlGcthuptlsp.....................hss....hhhllhFuFhlGFusTlAEPALhslutpsppVou..GtIs.........thslhhsVAlGVululuLGhhRIlh.GhPltahllsGYlllllhohFuP.....pthlulAaDSGGVTTuslTVPllhALGlGlAss.lp......GRssllDGFGLIAhASlsPllsVhlhGhlh	..........Ihhllhhhphhll....phshtp...hhpllhGhlhlhlG.LslFLhGlchuhhPlGcthGptlsp............................................................................hsp......hhhll.hhuFhlGFssTlAEPulhsluppspplos..GtIs...........ttslhhslulGVululsluhhRIlh.GhslhahllsGYlllllloh..asP......p.hlulAaDSGGVTTGslTVPhlhALulGlAus.lp...............u+.ss.hhDGFGllAhsSlsPlluVhlhGll.h.....	1	97	169	191
+7385	PF07557	Shugoshin_C		Shugoshin C terminus	Wood V, Studholme DJ, Watanabe Y	anon	[1]	Family	Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered [1]. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres [1].	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-6.83	0.72	-4.46	25	261	2009-01-15 18:05:59	2004-02-26 17:34:01	6	9	200	0	173	252	0	25.90	48	4.60	CHANGED	s.uRspR.Rsshsl.sYpEPoLpsKhRRs	.............sRspR..Rspts.V.sYpEPsLpsKhRRs..	0	42	82	135
+7386	PF07558	Shugoshin_N		Shugoshin N-terminal coiled-coil region	Coggill P	anon	Manual	Domain	The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C Pfam:PF07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore [1]. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly [2]. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [3].	30.00	30.00	30.00	31.90	29.90	29.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.98	0.72	-4.25	24	155	2009-01-15 18:05:59	2004-02-26 18:24:25	6	3	123	1	92	154	0	45.80	30	8.09	CHANGED	l+ppahpQNpplu+tNShlph+lpplcsclocLlsENhsLRpph.t	....lKc+ah+pNpElu+pNSh.sh+l..pplcscsopLhsEphslRppsl.....	0	15	37	67
+7387	PF07559	FlaE		Flagellar basal body protein FlaE	Yeats C	anon	Yeats C	Family	This family consists of several bacterial FlaE flagellar proteins. These  proteins are part of the flageller basal body rod complex.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.13	0.71	-3.48	180	2146	2009-09-11 11:36:52	2004-02-27 10:17:02	9	15	1789	5	472	1518	458	131.10	26	27.96	CHANGED	hss...ssssoas..sooh.slYDSLGss.........HslshaFs.K...................................sss.....ssW..plhssss.............................................................................................................................ss.s.ssslsFs.s.......sG...p....l.........................................................................sssssshsssssssuuss.p...............lslsh.........s.............................ssTQau....us..t..ssshs...Q.DGa	........................................ss.p.o.as....h.sso.l.slYDS.....hGs..s.........HslslYFsK....................................................................sus........Np..W.....pshs.p.ss.........................................................................................................................................................................................................................................................................................................................s.s.ss.s..shs.ssslpFs..s.........sG......sL...............................................................................................................................................................................s...ss..s.......s...s.....s...hs....s..s.....s.h....s..G.As.sts............hslsh.....................s..........................................................uh.T.Qhs......us...s.....lsshs.....p.sGY....................................................................................................................................................................................................................................................................................	0	138	279	374
+7388	PF07560	DUF1539		Domain of Unknown Function (DUF1539)	Yeats C	anon	Yeats C	Family	\N	21.10	21.10	21.80	24.40	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.50	0.71	-4.26	13	46	2009-01-15 18:05:59	2004-02-27 12:06:41	6	2	13	0	9	26	0	130.90	32	29.47	CHANGED	APpsssFLcSLhpsosppWpshpc........LcspIp......................cLsss..lcssWtpILchlsst......spsphsuc.spslhhuhha+LhphLp.....sPsIsp-+KpplLpaIuSYus.sCsPTWlEshhpElptlaNpp-susshl	..............sPtss.FLpSLhpsssppWshhap........LcspIp......................plpss..hcssWtsIlphlsst......ppsp.psc.sushhhuhha+lhthLp.........ssslop-+KhphLs.IuSYss.tCsPTWlEshhpElptIaNpp-pshs.l....	1	0	0	7
+7389	PF07561	DUF1540		Domain of Unknown Function (DUF1540)	Yeats C	anon	Yeats C	Family	This family has four conserved cysteines, which is suggestive of a metal binding function.	22.10	1.00	22.10	5.70	21.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.82	0.72	-3.92	185	1099	2009-11-12 09:41:43	2004-02-27 12:20:09	6	2	553	0	243	664	14	41.40	32	75.43	CHANGED	lpCpVssCta.Npspp.CsAspIpV.....u....................spu....ppspp.Ts..CtTF	...ltCpVssCsa..N.p..sst.Cs.Aps.IpVt....u.....................tpu.tpstpTs..CtTF.................................................	0	125	200	227
+7390	PF07562	NCD3G	ANF_assoc; 	Nine Cysteines Domain of family 3 GPCR	Liu XH, He Q, Studholme DJ	anon	[1]	Family	This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the Pfam:PF00003 in several receptor proteins.	25.40	25.40	25.50	25.70	25.20	25.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.97	0.72	-4.25	119	2732	2009-09-14 23:23:15	2004-02-27 13:11:15	9	24	148	9	1676	2202	0	52.60	41	6.74	CHANGED	PhSsCSpsC.sGptK...th.pGpshCCacChsCsssphssts.Dth.pChtCs.p...Wu	..............PpSlCS.psC...t..PG.hRK................th.cG..ps.....CCacChsC.s-sc...hs.....sp......s......Dt......pCh...p..Csts.pas..........................	0	120	276	1069
+7391	PF07563	DUF1541		Protein of unknown function (DUF1541)	Yeats C	anon	Yeats C	Family	This family consists of several hypothetical bacterial and occurs as a tandem repeat.	25.00	25.00	52.70	35.20	21.80	17.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.80	0.72	-4.29	25	328	2009-01-15 18:05:59	2004-03-01 10:17:26	6	3	151	8	58	283	0	52.60	52	56.99	CHANGED	psGspVllsAsHMcGMcGAcAsIcuAhcTTVYhVsYsPTsGGcpVcNHKWVsc	....sGspVhlpAsHMsGMKGApAsIcuAhc.TTlYsVsYpPTsGGcpVpNHKWVsp.......	0	16	43	51
+7392	PF07564	DUF1542		Domain of Unknown Function (DUF1542)	Yeats C	anon	Yeats C	Domain	This domain is found in several cell surface proteins. Some are involved in antibiotic resistance (e.g Swiss:Q9RL69 and Swiss:Q9LCJ9) [1] and/or cellular adhesion (e.g. Swiss:Q931R6) [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.37	0.72	-3.96	112	9196	2009-01-15 18:05:59	2004-03-01 17:55:50	6	178	465	0	319	6747	7	70.10	27	29.11	CHANGED	pppstIssssssTsEEKptAhsplspthppAhssIspAposspVsps......pspulssIp....sl...pss..spt....KssApp	..................phstIss..sssuTsEEKpsAhsplspth.spAhpsIs..s..A..s...T...........ssp...........Vsps...........cspulssIp......sl.....pss...sph......KtsAp.....................................	0	58	119	228
+7393	PF07565	Band_3_cyto		Band 3 cytoplasmic domain	Bateman A	anon	Pfam-B_1004 (release 3.0)	Domain	This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk). [1]	23.20	23.20	23.20	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.51	0.70	-4.87	32	1074	2012-10-02 23:31:29	2004-03-02 15:25:32	8	13	122	4	398	964	12	235.00	42	26.14	CHANGED	-l-csscRWu+PHVusLoa+SLhELR+sltpGsVLLDLctsoLsslActll-phlhpsplcspsRcplhcsLLh+Hp.......H.s-.........t.t..hshhhshushsp..t.................................t.sps.hs.spshtsp..tpttph....................................................................................phpphp.phhcKIPpsuEAosVLV.........GpV-FL-pPslAFVRLppuVh....LpulhEVPlPsRFlFlLLGP.sssshsYHElGRuhATLMoDclF+psAYtAcsRcDLLsuIc-FLDsulVLPPu-hssp	..............................................................................................................................................................cVEcsu-RWuKPaVAoLSh+SL....hELRp....sl.p...GslhLDhctso..........L.tl.................s.c...ll-p..l...ssplpsp...R.tpVhpsLLh+Hp.......Htsc......................hshhhS..hushsp...u.p.p.................................................................t..............t....s.......h..............tt...t..................................................................................................................................................t.phpphp.phhc.KI.P.tsAEAos.VLV................................GpV-FL-p..PhhA.F.VRLppA.Vh....L.suls.........E............VP..l.....Ps...RFLFlLLGP..tups.pY.H.E.IGRuhATLMoDc.........l.FH-sAYpAccR...........pDLl.uuI-EFLDpshVLPPGEh-s.s..................................................................	0	68	97	223
+7394	PF07566	DUF1543		Domain of Unknown Function (DUF1543)	Yeats C	anon	Yeats C	Domain	This domain is found as 1-2 copies in a small family of proteins of unknown function.	21.70	21.70	21.70	22.10	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.66	0.72	-4.45	44	345	2009-01-15 18:05:59	2004-03-03 13:14:42	7	2	198	16	80	277	231	53.00	32	53.00	CHANGED	splEhHDltaVVupslcsshspl+ppW....hGstpuLHlDuatplcpl....DGaclp......L	...t.hElHDhthsVusshp-Ah.ph+psW....hsst.pplHhDshpsVcss......tuhpl.....................	0	21	36	60
+7396	PF07568	HisKA_2		Histidine kinase	Studholme DJ	anon	BLAST	Domain	This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.61	0.72	-4.12	91	1811	2012-10-11 19:05:54	2004-03-03 17:01:18	7	326	1027	0	823	2166	242	75.40	34	13.93	CHANGED	EIHHRlKNNLQlISSLLsLQucphpsccs......hcsh+ESQsRVhShAllHEcLYcup...shcslsFusYlpcLspsLhpoY	......ElHHRVKNNLQsluSLLpLQ.u..cp.s.....p.s...s.c..s.......+psLp.-.utsRlpulAhlH-.t.Lh...ps.t......c.....p.........p...lshs.p.hlpplhppl....h...................................	0	296	586	667
+7397	PF07569	Hira		TUP1-like enhancer of split	Studholme DJ, Wood V	anon	Pfam-B_7106 (release 12.0)	Family	The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain Pfam:PF00400.	20.30	20.30	20.30	21.60	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.40	0.70	-5.13	34	350	2009-01-15 18:05:59	2004-03-04 09:39:21	6	28	250	0	246	360	0	188.80	25	21.31	CHANGED	sG+RlhPsllLsusssh..LEspupa.LhslTusGhLalWNlpptpshhss..SltslLs.s....t.....spusslotsplo.ppGhPllTLSNGcuYsasssltsW.hlo-sW..WuhuSpYWssh..............ssstst......................................ssssuhlshLEp+Tssphhhp...Gphh.hp+h........h+shl.ccGhEshE....psloluHLEN+ltsuhhLtupcEa+taLhhYs++Lupp..........Ghcs+lcElhppL	........................................................sG+RlhsslhLsu....hsh..lc.s...p...spa..lhslTssGhhhlW......s..lpp......t....ps......hhts.............S......lts.l.Ls...........................sssssl..spst.l.s..pp.G....h.P.l.l.s..L........o.......s..G.c.u......Yhas.shtsW.hlu-t....hh.supahssh.......stt..................................................ptu.lshlptpsppth....................................tshh.hps.pthp....p.holuaLEspltsuhhL.tutpE...a+haLhhYs+hL.stp..........G..c.+....lc-lhptL................................................................	0	78	140	211
+7399	PF07571	DUF1546		Protein of unknown function (DUF1546)	Studholme DJ, Wood V	anon	Pfam-B_3691 (release 12.0)	Family	Associated with Pfam:PF02969 in  Transcription initiation factor TFIID subunit 6 (TAF6).	20.30	20.30	20.50	20.70	20.20	18.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.00	0.72	-3.87	29	394	2009-01-15 18:05:59	2004-03-04 11:00:50	8	7	260	0	270	386	3	93.80	35	17.62	CHANGED	lLTCllu+pL...sspss......................hcppauLR-hAAsLLuhIs++ausshssLpP..Rls+ThlKshlDs........s+.shuoaYGAlhGLpsl.Gs-sl+hlllPpLpsa	...........................................llTCllu+pL..sspss..................................................hcs.HasLRDhAApLlup.Is..+p..auss.....hssLps...R....ls+ohhKshhDs.......................p+..shsopYGAlhGLttL..G..csl+hlllPpLp...................	0	93	145	215
+7400	PF07572	BCNT		Bucentaur or craniofacial development	Studholme D	anon	Pfam-B_10149 (release 12.0)	Family	Bucentaur or craniofacial development protein 1 (BCNT) in ruminents has a different domain architecture to that in mouse and human. For this reason it has been used as a model for molecular  evolution [1-3]. Both bovine and human BCNTs are phosphorylated by casein kinase II in vitro [4].	22.20	22.20	25.30	24.20	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.01	0.72	-4.04	37	295	2009-01-15 18:05:59	2004-03-04 11:32:09	7	6	263	0	214	299	2	78.80	36	26.19	CHANGED	K+......shlsplhutht......KcpKLsTLEKS+hDWsuas-cc.GIp....-ELphHs+.K.......cGYLs+p-FLsRs-s+p.Ep.+phRhpph	..................tp......shhsplluphs......KptK....loTLEKS+lDWssah-cc...GIp..........-E.Lph..+s+uK................-GYL-+psFLpRs-t+p.Etc+phRhpt.h.............	0	71	117	177
+7401	PF07573	AreA_N		Nitrogen regulatory protein AreA N terminus	Studholme DJ, Wood V	anon	Pfam-B_11486 (release 11.0)	Family	The AreA nitrogen regulatory protein proteins (which are  GATA type transcription factors) share a highly conserved N terminus and Pfam:PF00320 at the C terminus.	21.50	21.50	21.60	22.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.23	0.72	-3.42	7	19	2009-01-15 18:05:59	2004-03-04 13:21:54	6	2	18	0	9	21	0	82.60	56	9.91	CHANGED	MSGloh.GGGssusRPTtsAs.h.o..ssADADR................osQLSDDFShsSPhSssDSupspDGLLpDSLFPEW+sGAPRsGh-SPDE	........MSGloh.GGG.s..GusRPTpsAshh.oh.s.ADADR.Sssp..p........oSQLSDDFShGSPlSPsDSSpApDuLLpDSLFPEW+sGsPRs.GhDuPDE	0	1	2	6
+7402	PF07574	SMC_Nse1		Nse1 non-SMC component of SMC5-6 complex	Studholme DJ, Wood V	anon	Pfam-B_24547 (release 11.0)	Family	S. cerevisiae Nse1 (Swiss:Q07913) forms part of a complex with SMC5-SMC6 This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism [1,2].  It is conserved in eukaryotes from yeast to human.	22.00	22.00	22.30	22.40	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.14	0.71	-4.69	9	296	2009-01-15 18:05:59	2004-03-04 13:40:24	8	7	238	1	199	289	2	168.00	25	61.36	CHANGED	-s+RthLQslhs.+Ghlpps.ltphhsslsspps..s.h.ppt........hLssaVsplNpclpsLshclctspa............................ssutpaYValNssssstschuTsaossElpahKthl-tlspppshhtt........lshlstsscltupt.pp...............................................lt.ocsppLLpchsp.tWh.hohcschsLshRsLlEh	.......................cRthLQhhhs.+us.hp.pp....hptlh...t...th...hphpp....t.....t.............................ptlp.salssINstl.psht...hcI+pshp................................................p.suphhaul..VNhsss...s.h.o.p..hA.T.....sastsE........lshh+phl-tlhp..s.ts...s...tpt........s.hls.hptlphtp..tp.....................................................................pcsEphLpphlpptWh.h..p..pp.G..asLssRslhEh........................................................................................................	1	61	104	158
+7403	PF07575	Nucleopor_Nup85	Nuceloporin_Nup85; Nucelopor_Nup85; 	Nup85 Nucleoporin	Studholme DJ, Wood V	anon	Pfam-B_55990 (release 11.0)	Family	A family of nucleoporins conserved from yeast to human. THe nuclear pore complex is a large assembly composed of two essential complexes: the heptameric Nup84 complex and the heteromeric Nic96-containing complex.  The Nup84 complex is composed of one copy each of Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. The structure of a complex of Nup85 and Seh1 was solved [3]. The N-terminus of Nup85 is inserted and forms a three-stranded blade that completes the Seh1 6-bladed beta-propeller in trans. Following its N-terminal insertion blade, Nup85 forms a compact cuboid structure composed of 20 helices, with two distinct modules, referred to as crown and trunk [3].	19.70	19.70	19.80	19.80	19.20	19.50	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.93	0.70	-6.30	20	368	2009-01-15 18:05:59	2004-03-04 14:56:35	8	8	253	16	255	381	1	430.50	18	69.60	CHANGED	sshlYhlppstt.hposphRpllsEsaplFhsLQphc.......t.spspps......pal.plspsYRSllpsshpplpph.th...hhpc.tphpp......plolLhslcslWp....LhEhLah-ssstuslltpLL-Wl.Rhcspss-phsp.........-lLtppc.....slpcpssaWclVssLlLpGhh-pAhphL.tpcuph.........sspshhcshtsLLpphPhhp..tt.........shp-hcppWccW+spspc.......plpssshsspspLEsllpllsGsccslhp....hsssWYEhhsuhLLYhpP....osc.hE.LptYAppslsta..............s.ssspsh-plhlslhptclhpVltphpph.sshWhsAHlsDLl....-+sGlLp......spp.phu..............sshREaLLh-YApsLhS..c+oLWQlulsYlshssptG....+shlEhllsRlPlpTscct.+hLplCcphpLs-lsppIhKlhup+sLcps+hGsALsWhh+ApDhshlshlophlh.....cchspcGshhs.-llssluss.....................hlu.spLoFLupYp-Fa+hhpp.......ccatcAscLLlsLhpsphsPppaWhsLLsDslsLLp...ccsh.hssppThpllcsLEcht	.................................................................................s............................................................................................................................................................................................................................l....L.hpW..h.p...c.............tp..t.............phh..t..............tp..taW.p.h.l..hlh.G..hp.shthL...ttt.............................thhp.h....tlhpphP..t......................................................................th...th..p..hp...h......tp...........................pt.....h.t.......tlp.lhplh...hGp....t.th.t................p.sWhchh.shhha...s....................................p....hht..hp.h..........................................s..p.h.c.hh.hshh.phshtthlt.....h..........p....h...s.hh...ssthh-lh....................pht..thlt.................s............................shc.c.h...lhpYut.Lhs.............ppth..........Wplulthh......s....h..s....p.s.........thhlp.hl..+h..sh.....p.....o.....p...........p............p.......h......chl................pl...............st.pht.h..p.........pplhchhu.p............h....h.p..p.t.p......hG...pAl.hh.......h............p...........ups............h...........hhp.............l.....sp.h.hh.....................pph...ps....................t.hl..t.lhst..............................................hht...tLsh....h....s....phhcFhp......hhtp............................tph......tu......ph..Ll...lh................................................................................t..............................................................................................................	0	86	137	210
+7404	PF07576	BRAP2		BRCA1-associated protein 2	Studholme DJ, Wood V	anon	Pfam-B_5419 (release 11.0)	Family	These proteins include BRCA1-associated protein 2 (BRAP2), which binds nuclear localisation signals (NLSs) in vitro and in yeast two-hybrid screening [1]. These proteins share a region of sequence similarity at their N terminus.  They also have Pfam:PF02148 at the C terminus.	20.30	20.30	21.60	20.60	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.27	0.72	-4.48	8	297	2012-10-02 20:46:34	2004-03-04 15:41:04	7	12	249	0	215	297	3	104.60	28	17.78	CHANGED	ppssppphpsss.sthhslhsVsshhssc.lhphsuhppp.Icpl+ll+DusPNpaMVLI+F+sppsAhsFYppFNG+sFNslEs-s.CHllaVpcVEhspp....ssssss	..................s..........pp.ot.hhsl.hssshhhssc.L.h..hh.s.s..hppslp.p.h+l...l+..........c.up...s.NpYMVLlKFcspps.AcpFhppaNG+.F.NSh.Es.-s.C+llaVpplphpps..........s.....................	1	62	116	175
+7405	PF07577	DUF1547		Domain of Unknown Function (DUF1547)	Yeats C	anon	Yeats C	Family	This family appears to be found only in a small family of Chlamydia species.	25.00	25.00	48.60	25.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.73	0.72	-4.30	17	329	2009-09-10 18:55:26	2004-03-08 13:41:42	6	4	37	0	10	241	0	60.10	42	19.82	CHANGED	cILspVRpHLDsVYsupsst.stt....NQsLGslI+shE.ssTupsTllsshpssssshuop	DlLusVRtHLDhVYPu-ssssops....NQsLG-llpchEspGTupcTllos.puusspss............	0	3	3	7
+7406	PF07578	LAB_N		Lipid A Biosynthesis N-terminal domain	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of a group of Chlamydial Lipid A biosynthesis proteins. It is also found by itself in a family of proteins of unknown function.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.38	0.72	-4.06	10	310	2012-10-03 12:15:12	2004-03-08 16:42:16	6	3	227	0	109	288	189	71.50	40	47.27	CHANGED	lGhluphFFosRFslQWhhSE+ppcSslPtsFWhhSllGusLhLlYulh..puDsVhlLsauhsLllYlRNLpl	..lGhhuQhhFuhRFllQ.Wl.h.S.E+.t.p+SllPhsFWhhSl.hGuhhhLsYulh..+pDs.VhlLupuhulhlYhRNLh............	0	33	74	91
+7407	PF07579	DUF1548		Domain of Unknown Function (DUF1548)	Yeats C	anon	Yeats C	Family	This family appears to be found only in a small family of Chlamydia proteins.	22.20	22.20	23.70	44.80	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.65	0.71	-4.05	10	36	2009-01-15 18:05:59	2004-03-09 10:28:22	6	2	13	0	8	22	0	133.10	39	23.45	CHANGED	Rspc....EWHpIsuFKHh+GcpLGL.hDsLuc.LsshTlphTohphhpp+spYphlhppFlssY+sSsssLlpalhsQhlsSSp-lpsulpsaLL-sl.sslslPEs.c+sslls-lFY.D-s.YEhspEGIlYLLlh.GII	.............ppcEWHhhsuhKah+G+pLGLsh-pLsp.LsshTlp.TuhphhpppppYphlhspFlssYpsSsssLlshlhpphhsuos-hpsslpsalL-pl.cslslPEs.t+sslhpslFa.D-p..Y-hsppuIsYLLhh.sII.....	0	0	0	6
+7408	PF07580	Peptidase_M26_C		M26 IgA1-specific Metallo-endopeptidase C-terminal region	Studholme DJ, Yeats C	anon	Merops	Family	These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with Pfam:PF00746, they may be attached to the cell wall.	21.50	21.50	21.90	25.30	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	737	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.43	0.70	-6.23	18	836	2009-01-15 18:05:59	2004-03-09 12:20:28	9	67	284	0	22	447	2	617.60	40	40.45	CHANGED	spltEYslssh.sllYTPNtlh+D.pssLlssVhscLpuVpLpSs..sl+plL...s....hss-s.....s.......lc-LYL-ESFscVKssLschl+KLLps-sphhpss.psspphllcKIccNKsAlhLGLTYLNRaYshKYschslK-LhhFKPDFaGK.ssSsLDpLIclGpSu.sNL+ucpslpsYsphlusshGps.cLasaLch.R+LFsspps.N-WFKcsoK..AYlVEppSsl.EhpsKp..........htlY.....Dplsss..pappMlLPLLTLp.cpplFlISshsTluFuuaE.....+Ytpss.......cEtpphhccplccsAccQRsahDaWYRlhs-ss+-KLh+S.l.....VaDuashsssshh.c+hutsstcsshssl+EFF....GPsG+aathp.uh.GAYAsGp..........sVYahshchlsca.GsSsaTHEhTHssDphIYLGGaG+RpGhGsEsaApGLLQoPssssss....sLGlNhsac+psDss....plashDP.s+hpoccDlcpYM+Nh.DslhhLDYLEupullsphsss.pspWF+Kl-pcahcs........sspsathstVRsLTsEEtp..pLsSl-DLlDNsllopRshsuNt.......ca..csuYholshhusIYuuhsoSpGuPGslhF++sAFclhuhhGYccGFlsYlSNpYcspApppGpsh...........loDchllcKV.sGpaso.hp-FKKAha+EhhsKtp..slsslTls..........spTIsoas-LpsLhccAVpcDhtt....lpssssspp....stsppLKptlaKAhLcpTDsF..+oSIF	............................................................................pltEYslssh..sllYT.PNhh..ps..hspllpplhspLppVph.St.....tlpphl...s....hptps......p.......................................hpc.LYL-EpFspsKtpLpp.lppll.p.s-.tt.h..ss.pss.thlhcKl..cpNK..ttlhhuLTYLpRaYshpasp..hshKcLhha+..DFa..Gc.ssssLDp.lIplG..............Su......pNLhuppshpsYt..lutthspt.sLhshLch.hclFhspps.N-WFhptsK..sYlsE.p..Ss..-htscp..........htla..............Dtlsss....h....at.p......M..lLPLLsL...ptplalISshsohuauua-.....+Ytppp.........pp.tp.hc.pphccsActppsahDaW.+lh.sps+p+Lh+s.......la.Ds.hp...h...sst.t.....h....pth.h..sph.p.....p.s......ssh+pha....GPhsph...h.hp.th.GAhA.sh.........tVhahshchl.sc..GhssaTHEhTHssDp.lYhGGat+RpGhssEh....aApGhLQsPspssss........slslN.hhctppsss................ph.shsP.pchpstt-lppYh+sh.DslhhL-aLEupullt.....p.ptt.p.phh+Kl-pphhps.............tsht.hshlRpLst-Ehp..pLsShssLl-pshhop+t...ss............sa..psuYhslp..hhssIYuu.ssppGsPGsl.h++.sachhuhhGYccGFlsYlSNpYcppAcp.pGcsh...........loDchllcKl..s.....spapo.htsFKKshapEhl-Khp...slpslT.ls............spoIs.shpcLppLhscAVpcDht...........hhp..t...p........ptshpLKptlaKthLppTssF..psSIF.....................................................................................................	0	3	9	12
+7409	PF07581	Glug		The GLUG motif	Yeats C	anon	Yeats C	Family	This family is found in the IgA1 (M26) peptidases, which attached to the cell wall peptidoglycan by an amide bond ([1]). IgA1 protease selectively cleaves human IgA1 and  is likely to be a pathogenicity factor in some pathogens ([2]). This family is also found in various other contexts, including with Pfam:PF05860. It is named GLUG after the mostly conserved G-L-any-G motif.	20.50	18.00	20.50	18.00	20.40	17.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.22	0.73	-7.63	0.73	-3.40	110	564	2009-01-15 18:05:59	2004-03-09 12:56:16	7	70	210	0	192	551	145	27.50	37	4.06	CHANGED	sstslGGllGtstt.........uslpsssusu..sls	......sttlGGLVGhsht............usIpNuhAoG..sVs......	0	77	158	178
+7410	PF07582	AP_endonuc_2_N		AP endonuclease family 2 C terminus	Studholme DJ	anon	[1]	Family	This highly-conserved sequence is found at the C terminus of several apurinic/apyrimidinic (AP) endonucleases. in a range of Gram-positive and Gram-negative bacteria. See also Pfam:PF01261.	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.51	0.72	-4.42	56	878	2009-01-15 18:05:59	2004-03-10 15:21:13	7	3	742	7	289	741	345	53.10	34	16.20	CHANGED	-FcsIFSpLsphGYsGhsslEWEsslhctppGApEussFl+ch..lIpssstuFDsh	.....atslhSpLtthGYDGhlSlEaE.....D.....sl.....hs.....s-...c.....Ghpcusphl+sh...I.spstsh..h...........................	0	96	195	254
+7411	PF07583	PSCyt2	DUF1549; PSC2; 	Protein of unknown function (DUF1549)	Studholme DJ	anon	Blast single linkage clustering	Family	A family of paralogues in the planctomyces.	29.80	29.80	30.00	30.40	29.50	29.70	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.39	0.70	-4.83	176	580	2009-01-15 18:05:59	2004-03-10 15:58:43	6	38	66	0	247	688	957	204.70	35	22.91	CHANGED	ssIDpFlhp+L.cpt.slpPustA-.cpsllRRlshDLsGLPPT...scElcsF.....ls...D...p..u...ss..u.acc....lVD+....LL......sSP.c....YGE....+WupcWLDlsRau-opGh...p.c.......tp.ssatYRDaVlcuhNcshPYDpFlpEQLA.........GD.l...................t....................................pth........h.........................AouFht.t....................hptchh...sDtssssupsFLGloltCApCHcHKa.DPlopcDYYphtAaFs.sspttstt	....................................sIDpalhs.+Lc.pp...s..lpP..u....stAcc.psllRRlshDLsGLPPT..scElcsFls........D...s..s....ss...u.hcclVD+....LL......uSP.c....YGE....+WuppWhDlsRau-opGh.....p.s........p.....statYRDaVlcu.hNpshPaDpFlpEQlA......GD.l..s.......st...........................pph......h..........AouFhphs.............t............php.h...s-tssssupsFLGlo.ltCApCHDHKa.DP.l...........spcDYYphtAhFsssp....th.......................................	0	211	242	246
+7412	PF07584	BatA	DUF1550; 	Aerotolerance regulator N-terminal	Studholme DJ	anon	Blast clustering of Pirellula proteome	Domain	These proteins share a highly-conserved sequence at their N-terminus.  They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains [1]. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress [2].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.79	0.72	-3.79	193	1151	2009-09-10 21:46:21	2004-03-10 16:07:12	6	14	818	0	405	993	385	77.20	25	14.72	CHANGED	M..............Fh..sPh.hL................huLl.hlsl..lllahhhht+.pph..tasulphL.tphtppppp......phpphhLLlLRlLhluhlllAlApP	....................tFtsPh.hL.......hhLl.hlsl.....h..h...l...h..h...h...h..t...p+tpph....pFssh...plL....tplhspppp.......hp....a....l..hhh.LplLslshlllAlApP..................................	0	168	307	362
+7413	PF07585	DUF1551		Protein of unknown function (DUF1551)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of proteins identified in Rhodopirellula baltica.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.99	0.70	-5.57	14	57	2009-01-15 18:05:59	2004-03-10 16:13:21	6	2	20	0	35	65	47	311.20	17	65.17	CHANGED	pAEhlhhhpcGss.ssLlo.ss......s.sssss.s..sspsLhusphs.c..hpuGhRlphGhhhss.sshulEhpaaslts.suuhss...ssuphshhutPh.p.Tshss...ssuphl..h.s...........sthslpssschtuhEhNh.....Rhthss.........tts.phshLsGaRahpLc-tLphsps.sshst............shs..sso.l...s.p.shsscNphaGsQlGhphphpp.sthohsuhhKsulsss+tstsspsstshs.s...................s..sssshspsphuhlsEhslshtaplspshslplGYphlahssVshAs...cpIspshsssss............spssss.spsohhhpGlshGhpapa	..............................................................................................................................................sh.ss..s.p..hpsGhRhphuh..hts....slphph.....hhh..p.ptshts.....sstththht.tsh...s.hsh............tts.h.........................................sthphphpschh...uh-hsh...........ph.h......................tthphphlhGhRahplc-plshsssspt.st..............................................................s..sss.h......................p.shpspNph..a..Gs..QlGhchphph.spasls.shsKsul..hsNctphshp.spsshsts..............................ts......sstspsphuhss...-hslsh............tap..l...spphshphGYphlhhssVshu....pplstshssss................sth..ppsshhhpGhshGhph.a.......................................	0	28	32	32
+7414	PF07586	HXXSHH	DUF1552; 	Protein of unknown function (DUF1552)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of proteins identified in Rhodopirellula baltica.	19.80	19.80	19.80	20.20	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.11	0.70	-5.49	102	250	2009-01-15 18:05:59	2004-03-10 16:19:24	6	2	43	0	119	277	568	302.40	23	67.78	CHANGED	Rhlhlhhs.Glh..........stpa..hPp.........psGt..................sa............phsts..LpPLp...sh+cchsllsGlsp.tst......suHtsss.saLou.....h...tstst...hpss.lSlDQlhAppl....Gp..pTRasSLplusps..............tt.hss.slSas................psGp.....Plss..psPpplFc+LF.usssss........tttppp..hppcpSlLDtlhpcu+sl...pppLupsD..+pKLDpYhsolR-l..Epcl..........pptpthh........sh..t..Pthsht.s.................ss.shhpch.chhhDLhslAhpsD.TRVsThhhsss.........hhht.........tl.Gl..............stshH.slSHp...sss.ptht...phtphcpahspphuh	..................................................................RhshhhhstGsh.....................ppa...hPp...............ssGp...............................sh.............p.hsth...LpPLp...sh+schsllsGlsp.tst.............ssHtsss.shLTu......s...tsss...........thpsu.hSlDQhlAppl......up....pTphs.SLplusps..............st..hts.slSas................sssp.....Plss..psPpthFc+LF.usssss.............tttppp.............hppcpSlLDhVtp-scpL...pppLupsD..+pKLDpYhsulR-lEp+l.............pptptht.......st...h......Pphsht.s.......................tstshhpch.+lhhDlhslAhpsDhTRVsThh..huss................tth.hhs..............tl..Gl................................spsaH.slSHc........sss..ptht......phtplspahhpthu.............................	1	102	108	114
+7415	PF07587	PSD1	DUF1553; 	Protein of unknown function (DUF1553)	Studholme DJ	anon	Blast clustering of Pirellula genome	Family	A family of proteins found in Rhodopirellula baltica.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.68	0.70	-4.99	41	593	2009-01-15 18:05:59	2004-03-10 16:47:29	6	37	66	0	253	700	966	244.70	30	28.00	CHANGED	ssRhsLApWlsss-N...PLTARVhVNRlWpphFGp........Gl.Vcos-DFGhtGssPoHPELLDaLAtcFl-.sG.....WslKpLhRpIlhScTYppuSpss......scs........th.D....PsNchhuRhsh+RLsAEhlRDshLsloG...Ls.p.htGssh....s...........t........h.ts.stpphRRulYthhpRsh..............sshhpsFDtsststssspRppossP.hQALsLhNsshhhptup....thApplhpp............................................................................................tsss........ppplsthFttshuRtPospEhpthtshlsp	...................................................................................................t.pRhtLAcW.ls.ssc.N...PLs.ARVhVNRlWpphFGp........Gl.Vpos-DF.....Gh.....G......p.........P.o..H..PELLDaLAscFhc..ps............WslKpLhRhIlhSpsYppoSpss.......spt........................th..D....spN....phhuRhshpRLsA...E.lRDshLssoG.....Ls..p..ht..G.s.h...ts..............................................tt..h.RRul..Y....th...hpRsh....................sshhtsFDtss.t.p..s.s.spRpp.osss.hQALhlhNss.hhhctup....thup.p..hhpp..............................................................................................................................................................................................tt...........pp..tlpthahhshuRtPsspEhphhhphh..p.......................................................................................................	0	217	249	252
+7416	PF07588	DUF1554		Protein of unknown function (DUF1554)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of proteins identified in Leptospira interrogans. 	21.20	21.20	22.00	31.10	21.00	18.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.20	0.71	-4.71	15	119	2009-01-15 18:05:59	2004-03-10 16:55:52	6	6	18	0	20	123	4	148.20	36	48.04	CHANGED	sssssHNG..NaGGIoGADAaCp..uplPo.sLsusG..sYKAMLVD.s.....ssRhATossPNSosG..QhDWVhpPNppYpRuDsss.h.lhTTNusGlFsFs....LpNuFss....shpsshWTGLs.......ssWpThs........stsCss....Wso...................us.sshhGtaGsusp.psust	....................s..s.hHsG..shGGIuGADuaCp..uphPu...slsusG..sYKAMLVD.u.....ss..RhAsosssNussG....QhDWVhpPNppYpRu-.sss..h.lhTTNusGlFsFs......LpNsFss........hputhWTGLs.......ssWTThs........s.sCss..........Wss...................us.hshhGhhG.usthpsth....................................	1	13	18	18
+7417	PF07589	VPEP	DUF1555;	PEP-CTERM motif	Studholme DJ, Bateman A	anon	Blast clustering of Pirellula genome	Motif	This motif has been identified in a wide range of bacteria at their C-terminus.  It has been suggested that this is a protein sorting signal. Based on phylogenetic profiling it has been suggested that the EpsH family of proteins mediate this function [1].	20.70	18.00	20.70	18.50	20.60	17.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.59	0.73	-7.37	0.73	-3.88	163	1616	2009-09-11 20:23:54	2004-03-10 17:07:42	6	71	212	0	766	1794	370	25.50	40	9.66	CHANGED	sVPEPuo..hsLhulG..lhulsh.....hpR+	...sVPEPuo..huLluhG...Lsuluh.....htRR+........	1	297	677	745
+7418	PF07590	DUF1556		Protein of unknown function (DUF1556)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	\N	25.00	25.00	31.10	115.10	20.70	17.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.32	0.72	-3.75	3	3	2009-01-15 18:05:59	2004-03-10 17:11:44	6	1	1	0	3	3	0	93.70	37	69.21	CHANGED	MNQGSETTERIRTSSEGRMGAICRDGNLKLKTHRAhSVNPLPsNSSPupVV+SKRPtssSsAScPTtLpVRERsR....GulPpucFtpuoShpPtss	MNQGSETTERIRTSSEGRMGAICRDGNLKLKTHRAhSVNPLPsNSSPupVV+SKRPtssSsAScPTtLpVRERsR....GulPpucFtpuoShpPts..	0	3	3	3
+7419	PF07591	PT-HINT	DUF1557;	Pretoxin HINT domain	Studholme D, Zhang D, Iyer LM, Aravind, L	anon	Blast clustering of Leptospira proteome.	Family	A member of the HINT superfamily of proteases that is usually found N-terminal to the toxin module in polymorphic toxin systems. The  domain is predicted to function in releasing the toxin domain by  autoproteolysis [1].	25.60	25.60	25.60	25.60	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.62	0.71	-4.27	4	642	2012-10-03 10:25:13	2004-03-10 17:20:07	6	125	235	2	152	664	82	116.00	33	14.87	CHANGED	LVpTssGhpAIs+IpsGD+Vlups.pohcsuYKsVptpYsp.hpEhlalplsD.....psLlosc.HPFYsp.stalcApcLphGDcLlspsGshpsVpsIhlc..scPhKsYNlpVsDaHTYFVt.....TpGlWVHNu	...............................................tG.h.h.s.Itplps.G.D.Vhu..ts..t..o....sp...h.t....+.V..ht...h.a...s....p.........p.c...h...l.......l..pl.s.s..............................psl....h.s.st.HP......Fa.....s..p....................................t................t...W..........lpA..........t.cLp.sGsp..L........h.......s.p.s.......G............p..h..........s.V.p.s..h.th...c..............s..p..s.hpsYNLsVs.chHTYa..Vt.....sp...u....V..hV..HNt.............................	0	72	126	136
+7420	PF07592	DDE_Tnp_ISAZ013	Transposase_36;	Rhodopirellula transposase DDE domain	Studholme D	anon	Blast clustering of Pirellula proteome	Domain	These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.	22.50	22.50	22.50	23.80	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.82	0.70	-5.68	11	318	2012-10-03 01:22:09	2004-03-10 17:32:17	6	4	69	0	66	395	81	192.00	30	76.56	CHANGED	lpcLcuLl-ssTtGDPp..SsL+WTpKSspplucpL.pppGap....lutpsVucLLp.chGYSLQustKTppGspHPDR-sQFchINcplpphpssspPV.ISVDTKKKEllGsa+NsG+pWpppups.cVtsHDF.s.shGcssPYGlYDlssNpGaVsVGss+DTu-FAV-Sl+pWWpphG+c+YPcApcLlIsADsGGSNG.RsRhWKhcL.QcLusphGLsIpVCHaPPGsSKWNKIEHRhFSaISpNW+GpPLsoaEsllNLIuuTTTppGLpVpspLDcptYpsGlKVoDcphcslp..IpRsshHs-WNYpIpPp	........................................................................................................h.....................................................................................................................h..pht..lG...p.G..h............p................uhh......t......hs.s..s...s.hhsttlt.hW.......h.t.ppl.l.hDsG.spNs.h.p.ah.th..t.hutp.th.lplhahPPhpSKaN.lE.+has.lp.p.WpGp.L..shpshlth..tT..hT..pGlt..stl.pt.Y.hGhpl..sp..p..thtth.....h.ht..h.tWsh.l..........................	0	10	46	63
+7421	PF07593	UnbV_ASPIC		ASPIC and UnbV	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	This conserved sequence is found associated with Pfam:PF00515 in several paralogous proteins in Rhodopirellula baltica.  It is also found associated with Pfam:PF01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC Swiss:Q9NQ78) and in several other bacterial proteins (e.g. Swiss:Q84HN1 [1]).	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.31	0.72	-4.30	79	553	2009-01-15 18:05:59	2004-03-10 17:57:57	7	89	240	0	278	593	823	70.90	27	9.06	CHANGED	sAlGApVplp.ss...uppphppls....uGuGahu.psshpl+FGLGs..sssssplplpW..P.sGphpphpsl.s....sspphhll	...................AlGAcVpl...h..ss............uttp....hppls....sus.G.ahu.ps.pshlHFGLGp....sspssplclpW..P..sGp...h.pp..hpth..t.....ssphh...h..................	0	144	226	255
+7423	PF07595	Planc_extracel		Planctomycete extracellular	Studholme DJ	anon	Blast clustering of Pirellula proteome	Motif	This motif is conserved as the N terminus of several Rhodopirellula baltica proteins predicted to be extracellular.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.94	0.73	-7.26	0.73	-4.01	27	37	2009-09-16 17:53:18	2004-03-11 10:45:04	7	22	4	0	24	38	0	24.90	37	1.14	CHANGED	ppppppppsp+RRLthEsLEsRpLL	...pppppppsp+RRLthEsLEsRpLL	0	24	24	24
+7424	PF07596	SBP_bac_10	DUF1559; 	Protein of unknown function (DUF1559)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A large family of paralogous proteins apparently unique to planctomycetes.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.77	0.70	-4.37	147	1532	2009-01-15 18:05:59	2004-03-11 10:51:16	6	21	22	0	391	1685	425	209.30	20	68.30	CHANGED	QQAREAARRhpCsNNLKQlGLAlHNYH..DTatt.h...Psushssssssst.........................hs..........Wts...h..lLPalEQssl.a-ph....................shstshtsssssssstt................................ls...........sa......h.C.PScs............................................t.....ssssttsstsssssssstsssstsstssssGhhhhss..................thphpDl..pDGsSN.TlhluEpththsstststhh......................................................................sthststttssshshssssshsssssssssssttshsShHsG.Gsphh...huDGSV+F..lo-sl-hs	...............................................................................tAREAAR.RspCtNNLKQlGLA.hpsY.p...s.s.h.s.t....h.......P.sst.hss..sss.s....................................................................hs.......ahh.............lhP.a.h....-..pt.s.h..hp.t...h....................................p...t................................................................h.hh..C..Pop............................................................................................................................................................................................................................................t.t.th...DG.sp..shhh.E.........................................................................................................................................................................................................................t.p....t............-ut...........s.....................................................................................................................................................................................	0	391	391	391
+7425	PF07597	DUF1560		Protein of unknown function (DUF1560)	Studholme DJ	anon	Blast clustering of Pirellula genome	Family	Small family of short hypothetical proteins in Rhodopirellula baltica.	25.00	25.00	25.90	37.10	20.40	17.60	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.34	0.72	-3.96	2	4	2009-01-15 18:05:59	2004-03-11 11:09:06	6	1	2	0	3	4	0	38.50	75	69.06	CHANGED	C..shGhL+Ps.hs.Ro................ISVRSAcISVPLAALAEH	CVGNTGVLKPNIhsP+o................ISVRSAEISVPLAALAEH	0	3	3	3
+7426	PF07598	DUF1561		Protein of unknown function (DUF1561)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of paralogous proteins in Leptospira interrogans.	25.00	25.00	385.70	385.50	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.19	0.70	-6.57	23	62	2009-01-15 18:05:59	2004-03-11 11:15:06	6	1	10	0	31	64	0	608.70	54	98.82	CHANGED	Kl....Ll..hhhSlhl.....s.pTshsA.....lsspllQKPsDpP+DKsI+V.pVHsGtcYCYuPsFosGEuYIhIppCsp.pVhpARYDVFQRIuaNINsTWLChTAPpoVs....cuppsWDYlhLRPCsINDP.QRWIIK.....cNuFaTADt+aRlKDhsWYuYISKNuuDhYsHTLs.soMscWlpTlATPGNISl+T.IAWsh.os.G........ppYaIpssGSsp.ssTP..LYYNPENGHlAQY.PsSGslhCMhSp.ssspsWNWVpWthC..oD.....sl....SKcssuaWNl.hhssctGhIh.DYpGNhLRVT+YGosWGVsYTAKPsYLcpDTo..NSPTShFllspDl.cWsRYssuNLGcT.pYCPA.GpKcsls.....+pRlKR..oLPPDFpLT-pWl+RLa-IApSoo.....ssupppl.GhCGsChLpohQMLAELQEaHspsPLQsG.GYFFsTA.spDPFISFRQRaPtLsphLpss.shas.....ss.p.hspsppluhuuAhshLPQY-Wps.SshhpTcsEhhSclpsLlsuPsGolWhsllhcppsDG.shsGHA.PILRTspGLVlIPTNs.sshoL-paRpuLsPT....pDPppllsphhptus.psLt..sLsThQ.hstlhcsPhshhlSpRNCTGEG-cRRGoGchPpoohlNQCu...S....GRCu	.....h.hhhlhhl.lhh.......s..s.lsh....tls.pllQKPTD.P+DKsI+l.hlHsGupaCYuPsFosGESYIhI-pChp.pVhsARYDVFQRISYNINNTWLCITAPEoVl....+ucpsWDYVpLRPCTINDPLQRWIlK.....-NuFWTADt+YRLKDhsWYuYIS+NSGDpYsHTLs.sSMscWlpTlATPGNISIpTSIAWshto..u........pRYFI+ssGSsK.NTTP..LYYNPEsGHlAQYsPhSGsLhCMYSph.ss.pWNWVpWthC......oDt..sl.SKcN...PuFWNV..hts-cGGhIh.DYpGNhLRVTRYGsNWGVAYssKPsYlcpDTs..pSPTSLFllc+sLLcWsRYTsuNLGKT-QYCP.A.GpKEshh.....ppRlKR...oLPPDFQLTE-Wl+RLY-IApSss.....sssp.pph.GlCGlChLpoFQMLAELQEYHSpsPLQuG.GYFFDTAPspDPFISFRQRYPpLsphLpslsphas.........hspsphlshuoAhsMLPQYpWps.SsphsTRsEhhSHIpSLIsSPsGSlWLulhtppcsDG...ohsGHAlPILRTSQGLVVIsTNs.sshoL-pYRpsLsPT....pDPpplIss.hcpsspsL.t..pLsTlQ.LsphYpNsFDhhlSsRNCTGEG-DRRGoGpYPsSo.lNQCu..u....GRCs....	0	12	14	28
+7427	PF07599	DUF1563		Protein of unknown function (DUF1563)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A small family of short hypothetical proteins in Leptospira interrogans.	20.40	20.40	22.00	20.80	20.30	17.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.07	0.72	-4.08	2	16	2009-01-15 18:05:59	2004-03-11 13:20:55	6	2	6	0	7	10	1	36.70	74	15.61	CHANGED	MNIILIsFFLLETLENLYsTYVEh.LKQhFLDphQKI.KssRK	..MNIILIGFFLLETLENLYuTYVEh.LKQhFLDphQKI.KhspK..........	0	4	4	5
+7428	PF07600	DUF1564		Protein of unknown function (DUF1564)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of paralogous proteins in Leptospira interrogans. Several (e.g. Swiss:Q8F4V2) have been annotated as possible CopG-like transcriptional regulators (see Pfam:PF01402).	25.00	25.00	36.10	35.10	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.99	0.71	-4.92	14	111	2009-01-15 18:05:59	2004-03-11 13:28:11	6	1	7	0	32	122	0	159.80	35	92.35	CHANGED	McllhLsospclpSth.......tcppssssoLLIPcshh.pLscp..cpKsLppcls.LLK+YsKhlhopchltpcssKshYQps.h..cLK+hshRssstsWshLGlLAtsHGVSRChLFshLLhL-...shscSIspshstGsPsFpts...aphhhclshtpNplo+clpht.ps....hhh.l	.....................MthlhhssspclpSsh........cstsussoLLlPcshap+hstp......c+KsLpp+LPhLL++YsKhlsSh..cRLpp.+.As........KhpYpcssG.....chK+holRVpousWupLGsLAsAHGVSRCYLFNYLLhL-...t.ts.hlpThstGVPsFHhs...Yphh.hclshppN.loRcLphcPpsh...h............................................	0	24	24	24
+7430	PF07602	DUF1565		Protein of unknown function (DUF1565)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterised domains such as Pfam:PF00395 (e.g. Swiss:Q8YWJ6) and Pfam:PF03422 (e.g. Swiss:Q9FBS2).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.92	0.70	-5.23	8	240	2012-10-02 14:50:22	2004-03-11 14:07:11	6	32	169	0	75	498	272	161.50	28	24.64	CHANGED	lsGND.sssGo.cusPa+TIT+Alhhu+uss..lIplAPGsYssuoGEpFPlhlP-GVsLhGDEsuKGh....tslhhs.sh.hs+su..hIpGuu....sDls....hp.sTIlssNposIAGhsITNP....................s.....h+usulalpus.uspI+NNThou.shtcG..........Ips.........ssat.ssusuG.....Nl.......IoGNp......lt...........sphs.....GIuIsstpsu..h.....sKl.EN................N...lIsp.........Nth......G...Vs.sslu.hDLGsuSpsosGsNphSsNucpD.Iph..sspsspsL...hAhNNphD+.PPTl	.......................................................................tGsD.sssGo.pp....sPa..+T..I..spAl.p.h.A.tsGs.......slhl.tsGs.Y..st......p......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.t...................................................................................................................................................	0	39	58	69
+7431	PF07603	DUF1566		Protein of unknown function (DUF1566)	Studholme DJ	anon	Blast clustering of the Leptospira proteome	Family	These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	27.50	27.50	27.50	27.50	27.40	27.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.15	0.71	-4.39	70	852	2009-01-15 18:05:59	2004-03-11 17:18:20	6	68	343	0	265	776	364	132.00	20	39.54	CHANGED	sss.VpDppTGLhWp+Cs.G.th................tGsstthsWpsA.....lshs......sslsts...............shss.WRLPslcELtSl.....l....-hssh....sP.......ls..........spsFss......s............sshaWoSTs........tssst.....t..uWs.....lsass...Gtshh.......spssthhshhVRs	.............................................................s....lhD.hTsLhW...t..p.................................................tspsthh.sa.ppA........................hphs............pshsts..........................................GhssW..R......LPshp.......ELt.sL.......h..................chspt.......tst.................hs..............................sshFss.........s.....................sshaWou....os.........pstst.................t...uah...hsh.s........Gth..........thttt..hhh.l..s....................................................................................	0	112	193	238
+7434	PF07606	DUF1569		Protein of unknown function (DUF1569)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of hypothetical proteins identified in Rhodopirellula baltica.	20.80	20.80	20.80	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.79	0.71	-4.30	13	113	2012-10-02 14:44:17	2004-03-15 11:23:25	6	3	83	0	55	261	38	144.50	23	82.67	CHANGED	hsphtpLpassLpsAls-lppLppsuhpps..GsWsLuQlhpHLAtuh-hSl-GaPthhstlFt..+slh+hhahshht+GcMp...sLctshPuuh..ssslD-stslc+Ltpolp+FpsasGchsPH..AaGpLs+spachhHshHhtpHLpFlpPp	.......................................................................................thh............pphhsclp.pLp...p.s..ph......Gch...sluQhltHs.......s...ts.h...c........h....u...h....p.....s....h..s.h........t..s....h.ht.............phl..h.+..h.h..h..p........hh.h...p...sc..........pp..st..s..ts.s.t..h.....h..h....ss.....s....h.....-....h....c..p...p....h..p.cL..hp..t....lp...pa..p.......p...t....p.........s...s...h........t.........s........H...shFGcLopccWsphthpHlsHHLpQF...s....	0	30	48	53
+7435	PF07607	DUF1570		Protein of unknown function (DUF1570)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of hypothetical proteins in Rhodopirellula baltica. This family carries a highly conserved HExxH sequence motif characteristic of members of the Peptidase clan MA.	21.70	21.70	21.70	22.10	21.60	20.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.75	0.71	-4.14	9	34	2012-10-03 04:41:15	2004-03-15 11:53:20	6	4	13	0	18	107	21	125.70	27	27.92	CHANGED	slATlsHEAsHQlAaNsGlpsRhuc.PhWloEGLApaFEsschtsttuW+GlG.tlNphRlpp.acchhs.ccsuss.t...chIssDptFptsps...s.sAYupAWAlsaaLhcpchccaspalpplut+hPhp	....................................tTlhHEusHQl.saNhGltpRh..u.s....h.P..hWlsEGlApaFEsssh..p....tsth.pu..lG..tlNph+l....tt.h...c....phhs.tp..s...stsht............phl.hs.D.p..t.......F.ttspt.....stsu..YA..p..u..WuLsaaLh..p....p....c.......p..c...a.scaLppluph.sh......................................	0	16	17	17
+7436	PF07608	DUF1571		Protein of unknown function (DUF1571)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of paralogous proteins in Rhodopirellula baltica.	25.70	25.70	25.90	25.70	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.03	0.70	-5.21	4	69	2009-01-15 18:05:59	2004-03-15 11:58:36	6	1	57	0	23	72	16	195.40	40	60.37	CHANGED	hlK+Ep.lsGpLpEsphMslKlRs+.psttt.spPhSVYLpa.sPcohKGREVlYlEspN-GphlV+cGGhtGphl.Tlpl-PpGhLAMctpRYPIT-lGlcslhp+LIEhtc+Dl-ps....sscsshhcst+hcG+ssThlQl..spPo+css.sF+pAplaID-EhclPIphcuasWPs........sEs-pspLIEpYsYtDLplNsuLsss-FDsTN.cYpFc	.......................hlRQER.IuGch.u.s.P-pMhlKlp+p.........PLRVYAKWLPsGA+uGQElIYDsocRsDEMYGHLGGlLG+ls...hhhssDGsLARAQSNHpV+DLGsEalsshaLsEu+K....h..hEAG....sh+sTplEu+Tl.cGlRVlALTa..EoPsG+PQhhhpKcplh..lD.hc..sh.h..plEuY............................ss-.GclhE+lVa-cIs.p.s.L--osFDPcNPDY+F........................................................................	0	13	14	17
+7437	PF07609	DUF1572		Protein of unknown function (DUF1572)	Studholme D	anon	Blast search with Q7UW06	Motif	These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.15	0.71	-4.69	15	202	2012-10-02 14:44:17	2004-03-15 12:06:42	6	1	177	0	65	278	44	157.90	45	91.07	CHANGED	shup..sYLpsspppFcshKphG-+uluQLo-EpLphshs--sNSIAlIVKHluGNMhSRWTDFLT.....oDGEKssRNRDuEF-sshpo+pEllttW-cGWphlFsALssLss-DLpcTlhIRGEuHoVhpAIpRQlAHYuYHlGQlValuKhl+uscWpoLSIP+Gc	..........................................................................s..sppYlpsshppFcthKp.GE+sLuQLo....E.p.lpW.s.s.p.E.-.oNSIAlIlKHL...p...G...N...M...p...S...RW.T.D.F.L...T.........oD..G..E..K..h..s.R.N.R.....D...u...E.F-.s..s.h.p.o...K....c....E...l.....LtsWpc...GWp....hlF.ps..h.ss.Lss-cLh....p...s..V..h..I.....R....G.E....u.H....TV..h..p....A..IpRQ.....lu..HYuhHlGQIlYluKhLKps-WcsLSIP+Gp.......................................	2	30	53	61
+7438	PF07610	DUF1573		Protein of unknown function (DUF1573)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.	20.50	20.50	20.70	20.90	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-7.98	0.72	-4.38	99	698	2009-09-13 15:23:25	2004-03-15 12:54:42	6	12	236	0	193	676	292	45.00	38	20.45	CHANGED	sF.phpNsGcsPLlI..splpuSCGCTssphs+.cs......ItPGcp.uplpVpa	.....FphpNsGctPLlI..splpsSCGCTss.p.as..+.cP.....................ltPGcp.uplplsa...............	0	105	174	193
+7439	PF07611	DUF1574		Protein of unknown function (DUF1574)	Studholme DJ	anon	[1]	Family	A family of hypothetical proteins in Leptospira interrogans.	25.00	25.00	25.00	26.60	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.13	0.70	-5.58	4	48	2009-01-15 18:05:59	2004-03-15 12:59:46	6	2	10	0	17	40	4	313.40	24	92.76	CHANGED	Mh+KhaLhhPlLhFlhsFslDKlho.phhcsYhptuhshlaYchKcpLhpcLl.....c.pppsc-pKKlhlhFGsSRhh.FpssslcpK.hsDWhlYNFSuPsusPsYaLYaLE+lhssGlKPDhllh-.sP..Fsssoshhhc.sLtYuhDs.FlL+YhsphShpDhstahhs+LFtssh.pPchp.hhtRhK-tsh..h..uh.pshhltNLKpscusAhosu.s.V...spss-+LcccAh+hhs.hhssashushQhtFhtphLplsccpsl+shhlhPplhcshcchhpphch..........hc.WhsIlcpltEppuss.hsMsc.c..htCppa.DstHhSssCYpsahcFIlc+lsh	...................................................................................hpp.hlhhPhllhhhhFhlDKlhhlthlcs..hh.p..tths.hhYc.+.cplhpcLh..................cpp..tp..ttcp+KlhlhhGsSRsh.F............st.phl...c......cp..hs-....a.lYNFSsPsusPsYahYah..E+lhp.sGl.+PDhllh-hsP..Fspssshhhc.sLthuhs..Flhpahs................huhpc..........hphahhp+lFtsth.pPphp.hhtRh...p...stt...h.........th..pphhh.....sLpptct......sthssh......................ps.-p.Lp..ppu.p.h...hp.hhssaphu.hphtFhcphlphhccpsltshlhhPtl..shpchhcphph............hc.W.hshhppl.t...cph.shs.....hlshsp.c.th..pCptasDsuHhSssCa.t.hchlh.ph..h...........	0	5	13	13
+7441	PF07613	DUF1576		Protein of unknown function (DUF1576)	Yeats C	anon	Yeats C	Family	This small family is found in several undescribed proteins. The alignment is distinguished by the frequent occurrence of conserved glycine and aromatic residues.	25.00	25.00	34.30	26.70	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.25	0.71	-4.76	17	337	2009-01-15 18:05:59	2004-03-15 14:44:55	6	3	162	0	52	279	0	176.20	35	82.51	CHANGED	hlh.u...spp.hpGhhpIhppsuhLlTDahtlsGhGuoalNhGlLsll.hhhlhlhpsplNGPsluulhTlsGFuhFGKplhNlhPlllGlhlhulhpp.pshss..hllsuLFGTsLAPlsuph..............G.lhGIlsGFlh.slstshuhlHtGhNLYNsGFouGhlAhhlhsllcsa	.......................h.........pphhpGhhpIlpssuhLhTDahthsGhGushlNhGllsllshhhlhh.h.tsplNGPsluulholsGFShFGKplhNhhPIllGlhLhuhh...pp...pshsp..hllsuLFGTuLAPlsu.h..................GhhhGllhGalhsslstphthhHtGhNLYNsGFouGllAhhllsllc..........	0	34	48	52
+7442	PF07614	DUF1577		Protein of unknown function (DUF1577)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of hypothetical proteins in Leptospira interrogans.	25.00	25.00	56.60	56.00	22.00	21.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.60	0.70	-5.48	6	39	2009-01-15 18:05:59	2004-03-15 15:06:33	6	2	9	0	14	43	0	259.80	29	66.28	CHANGED	p+cHlIpKYLlpp-LhhKhss.ccchs.IhcllE-GpKIlhtsus.psls.sscllLYcILAKYlpLECsllcKh-sslhhlpVscluIA+ppRsssRhsV..-shalTNVloSKTl......I-ANhFsIP....T.VKVsFpDacs+LKpcp.shlplDl....FtsslscKFElV...............KKTcKhLaIcNTp..........DppSYtu.ss.shIchccEl..---lcspl+cYKcpcIh....SELIlPIlYlNcpcppI.PlGYlhlpo+Ep...slopppl.clppL	..............................................phh+lltcaLhtppl.hchs.ptpphh.lhchhc-uphIlh.s.pt.pshs.psclsLa+lLu+alpl-spllc.chcsplhhhplscltIApppRpssRlsl..s.shahsNllssKol......Ists.hsIs....TtV.cVpFpDhcp+lKpch.shhhIsl....atstlsccaElV...................K+ocKhlaIpsTs..........sppSYss.sppshlchtcEl..--tlcphhpca+spKI+....S.LIhPIlYhsctcptI.PlGYlhlpocpp...pIstppl..ltpL.......	0	5	9	9
+7443	PF07615	Ykof		YKOF-related Family	Yeats C	anon	Yeats C	Family	\N	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.68	0.72	-3.82	13	198	2012-10-01 20:40:01	2004-03-15 15:41:33	6	4	133	16	68	262	49	78.90	25	77.88	CHANGED	.uusQFSLYPM.ssDal-hIhusl-hhc..puslhscocchuTpLsGcstslFssLcslFhpsupsssHlslssTlStssPuc	....................ssphSLYPh.........s........s.....c...a.h.s.h.Ih.sslctlc......psslhhp.oss.huTtlpGchppVasslpshattutp.p....HhshphshShtsPs........................	0	21	47	56
+7445	PF07617	DUF1579		Protein of unknown function (DUF1579)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Sinorhizobium meliloti and Agrobacterium tumefaciens.	20.70	20.70	20.80	21.90	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.95	0.71	-4.58	17	94	2009-01-15 18:05:59	2004-03-16 15:14:49	6	1	86	0	51	110	25	150.90	25	89.46	CHANGED	hs.cPppEHpWLpcllGpWsh-s....-s.MsP-pPspcspuhppVRp.lGGhWl.s-upGcMs.....t.GsshsolhTLGYDss+pcaVGTWlGSMMothWlYcGpLDpss+sLsLpuEGPshss.....sG+hupYRDVlphhDsscRshoSthhsp-GpWhphMsupY+Rp..c	...............h..psttpHphLppl...lGcWssps....chhh...sPsps.......st.psp.hptss+..l.sG.hallp-sp......Gphs........Gps..hpslhslGYDstppcaluoWlsS..Mhst..hhhhcGp..hsts.sp.slsLpspsssht.......sG.h.hpa+chhphh.sssphshp..h.t..t..sGphhphhphpapR..h..................................................................	0	23	32	41
+7446	PF07618	DUF1580		Protein of unknown function (DUF1580)	Studholme DJ	anon	Blast clustering of Pirelllula proteome	Family	A family of short hypothetical proteins found in Rhodopirellula baltica.	22.90	22.90	23.60	24.70	22.30	22.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.48	0.72	-4.60	5	10	2009-01-15 18:05:59	2004-03-16 15:20:36	6	1	3	0	6	14	0	53.60	34	55.43	CHANGED	PLLcAlcLEoGhRPusSTlhRWuh+PNRHGNhLcoWhlGGR.RhTSVpAV+RYlcAsT	.........shhphhc.psG.RsHsSTshRWsh+ss+pGshLcohhlGGR.RhTSVpAVpRalcsss...	0	6	6	6
+7447	PF07619	DUF1581		Protein of unknown function (DUF1581)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	Several Rhodopirellula baltica proteins share this probable domain. Most of these proteins are predicted to be secreted or membrane-associated.	20.50	20.50	21.00	29.10	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.89	0.72	-4.00	7	15	2009-01-15 18:05:59	2004-03-16 15:26:38	6	4	2	0	8	16	0	83.90	35	7.17	CHANGED	Rssl+Dspppshl..NGR.lppcslhssusPWlulRu.hpsputhRNL+IsGsPplPsplshlsutpLhGW.ssYasts....tsp.tGph	..Rssl+Dspspshl..NGR.lpp-sltssusPWlulRuphpsputhRNL+ITGsPpIPcplshlsuspLpGW.ssYasts....tsc..sp.........	0	8	8	8
+7448	PF07620	SLEI_Leptospira		SLEI	Studholme DJ	anon	Blast clustering of Leptospira proteome	Motif	This highly conserved sequence motif is found at the C terminus of several short hypothetical proteins in Leptospira spp and related organisms.	16.20	16.20	16.50	17.80	16.10	16.10	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.85	0.74	-6.21	0.74	-3.76	10	31	2009-01-15 18:05:59	2004-03-16 15:31:40	6	4	30	0	4	38	0	15.30	65	4.13	CHANGED	stphLRDNSLEISNph	I.IMEE.GNSLEISRQM...	2	2	2	3
+7449	PF07621	DUF1582		Protein of unknown function (DUF1582)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of hypothetical proteins in Rhodopirellula baltica.	25.00	25.00	26.60	40.60	23.80	18.90	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.84	0.73	-7.06	0.73	-3.70	5	9	2009-09-11 06:28:21	2004-03-16 15:42:10	6	2	1	0	9	9	0	28.90	38	19.74	CHANGED	RuLPSPcsLs-pRlscsssCsscG.tsLA	..RsLPSPc..hstRlss.ssCspcG.hsLu.	0	9	9	9
+7450	PF07622	DUF1583		Protein of unknown function (DUF1583)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	Most of these Rhodopirellula baltica hypothetical proteins also match Pfam:PF07619.	22.80	22.80	22.80	35.40	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.24	0.70	-6.01	6	21	2009-01-15 18:05:59	2004-03-16 15:48:41	6	5	2	0	11	21	4	306.00	25	36.07	CHANGED	tltGSphESLLpYhRPlh-sspIEYEFFYDsGpsusHPAlsRhAhLIcs-GVu.H.hTDGtappo.LRPDNthhh.p.tpcpuslPL+sspWN+scLphtG-clpLpLNGpsIaEpsl-sps.sRsFGLFHFuDpopl+VRsLpLSGDWPppL..hspQpLAsshsscLctssscLspsFpHDFcc.shsschF.tpst..scshhss--Gl+hstuo.usacphshsPphplcGDFDlTAcFsthQsss.Ess.huulthplsL-sstpcpl...tsspthscppGp+lhsshphphssGpt.ppthst+psp-uTSG+LRlsRRG-plaaLFApsDSspF+LltpEpsscuslssuGIpL.sslssssGosSupWsslolRAEcl...ssusPDhpssLu..plc.s+st	...............tLL.YhRPhhcttplpYpFaat.spstsaPslsRhshhlp.sGht.p.hp.s...t.s.h.ssNh.h......t.sshs.psptWNphcl.h.sspl.lpLNtp.lhpt.lps.t.s.pFGLa+.tcppthhhpshhhpGcWPttl.....p.hs....tpLttthptLspsapaDFpc.t.sschF.thst..stsh.ts-cGlphptsu.s.apthsls.phtlcGDFDlshpFs.hph.s.tss...stlthplphssstpspl....hhhthsttts.phhtthphthssGp..phhhshthp.s.usushLRlsRRG-plahLhuptssp.hplltppphsptsl..hslph.h.h.s.stsspsss.hhpplpl+Acpl........................s..........	0	11	11	11
+7451	PF07623	PEGSRP	DUF1584; 	Protein of unknown function (DUF1584)	Studholme D	anon	Blast clustering of Pirellula proteome	Motif	This sequence motif is highly conserved in several short hypothetical proteins in Rhodopirellula baltica. It also is associated with Pfam:PF07621 in Swiss:Q7UJJ9.	25.00	25.00	29.60	28.80	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.04	0.72	-4.64	6	15	2009-01-15 18:05:59	2004-03-16 15:59:05	6	2	2	0	14	15	0	26.50	76	24.92	CHANGED	LAVhRKPPGEEPEGSRPSATSLVVHVV	.LAVhRKPPGccPEGSRPSATSLVVHVV	0	14	14	14
+7452	PF07624	PSD2	DUF1585; 	Protein of unknown function (DUF1585)	Studholme DJ	anon	Blast clustering of Pirellula proteome 	Family	A conserved sequence region at the C terminus of several cytochrome-like proteins in Rhodopirellula baltica.	21.40	21.40	21.40	21.70	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.26	0.72	-4.32	63	199	2009-01-15 18:05:59	2004-03-16 16:05:40	6	17	35	0	86	222	297	75.30	25	9.62	CHANGED	ssGppFpshtpl+phLhpc.p-pFscslsc+LlsYALGRslphsDcstl-pIhsphcpssaphpsllptlVpSc.Fp	................sGppFssht-L+phLhpp.tcphscshsc+llsYAlGRslp.htDcstlcplhpphppssaphpsLltslVpSp.Fp....	0	79	80	83
+7453	PF07625	DUF1586		Protein of unknown function (DUF1586)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of short hypothetical proteins in Rhodopirellula baltica.	20.80	20.80	21.50	22.30	18.60	19.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.62	0.72	-6.59	0.72	-4.12	3	11	2009-01-15 18:05:59	2004-03-16 16:08:24	6	1	1	0	11	11	0	21.80	73	40.82	CHANGED	SRTALAAVSQTPTGANAcWHLL	SRTALAAVSQTPTGANAaRhll	0	11	11	11
+7454	PF07626	PSD3	DUF1587; 	Protein of unknown function (DUF1587)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07624.	21.10	21.10	21.10	21.40	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.00	0.72	-3.97	66	193	2009-01-15 18:05:59	2004-03-16 16:12:43	6	25	37	0	90	219	315	67.80	31	8.22	CHANGED	RRLs+pEYpNTl+DLLGlc...hshsp....thPsD.ssspGFcNsGpsLthSshphEpYhpsAcphlcpAhhpss	...........RRLs+tEYpNTl+DLlGls....hshsp.............thPsD.ssstG..F-NsussL.s..l.Sshhh-pYhpuAcplhspAhh..s.................	0	78	83	87
+7455	PF07627	PSCyt3	DUF1588; PSC1; 	Protein of unknown function (DUF1588)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07626 and Pfam:PF07624.	21.40	21.40	21.40	21.50	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.39	0.72	-4.16	92	252	2009-01-15 18:05:59	2004-03-16 16:17:41	6	38	43	0	118	280	421	101.80	36	12.41	CHANGED	pRGGlLspuulLshsosuscoSP..lpRGsWlh-plLssssPsPPs.sVs....slpsstsst.........TlR-pl.thH.ppsssCuuCHp.clDPlGauhEsFDslGpaRsppsst	....................RuGlLopuulLshsussscoSP..lpRGhWlhcplLs.pssPPPPs.sVs.......sltsstsss...............ThR-pl..ptH....ppss..sC.u.uCHp.plDPlGauhEsFDslGpaRsp-t.t.....	0	101	107	114
+7456	PF07628	DUF1589		Protein of unknown function (DUF1589)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of short hypothetical proteins in Rhodopirellula baltica.	20.60	20.60	21.50	21.40	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.01	0.71	-4.33	2	15	2009-01-15 18:05:59	2004-03-16 16:24:54	6	1	2	0	13	15	0	82.70	31	79.55	CHANGED	MLWN+AuRPAGHARLSDVRPFT.PGTTWPT.LSQPDASARDTSEFWRSHQRR.GHYLAPSRpFGTKRAVQPVTQsSAMSVHSPRQVQPGLHhCPNPTRQRcTRLNoGEATNVGQVITWHPADALEQStPSSRSRKTQRCPSIHPARYNLsYI.VPTRRVSEtHV	.......................................................................................+..R.sahhtPSRpFtTKRuV.................................................................................................................	0	13	13	13
+7457	PF07629	DUF1590		Protein of unknown function (DUF1590)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These hypothetical proteins in Rhodopirellula baltica have a conserved C terminal region.	25.00	25.00	78.70	78.10	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.51	0.72	-4.35	2	5	2009-09-11 20:23:00	2004-03-16 16:28:30	6	1	1	0	5	5	0	32.00	88	26.02	CHANGED	MtsGAchPPPEISLNAhFPTPPAApAtFSRlh	MENGADCPPPEISLNARFPTPPAARAGFSRRY	0	5	5	5
+7459	PF07631	PSD4	DUF1592; 	Protein of unknown function (DUF1592)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07627, Pfam:PF07626, and Pfam:PF07624.	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.48	0.71	-3.77	85	245	2009-01-15 18:05:59	2004-03-16 16:52:12	6	37	41	0	113	273	427	126.60	31	15.60	CHANGED	LssaELAoRLSYFLWuShPDpc.LhphAppucL.p...ssphLcpQlcRMLsDs+u..cphspsFssQW.Lshc.plsphs..ctpha.s.pa......ssp.........lcpuhppEshpFhppl.lccs..tslpcLlsuDao.alNppLAca.YGl	...........................................................................................LssaElAoRLSYaLWuShPDcp.LhphAppGc.Lp....sspslptQscRMLs.D.s.+u....cthspsFstQW.Lplc......pls....p...hs....Dtpha..spa................ssp...........................lppshppE...sptah.ppl..lccs..ts.ltcL.lsu-as.alNppLApa.YGl............	0	99	105	110
+7460	PF07632	DUF1593		Protein of unknown function (DUF1593)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of proteins in Rhodopirellula baltica that are predicted to be secreted. Also, a member has been identified in Caulobacter crescentus (Swiss:Q9AAT9). These proteins mat be related to Pfam:PF01156.	42.90	42.90	50.40	43.20	42.80	40.80	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.91	0.70	-5.08	29	158	2009-01-15 18:05:59	2004-03-16 17:00:58	6	7	98	1	97	173	8	254.30	37	53.54	CHANGED	RllVhTD..lts.EPDDtpSLVRhLLYuNch-lEGllsooS....hahpsp..............................spsc.lpc.l...lcAYucVhPNLtpHsss..............YPos-hL+SllphGt.s..................uh.shGpsps.osGSphIlptlpc.s-s..cPLal.sWGGsNsLApALhplcpphstpp.....hpplhsKlRVYsIuDQD.........-s.usWIcppaPc.lhYItu..hpsh.ththssWsshssph..........p.phhopsW..lpppIpp.hGPLGuhYPs........................................hpahs........EGDTPuFLaLlssGLssP-pPsaGuW.GGRa	...............................RlhlhTD..lts...EPDDtpShlRhLlYuNph-lEGlluooS....hahtsp..........................................stsp.lpc.l...lc.uYtclhsNLppHsps..............YP...os-hLpullppGt.s....................................s.htslGpsps.opGSphllptlp...........c..sss..cPLWl.sWGGsNsLAQALhplcpphsstp.....htchhsKlRlYsIuD...QD.........-s.usWIcppaPc.lhaIts...hhshtt..hhhtsWsshssph..............p.phhsppW..lcpsIpt.tGPLGs.t.YPs.........................................h..ta...h.h........EGDTPoFLhLlpN...GLss..s-cPsaGuW.GGRa..........................................	0	34	63	88
+7462	PF07634	RtxA		RtxA repeat	Yeats C	anon	Yeats C	Repeat	This short repeat is found in the RtxA toxin family [1].	20.80	5.00	28.70	5.00	18.20	4.90	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.46	0.74	-6.50	0.74	-3.24	99	3103	2009-01-15 18:05:59	2004-03-16 17:20:41	6	42	64	0	556	2748	47	18.50	35	20.18	CHANGED	utGsuNlls+s......Gsssslsh	.....hhGtuNllT+l.......GsGsslt..........	0	42	271	437
+7463	PF07635	PSCyt1	Cytochrom_C_p; PSC3; 	Planctomycete cytochrome C	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These proteins share a region of homology at their N-terminus that contains the C-{CPWHF}-{CPWR}-C-H-{CFYW} motif typical of cytochromes C, or CxxCH.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.27	0.72	-3.65	141	688	2012-10-03 10:02:11	2004-03-16 17:24:33	6	75	104	0	304	822	1079	58.40	31	7.34	CHANGED	CapCHGscpp..cusLcLDstsshht....sspsG......sullPGcscpS.L.hpplt.spcpshpMPPsc	.ChpCHusspp........cusLcL-shpshhp.....................sspsG........ssllP.Gcs.cpS.L.hpp.lt....sp...s.........s.s..p....MPP...........	0	232	290	300
+7464	PF07636	PSRT		PSRT	Studholme DJ	anon	Blast clustering of Pirellula proteome	Motif	This motif is found at the N terminus of several short hypothetical proteins in Rhodopirellula baltica and the predicted Arylsulfatase B (EC:3.1.6.12) Swiss:Q7UX97.	20.20	20.20	25.50	24.50	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.40	0.72	-4.48	4	7	2009-01-15 18:05:59	2004-03-16 17:31:57	6	2	1	0	7	7	0	30.60	59	19.12	CHANGED	cGNptpaHARPSPSRTPERRRSo.PQTphRER	.......ushhp.HARPsPSRTPERRRSoSPQTphRER	0	7	7	7
+7465	PF07637	PSD5	DUF1595; 	Protein of unknown function (DUF1595)	Studholme DJ	anon	Blast clustering of Pirellula proteome 	Family	A family of proteins in Rhodopirellula baltica, associated with Pfam:PF07635, Pfam:PF07626, Pfam:PF07631, Pfam:PF07627, and Pfam:PF07624.	21.20	21.20	21.20	22.00	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-9.09	0.72	-3.93	81	218	2009-01-15 18:05:59	2004-03-16 17:41:47	6	29	39	0	105	247	304	63.60	29	7.82	CHANGED	tpu+..phlppFup+AaRRPlsss-.lstlhslacpttpp....upsapp.......ulctsltslLsSPpFLY.hsEt	......pucphlppFupRAaRRPlsssE..lpphhslappstpt......stshpp.......ulchslpulLsSPpFLYhsE.....	0	91	97	102
+7466	PF07638	Sigma70_ECF		ECF sigma factor	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These proteins are probably RNA polymerase sigma factors belonging to the extra-cytoplasmic function (ECF) subfamily [1] and show sequence similarity to Pfam:PF04542 and Pfam:PF04545.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.04	0.71	-4.62	7	258	2012-10-04 14:01:12	2004-03-16 17:52:40	6	7	143	0	120	8136	1123	167.30	21	87.84	CHANGED	.pcloplLpplcsGDstAsstLh.hlYp-LRRhAtsph.psE+hspsLpsoAL.Va-AalRhlstpch.chsuRsahauhuscsMRRILl-pARRcpppKRGGchhRtpLsp..ss.......hc.................sss-.lLsL--uLppLhs.hsPcpt+lVELRhFsGLohcEhAphLslShRTlcRpWthAR.sWhtpchps	..............................................................................................................................................h.l.tt.h...p.t..G.s..t.A.h.p..t....L.h.hh.a..pL.+.p..h.A.t.t.......h.......h....p...t...t..t.................s...t..s...................p.....s.........s.s..L...l.p..-.u.a..l...+...h......h...p............t.............p......h...p....s..........c....t...c....a....h.......t....h.....h.s....p.....h....h.....R...p.....h....l....l..D...t..t...R....p........p......t........s.......t.......K...........R.........t.........s......t....h.........h...h...p....l....t..t......t.............................t.t.................................................t.p......c....p....l....l.....t.......l.....c......c.....u.....L.....p.....p.......L.....t....p.....hs..s....c....p....t....c....h.l.p...L.p....a....h..s........G.....h..o..hpE....lAphL..s....l....S.....p....o....l....c....+....c....h....p.....hu....R..shlttt...t...................................................................................	0	83	100	112
+7467	PF07639	YTV		YTV	Studholme DJ	anon	Blast clustering of Pirellula proteome	Repeat	These hypothetical proteins in Rhodopirellula baltica contain several repeats of a sequence whose core is the residues YTV.	21.00	21.00	22.30	21.00	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.64	0.72	-4.23	18	108	2009-01-15 18:05:59	2004-03-16 18:00:16	6	10	10	0	52	113	196	43.40	40	33.91	CHANGED	oYTVphPVhETcp+shpYoVp+PVaETpsp..sYTVpVPshET+sp	......................YTVp+PVhETpp+shpYTVp+PVhETppc..sYTVp..+PVhETh.........	0	52	52	52
+7468	PF07640	QPP		QPP	Studholme D	anon	Blast clustering of Pirellula proteome	Motif	These Rhodopirellula baltica proteins share a highly conserved sequence, centred around an invariant QPP motif, at their N termini.  This motif may represent an export signal.	25.00	25.00	57.60	57.60	17.20	16.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-7.87	0.72	-4.28	9	11	2009-01-15 18:05:59	2004-03-16 18:04:46	6	4	2	0	9	11	0	36.00	49	13.76	CHANGED	MASsQPPLTRCGShNQQPspshpssttspph.s.ss	MASsQPPLTRCGShNQQPspuhpssthspph.shs..	0	9	9	9
+7470	PF07642	DUF1597		Outer membrane protein family (DUF1597)	Studholme DJ, Bateman A	anon	Blast clustering of Pirellula proteome	Family	This family of proteins are likely to be outer membrane beta barrel proteins. Possibly acting as porins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.28	0.70	-5.42	89	396	2012-10-03 17:14:37	2004-03-16 18:17:17	6	1	220	0	175	591	194	345.70	18	84.83	CHANGED	slpluGhl-shaphshsps.tst.....................hssps..sphsls.s.lhhptsssp......hshthslhaGstut.s.hs................................tsthhhsl.pAYssht....hscslslssGpasThlGaEsh.shsNhsao+uhhhp.s.PahcoGl+ssYssss.phshhhulhsG.....h................p.h...........ssss....t.shssplsa..tsstphslshshhhGsps.....t............................spssphh...hslsssaplss........phplshshsashtptt......................sssssssaaGssh...................................ahp..Yshs-...phuluhRsEaapsps...............................shsssssspshuhTlsssap................tsslhlRsEhRhs......p....stst........h..Fhps.ssps.......................spsthshssshtF	...........................................................................t.hphtGhlpshh.hs..sp...tst...................................hssps.........sphplst..h.lhhppssst..................hshhhphhhGstuths.hh...................................psththsl.pAalpht.....ht.p.s..lslphGphhohhGh.Esh...s...hs...N.h.a...o...t...u....hh.....hph..t.P..ah..psGlhs.sa..t.hss....phsh..hhulssG...............h.....................................................................psh.........................psss.............t.shhstl.sa...t.ssph..s..lt..hsshh..Gsps.....st.....................................................ststphh........hslhh.saph...s...c..............................p.hslsh..phs.ahtppt.............................s.stsss.haGssh...................................................................ahp........Ys..hsc.......phsls.......h...Rs.Ehapcsst.............................................................hsh.h.ss.ssss...h.h..shT.lsssap.........................................hsshhlRsEhRhc............p.......utss........s....hs.s.sst.........................sthhhshshhh.F...................................................................................	0	76	146	161
+7471	PF07643	DUF1598		Protein of unknown function (DUF1598)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of Rhodopirellula baltica hypothetical proteins of about 500 amino acids in length.	25.00	25.00	34.60	77.50	24.30	19.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.80	0.72	-3.95	9	18	2009-01-15 18:05:59	2004-03-17 09:12:34	6	1	9	0	8	18	20	83.70	38	16.70	CHANGED	CSIDPssEGLt+hppalpplsst....uthsstt...hhpshcpsLGhQ-lpVhGlssso+aARlLVEADY+MKRIuhGh-psslt.l.SY	CSIDPs.EGLp+hppalpplssp....sshsstt...hhssLcpsLGhQ-lpVhGlssco+hARlLVEADY+MKhIuhGl-psslt.lsSY.	0	8	8	8
+7472	PF07644	PGAMP		Planctomycete PGAMP	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	This conserved sequence is centred around an invariant motif of PGAMP in several short hypothetical proteins from  the planctomycete Rhodopirellula baltica. The motif also occurs twice in Swiss Q7UVK9.	20.30	20.30	43.70	43.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.85	0.72	-4.21	4	8	2009-01-15 18:05:59	2004-03-17 09:31:05	6	3	2	0	5	8	0	34.80	52	15.43	CHANGED	SlplPGAMP.AohphAhGQpsRhtpuQpppSphus	.SlplPGAMP.AoMphAVGQpsRhtKuQtQpSphus	0	5	5	5
+7473	PF07645	EGF_CA		Calcium-binding EGF domain	Bateman A	anon	Pfam-B_330 (release 10.0) 	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.08	0.72	-3.96	18	24503	2012-10-03 09:47:55	2004-03-17 16:01:14	10	2919	264	49	14019	30190	160	41.60	36	11.43	CHANGED	DlDECss.ss.psC...ttsshChNshGSFpCh....C.sGap......stssspsC	..................DlDE.C......t.........p........s........s.....t................C.............t.t...u..pCh...N...o.........G..S...a....p......Cp.....................C.....s..G.ap...............tt......................................................	0	4262	5341	9307
+7474	PF07646	Kelch_2		Kelch motif	Finn RD	anon	Context Domains	Repeat	The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.22	0.73	-8.44	0.73	-4.00	42	698	2012-10-05 17:30:42	2004-03-17 16:09:08	10	211	235	0	334	6336	157	51.00	22	11.00	CHANGED	sphstsss.sh.......ssclhlhGGh...................s....phhhhcsppppWpphsshs	...................pssauss..sh............ss+l.hlaGG..h................................................................ttt.t.s..p...h..........s.-..l...h...hhD..h..pphpWpphp........................	0	102	166	239
+7475	PF07647	SAM_2		SAM domain (Sterile alpha motif)	Finn RD	anon	Manual	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.10	0.72	-4.13	49	3625	2012-10-02 20:42:54	2004-03-17 16:20:05	12	358	360	47	2049	7757	90	64.90	20	8.61	CHANGED	sphhshpslspWLp...sl..sh..tpYp-tFpppslss.phl..hphstccL...t.clGlpphscpp+llpplpphp	...................................hs.pplt.....p.W.Lp...........sl.........sl.....p....pYs.s......t....h.......p........p...p.......s.lsu.ph.l.........hph.s..p.p...p...L.................p..plu..l..ss.h.tp..Rp+lhpthpth.............................................	0	524	798	1345
+7476	PF07648	Kazal_2		Kazal-type serine protease inhibitor domain	Finn RD	anon	Manual	Domain	Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.	20.30	11.00	20.30	11.00	20.20	10.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.48	0.72	-4.02	73	4760	2012-10-02 00:52:43	2004-03-17 16:59:37	10	287	248	41	2600	6229	320	42.20	27	13.16	CHANGED	Cspppt..P..VC......GsDGp...oYss..tCthpstshpt...........ptp..hphhppss.C	................Cspt.....P.....VC..............G..s.D...Gp...........TYs...s.......tCth..pp.ts.stt.....................ttp.....hph.hh.s.C................................	0	733	989	1694
+7477	PF07649	C1_3		C1-like domain	Finn RD	anon	Context Domains	Domain	This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in Pfam:PF00130.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.89	0.72	-3.91	194	800	2012-10-02 13:15:50	2004-03-17 17:46:33	7	64	28	1	533	923	2	29.60	35	11.59	CHANGED	htCps.Cshshtt....shYt..C..h.pC.cFhl.HpsCs	......hCss..Cs..hshpt.........hYt....C..h.pC.cF.hl.HppCs.	0	367	463	489
+7478	PF07650	KH_2		KH domain	Finn RD	anon	Context_Domains 	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.58	0.72	-4.42	165	9989	2012-10-02 00:34:43	2004-03-17 17:57:18	12	35	5164	213	2428	7426	3812	76.60	27	28.69	CHANGED	cl.phlptpl.p.....tss.......huplpI..........ptshlsl+suc.GllIG+pGpplcplppplccpht.h.spp..............Vtlplh..cVccs.t	...........................................cl.phls..hcl...p............tss.............hupl.cI................ptshls....+..su+.Gl..VIGK..pGp..c...lcc..lt...pphcc.h.......spp..........................Vplplh..cV+ps.............................................................	0	805	1574	2054
+7479	PF07652	Flavi_DEAD		Flavivirus DEAD domain 	Finn RD	anon	Pfam-B_199 (release 3.0)	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.84	0.71	-4.45	19	6300	2012-10-05 12:31:09	2004-03-18 10:02:46	9	76	281	64	1	7229	89	121.90	49	4.66	CHANGED	h+KtplTlLDhHPGAGKTR+lLPpll+cslc+RLRTllLAPTRVVhuEMtEAL+GhslRapTsAl.sp+sGspIVDlMCHATaTpRhLp.Ps+hsNaplhIMDEAHFhDPuSIAARGalsopschscsAslaMTATPPGos-PFPcSNu	.......................................................................h......................................................................................................................................................................................................................sa.u...T.as..h.h...L...hs.....s.....s.....p..s..s.s.YslIIhDEsH....h..TDss.....S..I..huh.G.h.l...s..p..s.E.h.u.t..A.t.s.l.h.h..TAT.PPGSs.shPpup........................................	0	1	1	1
+7480	PF07651	ANTH		ANTH domain	Finn RD, Bateman A, McMahon H	anon	[1]	Domain	AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.\	   The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats [1,2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.80	0.70	-5.70	29	1195	2012-10-02 18:21:09	2004-03-18 10:47:20	11	20	303	13	707	1532	5	243.60	25	36.38	CHANGED	.sslphulhKATsp.p-sPsKc+asctIlhhops....tphsthhtslscRlspopsWslshKsLlllH+lLp-Gc.shhp-hhptppphsphtphps................shsaushlRpYstaLpc+lphatpttht...........hphttpt....................tp..tt........phsh.pll-pl.plQphl.phlphp.pssshp..spllltAhh.llp-shtlYptlschlhsLlp....phh-..hth.pscpshslhc+htpQhccLppFaphs+slthhps...IPpl.chssshlpsh-phhpps	............................t..ththslhKATst....ss.Kp.+ah.p.......l..h...h..h.s........pt..........h......p..h.......s....thh..sl.hcR..h.......s..t..s.....s....hl.........lsaKsLlshH+lh.p.c.......G....p...........p..hh.p..........ph.h...p..t.p.s..h..h..p...t..hst.....hsp......................................shshu..s...hlR....pYspaL..pp+.htha...pphsh...........................hph.cpt..................................................................tpss.t............phsh..pLLc.ph.hlQ.............p..l.s.hlp.h...p...t........ss.....ths....stsh.suhh.....l.hp-shplathhschlhsLh..p.............................phh-..h...................scphhtl.hc.+ahpphpcltc.Fhph..scp.l.t.....h.......pt....lPpL......p.....sPsshlps.-ph....t.......................................................................................................................................	0	180	352	538
+7481	PF07653	SH3_2		Variant SH3 domain	Finn RD	anon	Manual	Domain	SH3 (Src homology 3) domains are often indicative of a protein involved in  signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.60	0.72	-4.47	35	4617	2012-10-02 18:48:24	2004-03-18 11:11:45	12	450	402	69	2334	20355	74	59.20	23	7.44	CHANGED	hhpshpcass..s.ssss.................LshpcG-...llplh..........................tp..css.........sa.ahs.pp..s.......Gct......GhlPpshlp.h	..................................hpshhcass......p..ssst....................Lshp.c.G.D...............ll..p.lh...........................................pp...pss.............sa..WpG..ph.....s...................................G...ct.................G..h..hPsshlp......................................	0	522	751	1381
+7482	PF07654	C1-set		Immunoglobulin C1-set domain	Bateman A	anon	Bateman A	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.91	0.72	-3.98	128	16594	2012-10-03 02:52:13	2004-03-18 16:21:17	10	70	510	2328	2190	24856	1	82.80	38	31.24	CHANGED	s..pss.ph...sptshLsChVssFaP..sslpVpW.h+NGpplspsspsst.h..s....sDhoaphhotLphs...P.pps-..tYoCpVpHtuLp..psht	...............................................scpsoLtChs.h.G..F.Y.P....sc..I.s.l..oW............+.....s......G......c.........-......t.....o......p..c....s...p..h.....s..p......shs....s.............GDs...T..F..Q...p..hut..l.sls............s..sc..pp...pY.o...CcV..pHpuLs.pPl.s...................................	0	174	356	861
+7483	PF00008	EGF		EGF-like domain	Bateman A, Sonnhammer ELL	anon	Swissprot_feature_table	Domain	There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam).  The family is hard to model due to many similar but  different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. 	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.34	0.72	-3.96	71	24995	2012-10-03 09:47:55	2004-03-18 17:40:01	22	2546	284	90	15241	25121	202	32.00	40	10.56	CHANGED	Cspp....sCpst..GpChps.........ssapCpCs.G.....asGpp	................Ctss........PC.pNG....G..s..C...h..cts.......................ss..ap.CpC.ssG.......asG...................	1	6681	7484	11311
+7484	PF07655	Secretin_N_2		Secretin N-terminal domain	Yeats C	anon	Yeats C	Domain	This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggest that this family may be functionally analogous to Pfam:PF03958.	22.00	22.00	22.20	22.00	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.12	0.72	-3.60	60	476	2009-01-15 18:05:59	2004-03-19 11:19:25	8	5	427	0	107	379	37	91.00	28	16.70	CHANGED	TcTFslsYLthcRtGtSpToVsSGslSssss...sssssssssss.................sssssususSu....sussGopIpopscoDFWs-LcpslpullG.susGRtVlssPQA	.....................TcTaslsalphpp...pSto..olso......Gshossss........s................................................ssuusususou......susuusphpssscsDhasslcpslpshL..sstGphslsssp...........................	0	24	71	88
+7485	PF07443	HARP		HepA-related protein (HARP)	Vella Briffa B	anon	Pfam-B_21761 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues [1]. Family members may contain more than one copy of this region.	25.00	25.00	26.20	27.90	23.30	22.10	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.63	0.72	-4.59	15	154	2009-01-15 18:05:59	2004-04-01 10:52:49	8	9	78	0	90	142	0	54.50	44	11.43	CHANGED	FpVcl.GYppcLIAlFKslPS+sYDssT+pWsFuLcDYptLMcplpcL.spVsLcPL	.............FpVcl.GYst-LIulFKphPS+sY..Dsp..T+pWsFpLpDYstL.h..ptspsL..spVpLpPL............	0	18	25	53
+7487	PF07657	MNNL		N terminus of Notch ligand	Liu XH, He QY, Studholme DJ	anon	Liu XH	Family	This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins.	22.50	22.50	23.60	22.70	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-9.86	0.72	-4.05	24	383	2009-01-15 18:05:59	2004-04-06 17:22:07	8	106	95	0	183	325	1	75.10	44	9.34	CHANGED	uSGhFELclpsapNtpG...tsGpCCsGs.......stthshspCcTaFRVCLKHYQuplsssu...PCTaGsssTPVLGuNohslp	...........sSGhFELplp.phpNhpG.L.tsGpCCsus............ttt..s..stCcTaFRVCLK........cY.Q.u.p...Vospu..........................PCoaGsusTPVLGsNoFsl.........	0	35	54	113
+7489	PF07659	DUF1599		Domain of Unknown Function (DUF1599)	Yeats C	anon	Yeats C	Family	\N	25.00	25.00	26.60	28.10	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.02	0.72	-3.91	14	429	2009-01-15 18:05:59	2004-04-07 15:17:06	6	2	231	0	116	393	387	61.80	51	66.07	CHANGED	Kh+DYGsA....WRlhRlsSlTDQIaIKApRIRslpp.pupohVsEGIcuEaIulINYulhuLIQL	.......KsHDYGpA....W....R.........h....R...lo....SlTD.IhhKhpRl+pIE.....s..pGp.olV...s.E.GIcupahsllNYulhuLIpL.....	0	49	100	112
+7490	PF07660	STN		Secretin and TonB N terminus short domain	Yeats C	anon	Yeats C	Family	This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.20	0.72	-4.40	154	4169	2009-01-15 18:05:59	2004-04-07 17:23:43	9	51	1462	20	1089	3747	285	50.20	21	6.20	CHANGED	hslhhs.t..ptlps....ppsul...p.ss.h......slppuLpplLpssslphph.ssspl.hlttp	......................................phhhs.....stlpu...........tssul.......phss.h......shcpuLpplL.pu..s.GLshph..psshl.hlt...............	0	353	719	943
+7491	PF07661	MORN_2		MORN repeat variant	Yeats C	anon	Yeats C	Repeat	This family represents an apparent variant of the Pfam:PF02493 repeat (personal obs:C Yeats).	24.40	9.20	24.50	9.20	24.30	9.10	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.95	0.75	-7.19	0.75	-3.26	354	7333	2012-10-01 20:24:03	2004-04-08 11:38:36	8	45	575	0	1184	6471	5210	21.70	28	29.73	CHANGED	hpGhhptYapsGplppct.pacs	.............pG.hppYa.c.s.Gplppct.pYps............	0	627	928	1065
+7492	PF07662	Nucleos_tra2_C		Na+ dependent nucleoside transporter C-terminus	Bashton M, Bateman A, Yeats C	anon	Yeats C	Family	This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the C-terminus of this family of transporters.	25.30	25.30	27.20	27.10	25.10	24.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.29	0.70	-4.86	161	4136	2009-01-15 18:05:59	2004-04-08 14:27:54	8	11	1902	1	688	2281	695	208.40	39	50.08	CHANGED	aLluAShMuAPuuLlhAKllhPp.....ocp.sp.st........tpt..............................sNll-AhupGAhsGhplAlsVuAMLluFlALlAllNulL.uhl...G.........h............Gh............l............oLphILGalFuPlAallGV.P.a.sEshhAGullGpKlllNEFVAahsLs..phhss...............LSt+otsIloaALCGFANhoSluIhlGuluuls.PpR+sslAc.hGl+AlluGoLuslhSAsIAGlhl	...........................................................................YlluAsl..hsh.uulllupllsPhs.psppsh..........................................thtp..........cp............cspshh-hhup.ushsGh.........KlAlsVuAMLluFlAL.IAhlNull.u.sl.......sshh............Gh..............l..........................ohpt.....IlGYlFuPlA......alhG........l........P....h........s.......-A.hhuGolhupKLlhNEFVAhhsls..phhss...................................LSs+otuIlohhLsuFANFSSIGIllGulpu.ls.sc+s.st.lu+.hGl+hlhuuTLsslhSAsIAGlhl..........................	0	182	343	518
+7493	PF07663	EIIBC-GUT_C		Sorbitol phosphotransferase enzyme II C-terminus	TIGRFAMs, Griffiths-Jones SR, Yeats C	anon	Yeats C	Family	\N	25.00	25.00	41.50	41.50	18.90	18.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.03	0.72	-3.86	9	882	2009-01-15 18:05:59	2004-04-08 14:30:57	6	5	806	0	77	379	42	92.40	78	28.81	CHANGED	LSPlLGPGAVIAQVIGV.LIGsQIGtGsIPPphALPALFAINsQsGCDFVPVGLuLuEAKPETVclGVPAVLhSRhlTGsluVlIAWhhShhla	.......LSPhLGPGAVIAQVIGV.LIGVQIGhGNIPPpLALPALFAINAQAACDFIPVGLSLAEA+t-TVcVGVPSVLhSRFLTGsPsVLIAWhsShhlY............	0	24	39	62
+7494	PF07664	FeoB_C		Ferrous iron transport protein B C terminus	Bateman A, Yeats C	anon	Yeats C	Family	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N-terminus has been previously erroneously described as being ATP-binding [1]. Recent work shows that it is similar to eukaryotic G-proteins and that it is a GTPase [2]. 	26.40	26.40	26.70	26.70	25.60	26.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.74	0.72	-4.54	217	3526	2009-01-15 18:05:59	2004-04-08 14:37:58	7	16	2806	0	775	2731	228	54.20	34	7.91	CHANGED	llhulY.llGllsullsuhllp..pplhpup.sss...FlhELPsYRhPph.+slhhpsWp+	.......slhulY.llG..I.lh.All.suhlL+....pT.l...h+G..c....sss....FlMELPsY+lP....pl.+slhhpsWp+.............	0	304	565	683
+7496	PF07666	MpPF26		M penetrans paralogue family 26	Studholme DJ	anon	[1]	Family	These proteins include those ascribed to M penetrans paralogue family 26 in [1].	21.30	21.30	21.80	21.40	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.85	0.71	-4.25	11	22	2009-01-15 18:05:59	2004-04-13 10:35:31	6	1	12	0	13	21	3	104.00	25	67.62	CHANGED	hlphl+pl++luhhhllhahlssh.....llhlsllsalshhhp.p.hsp......s...h.hhhsllhlhlssl...hhIsphllpIlLhlKlsthKscpscapchphahhLhIlGIhl.slhulIssFhLs.KhpK	....................................................................t.hslGlL.Ihhssl...hhlhthILsIlhhlhsuphppcp.phtc..hphlLsIIGIll.slhslIsslhL............	0	11	12	12
+7497	PF07667	DUF1600		Protein of unknown function (DUF1600)	Studholme DJ	anon	BLAST clustering of M. penetrans proteome	Family	These proteins appear to be specific to Mycoplasma species.	25.00	25.00	48.60	48.60	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.78	0.71	-3.98	12	25	2009-01-15 18:05:59	2004-04-13 12:35:20	6	1	9	0	12	21	0	116.40	30	43.30	CHANGED	thhSslahHlhtPhh.Flhhhalhhshs.hhshpphhKhLlhshIYPhlYs.lYlhslPal...ahhtss..ssYoVYuhhTssp.s.hh...................uhslhhshhhlahslShlh.lhhphhthpchh	.....t.lhuslalHllsPls.FllsGalhhsas.tpsh+chtKaLlhshIYPhIYu.lYlholPal.................ahhssG...ssYSVYGhhTNsppNshh...................AhsllhshhFlaaPlSahl.lhhpahthpc+........	0	10	10	10
+7498	PF07668	MpPF1		M penetrans paralogue family 1	Studholme DJ	anon	[1]	Family	This family of paralogous proteins identified in Mycoplasma penetrans includes homologues of p35 [1]. 	20.30	20.30	20.30	20.30	20.20	19.80	hmmbuild  --amino -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.21	0.70	-5.26	30	71	2009-01-15 18:05:59	2004-04-13 12:59:48	6	3	5	0	55	69	0	290.00	34	77.48	CHANGED	TPcLKosVsLuGuLocIYDosss.....csTNsLIAc-IKsN.-sh..FsNGs-...hcslpshslTVcGsF....osSoW..sGpsYs.stps....W.........sshssssKllYsosusQlsIuSLsDLKopLsc.....psplKphLcsAssohss...sosaoV..pNpLGhT........s..sDLLHVNVpusp.......sssspNaDLQIPVSslNLplosLsloV......oGsNltsssctTTsFsYNIGI.cssssaspssssssssp.....s-sssusclLpcLGYss.t....................sssssLsNDplupuLGlYNspFo........t.tssssssssssspsYTlTLsAoP..spsYVW.DDG.oossKslSFsVslsls	..........TPplK.sslsLsGuLocIYDosss............csTN..pLIuc.-IKsN..psh..FsNGpc...hpslpshsloVsGsF....spS..sW.sG..t...s.Ys.s....W..............shsshsplhYsssusQls....IsSLsDLK.opLsp......tsplpphlptu.shshss...sssapl..p..NplGhT..........ssDLlHVNVtssp..........sssshshDLQIPsSslNLpls..sLploV......sGsN..ltt..s..sphoTsasaNIGI.csss...paspsss...tss.hsp.......sptssssplLtpLGass..t..........................ssshsLss-tlutuLGlYNspFo.............ssssspsssttYslolpAoP....spsYlW.-DG..osssK.ploFssplp..s...................	1	55	55	55
+7499	PF07669	Eco57I		Eco57I restriction-modification methylase	Studholme DJ	anon	BLAST	Domain	Homologues of the Escherichia coli Eco57I restriction-modification methylase are found in several phylogenetically diverse bacteria. The structure of TaqI has been solved [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.53	0.72	-3.68	29	913	2012-10-10 17:06:42	2004-04-13 13:56:19	6	28	738	0	199	3032	536	109.80	25	13.17	CHANGED	MK...FDVlIGNPPYQhss...tst..tss..............spPIYphFl-hAhclt...s+alshIhP.uRWh.tuGcshcpaRpphLpDp+lpplh.a.supclFssssIcGGlshhhh-.psp	............................................................................h....FDhlIGNPPYhct..p...p.......t..t...h.t.....htp................................................................tssslY...t.....h..F.h.-....t.....u.h..p..lhp........sGh.l.s.a....I..s..P...spah...pup...h..s...c.p.h.Rp.....h.l.l.p.c........s.p..l....pp.l.hp.h.s.s.........t.....p..........l.F...p...s....s..s..l...psslhhh.+t...t.............................................................	0	84	151	182
+7500	PF07670	Gate		Nucleoside recognition	Yeats C	anon	Yeats C	Domain	This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337) [1]. In the FeoB proteins (e.g.  Swiss:O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity [2]. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.36	0.72	-4.15	238	13008	2009-01-15 18:05:59	2004-04-13 14:15:06	9	26	3306	1	2612	8940	1060	117.90	18	34.76	CHANGED	hhphhshllhhhhllslLpph................................................Ghhshluphlssl.hp.l.Gh...sspssls.hlss....hhstpsulshhtphh..............................................................................t...hstpct.hshhh...hshh.hs..........shutl.s..shh...thhuhh	...........................................................................................................h.hphhshllhhhh...llslLpph..............................................................................................................................................................................................Ghhshlutlh.ssl.h.p.l..Gl......ssp..ss....ls...hlsu....h.h.s.s...t.s.s.ls.s.s.t.plh............................................................................................t.....hs...t...p...p...t...h...s...h...hh.......h.shh....hs.........shuhhs....hhh......h........................................................................................................................	0	936	1758	2209
+7501	PF07671	DUF1601		Protein of unknown function (DUF1601)	Yeats C	anon	Yeats C	Family	This repeat is found in a small number of proteins and is apparently limited to Coxiella and related species.	19.00	4.00	19.10	4.00	17.90	3.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.05	0.72	-7.52	0.72	-4.31	28	131	2009-09-12 22:43:26	2004-04-13 16:55:19	6	24	19	0	48	143	226	32.00	31	18.14	CHANGED	MGh+WpcLctQcLosRLLsAl+.....+Ns-pFNsQsIANTL	............................................LhpAlt..........ppspcFNsQpIANsL....	0	32	43	48
+7502	PF07672	MFS_Mycoplasma	MFS_Mycoplamsa; 	Mycoplasma MFS transporter	Studholme DJ	anon	BLAST clustering of Mycoplasma proteome	Family	These proteins share some similarity with members of the Major Facilitator Superfamily  (MFS).	20.80	20.80	20.90	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.03	0.70	-5.22	7	58	2012-10-03 03:33:39	2004-04-13 18:09:49	8	1	45	0	19	92	2	252.00	30	55.53	CHANGED	p+pKohlSshNhaGFNlGhhlshs.Flhs.slppsuops..WhhIhoshILllhshLllahhFtpch..hhsp..KQoK.p.shssc......sohhslLKpKpTaKhhshaGlhLlslV.shTsshhN.l.ls.SP...hsl.............................suGhhhhshshhhIhaVhGahhGhhsloPFNKThacRK+althhhshshlhlllhllh.uhhlGhssshGhsh......hhIhoFluGsFhWulQushLhlPaEhKthp.scVulhFGhlWGhGYlhYThhDIhhSshhp	.................................+pKullSphs.ahaslGsllsllP.F..lhs...ps..s..p..thpss..Wphlhslhu.LLshIPLllahlh..GpcFDhhtsp....ppst....p.t.ts...........hslhshLKpKsTatWlllYGuWL...llsV.a..sho.s..hh...p.h...thSs....................................ssphs.thhpha..Ih.Fl.h.uhhlG..hslGhas+hphcR+halsh....hhshGllhh...ll...uhlh....sh.thGhs...ps.uhth....................hhIhuF..LsGhhh....WGIQuVhL.lPHEYKss.sPpplGhhFulIWGhGYhhaTlshIllSsh....................................	1	11	16	17
+7503	PF07673	DUF1602		Protein of unknown function (DUF1602)	Studholme DJ	anon	Clustering of A. pernix proteome	Family	\N	24.20	24.20	25.10	24.70	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.70	0.72	-4.49	43	115	2009-01-15 18:05:59	2004-04-13 18:16:47	9	3	81	0	21	116	7218	37.50	42	17.33	CHANGED	GSStsphtG.hssARAhATRCCpPP-SssGhhhut.u...spP	......GSStshhtGthspARAhATRCphPP-sshGhhhtt.u..pP............	0	5	12	17
+7505	PF07675	Cleaved_Adhesin		Cleaved Adhesin Domain	Yeats C, Collyer C	anon	Yeats C	Domain	This is a family of bacterial protein modules thought to function in various roles including cell adhesion, cell lysis and carbohydrate binding [1].  The beta-sandwich jelly-roll topology of these modules is known as the galactose-binding domain-like superfamily, clan CL0202. A tandem repeat of these modules (either two or three repeats) constitute the haemagglutinin/adhesin (HA) regions of the gingipains, RgpA, Swiss:Q51816 and Kgp, Swiss:P72194 and Swiss:P72197 [3] expressed by Porphyromonas gingivalis (Bacteroides gingivalis) [2].  They form components of the major extracellular virulence complex RgpA-Kgp - a mixture of proteinases and adhesin domains [4]. The adhesin domains in this complex are found in proteinase-cleaved forms when isolated from the cell surface [5].  Haemagglutinin genes of P. gingivalis [6] (hagA1 HAGA1_PORGI - Swiss:P59915 - and hagA2 HAGA2_PORGI - Swiss:Q51845) suggest that such proteins are composed of eight to ten tandem repeats of these adhesin modules [1]. Genomic data predicts that homologous protein modules are also expressed by a number of other bacteria and form part of putative multi-domain proteins, eg. Swiss:Q26BR9 and Swiss:B0VGL6. These domains may be acting in concert with other adhesion modules thought to be part of these multi-domain proteins such as fibronectin type III, Pfam:PF00041, and Meprin, A5, mu (MAM), Pfam:PF00629, domains.	20.50	7.00	20.80	7.10	20.10	6.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.25	0.71	-4.66	9	203	2012-10-03 19:46:52	2004-04-14 13:37:02	6	31	36	6	40	218	69	157.90	28	23.51	CHANGED	stlL.EuFEsG.lPsuWpsIDADGDGtsWtphsssh.......hsGHsustCshStSa.lshhGs...LTPDNYLITPcl....pGut+lpYWVssQD.ssasuEHYAVhsSoTGssAuDFs.lLaEET....hTuKs.............pGsWhpRTlsLPAGTK...YlAFRHasCTDha..alhLDDVsl	.................................................................h....Es.p..p.s...h.s.stWphI.......Duc.u........D..u.p.sWhhhs..s.s...........................hsu+su.st.s.sh.S.h....u...h...s.h..tt.......hs.s.DN..aLI..oPpl.....sG.s.p..p...lpaass...s...ps....t..s..a.s...s...EcY....s...VhhS.s..T...G..s........ss..usFs...hlh--s....hssts..............tusWhppolsL...P.sGT+....YlA.aR..H..h.s.s..o..D....h...h...h.l.hlDDlp.....................................................................	0	29	40	40
+7506	PF07676	PD40		WD40-like Beta Propeller Repeat	Yeats C, Mistry J, Adindla S	anon	Yeats C	Repeat	This family appears to be related to the Pfam:PF00400 repeat This This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].	20.60	10.90	20.60	10.90	20.50	10.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.99	0.72	-4.23	127	15082	2012-10-05 17:30:43	2004-04-15 11:18:12	7	349	2793	58	5424	14558	9482	34.90	24	15.47	CHANGED	hpplssssu............stsPsaSPDGpplhFsSscs......Gs.p.....lah	.................................................h........t...............................ptsP.saSP.DGppls....aso.p.ps..........u....................................	3	2058	3763	4721
+7507	PF07677	A2M_recep	A2M2; 	A-macroglobulin receptor	Studholme DJ	anon	Prosite	Domain	This family includes the receptor domain region of the alpha-2-macroglobulin family.	21.70	21.70	22.00	21.70	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.86	0.72	-3.80	92	1246	2009-01-15 18:05:59	2004-04-16 09:26:22	9	72	186	60	533	1171	2	88.00	30	6.72	CHANGED	osMsll-lslhSGFtsspssLcpLppstphh....lp+hEh.....psspVllYh-plsppp.hClsFphpp.phtVuth.pPAsVpVYDYYps....sppssphY	.................................SsMull-lslhSGFhsspsslp.pLp..p.s.sphh........+hEh......psspVllYh....-...pls.pp.p............pslsh.pspp.phtVut.h..pPAsVplYDYYp.s....pcpssthY.............	1	90	147	332
+7508	PF07678	A2M_comp	A2M3; 	A-macroglobulin complement component	Studholme DJ, Sammut SJ	anon	Prosite	Domain	This family includes the complement components region of the alpha-2-macroglobulin family.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.86	0.70	-5.14	43	1721	2012-10-03 02:33:51	2004-04-16 09:40:48	9	109	288	67	626	1697	23	213.90	31	19.09	CHANGED	pGYp..RpLsYK.+sDG..SYSsF......pst....suSTWLTAFVlKsFu............pA+pa..IhlDppplppulpWLlpp.Qpss.GsFppsu.lhpptMpG..Gl.........-scloLTAalsIALhEst...........hsps..............................psuls+AhthL.cst......ssshspsYshAlsAYAhsLss.cpsptpphhppLcppAhpc............................sss...haWppsppsp..sptt..................ssuhpVEhTAYsLLs.hlst...........p-lshAptIlpWLspQpNstGGFpSTQDTVVALpALocYut	.......................................................................................................GYp..ppLpa+....+t..D.........G...Sausa.....tpt................suSs....W..LTAaVh.+.s.ht............tApph....h..l...-....phl.ppuhpWLhpp..Qp.s.s..G.pF.p.....-...sG...l.h.pp..sh..pG..Gh.......................................ppsluLTua...lllALhE.st....................hsph.....................................psslp+u.hpaL.ppp.........htph.pssYs.h....Al...su.YA..htLs...pp.......tt....pthh.p.pLt..th.u..hpp............................ss........haWtpst................................hplE.hTuYsL..Lu.hl.t...........pcht.tu.....lhpWLspQp.p...G..GFs..S.....T.Q...D..T..hluLpALspa..h....................................................................................................................................................	0	122	188	400
+7509	PF07679	I-set		Immunoglobulin I-set domain	Bateman A	anon	Bateman A	Domain	\N	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.92	0.72	-4.13	48	59728	2012-10-03 02:52:13	2004-04-20 17:44:00	11	3030	1617	375	30033	71682	78	88.50	21	29.33	CHANGED	PpFsph..pshplptGpssphpCplpGs.PsPplsWh+s..sp.lps............spchplptps......sptoLpIpssphsDsGpYsCpApNp.sGpspssspLpV	.................................................................................ps..h..p...s....h....t....G...p.....s...s...p...l...p....C........p.......s.......p..........G...........p.......P.....t...........P..........p.........l........p.......W..h..+s.........s.p........l..p.s.....................................................s.p...c...h..p....l..p.t.ps........................t..p.L...p...I....p.....s......s......p......h......p......D.......s.......G...p...Y...p.C..h....A....p....Nt....h..G...p..s...p.t.p.h.tl...................................................	0	6694	9324	18688
+7510	PF07680	DoxA		TQO small subunit DoxA	Kletzin A, Studholme DJ	anon	[1]	Family	Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation.  A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Swiss:Q8AAF0.	20.70	20.70	20.70	23.90	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.55	0.71	-4.53	9	80	2009-01-15 18:05:59	2004-04-20 18:14:37	6	2	72	0	25	79	2	135.30	31	48.50	CHANGED	hhassllGsLhNhSKhPclc.lshhphpsss....LhhplsclsGPDsYsuhlshlplhsusucllLppss......clsphPhsphKs-Ylshhu..........ulhlsLGucAplpLplP..hcLs..GTYplKLassu..Gtssttthpa	...................................hp.tshGsLpNhShtPthp.lus...t.hpsss....LphplaRspGsDsYGuFlltlpLhs.s.s.Gcl.lhphsu.....ppLuplPtssIcNcY.s.s+.hs......sutaulhlPLGucATlplp.hs......hpls.pGs.YpLpLhDlu..Gtsapt....h.....	0	8	17	22
+7511	PF07681	DoxX		DoxX	Studholme DJ	anon	BLAST	Family	These proteins appear to have some sequence similarity with Pfam:PF04173 but their function is unknown [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.74	0.72	-3.56	103	6635	2012-10-02 13:32:46	2004-04-21 11:57:59	7	10	2739	0	1741	5119	2239	87.30	23	51.92	CHANGED	ulLlhRlhluhlFl.hpGhpKlh..................shsu..........ssthhs....shsl..................sshhuhhushsElsuulhlllGlhTR....huAhhlsshhlsAh....hhsHt	..................................................hhlhRlhlu....h.l....F....l....htG.h.t.Klh.............................shss.........................................ht.t.hht..................sh.u.l.................................................ss.h...h....s....h...l.s...s....h...sEls.uGl.hll...l.......G.......h.......h..TR.......h.u..A.h....h..hs.h.h.h.l.ssh.....hhh........................................................	0	475	1065	1446
+7512	PF07682	SOR		Sulphur oxygenase reductase	Kletzin A, Studholme DJ	anon	[4]	Family	The sulphur oxygenase/reductase (SOR) of the thermo-acidophilic archaeon Acidianus ambivalens is an unusual enzyme consisting of 24 identical subunits arranged in a perfectly symmetrical hollow sphere and containing a mononuclear non-heme iron centre (personal communication: A. Kletzin). At 85 degrees C in vitro, elemental sulphur is oxidised to sulphite, thiosulphate and hydrogen sulphide with no external cofactors needed. The proposed equation is:  4S + O2 + 4 H2O ---> 2 HSO3- + 2 H2S + 2 H+.	25.00	25.00	191.60	191.40	22.80	16.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-12.12	0.70	-5.83	3	21	2012-10-02 00:20:33	2004-04-21 13:41:55	6	1	16	25	7	26	2	295.40	54	97.85	CHANGED	PKPYVAINMA-V+N-PKThELFupVGPKVCMVTARHPGFVGFQNHVQIGVlPLGsRFGGAKM-MocEhc.............oLcLhQYThWKcWKDHEEMH+QNWupLFRLCluCAoQMVWGPaEPIYEI+YANMPlNTEMTDFTsVVGKKFApGc..sluIPsISQPYGKRVVAFGEHpVKEGhEcQFEEuAIKTLEhF++.APGFLGuMILKEIGVSPlGSFQlsuKGFHQlLESsGul-PcsssTI...YpsPEF+....s+PpcYIVHsEWScs-ALMFGhGRVLlsPElRcVHD.KVLDTLlY.GPYIRVlNPlMEGTaWRE	.....hlAlN.sclhNt.pohphh.pVGPKVCMVTApHPGFVGFQNHlQlGllPhGsRYGGAKMDMscE.s.............sltlhQYThWKDWKDHEEMH+QNauhlFRLChSChuphl.GPWEPlYEIlhAsMPhNs-MTDFsuslGccFApGc..PhslPsIS.PYGpRVVAhuEHoVhPG+EKpFE-uIl+TLEhhK+.APGFLGhMlLKcIGVSuIGShQhsscGhHQlL..EosGuh.Pcssssh....aps..PEA+.....sTPppYlVHhEWuss-uhhFGhGRVllpPElRplHD.cVL-TLlh.GPYIRlhNPMMEsThWRE.	0	3	5	7
+7513	PF07683	CobW_C		Cobalamin synthesis protein cobW C-terminal domain	Bateman A	anon	Pfam-B_1247 (release 5.4)	Domain	This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis [1] and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.18	0.72	-4.27	158	5707	2009-10-26 17:34:02	2004-04-27 12:18:52	9	25	2706	1	1476	4245	1150	96.90	22	27.04	CHANGED	lpohshptcpshc.....ppltphlpp.......hs........ts..llRsKGhltls....sp.st.hhhhptlsthhpht.ht..hts.............................ts+psclVhI...Gp..sl-...pptlpptLpssl	.....................................................pohshp.t.ctshc.....pph..p.hlpp................hs......................................ss...llRhK.Ghl..h.ls.................sp...s....p...hh...hhp........tstt.h.hphp.....h....s..........hts..............................................................tstpsclVhI.........Gp....sl-....pst....lpptlpt..................................................................................	0	401	896	1201
+7514	PF07684	NODP	NOD; NOD1; 	NOTCH protein	Guo J, Studholme DJ	anon	Guo J	Family	NOTCH  signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be  elucidated.	21.90	21.90	27.00	23.80	21.40	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.10	0.72	-4.37	28	312	2009-01-15 18:05:59	2004-04-27 13:03:59	7	249	96	8	140	249	0	61.70	36	3.09	CHANGED	cltGolVaLElDNRpC...ppsscC.FpsAssAAsaLuAhusp.psLph.saPIpsVpups.psssss	............hGSlVaLEIDNRpC.............psuspC.FpsssssAsaLuAhAup.ssLp...sYPl.sVtucs.ts....s..............	0	26	38	81
+7515	PF07685	GATase_3		CobB/CobQ-like glutamine amidotransferase domain	Bateman A	anon	[1]	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.64	88	5307	2012-10-03 00:28:14	2004-04-28 09:26:43	9	29	2967	0	1396	9246	3546	155.60	25	37.14	CHANGED	ssph.s.ssDhlllPGo+ssht-Lthhc.ppuhccslpphhppGt..llGICGGaQhLGcplt.....ct.....shss...hpGLGlLshpTthpp.pKtlspspspsht..........pshtlpGaEhHhGpohh.sst..hhhh...............tsthc.....ushs...psslhGTYlHGhatsssh	....................................s.....s.ssD.h.lh.l.sG..u....p...s......p...h......p......s......h......t.....h......tc......tp...s......h.p...p...s.l..p...p...t....h...p.....p......G...t......s..llulCG.G.aQ.hL.Gcp..lt...............................sss.u....hp.G.lGlL.s.h.p.T..t..........h...p........s.....p+t..lu.thpsphtt..................................stslpG.......a.......E...hH...h.Gpohhsss.st.shhth...................................................pttsth-.........Gsh..........ss.lhGoYhHGhh.sp..................................................................................................................	1	449	934	1202
+7516	PF07686	V-set		Immunoglobulin V-set domain	Bateman A	anon	Bateman A	Domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.70	0.71	-4.19	113	19537	2012-10-03 02:52:13	2004-04-28 13:40:02	12	592	276	695	9493	120210	5	107.80	17	38.44	CHANGED	s..lpp..sp................................hpst.GpslpLpCphp...........t...tltWh+..pps........spt.phhh.........ht....thttpapsphph.tsss............ttphsLplps.lphsDsGsYhCshhs...............hhhhspsspLpV	....................................................................................................t....................................h.s.t.G.p..s.l.p...LsCphs...........................sth...t.l..t.W..hp......pps................................sp..s.....phlh...............................t..t...t.t....t..t...h....s...s.....p.....h..p..s..R.h.p...h......t.s.ts.....................................tt..s.h..s.L.p.l.ps..l.p.h..p...D.s.G..h.Y...hCth.t.....................................................................................	0	892	1878	3948
+7518	PF07688	KaiA		KaiA domain	Bateman A	anon	Bateman A	Domain	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. The overall fold of the KaiA monomer is that of a four-helix bundle, which forms a dimer in the known structure [1].	30.00	30.00	47.90	47.70	27.20	26.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.84	0.70	-5.12	3	66	2009-01-15 18:05:59	2004-04-28 17:16:04	7	1	65	14	22	79	31	249.20	44	92.72	CHANGED	LoIClaV.SsAIuQ-LpRlaouDRapLssFpSt--FCsYLEs+R-pIDCLILhaussShp.VlspLaapGsLLPAILltPpsS..AcPs-Psss.lYHsAElHLspcQL-QLPpQVDcAIAcFL+LuPlCTlPsHlhhh.ssLh-uSsps.LlsQQRRLAQKLKERLGYLGVYYKRDPu+FaRNhSPtEKQKLL--LpSpYREIVLSYFSs-usVN-pIDpFVNpAFFADluVSQVLEIHMELMDEFSK+LKLEGRSEDILLDYRLTLIDVIAHLCEMYRRSIPRE	..............................................................................h.hh.s.tl.p.htp.hL.s.p+Y.......l.......hp.s.pp..hhthlptppcplDslll..p......hhppLhppuhllPs.ll.l.t...........................................tsph.......YHssElpl..pplpplth.lDtAIspFLphu..ssthsp...ps................t.pt.........l.hpQpRLup+L+ERLGYLGVYYKR...........sPppFhRsLsssE+pcLLcpLcpsYRcIlLsYFss-tslNptIDpFVNpAFFuDlsVopllEIHMELhDEFSpQLKLEGRS--hLLDYRLsLIDllAHLCEMYRRSIP+....	0	2	14	20
+7519	PF07689	KaiB		KaiB domain	Bateman A	anon	Bateman A	Domain	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and is found to be a dimer [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.60	0.72	-4.51	16	352	2012-10-03 14:45:55	2004-04-28 17:24:08	7	6	163	18	129	572	244	80.00	41	45.47	CHANGED	hLaVuscshsptpshpslpplppcphshpapLpllDltcQPpLsEtc+llATPsLlKlhPtPhphlsGs...pphhhhh.ch	....................+LaVuG.possShpAlpsLcp.lh-..p..c.h.t..s...Y.sLcV..I..DlhcpPpLAE.pccIlATPT.L.l.K.l.h.P.sPl+.+.IIGDLSspc+VLhsLc.h........................	0	31	86	113
+7520	PF07690	MFS_1		Major Facilitator Superfamily	Bateman A	anon	Pfam-B_5 (Release 13.0)	Family	\N	32.60	32.60	32.60	32.60	32.50	32.50	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.78	0.70	-5.74	195	181668	2012-10-03 03:33:39	2004-04-30 10:30:46	11	489	5747	5	55719	183465	25371	295.20	13	82.52	CHANGED	lhhsthhshhshth.............hhshh.......s..hh..............tpp..........................................hs........................................hs.st.....huh....lhsh...hhl..sh...slsthhh.Ghl..s-....+.h.....G..p+p.hhhhuhlhhulu..hhhh.......h.......ss......hh.h......lhhhph...ltGhst.uhhhssshshlsphhst.p.....cputsh..uhhts...shslGs.hlG.shluu....hls.thhu............aphs....Fhlhuhlslls...hl..h..hhh..............................htptstttttttttt...........................................h.hshht.........hthhhpp.........h......................hhhshhhh.....hhshhs....hhhhhsh......h.........tpthuhs.....................hhss..hslsshhshhh...thhhuhls.c+.......hst......thhhhhshhhhhhsshshhhhshs....................hhhhh...........shhl....hGh.uhuhh....hsshhshssphh....s..........pttu.....pshuhhs.hhts.lusslus	................................................................................................................................................................h.....hh..h.h.s....h.................h...s..hh..................s............hh.................................................hp.p...................................................................................h..s..................................................................................h.s.....s.t..............................h..u.h......................hhs.h..................h.hl........sh....................sl...s...t......h.........h.......h...G....h..l..........s..-...............................+..h...................G..............p..+......t.....h........h.....h.....h........u.....h....h...h......hs...ls.........hhhs.......h..............s................ss....................................................hh....h................hh..h...h...th................l.h..G......h..........u.......t........u............s........h.............h........s..........s.............s........h......s...........h.....l...........s...........p......h......h.....s....t....p...........................p..p....u.......t........s......h.........u......h.....h..t..s....................s.....h...s....l......u.........s.....h........l......u.......s..........h....l....u...u.....................h..l....h....p...h...h.u............................................................a..p...h.s......................a..h...........l......h......u..s.......l....s.l.l..s..................hl..........h.........h.hh............................................................................h..............t...........................................................................................................................................................................................................................................................................h...h...t.............................................................................................hhhhh..hh..........................................h.h.h......................................h....h.h.s..................................................................h...t.hs.................................................................................................h....h................................h.........h...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................................................................................................................................	0	15082	30526	45126
+7521	PF07691	PA14		PA14 domain	Rigden DJ, Mello LV, Galperin MY	anon	Rigden DJ, Mello LV, Galperin MY	Domain	This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.49	0.71	-4.55	34	1994	2012-10-02 01:24:23	2004-04-30 11:44:52	7	314	720	31	924	2134	500	135.80	15	13.85	CHANGED	tpsGl.tthahpssth.s...h.................pss..sshh.stthss.shs.sphssphsGhlpsspsGpYpF..tlt......uDssscla......lsuphll-ps...stp.......................phppslthhuuphYsl+l-ahptsssthh........pltWsssssstpshstss	.........................................................................t........................................................................................................t.................................t..h...t............s.....p..a..s.h......c..hp....Gh.l.p...s.....s.p....s....G.......p......Y....p..........F..tht..........u-s..s..s...c.la.................l..s.........s...p....h..l....l-p.t............stpt.......................................................t...pt..p.ss.......l..t...l...p.sG......p..ha..tl..clpahp.ttstt...................h.h.............s..............................................................................................	0	402	643	808
+7522	PF07687	M20_dimer	Peptidase_M20; 	Peptidase dimerisation domain	Bateman A, Studholme DJ	anon	Pfam-B_253 (release 4.0)	Domain	This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases [1]. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [2]. Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.27	0.71	-4.33	178	25350	2009-09-11 20:10:22	2004-04-30 16:35:36	9	57	4852	83	6606	19881	6380	112.40	18	27.08	CHANGED	hup+Ghhshclp..........spGpsuHuu.hsthshN..Alp.......hhschlspLppp.................................................................sohplstlpuGt....stN....slPspspsphshR...h.stps..hcplhpplpphlppthhptp	.....................................................................................................s.ht..h..plp..........lp.G..p..s..u..H..uu...h..P..p...........t......u...h.s.....Alt...............hh.s....ph...l..s....p....l..p..s.h.....p.h...................................................................................................h.........s...s....l...s...l...s..p..l..p.u.Gs....................shN..........ll...Ps...psph.p..hslR.......sh..s..t...p.s.....hc.....tlh...p.plpphhpt.....th..........................................................................................................	1	1986	4003	5480
+7523	PF07692	Fea1	HCR1;	Low iron-inducible periplasmic protein	Merchant S, Studholme DJ	anon	Pfam-B_60541 (release 13.0)	Family	In Chlamydomonas reinhardtii, the gene encoding Swiss:Q9LD42 is induced by iron deficiency [1].  In green algae, this protein is periplasmic. The two paralogues FEA1 and FEA2 are the major proteins secreted by iron-deficient Chlamydomonas reinhardtii, and both are up-regulated in response to iron deficiency. FEA1 but not FEA2 is up-regulated by high CO2 concentration. Both FEA1 and FEA2 are secreted into the periplasmic space and genetic evidence confirms that their association with the cell is required for growth in low iron [2].	25.00	25.00	27.30	26.60	24.20	20.30	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.24	0.70	-5.63	3	23	2009-01-15 18:05:59	2004-05-04 12:51:18	6	7	9	0	20	23	61	329.40	25	55.92	CHANGED	SVLhLVlAAGAlslAsAQ.sTTGsthGGFpaAGNVIGYVNMThDYCDIQAALuAGDFTEALsIYssGKNSp+GsAp....psFh+FAoYh-ANtoGpsFaDAl.................LhsS-TahsDshlGAA.GDGD..........ATlAtGVIsVuTLKYthHEhDoAluKp....ADGNu......uDASGAPHNlDEAWAhaaGGssusCGshSuWtaS....LstAh..pGpsahGuSsuNThMlpoFlNuhcAotosuThpIpuhsAARsNphRlLsLpuLp..ushtYT-cAtsuYsccsupsshupphIAVsWshhc.MLphpsasGuuVN..slthlDFhhcpTEupLSSp...AVcsALKsVlpsLGh-sA-l..GulcucIhD-ohshcCuucTshulp	....................................................hh..............s..t..t..hs.hsGap.sosVltasphshDht-hp..A..u...lput.s.assAhphYopGtNShpupup......cThps.huoaspu..phsuEshaDsh...........................hhGp.sshhtshh.tAs.usts........................h..tslKtuhhpsshh.YshHEl--Alscs......tssss.......usssGuPHshDEuWAFYsGShp...Gssusuo.u.tth.............lstth......ttssh..sGs.o....s..ssshhhs.hpt.h..us..h.psst...th.....spspsshspllthhslshlQ..uhl..+..YthtAssu.tpsuspttt..t.....W.sa.t..shL...h...p...s.....ustst........cl.pt.s..t.uht......tlcttlcslhSshGhphupl..Gs........................hsss.shh............................	0	16	19	20
+7524	PF07693	KAP_NTPase		KAP family P-loop domain	Aravind L	anon	Aravind L	Domain	The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side [1].	20.00	18.00	20.00	18.00	19.90	17.90	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.87	0.70	-5.44	22	1164	2012-10-05 12:31:09	2004-05-14 10:44:01	9	77	813	0	383	1481	411	290.10	15	42.16	CHANGED	hs.hupplschlspss............tsshslulpGtWGsGKophlphlppthppp................................................................................................................tphhlsphssahhsst.cshhtth...hsslhpsltpchpt.ttphhhthp...........hhshhhthththhhtsshhhhh.h...............................................................................pp.ppphpthhpchtppLcp.......ptclllllD-LDRh..cspphhpllcsl+hlhph...pshsalLshDpchl...tpulpptht........supcal-Kllphshplsssshpp.lcphhtpt...hpshhpthsppth.................................................................shphshhhss.s.ts.hsPRpl+Rhlsslphhhthh	.........................................................................................................................................................t.h.p.hlt.p...............t.sh.slu..l.u..tWGsGKo.h.l.p...h...h.t..pp.h....ppt.......................................................................................................................................................................................................................................................................................................................p.hhhh....hss.h.....t......p....t........p...p...hh.th.......ht....p..l.....h........p..t..h..t..t..t........t.....................h.h..h...........................................................................h...............h...h...............................................................................................................................................................................................................................................................................................................................t.....................t...p.h.p......................h......ht...p..h...p...l.pt...................p.tlllhlDp...LD......ph.......t......p...hhphh.ph...lc.h.hhsh...................h..hh...lhs..h..c.p..l.................tsltt..t..........................s...........tahpphhph...h.l.............t......h.....................................................................................................................................................................................................................................................................h.............................................................................................................................................................................................................................................................................	2	116	190	297
+7525	PF07694	5TM-5TMR_LYT		5TMR of 5TMR-LYT	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type) [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.03	0.71	-4.92	106	2704	2012-10-03 02:46:00	2004-05-14 13:35:26	7	88	1472	0	397	1873	31	168.50	27	32.17	CHANGED	s.hFcpl.h.ppph.phtp.clhlhllFuhhuIhusahGlpl.................................s..ulsNsRslslhluGlhGGPllGlhsGlluGlaRhh..lGG..hsuhssuluolltGlluGlltthhpp......phhshhhuhhhuhhsEhhp...........hhlll......lhspPhstuhpl.......lphIulPMllsNslGsslhhhllpsh	....................................h..hFh.l.h.p.ph...ph.p.+.hh.l..hllFol.h.s.l.hu.s..a..h....Gl...lc........................s....uls.Ns...Rhl..slhhuGl.lGGP.hVG.hhs.Gll....u.G.l.a..R.ah........hGG........hs..u.l.s....s..h.....I..o..o........I..l.hG....l.l.u..G.h...l.thhhhp................chhs.hhhu...h...hl...s...h.l.sE..hlp............................Mll.l..l...................hhup...s.h.t....p...u.l.pl.............l.phI......u.h..PM...h...lss.o.lusulhhhll...p...........................................................................	0	119	232	308
+7526	PF07695	7TMR-DISM_7TM		7TM diverse intracellular signalling	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) [1].	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.86	0.71	-4.65	179	1345	2009-01-15 18:05:59	2004-05-14 13:37:09	6	102	600	0	524	1395	170	202.00	15	27.75	CHANGED	pph.hhuh.hhGhlls.hhlYNLhlahth.+-psalaYshal..hshhlhhh....s..hsGhshpal....hs......s.hhtphhhhhhhhlsh.hhsh.Fspp.a....Lph.p.t........plhphhhhhhhh..hhhhh................hh.....hthhhhhhh.....hhshlhhlhhhhhulhth..hcshpsA+aal..luahhhhlushl...hh.h........hhu..llshs.hhs..hshtl...Ghhl....chllhohALu.....+	.....................................................h..hh.uhhhGhhhh.hslas..lhlahhh..+c...p...sa...l.aauhhs..hshh.l.hhh.......s....hpG..hh..ht...hh........s...ths....h....t..p.thh....hh..hhh....hshh.hhhl..Fhtp.h.....lphpp.t............thhph.h.h.h.hh...hh..h..h.lhhlh.........................h.s.hh.........hs.hhh..hhht.............hhhhl.hh..hhhhh.hshhth......hcs..h...........ps.A..t..h.h...l.....luhh..h.hhl.s.slh.....th.hh..........hhu........hls.s.....hh....s.....hhh.h......uhhl....thlhhuhslu........................................................	0	178	351	447
+7527	PF07696	7TMR-DISMED2		7TMR-DISM extracellular 2	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins [1]. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives [1].	21.30	21.30	22.00	22.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.46	0.71	-4.75	114	945	2009-01-15 18:05:59	2004-05-14 13:41:02	6	52	497	4	371	965	86	135.70	17	17.93	CHANGED	hsl..s.tthphhcDsssphslspl..t.....t.pspFpsh........psphs.hGhspusaWl+hsL...tsssstpt.......phlLplshshL-p..lclYh......tss......thh.hhptGcp..hsasp.Rthtppshlasls.L..sssps.hshalRlpS.psshphP......lplhss	.....................................h......hphht.D.ssphs.l.spl..........ps.tapth......................psphs.huh.....s.p..s.s.....hWl+hsl.........tss.ss.p.ph.....................p.hlLpls..h...sh.lc.p..lsl...ah......tss...................s.h.p.hhphGsp...hs....hsp...Rt...ht.t....p....s...hla..ls..l........sssps..hshhl+lpo.p.t....hp.hs......l.lhp.....................................................	0	115	220	299
+7528	PF07697	7TMR-HDED		7TM-HD extracellular	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the extracellular domain of the 7TM-HD (7TM Receptors with HD hydrolase) [1].	22.60	22.60	22.80	22.70	22.40	22.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.20	0.70	-4.61	62	847	2009-01-15 18:05:59	2004-05-14 13:44:56	6	5	814	0	235	690	293	217.30	18	31.07	CHANGED	LpsGplA.hsIhAP+slp..DptsT-p++ppAtspl...VYshctp..hspphhpp.lpphh....splpplp...ppspt..................................................pcltph.hss...............ls-pthpp...........................................................................hh.ptsppphpphc......sslhpsl...schhs.........pslss..sthtpttp.....cs.ptpl.phtsh...sss....hptssphlsphh.lpsNhhhDtptTpphppcshpplpslh..lcpGplIV+cG-hlopcthchLchlGLlpp	...............................................................................................................................................hplu.psIhushph.......s.p...t.Tcpc+ptAtptl...s.Yt.hppp..htpp.hpt.l.p.pha.......t..l..pphp....pp.pt............................................................................tplhph.h................hh.p...lspp.htp................................................................................................................................................lh.ph...stp..php.thp...................sthhph.l..............sphhp.............................ptlpp......pphtphpp................................ch.tppl...p..sl...sst......hpp.hhpt.l..hp.h..ltsNhhhDpptTcpt+p...pshpsV..pssh..lhpGplIVccG-hlspcthphLchlthhp.p.....................................................................	0	107	187	219
+7529	PF07698	7TM-7TMR_HD		7TM receptor with intracellular HD hydrolase	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	These bacterial 7TM receptor proteins have an intracellular Pfam:PF01966.  This entry corresponds to the 7 helix transmembrane domain.  These proteins also contain an N-terminal extracellular domain.	27.50	27.50	27.60	27.60	27.20	27.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.27	0.71	-4.86	99	879	2012-10-03 04:04:29	2004-05-14 13:47:25	6	4	869	0	252	722	397	193.80	20	27.36	CHANGED	hhshlGhhlhlhlhhhhhhhahc+h.p.plhppp..ptlhhh...hlhllhlhLsph...lhh.hs.............hsalhPlsssshLlshhlssclul.....hhsslhullhuhh..........shshthhlhtlluuhsushhlp.+hppRsplhtuulhlulssh.hhhhsltl..lpsss.............h.....t..plhhpshhshhsullsu...llshGllPhhEshFsllT	............................................h...hhGhhl.hlhlhlhhhhh.ahcp.....h...p...p....phhpcp....t..lh..hh.h..hlhhlslllhph.......hhh.hp.....................hsallPhAhsslllpl.hls.p.+hul.....hs.sl.lhslhsuhh.h........shsh.phhlhtlluuhsush.hl+.c........h........ppR.sp.lhtuuh.hlulhss..lhhhslhl......lpsss......................h....s...phhhphhhuhh.sullus....llshGllPhhEphFslho............	0	121	201	235
+7530	PF07699	GCC2_GCC3		GCC2 and GCC3	He QY, Liu XH, Studholme DJ	anon	He QY, Liu XH	Family	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.24	0.72	-4.38	41	2150	2009-09-13 19:08:02	2004-05-14 13:53:13	8	312	132	0	1375	1889	98	47.60	31	7.28	CHANGED	Gpahs.....sst.....t.CpsCPtGoY.......p...spsups...pChtCPss....psT.ht..Gupshs-C	.....................G.a.t......sst........ptCt...sCPhGoY........p......sptGps......pCh.sCPss.....stT...pt...tGupshppC.....................	0	558	661	1027
+7531	PF07700	HNOB		Heme NO binding	Iyer LM, Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	The HNOB (Heme NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to  histidine. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce  diverse downstream signals, in both bacteria and animals.	21.10	21.10	21.10	21.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.91	0.71	-4.73	16	853	2012-10-02 19:02:47	2004-05-14 13:56:09	10	23	422	52	440	781	58	159.00	24	32.10	CHANGED	MaGhlhpslpchlpcpaGp-VW-plhcpsuh-.ppsapstp.YsDshhhcLlssluplhshshcplhchaGchhlpahhcpGaschltshucshpsFlpslDs.lHhplsphY..Pph+sPuFpspst.scssllLcYpSpR.GhhchllGll+slA+pFtp..-lplphlcppp-	..........................................MhGhl.pth.t.hl.p.p.a.G..ph.hpp.h.........hpps....t..hp......t.t..a....sht.Y.....s-.p.....hhplltsh....u.p..h.h..s.....lsh....pp..lhchaG.chhh..ph...htppt..c.hl.......psh..Gsshp-FLp.....................slDs.l.....H.p.plp..ph..a.....ss...hc......sPsFpspph...sp....s............sl..h.lcY...h...S..p..R......shtths..h..............GllcusAcphhp..clplphht....p..................................	0	159	223	352
+7532	PF07701	HNOBA		Heme NO binding associated	Iyer LM, Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	The HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce  diverse downstream signals, in both bacteria and animals.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.35	0.70	-5.13	33	958	2009-09-11 06:19:49	2004-05-14 13:58:40	9	50	126	16	637	851	5	138.40	30	19.84	CHANGED	shspchplsspsFCcsFPFHllascchplhQhGpulp+lh.........sphhhspp.......pls-hFcllRPp.lphoFcsIls+lNolFllpo.....+t............p.sp.t....p...........................................................................................................................LcLKGQMlalsEsssllFLsSPhVssL--LpppGLYlSDIPlHDAoRDllLluEQtcAphpLppchE..phpcpLcpshptL-pEKc+T-cLLYullPtsVApcL	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tlh..............pphp.......phpspL....c.......cp....p....p....tLcpE.K+KT-pLLaphlPtsVAppL.......................	0	228	292	501
+7533	PF07702	UTRA		UTRA domain	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to Pfam:PF04345 [1]. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules [1].	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.38	0.71	-4.58	168	12427	2012-10-01 19:33:20	2004-05-14 14:00:43	8	13	3138	54	2128	7191	599	138.40	19	57.50	CHANGED	spGtp.spsc....llphphhsu..sspluptLsl.sssst.VhclpRlRhh...-spPlsl-psalstp.hhssht.....pp.ph......ppS..laphLcp..hsh...tlsp..uppplp.Aths.sscpuphLsl...sss..sslL..hlc+hsasps..upsl-aspshapu-cac	......................................................Ghpspop..llp.hph.h.....s....s..t..plup...t...L...s.....l...p.....s.p...p......l..h.pl.p..Rl..Rhh..........-s...p....P....h..h....l.......-..ps..al...s.....h...p...h..h..s..s..ls...........pp..th............ppS...l..a.ph.lcp....hsh...pls.p......up.p...p...lp..sh...h.s....ss.....c.....u.p....h....L..p.l......sts....p.P..lL...hlc.ph.s...a...s..p.s....upsl-aspshaps-ta...............................................	0	564	1212	1689
+7534	PF07703	A2M_N_2		Alpha-2-macroglobulin family N-terminal region	Studholme DJ	anon	Prosite	Family	This family includes a region of the alpha-2-macroglobulin family.	21.50	21.50	21.50	21.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.86	0.71	-4.37	184	2785	2009-01-15 18:05:59	2004-05-14 15:54:42	9	133	1371	58	856	2463	101	141.90	22	9.28	CHANGED	lpl...phsc..pshpsG-shplplp..sshs................up.hhhhl.h.pspllptt............................................................thp.hpssps.......................................slplslspchsP.sshlssh.hl.............................................s....hshsss.hlsVpp.sp...phplplps.s....p.phpPspphplplp..s.....................suhlslsAVDpulLtL	.....................................................................................................................................................plthsp.sthpsG-s..hplplpsshs................sp.hhhhl....s.ps.pll.h.hp............................................................................hhc...ls..spth...............................................................slplsls.p..s..h..sP..shhls..sh..hl............................................h...sphshssh.tl.slp..s...sh...ph.s.l.p.lps..s.............s..ph....pPs....p.p........ls..lclp.s.................s.suhlsl.suVDpulL.l.............................	0	194	349	599
+7535	PF07704	PSK_trans_fac		Rv0623-like transcription factor	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the Rv0623-like (Swiss:P96913) family of transcription factors associated with the PSK operon [1].	28.30	28.30	28.50	28.40	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.61	0.72	-3.30	29	347	2012-10-02 18:44:02	2004-05-17 11:25:38	6	1	139	0	81	156	29	81.60	36	96.75	CHANGED	Mu.LsIKsscscpLA+clAchTGp.ohTpAlppAlcccLp......ccppptshh..-cltsl.....hpttthshhss.psscpphhaDEhshss	.........Mu..LsIKsscscpLsccLA.tcsGp.ohTpAVtsAl...pcc.Lu...........ttppcpssLt..-cLtsl.....hcptuhssscs.ttscphh...hYD-pGLPt...............................	0	20	42	63
+7536	PF07705	CARDB	DUF1604; APHP; 	CARDB	He QY, Liu XH, Studholme DJ	anon	He QY, Liu XH	Domain	Cell adhesion related domain found in bacteria.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.20	0.72	-3.96	72	1259	2012-10-03 16:25:20	2004-05-17 11:57:42	6	225	338	5	749	1464	732	105.20	19	17.15	CHANGED	tP...DLhl.........thssssshsspp.slss.s.lpNpGsss.usshplp.........lYlsus.h...sshsl...........suLsuGsspslshshhs....ps........Gshs.lpsslDssNtlsE.sN...EsNNphot	...................................sDLhl.........t.hhssss..s..t.s.G..p.s..hsl..ss...s..V.pN..p.G.....s.ss.....u..s..s.....h.p....l.p........................l..h...l...s.ssts..................sstsl................................ssL...s.s.G..p.......o.....t......s.....l....s..hshsss............ss....................................G.s.ap..lt..s...h.s...D.s.......t....s.........t......l.......E....s.....c..sNN....s........................................................................	0	244	406	657
+7537	PF07706	TAT_ubiq		Aminotransferase ubiquitination site	Hargrove J, Studholme DJ	anon	Pfam-B_15367 (release 13.0)	Motif	This segment contains a probable site of ubiquitination that ensures rapid  degradation of tyrosine aminotransferase in rats.  The half life of the enzyme  in vivo is about  2-4 hours. In addition, unpublished information identifies at least 2 phosphorylation  sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at  S*QEECDK. This region of TAT is probably primarily related to regulatory events.   Most other transaminases are much more stable and are not phosphorylated.	18.90	18.90	18.90	22.20	18.40	17.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.31	0.72	-7.87	0.72	-4.02	7	51	2009-01-15 18:05:59	2004-05-24 12:14:22	7	3	35	0	25	44	0	41.20	55	9.12	CHANGED	hcsYlIQMsususL.......PolLDsHVNlsGhsoV........uKhKuRKsR	.MDsYVIQMsusGsL.......PSlLDVHVNluGRSSV.......sGKhKGRKAR..	0	1	1	7
+7538	PF07707	BACK		BTB And C-terminal Kelch	Stogios PJ, Studholme DJ, Finn RD	anon	Stogios PJ	Domain	This domain is found associated with Pfam:PF00651 and Pfam:PF01344 [1]. The BACK domain is found juxtaposed to the BTB domain; they are  separated by as little as two residues [1].  This family appears to be closely related to the BTB domain (Finn RD, personal observation).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.15	0.72	-4.18	81	5713	2012-10-02 01:20:04	2004-05-27 16:12:29	10	234	772	7	3017	5073	29	98.70	24	18.96	CHANGED	ClulhpaA-ta.sspcLhphuppaltppFhpVhps-.-Fhp.LshcplhpllssDcLslpsEcpVapAlhpWlpa-hppRppthsclL.ppVRl.sLlsspaLhphlp	......................................Clthhthu.c.ha....st.p.cLt..p.tshp.....a..l...hpp.F...p....l......h.....p.......s....-......-..........F....hp....L...s....h....ppl...h..p.l...Ls..p.-p......L.....p..l........p.....s......E.....pp.............l.ac..Asl...p.W.........l....p..............t..........c..............h...........p..........p............R.........p.........p.........h...........h........s.............p.............l....l....pt..lRh..shls.thLhp...............................................	0	922	1157	1963
+7539	PF07708	Tash_PEST		Tash protein PEST motif	Yeats C	anon	Yeats C	Motif	This motif is found in the Tash AT-hook proteins of Theileria annulata. These proteins are transported to the hosts nucleus and are likely to be involved in pathogenesis [1]. It is also often found in conjunction with Pfam:PF04385. It is suggested that they may be 'part of PEST motifs' (a signal for rapid proteolytic degradation) in [2],  though this is not definite. This motif is also found in other T. annulata proteins, which have no other known domains in (unpublished data: C Yeats).	22.40	22.40	22.40	22.40	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.33	0.73	-6.32	0.73	-3.83	11	113	2009-01-15 18:05:59	2004-05-28 10:38:50	6	10	2	0	52	114	0	18.70	62	4.55	CHANGED	E-L-PETIplElpSD-E-p	...pLcPETIPVEluSDEE-...	0	0	47	47
+7540	PF07709	SRR		Seven Residue Repeat	Yeats C	anon	Yeats C	Repeat	Associated with Pfam:PF02969 in  This repeat is found in some Plasmodium and Theileria proteins.	19.50	2.30	19.70	2.90	18.70	-999999.99	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-6.43	0.77	-6.36	0.77	-2.75	14	54	2009-09-16 13:37:02	2004-05-28 11:45:45	6	9	8	0	38	51	9	13.60	30	9.06	CHANGED	pphccVcssYppLp	..ppacpVpssYpplp...	0	12	31	34
+7541	PF07710	P53_tetramer		P53 tetramerisation motif	Bateman A	anon	Pfam-B_782 (release 3.0)	Motif	\N	20.70	20.70	20.90	21.10	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.89	0.72	-4.86	28	335	2009-09-11 15:49:44	2004-06-01 14:29:59	6	11	99	129	105	383	0	42.20	46	9.30	CHANGED	KK++s....tDcEhFTLplRGREpYEhLpKlp-uLELt-hh.sppps	.............K++s............D-E.h.....ahL..plRGREp...aEhLhKlpEuLELh-hl.sppp.h........	1	12	18	42
+7542	PF07711	RabGGT_insert		Rab geranylgeranyl transferase alpha-subunit, insert domain 	Finn RD, Bateman A	anon	Pfam-B_20675 (release 13.0) 	Domain	Rab geranylgeranyl transferase (RabGGT) catalyses the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking [1].  This domain is inserted between Pfam:PF01239 repeats.  This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP [1].	21.10	21.10	21.40	22.30	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.45	0.72	-4.19	4	58	2009-01-15 18:05:59	2004-06-02 17:26:25	6	16	37	3	24	51	0	98.50	59	19.56	CHANGED	-hIpCVaVSR-EupVoVuFS+PVts..tpssLlLhLDspP.tVpWRoscsR.++S.lWlCDLPssuIsDpsspHshpVhWT-tcs++-CsLYsGppEsWCRDSA	.............-uLRCLHVSR-EACLoVuFSRPllVu.sts-sLLLhVD-SPLhVEWRTPDGRNRPS.HV..WLCDLPAuSLNDphPQH.oFpVlWTuu-spKECVLhpGRpEuWCRDS....................	0	2	4	10
+7543	PF07712	SURNod19		Stress up-regulated Nod 19	Studholme DJ	anon	Pfam-B032880 release 13.0	Domain	\N	25.00	25.00	27.90	29.40	21.30	23.20	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.28	0.70	-6.02	3	106	2009-01-15 18:05:59	2004-06-03 14:42:03	7	3	29	0	66	84	1	309.50	44	88.67	CHANGED	FLKTEc+IKSAVFaSPKlELuPGSVSN+aYYDIDFPRGHIuLKuFsAEVVDEAG+PIPLHETYLHHWlVVRYHQsKsScpsppphF....................IaVRNuGlCQusoLGQYFGLGSETRGTuTYIPDPYGIEIGNPEEIP-GYEEKWLlNIHAIDTRGVEDKpGCIECKCDLYNVTlDEYGRuIRPsYKGGLhCCYDpTQCKLKcGF.pGPK.RSLYLKYTV+WVDWDcYllPVKIYIFDVTDTLKlSD+SKGsss-HsCKlEYEVEPCsTNshpcsGCVDVKKsSLPMQsGGYVIYGVAHQHSGGIGSTLYGQDGRVICoSIPKYGNGcEAGNEsGYIVGMSTCYP.PGSVKIhDGETLTLESNYSNslcHTGVMGLFYlLVAEQLP.Pcl	................................................................................................................................................................lpotsFhSsth.hsPGplss+hhhslcFP+GHlulKuFsuElV..D...p..tG..s....slPLaETYLHHWhh.t..Ya...h...s......p.....................t...h......................hhh+NpGhCptthl.pa.aGhGuEoRtTso.lPsPaulEhGNPtths..p.GY-E+WllNlhsIDTRG.s...D+..huChEC+C.......D..............h.......YNV.ThD..............sp..............lp....................sY+GGLhCC.DthpCph.pp...GF......pu....p....Rplh.L+YslpWl-Ws.p.h..lPl.+..lYIhDsT...Dp.......ps.p................psCp.......hEYp...l..t.sssst....s..s.csppsp.hsh..................pGG..................llYGsuH.HsG........shsuoLaG.p.................DG.RhlC.....sShP......pYG.....sG.pEuGNEtGYlVGMSsCYPp...PG...ol.+ltcGEhLsl.opYss.p..t.pTGVMGhFYlhlA-......t.................	0	7	58	64
+7544	PF07713	DUF1604		Protein of unknown function (DUF1604)	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of several eukaryotic RNA processing proteins (e.g Swiss:Q8N3B7).	25.00	25.00	25.30	25.30	20.00	19.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-9.96	0.72	-4.19	20	248	2009-01-15 18:05:59	2004-06-03 14:42:41	8	7	214	0	185	248	1	86.30	55	10.82	CHANGED	pchlPlacQpVpDEcGR.+RFHGAFTGGFSAGYaNTVGSKEG....WsPpTFpSSRppRus....sp..sppsEDFMDEEDlu-ht.tspplpoppcF..s	............p.p.lPlhcQpV+DEcGR.+RFHGAFTGGFSAG.........YFNTVGSKEG...............WTPoTFsSSRpsRAc............pp......pp+PEDFMDEEDluEht...ts+plpTsspF............	0	70	105	150
+7545	PF07714	Pkinase_Tyr		Protein tyrosine kinase	Studhome DJ	anon	Unknown	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.54	0.70	-5.32	145	24806	2012-10-02 22:05:25	2004-06-11 14:25:16	12	1823	1048	846	13827	124495	4199	232.30	26	33.84	CHANGED	lpht.cpLGpGsFGpVacGphp...................ttsphpVAVKsL..+...p..sssppt...hpcFlp.EuplMppl.pH.plVpLhGlss...........ptpP.....hhllhEahptG...sLhsaL+pp..................................................................................................ptplshtp.LlphuhQlApGMpYLps+p..hlHRDLAARNlLls.....c.............st.hlKIuDFGLuRtl.........pps.Y..ptpssuc..hPl+Wh...APEulptsp..........aospSDVWSFGVlLWElhohGp.pP..............Yssh.ssp-........lhphl.cpGhR..hsp.PptCPsclY.pl.MtpCWptcPppRPoFppl...hptL	...............................................................................................................................................................................................................................p.lG..p....G....t.F..G....t...V..h..t...u....h.................................................t.h........V.......A.......l.........K..........h..........l.........p...................t....................t...t............t............t..........t................................................p...........p...................F.........h.................p...........E.................h...........p...........h..............h.................p.............p................l................p...................H.............................N...............l...............l...............p...................l............h.................G.....h....sh.................pt.t.......................................h.h..l...l......h........E........a........h........t....t....G.................s...L....t......p......a......L....p...p..p.......................................................................................................................................................................................................................................................t..t.........l....s.....h.....t....p.......h....l........p.....h.....s.......h....p.........l...........A..........p..........G....h........t...........Y..........L.........c.................p.................p..........p...................h...........l.............H...............R................D.........L..............t...........u..............p...........N...........l......L......l...s....p........................................................sh....h....s.....K......l......u.......D.......F.....G.........l...u......+..h...........................................t....t......h...................h....t......t.......t...........s........h.........h.............s........h................t...............a......h..................A.....P.........E........h....h.........t..t.h.........................................h....o.....t......p......o.........D.....V.........a.................S..............F.............G...............l....l.........l..........h......E..........l.............h......o..................s.....t........P.....................................................a............t........h......p.......t.....t....p...........................h....h.....t........h........l..........p..........p.........s............h........p....................h...................h...........s................................t...........s...........s.............................t..............h..........h.............p........l..........h..............h........t.......C.............h.......p.............p..s...p...p...R.P..s.htplht.......................................................................................................................................................................	1	4020	7259	10608
+7546	PF07715	Plug		TonB-dependent Receptor Plug Domain	Yeats C	anon	Yeats C	Domain	The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.23	0.72	-3.72	742	36469	2012-10-03 10:59:06	2004-06-15 15:23:27	10	123	2367	66	9642	33866	11001	109.70	22	13.45	CHANGED	shpssstulss......lstcp.lppp..s.sssls-sLp......t..hP......Glsh.........................sssssss...s.....s..sh...........slRGh.....ss....................spshlhlD.Gh.h..............................tts...........shs..t..l.s.....s.....t..sl-plEVl+.Gssos.lYGs.suhGGl	...................................................................................................t...phstslss.....l.s.t.c..p...l.ppp....s...ss..s...l...s..-..s.Lp...................t...hP...........Glsh.................................ssss.sss....s...........s....pl.................plR...Gh.....ss...................................sps.hlhlD...G.l.h...............................................tts.................shs....t..l.....s........s.......s..sl.-..p.l-Vl+..G...s.s..u.s..lY.G.s...s.uhuGs............................................	0	3204	6758	8441
+7547	PF07716	bZIP_2		Basic region leucine zipper	Studholme DJ	anon	PfamB-200; Release 14.0;	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.57	0.72	-4.14	48	1966	2012-10-02 13:17:30	2004-06-16 18:28:29	10	24	376	25	1196	6475	28	53.70	29	17.49	CHANGED	pssphpp+Rc.+NNtAu++SR-+++t+ppphpp+ltpLpccNppL...cpclppLcpE	.................pphtt+.R....c..+N.s...A..A++SR-+++...h+p..p.......p...l.......p...p.......c.......l....tp.......Lp...p-.Np.pL..........cpclttLpt..........................................	0	353	569	934
+7548	PF07717	OB_NTP_bind	DUF1605;	Oligonucleotide/oligosaccharide-binding (OB)-fold	Yeats C	anon	Yeats C	Domain	This family is found towards the C-terminus of the DEAD-box helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. There do seem to be a couple of instances where it occurs by itself - e.g. Swiss:Q84VZ2. The structure PDB:3i4u adopts an OB-fold. helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins [1].	21.40	21.40	21.50	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.61	0.71	-4.25	118	5209	2012-10-03 20:18:03	2004-06-21 13:22:17	11	143	2032	5	2747	4906	191	134.10	22	12.53	CHANGED	pQLtplh...................................................pch...phph..........p.........................................................pp.phl+pslsuGha.plA.....................................thp............pp.....sp..Ypsh................................tpsp.hlhlHP.uSs...l...........hppps.c.....................allapEllp.............T........s+..ah+s........................sotl.pspWLhth.u...sph	...........................................................................................................................................t.QL.thh.................................tphth...p.....................................................................................................................................sshptl+pulhu.Gh.hs.plu...................................................php...........................pp...tp...Yhss.............................................csp....phhlHP..u..Ss.....L..........................hcp..t.P.c....................................................a..llatElVp.......................T..............................o+...ha..h..R.s.............................sstl..cPpWl..l..usp.......................................................................	0	873	1456	2200
+7549	PF07718	Coatamer_beta_C	DUF1606; 	Coatomer beta C-terminal region	Yeats C	anon	Yeats C	Domain	This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). This C-terminal domain probably adapts the function of the N-terminal Pfam:PF01602 domain. 	25.00	25.00	36.20	30.30	23.60	22.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.55	0.71	-4.53	25	351	2012-10-03 16:25:20	2004-06-21 13:22:31	7	9	301	0	255	354	8	138.40	49	15.21	CHANGED	QsDDhIsF+QLpu+putsssp...sh-sDLs+AT.G.sssspp.chs...p.....+Ls+VhQLTGFSDPVYAEAYVsV+QYDIlLDVLlVNpTs-TLQNLolELATlGDLKLVERPpshTLuPtsFpsI+AsIKVSSTETGVIFGsIVY-ssu	..................................................................QsDDsIsFtQLstcssh..s..stc.............thp.sLtt.Ah.G......ssppp.p.shs..............SKLs+.V..sQLTGFSDPVYAEAYVpVpQaDI................VLDVLlVNQTs-TLQNlolEhAT.LGD..LK.lVE+P.....s.shs.LuP+-Ftslc.................AslKVoST-sGVIFGNIVYDsss...........	0	90	147	213
+7550	PF07719	TPR_2		Tetratricopeptide repeat	Studholme DJ	anon	Context matches from Pfam 14.0	Repeat	This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by Pfam:PF00515.	27.00	13.00	27.00	13.00	26.90	12.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.73	0.74	-7.75	0.74	-3.60	369	18395	2012-10-11 20:01:00	2004-06-21 18:10:22	12	4257	3733	24	7965	120483	33152	32.50	19	6.62	CHANGED	spshhthutshhptsch.pcAhptapcAlplssss	.........................hhhthGt.h.h.h..p.t..s..c...h..p...cAhp...h.appAlpht..................	0	3026	4971	6601
+7551	PF07720	TPR_3		Tetratricopeptide repeat	Studholme DJ	anon	[1]	Repeat	This Pfam entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones [1].	20.70	11.00	20.70	11.00	20.60	10.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.19	0.72	-7.60	0.72	-4.11	18	1102	2012-10-11 20:01:00	2004-06-22 13:19:31	7	26	538	52	97	1589	293	33.40	29	26.08	CHANGED	h-hlauh...AtshatptcappAhph....hhshlptps	................h-hlhua.............Ahshpp.p.tchpcAtsh..at..hhhhhsh.s..............	0	34	50	73
+7552	PF07721	TPR_4		Tetratricopeptide repeat	Studholme DJ	anon	Manual	Repeat	This Pfam entry includes tetratricopeptide-like repeats not detected by the Pfam:PF00515, Pfam:PF07719 and Pfam:PF07720 models.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.82	0.74	-7.35	0.74	-2.96	143	472	2012-10-11 20:01:00	2004-06-22 16:56:25	9	256	297	0	244	3990	1150	25.00	25	5.32	CHANGED	ststhshApshhttGchspAtshlcp	..........hhhsLAtshhtpGchspApphhc..........	0	84	180	210
+7553	PF07722	Peptidase_C26		Peptidase C26	Studholme DJ	anon	MEROPS	Domain	These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C terminus [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.30	0.70	-4.90	45	3232	2012-10-03 00:28:14	2004-06-23 11:09:18	8	15	2292	12	825	18376	10620	205.10	31	78.01	CHANGED	PlIGlsusht..htttshtshst.pYltuth.pulptAGGlPlllPht..sspshpphlstlDGllloGGt.sVcPphYutpsp.tpss.hsssRDthclsLlctAlppshPlLGICRGhQhlNVAlGGoLaQclpt....t..thht........p......htssHslplp........uohLuplh.....s..sc...hpVNShH+Qulcc........LussLpVpApus.DGllEAlps.stp.hFslGVQWHPE	................................................................................................llG.lss.s.............................................t.......t....h.........pa.ls..tthhphl.t.t.u..GG.l.Pl...l...l..........P.......h........s.................s...........p.......h.......h....p.....p...hl...p..h..l..D..GllL...sG...Gt.sV....p...P..p...h...Y........G.................p..p..................................t........................p................t........s................s......h.....s.......t........R.......Dth...-...l.s.L...l.c...t....A...l.c...p.......p.......hP...lh..uICRG.hQ..l...........l...N........V.....A.......h...G...G..o..L...a..Q..c....lp..p...........t......h.....t...p.hp.p.......................................p.................hs..s..H.p...l...p.l.p..............................................ts...o...h...L.t..p.lh.......................................s....pp.....h.h.V..N...S...h..H..+...Q..u..l..c.p.........................l.u..s..s..L...c...l...p...A...h............u..........s......D.....G......l......l......E...A.....l.....p.....s.......h....s.....t....t......hhl.GVQWHPE....................................................................................................................	0	299	509	675
+7554	PF07723	LRR_2		Leucine Rich Repeat	Studholme DJ	anon	PfamB-152 (release 14.0)	Repeat	This Pfam entry includes some LRRs that fail to be detected with the Pfam:PF00560 model.	20.90	9.50	20.90	9.60	20.80	9.40	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.64	0.73	-7.26	0.73	-3.24	161	389	2012-10-02 21:32:02	2004-06-23 16:09:48	8	33	40	0	269	479	1	25.70	36	6.48	CHANGED	sLKsLpL.pp...lta....ssctslppLlSuCP	...........sLKoLpL.pp...Vpa.......ssctslppLlSuCP........	0	142	155	160
+7555	PF07724	AAA_2		AAA domain (Cdc48 subfamily)	Studholme DJ	anon	PfamB-40 (Release 14.0)	Domain	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.94	0.71	-4.35	139	20963	2012-10-05 12:31:09	2004-06-23 17:05:00	9	82	5116	83	4876	26856	10382	171.50	36	26.68	CHANGED	cPhushlhhGPTGsGKTp.........Lu+sLAphLh..............spppshhphDMSEahE........c+slu+LlGussGYVGh-puG.Lo-tl....tppPasllLlDEIEKAcs...............sV.phLLQll-suplo.........-spG.ppVch+NsllIhToNhuupthtp........................................hpt.h.t.lpthahP.EFlsRls.h	.........................................................................................................................................hushl.hlGPTG..s.G.KTc...........................LAc.sL.AchLh....................................................................................................................................t.tpsh..hp..h.......D..h....o....E.ahE...................................c....p...s.......l.......s.....+...L...l...G...u.......s.........s.....G.......h......V.......u...h.......-..c...sG...................................................tllllDE..I-...Kups........................................s....V........p......h.LL...p.ll...-....s....u...p..lo.........................................................................D.sp.G....hpV...D..h.....c..N....s..l.h.I.h.Tu.N..huutp..h.p....h...........................................................................................................t.t...hp.ts...p.....l.p....h.h.....h.....P.........EFlsRls............................................................................................................................................................	2	1633	3130	4111
+7556	PF07726	AAA_3		ATPase family associated with various cellular activities (AAA)	Studholme DJ	anon	PfamB-40 (Release 14.0)	Family	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.70	0.71	-4.54	55	4128	2012-10-05 12:31:09	2004-06-24 10:26:01	6	8	2112	1	1431	6260	2158	130.60	58	39.23	CHANGED	HlLlEGVPGluKThls+sLApslshsFpRIQ.FTPDLLPuDlhGo.plactcs....ppFcFctGPlFusllLADEINRAPPKTQSALLEAMpE.+QVTlsGpTasLPcPFhVlATQNPlEpEGTYPLPEAQLDRFlh	....................................................................................HlLLEsVPGluKThh...s+...sL...A....p.s...l.....s.......h.............s..............F...p....R....I...Q....F.....T...P.....D..L.........L...P...u........D.....l....s..G........s......p......l....a...s..t..ps...................t.p..F......c......F........c..........G....P.......l......F............s........N...........l...........l.....L..A.........DEINR.....A.....s....P.....K....T.....Q.....S...A...L...L...E..A..M.....p.....E..+.....Q.....V......T.....l......s.....G....p.....T.....a.....s...L...P.....p.....P...F.....h.V...l.A.T.Q.N.P..l.......E.......p.......E........G.T.Y......P.LPEA..QLDRFlh.....................................................................................	0	512	1017	1260
+7557	PF07727	RVT_2		Reverse transcriptase (RNA-dependent DNA polymerase)	Studholme DJ, Eddy SR	anon	PfamB-40 (Release 14.0)	Family	A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses. This Pfam entry includes reverse transcriptases not recognised by the Pfam:PF00078 model.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.61	0.70	-5.41	99	7027	2012-10-02 12:54:00	2004-06-24 14:06:22	9	498	350	0	1834	6948	486	136.70	27	23.93	CHANGED	NpTWcLVshPpsp.+slGsKWVF+hKhsscG.slpRaKARLVA+GasQppGlDYp..ETFuPVs+hsolRhlLulAuppsaplcQhDV+oAFLpG-LcE-..lYMpQP.GF.spsp......sspVC+LcKuLYGLKQAPRtWap+hsshLhphGFpputsDssla..h+ppsssh.lhlllYVDDlllsusspphlpphKppLspcFcM+DLGthpaaLGlElp+..sspGlhLoQppYspcl.LpchsMpss+..PssoPhsss	........................................................................................................................................................................................................................................................................s.salp..u.....l...p..-..p....l..ah.....t.......P..uh.................................t..hh.h..h.L.......+u.lYG......L+.Q.......u.s....t....W.....p.h...t..t.h.h.....t....th..s......p........s.h....a....h..............t....t................h..hl.hl......aVDD.h...........................................................................................................................................................................................................................................................................................................	1	611	910	1250
+7558	PF07728	AAA_5		AAA domain (dynein-related subfamily)	Studholme DJ	anon	PfamB-136 (Release 14.0)	Domain	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.54	0.71	-4.45	34	10563	2012-10-05 12:31:09	2004-06-29 09:05:52	9	237	3591	15	4659	65399	18925	134.50	18	14.25	CHANGED	sllLlGsPGsuKohlsppluttl.....spshhhl.hspshots-lhtthph.......ssttthhsuslhpAsp..........cuplshl-Els+sp.sslhssLhslLsc+phhh.pssthhtst...........................hpllusuNshs.......hthsphssALtpRF	..................................................................lhlhG....sGs....GKo...t.....l...s..c......t..l....u..thh............................st..........h......h....h.......l..............h.......s........t..........t..........h.......s................p......c....l.........h...G...t...h....s...............................t..p..h..t....h...p....s...u.......l...h..p..s.hp...................................................................................ps..h....l....l....h....l..D.E.l..........s...........h.............s.............t.....s..........p..............h..........h.......s......s..........L......s....l....l.......c....p....p....p.....h....h....h.......t...t.....s....t......h...t..h.................................................................................................hhl..l.s.s.h.N.sht..................h..t..uhhpR......................................................................................................................................................	1	1765	2764	3880
+7559	PF07729	FCD		FCD domain	Bateman A	anon	Pfam-B_117 (release 14.0)	Domain	This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain Pfam:PF00392. This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical [1]. This family has been named as FCD for (FadR C-terminal Domain).	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.55	0.71	-3.80	317	20783	2012-10-01 22:11:53	2004-06-29 14:06:45	7	44	3128	16	5347	14681	1573	125.20	20	52.31	CHANGED	-...l...h...ph...RthLE.....stss.p..hAs..pphss...........pplpplpphh.......pphppshp.....tsch.t.............hhphctpFHttlhptusNthlt...........p..hhppltttht.h..hhthth................stpphppshpc..Hp.pllcAlts.pDsctAtph........hppH.lpt	........................................................................plh.ph...RthlE......stss...p....hAA....tp..t.os.........................pp.l.t.p..l.pphh.............p.p...h..p..p..s.hp...........................ttc.htt...............................................hhp..h.-..hpFHt.tlh.p.s.ut..N..h.Lh................p...hh.p.p.l.hshhp..t.......hhthhht............................ptpt.h.p.p...h..hpp......Hp.tIlcA.l..t.p.p.D.s...c.t..A.pps...........hppHlt.t....................................................	0	1367	3132	4302
+7560	PF07730	HisKA_3		Histidine kinase	Studholme DJ	anon	BLAST	Domain	This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.27	0.72	-3.63	191	12598	2012-10-11 19:05:54	2004-06-29 14:17:48	8	320	3309	15	3406	10118	555	67.60	26	14.71	CHANGED	ERpRIARELHDsluppLsslthphphhpthh.....ppsst...........psppplpplpphsppuls-lRplltsLR..sssh	.............................ERpRlARELHDslup..pLssl.p.hp.h...p..h.hpphh.......ppsst.............................psp.ptlpplpphsppuh...pcl.RplltsLR.s.....................................................	0	1258	2513	3067
+7561	PF07731	Cu-oxidase_2		Multicopper oxidase	Studholme DJ	anon	PfamB-49 (Release 14.0)	Domain	This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.81	0.71	-4.67	127	6906	2012-10-02 17:41:00	2004-06-29 16:37:37	9	88	2541	150	2712	7112	437	134.00	20	24.40	CHANGED	ths.pssshhph................................t...hhssspshslphsshlclhh.s........s.............................sHPhHLHGasFhllspssssh............................sh.ssspRDTltlss....suhssltaps...D.NPGsWhhHCHlt..hHhstGhhhhhh.tsts	.........................................................................................................................th....................................................t.t....h.sstph..h..t.l..p....h....s...p...h.h.c.h..h..h..s...........s.h...................................sHP.hHl...HG..h.p...F.p..l..l..sp.....ss.s..................................................................................p..s..s.h.+D..T..l..t......l....s...................ssh...s..tlthph......................-..ss.........G....s.Whh......H......C.................H.....lh........H..hs.......t..Ghhh.hhh....t....................................	0	653	1565	2232
+7562	PF07732	Cu-oxidase_3		Multicopper oxidase	Studholme DJ	anon	PfamB-43 (Release 14.0)	Domain	This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.50	0.71	-4.37	121	9918	2012-10-02 17:41:00	2004-06-30 09:10:05	10	110	3033	407	3010	9791	561	100.50	30	22.68	CHANGED	plphsshshhsts...ppshslNGphPGPslpsppGDplhlpVhNpl...sps.solHWHGlpphtssh.DGssulTpCPItP.GpsasYpFplpp..tGThWYHuHhsh...p...sGlaGslllpspts	...................................................h..................hhhh.s.....s...t.....h.........G....P......h....l......php...............G........-t.l.............lph....h.....N..............ph..........s..................p....................s.......h............o....l..............HW.................H........G.....l............h...............h...........s............s.............................D...........G..........s........s..................t....................h............s...........p............s..........s..............I.......t.......P..........G.........p.........s.........a....s....Y..p...F........p.....s........p.........p......................s.........G.........T............a..........W.........YHuH..t...............p.h..tGl.hG..hllps...................................................................	0	695	1662	2404
+7563	PF07733	DNA_pol3_alpha		Bacterial DNA polymerase III alpha subunit	Studholme DJ	anon	Pfam-B111 (Release 14.0)	Family	\N	22.00	22.00	23.70	22.40	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.23	0.70	-6.04	89	7657	2009-01-15 18:05:59	2004-07-01 10:32:47	7	67	4508	9	1594	6277	5227	405.60	35	36.47	CHANGED	phLpchshpGl..ccRh.................................h.pRLchELslItph......GFssYFLIVtDhlpaA+p....pGI.VGsGRGSuAGSLVAYsLsIT-lDPlp...........................................asLLFERFLs.ERsshPDIDlDFspc+RpcVIpYVtc+YGc......-pVAplsTauThtuKuAlRDVuRsh.......shs.s.hstlsKhls.........sh............ptshp.p........phpphht.p..........phpclhclAppl...-GlsRpsupHAuGlVI.usp.sLs-hsPlhhssps..........................tthlTQa-hcs.lEshGLlKhDhLGLcsLThIcpshchlp.................tp.......tth............h.....s............l..tsIP..h-Dt.psac.hlspu................cThGlFQlESpuhpshLpcl+PssFpDllshsALhRPGPhp.......t.lpsalpR+pG......ptlpa.ps.........lc.lLppTaGlllYQEQlMplu..phhAGaohGcADhLRRAMuK.Kc.p.htc.+p.....pFhpGhhcpu	................................................................t..LtchshpGh..cc+h...........st......tt...................................................hpcRL-hELslItph........GFs.sYFLIVh-hlpau+s...........................p.Gl...V.G.sGRG.SuAGSlVAYsLtIT-.lDPlp.....................................................................................................a.sLL.F..ERFLNsE......R....s......shP.DIDlDF.s.t..........c.p.....RscVIpYV.tcpY...G..c........-.pV..uplhThGTh.tu.......K.ssl+.DVu+sh...............sh.s.t.hstl..s+h.ls.t...............sl...................tthht.p.........................................ph..t..p..h..h..t...t.p...........................................cspclhchAptl...-.G.lsRpsuhHu........uGlll..ssp.s.......lh-hsPl.hssps.............................th.lTQ.a.-hps..lE......t.hGLlKhDhLGLcsLThIchshchlp............................................................tp....................t...........h.....s.....................l...pp..I..P..........h-.Dt...p.......s...ap..hhppu.....................pThGlF..QhE.S.puh+phLc..c.h...........+...Ps...........s..........Fp....Dllsl....s...uLhRPGPhp.......s..lps....al.cR+pu...............p........l......p.h.ps.................lc.lLt.....p....ThGlllYQEQlMplu..t..hhuGaohGtAD.hLRRAMuK..K....p.....p...h.tc.....+p...tFhpGhhpp.....................................................................................	1	562	1068	1361
+7564	PF07734	FBA_1	DUF1607; 	F-box associated	Studholme DJ	anon	Pfam-B128 (Release 14.0)	Family	Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.44	0.71	-4.55	99	950	2012-10-01 23:07:08	2004-07-01 11:05:26	8	29	37	0	484	1107	0	142.20	20	39.04	CHANGED	uVSLKGNTYWhAp.........ccppt.......................a.llsFDFosE+...Ft.shlsL..Paptt..............sshsLS.sVR.-E.+LulL..hQ.......ptpo.p......hEIWlTs.K..I-ss......sVSW..spF.Lpls.hpsh......sth.............ssSFF.lDE....-K.Klsls..hc...pptppt..............shhYIl.G.cs...thhpcls.......................hhPhhh..s.YVPS	..............................................................l.lpGshYWhup.........cppp....................................................h.llsFDh.s.s.Ep...F..t.h..l...L..P.hptp...................thphhsL....h.ht....p-..pLs.hh....hp............p.p..s..p.......h-IWlhs..c....hcss......psSW.....oKh..h...sls..h..h......................................h...................................................................................................................................................................................................................	1	160	208	232
+7565	PF07735	FBA_2		F-box associated	Studholme DJ	anon	Pfam-B128 (Release 14.0)	Family	Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.54	0.72	-4.12	141	1899	2009-01-15 18:05:59	2004-07-01 17:02:22	12	25	5	0	1889	1923	0	70.40	21	21.44	CHANGED	tpt.phppll...spNh....pplph.........t.phsLs-LL..hhNssplpl..tp.s.....lo.sc-lNlFLKH..WlpG.usscLchhplp	.....................................................ph.........pplplt.............psphlsl.-.cL.L...th..s.sp.p.l.p.l.....pp..sp......lo..sc-l.NpFlKp..W.h..p...G...sp.s.pLchlpl.t...................	0	176	183	1889
+7566	PF07736	CM_1		Chorismate mutase type I	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].	21.20	21.20	21.20	35.40	21.10	17.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.31	0.71	-10.46	0.71	-4.01	57	434	2012-10-01 19:40:00	2004-07-07 16:22:31	6	2	424	49	151	378	287	116.20	43	92.42	CHANGED	lRulRGATTlspNosctIhpAspELlppllpcNslps.--llSlhFosTpDLsAsFPAtsARph..GW.psVPLlsspEhsV.GuLs+CIRVLlahpospsp..tclpHVYL+sAtsLRPDls	....hRuIRGATTl-pNst-pIhpATpELlpcllppN.plps.-DllSlhFTsTpDLsAsFPAtAsRph.......G.a.ptVPLhsspEhsVsGuLs+CIRlhlpssocp.sp..pcIpHVYL+sAtsLRPDL.s.....	0	67	120	140
+7567	PF07737	ATLF		Anthrax toxin lethal factor, N- and C-terminal domain	Andreeva A, Bateman A	anon	Pfam-B_23800 (release 14.0)	Domain	The C-terminal domain is the catalytically active domain whereas the N-terminal domain is likely to be inactive.	21.40	21.40	23.10	22.90	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.60	0.70	-4.96	4	70	2009-09-11 08:46:23	2004-07-07 16:59:27	6	7	32	77	5	78	0	187.20	36	41.50	CHANGED	hK.-hhpplV+l-lps-phsKtptspcLlcKlPp-VLEhY.pslGGcIYlsDt-lspHhpLpslScccphlhsupGcph.htp+FVFsKtshpPhLlIps.cDYs.sp.pShpVYYElGKuI.hDhhS.pthcLtsP..cFlshlsplsst..........DpDupDLL.....FspphKE....cspslslsalcpN.sEFQcsFAcAFuhYapPcH+-sLclY..APchFpYMschpchthp	.........................................K.-.h.p.sphph.spphsKh.th.chhchls.sVhphY.ptlstphYhh..-hhpphp.p.lpc.pp..hs..G.......+aVatc.t..shh.....pD.h.pp.puhtlYh..u+.l.hch.S....pl.ps..tFlp.htph.s...........DpsupDLl.....FpphhKE....cspsl..s.l.s....alcpN.sEF.chFAcAFuYY.a.sP..D........H+shLcla..APcsFpYhschpK..hp......	1	1	4	4
+7568	PF07738	Sad1_UNC		Sad1 / UNC-like C-terminal 	Wood V, Finn RD	anon	Pfam-B_5052 (release 14.0)	Family	The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development.  The S. pombe Sad1 protein localises at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain [1-2]. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2 [1].  The SUN domain of Sun2 has been demonstrated to be in the periplasm [2].	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.70	0.71	-4.37	25	1140	2012-10-03 19:46:52	2004-07-08 10:09:58	8	33	300	4	758	1131	30	126.30	24	15.87	CHANGED	hshtupsspsllpps...hhsusCauhpuspsalslcLuctIhlpslsltHhpp.......h.SSAPK-FpVhuppphsptp.......hhhLGpFph.stsspshQoFplpss..t.......hhchV+lclhSpa....GsstasslhtlRVaGps	..............................................................................................h....ttsspsll.p.s...hh.ssC.h.s.....h...p.......s......p......p.....s...a.l......s.lcLsp.I.hssslslpH.hth...........h.sSuP+cF.plh.....u..................p.p..sspp.........................hh.hL..G.p.....aph...s....p..s..s....p......s...l.....Q..s.F.t.l...p...pt..........................hhphlclc.lhSpa.....Gp..ta..ssl...t.hRVaGp...............................................	0	233	353	597
+7569	PF07725	LRR_3		Leucine Rich Repeat	Studholme DJ	anon	PfamB-184 (release 14.0)	Repeat	This Pfam entry includes some LRRs that fail to be detected by the Pfam:PF00560 model.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.38	0.73	-6.54	0.73	-3.89	74	609	2012-10-02 21:32:02	2004-07-26 15:33:50	7	122	16	0	284	634	0	19.90	51	2.28	CHANGED	pLVcLphttS.pL.c+LW-Gsp	....LVELshppS.pL.EKLWcGsp...	0	96	177	191
+7570	PF07739	TipAS		TipAS antibiotic-recognition domain	Bateman A, Finn RD	anon	Pfam-B_8785 (release 14.0)	Domain	This domain is found at the C-terminus of some MerR family transcription factors. The domain has an alpha-helical  globin-like fold [1]. The family includes Mta a central regulator of multidrug resistance in Bacillus subtilis.	23.70	23.70	23.70	24.00	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.49	0.71	-3.78	164	1938	2009-10-27 17:45:06	2004-07-27 13:56:40	8	15	1353	3	329	1455	73	113.30	19	48.65	CHANGED	paspEspp+aGp...pthpt.ttp............thsc.pchpphppp....hpplhppltphhpps..sssupcspplscpapphl.s....pahs.....hstp........hhtsL...uphY...hsD.t+Fpphhc.ph.....st.Ghu.palpcAlptas	........................................................atpEh.pcaGp...p.htp..pc...................sp..pc.pphppp........hsplhpplsphhppt...sssupcsQphspcahphlp....phhs.........hs.c.........hhst..l...uphY..............hs-...sc.Fpp.....h..s..ph.............ss..uhu..pals-Altha..........................................	0	107	213	277
+7571	PF07740	Toxin_12		Ion channel inhibitory toxin	Bateman A, Finn RD	anon	Pfam-B_20319 (release 14.0)	Domain	This is a family of potent toxins that function as ion-channel inhibitors for several different ions. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses [1]. Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons [2]. Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels [3]. Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels [4].	21.00	21.00	21.00	21.40	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.46	0.72	-3.46	31	254	2012-10-01 22:06:18	2004-07-27 13:59:12	7	1	24	18	1	274	0	30.60	39	40.83	CHANGED	-CtthattCssss-.CC..tshsCppc....h..pa..Cta	....-CttahspCs.sps.CC..sthsCpsc....a....+W..Csh.......	0	0	0	1
+7572	PF07741	BRF1		Brf1-like TBP-binding domain	Bateman A, Finn RD	anon	Pfam-B_18050 (release 14.0)	Family	This region covers both the Brf homology II and III regions [1]. This region is involved in binding TATA binding protein [1].	25.00	25.00	27.40	26.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.38	0.72	-3.77	42	348	2009-09-11 07:42:02	2004-07-27 14:01:28	8	11	267	4	234	338	3	99.70	33	16.01	CHANGED	D-.E..lcthl.LsEcEschKpplWhphNc-aLhcpcpKp.........................h+tctcp...........psstpcc+p++tpcpp..................................sssspTAuEuscphLpc+s..hSpKINY-sLcsLa	................................D-.E.lc.phl.Ls-pEs.clKpplWh..p.Nt-YLc...cQppKc..........................h+t.ttcpt.........................tthp.c++....++sp.cpct.......................................ss.usTAuEAhcpML.cc+p....hSpKINYcsLcsL.............................	0	79	129	192
+7573	PF07742	BTG		BTG family	Bateman A	anon	Pfam-B_9208 (release 14.0)	Family	\N	23.00	23.00	24.10	25.70	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.61	0.71	-4.59	31	473	2009-01-15 18:05:59	2004-07-27 14:07:20	7	7	125	8	259	429	1	113.10	44	43.74	CHANGED	MptElssuVsFls+hlpp+th...LsccplphFupcLpphLhc+YpsH.WaP-pPpKGpuaRCI..RIN...cphDslltpA...............spcSGLshpcLh..LPpElTlWlDPhEVshRhGEcu.shsVhhhp	.........................Mp.EItsAlsFlhphLhs+......Lscc...plphFuppLpclL.pc............+Y.c.sH.WaP-+PtKGSua.R.CI.....+Is........cph....DPlltpA................upcuGlshp-lt.t....L.P...........p............E..L........olWlDPhEVSaRlGEcG.shpVhh.p...................	0	61	82	156
+7574	PF07743	HSCB_C		HSCB C-terminal oligomerisation domain	Bateman A, Finn RD	anon	Pfam-B_6234 (release 14.0)	Domain	This domain is the HSCB C-terminal oligomerisation domain and is found on co-chaperone proteins.	21.60	21.60	21.60	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.46	0.72	-3.52	143	1500	2009-01-15 18:05:59	2004-07-27 14:15:24	8	10	1465	13	424	955	122	77.40	34	40.93	CHANGED	htDs..tFLMppMEhREpL--httt....pst.spLpplppclppphcphhpplspth...s........ppshppAsctlp+L.......+Fhp+.lppclcp	.....................s.pDssFLMcQhElREcL--lptt...........cs-.spLcshhpclcphhcsthpphsppL........-...............spsassAA-pVRKL..........+FlcK.Lpsplcp.........................	0	114	216	329
+7575	PF07744	SPOC		SPOC domain	Bateman A	anon	Bateman A	Domain	The SPOC (Spen paralogue and orthologue C-terminal) domain is involved in developmental signalling [1].	21.30	21.30	21.40	21.40	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.72	0.71	-3.63	58	707	2009-01-15 18:05:59	2004-07-27 14:20:39	8	40	232	1	436	686	1	115.20	24	8.36	CHANGED	WpGh.lshpshsphsspuphlsGp...ppls.ptl.........................................................PtplshpuRlchppltchhpplptst......plhllsl................ssppspts.........hpp.hhsYhps+pR.h......GVhplss.................stshYlh.P	..............................................................................WpGh..lshp....s.....s....p....hssphahlsGs.....tplh.pp.tL.........................................................s.pIs..phRls..splpchhpclpsus.st.......thhllsl................t.s..ss.tpppps...............hps.lhsYLpp+pt..s.GVh.sl.ss...tt..............stslalhP................................	0	106	174	299
+7576	PF07745	Glyco_hydro_53		Glycosyl hydrolase family 53	Bateman A, Finn RD	anon	Pfam-B_5764 (release 14.0)	Domain	This domain belongs to family 53 of the glycosyl hydrolase classification [1].  These enzymes are enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known [2] and has a TIM barrel fold.	20.70	20.70	20.80	21.10	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.22	0.70	-5.65	16	584	2012-10-03 05:44:19	2004-07-27 14:21:50	8	37	453	23	213	550	107	322.00	33	69.58	CHANGED	h+GsDlS.lhp.........................................hEpsGss..apssNGpppDhhplL+s.sGlNhlRlRVWssPhD..............G.sDlccslphAKRAcstGM+lh.lDFHYSDpWADPu+QphPpAWssh.sh-pLpps..lYsaThssLssh.pcsGlpsshVQVGNEhssGhLWs.Gp........sssasphupLlpuGhpAV+-..........lssssKlhlHLssGts.sp.phaacpltpp..G....sDaDlhGlSYYP...aWpu..........oL.....ssLpssLpshtspYsKsVhVsETuaPao........s..sp.t....h.shPhospGQsshlpslhplVpsl........scGlGlFYWEPAWlsss.....................................h.tGsshssp.shFD..hsupsLsSlssF	..............................................................................................h+GuDlShl.p.........................................hEp.p.Gsp..ahs..t..s...G.........t...p...p.D...hhplL+s.pGlNhlRlRl.WssPts............................................G....ss..hs.pslthA+..RA+stGh+lh.lDFH.YSD..hWADPu+QhhP.....pAWtsh........shspLp.ps............lasaTtsslsth..cptGl.......P-hVQlGNEhssGh..L......WstGp...............................................sssa.sp..hAtLlpuGhpAV+c..................sssp.s+l..hlHls.s........Gt.....s.s..s.......t.......h........p...a...aacpl.ppp.....s..........scaDlIGh.SaYP...........aWpu.................sh.......ssL..p..sshs...sls.p+.Y.s..K.c.lhVsEsuasas.t..s.t....s.hst.t.............sh.shospGQtphlpc...lhpt..ltsl.t......spGhGlFYWEPsWhs.s...................................................h...Gssh..tst...shFD...pGp.s.h..uht...............................................................................................................	1	77	147	182
+7577	PF07746	LigA		Aromatic-ring-opening dioxygenase LigAB, LigA subunit	Bateman A, Finn RD	anon	Pfam-B_18522 (release 14.0)	Family	This is a family of aromatic ring opening dioxygenases which catalyse the ring-opening reaction of protocatechuate and related compounds [1].	23.40	23.40	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.48	0.72	-3.98	40	275	2009-01-15 18:05:59	2004-07-27 14:23:53	6	3	207	4	91	247	101	83.40	30	44.05	CHANGED	LNpashoL.hcspsRccFhuDccAhh-casLocpp+pAlhsRDhtthlphGuNhahLtKluulhGlsh.phsusMsG..hoh--apphhhs	........lNcahhpL.hcst.RpcFhs...D.cAhhccauLoc-p+pAlhsRDhtsLlphGsshahLtKh..uus.Ghs..phhu..shpG...oh-patthh..s............................	0	18	46	75
+7578	PF07747	MTH865		MTH865-like family	Bateman A, Finn RD	anon	Pfam-B_25445 (release 14.0)	Family	This domain has an EF-hand like fold.	25.00	25.00	35.20	34.90	21.90	20.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.53	0.72	-4.35	6	69	2009-01-15 18:05:59	2004-07-27 14:27:15	6	1	56	1	52	72	0	75.50	37	86.51	CHANGED	--l+tpll-hhKsA-.FPIps..ELhuALPsGhsToCp.Gs.ElpAuEhs.KLlTcsDFPaKsu-plADpll....c+suL	..p-l+tQlh-uhc..sAc..FPIpo.h-LlsALPsGssTsCpsGs..hpl.TAtEhs.KllsssDFPacsA-slA-sll....pcs...........	0	12	35	46
+7579	PF07748	Glyco_hydro_38C		Glycosyl hydrolases family 38 C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_731 (release 3.0)	Domain	Glycosyl hydrolases are key enzymes of carbohydrate metabolism.	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.64	0.70	-5.68	45	2571	2012-10-02 23:57:29	2004-07-27 14:36:28	8	30	1251	65	913	2233	104	416.20	15	45.85	CHANGED	tslhlaNshsappsphVplssstsshthtstp..........................................................hhh.hsplPsluhtsh.ht.spt.p.tt...........................................h.l.....cNshl+lphsss.GtlpolhDcpss+chh.........hspphthacs...................hptt.p.t...h...usuh.hh.....ppsshpstl.h.ht................................tsshlsphlplhsss................ppl-hcspVc.hpppcp......lpspFssslpu......................spshY-sphGhhhc........shphs...s.h-tsha...........plssptalp.uc...........slulLs-staGsss............tssplcLoLhRs.........................................................cstsD...pupthh............saslhscssshhtht...................ssptuh.............plptPhhh....................hptht..s..h.hsls..sl.................hh.thK.scst..................pshlL+hh-htsspsctplth.shs.ttsph..pslh-t............................................................................................................t.pspphplplpPhEItThp	......................................................................................................................................hhlaNs.s..h..p..t..h......l.....p....h.........h.......................t..............h...t.................................t..........................................................................................................................................h.h...........p....lPsh.u.h...p.sh......ht............t.t......................................................................................................................................................................hhl..........pNt..h...hpl.ph..s..t.p....G..h....l.p..pl...h....c...p..p..s...s.pp..h...................................hssph.hhaps...........................................hptt...................st..s....h..hh...................p..ss.hpst.h..hphph..................................................................t....p...........t........l....p..p..h..l.p.l..htss........................ppl-hc..s....p.lc...htppcp.......................L.+l.th.ss..s..l.p.s......................pps.h.h.p.t.t.h.GhhtR..........................................shp.p...........pshpt..sh.h......................h...s.....t.....t.t.....a...h..p...h..sc......p.............................slul.hspshh.uhs.s...........................ss.p..l.pl..o..L..hRs.........................................................pshs.D..........ps.pthh........................................................paul.h.sps...t...h......ht..............................................shppuh............................................th.p.t.Ph.hh.............................................................hp..h.............................s.h...p..h........s..l................................................................hpshK.up....st............................................................................tthllR.hhp.....t.t..t.s.p.s.t.h............s...........sp......h......slhpt..........................................................................................................................h...h...t...shplhoh.................................................................................................................................................................................................................	0	333	530	740
+7580	PF07749	ERp29		Endoplasmic reticulum protein ERp29, C-terminal domain	Finn RD	anon	Pfam-B_5062 (release 14.0)	Domain	ERp29 is a ubiquitously expressed endoplasmic reticulum protein found in mammals.  ERp29 is comprised of two domains. This domain, the C-terminal domain, has an all helical fold [1]. ERp29 is thought to form part of the thyroglobulin folding complex [2].	21.70	21.70	22.40	23.30	20.10	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.07	0.72	-3.36	36	300	2009-09-11 09:36:09	2004-07-27 17:35:15	7	10	234	12	194	303	6	91.90	30	27.52	CHANGED	GsltsLDplltcassus...tptppllscscctsppLp.....st...+aupaYl+lhcKlhpps.......p-YspcEhpRLc+lLp......GulussKtDElhh+tNILppFt	..................................................GpltslDslstcahsus.t..pppp.....pllpcscctspplp...............tttt..chAchYlKlhcKlhcpu.......p-asppE.hpRLp+lLp.......sslus.sKtD-lpt+.hNILpsF..........	1	70	115	159
+7581	PF07750	GcrA		GcrA cell cycle regulator	Thanbichler M, Finn RD	anon	Pfam-B_23428 (release 14.0)	Family	GcrA is a master cell cycle regulator that, together with CtrA (see Pfam:PF00072 and Pfam:PF00486), is involved in controlling cell cycle progression and asymmetric polar morphogenesis [1]. During this process, there are temporal and spatial variations in the concentrations of GcrA and CtrA.  The variation in concentration produces time and space dependent transcriptional regulation of modular functions that implement cell-cycle processes [1].  More specifically, GcrA acts as an activator of components of the replisome and the segregation machinery [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.14	0.71	-4.04	8	480	2012-10-04 14:01:12	2004-07-27 17:35:51	6	7	310	0	157	401	1392	140.20	30	85.47	CHANGED	MsWTDERVEtLKKLWp-GLSASQIAAQLG.....GVSRNAVIGKVHRLuLoG....Ru+s.t.osAssRs++ss.s.t.........................ssutpuLphchss-lsscsshtsstssVsshsRplpLLELuE+oC+WPIG.DPtsE-FsFCGs.cus-uuPYCshHuRlAaQPsuc+RRsc	...........................................................................pWT-E+lp..hL+clW.tcGhSuupIAtpL.G......loRNAVl...GKsH.R..L.t..Lss..........+sp..s................t.....t.s.s.....p...t..tst...................................................................................................tt.h......t............t..................................t.............tt.h..tl.h...pL.....sc..p.....pC+WPl.......G...-P....s.....cFh.FCGt.....ts...tu....PYCt.H.s.tlAapshttp....t...............................................................................	0	40	96	114
+7582	PF07751	Abi_2		Abi-like protein	Fenech M	anon	Pfam-B_8740 (release 14.0)	Family	This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins,  which are involved in bacteriophage resistance mediated by  abortive infection in Lactococcus species [1,2]. The  proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function [3].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.43	0.71	-4.12	111	1544	2009-01-15 18:05:59	2004-07-28 09:55:11	6	5	1091	0	266	1249	75	178.60	18	63.71	CHANGED	pphLpp.luYaRl.ssYhhsh.t.t.....................htts.spFpplhpLYhaDpcLRthlhcslpclElslRstlstt..lup.............t..ha.p.tphhptt.............................................hhpphp......pplpcspt....p....hpaatpph...........tthPhWhhh.....ElhshG....................phsphap.h.tp.............ttplspp...............hs...............hp.........tphlpshlcslphlRNhsAHasplasp	...................................................................Lpp.hs.Y.a.ph.psYhh.h...............................hh.s.hphpplhsL..YhhDpcL+thhhphlttlEhsl+stlsth..lsp...........................t....h..ahp......phhpt.t.........................................................................hhpphp.......ptlpcsp..............t...........hpphh.pph.........................................tphPhWhhh........chhshG......................phs.phap.h...t.................t.thh.pp................................................ht.......................................hp........hp.ht.s..h....lptlp..lRNhsAHpp.lht........................................................................................................	0	72	163	220
+7583	PF07752	S-layer	DUF1608;	S-layer protein	Fenech M, Eberhardt RY	anon	Pfam-B_2293 (release 14.0)	Family	Archaeal S-layer proteins consist of two copies of this domain [1-2].	30.00	30.00	30.70	30.30	29.60	29.70	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.46	0.70	-5.18	14	125	2009-01-15 18:05:59	2004-07-28 10:41:59	6	15	13	0	123	125	2	236.20	27	60.47	CHANGED	lRGslaD.........s.stssshsWsspsFuGFYYslccs..................lsoEshslhthss..scsIs-GsLVYsTpsh.spaEht..............sW..ssYpllGFhuccYhAs.sDss.............stLuplllD..u-DKcsl.hoG-sh-Lt..............cGYSLplspVDVsGs+VWlpLpK-G-hlDsshlsssss.......alacs-lu-s...-DlshhhlalspVFtGspsohlhlcula.Is.DshlcIpsGDpFGchElsphSpssIphcN-DohoLspsss..hplhsshhFpsuD	..............................................h..........................h.Wss......satuFaYslsps................htsEphth.........sp.ltc.....s..s...l.Ypo..p......s...p...acht..............sh..tpY.h..luahu-cYhshhssss........................spLu+lLlD.........s-cctol.psGpsLs.Lt..............-GYsLplppl...Dl-Gs+ValpLpKDGphVDspllssus..s.............asYcp.-lsst...pDlslltl+lc.plFpGsp...sshshl-GlaQIu.-shhplppGDpaGphclppls.....t...s..t..I.hpNp.s.s.hsLppsps...tlhtth..htsus..................................	0	26	83	92
+7584	PF07753	DUF1609		Protein of unknown function (DUF1609)	Fenech M	anon	Pfam-B_2149 (release 14.0)	Family	This region is found in a number of hypothetical proteins thought to be expressed by the eukaryote Encephalitozoon cuniculi, an obligate intracellular  microsporidial parasite. It is approximately 200  residues long.	25.00	25.00	56.80	56.70	16.70	15.80	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.52	0.70	-5.03	9	42	2009-01-15 18:05:59	2004-07-28 10:43:16	6	2	6	0	26	42	0	199.40	58	45.79	CHANGED	EsEputEAEssh.Eh....AtsK+KsutcKScGtc+pYKlH+RVLRWpKSsE+IKcELDcGpEE+W+G+SlEEI+EQKhlHDIsEVhcLLRSc-.sD+FFhcTG+YMKGGSERW+MVAlGlLEpGGcK+lGsVEVGLFKsc.sGpsVlYHLMF+PTshEctGcVsssuFu+uDDV-cI--s..-spDhuGFpYPpGVRsEhV+ssspF+IVWRNP+sTSEVLRoLTlhphPpl	............EsEtutEsEhs..Eh....uss+cK....su.K.....KScGsc+pYKIH+RVLRWpKSPEKIKcEhD+GSEE+W+GRSlEEIKEQKhlHDIstVlcLLRScD.AD+FFhcTGcYhKGGSERtRMVAIGlLEsGGc.+hsGVVEVGhFKDs.sGssVVYHLMF+sTthtphGtsht...sthschss.lttlcct..c.pD.ttF.YP.slp.EhspttstFpI.ats.psTu.llppLhl.phs..................	0	26	26	26
+7585	PF07754	DUF1610		Domain of unknown function (DUF1610)	Fenech M	anon	Pfam-B_8731 (release 14.0)	Domain	This zinc ribbon domain is found in archaeal species. It is likely to bind zinc via its four well-conserved cysteine residues.	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.78	0.72	-7.06	0.72	-3.81	21	205	2012-10-03 10:42:43	2004-07-28 10:44:10	6	2	117	0	143	189	34	20.80	46	59.03	CHANGED	CpsC......RchussasCPpCGh	...CppC.......Rcp..ustahCPsCGh.	0	38	81	115
+7586	PF07755	DUF1611		Protein of unknown function (DUF1611)	Fenech M	anon	Pfam-B_8752 (release 14.0)	Family	This region is found in a number of hypothetical bacterial and archaeal proteins. The region is  approximately 350 residues long. A member of this family (Swiss:Q6M063) is thought to associate with another subunit to form an H+-transporting ATPase, but no evidence has been found to support this.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.71	0.70	-5.77	79	333	2012-10-05 12:31:09	2004-07-28 10:48:20	6	4	302	6	140	392	459	289.80	34	83.25	CHANGED	h-..hchsGpsss........tslPlhsshpts.....ttsscslllGlAstGGhls.tsWppslhpAlctGhslsSGLHs.hL......s-cPclsthApp..tGtplhDlRpP.stsh.tlusGpt+...........t.sspRlLsVGTDCulGKhsTuLtlpcuhppcGlcusFhATGQTGIhI.uGpGlslDAVsuDFsuGAlEtll.csst.....pp.chhllEGQGSLh...HPuauu.....lohuLL+GupPDullLsHcssRpphcshsp...hsl.Pslpphlplhptlushs........spVlGlu.lNTpsls..-pp.utphltchppch......uLPssDPlRp..G.ss..pll	.................................phsGppss.........hslP.hs.hpss........stsscsLllGlAstGGhls..ptWhpslhpAl.ctGhslsoGLHp.hL......s-.sclst.hApp..pGt..plaDVRps.s.sh...slusGpt+.............sucRlLsVGTDCulGKhhTuLtLccshcc+Ghc...u...sFhATGQTGI....hI..sGpG.lslD.....A...VluDFhuG...AlEtls.css......cc.ch.llEGQGSLh......HPuauG.......VohuLl+GuQPDullLsHcssRpphcshsp...hsl..Pslpphlchh.thuphs.......stspllGlu..lNTptl....s..-p.c.Atthhtchppch......ulPssDPlRh.Gsstl...................................................................................	0	35	86	119
+7587	PF07756	DUF1612		Protein of unknown function (DUF1612)	Fenech M	anon	Pfam-B_8688 (release 14.0)	Family	This family includes sequences of largely unknown function but which share a number of features in common. They are expressed by bacterial species,  and in many cases these bacteria are known to  associate symbiotically with plants. Moreover, the majority are coded for by plasmids, which in many cases are known to confer on the organism the ability to interact symbiotically with  leguminous plants. An example of such a plasmid is NGR234, which encodes Y4CF, a protein of unknown function that is a member of this family [1]. Other  members of this family are expressed by organisms with a documented genomic similarity to plant symbionts [2].	30.10	30.10	30.60	49.50	27.90	30.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.72	0.71	-4.05	18	141	2009-01-15 18:05:59	2004-07-28 10:54:13	7	2	98	0	42	113	1	126.70	55	35.37	CHANGED	sLlaDsDWDE-sRLsEWRuVlspscsL..PPlLpAAlhhDAWppLEsLQ+usWLGRLLsAuhLRpcGhss.uHLsulshGLKslPh-RRRpRsRtoRLhuhLcultsAAptGhKEHDRLslARp.MpR+LcG	..............tLlYDsDWDEDuRLpEWRss.hststsL..PPlLpAAlhaDAW.pLEVlQRusWlGRLLsAuaLRpuGlsu.sHLsAlsLGL+shts-cRRupsRssRLtsFLtAlptAAEssMKEHDRLhLARcQMpRKL+G.......	0	4	19	29
+7588	PF07757	AdoMet_MTase	DUF1613; 	Predicted AdoMet-dependent methyltransferase	Fenech M	anon	Pfam-B_8934 (release 14.0)	Family	Proteins in this family have been predicted to function as AdoMet-dependent methyltransferases [1].	20.20	20.20	20.20	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.45	0.71	-3.95	3	246	2012-10-10 17:06:42	2004-07-28 10:55:27	8	4	214	0	186	308	53	106.20	44	20.68	CHANGED	LV.NlEKYNDLYsELKQKYuQpLV-pW...sEsTDPtKFVFEDLAIAAYLIhLW+QTpSu...pp.pSFVDlGCGNGLLVYlLsuEGY+GYGaDlRKRKLW-hYPs-sQVcLhEKslVP	.......................................................l.s..papshYtpLKpKYuppllcsW.......sE..sTDPpKaVaEDlA..IAAaLl.LW..p.p....h.sp........................pth.....u.........FVDlGCGNGLLVaIL.pEGa.pG.h.GhDsRcRK.Wsha.s...spsp..L...................................	0	54	91	149
+7589	PF07758	DUF1614		Protein of unknown function (DUF1614)	Fenech M	anon	Pfam-B_8844 (release 14.0)	Family	This is a family of sequences coming from hypothetical proteins found in both bacterial and archaeal species.	22.40	22.40	22.60	22.50	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.20	0.71	-4.54	48	186	2009-01-15 18:05:59	2004-07-28 10:56:30	6	2	156	0	112	170	2	169.60	31	72.00	CHANGED	llGShI.....NIPltp..tt............................hhGh.h....Ph..h..tpshlAlNVGGAlIPlhlulY..Llhp....h.......tsllusllsullsahhu+sl..........sGlGIssPshlsPlsAulsAh....lhuttht..............sAYluGslGoLlGADllpL...t...clhphs.ssh..l.......SIGGAGsFDGIFloGllAlLL	..............................................lhsS.hNlslhp...t..............................hhsh.h.h...s.........pphlAlNlGGAlIPlhlulY...Llhc..........t.hltsllusllsullsahhu+sl.........sGlGI.hhP...salsPllAu.l.hAh...........lhuht.hc.................sAYluGslGsLlGADllpl.........t....plhphu...ssh...l..............SIGGAGsFDGIalo...GllAlLL...........	0	46	80	98
+7590	PF07759	DUF1615		Protein of unknown function (DUF1615)	Fenech M	anon	Pfam-B_8943 (release 14.0)	Family	This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. Swiss:Q8Z8Z7, Swiss:Q8ZRF4) are thought to be lipoproteins. Another member of this family (Swiss:Q93SV8) is thought to be involved in photosynthesis [1].	25.00	25.00	26.30	26.20	20.90	18.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.94	0.70	-5.67	22	632	2009-01-15 18:05:59	2004-07-28 10:58:44	7	1	622	0	68	326	17	315.30	72	86.98	CHANGED	uslpDRpGWApDItsAhps.tlssoscNlCuVLAVsEQESsFpsDPsVPGLu+IuhpEI-pRAs+h...........tlPthllcsALphpSP.sG+oYpcRlculRTE+-Lstla-Dhl...........stlPhGppLFus.....hNPV+TGGPMQVSItFAEp+u+...tYPasss.uolRcEVFoRRGGlaFGhA+LLsYPssYspslYRFADFNAGaYASRNAAFQsAlSRloGhtLALDGDLlpYss.......stsusTEhAlhsL..upcL...shscspIRcsLcptcs.sFpcTtLYcpVasLA-+psG+shPRAhLPtIpLcSPKI.oRpLTTAWFAcRVDpRap+CMpR	....A.SVKDR-AWAKDlATTFcSQGLAPTlENlCSVLAVAQQESsYQADPsVPGLSKIAWQEIDRRAERh...........HIPuFLVHTALKI+SP.NGKSYSERLDoVRTEKQLSAIFDDhI.............uMV.PMGQTLFGS.....LNPV+TGGPMQVSIAFAEQHsK...GYPWKMD.GTVRQEVFSRRGGLWFGTYHLLNYPAsYSAPlYRFADFNAGWYASRNAAFQNAVSKASGVKLALDGDLIRYsS.......KE.PGKTELAsRKL..Au+L...GMS-uEIRRQLEKGDShuFE-TALYKKVYpLAEAK.TGKoLPREMLPGIQLESPKI.TRsLTTAWFAKRVDERRARCMp.......	0	11	22	43
+7591	PF07760	DUF1616		Protein of unknown function (DUF1616)	Fenech M	anon	Pfam-B_8886 (release 14.0)	Family	This is a family of sequences from hypothetical archaeal proteins.  The region in question is approximately 330 amino acid residues long.	31.60	31.60	33.10	32.70	31.40	31.20	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.80	0.70	-5.27	38	205	2009-09-11 00:12:54	2004-07-28 11:00:14	6	5	101	0	137	214	7	244.00	22	72.95	CHANGED	Lhlllhhsllshlhlh.hssht...pohlRslLGlsh..lLFlPGYsLlusLaP................p+psLss.....lERh.sLShGLSIullsLlGLsLNaos.......huIchhPlll.oLshhollhshlAhhRRtphPssctath.hpthh.t................hhhtsssph-phLsllLllullssls.slsaslhhPcpsEpFTEFYlLG.pt....hAtsYPsphhhGpptslhlG.................lsN+EhpshsYslclhLpspphs.......p.ph............slss...p......pohppshphps..hhups.clpaLLapcs...................ppshsY+sl+LalsV	..................................................................................................hhhh.hhhhhhhh..h...........lR...hhhuh.h....lhF.hPGYshlthLaP....................................tttpl.s........l-Rh.slShGl...SlulsshlGlhlshs........hslphhslhh.slshhslhhshluhhR+hph.............h.................................................................h..p.phls.hllhl.llhshh..hhshhhh.s.....tt..s.....ctaothhlls.tt.....hutsYssphh.up...lhlt.................lhNpEhpshtYhh.hhltp..ht.........................th......h......tlst.........s........................tshp..hph..t.........stp...pl.h..hLaptt.........................t.t.shhthhlhlp...................................................................................................	0	19	77	107
+7592	PF07761	DUF1617		Protein of unknown function (DUF1617)	Fenech M	anon	Pfam-B_8981 (release 14.0)	Family	This is a family of sequences from hypothetical bacterial and bacteriophage proteins. The region in question is approximately 150 residues long and is highly conserved throughout the family.	21.10	21.10	21.40	22.40	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.92	0.71	-4.14	2	86	2009-01-15 18:05:59	2004-07-28 11:01:05	7	1	53	0	8	64	1	137.70	43	98.75	CHANGED	MDLTLKNK-LNTLYpVLDKIKlTNMRANRGRAKLLAKV.sKlsEYAKDEhDlID.YsAKscDDKalhD-+tN.KltDsuKLsELNDhLsELAsE.IVIKGGEYSKRFIDFLpaL.EsEDEFTSpEIlLIDNILEQFEES.KGE	......................MplTl+N+-LsslasVL-cIKlpsh..RAsRGRAKLLuKVhcKlcEYAKDEsDLIchYAtKDcDGK.all.D-+.tNh....KL.........s.D.PsKl.....c.....EhNchLsELusEcIsIcGsEYS+RFhDhlpaLt-sEDEhoup-hll...hDplLEpaEtu................................	0	2	5	7
+7593	PF07762	DUF1618		Protein of unknown function (DUF1618)	Fenech M	anon	Pfam-B_8857 (release 14.0)	Family	The members of this family are mainly hypothetical proteins expressed by Oryza sativa.	21.00	21.00	22.00	21.40	19.30	20.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-11.16	0.71	-3.95	61	623	2009-01-15 18:05:59	2004-07-28 11:02:59	9	14	11	0	353	498	0	130.80	21	29.62	CHANGED	W.V..DLs.tGlLhCDsh...s..............t......s....clcalsLP.ss.hssttt....................pt.......hptaRs.lul.....ssG....pl+aVplstt.t...............................................ssshhlssWoL..............ssht..Wph-s.plshsclWstcs............apt.t........l.Pp.......h..h..Phl..uh.cs....slla	......................................W.V.D....Lh...t.G.l.l.h.C..D.sh.....s.....................cp.........splcalsLP..sshh.sttp.....................pts.phhR.s..lss.......spG.....pl+aVp.lptt......................................................tshhlssWsL.................sttpWph..-t..pl.s...hsclhttts..................................h.t.t......l..sp...............hh..h..Phls..ps....thh........................................................	1	0	66	213
+7594	PF07763	FEZ		FEZ-like protein	Fenech M	anon	Pfam-B_8854 (release 14.0)	Family	This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation [1]. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic [1].  The C. elegans homolog, UNC-76 (Swiss:Q7JNU9), may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells [2]) and these roles have also been postulated for other FEZ family proteins [1]. Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells [2]. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta [2]. The members of this family are predicted to form coiled-coil structures [2,3], which may interact with members of the RhoA family of signalling proteins [2], but are not thought to contain other characteristic protein motifs [3]. Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2, Swiss:Q76LN0) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues [3].	28.10	28.10	28.40	29.50	26.30	28.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.55	0.70	-4.66	10	222	2009-01-15 18:05:59	2004-07-28 11:03:54	8	5	82	0	108	181	0	207.80	46	62.63	CHANGED	ShEDLVNpFDEKLolCF+NYsssTEslAP...V+....spoEEEhLpD--lWsALTDNYGNlhPlDW+sSasRsLHhssLN...Lt.......................................pussssspl...cpSDDEELpEphDMHolIluslp.......EEPLhTADQVIEEIEEMMQESPDPE---.........ssspS-slShLppElpuLppussss..............sapEcL+pLSsScLsElL-ElEsAIR-YSEELlpQLAlRDELEFEKEVKNSFISlLI-VQNKQKEa+ElhKKK+KhKususp	..................................................h.sLspph-EKlshCFp..s.t.tst...h.As...Vp......ppcphhptpplW.s.LTsNass.h.hshDWcsopscsL.h.hl....h.........................................p..u...s...s.s...h...cts.--EElpEphDhHShI.st..hs.......-EPLhTA-QVIEE.I-EMMQpSPD.PE--.c........................sss.pSc.thohl....p-hp..sh.ps....s.s...............................tE......pl+pLSsocLsElLcElEssI+-aSEELVpQLAhRDELEFEKEVKNSFISlLl-VQNKQKEp+Eh...hKK++K.+shs..............................................................	0	31	41	69
+7595	PF07764	Omega_Repress		Omega Transcriptional Repressor	Finn RD	anon	Pfam-B_63922 (release 14.0)	Family	The omega transcriptional repressor regulates expression of involved in copy number control and stable maintenance of plasmids. The omega protein belongs to the structural superfamily of MetJ/Arc repressors featuring a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA [1].	25.00	25.00	25.90	29.30	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.31	0.72	-3.61	2	125	2012-10-02 18:44:02	2004-07-28 11:04:54	6	3	97	14	2	49	0	63.30	79	46.87	CHANGED	MIVGNLGAQKtKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKNGGNVKEVM-.tLcphl+phL.s+h	................hGNLGAQKtKRNDTPISAKKDIMG.DKTVRVRADLHHIIKIETAKNGGNVKEVM-htLcphl+phL.s+h.............	0	1	1	2
+7596	PF07765	KIP1		KIP1-like protein	Fenech M	anon	Pfam-B_2332 (release 14.0)	Family	This is a family of sequences found exclusively  in plants. They are similar to kinase interacting protein 1 (KIP1), which has been found to interact with the kinase domain of PRK1, a receptor-like  kinase [1]. This particular region contains two  coiled-coils, which are described as motifs involved in protein-protein interactions [1]. It has also been suggested that the protein's coiled- coils allow it to dimerise in vivo [1].	20.50	20.50	21.50	21.90	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.44	0.72	-4.14	13	269	2009-01-15 18:05:59	2004-07-28 11:06:16	7	8	37	0	153	254	0	66.70	53	8.18	CHANGED	SWWWs..SHhssKsSKWLppNLpEMDp+VKpMLKLl-E...-ADSFA+RAEMYY++RPELIshVEEhYRuYRALAERYD	..........................................ppspWLtps..Lp-M-ppVKtM.lKLI..--.........-.....u......DSFA++AEMY..Yc+RPpLlshVE-hYRsYRALAERYD...............	0	16	88	125
+7597	PF07766	LETM1		LETM1-like protein	Fenech M, Wood V, Mistry J	anon	Pfam-B_2202 (release 14.0)	Family	Members of this family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen  ion exchange [3]. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.64	0.70	-5.36	13	760	2009-01-15 18:05:59	2004-07-28 11:08:40	8	13	347	1	502	777	35	218.00	28	44.32	CHANGED	KcsLhs+lhcElpHYacGh+LLhh-h+..lSsKllh+lhsGtp....LoRREppQLhRTsuDlFRLV.PFusFlIVPFhEhLLPlhlKLFP.sMLPSTFpopsc+p-....Kh+pplpsRh-hu+FLQcTlc-huhpscsphppttp....cFssFhp+lpsssc..sS....s-EIlchuKlFcD-h.sL..DsLoRsQLsuLC+hhpLpshGTsshLRaQL+h+l+pl+pDD+tIstE.GV-uLostELppACtuRGh+uhGlScEpL+-pLppWL-LpLppplPsoLLlLS	.................................................h....h.chhp.hpha..h....pGh.+LLhh...-..h+....hut...+lhh..+.h..h....t..G...t.................LoRR.Eppp..........L...h+................p.............htDlh+ll.Ph...hhlllP.F...h....ph....LLP.lh.l.+.h...FP..shL.PSTFpsppp...cp.c...................thp..p..hhth+h.....p..........h.t.p.h.l....pp.ph....ppht............t...t....t........t..........phtphh.....p.pl....ptstp......s...............pplh.t...htp.h..Fpsp....sL...cp...ls..p.........p.Lhshs+.......hh..........l.p....s.....h............s..s..s...h........L....Raplph+hp.lpt-D....ph.IthE.....G...l..p.s.......L...s......tELp.AChtRG.....h.psh..s.....h.......s..t.p..hcp.Lp.....................Wlplphp.ths...Llh......................................................................	0	164	274	405
+7598	PF07767	Nop53	P60;	Nop53 (60S ribosomal biogenesis)	Fenech M, Wood V, Mistry J	anon	Pfam-B_8778 (release 14.0)	Family	This nucleolar family of proteins are involved in 60S ribosomal biogenesis.  They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation [3]. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60) [1]. This protein has been found to interact with herpes simplex type 1 regulatory proteins [1].	24.90	24.90	25.30	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.38	0.70	-5.47	25	375	2009-01-15 18:05:59	2004-07-28 11:11:04	6	8	272	0	244	369	3	306.90	24	83.25	CHANGED	SRKuKKAWRKNlDls...-V-psL-chR.-EcIpGGs..luEKss--LFslDopuss.......pltptppp+hpKPLK..scpIL...ps+Splsulss++ppssps.............p+.+pp.lscc-htRLtplspcppstpsph.ssp................aDlWucpss.p...................thshsphshtpss.pslK.tPhplttss....t..lP.ulchscuGtSYNPohE-appLLppttccElctEK+cpchc+ppppthpths........h...t...psh.Esp....-s-scscs...---st..t.-u-h-....sh.stpc.sc+KT+sQRN+p++cKctc+ptc...hp+phKpcppplt+l+uItcclsp+ppphscppcpcp....pcsccpth+p++L.GKhch.-tslEVhLsDELssSLRpLKPEGNLLcDRF+oLQ	.......................................................................................................s+ptK+sWRp.hp.....-lpphhcp.p.pp.h.....hG...htph.sp.pLFhlD.t.pt.............................hh.h.h...+.L+...sp.ll...tppot...l.s....t.ht.t........................................p.t....pp..h.p...h.....th....tt..........pt...t........................................hDhWsptt..t..........................................t....h............h...t.......thp....s.phttps............................h..slphstsGtSYNPshpsapphlt.p.t...hph.....Ehpt.c.pp.phpc.......h....hht......................................................ttp.................ptttt.t............tppp.t......p.sthp..........h.t...ht...sc+...KT.ctpRp+.tct+....p.ttttt......t..pt..h+..tp........ppl..p.lctlttpl.tpct...tthttht.tpt............tptpttt......p.......ppL....G+h.........ph..t..sl-l.Ls-ELs......sS.LRpL.KP.pu.slhtDRh+sh...................................................................................	0	86	136	203
+7599	PF07768	PVL_ORF50		PVL ORF-50-like family	Fenech M	anon	Pfam-B_8834 (release 14.0)	Family	This is a family of sequences found in both bacteria and bacteriophages. This region is approximately 130 residues long and in some cases is found as part of the PVL (Panton-Valentine leukocidin) group of genes, which encode a member of the leukocidin group of bacterial toxins that kill leukocytes by creation of pores in the cell membrane [1]. PVL appears to be a virulence factor associated with a number of human diseases [2].	21.60	21.60	21.60	21.80	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.90	0.71	-4.10	6	423	2009-01-15 18:05:59	2004-07-28 11:12:33	6	1	235	0	5	197	0	113.60	54	91.85	CHANGED	IlplpsK.PhKaspaE...tElhcKpGIosGlVppRV+sGWchpEAl-APhGh+LsEY+EhphpctlcptphEREhtRcR..........R+EAEL+RK...KPHLFN.VPQKHPRG+Yssah..h.NphF.+Khpc	........................................IVpIpsK.PY+FocaE....ELIEpaGITsGMVuKRVK.c.GWcLcEAhcAPcGhRL..uEY+Ehhphc...hl...Ep.tchERchtR...cR.............++EA.ELRRK...KPHLFN.VPQKHsRs.Y..ah..h.NphF.hKhpc............................	1	3	3	5
+7600	PF07769	PsiF_repeat		psiF repeat	Fenech M	anon	Pfam-B_8872 (release 14.0)	Repeat	This region is approximately 35 residues long. It is found repeated in a number of putative phosphate starvation- inducible proteins expressed by various bacterial species. psiF (Swiss:Q7AH28) is known to be an example of such phosphate starvation-inducible proteins [1].	20.70	20.70	20.70	20.70	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.57	0.72	-4.41	35	1450	2009-01-15 18:05:59	2004-07-28 11:13:55	9	3	719	\N	184	570	34	34.50	64	64.33	CHANGED	A.ssQQpKMpsCNupAssKsLKGD-RKsFMSsCLp	............s.LTPQQQKMpsCNpQATsQuL....KGD-RKsFMSsCLK..	0	17	67	127
+7602	PF07771	TSGP1		Tick salivary peptide group 1	Fenech M	anon	Pfam-B_2333 (release 14.0)	Family	This contains a group of peptides derived from a salivary gland cDNA library of the tick Ixodes scapularis [1]. Also present are peptides from a related tick species, Ixodes  ricinus. They are characterised by a putative signal peptide indicative of secretion and conserved cysteine residues.	20.00	20.00	20.70	20.30	19.60	18.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.95	0.71	-4.23	8	125	2009-09-11 03:26:28	2004-07-28 11:18:23	6	2	12	0	13	126	0	108.80	37	87.82	CHANGED	MthTslTLVLVSLAFFuoAAAcsCpNGTRPAS-pNREGCDYYCWNssTsuWDcaFFtDGEsCFYNsGscGsCpsGcCHLsT..sSGsPocssDasspPo.......ptPKpKKKKspKsKKPK+poc.KD	.........................................thh.hhhsL.V.sl...AF...hs.......s..uAu.c....s.....Cpsus..R..P.uu.cpsR...-GCcYYCa.Ns.t..T.....suW-p.h.FF....s...sGEpCaYs.s...Gp.c..GhC....ps.....G...t....C...Hhss...........suusPs..-s.s.p.ss..sp.........p..............................................................................	1	13	13	13
+7604	PF07773	DUF1619		Protein of unknown function (DUF1619)	Fenech M	anon	Pfam-B_8790 (release 14.0)	Family	This is a family of sequences derived from hypothetical eukaryotic proteins. The region in question is approximately 330 residues long and has a cysteine rich amino-terminus.	20.90	20.90	22.10	21.20	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.56	0.70	-4.61	16	255	2009-01-15 18:05:59	2004-07-28 12:10:45	6	8	95	0	139	257	1	242.40	26	46.65	CHANGED	CsCDLohuhCDlNCCCDpDCsss.stphF.thCh.tshsss.....pphCsp.ppsppopshp..........hsphssshhClhpoNpp.............ssh.shhtpsssss........shsthsps.stsssssthYchGDPlhh..........t.pssuhhplPsshss.utCs....spsVtFLpshs.osCs......hsthp....th.hsphsshhllsssp...........sss.h.hslphshtpshsthlss........sphhs..spsptCsssVlplchphhassss.l.thplhhhtuplshps...tshltpcFplp...Fhpts.ts.ssshSGNsGYlsGpP	...............................................................................................CsCDLpsstCDlpCCCD..DCs......hpl....F...p..........C.sssht.ss..................p.hCst..phh.hs..s..................t.s......hhClp.ss.p...........................sh.t...hh....p.s.ss.shp...................s...h...t..t......t....ssshY.c.Gssl.s............................uhhp....hPtsh.hs.u.Cs..p...........ssPsu.F.......L........s.s..spCsh......t..............sLp.h...t...h....s.....lhth.t..................t.h..pl........hpphs..t.hht.............................................................t.phstsll.phpY.h.hs.....s...s........t.ltphslphh.spl.............s.t..............................lpQ..pF..lp............F...p...s.......................hSGsPGY.hGhP..............................................................................	1	43	51	85
+7605	PF07774	DUF1620		Protein of unknown function (DUF1620)	Fenech M	anon	Pfam-B_8944 (release 14.0)	Family	These sequences are mainly derived from predicted eukaryotic proteins. The region in question lies towards the C-terminus of these large proteins and is approximately 300 amino acid residues long.	20.70	20.70	25.40	23.40	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.37	0.70	-5.08	35	334	2009-01-15 18:05:59	2004-07-28 12:12:07	8	9	278	0	229	324	4	207.20	36	23.50	CHANGED	hsENWllYoYass.........shhphplsllELaEsppsssptsh..............tphoSh........ss.shstllspsalhs.p.tIpphulTpTcpGITsKplLhth.sosplstlP+.lLssRR......sppssss-.pcEth.hsYpshlshss.phhloHppplhshc....................pllosPotLESTollhuaGh..DlFhTR.lsPStsFDlLscsFsK.htLlhTlluLhlsshlspshsppKplpttW	............................................uENWll...YpYass..........................ps+c.clsllELYEusp.t.tspssh..........................SSh......................sps.hP.pVhpQ.oYlhP..p..sIsshtsTtTcpGITo+plLlsh.tostIlulP+..t.lLDPRR..........P..ptsot...........pp..pEEsl.lPYsP.l.lps..ct.hl..saspsV.tl+............................sIhouPo.tLESTsLVhAaGl..DlFhTR.lsPSppFDlLp................csFsh.hhlhhslhuLhhushlsp.hsppKtlpptW.................	0	81	130	191
+7606	PF07775	PaRep2b		PaRep2b protein	Fenech M	anon	Pfam-B_4098 (release 14.0)	Family	This is a family of proteins, expressed in the crenarchaeon Pyrobaculum aerophilum, whose members are variable in  length and level of conservation. The presence of numerous frameshifts and internal stop codons in multiple alignments are thought to indicate that most family members are no longer  functional [1]. 	19.20	19.20	20.10	20.00	19.10	18.70	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.70	0.70	-6.29	15	107	2009-01-15 18:05:59	2004-07-28 12:13:36	6	2	6	0	61	113	0	199.00	21	57.96	CHANGED	LcAlsPtLPtLacLRDALsEFADAF+sVTtEsl++KaGl-huYDVRNEpFFKKL-EllsMsE-YVY+NlsVERsPLDsSGphPKsVIRFKLs.GEElAHIslYWTGpcLpApFsGSREpAERLASII+ALGGcAEVKch.GstWhVpLTTDGIsAIRHsuWLsAVRuFV-ELac......KGLIuc-RY-pLl+-IEAGPNsVKaAGVEFSVhYc....t...s+pIhlcYpPpSEsoKNAAVsALKA+GL+EGVHFTVpc.Gu..YEIRVstE.YsKAlEsLspsGL+cGEaYul.s++RhIpVKs-pKDsllNALKsAGLtEG+cFss+.sG.YhIhITYDGLREIQRMALsGDhEAERFIRcLEDVL+RRaGpsAlpKLhEVLpPAREEGTlD.LPLsVhD-+GNllARVVDLKYEFVc........sspPVspCAGE-CRLRllVEYEs.uGER+QFKhEWYWtc.pcc+GpsTlTYYaEhAtsslKs-VEAAVLKALTG....KuKRGpVhLhAcpL-ALpRFKuL+DA.lDpWRsu+P	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	46	47	47
+7607	PF07776	zf-AD		Zinc-finger associated domain (zf-AD)  	Guo J, Finn RD	anon	Pfam-B_14442 (release 14.0)	Domain	The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold.  The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.03	0.72	-3.98	98	2455	2012-10-03 11:22:52	2004-08-16 09:21:17	10	977	74	1	1809	2536	0	74.80	20	13.71	CHANGED	hCRlCh......................pppsphhslhppt..........pst........plsphlpphhslplp........ts-shsp..h.lCpsChpplpphhpFcppspps.pphhpph	.......................................hCRlCh...................................pptph..hs.l..aptt............................................ttt.....................plsphl.p.p.h.s.s.lplp......................ps-..slPp......t.lCppChpp.lpph...h....p....F+ppshpspphlt..h.....................	0	336	502	1534
+7608	PF07777	MFMR		G-box binding protein MFMR	Fenech M, Bateman A	anon	Pfam-B_5000 (release 14.0)	Family	This region is found to the N-terminus of the Pfam:PF00170 transcription factor domain.  It is between 150 and 200 amino acids in length. The N-terminal half is rather rich in proline residues and has been termed the PRD (proline rich domain) [2], whereas the C-terminal half is more polar and has been called the MFMR (multifunctional mosaic region). It has been suggested that this family is composed of three sub-families called A, B and C [1], classified according to  motif composition. It has been suggested that some of these motifs may be involved in mediating protein-protein interactions [1]. The MFMR region contains a nuclear localisation signal in bZIP opaque and GBF-2 [2]. The MFMR also contains a transregulatory activity in TAF-1. The MFMR in CPRF-2 contains cytoplasmic retention signals [2].	20.50	20.50	21.70	20.80	17.60	18.10	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.75	0.71	-4.37	23	187	2009-01-15 18:05:59	2004-08-16 09:23:41	6	6	41	0	63	170	0	162.00	36	47.29	CHANGED	MGs.uE-spss.c....spPss...p.....s............psssssY.PDWuu.MQAYYus......s.PsaF.ssl.Auu.s.PHPYMWG.sQ.........MMPPY..GT.P..YsAhYP..GGlYA.HPuhP.us.s.s.h.........stss...sssshoh..Es..sKuopsK-+sshK+.KG.s.....sh.hottsspssKssu.usspshSp..........u-Sus..-GSS.pGSDuN.opsss	......................................................MGs.s-.sps.K..........pcssss..p................s......tsss..sa.PDWus.hQAY.s...................ss.saa.ssh..Auu.t.sHPYMWG..p.....................hhP.PY.Gs..P..Ys.AhYP...GulYA.HPuhs.s.......................s.........sssshuh..Es..uKsstsp-ps.hK+.Ks.......sh.hsttsspssKssusoussthSp.............................spSss..-uoS.-uSDtNopt..t............................................	0	6	35	50
+7609	PF07778	CENP-I	Mis6;	Mis6 	Wood V, Finn RD	anon	Pfam-B_17323 (release 13.0)	Family	Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis [1,2].	20.00	20.00	21.60	21.60	17.90	18.80	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.72	0.70	-6.31	5	194	2009-09-11 09:41:59	2004-08-16 09:25:22	6	6	139	\N	135	181	0	357.00	25	61.93	CHANGED	MSs.cts+Nopt..R..QsppS.QTsL.sW+httpssspKsh..cupu..LuDpcHssDQ...DuLppAlsYFEKusc+sSpsKcolLcKHLcTlEsVAacsGLsPEuIDlLLDVALSGK..FusAlsTRILKCLIPsotISEDSVVKuVSWLCVG..KCSusIQlLFLRWLIsMFDFID+KcQlspLYGlFFshLsD-sLCPYlCHLLYLLTKKENVKPFRlR+LLDLQuKMGM..QPHLQALLSLYKhFsP-LISlSLPsRKKsaFKNuDs.W+AALpAV+QRNpussP-Pp.+LhLGssss+SpKRKWNppSlIPAlsos+..h.sttK.MSh.D.husssSaPLEQLpSFPQLLpNIH+LEFPSQMuSVLsssLLLHYlNCs+DEslLLRLsYWLoQTLQEECsWhsssNsQcEcEFpsFLDhll+upCFLQEGF.SCEsFLYKSLPLWDGhsCRSQhLpLVoWIPhSoFSElKslLLDcLAQLFFTSolYFKCSlLpsLK-LLQNW.LpWLS.-lplpShosSPh	...................................................................................................................................................................pt...ht...h..ht.ltphAhppGl.sp.lp.Llplh..hp.p....hsp...ss.s.pll.K.sh.hP.s.p..h..lsppslhpslshLs.s.............KsS.shpshhh+WLlhh..a..c..hl.-....pp..p.lp.thY..uhhF.s.Lp..sl..p..lC+L......L.l..l............T+.+cp..................V....+s.......aRlptl....hpL......tph..G.....p..tL.uLLplaK.ahPpll...........sh...s..h...s.....th.t..h.F+p.c..Wptt.h.tlp....pp....p..........t...........s.......ht..........t..........s.tt...+..p.......h.lPshpo.p.......................................s.ppt.h..slEplpsh.phlpplcplE...hPsQhsuhLtsslh...+hl.hh...sp.h....Rh..Wltthhp-.................tt........t...p.tpp.h................hLphlhph.phh..pph..sh.tFhh.p.L.hWsG.p.ps.hltllpahPh.....s.pphh..hht.Ltthh.hsss.....phtllp.hptllppa..h.................h............................................................................................................................	0	27	59	102
+7610	PF07779	Cas1_AcylT		10 TM Acyl Transferase domain found in Cas1p	Anantharaman V	anon	Manual	Domain	Cas1p protein of Cryptococcus neoformans is required for the  synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence [1]. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase  superfamily [2]. This superfamily is comprised of members from the  OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family [2]. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity [2].	27.30	27.30	28.90	31.10	24.90	23.70	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.78	0.70	-6.03	8	235	2012-10-02 17:00:17	2004-08-17 10:03:26	7	11	127	0	174	248	4	389.60	33	62.91	CHANGED	-hhph............sDGTCCpshcssTslQtlshshlhlsh.hhhh...hhhhphs.thpspshhsshp..pp.ttt..tp............suhpslhsuLspLGLIMAYFYLCDRTshFMKENKaYochsFalPllYlhVLGLFasEso+.-TKVLNRDQTDEWKGWMQLVILIYHhoGAS+lLPIYMaIRVLVAuYLFhTGYGHFoaaWp+GDFG..hhRlsQVLFRLNFLoVlLChsMsRPYQFYYFVPLVSaWahVlYsTLAlsPplsupsspsN.h.ahhLLlKlsshhshITlLhhSpshFEclFslhPLctlFsl.cssl+EWWFRWpLDRYlVaaGMlaAhhaLthQ+tplhD-sptssLhSpp.ht..hlllullullsYhsashsCcsKh....pCNElHsYluhlPIluFllLRNIoGhLRSpYSoaFAWFG+ISLELFIsQYHIWLAADT+GlLVLIPGsPsL..........NllloTaIFVClSHEVuplTspLsphhVPpDtppsh+phh..hshFsus	..................................................................................................h..............................................................................................................................t.hh.uhsphuhlhhYaYhCD...................RsshahcppK.Ysc......Fh.h....h.h.h..lh....s...h.u.h............h.h.c..............p..........p..................p......p...............t..t..........h........LNRcQT-EWKGWMQ..........llhLhYHhh...uAsp.....lY.tIRl.hlAuYlahTGaGpFoaaah+.tD...Fu....................lhR..........hsphhaRLNFhsshhCl.shspsY.hYYhsPhhohah....hhlY.s.slulhsph...sptt................hhhhKlhshhhh........lhhl.h....s.........hF-hl....a......h....phhh........t.......h....p.......s.........p.........lpE.....WhFR.tLDRa.hhhhGMlhAh.........ha.t.......h.....p..c...h.................c..t.........tt................ht......................t....h...........hhhhu.l.hs...h....h.h.Yhh.a.t.........h...p.sKh....phNp.hHPah.ShlPIhs.........alhlRNhst.hRsh...shFA...WhG+loLEhal...QaHIW.....L.............t......u......s..s......+h..lLsl........l.P..s...shl.................Nhhlsohlalhluacl.phTs.Lt.hhls.p.p...................hhhh.........................	0	79	106	146
+7611	PF07780	Spb1_C		Spb1 C-terminal domain	Fenech M, Bateman A	anon	Pfam-B_5001 (release 14.0)	Domain	This presumed domain is found at the C-terminus of a family of FtsJ-like methyltransferases. Members of this family are involved in 60S ribosomal biogenesis, for example Swiss:P25582 [1].	25.00	25.00	27.40	25.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.54	0.70	-4.85	35	314	2009-01-15 18:05:59	2004-08-17 10:07:12	7	9	273	0	235	323	2	238.50	34	30.26	CHANGED	pssscc-s-hE.................h..ttt.tpttc...................................chh...........................sAEshuLuppls.sKKo+cDLID-uaNRauFpD.....cp...sLPcWFl-DEp+HsK.phPlTKEtstthKp+h+tlNARPIKKVtEAKuRKKhRuh+RLEKh+KKAssls-ss-hoE+-KucpIp+LhcKss+ppp+ppp......plVVA++s........spshsuRPpGs+G+aKhVDsRhKKDhRAhKRht...K....K	....................................................................................................................................................................................ttptpps.......t.-.................tttt.t.p.t...t.ptttt...tt...c..........................................phchh.......................................................ssEuhALuppls.ucKs+c.DllD.suaNR.YsF.pD..c-........sLP-WFl-DEp+H...p+.phP.lTKctstth+c+h+tlNARPIKKVtEAKARKKh+shp+LEKh+KKuphls-sschoE+-Kspplp+lh+K.As.pp.cp+pth......phVVA+ts........spt.hstRPpG..l+.G..+aKhVD..sRMKKDhRAt++ht+.t..............................	0	87	135	197
+7612	PF07781	Reovirus_Mu2		Reovirus minor core protein Mu-2	Moxon SJ	anon	Pfam-B_9308 (release 14.0)	Family	This family represents the Reovirus core protein Mu-2. Mu-2 is a microtubule associated protein and is thought to play a key role in the formation and structural organisation of reovirus inclusion bodies [1]. 	25.00	25.00	280.80	280.50	16.90	16.50	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.18	0.70	-13.19	0.70	-6.56	5	53	2009-01-15 18:05:59	2004-08-17 10:08:56	6	1	24	0	0	56	0	726.00	44	99.09	CHANGED	MAYIAV.PsltVuSRsTsLlsoIDuhsscsst-tpDVushDPoalLRQLEhhSuGhosuDllcALlH+cWh+poshsLLPs++pLL-YLLSNPSAsPDslDRopLKuhhhpK+hssD.........F+IpDaauPLIosSTuluThoRpLNAuplVYosTsKVlGARL+LaAPAKYYuuoLSsppppuIlPSoccltssP+uRlsVosFPSloTs+CFVLouVDt.ssPsh..sVcaIQLhYpRshuV+ARhLsD..PlAluchlscpuLKsphssPoDA..RAARLstlRsputosPsGlNsStlsVVDLphph.ssscuLtsVsRsh+LTlHuVPSCLLphL-ITluDc.YPIRpEoGMFssWFLlLTLhSDclTDuRT+puVhLpPuSsuscslsaVplsusVSsRspSVtussusalcuVGLsLPKGSFKSTMI+sLsuLpIsGspVM.ussVlDSD-VGDSLcPTFETA...lY-tLtuLDP..lDDllKlALuTDLlsp-ssloplasoFLcLssELLTPtARchYspposEGRoLTFAHADSEhLNANasu+LlRstIPYacEVNILlRPNRVGGsLFQVlLSYCYKMaATSssosPhGtLLKpLFsPWLcussLlusLsPscoSAsluWaIPuchhsssGWChC-D.taloas.IRuhPL-lSVLctacWuRa+AsIlV-co.....LVplGuDhRssthuVhassatPsVcLlophAsFTLss+YclpL...........sCusooGRsasAcNs+LsloosG	..........................MAYlAl.Psl.VsSRposhlshl-uhs.lcsth-h.sDVthhD.shlLcQl-hhssGhpssDlhcuLlH+sWh+pSlhsLLPs+ppLLEYhhSNP.S.uhPDslDRphLKth.......Kch.pD.........F+lpDaauPLIosoTShhThsphLNst.IVYoTTc+VlGARlpLauPtKYYsho..uhhpphsIl..scclhsVPpuRhhVGsFPShuTspC.VLouh-h.stPsh....hchIpLhYp+.hp.VpAphLsD..P.lsuhhlsp+pl+st..sPs-t..RAAR.htlphp..stsssptlssthlpV.VDlhhph.sstcuLhsspR.h+LThhuVPsClLphLslp.luDt.hsIRpEsGMFs.WFLlLThhSDtlpDsRsp.tlhlpPSSssspsl.plplTuhlst+s.slhsshhsh.lcsIGlshPKGSFKSThh+hLsulpIsGsp.lM.pssVlDSD-VGDsl-PTFEpA...lYcult.ulDs...-DlhKhshsoDLlsp-.hh.uplassFLtLsp-LLsPhARchYspphsEuRsLTFAHADSEhLNAsasu+LhRshIsYhpEhNlllRpsRlGGsLFQllLShCYKMaATSssspPhu.hL+tLhsPWLcst.LluphsPspoSt.luWaIPsphhhpsGWCsC-c..talsas.IRu..hslp.LphhsWupa+Apl.Vssp.....LV.lGtshRssthuVhhssphP.VclhsphAhFT.ht+YchpL...........pCspusGRs.tAhNh+Lhhpo..................................................................	0	0	0	0
+7613	PF07782	DC_STAMP		DC-STAMP-like protein	Fenech M	anon	Pfam-B_9122 (release 14.0)	Family	This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP, Swiss:Q9H295). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins [1]. It is thought to have seven putative transmembrane regions [1], two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC [1], but these are not conserved throughout the family.	25.00	25.00	26.90	26.90	24.50	23.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.94	0.71	-4.68	19	281	2009-01-15 18:05:59	2004-08-17 10:10:02	8	6	81	0	182	260	0	173.30	25	29.66	CHANGED	F-NhYlTctFhph-pcccchsttslLPLpppEcpphlplsphphotp..Ehhplhhphh.lhlphlthshhlhlDahlapllshlpp..........h...phps.ttlplpl.sGsuhhuclh............cphhpsFpshp...phshphss..pcC.lPpPph.shtshlhlslLhLhshhllhlpsYshRlR+lIsu.FYPpcE+cRlhaLa	......................................a-NlYITp.FhphDtpcpphtp.s.lLPLpptE..p.p..phl..spht.l.stp..Eh.hp.h.hhthh.hhhhhhhhhlhshlDahlahllphhpp.............................................php.s..hlplpl...tGtuhhuplh.............+phh.t.shsh.p...phs.hphss...pC.LspP..p..stpta.hhl..sllhhlhhhlslhpsashRLR+.llsu.a....aPppEc.cRlhaLa...............................................................	0	45	59	112
+7615	PF07784	DUF1622		Protein of unknown function (DUF1622)	Fenech M	anon	Pfam-B_9062 (release 14.0)	Family	This is a family of 14 highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.	19.90	19.90	20.50	20.50	18.60	19.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.37	0.72	-4.33	51	422	2009-01-15 18:05:59	2004-08-17 10:21:47	6	2	358	0	127	289	25	80.30	35	64.72	CHANGED	Gslhuhh.......phlttthtpp.......stsa.....p.plRhplGphllLGLEFhlAADIlpTsl.sPohp-lhhLusIllIRThLuYFLs+El	..........................Ghhhuhhphlp..hppp.......spth.....p.tlRthLGsalLLuLEhLluADIlcTll..pP.Thp-lhhLuslllIRTlLSaFLppEI......	0	44	91	112
+7616	PF07785	DUF1623		Protein of unknown function (DUF1623)	Fenech M	anon	Pfam-B_9100 (release 14.0)	Family	The members of this family are all derived from  relatively short hypothetical proteins thought to  be expressed by various Nucleopolyhedroviruses.	25.00	25.00	61.90	61.60	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.17	0.72	-4.03	13	31	2009-01-15 18:05:59	2004-08-17 10:24:15	6	1	30	0	0	26	0	87.60	39	88.90	CHANGED	LoAaVLhVsNs.sh...p.p.hYhthLc+asVlDulMCs.NGDCLAVslossshhsp...............p.ppLcll-...pas.psl-hLh-KIYsIV-hYN	.LhsaVlhlsNs..ch...p.p.IY.pYLp+asVlDulMCs.NGDCLAVsVossshlpp.....................psLcll-...pts.psl-hLp-KlasIlEhYs	0	0	0	0
+7617	PF07786	DUF1624		Protein of unknown function (DUF1624)	Fenech M	anon	Pfam-B_9180 (release 14.0)	Family	These sequences are found in hypothetical proteins of unknown function expressed by bacterial and  archaeal species. The region in question is approximately 230 residues long.	20.60	6.20	20.60	6.20	20.50	6.10	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.62	0.70	-5.01	49	1276	2012-10-02 17:00:17	2004-08-17 10:26:21	7	9	944	0	477	1471	482	201.10	17	57.55	CHANGED	RhhtlDhhRGlAllhMlhaHFsaDLpaFGhhshsht.sshathhup.hlAshFlhluGlSLsluhspshph..........ppah+RhhplhuhAhlIossTa....l..hhP.pual.hFG..................ILHhIu....luslluhhF..h+hshhshhhhuhhhlhh........shhhtt...................hhsss.....hLhWlG....lhs...tsh..ho.DYhPlhPWhGlhLhGlshuphhh.p...tpht...hst.hhhtsLsh.l..GR+SLhl..YLlHQP	...........................................................................RlhslDhhRGls.llhMll......s...p....h......h.....h.................h..........t......................h..h.....h...............h.........................t.....h............................................h.......h....h..h....h............sp....h...........s....h....sh..Fl....hls..G..h..ohh..l...h..ht.p.t.th................................................tth.h..p....R..s..l.....h...l.....h...h...h..u..h..h.....l.s.h.h.sh.................h......h.hs......ph....l....hh...s...................................................................................................l.Lpt.l..u....l.s....h..l...l.s.h....h....h............hp.h......h....h....h....h.h..h.h....u..h.h.h..hh.h..........................hh.....................................................................hh.t.................h.......hh........h.......................................s..............h........sh.h.......s...hh.....sh.hhhGhhhu..h.h................................................................................................................h..h..................................................................................................................................................................................................................................	0	161	323	402
+7618	PF07787	DUF1625		Protein of unknown function (DUF1625)	Fenech M	anon	Pfam-B_8907 (release 14.0)	Family	Sequences making up this family are derived from  hypothetical proteins expressed by both prokaryotic and eukaryotic species. The region in question is  approximately 250 residues long.	20.30	20.30	20.30	21.00	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.49	0.70	-5.13	22	173	2009-09-11 05:28:20	2004-08-17 10:32:38	7	4	130	0	114	183	5	235.90	27	61.61	CHANGED	MYQWVEppppcp.pp.ss..p....oYpYsppWpsphlsSppF.t.pGHpNPss.h.lpupshhs.pV+lGsahLupslhpplss.hcslshss................pssttphphpsshhYhsps.stpPpl.....................GDlRlpFphs............ss.sollucQpss......plhPapopss............................................ppl..hlh.GphoscclFp...pttppsshhTWhhR..hsGalLhFlG..hhhhhs.lthLsshlPllts.............lsshshhlhu..hhluhslsLhsIAhuWlhYRP	...........................................................................MYQWlEppppcphpp.stt.p...........ppYpYsp-Wpschls..SppF..ppthGHp............NPs.....t..hslcSh..shhAstVplGt.ahLusslhcchss..hptls.h..sp...........................................ps.pssl.ph....psshhYaups...stpPpl.............................................................GDlRlpFphu...............ss.ph.soVl..u..cQ.p..us........plhP.ap..opsG.....................................................pplh.ll..t..Gp...h..oscchFp...ppp...pssshhTWh.hR...hhGahhhFh.G..hthhh....ph....lhhlh...s...hhPh.hts................lsshshhh....hs...hhhuhslslhsluhuWlhaRP............................................................................................................................	0	49	66	89
+7619	PF07788	DUF1626		Protein of unknown function (DUF1626)	Fenech M, Sammut SJ	anon	Pfam-B_9705 (release 14.0)	Family	This is a family consisting of sequences from hypothetical proteins of unknown function expressed by certain species of archaebacteria. One member (Swiss:Q9YCN7) is thought to be similar to tropomyosin [1].	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.14	0.72	-4.19	18	128	2012-10-11 20:44:44	2004-08-17 10:41:17	6	6	56	0	61	129	12	70.70	35	27.66	CHANGED	ScVElDlllKDGplIllEIpSSlpRGDlhhlcRKs-LYE+scuhKhs+llllTPaI--R....s+thAcclGIc	....pplElDl.ll+sGhhlllElKSulc+uDl..h....htRKschYE+.hps++ss+l.llloPhlcc+....uhthAccLGI-..............	0	26	36	45
+7620	PF07789	DUF1627		Protein of unknown function (DUF1627)	Fenech M	anon	Pfam-B_9837 (release 14.0)	Family	This is a group of sequences found in hypothetical proteins predicted to be expressed in a number of  bacterial species. The region in question is  approximately 150 amino acid residues long.	25.00	25.00	27.80	27.10	24.10	23.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-4.68	4	472	2009-01-15 18:05:59	2004-08-17 12:03:29	7	1	171	0	4	267	0	143.60	65	64.12	CHANGED	IEQ+GPQTADELAshFGsTSRKVASTLAMAISKGRLIRVNQsGKFRYCIPGsNLPAEPKAASVocsDGKAFPQPsGsALPVtEAATQE-IKTEoVAslVQs.PSFTcppsDtLlhPSL+hANhtLRRAKspVQKWERVCAALRELNKpRDIlRpI	...........................................ItQcGspTs-ELAshFGlo..oRKVASoLAhshupGRLhRVNQsGKFRYCh...P...G...ssLPAEP.KAAsVs..EoDGKAFPQPA.GsALPVpEAAT.QE-IKTEoVA-hVQshPSFT..cs.ps..DsLILPSLHhANRELRRAKupVQKWERVCAALRELNKHRDIlRpI.......................................	0	1	1	2
+7621	PF07790	DUF1628		Protein of unknown function (DUF1628)	Fenech M	anon	Pfam-B_5107 (release 14.0)	Family	The sequences making up this family are derived from hypothetical proteins of unknown function  expressed by various archaeal species. The region  in question is approximately 160 residues long.	24.20	24.20	24.30	24.60	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.96	0.72	-3.23	48	295	2009-01-15 18:05:59	2004-08-17 13:02:07	6	14	62	0	237	307	97	81.90	25	31.71	CHANGED	cAVSPVIGVlLMlulTVIlAAlluuFlhuh....ssspssPp.ssl...........p.p...hssssst...............lplpHpGG-slss...pslplh...lsssss	.........puVSPVlGVlLM...lulTVIl.AAllus.as.huh.....sss.sppsPp..ssl.......................................php.........hssssst....................ltlpa.tG.G.-.s.lsh...pplplhh.....s....................................................................................	0	40	200	223
+7622	PF07791	DUF1629		Protein of unknown function (DUF1629)	Fenech M	anon	Pfam-B_9012 (release 14.0)	Family	This family consists of sequences from hypothetical proteins thought to be expressed by two members of the Xanthomonas genus. The region in question is 125 amino acid residues long.	22.10	22.10	23.50	24.80	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.58	0.71	-4.24	13	56	2009-01-15 18:05:59	2004-08-17 13:46:31	6	1	29	0	16	57	1	119.60	48	57.33	CHANGED	ctGEFahLcsDhcusGsspGVVFENc+pLLoPPRLILRPc-GGFPsLREpP+LsY-PspGs.PcDLEuGFSGYWLVSERL+pVhtuVDP-AFAFA-sDaRLADGopGPRaaLCDVVRpLDALDE	.....................................GpFahlpssh.tst.spGV.FpN.cpLlsPsRlILpP.c.pGGFP..sL+EpP+LlYcPscGs.P.cDLEsGFSGYWLVSERL+pVhpsVDPcAFAFA-sDaRLAD.G.o.tGPcaaLCDVVRpl.DALDE.	0	2	5	8
+7623	PF07792	Afi1	DUF1630;	Docking domain of Afi1 for Arf3 in vesicle trafficking	Fenech M	anon	Pfam-B_9160 (release 14.0)	Domain	This domain occurs at the N-terminal of Afi1, an Arf3p-interacting protein, is a protein necessary for vesicle trafficking in yeast. This domain is the interacting region of the protein which binds to Arf3, the highly conserved small GTPases (ADP-ribosylation factors). Afi1 is distributed asymmetrically at the plasma membrane and is required for polarized distribution of Arf3 but not of an Arf3 guanine nucleotide-exchange factor, Yel1p. However, Afi1 is not required for targeting of Arf3 or Yel1p to the plasma membrane. Afi1 functions as an Arf3 polarization-specific adapter and participates in development of polarity. Although Arf3 is the homologue of human Arf6 it does not function in the same way, not being necessary for endocytosis or for mating factor receptor internalization. In the S phase, however, it is concentrated at the plasma membrane of the emerging bud. Because of its polarized localisation and its critical function in the normal budding pattern of yeast, Arf3 is probably a regulator of vesicle trafficking, which is important for polarized growth.	25.50	25.50	26.00	25.50	24.90	25.20	hmmbuild  --amino -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.76	0.71	-4.18	31	156	2012-10-02 14:18:06	2004-08-17 15:51:17	7	6	144	0	117	210	0	149.80	36	19.68	CHANGED	pV-YILlApFDlD+GPlhcHQYPssl.sG..............sEphLAcLMLPDpsHsR.sp...DaTlFhLacss.spt.p...........ttt.......................pt.t......................................p.....tt....s.hahlsllpsptDpshcRGuhlKuhAlsTphshlaha+..sllhhsL-	............................................pVEYILlApFDlD+GPhhcHQYPssIsG...................................DEphLAE.......LMLPDpsHhRsp.....DWTlFa.La+sssspptp.............................t............................................p..................................................................................................sppptpsscs.....sshhYllNlVs.sppDpos+RGAhlKuhAIsTphsahplaKPlLllsL...............................................................................................................	0	42	72	103
+7624	PF07793	DUF1631		Protein of unknown function (DUF1631)	Fenech M	anon	Pfam-B_9170 (release 14.0)	Family	The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned  is approximately 440 amino acid residues in length.	19.70	19.70	19.70	19.80	17.50	19.30	hmmbuild  -o /dev/null HMM SEED	730	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.13	0.70	-6.40	36	372	2009-01-15 18:05:59	2004-08-18 12:44:36	6	9	187	0	125	418	96	617.90	21	89.36	CHANGED	ssptpsst.....sphPslLhpl+-pstppLtphLpshF-ssDDsLF-hA-+Atss.p-QshaF-AMR-LRh+RcslppsFhppltpuFss.Lspspssss..shs...hs.ssLoLVppc-LEcplAlcsMls+spschstsLtpLstRLshLh.sshplppcsNPLuPptLCpsFhcAs.psLslsl+s+LlllKLFERhVlsplsplYscANplLlpsGVLPcLp.s....................................hppspsss.........sssptsssssssssspsuss.ttttt.......................................pshFs....tLppLLtpsRssttsst.ssssss............................tslssp-LhphLupLQ...........t.ssshsssp.......hslpp.lppLLpphp..spsGpppslupsD-DlINLVuMLF-aIL-DcsLsssl+ALIuRLQIPlLKVAlhD+sFFs+ssHPAR+LLNplApAuhGWsspss.htcDsLhp+lpplVpRlLs-FscDsulFs-Lhp-FptFhpp-cRRs-llEpRsp-AEcG+s+tctA+pplpptLpp+ltsps.LPpsVhplLppuWocVLhLshL+cGcpS.cWppulplhDcLlaslp.pp.pspsppplhphlPsLLcsLRpGLppl.uacshpssphhppLcphthpshps........................................................................................t.st.stpssstspss-clsssttppsttttt....................stppphlpplcpLclGoWlEhtccc.tchhRsKLuuhl.csos+alFVNRpGhKVtEtotpsLAhthppGpl+lL..Dcu.hLFDRAL-uVlssLR	..................................................................................................s..................h...t.hht.hh..ht.hh.thhtth........tpt....Lhp.upputss...pt.h...hts....h....ptl.c.....pt....tth..t.thhtth.pthtt....h.t.t....t................t.ttL......sLltpppl-pplhlpthstth.pp.t..L.t.Lp.tRlshlh.......thttpp.PhtPthlsthhhpsh.tth.s.lt.p..sphhlhchhcp.lhtt.hsthYtphsphLhttGl.hP.t.h...................................................................................t....t.t..................t...t.....t.......s..............................................................................................t.hht.....tlpthht....t...htt............................................................................h.s.tttlhp.h.Ls.tlQ...............s...tt....................h.tt..htp.llpt..........tp.t..tthls..-pss.....ls...........lluhlFp.lhp-tplsssh+shlu+LplPh.l.+.l.AlhD.pF.FsptpHPARcLLsplupsshuhss.pss...t.p...ptLhtc..lpphVpp...lhp.pap.p.s..slFt.p...h.t-ht.t.a...h....p..........p....t.tpc...sph.hpp+hhc.stc.upt+hph....Ac.....p....tstttlpp.....hh.t.st.........s....lPph...l.phLppsWtcllhh.sh.l.+..p....G......tpu....thpt..h............h..t.hhspLlhshp.tt.......tttt.tl.t.....h.stLhpt..lppultph...u.hs..tttthhppLpp..hhhtshtt.....................................................................................................................................................................................................................................................t.........t...hh.pp.hs....ttt..................................................tpthh..t.h.cplthGsWl.-h.....ppp..tphhps+Lshhs...ssphlF...ls.ppG..h+h.h.h...shttLAh.hpt..Gthphh....ppt...lh-cAhpssltt............................................................................................................	1	33	80	108
+7625	PF07794	DUF1633		Protein of unknown function (DUF1633)	Fenech M	anon	Pfam-B_9750 (release 14.0)	Family	This family contains sequences derived from a group of hypothetical proteins expressed  by Arabidopsis thaliana. These sequences are  highly similar and the region concerned is  about 100 residues long.	20.40	20.40	34.20	29.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	790	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.40	0.70	-6.58	2	28	2009-01-15 18:05:59	2004-08-18 14:02:52	6	5	2	0	0	28	1	198.90	20	84.20	CHANGED	MpRLFSAPHLTsQIRRGEEISsISKIVVMMA.LNNFP.LH.hSRQLTpLs............................................SDh-DSQNKSNHSYGDssSSS..Rst.......+RVITLGGMGPIRpPSTRsDKPKKKKAsKQtGuhPMTNsDL.................Vs.cRtstVslpl+.hLpc.................P.L+L.pNVS......sG..shYsshhtcptlhhPhPAu..........Rs+-V...............sLSthcLt..hLLhpG......................................pschuTFsRDR.VsALslsPAsPsIs.PsAQ.DPlEEVPpl..hPpA.h.h...ls.sSsSTSp........Cso..........pARAsDLSAsVsAARsoLAsSpspASsSHPSLPtsN.......................................susstAAVul...................................uAsN+.......................LlthhctR.sQVP..............oupphp.GcphhRc.sspltssp-REVp.tAc.....h.RLKhELSTSKDLEKGYAEKIthME.EFtGLpADKQhARsQIHRLpp++-ELSK+VhDLTS.AQGspKAVHDAKVELAAuY.KLLuGIK-KWVsKKEaTVLEuQAAEVESNLALIDQIsKAAlDLTlEKPRhQAElDDlEARCp.KEVSDFTLSKLDlPcVSEh.VVRPhsVDEQGTPIGLDEFGSNKDsFPtGLt-ssGTVFAhPAGtS+E	......................................h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+7626	PF07795	DUF1635		Protein of unknown function (DUF1635)	Fenech M	anon	Pfam-B_9707 (release 14.0)	Family	The members of this family include sequences that are parts of hypothetical proteins expressed by plant species. The region in question is about 170 amino acids long.	21.40	21.40	22.20	22.20	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.27	0.70	-11.66	0.70	-4.96	5	89	2009-01-15 18:05:59	2004-08-18 14:04:57	6	7	23	0	64	90	0	190.00	30	60.51	CHANGED	cThEELRQoLlYTThELEQTKMhAsEElRp+DEQlhpLcDLLsKTlKERDEApE+hp+LLhcs..L.Qpp......................pDEQlpPNp.pLspsNSFSSSDsE...ESIsSSp.psh................-PsspppLcclsss-hLh..ll.-KsLPEKGKLLQAVlKAGPLLQTLLLAGPLPQWRHPPP.LcS..FEIPPVo.....ls.tCP.hossGCG.NFN+KRVa.luDtShsETKYQR.LLc	........................................................h-EL+ppLhhsohEL-thp..Ap-Eh++pcpplhpLhcLLptshpERDEApcphppLh..htt..h.t.t.................................................pspp.......tp....pp...u..hs..s.Sssp.....pshsSs....h........................................t..st.t.......t............t...phh....hs..t+sLPpKG+LLpAVhcAGPLLQTLLlAG...........PLPpWRpPPP.hp..s..hplPsh......................................................................................................t...................................................	0	12	47	56
+7627	PF07796	DUF1638		Protein of unknown function (DUF1638)	Fenech M	anon	Pfam-B_6091 (release 14.0) & Pfam-B_3149 (release 23.0)	Family	This family contains sequences covering an approximately 270 amino acid stretch of a group of hypothetical proteins.\	  These proteins are expressed by archaeal species of the Methanosarcina genus.	20.40	20.40	22.10	21.40	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.06	0.71	-4.61	55	232	2009-09-11 07:42:39	2004-08-18 14:25:11	6	8	168	0	105	231	180	166.10	23	67.84	CHANGED	phLsu.tLHstP-clpstlppslpchp...........sth-pIhlsYus..CGsu.....Gtlppph..schG.........lhh........htuscChuhhh...Gssphttch....schssFYLTshhscpa-s..............hhhcshGhDcpspLc....phhaup.Yp+llals..........psc..............-.thppcscchAsplGLsapch.sshGsLptslpsh	.............................hLsstLHsp.P..-clpptlpptlcphp............th-p...IllsYGt..CGsu.....Ghlspthp..t.........lhh............psscChshhh...Gspphttp......pchssaa..LTs....hhhcpacs...................hhhcthGh-ct.splh.....chhaspYpcllhls........ppc......................-..htppscchAchhslshphh.sshs.Lpphlt.................................................................................................	1	44	83	89
+7628	PF07797	DUF1639		Protein of unknown function (DUF1639)	Fenech M	anon	Pfam-B_6036 (release 14.0)	Family	This approximately 50 residue region is found in a  number of sequences derived from hypothetical plant proteins. This region features a highly basic 5 amino-acid stretch towards its centre.	22.20	22.20	22.20	23.30	20.90	21.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.55	0.72	-4.57	20	205	2009-01-15 18:05:59	2004-08-18 14:57:55	9	6	19	0	117	191	0	49.90	50	19.35	CHANGED	LS+cEIEEDFhAMpGs+PPRRPKKRsKsVQKpLD...............hl.PGhhL..sclos-pY	.LSp+EhEEDFhAhpG.sK.PpRPKKRsKhVQ+pLs........................hlhPGhWL..s-lot-pY...................................	0	14	66	95
+7629	PF07798	DUF1640		Protein of unknown function (DUF1640)	Fenech M	anon	Pfam-B_6194 (release 14.0)	Family	This family consists of sequences derived from  hypothetical eukaryotic proteins. A region approximately 100 residues in length is featured. 	24.20	24.20	24.20	24.40	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.04	0.71	-4.23	24	513	2009-09-11 19:38:48	2004-08-18 16:04:56	6	13	255	0	324	490	8	162.70	26	59.06	CHANGED	hFDTpthVp.pL.Ecs...............GFsppQAEslspslscllpsulpplspshVo+tphpp.........sthpQcschucl+s-lh.......................p...............h-+oEFsslpsEpE+l+sDLc+L+s+L+-Els+spAuh+LDLNLEKu............RlR-Ehupp-hK..................lp-hss+IDpElusL+splEosKhpslpaLhGsssushAlhLuahRlhh	..................................................FDThthVp.pL.c.pt.....................................G.FsppQApslhpslpp...llpss.....l.pt...l.....t.p.s.....h.ls.+.tc.hcp......................tthp.psshuc..l+s-l.........................................................................ccsch...sth+sppc.+lpt-lpplp....p...cLpp.E.l.sc.hps...sh+.LDhNhc+u..................cl+-..stp-hc...........................l.p-hpp+I....-p........-.l.s.s....l+tt....lE....s......hKhp....sh.p.a.h....h..u.h.hs.hhslhhuhhh..........................................	0	78	163	247
+7630	PF07799	DUF1643		Protein of unknown function (DUF1643)	Fenech M	anon	Pfam-B_9851 (release 14.0)	Family	The members of this family are all sequences found within hypothetical proteins expressed  by various bacterial species. The region  concerned is approximately 150 residues long.	20.20	20.20	20.40	20.50	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.87	0.71	-4.47	57	556	2009-01-15 18:05:59	2004-08-18 16:06:40	7	5	475	0	91	385	369	133.70	33	76.28	CHANGED	RYhLpRpW.........s..tsttpllFlhLNPSpAsttpsDPTlcRh.phA.+sh.GaGuhhlsNlFAhRuTsPpsLpp............ssDPlG..sc.NDthlhchsp.hu....spllsAW.GspGt....hhsRs....ppVhchLpst.............lhpLGlo+sGp.PcHPL	...................RYhLp+pW.........s....tpc.sshhIsh.P...shs.....s....s.....hp..DhTsth.lhsh.............h.....ps.....................saG...ulhllNLFu.hp.T.Pc.sLc.c...............hp.c.Phs.....pc..sDhplhc.sls..cu.............-pVlhAW.Gs....huc.........hhpRs......ppV.h.chLcsp...................tttlhp.l.h........s.tssc..hHPL.......................................................	0	21	51	76
+7631	PF07800	DUF1644		Protein of unknown function (DUF1644)	Fenech M	anon	Pfam-B_5078 (release 14.0)	Family	This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.	25.00	25.00	26.00	31.70	24.50	23.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.89	0.71	-11.18	0.71	-4.38	18	198	2009-01-15 18:05:59	2004-08-18 16:09:58	7	4	23	0	117	186	0	146.10	44	52.08	CHANGED	-DspCPlChEaPHNAVLLhCSSacKGCRPYMCsTStRHSNCL-QF++uhsctts.sp......................................................................................t.pppc..cLsCPLCRGcVpGWpVVcp.ARpaLNpK+RoC.p-sCsFsGoYp-L+KHs+pcHPsu+Ps-lDPscppcWcpLEpcp-htDllS	................................................cspCslCh-hPHNAVLLhCSSacKGCRPahCsTshp+SNCL-..pa+puhsp.t..........................................................................................................................pppp..pLtCPLCRGpVpGWhll.c..ARpaLNtKpRsC.p-sCsFsGsYpEL+KHs+pcHPpu+PpclDPs+ptcWcphEppp-htDllS...................................................	0	18	64	91
+7632	PF07801	DUF1647		Protein of unknown function (DUF1647)	Fenech M, Pollington J	anon	Pfam-B_5249 (release 14.0)	Family	The sequences making up this family are all derived from hypothetical proteins expressed by C. elegans. The region in question is approximately 160 amino acids long. The GO annotation for this protein indicates the protein to be involved in nematode larval development and to have a positive regulation on growth rate.	20.80	20.80	20.80	21.60	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.66	0.71	-4.69	15	96	2009-01-15 18:05:59	2004-08-18 16:22:08	6	6	28	0	90	84	29	119.60	29	31.81	CHANGED	CtChSspoGKoYsFCYpsPpNssSIGKKFsCuhLsTLEcLsLlspss.phlsLssshcNpsslVFVSATS-DHhs.uhpShpSlR+aYPppKaILYuLsLocs.IppLscp.pNlEhRtFNTotYPcYVsNWhcY+FKPLllA	..........................................................Y...ps.t.hGtp..FsC.hlthh-pht..............lh...........t..t....h.ph....pp..p.spppls.hVSssSssHhtthhp.hpslppahPsp+hllYuLslspt.lpp..lt..p................p.sshchRpFshotYPpaVp...shhpYpaKslllA...........................................	1	34	41	88
+7633	PF07802	GCK		GCK domain	Fenech M	anon	Pfam-B_8992 (release 14.0)	Domain	This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as Pfam:PF00071) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family (such as Swiss:Q9LMF3); this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerisation.	23.40	23.40	23.40	23.40	22.10	23.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.78	0.72	-3.85	8	81	2009-01-15 18:05:59	2004-08-18 16:43:26	6	6	28	0	64	77	3	69.50	36	36.18	CHANGED	GECtFCpFMKGGuCKEuFlAW.EcCs.-tAccsccpDhVT+CtElpuphK+CMcsHuDYYpPlLAuEKsucs+hcKEL	................-ptashFMKuGuCK-sFhAW.-cCs.pts...pt.ptp..shhpcCt-shstLc+CMc.AHuDY..YpPlLsspcshtpph.tt........................	0	16	26	34
+7634	PF07803	GSG-1		GSG1-like protein	Fenech M	anon	Pfam-B_9727 (release 14.0)	Family	This family contains sequences bearing similarity to a region of GSG1 (Swiss:Q9Z1H7), a protein specifically expressed in testicular germ cells [1]. It is possible that overexpression of the human  homolog may be involved in tumourigenesis of human testicular germ cell tumours [1]. The region in question  has four highly-conserved cysteine residues.	19.50	19.50	19.90	19.90	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.67	0.71	-4.50	8	150	2012-10-03 00:20:40	2004-08-18 16:56:19	6	3	42	0	77	136	0	118.40	46	41.34	CHANGED	+psR+sRuLLSlsLNhLALhFSsoAhlToYWCpGTQKVPKPhC.ot...s+ppNChshssssss...................sP...............ssVpYsWETGDDRFlFRpFHTGlWhSCEEslassuc+CR........SFI...cLuPsSp+G	..........ptpRshLolhLshLALshSsoAllooYWC.GTQKVPKPLC..up...sttspChchsss.su...t.ss................sp..........................psVpYsWETGDDRFhFRtFHoGhWhSCEEsl..c..p.sG..E+CR........SFl...-LsPstcp.u......................................	0	3	12	41
+7635	PF07804	HipA_C		HipA-like C-terminal domain	Fenech M	anon	Pfam-B_8632 (release 14.0)	Domain	The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis [1]. When expressed alone, it is toxic to bacterial  cells [1], but it is usually tightly associated with  HipB [2], and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with  cell division genes or their products [2].	24.00	24.00	24.00	24.10	23.80	23.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.01	0.72	-3.86	175	2174	2009-09-13 11:39:15	2004-08-18 17:00:02	7	16	1315	18	624	1916	261	82.00	26	20.24	CHANGED	Rlthpshsslhshsstp......................suat.plhphl............pp..hst............ttshpchhcphlFNhlluNsDsHsKNauhlhs....ss.s...h.pLuPhYD	........................................................Rl..pshsph..hshsst......p..................suht.pl.hphl....................tt...hs.t.s..................htch.tp.h.h.c.t.h.lFshLluNsDsHsKNaShhhp.....ss.s..................a..cLuPhYD...........	0	159	359	505
+7636	PF07805	HipA_N		HipA-like N-terminal domain	Fenech M	anon	Pfam-B_8632 (release 14.0)	Domain	The members of this family are similar to a region close to the N-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis [1]. When expressed alone, it is toxic to bacterial  cells [1], but it is usually tightly associated with  HipB [2], and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with  cell division genes or their products [2].	21.00	21.00	21.30	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.68	0.72	-3.76	170	2004	2009-01-15 18:05:59	2004-08-18 17:04:41	7	15	1218	8	598	1762	241	83.10	28	20.04	CHANGED	SluGspsKhslhh.............................ssssspaIlKhss.sp............h.shstsEhhshp.lAp.thGl.sss..pspl....hphss................ptshhlcRFDR	........................SluGsp.Khslhh.t...........................tth.h...s...s..s.s.sspaIlKhsh.sp.............s.htshspsEahshp.lAp...th..Gl...sss...pspl...hp.hss.................tpslhlcRFDR...................	1	152	346	484
+7637	PF07806	Nod_GRP		Nodule-specific GRP repeat	Fenech M	anon	Pfam-B_8942 (release 14.0)	Repeat	The region featured in this family is found repeated in a number of plant proteins, some of which are expressed specifically in nodules formed during symbiotic interactions with certain bacterial species [1]. Some of these proteins are also termed glycine-rich proteins (GRPs), due to the presence of a glycine-rich C-terminal region in their structures [1]. Bacterial infection is required for the induction of nodule-specific GRP genes, and it is thought that nodule-specific GRPs may play non-redundant roles required at specific stages of nodule development [1]. Members of this group of proteins may be cytosolic, whereas others are thought to be membrane-associated [2].	25.00	25.00	49.20	35.60	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.09	0.72	-4.34	10	36	2009-01-15 18:05:59	2004-08-18 17:16:57	6	5	5	0	0	36	0	36.80	65	52.23	CHANGED	Gss+ESKTKhGhDGWRDWGGSFWp.DscENNGGG-KEGG	GVs+ESKTKlGhDGWRDWGGSFW-stcENNGGucKEGG.	0	0	0	0
+7638	PF07807	RED_C		RED-like protein C-terminal region	Fenech M	anon	Pfam-B_9789 (release 14.0)	Family	This family contains sequences that are similar to the  C-terminal region of Red protein (Swiss:Q13123). This and  related proteins are thought to be localised to the nucleus,  and contain a RED repeat which consists of a number of RE and  RD sequence elements [1]. The region in question has several  conserved NLS sequences [1]. The function of Red protein is unknown,  but efficient sequestration to nuclear bodies suggests that its  expression may be tightly regulated or that the protein self-aggregates extremely efficiently [1].	21.50	21.50	25.20	24.60	20.50	16.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.70	0.71	-3.91	7	152	2009-01-15 18:05:59	2004-08-18 17:18:46	6	11	110	0	95	143	0	113.50	59	20.48	CHANGED	YuECYPGh.E..cthsDSD-EsDaSKMDhGsK.KGsltRWDF-TpEEYucYMpsKEALPKAAFQaGVKMp-.GRKTR+.pt.+s-KtcLDR-hp+IspIlp++K.htcDGu..........sssK+sKa	.....................YAECYPuh...-.....D.hhsDSD-E...VDYS...KMD....G...N.......K..KGPLGRWDFDTpEEYS-YMssKEALPKAAFQ..................YGlKMu-.GR.K.T....R+....hp..E.......p.......N-KA.....ELDRpW+KIssIlpKRK..h-t.D..Gs..................p.K..........................	0	30	44	71
+7639	PF07808	RED_N		RED-like protein N-terminal region	Fenech M	anon	Pfam-B_9780 (release 14.0)	Family	This family contains sequences that are similar to the N-terminal region of Red protein (Swiss:Q13123). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements [1]. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region [1], suggesting that these proteins are expressed in the nucleus [1]. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently [1].	20.40	20.40	20.40	21.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.67	0.70	-5.15	8	299	2009-09-10 21:25:46	2004-08-18 17:21:04	8	16	226	0	212	283	4	188.50	30	37.54	CHANGED	KKK+h.stLh+p-csc.cclspKYRDRA+ERRcGtNcDhcsssl.......ssa+AVssshtss.puu-pc+psIpESKFLGGDhEHTHLVKGLDauLLpKVRuElhsKpspE-E.......tsclststpt.h.tttp..ttcpt........p.pschpFpsplu+sI.............F+hh..hcp..............ppl.p.NEhFts.....GRMsYlh-L-sEh.-sDIPTTllRSKsDlPstctth.TlssNshlls+LuplhS.....ahRtuspspcsKKKcK	....................................................t..c.p..chsp..pYRDRA..+ERRcs.s....pDhp.p.sch.................tsh+Alt...s..h...p...h...s.....p.....s.t-.pc+.p.hIpc.SK.a..LGGDh-HTHL..VKGLDauLL..pKVR.......s....-........l.t....s.cppcc-c........................................................p.t..........................................p.pp..thtt...tp.l.............ht.....................................t.................h.................................................................................................................................................................................................................................................................................................................	0	74	115	170
+7640	PF07809	RTP801_C		RTP801 C-terminal region	Fenech M	anon	Pfam-B_5179 (release 14.0)	Family	The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene [1]. Two members of this family expressed by Drosophila melanogaster, Scylla (Swiss:Q9NHN4) and Charybde (Swiss:Q9NHN5), are designated by the GenBank as Hox targets [1].  RTP801 is thought to be involved in various cellular processes [1].  Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells [1]. Moreover, the protein product of the mouse homolog of RTP801 (dig2 (Swiss:Q9D3F7)) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment [2].	20.50	20.50	23.70	26.70	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.35	0.71	-4.43	9	137	2009-01-15 18:05:59	2004-08-19 09:24:11	6	1	74	2	82	122	0	115.20	45	52.81	CHANGED	LppAKpppLtCoclLlPscLhsplupEll+lStpEPCGlRGshl.lphEs-..pss+plAplpsDPssVsTFELhLsL+.Dpc.sWsplhsh...........Fhs.....s.uhspolpl...SssF+llKpKLYS	..............LppAK.ps..pLtCoclLlPpcLspclAp-lLRLupsEPCGLRGsllclslEpp......p.sC+cl..up.......lss.....D...P.............slVPTF..ELoLVL+.Dsp.sWsplpsh...........Fhs.......s.uhppolhL...SsuFRllKKKLYS................	0	14	19	48
+7641	PF07810	TMC		TMC domain	Fenech M	anon	Pfam-B_5063 (release 14.0)	Domain	These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 (Swiss:Q7TN63) and EVIN2 (Swiss:Q8IU68) - this region is termed the TMC domain [1].  Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis [1]. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters [2].	25.00	25.00	25.40	28.80	20.80	23.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.30	0.72	-3.64	26	598	2012-10-02 00:51:22	2004-08-19 09:39:48	8	5	96	0	316	501	1	108.80	41	14.30	CHANGED	CWEThVGQEhY+LllhDFlhollsslhs-F.R+lhschh........hhhphhuhtEFsIspNVLcLlYuQTlsWhGsaFuPLLPslsslKLhllFYlKKhoLhtsspPsp+saRAS	.......................................................CWEThVGQ.Ehh+LhlhDhlhol.hs.hLls-FhR.tlhl.chh.........sh.hph...uhsEFcIucNVLpLl....YsQshhWhGsFFuPhLPs...lssl+Lhlhh.Yl+ph..ulhpsshP..tp+sFRAS..............	0	69	95	195
+7642	PF07811	TadE		TadE-like protein	Fenech M	anon	Pfam-B_9054 (release 14.0)	Family	The members of this family are similar to a region of  the protein product of the bacterial tadE locus (Swiss:Q9S4A6). In various bacterial species, the tad locus is closely  linked to flp-like genes, which encode proteins required  for the production of pili involved in adherence to  surfaces [1]. It is thought that the tad loci encode  proteins that act to assemble or export an Flp pilus in  various bacteria [1]. All tad loci but TadA have putative transmembrane regions [1], and in fact the region in  question is this family has a high proportion of hydrophobic  amino acid residues.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.76	0.72	-4.07	180	2004	2012-10-01 21:13:59	2004-08-19 09:47:00	7	12	920	0	798	1915	145	42.30	26	24.50	CHANGED	GssslEaul.lhPlhl.hllh...uhlchuhhhhspptlppAsppu...AR	.......GssslEFul.lhPlll.hllh....ullphuhhhhs....ppslspAuppuAR...................	0	265	502	654
+7643	PF07812	TfuA		TfuA-like protein	Fenech M	anon	Pfam-B_9826 (release 14.0)	Family	This family consists of a group of sequences that are similar to a region of TfuA protein (Swiss:Q52872). This protein is involved in the production of trifolitoxin (TFX), an gene-encoded, post-translationally modified peptide antibiotic [1]. The role of TfuA in TFX synthesis is unknown, and it may be involved in other cellular processes [1].	25.00	25.00	25.30	38.70	21.70	19.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.56	0.71	-4.66	32	184	2009-01-15 18:05:59	2004-08-19 09:53:57	7	2	149	0	90	162	10	118.40	46	33.95	CHANGED	DGlFtpssuVtH+EILtAlppGltVhGuuSMGALRAAELssaGMhGlGpIachY+cGtl......tsDDEVAlhasssph..tsLo.PLVNlRtTLptAhpssllsppttppLlssAcslaascRT	......DGhFhppsuVhHKElLt.AlspGVpVhGuuSMGALRAAELcsFGMhGlGtlFctYRcGhl.............psDDEVAVsHuss-.G..a.slopsLVNlRtTLptAhtsGllsspttcpllpsA+uhaaspRT..............................	0	24	50	66
+7644	PF07813	LTXXQ		LTXXQ motif family protein	Bateman A, Fenech M	anon	Pfam-B_6101 (release 14.0)	Family	This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP (Swiss:P32158). This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH [1]. Another member of this family, Spy (Swiss:P77754) is also a periplasmic protein that may be involved in the response to stress [2]. The homology between CpxP and Spy may indicate that these two proteins are functionally related [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.52	0.72	-3.55	46	1977	2012-10-02 12:34:46	2004-08-19 10:47:52	7	6	1152	10	392	1261	72	99.30	31	59.45	CHANGED	thttthstlhppLpLT-pQcsphpsltpshcsptpsh..........ppphtshtt................stssspclt..pphhstphct....hpthtpshpphhshLosEQ+pphcplt	...................th....tpshhacsL..sL..T-pQ+....pQh+-lh....pp....tR....cphpts...............shp-.h.c.sh+chh.....................sucsFDc..sts....cs..p..h.......p....c.....ht.ppptsp.....tl.t.hhcspsphYplLTPEQ+pphstp.h...................	0	95	201	302
+7645	PF07814	WAPL		Wings apart-like protein regulation of heterochromatin	Fenech M	anon	Pfam-B_9039 (release 14.0)	Family	This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure [1]. hWAPL (Swiss:Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [2]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [2].	23.90	23.90	24.00	24.00	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.97	0.70	-5.73	13	255	2009-09-14 15:20:58	2004-08-19 10:52:24	8	8	180	0	167	258	0	313.30	27	34.01	CHANGED	spsVKshpElpEhGEppEacD-lEYlLsuLc.sssshusRCLShlsLsoKChssuFRhplRA+Gh.sp+lh+sltDspcc...........................shuLssuslhalLopDthshch..DppslclhlpLLc.............................tsspcps...t.spptls+spptlhchscphc..s.....sp+hclcslosutLAhEoh.........hShosp+sGt.FK-cLR.LGuL-+llchlt-sht.........spst..ctpss.hpplhtlp+CL+lLEssolhsspNQsallpappuhhspptsphhpphptphhph...............................hhshl+lllNLTpsssp...chuosthspp.shlsssh.phhphsshlspcssa-hplLuLulLINLsEpSppsR	.....................................................................................................................l+php-lhchGEppcapD-l-alls..sl...p..s..s....p....sh.sh.RphS.hlpLssKhh..spF+hph.......Rup.Gh.s....tplhcsltstt.pc...........................shulss.u.sl....hhlLspst....shcl........cps..s...l...clhlpLLc......................................pt.....spstc............pppphsK...h.p.pt...l.hphs.cpl.p......................sp.......ph.c.l.p.shohuhLshEsl.................hsho.ppsst.h.+pplh.hGhL-pl....lchlhp..t...................p.s....tt.ptthhtshh.hhtp.sL.pl...LE..s.....sT..h...hs.....p...NQtal...ls..h..p.p...s...hh.....t.s..h.hhpt..stt...h.ph..............................................................................................................................................................................................................................hhhhltlllNlTpss.....p.hu.sp.t.h........spt...t.hl..s.sh....hhh..p..s..t.h..s..p..p...ph......h-hhlLhLshhlNhs..s.....................................................................................................................................................................................................................................................................................................................................	0	48	80	126
+7646	PF07815	Abi_HHR		Abl-interactor HHR	Fenech M	anon	Pfam-B_9732 (release 14.0)	Family	The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact  with Abl-family tyrosine kinases [1]. More specifically,  it is termed the homeo-domain homologous region (HHR), as it  is similar to the DNA-binding region of homeo-domain  proteins [2]. Other homeo-domain proteins have been  implicated in specifying positional information during embryonic development, and in the regulation of the expression of  cell-type specific genes [2]. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved  in cytoskeletal reorganisation, but their precise role remains  unclear [1].	19.60	19.60	20.00	19.70	18.40	18.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.80	0.72	-3.87	11	332	2009-01-15 18:05:59	2004-08-20 13:21:50	9	4	91	1	135	371	0	76.80	62	17.42	CHANGED	IuQsV-lHKEKVARREIGsLTssKpssRspKIluPus.....E.hh+YpRpPIsaosLDslGHGl+.st.....sspttp.pGol	...................ISQTVDIHKEKVARREIGILTTNKN.TSRTH.KIIAPAN....hERPVRYIRKPIDYTlLDDlGH..GVKh.h..p.tt................h...................	2	27	40	81
+7647	PF07816	DUF1645		Protein of unknown function (DUF1645)	Fenech M	anon	Pfam-B_8798 (release 14.0)	Family	These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.	21.60	21.60	21.60	21.60	21.00	21.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.90	0.71	-3.84	19	218	2009-01-15 18:05:59	2004-08-20 13:23:27	6	2	22	0	123	199	0	182.70	20	62.30	CHANGED	ADELFpsGpIRPlp............Plhsh...............................................................Rut.hphtspss.t.s......hRcshRsLSP.cst.................s.stpssppsp.pussPsshs.................sosssuss...pSsSsuuS++WR.L+DLl..LhRSpS-G+cs..........u+cshhphs..st.....................p.hh.su.cspts..................tsossts+pcspt.soAH-hhYssp.R.A....tuE-h+RR....TaLP	.....................................................................................................ADElFtsGpI+Phh.......................Phht......................................................................ptt.hp.tsts.....................h+t.h.+ph....ctt........................................................tttpssttsp.psssst..s.hs............................ssssspsp.....pS.sSstu..s...++W+..lpDhh...lh.RS.pS-G+pp..................s.p.....t.....................................................t..t.t.t.......................t..tttp....huscc..h..Y..t.t..t......ttt.t++....ohhP...........................................................................................................................................	0	10	65	99
+7648	PF07817	GLE1		GLE1-like protein	Fenech M, Wood V, Finn RD	anon	Pfam-B_9182 (release 14.0)	Family	The members of this family are sequences that are similar to the human protein GLE1 (Swiss:O75458). This protein is localised at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm [1,2].	20.30	20.30	20.40	21.20	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.57	0.70	-5.45	22	279	2009-01-15 18:05:59	2004-08-20 13:27:05	8	5	230	4	208	288	4	240.30	25	41.92	CHANGED	htspIpph+pslht.lp.pcsplKchhspt+RpINsphGQlosop.ppltclhpclhph..........lstsps.s.L....uhpallshlAKtlVpQAEoE.lts+s..puAhPlAtlsh.hlhppaP-ht-hLhA+hhKKCPall....uaspuh..ssE-h+pphGa+cs.sss.hEcpssY.cRhuGhhpLaAAlsphph.tsphs.............................saulppu..W+aLARhlNh.st..........sssphsllusah-sAutphhptYupQhhKlLplltpc	................................................................................................thh.th...hp..ps.phKp.hhhphp+ths......h.l..uQl.....o....s.....s....pplpchhpc.ltph............................................t....hp...shs....pst.....................shta...hh.hhA...cthlpQs-sE..lssp......puAhPluh.lss...t.....lhp......t......h......P......c....h..t.......-llhA..+hh.+pCPahl.....shpp..s........spE..ch...........pc.hlG..........a........p....hp......s..........s...........t..hEpppsah...cRMsGhhplYAAlh.phphshsptp..............................pPaslspu..WpaLApllNh.Ph...........ssspsslLhshLcssutthhptY..tt.QhhKhl.hl...t.........................................................	0	69	110	165
+7649	PF07818	HCNGP		HCNGP-like protein	Fenech M	anon	Pfam-B_9462 (release 14.0)	Family	This family comprises sequences bearing significant  similarity to the mouse transcriptional regulator  protein HCNGP (Swiss:Q02614). This protein is localised to the nucleus and is thought to be involved in the  regulation of beta-2-microglobulin genes.	21.30	21.30	21.40	21.50	20.50	19.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.08	0.72	-3.95	22	256	2009-01-15 18:05:59	2004-08-20 13:28:23	8	6	213	0	187	254	3	94.20	34	31.46	CHANGED	IPPpPs.ucssstLppKlp+hhclKc..puhchNppltssppa+NPulhcKlhcahsID-...huTsaPt-lasPps.asp.sYh...-tLscsQ+ch..tchpp..K	...............................................lPPpPs.Gp.ss......s......p...LppKlp+.hhphKp.......pG.hchNpplppp+paRNPulhcKLlpassI.DE..............hGTsaPt-.laDPp.......s...asppuYh...-tLtcsQ+tt.hc+h-pt.p............................	0	64	102	147
+7650	PF07819	PGAP1		PGAP1-like protein	Fenech M	anon	Pfam-B_9244 (release 14.0)	Family	The sequences found in this family are similar to PGAP1 (Swiss:Q765A7). This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is  conserved in a number of lipases. PGAP1 functions as a  GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.42	0.70	-4.76	20	1253	2012-10-03 11:45:05	2004-08-20 13:29:28	8	39	770	0	638	5035	1134	153.30	17	24.56	CHANGED	clsGlPVLFIPG...NAGSa+..........QlRSlAuss..............pcs..ptsshp..............................................................hDaFolDFsE-hoAhaGpolh.-Qs-YlscAI+hILshY............tss.tsPpSVlllGHSMGGlVARshlshssahs....sslsoIlTLu.oPHstsPlshDsslhchYpplsphWpp.................tht.t.t...........LpslsllS.....lsGGhpD....hhlsu-aoslcs....hls.osuhpshoouIspVW.......hshDHhAllWCpQLhhtlu+sLhph	..................................................................................................................................................................t......................................................................................................................................................................................................................................................................................................................................................................................................h...t.......h......h.........p...t.....l...h.p.hh............................................................ts.pp....l..h...lluHSM.G.G..l..l.............u...+....t.h....l......h........h.......s.......t.t.......................p.....l.....p.....t....l...l...s.......lu..........o..P.....H.t...u....s......s......h..............................................................................................................................................................................................................................................................................................................................h................................................................................................................................................	0	197	363	534
+7651	PF07820	TraC		TraC-like protein	Fenech M	anon	Pfam-B_9690 (release 14.0)	Family	The members of this family are sequences that are similar to TraC (Swiss:Q84HT8). The gene encoding this protein is one of a group of genes found on plasmid p42a of Rhizobium etli CFN42 that are thought to be involved in the process of plasmid self-transmission. Mobilisation of plasmid p42a is of importance as it is required for transfer of plasmid p42a, which is also known as plasmid pSym as it carries most of the genes required for nodulation and nitrogen fixation by the symbiotic bacterium. The predicted protein products of p42a are similar to known transfer proteins of Agrobacterium tumefaciens plasmid pTiC58 [1].	20.80	20.80	20.90	23.30	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.90	0.72	-3.79	15	82	2009-01-15 18:05:59	2004-08-20 13:31:27	7	1	62	0	22	74	1	82.60	40	94.92	CHANGED	KKPouKIR-EIAKLQEQLKpAETREAERIGRlALKAGLGEIEI-EuELQuAFEElApRFRuGctsssG.........uuusuopssussuoGAuAGusuEA	...............Kps.tclcsEIt+Lp-pL+ph-s+pAERIGRlAlKuGLu-lEIs-sclpttFE-lAtRFRpGtttt.t.................................t...............................	0	1	8	14
+7652	PF07821	Alpha-amyl_C2		Alpha-amylase C-terminal beta-sheet domain	Fenech M	anon	Pfam-B_1278 (release 14.0)	Domain	This domain is organised as a five-stranded  anti-parallel beta-sheet [1,2]. It is the  probable result of a decay of the common-fold.	20.10	20.10	20.40	22.40	19.60	17.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.81	0.72	-4.10	33	290	2009-01-15 18:05:59	2004-08-23 10:31:22	7	8	64	15	116	300	10	61.20	48	13.67	CHANGED	pRsuIpsp.SslcIltA-uDLYsAhIDs..................KlhhKIGsc.....shhP....s...saplsssGp-YAVWEK	........pRsGIpup.Ssl+IL..tA-...uDhYlApI.Ds..................KVlsKIGs+hD.hssllP....s.......sa.p.hus.pGpDYAVWEK.............	0	30	72	97
+7653	PF07822	Toxin_13		Neurotoxin B-IV-like protein	Fenech M	anon	Pfam-B_66513 (release 14.0)	Domain	The members of this family resemble neurotoxin B-IV (Swiss:P01525), which is a crustacean-selective neurotoxin produced by the marine worm Cerebratulus lacteus. This highly cationic peptide is approximately 55 residues and is arranged to form two antiparallel helices connected by a well-defined loop in a hairpin structure. The branches of the hairpin are linked by four disulphide bonds. Three residues identified as being important for activity, namely Arg-17, -25 and -34, are found on the same face of the molecule, while another residue important for activity, Trp30, is on the opposite side. The protein's mode of action is not entirely understood, but it may act on voltage-gated sodium channels, possibly by binding to an as yet uncharacterised site on these proteins. Its site of interaction may also be less specific, for example it may interact with negatively charged membrane lipids [1].	20.90	20.90	26.70	129.30	18.10	16.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.17	0.72	-4.05	2	2	2009-01-15 18:05:59	2004-08-23 10:33:18	6	1	1	1	0	4	0	55.00	75	100.00	CHANGED	ASuTWGuuYPACENNCRKpYD.CI+CQGKWAGKRGKCAAHChlQpssCpsKCKKc	ASuTWGuuYPACENNCRKpYD.CI+CQGKWAGKRGKCAAHChlQpssCpsKCKKc	0	0	0	0
+7654	PF07823	CPDase		Cyclic phosphodiesterase-like protein	Fenech M	anon	Pfam-B_73368 (release 14.0)	Domain	Cyclic phosphodiesterase (CPDase, Swiss:O04147) is involved in the tRNA splicing pathway. This protein exhibits a bilobal arrangement of two alpha-beta modules. Two antiparallel helices are found on the outer side of each lobe and frame an antiparallel beta-sheet that is wrapped around an accessible cleft.  Moreover, the beta-strands of each lobe interact with the other lobe. The central water-filled cavity houses the enzyme's active site [1].	20.40	20.40	21.00	20.40	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.50	0.71	-4.82	15	138	2012-10-03 21:31:48	2004-08-23 10:36:00	6	4	118	6	92	200	152	191.60	23	91.61	CHANGED	M.......................hu..........lWhhPst..s.h.phppLl.puLpslFs......sp..........PsFEPHlTlsuslslc......sps-lpclLpu.ussulcul..t..................hlplssVssGcpYFc+lalplptsstLhulAplh+phFs...st.t................................................t.spaspptatPHlSLlYuDlp.h-p..sphptltpclccsh...............................suhuWs...hspltLVpC-Gs...Vc-WpllushsL	......................................................................hulWhhPst..shh.....pplptlh..tslpshas.....s.................PhFpPHlTlsu..s.lphp.......pts..ss..p..ph..Lpu..sssu.hpsh............................hlphsslss...u.c.p.a..a..pplalt.lp.s..t.lh...shsphh+phh................................................................tthspptahPHlSLl.Yu..Dl...cp....t.htth..tp.p..lpst......................................t.hsap....sphtlh...s...ps......lppWphltth.h...............................................................................	0	35	63	83
+7655	PF07824	Chaperone_III		Type III secretion chaperone domain	Fenech M	anon	Pfam-B_32938 (release 14.0)	Domain	Type III secretion chaperones are involved in delivering virulence effector proteins from  bacterial pathogens directly into eukaryotic cells. The chaperones may prevent aggregation and degradation of their substrates, may target the effector to the  secretion apparatus, and may ensure a secretion-component unfolded confirmation of their specific substrate. One member of this family, SigE (Swiss:O30917) forms  homodimers in crystal. The monomers have a novel fold  with an alpha-beta(3)-alpha-beta(2)-alpha topology [1].	25.00	25.00	25.40	38.40	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.45	0.71	-4.16	4	132	2012-10-01 22:01:34	2004-08-23 10:39:55	7	2	125	2	3	37	0	106.40	88	98.71	CHANGED	csll.pLYcALGL-.hshD-PAllIDDDlpIYFsEut-uLEMsCPhhsLP-slppLQphLpLNYASsVsLAsDA-sosLlALhRLPtpSstEEhhsGhphaIopV+pL+pchA	.......ESLLNRLYDALGLD.APEDEPLLIIDDGIQVYFNESDHTLEMCCPFMPLPDDILTLQHFLRLNYTSAVTI....GA...DADNTALVALYRLPQTSTEEEALTGFELFISNVKQLKEHYA..................	0	0	1	2
+7656	PF07825	Exc		Excisionase-like protein	Fenech M	anon	Pfam-B_46296 (release 14.0)	Domain	The phage-encoded excisionase protein (Xis, Swiss:P03699) is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual 'winged'-helix structure in which two alpha helices are packed against two extended strands.  Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue 'wing'.  During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of Xis is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DNA [1].	21.40	21.40	21.40	21.60	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.62	0.72	-4.21	2	289	2012-10-04 14:01:12	2004-08-23 10:57:07	6	2	219	9	20	95	3	71.50	39	84.80	CHANGED	hhlTLpEWstcp.RpP.S.pTlRRWsREshIhPsPVKcGRpYhhctsAshh-.p.....PVsusLlpRItsu+hutp	.......hl..lTLpEW.ss..ccF.u.t.P..o.sTLpKYu+tGhIhP.P.KlGRcWhlDcpAhFV.G...s.s.......................................................pssh.........................	0	2	10	13
+7657	PF07826	IMP_cyclohyd		IMP cyclohydrolase-like protein	Fenech M	anon	Pfam-B_50235 (release 14.0)	Domain	This enzyme (Swiss:O27099) is may catalyse the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily.  A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family [1].	25.00	25.00	27.50	37.40	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.33	0.71	-4.97	6	187	2009-01-15 18:05:59	2004-08-23 11:01:02	6	2	187	13	63	183	27	212.30	40	92.54	CHANGED	MYlGRFLllG+sppG.shssYRVSSRSFPNRpshphs-ssssllPcDspE..hhcNPYIoYNClRlVs-ssVVoNGSHTDsIA-KlchGhs.RDALs.uLhsMDYEKD-YN.TPRIAullst-c.ualGhVss-cl..........hh+hsElcsGcuahLosYpt...ststhhshcucos.....E-sschsh...phtsFEHsVsuAsshhcs.........-GaclA.spsh	......................YPGRGIllG+o.t-G.pslsAYaI.......MGRS....sSRN.R.l..h.l..c-.......s..p...s.h.s..p..sh..Dsuc..lpDss.LIIYsPVRll.......G....s..psIVTNGDQTDTIhE....GhstptoFppuLpoR-aEPDuPNaTPRISGll...........c....h-s......s.h...hSIl.Ks.ssss.t..............s.RhtatapsshsGEGaaIpTYpp......Dus.PL....PSF-GEPt.h.......s-hsphs.....ps..Ls.-N+VSLh.s+hIDh.........tth.......thst......................................	0	22	44	57
+7658	PF07827	KNTase_C		KNTase C-terminal domain	Fenech M	anon	Pfam-B_29524 (release 14.0)	Domain	Kanamycin nucleotidyltransferase (KNTase) is involved  in conferring resistance to aminoglycoside antibiotics  and catalyses the transfer of a nucleoside monophosphate  group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains.  The C-terminal domain contains five alpha helices, four of which are organised into an up-and-down alpha helical  bundle. Residues found in this domain may contribute to this enzyme's active site [1].	26.40	26.40	26.50	27.00	22.90	26.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.80	0.71	-4.44	2	78	2012-10-01 22:14:54	2004-08-23 11:06:00	6	2	70	2	9	39	0	137.40	69	57.06	CHANGED	DstGahp+lh.sAcSsptpsF+pAIptllVtEhaEYsGKhRNlphpGPoTaLPSLslphAhhGAMLIGLHpphhaoTuA.VLsEAlK.schPpGaDHlsphsMSGpLupstKllpuhEsFWpGl.tWstcHsYllc.SKRIPF	................DSGGYLEKVYQTAKSVEAQTFHDAICALIVEELFEYAGKWRNIRVQGPTTFLP.SLTVQVAMAGAMLIGLHHRICYTTSASVLTEAVKQSDLPSGYD.HLCQFVMSGQLSDSEKLLESLENFWNGIQEWTERHGYIVDVSKRIPF..........	0	3	7	8
+7659	PF07828	PA-IL		PA-IL-like protein	Fenech M	anon	Pfam-B_99281 (release 14.0)	Family	The members of this family are similar to the galactophilic  lectin-1 expressed by P. aeruginosa ((PA-IL, Swiss:Q05097).  Lectins recognising specific carbohydrates found on the  surface of host cells are known to be involved in the  initiation of infections by this organism. The protein is thought to be organised into an extensive network of beta-sheets, as is the case with many other lectins [1].	20.80	20.80	21.60	46.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.63	0.71	-4.32	2	27	2012-10-03 19:46:52	2004-08-23 11:09:01	7	2	21	15	9	19	1	113.30	56	91.42	CHANGED	sWpGpV.ANsEsGpsTulIhp.GDsIolVAtGWspYG.sph.hstsDt.hPsp...spsu.husLVhKIuNpthh.sNssLa+hVs...VpGtlhLlaNDVPGTaGsNSGpFpVplhh-pp	.sWpGpV.ANsEsGQsTulIhpsGDVIoIVAuGWspYG..sppahstsptchP.....cphhhspsshssuLlhKIGNpuhh.sNsGLa+hVs...VpGtloLlaND..VPGoYGNNSGuFSVNlth-pp....	0	1	2	7
+7660	PF07829	Toxin_14		Alpha-A conotoxin PIVA-like protein	Fenech M	anon	Pfam-B_46690 (release 14.0)	Domain	Alpha-A conotoxin PIVA (Swiss:P55963) is the major paralytic  toxin found in the venom produced by the piscivorous snail  Conus purpurascens. This peptide acts by blocking the  acetylcholine binding site of the nicotinic acetylcholine receptor at the neuromuscular junction [1]. The overall shape of the peptide is described as an "iron" with a highly charged  hydrophilic loop of 15S-19R forming the "handle" domain that  is exposed to the exterior of the protein. The stability of  the conotoxin is primarily governed by three disulphide bonds. A triangular structural motif formed by residues 19R, 12H and  6Y is thought to constitute a "binding core" that is important in binding to the acetylcholine receptor [2].	25.00	25.00	30.70	57.60	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.29	0.72	-4.21	2	4	2009-01-15 18:05:59	2004-08-23 11:14:11	6	1	2	2	0	6	0	25.50	81	66.67	CHANGED	GCCGpYPNAACHPCuCp.sRPsYCsp	GCCGsYPNAACHPCuCK.sRPsYCsp	0	0	0	0
+7661	PF07830	PP2C_C		Protein serine/threonine phosphatase 2C, C-terminal domain	Fenech M	anon	Pfam-B_5253 (release 14.0)	Domain	Protein phosphatase 2C (PP2C) is involved in regulating  cellular responses to stress in various eukaryotes. It  consists of two domains: an N-terminal catalytic domain  and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices,  one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not  seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain [1].	22.70	22.70	22.80	23.90	20.80	22.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.72	0.72	-3.87	15	272	2009-01-15 18:05:59	2004-08-23 11:23:01	8	3	85	8	121	231	0	75.90	49	20.16	CHANGED	SllLlCFPGAP+VSEEAl++EtcL-chLEs+VEEllcc.sucpphPDLhpVh+sLuuEs.IPsLPPGGGLsSK+slIpsVYp+	.....................SllLlCFPsAPKVStEAV++EsELDKhLEsRVc.El....hpc...tttcshP...DL..spVh+h.Lu..uEs.....IPsLPPGGGLsu.....K..+.slIEtsYpc............	0	26	37	69
+7662	PF07831	PYNP_C		Pyrimidine nucleoside phosphorylase C-terminal domain	Fenech M	anon	Pfam-B_1661 (release 14.0)	Domain	This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases [1,2]. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP, Swiss:P77826) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP, Swiss:P07650) [1]. The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer [1].	20.50	20.50	20.50	21.40	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.21	0.72	-4.52	54	2815	2012-10-02 20:27:15	2004-08-23 11:28:27	8	10	2677	20	573	1892	417	73.80	36	16.87	CHANGED	alsplsspplGhsuhtLGAGRtpppD.IDhusGlhlp+KlG-pVcpG-slhslauscct.hcpshstlppshtIu	.......................................hloplsupslGhAuhtLGAGRtptpD.sIDhuVGlhhpt+lGDpVc..pG.c.sLssl.ausccs....hp.pshptlppulpl...................	0	197	372	477
+7663	PF07832	Bse634I		Cfr10I/Bse634I restriction endonuclease	Fenech M	anon	Pfam-B_46671 (release 14.0)	Domain	Cfr10I (Swiss:P56200) and Bse634I (Swiss:Q8RT53) are two Type II restriction endonucleases. They exhibit a conserved  tetrameric architecture that is of functional importance, wherein two dimers are arranged 'back-to-back' with their  putative DNA-binding clefts facing opposite directions.  These clefts are formed between two monomers that interact, mainly via hydrophobic interactions supported by a few hydrogen bonds, to form a U-shaped dimer. Each monomer is folded to form a compact alpha-beta structure, whose core is made up of a five-stranded mixed beta-sheet.The monomer may be split into  separate N-terminal and C-terminal subdomains at a hinge located in helix alpha3 [1].	20.70	20.70	22.80	21.60	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.54	0.70	-5.28	4	13	2012-10-11 20:44:44	2004-08-23 11:38:48	6	2	11	37	2	16	0	267.20	23	86.22	CHANGED	hssIpthsEs..GKhplN.+..assluphl-Ntlsps.phpc.LDthRs.ssctActtG...ppsusuuhspssGsW.ElMlu.......ph.chhLp.s.pp.l...VlpMPNsp..........SFDahslacsEhpEhI.phcupL..pKssltL.TSsPDlulI......E-.Ks..c-hhpp.Ist.T+ss.sh..sLYpphps+sphcclpuululKTShRPDRRhQ.laEuslhKuL.salphphW........KYahssop.lusADssuhpT...sAsHulsps+Shsp+AVD-lahhsohtDlsphlsphlpc	............................................th..hp.t....sh.p.h...hs.t.ph.c....hpshhtt.scttt...th.ssuAhsNssGsW.Ehhhu.........ltshphhhp..ssp..p...l...llphPN.p..........oaDhhpLacsphpptlpsL....cppL.......ptsplpLhoSsPDllIl........pthps..pshhh....psIsphocs.shsh.....slYpphps+sch.cslhuhlulKTShRPDRRhQ.laEusllKuL..salppptW.................hKYYutuop.lusADspuhpT...sAsHolspspshPp+AVDclaphsohtDlsphlpphl..............	1	1	1	1
+7664	PF07833	Cu_amine_oxidN1		Copper amine oxidase N-terminal domain	Fenech M	anon	Pfam-B_46519 (release 14.0)	Domain	Copper amine oxidases catalyse the oxidative deamination  of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These  enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in  some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other [1,2].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.42	0.72	-3.65	134	2772	2009-09-11 19:31:59	2004-08-23 13:46:59	6	269	442	32	1082	2618	19	86.20	21	23.12	CHANGED	tssRshVPlRhlu..-uL..G..s...pVpW.sspspslsl..pp......sspp.....lplp.l................G.....sptshl........N.......G.......pphthc..sss.h....lt...t....uR..ThVPlRaluEshG.hp...........VpW.-sp.....spslhl	...........................................................................................hhlPhc.h.........p.t.h.....s....h.......pl.ta....ptt...t...p.t....hhh...p.............................sst.t..........lp..hp.h.....................................................................s.......s.p.phh.l............................N..............G............p..p..h..phs......ssshl..........hs......uc..shVPl+.hl.u-.shG...hp...........lpa.stt...........................................................................................................................	0	649	941	984
+7665	PF07834	RanGAP1_C		RanGAP1 C-terminal domain	Fenech M	anon	Pfam-B_23411 (release 14.0)	Domain	Ran-GTPase activating protein 1 (RanGAP1, Swiss:P46061) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localisation at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1, Swiss:Q93068). This domain is composed almost entirely of helical substructures that are organised into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation [1].	25.00	25.00	27.10	26.40	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.89	0.71	-4.85	3	102	2009-01-15 18:05:59	2004-08-25 09:31:02	6	11	54	14	43	98	0	173.50	54	32.44	CHANGED	GsDuEssu+stpcPsluEsAPs.sPPhPuDlSTFLuFPSPEKLlRLGPKRSsLIAQQVDVoDsEKVVpAFLKVSSVYKDEuEVKtAVpETlDALM+KAFsNSuF.QSNoFITSLLVpMGLLKSED.KVKsIusLsGPLLTLNHMVQQ-YFPKuLAulLLAFVSKPNuVLESCuSARHoLLpTLaK	...........................tcstssppch.csss.uEss.Ps....hss...ss.PsDlSTFLuFPSPEKLLRL.GPK.sSh.L......I......sQQT..D.T.....SD..s.EK.......V....Vs........AFL........KVS...SVa..+.............D.-..u..s..V....+..oAVt-ulDALMKKAFSouoF..NSssFl..T.pLLlHMGLLKSED...Kl.K.A.I.s.sLaGPLM.sLNHh..VQQDYFPKuLAPlLlAFlTKPN....tALEoCSh.ARHsLLQTLap...................	0	10	13	26
+7666	PF07835	COX4_pro_2		Bacterial aa3 type cytochrome c oxidase subunit IV	Fenech M	anon	Pfam-B_86185 (release 14.0)	Domain	Bacterial cytochrome c oxidase is found bound to the  to the cell membrane, where it is involved in the  generation of the transmembrane proton electrochemical gradient. It is composed of four subunits. Subunit IV consists of one transmembrane helix that does not interact  directly with the other subunits, but maintains its position by indirect contacts via phospholipid molecules found in the structure. The function of subunit IV is as yet unknown [1].	20.30	20.30	20.40	20.60	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-7.95	0.72	-3.98	36	225	2009-01-15 18:05:59	2004-08-25 15:22:17	7	1	213	5	76	177	38	44.90	37	68.34	CHANGED	Hcc........utMDhstpE+TacuFl+hsphuslsllsl...LlhhAlhhs	..................Hpp......huusMDYspHE+TYsGFlthsKauolsllsl...llhMAhhhh.........	1	16	40	56
+7667	PF07836	DmpG_comm		DmpG-like communication domain	Fenech M	anon	Pfam-B_1675 (release 14.0)	Domain	This domain is found towards the C-terminal region  of various aldolase enzymes. It consists of five  alpha-helices, four of which form an antiparallel helical bundle that plugs the C-terminus of the N-terminal TIM barrel domain [1]. The communication domain is thought to play an important role in the  heterodimerisation of the enzyme [1].	21.00	21.00	21.10	24.10	19.50	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.97	0.72	-4.57	37	789	2009-01-15 18:05:59	2004-08-25 15:24:35	6	8	628	4	196	566	103	65.60	60	19.32	CHANGED	pssplDRpoLslGYAGVYSSFLhHAcRAAp+aGVDsR-ILlELGRR+hVGGQEDhIlDlAh-Lupp	............PlRVDR-oLsLGYAGVYSSFL+HsEpAAt+Y.GlsAhDILVELG+R+hVGGQEDMIlDlAL-Ltp.t..................	0	45	122	167
+7668	PF07837	FTCD_N		Formiminotransferase domain, N-terminal subdomain	Fenech M	anon	Pfam-B_4434 (release 14.0)	Domain	The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This,  in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a  short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to  form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [1].	19.20	19.20	19.80	23.20	18.10	16.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.86	0.71	-4.76	37	493	2009-01-15 18:05:59	2004-08-25 15:26:05	7	7	380	6	191	419	213	172.50	42	49.65	CHANGED	KlVECVPNFSEGRcp-hl-tIhsshp.shpGVpLLDhssDssHNRoVlThVG-P...........-slhcAshpus+hAs-LIDhppHcGp.HPRhGAsDVlPFlPlpssTMEEClplA+plGccluccLtlPVYLYpcuAspPcRcsLssIR+G..paEuht-Kl.KpscW...........cPDaGPsphp...PouGsTslGAR.	.......................pllEClPNFSEGR..spphI-...tIsps.....h......+......s.....h.....s.........G....V..pLL.DhssDtsaNRoVhT.l.V.Gc.P.......................cs.l..t-AshphschAschI....Dhsp.HpG.p........HPRhGAsDVlPFlPl.p..s.s..T..........h-EClplA+.p.....l.ucclu.c.c...l.s.lPVaLYEpuA..s.p.PcRcsLsslR+G..paEuh.tE..K..l....p.ps...c.W...................tP.Da..Gs.t...php...PosGsTslGAR.........................................	0	81	121	155
+7670	PF07839	CaM_binding		Plant calmodulin-binding domain	Fenech M	anon	Pfam-B_9279 (release 14.0)	Domain	The sequences featured in this family are found repeated  in a number of plant calmodulin-binding proteins (such as Swiss:Q8W235, Swiss:Q84ZT8 and Swiss:Q8H6X1), and are  thought to constitute the calmodulin-binding domains [1,2]. Binding of the proteins to calmodulin depends on the presence of calcium ions [1,2]. These proteins are thought to be  involved in various processes, such as plant defence responses [1] and stolonisation or tuberization [2].	21.00	21.00	22.40	21.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.55	0.71	-3.87	19	140	2009-01-15 18:05:59	2004-08-25 15:30:43	6	6	22	0	90	126	0	105.70	30	21.15	CHANGED	pppptp.ppsphhcspspppps+phpph+csll.hp+hs....pshccsh+hsshtsphls.ps-.s-sE+V.sLRH.Qcsp-..+Kcu-chMlDaAlccslSKLsssRKpKVchLVpAFETVls	....................................................................................h................t.tt.p...t....pp..hp...hcthh....tp......pt.cphtphp....t.....ph..hs.psp.....csEcV..LRH.Qpsp-..+Kpuc.hhhspslccssoKLs..sRK.pKVchLVtAFETVls...	0	12	52	72
+7671	PF07840	FadR_C		FadR C-terminal domain	Fenech M	anon	Pfam-B_11411 (release 14.0)	Family	This family contains sequences that are similar to the fatty acid metabolism regulator protein (FadR, Swiss:P09371). This functions as a dimer, with each monomer being composed of an N-terminal DNA-binding domain and a regulatory C-terminal domain. A linker comprising two short alpha helices joins the two domains. In the C-terminal domain, an antiparallel array of six alpha helices forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain. This structure was found to be similar to that of the C-terminal domain of the Tet repressor. Long-chain acyl-CoA thioesters interact directly and reversibly with the C-terminal domain, and this interaction affects the structure and therefore the DNA binding properties of the N-terminal domain [1].	23.00	23.00	23.20	23.30	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.88	0.71	-4.62	29	828	2012-10-01 22:11:53	2004-08-25 15:31:18	7	3	818	8	104	339	14	167.80	62	68.98	CHANGED	NNFWETSGLNILETLs+L.DtsthPpLl-sLLSARTNlSsIalRtAl+tNP-cs..............................hElLsphcpl--s..............AcAaspaDYpLa+pLAFsSGNPlYsLILNGhKGLYoRVGpaYFusscuRpLAhsFYcpLhplscpppa-plhthlRpYGhpSGtIWpph+ssl..Ppshs	...................................................NNFWETSGLNILETLARL.D.HESVPQLIDNLLSVRTNISo....I.FI.R.TA.hRpHP...-K.A...................................................................pEVLAsA..pE....V....sD+........................................A-AFA-LDYsIFRGLAFASGN.PIYGLILNGh..K.G.LYT.RIG.RaYFuN.PEARpLALsF....Y++LuuLCppG.s+DQVhEsVR+YG+-SG-IWH+MQcsLPuDL.A..........................................................	0	15	38	73
+7672	PF07841	DM4_12		DM4/DM12 family	Fenech M	anon	Pfam-B_5243 (release 14.0)	Family	This family contains sequences derived from hypothetical proteins expressed by two insect species, D. melanogaster and A. gambiae. The region in question is approximately 115 amino acid residues long and contains four highly- conserved cysteine residues.	21.70	21.70	21.80	21.90	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-10.08	0.72	-3.65	45	504	2009-01-15 18:05:59	2004-08-25 15:54:11	8	5	28	0	367	546	0	82.60	26	33.78	CHANGED	RpplYchlEphl.sphGh...sG..+sClLRsICEsuph.h...ctsGllu-ll+llFoPspscst.........pYhpActhGptt...s-Cppha..t.pC	..........................Rh.lYphlEphh.p...p.h..Gh.......sG+sClLRsICEs.u.phsh..........pp........pu.l.....l.u-.......ll..+llhosspsp.t................................tpYhpApphGptt..............tsCtphat.pC......................................................	0	91	117	287
+7673	PF07842	GCFC		GC-rich sequence DNA-binding factor-like protein	Fenech M, Mistry J, Wood V	anon	Pfam-B_9357 (release 14.0) & Pfam-B_9894 (release 19.0)	Family	Sequences found in this family are similar to a region of a human GC-rich sequence DNA-binding factor homolog (Swiss:Q9Y5B6). This is thought to be a protein involved in transcriptional regulation due to partial homologies  to a transcription repressor and histone-interacting protein  [1]. This family also contains tuftelin interacting protein 11 which has been identified as both a nuclear and cytoplasmic protein, and has been implicated in the secretory pathway.  Sip1, a septin interacting protein [2] is also a member of this family.	20.20	20.20	20.60	20.60	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.90	0.70	-5.04	36	631	2009-01-15 18:05:59	2004-08-25 15:56:45	7	15	282	0	392	539	6	222.60	22	31.13	CHANGED	LppltptFcphppca.pcYc...phtLuplAsuhltPLl+pthhsWsPLcsss...hlt.htph+.lL................................t..ssYcshlWpshlsthp.sshspWpst.sssshlsllptW.slLP.hhhpsll-plllP+Lp..ptVpp.WcPhocsh.....sh.p....sWlaPWLPhLs.p+hcs....................lhssI+pKlppsLpsWp.p.tush.hLp.W.pclass...........tpasshlhppllP+LtttLp...ph.lsP.pp..Qs..lchhptlhpWpsllssphhspL..l.ppFFsc...WhpsL	.................................................................................................................................................................pthhphFpphpppa.ppYp...ph.lu.hhst.hltPll+.plh....s.Ws.P...........L...............ppss.....................................................................psa.c.ph..hW..hhh.hh...t.t.....t.php.c.....ps..............ss..h...plls....................................s.ll-.p........lllP+Lp..thlcp..Wc............Pho.ss...............sh.p...........hlhshh..sh.h..t.....t.p.hcs....................lhpslht+h.ppsl........p.p.......................................slahs............................a.t....h..h.p.phhsthth.hhp...........tp.....ps.......h.chht.lhtW...p..shls...ph.............hhtl..h.t.phhs+...a......................................................................	2	116	174	305
+7674	PF07843	DUF1634		Protein of unknown function (DUF1634)	Fenech M	anon	Pfam-B_9594 (release 14.0)	Family	This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many  hydrophobic residues.	21.00	21.00	21.10	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.20	0.72	-4.40	45	351	2009-01-15 18:05:59	2004-08-25 16:01:49	6	4	335	0	99	238	4	98.50	34	79.49	CHANGED	IutlLRhGVlluusllhlGhllhhlpssu...............h...ts..hs.stlhpuhhthcuhslI..hhGLhlLIhTPlhRVllulhsFhpE+DhlYssIoh.....lVLhhLhhul...hl	..............................................................IuplL+hGVhluuhlIhhGllhhhlpsts...................t...ht..tlh.puhht......hpshsll..hhGlhlLIlTPVLRVslulhsF.hpE+DhhYVh.ITslVLhIlhhuhl...........	0	39	67	87
+7676	PF07845	DUF1636		Protein of unknown function (DUF1636)	Fenech M	anon	Pfam-B_9608 (release 14.0)	Family	The sequences featured in this family are derived from a number of hypothetical prokaryotic proteins. The region in question is approximately 130 amino acids long.	28.10	28.10	28.10	28.50	28.00	27.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.56	0.71	-3.85	52	189	2009-01-15 18:05:59	2004-08-25 16:05:15	6	1	150	0	66	191	92	110.70	33	83.77	CHANGED	lhVCsoC+tt.......tss.psGttLhstLpst..t.s..tt...lplpsVpCLsuCs+..uCsVAlp.uss+hoYlaGcl....sst...sssssllshAthYtsoscGhlPa+cRPptl+cphlARIPP	........................lhVCsoC+ts..........tss.ps...GttLhstLpst..........s......ts...lplcsVpCLuuCs+..sColAlp.usu+hoYlaGcl....ss......ssupsllshAphYtsos-GhlPapcRPpsl+cthlARlPP...............	0	12	42	48
+7677	PF07846	Metallothio_Cad	Metallothio_7;	Metallothionein family	Fenech M	anon	Pfam-B_9622 (release 14.0)	Family	The sequences making up Metallothio_Cad are found repeated in metallothionein proteins expressed by several different Tetrahymena species. Metallothioneins are low molecular mass, cysteine-rich metal-binding proteins that are thought to be involved in the regulation of levels of trace metals, and detoxification of these metals when present in excess [1]. Some of the metallothioneins found in this family (for example, Swiss:Q8T6B3) are known to be induced by cadmium and are thought to be involved in the cellular sequestration of toxic metal ions. The high proportion of cysteine residues allows the metal ions to be bound by the formation of clusters of metal-thiolate complexes [1]. Tetrahymena spp. metallothioneins differ from other eukaryotic metallothioneins mainly in the length of their sequences and in the cysteine-containing motifs they exhibit.	19.50	19.50	24.70	23.70	16.80	15.80	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.37	0.72	-4.02	4	42	2012-10-04 14:35:37	2004-08-25 16:06:25	6	4	9	0	0	48	0	20.80	83	35.79	CHANGED	CCCGsNAKPCCTDPNSGCCCV	CCCG-pAKsCCTDPNSGCCCs.	0	0	0	0
+7678	PF07847	DUF1637		Protein of unknown function (DUF1637)	Fenech M	anon	Pfam-B_6051 (release 14.0)	Family	This family contains many eukaryotic hypothetical proteins. The region featured in this family is approximately 120 residues long. According to InterPro annotation, some members of this family may belong to the cupin superfamily.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.52	0.71	-4.95	32	328	2012-10-10 13:59:34	2004-08-25 16:08:44	7	5	139	0	188	457	26	187.40	32	75.01	CHANGED	llcplpspDlslpsphth......................................stp...hssloYhcl.aEs-.sFShulFhLssuusIPLHDHPGMsVhpKlLaGpl+lcSaDhlc........s.ssstt.p............s+hAplh.sssp....hosssssslL...hPpp.........sNlHphsAls...PsAhLDlLuPPYs...sstG.RcCsYYcthshss...........t........................................hsaLpEh...s.Pcsah.hts..Y.GP.pl	...................................................................hsphpstDltlt.t....................................................t..sslsYhc..l..a..Es..c....sFS...hu.....lF.h.L.P.s..uu.sIPLHsHPuMsV......hoKlLa.Gsl+lcSYDhlc................s...s........tt......................................................h+hAplh.h-s..........housss.sslL...hPpp...............GNlHphsAls......ssAhLDlL.......uP..PYs...........t...tG....RcCsYYc.h..sp..........................................................t.shL.ch.....Ppshh.htt..Y.GP.................................................................................................	0	43	102	152
+7679	PF07848	PaaX		PaaX-like protein	Fenech M	anon	Pfam-B_9563 (release 14.0)	Family	This family contains proteins that are similar to the product  of the paaX gene of Escherichia coli (Swiss:P76086). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid [1].  In fact, some members of this family are annotated by InterPro as  containing a winged helix DNA-binding domain (Interpro:IPR009058).	22.70	22.70	22.70	22.80	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.04	0.72	-3.98	13	652	2012-10-04 14:01:12	2004-08-25 16:08:49	7	2	571	5	164	630	53	68.10	38	23.66	CHANGED	pApSlIlTLaGDhlts+GGslhlusLIpLhtshGlsEpslRsAloRhsppGhLssp+sGp.puhYpLS-+u	.................................upSLIholaGD..lt.t.+.G....u.p..lhluuLlt.Ll.p.s.h...G..hsEphVRoALhRLs+cGhL....ss.s...+hG..R.puhYpLo-p................	0	45	102	139
+7680	PF07849	DUF1641		Protein of unknown function (DUF1641)	Fenech M	anon	Pfam-B_9217 (release 14.0)	Family	Archaeal and bacterial hypothetical proteins are found in this family, with the region in question  being approximately 40 residues long.	20.30	20.30	20.40	20.70	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.29	0.72	-7.74	0.72	-4.34	60	843	2009-01-15 18:05:59	2004-08-25 16:10:27	6	1	521	0	181	438	10	40.50	33	23.65	CHANGED	shpshcssp......lulhsLl+tL+DPDlp+uLGhhlshLKslG+s	..................s..pphpsscc.....sulhuLl+.s.LKDPDhpRulsahlshLKuhup.........	0	52	107	147
+7681	PF07850	Renin_r		Renin receptor-like protein	Fenech M	anon	Pfam-B_9266 (release 14.0)	Family	The sequences featured in this family are similar to a region of the human renin receptor (Swiss:Q8NG15) that bears a putative transmembrane spanning segment [1].  The renin receptor is involved in intracellular signal  transduction by the activation of the ERK1/ERK2 pathway,  and it also serves to increase the efficiency of angiotensinogen  cleavage by receptor-bound renin, therefore facilitating  angiotensin II generation and action on a cell surface [1].	21.30	21.30	21.70	21.60	21.20	19.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.25	0.72	-3.65	8	137	2009-01-15 18:05:59	2004-08-25 16:10:47	9	4	93	4	83	131	0	95.90	43	27.64	CHANGED	shYGGsAVVEllT..scoh-ssLsRcsRsIlpocs..............hpssssPYNLAYpYsh-YuVIFNIlLWlhlsLuLAVIsISYslWsMDPGhDSIIYRMTsQ+I+hD	......................................................................t.hYsusslVphls....csh-ss.hhRpsRs..llp..scp...................................psss..sPYNLA.hp..Ysh-.Y...sVl..FNIlLWhMlsLuLullslsYslh.N.MDPGhDSIIYRMTsp+l+hD........	0	27	34	59
+7682	PF07851	TMPIT		TMPIT-like protein	Fenech M	anon	Pfam-B_9674 (release 14.0)	Family	A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.	22.90	22.90	25.40	23.50	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.09	0.70	-5.36	14	274	2009-01-15 18:05:59	2004-08-25 16:11:51	8	8	130	0	167	257	5	265.40	39	89.51	CHANGED	cshpEWp-Lpc-appLp-TH+hYppKLE-lspLQppCossIs+Q+++L+plppsL+phpts.......lss..E-hctlpclcppl+cRpstha-ME..uaLPcK.NGlYLsLlLG.sVNVoLLs+psKFtYKDEYEKFKLhlTlIhllhuhhCpalhsY.......RshDtlFsFLLVWYYCTLTIRESILhsNGSRIKGWWlhHHYlSThhuGVhLTW.....PpG.haQhFRsQFl.FshY.ShVQaLQahYQuGCLYRL+ALGERHpMDlTlE....GFpSWMWRGLoFLLPFLFhGahaQhYNuhTLFphuppspsp.EWQVhhhuhhFLlLFlGNhhTTLtVVhpKhppp...p	............................................................................tlpptt.p..ah.phpphtthpp.psttlpppph....p....h.pplt.slp..pht.................t.phhpplptp...hpctpshhh......-h-......shL.Pp+.sGh.aLplhLG..sVNVphhppps+htaK-................EYEpFKhhhsllhllhshhhhhlhph......................phhsthaphhLlaaYsTLslREsILhsNGS+I+uWWl.HHYlSshhusVhLTW.....P.s.s.ha.........QhFpppF...L......tauhhQ..uhVQhLQ.hYQpGpLYphhALGc.tpphDlo...p....G.pu.hhhtt.....Lh.hLhPh.LFhhph.aQhY....suht.Lh...........ph......u..............sp...pW.............Q.......V.h...huhhh...llhhhGNhhsTl.slhtKhp.p....t.......................................................	0	49	72	121
+7683	PF07852	DUF1642		Protein of unknown function (DUF1642)	Fenech M	anon	Pfam-B_9838 (release 14.0)	Family	The sequences making up this family are derived from various hypothetical phage and prophage proteins. The region in question is approximately 140 amino acids long.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.16	0.71	-3.83	54	426	2009-01-15 18:05:59	2004-08-25 16:12:14	6	4	292	0	26	304	0	123.50	24	69.65	CHANGED	pthshVP...phVA-aIEppK..tt.........hpshphh.h.tp.........................................chhpW...........ss.chhhpAals..G............YpVEK......EpLYhVcl.ps.....................h.hhppth..t...................hphTcpEI.cp.s..chtWtat......lcVc	...................................................................thshVP...phVA-Wl-ps+........pp.................phh.t.....h.pp.............sp.....................ch.pW.............h...hppshch.....hs.pAals..G...............YEVEK......Eph.YhVcl.t.t........................hh.h.tpph.......................hphTcpEl.cp.s..ph.W.at......h.l..................................................	0	9	16	20
+7684	PF07853	DUF1648		Protein of unknown function (DUF1648)	Fenech M	anon	Pfam-B_9801 (release 14.0)	Family	Members of this family are hypothetical proteins  expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane  proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	28.70	28.70	28.70	28.70	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.32	0.72	-4.45	86	1279	2009-01-15 18:05:59	2004-08-25 16:13:32	6	12	929	0	232	913	44	52.80	25	26.36	CHANGED	hllhlhshlhsh..hhaspLPcplssHashsGpsDsassKh.hshhhhPl.......lhlh	......................hlhlhhhhhsl....hhY...s....p.LPsp..lPhHash.sGp.sDsassKh..hslh.hhPh..hhh.h.....................	0	95	171	201
+7685	PF07854	DUF1646		Protein of unknown function (DUF1646)	Fenech M	anon	Pfam-B_9337 (release 14.0)	Family	Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei (Swiss:Q8PXG5, Swiss:Q8PXG7 and Swiss:Q8PXG8).	20.30	20.30	20.40	20.30	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.00	0.70	-5.32	6	83	2012-10-02 15:12:49	2004-08-25 16:13:47	7	2	52	0	45	108	23	323.20	43	93.85	CHANGED	lAuLlVILlLlLlLPFhl+hlEcNLEhFhhsM...GlAushlSGl.........aSh-LlhcAFcsPLtlhp..lh.IPlGIsQsVLlsGLlFaha+c+lhphltpsh-+lul+VFuFllIslLGLhSSlISAIlAulILsEllshhPLsRKsKlchsVIAsFuIGhGAALTPlGEPLSTIAlSKL.....NtcFhYLhclLGhYIIPulhshGlhusahlp+hsh+p.hlEh..V-YsEsl+-......VllRAhKVFVFIhALpLLGpGFKPlIhhYlsclsSclLYWlNhlSAllDNATLAAAEIuPphTpEQIRuhLMGLLISGGMLIPGNIPNIluAG+L+Is.pEWARlGlPLGlIhhllYFIllaVL	....................................................h..hLllIllllLlLPFhh+tlE+NLEhFLhlM...Glh...AshlSth.....................hshcLl.cshps.lhhh..........Is.sVLlu.GLlFhh.h+s+lpphl.pt.lhctl...s.lclhlFlllllLGLhSSlITAIlAullLVEl.l.phhPL.c.RpsKl.clsVluCFuIG.hGAALTPlGEPLSTIslSKL.....p.A...-......F....h.YL.hchlGhhI.ls.ullhhulluhhhl.t+..t....ph....ps........hpt..........hp.t.p......Esl+c.................VhlRAhKlalFlhALpLLGsGFKPlIctYllclsstlLYWlN.h.lSAlLDNATLA..AAEIoPt..Ms.tQl+AlLhGLLISGGM.LIPGNIPNIIuAuK.....Lp.IpS+EWA+lGlPlGllhhllYalllFh..........................................................	0	13	31	32
+7686	PF07855	DUF1649		Protein of unknown function (DUF1649)	Fenech M	anon	Pfam-B_9402 (release 14.0)	Family	This family is made up of sequences derived from hypothetical eukaryotic proteins of unknown function. 	20.50	20.50	24.00	20.70	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.95	0.71	-4.57	11	256	2009-01-15 18:05:59	2004-08-25 16:18:47	7	7	211	0	187	241	2	158.50	30	73.51	CHANGED	lElhs-sppV+DlVcuILHTIhFHR..............huoltPp..opDhlDhThstlsssEL-phl-p+lsshlcplcsspsp.................................spGQIulpFa-K++++.............sW.F..........hp.................................u-EpVsWE.WTlcVslspscoEt-+tpsRcuhpc..................pLpcslhcIlplsN+c.DaIPPIsTpsps	.....................-l.h-.pplc-slt.u...........lLHTIhFHR................h.us.ltsp..sp-hl.-hTas......t.s.ss.s-L-phlcpclsphhctl.c...pss.ss.............................................hpGQl...slpFap....K....++p+.................W..F...............................................................s-Epl...sWE.Wslplplh....p..........p..s........c...p....-.........+ths+cthtp............................tLpctlhpIlphhN.cc.....-alP.hsopt.........................................................................	0	63	101	154
+7687	PF07856	Orai-1	DUF1650; Orai-1_Ce; 	Mediator of CRAC channel activity	Fenech M, Pollington JE	anon	Pfam-B_9685 (release 14.0)	Family	ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [1].	25.00	25.00	33.60	28.70	21.60	20.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.29	0.71	-4.70	15	268	2009-10-24 14:23:42	2004-08-25 16:20:09	7	6	107	0	171	238	1	183.50	52	64.56	CHANGED	p+aplpslppR+L-.uR..................tQLKAoSppSALLuGFAMVAhVElQhscspph....spuLLlAFussTollVuVcLhAlhloThlLssI..................-sss.htshps..sspoPHcphcha....hEssWtauhph...GlhLFLlplullsWlKFass................................................................hsAAhssTuIhlsssllalhaohphatshlt++tscps	............................s..as.psLSWR+L.LSR................................................................AKLKASS+TSALLSGFAMV....AMVEVQL-sspph.....P.sLLlAFosC.TTlL.VAVHLFALMlSTCILPsI.............................................EAVSNlHslsu.....lp-SPHcRhHha................IELAWuFSTsl.........GhhLFLsElsLlsWVKFhsl...................................................................u.tAAhsoTsIhlPssllFl.sFslHFYRSLVsHKp-p.t....................................	0	54	76	121
+7688	PF07857	DUF1632		CEO family (DUF1632)	Fenech M, Bateman A	anon	Pfam-B_9654 (release 14.0)	Family	These sequences are found in hypothetical eukaryotic proteins of unknown function. The region concerned is approximately 280 residues long. This family has been termed the CEO family for C. elegans ORF [1].	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.76	0.70	-5.13	6	180	2012-10-02 19:55:49	2004-08-26 09:34:15	7	7	72	0	127	161	9	207.00	32	68.02	CHANGED	GllAChlSslhFGShFVPlK+acouDGhFlQWlhShulhLVGllVauspGFPtFaPlAMLGGhhWusGNuhuVPIhssIGLulGhLlWsTssClsGWAsuRFGLFG.lssphPpsshLNYlGllllVVGGslFh.IKsp...spscscsoshphE..sshppc..sspcsSsh...c.....h.p..+p......RllshlhAlluGhhYG.hhsPlhYIpspsp....lYPsusppslsYlFSaahGIFlTSTllFlsYsIhp+NsPhlssp	.....................................................GhhushluhlhFGS.aVPlK..+hs..su....D..............G.h..............ahQWhhshulhl...........suh....l........h.h.h.................h.............t........s.....t.....F.......hPh.A.MlGGhlWus.....GNhhs.VPllptlGLulGhLlWuohshlsG..WssuR..FGh..FG..hp...p...s.t.....p...s.hL.NhhGhslsllu...shha.hh.....l..+sp........t...........p......p...p............t...........sh........t...................p..tpp....................t.....s..........................................p...................................................+h.h..uh.hulhsGhhaG..hsPh.hh.pp............hts......slsal..auah.Glhhsuohh...ahhYshhh+...t...h...t..........................................	0	58	75	113
+7689	PF07858	LEH		Limonene-1,2-epoxide hydrolase catalytic domain	Fenech M	anon	Pfam-B_15033 (release 14.0)	Domain	Epoxide hydrolases catalyse the hydrolysis of epoxides to corresponding diols, which is important in detoxification, synthesis of signal molecules, or metabolism. Limonene-1,2- epoxide hydrolase (LEH) differs from many other epoxide hydrolases in its structure and its novel one-step catalytic mechanism. Its main fold consists of a six-stranded mixed beta-sheet, with three N-terminal alpha helices packed to one side to create a pocket that extends into the protein core. A fourth helix lies in such a way that it acts as a rim to this pocket. Although mainly lined by hydrophobic residues, this pocket features a cluster of polar groups that lie at its deepest point and constitute the enzyme's active site [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.53	0.71	-4.13	7	167	2012-10-03 02:27:23	2004-08-26 09:46:28	7	2	124	7	43	472	122	120.10	39	83.09	CHANGED	ssshcsVpsFhsAhpcsDhcssltchhsssphapN.GlsshpGhscshshlcth....shsuhEhcIh+IAADGutVLTERsDthhh..Gs.hhphhVhGlFEVpss+IshWRDYFDl.shhctssc	.........................................................tshcsVpsFls.Ah..p..s..t...D..h.-...s...s.......s...s.lhs...-.................V....Y....p...N......V..u......h......s......s..l....+.........G.....t...c...t.s.t.p.h.lc.th.........pst..sG...F-.l.+.....I...H...+...I..u..A....D....G.s.s..........V.....L.......T......E........R.o............D...slh..h..........G.s.l.....+....lp..FWV..CG.V..F.E..V...c....D.G......+ITl.WRDYF.Dhhchh+u...ht...................................	1	8	30	36
+7690	PF07859	Abhydrolase_3		alpha/beta hydrolase fold	Bateman A	anon	Pfam-B_100 (release 15.0)	Domain	This catalytic domain is found in a very wide range of enzymes.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.45	0.70	-4.76	130	13075	2012-10-03 11:45:05	2004-08-29 17:28:14	8	147	3378	94	4994	21100	3681	191.50	20	57.99	CHANGED	llYhHGGGal...lGsh.sop..cshspplAptssshVlSV-YR...LA.PEa.aPAAh-DuhsuhpWlhpps.........................................t.s..hD...ss.+lsluGDSAGGNLAtslu..ltsccp........h.............lsutlLlaP...shs.............pt..tsh....t..tpt.h.l....s..tsthp.hhh.ch...Yl...s..sssts.cP.....hsuPl....hu....s...lss..LP.P.......shlhsuphDsLpD-uttYAc+Lp.t..sGVpVphh.phtGhhH.uFhh	..................................................................................llahH....G.G.......G...a.h.......h.u...s...h...pst................pth..h....p.....t......l............s..............t............t..............t.............s..............h......h......l........l....s............l...s......Y....+....................L........u...........P..............c.............t............................a...........P...........s.............s...........l........p.............D......s............h......s...........u.h.p....a.l...hpph....................................................................th.t....hc.......sp...p..l.s.l...s........Gc.S........AG..G..p..Lu.h.s.hs..........hhhp..pt......t.....t....................................................................t.s.h.l.l...h..h.P.....................hh.sh.....................t........p.h..........................t.p..............h.....h...........................s.......t......h.t..........h.....h....h....ph...............hh....s.........ttthp....p..................................h.h...s..P.h.......t.........s..................htt....h..P....s................................h.h..l..h...s.....u..t....h...D.......h...h.......s......p...s.......h...h...............h..p...t.....l.t..t...........ts.....h...............s..p.hh...h.........s...h...H.sh..t........................................................................................................................................................................................	1	1372	2820	4031
+7691	PF07860	CCD		WisP family C-Terminal Region	Yeats C	anon	Yeats C	Family	This family is found at the C-terminus of the Tropheryma whipplei WisP family proteins ([1]).	25.00	25.00	110.20	108.90	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.09	0.71	-4.71	2	5	2009-01-15 18:05:59	2004-09-01 16:41:52	6	2	2	0	2	5	0	110.40	83	6.06	CHANGED	hQpAK.........Pp.psh.E+...TPTESKGGGFWSKVGSGIAAPFKWIWHGITWPFRKLFGSRSEA.........................phP........phlssAVspF....................LpFL..	PS........HTQSAKPTEKPKEEK...TPTESKGGGFWSKVGSGIAAPFKWIWHGITWPFRKLFGSRSEAPSSTTNATGNTsGKTRVKRDT.ppPPEHPLKSVN-QIppVTsAVNNFQKSVLTSLKsFFTYLTDTA+LpFLp............	0	2	2	2
+7692	PF07861	WND		WisP family N-Terminal Region	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of the Tropheryma whipplei WisP family proteins ([1]).	25.00	25.00	362.20	362.20	19.80	16.80	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.88	0.70	-5.36	2	12	2009-09-11 19:29:28	2004-09-02 08:46:53	6	7	2	0	4	12	0	250.50	77	31.64	CHANGED	AhhL..SS.........psPPuLSLLSSVSpsSl.pSso+aopVS.sssp.sClosssssshhlDPlT..usotQT.oCssuhSs...pPtot....las.Yo-TsSYlYVPYIpss.l.LYY...KtsPSS.lshshoDhtTsa..........us-+VlShohososlhsLLTstNlaFa.pl.so.psplTVsl+hphcsshl.SshPuLRsS.aTaSLopPstslplDt.TGtlphS....olsspslTAhAlphsTuThlT..YhhDo.h.	LT..LLLLSSLQYETAFARQTPPALSLLSSVSSTSV.SSNTKYTRVSNTNTQEVCVTTNTNVSLLIDPVT..SSTKQTLSCTPSLSP...QPQTH....IYVPYTDTSSYLYVPYITNTHISLYYTDKKADPSSFLTFPHTDIATPY..........GDEKVlSITKTTTNLIALLTTRNIFFF.DIHVTEKPKITVPIHKQIDNTYL.SDIPSLRNSRYTFSLTHPNKDITIDRYTGQIHLS....SLPTSPITAIAIN+DToTHIT..YAlDo...ss...	0	4	4	4
+7693	PF07862	Nif11		Nitrogen fixation protein of unknown function	Yeats C	anon	Yeats C	Family	This domain is found in the Cyanobacteria, and may be involved in nitrogen fixation, but no role has been assigned ([1]).	22.90	22.90	23.10	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.17	0.72	-4.02	116	396	2009-09-14 15:19:10	2004-09-02 09:07:36	6	4	112	0	200	413	401	48.80	26	53.68	CHANGED	MStcp....LcsFLpcl.p.........sDssLppplpu..st.st-plltlApptGaphotc-lt	.............MS.cp....lctFlpcl.p..........sDssLpcplps......sp..ssccl....ls....l..A....pptGashotc-l..............	0	34	83	179
+7694	PF07863	CtnDOT_TraJ		Homologues of TraJ from Bacteroides conjugative transposon	Yeats C	anon	Yeats C	Family	Members of this family have been implicated in as being involved in an unusual form of DNA transfer (conjugation) in Bacteroides ([1]). The family has been named CtnDOT_TraJ to avoid confusion with other conjugative transfer systems.	25.00	25.00	25.00	25.00	24.40	24.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.38	0.72	-3.51	15	330	2009-01-15 18:05:59	2004-09-02 09:22:06	6	2	117	0	39	273	4	62.30	53	19.65	CHANGED	FMIIGIlGYFTlPTVuuWIIpAGGu.GuYu+sVNptut+uGssA.......uusuGAAhGssuG+lp..............u+	....FhlIGIlGYFTlPTVAGWIIQAG.Gs.GuYuR..NVNpsAs+uushA........uusAGAssGNhuGRl...th.......................	0	20	36	39
+7695	PF07864	DUF1651		Protein of unknown function (DUF1651)	Yeats C	anon	Yeats C	Family	This is a family containing bacterial proteins of unknown function.	20.40	20.40	20.80	20.70	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.40	0.72	-3.88	45	133	2009-01-15 18:05:59	2004-09-02 09:34:00	6	1	30	0	51	136	674	70.90	25	80.29	CHANGED	pGWLlssppphlhpFc...-ppohpt.s.tlhlcphchhs...upPslhcs+c+l.phcpAhctWccLlpsGWpcs.ps.hs	................sWLlssp...pphlhpFp.....spp.s.p..s.hlhlcphphhs......spPslh+spcch.ph-pAhchWppLhppGWpps.p..h........	0	2	20	42
+7696	PF07865	DUF1652		Protein of unknown function (DUF1652)	Yeats C	anon	Yeats C	Family	This is a family containing hypothetical bacterial proteins.	21.30	21.30	21.30	25.20	21.20	19.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.04	0.72	-4.37	16	126	2009-01-15 18:05:59	2004-09-02 09:42:41	6	1	42	0	31	125	0	67.00	32	78.74	CHANGED	hh-lRpllEpuFLPhpCpCohssstshTl+lh.-ssSGclpLhloGluhppLposRDlspLlspL+t-hs	........phppllEtuFhPhtCpsohssstoMsl+Lh.D.sSGcp.lslsGlshuplhoucDlscLltpl+p-h.....	0	0	0	20
+7697	PF07866	DUF1653		Protein of unknown function (DUF1653)	Yeats C	anon	Yeats C	Family	This is a family of hypothetical bacterial proteins of unknown function.	21.80	21.80	22.10	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.26	0.72	-3.79	54	591	2009-01-15 18:05:59	2004-09-02 10:42:42	6	8	565	2	154	512	59	62.70	44	59.86	CHANGED	sGhYRHYK.........G.s.YcVlulA+HSETcE..lVlYcsLYG-h..ulWVRPhsMFhEsVpl.-GpplP......RFphl	............................................shYRHa.K............G..shYpVlsl.Ac...HSETpE..pl..VlYpsLY.....u-h...ulWVRPhsMFhEp.V.h..Du..pphP......RFph...................	0	48	101	131
+7698	PF07867	DUF1654		Protein of unknown function (DUF1654)	Yeats C	anon	Yeats C	Family	This family consists of proteins from the Pseudomonadaceae.	20.90	20.90	21.10	23.50	20.60	17.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.47	0.72	-4.61	12	129	2009-01-15 18:05:59	2004-09-02 10:55:33	6	1	57	0	18	103	2	71.10	37	83.43	CHANGED	s.ouhE+LGhRlpchINuPsAQcpRhslIaRL-s-up--WEpllptlsEs-slsLsap.DDGuVpltWph.p--	..s..puY-tLuhRlQ+.lIsuPsAQpp+tsllhRhssEspccWsplL-pIuEs-slplshp.-DGo.VpltWph.........	0	1	1	12
+7699	PF07868	DUF1655		Protein of unknown function (DUF1655)	Yeats C	anon	Yeats C	Family	This protein is found in some prophages found in Lactobacillales lactis ([1]).	19.20	19.20	19.90	110.70	18.20	17.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.73	0.72	-3.98	2	18	2009-01-15 18:05:59	2004-09-02 11:17:53	6	1	12	0	3	13	0	54.70	80	86.09	CHANGED	aI..Dphth.hh-hL.A+ARHaIcls-hs.+LFDGpSVsTFThhtNshQVEh.cu	YILDDSIAFELMDLLKAKARHFIQLNEYVYRLFDGQSVVTFTTLENDIQVEMVKG.	1	2	2	2
+7700	PF07869	DUF1656		Protein of unknown function (DUF1656)	Yeats C	anon	Yeats C	Family	This family contains bacterial proteins, many of which are hypothetical.  Some proteins in this family are putative membrane proteins.	21.30	21.30	21.30	21.50	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.83	0.72	-4.18	72	1584	2009-01-15 18:05:59	2004-09-02 11:23:22	7	4	929	0	230	607	18	58.50	37	80.14	CHANGED	pElslhGlahPslllhhllAhslshllctlLschshaRhlWH.uLFcl...uLalhllus.l	.........lslhGlhF.PPlFhthlluh.slahll+RlLtshthhch.lWHPuLFsh....uLashlhsL.............	0	34	89	154
+7701	PF07870	DUF1657		Protein of unknown function (DUF1657)	Yeats C	anon	Yeats C	Family	This domain appears to be restricted to the Bacillales.	24.00	24.00	24.70	27.40	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.07	0.72	-4.28	27	523	2009-09-11 09:19:45	2004-09-02 11:26:35	6	3	182	0	90	296	1	49.90	36	36.63	CHANGED	pl+psl.AuLKuspAsLcsauLpTcsppAKphappsupphcpllpslpsRl	.........l+psL.AuLKusp...AsLEsFuLsTcsppAKphappsApphppIlspLpsRl.....	0	30	66	74
+7702	PF07871	DUF1658		Protein of unknown function (DUF1658)	Yeats C	anon	Yeats C	Family	This family of small proteins seems to be found in several places in the Coxiella genome.	25.00	25.00	25.20	34.20	22.70	24.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.92	0.73	-7.26	0.73	-4.18	7	73	2009-01-15 18:05:59	2004-09-02 11:31:08	6	2	6	0	19	34	0	30.10	42	65.46	CHANGED	sslKshcs.uhsp+PhtGssstahshhhh.	sslKshcs.uhsp+PstGNsssahshhhh.....	0	19	19	19
+7703	PF07872	DUF1659		Protein of unknown function (DUF1659)	Yeats C	anon	Yeats C	Family	This family consists of hypothetical bacterial proteins of unknown function.	20.70	20.70	20.80	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-8.03	0.72	-4.33	20	335	2009-01-15 18:05:59	2004-09-02 11:35:22	6	1	251	0	81	255	0	46.30	31	62.86	CHANGED	spshsosLhLchpsGls.ssGcPlh+s+oaspVKssAscpDlYsVApA	.................s...hstsLtLhhpsG.lD.psGcslh+s+sappVKssAs.-plasVApA..............	0	38	70	76
+7704	PF07873	YabP		YabP family	Yeats C	anon	Yeats C	Family	This family of proteins is involved in spore coat assembly during the process of sporulation [1].	21.40	21.40	21.40	23.10	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.79	0.72	-4.41	73	814	2009-01-15 18:05:59	2004-09-02 11:39:05	6	1	421	6	177	539	9	66.30	30	70.00	CHANGED	hsplolpu+pclhlpsh+slhsFsspclhlpTphGhLhI+GcsLplpplss-p..ltlpGpIpslpY.	...............clslhG+ppl.Ipsh+slhsFsscclhLp.TphGhLtI+GpsLplcplssEc..ltlcG.pIpsltY......	0	93	147	157
+7705	PF07874	DUF1660		Prophage protein (DUF1660)	Yeats C	anon	Yeats C	Family	This protein is found in Lactobacillae prophages.	21.40	21.40	21.60	21.60	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.75	0.72	-3.69	9	38	2009-01-15 18:05:59	2004-09-02 11:54:19	6	1	30	0	7	29	0	60.00	40	93.52	CHANGED	MKLhCKLFGHKW-....hsPhsphcs.aCtRC.........................saNRSDLDESENVFP...EKWLDKHMD	..MKLhCKL.FGHKWp.........ssshpphhc.tCpRC............htp..pt.....h.hNRSDLDES-sha....c.............................	0	2	4	6
+7706	PF07875	Coat_F		Coat F domain	Yeats C	anon	Yeats C	Domain	The Coat F proteins, which contribute to the Bacillales spore coat.  It occurs multiple times in the genomes it is found in.	23.80	23.80	23.90	23.80	23.60	23.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.58	0.72	-3.84	65	780	2012-10-01 21:25:29	2004-09-02 11:54:34	7	2	357	0	179	551	2	63.60	24	50.09	CHANGED	sDcsl.sschLsstKsssssYusAhsEsssPpLRpsltptlspshphphplaphhhpKGaYps.p	......sDpsh.ss-hLsshKtsspsYupslsEssssplRpsL.pphhsps.phptplaphhhpKGaYts...............	0	81	147	156
+7707	PF07876	Dabb		Stress responsive A/B Barrel Domain	Yeats C	anon	Yeats C	Domain	The function of this family is unknown, but it is upregulated in response to salt stress in Populus balsamifera ([1]). It is also found at the C-terminus of an fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus (Swiss:Q9ZA13; [2]). Swiss:Q93NG5 is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved (Swiss:Q9LUV2) and the domain forms an a/b barrel dimer ([3]). Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	21.20	21.20	21.40	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.10	0.72	-3.54	51	1481	2012-10-02 00:20:33	2004-09-02 12:33:13	7	15	921	48	686	1398	234	96.20	21	80.22	CHANGED	lcHlVha+h+csssspph..tph....hpshpsL........splsslpphp..hGtshsspp.....ttu.ashshhspFcshpsh.csYts.cP..........tHhphs.phhpshhp....phhshDaps	.........................lpHlVha+h+..psss....tpph......tph.......hpth..psL....................spl..s.t.l..t..p...hc....sG..hshs.sps...................pu.ashslhspFpstcsh.pt.Yts..HP..........t.Hht..ht..phh...ts...h.h..p.....phh.shDa.....................	0	173	439	571
+7708	PF07877	DUF1661		Protein of unknown function (DUF1661)	Yeats C	anon	Yeats C	Domain	This is a family containing bacterial proteins of unknown function.  Many of the proteins in this family are hypothetical.	25.00	25.00	25.60	25.60	23.10	22.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.87	0.72	-7.22	0.72	-4.45	9	52	2009-09-11 10:00:21	2004-09-02 13:59:39	6	2	3	0	9	48	0	29.80	45	32.42	CHANGED	LsR-hhssRA+TKKFSR+hh...RphsspotpFR	LsREhKpSRApTKKFS++hh...+php.p.t.hh............	0	9	9	9
+7709	PF07878	DUF1662		Protein of unknown function (DUF1662)	Yeats C	anon	Yeats C	Domain	This family contains bacterial proteins of unknown function. This domain belongs to the Ribbon-helix-helix superfamily suggesting these may be DNA-binding proteins.	22.20	22.20	22.30	22.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.52	0.72	-4.23	27	70	2012-10-02 18:44:02	2004-09-02 14:12:51	6	1	32	0	30	72	224	51.30	31	59.07	CHANGED	usps+SsRlpVlLPppls-cLpthAcpEuRosSs......hAclLIpcGlpRhtst	.....stscsshIpslLPcplsccLpthApp-uRosus......hAclLlpculpRtht.....	0	2	10	24
+7710	PF07879	PHB_acc_N		PHB/PHA accumulation regulator DNA-binding domain	Yeats C	anon	Yeats C	Domain	This domain is found at the N-terminus of the Polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA ([1]). The invariant nature of this domain compared to the C-terminal Pfam:PF05233 domain(s) suggests that it contains the DNA-binding function.	25.00	25.00	25.70	36.80	21.60	20.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.97	0.72	-4.24	47	465	2009-01-15 18:05:59	2004-09-03 09:55:21	6	3	457	0	198	441	191	63.80	56	33.74	CHANGED	plIKKYsNRRLYDTpoSpYlTL-cltphVhpup-FpVlDAKTG-DlTRslLhQIIhEpEs..tGp.s	...lIKKYsNRRLYcTpTSoYlTL-DltphVhcuE-FpVhDAKoG-DLTRolLhQIIhEcEs.tG..s.....	0	60	127	160
+7711	PF07880	T4_gp9_10		Bacteriophage T4 gp9/10-like protein	Fenech M	anon	Pfam-B_73396 (release 14.0)	Family	The members of this family are similar to gene products 9 (gp9) and 10 (gp10) of bacteriophage T4. Both proteins are components of the viral baseplate [1]. Gp9 (Swiss:P10927) connects the long tail fibres of the virus to the baseplate and triggers tail contraction after viral attachment to a host cell. The protein is active as a trimer, with each monomer being composed of three domains.  The N-terminal domain consists of an extended polypeptide chain and two alpha helices. The alpha1 helix from each of the three monomers in the trimer interacts with its counterparts to form a coiled-coil structure. The middle domain is a seven-stranded beta-sandwich that is thought to be a novel protein fold. The C-terminal domain is thought to be essential for gp9 trimerisation and is organised into an eight- stranded antiparallel beta-barrel, which was found to resemble the 'jelly roll' fold found in many viral capsid proteins. The long flexible region between the N-terminal and middle domains may be required for the function of gp9 to transmit signals from the long tail fibres [2]. Together with gp11, gp10 (Swiss:P10928) initiates the assembly of wedges that then go on to associate with a hub to form the viral baseplate [1].	25.00	25.00	25.30	25.20	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.74	0.70	-5.34	14	97	2009-01-15 18:05:59	2004-09-03 14:03:50	6	3	54	22	1	90	685	229.60	30	52.13	CHANGED	KphIclGslsssuTGDhLhcGGsKlNsNhsplYsthGDtc.................l.HAsGhap+aups.............hshsl.hGstasIDTo...sGs.lsVsLP+.....G...chGcslchhsssGShu....sNPlslhstuGDoIcG.ssss..hplspsasclpLhhsusu.......pW-Y....pl-slhssshssVscphh.IsssspTD.lslFs.pspYNsspLhVhtcss......sshhhpssp.hh.ls.sps...scVhss-h.ssl+ht...tsssDplh.lsah..sG..lhshhSS.tspsl+l	....................KphIslGphss-uTGDhLhcGGpKINsNFsplYsthGDsc..................h.ausGhapphsts.............................hssthGp.aslsTo...sut.lsl..plsc.....G....chscslchhss.uohs....spsltl..tssDolt...G.ssss.....h.lspsa.clplhhhuss.......hWpY....plpphhssc.ssltpp...ltststss.lsl...ht.tspYshhpl.Vhtpss......s...hptsp.hh..s.t.s......splhsh-h.tsh+ht....p.tDp.l..hsa...ss..l.thhps..t.th...................................................................................................	0	0	0	1
+7712	PF07881	Fucose_iso_N1		L-fucose isomerase, first N-terminal domain	Fenech M	anon	Pfam-B_11456 (release 14.0)	Family	The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis,  and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta-sheets with surrounding  alpha helices. Domain 1 demonstrates the beta-alpha-beta-alpha- beta Rossman fold. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting  residues, and domain 1 from the adjacent subunit contributing some other residues [1].	25.00	25.00	29.00	28.90	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.84	0.71	-4.73	17	960	2009-01-15 18:05:59	2004-09-03 16:01:50	7	3	940	15	59	415	11	163.90	70	29.68	CHANGED	tshP+IGIRPsIDGRchG..VRESLEtpTMpMA+ulAcLlpssl+assGssVECVIADssIGusuEAAtsuc+FpppsVslTlTVTPCWCYGoEThDMsPhhPKAlWGFNGT..ERPGAVYLAAshAuHsQ+GlPAFuIYG+-VQDscDpsIPpDVpEKlLRFARAulAVupM+G	.....s..hPKIGIRPsIDGRRhG..VRESLE-QTMNMAKusAsLloppL+assGssVECVIuDosIuGhAEAAACcEKFpppNVGlTITVTPCWCYGSET..lDMDPshPKAIWGFNGT..ERPG...AVYLAAALAAHuQKGIPAFuIYGHDVQDADD.T.oIPsD..VcEKLLRFARAuLAVAoM+G................	0	22	41	49
+7713	PF07882	Fucose_iso_N2		L-fucose isomerase, second N-terminal domain	Fenech M	anon	Pfam-B_11456 (release 14.0)	Family	The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage.  The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues [1].	21.30	21.30	21.50	21.40	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.03	0.71	-4.63	21	1038	2009-09-11 15:21:47	2004-09-03 16:04:42	7	4	952	15	63	438	21	167.00	60	30.95	CHANGED	+oYLshGuVSMGIuGSllss-FFpcYLGM+sEtVDhoEllRRh-ptIYDp-Ehc+AhtWlccps+..cGcDpN..Pcchpps.cpp....ct.ac.llKMhhIhRDlMtGN.+LtphGatEEuhG+NAlsuGFQGQRpWTDaaPNGDhsEAhLNosFDWNGhREPalhATENDoLNuluMLFs+LLTss	..........................KSYLShGuVSMGIAGSIVspsFFppaLGM+spuVDMTElpRRlDptIYDc.tE...hEhALuWsccsh+....G.DpN...............scphpcstE.pp....ct.hc.slhMsMhhRDhMpGNs+LA-hGhhEEulGaNAIAAGFQGQRpWTDpa.PNGDhhEAlLNoSFDWNGlRcPFVlATENDSLNGVuMLhG+.LTsT......................................................	0	24	43	52
+7714	PF07883	Cupin_2		Cupin domain	Bateman A	anon	Pfam-B_81 (release 15.0)	Domain	This family represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel).	21.50	21.60	21.50	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.47	0.72	-4.47	156	20335	2012-10-10 13:59:34	2004-09-06 15:00:03	6	127	4001	229	6298	26569	7119	70.00	18	38.76	CHANGED	hhhpltPGs.sss....Hh.H.ssp...EhhaVlpGc.hplp.ls...up...phhlpsGDshhhss.s..h.Hph.tN....susp.ssph...lslh	............................................h....h.sGt..ths.........+t...H..st.......p......ch.h..h....V...l...p..G..p...h..p....l....p...l.s.................sp.............pht..l..p..s...G..D...s........l..h...h.s.s..s.............h..Hth...ts.........s....pt...h.h...h...h..................................	0	1857	3867	5218
+7715	PF07884	VKOR		Vitamin K epoxide reductase family	Bateman A	anon	[1]	Domain	Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1 is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea [1]. Four cysteine residues and one residue, which is either serine or threonine, are identified as likely active-site residues [1]. In some plant and bacterial homologues the VKORC1 homologous domain is fused with domains of the thioredoxin family of oxidoreductases [1].	21.00	21.00	21.30	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.10	0.71	-4.32	38	864	2009-01-15 18:05:59	2004-09-06 15:44:38	9	18	670	1	380	845	319	134.20	23	51.63	CHANGED	tthhhhlhuslGllsShhlshpchshhp....hhshCsls...ssluCu..pVhsS.husl..FG.............hPsullGllsassll.shulhhhh...........phschhh.hslhhsshsuslhshaLhal.h..ahIp.uhChaChssaslolslhllshhts	...........................................t..hhhhhhuhlGlhhohhls.h...chphhp................h.shCs.ls........shh..uCspV.hs.S..uph....aG...............hPsuh..hGlhhaslhl.shuh.h...hh........................phsphhh...hhlhhu..s.h.hus..s.h..sh..aLha..h......ah.lt.shC.aChsshshshslhhhsh..t................................................	1	129	240	313
+7716	PF07885	Ion_trans_2		Ion channel	Bateman A	anon	Pfam-B_55 (release 15.0)	Domain	This family includes the two membrane helix type ion channels found in bacteria.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.87	0.72	-4.26	123	9163	2012-10-03 11:11:44	2004-09-08 16:19:51	11	158	2837	170	4782	12148	1623	81.40	21	22.30	CHANGED	hhlhhhhhhushhhhh..............t..h....shhs.ulYashsoloTlGYGD.l...sPt.sss.....t.......+lhs.hhhhhhGlshhshhlshhsphhhp	...............................................................hh....hhhh..uhhhh.h................................................t..t.h..s.hh....s...uh.Ya............s.hlTho..Tl...G..........Y......G..D..l.....sPt..oth..........u..................................+lhs...hhh....h.l.h.....G.l.s..hhshh.h.shlsphh..t.......................	2	1860	2647	3883
+7717	PF07886	BA14K		BA14K-like protein	Fenech M	anon	Pfam-B_4068 (release 14.0)	Family	The sequences found in this family are similar to the BA14K proteins expressed by Brucella abortus (Swiss:Q44701) and by Brucella suis (Swiss:Q8FVU0).  BA14K was found to be strongly immunoreactive; it induces both humoral and cellular responses in hosts throughout the infective process [1].	21.70	21.70	21.80	23.10	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.50	0.72	-4.27	58	605	2009-01-15 18:05:59	2004-09-09 13:46:19	6	5	152	0	174	430	7	30.90	47	18.05	CHANGED	sahpaCspRYRSYcPsssTY.sas.G.R+.C.	....HlpaChsRYRSYcspDsTYQPas.GsR+tCh.......	0	13	69	96
+7718	PF07887	Calmodulin_bind		Calmodulin binding protein-like	Fenech M	anon	Pfam-B_4579 (release 14.0)	Family	The members of this family are putative or actual calmodulin binding proteins expressed by various plant  species. Some members (for example, Swiss:Q8H6T7), are known to be involved in the induction of plant defence responses [1]. However, their precise function in this regards is as yet unknown.	21.00	21.00	21.50	22.10	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.87	0.70	-5.37	11	283	2009-01-15 18:05:59	2004-09-09 13:48:24	6	6	26	0	157	262	0	252.30	37	49.84	CHANGED	plpLtFhspL..phPlFTGuKlEucsGsslclsLlDssTs.....lssGst......SshKlEllsLcGDFsstpc.-pWTsEEFppp.IV+pREGKRPLLsGslpVsLps.Glusl.u-lsFTDNSSWhRSRKFRLGsRVsss...sGlRlpEAho.EuFsV+DHRGE.....................................LYKKHaPPhLpDEVWRLEKIGK-GAaH++LssptIsTVc-FL+hhshDss+LR.pllGssMSs+hWcshlcHA+oClLus.clalYp....spssslhFNslaEllGlhhsspahs..hcsLsphppshl...........cpLlppAYpphspl.ph-schhhshs	............................................................................................hpLpFhspl....sl.FTss+lpu-pusslclsL.hDssst.....hlssGs.......ushKl-llVL-G...DF....ss...cp....p...ps..W...T...t..--F...psp...lV..pt....RpGKcPLL..........s.........G.........-..l..lpLcp...Ghusl..s-lpFTDNS.S.a.h.RS.....RK...FRLGs+.ls....s....s.....tuh...Rl...pE....Aho.-sFsV+D+RG.E.....................................hhKK+aPPtL..pD-VaRL-+IuKc...............G........s.hH.+.........cLp................p......t...............tI.oVp-FLph.h..h...h..c.............p..cL..R....p..............lLG.....thS.s+hW-shlcHA+.sCslss...c.ha..hYh........ttpphslhFNslhphhGh.....h.s.tp.hhs...pplsp.pp..s..............pthhppAYpph.pl.tht.......................................................................................................	0	20	89	126
+7719	PF07888	CALCOCO1	CoCoA; 	Calcium binding and coiled-coil domain (CALCOCO1) like	Fenech M, Mistry J	anon	Pfam-B_4504 (release 14.0)	Family	Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1, Swiss:Q8CGU1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 (Swiss:Q61026), and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region [1].	30.00	30.00	30.00	30.00	29.90	29.70	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.79	0.70	-6.22	3	312	2009-01-15 18:05:59	2004-09-09 13:50:00	6	6	55	0	115	266	0	340.20	34	63.29	CHANGED	spp+tGVsFLNVA+TYlPNTKVECHYTIPsGpcsSoRDWIGIFKVssuoVRDYaTFVWAlsPEuss-GSsuHCSVQFQASYLP+PGsQpYQFRYVDppGsVCGpSssFsFuEPRPMDELVTLE-....EDuGsDlLLVVPKATlLQNQLEtuQ+ERNDLM+t+LALEG-V..................o-hRSRIppLEsALcpScccspELcEQaK-lsoScpphouERNlLssQcAEpppRILELEsDIQTlocKh..................pEp-+lLtthp-IcA-LEppKuELp...........................QRLK-pTlQh+Dp.spt.chQLElEsL+EcLRouQEhLuSSQQKAsLLGEELAShuSlRD+TIAELH+SRLEoA-lul+LS-LuL+LKEGpuQWuQERsuLpQSsEA-KD+IlKLSAElL+LEcuLQEERSQRcsLcsELupEKDuspVQLSEs+RELoELRSALRVLQKEKEQLQEEKQELL-YlR+LEtRLDKlADEKWsEDAs..lsEDccuulshosslDLoDS-DESPtDEu.SpcLuPsuLDEcscstSoPssP+Espc.VVIsQPAPIuPaLSGlAEDssS-	.............................hu.....tV.F.sVs+.YlPpsplpC+YTLs.hhhPpspDWlGIFK..........V........GW....sos.RDYaTFlWu.sh........P..-s..hspsoshpp.pVtFp....................u.YLP.p.s....ss..p.hYQF.sYV.spp.Gp.lpGsSsPFQ.....FR..s..p.s...-..L....l..shpp.................t.t.pDh.Llls...+....s.t.....h...p.........plc..c........pEpp-.....Lh...p......Lptph...........................tp.hppphtph....ptthtptpp...p........htpL.t.t..p..th........p........t..t.....h.......p.....Epp.............h...........p..........tc.........tch....hp.Lc....pp......thppp................................................t..............t.........p..................phpt.....t.....................................................pht.............p...hp................t......................................p.......................................................................................................................................................................................................................................................................................................................................................................................................................................ttt................................................................................	0	16	26	55
+7720	PF07889	DUF1664		Protein of unknown function (DUF1664)	Fenech M	anon	Pfam-B_4797 (release 14.0)	Family	The members of this family are hypothetical plant proteins of unknown function. The region  featured in this family is approximately 100  amino acids long.	30.00	30.00	30.00	30.40	29.80	28.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.67	0.71	-4.33	14	118	2009-09-11 16:08:29	2004-09-09 13:51:16	7	2	27	0	61	110	0	120.00	38	37.07	CHANGED	uoG.hshhll.ssslGAlGYGYhWWK............GhphsDlMaVT++shusAssslsppL-plp-slsusK+HLopRIpplDc+LDppp-ltcpspc-VstlppslssIpcDlcslppslpsLcuKlsplEtpQ	..........s..sshs.hllsssslGAl..GYuYhW.WK............GhphoDlMaVT+RshusAssslsKpL-pVssuluusK+HLo...pRIpplDp+l-cpt-lspthcc-V..stl+tslspItpDlpslpphVpsL-sKl.splEtpQ...........	0	14	37	50
+7721	PF07890	Rrp15p	DUF1665; 	Rrp15p	Fenech M, Mistry J, Wood V	anon	Pfam-B_9434 (release 14.0)	Family	Rrp15p is required for the formation of 60S ribosomal subunits [1].	21.60	21.60	22.60	22.10	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.04	0.71	-4.10	32	310	2009-01-15 18:05:59	2004-09-09 13:52:49	7	4	276	0	216	307	1	139.90	30	50.85	CHANGED	uausuhspILu...........o+htsssps..PILu+sKchh...cphps-cLEpKA................................................ct.hhpEK+phhp+sRV+s..........ls...............................phh-pE+pL+Kl...........Ap+GVV+LFNAVpssQhpsccthpct.ptpphh............................cchl...sc...lSKcpFLDll...............pu	...............................................................................uausuhscILs............pchspspps..slLu+sKphtt....cc....hp..p-c.lEp+s.......................................................................pt.h.tpcK+ph.ppsRl+ssls..................................................................pst-pE+pL++l...........Ap....+GVVpLFNAVpptQtps.p.c.t.h.c.cs.t.t.p.tppt.................................................pchl.....sp..lSKpsFL-hlp.u.........................................	0	72	115	177
+7722	PF07891	DUF1666		Protein of unknown function (DUF1666)	Fenech M	anon	Pfam-B_9387 (release 14.0)	Family	These sequences are derived from hypothetical plant proteins of unknown function. The region in question  is approximately 250 residues long.	25.00	25.00	33.00	32.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.81	0.70	-4.96	6	77	2009-09-10 15:06:31	2004-09-09 13:54:16	7	2	16	0	50	75	0	227.60	41	40.08	CHANGED	ppDLEhVYVGQlCLSWEhLaWQYcKAh-lhE...cD.ash+pYNpVAGEFQQFQVLLQRFVENEPFQ.GPRVpsYlRpRClh+shLQVPsIR.pDctKsKKssRcE....ppD.sIoospLsEIlcEohplFWcFLRADKccusl.slKuhptoQhp.....DssDlELhhplKpchQK................KE++L+-lhRSssCIlKKFpKpcpcp...sps.hFhutl-LKLVoRVLsMs+lsp-cLtWCpcKLs.........................KIshssR+..lphEsSFsLFPs	.....p-LEtsYVuQlCLoWEhLpWpYpphpchhp...........sss..p..ssp.pasplAtcFQQFQVLLQRFlENEPFE.G........RschYsRtRshh.pLLQVPph+.t-p...p-cpp.tpp......t.c.hIsuspllcIhEEoIpsFhtFl+sDKcpss....hhpshhpp..p..hp.....ssh-.pLltp.lppshpK.................Kch+LK-lh+stpshh++hhptp.......pchphhhu.lDlKlVoRVLpMscloc-QLhWCccKhs.........................Klph..h.pt+..lph-.sS..lhFP........................	0	6	33	42
+7723	PF07892	DUF1667		Protein of unknown function (DUF1667)	Fenech M	anon	Pfam-B_9631 (release 14.0)	Family	Hypothetical archaeal and bacterial proteins make up this family. A few proteins are annotated as being potential metal-binding proteins, and in fact the members of this family have four highly conserved cysteine residues, but no further literature evidence was found in this regard.	20.20	20.20	20.30	20.60	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.58	0.72	-4.29	35	405	2009-01-15 18:05:59	2004-09-09 13:57:04	6	5	308	1	112	341	7	80.60	40	59.44	CHANGED	sRGhcYAcpElpsPpRllTooV+lpsGc.hshlsVKTccPIPKchIh-sM+tLpplpVpAPV+lGDVllcNlhsTGlcllAT+	.............RGttYucpElssPpRllTooV.+.l..c..........uGp.hshlsVKTpcsIPKpplh-shctLpp...lpV...pAPV+hGDVllcslhsTGVDllAT+...............	1	63	88	101
+7724	PF07893	DUF1668		Protein of unknown function (DUF1668)	Fenech M	anon	Pfam-B_5066 (release 14.0)	Family	The hypothetical proteins found in this family are  expressed by Oryza sativa and are of unknown function.	21.30	21.30	21.50	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.58	0.70	-5.32	43	450	2012-10-05 17:30:43	2004-09-09 14:01:57	8	10	10	0	256	374	0	265.40	19	82.32	CHANGED	RRalaLllcstt.ts.....asl++lD...........................................s.stssssssthpthpLP.sshhph...................tshpFhsl.....sss+llus.....-ts.........sp...shlYDssspsVt.................shPs..Ltp.PKhhP..lulsl.................Gss.LY......lh-pssps..ss..........pFEsl....shp...............tttcsWsWps.....L......PP.PP.......Fststp..............lsuYAVV.....sG....spIhlooss.........................G........TYuFDTssp..p.....Wp+h...G-W.tLPFpGpAcYVs..EhsLWhGlussstt.....hl.sAsDlsusst........pP.hh..hthh........chtsP.....................hsupLlpL.G.uG+FCls+hhpst.................................t.stppttspphhshlTulcl...........................stspsspLchlp++up.pa	...............................................................................................h.phs.............................................................................................................hP.....hph....................hphh.h...........tstllsh........s.t....................tt...shlaD..sttt.....thh............................hPt.......h.t..sp..h...s...h.h.h...........................................................ssp..la......hhpt....................Fcsh...ht..........................ththp............lPs..P.P...a.h...............................ltuaslh......s....pp.lhlShtt...............................G........Tash...D......s..pt...t.....Wpph....GpW..LP.F..G...pu.ass..ch.t..hahGlstts............l.suhslss........................h.....................th...........................ts.lh.h.G...su.....paChhchh........................................................hh.h.hhth.......................................................................................................................................................	1	0	55	167
+7725	PF07894	DUF1669		Protein of unknown function (DUF1669)	Fenech M	anon	Pfam-B_9335 (release 14.0)	Family	This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.	36.60	36.60	36.70	37.60	36.40	36.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.84	0.70	-5.21	23	379	2012-10-02 13:01:53	2004-09-09 14:15:35	7	3	44	0	217	312	0	254.00	40	43.34	CHANGED	L--spsp.csstu....psphhYsEptRLAl-sLLpsG.cAapphLppEplhcFLSspElptlhpssph.pssscp...........................tt..sttpstssst-su.....SsTYaPttS.Dt-sP.sLDLGWPs..sssa+GsT+lslahQP..sh.cspssIKEllR+hIppApcVIAlVMDlFTDlDIhpDLl-Aup+RpVsVYlLLDpsslstFLcMCp+hplshpcl+...........NlRVRoVsGssahs+oGp+hpGplpcKFlLlDsc+VhoGSYSFoWosu+lcRs....hlplhoGplVEtFDcEFRpLYApSpsl	................................s.....t.hasEttRLAl-sLlptG.cAahphLppEph...hsFLSt.Elphlhpphpt.....t..s.st.t..................................t..t..s.t....s..tstsss........ShTYaP.tS.DhpsP.tL-LGWPt...psshpGhTcsslahQP...s....spt.sIK-hlRphIppA.ppV.lAlVMDhFTDlDIhpD.ll-Au.+.RtV.sVYlLLDptslphFLcMspchp...lp.t+..l..c...........NhRVRolsGssahs+oGp+.hpGplppKFlllDscpVhsGSY.S.FoWo.su+hcps....hlhlhoG.plVE.FDcEFRpLYAtSps..............................	0	8	29	86
+7726	PF07895	DUF1673		Protein of unknown function (DUF1673)	Fenech M	anon	Pfam-B_4746 (release 14.0)	Family	This family contains hypothetical proteins of unknown function expressed by two archaeal species.	22.90	22.90	23.10	23.50	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.56	0.71	-4.79	23	47	2009-09-14 08:49:41	2004-09-09 14:24:15	6	4	14	0	41	45	6	189.10	18	76.51	CHANGED	hhhh-pIKKLMGWCPNA+shEs.ppphs.psF-usstscuc.tpssshcssuhap+t....psphLlhshhhThhhh.lhls.hGlsh......hhLLhGhhlu...Lhhhlhs..................WKtphppa-ultcp.lhcsssKpph.....lhhlhhhlhhhhhhh..hh.t.h.tthshpsllSF...........................luGhhlh.hWlhYhQllYWEKKN+phlahcppps....pchYllsE+p	.......................................................c.I++hMGWCPsspt.ps.tpphs.t.hcht..ptst..psts.hs...thhp+h....psphLlhshhhohhhh..lhl..hulsh................hhllhGhhhs...Lhhhlhs....................a+p.hppac..shtph.lhpsp.+pph.....hh.hlhhhlhhhhhhh.......h...hs.phhhuh.............................hsuhhlh..hahha..hphhhacc..+pphhlhhppp.t.....t.hhh.tc...........................................................................................................	0	15	21	21
+7727	PF07896	DUF1674		Protein of unknown function (DUF1674)	Fenech M	anon	Pfam-B_4326 (release 14.0)	Family	The members of this family are sequences derived from hypothetical eukaryotic and bacterial proteins. The  region in question is approximately 60 residues long.	23.50	23.50	23.50	25.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.51	0.72	-3.75	75	599	2009-01-15 18:05:59	2004-09-09 14:35:58	7	4	563	1	312	536	163	65.50	37	65.31	CHANGED	Eu-pp+tt...tt.................................P.....tElG...G.scG.EPsRY......GDWEpcGRssDF	......................................................................tttt..t.......................................tpstP........tElG...G.s.cG.....EP.s..RY......GDWEhKGRssDF..........	0	89	167	248
+7728	PF07897	DUF1675		Protein of unknown function (DUF1675)	Fenech M	anon	Pfam-B_4280 (release 14.0)	Family	The members of this family are sequences derived from hypothetical plant proteins of unknown function. One member of this family (Swiss:Q9SFV5) is annotated as  a putative RNA-binding protein, but no evidence was found to support this.	20.50	20.50	20.60	20.50	19.60	20.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.09	0.70	-4.54	6	138	2009-01-15 18:05:59	2004-09-09 14:43:05	6	7	27	0	84	134	0	171.40	27	53.82	CHANGED	EIELsLGLSLGGpFGsD....h++s.+LsRSSSlssssshscs.....puushts.ph............sL.RToSLPsEoEEEh+KR+EhQoL+RhEAKR+RsE+...hsusts..............stush.pRccpsusshspssspsstuustssoSSuhsEhssts.stt.spstt.push..h.h.spts.tts..Pssspsppsspspsspcstcs.p.cpsust-sspshhpDMPCVoT+GDGPNGK+V-GFLY+Y.tptEEVRIlCVCHGoFLSPAEFVKHAGGscVs........+PLRHIV	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.phP.hV.ops...Ps....G+plpGhhY+Y..pt.ppVpIVCsCHGsahoPsEFVcHAGu....ps...........................................................................	2	10	49	71
+7729	PF07898	DUF1676		Protein of unknown function (DUF1676)	Fenech M	anon	Pfam-B_4779 (release 14.0)	Family	This family contains sequences derived from proteins of unknown function expressed by Drosophila melanogaster and Anopheles gambiae.	24.30	24.30	24.50	24.30	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.33	0.72	-3.74	64	512	2009-01-15 18:05:59	2004-09-09 14:45:18	8	6	30	0	390	577	0	109.70	18	36.55	CHANGED	+hlphlschh....pp...........sp.lplssGlplV+ssst....sttspstphtpt.....................hsphlhc+ltpalpoHsLplphsp.ttpt.h.............................t.htEuR.................t+Kh++....hhhPhlh	.................................hhphhschh....pp...........sp..lpls..culpll+ssss.....tttspshp.ptt.................................t.hsphlhc+ltpalpoHslplp.lsptttpttt.............................tshtEuR.......................h+Khc+.......hhhPhlh..............................................	0	103	147	331
+7730	PF07899	Frigida		Frigida-like protein	Fenech M	anon	Pfam-B_4728 (release 14.0)	Family	This family is composed of plant proteins that are similar to FRIGIDA protein expressed by Arabidopsis thaliana (Swiss:Q9FDW0). This protein is probably nuclear and is required for the regulation of flowering time in the late-flowering phenotype. It is known to increase RNA levels of flowering locus C. Allelic variation at the FRIGIDA locus is a major determinant of natural variation in flowering time [1].	21.30	21.30	21.50	21.90	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.69	0.70	-5.65	22	700	2009-01-15 18:05:59	2004-09-09 14:49:35	6	7	74	0	143	485	0	188.80	38	53.50	CHANGED	sspsssspsssts.......pLppLCtpMDucGLhpFl.pphcphs..slppElssAL+tusDPApLVL-ulpsha.sspts...tpphphhshcpsCllLLEsLh.............hps.lss.......sl+-cA+plAhcWKspl.....sspsspsh-uhuFLpLLusFulsupFcp--lhcLlhhsut++Q...sscLspuLGLs.-+h.............................................................................................................sshIcpLlspGcplcAlph...hathsLs-pFsPlslLKsaLpc.s+csst.hhptss.......................s...putspstc+-lsAL+uVlKClE-p+L-tcas.-s..Lpccl.tpLcctctp+++sspssp	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hstlhh...h.......h...............................................................................................................IVE.hlppGhpIEAlph...sasFGh.DKFs...sss.lLpuaL+..uKcs.pth.....................................................................................t.p...h..h.phhpt.p........................................ts...........................................................	0	11	76	106
+7731	PF07900	DUF1670		Protein of unknown function (DUF1670)	Fenech M	anon	Pfam-B_9559 (release 14.0)	Family	The hypothetical eukaryotic proteins found in this family are of unknown function.	25.00	25.00	25.00	26.20	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.33	0.70	-5.12	6	52	2012-10-04 14:01:12	2004-09-09 14:52:00	6	3	10	0	21	55	62	189.40	31	74.16	CHANGED	lhs-apFhsG..Vs+hlscplhphhcp.a..ssplcsGQllahulSs-Ess..GKslp-ppLlsVhLTLls.EDh-shpc.hthsElhcp+llRlspEAa-QsALLTpsDlAhLLshSpsTIS+clcpYcpc.GcllPTRGhl+DIGsuloHKphIlcLYLKGhpToEIARpTpHS.Eul-RYIKDasRVphLhpKGhss-EIphhsGlScplVcEYhEL	.....................................h..h.p.h.pthhphhpp..a.....pphp.GQhhahslstppss..GKshpphphhslhLolhs..-D.c.....hppth.t.pphpppplhRlhpEAacQsuhLTptDlA.hlLshSspTlp+plcphpcc.s.llPsRGph+.DlG.suloHKphl.lch.alc.s.hphs-IuRpTpHS.pAlpRYlpsFp+Vhhh.hpcshpspElthlsshoppLlp-Y.t..............................	0	16	19	19
+7732	PF07901	DUF1672		Protein of unknown function (DUF1672)	Fenech M	anon	Pfam-B_9698 (release 14.0)	Family	This family is composed of hypothetical bacterial proteins of unknown function.	25.00	25.00	25.20	25.30	22.60	24.90	hmmbuild  --amino -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.92	0.70	-5.41	7	690	2009-01-15 18:05:59	2004-09-09 14:53:00	6	1	200	0	7	359	0	239.30	62	91.09	CHANGED	ETKSVPEEM-ASKYVGQGFQPPAEKDAIEFAKKH+-chtKhGEQFFhDNFGLKVKATNVVGSGDGVEVaVHCDDHDIVFNASIPFDKshIcp-uShRSpDpGDDMSshVGTVLSGFEYRAQKEKYDNLhKFFK-NEcKYQYTGFTKEAIsKTQNsGYpNEYFYIos.shsLpEYRKYaEPLI+KsDcpFKcGMcpu+Kplshpups-lsTTLFSTKcNFTKcssh--lIchS-cl++h+phPcshplolQlucspINTp+s.YssppslEhtVapp....E	..................ETKSVPEEMEASKYVGQGFQ..PPA...EKDAIEFAKKH+.cchtKhGEQFFhDNFGLKVKATNVVGpsDGVEVaVHC-.DHsIVF.NASlP....h.KshI......cpcu..ShR..S..pDpGDDMShhVGTVLSGFEYRAQKEKYDNLYKFhK-NEcKYQYTGFTKEAINKTQNsGYpNEYFYITh.s.hsLpE.YRKYaEPLI+KsDcpF+cGMppu.+Kpls.hpu.ps.pssoTLFSppcNaoKcppl-s.VI-hS-plcch+.shPp.p.plolQlupphIsT.p+s.YscppslchtV......................................................................................	0	4	4	7
+7733	PF07902	Gp58		gp58-like protein	Fenech M	anon	Pfam-B_4289 (release 14.0)	Family	Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58 (Swiss:Q38355), a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H [1].	30.00	30.00	30.10	30.10	29.70	29.80	hmmbuild  -o /dev/null HMM SEED	601	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.77	0.70	-6.30	10	178	2009-01-15 18:05:59	2004-09-09 14:56:42	6	11	111	0	20	176	0	345.80	24	41.91	CHANGED	MSRDPTLTlDE.......SNLoIGuDGRsYYTFTA-sDspoV+LAsN.ClGTTRFNQLMIERGsKsTsYVAPVVVEGoGpsTGLFKs.......LKElNLELTDTcNSpLWuKIKLTNpGMLpEYacssIKoEIlpoAcGItpRIS-DT-+KL............................................ALIN-oIsGIRR-YQDADRcLS....uSYQAGI-GLK........ATMANDKlGLpAEIpsoAQ....GLSQ+YDsEl+pLSAKI....TTTSSGTTEAYESKLsGLRAEFTRSNQGMRsELE.........................ScISG..LpusQQoTApQISQEI+NRpGAVSRVQQsLDSYQRRLQsAE......cNYSSLTQTVpGLQScVSuPssplpSRhTQLts.I-Q+VTRscVpSlIspSGDSIhLAI.Kuth.pSKMSusEIISAINLNuYG.V+IuGcpIALDGNTTVNGAF..uAKIGEhIKL+ADQIIuGTIDAsKIpVINLNASSIV.......GLDAN.......FIKA+ItYAITuL......LEGKVIKARNGAMhIDLsSuphsFNpsApINFNos-NALhRpD.uTpTtFl+FoNussh....uapGus.YAthsIoS......suDGl-sssSGpFuGlRhaRhAouYppTusVDpsEIYGDsVlItcshNhshGaphp.s+sspllDhN.....h.A.u.hh..............hT	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................l.t........................................h..t.....t..th.....o.......lp.t....s...sp.....h.sl.........psthsus-llStINLss..tG...l.pIs...Gcp.ltls.GsThl..ss..sh............sutl.up..................lpAspIhsGolsAsclpshsl..sAspIs.....................tlsAs...............hhp.thh...t............................................................................................................................................................................................................................................................s.......................................................................................................	0	3	11	17
+7734	PF07903	PaRep2a		PaRep2a protein	Fenech M	anon	Pfam-B_4102 (release 14.0)	Family	This is a family of proteins expressed by the  crenarchaeon Pyrobaculum aerophilum. The members  are highly variable in length and level of conservation.  The presence of numerous frameshifts and internal stop  codons in multiple alignments are thought to indicate  that most family members are no longer functional [1].	25.00	25.00	32.90	32.80	21.10	19.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.68	0.71	-4.46	8	34	2009-01-15 18:05:59	2004-09-09 14:58:44	6	1	1	0	34	34	0	80.20	53	72.37	CHANGED	hsAlspWYhpCFGcs...Gp.tKVVKRLEEYauMCQMtpAsKREaG.+.splhhSEaALRRAFWW-GEWpGKPhSCFVTE+cAVCKVGcpphcFhVhssscGVYl+PEh.Lhp-WIKVAHRGsD	...................................................htEhG......h..-huL+tuF..ctt.hstshSCFVTE++AlCKVG-+hAsFYVFDTPcGVYL+PEIKLlp-WIKVAaRGs.......	0	34	34	34
+7735	PF07904	Eaf7	CT20;	Chromatin modification-related protein EAF7	Wood V, Bateman A	anon	Wood V	Family	The S. cerevisiae member of this family Swiss:P53911 is part of NuA4, the only essential histone acetyltransferase complex in Saccharomyces cerevisiae involved in global histone acetylation [1].	20.80	20.80	22.00	22.00	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.27	0.72	-4.01	19	246	2009-01-15 18:05:59	2004-09-09 15:29:00	8	3	222	0	178	256	0	90.30	31	35.27	CHANGED	EpEhpLF+ultp.aKPV...Glp+HFtMhsIh-clspt..............hscphsupslWcKLsphYsLctLD-hE.....pshshsscpc..........................-FsLPps-auc	..........................EhpLhcuhht.a+Ps............Ghp+HFpMlsIt-+hppp.........................................hscphsscsIWc+LsohYsLptL--pE...............h..shssppc..............................................................pFsLPpp.ht.t.............................................................................	0	52	92	145
+7736	PF07905	PucR		Purine catabolism regulatory protein-like family	Fenech M	anon	Pfam-B_4388 (release 14.0)	Family	The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, Swiss:O32138). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain.  It is similar to LysR-type regulators in that it represses its own expression [1]. The other members of this family are also annotated as being putative regulatory proteins.	28.90	28.90	28.90	29.80	27.20	28.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.22	0.71	-4.54	113	1282	2009-09-13 12:56:03	2004-09-09 15:29:15	6	5	619	0	359	1123	18	122.10	25	24.49	CHANGED	p-lLphsslpts..plluGp.....psLc+slcWVpls...Ehs.Dhssa..........LpGGELlLTTGhsltp.ssp...hppa...lcpLscsusuu..Lslths.hhp.p.lP..psllphAcphslPllplst...plsFsslsptltptlh	................................-lLphstLptt...pllu...Gc.....ps.L.s.p.s.Vphlplh...Ess...Dh...s.sa..........lpuGEL.lLToGhshpc.stp...........hppa...lcpLtp.tss..uuLslph.s.t.hht..plP...ppll...phAsphslPllplPt....shsasplhptlhp.h.....................	0	152	276	325
+7737	PF07906	Toxin_15		ShET2 enterotoxin, N-terminal region	Fenech M	anon	Pfam-B_4512 (release 14.0)	Family	The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri (Swiss:Q47635) and Escherichia coli (Swiss:Q47634). This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system [1]. Most members of this family are annotated as putative enterotoxins, but one member (Swiss:Q8X606) is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (Pfam:PF00023).	25.00	25.00	29.70	29.40	23.50	20.10	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.92	0.70	-4.94	8	670	2009-01-15 18:05:59	2004-09-09 15:30:05	8	1	306	0	7	369	0	250.50	38	50.79	CHANGED	o...hph........pphlppcphosps.pchlptcpK..PYhSc.KppsplNLNGps..s-psuchIhCRHLAuQYhhDhh..pssGKVsh.ccaSSs-pIpp+lslpcccphpsl..p.PuslYalsNscFGpslsshFppMcppucsspolhlposNHuMAlRL+IKcoppGp.+.aVVshYDPNtTssplRs...ssstsclpphSlccFls....ppthpsYu.pcsspphhs.psphPcppslh..t.......scls.sPLsssslhhhMstGhsctIpplhcplchhscpc..sphhplLsA+s	..............................h.....h...........pp.hs.......hp.spK......c.p..spl.pLNGpshF...s..tpP..p...stIhCRHluhQYh.D.h..pspG+lsh.ccYSSsEp..ltpHlshppcp.....ph.....hsLhpp.PtGppVlAstDFGhslphaFs+MpsNs....lShMuAILhssN.............HshuVRLRIKp..ospGphc.YVVSlYDPNsTNsplRh...spsppshthhSL.cFhs...ss.sh.pWuscplh..spsluIl..PhLPcpp.lhlhssh.......schs.sPlpPush.LlMuhG.spplhplh.plph....hschc....hhphlsAhN....................	0	2	5	6
+7738	PF07907	YibE_F		YibE/F-like protein	Fenech M	anon	Pfam-B_4781 (release 14.0)	Family	The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE (Swiss:Q9CHC5) and YibF (Swiss:Q9CHC4). Most of the members of this family are annotated as being putative  membrane proteins, and in fact the sequences contain  a high proportion of hydrophobic residues.	27.20	27.20	28.10	28.10	26.00	25.90	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.36	0.70	-5.19	89	1478	2009-01-15 18:05:59	2004-09-09 15:37:41	6	2	897	0	279	1002	29	239.00	28	70.23	CHANGED	ss.lhhlshlahhlllllGtppGlpul.luLhlshhllhhhl.lshhhtGhsslllsllhshlhhhloLhllsGhsp+ohsAhluTlhulhlshllshhhhphsplsGhs.EpsphLthhstt...lph.tlhhuullIuuLGAlhDluhoIuSulhElhppsP....ploh+pLhpSGhslG+DlhGThsNTLlhAahGuulshlllah..thshshspllNtchhuhEllpslsGuIGllLslPlTshl.suhh	...............lhllshlhlhlllllGtcpG.ltul.loLhlNhhllhhhl...l.hh.tGhshhllshlhsllhshlsLhllsGh.sh.+Th.sAhluTllush.lshhlshlhhthsphpG...hs..h...Ep...h...p.....lth...hshs....lph..tlhluslllusLGAlhDluloIuSulaElhpps.P....ploh+cLhpS.G.hplG+-lhGThsNTLlhuahGusLs..h..hlh.ah..p...sh..ohsphls.p.huhEllpslhGuIGllLolPlTshlsuh.h.............	0	119	208	254
+7739	PF07908	D-aminoacyl_C		D-aminoacylase, C-terminal region	Fenech M	anon	Pfam-B_13711 (release 14.0)	Family	D-aminoacylase (Swiss:Q9AGH8, EC:3.5.1.81) hydrolyses a wide variety  of N-acyl derivatives of neutral D-amino acids, in a zinc-dependent  manner. The enzyme is composed of a small beta-barrel domain and a  larger catalytic alpha/beta-barrel. The C-terminal region featured  in this family forms part of the beta-barrel domain, together with  a short N-terminal segment. The beta-strands of both barrels were  found to superimpose well. The small beta-barrel domain does not  seem to contribute to the substrate-binding site or to be involved  in the catalytic process [1].	22.40	22.40	22.40	22.40	22.30	22.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.14	0.72	-4.65	150	859	2009-09-11 00:09:33	2004-09-14 13:31:24	7	23	530	12	324	878	733	47.40	33	9.08	CHANGED	Ppp.lpDtuoas..cPhphAsGlctVlVNGtlsh.c.......sGp....sTG......spsG+llRps	........stp.ltDhuoa...p...cPpphupGIctVhVNGthsh.c..........cGp....hTu......spsG+hl+t.t............	0	114	222	284
+7740	PF07909	DUF1663		Protein of unknown function (DUF1663)	Fenech M	anon	Pfam-B_4106 (release 14.0)	Family	The members of this family are hypothetical proteins expressed by Trypanosoma cruzi, a  eukaryotic parasite that causes Chagas' disease in humans. This region is found as multiple copies per protein.	25.00	25.00	53.80	51.70	18.00	17.40	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.87	0.70	-5.97	2	85	2009-01-15 18:05:59	2004-09-14 13:33:30	6	9	6	0	4	85	0	202.10	76	97.85	CHANGED	htlpRcAVspcE......................RusRchlEtucAAh.DE..............LG.....-.hhssTHE+................uspshsAcEsttRGp.VGpE.............RcshsGhH...cpslcuEER...hsR+hLphtEstuhsplhp..........chR.hppp+t.phhtA.pDAths.httEER.......RshlsScE+hsRRhlEtG.hut.D...phGcEhusA......saphAlpthuhpEsAARtp.h.E.....YuhpRDul.Sp.psshpsLc+GpustVs..............ELhpEYcpsscchhsEtlhu..D........AsRtplVhEE.....sLH+ssl.oE....p+AVR+...............................slERsEttAhD.l..........................GEp.hSsshpR...........................slEsLttE	..........................................................................................................................................................................RcshhG.LH...RDAVDSEER...AVRRpLE+GEAAAVDELGE..........EYRSATHERsVEALAAEEDAARGQLVGEEREDshGLHRDAVDSEERAVRRCLERGEAAAVD....ELGE..EYtSA......THERsVEALAAEEDAARGQLVGEER............EDsaGLHRDAVDSEERAVRRCLERGEAAA..VD................E....LGEEYtSATHERsVEALAAEED........AsRsplVhEE.....................................................................................................................................................................	0	1	2	4
+7741	PF07910	Peptidase_C78	DUF1671; 	Peptidase family C78	Fenech M, Bateman A	anon	Pfam-B_9699 (release 14.0)	Family	This family formerly known as DUF1671 has been shown to be a cysteine peptidase called (Ufm1)-specific protease [1].	29.10	29.10	30.50	30.30	25.70	28.50	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.77	0.70	-5.22	38	453	2012-10-10 12:56:15	2004-09-14 13:38:51	8	18	236	3	315	461	3	187.60	30	42.79	CHANGED	upthhlhushshaHYtp.uhsDcGWGCuYRslQhllSWhht.......phh....s.....slPoIhcIQphL.chh.DK..ss........shhGo+cWIGosEsthllspL..slps+lhpht...............................................psu-l...sphhptltpaFp..sp.u....................sPlhltt..s........................shuhTIlGl-hp.......psuphphLlhDPHasus.ssh+hlhpcshsua...............+sssh..hp+...sphYpls	.............................s...hh.sshthhHa......hp..thsDp....G.....WGCu.........YRslQhlhSahh.t..........thh.................s........slP.ohhclQp..hl.psh.Dc..ss..........shhGo+pWIGohEst....hlLspl..sl......ps+llphp..................................................................................pssph...sphhc.lh........pa..Fp..st....s................................sPlhltt....s........................shu+TIlGlphp..................tss..p...hphLlhDPpasus...p.hp........hlhpp..shssh..........................+s..ssh..h.p...pt.Yplh.........................................	0	110	167	249
+7742	PF07911	DUF1677		Protein of unknown function (DUF1677)	Fenech M	anon	Pfam-B_4922 (release 14.0)	Family	The sequences found in this family are all derived from hypothetical plant proteins of unknown function. The region features a number of highly conserved cysteine residues.	25.00	25.00	27.30	26.80	23.00	22.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.33	0.72	-3.80	26	199	2009-01-15 18:05:59	2004-09-14 13:44:12	8	4	19	0	134	186	0	88.20	45	57.50	CHANGED	ElE.ss.+CECCGhpEECTspYItpVRscasG+WlCGLCuEAVp-Eht...R........psshslEEAlctHhuhCccFsuts...sPshp...lssuMRclLR+p	.......lEss+CECCGhpEECTstYIspVRs+atG+WlCGLCuEAV+-Eht...R.........ps.shshEEAlptHhuhCpcFps...s.....sP..slp...lspuMRplLR+p.............	0	12	72	108
+7743	PF07912	ERp29_N		ERp29, N-terminal domain	Fenech M	anon	Pfam-B_28781 (release 14.0)	Domain	ERp29 (Swiss:P52555) is a ubiquitously expressed endoplasmic reticulum protein, and is involved in  the processes of protein maturation and protein  secretion in this organelle [1,2]. The protein exists as a homodimer, with each monomer being  composed of two domains. The N-terminal domain  featured in this family is organised into a  thioredoxin-like fold that resembles the a domain  of human protein disulphide isomerase (PDI) [2].  However, this domain lacks the C-X-X-C motif  required for the redox function of PDI; it is  therefore thought that ERp29's function is similar  to the chaperone function of PDI [2]. The N-terminal domain is exclusively responsible for the homodimerisation of the protein, without covalent linkages or additional contacts with other domains [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.50	0.71	-4.20	3	92	2012-10-03 14:45:55	2004-09-14 13:52:51	8	4	73	13	52	132	2	117.60	51	47.87	CHANGED	lTs+GCVDLDolTF-KVlcKF+YSLVKFDTAYPYGEKHEAFTuLAhEssuoT-ELLlApVGIKDYGEp-Nt-LG-RYKlDKEsYPVIaLF+.GDu-sPVpa.PucG-VTlDuL++FLKupTuLYIGhP	........................................................spGslsLDploF.Kl.I.sK..Ka.l.LVKFDstYP.Y.G.EK..p...D...E..Fp...+lA.E.susuoc.DLLVAEV......GIp.D.YG-K..N.h-LuE+YKl-K-.saPVh.h.LFp.Gs...h-sPl.a.....sGslps.sslp+alKup..u..lYlGhP.........................................	1	15	18	33
+7744	PF07913	DUF1678		Protein of unknown function (DUF1678)	Fenech M	anon	Pfam-B_4886 (release 14.0)	Family	This family is composed of uncharacterized proteins expressed by Methanopyrus kandleri, a hyperthermophilic archaebacterium. 	25.00	25.00	35.50	141.40	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.35	0.71	-4.76	5	16	2009-01-15 18:05:59	2004-09-14 14:21:22	6	1	1	0	16	16	0	197.30	70	97.59	CHANGED	ss.+htlP...PcDPVEplRsLRVLhEshRRGphPhLtsoYRoVNGpshGPYY.ARWR.sSRaERGRTLYLGKSENESVpFlE.WLVSLsRtEVLELARH......LMRNLRSVLKoLLscVSuLPYK+...ARRVLAR.............GL..ALAFD.....ARPuuSP+.IRDVLEELPDRLESFllRTLGGWPAaYSS+Lc+llRuRRuSp-t+R.............tcVPDs..plcRhK.Rc	....p....HlP..IPpDPVERIRALRVLREVaRRG+KPSLEVTYRTVsGSTCGPYYVARWRRDSRa+HGRTLYLGKPENESVpFVE.WLVSLDRpEVLELARH......LMRNLRSVLKTLLTEVSsLPYK+...ARRVLAR.............GL..ALsFD.....ARPSpSPR.IRDlLEELPDRLESFhlRTLGGWPAHYSS+LcKlIRuRR+SLDG+H..............ElPDVtLELERWKLR.+..........	0	16	16	16
+7745	PF07914	DUF1679		Protein of unknown function (DUF1679)	Fenech M	anon	Pfam-B_4694 (release 14.0)	Family	The region featured in this family is found in a number of  C. elegans proteins, in one case (Swiss:Q19034) as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family (Swiss:Q9GUC1) is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins  (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.44	0.70	-5.84	20	190	2012-10-02 22:05:25	2004-09-14 14:22:31	6	7	8	0	178	1879	311	303.80	22	85.78	CHANGED	Lh-suDGLLpTHVTWcDVpcslpcphsTcAchGcs+phssIuDhpGFMS+luLlEs-Ws...t.psscpLPcKFsLKIoSpLslhslschhc.pssssascEc....hcthpphs+chHNREVshYKlLpKhN.pssl.hsKVYhhKpF-...--NcLKGalhhEalsslcshpha-slss--Lhsll+uIAshpAhuhpLo...--Eppph.tGt-a.c.hhpphhs-cslcshacphRphh.s...sE+lcEhlchhcpYh.plh.hcphsplschlGh.+sVLsHGDLWsuNlLaspps-GphplctlIDaQslphusPA.DLsRLhlosLSspDRRp+hpclL-paY-sFlcsL..ts.ctPYohcpLc-SYpLYFPhhulhlLPhlushl-sp...shspcct-ph+chshcKhtuLhEDlhchHc.sh	.....................................................................................................................................................................................................................................................................................Gh..S...hhhlt.pa.........t..hPtphhlK................hs................t.....h..h.p...........h..t...........t.h...h........hHN...pEsthY.p.....h.h.t.php............th.......hs..+....................h...Y.....hh..pthp.......pt....t.....h...t...G...hl..hh.-..h..h..t..s..h.....h.....h.....t..h.....ht....sh...s........pp..l...h..l.................hcs.........luthpuh.u.h.......p...............t.c..p........h...p........h.....................t..h.........t........h...h......t..p.......h....h....t...................................h....p..t....h.....h.....t..................h........t............................................t....p.h.......t......p........h.....h..........p.h..h....t...h..................................................................h.....p..........h........p.....p.....h........p....p........h..h........G...............h......................V........l...sHuDlhtsNhla.......p.....p....t........p....p....................................p..l......t...........u...................l....I..D...........a................Qh................sp...hGsss.D....lh..+.l.h.h.........s....h..........o..s.p...............p..R+.....t.th..ptlL...c.a....a...p...t....h...h.p....h.........................................p.........s........a...o....h....p.....p..l......p......p.....t.......Y...p......h.....h....h..s...h....h....s.....h...h..h.........h...s...h.....h........h..h..................................................t..p....thht-h.........h...........................................................................................	0	85	98	178
+7746	PF07915	PRKCSH		Glucosidase II beta subunit-like protein	Fenech M	anon	Pfam-B_9407 (release 14.0)	Family	The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1]. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown [2].  This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.	21.80	21.80	21.80	21.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.14	0.72	-3.18	104	586	2012-10-02 14:19:21	2004-09-14 14:25:08	8	29	264	2	365	860	7	84.40	27	19.03	CHANGED	upChh...ht.su.......haoYchCah.....cplpQhc............................tctsspphhLGpa..................................t..t.p.p...............tp..ttt...a.............hshtassGs.hC	............Chh...tt..pu.......WWoYEaCaG........+clcQaHt.....................................spchptpphh..LGpa................................................................................ptt.ph.tpp.ssp..............................t.t.....tp.....tt.t..tha..................................hsphhssGohC...................................................................................................................................	0	128	189	295
+7747	PF07916	TraG_N		TraG-like protein, N-terminal region	Fenech M, Mistry J, Coggill P	anon	Pfam-B_4841 (release 14.0) & Pfam-B_689 (release 23.0)	Family	The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein (Swiss:P33790).  This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions [1]. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly [1,2]. The protein is thought to interact with the periplasmic domain of TraN (Swiss:P24082) to stabilise mating-cell interactions [2].	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.73	0.70	-6.05	62	860	2009-01-15 18:05:59	2004-09-14 15:13:40	6	7	549	0	140	792	47	399.90	21	55.85	CHANGED	Elash.hsG.hlpssl.ulhshoGhhs....hs.shlhls...hhlulhhtuhshshptsh..tph.phhhsshllhhh..hhsP......psslphp-pp...............................sshstpsssVPlhhAhhtulooslstuhspshpssh.s.......................h+hhptphptphh.sP..............tltpplpcFhppChhhshth..tp.p.pshh........ss...sc.hshls..................pupsPhpshhhssspsss....................sh.TCpphas......sL+scl.hspss...........shhhhspthhsth.tsttt...shlpshl.spshphhht.u.pshsshhppshhhsshpsuhsp.....t...........husstuhtptshshtsttphstpsLPhhpshlhhhhhshhPlllhluh..h...hshuhshhthahhshha.LutWhshhhllshhsthhht..................sttshshh.shhshstsp.thshlhGhhhlslP.hhstslshuGspshuslss.hhususssuppu	...............................................................phahh.h.u.hlppsh.ul.hhhhuhhs.............hs..shhhhs...hh.l.tsh.h...uh.........s.ptsh..............h.h.th...hhsh...h...ll.hhh...hhhs.......hsslpl.st...................................sshs.ttsspVPlhhuh.hulsstl.stuhstshtphh..s.........................................hp.hp.h..ph...p....hhhh..ss...................tltpphtsahppChhhshhh....tp.t..pphh.........ss........s.hshlh.................................................................pp.psh.pth..sss......................................sh.oCpphhs.............tL+stl...tphp........................thhhhhp.thhsh...h...s.........................shhhth...h..s.pshph...........u..........tshpphhtps.hhssh.tp.uhsp.........................hssst..u.htttphsh..hshhphhhphl....Phh.shlphhhhhhhPllhhhuh.....h....phshthhthahhshha.lthW...hhlhshhhph.h.t.........................stsshsh........th.p.t..t.......ht.s...hGhh....hh...hlP.hhshh...hsh.u...u.htsh..sshhs...hhsss.tsst.............................................................................................................................................................................................	0	28	72	112
+7749	PF07918	CAP160		CAP160 repeat	Fenech M	anon	Pfam-B_9359 (release 14.0)	Repeat	This region featured in this family is repeated in spinach cold acclimation protein CAP160 (Swiss:O50054) CAP160 is induced during periods of drought stress; its precise function is unknown but it has been implicated in the stabilisation of membranes, cytoskeletal elements, and ribosomes. By acting as a compatible solute, it may reduce the toxic effects of cellular solutes that accumulate at high concentration during dehydration; it may also function as an enzyme that produces such a solute [1]. Other members of this family are also induced by water stress, abscisic acid, and/or low temperature, such as desiccation-responsive protein 29B (Swiss:Q04980) and CDet11-24 protein (Swiss:O23764).	25.00	25.00	28.80	28.10	18.40	23.30	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.79	0.72	-6.76	0.72	-4.32	7	30	2009-01-15 18:05:59	2004-09-16 15:00:16	6	3	9	0	15	40	0	26.40	67	7.17	CHANGED	ISsAsuslADKAsuAKNsVASKLGYGs	..ISSATSAIsDKAluAKNsVASKLGYGs.	0	2	11	12
+7750	PF07919	Gryzun	DUF1683;	Gryzun, putative trafficking through Golgi	Fenech M, Pollington J	anon	Pfam-B_9179 (release 14.0)	Family	The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun (Swiss:Q7Z392) blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex.	26.20	26.20	26.30	27.10	26.00	26.10	hmmbuild  -o /dev/null HMM SEED	554	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.70	0.70	-6.19	51	282	2012-10-04 00:47:01	2004-09-16 15:05:11	7	8	231	0	202	293	2	497.10	19	45.31	CHANGED	lplch.cchhsh..............................lpsshsFpps.phpsspshphplslpSss...ssPlclsplpltFssphpshhhptsp............................................th.s.tsltLhPspsphhshthhscp.....uGchclsulphplt.......................ppthphshshpsp..stttshhhhptppsst..phhlt......................tpstsplhsp...........................sPplplph................shpsshhssEhhsls........lpIpNpcctstpsshththh.........................s...t..sttsps.h.....t..pt.tt.hphslu.lptusptshplhlp..........shpssphtLplphhYpl...............................sssspsslhpsts...................hplshhpPF.phsa.....chhs+h+spsh..................s.............hhhpppahLpsphhshu..........sLhl.ph...............................slplhstssshhs.htppt......................psstlpspp.tt.ph..................................................................................................................................................................thtph.hsscpsssh.sslpIpW+R......................sps....ts.....shssoslslPcl..l.ss.hplhsph......sspstlss.lplchplcN.sotphhshplsh................-sScs..FhFSGs+......phslp.llP.....hSc+plpasLhshps.............Ghh..........................hlP.plplhs	...............................................................................................................................................................................................................h..lt..tph.sh.......................lpsphhFpp...phpsspshphplhlpups........stslphsplplthss..t.......s.hh.hpt..........................................................sttshpl.ssp.hth..hphth.scp.....stchchsslpl.lt........................ppthphhhshp....t..ttttt..hhpttps.t..ph.hh.................................tt.hh..lhsp.....................................splplph.......................................tht.s.hhssEhhsls........lplpspc.ct..hps.hh.hhhh..........................................t..s.tspsh.............s.tp....t...hths..lupltsspphphh.lhlp............s.pssph.l...lphtY.l..................................tpp..s.h.h.psts.........................hplthh..PF...t............chh.phhsp.h............................................................hhhp.....ahLhsphhshu...............................sL.l.s..........................................plplh.st.s....shtp..tp.s.................................thhltstp.tttth...................................................................................................................................................p.shtst.ps.ssh.sphhlpW+R..............................ss.ts.........................hsposlslPcl..l.......t..hpl.sph...........ss.shl....tts.....htlphplpN..oshh.shpl.s.h................................-sS-s......FhFSG.K...................................p.hslp.llP.....hocpphhapl...hPhhs..........................Gh............................hP.plpl..........................................................................	0	66	109	164
+7751	PF07920	DUF1684		Protein of unknown function (DUF1684)	Fenech M	anon	Pfam-B_9328 (release 14.0)	Family	The sequences featured in this family are found in hypothetical archaeal and bacterial proteins  of unknown function. The region in question is approximately 200 amino acids long.	25.00	25.00	26.20	25.90	24.70	19.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.98	0.71	-4.34	59	312	2009-01-15 18:05:59	2004-09-16 15:12:52	6	2	229	4	161	351	127	142.30	35	56.67	CHANGED	h.psFpGLsaashDssaplpA...paps.........hsss.....................cshthtoss..GtttphhphGplpFpl....sG.pphpLpsap........thsstLFlsFsDtTsGp..poYuuGRYLphphsssp.u.........p.....lsLDFNpAYNP.CAYsstaoCPlPPtpNcLslslpAGEKp	..........ppFpGlshashDspaplpA...paps.........h.s.ss.....................cslslssss..Gt.ppph..tsGplpFph.......sG..pphpLpsht..........ttsssLalsFsDtToGp....poYuuG....RaLphshsssp.G................plslDFN+AaNPsCAaos.thsCPlPPspNpLslsVpAGEK......	0	54	121	154
+7752	PF07921	Fibritin_C		Fibritin C-terminal region	Fenech M	anon	Pfam-B_31175 (release 14.0)	Family	This family features sequences bearing similarity to the C-terminal portion of the bacteriophage T4 protein fibritin (Swiss:P10104). This protein is responsible for attachment of long tail fibres to virus particle, and forms the 'whiskers' or fibres on the neck of the virion. The region seen in this family contains an N-terminal coiled-coil portion and the C-terminal globular foldon domain (residues 457-486), which is essential for fibritin trimerisation and folding [1]. This domain consists of a beta-hairpin; three such hairpins come together in a beta-propeller-like arrangement in the trimer, which is stabilised by hydrogen bonds, salt bridges and hydrophobic interactions [1].	20.40	20.40	20.40	21.10	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.75	0.72	-4.07	9	39	2009-01-15 18:05:59	2004-09-16 15:16:02	7	3	37	32	1	56	4	96.60	34	16.66	CHANGED	hsphspslpD.lpsclGsssSGlpusslphsstl.Gssssss.slpccGlppolKs.psslt..........................G.......hls-ssssG......phYhcccGtWsplssh	..................sthssslQs.lQs-IGNssoGlpGpllpLss.ltGsNssus.sV-c+GlpsolKs.psshs....................................G.......hls-sPpDG......phYsR+cGtWs.lss.................	0	0	1	1
+7753	PF07922	Glyco_transf_52		Glycosyltransferase family 52	Fenech M	anon	Pfam-B_2778 (release 14.0)	Family	This family features glycosyltransferases belonging to  glycosyltransferase family 52 [1], which have alpha-2,3- sialyltransferase (EC:4.2.99.4) and alpha-glucosyltransferase  (EC 2.4.1.-) activity. For example, beta-galactoside alpha-2,3- sialyltransferase expressed by Neisseria meningitidis (Swiss:P72097) is a member of this family and is involved in a step of lipooligosaccharide  biosynthesis requiring sialic acid transfer; these lipooligosaccharides  are thought to be important in the process of pathogenesis [2]. This family includes several bacterial lipooligosaccharide sialyltransferases similar to the Haemophilus ducreyi LST protein. Haemophilus ducreyi is the cause of the sexually transmitted disease chancroid and produces a lipooligosaccharide (LOS) containing a terminal sialyl N-acetyllactosamine trisaccharide [3].  	21.00	21.00	21.40	21.40	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.92	0.70	-5.36	16	318	2010-01-08 16:41:35	2004-09-16 15:19:39	6	3	241	4	28	224	7	254.60	24	82.76	CHANGED	ppphhhlhhsssts.chshhhcplppps.pshhhppsppp.ph......hhhhhlc.phhp..tchhcplahuN.splhhphhLsth....phhsh-DGhsNhpppshhhtpp.thh..............t++lhphhlsschsl.chhp.pKh+as.hKs...pcNhh....ppsphlslhp...pplpshpsss......slLlsQ...Plhp.D............ccEp....Ichhcsllpcashp....hhhPHPR-shchs..hhhlsscllhEsY.hcllph..hpthplhThFSosslshhspss.hclshl+sph	.................................................................................................................h.pph.hlhh..sps.s.K..phahp..plt..h..s.p..c..s...hh.tstphpphh.h........hhhhhK..plhp.........pphc.pla..hA.shch.hhphh.LSph..t.c....lp..TFDDGosN..l..ppsh.h..ht.pp...hht........................tp+lhp...hhhs.p.c..h.sls...chh...phspt+aola.s...hpNlh....cptphl...L.hc........t......t.lssppss.........hplLLup....P.h.p..s...................cccp.....lph.hpchlcp.hshc........hhhPHP...Rps...hchp..t.lhhl.s.sph....l..hE-hhhc.h..lcp.......hhphclashhSosthsh...shss..hcshtlps..................	0	5	9	16
+7754	PF07923	N1221		N1221-like protein	Fenech M	anon	Pfam-B_9309 (release 14.0)	Family	The sequences featured in this family are similar to a hypothetical protein product of ORF N1221 in the CPT1-SPC98 intergenic region of the yeast genome (Swiss:P53917). This encodes an acidic polypeptide with several possible transmembrane regions [1].	21.20	21.20	22.60	22.10	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.84	0.70	-5.57	26	320	2009-01-15 18:05:59	2004-09-16 15:25:12	8	8	225	0	215	308	0	276.60	28	32.65	CHANGED	pPshcFpYuDspshscElsEWFsYs..-hs.hhts...+ssF-ccap.a.............pWpctshtpc+sahtpllssLpp.s.thttR..hcsLpslhYluhGsaupss..............................ScspQlphh+pNshLLhphushtsLhplLsphhc.............pstsspssssshsths..........pp-ltllLTlhYlhlpssppp..pspsppphhlcshltsLtcP......sLhshLhchIs..+hRWssssshPl+......................pllLLlWKslLLtFGGpcpLccsKptlctthslp..........t.tpsppsshlTsSPLDYphFRp-Isu+YPsassP..pshl......Ph-h-N	.............................................................................................s.ssh-FpYsDss.shttEls.EhasYs....-h...phhhs....ppsFEppap.....t................................pW....chsp..pppcs.......ahh..pllc..tLc...s.s....stptR........hcshcsllYlspGs.au-ss..............................oc.sc.hphh+hNshLLhp..hGshsslh-lLpht.h.-.............................................pstssss..s.hchss.hs.....................................hscss-LpllLolh....Y.lhlEsh+pc..........tt.st.tth.hpshhtp..Ltps................................shshhLhshls..+a.p......s.puspaPh+......................+llLLLWKslL..hsh..G....G.hc.pLpphKtthcthhuls............................................t..pu.sss...sshsss.l-.p..................................t....................................................	1	55	96	163
+7755	PF07924	NuiA		Nuclease A inhibitor-like protein	Fenech M	anon	Pfam-B_43172 (release 14.0)	Domain	This family consists of protein sequences that are similar to the nuclease A inhibitor expressed by bacteria of the genus Anabaena ((NuiA, Swiss:Q44296). This sequence is organised to form an alpha-beta-alpha sandwich fold, which is similar to the PR-1-like fold.  NuiA interacts with nuclease A by means of residues located at one end of the molecule, including residues making up the loop between helices III and IV and the loop between strands C and D.  The mechanism of inhibition of nuclease A by NuiA is as yet incompletely understood [1].	20.50	20.50	20.70	38.60	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.38	0.71	-4.25	6	25	2009-01-15 18:05:59	2004-09-16 15:30:56	6	1	21	3	12	30	0	128.40	35	95.48	CHANGED	TpsspshLcpLcpAocGLLFMSEoDaPFpsFhW.sshhsloPEpVLptsscs.DssVpslslDsFFusATT.p-WasscEpsTlppFQpLl-TLKssLp-lpVYRlG-lplDVYIlGcsssGsLAGLpT+VVET	.....................pphhcpLcpAocGLLahSES-YPFElh..hW..tsttslo.spplhphsGhs.sssVcplslDpFFpsssspp-Was-tppsssp+FQpLlpsLKssL..schpVYRl.GplplDVYIlGcsssGslAGlpTKVlET........	0	4	9	12
+7756	PF07925	RdRP_5		Reovirus RNA-dependent RNA polymerase lambda 3	Fenech M	anon	Pfam-B_9372 (release 14.0)	Family	The sequences in this family are similar to the reoviral minor core protein lambda 3 (Swiss:P17378), which functions as a RNA-dependent RNA polymerase within the protein capsid.\	     It is organised into 3 domains. N- and C-terminal domains create a 'cage' that encloses a conserved central catalytic domain within a hollow centre; this catalytic domain is arranged to form 'fingers', 'palm' and 'thumb' subdomains.  Unlike other RNA polymerases, like HIV reverse transcriptase and T7 RNA polymerase, lambda 3 protein binds template and substrate with only localised rearrangements, and catalytic activity can occur with little structural change. However, the structure of the catalytic complex is similar to that of other polymerase catalytic complexes with known structure [1].	17.30	17.30	17.40	17.30	15.50	15.40	hmmbuild  -o /dev/null HMM SEED	1271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.26	0.70	-14.17	0.70	-7.18	3	118	2009-09-10 15:58:44	2004-09-16 15:38:12	6	1	33	6	1	75	0	466.00	63	99.55	CHANGED	LFNALPspLQpLSLALSGppPLTD+IFEsAAcAWHVpPRSpsYKLLDHIPFSosVV..IPPSIYsuhsWScYaAlssspVlRVsThsuPDDVYVPNSsIuPLLoPL+TIP-YGpLHPAIENDAo-hGsspARhASTFaKIASSQARQVKlDPpRFLtFLLVopAuPRVPSGVloDQPshhDPopSPALaAIWQIMQ+YKlsGsYYAPALVVsoGAlWWIPPPG+RNsVoVQaLLTDLINLAILAasTcLSPoLEhsGVplYL+AASSsSYAasLLchKSIFPsLSLHSMYRstEFGGKCPsIEWTEPRScYKF+WhGVTQLa-GLRPpoPSpDsKALElhcKYGLsDVu+lII+cR+sHPRHsaDSVRFVRDVMALTSGMYLVRsPTMSVLREYSQoP-IK-PIPPcsWTGPVGNlRYLpDospGPARHLYcTWhtAARQlAtDPpTHDPLsQAIMRoQYVTARGGSSAALKpALtsosVsLPDFcGosVK+SSKIYQAAQLA+luFppLIsAIhA-VTMGIRNQVQRRARSIMPLNVPQQsVSAPHTLVANYINKHMNLSTTSGSAVpDKVIPLlLYASTPPNTVINVDIKACDASITYsaFLSVICGAMHEGF-lGssutPFMGVPSSIVsDRRssuAPYuRPISGLQTMlQHLA+LYpAGFSY+VsDuFSSGNcFoFPTTTFPSGSTATSTEHTANNSTMMEaFLsVauPpHsKSuoLKRIlKDMTIQRNYVCQGDDGlLIIPcpuAuKISuEDlsELLELLcKYGctFGWsYDIDaSDTAEYLKLYALFGCRIPNlSRHPPVGKEYAuPpT-EIWPSLlDIlMGpFaNGVTDsLpWR-WLRFSWAFACauSRGua+shpGpSVu.AQYPhWSFVYhGLPPILLPGQTPFIaSsYMPsGDQGMFSILstWRDaLTu+AooshPPL+RsHPVWGLADVPSLLS-lGVYpGYaAAQlsRRPcPSP-sAss-SlEQhTuALS-YLhpDPsLKuRVlRGRssWERLosoauuslsSRVPSLFDVPsKWltAGRDA-KPsPSuVA-MhcoLpRAtR+Sp+SFSRLLELYL+VHV+LGEulPLAVDP-VPpVAGADPLNDDHWaKhTSLGPIsQSTRKYFupTLFVGKTVSGLDVEAVDATLLRL+ILGA-PEAapAhLsGIGMSDSEAHpIAG+ISLADAQlVQLARVVNLAVPSSWMSLDFDohI+HHuYshpPGIocsSTclR-RuuWlsuILRLLCAohAMTssGPVssuhVo-IDGGusALuGsLRsWMRDV	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GltuscPISGhQsMhQaLuKLYpRGFpYpVsDsFSPGN.FTHhTTTFPSGSTATSTEHTANNSTMMEsFLTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVsSETI..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	1	1
+7757	PF07926	TPR_MLP1_2		TPR/MLP1/MLP2-like protein	Fenech M	anon	Pfam-B_9285 (release 14.0)	Family	The sequences featured in this family are similar to a region of human TPR protein (Swiss:P12270) and to yeast myosin-like proteins 1 (MLP1, Swiss:Q02455) and 2 (MLP2, Swiss:P40457). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores [1,2,3]. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments [1], and is implicated in nuclear protein import [2]. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex [2]. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity [4].	30.00	30.00	30.00	30.10	29.90	29.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.87	0.71	-4.41	29	251	2009-09-11 18:57:06	2004-09-16 15:44:10	7	8	210	0	170	250	3	131.80	28	6.62	CHANGED	hppphsplps-lpphppptpphpp...phpphppDlcpQschsppAQpp....YEpElhpHucs.sppLppl+pphpphppphspLcppscpspspL.................................................pppcpsWppp+ptlcpElsphppRh--LppQNpLLHsQlEsls	.................h.ppphsplpsElpchhpctpptts...ptpptppDlppQuclApcAQpc....YEpELhhHAps.sctLpth+pp.......hsp.......hp....pphppLcppspsAcspL.........................................................................................tppcto...WpEpcptLccElschppRp--Lp..pQNpLLHsQlEsl....................	0	52	89	138
+7758	PF07927	YcfA		YcfA-like protein	Fenech M	anon	Pfam-B_2914 (release 14.0)	Family	The viral, archaeal and bacterial proteins making up this family are similar to the YcfA protein expressed by E.  coli (Swiss:Q9F561). Most of these proteins are hypothetical proteins of unknown function.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.97	0.72	-4.05	255	2133	2012-10-01 21:18:35	2004-09-16 15:49:37	7	4	1365	1	556	1700	149	54.70	24	71.59	CHANGED	hc-lh+hLp.ph.G........a..thh..ct.p.GSHhtap+ssppt..........hsls...H..sppc.lthstl+...pl.l+.ps	..................p-lh+hLp.pt.G........ahhh...ct.p.GSH.h..pappssppt..............hslP....H..stpc.lptttl+......pIh+........................	0	167	380	484
+7759	PF07928	Vps54		Vps54-like protein	Fenech M, Finn RD	anon	Pfam-B_9294 (release 14.0)	Family	This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog  (Swiss:Q9JMK8), the human homolog (Swiss:Q86YF7), and  the mouse homolog (Swiss:Q8R3X1). In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex  that is involved in protein transport between Golgi, endosomal, and vacuolar compartments [1]. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs [1].	20.90	20.90	20.90	22.10	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.64	0.71	-4.03	17	311	2009-01-15 18:05:59	2004-09-16 15:52:26	7	10	251	4	226	328	4	128.50	38	12.82	CHANGED	cspsahlssssLhllphlp-YhphhsphPslss-hhspll-h..........................L+hFNSRssQLlLGAGAhcsuG.LKsITo+pLALuSQsLphllthlPhl+thhpth.......t..hhtpac+lppDappHpsEItsKLluIhs-Rh	.................................................t.tppahlss...oslhllchlt-Yhphh.s..slPs...h...ss-hhsplh-h..........................L.+hFNSRssQLlLGAGAhp...s.u.G.LKsIToKpL...............A.LuSpsLphlht.h....IPh.................lRphhctp....................s.p.p...........s..h..........h.tcFD+..lp+sYp-H.spIpsKLlsIMssh.h.................	0	79	126	185
+7760	PF07929	PRiA4_ORF3		Plasmid pRiA4b ORF-3-like protein	Fenech M	anon	Pfam-B_4929 (release 14.0)	Family	Members of this family are similar to the protein product of ORF-3 (Swiss:Q44206) found on plasmid  pRiA4 in the bacterium Agrobacterium rhizogenes.  This plasmid is responsible for tumourigenesis at  wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process [1]. Other proteins found in this family are annotated as being putative TnpR resolvases (Swiss:Q9LCU7, Swiss:Q50439), but no  further evidence was found to back this. Moreover,  another member of this family is described as a probable  lexA repressor (Swiss:Q7UEI4) and in fact carries a LexA  DNA binding domain (Pfam:PF01726), but no references were  found to expand on this.	26.60	26.60	26.80	26.60	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.08	0.71	-4.87	18	780	2009-01-15 18:05:59	2004-09-17 17:08:24	6	17	653	2	251	715	156	155.20	21	60.93	CHANGED	ssplapL+lsLpsspPsIWRRltVPtsloLspLHpVlQssMGWpssHLHcFphs.sppYsh...........s....................s.s.ss.s..hspsphpLspllt..ttscshpYhYDFGDsWpHpIplE+hlsttsssphPh.ClsGptA.sPPEDsGGhsGYpchL-hlscPc+........cap-hhcWhGc.........F-sptFshccls	..................................................h.hpl.l...........t.s.l..aRc.l..lssshshtpLH.t.slptuh.s.a......p......s......s....Hhap.Fhhs......stpast....s.......................................................................................h...s....s......s.t.s........h.t..pps...pLsplh...........pttp...c..............hhYhYDFGDpWpaplp..................lp..c..........h........t.........p............t.........s.......t.......hsh..h..lput..s.......s...sP.p..s..s....................................................................................t............................................................	0	89	173	216
+7761	PF07930	DAP_B		D-aminopeptidase, domain B	Fenech M	anon	Pfam-B_29283 (release 14.0)	Domain	D-aminopeptidase (Swiss:Q9ZBA9) is a dimeric enzyme with each monomer being composed of three domains. Domain B is organised to form a beta barrel made up of eight antiparallel beta strands. It is connected  to domain A, the catalytic domain, by an eight-residue sequence, and also interacts with both domains A and C  via non-covalent bonds. Domain B probably functions in maintaining domain C in a good position to interact with domain A [1].	21.40	21.40	21.40	23.20	21.30	20.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.90	0.72	-4.25	2	66	2012-10-02 21:13:33	2004-09-17 17:09:08	7	2	65	1	6	26	0	87.40	75	17.05	CHANGED	sucssRspAssuWFGSWLssETGLVLSLEDAGtGRMKARFGTuPEhMDlsutNEApSuhTTlRRDG-hIcLsRtsENL+LuM+RlKGE	........PAKPVRAQANPGWFGSWLNPETGLVLSLEDAGGGRMKARFGTGPEIMDISGENEAQSSMTTLRRDGDMIHLARKDENLHLAMHRLKGE........	0	1	3	6
+7762	PF07931	CPT		Chloramphenicol phosphotransferase-like protein	Fenech M	anon	Pfam-B_29509 (release 14.0)	Domain	The members of this family are all similar to chloramphenicol  3-O phosphotransferase (CPT, Swiss:Q56148) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group  to the C-3 hydroxyl group of Cm, CPT inactivates this potentially  lethal metabolite [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.08	0.71	-4.64	7	191	2012-10-05 12:31:09	2004-09-17 17:09:32	7	3	165	6	65	615	54	167.20	29	83.68	CHANGED	uclIlLNGsSSuGKSolucslQslhssPWhphusDsah-t.h.schps...............sssGlcats.h...........tP.hchhhtuhhculsAhAcsGsslIlD....-lhhstch.h.-th.clLtshcVhhVGV+Csht.lhctREhtRGD.....RhsG.............huthQhchVHpss.YDlElDTotpsshECAttItpphp	.......................................................................plIlLNGsSSuGKoolA.psl.Q.s...h.h.s...p....s..a....h..p..l.ul...D...h...ahtt...h.s...s.pt.h.p...................ts..tGlp...h..hs......................ssh.hphh.htu..h..h.........cu..l..tu..h..hcsGhs..V..lsD......cV...hh..s..t....th....h.-th..c...hh..p.....u..h..p..V..h....hV..G...V...+..s.....s..-...ht..c..R..E.h..t...R...G..D...............R..h..sG...............h..st..t.p..t..c.h...s....H......t..s.s.....t..YD......h......c.l.DTot.....hssp-sAcpltpt..................................................................................................................	0	15	47	56
+7763	PF07932	DAP_C		D-aminopeptidase, domain C	Fenech M	anon	Pfam-B_29283 (release 14.0)	Domain	D-aminopeptidase (Swiss:Q9ZBA9) is a dimeric enzyme with each monomer being composed of three domains. Domain C is organised to form a beta barrel made up of eight antiparallel beta strands. It is connected to domain B by a short linker sequence, and interacts extensively with the domain A, the catalytic domain. The gamma loop of domain C forms part of the wall of the catalytic pocket; domain C is in fact thought to confer substrate and inhibitor specificity to the enzyme [1].	21.10	21.10	21.70	102.50	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.17	0.72	-3.86	5	78	2009-09-11 05:52:52	2004-09-17 17:10:48	7	3	77	1	15	36	1	96.80	72	18.63	CHANGED	c+sDIAGRY+ucELEA-hplsucGGulYGuFEGaLGpGPhEhM+slGcDVWhLuspRuMDAPAPG-WTLVFpRc-sGcVTGVTlGCWLAR+VsYsKs	...A.RQDIAGRYRSDELE.ADLLLVS...EGGAIYGAFEGFLGKSDMYPLYAAGPDVWLLPVQRSMDAPSPGEWKLVFHRDAAGRITGVTVGCWLARGVEYKR.L	0	2	8	13
+7764	PF07933	DUF1681		Protein of unknown function (DUF1681)	Fenech M	anon	Pfam-B_4989 (release 14.0)	Family	This family is composed of sequences derived from a  number of hypothetical eukaryotic proteins of unknown  function.	28.90	28.90	29.10	29.00	28.40	28.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.14	0.71	-4.67	23	357	2009-01-15 18:05:59	2004-09-17 17:14:00	9	8	219	1	230	343	4	159.60	47	61.76	CHANGED	saEplLhl.pscValY+IP..PpsSs+.GY+AuDW.sh-........p.hWTGRlRll.........................................scucps..pIpLEDssoG-LFA..........................psPhsphs..suVEsVhDSSRYFVlRlpss.sG....+pAalGlGFpDRu-AFDFNVALQDahKh.............scppsphspppp.................sppP..chDhuLKEGpTIpINlus	.....................hEplLhl.ps-VaVY.+IP..PR.so.s+.GY..RAu-W.pls..........p.hWoGRLRls.......................................................u..+..Gc....t..s....hI...+.........LED.p.....so........G...ELFA..........................p..s...Pl...cph......shuVEsVsDSSRYFVlRlpDs..s....G....R.+AFIGlGFs-Ru.DAFDFNVALQDHhKa...............................................lcpppph.tcptp......................................t.pttPplDhuhKEGpTIplsls.s.........................................	0	83	126	176
+7765	PF07934	OGG_N		8-oxoguanine DNA glycosylase, N-terminal domain	Fenech M	anon	Pfam-B_29151 (release 14.0)	Family	The presence of 8-oxoguanine residues in DNA can give rise  to G-C to T-A transversion mutations. This enzyme is found  in archaeal, bacterial and eukaryotic species, and is  specifically responsible for the process which leads to the  removal of 8-oxoguanine residues. It has DNA glycosylase  activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18)  [1]. The region featured in this family is the N-terminal  domain, which is organised into a single copy of a TBP-like  fold. The domain contributes residues to the 8-oxoguanine binding pocket [2].	20.10	20.10	20.10	20.30	19.50	18.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.67	0.71	-4.13	95	767	2012-10-02 11:58:57	2004-09-17 17:15:28	7	13	710	31	324	723	56	113.40	26	34.56	CHANGED	tl.hsttp..hsLptsL..psGQsF+..Wc.......cp.pss.........ahsll........t.s.....cllpl+.p....ps.....................splhhphht.............................................................pcshpphlpcYFsLch..s................Lssla.pph.....spt........Ds..........hhp.........................pthpph..pGlRl.L+QDPaEsL	.............................................................tp....hplp.sh....tsGQsFR...Wp........................pt...pst...................t....ahslh....................t.s....................pllp.lp..p....ss...............................................sp..lhhpsht.......................................................................................................tpshtphlpcYFsLsh..c.......................Lsplh.pph..........spt........Ds................hhp......................................ps..h..p..th....tGlRl.LpQDsaEsL........................................................................................................	1	121	203	278
+7766	PF07935	SSV1_ORF_D-335		ORF D-335-like protein	Fenech M	anon	Pfam-B_4933 (release 14.0)	Family	The sequences featured in this family are similar to  a probable integrase (Swiss:P20214) expressed by the SSV1 virus of the archaebacterium Sulfolobus shibatae. This protein may be necessary for the integration of the virus into the host genome by a process of site-specific  recombination [1].	21.60	21.60	22.50	21.70	21.20	18.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.71	0.72	-4.24	13	65	2009-01-15 18:05:59	2004-09-17 17:16:16	6	2	27	0	16	65	0	67.10	42	47.79	CHANGED	+tY...paGDhhIRERKG+YYVYKLEp..NGcVKEpYVGPLsDVVEoYlKlK...GGltssP.shshs......GhEPGooss	.......phaphuchhlREhKG+YYVYhlEp.psGch+-pYVGPLscVVEpYlchh.....uGl..ss..sP....ps.s........shpPss...h......................................	0	7	7	16
+7767	PF07936	Defensin_4	BDS_I_II;	Potassium-channel blocking toxin	Fenech M	anon	Pfam-B_56105 (release 14.0)	Domain	This family features the antihypertensive and antiviral proteins BDS-I (Swiss:P11494) and BDS-II (Swiss:P59084) expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N-terminus [1]. Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure [2]. Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism [1].	20.60	20.60	23.10	43.00	18.10	16.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-7.95	0.72	-4.28	10	17	2012-10-01 20:50:19	2004-09-20 09:42:44	7	1	6	4	0	17	0	34.20	50	68.19	CHANGED	ssCpCuuKp..GsYWhs.husCPuG+GYTGsCtYhlG	ssChCGsph..GlYWas.hssCPuGaGYTGpCsaahG	0	0	0	0
+7768	PF07937	DUF1686		Protein of unknown function (DUF1686)	Fenech M	anon	Pfam-B_5313 (release 14.0)	Family	The members of this family are all hypothetical proteins of unknown function expressed by the eukaryotic parasite Encephalitozoon cuniculi GB-M1. The region in question is approximately 250 amino acids long.	25.00	25.00	37.70	36.90	21.30	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.44	0.71	-4.66	8	27	2009-09-11 08:48:26	2004-09-20 09:49:39	6	2	2	0	23	27	0	149.30	37	33.28	CHANGED	osstluWNTuLYSLAVAGsIsYQlWlLApp...hRccGsusMlRpsWoAlGCMsPMhsuL......hHuGlIRSusYSlTVAG.......luAVhlYVQsuspc..GMsh+QhCslsuGNllLuuAChuGssKh.hsuststsphlssGlVsFuulLLLVshsccutsGcKspu..pG..ltshlhVhohhVsshsS........hVCGRD	......tsthsWNTulYSlAVsGsIhaQhWlLstt....h.ptGh.thhpptWsslushsPMhsul.......psGhhpSshYuhshsG.......huhshhhsQshhpp..GMshpphCshssGN..llLushChuts.t.....s.thshhlshGhlVhsulLlll.hh..tttGccs.s......pG....h.phlhlhohhVsshsS........hVsuRs..........	0	23	23	23
+7769	PF07938	Fungal_lectin		Fungal fucose-specific lectin	Fenech M	anon	Pfam-B_48600 (release 14.0)	Domain	Lectins are involved in many recognition events at the molecular or cellular level. These fungal lectins, such as Aleuria aurantia lectin (AAL,  Swiss:P18891), specifically recognise fucosylated  glycans. AAL is a dimeric protein, with each monomer  being organised into a six-bladed beta-propeller fold and a small antiparallel two-stranded beta-sheet. The beta-propeller fold is important in fucose recognition; five binding pockets are found between the propeller blades. The small beta-sheet, on the other hand, is involved in the dimerisation process [1]. 	20.80	20.80	21.20	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.04	0.70	-5.14	3	66	2009-01-15 18:05:59	2004-09-20 09:51:25	7	5	46	25	47	63	1	208.30	21	64.82	CHANGED	AQEVLFRTGIAAVN....SsN+LRVYFQDlaGSIRESLY..EuuWANGTupNVIGKAKLGSPLAAT...SKELpNIRVYslscDNlLoEssYDG.sSGW.lsGuLuusslsVuPsS+luulahuGoso..PplRIYtQKSssusuTIpEYhWsGssWcsGoshGVolPGTGIGsTsaRYTDYsGPS.IRIWFQTDDLKLVQRAYDP+oGWY.pLsTIFDKAPPRsAIAATSFssGpSSIYMRIYFVNSDNTIWQV....CWDHGpGYHDsRTITPVIQGSEIAIISWGsh..pGPDL+LYFQNGTYVSAVS..EWsWspuHGSQLG+pALPPA	.....................................................s.............................p..........t.h.............t...........h.....................u...t.............oslAsh...............t..........la.h.t...tt.....htphh...t....ttW...Gt...h.t.....th...s..Stlssh...s..............hlhh.....s.......h...t........................t.....W......t.............h......s.......sss.huh..........sh..........p..s..s......p...lRlaa.pss..shpl..hptsa..-...sp.p...W......s.s.h..h.s.p.s.......s.t.ssluAs..sa....t..ss..hclahhstt..s.hhph.........hhpt.t..........................................................................................................................................	0	10	29	40
+7770	PF07939	DUF1685		Protein of unknown function (DUF1685)	Fenech M	anon	Pfam-B_5502 (release 14.0)	Family	The members of this family are hypothetical eukaryotic proteins of unknown function. The region in question is approximately 100 amino acid residues long.	20.30	20.30	20.80	20.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.25	0.72	-4.33	14	160	2009-01-15 18:05:59	2004-09-20 09:54:41	6	4	21	0	97	154	0	61.50	41	29.40	CHANGED	LTD-DL-ELKGCh-LGFGF..-E..t.s........scLCsTLPAL-LYaulspph.st.....ptSsssssssssuo	......lTD-DL-ELKGClDLGFGF...sc..p..s.............scLssTLPAL-Lhauhspph.s......................s.s...................................	0	14	60	76
+7771	PF07940	Hepar_II_III		Heparinase II/III-like protein	Fenech M	anon	Pfam-B_5577 (release 14.0)	Family	This family features sequences that are similar to  a region of the Flavobacterium heparinum proteins heparinase II (Swiss:Q46080) and heparinase III (Swiss:Q59289). The former is known to degrade heparin and heparan sulphate, whereas the latter predominantly degrades heparan sulphate. Both are secreted into the periplasmic space upon induction with heparin [1].	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.90	0.71	-4.34	158	1644	2009-01-15 18:05:59	2004-09-20 10:00:19	8	23	1018	12	395	1466	1366	143.20	18	21.37	CHANGED	psGathlps......sps.hllhc...sus.ss........ssHuHuDsLuF-lts.suptlllssGss...........tt............sch+ph.hR.uTsuHsTlsls.spsps..phht...................thhh.....................ththpt.........t.....shhhsst+suYht..........................hshtHpRplh.ls.........sptlhs.D.................pl	...........................sGhh.hhcs..........psh.hl.h.h..c...sGsh.s.......................ssHuHsDphuFp..lhh.pGp..lhhDsGths...........Ytp..................tphpth..h+..sotuHNTlh...ls....sps.pp..thst.......................shth...................................t.......................ttth.......thhh.s...s..hps.u.Ys.............................s.h.h.a.pRplh.ls......tphhhlhDp..............................................................................................................	0	167	309	348
+7772	PF07941	K_channel_TID		Potassium channel Kv1.4 tandem inactivation domain	Fenech M	anon	Pfam-B_7603 (release 14.0)	Family	This family features the tandem inactivation domain found at the N-terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N-terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to being about fast inactivation of the Kv1.4 channel, which is important for the channel's role in short-term plasticity [1].	25.00	25.00	38.40	36.70	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.91	0.72	-3.75	2	44	2009-01-15 18:05:59	2004-09-20 10:06:49	6	2	32	2	20	45	0	72.40	77	11.62	CHANGED	MEVAMVSA-SSGCssHhPYGYA.QARARERER.AHSRAAAAAAsu.......GpGGs.GGGsthpt....ppts.ppp-	MEVAMVSAESSGCNSHMPYGYAAQARARERER....L....A.....HSRAAAAAAVAAATA.AVEGuGGu..GGG..u..HHHH...QoRGAsoSH-...............................	0	1	1	8
+7773	PF07942	N2227		N2227-like protein	Fenech M	anon	Pfam-B_5433 (release 14.0)	Family	This family features sequences that are similar to a region of hypothetical yeast gene product N2227 (Swiss:P53934). This is thought to be expressed during meiosis and may be involved in the defence response to stressful conditions [1].	20.10	20.10	20.10	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.79	0.70	-5.44	12	457	2012-10-10 17:06:42	2004-09-20 10:09:33	7	12	292	0	334	464	12	246.30	33	63.30	CHANGED	ss..hhsshhchsKlpssl+plsRDWSsEuptER-tsapPllppLsphhP.t.h-pppsplLVPGuGLGRLsa-luph..GatspGNEFSYaMLlsSpFlLNhspppspaplYPalHsaSNphspsDQLRslphPDhpshs.hs.......s.sshShsAGDFl-lYsps.......................psaDsVlTs..FFIDTAcNll-YlcTItplLKsGG..lWlNlGPLLYHFp................sh...ssphS.......lELoh--lhtlhpp.hGFpl.pccp.I.....cssYs..sN.cSMhpshYtssaass++ss	................................................tt.....s...chsKlpssl+phsRDWSs..-G..t.t...ERcss.apPllpp..........lp....phh..s............................t.....p............t................p...ph..p.....lLVPGuGLGRLsaEluth..........Ga.......t.s.p......GN.................EhSaaM..LlsSpal.L...N..t.........s.......p.............t................p.....papla..Pal.p.p.hS.Nphpp.psp.l+sl.thPDlpP.ts......hs.............................sshShsAGDFhp...l.Y.sp.p...................................................................ttaD...s..lsTs..FFIDT.Ap.NllcYlcsIhph...L..+.....s..........GG...........hWlNl..GPLLaHat................................................................s..........s.........................lELo.h--lhtlhpp.hGFph....t........pp...t...h......................ssYh....ts.pShhp....hYps.hassp+.t..............................................................................................................	0	128	204	285
+7774	PF07943	PBP5_C		Penicillin-binding protein 5, C-terminal domain	Fenech M	anon	Pfam-B_1086 (release 14.0)	Domain	Penicillin-binding protein 5 expressed by E. coli (Swiss:P04287) functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (Pfam:PF00768) is the catalytic domain.  The C-terminal domain featured in this family is organised into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides [1].	21.20	21.20	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.85	0.72	-3.97	74	4610	2009-01-15 18:05:59	2004-09-20 10:14:53	8	6	2602	30	731	2984	1285	93.00	27	23.36	CHANGED	F-shplhppsp.l...tphpVhtGpcc.....pltlsstcDl...hlsl.s.....+sptcplpsphph..ppslp......APlp+GphlGpl......ph.hhsschltp............h.sLlstpsVcc	..............................................Fcshphhptupth....sstpVh.h.G.cpc........plsl.s.s...pcsh...hlsl.P.......+..u..p..h...p.p...l......+.s.p.hsl.....pppLp...................APlp+GpsVGpl........ph..phc.s..c..p..ltp....................h.sLlshpsVtc.........................	1	223	436	575
+7775	PF07944	DUF1680		Putative glycosyl hydrolase of unknown function (DUF1680)	Fenech M	anon	Pfam-B_4918 (release 14.0)	Family	The members of this family are sequences derived from hypothetical bacterial and eukaryotic proteins of unknown function. One members of this family is annotated as a possible arabinosidase, but no references were found to back this. These proteins are related to a large family of glycosyl hydrolases.	24.90	24.90	24.90	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	520	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.74	0.70	-6.23	20	1388	2012-10-03 02:33:51	2004-09-20 10:18:10	7	35	764	0	436	1283	178	495.00	25	73.60	CHANGED	sV+lps.uhatpptcsspphll.....ltsD+........lhcshh............hpuhlsstt........shGsaE.........................h.uhshpssslG.....+aLpulAhhhAspsDspLcp+hcplls.tlucsQp.......sDGYLsuhhptt...........................shscsWss............hYsht+lhtGhlshYphoGppphLclsp+hADah....hsshus-phpchhhs...pHsthp..ulscLY..............phTG-p+YLcLA+hFhcpcshsP...................................hshspDclsshctsTtlu+sV.......GhAclaphoGDsshhp.......sucphWpslss++hYlsGGsusp....................EtFssshclsspssh...sETCuolshlhhsc+hhphs........s-.upYsDhhE+sLYNslLuuhs.Du..stahYhsPL...tsssp+.p..........hppcapuhhCCsssshcshsphucalYsps......cc..slaVNLahsSpschchpu...lpLcQcTs..aPapuplplTl.........psstssphsLtLRlPuW.................uuu...splplNGcs........sspttssuYlplsRcWpcGDplpLpLPMslchhtu....p-ssspVAlhpGPlVhs	.................................................................................................................................................................................................................lpl.t.s.shht.p.h.phshphhl......h..cp............h.ts...........................ps.......l...s.h..t..........s.h.s.....p.....................................s.h.h.p.spshs.......+alcuhu.h.h.s..t.....p.....s.........D.........s.............p.......L....c....p....p....h....c....phlp....hl.ttsQp..............sDG..Ylsshhphp............................................................s..p.ppWss..........................hYsht+hhp......u..h....lsha...p......h..T....G......p....p....p...........h....Ls....lsp+h.AD....al..............................ss.......h....us.t.p.....h....p.....h....h..h....hs................t+.s...t..........hp......u.....lhc....LY.....................ph..T...s..c.......t.......+.......Y.LpLA....p....hFhc.pp.sh.ps...........................................................................................................................................hthpps.c.lsh..h...c.t.p.....s...t.lu..+sV.......................Gh...uc...lh..ph.....o...s........D.....p..t.....hhp................sspphWp.s.hsp.+.chY.lTGGhuup.............................................EtF...s..s..s......h.p....l.s.sp..hsh..............sE.o.Cu..slshhh.hs...........cchhphp........s..-...upYADhhE+............sLYNsllu.u....h.............s..............-s..............t...ta.......hY..h...sPL...........pstspp....................................hppta...h.u.....h.s.CCss..Nhscshsph.s.p.h..l..Ys...p.................................ss......sla..lsl.Y.h.s.sp..hp....h.ph.......t......s..........l..p..lppp.os............YP...a...p...t.....p.......l.plsl............................p.s.s.p.s.s.p..a.sLtlRlPsW.....................spt....sp...lp.l.......N...Gpt.....................htts.hts.u..Ylpl.p.R.p..W.p.pG.D.p..l.plp.lP.M.t...l+hh..hs.......ps.tsplAlt+GPlVhs.................................................................	0	156	320	388
+7776	PF07945	Toxin_16		Janus-atracotoxin	Fenech M	anon	Pfam-B_50381 (release 14.0)	Domain	This family includes three peptides secreted by the  spider Hadronyche versuta (Swiss:P82226, Swiss:P82227, Swiss:P82228). These are insect-selective, excitatory neurotoxins that may function by antagonising muscle  acetylcholine receptors, or acetylcholine receptor  subtypes present in other invertebrate neurons [1]. Janus atracotoxin-Hv1c (J-ACTX-Hv1c, Swiss:P82228) is organised into a disulphide-rich globular core (residues 3-19) and a beta-hairpin (residues 20-34). There are  4 disulphide bridges, one of which is a vicinal disulphide bridge; this is known to be unimportant in the maintenance  of structure but critical for insecticidal activity [1].	25.00	25.00	84.30	84.20	19.90	16.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.25	0.72	-4.28	2	4	2012-10-01 22:06:18	2004-09-20 10:20:42	6	1	2	1	0	4	0	35.80	87	97.95	CHANGED	sICTGADRPCAACCPCCPGTSCpu.EsNGVSYCRpD	..sICTGADRPCAACCPCCPGTSCpGPEsNGVSYCRND.	0	0	0	0
+7777	PF07946	DUF1682		Protein of unknown function (DUF1682)	Fenech M	anon	Pfam-B_4955 (release 14.0)	Family	The members of this family are all hypothetical eukaryotic proteins of unknown function. One  member (Swiss:Q920S6) is described as being an adipocyte-specific protein, but no evidence of this was found.	23.80	23.80	23.80	25.00	21.50	23.70	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.96	0.70	-5.58	39	327	2009-01-15 18:05:59	2004-09-20 10:21:26	9	6	273	0	236	331	0	316.70	27	76.34	CHANGED	hpsahhEhh.slshlllhlhhahh..GpppNcphAppa...hpsppshhppp..FuhlGhstst...............................hlhccu.spashYATGRpssstlhlslcLhpRpshhshl.hphlhsh............pDphplpl.............................spsshDs............hlaAlVpKpshpph+c-ph.-L................Sh......spop-ptpLPpphslhoEusElsstlls.sp...........lhpsls.ps.sch...lcaltlTDQshtps.p.p.............cts...................................c+plhlshslPpsss.....ht..phttLlshhlphhDpls........shclps-shcKscpsRppthcchhKttcpt+tEt..htpc+tctK+pc+cphhsphosEcQ+Kh-.........cKcpc+pt++	.........................psahh.Ehh.hlshllhhhh.ahh..GpppNpphAptW...................hps..p....ps...lLppp..FuhVG.ssstp.........................................pshLhccstp.ash..asoGRpsspshhlplc..........hhpRpsh.lshl.hchhhsh............pDplplpl............................t.hspps.hDs..............aVaA..lspKcshpphp..c-...hh.DL.....................Sh.............spstsp.....t...LPsp....hslhSE..sElss.s..hls..sc............hhpslp..ph...uch..............lchlthoDQ.ss......p.....psp............................................s++plhhs.hs..lPssss..................hp.shhsLhphhhh.hhDplt.............ph+hs..t-s..hpKs..cpsRpch.cphhKhpctt+tEt..t.tpc+ccp++tc+-chhpp.ss-cQ++h-.........c+cpc+p.++.........	0	83	130	194
+7778	PF07947	YhhN		YhhN-like protein	Fenech M	anon	Pfam-B_5325 (release 14.0)	Family	The members of this family are similar to the hypothetical protein yhhN expressed by E. coli (Swiss:P37616). Many of the members  of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues.	25.00	25.00	25.60	25.00	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.43	0.71	-4.92	119	1531	2009-01-15 18:05:59	2004-09-20 10:23:20	9	5	1341	0	371	954	58	182.60	31	82.28	CHANGED	h.hphlhKshshlhLhhhsht......................sshshhl.hsuLhhShlGDhhLh...................pphFlhGlsuFhlAHlsYlhs.Fh.............thhtshphhhshshhshus...................shhhh...lhspl..............st..hphsVssYshllssMsht.Aht....................hhtshsthhsslGAllFllSDsll...AhscFh.......hshshsphhl.hsoYasAQhLI.shuh	..................................................phlhKslsllLLhlhshp.......................ts.hsshshhl..lsGLsh.ShlGDsLhh.............................................hsppphhhuluuFhLuHLhYshhFs...................tphshs..h...hh..s.ls.ls..l...h.ll.us...............................................................l.hhsl.......lhscL...............................tc...hphPVss.ahshlhsMshh..Asthh.............................................hhtsss.suh.shhGA.hLahlSshl.l.hhs+ap....................pphpts.s.hll...husYauuphLIstS.................	0	101	189	287
+7779	PF07948	Nairovirus_M		Nairovirus M polyprotein-like	Fenech M	anon	Pfam-B_5426 (release 14.0)	Family	The sequences in this family are similar to the Dugbe virus M polyprotein precursor (Swiss:Q02004), which includes glycoproteins G1 and G2. Both are  thought to be inserted in the membrane of the Golgi complex of the infected host cell, and G1 is known to have a role in infection of vertebrate hosts [1].	22.00	22.00	22.90	35.40	20.60	21.90	hmmbuild  -o /dev/null HMM SEED	645	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.36	0.70	-13.20	0.70	-6.40	6	90	2009-01-15 18:05:59	2004-09-20 11:34:11	6	2	7	1	0	87	0	473.40	69	41.74	CHANGED	PTNRSKRs.pscIILThsQGLKKYYoKILKLLcLT.EEDoEGLLEWCsRhLupsCDDsaFpcRIpEFFl..TGcGaFNEVL.FK..S.o.usThsPs+su.....usss-PF+SaaAKGhlphDSGYFSAKCYs+ASNSGhQLINlTpHshKlssTPGPKhoNLKolNCINLKsSsDK-HsElEINVLlPQVAVNLSNC+Vll+SHVCDYSLDsDGsI+LPplp.HpG....oFIPGTYKIlIDKKNKtNDRCsLhTNCVIKGRElRKGQSsLRQY+TEI+lGpspuGoRRLLS.Esuss-ClSRTQLI+TEoAElHsDcYGGPG-KITICNGSTlVDQRLGSELGCYTINRIKSaKLCENSAouKuCEIDSsPVpC+QGaCLKIoQEGRGHVKLSRGSEIlLDsCDoSCEIMIPKGoGDILVDCSGGQQHFLpsNLlDLGCPNlPLLGKMAIYICRMSNHPKTTMAFLFWFSFGYVITCIhCKllFYlLIllGTLuK+lKQYRELKPQTCslCEssPVNAIDAEMHDLNCSYNICPYCASRLTSEGLsRHVsQCPKRKEKlEETELYLNLERIPWhVR+LLQVSESTGlALKRSSWllVLLlLLsVSlSPVQS....APlupu+sVpsYpsREsYsuICLFIhGSVLhAlShLh+GLlDSlG	..................................hhph.h.t+lLphhths.-.ss-tL.pWCpc.ht.sCssshhppRIpEFFh..supuhFN-VLph+h.s.s.tso..ss..st......sss.shhp.hu+t.Lph.SshhpspChsts.ssu.Qhls...Hss+lhpTsGPKhpsl+slpClNlcsph.K-pp.l.lsVLhsplsVsLpsC+s.Ipu+.C.YshshDG.l+lPphh.+pG........hhh.GsYpIslDhpsp.NcpCpLhTsCVlKG+El+KGQS.L+tYpTEl+lsps.sGpR+LLu.ctsss-ChStTQLh+TEssElHsDsYGGPG-KITICNGSTlVDQRLGSELGCYTINRV+oaKLCENSAosKsCEIDShPVKC+QGaCL+ITQEGRGHVKLSRGSEVVLDsCDoSCElMIPKGTGDILVDCSGGQQHFLcDNLIDLGCPpIPLLGKMAIYICRMSNHP+TTMAFLFWFSFGYVITCIhCKslFY.LIllGTLGK+hKQYRELKPQTCTICETsPVNAIDAEMHDLNCSYNICPYCASRLTSDGLuRHVsQCPKRKEKlEETELYLNhpRlPhhlRpLLplS.usGhsLKRusWhhsLLlLhhlolSPVQu....APlGcGKTIEsYpsREsaTSICLFlLGSlLFlVShLhKGLVDSlu............	0	0	0	0
+7780	PF07949	YbbR		YbbR-like protein	Fenech M	anon	Pfam-B_4990 (release 14.0)	Family	The members of this family are are all hypothetical bacterial proteins of unknown function, and are  similar to the YbbR protein expressed by Bacillus  subtilis (Swiss:O34659, Swiss:O87088). One member (Swiss:Q97EN2) is annotated as an uncharacterized secreted protein, whereas another member (Swiss:P43521) is described as a hypothetical protein in the 5'region  of the def gene of Thermus thermophilus, which encodes  a deformylase [1], but no further information was found  in either case. This region is found repeated up to four times in many members of this family.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.74	0.72	-3.86	190	4025	2009-01-15 18:05:59	2004-09-20 11:52:03	7	7	1621	2	591	2564	94	83.70	18	58.23	CHANGED	lPV........psphspsh..lsshps....pssp.VplpGsp.shl......sslpphps...ps....Dlsslsp......sh.shp.....lsl..hssssssph...........Psplp..Vpl	.............................l........h.st.....s.ssh..tl..t.sh.ts..........pstp..V.plsG.sp..shl..........................ppl..p.p.h.ps.....ps.......Dl.ss.lst...................sh.shp..........lpl.......ss.st.ssph..............Ps.plp..lpl...................................................................	0	239	414	504
+7781	PF07950	DUF1691		Protein of unknown function (DUF1691)	Wood V, Bateman A	anon	Wood V	Family	This family of fungal proteins is uncharacterised. Each protein contains two copies of this region.	21.70	21.70	22.00	21.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.47	0.72	-4.14	38	223	2012-10-03 07:11:12	2004-10-06 09:55:10	6	5	115	0	163	218	1	114.70	21	62.00	CHANGED	sshluhHhhsspllPlls..sssuupssLthlptlhtpts...........hthhlLlsssshHlsuGhshhhthp..........................ptpp++pthhhl........................sshstlG.....hulhhhu.thp.h.t.s.............ssa	....sahuhHhhsspllPlhs.....s....ssu.....opssLthlcphhtp.s...........hthhhLlsssshHlsuGlshhhhhp.................................pppt++htthhh...................................t.s.hs.....hshhhhh.h.t.................ht.hhh.........................................................	0	25	72	131
+7782	PF07951	Toxin_R_bind_C		Clostridium neurotoxin, C-terminal receptor binding	Finn RD	anon	Pfam-B_3087 (release 15.0)	Domain	The Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1].  This domains is the C-terminal receptor binding domain, which adopts a modified beta-trefoil fold with a six stranded beta-barrel and a beta-hairpin triplet capping the domain [1]. The first step in the intoxication process is a binding event between this domains and the pre-synaptic nerve ending [1].	25.00	25.00	50.90	50.90	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.82	0.70	-4.64	10	143	2012-10-02 19:42:32	2004-10-06 11:27:06	7	3	31	75	3	169	0	187.30	42	17.41	CHANGED	YsspssoslLKDFWGNsLpYDKEYYllNlsp.N+Yl.....shp..oc.l...h.htt.p....ph.NhahNtppLYpGhKlIIK+hu...ssssDshVRpsDhlYlNh.shsNpcYp.Lhhps......spst.tpcll.hhclussssshsphhlhphp.hsshssY.Co.lFpsss..sNslGL..lGh+p.....s.....p..hsslVASsWYhsplccp.pp..sGCaWpFIPp-cGWsE	..Ypsps.sshLKDFWGN.LhYsKcYYhlNhhp.NpYIshp..psuh...h.....Rs...ps.shalN.p.LYpGhKhII++hu...pussDslVRcsDhlYlsh.hspspEap.l...h......tpsp.tEKll.hhpIsssstths.hhshp.p..ss.ssh.Cph.Fppsp..sspIGL..lGhHp...........p..hshhltSpWYhpplccps.s..hGC.WpFIsc-cGWtE.....	0	1	3	3
+7783	PF07952	Toxin_trans		Clostridium neurotoxin, Translocation domain	Finn RD	anon	Pfam-B_4943 (release 15.0)	Domain	The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. Subsequent to cell surface binding and receptor mediated endocytosis of the neurotoxin, an acid induced conformational change in the neurotoxin translocation domain is believed to allow the domain to penetrate the endosome and from a  pore, thereby facilitating the passage of the catalytic domain across the membrane into the cytosol [1]. The structure of the translocation reveals a pair of helices that are 105 Angstroms long and is structurally distinct from  other pore forming toxins [1].	25.00	25.00	27.40	26.10	20.00	18.80	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.97	0.70	-5.53	8	149	2009-01-15 18:05:59	2004-10-06 11:34:15	7	5	32	46	7	144	0	292.30	51	25.87	CHANGED	slFaYLaAQKhPcshpsIoLTsSl--ALLsssKVYTFFSS-aIspVNKsVpAuLFlsWlppVlsDFToEuoQKSTlDKIADISlIVPYIG.ALNIGNEstKGNFcsAhElsGAuILLEFlPELhIPllusFoIcSals..pNKNKIIKTIsNALccRpcKWcElYuaIVosWLo+lNTQFsphKEQMYpALpNQssAIKpII-YcYNpYot-EKspIss-aNIpsIcscLNcKlshAMpNIs+FlsEsSlSYLM.Khh..htlcKLp-FDsslKstLLsYIhcNpthLs.splscLpshVNsoLssoIPF....cLSpYTsDpILIphF	...............shFaYLcAQchsps.psIsLTSSh-cALLppsK..lYTFFSo.....-..aIcsl..NK..sVpA.uLFlu....WlpQll.DFTpEssppoThDKIADISlIVPYIG.ALNIGNpstKGNF...pp...AhplhGuuILLEFhPE..lhIPsltsFhl..Sal...pNKsclIcsIsNALpcRscKW.....c.....-hYthIVupWLoplNTQF.pl+EtMYpALp.QspAlKpIIchcYN.Yotc.....E....Ksplp..pash.slps.....cLNppls.AMpNIscFls-sSlSYLMKphhPhtlp+Lp-aDpslKp.LLsYI.cpp.hLh.spspcL.pshVsppLpssIPF....pLSpYTssplLlphF................................................................................................................	0	1	6	6
+7784	PF07953	Toxin_R_bind_N		Clostridium neurotoxin, N-terminal receptor binding	Finn RD	anon	Pfam-B_1058 (release 15.0)	Domain	The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. This domains is the N-terminal receptor binding domain,which is  comprised of two seven-stranded beta-sheets sandwiched together to form a jelly role motif [1]. The role of this domain in receptor binding appears to be indirect.	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.45	0.71	-4.81	13	203	2012-10-02 19:29:29	2004-10-06 11:35:29	7	7	33	77	5	232	29	185.80	43	15.67	CHANGED	sNhlhDhSGhsoplphssDltLs..lNsssltLpsssp...sVshsNslhhNuhhsNFSIsFWlRhsphssp........chslIssh.csN....sGWcI.lcsNsllaolhDsNGpp+slah........SDhl.NpWaaITIosDRLpsp.hIaINspLlsscsIcslhNIauSNsIsh.....lscNp.IaIcthsIhsKpL	.................................................pNtlhDhS..GYsoplphscsl.tLss...lspN.phtLpus..sp...p.lpls..sNsIlaNuhapsFSlSFWlRIsphpsp........cYTII.ssh..cNN.....SG..W.cIsl...p...s...s...t...llaoLh.DssGppcslh...Fp.t...thSDYI..N+WaFlTITssRLssp...hIYINGpLlsspsIcpl.t.sIauSspIhhthst........s...hsp...sphlaIchFsIFs+pL........................	1	2	5	5
+7785	PF07954	DUF1689		Protein of unknown function (DUF1689) 	Groocock L, Finn RD	anon	Groocock L	Family	Family of fungal proteins with unknown function. A member of this family has been found to localise in the  mitochondria [1].	25.00	25.00	35.60	51.40	24.90	20.30	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.87	0.71	-4.35	13	52	2009-01-15 18:05:59	2004-10-06 11:36:28	6	2	43	0	33	49	0	161.10	33	56.82	CHANGED	acsulcFYEtDppL-spDRhpLucshpoluhushhuGasuhsuuFhsPhsYhta....pstul+GlssP+.............oFllGlsuhhlusphsu+htas+plpphcs.........................................sspp+phcsh+hhchspsuhashYYhpTupsPphpl.DP+phhpp......LKcs	...acsAlcFYEtDphL-scDRLcLucshpoIuhuphhuGahuhhusFhsPhhYpha....pstul+GVpls+...............sFlLGlhshhhusphsu+hhYs+plsphcss........................................spsp+Qhshh+hh-.s..ssutashYahhThpsPph+l.DP+shhpp.....h+...........	0	5	17	31
+7786	PF07955	DUF1687		Protein of unknown function (DUF1687) 	Groocock L, Finn RD	anon	Groocock L	Family	This is a putative redox protein which is predicted to have a thioredoxin fold containing a single active cysteine [1].	20.90	20.90	21.10	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.91	0.71	-4.18	9	121	2012-10-03 14:45:55	2004-10-06 11:38:47	6	4	117	1	95	114	0	139.10	28	85.85	CHANGED	MShF+TLQ.pP.csIoLFspsttst..upclhphLcpshssp.............Fcl-l.sschPThDQLphhts.h.ps..........pshltsphP....................................chpplhcphscs...tp...pshtsshap.....tPLhVDW-pshlus-......hpslcchL	................................................................a+.h.pp....csITLFHpsstss..Sp+lhslL+ps.suss.ttsss.........................pF-.L.-l...spc.PThDQL+hIl-ahsts.h............sshlpssh...........................................p.pcsl+thpps......................t..s..tFp.....cPlsVDWsNG.p..hust...............................	0	18	51	80
+7787	PF07956	DUF1690		Protein of Unknown function (DUF1690) 	Groocock L, Finn RD	anon	Groocock L	Family	Family of uncharacterised fungal proteins.	28.40	28.40	28.50	28.60	27.90	28.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.69	0.71	-4.21	7	160	2009-01-15 18:05:59	2004-10-06 11:42:59	6	3	127	0	118	152	0	114.40	28	78.45	CHANGED	VasPpoPlsFSpsLluQL-sSsEoDaoRpQhsE+alpc+VupcLppLE.EslKcFcspLpsShhss.cs.psspsslSostlspclcsLpp+Lp...pLpptchpK......t.cchpss.....RuclscCLhcNcsKPLNCa-El-tFKchsh	...................................s.hthStshlppLp...s...s...........EoD...s..Rtp.hEh.lpt+lu...tcLpc...l...pt...p...p.......t...p...h...p...p...h..h.....pt.......t........................t.....tttt.p....tl...........SptplppclptLp.t+Lp....t.plpphp.t..............ppu.......+ptllpCLptNpt..+PLsCacEV-tFKp.V.t.......................	0	25	58	97
+7788	PF07957	DUF3294	Ribosomal_MRP8; 	Protein of unknown function (DUF3294)	Groocock L, Finn RD	anon	Groocock L	Family	This family was annotated as mitochondrial Ribosomal protein MRP8, based on the presumed similarity of the S.cerevisiae protein to an E.coli mitochondrial ribosomal protein; however, this similarity is spurious, and the function is not known [Wood, V].	20.00	20.00	20.00	21.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.44	0.70	-4.81	10	45	2009-01-15 18:05:59	2004-10-06 11:45:09	6	1	44	0	30	36	0	208.10	43	98.55	CHANGED	MS...-.....lEpL+KcVscLpslV+KQutLIuKTGcpVl-LQlsppKschsshs.......sppspp..suplDsoDaATNEDLVQLVsELQGQLDsLE-RSIRRhsNSp..tp--c-llAPIPNtDG-hPs.p.......DthhPcTLcEFccl.-clcLh+Lu+FYEllPPs.p-pEchcchLcs..psEshch........sttsDc-lpcclcchoc-ElD-l..Fc-lARYLGLRsRRGossW	...................MSsc....lE.LpcpVs-LpsLVKKQShlIoKTGppVLELQlccpKpclsshs.......sppsss..ssphDsoDaATNE...DLVQLVsELQG....QLshlEERSIRRllNSp...ppcD-D.llAPLPNsDG-lPs.........-slFPpTLcEF+cl.sclcLl+Lu+FYEhlPPs.pEpEch-.phL-s....psEshpl........spss-c-IpcclcpaSc-plD-h..Fs-lARYLGlphRRGophW..................	3	7	17	27
+7789	PF07958	DUF1688		Protein of unknown function (DUF1688)	Wood V, Finn RD	anon	Wood V	Family	A family of uncharacterised proteins.	25.00	25.00	49.70	29.80	22.60	21.90	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.48	0.70	-5.94	32	232	2009-01-15 18:05:59	2004-10-06 11:46:41	6	3	181	0	163	231	29	398.00	45	92.28	CHANGED	shLpohpAVR-Rupplh...phAcpschpHFslc.s+hsssAsaVsslI+ccYss....pIP.HuRWpHF-sGG....lsRhspLhsphs.....................-s.EpuRthlDLhlVSVLLDAGAGspW+YpEstssph....auRSEGLAVAShchFhsGhFSu.DsscPhpVDupuLppLohppLupuFQVoss.NPLsGLEGRspLLp+LGcuLtspsplF.....Gsp...uRPGsLlDaL.............tsssss.lshsplhssLhssLsPIWP.uRsplcGh...sLGDsW.pssl.......................sss.ssullPFHKLoQWLsYSLlpPhpp..hGlplssh-hLTGLPEYRNGGLhlDhGVLsL+cssht....................h.sassscshIVEWRALTVuLLDcLtshVpppLs..hssppLsLAplLEuGTWpAGRclAtppRPp.usPPItIhSDGTVF	.............................................................aL+SlpAVR-Rsphlh...phA..p.pscLsHFslc..s+hsssAsaVsslI++cYsss......sIPsHuRWpHF-sGG.......hsRlspLhpphs...................t.hDshEcsRphlDLhlVSVLLDAGAGspWpYc.-s.t..oGph.............apRSEGLAVASLcMFpsGhFSu....-s.s.....p.Ph.pVDutuLpplosptLupGhQlots.NPlsGl-GRssLLpRLGcuL...sps-hF.........Gtp............uRPGsh..lDaL...........................ttsussshlshsslWssLhs...sLsPIWP....uR....splsGh..................slGDsW.pssl................................................sst.hpsllPFHKLoQWLsYSLhtPhpc..hslphssh-hLTGLPEYRNGGLhlDhGlLsLKstsht....................hshapss--lIVEWRAlTVulLDcLtshVpppLs..hssppLsLAplLEuGoW+.................uGRclAttpRP....s.......ttPPIhIhSDGTVF......................	0	46	87	133
+7790	PF07959	Fucokinase		L-fucokinase	Adamkewicz J, Finn RD	anon	Pfam-B_121298 (release 15.0)	Family	In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by L-fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalysed by GDP-L-fucose pyrophosphorylase [1].	27.50	27.50	27.50	28.90	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.37	0.70	-5.91	6	272	2009-01-15 18:05:59	2004-10-06 11:47:43	7	11	161	0	110	250	6	326.70	26	42.43	CHANGED	uGG.S+RlP.AsshGKlFTsLPh...-pspt....Lss...plLsLp.shhpcF.spu..Gl..hlsouD...lhsss-s.hlshsc.susssluhPsoLslAosHGVaVscppss.tc.shphpllcchLpKPTlE-lhphpAlp+sGphhh......DoGll.hcscss..-sLhthshpsuphhlsah-L.lsshp.EhshYtDhltAhuPu...Ea......sphsocsht.t..hh.hRp+haphhpt.slshl.lssupFhHhGTop.EhLp+hous.ssl....tlsp+phss.Pshpsps.ttossIloShlsuslSlussSl.lppS+LusslpIGupCIVoGl.lhppsuh.u..........L.DhlC..hcVhhsGslphVhhhhGlpDNhKsSl+p....cuhpFhGhsappsLcchsIcsoDlhsSss..pshsLWsA+lFPVhoshc	........................................................uGG.SpRhP.hsshGKhhoslPh............tpsp..h.......l.p....phhpL..shh.ch..tthss.G.l..hlssuD........lh.hs.....t....p...h........p.....h.........sp....s.....shh..s..huh.s.s.shupsHGVal.sp.........p.......s..............................lp.hLpKsohpch...t.sl...........ts.t..h.h....................s.Ghhh.h..sschs.........-.Lhth.p.h...ps.s...h.p......hs.....hh........t..........h....................t.h.....sha.Dhhhshu.........c....................sp.t.pt.h...........................p..t..s..lshh.....l......ss.....upahahsTo....t...E..hlpphht.....th.........................th..ttp.h.........s......................hl.suhl.pst...h..ph.ssssl..lp.spl.ts..s...hpluptslloGh...p.......th................................shhh....p..lh.................s......p.....t...hshh.hGhpDshctt.......tt.tahshsh.phh.t..hslp......-hh..ts.....sL.sAplFPlhp...p.............................................................................	0	40	59	81
+7791	PF07960	CBP4		CBP4	Groocock L, Finn RD	anon	Groocock L	Family	The CBP4 in S. cerevisiae is essential for the expression and activity  of ubiquinol-cytochrome c reductase [1,2].  This family appears to be  fungal specific.	20.60	20.60	21.60	23.10	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.77	0.71	-4.52	18	129	2009-09-10 15:02:01	2004-10-06 11:49:54	6	2	125	0	95	123	0	115.40	33	85.79	CHANGED	p+ssWhhWsKhhhsGusIhsuGshLhpYhoPTDE-Llp+asPEL+pch.cpRchRQpE.p-hhphlKcpSKSDcPIWpsushcS...E.+c..............p+pctt..pt.php+tppEhcchcpppppp+c-	........t....hhhWhKhhss.GuslhsuGshLhpassPT-E-Lhp+asPELp+c..cpR..ctRQpE...pchhpplK-hS...cSD......cPIWtsst.ps...Ecp...pt.pt................ht+.ptcp...p+pphtchtt...............t..............	0	19	49	80
+7792	PF07961	MBA1		MBA1-like protein	Groocock L, Finn RD	anon	Groocock L	Family	Mba1 is an inner membrane protein that is part of the mitochondrial protein export machinery [1][2].  It binds to the large subunit of mitochondrial ribosomes and cooperates with the C-terminal ribosome-binding domain of Oxa1, which is a central component of the insertion machinery of the inner membrane. In the absence of both Mba1 and the C-terminus of Oxa1, mitochondrial translation products fail to be properly inserted into the inner membrane and serve as substrates of the matrix chaperone Hsp70 [3].  It is proposed that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosome exit site to the insertion machinery of the inner membrane [3].	27.40	27.40	27.40	27.40	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.27	0.70	-5.52	7	74	2012-10-03 02:27:23	2004-10-06 11:51:34	6	1	72	0	48	79	0	223.40	28	77.91	CHANGED	ppsppc.pshs.+alGlhs-halPsua..h.sshssPhhhhphLhRRhYhhulNThpluhFRhpoGhKPpFh.WKNcAIEsYlpVNcuFAp+sL...........pplcshsolWVpcALptRu+plPsssch-WpLlKFssVPKLluhpsh.lPspshE.hlQllY+FcT+Q+Ll+hs+tssKs-phD+sVl-YlualpDuoTs..-hlLhGSVFESs.scshLPcss.sssplslppM+ssGDIaR.ssu	.................................................................................hs.p.lG.lhschalPsth...hss.htp.s.h..hhphl.hR+hhhhshN.......ohplh...ha.+..h...p.........u..h.....+.....p.Fh.WKspAIEhalpsNpuFAptsl.................splcthsu....hhl.cuLtsRs...p.....phP.t..s.s.pLsWpLlKasps...P........KlVS..h...psh.l........s..s...t.s...h.p....hlQlVh+hsT+Q.....+l.l...p............hs....ptp...p..........p......s...pph....-....+..Dls-YlVa.....h..s.shss....-hhlhGplFESp..psh..s...p........stp.h.t.....tuDlaR....t.......................................	0	11	26	43
+7793	PF07962	Swi3		Replication Fork Protection Component Swi3	Wood V, Finn RD	anon	Pfam-B_9217 (release 15.0)	Family	Replication fork pausing is required to initiate a recombination events.  More specifically, Swi1 is required for recombination near the mat1 locus.  Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilises stalled replication forks [1]. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling [1,2]	25.00	25.00	25.20	25.30	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.76	0.72	-4.35	29	279	2009-01-15 18:05:59	2004-10-06 11:52:44	7	7	238	0	196	269	2	84.40	34	27.13	CHANGED	KLcsp+LhSp.+GlPtLc+t....................h.cch+hpu+s+E......................hs-LspllphYQhWsHcLFPKupFcDhlshlEpLG+p.+plpshhpchhpcth.	........................................................KLstpRLlup.cGlPtLp+h.............................h..cph..K..h+.G.K.GHE................................hpD..LppLlphYphW.sccLaP+hpFcDhlshlEpLGpp.+plp.shhpchh.c..s................................	0	58	101	157
+7794	PF07963	N_methyl		Prokaryotic N-terminal methylation motif	Bateman A	anon	Pfam-B_6484 (release 14.0)	Motif	This short motif directs methylation of the conserved phenylalanine residue.  It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596.	21.20	20.50	21.20	20.50	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.24	0.73	-6.49	0.73	-3.90	72	4741	2012-10-03 10:38:27	2004-10-06 12:39:50	7	22	2129	0	985	9899	3456	19.90	44	11.31	CHANGED	pGFTLlElllslsllullhs	...+GFTLlElllVlsIlulLs...........	0	364	650	834
+7795	PF07964	Red1		Rec10 / Red1	Wood V, Finn RD	anon	Wood V	Family	Rec10 / Red1 is involved in meiotic recombination and chromosome  segregation during homologous chromosome formation.  This protein  localises to the synaptonemal complex in S. cerevisiae and the analogous structures (linear elements) in S. pombe [1]. This family is currently only found in fungi.	25.00	25.00	41.40	41.40	24.40	22.60	hmmbuild  -o /dev/null HMM SEED	706	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.24	0.70	-6.37	6	28	2009-01-15 18:05:59	2004-10-06 13:14:18	6	2	24	0	18	30	0	598.10	30	82.59	CHANGED	hllLclhapssph+plItpLlc...scashplG.LlDN.IpDhQLsNallElLSpsFs++usspstlsphPpL.WpcppKsK.FFppphYPapuKaGsttlhpFlhsp..FushlsNhs+l+plhashust..pspsltsLsppscpt.hahQsIasplYhWsGEssFlclc+.KslcIh+-L+splcl....Klhs.sFccslpospcthht...........TlppsptFpl-Fp-pphschahps.sNlPKISEVQsalsLpa.pp.--p.I-spspc-pso+cpsl.ppcptssss-u............hphutpcspa-p....TP-+s...htpcssl.DL........ppssccpc...cshss.Klp.ppsph.psph.pllppp....pSPlsphQc+KltRssSKoh.........c.L+psh-cpt....lpsppspScpshspshpsssslsspsplpss........tutcltsphsucp.pssssVsshochpssKohKppDlsl....L-sIFupPlsKtp+p...K.p+pKQ.hLpNhhshh..........KoKh.ltsNsppsh+optlpptcosphss..ph..........sppusP.s.tch.tcQssoosshtpss+sshcs+sPptpppKlEshststphssh.........sKpNsts.sp.ss.cpth..tpp.t.sshp.......................shu-STTIss.sup..s........FTspLQ-QIapSIspFSsELppKIuIINpEhNpKIl+ELSEKYpplF+-LppsFpsDspcMhpFVGElK-MhpLPE-pLVptIRs+pF	......................................................s.hl.plh.phs.p.+phIhpllc...scastplGplhDs.lpDhQ.sNaLlElLSsCF.+psssphtl.phPpL.W.ppcp.Ks.c.FFpsp.YPapuKpGp.pshpFlhpp..Fhspl.s.hshl+plsYssup...p.pslchh...p.tpsc..p..halQsIasplYlWhsE......p..........t.lEhc+.KplcIsK.sLKsplpI....+ltp.shppslpostsphhh...........hhs+s+tFQL-FpDpphs-pFapshsNlPKISEVQsFLsLsah-p.s........-sphp..c-pp.tpss..tpppptpps.sp.................hp.uhspspt-...lhTP-cS...sph+oDtWDl........pssopppp...sshss.Kls.pp.pphppp..p..pl.pc-......................QSPlV.sQhRKhtRpoo+TL.........EhL+p-Fpppt..................lpsppspspp..s..htp..sshlhtpsphhps...................ppp.p.s.pshthschpsspSlpK+DIsl.........LsTIFupPssKtp+p.........K.ppppQppLpNaK.Pllpl..............spsc..lps.ss.tps+shclpphposphsp...............tp.spsttttch.ppp....s.sposs.pthspsscctphsc.stt+.p.tptptphsh.....................sppssts.sp.ss.pp....ths.sps.pssslo.......................shh.-STTlls..hps...s......................ssFTspLQEQIasSIspFSNELh+KIsIINpELNpKIl+ELSEKYQpLFt-LQpsFQsDspcMhpFhGEIK-hhpLPE-pLVphIRs+KF................................................................................	0	2	8	17
+7796	PF07965	Integrin_B_tail		Integrin beta tail domain	Bateman A	anon	Pfam-B_1876 (release 14.0)	Domain	This is the beta tail domain of the Integrin protein.  Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.	20.10	20.10	20.30	20.10	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.32	0.72	-10.88	0.72	-3.55	58	524	2009-01-15 18:05:59	2004-10-06 13:37:43	7	25	119	21	230	460	0	83.70	32	9.93	CHANGED	C.spp+cCVpCptFpsG.h..pc....sCstpCpph.l..phVcphppps...........Cph+Dp-.-ChhhFshp...psss...sphhlhVhcch.-CPpuPs	...........................Csp++sCVpCptFspGph....pp.....sCsptC.pth.l...phVcph.....pcpspss...........tCph+Dp-.D...ChhtFsat........tsss......scshlpVlcc......-CPpuPs.........	0	30	46	122
+7797	PF07966	A1_Propeptide		A1 Propeptide 	Rawlings ND, Finn RD	anon	Pfam-B_386 (release 15.0)	Motif	Most eukaryotic endopeptidases (Merops Family A1) are synthesised with signal and propeptides.  The animal pepsin-like endopeptidase propeptides form a distinct family of propeptides, which contain a conserved motif approximately 30 residues long. In pepsinogen A, the first 11 residues of the mature pepsin sequence are displaced by residues of the propeptide.  The propeptide contains two helices that block the active site cleft, in particular the conserved Asp11 residue, in pepsin, hydrogen bonds to a conserved Arg residues in the propeptide.  This hydrogen bond stabilises the propeptide conformation and is probably responsible for triggering the conversion of pepsinogen to pepsin under acidic conditions [1,2].	20.50	20.50	20.70	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.93	0.73	-7.15	0.73	-4.01	85	802	2009-01-15 18:05:59	2004-10-07 15:04:45	7	5	152	8	295	720	0	28.40	36	7.79	CHANGED	ll+lPLcKh+SlRcsLpEpGhhpcaLcpp	.....lh+lPL+KhKSlRcsLpEc...GhhpcaLcp........	1	23	33	100
+7798	PF07967	zf-C3HC		C3HC zinc finger-like 	Wood V, Finn RD	anon	Wood V	Domain	This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in  nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling  events [1]. The domain is often repeated, with the second domain usually containing  a large insert (approximately 90 residues) after the first three  cysteine residues. The Schizosaccharomyces pombe the protein containing this domain  (Swiss:O94506) is involved in mRNA export from the nucleus [2].	20.80	20.80	20.80	20.90	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.15	0.71	-4.40	28	278	2012-10-01 20:49:39	2004-10-07 15:12:26	8	8	216	0	192	304	7	127.90	26	24.50	CHANGED	Phs+tsahpRLcTFpshs.W..........ssKPstloslpsA+pGWhs..hs......p-tlpCp.sCpspLshp..........................sphstphhcphsccatttlp.suHcpsCsW+spsss.cthtths..lsts.pshlsshtc.....chssLhph.....spLPhhss	..............................hs+pshhpRlpTF.....p...t...hs...W..........tsKPp.tlsslthA+pGWhs.....ss............t-hl...cCs..sCp..stLshp....................................sthshp...hhpph...s...pch.tp.tls.s......uHpp.C.Wt....spsss.cphhhls.....hsps..thhlpthhp+hppLhph..........t.............................................................................................................................	0	55	103	156
+7799	PF07968	Leukocidin		Leukocidin/Hemolysin toxin family	Bateman A	anon	SCOP	Domain	\N	20.40	20.40	22.20	21.40	17.00	16.10	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.59	0.70	-4.74	19	1628	2009-09-11 18:55:27	2004-10-27 16:53:05	7	6	341	102	22	554	5	237.50	36	70.82	CHANGED	pslQFsFlcDtpaDKcslllphsG.pIsSshphsssps......phspthhWs..........tpYslul..ssssssspllc..hhP.KNp.cphpVppThGYslG..Gsl..pl.psGPs....huusuoasaScoIsYsQpsY+oplsppssp.slsWsVctsphsssstt...........shasp.lFhhscppss..supp.FlspschPsLspuGFNPpalsllopcpssspoo.chclsYpRshD.hhshh.tp......hhstpsac..shps+phss...pYcVDWcs	................................................QslpFsFlcDppYsKcsLllKhpG...IsSthph.s.cs.........hsthhWP.................tpYsl..ul...p..sssssssllc..YhP.KNp.-otpVpp.TlGYshG....Gsh.......psu.o......hG.hsuuhsaScTIo..YsQpsYcTpl-.ppssc....sVtWsVcApphhsssht.........pssasp.LFhts+ssuh...tupp.FlspsphPsLlpSGFNPpFlsslS....+-..+..s.s.s..cpS.chcloYp.RshDhhphthspp............hhs.spsap..shhscphos....pY.EVDWcs...........................................	0	10	12	18
+7800	PF07969	Amidohydro_3		Amidohydrolase family	Bateman A	anon	Pfam-B_751 (release 15.0)	Family	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.16	0.70	-5.26	43	5270	2012-10-03 00:45:34	2004-10-27 17:18:53	6	49	2463	42	1791	12984	4622	377.00	18	74.72	CHANGED	hlhPGFlDsHhHlhstshth..hhshtssh..shtthhthht......................hshsaspsthtptchs.sttsl..-tsts.stshhhtch.tphshlspt..uLph......................t.t.stshltppst....hhht................th.s.hsshtphtphhct.thtthsptGlssshsss..............s.tphhpshtplsppht.hsh.hhh.h......................................sshphhssGs.s..spsuhhtp..hsssh....phth....sttp..h.pplsptspppththplau.............ststulsphlsshcphhtp....................hhh+sphssspshcthtplshthshts........h...........hh.phhss.phphs....hshtthhssG.....hplshuoDhsh...sshsPh.hshtssshtpsht...t.hhh....................................pplsltculphhTtssAhh....hshpcph.GpltsGt.ADlsl	.............................................................................................................................................................................................................................................................................................lhPGhlD..sHhH......h...t.h..t.h..t......h...........................t........h....s.h...t.ssh..............s....h...t..h.t.................................................................h...s........t........h.......s.....t......t......p...h.................s.....h.tpl............c.t...ht.................s....hh....h.......t......................h.hspt......ulph.........................................................................t..tps...p..s...h.l...tpps..........thhht.......................hh.s................s......p..p.....h.t..t.....h...lp......t....hht.h.sp...h..Glsuh...sst.........................................................t......h...p....h..h..h....p...h...........s....t...p......s.............................................................................................................................s.u..h....h...h........s...t.t..........shs..u.h...h........t......................h.........s...p....p.........................................................................p.......s.................h..........s.pp...................l..pph..h...th...s.....t.....p..t..u..h...t.h.t...l.au...................................................................t.s...t.u.h.p...p..h...l.s...s...h....pph.hhp................................................................................hlt+.s...p...h....h....t........t...s.......h..t.......t..h....t....p....L....t...h..t...h..s..h.ts............................................................................................h.................c...t...p...t.h..................h....h.....t....p....h....h....p..t.G..................................h.tl.s.h....u...s..D....sh..............sshsP..h....hs..l....t....s....u..s....h.t....p..s.h...p............t.....h...h........................................................................................................................................................................ptl.s..l..p..p..A..l..p.hh..T.t.suAht............ht.hp.......c.t.......GslpsGp.ADhll.................................................................................................................................................................................	0	578	1162	1523
+7801	PF07970	COPIIcoated_ERV	DUF1692; Erv41; Erv46; 	Endoplasmic reticulum vesicle transporter 	Mistry J, Wood V	anon	Pfam-B_2028 (release 16.0)	Family	This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi [3].	21.90	21.90	22.00	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.89	0.70	-4.73	51	979	2009-01-15 18:05:59	2004-10-28 13:59:39	7	20	303	0	653	899	28	187.70	29	53.30	CHANGED	CYGAt..............stptCCNTC--VppAYtp+tWshsssp.slcQCpp-....h....ptphs..EGCpltGshpls+lsGshHhAPGp...shp.tthH.h...HDhp.hpp.........phNhoHhIpcLsFG......pp.....hs.t.............pP...LDshph.......t.pp.pt...hhapYalKlVPTpap............cospaSsspap+slpsst.............tuhPGlFFpY-hSPlplh.ppp+..pohtpFlsslsullGGlasluullD	...................................................................................................................................t.....-G..CplhG..lpVNKV.sG.s.FHhs.stp..............sh.................th.t...................................ht..htt.....................phNhoHhIpc...LSFG....pt........hsshh..........................sPLDssph..................tp.p.t............................hhapY..alclVPThY.phttt............................h.popQaSVT.p....pp...cshptt.................................tslPG.laFpY-lSPhhVh..hpEp+...psahpFlsplCuIlGGhhsluuhl......................................	0	250	385	541
+7802	PF07971	Glyco_hydro_92		Glycosyl hydrolase family 92	Mistry J	anon	Pfam-B_1199 (release 16.0)	Domain	Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation [1].	24.50	24.50	24.80	24.60	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.66	0.70	-5.86	187	2270	2012-10-02 14:50:22	2004-10-29 16:03:55	7	44	847	40	652	2109	326	474.50	31	62.78	CHANGED	u.pph...t.uhlpF...st.....spp.......l...s+lulSalS...h-pApt...NLct....Eh..........s..shs..F-pl..pppApstWscp.Lu+l.pV..p..........u.....ss....psp.....pphFYouLY+shltPphhs-........h.....sup..................Yp.u.....t...........................t.............uht........Yss.a................ulWDTaRuhaPLhsllpPp.hss-hlpShlsha.c..ps..........GaLPcWthsspp.stsMsGspussllADAa...hK..G............lp.shD......hc.pAacAh..h+sAp.............ps....................+sG...........lppah.phGYl..P...........................hsc...u.......sSpTLEYAYsDasluphAc.u...L...........Gcpp...............................-.h.ptahcRupsa+Nlacsp.......................................sGFhps+......p..ts..........G....s......at..........t......s.......asP..h.............th...s.......psah.EGsuW....pYoahV.PHDhsGLl.pLhGGc..................ct...........Fhp+LDphFst....ht......................hGpY....s.hGNEPuaHhsYLYsas.GpPa+TQphlRplhsphYs..sss..sGls.G..N-DsGpMSAWYlaSu.lGhYPlsPG...sstYhluoPhFccssl...pL.........................sG.......+...s.hsI....pA.pssu........tc.s.........hYlpusplNGcshs....+..sa..lsHsc...lh..pGGpLpapMuspP	...............................................s...tshhpF...t.st...spp.......l.ph+luhSalS...h-p.....Apt.....NLpt.Eh..........s...shs...F-..ph..pp...pupstWpph.Lu+.l.pl...p...................s................ss....psp.............pphFYosLY+shlhPphht.-.h.......ssp..........................Yp..sh...pt...................................pht..s.t...h.....Yos..h......uhWDTaRshaPLhs.Ll..P.c.t.h.pchlpuhlsha.c..ps.................G..a.L.P...cW....hs.....sp..........c.s................shM..........sGstussl...lADAahK.....G.............lp...shD.......hp...puapAh.....hcsAp..........t.............................s+tu...........h.t.t.Yh...chGYlP.........................sphpc........u..........lScTLEYAasDasluphAc.tL...........Gc.pp...............................p.t.pha.hpR.ut.s.Y.+.s.l.acsp.......................................s.Gahps+pss.................................Gs............at..................................s............s..........FsPh..................ph....s........psas.Eu...suWpYoa...........hV.......HDhtGLl.pLh..GGc..................c.s............Fhp+LDphFst....h.t.....................h.h.Gpa..s.huNpPuaHhsYLYsa..s.G..pP.....h+TQthl+p.....l....................h...................p...................p....h...................ap.................sss.........sGh...s..G..............s-DsGpMSAWYlaou.lGhYPls..PG....pspYslGsP.hFc.c.spl..pL........................t.sG....+p..hsIps..tsss..........tc..s.................hYlpphplNGc...........h..s.........p.sa..ls.H.pc....lh....pGu...pLpaphusp............................	0	232	458	572
+7803	PF07972	Flavodoxin_NdrI		NrdI Flavodoxin like 	Finn RD	anon	Pfam-B_1603 (release 16.0)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.55	0.71	-4.21	86	2192	2012-10-03 05:08:30	2004-11-12 15:12:44	6	3	1921	11	257	1337	42	121.30	41	86.07	CHANGED	lhasS.hoGNT+RFl.....c+Lsh...t.+hshp........thsp......hplscPalLlsPTYusGt...tsu........VPppVhcFLs..cNcphlpGV..........luSGNpNFGsp.ashAuchlup+hpVPhLhcFELtGTppDlpplpp	...................................lha.S.hSsNTcRFl.......p+Lsh.............u...c.hslp............ttpp.........hplcEP...al.Ll.l..P.TYGsGss....tsu...............VPctV.hcF...Ls.......t...p.N.....+....p...h...l.....+G....V..........luSGNR.NF.G.pt..ashAuch....Iup...+h..sV..Ph..L..h..+FELh.G.TppDlcpV+..........................................	0	54	135	202
+7804	PF07973	tRNA_SAD		Threonyl and Alanyl tRNA synthetase second additional domain	Finn, RD	anon	Pfam-B_270 (release 16.0)	Domain	The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain).  The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.06	0.72	-4.07	219	11375	2009-01-15 18:05:59	2004-11-15 16:21:20	9	40	4904	28	3159	8949	4659	48.10	36	6.80	CHANGED	lRll.....ph.G...s................hsh......-LCuGsHlpsTucI..ttF+lh.......ptsshspslpRIh	...............................lplh.....ph.G...-.................................h.....-LCtGs..HV.ssTucI...th.FKlh........................ptsuhsttlpRI...........................................	0	1065	1968	2631
+7805	PF07974	EGF_2		EGF-like domain	Bateman A	anon	Pfam-B_80 (Release 16.0)	Domain	This family contains EGF domains found in a variety of extracellular proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.44	0.72	-3.78	51	1990	2012-10-03 09:47:55	2004-11-17 13:40:45	8	364	173	0	1055	1784	147	30.20	42	4.71	CHANGED	C....s......Css...pGpCs........tthCpCpsu.....atGspC	...............C.t.............Csu....+GpCs...........sGpChCpsG.......apGssC....	0	399	519	772
+7806	PF07975	C1_4		TFIIH C1-like domain	Finn RD	anon	Pfam-B_10678 (release 16.0)	Domain	The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif.  The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (Pfam:PF00130) [1].	24.60	24.60	24.60	25.20	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.47	0.72	-3.96	16	268	2012-10-02 13:15:50	2004-11-17 14:18:53	7	7	237	1	201	260	6	52.60	46	12.05	CHANGED	hCauCQpph.s...p................phYpCspCcphFClDCDlFIHEoLHsCPGCps	..........................................CauCptphss..............................................ptYpCstCpphFClDCDlFlHEsLHsCPGCt....	0	62	106	161
+7807	PF07976	Phe_hydrox_dim		Phenol hydroxylase, C-terminal dimerisation domain 	Finn RD	anon	Pfam-B_19435 (release 16.0)	Family	Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product.  The enzyme is comprised of three domains.  The first two domains from the active site.  The third domain, this domain, is involved in forming the dimerisation interface.  The domain adopts a thioredoxin-like fold [1]. 	20.90	20.90	21.40	21.60	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.99	0.71	-4.65	78	504	2009-01-15 18:05:59	2004-11-18 16:03:01	7	14	183	10	351	544	44	164.70	24	25.89	CHANGED	FsuGhulcYssS.hLs..........spss.p.................................pt........LAsslhlGpRhhoupVlRhuDupshcLtctlpuDGRaRlhlFuGchpt.s..p..sh....s.plpplsphLs.sssShlp+assts.....................tphs.Sl.l-lhslapss+psl-lt.DlPp.lhpPhptphth...........Dap+lass.D.t..........pscsachh..G.lDccc.G	..................................................FsoGhulcYssu.hls.......tpss..p.................................pt......lussltsGpRh.ssp..VhRhuDupshcLpc......pl.us..Gp.aRlhlFu.Gs.pt.sp...h..........ttlpshs...phLt.t.p...Shlppassts..........................tt.s..Sh.h-lhh.l.......a.......st...+pp.l-lp.s.lPt.hhp.s......h...........sh.c.lass.-..............tsphaphh..G.ls.p..............................................................................	0	72	165	283
+7808	PF07977	FabA		FabA-like domain	Bateman A	anon	Bateman A	Domain	This enzyme domain has a HotDog fold.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.75	0.71	-4.69	51	6557	2012-10-02 20:54:35	2004-11-19 13:29:09	8	37	3882	226	1494	3917	3933	124.30	34	64.08	CHANGED	LPpch.hLhlDRlhpls.sGtp.....lhu.Kslo.s-.FFpsHF.scPVMPGsLhlEAhhQhsGhhhhht..tpspG.........h...ulscs+F+tpVhPss.plphclchp+......p+hs.huhucuhshVDGchlhpAc	....................................LPHRhPhLhlDRlh-hp.....t..........u.pp.......................lhAhKsVoh..N.....E.....F...F....p....G....H....F.Ps.p...Pl.....MPGVLllE.............AhAQ....s....s....G....lh.......hh.....tp...................t.tp.G......................thhhh..hGlcc.s+F+p..V.lP.G..D...pl..h.hclchh+........p+ts..hsh.hcuhu.h..V.DGc.llspA...............................................................	0	441	905	1223
+7809	PF07978	NIPSNAP		NIPSNAP 	Mistry J	anon	Pfam-B_3436 (release 16.0)	Domain	Members of this family include many hypothetical proteins.  It also  includes members of the NIPSNAP family which have putative roles in  vesicular transport [1].  This domain is often found in duplicate.  	22.30	22.30	22.30	22.30	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.04	0.72	-4.04	42	1376	2012-10-02 00:20:33	2004-11-23 10:06:50	8	10	733	16	670	1283	354	97.80	20	66.90	CHANGED	aE..lRsYplcPuphsta.hptatcthhthht.htschlGhahs...............phGs.hsplhtlasasshssRpthRsthhpDstW.ttthptstth..lpp.csplhhPsshSs	....................................E.htpYplc.P.s..p..h..t..p..a....hp...t....a.tc....t..h...h......h....h...p...t....h...s....s..chlGhah.s...............phGs...hspshtla...sap.s.....hpshcp....hRpt.hh.p....c....s....ta....tt..h....h...t..h..s.h..t....h....l.pp....csphhhsh................................................	0	183	323	489
+7810	PF07979	Intimin_C		Intimin C-type lectin domain	Bateman A	anon	Pfam-B_1879 (Release 16.0)	Domain	This domain is found at the C-terminus of intimin. Its structure has been solved and shown to have a C-lectin type of structure [1]. Intimin is a bacterial adhesion molecule involved in intimate attachment of enteropathogenic and enterohemorrhagic Escherichia coli to mammalian host cells. Intimin targets the translocated intimin receptor (Tir), which is exported by the bacteria and integrated into the host cell plasma membrane.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.59	0.72	-3.81	14	389	2012-10-02 16:37:33	2004-11-24 13:34:50	6	10	133	15	2	312	0	94.00	48	12.60	CHANGED	Pspl.IsVspps+ssYssApspCp..shuupLsSSpspLps......lYspWGAANKYpaYpupsoIoAWlpQTssDhpsGVuSTYDLVTpNsl.N......VsssssNAYAVCVK	.........Psph.ItV-ptp+ssYs-A.shC+..s.su.LPSSpshLus........lYssWGAANKYsaYpu.pSlTAWIpQTss-ppuGVoSTYDLlTpN.l.s......Vslss.NsaAVCVc...........................	0	0	0	1
+7811	PF07980	SusD	SusD_RagB;	SusD family	Mistry J, Bateman A	anon	Pfam-B_1855 (release 16.0)	Domain	This family includes several hypothetical proteins.  It also contains RagB, Swiss:Q9ZA59, a protein involved in signalling [1] and SusD, Swiss:Q8A1G2, an outer membrane protein involved in nutrient binding [2].	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.83	0.70	-4.87	151	6618	2012-10-11 20:01:00	2004-11-24 15:06:21	6	10	210	38	1597	6145	784	279.40	17	50.72	CHANGED	sEhIa......ththtt.ssssssshshthhhtstss............................tshsthts.........opphhsha............................................................................pspDsRhtt.shhh.tttht.....................................................................................htt.ststshsshhhpKahs.............................ttssstssstsh..........lhRhA-lhLhhAE...Ahh............chuss.......sp.....Ah..phlNp....l...R..pRA..................................................................uhsshs.s................................ssthhp...tlhp.ERthELshE.spR.ahDLhRh.................................................................................tthhpphtthttstpththtttt...........................................................................................lhPIPpsplsts............ssLp..Q.N...s........Ga	.....................................................................................................................................................................................................................................................................................................................................-.hh...................................................................................................................................sh.s...h.h.s.............s...p...h.h...p..a.................................................................................................................................t.s..p...D.....Rhth....s....hh.h....t..h..........................................................................................................................................................................................................................................................t...t.....t...t....s..h....s..s.h..h.....h.t.Kahs...................................................ttsstt.t...ss...t.sh...............................lh...RhAElhLhhAE....Ahs...................................c.hsss........................sp..............Ah.....phl.....N.p......l..........R..p..Ru.............................................................................................................................................................s.h...ss...h.s..s....................................................psth.h.p........tlhp.ERphE.Lsh.E....G....t.....R.ahDL.hRh.................................................................................................................................ttth..t..t..h..t.t.h.h...t..t..h.....t.......t..h.t.h.....t...................................................................................................................................................................hhP..I.P.p....s.p.l.p.hs......................st.lh..........Q..N...sua............................................................................................................................................................................................	1	756	1474	1596
+7812	PF07981	Plasmod_MYXSPDY		Plasmodium repeat_MYXSPDY	Mistry J	anon	Pfam-B_3138 (release 16.0)	Repeat	This repeat is found in two hypothetical Plasmodium proteins.	21.10	21.10	41.10	21.60	15.70	18.60	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.69	0.72	-5.92	0.72	-4.22	24	71	2009-09-11 18:54:15	2004-11-24 15:52:40	6	2	1	0	71	71	0	17.00	79	98.85	CHANGED	MYhSPDYTL.hVtLPDT	MYFSPDYTLRLVQLPDT	0	71	71	71
+7813	PF07982	Herpes_UL74		Herpes UL74 glycoproteins 	Mistry J	anon	Pfam-B_3076 (release 16.0)	Family	Members of this family are viral glycoproteins that form part of an  envelope complex [1].	25.00	25.00	29.80	29.50	17.30	17.60	hmmbuild  --amino -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.54	0.70	-5.79	4	191	2009-09-11 13:31:48	2004-11-24 15:59:50	7	1	15	0	0	100	0	200.00	65	81.24	CHANGED	+VLSppGKpt.cKhK.-ILKpLhu.opDhY+FahhPopQ+lhNlslsMccFPpsYILAGPIpNcSITahWFDFYSTQLRKPAKYVYSEYNHTu+KITFRPPSCGTVPSMsCLSEMLNVS+RNsTGEcuCGNFTTFNPMFFNVPRWNTKLYVGSsKVNVDSQTIYFLGLsALLLRYAQRNCTRSFYLVNAMSRNLFRVPKYINGTKLKNTMRKLKRKQAPVKE.spKKSKKSQ.STTTPYSsYTTSTsFNVoTNVTYSsTssspRlsTSTIuYRPDSsFMKSIMTTQLRDLATWVYTTLRYRp-PFC+ssRNRTAVSEFMKNTHVLIRNETPYTIYGTLDMSSLYYNETMsVENETASDNNETTPTSPSTtFQRTFIDPLWDYLDSLLFLscIRNFSLQ.PsYGNLTPPEHRRAVNLSTL	..........................................pVLSphGK.cLcphKlEILKQL...ppDhYphahp.o+QtlpNlThs.MscFPph.Y.ILAGPIpNpSITYLWFDF..YSTQLRK..P.......A.........KYVYSpY.....NHT.A..+pIT.....FRP...PsCGTVPS...............................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+7814	PF07983	X8		X8 domain	Bateman A	anon	Pfam-B_374 (Release 16.0)	Domain	The X8 domain [2] domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen [1] as well as at the C-terminus of several families of glycosyl hydrolases [2]. This domain may be involved in carbohydrate binding. This domain is characteristic of GPI-anchored domains [4,5].	25.70	25.70	26.30	25.70	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.15	0.72	-3.49	189	1389	2009-01-15 18:05:59	2004-11-24 17:27:23	8	20	213	4	865	1350	0	72.40	35	18.91	CHANGED	hhCVs.p.sss.....sspphtshhsasCu......st..s.-CsuI.sssus..........Css......ps+hSashNpYYppp...sp.s.ssuCsFsGsAs	....................WCVsp....s.ss.....spspLpss....lsaACut.........t....uDCss.Ipsuus............Cap.....shts+uSYAhNsYYQpp......sp..s.....sssCsFsGsA.........	0	131	493	696
+7815	PF07984	DUF1693		Domain of unknown function (DUF1693) 	Mistry J	anon	Pfam-B_3630 (release 16.0)	Domain	This family contains many hypothetical proteins.  It also includes four nematode prion-like proteins. This domain has been identified as part of the nucleotidyltransferase superfamily [2].	19.80	19.80	19.90	19.80	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.07	0.70	-5.27	11	296	2012-10-02 22:47:23	2004-11-25 10:17:43	7	7	97	0	182	265	0	287.70	57	67.88	CHANGED	Lsa-QVpRLcslLsEslPIHGRGNFPTL-lp.+plV......................................................psVRu+LE-p......GlpV+DVRLNGSAASHVLspDsGluYKDLDLIFslsLss-ss.......FphlKDVVLssLLDFLPcGVsKEKloshTLKEAYVQKhVKV..ssDsDRWSLISLSNssG.KNVELKFVDSlRRQFEFSVDSFQIhLDSLLhFhcsupsshoEsFaPTVlGEShYGDFpEAhsHLpp+LIATRsPEEIRGGGLLKYCsLLVRsFRPuspp-lKsLERYMCSRFFIDFPDItEQpRKLEuYLpNHF..............hGt-.cs..................KY-YLMpL+cVVsESTVCLMGHERRQTLsLIohL	.......................Lsa-QVpRLcplLsEslPIHG....R....G....NFPTLplp.+pIV......................................................psVRs+Lpcp......GItV+D..VRLNGSAASHVLtp..-s.........G..hu.............YKDLDLIFsl..-..L...s..-tp............FphVK-s.VLssLLDFL....PcG.Vs+cK.......I...os......hTL.KEAYVQKhV.KV....s.sDs.......DRWSLISL...S..Nss...G...KNVELKFVDSlRRQFEFSVDSFQIhL..DSLLhFa......ps....u.....p.....s..Ph.o.-.....s.F....aP..TVl..GEShYGDFpE...AhpHLp.p+lIuTRpP...E...EIRGGGLLKYCpLLVRsF+Ps.s.pt.-............l.K.sLpRYMCSRFFIDFsDls-Q......p+KLEsYLpNHF..................sG.-..pp...........................+YpYLhhL+pVVsE..STVCLMGHERRQTLsLIshL.................................	0	45	59	114
+7816	PF07985	SRR1		SRR1	Wood V, Mistry J	anon	Pfam-B_29119 (release 16.0)	Domain	SRR1 proteins are signalling proteins involved in regulating the  circadian clock in Arabidopsis[1].	20.70	20.70	20.70	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.75	0.72	-4.04	38	284	2009-01-15 18:05:59	2004-11-25 16:25:20	7	8	229	0	197	286	1	58.00	31	18.80	CHANGED	cl.lClGLGshp.........pshsupaQLAhllhlhchh...pl.....splplY..DPlFsps-t...........phlp.slG	......phlChGLGshs................pshsupaQLAhl.lhlh-th.......ph.....................tps...la..DPlFoph-h...........phLppL...........	0	59	96	156
+7817	PF07986	TBCC		Tubulin binding cofactor C	Mistry J	anon	Pfam-B_4111 (release 16.0)	Domain	Members of this family are involved in the folding pathway of tubulins and form a beta helix structure [2].	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.65	0.71	-4.70	52	603	2012-10-02 17:34:32	2004-11-29 14:13:34	7	18	275	4	417	624	21	115.80	23	26.40	CHANGED	spshplpshppCplhl......hsshsslplcsspssplhh.GsVsuSlalcsCpsspllssspQlRh+sspssshalpsso.pPII......EsspslpFus....ashhYstlptphtts.tls..sss.Wsp..ltDF	.............................phhlpphppshlhl...................hsshss....lplcsspss.t.llh..G...............s...V...s...sulalcsCcssp..lh.....l.....u..C..p.....Q.............lRl............+ssps.splaLt......s..s..........o.....pP..II.......Ess....ps...l.pFuP............a.sh..hYstlptphtts....sls......sp..Wsp...................................................	0	171	246	344
+7818	PF07987	DUF1775	Bacterial_GLE1; 	Domain of unkown function (DUF1775)	Mistry J	anon	Pfam-B_12641 (release 16.0)	Domain	Domain found in bacteria with undetermined function. Its structure has been determined and is an immunoglobulin-like fold.	25.00	25.00	27.60	27.50	24.30	23.90	hmmbuild  --amino -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.91	0.71	-4.36	87	551	2009-01-15 18:05:59	2004-11-29 14:53:07	6	4	483	1	162	455	4	130.40	35	57.34	CHANGED	HVol...ps..spAssGuat.phsh+VPpts-st.uTsclcVplPps..ltuspspPtPGWslpspcsshttsh....tt.hspsVsplsWouss....lsss..pascFslps.plP...tsssslsFsshQshscG....ss.cWs-.sts....Gt.-s.cp...............PAPslpls	................................................................HVol...ps....spuss.Guat.phsh+VPsEps.s..uTTKlplplPpG..ltht.ps...pPh...sGWphchpKss................sttlp.plsWpuss.....l.ss..papcFshsu.p.P......pctsplsasshQpYpDG.......slVcWs.........Gptcs..cp................PAPhhpl.h.......................	0	42	102	139
+7819	PF07988	LMSTEN	Wos2;	LMSTEN motif	Wood V, Mistry J, Bateman A	anon	Pfam-B_4851 (release 16.0)	Motif	This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.	19.30	19.30	23.60	26.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.24	0.72	-4.67	6	191	2009-01-15 18:05:59	2004-11-29 16:03:41	7	19	45	2	59	174	0	46.60	72	7.43	CHANGED	csNhlphsQsusAhIQppasD.EDP-KEKRIKELELLLMSTENEl+pKp	..............clNIVNl.PQPuuAAIQRHYsD.EDPEKEKRIKELELLLMSTENEL+GQp..	0	3	7	23
+7820	PF07989	Microtub_assoc	Spindle_assoc; 	Microtubule associated	Mistry J, Wood V	anon	Pfam-B_45034 (release 16.0)	Domain	This presumed domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules [1]. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB) [2].	21.90	21.90	22.10	22.00	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.40	0.72	-4.15	15	383	2009-09-11 00:31:27	2004-11-29 16:39:38	6	11	174	0	233	391	5	72.10	39	5.41	CHANGED	TLRE.EpplscL+KENFsLKL+IaFLEEplp..pcss-sscclhKpNI-LKlEltoLc+-lpcpcchLpcAp+slcs	.................sh+-.-pp..lscLcKENFsLKLRIaFLEEphp..............pphc.sstcchh+cNlE.LKV-ltoLp+-lpchcchLpcsp+slc.s........................................	0	56	101	170
+7821	PF07990	NABP		Nucleic acid binding protein NABP	Wood V, Mistry J	anon	Pfam-B_10222 (release 16.0)	Domain	Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterised [1] and  contains two putative phosphorylation sites and a possible dimerisation  / leucine zipper domain.	21.60	21.60	21.80	22.40	19.60	21.40	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.51	0.70	-5.19	10	106	2009-01-15 18:05:59	2004-11-30 09:14:21	7	8	21	0	60	101	0	289.90	33	38.22	CHANGED	RVPSPCLsPIGs.RVuusDK+ssuusSsFNssoSulsESuDLluALSGMNLSsouulct.psh.pSQhpQDV-shpsYhFslQGGpspsNQ.Huahp+uDpuah.........................................+usssstsu.hpuspuSshssGuulss.aQp.hDusN.sh......suYulNPAluSMMtNQLGsuNhsPha-NsuAuSuhussuhDSR.hGuuhsSus...tusS-scNLsRlGNph..uGouLQSshsDPMYhQYLphsp.uAsusAshsDPSh-RNah.GoSYMDhLtlQKAYLuuLLt.QKpQYGlPh..KSuusssHuYYGsPuFG..GhuYPGSPLuoPslPsS.huPsSPlR+uEhNMRas...SuhRNh.GGlMGSWHhDs.sshD-sFuSSLLEEFKSNKTRuFELS	.................................................................................................................................RsPust.sPlGs.+h.s.-.K+s.ss....pt.sos.hs-ss-lhsALSshshS...ssthh...st...tt...uph.p.plpp.pph..hhsh.ssppph.pp.pthhppsp....tt................................................................................................................................tsashsss...suhhhs..phs.ssshss..h-s..s..s.....uuuh.u..sthsSt..Gssh.st.....s.sp..shsthus.....usuhQs..hDPhYhQYhp...s.p.sstt.....hus.tDP.htps.ah.Gsuahsh.t.....hQKAalt.shh....t.QK.......Q..at.......s......pts..s.sYaGs..s.a...shsYsGSPls...sshhssS.hussS.PhRcs-h.shRhs...SshRNh.u..GshG........uWp.-h.t.ph-tshssShLEEFKoNKo+saELu.................................	0	8	34	48
+7822	PF07991	IlvN		Acetohydroxy acid isomeroreductase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Prodom_2380 (release 99.1)	Family	Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.96	0.71	-4.88	45	4225	2012-10-10 17:06:42	2004-11-30 13:30:19	7	7	3943	20	1058	7052	5249	165.30	49	44.30	CHANGED	lL+s.KplAlIGYGSQGHAHAhNLRDSGl.cVllGLRpGu....t.Shc+AcpcGFcVholsEAscpADllMlLlPDEhQspVYcpcIpPNL+cGs..sLsFuHGFNIHas.IpPPcsVDVhMVAPKGPGHhVRcpYpcGtGVPsLlAVa..QDso.GpAh-lALuYAKGIGusRAG	......................................h.lpGKKVAll.G.Y.G.S.Q..G..HA......aAh...NL..R...D........S.......G.l....-......V...s...l..G.L.R.p..G.u...............t....S.a...c....K..A.......c........p........s........G...........F...............c.................V.......h.....o.........l...s...E..........A....s....p...p...A....D...l...l..M...h...L..h..P...D..c..h..Q..u.c..l.a...t..p...c..lp..Pp..L.+pG.s..AL..u...F.u..H.G........F...N....I...H....a........s....t........l...p........s...........p.D.l....DV...hM.......V.AP.K.u.PGHh..V....RcpYp.....c...G.....t.....GVP..sLlAVa..QDs....o.....G....p.......AhslAluYAtulGGsRAG............................................................................................	0	334	687	899
+7823	PF07992	Pyr_redox_2		Pyridine nucleotide-disulphide oxidoreductase	Finn RD	anon	Manual	Domain	This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null --hand HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.67	0.71	-4.44	139	57441	2012-10-10 17:06:42	2004-11-30 13:43:45	9	725	5624	527	15622	68615	26122	259.00	18	57.57	CHANGED	cllllGuGsAGhsAAhpht......phshc.lsll.............pp.sthsh.stsslspphhhpstthht.h....t.h.....................................pphh...tp.tslch............hht.ppshpl..shspt.......................t..h..........hphcplllATG.up.sth.....sls.G..................t.h.hh.ptltsupphhphhph............................sp...cllllGuGhlGlEhAthhpphGtcVsllcttsphhsth.sphttthhpphh..................................................hththhttttstpttsssphtththsstpphpsDhlllulGhpPsschh.....cphGlch..........tp..................pGhI..hl-c.....th..pT.......................s...ssslaAsGDsstht.	.................................................................................................................................cllllGu......G..s.u...Ghs....sAh.t...hs........................pt.s...h....c....l....s..ll.........................................................pt.....s...............s......h.............h.......s....t....l.....s.....p...t...h...h....h....p..s...h..t.h..h....t.....h..............................................................................................................................................phh.t.t.h..t.......p....hs..h..ph.....................................ht......pp...s...h..pl.........thst.t...........................................................................................................t....t.t....p....h....p.h...c...t...l...l.l....A....s...G....u.......p....s.t.h.....................sls.G..........................................t..t....l.........s...s..t...t...h....h..t.h....h.........................................................................................sp.......pls...l...lGuG.huh-hu.hhtths.pshhh.hht.hh............................................................................................................................................................................................................................................................................h.hh.........tt.t......ttttt..hshhhhhhshhsssp.h....tths.l..p..h..........t.p..........................................................p.G...h...l........h..s......s.p..............h..........p.T......................................................................s......hs..s..laA..hGDsht...t........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	5062	9898	13194
+7824	PF07993	NAD_binding_4		Male sterility protein	Griffiths-Jones SR	anon	Pfam-B_1115 (release 6.4)	Family	This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila.  A sequence-related jojoba acyl CoA reductase is also included.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.58	0.70	-5.45	102	3739	2012-10-10 17:06:42	2004-11-30 13:44:47	7	268	1310	1	2010	30893	13882	233.90	23	19.78	CHANGED	lTGuTGFLGphllccLL..cssssh..clasL.VR.upssp....sutpRl.pphhphslap.h..............tp+lpslsGDlspsp...LGLsspshppL..sppl-lllHsAAsVpast..shpp..hhssNVhGTtpllcLAp.........p.h+ph......shhaVST........uhssstpt.th.c.....................................................htp.thshhtshss.sYshoKhhAEhllpptt...sLP....l.....sIhRPuhlsu...................................-shs.G..hhsshc.hhphlhhsht.tGhh.shhss.t.............hshlPVDhVspul	...............................................................................................lTGuT.GF.L...Gt.h......l....l.p......cL....L....p................p.......s.......s...................h......pl.....h...s..L.....l.R.....s...p..p......t...t............t...s........h...p...R.....l.......p.t..h....p.h.t..h....tth............................................hp+.l.p..s.l.s..G...D..l...s..p.......p.........L...G......L.............s....p....t...p.....h....p.t...L........h........p.................p......l..s........h.............l..l..H......s...A.........A........t.......l.......s.......a.......s.......t..............s.....h.....p...p.............h....h....t....s......N.....l....t....G....T..t....p....l....l....c....l...At.......................p..hpph..........thha...l..So........uh..s....s..s......t..t......t...h..............................................................................................................................................................................t.p....t......t..h..h...t....s..h.s...s....sY.....s.t...o...Kh..h....u....E.......h....l....l.........p......p.......t......t.......................................s........l....s..................s...................sl..h..R........s.uh.lsu.......................................................ps.h.s..G....h.h..s...s...h...s.......h....t.h...h.h.......h..s..h.t.....h.....s.....h..h...........t...h....h...s.p........................................hshlPVDhssph.......................................................................................................................................................................................................	1	595	1051	1665
+7825	PF07994	NAD_binding_5		Myo-inositol-1-phosphate synthase	Bashton M, Bateman A	anon	Pfam-B_959 (release 4.1)	Family	This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated  to inositol [1]. Inositol phosphates play an important role in  signal transduction.	25.00	25.00	28.60	28.40	20.90	20.70	hmmbuild  -o /dev/null --hand HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.93	0.70	-4.92	37	1323	2012-10-10 17:06:42	2004-11-30 13:45:19	7	12	949	36	547	1220	416	337.10	33	89.86	CHANGED	ltlhlVGhhGNsuoTllsGlhA.+cshshts............G.lsthushclG...............th.PhhsssshVluGaDI...sshplucshpc....Atshs.slpppltschp.....................shlssspup+hDslhs........tstsphcpspphtpDItcFtcpsslD......phllL.susTEp.........h.......shttl.tshp.sttp.lssSphYAhAul..h......tGssalNusPpssh.sP..uhh-hAccpsl..IsGDDhKoGpTth+osLs.hhlttshcspulsoYNhLGNsDGtsLos.pphRSKchoKSsl.ss.............................................p.hhphphsccssHhssIcYlPhlGDsKhAhDchpuclFhGup.plpl+.sscDShlAuPlllDLlhhsclspc.........................................+shtu.Vhsh.SYahKuPh......stthssh.cQttsl-shlR	.................................................................ltlhllGh.GNsuoolhtGl.h.+ps.s.tt..................lsth..php..hG.....................shhs.s..hhuuaDl...ss...h...pl...upsh....tc.....Ahhhp..s.p.pl.t..ph..........................thlssp...ps.p..h.sslht..........................phpt.pt...DlhchhcpsplD........Vll.hssTtp..................................................hssophYAhAul........tsssF.lNu.Pp.hh.sP.......thhchhpc.tsl..IsGDDhKSt.sthhohhs.hhlhtshtsp..hohph.ssssh..Ls..pp.R.cphphSps.s.................................................ts.h..thttcssHhss.cYlshlsDpKhAhschpuphFhss..slphp.ps.DS..uAslllDhlhhsclutc.............................................cuhtu..lhs.h.uahhKuP..........s..hps....pththlcphh...................................................................................................................	0	192	351	473
+7826	PF07995	GSDH		Glucose / Sorbosone dehydrogenase	Mistry J, Bateman A	anon	Pfam-B_1863 (release 16.0)	Domain	Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.23	0.70	-5.36	164	3525	2012-10-05 17:30:43	2004-11-30 16:29:24	6	176	1857	34	1319	3362	3764	295.30	22	60.71	CHANGED	LcpP...Wul......uFL.P....D.G.ph.LlTER.sGclplls.........sGph..pslsGl........P.pV..........hspG.....QGGLLDlslsPcF..sps........phlYloYu......................tss.....ss.ss...sT.sluRucL..sss.....pLp....shcslact...pPt.hss..stHaGuR.lsFs.....s.....DG.pLalohG-Rtp..........cs......pAQDh...ssphGKllRls.sDGolPsDNPFs........s.........ps..............suts.pIWSYGHRNsQ.GhshcspsGpLWspEHGP+GG......DElNllcsGtNYGWPlloaGhpYs....Gs.................lspt..sspsG.........hppPlh.hWsPo....IAPSGhsaYsG...ct.F.P.p......WcGslhlGuL.p.......sptLhRlpl.c.s...............sp....lsppE+lh.........................tshG.RlRDVppuPD.G.tlYllTD.........tsG...p.........llR	...................................................................................................................................................................h.h.hh.s.......s...t.....t......h.hl....s..p....G.t.lhhht.................ttth..............h.........th...................tl..........................t....s.....p.......t...G....l.h.s..l.s.h....t...P.t....a.....t......p..s.........thh.a.h.hs..........................................................t......ts...tlsph.ph...pts...................p..h...p......s......p....s....l..hp.t...............h.Pt......t..........s.pH...hG.sp...lh.Fs...............s..........-.....G...hLa.l..shG-ssp........................ht..............................tu..ps...h.........p.p......h........t...G...p........l.....l.......R...............l......s.......s...............s...............G..................p............h......s....s......NP.h..............................................................................ts....cl.a..uhGhRNs...............G..huh.......s.......s.......t.......s..........u...p......La...........h..s.....-...h..G......sc.th................................................D...E..l....s...h........l........p......t......G.........t......sY.GW.....Ph..h.t..h....s......p.hs.......................s..........................h.tt.....p.htt.........h......P.....h......h......h.....t.sp.....................u.....s.........G.h...h.....h.h....p...u...........p.........h...s..t.............................ap.tthh....huth..t..................s..plh....hh.h..p.s.........................t............h.h.t....t..hh...............................ttht...R..h....sl....h.......s.....c..G...lhl.ss..............................................................................................................................................................	0	434	842	1113
+7827	PF07996	T4SS		Type IV secretion system proteins	Mistry J	anon	Pfam-B_4497 (release 16.0)	Family	Members of this family  are components of the type IV  secretion system.  They mediate intracellular transfer of macromolecules via a mechanism ancestrally related to that of bacterial conjugation  machineries [1][2].	24.70	24.70	24.80	25.00	24.50	24.60	hmmbuild  --amino -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.17	0.71	-4.45	50	544	2009-01-15 18:05:59	2004-12-01 12:38:11	6	3	398	1	96	471	20	189.20	20	79.43	CHANGED	GIPVhDsus........hhpt....hppltphtpplpp..............hppQlpp.hcp.Ypu....loGscshGslh...sssshppslP.psapslhsth....sshuuluupsptlhpttphhss........tsstppptsptthspsststuhuppsYspsppRlsplppLhppIssspDsKshuDLQsRItsEpshlQs-ps+Lphhphhtpupppltpppppc	.............................................GlPVhDsss..............htph..........hpphtphtpp.lpp.................hppQlpp.hc.......pphpu...............hT.Ghp..sh..sshh.........ps..sh.pphh..s.....ps.hps.l..hssh.......tss.uuhusp.hp.ph.......hp.p..phhs.....................h.spsttptspt.ph....ph...sts.h...s.h..spps.....hppsppchpplppLhpplspsp....D.K..thtDLpsplpsEpshlpsp...php....hph.hpthtps.pp.ph.pppt......................................................................................	0	9	46	67
+7828	PF07997	DUF1694		Protein of unknown function (DUF1694)	Mistry J	anon	Pfam-B_4517 (release 16.0)	Family	This family contains many hypothetical proteins.	25.00	25.00	26.90	32.50	24.60	21.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.25	0.71	-10.41	0.71	-4.17	33	780	2009-01-15 18:05:59	2004-12-01 14:05:26	6	1	736	2	85	413	0	120.90	33	82.58	CHANGED	Mo-p....lccpLppuhaG..ssphcPDE+RpaLGoaRERVllulThsplppppsh..pplpptLpc....hps..hplhlNGplshs.hhspYl+lAsctslpaTlVsspptpo....shGlVls.ucpAlsp-plpl	....................Msc.....lpcpL.cthaG..s.plsPDEQR+YLGTFcERVhltlslspspssplp..pthhphLcs......tps....lplhlssplshs.ttshYlKhApcpssphTIVscpphpo.......shGLllp.uspAVsh-ph-l..............	0	27	50	65
+7829	PF07998	Peptidase_M54	DUF1695; 	Peptidase family M54	Mistry J, Bateman A	anon	Pfam-B_4509 (release 16.0)	Family	This is a family of metallopeptidases.  Two human proteins have been reported to degrade synthetic substrates and peptides [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.41	0.71	-4.54	5	267	2012-10-03 04:41:15	2004-12-01 14:39:37	6	3	198	3	176	401	24	127.40	29	50.09	CHANGED	M-cIAFlYMGGcEacWLFFEVYDRVcRal+DVsLsVslVYAGRIKLPPGhLlRVpstsGalsMYsFEAVVEALYGKLVEM+sDVNDDSlTKIFGITTlPIGSRDpYFDIYKKYLGIpVslGNYsVLuLS..IKPFYTE..N+ELFlERVFKGVLHElGHLYGLSHCss.DCVMNPPsDL+DWD+RuPoYCNsCL+cLKR	.........................................................................................................................................................................................................................................................................h.lh...-ha..........hp..hhhG.....s......thslh.h............h..........................s.t..p..l..h.....h...pRshKps.sHElGHhhGLpHCpp...pClMph.S..so...lp...-sDp+s.p.h.Cs.Chp+Lt......................	1	64	100	138
+7830	PF07999	RHSP		Retrotransposon hot spot protein	Mistry J, Bateman A	anon	Pfam-B_4567 (release 16.0)	Family	Members of this family are retrotransposon hot spot proteins.  They  are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop motif.	19.50	19.50	19.50	19.60	19.20	19.40	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.68	0.70	-5.89	3	829	2012-10-05 12:31:09	2004-12-02 10:36:38	6	4	10	0	349	862	1	307.10	29	57.65	CHANGED	YDSIYNA+WuYVMSGaNsEPLGMKVa...DGEPPchWTcEEVsVSHTP-DhsEP..LPR+GNLEIAVLTSQ+GWPashFh..pcllscDAsc.t..DaVFs.DVYIRREVhRVWalVKpRLspWLpS+Lp-+psPs..VLlGTPGIGKShuVGSFLLY+LLHYDAELLpIIAYsV+G.KAYVFaKsTss+sGpVTFYpchssulcAVc-LuR.....EslKGYIIYDVGKchcpPuPhsPPsGWusIVLoSPDhssYhEWucp+RAlRIhINCs-EsDLKAhsl..W+Klups.t.sPo-A+..plEsEWQEIcGRIcKVGPLLRaIl-.-uSYKtplcKIcEAlsEhScsccpSYhpVFssuspWcscKsochLARlVRV+sE.NGEpCcN...sPlSAYluQKhLshLRsWlspAphNcasuRpulRusttHAA.pFEKsGIaAFoplNsltsIs++LRtLP	.............................................a-SlhpApWpaV.h...p...s........s.....t....................h....G.M.tVh.....t...G...p..............p........Wo.tps..s..............s..............p....t.c..s....p......................t........h..h.hVLoSphGWPat............................................t...c....salppE..RVW.lVcttlstW...h......t...t...............s..h..lll.GTPGIGKShusGShLLapLLHap.......st.L........hVsahh.ts.psalh.ptt.t....pV..hY.tt..shp.lpth.t......................tth..c.GalIhDhstt...........s...........s...t.W.uhlllosPp.ppapta...p.p....t..s....l.hhNC.pt.-h+Ahhs...W.......p.h.t...............................................................t.....................................Wp....l....ctR.hp.VGPl.Ralhs..t.t...a.ttchtthtthlt.h........ht..h..hh.......h..pt...p.lhclVp...t................s..........hs...h...........................................................................................................................	0	183	223	349
+7831	PF08000	bPH_1	DUF1696;	Bacterial PH domain	Mistry J, Bakolitsa C, Bateman A	anon	Pfam-B_4657 (release 16.0)	Domain	This family contains many bacterial hypothetical proteins. The structures of Swiss:A1SD03, PDB:3hsa, and Swiss:A3QB43, PDB:3dcx, show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in  cell envelope stress response [1].	21.50	21.50	21.50	23.30	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.41	0.71	-4.49	55	796	2012-10-04 00:02:25	2004-12-02 12:40:12	6	3	653	16	178	567	35	123.10	36	88.40	CHANGED	MGlhsulhGsuutl..s.sclpcchsslLl...suEplphuaKllRDhhlFTsKRLIllDpQGlTG+Kl-apSlPY+u..IopFSlETA.GpFDLDuELKI.WlSupshPlp........hphp+stslhclppsLAphlh	............................hhpGlhGsuo.h..ssp.p.hpc.cl.t.clLl...csEpl.hu....aKhl....RD....hhlFTs+RLIllDtQGlTGKKspa+S..l..PY+u..IspaSlET....A....G.p.F.D..L..DuELKI.Wluut.p.hslp.........hpF.cp.spslhslppsLsphh..............................................	0	63	119	152
+7832	PF08001	CMV_US		CMV US	Mistry J	anon	Pfam-B_4698 (release 16.0)	Family	This is a family of unique short (US) cytoplasmic glycoproteins which are expressed in cytomegalovirus [1].	21.50	21.50	22.90	24.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.75	0.70	-5.31	8	91	2009-01-15 18:05:59	2004-12-02 13:34:17	6	1	12	0	0	75	0	218.80	30	93.92	CHANGED	Mpl....hhshlhlsshsAlushpsshcE.uhph...hspssstttsR...........phthPPhP.......pt.pVpSpsupCVlcc.GsLsAlWplRGsF.....hP+....shspatsccocthhcltsPct-lsss.hs..lRa.....pVssclsaVhLplhPCppCppha.cCcPphclPWlPhhoShc.DlcRLaaEpRaLplhaVlhlphhthsLL...shhsApslathplthalR.RHt.hh...........ss.p.hp..tcpt	.....................................................hh.hhhhhshhslsh......-.shph....ppsps.ptpc..........hphpLP.hP........pt.pVsSppupCs.lcs.GsLsAsWplcGs...F.....sP+.....shsphhtccust.hh+V.sPphps-.ss.hs..lRh.....pV.s...sclshVhlplhPC.ptCps.a.cCcPphpl.PWlPh.hsS.hp..DlcRLaaEcRaLphhaslhlphshhsLL...hhhlhpshahhhlt.al+.hph..........................s.........................	0	0	0	0
+7833	PF08002	DUF1697		Protein of unknown function (DUF1697)	Mistry J	anon	Pfam-B_4800 (release 16.0)	Family	This family contains many hypothetical bacterial proteins.	23.30	23.30	23.30	24.20	21.00	23.20	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.13	88	961	2009-01-15 18:05:59	2004-12-02 15:33:07	6	2	861	4	233	734	24	130.00	31	75.33	CHANGED	MspYlALLRGINVGGps+ls.Mu-L+shhpshGassVpTYIpSGNllFp.....sppstsplppplcptlccpaGhsssVllhotpclpplhsssPa..tt...tps....pphhlhFlppshst-.thtpltthpst..Echthss...psl.Y	........MtpYhhLLRGINVGG+N+ls.MA....-L+phL.psl.G.h.ppVc..TYIsSGNllFp.....op.......pstspltpclcshlpppasa.t...hshh.lhohp-hpthlpsh.Ph.hpt........-h.......tchplhFhspshshc.....lt...p.l.ts..h.p....hts..Etlhhspt.h................................	0	76	156	197
+7834	PF08003	Methyltransf_9	DUF1698; 	Protein of unknown function (DUF1698)	Mistry J	anon	Pfam-B_4787 (release 16.0)	Family	This family contains many hypothetical proteins.  It also includes two  putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.89	0.70	-5.73	11	1216	2012-10-10 17:06:42	2004-12-02 16:27:41	6	2	1182	0	199	2993	1047	295.80	54	95.83	CHANGED	FYQpIAp.ssLpcWLpTLPsQLssWp.pppHGcat+Wh+sLcpLPphpP-plDLpsu.VoscpcpslupGEpcc.LcplLRthMPWRKGPaslaGlHIDTEWRSDWKWDRVLPHlSPLpsRolLDVGCGsGYHMWRMlGEGAphsVGIDPopLFLCQFEAVR+LLGsDpRAaLLPLGIEQLPt.LpAFDTVFSMGVLYHRRSPLDHLhQLKsQLVpGGELlLETLVI-GDEssVLVPs-RYAQM+NVYFlPSAtALpsWLcKsGFsDVRlVDpslTos-EQRpT-WMpsESLsDaLDPpDsoKTlEGYPAP+RAlllA+K	...............................................................................................hYp.IAp.s.Lp.WLpoL.PtQlst.Wp...pptH.G.htpW...pslch.LP.p...........l.p..P....p.l.D...L..h.p....u.....Vs.scsppsLo..tG..p..h..cc....lcslh+s..L....hPW..R.K....G...PFp.L.....a..G...................lp......I....D..T...E.W....R.....S..D...W...K..W...D.R.V..L..P...........H......l......S...........s....L......s....G...R...o...lLDVGCG...uG....Y....H...h..W...R.M...l..........G...t...G................A..+..h...s...V.G..I..D......P...o....p.......L........F.............L...s...Q...........F..E..........A....l.R...K.........L..L....G.......s......D.......p...........R.......A..+...L..L...P.....L......G....I...E..Q.....L........P.....s.....L..........p.......A......F..D.T.V...F....S..M.G....V...L..Y..H......R.....R..S..P...L.......-..H....L...h....Q.L....K....s.Q.LV..stGE.L.V......L.........E.......T..........L...V....l-............G......D.......c.....................s......s....V......L.....................V....P....s.....D..............R........Y....A...Q......M.......R.......N.....V.......Y......F......I.P.....S.s.A..LKsW...L...cKsGF.h..D..l..Rl.lD...s.s...l....T....os...-....E.QR.+..T..-WM..s..sc.SLsDF...LD...PpD.oKTlEGYPAPpRAlllApK...........................................................................................................	0	46	104	155
+7835	PF08004	DUF1699		Protein of unknown function (DUF1699)	Mistry J	anon	Pfam-B_4896 (release 16.0)	Family	This family contains many archaeal proteins which have very conserved sequences.  	29.20	29.20	30.40	30.30	28.60	29.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.56	0.71	-4.62	13	59	2009-01-15 18:05:59	2004-12-02 16:44:29	6	1	11	0	59	60	0	127.60	53	95.70	CHANGED	MKIRVVSSR-EItsLNsNE+lVHLAFRPSN+DlFpLVcoCP+lElIQlPpSYh+TlSKSIcMFLEMQpIpLlEGDVWGHRKDINEYYsVspsVI-+IpEh+sEGhSsEcIsEKls+EoKLuP-MltYILsp	.........M+IRVVSS+-EI.sLNsNE+lVHLAFRPSNpDlFsLVcpCPclcslQlPpSYh+TlS+SIcMFL-MQtIpL.lEGDVWGHRKDINEYYplspsll-+Ic-L+s-GhosE-ItcKls+EoKLsP-hltYIlp.p............	0	12	35	40
+7836	PF08005	PHR		PHR domain 	Stogios PJ, Finn RD, Mistry J	anon	Stogios PJ	Domain	This domain is called PHR as it was original found in the proteins PAM (Swiss:O75592), highwire (Swiss:Q9NB71) and RPM (Swiss:Q17551) [1].  This domain can be duplicated in the highwire, PFAM and PRM sequence.\	     The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [2].	20.80	20.80	21.00	21.20	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.94	0.71	-4.05	18	549	2009-01-15 18:05:59	2004-12-02 17:17:51	7	40	122	5	326	477	0	142.80	41	14.32	CHANGED	sRFpps...uspWsauup.sDuIpFsVD+c.IhlsGhGLYG.....up...u-YpsplcLh.......................................pcpsclLupscssa.s-u.ssssaclhFccPVplpsshhYsspAplpGsc.SthGssGhppVpssc.......VsFpFpsustusNGTsVpsGQIPEllaYs	............................pRFpps...uspWtYpGp..sDuIp.....F.....uVD+c..IhlsGhG........LYG............ut......u-YpscIclh.........................................................................................cpsssLupspsta...hsDu....suss..atlh..FccPVplpssshYsAs.s.h...l...pG.s.c...Sh.hGpcGhspVpsss.............VsFp...Fp....s.u.st.Ss....N.GTsVps.GQIPpllaY..................................................	0	93	117	219
+7837	PF08006	DUF1700		Protein of unknown function (DUF1700)	Mistry J	anon	Pfam-B_5023 (release 16.0)	Family	This family contains many hypothetical bacterial proteins and two putative membrane proteins (Swiss:Q6GFD0 and Swiss:Q6G806). 	28.30	28.30	28.50	28.50	28.20	28.10	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.97	0.71	-4.98	18	1443	2012-10-01 22:34:14	2004-12-06 14:55:25	6	16	1095	0	127	829	10	161.70	25	81.69	CHANGED	MsKppFLpcLcppLcplPccE+c-ILt-YEpHFh.GtpcGKoEcEIhccLGsP+pIAKElpAp.sIccs...........cppsohpNlh+AlhuslGLulhNhhlllhPhlhllsl...llulhlsuhsh......lhuPllLlhtulhsGhhphhhs..........lFhuIshsGlGlllsllsahlsKhha+Lhl+YL+WNlpllKG	.............................................................Ms+pcaLppLcthL..c.p..L.Pcp.-.p.p-h.hp.YccaFtp.t.t....pG.sE...p-lltpLGsPcp.lAcE.l........h..u...p.....h..t..l.p.pt.....................................p.t..p.....s........p.......p.........h..............p....s..l............h........s....h.........l......u......L.....s.....l...............h..s.............h....h.....h.....l.....h..h..h.....h..h.hh.hh................ll.u.hh.h..h..sh.h.h..............l..h.s.s...h...h.h....l........h..t...s...h...h...h...hh......................lh....h.....u....l..h...h....h..u....hu..h..hhh...h...h..h.............h....hhchh.hhhhhth...h.a......................................................................................................................................	0	46	82	107
+7838	PF08007	Cupin_4	DUF1701; 	Cupin superfamily protein	Mistry J, Bateman A	anon	Pfam-B_5011 (release 16.0)	Family	This family contains many hypothetical proteins that belong to the cupin superfamily.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.29	0.70	-5.19	26	1723	2012-10-10 13:59:34	2004-12-06 16:31:36	7	28	1356	7	547	2097	365	287.10	32	65.62	CHANGED	scpFLccaWp+KPLLI+puhs.....thts.hsss-.LttLupccclsu....Rll...spctspWpsppGPhpp......apphspptWoLLlQulspat.sstpLhpsFcFlPp.WRlDDlMlSa..........ussuG..GVGPHaDpYDVFllQspG++RW+lsp......pss.tphtsc.slphls.h..cshh.DhlLcPGDlLYlPsGhsHpGhu.s..pslsaSlG.hRsPsht-l...............................hsphs-hLhpph.sh...................tthpcst.psh.pssstltss.th.stltthlppllp..sssphtphhsphlsps..phph-.lh...s.h...................ptss...ltphh.csGshL.+pssh+	.............................................................................................................................................h..pFlcc.a.W.Q.K.+.Pl.l........l...+..............p.u.hs..........sa.h....s..s......l.....o.s--.....L.....s.s.L...Ah-p.-lco..................RLl.......sp.p......s.s...p.....W.....p...s.p.pG.P.h...p..p.....................asp.L.s....c.....p.....s....W.o.........LL.VQ.ul..spa.........t.s.s...........t......t.Lh.psFc.....h..lPs..WR.lDDlMlSa..................usP...........GG.....GV...G..P.HhD..p........Y..D...V..F...............l.l..Q......upG.+.RR......WRlGp..................................ph.p....p.p.h......p.....s.....p.......s.....s.l....h.......l.c.....sa...............-s.lh.....D........................L.E.......PGD..lLYlPPGasH.pG..huh-.........suh..saS...l...G....a..R..u...P...s...s..p..-..L....................................................l.s..shs.-a..lhppthst...................thapD.s....t...h....st....tp....s.u....pl....s...p....th...sp....l.....p..phhhph.lp....ps.p.p.h..p.p.ahG.phlops..+hphc......lh......h.....................p.tc......l.phh.tpG..l.t.....................................................................................................................................................	0	189	314	431
+7839	PF08008	Viral_cys_rich		Viral cysteine rich	Mistry J	anon	Pfam-B_4965 (release 16.0)	Domain	Members of this family are polydna viral proteins that contain a cysteine rich motif [1].  Some members of this family have  multiple copies of this domain.	25.00	25.00	27.00	27.00	23.70	22.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.05	0.72	-4.41	15	41	2009-01-15 18:05:59	2004-12-06 17:12:16	7	4	10	2	0	37	0	80.50	32	56.19	CHANGED	phcPsCIs..NacsChtosKPCC.ctpp.opGthsscEalCtcFsuGlCpPlpsIpNlphahELlccLN-TNFpELcppYap.sltpsts	..............t..pssCIs..shp.C..h..pos+PCC.p.pt.p.sphhsc-alChh.FGpG......lCpPlpslpNlphahpLhcplNpTNatELptpYht.sl....p.......	0	0	0	0
+7840	PF08009	CDP-OH_P_tran_2	TOM13; 	CDP-alcohol phosphatidyltransferase 2	Mistry J	anon	Pfam-B_51131 (release 16.0)	Domain	This domain is found on CDP-alcohol phosphatidyltransferases. These enzymes catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	21.50	21.50	21.50	21.90	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.10	0.72	-4.22	14	224	2009-01-15 18:05:59	2004-12-07 09:29:33	6	2	222	0	63	151	42	38.20	40	13.83	CHANGED	Pc.LlLslhlhlslhhAhLIshPWhsLolhullYlholP	........lVlPlllhVslhlAhLlsaPWhoLulsulhYlh.LP	0	16	34	43
+7841	PF08010	Phage_30_3		Bacteriophage protein GP30.3	Mistry J	anon	Pfam-B_5273 (release 16.0)	Family	Proteins in this family are bacteriophage GP30.3 proteins.  Their  function is poorly characterised [1][2].	28.20	28.20	28.90	52.80	27.30	28.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.69	0.71	-4.71	5	72	2009-09-13 17:33:30	2004-12-07 14:05:45	6	1	71	0	3	50	3	149.50	59	98.28	CHANGED	M...DI+SGuuYPSCALSNFAPHsFVhDGVcCASMEGFLQSLKFKNPEMQc+VCuLVGKAAKF+GpKKsWaRsQ...TLYW+GlPhpRpS-AYQpLl-NAYsElu.QNcGFR+ALpAT+sooLTHSMG+s.KpsETVLTEpEFlssLsRLRDpL	.......MSEL.EIRSNF.pWPSCA..LSNFApWPFVMDGIQFGGLEGFLQGCKVKNVE.QQR.RIFGL.SGL.AAQQ...sG..Ru..YARAQD...RGTLFWLGlPFSRYSsAWKELYTNAYFEAAlQN+GFRDALpASKGKlLKH.SMASuLTKcDTILTEuEFIDlLNhLRDpL....	0	0	3	3
+7842	PF08011	DUF1703		Protein of unknown function (DUF1703)	Mistry J	anon	Pfam-B_5377 (release 16.0)	Family	This family contains many hypothetical bacterial proteins.  It has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches [1]. DUF1703 has the predicted secondary structure pattern of the restriction endonuclease-like fold core and contains an additional beta-strand at the C-terminus [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.37	0.72	-4.30	45	1376	2012-10-11 20:44:44	2004-12-07 14:49:26	6	10	264	0	217	1284	64	98.50	27	20.59	CHANGED	thEsaYpsllYuahu...shsaplhsEsposcGRhDlhlp.......s.tshhalhEFK....tt.pptssp........cuLpQI+c+uYuppapsps...cplhplGlsFsscpcslhph	.........................t.tEtaYpshh.hshht....hh..sa..hlpsEhcoupG.R........hDlhlp...........p...pch...sa...l.hEhK..............h..pts.sc....................cAlpQI.ccKpYstthptps..........pplhtlGl.sFsscptpl.........................................................	0	109	189	212
+7843	PF08012	DUF1702		Protein of unknown function (DUF1702)	Mistry J	anon	Pfam-B_5312 (release 16.0)	Family	This family of proteins contains many bacterial proteins that are encoded by the UnbL gene.\	   The function of these proteins is unknown.	25.00	25.00	123.50	123.20	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.93	0.70	-5.81	23	78	2009-01-15 18:05:59	2004-12-07 14:53:09	6	1	51	0	27	85	2	312.60	42	96.17	CHANGED	Ms.shtslRRRlLTPsls....-TphssRGF+hKsssA+cpLEoVGpsFLpGYuaAlEARsss-scptLEplPschRGFAYEGAuMuhulLDuLsssuttR..........lsshLAGc.GstHsYMlaVGlGWAMARLP.RhhWssltss......DPLLRWLsLDGYGFHQAYF+TsRYVcpppRcpsasW..s.spscYssRAlDQGIGRALWFVsGoDP-hVAshlcpFPtsR+uDLauGlGLAATYAGGusssELptLtctAGtaRssLAQGuAFAAEARh+AGhlssHTclAsplLC.GhosppAAslspcsRsssss.sGshPA.YEsWRpcIAsphss	..................httlR+hlLsPsls....psphstRGF........phcss.su.pcpLEslGpsFlpGataAl-up.s.s-spppL-t.ls.schRGFAYEGAuMuhslhDuLss.s..ptpR..........htshLsGt......GptHsYhsYVGlGWAMARLP....RhhWtclhss...................cPLL+WLslDGYGFHpAYF+Ts+aVcppttss.asW.t..s.ssYssRAlDQGIGRALWFltGsDsstVushlppFsssR+uDLauGlGLAATYAGGssts.-LptLtctAGpa..pspLAQGuAFAAcARh+AGhlssHTclAsplLC..GhosppAAplsc-stss....sss.....su.shPA.YEhWRpcItsph.s...	0	11	19	24
+7844	PF08013	Tagatose_6_P_K		Tagatose 6 phosphate kinase	Mistry J	anon	Pfam-B_5149 (release 16.0)	Family	Proteins in this family are tagatose 6 phosphate kinases. 	25.00	25.00	25.00	25.60	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.49	0.70	-6.04	31	1086	2012-10-03 05:58:16	2004-12-07 16:20:22	6	5	720	5	98	655	63	386.40	57	96.98	CHANGED	Mps..L..sLlpp+KsGcshGIhSVCSAHPLVlEAAlcpAhpss.ssVLIEATuNQVNQhGGYTGMTPuDF+caVhplAcchGaPp-+llLGGDHLGPNsWpchPA-pAMspA-sLIpAYVtAGFpKIHLDsSMuCAsDP..ssLsDphlAcRAARLsplAEps....h.pphGtpsslYVIGTEVPlPGG..AtEsLs..plpVTsspAAtpTlpsH+pAFtptGL.ppsasRVIulVVQPGVEFcHpsVlcYcsppApsLophlcs.PthVFEAHSTDYQospAhppLVcDHFAILKVGPuLTFALREALFALstIEsELl...sstppusLtpshEplMhcpPp.WppaYpGssspt+ltR+YShSDRIRYYWscPclpsAlcpLhsNLsspslPLsLlSQYLPtQapulppGcLsscPcsLllc+IpplLpsYttACps	.......................................hppllt.pHKAG.c........phGIhuVCSAH.PLVlEAAlpaspssp.p.lLIEATSNQVsQ..F...G.GYT.G.M.TPADFRpFVhplADplsFsp-.tlILGGDHLGP.....Np.....W.....Q.....p.......sA.s.....tA.Mtpus-LlKuYVtAGFpKIHLDsSMSC.t-DP....lPLs..s-..hV..AE..RAAhLs.....tsAEps.....s...pch.....tc..t.....pLsYV.IGTEVPVPGG..........tt.......ps............lp..p..ltlTps-sAtsTLcsHp+AFttpGL.sthhsRlIAlVVQPGV.EF.DHoslIcYQPtcApALuphl-.pht..hlaEAHSTDYQT.puhppLVtDHFAILKVGPALTFA.............LREAlFuLAtIEpELl.....ss...c...t...p...StlhpVlEcVMLc..cPpYWppaY+ss...h...ssphL......s.........h....t....YS...hS....DRl.....R........YY.WPcspIcsuhtpLhtNLt.sssIPL.slISQYLPhQa....+lppGcL...p...s...tP+pLIhs+I.DlLttY+huCt.t....................................................................................................................................	0	21	45	68
+7845	PF08014	DUF1704		Domain of unknown function (DUF1704)	Mistry J	anon	Pfam-B_5490 (release 16.0)	Domain	This family contains many hypothetical proteins.	21.80	21.80	22.80	22.10	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.88	0.70	-5.42	35	415	2009-09-10 23:48:06	2004-12-07 16:57:52	6	2	337	0	154	362	93	328.70	31	67.85	CHANGED	+ccFhpsphphtPpapY+.......LshDstph+cpLasl.l-plcD....sslppLacchhcphsthlchLpshGo..ccFhatSlclYGsPscphhssAchlLchs.............thtcppscphsAppAschhppphcpa.....thpscVplSsslsAcAhVuusp...lhlspsshFScp-lpsLtpHElGVHllTTlNGppQP.L+hLShGhPssTtTQEGLAlluEahoGuhohpRL+pLAhRVlAl-thhcGtsFh-sFphLpcphshscccAFslTtRVaRGGG......FTKDhlYL+Ghhclhshh+p.hss.....ls.LhsGKhulcclsllp-LhpcGlLssPcalP.........hhps.sshsshhsa..hlsslc	.......................................................................................................................ptF.tt..p.....Pththt.......hshss.t...hptph.tl.hch.pp..........ssltphhtp.hppht.hhphLp..sh........Gp...tFh..S.phYG..t.sscthhtss.hlhphs........................t..ppc.phhsuppsh..p..hh.pphppah........h..phpVpho-sllucA..h..suusp......lplss.....psh.ascp-lpsLhpHEhhVHlhTslNG.....ptQP..h...p....h....h....u....hG.......h.........Psss.....sTQEGLA.lLtE.h.l.s.t.s....hpRh+pL....shRVhA.ls.hh......pttsFhplFphlpcp.....sh................stpsuashssRVaRGussp.........s.sFTKDhlYLcGhlpllpahpp..hpp................hshL.h.sGKsohcDlchlcp..LsppGhltsP+ah.........thhc.hptLpshhpa..hht...p...........................................	0	31	54	100
+7846	PF08015	Pheromone		Fungal mating-type pheromone	Lee SC	anon	Bateman A	Family	This family corresponds to mating-type pheromone proteins. The homobasidiomycetes, or mushroom fungi, have arguably the most complex mating system of all known organisms. Many species possess a mating system known as bifactorial incompatibility, where two unlinked loci control the mating -type of an individual incompatibility loci (the A and  B mating-type loci). Each A mating-type sublocus encodes a pair of divergently transcribed homeodomain transcription  factors while the genes responsible for B mating-type  activity encode lipopeptide pheromones and G-protein -coupled pheromone receptors [1].	21.80	21.80	21.90	23.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.50	0.72	-3.15	38	68	2009-01-15 18:05:59	2004-12-08 15:46:22	6	1	9	0	20	59	0	61.10	24	97.63	CHANGED	MDs..Fss.lshh.........................................h.ssts.......sssstsssphpshssDtERhssG...shsuaCVl	.............MDs..Fso.lshh.................................t......tssss.s.......sssstssssh.slPsstE+hsuu...shsuaCVI........	0	18	20	20
+7847	PF08016	PKD_channel		Polycystin cation channel	Bateman A	anon	Bateman A	Family	This family contains the cation channel region of PKD1 and PKD2 proteins.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.31	0.70	-6.06	13	1249	2012-10-03 11:11:44	2004-12-08 17:04:05	7	121	184	0	812	4460	432	268.20	19	25.62	CHANGED	shuhtslsphpslapahppsLlstl.....puspo.tt.stp....pshlLGsPRLRQlRlcss...hhh.c.hhpphht....Cpsshu.sspDp..a...W....cthspsssthhhYps...........sspL..............shtpaGhlssYs.ouGYhh..Ls.tstppotctlstLpcppWLDppTRAlFl-aohYNsssNLFssloLlhEhPssGsslsshplcohsLhcassshsh.lhlh.llallhhlaashsEhhpltpct.hpYl+.osWNhL-hsllslsslsslltlhRphhssphhpphh.ssstsFhsFcpluphsphhpsltAhLlFLshlKlh+hlpFspshplhopTLpcuhc-lhuhulhlsllhlAYuthuhLlhGophssasshscuhlol.....hphlsssFsas......th.pss+hLGsLhasshhhlhhalLLNlFlulIp-sYspl	......................................................................................................................................s......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...t....h......h..u.....h...h...h.....h....h...h.l.....p....h...h...c...h.l......p...h.......t...p...h......s.......h....h...s......l...p.t...s...h....p...l..h...t.F.h.h..hh..h..ll..h.....hu.a...s..................h..u.....h..........l....l............h...........G...............s..............................h.............................p...............a...............p.............s.....h...p...s.h.....sh..........................ht.h...h.........u....s.............a.t..............................................th.......t.......h...t...............h....h.....u...........l...h.....h..hsa....h....h.h.h....h....h.....hl.ls.hhlull.tsapt..............................................................	1	330	402	599
+7848	PF08017	Fibrinogen_BP		Fibrinogen binding protein 	Mistry J	anon	Pfam-B_4323 (release 16.0)	Domain	Proteins in this family bind to fibrinogen.  Members of this family includes the fibrinogen receptor, FbsA, (Swiss:Q8GIU3) which  mediates platelet aggregation [1].	27.30	27.30	27.40	27.80	26.90	27.20	hmmbuild  -o /dev/null HMM SEED	393	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.92	0.70	-13.56	0.70	-6.26	4	85	2009-01-15 18:05:59	2004-12-09 16:47:47	6	15	47	0	45	87	8	228.40	17	25.45	CHANGED	YMGVLGSTIILGSSPVSAMDSVGNQSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAEN+SQGNVLERRQRDAENRSQGNVLERRQRDsEN+SQGNVLERRQRDsENKSQGNVLERRQRDAENRSQGNVLERRQRDAEN+SQGNVLERRQRDAENRSQGNVLERRQRDsENKSQGNVLERRQRDsEN+SQGNVLERRQRDAENRSQGNVLERRQRDsEN+SQGNVLERRQRDsENKSQGNVLERRQRDAENRSQGNVLERRQRDsEN+SQG................................NVLERRQRDAENKSQVGQLIGKNPLLSKSIISRENNHSSQGDSNKQSFSKKVSQVTNVANRPMLTNNSRTISVINKLPKTGDDQNVIFKLVGFGLILLTSRCGLRRNEN	............................................................................................................................................th.tt.p..tph.....tp..t.ptphttpt....ptph.t+tp.tph.p.t....cs..p....tph.....t.+tptphtt....+tptph......t.+t...ptphttc.s...pt..ph.t+tpp..phptps.......pt........ph.t+tpppspt+sp....tps..t+tpppstppsptp....s.t+tptps.t................ptptph.tptptphttptptph......tptptph.tptpt........ph.tptptth.t.pt...tth....p.th....ptth.....ptth..............................................................................................................................................................................................................................................................................	0	16	19	38
+7849	PF08018	Antimicrobial_1		Frog antimicrobial peptide 	Lee SC	anon	Bateman A	Family	This family includes antimicrobial peptides secreted from skins of frogs. The secretion of antimicrobial peptides from the skins of frogs plays an important role in the self defense of these frogs. Structural characterization of these peptides showed that they belonged to four known families: the brevinin-1 family, the esculentin-2 family, the ranatuerin-2 family and the temporin family [1].	21.20	21.20	21.30	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.51	0.72	-6.65	0.72	-4.04	26	221	2009-01-15 18:05:59	2004-12-09 17:23:23	6	3	48	0	1	216	0	23.70	54	39.09	CHANGED	FLPhlhulAAphlPplhCsIoKKC	.....FLPhlAulAAphlP+laCtIoKKC...	0	1	1	1
+7850	PF08019	DUF1705		Domain of unknown function (DUF1705)	Mistry J	anon	Pfam-B_1101 (release 16.0)	Domain	Some members of this family are putative bacterial membrane proteins. This domain is found immediately N terminal to the sulfatase domain in many sulfatases.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.62	0.71	-4.72	114	2318	2009-01-15 18:05:59	2004-12-10 10:47:59	7	4	1307	0	257	1329	103	149.40	26	27.51	CHANGED	hlhshhshl...hslhuhtalhKPlhhllllhuAhssYah.sYGllhDpsMlpNlhpTssuEAtsllohphllalllhGllP.uhllhplcl...phpshh+tlht+hh....hhlsulhllsslshhhapsauSlhRNp+.pl+thlsPsshlhushpahppphhpp	...............................................l.hh.hh.hl...ls.Lhu.h...hhhh+..hl....u.sl...l....l....l....h....SA...uA....p.Y....ah....h....hY....G.ll...Ispuh.ltslhp.TsssE.upp....ll.o.........ph....lLhllh..hul..L...s.sll..l.hhs+l......phs....h..h....+....s....h..h...h...+...lt.......shll...s.lll...lhhh...s...h....h.....psatthhcs.t..ph.......h..h.P.p.lhu.hphh.......t....................................................	1	40	114	185
+7851	PF08020	DUF1706		Protein of unknown function (DUF1706)   	Mistry J	anon	Pfam-B_5540 (release 16.0)	Family	This family contains many hypothetical proteins from bacteria  and yeast.	20.60	20.60	20.90	20.80	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.92	0.71	-4.75	42	927	2012-10-02 14:44:17	2004-12-10 11:49:08	6	4	794	0	99	520	21	149.80	35	96.98	CHANGED	M.spspoKp-LltslppsapKlhs.hsslPcchpppth..t..........ts-+osp-hluYLlGWtpLlLpWhppp..ppGhtVthPspsYKWNpLGtLsppFaccYpph.shpchhthLppshpclhpLI-shSs-ELFsts.htWs......upWslG+alphNTsSPacshppKlR....+apKt	.............Mtp.psKpELhtthppsapKhht.hsslscp..tpp.h...............phD+s.t-slsa.htWppL.lLpW.p..sp....ppGh.ps.hPs..ptapW...pp...hGtL.p.Fhppatph.olpphhthLppshpplhthI-shSp-ELFp..phhtWs......ushslhpahh.sTsu.ashhtpKlR+apK.h.....................	1	33	66	80
+7852	PF08021	FAD_binding_9		Siderophore-interacting FAD-binding domain	Finn RD	anon	Manual	Domain	\N	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.45	0.71	-4.13	40	1962	2012-10-03 00:38:56	2004-12-10 14:18:49	6	12	1325	1	503	1509	90	109.60	34	37.53	CHANGED	pVhpspcloPphtRlshsG.ssLssas..ss.ssDpalKLhFPpsuts.s.h.......ths.th........tt.+PhhRsYTlRphDssst....El-lDFVlH...ss........GPAusWAtpApsGDpltlsG.P.tush	..............................................pVhcspplosphhRlsls.G.....p......s......Lss.Fs...........st..shDs.al.KlhF...Pp...sssph...................h..st....t...hh....h.......stt.+Ps.RsYTsRth..Dt..t..tt...........ElslDFsl.H.....ss............................GsAusW.A.tp.Aps.GDplslsG.Ptut.h.............................	1	122	319	431
+7853	PF08022	FAD_binding_8		FAD-binding domain	Finn RD	anon	Pfam-B_728 (release 4.2)	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.67	0.72	-4.16	19	2729	2012-10-03 00:38:56	2004-12-10 14:19:05	7	89	751	1	1659	2722	95	111.30	22	16.74	CHANGED	hhssph.hpltlhs......ssllplphsKPpt....a+apsGpahalph..slo......phHPFoI.sSust........s-tlslhI+spusaTcpLpphhtp...............................................sthsph.+lhl-GPYGssu	........................................ht.......ph..hhs......ss.s..h.c..l.ph..p..p.sp.................hpacs...G.Qal..a.....lph...s..........s.........lu.....................p...........H.......PFT.l......s.S.s..s.p...................................p..s....t..l...sl....h..l..+s........h....G..s..a....Tpp.Lhphh...t.tt................................................................................................................................pl....hl-GPaGt..s.....................................................................................................................................................................	0	436	875	1356
+7854	PF08023	Antimicrobial_2		Frog antimicrobial peptide 	Lee SC	anon	Bateman A	Family	This family consists of the major classes of antimicrobial peptides secreted from the skin of frogs that  protect the frogs against invading microbes. They are typically between 10-50 amino acids long and are derived from proteolytic cleavage of larger precursors. Major classes of peptides such  esculentin, gaegurin, brevinin, rugosin and ranatuerin are included in this family [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.33	0.72	-3.63	18	473	2009-01-15 18:05:59	2004-12-10 16:58:22	7	2	54	1	0	469	0	32.20	38	49.17	CHANGED	GlLsslKthAKssu....KslApshLsplsCKlotpC	..........GlhsslKshu....tssu....Kss....utslLcpluCKloppC...	0	0	0	0
+7855	PF08024	Antimicrobial_4		Ant antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the ponericin family of antimicrobial peptides isolated from predatory ant Pachycondyla goeldii. The ponericin peptides may adopt amphipathic alpha-helical structure in polar environments. In the ant colony, these peptides exhibit a defensive role against microbial pathogens  arising from prey introduction and/or ingestion [1].	25.00	25.00	26.90	34.40	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.60	0.72	-6.65	0.72	-4.06	5	7	2009-01-15 18:05:59	2004-12-15 11:27:15	6	1	3	0	0	7	0	23.40	51	94.80	CHANGED	WGoLlKhGlKLlPSVVGhFpKKKQ	WGohhKhuhKLlPuVlGhh.KKKp.	0	0	0	0
+7856	PF08025	Antimicrobial_3		Spider antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family includes antimicrobial peptides isolated from the crude venom of the wolf spider Oxyopes kitabensis. These peptides, known as oxyopinins, are the largest linear cationic amphipathic peptides chemically characterised and exhibit disrupting activities towards biological membranes [1].	25.00	25.00	88.20	88.10	19.50	15.60	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.69	0.72	-4.23	2	4	2009-01-15 18:05:59	2004-12-15 11:46:53	6	1	1	0	0	4	0	37.00	84	100.00	CHANGED	GKhSshuKlLRuIAKhFKGVGKsRKQFKpASDLDKNQ	GKFSsFuKILRSIAKhFKGVGKVRKQFKpASDLDKNQ	0	0	0	0
+7857	PF08026	Antimicrobial_5		Bee antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family consists of antimicrobial peptides produced by bees. These peptides have strong antimicrobial and some anti-fungal activity and has homology to abaecin which is the largest proline-rich antimicrobial peptide isolated from European bumblebee Bombus pascuorum [1].	25.00	25.00	28.50	27.90	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.20	0.72	-4.10	2	26	2009-01-15 18:05:59	2004-12-15 11:48:51	6	1	20	0	4	21	0	33.30	73	63.28	CHANGED	aVPh.NsPpPGp.+PFPoFPGpGPFNPKIpWP......Ga	.....Pl.psP.PGt.KPFPTFPGQGPaNPKI+hP..........	0	1	1	4
+7858	PF08027	Albumin_I		Albumin I	Finn RD	anon	Pfam-B_100627 (release 16.0)	Domain	The albumin I protein, a hormone-like peptide, stimulates kinase activity upon binding a membrane bound 43 kDa receptor. The structure of this domain reveals a knottin like fold, comprise of three beta strands [1].	20.20	20.20	23.00	22.70	18.20	17.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-11.06	0.71	-4.37	4	79	2012-10-01 22:06:18	2004-12-16 13:53:21	6	3	23	2	3	89	0	96.10	46	81.40	CHANGED	LsVFLlAshoL.hFspK.luAsDCsGsCSPFEMPPCtSSsCRCIPlGLlsGaChpPSu.solhKMV-EHPNLCQScADCpKKGSGsFCARYPNPDIEYGWCFuSsSEA.-VFhpl...P..RshhK	.................hhlhh..h.h..hp.htA..Cs.s..h...Cosat..h.s.sCt.o.s..s.....CR.C..lPh....sL.h.......sGh.Ch.Po.u....shsKhl-EHPNLCQScs-ChKKGSGNFCARYPNs.lcaGWCFtu.u-u..................................	0	0	3	3
+7859	PF08028	Acyl-CoA_dh_2		Acyl-CoA dehydrogenase, C-terminal domain	Finn RD	anon	Pfam-B_8101 (release 16.0)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.41	0.71	-3.91	37	2598	2012-10-01 23:33:27	2004-12-17 10:14:48	6	16	1047	24	864	19514	7084	132.50	23	33.66	CHANGED	lshuussLGhA+uALssah-hsp.sRhp.....hsssths-pshsthplAcussclcAAchhl.csspt........scsGpth.s.t.pscspts....puhAschshsussplhpsuGupuhhpssPlQRhaRDl+ssssHshhs.	........................................................................................h..hsushl..Gl...A...cu...A......hc...t.......sh.p...hs....p..p+sp.............tusst..p..h...s....c....c..P......h..............s..........tp..l..G...c......h.......p.s...p.l...p....u....A...cs...h...l...h...p..s.u..c...t...h..p.t.h...................ht.p...s...p..t.....h......s..........t......t...p.....s......p..s..p..hs.............................ps.h..ss.chu....lp.s........s....s.p....l....ac.....h..sG.up.u.h.t.......t.......s..........p..........s...L...pRa......aRss+sh..Hs....s.............................................	0	165	466	687
+7860	PF08029	HisG_C		HisG, C-terminal domain	Finn RD	anon	Pfam-B_1550 (release 16.0)	Domain	\N	22.80	22.80	22.90	27.60	21.60	22.10	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.30	0.72	-4.04	39	1973	2012-10-01 21:59:08	2004-12-17 12:10:15	6	7	1931	6	566	1247	328	75.80	44	25.62	CHANGED	tApphhhlhhNsPpspL-clht......lhPGhcuPTlosL.....scp..salAVpshlsccplhclhscL+plGApsIlVhsIpph	..................pA+cp+hlhhcsPp-+L-clhu.........lLPGhEsPTlhPL.............u-p.....phVAl+hVssEshha-sM-cLKslGApuILVhPIEKh......	0	177	364	489
+7861	PF08030	NAD_binding_6		Ferric reductase NAD binding domain	Finn RD	anon	Manual	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null --hand HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.09	0.71	-4.32	21	2341	2012-10-02 19:13:12	2004-12-17 14:53:52	7	96	341	1	1603	3081	161	162.10	21	23.27	CHANGED	a-sllLluuGhGloshlSllp-lhpp.p..................................hctpphpFhWlsRc.uslchact.h..sEltphcpp.....plclcsYhTu.hps...............ssspsthhp......hpshp.......................................................................pthps......ht.........................sphphu.RPNhcpllpch.........tpsssplGVhsC....Gssshsccl+phss	..................................................................................................................................................................................................................................acsslLlu..uGhGlTshhullp...s..lh..pphp..............................................................................................tt.t..h.t.h.c..+..lh....h.lW.lsR.....c.tp..p.h....c.W.h.........t..s..h.h...........pplt..p.........tpp...............thl.p...l.p..h.....a..l..Tp......pp..................................................................tsh.ps.........................t.....................................................................................................................................................................................................p.........t...p.......................................................hph.ph.G..R.P.sh..pp.h.h.pph....................................t...p.......t...t....p....l..uV...hhC....GP.shspplcphs.t....................................................................................................................................................................................................	0	440	839	1305
+7862	PF08031	BBE		Berberine and berberine like 	Mistry J	anon	Pfam-B_649 (release 16.0)	Domain	This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids.  They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine [1][2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.32	0.72	-4.05	67	2389	2012-10-02 00:48:38	2004-12-20 08:43:13	7	38	719	49	1461	2372	41	47.30	32	9.22	CHANGED	uYlNahDhDls..........................asppYat.sN.apRLhplKspa..DPsNhF+ppQSIs	...................................sYlNah.-.h.s.s................................sa...tpt.aaG...sN....as....RLtplKp+a..DPpslF.p.....psl.............	0	342	871	1216
+7863	PF01238	PMI_typeI		Phosphomannose isomerase type I	Finn RD, Bateman A	anon	Prosite	Family	This is a family of Phosphomannose isomerase type I enzymes (EC 5.3.1.8).	20.20	20.20	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.26	0.70	-5.49	8	4066	2012-10-10 13:59:34	2004-12-31 11:15:28	16	20	2915	8	847	2789	266	273.80	26	82.30	CHANGED	LF+LpsuhppYsWG.hGspSAlAchhuho...sPS...lttsKPYAELWMG.THPpuPS+..lhssp.....l+slshsphhAhhsEslu....c+a..uu..pLPFLFKVLSlccsLSIQsHPsKc.uch..........LHstsP+NYPD-NHKPEhuIAlTsFcuhCGF+.htplsp.LtpssElpplIsscsusphppshph.s..ts.-shp.ph.lLpslFuplhsoss-clpppsshLlcptpsps....ushpthD........hsplIpRLpp.aPsDlGlFs..hhLNhhcLpsGEAhFLc..........AssPHAYlpGDhlECMAsSDNsVRAGhTPKahDVssLspMLsYpapss...-ctcht....pc...shhpu........SlLasP.Plt-Fulhps...slc..sGcphl.sh.susSILlsstGsuplhsusp	.........................................................................Lps..hp.phhW.......G..............stltp..h.h...u..hp.........Ps................ps...hu.EhW.....hh..AH.Pp.u.s......St.......l.h...sut........................hps.h.....h...h...s..p..h.....h.....s...........h.....t..c.h.h.s.........................p.p.h......sp........hPh...LhK.........lLsAppsLSlQVHPs.......................................................c.......s......Yt........t....H....c.s..Ehs.....................ps.s...ha..................h........p..ht...h.s.p.l.l.............s......h.....t.s..t....p...h....t...........t.h..........h.......t...h...........p.............pt.h........htt............F.....hl....s.s.......s.......c.......t.....t....t.h..hh.l....h....p....t........p...s...p.s............sp..h...h...............................h....h............t.....s.u..h............h.....................s..........sh...........................................h....s....hh.t.....................................................................................................................................................................................................t...................................................................................................................................................................................................................	0	291	516	721
+7864	PF08032	SpoU_sub_bind		RNA 2'-O ribose methyltransferase substrate binding	Finn RD	anon	Pfam-B_742 (release 16.0)	Domain	This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.37	0.72	-3.81	127	7167	2012-10-10 14:40:03	2005-01-04 15:00:01	7	11	4492	7	1567	4691	2075	74.30	22	27.20	CHANGED	hlhGh+sVhcALps...t..p...lpcl..alpps.....t.p.........plhphsppp..sltlthlscpt.Lsplst.sssHQGllAhlp.hphh	..............................................hlhGh+sVppuLps............s..p......lpcl..altcs.......tstp..............h..ppll.phhppp.......tl...t......l.p...h..l....sc..p.t....Ls..p.....h...u.........s...s.......s...s.....HQ.....Glhuhlp.h...t....................	0	500	998	1314
+7865	PF08033	Sec23_BS		Sec23/Sec24 beta-sandwich domain	Finn RD	anon	Manual	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.06	0.72	-3.47	141	1441	2009-01-15 18:05:59	2005-01-05 11:01:17	7	32	326	24	954	1393	15	91.90	29	10.61	CHANGED	uapushcl+sSpsl+lsshhGshhst........s........................sss..hphsslssspohslhh....ch................................stp..lstt.ptsalQhshhYpss.sG.p+RlRVpTlshshs	.........................uFpAshclRsS.p.s......l..+lsshh.Gshhst..............s...........................................sss....hph..ssls.scpshu.l.hch................................sss....lsps..stshh....QhshhYoss..sG.p.RRlRVpTlshsh............................	0	314	512	772
+7866	PF08034	TES		Trematode eggshell synthesis protein	Ebersberger I, Finn RD	anon	Ebersberger I	Domain	This domain has been identified in a number of distantly related species  of trematodes. This protein domain is crucial for eggshell synthesis in trematodes (Ebersberger I).	21.20	21.20	21.40	22.20	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.18	0.72	-3.90	13	56	2009-01-15 18:05:59	2005-01-05 16:40:20	6	1	7	0	17	90	0	66.20	37	27.38	CHANGED	hpucGcFtupGspccGspappsTpF++GGGhDpYG+K+pa.scY-ThGphK+Yusphhps+FDlhGpL	............pu+G+hpupGptchGsp.ppsTpFphtGthspYG++.K.pa.ucacTpG+.KKYuc+hhcs+FDlhGsL..........	0	17	17	17
+7867	PF08035	Op_neuropeptide		Opioids neuropeptide	Bateman A, Lee SC	anon	Prosite	Family	This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.	20.40	20.40	20.40	22.50	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.24	0.72	-4.37	14	584	2009-01-15 18:05:59	2005-01-07 15:32:49	6	5	291	0	25	585	0	23.60	87	11.63	CHANGED	YGGFM+s..ERuQ.pPLlTLFKNlhhKss.cp	..YGGFMTP..ERSQ.TPLhTLFKNsIlK.........	0	1	4	9
+7868	PF08036	Antimicrobial_6		Diapausin family of antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family consists of diapausin-related antimicrobial peptides. Diapause during periods of environmental adversity is an essential part of the life cycle of many organisms with the molecular basis being different among animals.  Diapause-specific peptides provide anti-fungal activity and act as N-type voltage-gated calcium channel blocker [1].	25.00	25.00	27.90	29.50	20.00	17.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.27	0.72	-4.20	3	10	2009-01-15 18:05:59	2005-01-07 16:23:30	6	1	6	1	5	5	0	39.60	52	63.36	CHANGED	VRVGPCDQVCSRIsPEKDECCRAHG+uGHAoCShGGMpC	..VRVtsCDpVCuRIssERDECCRAHGY.pGh..u...CpsGph.C.............	0	5	5	5
+7869	PF08037	Attractin		Attractin family	Lee SC	anon	Short protein clustering	Family	This family consists of the attractin family of water-borne pheromone. Mate attraction in Aplysia  involves a long-distance water-borne signal in  the form of the attractin peptide, that is released  during egg laying. These peptides contain 6 conserved  cysteines and are folded into 2 antiparallel helices.  The second helix contains the IEECKTS sequence conserved in Aplysia attractins [1].	25.00	25.00	28.80	93.30	18.40	17.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.11	0.72	-4.19	2	5	2009-01-15 18:05:59	2005-01-07 16:32:56	6	1	5	1	0	6	0	54.20	59	89.14	CHANGED	CDIt.hTSpCpMpapsCt-AsuCsslIEECKTSh.EcC..pphpSstuSTTltPp	CDIGNITSQCcMQHQNCuDAsGCsTlIEECKTSMVERCQNQpF-SuSuSTTLGPQ	0	0	0	0
+7870	PF08038	Tom7		TOM7 family	Lee SC	anon	Short protein clustering	Family	This family consists of TOM7 family of mitochondrial import receptors. TOM7 forms part of the translocase of the outer mitochondrial membrane (TOM) complex and it appears to function as a modulator of the dynamics of the mitochondrial protein transport machinery by promoting the dissociation of subunits of the outer membrane translocase [1].	21.20	21.20	23.10	23.40	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.98	0.72	-4.50	24	216	2009-01-15 18:05:59	2005-01-07 16:46:53	7	6	183	0	140	201	0	41.70	39	54.60	CHANGED	KERlshlhchu+sssHYGaIPLllYLGhspsss...P.......olhpLL	..........K-Rlsplhchu+sshHaGFIPhVlYLGappssss....P.......olhpLL..................	0	39	70	116
+7871	PF08039	Mit_proteolip	Mit_preoteolip; 	Mitochondrial proteolipid	Lee SC	anon	Short protein clustering	Family	This family consists of proteins with similarity to the mitochondrial proteolipids. Mitochondrial proteolipid consists of about 60 amino acids residues and is about 6.8 kDa in size [1].	25.00	25.00	25.90	25.80	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.94	0.72	-3.99	2	43	2009-01-15 18:05:59	2005-01-07 16:49:16	6	1	26	0	17	44	0	55.50	65	94.05	CHANGED	MLQSlIKplWIPMKPYYTpsYQEIWlGhGLMuaIVYKIRuADKRSKALKASusAP..GHH	.......MLQSlIKNVWlPMKPYYTQVYQEIWVGMGLMuaIVYKIRSADKRSKALKu.u.sAP..GH..........	0	2	2	4
+7872	PF08040	NADH_oxidored		MNLL subunit	Lee SC	anon	Short protein clustering	Family	This family consists of the MNLL subunits of NADH-ubiquinone  oxidoreductase complex. NADH-ubiquinone oxidoreductase is involved in the transfer of electrons from NADH to the electron  transport chain. This oxidation of NADH is coupled to proton  transfer across the membrane, generating a proton motive force  that is utilised for the synthesis of ATP [1]. MNLL subunit is   one of the many subunits found in the complex and it contains  a mitochondrial import sequence. However, the role of MNLL  subunit is unclear [2].	20.00	20.00	20.30	33.40	19.90	16.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.81	0.72	-4.35	5	67	2009-01-15 18:05:59	2005-01-07 16:50:39	6	1	53	0	33	69	0	56.50	50	88.18	CHANGED	MVNLhthsR-HWValLVPL.GFVlGpYLDRppDERLTAFRNKSALYutRELKPGE-sTWK	..................hshhthhp-+WlallVPh...GF...llGpYLD++pDE+LTsFRNKShLat.R..-LpPsEcsoW.....	0	7	10	21
+7873	PF08041	PetM		PetM family of cytochrome b6f complex subunit 7	Lee SC	anon	Short protein clustering	Family	This family consists of the PetM family of cytochrome b6f complex subunit IV. The cytochrome b6f complex consists of 7 subunits and contains 2 beta hemes and 1 chlorophyll alpha per cytochrome f. It is highly active in transferring electrons from decylplastoquinol to oxidised plastocyanin [1].	23.30	23.30	29.40	28.80	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.13	0.72	-4.46	21	131	2009-01-15 18:05:59	2005-01-07 16:53:32	6	2	113	9	56	116	5	31.40	46	45.33	CHANGED	uE..IhssAslshsLlLlGLuhGFhLLKl.Q...G..E	......uE...IFssAslhhsLlLVGLAlGFlLLKl.Q...u...t......	0	15	41	53
+7874	PF08042	PqqA		PqqA family	Lee SC	anon	Short protein clustering	Family	This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group  of many quinoproteins catalysing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are  unclear [1].	21.10	21.10	21.40	22.70	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.97	0.72	-6.22	0.72	-4.20	26	215	2009-01-15 18:05:59	2005-01-07 17:13:00	6	1	181	0	84	150	7	20.90	53	63.51	CHANGED	M...........tWspPphs-lplGhElshY	..................M...........tWo+Psas-lRlGhEVThY.	0	19	39	63
+7875	PF08043	Xin	Actin_bind_SAA; 	Xin repeat	Wu X, Finn RD	anon	Wu X	Repeat	The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD.  This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats.  Direct evidence for binding to and stabilising F-actin has been found [1] in the human protein Swiss:Q702N9. The homologues in mouse and chicken localise in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localise with Vinculin which is known to attach the actin to the cytoplasmic membrane [1]. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC [4]. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.	20.00	20.00	23.60	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.10	0.74	-6.17	0.74	-3.83	60	1090	2009-01-15 18:05:59	2005-01-10 11:10:43	7	19	36	0	561	928	0	16.00	62	7.03	CHANGED	GDVpss+alFETpPLD	..GDV+os+WLFETQPLD.	0	22	78	230
+7876	PF08044	DUF1707		Domain of unknown function (DUF1707)	Lai X, Finn RD	anon	Lai X	Domain	This domain is found in a variety of Actinomycetales proteins.  All of  the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function  of this domain.	26.30	26.30	26.50	26.40	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.39	0.72	-4.21	59	938	2009-09-10 22:21:14	2005-01-10 16:55:33	6	10	341	0	294	719	4	52.70	37	25.50	CHANGED	hRsuDsDRppssphLspAhAcGpLshsEa-cRlstAhsAcThu-LssLhsDLP	....hRsuDs-RcpshphLpsAhucGcLshsEa--RlspAhtApThu-LsslhsDLP....	0	125	230	276
+7877	PF08045	CDC14		Cell division control protein 14, SIN component	Wood V, Mistry J	anon	manual	Family	Cdc14 is a component of the septation initiation network (SIN) and is required for the localisation and activity of Sid1.  Sid1 is a protein kinase that localises asymmetrically to one spindle pole body (SPB) in anaphase disappears prior to cell separation [1] [2].	20.40	20.40	20.40	21.00	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.72	0.70	-5.26	13	152	2009-01-15 18:05:59	2005-01-11 12:58:53	6	7	134	0	108	153	0	243.70	30	80.45	CHANGED	MEslLupuhDpLsopcsscIppGL+Ql-ulLuplshshsptppssh.............................tsssuhcE.FhpLQ-uFpaNlA..p+Llssl-hlhspss..pu......psshLlhs.lcLlQGlLLLHPsSRslFu.RctsMshlLcLL.............csssssslpsuslpTLlshLLcsPsNhRsFEclsGLtplsphFKhpps............................sp-l....+hKIlEFLhFYLhsEssshs.............................psttstt..t.t.......p+TspEKppLlt+hhsp.l-uLV--Lp-hpsh	.......................................................................................................................................h.hthp.L..p.....pl+pGL+pscuhLuplphpt.p..t....t......pt....s..........................p.lt..hp.ps.uh.p-.F.hLQc.sF..paNlt........cLls.s.......L...-..clhupt.s..ph.............psDhl..l...hssLcllQGshLLHPsS+sLFs.+chhhpl.LLcLL......................................ps.s.s..sslQuu.sL.oLlshLlDsPsNpR.sFEphsGL.pVssLhKp+ps............................sccl+hKllEFLhhYLhsE.s..s................................................................................p..hh..............................................................................	0	29	63	93
+7878	PF08046	IlvGEDA_leader		IlvGEDA operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leader peptides of ilvGEDA  operon. The expression of the ilvGEDA operon of E coli  K-12 is multivalently controlled by the three branched -chain amino acids. Regulation is thought to occur by  attenuation of transcription in response to the changing  levels of the cognate tRNAs. Transcription of this operon  is usually terminated at the end of the leader (regulatory)  region [1].	25.00	25.00	49.30	49.30	17.90	17.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.31	0.72	-7.59	0.72	-4.80	2	92	2009-09-11 14:17:33	2005-01-11 13:56:14	6	1	92	0	8	16	0	31.90	94	95.19	CHANGED	MphllQVIsLVlISVVVIIIPPCGAALGRhKA	.MTALLRVISLVVISVVVIIIPPCGAALGRGKA.	0	1	4	6
+7879	PF08047	His_leader		Histidine operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leader peptide of  the histidine (his) operon. The his operon contains  all the genes necessary for histidine biosynthesis.  The region corresponding to the untranslated 5' end  of the transcript, named the his leader region, displays  the typical features of the T box transcriptional  attenuation mechanism which is involved in the regulation  of many amino acid biosynthetic operons [1].	25.00	25.00	32.40	32.30	17.00	14.90	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.31	0.72	-6.69	0.72	-4.51	4	51	2009-01-15 18:05:59	2005-01-11 13:57:05	6	1	50	0	5	10	0	15.70	96	100.00	CHANGED	MsRVQFKpHHHHHHPD	MTRVQFKHHHHHHHPD	0	1	2	4
+7880	PF08048	RepA1_leader		Tap RepA1 leader peptide	Lee SC, Rossi R	anon	Short protein clustering	Family	This family consists of the RepA1 leader peptides.  The frequency of replication of IncFII plasmid NR1 during the cell division cycle is regulated by the control of the synthesis of the plasmid-specific replication initiation protein (RepA1). When RepA1 is synthesised, it binds to the plasmid replication origin (ori) and effects the assembly of a replication complex composed of host proteins that mediate the replication of the plasmid [1]. The tap gene encodes a 24-amino acids protein. The translation of tap is required for translation of repA.	25.00	25.00	31.00	38.80	16.60	15.50	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.84	0.72	-6.96	0.72	-3.89	5	34	2009-01-15 18:05:59	2005-01-11 13:58:01	7	1	28	0	2	20	0	24.40	70	100.00	CHANGED	MLRKlQYhFLCHLLLPCNISAGRCD	MhtKlQ.hFLppLLL.CIVSAGhCD.	0	0	0	2
+7881	PF08049	IlvB_leader		IlvB leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leader peptides of the ilvB operon. This region encodes a potential leader polypeptide containing 32 amino acids, 12 of which are the regulatory amino acids valine and leucine. A model for the multivalent regulation of this operon by valyl- and leucyl-tRNA is proposed on the basis of the mutually exclusive formation of five strong stem-and-loop structures in the leader mRNA [1].	25.00	25.00	33.50	31.20	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.66	0.72	-4.20	4	116	2009-01-15 18:05:59	2005-01-11 13:59:13	6	1	113	0	11	28	0	31.90	83	99.14	CHANGED	MNsShhNusLLsTA.sAAVVVVRVVVVVGNAP	............MssSMlNApLL.sTAPSAAVVVVRV...V..VVVGNAP	0	1	4	7
+7882	PF08050	Tet_res_leader		Tetracycline resistance leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tetracycline resistance leader peptide. The presence of 3 inverted repeats  which can form 2 different conformations of mRNA  suggests that the tetracycline resistance (TcR) region is regulated by a translational attenuation mechanism. A Rho-independent transcriptional terminator structure is present immediately after the translational stop codon  of the TET protein [1].	16.30	16.30	16.30	16.30	16.20	16.10	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.11	0.72	-6.36	0.72	-4.32	4	14	2009-01-15 18:05:59	2005-01-11 14:00:00	7	2	12	0	2	9	0	18.50	79	22.44	CHANGED	MKCpKMNRVQLKEGSVSMsL	MKCNECNRVQLKEGSVShsL.	2	1	1	2
+7883	PF08051	Ery_res_leader1		Erythromycin resistance leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of erythromycin resistance gene leader peptides.  These leader peptides are involved in the translational attenuation of erythromycin resistance genes. Interestingly, the consensus sequence of peptides conferring erythromycin resistance is similar to that of the leader peptides, thus indicating that a similar type of interaction between the nascent peptide and antibiotics can occur in both cases [1]. This family also includes a small number of regions from within larger proteins from actinomycetes.	22.80	22.80	23.10	23.10	22.60	21.00	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.79	0.73	-6.06	0.73	-4.12	10	16	2009-01-15 18:05:59	2005-01-11 14:00:36	6	2	13	0	8	11	0	15.00	72	8.77	CHANGED	MLISGTAFLRLRTNR	hhhSGsAaLRLRTsR	0	1	4	6
+7884	PF08052	PyrBI_leader		PyrBI operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the pyrBI operon leader peptides. The expression of the pyrBI operon, which encodes the subunits of the pyrimidine biosynthetic enzyme aspartate transcarbamylase.  is regulated primarily through a UTP-sensitive transcriptional attenuation control mechanism.  In this mechanism, the concentration of UTP determines the extent of coupling between transcription and translation within the pyrBI leader region, hence determining the level of rho-independent transcriptional termination at an attenuator preceding the pyrB gene [1].	25.00	25.00	34.20	34.20	17.90	15.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.20	0.72	-4.15	2	185	2009-01-15 18:05:59	2005-01-11 14:01:14	6	1	184	0	5	32	0	38.10	90	91.70	CHANGED	MVQCVRHFVLPRLKKDAGLPFFFPLITHSQPLNRGAFFC.GVRR	MVQCVRH.VLPRLKKDAGLPFFFPL.hT.popPLN..................	0	1	1	5
+7885	PF08053	Tna_leader		Tryptophanese operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tryptophanese (tna) operon leader peptide. Tna catalyses the degradation of L-tryptophan to indole, pyruvate and ammonia, enabling the bacteria to utilise tryptophan as a source of carbon, nitrogen and energy.  The tna operon of E. coli contains two major structural genes, tnaA and tnaB. Preceding tnaA in the tna operon is a 319 -nucleotide transcribed regulatory region that contains the coding region for a 24-residue leader peptide, TnaC. The RNA sequence in the vicinity of the tnaC stop codon is rich in Cytidylate residues which is required for efficient Rho -dependent termination in the leader region of the tna operon [1].	25.00	25.00	70.80	70.70	17.20	16.70	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.78	0.72	-6.97	0.72	-4.56	2	48	2009-01-15 18:05:59	2005-01-11 14:01:50	6	1	46	0	2	6	0	24.00	99	98.63	CHANGED	MNILHlCVTSKWFNIDNKIVDHRP	MNILHICVTSKWFNIDNKIVDHRP	0	1	1	1
+7886	PF08054	Leu_leader		Leucine operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leucine operon leader peptide. The leucine operon is involved in the control of the biosynthesis of leucine. Four adjacent leucine codons within the leucine leader RNA are critically important in transcription attenuation-mediated control of leucine operon expression in bacteria. The leader RNA contains translational start and stop signals, a cluster of four leucine codons and overlapping regions of dyad symmetry that are capable of forming stem-and-loop structures [1].	25.00	25.00	26.30	26.30	22.60	19.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.92	0.72	-7.16	0.72	-4.27	4	72	2009-01-15 18:05:59	2005-01-11 14:02:44	6	1	72	0	7	20	0	27.80	79	95.61	CHANGED	MhHhsRhhu.LLLNA.llRGh.VuG.Qp	.....MoHIVRFlGLLLLNASpLRGRhVuGIQH...	0	2	3	6
+7887	PF08055	Trp_leader1		Tryptophan leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tryptophan (trp) leader peptides. Tryptophan accumulation is the principal event resulting in downregulation of transcription of the structural genes of the trp operon. The leader peptide of the trp operon forms mutually exclusive secondary structures that would either result in the termination of transcription of the trp operon when tryptophan is in plentiful supply or vice versa [1].	25.00	25.00	48.60	48.50	16.40	14.90	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.54	0.72	-6.78	0.72	-4.36	2	2	2009-01-15 18:05:59	2005-01-11 14:03:54	6	1	2	0	0	2	0	18.00	78	100.00	CHANGED	MFA.phpNWWWTAHPAAH	MFA.phpNWWWTAHPAAH	0	0	0	0
+7888	PF08056	Trp_leader2		Tryptophan operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tryptophan operon  leader peptides. The tryptophan operon is regulated  by transcription attenuation in response to changes  in the level of tryptophan. The transcript of the  leader peptide can adopt alternative mutually-exclusive  secondary structures that would either result in  termination of transcription of the tryptophan structural  genes or in transcription of the entire operon [1].	21.00	21.00	27.00	59.20	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.34	0.72	-3.96	4	77	2009-01-15 18:05:59	2005-01-11 14:04:29	6	1	75	0	5	24	0	37.70	82	87.76	CHANGED	MLQEFNpNpKsKlu.h.p.ssuAELAWWRTWTSSWWANVYF	MLQEFNPNHKPNFS.........PADA....ELAWWRTWTSSWWAHVYF	0	1	1	3
+7889	PF08057	Ery_res_leader2		Erythromycin resistance leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of erythromycin resistance gene leader peptides.  These leader peptides are involved in the transcriptional attenuation control of the synthesis of the macrolide-lincosamide -streptogramin B resistance protein. It acts as a transcriptional attenuator, in contrast to other inducible erm genes. The mRNA leader sequence can fold in either of two mutually exclusive conformations, one of which is postulated to form in the absence of induction, and to contain two rho factor-independent terminators. [1].	25.00	25.00	42.70	42.70	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.07	0.73	-6.10	0.73	-3.49	2	2	2009-01-15 18:05:59	2005-01-11 14:05:10	6	1	2	0	0	1	0	14.00	100	100.00	CHANGED	MTHSMRLRFPTLNQ	MTHSMRLRFPTLNQ	0	0	0	0
+7890	PF08058	NPCC		Nuclear pore complex component	Wood V, Mistry J, Novatchkova M	anon	manual	Domain	Proteins containing this domain are components of the  nuclear pore complex [1].  One member of this family  is Nucleoporin POM34 (Swiss: Q12445) which is thought to have a role in  anchoring peripheral Nups into the pore and mediating pore formation [1].	26.80	26.80	58.40	28.40	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.75	0.71	-4.33	21	117	2009-01-15 18:05:59	2005-01-11 15:00:35	6	5	109	0	89	110	0	130.40	31	39.27	CHANGED	GsWcpPhlcElsRRQ...s.p-ppl++llhNshuhlhh.lhsphlp.hh.hhphspth.s..........................................asphhhhllphlhllNIllALasLh+s..pDshuDlPLTspQRcLLGLsss............spTsush.....hlTPP+Yph	..............................GsWcpPhLcEls+Rp...s.p..Eppl++lhhNshslhhh.hhtphhp.hh.hhththph..s..........................................asshlhhllpllhhlNIlhuLh....Lh+...pDchuDlPLTspQRpLLGLcss.st..................ssssssh.....h.p.P+Yp..............................	0	14	44	75
+7891	PF08059	SEP		SEP domain	Mistry J, Wood V	anon	Pfam-B_1894 (release 16.0)	Domain	The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47.  In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L [1].  Most SEP domains are succeeded closely by a UBX domain [1].	21.50	21.50	21.70	21.70	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.27	0.72	-3.67	44	608	2009-01-15 18:05:59	2005-01-11 17:43:31	8	13	300	3	378	595	4	72.10	36	19.95	CHANGED	lphWpsGFol-DG.LRpacDPtNtpFLpslpcGcsPh-Lhsht.t.ppVsVslpc+pcEcYhtPhh..phpsFsGpGp	.......lplWcsG.Fol.s.D.Gs....LRsas...DP..s....N.tpFLc.......s.....I.p..cG........chPhELtp.h.....h.t....ppVslclpc+psEsahps.......thpsFsGpGp...................	0	118	184	273
+7892	PF08060	NOSIC		NOSIC (NUC001) domain	Staub E, Bateman A	anon	Staub E	Domain	This is the central domain in Nop56/SIK1-like proteins [1].	23.70	23.70	24.10	23.70	22.80	23.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.55	0.72	-4.16	101	1203	2009-09-11 13:22:58	2005-01-12 13:32:34	8	20	441	26	811	1191	39	52.30	44	10.32	CHANGED	hIlQulsll-clD+-lNhhthRlREWYuh+FPELspllsc.shpYu.+lVthlGs	........hIlQAluLLDpLDK-lNsasMRlREWYuaHFPELs+lls....D....shpYs.+llphlGp..............	0	287	457	669
+7893	PF08061	P68HR		P68HR (NUC004) repeat	Staub E, Bateman A	anon	Staub E	Repeat	This short region is found in two copies in p68-like RNA helicases [1].	25.00	25.00	30.50	33.30	23.60	24.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.31	0.72	-4.22	8	120	2009-01-15 18:05:59	2005-01-12 13:38:59	6	6	32	0	40	103	0	33.60	59	11.58	CHANGED	SAGhpuGFpohpsptsYppGYuu..pppaGupspN	..SAGhpsuFpT.hpsptsYppGYsS..pppaGupstN.	0	2	2	12
+7894	PF08062	P120R		P120R (NUC006) repeat	Staub E, Bateman A	anon	Staub E	Repeat	This characteristic repeat of proliferating cell nuclear antigen P120 is found in three copies [1].	20.30	20.30	21.70	20.30	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.62	0.73	-6.89	0.73	-3.37	6	44	2009-01-15 18:05:59	2005-01-12 13:43:13	6	5	10	0	8	55	0	21.90	49	6.15	CHANGED	sGKA+GspKsK.QQLh+Q.tsKt	.hGKAKGlcKsK.pph.KQ.tsKh.....	0	3	3	3
+7895	PF08063	PADR1		PADR1 (NUC008) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found in poly(ADP-ribose)-synthetases [1]. The function of this domain is unknown.	21.10	21.10	21.10	23.00	21.00	19.10	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.12	0.72	-4.57	17	187	2009-01-15 18:05:59	2005-01-12 14:18:02	7	27	111	4	131	208	2	54.70	41	6.18	CHANGED	ll-RluDshhFGsLt.CspCsG.phhapup..tYhCpG.l..StWoKC..sapspsPpRhp	.........ll-RlADshhFGALhsCsp..Csu.....pl..hapus..sYhCoGpl...otWoK.C..shpTpsPsRp...........	0	54	72	108
+7896	PF08064	UME		UME (NUC010) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 [1].	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.06	0.72	-4.09	29	246	2009-01-15 18:05:59	2005-01-12 14:25:06	8	14	218	0	176	262	1	105.80	24	4.49	CHANGED	lspaLppchLGllshFspslpc...sppshh-KccslpuIt.ll+.hstpplssshsQ......IhssLpouLchp...-LpptuhpsWplhlppLsp...pcltsllsphlshllphasp	...............hspaLpp+lLGllshFsppltc.....s.p.....tsh.-K+pslpultpll+.h.............ss.........pplssshsp.................lhssLpou.Lphc..........-lpph...s..hpsWsshlpsLsp...pcLtsllspslshll.hhp.h..............................	0	51	92	143
+7897	PF08065	K167R		K167R (NUC007) repeat	Staub E, Bateman A	anon	Staub E	Repeat	This family represents the K167/Chmadrin repeat [1]. The function of this repeat is unknown.	20.70	20.70	21.10	20.70	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.28	0.71	-3.97	24	437	2009-01-15 18:05:59	2005-01-12 14:29:07	7	18	30	0	146	511	0	104.90	42	46.71	CHANGED	sTKlsscSPQP-sscTssSoKppsKpuLpKs-V+EEh.AlpKhopouGcshcT.+.ssu-s+sIcuhhposKQKLDssusloGSKRp.pTPKE+AQsLEDLsG.FpELFQTPu	.......................TKhsC+Ss.s-slsTPsSp+p.......p.+pslt..Ks-lcEE.h.Al.p..KhTposGcsscT..+.....Ps.u-c+slcsa.....pcoP+QKL.Dsstsl.oGSKR...psRTP.K-K.A.Q.......sLEDLsG.FKELFQTP........	1	16	18	28
+7898	PF08066	PMC2NT		PMC2NT (NUC016) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found at the N-terminus of 3'-5' exonucleases with HRDC domains, and also in putative exosome components [1].	22.20	22.20	22.50	22.50	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.82	0.72	-3.69	31	282	2009-01-15 18:05:59	2005-01-12 14:35:30	7	8	228	0	176	278	0	91.50	28	11.48	CHANGED	llsss+uuuuLuu..pDlsFY+ohpsshuppl-ppupcLLslhspllp.thsspschhtss.......t.csl-s..pacsls-shDsLhE+sDpsLDchsGh	.............llsss+uu.suLsp....c-...hsFa+Sh.Psap...p.h-ppusRLLphhsp.lhp.htssp..s.shpsts...........................p.spl--..pa.c.h.ll-s.DslLE+sshhLDEhsG.l................	0	54	90	143
+7899	PF08067	ROKNT		ROKNT (NUC014) domain	Staub E, Bateman A	anon	Staub E	Domain	This presumed domain is found at the N-terminus of RNP K-like proteins that also contains KH domains Pfam:PF00013 [1].	19.90	19.90	23.40	22.80	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.13	0.72	-4.10	4	131	2009-01-15 18:05:59	2005-01-12 14:39:44	6	8	36	0	42	81	0	42.40	79	10.24	CHANGED	M-TE.-.Q.EEsoFSNsEoNGKRPAEDh-EEpuFKRSRNoDEMV	...........METE...Q.sEETFsNTETN...Gc..hGK...RPAEDME.EEQAFKRSRNTDEMV..	0	1	6	15
+7900	PF08068	DKCLD		DKCLD (NUC011) domain	Staub E, Bateman A	anon	Staub E	Domain	This is a TruB_N/PUA domain associated N-terminal domain of Dyskerin-like proteins [1].	20.90	20.90	20.90	20.90	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.76	0.72	-4.04	16	540	2009-01-15 18:05:59	2005-01-12 14:44:23	7	12	459	21	349	531	82	54.30	55	12.61	CHANGED	csupaPLLLKshc.+LhVRos.caTPhshGssPhcRsIcEYlchGlINLDKPusPSSHEVV	................sSpWPLLLKNa-.c.............L.VRos.HaTPl.stGssPL+RslppYlp.pGlINLDKPuNPSSHEVV........	0	117	200	290
+7901	PF08069	Ribosomal_S13_N		Ribosomal S13/S15 N-terminal domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found at the N-terminus of ribosomal S13 and S15 proteins.\	     This domain is also identified as NUC021 [1].	25.00	25.00	27.60	26.50	22.80	21.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.85	0.72	-4.13	64	646	2009-01-15 18:05:59	2005-01-12 14:52:27	7	7	524	8	365	560	71	58.50	55	38.20	CHANGED	MuRMHu+t..+..GhSuSshPh....+ppsPpWlp..hos-ElcchIlcLAK.+GhsPSpIGllLRDpaGI	.........................MGRMHutG..K..GlSpSAlPY....+RssP....sWlK..hos--Vc-pIhKLAK.KGhTPSQIGVlLRDuHGl...	0	115	203	297
+7902	PF08070	DTHCT		DTHCT (NUC029) region	Staub E, Bateman A	anon	Staub E	Family	The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins [1]. This region is composed of quite low complexity sequence.	19.70	19.70	20.50	20.40	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.39	0.72	-3.34	8	130	2009-09-10 16:42:44	2005-01-12 14:58:57	6	9	47	0	61	99	0	96.90	43	6.92	CHANGED	+AAPKusKp.......DS-hsuulsKKPsPsKuKs...p+KRKsSSSD-SDSsFtKtsSKusTSKKuK.......u-sDDFpsDhs....sss...APRs+SGRAKKPlKYLE	........................+tAPK.tpKh..........D.S-t.phu.l.sKKss.s..s...K.uKs......................++++tsuSps.-..uD.s.......t....+tsSK.....sssSKKsKp.............u-sDpF..s.Dhs.....ops.......ss+s+oGR..A.+K.lKYht............	1	6	9	25
+7903	PF08071	RS4NT		RS4NT (NUC023) domain	Staub E, Bateman A	anon	Staub E	Domain	This is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].	20.40	20.40	20.60	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-7.69	0.72	-4.10	34	754	2009-01-15 18:05:59	2005-01-12 15:00:55	7	10	531	4	419	697	74	36.40	62	14.46	CHANGED	pGs+KHLKRlsAPppWhls+ps.utaAs+PSsGPHphcc	.....RGsKKHLKRLsAP++.WMLDKLs.GsaAPRPSsGPHKLRE.....	0	139	234	326
+7904	PF08072	BDHCT		BDHCT (NUC031) domain	Staub E, Bateman A	anon	Staub E	Domain	This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily [1].	25.00	25.00	41.50	40.30	18.10	16.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.06	0.72	-3.85	3	59	2009-01-15 18:05:59	2005-01-12 15:04:31	6	7	34	0	22	45	0	40.30	67	3.39	CHANGED	QLlSVME-ICKLVDsIPlcEL+lLSCGpELLQQRplRRKLL	.QLl+VMEcICKLVDTIPtDcLKsLcCGsELLQQRslRRKLL....	0	1	3	7
+7905	PF08073	CHDNT		CHDNT (NUC034) domain	Staub E, Bateman A	anon	Staub E	Domain	The CHDNT domain is found in PHD/RING finger and chromo domain-associated helicases [1].	20.80	20.80	21.00	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.54	0.72	-4.28	5	268	2012-10-02 14:16:02	2005-01-13 16:21:08	7	31	81	0	123	210	1	54.50	69	3.24	CHANGED	V-l-YoEEDacoLTNYKAFSpaVRPlIsKcNPKIssoKMMMLluAKWREFsssNP	...........l-alFSEEDY+TLTNYKAFSQFl..RPLIA.+KNPKIshSKMMhl......LGAKWREFSsNNP..........	0	20	32	70
+7906	PF08074	CHDCT2		CHDCT2 (NUC038) domain	Staub E, Bateman A	anon	Staub E	Domain	The CHDCT2 C-terminal domain is found in PHD/RING finger and chromo domain-associated CHD-like helicases [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.08	0.71	-4.53	4	307	2009-01-15 18:05:59	2005-01-13 16:28:26	6	33	89	0	132	242	0	160.40	78	10.29	CHANGED	KhsEIWHRRHDaWLLAGlslHGYARWQ....DItNDspFAIlNEPFKspusc..sNFLEhKNKFLARRFKLLEQALVIEEQLRRAAaLNhpQ-PsHPAMALsARFAElECLAESHQHLSKEShsGN+sANAlLHKVLsQL--LLuDhKsDVsRLPuTlSpltP..VssRLtMSERpILSpL	........................Kh.EIWHRRHDYWLLAGIlp........HGYAR....WQ.................DIQNDsRaAIlNEPF.........KsEhsK.........GNFLEhKNKFLARRF.K..L..LEQALVIEEQLRRAAYLN.hop.DPuH...P...uMALNsRFAEV...ECLAESHQHLSK.EShA.GNKPANAVL.HK....VLsQLEELLSDMKADVTRLPATLuRIPP..VAsRLQMSERsILSRL...................	0	26	37	75
+7907	PF08075	NOPS		NOPS (NUC059) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found at the C-terminus of NONA and PSP1 proteins  adjacent to 1 or 2 Pfam:PF00076 domains [1].	20.20	20.20	20.30	24.50	19.90	18.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.50	0.72	-3.56	11	282	2009-01-15 18:05:59	2005-01-13 16:34:28	6	8	89	2	146	244	1	51.10	64	10.43	CHANGED	PllVEPhEp.DDpDGLPEK.LspKsspapKEREpsPRFAp.GoFEaEYusRWK	.....PVlVEPhEQhDDE.DGLPEK.LspKs.pap...KEREpPPRFAQPGoFEaEYupRWK....	0	27	36	78
+7908	PF08076	TetM_leader		Tetracycline resistance determinant leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tetracycline resistance  determinant tet(M) leader peptides. A short open  reading frame corresponding to a 28 amino acid peptide  which contain a number of inverted repeat sequences was  found immediately upstream of the tet(M). Transcriptional  analyses has found that expression of tet(M) resulted from an  extension of a small transcript representing the upstream  leader region into the resistance determinant. Thus this  leader sequence is responsible for transcriptional attenuation  and thus regulation of the transcription of tet(M) [1].	25.00	25.00	60.40	60.10	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.26	0.72	-4.39	3	31	2009-01-15 18:05:59	2005-01-14 11:01:15	6	2	28	0	1	8	0	27.70	92	72.55	CHANGED	MLChPMlMH+FPSDKSIYHWDFhuLFGF	MLChPMVMHKNPSDKSIYHWDFYALLGF	0	1	1	1
+7909	PF08077	Cm_res_leader		Chloramphenicol resistance gene leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of chloramphenicol (Cm) resistance  gene leader peptides. Inducible resistance to Cm in both  Gram positive and Gram negative bacteria is controlled  by translation attenuation. In translation attenuation,  the ribosome-binding-site (RBS) for the resistance  determinant is sequestered in a secondary structure domain  within the mRNA. Preceding the secondary structure is a  short, translated ORF termed the leader. Ribosome stalling  in the leader causes the destabilization of the downstream  secondary structure, allowing initiation of translation  of the Cm resistance gene [1].	25.00	25.00	48.90	48.80	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.15	0.73	-6.44	0.73	-3.94	2	3	2009-01-15 18:05:59	2005-01-14 11:02:43	6	1	3	0	1	1	0	17.00	100	100.00	CHANGED	MSGVPGALAVVTRRTIS	MSGVPGALAVVTRRTIS	0	0	0	1
+7910	PF08078	PsaX		PsaX family	Lee SC	anon	Short protein clustering	Family	This family consists of the PsaX family of photosystem I (PSI) protein subunits.\	      PSI is a large multi-subunit pigment protein complex embedded in the thylakoid membranes of green plants and cyanobacteria. PsaX is one of the 12 protein subunits found in PSI and these subunits are arranged as monomers or trimers within the membrane as shown by the structure of the trimeric complex from Synechococcus elongatus [1].	25.00	25.00	33.50	33.00	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.72	0.72	-4.03	2	15	2009-01-15 18:05:59	2005-01-14 11:04:10	7	1	15	2	6	15	0	36.10	63	68.65	CHANGED	SshAspuAKPsYsFRThWAlLLLAlNFLVAAYYFtIl	.........ssKuAKPsYsFRTuWAl.LLLAINFLVAAYYFHII	0	0	5	6
+7911	PF08079	Ribosomal_L30_N		Ribosomal L30 N-terminal domain	Staub E, Bateman A	anon	Staub E	Domain	This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018 [1].	23.90	23.90	24.20	24.90	23.80	23.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.49	0.72	-3.96	70	661	2009-01-15 18:05:59	2005-01-14 14:47:42	7	8	345	8	354	608	5	68.80	34	28.50	CHANGED	olLKKRKpppph+tpptppthtp+ttppp+RphIa+RAEpYhKEY+ptER-.IRLpRpA+ppGsaYVPuEs	................................olLKKRKp.pp.h+tpptppth.t.pKt......tp+tc..Rc.lIacRA.cpYhKEY+..........ptcRcpIRlpR.A+ptGsaYVPuEs...........	0	109	177	256
+7912	PF08080	zf-RNPHF		RNPHF zinc finger	Staub E, Bateman A	anon	Staub E	Domain	This domain is a putative zinc-binding domain (CHHC motif) in RNP H and F.  The domain is often associated with Pfam:PF00076.	20.20	20.20	20.80	21.10	18.00	19.20	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.96	0.72	-4.45	3	163	2009-01-15 18:05:59	2005-01-14 14:50:25	7	9	41	2	72	105	0	33.70	76	8.58	CHANGED	FGSDRFGRDLoYChSGMSDHRYGDGsSTFQSTTGHC	..........FsoD.hFGR.D..LsYChSG...MSD.HRYGDGGSTFQSTTGHC.......	0	4	8	18
+7913	PF08081	RBM1CTR		RBM1CTR (NUC064) family	Staub E, Bateman A	anon	Staub E	Family	This C-terminal region is found in RBM1-like RNA binding hnRNPs [1].	22.00	22.00	22.60	25.80	21.60	18.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.27	0.72	-4.23	8	128	2009-01-15 18:05:59	2005-01-14 14:57:06	6	3	49	0	49	133	0	45.30	69	12.12	CHANGED	SuusMG..GRushSRGRDuYG.GPPRR-shsSRRDsYhuPRDDGYSo+	...............SSSGMG..GRAPlSRGRDuYG.GPP.RREPlPSRRDVYLSPRDDGYSTK......	0	9	11	19
+7914	PF08082	PRO8NT		PRO8NT (NUC069), PrP8 N-terminal domain	Staub E, Bateman A	anon	Staub E	Domain	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].	25.00	25.00	25.00	31.00	21.00	24.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.99	0.71	-4.57	24	428	2009-01-15 18:05:59	2005-01-14 14:59:30	6	30	362	0	242	401	7	136.00	71	7.54	CHANGED	Kt-MPPEHLRKIl+DHGDMSS++apsDKRsaLGALKYlPHAlhKLLENMPhPWEps+pVKVLYHhoGAITFVNElP+VIEPlYhAQWuTMWlhMRREK....RDR+HFKRMRFPPFDDEEPPLDYu-Nl.DlEP.-uIphcLDpp-DssVhDWhYD	.....................................Kt-MPPEHlRKIl+................DhGDhop+KappDKRsYLG...ALKahPHAlhKLLENMPMPWE.plR-VcVLYHITGAITFVNEIPhVIEPVYlAQWGoMWIMMRREK....RDRRHFKRMRFPPFDDEEPPLDYuD.NlLDVEPLEsIQh.ELDp-EDss.Vh-WFYD................................	0	94	143	205
+7915	PF08083	PROCN		PROCN (NUC071) domain	Staub E, Bateman A	anon	Staub E	Domain	The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family [1].	19.80	19.80	19.80	19.90	19.70	18.90	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.45	0.70	-6.00	12	433	2009-01-15 18:05:59	2005-01-14 15:01:09	6	40	348	0	269	361	13	328.20	62	18.09	CHANGED	LhscpTpsuh...tLhaAPhPFN++pGt......h+RAtDlsLlKpWapp+ss...sshPsKV+VSYQKLLKsaVhNpL+p.......pc.psppK............hpLL+sLKsTKFFQpTpIDWVEAGLQlCRQGaNMLNLLIHRKsLsYLHLDYNFNLKPsKTLTTKERKKSRFGNAFHLhREIL+hhKllVDuHVQaRLGNlDAaQLADGltYIhsHlGQLTGlYRYKYKlM+QIRtCKDLKHll.YhRFNs..lGKGPGCGFWtPuWRVWlFFLRGIIPLLERWLGNLLsRQFEGRpSpsl..sKTlTKQRl-SaaDLELRAuVMpDILDMlP-Gl+..psKuRTILQHLSEAWRCWKANlPWcVPGhPtPlcsIIhRYlKuKADhWhssAaYNR-RI+RGAsV-KTlsKKNLGRLTRLWlKsEQERQ+phhK..-GPhl	.....................................................sppTssuI...sLhaAPhPFshRSG+......hhRA.D.....lPLlppWY..h.EHsP....s.PVKVRVSYQKLLKhaVLNtL+p.......+..PK...s.p.pK....................p.Lh+shKsT.KFFQpTplDWVEsGLQVCRQGaNMLNL.LIHRKsLsYLHLDYNFNLKPlKTLTTKERKKSRFGNAFHLhRE.lLRLoKLlVDupVQaRLGNlDAaQLADGl.YhFs...HVGQLTGMYRYKY+LM+QIRhCKDLKHlI.YYRFNoGsVGKGPGCGFWAPuWRVWlFFhRGIhPLLERWLGNLLuRQF..E..GRcSKGl..AKTVTKQRVESHaDLELRAuVM+DllDMMP.E.GlK..................QNKsRTILQHLSEAWRCW.........KANIPWK...............VP..GLPhPIENhILRYVKtKADWWhssAHYNRERI+RGATVDKTVsKKNLGRLTRLaLKuEQERQ+sYhK..DGPYl.............................	0	108	159	227
+7916	PF08084	PROCT		PROCT (NUC072) domain	Staub E, Bateman A	anon	Staub E	Domain	The PROCT domain is the C-terminal domain in pre-mRNA splicing factors of PRO8 family [1].	19.50	19.50	19.70	20.00	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.76	0.71	-4.42	32	394	2009-01-15 18:05:59	2005-01-14 15:02:50	6	37	344	4	235	386	4	107.70	55	5.71	CHANGED	slslolSFoPGSsolsAapLTppGapWGt...pNpDhhsppPpGapssahc+sQlLLSD+hhGaFhVPcsslWNYsFhGspas...shpYslpl-hPhsFYc-lHRPtHFlpFscl....tts-.phpsD.-ssF	.......................TlhlTsSFTPGSsSLoAY+LTPsGYEWG+...pNpD........t.u..sp..Pp......Ga..s.o..hhE+sQhLLSD+hhGaFhVPp.pss.WNYsF.M..Gspas....phpaplpls.sPhpFYc-.HRP.HFhpFupl.........-...h.sDppD.............................	2	85	132	194
+7917	PF08085	Entericidin		Entericidin EcnA/B family	Lee SC	anon	Short protein clustering	Family	This family consists of the entericidin antidote/toxin peptides. The entericidin locus is activated in stationary phase under high osmolarity conditions by rho-S and simultaneously repressed by the osmoregulatory EnvZ/OmpR signal transduction pathway. The entericidin locus encodes tandem paralogous genes (ecnAB) and directs the synthesis of two small cell-envelope lipoproteins which can maintain plasmids in bacterial population by means of post-segregational killing [1].	23.30	23.30	23.30	23.30	23.20	23.10	hmmbuild  --amino -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.26	0.73	-6.22	0.73	-4.02	64	1429	2012-10-01 23:27:00	2005-01-14 17:10:06	6	3	892	0	211	521	26	21.00	57	43.49	CHANGED	NTspGsGcDlpsuGpAlpcuA	.NTsRGhGEDIpcuGsAISpAA.....	0	33	99	154
+7918	PF08086	Toxin_17		Ergtoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of ergtoxin peptides which are toxins secreted by the scorpions.\	 The ergtoxins are capable of blocking the function of K+ channels. More than 100 ergtoxins have been found from scorpion venoms and they have been classified into three subfamilies according to their primary structures [1].	25.00	25.00	83.10	83.00	23.30	21.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.46	0.72	-3.89	4	27	2012-10-01 23:31:40	2005-01-14 17:11:46	6	1	6	2	0	27	0	41.00	79	93.81	CHANGED	DRDSCVDKS+CuKYGYYtQCp-CCKKAGHsGGTChYFKCKC	.DRDSCVDKS+CuKYGYYtQCp-CCKKAGcpuGTChaFKCKC	0	0	0	0
+7919	PF08087	Toxin_18		Conotoxin O-superfamily	Lee SC	anon	Short protein clustering	Domain	This family consists of members of the conotoxin  O-superfamily. The O-superfamily of conotoxins  consists of 3 groups of Conus peptides that belong  to the same structural group. These 3 groups differ  in their pharmacological properties: the w-conotoxins  which inhibit calcium channels, the delta-conotoxins  which slow down the inactivation rate of voltage -sensitive sodium channels and the muO-conotoxins block  the voltage sensitive sodium currents [1].	24.30	24.30	26.10	26.10	22.10	21.30	hmmbuild  --amino -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.62	0.72	-4.17	7	30	2012-10-01 22:06:18	2005-01-14 17:12:28	6	1	24	0	0	32	0	31.10	72	56.38	CHANGED	hACsETGtsChaS.ECCS..GACSssFsaCL.p	.hACTETGRNCpaS.ECCS..GACSAsFsaCL.R....	0	0	0	0
+7920	PF08088	Toxin_19		Conotoxin I-superfamily	Lee SC	anon	Short protein clustering	Family	This family consists of the I-superfamily of  conotoxins. This is a new class of peptides in  the venom of some Conus species. These toxins  are characterised by four disulfide bridges and  inhibit of modify ion channels of nerve cells.  The I-superfamily conotoxins is found in five or  six major clades of cone snails and could possible  be found in many more species [1].	23.20	23.20	23.70	23.40	22.30	23.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.93	0.72	-4.05	8	26	2009-01-15 18:05:59	2005-01-14 17:13:11	7	1	5	3	0	29	0	40.30	66	83.17	CHANGED	G.s.CtpDt+sCsYHADCCN..CChtGhCpPSTsWI..GCSTus	...G.s.CtKDt+tCsYHADCCN..CCLo..GICtPSTsWI..GCSTu...	0	0	0	0
+7921	PF08089	Toxin_20		Huwentoxin-II family	Lee SC	anon	Short protein clustering	Family	This family consists of the huwentoxin-II (HWTX-II)  family of toxins secreted by spiders. These toxins are found in venom that secreted from the bird spider  Selenocosmia huwena Wang. The HWTX-II adopts a novel  scaffold different from the ICK motif that is found in  other huwentoxins. HWTX-II consists of 37 amino acids  residues including six cysteines involved in three  disulfide bridges [1].	25.00	25.00	31.80	51.80	21.20	19.70	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.41	0.72	-4.06	3	92	2009-01-15 18:05:59	2005-01-14 17:13:28	6	1	10	2	0	90	0	38.40	81	47.52	CHANGED	lFECoFSCDIEKEG.KPCKPKG..........+KKCSGGWKCKlKLCLKl	.LFECSlSCEIEKEG.....NKsCK.............KKKC..KGGWKCKFNMCVKV.	0	0	0	0
+7922	PF08090	Enterotoxin_HS1	Enterotoxin_ST; 	Heat stable E.coli enterotoxin 1	Lee SC	anon	Short protein clustering	Family	Heat-stable toxin 1 of entero-aggregative E.coli (EAST1) is a small toxin. It is not, however, solely associated with entero-aggregative E.coli but also with many other diarrhoaeic E. coli families. Some studies have established the role of EAST1 in some human outbreaks of diarrhoea. Isolates from farm animals have been shown to carry the astA gene coding for EAST1. However, the relation between the presence of EAST1 and disease is not conclusive [1].	25.00	25.00	73.10	73.10	19.70	17.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.93	0.72	-4.20	2	9	2009-01-15 18:05:59	2005-01-14 17:14:06	6	1	4	0	0	8	0	35.30	91	96.07	CHANGED	ShphIR+PASShASCIWCsTACuSs.GRTTKPS.AT	STQYIRRPASSYASCIWCATACASCHGRTTKPSLAT	0	0	0	0
+7923	PF08091	Toxin_21		Spider insecticidal peptide	Lee SC	anon	Short protein clustering	Domain	This family consists of insecticidal peptides isolated  from venom of spiders of Aptostichus schlingeri and  Calisoga sp. Nine insecticidal peptides were isolated  from the venom of the Aptostichus schlingeri spider and  seven of these toxins cause flaccid paralysis to insect  larvae within 10 min of injection. However, all nine  peptides were lethal within 24 hours [1].	20.10	20.10	20.20	22.50	19.80	19.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.54	0.72	-4.25	2	5	2012-10-01 22:06:18	2005-01-14 17:14:47	6	1	3	0	0	5	0	38.20	57	69.96	CHANGED	C.StthPCoNuc-CCuGpCuh.hWsCh..tssCSKpC.u.	CISARYPCSNSKDCCSGNCGs.FWTCalRKDPCSKECLAP.	2	0	0	0
+7924	PF08092	Toxin_22		Magi peptide toxin family 	Lee SC	anon	Short protein clustering	Family	This family consists of Magi peptide toxins (Magi 1, 2 and 5) isolated from the venom of Hexathelidae spider. These insecticidal peptide toxins bind to sodium channels and induce flaccid paralysis when injected into lepidopteran larvae. However, these peptides are not toxic to mice when injected intracranially at 20 pmol/g [1].	25.00	25.00	26.30	26.10	24.60	18.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.41	0.72	-4.12	3	78	2012-10-01 22:06:18	2005-01-14 17:15:22	6	1	8	0	0	79	0	39.20	84	36.06	CHANGED	CMGYDIECNEcLP.CCua..LECV+TSGY.WWYK+pYCRRK+	....CIGEGVPC.D....ENDP.RCCSG..LVCLKPTLHGIWYKSYYCYKK....	0	0	0	0
+7925	PF08093	Toxin_23		Magi 5 toxic peptide family	Lee SC	anon	Short protein clustering	Family	This family consists of toxic peptides (Magi 5) found in the venom of the Hexathelidae spider. Magi 5 is the first spider toxin with binding affinity to site 4 of a mammalian sodium channel and the toxin has an insecticidal effect on larvae, causing paralysis when injected into the larvae [1].	19.60	19.60	20.20	49.90	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.85	0.72	-4.01	5	8	2012-10-01 22:06:18	2005-01-14 17:16:09	6	1	5	3	0	9	0	29.20	50	36.68	CHANGED	uClLoph+CSSDK-CCGhTPsCshGlClPs	sClLophtCSsDK-CCGhTPsCshGlCsPp	0	0	0	0
+7926	PF08094	Toxin_24		Conotoxin TVIIA/GS family	Lee SC	anon	Short protein clustering	Family	This family consists of conotoxins isolated from the venom  of cone snail Conus tulipa and Conus geographus. Conotoxin  TVIIA, isolated from Conus tulipa displays little sequence  homology with other well-characterised pharmacological  classes of peptides, but displays similarity with conotoxin GS, a peptide from Conus geographus. Both these peptides  block skeletal muscle sodium channels and also share  several biochemical features and represent a distinct subgroup  of the four-loop conotoxins [1].	25.00	25.00	71.00	71.00	17.80	17.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-7.96	0.72	-4.35	2	2	2012-10-01 22:06:18	2005-01-14 17:16:32	6	1	2	2	0	4	0	31.50	63	98.44	CHANGED	uCSGRsSRCPP.CCMGLhCuRG...KCluhat-	uCSGRsSRCPP.CCMGLhCuRG...KCluhat-	0	0	0	0
+7927	PF08095	Toxin_25		Hefutoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of the hefutoxins that are found  in the venom of the scorpion Heterometrus fulvipes.  These toxins, kappa-hefutoxin1 and kappa-hefutoxin2,  exhibit no homology to any known toxins. The hefutoxins  are potassium channel toxins [1].	25.00	25.00	28.30	27.60	17.70	16.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.65	0.72	-6.82	0.72	-4.19	2	4	2009-01-15 18:05:59	2005-01-14 17:17:22	6	1	3	1	0	4	0	22.00	67	67.69	CHANGED	GHACYRNCWREGNDEETCKERC	GauCYRsCW+tGpDEETCKccC	0	0	0	0
+7928	PF08096	Bombolitin		Bombolitin family	Lee SC	anon	Short protein clustering	Family	This family consists of the bombolitin peptides that  are found in the venom of the bumblebee Megabombus  pennsylvanicus. Bombolitins are structurally and  functionally very similar. They lyse erythrocytes and  liposomes, release histamine from rat peritoneal mast  cells, and stimulate phospholipase A2 from different  sources [1].	25.00	25.00	26.50	26.50	17.30	16.10	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.39	0.74	-6.37	0.74	-3.51	2	4	2009-09-11 05:23:05	2005-01-14 17:17:58	6	1	1	0	0	4	0	17.00	77	100.00	CHANGED	.KIhDILAKLGKVLAHV	IKIpDILAKLGKVLAHV	0	0	0	0
+7929	PF08097	Toxin_26		Conotoxin T-superfamily	Lee SC	anon	Short protein clustering	Family	This family consists of the T-superfamily of conotoxins.  Eight different T-superfamily peptides from five Conus species were identified. These peptides share a consensus signal sequence, and a conserved arrangement of cysteine residues. T-superfamily peptides were found expressed in venom ducts of all major feeding types of Conus, suggesting that the T-superfamily is a large and diverse group of peptides, widely distributed in the 500 different Conus species [1].	25.00	25.00	27.80	27.80	12.90	11.70	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.18	0.73	-6.36	0.73	-3.17	2	2	2009-01-15 18:05:59	2005-01-14 17:18:32	6	1	1	0	0	2	0	11.00	91	100.00	CHANGED	FCCPhIRYCCW	FCCPhIRYCCW	0	0	0	0
+7930	PF08098	ATX_III		Anemonia sulcata toxin III family	Lee SC	anon	Short protein clustering	Family	This family consists of the Anemonia sulcata toxin III  (ATX III) neurotoxin family. ATX III is a neurotoxin  that is produced by sea anemone; it adopts a compact  structure containing four reverse turns and two other  chain reversals, but no regular alpha-helix or beta-sheet.  A hydrophobic patch found on the surface of the peptide may  constitute part of the sodium channel binding surface [1].	25.00	25.00	25.60	25.20	17.90	16.00	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.61	0.72	-4.12	2	7	2009-01-15 18:05:59	2005-01-14 17:18:57	6	1	3	1	0	7	0	24.30	76	41.98	CHANGED	poCCPC....YhuGCPWGQssa.pGCS	KSCCPC...hhpGs.CFWGQNCYPEGCS	0	0	0	0
+7931	PF08099	Toxin_27		Scorpion calcine family	Lee SC	anon	Short protein clustering	Family	This family consists of the calcine family of scorpion  toxins. The calcine family consists of Maurocalcine and  Imperatoxin. These toxins have been shown to be potent  effector of ryanodyne-sensitive calcium channel from  skeletal muscles. These toxins are thus useful for  dihydropyridine receptor/ryanodyne receptor interaction  studies [1,2].	25.00	25.00	55.50	55.10	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-7.87	0.72	-4.05	2	5	2012-10-01 22:06:18	2005-01-14 17:20:37	6	1	4	1	0	5	0	33.00	83	60.66	CHANGED	GDCLPHLKhCKtspDCCuKKCKRRGTNhEKRCR	.GDCLPHLKRCKENNDCCSKKCKRRGTNPEKRCR	0	0	0	0
+7932	PF08100	Dimerisation		Dimerisation domain	Bateman A	anon	Pfam-B_455 (Release 16.0)	Domain	This domain is found at the N-terminus of a variety of plant O-methyltransferases. It has been shown to mediate dimerisation of these proteins [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.30	0.72	-4.13	30	919	2012-10-04 14:01:12	2005-01-16 14:21:20	6	7	155	29	350	965	0	50.20	38	14.45	CHANGED	MsLKsAlELGlh-lltptG........phlosSElsupLs....hsPcusshlDRlLRlLu	...........MsLKsAl-LGls-hIpptG...........tshoh.s-ls.u...pLs..........hpPs...p.s...s..h.lcR.lhRlLs...........	0	22	202	291
+7933	PF08101	DUF1708		Domain of unknown function (DUF1708)	Mistry J, Wood V, Novatchkova M	anon	manual	Domain	This is a yeast domain of unknown function.	20.80	20.80	20.90	21.60	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.55	0.70	-5.64	19	144	2012-10-03 21:54:49	2005-01-24 15:49:59	6	4	126	0	112	156	0	412.60	32	37.80	CHANGED	pphstccV+pllHhhTtELKsRGhchsalhLPFRPcpssppl.sFlpphFshustt...hptctl.phlpps-shTLhpsLKah..WsRLPsu.lluW-sYppFKhtEp-psa.s+cAFlplhPpslsSsuHusIlYDFhDLLsuIuup....uphNthuGRKl.S+MuuhWAFs.spt.s...................su...FpsGhcpWtpuu-AhhHLhlAaLRShsPcs.pss....+LPpoLpsLL.sspYPPp.psshhpscoh.....pVPhlshps...SpsPapLLcRssc....st.t.Fps+-sashLpshF..phcssh...l.ptLocES+RlLcplo....osp........................................................................pshpsuWuc...................................................pphh...pscsshp.tpthSlscl-lcDaFhWsWhSSLusEpssp+KplFGRshllEscl...sG.pKWlVhpEps	...........................................................................p.pht.cclppll+hhTtELKt...Ru..h.................chPalh....LP..F....RPp......pssst....hcsFlpphF...ststtt..........ps.......ctl..p.c.l....p.h.s-sh...sLssslKah..Wu..RL.................P..........s.....G....l........lsW..-..u.....YphF..+htE....................p...................-upa.s+cAFt.shlPhslsS.su+.spIlaDFFDLlsulAA+.....u+tNuhuGRKL.S+hsuhWAFppscss.........................su...FpsuacsWhpAuDAhpHLhhAaLRS.....hsPcs.tss......pLPhoLpsLlptspY...........P........Pp.psshhpspoh...............pVsh.ls....ss...SssPatLLcRspp.........FphR-s.thLpph....phcssh.....pthocEs+RlLcslo....stp.................................................................................................................................................................................................pshsPuWAc...................................................................................p.th.....-pth.p.tp.h.sslsph-lDD.FhWsWhSSLusEpsst+KthFGRshllEs.l....u.t+WllhpE...................................................................................................................................................................................................................................................................................................................................................	0	32	63	99
+7934	PF08102	Antimicrobial_7		Scorpion antimicrobial peptide 	Lee SC	anon	Short protein clustering	Family	This family consists of antimicrobial peptides secreted by scorpions. Novel antimicrobial peptides have been isolated from scorpions, namely the opistoporin [1] and the pandinin [2]. These peptides form essentially helical structures and demonstrate high antimicrobial activity against Gram-negative and Gram-positive bacteria respectively.	25.00	25.00	27.30	46.10	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-7.94	0.72	-3.94	4	7	2009-01-15 18:05:59	2005-01-25 14:26:24	6	1	5	0	0	8	0	42.00	60	67.59	CHANGED	GKVWDWIKSsAKKlWNS-sVppLKspuLNAAKNaVAEKIGATP	.G.lWDhIKshAKKlWNS-ssppLKspALNAAKNaVAEKIGATP	0	0	0	0
+7935	PF08103	Antimicrobial_8		Uperin family	Lee SC	anon	Short protein clustering	Family	This family consists of the uperin family of antimicrobial peptides.  Uperin is a wide-spectrum antibiotic peptide isolated from the Australian toadlet, Uperoleia mjobergii. Being only 17 amino acid residues long, it is smaller than most other wide-spectrum antibiotic peptides isolated from amphibians. Uperin adopts a well-defined amphipathic alpha-helix with distinct hydrophilic and hydrophobic faces [1].	21.40	21.40	24.10	32.00	20.60	16.60	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.13	0.73	-6.25	0.73	-3.70	4	7	2009-01-15 18:05:59	2005-01-25 14:39:32	6	1	2	0	0	7	0	17.00	59	100.00	CHANGED	GVGDhhRKlVosIKNVV	GVhDhhRKlsoslKNlV	0	0	0	0
+7936	PF08104	Antimicrobial_9		Ponericin L family	Lee SC	anon	Short protein clustering	Family	This family consists of the ponericin L family of antimicrobial peptides that are isolated from the venom of the predatory ant Pachycondyla goeldii. Ponericin L family shares similarities with dermaseptins. Ponericin L may adopt an amphipathic alpha-helical structure in polar environments and these peptides exhibit a defensive role against microbial pathogens arising from prey introduction and/or ingestion [1].	25.00	25.00	59.50	59.40	20.60	17.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.73	0.72	-6.75	0.72	-4.15	2	2	2009-01-15 18:05:59	2005-01-25 14:40:06	6	1	1	0	0	2	0	24.00	96	100.00	CHANGED	LLKELWTKhKGAGKAVLGKIKGLL	LLKELWTKhKGAGKAVLGKIKGLL	0	0	0	0
+7937	PF08105	Antimicrobial10		Metchnikowin family	Lee SC	anon	Short protein clustering	Family	This family consists of the metchnikowin family of antimicrobial peptides from Drosophila.\	      metchnikowin is a proline-rich peptide whose expression is immune-inducible. Induction of the metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product. The metchnikowin peptide is unique among the Drosophila antimicrobial peptides in that it is active against both bacteria and fungi [1].	25.00	25.00	35.30	34.90	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.55	0.72	-4.34	2	13	2009-01-15 18:05:59	2005-01-25 14:40:48	6	1	12	0	7	13	0	51.90	66	99.70	CHANGED	MQLNLGAIFLALLGVMATATSVLAEPHRHQGPIFDTRPSPFNPNQPRPGPIY	MQLNL.GAI.FLALLGlhAsussl.huEsHR+QGPI.FDTRPSPFNPNQPR.P.GP.Y..	0	1	1	4
+7938	PF08106	Antimicrobial11		Formaecin family	Lee SC	anon	Short protein clustering	Family	This family consists of the formaecin family of  antimicrobial peptides isolated from the bulldog  ant Myrmecia gulosa in response to bacterial  infection. Formaecins are inducible peptide  antibiotics and are active against growing  Escherichia coli but were inactive against other  Gram-negative and Gram-positive bacteria. Formaecin peptides are 16 amino acids long, are rich in proline  and have N-acetylgalactosamine O-linked to a conserved  threonine [1].	25.00	25.00	41.80	41.80	14.90	14.30	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.42	0.73	-6.40	0.73	-3.90	2	2	2009-09-10 15:42:18	2005-01-25 14:41:15	6	1	1	0	0	2	0	16.00	88	100.00	CHANGED	GRPNPVNsKPTPaPRL	GRPNPVNsKPTPaPRL	0	0	0	0
+7939	PF08107	Antimicrobial12		Pleurocidin family	Lee SC	anon	Short protein clustering	Family	This family consists of the pleurocidin family of antimicrobial peptides. Pleurocidins are found in the skin mucous secretions of the winter flounder (Pleuronectes americanus) and these peptides exhibit antimicrobial activity against Escherichia coli. Pleurocidin is predicted to assume an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defense [1].	21.10	21.10	22.00	21.30	19.20	17.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.17	0.72	-4.41	4	43	2009-01-15 18:05:59	2005-01-25 14:41:37	6	1	23	3	1	50	0	39.40	46	61.12	CHANGED	MKhsAhFLVLSLVVLMAEPGEuFltalh+GlhHuGKhIHGhl	MKhsAhFLVL.lVVLMAEPGEsha.t.plh+GhhHsG+h.I+th......................	1	0	0	1
+7940	PF08108	Antimicrobial13		Halocidin family	Lee SC	anon	Short protein clustering	Family	This family consists of the halocidin family of antimicrobial peptides. Halocidins are isolated from the haemocytes of the tunicate, Halocynthia aurantium. They are dimeric in structures which are found via a disulfide linkage between cysteines of two different- sized monomers. Halocidins have been shown to have strong antimicrobial activities against a wide variety of pathogenic bacteria and could be ideal candidates as peptide antibiotics against multidrug-resistant bacteria [1].	25.00	25.00	34.60	33.90	21.30	20.00	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.24	0.73	-6.32	0.73	-3.79	2	3	2009-01-15 18:05:59	2005-01-25 14:42:07	6	1	1	0	0	3	0	15.00	100	34.88	CHANGED	ALLHHGLNCAKGVLA	ALLHHGLNCAKGVLA	0	0	0	0
+7941	PF08109	Antimicrobial14		Lactocin 705 family	Lee SC	anon	Short protein clustering	Family	This family consists of lactocin 705 which is a bacteriocin  produced by Lactobacillus casei CRL 705. Lactocin 705 is a class IIb bacteriocin, whose activity depends upon the  complementation of two peptides (705-alpha and 705-beta) of  33 amino acid residues each. Lactocin 705 is active against  several Gram-positive bacteria, including food-borne pathogens  and is a good candidate to be used for biopreservation of  fermented meats [1].	21.00	21.00	89.90	89.90	19.50	18.30	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.39	0.72	-4.13	2	2	2009-01-15 18:05:59	2005-01-25 14:42:34	6	2	2	0	0	2	0	31.00	100	72.94	CHANGED	GMSGYIQGIPDFLKGYLHGISAANKHKKGRL	GMSGYIQGIPDFLKGYLHGISAANKHKKGRL	0	0	0	0
+7942	PF08110	Antimicrobial15		Ocellatin family	Lee SC	anon	Short protein clustering	Family	This family consists of the ocellatin family of antimicrobial peptides. Ocellatins are produced from the electrical-stimulated skin secretions of the South American frog, Leptodactylus ocellatus.  The family consists of three structurally related peptides, ocellatin 1, ocellatin 2 and ocellatin 3.  These peptides present hemolytic activity against human erythrocytes and are also active against Escherichia coli [1].	22.70	22.70	23.10	36.00	21.00	22.60	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.27	0.73	-6.55	0.73	-3.64	3	5	2009-01-15 18:05:59	2005-01-25 14:43:01	7	1	3	0	0	5	0	19.00	62	81.20	CHANGED	VLDILKGAAKDLLAHlAsK	VLDILKGAAKDLLAHlAsK	0	0	0	0
+7943	PF08111	Pea-VEAacid		Pea-VEAacid family	Lee SC	anon	Short protein clustering	Family	This family consists of the PEA-VEAacid neuropeptides  family. These neuropeptides are isolated from the  abdominal perisympathetic organs of the American cockroach.  These peptides are found together with Pea-YLS-amide and Pea-SKNacid, giving a unique neuropeptide pattern in abdominal  perisympathetic organs. The functions of these neuropeptides  are unknown [1].	25.00	25.00	44.20	44.10	23.00	19.50	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.31	0.74	-6.14	0.74	-3.46	2	2	2009-01-15 18:05:59	2005-01-25 14:45:27	6	1	1	0	0	2	0	15.00	93	93.75	CHANGED	LsLTPGSHVDSYVEA	LsLTPGSHVDSYVEA	0	0	0	0
+7944	PF08112	ATP-synt_E_2		ATP synthase epsilon subunit	Lee SC	anon	Short protein clustering	Family	This family consists of epsilon subunits of the ATP  synthase. The ATP synthase complex is composed of an  oligomeric transmembrane sector (CF0), and a catalytic  core (CF1). CF1 is composed of 5 subunits, of which  the epsilon subunit functions as a potent inhibitor of  ATPase activity in both soluble and bound CF1. Only  when the epsilon inhibition is disabled is high  ATPase activity detected in ATPase [1]	25.00	25.00	25.30	25.30	24.70	21.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.81	0.72	-3.90	2	15	2009-01-15 18:05:59	2005-01-25 14:48:08	6	1	15	0	4	6	0	50.40	71	92.87	CHANGED	Msp......DKYlpIL+spL-pKKsElLppINMEYEKhLKpRLspL-clKtplLKE	.....MDQ......DKYLQILRSSLEEKKSEILKNVNAEYEKLLKNRLNQLDEVKRKVLKE	0	1	1	3
+7945	PF08113	CoxIIa		Cytochrome c oxidase subunit IIa family	Lee SC	anon	Short protein clustering	Family	This family consists of the cytochrome c oxidase subunit IIa family.  The bax-type cytochrome c oxidase from Thermus thermophilus is known as a two subunit enzyme. From its crystal structure, it was discovered that an additional transmembrane helix 'subunit IIa' spans the membrane.  This subunit consists of 34 residues forming one helix across the membrane. The presence of this subunit seems to be important for the function of cytochrome c oxidases [1].	20.70	20.70	23.20	22.60	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.39	0.72	-4.23	2	13	2009-01-15 18:05:59	2005-01-25 14:49:03	6	1	13	27	5	11	0	34.30	59	88.49	CHANGED	MEEKPKGALAVILVLTLTILVFWLGVYAVFFARG	.......MEEK...PpGALuVIhVLTlTILVFWhGVaAlFhARG.	1	1	4	5
+7946	PF08114	PMP1_2		ATPase proteolipid family	Lee SC	anon	Short protein clustering	Family	This family consists of small proteolipids associated with the plasma membrane H+ ATPase. Two proteolipids (PMP1 and PMP2) are associated with the ATPase and both genes are similarly expressed in the wild-type strain of yeast with no modification of the level of transcription of one PMP gene is detected in a strain deleted of the other. Though both proteolipids show similarity with other small proteolipids associated with other cation -transporting ATPases, their functions remain unclear [1].	22.10	22.10	22.30	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.22	0.72	-4.47	2	29	2009-01-15 18:05:59	2005-01-25 14:51:50	6	1	21	0	18	21	0	39.90	63	68.42	CHANGED	M...TLPGGVILVFILVGLACIAIIuTIIYRKWQARQRGLQRF	...........LPGGVILVFILVGLAsIAIluTIIYRKWQARQRuLQRF.....	0	3	8	16
+7947	PF08115	Toxin_28		SFI toxin family	Lee SC	anon	Short protein clustering	Family	This family consists of the SFI family of spider toxins. This family of toxins might share structural, evolutionary and functional relationships with other small, highly structurally constrained spider neurotoxins. These toxins are highly selective agonists/antagonists of different voltage-dependent calcium channels and are extremely valuable reagents in the analysis of neuromuscular function [1].	25.00	25.00	39.90	39.90	23.40	18.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.96	0.72	-4.29	2	10	2009-01-15 18:05:59	2005-01-25 14:53:16	6	1	1	0	0	10	0	33.30	79	79.10	CHANGED	+psMsDEoVCYIpspNsssGpCLp.pusaAcPWEh	.KECMsDGTVCYIHNHNDCCGSCLC.NGPlARPWEM.	0	0	0	0
+7948	PF08116	Toxin_29		PhTx neurotoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of PhTx insecticidal neurotoxins that are found in the venom of Brazilian, Phoneutria nigriventer. The venom of the Phoneutria nigrivente contains numerous neurotoxic polypeptides of 30-140 amino acids which exert a range of biological effects.  While some of these neurotoxins are lethal to mice after intracerebroventricular injections, others are extremely toxic to insects of the orders Diptera and Dictyoptera but had much weaker toxic effects on mice [1].	25.00	25.00	68.20	68.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.79	0.72	-4.16	4	6	2009-01-15 18:05:59	2005-01-25 14:55:43	6	1	4	0	0	6	0	31.00	72	96.88	CHANGED	AFC+aNGQQCTSDGQCCpG+ChTAFhG+ICM	sFCRaNGQQCTSDGQCCaG+C+TAFhG+ICM	0	0	0	0
+7949	PF08117	Toxin_30		Ptu family	Lee SC	anon	Short protein clustering	Family	This family consists of toxic peptides that are  isolated from the saliva of assassin bugs. The  saliva contains a complex mixture of proteins  that are used by the bug either to immobilise  the prey or to digest it. One of the proteins (Ptu1)  has been purified and shown to block reversibly the  N-type calcium channels and to be less specific for  the L- and P/Q- type calcium channels expressed in  BHK cells [1].	24.50	24.50	24.90	79.10	24.20	23.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.03	0.72	-3.92	2	3	2012-10-01 22:06:18	2005-01-25 14:56:59	6	1	3	2	0	3	0	34.70	57	99.05	CHANGED	A-cDCls.Gu.ChGpsK.CCp.+shC..YAN+C..l	AD-DCLPRGSKCLGENKQCCc.+TTCMFYANRCVGl.	0	0	0	0
+7950	PF08118	MDM31_MDM32		Yeast mitochondrial distribution and morphology (MDM) proteins 	Mistry J, Wood V	anon	Pfam-B_37122 (release 16.0)	Family	Proteins in this family are yeast mitochondrial inner membrane proteins MDM31 and MDM32.\	      These proteins are required for the maintenance of mitochondrial morphology, and the stability of mitochondrial DNA [1].	18.20	18.20	38.10	18.40	17.20	17.70	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.66	0.70	-6.04	5	247	2009-01-15 18:05:59	2005-01-25 16:36:47	6	4	139	0	186	252	0	358.20	32	76.81	CHANGED	cRDQLLAQAoNhauRLRIRLKWhLKRS.NRPFNTDDISAFlSWlLVSNsLLlFLuTTTFlSLVIYLhNTVFAQEYVAcKlGNFLTKNSALTVVFESAIVPDWSSGKISF+KVFVSRRPKpscuFoKGSQ+EAsERAKLALSEsLLVscE-FDDGNYTQFDLTIDQV-ISLSLsKWINGKGhlDEVpINGLRGVVDRTHVaWKssDDARNYKNVHQPGDFEISsF+MNDVLFTLYQPuGFRPFpVSIFNCELPQLRKHWLFYDFLNANsMSGoYDNSMFTIHKKa+pcDhsc...psSsSssW+KVTRMRVDSLNIDHLNAGlEGPFGWITSGKVDMIGDVLLP--NtDslsLSELLTlIuDRIlKEA+RYpNhlPtpKs-pPDI..........DlccYFVMDFoLRLNNVRAcVPLFTPELSYINNALIRPIVGYINSKRTYIPI+CRVVKNLsDFuGSWTIYDShLMDDLSAEVYDAFA-YVAD-EpRslRMKRVGFWSLQLLlQLILhSLGAIA	.........................................................+tphL..spshhp+hhlph+Wh.h+s..Rsas.--..h..sshhSWhhhuphhhhhluTTTFhuhhhh.h....N.....oh....p-hls...t.h.l.....uphhs......t...hph.hpp.shhst.ht.....pshI.hp.ps.l...................................................................................................................................................................................................................p..hhpa-lplpplsloLSh.pWhpGpGhlpphpl.GlRG...........hl...........shp.................p..h..........t..................s..............h.....t.h...hp.....hp......s.......sa.EhpphphpDhhhplhpst.s.h.ps.....hphSIashclspLRtpalhhDhhsAp.hsGshssShFol.....H.pQ...h.......t.........t..........................................a.pp.........hsRhRlDslplscLp..t.....sh...p.ushsWIhpGpl-hluDlhhPt.p....t..p...................t.....th....h..........h............................................................................................................................p.....hhh.hshplph.sl+A.hP................ths.....hhs.s.....l.....RslluahN............s...p....pp.....l.lpsph...htphts..ph.pshhhp.h..th...................Ytth...l...pt...p..p.c....Ws.p..............tt....................................................................	0	51	109	166
+7951	PF08119	Toxin_31		Scorpion acidic alpha-KTx toxin family	Lee SC	anon	Short protein clustering	Family	This family consists of acidic alpha-KTx short chain scorpion toxins. These toxins named parabutoxins, block voltage-gated K channels and have extremely low pI values. Furthermore, they lack the crucial pore-plugging lysine. In addition, the second important residue of the dyad, the hydrophobic residue (Phe or Tyr) is also missing [1].	25.00	25.00	90.40	90.30	22.30	21.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-8.05	0.72	-4.42	2	3	2009-01-15 18:05:59	2005-01-25 16:49:08	6	1	2	0	0	3	0	36.70	93	100.00	CHANGED	DEEPKEoCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD	DEEPKETCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD	0	0	0	0
+7952	PF08120	Toxin_32		Tamulustoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of the tamulustoxins which are  found in the venom of the Indian red scorpion (Mesobuthus  tamulus). Tamulustoxin shares no similarity with other  scorpion venom toxins, although the positions of its six  cysteine residues suggest that it shares the same  structural scaffold. Tamulustoxin acts as a potassium channel  blocker [1].	25.00	25.00	97.40	97.30	16.70	16.70	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.97	0.72	-4.35	2	2	2009-01-15 18:05:59	2005-01-25 16:50:44	6	1	1	0	0	2	0	35.00	97	100.00	CHANGED	RCHFVlCTTDCRRNSPGTYGECVKKEKGKECVCKS	RCHFVlCTTDCRRNSPGTYGECVKKEKGKECVCKS	0	0	0	0
+7953	PF08121	Toxin_33		Waglerin family	Lee SC	anon	Short protein clustering	Family	This family consists of the lethal peptides (waglerins)  that are found in the venom of Trimeresurus wagleri.  Waglerins are 22-24 residue lethal peptides and are  competitive antagonist of the muscle nicotinic receptor  (nAChR). Waglerin-1 possesses a distinctive selectivity  for the alpha-epsilon interface binding site of the mouse  nAChR [1].	25.00	25.00	25.70	57.80	24.10	15.40	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.73	0.72	-6.95	0.72	-4.35	2	2	2009-01-15 18:05:59	2005-01-25 16:51:09	6	1	1	0	0	2	0	22.00	95	91.67	CHANGED	GGKPDLRPCaPPCHYIPRPKPR	GGKPDLRPCaPPCHYIPRPKPR	0	0	0	0
+7954	PF08122	NDUF_B12		NADH-ubiquinone oxidoreductase B12 subunit family	Lee SC	anon	Short protein clustering	Family	This family consists of the NADH-ubiquinone  oxidoreductase B12 subunit proteins. NADH is the  central source of electrons in the mitochondrial  and bacterial respiration. NADH-ubiquinone  oxidoreductase is involved in the transfer of  electrons from NADH to the electron transport  chain. This oxidation of NADH is coupled to  proton transfer across the membrane, generating  a proton motive force that is utilised for the  synthesis of ATP. The function of this subunit is unclear [1].	22.70	22.70	22.70	23.40	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.98	0.72	-4.23	13	205	2009-01-15 18:05:59	2005-01-25 17:17:10	7	3	190	0	146	193	0	56.50	39	58.04	CHANGED	LRDPWuRNEAWRY.hssFuppho.hhsshF+GFtaG.FuAFVlslulE.....ahhtssc+sp.H	....+DPWtRsEAWRY..pGsFu.c....hs......hhcshh.....Ghshu.hs.AFs.shluhE......ah.l..p.sp..c+p.................	0	49	73	111
+7955	PF08123	DOT1		Histone methylation protein DOT1 	Mistry J, Wood V	anon	Pfam-B_12064 (release 16.0)	Domain	The DOT1 domain regulates gene expression by methylating histone H3 [1]. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.18	0.71	-5.02	11	554	2012-10-10 17:06:42	2005-01-25 17:38:26	8	19	328	15	391	1008	656	161.00	26	26.32	CHANGED	YsRuV.PcspcL+.cYcuFSspVYGELhPsFloslhpcssLsssclFhDLGSGVGNsVlQAALEhGCchSaGCElM-sASclAEtQhcEhcp+hphaGh+hsplcat.+tSFlsN-clcpllspsDVlLVNNFhFDspLNppl.pchltsLKsGsKIISLKshtsssap.Is.csh-sIhshL+Vpchshscs.SVSWTsps.ssYYISTl	..............................................................sYGEh...............t...hl.sp....l...h....p....p.h....p......l...p.p..........s..s..........l.FlDLGSGlGp...ll............hQsA.hph.s.sc........s..hGlEh.h........pp.h..s.p..h...A.........pt........t..t..h..p....t.........h.h....t......h.h...s....h..t......h.....php....h...ps....s..hh.p....t.........h.................h.......tp...ss..llhhN..s...........h..h......F..s...........p.l.t....tl.....p.h.h.......p.h...t.....G.sp.l.l.o...p...hh........................................................................................................................................................................................................................................................	1	140	218	354
+7956	PF08124	Lyase_8_N		Polysaccharide lyase family 8, N terminal alpha-helical domain	Mistry J	anon	Pfam-B_2438 (release 16.0)	Family	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	24.00	24.00	24.90	24.20	21.40	23.90	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.96	0.70	-5.56	26	980	2012-10-02 15:11:41	2005-01-31 09:02:22	6	52	764	44	96	695	5	312.20	30	35.54	CHANGED	Wtshl......hGsp.hsssssshtshhpphsppup.p.hsshp...psspshLWpcls........tpssoupl..Tssap+LpphApAappPsSshapssslhssIhcuLcahppphYssspp.................phG.NWWcWpIGsPpulsshLlLha-tlo...psclssYssslc+FsP-P.............sht....hpuTGANpsDhupshllcGlLpcDssclppuhcuLss........VashVspG......DGFYpDGSaIQH...........sslsYTGuYGsVLlcGlupLhsllpsosaslss.phsslachlccuahPllhcGtMMDhlRGRuISRtssp.........s+..stGtsllpullhl.uphussspp..tchpuhlKs	................................................................................W.sh.hG..p.ac..pps.phtphhpt..h-p.....c.s...t.....p.....hlpshpp....pss.Rs..h..L.Wpshp...............................ppS.ush....Tpoa+plcchApsh..p....sP.....s....op..h.a..p-....pplhptlh-ul-ah.pcphYs.s..p.s......................hu..NWWDaE.........IGsP+ulssTLhLhp...-.h..ho..............s-.chpp..ao.ss.Icp...FsPDs................tthh..ohs....shtu.......pG..uNhlDhu..+s..hlhpull....p.c.......Ds.p.p......lpp...ulc...ulsp...............V..F..ph...Vs..pu...................-.GFYpDGSaIpH..............ssVsYTG.uYGs.V.L...lcGluplhsllpt.....T....tas..h..s..spp..pslhpal-c..u.FhPll.hp.G.....ch.....h.D.h.s.RGRu.ISRtspp.........u+.....stuh.plhpulhhl.uc.h..sppp..tchpphlK..................................................................................	0	54	80	93
+7957	PF08125	Mannitol_dh_C		Mannitol dehydrogenase C-terminal domain	Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.80	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.61	0.70	-5.20	16	5053	2012-10-02 19:36:47	2005-01-31 18:33:56	8	18	2344	4	791	3180	477	232.20	31	52.45	CHANGED	ppVuFPsshVDRIVPt...........thuhcDPhsVssEPFhpWVlEcshhpG.ss...hchsGsphVsclpPY.EhKLhhLNuuHuslAYlGaLtGhphlcEuhpDtplpthlcshhtEphtsllshh...sts-LpsYtspllpRFpNPhIpDplpRluhs.....PhRhLsshcchlt...shhchhshs.tsahphlpGlstshphhp.sDsputplpt..........hhspcpspshLu.hshhtt-h.pssph	..............................................pVsFssohVDRIVPs...........s....t...........h...............h....................p...........t...........h.....G.h.p..D............s............h.........................V............s............s............E......s.F..t..........p............W....VlE..c.s.h..h.....t.G...p..s...............h..c.h.....s..G....sp....h..V...s...D...l...h...PacEh..KL.t.h.LNuuHoh.lA....Yl...Gh....L...u..G...a...p....pIt-shp.D.sth.......cthsc.t...hhh...c.-tt...s.h..l.ph........sss...-......h.psYt.p.....p.l.l.t.RF..pN...P...hlccpshplAhss.pKh..P..h..RhLssh.c.thlpt....t.....s..........h....t....h..L....s.....h.....u....Au.a....h.pa...l..........p......G..........l...........s..........t............t.........t.........p..........h.........h.s..........s..D..s.....h......phtp....................h...s...p...p.t.....sp....s....h....Lu.....shhsts.......h..................................................................	1	196	439	611
+7958	PF08126	Propeptide_C25		Propeptide_C25	Mistry J	anon	Rawlings N	Motif	This is found at the N terminal end of some of the members of the C25 peptidase family (PF01364).  Little is known about the function of this motif.	20.30	20.30	22.30	20.70	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.23	0.71	-5.32	4	56	2009-01-15 18:05:59	2005-02-01 17:12:27	6	18	27	0	24	60	111	185.60	21	14.11	CHANGED	QsschttsPs....lphltssppSho+lpFc..hsplpFTpVpTpcG..shQssohstusshuEhGpPpLPlLp+.lAVs-..Ttsh+Vclhoochh-ppsl...hlsPopssh.+sEsP-plPY......l.upuYupstFhPuElsslspshhhRsVRhtsVshsPlQYNPVsppL+lhscIpVsVS.su.....ppspshhshhcsSsFssFEssYKphF	......................................................................................................................tts.....hp..hp..h.th.htphp.h.tt..hht.hshst.sh.....hsch.G.PpLPh.hpp.lulPs...s.hp..hpVps.ss.sp.h..hph.psh....hlhP.sps..h.csp.s..Pp...p.lsa.........hpspsYspspaaPsplsplspshhhRsh+stslshtPlQYNPVoppL+l....hsplplplohpu........tpt.t................................................	0	17	22	23
+7959	PF08127	Propeptide_C1		Peptidase family C1 propeptide	Mistry J	anon	Rawlings N 	Motif	This motif is found at the N terminal of some members of the Peptidase_C1 family (Pfam:PF00112) and is involved in activation of this peptidase [1].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.83	0.72	-4.33	60	407	2009-01-15 18:05:59	2005-02-02 09:21:42	8	5	183	5	123	418	2	41.70	37	13.35	CHANGED	LS--hIphINp.p.ssTWKAG+N..F.tshohspl+pLhGs.h.sss	.....LS--hlshINc.p.ssTW+AG+N...F...shs....hs.h+pLhGs.hhps...........	0	61	73	99
+7961	PF08129	Antimicrobial17		Alpha/beta enterocin family	Lee SC	anon	Short protein clustering	Family	This family consists of the alpha and beta enterocins and  lactococcin G peptides. These peptides have some antimicrobial  properties; they inhibit the growth of Enterococcus spp. and a  few other gram-positive bacteria. These peptides act as pore- forming toxins that create cell membrane channels through a  barrel-stave mechanism and thus produce an ionic imbalance in  the cell. These family of antimicrobial peptides belong to the  class II group of bacteriocin [1].	25.00	25.00	26.80	26.50	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.73	0.72	-4.19	2	7	2012-10-02 23:56:30	2005-02-22 13:49:07	6	1	4	2	0	8	0	46.40	57	90.78	CHANGED	MKQYKVLNEKEMKKsIGGESVFSKIGNAVGPAAYWILKGLGNMSDVNQADRINRKKH	.......K.LsEKEh+pslGG....scIGpulG.sAYWlhKuhGNMSDVNQAsRINRKK.t..............	0	0	0	0
+7962	PF08130	Antimicrobial18		Type A lantibiotic family	Lee SC	anon	Short protein clustering	Family	This family consists of the type A lantibiotic peptides. Both Pep5  and epicidin-280 are ribosomally-synthesised antimicrobial peptides  produced by Gram-positive bacteria that are characterised by the  presence of lanthionine and/or methyllanthionine residues. The  lantibiotics family has a highly specific activity against multi- drug resistant bacteria and has potential to be utilised in a wide range of medical applications [1,2].	25.00	25.00	31.80	31.60	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.98	0.72	-4.09	2	6	2009-09-11 06:04:39	2005-02-22 13:49:58	6	1	4	0	0	4	0	53.30	58	100.00	CHANGED	McNpKsLFDLEIKK-s.pNssELEsQohGPAI+Aohp.C....KATRhhTVSCK.KssCp	M...NKELFDLDINK.pMEsPTEMTsQThGTslKVS+ulCK...puTCIsTISCo...NC.K	0	0	0	0
+7963	PF08131	Defensin_3		Defensin-like peptide family	Lee SC	anon	Short protein clustering	Family	This family consists of the defensin-like peptides (DLPs) isolated from platypus venom. These DLPs show similar three-dimensional fold to that of beta-defensin-12 and sodium-channel neurotoxin Shl. However the side chains known to be functionally important to beta-defensin-12 and Shl are not conserved in DLPs. This suggests a different biological function. Consistent with this contention, DLPs have been shown to possess no anti-microbial properties and have no observable activity on rat dorsal-root-ganglion sodium-channel currents [1].	17.70	17.70	17.70	18.00	17.50	17.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.20	0.72	-3.98	2	9	2012-10-01 20:50:19	2005-02-22 13:51:53	6	1	3	4	8	11	0	38.40	44	68.38	CHANGED	ac.psC.ShsGVCRcKsphNC+.hhhs.C.NcpQKCCch	.......ptCpshuGVCRcKss+NC+sIhhs.CcNRNp+CCc...	1	0	0	6
+7964	PF08132	AdoMetDC_leader		S-adenosyl-l-methionine decarboxylase leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the S-adenosyl-l-methionine decarboxylase (AdoMetDC) leader peptides. AdoMetDC is a key regulatory enzymes in the biosynthesis of polyamines. All expressed plant AdoMetDC mRNA 5' leader sequences contain a highly conserved pair of overlapping upstream ORFs (uORFs) that overlap by one base. Sequences of the small uORFs are highly conserved between monocot, dicot and gymnosperm AdoMetDC mRNA species, suggesting a translational regulatory mechanism [1].	25.00	25.00	55.60	55.00	17.20	17.00	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.69	0.72	-4.03	3	44	2009-01-15 18:05:59	2005-02-22 13:56:19	6	3	24	0	23	40	0	50.70	78	40.31	CHANGED	MESKGGKKKSSSSSSpsoLFFEAPLGYSIEDVRPNGGIKKFRSAAYSNCo+KPS	........MESKGGKKKSSSSsS...LhYEAPLGYSIEDVRPsGGIKKFRSAAYSNCu++PS.....	0	4	18	23
+7965	PF08133	Nuclease_act		Anticodon nuclease activator family	Lee SC	anon	Short protein clustering	Family	This family consists of the anticodon nuclease activator proteins.  Pre-existing host tRNAs are reprocessed during bacteriophage T4 infection of certain Escherichia coli strains. In this pathway, tRNA(Lys) is cleaved 5' by the anticodon nuclease to the wobble base and is later restored in polynucleotide kinase and RNA ligase reactions [1].	25.00	25.00	36.50	36.30	18.50	16.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-7.23	0.72	-4.45	2	15	2009-01-15 18:05:59	2005-02-22 13:59:57	6	1	14	0	0	9	0	25.40	82	96.21	CHANGED	MSNFHNEHVMQFYRNNLKshGlhGhp	.MSNFHNEHVMQFYRNNLKTKGVFGRp..	0	0	0	0
+7966	PF08134	cIII		cIII protein family	Lee SC	anon	Short protein clustering	Family	This family consists of the cIII family of  regulatory proteins. The lambda CIII protein  has 54 amino acids and it forms an amphipathic  helix within its amino acid sequence. Lambda  cIII stabilises the lambda cII protein and the  host sigma factor 32, responsible for transcribing  genes of the heat shock regulon [1]. 	25.00	25.00	64.30	64.20	23.90	23.20	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.28	0.72	-4.36	3	42	2009-01-15 18:05:59	2005-02-22 14:20:08	6	1	42	0	2	15	0	43.80	89	98.29	CHANGED	MMHFQLAGSGVMSAFYPHESELSRRVKQLIRAAKKQLEALCAMK	MMHFQLAGSGVMSAFYPHESELSRRVKQLIRAAKKQLEALCAMK....	0	0	0	1
+7967	PF08135	EPV_E5		Major transforming protein E5 family	Lee SC	anon	Short protein clustering	Family	This family consists of the major transforming proteins (E5)  of the bovine papilloma virus (BPV). The equine sarcoid is  one of the most common dermatological lesion in equids. It is  a benign, locally invasive dermal fibroblastic lesion and  studies have shown an association of the lesions with BPV. E5  is a short hydrophobic membrane protein localising to the Golgi  apparatus and other intracellular membranes. It binds to and  constitutively activates the platelet-derived growth factor-beta  in transformed cells. This stimulation activates a receptor  signaling cascade which results in an intracellular growth  stimulatory signal [1].	25.00	25.00	37.10	36.90	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.50	0.72	-3.97	3	23	2009-01-15 18:05:59	2005-02-22 14:21:20	6	1	6	0	0	22	0	42.30	82	99.79	CHANGED	Msa.GLLLFLGLTFAlQLLLLVFLLFFFLVWWDQFGCRC-Gh.L	MPNLWFLLFLGLVAAMQLLLLLFLLLFFLVYWDHFECSCTGLPF.	0	0	0	0
+7968	PF08136	Ribosomal_S22		30S ribosomal protein subunit S22 family	Lee SC	anon	Short protein clustering	Family	This family consists of the 30S ribosomal proteins subunit  S22 polypeptides. This polypeptide is 47 amino acids in length  and has a molecular weight of about 5 kDa. The S22 subunit is a  component of the stationary-phase-specific ribosomal protein and  is assembled in the ribosomal particles in the stationary phase.  This subunit along with other stationary-phase-specific ribosomal  proteins result in compositional changes of ribosomes during the  stationary phase. The significance of this change is not clear as  yet [1].	25.00	25.00	26.00	25.30	24.00	23.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.05	0.72	-3.81	3	402	2009-12-01 13:51:23	2005-02-22 14:28:17	6	1	400	0	14	34	0	44.90	88	97.59	CHANGED	MKSNRQARHILGLDYKLSNQRKVVIEGDsEoVVTHATGRKRHA-K	..MKSNRQARHILGLDHKISN.QRKIVTEGDKSSVV..N..N..PTGRKRPAEK............	0	1	2	8
+7969	PF08137	DVL		DVL family	Lee SC	anon	Short protein clustering	Family	This family consists of the DVL family of proteins.  In a gain-of-function genetic screen for genes that influence fruit development in Arabidopsis, DEVIL (DVL) gene was identified. DVL is a small protein and overexpression of the protein results in pleiotropic phenotypes featured by shortened stature, rounder rosette leaves, clustered inflorescences, shortened pedicles, and siliques with pronged tips. DVL family is a novel class of small polypeptides and the overexpression phenotypes suggest that these polypeptides may have a role in plant development [1].	19.60	19.60	19.70	22.30	18.50	19.20	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.20	0.72	-6.21	0.72	-4.48	20	182	2009-09-11 09:54:20	2005-02-22 14:32:13	7	4	18	0	129	166	0	19.00	66	23.47	CHANGED	KEQRuRhYIlRRClsMLlC	.KEQRARhYIlRRCVsMLlC...	0	24	81	101
+7970	PF08138	Sex_peptide		Sex peptide (SP) family	Lee SC	anon	Short protein clustering	Family	This family consists of Sex Peptides (SP) that are found in Drosophila. On mating, Drosophila females decreases her remating rate and increases her egg-laying rate due, in part, to the transfer of SP from the male to the female. SP are found in seminal fluids transferred from the male to the female during mating. The male seminal fluid proteins are referred to as accessory gland proteins (Acps). The SP is one of the most interesting Acps and plays an important role in reproduction [1].	25.00	25.00	53.90	53.80	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.08	0.72	-4.12	5	23	2009-01-15 18:05:59	2005-02-22 14:41:42	6	1	10	1	2	24	0	52.70	57	99.51	CHANGED	M+sPl.LhLllL..LlGlAhuh...hscRsc.....susIhGP+DRcKWCRLNLGPAWGGRsC	....MKs.hhhLlLVh..lLGLs.uhpWPhs++ss.....+hsI.SPpsR-KWCRLNLGPAWGGR.C	0	2	2	2
+7971	PF08139	LPAM_1	VirB;	Prokaryotic membrane lipoprotein lipid attachment site	Lee SC, Bateman A	anon	Short protein clustering	Motif	In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.71	0.73	-7.05	0.73	-3.54	71	711	2012-10-01 23:27:00	2005-02-22 14:43:14	7	16	567	0	60	226	22	24.40	62	12.78	CHANGED	M...................................++hhhhhhhhh...LuuCuo	.....................................................MhKKILFPLlALFh..LAGCAp.	0	6	22	43
+7972	PF08140	Cuticle_1		Crustacean cuticle protein repeat	Lee SC	anon	Short protein clustering	Family	This family consists of the cuticle proteins from the Cancer  pagurus and the Homarus americanus. These proteins are isolated  from the calcified regions of the crustacean and they contain two  copies of an 18 residue sequence motif, which thus far has been  found only in crustacean calcified exoskeletons [1].	21.40	21.40	21.40	26.00	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-7.95	0.72	-4.13	38	90	2009-01-15 18:05:59	2005-02-22 14:44:51	6	6	6	0	0	82	0	40.00	45	71.21	CHANGED	GsSGllhsDGp.hQhstsh..sl..lLhGPSGhVhusGcslQh	.....G.SGllhsDGp.hQhstsh..sl..llhGPSGhVhusGcNlQh......	0	0	0	0
+7973	PF08141	SspH		Small acid-soluble spore protein H family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins  (SASP) of the H type (sspH). SspH are unique to spores of Bacillus  subtilis and are expressed only in the forespore compartment  during sporulation of this organism. The sspH genes are  monocistronic and are recognised by the forespore-specific  sigma factor for RNA polymerase - sigma-G. The specific role  of this protein is unclear but is thought to play a role in  sporulation under conditions different from that of the common laboratory tests of spore properties [1].	25.00	25.00	51.10	51.00	21.30	17.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.72	0.72	-3.92	20	329	2009-01-15 18:05:59	2005-02-22 14:48:28	7	1	194	0	59	184	1	57.70	46	94.31	CHANGED	M.-spRAKcIlsSsshlsVoYpGsPVaI-cVs.EpscsApla.l.ssspccpcVslssLcE	..MslpRAKpIhsSspphsVoa.pG.hPVaIppVD.EpspsAplYpl.sN.PscchpVsVssLcE.......	0	19	39	43
+7974	PF08142	AARP2CN		AARP2CN (NUC121) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is the central domain of AARP2.  It is weakly similar to  the GTP-binding domain of elongation factor TU [1].	21.50	21.50	21.50	25.10	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.67	0.72	-4.45	73	707	2009-01-15 18:05:59	2005-02-22 15:35:56	7	33	318	0	470	699	8	82.40	35	9.33	CHANGED	-htNLhRhlssh+..+slsWRss+sYllu-chch...hsssp..t................................plslhGalRGss.hss..sphVHIsGhGDFplspI.ptlsDPs	......................................EhpNLhRhlsshK..+.slpW..Rss+sYlLu-chc.....hsssppht............................................tslslhGYlRGps....Lps.....s..........phVHIsGhG..DFplspl.phhsDP............................	0	170	265	390
+7975	PF08143	CBFNT		CBFNT (NUC161) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in proteins of CARG-binding factor A-like proteins [1].	21.70	21.70	21.80	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.89	0.72	-2.88	16	125	2009-01-15 18:05:59	2005-02-22 15:43:46	6	4	36	2	37	95	0	66.10	44	21.96	CHANGED	MS...E-Qhhpss..st.....sGpcuss-ppus...tshtGs.u..............................sussssAEGspI-ASKNEEDsGK	.........................MS...EpQ.htss..st.....sG..uss-tpush..ssttussu....................uG...tsusssss...sGssstAEGspIsASKNEEDtGK.	0	2	7	16
+7976	PF08144	CPL		CPL (NUC119) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is fund in Penguin-like proteins associated  with Pumilio like repeats [1].	20.70	20.70	20.70	21.40	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.72	0.71	-4.36	8	270	2009-01-15 18:05:59	2005-02-22 15:44:06	6	5	231	0	193	266	1	141.50	26	20.63	CHANGED	lssKYGRKVLLYLLuPRDssHFhPEIIclLccGD....sNAaSKKDsplRR+ELLEuISPsLLchls-cup-llhDpussllVuDILssssGDspsshs.AlAplAsp-h.suuh-G-hHIuccPAGHhsLKhLIpQD+chtEsGKEspFu+s	.....................................h..spauR+slLY.Lls.s..t......sstah...s......s...p....h...l.p.h.L.pcsc............tsspSKKDspl...RRpELl..c...uho...P...s....LLphl....sp.....p.....s.........p.........pllp.s....sh....us.hls.-........l.Lh..........s......u.s..........G...........-.p.p..s.s.hp....A.lAph.s.....sp..p.........................t..............t..........t..t...p..................+hh.pp.shuthhL.KhLlptsp.......................................................................................	0	59	99	157
+7977	PF08145	BOP1NT		BOP1NT (NUC169) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in BOP1-like WD40 proteins [1].	25.00	25.00	25.30	25.40	21.80	24.50	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.59	0.70	-4.65	38	353	2009-01-15 18:05:59	2005-02-22 15:44:34	7	9	289	0	249	359	9	244.50	45	35.02	CHANGED	Y--hsHIGYDlsGKKIhKst.ppstLDphLcsh-.cPcs..........W...RslhDthsscslpLoc--Lcll+Rlppuchsspsa-sYpshl-aFs..tcttlh..PlossP-P.KR+FlPS.KtEtK+lhKlV+AIRpGcIpspc.pcc........cpphYDlWscc.......tppptpphtclsAPKhsLPGap.ESYNPPsEYL.sccEcppWpph..c.c-RchpFlPp+asuLRpVPuYpchlpERFERCLDLYLsPRs++p+lsl.DPEsLlPKLPsP+-L+PFP	...................Y--hsHIGYDlsGK+Ih+Pt....pt-tLDphL-ph-.sP.c.h..........W...pslhD.toG.pslpLoc..--lcLlc+lp.psc..hscssas...PY...psh.l-aFo..tc.tlh..Pl.os.tP-s.KRpFlPS.+h.Et+..+VhKlV+AI+tGhIhs.+.hcp.............p.phYDLWus-...........p.ts.cphhalPAPKhs.PG.at.ESYNPPsEYL.sccEcptWppt.......-sp-R..........ch.pFlPp+asuLRpVPuYpchlcE......RFERCLDLYLsPRs..R...+....+.lNl.D.P.-sLlP+LPsPc-L+PFP...............	0	96	148	210
+7978	PF08146	BP28CT		BP28CT (NUC211) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in BAP28-like nucleolar proteins [1].	20.50	20.50	20.80	23.40	20.40	18.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.80	0.71	-4.49	29	300	2009-01-15 18:05:59	2005-02-22 15:45:25	7	10	246	0	210	299	0	152.00	29	8.80	CHANGED	Kpshsspps.lhchhLpAhDhRppp.........................phstpslsclEsplhss.hlphlhKLs-ssFRPLFhcLhcWAhst...tt........pssphpRhlsFa+hhsplt-sLKSlhosYhuall-sss.plLpph....................sssssss...........................hpLhphlLpsLppsFpaDp-pF	.........................pphsppts.lhphhLpAhDhRppp................................p.shpplsclEss....l...hcs.hlshlhKLs-ssFRPLFh+Lh-WAts................................psuptsRhloFYphhsplt-pLK................ulhTsahuallcsss.plLpps...............................................s.pptpp........................................htLhphlLp..sLppsFhaDpppF............................................	0	68	114	174
+7979	PF08147	DBP10CT		DBP10CT (NUC160) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in the Dbp10p subfamily of  hypothetical RNA helicases [1]. 	20.60	20.60	22.50	22.30	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.44	0.72	-4.16	23	302	2009-01-15 18:05:59	2005-02-22 15:49:32	7	8	257	0	208	294	1	63.70	37	7.59	CHANGED	DLssD-stt...htpp+phh+WD+KKpKaVsh.....uspsspKhI+uESGt+IsA.Sa+SG+a-cWpKp+	...........DLhsD-stp......hppppphh+WD+K+KKaVst..................suppsp..K..hI+sESGthI.s....A..S...a+.o..u.p....a.ccW+pp.p...	1	67	110	172
+7980	PF08148	DSHCT		DSHCT (NUC185) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases [1].	21.90	21.90	22.70	25.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.96	0.71	-5.04	102	1286	2009-01-15 18:05:59	2005-02-22 15:57:23	7	24	846	4	689	1241	370	174.30	29	17.64	CHANGED	hsssshs.pl..+GRlAscIpu...tsELllsEhlhsu.hhscLsPpclsAllSshVa-p+pssp.........ss............plpcshpp.......ltpltpcltplppcppl...........hhp.....p..phsLhplV..apWApGtsasplh..........phT.sl.EGslVRhh+Rlt-lLcQltpA.........hhusspLppphc.pAhphl+R..slVhtsShhl	.................................h...tthl.p...cGRlsscI...po...tsE...LllsEhlhsG.hassLsP.t.plAAl.lSshVapp+ssst..............ss.........................pLtpshpp........................................lp.c.l.tpclsplppc.ppl..............t.............hhpp...chslhcll..YpWAp.Gt.sasplh....................pho..-l.EGslVRhh+Rlt-lLcQl....tpA...............................hhu..s..spLtp....phc..pA.hptl+R..slVhhs.................................................	0	256	432	601
+7981	PF08149	BING4CT		BING4CT (NUC141) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in the BING4 family of nucleolar  WD40 repeat proteins [1].	20.90	20.90	22.50	20.90	20.60	18.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.58	0.72	-4.47	31	342	2009-01-15 18:05:59	2005-02-22 15:57:57	6	6	292	0	239	342	11	78.80	53	14.46	CHANGED	PYhsH..tsusplpslpFsPaEDlLGlGHspGFoSllVPGuGEsNaDuhE..sNPaETpKQRpEpEV+sLL-KLsPEhIoL-P	..................PYhsa....t.utplpslpFCPaEDVLGlGH.spG............aoSllVP..GAGEsNFDuhE..sNPaEo.pKQRpEtEV+uLL-Kl.PEhIsLDP..................	0	86	134	202
+7982	PF08150	FerB		FerB (NUC096) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is central domain B in proteins of the Ferlin family [1].	25.00	25.00	29.50	27.30	24.80	23.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.62	0.72	-3.91	5	436	2009-01-15 18:05:59	2005-02-22 16:00:55	7	62	72	0	247	370	0	75.70	48	4.27	CHANGED	PQNSlPDIhIWMlpG-KRlAYARIPAHQVLYSpss-ptsGKsCGKlQTlFLKYPt-KssGs...+VPVKlRVpLWLGLS	...PQsSlPDVhIWMlpssK.RlAYARlPA+plLaShs.p.p..tsG+pCGKlQTlFLK..............h..P..t....ccs..G................pls.uclclhlWLGL.....................	0	47	64	150
+7983	PF08151	FerI		FerI (NUC094) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is present in proteins of the Ferlin family.  It is often located between two C2 domains [1].	28.00	28.00	28.20	29.20	27.60	27.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.55	0.72	-3.96	16	414	2009-01-15 18:05:59	2005-02-22 16:01:35	7	51	80	0	250	369	4	71.60	46	3.94	CHANGED	lDlGhlYcpPsHtFh+KWslL......oDPcDp....puGsKGYlKlolhVlGp.............GDp...sshph.tsssscp-DIEsNLLl.PsGV	...........hDlGolYspP..s.......H..pah+KWhlL.......sDP.-.D.h......ouG.s.KGYlKsslsVlGp.............GDp...s.spp....+st.ss-p-DIEuNLLl.PtGh.................	0	52	73	156
+7984	PF08152	GUCT		GUCT (NUC152) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is the C terminal domain found in the RNA helicase II / Gu  protein family [1].	21.20	21.20	21.20	21.40	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.22	0.72	-4.00	19	241	2009-01-15 18:05:59	2005-02-22 16:02:17	7	10	123	1	143	235	2	96.60	33	14.30	CHANGED	Gaop.lcpRSLLouhcGaVTlhLpss.psh.shuasaphL+p.Ls-...ptsspl+slsLhtDs..pGsVFDVPp-.s-chhst.tcs.......uhpLsssppLPs..Lpp	........Ghop.hcpRSLloucpGalThhLpss....ppht..s..hu..aua+pLpc..pLu-....shss..clpphsl.lcsp....hGs.sFDVPsptsccl.pphpcs..............phpLolsscLPcLp..............................................	0	47	77	102
+7985	PF08153	NGP1NT		NGP1NT (NUC091) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in a subfamily of hypothetical nucleolar GTP-binding proteins similar to human NGP1 [1].	21.40	21.40	21.90	24.50	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.77	0.71	-4.19	37	376	2009-01-15 18:05:59	2005-02-22 16:02:59	7	9	299	0	254	366	3	128.30	43	21.82	CHANGED	MY+ph+shRstcGcllpst.hQ..sp.ptssARIcPsR+WFGNTRVIuQcsLppFR-thupptpDPYpVllKpsKLPhSLLp-s.....t+ppcs+l.l-sEsappTFGP.KupRKRP+.L.sssslE-LuppApp.pppsY	..................................MY+p..Ks..hRspcGcll+sstaQ.......sp..sss...sARl-PsR+WFGNTRVI.uQpuLppFR-phupphpDPYpVllKpsKLPMSLLp-p.......................+pp+s+l.l-TEsFpsTFGP.KuQRKRP+.L...sssslc-LsppuppptppY.........................	1	99	146	212
+7986	PF08154	NLE		NLE (NUC135) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is located N terminal to WD40 repeats.  It is found in  the microtubule-associated protein Swiss:Q12024 [1]. 	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.88	0.72	-3.96	66	603	2009-01-15 18:05:59	2005-02-22 16:03:45	7	15	305	0	433	599	6	64.60	28	13.67	CHANGED	plhlpFhocptt...phsssshhlPsslsp.hsLspllNp..LL..............psccslPF-Fllss.p....hl+soLpcal	...............lhlpFhopps...hphss.ssltlP.s....s.lsp.tpLspllNp..LL..........................psccsl..PasFhlps.p.........lpsoLtchh......................	0	154	243	360
+7987	PF08155	NOGCT		NOGCT (NUC087) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in the NOG subfamily of nucleolar GTP-binding proteins [1].	20.10	20.10	21.20	23.40	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.37	0.72	-4.28	29	370	2009-01-15 18:05:59	2005-02-22 16:04:31	6	11	298	0	245	355	1	53.40	52	8.46	CHANGED	+++Lp+DlEpE..pGGuGVYslDL+KpYhLts-EWKaDhlPEIhsG+NlsDFlDPDI	...............+RKLERDlE.E...uhussYslDL.+KpY.....Ltss-W.KaDhIPEIh-G+NlhDalDPDI....	0	87	138	203
+7988	PF08156	NOP5NT		NOP5NT (NUC127) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in RNA-binding proteins of the  NOP5 family [1].	21.60	21.60	22.00	21.70	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.99	0.72	-3.81	69	744	2009-01-15 18:05:59	2005-02-22 16:05:18	8	14	327	0	499	728	15	65.40	36	12.64	CHANGED	halLaEo...............uuGYuLFKlttctchhss...pltcphpshpphschVcLpuFp.FcsstpAL-sssslsEG	............halLaEo...............uuGYALF+lt.ctc....hss.......plt....cp.hpshp+hschV+LtuFp.Fp..ssspALc..s..ssulsEG...........................	1	178	282	416
+7989	PF08157	NUC129		NUC129 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in a novel family of hypothetical nucleolar proteins [1].	25.00	25.00	31.10	49.00	18.90	18.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.90	0.72	-4.06	4	38	2009-01-15 18:05:59	2005-02-22 16:06:17	6	1	32	0	22	34	0	61.20	66	27.01	CHANGED	YhssRLKDpshpsSpQpAAccFIpSpLYGPsosRTTsNchLSLpNKRussKtAAsQFlspsWu	.YlAVRLKDQDLRDSRQQAAcsFIpssLYGPGTNRTT.....VNKFLSLsNKRhPVKKAAVQFLNsuWG.	0	1	3	9
+7990	PF08158	NUC130_3NT		NUC130/3NT domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in a novel nucleolar protein family [1].	25.10	25.10	25.60	25.80	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.34	0.72	-3.68	29	303	2009-01-15 18:05:59	2005-02-22 16:10:13	7	7	261	0	217	296	4	51.70	41	7.26	CHANGED	FlupVusCYPc..psssFPppLt-LLppa+s....sLss-LRtpllpuLlLLRNKs.lI	......FlAp.VupCYPc......phssFPpcLt-LLppp+s...............sLcP-LR.plspuLlLLRNKslI........	0	69	113	171
+7991	PF08159	NUC153		NUC153 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This small domain is found in a a novel nucleolar family [1]. 	19.60	19.60	21.20	20.30	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.63	0.72	-7.10	0.72	-4.36	39	580	2009-01-15 18:05:59	2005-02-22 16:11:10	7	11	285	0	419	565	4	29.70	40	4.31	CHANGED	DsRFtplFEsc-FulD.os.-F+thss.spp	.DsRFp.slF-s.p-FslD.ss.cF+thpsht......	1	134	226	346
+7993	PF08161	NUC173		NUC173 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is the central domain of of novel family of hypothetical  nucleolar proteins [1].	20.20	20.20	20.30	20.40	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.21	0.71	-4.96	32	340	2009-01-15 18:05:59	2005-02-22 16:12:26	7	5	272	0	238	341	3	186.10	30	15.59	CHANGED	lschh-shL.ol+apsuhtplLplluuhF-phthp.usPhhhpsLpsluchRsspp..FshppEh-pslGuAlpuMGPEsVLshLPLNLst..ssst....pssRuWLLPlLRDplpsupLuaFpsphlPLupthpp+htc...ttsccslpsKlapTllpQlWolLPuFCshPhDLtpuF.cthAphLuslLhpps-LRssICpAL+tLl	.........................................................................................................................hphhpphL...oh+apt.shtplhpllsshFptht......h........p........u.........t..s...........hhh.phlpslschRtstp.................hshppph-p....slGuAlpuMGP-sVL..p.....hlP.Ls......ls.......tpsh........................p.sRuW....LLPlLR..-..t...l..p................s..s.....p....LuaFpsth.....lPLup......t...htp.+shc..........ht..p.s.tp....sh.psKl...a...c..o...lhtQlWslLPuFCp.h.Ph.Dlt.p.uF..p...shAchL....ush...L.c..p...s...........-LR..sslCpALppLl........................................	0	77	130	200
+7995	PF08163	NUC194		NUC194 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is domain B in the catalytic subunit of DNA-dependent protein kinases.	19.30	19.30	21.30	22.50	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.30	0.70	-5.61	8	121	2009-09-11 05:38:58	2005-02-22 16:13:54	7	15	83	0	75	118	2	341.00	37	10.01	CHANGED	sslRpuhlDRsLlTLLpHCsh-ulhpFFophIsslh-slpu+asK..ssshsa-oQllcKhusY+hlElhYuRLsK--lpScpspINpAaasSsss......cGNELTKsLhKtsasAhoEsM.sGEopLlEhR..RpYHCAAYNshlAlISCohoEhKFYpuFLFsEpsEKNpalaENLIDhcRsY...sFslElEsPhERKcKhluIR+EuR......-uupstpcpPpYLSSp.SYlsDSSLSEEhSQFDFSTGVQs..hsauop-.....ttssptutp+pEpusp........hpLEhDELNpHECMAslsuLIc.HMp+spITPps.....-cGshPt....-LPsWMKFLHsKLuNsuspLNIRLFlAKlIlNscpVF+PYA+hWluPLMQLlV....pssNsucGlHYhVVDllsTlLSWsulupPp....Gss+-El	...................................................h+.shhcRsLlsLh.pCs.sslppFF....s.p.lsphhsh.lpschs+.........sptth-...s...plhcKhu...hachl-lhYsRLsK--lpuppupINpsa.ps.s.s.hs.......cGsELT+sLlKhs.acA.............h.......o...E..sh..s......G-.spL....l..Et+..............R.YHCAAYNC..hlulIssshs-.....K....FYpuFLFs.Ecs-Ks.hlaENlID.hc+pY...sFsl.El...Esshc.c...+..c+h...l..tI.Rccsp................ct.tt..s.....p...p..tspYhu...S....s.....a.hs-SSLSEEh.o...p.F..D..Fosu.Vps..hshssps...........stssphphpcpc.tp.............................hcLEhDE.LNpHECMsshssLlp.HMp+.s......l.Pt.........pp..sshst.................................plPsWMchL+sKLss.stsslNIRLFluKlllN......sp.-VF+PYA+aWLsPLlQl.......ll..........sts..sGucGl..HYhVl-llsslL.SWsslusP.....s.................................	1	36	43	59
+7996	PF08164	TRAUB		Apoptosis-antagonizing transcription factor, C-terminal	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in traube proteins [1]. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.	20.30	20.30	20.50	20.50	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.85	0.72	-3.88	30	299	2009-01-15 18:05:59	2005-02-22 16:22:17	7	6	263	0	214	301	3	82.10	41	16.59	CHANGED	YcsLL+-Ll-p+sssuss..............t...sshhhphspppsKhKKsVDTKASKGRKlRYpVp-KLtNFM.AP.psphsWs.......-cth-ElFuoLh	.....................YppLL+-LlEp+susssss...............t...spphhthtphcsK..h+K.p.VDpK.ASKGRKlRYpVppKLhNFM.AP...spsshs.............-cshsEhFtoLh...................	0	71	115	175
+7997	PF08165	FerA		FerA (NUC095) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is central domain A in proteins of the Ferlin family [1].	22.20	22.20	22.20	23.10	20.70	22.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.86	0.72	-4.30	12	211	2009-01-15 18:05:59	2005-02-22 16:23:34	6	33	52	0	98	201	0	64.60	36	3.52	CHANGED	hulpApssssplsplhlcll-plIpDspp..LPplcsp.sssssLDhplpcLRpppLppIpEtAh+h+	...............ulpuphstpplsplhhpLlD-lIpD...spp..sLP..slctp.sssThLDpplh+LRsppLppIpEA.Ahph+...	0	18	25	51
+7998	PF08166	NUC202		NUC202 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found in a novel family of nucleolar proteins [1].	25.00	25.00	34.20	26.80	24.00	22.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.14	0.72	-4.11	4	96	2009-01-15 18:05:59	2005-02-23 09:50:55	7	4	31	0	52	81	0	70.40	48	12.27	CHANGED	PYoSsRC+..lYplL.shlhs..........C.......GtopssLQsutasoEALls..tLlpshsPP...............h.phG	......PYoosRs+..lYsl...L.hhl.s...........C.......GtptssLpsuu.suEALlT..tLhpshsPP......................s..........	0	11	14	22
+7999	PF08167	RIX1	NUC201;	rRNA processing/ribosome biogenesis	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly [1,2]. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion [3]. This family is usually associated with NUC202, Pfam:PF08166.	25.80	25.40	25.80	25.40	25.70	24.50	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.76	0.71	-4.57	37	221	2009-01-15 18:05:59	2005-02-23 09:51:27	7	9	181	0	158	213	0	166.40	23	20.46	CHANGED	h.hllssLppsptlhss...................spstlpclhs+.ltsLLpopsspsRWsGlsLl+shlpts.hplL.ppussalpsLlslLpp................spshtshphsl.slsplhphhpshPoL..oRElhTPpLssh.........Isshlslhp....................phllssLpcLlh.pHPTsFRPFsspl+shLhplls	...................................................h....ht.ltppt.lhss..........................ttstlptLhsp...lssLL..put...psR....a.tGlsLlpshlpts....h.-hh.pps.ssWlpu.lhplLpp.........................scs..s.shc..hslhsLsclh......p.hstphPsL..sR-l.s.ssp.Lssh.........lsshLs..Lhp.....................th.p...ssLpshppllh.haPssh+shtsplpshlhshl.h............................	0	41	81	124
+8000	PF08168	NUC205		NUC205 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found in a novel family of nucleolar proteins [1].	25.00	25.00	28.00	27.00	22.60	21.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.07	0.72	-4.56	4	52	2009-01-15 18:05:59	2005-02-23 09:51:41	6	1	37	0	25	55	0	44.00	54	6.46	CHANGED	EpsVhpSFossVspKFISLhSLSSDG.ClYETLIPIpsoDsEcNQ	...EpSlhcSFTASVDpKFISLMSLSSDG.CIYETLIPIpPsDPEKNQ..	0	2	2	7
+8001	PF08169	RBB1NT		RBB1NT (NUC162) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found N terminal to the ARID/BRIGHT domain in   DNA-binding proteins of the Retinoblastoma-binding protein 1 family [1].	25.00	25.00	25.80	26.80	21.30	24.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.31	0.72	-4.05	7	171	2012-10-02 16:56:36	2005-02-23 09:51:57	6	4	73	1	86	164	0	96.30	50	8.53	CHANGED	RRLNDELLGKVVsV....psptccssWasALVVSPSCsDDloVKKDQCLVRSFtDSKFaoVARKDl+Elss.slsKu-hsh+pGhctAhhFhps+tlPcs	........R+.pDEL.LGKVVsV......st..cpc...KspWaPAL..VVu.....P.....oC..sD.-....l..s.VK...KDphLVRSFpD.uK.FaS.......VsRKDl+E.lstp......shPKs-.h.s.hK.uhppAhpFh+o+slPsp..............................	0	17	22	49
+8002	PF08170	POPLD		POPLD (NUC188) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found in POP1-like nucleolar proteins [1].	25.20	25.20	26.30	25.30	24.60	25.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.02	0.72	-4.14	31	292	2009-01-15 18:05:59	2005-02-23 09:52:11	7	8	256	0	218	296	1	95.00	31	11.29	CHANGED	sWslllPata.shshWhtL...............sph......ss+hsGL+phcQlshEpstshFPtDaPt.opuGhthpph.ppcptcpcap++P.u....KRls.applshht.............sFssDW	.............................sWslllPhta.shshWhs.l...............hhh.......ssRhuG......L+Etpp.....luhEpt.t.....shFPt.D..aPs.....ot..AGh...............thttp.ptpphppcap..R+P.u....KRss.atpls.hhs.............satssW................................	0	70	114	178
+8003	PF08171	Mad3_BUB1_II	Mad3_like; 	Mad3/BUB1 homology region 2	Mistry J, Wood V	anon	Pfam-B_113144 (release 16.0)	Domain	This domain is found in checkpoint proteins which are involved in cell division.  This region has been shown to be necessary and sufficient for the binding of MAD3 to BUB3 in Saccharomyces cerevisiae. This domain is present in BUB1 which also binds BUB3 [1].	20.90	20.90	20.90	21.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.38	0.72	-4.08	8	63	2009-01-15 18:05:59	2005-02-23 09:52:36	6	2	48	7	39	66	0	73.40	37	8.76	CHANGED	KIslF+Dsh..............ucssPVYKLIcsPG+KsEKIssNFcLLYP-scc......EaClEEILA...luRsl......Y+cppsphK...c-	............KhsIFpDph...........................spssPVYplIpssG+KPE+IssNhcLIYs-sc-......EashEElLA...lSRsl.......Y+p.ppth...pp......................	1	7	21	35
+8004	PF08172	CASP_C		CASP C terminal	Mistry J, Wood V	anon	Pfam-B_7701 (release 16.0)	Family	This domain is the C-terminal region of the CASP family of proteins.  It is a Golgi membrane protein which is thought to have a role in vesicle transport [1].	28.00	28.00	34.30	31.30	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.62	0.70	-5.35	29	261	2009-01-15 18:05:59	2005-02-23 09:53:29	7	5	207	0	179	266	3	229.80	33	35.98	CHANGED	hppLppplspsstclpctcpLst+LEsDLtplptt.shstt.ssstuhhshhspphst..........t..ph.uPsssh.s......................ssssSlLPIlosQRDRFRpRNsELEc-L.+ctppplspLcpElssL+tDNhcLYEKhRYlpSYs....................ss.sssthstss....................s.t.............................................pYpppYEppLsPhsuF+t+EppRh.hp+lus....hERhhhShsRhlLus+toRhlFhhYslsLHhlVhhhhhh.huhss.hph	..........................................................................h.tpLptclsphpsphpcpppL.t+LEpDL.plpt...h.tp......spshuh...shh.pphsps....................h..sph.uPsuuh.hst...............................................................usssulLsllouQRDRFRpRNpELEp.........El.pptppplptL..ppElssLptDNlpLYEKhRalpoYst...............................sssssth...........................s.t....................................................................................+YpptY..Epp...lsPFuuFpt+EppRt.hpplSs........................h-+hhhShsRhlLuN+huRslhhhYslhLHhLVFhhLYh.huhsp....h...............................	0	63	104	152
+8005	PF08173	YbgT_YccB		Membrane bound YbgT-like protein	Rossi R	anon	Short protein clustering	Family	This family contains a set of membrane proteins, typically 33 amino acids long.  The family has no known function, but the protein is found  in the operon CydAB in E. coli. Members have a consensus motif (MWYFXW)  which is rich in aromatic residues.  The protein forms a single membrane-spanning helix.  This family seems to be restricted to Proteobacteria [1].	26.10	26.10	26.70	26.60	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.21	0.72	-4.12	36	1086	2009-01-15 18:05:59	2005-02-23 11:52:44	6	1	889	0	151	341	16	28.00	61	71.26	CHANGED	MWYFuWILGlsLAsuhullNAhWhEhpp	MWYFAWILGsLLACuFGlIsAlhLEphp..	0	23	66	108
+8006	PF08174	Anillin	DUF1709;	Cell division protein anillin	Mistry J, Wood V	anon	Pfam-B_55293 (release 16.0)	Domain	Anillin is a protein involved in septin organisation during cell division.\	    It is an actin binding protein that is localised to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis [3].	21.50	21.50	21.80	21.90	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.89	0.71	-4.13	70	383	2009-01-15 18:05:59	2005-02-23 14:59:18	6	8	201	0	244	378	0	146.60	19	15.15	CHANGED	sspstlshs....shplshttct.......hpchF..sstc..............pppthhshh......................chs.......sshcsph..h...sp-.Gshupshlshss..hph................pshupsaplclplasp....hpppsssspppphttt............................pt....................................ssapl..Gplplplhhlsc	......................................................puplslS..sl+lPLhhc.............thF...ps.p.p.................................pphhhhhhh...................................+hu...........c.hcsph.hhs..sps....hshstlsFps.hhh......................ps.sus-F.plclElYut.h...pcptshsss.s.+.+http.........................tt.hs++.......................................................tstapl..uphpLsLt.l..............................................................	0	55	97	181
+8007	PF08175	SspO		Small acid-soluble spore protein O family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins  (SASP) O type (sspO). SspO (originally cotK) are unique to  the spores of Bacillus subtilis and are expressed only in the  forespore compartment of sporulating cells of this organism.  The sspO is the first gene in a likely operon with sspP and  transcription of this gene is primarily by RNA polymerase with  the forespore-specific sigma factor, sigma-G. Mutation deleting sspO causes the loss of the SspO from the forespore but had no  discernible effect on sporulation, spore properties or spore  germination [1].	20.60	20.60	21.70	21.10	18.20	17.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.60	0.72	-3.64	5	137	2009-01-15 18:05:59	2005-02-23 15:09:59	7	2	133	0	23	61	0	47.80	76	63.65	CHANGED	sKRKANHVhPGMNAAKSQGNGAG....YpEE.uQcPLTpAQRQNNKKRKKNQ	....................G.KRKANHsIsGMNAASAQGQGAG....YNEEFANEsLTsAERQNNKKRKKNQ..	0	3	14	17
+8008	PF08176	SspK		Small acid-soluble spore protein K family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism.  The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination [1].	25.00	25.00	28.10	27.20	17.50	15.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.32	0.72	-3.96	7	127	2009-01-15 18:05:59	2005-02-23 15:10:38	7	1	127	0	20	41	0	47.40	72	89.68	CHANGED	MRNKA+GFP...NppKF-G.EPcA+scaASKRssGohNT+PQERMRASs	MG+QAEFWSESKNNSKIDG.QPKAKSRFASKRPNGTINTHPQERMRAAN..	0	4	12	14
+8009	PF08177	SspN		Small acid-soluble spore protein N family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore protein  (SASP) N type (sspN). SspN is a 48 residues protein that is  expressed only in the forespore compartment of sporulating  Bacillus subtilis. The sspN gene is recognised equally by both  sigma-G and sigma-F. The role of SspN is still not well-defined [1].	25.00	25.00	43.90	62.50	19.40	16.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.38	0.72	-4.23	8	129	2009-01-15 18:05:59	2005-02-23 15:17:28	6	1	129	0	18	37	0	44.90	71	98.57	CHANGED	MG.N.KcspsQFsPsHLGTKPhcacuNKGKKMpDKSGcpP.VhQTKG	.......MG.NPKKNSKDFAPNHIGTQSKKAGGNKGKQMQDQTGKQPIV..DNG	0	2	10	12
+8010	PF08178	GnsAB		GnsA/GnsB family	Lee SC	anon	Short protein clustering	Family	This family consists of the GnsA/GnsB family. GnsA and GnsB  are multicopy suppressors of the secG null mutation. These  proteins participate in the synthesis of phospholipids,  suggesting the functional relationship between SecG and  membrane phospholipids. Overexpression of gnsA and gnsB causes  a remarkable increase in the unsaturated fatty acid content.  However, the gnsA-gnsB double null mutant exhibits no effect.  Both proteins are predicted to possess a helix-turn-helix  structure [1].	25.00	25.00	32.60	30.30	21.80	19.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.62	0.72	-4.31	4	459	2009-01-15 18:05:59	2005-02-23 15:20:45	6	1	376	0	7	49	0	53.40	75	71.87	CHANGED	MN.EcLK+pAEp-IusaIoKKlsELpKpTGKEVoEIcFssREpMsG...LESYcVKI	...MNIEELK+pAEsEIA-aIupKIAELpKpTGKEVSEIcFTAR.EKMTG.....LESYDVKI..........	0	3	3	5
+8011	PF08179	SspP		Small acid-soluble spore protein P family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins (SASP) P type (sspP). sspP is expressed only in the forespore compartment of the sporulating cell. sspP is also expressed under sigma-G control from the same promoter as sspO. Mutations deleting sspP causes no discernible effect on sporulation, spore properties or spore germination [1].	25.00	25.00	25.10	31.50	21.40	24.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.13	0.72	-3.76	8	120	2009-01-15 18:05:59	2005-02-23 15:21:37	7	1	120	0	20	59	0	41.10	67	92.60	CHANGED	M.sKNsuKchRpNspKGcssGQP..EPLSGSKKVKNRNHoRQKHssH	....................................+pNppptcp.p.GQP..EPLSGSHKVKNRNHSRQK+pu....	0	3	11	13
+8012	PF08180	BAGE		B melanoma antigen family	Lee SC	anon	Short protein clustering	Family	This family consists of the B melanoma antigen (BAGE) peptides.  The BAGE gene encodes a human tumour antigen that is recognised  by a cytolytic T lymphocyte. BAGE genes are expressed in melanomas,  bladder and lung carcinomas and in a few tumours of other histological  types [1].	20.60	20.60	22.50	21.70	20.50	18.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-6.93	0.72	-4.19	5	119	2009-01-15 18:05:59	2005-02-23 15:22:01	6	2	112	0	16	78	0	28.70	74	4.85	CHANGED	LIAASlWLAA.SAQALEAKLpK-DLPlLA	.LIAASLWLAA.SAQALE.....A.....KL+.EDLPlLs..	0	6	8	13
+8013	PF08181	DegQ		DegQ (SacQ) family	Lee SC	anon	Short protein clustering	Family	This family consists of the DegQ (formerly sacQ) regulatory peptides. The DegQ family of peptides control the rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis. DegQ is 46 amino acids long and activates the synthesis of degradative enzymes.  The expression of this peptide was shown to be subjected both to catabolite repression and DegS-DegU-mediated control. Thus allowing an increase in the rate of synthesis of degQ under conditions of nitrogen starvation [1].	20.90	20.90	22.00	94.60	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.27	0.72	-4.24	3	28	2009-01-15 18:05:59	2005-02-23 15:22:52	6	1	26	0	5	9	0	46.00	86	99.77	CHANGED	MEK.cIEELKQLLWRLENEIRETTDSLRNINKSIDQYDKYoY.lKIS	MEK.KLEEVKQLLFRLE.DI+ETTDSLRNINKSIDQLDKYsYAMKIS	1	1	2	3
+8014	PF08182	Pedibin		Pedibin/Hym-346 family	Lee SC	anon	Short protein clustering	Family	This family consists of the pedibin and Hym-346 signaling peptides.  These two peptides have been isolated from Hydra vulgaris and Hydra magnipapillata. Experiments have indicated that both cause a reduction in the positional value gradient, the principle patterning process governing the maintenance of form in the adult hydra. The peptides cause an increase in the rate of foot regeneration following bisection of the body column. Thus both play important signaling roles in patterning processes in cnidaria and maybe in more complex metazoans [1].	27.00	27.00	39.50	42.00	24.20	18.20	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.37	0.72	-4.45	4	5	2009-09-11 09:46:32	2005-02-23 15:23:37	6	2	3	0	3	5	0	32.20	49	8.64	CHANGED	pLptEIslLQ.hhA-GEDVscpLEpKEKtLpNhcp	pLptEIslLQ.hhA-GEDVs+ELEpKEKALuNacc	0	3	3	3
+8015	PF08183	SpoV		Stage V sporulation protein family	Lee SC	anon	Short protein clustering	Family	This family consists of the stage V sporulation (SpoV) proteins  of Bacillus subtilis which includes SpoVM. SpoVM is an small,  26 residue-long protein that is produced in the mother cell chamber  of the sporangium during the process of sporulation in B. subtilis.  SpoVM forms an amphipathic alpha-helix and is recruited to the polar  septum shortly after the sporangium undergoes asymmetric division.  The function of SpoVM depends on proper subcellular localisation [1].	20.60	20.60	21.40	22.90	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-6.70	0.72	-4.18	3	45	2009-01-15 18:05:59	2005-02-23 15:24:02	6	1	44	0	19	38	0	25.90	67	15.99	CHANGED	MKFYTIKLP+FVGGlV+slLGSFKKD	..MKFYTIKLPKFLGGlVRAhLsSF+K.t	0	6	12	15
+8016	PF08184	Cuticle_2		Cuticle protein 7 isoform family	Lee SC	anon	Short protein clustering	Family	This family consists of cuticle protein 7 isoforms that are  isolated from the carapace cuticle of a juvenile horseshoe crab, Limulus polyphemus. There are 3 isoforms of cuticle  protein 7. The 3 isoforms are N-terminally blocked but could  be deblocked by treatment with pyroglutaminase, showing that  the N-terminal residue is a pyroglutamine residue [1]. 	25.00	25.00	139.70	139.60	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-4.17	3	3	2009-01-15 18:05:59	2005-02-23 15:24:28	6	1	1	0	0	3	0	59.00	95	100.00	CHANGED	QAVRYANGYTYDIETGQVSSPYTGRVYETKGKAPFYGFGFEHPYHYYPGYYHGYPHAFY	QAVRYANGYTYDIETGQVSSPYTGRVYETKGKAPFYGFGFEHPYHYYPGYYHGYPHAFY	0	0	0	0
+8018	PF08186	Wound_ind		Wound-inducible basic protein family	Lee SC	anon	Short protein clustering	Family	This family consists of the wound-inducible basic proteins  from plants. The metabolic activities of plants are  dramatically altered upon mechanical injury or pathogen  attack. A large number of proteins accumulates at wound or  infection sites, such as the wound-inducible basic proteins.  These proteins are small, 47 amino acids in length, has no  signal peptides and are hydrophilic and basic [1].	25.00	25.00	27.00	25.90	23.20	20.20	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.25	0.72	-4.05	4	21	2009-01-15 18:05:59	2005-02-23 15:25:19	6	5	16	\N	13	22	0	43.50	66	43.31	CHANGED	MIY-ssSuLFRSFL.ppupssDKRppEsp+.pt.t.KASsNKP...VMsE	..........MIYDVNSPLFRSFLSQKG.u.uuDKRKhEEpKPK-Q+.KAsENKP...VMsE.......	0	3	10	12
+8019	PF08187	Tetradecapep		Myoactive tetradecapeptides family	Lee SC	anon	Short protein clustering	Family	This family consists of myoactive tetradecapeptides that are  isolated from the gut of earthworms, Eisenia foetida and  Pheretima vitata. These peptides were termed ETP and PTP  respectively. Both peptides showed a potent excitatory action  on spontaneous contractions of the anterior gut. These peptides  show similarity to Molluscan tetradecapeptides and arthropodan  tridecapeptides [1].	25.00	25.00	37.80	37.80	17.60	15.60	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.49	0.74	-6.07	0.74	-3.72	2	2	2009-09-11 09:59:55	2005-02-23 15:25:42	6	1	2	0	0	2	0	14.00	86	100.00	CHANGED	GF+DGuADRISHGF	GF+DGuADRISHGF	0	0	0	0
+8020	PF08188	Protamine_3		Spermatozal protamine family	Lee SC	anon	Short protein clustering	Family	This family consists of the spermatozal protamines.  Spermatozal protamines play an important role in remodelling of the sperm chromatin during mammalian spermiogenesis. Nuclear elongation and chromatin condensation are concomitant with modifications in the basic protein complement associated with DNA.  Somatic histones are initially replaced by testis -specific histone variants, then by transitional proteins, and ultimately by protamines [1].	25.00	25.00	112.10	112.00	22.80	17.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.72	0.72	-3.98	2	2	2009-01-15 18:05:59	2005-02-23 15:26:42	6	1	1	0	0	2	0	48.00	98	100.00	CHANGED	ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKtHGFLKQPPRFRP	ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKtHGFLKQPPRFRP	0	0	0	0
+8021	PF08189	Meleagrin		Meleagrin/Cygnin family	Lee SC	anon	Short protein clustering	Family	This family consists of meleagrin and cygnin basic peptides that are isolated from turkey and black swan respectively. Both peptides are low in molecular weight and contains three disulphide bonds with high concentrations of aromatic residues. These peptides show similarity to transferrins and probably play some vital role in avian eggs but the exact function is still unknown [1].	25.00	25.00	30.30	30.00	17.90	15.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.34	0.72	-4.48	2	9	2009-01-15 18:05:59	2005-02-23 15:27:09	6	1	4	0	3	11	0	38.90	67	77.43	CHANGED	QVhKYCPKlGYCSSKCSKA-VWuhSsDCKhaCClPss.K	.......VLKYCPKIGYCSspCSKsplWAhSpsC.KhYCCLPAuWK	0	0	0	1
+8022	PF08190	PIH1	Nop17p; 	pre-RNA processing PIH1/Nop17	Mistry J, Wood V	anon	Pfam-B_10462 (release 16.0)	Family	This domain is involved in pre-rRNA processing [1].  It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae [1]. The C-terminal region of this family has similarity to the CS domain Pfam:PF04969.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.88	0.70	-4.99	26	646	2012-10-02 21:54:05	2005-02-23 15:49:18	7	21	191	0	432	665	8	212.10	14	58.79	CHANGED	LpD.ppc......cthcp.lpphpppps..p.hhhlpPpPGaClKTphsss.t...KsFINlCpssclstP...pppthht...stt.shpaplPhSlups+tptDpsspsCsVaDVlhNPsslppspcsptF+phlhshAhculcpca...plpLs.csh+hh.phKaKG.shpspplRtpt.tp..tt.t................................ssphttpptstplhpph................ptt...s.t..hpphssst......stpPpY..............phphhpcs......psshPcplllclcLPtlpSsppssLcluccclhl.stp................................tYhLs...l.LPYslcc-pspApFs+pp+tLplphPV	.........................................................................................................................................................................................................................................................................................hhl.Nh......h...................................................................hP....h..........p....................................................h.hshhhp..h.h.................................................h.....h.ht..ht.............t.....h...........h...........................................................................................................................................................................................................................................................................................................................................................................................s...h.hp...h.h...s........h....t...t.h.lplt.........h.h........................................h....h.hs...l.......t.......s.h....................................................................................................................................................................................	1	180	235	336
+8023	PF08191	LRR_adjacent		LRR adjacent	Mistry J, Schubert WD	anon	Pfam-B_1177 (release 16.0)	Family	These are small, all beta strand domains, structurally described for the protein Internalin (InlA) and related proteins InlB, InlE, InlH from the pathogenic bacterium Listeria monocytogenes. Their function appears to be mainly structural: They are fused to the C-terminal end of leucine-rich repeats (LRR), significantly stabilising the LRR, and forming a common rigid entity with the LRR.  They are themselves not involved in protein-protein-interactions but help to present the adjacent LRR-domain for this purpose.  These domains belong to the family of Ig-like domains in that they consist of two sandwiched beta sheets that follow the classical connectivity of Ig-domains. The beta strands in one of the sheets is, however, much smaller than in most standard Ig-like domains, making it somewhat of an outlier [1] [2] [3].	21.80	5.70	21.80	5.70	21.00	5.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.77	0.72	-4.25	29	1133	2009-01-15 18:05:59	2005-02-23 17:17:53	6	181	124	32	13	1027	3	56.90	48	9.22	CHANGED	GsllsPssIScNGsYsssslsW.s.LPs..a..hsEVSYsFsp.lplG.pspspFoGpVhQPLpp	.............GsLlsPtoISDsGoY......s..p..Ps..lsW.s...LPs..a....hNEVSYsFsQsVslG.ps.....pssFSGTVTQPL+.........................	1	11	11	11
+8024	PF08192	Peptidase_S64		Peptidase family S64	Mistry J, Rawlings N	anon	Rawlings N	Family	This family of fungal proteins is involved in the processing of membrane bound transcription factor Stp1 [1].  The processing causes the signalling domain of Stp1 to be passed to the nucleus where several permease genes are induced.  The permeases are important for uptake of amino acids, and processing of tp1 only occurs in an amino acid-rich environment.  This family is predicted to be distantly related to the trypsin family (MEROPS:S1) and to have a typical trypsin-like catalytic triad [1].	19.80	19.80	19.80	19.80	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	695	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.26	0.70	-6.19	9	71	2009-01-15 18:05:59	2005-02-24 11:40:50	6	2	57	0	45	71	3	457.00	26	72.60	CHANGED	M.hpphFuhs+tpc.t-tpsp...t-tppsps.tsss...........pso.hthcsh.ps..hospsssuspuSuh...........ascuphshssulSsh..p.ssoh.pp.....sutpsssuhhu.tsst+shpsppsSh.s..ssh.ttppssotssucspssssSp.hp.hshsEppppp..ppt..pltcpLppLtpcLshlMsplppslhNlSpAVIssI-hFKcF..............................h.oh.............psphsaplos.ssuslR+IhKIhLHFhDNLLss-sa.p.+hlLl+pa.cFhppLN.psc.......tstslsp.+saAIG..psssLPscDpltpIh-cIspss.S.lp-QsGuFIAPlLRGlopchsILslhFGhPsPpppHachlpsLasLas.DlHhhshKs.IchAusss.sss..hst...................................pph.....h.pFp.PaRlPsDs.pPPhShSlSoEsos+hSGTlGGYlYPpIs.ppps+LpuYAsupFAITCuHVsLspsp....sYPpVusPSsVL.shYKpuLtcphp+as...........-spltasuhhpplpcl...hphp....................scp+FGQllWGERolIs.......................p+LSDhAIIKVNpphcC.pNaLGDDlt.s..DPuLhFcNLYVRKh..lp+hpP..........................GhpVFKhGuTTKYT+GslNGlKLVYWhDGcIpSSEFlVsS..ssshFAuGGDSGuWILTKL-D......phGLGVlGMLHSYDGEhKQFGLFTPhs-IL-RLcpVTsIcWsl	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...................................................................hGplh....h..up+.h.p.......................tph...DhAllchs...tph.s.tNhl..Gssl....t..sPsh..hhpNh.Vpph.....l.p..hts............................Gh.pVFKhGsoTsaTsGp...lN.u...h...+...L.l...Y.Ws.......D..Gp......l..p..o....o..EF...lVsS.........sssh...............FAsuGDSGualLoKhps.............................t.uLsllGMlauhDtc.tpasl..hoPht.I.pclp.hT..................................................	0	9	24	39
+8025	PF08193	INO80_Ies4	DUF1711; 	INO80 complex subunit Ies4	Wood V, Mistry J	anon	manual	Family	The INO80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodelling complex.  This family of proteins corresponds to the fungal Ies4 subunit of INO80.	20.10	20.10	24.40	23.90	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.76	0.70	-4.41	11	94	2009-01-15 18:05:59	2005-03-04 14:12:13	6	4	91	0	75	89	3	211.90	32	78.21	CHANGED	Muuuot.ssssssRpppuus.s...........+tlVsLKLoschLpphh.........................uss.lKccpP.....S.SPuuSsst.s..sSusDNASDus.STP..ssssuuscsPpppuhPuP......KsG...sKRussts..u-ops+sRGKPGPKKKsRL........DDGT.-.......ssphsuuHRLGPKANtG............AINAGLRALDRSGpPCR+WERKslpLKSFTGl.WpLPsWRuP.s.psEpssEspp.s.pTGDSsSKsNp...ssSul.SEKSNoG	...................................................s..t.p.s.....................phhlsLplssthLpth..................................t.....s.ct.pps.....................p.oPss...sss..............sss-ssS-...us....sTP.........ss.ssss.t.tts.hssP...........KtG......sKRuhs.t..s......ts..s..........s........hs+sRGKPGP.K.KK..RL........-DGshs..........................sts.ss.ss.p+LGPKANtG............AINAGLRALDRSGKPCRKWp+pshpLKSFTGlhWplP.sWpu......P..cs.ps...ppsspppt.................sspussptp..........pttt...up................................................	0	16	38	62
+8026	PF08194	DIM		DIM protein	Rossi R	anon	Short protein clustering	Family	Drosophila immune-induced molecules (DIMs) are short proteins induced during the immune response of Drosophila. This family includes DIMs 1 to 4 that have masses below 5 kDa [1].	20.80	20.80	20.80	20.80	20.30	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.75	0.72	-4.00	7	97	2009-09-10 23:55:24	2005-03-08 14:48:02	7	1	12	0	49	82	1	35.70	50	49.37	CHANGED	MKhLol..shslhLLA.LAsAsshs..PGpVhING-C+sCN	...MKahol..shlLuLLA..LAsAssls....PGsVlINGcChsCN...	0	10	10	31
+8027	PF08195	TRI9		TRI9 protein	Rossi R	anon	Short protein clustering	Family	Putative gene of 129 bp in the Trichothecene gene cluster of Fusarium sporotrichioides and F. graminearum. Encoding a predicted protein of 43 amino acids which function is unknown [1,2].	25.00	25.00	25.10	88.00	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.42	0.72	-4.32	3	20	2009-01-15 18:05:59	2005-03-08 14:50:26	6	1	19	0	1	5	0	43.00	93	100.00	CHANGED	MLAAAKLIDSYEMDPDVSWLEVFAYSGVSAALCATIWVAAKAC	MLAAAKLIDSYEMDPDVSWLEVFAYSGVSAALCATIWVAAKAC	0	0	0	1
+8028	PF08196	UL2		UL2 protein	Rossi R	anon	Short protein clustering	Family	Orf UL2 of Human cytomegalovirus (HCMV) which is a short protein of unknown function [1]	25.00	25.00	119.90	119.80	18.90	16.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.01	0.72	-4.23	2	13	2009-01-15 18:05:59	2005-03-08 14:53:45	6	1	6	0	0	10	0	59.60	86	100.00	CHANGED	MttDuVuILIVED.s..hPSFGohsASHA.YuFRlLRGIFhlTlVlWslhWlKLLRDshh	MuEDSVuILIVEDDDDAYPSFGTLPASHAQYGFRLLRGIFLITLVIWTVVWLKLLRDALL	0	0	0	0
+8029	PF08197	TT_ORF2a		pORF2a truncated protein	Rossi R	anon	Short protein clustering	Family	Most isolated ORF2 of TT virus (TTV) encode a 49 amino acids protein  (pORF2a) because of an in-frame stop codon. ORF2s isolated from G1 TTV  encode 202 amino acids protein (pORF2ab) [1].  	22.00	22.00	24.10	28.30	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.35	0.72	-4.19	2	69	2009-01-15 18:05:59	2005-03-08 14:59:27	6	2	2	0	0	64	0	33.30	77	65.01	CHANGED	MAEFShPVRSttATEGh.pVPRAGAtGEFTHRSQGAIRARDWPGYGQGS	MAEFSTPVRStpATEGc.RVPRAGAtGEFT......................	0	0	0	0
+8030	PF08198	Thymopoietin		Thymopoietin protein	Rossi R	anon	Short protein clustering	Family	Short protein of 49 amino acid isolated from bovine spleen cells [1]. Thymopoietins (TMPOs) are a group of ubiquitously expressed nuclear proteins. They are suggested to play an important role in nuclear envelope organisation and cell cycle control [2].	25.00	25.00	25.30	36.90	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.09	0.72	-4.44	7	109	2009-01-15 18:05:59	2005-03-08 15:14:41	6	4	36	2	42	92	0	48.90	74	11.69	CHANGED	spFLEDPulLTK-KLKSELlApNVsLPsu-p+K-VYVQLYLKpLTspNp	...PEFLEDPSVLTK-KLKSELlANNVoLPuGEQRKDVYVQLYLQHLTu+N+...	0	6	10	23
+8031	PF08199	E2		Bacteriophage E2-like protein	Rossi R	anon	Short protein clustering	Family	Short conseved protein described in Lactococcus Bacteriophage c2  of 37 amino acids [1].	25.00	25.00	36.80	36.80	18.10	16.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-8.11	0.72	-4.36	2	7	2009-09-10 18:27:20	2005-03-08 15:17:58	6	1	7	0	0	4	0	31.60	89	94.44	CHANGED	ML.RLLY.RFGK.IKRRlLIDNFSNFCaYNFIs.Fh.	ML.RLLYSRFGKFIKRRlLIDNFSNFCaYNFIh.Fh.	0	0	0	0
+8032	PF08200	Phage_1_1		Bacteriophage 1.1 Protein 	Rossi R	anon	Short protein clustering	Family	Gene 1.1 in Bacteriophage T7 encodes a 42 amino acid protein, rich in basic amino acids suggesting its interaction with nucleic acids [1].  Many homologs are present in different T7 and T3-like bacteriophage.	19.90	19.90	20.40	20.40	19.00	15.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.52	0.72	-3.77	6	29	2009-01-15 18:05:59	2005-03-09 11:13:14	6	1	24	0	0	18	0	42.50	49	88.58	CHANGED	MR.NFEKhTKR.uNR.scp.F-hpEt.c+G+KhNKspRsRupKRs.WE	..............MR.NFEKhTKR.sNh.scc.hEhpEtps+h+KhpKspRspupKRp.Wc........	0	0	0	0
+8033	PF08201	BssC_TutF		BssC/TutF protein	Rossi R	anon	Short protein clustering	Family	BssC short protein (57 amino acids) has been described as the  gamma-subunit of benzylsuccinate synthase from Thauera aromatica  strain K172 [1].  TutF has been identified and described as highly similar to BssC in  T.aromatica strain T1 [2]. 	25.00	25.00	34.00	33.10	17.50	16.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.94	0.72	-4.48	4	18	2009-01-15 18:05:59	2005-03-09 15:12:35	6	1	14	0	6	17	1	57.30	53	97.91	CHANGED	M..TTCKsCuFaFuVPEsAsDaEsGKGDCVppKEDtKGKYWLSKPshcsossCtsF+.Kp	...MoTCK-Cp.FFslPEsADDaEsGKGDCVpE+cDpKGKYWLSKPlh..-su..s..sCpsFp.K.t........	0	3	4	6
+8034	PF08202	MIS13	Mis12_component;	Mis12-Mtw1 protein family	Mistry J, Wood V	anon	Pfam-B_127825  (release 16.0)	Family	Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.99	0.70	-5.35	9	220	2009-01-15 18:05:59	2005-03-15 09:49:21	6	6	165	0	141	229	2	265.80	21	60.35	CHANGED	h.Lpss.hh.pppp..htpptpspR+u.hppRGRRhS.lspth.....lssPHp-VstpEaY+plsss.Lucsh+h+QLLhWshp+ulpchc.......................h.tpsp.ss.htls+sIhcphlcDh+tsphslsW.s+c.t-c.s...........sDsplpp......p.........................................................PNspNlpNcpsls.lcpKlsplcpEhppWsphh.cspp.........sshch.tppp.ht....s+lppsp.-ssss......................splhsphEpplDpLptss+pLputs.hhs-hsspplp.+lshhhtp+hhpchcp..s.t.................ohcLLRsLo........upsp	......................................................................t.......tpttps.RRuSht.pu.RRhS............................h..Hppl..s-hh+pIssp..LsEscRhppLLhWshptultch..............................................................hh+slpcthlcshtscs..hsW.s+c.tpt.s.................................l.t.......................................................................PNspNlpspppltplp..p..plp....clptEcp...pWpthh.phpp................phch...t....t....p....tt....hp..psh.psth......................................................................tth.t..sp.l..s...phchh...lDpLttts+.Lpt......h.c.ssphh.........h.t...p.t.............................................th.........................................................................................................................................................	1	31	64	109
+8035	PF08203	RNA_polI_A14		Yeast RNA polymerase I subunit RPA14	Mistry J, Wood V	anon	manual	Family	This is a family of yeast proteins.  A14 is one of the final two subunits of Saccharomyces cerevisiae RNA polymerase I and is proposed to play a role in the recruitment of pol I to the promoter [1].	25.00	25.00	58.30	54.90	21.10	19.70	hmmbuild  --amino -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.74	0.72	-3.74	17	47	2009-01-15 18:05:59	2005-03-15 10:13:06	6	1	45	3	29	38	0	79.80	43	51.19	CHANGED	sPlsl+htus.ptlsp--s.phLscFIsppEph........s..sstt.s......ssthussssssusLuQLKRlQRDL+GL.............PPhhs	.TPlllHssph.pplop-Es.pFLppFIcppEsl...........sh.ssstss.....ss.....ssTuhshcoshooslSQLKRIQRDh+GL.............PPs..s..	0	4	14	26
+8036	PF08204	V-set_CD47		CD47 immunoglobulin-like domain	Mifsud W, Bateman A	anon	Pfam-B_2739 (release 7.5)	Domain	This family represents the CD47 leukocyte antigen V-set like Ig domain [1,2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.95	0.71	-4.38	12	126	2012-10-03 02:52:13	2005-03-18 11:48:33	6	10	67	8	29	205	0	121.20	39	39.37	CHANGED	hhlsshhss..spLhhsshhoVp.aTsCNsTVslsC.lssl.hpshsplaVcW+FpscsIhhhssspp.o.......................Lphchscsl..sGNYTCEshph.p.phcphIcLph.hhpWFo.pEp	.................................h..lt..hhh..s.llhssTKolE..aTsC..N-Tll.IPCh..ls.N.......t...sphY.l+WK...h.....c....s.....+.s......I...h...o....a....sts.p..ppoh.....hsp.a.o...S.A+l......ppL..cu..s.s.S.L.h.h.-.h..p.D.hl..sGsYTCEsht.sp..th.cohlcLp.+hssWFss.p.....................	0	3	5	9
+8037	PF08205	C2-set_2		CD80-like C2-set immunoglobulin domain 	Bateman A	anon	Pfam-B_280 (release 17.0)	Domain	These domains belong to the immunoglobulin superfamily.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-9.86	0.72	-4.08	33	3971	2012-10-03 02:52:13	2005-03-18 11:48:59	7	376	126	29	2150	9868	2	86.30	17	19.89	CHANGED	splpss..shlsst.....t.phlhpCs...ossGhPssploWhpsspsh..........hpsppppsspstlholpSpLphsssp.pspspslsCplpasshptpp	......................................................................phplsCp.....ut.s..u..p..P...s..s..p.l..p..W..h.....p..s..s.p.th............................................pp..p..p..t...p....s......p...s...s.....h...h...s....s..p..S...p.l.p..h.p....s.s.t...t...t..pst....p..l.sCps.pp.......t..............................................	0	644	828	1357
+8038	PF08206	OB_RNB		Ribonuclease B OB domain	Bateman A	anon	Pfam-B_484 (release 17.0)	Domain	This family includes the N-terminal OB domain found in ribonuclease B proteins in one or two copies.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.64	0.72	-4.46	48	5260	2012-10-03 20:18:03	2005-03-18 13:56:51	6	22	3124	6	885	5744	3246	58.60	30	10.43	CHANGED	Gplpua.ccGF.GFltsDs.....tppDlFlPtpphppshcGDpVlspltt.tccct+pcupll+l	.............Ghh.sp..ccG.F..GFl.h..s.....-s............ppDlF.....I.....P.....s.....s.....p.....h.....p.....t.....u.....h......c....G.DpVl..splpp....sc...+.c..s....c....t..cGcllcl....................................	0	278	554	744
+8039	PF08207	EFP_N		Elongation factor P (EF-P) KOW-like domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.50	0.72	-4.10	222	5745	2012-10-01 20:16:17	2005-03-18 14:02:52	7	10	4640	16	1192	3021	2037	57.00	36	30.63	CHANGED	sss-l+pGhslph.cGp.ahl.....................l-h.pasK.PGKGsAhsRsKl+NlhoG.shh-coF+u.u-pl	..............ss-h+sGhsl..ph.-.G.p...hhtV.....................l-h..pasK..PG..K.G..s..A.hsRsKl+slhoG.phlEcTF+us-ph....................	0	397	771	997
+8040	PF08208	RNA_polI_A34	RNA_polI_final; 	DNA-directed RNA polymerase I subunit RPA34.5	Mistry J, Wood V	anon	manual	Family	This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription [1].	28.10	28.10	28.10	28.10	27.30	28.00	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.40	0.71	-4.64	25	173	2009-01-15 18:05:59	2005-03-21 15:31:00	6	2	161	8	126	170	0	209.50	20	59.28	CHANGED	ptcsKplWLIpsPsslslspL.pplslsh.....sthtpup.sslptpsppYplhp-sht........tsstuptolLlssscspthhs........tshshsphapIpEssplPths.......htpshss+.shppscGL+hRahPsGhusss....................pt.stppppsppp..pptphhppscspccEppcK+pcpE.cpp......hpcKKsKKc+..........................pcp+ccKK+KK	.............p.hpscplWhIpsPsshshssl.ppltlsh......tt.tpsp...shh.stc..sp..p...Yplhpsp....................sptsphs.lLlPsppssshhh.........tshshspshplpcssplsths...............tpshss.....pssh.p.sps..L..+hRahPhGhsss....................................tt.s.sttpsppp...pptph..p.ptp....h..p.ppc..p..pc.c+pptc....ctp...................................h.tKKpKKpc.....................................................................pp...........................................................................................................................................................................................................................................................................	0	33	64	98
+8041	PF08209	Sgf11		Sgf11 (transcriptional regulation protein)	Mistry J, Wood V	anon	manual	Family	The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae.  The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation [1].	25.00	25.00	25.20	25.20	24.10	24.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.37	0.72	-4.63	33	238	2012-10-03 11:22:52	2005-03-21 16:24:55	6	7	194	4	166	251	0	32.80	46	10.50	CHANGED	ss.hhsC.NCsRpluusRFAsHL-+ChG.hupps	........spCsNCsR.tluAuRFAsHLEKChG.hGpp......	0	54	88	134
+8042	PF08210	APOBEC_N		APOBEC-like N-terminal domain	Finn RD	anon	Manual	Domain	A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes.  The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain.  RNA editing by APOBEC-1 requires homodimerisation and this  complex interacts with RNA binding proteins to from the editosome [1]  (and references therein). This family also includes the functionally  homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea  lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like  role in the adaptive immune response of jawless vertebrates [2].  Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and  prokaryotes such as Wolbachia and Pseudomonas brassicacearum [3].	38.10	38.10	43.90	43.60	32.50	31.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.61	0.71	-4.67	22	683	2012-10-02 00:10:39	2005-03-22 09:56:53	6	6	111	12	182	716	0	172.70	33	80.64	CHANGED	hphth+ts.hsp..................................tcppohlhhhlctpt......hh+Ghhpscs.....tttHsEphhlptlhshh................pssphaplshasShSPChc..................CActluphLpph.....tslslplhsp..pLa.h.pptt.................pppGlhphhpu...Ghplchhthp...Daphshphhs...ps-...............................cthphWpstp.shthhppp.hth.p	..............................................................................................................s+pcoaLCYpVctppsst........hsh.pGhhps..p...................ttpH.AEhpFLphhpshp................sssppYcVTWahSWSPChs..................CApclscFLppp.....sploLpIFsu..RLYah..ctp...............................hpcGLRpLpps....GspltlMshp...-FpaCWcsFV...ppt.......................................csFpPWcsLppp...............h...................................................	0	17	27	55
+8043	PF08211	dCMP_cyt_deam_2		Cytidine and deoxycytidylate deaminase zinc-binding region 	Finn RD	anon	Pfam-B_8221 (release 16.0)	Family	\N	20.90	20.90	20.90	20.90	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.54	0.71	-4.12	18	900	2012-10-02 00:10:39	2005-03-22 09:57:04	6	6	846	12	148	2195	501	122.40	54	42.26	CHANGED	LppYLP-uFGPpDLtl.....sshLh-ppspshslpssDs...............LhppALcAANpSaAPYScs.SGVALhspsGclYsGtYAENAAFNPSLsPlQuALlphshs..GcsassIppAVLVE+psuplSphusupsh	..........................................................Lc-YLPDAFGPKDLpI........coLL.MD.cpD....H.G...asL..s.u..Ds............................................................LsQAAlsA.A.N.+S.HhPYS+.S.P.SGVALE....s.............+.....D..G...+....I...F.......oGuYAENAAFNPoLPPLQuALh.hLsLp.......G.h...-.a..s...D..IpR.AV.....LsE+uc.A.sL.QhssTp..s...................................	0	35	71	109
+8044	PF08212	Lipocalin_2		Lipocalin-like domain	Bateman A	anon	Pfam-B_2479 (Release 17.0)	Domain	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The structure is an eight-stranded beta barrel.	21.10	21.10	21.10	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.83	0.71	-4.40	19	1931	2012-10-03 08:47:39	2005-03-23 14:57:04	7	16	1379	7	485	1577	247	138.30	39	74.08	CHANGED	lD.LpRYhGpWYElARhPhhFp.+ssscspApYsLp-DG.pIpVtNcChp..hcG...phppspGpAphtssup.su+L+VpFhs.........spu-YaVlhlDs-.YphAlVGsPsRcYLWlLSRoPplscpphppllscA+pp.GYDsscLhhssp	..........................................................................hDhpR.Y.l.Gp.WYE..I........A...R......h....s...p....p..F....E.....+...G...h....p.p....l..o.As.....Yo.L...c...s.....D.G.....s.....l.pVl..N....+shs..........ct..............hpp.s...c.G....c.....Ah.h..s...sss.......s..............putL..K..........Vo.Fas........................shhG.sY.Vlt.....L...........D..........p.....-.......Y.......p.....a.......A.......l......V..........s.........u.......P........s......+.......c..........Y..........L..W....ILSRo.Ps..l.sc...p..h....hp.p.h.ls.hAppp..G.a.D..sscllhs.....................................................	0	154	272	396
+8045	PF08213	DUF1713		Mitochondrial domain of unknown function (DUF1713)	Mistry J, Wood V	anon	manual	Domain	This domain is found at the C terminal end of mitochondrial proteins of unknown function.	20.10	20.10	20.10	20.10	17.90	19.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.94	0.72	-4.34	23	504	2009-01-15 18:05:59	2005-03-29 14:01:14	6	5	475	0	231	276	2	32.90	55	24.09	CHANGED	pspSVhR+RRpKMpKHKaKKLpK+pRsLRR+Lc+	...hsSVlKKRRK+MsK+K+RKLl++TRhpRR+htc..........	0	74	139	193
+8046	PF08214	KAT11	DUF1714; RTT109; 	Histone acetylation protein	Mistry J, Wood V	anon	manual	Domain	Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation.  Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin [1]. KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast [1].  This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11 [3].	20.30	20.30	21.30	20.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.36	0.70	-5.37	34	515	2009-01-15 18:05:59	2005-03-29 14:08:11	6	56	258	9	340	491	6	297.80	30	21.94	CHANGED	LsshLtch..lPpstplsIRhluSssppspsh.sh.st..t....psphsa+pcthhshpphss.......................-lslFGlcV..Yso............sspRplalShhDSstah+............thcstshpphlluYL..s+pcsaspth................................................................................hhuh.sptuspYlF...PsspcsPc...........scpLhcWah+hL-phl.....................................pstlllssp-hacphthhsspsp..s.............................................................stsplPhFssD.hsphL--LhcE............................lpp.h-phthRpEhphuthsu.hhh......................ts......t.hppt..h+tshptht.....tshsssspts.pplhsc......lhpphp.tp..hhhlphptssptsspshhs	..........................................................................................p..hstst...plh...lRhlt.sssp.ps..cst.thht...t..h..p..pt...hspphs..Y+s+s...lhs.Fpc...l-G..............................s-VshFGh.aVpEYs.otss...........sNpRpVYlS..YLDSlpah+Pp......................thRT.tlY+.ElLl.u.YLc.a..s+p.h..G.a...spsa................................................................................IW.A.C.PP.p.cG..DDYIFa.sHPssQKhPK....................................sc+LpcWYp+hL-+uh......................................................................................tctllhsh......p.-hac.p.........sppcths.......................................................................................................ssppl.PaF-sDhasphlE-.lcE..........................................................................................lcp..-pht..hpp...p.t..s...t....s.th.................................................................................pt...pt....p...................p.p...t....t......h........................................s..........................................................................................................................................................	0	96	158	280
+8048	PF08216	CTNNBL	DUF1716;	Catenin-beta-like, Arm-motif containing nuclear	Mistry J, Wood V	anon	Pfam-B_13045 (release 16.0)	Domain	CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain (Swiss:Q8WYA6) is thought to have a role in apoptosis [1]. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners [2,3].	20.50	20.50	20.50	25.10	20.40	18.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.19	0.72	-4.46	12	275	2009-09-11 07:46:25	2005-03-29 14:47:21	6	9	226	0	202	271	0	104.80	41	19.23	CHANGED	u-ccclslhchh-pstps.....EsLD-sslKKhlLsFEKRhhcNpEhRlKaPDsPEKFh-SElDLcchIpch+slAshP-LY..hV-LssVpSLlsLLuH-NoDIslsVl	........................t....t.phhphl-pptptt.......EslDtssl++hlLsFEK+hhKNtEhRhKasDsPpK..FM-SElDLcstIpphp....llAs.tP.-.....L.Y..hV.cL..s.sls.....SLluLL.u...H-NT.DIulssl..................	1	77	112	164
+8049	PF08217	DUF1712		Fungal domain of unknown function (DUF1712)	Mistry J, Wood V	anon	manual	Family	The function of this family of proteins is unknown.	18.20	18.20	18.30	18.80	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	604	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-13.03	0.70	-6.27	14	421	2009-01-15 18:05:59	2005-03-29 15:31:36	6	7	235	0	288	406	0	245.80	15	61.02	CHANGED	hhlFsss..hGppEGp..EhcKlLhaHP.......phslspKlpsIGlsEullpFTcsFossc.sCcs.....lcsp+pshlhhcsEssaWhshslp....p.csK-h.t.h..........hhpshL+psYphFphhpGshpuhhp.....t.scptLpshLp-ahhsah..pplp.hspp-hhc.hsol.................................QhLsLs+psaLplp................................uhlss....hssshsslt.hSshLap-pllhus.lusc-......................................................tphLasaslshhhshss.s-sus..hhpso.uhhh..sps..............h..hohsptsssspsph......................hsplal..............phcpppc.htlLhaphps.lslhlhhss.phhspp-hhpcLctplhpshoplhpslt.plsppts.st.tpcspsa..........+Ylh...hsptshth+ool.thhst.sp.s.tls.ssLcll...........................................s-lssttptu..p.tstttstEhh......................................................l+shsssWllt+psst+challLcph...................usol....l-lscplt+hsspah.sshF	............................................................................................p.....t........tplhhah...............................t....php.lGh.puhhthsp...h...s.t....t....p...........................lp..pp.p....hh.p.E..tha.h.....h.lp....................................................................h.t.l...hthahh..s...................................h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	100	149	222
+8050	PF08218	Citrate_ly_lig		Citrate lyase ligase C-terminal domain	Bateman A	anon	Pfam-B_3588 (release 16.0)	Domain	This family is composed of the C-terminal domain of citrate lyase ligase EC:6.2.1.22.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.12	0.71	-4.82	14	1051	2012-10-02 18:00:56	2005-04-01 14:24:12	6	8	898	0	105	1842	244	182.00	56	52.98	CHANGED	luuIVMNANPFTLGHpYLlEpAuppsDalHLFlVs-DsShFsap-RhsLlppGspcLsNlslHsGucYlISpATFPuYFlK-ps..sVhcspsplDlplF+chIApsLsIT+RYVGpEPhsplTshYNQtMpphLtpst.....Ipll.ltRp..ptsspsISASpVRphlccsshptltpLVPtTThpYl	...............................................IGsIVMNANPFThGHRYLlpQAAupC...D..W..LH..L..F..l..V....+...E...D....s..S....h.....F.s.Y..cDRhsLVhcGs.A..c..l...s...p...lTVH.p.G.S....-...YI....I...S...R...A...T...F..P..s..Y..Fl..KEpu..llsc..saspID..LpIFRpalAPALG.......I.THRFVG.oE.......P.......FCpVTspYN.QsM+hh.Lc.sss.s.ussIclVEItRl...........phpptsISAS+VRpLLscp....-.h.s.........AIusLVPssTLpYL.............................................................................................	1	27	54	77
+8051	PF08219	TOM13		Outer membrane protein TOM13	Mistry J, Wood V	anon	manual	Domain	The TOM13 family of proteins are mitochondrial outer membrane proteins that mediate the assembly of beta-barrel proteins [1].	25.00	25.00	36.80	35.60	17.50	16.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.75	0.72	-4.22	16	121	2009-01-15 18:05:59	2005-04-01 16:42:45	6	2	120	0	92	112	0	81.80	45	43.57	CHANGED	lshssDuEststhppps.s.pssusssh......slWull+uuuINLlLPFlNGhMLGFGELlAHEluFRasW......sGs+l.P.pRh	................................................................l...s-SEphs...s.pp...s...sssss..ssssh......................olaull+uuAINLlLPFlNGhMLGFGELhAHE.h.uFRh.GW.......sGsKlaP.pR+.................	0	22	47	77
+8052	PF08220	HTH_DeoR		DeoR-like helix-turn-helix domain	Bateman A	anon	Bateman A	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.51	0.72	-4.43	15	15183	2012-10-04 14:01:12	2005-04-05 17:40:47	7	49	3318	0	2086	11826	840	55.70	33	21.64	CHANGED	RpppIlchlpppGplolcELspthsVSstTlRRDLscLpppGl.lpRsHGGAthsssp	...........................RpptIl.p.h.l.....p..p..p...s..t..l..s.l..p.....-..L.u.p..t.....h..s.V..Sp...tTIRRDLs........p....L..pp.....pG....h....l...p...R...s....+G.GAhh...............................	0	573	1175	1649
+8053	PF08221	HTH_9		RNA polymerase III subunit RPC82 helix-turn-helix domain	Moxon SJ, Bateman A	anon	Pfam-B_9884 (release 8.0)	Domain	This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa [1]. This region is a probably DNA-binding helix-turn-helix.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.67	0.72	-4.10	18	285	2012-10-04 14:01:12	2005-04-05 17:50:21	6	11	249	2	200	310	6	60.60	30	11.07	CHANGED	pLsstllcpaaG-lsupVsstLlppGpholpplscpsp..LshspV+puLssLlQaphVpYhtp	.......................LsshllpppFG-l...ssclhstL.lp.p.G...p.s....lppls..p............pop.....ls....hc.pV+puLslLlQpslV.a.............................	0	63	106	160
+8054	PF08222	HTH_CodY		CodY helix-turn-helix domain	Moxon SJ	anon	Pfam-B_7573 (release 9.0)	Domain	This family consists of the C-terminal helix-turn-helix domain found in several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.02	0.72	-4.63	3	1097	2012-10-04 14:01:12	2005-04-05 17:50:46	6	4	1087	3	131	519	14	60.70	76	23.39	CHANGED	pEGRLTASsIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLN-pFl+ELcchK	...........EGhLsASpIADRlGITRSVIVNALRKLESAGlIE.S.R....SLGMKG.TYlKVL.ps.chh-ELcK.........................................	0	59	91	113
+8055	PF08223	PaaX_C		PaaX-like protein C-terminal domain	Fenech M	anon	Pfam-B_9563 (release 14.0)	Family	This family contains proteins that are similar to the product  of the paaX gene of Escherichia coli (Swiss:P76086). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid [1]. 	21.00	21.00	21.10	21.10	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.97	0.71	-4.57	63	785	2009-11-26 12:00:55	2005-04-06 08:39:11	6	3	636	5	203	603	67	159.20	26	55.33	CHANGED	tsW.......cGpWpllhh...sptptptRcplRcpLphhGFGplusulalpPsshtt...slpthltchshpsps..hhpsh......s....shpphlppsWsLsplsptYcpFlppapshh...............tptpt..hsstpsahtRhLLlHpaR+hLlpDPhLPpcLLPscWsGtsARpLhpslappltss	.....................................................................................tWcGpWhLllh...sthcpss+tpl+cp.....LthhGFGsLt....sulahpPsphtt.......................slpp.h...lt...c...h...sls...s...pl...hhhpup.....hsps.........shpshlp.....phWc...LsphsttYcp....Flppapshh...............ttttp....hsstps.hhhphlLl..ct...aRRhlhpDPh.LPt-LLPscWsGtpA.Rphhhshhpplt..h................................................................	0	55	122	166
+8056	PF08224	DUF1719		Domain of unknown function (DUF1719)	Mistry J, Myung-il K	anon	Pfam-B_27966 (release 16.0)	Domain	This is a domain of unknown function.  It may have a role in ATPase activation.	25.00	25.00	29.10	26.60	23.20	22.70	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.27	7	104	2009-01-15 18:05:59	2005-04-07 11:11:33	6	3	7	0	74	84	0	200.20	37	46.05	CHANGED	+pSuFPRRIAHATKShlSS.lhhsshDt.sopSsVRRFEhhADGAs-FLR.VEhGGo..P+pYhFFDPLIuHLLAGcsLcYchlp.Gsp.+hhhIRPhshtERGlEAhlhFshpsspsPccsFhLGhlLplSESTsllGhlI+CLQ.hhsPHF+SssEsV+pELsQLPTQDhoWl.sas..hc.haWDslHshtTpWaRPNPlCCppHs....t..toushshhtl.sh..psVIpl.lppal	............................psuFP+RlA...+As+ShlSS..hh..t.......t...s.-...p....op.............osVpRFEhFADGAs-FLRhl.E.h..Gus..spp..a.......h.h..hDPLlt+L.LAGctLpYc.h.hp....G....sp..............h.hh.hl..t..P.......h..s.ht-RGl....EAtlhhhhpDt..pts-psFhLshhLplSE.STsllGhhlpCLp...hhs...P..pFc..s.ssEss....+pcLspL.ppch...hh..P....h..........p......ahppl....Hph.ophhRPsPhCCcp.pp.........t...........t...t...t...t...t......th...EslIpl.hpt................................	0	0	36	58
+8057	PF08225	Antimicrobial19		Pseudin antimicrobial peptide	Rossi R	anon	Short protein clustering	Family	Pseudins are a subfamily of the FSAP family (Frog Secreted Active Peptides) extracted from the skin of the paradoxical frog Pseudis paradoxa (Pseudidae).  The pseudins belong to the class of cationic, amphipathic-helical antimicrobial peptides [1].	19.40	19.40	21.20	56.60	19.10	17.10	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.45	0.72	-6.81	0.72	-4.47	2	4	2009-01-15 18:05:59	2005-04-08 11:48:24	6	1	1	0	0	4	0	23.00	78	97.87	CHANGED	GlNTLKKVhQGLHEsIKLlsNHs	GlNTLKKVhQGLHEsIKLlsNHs.	0	0	0	0
+8058	PF08226	DUF1720		Domain of unknown function (DUF1720)	Mistry J, Wood V	anon	Pfam-B_19709 (release 16.0)	Domain	This domain is found in different combinations with cortical patch components EF hand, SH3 and ENTH and is therefore likely to be involved in cytoskeletal processes.  This family contains many hypothetical proteins.	21.40	21.40	21.40	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.26	0.72	-11.42	0.72	-3.92	66	116	2009-01-15 18:05:59	2005-04-13 14:45:25	6	24	75	0	89	133	0	78.20	31	8.31	CHANGED	hQP...............................QtTG............................pts..........sl.....psQsTG............hpP....................Q.TGh........................lpP....QtTGh..............................................t......h.pPQsT..............Ga	..................................................................s.ttp.....tlpsQ....TG...........hpP..........Q.TGa.....s.tt.....................LpPQpTGF........................t.h.pPQ.TG............................................	0	28	53	79
+8059	PF08227	DASH_Hsk3	DUF1721; 	DASH complex subunit Hsk3 like	Mistry J, Wood V, Finn RD	anon	manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.	24.00	24.00	24.70	28.90	23.50	23.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.82	0.72	-3.77	16	165	2009-01-15 18:05:59	2005-04-13 16:15:21	6	2	133	0	96	142	0	45.60	43	20.17	CHANGED	pRphupLtuQLspLpsNLuchpphLchsuhQs..pshctLGshpuuh	...sRphspLhhp.ptLstNlAphsp.LchhSlQs..hc.+FLuuhshu......	0	16	37	68
+8060	PF08228	RNase_P_pop3		RNase P subunit Pop3	Mistry J, Wood V	anon	manual	Family	This family of fungal proteins form a subunit of RNase P, the ribonucleoprotein enzyme that cleaves the leader sequence of precursor tRNAs to generate mature tRNAs.\	  The structure of Pop3 has been assigned the L7Ae/L30e fold [1].\	This RNA-binding fold is also present in human RNase P subunit Rpp38, raising the possibility that Pop3p and Rpp38 are functional homologs.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.02	0.71	-4.40	5	88	2012-10-10 14:40:03	2005-04-14 09:40:32	6	1	88	0	67	163	1	156.70	25	65.50	CHANGED	KR+QVYKPVL-NPaTNEAchWP+Vc-Q.lllELLpspll+sLl+hpc...Kss.-pclssGaNEIl-lLu..pusSc-V.....hLFVCs+D...PSVLloQlPLLstsushs....VsLVQLP+uupA+Fc-+l.GhS+s...GMLLV+ccAslDpsFsshlpspVEphshPWLcs	........................................................................................................................................................................................................................................p....l............hhu......hNplsphLp........ptss..p.h.................................hlFVs+pD..p.P.sl..LhpphPhLsh.h....Asts......................l+LVtLPKuu.splussL..Gl.s+s.....uhlulp..s.ss.s.hs.ps.LhchlpppVs.....l....p..hPWLp.........................................................	0	18	38	58
+8061	PF08229	SHR3_chaperone		ER membrane protein SH3 	Mistry J, Wood V	anon	manual	Domain	This family of proteins are membrane localised chaperones that are required for correct plasma membrane localisation of amino acid permeases (AAPs) [1].  SH3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of SH3, AAPs are retained in the ER.	25.00	25.00	46.70	38.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.15	0.71	-5.35	17	149	2009-09-11 11:37:31	2005-04-14 11:25:11	6	2	130	0	110	144	0	193.30	34	90.31	CHANGED	Yp-hssluTuL.IlsuToFhLGllFushPYDashLWssssT.tptFDhuLpHYphhtsoP.hlhalLahVhhLGllGthIKLYKPst-spLF-YuSLsLYhlulslYlTNl+pGlpsshsGsWG.................-VspppGlsVlAASplhlhllLlGVLlLQuGhWYApac-ppphcpFhpcE.....tttttptppptcsppppspppK	...................................sshuThl.IlssosFhLGllFupaPYDaslLWsssso..ssa.........a.-hh.pHhp.h.las.......o.....Ps...hl.tlLpl...VhhlGllGhhhKLa.KP....sEushhFDGuSLsLYhhulsVY.lsNlhpGlcssss..staG..........................................................l..scps...u....LpV..l..AASNsIlsllLlGVLlLQuGpWY.Acpc-ppchcph.tcc.........tpttttttt...................pt.............................	0	35	64	95
+8062	PF08230	Cpl-7		Cpl-7 lysozyme C-terminal domain	Garcia Lopez E, Bateman A	anon	Garcia Lopez E	Domain	This domain was originally found in the C-terminal moiety of the Cpl-7 lysozyme encoded by the Streptococcus pneumoniae bacteriophage Cp-7 (Swiss:P19385). It is assumed that these repeats represent cell wall binding motifs although no direct evidence has been obtained so far.	25.00	25.00	39.20	25.30	22.80	23.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.92	0.72	-4.23	14	202	2009-01-15 18:05:59	2005-04-14 13:01:08	6	31	126	0	22	178	7	40.60	50	18.33	CHANGED	lcplApEVIpGpaGNGp-R+psLt..GaDhcAVQscVNplLs	..................lDplApEVIpG..caGNGp-R+p+L...GhsYssVQp+VNchL.....	0	8	8	13
+8063	PF08231	SYF2		SYF2 splicing factor	Mistry J, Wood V	anon	Pfam-B_11988 (release 17.0)	Domain	Proteins in this family are involved in cell cycle progression and pre-mRNA splicing [1] [2].	22.40	22.40	22.80	24.20	20.70	22.30	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.22	0.71	-4.09	26	339	2009-01-15 18:05:59	2005-04-14 14:01:54	7	5	283	0	231	317	2	149.80	35	56.19	CHANGED	cppGhDh-Rp+.hhshospcsEchcc+ccKKcpp..s.uassaspps.h+tYc+ph+sh..phDh-pYc+pKcphsct.............................FYsssssh..s.....pppPsp-A.l-+llpslc+pp....................cpRpKhpR+Rttc--t...DlsYIN-RN+pFNcKLsRaYsKYTsEI+pNLE	......................................................................t.ttGpDh.-+h+.hhchos--uE+..a-+Khc+Kptc...hGFs.sYsp.ts...h....+tYc+hh+pl........psDhEpY..c+p+ppt.s-t..........................................Fassus...o..lh..au...ppt..s.s.pcs..lDRhVp-Lccp.....................c+...RtKhpRR.Rhhs..--s.....Dl..s.YI.NE+NpcFNcK....lpRaYsKYTtEI+pslE..........	0	79	127	188
+8064	PF08232	Striatin		Striatin family	Mistry J, Wood V	anon	Pfam-B_7946 (release 17.0)	Family	Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (Pfam:PF00400) repeat domain [1]. It acts as a scaffold protein [2] and is involved in signalling pathways [1] [3].	27.00	27.00	27.30	32.00	26.70	26.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.79	0.71	-3.85	31	401	2009-01-15 18:05:59	2005-04-14 16:11:00	7	11	230	0	232	376	0	125.40	42	18.23	CHANGED	TLsGVh+aLQoEWp+hER-RstWElERuEM+uRIApLEGEp+s.cthppcLt++lchLEhslKpcRs+hpp............................................tt..t.tt..t.t.tsst.sp.stpspsphpcuR.hLpcshpElsY..hllss..s	.........olsGlh+alQpEWsRaEh-RspWElERAEhp.............A+IAhLpGER+upEs.LKpDL..sRRIKMLEaALKQE..R.AKh++L+hGs-hs........................................................................................ptp...........p..ps....tsp.p.t.st.......ttssphth+puRphL+........Q..a..LpElGY..pIlssp.s............................................................................................................	0	64	103	170
+8066	PF08234	Spindle_Spc25		Chromosome segregation protein Spc25	Mistry J, Wood V	anon	Pfam-B_14484 (release 16.0)	Family	This is a family of chromosome segregation proteins.  It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex [1], and in vertebrates it forms part of the Ndc80 complex [2].	22.30	22.30	23.60	22.30	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.27	0.72	-3.98	58	256	2009-09-23 13:20:45	2005-04-15 13:01:43	7	7	219	2	194	247	3	73.90	28	28.58	CHANGED	lcshts-p..l+FhFspl-sp-.p+E..hthslp.lss..ppYclhpssPpl...pslscllpcLN....cspshhtFl+phRctFtp	...........................hchhtt-p.LcFlFsp..lD.ps.-+c..hhFpLs..lsp.....ccYclhcspPpL....pslpcllcclN.......copshssFL+phRctFht............	0	62	110	157
+8067	PF08235	LNS2		LNS2 (Lipin/Ned1/Smp2)	Mistry J, Wood V	anon	Pfam-B_2646 (release 16.0)	Domain	This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins [1].  SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration [2], and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain [4].  Lipin proteins are involved in adipose tissue development and insulin resistance [3].	26.70	26.70	27.50	26.90	26.30	26.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.75	0.71	-4.66	16	814	2012-10-03 04:19:28	2005-04-15 14:14:50	8	20	307	0	473	726	11	147.40	44	17.04	CHANGED	VVlSDIDGTIT+SDsLGHhlshhG+D.Wo+sGlscLapclppNGYpIlYlTuRulGQAcpT+uYLppl.pts..pLPcGPllLSPsthhsuhhRElIh++PchFKhusLp-IpsLa............sppPFaAGFGN+.sDshuYpsVGlPssRIFhlNspGElhhp	...............................lVlSDIDGTIT..+SD..s......L.Gpl.l...........s...h...lG+..D....Wo..+.........tGlscLa.p..cl............ppNGY.phlYlouRul.uQAchT+uaLptl.p..t....s...............h....t...............LPcGPl.hhSPsphhsu.hp..REll..p+..cPc.tFK..hssL.p.........DIpsLF.............................................pppPFYAuFGNR.sDlhu..Yp..............pVGlP...s+IFhlsspuclh.............................................	0	132	208	346
+8068	PF08236	SRI		SRI (Set2 Rpb1 interacting) domain	Mistry J, Wood V, Sammut SJ, Bateman A	anon	Pfam-B_106465 (release 17.0) & pdb_2a7o	Domain	The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation [1].  This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilises the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation [2].	20.90	20.90	20.90	21.90	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.96	0.72	-4.04	25	233	2009-01-15 18:05:59	2005-04-15 16:03:34	6	10	207	2	167	246	1	90.50	28	7.69	CHANGED	psspphccpacp..hlupaVsNhlcKYccc.......ls+-shKphA+-ls+tLssKEhK.......pss...spsPstEloccpp+KlKpFs+pYMDKhltKhcp+c	..............t.tc+pcchacp..phutalsphlsta++p.......hscE-...hK+.h.A+cls+tlssK.E.hK.......psc......ss.shcls-......phc+KlKcalKcYhpKhssha+t.........	0	52	85	132
+8069	PF08237	PE-PPE		PE-PPE domain	Mistry J, Adindla S	anon	manual	Domain	This domain is found C terminal to the PE (Pfam:PF00934) and PPE (Pfam:PF00823) domains.  The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.41	0.70	-4.93	32	715	2012-10-03 11:45:05	2005-04-19 14:46:55	6	11	138	0	135	708	1	213.70	31	45.55	CHANGED	P..shs...h.hl...hPt........thh......hssh..........ohspSlutGsstLpsAlpst...................ssss...hslhGaSQGAhlsst.htpLts..ssss....ssloFlhlGsPtps....sGGlhspass..hhlPh.....tlsassssPsss.........Ys....ThplstpYDuh.ADhPshPhNllAssNAlh.......G.hhhlH.........s.......sa.s...........s..s.....stshs.s.spstsusTTYhhlPsp..pLPLL.PL+.l.s.......lssslsshl-ssL+slV-tGYs	..................................................................psl...hPt....................phhPhss.......lssh....................ohs..pSV.spGs.s..Lc.sAI..t...s...t......................ssss...lsV...h...GaSQuAhlsshthpp..Lts...s.ssss.........................sspL.s.F.l.h.lGsPtpP..............sGG..lhtpas......s.............hh....lPh....................l.s..assssPsss......................Ys..........T.h.hsh.pYDGh.uD...h...Pp...h...P...h...Nl.l.....u.s.h.NAlh...........G..hhh..sH............s...........sa..shs......................................................stt...........stsl.hs..ss..uhs...usTs.YYhl.sp..pLPLL.PLRtl..s...............lsss...lsshlpssL+slls.hGY.......................................................................................................................................	0	19	73	122
+8070	PF08238	Sel1		Sel1 repeat	Bateman A	anon	Pfam-B_49 (Release 17.0)	Repeat	This short repeat is found in the Sel1 protein [1].  It is related to TPR repeats.	21.10	2.40	21.10	6.80	21.00	-999999.99	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.33	0.72	-3.19	594	40768	2012-10-11 20:01:00	2005-04-21 12:03:46	7	502	2506	23	13860	42646	6566	35.20	26	38.95	CHANGED	spAthpLG........h...pG...........l.p....s....hpp..AhpaappAAppGp	.......................................AthtLG..............hha.hpG.t.....................G..ltp.........D..............hpp.......Ah..paappAAptG.................................	0	6224	9270	11773
+8071	PF08239	SH3_3		Bacterial SH3 domain	Bateman A	anon	Pfam-B_178 (Release 17.0)	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.82	0.72	-3.78	263	10209	2012-10-02 18:48:24	2005-04-21 15:21:09	6	416	2914	9	1841	9471	1861	54.50	23	20.20	CHANGED	ssl..slR..ssP.sts...up..hlsp.......l..tG..pplpl....lp..ppss................W..hcl....................t.suh.p....Gal..t..sshlp	............................s..l..slR..ssP..uss...sp....llsp...................l..ppG......pp.lpl.............ls....ppss.........................................W.......hcl.......................p.sGp..p..........Gal..s...sphl...........................................	0	797	1353	1602
+8072	PF08240	ADH_N		Alcohol dehydrogenase GroES-like domain	Bateman A	anon	Pfam-B_7 (Release17.0)	Domain	This is the catalytic domain of alcohol dehydrogenases.  Many of them contain an inserted zinc binding domain. This domain  has a GroES-like structure [1-2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.71	0.72	-4.29	92	42970	2012-10-01 22:45:51	2005-04-21 15:24:04	7	521	5327	455	13369	34065	8204	101.00	25	23.28	CHANGED	ss-Vll+lpssGlCsoDl..phhpG...............hhsphP.......hlhGHEhsGhV.p..lG.ssVps......hphG-+Vsl...shhs.C........up..............Ct.Cpp.Gp..shC.........................tphphhGhs..........hsGuaAEY.lhlP.......tptlh.l	..................................................s-Vll+lp.s.sGl..s.t..s......Dl.....th..h.pG.........................................h...ht.hP..............h.l..h.G...H...E...........s.....s..G.........h..Vh..p....l...G....s...s..V.s.s..............................h.c..sG...D.........+.V..s.s.......................s...........................................s.........s.....................t............s...............................................................................................u.....t..p..h...h.............h............................................................................................................	0	3704	7884	11039
+8073	PF08241	Methyltransf_11		Methyltransferase domain	Bateman A	anon	Pfam-B_21 (release 17.0)	Domain	Members of this family are SAM dependent methyltransferases.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.13	0.72	-3.50	172	22723	2012-10-10 17:06:42	2005-04-22 12:24:16	7	278	4590	31	8318	65769	22557	94.00	22	33.45	CHANGED	LDlG...sG.sGhhsthlspt.........stplhulDhstp.......hlp......hucpphttt.....................hhtus.......sppl..Pht.-s..oFD.hl...hsttsl..pah.......pc.ppslpEhtRlL+PGGhlhh	.......................................................................................................................L-lG...sG...sG..h..h..s...h..h..htpt........................stp.l....h..u......l....D...h...stt..............................h.lp...................h.u..p..p....p..h..t..t.t.t..t............................................................hht.u..s......................s.p..p..L...........P.....a.....s.....-....s............o......F...D.....h.l.....................h..s....t.....t.....s....l........pah..........................tc..h...t...p......s...l...p.....E....h....t......R....V....L.+.P.G.Ghhh...........................................................................................	0	2885	5512	7158
+8074	PF08242	Methyltransf_12		Methyltransferase domain	Bateman A	anon	Pfam-B_46 (release 17.0)	Domain	Members of this family are SAM dependent methyltransferases.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.27	0.72	-3.52	108	3160	2012-10-10 17:06:42	2005-04-22 12:25:33	7	531	1307	4	1307	38110	12780	102.00	25	6.03	CHANGED	L-lGsGsGthhthlhpt...................thphh.uhDhSsthl.....hstpchtphph.th.thphtthshhp..............................saDl....ll...sh.sllcah.........tshp.psLp..plt.phLps.uGhl	...................................................................LElG.uG.o.G....s...s.o.t.h.ll..pth.......................................th.c.Y.s....hoD...l......S...s.shl...........ttA.p..p............+....h...s....s....h........s..............h......t......h......t......h....h.....c..h.p..p..h..s..h..t.p.t.........................................................................................tsaD.l.........l...l......us....s.....V.L.Hss......................ppl...p...psL.p....plp...pl...L.p.P.GGhl...........................................................................................	0	345	748	1069
+8075	PF08243	SPT2		SPT2 chromatin protein	Mistry J, Wood V	anon	manual	Domain	This family includes the Saccharomyces cerevisiae protein SPT2 which is a chromatin protein involved in transcriptional regulation [1].	20.90	20.90	20.90	22.10	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.95	0.71	-3.78	7	281	2009-09-11 05:41:46	2005-04-22 12:54:49	6	7	216	0	195	268	0	106.40	30	22.63	CHANGED	Kpsshsh..ptpSt+t...s.ph-s-pDpchpcFIcD-cE-psch..........pccIhpIFshs+p+....ap..D--D.....MEAshtEl.cEEpRutRhAcLEDccE.ph.cEctppK+t+Kp+	...........................................................tt.........................pcp.cc...-....D...p-h..-.D..F..I...-D-t-ppc.p.......................ppt.IhthFs.h.s+p+.......Y..p....D.-....sD.......ptMEuuat-lpcEEt+St+lutpEDhcE....hchEcccp+c.Kct+Kt.........	0	57	95	152
+8076	PF08244	Glyco_hydro_32C	glycosyl_hydro2; Glyco_hydro_32; 	Glycosyl hydrolases family 32 C terminal	Finn RD, Mistry J	anon	Prosite	Domain	This domain corresponds to the C terminal domain of glycosyl hydrolase family 32.  It forms a beta sandwich module [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.12	0.72	-3.60	178	3225	2010-01-08 16:43:10	2005-04-25 13:01:37	7	49	1933	59	570	2522	88	88.70	22	16.56	CHANGED	hcls............................ssp.....th...Gltlhht..sstpcpstlhac................t.tppplslDRspou....ts.......ht.thss......hctshhtt...................tth..........................pL+lhlDcSslElFsssG	....................................................................................................ththtt..................h......th..l.h......tst..scthtlh.ac.............................t.tps..plslDR.opuu........t....................ht.thssh................scss.hsp..............................................................pt................................pLclhlDpSslElFsNsG...............	0	129	322	462
+8077	PF08245	Mur_ligase_M		Mur ligase middle domain	Bateman A	anon	Pfam-B_26 (release 17.0)	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.40	0.71	-4.25	92	26660	2009-09-15 12:35:17	2005-04-26 11:46:18	7	94	4735	65	5962	19905	11199	195.10	21	41.78	CHANGED	lTGTNGKTTTsphltpll..ptt....st.hhsosG................s..t.lGlshhhhthtp.....tschhlhElSSa.......plpth.......hcsclu..lloNlsp-HL-..ha.toh-s.YhpuKtcla.ptht.ts......hsllN..h....DDt.....hhhthhpptthp.sl.sauhpsps...............lth..pssph...................................hh.h............hpl...slhG....p...aNltNsLAAluss	...................................loGTsGKTTTs...s..hl.splL.....pts.............Gh..ps...t.s...h.G.....................................................................s............l...s.h.s..h..h.h..h...h..htp........................tsc.h.hVh...Esu...p.t..................tplsth....................h.pP...p...lu.........l..l..TN.......l.s.h.D.Hh....-........ha....s.......s......h..-.s....ht.p.s.Ktp.....lh...c.t...h.............ts................h.s.l.ls....t.....-cs..............................hhp.h..h.....t...t..t....t...t...p......hh...t..a.u.h.p.tts....................th..t...tlt.h.........p..s.t.t.h................................................................................p.h.h..h............t...ht........hpl.......sl.G..........p......aNh....N.uhsAluh........................................................................................................................................................................	0	2011	3956	5101
+8078	PF08246	Inhibitor_I29		Cathepsin propeptide inhibitor domain (I29)	Bateman A	anon	Pfam-B_14 (release 17.0) 	Domain	This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide.  There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin Swiss:Q70SU8. This family is classified as I29 by MEROPS.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.98	0.72	-3.70	95	3417	2009-01-15 18:05:59	2005-04-26 17:20:04	7	34	536	17	1591	3509	92	58.50	30	16.86	CHANGED	FppahpcasKp..Y...............tsppE....ptpRh.phFtpNhphlppaN...........pspts.......a...ph........................................ulNcFuDhopcEa	............................appattpas+s.....Y........................tst.pE.....ctp..Rh.plFc.....cNhchIcpaN...........................tspto..............a......ph..........................................ul.N...pFuDhTp-EF........................................................................................	0	651	976	1322
+8079	PF08247	ENOD40		ENOD40 protein	Rossi R	anon	Short protein clustering	Family	Rohrig et al. reported the in vitro translation of two peptides of 12 and 24 amino acids from the short, overlapping ORFs of soybean ENOD40 mRNA [1]. The putative role of the enod40 genes has been in favour of organogenesis, such as induction of the cortical cell divisions that lead to initiation of nodule primordia, in developing lateral roots and embryonic tissues. This supports the hypothesis for a role of enod40 in lateral organ development [2].	20.40	20.40	22.70	22.70	17.80	16.30	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.84	0.74	-6.01	0.74	-3.79	4	11	2009-01-15 18:05:59	2005-05-03 16:13:00	6	1	7	0	0	9	0	12.30	76	100.00	CHANGED	McLCWQpSIHGS	...McLCWQKSIHGS	0	0	0	0
+8080	PF08248	Tryp_FSAP		Tryptophyllin-3 skin active peptide	Rossi R	anon	Short protein clustering	Family	PdT-3 or Tryptophyllin-3 peptide is a subfamily of the family Tryptophyllin and of the superfamily FSAP (Frog Skin Active Peptide).  Originally identified in skin extracts of Neotropical leaf frogs, Phyllomedusa sp. This subfamily has an average length of 13 amino acids. The pharmacological activity of the tryptophyllins remains to be established [1] but it seems that these peptides possess an action on liver protein synthesis and body weight [2].	17.70	17.70	23.10	23.10	12.50	10.90	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.28	0.74	-5.89	0.74	-3.17	2	8	2009-01-15 18:05:59	2005-05-04 09:25:07	6	1	5	0	0	8	0	12.00	75	91.43	CHANGED	EKPaaPPPIYPh	D.KPFWPPPIYPh.	0	0	0	0
+8081	PF08249	Mastoparan		Mastoparan protein	Rossi R	anon	Short protein clustering	Family	Mastoparans are a family of tetradecapeptides from wasp venom, that have been shown to directly activate GTP-binding regulatory proteins.  These peptides show selectivity among G proteins: they strongly activate Go and Gi but not Gs or Gt.  The peptide of this family are composed by 14 amino acids but they can assume different structures [1].	21.00	21.00	21.40	21.40	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.67	0.74	-6.03	0.74	-2.95	5	10	2009-01-15 18:05:59	2005-05-04 09:45:41	6	1	8	3	0	12	0	14.00	72	84.34	CHANGED	INLKAlAAlAKKlL	INLKAIAAhAKKLL	0	0	0	0
+8082	PF08250	Sperm_act_pep		Sperm-activating peptides	Rossi R	anon	Short protein clustering	Family	The sperm-activating peptides (SAPs) are isolated in egg-conditioned media (egg jelly) of sea urchins. SAPs have several effects on sea urchin spermatozoa: stimulate sperm respiration and motility through intracellular alkalinization, transient elevation of cAMP, cGMP and Ca++levels in sperm cells [1,2].	18.00	18.00	18.20	18.20	17.60	17.60	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.36	0.75	-5.62	0.75	-3.07	11	21	2009-01-15 18:05:59	2005-05-04 09:46:47	6	1	8	0	0	10	0	10.00	75	100.00	CHANGED	GFuLuGGGVG	GFsLsGGGVG	0	0	0	0
+8083	PF08251	Mastoparan_2		Mastoparan peptide	Rossi R	anon	Short protein clustering	Family	Mastoparan (MP) peptides I II and III are extracted from the venom  gland of the Neotropical social wasp Protopolybia exigua(Saussure) They are tetradecapeptides presenting from seven to ten  hydrophobic amino acid residues and from two to four lysine  residues in their primary sequences. These peptide cause the degranulation of mast cells. Protopolybia-MP-I also act causing hemolysis in erythrocytes.	25.00	25.00	26.10	26.10	16.50	15.00	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.18	0.75	-6.33	0.75	-3.35	2	5	2009-01-15 18:05:59	2005-05-04 09:49:55	6	1	3	0	0	5	0	14.00	76	100.00	CHANGED	INWLKLGKtV.shL	INWLKLGKtVIDAL	0	0	0	0
+8084	PF08252	Leader_CPA1		arg-2/CPA1 leader peptide 	Rossi R	anon	Short protein clustering	Family	In this family there are Leaders Peptides involved in the regulation the glutaminase subunit (small subunit) of arginine-specific carbamoyl phosphate synthetase.  In Neurospora crassa it is a small upstream ORF of 24 codon above the arg-2 locus [1]. In yeast it is the leader peptide of the CPA1 gene. The 5' region of CPA1 mRNA contains a 25 codon upstream open reading frame. The leader peptide, the product of the upstream open reading frame, plays an essential, negative role in the specific repression of CPA1 by arginine [2].	18.50	18.50	19.20	22.90	18.20	17.10	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.86	0.72	-6.75	0.72	-4.63	3	17	2009-09-10 15:06:03	2005-05-04 09:54:31	6	2	17	1	9	13	0	23.50	64	40.24	CHANGED	hstSsSQYTCQDYISDHIWKApSH	....FphS.SpYTCQDYISDHIWKoSS...	0	3	7	9
+8085	PF08253	Leader_Erm		Erm Leader peptide 	Rossi R	anon	Short protein clustering	Family	These short proteins are Leader peptides (15-19 amino acids) of  erm genes that code for resistance determinants in Staphylococcus  aureus [1].	21.00	21.00	24.90	24.40	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.28	0.72	-6.18	0.72	-4.47	5	32	2009-01-15 18:05:59	2005-05-04 11:41:20	6	1	23	0	1	13	0	18.80	80	82.42	CHANGED	MGhFSIFVIsTVHYQPNcK	MGhFSIFVINTVHYQPNcK.	0	0	0	1
+8086	PF08254	Leader_Thr		Threonine leader peptide	Rossi R	anon	Short protein clustering	Family	Threonine leader peptide of the Threonine operon thrA1A2BC.  It as been sequenced in different bacteria: E. coli, Serratia marcescens, Salmonella typhi [1,2].	25.00	25.00	25.40	26.20	18.50	16.70	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.04	0.73	-7.30	0.73	-4.09	2	68	2009-01-15 18:05:59	2005-05-04 11:43:54	6	1	68	0	8	11	0	21.20	87	98.63	CHANGED	M+hIS..TTIhTThp.TTG.GAG	MKRIS..TTIhTTITITTGNGAG	0	1	2	5
+8087	PF08255	Leader_Trp		Trp-operon Leader Peptide	Rossi R	anon	Short protein clustering	Family	The tryptophan operon regulatory region of C. freundii's (leader transcript) encodes a 14-residue peptide containing characteristic tandem tryptophan residues. It is about 10 nucleotides shorter than those of E. coli and S. typhimurium [1].	25.00	25.00	26.70	28.10	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.06	0.74	-6.50	0.74	-3.84	4	51	2009-01-15 18:05:59	2005-05-04 11:48:22	6	1	51	0	5	7	0	14.00	71	91.30	CHANGED	MsuhhuL+GWWRTS	MKAIFVLKGWWRTS	0	1	2	4
+8088	PF08256	Antimicrobial20		Aurein-like antibiotic peptide	Rossi R	anon	Short protein clustering	Family	This family of antibacterial peptides are secreted from the granular dorsal glands of the Green and Golden Bell Frog Litoria aurea, Southern Bell Frog L. raniformis, Blue Mountains tree-frog Litoria citropa (genus Litoria) and frogs from genus Uperoleia. They are a part of the FSAP peptide family.  Amongst the more active of these are aurein 1.2, aurein 2.2 and aurein 3.1; caerin 1.1, maculatin 1.1, uperin 3.6 [1]; citropin 1.1, citropin 1.2, citropin 1.3 and a minor peptide are wide-spectrum antibacterial peptides [2].	20.60	20.60	20.90	20.60	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.89	0.75	-5.92	0.75	-3.03	14	32	2009-01-15 18:05:59	2005-05-04 11:52:33	6	2	7	0	0	29	0	13.00	62	70.70	CHANGED	GlhDlsKKVsGtl	GLFDIlKKVsGsI..	0	0	0	0
+8089	PF08257	Sulfakinin		Sulfakinin family	Rossi R	anon	Short protein clustering	Family	The sulfakinin (SK) family of neuropeptides have only been identified in crustaceans and insects.  For most species there is the potential for producing two sulfakinin peptides one have a short sulfakinin sequence The function of the sulfakinins is difficult to assess.  For the American cockroach, various forms of the endogenous sulfakinins have been shown to be active on the hindgut, and also on the heart.  In C. vomitoria the peptides act as neurotransmitters or neuromodulators, linking the brain with all thoracic and abdominal ganglia.  In adults of P. monodon they appear to be restricted to a few neurones in the brain with a neural pathway extending along to the ventral thoracic and abdominal ganglia [1].	21.20	21.20	21.50	21.50	18.50	20.80	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.41	0.76	-5.79	0.76	-3.28	2	53	2009-01-15 18:05:59	2005-05-04 11:55:08	6	1	50	0	0	7	0	9.00	92	82.10	CHANGED	.-DYGHMRF	F-DYGHMRF	0	0	0	0
+8090	PF08258	WWamide		WWamide peptide	Rossi R	anon	Short protein clustering	Family	This family contain neuropeptides, isolated from ganglia of the African giant snail, Achatina fulica.  Each peptide has a Trp residue at both the N- and C-termini.  Purified WWamide-1, -2 and -3 showed an inhibitory effect on the phasic contractions of the anterior byssus retractor muscle (ABRM) [1].	19.40	2.80	19.40	2.80	11.30	-4.50	hmmbuild  -o /dev/null HMM SEED	7	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.27	0.77	-5.57	0.77	-2.79	2	19	2009-01-15 18:05:59	2005-05-04 13:22:39	6	2	2	0	0	18	0	7.00	83	27.71	CHANGED	W+pMSVW	WKQMSVW	0	0	0	0
+8091	PF08259	Periviscerokin		Periviscerokinin family	Rossi R	anon	Short protein clustering	Family	Abdominal Perisympathetic organs of insects contain  Periviscerokinins neuropeptides of about 11 amino acids. 	19.50	19.50	19.50	19.50	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.64	0.75	-5.78	0.75	-3.14	3	195	2009-01-15 18:05:59	2005-05-04 13:39:12	6	1	82	0	0	34	0	10.90	75	99.16	CHANGED	GSSGLIPFPRV	..GSSGLIshPRV.	0	0	0	0
+8092	PF08260	Kinin		Insect kinin peptide	Rossi R	anon	Short protein clustering	Family	These neuropeptides are the first members of the insect kinin-family isolated from the American cockroach. Their occurrence in the retrocerebral complex suggests a physiological role as a neurohormone. The C-terminal sequence Phe-X-Ser-Trp-Gly-NH2 characterised the peptides as members of the insect kinin family.  Data suggest a possible involvement of insect kinins in water-balance by regulating the osmoregulation. These peptides have length from 6 to 14 amino acids [1].	19.70	19.70	21.90	21.90	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.55	0.76	-5.53	0.76	-2.79	3	5	2009-01-15 18:05:59	2005-05-04 13:46:48	6	1	2	0	0	5	0	8.00	79	100.00	CHANGED	cPAFNSWG	DPAFNSWG	0	0	0	0
+8093	PF08261	Carcinustatin		Carcinustatin peptide	Rossi R	anon	Short protein clustering	Family	A total of 20 peptides of the superfamily allostatin were isolated from the shore crab Carcinus maenas. They are named carcinustatin 1 to 20 and their length ranges from 5 to 27 amino acids. This family includes carcinustatin 8,9,15 and 16.	20.70	0.50	20.70	0.90	20.20	0.40	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.30	0.77	-5.42	0.77	-2.46	2	2	2012-10-01 21:03:17	2005-05-04 14:12:48	7	2	2	0	0	66	0	8.00	88	2.84	CHANGED	uGPYuaGL	..AGPYuFGL	0	0	0	0
+8094	PF08262	Lem_TRP		Leucophaea maderae tachykinin-related peptide 	Rossi R	anon	Short protein clustering	Family	These peptides are designated Leucophaea maderae tachykinin-related peptides (Lem TRPs). Some were isolated from the midgut of L. maderae, whereas others appear to be brain specific.  The Lem TRPs of the brain are myotropic and induce increases in the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle in L. maderae [1].  They were also isolated from brain-corpora, cardiaca-corpora, allata-suboesophageal ganglion extracts of the Locusta migratoria.  They stimulate visceral muscle contractions of the oviduct and the foregut of Locusta migratoria [2].	25.00	25.00	26.90	26.90	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.20	0.74	-5.42	0.74	-3.63	4	4	2009-01-15 18:05:59	2005-05-04 15:39:16	6	1	2	0	0	4	0	10.00	72	100.00	CHANGED	APSMGFpGhR	APSMGFpGhR	0	0	0	0
+8095	PF08263	LRRNT_2		Leucine rich repeat N-terminal domain	Bateman A	anon	Pfam-B_35 (release 17.0)	Family	Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.	20.70	3.10	20.70	5.20	20.60	-999999.99	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.56	0.72	-3.99	101	5573	2009-09-16 14:48:15	2005-05-06 17:06:28	7	2088	260	5	3276	5555	7	41.00	31	5.53	CHANGED	hss-tpuLLshKsulst.......ss....shLsuWsss........sssCs...WpGVsCs	........................p-tpALLphKp.u.ls....................ss.........shL..s..o...Wsss................sssCs.........Wp.GVsCs..............	0	335	1979	2672
+8096	PF08264	Anticodon_1		Anticodon-binding domain of tRNA	Bateman A	anon	Pfam-B_23 (Release 17.0)	Domain	This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.94	0.71	-4.46	171	17806	2009-12-15 13:50:21	2005-05-07 14:43:35	8	114	4976	36	4987	14537	7549	145.80	20	16.55	CHANGED	D+alLsclpphlpplspsh-.p.apaspshptlhpa...hhsphsshYlchs+sph.t.....................tslhpslcthlplLsPhhPaloEEla.......................t..........t.l..hh.....tt.a..P..p..........ptph............................................hphh.tl....lphhcp....hR...........sphpls.tstp......hphhl	..........................................................pphhhpphppslp.p.l.s.c.s.h..-.......p..acFspAhp.tlhp.F..........hhsc.hsshY.l..-..hs.K..s.h.h...htttt.t......................s...................ssl...h...p...s...l...c...s...l...l...+...llsPhhPalsE...E..lW...........................................................................ttt........pol....hh.......ss...a...Pp..s.t.h.........p.th.............................................................................tt.thp.h.h..t.l.........lp.s.htp.........hR...............sc.h.pls..sh........h...........................................................................................................	0	1700	3159	4209
+8097	PF08265	YL1_C		YL1 nuclear protein C-terminal domain	Bateman A	anon	Pfam-B_3088 (release 8.0)	Domain	This domain is found in proteins of the YL1 family [1]. These proteins have been shown to be DNA-binding and may be a transcription factor [1]. This domain is found in proteins that are not YL1 proteins.	20.60	20.60	21.30	21.00	19.70	18.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.05	0.72	-4.38	51	540	2009-01-15 18:05:59	2005-05-07 14:55:52	6	11	291	0	386	523	1	29.80	42	8.37	CHANGED	chCsITGh.ApYhDPpT.pl.Ytss-saphl	.....hCsITGLsApYpDPpT.pL.Ysss-sFphI......	0	114	198	309
+8098	PF08266	Cadherin_2		Cadherin-like	Finn RD	anon	Pfam-B_179 (release 17.0)	Domain	This cadherin domain is usually the most N-terminal copy of the domain.   	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.54	0.72	-4.41	77	2331	2012-10-03 16:25:20	2005-05-09 16:18:59	7	43	53	2	1054	2531	1	83.80	38	9.36	CHANGED	spl+YSVsEEscpGohVGNlAKDLGLslp-LusRshRllSpspcpahplshcoGsLllsE+lDREcLCupstsClLphplllEs	...........................................pl+YSlsEEhcpGohVGN.l.A.....c..D...L.....G....L....p.l.....t............c.....L......s...s....R.....p.....hR.ls..o..p..s......p......p.............phl.plshpsGt.L.h.l.s.c.+.IDR.E..pL..C...u........p....s.....s...t...Chlph-lll-.........................	0	88	224	576
+8099	PF08267	Meth_synt_1		Cobalamin-independent synthase, N-terminal domain	Finn RD	anon	Pfam-B_553 (release 17.0)	Domain	The N-terminal domain and C-terminal domains of cobalamin-independent synthases together define a catalytic cleft in the enzyme.  The N-terminal domain is thought to bind the substrate, in particular, the negatively charged polyglutamate chain.  The N-terminal domain is also thought to stabilise a loop from the C-terminal domain [1].	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.71	0.70	-5.16	56	2913	2012-10-01 21:20:02	2005-05-09 16:57:19	7	5	2719	25	628	4722	465	302.40	41	42.29	CHANGED	tspsLG.aPRIGtpRELK+AlEsYWpGchs...pp-LhpsucpLRtppWptQpssGlDh....lPsuDFoaYDaVLDtshhhGslPpRat.......t....sLDpYFshARGs....tsh...sAhEMTKWFsTNYHYlVPEhspsppFpls.ssphlp-hpEA.ptlG.h.....csKPVllGPlTaLhLuK....ststs....shhs.................LLppLlslYpclLpcLsstGsc.aVQlDEPsLshDl..spphhpshcpsYppL.........ttssscllLsTYFss.hscphshl..hpLPVs.GltlDlVc.uscpLssltp.ths..scKhLuAGll-GRNIW+sDLppsLphLppltpths	........................................................................................................h.sphLG.FPRlG.....p..RELKhAhEsYWt.....sc..ho.........c-...-Lhtsu+......-LRtcpWphQpp...s.G.l...Dh....lPs..sDFuaYD.pVLDsuhhh...GslPtRap............t..st..........ss....lDphFthuRGp...........................tsssAhEMTKWFsTNYHYlVPEas.p.s.........p..........pF.c......L.......s......h..s.......pll-EhpE.....A.....ps.L...G..h.............ps+PVLlGPl.....T...a...L..h...LuK...spsts........sths.............................................lLsc.LL.P.lYpplLscL.sc.t...........Gsc...WlQlDEP...s......L...V......h............DL........spp....h.......h......s....t....a....c......p.......s..Y.stL...................tpstsKlLLp..T..Y............F..ss..........l......t....c...........s..........h..stl....ss..L.P.Vs.GltlDhV.....c.....utcs.....L...s....tl...p.p......t.hs.................scphLsAGl....lsGRNlWRsDlppphshlcplht..t.......................................................................................................................	0	176	381	529
+8100	PF08268	FBA_3		F-box associated domain	Finn RD	anon	Pfam-B_322 (release 17.0)	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.94	0.71	-4.41	51	607	2012-10-01 23:07:08	2005-05-09 18:41:09	7	19	34	0	459	913	0	116.00	20	32.80	CHANGED	GlCING.VlYYhAhh..................sp.....phhlhsFDVRSEcF.shIph..................h..hthsLlsYcGKLuh..h..s..t........lclWVLE.DscK.pcWS.+pha...hhs.s..th.....hphplsGsTps.GE..llhh.........sphhppsFal	.......................................................................hsG.hlYah.s.......................t.......p.hlhsFDlp.sE.pF..p.hlph............................................t.t.hpL..l..ph....p..G....+.Luh.....ht.hpp.t............................hcl.Wl......Lc.....D...h..c..c..p.p.Wo.+h.hh......h.......................................................................................................................	0	120	175	213
+8101	PF08269	Cache_2		Cache domain	Finn RD	anon	Pfam-B_865 (release 17.0)	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.12	0.72	-4.01	34	2356	2012-10-01 23:40:40	2005-05-10 17:25:59	6	99	833	2	845	2155	121	91.30	24	17.47	CHANGED	+sshhpp+cppLpshlptAhshlphhtp.sptsphsc-pApppupphl..............pslRa.ssssYFalhDppsthlhHPhpPcL.Gpshts.hpDspGstlhp	................................................................thhpt+ctplpphl.p.hAhshlp.....hhpts..t......t..sth.s....cp.pA..p....p.p..u...hphl..................................psh..+...a....s...s....s......s.Y.h.a.l..h........D.....t....p.....s...s....h...lh.HP.h.ps..c.h...G.p.....s.hh.s..hpDsp.Gphlh..................	0	253	511	690
+8102	PF08270	PRD_Mga		M protein trans-acting positive regulator (MGA) PRD domain	Moxon SJ, Bateman A	anon	Pfam-B_5126 (release 7.7)	Family	Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1]. This corresponds to the PRD like region.	21.00	21.00	22.50	22.50	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.10	0.70	-5.07	13	638	2012-10-02 16:05:11	2005-05-11 14:46:11	6	4	320	0	27	325	1	210.10	29	43.86	CHANGED	spphlcchl...shplppo.hshh.shFpaaclLlulsaKR..+ta.lslPpstlh......cplpplhhhsplhpsspphlt.caslshspsslsYlFLsYloss.shu.sthhsppctcphhphhpchssaptLLc.lpctLshphss+pclhptL...saFp+p.lhshphLI.-hpthshptaptph.pLYptlcshlpcahpphst..ptplpppchahhshalEpl	...............s.p-.lsphl...shhhKposhshshspaphh+lLlshshhR..hsa.h-lspsph.......cphhshh.h.s...hh...ctstp.h-scaslshsp-sls.lFlsYhpsth.ls.p.hhpshccsphsc..hshp......hhs..pll-plptphtlphpN+spllhtL..........sahhRppLFs.phllh-p+t..slcpaps.a.phhss.lKp.lpcahpshph.....pshhspHhhYhhhh+hcpL........	0	5	10	19
+8103	PF08271	TF_Zn_Ribbon	TFIIB_Zn_Ribbon;	TFIIB zinc-binding	Finn RD	anon	Pfam-B_1298 (release 17.0)	Domain	The transcription factor TFIIB contains a zinc-binding motif near the N-terminus.  This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site.  The domain adopts a zinc ribbon like structure [1].	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.38	0.72	-4.64	71	1235	2012-10-03 10:42:43	2005-05-11 16:17:32	7	14	529	7	745	1178	225	42.80	34	11.75	CHANGED	htCPpCsu.sp.l.....lhD...ppG-h.lCssC.GhVl--phl-pssEacsh	............h.hCPp..Css..s...l...........lhD.....p..pG-h.lCs.....pC.GhVl...p..-phlDttsEWRs................	0	230	423	611
+8104	PF08272	Topo_Zn_Ribbon		Topoisomerase I zinc-ribbon-like 	Finn RD	anon	Pfam-B_5615 (release 17.0)	Domain	Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to Pfam:PF01396. However, this domain no longer bind zinc.  Indeed, only one of the four cysteine residues remains [1].	25.00	25.00	28.90	28.90	19.10	16.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.72	0.72	-4.60	19	1903	2012-10-03 10:42:43	2005-05-11 16:18:39	6	10	949	2	262	1090	300	41.40	39	9.71	CHANGED	u.ssllpas++scppYlpoct.sGKhouWpsaapstcWpssph	.....t.splsp.p+pst..hlps.ts...sGh..hhuhssF.pstchpsshh.......	0	40	98	188
+8105	PF08273	Prim_Zn_Ribbon		Zinc-binding domain of primase-helicase	Finn RD	anon	Pfam-B_18441 (release 17.0)	Domain	\N	21.80	21.80	21.80	21.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.35	0.72	-3.88	18	651	2012-10-03 10:42:43	2005-05-11 16:18:46	7	22	488	2	103	533	210	37.60	54	6.24	CHANGED	t+HsPCPsCGupDta+.asDt.st.........GshaC.sC...u......sGDGh	......+HsPCPs.C...G.G....c..DRFR.FD.Dp...cGp...........GoWhC.N..pC......G......uGDGh............	0	21	44	78
+8106	PF08274	PhnA_Zn_Ribbon		PhnA Zinc-Ribbon 	Finn RD	anon	Manual	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.62	0.72	-4.16	34	2095	2012-10-03 10:42:43	2005-05-11 16:19:05	7	3	2023	1	331	1007	47	31.30	58	26.06	CHANGED	sL.....P...pCPpCsSEaoY............pDsslhlCP-CuaEWs	...........LP...sCPcCsSEYTY............EDsuhhlCPECAaEWs...	0	97	190	266
+8107	PF08275	Toprim_N		DNA primase catalytic core, N-terminal domain	Finn RD	anon	Pfam-B_313 (release 17.0)	Domain	\N	21.40	21.40	21.50	21.50	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.86	0.71	-4.19	93	4712	2009-01-15 18:05:59	2005-05-11 16:22:45	6	53	4423	10	1053	3634	2781	126.40	37	20.82	CHANGED	aapppLpssps.....AhsYLp.pRG.lstchlccFplGaAP...ps.........hptLh..phltp.cshs...p.lhpsGLltpppt..stha..Dp......F+sRlhFPIpctpG.cl.luFGGRsl..............sspp..s.KYl...NSPET.lFcKuchLY.uhtpA+	.......................................................................................................aapp.t.L.p.sstu...t....AhpYLp..pRG..lo..s.....-hl.pcF...tlGaAP....ss.............................hs.slh...chh......tp...pshsp....ptLh.cuGL.lhps-p..........sphY...DR..................F..R.s.R.lMFP...Ics...t..p.G....+V.lGFG..GRsL...................sssp...s.KYL...NSP...E.Ts.lFcKuc.LYultpA..........................................................	0	367	705	894
+8108	PF08276	PAN_2		PAN-like domain	Finn RD, Mistry J	anon	Pfam-B_291 (release 17.0)	Family	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.89	0.72	-4.13	106	1792	2012-10-02 11:41:37	2005-05-11 16:56:24	6	91	83	0	773	1862	3	65.90	34	10.50	CHANGED	C..........tssDtFhplp.shKL..PDs.sth.hp.ps.hshc-CcppCLpsCSCTA..YAh..ssh......su......sGCllWp...u-LhDh	...........................................C.....psD.sFhp.hp..shK.L....P-.sp.t..s.h...hs......ps..hshc-Ccp.pCLp.sC.s.CoA..aA...sshp.....su..........sGC....llWh...s-.LhDh................	0	36	432	619
+8109	PF08277	PAN_3		PAN-like domain	Finn RD	anon	Pfam-B_1455 (release 17.0)	Domain	\N	21.10	21.10	21.10	21.80	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.68	0.72	-4.36	43	345	2012-10-02 11:41:37	2005-05-11 16:56:38	7	19	14	0	344	322	1	69.90	22	24.54	CHANGED	MlllaGpPssh....ss.phpshsacsClstChpsssCllsats...ss..sCthaph...ss.lsslpp...hpssssphl.AhKh	..............................MlhhaGpstsh........ss.tttshsappClppCapss.s...Cllsahs....ss........pChhaph.......ss...l....p...lpp.....hp...pss..t..t..hl.AhKh.....................	1	74	107	344
+8110	PF08278	DnaG_DnaB_bind		DNA primase DnaG DnaB-binding 	Finn RD	anon	Pfam-B_3213 (release 17.0)	Domain	Eubacterial DnaG primases interact with several factors to from the replisome.  One of these factors in DnaB, a helicase.  This domain has been demonstrated to be responsible for the interaction between DnaG and DnaB[1].	26.80	26.80	26.90	26.90	26.40	26.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.56	0.71	-3.92	90	1338	2009-09-10 21:47:29	2005-05-12 11:10:45	6	11	1330	3	256	893	235	126.70	34	21.41	CHANGED	s.hRtsluLLlQpPpLAttls..shtslpphp.s..uhslLhpLlphspp.psshsou.p.....LLEpaR...sssttphLppLAs...hp.phl..s--shpppFt-slspLhpp.h....lcpclppL..huKspt.ts..LospE..+pcLtpLl	.....shRhlIuLLlQNPpLAshVs......shtslcp.p..hP.......GlsLhp-.Llpssh...u..pPu.l.oTG.Q.........LLEpaR.....so.spsssLcpLut.................W-clh..-cs...h....hEppFsDoLs+lhcp.h.....lcp.chEpLhA+pRs...pG...LosEE..+h.ELhsL........................	0	50	142	210
+8111	PF08279	HTH_11		HTH domain	Bateman A	anon	Pfam-B_125 (Release 17.0)	Domain	This family includes helix-turn-helix domains in a wide variety of proteins.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.58	0.72	-4.32	103	12449	2012-10-04 14:01:12	2005-05-13 11:46:06	7	125	3577	14	2246	23862	1739	54.70	24	15.12	CHANGED	Rttpllph..Lhpscp..louppLAccLsV.Scpolh+DIptL.pttG.....h.Ituptsh..GYt	...............................pllph....L...p..s..p...p......l.......o.u.p.p......L.....Ac..p..l.....s.....V...Sc.....pTl....h+-l....p.t....L...pphs................h...l...u....t..th.....GY.........................................	1	790	1488	1900
+8112	PF08280	HTH_Mga		M protein trans-acting positive regulator (MGA) HTH domain	Moxon SJ, Bateman A	anon	Pfam-B_5126 (release 7.7)	Domain	Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.56	0.72	-4.21	16	958	2012-10-04 14:01:12	2005-05-13 11:47:10	6	23	527	3	56	1743	53	58.10	27	12.18	CHANGED	EccItcclcLlslLhc.ppphshs..-lscpLshothplpphlppLpth.Fscplthphpcst	................pKc.pRplp...LlchLhc..pphh.p....lp..ELuchLssoc+slps-Lsclppt..Fsp..h.hhp.pps.h...............	1	15	32	46
+8113	PF08281	Sigma70_r4_2		Sigma-70, region 4	Bateman A	anon	Pfam-B_125 (Release 17.0)	Domain	Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.16	0.72	-4.50	141	24630	2012-10-04 14:01:12	2005-05-13 11:47:27	7	126	3614	8	7611	38704	4348	53.10	25	25.60	CHANGED	tttltphlppLstpp+plhhLpthpshshpEIAphl.....sls.ssVcpplpRApppl	......................h...l.pslppL...s....t.c...p...R...p...s...l...h.L....p....h......h......p....u.......h.......o....h.....p.......EIAphl........s.l.s.h.uoV+splpRAppph...........................	0	3028	5560	6758
+8114	PF08282	Hydrolase_3		haloacid dehalogenase-like hydrolase	Bateman A	anon	Pfam-B_66 (Release 17.0)	Domain	This family contains haloacid dehalogenase-like hydrolase enzymes.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.36	0.70	-4.81	69	20961	2012-10-03 04:19:28	2005-05-13 16:17:25	7	63	4356	221	3153	23365	3191	223.30	21	85.03	CHANGED	lshDlDGTL.Ls..............pspp.ls.ppstpslpchpp........pGhhlslATGR..shhshhphhp.pLs..lp...hhhls...hNGuhl.....tpsphl.hpphls...pctlppllchhpphp.......hphhhhs...scshah.pt..........................thhhhtpthtthhhthtp.t.htspshhKlh.....hhtstpphpph..tpplppph.............shhpottthl-..lhspsssKupulptls..pthslshpcshAFGDutNDlpMlphu....GhulAMuNAspplKphAch..lsssssc.sGluchl	.........................................................................................................................................................................................................................lshDhDGT.L..Ls.........................................................s.p..p....p....l...s.........p.shps.l.p.p.h.p.p.........p.Gh...h.slso...GR...........h....h....t....h.....h..........h...h....p...p....lt....hp...........................hls..........N.Gu.hl................t.pt....p......h...l....hp...p......ls...................p...h.....p.lh..p..hhpp.t.............h.h.h.h..hs.........tp...th.hh.pt...........................................................................................................h...........h.................................t......................t....t....t....h.hchh..................h...p......t...t...h..t.th..........t..t...l...t...t....h.....................................phh..h...s...t...........h..l..-......l..h....t..s....s.....s...Ku....pu.......l....p......p.lh...........cp..h.............s.............l.......s.................p.....p.......s...h..A...h..G....D......sh....NDlpMl....p..h.s........G.h.u.l..A.M...s...N...A...t...s...p...l...K.t....h...A..s..h.....l..s..t..sspp..pGlhthl................................................................................................................................................	0	948	1870	2569
+8115	PF08283	Gemini_AL1_M		Geminivirus rep protein central domain	Bateman A	anon	Pfam-B_286 (release 2.1)	Domain	This is the cetral domain of the geminivirus rep proteins [1].	20.80	20.80	21.10	21.30	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.55	0.72	-4.21	13	2813	2009-01-15 18:05:59	2005-05-13 16:58:13	6	5	1027	0	3	2628	1	102.40	48	32.13	CHANGED	uQpsusDsht+Al..NusS+EEALsll+-chPc-aslphHNlpsNssRlF.csPEsassPFP.SS.FsplPEplp-WssspltpsSAt.hshR..SlllEG-SRoGKThW	..............................tpQoANDA.YAcAl..NuGSKpEALpll+EchPK...Dall.QaHNLsuNL-R.IFstPs.p.s..YlsPFs.SS.FspVP-Elp-Wss.-Nlh.....s.....u.....A....A..........R....P..........hRPhSIllEGD..SRTGKThW...................	0	2	3	3
+8116	PF08284	RVP_2		Retroviral aspartyl protease	Bateman A	anon	Pfam-B_	Domain	Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.57	0.71	-4.23	7	1125	2012-10-02 15:32:34	2005-05-13 17:10:21	6	93	68	0	570	1652	9	115.90	36	9.78	CHANGED	shspuRVNHlsAEpsQsuP-VlhGTF.VNSlPAoVLFDSGAoHSFIStsFVttHulth.pL+pPhhVpoPGsshpusphsPuVslcIpGlsF.us.IlLcSpsLDVILGMDWLspacGVIDCApRolsLTsspGc	........................................t............t.p.....t.t....t...l...lh..s..hh.......lps...hsshl..LhDSGAo.....HSFlSht.F.s.tp..p.t......h...t.h.p....p..L....p..p.....P..h.h.l....p.....o.....P.u...s...p...h.....p...s.....t..t...h..s...s...s...l..........s..l...c..I..p...s....h..s...F......u..s.L.I....l......L.-..s...c.......s.l...D...V..ILGMsWLspa.p.u.l.I.DC..s..p+plsl.t................................	0	109	151	165
+8117	PF08285	DPM3		Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)	Mistry J, Wood V	anon	manual	Family	This family corresponds to subunit 3 of dolichol-phosphate mannosyltransferase, an enzyme which generates mannosyl donors for glycosylphosphatidylinositols, N-glycan and protein O- and C-mannosylation.  DPM3 is an integral membrane protein and plays a role in stabilising the dolichol-phosphate mannosyl transferase complex [1].	23.80	23.80	25.30	24.90	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.00	0.72	-4.14	23	232	2009-01-15 18:05:59	2005-05-17 13:34:31	6	3	205	0	169	218	0	88.40	35	92.74	CHANGED	Mo+hpchlhhhshlsulahulhhshls....sp..hppll.hLPhahLVsFGsYuLsslGaslhTFsDs.-stcELhppIcEAKc.L+pKGlcl	..............................................MT+htphl.hhhllsu.......lahu..Lhhshls...................ls.....ppll..hLP..h.ahLVshGsYuLhplGatlhTFsD...ss-AtpELppcIpEA+t-Lpp+Glc..........	0	45	83	133
+8118	PF08286	Spc24		Spc24 subunit of Ndc80	Mistry J, Wood V	anon	manual	Family	Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation [1]	22.60	22.60	22.70	23.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.56	0.71	-4.40	24	178	2009-01-15 18:05:59	2005-05-17 14:02:25	6	1	166	4	123	167	0	116.60	28	57.89	CHANGED	lhcL-spphcluKphscLEsplppLpsplpcLppphp-lpppt.p................sscttt.......ss.cuslL+L+LYRsLG.lpl-t...t..........................-tspsl.I+spcpss.....lpslsl-s.phScaFhosYlWspL	................................................................pL-spphcluKphscLE...tp......hpp...Lps-LpcLcppht-L-ppth-...........................sppps.................stsuslL+L+lYRuLG.Icl-h..............................phspsl..I+sp...ccGs..............lpslslDs..phScaFhusYhWpth.........	1	32	62	95
+8119	PF08287	DASH_Spc19	Spc19; 	Spc19	Mistry J, Wood V	anon	manual	Family	Spc19 is a component of the DASH complex.\	     The DASH complex associates with the spindle pole body and is important for spindle and kinetochore integrity during cell division [1][2].	25.00	25.00	27.90	27.10	24.70	24.00	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.66	0.71	-4.60	20	131	2009-01-15 18:05:59	2005-05-17 16:15:36	6	2	128	0	99	123	0	146.60	35	82.74	CHANGED	oLsssVsSLpuSlplLcsS...lstLcsuspDhPRLs.pVLpTsRhFELlPEs-LppAppslh-EIpPplppLls+l-cplp+LpR+cpsLpsKhELppsRLpsspspssssptt......................s...h.sssspcltcL+tLppKKERLpYslpRL	.........LpssVsSLcuSlplLcsS...lphL-suspDhPRLs.plLpTsRaFELlPEsslppAptuLh-EIsPtls..pLls+scpplp+hpR+.psLpu+sE.LppuRLppspstssssstt.....................................tpt.shht.shsspc.htcL+tLppKK-pLpYsl-RL..........................................	0	24	52	83
+8120	PF08288	PIGA		PIGA (GPI anchor biosynthesis)	Mistry J, Wood V	anon	Pfam-B_6971 (release 17.0)	Family	This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria [1].	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.93	0.72	-3.62	23	340	2012-10-03 16:42:30	2005-05-17 16:20:46	7	6	290	0	246	348	6	87.90	55	19.14	CHANGED	HuYs.sRpGVRYLTNGLKVYYlPahVhYcpsohPThFusFPlhRsIllREpI-IVHGHuuhSoLuHEuILHA+TMGl+TVFTDHSLFGFAD	.................................HAYs.sRpG.VRYLTNGLKVYYlPhhVh...a...p...psThPTlFs.shPllRs.........Ihl..REpIp....IVHGHu.ohS.shsHE....Alh..H..A+TM..G..L+TVFTDHSL.FGFAD...................	0	86	132	206
+8121	PF08289	Flu_M1_C		Influenza Matrix protein (M1) C-terminal domain	Bateman A	anon	Pfam-B_30 (Release 17.0)	Domain	This region is thought to be a second domain of the M1 matrix protein.	20.80	20.80	20.80	23.80	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.21	0.72	-3.96	2	22741	2009-01-15 18:05:59	2005-05-18 12:08:22	6	2	22466	0	0	3048	0	94.30	91	38.38	CHANGED	pHRuHpphspoosPhlR+E.pMV.A.sTAKsMptMu....put-s.clApphpp.ltshRslGsp.psutGltpDlhEsLp..QppMG..s.hp+ah	......QHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMG..VQMQRFK.	2	0	0	0
+8122	PF08290	Hep_core_N		Hepatitis core protein, putative zinc finger	Bateman A	anon	Bateman A	Domain	This short region is found at the N-terminus of some hepatitis core proteins.\	 Its conservation of four cys and his suggests a zinc binding domain.	25.00	25.00	26.10	27.40	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.29	0.72	-4.51	2	5101	2009-09-11 06:29:00	2005-05-18 14:57:32	6	7	66	0	0	2681	0	26.90	96	24.69	CHANGED	hphFpLCLIISCoCPThQASKLCLGWL	....MQLF.HLCLI.ISC.S.CPTVQASKLCLGWL.....	0	0	0	0
+8123	PF08291	Peptidase_M15_3		Peptidase M15 	Finn RD	anon	Manual	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.40	0.72	-4.25	19	623	2012-10-02 01:02:30	2005-05-19 09:30:08	6	14	470	1	168	1206	1181	110.70	24	47.23	CHANGED	taFphpEhspsssssppslD...............plhshLpslRcpaGp..........PIhloSGaRssthNppVGGApsStHhpG.....pAADlpshst.sspcltphhc...sphstch....Ghttts....salHls	..........................................................h.....tt...............t.h.............................thhphL...ctl.Rp.t..h.st..........Pl.h..l.o..........SG.......YR........s...phN.......c........p.....l........G....G......u.....s.....s.....S.pHh..hG.........pAuDltls..........sh.....s.......p.l..t....p.hht......ph.h.....t...........hh...t..........talHls.............................................................	3	78	128	153
+8124	PF08292	RNA_pol_Rbc25		RNA polymerase III subunit Rpc25	Mistry J, Wood V	anon	Pfam-B_9841 (release 17.0)	Domain	Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III [1].	24.20	24.20	24.40	24.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.37	0.71	-3.92	33	328	2012-10-03 20:18:03	2005-05-19 09:32:39	7	9	290	3	240	371	3	116.40	35	51.74	CHANGED	PFhGEllpG.pIpssopcGI+Vol.uFF-D.........IalPhs.L......-sspa..cpp-psWlWpht................-ppchahDhsEplRFRVppphF..-.pPhs.t..........................ttttpttppphssatll.GShppsGLGhloWW	..............PFhuEllhG.+Ipsso.t.cGl+lol.sFF-D.........IhIPsphL....................psu...p....F............-ps..-..p...s...WlWcht.........................pspcLahDh.sEplRFRVppE.a.hD.pPtssp...............................................ttt....tttpp.sPYplh.GShppsGLGhluWW..........................................	0	82	132	196
+8125	PF08293	MRP-S33	Mit_rib_S27; 	Mitochondrial ribosomal subunit S27	Mistry J, Wood V	anon	Pfam-B_31036 (release 17.0)	Family	This family of proteins corresponds to mitochondrial ribosomal subunit S27 in prokaryotes [1] and to subunit S33 in humans [2]. It is a small 106 residue protein.The evolutionary history of the mitoribosomal proteome that is encoded by a diverse subset of eukaryotic genomes, reveals an ancestral ribosome of alpha-proteobacterial descent that more than doubled its protein content in most eukaryotic lineages. Several new MRPs have originated via duplication of existing MRPs as well as by recruitment from outside of the mitoribosomal proteome [3].	25.00	25.00	25.10	28.20	23.20	24.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.07	0.72	-4.01	30	282	2009-01-15 18:05:59	2005-05-19 09:52:05	6	4	245	0	194	253	2	88.60	34	73.37	CHANGED	shhhclscluu+IFupshNPsstRoGs..KlLppcL..+Gspls...sYY..Psth.papphcphhs..thhhhD.cEsh....Rhphlch.................+KtRGKGsP......KK	...............hhhchs+Lps+IFupshp..Ps.st+ohp...Klhppc....+sspls...saY....Ppchhhh.t.h.pphh...............hhhhhDEcpch....+.chhch.................+KhRGKGtP.....KK................................	0	58	99	154
+8126	PF08294	TIM21		TIM21	Mistry J, Wood V	anon	manual	Domain	TIM21 interacts with the outer mitochondrial TOM complex and promotes the insertion of proteins into the inner mitochondrial membrane [1].	20.40	20.40	20.90	21.10	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.70	0.71	-4.54	13	289	2012-10-01 19:51:31	2005-05-19 10:32:58	6	5	252	1	206	280	0	136.30	30	55.74	CHANGED	Kl+cssphoh.hhlVluGlGloGlllYlIhsELFSsSucspIFN+AlpplcsctcspslL........GcplKuaGEtsppsR..RsRshVSppch-+cGhcHhhM+FHVEG..s++pGhVplEhpcsstp..hp.-Fhaha..lDlssc++Ihlhcs+	...............+ltcssppss.hhlllhGlulo.uslhYhl...apELF.u.s.s.Sssplas+Alc+lcpcscl.hshl...............Gp..l+...uYG..E..t..op...s+.....R.hs.op.h.p.h..c..+..c.Gh.......cHhphpFalcG..stppGhVph-hhcs.tp......tpa.-apalh..l-s.......s....p..p.p..hhl.p.....................	0	62	107	166
+8127	PF08295	Sin3_corepress	HDAC_interact;	Sin3 family co-repressor	Mistry J, Wood V	anon	Pfam-B_2731 (release 17.0)	Domain	This domain is found on transcriptional regulators.  It forms interactions with histone deacetylases [1].	25.00	25.00	26.90	25.50	22.80	23.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.39	0.72	-4.26	26	505	2009-01-15 18:05:59	2005-05-19 10:38:32	7	10	275	0	333	477	4	97.90	45	7.99	CHANGED	sCcphGPS....YRhLPKs...s.CSGRschs...tpVLNDpWVShPohu.ED.tuFhshRK.NQYEEsLa+sEDERaEhDhllEuspsoIchLEplhpclpshspc-cts	.........................pC+phGsS....YRhLPK.s..htt...CSGRstLC..................ppVLNDpW.VSa.P.oWu..E....D.S.s.Flu.p........+.K..sQYEEpLaRsEDER..aEhDhllEsshs...TIphLEsltp+ls.pho.c-p..p...................................	1	122	194	269
+8129	PF08297	U3_snoRNA_assoc	U3_snoRNA; 	U3 snoRNA associated	Mistry J, Wood V	anon	manual	Family	This family of proteins is associated with U3 snoRNA [1]. U3 snoRNA is required for nucleolar processing of pre-18S ribosomal RNA.	25.00	25.00	27.30	27.30	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.80	0.72	-3.75	21	98	2009-09-11 16:06:36	2005-05-19 11:16:19	6	3	96	0	72	97	0	90.70	27	29.00	CHANGED	chLP--lLsshspssssss.tps....................h.tpphKtpKh+hLcphcK..psl+hGsVslpVLsspsst.....pLsPKucppshssK-pWLpRp	............thLP-ElLps.sppc...sss.tpp............................tpp...hcspKh....+hLcphcK.....csl+hGsssl+VLssssst.........pLsPKspppshpsK-pWLpR.....	0	10	33	61
+8130	PF08298	AAA_PrkA		PrkA AAA domain	Vella Briffa B, Bateman A	anon	Pfam-B_3917 (release 10.0)	Domain	This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.18	0.70	-5.76	7	1391	2012-10-05 12:31:09	2005-05-20 09:52:18	6	8	1305	0	343	3100	1561	347.80	58	55.27	CHANGED	hoht-YL-hs+ps.pshtsAtcRlhshIt-s....hlcsttp.+lt+latNcsI++YshFs.-FaGhE-sl-+IVs.YF+tAAptLEE+KQILYLlGPVGGGKSSLsEpLKplhEhh......PlYsL.....ctsPhaEpPLpLh.PpchtphhEccaGI...clpG.hSPhsshRL.cEFGG-IpcFpVsKlh.ShhpphuIupspPuD.NNQDlSsLVGpVDIpKl-pY.upsDPcAYSasGuLN+uNpGlhEFlEMFKssIKhLHsLLTATQEGsasustphuhlsFsGlIlAHSNEuEWtpF+sN+sNEAhlDRIhllcVPYCL+loEEhKIYEKlLppSplsps.hAPcTL-hhuhFolLoRLpps-pSs	................................................................................................oLpEaLs..lC+pD.oAYAsAuERlLhAIGEP...phlDTup-sRL.S.....R.l.F..............u.N..+.l.I.t.R.Y......P.u.F.......c........-.......F.......Y..G..ME-AIEQIVu.Yh...+H...A.A.Q.G.L..E..E.+K.Q...I..LYLLGPVGGGKSSLAE.+LKpLM.pph..........PIYsL.............................ctSPVp-cP.L....sL......F.sPpE......Du........p........l........L.........-.........c........E.......YGIP....................pRYL.tsIMSP.....W...A....s....K....R...L.....c...E..............F.....G..GD.........I.....o.....+.....F.......+...V.......V......K.......l.........aP........SILpQ...IuIAKTEPGD..E...NNQDISuLVGKV...D...IRKLEc.a..uQ.sDPDA.YuY.S.GuLC+ANQGlMEFV.EMFK...APIKVLHPLLTATQEGNYsGTE.GluA.lPFsG.lILAH..SN..ESEWhoFRNNKNN...E..A..FLDRl.YIV..KVP....Y..C..LRlS.EElKIY-...KLL.pcS.-Ls....c..AsCAPu.TL-sL.............upFSlLSRLKEPENSs...................................................................	1	95	198	277
+8131	PF08299	Bac_DnaA_C		Bacterial dnaA protein helix-turn-helix	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.90	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.02	0.72	-4.12	14	4828	2012-10-04 14:01:12	2005-05-20 13:18:53	6	14	4481	14	1038	3266	2314	68.70	46	15.45	CHANGED	olcpIpcsVA-haslslp-lhScsRs+slspsRQIAMYLs+pLTspSLPcIGctFGGRDHTTVlaAsRKI	.............................l-sIQct.VAcaa.plpl.pDl.hu.p..+R.s.+.s.l.sp.PRQl.A.M.YL.u+EL..T.s.tSLPcIGctFGGRDHTTVlHApcKI..............	0	367	704	891
+8132	PF08300	HCV_NS5a_1a		Hepatitis C virus non-structural 5a zinc finger domain	Paterson M, Bateman A	anon	Bateman A	Domain	The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2]. This domain corresponds to the N-terminal zinc binding domain [3].	20.70	20.70	20.90	21.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.30	0.72	-4.06	19	5702	2009-01-15 18:05:59	2005-05-20 13:58:15	8	39	117	6	0	5232	0	61.60	83	5.83	CHANGED	lPFlSCQ+Ga+GsWcGDGlhpTpCsCGA.IoGcV+NGoM+..lsGP+hCSNhW+GTFPINshTo	...lPFlSCQRGYKGVWRGDGIMpTpCsCGApITGHVKNGSMR..IVGP+TCpNhWpGTFPINAYTT......	0	0	0	0
+8133	PF08301	HCV_NS5a_1b		Hepatitis C virus non-structural 5a domain 1b	Paterson M, Bateman A	anon	Bateman A	Domain	The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2]. This region corresponds to the 1b domain [3].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.02	0.72	-3.66	20	10555	2009-09-11 00:37:05	2005-05-20 14:01:38	8	41	117	6	0	7446	0	68.20	85	10.02	CHANGED	GPusPhPuPNYppALWRVuAc-YVEVpRlGDaHYVsGsTsDsLKsPCQVPuPEFF..TEVDGVRlHRaAPsC+PLLRDEloFoVGLsuaslGSQLPC-PEPDV	...................................................................................PLLR-E.VoFpVGLNpYhVGSQLPCEPEPDV...........................	0	0	0	0
+8134	PF08302	tRNA_lig_CPD		Fungal tRNA ligase phosphodiesterase domain	Mistry J, Wood V	anon	Pfam-B_49998 (release 17.0)	Domain	This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity [1].  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.	21.30	21.30	21.50	21.30	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.89	0.70	-5.17	19	168	2009-01-15 18:05:59	2005-05-20 16:00:11	6	8	142	0	119	174	3	219.00	25	29.09	CHANGED	SShcNlcpVlspL+ptYPpLl...clPosp-lDpAlphAhstY+Pshc+shshsspp.tpp....pp.........................ss.cppp+plcYaulsl.sspclpshLcshhs.s....ss-pt+hacpLhss+RlQspFHVTLIH+AupKp.pP...clWcpYsphahsphpppspsp.............h.shussclcL-+Ll.WDD+lMshlsclh...s.p...........ssa..tCsNplsHITVGThuspVKP+ESN-LLp+ah.......p.tGous-...sGlhphplsGshllpGsVthsh	.................................................................................ShtNhchllptl.t.aP.lh....phPsspphctAhp.uhp.Yp.sphp+.ht.t..t......................................t.pt.h.htp.pYhul..pl....s.pplhphlpphhsss......st.tp.happLhtspRl....Q.ph...HVTLhHpsstpp......p......plWpphhphatt.thtpt..t...............................st...splpL.c.+ll..aDc+lhAlssc.lhs.......................................sph....ssN.p.hsHITlGTtpssVKPhESNcLLpchh........p...sst.t...ttl..h.h.............................................	0	38	71	101
+8135	PF08303	tRNA_lig_kinase		tRNA ligase kinase domain	Mistry J, Wood V	anon	Pfam-B_49998 (release 17.0)	Domain	This domain is found in fungal tRNA ligases and has kinase activity [1].  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.	22.70	22.70	22.70	22.80	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.11	0.71	-4.38	9	141	2012-10-05 12:31:09	2005-05-20 16:00:33	6	7	132	0	106	153	2	160.00	43	19.71	CHANGED	lllPIATIGCGKTTVuhsLpsLFsp.WuHlQNDNI.ouK.sps+hh+psLchL....t+csppsVlsDRNNHph+ER+QLF-.lpph+-pals.s.sl+hlulsFlc.c.phpElh-lThsRVhpRGDNHQSIKspo.stp+VhtIMpGFlKRaQPls.s.+pPDspFDhlIcLclu	.................lLVPIAoIGCGKTTlulALscLF...s.....WGH....lQNDNI.suK.tcs.cFscpsl.phL......tspssVlAD.................RNNHpp+..ERcQ...lhs...slpp.........hp.........................ss...+hlALpa.scps.......lscl+clTtpRVlpRGDNHQTI+..uso...sp..pcl......huIMcGFlpRFpslssp.pp.......P........DstFD.lIcL-..s.........................................	0	32	63	93
+8137	PF08305	NPCBM		NPCBM/NEW2 domain	Rigden D	anon	Rigden D	Domain	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)	21.20	21.20	21.20	21.20	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.65	0.71	-4.23	43	539	2009-01-15 18:05:59	2005-06-23 15:31:28	6	113	262	16	146	530	40	138.50	24	18.44	CHANGED	ss.sssshL...SDlsh..hou....ssGWGslp+Dpus......supsLslsG.........psasKGlGsHAs..SplsYsL.Gst.hspFpAhVGlDcp...hssp..GoVhFpVh...sDG..pplasSss.....hpsssssptl.slDl.....sGspplcLllssuG.su.ssDHusWusA+ltp	.............................................................ss..t..hlo-h.h....ps......tsth.t..s.hp.t..sts..........psp.lplts........hpa..s+.....GlGs.....p.....As.............S......plh.....Yslp..u...t.t...hspFp...uhl.G.lDcp................hssp.......sslpFpVh...........sDG......chla.sSss........hphss...ss.thl..slsl.....pGspplcLhss.s..uG..ss.s.t.t.Dc..ssaussph....................................................	0	74	114	142
+8138	PF08306	Glyco_hydro_98M		Glycosyl hydrolase family 98	Rigden D	anon	Rigden D	Domain	This domain is the putative catalytic domain of glycosyl hydrolase family 98 proteins.	21.00	21.00	21.10	21.10	19.10	20.90	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.11	0.70	-5.73	6	208	2010-01-08 16:43:45	2005-06-23 15:32:49	6	15	206	14	11	93	0	299.60	59	31.09	CHANGED	uhhssssspsss...shRRsISsEpPhhhl.l.u............Wssss.pthh-hIPsDl+PYTVlpLp.u........ls+c-usup......chhEphlEpApSal..KTstspsl.shlps.SuG..chPsYsssspLpos....hh-EhFpcYPNhhGh..sEpaWsassshu.......sHhAphLKLosKYGGYh.......hWusp.NshAhtK.......psssFppAlcpYt+NFIhtpK.TsptshpD..sESlshGhWLSGaAspaGhphDohtWYEpt...........pupGs+pasststAhhhIE..plhLsGtTVash.chhaT.sVpspss...............PtFsNlhh-hFR+lIsssh.	................h.......s...s...thRp.lss-pPhhh..h.s...............................Ws.ss.KGAWEAIPEDVKPYAAIELHPAKVCKPTSCIPRDTKELR......EWYVK.MLEEAQSL.........NIPVFLVIMSAG.....E......RNTVPPE.................WLDEQFQKYSVLKGVLNIENYWIYNNQLA..........PHSAKYLEVCAKYGAHF.......IWHDH.........EKWFWETIMNDPTFFEASQKYHKNLVLATKNTPIRD..DAGTDSIVSGFWLSGLCDNWGSSTDTWKWWEKHYTNTFET...GRARDMRSYASEPESMIAMEMMNVYTGGGTVYNFECAAYTFMTNDVPT................PAFTKGIIPFFRHAIQNPAP......................................	1	6	6	8
+8139	PF08307	Glyco_hydro_98C		Glycosyl hydrolase family 98 C-terminal domain	Rigden D	anon	Rigden D	Domain	This putative domain is found at the C-terminus of glycosyl hydrolase family 98 proteins. This domain is not expected to form part of the catalytic activity.	25.00	25.00	25.00	25.90	23.20	23.90	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.78	0.70	-5.12	3	232	2009-01-15 18:05:59	2005-06-23 15:34:03	6	14	206	9	16	109	0	224.00	53	25.82	CHANGED	KpEVlsRTKuVlasshTp.NGpGpYSS.pshFsGLY......TphsQpPhY.sTGRYssIPsVappID+pKIuSpFPsu.hKllocNSoELSSIssKspYLNuLYPcEYsGDlYAQRlDNoWaIYN.sYNpNKNQpGuFslhhNNsKSLslTLsPHTYuVVcENssuLsIhLNNYRT-KsuLWthutNhDtuKph.chpcl-hhNWl.csY.hNssss-hRToTITLpGtousPThoNlsGD+GcYshsTVsasssT+uhTITVsHNGslDhoIssc	........KEEVlsRTKsVha......NGpG+...hSS.pshapGLY.............oscEshPLY..ssGRYpllPVIa-hlDp-KlushFPsu..KI.......locsSpEhSS...KVsYLNuLYPc..YEGDhYAQRlsNoWalYN.sss.N...hN.........KsQps.hLPhhhN.sscS.LoL-hoPHTYuVVKEps.N..sL+IhLNNYRT-Ksuh.........Wu.utshstuKph.phpchthhpW.IpcpY.hs.......s..ss-hRTTTlTL+Gtoup.s.hslSGD+......NcYsh...T......NaDpssHVhTITVNHNG.lEhoIssp......	0	8	8	11
+8140	PF08308	PEGA		PEGA domain	Mistry J, Adindla S	anon	manual	Domain	This domain is found in both archaea and bacteria and has similarity to S-layer (surface layer) proteins.  It is named after the characteristic PEGA sequence motif found in this domain. The secondary structure of this domain is predicted to be beta-strands [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.30	0.72	-4.19	32	1445	2012-10-02 19:08:27	2005-06-23 15:51:23	6	105	449	0	727	1662	573	68.30	22	20.63	CHANGED	huslslsSsPpGApVhlDG.thhG...pTPh.sls.lssGp+plplphpGYtsappplplp.sscshplphp..Lp.tp	.............................tlplpS.sP.t..u..ApV.h..l....s...G.....p..h..h.G...........pT.....P.......h....p.....l....t...............l..s.....s...G.......p....a..p.......l..p.l.p..t...p..G..Y.p.s..h.p..p.pl..plp..ss.p.p.h.tlpht..................................................	0	322	491	635
+8141	PF08309	LVIVD		LVIVD repeat	Mistry J, Adindla S	anon	manual	Repeat	This repeat is found in bacterial and archaeal cell surface proteins, many of which are hypothetical.  The secondary structure corresponding to this repeat is predicted to comprise 4 beta-strands which may associate to form a beta-propeller [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  The repeat copy number varies from 2-14.  This repeat is sometimes found with the PKD domain Pfam:PF00801.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-8.00	0.72	-4.97	22	449	2012-10-05 17:30:43	2005-06-23 15:54:39	6	46	137	0	309	513	544	40.50	33	8.98	CHANGED	uG.spslsVSGNYAYVA..DtssGLlIVDI...SNPSSPsLpGsasT	..................s.s.ltls..G..s..YAYVA..........s..s.s.sG......Lh.IlDl......SsPssPthhuph............	0	143	204	270
+8142	PF08310	LGFP		LGFP repeat	Mistry J, Adindla S	anon	manual	Repeat	This 54 amino acid repeat is found in many hypothetical proteins. Several hypothetical proteins from C.glutamicum and C.efficiens along with PS1 protein contain this repeat region. The N-terminus region of PS1 contains an esterase domain which transfers corynomycolic acid. The C-terminus region consists of 4 tandem LGFP repeats. It is hypothesised that the PS1 proteins in Corynebacterium, when associated with the cell wall, may be anchored via the LGFP tandem repeats that may be important for maintaining cell wall integrity [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  Deletion of Swiss:Q01377 protein results in a 10-fold increase in the cell volume of the organism and infers the corresponding proteins involvement in the cell shape formation [1]. The secondary structure of each repeat is predicted to comprise two beta-strands and one alpha-helix [Adindla et al. 2004].	20.70	20.70	20.90	20.70	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.56	0.72	-4.33	31	1397	2009-01-15 18:05:59	2005-06-23 16:04:57	6	50	220	0	484	1277	0	52.30	30	25.49	CHANGED	LGhPhu.sEtshsDG.G+appFps.GsIYWsssTGAasl.sGsIhctWtstuhEpG.	.....................LGhPss..s.E.....h.....s...h...s....s...G............u...p.hpp...F.......p......s......G......s....l...a...W..o...s...s.........o....G.....A.a.s..l...tGslhstasphuhttu...........	1	164	343	447
+8143	PF08311	Mad3_BUB1_I		Mad3/BUB1 homology region 1	Mistry J, Wood V	anon	Pfam-B_3330 (release 17.0)	Domain	Proteins containing this domain are checkpoint proteins involved in cell division.  This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p [1].	20.70	20.70	20.70	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.59	0.71	-4.35	25	450	2009-01-15 18:05:59	2005-06-24 09:15:27	7	14	255	13	294	455	1	122.00	31	13.79	CHANGED	lppp+ppaEpclpshp...tDDPLplWhcYIpWhccsaPp....ssppSsLhslLERslptFtcsc+Y+sDsRaL+lWLcYhc..hhs.....-sp-hFpaLhpptIGsplAhaY.paAphLEspspapcAsplaphGl	.....................................h..t.+ptaEtclpthp...ucDPLsha...............c..............YlpWsppsaPp...............tsppstL.hs.lLE+shptF.hsp....p..+..Y+sDsRaL+lWlcahc.hhs........................cspchap....aLhppsIGpphAhaY.paAthhEtp.sphpcAcplaphGl...............................	0	87	150	231
+8144	PF08312	cwf21		cwf21 domain	Mistry J, Wood V, Bateman A	anon	Pfam-B_14400 (release 17.0)	Domain	The cwf21 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe [1]. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding [2]. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.	21.00	21.00	21.00	21.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.27	0.72	-4.11	76	461	2009-10-29 13:58:15	2005-07-13 09:22:44	7	10	268	1	314	448	0	48.80	38	7.17	CHANGED	l-H-++...RcIElKlhEhc-cLE-..cu.....................................h.s---I-p+lsphRp+Lhpchp	............h-H-++...RclEl...Klh-hp-pLE-.....ps.................................................h..spppI..pc+VpphRpcLhpc..t.................................................................................................	0	97	155	240
+8145	PF08313	SCA7		SCA7, zinc-binding domain	Mistry J, Wood V	anon	Pfam-B_21229 (release 17.0)	Domain	This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK [1].  This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7) [1].  Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain [2].	19.80	19.80	20.00	20.20	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.56	0.72	-4.38	17	392	2009-11-18 17:56:09	2005-07-13 09:42:51	7	11	194	2	252	404	1	70.50	44	12.05	CHANGED	s++pccs+p+s.......sps+p.lDl-KQCGV.LPpGt.hCuRSLTCKoHSMGuKRAV.GRopPaDlLLs-ap++sph..K.	...............................................ttp.....................hsct.hD.s+pCGVlsscsp.t......CTRSLT.CKoHShspRRAV.GRpp.aDhLLscaptcsptp.....................	0	62	111	174
+8146	PF08314	Sec39		Secretory pathway protein Sec39	Mistry J, Wood V, Schmitt HD	anon	manual	Domain	Mnaimneh et al [1] identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes.  Kraynack et al. (2005) [2] showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006) [3].	18.50	18.50	19.20	18.60	17.70	18.30	hmmbuild  -o /dev/null HMM SEED	715	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.94	0.70	-6.60	20	278	2009-01-15 18:05:59	2005-07-13 09:48:18	6	15	208	1	202	289	0	559.60	21	47.25	CHANGED	LhLLAsplsspus..lpsLspLhspasuhls.-...lL+IlLohhP.Eoh-PpsYssllppl.psp.sts...............hhsp-shslusscshsssssp+ps..........cphcLlsL+h.tt.ps.t..ss-hlspFLhcRuhcl-p.os.hshhhpL...........Lhshhc...pssplpsWlhusllPLl+h.Nhchh..ts.sholsshpsh.sstsslslLLuhssscpt........lspsLcsllsPalhtppc.pp..hpphhtssshshhpsppp............lhcaLhspuphshtssspuh....s..p.......................ppcaspsuLuslYtss.......csohpsLshshtlhpths.lhthpt..hh.............................shlssss.lshsst.shshhptlLhohphLpphs..hshphhtphh..ps..pctQltchpshlpshhhpppstts...Wpplhpplhhlpsht................hlFsplsp-hlpscllc..sLLpsscas...lAtslhppssst................lssp.lccslhpshashassAoNss+oRsshK+Apch..Lphhssp.......hssss.shpplcsLlpAocsLSpYSL..sLppG.......PFpPlsl...Rh+sDPlulIp+lL-QNP+uYppl-cllslu+pLlpAh.......................sptpccshhsscpRl....huhsIcsALsssDFpsAYshslshLpsss..spp.............t.......c-hsWcssaQsG+YhsPs.sss...pth................LspRhElLShALplsP.s-sLpclLusWpph-pELss..Lhspcpst-sshc	....................................................................................................................................................sh.hs.psp..httl.hh.t.h..............lhs.hP.E.h.....s.tth....hl.......................................................................tt.........h....t....pt.....t....h............................t...ph.h.....t.............................p.h.pah.pRs.tlpp.st....h.t...............l..hhp...........h...th...h.......sh.hh.......h............t......h....slt.h.pph..ts.p.hhphhhp.stt......tp............hsp.hhthhhPah.....http.....................t.........t....................h...hlh.p.......p......h.......................................phht.hsLtshY.st...........p.p.h.ph..tlh.ppls....................................................................thht....s..h.p........t..hp.hpt.......hl...ssphLt.phsh..hshphhtph...........ppp.ht.plh.h.hhtph....hppts.....hs.t......Wtthhpph.hhhpp.s..................asp.ls..phh.t.hhc..uL.L.ps......s...chp...............LAtphh.p..s..s.s........................ls...pp..plVhts.hphassuos.scsphsht.+.....sp.......Lphhssp...........ss.shpc..sLl.pAhtt.L.p.pasl.............................hhPlpl..........R.......h.....pt.......D..................lslIppslppsspsYpp.ppLltlup.Lhhs............................tpp...ttp...tpl....h.h..hlc.tALtttDaphAhths.ph......ht...............................s.s.sW..cs.shphGph..s.........................................ltpR.-lLuhuLth...sP..s.....p....plt......lLs.shpphptp.h.................................................................................................................	0	59	107	161
+8147	PF08315	cwf18		cwf18 pre-mRNA splicing factor 	Mistry J, Wood V	anon	Pfam-B_19718 (release 17.0)	Family	The cwf18 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe [1].	25.00	25.00	25.30	25.10	24.90	24.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.69	0.71	-3.68	31	268	2009-01-15 18:05:59	2005-07-13 09:55:05	7	3	235	0	201	257	0	132.60	35	70.43	CHANGED	usL-ttAhcRKtRLtpL+ph.................................t.ppppptttssspcssphtLphRNYcPcsc.shKtshhsssp...........ssplEcclpcQhctsctt.....cplDLhpLtP+KPsWDLKRDls+KhchLcpRTppAIAcLlR-Rl	..................................................................s.pLpttAhcRKtRLttL+ph..................................................t....ppp.p......tppspppstpp.pLphR.NYsPcsc.shKtthhsssp.............................................sspl.E.cp.lp....cphptsptt..........................cplDLhsLsP+KP...sWDLKRDlscKL-+L-+RTpcAIAcLlR-Rl......................	0	71	107	160
+8148	PF08316	Pal1		Pal1 cell morphology protein	Mistry J, Wood V	anon	manual	Family	Pal1 is a membrane associated protein that is involved in the maintenance of cylindrical cellular morphology.  It localises to sites of active growth.  Pal1 physically interacts and displays overlapping localisation with the Huntingtin-interacting-protein (Hip1)-related protein Sla2p/End4p [1].	25.00	25.00	25.90	25.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.87	0.71	-3.73	21	213	2009-09-11 00:21:46	2005-07-13 11:52:31	6	4	131	0	161	204	0	110.00	38	26.42	CHANGED	DsIDKLDVTGl.aG.GsFHHDGPFDACsPHRN+ssp..sAPVhAFPtDusNsolGG..ssssccsshspsaGpt-.-s.s...................t.sshttstsp.t..s...h..psspl...spFDsps+sE.lHGssThGLGooTFLDGAPAS+uAIpc	..................DhID+LDsTul.a.G..GhFHHDGPFDAssPcRN+psp......tAPl.tAF.....st...D.u.Npsltu........s..p..tht..hu..t...................................................................ss..p...h.u..o.GLssoThl-GsPAs......t......................................................................................................................	0	34	81	130
+8149	PF08317	Spc7		Spc7 kinetochore protein	Mistry J, Wood V	anon	manual	Domain	This domain is found in cell division proteins which are required for kinetochore-spindle association [1].	34.00	34.00	34.00	34.30	33.70	33.30	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.95	0.70	-5.77	15	147	2009-09-13 12:07:19	2005-07-13 15:40:18	6	13	141	0	113	154	0	314.20	25	26.55	CHANGED	l-...........psspschEPIpLp-FLshssI+F.....hplsohcRhpsohss...............pspssshcDhlsAtasslPhLELYp..aSC+EL++hIuEGRcll+plEscThs-NPP.LF+EYhoAss-h+lLMcsQhp.VKoaARLpSKssWYEWRhpLLcGLK-sLtcplpthppDcchLs+p.shlsslhsclpc+psuLccEhssLcplsc-.....hspsDpp-Lpsh+pcLpplcpcIstpppplpELpsclpchsssIpsssppKpphhtcIp-t-+lhccs+saospEIscL+pphptlcphoGaslhuls.......Gsslohsaccp..........lcLsFs.......usapl	..............................................................................................t.tttt.......t.php..lp..Lp-FLshsslcF......hph.....sss+Rppshhst........................ttpshslcchlsA..thhslPhLELYp..auC+ELpphIs..-G+ph..hcplEscs..htpN..PP.LFpE.Y..hs.....u.s..........s-.h....+..h.l....McsQhp.lKsauRL.uKthWYEWR..hpLl..cGLcpsLtcphpthppDtphLs.cptphls.sllsplhpcpptLppEhp.pLpph.spE...........hpssDp..p-Lpph+....pcLtphctc...........lpthppplpchppclpphppp.l..cphspp+pphhppIp...cs-+hh-.cs.+sa.otpElppL+splctLEp.pGhplhphp................u.s.tl.phtappp..........lpl.ht............t............................................	0	40	67	98
+8150	PF08318	COG4	Sec38; 	COG4 transport protein	Mistry J, Wood V	anon	manual	Domain	This region is found in yeast oligomeric golgi complex component 4 which is involved in ER to Golgi an intra Golgi transport [1].	20.10	20.10	21.10	20.90	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.82	0.70	-5.67	14	351	2012-10-02 15:56:29	2005-07-13 15:46:43	7	11	268	0	250	355	4	282.30	26	39.00	CHANGED	LcphpcpLpplFpccFpcAs+spDltplT+aFKLFPLlGtc-hGLshYucYlCphIAscuRphhpss.t.......sptshhaupslhpLF-plupllpsHstllpphYG..sst...hlpllp+lQcEsDhQsulll-pFhDpR+lcchhppIspas...hst.............t........stp.phlsh+-lssllsEhotlhppWslYp+Fhsh+h.p..............hsssp.p.....hphspllpsuphsppl..pcllssFhtLppaahpcSlp+ulpl-ch...............ptps..sSShV-Dlhhll+psLtpslsTuphsslsphlsp.lsphlpsDa.hphhpspl+	.....................................................................................................................................................................................................................lppspppLpslhhccFtpAspp.....tDhsplpRFFKlFPll..G..h..pc.GLpha............upYlsp.ls.tpuc.t........hp.s.ht...........................pp....tshh...aussLohLF-tlupll-sHtsllc..ph.YG.....sp...................hhp.llptLQhEsDhpsth.llcpa.cpR.ph..pphhp.plpp..ht..st.........................................................................-.t...l...s..+.-lD.lLsEhshh.tphphYh+Fltp+htt...................................................................t.pt..............phsphlppst.hspph..pclls.....Y.shppaahccolpKAhtl.Dph.....................................................................................tps.hhoS.hV.DDlhallppsltRuluouphsslsuhlst.hsphL..ps-a.hthlppch...................................................	0	91	145	210
+8152	PF08320	PIG-X		PIG-X / PBN1	Mistry J, Wood V	anon	manual	Domain	Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I [1].  These enzymes are involved in the transfer of sugar molecules.	20.50	20.50	21.30	21.10	19.80	18.60	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.57	0.70	-5.05	22	258	2009-01-15 18:05:59	2005-07-13 15:56:35	7	5	217	0	165	278	0	194.10	24	54.09	CHANGED	pPsGLHPpLplslss.............spssppCplahahpLPpslFhD+YQ.........t..shs.plhhltGtsDLEhP-Yth..ppWGSphLhcltss............................hpsplPLHhRYhcPup..ssh....pslsls.PhlFhuCssc-ss..........htpsPFsph.....shua-shFsscThFaals.p..................ptslplplPhsst.......tshptVphsThlsllluhla....llhplhtt	...............................sGhH..sL.lp.lph..................h.st.ppCpl.hhh...pLPs....slFsD.apLts.......................................Lppcshh...phh.....hltsps...DLEtP..sa........pp.hus.pl.Llplp.ss................................t...pphpsplPlHhRY...hpP....ps...tsuh..............ppltls.Ptl.hhtC.stppst....................ht..sapph..............sh.s.hhtsp..shh.ahp.t.......................hs.tlplPlhph..........phthlp.sThhhhhls.hhlhhtl...h...........................................................	1	43	84	133
+8153	PF08321	PPP5	PPT1; 	PPP5 TPR repeat region	Mistry J, Wood V	anon	Pfam-B_6912 (release 17.0)	Family	This region is specific to the PPP5 subfamily of serine/threonine phosphatases and contains TPR repeats.	23.50	23.50	23.60	23.80	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.16	0.72	-3.97	10	434	2012-10-11 20:01:00	2005-07-13 16:27:50	7	49	269	28	266	410	3	88.60	30	17.10	CHANGED	KlpECcKlV+clsFEcAIul.-cpc+Sls-sl.DlEshsIEs-YsGP+LEsspVTl-FlKchhEaaK.pQK+LH++aAYpILlplcclL+ppPSLV-l	.............................................h..spphlpp.tF.tAIt..............o.h.....h-..th....D.h...-.s..h.........s....l.-c.s...Y.sGP+................L..............p.....................t...............p...............lTh...............p.............Fhcphl.-t.FK..ppK..pLH.++YshpILhps+cllpp.Pohlc.........................	0	82	129	200
+8155	PF08323	Glyco_transf_5		Starch synthase catalytic domain	Bateman A	anon	Pfam-B_148 (Release 17.0)	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.98	0.70	-4.88	179	5560	2012-10-03 16:42:30	2005-08-09 17:08:06	6	34	3850	19	1001	5688	791	204.20	33	44.27	CHANGED	+...lLaluuEs..........sPh..sKoGGLuDVssuLPpAL..tphG.t..-V..cllhPtY.stl.pph.........php.lhp...h............h..........h.hhph.h...........p.slslah.l-s.t.....ha.p....Rss..hY............sa.DsspRFu...hFupAshchhtt.h..........sh.t..PDll..HspDWpTuLl.PhhL+ph.htt.......stoVhTIHN.........lsaQGhas...tphh.th..hsls..........h...pthcahs...........................plshlK.uGlhhuDtloTVSPoYAcEItsst.......hG..GL-slLpp	........................................................................................................................................lh.hs.Eh.............sh......p.GGL.ucsht.u.Ls...t...........t........s..h..c.s....hh..l..h.P....ha....h.t.t.................................h..................................................hth.h.pthh...................................p..Glsh.hh...l...D.....p.h....................ah..p.....................+ss...........hYss....................sah.D.s.t.h..R.Fu...............hh.sp.A..u.l.Ehsph..l........................................sa..t....Dll..h.spD.WH......ou.Ll.Ps..a...L.+th...h.......p................h..............t......s+..........sshsIHN..............lsaQG..hFs..........hp.h...sh....hsLs.............phh........t...s.h...c...a......s.............................pl.sa.h...K...AGl.h..uD+lsT...VSP...hYApElhss.........th.tL-sllp.....................................................................................................	0	340	651	848
+8156	PF08324	PUL		PUL domain	Bateman A	anon	L. Iyer	Domain	The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain.  It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates [2][3].	21.00	21.00	21.40	21.50	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.74	0.70	-5.60	22	406	2009-01-15 18:05:59	2005-08-10 13:17:14	6	21	274	9	297	411	2	256.60	19	36.81	CHANGED	phhPhpphlhhcshshctlhp+lpchNsp.......tchphs-pplss....ltphlpthpps.t........hpthhthhhpllpsWs.sphhPslDllRlhlhp.sss.hh..t.........ss.hsphhtts.ss...................tp.s.hhhslRhlsNhFsssshtthlhspts.........plhstlsshhssh...............spNlplAlATLhhNhulhhhcss.........sh-hph.lluslhp.....htc..pspEAhYRhllAhGsLh....oht.sshtthspt.........shsthhptptp.........hsp.t+hp-lsp-l	..............................................................................hhP.pphl.hh..cp.s.s.h.ptlhpKl.t.chNtt............tphth...sp..splpt.......ltphl.p.......thpps.ss.....................hpt.h.h...hl.hp.hhtpW.P......s..h..h.hPslDll.Rl.hlh.psp....s.ss..h.hspt..................tphhtphhp.t..s....p...................ss.stthl.slRhhsN.hF.......s..s....tthp.......phhhsptp...............tl.hstltt.htss..............................spNlplAhuTLhhNhulhhpppp........................stctphtll..uslhp..................lhpt..tp.s......Euha.RhLlAlGsLl..........sss.sphhphsps........hth.t.thh.tthtp...................hsp..hhtphht..........................................................................	0	103	168	244
+8157	PF08325	WLM		WLM domain	L Iyer, Bateman A	anon	L Iyer	Domain	This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases).  These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.38	0.71	-4.42	23	403	2012-10-03 04:41:15	2005-08-10 14:50:09	5	13	219	0	290	2217	499	191.90	27	49.79	CHANGED	spstphphLp....pt.PscscALchLp+lAsp..lpslM+c++a+VshLsEhhPppts..................LLGhNhN+Gpc..................IpLRLRsss..ppFlsacslhsThLHELsHslausHDppFacLhcpLps-htplphth.......thhssG+pluupshh.s...............tth.httsthtGtsppLG.Gss...................................................................................................................ssstshRchhutAA-+Rhp	.......................................................................................................................................................l......hPp.tppAhphLc+lAst..lpslM+.c+.papVshLsEh.Pp.pts.......................................lLGhN.....h....N.pGpp............................I..pLR..L.Rsss.......pta.h...shc....p..lhp.T.h.lHEL...sH.......s..l..aus..Hsp.pFa....sLhs.p.L..p..c..Ehp..pl..t..h..p..................h..stG.ppLustth.......................................t..ttthhts..ts...hLG...Gss..............................................................................................................................................................................................tshshRphhAtAA.pRh..........................................................................................................................................................................................	1	97	176	251
+8158	PF08326	ACC_central		Acetyl-CoA carboxylase, central region	Fenech M	anon	Pfam-B_2008 (release 18.0)	Family	The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (Pfam:PF01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyses the rate-limiting step in this process.	18.50	18.50	18.60	18.60	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	708	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-13.13	0.70	-6.42	37	703	2009-01-15 18:05:59	2005-08-10 14:56:40	7	35	365	6	377	673	13	529.70	28	30.19	CHANGED	sLDDPS+V++....ApPFpGpL..PchusPshh.G....sKstp+apthhss...............LpsILsGY.......phhhss.slppLlpsLcsscLPa.paptphSsLtsRlP.pLcptlpphhcchptp....tsp........FPu+pLppllpphhs...hss.....hhthsltPLhplhppYpsGlpsHthslhtsLlccYhsVEplFs..sspp--VIhcLR-cpcsDlpcVlphlLSHuplssKNpLlLulL-ph.ps..................sssthcssLp+lspLps+stu+VAL+ARElLlpspLPSlcpRpsplcclLpu..shhpsthGp.......h.p+ptsph-hlc-LlsSphsV..hDlL.spFF..scsDthVphAAlEVYlRRu.....YpuYp.ltc....lpacpps......slhpWcF..lsp.t.sphst..........................................p..chtshoshohhspptpt......RtGhhlshcpL-clpphl.stuLcthsp.......................tt...t............t.p.....sp.sNlhslsl.........pphpsh..s-p-llsclptllcppc..pcLts.tulRRlTFlhsp.pc...............uphPpaaTF+..uss.......YpE-phlRHlEPuLAapLELsR..Lp.sFclp.l.opsRplHlYpus..........................uKp.........sssD+RaFhRullRsupl..psphsht-hL.uEss..............Rlhs-hLDsLElhsss....poDhNHIFlNhss.hpl....................sspplEtuhsshlcRaGpRLaRLRVspsElRlhls....sssssshPlRsllsNsSGaslps-lYtEhcssp.u............phla+Shs...c.Gs.hH	..............................................................tLDsPotVpt.....sp.a.u..h.......P...t.......h..s..............tp..phht..hp..........................h...lhtGa....................................t.....hpt.hlpphh.sLc...sspLPh.phpt.hssltsRhP..lpt.hpt.ht..t...................................................................................FPup.l.thhpt.ht................................htslhplhp.pattG.t.......h.......h.hh.tlhppYhpVE..p.Fp..................p...ppsl.tl.Rpp..p....s.httVhphhhSHttlttKs.Llhhlhcth............................................................st.hhs.L.ch.spLp..p.pt.......s...cl...uLcApp...........l.L.tsthsphc....spht......p.h....p...h......t..................................................p..hpcll.u.hsl...D.......h.L...hF....pts.....hlt.t.shEs..YlRRh.....Y.sa..ltt......hpht...................hh.apF.....t.................................................................................................................................................................+hGhhh..hp.hpth..........t......h.sthht.h............................................................................................................................................................tp..thhplsl................................t...pt.....ptp....thht.htthhpp.p..t.Lht.ttl+clohhhtp...p.....................tthPtaaTF+.h.s......................................atE-phhRclEPsluhpLELsR..hp..pa...plp.h..st.s...c...phHlY.uh..........................................................................................u+............tshDhRhF....hRullR...p.sph..............hsc..sshphh.sEsp................................Rhl.phh-tL..E.l.h......p.........p..........................p....s.ch....NHlalsh....h.....s.....h.h...........................................sstplcp.htthh.phG.Rhh+LpVhthEl+h.hp..........s.ss.s.hshRlhlsN.oGahh...phphYhEhps.p..t.......p.hhapuhs.......u.................................................................................	0	139	213	317
+8159	PF08327	AHSA1		Activator of Hsp90 ATPase homolog 1-like protein	Fenech M	anon	Pfam-B_4145 (release 18.0)	Family	This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38, Swiss:O95433). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity [1]. It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress [2]. p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport [3]. It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family (Swiss:Q8XY04 and Swiss:Q6MH87).	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.83	0.71	-4.02	114	4271	2012-10-02 19:24:03	2005-08-10 15:01:15	6	39	1661	63	1665	4537	461	127.90	18	71.07	CHANGED	ssss-pVacuhTcs-tltp.W............hs.hph-h...+s..GG.paph.........tst.hstpsp...........hhcltssc+lshs.atht..t..........................httlshplpp.tsss..Tclphpp..........sshstspttp.............hptGWpphl.cpLpphlp	........................................................ss.cpVacs...hos.schl....tp...W......................h.t...tph.-h.............cs......G.G....pa.ph................t...tst..t.h.s.h..p.sp...................hhcl..p.s..s.........c..........p....lshs..htht......t...................................................ts.tlp.hp...h..p...p.....p.......s.ss.......Tplp.hpp....................sshst...ppttt.................httGW.pthl..spLpthl.................................................................	0	625	1111	1404
+8160	PF08328	ASL_C		Adenylosuccinate lyase C-terminal	Wuster A	anon	Pfam-B_1176 (release 18.0)	Family	This domain is found at the C-terminus of adenylosuccinate lyase(ASL; PurB in E. coli). It has been identified in bacteria, eukaryotes and archaea and is found together with the lyase domain Pfam:PF00206.  ASL catalyses the cleavage of succinylaminoimidazole carboxamide ribotide to aminoimidazole carboxamide ribotide and fumarate and the cleavage of adenylosuccinate to adenylate and fumarate [1].	34.10	34.10	34.10	34.50	31.90	32.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.38	0.71	-4.24	107	1767	2009-01-15 18:05:59	2005-08-10 15:17:40	6	8	1709	11	421	1259	659	115.00	62	25.35	CHANGED	SRaQRDLTDSTVLRNlGVuhGaollAYpuhl+GLsKLplNpsplspDL-ssWEVLAEsIQTVMR......RaGltpPYEpLKcLTR..Gp.plstcslppFI..csLc.lP-psKscLhtlTPssYl	.......SRWQ.....RDLTDSTVLRNLGVGlGYuLIAYpSoLKGluKLElNcs+Lhc-LDpNW.E.VLAEPIQTV....MR......RYGIE+PYEKLKELT.R...GK..clssEuh+pFI-u...Ls...lP--.....t..KsRL+uhTPAsYI........................	0	122	261	354
+8161	PF08329	ChitinaseA_N		Chitinase A, N-terminal domain	Fenech M	anon	Pfam-B_1049 (release 18.0)	Domain	This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [1,2]. It is separated by a hinge region from the catalytic domain (Pfam:PF00704); this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution [1].	21.20	21.20	21.20	21.30	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.58	0.71	-4.38	43	378	2012-10-03 16:25:20	2005-08-10 15:19:53	5	25	265	36	56	351	4	122.60	40	18.18	CHANGED	sAsPGsPoIc......Wu-.psaul.....Vclsp..pAT.uYppLVph.c-tlsVsVoWNlWSG-sG-puplhhDGpp......Va....pGsus..sppA..shplspGGpapMpVcLCNu-G....CSsSs.ssplllADTDGSHLtP.L.h..shpENN+saspps	....................................t.PshPsls...aup...pphth..lpls...tsT..uYpphVph.+-tssloVsaNhWo..Gs.sGsoh+lhhsGpp......Vh.......oGsss....upsoA.....sFph..s..KGGpYQhplcLCNusG....Cop.Ss.sscI.slADTDGSHLtP.Lph..slt.NNKsap...s..................	0	13	26	38
+8163	PF08331	DUF1730		Domain of unknown function (DUF1730)	Wuster A	anon	Pfam-B_1023 (release 18.0)	Family	This domain of unknown function occurs in Iron-sulfur cluster-binding proteins together with the 4Fe-4S binding domain (Pfam:PF00037).	21.40	21.40	21.50	22.20	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.50	0.72	-4.31	57	2383	2009-09-10 21:15:36	2005-08-10 15:23:48	5	19	2359	0	510	1721	810	77.80	37	21.12	CHANGED	RscPptLlPss+SlIuluhsYhs.......tshpssppuhlo+Yuh.G+DYHcll+c+LcpLuphlppps.sch..t.....h+shVDo	............................RscPctLlPustslIulths....Yhs...................t....s.............................p............s..l..............p...s.....scp.....GhlSRYAh....G.....+..DYHcllRpRLccLuc......h......I......p....p....cs....s.sh......p..............h+sFVDo...........................	1	151	311	421
+8164	PF08332	CaMKII_AD		Calcium/calmodulin dependent protein kinase II Association	Wuster A	anon	Pfam-B_1025 (release 18.0)	Family	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII).  These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1].  The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.49	0.71	-4.24	7	782	2012-10-03 02:27:24	2005-08-10 15:27:36	5	6	295	44	244	1086	152	118.40	52	32.17	CHANGED	ccpEIlplT-pLlcAIssGDacsYo+lCcsshTsFEPEAhupLl-Gh-FH+FYFE.hhupps+slppslLsP+V+llGD-uAshAYl+LhQhhDcsGhs+ohQupETRVWp++sG+WpsVHhHRSuus	....................................................................................RKQEIIKlTEQ.L.IE.A....ls.sG...D...FE...uYsKl..C..D..P..s..h.TuFE...P.EA......LG.......N.L.V.E.G.h.DFH.......+...F....YFE...N.h..L.u.....K..s.......s..K.s....l.....+.T.....hI..L..N..PHV....H..l.l..G-.-..u..A...C.I.A...Y..l.....R..l..T.Q..a..hD.u...........p..G.hs..+.o.sQ.S..EETR.VWH....R....R....D......G.....K.....W..VHaHpSusP......................................................	0	55	91	151
+8165	PF08333	DUF1725		Protein of unknown function (DUF1725)	Fenech M	anon	Pfam-B_2110 (release 18.0)	Family	This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.32	0.73	-6.56	0.73	-4.47	24	244	2009-01-15 18:05:59	2005-08-11 08:45:36	6	30	26	0	135	164	33	19.60	62	2.50	CHANGED	hpFhGKWMELEsIILSElsp	......FsssWM-LEsIhLSEloQ.....	0	2	8	20
+8166	PF08334	T2SG	GSPII_G;	Type II secretion system (T2SS), protein G	Fenech M, Desvaux M	anon	Pfam-B_1144 (release 18.0)	Family	The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria [1,2]. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme [3]. Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet [1].	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.56	0.72	-4.30	175	1599	2012-10-03 10:38:27	2005-08-11 08:56:08	6	8	1122	10	474	1149	368	105.00	40	69.58	CHANGED	plhs.......ph-....cA...+hpsAcsplpslps.AL-hY+L.DsGpYPospp.GLpALlptPsst...ppa.pGsYl..cplP.pDPWGps...YhYh..sPG....t..p.G.thDlhShGsDGp.GGpu.suDIssW	................plhuph-+ActppAh.sDI..s.s...Lcs.AL-hY...........+............L....D..........N..G.c...............Y.P..o....s.p......Q...GL.c.A.Ll..ppPss................spsa..ps...uYl....++L.P..pDPW..Gss............YpYl....sPG............p.....c.....G.thDlaS.hGsDGp..GG-s.stDIssW.................................................................	0	154	301	395
+8167	PF08335	GlnD_UR_UTase		GlnD PII-uridylyltransferase	Fenech M	anon	Pfam-B_2147 (release 18.0)	Family	This is a family of bifunctional uridylyl-removing enzymes/uridylyltransferases (UR/UTases, GlnD) that are responsible for the modification (EC:2.7.7.59) of the regulatory protein P-II, or GlnB (e.g. Swiss:P05826, Pfam:PF00543). In response to nitrogen limitation, these transferases (e.g. Swiss:P27249) catalyse the uridylylation of the PII protein, which in turn stimulates deadenylylation of glutamine synthetase (GlnA). Deadenylylated glutamine synthetase is the more active form of the enzyme [1]. Moreover, uridylylated PII can act together with NtrB and NtrC to increase transcription of genes in the sigma54 regulon, which include glnA and other nitrogen-level controlled genes [2]. It has also been suggested that the product of the glnD gene is involved in other physiological functions such as control of iron metabolism in certain species [2]. The region described in this family is found in many of its members to be C-terminal to a nucleotidyltransferase domain (Pfam:PF01909), and N-terminal to an HD domain (Pfam:PF01966) and two ACT domains (Pfam:PF01842) [3].	20.50	20.50	20.50	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.78	0.71	-4.35	122	5858	2012-10-01 22:14:54	2005-08-11 08:58:32	6	24	2142	3	1374	4628	1176	134.10	23	21.87	CHANGED	chhctplpcp........tpR+..........tphs..........t.NlK.G.GGlRDlchlh.ltphhh.............thpsLptLhpt.....uhlspp..-hppLpcuhpFLhplcptL.phlss+pscpLs..h-......tptplAph.h....G.................a.............sshtu...ahpphhpttppVpphhphlh	..............................................................hptpl.ppp.................ht.c+...............tt.p................slKhutGGlRDIEalsQ..lh..p..Lhautp..tl.........p..sslpsL.ptls..ph.......uhl..s..pp...-s.tpLp...cuap...hL..pc...l..c...p..t..L...ph....h..t...s....c....t..s....p..t.L....s.......................t..tl..A.h.h...s....................................h.....................ts..t.....hhpth.hthhppltth.p.h..................................................................	0	366	832	1128
+8168	PF08336	P4Ha_N		Prolyl 4-Hydroxylase alpha-subunit, N-terminal region	Fenech M	anon	Pfam-B_2013 (release 18.0)	Family	The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase [1-4]. The function of the N-terminal region featured in this family does not seem to be known.	22.70	22.70	22.80	23.90	22.30	22.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.56	0.71	-4.34	57	702	2009-09-11 11:25:59	2005-08-11 09:00:04	6	15	93	0	369	644	0	123.70	30	26.34	CHANGED	oSlsphpcLlphEcpLlssLcpYlpt.pp+lcpl+phhpphcppppputp..chppYlusPlNuFtLl+RhppDW.pl..cphhpps.hspp..hlptlpphtp....ph.Popc..DlpsAspulhRLQssYpLpspclApGh.lsGh	................oShsphpcLlthEppL.lpsLcpYlpt.pp+lppl+.......ph...hp.....phct...........pp..putp...s.ctal....upPlNAapLl+RLpsDW.pl..cphhtps....spt.......hlss.lp..pp......hh.Ps..p-..DhpuAupuLhRLQcsYpLcspslupG.l.G.........................	0	106	122	259
+8169	PF08337	Plexin_cytopl		Plexin cytoplasmic RasGAP domain	Fenech M	anon	Pfam-B_3123 (release 18.0)	Domain	This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytoplasmic region, which has been called a SEX domain in some members of this family [3], is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [4]. This domain acts as a RasGAP domain [5].	20.10	20.10	20.10	20.60	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.65	0.70	-6.19	11	880	2009-01-15 18:05:59	2005-08-11 09:05:10	7	64	115	19	421	669	1	437.30	47	33.18	CHANGED	uGIPFLDY+sYshRlFF...........................sGpcsHPlhtchp....ttppsslEpuLshFusLLNsKsFLlsFIHTLEpQ+sFShRDRsplASLLhlALpuKLEYhT-Il+sLLsDLI-ps..sK.pPKLMLRRTESVVEKMLTNWMSlCLYsaL+EssGEPLahLapAIKpQl-KGPVDAlTGcARYTLNE-+LLR-slEa+slsLp..........sl..htscss-u........lsV+VLsCDTIoQVKEKlL-slY..KssPaSQRPcsc-lDLEWRsGptu+llLpD.-DlTohhEst.WK+LNTLtHYpVsDGAoluLssp....sshp.s....................hssssssstpttsh.sc..ps................+haHLV+PpD-.s-.....pp+ucRts...............+sKslsEIYLTRLLoTKGTLQKFVDDLFpoILSh..hspslPlAlKYhFDFLDEQA-p+GIoDPDslHhWKoNSLPLRFWVNllKNPQFVFDIcKosphDACLSVIAQTFMDuCShSEa+LGKDSPoNKLLYAKDIPpYKchVccYY+cIpphsslS-QEMNuhLAE.S+tHss-FsshsALpELYpYlpKYtppI	..........................................................................................................................sIPaLDY+sYs.RlhF..................................................s...u.h.psp..l.h.tchc............t.tt.ph..-puLt.hupLlssK.....hFLlpF..I+TLEtQ.+...sFShRD..R.s..lASLlhh..sL..p..u+hEYhTslh+pLL.-Lh-p...sK..pPKL..hLR.R..T...EoV.sEKhLoNWhohh.....Lap..aL+..................-s.........sGEPLahLapAIKpQh-KGPlDulTscA+YoLs-stLl+p.pl.-apsl.s.lp.............................sl.......ts...t.s...t.................ls.V+l.LsCDTIoQlKEKlL-tla..+shPhSpp.Pp.s.ts...h....-L...............EW..RtG......t.h.......s...p.....hlLpD....D.......h.T........o.h.......h.pst...WK+L...NTL......tHY..p...V..s-...u...u.s.lsLs.p........p...............................................................................h.t.tp.p......t..p.p....t....s.h....p.......pt.......................+haH.LV+s.p..-c....c..........thcscR........................tsKhl.sEIYLTRLL..u.....sK.G.TLQpFVDDhFpslhS.........s.p..s..lPhAlKYhFDFLDE.QApp...+..t.I.p.D.......-shHh.WKo..N..sLPLRF....WVN.llKNPpFlF.Dlc..psshsDAsLSVlAQTFMDuCoho-H+..LG.............+...............DSPoNKLLYAK-IP.pYKp........h...V-..cYYtsItphs.slS-Q-MsshLsE...S.......+....a..ts.ph........ss.sALpElY.p.Y.hpKYh-pl........................................	0	104	131	262
+8170	PF08338	DUF1731		Domain of unknown function (DUF1731)	Wuster A	anon	Pfam-B_1045 (release 18.0)	Family	This domain of unknown function appears towards the C-terminus of proteins of the NAD dependent epimerase/dehydratase family (Pfam:PF01370) in bacteria, eukaryotes and archaea.  Many of the proteins in which it is found are involved in cell-division inhibition.	20.40	20.40	20.40	20.90	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.09	0.72	-4.47	150	2466	2009-01-15 18:05:59	2005-08-11 09:12:23	6	12	2252	1	619	1759	633	48.10	39	15.43	CHANGED	lP..uhsL+...lllG.Ehu.pllLpuQ+VhPp+LhpsGFpFcassLcpALpsll	..............lPuhsl+....llhG..Ehu.tLlLsGQ+slPp+L.p.p.s.GFpF+assLcpALpsl...........	0	205	395	534
+8171	PF08339	RTX_C		RTX C-terminal domain	Fenech M	anon	Pfam-B_2178 (release 18.0)	Family	This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli (Swiss:P09983) and Actinobacillus pleuropneumoniae (Swiss:P15377). RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes [1]. This region is found in association with the RTX N-terminal domain (Pfam:PF02382) and multiple hemolysin-type calcium-binding repeats (Pfam:PF00353).	30.20	30.20	30.20	30.70	30.10	29.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-11.04	0.71	-4.48	11	230	2009-01-15 18:05:59	2005-08-11 09:14:43	5	17	136	0	4	184	0	136.40	36	15.23	CHANGED	shSDhshcDlsFc+VscsLll...........pNs+psplTIpsWFccushup............pscKIEpIlsKsGc+ITScpl-cllp.cscGp.IptpsLsp...................hu-sath......t.ptsslsNslsKlISSsuuFsoup....sptsuhh..lsosths...phpohpLApAA	........phSDlshcDlsFcRlssDLlh...........psscts.s.lThpNWFtcss.ut...................................ps+pIEpIhsKsGccIss-pls+hhp.ptss..htsptlup......................pp..s........shsslsNslsKlISSsuuFsos.....spthush..ls.pt.ss....ppuhpLsps...............................	0	0	0	4
+8172	PF08340	DUF1732		Domain of unknown function (DUF1732)	Wuster A, Eberhardt R	anon	Pfam-B_1065 (release 18.0)	Family	This domain of unknown function is often found at the C-terminus of bacterial proteins, many of which are hypothetical, including proteins of the YicC family which have Pfam:PF03755 at the N-terminus. These include a protein important in the stationary phase of growth, and required for growth at high temperature [1]. Structural modelling suggests this domain may bind nucleic acids [2].	20.50	20.50	20.70	21.50	20.20	19.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.88	0.72	-4.16	157	2499	2009-01-15 18:05:59	2005-08-11 09:16:42	6	3	2472	0	580	1771	606	85.80	52	29.77	CHANGED	tQElslhApKsDlsEElsRLpoHlsphcchL.p...s...........s...............s.lGR+LDFLhQEhNREsNTluSKus.....shplophsl-lKs.lEphREQlQNlE	......QElslhAp+hDlsEELsRLcuHlpphpplL.cp...p........t........................slGR+LDFlhQEhNREuNTluSKS.......ss-lostul-LKslIEQhREQlQNIE..........	1	207	385	489
+8173	PF08341	Fb_signal		Fibronectin-binding protein signal sequence	Wuster A	anon	Pfam-B_4004 (release 18.0)	Family	This domain is found near the N-terminus of fibronectin-binding proteins in Streptococcus where it functions as a signal sequence [1].	25.00	25.00	25.50	26.00	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.95	0.72	-3.97	30	227	2009-01-15 18:05:59	2005-08-11 09:19:11	6	21	39	6	11	210	0	74.20	35	16.57	CHANGED	PaYGY-uhss.h........tYHcLcVs.LpGo.+pYp..VYCFNlc+p.P.cspuhspsa.............Yc+l-Gss.psFppYAtsPR	................saYGYDshssh...........pYHcLpVs...lpGo..csYQ.....VYCFNls+phPpsspu.hspsh.............YKKlcGos.psFppYAtsPR.....	0	0	2	8
+8175	PF08343	RNR_N		Ribonucleotide reductase N-terminal	Wuster A	anon	Pfam-B_1066 (release 18.0)	Family	This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyse the formation of deoxyribonucleotides [1]. It occurs together with the RNR all-alpha domain (Pfam:PF00317) and the RNR barrel domain (Pfam:PF02867).	20.80	20.80	20.80	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.75	0.72	-4.17	65	2010	2009-01-15 18:05:59	2005-08-11 09:27:31	5	10	1914	6	245	1190	16	80.30	42	11.63	CHANGED	YhpLNspl.Nl.spsGplp.hcKD+EAlcsahpppVpsNThhFsSlcE+lcYLlcp.sYYEpphl.cpY...shsalccLachAaupcF	..............YatLNs.l.NhhsssGpIp.h-KD+EAlcuahtppVps..NTl..hFsShpE+lsYLlcc.sYY-pshl........scY.......shsFlpcLapaAcspsF...........	0	53	132	191
+8176	PF08344	TRP_2		Transient receptor ion channel II	Wuster A	anon	Pfam-B_1032 (release 18.0)	Family	This domain is found in the transient receptor ion channel (Trp) family of proteins.  There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors [1].  This domain does not tend to appear with the TRP domain (Pfam:PF06011) but is often found to the C-terminus of Ankyrin repeats (Pfam:PF00023).	20.90	20.90	20.90	24.10	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.07	0.72	-4.04	18	680	2009-01-15 18:05:59	2005-08-11 09:37:35	6	28	108	0	347	603	0	62.10	55	7.46	CHANGED	CsCs-C.ptpppDSL+HSpSRINsYRALASPuhluLo...ScDPlLoAFcLSaEL+cLuthEpEF+	................CpCs-.Cspp.pct.DSlpHSRS.RlNsY+uLASPuhluLS..............SEDPlLTAFcLStELpcLu....plEpEFK.............	0	97	125	217
+8177	PF08345	YscJ_FliF_C		Flagellar M-ring protein C-terminal	Wuster A	anon	Pfam-B_1149 (release 18.0)	Family	This domain is found in bacterial flagellar M-ring (FliF) proteins together with the YscJ/FliF domain (Pfam:PF01514).	19.20	19.20	19.30	19.30	19.10	17.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.08	0.71	-4.27	169	2282	2009-09-10 21:18:48	2005-08-11 09:40:36	6	5	2017	0	541	1738	450	168.80	31	31.19	CHANGED	LpsllG..s..ssp.spVss-lDFsptppspcpa........cP...sp...........tsl.RSpps.pEss..ssst...sss..G...lPGshoN...h..Pss...........................sssts..sss...................................................t..................sscpcps....pNYEls+shppspp.ssGplc..RLSVAVll.st..........t....................t..thtshssp...clsplpsLVpsAlGas.....ts..................RGDs.......l.sVsshsF	.................................................LsPllG.ss.ph+.spVsspl.DFspp-popEpY........sP.....st.............ssl.RScQp.p-sp....pust.....hssG......lP.GuhS.Np.....Pss.......................s......tts...........................................sp.............ssc..pppTpNYEl..s+ol.pcscp..ssG.s..lp..RLSV.AVl.V..st..................................p...................psp.hsh.osc...phpp....l..csLlpsAh...Gas.......tp.......................RGDs.......l.sVsshsF..............................................................	1	175	342	438
+8178	PF08346	AntA		AntA/AntB antirepressor	Wuster A	anon	Pfam-B_2097 (release 18.0)	Family	In E. coli the two proteins AntA and AntB have 62% amino acid identities near their N termini. AntA appears to be encoded by a truncated and divergent copy of AntB.  The two proteins are homologous to putative antirepressors found in numerous bacteriophages, such as the hypothetical antirepressor protein encoded by the gene LO142 of the bacteriophage 933W [1].	20.50	20.50	20.60	21.10	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.65	0.72	-3.78	57	810	2009-01-15 18:05:59	2005-08-11 09:43:36	7	14	597	0	102	564	4	70.80	41	31.26	CHANGED	VsAR-LHphLcl.ppcFssWhctRhpcYs.FhEs.DFhsh.p.....................tpspuu+............phDYtlTLDhAKEluMlpRs	..............lsAR-LHphL......pV..ppcFssWhc.Rh..p...cYG.F.tEstDah..shpp..........................ht.s.tts..us+...........ptpDYtLTLDhAKElAMlpRs......................................................................	0	22	65	79
+8179	PF08347	CTNNB1_binding		N-terminal CTNNB1 binding	Wuster A	anon	Pfam-B_2064 (release 18.0)	Family	This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (Pfam:PF00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation [3].  Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation [1,2].	22.40	22.40	22.40	22.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.81	0.71	-4.06	18	496	2009-01-15 18:05:59	2005-08-11 09:47:26	6	5	89	10	161	406	0	168.80	45	42.31	CHANGED	MPQLs.....uuGGD.DLGAsDEhlsFKDEG-.p-EKh...sENs.s.tD....Ls-lKSSLVsEoEsspssss................cth......................pRpsps.h....sa.-c.tc+h-p.s+ppp..shGhh.+s.sYs........uas.hhhh......sps..sNGohuP......................................uNKlsVlpss.th.s..LsPLhs...Yss-Hao.GsPP....shhPs-l.ssKs....Gls.RPspss-lsshYPLssuthGQls...asl.sW	.......................................................................................stsuD.-LsusDEhh.FpDE..Gt.pp-......tt..........L.s-.KSSLls.oE...ts.........................................................tct..s............a...t...p.....tt..tt......s..uhh..+sssYs........uas..hhM.............t.shh...ssuu.SPs.............................................................................................................SNKVPVVQ.sHtV.HP..LTPL.IT........YS.sEHFo..PG.s.P..........sHlPsDl.ssKp....Gls.RsPpssDlSsaYPLSPGsVGQIs...aPLGW..............................................................................................................	0	24	37	88
+8180	PF08348	PAS_6	YheO; 	YheO-like PAS domain	Fenech M	anon	Pfam-B_2023 (release 18.0)	Domain	This family contains various hypothetical bacterial proteins that are similar to the E. coli protein YheO (Swiss:P64624). Their function is unknown, but are likely to be involved in signalling based on the presence of this PAS domain.	21.10	21.10	21.10	21.30	21.00	20.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.58	0.71	-4.54	36	1856	2012-10-04 01:10:46	2005-08-11 09:50:25	6	5	1451	0	282	973	28	116.10	38	51.45	CHANGED	lLpsatsls-uluphhGspsEVVLHsL..cs.csolltIsNscloGRplG.sPhTph........uLctlpp.t..pppshtsYhspstcG.+hl+SsohhI+sspschlGhLCINh....Dlsshpth.pphLpt	........Lcsapsll-GLutll.Gsp.CElVLHsL..p....c..h..csShltIsNGchTGRplG.uPl.T-l.........AL.chL+c.....hp........cp..s......s...p...sYh....o+spsG.tlhKSsTlhI+s.c.ct.+.lI.GlLCINh..slss.h...pph...h..........................	0	69	132	209
+8181	PF08349	DUF1722		Protein of unknown function (DUF1722)	Wuster A	anon	Pfam-B_4169 (release 18.0)	Family	This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.	21.20	21.20	21.30	21.40	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.20	0.71	-4.22	94	1436	2009-01-15 18:05:59	2005-08-11 09:51:49	6	6	1379	0	231	801	53	115.00	35	49.27	CHANGED	KhlLMAHs.ptY+pLGpllAshpphs.hcphhppYtptlMpALpphAoppspsNVL.HlhGYFKcpLssp-Kp-lhclIppYRpGhlPLlsPlTLL+Halpcas..ssYLtpQs.YL.pPaP	......................KhhlLAHSQstY+cl.GthlAsh.......ppht..l-shhppYppplhthLpcssohpspsNVL.Hl.GYF+ppls..spE+ppltpLIpp.YRpG.p.h.PlhsPL.shlKcahscYP..ssYLtpQpYhp.a.........................................	0	62	133	183
+8182	PF08350	DUF1724		Domain of unknown function (DUF1724)	Wuster A	anon	Pfam-B_1158 (release 18.0)	Family	This domain of unknown function has so far only been found at the C-terminus of archaean proteins, including several transcriptional regulators of the ArsR family (see Pfam:PF01022).	20.50	20.50	21.90	20.50	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.04	0.72	-4.44	67	138	2009-01-15 18:05:59	2005-08-11 09:55:08	5	7	40	0	120	138	7	63.20	29	23.56	CHANGED	Nsclalh.psslcl.uhs.VTDcahsLuLFscsGp.aDp.ptllSa-spAlpWGcELFpaY+ppucpl	..........Nhplalh.ppslcl.uhs.VTDchhhLuLapc....sGp.aDp..ptllSh.....-ppAlcWGp-LFpaYcppup.......	0	36	69	82
+8183	PF08351	DUF1726		Domain of unknown function (DUF1726)	Wuster A, Eberhardt R	anon	Pfam-B_3131 (release 18.0)	Family	This domain of unknown function is often found at the N-terminus of proteins containing Pfam:PF05127. Its fold resembles that of Pfam:PF05127, but it does not appear to bind ATP [1].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.71	0.72	-4.30	42	1117	2009-01-15 18:05:59	2005-08-11 09:57:59	6	15	1047	2	384	869	19	91.60	36	11.76	CHANGED	Yp-oc+l...LGpTashllLpshcslpPNhluRhl-sVcGGGllllLhsshpphcphhs..............................shcpph...hs..sat..clhtpFpcRFhtpLtpp.cshhlhD	..........pplLGppaphsVhDs.h...c....uhsssshAthsGTlcuGuhllLLls.s.h..pphcph.s..............................ssphRa...psp.sps........ss..s+Fsp+hh.psLsss.ppsh.............................................................	1	121	208	310
+8184	PF08352	oligo_HPY		Oligopeptide/dipeptide transporter, C-terminal region	TIGRFAMs, Fenech M	anon	Pfam-B_3025 (release 18.0)	Family	This family features a region found towards the C-terminus of oligopeptide ABC transporter ATP binding proteins, immediately following the ATP-binding domain (Pfam:PF00005). All characterised members appear able to be involved in the transport of oligopeptides or dipeptides. Some are important for sporulation or antibiotic resistance. Some dipeptide transporters also act on the heme precursor delta-aminolevulinic acid.	21.00	9.90	21.00	9.90	20.90	9.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.38	0.72	-3.62	59	28166	2009-01-15 18:05:59	2005-08-11 09:59:58	7	33	3987	0	6863	20640	4857	55.40	33	17.52	CHANGED	VEhGsspplh..psPtHPYTptLlsuhPphsstpp...........htuphP..shtphsp..................G..ChFtsRCshspst.C	...............VEtGs..sccl..a....ps..P..p......HPYTpuLL..u..u....l..P..p...hsst..t.....................h....t................................................................................................................................	0	1910	4134	5534
+8185	PF08353	DUF1727		Domain of unknown function (DUF1727)	Wuster A	anon	Pfam-B_2131 (release 18.0)	Family	This domain of unknown function is found at the C-terminus of bacterial proteins which include UDP-N-acetylmuramyl tripeptide synthase and the related Mur ligase.	25.00	25.00	29.30	28.40	22.00	18.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.45	0.71	-4.46	66	1470	2009-01-15 18:05:59	2005-08-11 10:01:48	5	4	1459	0	228	929	38	108.60	40	24.67	CHANGED	LlK..NPsGhspslshl........ssps......................................hslllhlN...sshADGpDsSWlWDsDFEpL.st.p.......lpplhsuG.RttDhAlRL+hA..Gls.............pphph..pp-hcpslpt..hppssscp..lYlL....sTYTAh	.....LsKNPsGhspuL.sh.lt......s.ts..............................................hsl...ll...hLN...uNh.....AD...GhD....sS.WIWDsDFEpl..sp.p.......ltp....lhs.uGs.R.tpDlAlRL+lA......Gls....................t....lh...tp-.lppslpp..hp..tps.spc.....shlL....uTYTAh.................	0	76	155	202
+8186	PF08354	DUF1729		Domain of unknown function (DUF1729)	Wuster A	anon	Pfam-B_3179 (release 18.0)	Family	This domain of unknown function is found in fatty acid synthase beta subunits together with the MaoC-like domain (Pfam:PF01575) and the Acyltransferase domain (Pfam:PF00698) [1].  The domain has been identified in fungi and bacteria.	25.00	25.00	40.10	39.20	20.80	19.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.77	0.72	-4.18	31	433	2009-01-15 18:05:59	2005-08-11 10:05:45	5	23	350	9	202	457	1	54.90	53	2.12	CHANGED	IPsLD-cFEhaFKKDSLWQSEDl-AVlspDspRVCILpGPVAspaos..pssEPlt-IL	..VPVlDc-hcpWa+pDSLWQSED.pth...DsspVCIl.GPsAVtthT..plDEPVu-lL......	0	48	111	168
+8187	PF08355	EF_assoc_1		EF hand associated	Wuster A	anon	Pfam-B_4111 (release 18.0)	Family	This region typically appears on the C-terminus of EF hands in GTP-binding proteins such as Arht/Rhot (may be involved in mitochondrial homeostasis and apoptosis[1]).  The EF hand associated region is found in yeast, vertebrates and plants.	19.10	19.10	19.40	19.60	18.20	18.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.49	0.72	-4.69	32	382	2009-01-15 18:05:59	2005-08-11 10:07:56	7	37	244	0	248	390	0	73.90	40	11.79	CHANGED	sW..pssa.sosspNp.tGhlTLpGaLuQWohsTaLDhppTLEYLuYLGass.....................................ssssAlpVTRtR+hcp+ptps	...............W..ssshsso.sssN-.tGal.TLpGaLuQWo.LoTaLDsppoLE.YLuYLGash..................................................................ttpt.s..pssAl..p..V.TRs++hDhc+tp.....................................................	1	68	122	190
+8188	PF08356	EF_assoc_2		EF hand associated	Wuster A	anon	Pfam-B_3018 (release 18.0)	Family	This region predominantly appears near EF-hands (Pfam:PF00036) in GTP-binding proteins. It is found in all three eukaryotic kingdoms.	21.50	21.50	21.70	22.00	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.97	0.72	-4.23	30	391	2009-01-15 18:05:59	2005-08-11 10:11:02	7	40	244	0	254	401	0	88.10	46	14.14	CHANGED	spPLsspsLtslKpslpcp.hPsuspp...pGlTlpGFLhLNplahE+GRHETTWsILRpFtYsDsLsLp-caLhPc..........hclPsssSsELSstGY	........................................pPLtspsLpclKp.llp+p...hs-G.Vtc...........sG.lTL..cGFLaLps..LFIp+GRHETTWslLR+FGYsDsLpLss-aLa.Ph..........lclP...s...ssosELs.puY.........................	0	71	126	194
+8189	PF08357	SEFIR		SEFIR domain	Fenech M	anon	Pfam-B_33671 (release 17.0)	Family	This family comprises IL17 receptors (IL17Rs, e.g. Swiss:Q60943) and SEF proteins (e.g. Swiss:Q8QHJ9). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (Pfam:PF01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways [1].	21.40	21.40	21.50	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.82	0.71	-4.15	15	480	2012-10-02 18:56:14	2005-08-11 10:17:46	6	21	166	0	243	474	10	138.00	22	25.54	CHANGED	hKValsYuu.DsshahchVtphAphLpshh..GhEVslDLW-chclsp.G.hpWhtpp....lppushVlllhS.sh.thhcppsscpcusspspup...........t-hFhsshstl...l.p..p..spshp+alsVYF.shspppclPshLph..sspapL.cphsplhscL	.......................................+VhlsYSt...Dss.a...phVhphAphLpsh....GhcVh....lDl..a-p.p.........lt..t.u..hpWhtpp.................lpp....ss..hllllso.s.......h..hh.ptt.t.t.p..p..ps.s.s..t.tps................................................tshah..h.t..ht.h............ph..p......stsh.t.+als..shF..t...sppt......p..l..P..shhp........h.ha..p..h...pph.phh.t.........................................................	0	52	85	148
+8190	PF08358	Flexi_CP_N		Carlavirus coat	Wuster A	anon	Pfam-B_2014 (release 18.0)	Family	This domain is found together with the viral coat protein domain (Pfam:PF00286) in coat/capsid proteins of Carlaviruses infecting plants.	19.70	19.70	24.90	24.60	19.10	16.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.48	0.72	-4.19	25	358	2009-01-15 18:05:59	2005-08-11 10:18:53	5	3	50	0	0	371	0	51.70	47	17.60	CHANGED	RLspLp-hLppppsusplsNsuFEh.GRPsLc.sssM+sDsoN.sYsRPSlDtL	..RLspLhEhhtpcppsssloNsuaEh.GRPsLpssssMRtsPsN.PYuR.SlDtL....	1	0	0	0
+8191	PF08359	TetR_C_4		YsiA-like protein, C-terminal region	Fenech M	anon	Pfam-B_20730 (release 17.0)	Family	The members of this family are thought to be TetR-type transcriptional regulators that bear particular similarity to YsiA (Swiss:P94548), a hypothetical protein expressed by B. subtilis.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.54	0.71	-4.22	8	631	2012-10-03 00:15:22	2005-08-11 10:46:25	6	4	485	2	267	630	83	130.10	20	62.86	CHANGED	FcEKMGpFVE+IccchsstsospEKLtlLlcpHFptLuuDhcLAIVTQLELRQSNpELRhKINEVLKGYLsllDcIltEGhcpGEF+p-LDlRLARQMIFGTlDEsVTsWVMs-pKYDLsALucsVacLLlpG	..................................................................................thlpphcp.th..t.t.....p....s.shp+.Lth...llc....sHh...ph...l....t..p...s...p....s....l.....s.....h.l.h.....h...E..h.+.p.t..s..p..c..l.p...p.c.l..p.p.lh...+...p.....Y....hphlp...cllpcGhppGphc....s.-...ls....s.c.lspphlhGslp.th.lhphhh..s..p..t..p.hs..h.t.sp..hhthh...h........................................	0	121	209	240
+8192	PF08360	TetR_C_5		QacR-like protein, C-terminal region	Fenech M	anon	Pfam-B_96140 (release 17.0)	Family	This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein (Swiss:P23217), a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA (Swiss:P23215), a multidrug efflux pump [1]. The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.51	0.71	-4.18	3	259	2012-10-03 00:15:22	2005-08-11 10:46:40	6	3	203	104	24	172	11	128.70	32	65.29	CHANGED	cppcWpEKWcccEKpYoTuTEKLYulAEasL.p-YppPLpNAIpEFuo-.ssosSIl-cMhuLsscslcsYcsIl-EGIQSGEFpI-NVcDlShIluuhLuGLssFhHEh-hcELc+LaNKAIsIFLpGlSs	................................................pW.-pWpcc....ph.h....pTspEKLYths-hhl..psl.p.pPlpp.....A.hpEF.p.hp..hhocp.l.-clht.lpc.c....hsha...cpLl-cGIpSGEFp....ps.sscslshIlsu.h.l.s.G.ls..s.h.ha...p.....s.h.c..chcc.lhpch.slhLpGhs............................................	0	11	19	20
+8193	PF08361	TetR_C_2		MAATS-type transcriptional repressor, C-terminal region	Fenech M	anon	Pfam-B_3020 (release 18.0)	Family	This family is named after the various transcriptional regulatory proteins that it contains, including MtrR (Swiss:Q6RV06), AcrR (Swiss:P34000), ArpR (Swiss:Q9KJC4), TtgR (Swiss:Q9AIU0) and SmeT (Swiss:Q8KLP4). These are members of the TetR family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [1,2,3].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.60	0.71	-4.20	12	1463	2012-10-03 00:15:22	2005-08-11 10:46:56	6	2	937	24	179	672	28	119.10	37	55.81	CHANGED	sPLpllRElLIalLpusVs-.+pRtlMEIlFHKCEFVGEMssl.phpcpLhhtsYsRIEpsLpcCIptt.LPssLch+RAAIhhRuhhoGlhENWLFsP-SFDLpp-AtsLVDshl-Mlph	..............................................................DPLphLREhLIhsLpthspp.RpptLhc.I.laHK.CEFs..sEMhsltptpcphshp..s.h.pplc....psLppChpt..thL.sssLsschAsIlh+uhlSGlhpNWL..hsP..p.....uaDLhKpA..shVshlLcMh......................................	0	27	74	128
+8194	PF08362	TetR_C_3		YcdC-like protein, C-terminal region	Fenech M	anon	Pfam-B_4012 (release 17.0)	Family	This family comprises proteins that belong to the TetR family of transcriptional regulators. They bear particular similarity to YcdC (Swiss:P75899), a putative HTH-containing protein. This family features the C-terminal region of these sequences, which does not include the helix-turn-helix.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.73	0.71	-4.47	16	1091	2012-10-03 00:15:22	2005-08-11 10:47:06	6	4	871	4	194	637	128	140.80	48	65.60	CHANGED	LcslL-sWLpshpsFcsps-PhpsLsuYI+sKlEhSR-hPpuS+lFAsEIhpGAPpl.s.LtppL+thscc+sslIptWlcpG+l.AslDPhHLlFsIWAsTQHYADFshQlpsVoG+sthscsta-pAscslppllLcGhtPc	.......................LcpIL-lWL.uPLc.s.F.c.t.-.hs.PltAlp.cYIRhKLElSRDaPpASRLFshEhltGAPhLhc..c..LsucL..Ks.L...l.-cK.u.A.lItuWlc....sG+.l.A.......P.lDPpHLIFhIWAsTQ.HYADFusQVcAVT.G...t.sh.t.s-shFsps.s-sVp+lIlcGlts...............................................	0	30	71	133
+8195	PF08363	GbpC		Glucan-binding protein C	Wuster A	anon	Pfam-B_3074 (release 18.0)	Family	This domain is found in the Streptococcus Glucan-binding protein C (GbpC) and also in surface protein antigen (Spa)-family proteins which show sequence similarity to GbpC [1].	21.00	21.00	22.60	26.10	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.72	0.70	-5.16	15	406	2009-01-15 18:05:59	2005-08-11 10:50:30	5	32	178	6	30	396	0	263.90	27	26.07	CHANGED	EpcKs-..DGaLo.cPpu.QuLVF-s.EPsAplolso...................thtpYsp+ph..phcshcl.pthpssstssushphhushssKtshop.hs.t........VlLc+GpslTsTYTNLpNSpYs....GKKISKlVYpYTlcsoop.ps...+lhlslasDPTlslFsuAaTGssc.+pssl.lcschpFYDEsGp.Ishss...ALlSluSLN+pps........uIEhsKsasGp..FlcIsGSSls.cpsGplYAscohsaKps..GS+ash........SsWDoss......uPsuWYGAGssph.oGsshphTlGupsss.s....................sIWFuhN	...........................................................................................................................................................................ctp..pu.ls.cs.u.psLsapp..EspA.h.s..hps.........................htph.tt.h..th..t...t.h.t.hpps.thht..s.p.th.h.sshsst.p.t................hh..lcpGpshosTYsNLps...upap.....G+K....IoKlh..apY.s.lpss.s.p...ps....ph..hhl.sDP.Thshhhu.......s.psps........p....th.hph.p.hp.Fa..DcsGp...lshsp.........ulhuhuSLNptts.......................phEhlp.s..h..s.sp......al.......IsGSoVsh.p.s.s.s...t......hYusps..phtps......Guphs............................ssWDs.ss.................................us.uaaGAushph.sssphsh....o.h.Gtpsts.s.....................shWFuhN..............................................................................	0	4	11	20
+8196	PF08364	IF2_assoc		Bacterial translation initiation factor IF-2 associated region	Wuster A	anon	Pfam-B_3037 (release 18.0)	Family	Most of the sequences in this alignment come from bacterial translation initiation factors (IF-2, also Pfam:PF04760), but the domain is also found in the eukaryotic translation initiation factor 4 gamma in yeast and in a hypothetical Euglenozoa protein of unknown function.	20.90	20.90	21.20	20.90	19.40	20.70	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.78	0.72	-3.94	89	1458	2009-01-15 18:05:59	2005-08-11 10:57:39	6	17	1446	0	330	951	291	40.90	51	4.66	CHANGED	stc+lTLp.........R+ppopl+pshupG.....+s....KsVsVEVR..KKRshl+ps	...........tPcKLTLp.........RKTpSTl.p.lsu..ouG.............KS...............K.oVQVEVR..KKRTaVKRs......	0	70	174	253
+8197	PF08365	IGF2_C		Insulin-like growth factor II E-peptide	Wuster A	anon	Pfam-B_4175 (release 18.0)	Family	This domain is found at the C-terminal domain of the insulin-like growth factor II (IGF-2, also see Pfam:PF00049) in vertebrates and seems to represent the E-peptide [1,2].	21.00	21.00	21.50	22.00	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.89	0.72	-4.21	8	168	2009-01-15 18:05:59	2005-08-11 11:00:23	6	3	122	0	22	173	0	53.80	62	28.71	CHANGED	Ka.KYDlWQ.KSuQRLRRGlPAlLRARRaRhhAcclcAtcpAp.hHRPLhoLPopcP	......Ka.+..Y-..sWp.puAQRLRRGlPAlLRA++hRp.AcclcAhcpAh.hHRPLIuLPoc.P..............	0	1	4	10
+8198	PF08366	LLGL		LLGL2	Wuster A	anon	Pfam-B_4088 (release 18.0)	Family	This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn [1].  It has been identified in eukaryotes and tends to be found together with WD repeats (Pfam:PF00400).	22.00	22.00	23.10	24.30	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.31	0.72	-4.14	12	358	2009-01-15 18:05:59	2005-08-11 11:10:57	8	12	89	0	195	366	1	104.40	45	9.98	CHANGED	PhpppsPaG........s.PCKuIpKl.a+ss.+supsFlIFSGGMPpsshGc+.pCloVhp.upspssL-hsppllDFhslsps..sschp-PhAlsVLLEc-LVllDLpssGaP	............................hpshhPa.G..........P.PCKsI.Kl....a..+os..c.s..up..sFlIFSG................Ghsh...ss.hGcR..slTVh+..G+stssL...-hsppllDFhTl.......s..........-s.s..h...............s..................s.-...........a......p-.....P......aAlVVLLEc-LVVlDLppsGaP........................	0	45	59	124
+8199	PF08367	M16C_assoc		Peptidase M16C associated	Wuster A	anon	Pfam-B_3062 (release 18.0)	Family	This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (Pfam:PF05193).	25.00	25.00	25.90	25.40	24.90	23.90	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.32	0.70	-5.53	22	854	2009-01-15 18:05:59	2005-08-11 11:13:51	6	17	730	10	360	815	243	242.30	23	25.25	CHANGED	hpPcpshppcpspcEppcLcphhppLoEp-pcpIhcpuhpLpphQpppp...sLs.sLPsLslsDlscpscphslpppp.sshplhh+shsTNsIsYhchhhsls.slPt-hhPalsLassslspl.GTtshsYpphtppIphpTGGluhusplhssspsspphp.thtlsupALscpsschFplhp-llspscFsctc....Rl+.LlpphtuphssulssSGHsaAhshusupho.sutlsEphuGls.lchlpcL	.............................htPctshtpcppptp....ppcLpph....pts.L......o......c......c......-......hpp..l..hc.ps.tp.L....pph..Qp..p.c.............sls...pL...P..t........Lp..lpD.l....s..p..p..h.....p.........h.h.............h...p.................p......p.......h...............s.........s.............h....s...............l........hh.p.ph....T..NGlsYh..phhh........s........l........s...s........l........s....p....-.....h...............sa...lsLhsp.hlsp..............l.G.Ttph.s.a.tc.l.....pphlphpT.G.............G.lsh.....s...hp.....h.............h......s....s.........h....p......s.........h........s......p.........h...............p...s...t..........hh......l........su+s....Ls...pphschhcl.h.p-ll..........pp..sc...F.s...-pc.......Rl.+pllpptps..ph.pss.lhsuGHthAhtp.usuth.o.sut.h......p-.thsGls.hphlppl...................................................................................................................	0	144	229	310
+8200	PF08368	FAST_2		FAST kinase-like protein, subdomain 2	Vella Briffa B, Fenech M	anon	Pfam-B_2858 (release 10.0)	Family	This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis [1]. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.	26.90	26.90	26.90	26.90	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.05	0.72	-3.61	22	367	2009-01-15 18:05:59	2005-08-11 11:15:47	7	6	76	0	185	347	0	87.50	27	13.55	CHANGED	phph+LhpLstslpLEsP-a......psPhL.s...p........hspcstphpsh.ppltcsLpplL.Guppth+hsVhTsasaslDhEshLDpc.tpsLP	......................................hhtpLhpLstslpLE....tPtY......pGPh.L.tt..p.......hhspps.tph...shpppltcsLppLL.Gupph....hptslhsPasa........s.l..DhElhlDpp.tpsLP...........	0	26	39	86
+8201	PF08369	PCP_red		Proto-chlorophyllide reductase 57 kD subunit	Wuster A	anon	Pfam-B_2047 (release 18.0)	Family	This domain is found in bacteria and plant chloroplast proteins. It often appears at the C-terminal of Nitrogenase component 1 type Oxidoreductases (Pfam:PF00148) and sometimes independently in bacterial proteins such as the Proto-chlorophyllide reductase 57 kD subunit of the Cyanobacterium Synechocystis.	27.30	27.30	27.90	27.60	26.30	27.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.22	0.72	-4.09	132	610	2009-01-15 18:05:59	2005-08-11 11:17:14	5	21	408	2	163	571	349	46.20	42	10.64	CHANGED	Wss-ApttLc+.l....Ph.FVR....t+lR+ssEphApppGhsplTh-hlhp.A+	........Wss-ActELpK.I....Ph.FVR....s+l++NTE+aARcpGhpplTlEshhsAK...	0	45	93	131
+8202	PF08370	PDR_assoc		Plant PDR ABC transporter associated	Wuster A	anon	Pfam-B_2126 (release 18.0)	Family	This domain is found on the C-terminus of ABC-2 type transporter domains (Pfam:PF01061).  It seems to be associated with the plant pleiotropic drug resistance (PDR) protein family of ABC transporters.  Like in yeast, plant PDR ABC transporters may also play a role in the transport of antifungal agents [1, also Pfam:PF06422].  The PDR family is characterised by a configuration in which the ABC domain is nearer the N-terminus of the protein than the transmembrane domain [1].	22.70	22.70	23.30	23.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.01	0.72	-4.46	38	427	2009-01-15 18:05:59	2005-08-11 11:20:17	6	26	40	0	289	452	0	64.60	40	4.80	CHANGED	Wsphhsss..s....pTLGtslLcuRGlas-shWYWIulGALlGFsllFNhlaoLALsaLpPhs+upullS	.............Wpp..sss...s....polGhtlLcuRGlFs-s..hWYWIGlGALlGaslLFNllFslALsaLs..Phscspshl.....................	0	35	197	250
+8204	PF08372	PRT_C		Plant phosphoribosyltransferase C-terminal	Wuster A	anon	Pfam-B_3195 (release 18.0)	Family	This domain is found at the C-terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins.  It contains putative transmembrane regions.  It often appears together with calcium-ion dependent C2 domains (Pfam:PF00168).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.87	0.71	-4.72	29	485	2012-10-01 21:10:52	2005-08-11 11:26:41	5	13	121	0	278	450	4	140.40	36	18.93	CHANGED	LPTlFLYhFhIGlWp..YRhRPRtPP.HMDs+LSpA-u..spPDELDEEFDoFP.To+ssDlVRhRYDRLRoVAGRlQoVVGDlATQGERlQALLSWR..DPRATulFlhhCLlsAlllYssPh........+llsllsGh....YhlRHP+FRs.+hPSsPhNFFRRLPupoDshL	..........................................................................................hs.s.-s..h.p..DElD.E..E.hD.shs..ss.c......chl+h..RYctlpsVuu+.lQsllG-lAo.GERlpslhsWp..sPchoslhllh..h.hlusll..LYhsPh..........+hl.sllhGl...........ahhp+......+hRs.....t.h...P...s.....l..sF..hpRlPucsp................................................	0	51	143	213
+8205	PF08373	RAP		RAP domain	Fenech M	anon	Pfam-B_5583 (release 17.0)	Domain	This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain [1]. The domain is involved in plant defence in response to bacterial infection [2,3].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.82	0.72	-4.18	79	594	2012-10-11 20:44:44	2005-08-11 11:27:25	5	25	110	0	425	598	10	58.80	25	8.24	CHANGED	lElsGspHa..............hpso.pphp......spsth+p+hLpthG.apl.lplsaa....................-Wpph...sppp+hp.Y..lpch	..............................h.s.ppF.......................................................................spss..pphh..............Gppsh+cRpL..........p.t.h.G..a...pl.lplsaa....................EWpph.....pspppphp.YL+p............................................	0	160	211	306
+8206	PF08374	Protocadherin		Protocadherin	Wuster A	anon	Pfam-B_4100 (release 18.0)	Family	The structure of protocadherins is similar to that of classic cadherins (Pfam:PF00028), but particularly on the cytoplasmic domains they also have some unique features.  They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localised mainly at cell-cell contact sites.  Their expression seems to be developmentally regulated [1].	25.20	25.20	25.50	25.20	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.57	0.70	-4.71	7	319	2009-01-15 18:05:59	2005-08-11 11:47:02	6	13	55	0	124	322	0	198.20	47	21.31	CHANGED	oluNuollps.lt+SlcTPLspsIussspst.u..pphlsIhlullAGshsVlLlIhlsshlR.CRpspp+puhQtGKp..sp-ahoP..........ptps+p....pKt..KKcKK...........pKSsKs.h.shVTlcts+s--tht-phshplsL..-hpppohu+a.....hPssapPs............SPDLARHYKSuSP.PuhQLpPpoPsA.sKKHpllQ-LP.sNTFVGus..................ucssSouSDpaSs.pCposs.pa	..........................oluNuohlpsLl.t+Shc.TPLs.sIu.sss.p.t.s..pphlsIhlulVAGshsVlllIhlssll.R.CR.....psp.php.....uhQtuKp..sp-ahoP..........p.csKp.........pKt...KKc..K.K...........pK...SPKs.h.shVTlEtsKs--tst-t.hshplsL....-h-ppohu+a.....hPssatPs............SPDLARHYK.SuSP.PuhQLpPpoPsu.sKKHpllQ-LP.sNTFVGu...................ucssSouSDpaSs.pspops.ta.....................	0	5	16	57
+8207	PF08375	Rpn3_C		Proteasome regulatory subunit C-terminal	Wuster A	anon	Pfam-B_4098 (release 18.0)	Family	This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function [1].  It occurs together with the PCI/PINT domain (Pfam:PF01399).	21.20	21.20	22.90	21.80	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.39	0.72	-3.57	24	366	2009-09-11 08:23:08	2005-08-11 11:49:06	6	6	295	0	240	357	3	65.90	51	13.11	CHANGED	DlYSTp-PppsFcpRIpFCLpLHN-uV+AMRYPssppcpp.cpt.pppp-c-p....-ltccls-s.-hD..D	......DlYuTpEPQhAFHpRIpFCLslHN-uVKA......MRaPsssapp...-..lcsA...c-pREREp..-..ElAKEhsEt..D.D.................................	0	84	136	202
+8208	PF08376	NIT		Nitrate and nitrite sensing	Wuster A	anon	Pfam-B_37103 (release 17.0)	Family	The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations.  The NIT domain is predicted to be all alpha-helical in structure [1].	20.40	20.40	20.50	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.53	0.70	-4.85	118	931	2009-01-15 18:05:59	2005-08-11 12:01:15	5	47	468	2	424	987	49	239.30	17	31.40	CHANGED	husLlHpLQcER...........GhSusal....uSp......G.t...th....sspLtspRptoDpthsphpsthp........ph.ts.stt...........htpplsphhptLsp.LsslRppl.....Dshs.lsssps.hshYo.pllstlLsllsplsptsscsplspthsAhhshhpuKEtAGpERAllussaus.....sph.ssshhpchhshlupQpshh.cpFtsh..ussptpphapphhss...sshpp...lpphRphshs...........pss........tts.hs.hsupp.WFsts.Tp+I.....shl+pl.Esplss..plhpts	........................................................................h.spllptLQpER.............................sho.ssaL.............uus.......s...p..th........tsplppp+.tpoDpshsphppthp...........ph.tt.st............htptlsphhp.t.lsp.LsslRpp..l........................ss..tp...hs....s......sp.s....h.sh.Yo.pll..pt...l.......l.sh.h.t.......p.hs.....p....t...s......s...s.spl...sp...th...t.....u...h...h.......s.....l.......h.....p.....u+EhsutpRu.lhsss.hst..............................sp.h...sss...t....hpp......h.h....shhspp......p.....t....h.......h..pp.htsh..............us..s..p.t.....pphhpp.hhss.......sshpp......hpp...h.pp...th..hs...................................pss............tts..ht.....hs.s....pp...Whsh....totpl....sh....hppl.cpplhtph....h....................................................................................................................	1	142	295	380
+8209	PF08377	MAP2_projctn		MAP2/Tau projection domain	Wuster A	anon	Pfam-B_26981 (release 17.0)	Family	This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs.  All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (Pfam:PF00418), and a N-terminal projection domain of varying size.  This domain has a net negative charge and exerts a long-range repulsive force.  This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport [1,2].	18.20	18.20	18.30	18.30	15.50	18.10	hmmbuild  -o /dev/null HMM SEED	1134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.07	0.70	-14.11	0.70	-7.01	5	79	2009-01-15 18:05:59	2005-08-11 12:08:39	5	7	38	0	30	63	0	731.30	53	59.19	CHANGED	DKVADVPVSEATTVLGDVHSPAVEGFVGENISGEEKGTTDQE...KKETSTPSVQEPTLTETEPQTKLEETSKVSIEETVAKEEESLKLKDDKAGVIQTSTEHSFSKEDQKGQEQTIEALKQDSFPISLEQAVTDAAMATKTLEKVTSEPEAVSEKREIQGLFEEDIADKSKLEGAGSATVAEVEMPFYEDKSGMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSPKNQQDEKEL.LAKASQPSPPAHEAGYSTLAQSYTSDHPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKIPCFPIESKEEEDKTEQAKVTGGQTTQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEAVVAESSTGLPPVADDSQP.VKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDSKEHAKESEEVGDKVELFGLGVTYEQTSAKELITTKETAPERAEKGLSSVPEVAEVETTTKADQGLDVAAKKDDQSPLDIKVSDFGQMASGMSVDAGKTIELKFEVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADSSIDEKAEVQMEFIQLPKEESTETPDIPAIPSDVTQPQPEAlVSEPAEVRGEEEEIEAEGEYDKLLFRSDTLQITDLLVPGSREEFVETCPGEHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQPEEERRPYPHD.EELEVLMAAEAQAEPKDGSPDAPATPEKEEVPFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTEQLETIPKEERAEKEARRPSLEKHRKEKPFKTGRGRISTPERK.VAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLILKPAIKYTRPTHLSCVKRK	..........................................................................................................................................................................................................................................................................................................................t....t.......t...t......p.......p.p.h...s.tchph.h..t...D+SGMStYFETSsLK--h..sc..s..t...uSDYYELSss+t...-..sh...t.....p.tp.pt.............sh.EhuYSTLspsh..............st-ph.TlsPplht-Kp-..hhsKNKDD..LpLSRSLGLGGRSAIEQRSMSINLPhSCLDSluLGhshGRu+sLSPLAoDILopTSGShDEusD.YLPsTTPul-KhPsFP...h-stt.......t..............+.....s.t..p......p...sESP..ApphYKNGsVhuPDLPEMLDLsGoRSRLuS.ss-sEhsp+KSs.u-....h.-sts.t.hs.hssps...h.Ks-uQhE-hGYCVFscYosPhPSPsps......t...........................................................................................................................................................................................................................................................................E.s..+-..+..E.EhKEKs.sKPDLVHQEA...hDtE-sYp.oGtt....c..................t.....t...c.......c...p...p..........p...........p....p...t........pc....................h...h.t.......t.................t.....t........p.......t.p....c..h.t-...........s...-...................E.+uslESVVTlEDDFITVVQT.hD-uE.uuHSVRFus..p.-..ph..........t..cE.p.....-sp.Es......p-.sP...-sPAsPp+E.Els.SEhhTEoYDDYKDETTIDDSIMDsDSLWVDTQDDDRSIhTEQLETlPKEE+.A.......-K-.......sR....RsSL-KH.RKEKPh.Ko...G...R..GRI..STPERK.lAKKEPST.V.SRDEVRRKK..AVhKKAELuKKoElQuHSPSRKhILKPAlKaTRPT.HhSCVKRK................................................................	1	2	5	15
+8210	PF08378	NERD		Nuclease-related domain	Wuster A	anon	Pfam-B_9750 (release 17.0)	Family	The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins.  It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-11.32	0.71	-3.82	377	1767	2012-10-11 20:44:44	2005-08-11 14:40:20	6	64	1278	0	464	1715	271	125.70	17	30.27	CHANGED	pGttuEpts..t....phL.....pt.h.pp....h.h.h......ts.h.h.......................tt..pspIDhlllss.tt..lhllEsK....s.............hp.G......h....t..........h.....................................thts...Plpp.s....ppphptl....pph...l........................................h......hpslllhs	................................................uE..h.h.phL............pt.l.ppt...hhl.h.......ps.lhl...............ttspttpIDalllst..pG..lhllEsK......s.........................hp..G....p..lh....ss........tp..s....h.................................................h...t............................h.phts.......PlpQ..s..........tpphphl.....tph....l...........................................................h................................................................................................	0	152	325	415
+8211	PF08379	Bact_transglu_N		Bacterial transglutaminase-like N-terminal region	Fenech M	anon	Pfam-B_2190 (release 18.0)	Family	This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (Pfam:PF01841).	21.50	21.50	21.60	21.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.48	0.72	-3.67	188	1621	2009-01-15 18:05:59	2005-08-12 17:21:43	5	8	789	0	617	1553	423	80.90	28	16.48	CHANGED	phplpHpTpYpYspPVshuhpplRLpP..pssst.........Qp.llsaplplsPtstphpp.hpDhaGNtlphh.sh.ppspp.c.lp...lpspupV-h	..............................hplpHpTpYpYsps.Vphu.phlRLpP.tspsp.........Qp.llsaplplp.......Pts....t...........hhst.tpDsaGNhlsthsh.spspp..p.Lp...lpspuhV-...............	0	164	370	493
+8213	PF08381	BRX	DZC;	Transcription factor regulating root and shoot growth via Pin3	Fenech M, Coggill P	anon	Pfam-B_2116 (release 18.0)	Domain	The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2]. BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway.  BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot [3]. The family features a short region of alpha-helix, approximately 60 residues in length, which is found repeated up to three times [1]. BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action [4].	24.50	24.50	24.70	26.80	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.98	0.72	-4.91	34	367	2009-01-15 18:05:59	2005-08-15 09:27:43	6	31	36	0	237	374	0	56.60	49	10.58	CHANGED	ssptEWl-QhEPGVYlThsshssG.sptLKRVRFSRcpFs.cppAcpWWpENps+lhcpYs	.....t..ppEWlEQsEPGVYITls..sLs.s......G.sp-LKRVRFS.....RcpFs.chpAcpWWtENps+lhcpYs......	0	32	143	192
+8215	PF08383	Maf_N		Maf N-terminal region	Fenech M	anon	Pfam-B_3103 (release 18.0)	Family	This region is found in various leucine zipper transcription factors of the Maf family. These are implicated in the regulation of insulin gene expression [1], in erythroid differentiation [2], and in differentiation of the neuroretina [3].	20.20	20.20	20.30	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.60	0.72	-4.40	9	171	2009-09-11 10:53:55	2005-08-15 09:39:28	6	2	45	0	78	126	0	34.90	59	11.59	CHANGED	spLE-LYWM..us..h.QQhs.PEuLsLTPEDAVEALIGs	...spLEDLYWM..uu...h.QQlN.PEALsLoPEDAVEALIut.......	0	5	16	35
+8216	PF08384	NPP		Pro-opiomelanocortin, N-terminal region	Fenech M	anon	Pfam-B_1053 (release 18.0)	Family	This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity [1].	20.50	20.50	20.50	20.60	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.54	0.72	-4.33	20	577	2009-01-15 18:05:59	2005-08-15 09:51:58	5	4	358	0	22	546	0	23.50	84	11.75	CHANGED	QCWE.so+C+DLsoEsslLECIcsC+sDLoAEoPlaPGNGHhQPho	................................SAESPVFPGNGHMQPLS..........	0	1	3	8
+8217	PF08385	DHC_N1		Dynein heavy chain, N-terminal region 1	Fenech M	anon	Pfam-B_3094 (release 18.0)	Family	Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit [1]. The region featured in this family includes the sequences implicated in mediating these interactions [2]. It is thought to be flexible and not to adopt a rigid conformation [1].	22.20	22.20	22.40	22.20	21.60	22.10	hmmbuild  -o /dev/null HMM SEED	579	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.78	0.70	-6.14	40	1478	2009-01-15 18:05:59	2005-08-15 10:01:37	7	120	275	0	1051	1462	56	440.20	18	14.51	CHANGED	DsshlppLpssVspWh+pIpplhphsps.st......sostsElpFWpshppsLppItpQLpu.cVphslclLcpu..Kp.phhssFps.t.slccuhscspchsphlcsh..hs-hL.tss....s..hsplppslsslhpplphhaphop..hs.pRhhsLlptIssplhpphpphL....ssp....p.lhp.h....-hs-hpphlps.shplhptaccpacchpshlcp.....tpccs.....ppaphp..tlhs+.hsphppRlppltphppsppph.pplhpt..................s.pst.hspslp...phtc.....-hppsacshpsls..sLDhssp...papsshppapp+hpclEpplsshlpct.h.sss.csspphF+llspFpsLh.hRPp.......Ipsslp.-htspLlcphcp-lcplpphFppph....p.tttphshh+shPs....luGsIhWs+pLpc+Lpph.hcplc...slh..s.....h.pps-.GpclppchsphpppLsp..pphappWhp...plppps..hslstsll..........pstsphcLh.VNF-spllpLh+El+hLthl..................s.........h..plPtshtplhpptcplhshtssLpchlcsasplhp.pl..pp.....hpt......Lltsphpclpphl.ptGls.lsWpsht..lptahp	........................................................................................................................hh..hpt.h..W.ptlpt...hht..p.t...........................s.s.tE.hpaW...th..............tth..l.pph.pt.t.h.hh...ht.hLp................pp................hh..........h..t........t.l.tth.pspp....hhtsh......p.l...t.....................p......p..h..p..h..l..lhphlph.hht.......sp........s....pRh....h...Lhpt......l...s...p.hhp.....hh...thl............s.t......p.lhp..............................ht.....h..phht...shphhp.app..h......th.pt..h..........t.t...............................t.a..ph.......hl..p.hp.h.pRht.p.l.....p..hhp....h.ph...th.....................................................................................................t....th........th.t..................php.t.h.h..p..h.p..p.h....p..............hc.ptt.............ta.p.t....shtt.....app.ph......tt....l-tplts......hhp.........pt.h.tph...t.sh..pp...................hh...ph...h...t.h..a..tt...lh........c.h.................lttt.....h..th...l..ht.h.tp-lpt.h.pp..........app...ph.......................tt......h...ps.........hP..........huut.lhWsppl.p+........l.pt..hphhp...........th.................................h.p....p...s........pth.......hpp....hpp.......h.......ht.lt.p.............t..haptWhp..........php....p.........................t...h....p....t..lh..........................................t.tthtl.............lNas.plhtlh.cEsc.h..h...............................................................t.........h..plP..h.phh.t..ptp..p..hh....h...tL..........hh.p.ap..phhp..th...............................Lh....t..htthp.th.l.....t.............u...h.........ltWps...........t...........................................................	0	416	544	845
+8218	PF08386	Abhydrolase_4		TAP-like protein	Fenech M	anon	Pfam-B_3096 (release 18.0)	Family	This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans (Swiss:Q54410). A member of this family (Swiss:Q6E3K7) is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterised from Propionibacterium freudenreichii [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.41	0.72	-4.13	38	1197	2012-10-03 11:45:05	2005-08-15 11:43:12	5	9	575	0	480	3862	878	102.40	26	19.93	CHANGED	sPh..aGshhstshh..CssW............Ps..ssstshsphs.s...s...s.sslLllssptDPsTPapsApchsctLss..u....tllohpGt.GHsshh.ssspClsptlssYLhsGphPt.....tsssC	............................................................huthhu.s.h...Ct..h..W..............................Ps...tss..t...h.t...ht..s.....ts............s..sPlLllus.p.tDPsT...Ph.p......s.A.p.p.h.upp..h.ss....u........hl.l...o..hcGs...G...Hsu...h.........h...ts...........s......t...C...s.....s.ps......l.ssY.L.h.s.G.phPt......tshhC....................................	0	153	319	425
+8219	PF08387	FBD		FBD	Fenech M	anon	Pfam-B_1153 (release 18.0)	Family	This region is found in F-box (Pfam:PF00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes [1]. In fact, several family members are annotated as being similar to transcription factors.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.48	0.72	-4.50	129	806	2009-01-15 18:05:59	2005-08-15 11:49:10	5	32	19	0	451	833	0	49.30	25	12.21	CHANGED	ta...p..sslPcCLhopLchlph.p...........tapuppp.c.hcls.pYlLcNuphL.Kchslph	................................................s.cCl.spL.cplph.p............sapGpps..-..lphs..pallpNupsL.cphsl.............	0	116	212	319
+8220	PF08388	GIIM		Group II intron, maturase-specific domain	Fenech M	anon	Pfam-B_4063 (release 18.0)	Family	This region is found mainly in various bacterial and archaeal species, but a few members of this family are expressed by fungal and chlamydomonal species. It has been implicated in the binding of intron RNA during reverse transcription and splicing [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.88	0.72	-4.19	164	2393	2012-10-02 14:46:49	2005-08-15 11:52:43	6	14	1025	0	536	2190	222	80.40	24	19.71	CHANGED	l+phpp+l.+p.lh.+ptps.......hshpplIppLNPllRGWssYaphs.sspph..applDphlhp+LhpWth++ap..p.......ht...........pphhhp+.....ha	...............................pphpp+l...+p...lh....+.ptt.s...........hshpphlc....p.LN.hl+GWhsYaph..s...ss....pph...hpplD.phlhp+Ltthhh+ca+...p.......ht...........hh.........hh..........................................	0	205	383	464
+8221	PF08389	Xpo1		Exportin 1-like protein	Fenech M	anon	Pfam-B_4058 (release 18.0)	Family	The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1, Swiss:P14068). This region is found just C-terminal to an importin-beta N-terminal domain (Pfam:PF03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus [1,2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.74	0.71	-4.29	59	1456	2012-10-11 20:01:01	2005-08-15 12:46:41	7	30	320	21	1051	1452	11	147.50	19	14.93	CHANGED	pphlhsc..Lshslsplhhp.a....sppWps..hls-ll...shhps.s...............shsthhlplLphLsEElh-....htp..sphspp+.ppcl+ctlpsp......hpplhphhhplLpp.ts..................splhptsLcslssalp.....Wlslshlh.....s.s...llshl.hphL......s.sph..........ppsAhcCL	.........................................................t..hlhs+Lshsls.p.lhhppa......spp.Ws.s..hls-ll.........ph..hps..s................................................ststhhltlLphLsEElhs...................htp....tphspp+..pppl+.....p....t.....lppp.........hppl..h....phhh.....p.llppttp................................................splhptsLc.sltpalp........alslshl..h.................p..st........ll.p.hl.hp.hl..........p....h...........ht.shcs......................................................................................	0	370	587	863
+8222	PF08390	TRAM1		TRAM1-like protein	Fenech M	anon	Pfam-B_3108 (release 18.0)	Family	This family comprises sequences that are similar to human TRAM1 (Swiss:Q15629). This is a transmembrane protein of the endoplasmic reticulum, thought to be involved in the membrane transfer of secretory proteins [1]. The region featured in this family is found N-terminal to the longevity-assurance protein region (Pfam:PF03798).	25.00	25.00	25.00	25.00	22.70	24.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.04	0.72	-4.47	61	512	2009-01-15 18:05:59	2005-08-15 12:53:12	6	5	230	0	347	489	0	65.70	30	16.18	CHANGED	hsphFltlsYph................sssshYspGhcDhsaVhFYhlhhohlRthlhcallcPlu.+thslppp+p	...................................................hthFlhlpYpl...............................................sssshYst.GhcDlshVhFYhllhshlRshlh-alLcPlu.+phtlppp+..............	0	80	162	266
+8223	PF08391	Ly49		Ly49-like protein, N-terminal region	Fenech M	anon	Pfam-B_1187 (release 18.0)	Family	The sequences making up this family are annotated as, or are similar to, Ly49 receptors (e.g. Swiss:P20937). These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function [1]. They are members of the C-type lectin receptor superfamily [2], and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (Pfam:PF00059).	30.00	30.00	30.50	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.67	0.71	-3.97	27	249	2009-01-15 18:05:59	2005-08-15 12:57:01	5	4	35	18	46	271	0	113.20	44	46.66	CHANGED	SVPWpLIVlsLGILChLLLVoVAVLsTpIFQYtQEKHph.pEsL.NhppphssMQsD.pLKEEhLpNKolECs.hps.......hL-sLpREQpRhapKTKohhsS.QcT.............G+tsEh+WFCaGlKCYYF	..........SVPWpLIVlsLGILChL.LLVhVsVLssp.IFQhtQ.cK+p.h..pEhL.Npppphs.....h.MQsDhpLK....EE.h..LpNKSlEsp.hpp.......hL-Sl.p+.-..QpRh.....apc..s+slh....c...o.pcT..............G+hs...c..aW.CaGhpCYYF.........................................................................	0	1	2	4
+8224	PF08392	FAE1_CUT1_RppA		FAE1/Type III polyketide synthase-like protein	Fenech M	anon	Pfam-B_1177 (release 18.0)	Family	The members of this family are described as 3-ketoacyl-CoA synthases, type III polyketide synthases, fatty acid elongases and fatty acid condensing enzymes, and are found in both prokaryotic and eukaryotic (mainly plant) species. The region featured in this family contains the active site residues, as well as motifs involved in substrate binding [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.77	0.70	-5.34	37	707	2012-10-02 12:25:54	2005-08-15 13:22:38	7	11	136	0	353	4319	396	250.90	42	57.47	CHANGED	ahhpRPR.s...VYLlDauCY+Psccp+lohpthhchsctssph.spcs.........lcF.p+llpRSGLG--TYlPculhphPsp..s..ohtpARpEuEtVhFuAlDcLFt+T......s.lpPc.-IGlLVVNCSlFsPTPSLSuMlVN+YKhRuslpSaNLuGMGCSAGlIulDLA+sLLp.sp..NoaALVVSTEslo.NWYhGscRSMLlsNCLFRhGGAAlLLSN..+st-+c.RuKYcLhHsVRTHpGADDcuapClhQcED-pGphGVuLS..K-LhsVAGcALKsNIsTLGPLVLPhSEpLhFhss.llt+Kl	..................................................................................................................hpRs+..s....lYLlDauCacPs.sp.h.....+........sshtthhch..p.h....t.......ph.....stps.....................lcF.p...+...ll...p...+SG.....l.......G.-.....c.........T...a.....h........P.......u...l.h...t.....h......P.sp................sh.t..t...u.........R........p........E..s..-....Vh....a........u.u.l...-.p....L.h.t+.T........s...lp.......P........c..-ls.l.L.l.V.N......s..S........h...F..s.P...T...P....S.Lo..uM.l...lN...+.Y.+h.R.s.s....l.t..o.a.NLuGM....GCSAGlI..ulD.LA+sl.L....p....sp.......s..s......hAlV....VSTEs..l.....o.............s...a.....Y.....h.....G....s.....p.....R.....u.......M.....L.....l.sNC.LFRh....G.G.A..Al.LL.S..N..........+........t.........t......t....t...+.............u.K..Y.....c.Lh...+..sV.RTHp..G..As..DcuapClhQcE.....D....p....p......G...p.hGlsL..S..K.-Lht.lAGc.AL+sNI.ss.LG..PlVLPhSEplhFhhs.hlh++.............................................................................................................	0	72	218	296
+8225	PF08393	DHC_N2		Dynein heavy chain, N-terminal region 2	Fenech M	anon	Pfam-B_3094 (release 18.0)	Family	Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (Pfam:PF08385) in many members of this family. No functions seem to have been attributed specifically to this region.	23.50	23.50	24.00	23.50	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.40	0.70	-5.96	94	2363	2009-01-15 18:05:59	2005-08-15 13:39:22	8	259	303	14	1713	2264	96	354.20	26	10.66	CHANGED	ppLpplpp-lpshpplWphhpphpp.phppatp.tsa.ppl...sspplcpplp...p.hhcphpplscph...pp...........hplhpplpp....plcpapphlPllps.L.+stuh........+...p.....R...HW.pplhp.hls.......sh.......t...ps..hoLpplls.hsl.h..patcplpcIsspAppEhslEptLpclcspWps......hpFphhsacs....p.....shllps..h--lhphL--phsplpohpsS........ahp....Fcpc.sppWcpcLshlpcll-hWhplQ+pWhYLEsIFsu..p..DIpppLPpEspcFppl-ppap.plhpps.ppsspllcss.t...sp.hhppLpphtcpL-plQKuLscYLEpKRptFPRFYFlSs--LL-IL..upup-Pp.tlQpHlpK.hF-uIsplphpppspp.......lhuhhSsE.G.Eplthtp.slphps......pVE..p...WLppl-ppM+poL+phlppulpphp	..............................................................................................................................................h.th.pphp.hpplaph.h..ph.p.th.pt.....hhp.t.a..p..l..........p.p..th...p...tpht........p..h..........p.....p.....h...t...p...h......c.th...pp.......................................hth.h.t...lpp..........pl....cph...h..p...hs..lltt..lps.uh...............+..p....................R..HW.ppl.p.h.ht...........hph.....p..................................ps...h...s.L...tplhp....hsl...h.........ph..tpp....l.pplstt.A.tp...Eh.s.lE....p.t..L.p.p..........htttWps..............................hph.ph....app......................p...........thhl..l.ps.....h-..-.l..hthl--p..htlps.hhsS........a.ht......F.ppp.lppWpp...pLsh......hppl.l....c.WhplQppW.......hYL...EsIF.u..........t...DI..t....pQ....LPp.E.....up.+F.pp..l-...pp.......ap..plM..........p...............ps........ps......s......p.....l.....l............ps............s.........t.........h................................s..hh...............p..........pLp....p.....htp........L...phhpK..u.LspYLE......pK...Rhh.....FP....R....Fa..........F.lSs...s-L..L-IL................u.p..s.p........s.st.....tlQ....Hl.pK.hF-s..ltplphpp.s.p................................hhuhh...S....t...E..G....Eh....l....h.....tp.............l.hps................pV.E..t........WLtpl.........tptMptol+phhtpuh.t..t.....................................................................................................................	0	747	940	1412
+8226	PF08394	Arc_trans_TRASH		Archaeal TRASH domain	Fenech M, [1]	anon	Pfam-B_18882 (release 17.0)	Family	This region is found in the C-terminus of a number of archaeal transcriptional regulators. It is thought to function as a metal-sensing regulatory module [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.04	0.72	-3.79	8	65	2012-10-03 05:12:49	2005-08-15 13:58:30	5	6	57	0	34	119	16	36.70	39	22.76	CHANGED	CDYCGpEIpG-PIshKh+N+lYYsCCsTCpcchKK+h	...........CDaCGppI..t..s..c..P..l..s.hK..h..ss.+s.YahCCsoChpph+cp......	0	8	15	27
+8227	PF08395	7tm_7		7tm Chemosensory receptor	Robertson H, Finn R, Fenech M	anon	Robertson H	Family	This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [1,2].	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.36	0.70	-5.44	78	1580	2012-10-01 21:54:26	2005-08-15 14:17:53	7	10	51	0	884	2288	0	315.20	12	89.70	CHANGED	lchhhhhspl.hG..lhsh........phstpptphph.hphhhhhhhhhhhhhhhhhhhhh...h.hhhthhhhptsthhphhhhlhhhlthlshhhhhltthhppppltplhppl....hplppphtptspttt..........phhshhhhhhhhhhhhhhhhshh.............hhhtthhhhshhhlhhhhhhh....hh.hhhhhahhhlhhlh..phhphlpppLpphhppht.......................hpppshtp...............l..pplhphappl.hplspplsphas....h.ll..hhhhhhh.lthshhha..hhhtphh.............p.hhhhhhhl......ahhh.hhhhh......hhhhssstspp....pspcssthl..tph..........htttspphppp..lcpFhlphh.ppph....phsssGhFslspshlhshhuulhoYlllLlQFchtt	..................................................................................................................................................................................h.........h.s......................................h........h.h....hhh..hh..h..h.h...hhhhh..h..hhhh..............................................t....h.....p.....hh...h..........h..............h.h...h...........h...h.h...h.h..h.hh.h.......hh......p.......t..p...p..hh.....ph....h...pp.h...............hphptp.....h...th.th.....................thh.h.hh.....h.h...h.hh.h....h.h.hhh.hhhhh...........................................h..h......h...hh...h...h...hhh..h..hh..hh.......................h.hh......h.......h.h.h....h.h.......h....h.h..lh.............th...ht...hl..pptl...pt.hht....p.........................................tp.p..t.....................................................l....pphhphat.p....l...hp.h.s.p.p....hsp...has....h.hl...hhhhhth...hthh.h.ha......hhhhthh................................hh.h.hhhhh.........................h.hh.h.h.h..hh.......hhhhhs..pt..h.p............................phppht.hh..........hph........................s..tp.h..ppt.........lp....h.....h...th......pp..........thphhs..hh.ls.phhh..thhsshhsahlhhhQh.................................................................	0	345	411	732
+8228	PF08396	Toxin_34		Spider toxin omega agatoxin/Tx1 family	Bateman A	anon	Mondal S, Ramakumar S	Family	The Tx1 family lethal spider neurotoxin induces excitatory  symptoms in mice [1].	21.10	21.10	24.80	24.70	17.80	17.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.82	0.72	-3.43	7	30	2009-01-15 18:05:59	2005-08-15 16:18:18	5	1	8	0	0	34	0	51.30	46	76.95	CHANGED	CIclGs-CDG..cKsDCQCCRcNuYCSC..h...FG.hKsGCKCpVGssuphhulC.+cKppC.sp.....ssspCppsshs+Rp	....ClphGpsCDG..cKsDCQCCtcNuaCSC..h...as.hchs..CpC.ht...................................................	0	0	0	0
+8229	PF08397	IMD		IRSp53/MIM homology domain	Wuster A	anon	Pfam-B_4120 (release 18.0)	Family	The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent [1].	20.50	20.50	20.60	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.32	0.70	-5.03	8	584	2012-10-03 12:17:00	2005-08-17 11:36:12	6	17	112	9	305	490	0	190.70	31	31.80	CHANGED	Y+sIMpQFN...PuLcNhlshGpsYc+ulpuhlhAucuYaDAlpKlGEhAssSps.S+ELGslLhcMu.sHRplpscLEchhpsFHcpLIspLEcKs-.DpKahssshK+YppEaKp+pcsL-KspSDLhKLc+Kupt...G+sst+hpl+Es..l-slsc+psplpcalucus+cALlEE+RRFCFLV-Kppslupp.huaaucuhshLpspL.sWpptsuDso+lP	................................hp....P.hcphlthupph.ptl....................pshs.Ast..s.......ah-.......Ah.....tK...........lu...-h...A..t...p................op.s..o...+...-..l.......G....ssLhphs.hHR..plpspLcph...h...p..shhppLls.Lp..cphE..t+...h.hs...t....hpKc.a...tp......Ea+pt..tpp.lcKppu.-.hh......KL......p+Kspt....................u+..ss...p......p..hcph.........lp.s....lssc.htl.p..p.h.ppuh...+pALlEERpRaChhlphhpsls................pp.hshhsc.hp...h....Lp..thh..hpthst-spclP.............................................	2	68	101	199
+8230	PF08398	Parvo_coat_N		Parvovirus coat protein VP1	Wuster A	anon	Pfam-B_2198 (release 18.0)	Family	This is the N-terminal region of the Parvovirus VP1 coat protein. Also see Parvovirus coat protein VP2 (Pfam:PF00740).	26.60	26.60	26.60	26.70	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.17	0.72	-4.18	11	1185	2009-01-15 18:05:59	2005-08-17 11:58:51	5	6	140	0	2	856	0	57.20	59	11.36	CHANGED	LPGY+YLGPGNuLDpGcPVNtuDuAA+cHDhuYsp.LKsGcNPYlpaNpADpcFlccLccDTSF	.......LPGhpYlGPGNt....L....ps....G.P.P.psssDuAA+hHDhpYuphhK.G.NPYh.hashADpch.cplppt.s...............................	0	1	1	2
+8231	PF08399	VWA_N		VWA N-terminal	Wuster A	anon	Pfam-B_2075 (release 18.0)	Family	This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, Pfam:PF00092) and Cache (Pfam:PF02743) domains.  It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits [1].	20.70	20.70	20.90	20.80	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.56	0.71	-3.50	11	476	2009-01-15 18:05:59	2005-08-17 12:04:57	6	21	88	0	252	411	0	113.30	37	11.56	CHANGED	AEps..ptpHpaptslt.pphpYYsA+hhs-hsc...........-sstsEhu.....hph.hpccspFpN.sVNhohSuVplPTslYpcsstlLNslpWocuL-sVFhcNhccDPoLpWQYFGSuTGhhRhYPAspW	.....................................................................Acphp...taph.p.sh......htYasuhh.sch.sp...............t.s.s.-ht.........hch.ht..sspFps..Vsh.shS.s.VplPTslY.pt.ss.llNslpWo..cuLs..pVFhc.....N...hcpD.PoLhWQYFGSuoGhhRhYPu.htW............	1	68	89	164
+8232	PF08400	phage_tail_N		Prophage tail fibre N-terminal	Wuster A	anon	Pfam-B_3101 (release 18.0)	Family	This domain is found at the N-terminus of prophage tail fibre proteins.	26.60	26.60	26.60	27.00	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.58	0.71	-4.45	9	1004	2012-10-02 19:08:27	2005-08-17 14:13:30	5	47	343	0	14	1041	4	125.20	65	25.71	CHANGED	MoVpISGlLKDGsGcPVssssIpL+Ap+sSsTVlssTVAos.s-psGpYuhclE.GpYsVhLts-GhsssasGsIsVhsDSpPGTLNsFL.tAhsEsDlpPEllpcFEthstpsscsAusuttssppAspsutsA	......MuVpISGVLKDGsGKPVpNCTIpLKA+RsSoTVV.....VNTVASENPD.EAGRYSMDVEaGQYSVhLLVEGF.P.PSHAGTITVYEDSpPGTLNDFL.GAMoEDDlRPEALRRFEhMVEEsARpAptAppNAupAcpSupsA....................	1	1	2	7
+8233	PF08401	DUF1738		Domain of unknown function (DUF1738)	Fenech M	anon	Pfam-B_3014 (release 18.0)	Family	This region is found in a number of bacterial hypothetical proteins. Some members are annotated as being similar to replication primases, and in fact this region is often found together with the Toprim domain (Pfam:PF01751).	20.60	20.60	20.60	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.68	0.71	-4.40	112	907	2009-01-15 18:05:59	2005-08-17 16:38:04	6	25	579	0	235	850	162	122.50	28	26.43	CHANGED	+tclY.pclTc....cIIspLEp.G.stPWhpPWp.....tsssshshPhN.toGcsYpGlNllhLWhss.tpGas.....sspWhTa+QAppLG...........upVRKG.E+uosl...laacp..hppc.....pp.t........ps.ptptcpl..shl+tasVF	..................................p..shhpplss.......plI.ttlEp.....G.shPWh+PWp.......tsthshPhN.ho...GctYpG.lNslh...Lh.h.ts..tpGas.........sspWhT.a+Q.Ap.p.h....G....................................................u..pV+..KG..E..+us.sl...laaph......hpcp............t.p.t...................tptptphpth....shh+tapVF.............................................................................	0	46	136	189
+8234	PF08402	TOBE_2		TOBE domain	Bateman A	anon	Pfam-B_4178 (release 18.0)	Family	The TOBE domain [1] (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulphate (Swiss:P16676). Found in ABC transporters immediately after the ATPase domain. In this family a strong RPE motif is found at the presumed N-terminus of the domain.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.46	0.72	-3.98	128	14426	2012-10-03 20:18:03	2005-08-18 14:22:02	5	12	3742	54	3382	10860	3488	74.40	20	20.70	CHANGED	lulRPE+lpl...................ss...s....s..sl....sGpVpphtahGspshht.lclsssphhhs...ttssst........ht..hGcpVtlsasscsshlh	..............................lulRPE...c.l.pl........................................ss...s........s....sl........pu...p..V..ps...h...p..ah...Gsph......h.......h.....h....l..........c........h........s.......s........s....p....h.......hhs.................ph.sspt............hp............hG..p.p.l.tlsh.s.spphhlh...............................................	0	780	1829	2550
+8235	PF08403	AA_permease_N		Amino acid permease N-terminal	Wuster A	anon	Pfam-B_3112 (release 18.0)	Family	This domain is found to the N-terminus of the amino acid permease domain (Pfam:PF00324) in metazoan Na-K-Cl cotransporters.	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.65	0.72	-4.66	16	266	2009-01-15 18:05:59	2005-08-18 14:58:10	5	5	64	0	109	240	0	70.70	44	7.06	CHANGED	pcstsppshhpshGasTlDsVPplDFYpNouuhut.+tsRPSLp-LHcshccsss...ssht-sssst...sGsss-	............coHosTaYlpTFGHNThDAVPpI-aYRNTuu...s.G..Kh.sRPSLtELH-p.LcKt.......shtDshusG...-uh...............................	0	15	25	55
+8236	PF08404	Baculo_p74_N		Baculoviridae P74 N-terminal	Wuster A	anon	Pfam-B_3059 (release 18.0)	Family	This domain is found at the N-terminus of P74 occlusion-derived virus (ODV) envelope proteins which are required for oral infectivity.  The envelope proteins are found in baculoviruses which are insect pathogens.  The C-terminus of P74 is anchored to the membrane whereas the N-terminus is exposed to the virion surface.  Furthermore P74 is unusual for a virus envelope protein as it lacks an N-terminal localisation signal sequence [1].\	  Also see Pfam:PF04583.	25.00	25.00	27.10	26.60	19.20	19.00	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.88	0.70	-5.66	26	102	2009-01-15 18:05:59	2005-08-18 15:00:00	5	2	71	0	0	99	0	268.90	44	46.86	CHANGED	TslDlhNAspYusphppLcaI.+WRs+FPHIh..IDYsIRsA.oNs.DYYVPssLts+.AlsVcLpFS+cGCESMSCYPasETGsI-h.pTPhG.YTQTS-TuVtYuQ..PACYsLD+AuAsR-GsEtclQosELRYosss+.CIlVDohoKMYhNSPYlRT--Hll+GVDDV.PuFNVts.ssDPlFPE+acGpFN-AYCRRFGRsl..N......suCohpWWEollGFVLGDoIahTFKLLssNVFo-LRsFDYp+PSslLPstPss-upp.lLp-WtssRDsslDh.-hEtpFhphp..shs-lsl...sssppLlYsAppGF	........ThhDhhNAspYu.phtpLpaI.+WRp+hPHIh..IcYplR.A.s.ss.DaYVPstltp+...AlhVcltFS+cGC-.u.MSCY.Pap....ETGsls..pTshs.YTQTS-......Ts..lt.Y...sQ..PACYpLDRuuAh......R-Gt-pplQusEhRYo..spp.ClhV..DohoKMYh...NoPYlRT--HhlhGlDDV.PuFNVts.....s...sDshFP............E+F+GpFNcAYCRRFGRph..N......suCshpWWEollG.FVLGDTlYhThKhlssslao-LRsaDYp+PSs.lLPs..Phssupp..hLspW+ssRDsssch.-hEh.F.p....phsclsh....s...pl.YhAE.Ga...............................	0	0	0	0
+8237	PF08405	Calici_PP_N		Viral polyprotein N-terminal	Wuster A	anon	Pfam-B_4167 (release 18.0)	Family	This domain is found at the N-terminus of non-structural viral polyproteins of the Caliciviridae subfamily.	24.20	24.20	24.40	44.80	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.98	0.70	-5.62	6	386	2009-01-15 18:05:59	2005-08-18 15:01:23	6	4	326	0	0	369	0	351.20	73	21.29	CHANGED	RsspPApEPlIGshLEha-G+IYHYuIYIGpGKslGVHsPpAAhSlA+lslpPIuhWWRssYsPp...hLo.DpLKcLcsEsaPYsAhTNNCYpFCC.VhsLpDTWLpRRhIo.ostFa+PsQDWs+cs.-h.pDSKLchVpDAlLsAlsuLlS+PhKDLLGKLKPLNlLNlLusCDWTFhGlVEsVILLhELFGVFWsPPDVSNFIASLLsDacLQGPEDLAhDLVPlVLGGIGLAlGFT+-KluKhhpSAssuLRAAppLGpYGLEIFpLlhKaFFsu-psc...cTL+sIEsAVIDMEslussplTpLlRDKpSupsYMphLDtEEEKARKLSsKsAsPclVuTTNALlARIShARSAL	......RENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSLaWRP..VYTPQ..YLISPDTLKKLHGETFPYTAFDNNCYAFC.CWVLDLNDSWLSRRMIQRTTGFFRPYQDWNRKPL.PTh.DDSKLKKVANIFLCsLSS...LFTRPI..KDIIGKLRPLNIlNILASCDWTFAGIVESLILLAEL.FGVFWTPPDVSAMIAPLLGDaELQGP.EDLsVELVPVVMGGIGLVLGFTKEK....IGKMLSSAASTLRACKDLG...AYGLEILKLVMKWFFPKKEEAN.ELAMVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINALLARIAAARSLV.................................................................................	0	0	0	0
+8238	PF08406	CbbQ_C		CbbQ/NirQ/NorQ C-terminal 	Wuster A	anon	Pfam-B_3065 (release 18.0)	Family	This domain is found at the C-terminus of proteins of the CbbQ/NirQ/NorQ family of proteins which play a role in the post-translational activation of Rubisco [1].  It is also found in the Thauera aromatica TutH protein which is similar to the CbbQ/NirQ/NorQ family [2], as well as in putative chaperones.  The ATPase family associated with various cellular activities (AAA) Pfam:PF07728 is found in the same bacterial and archaeal proteins as the domain described here.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.42	0.72	-3.97	81	795	2009-01-15 18:05:59	2005-08-18 15:03:12	5	4	655	0	191	519	390	86.40	31	30.94	CHANGED	EspIVucEo.GlspspAtpLVplApplRsL..cGps....L-EGsSTRLLlYAApLlssGlsstpAscsAllcPLTDDs-l..tpuLpchlsuha	............E.tllt.cp..o...u.l.s.c.p.h.s...pplVchupclRsl........ptps.............l-Eus.STRhLlhhupLl.s........t.shss....c....c....A.....hctsllcsL...s..D..-...-h..hpAlhphht...h......................................	0	57	127	167
+8239	PF08407	Chitin_synth_1N		Chitin synthase N-terminal	Wuster A	anon	Pfam-B_1105 (release 18.0)	Family	This is the N-terminal domain of Chitin synthase (Pfam:PF01644).	19.40	19.40	20.90	19.80	18.70	17.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.93	0.72	-4.29	55	491	2009-01-15 18:05:59	2005-08-18 15:04:37	6	9	174	0	331	510	1	79.90	43	8.49	CHANGED	+Rtps..h.....++lp..Lh...pGsllh.D.......sPVPstLhst.lst........psssEFoaMRYTAs.TCDPs-Fs.cpuasLRpt.hYs..RcTELhIslT	.................h...hsh+cVpLh.....pGsllh.D.......sPlPstLhstlsp........sspcEFTHMRY.TAs.TC.DPs..-Fs.cp.........GasLRtt.has..RcTELhIslT...........	0	99	186	287
+8240	PF08408	DNA_pol_B_3		DNA polymerase family B viral insert	Wuster A	anon	Pfam-B_3028 (release 18.0)	Family	This viral domain is found between the exonuclease domain of the DNA polymerase family B (Pfam:PF03104) and the Pfam:PF00136 domain, connecting the two.	24.50	24.50	24.70	24.80	22.00	24.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.11	0.71	-4.33	13	96	2009-01-15 18:05:59	2005-08-18 15:05:26	5	3	53	0	0	90	8	143.70	69	14.78	CHANGED	SKNsFsCsstlc.phssshhphhussssDs+sKlplFu-VLpTGNYlTIs-.claKIlcK.cIt..c-uFpl....sltsspshth....ssh......hsluFGKDDVDLuD..MYtNYsL-hAl-MupYClHDACLCKYLWsYYtIcoKIsAuAsTYlLPQshsFEY	...................SKNAFuChuKVL.scGscEMTFIGDcTTDAKGKAAsFAKVLoTGNYVTVD-.hICKVI+K.DIa..ENGFKV....lLsCPs........NDT......YKLSFGKDDVDLAp..MYKcYNLNIALDMARYCIHDACLCpYLWEYYGVETKTDAGASTYlLPQSMVFEY.........	0	0	0	0
+8241	PF08409	DUF1736		Domain of unknown function (DUF1736)	Wuster A	anon	Pfam-B_4104 (release 18.0)	Family	This domain of unknown function is found in various hypothetical metazoan proteins.	21.70	21.70	22.40	22.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.59	0.72	-4.41	30	412	2009-09-10 21:08:40	2005-08-18 15:06:46	6	202	109	0	252	413	12	78.60	43	10.48	CHANGED	lhsptsPt.FopsDNPsuhssphhoRhLTapYLhsh.NhWLLLhPssLsaDWoMsuIPLl...coltDhRNlholhhasslh...lL	..................hssp.Ph.Fop...DNPAuhus.hhs.RtLTasYLhsh.NhWLLLsPsp..LCaDWoMGsIPLl.....colhDhRNlsTlshassLh...l......	0	83	103	178
+8242	PF08410	DUF1737		Domain of unknown function (DUF1737)	Wuster A	anon	Pfam-B_2030 (release 18.0)	Family	This domain of unknown function is found at the N-terminus of bacterial and viral hypothetical proteins.	20.60	20.60	20.60	24.50	20.30	18.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.67	0.72	-4.19	19	1062	2009-01-15 18:05:59	2005-08-18 15:07:52	5	3	451	0	59	981	214	52.20	58	13.11	CHANGED	M.Kh.....YRhlTusDsusFC+R.VTpALscGWpLaGSPshuasu.tthhtsuQAV....lK-l	...........MshKH......YDVVRAASPS.DLAEK.LTcKLKEGWQPaGuPlAhTs........asLMQAlstE.G.............	0	16	35	46
+8243	PF08411	Exonuc_X-T_C		Exonuclease C-terminal	Wuster A	anon	Pfam-B_3061 (release 18.0)	Family	This bacterial domain is found at the C-terminus of Exodeoxyribonuclease I/Exonuclease I (Pfam:PF00929), which is a single-strand specific DNA nuclease affecting recombination and expression pathways.  The exonuclease I protein in E. coli is associated with DNA deoxyribophosphodiesterase (dRPase) [1].	20.00	20.00	23.80	22.50	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.85	0.70	-5.37	74	1111	2009-09-11 17:37:21	2005-08-18 15:09:21	5	3	1089	6	187	830	1335	260.60	49	55.39	CHANGED	RpKcpltphlDl....hphpPLlHVSGhauut.pussuhlsPlAaHPsNpNAVIshDLstDsssLlc.......Lsu-plRpRLYTc..+s-Ls-s.th.lPlKhlHlNKCP.llAPspsLps..........-sAp.....RL...GlDtptstpphphL+pp....sp.lp-Kltplas.......pp.pas..sssDsDtpLYs.GFF.ussD+pthchlR..pssPppLup..hphsFpDpRltcLLFRYRARNaPcTLsppEpp+Wppa........ppp+Lpssp......hppahppLppLhpp......ppss...cchplLpsLhpYuppL	.......................................................................RsK+KlhsLIDl....spMpP.LVHVSGMFGAh.RGsTSWVuPLA..WH.PcN+NAVIhsDLA.u.Dh.oPLLE.......LDu-sLR-RLYTt........+sDL.u-..pssVP..lKLVHINKC.P.VLA...Ap.T.LcP..........Ec.A-.....RL...GIsRppCLcNLplLRps.....Pp.lREK.VlslFup......tc.sFs....sS-s..VDsQLYs.G.....FF...S-A.DRAsMcIlh....pT.c.PcsLsu................L-lsFsD.cRIc...c...L...LFpYRARNFPs.TLstuE.QpR.WhcH......................RRphhssch...........lpsYtpcLp.Lspp........as.-..Dc......cKluLLKuLapYApc.h......................	0	38	88	143
+8244	PF08412	Ion_trans_N		Ion transport protein N-terminal	Wuster A	anon	Pfam-B_4115 (release 18.0)	Family	This metazoan domain is found to the N-terminus of Pfam:PF00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.	20.60	20.60	20.60	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.69	0.72	-4.67	9	383	2009-01-15 18:05:59	2005-08-18 15:10:34	5	12	89	0	232	371	6	66.70	47	8.90	CHANGED	QhtuhLQPslNKhSL+hFGScKAVpcEQ.Rl+oAGsWIIHPaScF.........................................RFYWDLhMLhLhhuNLIlLPVuITFFpDpsos	................................hh.PtsN+huh+ha.GSpKAl.pEp.R...c.s.u.....G.hW...lI.HPhSsF........................................................RFYWDlhMLllhVuNLIIlP.VuIoF..Fp--.o.....................	1	91	116	169
+8246	PF08414	NADPH_Ox		Respiratory burst NADPH oxidase	Wuster A	anon	Pfam-B_2127 (release 18.0)	Family	This domain is found in plant proteins such as respiratory burst NADPH oxidase proteins which produce reactive oxygen species as a defence mechanism.  It tends to occur to the N-terminus of an EF-hand (Pfam:PF00036), which suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants [1].	21.90	21.90	23.80	23.50	21.30	20.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.26	0.72	-3.92	28	221	2009-01-15 18:05:59	2005-08-18 15:13:29	5	16	30	2	128	252	0	93.50	49	11.45	CHANGED	RLDRo+S.uAt+AL+GL+FIo+ssus..s.G...WspVEpRFsclss..-GhL.RucFucCIGMs..-SKEFAsELFDALARRRplp.s-sIsK-pL+EFW-QIoDQSFDS	...........phcRo+.S.uAt+AL.+GL+Flspssss...t.u...........WtpVEcRFcpLut.....-G.....hLsRscFupCI.........G.Mp......-SKEFAsELFDALuR.RR...plp....h..........ssIoK--L+EFWpQIoDpSFDo......................	0	16	81	103
+8247	PF08415	NRPS		Nonribosomal peptide synthase	Wuster A	anon	Pfam-B_1156 (release 18.0)	Family	This domain is found in bacterial nonribosomal peptide synthetases (NRPS).  NRPS are megaenzymes organised as iterative modules, one for each amino acid to be built into the peptide product [2]. NRPS modules are involved in epothilone biosynthesis (EpoB), myxothiazol biosynthesis (MtaC and MtaD), and other functions [1].  The NRPS domain tends to be found together with the condensation domain (Pfam:PF00668) and the phosphopantetheine binding domain (Pfam:PF00550).	20.90	20.90	20.90	21.60	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-9.06	0.72	-4.20	144	1536	2009-01-15 18:05:59	2005-08-18 15:14:43	5	209	643	0	259	1385	12	57.50	37	3.74	CHANGED	HpthSGVc.VlR.-LsRp.......tsss........shhPVVFTSsLuhss............tsstshhGph...s.aslSQTPQ	.....HppaSGVc.VhR.-Ls+p.....psts.........shhPVVFTSsLGhst.t.............ttspphhGc......saslSQTPQ...............	0	45	137	215
+8248	PF08416	PTB		Phosphotyrosine-binding domain	Wuster A	anon	Pfam-B_3174 (release 18.0)	Family	The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus.  Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix).  Human tensin has actin-binding sites, an SH2 (Pfam:PF00017) domain and a region similar to the tumour suppressor PTEN [1].  The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.56	0.71	-4.24	14	631	2012-10-04 00:02:25	2005-08-18 15:15:56	8	20	96	7	308	1087	1	127.00	29	14.53	CHANGED	QapVpHLsThsh-sppuhpslcDslppLphLsupG+lWsQshllpVsspuloLhD.poKp.L.EpaPLsolpaspsshpsppasS...............lLulVspcsspupssl.HlFp..ElcAp.ltpsIpsslschhhsp.p+	...........................................................thpV...aLsohph-..shs.Ghps.lpc..t....p..h...t.....t........L.......s.......t.........p......s...p......s....h..s.......p.......l..........hh.cVssp.uloLhD.......sp...p..K....................................h....cp.......YP.......lsolp....assh...s..s...p...s...p...pa.ss...............................lhuhVs....+c...s....p........s.....p.....s...s..l....HlFt.....El...c...sppssssI.shlsc.h.st.................................................................................	1	54	78	174
+8249	PF08417	PaO		Pheophorbide a oxygenase	Wuster A	anon	Pfam-B_3102 (release 18.0)	Family	This domain is found in bacterial and plant proteins to the C-terminus of a Rieske 2Fe-2S domain (Pfam:PF00355).  One of the proteins the domain is found in is Pheophorbide a oxygenase (PaO) which seems to be a key regulator of chlorophyll catabolism. Arabidopsis PaO (AtPaO) is a Rieske-type 2Fe-2S enzyme that is identical to Arabidopsis accelerated cell death 1 and homologous to lethal leaf spot 1 (LLS1) of maize [1], in which the domain described here is also found.	20.90	20.90	21.00	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-10.21	0.72	-4.06	29	296	2009-01-15 18:05:59	2005-08-18 15:35:27	7	5	102	0	163	309	25	97.40	26	20.94	CHANGED	F.APChhhps.......................hsscs.tclttlhhChPsu.G+oR.....LlhRashsF......sthhh+lhP...RWapHl.spspVL-pDhhhLctQc+hltp..Gsss......app	...........................................................FhsPChhhsp..........................h.ptppttphhh..lhhslPsus..G+oR.....l...l...hp.hshsF.............................sthhhph..lP......cWa......pHh..st.spVL-pDhhlLptQ-chhhp....s...................	0	41	111	141
+8250	PF08418	Pol_alpha_B_N		DNA polymerase alpha subunit B N-terminal	Wuster A	anon	Pfam-B_4046 (release 18.0)	Family	This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation [1].  Also see Pfam:PF04058.	21.10	21.10	21.80	22.00	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.53	0.70	-4.84	27	272	2009-01-15 18:05:59	2005-08-18 15:36:04	5	9	224	16	181	279	0	213.00	20	36.09	CHANGED	FGsss....ss-llpcLpslhplaslos--Lah+WEuFshpp..spp.p.p.LslpsLcpFccplppphp+pspstht.............tphpphhpssttct.hl.t.sssushhuhhpt.sTPshtpp+h..................................sspsp....htoPsstssstssss................................................................phsp..+pssGpll-olNsch...sps......hsssscsc.....l+lssph-sp+apY+sMh.+L.-uu-VLD-pI-chsplh.pcpaplsp..pFGsPsl.SQ	......................................................ptplltch.plhhhash.s.sp-hh.cW.u....ashph....tts.t.....lshpslptF.cppltp.ph.ppps.ptt.......................p.pthhts..pt..........t......h.s.sss.hhs......p..s.....t..TPpt.tpph.........................................ttt........h..oPs...s.p.st.t.t.......................................................................asp...RtstGpllpshs.s..t.......ps............hss.s.sh.....hc.l.hst..-...h.ph..t...a+.Mh.+L.-t.p-lLsspI-phsp.l.pppaphp...tass....u............................................................................................................................	0	52	97	146
+8253	PF08421	Methyltransf_13		Putative zinc binding domain	Wuster A	anon	Pfam-B_2038 (release 18.0)	Domain	This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.	20.90	20.90	21.10	21.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.95	0.72	-4.48	27	438	2009-01-15 18:05:59	2005-08-18 15:41:25	6	9	358	10	145	436	1072	61.50	34	14.89	CHANGED	CRlCssstlpsllDLGtpPlsssFlss..ttscspshaPLclhhC..psCtLVQLpchlssphhFs	.................CRhCust...h.pshlDLGhsPh.ss.uFlss..tph.s...p..E.s....haPLclhlC......psChLVQLpchhsscplFt...........	0	48	101	122
+8255	PF08423	Rad51		Rad51	Mistry J, Wood V	anon	Pfam-B_684 (release 17.0)	Domain	Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.52	0.70	-5.48	20	2467	2012-10-05 12:31:09	2005-08-18 16:12:14	6	29	887	65	1071	8769	2265	183.50	30	69.83	CHANGED	shGFpTAo-htppRpcllpITTGS+pLDpLL.GGGIETGSITElFGEFRTGKTQLCHTLsVTCQLPl-hGGGEGKshYIDTEGTFRPERllsIAERaGLDspsVL-NlAYARAYNs-HQhpLLtpAuuhMuEu+auLLIVDSsTALYRTDaSGRGELusRQ.+Lu+FLRsLp+LADEFslAVllTNQVlApVDGu.uhFs.uDsKKPIGGpIlAHASTTRLhLRKG+G-pRlCKIYDSPsLPEuEssFuIsppGItDsc	...............................................................................................................hc.t.hh........t..........u.................Gh..........................lsE.................h..h.................G...ts...GKoQl....s.hp.h.s..ls.s......p.....ls.....................t...........t.....G.............h.......t.....u..........t..sha..l.................D.T..........E...s.s.....F......p....s...............p..R.....l........t...........h.................s................p...............t..............................t................................p..........................p..........t.............h........L........p......p...........l............h......h...s......+.......s.............h.....s..........................p........c......p....h............t........l.......l.................t....h......t........t......h......h.............s......c..........p...........t.......h......p....L......l..ll.DSl.....su...h.....a.....R...s......-.........a.............s.........u........c.......s........p...............l........u......t............R.....p.....p.....p......L.....s.....p.....h....h............p..t..L..p.l.u...c...p...a...s...h...A...l.h.l.sNQ.............h.......t..............t..........t....................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	328	556	830
+8256	PF08424	NRDE-2	DUF1740;	NRDE-2, necessary for RNA interference	Mistry J, Wood V	anon	Pfam-B_21376 (release 17.0)	Family	This is a family of eukaryotic proteins.  Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA [1].	26.60	26.60	26.60	26.60	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.99	0.70	-5.55	23	285	2009-01-15 18:05:59	2005-08-18 16:51:24	5	6	205	0	211	292	3	263.90	22	29.68	CHANGED	lpp+stELs+plccsPpDlctWlchlcaQ-plhp.tpp............psppptls-hKLSlhE+ALcp..s...s..sc-cLllthLctssclW.ssccltp+....Wppllpp...........sss..phsLWhpYLcacQup.........FusFohsclhpsahcslctLpsuhsp...................phppshltlFlphshFl+puGasEhAlulaQAhlEhshapPpplptp...........ptlptFppFW-S.tssRlGEssApGWpph.pt..ps.ps..sttp..ssps.........................hap..........uWtpsE...................ppRpspsthPsRs.........s-st--DP.RsllhsDlpshLhhl.s...tpsphpLlpshLtahtlP.h.p.ss	...........................tc..phpptlpppPpshphWhthhtaQc..phht..t..................................ptpht.hh-hKlulh-+Alpt.......p..................s...sp.pLhl..t......hhc...s..t...ph........h...ps.....pt....lhpc...................Wpphl....................pst.......thtLW.pal.hppsp..........hspashsphhpha.pslpthtthtpt.....................................thp..hh.lhhphshahppuGa.....EhuhuhhQuhl-hshhtPt.h.t....................t.ht.ht..FW-s.t.sRhG............-.su.GWt........t..............................t.......................................................................................................hap.Wht.E........................................................ptpt......ttthhPh+s.................sp.tppDs...R...lhhsDlt..Lh.h.p.....t.t...Lh..hh.hhth.......s...........................................................	0	77	117	173
+8258	PF08426	ICE2		ICE2	Mistry J, Wood V	anon	manual	Family	ICE2 is a fungal ER protein which has been shown to play an important role in forming/maintaining the cortical ER [1].  It has also bee identified as a protein which is necessary for nuclear inner membrane targeting [2].	25.00	25.00	32.80	27.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.45	0.70	-5.87	16	140	2009-01-15 18:05:59	2005-08-18 17:08:01	5	2	127	0	104	136	0	388.20	36	93.55	CHANGED	lRshhushYLhlllloIPlAFDVGGlsCGLuFSlTLFshYFlhoTl+llst+pp...ahhhsSllYY..sQahlIPoLLhhFLShass-p.tt................................p..s...hhhhhpthVc.....sWchhLspSTPlFTLLEGFCoLLlIQAlGpss+WLshc..+SDoWlIhSLlsSGulITuohYaLYRIYshP.aplshhsAoLLGhsLohshsLGhaGIlSG+GShlESSLhFAYlV+CIYEIFPchupsAopslhphhppsh.tshpsplP...................................lPP.....................Ihssloplh+hlo.olPsShpslaphhh.hAhpoloPulllsLsaRIhVFYuATRIIPulpcsushs..........................................................................pcssspllphlYhYSPCIlIAVYTHLlLQYpGpLts-LslW.....ha.....................p.phllcuWpFWNWlNlhsTllLYAsELhuu	................................................................................phh.ushaLh.hlloIPlAFDVGGhpCGLuaSloLhhhYFhhohl+lhs.cpu.......hhh..h..s..sl..lhh..sQahlIPuLLhh.LstFSsDs.ss.............................................................t.h.......ppp.....sh..ahahhptllp.....sWchlLpaSoPlFpLhEGFsoLLlIQAsGQhsR.WL..ssc..pS-..oW.hIs.LlhSuulIouul.YaLaRlh.hP..tlosh.sAsLlGsslTssshLshaGIsSu+GsslESS...LLFAYlVhClYpIhschtsos.s.tth......s...spp.phP.................................................slPP.....................................lIhss....h.o.slh+hlo.....sLPs.lpshhphlh.hAhpsloPullIsLsYRlhVhYuATRIIPAlpcsus.ps..p.sp....tp....................................................................................................................................................................................................................................................pcs.ssp.hlthL.aaSPsILIAVYTpLlh.Qa.up..t.t.shh.........h.......................phsssuhshWpWhNlhsThhLYAsELhh.s......................	0	26	58	89
+8259	PF08427	DUF1741		Domain of unknown function (DUF1741)	Mistry J, Wood V	anon	Pfam-B_35314 (release 17.0)	Domain	This is a eukaryotic domain of unknown function.	20.30	20.30	21.80	21.60	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.51	0.70	-4.90	13	205	2009-01-15 18:05:59	2005-08-18 17:17:45	5	4	175	0	150	199	1	213.60	36	35.35	CHANGED	Ph.sspsRsLuTslLDlhl-sIsaNL+++LssslYslsluIlhRlloYhscs+lRLsYHWpELWpsLLoLl+FL..sohso-Lpsp.....splppLsppllNllAhhlosGDoFLPossuYD-LFYKllcsupllscF+shhtppsp.s......ss..h....................................hsulssLluVspHFpshlh............t.sups.........ppppLoscpVpclIKpsY-TLolphp-uLstap+acEus.hcshhK+hsRssVsDsRthl	...................................s.ssRsLssslLDlhl-hIspphh.+chshcLYhhCltllhRlLsY.p.+s.+lR..L...p.Y.pWpELWpuL.lsLl+FL.......ho.p.ss..Lhsp.......sIh.sLshplVNLhshhlohGDTFLPoPsSYD-L...........aYcllchtplhsphhshhhhh...spss...........s.th....................................hpulsslhsl.sHapshlt...........................t...t.p......................ph.pplo.ppVhpll+psY..-TLolp.hp-uLstaE+apEts..tshhKchsRshstss+.........................................................................................................................	0	49	76	118
+8260	PF08428	Rib		Rib/alpha-like repeat	Fenech M	anon	Pfam-B_3139 (release 18.0)	Repeat	The region featured in this family is found repeated in a number of bacterial surface proteins, such as Rib (Swiss:P72362) and alpha (Swiss:Q02192). These are expressed by group B streptococci, and Rib is thought to confer protective immunity.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.22	0.72	-4.21	16	1574	2012-10-03 16:25:20	2005-08-18 17:26:22	5	133	326	0	165	1657	10	66.80	33	17.85	CHANGED	loscsGt....sPDss-GIpNhscLPcGTp...Y.......sWcs...........sPDsosPGcKsusVVVTYPDGSpD-VsVsVpVss	.....................................................ps..ut.......pP.s.sp.-.sI.......p..N.........h......ss...L.....P.....c.....G....Tp.........h.................sacs.............................s.DT.s......s.s.G.c.p.s......up.VsVTYPD..GS...p.....-......p......V...s...V.sVpVh.....................	0	21	54	149
+8261	PF08429	PLU-1		PLU-1-like protein	Fenech M	anon	Pfam-B_4023 (release 18.0)	Family	Sequences in this family bear similarity to the central region of PLU-1 (Swiss:Q9Y3Q5). This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer [1]. This region is found in various other Jumonji/ARID domain-containing proteins (see Pfam:PF02373, Pfam:PF01388).	24.30	24.30	25.50	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.98	0.70	-5.55	30	546	2009-01-15 18:05:59	2005-08-18 18:47:40	6	64	236	0	309	488	4	291.60	26	21.73	CHANGED	-sWtp+scchLc...pss+ssLcsL+sLlsEuEchtas...................s-L.ppL+shVppAcphlcpAppllspKppsR.......p+stts.............................p...sp..hslpplppLlcphpsLshsssp.lspLcchhppl-pFppcApphLpp......sshshtclcpLl-pGpshsl-lPElstLcphlcpt+Wh-cspcths.h..............hol......c-lccLl-.pGtpls...spspchhtcLpchlshu-pWEc+Acch.....................Ls.........t.p.hshspLpulhppu..ps...........lPlslssltpLcshLp+u+p......atpplpsl..p...........sspphPphc-lcslhtpucsLssph.pphppLE.....pplpptpsWp-+us+hFhptNush.slLp	.............................................................ptWhtphpthLp....tt+.sL.ph+sLhp-uc..p..h.as..............................spL.ppLpthhpcscphsp.utthlst.ppppp...........p.............................................................................................t..hslpc...lpthl.pp.h...sLsh.sh.sp.htt.lcphhpplcpappcupphLtp.......ptss...........t........p........lp............pLl-.upp.......h...sl.-...l.PplttLp...p.t.l.p.p.t.+.Whccsppthttst........................................hoL......p.hcpLlc...tGhtls......ssscc.ths.....c........Lp...c.lLshucpW-cKAc.h...............................................................Lp................p.p.hshspL.csllpps..pp.............................................l.P.s.l.....ss.ht....sLcphlp+A+t........................Whtplctl....p.................................stpphshhcp.LptLh.ttu..c..s...lssth.pth..plE............tltpscsWpcp....stphFhptsu.h.plLp.............................................................................................................................................	0	82	140	232
+8262	PF08430	Fork_head_N		Forkhead N-terminal region	Fenech M	anon	Pfam-B_3191 (release 18.0)	Family	The region described in this family is found towards the N-terminus of various eukaryotic fork head/HNF-3-related transcription factors (which contain the Pfam:PF00250 domain). These proteins play key roles in embryogenesis, maintenance of differentiated cell states, and tumorigenesis [1].	21.60	21.60	21.60	21.80	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.63	0.71	-3.77	29	224	2009-01-15 18:05:59	2005-08-19 10:58:52	7	3	94	0	100	197	0	126.60	31	30.04	CHANGED	shYs-s.ppsYSss..s...........sMNoMsshhshssh....ts.............................s.sM.uhss....suhus.sshsuMssGhsuhhs......s.huhsshus.shussu.hus.hust.sss..hssluP..tshsts.s......s..thpR.....ssKsYRRSYTHA	..........................................hY.ts..psYos...s........................sMNs...Mso.hhshssh.........s...........................shsM.uhhs......suhus....sh.suMusussuhh............uhhuhsuhus...slusus..hus.hust.sus...hsuluP..tshssh.s.....s.utlptsR......ssKTYRRSYTHA........	0	17	26	59
+8264	PF08432	Vfa1	DUF1742;	AAA-ATPase Vps4-associated protein 1	Mistry J, Wood V	anon	manual	Family	Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole [1].  There is a CCCH zinc finger at the N-terminus.	21.30	21.30	21.30	21.60	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.55	0.71	-4.26	24	142	2009-11-11 09:10:55	2005-08-19 15:36:58	5	2	129	0	107	136	1	164.20	33	88.68	CHANGED	NhYphR+VAsssuKuChICaKPoooVLlossst.................DFFYlCssHLpDc.pFso....Plhss.chttsctKpctlpcclccl...KK-hEpcpphhpch.tph..............Kcs-cpK-cc................sspcs.-ppccpcpcptcpchpslppshst.tsphsp...ps+hasLcp.............shaptRlcphpptch......tccpp......pclpp.sshFPslPp	..........................NhYphR+VAppsu+sChICaKPoooVLl..s...ssst......................DaFY.sC..HLp..Dp.tFss...........Phhsp...ph.t..st.......tctcthpc-l-+l...cp..-hE....p+ppt.tpct.ppt...............ccpcppK-pc................ppppp.....sppspp...pp.cpppcphpp..hppphst..........sphsp.......psRhapLpp..................shap.Rlpch+....phph......s+cpt............pcl.tp..thFPSsPp...............................................	0	25	55	86
+8265	PF08433	KTI12		Chromatin associated protein KTI12 	Mistry J, Wood V	anon	Pfam-B_11625 (release 17.0)	Family	This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II [1].  The Elongator complex has histone acetyltransferase activity.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.68	0.70	-5.19	21	408	2012-10-05 12:31:09	2005-08-22 14:09:07	5	14	303	13	286	1745	907	262.30	25	83.50	CHANGED	MPLlllTGhPsSGKoThAcpLtphhpc............pshsVhlls.D-slt.....hs+cs..Yt.cSppEKthRuplhSsVcRsLS+s.slVIlDuhNYIKGaRYpLaChAKsspTsaCllashss.................h-hshpaN.....pp+sps.........................................................ass-ll-pLh.RaEcPsspsRWDpPLFolh......sccshsh......................--Ihpsl................hppptLpPNpuThspPh.usssaLpcLDppTppllstIhpt.ppssssstlp..............hs.ssp..lphsts...holspLpRlRRpFlshs+........psh-h-+lhshFl-aLN	.................................Ms.Ll.l.hsGhPsSGKo.phut..p..l..t..p..h...hpt..............................................................t.h....p.l..h...h.ls...ppsht.......................ht.pps.......a............t..........s.s............t..........t..E....+.....h....R......u...............h....h....u.....t....l........p......R.......t......l.........s.................c........p.....s..........l.V....I........l.D..u....h..N.....Y.I..K...G..aR......Y....p..L.a.C...h.u..........+..t...h..p......s..s..h....C.h.......l..a.s...s.ss.........................................h-ps.hphN.............ppR...t..p.t......................................................................................................................................................a..s..t...-.h...hc...p...Lh...h..R.......a......E...p.P...s.s.p.s.R..WDp...PLhsl...........sptp....s..h...............................................................................................................ppl.h.ps.l.........................................................................hp.t.t............s..pt.u..T.......t.t....sh.......s.......s..s.......shLa.p..lDp.tTppllstlhp.....t..t.p..t........h..s..h...........................................................h.t.................hsh.pLpch++palth.p..................t......ph...Fhthl..................................................................................................................................................................	0	108	158	233
+8266	PF08434	CLCA_N		Calcium-activated chloride channel	Wuster A	anon	Pfam-B_3091 (release 18.0)	Family	The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells [1] and has four or five putative transmembrane regions.  Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors [2].  The domain described here is found at the N-terminus of CLCAs.	20.30	20.30	21.20	20.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.70	0.70	-5.16	13	295	2009-01-15 18:05:59	2005-08-22 15:35:17	6	15	48	0	190	313	0	228.60	40	29.90	CHANGED	MushpsslF.lLlLaLLpus.ssSL......lpLNNNGYEGIVIAIsPsVPEDEpLIppIK-MVTcASsYLFEATc+RFYF+NVuILIPtoWKu+scYh+PKpEoYcpADVlVAssshttsD-PYThQaGpCGEKGcYIHFTPDFLLsccl.spYGPpGRlFVHEWAHLRWGVFDEYNsDcPFYlutppcIcATRCSssITGpshVhpCQGGSClo.+pC+hDppTGLYEcsCpFlPc+sQotKASIMFMQulDSVVEFCsEKsHNpEAPNL	.....................................................hh.hhhl.hll..s.....tssh........lpLpsNGY-slllAIsPs..VPE....D..p...p..lIppIK.....-MlTpASsYLFpATcpRhY.F+sVsILIP...tTWp...s...............p.s.........p.Yt.hs....+..p.E.o........Y...cp...ADVlV....ss..s.t.........hs.D..c.PY......ThQas..tC.G-pGcaIHhTPsFlh.....s....c.....ph....t.Y..G....s.p......G+lhVHEWAHLRWGVFDE..Y...s...p....-.......p.......P........F.Y..h.s.t....p...s....pl.....csT.R........CSstIsG...l..tsp..tssC......p.......Cphs....ot.l.a.c.ttCpF.hPp....p......Q..s.t....p..uSIMF......h...Q...s.lsSVs-FCs.......p.......p.....s.......HNp-APs...............................................	0	89	93	121
+8267	PF08435	Calici_coat_C	Calici_coat_N; 	Calicivirus coat protein C-terminal	Wuster A	anon	Pfam-B_108 (release 18.0)	Family	This is the calicivirus coat protein (Pfam:PF00915) C-terminal region.	25.00	25.00	27.10	30.20	20.80	19.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.40	0.70	-5.06	29	2058	2009-01-15 18:05:59	2005-08-22 15:40:16	6	5	1840	102	0	1400	0	178.20	60	47.19	CHANGED	LTpLDGoPacPs-c.PAPlGhPDFuuphasVhsp.csss........suspucpshlsTssspFsP+LGslphso.s.....sD.hhsstssphoPsulssst...phs.WslPcYuusLs.sspLAPuVsPshsGEplLFFhSplPhs.uG..hssshlsCLLPQEaVpHFhpEpAPupu-lALl+YVNPDTGRsLFEuKLappGFlTl..ssoGssPhslPsNGhFcFsSWVspFYpLtPhGTuuutRR	...............................................................................................................s.shssaDPsE-hPAPLGsPDF.Gpl.GlhoQ.pspt........ssTRuHcAhl.Ts..s.spFsPKLGp.....l.h..sops.....sD..hpstpss+FTP..lGlh.s.....tt.....c.pQWslPpYsut......shpLAPslsP.hsGE.lLhFto.h......ss...hss.........lsCLlPQEWVQHFYQEuA....PuQ.S-VALLRaVNPDTGRVLFEsKLHKsGalTV..ApoGpps.lVlPPNGYFRF-SWVNpFYTLAPhGsG.................	0	0	0	0
+8268	PF08436	DXP_redisom_C		1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal	Wuster A	anon	Pfam-B_445 (release 18.0)	Family	This domain is found to the C-terminus of Pfam:PF02670 domains in bacterial and plant 1-deoxy-D-xylulose 5-phosphate reductoisomerases which catalyse the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH [1].	20.80	20.80	21.10	20.90	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.10	88	3400	2012-10-10 17:06:42	2005-08-22 15:49:37	7	8	3281	79	827	2645	1733	87.00	58	22.25	CHANGED	llPVDSEHsAIFQsLpupstpp......lc+llLTASGGPFRshshcpLpsVTsppALpHPsWsMGtKITIDSAThhNKGLElIEApaLF	...........lLPVDSEHsAIFQsL...........s......p....t....p...pp................lp+llLTASGGPFRsp.s.hccLtsV.......T.......s.......cp....AlpHPNWuMGpKIolDSATMMNKGLElIEA+aLF..........	0	290	560	711
+8269	PF08437	Glyco_transf_8C	Glyco_transf_8N;	Glycosyl transferase family 8 C-terminal	Wuster A	anon	Pfam-B_3038 (release 18.0)	Family	This domain is found at the C-terminus of the Pfam: PF01501 domain in bacterial glucosyltransferase and galactosyltransferase proteins.	19.10	19.10	19.70	19.50	18.10	18.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.70	0.72	-3.95	14	973	2009-01-15 18:05:59	2005-08-22 15:50:24	5	2	442	0	23	344	0	56.50	39	17.19	CHANGED	YPsspYFhpAhpsSPWpchsLhcAsstpph+hphKHhhtpt+YlsGlhshltYhhcK	.....YPsupYFhpA+psSPWcchsh.h.cs.ssppph+hphKHhhtQp+YhsGlhshltYhhcK..............	1	2	6	15
+8270	PF08438	MMR_HSR1_C		GTPase of unknown function C-terminal	Wuster A	anon	Pfam-B_4095 (release 18.0)	Family	This domain is found at the C-terminus of Pfam:PF01926 in archaeal and eukaryotic GTP-binding proteins. The C-terminal domain of the GTP-binding proteins is necessary for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotides.	23.30	23.30	23.60	31.10	22.80	23.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.48	0.72	-3.82	93	341	2009-01-15 18:05:59	2005-08-22 15:51:20	5	8	303	1	227	327	110	110.50	40	25.54	CHANGED	AANKsD.h.s..uccNlc+lpc..............llPsSAtuELuLR+AscsGhIc..YtPGDpcFp...lss-s....................l.scpQcpuL-tI+c.llpcaGu.............TGVQpslspAVa-lLshIsVYPVcc	.....................................................................AhNKhD.hss...........A-cNlp+ltc............ph..ssptlVssSAhuElhLR+hs+pGhIc..YhsGs.-Fp...hsp-s......................l.s-cpcptLEpl+-.V..Lh+aGo................TGVppsLspAs.-lLshlsVYPVcs.........	0	60	135	193
+8271	PF08439	Peptidase_M3_N		Oligopeptidase F	Wuster A	anon	Pfam-B_679 (release 18.0)	Family	This domain is found to the N-terminus of the Pfam:PF01432 domain in bacterial and archaeal proteins including Oligoendopeptidase F.  An example of this protein is Lactococcus lactis PepF [1].	20.70	20.70	20.80	21.40	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.05	0.72	-3.93	182	3235	2009-01-15 18:05:59	2005-08-22 15:52:47	5	3	2039	3	529	2248	391	68.60	25	11.49	CHANGED	Elhpls-pplpphlp.pps...pLptYpahLccl.hcp+sHhLStcpEplLuph.ssshsuhsplashls.uclpF	........................Elhpls-cplpphlp.tp.......cLptYpahlc.pl.hpp+sHhLotcpEclLuph.s-shsusschashhs.uDlpF........................	0	204	361	452
+8272	PF08440	Poty_PP		Potyviridae polyprotein	Wuster A	anon	Pfam-B_237 (release 18.0)	Family	This domain is found in polyproteins of the viral Potyviridae taxon.	23.40	23.40	23.70	23.60	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.58	0.70	-5.33	63	1068	2009-01-15 18:05:59	2005-08-22 15:54:46	5	30	151	0	0	1152	0	222.90	45	9.43	CHANGED	AAFLCFsYGLPV.hTpsVoTulLupCTlcQARTMhpFELoPFahschV+aDGoMHPpIHclLKpaKLR-S-lhLschAIPhpssspWhosp......-Yp+lGsplph.scsl+IPFhs+slP-claEclWcslpcaKs-usFu+lo.SssAsKlAYTLpTDstuIsRTlslI-pLlpcEppKppaFcolsussssutsFSLsu...Iss.slRsRYh+DaopcNIphLppu+uQLhEFpshshchps.ph.........lpsaGsLpsVpaQocpp...lu+tLpL+G+W......stslhspD	......AAhhsFsYsLPV.hTpsVSTsllupsTV+Qs+sh.tFELoPFah.phlpaDGoMHP.lHclLKpaKLR-u.h.Lsc.uIP.phsstWhosp......-YpR.......Gh.plph...cpl+lPFhhpsIPpcLap.lWcslhp.a.KssssFsplp.usshsKlu.YTLpTD..uI.RTlhll-pLltpEhhKpp.Fcshhspss.u..FSl.s...lss.sh+t+hh+DaTtcNIthLpts+uQLhEFpshphshsp.ph..........hpcaGuL.psVaHQspss...huKhLpLKG+WsKoLls+D...........................................	0	0	0	0
+8273	PF08441	Integrin_alpha2		Integrin alpha	Wuster A	anon	Pfam-B_609 (release 18.0)	Family	This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.	33.00	33.00	33.40	33.20	32.90	32.70	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.85	0.70	-5.64	97	1499	2012-10-03 16:25:20	2005-08-23 09:52:25	7	51	113	50	666	1224	1	389.40	20	41.35	CHANGED	uRPVlpl.psslphpPpp..lshpppp....Ct.s.......hsC..hslpsChphpupsh.......stplslshslplD.....ptpthpRshF..................tspppshptphhhhsptpthCp.phphal.p...shcDhloPIslplsasL................t.ttshsslp..PlL.s.t..psshhppplsFt+s...........................................................................................................................................................CGsDs..lC.sDLpL.ssphstp..p............................hllG.ss..pplslplslpN..........pGE.sAYpspLhlph.PssLpatplt..................pt.tp..sC....stppssp......hlsCsl..GsPhhp..ssplphplhasssphst..........tpslphplps...posspps....pssshphplslthtsp.......lpl.pGsspPsphh........................p..spcchGs...tlp.apaplpNpGss...slspsplplphPhphpss........hLlahhplt...............t....C.................sttthsshpl................................ptst.ssspppphphpppphhtp.ttt......................................s.ps....pChplpC	.............................................................................................................................................................................................uRPVlpl...ps...slp.h.pPp..........lshpthp.......Ct.t..............s....hplphChphpspsh...........s.phsl......p.hp.lphD......ttth.tRshF...................spptp.h.ttp..hh..hht.ttp......C..p..pht...hhl...p...............shcD.....hls.....P....I...sl...plsasL......................................p..slt.....PlLs.......t...p..t.........h...ptp..h....a.....p.s.........................................C..GpDp..hC.ssL.pl..psp...hstpp............................hhls.sp..pplslplslpN..........pG.E.sAYpsplhlph.P..s.lpattl............................h..pC.....p.tpps....................h.C.pl..G.p..P.....hhp...ssph..phtlhas.s..s..th.p...............t..pplphpl..p......h......po...p.....s....p..pp..................pps.h..p.hp.h.l...hhts.t..............l.l...pu..spssphh.......................p...........p.pshGs............lp..a.a..p.l...........t...................N....G.....sls.th...lplthPht.h....ps....t..............lla.hhph...........................t.hp..Cp.................t...p..th...................................................................................................................................................................................................................................................................................................................	0	114	162	355
+8274	PF08442	ATP-grasp_2		ATP-grasp domain	Bateman A	anon	Bateman A	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.14	0.71	-4.94	22	4398	2012-10-10 13:17:03	2005-08-23 14:07:01	5	18	3546	33	1434	3767	3414	194.30	40	47.81	CHANGED	sLHEYQuKclhp+aGlsVPpGhVAposE-ApchApcluspshVlKAQVhsGGRGKA.........GGV+lspos-EstchAcchLGppLhThQTs.tGphVpcVhlp-tssIp+EhYlulllDRssppslllASscGGh-IEEVAtcsPEtIhKhslDsthGlpsapARclAhphGhps.c.hppsschlhpLYclFhcpDAohlEINPLVh	............................................................................slHEYQu.K..p.l.h.tp.......a.........G...l.s.ls.pG......hs...s.....to..s..c......EA..............p....s.....A....p....c......l........u...............s....s.........s............h..V..VK...u...Q.l.+..A.GG.RG.Ku.................................GGVKl.s..c....o..h..-.-s.c.t...h..A.pp....h.L..G..p.pL...l....T.h.QT........s.s..p......Gp.....V..ppl...h....l.E..p...s.s........s....I.........t.......+.....E...hYluh.ll.D..R...usp.p..sshhuSs..E.GGh..-.IE...c.VAp...c...s...P.-t.I..h.Kh.s........l.D...P...h....s.G.h.p.s...h..p..u.R.c..l.A.h.p.l....G..l.s..s...p......h...pphschhhsLap.hF..h.-..p..D.h.sl..l..E..INPLl.............................................................................................................................................................	0	451	852	1189
+8275	PF08443	RimK		RimK-like ATP-grasp domain	Bateman A	anon	Bateman A	Domain	This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.07	0.71	-4.82	5	2606	2012-10-10 13:17:03	2005-08-23 14:07:23	6	34	1803	4	917	10880	6158	177.30	31	43.97	CHANGED	AcDKh+ShpLLAKps........IslPsouLuau.-cApchIEclt...uaPlVlKslaGSpGltVhLAcccQuLcull-uh+.hsssI....LlQEFIccuss...cDIRslVVGsEVVuAlcRhuc-G-FRoNLaRGGsuEshslosEEcEIAIKAucAhuLslsGVD.Ilcoc+GLLVhEVNuSPGLcshp+soGINIAtKll-aI	............................................................................................................................................psKhhshplL..tpp.u.................l.s...h......P....h....T....h....h.....s.........t.....s..................c.....s....h....t....c....h...l..c.h.l..........uh.P...lV.lK.....h......h......p......G......o.....p.......G...h.....G....V...h......l.....s......c...s...........p.......p...........s........h.....p.......s......l.....l......c......s.......h.......h......t......h......p......s...t...l...........................ll.Q..E...al.....p..p..s..t.s.............tDl...R.....s..h..V.........l....G..........s...........c.........l........l.........u......A.........h........p........R......p........u........t......c.......G...........c.......a..........+........s........N.......h......c........p...........G.........G....s........s.............p..........h.........h.........p..............l.........o........s..........p........t.....c.....c......l........A...........l.....+........A.....u....c.......s......h.......G.....l.......s......l........s.....G.........V.....D.....l........l.......c.................s.......s.......c.......G........s.......h.....V.h.EV.N..u...s.....P..u.....h..c.u...h...p....t.s.s..s...h...s.l.u.t..hht........................................................................................................................................	0	288	540	763
+8276	PF08444	Gly_acyl_tr_C		Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region	Fenech M, Moxon SJ	anon	Pfam-B_7828 (release 9.0)	Family	This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.01	0.72	-3.97	8	176	2012-10-02 22:59:21	2005-08-23 15:35:18	5	3	37	0	93	173	2	87.10	38	30.37	CHANGED	hClLGPEGTPVSWsLMDQTGElRMuGTLPcYRtQGLls+VhappsptLcKhGFPhYsHVDcsNpshQ+MStsLsHlshPCsWNQWNCsP	.......................hClLsPEGsPVSWslMDQouEhpMuYTlP-YRp.pGhhphlhhp.hsptLpppGa.P.h.YspVtcsNptsh+hhpslta..h...h.P...Cp.WppW.hsP..............	0	7	9	26
+8277	PF08445	FR47		FR47-like protein	Fenech M	anon	Pfam-B_71946 (release 17.0)	Family	The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47 (Swiss:Q9VR51). This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.60	0.72	-4.23	9	870	2012-10-02 22:59:21	2005-08-23 15:35:46	5	14	549	3	377	18220	2313	82.70	21	31.53	CHANGED	slGlhct..chsphsuWhl+..s.Gtluulpshsca+p+GLGshLspuluctIsp.cGpsshshlsssNssupplac+LGFphh...pshal	...............................................................................h.................h....s.......p.....l......s......s....l......h...s...h.s.c..aR...t+..G..h....u....s.t....l....s....t........s....l....s.....p..........p...............l....h.........p......p...........G.....c.......p...........s.......h.......l...h.....s...s....s....s..N...s.......s...u...t....p..l..Y.p..+..l.GFpth...........hhh............................................	0	141	246	325
+8278	PF08446	PAS_2		PAS fold	Bateman A	anon	Pfam-B_437 (Release 18.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	21.40	14.00	21.40	14.80	21.30	13.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.44	0.72	-3.60	41	1308	2012-10-04 01:10:46	2005-08-24 15:19:37	6	52	760	31	297	1415	19	101.80	37	12.43	CHANGED	shhptIQpsGhIQPaGslLAl.-Es....shplluhS-Nss-hLsls................spp........................lGpcl+sLhsssusssLccAhsss-lohlNPlhlp.s+s...su+sFhAllHR....h-..sslll-LEPs	..........s..p.Iphs.shIQPaGshlAl...-...-..t.........s.hpllt.h.SENs.p.hLshs................tt.............................................lG.pslc...s...L.h...s..s.s..s......s.h...t.L.p..p....A.h.s.t....t..c...l....s....h....hs.Pl...h.hp....scs.........ouK...P..F..aAIlHR...........hs.....sulllDhEPs..........................................................	0	79	167	233
+8279	PF08447	PAS_3		PAS fold	Bateman A	anon	Pfam-B_64 (Release 18.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.00	0.72	-3.89	122	12998	2012-10-04 01:10:46	2005-08-24 15:19:44	6	2702	2306	12	5490	23426	1576	87.10	19	13.27	CHANGED	hlhhss.ph..tclhGass.p-h..hst...hhphlHP-Dhtthhpshpp......tht.pst.hpt.-aRhhp.psGphh...Wlpspspsht.spsGpshphhGsh	.......................................h..hhst..ph....hpl..h.G...h...s....p....c......h..................s.................................h..........h..p..h.....l...H...P...-..D......h...p...t...s..t..p...s.h.......pp.............thp..ps....p...s........a..p.......h....c......a..R...l...h...........p....p..........c...G........p...h.p.........Wlp.sp.u.psh..h...s...pp.G.p..h.thhG.......................................	0	1661	3542	4558
+8280	PF08448	PAS_4		PAS fold	Bateman A	anon	Pfam-B_493 (Release 18.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.00	0.72	-4.02	49	13956	2012-10-04 01:10:46	2005-08-24 15:20:11	5	2601	2465	26	5614	38008	2799	109.70	16	17.36	CHANGED	hcshssslhhh....Dt-hphhhsNts......htp.hhthsspphhGcsht..-..hhst.......ttsphppthpcshpsppshphhthhth.......ssp.chhphph..hPlhs.pGp.hhuhhhhspDlTpppp	......................................................................pthss.slh...hh.......D...t.....c......t.....p...h...h..h..s..Nps...................htp....h.....h.....u......h......s.....t......p........p....h......l.......G...c.s.hh.............-.......l.h...s.tt..........................t.t..t....h.....t....p....t......h......p.......p......s.......h........p........s........t.....p......s......h.....p...h...p...t..h.hhh........................ss.p..t...p...h..h...p..h..ph............hP...l.....h.........s.......t.......p.........G.........p....h..........h.......u...l.l..s.h..spDlTcpt.............................................................................	0	1870	3885	4919
+8281	PF08449	UAA		UAA transporter family	Bateman A	anon	Pfam-B_606 (release 18.0)	Family	This family includes transporters with a specificity for UDP-N-acetylglucosamine [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.61	0.70	-5.50	23	1443	2012-10-02 19:55:49	2005-08-25 11:28:56	6	22	332	0	997	3957	210	274.70	19	77.88	CHANGED	hlhshuGlasuhhs.ulh.Ehlhptp.us..............uthlTFsQhlhhshhuhlhthhhp............htppphPh+pYhlhshhhhhssshsNtuLpa.lshPspllh+SuphIssMlhGhll..hpK+YshhcYhushhlolGlhlholhsupsssspptpt.p...............GlhlLshuLhhsuhhushQEpla+pYstss.........pEhlFYophhuhshhhlhhh......pshhhpuhthhh......................phPp.hhhaLlh.slspals.phVahhhsphuuLTsollsTlRKhlSlllSllhFspshohtphlGshlVFhGhhlhshstpptp	.........................................................................................................................................................................h......h..h........s...h.h.....c..h..l....hp....t...........................................s.hls..h....h.p...h..h.....h....h..h..h.....h..u.h..h..h.h....h.ht........................................................tt.hs....h.......h......t....a.....h....h.....h....u....h........h....h.....h....h....s.........h....h....s....p....t......u...L....p....a.....l.s...h...Ps................h...lh..Ku..sp..h.lsl.....h.l.h.u.hll.............ht...+..c..Ys.h.h.c...h.h.....s.sh.....h.ls.hGlhl........h.....s...h..t.ss....p.t...t.t.t....t.t.t.t........................................................................G.hh.h.l..h.h...s..l...h...h....s..u.........h....h.......sh..h.p.......-.p........h..h...p...t...h....t...h..p.s..........................hp.h.h..h.h..s...s....h....h....u..h........hh..h.h...h.h..hh..........................s.t.h..h..p..s..h..t..h.h.....................................................................ph.st....hh.......h.......l....h...h....h....s...h....s..........s....h..h......u........h....h...l......h...h....h....h....t.....h......u......u.l.s.h.shl.....h.s......h......R.K.h....ho.h.l.h.S.........h..l....h....a........s..p.....s...h....o.h..h..t.h..h..uhh.l.lFhuhhh.sh......t......................................................................................................................................................................	0	376	570	831
+8282	PF08450	SGL		SMP-30/Gluconolaconase/LRE-like region	Finn RD, Fenech M	anon	Pfam-B_3630 (release 7.0)	Family	This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30, Swiss:Q15493), gluconolactonase (Swiss:Q01578) and luciferin-regenerating enzyme (LRE, Swiss:Q86DU5). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 (Swiss:P52430) and LRE [1].	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.67	0.70	-5.00	50	3454	2012-10-05 17:30:43	2005-08-26 09:32:17	7	90	1667	66	1425	4351	2023	232.20	22	68.45	CHANGED	LGEGPhWctp...........ppsLaWV......DIhstplaphsssssppp.....................hchss..........hlusls..h...ps..spllluhppul......................hlh..c.......hss........s....phphlsph..........sp.spsRhNDGpsDspGp.hahGoMshsttsst...........GsLYRlsss....tp.....lphhhss.lslsNGluaSsDspthYa.....sDohspp..lhta-hDhssu.lss++sa.hchppts......t....PDGhslDu.-GslWsAha.....suu......plh+asPp.Gc.llpplplP.sp.psTsssF.GGschssLalToAp	......................................................................................................................................................................................................................sEuPha...............p.tt.L......h..as................D.....l............t....t....p.....lh..p....h.....p.....t..s..t..t.....t.h.....................................................h.t..hst...................suh..hh.........tp.........sp.h...lh..s..........t.t.sh......................................................hhh.......s..............t.s..............................t.......ph..p...h.lhs..........................st.thsp..N...D.s.....h.s....c....s................p.G..p....ha.hs.s.....s.h...t...t.....t.tsh............................................utl.ap.lsss......tp..........................l.p.h.l..h...s.s......l..s.h...s.........N..G............ls.a..S..s....D....t..p.......hh..Yh.......................s-..o............h.....s.....pp...............lh.ta......s......h.....s.......p..s.......s..........l...s....s..t......c.hh....hp....hsttt..................................................PD..Gh.s....l......Ds...cG...s.l.a.s.A..h.h...........................su.s..........................tl....h..h..a....s.....P......p....G.......p.......h...l....tp..l.....t......lP....s.....t...t.....s.....s...shsF...u............G.....phppLalos..t.................................................................................................	0	451	825	1164
+8283	PF08451	A_deaminase_N		Adenosine/AMP deaminase N-terminal	Wuster A	anon	Pfam-B_3145 (release 18.0)	Family	This domain is found to the N-terminus of the Adenosine/AMP deaminase domain (Pfam:PF00962) in metazoan proteins such as the Cat eye syndrome critical region protein 1 and its homologues.	21.30	21.30	22.00	21.80	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.98	0.72	-3.96	32	240	2009-01-15 18:05:59	2005-08-26 09:39:06	6	5	76	4	102	235	0	85.10	33	19.39	CHANGED	hLhhshhhs.t.........................................psapppRstlhptEpthplGuclhLspcEppsNphlMp.lKp..cElpcuhhsstpFsPuhHFFcshshIcp.SslFpll	...............................................h.......................................................h.p.Rpthh.p.Ep.hthGs..pl.LsttEttsNphLMs.lKp..pElpcG...............hhss.p....FsPuhHFFcshshIcp.SslFphl.....	0	26	35	71
+8284	PF08452	DNAP_B_exo_N		DNA polymerase family B exonuclease domain, N-terminal	Wuster A	anon	Pfam-B_3196 (release 18.0)	Family	This domain is found in viral DNA polymerases to the N-terminus of DNA polymerase family B exonuclease domains (Pfam:PF03104).	21.00	21.00	21.00	34.50	20.40	17.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.58	0.72	-6.73	0.72	-4.67	6	88	2009-01-15 18:05:59	2005-08-26 09:45:14	5	2	48	0	0	82	0	22.10	77	2.21	CHANGED	M-I+ClNWFEs+G.Ep+FLYLKA	MDVRCINWFES+G.ENRFLYLKS	0	0	0	0
+8285	PF08453	Peptidase_M9_N		Peptidase family M9 N-terminal	Wuster A	anon	Pfam-B_4156 (release 18.0)	Family	This domain is found in microbial collagenase metalloproteases to the N-terminus of Pfam:PF01752.  	23.90	23.90	23.90	27.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.84	0.71	-4.96	34	561	2009-09-11 12:23:32	2005-08-26 09:47:51	5	11	300	3	58	499	2	179.60	32	22.09	CHANGED	hs.hspLsphs.pcLlstlps.hchsslssLFphsssstphhhscs+hpslhstLpppupsYsuss..u+ul.sLsEhLRAuaYltaYs..cplsthsst.hp.chhsulpAhhpNPsFh.ss..............cpQspllpuhshlls..NspppstslstshslLppaN...cshsp.hp.hs..........thsslaplhtGhpas.phht............hhtt	..........................hs.hu-LsphssppLs..chlss...hs.a...p...plssLFphspsshs.hh.scsphpslhstLsppupsYTt-s...u+slpshsEhLRuuaYlta.s..scls.hspt.hp.chhsulcshhpNsshhh.ss..............t-QspVl..suhupLIs..NA.us-s-slssshplLcpaN...cshsphspphs..........tssul.aslMpGhsashp.hh.....................................................................	0	19	31	45
+8286	PF08454	RIH_assoc		RyR and IP3R Homology associated	Wuster A	anon	Pfam-B_4135 (release 18.0)	Family	This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels [1].  There seems to be no known function for this domain [2]. Also see the IP3-binding domain Pfam:PF01365 and Pfam:PF02815.	22.10	22.10	24.00	22.30	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.60	0.72	-4.44	43	718	2009-01-15 18:05:59	2005-08-26 09:51:09	6	72	128	0	390	593	1	120.10	46	3.81	CHANGED	ppp...tppphcl..lppllRhLQLhCEGHNhshQNYlRpQsssc.....sohNllppslclLpsh...........................hh.ths....ppshclhhpsh-oLoEhlQGPCppNQ.sls..cophh-hsssll..........pphp	.......................s....ts.ph..hpslhRFLQLLC.EsHN...p..DhQ.NaLRsQss..p.......Ts.hNllhpTlpaL.plpt.....................................Sspss..ls.hGhh......p+sls.lhpQshpoLTEYhQGPCptNQ......pslA..cSphhDhlsuhl....p.................................................................	0	162	186	280
+8287	PF08455	SNF2_assoc		Bacterial SNF2 helicase associated	Wuster A	anon	Pfam-B_3199 (release 18.0)	Family	This domain is found in bacterial proteins of the SWF/SNF/SWI helicase family to the N-terminus of the SNF2 family N-terminal domain (Pfam:PF00176) and together with the Helicase conserved C-terminal domain (Pfam:PF00271). The function of the domain is not clear [1].	23.60	23.60	23.60	23.70	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.25	0.70	-5.89	42	1037	2009-01-15 18:05:59	2005-08-26 09:53:56	5	6	932	0	142	780	18	354.50	22	33.95	CHANGED	u+hlhlssshhcchlpll.ptpsh......th.h.shp.hthplhc.pchP.lp....Fslpcppp.ph.Lphppt.sh..lh.stphhhhpsslYhlspcppphltslh.phht...spppplpaspcppsphlppllPtLpplG..p.l.lstpl..cphhhpshpschahDphcp.plhsplpacY.G.shplsshpchp....................................phhlhRDhc+Epclhphhcph...............................sFttstpphh.h.ts-cplapFhpptlspLpphG.cVahocsh+slhhhpssp..stlclppp..shL-hsFchssIsppElpplLpulpcpccYY+LcsGphlsL-pcchpchpphlppLphptpchppt.lplst.cuhhlsshL...pshphlphscsFccllpclpp.-chpaplP	..........................................................................................................................................................................................................................+hlhhP.shhpphlphl.th.ph...........hp.pphp.hh.hp.hc...sphs..ht....Fplpch....p...p....h....plpl..pp......php...hh..pht..h.hh..h....ps....p..lY.....h.....lst.pp..hph..l....p.....t.lh....h.ht............tp.t.pp...pl.h...spschsc.hupsLshh...tphG...p..........sh....c..ph.t...h....p...s..h....p....spFah...Dp.............t.....c.....s..cl.phcl..pacY..G...sh.plsshpchp....................................ph.hspDhcpE...pclhp.lh.pt.h...............................uFp.t.s.............p....u...ah..h.....h..p.t-p.lYp.FhpchlPthc..plG.......c..V..hhoc.p...lcplh..hh.s.ssp.....tlplspp..sh..L-....l....p..F..Dhp.....s.....I.s.p.p.ElcpslpuLh.p.ppcaahhpsGpll.h.-....c..-.hp......clpphLpcL......thp.tphps.t.lplst.puh.lsphh.....cp....tsplphs...ppFppLspclppP-c..h............................................................	0	54	97	114
+8288	PF08456	Vmethyltransf_C		Viral methyltransferase C-terminal	Wuster A	anon	Pfam-B_2153 (release 18.0)	Family	This domain is found to the C-terminus of the viral methyltransferase domain (Pfam:PF01660) in single-stranded-RNA positive-strand viruses with no DNA stage in the Virgaviridae family.	25.00	25.00	64.60	64.30	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.50	0.70	-4.92	12	48	2009-01-15 18:05:59	2005-08-26 09:55:58	5	3	14	0	0	53	0	197.10	39	13.47	CHANGED	+VLptLRhph+-plshpslhpsshtKlFGpVShaQ+uL+saApWluas.aGsshlphcslPLYVEIpDRl+LWppts..spsFshshpDl--KlchacEhE+E+cclScplsp-K.....................h....s.csssscssschtthpc.tt+sshp-hhtG......c.......................alppWhpp.pspFshsppps........hhthh..hthlptlh-hhhPshphuslh.s--psptlp	.pVhphLRlphK-sVshtsLhpsAFhKVFGpVShaQ+AL+SFApWluYs.HGossIchpslPLYVEIsDRlKLWpptu.PspsFhLsh-DL-EKh+LaE.pE+E+pclSc+IlppK......hG...................pl...tst-htsschssch..hpcsRt+sshtchhEG......cVsTs...................hlppWsEp.-DHFshstpss......pshh.ah..h.hh+hl.-shhssh.Fuslh.ssDpstthc................	0	0	0	0
+8289	PF08457	Sfi1		Sfi1 spindle body protein	Mistry J, Wood V	anon	Pfam-B_54813 (release 17.0)	Family	This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins [1] which are present in microtubule-organising centres.	21.10	21.10	21.30	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	576	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.56	0.70	-13.25	0.70	-6.12	14	195	2009-01-15 18:05:59	2005-08-26 10:05:18	5	14	148	3	150	209	5	386.70	14	42.23	CHANGED	psh+shlptp.....sscTEcaap+LEcRAuRAR-laLlsKuFs+Wtphup-Elp+TssARRHlLp......h+hFpuWRplT.......sVNEhKup...+FhLp+saptW+p+scc..hcphcppAsphppcclh+psahpWahphst+c............Aspah-apl+++..............uL.aWhcKh+s....sc-clpthcshpc+hslspshphWpp+opsltstppcspshpcpplhpptLppW+hpApLtPhtpplssth-scllppuaspWtcchphhppAp-hcRt+lh+suaTsWpct.LRhpsLpsRh-..-..Rlhhcshh+WhLtpRhpLhQ+l+-pRlppssFssalsshpcphscL.cps-htcchcscclL+upLtpW+sphs.p+chEhtAsthatsRlhppslstW+s+hp+hsplpsa....AcsAchaFlsppslKpW+tAs.pot+cRRppuhtphRRphKhsL.AtcshspW+s+spchtsl-ppAhthtpp+shphshchlcpW+ppshcthpphcpA-.hatcplhpchLh+Wt-pltphpphpppAsth.c.cshtpssstL+KhShRhhp.l+uppcsAcsh+ERp.R+psRuhFctWhp+sc	....................................h........................................................................................................................................................................................................................................................................................................................................h..h.....................................h.......t......h..hhthh.......t.............h.........................hh....h.t........W..p...................h.....t.....t.thh.t.ht.Wt..........................t................p.........hh..........ht.......a......................p................................h...a.........ch.......h.thtp.p...h..h....pthh.....tt..ah....tt.................h....ph.t..tt.......h..t.t...hhpp....thhpthhthWp..p...tht........p...p...hp..........h......u..hh...t.......p...h......hh.thpt....t.h..t.p.ht.p.h...p.h...........ut.p.......hp.....hh...hhpthhp.....W...h..thcp..+ht...phh..t....hppt...h.p...h.pl...tphhph.........Whp....t....h....t.t....ht...hp.p....p.t..t..h..t........h..hhh.th....hthWttth...........t......t..........t........s.....h....t...p....h...h.t.h......hWh.t..h..th..........t.........h...............h.t.ht.h................................................................................................	0	59	93	133
+8290	PF08458	PH_2		Plant pleckstrin homology-like region	Fenech M	anon	Pfam-B_7298 (release 8.0)	Family	This family describes a pleckstrin homology (PH)-like region found in several plant proteins of unknown function.	21.80	21.80	21.90	22.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.36	0.72	-4.12	9	142	2012-10-04 00:02:25	2005-08-26 10:18:09	5	4	18	0	92	132	0	106.40	39	26.64	CHANGED	sELlpRsRpGsL+hKpVuVYINKpuQVhLKLKSKHlGGAFoKKpKslVhuVscplsAW..sG+chhpsu...........chhhFGL+Tu.pGllEFcCcSphcpphWspuVpsLLp.sustc	...................s-Lhp+T+cGsL+h+hVSVYI.N.......+p.u...pVhLKhKS+H.luGshoKKKKsVVhsVpp-lsAW...P..GRc...hh-su..........ccctY.FGL+Ts.pGl.lEF-.Ccs.p.tc.hchWspulppLLphss...p..........	0	11	50	71
+8291	PF08459	UvrC_HhH_N		UvrC Helix-hairpin-helix N-terminal	Wuster A	anon	Pfam-B_288 (release 18.0)	Family	This domain is found in the C subunits of the bacterial and archaeal UvrABC system which catalyses nucleotide excision repair in a multi-step process.  UvrC catalyses the first incision on the fourth or fifth phosphodiester bond 3' and on the eighth phosphodiester bond 5' from the damage that is to be excised [1]. The domain described here is found to the N-terminus of a helix hairpin helix (Pfam:PF00633) motif and also co-occurs with the Pfam:PF01541 catalytic domain which is found at the N-terminus of the same proteins.	21.30	21.30	22.80	24.40	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.85	0.71	-4.68	110	4453	2012-10-02 11:25:59	2005-08-31 14:14:15	6	20	4381	10	982	3406	2670	161.00	40	26.34	CHANGED	LpchLsLs.ph....PpRIEsaDlSHlpGsssVuuhVVFpsGtspKppYR+apIc....h.............stG......DDauuM+EVlpRRa..p+hhcpp........................................hPDLllIDGG+GQlssAhcllc.cLGl..s..ls.llGlAKspccpst...........lhhss......tcsltLspss.sLhllQ+lRDEuHRFAI	.....................................tphLtLs.t.h.....PhRIEsFDhSHh.t.G.ss.s.VuuhVVFps..u.tPpKs-YR+apI+....sl............................................sss.......DDYAuM+EVlpRRa..s+hlc.-.p...........................................................................................................................hPDLIlIDGG+GQlstAppVlp...EL.Gl......s......ls..lhGlAKssc+pss.........................lhhs..s.......t.tcsl....tLs.p.sS.sLaLlQ+lRDEuHRFAI............................	0	335	662	843
+8292	PF08460	SH3_5		Bacterial SH3 domain	Bateman A	anon	Pfam-B_1108 (Release 18.0)	Domain	\N	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.11	0.72	-4.06	15	1610	2012-10-02 18:48:24	2005-08-31 14:30:18	5	87	699	2	109	1038	6	64.90	33	24.53	CHANGED	.thspsGoahhssppsl...+ssPplouPsthhhppGsplhYDpV.hptDGasWluYsshsGsRtYlPl	.............s..hspsGsahhs..p..pssl...+spPpsu.u.s.l...h...s....ha.sGppl.p.Y.Dph.hptDGYp.......WloYh.u.hs.G...p...RRYls.................	1	25	50	77
+8293	PF08462	Carmo_coat_C		Carmovirus coat protein	Wuster A	anon	Pfam-B_4180 (release 18.0)	Family	This domain is found to the C-terminus of the Pfam:PF00729 domain in Carmoviruses.	20.80	20.80	20.80	21.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.40	0.72	-4.09	8	62	2009-01-15 18:05:59	2005-08-31 16:17:01	5	1	4	3	0	62	0	98.80	70	28.49	CHANGED	QASNDKVSDGPTYVVPSVNGNELQLRVVAAGKWCIIVRGTVEGGFTKPTLIGPGISGDVDYESARPIAICELVTQMEGQILKITKTSAEQPLQWVVYRM	........QASNDKVSDGPTYVVPSVNGNELQLRVVAAGKWCIIVRGTVEGGFTKPTLlGPGISGsVDYESA.RPIAlCELVT.QMEGQILpITKTSAEQPLQWVVYRM.	0	0	0	0
+8294	PF08463	EcoEI_R_C		EcoEI R protein C-terminal	Wuster A	anon	Pfam-B_4136 (release 18.0)	Family	The restriction enzyme EcoEI recognises 5'-GAGN(7)ATGC-3' and is composed of the three proteins R, M, and S. The domain described here is found at the C-terminus of the R protein (HsdR) which is required for both nuclease and ATPase activity [1,2].	22.80	22.80	22.80	23.20	22.30	22.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.01	0.71	-4.39	125	1424	2009-01-15 18:05:59	2005-08-31 16:20:10	5	18	1139	0	251	1037	195	157.50	23	17.71	CHANGED	pchpca.tthpp..hlppp.hsshssLpplhss....pphppp.LccLppthh..pt.....h..hstp...pl.p.....................t..sslhsll+plh..uh.-....hhshc-+spp.th..ppah......tpts.....hss.pQtcaLch.............................lhcpht..ppGhh-.....cshphss..Fpp..Gs.tplt..hFt........plpphlpclpctlh	............................................phpcY...scc..hltpp..hss.sshpplaps.....tchppt.lccLpphhh..ct......ltppt..shpp................................thchhchlpcl..uh..s.........hshpER...spp.th....spah...................................sphs.....hsppthphLch.............................llcphh-p.Glh-....hcsLphtP...F.pph..Gs..tl...phFsst.p........ph.pslpclpptl........................	0	75	171	214
+8295	PF08464	Gemini_AC4_5_2		Geminivirus AC4/5 conserved region	Wuster A	anon	Pfam-B_4177 (release 18.0)	Family	This domain is found in replication initiator (Rep) associated proteins such as AC5 in the Geminivirus/Begomovirus.	25.00	25.00	56.30	55.40	22.80	21.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-7.90	0.72	-4.23	17	174	2009-01-15 18:05:59	2005-08-31 16:21:10	5	2	91	0	0	174	0	43.00	59	26.82	CHANGED	MpsIlshhKRLcLThAFTu.tpIhuSlHsVasGLsVHtPVsPs	..MtsIlsthKRLcLThAFTustcIhsSlHsVHsGhuVHGPVsPs.	0	0	0	0
+8296	PF08465	Herpes_TK_C		Thymidine kinase from Herpesvirus C-terminal	Wuster A	anon	Pfam-B_4030 (release 18.0)	Family	This domain is found towards the C terminus in Herpesvirus Thymidine kinases.	20.10	20.10	20.50	32.80	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.38	0.72	-4.44	12	34	2009-09-11 05:18:18	2005-08-31 16:21:50	5	2	26	0	0	33	0	32.70	48	5.80	CHANGED	pFpcDlsGlWspIYsQlh+NsuIKs+hlsWsAL	.pFpDDlsGhWocIYpQlhpNsAIKophlcWsuL..	0	0	0	0
+8297	PF08466	IRK_N		Inward rectifier potassium channel N-terminal	Wuster A	anon	Pfam-B_4080 (release 18.0)	Family	This metazoan domain is found to the N-terminus of the Pfam:PF01007 domain in Inward rectifier potassium channels (KIR2 or IRK2).	25.00	25.00	28.60	27.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.06	0.72	-4.05	5	111	2009-01-15 18:05:59	2005-08-31 16:22:24	5	2	41	8	60	91	0	45.20	67	10.61	CHANGED	MuuuRTNRYSIVSSEE-GL+LuTMuusNGFGNG..KVHTRR+CRSRF	......MuusRsNRYSIVS.S.EEDGh+LsTMu.....sA.NGFG.NG...KV....H.T.RppCRsRF..	0	3	11	28
+8298	PF08467	Luteo_P1-P2		Luteovirus RNA polymerase P1-P2/replicase	Wuster A	anon	Pfam-B_4011 (release 18.0)	Family	This domain is found in RNA-dependent RNA polymerase P1-P2 fusion/replicase proteins in plant Luteoviruses.	20.50	20.50	86.80	86.70	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.21	0.70	-5.65	4	151	2009-01-15 18:05:59	2005-08-31 16:23:28	5	2	10	0	0	154	0	332.90	77	58.24	CHANGED	h.F-.LIsASA+sVKDFISaCYsRh+SlYYuhKRWLhElpGpFcAHDAFVsMCastMhsIE-FEtELAEEauptEsEVp.AcshhKhLVAptu...........sGspcuhsDF..ltuRuGsasPl..............uCcs+Spp..s+s-Kh.pLlccpclh...Es+ht+sY.cEhGcu.hspW.NsL.oRhphlKcstccttcNAKtAp+lss.hptsssIsDhhuhsEVspV-TG.ph.spKshpGEEhspspPhlc.VRRlK..sEstssApsaIpppI+.pN.pL.sus-lShATIsRYs.phsEchcLDlsSpThLhphAMh.VPlPpppDIctthllQSPsARplR-chsVLsSpsF	.hFFElLIGASuKAVKDFISHCYSRLKSIYYSFKRWLMEISGQFKAHDAFVNMCFGHMADIEDFEAELAEEFAEREDEVEEARSLLKLLVAQKS............KoGVTE.AWTDF.FhKSRGGVYAPL.....................SCEPT+QELEsKSEKLE+LLEEQHQF...EVRAAKKYIKEKGRGFINCW.NDLRSRLRLVK-VKDEAKDNA+AAAKIGAEMFAPlslQDLYSFTEVKKVETGLhKEVlKEhNGEEEK+LEPIhE-VRSIKDTAEuRDAASTWITETVKLKNSTL.sADELSLATIARYVENVGDKFKLDIASKTYLKQsAoMSVPIPTsKDIKhKMVLQSPEARA+RERMDVLDSsGF	1	0	0	0
+8299	PF08468	MTS_N		Methyltransferase small domain N-terminal	Wuster A	anon	Pfam-B_4172 (release 18.0)	Family	This domain is found to the N-terminus of the methyltransferase small domain (Pfam:PF05175) in bacterial proteins [1].	21.10	21.10	21.20	21.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.76	0.71	-4.38	19	926	2009-01-15 18:05:59	2005-08-31 16:25:02	6	2	917	1	125	547	57	151.90	52	45.12	CHANGED	SpVlhRphchFps+pVLlAGplpDphPtpLsthspplpsao..aaas.ththptpsslphp..hsspts..t.sDhllhYWPKuKpEAca.LttLlupLshGpEIhlVGENRuGV+Ss-KhLssa.GplsKlDSARRCuLaas.plpppPp.FsLcsaa+pY	...................................................SEVLLRHuDpFppp+lLFAGDlpDDLPAcLc.ss..u..u..+.uc.s.p..........aHHap.sl.up.p.......h...s.-..ss+Fu........Ls.A.p...s..ss...s......u..ssDTLIYYWPKsKsEApFQLhsLLShLPsGs-IFVVGENRSGVRSAEpM.L.A.-Y.u.s.l.sKl.DSARRCGLYaG.+LE+p..Pt..F-h-paWtpY....................	0	20	45	88
+8300	PF08469	NPHI_C		Nucleoside triphosphatase I C-terminal	Wuster A	anon	Pfam-B_4183 (release 18.0)	Family	This viral domain is found to the C-terminus of Poxvirus nucleoside triphosphatase phosphohydrolase I (NPH I, [1]) together with the helicase conserved C-terminal domain (Pfam:PF00271).	21.00	21.00	21.60	21.00	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.83	0.71	-4.31	13	67	2009-01-15 18:05:59	2005-08-31 16:26:02	5	4	49	0	1	57	7	146.10	57	24.20	CHANGED	HhssP.ERRYVNVHFIIA+hosGcsoVD--LL-II+sKS+EFsQLF+VLKpoSIEWIasppKsFpPVDDEoGacsLhSRsl..D-sstosphh+ltpGpNIWYSpSschloIhKGFKscD.G+IYDs-Gsalpshs-N...Pll+IcssKLlYI	...................HVhTPPERRYVNVHFIhARLSNGhsTVDEDLh-IIpoKSK.EFsQLFRVhK+oSlEWI+sspK.DFSPlDsESGWcsLlSRuI..DhssKpshssKLl-GpNIWYSsSsRLhoIp+GFKssD.GRlYDsDGNaLpsMPDN...PlIKIHsGKLlYI.........................................................................	0	1	1	1
+8301	PF08470	NTNH_C		Nontoxic nonhaemagglutinin C-terminal	Wuster A	anon	Pfam-B_4024 (release 18.0)	Family	Bacteria of the Clostridium genus produce protein neurotoxins, which are complexes consisting of neurotoxin (NT), haemagglutinin (HA), nontoxic nonhaemagglutinin (NTNH), and RNA [1, 2].  The domain described here is found at the C-terminus of the NTNH component.	23.90	23.90	24.20	26.30	21.70	23.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.61	7	75	2009-09-10 15:40:16	2005-08-31 16:27:13	5	3	29	2	3	60	1	162.30	68	14.08	CHANGED	NYFssLNNSYIRDuscERLEYNKsYpLYNYVFP-sslhEVppNNNIYLSIpNpsNLNlpssKFKLlslssNKQYVQKWDEVIIsVLsspEKYlDISsENNRIQLVssKssA++hIlNNDIFhsNCLThuaNNKYlsLSh+spNYNWMICNssppIPKtAaLWILK	................NYFpsLNNSYIRDSscERLEYNKTYQLYNYVFs-pslhEVppNNNIYLoINNTNNLNlQuuKFKLlsIssNKQYVQK.....aDEs.IIslLDshEKYlDI.S.EsNRlQLlssKssAKKhIIsNDIFISNCLThoYNsKYlsLShKDcNYNWMICNNspplPKtuYLWhLK.................	0	1	3	3
+8302	PF08471	Ribonuc_red_2_N		Class II vitamin B12-dependent ribonucleotide reductase	Wuster A	anon	Pfam-B_4121 (release 18.0)	Family	This domain is found to the N-terminus of the ribonucleotide reductase barrel domain (Pfam:PF02867).  It occurs in bacterial class II ribonucleotide reductase proteins which depend upon coenzyme B12 (deoxyadenosylcobalamine) [1].	21.60	21.60	22.00	32.80	20.30	19.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.16	0.72	-3.90	47	480	2009-01-15 18:05:59	2005-08-31 16:31:44	5	13	471	0	161	391	512	99.30	52	8.97	CHANGED	DGolVFc.cslEVPppWSQlAsDllAQKYFR..KsGlPt+..................t.t..........hssEsSh+QVhcRlsGsWshWG.hKsGYFso-sDAcsFaDEhtahLhpQ	....DGolVFc.cslEhPstWSpsAusIlApKYFR...psGsPs+...............................................EsSh+QlhDRlssTashhG.hK.sGYFs.S....--DApsFt-ELsahLspQ.......	0	64	112	136
+8303	PF08472	S6PP_C		Sucrose-6-phosphate phosphohydrolase C-terminal	Wuster A	anon	Pfam-B_4159 (release 18.0)	Family	This is the Sucrose-6-phosphate phosphohydrolase (S6PP or SPP) C-terminal domain [1] as found in in plant sucrose phosphatases. These enzymes irreversibly catalyse the last step in sucrose synthesis following the formation of Sucrose-6-Phosphate via sucrose-phosphate synthase (SPS).	20.20	20.20	21.40	21.80	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.88	0.71	-4.54	15	99	2009-01-15 18:05:59	2005-08-31 16:33:44	5	8	33	0	46	100	2	119.50	41	30.38	CHANGED	GPNlSPRDl.DF.s..csKhE......shsPuc-VVKFYLFYEKWRRAEVEpS-ha.....lsslKulscPuGVhlHPSGlEpSL+ssIsu.L+sCYGDKQGKpFRlWVDpllsTplGSsoWLVKFDKWEhsG-ERpCClTTllLosK	...............................GPNlSPRD......l....-h.s........c.c...........shpPuctVV+FYlhaE+WRRuEV.po-th.....hphhKslscssGshlHPuGhEpsL+ssI-s.LtspYGDKpGKpaRhWVDplhssp..huossWL...V+FcpWEh.p.Gpth.sChoohhls.K...............	0	9	32	39
+8304	PF08473	VGCC_alpha2		Neuronal voltage-dependent calcium channel alpha 2acd	Wuster A	anon	Pfam-B_4072 (release 18.0)	Family	This eukaryotic domain has been found in the neuronal voltage-dependent calcium channel (VGCC) alpha 2a, 2c, and 2d subunits.\	 It is also found in other calcium channel alpha-2 delta subunits to the N-terminus of a Cache domain (Pfam:PF02743).	20.80	20.80	20.80	21.00	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.24	0.72	-4.21	2	161	2009-01-15 18:05:59	2005-08-31 16:34:57	6	7	49	0	67	128	0	91.60	59	9.28	CHANGED	LDAEhEs-lKV-IRppMIDGEpuphpF+TLhKSQDERYIDKG.RTYTWoPVsssDYSLALVLPsYSh.YIKAplt-TITQA+........SEoL	......LDAELEs-.K.EIR+pMIDGcsG-+p.h+TLVKSp...DE.....RYIDcssRTYTWsPVpGTDY....S....L..uLVLPs.YShaYIpAp...lp-sIhQs+.h......................................	0	5	12	32
+8305	PF08474	MYT1		Myelin transcription factor 1	Wuster A	anon	Pfam-B_4029 (release 18.0)	Family	This domain is found in the myelin transcription factor 1 (MYT1) of chordates.  MYT1 contains C2HC zinc finger domains (Pfam:PF01530) and is expressed in developing neurons of the central nervous system [1] where it is involved in the selection of neuronal precursor cells [2].	20.60	20.60	20.70	22.00	17.70	20.30	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.82	0.70	-4.89	3	273	2009-01-15 18:05:59	2005-08-31 17:44:20	6	25	37	0	104	204	0	181.60	45	24.52	CHANGED	YRsNVAsTTPRANLAKELEKFSKVoFDYASFDAQVFGKRhlAPKlQTu-sSPKuaQcAKPFsKssSPcSSsoSSYV+SSSSssSu..GupspSTsptSSFDYoQDuEAAHM.AATAILNLSTRCREMP-NLSTKPQDL.soKusDIEVDENGTLDLSM+KpRhRDpuhPsoSSCooIsTPpSP.SPQ+p......SSulsNspsaQ.Lu-QDsWDlPlDYT..KP+RlcEEEsKEp-Psshs.upEsLEE++auGEsoIPSPKPKacpRK	.....................a+ss.sssoPRusLuKE.EKauKssF-Y.sSaD....s....p....s...aGKR...hPh.l.p.s...pph.....p.....................................................................................................s.asYsps.EssHh.AAsAILNLSTRChE..h.sp.LSsKPQs.L....s+ss-...hEVDENGTLDLSMpKp+.t-.........ssss....ss.p..ss.pp..............hhsst..Q.hsc.t-tW-..hPlsYo..KspthpE.-.-...c...............-.....................p.......s.....................s...........................................................pt........h--pchstE..............................................	1	4	12	39
+8306	PF08461	HTH_12		Ribonuclease R winged-helix domain	Bateman A	anon	N-terminus of DUF128 family	Domain	This domain is found at the amino terminus of Ribonuclease R and a number of presumed transcriptional regulatory proteins from archaebacteria.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.09	0.72	-4.24	10	1050	2012-10-04 14:01:12	2005-08-31 18:07:20	5	14	1020	0	197	812	52	64.30	54	8.60	CHANGED	lEILsILuEuccPlGAKhIApELcpR.GYcIGERAVRYHL+hLDEcG...LT++lGYu....GR.ITEKGl-EL	.................E.FIL-aL...sc...+c...p...PA.SR-ELAsELplcsEEQl..EuLRRRLRA.MERDGQLVF..T.R....R.Q..C.Y.A................LPE+.LD..........................	1	42	102	154
+8307	PF08475	Baculo_VP91_N		Viral capsid protein 91 N-terminal	Wuster A	anon	Pfam-B_4034 (release 18.0)	Family	This domain is found in Baculoviridae including the nucleopolyhedrovirus at the N-terminus of the viral capsid protein 91 (VP91) [1].	21.80	21.80	159.30	152.90	19.40	17.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.18	0.71	-4.92	27	63	2009-01-15 18:05:59	2005-09-01 10:08:50	5	2	56	0	0	65	0	186.40	39	23.89	CHANGED	LLLlsIlllllFhlhahhIhs-FsEssFssRLpVlpEYh+pss..u-pPlPssLuYVScV..ssshYhVThFsTpsLpphppplHDDphEhFsFlpQpFp......................ss.sspsRVpspssDsscFhl+uDDG..lphcC..PpstpFDss..cCVPlssC.scssGp.hPlTEchlDpLVhN++ss+p....t.sspphHPT	.LLLlAIlllllFslhYlhIhs-FsEssFssRLpVlsEYh+RTN..A-pPhPcsLuYVS-V..spphYhVThFsTssLsslppolHDDphEpFsFlpQpFp......................ssssspsRVpsp.ssDsscFhl+GDDG..hphcC..PsstpFDtst.+CVPlPsCts+ssGp.YPlTEchlDsLVhN++ls+s.....t..ssspthHPT.....	0	0	0	0
+8308	PF08476	VD10_N		Viral D10 N-terminal	Wuster A	anon	Pfam-B_4155 (release 18.0)	Family	This domain is found on the N-terminus of the viral protein D10 (VD10) and the related MutT motif proteins [2].  The VD10 protein is probably essential for virus replication [1] and is often found to the N-terminus of a Pfam:PF00293 domain.	25.00	25.00	52.70	52.70	21.00	17.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.14	0.72	-4.49	7	51	2009-01-15 18:05:59	2005-09-01 10:13:46	5	2	38	0	0	39	0	44.80	58	18.60	CHANGED	hpha.Sslhs.IhppNR+LoKTalhpDssQ+lpsTuFspQpLchh	.MsaY+SSllSpIIKaNRRLuKohIhcDDSQhITLTAFVNQsLasH..	0	0	0	0
+8309	PF08477	Miro		Miro-like protein	Fenech M	anon	Pfam-B_1154 (release 17.0)	Family	Mitochondrial Rho proteins (Miro-1, Swiss:Q8IXI2, and Miro-2, Swiss:Q8IXI1), are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (Pfam:PF00036), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis [1][2].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.61	0.71	-3.61	17	1563	2012-10-05 12:31:09	2005-09-01 11:57:45	8	235	397	7	1022	40314	7022	116.40	20	16.79	CHANGED	+lsllGctssGKoSllpphhttphs.............h-hpssshshp.....hhs.ssst...........h...-.stt.......hthp......hppusuhlllashsctpohpplp.hh.hlsphcp.t.t.lPllllusKhD	.....................................................................+lhllG.s...t..u..sG...K.......o......o..L......l.p..p....h..h..s..t..s.hs....................................................................p..t..h...t...p..s...p...h...s....h.p................h.....h..p..s.p..pph...............................................l...l.h.....-....h....u....s.p...................................t.t.h...t...h.....t.................................hp.......t....s.....c.....s......l....l.....l......l.........a....s......h.........s........c........t................p........o.....h....p..........t.....l..............p.............h.........h..................h...........l.........................p.............h.........p...........t..............................................p.....l......P.....h..l..l.l.u.s+.D......................................................................................................	0	351	546	791
+8310	PF08478	POTRA_1		POTRA domain, FtsQ-type	Fenech M	anon	Pfam-B_1605 (release 7.0)	Family	FtsQ/DivIB bacterial division proteins (Pfam:PF03799) contain an N-terminal POTRA domain (for polypeptide-transport-associated domain). This is found in different types of proteins, usually associated with a transmembrane beta-barrel. FtsQ/DivIB may have chaperone-like roles, which has also been postulated for the POTRA domain in other contexts [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.83	0.72	-3.93	92	3670	2012-10-01 23:48:22	2005-09-01 14:28:48	5	6	3629	6	775	2508	1251	69.80	23	23.53	CHANGED	hslcplplsG.sphlsppclhphhslph..tsshh..tlshsplppplpp.hPalcpspVp+p.aPs.plplplpE+	........................lpplplp...G..s.....ph..sssp..clpps.h.thts.......ssshh...........ph...c...hsth.p..pplcp..hPa....lcpsp.Vc+p..aPs....plplclpEh...............	0	252	491	639
+8311	PF08479	POTRA_2		POTRA domain, ShlB-type	Fenech M	anon	DOMO:DM07489;	Family	The POTRA domain (for polypeptide-transport-associated domain) is found towards the N-terminus of ShlB family proteins (Pfam:PF03865). ShlB is important in the secretion and activation of the haemolysin ShlA. It has been postulated that the POTRA domain has a chaperone-like function over ShlA; it may fold back into the C-terminal beta-barrel channel [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.15	0.72	-4.31	60	1933	2012-10-01 23:48:22	2005-09-01 14:29:39	6	19	922	6	495	1965	284	75.00	24	13.68	CHANGED	aslpplp.lpG....sp.....hls.t.plpplhpshhu+slshsslspLspploshYlp+GYlToRshl.ssQ..sl.ssGt.LplpVlEG	................................................lpplp..lpG........sp...........hstt...tl...p....phh..p....s...h...h..Gc.slshpslp....t....lh...ptlsphhh.s+GYlT...ocshl...P...tQ.....sl..ps.G.h..lplpll.G........................	2	80	250	391
+8312	PF08480	Disaggr_assoc		Disaggregatase related	Wuster A	anon	Pfam-B_4000 (release 18.0)	Family	This domain is found in disaggregatases and several hypothetical proteins of the archaeal genus Methanosarcina. Disaggregatases cause aggregates to separate into single cells [1] and contain parallel beta-helix repeats.  Also see Pfam:PF06848.	20.90	20.90	21.30	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.59	0.71	-4.87	21	34	2012-10-02 14:50:22	2005-09-02 16:30:26	5	12	6	0	31	42	2	190.60	46	24.16	CHANGED	MsDIEIYNNsIasThusGIWlhGYs.uuYoKspAtsVaIHHNhFYsTGTNsuhsWlGGIVssGF.sTLIENNVFDGsYsAAIs.phhspt.....phuPsG..sGYsThVRNNIIsNTh......spusuGoGYGlhNhL.spTHoFlLpNNClYNNuuGsYtsss.SsoDIhsDPhas-pppHDYHLKS.sG+WsGpsWVpDtlsSPCIDAG	........................MsDIEIYNNhIasTaGPGIWlhGht...suYsKsputsVaIHHNhFYsTGTNss...l.....pWlGGIl..sS.GFhs...oLIENNVFDGsYpAAls.phYsst..............thuPsG..oGYT.ThVRNNIIsNTh.R....ppsssGoGYGlh....NhL.scoHsFlLcNNClYNNuuGsYpNss.SsoDI.sDPhFssppp+DYHL+SpsGpWssptWhpc.h.SPCIDsG................................	0	10	10	10
+8313	PF08481	GBS_Bsp-like		GBS Bsp-like repeat	Wuster A	anon	Pfam-B_2122 (release 18.0)	Family	This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp.  Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology [1].	20.00	20.00	20.20	20.10	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.53	0.72	-4.11	50	1326	2009-01-15 18:05:59	2005-09-02 16:33:46	5	104	156	0	188	1240	1	91.80	34	44.51	CHANGED	lslpststpsGsaclhlssl.sssslpsVtlPlWS-pNsQDDlpWYsAs+pssGoapsslchssHpsp.GpYplHlY...shssGphhGlsuTs.hpV	..............................lp.pstpsusa-lhlosl...s..s..p.s.lppVplPsWScpNGQDDlh..WYsAs.+....ps...cGo.YpsslphssHcsptG...pYplH..lY..hhpssGphhG.lsuTshp................................	1	19	53	118
+8314	PF08482	HrpB_C		ATP-dependent helicase C-terminal	Wuster A	anon	Pfam-B_2170 (release 18.0)	Family	This domain is found near the C-terminus of bacterial ATP-dependent helicases such as HrpB.	25.00	25.00	34.60	33.70	23.40	22.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.65	0.71	-4.02	136	1495	2009-01-15 18:05:59	2005-09-02 16:40:32	5	8	1469	0	345	1253	181	132.00	52	16.94	CHANGED	WLtPaLsGlpshsplpplclhsuLpuhL.sWs..ppppL-phsPs+hssPoGs+lsI-Y..............ssst..PsLuVRLQEhFGhspsPplu........sG+lPlhlcLLSPAtRPlQlTpDLsuFWpuoY.t-V+KEMRGRYPKHsWP-DP	..............................WLhPah...s...GlpsLp.sL.psl-lhpALcuLL....sWs...hpQ..+LDp.hPsHasVPoGS+.lsIcY.......................................p.p.-s.....sPsLAVRhQEhFG.s.ssPslA........pG.RVPLlLcLLSPApRPLQlTcDLuuFWpG.uY.t-VpKEM+GRYPKHsWPDDP.............	0	98	201	282
+8315	PF08483	IstB_IS21_ATP	IstB_N;	IstB-like ATP binding N-terminal	Wuster A	anon	Pfam-B_3188 (release 18.0)	Family	This bacterial domain is found to the N-terminus of the Pfam:PF01695 like ATP binding domain in proteins which are putative transposase subunits [1].	20.80	20.80	20.80	20.90	19.60	20.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.00	0.72	-7.05	0.72	-4.27	15	366	2009-01-15 18:05:59	2005-09-02 16:44:39	6	4	226	0	141	347	108	30.00	42	12.31	CHANGED	cEQtspsss.ssLSF-ERLGLLlDRElspR-	.......cQhspPsh.ppLuFEERLuLLl-cEhspR-.....	0	49	87	116
+8316	PF08484	Methyltransf_14		C-methyltransferase C-terminal domain	Wuster A	anon	Pfam-B_2106 (release 18.0)	Family	This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as Pfam:PF08241 or Pfam:PF08242. But this domain is not a methyltransferase.	20.20	20.20	20.20	20.40	20.10	19.80	hmmbuild  --amino -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.92	0.71	-4.68	24	606	2009-01-15 18:05:59	2005-09-02 16:47:16	6	15	457	10	185	611	1437	149.00	30	37.09	CHANGED	lssHGGSlRlhhs+pssppsss....pVscllspEpstGLsphssYppFucRlcph+cpLlsaLtpt+spG+plhGYGAssKGNTlLsaCGlspc.lsalsDpsshKpGpho.PGo+IPIhss-chtshcPDalLlLsWNap-EIlpcppthhstGG+hlhPlP	............................................shaGGSlphhht...t.s.t.......t.......tltthhttE............thslpp..t.ha.tt.Fspcspp.h+ppll.......phLh.p.h+s.pG.+.plsuYGAsuKGs....TL...LNa.s...Gl.ss...-.h.lsallDp.N.PtKpG.+ah..PGo+.IPIhsPc.p..l.pp..p..p.P..D...h..l.ll.L.s.WNhp...-EIhpphp..h.h.p..Guphlh.lP...............................	0	62	135	158
+8317	PF08485	Polysacc_syn_2C		Polysaccharide biosynthesis protein C-terminal	Wuster A	anon	Pfam-B_4073 (release 18.0)	Family	This domain is found to the C-terminus of the Pfam:PF02719 domain in bacterial polysaccharide biosynthesis enzymes including the capsule protein CapD [1] and several putative epimerases/dehydratases.	25.00	25.00	27.40	26.90	23.10	21.70	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.37	0.72	-4.46	50	564	2009-01-15 18:05:59	2005-09-02 16:49:37	5	3	510	0	93	379	199	47.90	54	14.07	CHANGED	DsRDLNYsKYFpEG-pcloph...-DYsSHNTcRLsV-thKcLLLcL-aIp	..DsRDLNYsKYhcpGsc+loph...p-YNSc.NTchLsVEplK-hLLpL-al+....	0	30	61	79
+8318	PF08486	SpoIID		Stage II sporulation protein	Wuster A	anon	Pfam-B_1108 (release 18.0)	Family	This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation [2].  The domain is also found in amidase enhancer proteins.  Amidases, like SpoIID, are cell wall hydrolases [1].	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.40	0.72	-3.72	160	1665	2009-09-10 14:51:08	2005-09-02 16:51:50	5	45	1176	0	415	1429	537	101.00	27	22.16	CHANGED	lhst.ts..php.....hlsp.lslEcYLtGVVuuEMsusas.hE...ALKAQAVAARTYAltphtp........................................ttps...hclss.ospsQVYtu............hpstp...spsp......pAVpsTpGpV.LsY	...........................h....ttphphls.p.lsh.E.-YltuVlssEhs..s..oa..s....hE.............ALKAQAVAuRTa....slp.phtp...................................................ptp.s...h.s.lss...ostsQs.Yts................................hpt....p..hp.........pAlptTtG.llh........................................................	0	188	317	379
+8319	PF08487	VIT		Vault protein inter-alpha-trypsin domain	Wuster A	anon	Pfam-B_2015 (release 18.0)	Family	Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition [1].  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.	21.30	21.30	21.40	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.27	0.71	-4.41	18	1019	2012-10-10 13:59:34	2005-09-02 16:53:43	5	50	337	0	559	925	68	115.20	29	13.23	CHANGED	sslslhShpVcSploSRaA....+TsVoScslNpuspspEstFplplP+pAFIoNFohhIsGpsasGpIK-KptApp.Ypc.ApucG+oAuLV+ssupshEpFpsSV.sVsssoKVsFcLsY.pE	..............................h.lhshplps.pl..suphA....psslspphh....N.ps......s.p.s...h..Es.ha.h.LPc.sAhlssFph...........p..l.s.s.c.s..h..hGplKE.Kp....pA..+p.pYcp.....Ah.s.pG..c...sAuL..l......c.......p.s.s.t.s..h..............F.pssV..Nlsss.sc.lphpLpYt.........................................	0	184	259	391
+8320	PF08488	WAK		Wall-associated kinase	Wuster A	anon	Pfam-B_4138 (release 18.0)	Family	This domain is found together with the eukaryotic protein kinase domain Pfam:PF00069 in plant wall-associated kinases (WAKs) and related proteins.\	\	    WAKs are serine-threonine kinases which might be involved in signalling to the cytoplasm and are required for cell expansion [1].	21.30	21.30	21.60	22.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.65	0.72	-3.71	14	91	2009-01-15 18:05:59	2005-09-02 16:56:30	6	13	11	0	77	112	0	106.30	25	17.43	CHANGED	sp.hCsGhtCCQAp.lPspp.QlIGVsIEsssstspst.tGC+V.AFLTscpYu.SNsT-PEphaupGYssVELGWahpTosppFhss..LuCpNhs-......Yssss...........pChCcY	...................................................t.CsGhsCCQsp.lP.st..h......Q.l......hs.....sslps...p.s..t.s.psp..ssCch.AFLs-c...p.......a...h.h.s...s....hosP.p.ph..p....st.....tYss.l.LsWhh..p...s.......s...s......p....h..........ss......hsCps.p..............hsttp.............pC.Cp.......................................	0	16	52	60
+8321	PF08489	DUF1743		Domain of unknown function (DUF1743)	Wuster A	anon	Pfam-B_4001 (release 18.0)	Family	This domain of unknown function is found in many hypothetical proteins and predicted DNA-binding proteins such as transcription-associated proteins.  It is found in bacteria and archaea.	20.80	20.80	21.10	24.00	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.42	0.71	-4.34	59	216	2009-01-15 18:05:59	2005-09-02 17:02:30	6	3	149	7	150	227	81	117.20	29	29.78	CHANGED	sRGllGAhAulut.................caTaEllsYRhsp.hsp.pRplshpslht.hctcphPhsacslD.htcchllsP+sssPVLaGI...RG.s.tslhpstphl.ps.E.....phpthtIahTNQuTDsH	...s+GllGAhuulut.h..........tcaTaEhlsYRtscphsp.pRplstsolht.hcppshstsacslDhhpcchllsP+ossPVLaGI...RGhs.tslhpstphl.pstE.........hpthtlahTNQsTD.H..............	0	35	93	125
+8322	PF08490	DUF1744		Domain of unknown function (DUF1744)	Mistry J	anon	Pfam-B_5917 (release 18.0)	Domain	This domain is found on the epsilon catalytic subunit of DNA polymerase.  It is found C terminal to Pfam:PF03104 and Pfam:PF00136.	20.40	20.40	21.50	21.10	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.14	0.70	-5.89	17	355	2012-10-02 01:06:00	2005-09-05 12:53:33	7	10	276	0	260	359	14	351.10	32	18.13	CHANGED	slpplYpchhpphhp..t.tphtphh.hs-shsFplphhostcphh+plschlpph+cp+ss.sllhlQSsh.hppltppl.hLspFPhlpl..s.s-sslssLsWQphhu++hlpHaLslusWlsphlphu+YuclPlsNlphDshtFhlDlhaAR+LpppNhVLWWSss.shPDhGGhEpD...phsh.h-clt....PslNsPGhYsslslElplpsLslNolLpSullNEhEGus.s..s.sh..ps..........s.sstssasEsuhsssuhpVL+phlKcWac-.uhpsNshAD.l......lpphhpWVpSssShLaDsuL+halcsLh+KshLQLluEF+RlGuplIaAshN+lllpTsKhslpsuhAYupYll+ul+o+slFpalcLplt+YWDhLlWMDpaNaGGh	...............................................................................................................thatt.h.hh.t.........t..t..h....pphpFc.sp..sshcphhctl..........pchltth+p..p...c.....p...t..s.s....llslQS..s.....................h.........p........pL..h.pt..ls.h.Lp-aPhl..l......................s.....sc..ths...s.............L..sWQphsu+phlp+ahsh.sph.lpp.hhphu.R.......YhclP...lsNl.........t.............D..shahhDlh..aARpLpppshlLWhS..ss.shPDhGGh...EtD.......phhh..h.-pht......................splNpsGsYso..VClELclp.s.LAl.Nsl.L..pSshls-.h..E....G.u..ssh....hs.ss...tt...............................ttss.ss.sta...s-.s.uhssssh.pl.L+pMVp.sWhp-....s......tt...t...N...h...hA....D..........l.+.......hhR.WlpSs..sShL.aDsuL+phlpth......h+KhFhpLluEF.+.RlGupllaAs..hs+lllpTsKtplt.sA........hA.......YspYllpol+s.....+...........lFchlslphpchWchL.lWhDthNaGGh............................................................................	0	97	148	220
+8323	PF08491	SE		Squalene epoxidase	Wuster A	anon	Pfam-B_3107 (release 18.0)	Family	This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.\	      SE was first cloned from Saccharomyces cerevisiae where it was named ERG1.  It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway [1].  Putative transmembrane regions are found to the protein's C-terminus.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.82	0.70	-5.57	13	429	2012-10-10 17:06:42	2005-09-06 09:10:11	5	17	277	0	255	1836	818	239.90	39	51.57	CHANGED	aAsLTlVCDGhFS+FR+sLs.sspspVsSpFVGLlLcNscLPpssHGHVILus.suPlLlYQISSoEsRlLsshsupplPs.sss-ltpYLcssVtPplPccLpsSFhpAl-cu.plRsMPNpaLPAs.sss...pGlllLGDAhNMRHPLTGGGMTVuLsDllLLp+LLpPl...DLsDcpplschlpo.FahtRKshsu.llNTLuhALYpLFsAsscph+.tLcpGCFcYhphGG.ClsGPluLLuGl.P+PhhLhtHFFuVAlYulhp.hhsts.hhhPhulh	...................................................................................................................................AsLTllsDGhhSp....hR..........+..p..lh....s............p.....s.........p.....l.......S..p....F.l.....Gh......l..........s.........s...........h.....P...........h...........s......p........+.G...c.V.l.....L.u.......s...s....s.................Pl......L.hY.p.I.u..s.........p...E.....sR.h......L.l.D..l....s......p..............h.P..s.................p......h.p..p....a..hpp...h..l.......h......P.p...l......P...t..p...l..p.....s.Fh....t...A....l...p......p....u....p..........l.R...o....M.....P..N...p.h....h....P...s...s...........tp........G....hl.llGDAhNMRHPLTGG.GMTVAhsDlll....L....p.p.LL..p.sh...................sL.....t........D.........t..t.........t..l..h...p..h..h.p....p....F.aht.R.K.s....h.s..o..slNhL..A..t.A...LY.pl..Fu.....A.s..................sp...............p.h....+.thppuCFcYhphGG.hssGPluL.Lu.Gl......spP.h.LhhHFFuVAhaulhhhh.h...s.....................................................................................	0	73	152	207
+8324	PF08492	SRP72		SRP72 RNA-binding domain	Zwieb C, Rosenblad MA, Bateman A	anon	Pfam-B_7529 (Release 18.0)	Domain	This region has been identified as the binding site of the SRP72 protein to SRP RNA [1].	25.00	25.00	25.10	26.10	23.50	24.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.43	0.72	-3.60	19	306	2009-01-15 18:05:59	2005-09-06 16:14:07	7	56	261	0	211	304	1	65.40	35	10.29	CHANGED	uupthpppuspt...................................pppc...++KRKs+.hPKsa...s.sshpP.........DPERWLPh+-RSsYRs	..............................................ts...............t............................pthpppc.t...K+KRKs+..LP..Ksa........c.Ps..hsP.........DPERWLPh+..-RSsYRs.....	0	70	114	173
+8325	PF08493	AflR		Aflatoxin regulatory protein	Wuster A	anon	Pfam-B_2081 (release 18.0)	Family	This domain is found in the aflatoxin regulatory protein (AflR) which is involved in the regulation of the biosynthesis of aflatoxin in the fungal genus Aspergillus [1].  It occurs together with the fungal Zn(2)-Cys(6) binuclear cluster domain (Pfam:PF00172).	20.80	20.80	20.90	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.88	0.70	-5.36	5	174	2009-01-15 18:05:59	2005-09-06 19:28:07	5	4	87	0	46	171	1	201.60	32	56.62	CHANGED	GlssPsTsSoPsh.PAsTsAsTTSostPpssspupPsu.p.........PPlsTP...hTPssTSusSPchsp.QSPPspsElWGuhLSPssSs.tsoDLSSLlSVsoDFGsLFuSl.ss.L..pDGsDAD.hhAcuhGsL.sA.hsVuosMpDlFssuAspPPpSscsocsh......CLSlsL-TLp+LFPcAPlGCQ..+sDuE-SSu+LsTIESVISDNKcAhDTlpsIL-CsCAQDGYlLSLVSLIVLKVLGWYlAAARsQsouTscsGshsp-outcSRRsSSSSF......EEcVLH	..................................................................................................................................................................................................................................................................................tP....o....st.sSsh.sp...pSPP...........-h.s..Luss.hus..pssL....SS.L..olso.....pFut.......ht.Sh................cu.cs-...h.A......huuL....s......A.....s.uo.h..s.....h...tsAs.ss.ps....p.hs..................C.hslsLphLhpLa.s....p.ushs...Cp.............hsstp....ss.s.s......p.hhT.....h-....VlpsNKpsh-slpplLsC.s.C..up.Dthlh..hhs.hhh.+llthY.........ss...ht............................................................................................	0	8	26	42
+8326	PF08494	DEAD_assoc		DEAD/H associated	Wuster A	anon	Pfam-B_4150 (release 18.0)	Family	This domain is found in ATP-dependent helicases as well as a number of hypothetical proteins together with the helicase conserved C-terminal domain (Pfam:PF00270) and the Pfam:PF00271 domain.	20.20	20.20	26.50	25.30	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.95	0.71	-4.57	178	1433	2009-01-15 18:05:59	2005-09-06 19:34:35	6	13	1220	0	512	1383	597	187.00	30	15.93	CHANGED	hlPsscplllEph...ptt...stpllhashhG+psppsLuhllut+lscphshslshsssDYuhhlhsspp......................htc.....lhp.......-plpc...hlppslspotlh+p+FRpsAthuGll.+ph..Gt.phsspp.phsushLhps.h...............ct.ss.p.llppshcEshpchhDlsplpphLc+lppu..clplht...hspsSPhAh	................................h.lPsscpLllEphh....chu....caplll+ushG+plppshuhhlutRlppths.h.shs...hsusD.Glslphscs................................sp.shsp........lat.h.........s-pltp......hlpptl.ssSsLhttRFRcsAspuhLls+ptP.G+.c.pshh........Qp....phpustLlcl..t.................pth.P-asllhEohREsLp-hhDlstLtcllp+.lptu....clpltp....sspPSPhA.......................................	1	148	309	423
+8327	PF08495	FIST	DUF1745; 	FIST N domain	Borziak K	anon	Borziak K	Domain	The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [1].	22.10	22.10	22.20	22.10	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.06	0.71	-5.17	138	1150	2009-01-15 18:05:59	2005-09-06 19:37:04	5	35	807	0	415	1000	182	190.60	18	40.54	CHANGED	psslll.lFsosp..astpt..lhptlppths.sstllGCoouGtlss.............ts.sshulslhsh....sssthpshshhh..hs....sshpsutpthpphhpshttt..............................hhllhsDGhssstp...........pllpul.......ptthsslslhGG.AuDshthppohlhs..s........spshps........uslsshlps..............s.hphtshhspGapPh.utthhlTcu..cpphlhElsscP	................................................................................................................................hhh.haso.p...hs.p.h....lhptlp...pths..sstllGsoosu.lss.............................tt.sp.slsl..h..th...ssst..h....p.sh.th.hh......hpp.....s...h...ts.u..t..phhpphhpphtt..............................thhllhhDu.h.ssppp..............tllpsl.......p.tthss..sslhG..G....s....A.us...s..h.....t...h.....p...p....s.h.lht...s....................sphhps...........usl..s.lhlts.............s..hphtshhsp..sa..p.Ph....u.p......hhVTpu...csphlhElsspP................................................	0	135	287	368
+8328	PF08496	Peptidase_S49_N		Peptidase family S49 N-terminal	Wuster A	anon	Pfam-B_4027 (release 18.0)	Family	This domain is found to the N-terminus of bacterial signal peptidases of the S49 family (Pfam:PF01343) [1,2].	22.70	22.70	22.70	22.70	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.84	0.71	-4.43	68	1104	2012-10-02 13:07:06	2005-09-06 19:40:42	5	6	1078	0	169	648	164	149.80	52	44.51	CHANGED	MEFLh-YGLFLAKslTlVlAIlsllshlhuhsp+p+..tpc...GcLclscLsEpYcchccplcttllsccphKthcKppKKpcKt..cpKtpcpt.pt.....................+s+laVLDFcGsIcAs-VsuLREEIoAlLulApsp.DEVLlRLESuGGhVHGYGLAASQL	......................................................MEhLs-YGLFL..AKlVTVVlAIuslshlIls..h..s..pRp+...tp+.......GELclssLoEpY+Eh+-.cLtssL.h-pcptKthcKupKKc.c.Kp-sKutKt.chK.ut..................................sp..pKPRlaVLDFKGShD....A...+EVsSLREEITAlLAsA+sp..DcVlLRLESPGGhVHGYGLAASQL.......................................	0	45	79	128
+8329	PF08497	Radical_SAM_N		Radical SAM N-terminal	Wuster A	anon	Pfam-B_2018 (release 18.0)	Family	This domain tends to occur to the N-terminus of the Pfam:PF04055 domain in hypothetical bacterial proteins.	25.00	25.00	28.30	27.70	22.80	21.70	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-12.02	0.70	-5.49	100	1422	2009-01-15 18:05:59	2005-09-06 19:45:10	5	3	1388	0	288	1078	179	328.40	58	47.65	CHANGED	FLPho+cEMcphGWDphDlIlVTGDAYVDHPSFGhAlIGRlLEupGaRVGIIuQPDW+ss-..sFptLG+PpLFFGVoAGNMDSMVN+YTus+KhRp-DAYTPGG..........csG+RPDRAslVYop+h+EAa.p-l..PlllGGIEASLRRlAHYDYWSDKVRRSlLhDS+ADLLlYGMuE+sllElAc+Ls..........sG..cslps..lpsIRGTuahtpph.........................................................................................................sts...............pshlcLPSaEcVpsD+hhYAcA.+lhatEssPhsu+sLlQtHGs....R........hlhhNPPshPLo...........pcEhDtVYsLPYsRssHPsY........tct.tIPAh-hI+FS	.........................FLPhSRcEM-.pLGW.DuCDlIlVTGDAYVDHPSFGMAIlGRhLEAQGFRVGIIAQPDW...poc.-....DFh+LG+PsLFFGVTAGNMDSMlNRYTA-++lR+DDAYTPss...........huGKRPDRAolVYoQRC+EAa.K.D..V..P.VlLGGIEASLRRhAHYDYWSDpVRRSlLlDSKADhLhaGNGERslVEVA+RLA.................tG.E.s..Isp..........I....pD.....lRsTAhhs+cs...th..h.sp....................................................................................................................h...t...t.shc......cshlhLPSaEcVp....s....D...........K....lLYAHAsRllHpETNPhs.ARALhQ+H.G-.......R........hVWlNPPslPLo...........TEEMDpVFuLPYp.RlPHPsY........Gss.+IPAa-MI+FS....................................................	0	95	193	245
+8330	PF08498	Sterol_MT_C		Sterol methyltransferase C-terminal	Wuster A	anon	Pfam-B_3143 (release 18.0)	Family	This domain is found to the C-terminus of a methyltransferase domain (Pfam:PF08241) in fungal and plant sterol methyltransferases [1].	21.70	21.70	22.60	22.40	21.60	19.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.92	0.72	-4.02	17	347	2009-09-11 17:15:18	2005-09-06 19:48:55	5	6	196	0	227	339	4	65.40	42	18.38	CHANGED	hhohaRhotlGRhlTpshVthlEplGLAPpGSp+VsssLEpAAcuLVtGG+cclFTPMaLaVARKPt	............hohhRhothGRhhs+thltsLEhlGlAPcGopcsschLtpAA-sLVtGGcpplFTPMahhluRKP.....	0	72	142	197
+8331	PF08499	PDEase_I_N		3'5'-cyclic nucleotide phosphodiesterase N-terminal	Wuster A	anon	Pfam-B_3045 (release 18.0)	Family	This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (Pfam:PF00233).	21.60	21.60	22.60	24.90	20.50	21.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.51	0.72	-4.07	6	248	2009-09-11 06:25:11	2005-09-06 19:54:19	7	5	83	0	129	240	0	59.40	69	10.83	CHANGED	RLhDpDDELt-lps-oVPsE..VR-WLASTFTRps...ttpsc-KP+F+SlspulpuGIFs-+	..................RLLDTEDELS-lQoDuVPSE..VRDWLASTFTRQMu..hhtR+uE.E..KP+FRSIVHAVQAGIFVER............	0	21	30	75
+8332	PF08500	Tombus_P33		Tombusvirus p33 	Wuster A	anon	Pfam-B_2139 (release 18.0)	Family	Tombusviruses, which replicate in a wide range of plant hosts, replicate with the help of viral replicase protein including the overlapping p33 and p92 proteins which contain the domain described here [1].	21.80	21.80	22.90	22.10	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.86	0.71	-4.44	10	116	2009-01-15 18:05:59	2005-09-06 20:20:20	5	3	28	0	0	123	0	145.10	43	31.33	CHANGED	plslsshhh.ss.......LP...Rthlpphcphp-Ah-phs-DD-ssssl.h...p..hh.s.....Psschp+lVtps...RRs+YAsKlAtsA+uKVGLLKNocANcLVYQRVhl-.McpcsVRasDRstlLPLAVsA.CFl............pP-uV-EsppllGuS	...............................................................................hhthhh.......lh..s.......hP...Rthhp.hhhhhptpshhps-c-ss-sl.hp......c..hs.Dh.........sso+hTKhltuo...RRtsYAs+lApVARAKVGhLKNo.tNRLlYQRlhl-hMcccsVRhscpcshlPLAlus.CFl.............s-shEEptAlhGs...........................	0	0	0	0
+8333	PF08501	Shikimate_dh_N		Shikimate dehydrogenase substrate binding domain	Bateman A	anon	Pfam-B_99 (release 18.0)	Domain	This domain is the substrate binding domain of shikimate dehydrogenase [1].	21.30	21.30	21.40	21.40	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.64	0.72	-3.92	40	6595	2009-01-15 18:05:59	2005-09-07 11:19:50	6	52	4461	89	1540	4807	2370	81.30	34	25.44	CHANGED	llGpPlp.HShSPhlHNtha....pphGl.sssYhsh-ls........-shpsh.lptlcs....shtGhNVTlPaKpplhshlDclsspActlGAVNTl	.......................lhGpPlt.HShSPhhHsthh................p.p..hG....l..s..h.s.Yh..sh.pls...............p.sh.s.ps..lp..s..hps........hshpGhNVTh..PaK..p.psh......s......h..h....D...c....los.pAph..lGAV.NTl................	2	443	935	1297
+8334	PF08502	LeuA_dimer		LeuA allosteric (dimerisation) domain	Bateman A	anon	Pfam-B_223 (release 18.0)	Domain	This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway [1].\	     This domain, is an internally duplicated structure with a novel fold [1]. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich [1].	24.90	24.90	24.90	24.90	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.61	0.71	-4.36	57	5003	2009-01-15 18:05:59	2005-09-07 12:07:43	5	10	3771	14	1392	3984	3575	133.80	27	25.84	CHANGED	cls-tDlhslhppphtp......................tp.phhcLpphpVhssst.........hssAsVplph....sGch......hptsupGsGPV-AhhpAlp+hlsh...pl...cLh-YplpulssG.sDA.upspVplp.....pc.sph..............hpGhGsssDIlpASscAhlsulNphh	...............................................................plh-t-l.sLhp.p.phhp......................tp...phacLp..p..h...p.l....p...ssss................thss...As..V.p.lps..............sGct....................................hptsupG.s.GPV-AlhpAlpchhsh..............sh.........cLhc......Ypl.pu.l..........s.............p..............G.....s....D.........A......h.u...p...shlplp...................ts..Gcp..........................................hpG.sGlssDIlpAShcAhlsAlNph.h......................	0	459	946	1204
+8335	PF08503	DapH_N	DapD_N;	Tetrahydrodipicolinate succinyltransferase N-terminal	Wuster A	anon	Pfam-B_4065 (release 18.0)	Family	This domain is found at the N-terminus of tetrahydrodipicolinate N-succinyltransferase (DapH) which catalyses the acylation of L-2-amino-6-oxopimelate to 2-N-succinyl-6-oxopimelate in the meso-diaminopimelate/lysine biosynthetic pathway of bacteria, blue-green algae, and plants [1]. The N-terminal domain as defined here contains three alpha-helices and two twisted hairpin loops [2].	21.70	21.70	22.70	22.00	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.62	0.72	-3.86	38	1077	2009-01-15 18:05:59	2005-09-08 09:31:38	5	7	1060	10	128	492	4	81.20	49	34.92	CHANGED	hDApEIIpaIpsuKKpTPVKVYlcGs.Lpslsh..sslcsFsssphtllFG-ap-lcshL-tNpcpIccYclEsDpRNSAlPLLDl	....................hsApEIIpaIusAcKpTPVKVYlcG....p....Lps..lsh...p....olpsF.......Gstp.tVlFG-Wc-lcPhL-s.spphpDYhlEpDtRNSAlPLLDh............	0	42	75	101
+8336	PF08504	RunxI		Runx inhibition domain	Wuster A	anon	Pfam-B_4085 (release 18.0)	Family	This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2).  Its function might be to interact with functional cofactors [1].	20.50	20.50	59.70	59.70	18.00	17.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.64	0.72	-3.57	9	243	2009-01-15 18:05:59	2005-09-08 09:34:32	6	4	51	0	82	197	0	96.50	68	23.14	CHANGED	P.sos.QsQ.....sGsFQosSoPYaLYYGouoGSYQFSMlssG....GG-RSPoRhLssC.TuASTGu......sLhNPs.LssQsD...GVEu-GSHSN.........SPTuhssssRhDEuVWRPY	........................................PGSo.QsQSGPFQoSSoPY.LYYGo.SSG.SY.QFSMVs.......GG-RSPoRML.PPC..TsuSsGo......sLlNPs.LPsQsD...GV-..ADGSHSN.........SPTshssuGRhDEuVWRPY.............	0	4	10	33
+8337	PF08505	MMR1	DSL1;	Mitochondrial Myo2 receptor-related protein	Mistry J, Wood V	anon	manual	Family	Myo2p, a class V myosin, is essential for mitochondrial distribution, class V being vital for organelle distribution in S. cerevisiae. It is the myosin essential for mitochondrial distribution. The established mechanism for distribution of cellular components by class V myosins is that they interact with the cargo at the C-terminal tail domain and transport it along the actin cytoskeleton using the N-terminal motor domain. Cargo-specific myosin receptors act as the link between the myosin tail and cargo. Myo2 binds with MMR1 (mitochondrial Myo2p receptor-related 1), the receptor on cargo, via the C-terminal domain.	23.00	23.00	40.10	40.30	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.84	0.70	-4.32	7	25	2009-09-11 00:16:20	2005-09-08 10:12:00	5	1	24	0	13	22	0	232.40	53	47.39	CHANGED	KLuEhoRsGRSpp...+psS......DohRSsSPhRhthhss............sPKMLKPEYl...............S..ssshsLlSuhltpu..tptsp................................p.tts.s..ss.tts...t.....hhppsh....tQhR.p.............ph.tstpppppps.phpptpsppptpt...lpstptshss.sh.t..o......s.stphpp..tt.....p...hp...sSssuuss.s.hp.pph.pthpls.slPsDcNGFV......sspspR.SaISusuoD.h-.-...Whs	.....KLSELSRGGRSKQ......RRGS......DTMRSVSPIRFQFLNN.................TPKMLKPEYL....................SQTTS..NLPLLSALLKNS..KKTTS................................EuQNSNPDPLNIEKNIIKQS.....IKDKL....EQLRoS...............................EolupVQ+KE+sssSaE...A..css.AEE...sllhpNsEuhLsShs......................PVPAoshcsPpsH..spcsEccuhRlVSuuSTpslS.sElNELPKDLNLD.sLPTDpNGFVQhs.....................tsNNNNNRYSFISSTSTD.YEsE...WpD.....	0	1	4	10
+8338	PF08506	Cse1		Cse1	Mistry J, Wood V	anon	Pfam-B_9217 (release 17.0)	Domain	This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha.  This domain contains HEAT repeats [1].	20.30	20.30	20.50	20.40	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.37	0.70	-5.89	15	650	2012-10-11 20:01:01	2005-09-08 11:24:21	5	15	291	3	453	616	8	300.30	24	31.98	CHANGED	IFKRWRPLF+Ss-LalEIKhVLDpFupPalsLhpsssphlps..sp.sscspLpllFcsLlLlsKlaYDLNsQDlPEFFEDNMpshMsha++YLohsN.PLL-..s---EAulL-+lKuuICEhlpLYsp+Y-E-FpPalppFlpslWsLLso.sospsKYDlLVS+ALpFLTuVAchs+YtplFss-ssLppIsEclllPNlsLR-uDEELFED-PlEYIRRDLEGSDsDTRRRAAsDhL+pLpccaEuhVTsllhpalpphLspYtpsPssNWKtKDsAIYLaoSlAsKGssTps.GVToT.NsLVsls-FFsppIhPDLh.sssssaPILKsDAIKYlasFRsQLsKpQLlplhPlLhpaLtssshVVaTYAAhsI	.......................................................................................................................................................................................................................................................................................................................t......hh+laash..s..s...lP.....h..h..p..p..p..h...t.th....h....t......hhphlp......h.ss.................p.............p.......pp..p..s.......h............hh+..t..........h.hc.....h....t....h........a...........h.......p........+.....Y............t..........-.....................h.......t............hl...............p........a........h....ts.h.h.p.....l.........L....hp...h....p.................p..........c...................h.........l.....s.....ps.....l...p.a.L.s.t..l.sp...t.s..........p..a...t.............h..a.p.t..psplpplhp..c...lIhPshshp-p...D.ElaE--P.EYIR+...c.h....-...............s..p.D.h.s....o..cpAAss.hlp.sL...s...c........p.hc.p..lhthh....h....talpph..Lsp............h...t..t....s.....s..s...t..s...........a..+.p...................K........Ds..AlallsoLA.hh............................h...hh.t.lh.........ch............................................................h...........stsh..hh..a..................................................................................................................................................................	0	138	231	354
+8339	PF08507	COPI_assoc		COPI associated protein	Mistry J, Wood V	anon	manual	Family	Proteins in this family colocalise with COPI vesicle coat proteins [1].	23.80	23.80	23.90	24.20	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.96	0.71	-4.49	24	296	2009-01-15 18:05:59	2005-09-08 11:31:58	5	12	163	0	225	274	1	136.70	20	72.33	CHANGED	chssha..+hlNlssGslhlluGlsphh.........shp.....shllulYhIhhGlhlhhLEa..phP.......lhcYuSFhaSalGRGlFYlhlGsllhts.......shhphlsGhllhllGlhYlsLcahsslp...Ps..sh.........+psshshshpp.....................l	...............................................................h....hh.+lhslssus.l.hll....u.u...l.hphh..........hshp..........shllulYhl....lFulh...lshhEhph.h........................lhcahsFLh....sahGRGlhYlF........lG.slhhst........................thhphlsGhh.lhhhG..lh.alsl.thh..h..............................................h..........................................................	0	111	165	207
+8340	PF08508	DUF1746		Fungal domain of unknown function (DUF1746)	Mistry J, Wood V	anon	manual	Domain	This is a fungal domain of unknown function.	22.30	22.30	22.60	24.60	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.52	0.71	-4.16	14	96	2009-01-15 18:05:59	2005-09-08 11:59:42	5	2	94	0	74	99	0	113.30	37	32.54	CHANGED	sLDhLhashlshlYahDsShlhLhlRuhsQh.hhsPc.................ss.hc.stspshlhsllhu.NlhCllhHhhhuhspuu-u..scGYLHGGlhIsFIGp+sPhS+hcllhhDllllslQllh	......sLDhLhas.LsslYYhDCShhpahlRulsQhhahoPK..................sssht.stspshlhslhhs.Nl..hChlhHhhhuhPpuuEs.........oRGYLHGGlhIDFIGQ+s....PsS+hcLlhlDllllslQllM.................	1	16	38	61
+8341	PF08509	Ad_cyc_g-alpha		Adenylate cyclase G-alpha binding domain	Mistry J, Wood V	anon	manual	Domain	This fungal domain is found in adenylate cyclase and interacts with the alpha subunit of heterotrimeric G proteins [1].	20.10	20.10	20.10	20.40	19.60	20.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.46	0.72	-4.63	19	100	2009-01-15 18:05:59	2005-09-08 12:50:02	6	46	95	0	57	104	0	51.20	30	2.63	CHANGED	scshsPscc.....psssla+LDTNLscMEGIlocP.PhoPhDsshhsstps.cppp	....................tt.sssspt.........ssssla+LDTNLs-M-GIl..spP.PhoPhDsshh.sht.................	0	9	27	45
+8342	PF08510	PIG-P		PIG-P	Mistry J	anon	manual	Family	PIG-P (phosphatidylinositol N-acetylglucosaminyltransferase subunit P) is an enzyme involved in GPI anchor biosynthesis [1].	29.90	29.90	32.10	32.00	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.66	0.71	-4.50	38	303	2009-09-13 01:51:06	2005-09-08 13:13:10	7	8	260	0	208	294	0	126.70	31	50.41	CHANGED	sppchYGFshalhoplsallYllWualPcphLcp.l..................slsYaPs+aWAlAlPsallh.shlhsalshhhhNh.hhT.PLsulps.........lsDphuphtstpphsphpt..t................................................................hsslhDlslstVsclLYt	........phthYGFlhalsothsallYllWualPpsaLpp.l...................Gl.s....YaPs+aWAlAlPsallh.sllhsalhhhuhNh.hhTsP..lsS...lps.........lsDphup.hth.pp..h.tp..t.................................................................................................................................................................................................hsslhDlslstVschha......................................................................	0	62	114	169
+8343	PF08511	COQ9		COQ9	Mistry J, Wood V	anon	manual	Domain	COQ9 is an enzyme that is required for the biosynthesis of coenzyme Q [1].  It may either catalyse a reaction in the coenzyme Q biosynthetic pathway or have a regulatory role.	20.50	20.50	20.80	20.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.48	0.72	-4.47	70	470	2009-09-11 14:22:47	2005-09-08 13:40:06	6	6	434	2	244	450	340	77.20	34	29.11	CHANGED	Ppssspuh+hlaphuDsIWphsGDpSs.DhsWYTKRssLuulYuuThLaa........lsDsStsapsThtFL-RRIcsVhphpch+s	...............................P.phstuhp.lhphsDsIWhhAG........D.pS.s.Dh...sWYTKRssLuulYsoo..L.ah........lpDpS..satcThpFl-cRlpc.lhp.htph..h.................................................	1	74	140	193
+8344	PF08512	Rtt106	DUF1747; 	Histone chaperone Rttp106-like	Mistry J, Wood V	anon	manual	Domain	This family includes Rttp106, a histone chaperone involved in heterochromatin-mediated silencing [1]. This domain belongs to the Pleckstrin homology domain superfamily.	25.50	24.60	26.40	25.60	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-10.20	0.72	-4.00	156	861	2012-10-04 00:02:25	2005-09-08 15:06:29	7	18	317	14	611	854	9	92.10	27	12.65	CHANGED	hhuVpsphtsspG...h...LaPlpc......slla.hcKPhhhlshs-.IptlpapRh.......sshsp+oFDhslhh.+............s.........ttshpFssIspp.-hsslcp.alpppslphpst	........................h..ul.sp.t.ssu...hLhPhsc......ulla.hcp...Pshhlsh--.Iph......lpapRh........shst+sFDhslsh..K..........................s................tpsshphssI..........spp.phs.....slc-.alsspslphpp.h.................	0	210	346	514
+8345	PF08513	LisH		LisH	Mistry J, Wood V	anon	Pfam-B_8344 (release 17.0)	Domain	The LisH (lis homology) domain mediates protein dimerisation and tetramerisation.  The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes.  It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.66	0.73	-6.83	0.73	-4.03	58	1365	2009-01-15 18:05:59	2005-09-08 15:43:56	6	33	318	20	874	1281	4	26.50	35	4.96	CHANGED	ppLNtllhcYLhcpGapcoApsFtpEu	......plNhllhcYLhcpGapcoApsFtpEu....	0	243	438	680
+8346	PF08514	STAG		STAG domain  	Mistry J, Wood V	anon	Pfam-B_4766 (release 17.0)	Family	STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organisms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version [1].	25.00	25.00	25.60	25.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.41	0.71	-4.39	9	489	2009-01-15 18:05:59	2005-09-08 16:00:32	6	8	266	0	290	449	3	117.10	42	10.50	CHANGED	EcsuDYPLssps.paKpF+ssLssFlpsLVppsp.tuhLYDs.....slhDslhshlsuLSsSpsRsaRHTATlsuhplhTuLlsVAhpLspp+-ssp+Ql.EAE+pKtpss+u...Rl-uLhpp....tpc	...............................css-YPLhht.u.....p..aKcF+.....ssFs-.FlpsLlp.pCp..hSllY..Dp......................hhM-sllohLou.LS.....s.S.plRuFRHTuT....L..s..Ah.+.LhTuLVsVA.l.sLoh....p.h.-..sspR...Qh....EAE.+.pKh.hs.p+u.........Rl-.L.p+ht...............................	0	75	127	214
+8347	PF08515	TGF_beta_GS		Transforming growth factor beta type I GS-motif	Wuster A	anon	Pfam-B_630 (release 18.0)	Family	This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation.  The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain.  Point mutations in the GS motif modify the signaling ability of the type I receptor [1].	20.40	20.40	20.50	21.00	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.75	0.72	-7.15	0.72	-4.61	28	639	2009-01-15 18:05:59	2005-09-08 18:27:40	7	10	112	65	307	548	0	28.20	68	5.73	CHANGED	pslpDll-....soSG..SGS.GLPhLVQRTlAR	........poLpDLlp...p.soSG..SGS..GLPLLVQRTlAR..	0	55	82	176
+8348	PF08516	ADAM_CR		ADAM cysteine-rich	Wuster A	anon	Pfam-B_197 (release 18.0)	Family	ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour.  It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity [1].	20.60	20.60	20.60	22.60	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.47	0.71	-4.04	68	1660	2009-01-15 18:05:59	2005-09-08 18:30:05	7	30	158	17	695	1511	0	112.40	31	15.88	CHANGED	sGpPCps.stuYCYsGpC.shspQCpplFGtsAcsAspsCapclNppGsca.GpCGpp...ss...paltCptpDlhCG+LhCpsssphshh.t.....shh.s.h.....p.shhChuhcht.hs........sssDhGhV	..........................sGpPC.p.s....s.....p..uYCYsGpC..s.h.spQCp..plaG......s...A.ps..A....schCapclN.....p......p..G..sp..............a.GsCGpp.....ss..............pahtC...........s..t..pDs.hCG+L.Cpsspp.h.Ph.h...t...p.........tsh...h.....h...........p...th.Chuhth....t...........................................................	0	75	106	268
+8349	PF08517	AXH		Ataxin-1 and HBP1 module (AXH)	Wuster A	anon	Pfam-B_5484 (release 18.0)	Family	AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1).  ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans.  The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression [1].	33.00	33.00	33.50	34.10	31.60	32.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.48	0.71	-3.91	10	201	2009-09-13 12:05:04	2005-09-08 18:31:55	7	7	75	8	118	189	14	116.40	43	20.73	CHANGED	FlKGohlpltcGphK+VEDlpoEDFlpSApcSsDh+lssS............sVp+I-ssu.u.ullpLTFssGs.ccuhlslEspl-HPFFVhs+GWSSCsPshTlppaGLsCpcLpVGDVCLsLshp	............................FhKGohlpht....s..G.....phK+.lcDlt.sEDFhpSsE.hssshclssu...................................................hVs+l-ssp....s............uhlhL...pFss.Gp..ccup.lolEshl-HPFF.VhspGWSShpPphTsthauLPCpcLpVGDV.Cls.sh.h...........	0	22	35	69
+8350	PF08518	GIT_SHD		Spa2 homology domain (SHD) of GIT	Wuster A	anon	Pfam-B_13873 (release 18.0)	Family	GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ).  The function of the CAZ might be to define sites of neurotransmitter release.  Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase [1].	21.10	21.10	21.60	21.20	18.80	20.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-6.99	0.72	-4.59	16	634	2009-01-15 18:05:59	2005-09-08 18:34:00	6	17	202	0	362	665	2	30.50	48	6.87	CHANGED	ARpKLt+LSpppFp-LssDVhsElcRRpppu	....ARpKLtpLssppFp-LshDVasElcRRppt.....	0	92	167	267
+8351	PF08519	RFC1		Replication factor RFC1 C terminal domain	Wood V, Mistry J	anon	Pfam-B_5399 (release 17.0)	Domain	This is the C terminal domain of replication factor C, RFC1.  RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo [1][2].	20.70	20.70	21.30	20.80	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.92	0.71	-4.47	48	368	2009-01-15 18:05:59	2005-09-09 09:02:23	7	16	300	1	251	360	30	150.00	36	16.87	CHANGED	IScGDllschI+uspp..WSLhPhaulhSoVhPuphltGp....hss.phs........FsuWLGpNSppsKhpRhlpElphHhphpo....sss+pplphsYl.shlhpp.LhpPLhppst-.....ulpcllphM-pYhLo+EDh.-sIh-ls......hssppshhpplsoplKuAFTRtYNp	................IS-GDLV-phI+u.........spp..WSLhPsp..AlhSoV.hPup.hhtGp........hss..h.s........FsuW.LGpNSppuKh...pRllpElphHhpl+s....sus+pplp.hsYl.shLhpt.Ll.......pPLt..p....pG.t-......................ulpcVlphMD..sYhLs+EDa.DsIhElu.......hss.pss.hs.plsspsKuAFTRtYNp.............................	0	93	146	211
+8352	PF08520	DUF1748		Fungal protein of unknown function (DUF1748)	Mistry J, Wood V	anon	manual	Family	This is a family of fungal proteins of unknown function.	20.00	20.00	21.70	30.40	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.30	0.72	-4.33	19	138	2009-01-15 18:05:59	2005-09-09 11:04:59	5	2	100	0	108	143	0	70.70	38	74.67	CHANGED	lG+lhHhuhDhsLlSshLAGl+RsTGLo.............................ch-..thpspp.l+salc+YLshGEh.laDpoVAh.suoSsaFcRp	..................................................................lG+lsHauhDhlLl....SshLAGl+RsTGLo..........................................................................p..hs...hhpsps...lcpalcpYLshGEh.lhDpoVAh.hus.SuaFcRp..................................	0	36	70	100
+8353	PF08521	2CSK_N		Two-component sensor kinase N-terminal	Wuster A	anon	Pfam-B_4164 (release 18.0)	Family	This domain is found in bacterial two-component sensor kinases towards the N-terminus.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.81	0.71	-4.69	111	966	2009-01-15 18:05:59	2005-09-09 16:15:29	5	12	521	0	332	893	127	146.10	28	30.67	CHANGED	sLhllhslshhh....sahhAppsAspsaDRsLhuuApslucplph.p....sGp.lplclPhsAh-hlpsss...pD+laYpVhss..............sGphloGh.s-.LPhss....ssssp..........pstaaDsp....a.pGpslRhsslhp......l.t.....s..s...t.lhVpVAcThpsRpthupclh	.....................................PLhlLhshushh....sYhhAhpsAspsaDRsLhuu.Apslu.....cpl...ph...p.......sGp...l....p....l....slPh...sAL-.hh.ptss........sDp.laYpVhss...............sG...chlu.......G...s-.L.Phss.......sssstt......................hsh.aa-sp......a..cG....p..s..lRlAtlhp.............................................slsps......shs............thshltVAEThpsRptlAppl...........................................................................	0	37	144	239
+8354	PF08522	DUF1735		Domain of unknown function (DUF1735)	Wuster A	anon	Pfam-B_2199 (release 18.0)	Family	This domain of unknown function is found in a number of bacterial proteins including acylhydrolases.	21.40	21.40	21.40	21.70	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.97	0.72	-3.60	101	771	2009-01-15 18:05:59	2005-09-09 16:19:03	5	17	106	11	91	680	4	88.10	20	24.59	CHANGED	sspshs.lpl.slDtshlctYN....pp.....pss.sY.phLPps...hYshss..plslpsG..pt.hus.hslphpst.........sh.p.sppYlLPlpls.ssss........tlsps	..............................s.tpshp.lpl..th...Ds....s....h....ls....pYN.........tp.........pss...sY.phLPps...........hYs.l.ss................p........lsl..psG.........ph...hus..lplplpst...............tth.stsppYlLPlpls.ssss.........s.........................	0	57	80	91
+8355	PF08523	MBF1		Multiprotein bridging factor 1	Wuster A	anon	Pfam-B_4141 (release 18.0)	Family	This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2.  It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex [2]. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC [1].  The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants.\	     A helix-turn-helix motif (Pfam:PF01381) is found to its C-terminus.	22.20	22.20	22.70	22.70	21.00	21.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.25	0.72	-3.96	21	391	2009-01-15 18:05:59	2005-09-09 16:30:21	5	2	301	1	230	359	6	71.00	39	48.23	CHANGED	sDW-s.VsVlpK+......sP+sssh+sppslNuApRsGhslpTpKKasuGsNK....ssstspphsKLDc-T-.lphc+V	...............pDW-o.Vsl.lt++.......uPp.sssh+.scpAlNAApRp..GtslpTpKK.auuGsNK........psstspsssKLDc-TE.l+hc+V......................	0	71	126	190
+8356	PF08524	rRNA_processing		rRNA processing	Mistry J, Wood V	anon	manual	Domain	This is a family of proteins that are involved in rRNA processing [1].  In a localisation study they were found to localise to the nucleus and nucleolus [2]. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1 [3]. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli [4].	23.00	23.00	23.00	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.17	0.71	-4.41	7	187	2009-01-15 18:05:59	2005-09-13 09:14:14	6	3	165	0	123	167	0	123.90	23	64.94	CHANGED	Mutstptp..ptKKFT..+Ea....KsK-Ip+sLs++ARL+KpYhKsLccEGYth...PEcp.......p.+..........-s++hppKp+ls..E+tEhtKpRKRpQ+-chptphpcchEcIc...pKppEREp++cpLop+T+pGQPlMGP+INDLLDKIKpDp..Tp	..........................................................................ht............................................................................ptt.........................p..p...............................pp..p.p......c.t.pp...p.p....php.....E.chc.th+pc+...ctp+pchpcp.t...p.c.+cE...t...hc........ptppcRh..cp...p.chlsK+T++GQPlMssphchLLcKIpp....tt......................................	1	46	72	103
+8357	PF08525	OapA_N		Opacity-associated protein A N-terminal motif	Bateman A	anon	Bateman A	Motif	This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1,2]. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.	20.70	20.70	20.70	20.90	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.27	0.72	-4.07	45	1258	2009-01-15 18:05:59	2005-09-14 11:24:36	6	6	755	0	126	489	6	30.60	43	9.32	CHANGED	phhphLP+hH+hhlhslssllll.lllh....Pus	.......hhssLPhhHRhhlhhhsllhls.uhhh....P..........	0	9	34	81
+8358	PF08526	PAD_N		Protein-arginine deiminase (PAD) N-terminal domain	Mifsud W, Bateman A	anon	Pfam-B_2195 (release 6.4)	Domain	This family represents the N-terminal non-catalytic domain of protein-arginine deiminase. This domain has a cupredoxin-like fold.	25.00	25.00	29.00	28.20	24.30	19.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.39	0.71	-4.03	15	190	2009-01-15 18:05:59	2005-09-15 15:51:24	5	6	40	12	84	173	0	106.60	38	17.47	CHANGED	Mu.pphV+LShcpPT+AVCVlGsEhplDlpusAPcsspsFslpGSPGVplplstsss.psccssuss+WPLssss-llVsMsusSssssDsKVpVSYausppchPlupAVLYLT	............Ms.pphl+lshppsspAVCVlGsphhlDlhu...uAPpssp...oFslpuSssVplplshss..ppppss..upp+WPLsss.s-lhlsMsssSssh.sD.s..KVp...loY.Yupcpt.PlspAlLYLT................	0	5	6	18
+8359	PF08527	PAD_M		Protein-arginine deiminase (PAD) middle domain	Mifsud W, Bateman A	anon	Pfam-B_2195 (release 6.4)	Domain	This family represents the central non-catalytic domain of protein-arginine deiminase. This domain has an immunoglobulin-like fold.	20.00	20.00	30.30	28.60	19.90	17.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.06	0.71	-4.83	15	201	2009-09-10 21:19:31	2005-09-15 15:53:00	5	7	49	12	96	184	1	154.90	46	24.89	CHANGED	V-ISLDsDssRsGpV-+sps..cKpoWpWGPsGaGAILLVNCD+Dshtust............DpccsplhshcDLpDMS.MlLpspGPcsLhcsY+LVLHlSpSDuc+lRVFpupsst.............shpsYchVLGPpphoYpVthhsGppchpFYVEGLsFPDssFsGLlSlsVSLL-	......l-ISLDsDhsRsGpVccsps.....cKpsWsWGPpG.GAILLVNCD+D.sstp..s.t............Dspcpc.........lhs..........h.....p.....DLpD..MS.MlLpTpGPspLhs.sacLVLalStuDuc+lRVFpspss.....................sppYptVLG.p.....+hsatVthh....sG..pt-hpFaVEGLsFPDssFsGLlSlpVSLL-........................	0	8	11	27
+8360	PF08528	Whi5	Nrm1; 	Whi5 like	Mistry J, Wood V, Chahwan C, Finn RD	anon	manual	Motif	In metazoans, cyclin-dependent kinase(CDK) dependent phosphorylation of the retinoblastoma Tudor suppressor protein (Rb) alleviates repression of E2F and thereby activates G1/S transcription. The cell size regulator Whi5 appears to be an analogous target of CDK activity during G1 phase [1].	25.00	25.00	25.60	25.10	24.30	24.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.36	0.72	-6.59	0.72	-4.24	24	164	2009-01-15 18:05:59	2005-09-15 16:38:06	6	3	80	0	127	152	0	25.00	42	6.36	CHANGED	pL+sRLphAhaKspsG.pchoLscl	...pL+sRLshAhhKlpsGhpchoLscl..	0	31	71	109
+8361	PF08529	NusA_N		NusA N-terminal domain	Bateman A, Roth A	anon	Pfam-B_407 (Release 18.0)	Domain	This domain represents the RNA polymerase binding domain of NusA.	20.80	20.80	20.90	20.80	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.46	0.71	-4.12	161	4422	2009-09-13 23:45:58	2005-09-20 15:50:34	6	28	4355	5	970	2799	2484	119.80	35	27.93	CHANGED	El.lpslctlscEKsIs+-hlhcAlEpALhsAh......+Kp.a....s......ps.pslcVplDccoG-hclapphpVV..-c...........h.......cs..thplsLp-A...p.phsssh...pl..GDhl.p.pl..ssts..FGRIAAQsAKQVlhQ+l.REAERct	...............El.LtslcslppEKuls+-.hlh-AlEsALhsAh..........K+pa.............s.............pp.tsl+Vpls....c..c.oGc..hclap.p.hpV...V..--.............................Vp......ss...phEIo..LppA......p.......s..s..sh.....................pl..GD.hl..c.cl..ss..ts...FGRlAAQoAKQVIhQ+lREAERt.h...............	0	341	650	828
+8362	PF08530	PepX_C		X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	Bateman A	anon	Bateman A	Domain	This domain contains a beta sandwich domain.	20.70	20.70	20.80	23.00	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.12	0.70	-4.45	53	2418	2012-10-03 19:46:52	2005-09-20 16:49:51	5	23	1578	54	704	2136	679	229.10	17	35.97	CHANGED	Nsh.tshPsVph.sptssps...................................Wps.ssassspspt......phhLs.......t......sthshpttsshssshsh.tthhhss.....................................................tptsshsapotslscshplsGpsplcLplsssss.......ss.plsspLh-l......ssc.....................Gps....................plloc....Ghlplpt+p...p........................................ptlpPsphhslclcLpsosaphtsGcpLclhlsosshsthhhsssstp.hshshsp.........................................pLh	..................................................................................................................................p.P..V.h.h..p..s.tt......................................Wps.h.s..s..aPs......psp.................phaLs...................................s....t.....h.sh..p....t...t...t..sh.s.s.sh.t...........tthhhss.....................................................................................................................tptsshsah.s.sl.s....c..s.......h..clsGpsplcL...p.ls.s..ss.s...............................cs...slh.spLh-l......ssc.................................................Gts....................................thlop...........G..h.l.php...Rp.....p........................................p.lps.s..c..h.hp...lplc.L..s.s.saphptGcpLclslt.uo.s...h...s..h..hh.h.s..s.s....s..hp...hs.h.p.tp.......................................................................................................	0	207	463	615
+8363	PF08531	Bac_rhamnosid_N		Alpha-L-rhamnosidase N-terminal domain	Bateman A	anon	Pfam-B_8527 (release 8.0)	Domain	This family consists of bacterial rhamnosidase A and B enzymes. This domain is probably involved in substrate recognition.	25.00	25.00	25.00	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.73	25	876	2012-10-03 19:46:52	2005-09-20 16:50:02	5	42	361	2	288	895	96	166.90	27	18.23	CHANGED	+pltpARLYlouLGlYEhalNGc+VGDps.........LsPGaTsYc++l.YpTYDVTshLpc.G.cNslGlhVGsGWYssphsh........thp.pthYG.sc.ullupLclpat.DGppcsl.sTDsoW+ss.pGslhtusl....YsG..EsYDARt-.tsWspssaD..DstW....................tssph..............hshPp.stLtAp.ssPl+lsc	..............................................................ltpAplalouhG.......hY-hhl......N....G..p.+.V....G.c..ph.....................LsP.u.hTsY...p.................+................p......lhYp.TY.....DVT..shLpp.....G...pN..........s......lulhl...u.s.GW..ap..s.th.s............................pthhu....sp....s..shhspL.p.lpat.D.......Gs..p.p..h..l...so.........D.......s....o....W+s.......s...p...u.s....l...h.hssl......................asG.......E...p...Y..D..A..R..h..c............t........s....Ws....p..s...s...a..s........c....s..tW.....................................t.ss.h..................................h.t.....s...........l...........................................................................................................	0	134	224	270
+8364	PF08532	Glyco_hydro_42M		Beta-galactosidase trimerisation domain	Bateman A	anon	Pfam-B_2131 (release 5.4)	Domain	This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation [1].	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.22	0.70	-11.17	0.70	-5.17	27	1054	2012-10-03 00:28:14	2005-09-22 16:56:59	5	20	641	2	343	1020	170	197.10	26	29.29	CHANGED	AcVAl....laDa-shWAhc.p..Pp.pshp..........YhpplppaYcshhchGlslDlls.ss.-lst...YclllsPsLahlscshspclpcalcsGGsllhshhSGhhsEssplhhuthPGs....LcclhGlpl.cEh-sLssp.....pp.plp.htGp.......hpsphap-hl...pspsAcs..lApaps..t......Gp.PA....lscpthGc..GpshYlus.....t.spphlppllpplhsc.tslt	....................................................clAl.....laDa-s.....hWuhc...t..........sp...ts.hp............Y.pp.ltpaY.c.sh..hctslssD..ll....s....s...c.....s....-.....hss..............Yc..lll.sPsl..h...hlssshsp+lppaVcs.GG..pll.so.....hhoGhhs-pstl...h.hu......sh.P..Gs....L.....pclhGl.ps...p.-h...s.....sLhss............................ppspl..p....htGp......................................hp...s...p.ha...s.-h....l........ps..p..s......A.ps.....lApYts.......t.ht...........Gt..PA.....................lTpp.t.h....Gp..G.pshYlus..........t.st.t.hh.pthhtplhtphsl.t..............................................................................	0	123	237	290
+8365	PF08533	Glyco_hydro_42C		Beta-galactosidase C-terminal domain	Bateman A	anon	Pfam-B_2131 (release 5.4)	Domain	This domain is found at the C-terminus of beta-galactosidase enzymes that belong to the glycosyl hydrolase 42 family [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.71	0.72	-4.46	26	633	2012-10-02 20:10:03	2005-09-22 17:02:10	5	6	441	2	201	611	24	56.50	23	8.50	CHANGED	Glclpp..h..ttpspahFhhNaoscstplsl....stttppllssph.t.....hslpPhsltVlct	................tVpspt..R..pssps..palFlhNaos.cs.....tp.lsl....stshp-llsu.p...h.hpst............lsLsshsVtllp.................	0	72	140	172
+8367	PF08535	KorB		KorB domain	Bateman A	anon	Pfam-B_20369 (release 10.0)	Domain	This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon [1]. This domain includes the DNA-binding HTH motif [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.72	0.72	-3.83	17	2280	2012-10-04 14:01:12	2005-09-23 14:10:54	5	9	1911	4	384	1460	462	83.50	29	28.74	CHANGED	stGhppu-IA+pLGKstuaVopahuLh-hPsslcphhssthssslcsl.-LtpshccpPpcVpsal.....tstspplTRusl...pchlcsc+psp	..........shTQp-lAcclGKS..RsaIuNhLR...L.L...p.....L...Pp.p.l.pp.hl.p.pG.p..l..o.....t...h..t.....................................................................................ttttthhh...................................................................	0	127	237	310
+8368	PF08536	Whirly	Plant_TF; 	Whirly transcription factor	Mistry J, Pachon DMR	anon	manual	Domain	This family contains the plant whirly transcription factors.	20.00	20.00	22.40	22.10	19.70	18.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.63	0.71	-4.70	4	82	2009-01-15 18:05:59	2005-09-28 13:43:07	6	2	35	12	47	76	4	129.40	45	44.76	CHANGED	ulYKsKuALplcsVtPoFsulsSGshhlcRsGulLLphAsAsusRpYDWppKtsFhLSsTEsupLss.MuupsSCpFFHDPu.tsuustGpVpKuhKVEPhPDGS.GhFlNLoVssu..psscpF.sVPVohuE.Asl+phhs	...................lYKGKAALolpPh.PpFstL-SGuh+ls+cGhlhLpFAP.......A.......l....G.............tRp..YDWs+KQh.FuLSsoElGoLlo...LGsp.-S.sEFFHDP..htpSstGpV+KsLplcPh..sDus.GhFhsLoV.sph...p...s...s-ph...lPlTcuEFuVhhosh.........................................	0	10	32	40
+8369	PF08537	NBP1		Fungal Nap binding protein NBP1	Mistry J, Wood V	anon	manual	Family	NBP1 is a nuclear protein which has been shown in Saccharomyces cerevisiae to be essential for the G2/M transition of the cell cycle.	21.50	21.50	21.60	21.60	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.20	0.70	-5.23	6	52	2009-01-15 18:05:59	2005-09-28 14:11:52	5	2	26	0	25	47	0	225.70	33	97.19	CHANGED	Mh-slKshhssa.hh......csDGRK+EaGsLs-h+cRp..+sR+tpsppcucshh+hs+...............................sssptot.phtsphpt..................ssspcupt+shhssI+ulFSs-ppslptMppA...lshhL.s.otsppspcc...hpsRIlRS-sFKKKlhEhcYscphLppLR+Gupstp.sh.t.su.p......DpVlLLQ++lcch-c+ltplppELp.spKcLpFupEKspLLpsLLDDANIDscYlKSRRsIpNL.p.p-slpPp.csLs..PSPhR..sVNPLFTSSPlRpssppupcssspshp..........-NFYsKYP+lPcTEpLspptt..............ccSLSPlRlDYS+YSS	..............................................ts.sh.++pht.l...+ppp..p.t......pspphhph.+...............................c.t..pt......................................................................................................................................................................................................................Dp..L......phpt+httlcppLp........hpctLpaspEK.clLpslLDsuNID...pYhcSRRshpNl.p.p-p.....lKPh....sLs..P.SPhR.........tsNsLhTSSPh+h.shpsp....pshp...........sh..sthPp.P.pph.ppp................cco.........................................	0	3	10	17
+8370	PF08538	DUF1749		Protein of unknown function (DUF1749)	Mistry J, Wood V	anon	manual	Family	This is a plant and fungal family of unknown function.  This family contains many hypothetical proteins.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.96	0.70	-5.53	8	206	2012-10-03 11:45:05	2005-09-28 14:46:02	5	5	158	2	158	362	33	286.70	31	88.64	CHANGED	Muhphss......GlLHpYsp+L.......lAFEasosush..+sps....LlFlGGLGDGLhTVPYlpsLAsAL.......-tuuWSllplplSSSYuGWGTGSLcRDsEElppsV-Yl+sph....uG...sppKlVlMGHSTGSQDVlaYLopu.......................tspV-GuIlQAPVSDREAhhpshtc...........cthcchVshA+ch..lccGpuc-llPpEascthhh...soPlSAhRahSLsusc.....GDDDaFSSDLoDE.......cLscoFGplpc........PLLlLhSppDEaVPsal..DKpsLLsRW+pusc....cphWspp.SGIIsGAoHsVs....scupsts.chLlccVhuFL+	....................................................................................................t..............shla..a...t....t........ssaEat..sss...........t.p.s........llFlGGLs.DGhhos.sYhts....LupuL.................ptt..sWSlhplhL...oS...SapGa.......G....h.u....S...L..c...p.D.......s.c....El.sph.lp..Yl+sh........................s.p+lVLhGHSTGsQDllcYLp.pss......t........................p.sl.-.G...sI.LQAP..V.S.D.REuhthhhpt....................t.hpphlphAcph.....ls........p...u...p.s...pp..l.h.Phphsshhh...........................ssP.loAhRahSLsu.t........u-DDhFSSDL..s-..-.........pLpp.saGhlsp...................slLlLhS..spD-aV.Pthl..Dpp..t.L.lp+appsst..............t.hs......otll.s.....AsHslt....t..t......hhthl.tah.t........................................................................................................................	0	50	92	139
+8371	PF08539	HbrB		HbrB-like	Mistry J, Wood V	anon	manual	Domain	HbrB is involved hyphal growth and polarity [1].	22.00	22.00	22.10	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.39	28	284	2009-01-15 18:05:59	2005-09-28 16:01:24	6	8	167	0	164	267	1	140.30	32	25.68	CHANGED	pphosssAWshlpstllslF.........cucslp.hs..lEDLNclVphalppplppp.hss.....hlh...t-lcpLLssGhssLccpl.....pts.....s-+LlspLsElW.hFFsslLPhlQAlFLPlp.......htt.t.....tpstp.h...............................upELslRpLsLluFRDhllLshhpshthh	............................................................h..hsssssWs.lpstVlslF.........psc.sl...t...l..............sLNchl.c..h.hlppplssh.hsp...................hh........ppLLspGhhhLcc.pl..........................chh.................ps..pp.hl...sp...Ls-hWpaFFsplLPhlQAlFhPlp...............................................................................................................upp.slRplsLlsFRDhllLshh.t....t.....................................	0	36	68	110
+8372	PF08540	HMG_CoA_synt_C		Hydroxymethylglutaryl-coenzyme A synthase C terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	25.10	25.10	25.20	25.30	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.87	0.70	-4.93	10	2505	2012-10-02 12:25:54	2005-09-29 09:26:20	5	15	1386	46	503	1607	169	142.60	23	53.54	CHANGED	IVFDpulRuoHMpHAYDFYKP..DLsSEYPVVDGKLSlpCYLpALDpCYppYssK..hpphhtp..t.spthsLccFDahlFHoPaCKLVQKShARLlaNDFlppssp.phsslhccLpsh..tslch--oYpDR-lEKshhploKshaccKspPSLllsspsGNMYTuSLYuuLASLL.ptuss-LsG.KRluhFSYGSGLAAohFSh+lssDsssho..p..IsslhDlps+L.DsR+phoPE-FsEshclREpsHtpKsFsPpuS..l-sLhPGTaYLsplDchaRRsYup+	...............................................................hh........................................................................................................................................................................................................................................................................................................................................................................s....hsp..GNhYsuolahshhS.hl.........t........t......................s..pp.............lhhhSYGSG..uphat.h...l....t...................................................................................h..tth..............a................................................................................................................................................................................................................	1	143	271	402
+8373	PF08541	ACP_syn_III_C	ACP_C; 	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal  	Mistry J	anon	Pfam-B_67 (release 18.0)	Domain	This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.41, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.64	0.72	-3.97	187	7398	2012-10-02 12:25:54	2005-09-29 09:55:06	5	25	4322	91	2044	8046	1911	89.30	33	25.98	CHANGED	Lpps.slshsDlDhhlsHQANhRIlcs.hsc+Lsls..-..+shhsl.pcaGNTSAASlPlALscslcpG..clcsG-hlllsu.FGuGloWGusll+h	.........................................hppssls.h.p-..l....D..ah.l.s.H....Q............AN....h....R....I...l....c....s.....h.....s.....+.....+......L...........s.......l.......s........-.........+.s.....h...h...s.....l...p....caGN...TS...AAS...lP....lu....L...s.c....s....h....c....p.G........c.l..+..p.......G........c.......h........l.........l.lh...u..F.G.uG..hoaGusllc.......................................	1	605	1328	1740
+8374	PF08542	Rep_fac_C		Replication factor C C-terminal domain	Mistry J, Wood V, Finn RD, Coggill PC	anon	Pfam-B_930 (release 18.0)	Domain	This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA).  The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A [1].	21.00	21.00	21.00	21.00	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.59	0.72	-4.00	117	1565	2010-07-14 04:08:27	2005-09-29 17:21:44	6	38	497	21	1053	1492	176	89.50	21	25.10	CHANGED	shs..thlc.pllpphhp.p.....shtc..................spphlt.cLhsp...GhuspsIlpplhchlhph....sh..sph+hpllptluph-hRltpGssphlQLpuhlAph	................................................................................thlc.phlpthhs.t...............shpp...............................................s.tptlp.c.Lhsp...GhuspsIlp...p..lhchlhph............phs..sph+hcllctl.uph-hRlspGssphlQLtuhlup..................	0	361	595	866
+8375	PF08543	Phos_pyr_kin		Phosphomethylpyrimidine kinase	Mistry J, Wood V	anon	Pfam-B_787 (release 18.0)	Family	This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.55	0.70	-5.18	132	8058	2012-10-03 06:25:16	2005-09-30 10:04:10	7	34	4351	38	1754	12925	3225	233.80	27	80.50	CHANGED	DouGGAGIQADLKThpuhGsaGhosITulTAQN..TtGVpulpslss-.hlpsQl-ulhsDlslsAlKhGMLusscllcsV..Actl.cp.hsh.slVlDPVMlupoGspLlps-u.lpsl+cp..Ll.PhAsllTPNlsEAp.....hLsG....hplp...s.p..-hcpuAcplhp.h...GspsVLl..KGG.H.h..t............ppsh..DlLh....sssph.hthpstRlsTppTHGTGCThSuAIAAtLA+Ghsl.cAVppAKpalptAlp....pshplG..pG.tGPls	.............................................................................................................................Ds.uGuGh.ADltshtths..........sauhsslTsl.s.s.s.....s....t....s.....t..h........h.......p....h..l.tt..Qh...p...s..l...h...p.......s...h..........t........h.............c...A..l...K...h..G..h....L.u..s....s....c....h....l........c...h..l.....s....c.....h.....l......p...........p................p..........h...............l...V...l..D......P.......V.....M......s..s....p......s...........u...s........t.....l.....l..s....s.s.s....h...p....s...h....p.....p.....p.......L...l......P.h...A......s.....ll.TPNls.E.Ap...................hLsG.........hplp.........................s..c...........-h.h...p..A....u.......c....t..Lhs.....h..............G.s..p.....t....V..l..l....K..GG..c..h...t............................................pps.............-.hlh..............s.s.......p...p....h...........h......h..h..p..s.....s.....+......l......s...t.......p......p....s...+..G.TG.s.o.h.uu.....s.ls.u..........t..........L...s..........p.......G.....t...........s......l..t.....c....A.......l.p..p.A..p..t.a.ltpulp.......psh.p..h..s..............................................................................................	0	531	1053	1453
+8376	PF08544	GHMP_kinases_C		GHMP kinases C terminal 	Finn RD	anon	Prosite	Family	This family includes homoserine kinases, galactokinases and mevalonate kinases.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.76	0.72	-3.78	121	12811	2009-09-10 21:23:33	2005-09-30 10:45:27	8	48	4606	85	3000	8683	2225	82.10	18	24.10	CHANGED	hhpsl......t.............tpht.htphht..t...............hhthhhsplpplhcth.pphG......hssthoGu..Gsslhslh.............ppppsppltptl.ppthtp	..............................................................................h....h.t.............tphphh.up.hhp.ts..t......................h.hthth..splc.plhphs..tphG........shuuphoGu...GsslhuLs.................sp..pp.spplhptl.tt....t.......................................................	0	971	1843	2506
+8377	PF08545	ACP_syn_III		3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	Mistry J	anon	Pfam-B_135 (release 18.0)	Domain	This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.180, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.70	0.72	-4.32	170	6937	2012-10-02 12:25:54	2005-09-30 14:13:13	5	20	4279	91	1726	8497	1908	78.70	35	23.31	CHANGED	FDlsA.u...CoGFlauLshAsshlpuG.th+plLVlGu-thS+.hlDa...s...D..RsTsl....LFGD..GAGAsllpss......ppt.......u..lls...splto..DG	...................FDls.A.ACuGFlauLs.s.As.p.h...l...p.........o......G....t...........h..........+....p...s..LV.lG..u.-..p.h...S+....hl...Dh.......s.........................D.......Rs.Ts.l.....................L..F..GD...GAGAsllpss.......pp...............s...lls.hphts-G....................................................................	0	550	1116	1470
+8378	PF08546	ApbA_C		Ketopantoate reductase PanE/ApbA C terminal	Mistry J	anon	Pfam-B_396 (release 18.0)	Family	This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169.  The reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway [2].  ApbA and PanE are allelic [2].  ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway [1].	20.90	20.90	21.20	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.36	0.71	-4.13	112	4691	2009-01-15 18:05:59	2005-09-30 16:41:07	6	30	2834	28	1372	3635	1120	124.90	25	38.00	CHANGED	slttthWpKllhNs.....shNsloulhs...sss.uplh....tssthpplhptlhpEshtlu.........pupG...........................ht.hstp........................hhctlhphhpt..........sss.....p..psSMhpD.lppG+..oEl-hl.sGtllc.h.....ucphGls...sPhsphlhp.ll.+t.hp	.................................................slttthWpKlhhNs.................shNsloulhp...................ssh.uplh......................pp.s.t..h..pph...h.pplhpEsh.sVu...................pt.p.G.........................................................hp...hstp.........................................lhpt.lh.p.lhpt.............................sst........p.....hoSMhpD.lp.ptR....oElDhI.sGhllc.h.........uc..p.t..G...ls......s.Ph.sphlhphl+th........................................................................	0	379	802	1142
+8379	PF08547	CIA30		Complex I intermediate-associated protein 30 (CIA30)	Mistry J, Wood V	anon	manual	Family	This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits.\	 This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation [1][2].	19.70	19.00	19.80	19.00	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.90	0.71	-4.37	83	768	2012-10-03 19:46:52	2005-12-01 09:21:38	7	21	485	0	464	811	928	156.70	22	55.05	CHANGED	hcFsss......s...........shpp...WtslsDsVMG.GhSpuphph....................s.....ttuhFpGplShc..........ssGGFuShRo.........hps.hDlu..sasulpL+l+...GDG.+pYphplpsp..st............hsshsYptsFt.....T..sst...........Wpslc................lPascFhss.hRG+hlpst...s..h...sssplpplulhlu...........sc..psGsFpLpl	................................................................th.pp....WtshsDt.s.h.G...Gh.Spup.hphs...........................................s..stuhFpGplshc.............................................................ppu.Gasuh.Rs......................................hp..hc.h.s.sass..ltLcl+..............G..DG.......+..p...Yhlplpsp..s..............ts.ha.ptth.....st..sst....................Wpplp....................................................................lPaspFh..s...c..G.p........h.h...t............h...........p..plppluhhht..............st....G.atL.......................................................	1	145	272	386
+8380	PF08548	Peptidase_M10_C		Peptidase M10 serralysin C terminal	Mistry J, Rawlings ND	anon	Rawlings ND	Domain	Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs).\	\	\	\	The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain Pfam:PF00353.	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null --hand HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.11	0.71	-4.68	15	432	2009-01-15 18:05:59	2005-12-01 09:50:32	6	100	256	24	107	457	56	201.30	36	37.88	CHANGED	ANhoTRTGDTVYGFNSNT-RDFYoATSuSsKLIFSVWDAGGNDThDFSGaoQNQRINLNEuSFSDVGGLKGNVSIA+GVTIENAIGGSGNDlLIGNsAsNlLKGGAGNDIlYGGGGADpLWGGAGsDhFVYuuuuDSssuAsDhIpDFpSG.DKIDLSuhspsss....L+FV.DsFoGcAGEAlLoYDuuoslosLtlshuGcss.sDFlVplVGQsss.oDhIV	....................................................................................................................................................................................s.pTRssDTsY........GFN..S..s.....o...s...c......D....a.h....o..........u......s......s....s........s....s....p..l....l....F.olWD.uGGsD..ThD..FSGa.s.p...sptIsLs.......t...s...s..........a..........S.....s..........l...G..............G...............h...........t..........u.....N..........lo..........IAhs.sslE.NAlGGsGsDhlhGNtssN.l.Gss.........................................................................................................................................................................................................................................................................st..hhsststshhhhtt.tts.sts.Dhlh.DF..p...u...D.+l..sl..t....h...............h...hh....t.t...............h...t.........t........t...........................h.h............................................................................................................................................................................................................................................................................................................................................................................................................................	0	13	50	73
+8381	PF08549	SWI-SNF_Ssr4	DUF1750; SWI-SNF_ssr4; 	Fungal domain of unknown function (DUF1750)	Mistry J, Wood V	anon	manual	Domain	This is a fungal domain of unknown function.	19.50	19.50	19.50	19.50	19.00	19.20	hmmbuild  -o /dev/null HMM SEED	669	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.45	0.70	-6.22	3	99	2009-09-10 22:09:48	2005-12-01 10:49:12	5	3	82	0	83	100	0	503.50	32	94.93	CHANGED	MD.DPASRVPuQLLPHMHLVSRaRYPLMHMMPTDTVV-YLLSAPKIVREApPMHWTFLDGPQDGTVMLTWQPLNHLGTNFASDGYVWADVEQAFTFEA.RGYVVEMWLHRSGYHPPNESVAIHCRRRYRLLPoKVPNPSLPPPDPSLWIVHYSRAPPsDHIPANRIPVSPQVQsMLAQRRFLQsQGQLARKDFMLHDRNNWPTIsLPPQhA.sQuhtQPsGPYPNAMVGRQPFYPQPGssAsPPsusussKAPRGHRASoAAssAAosDFALEDE.DVSsGDLMDLLTPREVSKMRYQQHHEWMEEILASPYAISQITPVSLGLGRKGELESLTAGFFDAPVGPusGDSc-GsEusQATKLEPE+A-EFADRVAKKVADMTAEIEKLKKRHARRMEKFNRTStLKDAEpRLRDAAAsPtDTGSEIWRLEGRlEhsTE-DsucluPlEHKAKYKVDDIVREVEsSWpKpIVPEP+VSCVEKGGLLEKI...EPEPso.......................hhuDlDIDMGHTDSHLLDQF.TAtGssuQotuTsAP.....uAsGQAsPTATGVAssQPsA....GLDI-MDhGDupsouTAuGETGDWVMVN-s................KKDDslshPstph.tspTPGSGLQGLTPG.souuDsGLDusNFDFTN...MDSAGDALAAY.........TEQN-GLDLP.DLENSAFGDAFH..........ASDNEsTHHHDADDMS	.......................................................................................pas......h.hppshcaLhtAPpls+-.tPhhWta.lDt.P..DGolh.LsWQs..phGspFuoDGhhWsssE.hap.ph.pGh.....................lEhaht+sGahs....s.EphAhHsR+RaRLh..ss...s...s.......sDPsLa..llHYu.u...-plPssh.l.hs.th.....pth....httRp...h.L.ptGQ.lhRK-FMLpDRs....sWPpls...t....p........s......t...h..p.........h....s................................s.t............t......t..t.tps........s........h...............s..........-..h.s..........h.--E.-sSpG..DhhDhlTPR-lSh.RYpppHEWMEElhuSPYtltQI.PssLGLGh+GE.LtsLTtGhF.s....s....t..t....t.s......h.s.+hcst.sc-FtppstcphtthpsEhpphctpHtcthtphpp.shhhptEhtLR.hh......t.Gs-h.a+hE...s+hp....tpt.t..................p............l--lltplpttht+thss....tltplpcGGh.p.....t..P..........................................................s....DhsM..tst....t.hsth............t.......s.s...........................................s...................................................t.D.h...h...t...........s....p.................t..t....................s.....t....t......s......s-h.l....hlsp.t.............................................s.........s............................s.t..........s...h.st...................s..h..........-....hts......hsoAG-ALAsY...................tt.s.thsh..th.-sSAFG-AFH..........usptt............t..................................................	0	20	43	67
+8382	PF08550	DUF1752		Fungal protein of unknown function (DUF1752)	Mistry J, Wood V	anon	manual	Domain	This is a family of fungal proteins of unknown function. This short section domain is bounded by two highly conserved tryptophans. The family contains Swiss:P34072 that is thought to be a negative regulator of RAS-cAMP pathway in S.cerevisiae. the Sch.pombe member is a GAF1 transcription factor Swiss:Q10280 that is also associated with the zinc finger family GATA Pfam:PF00320.	20.90	20.90	20.90	20.90	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.69	0.72	-7.15	0.72	-4.36	48	460	2009-01-15 18:05:59	2005-12-01 11:05:33	5	14	156	0	340	467	0	29.00	39	4.13	CHANGED	lW+has+s+p.....plss..scRlENloWRhhstp	............W+hhspp+s.....plss..upRLENloWRhWsp......	0	88	185	291
+8383	PF08551	DUF1751		Eukaryotic integral membrane protein (DUF1751)	Mistry J, Wood V	anon	Pfam-B_13217 (release 18.0)	Domain	This domain is found in eukaryotic integral membrane proteins. Swiss:Q12239, a Saccharomyces cerervisiae protein, has been shown to localise COP II vesicles [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.38	0.72	-3.67	23	355	2012-10-01 23:21:32	2005-12-01 11:26:52	5	5	269	0	250	1107	281	98.30	29	27.91	CHANGED	Puhsh.....aPWoLlTusalEtslashllshlsLhluG+alEphWG.upEhlKFllllsshsNLlshlhtllhhhhops.p..L..h.lsGthulhsGhlVAhKQ	....................Pshhh.....as..W.ol..lTsshl..E.....p..s.....l..h.slllshhslhhsG+hLE.hWG..up..............Ehh+.Fl..h..llshh.ss.lls..hh...hh..l..lh..ah..h.......ots.p..........h....Lh..h.lpGh.huhhsGhLVAh+Q..................................................	1	73	135	210
+8384	PF08552	Kei1	DUF1753;	Inositolphosphorylceramide synthase subunit Kei1	Mistry J, Wood V	anon	manual	Family	Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase [2]. It is localised to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2 [2].  Kei1 is essential for both the activity and the Golgi localization of IPC synthase [2].	25.00	25.00	34.10	33.90	23.10	21.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.16	0.71	-4.63	17	133	2009-01-15 18:05:59	2005-12-01 11:35:41	6	5	128	0	100	134	0	176.00	31	63.88	CHANGED	poFLuhhsLhhGsEllhhhhlhNKsoGlYGlLulhTGasLshhQhhhYlaSlhsLshahhsl.pl+..c...........................psshpshhlshlYshDollsshaThhFshsWFht..........pstsssst............................sstsusstttsspsssu...htp..................................utstthEhhholhlslhhhllRhYFshllhuas...pplL+p.hhts	.....................pFhhhhsL.hGspllhhhhlhNKhoGlYGlLAlhT..Ga.Ls..hhQlshYlaSlhsLslhshhh.pI+...c.............................psshpsltlAalYhlDollsshaThhF.ussWFhh................tss......ssss.t..ts.....................................ss..tss.tssttstpstst..htp..................................ssshp.EphholhllsshhllRlYFshllhuFA...pplL+p.h...h...........	0	25	54	84
+8385	PF08553	VID27		VID27 cytoplasmic protein	Mistry J, Wood V	anon	manual	Family	This is a family of fungal and plant proteins and contains many hypothetical proteins.  VID27 is a cytoplasmic protein that plays a potential role in vacuolar protein degradation.	27.20	27.20	28.90	30.90	23.90	26.00	hmmbuild  -o /dev/null HMM SEED	794	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.72	0.70	-13.23	0.70	-6.31	9	256	2009-09-11 00:42:47	2005-12-01 11:45:52	5	5	188	0	187	259	0	563.90	30	87.52	CHANGED	M.hL+p....hhGsu.sppEllpIPuGpLYLlR..pSPKGspECIYpDAssoIR+Tu.-apYQLVVp+saEEGEsph.......tt.-s-Dsshs.........-DEhsFhlDcsLch+hphpctGctslsWcDlpGDpG.DhaEFVssss.lshspl-pFthTshcC.YEpKY++SspcAo-.--Lppacaps.hs............cscphsh--ph.ssshtphsss.scssps.s.htcutpp...t..............................ph.t..hhsttpu-LalYDshotpFlLQ..cssVslslh-sGc.acaWLtlcGt-p..Luhslss-hNPsFshpphSFlFNahssc.....shSWhL+FcDhsshscFppsaspslWEphNcpKWscs.csEpcYl.-Aaps.........hph-Dt.....ps..pE-E-E---E--spu.....ucpth-s-pa--ccsttt.pp...sssNppLAVGa+pDRSaVlRGsKIGVF+pss.sspLEFsTsIpplus.pGKhFsPcKhMLHtpD+phlLpDss.stspLY+MDLEhGKVV-EWcVpDcs...VssauPssKFAQMTsEQThlGlSpNulF+IDPRlSG.sKLV.-uphKpY.ASKNsFSuluTT-pGYlAVuSsKGDIRLFDRLGhNAKTtlPALG-PIlGlDVSADGRWlLATC+oYLLLlDshIK-G.KNtGpLGFp+SFst-uKPpP+RLplpPEHsAah.p.T.tcPlsFT.ApFNTGhsppEpoIVTSTGPYlloWShKclLpGc...psPYhIKRYsssVhADsF+FGoD+NVIVALccDVsMsp++shppPoRpslsss...........................shhNp.h	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.a....................sahl+F...s.........pF.tth.thha.t..t..ph.tp...p.p.Y.hhp.ht............................................................ht.pt..................pptttt..............p.tt.ttt.....................tpt.....p.p.p.......p........pp...t.........t............tthsp...p.LslGh..DpSallp..ss.t......ItV.a+p..........ps......t......l..p.....at........s.shs.plp.....s........pG...p.......h...s..PpKsh.....L.hp.t-pshlL.....s.t.....p......ss.....t.....l.....aphDlEhGKlVpEWch.p...c...c...hs...hhshssp.s...KhuQhs.s.p.p.TFlGlspNsla+hD.....sR.........l.....s.u......sp.....l...........l...t.s.........p....h............+.........p...Y...spps......s......Fs.sh.ATTtpGhlsVuSpcGcIRLa...............s.......+..............h...............u.....h..p......AKTtlP.u.LG.pPIhtlDVotDG+WlLuTscoYLlLlss.h...p.cs..csps.ph..GFp.pph.sts.ppstP+hLtLpPtcst.h...t...tps..l..pFs.ApF..s..T..t.....s...p....pE.ppIlsusG.ahlhWshcplhpup.....ptsYph.......................................................................................................................................................................................................	0	69	126	168
+8387	PF08555	DUF1754		Eukaryotic family of unknown function (DUF1754)	Daub J, Mistry J, Wood V	anon	Pfam-B_10536 (release 18.0)	Family	This is a eukaryotic protein family of unknown function.	21.70	21.70	21.70	21.90	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.32	0.72	-10.62	0.72	-3.40	37	249	2009-01-15 18:05:59	2005-12-02 16:25:23	5	7	201	0	171	240	1	86.70	28	58.97	CHANGED	c....Ysp.sssGpLKLKGst..h............+KKKKKccppspp....pctstpspppppppstcst.....................................tptt.pttsthshTcAE+pacchpcKRhpc	.......tYps.ss..tGpLKLKGss..h..............hh+KKKKK..c+ccpc.p......tpt.htssp.p.pp.ppp.pttt....................................................................thT.AEt...tacchpcKR........................................	0	56	89	131
+8389	PF08557	Lipid_DES		Sphingolipid Delta4-desaturase (DES)	Daub J, Mistry J, Wood V	anon	Pfam-B_9504 (release 18.0)	Domain	Sphingolipids are important membrane signalling molecules involved in many different cellular functions in eukaryotes. Sphingolipid delta 4-desaturase catalyses the formation of (E)-sphing-4-enine [1].  Some proteins in this family have bifunctional delta 4-desaturase/C-4-hydroxylase activity.  Delta 4-desaturated sphingolipids may play a role in early signalling required for entry into meiotic and spermatid differentiation pathways during Drosophila spermatogenesis [1].  This small domain associates with FA_desaturase Pfam:PF00487 and appears to be specific to sphingolipid delta 4-desaturase.	20.30	20.30	20.30	21.60	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.02	0.72	-4.71	24	352	2009-01-15 18:05:59	2005-12-05 16:10:50	5	5	268	0	247	355	8	37.80	47	11.04	CHANGED	sspsDFhWoho--PHssRR+tILpKa.PElKcLhGs-Pth	........csDF.WsYT-EP...HssRR+tILpKa.PEIKcLhGs-Ph......	0	89	133	203
+8390	PF08558	TRF		Telomere repeat binding factor (TRF)	Daub J, Wood V	anon	Pfam-B_8956 (release 18.0) 	Domain	Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain Pfam:PF00249 at the carboxy terminus [1]. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection [1]. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres [2]. This domain is composed of multiple alpha helices [3] arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors [4].	25.00	25.00	27.10	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.23	0.70	-11.43	0.70	-5.03	27	262	2009-01-15 18:05:59	2005-12-05 16:13:17	5	4	151	11	139	253	0	216.50	25	37.59	CHANGED	hhp..oL.shLDsl......................usQlLphltp....s...h...htp.ts....spspsFppltslFchhpcha.scsshl.s.pl..............hpsppthl.psl++sNhuphlssshss.c.luh...h.LsptFl-lFsspss......................................phh+spshLhlpLKTQAaIsulc..............tt.cppp-lLcclhssshps.h..hp.........l....sEhphh.+hcpR+cpLh....ppsshpsL.ppasatsFh+clhsalppphs.....hllhutptts.spt.ps	.......................s.......hL-.h......................shpllphhtp....................................spspsFpph.pslhctlhphh.......spss.........................hpt+phhlhph..Lp+ls.uph.L...sspF..sspp..ls....hEss.thhchhpsEts.................................................hh.csppplhh.lKpQAhlsshc.............................................ptphcptp-lLc.clFscs.sp......................................pph+ppLl..lp.pcsshcslhppas..apphhcclhsalppphs.....hLhhttpthhpp...stp.................................................	0	15	46	92
+8391	PF08559	Cut8_C	Cut8;	Cut8 six-helix bundle	Daub J, Wood V, Eberhardt R	anon	Wood V	Family	In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome [1]. Cut8 comprises three functional domains. An N-terminal lysine-rich segment (Pfam:PF14482) which binds to the proteasome when ubiquitinated, a central dimerisation domain (Pfam:PF14483) and a C-terminal six-helix bundle (this entry), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding [2]. Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8 [1]. Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome [1]. In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 [1]. Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum [1].	21.00	21.00	21.50	21.50	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.92	0.71	-4.36	19	160	2009-01-15 18:05:59	2005-12-05 16:15:06	5	5	156	3	123	156	0	140.60	30	43.46	CHANGED	PolpsslplLpphhpplhsslP..YspsspS......DYAYhRl+tpLhphLssLsDas.paLPP.....pcsphptSLpFLDtATpll+pLPsa-otpaNhhKspsY-plupsWhlllpcuucctsshth..s.....................pcLpc+NppSss+.hppsl	...............................PolpsslphLpphppplhpulP..hu.psspu..................DYAYsRl+.pLsphlc.sLsDas...phLPP.....pp..p.phssSLpaLct.A.Tcl.l+pLPpW-stpaNhh+cpsa-plupsW.hhlIcc.uucc.tuthphp.sth...................................ppLtcaNppusGc.hpps......................................................	0	30	60	103
+8392	PF08560	DUF1757		Protein of unknown function (DUF1757)	Bateman A	anon	Bateman A	Family	This family of proteins are about 150 amino acids in length and have no known function.	21.00	21.00	21.80	21.50	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.94	0.71	-4.53	4	53	2009-01-15 18:05:59	2005-12-13 12:59:48	5	4	28	0	49	49	0	149.10	24	75.66	CHANGED	pWF+NhhGhp...lo-pEhtsIPpPcsEhslHlTh+ohQAhuLlGullsuPlsphlpu.+.Nhpthpssusphu+hG........hlhGlVsuPhLsYhch+stshsp.uLaDRCYRLRhNpsplRhDRhuhlushsG..........hhpsuhhGhVsGssluhsYs.l.Sshhs	.............................................................lPpPthphslHssh+uhpsuull...............Gu.ll.sPl..hhh.hpp..pp....s..p.thh..s........shspsupsG........slsGhshGPh..lohhch+s..hschchhDRsYRLRhNpspLphDRhslhuuslG....................hh.ss.hGhVsGlsluhhhs........h.h.....................................	1	23	30	49
+8393	PF08561	Ribosomal_L37		Mitochondrial ribosomal protein L37	Bateman A	anon	Bateman A	Family	This family includes yeast MRPL37 a mitochondrial ribosomal protein [1].	19.60	19.60	22.90	20.20	17.50	17.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.76	0.72	-4.41	23	304	2009-01-15 18:05:59	2005-12-13 13:51:40	5	2	258	0	232	295	1	89.50	29	61.01	CHANGED	spsssSus.suThlsslNlhKs.GpDPshL.DSEYP-WLWpl.LDssspstcttcss.............................................................................p.t++hhRptp+ppI+psNhLsph	....................................s....hsss.hsThltGlNhhKs.spDshhh.DsEYP-WL....Wpl...hss.t....thtcttcss...................................................................................htth+chhRttp+pp.I+psNhLpt..................................................................................	1	75	126	188
+8394	PF08562	Crisp		Crisp	Mistry J	anon	manual	Domain	This domain is found on Crisp proteins which contain Pfam:PF00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling [1]. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK [1].	20.10	20.10	23.10	29.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.85	0.72	-3.69	26	238	2012-10-02 17:51:16	2006-01-03 16:31:09	5	2	114	25	72	235	0	54.30	49	22.83	CHANGED	CuDCPssC-NGLCTNsCpapDtaoNCsoLtpphuCpp.phlKspC.AoChCcscIh	CusCPssC.-.s...G.LCTNPCpapDtaoNCcsLtp...p...h...uCpc.....ph.....l.....+ppCtAoChCpscIh....	0	7	10	37
+8395	PF08563	P53_TAD		P53 transactivation motif	Finn RD	anon	Pfam-B_3515 (release 19.0)	Motif	The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation.  This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence [1-2].	20.00	20.00	20.00	22.30	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.69	0.72	-7.08	0.72	-4.85	12	143	2009-01-15 18:05:59	2006-01-03 16:48:47	6	6	66	16	32	159	0	24.40	62	6.48	CHANGED	spptshs.PLSQ-TFp-LWphLsts	.....S-.ulEPPLSQETFSDLW+LLPEs....	0	3	4	6
+8396	PF08564	CDC37_C	Cdc37;	Cdc37 C terminal domain	Bateman A, Mistry J, Wood V	anon	Pfam-B_3345 (release 6.5)	Domain	Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the C terminal domain whose function is unclear.  It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain Pfam:PF08565 and the N terminal kinase binding domain of Cdc37 Pfam:PF03234 [2].	20.80	20.80	21.00	22.10	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.30	0.72	-4.16	31	299	2009-09-11 10:45:19	2006-01-04 11:51:26	5	10	236	1	188	289	3	91.80	29	21.44	CHANGED	h.h..Ps...............uhDP...........clF-.oLPs-hQcsh-occl-tlpcslucMss-EActhhcphs-uGlhs.puth.......sptphc-.ptp.....tthpptptppttsp	......................hPu...uhDP...........-lF-.oLPt-hQcsh-opsl-hlpcslucMss--Achhhc+hs-uGlhs.psth.................psppphp-.ttt.....................stts.............................	1	59	99	155
+8397	PF08565	CDC37_M	Cdc37;	Cdc37 Hsp90 binding domain	Bateman A, Mistry J, Wood V	anon	Pfam-B_3345 (release 6.5)	Domain	Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37 [2].  It is found between the N terminal Cdc37 domain Pfam:PF03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 Pfam:PF08564 whose function is unclear.	25.00	25.00	26.30	25.10	22.80	24.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.05	0.71	-4.78	19	361	2009-01-15 18:05:59	2006-01-04 12:01:11	6	12	244	3	220	346	3	181.10	27	44.13	CHANGED	NKsptt........t.st.ts.pphpphsppsEpl...................................ccFuplp.scaccoppFLh-HspllsEpptctLlhpAFchphctccchhpplsHQullhQYlhp...Lu+..phss...+sslp.FFpKlts..sc..htptFpc-Vpshhp+l+sRupth....hcEpppps	.................................................................................................................................................pt.tt.........................tt..tp.ph.s.....................................................t..p...............p.ht........h.+....cFGhlp..cac-SpcFLp-H.s.p.L.l.s..E.c..s..ss.hLllhshchph....E.p..............Kp.s....hhcplsHQsllhQalh-....L.ucp.phss.......Rsslp.FFpK....lps...sct.hhcsFps-lpshhpR.l+tRAp.h.......hp-.t...t........................	0	65	105	170
+8398	PF08566	Pam17		Mitochondrial import protein Pam17	Mistry J, Wood V	anon	manual	Family	The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix.  The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase [1]. Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins [1].	20.50	20.50	21.30	47.60	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.97	0.71	-4.57	24	137	2012-10-02 17:14:55	2006-01-05 11:20:55	5	2	133	0	108	136	0	173.70	40	77.72	CHANGED	hsp........sshpssSssssssssss..............LsWssFFpLR+p...cRRhshsoSlhTulsusshuhsaLushplD.....sp.IhGlDPhhllGhushusuulGaLhGPhlGsslFpLhp....RpthtthphK-p-FhpRI++pRVDPSupShuNPVPDYYGEKIuSlpsYRQWLRDppAapRKsc.pF....l	............................thtstts.........putst..ssstttss.............LsWssFFpLR+p...+RRhslsuSlhsulhu...sssussh....Lu...sh..phD.......st.lhGhDPhhllGhushusuulGaLlGPh.lGsslapLhp....R.phhsthsh......K-+EFapRI++pRVD..P..S.upShuNP..VPDYYGEKIuSlpsYRQWL+DQ.+AasRKtppFl.................	0	34	62	93
+8399	PF08567	TFIIH_BTF_p62_N		TFIIH p62 subunit, N-terminal domain	Finn RD	anon	Pfam-B_31040 (release 19.0)	Domain	The N-terminal domain of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity.  The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal domain reveals that it adopts a pleckstrin homology (PH) fold [1,2].	21.10	21.10	21.20	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.35	0.72	-4.33	19	254	2009-01-15 18:05:59	2006-01-05 11:46:22	6	6	219	7	178	238	0	74.10	34	13.13	CHANGED	h.hpGtssaK.....Kss......GhLplspDpp.ltWhspussusp.sloltlspIssLQtoPtsusKlhL+llh+ss.......pshphhFss	.........h...stpspaK.....Kp-......GsLhlhs-+..lsWssc......upcpss....lohhhucIps..........phoPcu.psKl.Lpllh+ss.........sspsahF.....................	0	52	87	143
+8400	PF08568	Kinetochor_Ybp2	DUF1760; 	Uncharacterised protein family, YAP/Alf4/glomulin	Mistry J, Wood V, Lonsdale D	anon	manual	Family	This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS) [1,2]. The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation [3] [14731255]. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12 [4,5].	21.40	21.40	21.60	22.10	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.13	0.70	-13.07	0.70	-6.28	29	316	2009-12-17 14:51:14	2006-01-05 11:55:57	5	8	213	0	210	288	0	458.30	17	85.82	CHANGED	M.............................................................htct.s......shhpt...spDhloalThl-hh..................p.p.thLstLhplL.p.-..pslsppIGWDLsphLl.hlstsp.................cChpplAchGNP+EllLpssEhLppLps....................................tDps..pp...................................ttp.t..hpl.ph.s...LlphlsshhpRIpTphPS+FLuhulpulhphhpp.s.....ppshs.hpFl.....+plhshpRsh.sst.sp.................ss-hsscs.s.hhssEssl.++lLpthhhphlpphlh..........shphshch.....sth...h.sttpppphhs.pp.ht.h..lhu+hstLu.....hDlsLps.h....h............ppl.....t.s.pspsh....s...-cs.hphc..h.h............cIslshpGsLlLhstthh.............pssp.........hsDhlhlhlchs........sshhpspulpDshhhhshhshpssp...........t.h....spthhhsalpsLhhhsspps...th+ttshplhsplLphtPpps.pachI+csLcsssat....slKsshluhLKc.lhpsppssptt.....................................................ptslhlsscphsslhsllhtshpthh..............hhp...p.hshlhuhLNlhhhlhp.........p.s..............hhhpchhcslcshlpthcschttp....................................stpph.ph....ssp.hLpps	......................................................................................................................................................................................................................................................................................t......t-...h...h.h.......................thh..l.phl.p..p.....hhtphGWsL.t.ll.h..h..pp...................thhp.lst..ssP+EhllthhEhltp.p........................................................................................................t..h.h........Lhp.lthhh.+l..t..shhstp.lt.hslpslhp.ht..s.......tt.t.........hh...............ptl.t..hps.....................................................................p...p....t...........t..-.....tp.l..hhh..lt..h....................................................................h.ht.h.th.......s..h...............................................p......t.....................th.....s.hhh.h.................................hh.hh.phh...........t........sh.......h..hhh...tp............................t................hh..thhphlhhhhhhp......s....th...Rph.sh..tlhphhlphhsp.ps.+aphhtph.lp.ss..h.....shps.hlthlKp.h..s.tts...........................................................hh.hss.th.tlh.hhh....pt..........................p...t...s.h....lhsh...LNh.hhhLh...................................p.p....................t.........th.pphhp.lp.hhp...tph...............................................................t..............................................................................................................	0	53	106	167
+8401	PF08569	Mo25		Mo25-like	Finn RD	anon	Pfam-B_5502 (release 18.0)	Family	Mo25-like proteins are involved in both polarised growth and cytokinesis.  In fission yeast Mo25 is localised alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner [1,2].	20.50	20.50	20.50	22.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.89	0.70	-5.41	23	518	2012-10-11 20:01:01	2006-01-05 12:11:16	6	8	288	6	335	448	8	289.20	41	92.36	CHANGED	MsFhF...p+.sp.KoPs-lV+slp-tlhtLt..............tscstcKs.-EluKpLsshKphlhGss-s-PssEp...lspLspEhhpp.-llh.LlpsLtpL-FE.uRKDlshlasplLRpphss...........ps.Ps......V-Ylspp.sclLshLlcuY-.......ss-luLssGshLREsl............................+a-sls+llLh...ss.......................pFap.....FFcalphssF-IuoDuasTh+-LLTpH+plVucaL...psNa-cFhs.phspLlpSsNYVT+RQSlKLLu-llL-RsNhplMspYlsss-NLKLhMpLLpDcS+NlQhEAFHlFKVFVANPsKspPlhcILl+N+-KLlcFLpsFpsD+h.cDcpFhDEKpall+pIppL.p	.................................................................................F...tp...p...+sPs-lV+th+-.l.h.L....................................................ts.pptpct.--luKpL.thKtlLhGs..................s..........-t...-.....P.s-t................lsQLspEhh.pp..slLhh..Llt..sL.hlsFE......u+K..DssplFspllRp..phss.......................c..ss.......l-Yl......sp..cll.hLhpGY-...............s.-....hALpsG.hLREsl...............................+a.-slA+.hlL....sp..............................................................pFhp.....FF.c.a.lp.....hssF-lAoDAF...sTF+................-LLT.+..........HK.........lsucaL...............ppNa-h.FFp...h...p.pLl.pS....p.N.YV..T+RQSlKLLGElLLDRpNhslMs+Ylsps-NLKlhMsLL+..D.cS+s.IQhEA..FHVFK.....VFVAN..P......pKs.s.lhpILlpNppKLlcFLtpF..........tt-+..........-D-QFt-E..Kthll+pIppL........................................	0	107	186	274
+8402	PF08570	DUF1761		Protein of unknown function (DUF1761)	Wood V, Finn RD, Bateman A	anon	Pfam-B_85869 (release 19.0)	Family	Family of conserved fungal and bacterial membrane proteins with unknown function.	26.00	26.00	26.30	26.80	25.20	25.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.71	0.71	-4.12	81	254	2009-01-15 18:05:59	2006-01-05 13:12:42	5	3	233	0	120	231	54	127.80	21	85.78	CHANGED	hlAlllAslsuallGslWYush..FGcsW...............hcstuhspcp..hcstts......shshshlsshlhuhhluhhhshhs.................................htohtsuhhhuhhlhls....hhsshhssshhapt+shplh..hIsuGatllsh................slhuhllsh	..........................................ulhluslhsahhuhhaassl..Fucsa...............hcutuhsspc......h+ptphh......shshshlsshltuhslutl.lsths.................................shohtsuhhhGhl....lhhu....h.ssthhsphha.....E..pRshp..hh..hlsuuapllth................lhlulhls.........	0	51	81	104
+8403	PF08571	Yos1		Yos1-like	Wood V, Finn RD	anon	Pfam-B_23321 (release 19.0)	Family	In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Yos1 appears to be conserved in eukaryotes[1].	19.30	19.30	20.60	20.00	18.60	17.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.59	0.72	-3.88	20	281	2009-01-15 18:05:59	2006-01-05 13:31:28	5	6	222	0	190	258	3	76.20	43	59.59	CHANGED	lhsLl.ulLLhlNAlAILsE-RFLu+lGW.usossps.u...............................sssolKspllsLIpuVRTlMRlPLIslNlllIlacLlLG	..................................................LhsLlpusLLhlNAlAlLsE............-............RFLs+.lGW..ut.sp.s.t.s..G..........................t..............ppsolKupllsLItulRTlhR..........l..........P.LIhlNhlhIlhtLlhG............................	0	51	99	153
+8404	PF08572	PRP3		pre-mRNA processing factor 3 (PRP3)	Mistry J, Wood V	anon	Pfam-B_7232 (release 18.0)	Domain	Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor.  The human PRP3 has been implicated in autosomal retinitis pigmentosa [2].	31.40	31.40	36.40	33.40	21.70	28.30	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.55	0.70	-4.97	21	355	2009-01-15 18:05:59	2006-01-05 13:48:31	5	10	293	0	250	343	1	212.70	39	38.51	CHANGED	ssPYhsspht..............tphpp+ppcshpFhctG+a.ppApchRpcsphE......chcpchtpt...scpsslpppp............tcph.ttphs.......................PslEWWDtshlsps..........shsslss-ts....t...........................p.ssIst....alpHPlslcsPh-...h.sss...slaLTKKEpKKlRRppRttppcE+p-+......I+LGLcPsP................PKVKlSNLM+VLss-A.lpDPTphEtcVRcphtERpppH.ccNppRKLTs	.................................................................................................................tsahDsphs..............htsttRpp+shpF.pppGKa.p.A.pph...RppsplE...................chptclspt...........s+c.s.Glppst...........................ths.hs.h.t.p.h..................................................................P.p.l.EWWDphllst.............................shpsl.sp..t..p..h...p............................................................................................p.psIT......hlpHPs.lpPP.t-.......hss...hshaLTpKEpKKlRRQp..Rttt.KEpQ-K.......IRLGL.PsP.............................PK.V+lSNLMRVLGs-A..VpDPTtlEs+V+pphAcRpptHpctNttRKLT.........................	0	87	141	208
+8405	PF08573	SAE2		DNA repair protein endonuclease SAE2/CtIP C-terminus	Mistry J, Wood V	anon	manual	Family	SAE2 is a protein involved in repairing meiotic and mitotic double-strand breaks in DNA.  It has been shown to negatively regulate DNA damage checkpoint signalling [1][2]. SAE2 is homologous to the CtIP proteins in mammals and an homologous protein in plants. Crucial sequence motifs that are highly conserved are the CxxC and the RHR motifs in this C-terminal part of the protein [3]. It is now known to be an endonuclease. In budding yeast, genetic evidence suggests that the SAE2 protein is essential for the processing of hairpin DNA intermediates and meiotic double-strand breaks by Mre11/Rad50 complexes. SAE2 binds DNA and exhibits endonuclease activity on single-stranded DNA independently of Mre11/Rad50 complexes, but hairpin DNA structures are cleaved cooperatively in the presence of Mre11/Rad50 or Mre11/Rad50/Xrs2.  Hairpin structures are not processed at the tip by SAE2 but rather at single-stranded DNA regions adjacent to the hairpin. The catalytic activities of SAE2 are important for its biological functions [6].	22.90	22.90	23.00	22.90	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.37	0.72	-3.28	22	209	2009-01-15 18:05:59	2006-01-05 14:38:56	5	9	190	0	153	218	1	83.20	35	12.52	CHANGED	sas-VlRp+c-Rcpl.pGs.p.sC..Csptapshut.t................................phh.lsphppcc+pchh.ptp........tp.hhpphu+HRapa.t+ssTPPGFWchDF.Ps	.............................................................EVVRcKp-RcpL..Gp...pC..Ctthatshs............................................t..tc.ccp..c..hh.................sphSRHRapa..h.ssTP.sFWcssF.Ps..............................	0	45	78	122
+8406	PF08574	DUF1762		Protein of unknown function (DUF1762)	Mistry J, Wood V	anon	manual	Family	This is a family of proteins of unknown function.\	\	\	    Swiss:Q07532 is known to interact with RNA polymerase II and deletion of this protein results in hypersensitivity to the K1 killer toxin [1].	21.30	21.30	21.50	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.88	0.72	-3.56	16	232	2009-01-15 18:05:59	2006-01-05 14:41:35	5	4	208	0	167	219	1	74.30	30	20.15	CHANGED	-sss-YVYDlYh.........hpps.--.pssp.s..........ppsIGalplh-csp-....hhp-----s....phhoDDEDSNsENaYpNDYP-DE	.........................................ps-YVYDlYh...........................tp....th.....................pslsh..l.hhhpp.....p.p..p...........hhs---..sc........h.pD--DSN.........sEs.apNDYP---..........	0	48	87	138
+8408	PF08576	DUF1764		Eukaryotic protein of unknown function (DUF1764)	Mistry J, Wood V	anon	manual	Family	This is a family of eukaryotic proteins of unknown function. This family contains many hypothetical proteins.	21.80	21.80	24.20	22.20	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-11.11	0.72	-3.24	19	96	2009-01-15 18:05:59	2006-01-05 15:47:32	5	1	85	0	71	96	3	111.90	24	68.96	CHANGED	pscK..............tstphslsshFsstptpppctp..t.........pspcspssp................ttp.p.phppsttRRcs.DGhhIaoh....EELp...hu..cu.GsTs..........pCPFDC-CCF	.......................................................................................................................ttp.............t.tp.ttpl-plFsshpppppptptttpt.....................p.pt.t.pp..................ppppptpspp.tttp.....s..ps..sp...sRR+TpDGhsIYot....-ELs...hu.....p.u.GsTs...............CPFDCpCCF.........	0	41	56	66
+8409	PF08577	PI31_Prot_C	PI31_Prot_Reg;	PI31 proteasome regulator 	Wood V, Finn RD	anon	Manual	Family	PI31 is a cellular regulator of proteasome formation and of proteasome-mediated antigen processing [1].	25.00	25.00	25.00	25.00	22.50	24.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.11	0.72	-3.33	26	230	2009-01-15 18:05:59	2006-01-05 15:52:27	6	3	199	0	156	220	0	74.20	35	24.24	CHANGED	shGcsDL.P.................sGhs..sshps.hss....................t........GGMh.sss...c.PhFss.tp...stt...s...........ssssPPGARa.DPhGP	....................................hGppDL.P..................Ghs.........sshpsh..hss..s.......................stt.........GGMhssPp...c.shFsp..h..........ssp.......G.s.........tth.ssusPPGARa.DP.hGP....	0	50	82	126
+8410	PF08578	DUF1765		Protein of unknown function (DUF1765)	Wood V, Finn RD	anon	Manual	Family	This region represents a conserved region found in hypothetical proteins from fungi, mycetozoa and entamoebidae.	25.00	25.00	25.00	32.40	22.80	24.50	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.56	0.71	-4.07	31	180	2009-09-10 15:38:14	2006-01-05 15:55:44	5	6	133	0	142	183	0	130.40	24	11.91	CHANGED	hhstllhshsp+TslYDtssshhlhshlpphl.thhst...p..........................h.shhDapFWLpslthhlp.ocpsho.h+slthlassWshhshs.c+cl.....................................lc..aLlppphah+hF.HWs.hVRshFh+LLlaRlh	...............................h.hsthlphhhp+TslaDtsushhlh-hlcchl..hhsphppp......................................hsshhDasFalsshchhlp.ocsshs.l+slsalassWshl..sts.ccch....................................hhc.hLLspphF.c.h.F..HWsshVRshah+LLsaRl.................................................................	0	62	94	129
+8411	PF08579	RPM2		Mitochondrial ribonuclease P subunit (RPM2)	Mistry J, Wood V	anon	manual	Family	Ribonuclease P (RNase P) generates mature tRNA molecules by cleaving their 5' ends.  RPM2 is a protein subunit of the yeast mitochondrial RNase P.  It has the ability to act as transcriptional activator in the nucleus where it plays a role in defining the steady-state levels of mRNAs for some nucleus-encoded mitochondrial components [2].	27.00	27.00	27.00	27.50	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.63	0.71	-3.97	6	46	2009-01-15 18:05:59	2006-01-05 16:12:12	6	4	43	0	28	49	0	122.10	36	10.25	CHANGED	slht--sh.sWp...pDpEssLN....cpsaLpTpIcpIpssacp....csYNhINsLYQoLKRNsI.lPslclaspVLpSIscRcLDs.....ssI-sKhhpLLoCYQDIlsN+...lKPspEIYsIVlsoLL+GSlp	.........................t..........hp...p-s-ssl.....cpsaLpTp.lspIspsapp....pchNhI.sLYQuLKRNsl.lPsl-lYshVLcSlscRplDs.....ssl-sKlspLLTsYQDl.l...ssp.......lKPscEhYNIVltuLhcGSl...	0	3	14	27
+8412	PF08580	KAR9		Yeast cortical protein KAR9	Mistry J, Wood V	anon	manual	Family	The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules [1]. KAR9 localises at the shmoo tip in mating cells and at the tip of the growing bud in anaphase [1].	20.40	20.40	23.20	21.80	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	683	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-13.22	0.70	-6.25	9	136	2009-01-15 18:05:59	2006-01-05 16:19:49	5	3	119	0	96	131	0	566.70	25	69.82	CHANGED	p.ppclsplspllhsphs.l.t.....l.phhsstcshhsslhphh....-Wlh-u+sllhpL.............hpslcsI-psls+hhphl-s.hts.ps.p.pc-.hs..hhslh-csoplhs......pl+shlpslKchlDhAlEapEIhcshhssLspEl-pshphsh-lpEc+atSPh....+c.hssFsL-pllcph......usp.ssp....phph.PsF..............ss.-cplhpcalpL.csplsPlcsSL.-hLP.RlspFpsRs......p.hsshtp.Lpc+apsLhccYchLpsEhppL+pEll-c+WshlFpsLscElthhh-.sl.+.lp+lpss.ph..shphp.t.thscplpshptphp+ohslIhpAhp.S..Ilscu.lushhN..........chts+W.pL.........+...phh-plLpc.psps..t..............ss.spshpohop.....s.sspsl.sssspt......sspsSpp.shss.ptt+hussL.c+hshtPs.sp..s.t............................ssssssshhps..............psPhFs................ps....cp......t.................................s..t.............sphs..S.p+..hthshoplPslu.pps.hhps............................shpRsssptSp.....h.phtspl........s.s.............................sh.+Sltp..ttpht..tp.h.ssphPsh.hpt..s......psshlspstth.phsts.....sp.cct.....l+.P	................................hspplsplopl.hs....ltt.h.....lssh.ssh+.sh.s..sst.ph.....tWh.cupphltsL.............hcsl.cpl-puls+h.pLlps.htt.-php.+.-hsp.s..s.lhp.s.sphct......pl+thLpslKppl-lAhEapElhssllsslt.Eh-ph.phhhEhcEcRato.h..........tp.hsh.pLEpllcph.........................t.....t..tsp...................ph.ph...Phh...................st--p...phLsL.hu+hpPLcsSL.-hLP.hRls.FpsRs.....pphFsoup...ccLpp+ppt...L.ppa+tLpp-tcsL..+cELh-cRWsllFRshscpspphh-.ulE+sl.....tK....lpp..........s...p.........thphpt.......thscclcshpt....pps+hhssI..thhhu..llpcG.lts+hs.........t-htt+atsl.................p......t.hDth.L....pchpspp..............+c...slsp.ho...tps...tp.sh.tTsss.......sssS.pl.hhss.........hs..........t.......................p.....t.ps..p..s..s.s.......tt.pphsts..p+.s..hPt..s.s..ttp...........t........................................t.....t..............................t.p.s.hp........t.......t................................................................................h.............p..........s..hs......................p........................................................p......s..............t.ph..................s.s..h........................................................p.th..............................s......................t....................................th...................................................................................................................................................................................................	0	22	51	84
+8413	PF08581	Tup_N		Tup N-terminal	Wood V, Finn RD	anon	Pfam-B_9595 (release 19.0)	Domain	The N-terminal domain of the Tup protein has been shown to interact with the Ssn6 transcriptional co-repressor [1].	22.40	22.40	22.40	22.70	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.67	0.72	-3.79	20	172	2009-01-15 18:05:59	2006-01-06 11:04:59	5	8	149	6	122	173	2	74.50	42	12.30	CHANGED	RLsELLDulRpEF-shupcst.hp..ppc-YEt+..lspQlpEhphIRpoVY-LEtsHpKhKppYE-EIt+L+pELEsRstp	....................RLsELLDtlRpEF-s.sp........ppc-aEpp..lspQlpEMphIRppVYpLEpsahKhKppY...E-EIppL+pcLEsRsh............	0	40	73	109
+8415	PF08583	Cmc1	UPF0287; 	Cytochrome c oxidase biogenesis protein Cmc1 like	Mistry J, Wood V	anon	manual	Family	Cmc1 is a metallo-chaperone like protein which is known to localise to the inner mitochondrial membrane in Saccharomyces cerevisiae.  It is essential for full expression of cytochrome c oxidase and respiration [1].  Cmc1 contains two Cx9C motifs and is able to bind copper(I).  Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.82	0.72	-4.20	52	511	2012-10-02 15:44:21	2006-01-06 11:43:59	5	6	275	0	351	549	2	68.80	21	58.80	CHANGED	h+pthcpcsh.cpCpchlpsht-Cppp..phhpshhtCpcpppthppClpphppscth........ctpcschhpc.+hc	..................hh..hpp+tp.ppCsphlp............thpcCpps......p....hh..phhst.CpctppthppCLpttttppth....................pttctchhpp.+...................................	0	101	180	284
+8416	PF08584	Ribonuc_P_40		Ribonuclease P 40kDa (Rpp40) subunit	Wood V, Finn RD	anon	Manual	Family	The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex [1].	20.20	20.20	20.70	20.50	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.65	0.70	-5.40	15	216	2009-01-15 18:05:59	2006-01-06 12:26:07	6	3	179	0	151	218	0	217.90	26	71.17	CHANGED	LppLL-.....s-FhsoaIKp...........................GshhhlS.csR.ssDNshsLhs...GpLhLpLsK-sYEcsGLpGKPschuG++th..RalVclDL+.sShthGpKuFpRlhWuhKshLs.hsssaLahphsos..uhsp.tpssshLssa...........psplhpscssppphpslhsPsLspschsspspstt.hp-......up-LhEWLGhVuls...lsssD.cs-saLSpYssP.-sssth...schlslpWpGFlsPphlhpLltslp+hh.......................ts.s.ssWhuLospGFucsslp...........GcssYTllhhssp	....................................................................hlp.tFhpthlp..............................G.phhhlo..ps.....p.s.....ssshs.lhs...GhLhLpLsK-sYEph.G.L.G+......s.........t..t......s....cc....................+a.llplsL...h......sh....sp.+ta.pRl.huhcphhs.....t.....h.....shLht.h.ss..................s.h.tth....................................................t.p.hp...p.thp...htp.l....h........P....h.t............t.t.t..................pp.......................s.-hh-WLuhs..t.......lph...ss.p.ssalSpYp.sP......pssp.h.............sphhhh.....phpG......hl.sphl..lh.t..hhp.h..........................t.....Whs.lsspuhscsslt.........................................................................................................................................................	0	51	78	117
+8417	PF08585	DUF1767		Domain of unknown function (DUF1767)	Wood V, Finn RD	anon	Manual	Domain	Eukaryotic domain of unknown function.  This domain is found to the N-terminus of the nucleic acid binding domain.	20.40	20.40	20.40	20.60	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.18	0.72	-3.71	34	333	2009-01-15 18:05:59	2006-01-06 14:33:46	7	14	209	1	245	330	0	87.50	23	16.57	CHANGED	sphLppht..ltlsspWLpphlst............s.sthspplhpphLssDl+-h..s...tssLPs..sltp..hpptpLp...........GshlLQlpplp-Iotshh.sphp	.............................................htpht..h.l.s..p.alpthhs............................s.sthspplhpphLtsDLcsh......s........tss..LPs...sltp.......hpptpLs.......................GshlL....Qlppltslutsth.pp.................	0	80	130	199
+8418	PF08586	Rsc14		RSC complex, Rsc14/Ldb7 subunit	Wood V, Finn RD	anon	Manual	Family	RSC is an ATP-dependent chromatin remodelling complex found in yeast. The RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions [1].	25.00	25.00	89.30	84.80	19.60	18.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.28	0.72	-3.53	5	27	2009-09-10 21:44:18	2006-01-06 14:54:42	5	1	26	0	15	19	0	100.30	60	53.69	CHANGED	huYYDVIuGLSuLE+ScpVoFospELpELT....cps--sRcsp-..ELp+s-pEcsKRVsVHGYLGG+Vuh+-AupAs.....Y-LsHTLLGGYVPRpQLESLSSsDFA	.hGYYDVlAGLSALEKSsQVsFSssELQQLT.....QQscsscKuh-ssE..so+ucsoKsKRVsVHGYLGGKVoLuDAupsp.....Y-luHoLLGuYVPRpQLEuLSSlDFu	0	1	6	12
+8419	PF08587	UBA_2		Ubiquitin associated domain (UBA) 	Mistry J, Wood V	anon	Pfam-B_10238 (Release 18.0)	Domain	This is a UBA (ubiquitin associated) domain [1].  Ubiquitin is involved in intracellular proteolysis.	21.80	21.80	22.10	22.70	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.11	0.72	-3.77	7	138	2012-10-01 23:03:33	2006-01-06 15:47:57	6	5	132	2	94	130	0	44.70	45	6.48	CHANGED	lD-sllptLSpTMGYs+D.-Ih-uLcp............sEs....NEI+DAYhLl+EN	.....lccpllscLu+TM.GYs+-.-I.-ALcp............sEP......stIKDAYhll+EN..	0	17	47	79
+8420	PF08588	DUF1769		Protein of unknown function (DUF1769)	Wood V, Finn RD	anon	Manual	Family	Family of fungal protein with unknown function.	21.10	21.10	21.20	21.80	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.51	0.72	-4.02	16	120	2009-01-15 18:05:59	2006-01-06 16:05:57	5	4	103	0	99	124	0	55.50	48	14.49	CHANGED	Gs-LlFGNDF-+PI+chlPsu.hssuh+lhp.aIDPslcGDlYuDc..PYLYuPuLuSh	.....GsDLlFGNDFD+PIRDpLPsG.hssAh+ls+WaIDPuL-GDsY.AD+..PYLYuPuLuSa................	0	34	60	86
+8421	PF08589	DUF1770		Fungal protein of unknown function (DUF1770)	Wood V, Bateman A	anon	Wood V	Family	The function of this family is unknown. These proteins are rather dissimilar except for a single strongly conserved motif (PDLRFEQ).	25.00	25.00	26.20	32.40	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.66	0.72	-3.40	12	76	2009-01-15 18:05:59	2006-01-06 16:12:56	5	1	75	0	61	73	0	97.40	42	56.10	CHANGED	ApTlQTAols+.c..............................PSPp+..................DlNssT............uAsc+p...sls...pps.s-.sDSls...........p-.s-....spp......hlpPhsRR..p.........phPPlPDLRFEQ......SYLsSIcuA-.o........................WtcVAaIT	......................................ApTlQoApIp..p..............................PSstH..................DlNPsT............AAsc+p........Plsh...t.....ps-...s-uls.................sDh.-....Ppp.........sl+.Ph.tR+..p.........pLPP...LPDLRFEQ......SYLsSIcsA-...o........................Wt+VAaIT...................................................	0	14	31	50
+8422	PF08590	DUF1771		Domain of unknown function (DUF1771)	Mistry J, Wood V	anon	Pfam-B_10757 (release 18.0)	Domain	This domain is always found adjacent to Pfam:PF01713.	22.90	22.90	23.00	23.10	22.40	22.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.04	0.72	-3.96	30	501	2009-01-15 18:05:59	2006-01-06 16:21:49	5	28	240	1	355	500	1	65.70	29	10.99	CHANGED	-Yp.....clRspAppthppRpchhpcuppAappGDt.....spA+pLSpcuKpttpphcchNcpAAptlacpsNp	..............................Yt.....chRppAtpptptRsphhp..........pAppAappGct.....ttA+tLSppG+tctpphcchscpAAc.tlacppN........	0	112	203	290
+8423	PF08591	RNR_inhib		Ribonucleotide reductase inhibitor	Wood V, Bateman A	anon	Wood V	Family	This family includes S. pombe Spd1. Spd1p inhibits fission yeast RNR activity by interacting with the Cdc22p [1].	20.10	20.10	20.30	20.70	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.55	0.72	-3.08	23	119	2009-01-15 18:05:59	2006-01-06 16:53:36	5	4	112	0	90	111	0	95.50	25	41.59	CHANGED	uuLhoVGMRlRKSVsEGYKT...p..s..............t.s.h..................shtsstt.hssphEhsPFsuh.p.s.shhspsspssss..................sshpthsSup-uhtushs	.....................ssLhoVGMRlRKuVs-GY+o....................................p..sh.................s.htshsshhssth.chhPhsu.h.phs.shhsptttsssp....................sshp..sssppt..t..t.........................................................................	0	16	44	75
+8424	PF08592	DUF1772		Domain of unknown function (DUF1772)	Wood V, Finn RD	anon	Manual	Domain	This domain is of unknown function.	24.70	24.70	24.70	24.90	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.87	0.71	-4.44	75	579	2009-01-15 18:05:59	2006-01-06 17:09:07	6	7	370	0	326	606	107	134.50	19	80.16	CHANGED	Gshhuaoshl............hPAlt......plsssptlpshpslspts....shhhsshhussshs.shlAh..............h.thts..sssshlhsuuulhllushshThhh.plPhNstL.............tthp...sstsssshh....tshhspWstaNtlRolhulhusslh.lhAh	............................................Ghhhshuhhh............hPult...................ph.ss..pt.h.l..t.th.p..t..h.pth.........shhhs.s...hhhsshhs.hhhuh..............................thtt....sss.h..h.hhsuuuhhh.lu.h..hshThhh.......sP.lN.st.L...................................................tthp.......ts.ss..s.ssth..........pphhpcWsthshlRshhs.hsuhshhhhu..........................................	0	115	217	284
+8425	PF08593	MUG2_C	DUF1773; 	Meiotically up-regulated glycoproteins C-terminal	Wood V, Bateman A	anon	Pfam-B_26890 (release 18.0)	Domain	This is the C-terminal part of some meiotically up-regulated gene products from fission yeast. The actual function is not yet known but the proteins are likely to be cell-surface glycoproteins.	25.00	25.00	25.30	26.70	20.10	24.00	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.72	0.72	-3.73	17	50	2010-01-05 10:44:21	2006-01-06 17:21:54	5	3	40	0	44	50	0	56.50	29	13.04	CHANGED	chtht+t.shp+Rp...........sthsssslP......F.sspps.pstLPslsolpDlstLSc.QhppaLpG	...................................aLau+shshs++p...........sttsssshP.........stps.pPhL..sshusIhslshLS..QlShFLsG.	0	11	27	39
+8426	PF08594	UPF0300		Uncharacterised protein family (UPF0300)	Wood V, Bateman A	anon	Pfam-B_20198 (release 18.0)	Family	This family of proteins appear to be specific to S. pombe.	25.00	25.00	126.50	125.80	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.32	0.70	-5.41	6	9	2009-01-15 18:05:59	2006-01-06 17:25:57	5	1	2	0	9	11	0	209.40	25	43.02	CHANGED	hhLpsppssaccLspaLpsGphPLpVLlHHVMLYcaYPsshQ-ALWsAVppYVpppVssstYTplHhhAspp+IGcIRMYLVcPcDIYshsssssWlsIsocsFpshlcLcpshptsslhpspsthpp..lhps.spSspEluWLhhhhulGSsuutFPlHAYLshKpplhpshlPcpl...hhhpcsDptlFpc.pshcchpsa.hpplhpDLshC-pap	.....h....t..pshpplh.aLpssphPlpVLlHHVMLYchYPptlp-uLWpAVppYlpcpsssttYoclHhhAAp++lGcIRhYLlcPcDlaslsssssWlsIsscpFps.lcLcpsh.spslhpppsthpp..lhph.ssospEluWLthlhuhGssupuFPlHsYLsspppl.tphhPpsh...hahpppDphlFps.tshc.hpsa.hpphhp-L..C-p........................	0	6	6	9
+8427	PF08595	RXT2_N		RXT2-like, N-terminal	Wood V, Finn RD	anon	Manual	Family	The family represents the N-terminal region of RXT2-like proteins.  In S. cerevisiae, RXT2 has been demonstrated to be involved in conjugation with cellular fusion (mating) and invasive growth [1].  A high throughput localisation study has localised RXT2 to the nucleus [2].	21.10	21.10	21.50	23.40	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.92	0.71	-4.41	17	118	2009-09-10 20:49:02	2006-01-09 16:37:06	6	2	111	0	90	121	0	136.40	32	32.14	CHANGED	soNRGsKLhppuc.l..ttl..ssssshhpchlpYs..Ghp+tlLp.....................pttsphcp-ts-h-stpp---.-pctp.t.....sPhpplclcElLuPLspsu-lhsHPulS+sapSpsLpcLAhphlthlcpEQsslhphp+LLplhlGD	.......................s.oNRGNKLptpu..chVppttL..ssstshhcctl-as....Ghp+..p..lLp...........................................pssshhDp-ss-l.D.....--.....-p...pc...spt.tst-.-sPasplplc........clLuPLppso-ls.sHPslS+sa...pScsLppLspphhthlcpEptsLhphppLhphhlGD...................	0	18	46	75
+8428	PF08596	Lgl_C		Lethal giant larvae(Lgl) like, C-terminal	Wood V, Finn RD	anon	Manual	Family	The Lethal giant larvae (Lgl) tumour suppressor family is conserved from yeast to mammals.  The Lgl family functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface [1].  The N-terminal half of Lgl members contains WD40 repeats (see Pfam:PF00400), while the C-terminal half appears specific to the family [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.11	0.70	-6.00	13	313	2012-10-05 17:30:43	2006-01-10 12:04:56	5	10	193	1	188	340	0	278.70	24	27.85	CHANGED	slslsplShAs-otELuVuhpoG-VllaKFps..............Nphas...ptpssuh-hp.tphphssp.sstLlDIpcRusssl+pG..FhPhollphp.pGploulppSNIGFVAlGYcsGollllDh.RGPAlIap.-slpc..........lsstpouhsss......lEFuIMphssDsYSSIlllsGTst.GpLhTFKIlPsusGtFsVpFssss...........hsscupIlpIssl......ss-sGpSAhAohsthQ.....sLupGlhlsGhVlsooss-IRllpsspoKssHKsa.chsltssuhuhlsh.t....cppuhlLlsLhtsGpl+sholPsL+EltshplP........hslcuphlppSsl.LtsGD.lhhpsG.pEusLholhsppupt......................tppsspDpLaNssttIPsRPp...lssLQWs+G.otYsosp-LDhLlGGssR.PsSK	.....................................................................................................................................p...........................................................................................................................................................................................................................................................................................................hhhspt..u.hhh..h.h...............t.......h........................................t....h..h......................................................t.p..ptht.......pt..h..sll....so..ccph+l.hshs.s.pp....s..sa.Kth.....cs..shhspu..ssV..h.............hpsuhsLsshh.usGc.lhshSlPu.L+.lhcsphh........shh.chchs.p...shsh..ossGp.slhhs.uPo.....E......lphl......oh.tpst.............................................................................................................................................	0	45	83	135
+8429	PF08597	eIF3_subunit		Translation initiation factor eIF3 subunit	Mistry J, Wood V	anon	manual	Family	This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3).  In yeast it is called Hcr1.  The Saccharomyces cerevisiae protein Swiss:Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p [1][2].	27.20	27.20	28.10	27.50	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.88	0.70	-4.81	40	373	2009-01-15 18:05:59	2006-01-10 13:30:36	5	9	290	5	256	351	2	229.00	27	92.17	CHANGED	M....ssW.D........---h-sssssst.......ssts+W--E...s---slh-SW-..t---pct..cppcsp.tsscspsKtphctchpccp+tpchppccthc............p.sst-phscKtRh++hpc-uDLpsAt-LFG.......................................htssshsslshF.pPpoKp-FpchpcsLspp.lssh..c.pshpYss.ahp-LlRslstsLssssl+KlsooLssLhsEK.KtEKtuc...............sspKKputsts+sslssttcp.stasthssshhDD.....DDFM	.......................................................................pW..-........tpt.p....................hppa-sE......--psl......h-.s.....W-.............tp--pc..........pp........t...p......st.......t....st.......h.p.tKt..th.tt...pht....c+pptpch....tpcph.t....................p.ssp-phsc+h+hc+hpc-uDL.ptAp-.hFG.........................................................t...ssshpslshh.pP.po+p-Fpchsch...Lssp.lsth...pcsh.pYss..alcslh+plsts.....L...p.ss-.......l.KKlsso.LsslssEK.K.pEKtuc.................tttK.K.pst...st.........spsph.s....s...pp....sh....s.s.h.sth....t..s..s.....hh.-D.........-D.FM....................	0	93	144	207
+8430	PF08598	Sds3		Sds3-like	Wood V, Finn RD	anon	Manual	Family	Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins [1].\	    This family represents the conserved region found in Sds3, Dep1 and BRMS1-homologue p40 proteins.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.38	0.71	-4.79	54	585	2009-01-15 18:05:59	2006-01-10 13:48:35	6	6	246	2	375	547	0	209.60	23	51.78	CHANGED	ppshsclsplEppFsph+-ph................Yc-+LspLppcLp.lt..p.........................................Gsps-ahchhpclpcp+chclphsphhpcaplpslcpchps-hptscpcappphppl+-plhsclpp+ht+.lpc-RpphDls........................ssshshph...................................................................hps+phpct...sp.h................................................................................................................p+p+hsptts.htt...hh.........................l................................................................................................hpsp-lt-Dhpsh	..............................................h.pph.plEcpFsp.....h+-ph.................Yc-+LspL.ppcLpplt....p.................................................................sptsEYhc.lppLppphch+l.....phs.t.h.hp..php.lpslcpcattEhptuppcacppthtl+-plhsclpc+...hpc.l...pc-.+p.sh-ls.................ssphthp.......................................................................................................ht.pR.hpp.t...........................................................................................................................................ppp+hs..st............h....................................................h....................................................................................................................................................................Lp..-l.pDht.........................................................................................................................................................................................................	0	102	177	287
+8431	PF08599	Nbs1_C	Nbs1_N; 	DNA damage repair protein Nbs1	Mistry J	anon	manual	Family	This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1 [1][2].	25.00	25.00	25.30	40.60	24.40	23.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.04	0.72	-4.06	5	81	2009-01-15 18:05:59	2006-01-10 13:57:02	5	6	52	0	33	71	0	64.30	74	8.88	CHANGED	pKNFK+FRKVsYPGAGuLPcIIGGSDLlAHsR+KNSELEEWLRQElEEQsQpsREESLADDLFRY	L.KNFKKFKKVsYPGA.G..K.LPHIIGGSDLIAHHARKNo.ELEEWLRQEMEVQsQ+AKEESLADDLFRY............	0	4	6	14
+8432	PF08600	Rsm1		Rsm1-like	Mistry J, Wood V	anon	manual	Domain	Rsm1 is a protein involved in mRNA export from the nucleus [1]	20.90	20.90	20.90	20.90	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.50	0.72	-4.13	11	189	2012-10-01 20:49:39	2006-01-10 16:15:18	5	7	140	0	130	193	0	89.60	23	20.42	CHANGED	AhhLAhhGW.............suhscuphG.....LssCssCaRRLGLWMaKsKpsuths........hstLDllpEHh-aCPWhsspuQossucssttptt.t.....uGWclLspsL..........K	....................AhhLulhGW...................................p.shts...phu.........lhsCptChR+lGLWha...pthcsu.ss...............................s.s.hsshppHhpaCPahs.....p...st.p.....tp......................................................................................................	1	33	53	88
+8433	PF08601	PAP1		Transcription factor PAP1	Mistry J, Wood V	anon	Pfam-B_20528 (release 18.0)	Family	The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2 [1].  This region is cysteine rich.  Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression [2].	22.70	22.70	22.80	22.90	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.50	0.70	-4.76	10	181	2009-01-15 18:05:59	2006-01-10 17:16:00	5	6	130	2	118	186	0	264.60	22	57.66	CHANGED	sS.........htss.pt.hshsstpFsh-hscFsucLstususcssslsK...........tpssstsos.........lsulpspssps.s.sssssss.sosp.ssts.sspp................sshusD..h.tsstsshps.u........sssssoossoPSsuusuasspp.ossusss.P..spSPsshtpsss...............................................hhhp.t.s.s.s.sttssssshshlDssls....sss.h-s.LFtsaREPQcsshsp.DaD.......................................ssLhs-p.shs-.hsPht..sp....s.......supssssppstssphcs...c-s--sVssuccsshLsCocIWDRIoSHPKa..u-IDIDuLCSEL+sKAKCSEsGVVlNpcDVcssLs+a	.......................................................................................ttttst..........................................................................................................................................................................................................................................................t.ss.......t......t...st.t........t..t.t...............pP...........................................................................................................................................................t.............hs....ht..........s..t..s..h.t.hppsppt.h.t..s...h................................................................sshhsct.....sc.ht....s......t..........t.................................t............sst.s..h.ht...p...hpt........pt......tpp.lsst..ttp.hpCscIW-+lp........s.hs+a..u-lDlDsLCsELptKA+CS-tG.lVlpppDlpphlt+..............................................................................................................................................	0	24	58	100
+8434	PF08602	Mgr1		Mgr1-like, i-AAA protease complex subunit	Wood V, Finn RD	anon	Manual	Family	The S. cerevisiae Mgr1 protein has been shown to be required for mitochondrial viability in yeast lacking mitochondrial DNA. It is a mitochondrial inner membrane protein, which interacts with Yme1 and is a new subunit of the i-AAA protease complex [1].	25.00	25.00	62.50	26.00	19.50	22.90	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.40	0.70	-5.44	6	63	2009-01-15 18:05:59	2006-01-10 17:48:11	5	3	43	0	40	59	0	252.20	28	91.40	CHANGED	MulaTPPupstsspD+.................SuspucsotslssstpFasR.PSLGL+LWGPLVPASDNhsGLaoLlulQoslGhhhhpRhRpL.........................................t..hlK+DIADFPoLNRFSpTpGDhah..............uPh........................hpcRFso.....h++sLallsGSlLLsQShLEhsRLThLhYDPWh-EAKsVR-KpFaNslV+aYHEGlDss+hhsKD.hsGp.hshNlPEV+QulAlsRApscApN.lopWFGPl-.YKPMoFsEaLDKlEaaL-hh-a......................hQshpptpcsthshlsplsscsptL-hh.ctNcpN++Rhc+lLcpp.p..s-lscu.uhslhhcupsp.hh...hhRulIL.tDpcsspDl-LcplWslY-PWssLAL-TuLSIKFlPos	...................ahPPst..s.s..tst.................................st.tstt.......p......phh.+.PSlGL.hWGPLsPAsDNh.uLashhshQ.hlGhhhhhhhRth................................................h.p.l..............s...........................................................................................................................................h.......h...h.hhhGshlh.tShLEhsRh..L.YDPWh-Ehp.hR..................................................+hthcsts...hWaGshp.YpPMshppahp+hp.alp.ht...................................h.pht....t..t....h.......hpplp..........pp.p....p.h.ph..ppspphh.p.l...........................p.s.t.ths...........ttp.............+.s.l....shp..p-.php.hh..apPW.pLt.-TphsI+hlPp....................	0	6	22	38
+8435	PF08603	CAP_C	CAP;	Adenylate cyclase associated (CAP) C terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	23.80	23.80	23.80	24.00	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.87	0.71	-4.89	35	461	2012-10-02 17:34:32	2006-01-11 12:58:49	6	11	296	10	293	478	8	154.60	41	33.01	CHANGED	+cPs....phEL.cGpKWhlEp.cssp....slllp-s-hcpsVaIapCpsoslpIKG.KlNulolssCcKsullhDslVSul-llsspshplQVhGplPTIoID+oDGsplYLS+-Sl..ss.EIhouKSSplNl.l..Ps....c-sDa.pEhslPEQacoph..cs......uKLhTpss-ps	......................................tPshhEL..-GpKWhlEppcsps......slllp-.s-.hc.QslaIa+CpsoslplKG..KlNuIol......DsCc.KhulVh.DslV..u..s..lEllNspslpl..Q..........V..h........G..pVPTIoI-KoDGsplYLSc-SL...ss..EIsouKS..S-hNlhl........Ps...........t-uDa..p.................EhPlP.E..Qa+ohh...ps.......sc..LhTpss-h.....................................................	0	99	154	233
+8436	PF08604	Nup153		Nucleoporin Nup153-like	Wood V, Finn RD	anon	Pfam-B_56527 (release 19.0)	Family	This family contains both the nucleoporin Nup153 from human and Nup153 from fission yeast.  These have been demonstrated to be functionally equivalent [1].	25.00	25.00	47.40	39.50	16.40	23.50	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.97	0.70	-5.83	4	78	2009-01-15 18:05:59	2006-01-11 14:59:46	5	9	42	0	36	71	0	425.60	55	34.34	CHANGED	PoTopsu.Nas-.sLoRPoLaRuH..LsFs.L-........SsALpsQPSoSSAasIuT..SGFSLlKEIKDshSQHDDDNISTTSGFSSRASDKDlssoKssSlPsLWSPEs-RSpShspsoppSsKKPuFNLSuFGo.Ssu.GNsSlLs.opLGDSPFYPGKTTYtGAAAs.RSSRhR.sTPYQAPlRRQhKAKPhu.uQ.hGVTSusARRILQSLE+MSSPLADA+RIPu.ssSsL...Spsh-p.slDh.c..uK+cKhD..hPPVQRLsTPpshslusNRShahKPoLTPuus.ptsscclDp..sspsts+cssL.tps.cppp.......huYPhhSoPAuNulos....GGGKMpRE+soa.huoK.hp.EEl.-sPlLPcIsLPl.oosuLPoFsFoosphosT.p.oPlshso.A.oppsphps....sSs.FoFSSPIVKST..cuss.sPS.Shsho...FSVPshKh...scsouscshl.slhpstss+sAssposssc-.....p.Ghh+PAKTLKpGSVLDhL+oPGF.SSPs.pssAsp.sssoP	.................................................................PSTopou.NasD.VLoRPoLaRSH..LshohL-........SsuLaCQPSTSSAhsIGo.....SGFSLVKEIKDSTSQHDDDNISTTSGFSSR..ASDK.DlsVSKssSlP....LW.S....PEs-...RS+..S......lSQpouoSSKKPAF.NLSAFGoLSsSLGNoSlLpoSQLGDSPFYPGKTTYGGAAAA...Rpo+hR...sTPYQ.A..P....VRRQhKAK.hs...uQuYGVT......SSTA.RRILQSLEKMSSPLADAKRIP.S...s....SSPL...sSslDRSslD.h.s.shQu.K+c+.hDSph...PPVQ+Lh.TPKslSlAsNRohYFKPSLTPuuchp+sspRl...Dp..cpsst...h.ccphhs.s..p..s...tpp.pp......shSYPp.hS.hPAuNGLoSt..............sGGGKM+.RERoph...su.oKs.E..EEh..ElPVLPcISLPI.oooSLPoFsFSSP...oso.us.S..P.ls.so....t..uhs.sclphsoss...ssuSPhFp..FSSPIVKST..pAslhPPo.S....lGFT...FSVPVAKs..........sEhs..us.s.s.h..pslh.os.ss..pc......sssls.S.sspcc....pph-GsF+PAK..hLKpGSVLDlLKoPGF.sSsphs...s.u.t..........................................	0	7	9	17
+8437	PF08605	Rad9_Rad53_bind		Fungal Rad9-like Rad53-binding	Wood V, Finn RD	anon	Manual	Family	In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways.  DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 Pfam:PF00498 domains [1]. This region is structurally composed of a pair of TUDOR domains [1].	22.00	22.00	22.60	22.00	21.90	21.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.67	0.71	-4.37	8	79	2012-10-02 16:56:36	2006-01-11 17:18:52	5	3	79	0	58	87	0	136.30	29	10.55	CHANGED	DsuhLspsDII.tsAVWsta..shsaYPG+llup..spspst.shVcFE-Gs.h-VpssDlahLDlRIGDpVcsct...s..palVpGLcsphot-sts.........I+ClRGYsTVhL..++hpp...uG+lu.pslhp.slScIal-lppW	.......................ls.pplh...usWsth...shtaYPuphluh...sssp.p.hhVcF-Dup..tclcsps.l.+h......L-LRIGDtV+lct...s+hs.alVsGhppp...s...tss.t............lpsl+GasoVhL..Kp+ps......sG..th.spp.s.lhs.PlSpIaL-ht.W............................................	0	7	26	49
+8438	PF08606	Prp19		Prp19/Pso4-like	Wood V, Finn RD	anon	Pfam-B_6384 (release 18.0)	Domain	This regions is found specifically in PRP19-like protein.\	      The region represented by this family covers the sequence implicated in self-interaction and a coiled-coiled motif [1].  PRP19-like proteins form an oligomer that is necessary for spliceosome assembly [1].	21.50	21.50	25.60	30.70	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.16	0.72	-4.24	30	339	2009-01-15 18:05:59	2006-01-11 17:41:08	6	30	290	0	243	334	5	69.20	57	13.94	CHANGED	ssssSIPuLLoshQsEWDAlhLEsFsLRppLpps+pELSpALYppDAAsRVIARLh+E.RDpA+ptLspls	.......s.osTSIPulLpshQ......sEW.....DAlMLcoFsLRQQLppsRQELSpALYQHDAAsRVIARLpKE.+spAR-ALupl.p....................	0	90	140	203
+8439	PF08534	Redoxin		Redoxin	Mistry J	anon	manual	Domain	This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.96	0.71	-4.65	68	9684	2012-10-03 14:45:55	2006-01-12 14:51:33	5	39	3870	123	2384	24093	13509	140.60	20	71.03	CHANGED	p......sGsp..h.P..shs...............h.t.stsspshslsp.......hpGKp.hll....shhsuhasPs................Cstpt...hlpch.sphhpspusshlsl..........ssssDsh........stphhuc...........ps.shhh.hsD..t.sushscshG..h.............ts.phhllsccG..pltththssts.t........hsshpshL	....................................................................Gp...h..P....shp........................h.........t...t...s...h...p....p...h....s...h......ss.........h.p..G.K.h....hl.l.....s.h..a.s....o.........a.....s.s....s.....................Cp.t.ph.........h.p.ch....tp............t.....s.....p......s.......s......s...l...l.s..l....................................s..s...s...s..psh............................st.pa.hsp..............................................tu.h.s...h..s....h....l.........h....D..............s...s...u...p.....h....s....p.....s....h..G..l..h..........................................ts...p.s....h.l...l....c..p.sG.....pl.h.h.hphss...................................................................................................................................	1	675	1408	1941
+8441	PF08608	Wyosine_form		Wyosine base formation	Mistry J, Wood V	anon	manual	Family	Some proteins in this family appear to be important in wyosine base formation in a subset of phenylalanine specific tRNAs.  It has been proposed that they participates in converting tRNA(Phe)-m(1)G(37) to tRNA(Phe)-yW [1].	21.30	21.30	21.30	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.83	0.72	-3.86	72	579	2009-01-15 18:05:59	2006-01-12 16:46:12	7	11	497	2	327	541	82	61.60	33	12.94	CHANGED	hupPsalElKuhh..ahG.Sp....tLohsshPtap-V....h-Fsptl.p.....ht.......Yplss-pttSclsLlup	......upPsalElKu.ss..asG.Ss...ttLohs.shPhap-V....hcFs.tl.t...............................................atlss-+t+SsssLlA....................	0	95	193	273
+8442	PF08609	Fes1		Nucleotide exchange factor Fes1	Mistry J, Wood V	anon	Pfam-B_36022 (release 18.0)	Family	Fes1 is a cytosolic homologue of Sls1, an ER protein which has nucleotide exchange factor activity.  Fes1 in yeast has been shown to bind to the molecular chaperone Hsp70 and has adenyl-nucleotide exchange factor activity [1].	22.30	22.30	22.30	22.60	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.24	0.72	-3.50	17	214	2009-01-15 18:05:59	2006-01-12 17:19:00	5	9	186	0	151	200	0	92.50	33	31.88	CHANGED	M-p....LL+WSIpss..........................ssspsussssssP..............................lsPchLspLF..GGPs-AsLMKtAMtslps..scsoLEsKlIAFDNFE.LIEslDNANNl	..................................................................hppLL+WoItso............................................ts..s..tps.sps...sp.s..............................................pth.sschL.pplh.....tsPs-upLMKpu.......hp....llps........spso...lEs+hhAhDshE.LlEslDNANsl...	0	46	86	129
+8443	PF08610	Pex16		Peroxisomal membrane protein (Pex16)	Mistry J, Wood V	anon	manual	Family	Pex16 is a peripheral protein located at the matrix face of the peroxisomal membrane [1].	25.00	25.00	29.20	25.60	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.13	0.70	-5.44	18	280	2009-01-15 18:05:59	2006-01-13 09:38:16	5	9	214	0	186	267	0	296.50	26	84.37	CHANGED	hp.tYpcalhcNsss...lu...plEosl+....hloYllsGRFscuchhSEhlaoh.pLLshhpDtIlppthpp...............................................h.ts..hp+lshhLshlpasElhlEhuAc+hhG-ps+WhsllhlphhKAshRlhl.LhhppuchlhosPls.h-ccsptppt.ppptspss...............................psssashpRo....G+sl....t...Ps.t.p...ht......lspshsppshct...t..p.lst.thlAEhLaIsRPLlalluhtt........hup+S........WpPWlluhul-hhShpLhpcpcph.........osh-+tEhpRRsht.....lhaah.hRuPFY-paT+s+lhpllphl.ptlPlhullutslhDYLshWpch	......................................................................................hYppaltcNss....ss...plEosh+..........sloal...ls..G.Rats....u.chhS.EhlaohspLlshhpD....t.llppthpp........................................................s......pplhhhLphlphsE.lhhEhsA..p+h..hG.cpt..............+Whllsllphh..KA...hh......RlhL.lhhh.p..sp.h.....hsPs..ls.h-hcspt.t.tttt..........................................................................................pp.sash.Ro............shsl.pl.ss.........sshp......h..........hpphhp.tpphp............p..l.........s.......h...t.h.hAEhlaIhRPLla.hlslth................hsp+S................WpPWlluhsl-hsuh.....p.Lh...pp.t.ht..............................................othE+t..Elp+Rshh............hhhal.hRusFY-......pho.csh.l..thhphh.p.hPhhs....hlst.l.-a..hhpp........................................................................................................	0	64	101	148
+8444	PF08611	DUF1774		Fungal protein of unknown function (DUF1774)	Mistry J, Wood V	anon	manual	Family	This is a fungal family of unknown function.	22.80	22.80	23.30	23.80	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.35	0.72	-3.83	14	95	2009-01-15 18:05:59	2006-01-13 10:43:53	5	4	86	0	77	87	0	93.50	42	31.85	CHANGED	RIlANVFIWshhlhsthalhhhpDaslGaulShLhhuLultQhhhKlhALQWIFAFlIhulhhVhSlhsulsthht+chhhp.........-pERtPLLs	.....RIlANlFI..Wsh..hlaGthaIhh..hpDashGauLSlLohuLultQhh.h..K..l.IuLQWIFAFlIhulhhlhSlhsulsthhs+sh.htt......ssDpERtPLL...............	0	13	36	60
+8445	PF08612	Med20	TATA_RF; 	TATA-binding related factor (TRF) of subunit 20 of Mediator complex	Mistry J, Wood V	anon	manual	Family	This family of proteins is related to TATA-binding protein (TBP). TBP is a highly conserved RNA polymerase II general transcription factor that binds to the core promoter and initiates assembly of the preinitiation complex.  Human TRF has been shown to associate with an RNA polymerase II-SRB complex [1]. This Med20 subunit of Mediator is found in the non-essential part of the head [2].	25.00	25.00	25.00	28.10	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.61	0.70	-5.21	32	235	2009-01-15 18:05:59	2006-01-13 11:26:05	6	2	198	11	160	239	0	213.80	26	92.51	CHANGED	Msl.sh...............lhh..sssp...s.tTlsphpcpLps.tsshtGpWsl-hcha+ssspshs..........................+hhhsls.ocpPspshhlhssss...........................................................ss.sDshhphlhtKlpshapp+pslps-ssts.Ypl.....GDFhlRlGsVh.ss...sh+GlllElEa..............................................................................................sssthspstsllc-Flpph........s.sts+.sh................h.ppthspl.................................hDhshQ.Yhclhs	....................................................................................................................t................hh...sssp......s.tslp.hpcpl.p......suttt..Gpasl-hcha+ss.spshs....................s.......................+hhaslp.Sch.P.t.psFslhcsss................................................................................................shhsD.s.hshlh.hKLpshapp.+pss+l-spus.Yph...............sDFhl+lGsVp.ss...........sh+GlllElE.Y.............................................................................................tssss.hss...shpllpEFlppa............thstsp....................sshh.tpptsthh...............................................s..DshhQ.Yhchh.........................................................	0	45	76	127
+8446	PF08613	Cyclin		Cyclin	Mistry J, Wood V	anon	Pfam-B_6792 (release 18.0)	Family	This family includes many different cyclin proteins.  Members include the G1/S-specific cyclin pas1 [1], and the phosphate system cyclin PHO80/PHO85 [2].	21.00	21.00	21.00	21.00	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.84	0.71	-3.80	9	1457	2012-10-03 00:42:12	2006-01-13 14:18:39	6	13	314	4	1040	1807	12	153.60	21	39.34	CHANGED	ccllptlsthlsRhsshssssspsSppstss.ps....................................Fhsh.s................................................................PslultsYhtRlp..........+astsss.....sVhlssLlYlcRlhc.........tphp.shslsuhNh+RLhlsulhlAoKhhsDhpho.Nppau+luGlsLcELNcLElsFLhhlDFcL	..........................................................................................................................................................................................................................................................................................................................t....................................................................................................................................................................................................................................................................................................................s...h.s.....l...p.a.l.tclh........................p.hs.t.h.o..........sshlhs.....hhYl.c.Rltt....................................t......h...h.l..s..........p..........h..s..........h+..R.......l.........lls...ulhlAsK........h.......h..s..D......................h.....a....s....N....p....t....a.u........c.............l........u.........G...l.........s........h.........p..E......lNtLEhpFLh.hlsacl.....................................	0	377	618	878
+8447	PF08614	ATG16		Autophagy protein 16 (ATG16)	Mistry J, Wood V	anon	manual	Family	Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells.\	      During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway [1].	35.00	35.00	35.00	35.40	34.90	34.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.43	0.71	-4.48	16	330	2009-01-15 18:05:59	2006-01-13 14:49:26	6	13	233	8	202	320	1	170.80	25	44.66	CHANGED	W+pclhcpLppRD+hp.psap-lhpph.................ppL.-csth.th.sptLps......t.................tt..usshsssht.....t.tthhhthpt-Lsphh+ppuchtppllplssplpcpcpchtppppplpplppphppLcpcl+cLcpplpp+p+sspsLpDEltuLplphshLE-+lp+lpcENppLlpRWht+tspEA-tMNp	.................................................................W+pch.ttLp.Rsphp.th.........p....lh.th..................spLh-.+sshhph.stphp.................t...t...t..........................tt......s....t..t..st...h.t.s..s.tht....pht.....phhhphppELsphp+ppuc...........hspplhphspphpphcp..phptpptp..lsphppphspLcpchpchcpplp-hp..+t....p...........plp.DEhtuLp.....l...ph.......shhEc+hcch.......pcENpcLlpRWMtcpsp-ApthNt...............................	0	53	96	150
+8448	PF08615	RNase_H2_suC	RNase_H1_sml;	Ribonuclease H2 non-catalytic subunit (Ylr154p-like)	Wood V, Finn RD	anon	Pfam-B_36578 (release 18.0)	Family	This entry represents the non-catalytic subunit of RNase H2, which in S. cerevisiae is Ylr154p/Rnh203p Swiss:Q12338 (. Whereas bacterial and archaeal RNases H2 are active as single polypeptides, the Saccharomyces cerevisiae homologue, Rnh2Ap, when expressed in Escherichia coli, fails to produce an active RNase H2. For RNase H2 activity three proteins are required [Rnh2Ap (Rnh201p), Ydr279p (Rnh202p) and Ylr154p (Rnh203p)]. Deletion of any one of the proteins or mutations in the catalytic site in Rnh2A leads to loss of RNase H2 activity [1]. RNase H2 ia an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. It participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.	20.80	20.80	21.80	20.90	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.82	0.71	-4.33	43	277	2009-01-15 18:05:59	2006-01-13 16:09:50	6	8	240	10	196	272	0	130.50	24	66.56	CHANGED	ssplLPscIp......asGsss.sscaFps......................................................pspppspph.........................................................hpsaFRGRpLhGcplslPp.uapGhlhppspph...........................................................................scspspp.......................................................................................................hp.pupFpc..hsh......................................Ws+-shP.tssDshhcsl.cahplupsl	...................................hphLPscIp........hsG.sss..sspaFps..............................................................................................................t..ptpstth.............................................................................................................................hpshFRGRpLpGppls..lPp.GapGhVhpp.ppp.....................................................................................................................................................................................................................tptpspt................................................................................................................hpspup.F.sp..hsh.....................................................................Ws.h-phP.sssDs.hhpuh.pWhplAps..............................................	0	72	115	164
+8449	PF08616	SPA	SPB_interacting;	Stabilization of polarity axis	Mistry J, Wood V, Bateman A	anon	manual	Family	Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body [1]. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation [2]. and in S. cerevisiae it functions as a polarisation-specific docking factor [3].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.20	0.71	-4.37	27	396	2012-10-02 14:18:06	2006-01-13 16:54:27	5	12	241	0	281	674	2	111.20	28	17.65	CHANGED	tpshLphhshhss.lhhL.hsAlLtpKRllhluhppsusp..........lspalLuhstlhss...sshhpth.tp....FPY..hslSp....l-tLpchsu..........aIsGssNPhF.....cpppph.WDllhDl-ssplhlup	................................................hhphhsshh.hp.lhh.L.aphlLhtc.lllhuss....ss..................................suEhVLuLs..u...llss...........ht.hp.th.tph........................hP...Y..hslpc.............hsch..p..t..ssu..........................................hIhGV...TNPhF.......tpphph..W.s.h.l.l..clsssph....s..........................	0	97	144	217
+8450	PF08617	CGI-121		Kinase binding protein CGI-121	Mistry J, Wood V, Bateman A	anon	manual	Domain	CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1].  PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation [2].  Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.	21.40	21.40	23.00	22.30	18.30	21.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.79	0.71	-4.56	46	397	2009-01-15 18:05:59	2006-01-13 17:30:53	5	8	349	6	278	392	48	150.60	22	83.16	CHANGED	acslpss..........t.lhp.hhttp...................thphshlsuph...................lhutp+lhtAlh+Alp................shpps.phpo+sltsEIlhpLSssppIs-ul+paGlpcs.sssllslhls.................sp.....ppthpc...lhp.hlcupth.......................shsp..t...tphsDhppl+KhYKlsstt.......................t.tpltphllsphAl+	.................................applpNs.....lhpphhttp...............................phshlsush.......................................lsshhplhsAs.+A.lp.................................sh.pps....chpo+slpoEllhsLSsspp....Is.-Ah+caGlscs..sss.llllhhs..................................pppp.hpp.......ltp.h.lcGptl.......................................................s.hpp..........phschspl+K.hYclss.t..........................t.tpl.phlhtthuh...........................................	0	83	159	233
+8451	PF08618	Opi1		Transcription factor Opi1	Mistry J, Wood V	anon	manual	Family	Opi1 is a leucine zipper containing yeast transcription factor that negatively regulates phospholipid biosynthesis [2].  It represses the expression of several UAS(INO) cis acting element containing genes and its activity is mediated by phosphorylations catalysed by protein kinase A, protein kinase C and casein kinase II [1].	20.10	20.10	20.10	20.60	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.29	0.70	-5.56	4	279	2009-01-15 18:05:59	2006-01-16 10:36:52	5	4	125	0	221	291	0	159.50	14	68.11	CHANGED	Ds-hh.tsStLstl+............................................to.thYppoKsaSPRhR.GAEhVEpsl.....PVssTlsssspcoGlEusscathpphspspsSSso..pt.pp+..................pppp....c+lpushsshp.p-tpts..o.-h......................susscss.s.sspThsshDDpposphoso...........sptsussssspppSpWQp...clhlosouLu.uMSpEShKSL+YCLphL+hAsu+LtpslstLpsslschs.....psshstshs.............tpssptp...hspplTtLKtDVluTI+pVlcVVupYAGuALPEsARNhVRpalLSLPtRWupsopoo........................................ssttP..sppstsuhsspAAp+lLsLApEuLDhhuplhsllspoL-+AEtWsE	.....................................................................................................................................................................t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	46	115	186
+8452	PF08619	Nha1_C		Alkali metal cation/H+ antiporter Nha1 C terminus	Mistry J, Wood V	anon	manual	Family	The C terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an execessive loss of ions and water [1].  This  domain is found with Pfam:PF00999.	23.30	23.30	23.40	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-12.81	0.70	-5.20	25	146	2009-01-15 18:05:59	2006-01-16 11:42:25	5	5	122	0	91	137	0	434.30	23	49.53	CHANGED	WMsRLP+lspsu+.ShSl+RsDTpss..sstp..t..................hs.sshs.TsGlPht.hGGhhRRh+..cccpcsts.....................sp...sshptcRcpc+cc.psthhshG...shspssh...............hPp.cttps..pt...........p.ttpttt.t........................pppsp.sptsp..sppc-ptpp......sspAYtEGcplIIEDccG-llcshclsptpsttt.............................spscs-tspcshs.....s..shtpl++plupa.shttt.......................tthc+sps..................scs+pcpsaAYphsNpIIlEsEDGEVl+RYcIs.s+sp..................sppscp....usV....ls+shohlGlcs...............................................................sppp..tp.ps.tspsppplstcpssspclhsstcsp.........................................stsspsh.sspscpplpcphsp.httsss.............t..s...pspspcDo-s-s......................................p..--ppETssER+RRLuALGphs.ssc-c-DcE	...............................................................................................WMsRLP+lpptu+.ShShp+sDsps...tp.t.sp..................hs.sshs.s.Ghs....GshhRRp+..cccptppt......................spp...ssht.p+p..cpc...thhshG...shsposh.......................................................................hPp.+p.ps...........................t..................................................................pppsttppptp.p.pp.p-pttp..........shpsYpEGcplIlEscpG-llchhchpptp.tt................................tpstspt.ttpshs..........shtph++thssh.tht.tt.......................................hp+tpp.....................tcs+.pppshAYphuNs.....lIlEsEDGEVl++Yclssctt....................spp.ps........ssl..........ls+hhohhGhps...........................................................................................................hsppph.tphpph.sspsp.....pphspp.......sss.pthht.tppc..................................................................................s.t.ttphtp.....st..t.t...t.........................t......t..s.stp-s.psps....................................................tttpptET.sERcRRLsALG.hs.s.....tpppD.......................................	0	14	45	76
+8453	PF08620	RPAP1_C		RPAP1-like, C-terminal	Wood V, Costanzo M, Finn RD	anon	Manual	Family	Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11 [1].\	  This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.	21.10	21.10	21.10	29.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.39	0.72	-4.13	35	280	2009-01-15 18:05:59	2006-01-16 16:11:19	5	4	247	0	201	281	2	73.90	43	7.90	CHANGED	spphRFDFcGsLl................ssppp.....tshssppGLHHHu-sPchAGYTlsELhpLuRSohsuQRslAlpsLG+IL.h+hspt	.........h.phRFshpGpLl...................................s.p.s......hslPsphGLHHHG.--P-tAGYTltELhpLuRSslssQRslAlpsLupIlh+htt.t.........	0	64	106	161
+8454	PF08621	RPAP1_N		RPAP1-like, N-terminal	Wood V, Finn RD	anon	Manual	Family	Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11 [1].\	    This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.	23.30	23.30	23.30	23.80	22.50	23.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.31	0.72	-4.37	39	266	2009-09-11 10:38:13	2006-01-16 16:14:21	5	4	229	0	189	264	2	48.20	35	5.46	CHANGED	sppIcpENhppLp..............sMStpEItpEpcELhssLDPpLlphLh+Ruptcpss	........ppIccENhp+Lp..............sMS.cEIhpEppcLhspL...DPsLlphLhpRtphct..p.................	1	56	98	151
+8455	PF08622	Svf1		Svf1-like	Wood V, Finn RD	anon	Manual	Family	Family of proteins that are involved in survival during oxidative stress[1].	25.00	25.00	147.40	61.10	23.40	18.10	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.13	0.70	-5.45	28	181	2009-09-11 15:23:04	2006-01-17 13:27:54	5	2	133	0	129	169	0	327.80	39	86.05	CHANGED	TsVETQTFYFss.su.phGFsQlIaSNlh.Gl.psTsQFsh+lFsscss............c.slWpSspLcN..Fc.-tssFhA....DslulcL..............sc-usp.................YsIKusl........scculV-LshpR..hsPGFplG...csGsoaY.............GsD.psPWGoMRHsFWPRssssGTIss...........ps..............................................................psl-lps......huhFltAl.QGMKPHHAAupW.NFlsFQo.........tpaSAlhMEFTTP.SYus............TpVslGuIsccscI...lhsus................s.sslpHhpscpDspssWshPpsIcapasGpsp-..scs.ph........................................lpGsL.............tphl-RlDVMAElPsFVKsIVuuVAGTKPYIYQYs....pchslclphst........p..pEcGhhasEsTFIS	......TsVETQTFYhhs.ps.hhuhsQlIaSNlh.Gl.asssQFshKlFsscss............p.plWpSspLpNh...F................p.....-thsFhu....DslulcL..............sp-sss.....................YpIKusl........scpshVslplsR..hsPGFthG...csGsoaa.............GsD.psPWGpMRHsFWPRspspGoIss.........cc..................................................................pslchps..........huhFlhAl.QGMKPHHAAu+W.NFhsFQo................s...aSAlhMEFT.T.P.SY.us............TpVslGulscc.scl...lhsus...................s.spspHhso.ppDspssWs.PpsIcasasGpspc...sp..ps............................................lpusL.................tphl-RlDVMuElPuFlKsIVuulAGTKPYIYQas....................pphs.h..clphss................-....pEcGhhasEuTFIS..............	0	32	65	106
+8456	PF08623	TIP120		TATA-binding protein interacting (TIP20)	Mistry J, Wood V	anon	manual	Family	TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription [1].	25.80	25.80	26.20	25.80	25.00	25.70	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.02	0.71	-4.67	23	345	2009-01-15 18:05:59	2006-01-18 09:29:55	5	14	251	3	238	339	1	164.60	44	14.11	CHANGED	sLIhshL............splLPhlhs-Ttl+sELlRcVpMGPFKHplDDGLElRKsAYEslYoLL-.....oshupls...lhch.hs+lhsGLpD.cpDI+hLsplhls+L........sslssctlhp+....LD..........plspsL+ssLs.tKlKssAVKQElE+ppEhhRosL+hshsltpph.......ssspsss.............tWspahcplpps	................................LlpshL.sp.lLPhLY.sETpl+pELIREV-MGPFKHpVDDGL-lRK..........uAFEChYoLL-.............osl..spl.c..........lh-F.ls+.l.tsGL....cD..caDI+....hLsaLMLs+L........usls.PstllpR.......LD.........................pLlEsL+sTho.tK.lKssuVKQEhEKp-EhpRSshRslsuL.hpl..................spsppss.................hhppa.pplpp.s.................................................................................................................	0	79	122	186
+8457	PF08624	CRC_subunit		Chromatin remodelling complex Rsc7/Swp82 subunit	Mistry J, Wood V	anon	Pfam-B_56720 (release 18.0)	Family	This family has been identified as a subunit of chromatin remodelling complexes.  Saccharomyces cerevisiae Swiss:P32832 and its paralogue Swiss:P43554 have been identified as subunits of the RSC chromatin remodelling complex, and SWI/SNF chromatin remodelling complex respectively [1].	25.00	25.00	35.90	74.50	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.46	0.71	-4.26	22	230	2009-01-15 18:05:59	2006-01-18 11:32:37	5	3	133	0	176	233	0	138.20	50	24.36	CHANGED	hsltsDEhhls.pDPcGEp..........Klcc.GpLtGGRcY+h+TFTlh....s+G..cplYMLuTEsARsl....GaRDSYLhFppH.sLaKhlsspsEKpcLI-pslIP.....SY+uRslslVTARSlF+EFGA+lIhsG.......++ll........DDYacpcAtp....pG.s	...................h..h.sDEhhh..tDspGEp..........KVDp.GpLhGGRc.Y+sRTFsls....sRG...c+LaMLuTEsARsl....GaR.DS.YLhFpKp+pLaKIIsspsEKcDLIcp..-llP....aSY+u.R.p.IulVTARShFRpFGA+lIlsG................++Vh........DDYapscARcpG..h..................	0	41	91	147
+8458	PF08625	Utp13		Utp13 specific WD40 associated domain	Wood V, Finn RD	anon	Pfam-B_8625 (release 19.0)	Domain	Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end [1].	21.00	21.00	21.30	21.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.65	0.71	-4.54	35	326	2009-01-15 18:05:59	2006-01-18 11:48:04	6	20	280	0	230	328	4	140.80	32	16.82	CHANGED	EQpLpNhlpptcYpcAlhLALsLc+Ph+Lhsll....cssl..............p-ppuh....ppl-......psltpLss-Qlh.....pLLchhR-WNTNu+ssplAQtlLpslLpphsssc.Lhpls....................u.......................ltcllEuLlPY........................oERHapRl-cLlcpoYhlDYslppMs	.............................................................-QpLpNhlp.p.t.capcAltLAlpLs+PtplLslh.pshh.....................................pctpsh.....ptl-...........psltpLsp-plh.......tLLphh+cWNTNuRpsplAQtlLtsllpphsssc.lhpht...........................................u.................................hpphl-uLlsY.......................................T-RHapRlsc.Llppoahl-asltpMp...........................	0	81	128	190
+8459	PF08626	TRAPPC9-Trs120	Trs120;	Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit	Mistry J, Wood V	anon	Pfam-B_15686 (release 19.0)	Family	This region is found at the N terminal of Saccharomyces cerevisiae Trs120 protein (Swiss:Q04183).  Trs120 is a subunit of the multiprotein complex TRAPP (transport particle protein) which functions in ER to Golgi traffic [1]. Trs120 is specific to the larger TRAPP complex, TRAPP II, along with Trs65p and Trs130p(TRAPPC10). It is suggested that Trs120p is required for the stability of the Trs130p subunit, suggesting that these two proteins might interact in some way [2]. It is likely that there is a complex function for TRAPP II in multiple pathways [3].	19.30	19.30	19.40	20.00	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	1185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.79	0.70	-14.13	0.70	-7.23	9	449	2012-10-04 00:47:01	2006-01-18 12:57:28	6	15	255	0	329	471	2	725.10	15	78.18	CHANGED	Mp...sthS..h.ssuplRslVlPI.GchspppFpcahphltpp.sclpLtDl...hspppps.FssQsaspGplhhcFhhus...s.p..hcDFpsaRKshslIGlssh.ps.shs.....h..hpcpYPssls.pphhhFs..Ppsp........tp.cph.shF..stsp.p..pthcolhpDlstshLhshpsa.....plol+SsssI............................................................sh.ssshsopssluS...pp..+spp+p.GR..KhhGsahLLAGph.DAhppahpAlthh+tssDhLWhuuALEGhssshVlhpaht.sh....................................spht..sshp...............................................sL.p.lphhhscll.hYppuh.p.pt...sPtlh.hEuhL+hh+hhhth..................................sph-lhphl.pshthplsphshp-phplYuthAphauslGhpRKpAFhhR.lhhth.s..........................shtt........hhttlhthhsls.pscu.phtsphtp.t...............WssLQhplLp.hlpsu.phsD...hhphsshLLppahphlssspQpplhptlppsh......hpshplshsah.P.h.hth.................l.h....t....pslsp.........spphs.tPF.asPapp......htssss.p..hhhlhs-.sphplpltNPhsF-lplpsltLssctsph.........................................................pshshuhhl..Psu.chhhLshhshpsGplpl.Ghplphhss.sthhh..s.p.......................cssp.................slpllPs.PtLplhs...............t.hossshhLh-GEppphhIplpNtu.shslsplphsh..ps.c.h.ph.h....sthh.stch..hp.....h....hp............slpPsthhphplp...................................................sstts...hpt.thllp.u.pt..-top.ah+pLslPlplslh.ulclsphchlsh..................s.p..........s..p.....ss.chpLLlL-hhNuhtc..tlp............h.h.....sshtspphhlcsststRhllPlc+h...thshs.hshPpl.ppp.hlps..thstt-chph+ch.hhhppllp+lpspW+.spsp.....pGplsl+sh..p.LssphhphL..s.lphthpl.tssppt...p.tp.................hth.ss.hhshchhlh.psppsls............hhsh..hstpsshh..p.ppplLhsGsLpph.....lpstspsshphshhh	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....R..h.hu.h.h..u....u...h.........u.....................................D..W.u.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..................................................................................................................................p.th.............................................................................................................................................................h..apsh............................................hh.t-.hth.h.l.Nsh.h.pl.lpphtl...p.h.................................................................................ps.............h...l..........t...............h.......l...hh.s............t...............G.l...l.....G..h...ht...........................................................................................................................................................h.lh...P.h.h....................................hhtGp...h.h.h.N.u....h..h.h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	116	199	276
+8460	PF08627	CRT-like		CRT-like	Mistry J, Pilcher K	anon	Pfam-B_67420 (release 18.0)	Family	This region is found in proteins related to Plasmodium falciparum chloroquine resistance transporter (CRT).	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.76	0.71	-4.21	3	27	2012-10-02 19:55:49	2006-01-19 09:12:24	5	3	19	0	16	29	3	103.40	26	25.10	CHANGED	-EKpPLLSsIN-sDD-.NapDlNlKoPlshhSNIKKcSl.p+FKsaLKNSMSKETlTILIYVVLYIlSGVINSVLLKKVMNKFTNYGFFLSQLTNYGYVPIFGAlshYKIaFTsDIPKETRsFPQaKFVI	.................................................................pthhth.......................................................tcsh.lhlhhlshlhsuVhNplLhKhhhhshpNYs.aFLsQl.TshsYlsl.aaulhhahhhhtstlsp-.hthPph+Fh.........................	0	10	13	16
+8461	PF08628	Nexin_C		Sorting nexin C terminal	Mistry J, Wood V	anon	Pfam-B_5897 (release 19.0)	Family	This region is found a the C terminal of proteins belonging to the sorting nexin family.  It is found on proteins which also contain Pfam:PF00787.	22.30	22.30	22.50	22.70	20.80	22.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.30	0.71	-3.99	24	634	2009-01-15 18:05:59	2006-01-19 10:04:24	7	21	243	0	395	596	0	110.60	26	11.49	CHANGED	WLR.Rsllshlp....phhG...sTIp+hlp-plp.plhs-cplsphlshl+-sla......PsG.........phtp.s.....R......oppp+tcscppAp..phL.hphlP-hlspllGppssppuhpplFssLQpthl	...........................................WLp.+sl.lshlp....ts.hG..........ss.lp+.h....lpcp....lp..lhs-pplsphlphl...+.-uhW...............PsG...............................htt.s........sR...........................................otpp+t.cscp.pAp....ptL.h.............shlP..-hlspll...G...ppsspcuhtclFpsLQps...........................................................	0	112	184	296
+8462	PF08629	PDE8		PDE8 phosphodiesterase	Mistry J, Vasta V	anon	Pfam-B_72889 (release 17.0)	Family	This region is found in members of the PDE8 phosphodiesterase family [1].  It is found with Pfam:PF00233.	25.00	25.00	28.30	30.80	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.33	0.72	-4.17	2	24	2009-01-15 18:05:59	2006-01-19 11:07:15	5	5	13	0	8	46	0	49.50	77	6.74	CHANGED	MGCAPSIHVSQSGVIYCRDSDESsSP+QTTolSQGsAAsL.GLFlpTDAA-s	.MGCAPSIHVSQSGVIY..CRDSDESNSP+QT.TS.VSQG..PAAPL.GLFVQTDAADA..........	0	3	4	7
+8463	PF08630	Dfp1_Him1_M		Dfp1/Him1, central region	Wood V, Finn RD	anon	Pfam-B_28140 (release 19.0)	Family	This is the middle regions described by Ogino et al [1].  This region, together with the C-terminal zinc finger (Pfam:PF07535) is essential for the mitotic and kinase activation functions of Dfp1/Him1 [1].	25.00	25.00	25.20	26.80	22.90	23.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.62	0.71	-4.34	21	135	2009-01-15 18:05:59	2006-01-19 16:09:07	5	5	127	16	103	138	0	126.30	36	19.62	CHANGED	sDl......Lt+A.+chtMKlWshEKL.pRhLpslsssppshpptp...........................tpspspssLopLLcsEKlaGsoDRDPpstRcDlpYF+..tPalYlaDlspph+PIhl+Ea...chhp.pct......aPph+sss.G+CPFls-	...........pDlL.p+A....+phshKIWuhEKl.pRhLpsltsspsstttt..................................................spspscssLspLLcsE+lhG.P.oDRDPpstpc-...lhaFK..uPalYlaDhppch+PlhlREY..........cls.pp...p-us..........WPph+sus.G+CPFlp-....................	0	26	57	89
+8464	PF08631	SPO22		Meiosis protein SPO22/ZIP4 like	Mistry J, Wood V	anon	manual	Family	SPO22/ZIP4 in yeast is a meiosis specific protein involved in sporulation [1].  It has been shown to regulate crossover distribution by promoting synaptonemal complex formation [3].	26.00	26.00	26.70	26.00	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.59	0.70	-5.32	19	164	2012-10-11 20:01:01	2006-01-20 08:51:43	5	8	135	0	108	177	0	243.10	19	29.98	CHANGED	phAhppsDhshApthhs+ucphh...hhssphstpLuchhYshGhphhppp.......shspuhphlpcuhchhph....schp..........pppsphppl+hpsLphLspshlpspstcsh.c.shchlphh...pp-hsp+.shhhLthchhhp.....httsthpc.Lpphltshshscsshphhlptht.hhspssttsstsl.hhlhs+hpssss...hhchtlhsphhhhstppp.ssp.hhcsltthls..hl.t.hspplosc.shsshhslLWspspphhptppYs.uhpahphuh.pthhh	........................uhtpschphAphhht+scthh....hhpsphh...t.pLsphhYshGhphhppp............phppuhhaLpp.uh-lh..............schp.............ptssphtph..phplLphLspsh...lphp..s...p.thtc..shphlphh...........pp-hs.p.psslhhLthclhhp..............tpthpc.Lhphlhp..h..s-.....sshphhlphhp.hhp.ps....t...t....sshth.hhlh.p+h.......pss....ts.....hhphh..llph.hhh.hppttp..s.p..lctl.................hh.....p.htp.lst......p.thpsh..hslLWpp..utp.aphppas.uhpahphu............................................................	0	24	53	85
+8465	PF08632	Zds_C	Zds1_C; 	Activator of mitotic machinery Cdc14 phosphatase activation C-term	Mistry J, Wood V	anon	Pfam-B_44907 (release 19.0)	Domain	This region of the Zds1 protein is critical for sporulation and has also been shown to suppress the calcium sensitivity of Zds1 deletions [1]. The C-terminal motif is common to both Zds1 and Zds2 proteins, both of which are putative interactors of Cdc55 and are required for the completion of mitotic exit and cytokinesis. They both contribute to timely Cdc14 activation during mitotic exit and are required downstream of separase to facilitate nucleolar Cdc14 release[2].	25.00	25.00	34.70	33.70	24.80	16.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.61	0.72	-4.57	11	139	2009-09-11 06:09:32	2006-01-20 16:03:23	5	2	123	0	104	153	0	52.40	63	5.56	CHANGED	ohSTVlMhDaRhPIpVERAIYRLSHLKLSNP+RsLRpQVLLSNFMYSYLNLVs	..........psslsh..sRFPIh.ERAIYRhuHlKLANP+RsLhpQVLLSNFMYuYLshVp.....	0	27	56	89
+8466	PF08633	Rox3		Rox3 mediator complex subunit	Mistry J, Wood V	anon	manual	Family	The mediator complex is part of the RNA polymerase II holoenzyme. Rox3 is a subunit of the mediator complex.	25.00	25.00	50.10	49.00	23.30	22.80	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.40	0.71	-3.98	13	111	2009-01-15 18:05:59	2006-01-25 16:29:35	5	2	107	0	82	105	0	192.60	34	59.81	CHANGED	YpsppPsPhpDLlslYGLsslAcpVARsss.DGpKhs+LRKSYKspIpcL..uG+Fssl.sc..Nt.GGlhshlh.............hps.utDlhpt.......hss-.hpcthpshshuhhpsPp.DW..spsVLuphcpShssthtNt......sshssschuhshsGotus.ss.stp.....t.spsKRph+Kpshu-toh.shuEth.DD...................hKRR++	......ap.stPsPppDLlslYGLsslAppVARssP.sGpKh..N+LRKSYKG+IpcL..uG+acs..ltpc......sssGGhhshhh...............................tps.sp-lhhs.........hssphhppth+shp.ht.G.hP.p..-a...psVLup.c.ohssthttt...........st.ssssh....s.h.shs...sst.t.s.ts..s.p..........t.sRscRth+KRshs-tuh.uauEua.DD....................hK+R+h...................................................	0	11	37	66
+8467	PF08634	Pet127		Mitochondrial protein Pet127	Mistry J, Wood V	anon	manual	Domain	Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localised to the mitochondrial membrane [1]. The Pet127 family is part of the PD-(D/E)XK nuclease superfamily [2] including a full set of active site residues.	25.00	25.00	54.20	46.70	18.70	21.50	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.87	0.70	-5.24	11	147	2012-10-11 20:44:44	2006-01-25 16:32:47	5	4	140	0	111	154	0	272.20	48	34.04	CHANGED	aloPScDppLlclAcctpKKYsuSTSSMTSlLSQlHaLLSsaRslsh..utlSpsF..s..sppssFopss+hPoSllLp.......hpsslauIDuDK....shDp-..ILSsLGHuLEphLTsccc-Ftphh.............ppphss.t.pphs-uY+YuphGcFlhRSQLDsaDs+LP.GoGsFDLKTRAVsuIRhDhsphpps...suYcIp+hhGphESaEREYaDLIRo.AhLKYSLQARIGcMDGIFVAYHNhS+IFGFQYlPLpEhDptlHuos-pt.....................................lAssEFphShplLpKlLc	.......................YlTuS+DpsLhplApcppKKYhGSTSSMTulLS+hHaLLSsaRslsh..stl..Sp.sF....s.tpspsF.Tpht+hPuulhL+...........hccGlYu.IDuDK....phDs.t......s...l.Lo.LG+ohEKhLThsp--Fc+Yphp...............................ppp.phsttt...pst..sEsYH.....Yoph.Gc.FlMRSQLDAY..DPRLP.GoG...hFDLKTRAVsuIRhDhpphcps...hGYpIcpth..GpaESFEREYaDhIRo.AhLKYSLQsRlG+MDGIFVAaHNhpRIFGFQYlsLsEhDhtlHGppctt...................................................lGDpEF+hSlpLhsclLp...................................	0	36	67	98
+8468	PF08635	ox_reductase_C		Putative oxidoreductase C terminal	Mistry J, Wood V	anon	manual	Family	This is the C terminal of a family of putative oxidoreductases.	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.74	6	39	2012-10-02 13:21:44	2006-01-26 11:15:45	5	2	28	0	27	83	46	132.10	46	33.14	CHANGED	RYLpsVQKMKpIlcENNLpVMuTsARYssAYEHssKhsWWsKSlssGPlVEQuTHFCDLSRYFGGDVDlsTlpu+ulEWaE.sG+LoKlPlDESs.IP--pRIPRhTuAoWKYcSGAVGshpHuluLQGssYuTELEVhADGY	........................................RYLpsVQphKpllc-ssl.p.lhssh.A.RYs................sA..YtthsKssWW.s.K.u.h.s..s..G.PlVEQuTHFsDLuRYFGG.-.V-.hsoVhu+ulch.-ps...G.pLsKls..lDEot..Is.-pRlPRhTsAsWKacoGAVGshhHshsLQGpsYsspl-VhADGa.............................................................	0	19	24	27
+8469	PF08636	Pkr1		ER protein Pkr1	Mistry J, Wood V	anon	manual	Family	Pkr1 has been identified as an ER protein of unknown function.	25.00	25.00	25.40	25.00	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.58	0.72	-3.92	20	147	2009-01-15 18:05:59	2006-01-26 12:00:54	5	7	140	0	110	140	0	74.60	44	37.83	CHANGED	Mus.FlpsLWpSIFTPGsTPsLllATpsoFAAL.llLlsLlhsTt.SIHFlhL.lLuusLWholsWFltELppschp	..............Mus.FhtcLWpSIFTPGs..T..P.....s.....LllATssoFuAL.lsLhsLlhsTh..SIHFllL.hlssuLWholsWFhpELptsp..........	0	32	62	95
+8470	PF08637	NCA2		ATP synthase regulation protein NCA2	Mistry J, Wood V	anon	Pfam-B_15813 (release 19.0)	Family	NCA2 has been shown to be required for the regulation of ATP synthase subunits Atp6p and Atp8p in Saccharomyces cerevisiae [1].	20.60	20.60	20.90	23.80	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.85	0.70	-5.52	13	207	2009-09-14 08:31:22	2006-01-26 13:06:51	5	3	172	0	151	206	5	263.60	28	41.54	CHANGED	slL.hhhht..olhtlhps+ppIhpal+.ssh-slpuFhpNWVhpPlpplhcTlRasp.sSplulhSpcoLpS-h-SLpRMll-FstDppssss.......lshpplpsc....lcpGDLT.......lhchYEppl+pPlKslloGsLlRoLLIQlQKsKVDsplAlsGID+lLKSQQLlFulVuluPullIlYshhphLpphltstsphupst+hp..phpl....oLsslE.RlL.......shstp...................tt..ss-hsphph......GLLll-lpsL+phuspll..........PtshpcEW...lcDLc-Lsssshss.ss+LsllpRIa+sY	.....................................................hh...........t..h....hhpppt.pl..palp.phhpshhsFhhsWlhpPlpplhssl+cs...psphulhuppoLpu-hp......SLcRMll-Fst-p.t...................ph.ptlppp...................l.cpGDlo.................lhctYEp-l+p.P.lpshl.pGcLlRuLLIQ.................lQKsKVDlphAhsGIDplL+SQcLs....F..uhluhsPulll....hthh..ph....lpt..hhttt.pth.ptttc...h...t....ph................Lpsl-.R.lL.......p.t.........................................................................ttts..s.hph.................GLLlhplph...Lhphspthh.............................s..t.p.h..tp-a...hcDlp-L.....ps...t.h.sh..ttphpslpRlhhsY.....................................................................	0	52	93	130
+8471	PF08638	Med14	MED14; 	Mediator complex subunit MED14	Mistry J, Wood V	anon	Pfam-B_13303 (release 19.0)	Family	Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation [2][3].  This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator [5].	19.90	19.90	20.30	19.90	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.25	0.71	-5.06	29	300	2009-01-15 18:05:59	2006-01-27 09:41:35	6	6	249	0	227	324	1	186.60	31	16.21	CHANGED	shhPLutLlpphsQpsap-LsslhcpLsp.......................................t.pspsshpKKhclLpahhthRspFlKLhVLs+Wu+pup..cVs+hIDlhsal+tpphhasssh.tLssh.+psLstA+lPNsDLhTALEVLspG...phsshsshs..alssss............loscphLcpLpcLNpllphRLs.l..hpplPtph.psYcI+cGRVTFpVssEFElsLolss-s	.............................hsLuhLlphhhppsap-Lp.LhchLsp...........................................psshc+KhpllpastppRp.Fl+LlsLsKWuppus.......pV.p.+hh.p.l..sal.c.ppph.haspshppLtph..+cs.....L.spA+lPshclssAl-VLooG..........+lPsh.c..p..t.....hls.sss......................lo...pct..h.....psLp.cLNpllphRLs.........ps..plP..ph..pshp.....l...............tsGRVpFpVtsEFElsLTlhsc...............................................................	0	76	124	189
+8472	PF08639	SLD3		DNA replication regulator SLD3	Mistry J, Wood V	anon	manual	Family	The SLD3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication [2].	20.00	20.00	20.10	20.30	19.10	19.40	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.74	0.70	-5.86	24	128	2009-01-15 18:05:59	2006-01-27 10:36:39	5	2	119	0	98	134	0	463.60	21	59.51	CHANGED	-.h-hlcppYhpuLYho+TulAYFsKusLuRsRshhpsspsss..................p.lhshl+phlLsscphDp+Ycts....hpshhlhtsss-s...tt.pt+pp+s.pc..pchucsthhstt.thhtp.ahtp..s.pt...tp.st........pchcchlusL+lREsQLQllLlLEhl........uL......hshssEtppstppsstsh.pp...pp+sppccKtpclsh.......................................................hL-lalDRLCIWcslpsscshhsppsps.stt....................spchppssl+cFCspVllPaausRLPchschIs+KLs...sshthsPhpppps..........ptshscsusssc.........cp.....sspppppcohp+Vho-ppt.....ttttttssL.RStTsss....hccEop.shh.sh.spsp........usl.ps+phppRplslsshutpcpsch+c.thh...cpcLcsuhsulcKss+tlsucsl.spsucK+st..................hhpslQlhATPt.ssRpcs.h........................................................s..p.t....s..................................ptspssVptTPp+	...............................................................................................................p.hp.lpppYhpsLY.........psslAYFsKusLsRh+shhp.s.pt...................t.hhphhpphllshtphDt+..acpp....htthhhhhtpspt......t..php+t.pp.......phscss..............t.t....t......................pphpphlstL+hREsQLQllLlLEll...........tL..........hth.ttc.....p.....htttp.t..t........tpp..pp.cpcpppshsh.............................................................hL-lhlDRLsIWcslttschh..tt.t....tt............................ppspp-tlpsFss-VllPaast+LPchschlpcKLt...ssht.ss.ptptp...........pptspspsssshp.......................p..................s.tpsppoh.p+shsscp................t..tth.sL.+otosss...........tlcpEsp..p..h.......s...spsc..............................usl.p.+h.hp.pRphsl...sshs.....p..tpp.c..........ppht.h............ctpLp.sAhsshp+ssRtl.sscsh..scssc++tt.............................................................s.tpslQVhATPt.tpRh.psh..........................................................................s....................................................................................................lttTP....................................................................................................................................................................................................................................	2	24	51	84
+8473	PF08640	U3_assoc_6		U3 small nucleolar RNA-associated protein 6	Mistry J, Wood V	anon	Pfam-B_8720 (release 19.0)	Family	This is a family of U3 nucleolar RNA-associated proteins which are involved in nucleolar processing of pre-18S ribosomal RNA [1].	20.90	20.90	20.90	21.30	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.84	0.72	-4.22	34	307	2009-09-11 15:26:11	2006-01-30 13:06:58	6	3	277	0	221	297	2	82.60	32	15.23	CHANGED	LEptlPELc-LccptlFo+pElppIl++RocaEa+LppRssphp..DFlpYlpYEhsL-cLhpKRtp+lt.......pppptt-auh.p..RI	...........LEphlPELcclccptlFo+..sEIppIl++RscaEa+lpp+ssphp...DalpYlpYEhsLcpLhp+Rpp+lth.......ht.p..p.sh......................................	1	79	124	183
+8474	PF08641	Mis14		Kinetochore protein Mis14 like	Mistry J, Wood V	anon	manual	Family	Mis14 is a kinetochore protein which is known to be recruited to kinetochores independently of CENP-A [1].	21.20	21.20	21.70	22.70	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.82	0.71	-4.11	14	172	2009-01-15 18:05:59	2006-01-30 13:18:49	7	2	152	0	115	161	0	138.70	20	55.64	CHANGED	phuppulplssh-hpu.....sl...hslss.s..pspchEPaDh-LstplpplapphEctsVcVAphR+ssPpphtctYs.......cpppphLpp......h-pcl.............s...t.p.s.t.t-sDtpsp.st.tpp..pthhp......htpuhsplhphp.sl	..............................................tt.slp.sths..hps.............sl..................hsh.sts.......pppchEP..aDsclptpltpLhsph--lhlclAphR+phPt+lscsht.......cstpchLpp........................hcttl................s.t.t.p.p....t......t.s...tt...........t................................................................................................	0	18	45	84
+8475	PF08642	Rxt3		Histone deacetylation protein Rxt3	Mistry J, Wood V	anon	manual	Family	Rxt3 has been shown in yeast to be required for histone deacetylation [1].	29.90	29.90	30.30	30.10	29.50	29.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.73	0.71	-3.84	13	171	2012-10-01 19:31:27	2006-01-30 14:35:38	5	3	148	0	130	169	2	109.70	34	14.56	CHANGED	lsl+Istcal................ptth....cs.hstpRplWG..TDIYTDDSDllhlLhHsGhhpsshs.p.......................+pos.sh.spspsh...us.......s.Ph.tDLcVslLlLPpLp+YtSshR.GIpSRsWs	............................hpl+lst.cl................ssth...........ppchstpptLWG..T-lYTDDSDl.lAshhHsGahpsp..hs.s...............................................................t...p......t.............tt...............s.......DLplplLlLPpL.cY.ushh.ulpSRtW.......................	0	32	76	111
+8476	PF08643	DUF1776		Fungal family of unknown function (DUF1776)	Mistry J, Groocock L	anon	manual	Family	This is a fungal family of unknown function.  One of the proteins in this family Swiss:P32792 has been localised to the mitochondria [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.85	0.70	-5.28	15	135	2012-10-10 17:06:42	2006-01-30 15:01:01	5	4	126	0	99	2683	945	275.30	30	64.76	CHANGED	ARp-VVllsGSss-PlTRslAhDL-RRGFIValsspstc-tphlcscs.p.-.IcsLslsp.......ts.shpsslscFtphlppP.hshsssp.HhLpLpullllPSLsa.ssGPltsIssuoass.lss+lLs.l.lsspullPLlpt...................ppsplIllsPoIhuuLshPaHuPEslhsuslpshhpsLscElp....hsIsVspl+LGslslu...............sssSssphuslssS-....hhsWstph+sLYussasth.tpt.shtth.........RGoolRcLaphlaDhl.sp...............sssllYsGpGuplYsa.....lucalPculls	.............................................................................................................uRp-lV.llh.G.u.sp-PlsRsluhDLE.RRG.FIV.al....s...sp....ss.-..-.........p....hl...cs.p....s.....p.D....Ics.Lhl-.........ps.phtsslpph.tphlpp........s..................sh.s.s..h..........s...........p......h.....p...Lp.u...l....l...h.lP..s.Lp...Y...so.GP.l....tsI..s.s.s.s..aschlN...o+lLhsl.hshpshLPLLpt......................................................pp.s..pl...l..lh.s.P...S.I......o.uL.s.h......P.a.p.u..s.E.s...h.s....s...s...u..l..s....uhhpsLppELp............slsVsplcL.G....sl..c..lu........................tt...t..p.....t.h..t.p.hssoc................W...........tt...+s.lYu...ssaht..hp.t..t...sh.............pGo.s.....h..R..p...L.a..hlhDhlts.........................hsss.h.h.s..G..p..G.u.hhYsh.....luphhPtshl.t...........................................................................................	0	22	52	81
+8477	PF08644	SPT16		FACT complex subunit (SPT16/CDC68)	Mistry J, Wood V	anon	Pfam-B_4478 (release 19.0)	Family	Proteins in this family are subunits the FACT complex.  The FACT complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin [2].	25.00	25.00	31.10	29.40	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.00	0.71	-4.37	32	353	2009-01-15 18:05:59	2006-01-30 17:00:05	6	13	294	0	255	354	4	151.60	43	15.34	CHANGED	IaVDpcppolllPIhGthVPFHlsTlKNsSpspEush.sa.lRINFpsP..Gsts..sppct....hps.ssshFlKEloaRSpcsc+...........hsplhctIppLpKphppR...EsEc+chtsllp..Q-+Lhl.ps.....pcsh..pLpslalRPsh.su....++hsGsLEhHpNGhRY	.....IaVDpKtpoVllPIhGhsVPFHIsTIKNsSp.osEG-a..s..............Y.LRINFhsP...Gssh...u+p-sts......aps..ssApF...l+plTaRSpcscc...........hspshptIp-lpKchtpR...............EtEc..+EtpslVc..Q-cLlhsps.....+pss.......+L.pDl.alRPsh..ss......KRhsGsLEhHpNGhRY..............	0	90	143	212
+8478	PF08645	PNK3P		Polynucleotide kinase 3 phosphatase	Mistry J, Wood V	anon	Pfam-B_6220 (release 19.0)	Family	Polynucleotide kinase 3 phosphatases play a role in the repair of single breaks in DNA induced by DNA-damaging agents such as gamma radiation and camptothecin [3]. 	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.07	0.71	-4.79	32	1136	2012-10-03 04:19:28	2006-01-31 09:22:57	6	29	976	20	329	2109	716	164.20	32	45.94	CHANGED	Kl..AuFDLDuTLIpo+S.Gtsasp.s..........ssDWpa...h..p......l.p+LppL.hp-s...........YplVIFoNQuGlst..............spt....shpsappKlpslhcpl....slP.....ltlasAsp.c..........................................D.....haRKPpsGMWphhtcchsp.....h.lshp..pS...aaVGDAAGR..........................................................ppDaSssDttFAhNlGlpFhTPEEaF	...............................................................hhhhDhDGTLIppss...pp..a..s...s...........t.Dh..h..h...hcss................VhspLh....cL..pctG............Y+lVhlTNQcGlGo................thspt...ch-s..+...s...h....h..h..p..Ih..p.u...........Glp.................l..p..l..a..h...s.s..c...c........................................................................................s..........pCRKPK.suhlc.c.alpc.t....................h.Dht....pS............ahIGD.....thsc........................................................................................................ht..hh...............................................................................................................	0	129	192	276
+8479	PF08646	Rep_fac-A_C		Replication factor-A C terminal domain	Mistry J, Wood v	anon	Pfam-B_3457 (release 19.0)	Family	This domain is found at the C terminal of replication factor A. Replication factor A (RPA) binds single-stranded DNA and is involved in replication, repair, and recombination of DNA [1].	24.20	24.20	24.30	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.04	0.71	-4.49	33	798	2009-01-15 18:05:59	2006-01-31 09:34:27	5	48	363	3	503	733	13	135.40	23	24.30	CHANGED	aaol+Aslsal.....Kp-.shhYsACsp............sCNKKVs-p.ss...........Gp...........WRCEKCspsaspspYRYllshplsDpTGphWlTsFsEsAcplh.GhoAsELtcl+c....pssppasplhpphphppahF+l+sKp-oYs......-EpRl+hTVhslp...slcapt-ucpL	................................................hphhuslh.hl.....c..pc...s.......h..hY..ACs....................pC.s.K..K..Vhpp..ts........uh.....................apC...c.+..C..s.....p..ph...s..p...s.p..aRYh..lsh..plsDto.u....p.hhlosF..s..-s..ucplh..Ghs.A.sp.L..h..p.hpp.............ps..pt..h.tphh.p.ph....hp.pa.a..+...hps.p....ct.at......tp.+...p...h.h.t...................................................................	0	138	269	387
+8480	PF08647	BRE1		BRE1 E3 ubiquitin ligase	Mistry J, Wood V	anon	Pfam-B_35727 (release 19.0)	Family	BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions [1].	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.04	0.72	-4.01	20	193	2009-01-15 18:05:59	2006-01-31 13:57:30	6	7	177	0	138	205	0	97.20	30	12.53	CHANGED	LppELsslcpAacchpphspcKht-hpshEpphs+LssEKsKADQKYFAAM+s+DulpsEhKpLppphsKss-llppLp-....hEpphppplpshcKpl	....LppELsphppuacchpphsppKht-hsshEp+ht+LpsE.................KsKADQKYFuuh+st-shpsEl+pLptphsKss-llppLc-....sEsphpptlpshEKph.......................................................	0	39	71	111
+8481	PF08648	DUF1777		Protein of unknown function (DUF1777)	Mistry J, Wood V	anon	manual	Family	This is a family of eukaryotic proteins of unknown function. Some of the proteins in this family are putative nucleic acid binding proteins.	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.10	0.71	-12.04	0.71	-4.54	7	315	2009-09-11 17:09:29	2006-01-31 14:03:37	7	31	236	0	237	303	3	165.60	29	60.66	CHANGED	MuRSRS............Ro..c+cRRcsc.spsR-.................ccRcR-RsRSR-.RDR....+RsRsR..s.+.R.pRsRSPcR................cRSpSpS..Rc+-...Rccpcc+csc.cP......+t+.hQ..........................IscpcL-.Gcsc-ph..................-MMK.hMGF.ssFDTTKGKKVsGs.DsusVplppKR+YRQYMNR+GGFNRP..LDFhs	..............................................................................................................................Rp...ppp+.p...ptc..spp.Rc.....................p.cRc+.p.Rs...R.sR.p.....R-c............cR.s..Rp...+......s..p...+....p..Rs.+Ssp+................................................................pcsp....s...s.....t..cp.pp......Rp..p.....ppppp.pp...p........................p..p...........................................................................................................pp..t.c..hp...st........st.--h.....................................c..Mh..+.hMGF..suFsoTKsK+V...............Gs.....s..s.........u....l..p..h...pK..ppYRQYMNRpGGFNRPL....s....................................................................................................................	0	86	137	191
+8482	PF08649	DASH_Dad1		DASH complex subunit Dad1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4]. Throughout the cell cycle Dad1 remains bound to kinetochores throughout the cell cycle and its association is dependent on the Mis6 and Mal2 [5].	27.50	27.50	27.70	27.70	27.00	27.40	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.67	0.72	-4.27	11	108	2009-09-11 11:16:04	2006-01-31 17:20:58	5	3	106	0	80	107	0	57.10	48	38.23	CHANGED	pYFpcQR-lLlQEIosoh-sllsNLNsLN+SLEpSluVG+EF-sVucLWppFYsulsp	............paFEpQR-hLlpEIu.....tohEpVLsNlNpLNRSLEulI.........uVGpEFsSVpuLWSpFpssMt.t.................	0	21	45	73
+8483	PF08650	DASH_Dad4		DASH complex subunit Dad4	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	20.70	20.70	20.90	20.70	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.30	0.72	-4.07	8	105	2009-01-15 18:05:59	2006-01-31 17:22:25	5	6	102	0	82	101	1	67.70	50	63.19	CHANGED	M.ENPaEcVQsslLuRIIuNVE+LNpSVspLNQpLcclNp+N+NLElMuQhCENYpcuVpFNLEATGs+KsPL	........MEsPHEppQshLLuRIIsNVE+LNEulshlN+sLp-INhpNhNl.ElluQ.....MacNYpsNV.FpLE..ATpsh+.P.t..............	2	23	46	70
+8484	PF08651	DASH_Duo1		DASH complex subunit Duo1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	25.00	25.00	25.90	27.00	23.10	24.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.47	0.72	-4.40	16	126	2009-01-15 18:05:59	2006-01-31 17:37:22	5	3	123	0	95	124	0	76.90	39	32.01	CHANGED	tuLp+EL-pLc+INtlIEslhtsLcsup.sphpplpcoscusspLLspWhpILSQTpaspcLl.sssWpGtsp.DstshE	......uLpcELcslRpINpsIEullsoLcpup.sNhpsVscolpsussLLsoWo+ILSQTEasp+LlhsPsWpGssp.Dhhc.E.............	0	23	48	79
+8485	PF08652	RAI1		RAI1 like PD-(D/E)XK nuclease	Mistry J, Wood V	anon	Pfam-B_13095 (release 19.0)	Family	RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease [1].  It is required for 5.8S rRNA processing [1]. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteristic to the PD-(D/E)XK nuclease superfamily [2].	19.90	19.90	20.40	19.90	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.19	0.72	-4.19	31	357	2012-10-11 20:44:44	2006-02-01 09:27:35	6	7	232	4	253	347	1	69.10	34	17.75	CHANGED	VDslhc.tpsps..t.....................ppYVELKTopth.....ps.p...phpsFc+..KLhKhWsQSFLlGls+IlhGFRDcpthLpsl	.........................................hDsh.s..t.tt..............................tpaVELKTotth........ts.p......phpsF.c.........R...KLLKaWhQSFLlGlscIlsGFR-sc.Ghlpp.h..............	0	79	137	212
+8486	PF08653	DASH_Dam1		DASH complex subunit Dam1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4]. 	21.40	21.40	21.50	21.90	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.82	0.72	-4.20	16	130	2009-01-15 18:05:59	2006-02-01 09:35:50	5	2	126	0	97	128	0	57.70	51	23.74	CHANGED	phlhsphpcLuDuhtsLDtNhscLphIH-uLss.FNESFuoaLYGLphNuWCVDFPssP	.......s.hlpPtFuELuDuhs-L-uNhh+LphhHESLuc.FNESFASFLYGLsMNAaCVDFPcuP........	0	26	55	85
+8487	PF08654	DASH_Dad2		DASH complex subunit Dad2	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	20.70	20.70	20.80	21.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.33	0.72	-4.02	18	132	2009-01-15 18:05:59	2006-02-01 09:47:46	5	3	126	0	100	127	0	97.40	34	64.41	CHANGED	sltt+I.spK+AEL-sL+pl+chossLssQh-tLppKlushsDGTEuVAsVLuNWpsVl+uIShA....Shtlh+hsptchppst..........................PLPpsLVRI.sls	.......h...t+ltpK+tEL-sLppL+clSssLssQh-tLpp+Lsshs-GsEuVAtVhuNWp.sVlpuIshA....Shplhphspt..s.p.t......................................sLPpsLVRI.h.........................	0	29	57	89
+8488	PF08655	DASH_Ask1		DASH complex subunit Ask1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4]. 	20.70	20.70	20.80	21.20	19.60	20.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.00	0.72	-4.15	15	126	2009-01-15 18:05:59	2006-02-01 09:56:55	5	3	124	0	95	122	0	64.40	50	14.44	CHANGED	LE+L-Q-ITLsLQ.-IDpNlSpsaplITpcIlPhlpcYupsocclh-uu..pFWKpFFEpSANVpLsua	..........LE+L-QpITLsLQ.-IDpNFS+uH+IlTssIlPhVcpYucpScsVW-uo.....+FWKpFFEsSANVsLouY.......	0	26	52	79
+8489	PF08656	DASH_Dad3		DASH complex subunit Dad3	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	21.80	21.80	22.40	22.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.65	0.72	-4.28	17	110	2009-01-15 18:05:59	2006-02-01 12:45:57	5	2	109	0	83	108	0	79.10	45	62.12	CHANGED	LSPLEpplLpcYppLussLpp.....LsspLppL............ossssp......................tlLcsLRpLEhKhuLVhTLhKuSVYSllLppp.spptcssp	.........LoPLEQEVL-EYp+Lspshpp.....LussLppL.............ussPss..........................plLDsLRpLERKhuLVhTLLKASVYSIVLQQphtttt....ts.................	0	18	44	71
+8490	PF08657	DASH_Spc34		DASH complex subunit Spc34 	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4].	25.30	25.30	29.10	26.40	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.60	0.70	-4.72	21	142	2009-09-10 21:43:34	2006-02-01 13:01:21	5	3	120	0	104	127	0	205.80	29	85.12	CHANGED	LsppL-pIptSscuIsoL.F...ssPtIFTNAllpsp..s.........ITsLIRDs-scE.puLaphssssp..t..t.................................................tppppspc......ctshhp..............spsts.shhsphhsupsppppst..hsh..Gu.hh.p...............ht-hsl-hlLcshppLsshY.Phs..........usp-+lssLppcapplpssltpLEpcltcQpppLcpht.spppt.s.........t...................ss-c.Ic+EppEIccLEpchpplc	..............................LptpL-pIphuspuIssL.......F..........PPtIFsNAlLtst.s...........ITpLIRDspscE..psLFplsss....t.......................................................tpt.tt......pthhh................tsth....thhs.th...tspt.hpp.h..huh..Gs.hhtp.p.......................ht-hsh-llLcshp.LsslY.Pls...........shpp+lspLppcapplpsplt.hEtcltppptpLpphs..t..ttt..................................scc.lc+E.pEIcpLEtchppL...............................................	0	24	55	88
+8491	PF08658	Rad54_N		Rad54 N terminal	Mistry J, Wood V	anon	Pfam-B_26946 (release 19.0)	Family	This is the N terminal of the DNA repair protein Rad54 [1].	20.20	20.20	20.30	21.50	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.57	0.71	-4.55	24	204	2009-01-15 18:05:59	2006-02-01 13:08:54	5	12	187	1	144	211	0	167.20	29	20.79	CHANGED	s.p.hssspShs+L..sKPFKsPh....................Suosspssc+PuRKRR..pVsYu.....ssss-ss-t.s-psh.................pscc+hALusRc...............sphsshphccp-ssh++sFoVPl...hspptssYssp+.PsPoLGhRptsshss+PLHDPouEFAIVLYDPTVDstsp............ccpptpp............cpcspcpp.c.................lcs.shh...HK..SLAEILG.....l....KKKhp.chPcV	.................................................................................t........................................................Rptp....hsYt....................................h........................................ptth.uL.sp...........................hhs.s...p.tt..hcplhp+sFpVPl.....p..s.s...Y.sspt..ss.sLGh+psshhls+PLHDPhsEaAIVLYDP.olDs...............................................................t.....................................................................p...........p+.oLtclLG................p.pt...thP.l.................................	0	40	71	115
+8492	PF08659	KR		KR domain	Hoof I, Finn RD	anon	Hoof I	Family	This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group [1].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.88	0.71	-4.62	85	6808	2012-10-10 17:06:42	2006-02-01 14:48:52	5	1300	1204	23	2532	84357	23197	179.60	32	8.62	CHANGED	GoYLlTGGhGG...LGttlAcaLs.c....+G.AccLlLsuRs...............sssspsp.....t............hl....ppLps.h.Gs....plphhssD..luctsslppl...lsplptph...sslcGVlHuAullp.Ds.hltphospchppVlusKVpGshsLcchhts.......psLDFFllaSSluu.lhGss..GQusYAAANuFLDAhAptRcspGhs......uhSlsWGhWtss	...................................................................................ush.LlT..G....G.......h....G...u.......lG..h...h.......l.A...........c.a..L....s....p...........c....G....s.....p.........c...........l.....l......L.....h..uRp...................................................................s.s.t..s.t..........t..................................................hl.......p..c....L....p...t......h.....G..s.....................p.l.....p.....h................h...s.........s....D......l....u....D......t........s........s...........l........t....t....l.............l......s......p.......l............t...........t............ph.......................s........l.................s.......G.......V.......l...H.......u...........A...........G.................l................l.................c........D................u.........h................l............t................s................h............o........................c.........p.........h.........p.........p.........V.........h.........t.............s..........K........l...........p........G........u...........h.........p.........L......c.....c.....h.....s.ts.............................ts.L......c.......h.........F.....l.......l...F....S.....S...........h...u....u........l....h.....G........s.....s............G....Q........u......s......Y.......A....A....A....N.....u....a....L....D....u....l....A....p....t....R.....+.....s....p....G..h.s.......................uh.o.l.sWGhWtp.s......................................................................................................................................	0	634	1473	2142
+8493	PF08660	Alg14		Oligosaccharide biosynthesis protein Alg14 like	Mistry J, Wood V	anon	Pfam-B_12992 (release 19.0)	Family	Alg14 is involved dolichol-linked oligosaccharide biosynthesis and anchors the catalytic subunit Alg13 to the ER membrane [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.22	0.71	-4.26	35	618	2012-10-03 16:42:30	2006-02-01 15:15:23	6	10	514	0	296	1021	447	156.50	28	77.72	CHANGED	lhllhGSGGHTuEMhcLlpth...........pshcpahlutsDshStpphp.....ht.p................hhplsRuRpVtpuhhpo...lhoslhsh.htuhhll........h+.+...........PclllsNGPGssVPlshhuhLhthhh..............................ps+llYlEShuRVpsLSLSG+lLh..h.uDhFlVQW.pLpcp.....Y.s+upY...h.Ghl	.......................................................................hllhuS.GGHhschhtLhthh...............p.cpahls.scp.utp............................................................................hhph......+...s.t...p.l.t.ps..h..hps......lhsh....l....hsh.hhuhhll...........h+..+................................PDlllssGsusslPhhhhuhlh.................................................................ts+hlYl.EShsRlpphSLoGKllh...l..sDh.FlVQW.phtch......Y...s+u..h.h.G......................................................	0	99	171	240
+8494	PF08661	Rep_fac-A_3		Replication factor A protein 3	Mistry J, Wood V	anon	manual	Family	Replication factor A is involved in eukaryotic DNA replication, recombination and repair.	23.50	23.20	23.70	24.40	23.40	23.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.26	0.72	-4.15	22	305	2012-10-03 20:18:03	2006-02-01 15:55:35	6	3	260	14	216	294	2	107.40	23	87.79	CHANGED	Ms....tsssRlssuhLppa........hupsVRllu+Vpphc..uphhlhpsssst............slplphssshph..sshl.EllGpsssss......slcshshh.-hup..shDhshhsplhplspch..pha	................t.....sssRlssshL..s..p..a.........huc.sVpllG+V..pp..lc...Gp..thhlsss.-st............sls.lpl........s....p.s.h..ph...t..h.s.s...hl.EllGpV..ssst...............slphhtht..-hus...shDhphhspllcls.p.ch..tha...........................................	0	71	118	178
+8495	PF08662	eIF2A		Eukaryotic translation initiation factor eIF2A	Mistry J, Wood V	anon	Pfam-B_7957 (release 19.0)	Family	This is a family of eukaryotic translation initiation factors.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.13	0.71	-4.60	22	1027	2012-10-05 17:30:43	2006-02-01 16:42:42	6	49	446	0	624	2639	160	177.20	24	29.09	CHANGED	KsFFpu-csphhWNppGssLLlhss...TchDKospSYYGppsLahl......thsss.sshlpLspcGs.IaDhsWsPpucEFsVlaG..hMPu.csshash.....c....sssltshspps+NolhasPpG+hlllAGFGNLs.Gpl-h.aDhp..phcpluphcssssohs-WsPsGcallTAoTuPRlRl-NGaKIWpasGpLlaphph...sELapl	.........................................................................................shhpsspsphhW..ptt..uphlhhhsp..........ch.s..p.s.t.....p........shh..s...p.............plah..h......................t.t.t..t.h......s....t.h.lp..l........p.c.p.t.s.....l.h.s..h..sW.............p...P.............s............u........pc.......F....s......l.....l............h...........G.............h.s.............t.........pl..........sha.sh........................c..................sp..h...l...t...s...h...t....p...p......s.....t.....N.......s.......l....h...a....S..P.p.G........p...h.l.l.l.....u.u......h....t..............s....h...p........G.p..l.p....h...aD...........h.............p.................p..............h..........p.....h................h..............s.........p...h........c.....t.......................s....s...........o....s..h...p......Ws..P.sG.+......al.h.....o.....u.....s...s.........s........................p...h....p...h...p...N.........G.hpla.p.h.p.G.t..h.p..h....tth.....................................................................................	0	222	347	511
+8496	PF08663	HalX		HalX domain	Bateman A, Galperin M	anon	Galperin M	Domain	HalX is a domain of unknown function, previously (mis)annotated as HoxA-like transcriptional regulator.	23.30	23.30	23.60	23.60	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.31	0.72	-3.99	13	74	2009-01-15 18:05:59	2006-03-07 15:01:53	5	4	22	0	47	76	0	69.40	28	34.79	CHANGED	lsRs-YD-plpEhaALsSKpAsLEupKssspLpsS-cYscLp-Rl-pLcscl-ssssphssp.Dacuhhpsh	........pRspY-cplpEhauLsuK+AsLEspKsps-Lpcs-cYpcLpsRlccLcspl-psh.sph..psp.Dh.thh..................	0	3	32	47
+8497	PF08664	YcbB		YcbB domain	Bateman A, Galperin M	anon	Galperin M	Domain	YcbB is a DNA-binding domain [1].	25.00	25.00	26.10	75.80	20.20	24.30	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.59	0.71	-4.37	21	318	2009-01-15 18:05:59	2006-03-07 15:12:28	5	2	240	0	48	218	1	134.50	43	44.99	CHANGED	cphphlLu-LGIsGEuGucDllpllphlhcppps.s.......sLKplFpcluppc.....t..chp+EhKAhEQRIRRAlhpuLsplAuLGlsDasNspFcpYAsphFDFpsV+pcMpclpscsst...pu+lNlKKFlpsL	........s.ph+aLLSELGIuGEsGS+DLlshl-YLhppEpspo.....thPuLK-lFpplst++Ls...s.ts-lc+phKAuEQRIRRAIhpuLsHLASLGLTDFpNPKFEsYAs+FFDFssVR++MsElppcpst.........tsRIssKKFIQVL.	0	21	37	41
+8498	PF08665	PglZ		PglZ domain	Bateman A, Galperin M	anon	Galperin M	Domain	This family is a member of the Alkaline phosphatase clan.	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.19	0.71	-4.61	16	530	2012-10-03 20:55:17	2006-03-07 15:56:20	7	2	502	0	158	551	302	178.40	25	24.53	CHANGED	cRVhVIlSDAhRaEhupELtphLNpcsphps-l..p.......shhulLPSYTpLGMAALLPHctltat..tstsVhVDGpsspuhtpRptILtphh......uhAhptc-lhshspccsR-......hl+spcllYlYHNpIDuhGD.....+tsoEppsF-Ascpslp........pLpcLlphlhsp.sGsplhlTADHGFlapcssl	........................................................................+lhlIlsDuhRY-ht.ppL.tp.p...l.s.p..p.p...p..h.phch....p..................shhuhLPohTphuhs.Alhs.....s..p.....h......p...h...........t....t...t.sp..h..hs..-.....s.p.p.p.p.s.h.s.....t.+.p..p..h.Lpt...........................shshp..hc..clhs.h.pp..sctpp.........hhp..sp...c...llhlh...a.NtI..Dt.huc.........p.h.p.Et.....t.s..hc......us.......h.....cul.s...........tLtcllppltst....s.h.c.lllTuDHGalhppp..h..................................................	0	72	122	146
+8499	PF08666	SAF		SAF domain	Bateman A, Lakshminarayan I	anon	Lakshminarayan I	Domain	This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.85	0.72	-3.57	169	4935	2012-10-01 20:51:14	2006-03-07 16:09:21	7	24	2605	28	1282	4640	2751	65.60	23	18.28	CHANGED	psllluscs..lttGphl.........sspslphtpss...h.huhhspt................hspllG.....thstpslttGphlphsplp	..................................plslA.hp-..lttGphl.....................stps..lp..h..t..p..s..s....hthultsht............................................aspl.l.G.......hAtpslttGphlp.ptl...............................................	0	427	825	1065
+8500	PF08667	BetR		BetR domain	Bateman A, Galperin M	anon	Galperin M	Domain	This family includes an N-terminal helix-turn-helix domain.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.80	0.71	-4.26	6	180	2012-10-04 14:01:12	2006-03-07 16:15:43	5	3	131	0	45	208	4	118.90	32	49.44	CHANGED	sschlsss+lRcLLs+pGIucRp+sohIsplLGLShSsupRKL+GuhPWsLuQLp+lAptaGhPsu.LL....-spGhsP............ss-hpDAlLshpspchpC+............AhI...uspusupspspFVAhp...pspWhVht+scs.-p....csYsVchl-lps	......................................s..phhhup+V+cLhs+pGIs.Rpp.s.o.plsclLsLSaSsu.pRK.L+.GpsPWoLuQlpclActaG.s...supLh.....ssp......................pAhh..t..ph.Ch............hhl...st...s.t..s.h.A.p......W.lh.hpth..t.....ha.sch....................................................................................................................	0	5	12	28
+8501	PF08668	HDOD		HDOD domain	Bateman A, Galperin M	anon	Galperin M	Domain	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.07	0.71	-5.03	57	3180	2012-10-01 20:28:14	2006-03-07 17:06:09	7	42	890	11	1179	4044	485	178.50	20	48.05	CHANGED	LPslPslhhclhphl.psPssshsclAclIspDssLoA+lL+luNSshau..hsppls.olppAls.hLGhpplpsLsluhulhphhpst......hhchpthWc+SltsuhhuctlApth......shtp.s..-csahuGLLHDlGclhlhphhscthttlhphhtttt..shhpsEcchhGhsHsp.........lGuhLhcpWphPttlscslthH+ps	....................................................P.hsthhhclhphh...s..p..s..s.s..s.h..p........clscllppDssLosclL+h..s.N....S....s....has.........hs..p.......p......ls....ol..p.p...Als.hL..Ghpp..l..c.s..l.l.h.s.h..s.l..t.p.hhptts...............h....pph.a.p..p.....uh.t.....s.At.h.s.p.h..l.u.p.p.h................sh..tt.............-p.sa...h...s..GLlpslG.h.h.h.h.t........h........t.....h.................h...................................................................h......t......t..h..h......t.h.......h.................hs....l.h.t....W.t..h...s....hh..t.h.............................................................................................	0	403	849	1049
+8502	PF08669	GCV_T_C		Glycine cleavage T-protein C-terminal barrel domain	Bashton M, Bateman A	anon	Pfam-B_933 (release 4.0)	Domain	This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase. 	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.25	0.72	-3.96	190	6206	2009-01-15 18:05:59	2006-03-08 14:03:29	6	31	3260	45	2055	5279	10043	94.50	25	19.51	CHANGED	ssFlGp-ul..tctpp.p......u........++hlul....................hp..t.shsptGttlht................ss.....ptlGtlTSusaussl.tpsluluhl...............sstsp..Gs...pl.plp.l.....................cu..pthsupl..sph	........................................................................sFlG+csl...tppcp..p...................G............s.....++lVGL.........................................thp...scs...s..s...cs..G...t..t..lht.............................................ss..........ptlGhlTS.G..sh.S..Pol......st..s..IAlAhl.t.............tth.sth..Gp....pl..l.p..l......................cs..cth.spls..............................................................	0	599	1224	1672
+8503	PF08670	MEKHLA		MEKHLA domain	Burglin T, Bateman A	anon	Burglin T	Domain	The MEKHLA domain shares similarity with the PAS domain and is found in the 3' end of plant HD-ZIP III homeobox genes, and bacterial proteins.	23.70	23.70	23.90	26.80	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.53	0.71	-4.67	26	387	2012-10-04 01:10:46	2006-03-08 17:08:34	6	5	225	0	141	393	60	143.80	34	29.20	CHANGED	PEshsLsphlspSYp.....pahGtsLlps.ps..uscshhctLac.pspulLspuhc..ssPlFsaANpuuLchhEs.ohssLpcls.chhh-.cssRcshssthsclhpQGasph.uGlplSshGRphphEpAssWplLss-p....sscs.AhhFsNWpFl	................................................shshsphlspSY+.........thhGt.pLlpsttt........sspphhchLac.t.s.Allspuhc.........spP.lFsaANpuuLchhEh...ohstLpsls.chsh..-...p...ss...R.cphp.s.h.splhpQ...Gas....ph..uGlplSshGRphph-pAlsWpl.ls....c-s......sh+s.AhhFhsWph.......................................................	0	29	90	116
+8504	PF08671	SinI		Anti-repressor SinI	Mistry J	anon	pdb_1b0n	Domain	SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex.  When complexed with SinI, the SinR tetramer is disrupted such that is no longer able to bind DNA.	19.80	19.80	19.80	20.80	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.94	0.72	-7.11	0.72	-4.51	17	297	2009-01-15 18:05:59	2006-04-20 09:18:08	5	4	127	4	39	164	15	29.60	46	35.33	CHANGED	LDpEWhpLlpEAhctGlohE-h+cFLphpK	..LDpEWhpLlp-AhsuGlohcphRcFLch.K........	1	7	20	25
+8505	PF08672	APC2		Anaphase promoting complex (APC) subunit 2	Mistry J	anon	pdb_1ldd	Domain	The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases.  Ubiquitin ligases catalyse the transfer of ubiquitin from the ubiquitin conjugating enzyme (E2), to the substrate protein.	20.30	20.30	20.30	20.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.89	0.72	-3.71	18	240	2009-01-15 18:05:59	2006-04-20 09:25:36	6	4	216	4	176	238	3	59.20	40	7.61	CHANGED	YIhuMLTNhso.LsL-RIHsMLKhh...ss.sshshopcELccFLsphVcEp+Lphs.GGsY+L	...............aIhGMLT.Nhsu..hsL-RIapMLKhh...ss.sshsho.pELppFLsphVp-tcLphs.uGsY+l........	0	56	90	143
+8506	PF08673	RsbU_N		Phosphoserine phosphatase RsbU, N-terminal domain	Mistry J	anon	pdb_1w53	Domain	RsbU is a phosphoserine phosphatase which acts as a positive regulator of the general stress-response factor of gram positive organisms, sigma-B.  The phosphatase activity of RsbU is stimulated by association with the RsbT kinase.  Deletions in the N terminal domain are deleterious to the activity of RsbU [1].	23.10	23.10	23.10	23.50	21.70	23.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.37	0.72	-3.97	14	334	2009-01-15 18:05:59	2006-04-20 09:26:18	5	8	325	8	32	137	0	77.00	54	22.08	CHANGED	cppY+plLccYLtspsEpsLY.pspcho+csIc+pIsPE-IVslH+shlppl..sl.....pcplhcohDlLlEVMhGYGhAY	..cp+YKuLlcESLssQD....KspLIKKCEKaTcEVI+KDVLPEDIV-IHKsYIhoLsLo.......cEDVh+TL.DVLQEIVKGFGYSY......................	0	10	19	29
+8507	PF08674	AChE_tetra		Acetylcholinesterase tetramerisation domain	Mistry J	anon	pdb_1vzj	Domain	The acetylcholinesterase tetramerisation domain is found at the C terminus and forms a left handed superhelix.	25.00	25.00	28.10	28.10	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.04	0.72	-4.43	6	95	2009-01-15 18:05:59	2006-04-20 09:29:11	5	3	45	8	45	93	0	37.40	68	6.56	CHANGED	DEAERpWKhEFHRWSuYMh+WKsQF.DHYS+p-pCusL	.DEAERpWKAtFHRWS.sYMhcWKNQF.Dah..SKpEpCssL.......	0	5	6	17
+8508	PF08675	RNA_bind		RNA binding domain	Mistry J	anon	pdb_1whv	Domain	This domain corresponds to the RNA binding domain of Poly(A)-specific ribonuclease (PARN).	27.90	27.90	27.90	29.20	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.13	0.72	-4.00	2	85	2012-10-02 20:46:34	2006-04-20 09:35:57	6	4	61	5	49	96	0	81.40	61	14.59	CHANGED	G.-.p.pR-HlhasTFPcpW+TuDl.phFpsFGslplSWlDsTSAFVuLpp.ptsp.slph.tYtpua+l.saApa.......pQhK	........GPDLQPKRDHVLHVT.FPKEWKTSDLYQLFSAFGNIQlSWIDDTSAFVSLSQsEQVp...IAlNTS..+.Y..AESYRIQTYAEYhtpKp............................	0	12	16	32
+8509	PF08676	MutL_C		MutL C terminal dimerisation domain	Mistry J	anon	pdb_1x9z	Domain	MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1].  MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation [3].	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.72	0.71	-4.59	108	4304	2009-01-15 18:05:59	2006-04-20 10:11:38	6	18	3912	12	1164	3441	773	144.10	26	22.12	CHANGED	s......h.hlu.....QlpssYllups...pcG.LhllDQHAA+.....ERlhYEpl.cpp..htp............psQ.LLlPhsl.pls.tp-hthlpcpt-tLpclGhplct....hGspslhlRslPshLtptph...ppllp-llspltphs.......p..........tthhcclhsthAC+sul+us...cpL	......................................hluQlpssY..l...l....s......p..s...............ps.....s......lhll..DQH..AAc.....ERltaEph..ppp.............hsth....................psQt..L....L....l.....P.......h....hl...cl........s..t....p-t..thlpc....p......t...s....t....L.p.c.....lG....lplp...........................husp....p....hhl+......u.l....Ph...hh...t.p...t....p..h...............p..p...l.......lh.-.lls...lhpps.....................p...........htphhpp.lht.h.huC+t.ul+ssp.........................................................................................................	1	401	726	969
+8510	PF08677	GP11		GP11 baseplate wedge protein	Mistry J	anon	pdb_1el6	Family	GP11 is a viral structural protein that connects short tail fibres to the baseplate.  The tail region is responsible for attachment to the host bacteria during infection.	20.80	20.80	21.00	79.60	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.39	0.70	-5.18	8	37	2009-09-10 20:27:43	2006-04-20 10:37:38	5	1	36	3	0	32	0	216.80	35	94.22	CHANGED	hohscsKAuVhSRcADFLta..c.suscD.sl.......hsspslGusTlsQltKGsY.PNVQSAIsDltshu.phsVGsVllsTsusuPpulpQ.s-hloFoGoVssss..sus.llIcVaGlPVpsssGsousplsspVpsshp-hlssphhhspspcc.sosuspLpl+YlDsppH.slssaoppGI..............TloppIsupu+sGYGTWshLGspTpTLssts.sss..lYYF+RIA	.....hohspstAtlhSRhAsalpac.spssshsV.......hsspsIGusolsQhtKGhhhPNVQSAIsDltshu.phPlsulllsssssuPpulpQ.sDhhoFoGoVssss..sGsslllpVaGhPVpsssGsousplsspVpstLp-hhspshhhsssppc.ssssspLplpYlDsppH.hhpsaophGI..............TlsppIss.u+sGYGsWphLGspohTLsstsssss..lYYFcRl.......................	0	0	0	0
+8511	PF08678	Rsbr_N		Rsbr N terminal	Mistry J	anon	pdb_2bnl	Domain	Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B).\	\	    The structure of the N terminal domain belongs to the globin fold superfamily [1].	27.00	27.00	33.30	82.60	26.20	25.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.55	0.71	-4.26	9	83	2009-01-15 18:05:59	2006-04-20 11:15:30	5	2	83	6	13	59	0	130.20	46	47.84	CHANGED	Fltcpps-LlppWsspl+clsspphshplo-chaEshspEal-lll.s.sptsspphpcclp-Fup+hVQlGhsLphlosGLptFt+hlaptMtccs..hscppt..h-llhcl-calsPlssEIlNpYohSWE	..FIpsN+s-LLssWhscMccpS-QhhsslspEthYEpTSKEFVDLIl.SslTcssscasE+L--FAEKlVpLGWPl+FlTTGLpsFGhLVYTs.MpD--....LcccE+..sDhaac.h.-oWlSshhNclVstYusoWE....	0	5	10	11
+8512	PF08679	DsrD		Dissimilatory sulfite reductase D (DsrD)	Mistry J	anon	pdb_1ucr	Family	The structure of the DsrD protein has shown it to contain a winged-helix motif similar to those found in DNA binding proteins [1].  The structure suggests a possible role for DsrD in transcription of translation of genes which catalyse dissimilatory sulfite reduction.	24.20	24.20	24.50	49.10	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.02	0.72	-3.97	13	56	2009-01-15 18:05:59	2006-04-20 11:17:52	6	2	52	4	29	53	5	66.60	48	66.35	CHANGED	-hKptIl-a.....u+pusKoKaYF+Dhhch....hP-hKsRElKKllscLVsEtpLtaWSSGSTTMYGLKspG	....-hKptll-aLp...tcsssKoKFYFpDFtch....hPDtKsR-lKKllspLVsEtpLpYWSSGSTTMYGLKGsG..	0	15	28	29
+8513	PF08680	DUF1779		Protein of unknown function (DUF1779)	Mistry J	anon	pdb_2fpn	Family	This is a family of uncharacterised proteins.  The structure of the ywmB protein from Bacillus subtilis has shown it to adopt an alpha/beta fold.	25.00	25.00	25.30	25.00	23.30	24.60	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.48	0.71	-4.46	14	234	2009-01-15 18:05:59	2006-04-20 11:23:29	5	1	231	1	55	184	0	191.20	31	80.00	CHANGED	ssplpc.................Wshtu+pphshsp..ctapphspphct-htphpW..spsp-.cchtchpGshpc...thptplpll.sstpssptpoYllYEhputt...ps.s.thcph.cpshclaptcshIFoClpGphssphsts.LpppupplLcphsA+pVEsltEpsFlSlSAaoscapptIhssscc.hNlQlALRps.uhss+TplslGTPIlTsEY	...............................................................................plpp...Wshhs.+p.hshsp....ppFpphlpplct..ctph.cW......ppp.-.hctp..php...th.p.......hppclhl.....s......hopcsspppoallh-hpusc...........h..chlpph.clas...pKshlaoC.lpGhl..s..s+..lpss...L.pscsp.p.lL.+.clsA+slEplcE...cs.a.VSlSAYspcac-...s.lpospcK.lNlQlAlRps....ssKspIsVGTP.IITsEY.....	0	25	42	46
+8514	PF08681	DUF1778		Protein of unknown function (DUF1778)	Mistry J	anon	pdb_1y9b	Domain	This is a family of uncharacterised proteins.  The structure of one of the hypothetical proteins in this family has been solved and it forms a helix structure which may form interactions with DNA.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.18	0.72	-4.15	45	1442	2012-10-02 18:44:02	2006-04-20 11:29:57	6	3	878	2	236	790	75	77.30	30	79.07	CHANGED	RlshRlss-p+pLlc+AAslpG.polosFllsuAhctApcllpcpch...lpLotpshptFh.ssLsp...PspPNscLccsht......phpp	......................lslRlss-p+sllccAApltG.pslosFllpuAhp...tApcllt..cp..ch....hhLsppsapthh.phL-p.....P..s.s..s..s..ttLpphhp....p...............................................	0	60	137	192
+8515	PF08682	DUF1780		Protein of unknown function (DUF1780)	Mistry J	anon	pdb_1y0k	Family	This is a family of uncharacterised proteins.  The structure of a hypothetical protein from Pseudomonas aeruginosa has shown it to adopt an alpha/beta fold.	19.70	19.70	21.50	21.10	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.38	0.70	-4.86	2	56	2012-10-11 20:44:44	2006-04-20 11:31:19	5	1	55	1	13	39	4	202.10	81	99.11	CHANGED	s-uDaLRLLThQAEQANsFLSNARKW-RERWVCQRhLpuLNlPYRp--FsAsGppPPDVLF+tAuFEVFFVLDEGRRLN-EWR-ELpRRRpAhSLpQLlRREt+PpRIsAuEL.hRLAPTLRKKAHNYpERGhshGELDllAFssLKRtV.DhNo.FPPPTEYLRQGWRSLShVGPTFARVLFAHssAPEFLRuNLGRSILFDsGluL	.............DDSDYLRLLTlQAEQANAFLSNARKWERERWVCQRLLQGLNlsaRsEDFsPAupE..PPDVLFRDutFEVFFVLDEGRRLNDEWREELsRRRSAFSLuQLVRREA+P+RIsAuELLtRLAPTLRKKupNY+ERGIDLGcLDIIAFsSLKREVLDLNoHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPGAPDFLRsNLGRSlVFDVGISL............	0	1	3	8
+8516	PF08683	CAMSAP_CKK	DUF1781; CKK;	Microtubule-binding calmodulin-regulated spectrin-associated	Mistry J, Baines A	anon	pdb_1ugj	Domain	This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.	19.60	19.60	20.30	22.30	19.00	18.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.53	0.71	-4.42	14	287	2012-10-02 14:14:57	2006-04-20 11:33:32	6	6	107	1	153	255	3	125.80	57	10.32	CHANGED	ss.cl.ahcsusKSN+slIpNAlsassLuGpsNcsp+ptlLc..clscsp...upHFlILF+..DspppaRulYoh.psps-phhKltGhG..PptlsptMlcshaKYsSusKpFptI..sKphosslDAhol.......K+	........................TGPKL.aKEPSuKSNKhIIpNAluH.CCL.A.GKVNEspKp+ILE...EhEKS-...ANHFLILFR..DuG...CQFRuLYo.......Y..sP-T..E.........E...lsKLsGhG.......P+sI.oc...pMl-tlYKYsSDRKpFopI.PuKThSsSVDAhTI....+sHLWQsK+................	2	44	60	101
+8517	PF08684	ocr		DNA mimic ocr	Mistry J	anon	pdb_1s7z	Family	The structure of an ocr protein from bacteriophage T7 has shown that this protein mimics the size and shape of a bent DNA molecule [1]. ocr has also been shown to be an inhibitor of the complex type I DNA restriction enzymes [1].	25.00	25.00	83.30	83.00	22.20	21.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.24	0.72	-3.97	3	48	2009-09-11 05:26:13	2006-04-20 11:37:54	5	1	11	3	0	48	0	97.00	83	90.53	CHANGED	MSNMTYsNVasHAYEhLKEpIRYDDIR-sDDLSDAIHEAADNAVPHYYADIFSVMASDGIDLEFEDSGLMPDTKDVT+ILQARIYEQLTIDLasDAEDLLN	.MSNMTYNNVFDHAYEMLKENIRYDDIpDT..DDLHDAIHMAADNAVPHYYADIFSVMASEGIDhEFEDSGLMPDTKDVIRILQARIYEQLTIDLW..........	0	0	0	0
+8518	PF08685	GON		GON domain	Mistry J, Rawlings ND	anon	Rawlings ND	Domain	The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins.  It contains several conserved cysteine residues.	22.60	22.60	24.80	23.10	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.68	0.71	-4.47	11	187	2009-01-15 18:05:59	2006-04-20 11:48:09	6	56	84	0	124	173	0	176.80	43	12.88	CHANGED	lspoCpElQphpuhtpDGEYhLpV..cGchl+IYCHGMpocsPpEYloLspGsp-NauphYshRLtssppCP.sGpc+psssspss..hshGtTpFsKlRlDlsshpIhssDapFupop.Gps.PauoAGDCYSss.+CPQGcFSINLpGTGh+lpssspWpspGshsshch....c+spssp+VhG+CGGaCGtChPp.poGLhLpVh	...........................................h..poCpElpt..h.p....sh..pc.......DGEYhL.l....pG+.hl...+...laCtsMpoppPKEYlTL.sp.G.p-NaSElYG.h..RL..ps.Ph...pCPaNGsRppsC..pCpps..hsAGhThFpKlRl..Dl..ss..hp..IhssDhpFApT.......G.........ps.VPaAT..A....GDCYSss.....cCP...Q..GpFSINLhGTGhplspsspWhspGp...a.ss..pl.....p+o.ssp+lhG+CGGaCG+ChPp.tsGL.lpl.h...............................	0	48	54	93
+8519	PF08686	PLAC		PLAC (protease and lacunin) domain	Mistry J, Rawlings ND	anon	Rawlings ND	Domain	The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins.  It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin [1].	26.40	26.40	26.40	26.40	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.35	0.72	-3.68	29	739	2009-01-15 18:05:59	2006-04-20 11:50:11	6	140	83	0	426	640	0	34.10	37	3.34	CHANGED	pCpDpsp........CtlVhpspLCphpaYpptCCpSCpp	...........pCpDpsp...........aCtlVhptpLC.sptaapptCCcoCp....	0	50	86	209
+8520	PF08687	ASD2		Apx/Shroom domain ASD2	Mistry J, Hildebrand JD	anon	manual	Family	This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.67	0.70	-5.06	14	259	2009-01-15 18:05:59	2006-04-20 13:14:24	6	9	75	2	149	229	0	247.60	41	24.19	CHANGED	cELs.....pplsstDcShs....shLsP.....csshsLhcuLhshsp.hht.t.tttthh.phs....................s...sossssahssuss+AE.Lh.chpshp......pt.spsE.spslstKKhELlppls+KLpsL+ctpcsLhp-hpsNssLGp...............................-lEutVpphCKPNEh-KF+hFlGDL-KVVsLLLSLSGRLARVEsALsslspsss.-E+toLhEK....+clLpcQpEDAKELKEpl-RRE+sVhclLuphLstEpLtDYp.......................................HFV+MKuALllEQRcL-DKI+LuEEQLcsLp-SL	..........................................................................................Ls.....ppl...D..h.....sh..ss....csshslhpslhs.s..hh....t...ttth..p..........................................................hsssssaassSssKA.E......Lh.ch.p-h...............tt.stp-.......st..-l.stK...K.......ELlp.uls+KLpsLc-tpcsLhp-hpsNssLGp...............................-VEAhlppl..C+PsEh-Ka+hFlGDL-KVVsLLLSLSGRLARVENAL.....ssl.s....ps.....u.....s...p.E..+ps.LhcK.................pclLhpQhEDA+ELKEslDRRE+hVhslLupaLstEpLtDYp.......................................HFV+MKuuLllEQRcL--KI+LG-EQLcsLh-SL.......................	0	20	30	74
+8521	PF08688	ASD1		Apx/Shroom domain ASD1	Mistry J, Hildebrand JD	anon	manual	Family	This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.  ASD1 has been implicated directly in F-actin binding.	25.00	25.00	36.10	26.00	23.30	22.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.19	0.71	-4.50	8	137	2009-01-15 18:05:59	2006-04-20 13:15:24	5	8	37	0	75	108	0	156.60	34	12.14	CHANGED	A+LQKS+STssLss.-uEsEssssph+st.....u.sos-uSFssTYK-+LKEAQuRVL+ATSF+RRDL-P.hPtp.h.t..cp.shphs.p.s.su.sspsshs.p...tt..ptso.....................sssusPpVsRIGGRKRhTsEQKh+SYSEPEKlNEVG............lpcEhs.t......spp.pposGohADRhKaFEcsuK	...............................pL.+SpSshtL.s...tsptp.....t.................s..s..-s.s.h.s.psY+spLK-AQuRV...LcATSF+.R..+DLc......Ps...t....hst...tp...shth...hp.s.s..........s.sps...........................t.st.......................tsts...ssRhGuR+RhTsEQKh+SYSEPEKhscVG............lst.t.p......................s.sohAcRh+hFEppsp............................	0	3	11	26
+8522	PF08689	Med5		Mediator complex subunit Med5	Mistry J, Wood V	anon	manual	Family	The mediator complex is required for the expression of nearly all RNA pol II dependent genes in Saccharomyces cerevisiae.  Deletion of the MED5 gene leads to increased transcription of nuclear genes encoding components of the oxidative phosphorylation machinery, and decreased transcription of mitochondrial genes encoding components of the same machinery [1]. There is no orthologue from pombe, and this subunit appears to be fungal specific [2].	19.20	19.20	23.30	23.10	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	989	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.92	0.70	-13.80	0.70	-6.87	19	144	2009-01-15 18:05:59	2006-04-20 13:29:25	5	4	120	0	112	159	3	740.80	21	85.92	CHANGED	M..........tustphpshlppCht++lsuspFhsLh...h.c+hPhsttshhphh...hpsp.tp.......................................t.ph-sl.ls.YlstLhh..hl.ssslLpshL...........................sphtp.sppphhh...phohht-.+lhpclhhshhpsphscsltpulthhs......slsphlptllsht.shp.s..st.tshhsp.-tsshh.s..hshllsslhtpphuhplLop...pts...h.tp...uhlshsspsuls...t..p+htthpp.p..hshhsps.spshssshhcshhsphhph...psplhshsshpocutLahYlssh..lsupsh.s...h..............hhp-LIpAuFcshusuh.......hps-sshshaha+sFlls+LPhhlhtht.........ssshsp...sh-.slp+Aluphpsst.sohophhsh...ssoshsDlRp-FlhuhthptLlP.osI.......pplhscs..s.psLslss.hshc-llpphpss.c+.........................hpQllspl-shpust.ssIssAIsElhpchsppp-h.pLpplsstLspps.puLsllLhFps..PpplLp.sL..sphL..........ss.t.hDE..DptE.QsVYppFGslLLLllshpa+Y.....clshhDl........uIsus.pS......FlhcLhttuspSpp.splsppppppLssWlpuLF.sp..GlSD-lMsu..ssPp-hYhLlPhlFpQslhAspsGtl.-hpsLpuGhEYhlpPFLlsuLlhhlhWLtpa.hhcppss.shslphhptllp.....sushSspu..ptlHpsVLpIsupsL.ppL+sh+stpsspp........t..cPhlcsl.spLsh.hs................sshpppcLp.hphh.................sh..psls.hho....s...phssssYsac.llssIchlusp+lLtsllcEL.......+hpsp......sususlslDlusshlsus.s...-shsh..t.hps....s....s....s..............p..hsh+sslph-c-.s.hhs-sDshtu...................u....p......................htshhpphp.t..sshsshstt.....hchctt.s..tsutpsss.............pchsslpp	...............................................................................................................h.thh.psh.pphss..F.th....h.tp.s.......p.h.....ht.p..t.............................................h.h..Yl..l............phl.shh.....................................................................................tp.............s.....hh..phhh...ptph.p.....h..h..........................h.thh..hhth........t..............t...t.p.h....h.t...............hh..h.th..pth.....th.t.......................t......t...hh..t..t........................h.p...................t.t.hp.h.....phh...t....p..l..ph.......h..s.....shl.ha.s...h..h.tps..t..................................h.-LI.ssFsshuphh........ppp.s...h.hhh.Flhp+lP.hh.th...................sh-.pl.pAlt.....ph...sp...h..........sshsp......................s......ss....slRp-FhhuhhhhtL...s.l..............phl.sp...s.pt.s.tt...hpphltph.t..pp.............................h.plltp.h-ph.tsst..ttlstslhphhtphhpphph.pltplst.L..p..p...slshhLha.p..s.tllpsLhthl............................s..s.t.........h-p..sp................h-.pshappFG.llLhllshh.pa..........sls..cl.................hhts..ps........l.hchhttsp....spt.ppltppp.pp.lssWlpuLF........tp........GloD-hhpu..ssspphhhLlshlapQslhAhp...tGhl.p.p.sLpsGhEY................hhpshLhs..sll.sl.......haLtp......hh....pp.p...p.p..lphh..hlh........ss.o.pt.......pthhpsVLplsu..L.p.L+t.hphp..tp..................t...s.hpsl...h...hp...................s..p..tplt.ht...........................................hh..p..sl..h......p......s...Yshc.hhthlph.ss.phl..llcpl............th.sp............stpsphshshhh..hlsh..h....th.........ht.........................................................................t...p.c..h..ptc...hh.ct.p..ht.................................................................................................................................................t..........................................................................................................................	0	28	61	96
+8523	PF08690	GET2		GET complex subunit GET2	Mistry J, Wood V	anon	manual	Family	This family corresponds to the GET complex subunit GET2.  The GET complex is involved in the retrieval of ER resident proteins from the Golgi [1].	20.10	20.10	20.20	20.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.90	0.70	-5.17	9	97	2009-09-11 07:52:02	2006-04-20 13:35:14	5	2	96	4	72	96	0	248.30	21	81.04	CHANGED	pLS-sEKR+LLRERRQtKhSpGsASuRLNcIhuQupusphso....pSVLDpcsssssssspssps............................ssPElpDl.pshsss.............pspsstpslD...chFpplhphQstG....tssss-sshsslhsMhpphts.................s.stostusppst..hhpppLlcYppYphphhKhhhlll+ashhLhsalYahhp.ss.h..h....hhhptL.p.h.sspsFFolFsThEllhluhYYplhpplphhssssshp.ssKllshsSMV....LP.ltshcshVlhhLpYa-lluMhlsDlshVlVhhGLhoh	.............tEpt..RLhRERRpAKh.ppGsASuRLsKITu..u....tssptss.......pSsh-ss.s.sss.s........ss.s.s...sspp................................ssPc.p-..p..t.h..s...........................................t..tptsspshss.p...chhptlht......p...t.t.......................t.........s.ss............t..s...sshs....p....h.....h.p.hh.sh...ss.s..........................s..........................................p.........hh..h.....h....h.h....h...hh...hh.........................................................h.hh.s.Eh............................................................................................................................................................................................................................................................................	1	10	35	62
+8524	PF08691	Nse5		DNA repair proteins Nse5 and Nse6	Mistry J, Wood V	anon	manual	Family	Nse5 and Nse6 are non essential nuclear proteins that are critical for chromosome segregation in fission yeast [1].  Nse5 forms a dimer with Nse6 and facilitates DNA repair as part of the Smc5-Smc6 holocomplex.	25.00	25.00	44.10	30.90	19.20	21.00	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.73	0.70	-5.98	16	54	2009-01-15 18:05:59	2006-04-20 13:39:35	5	2	28	0	31	46	0	438.90	23	94.46	CHANGED	Msusspsp...s.sp.s............hhVp.spcc..s.Ethsuhp.htshspllh.h-t...........t...h......t-llhhhhohssh.ssa.csshlcc.t.hs.st......t.hsppsht.lpphhptLpphcspphsp.slphh+sphhhh.cp.......phchphspphcsptspphhchhhpsst.sp.psh.hlshcsshpshhsh.t.t.thhtsh.hshhhpp.st.hp.h..sLsshl..h..tppssshhhph..tp....hhchlhslhsl....+phhhh.scsstt.pp............lhtFlphltshphhpshspph..hhsshpph.t..hthphhslYhph.-hshs.hahphs+hhsphKtt...............lLppl.pshph....h..sphlhp.hcslhsppchpphhtFh.....................................hlhshssp.hsh..hp.plhphlcs............................phlDhstpss.pch.lsl.p..hh.........................................................................LKshhp	...................................................................................................Mss.........ts..st........p.....h.Vt.h.cc..s.Ehlps.hh.-s.sp.L...Ep.........t.pthhh.s.....sllhhhhh.p...pph.pps..ct.s.hshph.........p.hshts...h..pphhshlpchps.phphh-..hhppphhls.sol......pschppt.thp.tphsct.hslhh+pshSsc.cs.phhohps.Ycphhsh..pcpshh.t.hhhshphspssEFlphhh....oLos.L......p-pss.hh.s.......pch..shh-.Lhslasl....+.hhah.p-ssp.s.spph..........LtsFhp.l.sRphhsthpp.h..hhps..ph...s.p.........sphhssYhp..-ps.hhhah.hh+h.P.hcst...............LLt+l.sscphhp.p.h..pp.lhp.hppLhshpshpphhhFh...................................................lp.hust.hsF............ps.plhphhcs............................shh-.sspss.pcs...lsI...................................................h......................................	0	4	14	29
+8525	PF08692	Pet20		Mitochondrial protein Pet20	Mistry J, Wood V	anon	manual	Family	Pet20 is a mitochondrial protein which is thought to play a role in the correct assembly/maintenance of mitochondrial components [1].	21.40	21.40	21.60	22.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.95	0.71	-4.23	6	105	2009-01-15 18:05:59	2006-04-20 13:51:08	5	3	29	0	59	83	0	97.30	28	44.10	CHANGED	KKtspDappLPRVPoTpaLctc-hosDlLYSGYRPlhhss+-sPLhpppps+.hcathchp..........chsEPhpP....................................WsSSAhGhEaasEW-NVPs-llKcLKPFcssp.pc	......................lP+VsoTpal.tp-hppphLauGYRPlh......h....ss...pt...............tp.....ptpp.....hph........................t..................................................................................W.sS..G.h.a.s...ac.lP..hhtphKPFc......t................................	0	6	23	50
+8526	PF08693	SKG6		Transmembrane alpha-helix domain	Mistry J, Coggill P	anon	manual, Wood V	Domain	SKG6/Axl2 are membrane proteins that show polarised intracellular localisation [1]. SKG6_Tmem is the highly conserved transmembrane alpha-helical domain of SKG6 and Axl2 proteins [1], [2]. The full-length fungal protein has a negative regulatory function in cytokinesis [3].	42.00	42.00	43.00	42.20	41.90	41.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.96	0.72	-4.64	13	66	2009-09-11 17:06:57	2006-04-20 13:56:40	5	4	37	0	39	61	0	38.70	41	5.65	CHANGED	Ksoc..tspsssluluVslPVuVIllVLhhhLhhhaRRpK	.......os.tpssuVslAluVulPlGVIlllLhshLhhhaRRsK..	0	8	20	33
+8527	PF08694	UFC1	DUF1782; 	Ubiquitin-fold modifier-conjugating enzyme 1	Mistry J, Bateman A	anon	pdb_1ywz	Domain	Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1 is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family represents the E2-like enzyme.	25.00	25.00	74.30	44.60	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.07	0.71	-4.76	9	167	2012-10-02 15:28:41	2006-04-20 14:03:43	6	2	145	10	111	163	2	153.40	68	93.63	CHANGED	tsT+polspIPLLpTpAGPRDt.-tWlpRLKEEYtuLI+YVEpNKpsDNDWF+lE.SNcpGT+WhGKCWYlHNhhKYEFDlpF-IPlTYPsosPEIslPELDGKTsKMYRGGKICLTsHFtPLWu+NsPKFGIAHALALG.....................LuPWLAsEIPsLl-pGllK.p-c	...........p.sT+cslupIPLLpT+AGPRDt.-hWsQRLKEEYpuLIp...YVcsNKpuDNDWFRLE.SNcEGTRWaGKCWYlHsLlKYEFDlEFDIPlTYPsTAPEIAlPELDGKTAKMYRGGKICLTsHFKPLWARNVP+FGIAHAhALG.....................LuPWLAlEIP-Llp+GllpaK-................	0	49	65	89
+8528	PF08695	Coa1	DUF1783;	Cytochrome oxidase complex assembly protein 1	Mistry J, Wood V	anon	manual	Family	Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence [1]. The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex [2].	21.10	21.10	21.10	21.10	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.31	0.71	-4.59	43	323	2012-10-01 19:51:31	2006-04-20 14:04:22	5	3	276	0	200	455	12	113.00	22	61.06	CHANGED	hhhh.shaslshssuhhhlhNhpKppSsllsssLatlRpSspsp-hLG..-tIshpsth.....PWlpGplNpl...pGclc.lsFsV+Gs+...u.pGpl+lpusRcsctt.Fplccaslpsc....supp...lcLlc	..............................................hh..h..lhhhshs.s.hhhhh....hs.h...p.......h....pp....o.....s....h..h.ppslhtl+psspshphL....G..-.....s.hppth...............hls.G.phNps.........pG..c..hs..lphsVpG..s+..................u..pGplhhpup.Rps.p.p....aphpphtlphc....psp.l.l...........................................	0	61	111	165
+8529	PF08696	Dna2		DNA replication factor Dna2	Mistry J, Wood V	anon	Pfam-B_8878 (release 19.0)	Family	Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, ( 5'-flap endonuclease) and helicase activities.  It is required for Okazaki fragment processing and is involved in DNA repair pathways [1].	20.70	20.70	20.80	20.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.14	0.70	-5.02	31	301	2012-10-11 20:44:44	2006-04-20 14:14:05	6	24	251	0	216	318	21	196.90	29	17.42	CHANGED	llhhpcsssppptlhL+ssWhpss.hphGDhlHllu.........phssssshslsssps..hlIlpPDhLlSuTslusSlpC.R+uVLp-ph.ptssssohshlhGTIlHElFQcul.....pssphssphlp.phhppslc..pah.plahlshs.hspltpclpp.thsslppWsppahpppsssp.h..............tpsppttlslscllDIEEsIWSPpaGLKGpIDATlcsp	.................................h.....ppttppphshLpstWh...pss..hp.Gshlclhu......................................phs...sp.sp.hl.lsp...sp..s........hlIlp..PDhLlSuTslusShp...C.R+uVLp-ph...+s.............s......sp......ss.....t.shlhGollHEl...FQcul.........................sp....p..h.s...phlp...phhpphlp.......phlpplYt...l......shs..s-s.ppcltp.hhsslppWsppahpppsp.sp.h.................................tpspp.phplscllDlEEplWSPhaGLKGpIDsTlps................................................................................	0	73	117	180
+8531	PF08698	Fcf2	DUF1784; 	Fcf2 pre-rRNA processing	Mistry J, Wood V	anon	Pfam-B_13623 (release 19.0)	Family	This is a family of eukaryotic nucleolar proteins that are involved in pre-rRNA processing [1].	20.90	20.90	22.20	26.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.25	0.72	-3.98	24	326	2009-01-15 18:05:59	2006-04-20 14:20:19	6	6	281	0	231	325	5	97.50	39	31.77	CHANGED	KppccsssspWFsh.cs-..lTsEl++DLpll+hRsslsPc+aaK+sctcp...hPcaFphG.......Tllpsss-a.........au.oRh............s++cRppohl-E...Llp-sshpca.....h++K	...................pppcosGssWFshsts-..lTsElK+DLplL+hRs.slDPK.RaYKK..sctct.....hP+aFQlG.......Tll-uss-F....................as.uRl............s+KpRKp..Tll-E...Llu.Dpchppa..++K...................................................	0	82	129	195
+8532	PF08699	DUF1785		Domain of unknown function (DUF1785)	Mistry J, Wood V	anon	Pfam-B_1585 (release 19.0)	Domain	This region is found in argonaute [1] proteins and often co-occurs with Pfam:PF02179 and Pfam:PF02171.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.47	0.72	-4.60	46	958	2009-09-11 17:06:15	2006-04-20 14:26:01	5	11	239	8	597	914	1	53.60	41	6.15	CHANGED	hslupSF.Fstp...........hsp.......sLGs.Glpuh+GaapSlR.........so.....ptu.LhLNlDVSsssFhcs	...............................................sVGRSF..Foss.............................tst......tsL..Gu...G..hEsWh........GFaQSlR.........Pu.......pht..hhLNI.D........VSsTAFacs........................	0	155	301	462
+8533	PF08700	Vps51		Vps51/Vps67	Mistry J, Wood V	anon	manual	Family	This family includes a presumed domain found in a number of components of vesicular transport.  The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi .  Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1 [1].  Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues [2].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.70	0.72	-4.14	56	831	2012-10-03 17:31:52	2006-04-20 14:27:19	6	16	297	0	605	1053	2	83.80	20	11.90	CHANGED	hsssshcscphhp.t.htpps.....l....pplhphcpplp........pplpphpp-l+phVhpsYpchlpss-sIpphcsph........pplpsplsplppshpphspt	..............................thsspthh.........p..t.ht.p.ps.....................h....pclp.phc.pplp...................................pphcppsp-l+phVhc..........sYpchIp......su.......cpIp.p.hcsph............pplps.lsphppthtth...t...................................................	0	197	331	497
+8534	PF08701	GN3L_Grn1		GNL3L/Grn1 putative GTPase	Mistry J, Wood V	anon	Pfam-B_22650 (release 19.0)	Family	Grn1 (yeast) and GNL3L (human) are putative GTPases which are required for growth and play a role in processing of nucleolar pre-rRNA [1].  This family contains a potential nuclear localisation signal.	21.20	21.20	21.40	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.09	0.72	-4.08	36	317	2009-01-15 18:05:59	2006-04-20 14:33:43	6	5	270	0	228	328	2	78.00	37	14.88	CHANGED	+hRaKIcKKsut+pRKt+KtAK..Kssph+S.+p.p.K..DPGIPNsaPaK-clLpElEcc+pppcEc+ppp+tppptc+pttp.cps	...................+hRaKIpKKstt+pRK.RKt....A..K...Ks.sp..........h.....+p..+t..+.K.......DPGIPNtaPaK-clLcElE...pc+pptc..Eccppp+ptpppppptt...tt................	0	78	127	190
+8535	PF08702	Fib_alpha		Fibrinogen alpha/beta chain family	Mistry J	anon	pdb_1m1j & pdb_2a45	Domain	Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood.  This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).	29.50	29.50	29.50	33.20	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.15	0.71	-4.07	20	256	2009-01-15 18:05:59	2006-04-20 14:42:43	5	5	86	240	81	298	0	130.80	29	29.67	CHANGED	scpssstpsD-caGshCPTsCclpshLs+hcpslc.pclpplcshLpphpppsssscphlpplpshhpscpssspssptlhsthpcslccpl..hhhh-pplssp.ppIchLQsslpsppp+Ip+LEscIspthcpC+pPCpcos..pIss	..........pts.shh.DpcaGshCPTsCtltshLsphppslc.pclppLcs.Lpphpppospspphhptlpphhpsctts.psst..sl....st.....hpps.+chh...hhhcth..ph.pplphLpphlps...chppLc.cls...p.CptsCppss..pl..s............	0	3	9	33
+8536	PF08703	PLC-beta_C		PLC-beta C terminal	Mistry J	anon	pdb_1jad	Domain	This domain corresponds to the alpha helical C terminal domain of phospholipase C beta.	23.10	23.10	23.60	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.23	0.71	-4.58	8	215	2009-01-15 18:05:59	2006-04-20 14:48:55	5	16	68	2	101	201	0	168.00	38	15.68	CHANGED	hDp-....l.-h+-cppQcLLpLREEQacsp++pKcpHlppthpKLpElAcEpQssQLK+LKElsE+EKKELKKpLD+KRh-+Is..pA+Tp-KttpEc-KpEIN+SHIQEVVQsIKpLEEsQp+RQEKLpEpps-sLQpIp-cEPphQuphht-aptch+pLPsEVpchLppptpcs...........shPstscs	.......................................p+hh-L+-+QpQpLL.pLRpEQh.sEttp+ccH......lcphhpKLp-lAcEsQs..sQL.K+LK.EhsE.+Ep.KELpK...pl-cKRppc...Ip......pspo+DKpp.tE.c.KpEl.s+SaIpEsVph.I+.RLcEspp+RpE+L.cpppplhQQIt-c.cs.c....hpt.ph.....tEh.ptphttL....-l...h......................t......................	0	10	19	51
+8537	PF08704	GCD14		tRNA methyltransferase complex GCD14 subunit	Mistry J, Wood V	anon	Pfam-B_5615 (release 19.0)	Family	GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.52	0.70	-4.88	7	1145	2012-10-10 17:06:42	2006-04-21 14:09:47	5	11	975	20	564	2188	468	194.50	31	60.23	CHANGED	GalYlLtPTPELWTlsLPHRTQILYosDIuhIhhhLEl+PGoVVsESGTGSGSlSHuIhRolAPTGHLaThEFHppRAcpAR-EFccHtl...sp.hVTVpppDVC.ppGF...tlsthADAVFLDlPuPW-AlsHAhssl.+hcGGRhCSFSPCIEQVQRTCpsLtphGFsEIpTlEVL.psasVRpsplsh.DL.utst.cssp..................ssssss..pSus.................Ph.....................pEshGHTGYLTFAsh	....................................................................sh..shP+t.sQl.lY.sKDh.u.......I.l.h...h.h.-..l.h..P.G.s.p...........VlEAGsGSGuLohsLhRA.l..................u.....s............p........G.p..lho.aE....h...+p..-..ht....ch.A............p...p...s....h........c......p....h...t.h.................sp....h..pl...p...h...p....D.....l..t.....p.......p.......u.h.......................................................t...t...............s............h........D.....t........l..h.....L.....D....h....s..P..W..p...s...l..p...p.st........c.....s.............L...................hs...........G.......G.............h..l.ss.a.s.....s...sl......p.Q..l.......p.......+s.......hc..sL..+..p...t...s...a...s...........-.......p.shEs...hh.Rpac.s.....p.....................................................................................................................................................................................................................................................................................................................................hh...............................................................................................	0	193	343	476
+8538	PF08705	Gag_p6		Gag protein p6	Mistry J	anon	pdb_2c55	Domain	HIV protein p6 contains two late-budding domains (L domains) which are short sequence motifs essential for viral particle release.  p6 interacts with the endosomal sorting complex and represents a docking site for several cellular and binding factors [1].  The PTAP motif interacts with the cellular budding factor TSG101 [1].  This domain is also found in some chimpanzee immunodeficiency virus (SIV-cpz) proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-8.16	0.72	-3.92	130	21799	2009-01-15 18:05:59	2006-04-24 12:03:20	6	32	62	6	0	17390	0	35.10	70	10.25	CHANGED	.QSRs.......E.....PT...APP.A............Esat.hGEE....h.sss...K.....QEt+....D.........+.........PL	.............LQS.RP..........E.......PT......A..P.P..A........E.S..F.R..FGEE........h..TPu........K............QE...h........D..............+.E........PL.................	0	0	0	0
+8539	PF08706	D5_N		D5 N terminal like	Mistry J	anon	manual	Domain	This domain is found in D5 proteins of DNA viruses and bacteriophage P4 DNA primases phages.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.96	0.71	-4.12	74	1334	2009-09-10 21:39:52	2006-04-24 16:40:24	6	39	1034	0	232	1230	422	157.50	16	23.13	CHANGED	Aphhtcha.....tpp..ltasstht...............Whh.asuh.........Wp.s............ppthtphhppht.....chhhtpt..............................................................th.phhhpttpspthpshlpphpt......................................hssphpchDsc..shhlshsNGll..Dlcs..Gph....................ts..tcs.cchhTp.....hhshsa....................ps.......................ssst.........appaLpc...hhs	..............................................................................................................................................................................................................................................................................t...............h...a.s..................Wt..................h.t..hh.tphh.......t..h.tth....................................................................................t.h.....t.h..s...pptlp.s..slcthp...........................................h.ht.pph...c.ss......pLlshp.N.G.ll......Dlco......uph...........................................................ps.....ass..cp..hhop....hssssa.............................................ss........................................s.....pssp...........apcaLpph...............................................................	0	80	154	199
+8540	PF08707	PriCT_2		Primase C terminal 2 (PriCT-2)   	Mistry J	anon	Aravind	Domain	This alpha helical domain is found at the C terminal of primases.	20.90	20.90	21.00	20.90	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.87	0.72	-4.11	50	419	2009-01-15 18:05:59	2006-04-24 16:58:30	6	30	316	0	84	430	307	76.60	23	10.50	CHANGED	clcshLphlss...s.h.DYcsWlplGhAL+pth.....u........spuhclWcpWSpp........us+Ycs.pc..spppWpoF.....csss...lThuTlhhhA	...................htthlphlss....s.h.sYppWlplG..hAlpsth......u.........cpuhphapcaSpp........us..+Ypt...pc.....scphW..psh........psss........lshuTlaahA...........	0	26	56	72
+8541	PF08708	PriCT_1		Primase C terminal 1 (PriCT-1)	Mistry J	anon	Aravind	Domain	This alpha helical domain is found at the C terminal of primases.	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.29	0.72	-4.16	93	1023	2009-01-15 18:05:59	2006-04-24 17:24:04	6	23	745	0	118	843	165	69.20	23	18.39	CHANGED	pttht..stssthGRNssLFchs.tthh.hctlsppt..................lhphspthNsp.h......ssPLstpElcpss+Slh+hphp	.................h....httsptuRNssLhphs...tthh.hptlspph.................shphhth.hNsh.h.......ssPLs.tpElpph.hcShh+hph..........	0	47	77	105
+8542	PF08709	Ins145_P3_rec		Inositol 1,4,5-trisphosphate/ryanodine receptor	Mistry J	anon	pdb_1xzz	Domain	This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor.  Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity [1].	20.30	20.30	20.30	20.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.15	0.70	-11.37	0.70	-5.31	19	714	2012-10-02 19:42:32	2006-04-25 13:25:41	6	68	123	27	374	627	9	196.90	40	6.46	CHANGED	ppsSFL+hGDlVSLYsEuosp.........GalSThGLs--+CllpssusshssP...Ph.cFcsClFpl.sPhsphsApcphhput.scpssss..-........tuAphpp+ps........t..lhYGpslQ.LLHh+SshYLos.pphPuhh-KsAh+VsLspsus.Eu..sWahIpPhaKhRStGDsVsVGDcVlLssVsus.......p..LH.uss.thh-ssst.hpVsussppTsWplphahpts-s	.......................................................................................p...t.Lp.h.sD.lsL.s.u.shp................hhlu.s.....G.h.s............s..ch..C..h.lpsts.....ss.psP.......................P...chp....ChFhl.p.h...p....hpA........p.......ph...hp...s..t..s...c...tss..pt..t......................................................puAphtt+ps.............................................................lhY.G.p.s.I...Lh.HhpSsh......YLos.pp........uhh-...K.A..hc....VsL.......ppsus......................Eu....sWahIp.P..h......K...R.....S.p.G.....-..p...........V....hl.GDcllL.ss.V...su.t.................p..LH.u.................hss...s...s...........h.......pV......s......u..s..p.p......T.Wpls.hhphp....................................................................	0	133	156	257
+8543	PF08710	nsp9		nsp9 replicase	Mistry J	anon	pdb_1uw7	Domain	nsp9 is a single-stranded RNA-binding viral protein likely to be involved in RNA synthesis [2].  Its structure comprises of a single beta barrel [1].	22.10	22.10	22.70	41.20	19.90	22.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.35	0.72	-3.91	9	698	2009-01-15 18:05:59	2006-04-25 14:22:47	5	34	208	10	0	632	0	103.80	56	2.26	CHANGED	NNElhPspLKppsspAusD.ssssss.upAhYNstsGppalhAhlSspssLKasKaEpcsG..hlslEL-PPC+Fhl-sPpGPplKYLYFVKsLNsLpRGtVLGhIuATVRLQ	.............NNElhPstL+ppustAuss.ssssss.upsaYsspsGtphlhAllSspssLKas+a.pssG..hIhlEL-PPC+FsscsspG.P.cVKYLYFlKsLNoLpRGhVLGtIuATVRLQ	0	0	0	0
+8544	PF08711	Med26	TFIIS;	TFIIS helical bundle-like domain	Mistry J, Moxon SJ, Bateman A	anon	pdb_1wjt & Pfam-B_7936 (release 8.0)	Domain	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex [4]. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5 [5,6].	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.24	0.72	-4.46	76	1525	2009-01-15 18:05:59	2006-04-25 14:52:23	6	42	326	13	982	1411	10	52.80	30	10.64	CHANGED	clLptLpp..hs.ho......t-hLppTclGhsVstl+Kp............ssppltplAcpLlpc..W+chlp	........................lLptLpp....hs.lo................h-hL.p....p.T.p.lG+sVs.tl+Kp....................pspcl....pphA+pLlpp..W+chl...............	0	274	473	734
+8545	PF08712	Nfu_N		Scaffold protein Nfu/NifU N terminal	Mistry J	anon	pdb_2ffm	Domain	This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein.  Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters [1][2].	21.30	21.30	21.40	21.80	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.37	107	1440	2009-01-15 18:05:59	2006-04-25 16:01:34	6	14	1107	3	493	1036	1572	85.90	34	36.69	CHANGED	Ip.TEsTPNPssLKFlP.uppllssu..o..h.-FssscpAts....SPLAppLF.plsGVpuVFhGsDFlTVoKsst.s-WsplKPplhuhI.h-ahpuG	.............IphEsTPNPsohKhl.....u..ps...lhspt....o....h-a.h.st....p.pstp.......usL.sppLh..pl.-..GVpuVFashD....FloVsK.......psc...s...-WpplhPplhusl.h-.h........................	0	159	305	413
+8546	PF08713	DNA_alkylation		DNA alkylation repair enzyme	Mistry J	anon	pdb_2b6c	Family	Proteins in this family are predicted to be DNA alkylation repair enzymes.  The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.32	0.70	-4.83	89	2486	2012-10-11 20:01:01	2006-04-25 16:53:16	6	10	1475	10	471	1879	159	170.60	17	82.37	CHANGED	lpppLpshus......sppAtthppahK.......pphtalGlpsPth+pls+phhpphsht.........thsppLapssh.+Et+hhAhpllhphh..pc....hs.s................hphhpphlt..phstW-hlDthssplluphlhp..............thtshlhpWspo-shWhRRsAlltplhatcp........schptlhphspthls-p....-.hIpKAlGWhLR-huKp.c.shltpFlpp........ctpt.hsthuhRpAhchl	.....................................................................................................................................p.........t..h....................hhGl.hs.hp.hhcthh.t.................................h.t..hh......t..p....................-.............hh.uh.hh..........t........t.t.............................h..htthh.....ph.s..at.hhD.h....h..hhtth.h.t........................h..phh.pW.h.ts.p.....p...aht.Rh...u...h....h..........h.....h.h.p............tp..t....h..hthltt..h..p.sp..................p....hl.pp.ulu.hLpphutp.p.phhh....phlp..............................................................................................................	0	196	347	408
+8547	PF08714	Fae		Formaldehyde-activating enzyme (Fae)	Mistry J	anon	pdb_1y5y	Family	Formaldehyde-activating enzyme is an enzyme required for energy metabolism and formaldehyde detoxification.  It catalyses the condensation of formaldehyde and tetrahydromethanopterin to methylene tetrahydromethanopterin [1].	20.90	20.90	21.30	23.50	18.40	20.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.62	0.71	-4.54	45	346	2012-10-03 01:04:38	2006-04-25 17:32:49	6	2	176	10	133	327	105	146.40	45	77.97	CHANGED	lGEALlG-Gs.........ElAHIDLlIGs+sGPsGpAFANuLsststGHTsLLAVlpPNLhsKPsTlhlsKVTIKstcQAsphFGPAQuAVA+AVADuVp-GlIPc-ps-DlsllsuV.......FIHPpA........pDcp+IacaNYpATKhAIpRAhpshPshcclltp+cpupHPhhu	..........hGEuhlstus.........phAHIDLlIGs+s..usstpAFANuLsspppGaTsLLAVlsPNLhsKPsTlhhsKVTIKss.cQAsphFGPAQtAVAcAVsDuVt-GlIPt..-cA-DlhIlluV.......FIc.ps.........D.pcl.chNYpAsp.AltpAhtt.PphpplhtttpphtH.h.s.......	1	34	93	115
+8548	PF08715	Viral_protease		Papain like viral protease	Mistry J	anon	pdb_2fe8	Family	This family of viral proteases are similar to the papain protease and are required for proteolytic processing of the replicase polyprotein.  The structure of this protein has shown it adopts a fold similar that of de-ubiquitinating enzymes [1].	21.40	21.40	21.40	23.00	19.60	20.50	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.10	0.70	-5.36	5	760	2012-10-10 12:56:15	2006-04-26 12:01:56	5	34	211	22	0	801	0	290.70	29	6.89	CHANGED	csKslTIalTEDGVNl+oVVVcsucSLGpQFGsVas+sKshptVhPuDssEDKplhhlPosDhlt..uFKsslpYaoLDsptYuhYhssL..spKWph..VsGFplLcWsDNNCWVNSslllLQtuKl+Fpu.uLssAWsKhluGDsssFVAalYAsssusVG-hGDAc-sLo+LuEHhssDusssLL+hsVCspCGhK.osolsGlEAsIh.suolshDshKTGYS.sCsCGpcssscVlpssusalllsAs-s.PuAss+LpsGluhss..FoGSsssGH.YT.apAAscAhY..DGA+hpKaucpossVTAlah+tuhhopslhPVus	.....................................................................................................................ph.lhhT.Dssp......hcs..Vt.s.ohG.ph.G.s.shhcstshpt.hhstst......psc.hh..h..s.....D...........................sh.....c........hh....s....hD..t.p.hh.Yhp..sL...hppaphs.h..s..shhslK.sDNNCalsushlhLQth.c.lpFps.hlp-AWtcapuGcsssFVuhhhA..hsshp.hG-.GDuc.hLppLhphhs.h-.sstlhp.pssspCG.K.ppphpGl-ushh.hts.shpphcpGhp.sCsCGpssspplsphcushlhh..p..s........s.....ss.tp.h..pu..s..shss..a.p..G.shp.sGH.YT..a.st..p..p..s..h..h...Dus....+hpKhsc.ph.lT.s.hhh.h..s.h.........t..................................................................	0	0	0	0
+8549	PF08716	nsp7		nsp7 replicase	Mistry J	anon	pdb_1ysy	Domain	nsp7 (non structural protein 7) has been implicated in viral RNA replication and is predominantly alpha helical in structure [1]. It forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure [2].  The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase [2].	25.00	25.00	25.70	25.20	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.70	0.72	-3.59	7	563	2009-09-11 00:21:17	2006-04-27 12:56:27	5	32	199	10	0	567	0	84.10	55	1.51	CHANGED	SKLTDlKCTsVVLLulLppL+VEuNSKhWAaCVpLHN-ILhssDsscAh-pLluLLusLhShpuslD......LscLs-shh-ssolLQ	..SKLoDVKCTsVVLLslLppL+VESNSKhWuYCVpLHN-ILhscDsscAhEKLluLLssLhSh..puslD...........lscLC--hlcssolLQ.	0	0	0	0
+8550	PF08717	nsp8		nsp8 replicase	Mistry J	anon	pdb_2ahm	Domain	Viral nsp8 (non structural protein 8) forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure [1].  The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase [1].	25.00	25.00	29.20	28.20	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.44	0.71	-4.71	9	574	2009-01-15 18:05:59	2006-04-27 13:42:27	5	35	209	6	0	578	0	198.40	54	3.56	CHANGED	uVASpFsslPSYltYEsA+psYEcAlu...NGuus.QllKpL+KAhNlAKStFDR-tuVQ+KL-RMAEQAhTsMYKEARusDRKSKVVSAMpohLFuMLR+LD.sulssIlspARsGVVPLulIPtsuAsKLhlVlPDhssas+hhstssVpYAGslWsIppVpDsDGcsV+lp-lTpp.....Nt.sLsWPLllsspR.....s.VKLQ	....ulsSEFuslPSYstYEpA+psYEcAlu...NGsus.Q.LKpL+KAhNIAKStFDRDtAVQ+KL-+MA-pAhTpMYKEARusD++uKVlSAhpohLFoMLRKLDssuLNsIlspA+sGsVPLshIPhssAsKLhlVlPDhpoaspss-sssVTYAuslWpIppVhDADGp.lpLsEIshs.....ss.NlsWPLllsspR..tsps.stLQ...................	0	0	0	0
+8551	PF08718	GLTP		Glycolipid transfer protein (GLTP)	Mistry J	anon	pdb_1wbe	Domain	GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids [1][2].	25.60	25.60	26.00	25.60	24.90	25.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.63	0.71	-4.17	68	702	2009-01-15 18:05:59	2006-04-27 13:59:54	6	10	261	19	468	642	6	140.30	27	56.28	CHANGED	spl.sptFLcuscplsplhc.........hl...G.ssFuhlppDltuslp.+lcphh..tsspt...............................hpoLpshlptEhpsth.t.tps.................ouocsLLWLp.........R........u.LcFlthhLcplhs........s.spp.....hsssspcAYspoLptaHuall+pshp.........lAhtusP........sRcphhptlssss	............................................................t..l.sp.FLpusptls..hhc.............hl...G...ssFs.lppDlhusl..p.+lcphh....ss.s.tp...............................hpoLpsllptE.hps..thhp..hps..................ouocuLLWLp..........R...................u.LcFlthhLpplhs.......s.ppp..............lpssh.ppAYspo.LptaHuWll+tshp.....................hAh.hshP........pRppFhttls...t........................	0	153	245	359
+8552	PF08719	DUF1768		Domain of unknown function (DUF1768)	Mistry J	anon	pdb_2b3w	Domain	This is a domain of unknown function.  It is alpha helical in structure. The GO annotation for this protein suggests it is involved in nematode larval development and has a positive regulation on growth rate.	31.30	31.30	32.20	31.50	30.50	31.20	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.15	0.71	-4.49	80	1081	2009-09-13 10:17:57	2006-04-27 14:19:58	6	29	789	1	374	820	99	145.10	35	55.13	CHANGED	lhFap.pp......shuhhSNah.ps.h...........pl.....c..........s.......hp...asosEH........Ya.ApKhth....h..p........................................ppp...pIhp..up.....sPtcstp...............LGRp..ht....h+..W.pph+hplMhpushtKFpQ..pt.................c...L+phLLsT....GsphLVEsSshD....phWGsGhs.................................hpGpNhLGclLMcVR.ccLpp	.............................................................................Fat.t.......shushSpahs.t.s..h...............................ph..s........................................................u..............hp.....asosE+....................a..h.....ApKhh..........h...t............................................................tp...p........pIhp....ss........sPhp....stp...................hGRp.....hp..c....hp..W..pph+..pl.h....tcuhhtKFpQ......ps...................................c...L+phL..LuT....................u....st...hL....V....E.s....o......pD..............thWGsGhs.................................................hpGpNhLGhhLMclRcpL..t..................................................	0	172	262	347
+8553	PF08720	Hema_stalk	FluC_stalk; 	Influenza C hemagglutinin stalk	Mistry J	anon	pdb_1flc	Domain	This domain corresponds to the stalk segment of hemagglutinin in influenza C virus.  It forms a coiled coil structure [1].	21.60	21.60	301.20	301.10	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.18	0.71	-4.75	3	144	2009-01-15 18:05:59	2006-04-27 14:57:47	5	1	130	3	0	107	0	172.80	99	27.14	CHANGED	IFGIDDLIIGLLFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQ	IFGIDDLIIGLLFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQ	0	0	0	0
+8554	PF08721	Tn7_Tnp_TnsA_C	TnsA_C;	TnsA endonuclease C terminal	Mistry J	anon	pdb_1f1z	Domain	The Tn7 transposase is composed of proteins TnsA and TnsB.  DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The C terminal domain of TnsA binds DNA.	22.00	22.00	22.00	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.45	0.72	-3.97	38	303	2009-01-15 18:05:59	2006-04-27 16:28:33	6	4	250	4	69	203	9	78.00	24	26.68	CHANGED	EI..s.hhhcNlpaLhshhpppsstphpht.p.......lhphlpppss..psltslhpphs.t...........slptupsL..lttLlApchlthDl	...................................-l..sphhhcNIpalpsh.hcp.......ts..p...h...sph.ht.........lltpL..ptpst...sslpplhspl.................slssspulhhlptLlAp+hIpsDl...	0	20	36	51
+8555	PF08722	Tn7_Tnp_TnsA_N	TnsA_N;	TnsA endonuclease N terminal	Mistry J	anon	pdb_1f1z	Domain	The Tn7 transposase is composed of proteins TnsA and TnsB.  DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	25.50	25.50	25.50	25.50	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-10.10	0.72	-3.99	76	557	2012-10-11 20:44:44	2006-04-27 16:37:50	6	8	444	4	111	422	696	88.40	25	30.37	CHANGED	ssVhchc-Q.Pl.......................shphshp.Ghp+s.................hTsDaLlphpss.........t.hhhplK.........ppcLp....c....p+hhcKhph..........p+.pahpp.pGhsatlhTE	...................................sVh-lp-Q.Pl.........................shphs..pp.shp+...................hosDFLlshpss..........phhhlpVKs......................sp.clp................c........pchhpKhch......................t+.tahpt.ps.hpatlhs.....................................	0	23	62	83
+8556	PF08723	Gag_p15		Gag protein p15	Mistry J	anon	pdb_1hek	Domain	Gag p15 is a viral membrane-binding matrix protein which is alpha helical in structure.	26.10	26.10	26.10	26.60	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.72	0.71	-4.12	2	200	2009-09-11 06:11:00	2006-04-27 16:54:40	5	3	5	2	0	160	0	109.70	81	35.42	CHANGED	GDsLTWSKALKKLEKVTVQGSQKLTTGNCNWALSLVDLaHDTsFVKEKDWQL+DlIPLL-DVsQoLSGQE+EAFE+TWWAIoAVKMGLQINNVsDGKASaQLLRAKa.....sKKQuEssEtY	.....GDsLTWSKALKKLEKVTVQ.GSQKLToGNCNWALSLVD.LFHDTNFVKEKDW...QLRDVIPL...LEDVo.QT....L.S.G.QE+EAFE+TWWAIsAVKMGLQINsVsDGKAoaQLL.+AKaE+.+.su.s..KKQuEPpEEY......	0	0	0	0
+8557	PF08724	Rep_N		Rep protein catalytic domain like	Mistry J	anon	pdb_1m55	Domain	Adeno-associated virus (AAV) Replication (Rep) protein is essential for viral replication and integration.  The catalytic domain has DNA binding and endonuclease activity.	21.30	21.30	21.60	24.30	20.00	21.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.15	0.71	-4.75	9	213	2009-01-15 18:05:59	2006-04-27 17:04:03	5	2	57	9	0	219	0	158.90	41	26.63	CHANGED	hacsllp...........lSsNFlsasssphWp....uhhsL-ps-hPp...LTss-+lhshalschsshhcsPsu.....caFlQhEps..-phFHlHlllussslsshsl...ssplcsths+slachspPplsshFtsshoKK...Gt.phsu.saIssYLhPKl.Ppl.WuhTNlpEYthsC.sLphR+phhcpa	.....................................................................................................t.........lphsptlht.hLpphsph.p..tuP.......haFhQlEssp...EctaHlHlVlstssls.sRsl...hsp.lcshhs.phhhphhs.sh.lha..shTpp....G+haps...sppFI.NYLh.Kl..P..l.p.............ll.W.shTNID.t.ahssslSsshR+thhpt.h....	0	0	0	0
+8558	PF08725	Integrin_b_cyt		Integrin beta cytoplasmic domain	Mistry J	anon	pdb_1m8O	Domain	Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion.  Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit.  Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity.  This domain corresponds to the cytoplasmic domain of the beta subunit.	21.30	21.30	21.30	21.70	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.22	0.72	-4.57	33	606	2009-01-15 18:05:59	2006-04-28 13:40:02	6	34	134	25	288	512	1	45.40	48	6.09	CHANGED	KlLhplpD+REat+FE+E+tpu+WspucNPLY+sAToTap.NPsYtup	.......KLLhpIHDRREaAKFEcE+t.pA..KWcs.up.NPlYKsAsoThh..Nspapt.........	0	59	81	178
+8559	PF08726	EFhand_Ca_insen	efhand_Ca_insen;	Ca2+ insensitive EF hand	Mistry J	anon	pdb_1h88	Domain	EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes.  EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets.  This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties.  The calcium insensitive EF hand is still able to mediate protein-protein recognition [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.41	0.72	-4.00	23	640	2012-10-02 16:17:27	2006-04-28 13:56:49	5	73	193	3	326	1364	9	67.50	48	5.87	CHANGED	-psouEQlhpuF+tl.AssK.sYlTcp-L+psLsP-ps.-aClppMs.ap.......ssp...pps.su.aDYhuFspsLau	.......................-scTuEQVhsSF+hL..As.s...K..sYITt-ELR...+...p.........LsP...-.QA...-YClpRMsPYp.....................................GPc......usPuA.hDYhuFosuLat.......................................................	0	82	120	210
+8560	PF08727	P3A		Poliovirus 3A protein like	Mistry J	anon	pdb_1ng7	Domain	This domain is found in positive-strand RNA viruses.  The 3A protein is a critical component of the poliovirus replication complex, and is also an inhibitor of host cell ER to Golgi transport.	22.30	22.30	23.00	22.40	20.90	22.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-9.08	0.72	-4.63	21	1219	2009-01-15 18:05:59	2006-04-28 16:12:37	6	15	264	2	0	1300	0	56.90	55	2.66	CHANGED	GP..a+.lpIsl..csPPPsAIsDLLpSVDotEVRcYCccptWIVPt...psslERslNpA	.........GP..a+sl+Isl..psPPPsAIsDLLpSVDSpE.VRcYCc-pGWIlPt..ossplERclNRA....	0	0	0	0
+8561	PF08728	CRT10		CRT10	Mistry J, Wood V	anon	manual	Family	CRT10 is a transcriptional regulator of ribonucleotide reductase (RNR) genes [1].  RNR catalyses the rate limiting step in dNTP synthesis.  Mutations in CRT10 have been shown to enhance hydroxyurea resistance [1].	21.90	21.90	22.00	22.10	19.00	21.80	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.22	0.70	-6.54	9	141	2009-09-13 09:52:06	2006-05-02 12:36:21	5	8	105	0	106	153	0	320.30	15	55.24	CHANGED	hsPtchhhssh-phshpclhhp.ssppapsthplphhu............FKNNlhshhp....tsaLhlussoplhlashDslsshsph................hc..scsshsshhDc.hlSohP..saTINal.phssahGpphLssChDsGhlhhWhhsoIlp.hppa..........ps-.c.............th..psR...hplpPc...hpl+hcu...SsWuhDhh.sa.....sspslIssucNu....puloL..hhachs..c-RaYhtc....shp..............h.HNlPslSFlssp.sst.ha.lhVussoIsGplhohpFp...Fp.pps...............................................h.clphssshh.o+shhu-DsWTlpPlSscsFhpVsuhchlsss.pphpccpplppIhp-StlLss..s.s..os.hGhuAphp.apsPVssl..........................................................................................................................ps+pss...ppps...............................................................................................phpss+.oslc--a................................pplHctlcp.h....ph..tpcpps.G..h...........ps.hlhlTTs++lsLh+scsLhssuuTp.clFsLp..shsptscho....NRIShsphI.ELsChlsuSQ.GLlSlhRLspa+GlYuhRQEaIhs.....................................sspslshshtthpslshltl..............p-psh...h.hhhlYVsYssulh.sYcI	......................................................................................................................h......................................................................................................................................................................ptlN.h.hhs.h.........htp-hlhhshDsG.lhha.hptlht.hpph...................................................ts.....h....ht....SsWulshh........p..phlAsutNp............lsl..ahht.........ppt...........t....................................................................................tNlPslsFhspp........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h......................................................................................................................................................	0	18	54	90
+8562	PF08729	HUN	HPC2; HRD;	HPC2 and ubinuclein domain	Mistry J, Wood V, Balaji S, Iyer LM, Aravind L	anon	manual	Domain	HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription [1].  It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes [2]. Hpc2 is one of the proteins  of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone  proteins. the Hip4 sequence from SCH. pombe is an integral component  of this complex that is required for transcriptional silencing at  multiple loci [3]. HPC2, ubinuclein/yemanuclein, and the cell cycle  regulator FLJ25778 share a conserved domain that is predicted to  bind histone tails [4]. This domain is also referred to as the  HRD or Hpc2-related domain.	26.90	26.90	26.90	27.10	25.20	26.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.12	0.72	-4.10	54	344	2012-10-09 00:06:17	2006-05-02 12:49:19	5	6	246	0	236	333	0	52.80	40	6.69	CHANGED	pp+ccpch.c....tttYDp-DsFIDDoE...hh-Ehh.............hssppsGFalspGsLt.	..................t...tcpc..chhshshtYDpsDsFIDsSE...ha-Ehh.............hssptsG.FalssGsL...................	0	70	121	180
+8563	PF08730	Rad33		Rad33	Mistry J, Wood V	anon	manual	Family	Rad33 is involved in nucleotide excision repair (NER).  NER is the main pathway for repairing DNA lesions induced by UV. Cells deleted for RAD33 display intermediate UV sensitivity that is epistatic with NER [1].	21.70	21.70	23.90	35.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.06	0.71	-4.79	9	47	2009-01-15 18:05:59	2006-05-02 13:22:52	5	2	40	0	30	41	0	135.10	37	77.88	CHANGED	ht.ptpho..........+lPsElEDEILEtYuphot........ppDhsls-LPpaFcsLplPpsa...........Ychl+sc..clpl-uT.............................DIlDh-KLlpssh+LLhFhsN.opIcspWcLhlssuuc..tpshs.h.lpsahLol.DLpKlpsplshDps.	...........ps......p..........cls.ElEDEILEtYup.sh........-pDhslscLPpaFccLpl..sh...........achl+sc..slhl-uo.............................DllDhsKLlpsTspLLhhhsNhphIcc.WphllpssGc.ssshspstlcsahLol.DLpKlps.lshDpp.s...........	1	2	14	27
+8564	PF08731	AFT		Transcription factor AFT	Mistry J, Wood V	anon	manual	Family	AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis .  This family includes the paralogous pair of transcription factors AFT1 and AFT2.	21.60	21.60	21.60	22.40	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.69	0.72	-3.87	8	82	2012-10-02 23:28:20	2006-05-02 13:51:45	6	5	39	0	46	87	0	88.90	35	18.93	CHANGED	FcDKsDIKPWLQK.IFYPQGI-IVIERSDuhKlVFKCKusK+pcstsc........................................................................KKKpus....u+assCPFRVRAsYSl+pK+WolVVlNNsHoHsL	............................................................................Fps+p-l+salpc.hhhspGhtlVIt+Ssp.tlhFpCc.stphpt.t...............................................................................pctsho+h.pCPF+lRAsaSh+pptWslslhsstHsH........	0	10	31	46
+8565	PF08732	HIM1		HIM1	Mistry J, Wood V	anon	manual	Family	HIM1 (high induction of mutagenesis protein 1) plays a role in the control of spontaneous and induced mutagenesis [1].  It is thought to participate in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage.	28.70	28.70	28.70	28.70	28.60	28.30	hmmbuild  -o /dev/null HMM SEED	410	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.48	0.70	-6.01	4	31	2012-10-10 17:06:42	2006-05-02 15:48:55	5	2	30	0	20	61	6	330.40	38	90.90	CHANGED	LLhGuouLsGKhVhpphLcls.Ylssh.-L.phhLp....ulpphppNlhlppH.........................lhshsR.hhp..p......phh+o.sh.s........htshshpGSQa.......................a.pphpslthDl-plspo.sshs.a-s....ahKscsc..pths.huhhhthK....pasaslpYsouctchlplssshsVsQll.PcSppWPpllP.+IFo..spl-thsh.pc..hP.......ls-IpThISoLGSTSsRs++opsspsalDYhLNhslsKs.Fs....ssssKphlIsTSFNNhhlSps..YF+hKt+LEssLs.slss.LppLsILRPGPLlGcHGs.....PoNssl.c.sushLc+hhhYKKslhpphhpals-h+clGhsTKsSElVApshY+hPGuhllGYslPst+VAalhuhtA......lc+hh+pu..hhcVs..SSpphDshc	...............................................................hhGuouLhGphhLpphLp.phYlts..ppl.p.hhp.....shpp..h.tphhhpph.........................hhshsRp..p.p........hhp..ph.t........hpshshpGuca.............................................a.cphp..phc.hpphs.pss.sshs.acs.t..hhcssscp.pshsthShl..hp.K....phsapLpYsssctchlpIhhshsVhQllhscSppWPcLLP.cIFo.........tplcthshcp....cp....hhP......sLs-.IsTMlC..oLGSTSAcs++opsspsa.sDYhLsasLAQp.Fo......s......Tt.....sK+lVlsTuF.NNshlSphFpYFRhKuKLENDLcpsLs...s+LKcLVILRPGPhsGp....Hus.....Plssplt+...ssshL.p+hhha.+hhh.hphthhtph+phG.t.+ho-llAp.hYphPGs.hlGYslsst+su.hhs..u......hp........p.....cl...pS.phD...s..........................................	0	3	9	16
+8566	PF08733	PalH		PalH/RIM21	Mistry J, Wood V	anon	manual	Family	PalH (also known as RIM21) is a transmembrane protein required for proteolytic cleavage of Rim101/PacC transcription factors which are activated by C terminal proteolytic processing. Rim101/PacC family proteins play a key role in pH-dependent responses and PalH has been implicated as a pH sensor [1].	23.70	23.70	24.50	44.80	22.00	23.60	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.23	0.70	-5.61	24	159	2009-01-15 18:05:59	2006-05-02 16:21:54	5	2	116	0	116	156	2	343.90	28	55.16	CHANGED	sCpshtLssGhll.hsh.t........hphhhsAhapspCsts.........h.ssh....ph..................shppa....ppsppssFhhuhlsllaslusssVhsWhLslllhl....pP.................................ht....................tpshLh+luslhsulhhTlhlscshptlccp.h.pGhhcutpLhchlhsshshpllcllsshhhplsplQllhRlFsRp+cKph..................lhhlGhhlhlsspllaulsphp..ss..........tppstshlsshhhLhclultlhaAuhlhhYslpch.....................+hth...tt+phhhLsllolhllhl.lshFlhDlu....shhltpWuchlshlhtlhssVlsWEWls+lphlE+ctc+puVLGR+l.c.D-hhphc.s....ps	................................................Cpsh.Lss.Ghlh.h.s.t..........hshstsuhat...Csts...........s....................................s.tth.......s...hp-sF..hShhshhaulusssVlsahLslllhl....oPp..................................................shs..t+.shL.+lusLhsAlslTlhhscoh.pshccQat.hG......h.cuptlpsplh...........sshph+llclloshhL.lsQlQhlhRLFs.Rp+-Khh..................IhasGhhLhl.hsslh.slspFh..sst.................spphhsslsshsYLhcLulshlYAuhllaYshpK+..............................................................................+hsa.....th+phhllslLollslllslsFFl.hDlu....p..lssWu-hhpalstssuoVlVWEWlp+lEtLE+cccKculLGRcla-..D-hhchs.t..p...................	0	17	54	98
+8567	PF08734	GYD		GYD domain	Bateman A	anon	PSI2 target	Domain	This protein is found in a range of bacteria.  It is usually less than 100 amino acids in length. The function of the protein is unknown.  It may belong to the dimeric alpha/beta barrel superfamily.	25.20	25.20	25.30	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.64	0.72	-4.26	39	239	2009-01-15 18:05:59	2006-05-02 16:35:35	6	2	184	0	114	254	1015	90.70	27	86.84	CHANGED	YlslssaTspGhcsltcs..scRtcAscphlcs.hGGplcuhahohGp.YDlVslsEuP.DssssuthuLsluutGsV+o.pTlpuhs.s-hpchlt	..............................alhlhsaTspGhcsltcs....scRhcss.pphlcp..h..Gsclc..shYhs.hGp.aDhlslsEuP.Dstshsthu.ltlsutGslco.cThpAhsh--htphl.t....................	0	30	67	88
+8568	PF08735	DUF1786		Putative pyruvate format-lyase activating enzyme (DUF1786)	Bateman A	anon	PSI2 target	Family	This family is annotated as pyruvate formate-lyase activating enzyme (EC:1.97.1.4) in UniProt. It is not clear where this annotation comes from.	25.00	25.00	31.20	81.50	22.30	21.50	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.81	0.70	-5.21	15	82	2012-10-02 23:34:14	2006-05-02 16:42:18	5	1	81	0	47	80	5	247.50	34	72.86	CHANGED	MGGGPlTtAl+cHlcpGhcVhhT.pAAhTl+DDL-+V+uhGIpIs--s.........sssslphtDlDhttlpshlusasl-hshs..lulAVQDHGhuPs.hSsRhaRFc.hh+chL.ppGsp.-cFla..c-sPpt..aoRM+Alhcslccsshtt....hlMDTs.sAAlhGuLp-sch....shpshlllslGNGHTlushl.ccs+IpGlFEHHTshLssp...KLpphlc+hssGcLosEElasDGGHGAal.....suhspscslllTGP+Rplh	....MGGGshstAlppHlptGhpVhso.pAAhTlcDDL-cV.+.s.hGlpIsccs...............ssstlhhtDhDhthlpshhsshulchs.p..lslAsQDHGasss.tSsRhhRFp.hhcchL.pp...........ssp.tshha..pcsPp...hoRhpultcsltts............hlhDTu.sAAlhGsLt-spl...pttpshlllNlGNuHTlushl.pss+IhGlFEHHTuhlssp...cLtphlc+hppGpLssEEVas-sGHGuhh.........tths.thc.lhlsGP+Rph.h..	0	18	37	43
+8569	PF08736	FA		FERM adjacent (FA)	Baines AJ, Finn RD	anon	Manual	Family	This region is found adjacent to Band 4.1 / FERM domains (Pfam:PF00373) in a subset of FERM containing protein.  The region has been hypothesised to play a role in regulatory adaptation, based on similarity to other protein kinase substrates[1].	28.70	28.70	28.90	28.80	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.15	0.72	-4.16	44	1186	2009-01-15 18:05:59	2006-05-03 11:03:47	6	34	97	0	506	928	0	46.50	43	5.71	CHANGED	sphh..shGS+FRYSGRTptQshctspp..htRps.pFpRs.Spptsppps	........pFh..shGS.+FRY....S...GRTptQshcsuph..htR.sspFE.RssSK+hspp................	0	80	119	275
+8570	PF08737	Rgp1		Rgp1	Mistry J, Wood V	anon	manual	Family	Rgp1 forms heterodimer with Ric1 (Pfam:PF07064) which associates with Golgi membranes and functions as a guanyl-nucleotide exchange factor [1].	31.00	31.00	31.00	31.10	30.40	30.40	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.22	0.70	-5.40	30	392	2009-01-15 18:05:59	2006-05-03 12:51:38	5	4	255	0	271	363	0	254.90	21	59.05	CHANGED	psLhhuasQIpGphplstshls....sshpt.ppp..hht..........................tt.tp.tp.t..............h.phh.sssphstshsthhststpss................................................................................pcslPlhoTPpolLFsDLpLsPGEoKoFpa.shsLPpsLPPSa+.Gps.........l+lpYsLslGspc....................sttsppsptlplPlRVhs.hptt..................h.tsl.pshhhlccptplphhssppptsssshht............................spcss..........pphpphhchlppLlspcs.p....................p.p...........................................................................tspapIspsscpluplsLsKshY+lGEslshsl-hssss....htshtlsssLEopEp.................lssph..............................tlpusspspp.............sstpshsppppsshpsp.plshplsIPhssT....PpFpTshlp.....LcWpL+FcFVhsp	.............................................................................................................................................................................................................................................................................................................Lhsph.l....sp...........p.a....h.p..lP........hPsoap.uts.........hph.Y....l..hluhph..............................hplPhplh........................................................................................................................................................................................................................................................................................................................................................................t.aplt..stthlshh.h...cs...h..at..hG-.l.hhhpht.tt...................h.shth.pstLps..Eh.................................lt.th..................................................................................h.hhsp..t.sh..h.ph.h..slPhpss....sth.....Ts.......hhp...........hpW.lphcFhh..t.........................................................	0	83	135	213
+8571	PF08738	Gon7		Gon7 family	Wood V, Bateman A	anon	Wood V	Family	In S. cerevisiae Gon7 is a member of the KEOPS protein complex. A protein complex proposed to be involved in transcription and promoting telomere uncapping and telomere elongation [1].	21.80	21.80	22.10	21.80	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.39	0.72	-4.03	18	104	2009-01-15 18:05:59	2006-05-03 14:02:37	5	1	102	0	75	92	0	97.40	31	80.47	CHANGED	l.sAsYouPsssp.csFchshs.P.........ot.Sths.pAuspsp-csocsKs.............sYLucLRspLosLQDcINhFLTpRMEc-Kpttttputt.t......p-cpEcchhs	.............................................hA.YpuPs..p..ppFt.t.s.s......................su...t.s.psp.sops.+s.............sYLupLRstlssLQ--INpFLTpRMEc-Kpcptt.tutttp..........p-pc-cc.hs.....................................................	0	11	35	63
+8573	PF08740	BCS1_N		BCS1 N terminal	Mistry J, Wood V	anon	Pfam-B_10126 (release 19.0)	Domain	This domain is found at the N terminal of the mitochondrial ATPase BSC1.  It encodes the import and intramitochondrial sorting for the protein [1].	22.40	22.40	22.60	22.40	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-4.68	55	539	2009-09-16 12:49:40	2006-05-03 16:25:19	6	9	253	0	410	534	1	175.50	25	35.62	CHANGED	hhlGsshuhh+phhphhhph.....hpcphhsolElss.....cDcsYsallpW.huppshsph.pp..ht..t....................................................phthpsphtpcp.................ppphpasPu.G.sHahhYcG.p..hltlpRp+.pppthshss.t.s.........hEslsloslupstplhpcLLpEA+phhhpppcu+..TllYputusp.........Wpp.stsRtpRPlsoV	...........................................................................h.hhusshthh+pshphshth.....hpcphhsol-lss.....cDc.sYsal.lpW.lsppsttp..t...pp..ht.............................................................t.t.h.p..sph.pcp.....................psphpahPu.G..pHhhh......Ycs.p..alhlp...Rp+..ppp....hshts...s.s................hEsloloslup.s....pp....lhpclLpEA...+p..hsh.pppcu+..TllYpuhusc.........Wp..stsRtpRPlsoV...................	0	114	215	349
+8574	PF08741	YwhD		YwhD family	Bateman A	anon	PSI2 target PSI-blast from BH3813	Family	This family of proteins are currently uncharacterised.  They are around 170 amino acids in length.	25.00	25.00	81.10	80.80	20.90	19.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.97	0.71	-4.84	13	388	2009-01-15 18:05:59	2006-05-04 13:58:48	5	1	383	0	44	165	0	163.10	67	96.27	CHANGED	KKp..huFNIIKsDsTDGHGGaGsGoLSL-NVSPVhlDlE-pcAFVDlGAMHARSsVEKtIKFlss+--Vs..sGK.YWLVWVTl-RpE-GPYYAGVTACEMsVs+EhRR...GYKSLPEHVN+MDKSlK++IlV-HMD-sSKplLu-FLcsHs.sMWp+Ss-EL+cuLt	..............KKshsFNIIK.NDPhDGH+GhslGSlSLDNIuPVFIDVtsKEAFlDIGuMHARucVEKGlKalT-KstV...puKtYWLsWVTsERsEp.GPYYAGlTAC.hhVs+sIRR...GYKShPEHVNhMDKSMK+HIIlDpls-csKtlL+-FLhsHsEuMWpcSS-tL+pAh.p...	0	14	27	36
+8575	PF08742	C8	DUF1787; 	C8 domain	Mistry J, Liu XH	anon	Liu XH	Domain	This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.  It is often found on proteins containing Pfam:PF00094 and Pfam:PF01826.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.93	0.72	-3.73	131	2979	2009-01-15 18:05:59	2006-05-04 14:10:28	6	390	118	0	1758	2535	1	74.30	30	11.28	CHANGED	pttspphCphlh.sst...FspCHshVsPpsahpsClhDhCt.....stss........psh.CsslssYApsC..pptGlslp..WRs...shCs	.........................................t...spphCshlh..sss..........Fts.CHs..h..V...s.P.p.s.ahcs..C..lhDhCt...............ssss............p...psh.C.sul...ssYApt.C......p.p...t..G...l......s...lp.....W...Rs...shCs..................................................	0	299	442	1045
+8576	PF08743	Nse4_C	SUMO_ligase; Nse4;	Nse4 C-terminal	Mistry J, Wood V	anon	manual	Domain	Nse4 is a component of the Smc5/6 DNA repair complex.  It forms interactions with Smc5 and Nse1 [2]. The exact function of this highly conserved C-terminal domain is not known.	19.60	19.60	19.80	19.90	18.20	19.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.07	0.72	-3.96	24	357	2009-01-15 18:05:59	2006-05-05 09:24:19	5	11	270	0	259	358	0	89.00	29	23.74	CHANGED	pslshhcFVlNP...pSFuQTVENlFalSFLl+-GtspIphc.pcslPhlps..t.s.tsstspstsst+pQuVhslDhcsWcphlchasI..pEshlspc	...........t.slshacFllsP...pSFupTVENlFalSFLl+DGplplphD.....pc.s....l.......Phlps...........t..s..........ts...p......t......hp........p................pshtppQh.lhslshpsWcphlc..hapl..pcshl.......................	0	83	137	208
+8577	PF08744	NOZZLE		Plant transcription factor NOZZLE	Mistry J	anon	Pfam-B_86265 (release 19.0)	Family	NOZZLE is a transcription factor that plays a role in patterning the proximal-distal and adaxial-abaxial axes [1][2].	20.20	20.20	20.30	21.00	19.40	19.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.26	0.70	-5.06	2	13	2009-01-15 18:05:59	2006-05-05 10:55:01	5	1	7	0	9	13	0	216.80	34	57.38	CHANGED	MATSLFFMSTDQNSVtNPN-LLRNThLV...sGEIRTE.shKSRGRKPGSKTuQQpQKcPTLRGMGVAKLER.hhEEEKKph.ssAs.GDTS..Au.sNsATRhP...D.GVVLQGFPS........SLGu...sRhhCGGsGSGQlMIDPVhSPWGFVETSu..HELSSIsNPQMaNASSNp.CDTCFKKKRLDGDQ.NVVRSNGGGFSKYTMh..PPPMNGYDp.LL.sD..QRSQGFhYDpRIARuA..sAuSsohNPYFNEATNhTG.shEEFGSh...NPRNGotGVKEYEFFPGKYs-hhuhsh.suo.VGDCSPN...TIDLSLKL	........................s..........................................h.p.shpoRuRKssoKpupppQKK.s.RGMGVAQLERlRIEEcpKph.shAs...us.....sS.........hp...s.phsp.s...s.G.s...............................G....sh..s.uhGuG.hhlsPhhs...s.t.st..st......+ELSShsp.........p.CDhCFK................................................................................................................................................st.............................................	1	2	8	8
+8578	PF08745	UPF0278		UPF0278 family	Bateman A	anon	PSI2 target MJ0950	Family	Members of this family are uncharacterised proteins about 200 amino acids in length.	22.50	22.50	22.50	22.50	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.46	0.70	-5.08	11	103	2012-10-03 20:43:45	2006-05-05 13:00:30	6	2	91	1	79	113	3	182.50	35	88.86	CHANGED	RFVLDTosFT-splRcthG.cslsEuscphLDLIucARlphsISCYlP.PoVYpElppFhcp.ssstElls+l-TWllKKoPsRYEl+IPAplFYEYlc-lRcRls+GhRlAEctlh...Euuspsh............cpp...-.lGclIschRcKYRpsLRpGhLDSs.DlDVLLLApELDAuVVuuDpGIc+WA-+LGLRalsussFPphLcEYLch.	..............................................................RFlLDTohhsssplRp.hG.ps.scuhpphlclhtpsch.htlphahP.solYpElhthhp.....tclhscl-hallhKsPs+aplpIPu.lhYEalc-hRpRls+GhRluEctlh...cus.ts................................p.lsphIpphRc+YRpALRp.GhLD..SptDlDlLLLAhELDAslVosDtGIppWAc+lGl+alsutpF..hLcphlp.h..............................	0	19	42	61
+8579	PF08746	zf-RING-like		RING-like domain	Mistry J, Wood V	anon	manual	Domain	This is a zinc finger domain that is related to the C3HC4 RING finger domain (Pfam:PF00097).	22.90	22.90	22.90	23.20	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.95	0.72	-3.96	12	210	2012-10-03 15:03:13	2006-05-05 13:42:37	6	5	176	2	141	204	0	43.10	37	14.10	CHANGED	CphC+clshpG.tCss.sCshc............hHhtChppahpppss..hCP...sC	...CphC+cllhtGppCs..s...pCsh+...............hHh.Chp+aapppp.....t...pCPpC.......	0	27	60	102
+8580	PF08747	DUF1788		Domain of unknown function (DUF1788)	Bateman A	anon	PSI2 target Npun02004481	Domain	Putative uncharacterised domain in proteins of length around 200 amino acids.	21.80	21.80	22.10	22.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.50	0.71	-4.27	24	273	2009-01-15 18:05:59	2006-05-05 16:38:57	6	1	261	0	68	239	41	125.00	30	65.39	CHANGED	lhclsLa-lsl-lLc-Rtlh-cllchEpppGp-tlhctLpulLc.......pcclsptIscp.htstshDllhLoGVGpsaPhl.RoHslLNNLpshhtppPllMFaPGpYs.....GpsLcLFsplc--s...YYRAFpll	...........................................h..phslaplhl-hLpc+..s.......h..h.-...p.....hhp....hE.p..h....Gt...-tlhc.tlps.Lp................pcclsphIsc+....h...t......h..s.s.ps..lVhLTGlGpsaPhl.RuHplLssLp..s..hhs.psP..llhFaPGpYs.....GpsLplFs....phcspN...YYRAFpl.........	0	30	49	59
+8581	PF08748	DUF1789		Domain of unknown function (DUF1789)	Bateman A	anon	PSI2 target CAE43632.1	Domain	Putative uncharacterised domain found in phage-related conserved hypothetical protein from Bordetella.	21.10	21.10	21.30	21.80	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.51	0.71	-4.04	16	124	2009-01-15 18:05:59	2006-05-05 16:46:41	6	4	104	0	23	102	2	103.00	28	77.82	CHANGED	MA..KhsL.........utsP.TF+hsVplshhsGpsscl.F.............TFKah..sppElt-lhppts....................pp......................................ss-hlpplssGWs.l--cFs-ENlphLlspasuAspAllsAY.pAlstsRlGN	....................................................Mu...hhpL..........spP.TFchsVpIPhsGt.css..l.ph.............sF+ah..shp-ht.ph.p..t....................tt........................................sh-hhhchlpGWs.......l-..-.....sFscENlphLhssYPt.AspAlhssYhptlhssRttN............	1	1	11	19
+8583	PF08750	CNP1		CNP1-like family	Bateman A	anon	PSI2 target CAB84161.1	Family	This family of proteins are likely to be lipoproteins. CNP1 (cryptic neisserial protein) has been expressed in E. coli and shown to be localised periplasmicly [1].	25.00	25.00	77.60	77.30	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.78	0.71	-4.49	22	187	2009-01-15 18:05:59	2006-05-05 16:59:41	6	1	186	0	53	147	10	146.50	39	75.01	CHANGED	..h.pstsWcEtps.tLP.shPpspsLlsFsV....ussos.pFhlDscSloVG.sDGVVRYslVlsSsuGA+NVsYEGIRCsoh..........Eh+hYAthsss.spWstsppsp....................Wptlpss.shNpapusLhp-aFCssts.ssts..sspllpsL+s	..................sttppacEpps.pLP..PLP..psp..shl.Fsl....s.sss.+ahlDupSlslu.sDGlVRYhlllpSss.Guc...NlsaEGIRCs.sh..........ca+hYAhhssspspW.pspps-....................Wp.Itss.shNshttsLhpphFCpsth.Psts..spsllppl+...............	0	9	30	41
+8584	PF08751	TrwC		TrwC relaxase	Mistry J	anon	pdb_1omh	Domain	Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer.  TrwC binds to the origin of transfer (oriT) and melts the double helix.	22.80	22.80	23.00	23.30	22.30	22.70	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.93	0.70	-4.99	34	741	2009-01-15 18:05:59	2006-05-08 13:13:30	6	26	467	20	202	783	45	275.90	33	24.11	CHANGED	thpssusussYYpsps.....................sYYt......pspssspW.hGpGupp.......L..........GL.sGpl..s.ppphtpl......l.sGphP...........sGptlsps.t....t.....................................................................................................psGaDLTFSAPKSVSllhhluuD...ccll.pAHppAVstulph.lEcphu.sRtsppGp....th.pss.sLlsutacHcoSR...........st.........DPpLHTHsllhNhs........................................hssDG....pWRoLsuc..............placpphthGtlYpupLtpcl.ccLG..aphc.........cpGsaEltGls.pchlctF..SsRsppIcpthuc.u.............ssstttcph......AshsTRpsK.pps.shsplcptWppcupph..Gh...-h	...........................................................................................................................................t....ttuhtYatpp.................................sYYs............sp....stpW..hGpG....Apt...................L.................GL..pGps.....s.pp.h..ppl........l..p.Gp.hP....................................sGtp..l...s...p..h..............tt.....tp......................................................................................................................................................................................................psGa.DLTFSAP.KSVSh....h..........th..l...........usD...............c.......plh.pAHppAVp.s........lp..lEp...h...u....s.Rhtps..Gt.........th..Ts.sLlhAhFpHcTSR............................st.........D.....PpLHTHsllhNhs..........................................p..t.s.G..........cW+..s..Lssc..............sla.tp.phsh..utlYps......p......Ltpp......l.ctlG...aph..c.............cps....h..aEl..........sGls...........t...................l-s.F..SpRspp.....Iccthsp..........................................ssshpt+ph............AslsTRpsK...p...ps......s.p.hhtpWhpphpph..Gh..h........................................................................	0	61	144	184
+8585	PF08752	COP-gamma_platf	Gamma-COP;	Coatomer gamma subunit appendage platform subdomain	Mistry J	anon	pdb_1r4x	Domain	COPI-coated vesicles function in retrograde transport from the Golgi to the ER, and in intra-Golgi transport.  This is the platform subdomain of the coatomer gamma subunit appendage domain.\	      It carries a protein-protein interaction site at UniProt:P53620, residue W776, which in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2 [1].	25.00	25.00	25.20	25.00	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.73	0.71	-4.40	81	438	2012-10-03 16:25:20	2006-05-08 13:33:25	5	10	295	2	300	436	6	145.80	42	17.35	CHANGED	ppppYsppLusIP....cht....sh.GslhKSS.p...slpLTEsETEYsVsslKHlF..ppHlVlQFslsNTLsDplL-sVsVhhsss...-st.......h..pphhhlPlspLs..h.spsGssYVshpt.....s.sshshusFus.sL+FhsKE.lDPsTG.-s--....-GY-DEY.lE-lElss	...........................................t.tphatcpLutIP.....Eht...sh...GsLhKSS.s....PVpLTEuETEYsVpslKHl.F..spHlVh........Q.......FcssNTL.....sD...plLEsVoV.hpss...-s........a..p.hhhlPstp.Lsh..s.pPGtsYlhhph..............s-.ssh...........sssoF...us.sLKFssK-.sDPsTG....Es--.....-GY-DEY....lEDl-ls.h.......................	0	101	159	238
+8586	PF08753	NikR_C		NikR C terminal nickel binding domain	Mistry J	anon	pdb_1q5y	Domain	NikR is a transcription factor that regulates nickel uptake. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel.  This domain corresponds to the C terminal regulatory domain which contains four nickel binding sites at the tetramer interface [1].	20.90	20.90	21.30	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.42	0.72	-4.09	39	1066	2012-10-02 00:29:19	2006-05-08 14:04:46	6	4	979	79	297	602	67	78.40	43	56.69	CHANGED	sGslsllYDHcppsLspcLsslQHcapcl.....IloohHlHLDccpChEllll+GpupclpcLucclhuh+GV+au+Lshsss	......................uVLohVY-H.c.pR.-Lup+lsshQHcHHDl....sluTLHVHl....s....H.-c.C.LElhlLKGchu-Vp+hADclhAp.RGV+HG+Lpslsp..........	0	76	181	243
+8588	PF08755	YccV-like		Hemimethylated DNA-binding protein YccV like	Mistry J	anon	pdb_1bvb	Domain	YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression [1].  The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.41	0.72	-4.07	64	1071	2009-01-15 18:05:59	2006-05-08 14:58:45	6	15	964	1	318	578	1189	98.80	44	47.48	CHANGED	puKFpIGQlVRH+hasaRGVlhDlDPpFsso--WacsIst-h+..Pt.+cQPFYHlLsEscps.............phl.uYVuEpNL.....h.DssspslcHPpl....schFpphcsu..tYh.c	.......................s.uKFuIGQ.V...R.Hp..........Lh..G..Yh....GVV........l......DlDP..a..u..hsE..........-p.....ls.........ss.c..............ph..RstP......aYHV.lhED-.su.............................V..sYlAEtpL........ps-hpsE.cscpPsh....-Elhpshcpp..h.ts.+.....................................................................................	0	90	160	239
+8589	PF08756	YfkB		YfkB-like domain	Bateman A	anon	PSI2 structural target yfkB	Domain	This protein is adjacent to YfkA in B. subtilis.  In other bacterial species it is fused to this protein. As YfkA contains a Radical SAM domain it suggests this domain is interacts with them.	25.00	25.00	25.80	190.60	20.20	17.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.95	0.71	-4.64	14	371	2009-01-15 18:05:59	2006-05-08 16:01:15	5	6	371	0	42	183	0	153.50	70	40.66	CHANGED	MYPuDFASsLEsLSLcEhRcAIH+LLDhRDcslWMLFGTLPFYPCSssEEDhcLL+RLhpppNVTVRNDPDGRSRLNVNIFoGslIVTDFGDp.PsLGNIps-sLs-AYs+WppoclA+pLNCHCPuVpCLGPNVLVKNsYYp-sDFpp+pA+l	MYPuDFASpLsVLTLAEM+csIHclLDhRDEslWMLFGTLPhaPC.cD--DQ+LLpRLRpuKNVTsRNDPDGRSRLNVNlFTGNVIVTDFGDE.ssluNIQcD+LsDVFDKWL.u.ScLAKSLNCHCsphpCLGPNVLVKNMYYPshDF+cpctp.h..	0	12	25	34
+8590	PF08757	CotH		CotH protein	Bateman A	anon	PSI2 structural target cotH	Family	Members of this family include the spore coat protein H (cotH).	24.60	24.60	24.60	24.80	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.02	0.70	-5.19	53	707	2009-01-15 18:05:59	2006-05-08 16:09:44	6	49	471	0	258	662	798	299.10	19	51.59	CHANGED	l+hRG..so.......opph.sKKSa+l....c.hcpt..............th.Gh............cchhLpspatD..sohhRspluhclhcph...........uhssspsp.....asp..lalNG.........cYhGlYhh..hEplc.cphlctc..htsss.........utlacss................t..sh..t...ptth........ppssptshsplhs.hlphlsss....s.tphtstlpphlDl-salcahshptlhsNh...D.sh....scNhaLa..............tspss+aphlP.WDhDtuauphhp............................................t...thh.hsttssLh..p+llps..ssa+pphppphppll..pshhstptltshlcshtshls..sthpp-stthtsht..........................phppphphlppalppRhpal	....................................................................................h+G..sp...............t..t..h...+p......sacl...........p.hpph................t.h.Gh................cphhLp.s.....t.h......D...............oh.hRptlu..hphhpph.......................................sh...s.sps.p......ast.....lhlNs......................................ph.GlYh......hEp.lc..cphhc...tp.....hhs..ss.........................................uhhaphs...............................................................................tt.sh.......tt.........h............................p.t.ts.......pp..s.....hptl...p..hlphhsss........................ttth....ptltphlDl.-.p.hlcahshp.hhtNh......D.sh............spNhhla.............................ttpsshap....hlP..WDh.-hsautt.t.........................................................................................................................thh.t...t...ss.Lh...tpllp......stappthpp.h...hpc.lh..........p..p......h..s....phh.sh.l.pphtphlt......s..h..p.s....h.h..h.............................................................thpt.tht..l..phhptR.t...........................................................................................	0	146	211	244
+8591	PF08758	Cadherin_pro		Cadherin prodomain like	Mistry J	anon	pdb_1op4	Domain	Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion.  They are activated through cleavage of a prosequence in the late Golgi.  This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions [1].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.86	0.72	-4.21	52	421	2012-10-03 16:25:20	2006-05-08 16:13:35	6	13	48	1	158	409	0	82.30	30	10.07	CHANGED	sCpPGFppcsashplspc.lpcGp.L........hpVpFssC.sGpp+lpYpoo-s.cFKVssDGolhstRslplpscphpFhVaApDspscc...............hslpltl	...................................p.h..h...lspp....l.ttp.l........hp...VsF..p-C..ts..ppplta..pSSDP.cF+VtpDGolassRslh..L.s....s..cp.....t..s.FhlhupDspspc....hpltV..l.....................	0	7	17	64
+8592	PF08759	DUF1792		Domain of unknown function (DUF1792)	Bateman A	anon	PSI2 structural target AAO75156.1	Domain	This putative domain is probably missannotated as a glycosyl transferase 8 family member. This domain is found at the C-terminus of protein such as Swiss:Q97P75 that also contain the glycosyl transferase domain at the N-terminus.	20.80	20.80	20.80	35.90	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.44	0.70	-4.74	19	183	2009-01-15 18:05:59	2006-05-08 16:19:41	6	4	170	0	25	154	14	215.50	52	33.74	CHANGED	VsRFGDGEhsll........tGcsIsaQsa-scLAp+L+cll.ppscp..shlVCLPDsFp.sltcYsphuppFW+sahhhhsshapchh.....ssphYusTFlSRPYhDhtD....KspustaFccLKpIWcs+DlLIVEGtpSRuGVGNDLFcNs+SIcRIlCPu+sAap+hccIhptlpch.....ucs+LILlhLGPTAKVLuaDLtchGaQsIDlGHIDoEYEWa+MGAppKVKl.ppKasAEhN	.........llRFGDGEhsLh........hG.psIsYQsaD.ELAppL+cll..th..pSsE...cLlVCLPD.s.Fc...sh.pas.hupsFW+.pHh..hah-hYpcls.....pusaYGSTFISRPYI.DhcD....Kop..utuhFcKLKplWcsRDlLIVEGhsSRSGVGNDLFDpspSl+RIICPS+NAYSpl-pIpptlh.ca......Acs.+LILhMLGPTAKVLuYcL.s.phGY...QslDlGHIDSEYEWh+MGAppKVKh.uHKHTAEaN...........	2	4	11	17
+8593	PF08760	DUF1793		Domain of unknown function (DUF1793)	Bateman A	anon	PSI2 structural target AAO78587.1	Domain	This presumed domain is found at the C-terminus of a glutaminase protein from fungi [1]. This domain is also found as a single domain protein in Bacteroides thetaiotaomicron.	19.40	19.40	20.00	20.70	18.10	19.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.04	0.71	-4.39	37	301	2009-01-15 18:05:59	2006-05-08 16:38:11	6	11	161	0	170	307	0	170.00	37	23.78	CHANGED	lGltAhuclAshhGcstsAppYsslAcphhscWt.phuh....-us.......HhpLsa.sp.uoWo.hYNLhhD+LLsLs.........................................................lhPpplachpssaYhohppcYGlPLDoR+s.YTKoDW.hasAslussp.shpthlsslhpalsETsochPhoDhY-Tp..sGshss........FhARsVVGGaFhhLhh	................lGltAhuplAphhG...p.p....ssA.ppYpshAcphsscWp.phuh....-us.........Hh.+Lsa...cp...s.oWophYNLh.hD+LLs.Lp....................................................................lhPppVhptpssaYhs....h....p..pp...YGlPLD.......oRc.p.....Y...T.KoDW.hasAuhussp....shpphlsslhpahNETsochPhoDhapTp..sGphss..........FtARsVVGGaahhlh....................................................	0	67	109	144
+8594	PF08761	dUTPase_2		dUTPase	Mistry J	anon	pdb_1w2y	Domain	2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23).  Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms [1].  This family contains both dUTPase homologues of dUTPase including dCTPase of phage T4.	23.00	23.00	23.00	23.10	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.25	0.71	-4.16	34	876	2012-10-01 21:36:44	2006-05-08 16:42:01	6	2	693	18	118	593	126	152.60	27	88.39	CHANGED	sLpplhchQctLspclspcp.......pt.ph......hh.pp..hAlhsEluEhhsch...........tsaKaWKspp.............scttp...............................................lh.EhVDslHFllSlslphthp..........................................t.hs.ph.pt............hh.......phhtphpphhpp..st...pht.lhsthhtls.hlGhs.--lhctYhtKNplNatRQspGY	..................................LpphhplQcchscclstpp.............p..p.................h...h..huhhlEhuEhhsph...........p.s.aKhW.Kpps............spsh-s.........................................................hlpEhlDhlHF..h..LS.lslphhhppp.......................................tt..h......shhpp............................................hh............phhtp.h...p.h..h...tp...s...........ht...hht.a..htls.h.t.ht.......ash-plhcsYhtKtthNatRQs...........................................	0	41	92	106
+8595	PF08762	CRPV_capsid		CRPV capsid protein like	Mistry J	anon	pdb_1b35	Domain	This is a family of capsid proteins found in positive stranded ssRNA viruses such as cricket paralysis virus (CRPV).  It forms an all beta sheet structure [1].	21.10	21.10	21.20	21.20	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.31	0.71	-4.88	7	192	2012-10-04 01:49:40	2006-05-08 17:16:02	5	14	36	2	0	153	0	163.40	32	24.60	CHANGED	o..s.h.hhhGEplsslRpLl+RFphh.t......ptsssl.chsplppPt............tst.shshh.......shhualYtFaRGuhRaKlhshps...................t.....s..lshhtTsspsspsssuh............hh.sslpshtEhplPYYu.....Psss.s.ts.s....psl...psh.s.sltpt.psp.......sthhhRA.uuDDaoFuhLlGsP.h.hssup	..................................................................tsh..............................................................................................................h...............shluphYthYRGGlRhKllscps.........................................l.c.hsp.ss.s..sspps.hsSc........................s.tlp.hslpsVtEhplPYYu..........Pshoso..pups..................ph.....pGt..s..s..hslssss.suh.................sph..h....slu.AGDDhsFShalGsP.h..t.s................................................	0	0	0	0
+8596	PF08763	Ca_chan_IQ		Voltage gated calcium channel IQ domain	Mistry J	anon	pdb_2be6	Domain	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential.  The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1].  The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).	20.70	20.70	20.70	21.40	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-7.80	0.72	-4.71	25	724	2009-01-15 18:05:59	2006-05-09 09:54:38	6	7	96	16	235	602	0	34.30	52	1.83	CHANGED	sD-VTVGKFYATaLIQDYFR+FKp+Kppptpppps	.....DElTVGKhYAoaLIpDYFRpaKp+KEpthht...s.....	1	33	56	116
+8597	PF08764	Coagulase		Staphylococcus aureus coagulase	Mistry J	anon	pdb_1nu9	Domain	Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages.  The resulting complex directly initiates blood clotting.	20.70	20.70	20.80	20.70	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.89	0.70	-4.47	11	424	2009-01-15 18:05:59	2006-05-09 10:55:11	5	11	168	6	3	229	0	256.90	41	46.40	CHANGED	TKDYStcSpVNcsSKpGosISstYaWuhIcsLEsQFspAlcLlEcYpYGEKEYKDAKDKLMTRILuEDQYLLEKKhspYEhYKchYKKaKcpN...Ppsp.hKMtsFacYslYsLTMcEYN-IppSLK-Al-cF+p-Vc-IppKNpDLKsYsccpEcKATccVYDLVsElDTlasuYauDppaspcAKELRAKLDLILGDpcsPpRITNERI+KEMhcDLNSIIDDFFhETsQNRPssITKYDPshHDY+...-NKpsFDALVKET+-AVscADESWKsKTVKKYG	................................................tK.st.hss.hh.thlp.tLts.hh.uhslhc...p.cYs-.EYK-AhDKhhp+..lhuEDphL.p+hhtthc.hKcaapptpp..........tp.hph..hp..hcphs....lhsLThccYsplapoLKcshc-Fp+EVccIppKNsDLKs.a........s........cs...c-p+...As........scl..c..L.scl.h.l.....shs.aa....sc..p....patccsc-LhuKL..DLILG...-...pc...c...s....+.+.....h...TNcRhtcEhh-DLpoIID-FFh-hppNRPpsIsph.sss.c.H.s.p....cN+tNh-pLhp-TctAh.tcuD-Sh+p+psK.......................................	1	2	2	3
+8598	PF08765	Mor		Mor transcription activator family	Mistry J	anon	pdb_1rr7	Domain	Mor (Middle operon regulator) is a sequence specific DNA binding protein.  It mediates transcription activation through its interactions with the C-terminal domains of the alpha and sigma subunits of bacterial RNA polymerase.  The N terminal region of Mor is the dimerisation region, and the C terminal contains a helix-turn-helix motif which binds DNA.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.32	0.72	-4.27	17	765	2012-10-04 14:01:12	2006-05-09 12:02:26	6	4	521	1	130	526	7	97.00	22	79.65	CHANGED	s+hP-lLs-LsphhtptLpchs....l-.tt.AcpluhplAspluppaGGpslYhPpGhshchs.RDhcIas-Fs........GcNhtpLAR+YslohphIYpll+RhR+pchpcpQhc.L	..............................h.....................................p.h.u..p......hs....tplhphhG..Gp.......p.l.YlP...........+............s....p............p...........h............p............t............p............h.Rs..ppIhp.-.a.s............G..p.s.h...p..cLAc+YtLS.pplhpIlpc.ct..................................	0	57	101	114
+8599	PF08766	DEK_C		DEK C terminal domain	Mistry J	anon	pdb_1q1v	Domain	DEK is a chromatin associated protein that is linked with cancers and autoimmune disease.  This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [3].\	    The structure of this domain shows it to be homologous to the E2F/DP transcription factor family [1].  This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphastases such as Swiss:Q6NN85.	24.80	24.80	24.90	24.80	24.50	24.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.18	0.72	-4.19	59	900	2009-01-15 18:05:59	2006-05-09 13:39:52	6	46	294	1	579	859	1	53.50	28	6.68	CHANGED	o-pplpptlcclLpsu.DLpslTp.+plRcpLpp+h.sh-L.s..s+KshIcphlcphLs	........-ptlppplcpILpss..D...Lps.l...Tp.KplRppLEpc....h..sh...sL.s...p+KsaIcptltthl.......................	0	169	305	449
+8600	PF08767	CRM1_C		CRM1 C terminal	Mistry J	anon	pdb_1w9c	Domain	CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran.  This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat [1].	20.20	20.20	20.30	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.87	0.70	-5.52	29	475	2012-10-11 20:01:01	2006-05-09 14:14:28	6	15	300	13	326	464	6	280.10	33	28.82	CHANGED	QLupIYhDhLplY+hhSphISptlsttG.hsoK....pshl+shRolK+ElLKLl-Talp+up.....................................s.p..VhpshlsPLh-sVLhDYpp.NVPsAR-sEVLsshsollsKlps....hhpstlshIhcuVF-sTLsMIscDFp-aPEHRlpFapLLculstpCFsAllp..lssppFKhllDollWAhKHspRsVt-sGLslhh-llpNlpp............ssphuppFYpsaahslLp-lFhVlTDos..HKuGFphpshlLtplhpll-ss.....plssPlhs........hssNthalppalsshLpsuFsplstpQlpsFlpuLaphsp.s...................htpF+tplRDFLlplKEFuu	..................................................................................................................................QlshIahDMLsh...Y.+hhSp.Isttltt...t.............G..hs.s.+.............pshl+.th.RslK+EhL+Llpsalp+up..........................................................................................................s.p.....lhpphl...ssL.hcsVLhDYpp..s..lPsAR-sEVLs...hhssllpK.ltt....................hh.t.spl...s.I...h.csVF...csTLsM........I..s..cD.Fp-..aPEHR...spFapLLpulsppC....F..su.........llp.....ls......sspFKhll.DSl.hWAhKHspRsVsp..s...............GLphlhpLlpNhtp.................ptthuptFap...s.aahplLpclF.V.l.TDsp..Hp..uGhphpu..lL.tth.hpllp.s.....tlp.sl.s......................sNt.alp.palsphLpsuF.....splptt..........p....lp.Fl.pu..Lhp.tp..s...................................................hstF+tplRDFLlplKEas...............................................................................	0	131	195	269
+8601	PF08768	DUF1794		Domain of unknown function (DUF1794)	Mistry J, Pollington JE	anon	pdb_2fr2	Domain	This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.	25.00	25.00	25.20	25.40	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.06	0.71	-4.37	55	758	2009-01-15 18:05:59	2006-05-09 15:33:03	6	9	575	7	271	552	113	161.40	28	72.68	CHANGED	ssLsPLuhLlGsWcGc..GtuthPsh....p.sap...YtEclsFs.as....Gp.....shLtYp..t+................oath....ssGp....PhHsEsGahRh...psssp...................................l-hhlupPsGlsElhhGp......ssusplcLs.scu.....lspostu.+..pss...........................uhpRhaslh..ssssLsYshch.t.....shsp...s.Lpp+hsupLcRh	............................................tLhsLs.LlGsWcGc.....Gp.ushPs.............t.sapaspplsas.cs.........Gt.........sa..Lsap..sp.................................................oaph.............ssGp........Ph+pEs....GaaRh.....ssssp..............................................l-llhupssGhsElhhGp........hsss.p..l.cLt..ocu........lucostu.p......pss...........................shpRhasls.....pss.s.Ltas.ch..h.....ssss.....s.lpsahsApLcR...................................................	0	79	160	239
+8602	PF08769	Spo0A_C		Sporulation initiation factor Spo0A C terminal	Mistry J	anon	pdb_1fc3	Domain	The response regulator Spo0A is comprised of a phophoacceptor domain and a transcription activation domain.  This domain corresponds to the transcription activation domain and forms an alpha helical structure comprising of 6 alpha helices.  The structure contains a helix-turn-helix and binds DNA [1][2].	25.00	25.00	25.40	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.33	0.72	-4.17	28	674	2009-01-15 18:05:59	2006-05-09 15:37:23	6	2	490	7	111	516	13	102.40	58	44.53	CHANGED	clTsllHclGVPAHIKGYpYLR-AIhhslp-sclLsulTKpLYPpIA++YsTTsSRVERAIRHAIEVAWsRGph-slschFGYTl.........................stp+GKPT.....................NSEFIAhlADKLR	................lTsIIHEIGVPAHIKGYhYLR-AItM.VhpDh-.lLuulTKhLYPsIAKKYs.TTsSRVERAIRHA.IEVAWsRGs.l-sIsplFGYTl...........................s.sK.uKPT.....................NSEFIAhlADKLR............................	0	59	93	100
+8603	PF08770	SoxZ		Sulphur oxidation protein SoxZ	Mistry J	anon	pdb_1v8h	Domain	SoxZ forms an anti parallel beta structure and forms a complex with SoxY.  Sulphur oxidation occurs at the thiol of a conserved cysteine residue of the SoxY subunit [1].	20.00	20.00	20.10	22.10	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.87	0.72	-4.58	88	444	2012-10-03 16:25:20	2006-05-09 16:07:57	6	2	281	14	195	457	292	98.30	28	59.33	CHANGED	hRl+......ssttGslspl+sLlpHsMEoGhRKDt.sGphlPscaIpplsspaNGcsVhsuphusulSpNPahpFphpuspsG..plplsWtDscGsshssptsl	...................lp......ttttGphhcl.+hllpHPM-oGhp+Dt..s.sphI...........PspaIppls.s.p.h.s.....G....p........V.h.ssphssulScNPhhpFphpsstsG..plplsapDscGsshssph...........	0	44	121	159
+8604	PF08771	Rapamycin_bind		Rapamycin binding domain	Mistry J	anon	pdb_1aue	Domain	This domain forms an alpha helical structure and binds to rapamycin [1].	20.40	20.40	20.40	21.30	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.38	0.72	-3.92	38	401	2009-09-13 23:50:46	2006-05-09 16:26:34	6	35	280	10	270	412	16	98.30	52	4.38	CHANGED	ELIRlAlLWaEhWa-uLE-.ASRhaF....s-cNhctMhssLpPLH-hLc+.sP-TlpEsuFhpsaGccLpcApcalppYppopc.hssLspAWclYapVF++Is+Q	...........................ELIRVAlLWHEhWHEGLEE.ASRLYF....G-+NlcuMapsLcPLHphL-+....GPp....T..L+Es..........SFs.........QuaGRDLtEAp-asppY..................pp..............o........ts.......ls-LsQAWDlYYpVFR+Is+Q..................	0	111	162	236
+8605	PF08772	NOB1_Zn_bind		Nin one binding (NOB1) Zn-ribbon like	Mistry J	anon	pdb_2con	Domain	This domain corresponds to a zinc ribbon and is found on the RNA binding protein NOB1 (Nin one binding).	22.00	22.00	22.00	22.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.72	0.72	-4.15	37	331	2012-10-03 10:42:43	2006-05-09 16:52:55	6	6	292	1	235	333	15	73.50	42	16.00	CHANGED	pI+pl+palLRC+ACaphsp....-hs+pFCPpCGss.TLp+Vulols..psGphplalppp.hphssRGspYSlPpPpuG	..........I+pl+salLRCHuCFpsTp.........chsKhFCP+CGst.TLp.+Vulols......csGphphHlppN.h.h...ssRGp+YSlPpPpuG.....................................	0	84	130	194
+8606	PF08773	CathepsinC_exc		Cathepsin C exclusion domain	Mistry J	anon	pdb_1k3b	Domain	Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases.  This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini.  It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands [1]. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor [1].	20.20	20.20	20.80	20.50	19.10	19.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.78	0.71	-3.93	10	167	2009-01-15 18:05:59	2006-05-09 17:23:39	6	6	78	5	92	178	1	106.90	39	23.58	CHANGED	DTPANCTY-DLlGTWlFpVucts....cpslsCSphssscpolsVsLpcLslAsD-aGNpGaFTLIYNQGFElslNcYKWFuFFKYcppGopVhSYCccThPGWVHDlLGRNWACFsupKl	.........................................DTPAsCsa.-.lhGsWhhphu..t.................tp.ppl.sC..............s........t....s.....s....p..pph..h...lpLp..p.shAh......D.p........h...G.N..s..GpaTlIYNQG..FElsl.....Ns.....hK......aFAFFK.....Y...c..p...c..G....p...p......s.h..S..h.CpcThs..G..W.s........+..D..h......hs..ppa.uCahupK.................................................	0	42	50	67
+8607	PF08774	VRR_NUC		VRR-NUC domain	Iyer, L, Bateman A	anon	Iyer L	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.47	0.72	-3.98	77	1394	2012-10-11 20:44:44	2006-05-09 18:51:10	6	14	1169	0	380	1233	264	99.00	21	24.30	CHANGED	hpctphpstlhpthp.phs........hhhhhhthuh......................h..........uh.sGhPDlllh........hsssp........................hhhlElKuPs.......s+lpcpQhphh.ctltpp.....GhpstVspstp	..................................................................p..hhp.hp.phs...........h.hh.hu.........................................................h.th..............uttsGhPDhll..h..................hspsp...................................................................hhhlElKuss.................s+lpst.....Qhp....hh.chlppt.....GhtVtVsps...........................	0	109	224	308
+8608	PF08775	ParB		ParB family	Mistry J	anon	pdb_1zx4	Domain	ParB is a component of the par system which mediates accurate DNA partition during cell division.  It recognises A-box and B-box DNA motifs.  ParB forms an asymmetric dimer with 2 extended helix-turn-helix (HTH) motifs that bind to A-boxes.  The HTH motifs emanate from a beta sheet coiled coil DNA binding module [1]. Both DNA binding elements are free to rotate around a flexible linker, this enables them to bind to complex arrays of A- and B-box elements on adjacent DNA arms of the looped partition site [1].	25.00	25.00	28.10	27.70	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.64	0.71	-3.82	15	218	2009-01-15 18:05:59	2006-05-10 09:43:09	5	6	166	4	18	138	1	123.10	38	38.43	CHANGED	FPVts-LoauDYphLh+lpcphpppphslspllpslppclcslps..phs.--tKspIhchIppchptlpstss+cps.plssLtpF-sKcpFARK+s..KGRphoYEFuRlsp-lQccL...DpAIcplLcc	...FPVts-LohoDYphLhclsEchppcsh.ol-pllpslpp..clpsl.s..ths.--tKspILclIppps.phLts.ssKsp....ssstLhpFc-KcpFARK+s..KGRtlsYEFuRlSp-lQcEl...DcuIpclLc.......	0	1	4	14
+8609	PF08776	VASP_tetra		VASP tetramerisation domain	Mistry J	anon	pdb_1usd	Domain	Vasodilator-stimulated phosphoprotein (VASP) is an actin cytoskeletal regulatory protein.  This region corresponds to the tetramerisation domain which forms a right handed alpha helical coiled coil structure [1].	20.70	20.70	20.70	20.90	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.97	0.72	-4.64	6	249	2009-01-15 18:05:59	2006-05-10 11:43:15	6	5	71	2	102	217	0	39.40	58	7.98	CHANGED	-uhDhDRhKQEILEEVhRELpKVKEEII-A...hpQELp+huo	.......-uhDhDRhKQEIL-EhR+ELpKlKEEIIDA....IRQELu+.so.......	0	16	26	55
+8610	PF08777	RRM_3		RNA binding motif	Mistry J	anon	pdb_1owx	Domain	This domain is found in protein La which functions as an RNA chaperone during RNA polymerase III transcription, and can also stimulate translation initiation. It contains a five stranded beta sheet which forms an atypical RNA recognition motif [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.29	0.72	-4.18	15	306	2012-10-02 20:46:34	2006-05-10 12:05:32	6	12	140	1	190	739	8	99.90	29	22.53	CHANGED	GsllchoG.lscsso.R-clKshFppau...cVtaVDapcGsppGtlRFcssps..AccAhcpss-u....pl.l+ctplsh-lLpG-cEccYhpKIlpcpppph..sp.+pKGR	........................Gsllchp....sc...ss....Rccl+phhs.p.hu...........clt....a.l......D.a......h.....c.......G.s.p......c.......G......h......lR......Fcpsps..Apcsl.pphpp...s....................t........h.h.....c....s.....p.p......h.......phcl.Lp..G...-tEccah....pK....Iht.....c.pppph...sp.+p+t............................................	0	63	85	134
+8611	PF08778	HIF-1a_CTAD		HIF-1 alpha C terminal transactivation domain	Mistry J	anon	pdb_1l3e	Domain	Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1.  It plays a key role in cellular response to low oxygen tension. This region corresponds to the C terminal transactivation domain.	25.00	25.00	26.80	27.50	23.50	22.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.75	0.72	-4.49	15	244	2009-01-15 18:05:59	2006-05-10 13:04:30	5	11	100	5	63	202	0	38.70	68	4.98	CHANGED	hsshsLP...QLTRYDCEVNAPlpGpppLLQGEELLRALDQVs	......h-p.sLP...QLTpYDCEVNAPlQ..GspsLLQGcELLRALDQss...	0	5	14	28
+8612	PF08779	SARS_X4		SARS coronavirus X4 like	Mistry J	anon	pdb_1yo4	Domain	The structure of the coronavirus X4 protein (also known as 7a and U122) shows similarities to the immunoglobulin like fold and suggests a binding activity to integrin I domains [1].  In SARS-CoV- infected cells, the X4 protein is expressed and retained intra-cellularly within the Golgi network [2].  X4 has been implicated to function during the replication cycle of SARS-CoV [3].	20.40	20.40	20.60	124.50	19.30	15.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.09	0.72	-3.82	2	79	2009-09-11 12:31:16	2006-05-10 13:19:27	5	1	75	2	0	18	0	83.90	97	68.92	CHANGED	ELYHYQECVRGTTVLLKEPCPSGTYEGNSPFt.PhhsNtahl......hsFspssGoR+T.YQ.hscp.os+hF.h..phQ.chas	ELYHYQECVRGTTVLLKEPCPSGTYEGNSPFH.PLADNKFALTCTSTHFAFACADGTRHT.YQLRARSVSPKLFIRQEEVQQELYS........	1	0	0	0
+8613	PF08780	NTase_sub_bind		Nucleotidyltransferase substrate binding protein like	Mistry J	anon	pdb_1wwp	Domain	Nucleotidyltransferases (EC 2.7.7) comprise a large enzyme family with diverse roles in polynucleotide synthesis and modification. This domain is structurally related to kanamycin nucleotidyltransferase (KNTase) and forms a complex with HI0073, a sequence homolog of the nucleotide-binding domain of this nucleotidyltransferase superfamily [1].	25.70	25.70	25.80	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.64	0.71	-4.35	40	469	2012-10-01 22:14:54	2006-05-10 14:57:29	6	5	340	14	148	413	71	119.10	30	86.46	CHANGED	p+hssap+AltpLcculph...........p.hs-l.psGlIQpFEaTaELuWKhhKcaLch.pGh..plh.us...RsshRpAhptGLI...sDs-h.WhchlcsRNhTSHTYscchAcclhppIh.pYhsthppLhpplpp	..........................................................chpshppAlppLpcuhp....................p..schhhsGhIQ+FEaoaELuWKhhKchLph.pGh.....phh..us....+sslR.pAaptGLI...p-t..ch..WhphlcsR.NhTuHoY.sc..phA..p..plhppIh....pahs.hppLhpplp.........................	0	58	106	125
+8614	PF08781	DP		Transcription factor DP	Mistry J	anon	pdb_2aze	Domain	DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression.  The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [2] and negatively regulates the G1-S transition.	20.90	20.90	21.00	21.00	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.69	0.71	-4.51	24	312	2009-01-15 18:05:59	2006-05-10 16:38:45	5	6	136	1	166	279	7	135.20	48	35.77	CHANGED	p-sppLchE+pc.thcRIcpKps.LpELl.QplAhcsLlpRNpphEpp.sssPs..osIpLPFIllpTsp+ssl-spISsDppchhFsFsso.FE.IHDDhpVLKpMuhshulcsstssspshphspohss....................hslpshlsthspspttp	....................................QEspsLEhE+p+.RhERI+pKpupLQELl.....lQplAFKNL.VQRN+psEpp..sptPss......sosIpLPFIllNTu++TlI-C.SISsDKhEYlFsFDs....T.FE.IHDDlEVLK+................MGhuhGL...-sGpCo.c.slphu+ohlP.....................psLp.Ylpth.t.....s...........................................................	0	54	85	121
+8615	PF08782	c-SKI_SMAD_bind		c-SKI Smad4 binding domain	Mistry J	anon	pdb_1mr1	Domain	c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]	25.00	25.00	25.80	30.30	24.60	18.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.42	0.72	-3.87	7	320	2009-01-15 18:05:59	2006-05-10 16:54:37	5	4	90	2	180	285	0	92.80	47	15.16	CHANGED	SF+VYHECFG+C+GLFlPELYsuPsAuCIQCh-CRhMFsPpKFVsHSH+s.E.pRTCHWGF-SuNWRuYlhLspcYts+-cpupLpplL--lKtKFc	............uFcVhHEChhtC+GhFl.PphYsu.scAtCIpCh...Cshh.FoPpKFlhHSHR..s..s.....-..+......h.T...p..uhs.ssWRpaL..cLs........s.c.st..ppc.Ltphh--lKthFs.............................	0	38	54	115
+8616	PF08783	DWNN		DWNN domain	Mistry J	anon	pdb_2c7h	Domain	DWNN is a ubiquitin like domain found at the N terminus of the RBBP6 family of splicing-associated proteins [1].  The DWNN domain is independently expressed in higher vertebrates so it may function as a novel ubiquitin-like modifier of other proteins [1].	21.70	21.70	22.30	21.70	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.41	0.72	-4.04	26	408	2012-10-03 10:59:06	2006-05-10 17:03:34	6	14	265	1	270	417	1	72.60	46	11.02	CHANGED	laYKF+.Sp+c.hsplsFDGo.sIoVhDLK+cIlppp+LGcupD......F-LplhNspTpE.....E.Yp.DDstlIP+sooVll+RlP	....VaYKFp.Sph.s..asslsFDGh.tISVt-LK+pIhppc+Ls.cupD..........hDLpIpNupT.pE...........E.Ys.DDsslIP+soSVIlRRlP......................	1	80	164	220
+8617	PF08784	RPA_C		Replication protein A C terminal	Mistry J	anon	pdb_1z1d	Domain	This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A).  RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.39	0.72	-3.60	23	349	2012-10-04 14:01:12	2006-05-11 10:35:05	6	5	269	16	223	404	8	100.20	20	37.20	CHANGED	Hhhho+spstssuu...........sssssssuhsss.........ushsussspshs......u.hsshpppVLshl+p..tstsscGlphc-ls.ppL..phssscl+pAl-hLss-GpIYSTlD-p	........................................................................................tt.................s....s...st..ss.hs..ss...........ssh.s.sss.t..shs..........s.hsshp.ppVhshl+s......stsp-....G...lphpplt..ppl.......ph..........s.hs...plppul-hLhspG.hIYoTlD-p.......	0	67	119	185
+8618	PF08785	Ku_PK_bind		Ku C terminal domain like	Mistry J	anon	pdb_1q2z	Domain	The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired.  Ku is a component of a multi-protein complex that is involved in the NHEJ.  Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).  This domain is found at the C terminal of Ku which binds to DNA-PKcs [1].	21.30	21.30	21.40	21.40	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.34	0.71	-10.58	0.71	-4.21	9	263	2009-01-15 18:05:59	2006-05-11 11:19:19	6	10	204	3	172	270	0	117.30	26	17.18	CHANGED	GolNPspDFpsLlpp+sts..hpcAhsQhpp+IhpLlpss.psp.apKulpClhAhRctslh.upscpFNsFLppLpphhps+pLpcFWp.llsp........cploLIopsEupsSsVosEEAppFLs...ppE	................................sPht-Fc.t.hl.........p.........p.........p.......css.........hpc..............AspQhtshIpphlpss....tss...at+..u..h-sltshRcpslphp.E.........sphaNsFl.ppL+c....pl...........p....c....p.....h........p........cFW.p.hl.hp........p.plsL.Isp..pEsp....s......Sp.V...otc-A.p.p.Fh....t...........................	0	62	96	135
+8619	PF08786	DUF1795		Domain of unknown function (DUF1795)	Mistry J	anon	pdb_1tu1	Domain	This is a bacterial domain of unknown function.  It forms an antiparallel beta sheet structure and contains some alpha helical regions.	20.90	20.90	21.00	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.42	0.71	-4.30	39	1088	2009-01-15 18:05:59	2006-05-11 11:40:40	6	4	617	4	112	378	4	129.40	29	78.06	CHANGED	EGshsLPss.apDcolNlhhhsssts..shollloRssltsucslpsalpcplptl.pppLptaphhs......ppssplusp....suhplp.........hpap.ppsp.laQhQshhhhs.........pplLhhThTs..ssshssppcttatsllsSh	...........................................hshsL.P..us..hpD.......p.......S...............Nh...hVhoDstsp..psslVIst-.hs.s......-.sLsshsp+hh.sp..cs+.sphplhs......scslpLtsp.......h.pLD.............shhs...upsp.psa..p....shllh.ls.........splLshphTh..sss.ppptpsp.hpslIpoh...........................	0	8	30	70
+8620	PF08787	Alginate_lyase2		Alginate lyase	Mistry J	anon	pdb_1uai	Domain	Alginate lyases are enzymes that degrade the linear polysaccharide alignate.\	\	They cleave the glycosidic linkage of alignate through a beta-elimination reaction.  This family forms an all beta fold and is different to all alpha fold of Pfam:PF05426.	25.50	25.50	25.60	28.80	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.01	0.70	-4.71	70	350	2009-01-15 18:05:59	2006-05-11 13:04:19	6	15	175	10	153	347	22	224.10	25	77.76	CHANGED	hDL...opWplslPh............ts....psspltspplts...saps..........haahssspus..hsFhsssp.....u....oossophsRoELREhh................s.sttsWshssss............phpAolpVspVsss............VlluQIHutp..............spPlh+lhap......ppG...........slhhthc................stttshthshhs...................sltLG.........ctFsaplp...lsss.....plplshsup....sptsh.....................................tsasspt..hYFKAGsYsQ...ssstsst.......................shupspFhpLpl.s+	......................................................hslspWplplPh................ts.stplpsspl.s......saps..........haahssstss..lhFhs..sss.....us...sTtsupasRoELREth................s.p.tsWhhssss..p...............phpuslpVsplsss.t..........llluQIHutp.............sspPlh+l.at......psG...................slhhthc.................ssststthslhs....................sl.Ls.........cpF.saplp...lssu.....pl.sVphssp.....sttph.....................................tsassp...hYFKAGsYsQ...ssss.st.......................phucspahpLplt..............................	0	22	98	137
+8621	PF08788	NHR2		NHR2 domain like	Mistry J	anon	pdb_1wq6	Domain	The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerisation and protein-protein interactions.  It forms an alpha-helical tetramer [1].	20.10	20.10	20.10	23.90	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.45	0.72	-4.49	5	245	2009-01-15 18:05:59	2006-05-11 13:49:28	6	7	68	2	108	216	0	64.00	71	11.19	CHANGED	pEEslDHRLT-REWA-EW+H..LDphLNCIMDMVEKTRRSloVL.RRCQEuDREELNYWtRRaSDuEEs+	...............QEEhlDHRLT-REWAEEWKH..LDpl.......LNCIMDMVEKTRRSLTVL..RRCQEADREELNaWhRRYS-sE-h+...............	1	13	21	55
+8622	PF08789	PBCV_basic_adap		PBCV-specific basic adaptor domain	Iyer L	anon	Iyer L	Domain	The small PBCV-specific basic adaptor domain is found fused to S/T protein kinases and the 2-Cysteine domain [1].	20.40	20.40	20.50	20.50	20.30	19.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.93	0.72	-4.29	24	80	2009-01-15 18:05:59	2006-05-11 14:12:19	5	8	13	0	5	80	1	37.90	44	19.68	CHANGED	TG+lsuKGRtlacss+GtpYVhssu.KKVhVpchhpPpts	....TGKlsAKtRcVF+ssKG+sa.Vhps.s....KKVYVKKlhsPKt.....	0	0	2	4
+8623	PF08790	zf-LYAR		LYAR-type C2HC zinc finger 	Mistry J	anon	pdb_1wjv	Domain	This C2HC zinc finger is found in LYAR proteins such as Swiss:Q08288 which are involved in cell growth regulation.	20.70	20.70	20.70	22.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.22	0.72	-7.50	0.72	-4.24	30	311	2009-01-15 18:05:59	2006-05-11 14:27:46	6	11	250	1	203	291	3	27.80	55	8.36	CHANGED	aoCIDCspsF.stpsa+sHouCITEsEKY	..hoCIDCspsF..GssY+sHopCIoEspKY....	1	70	114	167
+8625	PF08792	A2L_zn_ribbon		A2L zinc ribbon domain	Iyer L	anon	Iyer L	Domain	This zinc ribbon domain is found associated with some viral A2L transcription factors [1].	22.90	22.90	22.90	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.84	0.72	-4.40	14	90	2012-10-03 10:42:43	2006-05-11 14:40:21	5	3	78	0	7	72	3	32.30	41	12.11	CHANGED	pp.phCph..Cspstlh...pppshhhCh.Csssh.h	......sl+hCss..Cppss..ll...o-puYchClhCpslaph...	0	2	7	7
+8626	PF08793	2C_adapt		2-cysteine adaptor domain	Iyer L	anon	Iyer L	Domain	The virus-specific 2-cysteine adaptor domain is found fused to OTU/A20-like peptidases and S/T protein kinases.  The domain associations of these proteins indicate that they might function as viral adaptors connecting the kinases and OTU/A20 peptidases to specific targets [1].	20.10	20.10	20.10	20.10	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.65	0.72	-4.07	38	112	2009-01-15 18:05:59	2006-05-11 14:53:58	5	10	28	0	2	116	7	36.90	36	19.63	CHANGED	ppCpcF....pcsPs.hNPhTG+sI+hsGPsY+clhccCsss	.......hCpcF....pcsPs.hNPhTGRsI+tsGPsactLtccCss....	1	2	2	2
+8627	PF08794	Lipoprot_C		Lipoprotein GNA1870 C terminal like	Mistry J	anon	pdb_1ys5	Domain	GNA1870 is a surface exposed lipoprotein in Neisseria meningitidis that and is a potent antigen of Meningococcus.  The structure of the C terminal domain consists of an anti-parallel beta barrel overlaid by a short alpha helical region [1].	25.80	25.80	26.50	26.30	24.80	25.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.00	0.71	-4.36	2	580	2009-01-15 18:05:59	2006-05-11 14:54:44	5	2	98	13	6	555	0	148.80	63	58.36	CHANGED	QsHSAlsALphEplpss-+.sphlspRpFhluDluGEHTuFspLP-.G+ApY+GpAFuSDDAsGKLTYTIDFAAKQGHGKIEHLKoPE.NV-LAuu-lKsDcKpHAVI.GsshYsttEKGoYpLulFGspAQElAGSApVchuptl+cIGlAsKQ	......................................QsHSAlsALQhEp.lpss-+ssp.h..lspRp.Ftlu-IuGEHTuFspLPcsG+AsY+GpAF.....u..S.........D....D.........A.........G......G.......KLTYTIDFAAKQGaGKI...EHL.K.o...PEh.N...V...-LAu...A-............l.........Ks............D......EK....p..HAV.......I...SGs..s..hY.s....p.......s..E....KGoYpLulFGs+AQElAGSApVK..hsptl+cIGlAuKQ................................	0	1	2	4
+8628	PF08795	DUF1796		Putative papain-like cysteine peptidase (DUF1796)	Iyer L	anon	Iyer L	Domain	\N	21.60	21.60	24.50	24.30	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.09	0.71	-4.62	26	236	2009-01-15 18:05:59	2006-05-11 14:56:26	5	2	163	0	42	187	9	161.00	29	64.13	CHANGED	hsthlSLGutCtsAhhLpKhsLR..shuhPFDahhs.olssltchlpscFsshhp.pth........................................t............h..pshhtallacshauh.sha-apss..s..s......chhtchp+Rhcphhpplpssp..........plhFlR.....ssh.shctlh-hhphltptsss.pshhlll.htppsts	...................pslhSLGppChsAhtLpph.pLc......shuushDahh....Sso...Lpp...Vs...pLLpNc.FscFhphpsl...............................................................p...............thh.psssphhl..cDshYsl.ohHDFtsshss.psh..........tY.ch+tphc+RlsRFlpplpssc..........slLFlR.....tss.s.h-EshpLpplLsphspp.phplLll........ss.......................................................	0	9	24	32
+8629	PF08796	DUF1797		Protein of unknown function (DUF1797)	Mistry J	anon	pdb_2ffg	Family	This is a domain of unknown function.  It forms a central anti-parallel beta sheet with flanking alpha helical regions.	21.40	21.40	22.80	39.90	21.10	18.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.19	0.72	-4.10	17	675	2009-01-15 18:05:59	2006-05-11 15:37:50	5	1	670	2	59	161	0	68.10	54	86.93	CHANGED	IIsRLcuMtcst..suEsppRpFE+pG..hspVsasppsc...sapLcchpsccp...apFDsIDLlAIEIaDLL	..................IIsRLEAMtp....DGtshpRpFER-GVslspVuasccpE...hFpLc-scs+Eo...YpFDsIDLlAMEIY-LL.	0	11	31	45
+8630	PF08797	HIRAN		HIRAN domain	Iyer L	anon	Iyer L	Domain	The HIRAN domain (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. The HIRAN domain is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes [1]. It has been predicted that this domain functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks [1]	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.27	0.72	-4.12	51	781	2009-09-10 22:04:53	2006-05-11 16:15:26	6	29	554	5	366	662	33	100.50	19	15.98	CHANGED	hGshpsps.......huhph......................hhphlph....uptlhlpRpsps.............................................hDpsA....................lpVtsss......ut............plGalPcchuphlus.Ll-pt...hhphcuhlh.........ssp....tthsh.pplhlhhpsh	.......................................................................hth.......huhph...........................h.t.lp........uph..l.tlpREs.sNs............................................aDps.A.............................l+..V....sss.......st.............plGalscphAthlus.hhDpt....hhphpu.h.l......................................t....................................................	0	103	231	304
+8631	PF08798	CRISPR_assoc		CRISPR associated protein	Mistry J	anon	pdb_1wj9	Domain	This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	25.00	25.00	27.40	25.90	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.19	0.70	-4.58	50	667	2012-10-01 21:23:39	2006-05-11 16:20:22	6	2	628	14	132	457	17	206.90	36	97.62	CHANGED	MYLS+lhLssppttstp...........hsssYshHphlhphFss.......t.ssptphLaRlE...........pttstsplLl.SsppPchst................sshshpscshhspLpsGpphpF+LpANPstpt.........................t.ttpup...chshhppp.pthpWLp..++upptGFplhs.............................hhphpshppcphpppp...........p.lphssVsF-GhLpVsDssthhpsLppGIG+uKAaGCGLLolss	......................................................................................................MYLSRlpLcs.sp...h....pstph............ps.YshHphLasLFPs............................spc+pFLaRhE..............phpsshphhllSpppPsto.......................shhslps+sF.hsp.LpsGppLpFpLRANPshsp.............................................................h..ptp.t.phc....sp.s.cup......cl.h...hhppp..stlsWLt...ppu-ps..G.F.sLhc.................................................ssVcu.hcpp..p.hc+cp..........ppphlphuoVcasGhLs.VsDP..s...hFhppLspGhG+u+AFGCGLhhltP.....................................	0	39	99	117
+8632	PF08799	PRP4		pre-mRNA processing factor 4 (PRP4) like	Mistry J	anon	pdb_1mzw	Domain	This small domain is found on PRP4 ribonuleoproteins.  PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.	25.00	25.00	25.10	25.20	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.24	0.72	-4.67	61	535	2009-01-15 18:05:59	2006-05-11 16:32:06	6	15	264	2	398	508	1	29.90	51	6.74	CHANGED	Vhp+LRplsEPIsLFGEsct-RpcRL+plh	...Vhp+LRplGEPIsLFGEsst-RhcRLRpl......	0	135	213	321
+8633	PF08800	VirE_N		VirE N-terminal domain	Bateman A	anon	PSI2 target AAO76744.1	Domain	This presumed domain is found at the N-terminus of VirE proteins.	20.60	20.60	21.30	21.50	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.43	0.71	-4.41	14	419	2012-10-02 15:26:12	2006-05-11 17:59:31	5	13	90	0	49	404	58	131.70	27	24.52	CHANGED	-tpphtcp.LPtlhsuutacc..tcstpphptasGllhl-lc+Ls..pchstl+pphtthP.T..hhAFhusSG+uVKIhlhhst.-ss.h.t........p.tp...ap....utAYphssphYpthl...shsl-hps.slsphChhoaDP-sYa	.............................tphKpp.LPhlsPuupFpc...cstpphtpasGllhlDlDcLs..sh.....p...E.h...tpl+p..ph..hp..tP...ts......hhsFhosSGcGVKlhl.....hh.s.h....s....sss..h............t........ap....tpuY.ph.ss..p..h..ap.hh......sh...plDh.p...s...t..slsRhCh.loaDPcsaa......................................	0	20	45	49
+8634	PF08801	Nucleoporin_N	Nup133_N;	Nup133 N terminal like	Mistry J	anon	pdb_1xks	Domain	Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure [1]. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.	23.70	23.70	23.70	23.80	23.60	23.50	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.45	0.70	-5.73	57	599	2012-10-05 17:30:43	2006-05-12 09:01:07	6	12	283	1	388	605	4	407.80	16	33.61	CHANGED	sp.stapshphhs.hPstlhpphsps...........................p..spsuhhschshuhhsscsclhlWs.Y..................................t.ssph.h........................h.st.ppslsul..........sl.VpPps..G..hahpslsahhslusshp......lhlhh.........................lhssphssphhsspsss.hlhssssGRlhhhuhps..sh.pl..ph.pt.ps.......psst.shstsuh.usl....hss..........................................tt.cs.lsplpssppc.....phlashoscuhlphaplp.....sspthpp.......lhphhtpth.pth.......................................s.....phcllclpslstp.....................psthhhLluhspsusph.hthh.h......................................h...h...........................................p..hh.ss......h.t.phps......thhs.tlalsssspps...................................hlhssssshs..................hhp...pt...........hEsshhhp.s..................................hss..uhpp..............p.p.....ps.p.hhlhpstGlhh	.......................................................................................................h...ph.s.lPstlhc..thsth...........................pstphhul.h.sphshAWlshcsclhlWsY...........................................p.stph.h.............................h..ss.spsl.uV...............sl.ltsps..G..hahss.lp...ahhs.lssshp.......h.l.s.....................................................................lhssthh.....s..h.hsss..sts..h..lhuossG.Rlhh.........hs.h.s.s.........slapl.......th..pttps.......................phpthshst.uu.l.u.l......hss......................................................................st.cs..lspl...th-..ps+........phlaslospu.hlp..haclp.....sspthtt.......lhp.h.pst.hhtth.................................................s.t.p.phpllsl...p..slsss......................ts...h.htLlu....h...s.ps.uh.phahshssh.........................................................t.h.h..h..............................................th.s..s..............s....p.pt.......hhs..t.hhl.hh.s.pps....................................hhhhsssshs.....................t........................-.shhhht........................................................................................................s.t.hhhhps.Gh.......................................................................................................................................................................................................................................................................................	0	119	200	315
+8635	PF08802	CytB6-F_Fe-S		Cytochrome B6-F complex Fe-S subunit 	Mistry J	anon	pdb_1q90	Domain	The cytochrome B6-F complex mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  This domain corresponds to the alpha helical transmembrane domain of the cytochrome B6-F complex iron-sulphur subunit.	23.30	23.30	23.50	23.80	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.69	0.72	-3.95	19	215	2009-01-15 18:05:59	2006-05-12 09:15:23	5	3	170	9	83	203	111	37.50	46	19.78	CHANGED	D.VPDMu+RplhNLLhhGulussssuhLhPhspaFlPPu	.....VPDMuRRQhMNL.LhhGslohsAsGhLhPhspaFlPPt....	0	20	54	73
+8636	PF08803	ydhR		Putative mono-oxygenase ydhR	Mistry J	anon	pdb_2asy	Family	ydhR is a homodimeric protein that comprises of a central four-stranded beta sheet and four surrounding alpha helices [1].  It shows structural homology to the ActVA-Orf6 and YgiN proteins which indicates it could be a mono-oxygenase.	27.10	27.10	27.20	28.40	26.60	27.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.19	0.72	-3.91	23	612	2009-01-15 18:05:59	2006-05-12 10:05:35	6	2	606	6	47	201	70	96.50	66	94.04	CHANGED	LLQlDFsasGP.FG--hupuhpsLAcSIspEPGhIWKIWTENppspcAGGIYLF-scsuApsYLpMH.oARLpsh.Glsclpu+lFDlNpsLopIs+uPl	...............LLQlHFsFsGP.FG.-tMscQLp..sLAESINpEPGFlWKl......WTESEKN+EAGGIYLFp-EcoA..A.YLEKH..TARL.KsL.GV-EVsuKlF-VNEsLopINpupL...................	0	11	28	37
+8637	PF08804	gp32		gp32 DNA binding protein like	Mistry J	anon	pdb_1gpc	Domain	gp32 is a single stranded (ss) DNA binding protein in bacteriophage T4 that is essential for DNA replication, recombination and repair. The ssDNA binding cleft of gp32 comprises regions from three structural subdomains [1].	20.10	20.10	20.90	22.50	19.60	19.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.26	0.72	-3.87	10	98	2009-01-15 18:05:59	2006-05-12 11:05:39	5	1	90	4	0	87	390	82.80	51	31.51	CHANGED	DccEWKLchDsuGNGpAVIRFLPuKs-Es.LPFVKLlNHuFKcNGp.WYIENCsSTHGDaDsCPVCpahpps-L.a.....Noss-ctphhup.hKRKtSYW	............Dcp.WKLchDsu.GN.GpAVIRFL..P.......u...........s....t-p........hPasplhsHuF+ts....Gt.WYIENs..oThGc..ssPVspa..ppcL.a.....Nsspc..p...p........KRKhuaa..........................	1	0	0	0
+8638	PF08805	PilS		PilS N terminal	Mistry J	anon	pdb_1q5f	Domain	Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells.  In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator [1].  Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus [2].	20.80	20.80	20.80	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.73	0.71	-4.64	18	332	2012-10-03 10:38:27	2006-05-12 11:51:41	6	3	257	5	49	317	16	137.50	30	72.62	CHANGED	sscsssEpsNlsslhsss+u.hKus.uuYs...uushsssLlphtulPssMss..sGs......slhNsWGGsVTVsss.....usst.oFolThssVPpssClsLsTplusu...hsshsIsus......shssu..plssssAs....osCsus.....sNTlsaTos	........................................................................tpstpEtsNlpsIhsss+u.hh.pus.suYs.......suphsssLlp.hsshP..ss.Mhs....sus..........slhNuW.GG.s.VT.luss.........usss..uFTlT...h...s...sVPpcsClpluT.t.huss.....htsh...s...lsus..................sh.su.........lssssAu......ssCsss.....sNolsaT............................................	0	13	27	37
+8639	PF08806	Sep15_SelM		Sep15/SelM redox domain	Mistry J	anon	pdb_2a4h	Domain	Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif [1].  This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum [1].	21.20	21.20	21.40	21.70	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.43	0.72	-4.23	12	179	2009-01-15 18:05:59	2006-05-12 13:10:50	6	2	121	2	112	204	1	73.00	33	48.92	CHANGED	putl.pssGU+LsphPcVctFlpsDh...sha.sLphKalhGucP.lhLhDcpsp.hEc.lslschspDclpphltp+shh	.............................s.ttl.ps..sh..p....p..h.sthPp...l.puFlpp-h...tha...slplKalhGuc.PhLhLLD.c.pGp..tEp...lsl.pcW.sp-plppalpp+hh...............	0	44	62	91
+8640	PF08807	DUF1798		Bacterial domain of unknown function (DUF1798)	Mistry J	anon	pdb_2ets	Domain	This domain is found in many hypothetical proteins.  The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.	25.00	25.00	40.00	65.50	21.00	19.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.43	0.72	-4.35	19	391	2009-01-15 18:05:59	2006-05-12 13:39:28	5	1	391	5	32	144	0	109.40	44	93.99	CHANGED	hTppLlptscchhp+Y.ps..+cpspcaDFappVKPas-chcphlcpWpphAhpalppt+PcYl+tpQl-tsh-Nhpplslpuaas+spcKRFh-hhcSlpYsLphlh-tlt.p	.......s.sEpLl.cssphpppapps..Kpptp-aDFYpsVKPas-clDshLschK.ht.hhIch....Yhsspph-hlhsNlppluVpCaap+os+KhFlE+hcSlpYsLQNIl-tlt.Kc...	0	8	18	26
+8641	PF08808	RES		RES domain	Bateman A	anon	PSI2 target CAE41587.1	Domain	This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	20.50	20.50	20.80	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.51	0.71	-4.16	184	1322	2009-01-15 18:05:59	2006-05-12 14:02:02	6	8	874	0	452	1175	109	164.20	15	70.86	CHANGED	plaRlptt.............................ph.t..s.............s......s.Rass...........s.uhssl.Ysuts.....hssAlhEs.......................................hhhsthhhtththsshthttth....t........t.h....htshsshts.t............thspthsp...thtt.sh........................ulhhsS...sh................s.....s..stslslhsst............................tthphhpspththths	.................................................................................h...................................ph....s.........t.hh..hG..u.Rass..............t..shs.sl..Ysups.....hpsAlhEs.........................................................h.h..................................sthh...sthh...ht.th.t.hssh.h...thtph.......hph...............h..........h......th..ts.sh.tt..........................h.hspt...hup.......thp..sh..............................t.......GlhhsS......sh..............s......s.....shslslas.t.......................................................................................	1	115	273	368
+8642	PF08809	DUF1799		Phage related hypothetical protein (DUF1799)	Bateman A	anon	PSI2 target CAE43631.1	Domain	Members of this family are about 100 amino acids in length and are uncharacterised.	20.80	20.80	21.10	20.80	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.01	0.72	-4.18	15	119	2009-01-15 18:05:59	2006-05-12 14:06:48	6	3	110	0	32	116	31	77.20	31	69.89	CHANGED	LtthG..hp.-Da..c..psshEVWPEN.htAhplFtuhuTQWRs........GssGshGLDYusl.shhchhGlctEppp-lassl+lhEppALchl	...................h...................hplWP-s.h.uhplFhshuTQWRs..................Ghu.G.s.sGLDYusl.tlhchh.sl.p.scpp.tlhsclRlMEttALphh......................	0	2	17	26
+8643	PF08810	KapB		Kinase associated protein B	Mistry J	anon	pdb_1y71	Domain	This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	20.00	20.00	20.00	41.60	19.80	18.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.34	0.71	-4.03	10	347	2009-01-15 18:05:59	2006-05-12 14:14:48	5	1	347	2	28	126	0	112.60	61	88.34	CHANGED	YKTGsYhGpIpE-+spp..hLVcVcAVlKHPpQGDLHNPsQs.-ssFFHERKALuahEKphls+utV+sa-s.ElPsYs-SLppAlschcs+Lps-soc...aAppSLcsLcpL+c-Ytl	.HKTGsYuVsIsE-sss.s..lLVKVcQVIKHPKQGDLHNPsET.-sVFFHERKALSaaEKRaspcSpL+cFNs.-.lhcYEDSLQpAlocLEspL+tpp.oc...aAchSLsoLscLKcDYsL..	2	9	17	24
+8644	PF08811	DUF1800		Protein of unknown function (DUF1800)	Bateman A	anon	PSI2 target AAK23953.1	Family	This is a family of large bacterial proteins of unknown function.	25.00	25.00	26.60	26.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.46	0.70	-5.56	77	530	2009-01-15 18:05:59	2006-05-12 14:19:30	6	11	396	0	221	585	994	467.30	24	84.11	CHANGED	tphLsRhsaGsp...suplsphhp.h.......uhpsalppQl...............stsss..sshhtt.hsphs....................................................................................................................................................ttptttcpt..t........................................hh.t..tuhhtpAlhus.spLpERhshFWpNHFsVSspc...s.h.phhssshpp-slRsauhG.......pFc-LLtAlsppPAMhhYLDshps......................................s.t.......ctt...t.NENaARElhELaTLGl........................s..uG.....YoQpDVpphARshTGWslsstt..........................tsshahapsph........H-susKs...............lL..Gpshs.s..............sG.tcs..ptsL-hLspHPsT..ApFlup+Lhp+FVu.....Ds.PssuhVpRlApsFp...po..............cGDltAVlpslltssEhhss..........tsK.....l+sPhchhlushRshshp.sss..................................................tthhshlspLGQshatsso..........PsG......as.sssuWsuspthltRhphstpl..usthhsshh.............................sspshtt............hh.thhss...shospop.psltps.sttt................................hlslllsSPEF.hc	.....................................................................................................................................................................................................................hhLpRhsaGsp...ss..plsth...ht..h........shpthltt...l......................ts..t.....sshh.....tt...httht.......................................................................................................................................................................................t.ptthpp..........t....................................................................................................htphtt...th....lt..phlh..s..s.......s......tLpERh.shFWpsH.Fslutpp...s.h.ph.......hhh.hppphlRtpA.hG..................sFp-LLtAlspcPAMLhYLDstps..........................................................................................ppttsNENaARElMELaTLGl.......................ssG........YoppDVpphARshTGWshss......................................tstahapsp.h........H-sGsKs........................................lL.Gp..s.h.t................tG.tcsctsLchLhp..+..P....s..T..ApFlup+LhpcFVu.............-s....P...........s.........su.hV..p+lAssFp...ps....................sGDltsllpsllpsschhss....h...............ss+lKsPhchllushRshshs.sss...................................................t.h.hs...h.h.ppLGQ.shatsss.......................................PsG......a......s.........s.....s...suWlsssshltRhphsttl...sst.hhtt.h....................................................................................s.tth..t...............................................th.lts....t....hssps.t.tsltpt..st.p..........................................................................hhthlhhuP-a.h.....................................................................................................................................................	0	79	146	186
+8645	PF08812	YtxC		YtxC-like family	Bateman A	anon	PSI2 target YtxC B.subtilis	Family	This family includes proteins similar to B. subtilis YtxC an uncharacterised protein.	20.80	20.80	20.80	21.40	18.90	20.70	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.41	0.70	-4.84	33	299	2009-09-10 22:38:25	2006-05-12 14:27:35	6	1	295	0	79	225	0	214.20	31	73.96	CHANGED	hc.hhlusllschllpph-cchltclIpcsYhahcp-EpppIhch.uppILcs-ppth..pph.phs++s.Ihcclt-hlp-s.splsl-GFlsFRL+-YhccLcchl-pAl-EYhhE+EYpEFIcLL+aFV-hQcs+lctVallhs.stpahLaDcctcplss-hlpphhsc..lhppslsh-DlLISsLIolAPccIhlast-psc...phlpTIpsVFp-RVph	..............................................................pthlhsslsphIlp.hhppchlhpllpcpaa.ahc.p-EpppIhph..upplLcscppt...h......t....p.h.phs.............pc.shIhsplpsalp-s.....phshsuFlpFRL+sYhcplpcls-hAlDEYhhEpE...YppFIch....L+.aVc..pcs+lspV+llhc.p.sFhlaDccscclppc.pltphhcc..htppsl.h-..shlIusLloluPc+Ihlasc.cps.p.....phlpTlcsVFp-RVp.h....................................................	1	38	64	69
+8646	PF08813	Phage_tail_3		Phage tail protein	Bateman A	anon	PSI2 target CAE43633.1	Family	This family of proteins include phage tail proteins.  They probably include bacterial Ig-like domains related to Pfam:PF02368. Which also includes a number of phage tail invasin proteins.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.90	0.71	-4.85	12	222	2009-01-15 18:05:59	2006-05-12 14:32:47	6	3	207	0	34	177	8	149.50	24	74.81	CHANGED	SuWspLss+ss+ssssossshsl-GIDTocst.assG.Ghuphh.lsoWs-lspVpslupsGG-QQFhsaphLpD.D.+cpQIPThKSAhshThThAa-.shsaatsLcpAD-s+pshslRhplPsusph.hasuYhuFscsPohshNthhsholslSltuc.ThhAu	.........................................................................................h..h..s..sapcl.sp.lp..-lspsGu-tphlphshLpD...s..hp..p..phss...hps.Asshshsh..uac.s..s..p..s..s..ap.sLct.ss-scp.hhshchth.Ps.G..s....ps...hapuhlSh.c.....hs..ssssNtlhsholslslpu.c..shh..s.......................................................	0	3	13	27
+8647	PF08814	XisH		XisH protein	Bateman A	anon	PSI2 target ZP_00111899.1	Domain	The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required [1].	25.00	25.00	26.10	26.00	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.64	0.71	-4.16	8	139	2012-10-11 20:44:44	2006-05-12 14:41:39	5	2	37	2	44	187	1	116.50	41	95.22	CHANGED	MsAKDlaH-sVKsALhKDGWtITcDPLhl+hGc.sslaIDLuA-KlIAAE+pspKIAVElKSFlu.sSpIsDF+sALGQaIsYRhlLcsp-sERlLYLAlscssYcsFFppchsQhllpcpplpLllaDsEpEpIlQ	.................MsA+DlaHpsV+pAL.K-GWhITcDPhhlp.hst.hphhlDLuAE.......+..........llAAE+ptpKIAVElKSFlu..S.lp-hcpAl..GQal.Y+hhLpt.p..-P-RhLYLAlspshYpsaFpp.hhphhlpc.plpLllassppE.Ih.....................	0	11	31	44
+8648	PF08815	Nuc_rec_co-act		Nuclear receptor coactivator	Mistry J	anon	pdb_2c52	Domain	This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.	19.80	19.80	19.90	19.80	19.60	17.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.48	0.72	-4.43	10	226	2009-01-15 18:05:59	2006-05-12 15:38:57	5	16	42	2	81	169	0	49.10	64	3.62	CHANGED	EGpsDE+ALL-QLsohLsstD..uLEEIDRALGIPcLVsQutsh-...-pF	...EGpsDE+ALLDQLhohLsspD....GLEEIDRALGI.P-LVs.Q..uQul-s..-tF......	0	4	9	30
+8649	PF08816	Ivy		Inhibitor of vertebrate lysozyme (Ivy)	Mistry J	anon	pdb_1gpq	Family	This bacterial family is a strong inhibitor of vertebrate lysozyme.	19.90	19.90	21.00	21.00	19.10	19.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.63	0.71	-4.12	17	506	2009-01-15 18:05:59	2006-05-12 15:59:04	6	2	482	7	45	183	8	116.00	56	74.15	CHANGED	Lsppssa+ssWppMlpupppLPpWlppstGous.PhpslshsGppYlVGshCKPHD.CuupphhVhautDccp...AaGlhVplspt..sshcsPocaAsapWLGpPscs........hpuhLpppLc.pcPN	.............................LAKucsTKAAFNQMVQGHK..LP..A....W.VMK.G.GThT....PAQTVTLGDETYQVMSACKPHD.CGSQRIAVhWSEKSsQ...MoGLF........SoID...EKTSQEKLTWLNVs...DALSID.GKTVLFAALTGSLE.NHPD............................	1	8	17	29
+8650	PF08817	YukD		WXG100 protein secretion system (Wss), protein YukD	Mistry J, Desvaux M, Burroughs AM, Iyer LM, Aravind L	anon	pdb_2bps	Family	The YukD protein family members participate in the formation of a translocon required for the secretion of WXG100 proteins (Pfam:PF06013) in monoderm bacteria, with the WXG100 protein secretion system (Wss). Like the cytoplasmic protein EsaC in Staphylococcus aureus, YukD was hypothesized to play a role of a chaperone. YukD adopts a ubiquitin-like fold [1]. Usually, ubiquitin covalently binds to protein and flags them for protein degradation, however conjugation assays have indicated that the classical YukD lacks the capacity for covalent bond formation with other proteins [1]. In contrast to the situation in firmicutes, YukD-like proteins in actinobacteria are often fused to a transporter involved in the ESAT-6/ESX/Wss secretion pathway [6,7]. Members of the YukD family are also associated in gene neighborhoods with other enzymatic members of the ubiquitin signaling and degradation pathway such as the E1, E2 and E3 trienzyme complex that catalyze ubiquitin transfer to substrates, and the JAB family metallopeptidases that are involved in its release [7]. This suggests that a subset of the YukD family in bacteria are conjugated and released from proteins as in the eukaryotic ubiquitin-mediated signaling and degradation pathway [7].	27.00	27.00	27.10	27.00	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.57	0.72	-3.42	54	869	2012-10-03 10:59:06	2006-05-12 16:23:53	5	3	548	2	159	472	11	79.60	27	25.86	CHANGED	shscVslph........sp....p.thDlsLPsplPlppllsslhphls..........hsshs...........tss....phpLs....tsGt..hLstspoLsptsVtDG-lLhlh	..............hscVTlth........sp.....p.phDlslPutlPlcsllstllchls..............hshh-.............sss.h..phplt....spGt..hLstspsLs-hslsDGDlLtL.......	0	48	107	141
+8651	PF08818	DUF1801		Domain of unknown function (DU1801)	Bateman A	anon	PSI2 target AAO81511.1	Domain	This large family of bacterial proteins is uncharacterised.  They contain a presumed domain about 110 amino acids in length.	27.20	27.20	27.20	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.52	0.72	-3.93	150	1704	2009-09-12 22:25:29	2006-05-15 11:59:35	6	10	1072	5	545	1425	322	100.10	20	67.93	CHANGED	tt+pthppL+pll.tpsssp....h.pcplpa.......uhPsath..ttp................hsthss..hKp..alulhh....hpss.hp.........c..tt.l......ptphs+shhphpph.p.cls....hphlpphlppslp	...............................hppthppl+pllhpsssp................l.pEpl..pa........shPsash.sup...............sllthps.......hKp....alulha........tpu..u.lp..........c..tphl.t........phpt.s+sh.chp.ph....p.pls.....hchlpphlptsh.t.................................	0	237	402	491
+8652	PF08819	DUF1802		Domain of unknown function (DUF1802)	Bateman A	anon	PSI2 target	Domain	The function of this family is unknown.  This region is found associated with a Pfam:PF04471 suggesting they could be part of a restriction modification system..	25.00	25.00	57.80	45.90	24.20	19.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.02	0.71	-4.66	27	227	2009-01-15 18:05:59	2006-05-15 13:54:39	6	3	145	0	55	187	29	162.40	53	84.40	CHANGED	hALKEWssslcALtpGcphlLlRKGGIpEt.p..F....psptppFlLaPTh.Hpps....ctl+scapshlpts..st.tscplplpuaAplsssh.lss....ptlppLpshaIWstctlp.pRhpa+spp.lhlLlLRla.LscPhplshssp.atGCpSWlsLsp.l..shpsspPVlsDppasphtppl	.........s.ALKEWuAAV+ALl-GRQoVLLRKGGItE+.R....F........cVAu+cFLLFPTVuHoHA..............ERVRPEH+DL.....LsPA....AADS..T..-E..s..VlLRAuA+VVAAlsVsR...PEu..L-AIEcLHIWTAESVRuDRLDFRPKH+LsVLVVpshsLsEP....Vc..lscpP-.YuGCp........SWVpLs......l...ssphutPVhs-sshschstc.h.............................	0	22	41	53
+8653	PF08820	DUF1803		Domain of unknown function (DUF1803)	Bateman A	anon	PSI2 target AAO81393.1	Domain	This small domain is found in one or two copies in proteins from bacteria. The function of this domain is unknown.	23.70	23.70	23.80	24.50	22.20	23.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.21	0.72	-4.28	14	715	2009-01-15 18:05:59	2006-05-15 15:21:35	5	2	417	0	49	356	0	91.70	36	69.98	CHANGED	lpsa.hphhpppPh......hhcLl.....pYhhca..sshlL+.l++cashpc+hDhhl-shlthGYIhp.Es++YpLshsl...........................................Dp-uhhath	...........h.p.h..phhpp.sh......hhsll.....cYhhcY..sshlL+.lK+phs.ppshDhhl-phlthGaIlp.Es++YpLshsh..............................s....................t..........................	1	5	11	29
+8654	PF08821	CGGC		CGGC domain	Bateman A	anon	PSI2 target AAB98576.1	Domain	This putative domain contains a quite highly conserved sequence of CGGC in its central region.  The domain has many conserved cysteines and histidines suggestive of a zinc binding function.	21.50	21.50	22.90	37.20	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.95	0.72	-3.97	31	185	2009-01-15 18:05:59	2006-05-16 15:44:05	6	2	147	0	77	174	5	106.50	31	88.27	CHANGED	KluIlpCppsp-..h.CsG....ssCFKuhpp+puuFppap.p..sElluFhsCGGCs.........ucclhppscphh.cpss-....slHLuoChhts.............CPp..hcphpchlppch..sl.pVltGTH	.....KluIltCppsps..h..CsG....ssCh+uhpp+puuFppYsp.c.h-lluFhsCGGCs.........upplh....p......pscph......h...cps.s-......sIHluoCht...ptt..............CPp..hcphpchlpcch...Gh.plVpGTH...........	0	37	67	74
+8655	PF08822	DUF1804		Protein of unknown function (DUF1804)	Bateman A	anon	PSI2 target CAB84459.1	Family	This family of bacterial protein is uncharacterised.	29.00	29.00	29.60	31.50	28.50	27.30	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.76	0.71	-4.51	12	154	2012-10-04 14:01:12	2006-05-16 15:50:41	6	2	139	0	18	111	2	157.70	37	93.63	CHANGED	M.AHspEsRctlRphYVhsphoLEhAAhpsGVshuTARRWKpcA+spGDDWDKsRAA.tlAuGGlE-luRphLssallQapsTMctLp...pspslssuc+sclLASLuDuasKTluAs...+RlhPETscLAsAl-llphlusalpp+aPpHl.AasElLEPFG.plpKca	.....................MAaspch+cthRchYlhsphsLptuAthhsls.sTARpWKptsctcG...DDWDKhRsAphLAu.ssl-clupulltuFh...hQhpssh-plp.......sspchsspcKschLAuLuDuFoKhhuuu...++lhP-oscLusAhcllc.h.lhualppc+Pcplsshl-lLEshu..ltc.............................	0	4	9	15
+8656	PF08823	PG_binding_2		Putative peptidoglycan binding domain	Bateman A	anon	DUF1028 C-terminus	Domain	This family may be a peptidoglycan binding domain.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.59	0.72	-3.88	9	96	2012-10-01 23:43:47	2006-05-16 17:46:52	6	6	94	0	51	368	46	69.20	26	22.05	CHANGED	hhhcp.cs.tphslscDhtsplpsuLtcLGY...........ppthtcALpsalthpNFEs+.............hpscsp.IspsVhpaL	..........................................pstphhslsschtpplpphLpchGa..ht..t.....s........h.spshppALpsahuhENhEpR.....................htsss..ID.tVLphh..............................	0	23	36	46
+8657	PF08824	Serine_rich		Serine rich protein interaction domain	Mistry J	anon	pdb_1z23	Domain	This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate).  This domain folds into a four helix bundle which is associated with protein-protein interactions [1].	21.00	21.00	21.00	21.20	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.95	0.71	-4.52	12	250	2009-01-15 18:05:59	2006-05-17 14:37:00	5	8	78	2	110	232	2	155.60	43	19.69	CHANGED	LDL-sAhEpLs+LQpplsSSVutLhsFVu.....ssWRshsp.hEsslpcl+tAs-+lctul+-hL-Fu+GshusAsphsDpsLpsKl+cQLQplc-uaQhLlctppsLDsss.WohphLsts.tsps.....ssDDL-RhlhsARslP-DsKphAShltuNupLLF+Rssp	..............L-L-sAlEpLtRLQ......pslssoVupLhshlu.....ssWRs.hs....hEsplp-l+sAls+Vcsul+-hL-F.A+GAluNAup.....hsD.......psLpsKLp+QLQ+lEDuaQhLhppupsL-sss..WulshLshs...t..s...............ssDDLDRhVhsuRsVP-DsKQLsShl......p............uNApLLF++s..s...........	1	20	31	61
+8658	PF08825	E2_bind		E2 binding domain	Mistry J	anon	pdb_1y8x	Domain	E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades.  This is an E2 binding domain that is found on NEDD8 activating E1 enzyme.  The domain resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains [1].	20.30	20.30	20.40	21.90	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.69	0.72	-4.22	24	285	2009-01-15 18:05:59	2006-05-17 16:11:40	5	11	231	29	198	288	4	85.70	38	19.97	CHANGED	lphssshTLp-lI-pLscpschQl+pPSls.....sss+sLYhtss..spLEctT+sNLs+pLt-L.lpcGpElsV.........oDsshs.hshplplpFp	..........hphssssoLp-ll-hL..sp.ps..ph..QhKsPulo.......ucs+oLYhpss..sslEE..pTRsNLsKsL....p....E.....L.....l.......t-GpE........lsV.........sDsshs..tshph+LpF...............	0	70	109	164
+8659	PF08826	DMPK_coil		DMPK coiled coil domain like	Mistry J	anon	pdb_1wt6	Domain	This domain is found in the myotonic dystrophy protein kinase (DMPK) and adopts a coiled coil structure.  It plays a role in dimerisation [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.93	0.72	-4.07	6	271	2009-01-15 18:05:59	2006-05-17 16:41:07	5	15	56	3	115	239	2	59.70	48	4.79	CHANGED	ELQSALEAEIRAKQulp-ELpKVKsuNlshEsKLp-oEsKNpEL.pElcpL+K-MEE.hRuc	..................ELQSAL-AEIRAKQulQEEL.p.c.V+suNlphEs+L+-uEt+Np-L.pElcpLpcchE-.hRuc........	0	12	19	55
+8660	PF08827	DUF1805		Domain of unknown function (DUF1805)	Mistry J	anon	pdb_1qw2	Domain	This domain is found in bacteria and archaea and has an N terminal tetramerisation region that is composed of beta sheets.	21.40	21.40	21.40	30.20	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.46	0.72	-4.17	18	202	2009-01-15 18:05:59	2006-05-17 17:03:56	6	1	201	1	63	138	3	62.30	62	62.88	CHANGED	hCGhLsVsshp+......hG.sAu+Vp......GVcTl-DhLpuplhsloptAccLGlcsGMoGcEALp+h	.....................MCGALDVuLLNEKL..tDRGIIAGRAV......GVRTIEQLLEAPLESVThtAEsLGIpsGhhG+EALLKM.	0	19	45	50
+8661	PF08828	DSX_dimer		Doublesex dimerisation domain	Mistry J	anon	pdb_1zv1	Domain	Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila.\	    The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor [1].	20.70	20.70	20.90	39.70	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.98	0.72	-4.44	11	105	2009-01-15 18:05:59	2006-05-17 17:27:46	5	3	47	6	15	114	0	59.40	55	18.06	CHANGED	lspDslL-pCQ+LLEKF+YPWEMMPLMYVILKsAcuDl-EASRRI-EGphllppYppppphs	....spDhhL-aCQKLLEKF+YPWEMMPLMYVILKDAsADlEEASRRI-EGptllNph.p.p.............	0	4	8	12
+8662	PF08829	AlphaC_N		Alpha C protein N terminal	Mistry J	anon	pdb_1wym	Domain	The alpha C protein (ACP) is found in Streptococcus and acts as an invasin which plays a role in the internalisation and translocation of the organism across human epithelial surfaces. Group B Streptococcus is the leading cause of diseases including bacterial pneumonia, sepsis and meningitis.\	 The N terminal of ACP is associated with virulence and forms a beta sandwich and a three helix bundle [1-3].	20.20	20.20	20.30	30.40	19.80	18.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.26	0.71	-4.96	5	46	2009-01-15 18:05:59	2006-05-18 09:50:22	5	22	21	2	1	51	0	177.50	50	32.35	CHANGED	VTQGQlNIFs-TVlAAEVIsGSAATLNTulTKNlQNGNAYIDLYDVKNGKIDPLQLIVLsPsuYoApYYI+QGuKYYosVSELQTsGuAoITYNILcEDGsPHsKoDGQIDIVSVuLTIYDSTsLRDKI-EVcsNANDPKWSDGSRDEVLTGLEsIKsDIDNNPKTQoDIDNKIlEVNELEKLLVl..slPDKDKY	...............hTQsphNI.p-olhAApsIsGSA.sTLNTshTKNlQNGpAYIDlYDVK.GhIDP.pLIsLss.uYoApYYI+QGucYao..sssclpoTGuAoITYslLDcsGsPapKuDGQlDIVSlslTlYDoosLRspI-EVhppAsDPKWS-GSRDEVLpuLEcIKpDIDNNPKTQsDIcsKIsEVNplEKhLss...hPDt.K..............	1	0	0	1
+8663	PF08830	DUF1806		Protein of unknown function (DUF1806)	Mistry J	anon	pdb_1njh	Family	This is a bacterial family of uncharacterised proteins.  The structure of one of the proteins in this family has been solved and it adopts a beta barrel-like structure.	19.60	19.60	19.60	25.00	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.62	0.71	-4.28	14	377	2009-09-10 16:05:25	2006-05-18 10:39:37	5	2	372	1	40	133	2	115.10	62	96.23	CHANGED	csIppppVQphL-pFsN+sVYlHLETTNGAYAuHaD-ph.aosGAaIRNAplpYc+uKIs.GsG.PYRVGLKh..stGWlYAEGLTcaElD-psRLLlAGHs.pG+LAlALEIScpPFs	..........................pPIccp-V.chLsoFtpKPVYLHlETTNGAYAsHFDp+s.FsAGsFlRNhplTYp+AplK..Gsp..PYRlGLKL..stGWVYspGLTHaE..Vs-+-chLlAGashEGpLAsALpIScpPFs.	0	13	25	34
+8664	PF08831	MHCassoc_trimer		Class II MHC-associated invariant chain trimerisation domain	Mistry J	anon	pdb_1iie	Domain	The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers.  This domain is involved in trimerisation of the ectoderm and interferes with DM/class II binding.  The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules [1].	25.00	25.00	55.00	55.00	21.50	18.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.71	0.72	-4.13	10	94	2009-01-15 18:05:59	2006-05-18 11:36:40	5	6	54	3	27	80	0	70.80	51	27.02	CHANGED	NhTEDQV+HLLhpuDPhKhaPpLKsohhsNLKsLKsoMsssDWKsFESWMHpWLLFEMAKsshs-.cPsphPA	....NhTEDpVhHLLhpuDPhKhaPpLKsoF.-NL++LKpoMpshDWKsFEoWMHpWLLFEMu+pshpp.cPTthP...........	0	1	2	11
+8665	PF08832	SRC-1		Steroid receptor coactivator	Mistry J	anon	pdb_2prg	Domain	This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding [1].  The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.	25.00	25.00	33.60	33.60	18.90	18.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.00	0.72	-3.23	10	234	2009-01-15 18:05:59	2006-05-18 11:48:35	5	17	49	173	84	190	0	82.50	50	6.17	CHANGED	Kupp....KLLQLLTopo-pht......shtsusssssKDuhus........ussSssuussosso...........SLpEKHKILHRLLQsusSPsDlAKLTAE	......................................Kupp....KLLQLLToso-pht................hs.u.s.lssssKDusus............sussSusu.ussoSsS.............................SLpEKHKILH+LLQsGsSPsDlAKlTAE......	0	3	9	31
+8666	PF08833	Axin_b-cat_bind		Axin beta-catenin binding domain	Mistry J	anon	pdb_1qz7	Domain	This domain is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex.  It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin [1].	20.00	20.00	20.20	20.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.42	0.72	-4.25	9	177	2009-01-15 18:05:59	2006-05-18 13:19:08	5	6	76	1	81	150	0	40.50	58	5.22	CHANGED	EDsPpuILD-HVSRVh......+TPGspSPss........hp+ps..tupSP-s	....EEsPpoILD-HVpRV.h......+TPGCQSPGs.........upass..tpRSP-..........................	0	16	23	47
+8669	PF08837	DUF1810		Protein of unknown function (DUF1810)	Mistry J	anon	pdb_2d2y	Family	This is a family of uncharacterised proteins.  The structure of one of the members in this family has been solved and it adopts a mainly alpha helical structure.	25.00	25.00	25.90	25.90	23.10	16.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.82	0.71	-4.60	44	312	2009-01-15 18:05:59	2006-05-19 14:32:37	6	6	292	1	118	297	33	135.90	48	84.13	CHANGED	sDs..acLpRFVpAQss..lYspslsEL+sG+KpSHWMWFlFPQlpGLGpSshAp+YuIsShsEApAYLsHPlLGsRLhEsochllshpucosppIFGsPDshKh+SSMTLFutsss....ssssFppsL-paasGp.DstTlphLs	.........................sa-LpRFVpAQps.........lYppslsEL+uG+KpoHWMWFlFPQLcG..LGpSshAp..pYuIuul-EApAYLtHPlLGsRLcEssphlht.l.p.s.+.o..sppIF..G.s.PDshKhpSSMTLFutsss............ss..ssFttsLs+aasGp.DttTlphL.s..........................	0	45	76	98
+8670	PF08838	DUF1811		Protein of unknown function (DUF1811)	Mistry J	anon	pdb_1sf9	Family	This is a bacterial family of uncharacterised proteins.  Some of the proteins are annotated as being transcriptional regulators (see Swiss:Q4MQL7, Swiss:Q65MA2).  The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.	20.60	20.60	21.00	60.70	20.30	18.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.33	0.72	-4.06	15	365	2009-01-15 18:05:59	2006-05-19 16:33:10	5	1	364	2	38	123	0	100.90	62	97.01	CHANGED	-KRYS-MocaELcpEIAtLpEKARKAEQhGhlNEaAVhERKlhMAcAYLlDPs-FcsGchYclc.sssphF+lcYLNGVFAWGaRhs....usppEEALPISLLpc	....K+hSEMSE.ELRcEIplhKEKh.R.KAE.pGIlNEYDVYppKllhAcSYLl.DhpKlcIGcIY+Ls-GospYFKV-hLKGlFAWGaRhs......SDcsEEGLPIuLLQ.h.	1	11	23	32
+8671	PF08839	CDT1		DNA replication factor CDT1 like	Mistry J	anon	pdb_1wlq	Domain	CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin.  Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin.  This region of CDT1 binds to Geminin [1].	21.70	21.70	21.90	21.80	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.01	0.71	-4.30	11	217	2009-09-10 23:23:53	2006-05-19 17:18:32	6	4	153	3	161	226	0	153.10	25	25.92	CHANGED	LPhKYchLtEhFcslDolsshhcpRscphTFsp.lptsVQchs+KpFs.sHLuQIKplaPpuhplc........p.phhsaspsopp.hYpLpIc..lst.............................................tsssppphsssphhpRtplF+phLl-hsKppcptaL.p..s.s....pp.l...thps.Fpl-p.s.-ls.ucLPp	.......................LP.caphLt-hFcsh-......olls...hLp.sR...pc.s.s.TFsp.lppsVpphh.+......+.pFp..pcluQIKtlhPp.uhphc.......................tt.h..thppts...p.p....hp..l...hlp..htt......................................................................s.t..p..hs..tp.h.hht....ctphFpptLlphlpppcpt................................................................................................................................................................................................................................................	0	55	89	133
+8672	PF08840	BAAT_C		BAAT / Acyl-CoA thioester hydrolase C terminal	Mistry J	anon	Pfam-B_4571 (release 20.0)	Domain	This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.15	0.70	-4.63	24	605	2012-10-03 11:45:05	2006-05-24 14:29:18	6	14	292	4	300	3028	585	192.20	24	50.28	CHANGED	lcLEYFE-AlsaLhpHPpVptstlGllGlShGu-lsLuMuuah+..plsAsVsINGosssshsshha+t..............slsslshshpclph..........stsshhphhchhpshhspssppshIPlE+u..csshLhlsGpDDpsWtSthaAc.hpc+LpppG+c.pspllsYPsuGHhIEPPYhPhstAshthhhs......hhaGGEs+sHAhAQ.DuWpcl.tFF+KHLsu	.......................................................................................................................................LEaF-c.....Ah.pal..h.p.p.s....p..............l.p.....s.s..t.lGlhGhS+Gu-.ls.L.h.hA.u.......h...ht.........pl.s.....s...s....V........s....l....s.....s...u.s...s...s..h.t..s....h...h.h.ct.t................................................ls...l....h..p..h..p.p..h..ph......................................p.s.sh...h..t..h.h..........h...h.....t..................t.....t.........t...p.......p...s..h.....I.........s......l...E....ch..........pus.hLh.....l.s...............G.p..DD.p...W.s..S...t.....h..u...p.h.....pp.Lp.t.p.....s.p.p....p...hph.l..pY.......................suG..H..h...l....p..s.P.....a.h.P.h.p....h.sh...................hhhGG.pstspuh..Ap.cuWtph.tFhppth..s..................................................................................................................................................	0	52	103	210
+8673	PF08841	DDR		Diol dehydratase reactivase ATPase-like domain	Mistry J	anon	pdb_2d0o	Family	Diol dehydratase (DDH, EC:4.2.1.28) and its isofunctional homologue glycerol dehydratase (GDH, EC.4.2.1.30) are enzymes which catalyse the conversion of glycerol 1,2-propanediol, and 1,2-ethanediol to aldehydes [1].  These reactions require coenzyme B12.  Cleavage of the Co-C bond of coenzyme B12 by substrates or coenzyme analogues results in inactivation during which coenzyme B12 remains tightly bound to the apoenzyme.  This family comprises of the large subunit of the diol dehydratase and glycerol dehydratase reactivating factors whose function is to reactivate the holoenzyme by exchange of a damaged cofactor for intact coenzyme.	24.60	24.60	24.60	24.70	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.90	0.70	-5.61	12	375	2012-10-02 23:34:14	2006-05-24 16:49:07	5	1	324	6	39	285	7	314.90	70	55.80	CHANGED	pV-lspGA-tIMpslstssslpclpGEsGTNlGGMLE.+VRQsMAsLTspsss-IhIQDLLAVDThlP.pVpGGlAtEFShEpAVG.IAAMVKuD+LQMphIApplcpclshsVclGGsEAEhAIhGALTTPGTspPLAILDlGAGSTDASIIspcsplsAhHLAGAG-MVTMlIsoELGLpshtLAE-IK+YPLAKVESLFplRHEDGsVpFF-pPLssslFARVVllKp.sshlPl.suphSlEKI+.lRpsAKc+VFVTNslRAL+pVS..PTGsIRDIsFVVLVGGSALDFElPQhVT-uLu+aslVAGRGNIRGhEGPRNAVATGLlLsaspc	........................................................................cVDVAtGAEAIMcAVsuss+L-NloGEsGTNIGGMLE.+VRQTMA-LTsKs......ss-IaIQDLLAVDT.VPVsV.............pGGLAGEFShEQAVG.IASMVKSDRLQMAhIAp......EIc..p+LslcVplGGAEAE.......AAIlGALTTPGT.s+PLAILDLGAGSTDASIINscGEIl..AT.H.L.AGA..G....DM....VTMII......spELG.L-.DRYL.....AE-IK.KYPL.AKVESLFHlRHEDGoVQFFssPLsPsVFARVs.l.VK.P.DcLVPl..PGDlsLEKlRslRRSAKERVFVTNALRAL+pVS..PTGNIRDIPF..VVLVGGSSLDFElPQLVTDALuHYpLVAGRGNIRGoEGPRNAVATGLlLuapp................................................................	0	14	21	30
+8674	PF08842	Mfa2	DUF1812; Mfa;	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2	Bateman A	anon	PSI2 target AAO79331.1	Family	This family of proteins may be lipoproteins principally from bacilli.  They are between 300 and 400 residues. Many Bacteroides-like bacterial species, including Porphyromonas gingivalis, the causal agent of periodontal infection, carry at least two types of fimbriae, namely FimA and Mfa1 fimbriae, following the names of their major subunit proteins [1]. Normally, FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells; however, in the absence of Mfa2 protein, the Mfa1 fimbriae are also very long and are not attached. Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells to the extent that Mfa2 is located on the cell surface and probably associated with Mfa1 fimbriae in such a way that it anchors the Mfa1 fimbriae to the cell surface and regulates Mfa1 filament length [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.11	0.70	-5.05	87	437	2012-10-02 11:46:57	2006-06-01 18:05:17	5	5	93	5	62	421	4	277.90	14	80.67	CHANGED	hs.sCs...............shtlphp........ashs...............ttssshspplpplslalFD.....t.sGp.hhpphshpspplt.....tt...............................hh.tlssG.p...Ypllsau........sh.......pppt..................hsssssl...sclphplpp............tssthst......phssLa....aGph..shsh...........tstpppphslsLh+sssplpl..........hlps...........t..s.shsshp......hplpssssph...sassph.....hsspshsahPh...........tt.ssssss..................hhsph.sshphhpsp....thpl....pltppssstph......phs.h..h...............hsspthlsppsph...sl.hhh......................st.......................hssplpls.sWthhtps	............................................................h.l.h...........h..t...............t.spthtpplpplplalFD.........p..sGp..hltphphp..sppht.............tt.................h.h.............hhplssG.s...Yp.hlsau..............sh........sspt..hs..........................hsssssl..............pchhhphpp..............tsshhst.........phssLa.............aGph..shsh.....................tssttpphslsLh+sssplpl................hlps....................shss.hp................h.pltss.ssth.........shssph......sspshtahsh.....................htt.psptst............................hhsph..pshphhtsp.........................thpl.......plhtpssstth.....hp.s.h..h..........................s.p...lst.ppph....l..hhh...................................t......................hthtl.ls.sW.hh.......................................................................................................................................................................................	0	13	47	62
+8675	PF08843	DUF1814		Nucleotidyl transferase of unknown function (DUF1814)	Bateman A	anon	PSI2 target CAD86002.1	Domain	This large family of proteins are largely uncharacterised.  Some are annotated as abortive infective proteins but support for this annotation could not be found. This family was recently identified as belonging to the nucleotidyltransferase superfamily [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.54	0.70	-4.58	177	2210	2012-10-02 22:47:23	2006-06-02 11:52:52	6	12	1271	0	615	1962	254	226.00	14	83.81	CHANGED	thLtplh.....sthtpphs.hKGGTuLshh.h......hh....RhScDlDhhhht...................ttphpph.....hptlppth............................................sshthphpthhtts......................................st.ptplcl-lsht.........h..st.h..hsh.............................shshpclhucKltAhhp..................................th.RDhaDlhhl.........................htttththtphhps.h...........ht.....phppp....tpthhtphth................................................phhpp.htt..tt...........................................phpthhpp	.................................................................................................................................h.....h........htpphh.hpGGoulshh.t......h.t.......R.hotDlDhhhh......................................php.ph............hptlp..phh................................................................pt..hhhphpthhtt..........................................................t..tttlpl-lsht.........................sht.h...hthh...t.........................tl......shsh..tph.hupKltuhhp......................................tph.+DhaDlhhl...............................tttths.tthhpt.h.......................................ht.t...............................................................................................................t............................................................................................................................	0	204	415	530
+8676	PF08844	DUF1815		Domain of unknown function (DUF1815)	Bateman A	anon	PSI2 target ZP_00111304.2 (BIG_33)	Domain	This presumed domain is about 100 amino acids in length and is functionally uncharacterised.	25.00	25.00	26.00	76.70	23.10	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.41	0.72	-4.42	11	59	2009-01-15 18:05:59	2006-06-02 11:56:19	5	1	57	0	24	60	27	102.00	69	88.83	CHANGED	FhRLA-QYRshVQDLVMSLQALApuLcppGhsASCYoC....Gc-hcuASFhssLG-sHhlRFLVSDaGISWsE.RssRELVKLEGAEAIpcLQclAshl+pspsssu	FhRLApQHRpFVpDLVMsLQALAhlLEpRGYhASCYTC......GsphNSASFMVSLG-sHLIRFLVSDYGITWTEMRDDRELMKLEGAEAIsQLQELAsLlKhp....ss....	0	3	15	22
+8677	PF08845	SymE_toxin	DUF1813;	Toxin SymE, type I toxin-antitoxin system	Bateman A, Eberhardt R	anon	PSI2 target AAC77303.1	Domain	SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin [1,2].	20.70	20.70	21.00	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.80	0.72	-4.12	23	839	2012-10-01 20:57:08	2006-06-02 12:01:30	5	3	449	0	149	526	5	49.20	39	50.52	CHANGED	tRhhTV.....................GYs.http.t..........sPslpL+GcWLEpuGFssGp.lplpVppGpLVIps	....................................l..uYh....p..............h.....PslpLpGpWL.cpAGFsoGpsVsV+VhcGClVlp...........	0	19	51	90
+8678	PF08846	DUF1816		Domain of unknown function (DUF1816)	Bateman A	anon	PSI2 target ZP_00109395.2 BIG_34	Domain	Swiss:Q4C9H3 is associated with the Pfam:PF01383 domain suggesting this presumed domain could have a role in phycobilisomes.	20.50	20.50	21.00	35.40	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.17	0.72	-4.28	29	104	2009-01-15 18:05:59	2006-06-02 12:48:16	5	3	70	0	46	121	101	67.20	41	56.63	CHANGED	uhuNth.GLAWWs+lpTpsPssTYaFGPFlocpshctplssalpDLpsEuspsIppsllRs+........+sEsLTl	...........p.hGhAWWlcIpTppPcCTYYFGPFhopp-AptthsGYlEDLpsEGApsIphslpRCp.PcsLTl..............	0	7	32	44
+8679	PF08847	DUF1817		Domain of unknown function (DUF1817)	Bateman A	anon	PSI2 target ZP_00111140.1 BIG_36	Domain	Members of this family are functionally uncharacterised.	25.00	25.00	25.80	25.10	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.70	0.71	-4.65	21	131	2009-09-10 22:53:16	2006-06-02 12:51:59	6	2	119	0	42	100	33	134.30	40	60.20	CHANGED	plss-uIppLDLoPlpthhp.........pshsslLststsLphphsaPRs.ssDPR.ELSEhPEsRLWhlRhDApYPWLPLLL-hpsGpLsRasAMLVPHpFstsEGlpFsPEALElalhH+lFlLscahppp.Gls..ppu.pLppMAthLGY-LDsuFasLl	.......................................s.lsp-plppLDLSPlpphhc........hhptps.lhh.ppslthslpa.ps.ssDPR.ELuElPElRLWF.lRLDusYPWhPllLDhpt...GplhRasAMlVPH...........ph...p.t.G...l.a.sPpALElalhp+lh...hl.phhpp..ths..t...phtphAthhGatlssthap................	0	8	29	38
+8680	PF08848	DUF1818		Domain of unknown function (DUF1818)	Bateman A	anon	PSI2 target ZP_00110314.1 BIG_37	Domain	This presumed domain is found in a small family of cyanobacterial protein. These proteins are functionally uncharacterised.	25.00	25.00	53.90	32.60	19.30	19.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.51	0.71	-4.03	27	71	2009-01-15 18:05:59	2006-06-02 12:59:54	6	1	70	5	30	76	118	115.20	41	87.84	CHANGED	.pEGsGWRLuhDPs+spassLIGGEsWAlELTcsEhpshspLlhpLscphpsltspLMsEEpIsLElEpt.hWhpl-GptpsWuL+lILpss.......RusEGtWPAssssslstAhcplh	.l.+cGsGWRLGaDP...p.t...spassLlGu-sWAlELTcsEhs-hscLltpLspshptls..s-.L..M-EEpIshEhEsphlWhplEGhspsaoL+hILpss.......RpsEGtWPssssssLltAhppl............	0	6	20	28
+8681	PF08849	DUF1819		Putative inner membrane protein (DUF1819)	Bateman A	anon	PSI2 target ZP_00108899.1 BIG_41	Family	These proteins are functionally uncharacterised.  Several are annotated as putative inner membrane proteins.	20.30	20.30	20.60	22.60	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.78	0.71	-4.89	25	271	2009-01-15 18:05:59	2006-06-02 13:12:16	6	1	259	2	54	226	31	176.70	23	85.97	CHANGED	sppcYpsslsuGuLhlpES+plAcLhLpshsh-phccplhp-NlLQppo.uos+Rhs+pl.tpRLcoLssc.h.....phls-.usppptpplLahAsh+psplltDFhh-Vlp-+ahphchcLstcsastFhspps-hcsplsphSsSTptKLpQlla+hLtEAGhLtt..scspplpsshluscltphLpc.psppclh	............a.uslhutshhhpE.+hlspLhhps....s.pphp...ptlhpcNlhptsotsosc+hspsl.ptR.LpsLsps.hh....................phlsp.....us.pppp.lhh...huhhhps.llt-FhtcVlpcthhph...c....plstpchptFhppp.tp.ppstls.s.ao-sThp+htsshhphLt-uGh..lps....scp..c.plp....hhl..ph.thl.t.......h.......................	2	21	37	48
+8682	PF08850	DUF1820		Domain of unknown function (DUF1820)	Bateman A	anon	PSI2 target AAG07366.1 BIG_46	Domain	This family includes small functionally uncharacterised proteins around 100 amino acids in length.	20.90	20.90	25.90	25.70	20.80	18.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.22	0.72	-3.90	21	216	2009-01-15 18:05:59	2006-06-02 13:18:53	6	1	215	0	60	152	247	98.60	49	90.46	CHANGED	pslY+lhFhNpsplYElYARplhQSchaGFlElE-FlFuE+opllVDPuEEKLKsEFuGVpRoa...IPMHullRIDEVcKcGsuKIo-spst...ssVssF.Phs	..t.slY+lhFl..N.pGc.lYE.lYARplhpSs.L.aGFlEIt-FVFsp+osllVDPSEEKLKsEFsGVpRSa...lPhHuIlRIDEVc..+..c..Gsu+Io-ht.....sNVhsF.Ph..................	0	14	33	45
+8684	PF08852	DUF1822		Protein of unknown function (DUF1822)	Bateman A	anon	PSI2 target ZP_00109005.1 BIG_39	Domain	This family of proteins are functionally uncharacterised.	25.00	25.00	29.20	28.60	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.21	0.70	-5.64	27	120	2012-10-11 20:01:01	2006-06-02 13:41:17	6	3	38	0	42	154	0	290.10	19	92.18	CHANGED	l.lsssspptA.phupphssspcphpsYL.NpLAltultsWLpt...-hpsshpsssthps.lsphh-.Vsshtls.th.t+l.hlsspshps...s.lplPpEh..hsshlu..YlsVpls.-tp.sclhGalstppl.........pst.cpshplshp.......cLhs.hshLp..hstp.tss..t.....s.h.......h...lpp.Lts..hs......sap..htsLlt.st....h...p........................................................................................h.t..............hths.....tthppsttlshthplsspsh...tLhltht.pssp.phtlhhpLpsht......ssshLPsulpLpllscstpsh.pspsps....p..c.hlplp.hpsp.Gppaplclthss...hhpE.hh	..........................................................................................................l..t..p.u...p...ut..t....s.tpt.psal.NtLulhsh.taLp.........th..php..s.hps..h.phht..lssh.l.....th.h+....lthhshtt.pp...t.hpl.P.Eh..hs......phhu..YlsVpls....p.p.splhGahpt.................tt.pl.shp.....................pL....thl..........................................t.......ltp.ltt..............sap....httl...ht.......h..................................................................................................................................................t........t...hptsthlshthp.hstp..l...hLhltl....sp.spp..phtlhlplhsht.............tpthLP.slpLtllspssphh.pstspt......tsphlplp.hpsp.uppFplplthss....hpE.h...........................................................................................	0	4	33	42
+8685	PF08853	DUF1823		Domain of unknown function (DUF1823)	Bateman A	anon	PSI2 target ZP_00108651.1 BIG_42	Domain	This presumed domain is functionally uncharacterised.	25.00	25.00	79.40	78.40	24.50	17.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.47	0.71	-4.35	21	75	2009-01-15 18:05:59	2006-06-02 15:29:12	6	1	75	1	32	79	121	115.90	52	79.95	CHANGED	PLocslLhtILpD+lSDthVspLlWp+LGYphcs..ss...WssussoPp.Wp-caPcsPphIupRPAoV+LTRSIPKEaKQLLKcpLGFpGY+IuELhPRRTRRATAVNWLLualtpp	..PLsp-slhtILs-clsDphVspLVWphLGYRh-tsp.sp........WssupVssp.Wp-cYPcPPshIs.s............R............P...AoV.....+LTRSIPcEpKQLLKEp...L...GFcGY+IGEhsPRcTRRATAsNWLLuahtp.p...	0	8	22	31
+8686	PF08854	DUF1824		Domain of unknown function (DUF1824)	Bateman A	anon	PSI2 target BIG_44	Domain	This uncharacterised family of proteins are principally found in cyanobacteria.	25.00	25.00	36.00	42.20	17.80	18.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.51	0.71	-4.50	23	72	2009-01-15 18:05:59	2006-06-02 15:34:20	5	1	72	3	32	77	106	124.00	34	83.93	CHANGED	lspLpDLspLRsA....PpLssspccpLtpELpthhssu-WhTlGlMAPSsppAlpALRshppthuast....hpsh-.....pspt-G.sVFLKuNQpoGslalRsEpGLGcGlLlosptsccspsusTaGPLPLDhF	....................phLp-hssLcht....s.ls.sppccpL+ptLhhhhstu-....a..........slGIhAsosppAltAL+shppuhuatt......hps.....s.......tss.-G.sVaLKhNppoGshalcs.sGht+GVLlSCQusp....ss..t.ssTaG.hPLDhF...	0	7	21	30
+8687	PF08855	DUF1825		Domain of unknown function (DUF1825)	Bateman A	anon	PSI2 target BIG_45	Domain	This uncharacterised family of proteins are principally found in cyanobacteria.	25.00	25.00	29.10	38.50	24.60	21.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.47	0.72	-4.05	12	99	2009-01-15 18:05:59	2006-06-02 15:37:52	5	1	99	0	33	86	318	104.30	55	89.98	CHANGED	Mu.FF-SEIVQpEA+plFp-YQpLhplGupYGpFDREGKhhaI-pMEpLh-R.+lFhKRhELS..DDF.ApMshcQlcsQLstFGhoP.p...pMF-QMspTLE+MKsphc	........Mu.FF-SEIVQpEAKpLFpDYQpLhpLGuc..YGKFDREGKKhFI-pMEsLM-RY+lFMKRFELS..EDF.AphTlEQL+TQLuQFGhTP.p....QMF-QMstTLERMKspl.........	0	8	23	31
+8688	PF08856	DUF1826		Protein of unknown function (DUF1826)	Bateman A	anon	PSI2 target BIG_48	Domain	These proteins are functionally uncharacterised.	20.70	20.70	21.10	21.20	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.41	0.71	-4.55	50	214	2009-01-15 18:05:59	2006-06-02 15:45:18	6	1	195	0	63	230	227	184.90	32	84.78	CHANGED	shussPslLssIhps.ssNlAlWpRpLssplppalstllsp.p.sshphthsltsspsshcshppths....sspttpsLhpDluhLlchFssLhshcplGLRLclLcpsMCPRFHVDpVPsRLlsTYpGsGTpWLtptsssRstLG...t...sp.........tpIpplssG-VALLKG-tW.G.NEssGLlHRSPsh..s....sGcpRLLLoLD	.................................................................................................h.stpstsLsplhps.slNlulWpRplsstltphhs.th...ht.t....sh.th.hsh.........tt....t...ht....h.tths...................sh.shpshltDlshLspha....s....sLh..shc..plGLRLcsls...psMCPRFHVD+VPs...R.....Lls..TYtGsGopWLtpsshsR....p..L....u..th.ttt..spt.................................spIpplssG-VALLK.Gc.p..W.......G......N...........cst............GL.....lHRSPsh...s........ss.ptRLlLoLD......................	0	19	37	54
+8689	PF08857	ParBc_2		Putative ParB-like nuclease	Bateman A	anon	PSI2 target AAG07772.1 BIG_47	Domain	This domain is probably distantly related to Pfam:PF02195. Suggesting these uncharacterised proteins have a nuclease function.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.22	0.71	-4.41	15	262	2012-10-01 20:12:50	2006-06-02 16:09:00	6	2	211	6	96	234	41	170.00	34	65.27	CHANGED	pllplslssLRPTQhsVGhtEVptKppcap....................cppc.ppppc....aLcsHhl.........................................PVVlGPsu.phallDHHHlsRALh-hGspp.................VhspVluDLSsl.spssFWphMcsptWVaPaDs+Gp.++shspLPcslt........sLcDDPYRSLAuhL+ptGuacKss..sPasEFtWAcaLRc+	.............p.hh.lplspL+PTQhslGhcpVttKtt+ap....................thst..+phps.......ah..ts+hl................................................PlVlGP.........sG.phYlsD+HHhhpALh-t.s..ssp................................Vhs...h.V..hs-Luth...ststFWptMppppWla...hD...scGt.phs....hspLPssLs..........................sLpDDPYRSLuhhlRctGhhtcss................ssF.EFhWADaLRp.........................	0	21	40	70
+8690	PF08858	IDEAL		IDEAL domain	Bateman A	anon	Bateman A	Domain	This short domain is found at the C-terminus of proteins in the UPF0302 family.  The domain is named after the sequence of the most conserved region in some members.\	 The function of this domain is unknown.	20.40	20.40	20.80	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.54	0.72	-4.46	42	993	2009-01-15 18:05:59	2006-06-02 16:24:31	5	2	543	3	101	402	1	36.70	34	26.17	CHANGED	hLccslt.....phpcccLhppIDpALDp+DcctFhpLoppL	....................lpcthp.....phphcpLhppIDpALpppDcptFhpLopch......	1	34	67	85
+8691	PF08859	DGC		DGC domain	Bateman A	anon	PSI2 target BIG_49	Domain	This domain appears to be a zinc binding domain from the conservation of four potential chelating cysteines. The domain is named after a conserved central motif. The function of this domain is unknown.	21.50	21.50	23.30	23.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.39	0.72	-4.20	39	205	2009-09-11 06:56:43	2006-06-02 16:29:11	6	3	167	0	104	181	5	108.80	32	79.43	CHANGED	shlasCSGsSs.sGQluNpsAlcLscpG.h...uchhCluuluupssslhchAcuuctIluIDGCslpCup+sLppsulsscpalhlo.-h.........GlcKpht.tshspp-lpphh.ptltc....h	.......s.llauCSGsSs.luQlANplAlcLs+ts.h....ucMuCluGlGu.slssll+hA.+uucsllAlDGCslsCs+psLpptGlsss..tHlhLs.-h.........Gl.cKpht.....p-hs...t-hpplh.t.h...t................................	0	48	80	91
+8692	PF08860	DUF1827		Domain of unknown function (DUF1827)	Bateman A	anon	PSI2 target BIG_53	Domain	This presumed domain has no known function.	23.40	23.40	23.50	30.20	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.89	0.72	-3.88	15	568	2009-01-15 18:05:59	2006-06-02 16:42:00	5	1	513	4	43	173	0	95.60	51	94.90	CHANGED	M+LINsTNSascLVpsQLssT........DAphVcVYShGNTcVlaTcAPcHhElLIoN++RsI+-sEI-hIhEhhLK+......hspsslcsl+ss+LIEIolP	............MKLINsTN.SHspL......VcsQL-sT........DApLVEVYSAGNTcVlFTpAPhHhEILIoNK+RuIR-sEIEpIp-aFLKRhh.ptshcpssIKsla..op+LItISlP.................................	0	5	18	27
+8693	PF08861	DUF1828		Domain of unknown function DUF1828	Bateman A	anon	PSI2 target BIG_51	Domain	This presumed domain is functionally uncharacterised.	21.50	21.50	21.80	21.90	21.10	21.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.76	0.72	-4.34	22	497	2009-01-15 18:05:59	2006-06-02 16:47:38	5	2	378	0	50	221	4	89.20	31	38.70	CHANGED	TPFh..spGDtltlalcpts..sthhloD-GhTLhcLp.tGhphp..stpRt.cllpslLstaGlphps..upl.hshsstcshutshtshlQulltl	..........TPFhD.phsDpltlahptps...sp......h.pLoD-GhTlhsLE.t.Glsls..pKpRp.clhpslLps..aG...lchs-..pEI...hh...ps...s.p.cshspshasllQslltl............	0	13	27	39
+8694	PF08862	DUF1829		Domain of unknown function DUF1829	Bateman A	anon	PSI2 target BIG_51	Domain	This short domain is usually associated with Pfam:PF08861.	22.20	22.20	22.90	22.90	21.50	22.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.86	0.72	-3.70	14	377	2009-01-15 18:05:59	2006-06-02 16:50:04	5	2	271	\N	25	144	2	86.70	33	36.27	CHANGED	GpSuhpHpFDallspppppsp+hlpshsssspsthpshhasa.Ds....ppscpssschhl..Ih.NDppcplssphpphhppYslpslsaSc+	.......GcSGlhHsFDallssp+.pp.EKhlpshsNhspsplpsthhsa.Dsp....t+ppcp..cppsphhl..Il..N.......Dsp.....cs.....Is...E..cspshhcc.slpllsaSp+.............	0	8	17	23
+8695	PF08863	YolD		YolD-like protein	Bateman A	anon	PSI2 target BIG_52	Domain	Members of this family are functionally uncharacterised. However it has been predicted that thes proteins are functionally equivalent to the UmuD subunit of polymerase V from gram-negative bacteria [1].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.82	0.72	-4.13	39	1100	2009-01-15 18:05:59	2006-06-02 17:07:01	5	1	636	0	106	648	6	85.80	23	75.75	CHANGED	lPEphptlcchhp-.ppKlp.+PhLsppph-clpphlhpuhtpppplploYac.........sGhhhshhsplpplc.hppplphss..t..tpphplphpsIl..cl	...........................hsEphttlpp...-..ppKlp..+sh.Loc.p...phpclp.......h...Lp...p...u...h...t...p...p..p...t...lpl..paac............sGh.h..s.hp.hplhclst..hp.hhlpsps........pphplphtDIlsI....................................................	2	34	66	85
+8696	PF08864	UPF0302		UPF0302 domain	Bateman A	anon	PSI2 target BIG_50	Domain	This family is known as UPF0302. It is currently uncharacterised.	20.40	20.40	21.30	35.80	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.90	0.72	-4.23	21	533	2009-01-15 18:05:59	2006-06-02 17:09:35	5	2	509	3	50	197	0	105.20	42	56.87	CHANGED	cK+pFlcahLppaphKcREuhWlLNYlhsccplLppVHFV-stphss+uLhlostsscs.sFtFa+ssphhscspcsFt-lphN.s-slYlpLpFps...phpsppYls	..KcsFlcahLtpYphKpR.sVWlLNYlh...sp-shLppVHFV-..s.thtspcsLpluss.s...scsss.hpFhKpNl..phhsspchFhDhhh.N...+..s....p.s.laIQlpFts...shpptphL..............	0	18	32	42
+8697	PF08865	DUF1830		Domain of unknown function (DUF1830)	Bateman A	anon	PSI2 target BIG_56	Domain	This family of short proteins is functionally uncharacterised.	25.00	25.00	25.20	36.90	20.00	18.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.38	0.72	-4.35	26	103	2009-01-15 18:05:59	2006-06-02 17:21:47	6	1	68	0	40	121	114	67.00	43	63.27	CHANGED	CsYtNsTs+h.llRshs.ssaYhERVlFPsphhhFEAP.cApLEIassshuushLpsphssscltlsp	.CsYhNsTsplQlsRI.sNlsNaYaERVVFPGp+LlFEAsscApLEIaos.huusILs-pIsCpcLtlp.t..........	0	5	30	38
+8698	PF08866	DUF1831		Putative amino acid metabolism	Bateman A	anon	PSI2 target BIG_55	Domain	Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	25.00	25.00	37.80	43.40	22.20	19.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.30	0.71	-3.81	22	596	2009-01-15 18:05:59	2006-06-02 17:24:05	5	3	592	1	56	208	0	111.20	54	97.07	CHANGED	MAFpp.olplpGsphpYplssslK+aTL+DssFhpo+sGNapLpR.L-ssss.spuhhLKIoIscDLsuFKhslTstsGL+hVNIFKscppp.h.-paaFlhcsLl-Rplhpc	.....MAFppplpLpssphsYoLSPslKKaTL+DNsFhETKsGNYpLpRhLEpsPsS.s-GFpLKIhINK-LoGhKlsITDpsGLRhVNIFKsEcp+hpQEKFYFLMDuLVERslFsK...	0	11	26	41
+8699	PF08867	FRG		FRG domain	Bateman A	anon	PSI2 target BIG_54	Domain	This presumed domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised.	25.00	25.00	26.00	25.00	21.70	23.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.49	0.72	-3.51	73	450	2009-01-15 18:05:59	2006-06-02 17:25:37	6	4	401	0	125	417	24	102.00	26	31.55	CHANGED	tpsthlFRGp.....ust.sa..t.....LhPolhRtttph.t......................Epph..........lc..............pFccp.................................utt..hhsppss............................hchLAluQHaGlPTRLLDWTpsPLVAhaFAsps.tpts............usla	.................................................................................t....hhaRGp.......sst..pa....t....................LhPolhRtttt.................................Epphhp..............................phhpt..........................................................................................t.t..thp.p.t.....................................hchluhhQHaGl.sTRLLDhTpsPhlALaFAspsttptt.........h.................	0	33	71	99
+8700	PF08868	YugN		YugN-like family	Bateman A	anon	PSI2 target BIG_5	Domain	This family of proteins related to B. subtilis YugN are functionally uncharacterised.	25.00	25.00	27.50	26.80	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.69	0.71	-4.53	26	285	2009-01-15 18:05:59	2006-06-02 17:42:44	5	1	164	3	55	187	0	121.80	41	95.57	CHANGED	h..sSslEGpphpLpcL-plhcshGashuGpWDY-+shaDhKlspc.-G..hhaLRlPshAl-G-lsscsAllcLhoPhLh+HhY.+Gl-.t........................cDtchPpp..hlphucpllp-lccpLp	......hsopl-GtshsLshLc-lMcshGalluGp...WDYE+soaDYKh-....cs...hhaLRV.shAl....-G-l....su....p....pAhl+LhsPhLh+HhYs+Gl-hs...............................s.Dtphspp..hlphucpLlpplEccL..............................	0	17	38	43
+8701	PF08869	XisI		XisI protein	Bateman A	anon	PSI2 target BIG_57	Domain	The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required [1].	25.00	25.00	26.40	26.30	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.22	0.72	-3.95	34	213	2009-01-15 18:05:59	2006-06-02 17:46:45	6	4	37	7	71	266	3	103.50	39	97.22	CHANGED	MDpLs.pYRplIpplLpcYuph..psspsclEs............pLlhDpp+........ccYhlhslGWcspcRlausllHl-I+ssKIWIppDsTEcGIAp-LlctGlPKpDIVLGF+sPphRpaT-FAVu	................M-.p.l.p..pY+pllpplLpcYuph......tssp.spl-s....................phlhDppp........c+Y.lhplGWpsp.c.R.l.a.usllHl-I.+.ssKIWIppDsTE.uIAp-LlctGlPKpDIVLu.FpsP.hRpaT.saAl.............	0	17	52	71
+8702	PF08870	DUF1832		Domain of unknown function (DUF1832)	Bateman A	anon	PSI2 target BIG_58	Domain	This family of proteins are functionally uncharacterised.	25.00	25.00	25.20	25.70	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.31	0.71	-4.37	23	127	2009-09-10 14:48:39	2006-06-02 17:49:01	6	3	123	0	36	131	30	112.60	30	66.51	CHANGED	+l+lSppuccpLp+LKppTGlss.NllCRhAhstSLppsshsp.....stsh.sDuslEh..shcsas.....G-hsslhhslLKp+h.....s.ph.-scplhcthphHlcRGluhLtschplts....h..pll	..pl+lSppsc-pLp+L.Kp...h..T.sl.ss...NllsRhAhshSLtpsp..h.s.....s.sh....-u.slEh..shpsas...........G-hsslh..h...hlL+t+h.....shth..-pcslhpta+hHlcRGIuhLtschpltp.....................	0	5	25	34
+8704	PF08872	KGK		KGK domain	Bateman A	anon	PSI2 target BIG_60	Domain	This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	21.40	21.40	22.10	22.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.50	0.71	-3.93	9	64	2009-01-15 18:05:59	2006-06-02 18:16:26	5	2	30	0	19	58	0	107.00	25	80.45	CHANGED	s-phcptN..............scDDVl..tscp.......psaKlpclhptlcpthpschhp-h...hp..t.................sphahspGlsCElLchsspsWpKGKl+l.huLEFlPD..E.........Pphs-.ESPLDDIRppIs	..............................................................tcpsl....tp.......phhpltphhphh.t.hpp.....p..t.....h....ht............................................tpha..h...spGlcCclLphGspsWpKGKl+l...............h...........s............LEF..hPD..E..............................sp....pp.p.SPLD-lRp.h........................	1	3	13	19
+8705	PF08873	DUF1834		Domain of unknown function (DUF1834)	Bateman A	anon	PSI2 target BIG_62	Domain	This family of proteins are functionally uncharacterised. One member is the Gp37 protein from the FluMu prophage.	25.00	25.00	33.00	32.60	23.80	23.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.09	0.71	-4.71	15	142	2009-01-15 18:05:59	2006-06-02 18:25:54	6	1	131	\N	25	118	1	179.60	26	94.11	CHANGED	hIsplEpAllsRl+p...shGshl+tVso.....................asGcaD-pslsplVRphPAlaVsatGts.ts...tsucs+apssupasVhVsucslsuEpssRhG...........lYQllpslpslLtsQcl....s.hshssLp..Pppl+sLa.ssphcspG...luVYAh-Fpssh...............l-.ssLsshphsptsh...................ts.ssDhpphtlphplsssps	.................................lsphEpAllsRlcp......hhG.ph.lpp.Vco.....................asGcas-.tsltphlt..shPAlaVsahGss.......tupsRhpssucaslhVs.ucslp....ucpssR.G............hYpllpplptlLsGpph...........t.ssslp...p..pl+..sla.sssh.t.stu...lulYu..l.Fssph...............s-.ssLcs..hth..tth........................................hst...................................................	0	11	17	23
+8706	PF08874	DUF1835		Domain of unknown function (DUF1835)	Bateman A	anon	PSI2 target BIG_63	Domain	This family of proteins are functionally uncharacterised.	21.10	21.10	21.10	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.70	0.71	-4.18	25	370	2009-01-15 18:05:59	2006-06-02 18:26:58	5	4	323	0	86	318	19	119.80	25	37.51	CHANGED	lHlshussAuuoL+hAltp.t..hs-pVlsltD-LSlGPlhslcstt.thtRtpW...l.ptht.t.......pp.htpp......hhschcsthpp...lppl..ssss.plslWpucsup-plsLphlhhhLpsps.p..lphlssop	...........................lHlshusssuusL+hhltptt............hpcs.Vlsh.p-s..holGP.l.t.p.lc.s.s.t.h...htRtpW......l.pslst......................t.hpp-.......hhschcp.phpp........L.cpl..ssps..plslW.pup.sup-plhLphlhtpLc..spt.p...lp.lphs.................	0	22	51	66
+8707	PF08875	DUF1833		Domain of unknown function (DUF1833)	Bateman A	anon	PSI2 target BIG_61	Family	This family of proteins are functionally uncharacterised and are  predicted to adopt an all-beta fold [1]. They are often found in gene neighborhoods containing genes for an NlpC peptidase and a  Ubiquitin domain predicted to be involved in tail assembly [1]. 	20.60	20.60	21.60	21.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.49	0.71	-5.05	12	139	2012-10-02 17:50:33	2006-06-02 18:33:47	6	1	118	0	27	137	7	147.30	21	88.56	CHANGED	shhcphtusssschhltslEIp+sshsc......shhlVpshcDlssphEs......Gp.l.FhAhsh-lslPspssuss.slplslDNVsptlschl-tuhtsp..h.tlshRhYLsschssPp.-hshphslpsssh-shplospAGhhDlhNpthsphpa	...........................tth.ttsssph...lpslElsHPshsp..............shh.ls.p......s......hc.s.lss.ptcs..............Gp...hhatshshsl.shPsps.sststslshslsslss.l.sstlc..pshts...p.........h...plsaRhY.....lu.scls..sPt.thshshplpssshs..stslshpss.h.shhspth..........................................................	1	5	10	18
+8708	PF08876	DUF1836		Domain of unknown function (DUF1836)	Bateman A	anon	PSI2 target BIG_64	Domain	This family of proteins are functionally uncharacterised.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.51	0.72	-4.28	48	1171	2012-10-04 14:01:12	2006-06-02 18:36:12	6	2	876	0	118	656	3	95.50	36	57.32	CHANGED	.php-l...Psl.............DLYhDQVlphhsphhps..................................th.....chLTpTMINNYsKp...pllssPpc.KK..Yo+pplshLllIthLKsllolp-IpplLphhhss..........hshcphYpta	..................................................php-lPsl.............-LYhDQVlthhsphhss.................................h....p..phLTsoMlNNYVKp...thls...tP......K.....KK.....YsppplshLlhIshLK.s.l.holp-Ippslphltsp..........hs.pphYp..h.....................................	0	45	84	98
+8709	PF08877	MepB		MepB protein	Bateman A	anon	PSI2 target BIG_66	Domain	MepB is a functionally uncharacterised protein in the mepRAB gene cluster of Staphylococcus aureus.	21.80	21.80	22.60	29.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.44	0.71	-4.59	14	546	2009-01-15 18:05:59	2006-06-02 18:40:34	5	1	530	0	56	301	2	119.70	49	79.89	CHANGED	EppNs-Ycuhhhplppcp..h+hRlAKhTPsKhGhFVsFWcK.spsspNpPFshp-ss-hLlI.slhDcsppG.FlFPK-lLlcpGILpopsppGKMAhRVYPsWspsLNppApKTQpWQhpYFh-h	........EK.Np-Y-uhhFphppcs...hpsRLAKKTPpKtGYFVohWpK...D.c.s.s.pN..pPas....hcshsDhLhI.sV..........hD..-......p.....ppGhFlFP+ElLlc+sILsopppKGKMAhRlYPpWsss........LNppAppTQcWQhpYFh-............	0	24	37	50
+8710	PF08878	DUF1837		Domain of unknown function (DUF1837)	Bateman A	anon	PSI2 target BIG_65	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	25.40	25.20	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.30	0.70	-4.76	59	272	2009-01-15 18:05:59	2006-06-03 10:19:05	6	3	262	0	46	206	4	214.50	17	69.97	CHANGED	cphschlhstlscaulsp................pc..hpphtppphtthht............putpph........................sphtppG...E.hGEll.Lahllcphhss......llsKh.hKss..p.thcGsDulHlthpsst......pLahGESKh..Yss...hssA........lpsshculpphh........ppsthpp-hpllpsphp.p.........t.t.tptlpchls.spps.........pphphphshshhlsa-sshh.ph.t............tpchpcplppphppphpphtp.............hp.tthtphphplhllPl	......................................................h...l.phhhs....................c....htth.htp..h.tthht..............htphh............................stphcsG...-..lGEll.ltthl.cthh.s...h.s....h.l..s+lthKss.pshsh+GsDslthh..hs..spst......plhhuEuKh.....hts...hpsu..........lpcshsslpcp...........ppp.hspphphlpsplppp.........p.shtctlcchlp.....................tt....hthshhhhhp.t.....................th...h...h..........................................................................................	0	11	29	37
+8711	PF08879	WRC		WRC	Riano D, Finn RD	anon	Manual	Domain	The WRC domain, named after the conserved Trp-Arg-Cys motif,  contains two distinctive features: a putative nuclear localisation  signal and a zinc-finger motif (C3H). It is suggested that  the WRC domain functions in DNA binding [1].	21.30	21.30	21.40	21.70	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.59	0.72	-4.29	25	422	2009-01-15 18:05:59	2006-07-26 15:40:26	5	12	32	0	213	410	1	45.50	49	10.33	CHANGED	-sEstRC+RTDGKKWRCs+pshsspKaCE+Hhc+u+pRsp+phcs.s	.......sEPuRCRR....TDG.....KKWRCS+cshs.spKYCE+H.h...pR...G..R....pRS+K.l-..t..............	0	23	124	179
+8712	PF08880	QLQ		QLQ	Riano D, Finn RD	anon	Manual	Domain	The QLQ domain is named after the conserved Gln, Leu, Gln motif.  The QLQ domain is found at the N-terminus of SWI2/SNF2 protein,  which has been shown to be involved in protein-protein interactions.   This domain has thus been postulated to be involved in mediating  protein interactions [1].	23.30	23.30	23.70	23.30	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.04	0.72	-7.66	0.72	-4.54	43	563	2009-01-15 18:05:59	2006-07-26 15:44:28	6	26	209	0	287	521	0	36.80	41	3.82	CHANGED	ssFossQhppLcpQhhsaKhlsp.....shPlPscLhhslpp	....sFossQhppL+tQlhsYKh.Lup.....utPlPspL.hslpt.....	0	51	141	221
+8713	PF08881	CVNH	CNVH; 	CVNH domain	Bateman A	anon	Bateman A	Domain	CyanoVirin-N Homology domains are found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as filamentous ascomycetes and in the fern Ceratopteris richardii.	22.10	22.10	22.80	22.40	21.90	21.90	hmmbuild  -o /dev/null --hand HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.47	0.72	-3.81	34	277	2009-09-10 22:09:16	2006-07-26 15:50:08	5	8	82	44	218	294	10	104.10	24	56.75	CHANGED	sFppSuccI+l.....pssphLsAcspsssG.p....hhsucIcLsphlGNss........GpFhW....................................................................sGtNFoco..Acslcht...ttptsslLcApLtsscGphtspp.lsL.sE+IsNpsGpLpa	..............................Fttosp.shpl....................ssp.hLtApC.p...st..s..G..p..........hh.p.o.pl-.LNph....lG.Nss....................Gph..ph............................................................................s.s.ssFspo..s..pshplp..............ts.h.L...pup.h.......ts........p..G..t...h....h......tsp....lsL.....s.c....pl.t.NtsGpL...........................................................	0	29	118	190
+8714	PF08882	Acetone_carb_G		Acetone carboxylase gamma subunit	Bateman A	anon	PSI2 target BIG_95	Domain	Acetone carboxylase is the key enzyme of bacterial acetone metabolism, catalysing the condensation of acetone and CO(2) to form acetoacetate.	20.80	20.80	21.30	37.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.52	0.71	-4.05	24	126	2009-01-15 18:05:59	2006-07-26 15:56:01	6	2	113	0	52	118	9	111.40	52	68.55	CHANGED	Vshs-hllLsLuschalsps...........CGHcFushRcNaKhtshlasRDscEhhptl.....YsthhAPDspWppIhEYYCPpCGshh-sEhssPhaPllHDhEsDI-uhhpcWlt	.............VsacD+IlLPLGsHLalVQssp.p+..hll+C.pCGHsFsssc-NWKL+A.IYVRDTtEthcEl.....YPclhAPDspWQVhREYhCPsCGhhl-VEAsTPWYPVlHDFEPDI-sFY+-WL.G.....	1	17	31	44
+8715	PF08883	DOPA_dioxygen		Dopa 4,5-dioxygenase family	Bateman A	anon	PSI2 target BIG_92	Domain	This family of proteins are related to Swiss:P87064 a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.	25.00	25.00	33.20	32.80	23.50	21.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.61	0.72	-3.95	44	382	2010-01-08 13:27:16	2006-07-26 15:58:34	6	3	347	6	160	314	37	105.30	39	76.16	CHANGED	YHAHVYF...c.tsshptApsLpcpltccFs.......lphG..+l+p....+sVGPHP...hh.aplsF.ssc.FspllsWLtlsRssLoVLlHP.T.G-...-LtDHT.cpAhWLGcplsLslshh	.........aHAHl.YF..........s.ssptphAptLpcpltccFs..............lplh.....phap......................+.VGPHP...th.aplsF....ssspa.ssllsWLslsR.GsL.oVLlHPsT....G-..............-htDHp.-pAhWlGcshsLshshh.......	0	36	83	130
+8716	PF08884	Flagellin_D3		Flagellin D3 domain	Bateman A	anon	Bateman A	Domain	This domain is found in the central portion bacterial flagellin FliC.  The domain contains a structural motif called a beta-folium fold [1].  Although no specific function is assigned to this domain its deletion leads to a reduction in filament stability [2].	21.40	21.40	21.40	21.40	21.10	20.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.34	0.72	-3.80	34	687	2009-01-15 18:05:59	2006-07-26 15:59:46	6	4	182	3	5	483	1	88.90	36	20.39	CHANGED	ushshouhs..ssslKsus.............ss...ssussuspsuclhaDs.sscYYlcVsuhst...su+sGaYcVsVss......sGpVohsssssp..tsstPs...usspVTpsQ	..............................s.T.shouhs..sssIKAus................Gu...ssuTssstsuslpFcs..ssKYYspVsGhss...suKsGhYEVsVss............sGpVohsussTp...sshPs...usoslTcsQ......................	0	1	1	3
+8717	PF08885	GSCFA		GSCFA family	Bateman A	anon	PSI2 target BIG_88	Domain	This family of proteins are functionally uncharacterised. They have been named GSCFA after a highly conserved N-terminal motif in the alignment. Distant similarity to the Pfam:PF00657 lipases suggests these proteins are likely to be enzymes.	25.00	25.00	29.90	29.50	22.50	19.80	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.72	0.70	-4.83	49	313	2012-10-02 11:02:24	2006-07-26 16:17:02	6	8	248	0	91	323	73	208.60	32	70.18	CHANGED	splhshGSCFApplGctLptttapsh..........................sssaGs.lYsstslhphlppuhspp..s....tpslatts...s+aash...shsshuhsotpclhpphspplp..........ps+ptlppushllhTLGhs.sappppssplhssC.tlsptpFscch.....holsEIhpshpthhshlpsl..NPpl+llhTVSPV.hht.......cshsuNphSKusLhsAsppl...sp................pp..s.cs..........tYFPSYEIlh.sphpchpaYssD...hhHssptuVsalhcpF	.....................p.plhhhGSCFApplupthttt..taph............................ss.aGh.lasPhul.phlpphhtt..........ttthh...t............thahs....tht..s..s.tthhtthpttht..........thtphh.phshhllTLGoshsah........pps.......utl...ls.NCpp.h.stp.Fpcph.....lolpEhhpshpthlphltth.......NP.ph+llhTVSPlRahp.......cshhtsphSKusLhhAhcplhp..........................t...p..ps.............hYFPuYEIlh..DcLRDYRFYtpD...hhHsst.ulpalhcpF..................	0	29	64	78
+8718	PF08886	GshA		Glutamate-cysteine ligase	Bateman A, Eberhardt R	anon	PSI2 target BIG_70	Family	This is a rare family of glutamate--cysteine ligases, EC:6.3.2.2, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria [1]. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase.  The structure of this family has been solved, and is similar to that of human glutathione synthetase and very different to gamma-glutamylcysteine synthetase from Escherichia coli.	25.00	25.00	77.70	77.60	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.23	0.70	-6.16	27	271	2009-09-11 17:05:15	2006-07-26 17:16:03	6	1	265	1	85	225	152	400.70	57	94.39	CHANGED	Ec+lLsppssIEcWFRtpWpcassPFYsSVDLRNuGFKLAPVDTNLFPuGFNNLsPphhPLslQAshuAlp+.hCP-A+plLlIPEsHTRNtFYLpNVstLppIhppAGhpVRlGSlsspIscsTslpLssGpplslEPLhR...sssRLul.csFsPCsILLNNDLSuGlPplLpsl.-QhllPPLHuGWssRRKSpHFpsYccVup-FucllsIDPWLINPhFspCsslsFtsppG.EsLAspVDslLs+IRcKYccYGIc-cPFVlVKADsGTYGMGlMoV+suc-lhsLNRKpRNKMuslK-Gh.VscVIlQEGVhThEphss..AVAEPVVYMlc+aVVGGFYRlHssRGtcENLNuPGhcFhPLuFppss.hPp.tt..Psss........................sNRFYhYGVlARLAhLAAuhElc	......Ep+ILsspssIEpWFRhpWpcHsPPFYsSVDLRNAGFKLAPVDsNLFPGGFNNLsP-hlPLAlQAA.uAl-+.hCP-AKslLlIPEs.....HTRNsFYLpNVttLspIh+pA.GhpVRlGSLsPpl...sEsTplpLssG.ppllLEPLhR...spcRlu..........L....c....s...FsPCsILLNNDLSAGlPsILcsl.cQhlLPPLHuGWssRRKSsHFusYccVApcFAKllsIDPWhINPYFspssGlDFpt...+pGc-sLAcuV-tVLpKIpcKYcEYGIs-+PaVlVKA.DAGTYGMGVMoV+susEltsLNRKpRs......KM.utsK-GLtVo-VIVQEGVYTaEpl......ss....AVAEPVVYMhDRaVlGGFYRVHsuRGtDENLNAPGMcFVPLuFpps.shPDsptc..PsAs.........................sNRFYhYGVlARLuLLAASlELE.............................	0	18	52	68
+8719	PF08887	GAD-like		GAD-like domain	Bateman A	anon	PSI2 target BIG_90	Domain	This domain is functionally uncharacterised, but it appears to be distantly related to the GAD domain Pfam:PF02938.	25.00	25.00	33.90	33.50	24.60	23.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.13	0.72	-3.98	14	185	2012-10-01 21:10:01	2006-07-26 17:18:58	6	2	130	0	28	187	5	100.20	28	50.71	CHANGED	DcsaphhLcpFG.shcpp.lssus.I..-+Y+s+LP-tLLcYWp-cGWsuau-GlFWhVNPp-YcsllssWltGs.hhst-sh+llARoAFG-lalWuEpsuhslplsshhs	...................................tp.hstp..I..c+Yc.st.LPspLlphWpcaGausahsGhhtllNPp-Yp....sllpphh.................ctc.shhslhpoAFGDlhhWtcppsh.........h................	0	5	12	19
+8720	PF08888	HopJ		HopJ type III effector protein	Bateman A	anon	PSI2 target BIG_86	Domain	Pathovars of Pseudomonas syringae interact with their plant hosts via the action of Hrp outer protein (Hop) effector proteins, injected into plant cells by the type III secretion system. The proteins in this family are called HopJ after the original member HopPmaJ [1].	21.30	21.30	21.50	22.80	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.43	0.72	-4.06	39	245	2009-01-15 18:05:59	2006-07-26 17:21:56	6	2	245	4	74	224	31	109.60	47	92.81	CHANGED	M.......slp-...hlppLpspspplpFs-ThslI-ppYcaoPsuFpNG.s...lhNpAGpNpGSCKlFuFAplpsLocppTLtsFGpaYR.-VLtsPcGsDHtNIRsFh.p...pGWsGlpF-spsL	..................lpshlspLps..pphpFsDslAhI-spYsasPsuFpNG....s.....hpNsAG.pNpGSCKlFuFApLpuLopppTLtsFG-aYR.sVLssP-GsDHtNIRsFh....p....pGWsGlpF-upsL....	2	22	45	63
+8721	PF08889	WbqC		WbqC-like protein family	Bateman A	anon	PSI2 target BIG_75	Family	This family of proteins are functionally uncharacterised. However it is found in an O-antigen gene cluster in E. coli [1] and other bacteria [2] suggesting a role in O-antigen production. Feng et al. suggest that wbnG may code for a glycine transferase [2].	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.34	0.70	-4.89	67	583	2009-01-15 18:05:59	2006-07-26 17:27:58	6	4	429	0	184	571	435	164.00	24	92.01	CHANGED	QPhahPalGYFphlspsDpFllhD-spa.p+pu..WhNRNpI.tssp..........G.phlTlPlp.......cspppp.pIp-hplssst..Wpc+phpslppsY.u+APaF.cphhshlcslap..pp.ppLschNhphlphls...chLuI..psplhhoSchph....stppsc..+llslspphuAspYlsu.uupshhp.p.....Ft.ttulplpahpht.h.tYsQ..hts...t.FlPslSIlDlLhssG.scshphlh	...............................................s.ahs.htaa.ph.lhth..-...hhl..pp.pa....+.ps..ahNRshI...hs.s.p..........u......hlolPl.........p.t...p.....hp-hplssp.........Wtph+hpsl.pt.sY.tpuPaF.p.h.s.ht.hht.....pphp.L.phN.phhphlh...ph...lt.l..p.p.h..opphth........tt.p.h..ht.tt.......................................................Y.Q.....t......F.stlSllDllh..u..pt.....h.................................	0	65	135	164
+8722	PF08890	XkdN		Phage XkdN-like protein	Bateman A	anon	PSI2 target BIG_83	Family	This family of proteins are functionally uncharacterised. They are found in prophage sequence in various bacteria.	22.30	22.30	22.30	24.80	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.68	0.71	-4.42	23	222	2009-01-15 18:05:59	2006-07-26 17:31:39	6	1	160	1	58	199	8	132.50	24	93.15	CHANGED	slp-...hlhpphhpp.ch..p..shhcRhss..G..l.aph+ulotcchscl+ccsTpppphht.......thppchDpscapupllhtuslpPs....hpsp-Lpcuass.ssc.Ell++h...L.hsGEhsslsspltElsGa.-ssh--...lEE...hK	...........................................................................hh.tphhtt.ph....p..hhh.cRhh....p..s..t.h.hpl+sloscchpclccpssphpt.ht...............thhpchDpp.pa..sp..llhpus..l.P-......................hcspELp.....c.u.....a.....s.....s.h.s.st.-ll+ch...L..hsGEhsslhstl.-lsGa...sp..p.......hp-...l.-E.hK.............	1	29	49	51
+8723	PF08891	YfcL		YfcL protein	Bateman A	anon	PSI2 target BIG_80	Domain	This family of proteins are functionally uncharacterised. THey are related to the short YfcL protein from E. coli.	25.00	25.00	25.70	25.30	22.60	22.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.76	0.72	-4.00	29	716	2009-01-15 18:05:59	2006-07-26 17:33:15	6	1	710	0	84	220	6	86.50	67	94.87	CHANGED	ltcaEppl.shIDshVppuoD.DELFAuGYLRGHluLulAphE.cspp.slcsLcs+lppSLppA..puELussDpsLVpshWppLttp	......IAEFESRILALIDs..MV-HASD..DELFASGYLRGHLTLAlAE......LEu....uDDH.Ss.pAV+ss....VSQSLEKAIuAGELSPRDQALVssMW-sLFpp....	0	8	27	55
+8724	PF08892	YqcI_YcgG		YqcI/YcgG family	Bateman A	anon	PSI2 target BIG_93	Family	This family of proteins are functionally uncharacterised. The family include YqcI and YcgG from B. subtilis. The alignment contains a conserved FPC motif at the N-terminus and CPF at the C-terminus.	20.80	20.80	21.20	20.80	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.49	0.70	-4.78	34	324	2009-01-15 18:05:59	2006-07-26 17:39:34	6	3	265	0	87	286	8	212.20	33	84.71	CHANGED	pptacpFpptlts.....ssFPClhuppuhppspL+hsFhs..p.tptpsspplspsLtcalct.cshs.phs...SLllhFcss......pphohppacchhWphLppLpptDs...psWPpclPsDPccspWpFsFuGcshFlhsssPua..tpRpSRphsh.hhlsFpPRhlF-cl..psssp.hup+h+ctIRpRlttaDshshpPpLutaGt.-spEW+QYhlp--sp.............scCPFptt	..............................t..tappFpphlh-......sFPChhuhpuhppsplRYsFls......ppshpclspslhpalchh+-p...s.hhp......uhhlFhcs.......cctol-tacchaWplLphL+cpDs...psWPppIPpDPcc.tWEFsFuGEPhFlhsssPua..ppR+oRp.h...us...hhlsFQPRtlF-s.l..puspt..tupph+phlRpRlppaDp.hPhHPsLupYGs.cppEW+QYhltD-.p..........h.u+CPFp..h....................................	0	22	54	70
+8725	PF08893	DUF1839		Domain of unknown function (DUF1839)	Bateman A	anon	PSI2 target BIG_68	Family	This family of proteins are functionally uncharacterised.	20.50	20.50	20.70	187.00	17.90	20.40	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.91	0.70	-5.46	13	104	2009-01-15 18:05:59	2006-07-26 17:48:32	5	1	96	0	42	97	5	312.40	50	90.29	CHANGED	hsshs..scshssHuLHus-tlWsETNCYlDLWIELLHuhGLsPhAALuFTVsQDFEGDQFTFFKaP.tDLEpLYGlsVpELAlYDsLEsHVtsQlsRG+lVLlEVDSYaLPDT+GsuY+ccHsKTTIAIDhlDs-AptluYFHssGYHphpGEDYcGlFph.sshppsss.hhPYsEhsKpstsshspssLhcAShsLLRpHLsRRPcpNPlstFRpsFstcl-plhsRs.saFHhYuFNsLRQLGANFELhu+aLcWLstpGpssPts..supustoIAoEAKVlQFRLARAVhR+KsDsspssLDsLEsAappslsuLApp	.......ht...cscpYcPHsLHusphlWppTNCYVDLWIEVLthhGLsPhAALsFTlo.DFEGDQFTFFKaPhEDLEpLYGIhVQEhAIa-sl-sHVEpQlAR...GpLhLVEVDuaaLPDTRGsoY+ppHsKTTIGIDsIDhptRpluYFHNuGYahh-GtDYDGLFtt.ssht........LhPYVEhAKRph.t.PL-.cptLs-sShsLLp+HLpRRPssNPIsAFRpthstcscslAsp.....PhsaFHtYoFNoLRQLGANFE.Lhu+YLcWLpssGtsuP.h......s........hssAscpIASEAhVlpFRLARAsuRuKp-cscusLDhlEpAassllsslut.h......	0	4	16	25
+8726	PF08894	DUF1838		Protein of unknown function (DUF1838)	Bateman A	anon	PSI2 target BIG_43	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	50.30	26.70	21.20	16.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.74	0.70	-5.15	9	37	2009-01-15 18:05:59	2006-07-26 17:54:37	6	2	34	0	19	34	76	224.60	36	82.65	CHANGED	cupslaahWpGplauhhsGE..cc+LFsl.GMsls+Chshs-ut....uachloRElhhYhDPpTG-lLcpWcNPWoscsVsVlH.............VANDPVp.............uhhptphsh..tG-phsashsl.LhYPNPLus-.Qht...sGshYpAsELFphhsspssLtss-sso.ssspluWsRlusWLPWMtMG.sR.GhLhapstGpKlsSh--Ls.hhpppIss+hPhYtpsPcphs-t.N.TSWhYF+phhc	........spplhahWpGclYuhhPGE...chLFthcGhNVu+sl.ps-ut.t..uachloRElhhYh......DPsTsElLcpWcss...t.ssVlH....................VhNDPss....................................................tthh.h.hshp..hGsphshshpl.LtYPsPLss.hQh.......sussYcAhELFpahsspssLt.sst.ss..ssphuWsRhusWLPWMthG.sRsGhLhapstGpKls.uas-lPthhps.IsschP.atpsPpphs-.sN.TSWhaF+ph.................	0	8	14	18
+8727	PF08895	DUF1840		Domain of unknown function (DUF1840)	Bateman A	anon	PSI2 target BIG_69	Domain	This family of proteins are functionally uncharacterised.	25.00	25.00	25.70	34.00	23.10	24.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.43	0.72	-4.01	41	231	2009-01-15 18:05:59	2006-07-26 18:01:24	6	2	210	0	91	204	18	103.90	36	96.15	CHANGED	M.LlTF+S+AsuDlhMht-lApplLpllG+.......ssss.GsIss--lPsAlppLcsAl....tuppstssssp...........pppccstctsluLuQRAhPLl-hL+tAtc..pss-VhW	......MllTF+S+AssDlsMhcDhAhhlLtllGK.......phs.cGlIos--lssAIs+L-sAlstt.ptptppssp.p........................tsctccppp-.sluLuQRAhPhlcML+pAtt..pss-VhW.....	0	15	47	72
+8728	PF08896	DUF1842		Domain of unknown function (DUF1842)	Bateman A	anon	PSI2 target BIG_72	Domain	This domain is found at the N-terminus of proteins that are functionally uncharacterised.	20.20	20.20	20.30	21.60	20.10	17.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.38	0.71	-4.35	17	105	2009-01-15 18:05:59	2006-07-26 18:20:34	5	2	61	0	24	64	0	115.10	44	60.12	CHANGED	sGLFsspYhl.....ussh.GAPsLpLsLLVsTsc+pVsGpApIoQusp.PPlshcucVWGpao.htl.ss....upspIlloLpGs......uGPtSs.ht.sF+LchlLssDWps...GsAsYcYh.psGpW	.............sGLFPVpahV.....uTsh.GAPsLhLsLlVsT.s-+oVsGhA..p..ITQ.uVs.PPLsF+AcVhGsas.htl.P.....ussplhloLpGss.......uGPhusthh.sFclchlLsssWpo...GsAoYRYa.psupW..........................	0	4	7	12
+8729	PF08897	DUF1841		Domain of unknown function (DUF1841)	Bateman A	anon	PSI2 target BIG_71	Domain	This family of proteins are functionally uncharacterised.	21.00	21.00	21.30	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.35	29	307	2009-01-15 18:05:59	2006-07-26 18:20:47	6	1	298	0	91	253	52	132.80	45	88.24	CHANGED	PoR-pl...RpFFh-sWpKtpsspsLosLEshAschItpHPEYHshLp.ssEstLspDYsPEtGpoNPFLHLShHLuIpEQlSIDQPsGIRssacpLst+.hss.H-ApHphMECLuEhlWpAQRsGssPDsssYlpslccp	.............................spc-V...R+FFhcsWpKphssp.LosLEthAschIttHPEYHt.Lp.sh-p.tlsp-ah......PEpG....coNP..FLHlShHLuIpEQluIDQP.GIRssa-pLsu+..sshH-ApHt..hMEsLuEtlWpAQRt.Gps.PDsssYlsplp+.h...	0	22	55	74
+8730	PF08898	DUF1843		Domain of unknown function (DUF1843)	Bateman A	anon	PSI2 target BIG_72	Domain	This domain is found at the C-terminus of a family of proteins that are functionally uncharacterised. The presumed domain is about 60 amino acid residues in length and is found independently in some proteins.	21.70	21.70	21.70	48.10	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.49	0.72	-3.93	15	126	2009-01-15 18:05:59	2006-07-26 18:24:54	5	3	42	0	24	71	0	53.00	56	33.94	CHANGED	PhYGVAIQpAhASGDLupMKuLsupA-pQLsptsplpsAlptLcsEIARLEtR	.shYGVAIQpAtASGDLu+MKoLustAcpQLuspspIAuALptLcsEIAKLEuR.	0	6	12	15
+8731	PF08899	DUF1844		Domain of unknown function (DUF1844)	Bateman A	anon	PSI2 target BIG_76	Domain	This family of proteins are functionally uncharacterised.	20.70	20.70	21.70	21.30	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.25	0.72	-4.06	18	82	2009-01-15 18:05:59	2006-07-26 18:29:23	6	1	81	0	54	80	123	74.50	40	62.58	CHANGED	plsFssFlhSLuoSAlhpLG-hPcPpoGphpc.sL.h.......A+poIDlLuMLpEKT+GNLos-Es+lL-slLh-LRh+Y	.........lsFssFlhSLsooAhspLGchssPp.oGphpp.sL.h........A+....poIDlLsMLpEKT+GNLss-Ep+lLcslLa-LRhpY..	0	33	46	53
+8732	PF08900	DUF1845		Domain of unknown function (DUF1845)	Bateman A	anon	PSI2 target BIG_78	Family	This family of proteins are functionally uncharacterised.	20.40	20.40	20.40	20.70	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.27	0.70	-5.05	25	252	2009-09-11 12:10:13	2006-07-26 18:32:17	6	2	206	0	69	241	11	209.90	34	82.41	CHANGED	ptphGuL..RSslslsLHTpaAhRLWp.GRptpcscp.............uIhGhssahuhhsplppu.uppDDPYADhallplEcpltpucpplpphspplcthhsp.lPsslslucstSlpPlplsLahsosLGapsVaLLscaDpLspplhpApHhuLlu+pctpchlcpGu+hlRplFulsQpY.......RasGloRcDht..tsNA+uppA...lc+hG.clPt-lLpGp+RSs..FuP..lsps	...........................................p..phGuL..+SshslsLHT+aA.RlWp.GR...tttcscs.......................sIlGhstalshhsphpps.utpDDPYuDhhhlplEcclppsp....pphpslt.ppl-phhus.lPsslslucshslp.....Plp..lslalsssLGapsVaLLssaDpLs++lhhApHhuLIs+sphc.p....hLscGu+hl....RplaulsppY.......+.hsGsoRsDht.....tpNutuptA......hcchG..clPp-lLpGp+RSp..FuP.sl...p...................................................	0	11	34	54
+8733	PF08901	DUF1847		Protein of unknown function (DUF1847)	Bateman A	anon	PSI2 target BIG_82	Family	This family of proteins are functionally uncharacterised. THey contain 4 N-terminal cysteines that may form a zinc binding domain.	25.00	25.00	28.40	28.20	21.60	20.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.01	0.71	-4.72	31	185	2009-01-15 18:05:59	2006-07-26 18:49:59	6	2	169	0	70	167	5	151.60	44	73.44	CHANGED	Csstp..tchlccshp.Yppc.pst+lupsAAplEuptY...........s+hTRlEElltFA++hGa++lGlAhClGLhpEu+lhscILcspGFElhSVhCKsGul-KsplGltcp...p.sshEuhCNPIhQAclLNctpT-LNlllGLCVGHDhLFhKaScAPlTTL	...................C.s.t....c.hppshphYpp-.pst+ltpsu.AplEuphY...........sc.hTRlEEllpFA++hGaKKIGlAhClGLhcEA+hhscIL.ctpGFE.lhSVhCKsGulsKsp.lGltcp....p.s.shEshCNPIhQAclLNctpT-LNlllGLCVGHDoLFhKYScAPlTTL...........	0	27	49	61
+8734	PF08902	DUF1848		Domain of unknown function (DUF1848)	Bateman A	anon	PSI2 target BIG_74	Family	This family of proteins are functionally uncharacterised. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of Pfam:PF04055.	24.80	24.80	24.90	29.80	23.90	24.70	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.78	0.70	-4.86	33	307	2009-01-15 18:05:59	2006-07-26 18:54:42	6	1	280	0	86	291	10	258.50	39	84.80	CHANGED	IISASRRTDIPAFYu-WFhsRl+cGaVhVpNPass+ploclsLpPcsVDulVFWTKNPtPhl...shLsElcshuasYYFpFTlTsYspp.lEPsl.....Pshpp.tlcsFppLSctlG.-RVlWRYDPlllosp..hsh......caHhcsFpplAstLs..GaTc+ClISFlDh..YpKscpshppls.....hh.psspc....chtplupphupI.....Apca.ulpLpoCu-chs.LsthG...ItpupCIDtpllccl.....hGpph...........................thtK.D+uQR..ptCGChcSpDIGsYs..TChHGClYCYA	.........................IlSsSRRTDIPAFYucWFhsRl.+..pGalhVpNPaN.pplo+lsLss....csVDslVFWTKNPtP.hl...spLppLpp....a.t.aYFpaTlTsYsc-.lEssl......Ps.hp.c.hlc.sFpcLSc.tl...G.tc..+llWRYDPIl.losp...hsh........paHhctFppluppLp..Ga.Tc.+sllSFlDh..YpKsppshtpht....................h.th.spc..........chhplupphscl.......Ap..p..a.....sl..plpoCuEphc....Ls.thG....lpputCIDtpll.ccl.....hGtp.l.........................................phtK..DpsQR..ptCuChtSh.DIGsYs..T.Ch+GChYCYA........................	0	43	70	78
+8735	PF08903	DUF1846		Domain of unknown function (DUF1846)	Bateman A	anon	PSI2 target BIG_73	Family	This family of proteins are functionally uncharacterised. Some members of the family are annotated as ATP-dependent peptidases. However, we can find no support for this annotation.	25.00	25.00	45.40	45.30	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.76	0.70	-6.04	22	660	2009-01-15 18:05:59	2006-07-26 19:20:06	6	3	644	4	66	448	23	479.30	62	99.14	CHANGED	+IGFDs-KYLchQScHIhERlspFssKLYLEFGGKLhDDaHAuRVLPGF-PDuKl+hLpcLKDpsEIlIsIsAsDIE+sKlRGDhGITYDpDVLRLIDsa+shGLhVsSVVITpYsu.QsuAshF+p+LE+hGIKVYhHYsItGYPo-lchIVSDEGYGKN-YIEToRPLVVVTAPGPGSGKhATCLSQLYHEaKRGlcAGYAKFETFPlWNlPLKHPVNlAYEAATADLsDVNMIDPFHLEAYGcTsVNYNRDVElFPVLpphhE+IhG.cSPY+SPTDMGVNMsG.sIsDD-Asp-AS+QEIIRRYapshs-htpstssccplp+lcLlMppsslospDRtVVssAhphA-cs............ssPusAlELsDG..pIlTG+TSsLhsuouAhlLNAlKcLAsIsc-lcLISPpsIEPIQpLKsphLGS+NsRLcs-ElLIALSloAsosssAphAhcpLspL+GC-sHoosILossDcpshRKLGlplTs-PhYpsp.pLYp	...........................K.uFDsEpYLphQp-HILERIsQ.F...D.GKLYLEFGGKhl-DaHAuRVLPGa-PDsKI+lLpcLK-QVElVIsINAusIE+sKsRGDLGIoYDp-VLRLIDpFp-hGlaVGSVVITQYsG.QPAA-sF+spLE+pGIcsYhHYsIcGYPoDh-+IlSsEGhGKNDYIcToRsLlVVTAPGPGSGKLATClSphYH-phpGl+uGYAKFETFPVWNLPL+HPVNLAYEAATADLcDVNMIDPFHLpsYGcTTVNYNRDIElFPVLKRhlE+IhG..cSPYtSPTDMGVNMVGFuIsDDEAshEASKQEIIRRYYpTllDaK.tpp.ls-ssVcKIELLMsclGlossDR+VslsARpKAEcT..............GuPAlAlELPsG..pIVTGKsS-LhGsoAAsLlNAlKphAsIs.cEl+LIpP-slcPIQsLKhcaLGS+NPR.LHosElLIALuIoAspNPsAtpAh-cLspL+Gs-AHSTlILocpDcslLRKLGIsVThDPhYphc+LY................	0	31	47	58
+8736	PF08904	DUF1849		Domain of unknown function (DUF1849)	Bateman A	anon	PSI2 target BIG_67	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	102.80	102.40	16.90	16.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.49	0.70	-5.05	26	192	2009-01-15 18:05:59	2006-07-26 19:20:35	6	1	186	0	65	145	128	251.00	40	87.83	CHANGED	usAtAAuussLssHRAlYDLsLtcopsptulsuhpGRhlY-Fs.GsuC-GYoscaRhVoplpss-sssploD.posoaEstcG+sa+FpscohsssphsppVcGsAcps..scshpVclcpPcscshsLs.tslFPTpHhhclIctAcsGcphhpsslFDGo-sucKshpTsslIGcstssssssssst.ts...........................................phsshstWPVTluYFs....ssss..-thPsYphSFcLaENGVoccLslDYuDFslsGpLucl-lhcsp	.......u.AtAuuuspLlPHRAlYDLoLscAsppoulsuhsGRMVYEFs.G..SAC-GYTosFRhVocls.s-pspcloDppoTTaE-uDG+sFRFhs+ohsscpls..ccVcGsAchp....sst.ssV+Lp+PcppolsLs.uo.FPTcHhtclIstAcuGp.phhpsslFDGS-cu-+lhsTosllG+tpss.ssscs.cs....s...........................................chuptphWPVTlAYF-......cppp....-thPlYchsF+LYcNGloRcLshDYGDFshpGcLscL-lhcp.s...	0	16	37	46
+8737	PF08905	DUF1850		Domain of unknown function (DUF1850)	Bateman A	anon	PSI2 target BIG_87	Domain	This family of proteins are functionally uncharacterised. Some members of this family appear to be misannotated as RocC an amino acid transporter from B. subtilis.	21.00	21.00	21.00	25.80	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.08	0.72	-4.17	50	249	2009-01-15 18:05:59	2006-07-26 19:21:19	6	2	241	0	113	252	29	90.80	25	58.67	CHANGED	pFoLpWsHSVE+spWpEsaplssss....LhLscschcuhGAGM.....csssssphcsGhahap.shs.shspls.ltsos..susapLshssp.....s.......hsLsp	.......FoltapHSVE+sthpEsaclssss....LhLtcs+hpuhGAGhs.......c.ss..sst.h.c.sG.hahhp..ht.sh..s..p..lp..ltsus..supaplshssp.....ph.l..t....................................	0	37	76	94
+8738	PF08906	DUF1851		Domain of unknown function (DUF1851)	Bateman A	anon	PSI2 target BIG_90	Domain	This domain is found at the C-terminus of a variety of proteins that are functionally uncharacterised.	27.40	27.40	27.40	27.70	26.30	27.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.40	0.72	-4.00	31	216	2009-01-15 18:05:59	2006-07-26 19:26:17	6	2	152	0	36	227	5	76.00	30	42.01	CHANGED	pphspplptFhhthpssph..s........hcs.....LFctAtccLG.LctDEhYGFsPALsLGGstslcsLpKlchhEHLhlLuQlss	....................................thp.Fht.hpspp.............hcc.ht..happAlc+h..G..LphsEhaGasPhLsLGGttcl-NLpKV+hhEHlhllsQl..s...........	0	11	20	28
+8739	PF08907	DUF1853		Domain of unknown function (DUF1853)	Bateman A	anon	PSI2 target BIG_96	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	27.30	27.20	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.85	0.70	-5.23	43	413	2012-10-11 20:44:44	2006-07-26 19:26:35	6	3	401	0	93	362	50	259.20	28	88.53	CHANGED	RDLuWhLtoPsLlssss.......................thhttaLpphDts..sssltphh................tsspR..LGhYhEpLhpahLp.....pssshcLlApNltlp.pps...pTLGELDaLl+s..sssphhHhElAlKaYLh..........ssssspt...........spWlGPNtcDpLcpKLs+lhp+QLsLuppstspthLsph......tssppplhhpGhLFhP..........hsssssssttlsssplpGhWhphc.-a.ths..........sttathLs+hsWLu..ssth..............sthhstpplpphlpphts............P.hlhth........tsthpEspRhFlV	........................................RpLsalltuPsLhpsts.................................tthhshLttL-t.s...stsLtcaht................ts..hR...LGhhhEpLhtahlp.....psP.thcl..lAtsl..tlp..ssG....pTlGplDFLlct.....tsp..p..h.HhElAlKaYLt..............................p..................ssahGPNspDpLstKhs+hhpHQL.Lopp..st...hhphh.th..............tshptphhlpGhLahs.................................stsshs...slsspphpGhWhptp.-.htths.................ttahhLs+.sWLsstph...................tts.h.tttth..................................................................................................................	0	16	47	75
+8740	PF08908	DUF1852		Domain of unknown function (DUF1852)	Bateman A	anon	PSI2 target BIG_94	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	134.20	134.10	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.84	0.70	-5.65	27	294	2009-01-15 18:05:59	2006-07-26 19:27:27	6	1	290	0	85	262	19	317.50	70	97.96	CHANGED	Msp-FsFoIKsIpFDEsYpPS-sTRlTTNFANLARGcsRQENLRNsLpMIDNRFNsLAaWDNPpuDRYoVELEIISV-hcI..cGsupsFPhIEILKTsIlD+KTscRI-GIVGNNFSSYVRDYDFSVLL.-HNKspspFSsP-sFG-LHGKLFKpFlsSssY+ppFsKPPVICLSVSosKTYHRTtNpHPVLGlEYpQs.....EhSLTDpYFpKMGLpVRYFMPsNSVAPLAFYF..hGDLLsDYTNLELISTISTMETFQKIYRPEIYNANSsAGphYQPSLcaQDaSLTpIVYDREERSQLAlcQGKFsEEHFIKPYpslLEQWSAs	....MspcFTFoIKolpFDENYpPS.-sTRITTNFANLARGpsRQENLRNsLpMIDNRFNuLAHWDNPpuDRYoVELEIISV-hsI........cusupsFPhIElLKTsIVD+KTscRIEGIVGNNFSSYVRDYDFSVLL.-HNKspspF...SlP-sFG-LHGpLFKpFlNSssYKtpFpKsPVICLSVSos+TY+RTpNpHPVLGlEYpQs.....-hSLT-pYFpKMGLpVRYFMPsNSVAPLAFYF..hGDLLsDYTNLELISTISTMETFQKIYRPEIYNANSsAGpsYQPsL+ppDaSLTpIVYDREERSpLAl-QGKFsEEpFIKPYpslLEQWSA............	0	11	29	59
+8741	PF08909	DUF1854		Domain of unknown function (DUF1854)	Bateman A	anon	PSI2 target BIG_97	Family	This potential domain is functionally uncharacterised. It is found at the C-terminus of a number of ATP transporter proteins suggesting this domain may be involved in ligand binding.	21.30	21.30	21.30	29.70	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.45	0.71	-4.56	22	103	2009-09-11 14:44:06	2006-07-26 19:28:22	6	3	102	0	52	97	16	131.80	42	45.30	CHANGED	ps+-GVsPVRAFPIuAPscGluLlstDG+ElhWl-cLspLssssRtLlEp-LAsREFhPpIp+IpsVSoauTPSsWpVpTDRGpsphVL+GEEDIRRLsups.LLIsDscGlpahItDhssLD+cSRKLL-RFL	..................................sacuVsPVRAFPIosPscGlSLh....s.s-G+ElhWI-cL.s.cLssssRpllEp-LAtREFhPpIp+IhsVSoauo.PSsW..pV-TDRGtsph....sL.+.G.E.EDIRRL.sups.LLIsDscGlpahI.DhpsLD+pSRKlL-RFL......	0	11	33	48
+8742	PF08910	Aida_N	DUF1855; Aida_N; Aida-C2;	Aida N-terminus	Mistry J, Sammut SJ, Coggill P, Zhang D, Eberhardt R	anon	pdb_1ug7	Family	This is the N-terminal domain of the axin interactor, dorsalization-associated protein family [1].	25.00	25.00	25.40	27.00	23.70	19.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.56	0.72	-3.81	8	75	2011-09-20 15:42:39	2006-08-01 13:23:48	5	4	53	1	50	59	0	93.80	62	33.31	CHANGED	pls+Wpuuhc+usDFDSWGQLlEAlDEYQhLu+pLpKpspu.tsspsFTE-QKKhluKlATCLcLRSpALQs...Tuup-uhoL--lKKLcslLKsllsss.ctFPlcVp	..........h.lp+WtuSh++usDFDSWGQLVEAlDEYQhLARH....LQKEAQu.pNsS-FT.E-QKKTIGKIATCLELRSAALQS...TQSQEEFKLEDLKKLEPILKN.IL.TYN.KEFPFDVQ..............	0	11	16	27
+8743	PF08911	NUP50		NUP50 (Nucleoporin 50 kDa)	Mistry J, Sammut SJ	anon	pdb_2c1m	Domain	Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha [1].	22.50	22.50	22.60	23.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.57	0.72	-3.60	35	204	2009-01-15 18:05:59	2006-08-01 13:53:58	6	5	157	7	130	216	0	72.10	35	13.50	CHANGED	uKRsAscpLo+DNa..DpE..--.s-EsGoFppASpElLpsRtItKs+RRt....ss...........ssssstushssFuuhshsss	....................uKRhApppLoccNa.......DpE.....-p..s--sGo.FphASp-VLpsRt.ItK..s+R+p.....s.......................pssssush.psFpuhths..s.....................................	0	42	67	105
+8744	PF08912	Rho_Binding		Rho Binding	Mistry J, Sammut SJ	anon	pdb_1s1c	Domain	Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions [1].	23.00	23.00	24.00	26.90	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.32	0.72	-3.67	22	184	2009-01-15 18:05:59	2006-08-01 13:56:02	6	18	68	4	94	144	0	67.40	56	5.32	CHANGED	LTpDluNLupEpEELNsKhKcupEchpphK-EE..hsslKAtFEKp...lpoER..TLKTQAVNKLAEIMNRK-	............................LTpDltpLspEKEELspKh...K.csp.E..c...hpthK-EE...hsslKApaEKp...LpoER..TLKTQ..AVNKLAEIMNRK-.	0	15	23	56
+8745	PF08913	VBS		Vinculin Binding Site	Mistry J, Sammut SJ	anon	pdb_2b0h	Domain	Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a secondary structure prediction of four amphipathic helices. The hydrophobic residues that define the VBS are themselves 'masked' and are buried in the core of a series of helical bundles that make up the talin rod [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.58	0.71	-3.88	22	278	2009-01-15 18:05:59	2006-08-01 13:58:23	5	29	85	5	132	225	1	116.70	43	7.10	CHANGED	oFVDYQTTMV+pAKAIAVTsQEMhTKSsTsP-ELGsLAsQhTsDYupLAtpup.AAssAEsEE..............................................................IGh+I+pRVQ-LGHGCssLVpKAGALQssPoDuYTK+ELIECARcVSEKVSpVLAALQAGNR	.......................................................oFlDYQTphV+tuKuIAhoApEMs..spSss.sPp..-LusLA.....sphopD.as.pLsp..puh.AAusApspE..............................................................luhpI..+spVp-LGpus.tLlptAuALpssPs.DshsK+..........-Lhcs.ARsVoEKV.utVLuALQuGs+.......................................	0	32	42	78
+8746	PF08914	Myb_DNA-bind_2		Rap1 Myb domain	Mistry J, Sammut SJ	anon	pdb_1fex	Domain	The Rap1 Myb domain adopts a canonical three-helix bundle tertiary structure, with the second and third helices forming a helix-turn-helix variant motif. The function of this domain is unclear: it may either interact with DNA via an adaptor protein or it may be only involved in protein-protein interactions [1].	27.10	27.10	27.30	27.20	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.22	0.72	-4.17	11	164	2012-10-04 14:01:12	2006-08-01 13:59:53	6	13	122	1	117	163	0	62.50	33	11.24	CHANGED	GRluaT-tEDsAILsYV+EpuRuP.uoVoGNALWKtMEKspLTpHSWQShKDRYLKHL+GQc+chL	......RhsaTspDDthlhpalt....p.......tcps..ss.h...s..G.Nplapph.......pcp....p.................pH..oWQSh+-RYlK+Lptp..................	0	38	61	86
+8747	PF08915	tRNA-Thr_ED		Archaea-specific editing domain of threonyl-tRNA synthetase	Mistry J, Sammut SJ	anon	pdb_1y2q	Domain	Archaea-specific editing domain of threonyl-tRNA synthetase, with marked structural similarity to D-amino acids deacylases found in eubacteria and eukaryotes. This domain can bind D-amino acids, and ensures high fidelity during translation. It is especially responsible for removing incorrectly attached serine from tRNA-Thr. The domain forms a fold that can be be defined as two layers of beta-sheets (a three-stranded sheet and a five-stranded sheet), with two alpha-helices located adjacent to the five-stranded sheet [1].	25.00	25.00	41.10	40.30	23.70	18.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.87	0.71	-4.20	35	141	2009-01-15 18:05:59	2006-08-01 14:01:24	6	3	129	15	97	144	14	135.50	45	25.44	CHANGED	MRlLhIHuDhhcYcs+cKs.chAE-..tssppuch--sLVsFsuVE+sD-ps.p.llcpAlc-Ihcsup+lcssp..lllYPYAHLSSsLAsPpsAhclLcplE...ptL..tppshcVhRAPFGWYKuFpIsCKGHPLSELSRoI	..........M+lLhIHu-hhcacs+cKs.c..h..sE-...tp.cpsch--sLVsFhuVE+sD-ps.ttllcpAlp-IhclusplKsps..lVlYPYAHLSSsLusPcsAlclLcplE...ptL..tppshcVhRAPFGWYKuFcloCKGHPLSELSRsI........	0	28	58	79
+8748	PF08916	Phe_ZIP		Phenylalanine zipper	Mistry J, Sammut SJ	anon	pdb_1q2h	Domain	The phenylalanine zipper consists of aromatic side chains from ten phenylalanine residues that are stacked within a hydrophobic core. This zipper mediates dimerisation of various proteins, such as APS, SH2-B and Lnk [1].	25.00	25.00	30.00	35.20	23.70	20.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.79	0.72	-3.65	7	161	2009-01-15 18:05:59	2006-08-01 14:02:27	6	4	64	3	89	161	0	58.10	48	9.67	CHANGED	.uWpEFCELHApsAAtDhA+pahhFlppN..Ppa.sPhust.FSt+Fs-hF.paFpsElpc	.....uWcEFCEhHApAAAhDF.A++Fphal.......ppp..Ppa..ss.P.s.uts...uFS++Fs-h..FhpaFptEVt......	0	12	20	44
+8749	PF08917	ecTbetaR2		Transforming growth factor beta receptor 2 ectodomain	Mistry J, Sammut SJ	anon	pdb_1ktz	Domain	The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9) [1].	25.00	25.00	25.00	36.20	21.50	22.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.02	0.71	-4.33	6	96	2009-01-15 18:05:59	2006-08-01 14:04:18	5	3	46	9	38	87	0	110.20	54	22.61	CHANGED	lspLCKFCDVptooCsGpsoCtSNCsITSICEpP-EVCVAIWR+s-cNlTlETlCHcPphpLYGhhL-DtNoopCVMKE+pssuGphahCSCssE.ECNDhLlFs....s.p.sppppll	..........spLCKFCDVc.ooCcspcoChSNCSITSICEcspEVCVAlWRKND-NlTlETlCHDPphshHGa...hL-DssSsKClMKEKKssGpsFFMCSCss-.ECNDhlIFs...phssts........h.............	0	1	7	18
+8750	PF08918	PhoQ_Sensor		PhoQ Sensor	Mistry J, Sammut SJ	anon	pdb_1yax	Domain	The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane [1].	20.30	20.30	20.30	20.50	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.98	0.71	-4.77	10	556	2009-01-15 18:05:59	2006-08-01 14:06:04	5	7	550	8	46	195	7	178.50	77	37.00	CHANGED	PFSLRsRFLlATAuVVLALSLuYGlVAlVGYSVSFDKToFRLLRGESNLFYSLAQWcNNKLoIslPPslDlNsPTLVLIYDEpGplLWRQRcVPcLEspIpsEWLc+sGaaELDTDscsSstlL.usNsphQcp...L+ch.-ssD-ssLTHSVAVNhYPATu+LPsLTIVVVDTIPQELQ+osl	....PLSLRVRFLLATAAVVLVLSLAYGMV.ALlG.YSVSFDKTTFR.LLRGESNLFYTLAKWENNKLpV..ELPE.N.l.DhQSPT.MT.LIYDEsGpLLWuQRDVPW.Lh.KhIQP-WLKoNGFHEIEuDVssTShLL.SsDHShQpQ...LpEV..RED.D...D.DAE.MTHSVAVNlYPATSRMPpLTIVVVDTIPlELKpSYM.....................	0	2	11	28
+8751	PF08919	F_actin_bind		F-actin binding	Mistry J, Sammut SJ	anon	pdb_1zzp	Domain	The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function [1].	22.20	22.20	24.30	28.80	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.48	0.72	-4.35	16	161	2009-01-15 18:05:59	2006-08-01 14:07:44	5	10	74	2	82	188	0	108.80	48	9.55	CHANGED	ssssploK-ulLElsphLcsulsphpss..s.h............hupahpLuDphppLashCssYs-s.hhsPHsKFpFRELloRLEsps+pLRs..suups......sssss+llscltsol+-IsslVQR	....................................h.uspIoKpslL-ss-.hL.......ssAIocsspp.....................hspaStll-sG+pLhsaCsuYVDs.I.QhRNKFAFREAlsKLEssLpELQl......ssAsAG.....sPusspshscLLSoV+EISDlVQR..	0	14	20	47
+8752	PF08920	SF3b1		Splicing factor 3B subunit 1	Mistry J, Sammut SJ	anon	pdb_2f9j	Domain	This family consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C-terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly [1].	25.10	25.10	25.90	25.40	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.17	0.71	-4.17	25	284	2012-10-02 12:52:19	2006-08-01 14:09:09	5	8	240	9	211	279	8	155.20	40	13.15	CHANGED	sssspp+.+RSRWD...pTP......sss.sssss................s.hppsch..sp...sP.....upTPhs....sp....................uhsTPhsspp..................hpspphhthphpp-h-pRNRP.....LoDEELDplL..PsEGYcILcPPssYtPlRss....tpKlhtsssshts....ssFhl..-sspu..........tppl	................................................................................................................................ss...ts+.++SRWD.......p.TPt............sst..s.............................tssp++SRW..Dp..........TP..........s...uuTPss.st.....................shATPsssph................................hssppht.shpapp-I-cRNRP.....LoDEELDsMh..P...E..GYKlLtPPsGYsPIRTP....ARKLhATP.s..Phsu........sGFhhQ.pt-ps....tth.....................................	0	83	121	175
+8753	PF08921	DUF1904		Domain of unknown function (DUF1904)	Mistry J, Sammut SJ	anon	pdb_1u9d	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.10	21.10	21.20	21.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.28	0.72	-4.00	20	267	2012-10-01 20:38:22	2006-08-01 14:12:29	6	2	254	2	45	195	7	103.30	40	97.80	CHANGED	MPHlRhRGlspctVpplScsLlc-Luslsssss-sFTlEalsSshapsGphspsashVEVLWFsRsp-spctlAphIsctlpph..sptpcVsVhFpsLssssYYcNGpH	..................MPHl+FRulptphlpplSpsLlpELuplhpsspc..sFThEhhs..opahhsG......ch...t.sa.PhVEVhWFs.RsQchp.DplApsITph.l+p...su.sclsVlFhsLspsuYY.sGpH......	0	18	26	35
+8754	PF08922	DUF1905		Domain of unknown function (DUF1905)	Mistry J, Sammut SJ	anon	pdb_2d9r	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.00	21.00	21.00	21.10	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.60	0.72	-4.41	48	396	2009-01-15 18:05:59	2006-08-01 14:14:49	6	7	306	1	165	375	65	81.40	27	63.68	CHANGED	FsAplh...psss.....sasalslPh-sucplstt..............GplpVpuslsGpsaps.SlhP...spG......salLslctslR+stGh.ssGDpVplpl	..............Fpu.lh.....tsts......shsa.ltlPh-htcphs.t..............G.plpVpuslss.h.sacs.olhs...hGss.........salLslcpslRcthuh.psGDtVpVpl.........	0	76	135	155
+8755	PF08923	MAPKK1_Int		Mitogen-activated protein kinase kinase 1 interacting	Mistry J, Sammut SJ	anon	pdb_1vet	Domain	Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer [1].	20.50	20.50	20.50	21.00	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.17	0.71	-4.47	7	141	2012-10-02 21:07:43	2006-08-01 14:16:48	5	4	114	5	84	146	2	113.10	45	83.01	CHANGED	-cl+caL..thhppV-Gl...puIhloDRDGVslh+lup-ss.ss.shcPuhlsTFshAs-QusKLsLGcN+oIIshYpsaQlVQhN.....tLPLllohlusossNsGhILuL-ppltsll....p-lppsl	..................................................cl++aL..chL.pV.-G.L....auIlloDRDGVPll+..Vu..s-su..P-.hA.lRPuFLoT.Fu.hAoD.Q.uS....KL.GLuKN.KoIIshYss..YQ.V.V.QhN....................+LPLlloFIA.os....sA.NTGh....I.luLEccLsslh....c-Lcpsh.....................................................................	0	35	42	62
+8756	PF08924	DUF1906		Domain of unknown function (DUF1906)	Mistry J, Sammut SJ	anon	pdb_1sfs	Domain	This domain is found in a set of uncharacterised hypothetical bacterial proteins.	26.90	26.90	27.00	28.80	25.20	26.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.68	0.71	-4.30	35	469	2009-01-15 18:05:59	2006-08-01 14:22:11	6	19	346	1	122	422	5	132.00	30	30.10	CHANGED	tustl.s.spApsl+.suGassV.sRYlosspssst....hsKslotsElcslhsuGLplhslYQhs........shts.usastu.ttGst-ApsAhphAtthGhspsssIYFuVD..DssssphsshllPYF+uhpsslut....s.....YcsGlYG	.........................h....l....tsppl+..suGatss.sRYlosppssst............hsKslohsEhcsltssGLplhsl...YQhG.......................ttps..upas...t..u..sGhtcAp.pAhphtt.s.hGhP..s....ussIYhulD..Ds.sptphs...spllP...Yh+uhpsslst....p.........a+sGlYu.....	0	35	83	110
+8757	PF08925	DUF1907		Domain of Unknown Function (DUF1907)	Mistry J, Sammut SJ	anon	pdb_1xcr	Domain	The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase [1].	25.00	25.00	25.40	29.40	19.60	24.50	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.86	0.70	-5.32	14	174	2009-01-15 18:05:59	2006-08-01 14:24:16	6	5	109	2	102	187	329	237.30	46	85.41	CHANGED	VlpuuLppNFtsVpVoVspCPDLpcsPFphsspGLsGpspls-VGGssaLlPhsphsKhYslhslu+c.hch....ssth..llGAGAGPa.hlGpNsEhhhNlphp................psspssNtSahuplsstsspsllcKhsp..scschuLLuNLahsEG.KPGpVL+lpA+pRTGpc.sFlsCIRpuLcp+YG-..+sVuLGGsFll+pGKA+hHlMP.-F...SpsPlpocEcl.NpWL+aa-MsAPLlslsVllSpDP..GLDLRlEHhHsFS.pHGc..GGHYHaDT...TP-pVEYcGYFssAEtlYRl	......................VlptuLppNFtplpVs.Vs-CPDLsptPFphsspGls..Gpspls-VGGsPaLlPhsp..pcK.hYslppls+c.lph....sssh..llGAGAG..Pa.hhG.NsEhh.slphp................ttp..ssNuSahuplp..s.....ts.t.tsllc+h.sp....pchphuLLuNLahS-G.p.P.G..c.Vlc.lpA+pRpG.t....salsshRpsLpp+Yss..csluhGGhFllppGcs+.HlMs.-F..............SpsPlp...oc-cl..spWL+aa-hp.APLlshsshVop.........Ds...shDLRlpHhHs.FS.pcsp....GGHYHhDT......TP-tVEY.GYF.sA-hlhRl......................................	0	31	40	80
+8758	PF08926	DUF1908		Domain of unknown function (DUF1908)	Mistry J, Sammut SJ	anon	pdb_1v9v	Domain	This domain is found in a set of hypothetical/structural eukaryotic proteins.	25.00	25.00	27.70	27.70	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.89	0.70	-5.64	6	371	2009-01-15 18:05:59	2006-08-01 14:26:40	6	10	86	1	177	290	0	235.00	62	18.97	CHANGED	PlDSPRNhSsuuslsFPF..ARp.hsp..RADGRRWSlASLPSSGYGTNsPSSolSSSsSSQERL....HQLPaQPTsD-L+FLuKHFRSoE......................................................................SssDED..................G+hSPhhRPRSRSL.SPGRSssoFDNEIlMMNHVYKERFPKATAQMEERLp-hIschs..PssoLsLADGVLGFIHHQllELARDCLcKSpsuLlTSRYFhELQEKLE+LLpEA+ERS-SEEVshIspLl+KLLlIISRPARLLECLEFDPEEFY+LLEAAEGQAKVsQGIKTDIPRYIIpQLGLsRDPlEEl	....................................P.DSPRNhS.ss.ssh.pFsF...s...................Rs....DG..RRWSLASLP..S.SGYGT.....N.TP...S..ST..V....S..S..S.sSSQE+L..........HQL.P.a.Q..P....T.sDE......L......+FLoKHFtooE....................................................................................................................................................S...lssEp...................s.pp.us...hR.PR.SRSL..SPGRos.s......shDp..EIlMMNH..VYKERFPKATAQMEERLp.-hlps.s............PsssL...s.LAD..GlLuFlHHQllElARDCLsKS.cpsLITSpYFhELQ-pLE+L.Lp-Aa..-RS.-StElsaltpLV+KlLIlIuRPARLLE.CL.E..FDPEEFYa.LLEAA..EGHAKEG.p.G...............I....Ks....DIP.+YIIsQLGLs+DPLtEh..........................	0	34	49	103
+8760	PF08928	DUF1910		Domain of unknown function (DUF1910)	Mistry J, Sammut SJ	anon	pdb_2fef	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.90	21.90	22.00	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.62	0.71	-4.07	16	185	2009-01-15 18:05:59	2006-08-01 14:30:54	5	3	113	0	30	177	5	119.60	23	41.43	CHANGED	RDsLpsEphhhctIc.pcctltch...pEcIhphcpctcpslpRh.........tshhshahhshchllAcYShGpsl-phps.a.pslsthEc..................hh-tc.stYh.hLWhlSLuILLch-cp.plppLspll	.....................................RD.ltscphhpchlph.pctIpc....ppplhphc...psppps.htp..........thhhshht..hp...h.c.hlhspYShGpslpplpp.a.phlp..hhcp............................shptp..shY.hphlahlSLulLLchccc..hpcLhphl................................	0	7	18	27
+8761	PF08929	DUF1911		Domain of unknown function (DUF1911)	Mistry J, Sammut SJ	anon	pdb_2fef	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	30.30	27.20	22.00	18.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.51	0.72	-3.37	20	220	2009-01-15 18:05:59	2006-08-01 15:05:44	5	3	139	3	37	214	5	107.20	32	37.40	CHANGED	pcs...pDhLlchLlsstshs....p.spchhappPYttLhpsl.....spst-ppsctLtpYl.cpWY+uhcshsW+sp............H+tstt.....sYaGYWuFEuAAlshlhulDDSuh+Dpsa.YPtDL	..............................................p....pDhLl-hllth.tt.th...p.spp..hhh.pPYtthh.chl.....ppspppt.ctLppYl.cpWYcu.ppch..s..W..+ss..................HKps.......sYhGYWuFEsAAlsKlhsl.D..DosL+sps.a.YPhDL.............	0	8	23	32
+8762	PF08930	DUF1912		Domain of unknown function (DUF1912)	Mistry J, Sammut SJ	anon	pdb_1z0p	Domain	This domain has no known function. It is found in various Streptococcal proteins.	25.00	25.00	94.70	94.60	23.10	16.30	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-10.05	0.72	-3.89	17	344	2009-09-11 13:53:27	2006-08-01 15:07:31	5	2	343	1	24	96	0	83.70	81	98.41	CHANGED	MSYEQEFLKDFE-WVpoQIplNQhAMsoupKVhEEDtDERAtDAaIRYESKLDAYcFL.GKFsNY+NGKuFHDlPDGLFGpRHY	MSYEQEFMKEFEAWVNTQIMIN-MAhKESQKVY.EEDQDERAKDAMIRYESRLDAYQFLLGKFENFKAGKGFHDLP-GLFGERNY.	0	2	5	14
+8763	PF08931	DUF1913		Domain of unknown function (DUF1913)	Mistry J, Sammut SJ	anon	pdb_1zru	Domain	This domain has no known function. It is found in a various putative receptor proteins from Lactococcus bacteriophages.	25.00	25.00	25.10	28.30	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.74	0.71	-4.40	5	97	2009-01-15 18:05:59	2006-08-01 15:09:40	5	2	97	66	0	69	0	145.80	80	54.39	CHANGED	MTIKNFTFFSPNGTEFPVGSNNDAKLYMMLTGMDYsTIRRKDWpoPlNTALNVQYsNTSIIAGGRYFELlNETVALNANSVNYIHANIDLTQTTsPVSLSAETSDNSNsVDINNuSGVLKVlIDIlTTNGhGVostcsPsQsToLD	.......MTIKNFTFFSPNGTEFPVGSNNDGKLYMMLTGMDYGTIRRKDWoSPL.NTALNVQYsNTSIIAGGRYFELL.NETVALKuNSVNYIHANIDLTQTAsPVSLSAETus...NSNsVDlNNsSGVLKVshDIhTTsGTGVhSsKs.spsohLD..............	0	0	0	0
+8764	PF08932	DUF1914		Domain of unknown function (DUF1914)	Mistry J, Sammut SJ	anon	pdb_1zru	Domain	This domain has no known function. It is found in a various putative receptor proteins from Lactococcus bacteriophages.	20.70	20.70	21.60	21.70	20.60	18.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.59	0.71	-4.05	9	84	2012-10-01 20:11:45	2006-08-01 15:11:48	5	3	82	140	3	68	0	114.10	37	30.57	CHANGED	lssNsls...hpGSlsl.hp..sh....sGsGLphphpKKs.-lVlh+ahGpl...sshssGhphu..WVctPap..Pshsp.SLlG+F.........sspusSFHIDlsPsGohpWWGsshupssl..RGsu.YFI	..........................lssNslo...lpGSlsVPspp.Th...psGsGLpLpLpKKNsDlVIl+ahGsl...ss.lppGhshuh...sWVchPap..PsssQ.SLlGHh.........sGpsssFHIDlsPsGolsWWGsslusssh..RGsuoYFI........	0	2	2	2
+8765	PF08933	DUF1864		Domain of unknown function (DUF1864)	Mistry J, Sammut SJ	anon	pdb_1zee	Domain	This domain has no known function. It is found in various hypothetical and conserved domain proteins.	19.70	19.70	20.30	19.70	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.27	0.70	-5.94	11	77	2012-10-01 19:57:26	2006-08-01 15:13:56	6	1	76	12	22	87	28	363.90	45	96.75	CHANGED	TpsstAFDcWIRscFl-lNocLEpLYapQsD+AsVsGlG-sLKttLcsEG+shIpsLLsEGNTDEGFDuAFDLLGNVGLYMAACRRHEITEPSRETsSPLhEASALAMHIGASIGVsPRFATAHLTTHNpAhsGlYKRFTsLsDE+LFlDYNT+GILAYKRAADALL+I.PLGloHPhoA-LLcsAcpALpcVl-SNptLFppLDs-RFF.CVRPYYKPaRVGuplYRGANAGDFAGINVIDLlLGLCtAN-PuYSQhLVDKFLYMMPEDQslLRDCMRRsSLMDcFLsutctspp..sWaQ-Nl+LFLpVCchHGpTAIQHHsQLVpKaIApPucphpQpHhup....lTASGPPLcVLLsuLcKLRD+RAAA+.RsDIpTRapDIp...tLKuoL	.............................................hss.Ahs-.lpuR..tLs.pL.tL....sc+tsV....GIss.L+phL.scGhs..........os.GFspAhshhtslGhahuuh+RH..t.pEPsc....ssPhlEsshLsh..utuhGlsPR.shhHlTsaN....Atssh.+paTsLsDEthhl.-.sphuh.hAhctAhsAhl..clps....lulpp..Phhuphhcshttt...LpchlES.shhap.....plssphFa.t.plRPY...............Y.......cPhR.......VGup.........sYh..GssAs-hs.l.VlDhlLhhs..pAscsuYpphh.shh.YhhPp.ptlhtchhtcPuLhDchLttt.p.us.sp....hpEslph........G.sAlp+h.pllh+FhA..sp.h-p..ta.ut.......shuSGs.h.shLusL.pLp...RAAsp.RtcItst..................................................................................................	0	3	6	15
+8766	PF08934	Rb_C		Rb C-terminal domain	Mistry J, Sammut SJ	anon	pdb_2aze	Domain	The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure [1].	20.70	20.70	20.70	21.00	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.96	0.71	-4.59	6	127	2009-01-15 18:05:59	2006-08-01 15:15:48	5	4	54	18	50	123	0	125.00	55	15.18	CHANGED	ILQYASsRPPTLSPIPHIPRSPYKhPNSPLRVPGSNNlYISPLKS.oR.....hSPshMTPRSRILVSIGESFGou-KFQKINQMVsSSDRuhKRohDuSuAPKPLKRLRFDlDGQDEADGSKs.uGEStLIQKLAEMoSTRSRMQEQKMKE-s-occc.p	...................csPsLSPIPHIP.p.SPh.p.ss.SPhRIstt.sIYISPhKs..........sothTPRSplL.hphutS.......ScchpcINpMlps.u-.R.shKRuhp.s.u.ss.pPhK+Lp...................................................p....................	0	4	6	18
+8767	PF08935	VP4_2	DUF1865;	Viral protein VP4 subunit	Mistry J, Sammut SJ	anon	pdb_2bai	Domain	This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice [1]. VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1 [2].	22.20	22.20	24.40	22.80	19.10	18.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-9.87	0.72	-3.38	12	688	2009-01-15 18:05:59	2006-08-01 15:18:15	5	18	80	15	0	699	0	81.60	66	4.62	CHANGED	GsGpSS.ssGspNpSGNoGsIINNaY.pQYQNShD..LusNshSstuspusssoosopoppotssshFSplus.........LLA	....GAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGG.......SNEGSTDTTSTHTsNT....QN......NDWFSKLAsSAFoGLFGALLA.....................	0	0	0	0
+8768	PF08936	CsoSCA		Carboxysome Shell Carbonic Anhydrase	Mistry J, Sammut SJ	anon	pdb_2fgy	Domain	Carboxysome Shell Carbonic Anhydrase is a bacterial carbonic anhydrase localised in the carboxysome, where it converts bicarbonate ions to carbon dioxide for use in carbon fixation. It contains three domains, these being: (1) an N-terminal domain composed primarily of four alpha-helices; (2) a catalytic domain containing a tightly bound zinc ion and (3) a C-terminal domain with weak structural similarity to the catalytic domain [1].	20.60	20.60	21.20	20.90	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	459	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.51	0.70	-6.13	22	80	2009-01-15 18:05:59	2006-08-01 15:21:33	5	1	77	2	31	84	273	428.30	46	83.35	CHANGED	HPLocpstNpcLpsYEppVKu+F-cIVPlLKclSulQH-.DFlppAQpLA+tcLGFsLPpplL-cAWVpsLDMRu......LaAaCVFpoapphS-pFFpsDPLpu....ppupth-sFLh-CGFHhlDlo.PCADGRLAHsluYsLRl.PauuVR.R+uHAGAhFDlEsoVs+Wl+TEHpRaREuhPNsAcpsTRYLKlslYHFSShDPsHpGCAAHGSsDthAApAuLpRLh-FRpAlENoFCCGASVDlLLIGlDTDTDAIRVHlPsssGclsLccalsstplYppThsLou-pA+tpItpsl........pstusus.p.GMhphIspLltNNlSQIDYVpphHsGpYs..DhGHAERFIGVG.GF+EVpLRNLoYFAHLDTVEEGAPDLDVGlKIFpGLNVu+sLPIPVllRFDYsu+VPGAR-RAlscCpRVpsAIpsRYs-LsspGLLashlTlR..DRsttssuEsVuushD	...................................................................HPLospttNppLhsYEpplKucF-pIVPsL+cluulQH-.DFhppAQplu+tcLGacLPpplL-cAWVpsLDMRA......LaAaClFpoachhu-pFapssPLpt....tpupthcpFLl-CGaHhlDlo.PCuDGRLutslsYsLRl.Phu.uVR.R+uaAGAhFDlEssVp+WscTEhcRaREuhPNsAptsTRYLKllsYHFSSsDPpHpGCAAHGSsDchAApAuhpRLh.cFRpAVENoFCCG.A.SVDlLLIGlDTDTDAIRVHlPsscG.chsLc+alsstpLYppThshss-pActpltpsl.........tutusus.p.GMhphlspLltNNlSQIDYVpphHsGtYs..DhGHAERFIGVG.GFcEVpLRNLsYFAHLDTVEEGAsDLDVGl.K.IFpuLNVu+sLPIPVll+F-Ysu+VPGuRERAltcCpRVpsAIpsRYscLsppGLLpstholR..D+stssshEhlut.........................	0	8	19	28
+8769	PF08937	DUF1863		MTH538 TIR-like domain (DUF1863)	Mistry J, Sammut SJ	anon	pdb_1eiw	Domain	This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein [1]. This domain is similar to  the TIR domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.55	0.71	-4.10	55	389	2012-10-02 18:56:14	2006-08-01 15:25:41	6	7	328	1	118	650	62	126.70	18	55.87	CHANGED	++lFlSacapsDs...php........pl+shhstp....tp.....t.hshs.hc.h.....pppscs....tI+chI.ccplpsossslVLlGppT.tp.........pcWVcaEIp.........................................................tuhc.........pspsllulplpshp..s............ssshsssshsh	...................................................hcsFlSapapcst........hhp..........tltphh..tp...................t..php...phc.h.....pppspt.....tlcphl.ccplpsossslVL.lGtpT.tp...........................ppW.l..pa..E.....I..p......................................................................................................................................................................t..uhc.....................tspsllulhlps....pph........................hh...............................................................................................................................................................................	0	36	74	99
+8770	PF08938	HBS1_N	DUF1916;	HBS1 N-terminus	Mistry J, Sammut SJ, Eberhardt R	anon	pdb_1ufz	Domain	This domain is found at the N-terminus of HBS1 proteins. It interacts with the ribosomal protein rpS3 at the mRNA entry site [1].	23.00	23.00	23.50	23.50	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.55	0.72	-3.86	47	250	2009-01-15 18:05:59	2006-08-01 15:33:01	5	9	187	2	144	233	1	100.30	25	15.27	CHANGED	D.-Dh..................................................psEs-....................tpcpLssE-pct.hppshspl+ptLsstss.h..s-pplp-ALWaaYaDl-KulshLhpchpsptsppp	............................................................................p...-h...................................................-.-sp.............................tps.tpcpLss..Dpsp.L.sslschRplLG-ss.....s-pplhEAlh+.......htFDlpKulshllpppptps.t..t..................	1	35	63	107
+8771	PF08939	DUF1917		Domain of unknown function (DUF1917)	Mistry J, Sammut SJ	anon	pdb_1ztp	Domain	This domain is found in various hypothetical and basophilic leukaemia proteins. It has no known function.	20.40	20.40	20.40	20.70	19.70	20.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.76	0.70	-4.63	20	148	2009-09-11 14:20:58	2006-08-01 15:35:33	5	5	120	6	107	159	2	202.60	27	72.09	CHANGED	phcphspsasstsaatptcsph.thh.....pst..............................t-tcspplhpstpos...................sEssssFLsRlsPuss.........Ia..........................t....chsptGpphLpthpphtthlptppsp.....t...uhsRtlsstRpth.pplhpLAhpstlhoGKWhlFlss-.cVDcsWptVAcATl.pGcLGhuAKVuT.......tscspspsRLIsVYTc......DasDcsDVhRVlc+LccL.Gllc.tt...IhYKsDsa..TYLs	............................................................................................................t................................................................................t...........ts........................................................tttlstaLt+h.Psps...........................................................s......thhp.up...p.ht.hh.hhtt...t................tshpt...spt....+....h.tplhpLAhppplhoGKWhla.hsss...clD.csWstlAcAss..pGc.....L..........s....A....KVus..................psptstpplICVYTp......DFpDct-Vh+lhp.tl.+ph...Glhp...............lhYKsDsaTah..................................................	0	33	62	83
+8772	PF08940	DUF1918		Domain of unknown function (DUF1918)	Mistry J, Sammut SJ	anon	pdb_2a7y	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	20.80	20.80	21.10	26.40	20.70	18.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.81	0.72	-4.63	18	199	2009-01-15 18:05:59	2006-08-01 15:37:26	6	7	132	1	67	133	1	57.00	55	62.72	CHANGED	M+ApsGDpLlV+Gpslsps-RcGEIlEV+G-cGuPPYlVRWpDpGHpohVaPG..PDAhV	...M+AcVGDhLVl+GsTlsptD+cGEIlEVRu.sDGuPPYlVRW...-sGH-uhVaPG..PDAlV...............	0	23	55	66
+8773	PF08941	USP8_interact		USP8 interacting	Mistry J, Sammut SJ	anon	pdb_2fzp	Domain	This domain interacts with the UBP deubiquitinating enzyme USP8.	25.00	25.00	29.50	32.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.27	0.71	-4.95	5	110	2009-01-15 18:05:59	2006-08-01 15:38:36	5	7	71	6	69	97	0	166.80	59	55.14	CHANGED	ELRolVQsQsp+lAELKpppsDpcpQluEQKRElpLlKtYlRAlRSoN..........PthRNlu-QlE+s..ElhcWssGLssARVTRWGGMISTPDssLQhlIRRuLsESGCPsHILN-LlENCHERRWPpGLuTLETRQtNRRhYEpYVsRRIP....GKQAVVVhuCENpHMuEslps-PGLVMIFAHGVE	................................cLRolVQpQQs+IuELccptuEpcpQluE.QKR-lQLLKsYMRAl.RSsN..........................PslpNlt-plEhs..EllcWssoLt.ARVTRWGGMISTPDslLQ..thIKRuLsESGCPspIls-LhENsHERpWPpGLuTLETRQhNRRhY-NYVs+RIP....GK......QAVVVhuC-NpHMs-Dhh.EPGLVM...IFAHGVE............................	0	17	21	43
+8774	PF08942	DUF1919		Domain of unknown function (DUF1919)	Mistry J, Sammut SJ	anon	pdb_2g6t	Domain	This domain has no known function. It is found in various hypothetical and putative bacterial proteins.	25.00	25.00	25.80	25.70	21.10	19.90	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.40	0.71	-4.96	15	177	2009-01-15 18:05:59	2006-08-01 15:41:26	5	2	148	2	17	139	4	178.80	38	78.08	CHANGED	l....+p.........hh++lh+phhspph+p+LpNp...shTIISsNChGuhIhccLuhpFpSPFlNLalpssDYlKhLcNhcaYhpp-..LsFhpsscs..............tYPlGpL....sDIcl+FhHYpS.cEA+sKWpcRpcRINaDNLalhhsD+Duso.c.lpcFDpLPaKNKVlFosK....sYsplcSshaI.uhEsps....pVushh...tth.s+cYhcpFDhlsWlN	...............................hhpph.t..hshh.hhcLpsp...sholISsNChGuhlh+pLs..apoPFVs.Lal.s.pDal+hLpNhcaY.hppp..LsFhpppps.................YPlGh.L......sDlcIHFhHYpS.pEAppKWpcRppR.l.......Nh......cNLahhhs.-cD...u...s...o.c.lpcFDpLPapNKllFsp+....sY..thc..S..thhlpu..Epps....plu.hh.........pp.hhp.FDhhsWhp................................................	0	6	11	15
+8775	PF08943	CsiD		CsiD	Mistry J, Sammut SJ	anon	pdb_1jr7	Domain	This family consists of various bacterial proteins pertaining to the non-haem Fe(II)-dependent oxygenase family. Exact function is unknown, but a putative role includes involvement in the control of utilisation of gamma-aminobutyric acid [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-12.02	0.70	-5.52	11	476	2012-10-10 13:59:34	2006-08-01 15:43:17	5	1	456	2	26	252	906	284.50	85	90.83	CHANGED	GaolssaspssRLhplTlscpsLcsFl-pspcasVQALEYKPFhRFclAchLcclsussLtshLssIlpDRcpGuFllsspGlss........ps--hVKhuTAluHLIG.sNaDAMoGpYYARFsVKssDNSDSYLRQAaRlM-LHsDGTaVcEtTDalLMMKhDEpNhtGG-ShLLHLDDWpDL-+FasHPLA+pshhasuPsSKNVsccVpHPVFFt.DspG+PsMpFIDQFspPpNh-EGhaLp-LS-SlEsSpsshsVplPlGshlVlNNaFWLHGRctFpts.sLpRELMRQRGtFs	..............................................................................GFTLhPSAQSPRLLELTFTEQTT+QFLEQVAEWPVQALEYKSFLRFRVGKILDDLCANQLQPLLLKTLLNRAEGALLINAVGIDDVA......QADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQP......HRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSL.........LLHLDD.W.E.H.L.Dc.aFRHPLARRPMRFA....A.PP....S.....K..N.V...SK.D.VFH...PV..FDVDQQ.G.R.PVM.RY....I....DQF.VQ........PK...DFEEGV.W..LS..ELSD...AI..E.......TSK..GI.......L.SV.......P.....VPVGKFLLINNLFWLHGRDRFT.P..HP.D...LRRELMRQRGYFA..............	1	5	8	18
+8776	PF08944	p47_phox_C		NADPH oxidase subunit p47Phox, C terminal domain	Mistry J, Sammut SJ	anon	pdb_1k4u	Domain	The C terminal domain of the phagocyte NADPH oxidase subunit p47Phox contains conserved PxxP motifs that allow binding to SH3 domains, with subsequent activation of the NADPH oxidase, and generation of superoxide, which plays a crucial role in host defense against microbial infection [1].	21.50	21.50	22.30	22.40	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.94	0.72	-3.78	12	85	2009-01-15 18:05:59	2006-08-01 15:48:52	6	11	38	2	33	74	0	58.90	39	14.82	CHANGED	.LQpR+pt.cshPpusuos......spsppsKstPslPPRPSs-LILcRCoEsT++Klo..pus	............................................hppR+p..tshsppssss....................spspcsKspPsVPPRPSs-LILpRCoEsT++Kls.....s.......	0	4	9	18
+8777	PF08945	Bclx_interact		Bcl-x interacting, BH3 domain	Mistry J, Sammut SJ	anon	pdb_1pq1	Domain	This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11 [1]. This domain is also known as the BH3 domain between residues 146 and 161.	25.00	25.00	62.30	62.20	21.80	20.60	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.05	0.72	-4.42	6	51	2009-09-10 23:22:43	2006-08-01 15:49:49	5	2	33	14	21	67	0	38.60	75	22.36	CHANGED	huup+ppputPsc.lpPElWIAQELRRIGDEFNu.a..P.RRu	......MAShRQSQAEPAD.MRPEIWIAQELRRIGDEFNA.Y.Ys.RR....	0	2	3	6
+8778	PF08946	Osmo_CC		Osmosensory transporter coiled coil	Mistry J, Sammut SJ	anon	pdb_1r48	Domain	The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function [1].	23.80	23.80	23.90	24.40	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.31	0.72	-3.93	10	544	2009-01-15 18:05:59	2006-08-01 15:51:13	5	3	540	2	42	183	0	46.10	82	9.30	CHANGED	SDlpEAKElLpEHHDNIEQKIEDIDpQIAELpcKRp+LlcQHP+Is	.....SDIQEAKEILsEHYDNIEQKIDDI.......D.......cEI.......A-....LQ.......A.......K.......RoRLVQQHPRID....	0	5	11	25
+8779	PF08947	BPS		BPS (Between PH and SH2) 	Mistry J, Sammut SJ	anon	pdb_2auh	Domain	The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor [1].	19.10	19.10	19.20	25.40	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.42	0.72	-4.34	4	191	2009-01-15 18:05:59	2006-08-01 15:55:43	5	6	54	1	97	163	0	47.70	66	9.83	CHANGED	RSsSENSLVAMDFSGct.GRVI-NPsEA.SsAlEEGpAWRK+oshRhuhh	............RSlSENSLVAMDFSGpt.GRVIENPsEA.SsAlEEG....pAW.R..K+us.Rhsh..........	0	11	18	45
+8780	PF08948	DUF1859		Domain of unknown function (DUF1859)	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	This domain has no known function. It is predominantly found in the N-terminus of bacteriophage spike proteins [1].	25.00	25.00	32.00	205.40	21.70	20.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.68	0.71	-4.39	2	14	2009-01-15 18:05:59	2006-08-03 15:07:56	5	2	6	1	0	7	0	123.50	66	53.00	CHANGED	Msspp.st.TVT..YNGs.shtGP.ulpuhh-.lAGppVhhDLph.hsTtthoGVQslYID.t-..Gshplsh.-TGQRIps.AGpQGYaPlLssshhKFlspthhsGK..hPh.FlNFsIA.GVW	Msspp.st.TVT..YNGs.shtGP.ulpuhh-.lAGppVhhDLph.hsTtthoGVQslYID.t-..Gshplsh.-TGQRIps.AGpQGYaPlLssshhKFlspthhsGK..hPh.FlNFsIA.GVW	0	0	0	0
+8781	PF08949	DUF1860		Domain of unknown function (DUF1860)	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	This domain has no known function. It is predominantly found in the C-terminus of bacteriophage spike proteins [1].	25.00	25.00	462.10	461.40	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.65	0.70	-4.74	2	7	2009-01-15 18:05:59	2006-08-03 15:09:31	5	1	6	6	0	7	0	219.00	96	64.41	CHANGED	PSGIKGDKGDPGtPGPAGGTVVVEDSGA.FGESLLDTsS-PGKILVKRISuGSGITlTDYGDclEIEAo.GGGGGGGGVTDALSLhYoTSoGGPASIAANALTDFDLSGALplNpVGTGhTKuAsGIQLAAGKSGLYQlTMTVKNNTVTTGNYLLRVKYGSs-aVsACPASoLTAGGTISLLIYCpVLGVPSLDVLKFSLCNDGAALSNYIINITAAKIN	PSGIKGDKGDPGtPGPAGGTVVVEDSGA.FGESLLDTTSEPGKILVKRISuGSGITVTDYGDEVEIEAS.GGGGGGGGVTDALSLMYSTSTGGPASIAANALTDFDLSGALTVNoVGTGLTKSAAGIQLAAGKSGLYQITMTVKNNTVTTGNYLLRVKYGSSDFVVACPASSLTAGGTISLLIYCsVLGVPSLDVLKFSLCNDGAALSNYIINITAAKIN	0	0	0	0
+8782	PF08950	DUF1861		Protein of unknown function (DUF1861)	Mistry J, Sammut SJ	anon	pdb_2b4w	Domain	This hypothetical protein, found in bacteria and in the eukaryote Leishmania, has no known function.	18.70	18.70	102.30	102.20	17.30	16.20	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.91	0.70	-5.61	12	151	2009-01-15 18:05:59	2006-08-03 15:10:58	5	1	107	1	25	116	5	292.00	48	95.12	CHANGED	htsFcts..cpha-sshLoFpGVsshDVYNhSsPFphpGchaIhGRVEcRDp.tpScVhhFpEstcspassV.sshsapLpDPFlo+lpsEhlFGGsclh....sssphhsahssFYRGp.hppLpaFsoGP-tMKDIRlVcLtDG+IGVFoRPpsc..ucshIGFshlssLsELTs-sIspA.hlc.thps-tWGGVNpsaLLosGplGsluHhuhh.Dpcsscc....YhshSFVhsPcTpphpph+lIuT+usFsssssKtPcLtDssFuuGllh+sDG+s-LYuGlGDsctt+lsI-.PFcGa	...........h...acpp..ppsapst+LpFsGV.s-+DVYNIoAPFp.tGphhIAGRVEuRDS.EtScVhFFpcp.pspas.VEssssat.LQDPFloplpGELIhGGVElhP+..sssshLsW+TsFYRGpslpsLppFhsGPsGMKDIRlscLtDG+IGVFTRPQG-h.....GGRGpIGashIsoL--LT.EsIpsA.LLcppFss-EWGGsNEsHLLssGpIGlLGHIAsFDppGsRH....YYshsFhhNs-opphpphKIIApRusFhPussKRPDLsDVlFoGGLlhpsDGsscLYuGluDu-Ap+IsIsDPFps......	2	12	20	22
+8783	PF08951	EntA_Immun		Enterocin A Immunity	Mistry J, Sammut SJ, Coggill P	anon	pdb_2bl8	Family	Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species [1]. To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc Pfam:PF10439). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin [2]. The C-terminal hair-pin recognises the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates [3]. These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, Pfam:PF01721. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids [4].	21.40	21.40	21.40	21.50	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.20	0.72	-3.83	62	1139	2009-01-15 18:05:59	2006-08-03 15:14:23	5	3	516	8	131	559	0	73.70	19	66.60	CHANGED	pcppph...hpplhpll...p..s.ptpp.plcplLhpstpclcpsps...h.hlhs+Lspslpthsh.p...phpLsps.pphhppl	............................pph...hphl.ppLh....pphchs.tsp..clpphLhpstpcLcpspp....phlhscLsptls.hhhhp...phphstplhshhh.l.....................	0	24	44	81
+8784	PF08952	DUF1866		Domain of unknown function (DUF1866) 	Mistry J, Sammut SJ	anon	pdb_1ufw	Domain	This domain, found in Synaptojanin, has no known function.	20.40	20.40	20.50	20.50	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.76	0.71	-4.66	6	189	2012-10-02 20:46:34	2006-08-03 15:35:34	6	6	73	2	80	187	1	141.10	47	10.92	CHANGED	Dl-lhEVDsppRpsVac-VIuspGPPDuTllVslpS.........s.sEsshFD-sLhspLlppLupaGEVsLVRFVp-pMWVTFtDGpSALssLslsuhpVhG+slpI+LKS.-Wl+tLE-El..psssplshu...ossSsLLu-ssshsss-a	............................-l-l.EV-sptRppVapEVhuhQGP.DuTVlVslpS...............oh.Eps.F.s-sLhsELhQphus.aG.p.ll.Ll.R.h.....sp.s...pM.....hVTFh-upSALsVLs.lsG..hcl.hGR.slpIp.Ko.D..Wl...KsLcEEh...p.phhslu...ossSsLLtEsh-hst......................................................	1	18	25	47
+8785	PF08953	DUF1899		Domain of unknown function (DUF1899)	Mistry J, Sammut SJ	anon	pdb_2akf	Domain	This set of domains is found in various eukaryotic proteins. Function is unknown.	20.70	20.70	20.70	20.80	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.05	0.72	-4.33	33	702	2009-01-15 18:05:59	2006-08-03 15:39:09	6	34	265	2	401	638	1	64.30	49	12.32	CHANGED	+hVRsSKaR...HVFGpssK+EpCY-sl+locssWDoshsulNPKalAVsh-uuGGGuFhVlPlsc.sG	.........phVRsSKFR............HVFGp.ss.Kp...-pCY-sl.+.l..S+s.s..W.D.o.sFCA..............VNP+FlAllhEuuGG.G..AFhVlPLpcoG........	0	119	174	282
+8786	PF08954	DUF1900		Domain of unknown function (DUF1900)	Mistry J, Sammut SJ	anon	pdb_2akf	Domain	This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function [1].	21.20	21.20	21.20	21.60	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.62	0.71	-4.64	64	952	2012-10-05 17:30:43	2006-08-03 15:41:35	6	51	276	2	567	880	1	128.00	42	25.62	CHANGED	Plss.hslDsusGlLhPaYDpDosllYLsGKGDusIRYaEl..ss-...t.hlphlspapSssPp+.........................Ghu.hhPKpulDVpcsElsRhh+lsss..s......lcPlSahVPR+.u.-hFQcDlYPsohus.cPuloAc-Wh.sGpssp..PhhlSl	......................lt..plDs.Ss.GlLhPaYDsDosllYLsGK......G..DusIRYaEl.........ss-..........tPalph.Lsp.a..p.S...t.c.PQ+.........................G.hu.hhP..KRu..l-VpcsE.ls.RhaKLpppp......lEPIuhhVPR+.........u....-hFQ-Dl.....YPsTsus.cP.u.ls.AcEWhsGpstt..PhhlSL.....................	0	177	252	404
+8787	PF08955	BofC_C	DUF1901;	BofC C-terminal domain	Mistry J, Sammut SJ, Bateman A	anon	pdb_2bw2	Domain	The C-terminal domain of the bacterial protein 'bypass of forespore C' contains a three-stranded beta-sheet and three alpha-helices. Its exact function is, as yet, unknown [1].	20.60	20.60	20.60	25.20	19.80	20.00	hmmbuild  --amino -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.37	0.72	-3.93	10	152	2009-01-15 18:05:59	2006-08-03 15:43:03	5	2	152	1	28	109	0	75.70	57	41.96	CHANGED	DDISPLsKsNGYhGlo-DGllSlFcG+Pcps.chIQSFFQIDlp+LES+hpcpLc+GIPl+TKpcaccVIEth+sY	..........DDISPLLKssGYFGVS--GlLpIF+GsP...cs-..psI+SFFQIDh+K....LE....Sa....c....+....s+LK+GIRI+SKEtFscsIE+hKpY....	0	9	18	20
+8788	PF08956	DUF1869		Domain of unknown function (DUF1869)	Mistry J, Sammut SJ	anon	pdb_1nei	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.30	21.30	21.50	21.30	20.20	20.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.87	0.72	-4.37	3	423	2009-01-15 18:05:59	2006-08-03 15:45:07	5	4	421	2	17	63	0	58.90	87	91.84	CHANGED	pscGpFLLTVTNNNNGVSVDK-FSoLAsL+DPplAAEoVKDLVNIVRGYDoDEETNVCGW	......MGKATYTVTVTNNSNGVSVDYETETPMTLLVPEVAAEVIKDLVNTVRSYDTENEHDVCGW.........	0	1	5	11
+8790	PF08958	DUF1871		Domain of unknown function (DUF1871)	Mistry J, Sammut SJ	anon	pdb_1u84	Domain	This set of hypothetical proteins is produced by prokaryotes pertaining to the Bacillus genus.	19.60	19.60	20.80	19.70	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.61	0.72	-3.91	7	175	2009-09-11 15:05:30	2006-08-03 15:49:52	5	2	170	1	22	97	0	78.70	47	89.54	CHANGED	ptMlclltpWDPFphGc-aY-TEsuDVlpAlash-DPcpLA+pIQpIYEhSFEphlPlEsCp+lAtpLLhIKpuuSCoh	......pMlcllcsWDP...Fp.....h....G....s......-....FYETEAuDVVsllpshD..Dsc..h..lAKcIQ+IYhhSFE..E...s....s..l..EcC.E..K..lAhcLLsIK-uuSCo.L....................	1	5	12	16
+8792	PF08960	DUF1874		Domain of unknown function (DUF1874)	Mistry J, Sammut SJ	anon	pdb_2blk	Domain	This domain is found in a set of hypothetical viral and bacterial proteins.	20.30	20.30	22.00	21.30	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.12	0.72	-4.29	12	35	2009-09-12 20:42:06	2006-08-03 15:52:21	5	3	35	6	11	38	1	104.10	29	78.08	CHANGED	Mt......lalhNuhhhsh..stpshhphccIshpEsKphl....psppFlSAIGHcuTAplloplhsssl.hNRlplphp.GD+AlshhLppRl.EGpVL.opcElc......cIuaphhlh	...................lYllNuhslsh...sp....shhchcclsh.cEscphl.....pspphlSA.IGHcuTApllspLL.s.........ssl.h..NR..lplchptGDcslshp.LppRl.EGpll.stcElp......clta.hh..h...................	0	7	9	9
+8793	PF08961	DUF1875		Domain of unknown function (DUF1875)	Mistry J, Sammut SJ	anon	pdb_2crb	Domain	The MIT domain, found in Nuclear receptor-binding factor 2, has no known function.	25.60	25.60	25.70	25.70	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.69	0.70	-5.06	3	73	2009-01-15 18:05:59	2006-08-03 15:53:06	5	3	39	1	40	59	0	206.80	62	81.58	CHANGED	MKLTESEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQuTE+DAAsHLQssH+PSsEDAEGQSP.LSQ.Y.PSTE+pLPElQGlFDRDPDTLLYLLQQKuEPuEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGshEKELDVDADFVEpSELWuLPsHuEoAsASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPL.....MELSEDILKGFMND	....................MKLTQSEQA+LSLELQRDSHMKQLLLIQERWKRApREERLKAQ...Qs...sD+-ssspLQsSt+PuuEDu-ups...P.l...s...pcaSPSsE+pLsElpGlFDRDPDTLLaLLQpKp.....E.....PsE.....PC.IGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLR+ENKQLKAEKARLlKGPhEKELDVDADFVEpSELWuLPP+S-oAsu.S..uoWQKFA.usoGKA.KDIPIPNLPPLDFPSPE......LPL.....hELSEDILKGhMs.................................................	0	2	5	20
+8794	PF08962	DUF1876		Domain of unknown function (DUF1876)	Mistry J, Sammut SJ	anon	pdb_2fgg	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	38.90	38.50	23.90	22.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.73	0.72	-4.20	6	190	2009-01-15 18:05:59	2006-08-03 15:54:17	6	2	118	1	53	125	0	86.30	47	88.10	CHANGED	HVhpsWpVDlpI-EHDp+TRAKARLR.WcG+ElVGVGLARLcPADcsVPcIGDELAlARALSDLApQLLsloocDIEAuTHQPu+sLa	.......hppWpl-l..I.-E+.....-.....t.....p.TRA+ARLc..h.....ss..p....pls..GsGlARhsPuDpsVPcIGDELAlARALuDLAppLlphuspDIEA..s.THpPsphl...........	0	16	44	50
+8795	PF08963	DUF1878		Protein of unknown function (DUF1878)	Mistry J, Sammut SJ	anon	pdb_1sed	Family	This domain is found in a set of hypothetical bacterial proteins.	20.90	20.90	20.90	22.50	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.50	0.71	-3.86	5	133	2009-01-15 18:05:59	2006-08-03 15:55:35	5	1	128	3	17	68	0	110.50	60	97.71	CHANGED	MpSlEcRlu+LEYYlcLLlcslDM-KYPFYuLlI+KsLoKEEu-Elt+lCcELu-EhEsQKAQGaVhFDcLLsLFAGQLsEKL-VHETIFALacQGLFpPLMsEFIoII+paD	...M.DVV+RLEQAEYYV-LLFKMI...DEEK..CPFYSLIIKKKARKKDIERILsLCEpLNEQYlsEKAEGLLLFDALLDQFEKALPHQLEVHETAEALtKQGLFpPLMNEFLsMIA+..c.....................................	0	1	7	10
+8796	PF08964	Crystall_3	DUF1881;	Beta/Gamma crystallin	Mistry J, Sammut SJ, Eberhardt R	anon	pdb_1yhp	Family	This family of beta/gamma crystallins includes the N-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 (Swiss:P54657), which mediates cell-cell adhesion through homophilic interactions [1].	26.70	26.70	26.70	27.00	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.86	0.72	-4.26	17	98	2012-10-01 23:14:22	2006-08-03 15:57:29	5	9	60	8	21	97	3	87.90	34	21.43	CHANGED	.sstshFappKNapGpuapYspussl....h.h.sspLND+FhSVclGstscVhhWcH.......pstshhhchssspsDlop.lsGLS+FpVhs	................tVCFYt-cNasG-SlChspGppl...........tsh.ssphND+lpSIpIPtuhpVTlYEcs....satGt.hshptshs...l.......................hs.p.s.h.....................	0	7	16	18
+8797	PF08965	DUF1870		Domain of unknown function (DUF1870)	Mistry J, Sammut SJ, Bateman A	anon	pdb_1s4k	Domain	This domain is found in a set of hypothetical bacterial proteins. It contains a helix-turn-helix domain so may be a DNA-binding protein.	23.60	23.60	24.10	24.40	22.90	23.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.66	0.71	-4.44	4	448	2012-10-04 14:01:12	2006-08-03 15:59:13	5	2	411	2	9	103	0	104.80	77	97.79	CHANGED	MNshELQALR+IhhhsIsEsAphIupsssSpTWQpWEsGclsIPs-l.tclhphpphRp+hlstllccls.......NtlGp.ThRaasDLpuFpphYs-usalcW+lYQSVsucLaAcsh-.cLs	......MNAYELQALRHIFAMTIDECATWIAQTG......sSESWRQWENG+CAIPDpVVEQLLAMRQQRK++lpAIl-KIN.......NRI..G...NNT.MRFFPDLTAFQpVYPDGNFIDWKIYQSVAAELYAHDLE.RLC........................................	0	2	4	6
+8798	PF08966	DUF1882		Domain of unknown function (DUF1882)	Mistry J, Sammut SJ	anon	pdb_2atz	Domain	This domain is found in a set of hypothetical bacterial proteins.	20.50	20.50	21.80	54.40	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.46	0.72	-4.01	10	188	2009-09-11 17:04:33	2006-08-03 16:02:25	6	1	188	1	17	76	0	72.60	66	40.34	CHANGED	MoshDLsLIKh.TsHYYIKRDsIlsKIca+GRpFasKFERIDAPLohsllpcHhc+cIslAHSLIs.+sDKVEN	.........hosMDhSLIKIIoDHYYI+RDpIspKITH+GRlFFDKFERVDAPLNhNlM+EHssKKIlVAHDLIo.KDNKVEN.....	0	5	14	17
+8799	PF08967	DUF1884		Domain of unknown function (DUF1884)	Mistry J, Sammut SJ	anon	pdb_1she	Domain	This domain is found in a set of hypothetical bacterial proteins. It shows similarity to the N-terminus of ATP-synthase.	28.60	28.60	28.80	72.50	27.90	28.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.75	0.72	-3.92	7	26	2009-01-15 18:05:59	2006-08-03 16:05:13	5	1	14	1	21	30	0	87.80	46	89.25	CHANGED	Mss..ps.hlcIls.lEptIsELK.-Ga-PDlILsG.Ehhcahsc..........shhph.pl+VhhlEELGsDAllsDSKhLG.l.tAuKRIpI.P	.........ps.hlclLshlEcphNELKh-GaEPDllLsG.Ehhcalsp..........chhchssLKlhll-ELGsDAVlsDSKhLG.lhtAuKRIpI....	0	2	2	11
+8800	PF08968	DUF1885		Domain of unknown function (DUF1885)	Mistry J, Sammut SJ	anon	pdb_1t6a	Domain	This domain is found in a set of hypothetical proteins produced by bacteria of the Bacillus genus.	25.00	25.00	29.60	118.30	20.60	19.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.66	0.71	-4.47	4	111	2009-09-11 06:05:25	2006-08-03 16:06:35	5	1	111	1	11	61	0	131.20	70	99.20	CHANGED	M.ppAaIKLV.pSsppoloI-DVKcLhchYKslTuKTG-QlsaAYspsAFPYEIh-pot...osLhLQSsc-RYssIhlGVs.........oEp-QoFIQloLPssATaGDKGKANEFs+FLAKKLpGELQLFNGRTMYFhpR	....MQHAFITLVPKSN.QQSVSIDDIKQLFHYYKTVTSKTGsQINYuYTNTAFPY-ILDTSs......TTLKLQSoH.DRYDSIYlGVG..........I.Ep....E...QS.....aIQlSLPPNATFGDKGKANEFCRFLAKKLEGELQLFNGRTMYFYKR.	0	3	6	7
+8801	PF08969	USP8_dimer	DUF1873;	USP8 dimerisation domain	Mistry J, Sammut SJ, Bateman A	anon	pdb_2a9u	Domain	This domain is predominantly found in the amino terminal region of Ubiquitin carboxyl-terminal hydrolase 8 (USP8). It forms a five helical bundle that dimerises [1].	20.90	20.90	20.90	21.00	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.35	0.71	-4.13	25	410	2009-01-15 18:05:59	2006-08-03 16:08:08	6	16	194	4	269	390	3	106.40	26	18.47	CHANGED	uphK.Lahu....sslccLpchsphh.pstpstshph.....hhpoApKlhcpA-cath-GD-EpAYlhYMKahslh.ptI+c+sDYpppcsph+phLGssphpchhhsp....hEcLppSLppRYcpt	.....................t..............plctLsphu.ps...h.ph...s...pshsh..+p........YhRousclh+tAphYtpEGshEpAYlLYh+ahsLhhcplspH.Da+..p.st...s..+p........th....p......p....hpch....h..h.c.........hEpL+...tpLht+Yp..............................................	0	71	118	194
+8802	PF08970	Sda		Sporulation inhibitor A	Mistry J, Sammut SJ	anon	pdb_1pv0	Domain	Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilised by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A) [1].	21.10	21.10	21.50	27.00	20.50	18.10	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.06	0.72	-4.47	18	164	2009-01-15 18:05:59	2006-08-03 16:19:17	5	1	141	4	36	93	1	45.20	58	91.48	CHANGED	Mcp...LSDELLhESYaKApELpLsPDFItLIcpEIhRRSLpcKlshSS	......Mcp...LSsELLhESYaKApEL+LssDFIhLIcpEIhRRSLccplshSS........	0	11	26	28
+8803	PF08971	GlgS		Glycogen synthesis protein	Mistry J, Sammut SJ	anon	pdb_1rrz	Domain	Members of this family are involved in glycogen synthesis in Enterobacteria. The structure of the polypeptide chain comprises a bundle of two parallel amphipathic helices, alpha-1 and alpha-3, and a short hydrophobic helix alpha-2 sandwiched between them [1].	24.20	24.20	24.40	24.20	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.28	0.72	-4.05	4	480	2009-09-13 10:19:12	2006-08-03 16:20:08	6	1	476	1	21	81	0	65.20	75	97.93	CHANGED	M.D+slYShsNFDFLApSFARMpuEGR.VDItAVTGNMsEuppsWFpcRYuaYpQQhhQtpthplEH	...........M.ccsl.SLNNFDFLARSFARMHAEGRPVDIhAVTGNMDEEHRTWFCARYAaYCQQhhQARELELEH..........	0	1	4	12
+8804	PF08972	DUF1902		Domain of unknown function (DUF1902)	Mistry J, Sammut SJ	anon	pdb_1wv8	Domain	Members of this family of prokaryotic proteins adopt a fold consisting of one alpha-helix and four beta-strands. Their function has not, as yet, been elucidated [1].	29.40	29.40	29.80	29.50	29.30	28.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.71	0.72	-4.41	8	55	2012-10-02 16:06:15	2006-08-03 16:21:41	6	1	52	1	31	65	2	53.10	39	65.57	CHANGED	lpIQAsWDsEAGVWVApSDDlPGLlTEA-TlEtLhcKlpsMlPDLLp-Nusspt	.............htlcshWDpEAsVWVApSsDl...PGLsTEAsTl-sLhpKlpshIs-LLphNt....t.......	0	7	16	21
+8805	PF08973	TM1506	DUF1893;	Domain of unknown function (DUF1893)	Mistry J, Sammut SJ, Iyer, LM	anon	pdb_1vk9	Domain	A member of the deaminase fold that binds an unknown ligand in  the crystal structure. The protein is ADP-ribosylated at a conserved aspartate [1]. Contextual analysis suggests that the domain  is likely to bind NAD or ADP ribose either to sense redox states or to function as a regulatory ADP ribosyltransferase [2].	20.50	20.50	20.80	29.90	18.30	20.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.56	0.71	-4.62	9	122	2009-01-15 18:05:59	2006-08-03 16:24:45	5	3	117	1	18	93	1	129.50	36	76.92	CHANGED	M-p.....hhclLccGGYShVlhp-pc.lpT.spRGltsLh-L...lpppsp.hcGAtlADKVlGKAAAhLhlhGGl+plYAclISpsAlclLcpssIcssYschVPaIhNRstoGhCPlEphsh-l-sscchaclIppFlpK	...........................p.....hhphLpptshohslhpc.pc..lho.ppRGltsLh-l....lspt.p....hcGup.lsDKVVGKAAAslhlhuGlppVaAsllSpsAhclLcptuIcVsapchVshI..s.RstsshCPhEshs.pl-ssEEhhthl.t...........	1	10	16	16
+8806	PF08974	DUF1877		Domain of unknown function (DUF1877)	Mistry J, Sammut SJ	anon	pdb_1ryl	Domain	This domain is found in a set of hypothetical bacterial proteins.	22.00	22.00	22.80	22.40	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.06	0.71	-4.59	16	510	2009-01-15 18:05:59	2006-08-03 16:27:53	5	2	476	2	63	275	3	158.20	50	98.00	CHANGED	MGMhspYhplsccclpcLh..st............stpshhphht-htpsp...........................phDl-KtWcsLHalLTGsss..........ppssPlu.slhGs..psht.-ss.s..sphhsssclpplsctLpslshcpLhppFshpphppsclYPs.h.p.pptcp-hh-plhphatcLpcFapcsucpspslLlhI	.....................................................................................................MGMIGhascIcsEclspLL....co.................................sccsLhD.sIcD...shsshc.........................................cLDIDKpWDhLHFsLTGoSAh.............-PscNDPLS+AVLGE...........cSL.....E..Du...l...DG..F...luLThspElAusl-+LEuLDcsELRKp......F......Sl...........K+Ls......Eh.E......I......YPG..l........shsEEh.E..up..l...F..us..Ihh.chEKLluhY++hL+pGspsLssI.............................	0	28	46	56
+8807	PF08975	2H-phosphodiest	DUF1868; 	Domain of unknown function (DUF1868)	Mistry J, Sammut SJ	anon	pdb_2fsq	Domain	This group of 2H-phosphodiesterases comprises a single family typified by the protein mlr3352 from M.loti. Members are also present in various alpha-proteobacteria, Synechocystis, Streptococcus and Chilo iridescent virus. The presence of a member of this predominantly bacterial group in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses (L.M.Iyer, E.V.Koonin and L.Aravind, unpublished observations and these appear to have been acquired from endo-symbiotic or parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for these proteins in regulating the viral tRNA metabolism. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family.	21.00	21.00	21.30	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.52	0.71	-4.34	13	265	2012-10-03 21:31:48	2006-08-03 16:30:44	5	1	258	1	37	106	81	117.50	61	51.47	CHANGED	KFspsGchhPhsGNTlVCHL-psusshp...slLshppphhshshAs+hsFhPsSShHMTlFpGlh-pcRpsshWPucLPlDsslschsshatpRLcsFsh..sssFphtl......ssspP.tulhL	...KFKENGEFNHFPGNTVVAN..LYTK..Q.DLME....VVDIIQSRYRELP..FI.DK.FT.L.TPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEIFPL......LDEEIHMRl......TEMGK.QNIL.V.........................................	1	5	17	22
+8808	PF08976	DUF1880		Domain of unknown function (DUF1880)	Mistry J, Sammut SJ	anon	pdb_1wlz	Domain	This domain is found predominantly in DJ binding protein. It has no known function.	21.30	21.30	22.30	21.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.54	0.71	-3.97	2	37	2009-01-15 18:05:59	2006-08-03 16:31:47	6	21	27	4	18	46	0	116.30	52	9.47	CHANGED	lQILTDEQFDRLWsEhPVNAKGRLKY.DFLS+hS.Epsso.PMAsGD...SshAQRGSSsP-hSpGTRSsL..Psp-.RsG.KSpSHPCTPs......GTPPLQNC-PIESRLRKpIQGCWR	..............................................................................................................lQlLTDEQFDRLWsEMPVNAKGRLKY.DFLS+FSoEcs.s....T...Ph..AsGD.......Ssh.AQ.RGSSV.P-lS...pusR...SAlSs.Psp-hRsG.KspS...H.P.CT.....Pustt..shsGoPPLQNC-PIES+LRK+IQGCWR......................................	0	3	3	6
+8809	PF08977	BOFC_N		Bypass of Forespore C, N terminal	Mistry J, Sammut SJ	anon	pdb_2bw2	Domain	The N-terminal domain of 'bypass of forespore C' is composed of a four-stranded beta-sheet covered by an alpha-helix. The beta-sheet has a beta2-beta1-beta4-beta3 topology, where strands beta1 and beta2 and strands beta3 and beta4 are connected by beta-turns, whereas strands beta2 and beta3 are joined by an alpha-helix that runs across one face of the beta-sheet. This domain is similar to the third immunoglobulin G-binding domain of protein G from Streptococcus, the latter belonging to a large and diverse group of cell surface-associated proteins that bind to immunoglobulins. It has been hypothesised that this domain may be a mediator of protein-protein interactions involved in proteolytic events at the cell surface [1].	25.00	25.00	26.80	26.40	24.70	20.60	hmmbuild  --amino -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.36	0.72	-4.15	10	128	2009-01-15 18:05:59	2006-08-03 16:36:58	5	2	128	1	18	85	0	50.80	61	29.42	CHANGED	lollLE+lYLDGEVSEEp+sETVhohEDFWupY+sWpLV-hc-splVFRKp	..VTILLERMYVDGEVSEEIhTEKVssLEcFLQQYKEWQLVDRDDsQIVLQKK..	0	3	10	12
+8810	PF08978	Reoviridae_Vp9		Reoviridae VP9	Mistry J, Sammut SJ	anon	pdb_1w9z	Domain	This domain is found in various VP9 viral outer-coat proteins. It has no known function.	19.00	19.00	28.90	21.30	17.60	16.50	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.84	0.70	-5.44	2	12	2009-01-15 18:05:59	2006-08-03 16:39:53	5	1	5	3	0	10	0	187.80	64	93.29	CHANGED	MlS-s.lRuhK+LuhpTpRssG-pThtLsSpVKLSKGEVEhlAVTKcEhh-tLtQCNL.plE.lsh-tTFNGslhRhuAahFlhpu.hlhhspslAVp.s.pYuTslAG.shphT.VhssphhhhtplstGs.usPaSspsuuLhIT.thsLhss.l.sGplhVLF.TSL.TThspoNSaAYShCslPhpcWD.phIKLTuETSCsSLsuMpsLsNSll.G-Rs.ssGLYVDI.GVTVoTSsS.uoLPlTslssshPlhFpAhs+.VEpVu.INhLYsLu	.......................................................................................................................................................................................................................WDFNMIKLTAETSCsSLTtMTNhlNoLV.GDRsRPVGLaVDIPGVTVTTSASluoLPITTIPAsTPLIFSAYhKQVEEVGlINTLYuLS...	2	0	0	0
+8811	PF08979	DUF1894		Domain of unknown function (DUF1894)	Mistry J, Sammut SJ	anon	pdb_1z9v	Domain	Members of this family have an important role in methanogenesis. They assume an alpha-beta globular structure consisting of six beta-strands and three alpha-helices forming the secondary structural topological arrangement of alpha1-beta1-alpha2-beta2-beta3-beta4-beta5-beta6-alpha3 [1].	25.00	25.00	26.20	59.70	23.60	16.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.05	0.72	-3.93	20	55	2009-01-15 18:05:59	2006-08-03 16:42:58	6	2	46	1	42	54	1	91.30	39	87.56	CHANGED	M.u.Cl-sh.....sYEILL+psoFKECc-aI+cpscElYclpPGaclh.GlhlIGhsPIPVGlcs..s.slIFPYTKPC..aGoFVl+l..pss.-Elc+lRc	...Mu.Cl-ph.....sYEILL+stoFKECp-aI+cshcElhclsPGhclh.GlhlIGlPPIPlGl-s...s.pllFPYTKPC..aGTaVl+l..pss.cElc+lR..............	0	10	27	35
+8812	PF08980	DUF1883		Domain of unknown function (DUF1883)	Mistry J, Sammut SJ	anon	pdb_2b1y	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.00	21.00	21.50	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.15	0.72	-4.45	10	161	2009-01-15 18:05:59	2006-08-03 16:45:37	5	3	155	1	48	116	3	87.50	35	79.80	CHANGED	M+Fs.Y-hcph+cG-llsloLs.pssNVRLMssuNFppF+NstcapY.hGGhsc+SPs+IsVPSoGaWhlllDh..sGp+Ghlsuol+...s..th..clhR	.........hpah.aphtphptuDlVVlcCS.ppCNI+LMsssNFppa+sGscasY.hG..Gshc+.PA+lsVPpoGaWslsIDo..tupp...hphohp.............hh...............	0	9	16	33
+8814	PF08982	DUF1857		Domain of unknown function (DUF1857)	Mistry J, Sammut SJ	anon	pdb_2ffs	Domain	This domain has no known function. It is found in various hypothetical bacterial and fungal proteins.	21.30	21.30	24.70	24.50	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.68	0.71	-4.61	17	171	2012-10-02 19:24:03	2006-08-03 16:54:50	6	4	160	2	79	146	10	151.00	33	88.30	CHANGED	papahl.lNsPss.thssLTRpQlWpGLlh+ucpPp.Fls.ul.-pCpllpcs........sstltRcLpa.........GsthlcDpVpht..pplca.....tptsGuolshhI-.......-sssusLaLRFhYchphs.hpssut-.cth..p-hh+pua+tushcTl+hIRphstsGp	...............pFEHLlplNssss..thssLTRsQlWpGLVhRAcpPphFV..GL.-sCtlhpcs.............sstlcR-Lpa................Gps.sl+DcVThpssp.pVcaph..sssttsGu...oLohsIE.......E.s.-..st.pLFlRFtYcTsls....h.pss.ot-tpph..pphlKpAY+puDl-Tl.chIR-hstt..............................	0	10	41	64
+8815	PF08983	DUF1856		Domain of unknown function (DUF1856)	Mistry J, Sammut SJ	anon	pdb_1ytv	Domain	This domain has no known function. It is found in the C-terminal segment of various vasopressin receptors.	25.00	25.00	30.70	29.60	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.47	0.72	-3.87	9	110	2009-09-11 07:47:04	2006-08-03 16:57:04	5	1	65	0	32	102	0	46.40	58	11.36	CHANGED	shpKEDSDSSh..RRpT.hT+h.ssRoPosuh......ssWK...sSPKSScSl+hl.hpp	.cFsK-DSDShS..RRQT.ao...NNR.SPTNSo......GhWK...-SPKSS+Sl+FlPlsT.............	0	1	4	14
+8816	PF08984	DUF1858		Domain of unknown function (DUF1858)	Mistry J, Sammut SJ	anon	pdb_2fi0	Domain	This domain has no known function. It is found in various hypothetical bacterial proteins.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.71	0.72	-4.31	33	1114	2009-01-15 18:05:59	2006-08-03 16:58:53	6	29	835	3	232	793	11	56.80	29	33.48	CHANGED	Ishshslt-llcpaP-sl-lhhph..GFpplssPshhpohu+hhTLcpuuphtslslsplh	...............Ishshslu-llcpa....P....-..ll.-lLhch...GhcsLusPh.....u.phhoLcpuuphcGlsh-clh..........	0	110	183	204
+8817	PF08985	DUF1888		Domain of unknown function (DUF1888)	Mistry J, Sammut SJ	anon	pdb_1ai4	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	31.70	31.40	23.10	22.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.54	0.71	-4.44	4	33	2009-09-11 00:41:11	2006-08-03 17:02:49	6	1	32	21	10	34	5	121.90	49	94.95	CHANGED	Mpss.spspaIpVTVTLE.NGEPVFsYTsApGt.p.GDVslTpuuT.ITY.LpDQTGKGLKFVGAuFhTPFDplIDAVplSoDGpLlpLsDLDcssGsTpFQFVLoNouNTLhlLSPDPplIN+sp	........M.ss.t.upalpVsVTLE.NGEPV.F.YTcss.Gc..ts.sGDVTlTpuuT.lTYhL..sDpT.G.K.GLKFVGsGFl.....TPFDp....ll....D..AVTlSoD..GhLlQLVDhDcoPGoTKFQFVhoNosNTLllLSPDPplIN+s.p..	0	2	3	5
+8818	PF08986	DUF1889		Domain of unknown function (DUF1889)	Mistry J, Sammut SJ	anon	pdb_2es9	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	53.20	53.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.73	0.71	-3.92	2	354	2009-01-15 18:05:59	2006-08-03 17:04:34	5	1	350	2	10	76	1	99.00	87	99.77	CHANGED	MQIKVIYSLIDNMVNFKDKNMPAVIDKALDFIGAMDVSAPTPSSMNESTAKGIFKYLKELGVPASAADITsRAD.EGWNPGFTEKMVGWAKKMEoGER.VIKNPEYFSTYMQEELKALV	...................................MPAVIDKALDFIGAMDVSAPTPSSMNESTAKGIFKYLKELGVPASAADITARADQEGWNPGFTEKMVGWAKKMEoGERsVIKNPEYFSTYMQEELKALV.......	0	1	1	6
+8819	PF08987	DUF1892		Protein of unknown function (DUF1892)	Mistry J, Sammut SJ	anon	pdb_1n6z	Family	Members of this family, that are synthesised by Saccharomycetes, adopt a structure consisting of a four-stranded beta-sheet, with strand order beta2-beta1-beta4-beta3, and two alpha-helices, with an overall topology of beta-beta-alpha-beta-beta-alpha. They have no known function [1].	19.90	19.90	21.10	60.70	19.10	17.50	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.58	0.71	-4.07	9	44	2009-01-15 18:05:59	2006-08-03 17:08:24	5	2	42	1	28	38	0	110.00	45	85.71	CHANGED	Must..............-NshRhlllL-cs....ppcpsptDc+...........hlDE......VpphDplNpaFDKFDEcIsIPNEGHIKYEluSDGLlVlIlD.KEl.-cVlshVcsasppsp.cppctpD	................h.ut..............sNsaRhllLLE-...................cp..c.....s...c.-E+................p-FlDE.....tlsphDplNpWFDKFDpcICIPNEGHIKYEluSDGLlVlllD.+El.--VlchVccaVccs.........p..............	0	3	14	25
+8820	PF08988	DUF1895		Protein of unknown function (DUF1895)	Mistry J, Sammut SJ	anon	pdb_1zw0	Family	The YscE protein, produced by the pathogen Yersinia, assumes a secondary structure composed of two anti-parallel alpha-helices separated by a flexible loop. The function of this protein is, as yet, unknown [1].	21.80	21.80	22.30	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.19	0.72	-3.94	5	99	2009-01-15 18:05:59	2006-08-03 17:10:32	5	1	94	16	12	42	2	66.40	37	86.26	CHANGED	MTsLEppLpu.ussppVcsIpp+LpQAQucVKRQLcpGGsPQQYQlWp+Qu-AlpAAlsIIcTlEucpK	.......MTpLEphLps..sspps+uIphpLctAhspl++phs+GssPpQYQ.hppphcAlEuAhsIIphht............	0	4	6	7
+8821	PF08989	DUF1896		Domain of unknown function (DUF1896)	Mistry J, Sammut SJ	anon	pdb_2apl	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	26.30	26.10	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.80	0.71	-4.32	7	270	2009-01-15 18:05:59	2006-08-03 17:11:53	5	1	103	1	19	217	4	140.40	50	90.90	CHANGED	hsppppELSYa+LtLLsYL+EsHPchAGDpsFIppRu-pAAcsYpcAltpGhshstAtphAptlLhpGLHFS+YDslhpVl.sEFtsEVPptptcshsLpLL..P.scsVFs+YslsDD.FphSPpYcpLYsELTGsIhhhlEc.Gl	........................h.ppspp-hSYatLpL.sYLp-p+PEphsD......psFIptRADpAhpsYpcAhtpGastspApphAp-lLapGLHFS+YDTLhpVlENEFpcE....lPsshsEphs.hLL....hlpsVFs+Y-..LoDD.FAhos-Y-pLYTELTGslVLhIEppGl..........	0	8	15	19
+8822	PF08990	Docking		Erythronolide synthase docking	Mistry J, Sammut SJ	anon	pdb_1pzr	Domain	The N terminal docking domain found in modular polyketide synthase assumes an alpha-helical structure, wherein two alpha-helices are connected by a short loop. Two such N-terminal domains dimerise to form amphipathic parallel alpha-helical coiled coils: dimerisation is essential for protein function [1].	20.90	20.90	21.00	21.30	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-7.08	0.72	-4.70	141	653	2009-01-15 18:05:59	2006-08-03 17:16:00	6	165	190	6	148	643	1	26.80	48	0.94	CHANGED	MssE-KLh-YLKRlTuDL+psRpR.L+-	.....ss--KLh-YLKRlTuDL+coRpRLpE....	1	24	106	140
+8823	PF08991	DUF1903		Domain of unknown function (DUF1903)	Mistry J, Sammut SJ	anon	pdb_1hp8	Domain	Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown [1].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.78	0.72	-3.82	7	194	2012-10-02 15:44:21	2006-08-04 08:57:27	5	3	149	3	132	223	0	59.70	30	66.44	CHANGED	psPCptpACAIQsCLptstYsEu+CtslI--LhpCCtpa......cu+SlCCst.pl.....lphc...hpptpK	...........sPCptpAC...t.lQ.pCLp...cNsY.....scs+CpphlptlpcCCppa.t.......ptpo..Cs..t......................t.............................	0	33	70	107
+8824	PF08992	QH-AmDH_gamma		Quinohemoprotein amine dehydrogenase, gamma subunit	Mistry J, Sammut SJ	anon	pdb_1jmx	Domain	Members of this family contain a cross-linked, proteinous quinone cofactor, cysteine tryptophylquinone, which is required for catalysis of the oxidative deamination of a wide range of aliphatic and aromatic amines. The domain assumes a globular secondary structure, with two short alpha-helices having many turns and bends [1].	25.00	25.00	92.90	92.20	19.80	18.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.98	0.72	-4.22	9	37	2009-01-15 18:05:59	2006-08-04 08:59:52	6	1	32	4	14	41	1	77.80	67	75.10	CHANGED	suVVGCToThDPGWEVDuFGGVuuLCQPMEADLYGCuDPCWWPAQVPDThsoYPcWupcAsssspDWRpLsoVFPpsK	..............suVsGCTsThDPGWEVDuFG.GVuSLCQPMEADLYGCSDPCWWPAQVPDhhsoY.DWsspAssuscDWRpLsoVFPcs....	0	2	9	11
+8825	PF08993	T4_Gp59_N	T4-helicase_N;	T4 gene Gp59 loader of gp41 DNA helicase	Mistry J, Sammut SJ	anon	pdb_1c1k	Domain	Bacteriophage T4 gene-59 helicase assembly protein is required for recombination-dependent DNA replication, which is the predominant mode of DNA replication in the late stage of T4 infection. T4 gene-59 helicase assembly protein accelerates the loading of the T4 gene-41 helicase during DNA synthesis by the T4 replication system in vitro. T4 gene-59 helicase assembly protein binds to both T4 gene-41 helicase and T4 gene-32 single-stranded DNA binding protein, and to single and double-stranded DNA. The structure of T4 gene-59 helicase assembly protein reveals a novel alpha-helical bundle fold with two domains of similar size, this being the N-terminal domain that consists of six alpha-helices linked by loop segments and short turns. The surface of the domain contains large regions of exposed hydrophobic residues and clusters of acidic and basic residues. This domain has structural similarity to members of the high-mobility-group (HMG) family of DNA minor groove binding proteins including rat HMG1A and lymphoid enhancer-binding factor, and is required for binding of the helicase to the DNA minor groove [1].	21.10	21.10	21.80	22.20	20.00	21.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.05	0.72	-3.98	8	64	2009-01-15 18:05:59	2006-08-04 09:01:32	5	2	62	1	0	53	451	91.20	41	44.10	CHANGED	lsuhuVY+LYLshKsHhsG.KYDhlKYpWp.hRso-sAFpKR+DKYFFcKLAcKaoLpElhtlhluNhlANscu...WlG-IsssDAhsFYtcalG+hc	...puhsVYplYLhlKpHFss.+YDhlKYshp.h+sS.-suapKR+D+YFFpKLucKaph+..E.Lt.hFluNhVsNscu...WlG-lsstDAhshYp-als+h.p............	0	0	0	0
+8826	PF08994	T4_Gp59_C	T4-helicase_C;	T4 gene Gp59 loader of gp41 DNA helicase C-term	Mistry J, Sammut SJ	anon	pdb_1c1k	Domain	Bacteriophage T4 gene-59 helicase assembly protein is required for recombination-dependent DNA replication, which is the predominant mode of DNA replication in the late stage of T4 infection. T4 gene-59 helicase assembly protein accelerates the loading of the T4 gene-41 helicase during DNA synthesis by the T4 replication system in vitro.  T4 gene-59 helicase assembly protein binds to both T4 gene-41 helicase and T4 gene-32 single-stranded DNA binding protein, and to single and double-stranded DNA. The structure of T4 gene-59 helicase assembly protein reveals a novel alpha-helical bundle fold with two domains of similar size, this being the C-terminal domain that consists of seven alpha-helices with short intervening loops and turns. The surface of the domain contains large regions of exposed hydrophobic residues and clusters of acidic and basic residues. The hydrophobic region on the 'bottom' surface of the domain near the C-terminal helix binds the leading strand DNA, whilst the hydrophobic region on the 'top' surface of the domain lies between the two arms of the fork DNA, allowing for T4 gene 41 helicase binding and assembly into a hexameric complex around the lagging strand [1].	25.00	25.00	64.70	63.90	21.70	21.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.07	0.72	-3.87	10	58	2009-01-15 18:05:59	2006-08-04 09:03:10	5	2	56	1	0	50	390	101.80	38	50.40	CHANGED	F+EDl+slhYFucKhsls.hcclFpYspcspoShIFKLlQoshIShETFllLDSFLsIlD+aDc.hssDllWps.apsKlpAY+KLlsIDsc...pAKslFIcslcppK	......................Fc-DlcslhhFucpsthpthcclFp.sscsppshIhKhlQSshIShETFllLDShLshl-caDc.ptsDllWps.auhKlpuY+KlLsIDsp...csKplFl-Tl+sh....	0	0	0	0
+8827	PF08995	NIP_1		Necrosis inducing protein-1	Mistry J, Sammut SJ	anon	pdb_1kg1	Domain	Necrosis inducing protein-1, a fungal avirulence protein produced by plants, consists of two parts containing beta-sheets of two and three anti-parallel strands, respectively. Five intramolecular disulfide bonds, stabilise these parts and their position with respect to each other, providing a high level of stability [1].	25.00	25.00	186.20	186.00	20.10	18.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.14	0.72	-3.81	3	16	2009-01-15 18:05:59	2006-08-04 09:05:11	5	1	1	1	0	17	0	82.00	96	100.00	CHANGED	MKFLVLPLSLAFLQIGLVFSTPDRCRYTLCC-GALKAVSECLHESESCLVPGDCCRGKSRLTLCSYGEGGNGFQCPTGYRQC	MKFLVLPLSLAFLQIGLVFSTPDRCRYTLCCDGALKAVSECLpESESCLVPGDCCRGKSRLTLCSYGEGGNGFQCPpGYRQC	0	0	0	0
+8828	PF08996	zf-DNA_Pol		DNA Polymerase alpha zinc finger	Mistry J, Sammut SJ	anon	pdb_1n5g	Domain	The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. Function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain [1].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.62	0.71	-4.94	40	326	2009-01-15 18:05:59	2006-08-04 09:06:55	5	14	267	7	211	330	1	179.70	29	13.00	CHANGED	l-opl.oDsp+a+ssspLplpC..spCspphhFsG...........lhs.......ssstphpssGlpCsp......Cst..hhsshpltsQLphtIRpalshYYpGWllC--ssCss+.TRQlslhu+R....Cl......................sC.+GpMph-Yo-+pLYNQLhYapuLFDl-+shppthp..................pptptcpl.hhspps+phappl+ssV-caLscsGhphVshu.slF	................................................................................sph.sDp.+a+sspthphpC.....p..Ctpp.has.u........................lhp......................tsspt.h..p..ss...h...h..tCsp......Cpt...............hh.s..hplsspLphplRphl.pcYY.pG.WL.lC-DssC...s..p.c...TRp..hsl..hs.p.R..................C.............................sC..pGphp..hcYo-+pLYsQLhYapt.lFDs-pshpph.t............................tttp.ppph..hh.s.tp.p.....thattlpsslc.phLpcsuhphVshsplF................................	1	74	116	172
+8829	PF08997	UCR_6-4kD		Ubiquinol-cytochrome C reductase complex, 6.4kD protein	Mistry J, Sammut SJ	anon	pdb_1sqq	Domain	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is an essential component of the mitochondrial cellular respiratory chain. This family represents the 6.4kD protein, which may be closely linked to the iron-sulphur protein in the complex and function as an iron-sulphur protein binding factor [1].	24.00	24.00	24.10	24.60	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.68	0.72	-4.26	5	96	2009-01-15 18:05:59	2006-08-04 09:08:46	5	2	70	17	55	108	0	53.60	42	80.45	CHANGED	Mlo+l.lGsKYsElA+uWlPoussWGuAGGVALVaFTDWRLlLDYVPYlNuKFcKDE	...........hh.+h.hG.+ahplspsWlPosusaGusuuluLlahTD.W..+LILsaVPahsGKFccs......	0	16	18	33
+8830	PF08998	Epsilon_antitox		Bacterial epsilon antitoxin	Mistry J, Sammut SJ	anon	pdb_1gvn	Domain	The epsilon antitoxin, produced by various prokaryotes, forms part of a postsegregational killing system which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it [1].	25.00	25.00	43.50	42.80	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.08	0.72	-4.01	3	79	2009-09-10 22:13:13	2006-08-04 09:09:58	6	2	68	4	1	25	0	85.90	77	95.90	CHANGED	AVTYEKTFEIEIINELSuSVYNRVLNYVLNHELDKsDSpLLEVNLLNQLclApcVNLFchSLEELQAlHEYWRSMN+YSKQILsKEKVA	.AVTYEKTFEIEIINELSASVYNRVLNYVLNHELsppDopLLEVNLLNQLclApcVsLFp.shEELQAlHEYWRSMNpYSKQlLsKEKVA...................	0	0	0	1
+8831	PF08999	SP_C-Propep		Surfactant protein C, N terminal propeptide	Mistry J, Sammut SJ	anon	pdb_2esy	Domain	The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. It's main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide [1].	25.00	25.00	28.30	27.80	23.00	21.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.27	0.72	-4.50	3	104	2009-01-15 18:05:59	2006-08-04 09:13:37	5	3	70	7	22	92	0	62.70	80	51.94	CHANGED	MDMGSKEVLMESPPDYSAuPRGRFRIPCCPVHLKRLLIVVVVVVLVVVVIVGALLMGLHMSQKHTEMVLEMSIGG.PEsQQRLALSE+sGTTAT	..................................FtIPCCPVpLKRLLIVVVVVVLVVVVIVGALLMGL...................................................	0	1	1	5
+8832	PF09000	Cytotoxic		Cytotoxic	Mistry J, Sammut SJ	anon	pdb_1e44	Domain	The cytotoxic domain confers cytotoxic activity to proteins, enabling the formation of nucleolytic breaks in 16S ribosomal RNA. The structure of the domain reveals a highly twisted central beta-sheet elaborated with a short N-terminal alpha-helix [1].	21.10	21.10	21.10	22.90	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.00	0.72	-3.96	5	56	2009-01-15 18:05:59	2006-08-04 09:15:10	5	19	47	6	17	71	1	81.20	38	15.33	CHANGED	YHPAPKsptlsGLssL..+.stpKTPhQuGGuKRKRWpssKG....++IYEWDSpHGElEVYc.S+G+HLGShDPpTG-.lKssV+GRoIKt.l	.............................t....l.uhsth....st.KTs..hpGGGshRtR...WhspKG......cpIYEWDSQH....G....clEsYc..pcGc.HLGpFDPpTGcpl..Ks.ss..tRplc.h...............	0	4	6	11
+8833	PF09001	DUF1890		Domain of unknown function (DUF1890)	Mistry J, Sammut SJ	anon	pdb_1kjn	Domain	This domain is found in a set of hypothetical archaeal proteins.	25.00	25.00	136.10	135.90	24.70	19.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.73	0.71	-4.17	14	40	2009-01-15 18:05:59	2006-08-04 09:16:13	6	1	39	2	30	39	2	141.30	40	93.70	CHANGED	llllGCPEsPVQhshslYLsptLcctGhclllAuNPAAh+LlcVADP-+aYlcch..h-lDcsltplttt..sh-hhhuFsHNDAulsYssTh.ttl.pscshullFG+c.s--Lscplp.....hssphlsu+AhHNPhPLps+l-clh	LllLGCPEsPlQsPhslYLsptL+ccGacVslAuNPAAhKLlcluDPE+aYlppl..h-lDcslpslttt..-hDhlhuFlHNDAuloYhsTa.ptlhpsc.shAlVFG+c.s--Lschlc....thsschlsuRAaHNPtPLps+l-+lh...	0	7	19	25
+8834	PF09002	DUF1887		Domain of unknown function (DUF1887)	Mistry J, Sammut SJ	anon	pdb_1xmx	Domain	This domain is found in a set of hypothetical bacterial proteins.	23.90	23.90	23.90	23.90	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.31	0.70	-6.06	6	279	2012-10-11 20:44:44	2006-08-04 09:20:15	6	6	251	1	59	213	19	305.10	28	86.60	CHANGED	MtlHVslls.QcsspLIssLLDpth+sc+hVFIsocsp..+EthpRLcplLp.pGIss....-hFplsstsshptl+pplpsLhE-hKh.ssElhLNsosGh+hhhLuAYEsFR.ShHhPIahl-ssSDclpaL.PsGscptpV.pcpIp..luDYLssaGA......Rst.u-sphscphsc+LhpLupRaAosAh-hGshLuoLNhLAoss..R+tphlslclo-cptuY.+-LshLlsDLs-ssLssa-sGl.lTFtsE-ARRFhNGpWLEhhVaspl+sIpp....lpDhuLsVQVhcchsEKp...VRNELDVVslssNKLHIIECKTtGhccDu.....DDTLYKLESLRD.LGGLpuRuhLVSFRPlpssDlh..RApchsltlIGPDELsDLKcHLpsWhpts	.......................................................................................hhs.p....p.............th.s.p..chlhlh...sppt..........hhp.pL.p..p.hhp....h..th...p.............ch.hp.l.s.s..................shptlp...ptl.pp.lh.pphc........sccl..hhNhosGh+h..hhLusa.p.hh.p..php..h..s.....l.......h.hh-spps..p..h.hhl..ts...p....p....p..pl....sp.lp..ltshlshhGs.........p.th...p.........h......pht.p..hsp....h.......p....h...h...l................sph...h.tpps.......p......ph...p.th..ppp...t.hh...t.......p.l....l.s....L....ctt...h...h.....p.....h...p....pt....h.....h.....sF..s....c...p...h...+p......F..h..s..GpW.LEhhl.atpl.pphpp........l..pDhp...hs....l.....pl...h..hp.....h..t..-pc.................lpN....ELDVshh.h.ssp.L.hlIECKo.psh.....p..s-.s.............hLh+..Lpsh..tchhG.G.pscthL..Vs.h...t....hp....s.....h........Rspph...tl..l.l....tp.h..th...l.t....s...............................................................................	1	24	44	53
+8835	PF09003	Phage_integ_N		Bacteriophage lambda integrase, N-terminal domain 	Mistry J, Sammut SJ	anon	pdb_1kjk	Domain	The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage [1].	21.80	21.80	22.10	23.00	21.40	21.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.61	0.72	-4.27	17	707	2012-10-03 08:51:45	2006-08-04 09:34:33	5	9	359	8	34	331	1	71.50	43	19.78	CHANGED	MutRsRphs.hslP.NLhtp.s.+...sYapY+sPlTGK.aGLGp.D+ppAhspAhpANhplhpptscthLhpp.pss	..........MutR.Rpac..pclP.sLY.+.s....s....+s...YapYRcPlTGKpaGLGp.DcchAhs.AhpANpcltptptcphLshp.c.h.......................	0	7	19	27
+8836	PF09004	DUF1891		Domain of unknown function (DUF1891)	Mistry J, Sammut SJ	anon	pdb_2cq2	Domain	This domain is found in a set of hypothetical eukaryotic proteins.	20.60	20.60	20.60	20.70	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-8.06	0.72	-4.57	9	72	2009-01-15 18:05:59	2006-08-04 10:05:59	5	14	28	6	42	109	0	38.20	39	7.06	CHANGED	WosNpsulhKKAQQRLaFLRpL+Ksphs....shhh+usIES	.......hssNp....puhhKhuppchhFLRK.pKs+h......sLhh+psIEo....	0	13	14	30
+8837	PF09005	DUF1897		Domain of unknown function (DUF1897)	Mistry J, Sammut SJ	anon	pdb_2bn5	Domain	This domain is found in Psi proteins produced by Drosophila, and in various eukaryotic hypothetical proteins. It has no known function.	20.10	20.10	20.30	20.10	19.70	20.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.05	0.72	-4.50	12	369	2009-01-15 18:05:59	2006-08-04 10:08:04	5	23	86	2	175	293	0	32.50	48	8.58	CHANGED	ssssssGpsDYSApWhEYYRphGhhcpA-hlcpphtt.p	..........ssssuGQ.sDYSAAWtEYY+p..G...pAthhtt.....s............	1	36	48	112
+8838	PF09006	Surfac_D-trimer		Lung surfactant protein D coiled-coil trimerisation	Mistry J, Sammut SJ	anon	pdb_1m7l	Domain	This domain, predominantly found in lung surfactant protein D, forms a triple-helical parallel coiled coil, and mediates trimerisation of the protein [1].	20.70	20.70	20.70	20.80	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.22	0.72	-4.23	10	72	2009-01-15 18:05:59	2006-08-04 10:14:29	6	6	32	67	37	66	0	42.60	52	13.77	CHANGED	VsALRQQVEsLpGpLQRLQsAFSQYKKAsLFPDGQSVGEKIFKTAG	..................lsuL+QQlpsLptplppLQsuhSpYKKstLFPsGpuVGcKIFKTuG.....	0	1	1	6
+8839	PF09007	EBP50_C-term		EBP50, C-terminal	Mistry J, Sammut SJ	anon	pdb_1sgh	Domain	This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control [1].	25.00	25.00	46.10	45.00	20.20	19.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.89	0.72	-4.10	6	149	2009-01-15 18:05:59	2006-08-04 10:16:42	6	4	37	9	55	106	0	40.90	60	12.56	CHANGED	-ssLcLshShAtAKE+A+.ppRupKRAPQMDWSK+pElFSNh	.....-ssLcl..u.osAtAKE+A+.tpRssKRAPQMDWsKKpElFSNh.	0	2	8	21
+8840	PF09008	Head_binding		Head binding	Mistry J, Sammut SJ	anon	pdb_1lkt	Domain	The head binding domain found in the Phage P22 tailspike protein contains two regular beta-sheets, A and B, oriented nearly perpendicular to each other and composed of five and three strands respectively. The topology of the strands is exclusively antiparallel. The tailspike protein trimerises through this domain, and the direction of the strands with respect to the molecular triad is almost parallel for beta-sheet A, whereas beta-sheet B is perpendicular to the triad, forming a dome-like structure. This domain is dispensable for thermostability and SDS resistance of the intact protein, and its deletion has only minor effects on tailspike folding kinetics [1].	21.50	21.50	24.60	23.60	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.47	0.71	-4.04	5	167	2009-09-11 14:20:10	2006-08-04 10:18:20	5	10	154	22	13	147	0	109.70	70	16.69	CHANGED	MTDITsNlVVSMPSQlFTtsRuFKAVANGKIYIGKIDTDPVNPsNQIPVYlENEDGSaVpVAQPIIINAAGaPVYNGQIAKFVTVQGHSMAVYDAsGAQQFYFsNVLKYDPcph	..........MoD.ITANVVVSMPoQLFTMuRSFKAVANGKIYIGKIDTDP...VNPpNQIpVYlENEDGSHVsVoQPIIINAAGaPVYNGQ.IAKFVTVQGHSMAVYD..AYGuQQFYFPNVLKYDPDQ..........	0	2	2	6
+8841	PF09009	Exotox-A_cataly		Exotoxin A catalytic	Mistry J, Sammut SJ	anon	pdb_1aer	Domain	Members of this family, which are found in prokaryotic exotoxin A, catalyse the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis [1].	25.00	25.00	26.80	36.00	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.62	0.70	-5.47	2	67	2009-01-15 18:05:59	2006-08-04 10:19:20	5	3	24	45	1	86	0	202.00	71	36.78	CHANGED	A.lphp..oGtpaLs-stsl.hospGspNWThpcL.tsHptLpccGYVFVGYHGT.h.AAQoIV..husV.Rupsp-.-thWtGhYlAscstlAaGYAp.pE.......PstttR.tpGshLRVYlPRuSL.tFYRTshsLtssEt..clpplIGHsLPLR.-AhTGPEptGGc.ETllGWshA.+sVsIPSsIPssshp.thslD.puls.KEQuISshPsY.....K..+--LK	ANINIESRSGRSYLPENRAV.ITPQGVTNWTYQELEATHQALTREGYVFVGYHGTNHVAAQTIVNRIAPVPRGNNTENEEKWGGLYVATHAEVAHGYARIKEGTG-hGLPTRAER-sRGVMLRVYIPRASLERFYRTNTPLENAEc..HITpVIGHSLPLRNEAFTGPEusGGEDETVIGWDMAIHAVAIPS............................................	0	1	1	1
+8842	PF09010	AsiA		Anti-Sigma Factor A	Mistry J, Sammut SJ	anon	pdb_1jr5	Domain	Anti-sigma factor A is a transcriptional inhibitor that inhibits sigma 70-directed transcription by weakening its interaction with the core of the host's RNA polymerase. It is an all-helical protein, composed of six helical segments and intervening loops and turns, as well as a helix-turn-helix DNA binding motif, although neither free anti-sigma factor nor anti-sigma factor bound to sigma-70 has been shown to interact directly with DNA. In solution, the protein forms a symmetric dimer of small (10.59 kDa) protomers, which are composed of helix and coil regions and are devoid of beta-strand/sheet secondary structural elements [1].	25.00	25.00	25.90	77.90	22.00	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.01	0.72	-4.11	6	30	2009-01-15 18:05:59	2006-08-04 10:21:43	5	1	29	6	0	23	0	88.50	46	97.68	CHANGED	M........Nts.Ehl+-IIuhASlLIKFupE.DIlssQpsFluFLNElGh+ossGc-FTpsSFRQMhsRLst-p+cELl-pFN.pGacslh+phhMYoNs	...MshplEhV+EIIolASILIKFupE.DIl-sRssFIAFLNElGl+s.pG+cLspsSFRclhpcLTp--+cpLI-EFN.pGa.EslaRhLhMYos.....	0	0	0	0
+8843	PF09011	HMG_box_2	DUF1898;	HMG-box domain	Mistry J, Sammut SJ, Coggill P	anon	pdb_2cto	Domain	This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.46	0.72	-3.61	10	1103	2012-10-02 14:16:02	2006-08-04 10:25:46	5	49	229	12	522	7615	215	70.30	37	19.76	CHANGED	PsKPKushsAYhaFspcppsEhK+c......tP..ssshuEhoKtsSpcW+shSscEKccYp-pA+tcKscacpEhtsac	........................................KP..+..s.t.h.Su.Y.s.hF....lp.s....p....p....p....-....t.Kcc........................ps.......slsh..u.Eh..s..K.....c...C..S..E.+.................W..K..........s...h..Ss........c........E...Ksc..a...c.-....h...A+.....t...D..K.t.+.Y.-pEMpsa.h...................................	0	146	190	303
+8844	PF09012	FeoC	DUF1920; 	FeoC like transcriptional regulator	Mistry J, Sammut SJ	anon	pdb_1xn7	Domain	This family contains several transcriptional regulators, including FeoC, which contain a HTH motif.  FeoC acts as a [Fe-S] dependant transcriptional repressor [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.29	0.72	-4.27	36	803	2012-10-04 14:01:12	2006-08-04 09:28:13	5	3	792	2	109	876	60	71.10	45	86.96	CHANGED	hLppl+palppcspsShs-Lup+Fphs.sslcuMLshWlpKG+lp+h.sssss.....uuuCpp......Ct.....tt.p....shYc	..................SLlQVRDh..LA.L.+.GR.h-AsQISppLs..sPpPhIsAMLppLEpMGKss.RIp--scGC...............LSGSCKS.CP.....EG+s........shcphh................................	0	29	58	82
+8845	PF09013	YopH_N		YopH, N-terminal	Mistry J, Sammut SJ	anon	pdb_1huf	Domain	The N-terminal domain of YopH is a compact structure composed of four alpha-helices and two beta-hairpins. Helices alpha-1 and alpha-3 are parallel to each other and antiparallel to helices alpha-2 and alpha-4. This domain targets YopH for secretion from the bacterium and translocation into eukaryotic cells, and has phosphotyrosyl peptide-binding activity, allowing for recognition of p130Cas and paxillin [1].	19.60	19.60	19.70	135.40	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.50	0.71	-4.45	4	68	2009-09-11 06:44:49	2006-08-04 10:34:58	5	2	31	4	6	18	0	114.70	61	40.01	CHANGED	hpIssLpp.lS.plsp.tsG-phG+L+........sThQtlo.opuhpssEKsFAppVLcHVpNssLspcDlApLL......phsNaEL+pstsGpslLsGLRo-QLoLpDAKlLL-AAhRQ	.hplssLpp.ls.plsQ.tpGspsG+Lp........pT..hhp.upthppuEKsFAppVLpHVtNssLopcDhApLL......plsNhEL+pstsGpsllsuLRo-QhoLpDAKlLLEAAhRQ.	2	0	2	2
+8846	PF09014	Sushi_2		Beta-2-glycoprotein-1 fifth domain	Mistry J, Sammut SJ	anon	pdb_1g4f	Domain	The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. It plays an important role in the binding of b2GP-1 to negatively charged compounds and subsequent capture for binding of anti-b2GP-1 antibodies [1].	22.10	22.10	22.10	23.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.07	0.72	-4.22	6	79	2009-01-15 18:05:59	2006-08-04 10:39:08	5	8	40	7	37	69	0	82.80	44	22.33	CHANGED	RAsCpVPlK+upVlYsGhKhhltDltcshlhHG-+VoFaCKspcK+CSasssupChDGslplPuCacE.s.Ltah...+p.sS-lpsC	.............+AsCplslK+upVlYpGc+lplp-hhcsshhHG-pVoFaCKNK..E.K.+CSYotsupChDGslclPpCFc.E.o.lt.ah...+o.sS-lpsC..............	0	1	6	19
+8847	PF09015	NgoMIV_restric		NgoMIV restriction enzyme	Mistry J, Sammut SJ	anon	pdb_1fiu	Domain	Members of this family are prokaryotic DNA restriction enzymes, exhibiting an alpha/beta structure, with a central region comprising a mixed six-stranded beta-sheet with alpha-helices on each side. A long 'arm' protrudes out of the core of the domain between strands beta2 and beta3 and is mainly involved in the tetramerisation interface of the protein. These restriction enzymes recognise the double-stranded sequence GCCGGC and cleave after G-1 [1].	20.70	20.70	21.20	27.80	19.50	20.40	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.90	0.70	-5.41	6	56	2012-10-11 20:44:44	2006-08-04 10:56:01	5	2	50	6	9	43	3	239.70	54	95.23	CHANGED	FH+pLl.-GslhhsN...........stu..lsSNADuSsspSpslApGltcplpu.polsc+h.....AGQTsGspFEcIsppFlccTFp+lpHLRPGsWpVppssutp+hp.IspaEQYuHLtcLs+lu+cpsELuuuLGsDYsIpPDIVlsRcstsDptIN.csc.LVD..ssssthos.LR+uN....supP..lLHASISCKWTIRSDRAQNTRoEALNLlRNRKGRlPHIVsVTAEPhPSRIuSlALGTGDIDCVYHhALsELppulpulGp-Dst-hLpshIsG+RL+DISDLPLDLul	..................FHtpLl.psslhhhN...........stG..VsSNADuSNppShsIApuIAchLtu.coluc+l.....sGQTuGstFEslsscFlppsF.+LpHlRPG.sWsVppluupsRhc.IucapQYsHLssLscAscpss-LAAALGsDYsIoPDIlVsRp..sDttIN.psphLV..D..-s.lsphus.LRtsN.....ushP...lLHASISCKWTIRSDRAQNARSEuLNLlRNRKGRLPHIVVVTAEPoPSRluSIALGTG-IDCVYHFAL.ELppslpsl..s.......h-DAh.....-hhhhMVsG+RLKDISDLPLDLAV..........................	1	2	7	7
+8848	PF09016	Pas_Saposin		Pas factor saposin fold	Mistry J, Sammut SJ	anon	pdb_2b8i	Domain	Members of this family adopt a compact structure comprising five alpha helices. Charged and polar residues are exposed mostly on the surface, while most of the hydrophobic residues are buried inside the hydrophobic core of the helical bundle. The precise function of this domain is unknown, but it is has been shown to induce secretion of periplasmic proteins, especially collagenase [1].	27.50	27.50	123.30	123.20	27.30	27.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.37	0.72	-3.98	6	38	2009-01-15 18:05:59	2006-08-04 10:57:41	5	1	33	1	8	27	0	75.40	68	99.10	CHANGED	hpoLIY-TLhNLAsp-PEQHApIRQpLYEQLDLsF-KQLALYusVLGPASSGKLtspcslscAV-pAlclLEh.p+	MKTLIY-TLlsLAsQEPEQHApIRQNLYEQLDLPFDKQLALYSsALGPASSGKLEsppuIsNAVDsAl+LLEsPE+.	0	0	1	6
+8849	PF09017	Transglut_prok		Microbial transglutaminase	Mistry J, Sammut SJ	anon	pdb_1iu4	Domain	Microbial transglutaminase (MTG) catalyses an acyl transfer reaction by means of a Cys-Asp diad mechanism, in which the gamma-carboxyamide groups of peptide-bound glutamine residues act as the acyl donors. The MTG molecule forms a single, compact domain belonging to the alpha+beta folding class, containing 11 alpha-helices and 8 beta-strands. The alpha-helices and the beta-strands are concentrated mainly at the amino and carboxyl ends of the polypeptide, respectively. These secondary structures are arranged so that a beta-sheet is surrounded by alpha-helices, which are clustered into three regions [1].	25.00	25.00	722.90	722.60	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.37	0.70	-5.36	4	22	2009-01-15 18:05:59	2006-08-04 11:06:04	5	1	10	5	0	27	0	397.00	82	99.39	CHANGED	MppRRRhLsFATlGAVlCTAGhMPSsupA....AuuGsGEEctSYAETHcLTADDVcsINALNEpA.sAupsG.......PS....FRAPDu...DDRVTPPAEPLDRMPDsYRs.hGRApTVVNNYIRKWQQVYSHRDG+KQQMTEEQREhLSYGCVGVTWVNSG.YPTNRLAFA.FDEsKYKN-LKNuRPRssETRAEFEGRlAK-SFDEuKGFpRAR-VASVMNKALENAHDEusYlsNLKpELANsNDALhpEDuRSsFYSALRNTPSFKERsGGNaDPSKMKAVIYSKHFWSGQDppGSSDKRKYGDP-AFRPspGTGLVDMSRDRNIPRSPspPGEuaVNFDYGWFGAQTEADADKTVWTHGNHYHAPNGuLGsMHVYESKFRNWSsGYuDFDRGAYVITFIPKSWNTAPsKVcQGWP	..................M..RtphLsFAThuAllCsuGhhPSsupA....AssGsGEpctSYAETHtLTA-DVcNINALNcpA.ssupsG.......PS....FRAPDu...DDRVTPPAEPLDRMPDsYRs.hGRApTVVNNYIRKWQQVYSHRDG+KQQMTEEQREhLSYGCVGVTWVNSG.YPTNRLAFAFFDEsKYKN-LKNuRPRssETRAEFEGRlAK-SFDEuKGFpRAR-VASVMNKALENAHDEGsYlDNLKpELANtNDALhpEDuRSsFYSALRNTPSFKERsGGNaDPSKMKAVIYSKHFWSGQDppGSSDKRKYGDP-AFRPDpGTGLVDMS+DRNIPRSPspPGEuaVNFDYGWFGAQTEADADKTlWTHGNHYHAPNGuLGsMHV.YESKFRNWSsGYuDFDRGs.YVITFIPKSWNTAPsKVKQGWP..................	0	0	0	0
+8850	PF09018	Phage_Capsid_P3		P3 major capsid protein	Mistry J, Sammut SJ	anon	pdb_1hqn	Domain	The P3 major capsid protein adopts a 'double-barrel' structure comprising two eight-stranded viral beta-barrels or jelly rolls, each of which contains a 12-residue alpha-helix. This protein then trimerises through a 'trimerisation loop' sequence, and is incorporated within the viral capsid [1].	25.00	25.00	937.50	937.30	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.38	0.70	-5.88	3	7	2009-01-15 18:05:59	2006-08-04 11:10:51	6	1	6	78	0	6	0	394.00	100	99.75	CHANGED	AQVQQLTPAQQAALRNQQAMAANLQARQIVLQQSYPVIQQVETQTFDPANRSVFDVTPANVGIVKGFLVKVTAAIKNNHATEAVALTDFGPANLVQRVIYYDPDNQRHTETSGWHLHFVNTAKQGAPFLSSMVTDSPIKYGDVMNVIDAPATIAAGATGELTMYYWVPLAYSETDLTGAVLANVPQSKQRLKLEFANNNTAFAAVGANPLEAIYQGAGAADCEFEEISYTVYQSYLDQLPVGQNGYILPLIDLSTLYNLENSAQAGLTPNVDFVVQYANLYRYLSTIAVFDNGGSFNAGTDINYLSQRTANFSDTRKLDPKTWAAQTRRRIATDFPKGVYYCDNRDKPIYTLQYGNVGFVVNPKTVNQNARLLMGYEYFTSRTELVNAGTISTT	AQVQQLTPAQQAALRNQQAMAANLQARQIVLQQSYPVIQQVETQTFDPANRSVFDVTPANVGIVKGFLVKVTAAIKNNHATEAVALTDFGPANLVQRVIYYDPDNQRHTETSGWHLHFVNTAKQGAPFLSSMVTDSPIKYGDVMNVIDAPATIAAGATGELTMYYWVPLAYSETDLTGAVLANVPQSKQRLKLEFANNNTAFAAVGANPLEAIYQGAGAADCEFEEISYTVYQSYLDQLPVGQNGYILPLIDLSTLYNLENSAQAGLTPNVDFVVQYANLYRYLSTIAVFDNGGSFNAGTDINYLSQRTANFSDTRKLDPKTWAAQTRRRIATDFPKGVYYCDNRDKPIYTLQYGNVGFVVNPKTVNQNARLLMGYEYFTSRTELVNAGTISTT	0	0	0	0
+8851	PF09019	EcoRII-C		EcoRII C terminal	Mistry J, Sammut SJ	anon	pdb_1na6	Domain	The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites [1].	20.30	20.30	20.30	20.70	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.92	0.71	-4.40	14	145	2012-10-11 20:44:45	2006-08-04 11:12:05	6	2	130	13	25	144	16	164.70	40	44.93	CHANGED	F+hhEctllhp+lptGFs......sVDsFl........sauhSVpNRRKSRAG+SLE.HLcplhpstGl....pasppu...hT.....EssKKPDFLFPusstYc......sstFPscpLpMLusKTTCKDRWRQVLsEA-R..IcpKHLhTLp.G.lSpsQhpEMpcpslpLVVPpsl+poYspp.+scLhTlpsFI	...........................................FhhhEchhh.phlppsas........slDpFl........shupS.l.....sNRRKSRAGKSLEhHLcplF.ctGl....pFpsQA........hT...........Es..sKK...PDFL.FPuutsY+............s.tFs.scpLpMLusKTTCKDRWRQlLsEA......-..R......I..p..phaLhTLp-G.lStsQhpEMpcpslpLVVPp.slpcp..aspthpsplholtsFI.................	0	11	17	22
+8852	PF09020	YopE_N		YopE, N terminal	Mistry J, Sammut SJ	anon	pdb_1l2w	Domain	The N terminal YopE domain targets YopE for secretion from the bacterium and translocation into eukaryotic cells [1].	21.60	21.60	24.20	78.80	20.70	18.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.75	0.71	-4.09	2	31	2009-01-15 18:05:59	2006-08-04 11:19:43	5	1	27	6	2	13	0	104.70	97	52.96	CHANGED	MKISSFISTSLPLPTSVSGSSSVGEMSGRSVSQQpS-QYANNLAGRTESPQGSSLASRIhE+LSShAHSsItFIpRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLsSLDA	..........................MSGRSVSQQpSDQYANNLAGRTESPQGSSLASRIIERLSShAHSVIGFIQRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLNSLDA	0	0	1	1
+8853	PF09021	HutP		HutP	Mistry J, Sammut SJ	anon	pdb_1wmq	Domain	The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognises three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg2+ ions are also required. These proteins exhibit the structural elements of alpha/beta proteins, arranged in the order: alpha-alpha-beta-alpha-alpha-beta-beta-beta in the primary structure, and the four antiparallel beta-strands form a beta-sheet in the order beta1-beta2-beta3-beta4, with two alpha-helices each on the front (alpha1 and alpha2) and at the back (alpha3 and alpha4) of the beta-sheet [1].	25.00	25.00	41.80	41.50	24.20	23.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.44	0.71	-3.93	17	271	2009-01-15 18:05:59	2006-08-04 11:30:01	6	2	242	36	67	175	0	131.60	41	90.58	CHANGED	+lu+sAlhhAlopocEEEtplcphh.tppsh+ssssclGGp..h.psspKllcsslsAAK+pGVIpcs.ap-ptAlhtAThEAlptlhspshulss.....GhKluIsR........cs-alAVAlahslGlhhL..-c.slGLGhp	...pluRhAhhlAlupppEppthh.p....htcGh+ssssclGu......sspKlltuh.sAAKpstVIcss.ap-ptAlhtAhhEALhtltp.ttltLss.....Gh+huIsR........puEaluVAlassIGh.hh...-c.uIGLGhp.............	0	30	50	58
+8854	PF09022	Staphostatin_A		Staphostatin A	Mistry J, Sammut SJ	anon	pdb_1oh1	Domain	The staphostatin A polypeptide chain folds into a slightly deformed, eight-stranded beta-barrel, with strands beta-4 through beta-8 forming an antiparallel sheet while the N-terminus forms a a psi-loop motif. Members of this family constitute a class of cysteine protease inhibitors distinct in the fold and the mechanism of action from any known inhibitors of these enzymes [1].	24.10	24.10	24.10	24.10	23.40	23.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.28	0.72	-4.20	3	151	2012-10-01 18:54:33	2006-08-04 11:30:27	5	1	150	1	2	24	0	105.00	74	97.89	CHANGED	McpYpLINIccscscapEKYWLHILEGlWHPp-lsTSPLKITFNKsIsPsYICKhINEDSR+IILsNsDNoNIIIEIIIINc+KIlFNllNKEuLGTSPKITFIK	MEQhELFSIDKF..KCNSEAKYYLNIIEGEWHPQDLNDSPLKFILSTSDDSDYICKYINTEHKQLTLYNKNNSSIVIEIFIPNDNKILLTIMNTEALGTSPRMTFIK...	0	1	1	2
+8855	PF09023	Staphostatin_B		Staphostatin B	Mistry J, Sammut SJ	anon	pdb_1y4h	Domain	Staphostatin B inhibits the cysteine protease Staphopain B, produced by Staphylococcus aureus, by blocking the active site of the enzyme. The domain adopts an eight-stranded mixed beta-barrel structure, with a deviation from the up-down topology of canonical beta-barrels in the amino-terminal part of the molecule [1].	25.00	25.00	30.10	30.00	22.20	19.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.35	0.72	-4.23	2	163	2012-10-01 18:54:33	2006-08-04 11:32:06	5	1	163	8	2	15	0	107.00	97	98.19	CHANGED	MYQLpFIpls.DshpLT+.cQssIpLFIGNW.N.phQKSIsIRpGsDTsHNQYpIL.IDTtHQRIKhoS.-s.plhYILDY-DTpHIhhQTSsKpuhGTSRPIhYE+	...MYQLQFINLVYDTT.KLTHLEQTNINLFIGNWSNHQLQKSICIRH..GD.DTSHNQYHILFIDTAHQRIKFSSIDNEEIIYILDYDDTQHILMQTSSKQGIGTSRPIVYER.	0	1	1	2
+8857	PF09025	YopR_core		YopR Core	Mistry J, Sammut SJ	anon	pdb_1z21	Domain	The YopR core domain, predominantly found in the Yersinia pestis virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR [1].	25.00	25.00	98.30	98.10	22.20	21.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.90	0.71	-4.19	9	74	2009-01-15 18:05:59	2006-08-04 11:50:47	5	1	69	1	9	35	16	140.50	43	81.11	CHANGED	s-ushh....p+hp.sssL-shLus.sPuspRElLW.hap.....pGscpss...ppLhtslppcLlucFuGp.hsl.sshDhsEL+uhlppa.PLGup+EpsLLplhu-LKsh.....PshtaLs-LsRcEL.hLIPhNuMVcNLh+pSHKLDLE	.......................................................s-lhspLEptLpuEssptsRElLW.ta......Ausssst...p.Lhss.lcEcLLuRFuQp.tsl.PshDhsEL+uhLppa.shG+ppEshLLQlLtulKss.....sGh.YLu-Llp+EL.lLlPhNuhVDNLl+NSHKlDh-	0	1	3	4
+8858	PF09026	CENP-B_dimeris	Cenp-B_dimeris;	Centromere protein B dimerisation domain	Mistry J, Sammut SJ	anon	pdb_1ufi	Domain	The centromere protein B (CENP-B) dimerisation domain is composed of two alpha-helices, which are folded into an antiparallel configuration. Dimerisation of CENP-B is mediated by this domain, in which monomers dimerise to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation [1].	24.30	24.30	24.30	24.50	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.46	0.72	-3.77	2	32	2012-10-08 13:44:34	2006-08-04 11:51:16	5	5	24	4	19	37	1	93.70	69	22.07	CHANGED	PTLHFLEGtEDS-SDS-EEE-D--EDE..-DE-D-E-sDEVPVPSFGEAMAYFAMVKRYLTS.PIDDRVQSHILHLEHDLVHVTRKNHARQAGsRGLGHQS	............PTLHFLEGtEDS-SDS-EE--..-E--..D---.-.D-D.D-EDsD.EVPVPSFGEAMAYFAMVKRY..LTSFPIDDR....VQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS..................	0	4	4	7
+8859	PF09027	GTPase_binding		GTPase binding	Mistry J, Sammut SJ	anon	pdb_1cf4	Domain	The GTPase binding domain binds to the G protein Cdc42, inhibiting both its intrinsic and stimulated GTPase activity. The domain is largely unstructured in the absence of Cdc42 [1].	21.30	21.30	22.10	21.30	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.12	0.72	-4.38	5	170	2009-01-15 18:05:59	2006-08-04 11:51:45	5	14	62	1	77	128	0	62.20	49	7.74	CHANGED	AGlSAQDIpVPLKsGFlHoG+GhuNsR+C.WGsPucF-NsYLs..hDP.shhhspLSsA..tPTQHLuslG	......AGlSAQDISpPLpsSFIHT..GHGDu..sP++C.WGhPD+ID-lYLsNPMDPPDlhss..p...usu....tph.stht........................	0	15	22	43
+8860	PF09028	Mac-1		Mac 1	Mistry J, Sammut SJ	anon	pdb_2avw	Domain	The bacterial protein Mac 1 adopts an alpha/beta fold, with 14 beta strands and 9 alpha helices. The N-terminal domain is made up predominantly of alpha helices, whereas the C-terminal domain consists predominantly of beta sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity [1].	20.10	20.10	20.20	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.26	0.70	-5.67	3	78	2009-01-15 18:05:59	2006-08-04 12:34:31	5	9	60	8	13	76	1	280.70	32	54.08	CHANGED	KhsDuIuAPVlApsplhVcMKV.DRGlEs-sapsDsEV....cTSEss.YcVTchcc.................lWs+GlTPPAhFspGGhV.........apAPahAtpGaYDhNKolNG+..DlsLCaAATASNMLHWWFEQNs-YIEpYLKc..cKQKlslGEphclLDlR+YIcohQDQsN...SclFNhFRsh...uausRRsGalsDuLlDhFINGYYLpV.+sGssNLscoY...DpRGGlFsDVFs+sspsKpLTsR..h+scThKEFu-Ll+KsL-sK+ALGLoa..opuNh.hsHlVTlWGA-YDssGNIcAlYITDSD.spAsIGhK+YslGVcuuGNltlsAc+lK........scstGAhlDGLaTLcpGQDpW	.................................................................................................................h......phpp.............................lWscGlss..Pt..p.pst.h..............apA.Pa.ss.......p.GaYDhsKs....hNup......Dp.LChAAsAuNMlHWWh-QNpppl-tYLpc...cptpl..htpp.thh-l+chlsoh....tsQps....SplFphF+s....hhuhpp.GhhsDhllDhFINGYh.ph..ptsss.....lp.....cs....Dp+GGhF.sVF....ppphLTs+..hhtts.hcchup.l+p.LppspslGLoa..phhsh...hsHllslWGA-a..D.sp.GplcA..lYlTDSD..p.......pt.....p.....lGhK+YhlshsssGp..tls.pphp........ppshGu.l.hlaTlphGps.W......................................................	1	7	11	13
+8861	PF09029	Preseq_ALAS		5-aminolevulinate synthase presequence	Mistry J, Sammut SJ	anon	pdb_1h7d	Domain	The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import [1].	20.70	20.70	21.30	22.40	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.79	0.72	-4.05	2	196	2009-01-15 18:05:59	2006-08-04 12:34:46	5	6	50	2	81	167	0	83.20	29	19.56	CHANGED	hlAhAhllRpCPhLupsPpshLt+suKo..hLh.htRCPl............LuTthPThpQ...KsTpsGs-psuhA.S+CPFhhsEhtcRcutlVp+Au.ElpEDVpphps	.....................................hlp.pCPhLspsspshltpshts..hl.hhtpCPh....................................................h..sst......st.....p.p........................tt..t..s..s....sp.pt..........s..hA..spCPFh.u.phtt.tstlh.cAu.ElQEDVpthp...............................................................................	0	7	12	32
+8862	PF09030	Creb_binding		Creb binding	Mistry J, Sammut SJ	anon	pdb_1kbh	Domain	The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery [1].	21.10	21.10	21.60	24.50	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.57	0.72	-3.84	4	148	2009-01-15 18:05:59	2006-08-04 12:48:14	5	14	46	7	70	100	0	105.30	55	4.94	CHANGED	..ssQWsQusLPQ...hpsuhPRPVhp.t.AQtuss...GPR.susQss.....tuI..uPsALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYsAsQPt.	..................................................s.W.t...Qus.lP..Q..Q........h.....sG....M...s.RPs..M.....u.Q..t.u.s..........uP.....p....ss.s...Qs.s....................tuh....u.sALQ-LLRTL+SPSS.PpQQQQVLNIL+SNPQLMAAFI..KQ.RsAKYs.usp.Pt..........	0	11	19	36
+8864	PF09032	Siah-Interact_N		Siah interacting protein, N terminal 	Mistry J, Sammut SJ	anon	pdb_1ysm	Domain	The N terminal domain of Siah interacting protein (SIP) adopts a helical hairpin structure with a hydrophobic core stabilised by a classic knobs-and-holes arrangement of side chains contributed by the two amphipathic helices. Little is known about this domain's function, except that it is crucial for interactions with Siah. It has also been hypothesised that SIP can dimerise through this N terminal domain [1].	21.30	21.30	21.30	21.40	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.83	0.72	-3.92	10	147	2009-01-15 18:05:59	2006-08-04 12:59:19	6	6	107	6	89	136	0	69.90	32	31.30	CHANGED	hsphlcpLptDL-El+pLlEpApRpRVpDlLppEh+KlEsElppppp....QcpQ..ppppEspcPou.hsssspsYTVKI	..........ppLppDL-El+sLLppApRpRV+-hLosEhp+lEsEltpt.h.p......p...tp.......p........................................................	0	23	36	61
+8865	PF09033	DFF-C		DNA Fragmentation factor 45kDa, C terminal domain	Mistry J, Sammut SJ	anon	pdb_1iyr	Domain	The C terminal domain of DNA Fragmentation factor 45kDa (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4). The main function of this domain is the inhibition of DFF40 by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFF40, the C-terminal region of DFF45 is also important for the DFF40-specific folding chaperone activity, as demonstrated by the ability of DFF45 to refold DFF40 [1].	25.00	25.00	39.80	39.30	23.20	22.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.00	0.71	-4.41	5	60	2009-01-15 18:05:59	2006-08-04 12:59:53	5	2	35	2	30	53	0	163.20	61	53.64	CHANGED	DGGTAWluRES..MEsD-sD.suGsD..+WKNLAcQLKEDLSSIILMSEEDLQsLIDVPsuELAusLshSppKVQuLQsTLQRVLDRREEERQSKQLLELYL+AlEKEGsh..+pQEscAsLu-E.DuVDoGh...sElsScsshuSpILhlLK-KsuPELSLSoQDLEhVsK	............................DGGTAWloQES..h-.s.DEsDouuGl...KWKNlARQ.LK-DLSSIILLSEEDLQsLlDlPCuDLApELsQSssplQsLQpTLQQVLDpREEsRQSKQLLpLYLpALEKEGulLSKppES...cA..u.hu.-EhDAVDo.Gh..spEsuSclsLsSplLssLKEKsAPELSLSSQDLElVs..........	0	2	4	11
+8866	PF09034	TRADD_N		TRADD, N-terminal domain	Mistry J, Sammut SJ	anon	pdb_1f3v	Domain	The N terminal domain of 'Tumour necrosis factor receptor type 1 associated death domain protein' (TRADD) folds into an alpha-beta sandwich with a four-stranded beta sheet and six alpha helices, each forming one layer of the structure. The domain allows docking of TRADD onto 'tumour necrosis factor receptor-associated factor' (TRAF): the binding is at the beta-sandwich domain, away from the coiled-coil domain. Binding ensures the recruitment of cIAPs to the signaling complex, which may be important for direct caspase-8 inhibition and the immediate suppression of apoptosis at the apical point of the cascade [1].	25.00	25.00	96.60	95.50	20.00	18.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.55	0.72	-4.07	6	45	2009-01-15 18:05:59	2006-08-04 13:05:06	5	2	37	2	25	42	0	110.40	57	37.13	CHANGED	-Su.Guh-uhEILKlHcuDP.LhVpLKFsuhssCpRFLpuYtpGALppuLpp+hsphLAl..cuLtlpTpLKAGscpLDthLsD.EpCLpaIptpQP-RLRD-ElAELEppLps	...-Su.GS.-slphLKIHcSDPQLIVQLRFCGcpsCsRFLcuYREGALRsuLQppLusuLA...pul.sLpLEL+AGAEcLDshLsDEERCLpsIhtppPDRLRDEEluELE-tL+s...........	0	1	3	10
+8867	PF09035	Tn916-Xis		Excisionase from transposon Tn916	Mistry J, Sammut SJ	anon	pdb_1y6u	Domain	The phage-encoded excisionase protein Tn916-Xis adopts a winged-helix structure that consists of a three-stranded anti-parallel beta-sheet that packs against a helix-turn-helix (HTH) motif and a third C-terminal alpha-helix. It is encoded for by Tn916, which also codes for the integrase Tn916-Int. The protein interacts with DNA by the insertion of helix alpha-2 into the major groove and the contact of the hairpin that connects strands beta-2 and beta-3 with the adjacent phosphodiester backbone and/or minor groove. Tn916-Xis stimulates phage excision and inhibits viral integration by stabilising distorted DNA structures [1].	22.90	22.90	22.90	22.90	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.25	0.72	-3.88	8	457	2012-10-04 14:01:12	2006-08-04 13:11:25	5	1	293	1	23	251	24	66.20	52	93.39	CHANGED	MN+.-..VPIWEKhoLTIEEAAcYasIGpNKLRpLs.cNPsscFVLalGo+hhIKRKcFEcaI-shssl	.................MppsD..lPIWE+YTLTIEEASKYFRIGENKLR+LAE..E..Nc..sAsW...l..IhNGN..RIQIKRKQFEK.hIDsLcsI.............	0	13	18	19
+8868	PF09036	Bcr-Abl_Oligo		Bcr-Abl oncoprotein oligomerisation domain	Mistry J, Sammut SJ	anon	pdb_1k1f	Domain	The Bcr-Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein [1].	20.90	20.90	21.10	32.00	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.81	0.72	-4.02	4	67	2009-09-11 10:35:23	2006-08-04 13:43:33	5	10	25	8	23	63	0	72.20	81	8.04	CHANGED	hVpPluFAEAW+AQFP-..u-PPhM-LRShGD........lEQEL-+C+uSIRRLEpEVN+ERFRMIYLQTLLAKERKSYD+QRWGF+R	..MV-PVGFsEAW+AQFPD..SEPP+MELR..SVGD........IEQELERCKASIRRLEQEVNpERFRMIYLQTLLAKEKKSYDRQRWGFRR.......	1	2	5	15
+8869	PF09037	Sulphotransf		Stf0 sulphotransferase	Mistry J, Sammut SJ	anon	pdb_1tex	Domain	Members of this family are essential for the biosynthesis of sulpholipid-1 in prokaryotes. They adopt a structure that belongs to the sulphotransferase superfamily, consisting of a single domain with a core four-stranded parallel beta-sheet flanked by alpha-helices [1].	20.70	20.70	20.70	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.47	0.70	-4.88	13	172	2012-10-05 12:31:09	2006-08-04 13:59:44	5	5	158	4	52	155	31	228.40	33	80.83	CHANGED	uYllCuosRSGSTLLsclLpuTGsAGpPppFFp........pss.hppWhtths.........shp.t.s-hthscsahptslptG+ussGVaGh+LMhpphshlhppLspL.PshsuDshR..lccsaG.p.shalHLpRcDpVuQAVShhRApQotlW+..ttsDusc.tR................tspYDssuIsphlphLccpEpuWpsWFtppsl-PlcIsY-sLsssPptslsslLptLGl-sphAsthsPslp+.ADppSc-WscRYRpD	.................................................................................................YllhuotRSGSTLLsc.LpuTG....ss....GpPpEaFp........................ssp..ccWhtthp................shp...s.ps-ht..s.s.tah.ptlh..stG.p.osNGlaGs.KL....Mh.sQhshl.p+.h...t..tl.ss...hs.........s..cshc..hlc.cl.h.G..p.tshhlHlpR.DlVsQAVShh......RA...hQ.......T.plW+.......sp.s.....Dspccsp....................shYcs......s.....sIu+hlp.tLcs.p-psWc.sWFs.p.cs.Ic.P...lcl.sY.s.L...h.c..s....s...s..h..lusVL-tlG...-..s..p.h..A.s..........tP...hlc+Qu...sppocEWspRa+t-................................................................................	0	10	31	42
+8870	PF09038	53-BP1_Tudor		Tumour suppressor p53-binding protein-1 Tudor	Mistry J, Sammut SJ	anon	pdb_1xni	Domain	Members of this family consist of ten beta-strands and a carboxy-terminal alpha-helix. The amino-terminal five beta-strands and the C-terminal five beta-strands adopt folds that are identical to each other. This domain is essential for the recruitment of proteins to double stranded breaks in DNA, which is mediated by interaction with methylated Lys 79 of histone H3 [1].	20.50	20.50	20.80	21.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.49	0.71	-4.29	3	89	2012-10-02 16:56:36	2006-08-04 14:11:33	5	3	51	16	40	84	2	117.20	74	7.46	CHANGED	GSSFVGLRVVAKWSSNGYFYSGKIT+DAGuGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHKKESpELYYSIEKDGQRKWYKRMAVILSLEQGNRLREQYGLGP	......GsSFVGLRVVAKWS.SNGYFYSGKITR.D.VGAGKYKLLFDDGYEC.....DVLGKDILLC...DPIPL.DT..E..V...TA.L.S.ED...EYFSAGV...V.KG..HR.K.E..S..GELYYS.IE.KE.GQRK.W..YKRMAVILSLEQGNRLREQYGLGP......................	0	7	9	23
+8871	PF09039	HTH_Tnp_Mu_2	Mu_I-gamma;	Mu DNA binding, I gamma subdomain	Mistry J, Sammut SJ	anon	pdb_2ezh	Domain	Members of this family are responsible for binding the DNA attachment sites at each end of the Mu genome. They adopt a secondary structure comprising a four helix bundle tightly packed around a hydrophobic core consisting of aliphatic and aromatic amino acid residues. Helices 1 and 2 are oriented antiparallel to each other. Helix 3 crosses helices 1 and 2 at angles of 60 and 120 degrees, respectively. Excluding the C-terminal helix 4, the fold of the I-gamma subdomain is remarkably similar to that of the homeodomain family of helix-turn-helix DNA-binding proteins, although their amino acid sequences are completely unrelated [1].	20.50	20.50	20.50	20.50	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.27	0.72	-4.32	6	131	2012-10-04 14:01:12	2006-08-04 14:14:54	6	14	112	4	25	141	1	106.80	35	17.57	CHANGED	hapVpshscsDWhPhLlst....sttcppsphu.Is-cAWtaFpuDYLR.EKPohssCYcRLcpAAp-pGW.sIPShuohpR+h.pplPcsplVhsREGpauLp+LhPsQpRo	.................................pVpthscsDWhssLlst....tss+ps.s+h..u.chsp-AW.p.F.hpuD.YLR.E...+Ps..aspCYcRLc...ts..Accp..G..W...s.....IPShpohpRRl..pplscs...h...hVhtRE.G-cALhc.hhPuQpRo...........	0	9	18	22
+8872	PF09040	H-K_ATPase_N		Gastric H+/K+-ATPase, N terminal domain	Mistry J, Sammut SJ	anon	pdb_1iwc	Domain	Members of this family adopt an alpha-helical conformation under hydrophobic conditions. The domain contains tyrosine residues, phosphorylation of which regulates the function of the ATPase. Additionally, the domain also interacts with various structural proteins, including the spectrin-binding domain of ankyrin III [1].	25.00	25.00	46.20	45.50	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-8.12	0.72	-3.85	5	35	2009-01-15 18:05:59	2006-08-04 14:31:05	6	6	21	2	19	36	0	41.00	88	4.36	CHANGED	GKAENYELYSVELGPGPGGDMAAKMS.KKKAGGGGGKKKEKL	..GKAENYELYSVELG.PGPGGDMAAKMS.KKK.AGGGGGK+KEKL......	0	1	1	2
+8873	PF09041	Aurora-A_bind		Aurora-A binding 	Mistry J, Sammut SJ	anon	pdb_1ol5	Domain	The Aurora-A binding domain binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1 [1].	20.20	20.20	21.60	23.00	19.50	17.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.46	0.72	-4.21	6	51	2009-01-15 18:05:59	2006-08-04 14:31:21	5	3	31	3	24	49	0	63.60	57	8.93	CHANGED	MSpspsoYSaDAPosFINFSSLc--.DhcNhDSWFDcpANLENh.sspctluclhQspsshpKstLQp	......MSQspoSYSaDAPocFINFoSLc-EtDspNlDSWFEEKANLENKh.ucNGhutlaQuKTsLRKsslpp.................	0	2	3	7
+8874	PF09042	Titin_Z		Titin Z	Mistry J, Sammut SJ	anon	pdb_1h8b	Domain	The titin Z domain, that recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly [1].	21.50	21.50	28.40	21.50	19.80	21.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.92	0.72	-4.36	13	282	2009-01-15 18:05:59	2006-08-04 14:33:34	6	47	33	1	104	290	0	41.60	41	1.23	CHANGED	pEplR+Es...........EK.sAVspVVlAssKA+ppEslscspEphus+pEQ	..............pEpl+KEs..........................................................-K.sAVspVVlAssK.A+cpE.h.+spEthss+p-Q..............	0	6	7	19
+8875	PF09043	Lys-AminoMut_A		D-Lysine 5,6-aminomutase alpha subunit	Mistry J, Sammut SJ	anon	pdb_1xrs	Domain	Members of his family are involved in the 1,2 rearrangement of the terminal amino group of DL-lysine and of L-beta-lysine, using adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate as cofactors. The structure is predominantly a PLP-binding TIM barrel domain, with several additional alpha-helices and beta-strands at the N and C termini. These helices and strands form an intertwined accessory clamp structure that wraps around the sides of the TIM barrel and extends up toward the Ado ligand of the Cbl cofactor, providing most of the interactions observed between the protein and the Ado ligand of the Cbl, suggesting that its role is mainly in stabilising AdoCbl in the precatalytic resting state [1].	25.00	25.00	70.20	70.10	17.50	17.30	hmmbuild  -o /dev/null HMM SEED	509	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.65	0.70	-6.38	8	226	2009-01-15 18:05:59	2006-08-04 14:41:35	6	3	199	25	54	150	6	435.60	50	68.49	CHANGED	LsLDhshV-+ARstA+cIAtssQcFI-pHTTVoVERTlsRLLGIDGVDspsVPLPNlVVDHlK-pssLspGAAhaluNAMlpTGpoPQEIAEuVAsGELDLpphPhp-ptcI+tshpslAptsV-+I+uNR+pRE-hlcph.G-tssPaLYVIVATGNIYEDVVQApAAARQGADVIAVIRoTuQSLLDYVPaGATTEGFGGTYATQENFRIMR+ALDEVGpElGRYIRLCNYCSGLCMPEIAAMGALERLDhMLNDALYGILFRDINMpRTLlDQaFSRlINGaAGIIINTGEDNYLTTADAhEcAHTVLASQhINEQFALhAGLP-EQMGLGHAFEM-P-LENGFLaELAQApMsREIFPKAPLKYMPPTKaMTGNIFKGHlQDAhFNlVolhTsQpIHLLGMLTEAIHTPFhpDRhLuIENAKYIFNNh+clusEIpFKcGGhIppRApEVLcKAhsLLEpIEpcGLFpuIE+GhFGsV+RPhDGGKGLsGVlpKstsYaNPFl-LM	.................................................................................................................................................................................cYhcph.ss.p.s.sPhlhs....lAoGch.-DlcphRhAAhpGADhIhVIRTTGQShlDhl.EG.TsEGhGGs.hTpcphRh.RKAhD.lp-.EVGR.IphpsYsSGlshPElAlhhA.EGlsshhpDs.YslLaRsINhhRoaVDtt.u+plhAhAsIh..sGtcNh.sTA.c.t.h.csh.p.l....hVpchlNphaulhsGhPc-.IGLups.....sPss.sphhh-LsaAlhlR-LFs-h.h+h..sT+YhpuslhcuhhpcslssLlohLTutcIQ.shhPsEuhssPWhpspshulposK.sasuhcGlt-.lphpc-G.lschsR-lh-+AlshLpE.h..cs.s.G.......hFsAlEcGhFsD...........IsRstpGGhu.usVsERDsDYhsPsh-..th....	0	31	42	52
+8876	PF09044	Kp4		Kp4	Mistry J, Sammut SJ	anon	pdb_1kpt	Domain	Members of this fungal family of toxins specifically inhibit voltage-gated calcium channels in mammalian cells. They adopt an alpha/beta-sandwich structure, comprising a five-stranded antiparallel beta-sheet with two antiparallel alpha-helices lying at approximately 45 degrees to these strands [1].	25.00	25.00	26.30	26.20	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.86	0.71	-4.32	2	55	2009-01-15 18:05:59	2006-08-04 15:01:32	5	2	26	2	49	54	0	118.20	34	83.92	CHANGED	.hLhhshh.ssstpLGINCRGSupC..hhsst.hh.hhRs.puhss.sphassGE+hApVs.....ssssuhsAalQs.sssshushcuhtHh..lspHGC+VCGSsP.....usNsVscGpLThNYV.Nu	........................................h.h....hshh.h.ss..suALGINCRGSuhC..s...s....u.....s.....ss....t...h..hphhttl.pshss...s+passGpcIACss..........s....t..su.......lCAF...hQsh.s.u.s...sssshpu..ltph..............Lh-HGCptCGSlP...stssNsVspGpLThNhV...s.......	0	7	24	37
+8877	PF09045	L27_2		L27_2	Mistry J, Sammut SJ	anon	pdb_1y76	Domain	The L27_2 domain is a protein-protein interaction domain capable of organising scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes. L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer [1].	20.90	20.90	21.00	21.40	20.00	18.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.67	0.72	-4.43	3	113	2009-01-15 18:05:59	2006-08-04 15:14:15	5	14	40	6	50	114	0	57.80	61	3.30	CHANGED	DKpRALQAlERLQuKLKERGDVssEEKLSLL+SVLQSPLFsQILoLQpSlQQLKDQVN	....DKppsLQshERLQsKL+ERGDsupp-KLSlL+ssLQSPLFsQILoLQpSlpQLKcQls......	0	6	9	22
+8878	PF09046	AvrPtoB-E3_ubiq		AvrPtoB E3 ubiquitin ligase	Mistry J, Sammut SJ	anon	pdb_2fd4	Domain	The E3 ubiquitin ligase domain found in the bacterial protein AvrPtoB inhibits immunity-associated programmed cell death (PCD) when translocated into plant cells, probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. The structure of this domain reveals a globular fold centred on a four-stranded beta-sheet that packs against two helices on one face and has three very extended loops connecting the elements of secondary structure, with remarkable homology to the RING-finger and U-box families of proteins involved in ubiquitin ligase complexes in eukaryotes [1].	25.00	25.00	107.80	107.10	24.60	18.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.58	0.71	-4.12	4	25	2009-01-15 18:05:59	2006-08-04 15:14:50	5	1	22	1	2	34	0	122.10	75	30.16	CHANGED	.tVVADIRAALc.IusQFsQLRTISKADAESp-.GF+DAAD.HPDDsTpCLFGEELSLSNPcQQVIGLAGpsTDhsQPYSQEuNKsLsFMDMKKLAQaLAuKPEHPMsR-pLsAcNIAKYAFRIVP	..............tVVsDI...RAALD.IusQFSQLRTISKADAESEELGF+DAAD.HP.DsATpCLFGEELSLSNPDQQVIGLAsNPTDpsQPYSQEsNKsLsFMDMKKLAQaLAsKPEHPhNRQpLDAcNIAKYAF+IVP	0	0	0	1
+8879	PF09047	MEF2_binding		MEF2 binding	Mistry J, Sammut SJ	anon	pdb_1n6j	Domain	The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription [1].	21.50	21.50	21.90	34.60	21.30	19.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.30	0.72	-4.31	2	61	2009-01-15 18:05:59	2006-08-04 15:27:42	5	3	32	1	25	48	0	34.20	90	2.02	CHANGED	TLLSPKGSISEETKQKLKssILSuQSAAss+K-oL	...TLLSPKGSISEETKQKLK......SAILSAQSAANVRKESL....	0	2	5	12
+8880	PF09048	Cro		Cro	Mistry J, Sammut SJ	anon	pdb_1d1m	Domain	Members of this family are involved in the repression of transcription by binding as a homodimer to palindromic DNA operator sites in phage lambda: they repress genes expressed in early phage development and are necessary for the late stage of lytic growth. These proteins have a secondary structure consisting of three alpha-helices and three beta-sheets, and dimerise through interactions between the two antiparallel beta-strands [1].	30.80	30.80	30.80	36.10	29.10	30.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.74	0.72	-4.33	5	146	2012-10-04 14:01:12	2006-08-04 15:37:13	5	1	126	17	5	68	1	59.00	66	89.33	CHANGED	Mp..RITLuDYVt+aGQAKAA+DLGVtQuAISKAL+AGRcIhVolssDGSVhAEEVRPFPS	....Mc.RITLpDYAhRFG.QsKTAKDLGVhQSAIsKAI+AGRcIFLTlpuDG.S.VhAEEV+PFPS......	0	0	1	4
+8881	PF09049	SNN_transmemb		Stannin transmembrane	Mistry J, Sammut SJ	anon	pdb_1zza	Domain	Members of this family consist of a single highly hydrophobic transmembrane helix that transverses the lipid bilayer at a 20 degree angle with respect to the membrane normal. They contain a conserved cysteine residue (Cys32) that, together with Cys34 found in the stannin unstructured linker domain, constitutes the putative trimethyltin-binding site that resides at the end of the transmembrane domain close to the lipid/solvent interface [1].	25.00	25.00	49.90	49.40	20.50	19.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.58	0.72	-4.25	3	39	2009-01-15 18:05:59	2006-08-04 15:42:51	5	2	37	1	24	25	0	33.00	95	37.68	CHANGED	MSIMDHSPTTGVVTVIVILIAIAALGALILGCW	.MSIMDHSPTTGVVTVIVILIAIAALGALILGCW	0	1	3	8
+8882	PF09050	SNN_linker		Stannin unstructured linker	Mistry J, Sammut SJ	anon	pdb_1zza	Domain	Members of this family are unstructured, acting as connectors of the stannin helical domains. They contain a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade [1].	25.00	25.00	63.90	63.40	17.80	16.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.51	0.72	-6.97	0.72	-4.39	3	39	2009-01-15 18:05:59	2006-08-04 15:43:56	5	2	37	1	24	25	0	26.00	95	29.68	CHANGED	CYLRLQRISQSEDEESIVGEGETKEP	CYLRLQRISQSEDEESIVGDGETKEP	0	1	3	8
+8883	PF09051	SNN_cytoplasm		Stannin cytoplasmic	Mistry J, Sammut SJ	anon	pdb_1zza	Domain	Members of this family consist of a distorted cytoplasmic helix that is partially absorbed into the plane of the lipid bilayer with a tilt angle of approximately 80 degrees from the membrane normal. They interact with the surface of the lipid bilayer, and contribute to the initiation of the apoptotic cascade on binding of the unstructured linker domain to dimethyltin [1].	25.00	25.00	34.70	39.20	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.42	0.72	-6.91	0.72	-4.21	5	37	2009-01-15 18:05:59	2006-08-04 15:44:50	5	1	35	1	24	23	0	26.50	87	30.25	CHANGED	LLVQYSAKGP+VE+KTKL.TPNGTESH	LLVQYSAKGPCVERKAKL.TPNGPEVH....	0	1	3	8
+8884	PF09052	SipA		Salmonella invasion protein A	Mistry J, Sammut SJ	anon	pdb_2fm8	Domain	Salmonella invasion protein A is an actin-binding protein that contributes to host cytoskeletal rearrangements by stimulating actin polymerisation and counteracting F-actin destabilising proteins. Members of this family possess an all-helical fold consisting of eight alpha-helices arranged so that six long, amphipathic helices form a compact fold that surrounds a final, predominantly hydrophobic helix in the middle of the molecule [1].	25.00	25.00	50.80	50.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	674	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-13.09	0.70	-6.13	3	143	2009-01-15 18:05:59	2006-08-04 15:52:32	5	2	130	10	3	112	0	584.70	80	99.48	CHANGED	MlTussTQAPshLsussosouTpASsLuupLSDVR.SuoToLusctSlu-LESFsAsasQ+SLDsLFuuSs+ADsL+ElYoNSsNsYAKpEIhEFAsVapSLl+QsuLsPEAcKsLpKluAQYoApIIKDGLuEKSAFGPWos+TKKtaQLRpNLE++LA-IAppHTuGEApKLGscLlpsEVooFItSCIEscLGpoLDslTSppLTcLVDuAAtpAFEuLRppRpcLI-p+GFSVG+LARDL-TVAVlPpLLRsVLssI..sPuD+tP-psuhssPscPpPuuGPsPuGsGKsucPstIHYHIN..IcssN+ShDNR+asNpucoalssup...RHlDNSsH-NScpsAsssTotosD.LsRNGpSlLSssuSssutpHuLVsuVTp...........slsHSISGpVDssAssoA.E+VhNsou-ucDGtVhhutlGSDGLTTS.pEhsAlsS+ScsG+PLpuss+uVsD...........sL+PlhothsGsEsVKouTssSsDTstSGschpp.sAGpssssNSsTDusGsFoGl+FRsGshYhTlPTls.h+uht..F-AccclLsulRsALEPsuopPhsQRREF-uLRs-ILPSDTh+psslKs+soDuschscLs-.cA-TL+cslssHPthEK....L+ElApsLuREAsLo+lccsos.LLoslLD..GLpuDs-hRAuPs...hsuKPsssuVlpTlDGLH	................MQTEIKTQATNLAANLSAVRESATsTLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTpLlDtA.AAKAVcALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLRNVFAQI...PADKLPD......PKIPEPAAGPVPDG.GKKAEPTGINININ..IDSSNHSVDNSKHINNSRSHVDNSQ...RHIDNSNHDpSRKTIDNSRTFIDN.SQRpGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDlTAHATA.EAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKhDTLQSDoTVITGNK.....AGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMH..FsAREsFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCS....DIDKHPELKA.KM-TLKEVITHHPQKEK....LAEIALQFAREAGLTR.KGETDYVLSNVLD..GLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLH.....	0	1	1	2
+8885	PF09053	CagZ		CagZ	Mistry J, Sammut SJ	anon	pdb_1s2x	Domain	CagZ is a 23 kDa protein consisting of a single compact L-shaped domain, composed of seven alpha-helices that run antiparallel to each other. 70% of the residues are in alpha-helix conformation and no beta-sheet is present. CagZ is essential for the translocation of the pathogenic protein CagA into host cells [1].	25.00	25.00	134.40	134.30	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.42	0.71	-4.99	3	75	2009-01-15 18:05:59	2006-08-04 16:00:15	5	1	40	1	1	58	0	195.10	97	99.99	CHANGED	MELGFNETERQKILDSN+SLMGNANEVRDKFIQNYATSLKDSNDPQDFLRRVQELRINMQKNFISFDsYYNYLNNLVLASYNRCKQEKTFAESTIKNELTLGEFVAEISDNFNNFMCDEVARISDLVASYLPREYLPPFIDGNMMGVAFQILGIDDFGRKLNEIVQDIGTKYIILSKNKTYLTSLERAKLITQLKLNLE	MELGFNEAERQKILDSN+SLMGNANEVRDKFIQNYAoSLKDSNDPQDFLRRVQELRINMQKNFISFDAYYNYLNNLVLASYNRCKQEKTFAESTIKNELTLGEFVAEISDNFNNFMCDEVARISDLVASYLPREYLPPFIDGNMMGVAFQILGIDDFGRKLNEIVQDIGTKYIILSKNKTYLTSLERAKLITQLKLNLE.....	0	1	1	1
+8887	PF09055	Sod_Ni		Nickel-containing superoxide dismutase	Mistry J, Sammut SJ	anon	pdb_1t6i	Domain	Nickel containing superoxide dismutase (NiSOD) is a metalloenzyme containing a hexameric assembly of right-handed 4-helix bundles of up-down-up-down topology with an N-terminal His-Cys-X-X-Pro-Cys-Gly-X-Tyr motif that chelates the active site Ni ions. NiSOD catalyses the disproportionation of superoxide to peroxide and molecular oxygen through alternate oxidation and reduction of Ni, protecting cells from the toxic products of aerobic metabolism [1].	25.00	25.00	49.20	49.10	19.70	18.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.85	0.71	-3.76	25	144	2009-09-10 20:18:48	2006-08-04 16:03:13	6	4	139	81	73	148	532	126.20	43	79.80	CHANGED	ssspVpA.......HCDlPCGlYDPusARltu......olhphhcclp-lsst..........st.tsphsRhlshKEp+ApclKcclhllWoDYFKss+l-..........pYPcLH-lhapshhtuuts..KtslDhspApcLlstlsclschFWpoK	.............s.spVpA.......HCDlPCGVYDPApARIcAE.....oVcuhpcKhpu.css..............shhsRhlhIKEp+AchsK+cl.lLWoDYFKssHhE.............cYPcLHpLhpcshKhsuAu....KsssDsupupcLLshIscIscIFWcTK................................	0	32	54	68
+8888	PF09056	Phospholip_A2_3		Prokaryotic phospholipase A2	Mistry J, Sammut SJ	anon	pdb_1faz	Domain	The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [1].	26.10	26.10	26.10	26.50	26.00	25.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.86	0.72	-3.86	18	148	2009-01-15 18:05:59	2006-08-04 16:06:21	6	9	113	5	85	147	14	106.50	36	37.65	CHANGED	TDphlFuhslssFsssRssp..sPup.L..DWooDGCSpuP.......DsPhGF...sFtsuCpRHDFGYRNY+tQsRFo.ss+t+..IDssFhpDhhptC...sthssh...htssCctsApsYYpAVRtFG	..................................t.shsta.stRpsp...sst..h..sWooDsCSsu..P..........Dp....PhGa....sF...tsuCpRHDFG.......Y....RNa....+.....t.....t...s+....F....ot....ss+.p+..lDssFppDLhphC..........st.st.............tpssCcu.hAtsYYtAV+thG..........................	0	22	50	73
+8889	PF09057	Smac_DIABLO		Second Mitochondria-derived Activator of Caspases	Mistry J, Sammut SJ	anon	pdb_1g73	Domain	Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution [1].	25.00	25.00	29.90	27.90	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.43	0.70	-5.24	4	112	2009-01-15 18:05:59	2006-08-04 16:07:38	5	3	52	23	36	107	0	189.70	51	94.57	CHANGED	p+L.tuss.lL+aptslls..sus.+pRplphL.ssaRK.sloluVGsulCAVPhsQ+sE..sLSpEuLlRRAsSLVTDSusTFLSQTThALl-ulTpYsKAVaTLlSLp+pYpu.luKhsspEEsuIWQVIIGtRsEhps++cphh+aESsWMsAVsLSEhAAEAAYpoGADQAslss+splQlsQoQVEpl+plu+cAEhpLA-opsEElcRhhp............p.ulp-tE-lPEAYLRED	..........................................................................................................t....hpp.hh.hshsh.slCAlPht.Q....p.-..sLSp-uLhRRAsSLVTDSooTFLSQTThALI-AlTEYoKAVYTLlSLh+pYtuhLGKhsupEEDpVWQVIIGtRsEhos+ppEhh+hEooWhoAV.sLSEhAAEAAYpoGADQASlTs+splQlspsQVpcs+pLStcAEpKLAEspspEl..cphtp...............p...t..ttp.t-t..EAYLRED.............................	0	5	9	19
+8890	PF09058	L27_1		L27_1	Mistry J, Sammut SJ	anon	pdb_1rso	Domain	The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form specific heterotetrameric complexes, in which each domain contains three alpha-helices [1].	21.60	21.60	21.60	23.00	20.60	21.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.99	0.72	-4.09	4	147	2009-01-15 18:05:59	2006-08-04 16:10:09	5	21	76	3	67	170	0	59.10	57	8.95	CHANGED	MPV++pDspRALpLLE-YpS+LSpstDctLRouIERVIsIFpSsLFQALlDIQEFYElTLhD.ss	.......MPl++p.-spRALcLLE-Y+u+Lo.p.............spD+pLRpuIERVIsIFpSsLFQAL.l..DIQ..EFYElTLLDs.............	1	24	30	48
+8891	PF09059	TyeA		TyeA	Mistry J, Sammut SJ	anon	pdb_1xl3	Domain	Members of this family are composed of two pairs of parallel alpha-helices, and interact with the bacterial protein YopN via hydrophobic residues located on the helices. Association of TyeA with the C terminus of YopN is accompanied by conformational changes in both polypeptides that create order out of disorder: the resulting structure then serves as an impediment to type III secretion of YopN [1].	21.10	21.10	21.40	21.50	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.67	0.72	-4.05	7	103	2009-01-15 18:05:59	2006-08-04 16:28:52	5	2	94	2	16	55	1	84.90	45	49.81	CHANGED	MAYssS-LMuDlIALVEcRWsusp-lpplssAhpLsssppplpFapEL++LlRhlPl-VFuDEEQRQNLlpAsQtALDtAI-pEEEE	.......MAYt.S-LMuDllALl-cRWlusp-lppLusuhsL..ssscpclpFap-L++lhRhlPlpVFuD-EQRQNLLpusQpAlD.AI-pEEEp....	0	7	9	11
+8892	PF09060	L27_N		L27_N	Mistry J, Sammut SJ	anon	pdb_1vf6	Domain	The L27_N domain plays a role in the biogenesis of tight junctions and in the establishment of cell polarity in epithelial cells. Each L27_N domain consists of three alpha-helices, the first two of which form an antiparallel coiled-coil. Two L27 domains come together to form a four-helical bundle with the antiparallel coiled-coils formed by the first two helices. The third helix of each domain forms another coiled-coil packing at one end of the four-helix bundle, creating a large hydrophobic interface: the hydrophobic interactions are the major force that drives heterodimer formation [1].	25.00	25.00	26.20	25.20	23.80	16.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.30	0.72	-4.16	4	63	2009-01-15 18:05:59	2006-08-04 16:39:47	5	6	39	8	31	52	0	48.90	65	7.50	CHANGED	ElE-LL.SLKplp+sLsDsQSQpDlELlhQLlppsDFQsAapIHNAVAt	...ElEDLhSSLKHIQHTLVDSQSQEDIuLLLQLVQNpDFQNAFKIHNAVo.s	0	2	5	13
+8894	PF09062	Endonuc_subdom		PI-PfuI Endonuclease subdomain	Sammut SJ	anon	pdb_1dq3	Domain	The endonuclease subdomain, found in the prokaryotic protein ribonucleotide reductase, assumes an alpha-beta-beta-alpha-beta-beta-alpha-alpha topology. The four stranded beta-sheet forms a saddle-shaped surface and assembles together through an interface made of alpha-helices. The presence of 14 basic residues on the surface of the beta-sheets suggests that this large groove may be involved in DNA binding [1].	24.40	24.40	24.70	38.40	23.20	24.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.50	0.72	-3.24	3	5	2012-10-03 01:41:40	2006-08-07 09:45:50	5	3	5	1	3	5	0	87.00	66	4.99	CHANGED	PDGEDYEFIFDYWLAGFIAGDGslDKY+SHVKGHEYlYDRLRIYDYphEThtIINDaLEKTFG++YSlQ+DRNIaYIDIKARsITSHYlELL-GI-NG	PDGEDYEFIFDYWLAGFIAGDGsFDKY+SHVKGHEYIYDRLRIYDYRlETFEIINDYLEKTFG++YSlQ+DRNIYYIDIKARsITSHYlKLL-GIDNG.......	0	1	1	2
+8895	PF09063	Phage_coat		Phage PP7 coat protein	Sammut SJ	anon	pdb_1dwn	Domain	Members of this family form the capsid of P. aeruginosa phage PP7. They adopt a secondary structure consisting of a six stranded beta sheet and an alpha helix [1].	25.00	25.00	25.30	283.20	24.00	17.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.78	0.71	-4.34	2	2	2009-01-15 18:05:59	2006-08-07 10:03:32	5	1	1	17	0	4	0	127.00	96	99.61	CHANGED	SKTIVLSVGEATRTLTEIQSTADRQIFEEKVGPLVGRLRLTASLRQNGAKTAYRVNLKLDQADVVDCSTSVCGELPKVRYTQVWSHDVTIVANSTEASRKSLYDLTKSLVspupsEDLVVNLVPLGR	SKTIVLSVGEATRTLTEIQSTADRQIFEEKVGPLVGRLRLTASLRQNGAKTAYRVNLKLDQADVVDCSTSVCGELPKVRYTQVWSHDVTIVANSTEASRKSLYDLTKSLVspupsEDLVVNLVPLGR	0	0	0	0
+8896	PF09064	Tme5_EGF_like		Thrombomodulin like fifth domain, EGF-like	Sammut SJ	anon	pdb_1dx5	Domain	Members of this family adopt a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with  thrombin, and subsequent activation of protein-C [1].	21.40	21.40	21.70	22.20	21.30	20.40	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-7.98	0.72	-4.34	6	46	2012-10-03 09:47:55	2006-08-07 11:18:30	5	20	34	0	27	41	0	34.80	55	7.17	CHANGED	MFCNQTsCPADCDPNosu..sChCPEGYILD-Gs...lC	..MFCNpTsCPA.DCDPNs.s...sCpCPEGYILD-G....hC........	1	1	4	11
+8897	PF09065	Haemadin		Haemadin	Sammut SJ	anon	pdb_1e0f	Domain	Members of this family adopt a secondary structure consisting of five short beta-strands (beta1-beta5), which are arranged in two antiparallel distorted sheets formed by strands beta1-beta4-beta5 and beta2-beta3 facing each other. This beta-sandwich is stabilised by six enclosed cysteines arranged in a [1-2, 3-5, 4-6] disulphide pairing resulting in a disulphide-rich hydrophobic core that is largely inaccessible to bulk solvent. The close proximity of disulfide bonds [3-5] and [4-6] organises haemadin into four distinct loops. The N-terminal segment of this domain binds to the active site of thrombin, inhibiting it [1].	25.00	25.00	26.00	71.90	23.30	15.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.30	0.72	-4.36	2	2	2009-01-15 18:05:59	2006-08-07 11:44:31	5	1	1	3	0	3	0	27.00	100	46.55	CHANGED	CDCGEKICLYGQSCNDGQCSGDPKPSS	CDCGEKICLYGQSCNDGQCSGDPKPSS	0	0	0	0
+8898	PF09066	B2-adapt-app_C		Beta2-adaptin appendage, C-terminal sub-domain	Sammut SJ	anon	pdb_1e42	Domain	Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [1].	21.10	21.10	21.40	21.10	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.29	0.71	-4.20	31	409	2009-01-15 18:05:59	2006-08-07 12:37:55	5	12	142	8	246	427	5	109.50	33	13.65	CHANGED	hs.D...uplspppF.phWpsl.spss..-hphphp...thss.pshpptLpspslahlApppsss...phhaaos+tssshhhlhElthpssssphplslKspss..chsthhhphhcpllp	..........................hsE-...Gph..-+phFltTW+...sl.Psps.......Ehpaphp.......s.hs..s....-.slps+L.pssNlaTIA+Rssps...pchhY....ShKh...s...s...Gl.hhLsELplp.s...us.s.s...h....p.....lolKscss.....Essphhhpsh-sll.....................................................	0	86	125	180
+8899	PF09067	EpoR_lig-bind		Erythropoietin receptor, ligand binding	Sammut SJ	anon	pdb_1eer	Domain	Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions [1].	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.61	0.72	-4.03	12	520	2012-10-03 16:25:20	2006-08-07 13:34:30	5	16	109	41	149	538	0	98.30	31	19.36	CHANGED	Spsu..hhstcsc.hpCFopshcDFTCFW-tspssshs...YshhYphps.-phppCslhppssssu...h.hChFsps.-splaV.hclpV.spssttspasR.lsV-	...........ss.......stcPchhpChS.phETFoCaWpsG...s..p..ss..l...s..os...apLhY...........p......p....c......s......p............p............h+E.C.P..-Ypsuus......so.......CaFspp..pTolWhsYplpVtsssphss..pc...................................	0	7	22	58
+8900	PF09068	EF-hand_2	efhand_1; EF_hand_2;	EF hand	Sammut SJ	anon	pdb_1eg3	Domain	Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (Pfam:PF00397), enhancing dystroglycan binding [1].	21.10	21.10	21.10	21.60	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.71	0.71	-4.06	30	673	2012-10-02 16:17:27	2006-08-07 14:46:03	6	51	101	2	277	608	0	121.10	42	11.54	CHANGED	chs-LhpsL..tDLNslRaSuYRTAhKLRtlQKthp.........LcLlsltslhcsFccpsLpp...............Dps.....lsVsclhssLoslY...................................................ppLspchsshs.sls............................................................................................................................hslDhhLNaLLNVYDssRsG+IpVLShKhulssLC	......................hppLatph....tcLsslR..hSsYRTAhKLRhlQKths..................................LcLlsl.ss.hEuhccpsLpp.......................Dps.....lsVsc.l.ssLoolY....................................................pLppchsshh.pls............................................................................................................................hslshhLNaLLssYD..........o..t..psG+lpVhShKsuLhoLC................................................................................................................	0	64	87	168
+8901	PF09069	EF-hand_3	efhand_2;	EF-hand	Sammut SJ	anon	pdb_1eg3	Domain	Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (Pfam:PF00397), enhancing dystroglycan binding [1].	21.70	21.70	21.70	28.00	20.20	21.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.96	0.72	-3.91	30	641	2012-10-02 16:17:27	2006-08-07 14:54:41	6	48	99	2	269	581	0	90.00	48	8.40	CHANGED	Lp-KaRYlFpQl.......u-ssGhhDpp+LulhL+-slplP+plGEssuFGsp..lEsSVRSCFpts....t.......................csclph.....spFL-WhphE..PQolVWLPlLHRlA	...........l.DKhRY.lFppl.......usosGhhspp+Ls.hL+-slplPptlhEssoFGh.....hEsSVRSCFpt........................................p.cIph.....stFLDhhhh-...P...Qs.h.......V.WLPlLHRlA...................................	0	59	79	159
+8902	PF09070	PFU		PFU (PLAA family ubiquitin binding)	Mistry J	anon	Pfam-B_5813 (release 20.0)	Domain	This domain is found N terminal to Pfam:PF08324 and binds to ubiquitin [1].	20.90	20.90	21.10	22.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.71	0.71	-4.08	39	348	2009-01-15 18:05:59	2006-08-07 15:24:39	6	21	290	7	246	358	3	111.50	39	15.52	CHANGED	ppsGp+EGpshhl+ss..GslEAYpWo..pupW.KIG-VVs..u....suss......stKthacG+cYDYVFDVDlp-GtPsLKLPYNhs-NPatsAp+Flp+p-..Ls.sYh-QVspFIhpN..TpGssls	................................................t.psGp+-GQsphl..+ps..splpAapWo......ptpW.plGsVVs..u..........sstp........utKhhapGc-YDYV..FsVDlp...-....G..tP...slKLPYNh...u-sPatsApcFlpcNc..Ls.s.......YlDQVspFIhpNTpu.t..s............	0	91	141	207
+8903	PF09071	Alpha-amyl_C		Alpha-amylase, C terminal	Sammut SJ	anon	pdb_1eh9	Domain	Members of this family, which are found in the prokaryotic protein glycosyltrehalose trehalohydrolase, assume a gamma-crystallin-type fold with a five-stranded anti-parallel beta-sheet that packs against the C-terminal side of a beta-alpha barrel. This domain is common to family 13 glycosidases and typically contains a five to ten strand beta-sheet, however its precise fold varies [1].	20.80	20.80	22.40	59.80	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.95	0.72	-4.22	5	18	2009-01-15 18:05:59	2006-08-07 15:32:08	5	3	18	8	4	16	0	66.80	58	12.17	CHANGED	CcR+lEVcsG-NWLTlptcKlhslauFScSVIplKYoGsLLlSS.sSFP++IscuK.h+l-KGFGlYK	.CNRKLoVENGNaWLTVKGNGYLlVYVFSpSlIEMKYRGTLVLSSNNSFPSQIsEsK.Y+L-KGFALYK.	1	1	1	3
+8904	PF09072	TMA7		Translation machinery associated TMA7	Mistry J, Wood V	anon	manual	Family	TMA7 plays a role in protein translation. Deletions of the TMA7 gene results in altered protein synthesis rates [1].	18.80	18.80	20.80	20.70	18.70	17.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.03	0.72	-3.51	24	302	2009-01-15 18:05:59	2006-08-07 15:37:21	5	6	232	0	204	302	0	61.00	54	81.09	CHANGED	uuRpGGKtKPLKAPKKppp-hDE-DlAFKpKQ+--pKAhKthtsKAtttGPLssu..GIKKSGKK	.............puRpGGKtK.PLKtPKKppK.E.h........DE-Dh...AFKpKQK--pKAhcEhtsKA.t.tKGPLs.sG..GIKKS.GKK...............	0	57	97	157
+8905	PF09073	BUD22		BUD22	Mistry J, Wood V	anon	manual	Family	BUD22 has been shown in yeast to be a nuclear protein involved in bud-site selection.  It plays a role in positioning the proximal bud pole signal [1]. More recently it has been shown to be involved in ribosome biogenesis [2,3].	37.00	37.00	37.00	37.00	36.60	36.40	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-12.79	0.70	-5.41	26	209	2009-01-15 18:05:59	2006-08-07 16:03:09	5	4	184	0	156	214	2	308.60	23	71.15	CHANGED	Khcpuhpp...LppsLKpApth-hpKLh++.+th.tt.......................ssshscltcplphh+ph...shpphscthlhppLhK........................s.thh.stthhp...hhp..cKsttspssc.htp...t.t..sslsupLhssK.l+shhsslhpslctlhGhpsptttppcptpsppsppspppp............................ttppppppttcup-ssspcpstc-.....................ssss-tcpps-p...............thspaDsh.....lssusp-pp...........................................t.scspspscscppspcsSpp.tss.s.ppt..sspKKtKtpp...........tpph.LPpL.hsGYaSGu-s-spp.t............-hsspth..............pRKNRhGQ+ARptlWEKKYGppApHlpc.....cpE+ptpcppt.........Rptta-t..Rputp.......................tucsss.ttspspthts+.ppstpstppp.................LHPSWpAK+tAc-pt.t..sApFpGKKlsFD	..............................................................................................................................................................................h......h..........................................................................h.t.h.t.....h...h..h...h......t.......t....tt.tt.....................................................................t.............t......................................t................................tt..................sttptt...................................................................................p...tt.......t...................t..........................p...c.............................................lPpL....suahpsspst..t..........t.t................................cKNRhGQpARptlhEpKaGttApHltp........t...t...t.................................pp.thc...+psth......................................................tttttt.tt..ppttthttp..t.tt.s.ttttp.p......t................LHPSWcAp++tKEpt.p.......s...sFp..G....KKIsFD................................................	0	41	78	126
+8906	PF09074	Mer2		Mer2	Mistry J, Wood V	anon	manual	Family	Mer2 (Rec107) forms part of a complex  that is required for meiotic double strand DNA break formation.  Mer2 increases in abundance and is phosphorylated during the prophase phase of cell division [1]. Blocking double strand break formation results in delayed dephosphorylation and dissociation of Mer2 from the chromosome [1].	27.70	27.50	27.70	27.90	27.40	27.10	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.38	0.71	-4.37	6	18	2009-12-23 15:34:04	2006-08-07 16:30:48	5	1	18	0	11	19	0	183.10	29	57.19	CHANGED	us.shuopssscshputcs.........slsEuD+QIlEWAGKLELESl-L+E.pu-pLhsllsppsppLhhsstplsphL.ppp.....tuppcslcslh.slusplsNpLp-shpulppphcshpt..pp.htt...............h.sspchs+hsu.pshcIIpp.-.stt.ch.Kuhcshp-hlhNhusQLEshptlhlSlS+pL+s....LpsRpsshc	...................................o.sssshpph.s.........slpEuDKQILEWAGKLELESh-LRE.poscLlplLpcNScpLhpshpphsphL.p.c.....tupptslcphhcsLssplpspLccs.psh.spscphps..ppthtp................l.hspclp+hss....+Ih+php.s+Qpch.KShcsTQchlaNlssQLEchpcVLlShS+-hcs....LpsRQssLc..........................................................................................	0	1	7	11
+8907	PF09075	STb_secrete		Heat-stable enterotoxin B, secretory	Sammut SJ	anon	pdb_1ehs	Domain	Members of this family assume a helical secondary structure, with two alpha helices forming a disulphide crosslinked alpha-helical hairpin. The disulphide bonds are crucial for the toxic activity of the protein, and are required for maintenance of the tertiary structure, and subsequent interaction with the particulate form of guanylate cyclase, increasing cyclic GMP levels within the host intestinal epithelial cells [1].	25.00	25.00	128.80	128.50	18.70	17.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.40	0.72	-4.11	2	6	2009-01-15 18:05:59	2006-08-08 09:28:43	5	1	3	1	0	5	0	48.00	98	71.46	CHANGED	STQSNKKDLCEpYRQIAKESCKhGFLGVRDGTAGACFGAQIMVAAKGC	STQSNKKDLCEHYRQIAKESCKKGFLGVRDGTAGACFGAQIMVAAKGC	0	0	0	0
+8908	PF09076	Crystall_2	Sklp_toxin;	Beta/Gamma crystallin	Sammut SJ, Eberhardt R	anon	pdb_1f53	Domain	Members of this family assume a beta-gamma-crystallin fold [1,2], wherein nine beta-strands are connected by loop, and are separated into two sheets, each sheet forming the Greek key motif. The two Greek key motifs face each other in the global topology. The three-dimensional structure of the molecule is a 'sandwich'-shaped beta-barrel structure: hydrophobic side-chains are packed in the large interface area of the beta-sheets. In Streptomyces killer toxin-like protein domain confers a cytocidal effect to the toxin, causing cell death in both budding and fission yeasts, and morphological changes in yeasts and filamentous fungi [1].  This family also includes chitin-biding antifungal proteins [2-3].	25.00	25.00	25.30	45.10	22.60	20.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.35	0.72	-4.21	10	18	2012-10-01 23:14:22	2006-08-08 10:32:47	5	1	15	2	5	22	0	71.90	35	65.99	CHANGED	cIcsHtssspuh.CaANuGshshuh.s......Vs+ISTGNNhVsaphssGs.lpht+hpslTa.NhsshVssh-lh	.......plhoHhssppSh.CaANtGphsFuhhs......VD+ISTGNNhlpapsssGsp..lphs..+apslTaPN+PstVssIcIh........	0	1	5	5
+8909	PF09077	Phage-MuB_C		Mu B transposition protein, C terminal 	Sammut SJ	anon	pdb_1f6v	Domain	The C terminal domain of the B transposition protein from Bacteriophage Mu comprises four alpha-helices arranged in a loosely packed bundle, where helix alpha1 runs parallel to alpha3, and anti-parallel to helices alpha2 and alpha4. The domain allows for non-specific binding of Mu to double-stranded DNA, allowing for integration into the bacterial genome, and mediates dimerisation of the protein [1].	25.00	25.00	26.70	26.70	22.70	20.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.49	0.72	-4.31	15	110	2009-01-15 18:05:59	2006-08-08 10:54:26	6	3	100	1	15	94	1	77.00	46	25.15	CHANGED	SRlAK+suIpKoKKuDVpAlApAWsl..ps-cthplhppIupK.PGuLRlLo+TLRLAuMsAcGcs.s.ls.chlptAap-L	.SRlA+pptlpKsKKuDVpAIAcAWsl..ss-pEhplhppIupK..PGALRlLo+TL+LAshsApGcGts.lspcalptAa+El....	0	4	9	14
+8910	PF09078	CheY-binding		CheY binding	Sammut SJ	anon	pdb_1ffg	Domain	Members of this family adopt a secondary structure consisting of an open-face beta/alpha sandwich, with four antiparallel beta-strands and two alpha-helices. They bind to a corresponding domain on CheY, with subsequent phosphorylation of the CheY Asp57 residue, and activation of CheY, which then affects flagellar rotation [1].	21.10	21.10	21.30	30.50	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.87	0.72	-3.96	30	622	2009-01-15 18:05:59	2006-08-08 13:08:00	6	8	596	13	79	360	5	64.90	65	9.76	CHANGED	LRIpLoplcsp-h-LLpEELGNLGslsssp+uu-oLsshLsoslupDDIsAVhCFVI-s-QIshp	...RIlLSRLKAsEVDLLEEELGpLsTLTDVVKGADSLSAhLsGslAEDDIsAVLCFVIEADQIsFE..........	0	6	28	52
+8911	PF09079	Cdc6_C		CDC6, C terminal 	Sammut SJ	anon	pdb_1fnn	Domain	The C terminal domain of CDC6 assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate Cdc6 activity [1].	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.61	0.72	-4.26	83	705	2009-01-15 18:05:59	2006-08-08 13:37:42	6	7	285	10	384	699	139	80.40	22	15.43	CHANGED	LhAllhhtppsp...p.hssuclachYpplscp.hsh..cslop.cclpshls-LchhGllpsch.spG..p.tG+ppcl..pLshs..pplhcs.....l	........................Lhullhhhcppt.....cphshsc....lachYppl.Ccp..hsh..pslsp.pchhshl.scLc.thGll.phpp......ptpuphpcl....pLp.hs...cplhtsl........................	0	83	216	312
+8912	PF09080	K-cyclin_vir_C		K cyclin, C terminal	Sammut SJ	anon	pdb_1g3n	Domain	Members of this family adopt a secondary structure consisting of a five alpha-helix cyclin fold. Interaction with cyclin dependent kinases (CDKs) at a PSTAIRE sequence motif within the catalytic cleft of CDK results in the regulation of CDK activity [1].	25.30	25.30	25.70	134.40	24.10	25.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.45	0.72	-3.84	2	10	2009-01-15 18:05:59	2006-08-08 14:06:09	5	1	6	2	0	9	0	103.90	69	40.57	CHANGED	AVLsTDshu.hLhK.hhspppL.hhHppVsp.lpKAlVsPtTGuLPsSlluAA.CALhs.usshP.ss.......pLAphlGsssusLtAAsEplhTolp-FD..RI	AVLATDVTSFLLLKLLGGSQHLDFWHHEVNTLITKALVDPKTGSLPASIISAAGCALLVPANVIPQDTHSGGVVPQLASILGCDVSVLQAAVEQILTSVSDFDL.RI...	0	0	0	0
+8913	PF09081	DUF1921		Domain of unknown function (DUF1921)	Sammut SJ	anon	pdb_1gcy	Domain	This domain, which is found in a set of prokaryotic amylases, has no known function [1].	25.00	25.00	29.30	89.70	24.80	17.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.29	0.72	-4.00	5	11	2009-09-11 11:07:02	2006-08-08 14:32:33	5	2	11	9	3	20	0	50.80	71	9.46	CHANGED	oGFSGLVATlSGSsQpLVhALDSNLSSPuQVASGSFSpAlNpDNGplRIWR	SGYSGLVATVoGSQQTLVVALNSNLSNPGQVASGSFSEAVNsSNGQVRVWR	0	1	2	3
+8914	PF09082	DUF1922		Domain of unknown function (DUF1922)	Sammut SJ	anon	pdb_1gh9	Domain	Members of this family consist of a beta-sheet region followed by an alpha-helix and an unstructured C-terminus. The beta-sheet region contains a CXCX...XCXC sequence with Cys residues located in two proximal loops and pointing towards each other. This precise function of this set of bacterial proteins is, as yet, unknown [1].	20.70	20.70	21.80	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.39	0.72	-3.91	3	19	2009-01-15 18:05:59	2006-08-08 14:42:03	5	1	19	1	16	17	1	66.50	36	78.59	CHANGED	YlIFRCDCGRVLYSKEGsKTRKCVCGKTlNVKcRRIFK+A-opEEASEsVQcMQEEIYGuocF+sAS..E	..............YhIFRC.c.CGRhlYu+-sspT++C.sCG+sl+lKppRIht+scstcEAuphVp+lQpphhGtstFpps..t.......	0	2	13	14
+8915	PF09083	DUF1923		Domain of unknown function (DUF1923)	Sammut SJ	anon	pdb_1gjw	Domain	Members of this family are found in maltosyltransferases, and adopt a secondary structure consisting of eight antiparallel beta-strands, which form an open-sided 'jelly roll' Greek key beta-barrel. Their exact function is, as yet, unknown [1].	19.20	19.20	20.20	98.00	18.30	19.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.15	0.72	-4.49	2	7	2009-01-15 18:05:59	2006-08-08 15:55:14	5	1	6	2	1	5	0	64.10	86	10.04	CHANGED	GKFENLTTKDLVMYSYEKNGQKIVIAANVGKEPKEITGGRVWNGKWSDEEKVVLKPLEFALVVQ	GKFENLTTcDLVMYSYE+NGQKIllAANVGKEPKEITGGRVWNGK.WSDEEKVVLKPL-FsLVVQ	0	1	1	1
+8916	PF09084	NMT1		NMT1/THI5 like	Mistry J, Wood V	anon	Pfam-B_2797 (release 20.0)	Family	This family contains the NMT1 and THI5 proteins.  These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine [1][2][3].  They are regulated by thiamine [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.17	0.70	-4.75	60	7206	2012-10-03 15:33:52	2006-08-08 16:24:59	6	87	2898	13	2338	13311	2793	196.00	17	56.48	CHANGED	NssHsslalAppKGaFc-pGL-V.cIhps.sssssssphVusGpsDh.ulsht.plh..hs+u.pGhPlhslusllppshsulhshccss.Ip..s.pDLcGK+lG..hss.ssh..pcshlpshlppsGh..s.sclphlss.shsh...ulhsGplDsshhshtsh-hlp..hc..........hcGh...chphhhhp-hGss.sahshlllsscshlpp.ps-hl+pFlcAsp+GhpashscPc-A	................................................................................................................................................................t.......t.....t.......u.......l.....p.....l...p.h..h..........ss....s....s......t.........h.....p.....h..l.....t..s.G..p..hD.....h.....u..........h.........s.......t......t.....................s....h..h.........hs.........t.........s.......p............G.........h.........s..........l..........h.........h........l................u.........s...............h........h.......t.......p.........s...........s.........t........s...........l........l.........s......h............p............s..........s.......s...Ip..............oh.....t...........D..........L.........+.........G.........K.........+....l..u............h..st....uss.............s.p...h......h....h...t.......t.....h........L....p.......p...t...G.l.....................s.....s......c.......l.....p.....h........l..........t.........h.............s............s............s............s.......t................h.................s......u.......l..t...s......G..p..l...D..A..h...h........h.........s............h......h..t.......................................................t.s.........h........h...h.................t.....p..............s.........................................................h......h.....h....s....p....t.p....h....hp.....p...p..............t.......h...t...t...h...h.t..sh....pu.h.t..h...t...................................................................................................................................	0	641	1405	1915
+8917	PF09085	Adhes-Ig_like		Adhesion molecule, immunoglobulin-like	Sammut SJ	anon	pdb_1gsm	Domain	Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues [1].	25.00	25.00	26.30	65.10	18.50	17.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.35	0.72	-4.21	5	43	2012-10-03 02:52:13	2006-08-08 16:37:59	5	4	21	2	9	34	0	108.90	71	32.38	CHANGED	AFPDQLTVSPEALVPGpDpEVACTAHNVTPAcP-uLShSLLLG-QELEGuQALsPEVpE...EPQEuE.DPLFQVTpRWLLPuLGTPuPPALHCQVTMpLPGLpLSHR+uIPVL	.AFPDQLTVSPsALVPG.D.EVACTAHcVTPsDPNuLSFSLLLGsQELEGAQAL.sPEVcE...E..PQp-E.Ds.LFRVTcRWRLPPLGTPsPPALaCQATMRLPGLELSHRQAIPh......	0	1	1	2
+8918	PF09086	DUF1924		Domain of unknown function (DUF1924)	Sammut SJ	anon	pdb_1gu2	Domain	This domain is found in a set of bacterial proteins, including Cytochrome c-type protein. It is functionally uncharacterised.	21.00	21.00	21.00	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.42	0.72	-3.94	17	99	2012-10-03 10:02:11	2006-08-08 16:50:24	6	2	90	17	41	102	18	95.10	45	66.68	CHANGED	hpssuh.sshsusRGptLappct......cphuCsSCHssssppsGpHspTGK.IpPhAPusNPcRaoDsAKVEKWFpRNCppVlGRtCTspEKGDhlsaL	........h.tstuhsshsAtRGpthatscp.....s.cphSCuoCHssss.....TpsGpHspTGKsIcPhAPusNPcRaTDsAKlEKWFpRNCssVluR-CTstEKuDhLsaL............................	0	9	27	32
+8919	PF09087	Cyc-maltodext_N		Cyclomaltodextrinase, N-terminal	Sammut SJ	anon	pdb_1h3g	Domain	Members of this family assume a beta-sandwich structure composed of the eight antiparallel beta-strands. A ten residue linker is also present at the C-terminal end, which connects the N terminal domain to a distal domain in the protein. This domain participates in oligomerisation of the protein, wherein the N-terminal domain of one subunit contacts the active centre of the other subunit, and is also required for binding of cyclodextrin to substrate [1].	25.00	25.00	29.60	28.80	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.01	0.72	-4.06	28	194	2009-01-15 18:05:59	2006-08-09 09:13:25	6	4	178	12	55	197	92	87.20	39	14.09	CHANGED	+lEPs.WWsGMpNscLQLMlaGcsIus....hplslsh.sGVplpslp+.s-NPNYLFlsL-ls.pAcsGshslshpps............cpphphsYpLKpRcp	....+l-Ps.WWsGM+NP.pLQLhlY..G..csIus....spVolsh.sGVplpsls+.h-sPNYLhlhLsls..pApPGphslshp.ps............cpphshsYpLKtRp............	0	22	42	52
+8920	PF09088	MIF4G_like		MIF4G like	Sammut SJ	anon	pdb_1h6k	Domain	Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices [1].	19.80	19.80	20.10	20.10	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.23	0.71	-4.86	9	328	2012-10-11 20:01:01	2006-08-09 09:53:49	6	9	258	11	235	329	0	159.30	35	20.77	CHANGED	PsssolsuhlhR-hlhDhIshhcaNRp-sA+hLlsLchahs.tTFs..sss.spL...........hsPspSoWplEDlhVEslhuplFpLPsP.hp.lYYpSlLhEhC+huPsslAPslGRulRhlYpplso..hDhEhhcRFlDWFSaHLSNFsFpWpWpEWlsDl.pLssh..HP+hsFl+plIcKElRLSahpRI+poLP-	.......................................................................................................................................................................s.tsph.h-.hhVEslFuplFpL.........PsP.......a....h.......laYtolLlElC.......Kh.......t..P....u.....u...ls..s....lupAhchLYpp.l-s...............hsh..ph.hpRalsWFSaHLSNFpFp......W...p.Wp-Wsssl......p.h.st..................pP+htFlppllcKplRL.Sat.p.RIpphlP...................	0	75	123	197
+8921	PF09089	gp12-short_mid		Phage short tail fibre protein gp12, middle domain	Sammut SJ	anon	pdb_1h6w	Domain	Members of this family adopt a right-handed triple-stranded beta-helix fold, and are found in the middle of the phage short tail fibre protein gp12 [1].	25.00	25.00	25.50	26.00	21.90	18.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.92	0.72	-4.03	2	20	2009-01-15 18:05:59	2006-08-09 11:06:17	5	2	18	1	0	24	0	76.70	59	14.83	CHANGED	TGtTLNGRGuTsSMRGVVKLTTpAGststGDuSuALAWNADVIppRGGQhI.GoLpl.DphT.ANGhhshsGhh+.sst.l	....TGtTLNGRGuTTSMRGVVKLTTTAG.tstGDuSoALAWNADVIsTRGGQTINGoLNl.ssLT.ANGhhshsGhhp.sst.l............	0	0	0	0
+8922	PF09090	MIF4G_like_2		MIF4G like	Sammut SJ	anon	pdb_1h6k	Domain	Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices [1].	21.00	21.00	22.80	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.58	0.70	-5.15	17	319	2012-10-11 20:01:01	2006-08-09 11:16:47	6	8	264	11	230	316	4	252.90	22	31.81	CHANGED	Fpa......pp-shPhpptuppllshh+p+.ts..sc-lhpllppltp.sss.t.....s..hhtlslhlpsllplGS+ShSHshshlp+hpppL+tl........................hpspppcthllculhcaWpspsQhhhlllDphlphpllsstullsWhh.spph....sphhscshsaEhlppslpchttpht....t................................................c-.sst..............................h.ppLtpthsctppllthhhpphl.ll............sp....psspphtphstpW...ahthhGhlcshltca	........................................................apa........tppshPh..tshupplhshl+pK.ss....scEl.sllp...pl..p.spstt.................s...hplclhlpslLplGSKShSHshu.slp+..a+phlpp..l......................................................spsp..ps.php...llpslhchWp.spsQhhhlllDKh.lphpIlsstuVlpWl...F...ssph...............spths.......chalaEhlpsolpKhsp+lhpltpch...p...........................................................................................p-.s.t...........................................phpthpcpLppt.s.-tpslhhhhh..p.phl.lh...................spt...hpspt.th.pph.tp.W........ah.hhth.pthhh..................................................................................	0	79	126	191
+8924	PF09092	Lyase_N		Lyase, N terminal	Sammut SJ	anon	pdb_1hn0	Domain	Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a jelly-roll fold topology consisting of a two-layered bent beta-sheet sandwich with one short alpha-helix. The convex beta sheet is composed of five antiparallel strands, whilst the concave beta-sheet contains five antiparallel beta-strands with a loop between two consecutive strands folding back onto the concave surface. This domain is required for binding of the protein to long glycosaminoglycan chains [1].	26.00	26.00	26.30	30.20	25.60	25.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.22	0.71	-4.64	8	133	2012-10-03 19:46:52	2006-08-09 13:18:47	6	3	88	3	22	127	1	177.80	36	17.68	CHANGED	uhhpSphh-Fs.GsQlP-hhpsuuGSpLSLSus+YhhGpQSLcWcWpsGSohslc+PlsL.pccsASKsaGhpu...lohWIYNEpPVDshhph-LGpch.hsSGsPcAuFcl+lNFoGWRushVShppD..h-Gcch-G.....................Kush-SlRhhAPhtAPpGplaIDRVhhuhc.DARhQhoD.QV...+sR	....................................h.hsh.Ep..p.lPsthpsustSpLolSsp+YKpGppSLcWsa.p.sGus.Ls.lccs.lph...pc.........s...ss.uKshuhpu..............hphWIY.NEpP.c.ct.l.p.F-Fhcs.......Gcss...suFphplNFoGWRusaVsacpD..MpG..ptt-G.......................pMsplRlhAP.......ss.pGp..lalD+lhhuhc.DsRhQhuD.Ql.h......................	0	8	19	19
+8925	PF09093	Lyase_catalyt		Lyase, catalytic	Sammut SJ	anon	pdb_1hn0	Domain	Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a helical structure, with fifteen alpha-helices which are at least two turns long and several short helical turns. The bulk of the domain is formed by ten alpha-helices forming five hairpin-like pairs and arranged into an incomplete toroid, the (alpha/alpha)5 fold. Additionally, two long and two short alpha-helices at the N terminus of the domain wrap around the toroid. At the C-terminal end of the toroid there is one additional short alpha-helix. This domain is required for degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucoronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups [1].	22.80	22.80	23.60	23.00	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.11	0.70	-5.56	4	140	2009-01-15 18:05:59	2006-08-09 13:19:05	6	4	89	3	25	131	2	351.20	36	35.10	CHANGED	P-lpl...loP.psRphcslttl-p..hhp-hls.hhts.t.ps.shpppIsph+pca-thsIshpusG.thoGsPlhss+pp.hapsEhh.s.sKshhssh.lh.ttYss..................+pp.KppaLshaDahhDQGaAhGSuhsThHHaGYpsRthYhusaLM+DsLpEps+hsphhsTLRWas.shppoh.scPstsst.hDpapThhht+lh.lLhhsDs.c+lphlpohSRWlstuL.pssPGhtGulKsDGsuFHHcGsY.PuYuhsuhcsAuphIYLhpcTsFuloEpuppslKcshluhp.YsN.hchuhulSGRHPhss..uppls.uYAhhAluucss.....hD+phAusYLRLhcpssops.tt..a	.................................................................phth....s.lss.ptt-hthh-p..hhpshl......ts..t...t.h..pphpphctpasthpIphp..sG.ploGpsIh...ts.+pp....haps...hhsshscphho...ph.shhssYtsLh.pluhhapps.s.....+pphtchalhhhcalhDQGashGSuhsshHH.aGYss.RthYhuhaLM+c.hLc...cps....hh..pts.csLhW..Ys.shppphp...p.....s....s..s..pupslDhaNThhpt+l.uslhhhs..Ds.....s..c+lphL+uFucWlshul.pssPGhhGGhKsDGosFHHpssY.PuYuhsuhss.AuphlYhLsGTs..Ftlo-pA+pslKpAhLs.....h.....c......h.YsN..hp.h.sluloGRHPh.s........psp.l.h.tsFthh.ALuGsPsst.pphDptLAAsYL+Lspssps.t...................................	1	10	22	22
+8926	PF09094	DUF1925		Domain of unknown function (DUF1925)	Sammut SJ	anon	pdb_1k1x	Domain	Members of this family, which are found in a set of prokaryotic transferases, adopt an immunoglobulin/albumin-binding domain-like fold, with a bundle of three alpha-helices. Their function is, as yet, unknown [1].	21.10	21.10	21.40	26.60	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.92	0.72	-3.99	15	86	2009-01-15 18:05:59	2006-08-09 14:08:33	6	2	86	5	57	89	15	78.20	46	11.65	CHANGED	GhW+NFhsKYsEoNhMHKRMLtVSc+lpsh.......tsp......ApctLa+AQCNDAYWHGlFGGlYLPHLRcAlYcsLI+A-shL	......GhW+NFhsKYPESNhMHKRMLhlSpplpph........tptp.......spctLa+uQsNDsYWH.G.lFGGlYLPHLRcAlacplIcAEp..h...	0	27	41	47
+8927	PF09095	DUF1926		Domain of unknown function (DUF1926)	Sammut SJ	anon	pdb_1k1x	Domain	Members of this family, which are found in a set of prokaryotic transferases, adopt a beta-sandwich fold, in which two layers of anti-parallel beta-sheets are arranged in a nearly parallel fashion. The exact function of this family is, as yet, unknown, however it has been proposed that they may play a role in transglycosylation reactions [1].	19.60	19.60	21.50	21.10	17.40	19.50	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.56	0.70	-5.18	21	118	2009-12-15 10:48:00	2006-08-09 14:08:46	6	5	105	5	74	118	24	224.80	21	38.21	CHANGED	DhDhDGpcElhlpscsh.shlcsstGGslhElss+..sttaNasssLsRphEtYHctl..........ppptpslsohH-hsphhtc.hcccltaDhahRshhhD+hhpsstsL-shhpsp...p.uDh...sa.ht..tt.....lphhtct.h...hth.hplpKshplps...sslplpYplp.........pshshhaulElN..........LA...................lpuhtcshs..tscplplpD.ahhsclplc..hspssplathPlpTlSQSEtGa-hlhQulshhhhasl....ptphphplph	......................DhDhDGhcEhhhpspph.hhlpst.GGplhEh-hh..ttthNhhsshsRp.EhYaphh.........................t..t.t.....h..hcp....h.......tthh.D.h.+h.hhDphh..thshpph.tsp.......t.....a..h......ttt........hhh.t...h..........hplpKphphpp...ss..lplpYplp.......t..s...hphhausEhN.........lu..........................tth..p..t.........tspthth.-..hh.hph.lp...h.st.hphhhhPh.olo.po-.tGh-hh.Quhthhhhh.h......t.........h.........................	0	35	58	64
+8928	PF09096	Phage-tail_2		Baseplate structural protein, domain 2	Sammut SJ	anon	pdb_1k28	Domain	Members of this family adopt a beta barrel structure with a Greek key topology, which is topologically similar to the FMN-binding split barrel. They are structural component of the viral baseplate, predominantly found in the structural protein gp27 [1].	25.00	25.00	59.50	58.10	23.30	19.40	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.14	0.71	-4.62	6	29	2012-10-01 22:58:23	2006-08-09 14:44:45	5	3	27	3	0	28	0	166.00	58	42.44	CHANGED	hlspEPIshlVsEPRLlGQaIp.l-p.lsFDFEWLTKANsaTRsPacNsThYAHSFlDKphs+IlTG-GpNulslSRSGAYuDhTYRNGaEEusRLhThuQYDuYApspTaGNFsLTPGhKIpFaDpKNQF+sEFaVDEVIHElSpppSlTpLYMFsNSptlp.....cVKNE	..hlsQEPhshlVGEPpLIGQalQplchPlAaDFpWLTKuNt+sRsPhcNsTlYAHSFlDpphs+IosGcGpNSIlVSRSGuYS-hTYRNGaEEA.RLhTMAQYDGYAcCpohGNFsLTPGhKI.FhDsKNQF+s-FYVDEVIHElSNNsSlTpLYMFTNuppLc.....cVKNE..........	0	0	0	0
+8929	PF09097	Phage-tail_1		Baseplate structural protein, domain 1	Sammut SJ	anon	pdb_1k28	Domain	Members of this family adopt a beta barrel structure with a Greek key topology, which is topologically similar to the FMN-binding split barrel. They are structural component of the viral baseplate, predominantly found in the structural protein gp27 [1].	18.90	18.90	19.10	120.10	17.30	16.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.12	0.71	-4.73	5	31	2012-10-01 22:58:23	2006-08-09 14:44:55	5	3	30	3	0	31	0	194.80	57	49.04	CHANGED	QRsGYPNVSIKLYQsYDAWLENRFIELAATFlTLTMRDGLh.GlNEGLLQFYDuKNLHTKLsG-EIIQlSLKTANT.EpTaNRIYGIKHhuVoVDpKGDNIITFQLGSlHplcNLKFSRMFTNsAVsSVsEMIGsIYpDpPLLsPsIsuINshVPpsPWVsoINcYhcFVRcaGQoVEoE+FVaVWEDh-GIsIuDa	....QRsGaPNlSIKLY-sYDAWh-NRFlELAAThTTLTMRDuLY.GpNEGlLQFYDuKNlHTKMsGcpIIQISlpNANo.pplpoRIYGsKHauVSVDsKGDNIIsIpLusIHplcNLKFuRsFFssAsEolpEMlsVIYpD+sLLsPsINuINsYVPslPWsuohcsYhsaVRElGhuVtS-cFVFVWEDh.GIshhDY...	1	0	0	0
+8930	PF09098	Dehyd-heme_bind		Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding	Sammut SJ, Eberhardt R	anon	pdb_1pby	Domain	Members of this family are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase. They have a predominantly alpha-helical structure and can be divided into two subdomains, each binding a haem C group via a conserved CXXCH motif [1,2].	25.20	25.20	25.30	25.40	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.12	0.71	-4.81	11	50	2012-10-03 10:02:11	2006-08-09 17:04:58	5	5	42	4	19	60	5	135.40	38	33.92	CHANGED	tsGppllpppChuCHsspsss..thuRISpQRKTPEGW.MTlsRMphhHGlplos--RpslVKYLADpQGLAPuETcuhRYllERcPNshEpscstphophCuRCHStARluLQRRTspEWc+LlpFHLGQaPolEYQAhuRDR-WaslAhs-llPhLAcpYPh-osuW	...t.pGppllpspChuCHssptps....shsRIuppRKTPEG.W.MolsRMphhHGl.plos--+pslV+YLADppGLuPsEstshpYhh-+p.ss.-.ph.......s..hsphCuRCHShARhhLQRRstpEWppLlpaHluQaPohEhQA.uRDRpWh.lA.tphhs.Lucpashtp...........................	0	3	13	16
+8931	PF09099	Qn_am_d_aIII	DUF1927;	Quinohemoprotein amine dehydrogenase, alpha subunit domain III	Sammut SJ, Eberhardt R	anon	pdb_1pby	Domain	Members of this family, which are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase, adopt an immunoglobulin-like beta-sandwich fold, with seven strands arranged into two beta sheets; the fold is possibly related to the immunoglobulin and/or fibronectin type III superfamilies. The precise function of this domain has not, as yet, been defined [1,2].	21.20	21.20	21.20	21.20	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.36	0.72	-3.66	14	45	2012-10-03 16:25:20	2006-08-09 17:07:52	5	8	39	4	18	55	11	81.00	32	14.49	CHANGED	pspllAVpPshl+sGsc.sclslsGsuL.....suclsLusGlcVscVlppossplslcV+ssucApsG.RsVulGutp.ussLsVYs	...........tspllAVpPshl+AGsc.oplolsGouL.....sucssL...u.s..G...lcVscllp..posspltVcl+suA-ApsG.+plulGshp.sssLsVYp..........	0	7	14	15
+8932	PF09100	Qn_am_d_aIV	DUF1928;	Quinohemoprotein amine dehydrogenase, alpha subunit domain IV	Sammut SJ, Eberhardt R	anon	pdb_1pby	Domain	Members of this family, which are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase, adopt an immunoglobulin-like beta-sandwich fold, with seven strands arranged into two beta sheets; the fold is possibly related to the immunoglobulin and/or fibronectin type III superfamilies. The precise function of this domain has not, as yet, been defined [1,2].	25.00	25.00	131.60	130.70	19.20	15.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.84	0.71	-4.47	12	36	2009-01-15 18:05:59	2006-08-09 17:08:39	5	4	31	4	13	43	3	130.40	52	25.03	CHANGED	VKVsPsaulARlGGsGG..shPKh.upF-AhuahsGsDGKsGTsDDlclGslPAoWul-sFDEpAtcDpDs+YAGphpss.GlFsPusAGPNPtR+huTNNsGNLKVlATVc-u....uctlou-uphlVTV...QRassPPl	.VKVsPsauIARIGGsGu..s.hPKVtupFEA.AassGsDGcPtTtDDlRlGhlPAoWolEsFsEpAtcDcDl+aAGphpus.GlFsPusAGPNPcR+htTNNAGNLKVlATlsDG....up.loGEuHhIVTV...QRWNsPPl..	0	2	9	10
+8933	PF09101	Exotox-A_bind		Exotoxin A binding	Sammut SJ	anon	pdb_1ikp	Domain	Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for binding of the toxin to the alpha-2-macroglobulin receptor, with subsequent internalisation into endosomes. The domain adopts a thirteen-strand antiparallel beta jelly roll topology, which belongs to the Concanavalin A-like lectins/glucanases fold superfamily [1].	20.50	20.50	20.60	20.80	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.79	0.70	-5.27	2	97	2009-01-15 18:05:59	2006-08-10 09:38:45	5	7	59	4	3	94	0	187.30	43	28.60	CHANGED	E-thslasECtpsCsLs.csGh..pS+hSl.ssslhD...pGVLaYSMslpstpsslK.t.Dpu.SIho.G..hTlRhpt.........GV......p.NtshpYSYsRp.cGpaulNWLVPIGc-pPusIKl.lcELsttppl.chs.lYoI-hssphLt..KhttssoF.Vpt.EpN.....lAISasuVShhhAQtpspRcKRWucWtoGhsLChLsPhDulYNYlsQQpCsLsDsW.Gt.YcslAGsP....sKpsl-.KP..lppRlHF	.......................................CsLs.c.Gh..pSphSl.s.slhD...pGVLaYSMslpstpsslh.t.spu.SIho.G..hTlRhpt.........GV......p.NtshpYSasRp.cupaslNWLVPIGc-pPusIKl.lcELsttppl.chs.lYoI-hssphLt..c.ttssoF.Vpt.EpN.....lAISaPuVShKhApppGpRHKRWu+WtoGL...AhCWhlPl.uIYNYIsQtpCshuDsWhGt.YcslAGsP....sKpsl................................	0	1	2	2
+8934	PF09102	Exotox-A_target		Exotoxin A, targeting	Sammut SJ	anon	pdb_1ikp	Domain	Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for transmembrane targeting of the toxin, as well as transmembrane translocation of the catalytic domain into the cytoplasmic compartment. A furin cleavage site is present within the domain: cleavage generates a 37 kDa carboxy-terminal fragment, which includes the enzymatic domain, which is then is translocated into the cytoplasm. The domain adopts a helical structure, with six alpha-helices forming a bundle [1].	21.60	21.60	22.60	208.90	21.30	16.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.89	0.71	-4.68	2	59	2009-01-15 18:05:59	2006-08-10 09:57:46	5	2	22	4	1	67	0	140.50	74	23.57	CHANGED	cGsuhuALsAHpsCtlPLEThsRpRpPRshpp..pCuY.sQplVuLalAsRl.asplDpVhp.sLsp.tst.....uDLtch.cppPt.sp.sLTlAtt..pcaVpptsG....pspAGAtuADllSLhCPsAstpC.AussD	..tNAMpALAAHRVCGVPLETLARSRKPRDLsDDLSCAYQAQNIVSLFVATRILFSHLDSVFTLNLDEQEPEVAERLSsLRpINENNPGMVTQVLTVARQIYNDYVTHHPGLTPEQTSAGAQAADILSLFCPDADKSCVASNND	1	1	1	1
+8935	PF09103	BRCA-2_OB1		BRCA2, oligonucleotide/oligosaccharide-binding, domain 1	Sammut SJ	anon	pdb_1iyj	Domain	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [1].	23.30	23.30	23.40	25.40	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.50	0.71	-4.40	19	188	2009-01-15 18:05:59	2006-08-10 11:08:30	5	33	140	3	119	199	1	125.00	36	6.93	CHANGED	Sul++IhEpDsssuphhVLhVSpl............................p.t.s.ttshlELoDGWYsl+utlD.sLpphlccG+lpl..GpKLh..........lpGAc...Lhu.scsssPL.E....sssslhLplshNuTRhAcWps..+LGhh+..hs	........................SAl++IhEpDssuupsh.VLCVSsIh.................................................................tpppsts.spp.sshlELTDGW.......Yul+Ap.LDs.sL....tphl...cp...G.....+..Lpl..GpKlh.....................lpGAc........Lhu.ss.csss.PL.E..................sspslhLplssNSTR.ApWts..+LGahtp..............................	0	65	79	100
+8936	PF09104	BRCA-2_OB3		BRCA2, oligonucleotide/oligosaccharide-binding, domain 3	Sammut SJ	anon	pdb_1iyj	Domain	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding [1].	21.10	21.10	21.20	23.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.84	0.71	-4.38	5	83	2009-09-11 15:20:08	2006-08-10 11:09:07	5	17	53	3	44	85	0	137.90	45	5.33	CHANGED	REsLcFo+LLDPuFQPPCSEVDlVGlVVSV..V+spGLAPlVYLSDEChNLLsVKFWsDLN....EDIlKP+VLIAASNLQWR.PEu+SsIPTLFAG-aSsFSASPKEsHFQE+FscM+pTlE..NIDoFYcEAEpKLlcLLsuNsPK	...............RcslpFscLh-PsFpPsCuEVDllGhVlSV.......s+p....t..GhuPhVYL.S....DEsaNL.LulKFWtDLs....EDIlKPpsLIAASNLQWR...s-op...Ssl..PoLaAGDhSsFSA.sPKEuHhQEsFschKsslc..Nls..hFhs-AEpKL.hclLptp....................	1	10	14	27
+8937	PF09105	SelB-wing_1		Elongation factor SelB, winged helix 	Sammut SJ	anon	pdb_1lva	Domain	Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding [1].	25.00	25.00	25.40	148.40	23.10	23.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-8.84	0.72	-4.31	2	2	2009-01-15 18:05:59	2006-08-10 11:45:38	5	1	2	3	1	5	0	61.00	100	9.62	CHANGED	GSPEKILAQIIQEHREGLDWQEAATRASLSLEETRKLLQSMAAAGQVTLLRVENDLYAIST	GSPEKILAQIIQEHREGLDWQEAATRASLSLEETRKLLQSMAAAGQVTLLRVENDLYAIST	0	1	1	1
+8938	PF09106	SelB-wing_2		Elongation factor SelB, winged helix 	Sammut SJ	anon	pdb_1lva	Domain	Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding [1].	21.50	21.50	21.60	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.64	0.72	-4.04	67	966	2009-01-15 18:05:59	2006-08-10 11:46:27	6	14	953	6	177	683	32	57.80	44	9.28	CHANGED	llstLspaHpcpP.c.Gls+-cL+...Rhst.ths....splaptllppLhppGplttptshl+L	......lL-sLAsYHEpHtDcsGsuRERLR......RhAlPht-.................-sLl...hhLI-chp-sGtIhsc+GWLHL.............................	0	66	113	151
+8939	PF09107	SelB-wing_3		Elongation factor SelB, winged helix 	Sammut SJ	anon	pdb_1lva	Domain	Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding [1].	22.20	22.20	22.60	22.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.40	0.72	-4.57	95	1262	2009-01-15 18:05:59	2006-08-10 11:47:24	6	13	1235	10	249	928	241	50.30	43	8.23	CHANGED	ltphhp..p..ssplssuphR-hl.GhoRKhulslLEahDctthT+RtG..-.pRhlp	.............tpl.p..c...sGuhssA-FRDtL....s.....luRKhAItlLEYFDRh.GaTRRcG...s.c+lLR.......	0	93	169	217
+8940	PF09108	Xol-1_N		Switch protein XOL-1, N-terminal	Sammut SJ	anon	pdb_1mg7	Domain	Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and six antiparallel beta sheets, in a beta-alpha-beta-beta-beta-alpha-beta-alpha-alpha-alpha-beta arrangement. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like [1].	25.00	25.00	25.00	32.40	18.90	24.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.02	0.71	-4.56	2	12	2012-10-03 01:04:38	2006-08-10 13:53:43	5	3	5	2	11	15	0	147.40	27	40.39	CHANGED	lc+Sps.Pl....Ep-sssNh.ssKlsu.APHsVchMsShhhAlN+.Chsps+s..spcP+SupEHhI.-hscphHsphphullRshlcpLcLppVYcIphhs.hD.sG+lu.hshLlAlW+s.............LKSh.psh.tpFt..........DshhS	.........p..ph.p..t......................tpphsu...APHVVpluss...sahAVN+hClVpupllpp+.PpssppH..hI.phstc.psp.phslltphlccLpL+.psYcIpIhsthDassphu...hhshLsAIWKShsh...........p....h........h...tp.................h.................	0	1	2	11
+8941	PF09109	Xol-1_GHMP-like		Switch protein XOL-1, GHMP-like	Sammut SJ	anon	pdb_1mg7	Domain	Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and seven antiparallel beta sheets, in a beta-alpha-beta-alpha-alpha-alpha-beta-beta-alpha-beta-beta-beta arrangement. The fold of this family is structurally similar to that found in the C-terminal domain of GHMP Kinase [1].	25.00	25.00	28.00	27.20	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.15	0.71	-4.21	2	10	2009-01-15 18:05:59	2006-08-10 13:54:42	5	2	5	2	9	12	0	170.80	24	43.23	CHANGED	VthlAE.................aDhVFVpTsLHs.caTPphF.sptpsKh...tFpp.c-pspaPD..hst.MshaScpRVtppshss..l.h.op.uLctl.ppcppl.GFElQQGGhLVsLKKssFhsDc..hIphhuhhlts-pppSlppl.FcLLc.G.tup.hp.s..+hh-.pp+sslplchKsVp	..........................pssphhshhu..................tF.cpaDllFV+TNLH......sScFcPp..h...s+..pps+s..cthpp....c-ssph.scs..lsthMhthScsRhspEs.h..s...hpphEpDCcsAlpphp.ppc.pp...l...cGFEVQQGGILllLKKssFhssc....LLcsIuhuItcpsp..t.ploplSFsLLpPutsu..p...........................h.................	0	1	2	9
+8942	PF09110	HAND		HAND	Sammut SJ	anon	pdb_1ofc	Domain	The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. The domain confers DNA and nucleosome binding properties to the protein [1].	21.00	21.00	21.20	21.20	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.36	0.71	-3.68	29	385	2009-01-15 18:05:59	2006-08-10 14:51:15	6	11	236	5	260	400	3	101.60	46	10.01	CHANGED	SlDsYYKDlLpsGspssp.......spsPRsPKphslpDaQFaPspLhcL.E+Ephaa+KplsYKsshp-sss............................cs.p-+cpcpchEQccI-NApPLTEEEpp.KpcLhpEG	.....................ulDsYa+-AL+...supsps...........PKsPRsPKQsslpDFQFFP.PRLhELhEKE..hhaa+KplGYKVsh.s.s.......................................phspttttpc.EQpcIDpApPLT-EE.pEK-cLlspG..............................................................................................................	0	70	132	206
+8943	PF09111	SLIDE		SLIDE	Sammut SJ	anon	pdb_1ofc	Domain	The SLIDE domain adopts a secondary structure comprising a main core of three alpha-helices. It has a role in DNA binding, contacting DNA target sites similar to c-Myb (Pfam:PF00249) repeats or homeodomains [1].	20.80	20.80	21.00	24.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.29	0.71	-4.37	36	454	2009-01-15 18:05:59	2006-08-10 14:52:14	5	18	282	5	306	466	4	115.10	47	11.41	CHANGED	a-KhlppIEpGEcKhp+hppppchLcpKlpphcsPhp-Lplp....Ys..ssp++sYo--EDRFlLshlt+hGh..t.sha-cl+ppI+psPhF+FDWFhpSRTspEluRRssTLlphlp+Ehp	.........-KhhtpIEcGEt+lp+ptphc+uLcpKlspY+.sPhppL+Ip..............Yu.....ssp......tKsYoEEEDRFLlsMLaK.hGh.-p-....slY-clRpsIRpuP.FRFDWFlKSRTshELpRRCsTLlshIE+E............	0	101	169	249
+8944	PF09112	N-glycanase_N	PngaseF_N;	Peptide-N-glycosidase F, N terminal	Sammut SJ	anon	pdb_1pgs	Domain	Members of this family adopt an eight-stranded antiparallel beta jelly roll configuration, with the beta strands arranged into two sheets. They are similar in topology to many viral capsid proteins, as well as lectins and several glucanases. The domain allows the protein to bind sugars and catalyses the complete removal of N-linked oligosaccharide chains from glycoproteins [1].	17.80	17.80	17.90	19.10	17.60	17.50	hmmbuild  --amino -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.36	0.71	-4.90	16	80	2009-01-15 18:05:59	2006-08-10 15:15:43	5	4	67	8	27	83	150	166.50	33	34.00	CHANGED	slsVF-ctplpFssssh.......tts...th.ttphhLpplpLPs..htcsh.slpLcls.tssG...Ds...WD+oGol..FVlPcssshph.s.htp...........................slELhRFhTPFtluphs....................psVsacpDlosLhPhLpG.cshlshahssWsttG.....ahsSlclch	............................pl.VF-pp.lpFssshh.......ttss.hphssGpllLKKlpLPs..hpcs.h.slplclsltSsG......Dt....WD+oGSs..FVlPcs.sshshhs.htps.tthP.hps.php..h.GllsstpY.sslELMRFhTPFGVupas..........h...lhh.pW.psV.appDlTcLhPlLc.....u.-salGlaIssWs...tcG.....ahsShclch......................................	5	10	22	26
+8945	PF09113	N-glycanase_C	PngaseF_C;	Peptide-N-glycosidase F, C terminal	Sammut SJ	anon	pdb_1pgs	Domain	Members of this family adopt an eight-stranded antiparallel beta jelly roll configuration, with the beta strands arranged into two sheets. They are similar in topology to many viral capsid proteins, as well as lectins and several glucanases. The domain allows the protein to bind sugars and catalyses the complete removal of N-linked oligosaccharide chains from glycoproteins [1].	25.00	25.00	42.90	37.50	17.10	16.80	hmmbuild  --amino -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.19	0.71	-4.49	23	91	2009-01-15 18:05:59	2006-08-10 15:17:00	5	6	75	8	36	95	190	148.10	34	28.22	CHANGED	psYssh....................t.shsh...sFslPsss+pscLhsllTGHG.......spssssEFs.psHplhVsGpps....hphhsht.sCAshth.sss....pGsWh...........................huRusWCPGpslpPhpl-lsshhssspthssslshtshhsGsp............uhhhhSuaLl	........................pYsph.hspc.slsh...sFslspss+sscLchlsTGHG.......GasGGDEFst+ppplhlDGppl....hsahPWRp-CuoaRpaNPu..........oGsWh.......................uSSDhSRSNWCPGsslsPphlslssltsGpHohslsIPtut.h-Gsp............saWhlSuhLl...............................	0	18	30	35
+8946	PF09114	MotA_activ		Transcription factor MotA, activation domain	Sammut SJ	anon	pdb_1bja	Domain	Members of this family of viral protein domains are implicated in transcriptional activation. They are almost completely alpha-helical, with five alpha-helices and a short, two-stranded, beta-ribbon. Four alpha helices (alpha1, alpha3, alpha4 and alpha5) are amphipathic and pack their hydrophobic surfaces around the central helix alpha2 [1].	26.10	26.10	27.10	26.50	25.70	26.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.21	0.72	-4.23	3	22	2012-10-04 14:01:12	2006-08-10 15:54:45	5	2	21	3	0	19	0	93.10	56	44.63	CHANGED	SKVTYIIKASNNA.LNEKTAsIhIpIAKKsFITAAEVREuVcsEhNsuVVNSNIGVLIKKGLVEKSGDGLIsTGEApDIIscAA-LaAQENAPELLK	..........SKlTYIIKASpss.LNEKTAuILIpIAKKsFITuuEVRE.lp.-husAVVNSNIGVLIKKGLlEKSGDG.LlhTuEupDIlppAAsLaApENAPEhL...........	0	0	0	0
+8947	PF09115	DNApol3-delta_C		DNA polymerase III, delta subunit, C terminal	Sammut SJ	anon	pdb_1a5t	Domain	Members of this family, which are predominantly found in prokaryotic DNA polymerase III, assume an alpha helical structure, with a core of five alpha helices, and an additional small helix. They are essential for the formation of the polymerase clamp loader [1].	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.43	0.71	-4.07	41	817	2009-01-15 18:05:59	2006-08-11 10:11:52	5	2	811	9	97	453	22	117.10	43	36.28	CHANGED	p.t.hppRpphhpshhpshpspsh..lpLlshls..ccps.tpLcWLtsLLhDAlKhphGlsp.hhhNtD.hshlpplupphssptLhpthpplhph+ppLhplsulNpELLLhchLlphpp.h...l	....................................t.s-pWptRcsLCQuL.h..ulp.osDh..huLL..sALN...HE..pAssRLaWLuoLLhDALKt+aGAup..lsNsDhsslVspLAspLSsu+Lpsllscls+hR-QLhsVoG..lNRELLlTDhLL+lEch..............	0	20	42	70
+8948	PF09116	gp45-slide_C		gp45 sliding clamp, C terminal	Sammut SJ	anon	pdb_1b77	Domain	Members of this family are essential for the interaction of the gp45 sliding clamp with the corresponding polymerase. They adopt a DNA clamp fold, consisting of two alpha helices and two beta sheets - the fold is duplicated and has internal pseudo two-fold symmetry [1].	25.00	25.00	25.80	33.30	22.00	24.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.34	0.71	-10.38	0.71	-4.09	9	69	2009-01-15 18:05:59	2006-08-11 11:03:52	5	2	67	21	1	60	670	110.60	33	49.59	CHANGED	sVhF-lcA-DhpQLh+sSpslplDslulssc-G..+IVlsuapph.Dus.spspaSlslu.-a-Gss.sFsFllphsNMKhhs...ucYKVhlhu.......chAupFputpss..YllAhEscSoasF	.....sVpFc..Lcu-cLppLh+supshplsslslsscsG....+lVlss.....cp.....spspspYSlp.l.G.-h-sss..FsFslphpNhKhls...GcYcVhlss.......ptsupFpup..s..hs..YhlALEsss............	0	1	1	1
+8949	PF09117	MiAMP1		MiAMP1	Sammut SJ	anon	pdb_1c01	Domain	MiAMP1 is a highly basic protein from the nut kernel of Macadamia integrifolia which inhibits the growth of several microbial plant pathogens in vitro while having no effect on mammalian or plant cells. It consists of eight beta-strands which are arranged in two Greek key motifs. These Greek key motifs then associate to form a Greek key beta-barrel [1].	21.80	21.80	22.80	22.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.82	0.72	-3.56	2	31	2012-10-01 23:14:22	2006-08-11 11:26:43	5	1	12	1	19	30	0	78.70	46	75.83	CHANGED	ShFTsWuGPGCNN+AtRYSKCGCSsItpp..GGY-F.YpGQTAAhYNpssCpGVApTRFuSSs.pACssFGWKShFIQC	..............SYFssWuGPGCNN.....chtRYS...sCGCoNluss.H.GGYcFsYQ.GQTAusYNsssCpGVspTRFS....s....os.QsCu..s.FGWpShFIQC...............................................................	0	0	16	19
+8950	PF09118	DUF1929		Domain of unknown function (DUF1929)	Sammut SJ	anon	pdb_1k3i	Domain	Members of this family adopt a secondary structure consisting of a bundle of seven, mostly antiparallel, beta-strands surrounding a hydrophobic core. The 7 strands are arranged in 2 sheets, in a Greek-key topology. Their precise function, has not, as yet, been defined, though they are mostly found in sugar-utilising enzymes, such as galactose oxidase [1].	25.00	25.00	27.80	27.60	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.47	0.72	-3.90	68	596	2009-01-15 18:05:59	2006-08-11 11:52:05	6	64	224	13	381	626	15	99.90	29	14.34	CHANGED	RPslss.s.....s........ssl....saGsshslss..........ss......shspssLl+sussTHuhshsQRhl.Lsh........tsst....ssp.hssshP..sss..s.lssPGaYMlFlls.sG....lPShuphVpl	........................................RPslss..s..s..........ssl..shG.s.s.hsls.hp...................ss..........shhpssLlpsuhsTHohsh.sQRhl.Lsh............................ssss......sts..hslshP..sss...slsPPGaYMLFlls.sG......lPS.h.u.phVpl........................	0	152	263	339
+8951	PF09119	SicP-binding		SicP binding	Sammut SJ	anon	pdb_1jyo	Domain	Members of this family bind the chaperone SicP, which is required both to maintain the stability of SptP, as well as to ensure the eventual secretion of the protein. The domain is found in the Salmonella effector protein SptP, which interacts with SicP chaperone dimers mainly through four regions of its chaperone-binding domain. The structure of the SptP-SicP complex contains four molecules of SicP, aligned in a linear fashion and arranged in two sets of tightly bound homodimers that bind two SptP molecules. The SicP homodimers do not interact with each other, but are held together by a molecular interface formed between two SptP molecules. Each SptP molecule is wrapped around by three SicP chaperones (two chaperones from one homodimer and a third one from the opposite homodimer pair) [1].	25.00	25.00	25.50	38.20	24.20	19.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.48	0.72	-4.28	3	136	2009-09-10 17:21:18	2006-08-11 13:28:16	5	3	135	2	4	70	0	81.50	68	14.40	CHANGED	A+EGFKEKLLoaLSHlPLLKNT-AVQ+YsEslRl-N++lLpVFLpALocRYGc-AApDAlDhuclssssPLTQRpl...VQITE	...APEKFSSKVLTWLGKMPLFKNTEVVQKHTENI+sQDQKILQTFLpALTEKYGETAVNsALLMSRIN.MN.KPLTQRLA...VQITE..	0	1	1	2
+8953	PF09121	Tower		Tower	Sammut SJ	anon	pdb_1mje	Domain	Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA [1].	25.00	25.00	25.10	48.10	24.80	23.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-8.14	0.72	-4.02	9	69	2009-01-15 18:05:59	2006-08-11 14:43:34	5	13	38	3	30	70	0	41.90	65	1.52	CHANGED	MEKpssGhhlFRNpRtEE+EAt+aupsQQKKLEsLFoKIQsE	MEKTsoGhYIFRNERtEEKEAsKaAEsQQKKLEALFsKIQsE.	0	4	6	13
+8954	PF09122	DUF1930		Domain of unknown function (DUF1930)	Sammut SJ	anon	pdb_1okg	Domain	Members of this family are found in 3-mercaptopyruvate sulfurtransferase, and have no known function. They adopt a structure consisting of a four-stranded antiparallel beta-sheet and an alpha-helix, arranged in a beta(2)-alpha-beta(2) fashion, and bearing a remarkable structural similarity to the FK506-binding protein class of peptidylprolyl cis/trans-isomerase [1].	20.10	20.10	21.00	90.50	19.40	19.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.25	0.72	-4.20	3	12	2012-10-02 13:30:10	2006-08-11 15:37:18	5	1	12	1	3	13	0	68.20	59	18.13	CHANGED	MLhpMhSPSLGDNPKAsL.DssTLlVDGslVspPDAELpSAlsHLHlGE+ApVaFKSpRVVVIEV.PtlP	MhhpM.oPsLGDNPKAsL.DshTLhVDGssscpPDAElpSAhsHLHhGEtApVaFKStRVVsIEV.Phls....	0	1	2	3
+8955	PF09123	DUF1931		Domain of unknown function (DUF1931)	Sammut SJ	anon	pdb_1r4v	Domain	Members of this family, which are found in a set of hypothetical bacterial proteins, contain a core of six alpha-helices, where one central helix is surrounded by the other five. The exact function of this family has not, as yet, been determined [1].	28.20	28.20	28.20	80.60	25.60	28.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.46	0.71	-4.22	14	60	2009-01-15 18:05:59	2006-08-11 15:53:48	6	1	55	10	36	63	1	137.20	42	90.89	CHANGED	h-+lFRpsAuLDlc..Ks-hcRhsDhVpcKlYDLLlsuptsAptNsRDlIc.hDLPITKGLpEoIcpF+pl..-c-lELcsIL-hLA...........shPPLDhslupEscscLP-IsGGLslslARshKhlcP-lKs..PpsEchEcspplhD	.F-+lFRpAAGLDVD..KsDlKRhsDhVccKlYDLlllAptsAKuNsRDlIc.hDLPITKGLpESl+pF+pl..DcclELcPlL-tLs...........shPPLDlslu--scscLP.IsGuLsVAlARshKtlcP-lKN..PpspHaEcApclhc....	0	15	25	33
+8956	PF09124	Endonuc-dimeris		T4 recombination endonuclease VII, dimerisation	Sammut SJ	anon	pdb_1e7l	Domain	Members of this family, which are predominantly found in Bacteriophage T4 recombination endonuclease VII, adopt a helical secondary structure, with three alpha helices oriented parallel to each other. They mediate dimerisation of the protein, as well as binding to the DNA major groove [1].	21.60	21.60	21.60	21.60	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.64	0.72	-4.34	8	37	2012-10-03 03:04:30	2006-08-14 09:14:20	5	2	35	10	1	30	0	53.20	48	34.94	CHANGED	IHPpalsDpsKpFSRLs+sEMhAEMpucGF-Ys-sDsKspLscpF+KQhhKul+	.....IHPpalsDKsKcFSRLsKpEMhAEM.ppGF-YN-uDTKspLltsFKKQl+KulK.......	0	1	1	1
+8957	PF09125	COX2-transmemb		Cytochrome C oxidase subunit II, transmembrane	Sammut SJ	anon	pdb_1ehk	Domain	Members of this family adopt a tertiary structure consisting of two antiparallel transmembrane helices, in a transmembrane helix hairpin fold [1].	25.00	25.00	25.10	25.10	22.40	21.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.04	0.72	-4.41	2	13	2009-09-11 15:01:49	2006-08-14 09:34:59	5	1	13	26	6	15	2	37.60	62	22.94	CHANGED	DEHKAHKAILAYEKGWLAFSLAMLFVFIALIAYTLATH	.....DEHKAHKAILAYEKGWLsFuLAMllVFIALIAYTLATH...	0	1	4	6
+8958	PF09126	NaeI		Restriction endonuclease NaeI 	Sammut SJ	anon	pdb_1ev7	Domain	Members of this family adopt a secondary structure consisting of nine alpha-helices, six 3-10 helices and 13 beta-strands. They bind two GCC-CGG recognition sequences to cleave DNA into blunt-ended products [1].	25.00	25.00	101.80	101.60	18.90	17.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.58	0.70	-5.77	6	31	2012-10-11 20:44:45	2006-08-14 09:51:55	5	1	28	4	10	34	1	279.50	35	60.68	CHANGED	Dt-LLhshts.hoscssGch.....huuhLRcCIDsVl.s.+TGRhsa--L-KTEKTaIGTcVEIELRAhhphscG.chDh.......Ihs.sVDlKhoM.GuNWMlPsEulDs.lCLLVtADEt+ARhhlGLlhsRPsaLTpup..N+DuKpslospG.huslLWLhpDH.PhPtNhhhplsscshspIFAspo......GssRhAcLFRclQtcPIsRsVlcAVApQcDFMRRlRust..GsRslLccEGILlLuGp.hDspLhpALsLPsssuupalSsRlhhtc.tch.............st.suD.llpLs	.......................hhht..hphcssGph.....hutslRcolDpllDsp+TGRasa..cpLpKTEKTalGThlEIpLpcpFt..h..sc.G......phDh.......ItGh-VDsKaohp...ttsWMIP.Euh............sp....hsLlltAD-ppupassGLl+scs-hL......st.ut........NRDuKpslo.....spu.+pt.lhWLacct..Ph.tNhLLpLst.pshppIh.u.spS.......GppRlspLFRplppp.lsRslVtsV.A.pQcDaM+RlR.su..GuRshLp.EGIllLusp...pctplApsLsLPhsstuEalSsRls.tp.tct.t.ts.hts..WhhA..s-......s.........................	0	0	5	9
+8959	PF09127	Leuk-A4-hydro_C		Leukotriene A4 hydrolase, C-terminal	Sammut SJ	anon	pdb_1hs6	Domain	Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase [1].	21.20	21.20	21.20	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.70	0.71	-4.59	37	628	2012-10-11 20:01:01	2006-08-14 10:36:11	6	10	372	47	367	640	57	142.00	25	23.77	CHANGED	oLscsshsLup.cWhst..t.......stphsstDlpsasspQhlhFLspL............hptps...ls.pp..lptLscsY..plssSpNuElth+ahplsl+....uphp..shhsphtcaL..sphGRMKFlRPlY+tLsp.....hs+phAlcsFpct+stYHPlspthVpKDL	...........................................................hhp.s.tLup.tWhpt..t.................ttshsstsh.psasspQhlhFLspL.........................h..tps.....Ls.pp..lppL..sc.sY..plssopN.u.El.phRW..hplslc....sc....ap....ssh..tstcaL.......pp..GRhKastPLYcsLhp....ttscshAhcsFtps+sthHPlstthlpc.L......................................	0	113	181	274
+8960	PF09128	RGS-like		Regulator of G protein signalling-like domain	Sammut SJ	anon	pdb_1htj	Domain	Members of this family adopt a structure consisting of twelve helices that fold into a compact domain that contains the overall structural scaffold observed in other RGS proteins and three additional helical elements that pack closely to it. Helices 1-9 comprise the RGS (Pfam:PF00615) fold, in which helices 4-7 form a classic antiparallel bundle adjacent to the other helices. Like other RGS structures, helices 7 and 8 span the length of the folded domain and form essentially one continuous helix with a kink in the middle. Helices 10-12 form an apparently stable C-terminal extension of the structural domain, and although other RGS proteins lack this structure, these elements are intimately associated with the rest of the structural framework by hydrophobic interactions. Members of the family bind to active G-alpha proteins, promoting GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways [1].	21.10	21.10	21.30	21.10	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.03	0.71	-4.80	9	251	2012-10-03 22:10:09	2006-08-14 11:04:46	6	13	79	9	111	223	0	172.50	40	14.50	CHANGED	psusFQsl-.L....KSRPAHLAVFL+aVloQh.DPusLLsYLhu.DhYpp..ssuKEsR+hhh-hashFL-+sA.sL+lsls-plsh-l..........................ptp+scLhsp-htRthlppspppshs-lpcpLpD.............FRpKRoMGLs.hpuEhspL-t.httDhs....+ERpsA.Eplls+l...t-lL.stpshE..E-+osshpaslhTYM++lGV+	........................................su.FQslEhL....KpRPAHLuVFLpaVhSQh..DPuPLL..........hYLhu.-hYpp......ss..sK-....sR+hhh-haphFL-+sA..sL+V.p.l.P-..plsh-l..........................-h.h.cs-.Lhsp-hhRphl.pphpppshs-lpcpLcD.............F..Rp..KRohGLssh.uEhstL-..hstDph......+ERpsA...Ep.l.l.sp..l..........t-hl...p....p..s.E.......E.-+Ssshthsl.hYMpHhGl+..................................................................	0	25	34	64
+8961	PF09129	Chol_subst-bind		Cholesterol oxidase, substrate-binding	Sammut SJ	anon	pdb_1i19	Domain	The substrate-binding domain found in Cholesterol oxidase is composed of an eight-stranded mixed beta-pleated sheet and six alpha-helices. This domain is positioned over the isoalloxazine ring system of the FAD cofactor bound by FAD_binding_4 (PF:PF01565) and forms the roof of the active site cavity, allowing for catalysis of oxidation and isomerisation of cholesterol to cholest-4-en-3-one [1].	25.00	25.00	27.90	27.90	19.30	16.30	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.89	0.70	-5.30	3	72	2012-10-02 00:48:38	2006-08-14 11:36:47	6	3	62	4	14	78	1	295.20	57	53.89	CHANGED	RhRCQSYVDIPASELFAPAGScGRTFESFVp+SGRAEAIWFPFTDKPWLKVWTVoPT+PsG...................ARsVsGPYNYPFSDNIPcslSDLluAIN.sGcPpLAPLFGKsQY-IThLGLAsThG..sDLWGWSKDVLaYIKPTTLRVTANGYAVLTRRcNVQRVINEFsttY+pRIAsYRAsG+YPlNGPVEIRVoGLDQPADVtVPGAsPPSLSAIRPRPDHPDWDsAIWLDILolPGTPsANcFYREhEQWMhSHYSGDYATlRPEWSKGWGYuPsAAWoDsslVssplssoaRpGLsss-NWDoAlRpLNchDPHRVFSSPLLDRLMP	........................RhRCpSassIPAsELFA.AsGo..s.G....RTh-SFlp+SGRsEAIWFPFT-pPWLKVWTssPs+P.s...................uRsVstPYNYPFSDsIPctloDLlupIs.sG.pstLsPLhGphQYslshsGLshThs.........hDLWGWS+slLhYl+PTTLRVTANGYAVLTRRtslQRVIsEFsthYpphlstY+AtGcYPhNGPlEIRVoGLDpPu-sh.sGAhsPoLSAlRPRPD..+PE..WDsAIWhDlLolPGTPtAstFYREhEpWhhsp..aoGsYAolRsEWSKGWGYss.sAAWsDsshlsphlsp.hRpG.lsusssWDsAhtpLschDP+RlFSSPLLDRLhs................	0	4	11	13
+8962	PF09130	DUF1932		Domain of unknown function (DUF1932)	Sammut SJ	anon	pdb_1i36	Domain	This domain is found in a set of hypothetical prokaryotic proteins. Its exact function has not, as yet, been described.	25.00	25.00	25.00	25.10	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.30	0.72	-4.24	45	239	2009-01-15 18:05:59	2006-08-14 11:43:05	6	8	206	4	130	266	129	73.40	27	24.62	CHANGED	AcphGVp-pllsoLspohPuhsh..ppsshhlscshtHuhRRstEMcElucTlpssGl.........sst...hspusAshhpphuc	..............AcphGVt-tllssLspoh.Puhs...phsshhlspss.HuhRRspEMc.Elucslp-sGl.........................ssh....hscusAphhptls.........	0	32	77	108
+8963	PF09131	Endotoxin_mid		Bacillus thuringiensis delta-Endotoxin, middle domain	Sammut SJ	anon	pdb_1i5p	Domain	Members of this family adopt a structure consisting of three four-stranded beta-sheets, each with a Greek key fold, with internal pseudo threefold symmetry. Thus they act as a receptor binding beta-prism, binding to insect-specific receptors of gut epithelial cells [1].	21.20	21.20	21.70	21.50	20.00	21.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.39	0.71	-4.86	3	68	2009-01-15 18:05:59	2006-08-14 13:04:28	5	5	9	1	0	63	0	192.60	70	32.83	CHANGED	LLVSSGANLYASGSGPQQTQSFTAQNWPFLYSLFQVNSNYVLSGlSGARLoITFPNIGGLPGSTTTQoLpuARVNYSGGVSSGpIGusNLNQNFNCSTlhPPLSTPFVRSWLDSGTDREGVATSTNWQTESFETTLuLRCGAFSARGNSNYFPDYFIRNISGVsLVIRNEDLsRPLYYNEIRNIESPSGTPGGARAYLVSVHNRKN	....................LLVSSGANLYASGSGPQQTQSFTuQsWPFLYSLFQVNSNYVLsGhSGARLohTFPNIsGLPGSTTTpuLhuARVNYSGG.........l.SSGpIG....u....osh.....NQ............N.................FN...C.STlhPPL.TPFVRSWLD...SGoDREGVATsTNWQTESFETTLuLRsGAFoAR.GNS.NYFPDYFIRNISGVsLVlR.NEDLpRPLHYNEIRNItSPSGTPGGARAYhVSVHNRKN.......	0	0	0	0
+8964	PF09132	BmKX		BmKX	Sammut SJ	anon	pdb_1rji	Domain	Members of this family assume a structure adopted by most short-chain scorpion toxins, consisting of a cysteine-stabilised alpha/beta scaffold consisting of a short 3-10-helix and a two-stranded antiparallel beta-sheet. They are predominantly found in short-chain scorpion toxins, and their biological method of action has not, as yet, been defined [1].	20.70	20.70	24.70	29.20	20.00	19.70	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-7.50	0.72	-4.08	2	14	2009-01-15 18:05:59	2006-08-14 14:09:14	5	4	4	2	5	15	0	29.90	55	20.45	CHANGED	PhsspCKscpDssMCshGhSsKsGhCpuCT	PVsGECKscsDAsMCTsGsssKs.GTCTuCT...	1	5	5	5
+8965	PF09133	SANTA		SANTA (SANT Associated)	Zhang D, Mistry J	anon	Zhang	Domain	The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota.  It is sometimes found in association with the SANT domain (Pfam:PF00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling [1].  Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes [1].  Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions [1].	20.90	20.90	21.10	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.21	0.72	-4.03	7	120	2009-01-15 18:05:59	2006-08-14 14:20:17	5	5	73	0	79	112	0	91.90	32	12.64	CHANGED	lpLpDWhlKphsps.....ltlcGh.cspps...hhasSshIscRhpsshLcs.sGhhhsLhGhl..............sppph.csGhs.clhccFhhGFP..Wcchh.st.	.........................................lpLp-Whlc.hhss.s................tlsVpGh..tsp...ss...........hha+...S.....ssIlcRhppspLcThsGplYhLpGhl..............sp.phccs..G..aPstl.......hc+Fhh......G....FPcpWcchlpp..h.........	0	21	35	58
+8966	PF09134	Invasin_D3		Invasin, domain 3	Sammut SJ	anon	pdb_1cwv	Domain	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, arranged in a Greek-key topology. It forms part of the extracellular region of the protein, which can be expressed as a soluble protein (Inv497) that binds integrins and promotes subsequent uptake by cells when attached to bacteria [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.30	0.72	-4.14	2	269	2012-10-03 16:25:20	2006-08-14 14:36:03	5	18	254	1	6	214	8	102.50	72	8.12	CHANGED	PDsspSSFsVSssDIlADGoMpShLoFVPhsKNscFlSGhpsLpFhQsGVPVoISPlTEpsDsYTAoVVGNosGDVsITPQVss..LshLQK+IoLaPl	.....M.DVANS..TLSANEPSGDVVADGQQAYTLTLT..AVDSEGNPVTGEAS.....R...L.RF...V..PQ....D.T.......N....G....VTV...G..A...I...S...E.IK..P...G..V...Y.SA...T.VSSTRAGNVVVRAFSEQYQLGTLQQTL.....KFVA............	0	0	2	2
+8967	PF09135	Alb1		Alb1	Mistry J, Wood V	anon	manual	Family	Alb1 is a nuclear shuttling factor involved in ribosome biogenesis [1].	20.40	20.40	23.00	23.00	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.79	0.72	-3.45	48	156	2009-01-15 18:05:59	2006-08-14 14:58:35	6	1	117	0	115	151	0	110.10	28	63.64	CHANGED	h+SRAARRtss.shs.h-+.......p.lpsls....sccsshp+stlhsspp.......suslsccp..t...+spc.....ls.+tpp..........hpppsh-+AthlhcpLspKhsKSlsR.uKhlpp..R+ssW-phNpphppp	.............................hpSRAARptspsshs.h-+.......p.h.p.sls....sccsshp+stlhsst+.............suulsccp.......+spp.......ls..ppppp...............tpccuhc+AphshcpLspKlsKSlsR.sKhlpp..R+tsW-phNpph...t............	0	16	54	96
+8968	PF09136	Glucodextran_B		Glucodextranase, domain B	Sammut SJ	anon	pdb_1ug9	Domain	Members of this family adopt a structure consisting of seven/eight-strand antiparallel beta-sheets, in a Greek-key topology, similar to the immunoglobulin beta-sandwich fold. They act as cell wall anchors, where they interact with the S-layer present in the cell wall of Gram-positive bacteria by hydrophobic interactions. In glucodextranase, Domain B is buried in the S-layer, and a flexible linker located between domain B and the catalytic unit confers motion to the catalytic unit, which is capable of efficient hydrolysis of the substrates located close to the cell surface [1].	29.80	29.80	30.50	31.50	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.24	0.72	-3.82	2	5	2009-01-15 18:05:59	2006-08-14 16:35:04	5	3	4	2	0	7	0	74.60	39	8.58	CHANGED	PtLolsuPttLoTADSAsssVpGTTsAAKVYVSVNGshhEAPlT...DG..TFSlDlALsusKNpVTVAAVuuDGGTAVEsRTVLaYGS	...PuLTVpu.sshSsssStTspVSGTTNAuKVhssVNGptTEhPVo...pG..oausDLsLstscN+VTlsAsGucGuoAopcRTlhtYG.......	0	0	0	0
+8969	PF09137	Glucodextran_N		Glucodextranase, domain N	Sammut SJ	anon	pdb_1ug9	Domain	Members of this family, which are uniquely found in bacterial and archaeal glucoamylases and glucodextranases, adopt a structure consisting of 17 antiparallel beta-strands. These beta-strands are divided into two beta-sheets, and one of the beta-sheets is wrapped by an extended polypeptide, which appears to stabilise the domain. Members of this family are mainly concerned with catalytic activity, hydrolysing alpha-1,6-glucosidic linkages of dextran to release beta-D-glucose from the non-reducing end via an inverting reaction mechanism [1].	19.50	19.50	19.70	20.50	18.00	19.20	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.66	0.70	-5.16	14	171	2009-01-15 18:05:59	2006-08-14 16:38:33	6	8	150	6	82	181	17	265.40	31	32.85	CHANGED	AsGuPGtsssWu.usKpGVGTu..............ssssSKVWFTlucGlloEVYYPpIDpAph+-LpFlVsc.GpsFhs-EpcDTtScl-hhs......stohuY+lsssDppGRYpIpKcIFTDPcRsullh+VpFpALcG...tDaplYlLhcPHlsNsGusssuals.cuput.sLhAptssshhALsuShsats......sSsGaVGsSDGhoDLt...tssphshpassAsp...GNlu.sucIsL.stspT..pFslsLGFGpotpEAspsAtuoLpsuasphhppY.s.....sWccYhsSL	...................................................A.GuPGtss..pWs..usKsGlGTu..................hsssS+VWFTl.ucG.lloElaYPplDpspl+-.lpFlV..ss...GpsFh.........spE+css....p....pplchhs.............sts.uac.ls...sp.s....tp...G+...aplpKclhoDPp+ssllh+lpFpu.hps.......shphYhlhsP+lsNsG.......t.......s..............spuhs.....p.....h...........tut.t...s..........Lh.A.pp............s..................sthhuLtu......sh.....s.....att.....................sSsGal.G.s.......SDGhpDLt......pstph...sh.p..aspAss............GNVuhsuplsh.......tsps......phslsLGFGpotp..p..A..hssAtuoLsp.u..apshhppYts.....sWcsahtsL.............................................	0	29	53	71
+8970	PF09138	Urm1		Urm1 (Ubiquitin related modifier)	Mistry J, Wood V	anon	Pfam-B_16507 (release 20.0)	Family	Urm1 is a ubiquitin related protein that modifies proteins in the yeast ubiquitin-like pathway urmylation [1]. Structural comparisons and phylogenetic analysis of the ubiquitin superfamily has indicated that Urm1 has the most conserved structural and sequence features of the common ancestor of the entire superfamily [2].	21.00	21.00	21.00	21.30	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.19	0.72	-3.87	29	304	2012-10-03 10:59:06	2006-08-14 17:07:09	6	2	274	6	211	350	18	94.70	42	89.71	CHANGED	clplEFhGGLElLhs.sp+paplsls.......sppthshpsLltalcpNlIp-.Rs.-lF..........................l.p.ssolRPGILVLINDsDWELhGph-YhLc-sDslsFlSTLHGG	.........................................lplEFsGGhEhLFs..s.+pHplsls.....................t.tp.hslppLlpalpcNllp-.....Rs..-LF..................................................................lp...ssoVRP.GILVLINDsDWE.L...G..c.-Y.Lpss.DslhFlSTLHGG........................	1	72	114	175
+8971	PF09139	Mmp37		Mitochondrial matrix Mmp37	Mistry J, Wood V	anon	Pfam-B_15301 (release 20.0)	Family	MMp37 is a mitochondrial matrix protein that functions in the translocation of proteins across the mitochondrial inner membrane [1]. It has been shown that MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane [2].	21.10	21.10	21.80	21.80	19.20	19.00	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.34	0.70	-5.41	24	355	2012-10-02 22:47:23	2006-08-14 17:14:10	6	8	272	0	247	347	4	275.80	34	80.49	CHANGED	tL+pllspF.ss.lcaAFAYGSGVapQsG................t........tt.pttMlDhIFuVscspcaHohNLcQN.cHYSs..L+hhGschloplQsphGAGVYFNsalslN.....GphIKYGVVShcsLhcDLtpWcoLYlAGRLpKPV..clLp.c...csplchssphNL+SAlpsALLLL.......PppFoEhpLYppIuGLSYhGDhRM.lsG.EsPpKVpNIVpsphsp..F+cLYtPllps....................h.phsh.s..t..............phtpDhss.sphshlttLPp.shppplhhphpp.h..........................ptppst.h.hplutDs..ph.tpslppslpphlphsShsQolKGlhTAGlt+SlpYuhtKhpK	.............................h.hptlh.pF....lph..sFuYGSGVh.Qts...............................................ttpttMlDhlhsV....sps...pWHshNlppp.pHYSh......l.t..hh..G....st.hlsp.....lQp...h.G..AG.VYaNs.hl.hs..........uphl..KYGVlshcsLhpDLhpWpsLYlAGRLpKPV...cl..l.p...s...............ssplp....hs...phNLhuAlps....AlLhL....................................PtpF..o....E.pLatpIsuLSYh.GDhR..M...lhu.Es.pKVpNIVp..sp..htp..FcpLYt.sllpp.........................h.ph.h.........................thhh.t..D.hs.s.tphp.l.tLPt.phpppl.h.ht.........................................................................t.h.......p..l..u..tp....ph..tp.lppslpphlhhsShhQohKGlhoAGhh+ohtY..tKh.K......................................................................	0	80	139	203
+8972	PF09140	MipZ		ATPase MipZ	Mistry J, Thanbichler M	anon	Pfam-B_23525 (release 20.0)	Family	MipZ is an ATPase that forms a complex with the chromosome partitioning protein ParB near the chromosomal origin of replication [1].  It is responsible for the temporal and spatial regulation of FtsZ ring formation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.76	0.70	-5.31	12	431	2012-10-05 12:31:09	2006-08-14 17:22:01	6	7	400	5	138	13620	5467	180.40	27	57.60	CHANGED	HlIVlGNEKGGoGKSTsulHlAlALhttGh+VusIDLDhRQ+ohsRYhcNRsthtc+p.GlsLPhPpah........pl.cs-ssp..phpthhschptstDFIllDTPGscohLuRhAHohADTLVTPlNDSFVDFDllupVDPcThclptPShYuEhVW-uRptRAps....sttshDWlVlRNRLuthpuRN+p+lspuLp-LS+RlGFRlhsGhuERVIYRELFPpGLTLL.Dlpchsh..chshSHlsARQELRsLltuLsLPh	.............................................................................llsV..u..s.tKGGsGKST.lo..h....p...........L.A..l.....A....L...s.......+.....h.....G.......h....+.....VG.l........l.D...............sD...............l..............h.................t.................................S..................l..................s..................p................h....................h..............t...................s...................+..................t...................h....................h.....................................t...................p....................p....................................h......................................l............................................h....................................t............h....................h..........................................l........................................................................................................................h.........................................................t.............................................h.......................................................................h............p......t.....h...h......t.......p.........h..........t.............p.......h....D......a..lllD..h.P...s......................................................................................................................................................................................................................................................................................................................................................th............................................................................................................................................................................	0	46	90	114
+8973	PF09141	Talin_middle		Talin, middle domain	Sammut SJ	anon	pdb_1sj7	Domain	Members of this family adopt a structure consisting of five alpha helices that fold into a bundle. They contain a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin [1].	25.00	25.00	35.30	25.20	24.90	23.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.71	0.71	-4.56	6	194	2009-09-11 14:56:09	2006-08-15 09:39:34	5	31	87	6	108	161	0	157.90	59	6.87	CHANGED	sQpALhGoIsuuhcAVppA-c-Lcshss..lPsLGsDhuShpW+cNplDsSKpsVsS+lAAhoAuTApVVphTAu-PsDsDasAVGsAVosIouNLsElSKsV+LlAALM-c-s.sGccLL-AARsLsuAFSDLLKuApPpS...cEPRQsLLsAAGpVGpuSucLL	.................................AQQALhGTINoSMpAVQtAQssLs....-h-s...LP.PLGpDhAS+...sWhpNKhDESKHEIHSQVDAITAGTASVV...........NLTA..G.DP......s-TDYTAVGCAlTTISSNLTEMSKGVKLLAAL..M-D-s...GsGcsLLpAA+sLAGAVSDLL+u.spPsS.........................uEPRQslLsAAGslGQASG-LL......................	0	33	42	70
+8974	PF09142	TruB_C		tRNA Pseudouridine synthase II, C terminal	Sammut SJ	anon	pdb_1sgv	Domain	The C terminal domain of tRNA Pseudouridine synthase II adopts a PUA (Pfam:PF01472) fold, with a four-stranded mixed beta-sheet flanked by one alpha-helix on each side. It allows for binding of the enzyme to RNA, as well as stabilisation of the RNA molecule [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.31	0.72	-4.32	34	629	2012-10-02 17:37:24	2006-08-15 10:01:30	6	7	616	2	142	459	81	55.70	33	18.30	CHANGED	FsthclossEApslsaG+tLsss....uhsGshAAhsPDGcllALl...c-putcs+slsVht	......................................hshhplTscEAstlphGRhlphs....................shst.h.hA.Ahs.s.cG+......llAll........cc..cGsp....h+sltVh................	0	43	99	129
+8975	PF09143	AvrPphF-ORF-2		AvrPphF-ORF-2	Sammut SJ	anon	pdb_1s21	Domain	Members of this family of plant pathogenic proteins adopt an elongated structure somewhat reminiscent of a mushroom that can be divided into 'stalk' and 'head' subdomains. The stalk subdomain is composed of the N-terminal helix (alpha1) and beta strands beta3-beta4. An antiparallel beta sheet (beta5, beta7-beta8) forms the base of the head subdomain that interacts with the stalk. A pair of twisted antiparallel beta sheets (beta1 and beta6; beta2 and beta9/9') supported by alpha2 form the dome of the head. The head subdomain possesses weak structural similarity with the catalytic portion of a number of ADP-ribosyltransferase toxins [1].	25.00	25.00	28.70	28.20	24.50	23.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.05	0.71	-4.55	4	50	2009-01-15 18:05:59	2006-08-15 10:31:42	5	1	47	1	4	43	1	156.10	48	71.89	CHANGED	SpalGt.TLTSIHQLSsspREpFLssHDPMRshsLss-TslYRTTppRYl....+psKLAGNPpShAhlthHEELp.ss.hAS+..hGuhPcpAc.........AYhP+ph+AsDLssPSLNVMsGstAcsulRuYA+..sDHVsVcMRLGDFL-pGGKVYuDTSuhusGGDpspALIVTLPKGpKVPVcIl	................hstpshul................................F+I++DhVsVRIpsspFsD..hKNcKIpGHpNTVASVhDaYs.QcNu.Lu.s..hGosc+.oAD.........hh+.c++sAhNhhlhphNs.hap......s......us-Nht+SYuK.T-DsshVuholGsLLDKG.uKVYsDTSsulc...LuEPhIhTLPEus+VsV-I.............................	0	0	1	3
+8976	PF09144	YpM		Yersinia pseudotuberculosis mitogen	Sammut SJ	anon	pdb_1pm4	Domain	Members of this family of Yersinia pseudotuberculosis mitogens adopt a sandwich structure consisting of nine strands in two beta sheets, in a jelly-roll topology. As with other superantigens, they are able to excessively activate T cells by binding to the T cell receptor [1].	25.00	25.00	205.40	205.20	19.30	18.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-4.14	2	4	2009-01-15 18:05:59	2006-08-15 10:43:22	5	1	2	4	0	5	0	116.80	90	77.45	CHANGED	IPNIATYTGTIQGKGEVCIIGNKEGKTRGGELYAVLaSTNVNADMTLILLRNVGGNGWGEIKRNDIDKPLKYEDYYTSGLSWIWKIKNNSSETSNYSLDATVHDDKEDSDVLTKCPV	IPNIATYTGTIQGKGEVCIIGNKEGKTRGGELYAVL+STNVNADMTLILLRNVGGNGWGEIKRNDIDKPLKYEDYYTSG.LSWIWKIKNNSSETSNYSLDATVHDDKEDSDVLTKCPV	0	0	0	0
+8977	PF09145	Ubiq-assoc		Ubiquitin-associated	Sammut SJ	anon	pdb_1pgy	Domain	Ubiquitin associated domains contain approximately 40 residues and bind ubiquitin noncovalently. They adopt a secondary structure consisting of three alpha-helices, and have been identified in various modular proteins involved in protein trafficking, clathrin assembly/disassembly, DNA repair, proteasomal degradation, and cell cycle regulation [1].	20.20	20.20	20.30	56.80	18.60	16.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.22	0.72	-4.10	4	19	2009-01-15 18:05:59	2006-08-15 11:59:10	5	4	19	1	13	20	0	45.50	60	6.90	CHANGED	llDEV+DMElA+LMSLGLsI-cAscYY-+GlpYE...-.L+pR+pc	lVDEVKDMEIARLMSLGLSI-cAs-aYEpslhYEphl-hlKp+pt.....	0	1	6	12
+8979	PF09147	DUF1933		Domain of unknown function (DUF1933)	Sammut SJ	anon	pdb_1q15	Domain	Members of this family are predominantly found in carbapenam synthetase, and are composed of two antiparallel six-stranded beta-sheets that form a sandwich, flanked on each side by two alpha-helices. Their exact function has not, as yet, been determined [1].	20.50	20.50	20.50	20.60	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.24	0.71	-4.89	3	6	2012-10-03 21:14:07	2006-08-15 13:47:08	5	2	6	8	4	26	83	199.20	38	44.24	CHANGED	N-FClV+tGhDKDINpLt+-FsGphEtLSNGsLFhcpsT+VQKa+hERGTAYLIGSLYN+ohLRuLAG+aEGcusVlNDAEILhLlpT+LGuuALuLAEGDFCFFIED+NGsLTVITESRGhNPVaLVQucctWITNSLKLVoAlEG-tAhDFccEupVscoul+sDsaoPl+NlQRLKPGTlNVLTFDspcYpalESRpL	...............................spFChl+tuhsKNlsplhpsF.shph-pLSsGpLahpspophpKhcs-+tTAYLI..GoIYN+shLculAG+aEGcu..VlsDsElLhhlhs+LGsuALoLAEGDFCF.FI.E-Kp.G.pLpllT-SpGhssVaLVp...sc.h.hWI.TN.oLKlVu..t.lEG-tAhDFpsEu..pVhpssL..+..sDsaoPl+NspRLKPGolNhLoaDppcY.alEsc.l.......................................................	0	0	2	3
+8980	PF09148	DUF1934		Domain of unknown function (DUF1934)	Sammut SJ	anon	pdb_1r0u	Domain	Members of this family are found in a set of hypothetical bacterial proteins. Their precise function has not, as yet, been defined.	21.40	21.40	21.50	22.20	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.32	0.71	-4.43	66	1332	2009-09-10 22:25:01	2006-08-15 13:52:04	5	1	1317	1	164	708	2	126.10	26	91.48	CHANGED	l......pIphpphh..........tpsc.p-slEhhspGpahpKs.sshYlhYcEp..p.ss...sspsslKl..pcscltlhR...tGssph+hh.FppsccshshYpTPhGphpltspTpplplshs-ps...GplplcYpLh....hspphhuphplpl	..................................hpIphpshl.......p..tssc..pEph-.hhhp...Gphhp.+s.stpYlpYpEp..p.tt....phplslKl....pcpplhlhR...tGs.sphph+.Fhc.sp.c.shs.hYs.TP.hG.h.hpltspTppl..p.h.phpct.........tplpl.....cYpLh....tssphhusYplcl......................	0	64	110	138
+8981	PF09149	DUF1935		Domain of unknown function (DUF1935)	Sammut SJ	anon	pdb_1r75	Domain	Members of this family are found in various bacterial and eukaryotic hypothetical proteins, as well as in the cysteine protease calpain. Their exact function has not, as yet, been defined.	20.90	20.90	20.90	25.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.35	0.72	-4.05	71	300	2009-01-15 18:05:59	2006-08-15 14:02:30	5	8	15	2	76	289	0	104.30	31	23.51	CHANGED	ppGp...Ps...hp....sclhpsFcp...........G.........LLFRlVs.p................cppp..WuFYNDTpcaphcVpspFutsSp.l....csLssT..plt.........ppssGp........hhsplsVhPhcTphFl.cGps.sGacs.phpAhs	............................................GtPs.....hp.......sclhpsFcp...........G..........LLaRlls.p......................cppp....WuFYNDTpsaphcVpspFutsSp.l........pslssT..plp...............ppssGp...............hhsplsVhPhcTphFl.cGps.sGapsphpA.................	0	38	56	76
+8982	PF09150	Carot_N		Orange carotenoid protein, N-terminal 	Sammut SJ	anon	pdb_1m98	Domain	Members of this family adopt an alpha-helical structure consisting of two four-helix bundles. They are predominantly found in prokaryotic orange carotenoid protein, and carotenoid binding proteins [1].	25.00	25.00	64.60	64.60	23.40	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.90	0.71	-4.54	8	95	2009-01-15 18:05:59	2006-08-15 14:34:12	5	2	47	8	43	100	4	155.00	45	65.57	CHANGED	ThDsA...Fs.ohtussV.sllspFNpLss-DpLALlWFsYpEMG+oITsAAPGAA..shpLAEuhLsplptho.cE.QhplMpDLss+sDTPloRsYGsaSsNsKLsFWYpLuEhMcQGsVsPlPsGYQLSssANplLEsIKsLDhGQQITlLRshVlsMGaDs	..............s............s..usslssshspFppLos-DQLALlWFuYhEMGcoITsAAPGAA..phphA-shLspI+pMo.pE.QhplMpDLAs+s-...Tsl.oRsYushSsNsKLuFWYpLuchMcpGhVsPlPsuYpLSssAsslLpsIcsL-.uQQITlLRssVs-MGhDs...........	0	5	27	42
+8983	PF09151	DUF1936		Domain of unknown function (DUF1936)	Sammut SJ	anon	pdb_1pvm	Domain	This domain is found in a set of hypothetical Archaeal proteins. Its exact function has not, as yet, been defined. It possesses a zinc ribbon fold.	25.00	25.00	98.90	98.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.81	0.72	-4.45	2	2	2012-10-03 10:42:43	2006-08-15 15:04:02	5	1	2	4	2	5	1	36.00	89	20.45	CHANGED	pHLCPKCGVGVL.PVYspKGEIKVFRCSNPACDYEE	pHLCPKCGVGVL.PVYspKGEIKVFRCSNPACDYEE	0	1	1	1
+8984	PF09152	DUF1937		Domain of unknown function (DUF1937)	Sammut SJ	anon	pdb_1t1j	Domain	This domain is found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been described.	23.00	23.00	23.00	23.40	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.41	0.71	-3.52	7	46	2012-10-02 19:28:18	2006-08-15 16:31:34	5	1	35	2	10	39	1	111.80	41	80.93	CHANGED	RhlaLAsPYS........+.stshlptphhssschAApllcsGhssaS.VohS....HPI.hshs.h.cst.stlWushst.ahchhptllVl-lsGWccSsGI++Elchatstsp.V.laup	..R.laLAsPYS........+sss-hsEtphtssschsAp....llc.sGhsshS.VshS....Hsh.hshh..h.csh.stLWtshst.hhcth.ptllVh-lsGWccSsGIR+ElchhpAtsh.V.lau........	0	7	7	10
+8985	PF09153	DUF1938		Domain of unknown function (DUF1938)	Sammut SJ	anon	pdb_1mgt	Domain	Members of this family, which are predominantly found in the archaeal protein O6-alkylguanine-DNA alkyltransferase, adopt a secondary structure consisting of a three stranded antiparallel beta-sheet and three alpha helices. Their exact function has not, as yet, been defined, though it has been postulated that they confer thermostability to the archaeal protein [1].	22.10	22.10	24.80	94.00	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.65	0.72	-4.17	4	13	2009-01-15 18:05:59	2006-08-16 09:16:18	5	1	13	1	11	16	0	86.00	45	49.32	CHANGED	MLoscpF+ltsRtlhIGVlaE-+IQGIsaSlDthEhl+cplscLhsaLpKR.GVplsLcEppScYP-lVFcVLhGKIuNEcuhE..ELS	MLSlE+FcIssR-lhIuVla-cK.IQGIoFSLDGtEFLccRIssLspaLc+R.GVsVsLcpccScYP-LVacVLlGclcNE-uLc..ELS.	0	1	1	6
+8986	PF09154	DUF1939		Domain of unknown function (DUF1939)	Sammut SJ	anon	pdb_1mxg	Domain	Members of this family, which are predominantly found in Archaeal amylase, adopt a secondary structure consisting of an eight-stranded antiparallel beta-sheet containing a Greek key motif. Their exact function has not, as yet, been determined [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.73	0.72	-4.07	9	520	2012-10-02 20:10:03	2006-08-16 09:30:45	5	6	490	22	62	384	5	58.10	47	11.92	CHANGED	LlVhI.Npussh+p+hVpT.sWsspslhDYoGNuu...sssossDGWVplpsPsp.......GYulaS	............hu..lhl.sNsp.t.sS.K.pMaVGp..c.a.s.spsFhD..lLGNpp.........spVTI---GaGpFsVuup.........SVSVWs.	0	18	31	47
+8987	PF09155	DUF1940		Domain of unknown function (DUF1940)	Sammut SJ	anon	pdb_1nig	Domain	Members of this family adopt a secondary structure consisting of six alpha helices, with four long helices (alpha1, alpha2, alpha5, alpha6) form a left-handed, antiparallel alpha helical bundle. The function of this family of Archaeal hypothetical proteins has not, as yet, been defined [1].	25.00	25.00	252.60	252.50	23.20	18.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.83	0.71	-4.35	3	3	2009-01-15 18:05:59	2006-08-16 09:46:44	5	1	3	1	3	4	4	143.00	47	93.87	CHANGED	YCPVIDDpLPlDHVYFKFRSEIEuAEAFLGLAVSEGlKVsETRElLDILDTVYNSLYDcESKLNDFQEKRLNFTEE-WYDIKEKsNNGNKWSLYMFLARSHlDsAVYWlo+M+EDERFK-hVcDEsIstLLKlGhVILREGLG	YCPVIDDpLPlDHVYFKFRSEIEuAEAFLGLAVSEGlKVsETRElLDILDTVYNSLYDcESKLNDFQEKRLNFTEE-WYDIKEKsNNGNKWSLYMFLARSHlDsAVYWlo+M+EDERFK-hVcDEsIstLLKlGhVILREGLG	0	1	2	2
+8988	PF09156	Anthrax-tox_M		Anthrax toxin lethal factor, middle domain	Sammut SJ	anon	pdb_1j7n	Domain	Members of this family, which are predominantly found in anthrax toxin lethal factor, adopt a structure consisting of a core of antiparallel beta sheets and alpha helices. They form a long deep groove within the protein that anchors the 16-residue N-terminal tail of MAPKK-2 before cleavage. It has been noted that this domain resembles the ADP-ribosylating toxin from Bacillus cereus, but the active site has been modified to augment substrate recognition [1].	83.00	83.00	108.40	108.30	82.90	82.90	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.06	0.70	-5.30	2	16	2009-01-15 18:05:59	2006-08-17 09:03:18	5	3	14	17	1	17	0	259.30	97	36.03	CHANGED	MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV	MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV...	0	0	1	1
+8989	PF09157	TruB-C_2		Pseudouridine synthase II TruB, C-terminal	Sammut SJ	anon	pdb_1k8w	Domain	Members of this family adopt a secondary structure consisting of a four-stranded beta sheet and one alpha helix. They are predominantly RNA-binding domains, mostly found in Pseudouridine synthase II TruB [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.78	0.72	-4.11	98	1516	2012-10-02 17:37:24	2006-08-17 09:13:28	6	5	1503	3	305	983	305	58.00	38	18.73	CHANGED	PplpLsspputtlhpGQsV...............sssst..pG.hVRla......spstp..FlGlGclstcG...hltP+RLl	.........PhVsLs.ss.ushhppGpsV........h................s.ss.sPh..cG..hVRVh........ucss+....FlGlGE.l...sc.-.G......+luP+RLl.................	0	68	161	235
+8990	PF09158	MotCF		Bacteriophage T4 MotA, C-terminal	Sammut SJ	anon	pdb_1kaf	Domain	Members of this family adopt a compact alpha/beta structure comprising three alpha-helices and six beta-strands in the order: alpha1-beta1-beta2-beta3-beta4-alpha2-beta5-beta6-alpha3. The beta-strands form a single anti-parallel beta-sheet and the three alpha-helices pack side-by-side onto one surface of the beta-sheet. In this architecture, the domain's hydrophobic core is at the sheet-helix interface, and the second surface of the beta-sheet is completely exposed. The domain is a DNA-binding motif, with a consensus sequence containing nine base pairs (5'-TTTGCTTTA-3'), that appears to bind to various mot boxes, allowing access to the minor groove towards the 5'-end of this sequence and the major groove towards the 3'-end [1].	25.00	25.00	57.50	55.90	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.37	0.72	-4.34	3	25	2009-01-15 18:05:59	2006-08-17 09:29:02	5	2	24	6	0	22	0	102.40	43	49.29	CHANGED	ITuEMcELt-hlhcLl--N.lsLKcVEIYRSNYplIFuKRT.pGIRpFEIpNNGshRIFGYKMuEc+lctFTslGs-lKIthGGpNTYIDIcpsucNItsVlTlA	....ITs-MEp.tDhhhcLL..--p.hs.lKclpp.RSNallhhpKRT.cGIRpFElpNsGphRIFGYKMtE+clppFTslGhssKlttsG.NsYlDIcpos-NIttlIssA...	1	0	0	0
+8991	PF09159	Ydc2-catalyt		Mitochondrial resolvase Ydc2 / RNA splicing MRS1	Sammut SJ	anon	pdb_1kcf	Domain	Members of this family adopt a secondary structure consisting of two beta sheets and one alpha helix, arranged as a beta-alpha-beta motif.  Each beta sheet has five strands, arranged in a 32145 order, with the second strand being antiparallel to the rest. Mitochondrial resolvase Ydc2 is capable of resolving Holliday junctions and cleaves DNA after 5'-CT-3' and 5'-TT-3' sequences [1].  This family also contains the mitochondrial RNA-splicing protein MRS1 which is involved in the excision of group I introns [2-3].	20.00	20.00	20.00	20.70	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.92	0.70	-4.91	53	128	2012-10-03 01:22:09	2006-08-17 10:06:20	5	6	108	2	83	123	59	264.70	23	72.90	CHANGED	I....LSIDhGl+NhAascLps..........................shtssppshP............................pLpsWp....+lsLs.............................................................................pttstppccpp.shsPshhuphAasLlspLl.tshp.....P...shllIERQRhRSsGuuul.EhsL+VsllEsMLaAsLpshppppptt.st..............hVhussPp+lspaWhpttsh.........ps......................tpppphssppsKph+IcLltphLsssh........................hthshsts.ph....h...pthlt+apsptpsppthtthtt...............................................tt.chpKlDDLADsLLpu.lsWhcWppsppcl	.............................ILSIDhGl+NhAasplph................................tttpshs.............................................................................pltsWp....+lsLp.......................................................................................................t.t...ppppp.shs.Pt.huphsapLlppLh..shp..........P.shllIE..R..QRhRosu.u......ssl.-.sl+VshlEshLaAsLpsh.t.ttp...t................hVhussPp+hspaWhp.t.........................................................ppphhssppsKph+lcLltphLpssh........................hth.h..tt.ph............thhtt.attthptththtth.t.................................tt..phtKhDDLsDslLpu.lsWhcW.tthpp..................................................................	0	18	40	69
+8992	PF09160	FimH_man-bind		FimH, mannose binding	Sammut SJ	anon	pdb_1klf	Domain	Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose [1].	25.00	25.00	27.20	27.10	24.00	19.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.74	0.71	-4.36	6	806	2009-09-14 15:18:23	2006-08-17 10:27:01	5	4	326	37	14	375	0	143.80	68	49.23	CHANGED	C+sssTGQ.sh...suGsusVhVNLsPsVpsspNl.VlDLSQ...plsCpND.ushp.hDYlplppGSuFusuLss.......FoGolpahupoYPhPhssps.sphhhspssa+PhPlKhYLoPsuuAsGVlI+uG-LIAplhhpKhuohu.cus.+N.......FsWp	...............C+s.sGsu.sI....GGG....oA...NVY.VNLuPs.VNVGQN.L..VVDLST...QIFCHNDYPE.......TITDYVTL.QR.GSAY.GGVLSs.......FS.GTVKYsG.oSYPFPT.ToET.sRVlYsSRTDKPWPlsLYLTP....VS.o..AGG.VsIKAGSLIAVLIL+QTNNY.....NSD-FQ.......FlWN...........................	0	2	4	9
+8994	PF09162	Tap-RNA_bind		Tap, RNA-binding	Sammut SJ	anon	pdb_1koh	Domain	Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element [1].	20.80	20.80	21.60	21.50	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.86	0.72	-4.41	12	238	2009-01-15 18:05:59	2006-08-17 10:39:35	5	15	77	12	138	237	0	85.00	43	15.68	CHANGED	Dtsp..csWFKlTIPaG+KYDKpWLLs.lQshCSlPFsPVcFHh-pp+ApFFVEsussApALKplSt+IhDc-spKlsIhhsPsssP.pl	.............tsWFKl.TIPaGpKYDKpWLls..I.Qu.p.CSVPFsPl..........-.FHY-ps.c.ApFFV-DussAsALKslshKI.hD.c.-.sp+IsIhVs.sussP..................	0	21	29	62
+8995	PF09163	Form-deh_trans		Formate dehydrogenase N, transmembrane	Sammut SJ	anon	pdb_1kqf	Domain	Members of this family are predominantly found in the beta subunit of formate dehydrogenase, and consist of a single transmembrane helix. They act as a transmembrane anchor, and allow for conduction of electrons within the protein [1].	20.60	20.60	20.90	20.90	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-7.95	0.72	-4.46	40	1298	2009-01-15 18:05:59	2006-08-17 10:52:16	6	17	834	2	134	480	11	44.10	58	14.80	CHANGED	ISssVpLWK.GlhKPLushuhuussluuhhHYlslGPNcss....----	..IspoVphWK.GhhKPLAAsGFhATF..AutIFHYlGlGPN+ts....----p.......	0	20	52	94
+8996	PF09164	VitD-bind_III		Vitamin D binding protein, domain III	Sammut SJ	anon	pdb_1kxp	Domain	Members of this family are predominantly found in Vitamin D binding protein, and adopt a multihelical structure. They are required for formation of an actin 'clamp', allowing the protein to bind to actin [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.39	0.72	-4.36	6	46	2012-10-01 21:15:37	2006-08-17 11:02:52	5	2	31	9	23	56	0	67.30	58	14.43	CHANGED	ELCADYSENTFTEYKKKLu-pLRsKhP-Aosp-Ls-LVsKRSDFASpCCSINSPPlYCsSpIDAElps	.....................ELCADYSENTFTEYKKKLuEpL+sKhPDAoss-LtcLV-+RSDFASpCCSINSPPLYCsSplcs.ht............	0	1	2	6
+8997	PF09165	Ubiq-Cytc-red_N		Ubiquinol-cytochrome c reductase 8 kDa, N-terminal	Sammut SJ	anon	pdb_1l0l	Domain	Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain [1].	22.90	22.90	23.70	22.90	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.42	0.72	-3.66	16	86	2009-09-11 00:16:57	2006-08-17 11:15:50	5	2	67	47	31	89	0	73.30	47	27.43	CHANGED	hSlsuRSGsluPYlpATopuVAusLK.PLlPusl.hpuEKlllcs++shLs+ESLsGphPppuLtsosu.lsususVR	........hSlAARSGsFAPhLpATSpuVAGsL+.P.LltusV....sssEpslLDsK+PFLsRESLSGQus+p.sLsASVG.lNsPAoVR.......	0	9	12	18
+8998	PF09166	Biliv-reduc_cat		Biliverdin reductase, catalytic	Sammut SJ	anon	pdb_1lc0	Domain	Members of this family adopt a structure consisting of four alpha helices and six beta sheets, in an alpha-beta-alpha-alpha-alpha-beta-beta-beta-beta-beta arrangement. They contain a catalytic active site, capable of reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor [1].	21.00	21.00	21.00	23.40	19.20	20.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.43	0.71	-4.07	4	55	2009-01-15 18:05:59	2006-08-17 11:33:23	5	3	38	7	31	52	0	111.70	61	38.98	CHANGED	-FKtLK+ElpGKpL.EGsLHFTGGPLcts.FGFPuFSGIARLTWLVsLFG-LoVTSAThEEcKEppY.KMTApLhTppc+PLTWIEERGPGhtRsKHIcF+FpssoLsplPuusR	................................EFthLKKEVsGK-LlKGoLhF.TuGPL-Ep+FGFPAFSGIuRLTWLVsLFGELSlsSATLEEcKEcpYhKMTVpLcTpsK+PLTWIEE+GPGLKRs+alsF+FcSGoLEslPsss.h.............	1	2	3	10
+8999	PF09167	DUF1942		Domain of unknown function (DUF1942)	Sammut SJ	anon	pdb_1lmi	Domain	Members of this family of bacterial proteins assume a beta-sandwich structure consisting of two antiparallel beta-sheets similar to an immunoglobulin-like fold, with an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of these beta-strands form an antiparallel beta-sheet. The exact function of this family of proteins is unkown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation [1].	20.70	20.70	20.80	23.30	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.59	0.71	-4.38	13	123	2009-01-15 18:05:59	2006-08-17 11:45:15	6	2	76	1	32	109	0	122.70	51	64.17	CHANGED	ApssspplGpsucLls..GsVVQsWTVSDLKPSoDsIP.YtltGpLWEATATscAlsGsVTPIVSNhNARAssGpoYRVLapVATPpGlNPuTLuQGppoTGKlYFDV.TGssPsSVVY.NsGupDlllW	....................s..PhstphGophphsD..ssGtVV.uWpVSDL+sSossIP.YsltGplWEATATspAlpGoVTPsVupFNARsssG.sYRVLap.sAsPsslssATlsQGppoTGKIYFDV.TGssPshVsh.NsG..hpDLLlW........	0	1	18	27
+9000	PF09168	PepX_N		X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal	Sammut SJ	anon	pdb_1lns	Domain	Members of this family adopt a secondary structure consisting of a helical bundle of eight alpha helices and three beta strands, the last alpha helix connecting to the first strand of the catalytic domain. The first strand of the N-terminus also forms a small parallel beta sheet with strand 5' of catalytic domain. The domain mediates dimerisation of the protein, with two proline residues present in the domain being critical for interaction [1].	25.00	25.00	28.60	28.50	21.30	19.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.07	0.71	-3.98	24	510	2009-01-15 18:05:59	2006-08-17 11:56:45	5	3	489	1	52	340	1	141.70	47	19.29	CHANGED	MKhN..QFualssshcpthpELppluF....hptpss.ps.LcsFlp+hahphps...psttLsplhAsscpDLhsFhpoc.pplotclFYslALQLLGFpsthDFsh.DshshhcchshP.......hhssppllpuhYpLLsTRoKsGpoLlDpLsucGa	...M+aN..QaSYlshsh-phlpELcplGFp...hpspsstKcsLEsFLR+hFhpaps....osasLo.LAA-pcTDLLoFFpS-.pcLTs-lFYsVAhQLLGFphhVDF-..DspsFh+csuFP......hhasp..LI-sLYpLLNTRTKpGpTLIDpLVScGL.........	1	7	20	34
+9001	PF09169	BRCA-2_helical		BRCA2, helical	Sammut SJ	anon	pdb_1iyj	Domain	Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (Pfam:PF09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [1].	25.00	25.00	25.00	25.10	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.13	0.71	-4.74	5	134	2009-01-15 18:05:59	2006-08-17 12:55:12	5	28	95	3	83	142	1	148.40	43	7.01	CHANGED	DLhusLps......ARDlQ-MRIKKKpRQplhPQPGSLYLsKoSslsRISLKuAVGccsPStpSs...cQLYsYGVSK+CIcVNScNAESFQFclp-FFuK.EsLpsGcGIQLADGG..WLIPoNDGKAGKEEFYRALCDTPGVDPKLISctWVYNHYRWIVWKLAAMEpuFP+cFANRCLTPEpVLLQLKYRYDlEIDpS	....................................................................................................................................................................h.t...............h............ph..htl..t.....h.tlpstsu....apF...paht.....t..h..........t.tuh.htDus.....hl.l.s.ppGp..s.Gt.cEFhcAlhsss...GVDPpLloctWVhNHYRWIlWKLAu..M..Eh.sFPc...c...h...us...+.sLoP-pVLhQLKYRYDhElDp.....................	0	36	46	64
+9002	PF09170	STN1_2	DUF1879;	CST, Suppressor of cdc thirteen homolog, complex subunit STN1	Mistry J, Sammut SJ	anon	pdb_1wj5	Domain	STN1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required for protecting telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity on their own. In addition to telomere protection, the CST complex probably has a more general role in DNA metabolism at non-telomeric sites.	21.90	21.90	24.90	24.20	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.27	0.71	-4.50	6	63	2009-01-15 18:05:59	2006-08-17 12:57:40	5	4	43	1	32	51	0	165.20	48	47.30	CHANGED	DPshslQIARMLELPplYRpVYDpPFchPsptcs..Eutsspt.ls.stLlShLSEKlKEFLhEp+lpsFYQpELE.hV-SLlulASpPV...ssuDQ.p.tcoSsSpQl+plFKEAlplLQ-cGhlFQKcpspDEVYpVTcQDKDLHptIhcII+EDC++pKHhEKGCHhLHILsCVRhs	.......DPshslQIARMLELPplYRclYDpPFp.sshtpp...cuhs.s.sss.lshssL.sshL.....SEKhK-FL..hE.s+VpoFY....QpELE.hV-SLlslAspPl........sssucQ...sh.ps.sosSptI+slFKpAlplLQ-cGlVFQKssu.Dpl.YaVTccDK-LH+pIhcIIpEDCQKPpHsEKGCHFLHILuCsR.p....................................	0	5	7	14
+9003	PF09171	DUF1886		Domain of unknown function (DUF1886)	Mistry J, Sammut SJ	anon	pdb_1xg7	Domain	This domain is predominantly found in the Archaeal protein N-glycosylase/DNA lyase.	21.30	21.30	21.60	21.30	19.80	21.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.58	0.70	-5.35	19	68	2009-01-15 18:05:59	2006-08-17 13:00:51	5	1	58	4	53	72	1	219.20	28	79.14	CHANGED	ls-hlpclul-tsphlEcp.DsQacAlppLhcph.spthhspLllhNALVSYpLou+GE-aWhpFucY......Fupp....pspslscsahpFLppSphN+RhlcsKl+Rlc+hpsalpsL.t..s...ha.pshstlhppLu+hLsuctpsKTlVFAlKMhsYAhRsshsh.hshPh-IPIPlDhRltplThp......................hpp-tshchWsplA+couIPPLHlDollW.lhGtsh.htp..tp..........ltcclttlhc	....................................................................................................................................hphlpplslchhphhEcp.D.QahslppLhpph..st..............thhhhLslhNuLlSYpLss+G.E.c.aW..Fuca.......aspp.............pshhctahp.Fl.po.htchhhptKl+Rlp+h..hsh.h...pl.....p...hh.pshtthhppLuphlssc.ptKTlVFAlKMhsY...uhchs.s..h....hsh-IsIPlDhRlsphThp..h...............................hppctshphWpplu+p.....u.s....IPPlHlDolLW.lhGtth..h.p.......................t...................	0	16	26	38
+9004	PF09172	DUF1943		Domain of unknown function (DUF1943)	Sammut SJ	anon	pdb_1lsh	Domain	Members of this family adopt a structure consisting of several large open beta-sheets. Their exact function has not, as yet, been determined [1].	23.10	23.10	23.60	23.20	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.78	0.70	-5.55	71	578	2009-01-15 18:05:59	2006-08-17 13:03:58	6	29	211	1	253	586	0	275.40	18	14.04	CHANGED	+aS+shchshassshhhGs...usps.hI.sssohLP+slhhphpshhhGt..shslhElGhRsEGlcchltc................................................................................ts...tpphpclpphlpt.lpph+shs.......ppsh.............ushYl+hhGpElsFhslsc.........phlcphhphh..............pphlpp.......lh.pGhphp..hs+shlhh-schhhPTshGlPhcluhhssul.suhpspsp.hslps.h.p.h..........pshphcschpPSluhphhuhhGlsss.hhps..ulphcsplpstsshchpsclshptt.phclph...ss..pp.pclhsh..p.scsasl	..................................................................paSpshp....hshh.p...h........hG....s....thph.hIhsssohlP+thhhphpt.hhGh..shshhEluh..cs..cuhcphltph.........................................................................................t....tp.....tpthpp.lt.p..hl...ph.hpphcth........ts..............up.h.al+hhGp-htahshsc.............phl.pph.hphh..................tphlpp...lh.....puhphp.......ht..p.hhhh-sphhh..PTshGlPhp.hshhsssl.sshp.s.p..sp..hphps...t...................tphphph..phpPohuhphhsh..hGh.ss..hhps....ulthpsph..pt.ths...hchphphpht....t..p.....hclph....ss....pp......pl..hph.psp.hh.................................................................................	0	84	117	208
+9005	PF09173	eIF2_C		Initiation factor eIF2 gamma, C terminal	Sammut SJ	anon	pdb_1kk1	Domain	Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA [1].	22.00	22.00	23.10	23.40	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.95	0.72	-3.94	36	581	2009-09-10 18:26:08	2006-08-17 13:07:42	6	11	483	29	368	573	91	89.20	51	18.91	CHANGED	asclcl.paaLLcRllGs+p......thKVppLppsEsLMlNlGSsoTsGhVsulK..sDhsclpLspPVCsphG-.+lAlSRRlsp+WRLIGWGpI	..................asElEl.saaLL+RLLGV+ot...........stKtuKVpKLs+sElLMlNIGShoTGG+VsulK........sDh.A+l.tL.TsP.VCT-hGE.KlA.LSRRl-....KHWRLIGWGpI........	0	119	204	294
+9006	PF09174	Maf1		Maf1 regulator	Mistry J, Wood V	anon	manual	Family	Maf1 is a negative regulator of RNA polymerase III [1][2].  It targets the initiation factor TFIIIB [3].	21.60	21.60	23.00	23.50	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.08	0.71	-4.42	21	367	2009-01-15 18:05:59	2006-08-17 13:09:05	5	7	291	1	253	346	4	169.50	32	62.03	CHANGED	slhupl-saos+hstsc+plhpphppp.pttt.ps.s.s.....................t.........................sshsslscpsSR+sLsYLIusLNtsa.PD.YDFS.slcspsFp+p.ohppVhsplsssL.slspp.h............................shhtplWpslc-pls..lp-C-IYoYs..Pp.ssDPa.sEcGslWShsYFFaNKKhKRllahp	............................................................................................................................hhsth-.aosKhsus-+chh+ph..ppp..h..p..sp....p..p.s......................................................s......tt....t.t....................................................sshusL.s...pp.s.SR+ThhYLIuTLNtua.PD.YDFS.sh+s..pcF..............p+E.s...hphlhstlsssLh..shs.tp.........................................................................................................shhsphWpsl-cphs..Lp-...CslYoYs..P...s.sDPa..t-p.....G...s....lWShpYFFaN+chKRlsah......................................	1	94	148	216
+9007	PF09175	DUF1944		Domain of unknown function (DUF1944)	Sammut SJ	anon	pdb_1lsh	Domain	Members of this family adopt a structure consisting of several large open beta-sheets. Their exact function has not, as yet, been determined [1].	20.90	20.90	23.70	21.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.02	0.71	-4.62	30	201	2009-09-11 17:00:47	2006-08-17 13:15:43	5	9	70	1	58	162	0	155.20	37	12.32	CHANGED	PshsllsRAVRuDpKhtGYQlusYhD.+ssuR..lQlIluslu-ssNW+lCADuslLS+HK.lhA+luWGtEC+pYssplpAETGhl.GspPAsRl+lsWs+LPpsh+...cYuKtlscYl...sssAhhsGlspp+p+Nsp+QlplTlsssSp+olslllKsPchTlYKhultLP	...........................................................................PshsllhRAlRuDpKh.GYQlssYhDpssuR...lQllluslu-ssNWKlCADuslLSpHK....spA+lsWGtEC+.pYps.hpA.EoGhl.uppPAsRl+lpWp+lPphhp...phu+pltcal....ssAh.hGhp..p+scNsp+plplosAhsSp+olsllh+hPchTha+hslhLP......................................	0	0	11	41
+9008	PF09176	Mpt_N		Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	Sammut SJ	anon	pdb_1lu9	Domain	Members of this family adopt a alpha-beta structure, with a core comprising three alpha/beta/alpha layers, in which each sheet contains four strands. They are predominantly found in prokaryotic methylene-tetrahydromethanopterin dehydrogenase, which catalyses the dehydrogenation of methylene-tetrahydromethanopterin and the reversible dehydrogenation of methylene-H(4)F [1].	19.10	19.10	21.30	24.80	17.80	15.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.70	0.72	-4.12	17	128	2009-01-15 18:05:59	2006-08-17 13:40:18	6	9	85	6	52	135	48	76.40	47	27.55	CHANGED	PFDlNMAlDAGa-slhsYusVp.p-VpsLVQDuIFSRuPpshp+TulFIGGpDhshAhshLcsAKcuhlPPFclSV..hsDPu	.PFDlshAhDAGh-hlhsYssVp.spVsuLsQDuIFoRuPpshtcTuIFIGG+DsthAhDMLcsA+cuhhsPFclSV..hADPu.	1	16	37	44
+9009	PF09177	Syntaxin-6_N		Syntaxin 6, N-terminal	Sammut SJ	anon	pdb_1lvf	Domain	Members of this family, which are found in the amino terminus of various SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that they regulate the SNARE motif, as well as mediate various protein-protein interactions involved in membrane-transport [1].	24.90	24.90	25.00	25.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.11	0.72	-3.58	43	417	2009-01-15 18:05:59	2006-08-17 14:06:41	6	8	263	7	271	389	2	95.20	29	35.74	CHANGED	DPFa.Vpc-Vpculsph....cslappatphhssss.................chtphpp-LpsslpslchsLcDLcculsl.....spps...Pp+a.slsppElscR+palpphcsplpplc	..............DPFa.....VppE.Vpculsph....culappahclhppss.....................t..Ehp.tppELcssLpolchsL.-DL-c.ol..pl...................scps.....Pt+.a.slstsElspR+palpshcpplpphc....................	0	80	146	214
+9010	PF09178	DUF1945		Domain of unknown function (DUF1945)	Sammut SJ	anon	pdb_1lwh	Domain	Members of this family, which are predominantly found in prokaryotic 4-alpha-glucanotransferase, adopt a structure composed of six antiparallel beta-strands, four of which form a beta-sheet and another two form a type I' beta-hairpin. The role of this family of domains, has not, as yet, been defined [1].	21.20	21.20	29.40	28.10	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.52	0.72	-4.08	2	9	2009-09-11 06:49:26	2006-08-17 14:23:45	5	1	8	4	2	8	2	49.40	71	11.17	CHANGED	AplEFLCKE-KhL.VYRLhD-t+SLKVhHNLSstEhVFEGV+hpPYpTEVl	.......AKlEFLCKE-KFL.VYRLYDDQ+SLKVFHNLSGEEVVFEGV+h+PYKTEVV.	0	1	1	2
+9011	PF09179	TilS	DUF1946; 	TilS substrate binding domain	Sammut SJ, Bateman A	anon	pdb_1ni5	Domain	This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.10	0.72	-3.96	123	1699	2009-01-15 18:05:59	2006-08-17 14:53:22	6	7	1681	3	357	1331	279	68.00	29	15.99	CHANGED	Lslss..Ltpho.scppplLRhWLpth...sh.thPoptpLpplhpplhtup...tDupsplph.s...shplRRapscLah	...........Lplss..hhshS.ss+pttllRtWLstt...sh..shP.......S..pspLpclhpplt.hA+...pDussplph.s......shplRRapspLah.............................	0	94	204	286
+9012	PF09180	ProRS-C_1		Prolyl-tRNA synthetase, C-terminal	Sammut SJ	anon	pdb_1nj1	Domain	Members of this family are predominantly found in prokaryotic prolyl-tRNA synthetase. They contain a zinc binding site, and adopt a structure consisting of alpha helices and antiparallel beta sheets arranged in 2 layers, in a beta-alpha-beta-alpha-beta motif [1].	20.90	20.90	21.10	21.00	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.60	0.72	-4.05	82	1277	2009-01-15 18:05:59	2006-08-17 15:23:59	6	39	1155	18	562	1221	419	73.60	33	12.63	CHANGED	a--h............ppsl.spt....shlhssWCGs.tcsEpcIKcco.....................sApshCl.Ph..-........p.tpsspCl...hsG.+sAp..phshFu+uY	............................................a--hpptl..pcs........salhu.WCGs..tcCE-cIK-co...........................................uAssRCI.Pa-.....................ttptsspCl.....hsG..+sAc..phshFu+uY..............	0	222	375	492
+9013	PF09181	ProRS-C_2		Prolyl-tRNA synthetase, C-terminal	Sammut SJ	anon	pdb_1nj8	Domain	Members of this family are predominantly found in prokaryotic prolyl-tRNA synthetase. They contain a zinc binding site, and adopt a structure consisting of alpha helices and antiparallel beta sheets arranged in 2 layers, in a beta-alpha-beta-alpha-beta motif [1].	25.00	25.00	78.40	77.10	19.50	17.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.08	0.72	-4.05	4	16	2009-01-15 18:05:59	2006-08-17 15:24:53	5	1	16	4	10	17	0	65.10	57	14.15	CHANGED	ITll-NhcsD......clKtsLSEpKGlILVPacEsIYNEEFEEhIDASVLGpTpYcGKcYISIA+TY	.........ITll.sh....-s-.....-clKphLsEp+GlILIPacEsIYNEEhEEpl-ASVLGpTpYcGKcYIuIA+TY	0	1	2	7
+9014	PF09182	PuR_N		Bacterial purine repressor, N-terminal	Sammut SJ	anon	pdb_1o57	Domain	The N-terminal domain of the bacterial purine repressor PuR is a winged-helix domain, a subdivision of the HTH structural family. It consists of a canonical arrangement of secondary structures: a1-b1-a2-T-a3-b2-W-b3, where a2-T-a3 is the HTH motif, a3 is the recognition helix, and W is the wing. The domain allows for recognition of a conserved CGAA sequence in the centre of a DNA PurBox, resulting in binding to the major groove of DNA [1].	24.60	24.60	24.80	24.60	24.50	23.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.21	0.72	-4.36	37	1165	2012-10-04 14:01:12	2006-08-17 15:54:53	5	2	1161	8	145	506	0	68.50	57	25.17	CHANGED	+Rs-RllshT+hLl-pPpcLlsLshFu-hapuAKSoISEDLsIlKcshcchuhGpl-TlsGAAGGV+YIP	.....+RS-RhVshopYLlspPpcLlsLshFA-+YpuAKSSISEDlsIIKcsFccpplGplpTlsGAuGGVpahP....	0	52	92	118
+9015	PF09183	DUF1947		Domain of unknown function (DUF1947)	Sammut SJ	anon	pdb_1q7h	Domain	Members of this family are found in a set of hypothetical Archaeal proteins. Their exact function has not, as yet, been defined.	22.50	22.50	22.60	23.00	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.19	0.72	-4.21	7	27	2009-01-15 18:05:59	2006-08-17 16:16:08	5	2	27	1	13	24	4	64.70	45	42.26	CHANGED	pRHhlScK-tKhhhschcp.YGIDlou.tclEVuppK+phhYalssh.shFs-.pLIPTLhhlpphp	.QRHlhSpK-tKhhlsKlKp+Ys.IDlSs.s+lElGKEKKcs.aYYlsslL..u..F.Fs-...LIPTL.ChlhKhp...........	0	3	5	10
+9016	PF09184	PPP4R2		PPP4R2	Mistry J, Wood V	anon	manual	Family	PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex.  It has been shown to confer resistance to the anticancer drug cisplatin in yeast [1], and may confer resistance in higher eukaryotes.	25.00	25.00	29.60	29.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.10	0.70	-4.86	15	305	2009-01-15 18:05:59	2006-08-17 16:18:36	6	3	245	0	201	303	0	204.50	22	50.95	CHANGED	shcpl.phhccFpchtpK.Elss.L-paLsclA+T.G-ThhsWsphKshhpaKlppVhcDFp....................tpsP..tchssssNV-shshE-MKcplLcllssFNu......hPFTIQRlCELLs-P..p+pY..sclDKFlRAlEKNlhVVSolpPssc+ssus......stsphsulh..................hststssahcc.t.............Vsssusscshs......csp..huss.ssNshssospscspphpp..-ccss.sussps-ss.s..sslt......sc+s-c--sppt-u-..........hEscphc.-c---Esc--p-pssss-	...............................................................................................................................t....................................................h..hh...h..h....ph..........................................................................p..........p................hpp.h...pphl.h.....p.h.l.s.sFss.......sPFTIQRLCELlhcP..p+p.Y.....sshsKal+AlEK...........slhVsS....s....h....t..........s......t...................................t........................................................................................................................................................................................................................................................................................s................................................................................................................................................................	0	64	106	162
+9017	PF09185	DUF1948		Domain of unknown function (DUF1948)	Sammut SJ	anon	pdb_1q8c	Domain	Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with one central alpha-helix surrounded by five others, in a NusB-like fold. Their function has not, as yet, been determined [1].	25.00	25.00	292.80	292.60	23.90	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.78	0.71	-4.52	2	4	2009-01-15 18:05:59	2006-08-17 16:25:49	5	1	4	1	2	4	16	140.00	87	88.33	CHANGED	LTRTQRRIAlVEFIFuhLFFLPKpA-.IQAsFL-YDs.ER.LN-WQK.IVKsFSEphhpF.chIEpQQ.+NQhElQoKYNKlSGKKlDLLTpAVlLCALSEQ+ApsTDKPLLISEALLIMDHYSQssEKKQTHALLDKLL	LTRTQRRIAIVEFIFATLFFLPKTADQIQAAFLDYDVPERPLNDWQKEIVKVFSERCVEFIELIENQQQRNQAEVQSKYNKVSGKKVDLLTKAVILCALSEQHAQATDKPLLISEALLIMDHYSQVPEKKQTHALLDKLL	0	1	1	1
+9018	PF09186	DUF1949		Domain of unknown function (DUF1949)	Sammut SJ	anon	pdb_1vi7	Domain	Members of this family pertain to a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement [1].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.33	0.72	-4.36	181	2861	2012-10-02 20:07:24	2006-08-17 16:36:13	6	4	2841	2	493	1750	45	55.80	23	26.73	CHANGED	lphcYsphuplcphLp...p.ts.htlhcppYssp..Vplpltlstsphpshpptls-hosGp	......lphsYsphsplcthLt....p.ps.htlhssp.Yssp.....Vphpltl..s..tsc..h..pshpstLs-hopG...................	0	132	288	408
+9019	PF09187	DUF1950		Domain of unknown function(DUF1950)	Sammut SJ	anon	pdb_1vk5	Domain	Members of this family pertain to a set of functionally uncharacterised hypothetical eukaryotic proteins [1].	25.00	25.00	107.40	25.60	17.60	17.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.71	0.71	-3.96	3	18	2009-01-15 18:05:59	2006-08-17 16:49:10	5	2	10	3	11	22	0	110.80	59	64.70	CHANGED	LLR+.AEMYQ-YMKQlPIPo+R.GSlIPsTTWlGLGpSMKQLYGQPLHYLTNVLLQRWDQSRlGSDsEH+PLDSIIHPoKAEATIWlVEElHRLTTSoQHlAoLWtSDPMYHAFIDPIFPc	...llRR.AEMYQ-YMKpIPIPspR.GShIPFooWhGLu+SlKQLYsQPLHYLTNlLLKpWDQ.RlGS--Ep+sLDsIIHPsKAEATIWlhEElHRpToSphHlApLWtsDPMYa.uFlDsIFP......	0	1	7	9
+9020	PF09188	DUF1951		Domain of unknown function (DUF1951)	Sammut SJ	anon	pdb_1tm9	Domain	Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with a buried central helix. Their function has not, as yet, been determined.	24.40	24.40	26.40	30.50	23.70	24.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.92	0.71	-4.22	2	7	2009-01-15 18:05:59	2006-08-17 16:57:27	5	1	7	1	3	4	0	136.60	49	96.37	CHANGED	ME.NNlKEpLlShFppACSoHpERLDFICSsRESDTFSsVDVPLtPIKsIIEIsKsEppQhEIhKlAlpNIKTLSoVG.oGQYhASaFSTpsEsAIIFCl.YFLYHFsFL+DpNKKQllK+AaEslA-pIADYLNEN	..............EchlosFpphhopctp+hDFIpSVhEsDshuNh-hPht.lpplh-lhhNE.spp.hhphhIpshhTh.Tsh.php.lhShFppppplh.hFCl.YhLa+.sF.aD-sc+phlp+hhpslAcclh-hLs....	0	2	2	2
+9021	PF09189	DUF1952		Domain of unknown function (DUF1952)	Sammut SJ	anon	pdb_1v8c	Domain	Members of this family are found in various Thermus thermophilus proteins. Their exact function has not, as yet, been determined.	21.20	21.20	21.90	21.80	18.60	17.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.61	0.72	-4.28	2	11	2009-01-15 18:05:59	2006-08-17 17:05:56	5	2	11	4	4	11	0	77.60	56	49.80	CHANGED	GFERTFGAFPPWLLERYLEEWGGTREGEGVYRLPGAVVRFREVEPLKVGSLSIPQLhVEVEGEtuEtWFERIAhAASR	........htppFGAhPPWLLE+YLpEWGGp+-GEGsYRLPGAhVRFRElEPL+VGSLSIPQLcVEVEGEEA..EtWFERIAhAASR........	0	1	3	4
+9022	PF09190	DALR_2		DALR domain	Sammut SJ, Bateman A	anon	pdb	Domain	This DALR domain is found in cysteinyl-tRNA-synthetases [1].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.11	0.72	-3.72	124	4263	2012-10-02 19:03:26	2006-08-17 18:00:12	6	6	4170	6	980	3173	1201	63.60	30	13.64	CHANGED	cFtpAM-DDFNTspAlulLF-LA+clNp..........ttt.....shptt....pth..t......stLppL....uslLGl..lpp........ss..csal	..........pFhpAMsDDFNTspAluslF-hu+p.lNp...............pst.........sttst...........pth.....t......................stlc.ph...........sslLGl..ltpt..............................................................................	0	339	644	840
+9023	PF09191	CD4-extracel		CD4, extracellular	Sammut SJ	anon	pdb_1cid	Domain	Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens [1].	25.00	25.00	25.40	49.20	21.40	24.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.46	0.72	-4.03	11	88	2009-01-15 18:05:59	2006-08-18 08:50:08	5	16	45	8	18	96	0	105.90	61	25.33	CHANGED	QKsSsTVYtKEGEQsEFSFPLsFp-ENL..pGELpW.QActASSsQSWITFoLcN+KVSVpKsppslKLQMpEsLPLpLTLPQsL.QYAGSGNLTLsLs..KGpLHQEVNLVV	....QKsSsTVYKKEGEQVEFSFPLsFptEpL.....oGELhW.Q.AEtASSupoWITFsLcN+cVSVpclppD.KLQMucpLPLpLTLPQALPQYAGSGNLTLsLs..pGK.LHQEVNLVV..................................	0	1	1	2
+9024	PF09192	Act-Frag_cataly		Actin-fragmin kinase, catalytic	Sammut SJ	anon	pdb_1cja	Domain	Members of this family assume a secondary structure consisting of eight beta strands and 11 alpha-helices, organised in two lobes. They are predominantly found in actin-fragmin kinase, where they act as a catalytic domain that mediates the phosphorylation of actin [1].	20.30	20.30	21.40	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.79	0.70	-5.42	7	59	2009-09-11 11:13:43	2006-08-18 09:14:55	5	5	31	2	47	61	0	252.30	26	38.15	CHANGED	sssuh..slsppthhhssIpsIsWssL.slchl-hu....................ssslhhlhThps.......t..p.....................................plllKuoso...Isp-sauSlLphlLtlPlPchRllc.ss.EappMopsLh.....tohpscpLhchIpoclpcsa.....hLIMEYhp.GpphscLspp......paFuspt.uc++hpQLGplluhDlhs......................................................NN.s+hP...ht.ssps.huNIlhh-pPp..GhhhsllsSslp...slssS.FshtY...................+pahsRl+.lLaolhQ...pPstEShQ...............lpphR-hl.pppshclsppSs...hplQp.....GIspGl	................................thttssh.......c.pshsWs...lpulcpocpu............................SuGVl..FhshFps...............t...........................................usVlKhu.so...hpuEhhuhcluchLG...lpsPpsRll.cpss........Eatphpcuhp.....huspp..s-p.ltchhp..pEl.hcuh.....lhlMpYlp.G.ps..Lh-.sps.............Fpsp....p.upcphpsLG+llhLDlll..........................pNpDRLP.t.LtWc..GNsuNlll.scc............h.tsh......t.....................................p.hh.pht....t....................................................................................................................................................	0	24	38	43
+9025	PF09193	CholecysA-Rec_N		Cholecystokinin A receptor, N-terminal	Sammut SJ	anon	pdb_1d6g	Domain	Members of this family are found in the extracellular region of the cholecystokinin A receptor, where they adopt a tertiary structure consisting of a few helical turns and a disulphide-crosslinked loop. They are required for interaction of the cholecystokinin A receptor with it's corresponding hormonal ligand [1].	20.30	20.30	20.70	24.70	20.10	17.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.33	0.72	-4.08	5	39	2009-01-15 18:05:59	2006-08-18 09:29:54	5	1	27	1	20	37	0	47.20	73	11.41	CHANGED	MDVVD.SLLsNGSNITP.PCELGLENETLFCLDQP+.PSKEWQPAVQILL	..MDVVD..SLLsNGSNITP.PCELGLENETLFCLDQPp.PSKEWQPAVQILL	1	1	1	3
+9026	PF09194	Endonuc-BsobI		Restriction endonuclease BsobI	Sammut SJ	anon	pdb_1dc1	Domain	Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence CYCGRG (where Y = T/C, and R = A/G) and cleave after C-1. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates [1].	25.00	25.00	53.90	53.90	21.60	17.50	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.92	0.70	-5.49	4	29	2012-10-11 20:44:45	2006-08-18 09:44:51	5	2	22	2	5	29	0	225.10	41	98.98	CHANGED	hPYp.HLpSsDDLhToYEthRAGFlALALEKN+RuTPaltcARALKltASpAcsPpDLLplcDIpsuLLsASGlSDKAtsaLp.pDKsEAIpsLIpNFLEPAGEpFVEELVaRFLLhRGDoLGGoMRNlGGsLAQpKhTRuIISsLslAsIuY+WLcSpsKp...Wh-ts-DDs-lElhlRGlSWp.pGcsRTlhYNlsVPlV.+pNlDlCLFsCcssplpsQ....pshpssshYIALGELKGGIDPAGADEHWKTApoALsRIRsAFs+tuhpPaTFFIGAAIE+pMAcEIWcQLpoGhLTNAANLTpssQluSlsRWhhpL	..........................spDLhTshpthhsGF...A.p+.t+usPalt.Achhp..hpp.hpp..pLhp..tlp.hllsAshhScKuhtaLp.p.p.chIptLI.sF.c.ssppalppL.h+aLLhpGDoLGG.MRNhsG..ApphhsphllstL...shs.ph....ppp................................................l.ppslDhhlhpht.tth........h....p.hlshGELKGGIDPAGADEHWKTApsALsRIhpAF.phthp.PhhhFlGuAIEhtMu.EIap.LppthLssAANl.p.pQlhpl.thhh...................	0	0	5	5
+9027	PF09195	Endonuc-BglII		Restriction endonuclease BglII	Sammut SJ	anon	pdb_1dfm	Domain	Members of this family are predominantly found in prokaryotic restriction endonuclease BglII, and adopt a structure consisting of an alpha/beta core containing a six-stranded beta-sheet surrounded by five alpha-helices, two of which are involved in homodimerisation of the endonuclease. They recognise the double-stranded DNA sequence AGATCT and cleave after A-1, resulting in specific double-stranded fragments with terminal 5'-phosphates [1].	21.60	21.60	22.40	22.00	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.89	0.71	-4.77	20	74	2012-10-11 20:44:45	2006-08-18 10:00:22	6	1	72	10	33	86	41	177.60	21	84.63	CHANGED	pApsllpp.phssthpEltpsLtshslphsclpsuutscptsp.hh.........cchltscGWtpch.............................................hh.......................sh-pps...........................pclDahK.........sslulElpauNhs.hh.pDLhp..aphhaspsh......IcVGllls.spshpc.................................................................chusussaaE+lhpcl.ptuc.ss.slPllllGls	............................................................................................................................................................................uttllt...thsp.hpEl.psltsh.php..h......tp.httss..tpptt..ht.hh...............ccthhtp.GW.pct.............................................ph..................................t..............................pplDahK.........sclulElpasshshhh.pDLhs....aph..h..a..p.tsh......IslGllIs...tspp.hpp............................................................phusussta-+hh.cl.ctup..ss.ssPllllGl...............................	0	12	27	31
+9028	PF09196	DUF1953		Domain of unknown function (DUF1953)	Sammut SJ	anon	pdb_1iv8	Domain	This domain is found in the Archaeal protein maltooligosyl trehalose synthase produced by Sulfolobus spp. Its function has not, as yet, been defined.	25.00	25.00	41.80	122.20	22.90	21.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.19	0.72	-4.27	2	2	2009-01-15 18:05:59	2006-08-18 10:11:54	5	1	2	2	1	3	0	64.50	49	9.06	CHANGED	EYKsLcLpcGLCGFhRhsKlLVIlKT...lNhchclE.su.YTDVlTsEpl+tcVplscLPhILV+	EYKsLcLpcGLCGFhRhsKlLVIlKT...lNhchclE.su.YTDVlTsEpl+tcVplscLPhILV+	0	0	0	1
+9029	PF09197	Rap1-DNA-bind		Rap1, DNA-binding	Sammut SJ	anon	pdb_1ign	Domain	Members of this family, which are predominantly found in the yeast protein rap1, assume a secondary structure consisting of a three-helix bundle and an N-terminal arm. They contain an Arg-Asp-Arg-Lys sequence that interacts with an ACACC region in the 3' region of the DNA-binding site [1].	22.40	22.40	22.80	22.40	22.30	20.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.56	0.72	-3.49	19	53	2012-10-04 14:01:12	2006-08-18 11:12:12	5	4	48	3	30	86	0	114.20	39	17.31	CHANGED	KFTA--DYpLshtlpc.hhpchhphsssputshhps.c...h.h.tph.h.........................tpFFcph.....................ucppP..sHTpsuWRDRaRKFlhsaG.lccYIcYYEppptsucpPcshKNhTs	.........................................................................................KFoA-EDYtLshslpcphhc-hhphDs-supshlpstct.shlscpphs.........................................sls+pFFcpa.....................uccas..sHTcsuWRDRFRKFlhsYG.lccYIpYYEspptpscpPEPM+NlT..........................	0	5	17	28
+9030	PF09198	T4-Gluco-transf		Bacteriophage T4 beta-glucosyltransferase	Sammut SJ	anon	pdb_1jix	Domain	Members of this family are DNA-modifying enzymes encoded by bacteriophage T4 that transfer glucose from uridine diphosphoglucose to 5-hydroxymethyl cytosine bases of phage T4 DNA [1].	25.00	25.00	56.40	55.20	17.90	14.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-7.91	0.72	-4.63	2	4	2009-01-15 18:05:59	2006-08-18 11:21:40	5	1	2	22	0	6	0	38.00	82	13.98	CHANGED	MKIAIINMGNNVINFKTVPSSETIYLFKVISEMGLNVD	MKIAIINMGNNVINFKTVPSSETIYLFKVISEMGLNVD	0	0	0	0
+9031	PF09199	DUF1954		Domain of unknown function (DUF1954)	Sammut SJ	anon	pdb_1m4v	Domain	Members of this family are found in various staphylococcal toxins, and adopt an OB fold, wherein the domain folds into a five-stranded beta-barrel. The exact manner in which they confer pathogenic properties to the protein has not, as yet, been determined [1].	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.82	0.72	-3.78	21	1637	2009-01-15 18:05:59	2006-08-18 11:49:10	5	2	161	29	14	384	0	83.10	38	33.87	CHANGED	pcL+pYYopsShEh+NloGht.pt...ps.phlphh.spphhplsLlGcDKcKa+c.ssc.pslDVFlVpEt.pchpuppYSlGGlTKoN	........cL+pYYopsShEhcNloGhh.p....tspphlphh.pp..phhpltLlGcDc.pKY+ctsp...slDVFhVpEt.pchpuphaSlGGlTKpN................	0	12	12	14
+9032	PF09200	Monellin		Monellin	Sammut SJ	anon	pdb_1mol	Domain	Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs against a coiled antiparallel beta-sheet [1].	23.60	23.60	23.60	87.80	21.90	23.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-7.73	0.72	-4.32	2	2	2009-01-15 18:05:59	2006-08-18 11:59:41	5	1	1	49	0	22	0	41.50	20	87.37	CHANGED	tEhchh-ht.a...oppLh+hslsE-.KhtththLpFNtsl.P	tEhchh-ht.a...oppLh+hslsE-.KhtththLpFNtsl.P	0	0	0	0
+9033	PF09201	SRX		SRX	Sammut SJ	anon	pdb_1nrj	Domain	Members of this family, which are predominantly found in eukaryotic signal recognition particle receptor alpha, consist of a central six-stranded anti-parallel beta-sheet sandwiched by helix alpha1 on one side and helices alpha2-alpha4 on the other. They interact with the small GTPase SR-beta, forming a complex that matches a class of small G protein-effector complexes, including Rap-Raf, Ras-PI3K(gamma), Ras-RalGDS, and Arl2-PDE(delta) [1].	25.00	25.00	26.20	141.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.91	0.71	-4.54	5	23	2009-01-15 18:05:59	2006-08-18 12:22:27	5	5	22	1	13	22	0	149.30	57	24.56	CHANGED	MFDQLAIFTPQGpVLYpYNsLsKKFSEsQlNuFIScLIopPVo+cc.......cshsSKLsoIs.o.pKsocSFoslFHloKQPELYFVlTYAE.pSLELNsEAEpVLsLuLpLWDSLsLN-uILcNhpG+ucKNcHNas-ILpulsE-IcKF-pYF	MFDQLAVFTPQGQVLYQYNCLGKKFSEhQINuFISpLITSPVT+KE.......cuh.casLLoIN.......S..p.....ccN........osSFsAhFalsKQPELYFVVTaAE.QTLELNQEspQTLsLsLKLWNSLcLsESIL+Nl.pGpsc.KNcHNYlDILpGl--DLcKF-QYF....	0	1	6	12
+9034	PF09202	Rio2_N		Rio2, N-terminal	Sammut SJ	anon	pdb_1tqi	Domain	Members of this family are found in Rio2, and are structurally homologous to the winged helix (wHTH) domain. They adopt a structure consisting of four alpha helices followed by two beta strands and a fifth alpha helix. The domain confers DNA binding properties to the protein, as per other winged helix domains [1].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.78	0.72	-3.91	29	449	2012-10-04 14:01:12	2006-08-18 13:09:27	6	7	407	5	321	479	8	80.70	43	19.50	CHANGED	h+aLop-DFRlLoAlEhGh+NHEhVPspLlsphupL+..tsusp+.tlpcLh+tcLls+...pstpY..-GY+LTYtGYDaLAL+sh.scR	..............hRaLsp-DFRV...LsAlEhG.h+NHEl..VPspLIsplusL+..puusp+.hlpcLsKhcLls+...cstpY................-..GY..RLTas...GYDaLAL+ohspR...................	0	105	187	266
+9035	PF09203	MspA		MspA	Sammut SJ	anon	pdb_1uun	Domain	MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel [1].	19.70	19.70	20.70	22.10	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.15	0.71	-4.83	19	280	2009-01-15 18:05:59	2006-08-18 13:29:33	6	2	59	10	90	299	3	172.20	25	80.36	CHANGED	PDGhp....lTVstpDEptsslPsLsss...hssRphhVuGshsus...........................lsGssst..ssGpLpsGY.lGCslslus.....hussuGhoPulsh..shss.s..s.uh.s.h...hsuuhsl....................sLtPGtlpsVslst.p-hcGsssa.................VthpshclplsGCsG.uhlRSYAslstpT-sssthlshYGtshsl	.......................................sGhp....lslp..ttsphhsslssL.sss....hoREhal..S.....Gpsssp.........................lsG..sust.....hsupLpsGY...plGCthslus................hss.ss.G.ss.suls.h...........shs.s......s..............................ss..s..l..ssulsl...................................................sltPGtltsls.l.p....hshpsssst........................lslssh+lplsGCuG.stlRuaApl...........pssTssspt.lshYGpPhsh...................................	0	10	60	76
+9036	PF09204	Colicin_immun	ColicinD;	Bacterial self-protective colicin-like immunity	Sammut SJ	anon	pdb_1v74	Domain	Colicin D, which is synthesised by various prokaryotes, adopts an antiparallel four helical bundle fold: the helices are tightly packed, forming a compact cylindrical molecule. The protein specifically cleaves the anticodon loop of all four tRNA-Arg isoacceptors, thereby inactivating prokaryotic protein synthesis and leading to cell death [1]. This family also contains immunity proteins to klebicins and microcins. Many bacteria produce proteins that destroy their competitors. Colicin D is one such. The immunity proteins are expressed on the same operon as their cognate bacteriocins and protect the expressing bacterium from the effects of its own bacteriocin [2].	21.60	21.60	23.60	23.20	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.88	0.72	-3.90	10	59	2009-11-02 17:58:57	2006-08-18 13:44:51	5	1	47	3	11	46	0	78.90	43	88.30	CHANGED	MS.hsll-LA+sFlpp+lSAppFoEsahphW+lERcsthhl+D.spslscCLuplFshADhYsPDs-.R--..YElD--pLRcEV+plLcKap	...................Ms.hhllchA+pFlstcloAp.Fuptahtha+hEpcpt.hhpD..spplspsLsslFshADhYsPDsD...RE-...YElDDcpLhcpVhpllsKhp.....	0	2	6	9
+9037	PF09205	DUF1955		Domain of unknown function (DUF1955)	Sammut SJ	anon	pdb_1vdu	Domain	Members of this family are found in hypothetical proteins synthesised by the Archaeal organism Sulfolobus. Their exact function has not, as yet, been determined.	23.70	23.70	23.70	188.30	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.00	0.71	-4.71	4	17	2009-01-15 18:05:59	2006-08-18 13:52:30	5	1	17	1	6	12	0	159.40	67	94.03	CHANGED	Ell+KLM-AK+hllDGhl-cGlcIlpchspSSshcEhNWhICNllDohsCchlhpsL-sIGphFDlotCtNLKpVlpChhhhNp.SEaVDhALDhLVtpsK+DpL-cIhp-lh..NpclssplLlKIAsAh+KlGspR-us-LLpcACc+GlKEACpslspl	.ELRRKLIEAKKLILDGFVEQGIELLSKTIoSENIKESNWIICNVIDTADCDAVVKTLDSIGKIFDhSPCANIKRlVYCYALlNKsSEYVDLALDlIVKuNKKDuLDKLYNDLK..NEKINPEFLLKIGhAYKKLGAV+ESNEVLRKACENGLKEACENIKEI..	0	1	1	5
+9038	PF09206	ArabFuran-catal		Alpha-L-arabinofuranosidase B, catalytic	Sammut SJ	anon	pdb_1wd3	Domain	Members of this family, which are present in fungal alpha-L-arabinofuranosidase B, adopt a beta-sandwich fold similar to that of Concanavalin A-like lectins/glucanase. The beta-sandwich fold consists of two anti-parallel beta-sheets with seven and and six strands, respectively. In addition, there are four helices outside of the beta-strands. The beta-sandwich strands are closely packed and curved with a jelly roll topology, creating a small catalytic pocket. The domain catalyses the hydrolysis of alpha-1,2-, alpha-1,3- and alpha-1,5-L-arabinofuranosidic bonds in L-arabinose-containing hemicelluloses such as arabinoxylan and L-arabinan [1].	25.00	25.00	26.10	25.70	24.50	23.20	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.19	0.70	-5.48	7	132	2009-01-15 18:05:59	2006-08-18 14:15:12	6	11	81	4	81	133	29	312.70	58	63.03	CHANGED	PCDlYuuusTPClAAHSTTRALYuuYoGPLYQVpRuSDGsTsDI.......uPLo.AG....GVANAuuQDsFCANTTClIoIIYDQ..................................Su+GNHLTpAPsG.uFsG...PsssGa........................DNLAsA.GAP.....VoLsGpKAYGVFloPGTGYRNN.sspGoAsGDpsEGhYAVLDGTHY..NuuCCFDYGNAETsStDTGs.......GHMEAIYF..GssTlWGp..GsGsGP..............WlMsDhENGLFSGsss...c.NuusPuIs.RFlTAllKGps....shWAIRGGsAuoGuLSTaYsGsRPssoGYsPMuK.......EGAIILGIGGDNS.GAQGTFYEGsMToG..aPSDATENtVQANlVAAtYusss	.........PCDIYuuGGTPCVAAHSTTRALYuuYsGsLYQV+RuSDuuTpsI..............usLo.A.G....GlAsAA.....AQDoFC..Au.TTClITlIYDQ..................................SG+GN+LTpAPsG..uh.pG.......Ps.s.sGh.......................................DsL.As....A.huAP.......VTl.sG.pKAYG.Val.uP..GsGY.RNN.ss.sGs..ATGDpsEGhYAV..hDG....THY....NuuCCFDYGNAETs....spDsGN.............................GpME.AIYF..Gsss..h.aGs.....GuGsGP..............WlMADLENGLF..S.G.sss......t.NsssP...olstR.FVTAhlKGps....spWAlRGGNApSGuLoTaYsGs.RP.t.........s...............GYsPMpK.......EGAIILGlGGD......NS.....suupGTFYEGVMToG..YPSDATENuVQANIVAAtYus.u...................................................................................	0	32	52	74
+9039	PF09207	Yeast-kill-tox		Yeast killer toxin	Sammut SJ	anon	pdb_1wkt	Domain	Members of this family, which are produced by Williopsis fungi, adopt a secondary structure consisting of eight strands in two beta sheets, in a Greek-key topology [1].	21.50	21.50	22.00	196.20	21.10	20.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.28	0.72	-3.55	2	2	2009-01-15 18:05:59	2006-08-18 14:27:41	6	1	2	1	0	4	0	86.50	88	69.48	CHANGED	DGYLlMCKNCDPNoGSCDWKQNWNTCVGIGuNVHWMVTGtS.sGpQGCAhIWEGSGCsGRSTTMCCPusTCCNINTGFYIRSYRRVE	DGYLlMCKNCDPNoGSCDWKQNWNTCVGIGuNVHWMVTGtS.sGpQGCAhIWEGSGCsGRSTTMCCPusTCCNINTGFYIRSYRRVE	0	0	0	0
+9040	PF09208	Endonuc-MspI		Restriction endonuclease MspI 	Sammut SJ	anon	pdb_1sa3	Domain	Members of this family of prokaryotic restriction endonucleases recognise the palindromic tetranucleotide sequence 5'-CCGG and cleave between the first and second nucleotides, leaving 2 base 5' overhangs. They fold into an alpha/beta architecture, with a five-stranded mixed beta-sheet sandwiched on both sides by alpha-helices [1].	25.60	25.60	26.00	82.40	25.00	25.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.58	0.70	-5.32	3	10	2012-10-11 20:44:45	2006-08-18 14:41:34	5	1	10	4	4	9	1	265.90	35	70.46	CHANGED	YTchLSDlLs......clsEKs..phtpGlpus+LGNcaE+aIV-lLNDlcNLutYNsNppAQpchc....cIhcclLccLsL-ctaDpILEVTuTs.DIs+LpNGGSPKTDlolRlphssKEh+IsNISIKNTpcK+VSIHEYsVcDlloslulSDoD.L+pLlc+FQcsGStKcFsulpsp+splL-ps..LcPYpE+lIcWsVT..up+stssLLc-KIQlsshIIsRNtsuVssK..DDYlKcYIEEhStAhGKG.FGTPFsWTYPSK+RGQKIQlKG	............hpp.Lo-lhs......pI.EKAspNlupGlRuslLGNshEppIVNlLNDlcNlshWNs.pssppshc...YcIaKcIlccl..slc.cth..-pIl-loAT...s.-IPhLp....NtGKPKTDVpVTIpsss..Kch.IhsISlKp..TpcppVoIHEhoVccllosLclS...-S.....D....LppALc+FQcVGStKKlhsppssptclL-cp..LcsYN+cLIcahls..u.hu.sslls-KIQhsshIIspsphsVhs+.....D-Yl+cYIpEhstt.uKGtFGTPFpWTYPSKKRGpKIQlKG.	0	1	4	4
+9041	PF09209	DUF1956		Domain of unknown function (DUF1956)	Sammut SJ	anon	pdb_1t33	Domain	Members of this family are found in various prokaryotic transcriptional regulator proteins. Their exact function has not, as yet, been identified.	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.24	0.71	-4.19	57	836	2012-10-03 00:15:22	2006-08-18 14:51:42	6	2	775	2	151	427	30	123.30	42	54.72	CHANGED	scppLpshlcshlth..lhsp....psthhs+hhhRE...hpP.osAhc..plhpphhtPhpphlsplluplhGts......ssstphthpshollGpslhatlu+pshhthhs...shsst.htplpslhpch..hphhLsul	..........................................h.R-hlltAh+sMlph...Lsp-....-T.lsl.....SK.FluREQ....L..SP..TuA.Yc..LlH-Q...VIsPLH...s+LsRLlAAaTGsD......A.sDo.ch.lLH.THALlGplLAFRLu..+ETILhRsGWs..saDc-cs-hIsp.sVssHl-llLpGL................................	0	40	90	121
+9042	PF09210	DUF1957		Domain of unknown function (DUF1957)	Sammut SJ	anon	pdb_1ufa	Domain	This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been defined.	25.00	25.00	28.40	27.10	22.80	19.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.27	0.72	-3.96	57	366	2009-09-10 21:40:42	2006-08-18 15:02:37	6	6	355	5	163	338	133	102.80	33	18.87	CHANGED	.clccAscpMlclssphs...t.sstlpp..RsLsQAARELLLAQSSDWuFIhpssTss-YAtcRhccHlpRFhcLhptlp....pspl........s....pphLpplEttDslFPpIsa+..ha	...........................h.pstpphhchspt...........ssthcc...RsLsQhsRElLLspSSDWsFllsssoss.......-YAppRs+pHhppFpclhpslt....suc.h........-.......pchL.p.t.hcp.tDslFs.slDhRha......................	0	67	120	148
+9043	PF09211	DUF1958		Domain of unknown function (DUF1958)	Sammut SJ	anon	pdb_1tvf	Domain	Members of this functionally uncharacterised family are found in prokaryotic penicillin-binding protein 4.	23.40	23.40	23.70	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.14	0.72	-3.90	9	328	2009-01-15 18:05:59	2006-08-18 15:22:48	5	2	303	6	15	172	0	65.70	53	15.00	CHANGED	YKKlLSKGppcIDGKKYplccDLYDVVPKspst...+lhlc-.GplplDhsRpalssphtss.pVpspc	....YhKlLSKGEQcIsGKKYhVcNDLYDVlPpchsp...aKlsVED.G+.V+sDYPRcFlNpchuPP.oVEspp.......	0	2	3	13
+9044	PF09212	CBM27		Carbohydrate binding module 27	Sammut SJ	anon	pdb_1oh4	Domain	Members of this family are carbohydrate binding modules that bind to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. They adopt a beta sandwich structure comprising 13 beta strands with a single, small alpha-helix and a single metal atom [1].	19.50	19.50	21.70	20.10	19.20	17.00	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.07	0.71	-4.24	2	51	2009-01-15 18:05:59	2006-08-18 15:57:36	5	14	33	6	9	53	0	171.90	24	23.72	CHANGED	hQ.s.A.El..pFShsp-hpNhassGTWQApFthPsIp...pststsLphNVsLPGpuDWEEV+V.lp.hspLs.sphlpaDlhlPcV-.lsGtLRPYhsLNPGWlKIGlD..psslsshphVohcsppY+hhHVplEFsthPsVNELalslVGs+LtYcGPIaIDNVpLaKK	...............................................t..........................................ht..t....t......sssuLclsls.hsss..s..s.W-Ehc.......l....h......p......th.....t.......c...l..sshptlca-.lalP..ps..p..t...h...s.Gslps.........h.us..l...s..s.GW.s.c....l....shsh.p.ph.s..lpshcp.l....pl..s.GppYtp..hpssh....p....h...s...p...s...t...p.hs...pL...hlplsGsphsY.sG..sIYlDNlcL...t...	2	5	7	9
+9045	PF09213	M3		M3	Sammut SJ	anon	pdb_1mkf	Domain	Members of this family of viral chemokine binding proteins adopt a structure consisting of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds. They bind with the CC-chemokine MCP-1, acting as cytokine decoy receptors [1].	25.00	25.00	104.10	104.00	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.24	0.70	-5.99	2	8	2009-01-15 18:05:59	2006-08-21 09:23:23	5	1	3	8	0	9	0	332.90	57	90.18	CHANGED	SsVshpohshsp.cpt--hpsa......CLh.sphpsT.Cus.hccl.p+shapL.shCNVKsphhVsa.shcchG..hhpuRLPhPohuusssscll+VLVlAEus....pP.ccaaA.lth.T...shtLoD.NshFpoca.plW.lsls+p.VDlshhhtuhhhtt..usplTlhhsYssTFTWCGpl.uls-.shP.PShpAhpsl...Chs.hRY.sup.Fpc.DGCptEoth.p.ohlhPh...Gs.spphphNTCsCahKYs.lp.Lsshc+lhlhslush.uhhpPlYVhssYFsSoc.Ns.t.us.L.aCsl.hppts.Ghapo..pus.pCPh+hs.Gpsp.VL.s+hs..sh.plVGlolhh-GQpaRlpYhG	SsVshpohshsp.cpt--hpsa......CLh.sphpsT.Cus.hccl.p+shapL.shCNVKsphhVsa.shcchG..hhpuRLPhPohuusssscll+VLVlAEus....pP.ccaaA.lth.T...shtLoDhNshFpoca.pIW.lsls+p.VDlshhhtuhhhtt..usplTlhhsYssTFTWCGpI.uls-.shP.PShpAhpsl...Chs.hRY.sup.Fpc.DGCptEosh.p.ohlhPh...Gs.spphphNTCsCahKYs.lp.LsAhc+lhlhslush.uhhpPlYVhssYFsSoc.Ns.tPusKLYHCALQMTSHD.GVWTS..TSSEQCPIRLVEGQScNVLQV+VAPTSMP+LVGVSLMLEGQQYRLEYFG	0	0	0	0
+9046	PF09214	Prd1-P2		Bacteriophage Prd1, adsorption protein P2	Sammut SJ	anon	pdb_1n7v	Domain	Members of this family form a set of bacteriophage adsorption proteins, composed mainly of beta-strands whose complicated topology forms an elongated seahorse-shaped molecule with a distinct head, containing a pseudo-beta propeller structure with approximate 6-fold symmetry, and tail. They are required for the attachment of the phage to the host conjugative DNA transfer complex. This is a poorly understood large transmembrane complex of unknown architecture, with at least 11 different proteins [1].	25.00	25.00	1204.10	1203.90	17.00	16.70	hmmbuild  -o /dev/null HMM SEED	560	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-13.00	0.70	-5.95	2	7	2009-01-15 18:05:59	2006-08-21 09:39:33	6	1	6	2	0	8	0	555.70	90	93.92	CHANGED	AshsVPKLG.FPshAVhDIDNVP.DSSsTGSRWLPSlYpGuNYauGGPQtLpAphusFDSssRLPYNPRT-sNPAGNCAFuFNPFGQYISNISSAQSVHcRIYGID.NsEPLFoPNAASITNGGNPTMSQDhsYHNIGPINoAYKAEIFRPVNPLPMSDTsPDPETLEPGQs.PlIKoDGlYosSGIAuFIFD+PVTEPNPNWPPLPPP.IPIIYPhPALGIGAAAAYGFGYQVThYhWEplPVEFIADPtTCPApPTTDKVIIRTTsLNPEGoPCAY-suIhLVRQsuNPMNAVAGRLVP.V.DIsVDIFLTGKFFsLsPPhRlTNNYFAD-pVpE.TVThGNapsshuusYatVYpTDGhGhApsFIu.GGuGlSALlpLQDsoVlD.LaYSlPLSlGGStushcEWlANNsGhaPhShGhsKosLlEIPRRpLEAIpPQssPG..DlFhLD-SuuYASFSSFIGYspuAYYVAGAuTFMDVENPDpIIFlLRsGtGWYuC-IuDALhI.....uDsEaDSVDYFAapGGVMFIGSARYTEGGDPLPIKYRAlIPuLP	ANFNVPKLGVFPVAAVFDIDNVPEDSSATGSRWLPSIYQGGNYWGGGPQALRApVSNFDSsNRLPYNPRT-sNPAGNCAFAFNPFGQYISNISSAQSVHRRIYGIDPNDEPLFTPNAASITNGGNPTMSQDTGYHNIGPINTAYKAEIFRPVNPLPMSDTAPDPETLEPGQs.PLIKSDGIYSsSGIAuFIFD+PVTEPNPNWPPLPPP.IPIIYPTPALGIGAAAAYGFGYQVTVY+WEEIPVEFIADP-TCPAQPTTDKVIIRTTDLNPEGSPCAYEAGIILVRQTSNPMNAVAGRLVPYV.DIAVDIFLTGKFFTLNPPLRITNNYFADDEVKENTVTIGNYTTTLSSAYYAVaKTDGYGGATCFIASGGAGISALVQLQDNSVLDVLYYSLPLSLGGSKAAIDEWVANNCGLFPMSGGLDKTTLLEIPRRQLEAIsPQDGPGQDDLFILDDSGAYASFSSFIGaPESAYYVAGAATFMDVENPDEIIFILRNGAGWYACEIGDALKI.....ADDEFDSVDYFAYRGGVMFIGSARYTEGGDPLPIKYRAIIPALP	0	0	0	0
+9047	PF09215	Phage-Gp8		Bacteriophage T4, Gp8	Sammut SJ	anon	pdb_1n7z	Domain	Members of this family of viral baseplate structural proteins adopt a structure consisting of a three-layer beta-sandwich with two finger-like loops containing an alpha-helix at the opposite sides of the sandwich. The two peripheral, five-stranded, antiparallel beta-sheets are stacked against the middle, four-stranded, antiparallel beta-sheet. Attachment of this family of proteins to the baseplate during assembly creates a binding site for subsequent attachment of Gp6 [1].	25.00	25.00	86.40	25.90	19.70	24.30	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.86	0.70	-5.28	10	76	2009-01-15 18:05:59	2006-08-21 09:49:36	5	2	62	12	0	68	1391	281.80	34	83.52	CHANGED	uIVT...sKFRTcshhNFYcolG...............Dsss+sTIYhoFGRscsWucNEs-stFAPPYPsDShcGlsDsWocMlGslKIspShLcsVVPR+DW...............................GDoshssPppFaluDIVVVNStPhNpT-.u.uGWMVYRClDlP-s........GtCSIsolssKsEClplGGcWTss.....tcSltsPpGpusu...I-sG.DGYlWEYLYTIPPDssINcCTNEaIVVPaP-ELhtDPsRWGY-ssls...........W.ssch-llYRhKssTlRF+AahDSlhFspsuhsGNpGFRQlSlIlNPL.hKucPsss-VKAsts.tYsspplphcSGpMI.........YMENRpPIh+ohDQTEElsIlFsF	.....................................ullT...spFRh.phhpFhps.lt...............ss.spsplYhhhGRspsWsspp...........uPP...PsDshpthtshaspMhuhh+l.tS.httVl.RhDW.........................ucsthss...shphh.s-hhVsN...........usa.VY+Cl.ssss........s............s...Gt..Tsp.....hpS...sth.........lss...G.DGYhWcYlYpIPsssslphhoN-ahsV..........sphuhcssls...........a.pschchlah.p..ssoh.p......puhhDul...hspsuhsGstG..plSllssP..tpupsssssVcus...ts...sYshsclphcSGphl.........Yh-NRpsIhpuhDQsE-lpIlhpF....................................	0	0	0	0
+9048	PF09216	Pfg27		Pfg27	Sammut SJ	anon	pdb_1n81	Domain	Members of this family are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding [1].	25.00	25.00	119.70	118.90	22.30	19.90	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.29	0.71	-4.69	2	7	2009-01-15 18:05:59	2006-08-21 10:00:20	5	1	5	1	4	8	0	176.60	49	44.52	CHANGED	Y+YEc..cpctsL.shIppls-lEFpusss..YLhhhlspD..KaN.uLpDp.uIh+.lpKsQNch..hhl..clpsshs.RIS-RLhsashDK-lTt.YlKKlcDhhhlEpcshcph.h.Vcpt+php-KKRlhNshc.I+hha-o...hp.lphscDph.sAhhRlSphlsDl........I.hLP	.............................hI.plhplEFcssps..YLhhhls..pD.EKaN.uLcD+luIh+.lpKNQN+as.Fhl..clpDshs.RISDRLhsYChDK-lTEsYlKKlcDhhhlEpcVhEpl.h.V-Ht+ph+EKKRlhNDhcLI+hha-oh.hspslphTDDQacsAAhRlSpFl.Dl........I..........	0	2	2	3
+9049	PF09217	EcoRII-N		Restriction endonuclease EcoRII, N-terminal	Sammut SJ	anon	pdb_1na6	Domain	The N-terminal effector-binding domain of the Restriction Endonuclease EcoRII has a DNA recognition fold, allowing for binding to 5'-CCWGG sequences. It assumes a structure composed of an eight-stranded beta-sheet with the strands in the order of b2, b5, b4, b3, b7, b6, b1 and b8. They are mostly antiparallel to each other except that b3 is parallel to b7. Alternatively, it may also be viewed as consisting of two mini beta-sheets of four antiparallel beta-strands, sheet I from beta-strands b2, b5, b4, b3 and sheet II from strands b7, b6, b1, b8, folded into an open mixed beta-barrel with a novel topology. Sheet I has a simple Greek key motif while sheet II does not [1].	25.00	25.00	34.10	33.60	24.40	23.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.92	0.71	-4.65	6	84	2012-10-02 12:51:43	2006-08-21 10:21:06	5	3	73	3	10	59	2	147.10	46	39.22	CHANGED	chuscsahhahKRLoANDTGATGuHQuGhYIPpshsppLFPslN+s+-pNPolhlss+hpSHpssDSphRAIYYNs+hhs...tTRNEtRITpaGtuts.hhs.csTGALsllAF...ctstcsthscsWVCsos-EtDllEutlGpllPGu....lhss.uupI	..........sspshhlYlKRLSANDTGATGGHQsGlYIPpsh.s-c..LFPslsc..s+phN..Polhlps+hsoc.sss-.SphRhlYYNs+has...tTRNEtRITRaG+s.s.l.ss-NTGuLhlLA.....cts.....tcsp.hphaVhsos-E.Dlh.sthGpllPGs....Lh.s.ttpl..................................	0	4	6	8
+9050	PF09218	DUF1959		Domain of unknown function (DUF1959)	Sammut SJ	anon	pdb_1nxh	Domain	This domain is found in a set of uncharacterised Archaeal hypothetical proteins. Its function has not, as yet, been described.	21.10	21.10	21.70	21.40	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.54	0.71	-4.31	5	29	2009-09-10 17:31:46	2006-08-21 10:27:44	5	1	29	2	19	28	0	115.10	42	84.75	CHANGED	KhNlIKuNRalMEDVIlPISKALKlslEEVIDIFscKLDhuSLYELHAYsEQA+MGCLGRKVDIDLGLCWlsDFFGLISK-DADLIRKKVVE-hIlcKKPYKEALEEGR+hllcLLK	............KhplIcs.Ra.hE-lllPlSKtLplsh-Elh-lFhcphDhuoL.plHAhhEpA+hsCLsc+lDhD.LuLCWlsDahsLIS+c-ADhIRcKVscphllpp+sYc-AL-EGRphllclLK.....................	0	4	9	15
+9052	PF09220	LA-virus_coat		L-A virus, major coat protein	Sammut SJ	anon	pdb_1m1c	Domain	Members of this family form the major coat protein of the Saccharomyces cerevisiae L-A virus [1].	25.00	25.00	27.00	25.30	23.30	21.20	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.35	0.70	-6.03	2	18	2009-12-01 14:28:50	2006-08-21 10:41:59	5	2	13	2	5	23	0	311.60	31	49.63	CHANGED	ML+FVsp.spctpssLap.ppscGThsshsRlRsDFKaDsLsFsRshssSQcaThVGpshsshsEspS.L-GlsKKYLTLDGuluhDNVhpEL+sosGh.uNhlAuHAYNlsuWRWYDNHVALLhNhLRhYhLpsLsEpuphSsGchPhYcDGHVhIcLssTl..pstsspasWPucRus-SYP.Ws.hoE.hPshDsPalDlRPLT.pEsphVLMMhucW+.pTNhtlDa.sPpLA-KhhYRat.slpshsEWl-u-tTsspah.PpS+VhhSALRKYVsHNpLYNQFYTAspllAQlMhpshPssAEGhsWLhHss.VplPKFGSlRGRYPFL.SG-AAhIQApALEDWuAlhAKPELlFTYuM.lussLNhGLhlRcsKtohhhsp.csSa-DshFLpPETFhtuAluhsTG.DAPLNGMuDVYVhYP-Llph	.................................................php..hps...p+.h........p.hs.lG...s.hsps.s.L-Gltt.hhs.cGslshs.l..tLpp.shh.ts..s.p.ht.tth.ahcNhsuLLhNhLRhYhlt.ltp.tth.pssph.hYcsGHspl..s.tl...sts.pht...WP.....spt.ptths.hs.h....P...ssshl.hpshs.pcsthlL..hhupat..sshtlsa..PpLspphhhph...ht..s...........h..h..psthhhsAl+cYVstNplYspF.sAhtlluQlhhoshPssAEuhsWLhp.s.VslPpFuSlRGhYPhL.pG-uhhhptpAl--WsthhspP.phlFohu..Mhhuss...lphGLhhRpsphp.hhst...th-p.hhlpscohhtuhhuhsoG.phs..t.tshhh.........................	0	0	1	5
+9053	PF09221	Bacteriocin_IId	Bacterioc_AS-48;	Bacteriocin class IId cyclical uberolysin-like	Sammut SJ, Coggill P, Eberhardt R	anon	pdb_1o82	Domain	Members of this family are membrane-interacting peptides, produced by Firmicutes that display a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. They adopt a helical structure, with four or five alpha helices forming a Saposin-like fold [2,5].  The structure has been found to be cyclical [1, 3, 5]. It should be pointed out that one reference [4] implies that both circularin A and gassericin A are class V or IIc-type bacteriocins; however we find that these two proteins fall into different Pfam families families, this one and BacteriocIIc_cy, Pfam:PF12173.	23.00	23.00	23.30	23.00	22.00	21.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.14	0.72	-4.06	17	111	2009-09-11 17:00:14	2006-08-21 10:51:36	5	1	108	12	12	62	0	63.50	51	69.18	CHANGED	AutlGIususAtplVsllssuuolsolIulluulsuuGshu.......sulhAslKphlp+pGpttAssW	.......AGTLGISTtAAsTVVNlIsAhSTVsulISIV.GAlTGsGuIu.......uGIsATVhhllKKpGtAtAAhW.......	0	5	8	9
+9054	PF09222	Fim-adh_lectin		Fimbrial adhesin F17-AG, lectin domain	Sammut SJ	anon	pdb_1o9w	Domain	Members of this family are carbohydrate-specific lectin domains found in bacterial fimbrial adhesins. They adopt a compact, elongated structure consisting of a beta-sandwich with two major sheets: one consisting of five long strands in mixed orientations, and a front sheet with four antiparallel strands, forming an immunoglobin-like fold [1].	25.00	25.00	25.40	25.10	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.22	0.71	-4.97	2	22	2009-01-15 18:05:59	2006-08-21 11:05:39	5	1	9	15	0	29	0	167.20	50	47.14	CHANGED	VSFIGSTENDVGPS.GSYSpTHAMDNLPFVYNTG.NIGYQNANVWRIStGFCVGLDGKVDLPVVGSLDGQSIYGLTEEVGLLIWMGDTNYSRGTAMSGNSWENVFSGWCVG.NhsSTQGLSV+VpPVILKRNSSApYSVQKTSIGSIRMRPYNGSSAGSVQTTVNFSLNPF	................................................................PS..uYSpsauhDNLPFha.N.sGhsI.......tYQsuNs.....a+h.....osG......FCssL-uKsDLPVlGoLDGQSIYsLT-E..lGlLIahGDTNYSRsoAhsGNSWpsVFSG.WCsu...hSoQGhSV+VhPVlLKps.uu.upYoV.+TpIGSIRhR.hssSphGph................................	0	0	0	0
+9055	PF09223	YodA		YodA lipocalin-like domain	Sammut SJ, Bateman A	anon	pdb_1oej	Domain	Members of this family of prokaryotic domains have been identified as part of the response of bacteria to a challenge with the toxic heavy metal cadmium. They are able to bind to cadmium, and ensure its subsequent elimination [1].	20.50	20.50	20.60	20.90	19.80	19.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.17	0.71	-4.63	33	1239	2012-10-03 08:47:39	2006-08-21 11:21:21	6	5	1174	5	75	565	3	177.80	56	49.23	CHANGED	-pccplhpGYF-DspVKDRsLSDWpGcWQSVYPYLpcGTLDtVhsaKAccsc.chTApEYKsYYcpGYpTDV-pIsI..cssslTFhp.sspspospYpYsGacILTYcpGNRGVRalFcts-usu.st..P+YlQFSDHsIuPpKusHaHlYaGs-ppt.LLcEl-NWPTYYPupLouc-IscEMlAH	...................................-.s-ppstsGhF-DssVcD..RsLSDasGsWQSVYPaLpsGpLD.....VFchKAct.s.t..chThtEhKsYYcK.GYpT.DlppIsI..c.c.s..p.lEFhp.....s......s....p.....s....p..o.s.p.Y.cY.sG....hK.IL...TYppGp+.GV....R....a....L....FEs...p.Ds..s.u..tt..KY.lQF......SD.H.IA.P.p.K.u.pHFHIFhGs-SQpuLL...p.EM-N...W.PTYY.P.pLoupElspEMluH............................	1	20	36	56
+9056	PF09224	DUF1961		Domain of unknown function (DUF1961)	Sammut SJ	anon	pdb_1oq1	Domain	Members of this family are found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been determined.	25.00	25.00	28.80	25.80	19.50	16.40	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.61	0.70	-5.25	3	41	2009-01-15 18:05:59	2006-08-21 11:26:34	6	1	38	4	21	39	9	214.70	46	84.29	CHANGED	REG.uLLYpNPLuSPcDV+GWVMEGsGpluFcDGuLHLSs.hDsEclGD-AHFVFWCPETFPDGIlVoWDFhPlcEPGLCMlFFAAAGhsGEDLFDucLAcRTGpYPQYHSGDINALHLSYFRHKHA-ERAFRTCNLRKSRGFHLVApGADPLPPs-DAcsPYRMKLIKDGuYV+FSINGLPILEWTDDGcRaGPVLGuGKIGFRQMAPL+AAYRNFsV	......................................................thlYpNsLpSspDVtsWhhEG.su.ploh...sssthcLp..h...phsppu+FVaWCPEsFPDsI..hloW-FpPlc-..PGLsMLFFuA.AGhs..Gc.DlF.DsuLt.....RTGpYPpY..HSGDINsLHlSYFRR+as-ER.AF+TCNLRKStGF.HLVApGADPl.PsssD........Ap.u......sYRh.cllKDtstV+FuI.N......sLPlhpWpDDG.ss.hGPVLspG+IGFRQMAPhtAsY+sLpV....	0	9	15	20
+9057	PF09225	Endonuc-PvuII		Restriction endonuclease PvuII	Sammut SJ	anon	pdb_3pvi	Domain	Members of this family are predominantly found in prokaryotic restriction endonuclease PvuII. They recognise the double-stranded DNA sequence 5'-CAGCTG-3' and cleave after G-3, resulting in specific double-stranded fragments with terminal 5'-phosphates [1].	25.00	25.00	118.70	118.40	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.89	0.71	-4.53	3	14	2012-10-11 20:44:45	2006-08-21 11:42:23	5	2	14	21	3	19	2	144.30	63	82.21	CHANGED	HsDhsKLlcLWPpIcEYQcLAsKHGINDIFQDNGGKLLQVLLILGLTVLPGREGNDAVDssGsEYELKSVNlELTKuFSTHHHMNPsIIAKYRQVPWlFAIY+NIsIcuIYRLcPDDLEsFYDKWERKWY-DGGKDINNPKIPVKYVMEYGclIW	.......DhttL.tLaPplpcaQtLAp+aGINDIFQDNGGKLLQVLLlhuLp.llPGREGNDAVDssGsEaELKSVNl-LT.KSFSTHHHMNPsIIuKYRQVsWlFAlYpsIslpplYhLpPc-LEsFYsKWEcpWapcsGKDINNPKIPlKYVhEaGplla...	0	0	2	2
+9058	PF09226	Endonuc-HincII		Restriction endonuclease HincII	Sammut SJ	anon	pdb_1xhv	Domain	Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence 5'-GTYRAC-3' and cleave after Y-3. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates [1].	19.30	19.30	20.10	312.90	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.84	0.70	-5.03	2	10	2012-10-11 20:44:45	2006-08-21 11:55:36	6	1	9	49	3	12	3	256.50	73	99.34	CHANGED	SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKpPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKpRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVD.ELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL	........SFhKsIYp-INspLlGppVP+Pp...SGTLSGHAAGEPFEKLVYpFLK+pLsDhTFKQYEYLNDLahKNPslIGHEARhKLFNSPTLLFLLSRGKsATcKWSIEN.FEEKQNDTADILLVKDpFYELLDVKTRNISKSAQuPNIISAYKLAQTCAKMIDNcEaDLFDINYLElDW.ELss--.LlChSTaFAELFKSpPS-LYINWAAAMQIQFHVRDLDQtFsGTREEWA+uYLKHFVsQAcpRAssMIsKFVKPFcKYIl.	0	1	3	3
+9059	PF09227	DUF1962		Domain of unknown function (DUF1962)	Sammut SJ	anon	pdb_1uoy	Domain	Members of this family of fungal domains are functionally uncharacterised [1].	21.30	21.30	21.80	118.50	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.42	0.72	-3.93	3	8	2009-01-15 18:05:59	2006-08-21 12:10:45	5	1	7	1	4	7	0	65.20	70	72.20	CHANGED	DTCGSGYGGDQRRTN......SPCQuuNGDRHFCGCDRTGVVECRGGKWTEIQDCGSSTCHGTNDGGAsC	DTCGuGYGGDQRRTN......SPCQAuNGDRHFCGCDRTGVVECRGGKWTEIQDCtuSTCHGTNDGGApC	0	0	1	4
+9060	PF09228	Prok-TraM		Prokaryotic Transcriptional repressor TraM	Sammut SJ	anon	pdb_1us6	Domain	Members of this family of transcriptional repressors adopt a T-shaped structure, with a core composed of two antiparallel alpha-helices. These proteins can be divided into two parts, a 'globular head' and an 'elongated tail', and they negatively regulate conjugation and the expression of tra genes by antagonising traR/AAI-dependent activation [1].	21.40	21.40	22.00	22.60	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.17	0.72	-3.87	14	32	2009-09-10 15:54:28	2006-08-21 13:14:02	5	1	24	12	10	38	1	100.10	36	95.07	CHANGED	Mphtsospss......sEtcshtuhhsuhpcu-LEsLsluAIR-HR+Llsts-slap-h..ussDspsusushpshptEYlptphcpcAQQptLosll-hLGalPcV	................Mp..sus.ss.....tsEh+shhuhhpulspu-LEsLolsAIRpHRpLltpA-pla.pt...hs-c.psupushts.phcYlctphchcAQ.ptlssllshLGalPcV...........	0	1	4	7
+9061	PF09229	Aha1_N		Activator of Hsp90 ATPase, N-terminal	Sammut SJ	anon	pdb_1usu	Domain	Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity [1].	22.50	22.50	23.00	23.00	21.30	20.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.58	0.71	-4.34	69	522	2009-01-15 18:05:59	2006-08-21 13:38:25	6	16	302	7	363	496	9	134.10	25	44.42	CHANGED	-KsstsWu+phlcphlss.....lp..h.psssh............................php...lsclsp..lcG.-usVspRK.GKlIsha-hclphpapGp....................tspst................hpGplplP-lup-.s..-t--hph.pl............shp.scssptp.....hcsll+pphhsp..l+ptltpahpcLhtp...up	.................................................-KssssWu+phlcp.h.Lhs.......lp.....s..p.ssss............................................psclsc..lpp.l-G.-us.lspRK.G..KlIhha-.hp.lpLpapGp......................................................................spss................hpGplplPpluc-.s...c.--h...ph...pl...................................sht...ps.p..s.ptp.........lcshh.+.pp...h..h...sp...l+ptltpahptLhtpa....................................................................	0	116	202	295
+9062	PF09230	DFF40		DNA fragmentation factor 40 kDa	Sammut SJ	anon	pdb_1v0d	Domain	Members of this family of eukaryotic apoptotic proteins induce DNA fragmentation and chromatin condensation during apoptosis [1].	25.00	25.00	52.10	36.10	23.10	23.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.69	0.70	-4.99	9	108	2009-01-15 18:05:59	2006-08-21 14:03:21	5	3	71	1	54	108	0	223.70	45	71.91	CHANGED	tllptAcpLloD-cuPcpp+lLushlpslp-phptEsR--DscWFEGl.-spF+oKpshM+hsspSRIRGYhpcscshhops....tsspA+c.hpchL-thpppLpuscY.ushFDRu.tctt.......................................................RLCTs-GWFoCQGsFDps..sCsttHoINPYusREuRILFSTWNLDHhIEK+RoVlPulscAlcc.h...............cG+clshtYFYpLLFThpNLKLVHIsCHcKssHcLp......CDps+hY+	..........h...pthcphls-.pt.ppp+lLssh.........ppphthpp+sEcspWFcGh..EpR.F+oKpthhphpspoRlRuYhhcspp.hops.......sscA+p.h.pllpthp.hLpuscY.u.aFDRs.tptt.......................................................................................spLCospG.FpCQGsasts..sC.....p..p..HoINPYusREshILFpTWNL.DHhIEhpRTllPsLst.slcc.................pst-lsh..aa..LFThcNLKLVHIsCHcKspHp.t......Cs.pc.Yp.........	0	11	15	32
+9063	PF09231	RDV-p3		Rice dwarf virus p3	Sammut SJ	anon	pdb_1uf2	Domain	Members of this family are core structural proteins found in the double-stranded RNA virus Phytoreovirus. They are large proteins without apparent domain division, with a number of all-alpha regions and one all beta domain near the C-terminal end [1].	25.00	25.00	1167.80	1167.60	18.80	18.40	hmmbuild  -o /dev/null HMM SEED	965	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.57	0.70	-7.14	2	12	2009-09-10 17:20:48	2006-08-21 14:21:20	5	1	4	2	0	14	0	964.70	62	94.51	CHANGED	pSVVSRsPlPlShhslS-lpKLFDI.sIppGSohpIV-cPQsoFhlphtcshascahCl-H.sAaEPuLhhHRl+hlaShLscYsuphISEVPh.sshlsph.VpslshsKhsDRNMsshAE+L.h-.-VhsApp-.hh.Y.RpSsstsPlTFtDDL..sVRERssLY+RY.VPap.lELuLashA.phLslQYCHPhlVYpYLpsRAPsFLhlsDQluLchhSAG.GpLhPRPVhplLDYsLVY.SPLALNNLuShLhp+Iphplhhp.lstVppsLuElVssSSsVoNsASuslspMNVtGVpTlAsFIhpShLNPNISYuhlutLsLDsFssFIYGsCLhLhQAlhPPSAlsAhpRlcINNthAYFLl+hhssQsshspll.NplI.slssh.pWpSscRDlLsAIYsNLhsu-hhl.NLlppYaRtsssppsspl.lPAcpTSYGhNETRulShPYLFGssIs.htPDsRLssYKpcLsLPsRSPILIsss.tpNslslp.lphKhshIhshY..NsFVppPstWlRNusSNoALLu+FhDsssNlhGIhEslLuNsYuNAVNsYCDSVYRAslPhpWKh+.slDPpDhhFslFGlsPpY.lhs-ulPDFFAGuEDILILQLlRAla-shSN+hGpsPschF+h--V.KslpEhVSlllppKlDsp+YFT-sMRSsoFSK.tW-pFltR.VupcLPsL.psIhsQs-pl.NYMsQhhtIhPIsDpFYlV+NSGhssRGSssPlhAuool..N.lpsshhItDapthstLhhppcpVD.so.ps.hps.F.tLppIuSsEFVRSs...pucshFT-..l-AI+VNMhs+a-LphhpEpGtaSKPsplpKlMapDhhSFlcSphuchhPPlhTlPIsIhLNsLGEssSsphRMRS.tlDEYFpsasGAQlllPlshVshchhsphp-LpshFsGsVslp.cPa.lh-shcssYl.hGsHtVhlDP	..SsVSRVPLPVSFluhpDVc+lFcIIPl+hGSTohIlDpPpVsFllhYs-sIYDDFMpIcplsAFEPSlTMHRVcslFSlhpKYCsSMlstVPThSohVu-lPVKuVTMScFGDRsMDpLApaLspEhElluAQtpNRthYVRouA.-VPhsFGDDLssAshERtN.YHpYpVPFHslELALYpLAs-LLchQYCHPTVshcaLpcRAPPFLsV-DpVu.+MhpAGsGsLMPRPVMELLDYoLVYpSPLALspLAoRL.SKISl+L+MRMVTEVQpolS-hluVSSosSs.uoSuItshNlhGVEsLslahARSlLNPNhuYA.IScLTh.AFpDFlYGoCLLLlQAhlPPSAIhApsRlhINNRLAYFLIRYIAh.ATYsRLssNpVlPphhNpDcWQ.sshDhLVAIYoNLLsGEtRLsplIphYFRGpsP.tVstIsIPAsQTuYtIsEppuISAPYLFGAPINtMAPDsRL.-aKpsLNLPPRSPIL.TNlEGsNVISLpNLhsKsDlIpAlY.LsGFs+.oPuhWIRNAu.NTAhLoKhlssVSNLouIYEAVLANTYANAlNVYCDo.Y+s-IPLNWKl.hoIcPKDhLFuVFGllPhYQL.sEAVPDFFAGSEDILILQLIpAVYchLup+LGssPTpaFHLEEVhpslScIVSILsppplDV+hYFTDS.+ShTFsKPhWDRFIRRs.ttpLPPLYclIhpQlssVYshhptMpcllPIsDaFYIsRNsGaVARGSopsIlAATSlYpNQhsVpppIssFo-AssLRLptRRVDNsShTosL-DMFYsLSSISSsEFVRSstRGcop.+hss..VssIKVNMRARYsLpIhTE-Gsh.+.PclKKhMaSDFlsFLhpHpp-P+sPllpIPITIGLNNlGtTTSTslR.cScsVDEYFKuYlGAQVlIPhDslslEplGSFsELRNhhossVVsRDKsW-IWssV-AoYVPIGNHsVpLDP	1	0	0	0
+9064	PF09232	Caenor_Her-1		Caenorhabditis elegans Her-1	Sammut SJ	anon	pdb_1szh	Domain	Her-1 adopts an all-helical structure with two subdomains: residues 19-80 comprise a left-handed three-helix bundle with an overhand connection between the second and third helices, whilst residues 81-164 comprise a left-handed anti-parallel four-helix bundle in which the first helix consists of four consecutive turns of 3-10-helix. Fourteen Cys are conserved in all known HER-1 sequences and form seven disulfide bonds. The protein dictates male development in Caenorhabditis elegans, probably by playing a direct role in cell signaling during C. elegans sex determination. It also inhibits the function of tra-2a [1].	19.80	19.80	45.60	45.40	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.05	0.71	-4.10	2	15	2009-01-15 18:05:59	2006-08-21 14:35:42	5	1	8	2	13	10	2	114.70	37	68.76	CHANGED	CCo.phhECCh-.lpFupPl+Cs.thcLth.h.Vh.ChQpELau.E.p.hhNLsDoVCCsVFupD.ND.pchC.o.ChTsMQ.PuLcsspKLp+IK-Cp.ppNsLYpCFs+C..hh+pchc.EshcFpp.Cs	.CCstpthcCCh-uIcFsh.lpCs.thphtt..hpshpClQpELauccs....hhslschsCCsVFtsD.sDspthChptChpsMpuPSlcussKLppI+pCp...hsNsLapCFppCpthhc.pt.c.Eshphpp.Cs.................	0	8	9	13
+9065	PF09233	Endonuc-EcoRV		Restriction endonuclease EcoRV	Sammut SJ	anon	pdb_1sx5	Domain	Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence 5'-GATATC-3' and cleave after T-3. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates [1].	25.00	25.00	35.50	34.70	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.62	0.70	-5.02	3	40	2012-10-11 20:44:45	2006-08-21 14:45:55	6	1	39	61	7	49	8	236.60	41	89.70	CHANGED	SsLlscIpDsNppWcVKGFIDu-s+IYoLSsDTKVISKILEIalFPhIpcFAccHcFpVlLPKcQNaYPDlSFlc.K-SscKIAIDIKTTYRNccNsK..sGFTLGuaTuYFRNRpSsKNIsFPYc-YluHalLGlVYTRVssRlDELKpYsIsELs+I.SVIKslclFLQEKYKIAoDpuGSGNTsNIGSI+.+h-Dll-GKGIFuchGE-lFDDYWhNYpphsh.psSQL+scsYsNISEY..apYR.G+	..........ht....t.lssptscWpl+GFIDhpKsIYTIouDTKllSKIlElhlFPt.lppFAccpGaclhhsppQNaYPDloFhs.....pssshKaAlDIKTTYR...pscs.s.....sGFTLGSasuYFRNRpusKNIpaPYscY.uHasLGllYoRs.s.p.p.h.-.Ep.chhsl-cLcpIsSVl+shpFFlpEKWKIASD+sGSGNTsNIGSIp..pIccllpGpGhFssL....GE-..lFD-YWh.N.a.shh.h...ptphphp.hssLtpa..hta....h.............	0	1	5	6
+9066	PF09234	DUF1963		Domain of unknown function (DUF1963)	Sammut SJ	anon	pdb_1pv5	Domain	This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	21.80	21.80	21.80	22.30	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.82	0.70	-4.11	34	835	2009-01-15 18:05:59	2006-08-21 15:34:19	5	12	604	1	134	636	11	217.00	27	78.00	CHANGED	SKhGGp.PalPps...paPp..............s.ppG.........p.PhhhLAQlNhs-ls.....p.lpsa..P.pp...GlLpFFls..p..........psppps..shcVhah-phtppp.....ppl.p-hshhp.h.........h.tthpl...p.p..........sl..pshphpp.ht..h.p...........cpppchhcchh-.h...........tps...p+..lGGYP.asQ............................ps.+pttc...........................pphhLLhQ..lDo-......tphshhaGDs.Ghh.FaIpcpDLtshcFsplhhsasC	......................................................................................................SKhGGh.PhLPtt...hcaPh......................................................................s..pps......................PhhhlAQl.Nhs.-ls..............t...p.a......P...pp.......GlLp.Falstps.................p...s.spt....shRll...Yhpp.hpph.h..........ppl.schp.hstt...........................httthplth..p.t.......................psl...p.s.hchpp.h.......ch.......................tt.pphhpt.l.hpph..................pt...hpp......lGGYPhasQ..............................................................-scp.pp..........................ttt.h...l.LhQ....lDSs.............sshshhWGDh...G.hstah.IpppDLtshcFsphhhshp..............................................................................................................................................	1	52	91	117
+9067	PF09235	Ste50p-SAM		Ste50p, sterile alpha motif	Sammut SJ	anon	pdb_1uqv	Domain	The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerisation and heterodimerisation (and in some cases oligomerisation) of the protein [1].	20.90	20.90	20.90	21.10	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.55	0.72	-3.95	3	28	2012-10-02 20:42:54	2006-08-21 16:06:02	5	2	27	2	16	31	2	73.20	54	22.58	CHANGED	-sFscWSTDEVlpWCtosLGl-EsDPLhpR.IRENcIsGSlLsELTLQDCKELCDsDLscAIKLKlhINKhlDScL	.........-DFopWSVDDVloWClSoLEl-E.s..DP.LCp+....LRENDIsGDLLPELsLpDCp-LCD.uDLs+AIKFKILINKhpDoc.................	0	1	6	13
+9068	PF09236	AHSP		Alpha-haemoglobin stabilising protein	Sammut SJ	anon	pdb_1w09	Domain	Alpha-haemoglobin stabilising protein (AHSP) acts a molecular chaperone for free alpha-haemoglobin, preventing the harmful aggregation of alpha-haemoglobin during normal erythroid cell development: it specifically protects free alpha-haemoglobin from precipitation. AHSP adopts a helical secondary structure consisting of an elongated antiparallel three alpha-helix bundle [1].	20.50	20.50	21.10	20.70	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.94	0.72	-3.78	3	32	2009-01-15 18:05:59	2006-08-21 16:22:21	5	1	27	10	16	34	0	85.80	62	82.00	CHANGED	QoNKDLISsGIKEFNVLLNQQVFsDPLISEEDMVTVVcDWVNFYINYYKKQVoGEQ-EQDKALQEFRQELNTLuusFLAKYRsFLKS+E	................puNKDLISsGhKEF....slLLNQ.........QVFsDPl.lSEEcMVTVVcDWhNFYINYY+pploGEpQEpD+ALQELpQ..ELNTLusPFLsKYRsFLKSp....	0	1	1	3
+9069	PF09237	GAGA		GAGA factor	Sammut SJ	anon	pdb_1yuj	Domain	Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].	20.20	20.20	20.20	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.75	0.72	-4.37	3	58	2012-10-03 11:22:52	2006-08-21 16:35:59	6	13	44	2	38	74	1	48.30	47	10.02	CHANGED	stsshhc+hsGllKIKSKSQSEQPATCPICQAVIRQSRNLRRHLELRHFKKPGV	...........................................+s+upS.-pPuTCPlCtAllRQSRNLRRH....LElpHh....................	0	7	11	31
+9070	PF09238	IL4Ra_N		Interleukin-4 receptor alpha chain, N-terminal	Sammut SJ	anon	pdb_1iar	Domain	Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response [1].	22.90	22.90	23.70	26.10	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.32	0.72	-3.88	7	71	2009-01-15 18:05:59	2006-08-22 09:17:01	5	2	37	4	27	64	0	90.20	45	18.27	CHANGED	+VLp-PsCFSDYIpsSTCEWchsussNCSupLpLsYpL..F.hSENh.TClPENpu...uoVCVC+Mhh-p.VpsDsYpL-LWAspp.LWpuSFKPSppV	....chlp-.sCaSDYhut.TCcWKhsussNCSs.-LpLhYpL..a.......s...csh.oCVPENst......uus......ClC+lhh-shVssD.YpLcLauGppl...LWp.u.SFpPuppV.............................	0	1	6	10
+9071	PF09239	Topo-VIb_trans		Topoisomerase VI B subunit, transducer	Sammut SJ	anon	pdb_1mu5	Domain	Members of this family adopt a structure consisting of a four-stranded beta-sheet backed by three alpha-helices, the last of which is over 50 amino acids long and extends from the body of the protein by several turns. This domain has been proposed to mediate intersubunit communication by structurally transducing signals from the ATP binding and hydrolysis domains to the DNA binding and cleavage domains of the gyrase holoenzyme [1].	20.50	20.50	21.20	28.80	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.93	0.71	-4.70	36	213	2012-10-03 01:04:38	2006-08-22 09:42:12	6	7	190	20	129	216	138	155.40	40	26.23	CHANGED	Ps.sssLSPIGE-hIcpGLcc....hps-Fluu.lTRpPpsYuGp.PFlVEsGIAYGGcl...sps..psplhRFANRlPLLYcpGuCslTc.slc..slsW+pYslcpst......uPlllhVHlsSTpVPapSsuK-uIA....-lPEIccEl+lAlpcsuRcL+paLs++c+tcctcc+	........................PssssLSPIG--.lctGlcc....hp.P-.Flss.hT........RpPpsYpGp.PFlVEsGlAYGGcl.....................spp........phplhRFANRlPLLa-pGusslTc.s...lc..plsW+p.Ytlcpst......uPlslhVHlsSTplPapStuK-uIA....clsEItcEl+hAlpcsuRcLcpals++cptpctpc+.............................	0	41	82	109
+9072	PF09240	IL6Ra-bind		Interleukin-6 receptor alpha chain, binding	Sammut SJ	anon	pdb_1n26	Domain	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6 [1].	23.10	23.10	23.20	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.63	0.72	-3.83	23	523	2012-10-03 16:25:20	2006-08-22 09:59:09	5	17	48	40	212	691	0	94.90	22	19.27	CHANGED	ssp..sLpChh+s...........hphlpCoWpsGtsssssspYsLaahapshppstp.....Cppahpsp.t.........phuCphsh.ph..sthp......pahlpVsuoSpsuslpst.pshphpsl	....................sp.slsChhps............hphhpCoWpsGp..s..ss...s..T.pYsLahph.ps.....p..pt.pp.......Cpph...hpsp...t............phuCphsh.p..h..p..ht......phhltlpspsttt.lps...hh......................................................	1	12	21	54
+9073	PF09241	Herp-Cyclin		Herpesviridae viral cyclin	Sammut SJ	anon	pdb_1bu2	Domain	Members of this family of viral cyclins adopt a helical structure consisting of five alpha-helices, with one helix surrounded by the others. They specifically activate CDK6 of host cells to a very high degree [1].	25.00	25.00	217.10	216.80	23.60	18.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.52	0.72	-3.75	3	3	2009-01-15 18:05:59	2006-08-22 10:12:15	5	1	3	5	0	5	0	106.00	81	41.30	CHANGED	AVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL	AVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL	0	0	0	0
+9074	PF09242	FCSD-flav_bind		Flavocytochrome c sulphide dehydrogenase, flavin-binding	Sammut SJ	anon	pdb_1fcd	Domain	Members of this family adopt a structure consisting of a beta(3,4)-alpha(3) core, and an alpha+beta sandwich. They are required for binding to flavin, and subsequent electron transfer [1].	21.50	21.50	22.20	21.50	20.20	21.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.37	0.72	-4.02	53	230	2009-09-11 08:59:02	2006-08-22 10:22:50	6	6	178	2	112	249	205	70.00	30	16.54	CHANGED	Pss.shhsNTCYSllu..PchuloVAuVYchsssp..lhslpG.......loshssssshpppEAphAhuWYpsIopDhaG	..........shhsNTCYShlu..scpulpVuulYchsssp.....lsplsG.....hhpsss...tsss.hp.ptcuphAhuWhpsIhsDhaG.........	0	28	69	89
+9075	PF09243	Rsm22		Mitochondrial small ribosomal subunit Rsm22	Mistry J, Wood V	anon	Pfam-B_8789 (release 20.0)	Family	Rsm22 has been identified as a mitochondrial small ribosomal subunit [1] and is a methyltransferase.  In Schizosaccharomyces pombe, Rsm22 is tandemly fused to Cox11 (a factor required for copper insertion into cytochrome oxidase) and the two proteins are proteolytically cleaved after import into the mitochondria [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.89	0.70	-5.37	7	679	2012-10-10 17:06:42	2006-08-22 11:14:57	5	14	492	0	408	777	58	228.70	20	53.83	CHANGED	chsshAYhAtRhPuTYAAV+uuLcuhApusPpFsPtShLDlGuGsGsuhWAssphWs.chppshhl-tStshhslGpplAtcssthppshhttshhhthlph..s.....DLVTluYVLsELss.spRptll-pLWstssp..hlVIVEsGTPsGapRll-ARctL....IAtGh+lsAPCPHshsCPlsss....DWCHFStRVu..RSplHRhsK....suplsaEDEKFsY..lAAsRtssuss...............ssRVltPPpltuG+VllcLCppDtphpcplsTK.R..............cG.tha+tARcucWGDta.	....................................................................................................................................t.....ah.......a...t.h.t.h.th....................................t......h..................s.t........p...h.h.DhGsG..........u.s...s...h.....h...........sh.......t....t....h..........h......t....................h...................p.................h............h.......h...l...-..........s........h........t.....hu.t..l..h....t....t.........................................................................................h....t..........................................Dll.hhsas.L....c......l...........................t.............t......c.........t.......t........h......lpph..h..t..h..h.t............hlll...lE....Gs.t..G.aphl.h..ts.Rphl................................tt.....h.hlhAPCsp..t..............C.....P.h......................................C.p..F....t..h..........................................................pt.....t..asa....l....h....h..p....................................................................................hsRlh...s.h.tttth.hphC......t...................tt........h...tt...hst..p...........................................t.......a.....h+....Gs.................................................................................................................	0	139	251	353
+9076	PF09244	DUF1964		Domain of unknown function (DUF1964)	Sammut SJ	anon	pdb_1r7a	Domain	Members of this family of bacterial domains adopt a beta-sandwich fold, with Greek-key topology. They are C-terminal to the catalytic sucrose phosphorylase beta/alpha barrel domain, and are functionally uncharacterised [1].	21.80	21.80	24.00	73.30	21.70	16.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.40	0.72	-3.64	3	41	2009-01-15 18:05:59	2006-08-22 11:24:14	5	1	40	6	7	34	4	68.70	68	13.57	CHANGED	AFDG-FSYoVDDDTSIoFoWsGt..TSpATLTFEPuRGLGVDNsTPVAoLsWoDSAGDHRTDDLIANPPV	AFDG-FSYpsDGDTSIoFpWpus..sooAsLTFEPG+GLGsDNsssVAoLsWoDuAGDHcTDDLlANPPl.	0	1	2	3
+9077	PF09245	MA-Mit		Mycoplasma arthritidis-derived mitogen	Sammut SJ	anon	pdb_1r5i	Domain	Mycoplasma arthritidis-derived mitogen (MA-Mit) adopts a completely alpha-helical structure consisting of ten alpha helices. It is a superantigen that can activate large fractions of T cells bearing particular TCR V-beta elements. Two MA-Mit molecules form an asymmetric dimer and cross-link two MHC antigens to form a dimerised MA-Mit-MHC complex [1].	25.00	25.00	62.90	62.70	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.65	0.70	-5.06	2	5	2009-09-11 16:59:48	2006-08-22 11:50:13	5	1	2	8	2	9	0	165.60	79	87.34	CHANGED	SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNKEETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNMMFLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLSYFISQNKNFQELWDKAVKLTKEMKIKLKGQKL.............................................................D	SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNK.EETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNMMFLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLSYFISQNKNFQELWDKAVKLTKEMKIKLKGQKLDhhDs.sslNpVcchFGuDcsVKplhWF+SLLl+us.hlh+YY-us..hpspoDFtKAlFE..	0	0	2	2
+9078	PF09246	PHAT		PHAT	Sammut SJ	anon	pdb_1oxj	Domain	The PHAT (pseudo-HEAT analogous topology) domain assumes a structure consisting of a layer of three parallel helices packed against a layer of two antiparallel helices, into a cylindrical shaped five-helix bundle. It is found in the RNA-binding protein Smaug, where it is essential for high-affinity RNA binding [1].	21.50	21.50	21.60	23.90	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.48	0.72	-4.44	4	24	2012-10-11 20:01:01	2006-08-22 12:56:51	5	1	23	1	19	32	0	110.20	45	11.80	CHANGED	RhslL.RlEpDLl..uGQ.hpLSTslEELTNIVLTPMKPlt.stP..EsIutpFlKVlDLVushl.tcPhC.sQD-EshsVFhWIL-RulHN-AFhsHusQLK-hKaKlSKl	................................RhphL.+lEp-Lh...........sGp.hp....LusslEELTNIVLTPMKPl.......ps.ssP....EsIuhpFlKVlDlVs..stLtt-Phs.sQDDEsLsVahWIL-RulHN-AFhsHssQLK-hKaKlsKh.............	0	4	5	16
+9079	PF09247	TBP-binding		TATA box-binding protein binding	Sammut SJ	anon	pdb_1tba	Domain	Members of this family adopt a structure consisting of three alpha helices and a beta-hairpin. They bind to TATA box-binding protein (TBP), inhibiting TBP interaction with the TATA element, thereby resulting in shutting down of gene transcription [1].	25.00	25.00	25.20	25.20	23.90	24.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.95	0.72	-3.76	8	130	2009-01-15 18:05:59	2006-08-22 13:12:45	6	18	84	1	77	139	0	63.20	49	3.73	CHANGED	SDuDs-p-s....shsLsGFLFGNIDpsGcL-sDsh........LDcEuKcHLuuLuchGLuShLsEl........hssc-t	...........sp-p-t-p.........shs.LsGFLFGNIspsGpLEsDsl........LDs.......EsK+HLAuLu.s.L.GLGSLloEl........sus--....................	0	21	33	53
+9080	PF09248	DUF1965		Domain of unknown function (DUF1965)	Sammut SJ	anon	pdb_1n9e	Domain	Members of this family of fungal domains adopt a structure that consists of an alpha/beta motif. Their exact function has not, as yet, been determined [1].	29.20	29.20	31.50	30.20	28.40	29.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.44	0.72	-4.07	7	53	2009-01-15 18:05:59	2006-08-22 13:32:51	5	7	42	7	41	57	0	73.70	35	9.63	CHANGED	FDspoLlPhGLaFpSDlTGRDPSpWpL.GWlYNshFYpTTEEFRpAaaSssFsKhtPNl-...GsWutTDppGsl.P	..........sLlPlGLahthDlTGRDPSp..WplhGalYsspFYpTs-cFRpAahsssF.p+.h.ssshs....GsWutpsppGp..........................	0	16	26	36
+9081	PF09249	tRNA_NucTransf2		tRNA nucleotidyltransferase, second domain	Sammut SJ	anon	pdb_1r89	Domain	Members of this family adopt a structure consisting of a five helical bundle core. They are predominantly found in Archaeal tRNA nucleotidyltransferase, following the catalytic nucleotidyltransferase domain [1].	21.90	21.90	21.90	22.10	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.60	0.71	-4.20	41	166	2009-09-11 09:45:38	2006-08-22 13:58:42	6	5	161	44	104	174	43	112.60	42	25.93	CHANGED	D-VRLLKpFhKulGVYGuEl+spGFSGYLsELLllpYGuFpslLcuAu.pW+s.shhI-hp.......p.hcpF............ccPLlVlDPVDPpRNVAAAlShcshupFlhtuRtFL.cpPShsaFhs	...................--VRLLKpFhKulGlYGuEl+spGFSGYLsELLllcYGuFpslLcsAu.pW+..shhI-hp............t..p..ppF...............ccPLlVlDPVDPpRNVAAulShcshupFhhtu+paLc.pPuhpaFh.....................	0	26	61	84
+9082	PF09250	Prim-Pol		Bifunctional DNA primase/polymerase, N-terminal	Sammut SJ	anon	pdb_1ro2	Domain	Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.83	0.71	-4.26	98	956	2009-09-11 10:28:24	2006-08-22 14:21:46	6	32	635	4	284	971	283	175.10	18	37.07	CHANGED	Ahthh.pp.GhsVhPl.....................sssKpPh................................hpsappss.p.....c.pplpp..hap......t.......................................shslulhs.............ssllllDlDsps...............................slpthtt..........thlss.....sh......sspT....sps.................GtHhaaphsss..............htt......................t..lD....l.tsss.sa............l..ls.......s.......PShp....sss....Yp......hh.....................................hsshP...........thL	............................................................hh.tt.Ghs.lh..Ph................................s.ssKtPh.....................................................hpshp.pso..s..............s.p.plpp...ahp...ph.....................................ssss.lulhs......................t.sshhllDlDsts..........................s.t...................................slpphtp...........h.hthlss.......sh..sstTsss......................................Gt.Hha.ap..h..stsh........h.pphhhh...........................................su...l-....l..p....u.p...s...sa............l..ls..s..PSht.............sts.....Yp.........h.tt...............................................................................................................	0	86	198	257
+9083	PF09251	PhageP22-tail		Salmonella phage P22 tail-spike	Sammut SJ	anon	pdb_1tyv	Domain	Members of this family of viral domains adopt a structure consisting of a single-stranded right-handed beta-helix, which in turn is made of parallel beta-strands and short turns. They are required for recognition of the 0-antigenic repeating units of the cell surface, and for subsequent infection of the bacterial cell [1].	25.00	25.00	127.50	127.30	18.20	17.40	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-12.76	0.70	-6.24	6	48	2012-10-02 14:50:22	2006-08-22 14:45:56	5	2	44	23	0	51	0	509.60	79	82.26	CHANGED	phEADKKFKYSVKLSDasTLQshAsAAVDuLLIDlDYpFoNGETVDFGGKsLTIDCKAKFIGDGNLlFTpLGpGSlVtuPFMESsTTPWVIhPWT-DspWITDAAAVVATLKQSKT-GYQPTVNDYVKFPGIEoLLPspAKsQsIsSTL-IRECoGVEV+RASGLMAsaLFRuCHaCKMlDuDs..GGKDGlITFENLSGDWGhGNYVIGGRTsYGSVSSsQFLRNNGGhu+DGGVIGFTSYRAGESGVKTWQGTVGuTTSRNYNLQFRDSlsL.PVWDGFDLGADssMsPEsDRPGDaPlSQYPlHQLPhNHLIDNLLVhGSLGVGlGMDGpGhYVSNITVpDCAGSGuhhhTappVFTNIulIDTNThNFsAsQIYIpGsChVNGLRLlGI+sTsupGhsIDAPNSTlSGITG.VDPSRINVANLh-.sLGNoRINSFNsDSAuLclRIHKLSKTLDSGAlhSHlNGGsGSGSAWTElTAISGSsPDAVSLKlNRGDaRAsEIPlusolLPDsAV+DpuohuhYhEss..SLKALVK+sDGShTRlTLA	........SIEADKKFKYSVKLSDYsTLQDAASAAVDGLLIDlDYpFYsGEpVDFGGKsLTI-CKAKFIGDGNLIFTKLGKGSRIAGVFMESTTTPWVIKPWTDDNQWLTDAAAVVATLKQSKTDGYQPTVSDYVKFPGIETLLPPNAKGQNITSTLEIRECIGVEVHRASGLMAGFLFRGCHFCKMVDANNPSGGKDGIITFENL.SGDWGKGNYVIGGRTSYGSVSSAQFLRNNGGFERDGGVIG.FTSYRAGESGVKTWQGTVGSTTSRNYNLQFRDSVVIYPVWDGFDLGADTDMNPELDRPGDYPITQYPLHQLPLNHLIDNLLVRGALGVGFGMDGKGMYVSNITVEDCAGSGAYLLTHESVFTNIAIIDTNTKDFQA.NQIYISGACRVNGLRLIGIRSTDGQGLTIDAPNSTVSGITG.MVD.P.SRINVANLAEEGLGNIRANSFGYDSAAIKLRIHKLSKTLDSGALYSHIN.GGPGSGSAaTQLTAISGuTPDAVSLKVNHpDsRuAEIPFsPslsSD-hlKDuSCFlPYWEsN.sSLKALVKKPNGpLVRLTLA.......	0	0	0	0
+9084	PF09252	Feld-I_B		Allergen Fel d I-B chain	Sammut SJ	anon	pdb_1puo	Domain	Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide [1].	24.00	24.00	25.10	24.80	22.80	21.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.03	0.72	-4.07	10	38	2012-10-01 20:54:19	2006-08-22 16:24:57	5	1	15	6	15	64	0	66.30	42	64.32	CHANGED	ClPFFcuYuuVloGu+laLpp-LStFNATstE+sAaEKIQDCapEpGlKoKlL-splMtollhSsEC	.................ChsFassYsullsGs+hhLptpLuhFsATssE+sAaEKIQDCasEpGL+sKlh-splMholhhSsEC.....	0	0	0	0
+9085	PF09253	Ole-e-6		Pollen allergen ole e 6	Sammut SJ	anon	pdb_1ss3	Domain	Members of this family consist of two nearly antiparallel alpha-helices, that are connected by a short loop and followed by a long, unstructured C-terminal tail. They are highly allergenic, primarily mediating olive allergy [1].	25.00	25.00	28.90	28.90	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.46	0.72	-4.31	3	13	2009-01-15 18:05:59	2006-08-22 16:37:14	5	1	7	1	7	14	0	39.50	54	51.09	CHANGED	CYDsCQKECSDcGsGYTFCEMKCDsDCosK-lKEKIENL..Kp	CFssCccECpscGsG.TFCEMKCDTDChsK-lttKl......h........	0	0	5	7
+9086	PF09254	Endonuc-FokI_C		Restriction endonuclease FokI, C terminal	Sammut SJ	anon	pdb_2fok	Domain	Members of this family are predominantly found in prokaryotic restriction endonuclease FokI, and adopt a structure consisting of an alpha/beta/alpha core containing a five-stranded beta-sheet. They recognise the double-stranded DNA sequence 5'-GGATG-3' and cleave DNA phosphodiester groups 9 base pairs away on this strand and 13 base pairs away on the complementary strand [1].	25.00	25.00	25.00	25.20	23.60	24.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.96	0.71	-5.20	12	30	2012-10-11 20:44:45	2006-08-22 16:55:39	6	3	30	3	5	37	1	174.70	34	34.62	CHANGED	KsslpchKsclRcclsplsHcYLpLlDlAaDuK....pNR-...FEhhTh-Lhhp.hsFcGh+LGGoRKPDGllYpssh....GlIlDTKAYupGYsLsIsQADEMhRYl--NppRDcphNPN+WWEsFscsl..pp.ahFlaVSupFhGsFpcQLpphspcTsspGuAlsVppLLLhA-hl+sGchshp-hhchhpNs-Ihh	..........................phKt.hhpp.pplshpYlphl-lAacu+.....cs.p-...FEhhTh-LFps.htapup+LGG.u...pKPDsllassct....ulIlDoKAYucGYslshspsDcMh.RYIcpsppRccphsPs.WWc.asppl..sp.haFhalSupFsupacpQLpphspcTshpGuAlsVtpLLlhA-phpptphshcclhchhpsppl............	0	3	3	5
+9087	PF09255	Antig_Caf1		Caf1 Capsule antigen	Sammut SJ	anon	pdb_1p5v	Domain	Members of this family are predominantly found in the F1 capsule antigen Caf1 synthesised by Yersinia bacteria. They adopt a structure consisting of a seven strands arranged in two beta-sheets, in a Greek-key topology, and mediate targeting of the bacterium to sites of infection [1].	25.00	25.00	27.80	27.00	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.70	0.71	-4.27	2	29	2009-01-15 18:05:59	2006-08-22 17:09:56	5	1	20	15	1	24	0	107.20	85	82.49	CHANGED	VEPARITLTYKEGuPITIMDNGNIDTELLVGTLTLGGYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQDFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ	.VEPARITLTYKEGAPITIMDNGNIDTELLVGTLTLGGYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQDFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ	0	0	1	1
+9088	PF09256	BaffR-Tall_bind		BAFF-R, TALL-1 binding	Sammut SJ	anon	pdb_1oqe	Domain	Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 13c, BAFF-R, are required for binding to tumour necrosis factor ligand TALL-1 [1].	21.00	21.00	21.20	22.40	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.64	0.72	-4.36	2	31	2009-01-15 18:05:59	2006-08-23 09:17:39	5	1	22	70	15	30	0	31.00	57	17.37	CHANGED	PT.Cs.sECFD.LVRpCVuCtLh+TPcst.u	....PTpCspuECFDPLVRpCVuC.cLh+T..Pcst..........	0	1	1	3
+9089	PF09257	BCMA-Tall_bind		BCMA, TALL-1 binding	Sammut SJ	anon	pdb_1oqd	Domain	Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 17, BCMA, are required for binding to tumour necrosis factor ligand TALL-1 [1].	22.40	22.40	23.40	51.20	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.15	0.72	-4.00	2	32	2009-09-10 15:58:20	2006-08-23 09:26:21	5	2	24	12	15	30	0	37.40	77	22.05	CHANGED	C.psEYFDSLLHAChPCpLRCSs..PPhTCQ.YCssSVT	.C.QNEYFDSLL+ACKPCpLRCSs.TPPLsCQRYCNAS.....	0	1	1	2
+9090	PF09258	Glyco_transf_64	EXTL2; 	Glycosyl transferase family 64 domain	Sammut SJ, Bateman A	anon	pdb_1omz	Domain	Members of this family catalyse the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate [1].	20.60	20.60	20.60	21.00	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.82	0.70	-5.22	25	640	2012-10-03 05:28:31	2006-08-23 09:38:24	5	15	149	8	394	576	20	229.70	37	40.08	CHANGED	FTlllhs.....hsRtphLh+llppl..ussshlspIlVlWss.scssPpp...........pphsssu.VPlpllc.................sppsslssRFhPassIcT-AVLulDDD.shlsss-lcFAFpVWp..sFP-RlVGassRtHh.hD...spspWsYso........paoscYSMVLTGAAFaH+hY.hpLYo...phhPpulRshVDcptNCEDIhMNFLVushTppPP....lKVs......ph+papcstsst..............suhsucss..H.htpRspClNpFuchaG..hMPLhtoph+h..ssshF	.............................................FThlhhs......hpR.psLhphlpph.............sts.s........l.ppllVlWNs...s...cssPtp........................phs..sht..lPl..hll.p..........................spp....ssl.ssRFhPa....s..........pIc....T-A..VLulDD.D..s.hl.ss.s-lpFuFpV.......Wp.........pa..P-.R.l..V.G..as..s.RhH.......h..aD...........spp...pWtYso....................pho.sphSMVL.TG...AAFaH+.hY.hh.LYo...phhPt..s.l...+s.hVDph.h.........NCEDIh..MN.FLVup...lT.tpsP......................l.K.Vs........ttpac..pstsst........................uh.tcss...H.hhpRppClNpFsp.haG..hMPLhhoph+h..-.hha.................................................................................................	0	136	195	290
+9091	PF09259	Fve		Fungal immunomodulatory protein Fve	Sammut SJ	anon	pdb_1osy	Domain	Fve is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like beta-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions [1].	25.00	25.00	169.00	168.80	24.50	22.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.47	0.71	-4.14	2	8	2009-01-15 18:05:59	2006-08-23 09:52:28	6	1	6	5	1	8	0	109.50	72	95.01	CHANGED	SsTuLhFpLAa.VKKlsFDYTPNWGRGsPssaIDslTFPKVLTDKtYoYRVsVsGpsLGVcssaAVpssGuQplNFLpYNpGYGlADTpTIQVFVV.PDTsN..-aIIApW	..SDTALlFpLAWsVKKLSFDYTPNWGRGsPSSaIDNlTFPKVLTDKAYTYRVVVSG+DLGV+PSYAVpSDGSQKlNFLEYNsGYGIADTNTIQVFVVDPDTGN..-FIIAQW	0	0	1	1
+9092	PF09260	DUF1966		Domain of unknown function (DUF1966)	Sammut SJ	anon	pdb_7taa	Domain	This domain is found in various fungal alpha-amylase proteins. Its exact function has not, as yet, been defined [1].	21.30	21.30	21.30	21.60	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.95	0.72	-3.90	39	219	2012-10-02 20:10:03	2006-08-23 11:03:31	6	7	96	10	148	223	0	86.70	32	16.21	CHANGED	slYpDs........sslAhRKGs.tGtQllsVLoNpGo........uusYslslss..sGasuGsslh-lloCsshTs....sssGslsVsMsu....G.P+VahPsshhtGSGLC	.................lap-s........sslAhRKGs.tGtpllsVloNtGu.s........ussaslsls.....suass.Gppls-lloCs.s..hos....sssGslsVshss....G.P+.VhhPssh.h.u.SulC.............	0	45	74	117
+9093	PF09261	Alpha-mann_mid		Alpha mannosidase, middle domain	Sammut SJ	anon	pdb_1o7d	Domain	Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase [1].	20.90	20.90	21.00	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.92	0.72	-3.77	126	2561	2009-01-15 18:05:59	2006-08-23 11:25:36	6	27	1449	64	839	2123	87	78.00	28	8.09	CHANGED	EaHpGhaTSpsp.....hK+hsRpsEphL.pssEhlsshusht........tt.........ttplpplW......................cslhlsQaHDslsGouhppVhp.Dhtpch	......................................hapGhho.S..+ht.....hKphsRcsEp.h.L....ps.s.E.LsshAtht.................................th....th.........pppLpp.h..W......................+plhhsQaHDulsGouhspVhc-hhtc..............................	0	291	479	678
+9094	PF09262	PEX-1N		Peroxisome biogenesis factor 1, N-terminal 	Sammut SJ	anon	pdb_1wlf	Domain	Members of this family adopt a double psi beta-barrel fold, similar in structure to the Cdc48 N-terminal domain. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation [1].	19.50	19.50	21.20	19.60	18.80	16.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.78	0.72	-3.93	32	271	2012-10-01 20:15:13	2006-08-23 11:53:34	6	14	244	1	190	278	1	81.00	35	7.38	CHANGED	AppVplEPlTscDWEllEhpAphlEs.plLsQlRslhs.............sphlslal..sssossplpVspltPssst..................hu+lsssoEllVAP	.....sppVplEPlos-DWE....IlELHAphlEp.pLLsQlRlV.s.............sphlslal........sssossplplsslpPsss....................hu+lsssoEllVAP...............	0	53	95	152
+9095	PF09263	PEX-2N		Peroxisome biogenesis factor 1, N-terminal 	Sammut SJ	anon	pdb_1wlf	Domain	Members of this family adopt a Cdc48 domain 2-like fold, with a beta-alpha-beta(3) arrangement. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation [1].	25.00	25.00	29.70	32.80	21.60	20.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.94	0.72	-3.68	2	52	2009-01-15 18:05:59	2006-08-23 11:54:29	5	4	36	1	28	53	0	83.50	64	7.17	CHANGED	GAVVolthTss+DsFh+Ls.cllAQL+L.QNpAlEVu.scQ.PsYLsWhEuRphss.upNVAElNRQhupKLGhSpGpQVFL+.Cop	....ssVTVsFTNARDCFLHLPp+LVuQLHLhQNQAIEVsWucQ.PsFLSWVEGRHhocp....GENVAEINRQlGQKLGLSsGpQVFL+PCoH.....	0	3	5	12
+9096	PF09264	Sial-lect-inser		Vibrio cholerae sialidase, lectin insertion	Sammut SJ	anon	pdb_1w0p	Domain	Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme [1].	25.00	25.00	36.90	35.40	18.60	16.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.09	0.71	-4.98	2	111	2009-01-15 18:05:59	2006-08-23 12:46:17	5	8	55	9	4	48	0	178.40	52	44.74	CHANGED	DVTcQVKE+SaQIAGWGGSELYp+ssoLNSpQDWQ.NAplRIhDGAANpIQsADGuRpaVVThulD.SGtLsApLNG.SuPlllt.ppucVauFHpYpltYSALsppsoLhVDGpplsoWuGEsSppN.lpFGNADuplDGRlHlQcIsLpQpGhsLVphDAhYLAQQsP.psppDLEpLGWoK.KoGNTMShYGpAS	....................................................................p...ppp.u.s..Sp.sWp.ssch+llsGuh.p..hAsGop+hlshlSlDpSGsLVsphpG.ou.hlLtotpAt.ppaHcaEL.a.s.h.sp.osohahDGphIp.s...pspsSppN.I.aGNusuphDGhhthpcIthp.QGcs...................................................................	0	2	2	4
+9097	PF09265	Cytokin-bind		Cytokinin dehydrogenase 1, FAD and cytokinin binding	Sammut SJ	anon	pdb_1w1o	Domain	Members of this family adopt an alpha+beta sandwich structure with an antiparallel beta-sheet, in a ferredoxin-like fold. They are predominantly found in plant cytokinin dehydrogenase 1, where they are capable of binding both FAD and cytokinin substrates. The substrate displays a 'plug-into-socket' binding mode that seals the catalytic site and precisely positions the carbon atom undergoing oxidation in close contact with the reactive locus of the flavin [1].	20.50	20.50	20.70	20.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.94	0.70	-5.26	18	278	2012-10-02 00:48:38	2006-08-23 13:02:20	5	5	80	16	137	330	2	242.40	36	52.73	CHANGED	Pp+VRWlRllYoDFssFTcDQEhLIShpss.t.......hDYVEG.lhls.puhhsshpos..............FsPsD.s+luslss..sutVlYCLEsshaYc........ss...s.ssshDQcl-sLhppLsaltGhlFppDVsYh-FLsRV+ppEhpLRupGLW-VPHPWLNLFVP+SpItcFccuVFcuI.Lpssss.GPlLlYPhN+sKWDs+hSslhP.-...E-VFYhVGlLpSu.....suhssl-cLpppNccIlcFC......c..puGIshKQYLPaa..sopp-..W.p+HFG.s+WsRFsc+KscYDP+sILuPGQpIF	..............................................................PthV+WlRhlYssFstFotDQEhLluh.tt.........hDYlEG.lhhs....p..s..ssh......ss..................h.sstp...phsth.t....tuth..lYsL..Ehsh.as..............tt...p..tsshs....pclptlLtpLpah.uhhFtpDlsYh-FLsRV+t.tE.pLRupGhW-.V.P.HP..WLNLFlP.......cSpItcFsptVFpsl.L.pp..s...s...s..........G.PlL.lYPhs+.sKWDsph.Ss...sh.P..-.......--lFYhVuhLpou............sssslcpl.ppNpcIlchC........p..tsslthK.pYLspa....popt-..W.tpHFG....s+WppFhptKtpaDPhtILuPGQtIF.................................................................	0	23	81	113
+9098	PF09266	VirDNA-topo-I_N		Viral DNA topoisomerase I, N-terminal	Sammut SJ	anon	pdb_1vcc	Domain	Members of this family are predominantly found in viral DNA topoisomerase, and assume a beta(2)-alpha-beta-alpha-beta(2) fold, with a left-handed crossover between strands beta2 and beta3 [1].	25.00	25.00	43.80	43.70	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.61	0.72	-4.09	13	69	2009-01-15 18:05:59	2006-08-23 13:10:41	5	2	45	4	0	56	0	57.70	68	18.51	CHANGED	haYpDGKLFpDKphop.Vsp..DNPsYEILK+lKIPsHLoDVlVYEQTaE-AhspLIFVG	.LFYKDGKLFsDssFhNPVSD..DNPAYEVLpHVKIPoHLTDVVVYEQTaEEALTRLIFVG	0	0	0	0
+9099	PF09267	Dict-STAT-coil		Dictyostelium STAT, coiled coil	Sammut SJ	anon	pdb_1uur	Domain	Members of this family are found in Dictyostelium STAT proteins and adopt a structure consisting of four long alpha-helices, folded into a coiled coil. They are responsible for nuclear export of the protein [1].	20.70	20.70	21.40	21.40	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.54	0.71	-3.86	3	15	2009-01-15 18:05:59	2006-08-23 13:26:01	5	3	4	2	15	17	2	109.90	33	13.48	CHANGED	QpILNEIaKLphpQ+ETL-KMhIsQKQlLu+hssshspNscEsL+SLss-QsTLuuQl-oEloALsQlcpshILEPs-LsKLhhLLQDLoIQhKQLcLYHpELQhllsPQcPsP	..........................................p.llsphh+Lh.tQcppL.pMhh.QpplLsc................hspsp.hphhptLpscQsTL+pQI-sEhouLpplhpphIL-Ps-LpKlhhLlp-LpIQh+QLcLhHpELQhllsPppP.........	2	12	15	15
+9100	PF09268	Clathrin-link		Clathrin, heavy-chain linker	Sammut SJ	anon	pdb_1utc	Domain	Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain [1].	20.60	20.60	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.46	0.72	-6.38	0.72	-4.87	17	470	2012-10-11 20:01:01	2006-08-23 13:48:23	5	23	355	13	187	307	3	24.00	68	2.26	CHANGED	-psIlPYlpspLpNs-LAl+lAsR	....EENIIPYITNVLQNPDLALRMAVR.	0	59	97	144
+9101	PF09269	DUF1967		Domain of unknown function (DUF1967)	Sammut SJ	anon	pdb_1udx	Domain	Members of this family contain a four-stranded beta sheet and three alpha helices flanked by an additional beta strand. They are predominantly found in the bacterial GTP-binding protein Obg, and are still functionally uncharacterised [1].	20.70	20.70	21.20	22.10	20.50	18.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.02	0.72	-4.31	110	2054	2009-09-11 09:14:44	2006-08-23 14:07:22	6	7	2030	1	404	1340	191	69.80	42	15.64	CHANGED	Fpl...p+..csss..........hahVpGpclERhlphTshs.scEulthhtctLcphGVc-tLcctGsc.sGDtVpI..s....chpF-a	....................FpI..pR..-s..Du.......salloGp+lE+hhphTsFs.pD......EultpFA+pL+phGV--uL+.cpGA+.sGDhV+Is.....sh.EFEF........	0	162	293	361
+9102	PF09270	BTD	Beta-trefoil;	Beta-trefoil DNA-binding domain	Sammut SJ	anon	pdb_1ttu	Domain	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) [1].	25.00	25.00	32.90	26.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.13	0.71	-4.48	7	243	2009-01-15 18:05:59	2006-08-23 14:47:35	5	7	119	7	151	235	0	146.30	56	27.06	CHANGED	lCIspsopVuLFNRlRuQTVsT+aL..........................slEss......shtuustpWssFtlphh..........ss+sp.cchshp-G.hlpYGslVhLVsp.TGlt.PPlhl+KV-ptpulLss...s-PVSpLpKh....AFphp-....us+hYLslspc+l.p.....................hpss..sp..s+..lssGupW	..............LCIuSGoKVALFNRLRSQTVSTRYL..........................cVEsG............s..FpASopQWuAFhIH...Ll-........................Ds..c..u..puc-.......Fs.l.R-G...YI.+YGpsVcLVCoVTGhuLPhLIIRKV......D.KQpAlLD...........u....................D...............-PVSQLHKC....AF.hhD............scphYLCLS.pE+IlQ.....................FQ..AoPCP.KEsN+thlNDuusW.....................................................	0	61	71	112
+9103	PF09271	LAG1-DNAbind		LAG1, DNA binding	Sammut SJ	anon	pdb_1ttu	Domain	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1].  This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.	25.00	25.00	27.30	25.20	24.40	23.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.98	0.71	-3.70	12	251	2009-01-15 18:05:59	2006-08-23 15:01:53	6	6	119	7	155	234	0	132.00	55	24.73	CHANGED	slhlhHu+VAQKSYGsEKRFhCPPPhlYLhGsuW......pht....tp.hp...................tsh..sppu.....splsuahsluusst....phpphsh-st................hssA..KoLaISD.sD.KRKphpLtlphhh...........ssu....pcl......GhF.SphIKVISKPSKK+pohKss-	.................................................................TVhILHAKVAQKSYGNEKR.....F.FCPPP.CVYLhGsGW................+hK........ppph.pp......................................................pup...u-pt.............sp.CualGIGsusp.....-hQpLsh-s.t......................................................................passA..KTLYISD..oD.KRKHFhLsl+hah.....................................usu......c-l....................GsFhS+pIKVISKPSKKKQSLKNsD.....................................................................	0	64	75	116
+9104	PF09272	Hepsin-SRCR		Hepsin, SRCR	Sammut SJ	anon	pdb_1p57	Domain	Members of this family form an extracellular domain of the serine protease hepsin. They are formed primarily by three elements of regular secondary structure: a 12-residue alpha helix, a twisted five-stranded antiparallel beta sheet, and a second, two-stranded, antiparallel sheet. The two beta-sheets lie at roughly right angles to each other, with the helix nestled between the two, adopting an SRCR fold. The exact function of this domain has not been identified, though it probably may serve to orient the protease domain or place it in the vicinity of its substrate [1].	26.70	26.70	26.80	27.10	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.33	0.72	-3.83	2	55	2012-10-03 20:35:02	2006-08-23 15:58:54	5	4	32	6	24	43	0	105.50	65	25.71	CHANGED	sLapVQlSsuDpRLhVhDpTphpW+hlCSSpsNthlAslsCEEMGFlRAlsaS.hss.puG..GspsFFCVcEutLshup+lhssl.sCcCs+GphLpshCQDCGRRhLP	...............LYsVQVSsuDuRLhVFDcTEGTWRL.LCSS.RSNuRVAGLSCEEMGFL......RA.L.sHSE..LDVRTAG.ANGTSGFFCVDEGcLPaup..RLL-VIS.VCD.CPRGRFLsslCQDCGRR.KLP.................	0	1	3	9
+9105	PF09273	Rubis-subs-bind		Rubisco LSMT substrate-binding	Sammut SJ	anon	pdb_1p0y	Domain	Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.43	0.71	-4.22	43	613	2009-01-15 18:05:59	2006-08-23 16:27:20	6	17	220	26	433	611	10	124.40	18	24.97	CHANGED	lspsD.hhtp....KtplLcptGhsss..t.hslthsss.........hstcLLsaLRllshsspchtthtsstpstsh................slStpN............EtpshphltshspthLspYsTTlc-.Dct..hlcp...sshptp..................tphAlplRhsEKcIL	.............................................................................+.phlt.....p..s.....h.tp.......h.lthst....................s.pLlsh.LR.lhth.s.t...p...ch..p.ph.t.th.tts.......................................................h..u.ss......................................Etps.hp.h.L.tstsp.hhL.ppa.sT....o.l..cc.....Dpp.....lLpp....ts....ttp.............................................................tphAlplRhtEKplL....................................................................................	0	156	269	351
+9106	PF09274	ParG		ParG	Sammut SJ	anon	pdb_1p94	Domain	Members of this family of plasmid partition proteins adopt a ribbon-helix-helix fold, with a core of four alpha-helices. They are an essential component of the DNA partition complex of the multidrug resistance plasmid TP228 [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.52	0.72	-4.05	3	92	2012-10-02 18:44:02	2006-08-23 16:30:01	5	1	84	2	16	60	5	66.00	30	86.74	CHANGED	MALEKsHTSsKKMTFGEHRDLEKVVsSPlPSGKpKRVNVNFDEEKHTRFKAACAKpGTSITDVINQLVDNWLKENE	........................................................................stt.hKRVssNh..sE-hHpRhKhtCscpGpSIsDllspLl.cpaLpp...........	0	6	10	14
+9107	PF09275	Pertus-S4-tox		Pertussis toxin S4 subunit	Sammut SJ	anon	pdb_1prt	Domain	Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology [1].	25.00	25.00	254.40	254.10	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.55	0.72	-3.96	2	5	2009-01-15 18:05:59	2006-08-23 16:43:19	5	1	5	12	1	5	0	110.00	99	72.37	CHANGED	DVPYVLVKTNMVVTSVAMKPYEVsPTRMLVCGIAAKLGAAASSPDAHVPFCFGKDLKRsGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELIRMVECSGKQDCP	DVPYVLVKTNMVVTSVAMKPYEVTPTRMLVCGIAAKLGAAASSPDAHVPFCFGKDLKRPGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELIRMVECSGKQDCP	0	1	1	1
+9108	PF09276	Pertus-S5-tox		Pertussis toxin S5 subunit 	Sammut SJ	anon	pdb_1prt	Domain	Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology [1].	25.00	25.00	217.50	217.30	20.60	17.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.30	0.72	-4.02	2	5	2009-01-15 18:05:59	2006-08-23 16:44:09	5	1	5	6	1	8	0	97.00	96	75.90	CHANGED	PTHLYKNFTVQELsLKLKsKNQEhCLTAFMsGRSLVRACLSDAt+p+sTWFDTMLGFAISAYALKSRIALTVEDSPYPGTPGDLLELQICPLNGYCE	PTHLYKNFTVQELALKLKGKNQEFCLTAFMSGRSLVRACLSDAGHEHDTWFDTMLGFAISAYALKSRIALTVEDSPYPGTPGDLLELQICPLNGYCE	0	1	1	1
+9109	PF09277	Erythro-docking		Erythronolide synthase, docking	Sammut SJ	anon	pdb_1pzq	Domain	Members of this family of docking domains are found in prokaryotic erythronolide synthase. They adopt a structure consisting of a bundle of four alpha-helices, and mediate homodimerisation of the protein, stabilising the resulting complex [1].	24.60	24.60	25.00	25.00	23.60	24.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.86	0.72	-4.28	2	8	2009-01-15 18:05:59	2006-08-23 16:59:38	6	5	7	2	3	10	0	54.80	50	2.20	CHANGED	uA.PsVslGsRLD-LE+AL-ALsstpGHsDVGtRLEuLLRRWpSRRsstspsssIS-D	............slhscLDcLE+ALcALPsEDG.Hs-VusRLEuLLRRWpsRRAsAsus...............	0	1	2	3
+9110	PF09278	MerR-DNA-bind		MerR, DNA binding	Sammut SJ	anon	pdb_1q08	Domain	Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.01	0.72	-3.57	304	2740	2012-10-04 14:01:12	2006-08-24 08:59:03	6	15	1578	18	772	6957	665	64.40	30	43.61	CHANGED	lpRLphIppu+plGFoLsEI+plL....sl.......pp..t.spssschp..plhpp+ltclcp+lpcLpphcpp.Lpph	.............hcplthI+pAp.c.lG.hoLscI.tclL.....sL....................ps.....c..sts.s.p-..hc..........plu..p.p+....h....p....-.l.-...c....+I....p....p.Lp.thcsp.Lpth..........................................................	0	215	470	645
+9111	PF09279	EF-hand_like	efhand_like;	Phosphoinositide-specific phospholipase C, efhand-like	Sammut SJ	anon	pdb_1qas	Domain	Members of this family are predominantly found in phosphoinositide-specific phospholipase C. They adopt a structure consisting of a core of four alpha helices, in an EF like fold, and are required for functioning of the enzyme [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.76	0.72	-3.96	63	1479	2012-10-02 16:17:27	2006-08-24 09:12:10	6	79	244	26	795	1356	2	83.20	25	8.27	CHANGED	ElpplFppa.us.p...pphlospcLhcFLpccQ+csch........s.pcpstplIpc.....aEssp.....pspcc.......thlol-GFhpYLhSs-sslhssp+hcla	....................................-l..lh.ph...us...p.......pthlo.hppLhpF...Lp.pcQ..p.-sph.........................................s...ppstpl.Ipc.............a..Essp.......................ptppc...............................shloh-.GFhpYL.h.S.p.-.sslhsspp.pl..................................	1	179	275	510
+9112	PF09280	XPC-binding		XPC-binding domain	Sammut SJ	anon	pdb_1pve	Domain	Members of this family adopt a structure consisting of four alpha helices, arranged in an array. They bind specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair [1].	22.80	22.80	22.80	24.50	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.94	0.72	-4.51	36	513	2009-01-15 18:05:59	2006-08-24 09:22:59	6	13	297	12	316	512	7	58.10	44	15.62	CHANGED	Ls.hLpspPQFpplRphlQpNPplLpslLQplupsNPpLhph...Ippsp-tFlphLsp.ssss	.............L-FLRspPQFQplRpllQpNPp....lLtslLQQlGppNPpLhph.......IpppQ-pFlphLNE.ss..s............	0	95	163	247
+9113	PF09281	Taq-exonuc		Taq polymerase, exonuclease	Sammut SJ	anon	pdb_1qtm	Domain	Members of this family are found in prokaryotic Taq DNA polymerase, where they assume a ribonuclease H-like motif. The domain confers 5'-3' exonuclease activity to the polymerase [1].	25.00	25.00	76.00	74.10	21.90	21.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.89	0.71	-4.03	4	36	2009-01-15 18:05:59	2006-08-24 09:36:09	5	4	33	37	13	49	0	130.30	60	15.85	CHANGED	stPcE.A.hssPEGshhG.lLspscP....hhAphtA.tAsp-uch+RAs......Plsu.A-h...+EVpuhhAKsLAshhShcGssl-PGDDPLLlAYLLDPANTN..sVA+RY.ssEWsEDAApRAhlotRLhpsL.P+L	...............shEEAPWP.PPEGAFVGFlLSR.sEP....MWA-LhALAAAp-GRVH.RAss......PhtuLcDL...+ElRGlLAKDLAVLALREGlsLsPGDDPhLLAYLLDPSNTsPEGVARRY.GGEWTEDAucRALLoERLapsLh.RL......	0	3	8	13
+9114	PF09282	Mago-bind		Mago binding	Sammut SJ	anon	pdb_1rk8	Domain	Members of this family adopt a structure consisting of a small globular all-beta-domain, with a three-stranded beta-sheet and a contiguous beta-hairpin. They bind to Mago alpha-helices via extensive electrostatic interactions and at a beta2-beta3 loop via hydrophobic interactions [1].	20.60	20.60	20.60	25.60	20.20	18.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-6.79	0.72	-4.37	11	235	2009-01-15 18:05:59	2006-08-24 09:52:20	5	3	201	1	178	238	0	26.60	56	12.55	CHANGED	G-+hIPsopRsDGohRKsl+lRsGYhP	....Gp+aIsuopRPDGThRKthRV+sGYhP..	1	60	94	146
+9116	PF09284	RhgB_N		Rhamnogalacturonase B, N-terminal	Sammut SJ	anon	pdb_1nkg	Domain	Members of this family are found in prokaryotic Rhamnogalacturonase B, and adopt a structure consisting of a beta supersandwich, with eighteen strands in two beta-sheets. The exact function of the domain is unknown, but a putative role includes carbohydrate-binding [1].	27.00	27.00	28.30	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.51	0.70	-5.02	6	102	2009-09-11 00:34:51	2006-08-24 11:09:34	5	8	71	5	74	110	2	228.70	42	45.15	CHANGED	FGhTsoGssaslDuGus..LlFpVsKoosDlsSlpYRGsEhQ.YsuKuSHIuSGLGSATVosppluu....aIKVTssoSoL..THYals+sG-ssIYMAT.hsAEsslGELRFlARLpsshLPs..ptPaupVuTTtGsou.IEGuDVFll.sGpTRSKFYSScRFIDDchH......slSGuu..spVCMlhs..saEsSSGGPFFRDIsopssu-sssLYaYMNSGHVQTEuaRhGLHGPYulsFocuGsPssu....plDTSFFs.oLGIsG	........................FGhTpousphllDsGus..LsFsVs.psssDIsSlpYpusELQ.hpup.sSHIsSGLGo.u.o..V.shp..phss........hIhVosps.......u....s....L..spYhls+pGcssIYMAT.hsscsslG..ELRFlARLssshLPs....p.shussuss......s.ps.IEGsDVFhl.sGpTpSK....FYSup......RhIDDphH......sVsGsu...htVhhlhs...shEpSSGGPFFRDIssppssstppLY.Y..M.SsHsQT.....EsaRhG.LHGPYuhhFocuusPsss......l.DhuFhs.sLslpG..................................	0	30	45	66
+9117	PF09285	Elong-fact-P_C		Elongation factor P, C-terminal	Sammut SJ	anon	pdb_1ueb	Domain	Members of this family of nucleic acid binding domains are predominantly found in elongation factor P, where they adopt an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology [1].	25.00	25.00	25.20	27.80	20.20	23.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.56	0.72	-4.62	108	5622	2009-01-15 18:05:59	2006-08-24 11:26:27	6	9	4549	10	1133	2891	2007	55.20	50	29.52	CHANGED	VpLpVscT-PulKGsT.uoust.KPApLE.TG.hplpVPhFIppG-pIplcTcs.GpYlsR	.............V-Lcls-T-PGl.KG...DT...u...........o.u.us.KPATLc..T.....G.....hs.....lpVPhFlptG-hlclcTcs.GpYluR............	0	377	737	951
+9118	PF09286	Pro-kuma_activ		Pro-kumamolisin, activation domain 	Sammut SJ	anon	pdb_1t1e	Domain	Members of this family are found in various subtilase propeptides, and adopt a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptide [1].	20.90	20.90	20.90	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.64	0.71	-4.15	124	1063	2009-01-15 18:05:59	2006-08-24 11:45:25	6	31	332	4	629	1085	28	137.50	21	20.46	CHANGED	sshtphstssssph...l.p..lplsL.ppps..h..splcphlhpl..ssPssspY......................spa..LotpphtphauPsppslstVtsaLpstG.lsstp....................tsstphlshsuolupsc...............phh.ps..phthYp..................ssst.........hhhp..ssp..plPppls....................................shlshl....hs....hsph	..............................................t.......t.t.h.sssp.....l.p...lplsL....p.ps....h...sp..Lpphl...h.pl..ss.Psu.s.pY......................sc.a.....Lo..pphtphau.......Ps.sp......slstVtsaL.p..p...p....G...lsstp.............................ssspshlph.p.uolsps-...............phh.ss.....phptap....................tstp................hhhp.ss.p..hplPtplt....................................shlshl....hshp...................................................................	0	204	379	512
+9119	PF09287	CEP1-DNA_bind		CEP-1, DNA binding	Sammut SJ	anon	pdb_1t4w	Domain	Members of this family of DNA-binding domains are found the transcription factor CEP-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology [1].	17.80	17.80	18.30	17.80	17.60	17.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.42	0.71	-4.88	2	7	2012-10-03 00:25:27	2006-08-24 11:57:19	5	1	7	1	7	9	1	171.90	28	36.20	CHANGED	EcWhph-VhKp+suKsSDhtFthsspcthYLWsKMtC.lPh.VKWplsppH..ppL.L+lRhVpY.tp-NlE.uIRsP.SslhKC+sHp.pEp+hPh-SFFYlhpStccao..hsucKspsFshhhhPGssQs.FDlIFhCQcpCLDLs-RRKpMCLAVFL-DENGNElLHshIKQlhIVuYPRRDWKNFCE+csshp	.............h...hphpV.pt+stK.Ssh.....st.thhLWo+hts.lPh.lpWplspth...pppL.L+lRlVpY.tppslp.uI+ss.sslhKCpsHp.cEp+.hPh-uFFYlhsSspcas.....hs...p+.uppasshl.s..Gthp..ltFDlIFhCQcpChtlt-+RKphCLssFL-DE.tp.l.athlcplhlhuYPpRDhpNFp.+..............	3	2	3	7
+9120	PF09288	UBA_3		Fungal ubiquitin-associated domain 	Sammut SJ	anon	pdb_1tte	Domain	Members of this family of ubiquitin binding domains adopt a structure consisting of a three alpha-helix bundle. They are predominantly found in fungal ubiquitin-protein ligases [1].	20.40	20.40	20.40	20.50	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.58	0.72	-4.37	6	131	2012-10-01 23:03:33	2006-08-24 12:52:50	5	3	125	1	95	122	2	50.80	36	19.96	CHANGED	DEupLYGID+-lV-pFsuQGFE+sKllEsL+RLslKohs.sDNpTsN+IlEELLK	.................thh.Ghs+-LVDcFpsMGF-h-+VV-sh+hlGIcphss.s..................................	0	21	50	80
+9121	PF09289	FOLN		Follistatin/Osteonectin-like EGF domain	Sammut SJ, Bateman A	anon	pdb_1nub	Domain	Members of this family are predominantly found in osteonectin and follistatin and adopt an EGF-like fold [1,2].	21.10	21.10	21.50	21.20	20.20	21.00	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.79	0.72	-6.84	0.72	-4.09	14	363	2012-10-03 09:47:55	2006-08-24 13:32:02	5	12	89	21	133	310	0	21.90	49	6.20	CHANGED	CtNacCK+GKsCchscps+PhC	..CtNhpCttGKhCchsc.pscPpC	0	9	22	54
+9122	PF09290	AcetDehyd-dimer		Prokaryotic acetaldehyde dehydrogenase, dimerisation	Sammut SJ	anon	pdb_1nvm	Domain	Members of this family are found in prokaryotic acetaldehyde dehydrogenase (acylating), and adopt a structure consisting of an alpha-beta-alpha-beta(3) core. They mediate dimerisation of the protein [1].	25.70	25.70	26.10	32.80	19.20	25.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.82	0.71	-4.27	62	778	2009-01-15 18:05:59	2006-08-24 13:46:32	6	4	619	4	192	558	124	146.10	64	47.83	CHANGED	CGGQATIPlVtAlSRVs.sVcYAEIVASIAS+SAGPGTRANIDEFTcTTucAlEpVGGAp+GKAIIlLNPAEPPllMRDTVasLsc..ssD...pssIpsSlppMltcVppYVPGYRLKppspF-th....................+VolFL..EVEGAucYLP	.....CGGQATIPhVAAVSRVs.....pVpYAEIVASIAS+SAGPGTRANIDEFTcTTu+AIEsVGGAs+GKAIIlLNPAEPPLhMRDTVasLs-...-Ac.......p-sIpASIp-MsctVQsYVPGYRLKpcsQ.F.-shs.st............................hsth+suVaLEVEGAucYLP....................	0	45	122	164
+9123	PF09291	DUF1968		Domain of unknown function (DUF1968)	Sammut SJ	anon	pdb_1oga	Domain	Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.	25.00	25.00	36.80	36.30	22.90	17.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.80	0.72	-4.17	4	101	2009-01-15 18:05:59	2006-08-24 13:54:43	5	2	23	79	18	841	0	84.50	59	39.18	CHANGED	PAVYQL+DPpSsDpolCLFTDFDS.QsNVsp...StsSssalTspTVLDM+uMDSKSNGAlAWSNposFuCpssFp..NuohP.uDs..Ps	PAVYQLR..sspSSDpSVCLFTDFDS.QsNVSp...ScsS-ValTspTVLDM+uMDSKSNGAVAWSNpSDFuCpsAFp....NuslP.usoh.......................	0	1	1	2
+9124	PF09292	Neil1-DNA_bind		Endonuclease VIII-like 1, DNA bind	Sammut SJ	anon	pdb_1tdh	Domain	Members of this family are predominantly found in Endonuclease VIII-like 1 and adopt a glucocorticoid receptor-like fold. They allow for DNA binding [1].	25.00	25.00	27.00	25.80	18.50	17.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.05	0.72	-4.15	6	57	2009-01-15 18:05:59	2006-08-24 14:08:40	5	4	41	1	31	51	0	38.60	70	10.96	CHANGED	sYSsFcsWLpCYhVsGMsSLRD+NGRTIWFpGDPGPLAP	.DauAF+AWLpCYssPGMsSLRD+pGRTIWFQGDPGPLAP....	0	6	8	15
+9125	PF09293	RNaseH_C		T4 RNase H, C terminal	Sammut SJ	anon	pdb_1tfr	Domain	Members of this family are found in T4 RNaseH ribonuclease, and adopt a SAM domain-like fold, consisting of a bundle of four/five helices. These residues may have a role in providing a docking site for other proteins or enzymes in the replication fork [1].	25.00	25.00	25.30	27.10	22.80	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.42	0.71	-4.21	8	45	2012-10-01 19:52:02	2006-08-24 14:24:43	5	2	42	6	0	45	191	115.00	40	38.84	CHANGED	GSPcpDLhsKlIKGDtKDGVAuIKsRSDallT+VEGERAPsspsKhLEsl....h-sEDP+sLLTsEEa.pRacENpcLlDFDaIPDcIuspIlppYNo.KssPRuKlYsYFVKsuLsKLls+ls-F	................GosthDhhsKllKGD+KDsVAulKsRuDahho.+VEGERsPshpsphlEtl....h-p-pscsLlTc-p..a.pRacENphLIDFDaIPDsItspIlptYNshphs.s+uKlYsYFVKsuLsKLhspls-F.................	0	0	0	0
+9126	PF09294	Interfer-bind		Interferon-alpha/beta receptor, fibronectin type III	Sammut SJ	anon	pdb_1n6u	Domain	Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.62	0.72	-4.00	96	681	2012-10-03 16:25:20	2006-08-24 14:40:10	5	13	59	57	291	719	22	99.50	21	28.34	CHANGED	TplGPPp.lpl...pstssslplslpsP.......pspthohpslas.phtYplhhacsu..ss....cppthpsspsh.hlpsLpPtosYClpVpu.......ths+pu.hSphpChpTs	..............................................luPPt.lpl...ps.ssslplplpsP...............tttths.......h.....p.......phas.......t....h.....p.Y...plh.....hhcss..ss.............ppp.t..h......p.......s..p..t..s...h...h...lpsLp.....P.....t.o..s..YClpVps.......t.s+pu.h....Sp.pChp..........................................	0	14	34	115
+9127	PF09295	ChAPs		ChAPs (Chs5p-Arf1p-binding proteins)	Mistry J, Wood V	anon	Pfam-B_11349 (release 19.0)	Family	ChAPs (Chs5p-Arf1p-binding proteins) are required for the export of specialised cargo from the Golgi.\	 They physically interact with Chs3, Chs5 and the small GTPase Arf1, and they form also interactions with each other [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.29	0.70	-5.70	14	327	2012-10-11 20:01:01	2006-08-24 15:27:08	5	42	208	0	196	576	86	276.20	23	43.34	CHANGED	psclGoaaYssGlDsSssASlAsaLpsLs.pl.pcsQhWFGcppsaKlsphoYCsaNAFo+sDhRVpV+IPGuV-oahlDpcG-+......cpt.................s-plWtETalSullRulhhu-D.......................ssssphpplstsRphNPhoss-h-cc.......FlcshEpLFhcGhpLGussclts..PThlsNaLVcullchh+hTppacpulsll-+Lpppp.PEVssLlA+lhlhtDcElcAV+lhpcuL........pps.pD.......ssLLslQucFLlsKc+s...........chALpsAppAVpuuPSEFtTWshLsclYlcLpDhENALLoLNSCPM...oapEK.hh+hssPhc.......lHLPlPh-ssL-Elsshsssc.....ppcpsDPsLlpLsAusL+uTFtpAYpLLTEIVpphGW-pLLKhRSpVFVMEEEYR	.........................................................................................................................................................t..........................................................................................hs.shs..htp.-hph....h.......t......p.................h...t.tt..................................................hW.Eh.hsthlR.h....p................................h....t..........................hh......h..h..h.......................u...............t...............................................s..h..........p....N.hL..ht..sh......h...hh...t....s.....p...h..t.....sh....phhc...p.........l..h..p...p......p....s....p.....s..............h....l....sp...l...h...h.............t...p..p...E...h......pu..lph...hpp.hl................pp..........s.................t.hL...hQu...pahhpp.tc.......................chAlph..uppusphsPspapsWhh.LsphYh.thpph-pA..L....h....s...l.N.u....hPh...........pp.p..........................................................................................................................................................................................................................................	2	63	120	174
+9128	PF09296	NUDIX-like		NADH pyrophosphatase-like rudimentary NUDIX domain	Sammut SJ, Bateman A	anon	pdb_1vk6	Domain	The N-terminal domain in NADH pyrophosphatase, which has a rudiment Nudix fold according to SCOP.	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.44	0.72	-3.65	75	1383	2012-10-02 00:00:35	2006-08-24 15:37:11	6	14	1293	3	430	990	338	99.50	22	32.64	CHANGED	puhhhlhpssplllps.......................................ththsththtth...........................shshtpslhLG...hhps........................pshaulshsttss.........................shphhsLRphh......htls.spphslhupAtpllpW	...........................................................................................t.shhll.pc.pplhlsp.......................................................s.tls.h.s.pstph.............................................shssp.pslh..lG.........phpu......................................psla.slphsttts.........................................................h.h..ssl.Rplh...................pls..ss.htlhupAhpLhpW.............................	0	106	236	334
+9129	PF09297	zf-NADH-PPase		NADH pyrophosphatase zinc ribbon domain	Sammut SJ, Bateman A	anon	pdb_1vk6	Domain	This domain is found in between two duplicated NUDIX domains. It has a zinc ribbon structure.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.69	0.72	-4.43	63	1999	2012-10-03 10:42:43	2006-08-24 16:14:14	6	20	1879	3	487	1363	306	31.80	34	10.88	CHANGED	psapFCupCGstsphtps.thuphC..ssCstpta	.....sa+FCutCGptht.sps..t..huhhC....spCtpchY........	0	120	265	382
+9130	PF09298	FAA_hydrolase_N	DUF1969;	Fumarylacetoacetase N-terminal	Sammut SJ, Eberhardt R	anon	pdb_1hyo	Domain	The N-terminal domain of fumarylacetoacetate hydrolase is functionally uncharacterised, and adopts a structure consisting of an SH3-like barrel [1].	25.00	25.00	25.00	26.60	22.30	24.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.32	0.72	-4.05	94	764	2009-09-11 16:58:44	2006-08-25 09:49:03	6	9	631	10	393	776	109	99.60	35	23.95	CHANGED	QNLPaGlFo.pss.ss....RsGVAIGDpllDLuul.ttt..................G.lhs......ts.tsshspssLNsFhuLGtssWpslRtpLppLLp.................thpsppshhptsLlstuc.sph+LP	.............................pNLPaGlFS.sss..ss.........RsGVAIGDpllDLuul.ttt...................u.lhs............t..tssFs..psoLNsFhuLG+ss..WptlRtpLppLLs.........................hpsspshtppsLls.sc..sphHLP........................................	0	104	219	322
+9131	PF09299	Mu-transpos_C		Mu transposase, C-terminal	Sammut SJ	anon	pdb_1bco	Domain	Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology [1].	20.50	20.50	20.50	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.03	0.72	-4.09	36	1172	2009-01-15 18:05:59	2006-08-25 10:46:00	6	26	862	3	233	975	33	64.70	26	11.47	CHANGED	Lclhhh....stptRpVp+........sG.lphh...sh+Yhsst.Ltua..sGcp...VhlRYDPpDl.splhVapp..sG......alspA	...............................hhh.....ttpRp.lp+........sG..lphp.............sh.p.Y......h.s......st....L.t.sh..........hucp...........VhlRaDPp..Dh..splhVhp...st.....hh...............................	0	68	146	204
+9132	PF09300	Tecti-min-caps		Tectiviridae, minor capsid	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	Members of this family form the minor capsid protein of various Tectiviridae [1].	25.00	25.00	197.80	197.70	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.96	0.72	-4.20	3	7	2009-01-15 18:05:59	2006-08-25 14:36:31	5	1	6	1	0	4	0	84.00	98	100.00	CHANGED	MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRAVAEQTYYAIGTGIQMGQTFNQPLINTQEG	MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRtVAEQTYaAIGTGIQMGQTFNQPLINTQEG	0	0	0	0
+9133	PF09301	DUF1970		Domain of unknown function (DUF1970)	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	Members of this family consist of various uncharacterised viral hypothetical proteins.	22.50	22.50	24.70	266.90	20.40	17.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.60	0.71	-4.05	3	7	2009-01-15 18:05:59	2006-08-25 14:42:11	5	1	6	1	0	5	0	117.00	96	100.00	CHANGED	MDKKKLLYWVGGGLVLILIWLWFRNRPAAQVASNWEGPPYMTYNQPQAGSVTLPVAGYTSPSLTLPNRNRSCGCNPAVSAAMAQGADLASKLTDSITSQLNNYAESLNDYLASQAGV	MDKKKLLYWVGGGLVLILIWLWFRNRPAAQVASNWEGPPYMTYNQPQAGSVTLPVAGYTSPSLTLPNRNRSCGCNPAVSAAMAQGADLASKLT-SIoSQLNNYAESLNDYLASQAGV	0	0	0	0
+9134	PF09302	XLF		XLF (XRCC4-like factor)	Mistry J, Wood V, Hentges P, Doherty A	anon	manual	Family	XLF (also called Cernunnos) interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining.  It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated downregulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining [1].  This family contains Nej1 (non-homologous end-joining factor) [2], and Lif1 [3].	21.70	21.70	22.80	21.70	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.64	0.71	-4.48	30	240	2009-09-11 09:52:26	2006-08-25 15:05:44	6	5	179	28	128	239	0	164.00	22	41.85	CHANGED	tsWphlplsp..s.........hlhpsphs..tsoas....lhloD........Lps..lWsEclspsslhp+upppstslcs...sspphphhLpclhpsh.......sspcssphsLppt.t.....tssLhlphphclsssh.shpWsh+lpppsss....slhppLshPLlphptshpppt..............................ppLtshLpcKDt...................................slspLh-phps	..................................Wthl.lst.ps.........hlhphhhs..ppu....t....lhlo-........Ltp..lWpEplspss....l.pcspp.spplss...s.sph.hhhLpplhpsh........sspcssphslsttt....................sssLh.lp..hpspLs..sh...shp.Wshclppssss....tlhp...cLhhPLhphttthppph..............................ppLtslLppKDt...................................tlpch.-pht.t............................................................	0	24	53	96
+9135	PF09303	KcnmB2_inactiv		KCNMB2, ball and chain domain	Mistry J, Sammut SJ	anon	pdb_1jo6	Domain	Members of this family are found in the cytoplasmic N-terminus of KCNMB2, the beta-2 subunit of large conductance calcium and voltage-activated potassium channels. They are responsible for the fast inactivation of these channels [1].	25.00	25.00	25.30	25.00	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.13	0.72	-4.18	7	63	2009-01-15 18:05:59	2006-08-29 09:22:20	5	2	35	1	25	55	0	29.60	80	15.20	CHANGED	MFIWTSGRTSSSYRpDEKRNIYQKIRDHDLLD	........MFIWTSGR.TSSSYRHDEKRNIYQKIRDHDLLD.....	0	1	3	9
+9136	PF09304	Cortex-I_coil		Cortexillin I, coiled coil	Mistry J, Sammut SJ	anon	pdb_1d7m	Domain	Members of this family are predominantly found in the actin-bundling protein Cortexillin I from Dictyostelium discoideum. They adopt a structure consisting of an 18-heptad-repeat alpha-helical coiled-coil, and are a prerequisite for the assembly of Cortexillin I [1].	23.90	23.90	24.00	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.53	0.72	-4.00	4	18	2009-01-15 18:05:59	2006-08-29 09:39:01	5	6	11	2	12	18	0	102.60	35	23.56	CHANGED	KEEKtcLEAS+s-hAN+LAuLEpSLEuEKsSp-pL....hKQKDp...LcuhLtoLcupsApRppRlpELpAKl-EhL+NLEhEKhA+hELEuRLuKsEKDKAILELKLAEAhD	..........+EE+ttL-uSpsplts+LAuLppSLEspKtSp-cL.......h+QK-p...LcstLppLcspssspspRls-LpA+ls-sl+sL-p.EKhA+.-LcsRLsKscKD+AhLEL+LtEh.s.........	0	9	11	11
+9137	PF09305	TACI-CRD2		TACI, cysteine-rich domain	Mistry J, Sammut SJ	anon	pdb_1xut	Domain	Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF [1].	21.30	21.30	21.40	21.50	19.00	20.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.11	0.72	-4.16	2	66	2009-01-15 18:05:59	2006-08-29 10:41:35	5	3	27	5	27	55	0	39.30	55	22.37	CHANGED	lsCRKEQG+aYDHLLtsClSCsShCsQHPpQCAaFCEp+.R	............sCp+EQGpYYDpLL+sClSCtSICG.Q.HP+.Q.CAhFCctp......	0	2	2	6
+9138	PF09306	Phage-scaffold		Bacteriophage, scaffolding protein	Mistry J, Sammut SJ	anon	pdb_1gp8	Domain	Members of this family of scaffolding proteins are produced by various bacteriophages [1].	25.00	25.00	25.30	25.80	24.00	24.90	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.88	0.70	-5.27	2	104	2009-01-15 18:05:59	2006-08-29 10:52:09	5	1	99	2	5	48	0	273.20	52	92.96	CHANGED	M-.TT-IQuoE-LTLoGsHAAASADuLVVDNANDNAGQEEGFEIVLK.DE.tPKQDPApNAEFARRRIERKRQRELEQQMEAVKRGELPEpLRVNP-LP.QPD.NsYLSE-uLAKYDYDpSRALAAFptANoEW.hKA.DARSpAVAEQGRKTQEFTQpSAQYVEAARKHYDAAEKLNIPDYQEKEDAFMQLVPPAVGADIMRLFPEKSAALMYHLGANPEKsRQLLAMDGQSALIELTRLSERLTLKPRuK.lSpAP.sDpPIpGcssAANhsAIcKQM-AAAsKGDVETYRKLKApL.KGIR	..................................................................................................................................................................................EpQhEsh.c.RtpL.EuLts.pPs..pQPpssAh..scssLtphDYDpp....AFppA.T-W.p.Kttcsc....pQt.tpptRpp.QEapQp.tQhVEAhtcHhpt.AtKLsl.DYQEhEshhhp.lPPh.tt.Ih.+hh..sEtSthLhYtLGtN.tphRQllA..h.Ds.pAhh.LsplSc+loLtP+sKps..ss.s...h.tts...................................................................	0	2	2	2
+9139	PF09307	MHC2-interact		CLIP, MHC2 interacting	Mistry J, Sammut SJ	anon	pdb_1muj	Domain	Members of this family are found in class II invariant chain-associated peptide (CLIP), and are required for association with class II major histocompatibility complex (MHC) in the MHC class II processing pathway [1].	21.00	21.00	21.10	23.40	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.53	0.71	-4.30	11	121	2010-01-11 15:07:59	2006-08-29 13:06:26	5	6	60	11	32	96	0	111.30	39	44.98	CHANGED	M--QR.....D..LI.ossppshLPh....sssscuusoRuhtloGlolLssLLLAGQAlTsYaVapQpGcIscLTpTspsLphE.LppKhPtu..ssspM+hsM.shPhLhchhs.sss..tss...hc	.....................--Qp.....D..LI.usp...pp...L.sh........sss.cupsoRushhoGhSlLVsLLlAGQAsTAYFlYQQpGplcKLThTSpsLpLEsLph.......Kh.Ptss.sss+M+Msh....Phlhphhs.t.t...hs..t..............................	0	2	7	15
+9140	PF09308	LuxQ-periplasm		LuxQ, periplasmic	Mistry J, Sammut SJ	anon	pdb_1zhh	Domain	Members of this family constitute the periplasmic sensor domain of the prokaryotic protein LuxQ, and assume a structure consisting of two tandem Per/ARNT/Simple-minded (PAS) folds [1].	25.70	25.70	26.10	35.40	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.50	0.70	-5.03	6	115	2009-01-15 18:05:59	2006-08-29 13:44:49	5	8	113	6	14	78	0	236.20	54	28.02	CHANGED	SspIItQEVpRTpQQTSuLIpNlF-p+LuhLQIHpDSsuKstulhchah-pD.s-pLshFFhSlDQt-PopTP-FRFlospcullWDDGNApFYGlNp.hLcplup+VshSNNWaalpsposhG.tahLlRRoPll-ssTGEVlGahYsuVVLsNNFuLhEpL+stSNS-NlVllssspsLASSLsGs.EsY.slssVLppppssp+hDshllscTPIplpussT.lslLolQsNpsVloL	...............SS+lhuQEspRTshQTSSLIQsLFDFRLAALcIH.QD....SoAKNsSLlsALsoRD.sspLDpFFsSVDplEhSNAPDlRFISoHD.sIlWDDGNApFYGIspp..pLs+Lh++VuhSuNWHlVQTPSphpshHlLhRRoulI-ssTGpVlGYLYVGIVLNsNFALlEsI+sGSNS-NlVLsVcosPLsSTLKGN..EP.Y..o.lc.Vl...........+s.uc-sh+.D.ualVuQThLEVcuVPTaLCVYSIQsNQNVlTL............................................	0	5	6	11
+9141	PF09309	FCP1_C		FCP1, C-terminal	Mistry J, Sammut SJ	anon	pdb_1onv	Domain	The C-terminal domain of FCP-1 is required for interaction with the carboxy terminal domain of RAP74. Interaction relies extensively on van der Waals contacts between hydrophobic residues situated within alpha-helices in both domains [1].	22.70	22.70	24.10	24.40	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.96	0.70	-5.08	4	63	2009-09-11 10:47:49	2006-08-29 15:20:43	5	6	42	2	32	66	0	210.90	56	26.15	CHANGED	ERW-KVEEQLFPL+DDaoKspRsNSPAsFPDppush.TsLFHPsPI+sKs.pPGPEVRlYDssTGKLIRpGsQuStPuP......sSuhss+tEPSSFRuVpPpQ.QhFs..EphssuQDsEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSD.DSDuEKK+s..p.c-pEptsQspK.psPs.RpEp.................s.thPuSSERSssGuRsPRGHKRKLsEE.........DAtSE....pStESSNEDEtGSSSEADEMAAALEAELNDhM	........................................ERW-KVEEQLFPL+-DasKs.p.RpsSPAsFPDppush.TsLFHPsPlpPKs..pPGPEVRlYDssTGKLIRpGs....psst.ss.........s..s.Lsl+tE...S.SFRsVpPpQ.pQhFs....EphssupD...s.EQPGPSR..RKRQPS...MSETM.PL.YTLCKEDLESMDKEVDDILGEsSD.-S-ucc+cs....p.cpct..t.pspp........s.t.pptp...................t.sssupcs.hss.p..sR.GHKRKhp-p..........-htsp.............pStcsSN--E.GSSSEADEMAtALEAELsDhh................................	0	5	8	16
+9142	PF09310	PD-C2-AF1		POU domain, class 2, associating factor 1	Mistry J, Sammut SJ	anon	pdb_1cqt	Domain	Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres [1].	19.20	19.20	19.40	19.20	18.40	18.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.89	0.70	-5.22	2	69	2009-01-15 18:05:59	2006-08-29 15:42:10	5	5	43	2	30	56	0	197.40	55	86.37	CHANGED	MHhtKS.hSEQtsp.+PYQGVRVK-PVKELL+RKRGNs..ApshssTsVVlPppsLPSYo.hG.ssh.ssstuA.s.sus-.GALCsuWluQPSs.uohQPLspWss.P-YhpHEt..uohP.hTuDMYlQPhCPSYslVGPSSVLThAptPLhTNhsshS.STsul.PQl-V..QpssLsYhPWA.PLSshPtss...........sPQhlPhPlslscPtPQp.EsA.ps.GTLslEKLL.E-E-spp..Yshs.uL.spsl	................sEQt.P.s.P.RPYQGVRVKEPVKELLRRKR.....G.+.s.....ssG..s..sssPT.u.V....V..LP.+pPLso.Yos...s.....Gsssl.-h-s.us.ss...s--us.LCsu.....W.luQPss..AsLQ..PLs..s.Woshs-Yh.c-u.......sosP.houDhYl.QPh.CPSYT.hVGsoShLTYus.PL..lTNhssp..............S..usPs..ssP.lEh.-pQuPLTYhPWsQPL...STLPss..oLQYQssussLPGPQFVpLPISIP......EPs.Q-h-DsRR.shsoLsI-KLLLE-E-sss..Y.hspsLslEG.h...............................................	2	1	3	11
+9143	PF09311	Rab5-bind		Rabaptin-like protein	Mistry J, Sammut SJ	anon	pdb_1tu3	Family	Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes [1].	26.00	26.00	26.00	26.00	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.12	0.71	-4.39	20	544	2012-10-11 20:01:01	2006-08-30 09:24:06	6	90	98	14	254	485	0	165.40	42	29.53	CHANGED	ELuhucuQshhslpppLstlpsp+p+lcspl+RLspENpaLRsEhutoppch..ptpEppstpL.-chccLpahsphp+.Dthpppst....cpchcschssLcp.......hhss.E-phtsph..................p.tsptsstpssthEhsucLRoL+sLllQhssQs+hE........htlshsKpALEDLppsstccpscl	........................................ELuhu-uQlhhuLss+.Lssl-uE+Q+L+s.......QVRR.LsQ.......ENpWLR-E....L..u...s..TQp+L........QpSEppVAQLEE....EpcHLcFh..spl++hD.tsts..s........t..............-.c.....c...t....c.s.p.p.-sLc-..................Lhss-E--.stth...................................................t.tsttustp.puuhElPARL.RTL+NLVIQYuuQ....GRYE...........................VAVPhCKQ..ALEDLp+osG+cHscl...................................................................................	0	51	71	148
+9144	PF09312	SurA_N		SurA N-terminal domain	Sammut SJ, Bateman A	anon	pdb_1m5y	Domain	This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	29.50	29.50	29.50	29.50	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.25	0.71	-4.24	19	1802	2012-10-02 13:36:56	2006-08-30 10:53:39	6	12	1787	8	392	1588	590	113.80	32	28.46	CHANGED	lD+lVAVVN-sVlLpS-L-ptlcpVcpphtppsspLPPcsVLccQVLERLIl-plQlQhAccsGlRlsDspLspAlusIAppNshol-QhppuLup-GloYspaREQIRcEhlluclR	..............................................lDplsAl..VNssllhpo-l....cth....h....p......p....l..ph...p...h.....t....p........t........t.....t.....p...l........P....s......p......s.....t....L.....+....c.......Q..l.......L....-+LIh-pl..lQ......hu.p+.hG.l..c..l..s....DppLD.p...AI....s....s...I.......A....p.......p......N....s...h...T....l......-..Q..h.+..spL....s.t.c.G.l..sa.s....pa....Rpp....lRc....-hhhsclp.........................................	0	109	231	319
+9145	PF09313	DUF1971		Domain of unknown function (DUF1971)	Sammut SJ	anon	Pfam-B_3000 (release 20.0)	Domain	Members of this family of functionally uncharacterised domains are predominantly found in bacterial Tellurite resistance protein.	23.10	23.10	23.60	23.60	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.70	0.72	-4.26	44	1196	2012-10-10 13:59:34	2006-08-30 14:03:34	6	10	1013	13	105	527	12	81.20	43	43.97	CHANGED	KphPlascsolPphhhpcH...NTKsGsauplsVlpGpL+ahths-ptt...spclhhssspsshstPphWH+VEsho-Dhchplc	......+phPhWsKpThPtulhp+H...sT+sGsas+LoVhcGslKahshs-.....Ets.pssphlhhsuuphsh.hsPptWHplEshTDDspapl-.........	0	10	37	74
+9146	PF09314	DUF1972		Domain of unknown function (DUF1972)	Sammut SJ	anon	Pfam-B_3020 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in bacterial glycosyltransferases and rhamnosyltransferases.	21.10	21.10	24.00	23.10	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.20	0.71	-4.83	12	494	2012-10-03 16:42:30	2006-08-30 14:34:02	6	7	403	0	103	539	148	177.60	41	47.78	CHANGED	hpcVaIIGS+GlPA+YGGFETFVEcLlcaQpsp.sIpYaVAChu-sptpp.....pFcYpGADCFsIssPplGsA+sIhYDhhAIphAlchsKppp.ppPIFYILGsoIGsFIs.at+pI+plGGplalNPDGlEW+RuKWutPVppYLKaSEKlMsKaADLlIsDNpsIEpYIpscYs...scTpaIAYGTD	....................................................................................................ppVaIIGo+GlPApYGGFE....TFVEcLs.p..h...p.p..s............p...sI.p........YaV.uCh.......s.c...s....p.s.t.p..........................phca.pGs.csas..l..s..s.P..p...l...G.s...A.c...sIsYD.hh...AlphAlph.h+pp.t....pts.I.hY....lLuss..lGs.Fl.h.shh+pI+phGsp.l.hlNPDGhEWcR.u.KWut.sV.+pYh...........KhSEphMsKaADllIsDspsIcpYlppcYs...........scTsaIAYGsD......................	0	25	61	79
+9147	PF09315	DUF1973		Domain of unknown function (DUF1973)	Sammut SJ	anon	Pfam-B_3022 (release 20.0)	Family	Members of his family of functionally uncharacterised domains are found in various eukaryotic calcium-dependent chloride channels.	21.00	21.00	21.60	21.50	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.18	0.71	-4.84	13	287	2012-10-03 16:25:20	2006-08-30 14:51:31	6	17	61	0	185	287	1	171.20	37	20.05	CHANGED	ulQLESpG...slpsschlsGTVsVDSTVGsDThFLlTWssp..sPpIh...LtDPsG+pYso..FhsD.tss+sApLpIPGT.AcsGsWTYoL.ptpsssQsLTlTVTSRAuSsolPPlslsA+hspcoupaPSPhlVYAcVpQGhLPlLuAsVTAhI............EopsG+sV..TLcLLDNGAG.ADssKNDGIYSR	................................................................................lQl.Sps....plpspthhssoVhlDuoVGp-ThFllT.Wssp..............P.p..Ih.....LhDP.sGphhss..............Ft.hD....hs...+hutLp.I.P...G.....s...Ac...sGtWsYol............pt......p...ss..s...ps......l....ol.........TVT..SR..As......s.s........s.s......s......Pl.o.....Vsu...th...s...p...ss...sp....a.....P...s...P....h.l..lYApVpQGh..hPlLu..AsVTA.hI..............E.spsGp.s.s.....sLcL.hDNG.A....G..A....DshKsDGlYSR......................	0	86	92	118
+9148	PF09316	Cmyb_C		C-myb, C-terminal	Sammut SJ	anon	Pfam-B_3027 (release 20.0)	Family	Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis [1].	20.30	20.30	20.90	20.90	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.38	0.71	-4.58	15	288	2009-01-15 18:05:59	2006-08-31 09:38:54	5	26	77	0	111	268	0	154.40	46	24.59	CHANGED	FSPSQFLNtsspp-shsl-sssLTSTPVC.uQKsh.oTsLpRDpTP.hhQKENuhFRTPsl+RSll-sTPRTPTPFKsALsh.-cKYGPLKhlspTP.aLEEDlpEVl+pEsspslIlt-psc...PhhKK...tKQ.phcSP..hKKVRKSLsLchh-.pch..ssphhspsss.scptPs	...........................................................FSPSQFL.Nssssp.-phsl..EsPoLTSTPls.upKlhlTTP....hH+-p.Ts.+....sQKEN....ss.......FRTP.s...h+RS.l..lp.soPRTPTPFKsALAsQEtKYGPLK...h.l..P...QoPuaL.EDlpEVlKpEospsh....hl.t..-.pc....................P.h++.........hKQ.phpoP..scKstp.hs..ctW-t-ph...ssphhsps.s.......p........................................................................	0	15	23	54
+9149	PF09317	DUF1974		Domain of unknown function (DUF1974)	Sammut SJ	anon	Pfam-B_3029 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are predominantly found in various prokaryotic acyl-coenzyme a dehydrogenases. 	25.00	25.00	28.20	26.30	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.80	0.70	-5.00	103	1236	2009-01-15 18:05:59	2006-08-31 10:02:30	6	6	996	0	224	886	173	278.60	50	35.24	CHANGED	lRCHPYlLcEhpAutssDp.ppuLcpFDchlhuHlGashsNshRuhhhuLTuuphu.suP.....ssstoppYY+plsRhSAuhAlhuDluMhsLGGsLKR+EhlSARLGDlLSpLYLuSAsLKRa-Dc...GR.ppDlPhl+auhpcsLhphppAhcchlpNFP.s+hluhlLRhl.lFPhGp.p..hptPSDcLspclAchlh...pPus..sRcRLspsh.Ylsp......s......csss.lGtlEpAapshhps-slhcKlpcAh+...tsplshh......phpphhptAlctGlIopsEschLpcscthRhcsIpVD-F	.................................IRCHPYVLcEMpAApss..D.....lpsFDclLFpHIGassSNtlRShWLGLTtGhho..ssP.......ssssT+RYYppLNRlSAsLALLuDlSMulLGGuLKRRERlSARLGDlLSpLYLASAs.LKRY-DE....GRpc.uDLPLVHWulQDuLapAEpAhD-lLpNFP...NR.sl.uulL+sl...lF.P.hG...R...+...ahuPSD+L-cclAclLQ...sPsu..oRsRls+Gp.Ylss.....u..............-csP.VGhlEpALhslluA-Plap+lsKtlt.pplPhp.........pL-clscpALtpGlIsp-EAslLhcAEctRh+uIsVDDF...............................................................	0	52	102	172
+9150	PF09318	DUF1975		Domain of unknown function (DUF1975)	Sammut SJ	anon	Pfam-B_3057 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are predominantly found in the N-terminal region of various prokaryotic alpha-glucosyltransferases.	26.80	26.80	26.90	27.10	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.43	0.71	-4.71	51	2040	2009-01-15 18:05:59	2006-08-31 10:17:07	5	3	483	0	135	1104	1	188.20	20	38.94	CHANGED	hhYhlspslshssSGlEhAthtRhplFcp.hshssKhlhhsap..splpphhcphsh.....pc.scllshY-aFpch...hsssptt.hsh...cplsh.pthphttss..thhphh............ps.phhhtlhhtspp...phlppl-ahs.pspl.l++-hashpGahSphthast.ssclhhcpaas.-Gphhhcchh.tspptt.phs...h.........hhFps	...............................................a.h...l..t.ss...s.h.ph.placp.hsh....sschlhhs...at......plp.p.h.hpphsh...............hs.schhsh.Y..s..aFpsh.....ht.pptt.hsh..........pplsh........t...t.hchhtss......p.hc.lhs....................ps....phh....s.ph.aaps.p..t......phlphl-aac..p..spl.h++-.hYstpGhhSshph.....hss..p.....s......c......hhh....cpaas.pGphhlpchh...s..sptt...h.....hhh..tt.........................................................	0	43	57	115
+9152	PF09320	DUF1977		Domain of unknown function (DUF1977)	Sammut SJ	anon	Pfam-B_3043 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are predominantly found in dnaj-like proteins.	20.90	20.90	20.90	21.10	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.42	0.72	-3.80	29	448	2009-01-15 18:05:59	2006-08-31 10:32:53	6	9	265	0	284	412	2	105.10	31	28.52	CHANGED	lluphhss........sPs.YSh..p.o.tashpRpTsphpVsYYVsp..sFppca.....susplppLEppVEp-YlppL+psChpEppp+..........................pphh.tAp..hhtDpc..hhpcApphphP.sCccLpcl	......................loplhso........sPs..YSL........pso..ssa..s.hcR...pT.p.......p..l..p....V....sYYVsp..sFp.pcY..................puspLppl.EcpVEcDYlspL+psCh+Eppp+..........................pphh.tAp.....hatDtc....hhpcApphths...sCpcLpp..............................................	0	78	129	206
+9153	PF09321	DUF1978		Domain of unknown function (DUF1978)	Sammut SJ	anon	Pfam-B_3044 (release 20.0)	Family	Members of this family are found in various hypothetical proteins produced by the bacterium Chlamydia pneumoniae. Their exact function has not, as yet, been identified.	25.10	25.10	25.20	63.70	23.20	25.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.69	0.70	-4.93	6	49	2009-09-14 14:09:44	2006-08-31 10:41:27	5	4	2	0	25	49	0	196.80	38	35.96	CHANGED	cDcpKsupAcpcatEht-phcca+KshFWLsE-ssIDh...ossssWshst.PpRps..........hsclspcEh...Wp+pstLK+hcspYspshsphpcpsoccNpptLp-tppch.cthp-happEhccscpRlcsLpthYspl.sspp-sctppphs..h.......cL-phh-pIEpphppssc-Q-sYWKpp-s+E....tEh+Ectsctcp.cEhpcsLct......L-chl+pppcpLchlctclpctphphst.sspppLpsu	.......cDcsKSupAEp+hp-hp-pWcca+cslFWVcE-GshDl....shh.usWshsh.PhRpt.........RhsclshHEl...a-cThhlKch.cpphshA+sthEKptSpcN.pthpchptth.p.hpchhtpEhpcstpRlcpLpthYstl.sp..-tchppph...........sL-phhttl-pphppssp-Q-.Yhc..-.pE.....Ehctphsphh..cph.p.hp.......h-phlcth.ppL..hph.h.tht..hpt..t.h.lp.........	0	0	0	25
+9154	PF09322	DUF1979		Domain of unknown function (DUF1979)	Sammut SJ	anon	Pfam-B_3053 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in various Oryza sativa mutator-like transposases.	25.00	25.00	32.20	31.70	21.40	16.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.80	0.72	-4.33	3	157	2009-01-15 18:05:59	2006-08-31 10:53:18	5	17	4	0	87	153	0	57.80	75	4.81	CHANGED	MSSKlhFchaaGEGNVRaGPsGVDLSDFlsooRGIDRPAERSFpSIpNWLMRGFRIDP	....MSsKlhFQlhHGpGNlRaGPsGVDLSDFlhTu+GIDRPAERohpSIhuWLhRGhRlD..................	0	0	0	2
+9155	PF09323	DUF1980		Domain of unknown function (DUF1980)	Sammut SJ	anon	Pfam-B_3062 (release 20.0)	Family	Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined.	25.60	25.60	25.60	25.90	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.99	0.71	-4.54	29	841	2009-01-15 18:05:59	2006-08-31 11:00:14	5	1	748	0	102	467	0	173.80	37	63.92	CHANGED	hlRhLILhGashlhhaLhloGclspaIss+ashhshhuhllhhILullQlhhhhpshcpp..................cpH..t....t+hhshhlhllPllhGhh....hPssoLD......SshsstKGhphsh........ts....tscptopsphl+s-..............stt.htp.hpt.h.pphhtpppIpls--sahcsh-tI..hp.s.scahG+	..............MlRhllLhGah.LhhaL.plSGcLspYINh+YsYLuhlohll.hlLA...l..VQlh....l....hh+...phc.p.............................HsHh.ps+........t+hhuhsLLslPlllGlh...........FPoloLD..................................Ssh.V...sAKGapFPl..........................utts....ps.s..tts..p..sQaL+PD.............................TS.Ya.scs....sYcctM.ppth.cca..hsp..ssIplssENYhcsMEhI.YsYP.s-FtGK........................................	0	30	70	85
+9156	PF09324	DUF1981		Domain of unknown function (DUF1981)	Sammut SJ	anon	Pfam-B_3041 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in various plant and yeast protein transport proteins.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.71	0.72	-4.46	41	681	2009-01-15 18:05:59	2006-08-31 11:31:41	5	13	272	0	470	659	6	83.80	34	4.95	CHANGED	h+FLcp-ELspap.FQ+-FLpPFEhlh.....pps..psh-l+-hlLpCltphlps+s..spl+SGW+slFsllshuuppps-pllphuap....llph.l	...............................+Fh-ctELspFp.FQc-FL+P..FEplh......pps..pssslR-h...llcCltQh..lpupu..ssI.+SG.W+slF...uVhptAus...-....p....p.csllphAFppht...................................................	1	163	245	367
+9157	PF09325	Vps5		Vps5 C terminal like	Mistry J, Wood V	anon	Pfam-B_6206 (release 20.0)	Domain	Vps5 is a sorting nexin that functions in membrane trafficking. This is the C terminal dimerisation domain [1].	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.27	0.70	-5.11	22	1147	2012-10-03 12:17:00	2006-08-31 11:48:15	5	17	292	0	720	1151	2	193.30	20	42.46	CHANGED	htphhsshtpulst........shKhsEs.....DpaF.-+pphl-sLEppL+pLhcul-slsspRp-Lutshs-hupulstLussE.s..psLSpsLspLu-lpt+lcphhpcputpDhhpLuthlc-YlRhluSlKssFspRhKhapphppsppsLpKK+pphsKhpts.tsp..t-KhpphppElp-hcp+sppscpcFccloppl+cElp.+F-p-+hcDFKsslptaLEutlcsQcEhl-hWEsFhsp	..................................................................................h........................th..p-.............D.hF.p........tt.h.ph.cpplp.p.h.pttsc.ph.spp..+.c.......plutshs..phutshtt.Lu......t.....E...t.p................s..l.......s..p........s.......h.......pplu.......c.h.p.......ph..pp......h......t........p.c.....u.....ps.-.hph........sch...lp.Yhp.ht.......ul+sh.hppR.pth..php.pspptLpct...+tt..t.....ch....................................h.......t.....................................................p...............c...+hp.p....h..................t....cl.t.p..............hp.....tp.p..thp.......pphcpl.s.......p....h...pp..Eh..cap....pp+htsh+p.lhphhp..lphtpp....ht............................................	0	198	345	556
+9158	PF09326	DUF1982		Domain of unknown function (DUF1982)	Sammut SJ	anon	Pfam-B_3077 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in the C-terminal region of various prokaryotic NADH dehydrogenases.	25.00	25.00	28.00	26.70	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.70	0.72	-3.81	98	630	2009-01-15 18:05:59	2006-08-31 12:44:19	6	11	567	0	299	594	813	49.80	34	7.25	CHANGED	Dpltssshts.hsh.h..........splup..ss.F...psslpDFYhTsPIuRASssMAcC	.............................Dpltsss.htp.hss...............hssphss..ss.h......ptslcDFYhT.ssIoRASssMAcC..	0	96	171	232
+9159	PF09327	DUF1983		Domain of unknown function (DUF1983)	Sammut SJ	anon	Pfam-B_3073 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in various bacteriophage host specificity proteins.	20.90	20.90	20.90	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.64	0.72	-4.03	47	1596	2009-01-15 18:05:59	2006-08-31 12:57:54	6	28	644	0	69	1683	37	78.60	46	8.51	CHANGED	lpptupuhsshsG....clsAhaslKsps.sssGphhsAGhuluh-.sssusspSpllltADRFull...ss..ssGshtsP......FVlp..sG..plal	.......................................................................lpphp+s.hDsNs.........phsAMWul.Klpp.spD.G..phY.l.A.GIGhuhE.sTss..s.........hhSQlLluADRIAhI....sP...ssGNp..pPh......FVuQ..GsQlFM............	0	7	22	45
+9160	PF09328	Phytochelatin_C	DUF1984; 	Domain of unknown function (DUF1984)	Sammut SJ, Bateman A	anon	Pfam-B_3070 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found at the C-terminus of plant phytochelatin synthases.	25.00	25.00	26.20	78.80	21.10	24.70	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.82	0.70	-4.90	14	95	2009-01-15 18:05:59	2006-08-31 13:15:16	5	3	42	0	22	104	0	238.20	45	54.33	CHANGED	p+sPulLYTLSC+cESWhuhAKYLhEDVPhLLpScslcslpclLSslhcSLPuNhspFIKWVAEVRRpE-Gs.psLScEEKpRLtlKpcVLpQVp-TcLF+hVschLpp.pt.stp.stsstcDSLs.plAAsVCCQGAslLsGp.hsussthCC+c.Tsh+slcus.GcsssTVlSGsVl..ssssEQuVDhLlPhs.tpssssss.........t.stp..hhHPossDVLTlLLLALPPpTWtsIcDcpLhsElpsLVSp-sLPslLQcEV.LHLR.cQL	...................+.sshLaTLSCKcpsWhuhuKYLhE-VPhLL+ScslssVccll.slhpSLPushspFIKWlsEVRhtE-Gs.ppLSpEEppRLtlKpcVLpQl+pTcLFphlscaLpp........s.ssp--SLs.phAApsCCQGAthLs..Gs..s.SsthCs+c.sshpslpus..ucu.ssVloGpVl..ssGsEQslDhLVPpp.sps.s.ssss.........t.s.p..shaPossDlLTVLLLALPPpTWpsIpDpplhtEhppLlSpcpLPs.LQpEV.hHLpcQ.......	0	3	14	17
+9161	PF09329	zf-primase		Primase zinc finger	Mistrj J, Wood V	anon	Pfam-B_9710 (release 20.0)	Domain	This zinc finger is found in yeast Mcm10 proteins and DnaG-type primases [1].	21.80	21.80	21.80	23.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.44	0.72	-4.36	37	283	2009-01-15 18:05:59	2006-08-31 13:27:25	6	12	258	4	201	287	3	46.00	37	6.37	CHANGED	GpupDhGhCpuh+.+sGphCsshlNt.....pcspaCpaHhphp....h++h.pupR	.....GpupDlGhCKuh+..KsGch...CsshVNh.......pcs-aCpaHlptp....h+Kh.putR...........	0	58	101	164
+9162	PF09330	Lact-deh-memb		D-lactate dehydrogenase, membrane binding	Sammut SJ	anon	pdb_1f0x	Domain	Members of this family are predominantly found in prokaryotic D-lactate dehydrogenase, forming the cap-membrane-binding domain, which consists of a large seven-stranded antiparallel beta-sheet flanked on both sides by alpha-helices. They allow for membrane association [1].	25.00	25.00	70.10	61.00	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.81	0.70	-5.03	19	896	2012-10-02 00:48:38	2006-08-31 13:47:55	6	2	874	2	110	550	214	277.90	68	51.68	CHANGED	VFYIGTNssscLTclRRclLssFcsLPluGEYhHRDhFDIA-KYGKDTFlhIcphGTcpLP+hFulKuplDshhp+lsalscaloD+lMQhhuclhPsHLPcRMp-aR-+YEHHLlLKMuscGlpEA+paLcpaFucus..GsaFECos-EGp+AaLHRFAAAGAAIRYcslHpscVEDIlALDIALRRNDc-WhEpLPtEIsspllcKLYYGHFhCHVFHQDYIlKKGsDsptlc+cMLcLLDpRGAcYPAEHNVGHLYcAcssLppFY+cLDPTNoFNPGIGKTSKpKpW	..................VFYIGTNpPpVLT-IRRHI.LusFcsLPVAGEYMHRDIYDIAEcYGKDTFLMIDKLGT.D+..hPhFFsLKGRsDAhL-KVpF.htsHFTDRsMQphu+LFPuHLP.RM+saRDKYEHHLlLKMuG.DG.......VuEA+paL............t-a..F............ppA.....-......Gs....FFsCTsEEGsK...AF.LHRFAA..AGAAIRY.pA.VHuDEV.EDILALDIALRRNDp-WaE+LPPEIDspLlHKLYYGHFMCaVFHQDYIVKKGVDs+A.............LKcpMLcLLppRGAQYPAEHNVGHLYcA.poLp+FYRc.DPTNShNPGIGKTSK+KpW..................	0	20	49	82
+9163	PF09331	DUF1985		Domain of unknown function (DUF1985)	Sammut SJ	anon	Pfam-B_3094 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in a set of Arabidopsis thaliana hypothetical proteins.	29.80	29.80	30.10	30.50	29.50	29.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.72	0.71	-4.38	50	173	2009-01-15 18:05:59	2006-08-31 14:19:20	6	13	9	0	34	177	0	119.50	24	17.19	CHANGED	LLsRpLhscKcpE.hWhlhuGpPlRFSlcEFtllTGLsCtphPpphcsppttph........shhpph....h...t.ppshsltclhphLppt.......hhsstp+lpluhlhhlsullhsppphst....lp..hhchsp-lchhhsaPWG+h.uFpt.hhpsl	.........................................hh.pph.hpp..p.hWhhhss.PlRaulpEathlTGL.Ct.hspp.p....th.th...........thhtph....h...h.pps.hshtcl.phL.tt.......thps.tp+lphuhlhllpullhsppptst....ls..hlchspslchhhpaPWGchuFphhhpt.....................................................................	0	12	13	13
+9164	PF09332	Mcm10		Mcm10 replication factor	Mistry J, Wood V	anon	manual	Domain	Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha [1].	20.10	20.10	20.40	22.10	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.59	0.70	-5.10	9	127	2009-01-15 18:05:59	2006-08-31 15:11:39	6	8	106	1	85	126	3	292.30	32	37.32	CHANGED	holPTsGhhplppc.....tpu.httsGsshpShSAspLLKpQ+ppp.phLthh+ccuEclQK+......hLpSostscssSpsooo.......pushpoPptus-h.pspth....ssoPKLuRuhs.u.Dl.Fhscpss...t.supu.pAtKhAAltKL+A....LtKtsPN.lK+Kpupouc.h.lsptVcpp.......ssuu.....ppus--pEPthKKcR......p.cEhp+ILsAKSpHosllcttEtEhQEcYFssL.+KEphEEKMpshhEhp.C+sVTCppCKYTtFpsu-cClpEpHch+hHDAsKRFF+Cs.CGNRTloLtRLPKppCusCsh.KWERsuMl+EKpG.plGGEsLhsRGEEc.KFLsS	.......................................................................................................................................t.....t......p.hss.th.tppp.p....h.h..h.ttp...ttthp........hhtsstt.........s........................s.ph.p....p...t............s.s..hPpLupu..t..u.pl.h.hs...tp............s.u.......K..hsAlh+h+s...........ltK.sPN.h...p.p+t..tpstc....t....lp.ptscpp................t..s............pcp.c.t.++p+.......................pp-ph...pcl...l..p.A+SpHssllcpsEt-hpEcYFp.L.+KEpMEEKMpshpEhp.C+sVpCcp..C..p.YTtFpss-pChpcpHs.l+.h+DulKRFF+Cs..tCGpR..ol.ol.p.+.l.Pp.p...pCps..Cs.......+.WERsuM..........h+...E.....+p......s..hhstEtL..RG-Ec.pFlsS....................................................	1	30	39	66
+9165	PF09333	ATG_C		ATG C terminal domain	Mistry J, Wood V	anon	Pfam-B_61662 (release 20.0)	Family	ATG2 (also known as Apg2) is a peripheral membrane protein.  It functions in both cytoplasm to vacuole targeting and autophagy [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.01	0.72	-3.84	36	689	2009-01-15 18:05:59	2006-09-01 09:08:59	6	33	269	0	463	699	7	95.20	27	4.20	CHANGED	+thSlYusQ...PtslppGlppAYpoLpc..............................slthstpslhpsstch..hc....spuspuA..........stsVl+tsPssllRPhIGuT-AlupsLhGlpNplDPppppc.c-KYK	..................................................................p...phhspp....Ptslt-Glspuhpultc..............................ulhsu...hsulhppPhcs....tc...........pcGssG..h..........................hpGVs+ulss.sls+PhhGss-hsSpshtGlcN.......ph..................................	0	164	244	364
+9166	PF09334	tRNA-synt_1g		tRNA synthetases class I (M)	Bateman A	anon	Pfam-B_107 (release 20.0)	Family	This family includes methionyl tRNA synthetases.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.33	0.70	-5.81	39	7775	2012-10-02 18:00:56	2006-09-01 16:59:03	6	66	5004	42	2168	33465	18847	310.30	30	47.26	CHANGED	hhlTosl.YsNussHlGHhh.ohlsADlhsRapRlp.Gp-.VhFlsGoDEHGp.IphpApcpGloPpchs-c.hpptapchacp.hsIsaDtFhRTTsppHpchspchapcLhcpGhIactphpthYsssscp..Fls-+.................upCP................tCG+plc.................hh+.pcpaFFcLscapct....................Lhcal.cps.t....psphpphs.sal..cpGLc-huIo...pchsW.GI.l.....P.....ssps+slYVWhDAhlsYloust.hs....................c.pa....pcaW.....p.....t.hHhIGKDIlhFHslaWPAhLhu..........tshp.......lPpplhupualsh-Gp.KhSKSpGsslps.pchlcp.as..sDhlRYaLhp.psshspDscFShcchhp+lNs-LssslGNhlsRsh	........................................................................................................................................................hlTsslsYss.G........t........l.Hl.GHhh..shltu.Dlhu.R.a.........p.R....h....p......G............h.........s..........V.....h..........a.........l...............s.........G..........s.................D........t..H.........G.............t...........................l......p..........t...............t.............A.................t............p..................t..................G......................h................s....................P.................p.................p.................h.....................s.................c.................c................h.................t................t.................p.................h............p............p........................h................p............t..............h................s..................l.................S............a...............D............p.............a.............h.........p....................T.............o....s......s......p......a..........t....c.h....s..p........t.........l.........a....................p...cL...h....c...p...G..............Ih...p.t.p.h.p.....t...h.a..s..s..p..p...p...p....a...h.s-p......................................l.t.t...h.................................................sut......h..p...........................................................................h..p.....p..cpaFhc..l..s..t.......h..t..p.h........................L..t.ah....p.......t.....t.................p....h.......ph....h....pa.h...............p.....s......L.p......t...hslo........ps..h........a.Gh...l.........P......................................tt.t+h..h..Y.V..........W........h......D........A...........h.....s.......Y...h..s.....sht..t...............................................................a.............pp.a...W.................................................................h.p.....h..h.......GK.........D......l...................h....F...........H...s....l...h....a....P...h..h.L.u..............................th..................................h.P.....p.p.....l.....h.s..p.t.....a.....h.....h.....h........p......s......t......K.hS.K...........S.....h..Gs..h.l..s................h...l..........p...............p......h.s................-......hR.....Y..a.hh......t...................s........h.....p.D.h.sh......s......p......t..h..h..t...p..h.N......-..lssthsNhhsRs.h..................................................................................................................................................................................................	1	764	1399	1855
+9167	PF09335	SNARE_assoc		SNARE associated Golgi protein	Mistry J, Wood V	anon	manual	Family	This is a family of SNARE associated Golgi proteins.  The yeast member of this family (Swiss:P36164) localises with the t-SNARE Tlg2 [1].	32.60	32.60	32.60	32.60	32.50	32.50	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.50	0.71	-3.91	83	15761	2009-01-15 18:05:59	2006-09-01 17:20:35	6	40	4479	0	3638	10044	3069	125.40	20	54.58	CHANGED	lP....sthlh..hsuGhhh........uhhh.....uhlhshlGshlGshlsahlu+hht.............pthhpphhpppthpt...hpphh.........pc..huh.hh............lhlhRhlPhlstshls..hhuGh.splsh.tpFhhsshlGthshshlhshhGth	.................................................................................lP..uphlh......hh.u.G..h.l.h......................shhh.......................shlhshl.uu...h...lGsh....lsa...h.l.G.Rh.hG.............................phhhp...h...h..h..p..p..p..t.....h...p..p.............s..pph.h......................p+...aG...h..hs....................................lll.s.R..a.lP..h.l...psh..ls...hs.AGh..s.p.hs......h.tp.FhhhshlGsh.hhshlhshhG..h..........................................	0	1172	2266	3020
+9168	PF09336	Vps4_C		Vps4 C terminal oligomerisation domain	Mistry J, Wood V	anon	Pfam-B_8681 (release 20.0)	Domain	This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerisation [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.87	0.72	-4.08	26	1201	2009-01-15 18:05:59	2006-09-04 10:04:39	5	14	381	41	789	1144	12	54.50	29	9.96	CHANGED	hlTPCSPGDPs.A.lEMoWh-ls....uccLhEP.slThpDFlKAlpss+PTVspcDlc+apcFTc-FG	.........................h............................p..l.......tpch......P..slshpDFpcAlpps..+sSVSppDlc+aEcasp-FG.................	0	272	408	623
+9169	PF09337	zf-H2C2		His(2)-Cys(2) zinc finger	Mistry J, Wood V	anon	manual	Domain	This domain binds to histone upstream activating sequence (UAS) elements that are found in histone gene promoters [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.05	0.72	-4.54	11	664	2009-01-15 18:05:59	2006-09-04 13:23:51	5	42	181	0	194	519	2	39.20	51	10.82	CHANGED	Hhpp.HuGINKoTotIApKYHWhRIKETVucVI+sCscCK	............HslA.HoGp-u.Tah..KloSKYaWPNlRKDVlKVIRQCcQC.h..	0	88	124	161
+9170	PF09338	Gly_reductase		Glycine/sarcosine/betaine reductase component B subunits	Mistry J	anon	Pfam-B_25756 (release 20.0)	Family	This is a family of glycine reductase, sarcosine reductase and betaine reductases.  These enzymes catalyse the following reactions.  sarcosine reductase: Acetyl phosphate + methylamine + thioredoxin disulphide = N-methylglycine + phosphate + thioredoxin Acetyl phosphate + NH(3) + thioredoxin disulphide = glycine + phosphate + thioredoxin. betaine reductase: Acetyl phosphate + trimethylamine + thioredoxin disulphide = N,N,N-trimethylglycine + phosphate + thioredoxin [1].	20.00	20.00	20.30	20.70	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.32	0.70	-6.30	16	404	2009-01-15 18:05:59	2006-09-06 15:52:04	6	3	133	0	71	362	11	324.90	29	81.50	CHANGED	M+LELGpIaIKDlpFGcpTcVcsGVLhlNKcEllchltp.D-+Ipol-l-IA+PGESlRIhPVKDVIEPRVKVEGsGslFPGhhuKV-.TVGpGRTHlLKGsAVV............ToGcIVG.FQEGIIDMSGsGAcYTPFS+hhNlVlls-sh-Glppa-HEp...AlRhsGLKAAtYLGEAu+slpPDElcsYETpPlhEpspcYPsLPKVuYVYMLQSQ..GLLHDTYVYGVDAKpIlPTllYPTEVMDGAIlSGNCVSACDKNsTYlH.NNPlIc-LYc+HGK-lNFlGVIlT.NENVhLADKERSSsasAKLschLGhDGsIlSEEGFGNPDsDLlMNC+KlEpcGIKTVllTDEaAGRDGsSQS.LADusscAsAVVosGNANpllhLPsM-KlIGcl..phl-slAGGasG......SL+tDGSI-sElQAIsGATsElGFspLoA+sY	.....................................................................................Lphtphhlpclpaup..pop.l.c.sssLhl.pc.p.h.th..h.t.....cphl.pphclcl.hpPs-.t.h.p.h..s.hh-slps.ts+hpGt......................lGpGhThsL.pG.shVh............hs..G........p............hu....p..-Gh.l-....t.h...h..s..t..s.....h....s.....t........plhl.hp........th..p.....ht..pt....h.hhu...hchs..a.l.s....p...hc.t....h...p...s..-..p.......h.ph..hhp.t.t....hsth.pVshlh.h.sQ....Ghha-s.........hhh.........G....h...p......hh.....th...........l.....Ps.hh.PpElhDGul.huh...shlusssKpsohpahppPll.cplhpccsp-lshhGVlhs.sps.h.s-K.hsuphsuthsc.hhssDGsllop.EGaG.NschDhh.shcplttpGl.sVhlo..........................................................................................................................................................................................................................................................................	1	42	66	68
+9171	PF09339	HTH_IclR		IclR helix-turn-helix domain	Bateman A	anon	Pfam-B_70 (release 18.0)	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-7.78	0.72	-4.37	93	11639	2012-10-04 14:01:12	2006-09-12 11:35:16	5	84	2544	26	3363	13801	1334	51.10	26	19.10	CHANGED	ulsRulplLchluppsps........h..sls-lAptsGls+uosaRlLpoLhptGalcpcs	.............................................slt+ultlLc..h...l.s..p.p.s.ss.....................h..sls-.lupp...s.....G..l.s.+.o.TsaRlLpo.LtptGalpp................	0	800	1991	2786
+9172	PF09340	NuA4		Histone acetyltransferase subunit NuA4	Mistry J, Wood V	anon	Pfam-B_29415 (release 20.0)	Family	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast [1].  NuA4 complexes are highly conserved in eukaryotes and play primary roles in transcription, cellular response to DNA damage, and cell cycle control [2].	20.90	20.90	21.20	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.82	0.72	-4.34	29	357	2009-01-15 18:05:59	2006-09-12 13:53:42	5	8	275	0	236	335	0	80.70	39	40.29	CHANGED	+pcLp.phlp+KppL-ppLssLEcpIYchEspYLp.....tsoshGNIl+.GF-sa..hpsss................ttsp++pttap-sDRlFShSSso.h	...................tcLt.phlp++pplp.cp...LssLEcp......IYshEsuYL-................pophhGNII.+.Ga..DpY...lpspp.......................................sutss+R..pppap-s-RlFSpSSlT...................................	0	85	135	199
+9173	PF09341	Pcc1		Transcription factor Pcc1	Mistry J, Wood V	anon	manual	Family	Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth [1].	20.90	20.90	21.30	21.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.31	0.72	-3.94	57	386	2009-01-15 18:05:59	2006-09-12 13:56:42	5	11	320	13	261	415	29	76.60	23	62.38	CHANGED	hphslplsFtotc.AplshpuLps-..sphptspsphphshps.s..............hLh..lphpA........p-sphLRsulNoalc.lplshcshpt	...............................thslplsaso.tc.A..plshpuLtsD....tphp.stsppph....shss.s..................................................................hLh..lphpA............pcs..+hLRsulsualc.lplshcshp......................................	0	72	146	210
+9174	PF09342	DUF1986		Domain of unknown function (DUF1986)	Mistry J, Rawlings ND	anon	Pfam-B_99782 (release 20.0)	Domain	This domain is found in serine proteases and is predicted to contain disulphide bonds (see Swiss:P98159).	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.99	0.70	-5.11	3	34	2012-10-02 13:45:52	2006-09-12 14:19:54	6	16	29	0	24	2142	2	201.90	31	10.89	CHANGED	N++sElV-sFc.....................--hcWPWlAcVYl-GshhCoGVLIDtSWVlVScSCLpslsLcHpYlSVVLGGuKTh+Sl.+GPYEQIhRVDCa+slP+ScllLLHLcoPloFS+HVLPTFVP-opNcNpocu.cCloVGQDD.hGRsKTluIaL.cNsTNCsScpl.CYK+cpKQP.h....lhN..stsMsSpHE.stlISCaTPpthsslscFT.............sss..sLKN.....sScthassS.pGVlV..C+sSRoGWaPsuhapapRGsC.GFccls.GVRoLE-uY+clQ-llHK	.............................................................................................................p.h..h.WPW...L.A.....c...l......a...........s......s.....G......c.....h....h.....Ch.....GlLl-.pWlLsp.puC.......l........p........s......l.......s.......h........p........s.....p......Y...l.......o........s....l.....L......G......t......u....+...........o....h......h.............h........c.........u.......s......a......p......Q.......I...........h..........V.......D.........p........h........c..................l.....................c.............o.............p........l......LL.....HLc.........p.........s.....p....a....o.+..a..V.Ph..hl...c....................t..p..ts.....C......l...u....l..h....p..sp..............p..........o..................t...l..h.....h.............s........p....s....C.....s...........Capht..................................................................................................................................................................................................................................................................	0	8	11	21
+9175	PF09343	DUF2460	CHP2217;	Conserved hypothetical protein 2217 (DUF2460)	Bateman A	anon	PSI2 target BIG_186	Family	This model represents a family of conserved hypothetical proteins. It is usually (but not always) found in apparent phage-derived regions of bacterial chromosomes.	21.90	21.90	21.90	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.96	59	277	2009-01-15 18:05:59	2006-11-08 13:52:02	5	4	254	0	88	226	66	193.60	38	84.33	CHANGED	H-lRFPh..sluhGusGGPERpT-lVsLusGtEcRNssWucuRRRYDAGhGl....RSh--lpsLlAFFEARpGphaGFRa+DhsDapSs.sstsss.tDQhlGh...GDGssspFQLsKsYsu......GtpsYtRsIsKPVsGoV+l.ulsuschttu....tatlDhsoGhloFs..psPssGstloAGFcFDVPVRFDTDplphSlsuFpAGpsP....slPllElRh	................................................H-lpFPh...sluhGusGGP-hpTclVshsoGhEpRNs.WupuRR+a-suhul...........+Shc-lptlluFFEAR+GphauFRa+D.hDapSs..t.................................................................................s.hDQslGp...GDGssspFQLhKsYss..........s.tsYsRsIs+PVsG.oVhl....uVsGschstu....taslDssoG.....lVT..Fs....tsPstssslTAGF..tFDVPVRFDoDplphsls.....sapuGpls.....slPllEl+...........................	0	20	59	68
+9176	PF09344	Cas_CT1975		CT1975-like protein	Bateman A	anon	PSI2 target BIG_184	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	25.00	25.00	29.30	29.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.06	0.70	-5.08	25	679	2009-01-15 18:05:59	2006-11-08 14:22:11	5	3	640	0	127	467	19	337.10	44	96.95	CHANGED	lplHlLpoassSNLNRDDoGtPKoAhaGGspRsRVSSQuhKRAhRpuhp.tthhst....hG.lRT++lsc..lhctltp................tuh......ctp...Atphscphhsshu.....Klpptppttt...........................coctLhalutpElstluphspcttpsspsspttth......pccpp................................ulDIALFGRMlAs...ss....phNV-AAsQVAHAlosHtlssEsDaFTAVDDLtp....--..sGAuahGssEFsSusFYRYsslDlcpLhcNLGGs.......p.........-hAtcslpAhlcAhspssPoGKQNoaAupshsshlhhph.tpspPhSLAsAFcpPV.......pspcs...hhpsulptLsshhpphcpsYGtt....pshhthsshssptt......s.psolccLlshlt	...................................IplHlLpuaPsuNLNRDDTGuPKTsl.hGGssRlRVSSQSLKRAhRsSthacps..lus........lGlRotRlucc.sAph.L..h-......................pG..l..-pc..cAhchut..plsshhG.............KsKpc+.c..cc..............................................-TcpLlalSssEh-sltsLApphsp-cc.s.sp.ccch.t.....h++cph..................................................................................AVDIAhFGRMLAs...ps.......chNV-AAsQVAHAhulpcs.h.lEsDaFTAVDDLp...........pss.....ED...uGAGHlGpstFuSAlFYpYhsIsh-hLlcN..Luus..............c..............tLAspslcAFs-AhlpssPTGKQNSFAu.+s.hAsaslsph.t.s-.QPhSLAuAF.cP..l......susc.......lpsulp+lsshtcshsplYspp........spssshsl.hspp...ss........................pssh.................................	0	38	93	111
+9177	PF09345	DUF1987		Domain of unknown function (DUF1987)	Bateman A	anon	PSI2 target BIG_79	Domain	This family of proteins are functionally uncharacterised.	21.30	21.30	21.40	22.90	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.29	0.72	-4.20	56	185	2009-01-15 18:05:59	2006-11-08 14:48:30	5	3	128	0	66	195	81	98.00	35	74.40	CHANGED	PpVpFcspsulhclpG-SYsEssh...sFYpPllsWLppYlpp..spptlphsh.cLtYaNTSSo+thhplhchL-ch.tppsspVplsWaap..p-DcchhEhGE-a	.......PtlpaDhpsshLplpG-SYPENuh...tFatPllpalcpYLsp............spp..........s..........lplcl.cLhYhNoSSsKslhslh-hL-ps.tppGppVslpWaY-..p-D-phtEhGE-F................	0	29	47	57
+9178	PF09346	SMI1_KNR4	DUF1988; 	SMI1 / KNR4 family (SUKH-1)	Bateman A	anon	PSI2 target BIG_91	Domain	Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation [1][2]. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems [3]. 	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.44	0.71	-4.13	178	1863	2012-10-01 20:46:44	2006-11-08 15:03:16	5	30	934	3	480	2059	25	133.60	15	53.86	CHANGED	ssoppplp...p.hEpp..luh.pLPps.a+phlp.........................................tthhhthtshshhthhhtthph..tthtphhphpphhpph..................................................................................................................................h.pphlshus...sssushhslchsstt................splhhhspc........tsp...hthl..................us..oFsca.......lpp	..................................................................hoppplp....p.hEpp.....hs.h....pLPps.apphhp...............................................s.ss..h..h...h...t...h.t...h...p..h..............t......hh......h..ttph........pthtt...h..hp.h...t..thhpt...................................................................................................................................h.tthl..shup.....sssu....s.h..lsl.-hpsst.t...............splh.h.hsp-......................................tpp.........hhhl.......................................up.....sappal..t.................................................................................................................	0	137	283	391
+9179	PF09347	DUF1989		Domain of unknown function (DUF1989)	Bateman A	anon	PSI2 target BIG_202	Domain	This family of proteins are functionally uncharacterised.	20.40	20.40	20.80	20.60	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.68	0.71	-4.80	144	1044	2009-01-15 18:05:59	2006-11-08 15:22:35	5	9	576	7	482	1045	1397	168.80	30	62.00	CHANGED	ppplsutsshuhtlcpGphlRlsDlcGsQssDhlhasAcc.hs.....ERhssscThpht...tsha.lssG..shLhSshs..Rshholl.pDo..........sGhHDslsusCsspp.phh.aut..pph........csCp-Nhhtulu......paG...ls.......pcDlssslNhFhsVsls.ssGp.lphtsshSpsGcaVpLcAEhDll	......................p..hlPutsshuhtlptGphlRlhD...lcGs....QssDhhhasAcs..p.....ERhssscThphp....pssalssG..shLaSshs..RshhoIltDo............................sGhHDsluusCssppsphh.aGp...pph...........csCp-Nhhhulu..............caG..........Ls.............................ppDlssslNhFhslsls.s..........cG..........p.....ht....hpssh.opsGcal-lcAEhDll................................................	0	123	281	393
+9180	PF09348	DUF1990		Domain of unknown function (DUF1990)	Bateman A	anon	PSI2 target BIG_236	Domain	This family of proteins are functionally uncharacterised.	20.70	20.70	20.70	20.70	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.87	0.71	-4.60	30	289	2009-01-15 18:05:59	2006-11-08 15:25:40	5	8	240	0	132	262	2	152.20	33	78.55	CHANGED	oYsplGuotttth...........ss.....GappsctcshlGpGct.......sF-pAspAlhsWphhctuhlplh.....ssspsstsGssVslp.hthh.......hhhhhsssRVlhll.....-Es.........c+hGFuYGTLsGHsEsGEEpFhlch......s.ssGpVahclpAFSRPAph...hu+luhPls.+hhQ+ths++.hhpul	...................................................................................htsot.t.h.........ss........Gaphhchpt.lGpGpt.......tFcpA..spulhpWthpct...uGlpV..................ssspsstsGssVh....lt.hth.........................ltsPsRVVaVh................--s.........................................shtGFuYGTLsGHs...sGEEpFsVch.......c..tsusVahplhuFSRPAsh...hs+hutPls.ph.hQ+hhspR.hhcuh.................................	0	55	101	123
+9181	PF09349	OHCU_decarbox	DUF1991; 	OHCU decarboxylase	Bateman A, Percudani R	anon	PSI2 target BIG_237	Domain	The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576).	20.50	20.50	20.60	20.50	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.00	0.71	-3.94	139	1098	2009-01-15 18:05:59	2006-11-08 15:27:51	5	15	925	26	464	1030	527	154.20	29	57.32	CHANGED	hs...shspspF.stthsslaEpo....sWluctshs.......tp.....sasoh.ssLhsuhtphlpsss....................pppphsllpAHP-Luu+hh.........stpLospSssEQusAGlsph................ssp-hpc.hppLNssYcp+F.GFPFllsV+.....G.ps+.pp....Ilsshp............................pRl.pNs...cpEhppAhpplp+IAthRLpc	............................sthst.pph.htthsslhEps....sWlschAhs...............t+.....Pasoh.ssL...hsshpp.h.h..p.shs.......................pspthsllpAHPcLus+h................ttph..o..s.....pS.s..pEQ..u..uuGl.sp.h................sspphpp..hppLNttYc.p+F.GasFl........l....slc......G....p.s+...pp.....ILsshc............................pRl..pNs......ppEhppAhpplt+IAthRLp...........................................................	0	124	273	377
+9182	PF09350	DUF1992		Domain of unknown function (DUF1992)	Bateman A	anon	PSI2 target BIG_207	Domain	This family of proteins are functionally uncharacterised.	20.60	20.60	20.70	20.70	19.20	20.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.13	0.72	-4.15	74	1227	2009-01-15 18:05:59	2006-11-08 15:29:28	5	11	1099	0	334	771	12	84.10	39	45.09	CHANGED	lsEcpIpcAhpc..G-F-s...LsG.tGKPLs...hccs..shhs.phphth+llpssGhlP.tlpLp+El.............................tp....lpchlsph	.................hAEc+It-Att+....G-FDN...LsG.pGcPL.....L-Ds...Sal..Ps-lRhuYRl....LKNAGh.lPPplE.p+Eh...........................hp.....Lh-hLp..thpp..........................................................................................................	1	97	193	267
+9183	PF09351	DUF1993		Domain of unknown function (DUF1993)	Bateman A	anon	PSI2 target BIG_238	Domain	This family of proteins are functionally uncharacterised.	20.40	20.40	21.50	22.30	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.81	0.71	-4.31	60	472	2012-10-02 14:44:17	2006-11-08 15:31:17	5	8	351	6	234	454	160	160.20	38	87.75	CHANGED	hYssoVPs.ahp.....hLssLsslLcKApsaApspslcsss.LlsuRLhPDMhPLstQVphAs-tA+tssARLu....Gh.....-sP...........shs.DsEso.Fs-LpARIucslsalpulssspl..-usps+slsh......hsspphshsG.p.sYlhsauLPNFYFHloTAYuILR+pGVtlGKtDYlG	.......................hYpholPshhp.hLpsLsslLsKA.pu..a.Apspt.hc..sss.llsuRLhP..D..............Mh......PLstQVphA.sDtA+tss.A..R.Ls....Gh....-sP................phs..DsE..sT.as-LpuRIscTlsaLps..l..s...s.ppl.-us....ps..+..p.l.sl.................hsstshph.s.G.p.sYlhsauLPNFaFHlTTAYsILRHpGVtlGKhDYlG..........	0	39	113	189
+9185	PF09353	DUF1995		Domain of unknown function (DUF1995)	Bateman A	anon	PSI2 target BIG_247	Domain	This family of proteins are functionally uncharacterised.	26.00	26.00	26.50	26.50	25.40	25.90	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.50	0.70	-4.71	39	273	2009-01-15 18:05:59	2006-11-08 16:33:42	5	9	102	0	174	269	140	221.80	21	67.59	CHANGED	L.PssLppA..........hpputpAltsALt..sspsRhp....l-lpFs..sL................plhsluhphhpt...Ltp......ts.pshhllasDuGuuALApR-h.sshs......plhshsphh.st.ts.................t.........chhlhVsPpsh-....l-plEtlscthss.............psllhlNs+L-...Dsu.lG..lG.su.Rph...RcpFluoapssYaLcPL..ps....................GALh+s.aP......ssWplapps......s..ssYphlsphppRPss-plsth	..................................................................................Ppshpph..........htputpAhttAlp......tttt+h.....l-lph.P.....tL.....................................................p.hpluhthhpt...htp...............ps..pthtllaP-s....uts..shAppph.tshs..................hplsslssht..h.t..sts......................................................................s.....chhlhls...Psshp.......lsplcths.pthss...........................+Pll.lh.NscLc......shp.su....................hu...hss.+.ph............+pp..Fl..ssa..ps.....sYhl+sl..ss.....................GslhRs.YP........s.Wplhhcp.........s.spYt..hl.tp..tp.+.Pshpplp.h....................................	0	67	131	161
+9186	PF09354	HNF_C		HNF3 C-terminal domain	Bateman A	anon	PSI2 target BIG_367	Domain	This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterised by the FxIxxIL sequence [1].	20.80	20.80	21.10	21.10	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.81	0.72	-2.83	26	211	2009-01-15 18:05:59	2006-11-09 09:21:50	5	5	86	0	97	189	0	62.20	43	14.86	CHANGED	sHPFSIsNLM..Sspp..............pKh.DlK.sY-th..pY.uuY..............ssh.shshs........psshp.ssshsssss..........YYQ	..NHPFSINNLM..SsEpp.............pKh.DlK.sY-psh...pY..suY..............sus.sss.s.......ssctshc..sss....ss..............YYp............................................................................	0	16	25	52
+9187	PF09355	Phage_Gp19		Phage protein Gp19/Gp15/Gp42	Bateman A	anon	PSI2 target BIG_98	Domain	This family of proteins are functionally uncharacterised. They are found in a variety of bacteriophage.	21.10	21.10	21.30	23.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.49	0.71	-4.25	8	161	2009-01-15 18:05:59	2006-11-09 09:41:09	5	1	154	0	13	124	2	113.30	32	84.71	CHANGED	LhRsLcsDEpcRApALLcsVscplRhEhs+sG+DL-shlstcPsYhtsVhpuVsl-lVARslhsusc.EPhuphSEoshsYShSuoYhls......uGGLhIcDSELcpLGL+K.............pRhGslshYGhs	........hhRsLss-.EpspspshLpsspchlRpchs....-LDt.h.....sstcs.hhtsV......lcl.Acslhp..hsc....sP...u...hoET..sGsYoaphoatls......sGsLhIpcpEhcpL.....Glp+.............p.Rhu.h......h..................	1	1	5	9
+9188	PF09356	Phage_BR0599		Phage conserved hypothetical protein BR0599	Bateman A	anon	PSI2 target BIG_187	Family	This entry describes a family of proteins found almost exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. An apparent exception is Wolbachia pipientis wMel, a bacterial endosymbiont of the fruit fly, which has several candidate phage-related genes physically separate from obvious prophage regions.	20.40	20.40	23.90	22.50	19.70	16.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.87	0.72	-3.84	73	343	2009-01-15 18:05:59	2006-11-09 09:42:31	5	5	305	0	99	303	38	76.40	37	28.73	CHANGED	suaFstGplshhsGsssGhsttl+pcps.......stlpLhpshstslssGDtlplhAGCDK...phsTC+sKFsN..hlNF+GFPalPGpD	............................saFstGhltahsGs.stuhthtlttcts..................stlpLhtsh..slss....G-thplh...sGCDK...ph.sTCcsKFsN..hlNFRGFPalPupD.....	0	20	64	76
+9189	PF09357	RteC		RteC protein	Bateman A	anon	PSI2 target BIG_10	Family	Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer [1].	20.60	20.60	20.70	20.90	18.50	20.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.38	0.70	-4.49	17	391	2009-01-15 18:05:59	2006-11-09 09:46:05	5	2	123	0	52	328	12	175.30	27	80.01	CHANGED	pFFK.hKP.hhu+LlaasclaphEhppPpGshcstppahppclpcLpphhpp...shsFhpYh+sttshhDcpYFsRsphclt..ssphhhppD.pFoTu......aDhhsApllAs-hl.hahscclcthtpt........tt...tpslpWTusKhsLlELIYALpuptslNsGphsIKclushhpplFsl-L.tchY+oYh-lKpRKp.sRTtFLccLp-sL.p+Mpc-D	..............................................................................................................................hhh..phhth..ths...t..t.p...thh.tph.tlp....t......hhtYhc.t.p.hs...h.p......tp.ph......h.hp.s..Fsp.......hp.hhut...s..hh.....tph.............................lpWTust..hsLlELlYuL......sts..s..l...s...s..G....p...h.slpcluthhpplFslcl..sc..hY+hahc.l+pRKt.sRThFLDpLp-pL.c+M.c...............	0	19	42	52
+9190	PF09358	UBA_e1_C		Ubiquitin-activating enzyme e1 C-terminal domain	Bateman A	anon	PSI2 target BIG_346	Domain	This presumed domain found at the C-terminus of Ubiquitin-activating enzyme e1 proteins is functionally uncharacterised.	29.20	29.20	29.40	30.30	29.00	29.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.46	0.71	-3.96	57	525	2009-01-15 18:05:59	2006-11-09 09:54:28	5	25	308	2	345	522	14	123.90	36	12.42	CHANGED	a+NuFlNLALPhhshoEPlsssctph.....pchca...............TlWDRaclpt......s........hTLpchlcahcpch.sLclshlotGs.shLY..ssa.......tcpp-RlshplscLlcplscp......l.stpchlslplssp.D.psspDl.-lPh..l	......YKNuFlNLALPaFuF....oEPlss.s+tca.......pshpa..........................TlWDRaclpu.........p.......hTLp-hlcahccc......s.L-loMlSpGs..uhLY...usa.......s+hp-RL................shpho-lVcplsKp.................ls.sph+tlll-lssp.....D..pss-..DV..-lPhl.....................	0	128	190	271
+9191	PF09359	VTC		VTC domain	Bateman A	anon	PSI2 target BIG_223	Domain	This presumed domain is found in the yeast vacuolar transport chaperone proteins VTC2, VTC3 and VTC4. This domain is also found in a variety of bacterial proteins.	20.80	20.80	22.40	20.90	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.83	0.70	-5.39	44	868	2009-01-15 18:05:59	2006-11-09 09:58:08	5	23	587	8	395	831	403	232.00	26	51.08	CHANGED	sRpshKahlc.cslhpl+ttlh++Lslhsasssp.......................................................s.sIsSlYaDsss.hchYpp+lp+hpsspplRlRWY.up..t.........splFlEpKh+....ppshsst......KpRhplcp+.lpsal..ssp........t.................................................................................................................phpp.pphssElp....hlhpp.pLpPhlpspYpRsAFphss.-splRlolDoslph..........................................................................................................W++h-ls...hp.s...hlttsth..hs..aullElKhps.....................chspWlp-Ll..uchspplspFSKYhpGhAsLa	..................................................R.phKahlp.pphhtl......pthlh..phhsh..assp..................................................................................................t.sIsSlYFD..s..p.hphapp..clp...ph....p..........tpcplRlRhY..st..t.......................splalEhKp+.................................tpshss............KtRh.slp.t.ppspthl.......pGph.................................................................................................................................................htp..pplh.pElth...hh.hpt...pLpPhhhstYpR......pua......t......h..t......-......s...........p....l.R...lolDpslp..................................................................................................................a+phcls.....t.s.....l.tt............hslhElKhps..........................thPtWlpcll......schshtsspFSKaspuht........................................................................	0	147	259	354
+9192	PF09360	zf-CDGSH		Iron-binding zinc finger CDGSH type	Bateman A	anon	PSI2 target BIG_227	Domain	The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family [1]. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, Pfam:PF10660 [2]. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm [3].	21.20	21.20	21.20	22.20	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.37	0.72	-4.12	158	1359	2009-01-15 18:05:59	2006-11-09 09:59:42	5	27	737	21	688	1317	995	42.40	34	41.39	CHANGED	sppsPhtl............................phpp...pphhhCpCGpSp.spPaCDG.oHp	.............................................................t...sPhhl............................p.pp...pphhhCpCtpSp.sh.....PaCDG.SHp...	2	241	412	580
+9193	PF09361	Phasin_2		Phasin protein	Bateman A	anon	PSI2 target BIG_183	Domain	This entry describes a group of small proteins found associated with inclusions in bacterial cells. Most associate with polyhydroxyalkanoate (PHA) inclusions, the most common of which consist of polyhydroxybutyrate (PHB). These are designated granule-associate proteins or phasins.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.01	0.72	-3.99	132	960	2009-01-15 18:05:59	2006-11-09 11:03:55	5	1	504	0	408	873	126	99.50	18	65.25	CHANGED	hcphtstp.+ssh-s....hhshsstshcGhpclsphshphs+sshppuhstscplhusKssp-hhp.l...Qsphspst..hEphlutu+clt-lsspstp-hhcshcsphs	................................................pph.stt.cpsh-s....hhthsphshcu....h....ppl........sp...........hplphs+sshppshsp.h.cph....hs.sK.s...s...pch...hp.h....Qsph.hppt..h-phhs.pu+cltplsppstp-htc.hptph..................	0	92	225	298
+9194	PF09362	DUF1996		Domain of unknown function (DUF1996)	Bateman A	anon	PSI2 target BIG_243	Domain	This family of proteins are functionally uncharacterised.	19.90	19.90	20.00	20.30	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.90	0.70	-4.67	63	716	2009-01-15 18:05:59	2006-11-09 16:06:26	5	20	264	0	462	652	24	214.10	31	52.22	CHANGED	DPlVsPGth.ou.HlHplhGusuFshsh.s...h-.hppusCToCshsp.DhSsYWs.....ssLYa.ct.pN.........Goh..chVP.................GuhslYYhtt..............ttslpAFP...Ga.....RMlsGssttp....................t.tts...tptslsapChsstttt.........................spsaPspsCs......sG....lptslhFPoCWD.GpsLD.o.sc..................HpoHhAYPs....th.s.....sGs.CPsuaPl+lPplhaEshWDTstassts...t...ssFshSs..............GDs..oGYuhHuDFl.GW	...............................Dslh.PG...ss.HhHphhG..s................ss........hshs..s......hp.ht.tu..s..sToC......p.pt.DhSsYWs.........Ps.lhh........s............G.p.h..hss..................uthp.sYYhtt.............................ttlpsFPt.....G..h+h.lsGcsptp.................................hsppslsatChssps.t............................t.ths.s..p...Cs......sG....lphp...lhFP......s..CWD.GhsL-.o..sc.............................a+sHhuYss.............t........tGt.CP.s.s.aP.l+lPplhhclhWsss...t.hs...s.ht.............p.h.hhS...................G.......ouashHuDF..htGW.............................................................	1	164	312	412
+9195	PF09363	XFP_C		XFP C-terminal domain	Wood V, Bateman A	anon	Wood V	Family	Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22 [1].	21.20	21.20	21.60	21.80	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.18	0.71	-4.89	93	1022	2009-01-15 18:05:59	2006-11-10 17:50:17	5	13	862	16	389	968	40	198.30	45	25.77	CHANGED	KQPp.QaLoh-pAhpHCspGlGIW-WAS.sD....putE...PDVVhAsAGDlPThEsLAAlslLRcphP-LKlRhVNVVDLh+Lpsp..s..-HPHGLSDc-F.......DslF.TsDKPVIFAFHGYPhLIH+LsY+RsNppNlHVRGY+EcGohTTPFDMsVhNclDRF+LshDslcRlPp....ltspuutlppphccplhcH+pYlpcaGpDhPElpsWpWs	.........KQPp.QaLoh-EAtpcsspGlulW-.WAS..s-...........ps.tE..........PDVVhAsuGDhPThEsLAAlslL+..............cphP-..LKlRhVNVVDLh+Lpss.........p....p+P+GLSDc-F.......DslF..Tp.DKPVlFAaHGYshLI+cLhacRs...N....t...c..NlHV+GYcEc.................GshTTPFDM.tVlNclDRF+Lsh-slc....clst....................htspuuth....hpph....pstlhcH+pYl+cpGp.DhPElpsWpW..............................................	0	98	230	324
+9196	PF09364	XFP_N		XFP N-terminal domain	Wood V, Bateman A	anon	Wood V	Family	Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22 [1]. This family is distantly related to transketolases e.g. Pfam:PF02779.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.05	0.70	-5.91	6	1135	2012-10-02 16:07:47	2006-11-10 17:51:28	5	14	914	16	430	1562	249	358.00	48	46.75	CHANGED	hlo-ctLcplDtaWRAANYLulG.IYLp-NPLh...+EPLc.EclKpRLlGHWGTsPGloFlYAHlNRlIpKaDtsMlYlsGPGHGGPAhlusoYL-GoYoEhYPclopDcpGhp+LF+QFSFPGGIsSHhsPETPGSIHEGGELGYuLSHAYGAlhDNP-LIVsCVVGDGEAETGPLATSWHSNKFlNPtpDGAVLPILHLNGYKIuNPTlLuRIs--EL+shFcGhGYcPhaVpu....cDs.shH+hMApshDpsh--IpsIQ+sAR...sssps.RPcWPMllhRTPKGWTGPKa.......lDG..hhsEGoaRAHQVPLuss+cssupLp.LccWhcSY+PEELFDtsGslptslcshsPcG-KRMuuNPpANGGlLpcsL+lPDa+cYuls	...................................................................................................s..s.p.Lptlc...taWRAANYLol..............GQlYLh...c.NPLL...........+cPLp..-clK...s+l...l....GHWGT....s....PG.....NF...lYuHLN....Rl....I...p...c...h..s.......ls.....h..........ha.ltGPGHGGPuh.lu.ss.YL-Go.Yo.E.h.Y.P.c.lo.pDppGhp+LF+pF.....S.F.......P....G.G........l.s.....SHs.u.P.E..TPGSI..H..E..G..GEL....GYuLu....H....A.....a.....G....A.....s.....h.....D.....N.....P....D....L....l...sssllGDGE.AE.T.G.PL..A.sSWa.SNKF.lNP.h....pDG.AVLPILHLNGaKI..u.N..P.T..lL.u.Rho.c.-E.L.pphFcGhGacPh.a.V-G.............cD....tsh.Hpt...h.AtshDpslpcIptIQppAR.................p.s..s...s.s..+P..pWPMIlhRoPK...................GWTGP.+p.......lD.G..p.lEGsaRAHQVPlsss..p...p.s..pHh.chLpp.Wh+SY+P-.ELF....D.......p.......s.G...p....l..h..s-lt.t.....l.sP.p.G.p.p.R.MusNPhsNGG.h.lh....+sLphP.Da+caAl............................................................................	0	111	259	365
+9197	PF09365	DUF2461	CHP02453; 	Conserved hypothetical protein (DUF2461)	Bateman A	anon	PSI2 target BIG_248	Domain	Members of this family are widely (though sparsely) distributed bacterial proteins, about 230 residues in length. All members have a motif RxxRDxRFxxx[DN]KxxY. The function of this protein family is unknown.	20.80	20.80	21.40	21.20	20.20	18.40	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.21	0.70	-11.38	0.70	-4.94	99	698	2009-09-11 12:04:33	2006-11-14 14:11:37	5	3	644	0	255	606	173	203.20	28	84.13	CHANGED	sssshpFLpcLp..tNNsR-WFpspKspYcp.l+pshhshlspltspls.phcsph.s..h..psslaRIaRDl.RFS+DKoPYKsphusth.ptt.........pp....tsu...aYlclps.st..shluuGhap.....PpsptLpplRppIppsssp...hcpllpphphppha..............................t..s-pLKpsP..................+..Gasp..ccPhl-hL+pKsahshpphss.ptlhsschhcplsptapthtPhhca	................................................................t..pshpFLppLp..tsNs+pW...........Fpp............H+s................pY-p.lcpshpshlppltspht.phc.th.t.....tcs.laRIaRDs.RFS+D.KoPYKsphuuhh.pst...............tchs....tsuaYl...c..lpP..st......shlu.....sGhap.....sp.pstLtthRptItcpspt.......appll.pshphptha...................................................................hst-p..LK..psP.....................................................+..Gast..-hshl-hL+pKsassht.phss...chl.h.s.s.c.hhppltchapthpPhhca.......................................	0	79	170	223
+9198	PF09366	DUF1997		Protein of unknown function (DUF1997)	Bateman A	anon	PSI2 target BIG_266	Family	This family of proteins are functionally uncharacterised.	20.80	20.80	21.60	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.79	0.71	-4.48	34	280	2009-01-15 18:05:59	2006-11-14 15:55:48	5	4	121	0	159	288	167	151.10	21	67.50	CHANGED	sp.........tls.cYLpp.pRhhpshh.cshclptLsc.....spa+h..........pltshphhth.plpPslslclhspsss..............h.hp..shclcGlshl.......scaslshcupl..........................tsppstLpucscLsVslph.PthlphlPcsllcuoGcp...............................................lLptlltplppRlsppLhpD....appahtt	.................................................................................................t...lt.cYLpp.tphhpthh..cs..p....hpt...ls.c...........ppach.................................phh.hth.hth.plpPhlslplhspsps.......................h.hp..ph..cl.cG..hsh.......sppas.l..s..hpuplh..p........................................tsstsplpsch.clsV.slpl.P.slphlPp..sllcssGst...............................................lLppllpphpt+hhppl.pDappah..t.......................................................................................	0	37	94	136
+9199	PF09367	CpeS		CpeS-like protein	Bateman A	anon	PSI2 target BIG_280	Domain	This family, that includes CpeS proteins, is functionally uncharacterised.	20.60	20.60	20.80	21.60	20.20	19.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.92	0.71	-4.36	66	209	2009-01-15 18:05:59	2006-11-14 16:11:35	5	3	80	1	90	233	201	158.60	29	89.90	CHANGED	shtpFhppStGcWhSpRosHpL...sh..pcs..EsspSplslp..lssscsplhpls...p..tlsss.thhsuhthpWpup.phpp...pspsssslhhhlP..ts..ppGtLLRstGYsEphss...supaphssDs.sLsLpTcYsss.hspERlWFsssslR.hRsSslpphsGhs.......pso.FsoElRp	....................hhpFhptStGpWhSpRosHpLsh....pcs....EpspSplhlc..Lsssssplhpls...p.hplsss...thhsGhplpWpup.thsp...psppusslhshlP..ps....ppGhLLRspGYs.Ephss.......supYphsp-s.sLsLpTcYpph.hstERhWFsssslR.hRsShlpphsG.s........hsoFsoEhRh......................................	1	11	50	81
+9200	PF09368	Sas10	Sas10_Utp3_C;	Sas10 C-terminal domain	Bateman A	anon	Bateman A	Domain	Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.	25.00	25.00	26.60	26.60	23.70	22.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.58	0.72	-3.81	35	308	2009-01-15 18:05:59	2006-11-15 10:51:18	5	4	279	0	228	307	3	76.10	46	13.75	CHANGED	hssDuKRtIohpItKN+GLT.+R.pKcp+NPRVKpRtKYcKuhp+h+ophpsh+....pppus...YuGEhoGI+ssls+SlKl	....h.ttsuKRuIoYpItKNKGLTP+R.pKcsRNPRVK+RcKac+App+h+ut.hpsh+.......cppss...YuGEhoGI+sslsKSlKL......	0	82	128	188
+9201	PF09369	DUF1998		Domain of unknown function (DUF1998)	Bateman A	anon	PSI2 target BIG_296	Family	This family of proteins are functionally uncharacterised. They are mainly found in helicase proteins so could be RNA binding. This family includes a probable zinc binding motif at its C-terminus.	24.20	24.20	24.20	24.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.22	0.72	-3.41	165	1448	2009-01-15 18:05:59	2006-11-15 11:31:00	5	16	1110	0	569	1299	129	85.60	28	7.75	CHANGED	uhpHALhpthsh..hhthsps-l.shshh.t.........t.ttsslhlYDuhsG..GsGhsppl.....hct..htcllppAhchlpt..........................C..s..C...............p..sGC.sCl	..............................................................shpaAlhthlsh....hh.tss.ps.......-l..shsshhps.........................sthsslhlYDuhsG...GsGhsp.ph........hct.....htcllptuhchlpp...........................C....s...........C..............................................p..sGCssCl................	0	196	395	515
+9202	PF09370	TIM-br_sig_trns		TIM-barrel signal transduction protein	Bateman A	anon	PSI2 target BIG_293	Domain	This domain is likely to have a TIM barrel fold related to IGPS. Although this family of proteins are functionally uncharacterised this domain is found as an N-terminal domain of sigma 54 -dependent transcriptional activators (enhancer-binding proteins) suggesting a potential role in signal recognition/receiving and signal transduction.	25.10	25.10	25.20	26.00	24.70	25.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.60	0.70	-5.33	20	371	2012-10-03 05:58:16	2006-11-15 17:30:52	5	9	289	6	140	329	41	255.50	56	79.87	CHANGED	pplL.cphRpplppG.pPIlG............uGAGoGLSAKstEtGGlDLIlIYNSGRaRMAGRGSLAGLLPYGNAN-IVl-MA.pEVLPVV+c.TPVLAGVsGTDPFpsh-pFLscLKshGFuGVQNF.PTVGLI..DGpFRtNLEETGMGYshEVEMI+tA+phsLLTTPYVFssc-ActMs.cAGADIIVsHMGLTTGGsIG....AcTuhoL--sVphlsslscAA+slssDlIVLCHGGPIApP-DApalLc+sss.scGFYGASSMERLPsEtAIpppsppFKsl	...................t.plLp+h+ppItcG.cPIlG..................uGAGTGlSAKstEAGGhDLIlIYNSGRaRMAGRGSLAGLLsY.GsANpIVl.-MA..pEVLPVVKp.TPVLAGVsGTDPF.p..ph-tFLcpL+shGFuGVQNF.PTVG.....LI..D..GsFRtNLEETGMGYsLEV-MI+hAHchsLLTTPYVF.ss--AhsMs.cAGADIlVsHhGLTTuGsIG....A.c...T..A.....h.oL--sVthlpphtcAA.cpV.psDl..IVLCH.GGPIupP-DApYllcpstt.scGFaGASSMERLPsEtAlpppscpFKsl.........................................	0	40	93	117
+9203	PF09371	Tex_N		Tex-like protein N-terminal domain	Bateman A	anon	PSI2 target BIG_312	Domain	This presumed domain is found at the N-terminus of Swiss:Q45388. This protein defines a novel family of prokaryotic transcriptional accessory factors [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.09	0.71	-4.98	145	3396	2009-01-15 18:05:59	2006-11-15 18:19:14	5	18	3331	3	724	2645	145	190.50	46	25.65	CHANGED	lApELs.lpspQVpuslpLLDEGsTVPFIARYRKEhTGuLD-sQlRplp-RhpYL+cL-cR+pslLcuIcEQGKLTsE...LcppIpsApshscLEDLYLPYK..KRRT+ApIA+EtGLEPLAchlhspspt.....ssp.ptAtpal.....st-.......tt....VssscpALpGA+...cIlAEphuEcAclRpplR..phhhcpGh.lpo.pl..hpsccc-s	........................................................................................................................IupELs.hp.pQlpuslp.L.L.-.E.GsTVPFIARYRKEhTGu....LD-sQlRplc-R................hpYL.+pL--R+pslLc..sIp...EQ......GK......L...Tc.E...Lcpt.ItsupshscLEDLYLPYK.....K.RRT+ApIA+.........E..tG....LEPLA-h.lhspspp.................ss-..ppAtpal.................st-................t...........Vs..sscsALcGA+......pILsEphuE-AsLhsplR..phhh.c.p.u..h.lsSpl..hcscccE.s....................................	0	230	452	608
+9204	PF09372	PRANC		PRANC domain	Bateman A	anon	PSI2 target BIG_313	Domain	This presumed domain is found at the C-terminus of a variety of Pox virus proteins. The PRANC (Pox proteins Repeats of ANkyrin - C terminal) domain is also found on its own in some proteins. The function of this domain is unknown, but it appears to be related to the F-box domain and may play a similar role.	23.40	23.40	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.37	0.72	-4.02	77	463	2012-10-02 00:56:31	2006-11-16 17:40:10	5	59	47	0	6	429	0	93.10	24	17.31	CHANGED	hssho..laDllhspsp...phhh+hlps.phhph........ph..lYtphlcchIppuhpRpphlppslphlsshhpp......shWshLPhEI+hpIlphLssp-Lphlhp	...................tsholasllhspsp.....phhhRY.hps..p.hhph........h....sh.plYsshlcphltphhp+pphlsp.llcplpss.............shhopLP.EIphpIlphls..-Ltph..h...................................	1	0	6	6
+9205	PF09373	PMBR		Pseudomurein-binding repeat	Steenbakkers P, Bateman A	anon	Pfam-B_12784 (Release 21.0)	Repeat	Methanothermobacter thermautotrophicus is a methanogenic Gram-positive microorganism with a cell wall consisting of pseudomurein. This repeat specifically binds to pseudomurein. This repeat is found at the N terminus of PeiW and PeiP which are pseudomurein binding phage proteins.	24.90	24.90	25.10	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.08	0.73	-7.34	0.73	-3.77	49	106	2009-01-15 18:05:59	2006-11-27 14:56:45	5	26	19	0	90	104	9	32.50	28	8.87	CHANGED	sssplohpphhchss+lhsa.hpppsRh..Pshlsl	..t..splshsphlchssRlhsF.hppssRh..PsYls.....	0	37	67	76
+9206	PF09374	PG_binding_3		Predicted Peptidoglycan domain	Moxon SJ, Bateman A	anon	Pfam-B_8737 (release 8.0)	Domain	This family contains a potential peptidoglycan binding domain.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.46	0.72	-3.99	20	823	2012-10-01 23:43:47	2006-11-30 10:00:54	5	12	535	9	152	611	209	75.60	34	37.79	CHANGED	pAs+hLQ+hL......u.....ltsDGhIGspTlsAl........ssts.ssLhpthssuRhpaYhcLs.......................stspFscGWhsRls	...........................ss+hLQRhL..............u........l.tsDGhIGspTL...uAl..................sppu.tt.sL.lp.sLs...stptpa.Yhpluttp....................spppF.hhGWlpch....................	0	30	90	125
+9207	PF09375	Peptidase_M75		Imelysin	Bateman A	anon	MEROPS	Family	The imelysin peptidase was first identified in Pseudomonas aeruginosa. The active site residues have not been identified. However, His201 and Glu204 are completely conserved in the family and occur in an HXXE motif that is also found in family M14.	21.10	21.10	21.10	21.10	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-12.04	0.70	-5.10	169	1931	2009-01-15 18:05:59	2006-11-30 11:01:45	5	5	1429	10	414	1465	252	267.80	27	74.43	CHANGED	shssY.....pshhps.spsLtsu...spshs..sssst...............ssLptA..+sAahsARhsappsEshph.................s.h...........................t.tlthWP..sc...........uhl-hshssh...............................t..hssp.ht................sssspGaHAlEalLasps.......................s.t....t..sth.................................sphlp..uhustLhscsppltspWpt.........tshttth.....................t.tt.......ulp..pll...sGhssh.ls-lusp+.ls...sh..............ps.ptcspaScsohtshhs.slpGhpsla.s.............sulps.ll....tpp.ss..s....Lssplcsphss......shstlstl.ps.........shs..................ptl...ssspspth...........lps.h....suLsp.t.spl	......................................................hhssY.csalps.sppLhps.....scsFs......puh...ps.................sclppAKsha.hssRhhYpchEsltt..........................................................th.......uplDhplcup....................................tssh.pt.c.h...........................ssshoGaHtlEhhLasps.......................s................................................................sphhcthAspLhsDspcLppphssht..................h................................................................................ssp.phl....sGtssL..lpElAssK.ls...............................sEE-h...a.S..c.osLhD.apA.NlcGspp..lh.................................shlcs...h...l.......ppp..s.......p....LssclpspFppspshLsph..ps...............p.t......................ppl.......sssstpth...........hss..l...suLsc.hut..............................................................................................................	1	114	235	339
+9208	PF09376	NurA		NurA domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This family includes NurA a nuclease exhibiting both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA from the hyperthermophilic archaeon Sulfolobus acidocaldarius [2].	20.60	20.60	20.70	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-4.89	65	438	2012-10-03 01:22:09	2006-12-01 16:54:16	5	2	287	10	251	429	41	278.20	14	74.78	CHANGED	tplhAlDGS............phth.phpsshhhhlhuhuhsstthtphthhthh.th.hh...............................................................cpthphhhthhEht...............................hhtttppsclllhDGslhtphh........................................................................................................................................h...thtchltth.phlct..........hsllulsKshpspplhsth..........................................................h.Dttllpthh.p.................s.pt.h.............................................hhhtthhtshp.hhhhYlph........ttss.lh+lE........h...................spstcllstlt...............................................hsspGYPhs...LthAcchu+l	...................................................................................................................................................................................h.phhulDGS............pht...h..phtths..hhhhhs....hu.h..h.s.ht.ht..p.h.thh..h...h.shh....h..h...t............................................................................................................pphhp.h.hthhEht......................................................hh..t.t.t.pp.ss.lllhDGsL.hhhhh........................................................................................................................................h...tht.ph.lt....h..phlcp.............th.llu.llKpsps..p...p.hhphh................................................................................h..tDh.t.lht....thh.p..............................................ss.pt.....h.h...................................................................................................hhthhtphp...lhhhYlph.......................sstlh+lE........h....h............................................tp.pchlshlh..............................................hhp.st.G....aPhs...LthAcp.sph..........................................................................................................................	1	91	160	213
+9209	PF09377	SBDS_C		SBDS protein C-terminal domain	Bateman A	anon	Bateman A	Domain	This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.  Members of this family play a role in RNA metabolism [2] [3].	21.20	21.20	22.80	21.20	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.38	0.71	-4.43	27	515	2012-10-02 20:07:24	2006-12-06 09:57:19	5	6	468	6	343	502	98	134.40	28	49.03	CHANGED	phhp-IssIlup+slsPpTp+sassshIE+Ah.c-lphu..............................................lsss+oAKpQAL-lIKtLpc..hlPItRAcM+l+lshssctspthh...........................................................ctltshhp.ph..tpp-ptsstaphlshlpPsta+tlpphlppp	..............hh+-llslluppslNPp.T.c+Passsh..IE+Ah.c-l.+hs..................................................................................lcssKssK.pQAL-slKtLpp....h.lPIcRAcM+lclplPs.ph..s.p.p..hh...............................................................................................................................................................................................ppltphhp...hh........cppt....t.s.s..phph.......l.shlsPGhhcpl.-hlp...................................................................................	1	114	198	282
+9210	PF09378	HAS-barrel		HAS barrel domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	The HAS barrel is named after HerA-ATP Synthase. In ATP synthases, this domain is implicated in the assembly of the catalytic toroid and docking of accessory subunits, such as the subunit of the ATP synthase complex. Similar roles in docking of the functional partner, the NurA nuclease, and assembly of the HerA toroid complex appear likely for the HAS-barrel of the HerA family [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.93	0.72	-4.08	60	266	2012-10-02 13:55:04	2006-12-06 11:10:15	5	8	209	12	130	3149	1869	90.80	17	19.30	CHANGED	lGhllGssst.pshhhhlps.t...............plphG-hVphp.t................tppllGhlhslpp.................................s.hshlshs..........................clluplcp	..................lG.Vlussss.pththhhcs.................tsphGcaVhlptp................sspllGhlpslpp...............h.p..t...t.......t..sp.hthltht............................h.....h.........................................................................	0	46	82	110
+9211	PF09379	FERM_N		FERM N-terminal domain 	Bateman A	anon	Bateman A	Domain	This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.55	0.72	-3.93	30	3027	2012-10-03 10:59:06	2006-12-08 09:24:46	5	150	200	46	1524	2604	2	84.60	27	9.05	CHANGED	Vp.hLDss.hhphp.....lsspsp.GpplL-pVsp+l.slpEp-aFGLpa.....sps......sph...................................pWL-hs+plp+phsc...............ssshhlhFRlKFas	.......................................lhhh.Dsp......h..pht..............lp..tpsp.GppLh-..t....Vsp..+l......sL..h..E..p-.............YFGLta............cpp...................spt....................................................................................................................................pWL.-.sK.pl.p.cQ.hhp........................................................ssh.p.h..hF..plKFas................................................................................................	0	372	505	936
+9212	PF09380	FERM_C		FERM C-terminal PH-like domain	Bateman A	anon	Pfam-B_851 (release 2.1)	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.03	0.72	-3.77	62	2452	2012-10-04 00:02:25	2006-12-08 13:07:32	5	88	124	42	1204	2086	0	90.40	28	10.92	CHANGED	cpcssc..lh.LGlsstGlhla...csss+l...ptFsWscIp+lSFccK.................................................+Fhlcht............................................tppppphsFhhss..hcssK..tlW+hClppHp.......F..a...phpcpsps	.........................................................................................................................pcGsc..lhLGlsstGlhla................csp.p...+l.....tt..FsW.scIt..+l.Sa.cc.+.................................................pFhIc.lhs..................................................................pppp.ss.hsFhhss......hcssK..plW+hClppHs.......F..aphtp...........................................................	0	270	364	720
+9213	PF09381	Porin_OmpG		Outer membrane protein G (OmpG)	Mistry J	anon	pdb_2f1c	Family	Porins are channel proteins in the outer membrane of gram negative bacteria which mediate the uptake of molecules required for growth and survival.  Escherichia coli OmpG forms a 14 stranded beta-barrel and in contrast to most porins, appears to function as a monomer [1].  The central pore of OmpG is wider than other E. coli porins and it is speculated that it may form a non-specific channel for the transport of larger oligosaccharides [1].	25.00	25.00	46.20	45.70	21.90	19.60	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.21	0.70	-5.33	4	299	2012-10-03 17:14:37	2006-12-08 14:43:39	5	1	282	10	9	87	0	288.50	92	99.37	CHANGED	MKKLL.CTALVMCAGMACAQAEEKNDWHFNIGAMYEIENVEGYGEDMDGLAEPSVYFNAANGPWRISLAYYQEGPVDYSAGKRGTWFDRPELEVHYQFLESDDFSFGLTGGFRNYGYHYVDEPGKDTANMQRWKIAPDWDVKLTDDLRFNGWLSMYKFANDLNTTGYADTRVETETGLQYTFNETVALRVNYYLERGFNMDDSRNNGEFSTQEIRAYLPLTLGNHSVTPYTRIGLDRWSNWDWQDDIEREGHDFNRVGLFYGYDFQNGLSVSLEYAFEWQDHDEGDSDKFHYAGVGVNYSF	.................................MKKLLPCTALVMCAGMACAQAEE+.NDWHFNIGAMYEIENVEGYGEDMDGLAEPSV......YFNAANGPWRIuLAYYQ...E...G.P.VDYSAG.KRGTWFDRPELEVHYQFLEsDDFSFGLTGGFRNYGYH.YVDEPG..KD..TA...NMQRWKIAPDWDVKLTDDLRFNGWLSMYKFANDLNTTGYADTRVETETGLQYTFNETVALRVNYYLERGFNMDDSRNNGEFSTQEIRAYLPL.....TL.....G.N.H...SVTPYTRIGLDR.WSNWDWQDD.IEREGHDF.NRVGLFYGYDFQNGLSVSLEYAFEWQD.H.....DE...GDS..D.....KFHYAGVGVNYSF..............................	0	1	3	5
+9214	PF09382	RQC		RQC domain	Bateman A	anon	Pfam-B_571 (release 21.0)	Domain	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure.  The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.18	0.72	-4.32	174	3296	2012-10-04 14:01:12	2006-12-11 14:34:43	5	41	2926	9	924	2638	355	104.30	30	14.90	CHANGED	DsTptApclLSslh+h..........t..p....p..........a..Ghshlh-lLp.........................Gspsp+ltph....sa.cplssa..GlGc.chsppphpsllcpLlspGhL.....phshp......pas.sLplspp.u..cslLc..Gc....p..plhlphst	................................................DsTpcAppsLSslhRs.................sp.........+.........FGhshll-V.L+.........................G..s..p.s.p..+lpph.....sa..-p..L.ssaGlG.......+..-.....h...op..cc........hpsll+pLltt.Ghl.........p.shs.......pas..sLpL..Tct..u..+slL+.Gct..pl.ht...s.....................................	0	278	557	764
+9215	PF09383	NIL		NIL domain	Bateman A	anon	Pfam-B_524 (release 21.0)	Domain	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins. This domain is likely to act as a substrate binding domain. The domain has been named after a conserved sequence in some members of the family.	20.60	20.60	20.60	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.05	0.72	-4.41	184	4317	2009-01-15 18:05:59	2006-12-11 17:17:47	5	25	3162	22	702	2638	28	75.40	25	22.67	CHANGED	sstll+LpFsGpssppPllupls+ca....s.lssNILtGsl-plpstshGpLllpl......t..Gsppp..hppulpaLp.pps.lpl.Ell	...............................s...ll+LpFsG.p.s.ssp.Pllupls+ca....s.lssNILtusl-hlp.s..sshGtLllpl................................p..Gsppp..hptAlpaLp.pp.t.Vpl.Ell......................	0	181	399	562
+9216	PF09384	UTP15_C	U3_snoRNA_C;	UTP15 C terminal	Mistry J, Wood V	anon	Pfam-B_7112 (release 21.0)	Family	U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA [1]. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs) [2]. This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (Pfam:PF00400).	26.90	26.90	27.40	27.60	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.45	0.71	-4.51	40	321	2009-09-21 22:48:38	2006-12-12 09:50:17	5	11	278	0	219	324	1	147.80	28	28.41	CHANGED	+Gps...hhscp--hllppt..........ppp+lppa-+hLppF+aucALDssL.........tstpscsslollpELp+RG......sL+tALtsRDEtoLpslLpalh+pls-sRassllhcssssllDlYusslspSs..hlcchltpLpp+lpcElchppchhplpGMl-...hL	..................................t.phhspts-hl.lspt..........pcp+lp...ta-+tL+pF+........aucALDpsL................tspssphslollpELt+Ru......sL+sALsuRDEpsLpslL.palh.+pl.s..c...PRassllhsluthllD........l..Y..u..sh.l...sp.Ss.......hlcchh.hpLppplpcElchppphhphtGhl-hl...................................................................	0	77	122	179
+9217	PF09385	HisK_N		Histidine kinase N terminal	Mistry J	anon	pdb_1yku	Domain	This domain is found at the N terminal of sensor histidine kinase proteins.	24.40	24.40	24.90	26.60	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.62	0.71	-4.55	7	130	2009-01-15 18:05:59	2006-12-12 10:37:03	5	3	103	3	13	66	0	137.40	58	43.26	CHANGED	Mp...........sspphLssaLcpppcpFlpsW+p+llls-cD.a+-cllpNGptlhchhhphhpcphs.p...lp.lupKIApERh-AcsNIu-FVYNsNhGRpElhphlstlssshp-LpsllccINhhFD+hlYasVppYs-	..............................................MtVFPIDK..DIKElFCSHLKNNRHQFVENWKNKM.....IIS-KDPFK.EVVQNGEcLLEhIIELhME-KDIs..YLQPLCEKIAIERAGADANIGDFVYNANVGRNELFEAMC.....ELDVSAR..ELKPIM...spIHTCFDKLIYYTVLKYSE....	0	1	7	9
+9218	PF09386	ParD		Antitoxin ParD	Mistry J, Bateman A	anon	pdb_2an7	Domain	ParD is a plasmid anti-toxin than forms a ribbon-helix-helix DNA binding structure [1].  It stabilises plasmids by inhibiting ParE toxicity in cells that express ParD and ParE.  ParD forms a dimer and also regulates its own promoter (parDE).	22.80	22.80	23.30	23.50	22.30	22.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.65	0.72	-3.86	4	38	2012-10-02 18:44:02	2006-12-12 14:31:42	5	1	37	2	7	32	2	77.80	61	92.81	CHANGED	MSRLTIDITDQQHQSLKALAALQGKTIKQYALERLFPsDsDuDQAWQ-LKsLLGsRIu-GLAGKVSsKSlsEILsEELu	..MSRLTIDlT-QQHQSLKALAALQGKTIKQYALERLF...P..uDuDuDQAWpEL+sLLssRIppGLsGcVSsKSlscILDEELs.........................	0	1	6	6
+9219	PF09387	MRP		Mitochondrial RNA binding protein MRP	Mistry J	anon	pdb_2gid	Family	MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex.  The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilises them in an unfolded conformation suitable for RNA-RNA hybridisation.  Each MRP subunit adopts a 'whirly' transcription factor fold [1].	18.60	18.60	18.80	18.80	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.31	0.71	-4.58	11	164	2009-01-15 18:05:59	2006-12-12 15:52:17	5	4	50	14	43	134	1	157.00	29	36.07	CHANGED	suts.u-usustustusssuo....+ppssusppt.Rs...PAF-IsHhsc-csupGs.atlsVst+sshl.p.PsLD.+..Rp.pplDp.............Ncss.Qscu-R.sloVphpslasAphluVLcuRhsplcspsphhsAsFsPsspsYshctpl+psuop................psh-W.....oVcF-sthulhLc+FLppAL+.shGFucphs	.......................................................................tst...ttts.....t...t..p..........t.hpl.+.stps.s.u.........t...s......htt.h..........Ls.p......tss........................s....t.pu-h...h...h.t........ssa.sp.sthlptRhshhps.s....h.......ssphY.hctp.+...tst...................................................................................................sth.W.....hhphss.hhuhh..hhLppsL...........h...................................................................................	0	6	9	19
+9220	PF09388	SpoOE-like		Spo0E like sporulation regulatory protein	Mistry J	anon	pdb_2c0s	Family	Spore formation is an extreme response to starvation and can also be a component of disease transmission.  Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A.  Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation.  This is a family of Spo0E-like phosphatases.  The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure [1].	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.94	0.72	-4.44	47	988	2009-01-15 18:05:59	2006-12-12 16:44:01	5	4	287	3	195	665	0	44.70	32	66.69	CHANGED	pLhppIEp+Rcchlplstph.GlsspcslphSQELDpLlNpYp+hp	.............................LpppIEtpRccLh...p.l..s...pch...Gh..s.pp.cllphSQELDcLlNpa.ph.h............	0	68	144	154
+9222	PF09390	DUF1999		Protein of unknown function (DUF1999)	Mistry J	anon	pdb_2d4o	Family	This family contains a putative Fe-S binding reductase (Swiss:Q72J89) whose structure adopts an alpha and beta fold.	25.00	25.00	85.50	85.30	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.94	0.71	-4.88	3	18	2012-10-02 22:59:21	2006-12-13 11:24:32	5	1	18	2	12	18	1	148.80	53	97.85	CHANGED	M...RYRsFoEPDaEsLQALDLAtQRRssPtaDsLP-REpAGRLSoSLuALRFYERSGHSFVAEsEu-clpGalLAQuVWQGDRPsVLVRAllLs-upsEDstRGLLRAVVKSAYDAAVYEVHLPLsP...ELEAAARAEEA+LTG.sYAVpHLGTRAAoAPG++LtR	...............................M+aRsFsE.Dh-tLptL....................tGchssSLuALRFFsRTGHSFlAp.EG-cshGFsLAQAVWQG-tsTVLVsRl...-ups....t....-shcGLLRAVVKSAYDAGVYEVALpL-Pt.+t-LcpALcA-Gas.lushsLAVRVLGSRGtRuEsctVL.E.	0	3	7	12
+9223	PF09391	DUF2000		Protein of unknown function (DUF2000)	Mistry J	anon	pdb_2gax	Family	This is a family of proteins of unknown function. The structure of one of the proteins in this family has been shown to adopt an alpha beta fold.	25.00	25.00	26.20	30.30	20.70	17.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.37	0.71	-4.49	36	322	2012-10-02 19:40:38	2006-12-13 13:31:01	5	2	297	2	106	309	39	130.80	30	94.96	CHANGED	-sKhslllcc-LsshptLNVsAaLusGlus..stP-hlGpsYtDusGphahslht.PlllLpu.spspLppl+pculp+...slshssaopshhsTGpppspptshttsst--lchlGlALhGs+KhVcKlT+uhsLat	............pKhslllcpcLssh.thNssAhLuhulut........phP-llGp..s.htDusGpta.slht.Pl.lLpu.stptLppl+pcuhsp....slhhssFspth.ssss.pp.ptshtssstsslphlGlulhGs+KtVsKlstuhsLa........................	0	25	52	81
+9224	PF09392	MxiH		Type III secretion needle MxiH like	Mistry J	anon	pdb_2ca5	Family	Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens.  MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells [1].  Once inside, the effector proteins subvert normal cell function to aid infection.	27.40	27.40	27.60	27.90	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.90	0.72	-3.42	39	1127	2009-01-15 18:05:59	2006-12-13 14:16:18	5	1	510	43	74	367	1	79.00	20	87.18	CHANGED	lsthspthpssssst...............................................tpplppthpshptt...................................................ssP...pplhphQtplspaolhhslpopslpthppslpsll.ph	.............................................................hh..................................................................tlpt..tthtpts.......h......................................................................st.hs...s...P.....ptlhphQhsltpaolhhshpSsls+thpshlssll.p.h.......	0	17	35	50
+9225	PF09393	DUF2001		Protein of unknown function (DUF2001)	Mistry J	anon	pdb_2guj	Domain	This family includes phage-like element PBSX protein (Swiss:P54332) whose structure adopts a beta barrel flanked with alpha helical regions.	22.40	22.40	22.40	23.30	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.48	25	231	2012-10-01 22:58:23	2006-12-13 17:06:55	5	1	162	2	56	189	2	140.60	30	95.64	CHANGED	M......hcupcsIsGphGclal....cspphspspphpAclchsKp-lshhGcphsppKssGhcGoGolThY+VoShhhphhhchlKpGp-shFclhspLcDPsS.hGt..EclsLcssshDclslAsa-ss..-hlEEEsPFTF--a-ll-	..................................hhcupcslsGp.Gchal.....cspphtphpphEAclEhsKp-lplhGc.hhpspKs..sGhpGoGohThap.loShhtph.hhch.l..+p.G.....p.-.hF.sl.ssh-DPso...hGp...cplhLpsss.hD...s...hhlush-ss..-hlE.EEhsFTFpca-h.-.................................	0	24	47	50
+9226	PF09394	Inhibitor_I42	Chagasin_I42;	Chagasin family peptidase inhibitor I42	Mistry J, Bateman A	anon	2fo8	Domain	Chagasin is a cysteine peptidase inhibitor [1] which forms a beta barrel structure [2].	22.30	22.30	22.30	23.60	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.12	0.72	-3.65	103	354	2009-10-19 12:22:43	2006-12-13 17:26:24	5	19	270	16	162	332	18	92.20	23	51.54	CHANGED	lsl..phGp.phtlpLspNPo..TGYpWplpt........sshlpl..hss......pahss..t.ss......hlGuuGhph.aphpuhps....G....psplphhYtRsW-ssss...ppash.slpV	................plp.Gp.phhlpLsuNPo..........T.GYpWphps...........sssslph....hss....................pahss...s.ss.t........hlGu.u.Ghph.apapuhps.....G....psplphtYtRsW-ssst...pphshpl.l....................	0	55	103	136
+9228	PF09396	Thrombin_light		Thrombin light chain	Mistry J	anon	pdb_2b5t	Domain	Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.	20.60	20.60	20.80	22.20	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.62	0.72	-4.35	13	80	2009-01-15 18:05:59	2006-12-14 17:18:55	5	8	46	403	27	111	1	47.70	64	8.36	CHANGED	TshspacoFFss+TFGsGEADCGlRPLFEKKslpDpoE+ELL-SYhpGR	....Tsss-apsFFs.+TFGs....GEADCGLRPLFEKKslcD+oE+ELL-SYh-GR...	1	1	3	10
+9229	PF09397	Ftsk_gamma		Ftsk gamma domain	Mistry J	anon	pdb_2j5p	Domain	This domain directs oriented DNA translocation and forms a winged helix structure [1].  Mutated proteins with substitutions in the FtsK gamma DNA-recognition helix are impaired in DNA binding [1].	25.10	25.10	25.40	25.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.10	0.72	-4.26	130	5039	2012-10-04 14:01:12	2006-12-15 16:44:09	5	23	4114	16	987	4009	1919	66.30	43	7.56	CHANGED	ssp.ppDsLa--AlplVlcpppASsShlQR+hRIGYNRAARLl-pMEppGlVushpus.tsR-VLh....tp	..................s.tptDsLa-cAsph.Vl....c...p..p..+....ASsShlQR+h+IGYNRAARll-phEppGlVust.p.u.s.tsR-VLh..t..............	0	318	635	820
+9230	PF09398	FOP_dimer		FOP N terminal dimerisation domain	Mistry J	anon	pdb_2d68	Domain	Fibroblast growth factor receptor 1 (FGFR1) oncogene partner (FOP) is a centrosomal protein that is involved in anchoring microtubules to subcellular structures.  This domain includes a Lis-homology motif.  It forms an alpha helical bundle and is involved in dimerisation [1].	29.40	29.40	29.40	29.40	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.85	0.72	-3.99	6	189	2009-01-15 18:05:59	2006-12-18 11:26:16	5	6	93	2	120	199	3	75.50	35	27.53	CHANGED	K.oPLsNENLKKhlsT+-...GRLVAsLlpEFLpFFpLDFTlAVFpPEuuh.pshpsRpsLuK-LsIs-u-ssKssPLLhEll++	..................................p...shLlspLlpEaLpF.phcaThuVap....sEo..up..s.p.s...........s....Rp.Luc-Lslh-.....s..pt...s.ss..h..PLLhtllt.................................	0	50	60	86
+9231	PF09399	SARS_lipid_bind		SARS lipid binding protein	Mistry J	anon	pdb_2cme	Family	This is a family of proteins found in SARS coronavirus.  The protein has a novel fold which forms a dimeric tent-like beta structure with an amphipathic surface, and a central hydrophobic cavity that binds lipid molecules [1]. This cavity is likely to be involved in membrane attachment [1].	25.00	25.00	197.30	197.10	19.70	15.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.42	0.72	-3.95	4	60	2009-01-15 18:05:59	2006-12-18 11:57:56	5	1	59	8	0	23	0	97.70	94	100.00	CHANGED	MDP.KTNVVPPALHLVDPQIQLTITRMEDAVVHGQNNADPKVYPIILRLGSQLSLSMsRRNLDSLEARsFQSTPIVVcMTKLATTEELPDEFVVVTAK	MDPNQTNVVPPALHLVDPQIQLTITRMEDAMGQGQNSADPKVYPIILRLGSQLSLSMARRNLDSLEARAFQSTPIVVQMTKLATTEELPDEFVVVTAK	0	0	0	0
+9232	PF09400	DUF2002		Protein of unknown function (DUF2002)	Mistry J	anon	pdb_2g7j	Family	This is a family of putative cytoplasmic proteins.  The structure of these proteins form an antiparallel beta and sheet and contain some alpha helical regions.	19.70	19.70	20.40	26.20	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.49	0.72	-4.34	4	520	2009-01-15 18:05:59	2006-12-18 12:57:38	5	2	516	1	30	104	2	111.10	86	97.78	CHANGED	MYLRPDEVARVLEpsGFphDhVTscuYGYR+GEpYVYVNREARMGRTALlIHPsLK-+SssLApPsSsIKTss+Y.pFPLYLuG.thpE+YGIPHGFSSR.uLppaltphF.....c	.........................MYLRPDEVARVLEKVGFTVDVVTQKAYGYRRGENYVYVNREARMGRTALVIHPTLKERSSoL.....AEPASDIKTCDHYQQFPLYLAG..EpHEHYGIPHGFSSRlALERYLNGLF.GE...............	0	1	4	17
+9233	PF09401	NSP10		RNA synthesis protein NSP10	Mistry J	anon	pdb_2fyg	Family	Non-structural protein 10 (NSP10) is involved in RNA synthesis. it is synthesised as a polyprotein whose cleavage generates many non-structural proteins.  NSP10 contains two zinc binding motifs and forms two anti-parallel helices which are stacked against an irregular beta sheet [1].\	  A cluster of basic residues on the protein surface suggests a nucleic acid-binding function.	21.50	21.50	22.10	38.80	20.00	21.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.64	0.71	-4.39	11	653	2009-01-15 18:05:59	2006-12-18 16:29:24	5	34	206	53	0	662	0	121.00	53	2.47	CHANGED	ssNSslLolCuFuVDPupsYlDhVpsGupPlsNCVKMLss+oGsGhAITssP-AshsQ-oYGGASlClYCRsHl-HPshsGhC+hKGKaVQVPh.sspDPltFsLcNsVCsVCGhWhsaGCsCDt	....ssNSulLSlCAFAVDPAKsYhDalssGspPlsNCVKMLssHsGoGhAITssP-ushsQ-SaGGASsClYCRs.Hl-HP....s.hcGhCchKGKaVQlPo.stpDPVuFsLcNcVCsVCGhWhsaGCsCDt...	0	0	0	0
+9234	PF09402	MSC	MAN1_C;	Man1-Src1p-C-terminal domain	Mistry J	anon	pdb_2ch0	Domain	MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation.  The C terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad [1]. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands [2].	21.70	21.70	22.00	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.04	0.70	-5.73	37	386	2009-01-15 18:05:59	2006-12-20 11:29:55	5	12	255	1	248	363	1	257.20	21	43.10	CHANGED	hLlhshhlha.....shaatppphtlGaCupsh.st....................................................C..CP.puhCh...plpCctsahht...h..................sspCh.Dsc+tphlptl..hcthhchL+p+suphcC.G................t.psshssslsts-..........................ltchltppp....hhstppF-p.hapsslttlpcp....-lhhp.......................................................................spthhhusohsplslpC..thppplpphlh..........chthhlhslhlhhhsh...hhl+hthppcppcptplppllppslcpLppptt...........t.spsppsalslspLRDp.....lltsptphp........ppplWp+lhphl.-p.susVcsphtE.htG-hh+sWEWlssh	..............................................................................................................................................................................h.............................................................................................................................................................................................................................................h........ctpttthhptl...pphhphLtpptuphpC.G.............................t..p.tls.t-..........................htphltp.p..........tp...hpp.haptsl.t..lhpp...........t-lh.ht........................................................................t..s.sp.hhhhp.sshsphshtC..thpp.th...hthht...............phhhh..hhslhhh.h.hhh.......hhhc.hphp.pt....cppptth.p....hlppll...chLpsptt.................t.s..tt.psalslsplRDp.....ll.sp.pchp.........................................hpplWp+shphl..tt.poplpsp.pc..hsGc.hhsWcWhts.s........................................................................................	0	80	125	192
+9235	PF09403	FadA		Adhesion protein FadA	Mistry J	anon	pdb_2avr	Family	FadA (Fusobacterium adhesin A) is an adhesin which forms two alpha helices.	25.70	25.70	26.00	25.70	24.70	25.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.63	0.71	-4.12	3	115	2009-01-15 18:05:59	2006-12-20 11:44:49	5	2	30	9	12	93	0	119.50	35	97.25	CHANGED	MK.KhLLhuhLlLSuhSaAA--......AtpllSELKuL-AEYQsLspcEEARFpEEKppuEsAcppltcLcElpsulEE+lt+LpEEuKTRFaKDpYccLhK+Y--YLsKLEpKIs-pcplIS-FEKIQclR	...................................MK.K..hl..Lh..s.hLlluuhuaAAps...............stplhuE..lpsl-AEYQpLhpcEptRhpE.+ppt-...shcppltp.cph.tphpchht+Lpp-.uchRaa+..cpYpcLh.K+ac-hhpcLEpchtcpcphIsphpKl.tlh...............	0	6	11	12
+9236	PF09404	DUF2003		Eukaryotic protein of unknown function (DUF2003)	Mistry J	anon	manual	Family	This is a family of proteins of unknown function which adopt an alpha helical and beta sheet structure.	19.80	19.80	21.60	20.30	19.10	19.00	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.44	0.70	-6.07	3	98	2012-09-27 07:58:09	2006-12-20 14:16:26	5	7	69	1	71	99	0	328.40	41	81.61	CHANGED	MsDs...EELRPVP+ERAVLESFFTQLGMFSFDRAKDYVEKEKDASKSAGAIWuSLLAALAHLAAAEKlYHNMTFLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVoMGRsAPGGSAPsLEELLPHLSEQLCHFlQARMEIADFYEKMHoLGSQKoINSEELVoTLDoIL+KYSSRFHHPILSRLESSFQlEVDVLTQLLRCQAQISEW+FLPSLLoLHGAHSKLQoWGQlFERQRETRKHLFGGQSQKAVQPPHLFLWLQRLQAsLLAKFSFYFHEALSRQTosSEMKALTARTuPDYFGKISSFIRKYDASNVSLVFDNRGSESFQGHGYHHPHSYREAPKGVDQFPAVVSLPSGERPVTHWPNVIMIMoDRAoELNTLEKVVHFYDDKVQSTYFLoRPEPHFTIVVIFDGRKSERDSaIlAFLQELsGSLRNSKPFoSLKPGSKG	.............................................................................................................................hh.th..hs.hcp.Yhph.ah..c.....hht+.pp.o.hh...YpsLhsph...pph.t...................................t.......p......hhsplspQLs.FhpARh-hhshYcp.hhshu.sp..p..h..s.ccLlshL-slhcpasp+hpHs..hLp...lcsuhphElslLtpLL+sQsplscacFLs.oLlsLasA+.....s+Lp..sWs.p.h...h....p.pp..ppo..pK..phFuu..pspKs......sp....sP.pLahWL.+hpshLLuKFShYFH-sLSp...Q.....so......s....u..-.M.K.slsu+s....ss.Dhhs....+IpuFhRKhD.u..slsLla....Ds..+u.s....-.s..ap.upGYpaPpp..p-sPp.....G..l.cpaPslhohP.s...p.......p.Ph...HhPNllhl......ht-pt..s-Lss.h.-+llaahD....s.+.lps.................TY...alsps-sphhlV.lIac.s.p+.p-+DphhhsFlp-ls.tL+ssKhht.L+..........................	0	31	36	54
+9237	PF09405	Btz		CASC3/Barentsz eIF4AIII binding	Mistry J	anon	pdb_2jou	Domain	This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz).  CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa.  The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [1][2].	20.80	20.80	21.50	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.24	0.71	-4.10	21	266	2009-01-15 18:05:59	2006-12-21 09:49:36	5	7	179	10	185	259	0	121.40	24	19.09	CHANGED	sssssppsup.sst..tt...t..pptccp-pcchcc-ccpsPs..aVPsRGsFFhHDcRss-sssssh+................R.hu......................h...s.h..................t+phpssutpspWsHDha-phss-psPpsp.phhsthshshpspss	........................................................................tts................t..t..tp..........tttcct..t..p.c.ttpccccpsPt..alPp+GsFahHDc.Rtp.sst...p...th+....................pstG.......................................h........................................t+thpsss....t.ttpWpHDpacp...pc..ptsppptphht..t........tt..........................................................	0	52	87	143
+9238	PF09406	DUF2004		Protein of unknown function (DUF2004)	Mistry J	anon	pdb_2aby	Family	This is a family of proteins with unknown function.  The structure of one of the proteins in this family has revealed a novel alpha-beta fold [1].	22.40	22.40	22.90	24.00	21.20	20.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.17	0.72	-3.98	22	148	2009-09-10 18:54:03	2006-12-21 10:54:57	5	1	128	1	20	117	5	99.60	26	66.38	CHANGED	phpcpAcpAltshhpsc........ppahpaHl--httchh..hh...t...sshpphlctlpltths.a.p.tst....hhhhDathss-.hoD.llsVpFcppGclhp.lsaES	..................................p.htppA+pAlhp.hcp-........shYh-FHt--hspphh...h...........shpphlctl..pLttls.ahs..pst.pp.shs...hDaphss-..oDElLsV+acpcGclhp.lsaES...	1	7	14	17
+9239	PF09407	DUF2005		Protein of unknown function (DUF2005)	Mistry J	anon	pdb_1zel	Family	This is a family of proteins with unknown function.	25.00	25.00	56.60	32.70	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.10	0.70	-5.67	2	47	2009-01-15 18:05:59	2006-12-21 11:07:22	5	2	45	2	3	12	0	279.90	91	99.00	CHANGED	M....................VSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPL.RVIGKA	..............................hlSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEA...AISDPYLPLRSWLA.RDQNAGFMLAGA..SAAWHLGYLDRQPDG.RIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA.....................................	0	2	3	3
+9240	PF09408	Spike_rec_bind		Spike receptor binding domain	Mistry J	anon	pdb_2dd8	Domain	Spike is an envelope glycoprotein which aids viral entry into the host cell.  This domain corresponds is the immunogenic receptor binding domain of the protein which binds to angiotensin-converting enzyme 2 (ACE2) [1].	25.80	25.80	26.00	26.50	22.00	25.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.56	0.70	-4.83	11	626	2009-09-14 15:17:47	2006-12-21 12:06:25	5	3	218	29	0	442	0	166.60	48	21.86	CHANGED	PNLPD.CsIEcWLsApoVPSPLNWER+pFSNCNFNhSoLhpalQA-SFoCNNIDASKlYGhCFuSlolDKFAIPsSRplDLQlGsSGaLQohNYKIDTsuTSCQLYYSLPtsNVTls...NaNPSSW.............................NRRYGFNshshht......hspHDVVYuppCFssssoaCPCtpss.......hhusCls.........spssousC.PsGTphhpC.tthshsh..........tCcCsCsPcPhs	............................t.C.ht.hhss.....PpshsWcRhhhpsCshshs.lhp..h.htph.C.shs.s+l.s.Catsl.hD.Fhh.tt...........................................................t.h..........................................................s..........sh.psps........hGhhspHDVVYApcCFp.....APssaCPCKLsu.........u...hCVs.s......hppTGhGsC.PsGTsY..hsCapts.................sDslssPcshp...............................................................................................................	0	0	0	0
+9241	PF09409	PUB		PUB domain	Mistry J	anon	pdb_2cm0	Domain	The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain [1]. This domain is also found on other proteins linked to the ubiquitin-proteasome system.	20.30	20.30	20.30	20.30	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.79	0.72	-4.22	76	656	2009-01-15 18:05:59	2006-12-21 13:09:37	5	60	181	5	451	632	8	85.50	22	15.60	CHANGED	pshcphtpslphLh.cllpNIlppPsctKaRpl+hsNpshppplhsh.ps....uhplL.phhGFpppt.........pthhhhs...tts.......shttlpphhpt.......L	..............................t...tthtpuhphLh.phlsNll...p.....p..P......p..-......p...KaRpI+hsN.tsFppcltsl.pG......uh-hL.pthGFpct.................pphhhhs.....t..........p...........hh..........................................	2	189	262	372
+9243	PF09411	PagL		Lipid A 3-O-deacylase (PagL)	Mistry J	anon	pdb_2erv	Family	PagL is an outer membrane protein with lipid A 3-O-deacylase activity. It forms an 8 stranded beta barrel structure [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.81	0.71	-4.07	51	691	2012-10-03 17:14:37	2006-12-21 16:16:45	5	3	608	2	225	817	917	139.70	20	62.70	CHANGED	sssshpshplshpashsh.......phtttplphhh-sshshhp.....sst........ssth.hGhssh.hpaphss.t.....halEsGlGsthhspsphs......................t.phuotFpFpsplGhGhpassst......pluhRapHhSNAGlp.p.PNsGlsthslhhuhsF	..................................................................................................s......h.h.h.ht...........p..hhth.t..h..ch.shs.hhp......sst.............ts.h.hG..hs.h..hth.hhtt......hah..phG.hG.st...hhspspss......................thp..l.uos.a.p..F......tpp..hul..G..hpasst........psuhphpHhSNuul....p.p.sNsGhN.h.h.shpluhsa............................	0	59	132	186
+9244	PF09412	XendoU		Endoribonuclease XendoU	Mistry J	anon	pdb_2c1w	Family	This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.	25.00	25.00	29.60	29.40	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.80	0.70	-5.35	40	279	2009-01-15 18:05:59	2006-12-22 09:55:27	5	13	125	3	203	282	1	246.00	34	69.40	CHANGED	stsss-lpslsppLWshD....sN+h.............sutca.plshQsptsshsp.....sDt.AspsLFshVs-shhp..pP....TautahsLlDNYphssG.....hsE.plTsp..EppEppsFL-tlh.pTslM+hhapaLhpKsh.......ssss.psF+.phLpplWFphYsRssut......h-.SSGFEHVFVGEhK.s..........sclpGhHNWlpFYlpE..+pGp......lDYpGYhhctpts...s........lLslQFpWs..........ul.hKsluShFlGsSPEFElALYTlCFlsssc......cp.splplus..hplsIhs..aphtpps.......IGouYP	...........................................tp-lpplsppLaphD.....Nph.................tpph.hlshQsphps..tp......tDt.usps.LFshVspphhp..ps....TatthhsLhcN..Yphs.su.....hsE..hho.sp..chpEpssFLctlh.pTslM+......hapaLhpKsh.......h.ss.p.pF+.p.Lppl.WFshYuRspsp.......s.SSGFEHVFl.GEhK..s..............scl...GhHNWlpFYhpE.......cpGp......lDYhGahhctphsp..sp..........llslpFsWp...........uh.hK.luo..hFlGsSPEFEhALYTlCFlspsp........ct..spl..plss.....h.htlhsaphttpt.......Iuoua...................................	0	77	101	166
+9245	PF09413	DUF2007		Domain of unknown function (DUF2007)	Mistry J, Bateman A	anon	pdb_2hfv	Domain	This is a family of proteins with unknown function.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-9.00	0.72	-4.15	90	1038	2012-10-01 21:59:08	2006-12-22 11:53:11	5	11	859	1	319	859	252	65.90	22	55.22	CHANGED	hclhpsss....lpsphlpslLcpsGItshlpspt.huuh.........s...us.sh..hclhVtc.cDhccAppllpchpt	..................h..lhpsss....hcAphlpslLcspGItshl..p....spt.hssh...........h.....ss.uh.....hclhVt-.cchppAppllpph..t.................	0	106	212	273
+9246	PF09414	RNA_ligase		RNA ligase	Mistry J, Coggill P	anon	pdb_2hvq	Family	This is a family of RNA ligases. The enzyme repairs RNA strand breaks in nicked DNA:RNA and RNA:RNA but not in DNA:DNA duplexes.	20.90	20.90	21.00	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.53	0.71	-4.50	22	428	2012-10-02 00:43:09	2006-12-22 12:03:17	5	5	363	7	118	450	40	184.40	19	55.28	CHANGED	p-aVsoEKlHGsshslhh.tttp.........hphstpos.............thp..................hhstatpslpshphhhc..ht..h.......stslhlhGElhG.............Pslpttsh....................t......chcFasFclhh....tp.t......phhs.cthpthspphslt....hsPhLscGshsthhhhss......................................................................h..shtt.slsEGlVl+sst...........ststshlKh+	.........................................................hlhpEKlDGsNhs.l.hh..t....................hthhtRsp.........................ht.....................................................................tpsta...ttt.hpthhthhp...t...................htshhla.GEhhhhh.................pul.phpth..........................................................................cpcFa.lFslhsp.......stt.........taLs.h-..ps.phhsphhs...l......h....VP...h..lh...ts.t.h..s....h.tthph..thh......................................h..shts.sh.t..EGlVh+stt........t.........h......................................................................................................	2	55	89	107
+9247	PF09415	CENP-X	DUF2008;	CENP-S associating Centromere protein X	Mistry J, Wood V	anon	manual	Family	The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.	25.00	25.00	26.10	25.50	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.38	0.72	-4.16	24	170	2009-11-05 17:40:01	2007-01-02 12:50:08	5	1	155	12	127	175	0	73.10	33	50.36	CHANGED	stphlsRllp.p.Fcs.ppT+Isp-AhpllscYlclFVcEAltRut......pcsputpp...........lchpcLE+.lssQLlLDh	.................chls+lLp...t.Fps..ccT+ls..p-..AlplsucalclFVpEA.ltRust.......tpscsttt...................................l-l-cLE+.lhPQLLLDF..................................	0	33	66	104
+9248	PF09416	UPF1_Zn_bind		RNA helicase (UPF2 interacting domain)	Mistry J	anon	pdb_2iYK	Domain	UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation.  This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [1].	25.00	25.00	25.50	29.80	23.20	22.30	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.12	0.71	-4.63	16	324	2009-01-15 18:05:59	2007-01-04 16:32:50	5	7	266	6	238	323	3	142.70	57	14.31	CHANGED	HACAYCGIcsPssVlKC...sCsKWFCNu+ssT.uuSHIVsHLV+S+H+pVsLHs-SsLGDTsLECYNCGs+NVFlLGFlsAK.sEsVVVLLCRpPCA..pt.+DhNWDsspWpPLI-..-RphLSWlspsPS-p-..h+AR.IT.pQIs+LEphW+sN	.......................HAC.uYCGIHsPusVVpCs..sCpKWFCNu....R.G....sT.SuSHIVNHLVRA+HKEVpL.....H.-usL...G-TlLEC.YNCGs+NVFlLGFIPAK..uD.oVVVLLCRpPC......A.s..s.u.KDhN.WDsop...W.QPLIp..DRsFLsWLVp.hPS-.pE.QLR.AR...pl.ospQIsKLEEhWKpN.......................................................	0	88	129	199
+9250	PF09418	DUF2009		Protein of unknown function (DUF2009)	Mistry J, Wood V	anon	Pfam-B_18128 (release 21.0)	Family	This is a eukaryotic family of proteins with unknown function.	25.00	25.00	49.70	25.80	18.10	21.80	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.45	0.70	-5.71	11	144	2009-01-15 18:05:59	2007-01-05 15:47:23	5	7	77	0	106	145	11	364.20	38	78.36	CHANGED	c+A+YIPlRLo.-ERKlLRLLEAALpVS-YTD+VDllSh.pS+sKRlspQLKEhCulLsGLlVA.DhKtGpcLlcpK-FsspAcaFQslFEIGRRYKlMNP-+MRosYGKlhYMlQDSh.s-lpc.tLGFslhKPIhTVapaLppps......uhslLpDshl.hAhscl.P.sKsRsplp+tI+pKEpAlEpLu++YSs..uthscE-lc.slYSluDtNualptNR-Plp+MLphLcpaFsPssspch.asLuIphGtsGARLoHsHc+QaaYVhQSLoLWppIh+-MFpLWhlA-tDLhsssp.YcLssTGQGLNRlQtCPslh+AhcplLpcspccht.sWVGSSVlHLGDcsVPNALaFIDKYsQVsRILIPllpsltpIcsL.csDtplhsYIcppaGusppL++sILpDFF+HuFDGSGuDNaaDAGSCIDGRLTSAWNWsNpIpKKpYYsIFLhoGFouF-G	...............................................spalPlRLs.pERphLcLl-us................LpVS-YTD+lD.h.p.........h...h..................s.psp+hhtplcchhshlsGLhlut.....sh....c.Gpp.lhp.p.+s.htt..t.phhpphFEluRRaKhhNPpphRspYGKhhahl.Du...pltc....hlta...p..hhpslpTVhthLp.ptt......s.thlp.D.hl.hsh......l...........................lpp.lptKct..uhptl.pcYss..pthpp-plcpslhSlsD.psalt.NppPhpphlphLppaa......pPtp..p........t........hoLuIp....................Gt......sGuRLoHsHppQa.YVhQSLhLWppl.ppMhpLW.hu-pD.hL.ss.pt.YpLhsTGQGlpRhptsPph.phMppllppsppph.s..tWVGSsllHLGDcsVPNuLhFIDKYsQls+IL.Plh.sltpl.pl...........p..p......t................httalpptauuhpphphhILtDFF+HuFDGSGuDNh..uGSCIDGRLTSAWNWCsplp+K.aashFhhsGF.GF-G...............................	0	59	79	102
+9251	PF09419	PGP_phosphatase	DUF2010;	Mitochondrial PGP phosphatase	Mistry J, Wood V	anon	Pfam-B_22310 (release 21.0)	Family	This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.90	0.71	-4.90	16	326	2012-10-03 04:19:28	2007-01-09 14:34:34	5	8	304	0	187	825	133	152.60	27	70.39	CHANGED	lsu.slslhpLlhsPSLhlPHlsVsoFspLPhsl..................hppssI+AVVLDKDNChshPccsclassYpcphccL+.........psasst.plLIVSNoAGosc.DhstptActlE+soG..lsVLRHs.........hKKP..GCtcElhsYF+pp.h..lppscElAVVGDRLhTDllhANhMGuauVWlp-GVp	............................................................................................................thhhPphhl.........s.sltpl..shth...........................LpptuI+ullhDhDNs....Ls..ppsplhs..p..hh....ph.hcch+...................pt.hst..tlhIVSNss...........st..ppsp..tlp...pths.............l..slt.as......................sK.KP....ts...h...p...cl.hp.hh.....t..tp.........................t.........s.pclslVGDRlhTDllhuNh..h.G.aslh......h................................................	0	72	121	162
+9252	PF09420	Nop16		Ribosome biogenesis protein Nop16	Mistry J, Wood V	anon	Pfam-B_6406 (release 21.0)	Family	Nop16 is a protein involved in ribosome biogenesis.	25.00	25.00	27.70	28.50	21.10	22.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.15	0.71	-4.14	45	332	2009-01-15 18:05:59	2007-01-10 16:36:55	5	4	279	0	223	301	1	178.70	25	84.52	CHANGED	lR++++s+uuhs+ss++pts+p..t...+plsh.s..sslI.......tp...sWDcptTlsQNYp+LGLsschstss........................................................shtph..spscltRDspss.l..h.....................................................................pttpspllppLEc.......App.s.....+pt+phSccE..pcalppLlcKHG.-DacAMthD+KLNhhQpotupl+...R+lp+app	.......................................................................................................................................................................+p+p+ppp.thpss.p+ph.p+p............+thshht...sshl.........tp......sWDcptolpQNapchGLssc.Ntss..........................................................................................s.ppht.tphc.lpp-.....tps.t.........................................................................................thppspVlppLEp........p.Ast.p............+ptpphSccphcalppLlcKHG....-D...YcAMspDcK.N.hQpT.tpl+++lppah.t............................	0	77	120	183
+9253	PF09421	FRQ		Frequency clock protein	Bateman A	anon	Griffiths-Jones S	Family	The frequency clock protein, is the central component of the frq-based circadian negative feedback loop, regulates various aspects of the circadian clock in Neurospora crassa [2]. This protein has been shown to interact with itself via a coiled-coil [2].	22.40	22.40	22.60	25.60	20.30	22.30	hmmbuild  -o /dev/null HMM SEED	989	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.00	0.70	-13.94	0.70	-6.78	4	63	2009-09-11 06:31:12	2007-01-17 12:55:18	5	3	35	0	55	66	0	625.70	32	95.98	CHANGED	RssPhsSpGHPLPRRsSP-pSlTL+pHRLARDAS...lpuShhusssspsQ.sSSssRRsSSGESp-TGQSDsppWFsQSNpNPsAsF..-SNhM-VDPPFYQKEoDSSNE-u+hP.ttsPs........shh+sosAHSSSADDYRSVIDDLTVE.pRLKEELKRYKQFGSDhMRKEKLFEIKVHGLP+RKKRELEATLR-FAASL.GsSSp..SoSpR...+KsuRHusts+....SuusShSKHsSSSS.S+SRPVDSAYASMSTG.....spSSGsSLsRPShouttpTupQKVEsYLRDhP-GLhP+HllMT-KEKKKLVVRRLEQlFTGKIuG+phpRspo..hPuhsuuLss..............pGpthu..pPPs..............EshREApI..Q-sp.sc...KpppS+DssSASNSstDQTEsGGsssuSGsGssSG....sNTSPPhs.sP-QRPTRPRDLDPDRlQIPSENM-YIRHLGLVsPEhLpsSpsphp.DVAPDAEGWVYLNLLCNLAQLHhlNVTPsFIRpAVsEKSTKFQLSsDGRKIRWRGGTDGTKFSSDSStDpSQpSPhTDDTEDuSsKNG+RKKpKsppAcSphuphs.S+..........usSDoFHYKPhFlHppuSStETSLE-u..uS.Gs...l-ESs.usS+WshSGSGsTpQRRKRRhDGAIVYYoGAPFCTDLSGDPGDh.........SPss.MpuutctcusupG.........ctschV..RohSGSSLshRPLSDs+hpluph.cFsPtN.....P-LVsDsGspssD.-h.FPWs--PthlcVpPL.....EPSGLGGVLPDDHFhllVTTRR...shRPs.ppp.LuRopoSE..-Ts-hIspRLAohpTS.....PhP.Pps++Lss....u.lpIEYlSGch+RLNPssLPPPAIFaPPFSoDSSasstDDLuSDs-.....-E-s.SEt.MSRRANPH.SDNp.Y.ccsDLu.ssEss.c.Ds-.......cDhchuuDpGts.RuhhspscuVcGsupPhusssG+-sshh+TGSSsATAGGsESGYSSShE-	......................................................................................................................................tt.st......sp...s.pWappss.psh.......t.h-........p.s...pps.p..p........pt....t...........................................................sp.usss--aRSlIDDLTl-.ppL+pcL++Ycp..ss.shhcc-KLFEl+haGLPtcK++ELEthLRpFsssh..t...s.t........s.....t.........tt..............ptts.Ss.......-SuYsShS.t.u.....stsptss......t....h..t.......p..t.tphpsaLp-hPtGLhP..p...h.ho-+p+KphlV+RLEQlFsGc........t.....................................................................Es.+EAph..................t......................................................................scQRPTp.hDlD..R.......hpYhppLsh.s.p..................cGWl.LNLlhshAQLHhhsVsstFl+pAl.thSs+hplS.DGpKlRW+GG.psTphSup...u.....ttts....tp..h....t.tt.tphppt......t.t.....t........s...t....t..................................................ptFhYcPhFhp.....sst......ss....-tt....S..s............pps....st.st..hs.sh...t..........p.pp.-GshhaYsss.FChDLSGD..hsh.........p..ss...h..st.p................................ps.SGo.....h.hp.Phsp.......................t..........sp..t.......p....hspt..t.......t.......h......ssGlGGV.PtDpFhhhV.o++...............................t........................t..p.......l..pth...sth..ps.............................lph-hhohphp.L.PssLP.Ps.ah..as.ssp..t....s...p..s.........................................................................................................................................................................................................................................................................	0	8	23	51
+9254	PF09422	WTX		WTX protein	Bateman A	anon	Bateman A	Family	The WTX protein is found to be inactivated in one third of Wilms tumours [1]. The WTX protein is functionally uncharacterised.	21.20	21.20	21.40	21.80	20.20	21.10	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.70	0.70	-5.53	9	168	2009-01-15 18:05:59	2007-01-17 13:40:10	5	3	40	0	96	163	0	267.30	25	53.70	CHANGED	psls+SKTHDGL...........pctspususssphssstShsssP.....s.t..sspShstuhsFhShl++uutppsttu.....phuhs+pK+GLKGlFSShRh+RKsK.ttt-.p.s..pt.ttshhhstp.suSh.pl.......E...pshcc................susc.sssssppsPupspstsssPstsspp.usth.sstsh.ts-u.hps..st.tth..s................................uss-PPu-PSsDpLCh.hFsDVTSLKSFDSLTGCGDIIAD.-.-...GsSsssp..............................................hsusGptssu....thcpsuslVsYQGGGEEMASP-psD......................-s-hpchW-hlspo--pppt............s..hPths.....p.hh..uspssc.....+c.splcsttLtclPl.........ppt.p.t.tsPps-ptEusPsSDEGYaD..SsTPG.E--s...uu.s..p+sslPRDShSGDALY-LY.DP--u.....httusp-ssslSph+shSt.hhs.Ph	..............................................h.pspoh-sh.......................................t...........................tph...h.....................t...t......................sh.+.t+sh+shFp.h+.ppp.....................................................................................................................................................................................................................................TGCG-lhA-...........S..hs...................................................t.t....t......pptsshsshQGusEphA.Ptt.-...................t......tt...ht....t.....t........................................................s..t.............s..t...h.......................t..pp..Es.ssSDEGYaD..ShoPs.p.-t...........t.hhsRDShSGDtLY-ha.-Ppt..................................h................................	0	4	8	30
+9255	PF09423	PhoD		PhoD-like phosphatase	Bateman A	anon	Prosite	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.82	0.70	-5.92	148	1704	2012-10-02 19:15:56	2007-01-23 14:55:29	5	31	861	2	812	2178	650	392.20	20	71.03	CHANGED	hGVASGDPtsDulll................................WTR...lss..............................s.......slsVpaElA...s.........DtsFp.........p..lVppGss.hsssc..hDaoV+..........................V-lsG................LpPsppYaYRFp...s...........stSssGRsRTs....sssthpp....l+hAhsSCssa............pGa...................assYcphAp....p.s...hDhVlHLGDYIYEh.............t.t.h....sppth.p......t...t-.................hhTLsDYRtR....auhY+sDssLpuhHA....phPalssWDDHElsNNhh...tsusp..................ttsattR+ssAhpAYaEahPl............R...........tss.s.....................hp.l..........YRphpaGsLsclhhLDTRpa+s..........................................spsh.h....................................................................t.h...........................s....ssRolLGtpQppWLhppLt.......sSp...upWpllupQlhhuphshss..........................................................t.shshDsWD...........GY.spRpclLpth...p....pt.slpNsVhLoGDsHpsaAs-lpss...............ttt..p.s....lusEFsssS....loSsuh....................hst.lhst.sPclpahshsp...............RGYs........plc..hsspphpsca	..................................................................................................................................................................................................................................................................h.hth..................t.....t............................................h................h..............t.....s..a.ss...p..........................htht.s................L..ss.p.h..h.Y...p.h.h.................................s.....h....G........p......hp...Th.......stt...tp...................hphsh...sSCt...t..h.............t..uh....................................................................hpha.p.p..hsp....................p......Dh.hlahGDhlYt.s...............................h........................................................................h..s..l...t.c.....Y.R.....tp........a.t.....h.h..........t....c......s.......s.......lp...t...h.p..u.............phP..h........l.h..hW.........DDH.........E.l.t.sshh........ttt..................................................tsh...t...t.h.t..t..s...AhpAa..h...E...a..h..Ph...........................................................c.................t...p............................................hpl.......a..c....p....h....p.....a.....G....s....h.....h....p....lh..h.LDsRpaRs...............................tpt...t.........................................................................................................................................................................s...sspsh.lG....t....p....QhpWLhpt........L.t...pup...........upW.p..l..l..us..p.h....hs....h......s..................................................................................................h.s..h..-.s.Ws.............G..a.....t.p.pp......c...lhphh...........tp....t.....t.....h....p.....s....hl..hLoGDhHhs.hs.t.c.ht.t....................................................hhEhssss............lst.......................................................................................................................................................................................................................................................................................................................	0	272	518	709
+9256	PF09424	YqeY		Yqey-like protein	Bateman A	anon	Bateman A	Domain	The function of this domain found in the YqeY protein is uncertain.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.67	0.71	-4.34	42	2465	2012-10-02 13:42:24	2007-01-24 12:41:00	5	3	2421	1	718	1873	2150	142.00	36	94.47	CHANGED	+-+lppDhKpAMKA+DKt+LuslRhlpAAlppcElctpt....c.LsD--llsVLsK.lKQR+-SlppappuGRpDLs-pEpsElpllppYLPpQLo--ElpshlppsIu-s...GAs.....uh+DMGKVMuslps+ltG+A.DhutlSshVKptL	.......................................................................................pplppDhK.pAMKAK..D..c.+..L...sslRhlpAAl..ppt-.l....ctpt.........................p..L..sD-.c..ll..slls+..lKQR..+-Slpt.appu...G..R.p..D...L.A-p....EpsEl.sllppY...L........P....p......pL..o--E.lpshl.c.ps....I....sc....s....G.As.......u.h.p.D.MGKVMssl.ps...+...l...t...G...+...A...Dsstl.uthVKphL........................................	1	253	495	623
+9257	PF09425	CCT_2		Divergent CCT motif	Bateman A	anon	Bateman A	Motif	This short motif is found in a number of plant proteins. It appears to be related to the N-terminal half of the CCT motif. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif [1].	21.00	21.00	21.00	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.76	0.72	-7.10	0.72	-4.40	18	348	2012-10-01 19:54:00	2007-01-29 13:51:09	5	9	35	21	176	437	0	26.20	60	10.36	CHANGED	PlAR....+uSLpRFLEKRKcRlss...ssPY.s	...........PhAR....K.sSLpRFLE..KRK-.Rlsu...tuPY..t......	0	26	104	145
+9258	PF09426	Nyv1_N		Vacuolar R-SNARE Nyv1 N terminal	Mistry J, Wood V	anon	Pfam-B_50964 (release 21.0)	Domain	This domain corresponds to the N terminal domain of vacuolar R-SNARE Nyv1 which adopts a longin fold [1].  In yeast it has been shown that this domain is sufficient to direct the transport of Nyv1 to limiting membrane of the vacuole [1].	25.00	25.00	151.30	150.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.97	0.71	-4.62	5	27	2009-01-15 18:05:59	2007-02-05 13:24:10	5	1	26	1	15	24	0	136.60	63	56.58	CHANGED	VSYVEVlcsG+olSSC..Ycsts.ssusYGslousscuss....TP-lFHsLIsDMVlPKVVslsGNKVTKMShsLIDGYDCYYTT..cscDsspVLVCFT+lDlPKILPIRlLS-LKphEst......DsDEhLSuslGsILDsFHcELloYRNp	VSYVEVI+sGcTlSSC..Fpshp...pspsYGolsss...scph.................TPslFHpLIhDMVLPKVVPIcGNKVTKMSMsLIDGFDCaYoT...-D......cDscTVaVCFThVDIPKILPIRlLStLpchEuN..........uTsEhLSuHVGpILDuFHEELlpYRNp.	0	1	6	12
+9259	PF09427	DUF2014	SREBP_C; 	Domain of unknown function (DUF2014) 	Mistry J, Wood V	anon	Pfam-B_71890 (release 21.0)	Domain	This domain is found at the C terminal of a family of ER membrane bound transcription factors called sterol regulatory element binding proteins (SREBP).	20.20	20.20	20.70	64.90	17.60	19.80	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.58	0.70	-5.25	8	72	2009-01-15 18:05:59	2007-02-05 14:12:33	5	3	72	0	59	73	0	263.90	50	26.35	CHANGED	+shKaoLRsllG.psY..uaLTGsoE.....EpEtARlKAWsIALDAQLsGGDsElSKSRLsLTlhASGTLPcTPtRlMLKALHsRVLLWcl....ssshplsspluuclARhpWNtARphpphLsp......ucccsLPEHLAsLLEp-.sDDVhssuIlQRAaNLA.WNRsTscsshsp..ssuhDsVVEDsAl+SPLDALAAWYSSpsLp+sLhpoL...pspsts.....upcshhscIslAlplAPhsSsAphRALVA+AVlhsccRussIssALsAls.spss	.............+shcasLRsllGh+hY..uhLTGlTE.....EpEtARVKAW-IAlDAQLsGGDsElSKSRLlLTlhASGTLPcTPtRlMLKALHsRlLLWclu..suhshtluNtlAtpLARhpWshARphpchLsp............sp-DsLPcHLAsLL-tD.CD-VhsDsIlQRAtNLA.WNRsTp-ssssc..pshhDsVVEDsAlpSPLDAlAAWWSSphLQcALlpsL.....-hssss.......................hcspcshppplclAlclAPhsSsAasRAlVs+AVhh-ccRsssIsssLtALs.p.ps...	0	10	26	46
+9260	PF09428	DUF2011		Fungal protein of unknown function (DUF2011)	Mistry J, Wood V	anon	manual	Family	This is a family of fungal proteins whose function is unknown.	24.50	24.50	25.00	27.70	22.50	24.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.09	0.71	-4.27	37	112	2009-11-20 16:11:53	2007-02-05 17:05:15	5	2	109	0	85	112	0	149.10	29	52.01	CHANGED	+lpLRpso........schlss.RshsYYFsp.s.tp...........................+cpFpsuAlou-slhphup.hsas.......tsphPWRVlclp.....pttsphppp...t.................t...p++++PGKK+Rlth+pp.............ttcp.....tccp.......-t-K+..........p++p+cKKh++...............Rtpp+p+	.......................+lpL+p.s........tthlsstRPhsYYFus.pttp...........................+ppFppuAVou-sllptup.hsa...................usphPWRVlclp..ttssphctptt..t............................................pctpp+++RPGKKpRlshRtp.............ttcp......pEcp.....p+-K+..........pR+N+cKKh++....Rtpc+pp..................................	0	14	41	71
+9261	PF09429	Wbp11		WW domain binding protein 11	Mistry J, Wood V	anon	Pfam-B_13108 (release 21.0)	Family	The WW domain is a small protein module with a triple-stranded beta-sheet fold.  This is a family of WW domain binding proteins.	21.10	21.10	21.70	21.70	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.64	0.72	-4.00	30	272	2009-10-15 16:14:36	2007-02-06 10:25:24	5	9	212	0	198	259	1	77.90	41	17.48	CHANGED	c+shNPs-utRKppKcKElKKsKp-RpptRcttlt++sPcplpcplccLcph.EtsttL.....pstc+p+lcpLEcslchlt+	.......tK.hNPsDttRK.......pt+K+ELKK..........NKcpR.hsRss..hLtt..KDPcpIhcph-cL-ph..Ehss.h......................cps.+c+hcpLccshctlh...................................	1	63	99	149
+9262	PF09430	DUF2012		Protein of unknown function (DUF2012)	Mistry J, Wood V	anon	Pfam-B_49614 (release 21.0)	Family	This is a eukaryotic family of uncharacterised proteins.	26.60	26.60	26.60	26.70	26.50	26.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.55	0.71	-4.28	26	303	2012-10-02 19:08:27	2007-02-06 12:46:16	5	6	253	0	216	352	5	118.10	28	48.11	CHANGED	hsstshhsssplhL............su......................spa...hshl+pDGoFshpsVPsG....oYll-lpsssahFss...lRV-ls......psphcutplshhpstpsh.........................hshPlhlcshuhtpYa..Rcpaslhsl..LpsPMlLM	......................................th.sss+lhl..................su..................................spt...huhlppDGoFshpslP.s.G............SYll-lt....s..sahFpP...lRVDls................ttphc.s....ph...lshhpst....p.s....p...........................hsh....P.Lph.csh..u.hpYappRcpa..shhsh..L.h.NPMlLh.................................................	0	76	117	175
+9263	PF09431	DUF2013		Protein of unknown function (DUF2013)	Mistry J, Wood V	anon	Pfam-B_11317 (release 21.0)	Family	This region is found at the C terminal of a group of cytoskeletal proteins.	21.40	21.40	21.80	22.70	20.20	21.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.73	0.71	-4.42	23	255	2009-01-15 18:05:59	2007-02-06 12:52:43	5	8	227	0	183	253	1	139.20	34	23.37	CHANGED	ss-.hs..hl+LLLslNEQahhsuht..............pNtVhchL..............ptssh+sFsEpLlLhlNR-pDs......lplh.........lLKhLYLlFT...ossThchFYsNDL+VLlDIlIRpLssL......ssctchLRtTYL+VLtPLLppTplpch...Y++s-lhcl	..............................................................s.p-.h...hlplLLshN.pahhss...................................pNhlhpsL..............pts....sh+sFsEpllLLLN.Rts-s....................lplh..................lLKhLh.lFo...os..sT.t...p.hFYsNDl+VLlDIllRpLhDL............sssstLRhpYLclLhslLppTphpp......a+ps-lht.h.................	1	60	94	148
+9264	PF09432	THP2		Tho complex subunit THP2	Mistry J, Wood V	anon	manual	Family	The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1 [1].	28.00	28.00	29.10	31.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.71	0.71	-4.29	5	26	2009-09-11 02:57:22	2007-02-06 14:47:07	5	1	25	0	15	20	0	127.80	61	49.81	CHANGED	hLpYINLLs+LSVDLA+QlEsuD..sssclhV-+hsPPsELQulLcpYss...-ss-scsLRAcLp+YLD-IKMsRAKYuLENKYSLp-oLppLTKEVScWRccW-sIEsLMFGDuPsSMK+MlQsIESlK.cpLTs	..hLRYINLLcRLSVDLAKQVEVSD.PSVTVaEhDKWsPs-cLQuILEQYss...P-TDIcslcAQlcsYLDQIKMuRAKauLENKYSLKEpLsTLTKELN+WRKEWDcIEMLMFGDsAHSMKKMlQpIDSLK.Scls.u...	0	1	6	12
+9267	PF09435	DUF2015		Fungal protein of unknown function (DUF2015)	Mistry J, Wood V	anon	manual	Family	This is a fungal family of uncharacterised proteins.	20.90	20.90	21.50	41.90	20.80	18.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.69	0.71	-4.36	20	119	2009-01-15 18:05:59	2007-02-07 13:30:17	5	1	117	0	90	111	0	120.20	43	87.04	CHANGED	Ms..hllYhhshhlllsuT.hlahsRpRWhsh....h...........lschhYs+Ls....SFssDlEAGLSSosFDLuu.Nl..ssuDsRuGLD-puKcEIp+IM+pcplsFD-ARhlYhcc+FucNsIuPD.GpPRDPK	..............................hha.h.hhhhllhss..hhahhRp+hh.h...........................hsshhYs+LP.....SFpsDlEuGLSSusFDLsu.Nl..ssuDsRuGLDctuKcElh+IM+pc.plsFD-ARhlYhcp+FscNs.IGPD.GpPpDPK..	0	23	49	79
+9268	PF09436	DUF2016		Domain of unknown function (DUF2016)	Mistry J	anon	Iyer L	Domain	A predicted alpha+beta domain that is usually fused N-terminal to the JAB metallopeptidase. This protein in turn is found in conserved gene neighborhoods that include genes encoding the bacterial homologs of the ubiquitin modification system such as the E1, E2 and Ub proteins [1]. The domain is also known as the JAB-N domain.	19.80	19.80	20.00	22.90	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.31	0.72	-4.41	14	40	2009-01-15 18:05:59	2007-02-07 13:38:47	5	1	34	0	23	41	0	71.90	37	32.17	CHANGED	hDthLQssFPolhsP+aGs.lsshppsGcRhllAusGlalElpRsWLcslpplu...t.psslPYGplscplchh	........................hDtsL.suhPoVhVP+aus...lssh..p..psGcRlLluusGlalElpRPWLcllptlu...s.sstlPYGsVpEphchs......	0	4	12	19
+9269	PF09437	Pombe_5TM		Pombe specific 5TM protein	Wood V, Bateman A	anon	Wood V	Family	\N	19.10	19.10	131.50	41.20	18.00	16.50	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.83	0.70	-4.96	2	8	2009-01-15 18:05:59	2007-02-07 13:40:20	5	2	1	0	8	9	0	120.00	34	85.26	CHANGED	uhhcchNoQ.NR.M........ppSshs.pNIs..hhslhIsc...TspYClAs+.........................................lLlaL.Y...................ChYI..au.s.olppphcpasFus.slhappFas..c...FlRTp...........uhs.hRThsKa.hI....IlhulppVhh.p.hpcsYsho-I.DhhQ.......................sYpNss.uRFhpR	.....uhhcchNoQ.NR.M........ppSshs.pNIs..hhslhIsc...TspYClAs+..................................................................hChYI..au.s.ohppphcpasFus.slhappFas..c...FlRTp...........uhs.hRThsKa.hI....IlhulppVhh.p.hpcsYsho-I.DhhQ....................................hh..........	1	8	8	8
+9270	PF09438	DUF2017		Domain of unknown function (DUF2017)	Mistry J, Iyer LM, Burroughs AM, Aravind L	anon	Iyer L	Domain	This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB  peptidases [1].	25.00	25.00	25.10	33.00	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.15	0.71	-4.71	19	377	2009-09-11 16:56:57	2007-02-07 15:24:14	5	2	375	0	100	254	96	175.00	33	92.35	CHANGED	ht+ppshtGsphputl-PtEsplLpsLsuslhshLpp..pstsuPpD.LutlsGh.sGpsp.PpDPsLtRLLPDhaps-s-ss.ss...........uthRpLpEs-lhcsKhssuphlhcsL......Pts.....usclpLot-pAcAWluuLNDlRLsLus...tLclss-ss........-t..s-cshs.phslYpWLTalQESLlpAlhu	.................................................................................................t.th.s.ht.hEhtlLtslssth.thltt...........t.....t...p....ss.s....t.D..Ltth.h...u.......................ss.........sp.P.........p..DPsLtR.L.LPDha+sD-pss....................uthRsh+Es-lhsAKhtsApslhssl................scs........uuplpls.ppApsW..lsulNDlRLslustLsItscss...................tchst.p.c...s...ts...s.chsVYp.WLshlQEsLVpshh........................................................	0	31	77	96
+9271	PF09439	SRPRB		Signal recognition particle receptor beta subunit	Mistry J, Wood V	anon	Pfam-B_7840 (release 21.0)	Family	The beta subunit of the signal recognition particle receptor (SRP) is a transmembrane GTPase which anchors the alpha subunit to the endoplasmic reticulum membrane [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.17	0.71	-5.06	8	357	2012-10-05 12:31:09	2007-02-07 17:41:34	5	11	294	5	246	9068	2252	182.20	30	56.77	CHANGED	ospsslllsGlssSGKTsLFspLoTs.....shpcThsS..Esssuh+h...ps.+GsphTLIDaPGH-+LRhcLl-phhtpus.l+ullFVVDSol.sKclp-sAEaLYplLo.othh.csslsILIACNKp-lhhA+ssphI+puLEKElsplhcpRutuLssh..........-uss-tss.LsppGcsFcFspLcsp.V	...............................................t..tpslLL..sG.ss.SGK.T......s.....L....as......p..L..h.p.s........................................ph.t....t....T....h....T....S......h.......c...s.s.....s..s.h....t.h........................t..t..t...p..s...p...s..h...........p..L..l......D....h...P...G...........H..........t.......+......L..........R.......................p..............h.......h....c......h.................................................t................s..............p.........s........+..........u..........l.......l.......F..V..V...D.......o....s.......s.........h...p....c.............p....l........c...s..s.A..E...a....L...Y...s..........l...L...........h.........s...........s.p...........h.............h.........p.........p.............p........h.............s.lLl.s...C.NK.......p..D...h..........h....s.....A....c...s...s....p..h....l...+.....p...t.........L..E....p..El.s....p.....l..R.h.o..Rsts.lpsh......................-tst.p.............h....l.s..t.....u..p.t..F.pFpph......................................................................................................................	0	85	137	199
+9272	PF09440	eIF3_N		eIF3 subunit 6 N terminal domain	Mistry J, Wood V	anon	Pfam-B_4886 (release 21.0)	Domain	This is the N terminal domain of subunit 6 translation initiation factor eIF3.	25.00	25.00	25.40	26.50	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.68	0.71	-3.99	23	318	2009-01-15 18:05:59	2007-02-08 09:34:55	5	6	244	0	203	294	3	126.30	37	30.33	CHANGED	DLstKlhsaLDRHLlFPLLEFhusctha-p..........p-lhcA+h-LLpcTNM.sDYshslhpcl....sscphPsEhsp+RppVlppLpcLppcssplhclhpc.-llssl+o..D+stNlcaLp...cc+slTh-hlsuLY+aupap	.........DLTs+ls.aLDRHLlFPLLEFLss.....p..p.l..as-................c-llpuKh-LL.p..cTNM.l.Dash-lacpL........sc...-.........hPpchtc+RppV.lspLc.pLppcspslschhp.ss-sspphco.....Dpph.hc.aLp...cc....+.s......h................p.-hl.ssLYcau+FQ......................................	0	78	113	163
+9273	PF09441	Abp2		ARS binding protein 2	Wood V, Bateman A	anon	Wood V	Family	This DNA-binding protein binds to the autonomously replicating sequence (ARS) binding element. It may play a role in regulating the cell cycle response to stress signals [1].	25.00	25.00	28.70	27.80	24.60	19.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.08	0.71	-4.35	6	71	2009-01-15 18:05:59	2007-02-09 13:41:04	5	2	68	0	58	71	0	167.70	58	23.27	CHANGED	pRsLPsRc.Vos-oI-DAYsuFILYCNPsVshsTDTspLRcsFRsPPKS-GKSFSoasLFELI+pL-sKEIKTWupLAlcLGVEPPD.EKGQSoQKlQQYAVRL..KRWM+uMHVDAFFEYLLG+.HPYaspIPPspsPlu-htRDGVssE-DLALRALlPch+P+RGR+Ks--h--ss	.....s.RsLPsRc.lT.s.pTI-DAYVsFIhYCNPsVPhs...oDTspLRcsFRsPP+S-GKoFohFsLapLIcK.L-pK.ElKTWhpLAlcLGVEPPshEKcQSoQKVQQYAVRL..................K.....RWM+uMHVDAFFEYhlG+sHsYaTplPsssss..hs-..RDGVshE-DhALRALlPch+PKRGRKRs--cp..t.............................	0	10	27	45
+9274	PF09442	DUF2018		Domain of unknown function (DUF2018)	Coggill P	anon	manual	Domain	Acid-adaptive protein possibly of physiological significance when H.pylori colonises the human stomach, which adopts a unique four alpha-helical triangular conformations. The biologically active form is thought to be a tetramer. The protein is expressed along with six other proteins, some of which are related to iron storage and haem biosynthesis [1].	25.00	25.00	30.20	29.90	22.70	17.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.50	0.72	-3.42	14	194	2009-09-11 13:54:03	2007-02-09 16:45:20	5	1	193	8	23	82	2	81.60	53	91.25	CHANGED	FtGoP+-KFh-IlhpANpsllcpElEclhcchsshcplhEcp.Gls.........Epcl+sahhcpsch..lcsthsslYIEhhGcILopsE	..............FspoPKEKFhEIIpNuNhsslEK.hEchFtcalAM.ELLEKp.Gls.........Eh..-sK...sFILENuDh...IE-RpNDlaIELuAcILu+p.t.	0	6	19	23
+9275	PF09443	CFC		Cripto_Frl-1_Cryptic (CFC)	Coggill P	anon	pdb_2j5h	Domain	CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours [1,2] and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2 [1].  CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain [1].	20.20	20.20	20.50	20.50	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.17	0.72	-4.32	9	108	2009-01-15 18:05:59	2007-02-12 15:04:21	5	3	47	1	44	92	0	33.30	52	19.83	CHANGED	CGu.l.HGsWl.+uCpLCRChaGsLHChPpph.scCD	......CGu.lsHGsWl..+tCpLCRChaGtLHCFPpth.ssCD...	1	6	8	16
+9276	PF09444	MRC1		MRC1-like domain	Wood V, Bateman A	anon	Wood V	Family	This putative domain is found to be the most conserved region in mediator of replication checkpoint protein 1.	25.00	25.00	25.90	25.90	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.23	0.71	-3.87	12	137	2009-01-15 18:05:59	2007-02-12 16:05:59	5	3	132	0	101	140	0	137.30	40	11.45	CHANGED	hc+pshsshlEtEAEES-DEa.........tGlGGs............DsEto..--.su-lccMIDD...pstpchcscpltp.hhhpcppptDp+.lpKlLcDIpsGshR.+Rh...tNuh-h-lS.Ds-D-.lpphR.p..+Rc...hh+p+hLpssc...hspLscNsKupAFaco	.......c+pts+chlEppAEESE.DEa...................tGLGGs...................-sEsu...--p-spsccMIDD...tsspshcpcclst.hhApcp+ppDc+plpKLh+DIp.sGtLR.++R.....su.-...h-LS..Ds.-D.-thtph.Rht..RRcht.ch++tLLtscc...ltclucNPKppAFhco............	0	25	53	85
+9277	PF09445	Methyltransf_15		RNA cap guanine-N2 methyltransferase	Wood V, Bateman A	anon	Pfam-B_9480 (Release 21.0)	Family	RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyse methylation of the exocyclic N2 amine of 7-methylguanosine [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.12	0.71	-4.69	11	426	2012-10-10 17:06:42	2007-02-12 18:11:39	5	9	324	7	290	6417	1083	156.50	32	33.86	CHANGED	tphlLDlFuGuGGNsIpFAp....Fp.Vhul-hshp+ltpst+NAcsYGV.sc+lhhlhGDahp...........................................hlsph+htph...hDsVFhSPPWGGPsYpcppsaDLpp.plpPhslppllcs............shplopNll...lFLPRNosLsQL.....................................................splshclhssts+Cp.................lh.hppNGhhKulhsaaGpt	..............................s.hllDsFs..G..sG..G...N..s.I....p..F.....A..hp...............h...p....+..V...l..A..lD..hDst+lphA....c.+...N.....A....p.l..Y.......G..V.....s......-.......+...I....p..a..l....p.G...D.h.hp................................................................................................................l.h..t...p...h..p.................hD.s..V.Fh.S.P.P...W....G.G............P....s....Y.............t..p.............t.....p........s.............a.....c.l.p.....h......h....p....P...h..sh......plhph..........................hpph..o.p...p....ls.......ha..LP.Rss.slp.Ql...........................................................sph...............t..p....hc.................l.p...h.pst.pslhhhhs..h.........................................................................................................................................................................	1	114	171	246
+9278	PF09446	VMA21		VMA21-like domain	Bateman A	anon	Mitreva M	Domain	This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localised in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase [1].	21.30	21.30	21.60	22.70	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.16	0.72	-4.05	18	286	2009-01-15 18:05:59	2007-02-13 13:09:18	5	7	216	0	203	272	2	62.80	32	50.42	CHANGED	ssuVlhKL......................lhFoshMlslPlssaFshpthl..........hts..th...s..ssshhuGlsAslssplVLshYlhhAa	...............................ssltpL..........................lhFoh.hMlslPlusaFsspphl................hpu...............ss.shhuuhhAllssplVLshYlhhAh.............	0	50	97	165
+9279	PF09447	Cnl2_NKP2		Cnl2/NKP2 family protein	Wood V, Bateman A	anon	Wood V	Family	This family includes the Cnl2 kinetochore protein [1].	21.40	21.40	21.90	29.30	21.30	19.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.92	0.72	-4.30	11	88	2009-01-15 18:05:59	2007-02-13 13:17:23	5	2	87	0	64	79	2	66.90	42	34.58	CHANGED	sEppILssaLLssupL.sIISLppFpc...LFP+plpssPpI.csLY+-LQpQRp.pslDpVpspI-pEhcp	...oEssILsNaLLoPusLPolISLppFsc...LFP+pl.....po.cPpl.RsLYR-LQp.Rs.psl.DhVptNIcpEh+.t........	1	14	30	51
+9280	PF09448	MmlI		Methylmuconolactone methyl-isomerase 	Coggill P	anon	manual	Domain	MmlI is a short, approx 115 residue, protein of two alpha helices and four beta strands. It is involved in the catabolism of methyl-substituted aromatics via a modified oxo-adipate pathway in bacteria. The enzyme appears to be monomeric in some species [1] and tetrameric in others [2]. The known structure shows two copies of the protein form a dimeric alpha beta barrel.	29.60	29.60	30.20	31.90	28.70	29.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.55	0.72	-4.32	3	8	2012-10-02 00:20:33	2007-02-13 14:42:15	5	1	8	14	3	13	0	105.10	71	95.79	CHANGED	IRLLYLLVKPAGMSDETFRAECLRHYEMSHDVPGLHKYEVRLVAEQPTDTHVPFFDIGHVDAIGECWFKDDAAYATYMASDIRKAWFEHGKTFIGQLKPFRTAPVAGDEPAS	.....IRlLYLLVKPEuMScEpFRtECL.RHaEMStslPGLHKYEVRLVAp..pPTDTHVPFFDlG+VDAIGECWFcsEtsYpsYMsSDIRKAWFEHGKTFIGQLKPFhTtsVs......h.........	0	0	1	2
+9281	PF09449	DUF2020		Domain of unknown function (DUF2020)	Coggill P	anon	pdb_2i8g	Domain	Protein of unknown function found in bacteria.	25.00	25.00	38.50	42.00	20.40	17.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.75	0.71	-4.52	4	58	2009-09-11 14:12:22	2007-02-14 16:43:04	5	2	56	2	15	52	0	138.70	53	78.50	CHANGED	LPlDAhPtsP.GRsu.ptCPYLDocWVADTNGQRlTGhGsDERFsTPACVFWSYPEtPQhTVhVRcMsTp-DAIAVVDWAAPIDoTE.AEEPsGWSGGRRGGscpSGAlYAVQKsssAVlVaTNQ-QSLKAQLlAEEsIpNLGL	...............................P.....p.ss.....scCPYLDopWVA-TNGQRhsu.GlDsRFsTPACVFWSYs--PQhTVhVRcMsopp-AhtVVDaAAPIDoTEPAp....-PsG...WSGGR...tu.....ss...cGAlYAVpKGssAVVVaoNQpQSlKAchIAcEsIspLuL.........................	0	4	11	15
+9282	PF09450	DUF2019		Domain of unknown function (DUF2019)	Coggill P	anon	pdb_2i9c 	Domain	Protein of unknown function found in bacteria.	20.70	20.70	20.70	21.40	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.20	0.72	-4.18	7	37	2009-01-15 18:05:59	2007-02-14 16:49:09	5	2	22	1	27	37	0	101.70	31	82.69	CHANGED	sptLVtRFAclultQDsAlLts-hu+FNRLascMtplssELKpRsGDQRpALhsLasHPNMQVRLpAAKtTLAltPsEARppLEAIAsS+WhPQAGDAGMsLhpLD	..........pcLVtpFschshtQscAlhts-tpphN+hacchhtlhscL+u+ssst.RpuLhsLhcHPshpVRlhAAttsLt..htsscA+thLptlupt....................................	0	1	14	22
+9283	PF09451	ATG27		Autophagy-related protein 27	Wood V, Bateman A	anon	Wood V	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.91	0.70	-5.16	14	241	2012-10-02 14:19:22	2007-02-15 13:10:36	5	15	184	0	180	355	1	221.90	18	72.68	CHANGED	sshhhuhtsssuuhcCspppl...ppYclspluu.pslpsscsTPPopsphpahlslC......pcsshps.cpCsss.stlCulp.hhhsst...sshsopllshtpsspsshcthts............tGlplphsG.......tsauspphcAplpapC....ssstsusEhps......................................................sstssp.lclshps..uC.p................t...t.......ttsspsssppuss.....usthGaFTWLFlhlhLhh.slYllsGuahNasphuspsa.....-lls+u.-hl+slPhhh+-hlp+........llsshpG.........suuRG	..................................................................................................................................................................................hs..........................................................................................................................h.hs.s.....................C............hC.h...................h...hh....s....h.....................t.....t..p...t..........................u.l.l..hp.u............t...t....t....t.t...ps.lph...C....s..ph.p.t....p..h.........................................................................t..s...t......h.p..lphps...uC..............................................................ts.ttstp.......................usthG.aF...s.hlh...l..l.h...hlh.h.ssYllhGuhhshpt.hutpG.h.......-hlPph.-hhps.lPhhhp-hhth........hhtt.ts.........................................................	0	83	123	159
+9284	PF09452	Mvb12		ESCRT-I subunit Mvb12	Wood V, Bateman A	anon	Wood V	Domain	The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified [1], multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23) [1].	25.00	25.00	81.30	81.10	21.80	17.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.03	0.72	-3.81	4	24	2009-01-15 18:05:59	2007-02-15 13:39:10	5	1	23	1	15	20	0	91.10	53	88.18	CHANGED	hLR+IPLYNtatss..aP+cR.sKlplPthpl.shssTt-hLpsWhcECccIhcssp.+cppscpF-pWYpEpYLupKPPGllps....shLuPpRK	.lLR+IPLYNKYGc-..FP.p.EslsRhphPEaKLPsLQ.PTc-hLsPWYEECDsIs+s.CphHDuSsKcFDpWYcEpYLSKKPPGllss....slLSPSRK...........	0	1	6	12
+9285	PF09453	HIRA_B		HIRA B motif	Coggill P	anon	pdb_2i32	Motif	The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between HIRA Pfam:PF07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions [1]. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus. 	21.00	21.00	21.10	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.47	0.72	-6.80	0.72	-4.30	30	239	2009-01-15 18:05:59	2007-02-15 14:15:42	5	22	194	2	167	262	0	23.40	48	2.46	CHANGED	pQpsThTKsGKKRlAPhLlSouss	.....KQp.ThTKDGK+RIsPlhlupss....	0	36	73	131
+9286	PF09454	Vps23_core		Vps23 core domain	Coggill P	anon	pdb_2caz	Domain	ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (Pfam:PF03997) and Vps37. Vps23 gives ESCRT-I complex its stability [1].	20.60	20.60	21.10	20.70	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.55	0.72	-4.36	19	362	2009-01-15 18:05:59	2007-02-15 14:37:13	5	6	269	7	223	353	3	62.60	44	14.79	CHANGED	-phltstsslhpQlhcLlAc-pAl-DsIhhLscuLcpGpIsl-palKplRtLuR-QFhtRhhhpK	.........D-lllsssslh+QllsLhAEEpAI-DsIahLucAL..c..+....G...s.....I....s...l.-saLKplR.LuRcQFhhRAhhpK...................	0	76	126	181
+9287	PF09455	Cas_DxTHG		CRISPR-associated (Cas) DxTHG family	Coggill P	anon	pdb_2i71	Family	CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins.  The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	22.30	22.30	22.30	22.80	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.31	0.70	-5.31	44	268	2009-01-15 18:05:59	2007-02-15 14:47:23	5	6	191	2	136	269	9	350.30	14	81.01	CHANGED	hllohlGss.............pappspYphsspp...............hco....thsttulhchhp......sschllhssss.....................................t...sshptlpptlpsphtp........................pslhlP..............................cGpsps.hhp...lahpl.hcp..l......pcss.clllDlTHGhphhP.hlshhuhphhttlt.......................tsphcslhhuhapsps...............hsshh-lsthhplhchhhsspphhphsssp.lsph..hppt...h.......................tpthpphhphlpslspul.lshshph................thhpplhphlppthphtt.........................hhth.hh.hlpplhpphphhstpp....................lcphhclhc.hahcpt.h........hpuhhltpE...............hpphpptpt+pphppth............................................pp....hhphhsphtphRNhlAHuGhp	................................................................................................................................hlshhGts................tap.spYhh..tspp.....................ps........thht.slhchhp.........schllhhspp...............................................................pphpthhptl.pphh.p..................................................................phh.lP........................................pupspp.hhp......lhppl.hcp...l.........ppss.clhl..DlTHGh+.hP.hlsh..hshphhphht.......................th.p.h.ptl..hauhhpsps.............................t.sslh-ls.sh....h.pl.hchh.uhptahph.sp.s..p.ltph.......htt..............................t.hpth......hp....hlpphppsl.h..hhhth...................p.hpphhp.lpph.p..t.....................................................hh.hhpph...pph.t...ht.tp....................htp..hphhc.hhhpt.t..h.........puh..hlhp.....E....hhh...t.........h.ph.pht.tpt.ht..h.....................................................................................t.....................ht....ph.p.hRN.hsHsuh..................................................................................................................................................................	0	69	89	110
+9288	PF09456	RcsC		RcsC Alpha-Beta-Loop (ABL)	Coggill P	anon	pdb_2ayy	Domain	This domain is found in the C-terminus of the phospho-relay kinase RcsC between Pfam:PF00512 and Pfam:PF00072, and forms a discrete alpha/beta/loop structure [1].	25.00	25.00	37.40	35.80	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.95	0.72	-4.34	12	546	2009-01-15 18:05:59	2007-02-20 16:07:56	5	4	538	2	41	289	1	91.90	68	9.90	CHANGED	pCWLAlRNspLppaLpslLutpGlpltcYp.sppsss-DllIoD.ssphshtspAhIphspcHIG.spEppPG.WhpSsusspEL.sLLs+Ia	......pCWLAVRNASLCQFLETSLpRSG.lsVspYE.GQEP..sPEDVLITD-sls+cWQGRAsVsFCRRHIGIPLE+APGEWVHSVAuPHELPALLARIY..	0	1	9	24
+9289	PF09457	RBD-FIP		FIP domain 	Coggill P	anon	pdb_2d7c	Motif	The FIP domain is the Rab11-binding domain (RBD) at the C-terminus of a family of Rab11-interacting proteins (FIPs). The Rab proteins constitute the largest family of small GTPases (>60 members in mammals). Among them Rab11 is a well characterised regulator of endocytic and recycling pathways. Rab11 associates with a broad range of post-Golgi organelles, including recycling endosomes [1].	23.00	23.00	25.30	23.60	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.19	0.72	-4.16	19	430	2009-01-15 18:05:59	2007-02-21 13:42:40	5	10	90	10	225	398	0	44.20	41	7.00	CHANGED	o+-ELhphltcpEcpht+.......Lc-YIDsLLlplMEcsPsILcss	.................o+-ELhptl..hcpEc..t+.......LccYIDplLlplhEpsPsILcl....	0	40	60	129
+9290	PF09458	H_lectin		H-type lectin domain	Coggill P	anon	pdb_2ccv	Domain	The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates [1]. It is sometimes found in association with the F5_F8_type_C domain Pfam:PF00754.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.00	0.72	-4.32	87	326	2009-01-15 18:05:59	2007-02-21 14:07:37	5	22	127	25	229	344	33	71.10	20	18.43	CHANGED	pphppslpFs.psFpp..hPpVhlulphhD..hsps........psh..phplpspslTtpuFs.lphpshsss.plhplphsahAlss	..................hplsFs.psF..ps.....sPtVhlulshhD...hsps........tsh..phplpspslTps........u..Fs.lphp...s..hsss..tl..hph..p..hsahAh..t.......................	0	170	204	223
+9291	PF09459	EB_dh		Ethylbenzene dehydrogenase	Coggill P	anon	pdb_2ivf	Domain	Eythylbenzene dehydrogenase is a heterotrimer of three subunits that catalyses the anaerobic degradation of hydrocarbons. The alpha subunit contains the catalytic centre as a Molybdenum cofactor-complex. This removes an electron-pair from the hydrocarbon and passes it along an electron transport system involving iron-sulphur complexes held in the beta subunit and a Haem b molecule contained in the gamma subunit. The electron-pair is then subsequently passed to an as yet unknown receiver [1]. The enzyme is found in a variety of different bacteria.	26.20	26.20	26.30	27.10	24.20	26.10	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-12.05	0.70	-4.94	49	210	2009-09-13 05:32:36	2007-02-21 14:20:32	5	12	144	1	98	213	46	238.40	19	66.68	CHANGED	sssWsp....ssssplsl....hss.ssh.........................................................tsstpslpVpAsasucpl.ahhhpWps.........................................................................................stsh......................t.............tss.apD+lAlha..s..............s.tss.h.s..s........hpshssss.t.....................hhpahsss..................................sthl-l..WpW+u..t.........t.................t....s...........................................................ph........................tt.sht...s.p.p............................stsslpssu....a..psG....pWsVhhsRsLpss...s...-sshps.GpshshuhAla...-sspsp+stphu	.............................................................Wpph..hplsL.....hss...h.........................................................pthtt.lt.VpAsa....sup....pl.hhhhpWts...................................................................................................................................stsht..........................t.....................t.t.h.DphAlha..s.t...................sh.h.s..s..........s.hsth..h........................hhsss................................sthssl.ah..Wpu...................................................................s........................................................................................................t...pst..............................ts.t.htstu.....ph..tsG.....hWpl.hsRsLts.....s...t...psphp..Gt.h.huhAha...psp.hpp.hph...............................................	0	31	74	89
+9292	PF09460	Saf-Nte_pilin		Saf-pilin pilus formation protein	Coggill P	anon	pdb_2co1	Domain	This domain consists of the adjacent Saf-Nte and Saf-pilin chains of the pilus-forming complex. Pilus assembly in Gram-negative bacteria involves a Donor-strand exchange mechanism between the C- and the N-termini of this domain. The C-terminal subunit forms an incomplete Ig-fold which is then complemented by the 10-18 residue N-terminus of another, incoming, pilus subunit which is not involved in the Ig-fold. The N-terminus sequences contain a motif of alternating hydrophobic residues that occupy the P2 to P5 binding pockets in the groove of the first pilus subunit [1].	25.00	25.00	25.10	25.00	24.20	24.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.75	0.71	-4.41	4	84	2009-01-15 18:05:59	2007-02-21 14:30:22	5	1	81	19	1	51	0	138.30	60	90.19	CHANGED	GShlPNoEQppSVDlsFuuPppLolohsPVuGLhAG.ptustpIApLsVsSsohKpaulpG..hussVlsssGssWplsGKNoGptIpVsFuusshuppsus.paNG+pWhsaDhNDpLslhLsG.uQNVsADTYPlTlclsuYQs	.........GSFLPNTEQcKSVDISFAAPEcLTlSL-QsP.GLhAGKsKPsT.slAKLTVNSTS.IKEFGVR...G..VSsohl..NshGShWsITGKN.S.GsoluVGFS.......SpoLusS+SspsWNGl+WaTFDsN....DPVsIsLlt...DQNIPPDTYPlTVDVVGYQP......	0	0	0	1
+9293	PF09461	PcF		Phytotoxin PcF protein	Coggill P	anon	pdb_2bic	Domain	PcF is a 52 residue protein factor of two alpha helices, containing a 4-hydroxyproline and three cysteine bridges. The presence of the hydroxyproline is unique in relation to other fungal phytotoxic proteins. The protein has a high content of acidic side-chains implying a lack of binding with lipid-rich components of membranes and appears to be an extracellular phytotoxin that causes leaf necrosis in strawberries.	25.00	25.00	25.10	33.10	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.53	0.72	-4.06	5	31	2009-01-15 18:05:59	2007-02-22 13:45:16	5	2	5	1	11	32	0	44.60	56	36.26	CHANGED	QQLC+.AsGCAYEYScANtVVSKCC+AINs-PlAFHDCCpcSCNoG	QQLCp...AsGCA.Y.cYScANpslSKCC+sI.NscPsAFa-CCucSCNoG..	0	1	10	11
+9294	PF09462	Mus7		Mus7/MMS22 family	Wood V, Mistry J, Bateman A	anon	Wood V	Family	This family includes a conserved region from the Mus7 protein [1]. Mus7 is involved in the repair of replication-associated DNA damage in the fission yeast Schizosaccharomyces pombe. Mus7 functions in the same pathway as Mus81, a subunit of the Mus81-Eme1 structure-specific endonuclease, which has been implicated in the repair of the replication-associated DNA damage [1]. The MMS22 proteins are involved in repairing double-stranded DNA breaks created by the cleavage reaction of topoisomerase II [2].	21.10	21.10	21.20	22.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	614	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.13	0.70	-12.86	0.70	-5.68	17	141	2009-01-15 18:05:59	2007-02-22 14:11:52	5	5	120	0	111	150	1	490.60	19	29.02	CHANGED	hEthW.plhphhs......lsplsthshhhhssp.....tssWshlp.hhp.hh...p.t.t.........shspYtcs.....hhtRChhLhptasW..c.sp.llhp..LachFsppphhchcpEp.hppPt....h.lccLspsPohthpstp..hFchal+lLh.ulp.L...........tspcpl+shs.RlhPspshpYs+ppsl..tphs.LhN+asLLhsLhahsssshc.+lpplpp..lpstpuchcs.....phIslps.spLshhploppcchpsht.hsthhs.hlsphlcpah.hpt..p...........................hhpsFppphhcphhspspcplpshLphslpuhpshl............ptusshppsphllsps.lptlhph.p....pls....pcslphIpsaL..............tt......................tt..t...........t........................................................phhphlcplhp.slp..p.hsp.htts.s.-t.h............................................lhshlcsasphAphLVcpshp.hWs....hs...................astpsahtlp.sstpccas.hFhsphlphDstthp..chcpplhuhhhpsLlpphshlt.....pLhphlhsh.pps.hhp.hsh..t.....hplshsshpppcLsllosllpsh+...........................t.p.t+ppapchlpphhpsh+ssYtphtt........ut....ttahsFlp+llshl	.............................................EthWpthhthhs......h.phs.h.shhh.s.+............spWthhp.hht.h...h...t..s..t..........hspYhcs.....hhtpChhLhptasW....phsp.ll.h..lach....Fspp.phtshppEtshtp.P........................h.lpplstps.shthp....stp..sFchaL+llh.shp.h...............ptcplpshshRhlPspsh........pa.......s.cppsl..pphshLhN+asLLh..sLhhhss..s.s.hc.p..lptlpph..lp.tpucpcs.....p.lslcs.tpLshhtls...pt..c...sh.......ht.hhthhsphhpphlppa..htt..t.............................p.h.pphhp...h.ht..ppth.phl...h.s.hthh............ptt.....s...hhh......httlht.........th.........shthl.tah.......................................................................................................................................hpphht..........p.............t................................................h.thhp.a.thuthhlppthh..hs.....s....................hs..sh..ht.p....ppcah.hFh..hhp.ss...hp...php..phhphhhtslht.t............thhthl.p..................................htht.....ppphslhp.hhpshp................................................tt...ta.tphlp.hhtthp...tpht.h.....................t..........h.tFhtthlt..............................................................................................................................................................................................................................................................	0	27	60	98
+9295	PF09463	Opy2		Opy2 protein	Wood V, Finn RD, Bateman A	anon	Weod V	Family	Opy2p acts as a membrane anchor in the HOG signalling pathway [1].	21.10	21.10	21.60	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.06	0.72	-3.86	15	95	2009-01-15 18:05:59	2007-02-22 14:50:21	5	2	92	0	63	92	0	35.20	46	8.07	CHANGED	CVs.Csosss.oCPsCscGcpCshsStTCspCspThC	.CVs.Css.sss.sCP..s..CssuEhCsho.uhoCspCssshC	0	11	29	51
+9297	PF09465	LBR_tudor		Lamin-B receptor of TUDOR domain	Coggill P	anon	pdb_2dig	Domain	The Lamin-B receptor, found on the TUDOR domain Pfam:PF00567, is a chromatin and lamin binding protein in the inner nuclear membrane. It is one of the integral inner Nuclear Envelope membrane proteins responsible for targeting nuclear membranes to chromatin, being a downstream effector of Ran, a small Ras-like nuclear GTPase which regulates NE assembly. Lamin-B receptor interacts with Importin beta, a Ran-binding protein, thereby directly contributing to the fusion of membrane vesicles and the formation of the NE [1].	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.73	0.72	-4.34	5	85	2009-01-15 18:05:59	2007-02-23 17:27:58	5	10	51	2	45	73	0	53.10	54	9.68	CHANGED	MPupKYpcGElVMGRWPGSsLYYEVcVlSFDsKSQLYTVlYKDGTELELKESDIK	.........MPs.tKascGElVhGRWPGSuLYYEVcllSaDspopLYTVpYKD.GTE..LELKEsDIK...........	0	8	13	25
+9298	PF09466	Yqai		Hypothetical protein Yqai	Coggill P	anon	pdb_2dsm	Domain	This hypothetical protein is expressed in bacteria, particularly Bacillus subtilis. It forms a homo-dimer, with each monomer containing an alpha helix and four beta strands.	24.80	24.80	25.70	26.00	22.10	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.35	0.72	-3.97	2	32	2009-01-15 18:05:59	2007-02-23 18:12:33	5	1	25	2	4	31	0	63.30	35	82.67	CHANGED	MlENPMVhpNh......pc.s.hDh.I-.hhGsElhPsD-all.ssGEllLRENl.cYhhpQLGFEhKsAt.	.............t....................p...pEs-h.h-DhaGsElhssDcYll..ss.GEllLc-NLpcYLhEphGhchp..............	0	1	3	3
+9299	PF09467	Yopt		Hypothetical protein Yopt	Coggill P	anon	pdb_2dlb	Domain	This hypothetical protein is expressed in bacteria, particularly Bacillus subtilis. It forms homo-dimers, with each monomer consisting of one alpha helix and three beta strands.	25.50	25.50	25.50	46.40	22.20	25.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.42	0.72	-4.13	2	7	2009-01-15 18:05:59	2007-02-23 18:13:57	5	1	7	2	2	5	0	70.40	65	95.73	CHANGED	AGYLNNIALNLEIVLKNKADSPEVSETLVTRICENLLLSKEVSFLKADGSVENFKLSDMEYEITNTEELPE	..AGYLNNluLpLEIVLKNKAcs.EVSpoLspRlCEpLhlu+EVsFLpADGoVEpFKLsDhEYEIoNTEEl....	0	1	1	1
+9300	PF09468	RNase_H2-Ydr279		Ydr279p protein family (RNase H2 complex component)	Wood V, Chahwan C, Bateman A	anon	Wood V	Family	RNases H are enzymes that specifically hydrolyse RNA when annealed to a complementary DNA and are present in all living organisms. In yeast RNase H2 is composed of a complex of three proteins (Rnh2Ap, Ydr279p and Ylr154p), this family represents the homologues of Ydr279p [1]. It is not known whether non yeast proteins in this family fulfil the same function.	23.60	23.60	23.90	23.90	23.20	23.50	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.05	0.70	-5.22	42	345	2009-01-15 18:05:59	2007-02-26 08:50:54	5	5	278	16	229	334	0	283.10	21	86.68	CHANGED	s..s+lh.....lLPpssssst......hphlpLssPp.sspsstahh.....ppsplaElpthpt........................s.+Shhls.............................stlhpsuplhhsoshDslFlllshLhptt........................pspFhsl--ll......Dphhs...........thpphh.h.........hshlcpplptls-sh...............Esusc..pha+hsppKllpaLttKspphsph...l.pshp.phhpph...................................................................................th.pphhp.thhphuhshlsp.h.pphhpplhpt.hh............-ht.hpthhtt.................hppc+th.psh-uthsps...........pppppp.pttpKpsp...opst+....shtphsssGhp..plsuFF	...............................................t...hh.....lhs..p..t.t.........hphlpL....pPp..pu........psshalh.............p.pps..laElpthpt.........................th+SWhls.....................................................s.VtpsupLhhsTPhDslFllLs...hLhpsp................................ptpFhsl--ll.........Dp.hs............................thpplh.....................hthhcptlppls-sh....................................-.h..usp.....pha+hscpKhlpaLtpKspphs......ps....L.ts.p......phst.t...........................................................................................t..tp...p..hl..ph...Ahshlsphh.tp.....hh.ppl.hp.h....................t.t....t...................................p.p..........ptt...phs....................tp.tt...tt.ttpptt.......stt.c....th.t.ph.stpG..ht..plssFF..........................................................................................	0	78	128	191
+9301	PF09469	Cobl		Cordon-bleu ubiquitin-like domain	Coggill P, Bateman A	anon	pdb_2daj	Domain	The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node [1]. This domain has a ubiquitin-like fold.	25.00	25.00	27.70	26.80	23.30	18.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.68	0.72	-4.01	4	145	2012-10-03 10:59:06	2007-02-26 12:46:05	5	5	39	1	57	123	0	79.10	57	8.93	CHANGED	PsICpKCEFsPtHVlLL+DshupEEL-LsKSLs-LGIKELYAaDsp.............+EopphSSstss.o-KEKKuFLGFF+hsK+pps	......PlICuKCEhsPtHslLL+D..utE.L-LoKSLN-LGl+ELYAhDsp....................REohp.hS.....p...ss...p-KEpKtFhuFFptsK+pp.p.......	0	2	6	22
+9302	PF09470	Telethonin		Telethonin protein	Coggill P	anon	pdb_2f8v	Domain	Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerisation of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles [1].	25.00	25.00	41.90	41.80	19.00	17.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.02	0.71	-4.79	3	40	2009-09-11 00:10:22	2007-02-26 13:39:14	5	1	34	3	25	38	0	162.40	66	97.71	CHANGED	MATSELSCpVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQALVQRSPWLVMRMGILGRGLQEYQLPYQRVLPLPIFTPAKVGATKEEREETPIQLQELLALETALGGQCVDRQDVAEITKQLPPVVPVSKPGsLRRSLSRSMSQEAQRG	.......MAToELSCpVSEENpERREAFWAEWKDLTLSTRPEE..........GCSLHEEDopR+ETYHpQGQCQuLVQR.SPWLVMRMGILGRGLQEYQ.L.PYQRVLPLPIFTPs.KlGssKE.ERE-TPlQLpELLALETAL....G.....GQClDRQ-VAEITKQLPPVV.PV....S.....K.....P.GsLRRoLSRSMSQEAQRG.................	0	1	5	10
+9303	PF09471	Peptidase_M64		IgA Peptidase M64	Mistry J	anon	Rawlings N	Family	This is a family of highly selective metallo-endopeptidases.  The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase [1].	20.10	20.10	20.10	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.58	0.70	-4.76	14	251	2012-10-03 04:41:15	2007-05-02 11:06:12	5	20	205	8	66	360	113	241.70	28	47.19	CHANGED	apso--upcsstshppohphPssstssplshhph.tstpph.p.hphllc...P...c-.hhspstssssss.....lh.lhcoGs.spp+lDlllhG-GYTssEhscFhpDAp+hhcslFu.ppPa+pa+scFNVWulsssSp-S.........GV..upPpsshh+cohlGupassas..ERhltsscs+shppss...........u...hsPY-hl.......hllsNscpYGGuGhhsh........auslsucss.hushlhlHEhGHuhuuLADEYhsusssh.s......EPac.NlTs..sspth....KW	.............................................................................................................................t..h..........ts.hhp.t.t.tp........hhhlhpsus.sscplclsllu-GY..Tt....s..E...h...s...p...Fhp.D..A..ppth.-.sLF......u...tE.Pa+oh+stFNlhAVtssSp-S...........................Gl.......s.s......t.....p....s......h.h.....+..sTul.s..opF....s....s.ah....s...-R.h...Lss...s..phcshc.ssh............s......sssa.-.tl...............llLsNo.s...p...YG.....GuGhhss......................ashs.o.s..pps....h....hp.VllHE.h.G.HoFuGLuDEYhh.spss.h.th............thEPhc.Nlosh....s.s.t......KW.............................................	1	30	54	64
+9304	PF09472	MtrF		Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Many archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This domain is mostly found in MtrF, where it covers the entire length of the protein. This polypeptide is one of eight subunits of the N5-methyltetrahydromethanopterin: coenzyme M methyltransferase complex found in methanogenic archaea. This is a membrane-associated enzyme complex that uses methyl-transfer reactions to drive a sodium-ion pump. MtrF itself is involved in the transfer of the methyl group from N5-methyltetrahydromethanopterin to coenzyme M. Subsequently, methane is produced by two-electron reduction of the methyl moiety in methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase. In some organisms this domain is found at the C terminal region of what appears to be a fusion of the MtrA and MtrF proteins. The function of these proteins is unknown, though it is likely that they are involved in C1 metabolism.	21.00	21.00	21.40	21.30	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.77	0.72	-4.73	9	59	2009-01-15 18:05:59	2007-05-02 16:24:54	5	2	54	0	38	58	10	63.30	32	52.29	CHANGED	slshsscPphsuIpshV-sl+Y+uQLlARspKLsSGltusshhGhslGhlhAllhlllP.hlhh	.............l.hsspPphsuIcshlEslcY+spLluRct+LsSGltssslhGhshGhlhAllLlslslhlh.h..	0	8	24	32
+9306	PF09474	Type_III_YscX	type_III_YscX; 	Type III secretion system YscX (type_III_YscX)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are encoded within bacterial type III secretion gene clusters. Among all species with type III secretion, those with this protein are found among those that target animal rather than plant cells. The member of this family in Yersinia was shown by mutation to be required for type III secretion of Yops effector proteins and therefore is believed to be part of the secretion machinery.	20.50	20.50	21.20	35.80	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.50	0.71	-4.09	6	77	2009-01-15 18:05:59	2007-05-02 16:41:22	5	1	74	0	10	33	0	121.50	53	99.75	CHANGED	MSR.IoAhHIGIEpLotlShEElssuLPcRatLLPDGQuVETHlp+LYPtp.u-QtLhsaApPphsFHsLLRPcDaRQthcs....LppLLppssospLptAusLLpppppD-RLLQMALNLLHKV	.........MSR.loAhHIGIEpLotlShE-lsssLP-RatLhPDGpsVEsHLc+LYPttpocptLhDaApPphsFHsLLRPpDaRpphcs....LppLLspu.pSsp......LpAAAsLLpspQpD-RLLQhsLNLLHKV........................	2	2	4	5
+9307	PF09475	Dot_icm_IcmQ	dot_icm_IcmQ; 	Dot/Icm secretion system protein (dot_icm_IcmQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are the IcmQ component of Dot/Icm secretion systems, as found in the obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii. While this system resembles type IV secretion systems and has been called a form of type IV, the literature now seems to favour calling this the Dot/Icm system. This protein was shown to be essential for translocation.	25.00	25.00	27.00	140.90	18.10	16.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.10	0.71	-5.04	21	62	2009-01-15 18:05:59	2007-05-02 16:43:40	5	1	51	3	3	55	3	178.20	57	91.04	CHANGED	AILKALD-AIEpGPWEESNFLRVIGKNL+EIR-sFuspluss..sptps+ptoph.AsRlALRoGQQElFIuLYSo-GsNlQoWERIlANLPRQMISRPIYAsEpDV+slIKoKENKlNEAYVAIYIsQsDILslssDKsPhDKhGKPLLoLKD+ulsLENIsRFVHhSGlY+Ys+GR...LlKs	..ILKALs-AIcpGPW-cSNFLRVIGKpLhtIRDpFhcpluus..sps..cl+.s-.upL.ANRlALRSGQQElaVSLYSSDGoNLQSWE+IlusLPRQMISRPIYA-E-DlKsllKoKENK.NEAYVAIYIsQoDILplosDKsPsDKLG+PLLTLKD+oIsLENIoRFVHlSGVY+YspGRLIKp.......	0	2	2	3
+9308	PF09476	Pilus_CpaD	pilus_cpaD; Pilus_cpaD; 	Pilus biogenesis CpaD protein (pilus_cpaD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry consist of a pilus biogenesis protein, CpaD, from Caulobacter, and homologues in other bacteria, including three in the root nodule bacterium Bradyrhizobium japonicum. The molecular function of the homologues is not known.	30.10	30.10	30.50	30.80	29.30	30.00	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.32	0.71	-4.84	38	190	2009-01-15 18:05:59	2007-05-02 16:43:56	5	2	168	0	79	185	16	181.00	27	84.57	CHANGED	hllshshsLuuCsssss.......t..spshcppHPIsVpcsspslsl.lssstsuLossp+spltuahppatppussslhlpsPu.ss.st.s..Assshp-lpphLtptGlssspltstshtsssspssuslRlsas+hsA.psssCGtWscshs.sh.....hcNpsh.NaGCAspsNLAAMVANPpDLlpsRshosssssR.Rspsl...-pYRpu	............................h..hhhshhLuuCstt.............s..shptp+slslppsppslpl.lt.ttttLsssppspltshhtphhp..t..usshlhl.h....Ps.st.....t..utpshtpltphlsttGlsspplhhts.....st........s.t........ssu......s.lRlsa.phpA.hs.s.sCu.thspc..hs.ss..........hpNcshhNFGCAspsNLAAMlAsPtDLltPRsh.sssDusp.pssslcpYRp...............	0	21	40	55
+9309	PF09477	Type_III_YscG	type_III_yscG; Type_III_yscG; 	Bacterial type II secretion system chaperone protein (type_III_yscG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	YscG is a molecular chaperone for YscE, where both are part of the type III secretion system that in Yersinia is designated Ysc (Yersinia secretion). The secretion system delivers effector proteins, designated Yops (Yersinia outer proteins), in Yersinia. This entry consists of YscG from Yersinia and functionally equivalent type III secretion proteins in other species: e.g. AscG in Aeromonas and LscG in Photorhabdus luminescens.	26.10	26.10	26.30	44.40	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.45	0.71	-4.01	7	84	2009-01-15 18:05:59	2007-05-03 10:10:21	5	1	65	4	9	55	1	110.50	55	99.54	CHANGED	MphpL+t.LAElALhGoGpHpHpEAssIA-WLtppsp.pEsVsLIRlSSLMNpGcYppA..L..stshshPDLEPWhALCEa+LGLtutL-pRLstLuuSusPplpsFssGhRpQlps	MchcLpp.LAElALhGTGpHCHpEAssIA-WLcttuc..-EsVpLIRlSSLMNRGcYppA..Lt.utppsaPDLEPWhALCEa+LGLtuAL-sRLttLutpts.t.tsFssuhpppl+s...............	0	1	3	4
+9310	PF09478	CBM49		Carbohydrate binding domain CBM49	Mistry J, Urbanowicz B	anon	Pfam-B_6310 (release 21.0)	Domain	This domain is found at the C terminal of cellulases and in vitro binding studies have shown it to binds to crystalline cellulose [1].	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.82	0.72	-3.88	28	310	2012-10-01 21:34:18	2007-05-03 10:13:48	5	20	40	0	245	346	0	82.10	25	20.10	CHANGED	lslpQplTuoWhsssp.sY.hpassslsNpu...spslpslplpls.pl.....ssIWGlsp..usssYshPuWls...oLssGpohsFsYIp....s	..............................tlppphhsoWh...p...s...sp...sa.hpaslplpNpu...spslps....l......plshs...slt............sslWs..ls......p.....ss.....s.......t..........a....s....L...P..u..aht....sls.s.Gp.oa.s.FGYI..ps.................	1	165	230	238
+9311	PF09479	Flg_new	flg_new; 	Listeria-Bacteroides repeat domain (List_Bact_rpt)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This model describes a conserved core region of about 43 residues, which occurs in at least two families of tandem repeats. These include 78-residue repeats which occur from 2 to 15 times in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats found in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few other bacteria.	20.70	14.00	20.70	14.00	20.60	13.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-8.25	0.72	-3.92	74	3687	2009-01-15 18:05:59	2007-05-03 10:35:46	5	395	401	4	433	3605	541	42.10	41	10.26	CHANGED	PT..+...sG.YoFsG.WYssp.ssGspasas..ssh...spslTLYApastss	.............Ps...K....pG..YTFpG.W...Y.....s..s....p....ss........G.......s....c......a....sFu............Tshh.........ssss....l....T........LYApashs.s...........................	0	247	380	413
+9312	PF09480	PrgH		Type III secretion system protein PrgH-EprH (PrgH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	In Salmonella, the gene encoding this protein is part of a four-gene operon PrgHIJK, while in other organisms it is found in type III secretion operons. PrgH has been shown to be required for type III secretion and is a structural component of the needle complex, which is the core component of type III secretion systems.	20.40	20.40	20.40	21.90	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.93	0.70	-5.60	8	407	2009-01-15 18:05:59	2007-05-03 11:43:20	5	1	334	38	14	205	0	296.60	47	95.75	CHANGED	hhlRlLsGPLpGsEahL.sGpsLhllGpssuhspsupss-........hPtsTlalPhspGssNFclhls..............tssschhLchLs-pssppc.lsaNpshpsGslthsl+.tsEsWpsp...................ssht.susspspsRhtsuhhsslsshhhLuslhshtlhhhsoppc.QltpLsslLssssppaplLsGcDGplYlLAsopRDusWu+QuLh+sphspsVplls.ssEppRIppaLscphPtLsha+LcLscPppPhLh.LS+pRsuhspsthc+L.ttLhshhPYAcslslsshsDssltppAcpGLschulsYcchscssuVTFlIpuuLsDsEltclppal-sah+pWGupYVpFuIpL+-DaL+GKSaphGssGYVhlssuHWYF	..............................................................................lGpssuLstSsths-..........lPtsohhlPhschsssFEI.ls.................................sssh.lhh+.ELpttpsEs...RolpLNp.IpVhtLhhhl+.csEsW..p...................PthlEss...hhpsc.+Fhsuhl.....hth.s..hh..FhLhhhhh.hthhhhsusp........c..phtplsplLstppptaplL.GcD.p.h.lYl.sp..c-slWs+QsLt+sp.sKssRVIN.s-EshR.I.oWLss.aPpLtYa+Lph.-spp.hhh.lS+Q...RNshopp.l-sL.ptLhthMPYAsslsIslhDDsshtuQA.tsLpt.uLsYp+hpptssVhFsI.GsLsDsEl.+hppaVDpYY+pWGtpYVpFslpLKsp.hpspSFpYGspt.a.K.psupWhF..................................	0	3	6	9
+9313	PF09481	CRISPR_Cse1	CRISPR_cse1; 	CRISPR-associated protein Cse1 (CRISPR_cse1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	21.90	21.90	22.30	22.30	21.00	21.80	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.69	0.70	-5.74	55	645	2009-01-15 18:05:59	2007-05-03 12:04:30	5	2	613	4	118	467	12	456.40	33	89.10	CHANGED	NLlc-PWIPVhht.....sGs..pt.plulpplh.....pssclhslshspPshpsAlhc..lLlul...lpss...............................tsP....cs.tc..cWtchapp...........shssctlpsaLpc..apcpFpLhssp...PFhQssth............pscstslsp...............Llh-h...suusshhhh.sahscpuhsph...ssupAAhsLlshpsausu...Gh+suhp...............GuGPlssls.sh...........tGpsLacTLhLNllstp..............thssss............hssWpts.spsspptspthh.........sshhphahhhsR+lcLh....spsst.............spsshhstGh...shsssh............h.t.cPhssa+............hppppshhshc...hpsuphhWRshsuLlhspssss....ptt........stllchhtphttpth..................................hplhshGhchDs.pA.ph.hphptshlslssth.........pppthtpplpphlptAcphtptLcstlpphhtst..............ps-hshhst.............tpaWppsEstFhp.hlpslst...........ttsppttttWpppl....pphuhpha-p	.........................................LLssPWlPVRhc...................DGs........ss.clu.h-L.......ss.cslhc.lAusRsDhp.sAsap..hLLulLQsu..............................................huP.....cc..h.....cpW.c-lWpc...........ulps-tlcchLts..h..c.ctFphss-s..ssFMQsh.................p.hpscp......sslus......................LLs-h......PGupssch...-ah..hc+Gssch.....hsspsuAlALaohQh.A.Puh.GtGh+o.GlR.....................GGGPhTTLltl............pt.s.s.Lac..pL....WLNVhsp-........tthshstphcst............lhPWhss...s...csuchsusshs..........ttsshlpsYashPRRIRlc.....tphpsGsss............................................hsstpsstLlshhhhcsaussa............hW.p.HPhTPaR...............h.hKpss....tahsl+....spPGuhhWRcahuLltsspscs..........spp...................AtVlchhsshsh.ppht....................................lsLhuhG.h-h-s.hcu.psa..h-c.chslL...............tpcshhsplctssp....sA.s.c.l.h.....s.h.L...Rs.Al+-shhus....................pss+uDhuhlch........................cFWspopt...pFhp.llcplcps...........pcsc.-.hlspWp+pl....hhhspp.F-.............................................................................................	0	34	85	102
+9314	PF09482	OrgA_MxiK		Bacterial type III secretion apparatus protein (OrgA_MxiK)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This protein is encoded by genes which are found in type III secretion operons, and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene. In Shigella the gene is called MxiK and has been shown to be essential for the proper assembly of the needle complex, which is the core component of type III secretion systems.	25.00	25.00	26.10	25.90	23.10	22.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.06	0.71	-4.64	7	353	2009-01-15 18:05:59	2007-05-03 12:05:50	5	1	334	0	15	157	0	136.90	46	92.30	CHANGED	lhplhacPloYlHssRhslssthhss.stRslsNchllstYcLss-ht....tsshhthalspWphLPplAhLhGsphhRspLsppGhhlpLsshspsFh.Ah.lssp.puu..pthss.ttll.......ssGhhpLluhhcphP.ultQRhsLLFPshh-cshs......hPstpsL.h.p.shpaAp+Hsph.ss	.................tlhhtPh.Yhp.ph...ss......s..t.hhN.hll.tapLp...s.t........ss.h.hhlppWphhP.hshh.GsphhRtthscpGhhhtlsshh..p..saL..u.h..ths..psp.....sths.s..p.ll.......ssGhupL.sh.c..P.uhtQRFsLLFPsFl.-chph.........hslt.ol..L..ls.h.htpphsphs.h........................	0	4	7	10
+9315	PF09483	HpaP		Type III secretion protein (HpaP)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are always found in type III secretion operons, although their function in the processes of secretion and virulence is unclear. Hpa stands for Hrp-associated gene, where Hrp stands for hypersensitivity response and virulence. see also PMID:18584024	23.30	23.30	25.40	25.40	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.24	0.71	-4.34	11	81	2012-10-01 19:58:36	2007-05-03 13:00:00	5	2	68	0	15	85	3	190.60	33	77.85	CHANGED	sPss....PA........cssppuhstsphhpsuhpsuPsspshPsps........h....sps.psAsss......sssPps.....pssscs.pstsDu.stpshutstsuc.......h.pspchsthlcplAtclAtFCussslhtuGp.WplplslDPslLPposLtLsLS.apLoLRF.....cosss-oRcLlspHtssL+tpLcs....thsusRslpI-Vs	........................................t...s.PA..........pupcpsF.hsphhpcu.h.ph.uPsstshPsss................h....spscc.sAsss......sssP.h........sstcs.ts..Ds.sptuhuRshAut....................htppp+hshhlctLAtclAtFCuusAlhsuGp.WEspLslDsplLPpTsLaLtLS.apLuLRF.....-sscs-oRcLLhsHpstLctpLcs....thusshsIpl-V..................	0	3	7	10
+9316	PF09484	Cas_TM1802	cas_TM1802; 	CRISPR-associated protein TM1802 (cas_TM1802)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	22.50	22.50	23.10	23.40	22.00	22.40	hmmbuild  -o /dev/null HMM SEED	593	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-13.15	0.70	-6.03	16	118	2009-01-15 18:05:59	2007-05-03 13:06:51	5	2	108	0	59	118	6	501.70	18	87.54	CHANGED	MlpulhplGchhlp..scutpphph..........l.p.sptushtplLhlshsscpsplp..hhht-EhspcshpcaLahspussssu...hssTsphs.......................c.hcphtpKlpphhpph...h..............t+.c.hlp....................................................slcphlpcphcphlp-h.......shcppcsslholph...sschhhsp..aptahcthlpthppphh.....tKps+ppul.CplCscp.stlhuph.p...aKaYTsDK.sFss.shsppstaKshslCpcChhpL.tGcpalcppLssphh.uhc..halIPphlh........phcp.lccIhcphpphpshp......tslpppE--Ihphlpppcp...hhhshLF.acpsp..usa+IlhhIcDlsPSRhccIhcttc+spptht...................................phsLspIhhhh.......pp.spsspsKpaLplhsuIFsG+.lshchLlsphhptlRppah...............cstththhshpuhhlltFLpclshLp.......tshphcpspht.......pp-lcpFh....pphhpss.KpAlFLLGlLhscllphQa.........tcppsKsalsK..Lph.thsppclhplhs-lpsKLppY.......tt...ppY.hcplhtphtchhhpuhssWpLopDEhsFYhl.Ghohup	..................................................................................................hlt.h..lGp...t...t........................................ph.hhhhlth...tt.tth..........cpht.tpphtphh....a......httsss.ss...h...s..s.pht................................p..pth.thl.phhp.h...................................p.t.hhp....................................................ph.....phhtpt..hpphhpc..................t..tpp....h.hh.slth.......ssp....h.s....h..ahphh...ht.httt.........ttpt....tpth..CtlCspp.ptlhspht........apaaohD+.sahs.thp....ppphh..+shslCtpCh.tl.tGcpal.........pp.p.........L.phphh..uhp......hhllPphhh...........pp.ht..plh..pth..pphh..pht..........ph.t.cc..clhp.hp...p.pp.......h.hshlF.hpptp...st.+lhhhlpDV.PS+hpplh..pth.pp..hpphh.....................................phshttlh.hh...............tpt...p.h.Lp....lhpt....lhptp.lshphlhp..hhpth.....p..hh.......................pt...h.........hh...p.h.hhh.alpphshlp.....................t..h...t.......................p.hppah....tth.h.ss.cpu.hFLLGsLhstlhphQh................ppptspPhhpp..l.phht.hsppclhplhsclhsKlppY........pt......htth....hctl.htph..pphh...p..t.......t....pa.phs.pEh.FYhh.Ghsht...........................................................	1	23	43	53
+9317	PF09485	CRISPR_Cse2	CRISPR_cse2; 	CRISPR-associated protein Cse2 (CRISPR_cse2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	22.10	22.10	23.40	22.80	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.94	0.71	-4.15	58	642	2009-01-15 18:05:59	2007-05-03 13:07:14	5	4	627	2	120	399	12	146.00	32	78.32	CHANGED	uspApLRRutshsss...........h..ha........hhp..h..t............ptpppshhhlAulhAttppt.....................................ps.ut.....slGpsht.hhttstt.............sss-tRFppLlpus..........hcplhppLRpllphlc..sp....lsaspLscsLhtWpppp..............ptlptcWupDYa	...........................................................Gt+AsLRRusssscs..........phscua.......Lhhpstp.hh.pt...............phc.hsAlsls..AulhAphcthcc...............................................................ppshus.......pLuts............................hsc.tRFs+Lhssc.........ss--LlcpLRRhVcLLs....us........lshssLA-slapWspcpp............s-hlRlRWAh-YY.................	0	34	87	105
+9318	PF09486	HrpB7		Bacterial type III secretion protein (HrpB7)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.89	0.71	-4.30	6	92	2012-10-01 21:16:01	2007-05-03 13:20:05	5	1	73	0	16	91	1	149.70	35	85.75	CHANGED	RRspsacsLlpt+sRcscRlpscLustRstLppssstLtpspspscApsscLssasuplDshsusGushsl-shLppccaRssLh-pputAEpttstAptuLputtspluuhppcluR.cApl-lhs-+tcplcRAt-AttEsAp-EEs.EAlluhRh	...............cpttsapsLhth+spctcRhptclpshRtthptstttlspsptpsctppsthsthstplsshss.ssushs..lsshhtpccaRssLh-cpttAEpppAthcsslputtcpluuspppluR.pApl-lsc-+hcplcRut-AttEsAp-EEh.EullAtRh............	0	3	6	10
+9319	PF09487	HrpB2		Bacterial type III secretion protein (HrpB2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow group of species including Xanthomonas, Burkholderia and Ralstonia.	25.00	25.00	51.70	51.20	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.47	0.71	-3.90	9	93	2009-01-15 18:05:59	2007-05-03 13:24:07	5	1	73	0	16	60	1	116.90	38	89.29	CHANGED	ussosAhsPsss.....sstpLss+FpALMpsusshPsuhptscs.Shlu+lVtppDsulRpsssclthhsppAsphohp-l..sAtslclphEhsuhphchpsphuVspSuKsAlpTLMKNQ	............................hss.AhsssAs.....sstcLssRFpALMpsAsstPsttppsts.Sslu+lVsspDstlRpss-clsshshpAsphohpEh..sApsl+lphElsuhphchpsphuVspSuKsAlpTLMKNQ	0	3	7	10
+9320	PF09488	Osmo_MPGsynth	osmo_MPGsynth; 	Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of examples of mannosyl-3-phosphoglycerate synthase (MPGS), which together with mannosyl-3-phosphoglycerate phosphatase (MPGP) EC:2.4.1.217, comprises a two-step pathway for mannosylglycerate biosynthesis. Mannosylglycerate is a compatible solute that tends to be restricted to extreme thermophiles of archaea and bacteria. Note that in Rhodothermus marinus, this pathway is one of two; the other is condensation of GDP-mannose with D-glycerate by mannosylglycerate synthase.	20.20	20.20	21.50	127.70	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.23	0.70	-5.78	15	56	2009-01-15 18:05:59	2007-05-03 13:38:18	5	4	53	12	32	53	9	385.70	44	87.68	CHANGED	lEhPp.sEpFGuVpIH.-VQ+VlE..LDoG........s.ttpssslpslspccLpclhpchAIVVPsKsEcl+LLEGVLpGIPH-ChlIlVSNSpRps.hDca+hEh-hlcpFsphTc+pllllHQKDPsLApAFp-sGYsslLsscuh.....VRsGKuEGMIlGhLLAKh..hG+cYlGFlDADNYlPGAVpEYV+tYAAGFsMu..............cSPYoMVRlpW+aKPKVscss.lYFcKaGRVSElTN+aLNtLlSshouFET-..........lIpTGNAGEHAMohcLAcpLsauoGYulEPYchV.LLEcFGshhts.tps-shppG..................................................lEIhQIEThNPHlHE.-KGs-H.lpcMlhsSLusIYH..................................S+Lss.........ctl+pcILc-L.....ptpshlspt.--PPpPhlhPPltplDlctFtchlc	........................h.EhPphsEhFGsVcIa.-lQ+Vlc..LDos...............sttsts.slpslsppslpcllpchAIVVPhKsEcL+Ll-GVLpuIPHcChIIlVSNSpRt...-pa+hEhDhlccFsphTc+phlhlHQKDPuLApAFpcsGYsclLs.csGh...........VRsGKuEGMllGllLA+h..hG+cYVGFlDADNYlPGAVpEYl+sYAAGFtMu...................cosYoMVRlpW+aKPKlspsp..laF++aGRVSElTN+aLNpLloshouFE..Ts........................llpTGNAGEHAMohcLA.hLsauoGYulEPachV.LLEpaGthhs...ttp-shppG..................................................VEIhQIEThNPHhHE.sKGc-H.lccMlhsuLuoIYH..................................ScLss.........-pl+pclLc-L.....ptp..shlpps.cEPPpPhlhPPlpplDlctFhchl.............	1	7	18	24
+9321	PF09489	CbtB		Probable cobalt transporter subunit (CbtB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localisation with a protein (CbtA) predicted to have five additional transmembrane segments.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.92	0.72	-4.06	20	220	2009-01-15 18:05:59	2007-05-03 14:19:16	5	1	217	0	69	157	46	56.40	39	87.85	CHANGED	sspsssssspu.sclhtssuAshLGhsllahsGFuphsslHNAAHDsRHusuFPCH	........................................hs...t.shshs.tplssulsuhlL..G...shL...lYhsG........aup.......s.......sh........lHsuAHDsRH.u.hG.FP.CH	0	12	37	53
+9322	PF09490	CbtA		Probable cobalt transporter subunit (CbtA)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of five transmembrane segments, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localisation with a small protein (CbtB) having a single additional transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site.	22.20	22.20	22.70	24.30	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.60	0.70	-5.04	25	417	2009-01-15 18:05:59	2007-05-03 14:20:37	5	1	375	0	137	384	69	223.70	30	92.26	CHANGED	Mhp+llhuAlhAGllAGllsshLQhhhlpPlILcAEsYEsush...................sH.tupu................................suuHs..Hstt......s.ht.tsGhp....RshhT....hsuNllsusGaA.LlLsuhhult.t...stsssppGLlWGlAGFsuhpLAPulGLPPElPGssAAD.............................LssRQhWWluTlsuTAlulsLlAFupshhhhhlullLllsPHllGAPp........P-shsussPspLuspFssAuhssuhshWssLGlluuahapR	................................................MhtpllhpuhhAGllAGlLshshthlhspPh...l.pA.saEputs.......................pttutu...............................huscs...ct...............tstcshp....................Rssts....hhusllhusuh....u..Lhhssh.sh.h....h....s........th....ss....ttt.u.l....hhuhuGFhslhllPsLthPsp.Pu..sus.s.-.................................L.s.tR..h...h....Whu.....o.l......s.......u..s...u..h....u...lh.....l...........l.............................................................h.....h.........h.u....l.........s....h...l....l....h...P...p......l.....ht.....s.....Pp............t...h..s.shPusLhhpFtlASlusphlhWsslGLshGhhhp...............................................................	0	27	74	108
+9323	PF09491	RE_AlwI		AlwI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the AlwI (recognises GGATC), Bsp6I (recognises GC^NGC) , BstNBI (recognises GASTC), PleI(recognises GAGTC) and MlyI (recognises GAGTC) restriction endonucleases.	19.70	19.70	20.00	19.90	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.48	0.70	-6.00	18	173	2012-10-11 20:44:45	2007-05-03 14:23:23	5	4	152	2	21	155	34	374.30	18	73.57	CHANGED	pplGFlhhc.........t...thlplTcsG+tLls..................p...s.pplFL+pLlKaQlssshppp..........h.hpPahhlLcllpcL...........stlohcEhshalhhhhs...ppphcpllsc..........IhpaRppchttpt....................scchapccphpt..................................ptuhcpphcspt.............................................................shpDYsDsshRah+hTGlhshp....upG+hlplsppcp.cpl-hllpshpp....h......s.ppahphhspsststLsh-......shtpphlpplsthhsphspphtltpht..h...........shsp-plccplpclpc......pKhhpc..........hhplLp.htch.pt................tptPshhEahhhhuhh.tlssththh....NhphDs-shPhssAsG..stsDI.h.......ascathllEVTLscuppQp...phEupPVsRHlschtpch.....scshaslFlAPpIcssohppFhht.h.........t.ttthtIhPhslppFhph	................................................hGhh..t...................h..lot.Gphhlp.....................ph.p.haLptlhphphsssh................h.Phhh..llplltch...........t.l.shc-h.hhhhhh........ppphptlhpp..........IhphRpph.t...p.........................pp.h.pt.ht..............................................................................tp.hph.t.......................................................................................................hp-h.D...hRhhphTslhph.......t.sphh..h....t....hp.l.lpphtt.................h....t......l.hp...........h.......p...................................ph..p.h.p.h..hhp......tp..pp..........hhphl...................................t.P.hhhEah.hhhhh..h.t..........shph-sphhPh.pAsG.......s......sDl.h.........tph..hlEsoh.ptppQ....thEh.sl.RHh..hphh.p........h..hslFlAs.lptsshp.h.....................thtIhshth.ph...h...........................................................................................................................................................................................................	0	7	17	18
+9324	PF09492	Pec_lyase	pec_lyase; 	Pectic acid lyase	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.	19.80	19.80	19.80	20.10	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.00	0.70	-5.24	51	198	2012-10-03 02:33:51	2007-05-03 14:24:54	5	14	122	5	65	232	27	282.70	34	61.02	CHANGED	QpssGGWsKN......hDhstshsttpttth...............httttp...puTIDNsATssplpaLA+lapts........pst...+a+sAhh+Gl-aLLsAQYs.NGGWPQ...................aYPh.ppu.......YpsaITaNDsAMlsVlplLc-lupspssa.t..hls.psppt+uppAlp+Gl-sIL+sQl.h...sGp..hTsWsAQHDppTLpPstARuYE.sSLousESsuIlcaLMsl.pPo...scllpAlcuAlsWhc..ps+lsGh+h.phts............p.hhltc..susslWARFY-lsTN...................+PlFssRDuh.......h+asls-lptERRsGYuWasshspcll	..................................QpssGGWsKs.......hchssthstpphtph.....................hptttph....puTlDNsATssplpaLuclYpto........psp.......+Y+sAhh+GlcaLL.puQYs....N......GGWPQ............................haPh.tts.........................YpspITaND.s.AMsp..lhplLpplhpt.pssat.................hls.tthp....t+...sppAhs+Gl-sILcsQlh....s..Gp...hTsW.stQaDph.TL......pPstARuYEhsSluusESssllphLMslspPo...sclhpulcuAlpWhc..ps+lpGhphpphts.............t.hhl.........s..susslWARFY-lpTs...............................................................+PhFscRDG.h........hphs.ltclstERRsGYuWYss.stpl.........................................................	0	34	57	62
+9325	PF09493	DUF2389	CHP02450_Tryp; 	Tryptophan-rich protein (DUF2389)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are small hypothetical proteins of 60 to 100 residues from Cyanobacteria and some Proteobacteria. Prochlorococcus marinus strains have two members, other species one only. Interestingly, of the eight most conserved residues, four are aromatic and three are invariant tryptophans. It appears all species that encode this protein can synthesise tryptophan de novo.	25.00	25.00	32.30	32.20	21.00	16.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.12	0.72	-3.70	57	214	2009-01-15 18:05:59	2007-05-03 14:45:43	5	3	201	0	79	203	221	60.10	36	70.83	CHANGED	sSKWTuspshs.tp+HFhlsphthcc.ctphlc..hlpsl.scpphplsWp-L+ssspWppGWp	.h.SKWTAspshs.tp+HFhVsphp.....tcc.....csshlc..hlpul.spp....phhlsWpp.L+DsshWptGWp.	0	15	45	65
+9326	PF09494	Slx4		Slx4 endonuclease	Wood V, Coggill P	anon	Wood, V	Domain	The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals.  Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates [1].	21.30	21.30	21.40	23.30	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.11	0.72	-4.22	57	215	2009-01-15 18:05:59	2007-05-03 15:16:06	5	8	193	0	153	225	0	65.60	27	7.08	CHANGED	lhptlpphlc.................ppPs....hac+ILhY-PItLc-LtshLp....tth....clststl+pahDppuIshphp	..........................................................hptlpphlp.................spPs....hac+ILhY-........PI.Lp-LtshLp.............ssl.....clshspl+cahDspsIshph.t................	0	39	67	117
+9327	PF09495	DUF2462	UPF0390;	Protein of unknown function (DUF2462)	Wood V, Coggill P	anon	Wood V	Family	This protein is highly conserved, but its function is unknown. It can be isolated from HeLa cell nucleoli and is found to be homologous with Leydig cell tumour protein whose function is unknown [1, supplementary Table I].	21.80	21.80	23.00	22.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.85	0.72	-3.25	16	199	2009-01-15 18:05:59	2007-05-03 15:21:16	5	6	183	0	143	182	0	80.70	31	76.49	CHANGED	MAQGthKh..KAKsssssp........+Kpps.++.usRhItPKKtshhptpKLpKhhouulpspsE+.lsp+A.....G+LpLlK...usp+cp	........................MAQGph.K...........Ku+tssssp.........tpppp..u.s..+K.Gs+sIt.PKKs.p..l.h.p.p.pK.lp....Kplosulsp.psE+tlsp+A.....G+LpLlK...ustc..h...................	0	41	69	114
+9328	PF09496	CENP-O	Cenp-O;	Cenp-O kinetochore centromere component	Wood V, Coggill P	anon	Wood V	Family	This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere.  It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human [1][2].	19.60	19.60	19.80	20.00	19.00	18.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.03	0.72	-3.75	28	202	2009-01-15 18:05:59	2007-05-03 15:21:40	5	1	164	2	135	187	0	88.50	31	28.93	CHANGED	LGlRh-lhsc.pupFhcPYYllL++hsp.tp.....................hpla+HTlPsaIPlcpltpph.Lss.............................tpp-lppFscclpcpLssaphRpcthptL	.........lGlph-l.st.pGpahcsYYllLpp.pt..tt.......................................lpla+HTlPsFI..PLcpltpca.Lss......................................slppFlcplpcpLsuaptR+tthp.L...........	0	25	60	100
+9329	PF09497	Med12		Transcription mediator complex subunit Med12	Wood V, Coggill P	anon	Wood V	Domain	Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator [2].	25.00	25.00	29.80	25.00	24.90	19.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.07	0.72	-3.99	28	294	2009-01-15 18:05:59	2007-05-03 15:21:57	5	9	223	0	201	300	0	62.60	40	3.55	CHANGED	sFp.PsRVTLocs++-sWLp-LAssshsLpcLu+p.lPHGh+p+pLl-thh.............................................ppplPlpRAlWhlK	..............Fh...hsshopsphcsWhpDLAs.stPLppL......u+...........p.lPph....++cplhshlh.............................................phsVPlhRAsWLlK..	0	54	94	155
+9330	PF09498	DUF2388	CHP02448; 	Protein of unknown function (DUF2388)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of small hypothetical proteins, about 100 amino acids in length. The family includes five members (three in tandem) in Pseudomonas aeruginosa PAO1 and in Pseudomonas putida (strain KT2440), four in Pseudomonas syringae DC3000, and single members in several other Proteobacteria. The function is unknown.	25.00	25.00	26.60	31.10	19.30	18.80	hmmbuild  --amino -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.29	0.72	-4.34	32	301	2009-09-10 15:05:37	2007-05-03 15:32:04	5	1	84	0	73	218	5	71.80	49	68.29	CHANGED	ulssSstsTossoooh+.DpKlVlsARDDAAoFVASsGsIRGApLEAALpplRpptPpL.pASDhpLApAILuh	...........................s.hhposssTSssoooh+.DsKllhsARDDAASFVASsGsIRGApLEAALpplRppsPph.pASDhpLApAILA.h..	0	7	14	47
+9331	PF09499	RE_ApaLI		ApaLI-like restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes R.ApaLI and R.XbaI restriction endonucleases. ApaLI recognises and cleaves the sequence GTGCAC.	25.00	25.00	26.30	25.90	22.80	20.20	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.25	0.71	-4.92	6	327	2012-10-11 20:44:45	2007-05-03 15:36:43	5	1	171	0	9	42	2	56.80	51	84.36	CHANGED	slpcpI+hLAppYAscLpppltpRshEMpsDDp.................................................SHYLIY...........RVLGlsh-EGcLIDhYQNpGRFLYKYAGSFLEE..AThLCFKctF........................scu..u+t+VtNTpGp+PKsFEIDCLl.....sspAaEIKWR..DATTDGDHIsKEHTRl+VlpstGYhPlRIMFYYPsRsQAhRIQpTLcTLYpGVGGpYYhGDuAWsaVcccTu	..................................................................................................................................................................................................................................................................................................................................................................	0	6	9	9
+9332	PF09500	YiiD_Cterm	yiiD_Cterm; 	Putative thioesterase (yiiD_Cterm)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry consists of a broadly distributed uncharacterised domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain Pfam:PF00583.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.80	0.71	-4.62	47	840	2012-10-02 20:54:35	2007-05-03 15:37:05	5	5	832	4	122	505	74	141.30	61	49.49	CHANGED	tppLpphh+ppIPloctMulplhpasspplplsAPLssNlNh+sThFuGSlaoluTLoGWGhlaLpL+-tslp.GcIVlt-upIcYhtPlssc..hApsphs...................shss.lspLpptp+ARlplpsplhsssph.......supFpGpaVsh.	........................CuQLQQAWY-HIPLSEKMGVRI....QQY..T.GQ+FlTTMPE.s...G...N.Q.NPHHTl..........FAGSLFSLA.TL.TG.WGL.IW.Lh.L.RERHLG....G........TI..I..L.A.D.AHIRYS+PIoG+...PpAVADLu...................uLSGDLDRLAR.GR..K.ARV.QhpV-la.G.sE.ss.......GAlFEGsYlVL.P...............................	0	22	48	86
+9333	PF09501	Bac_small_YrzI	Bac_small_yrzI; 	Probable sporulation protein (Bac_small_yrzI)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are very small proteins, about 47 residues each, in the genus Bacillus. Single members are found in Bacillus subtilis and Bacillus halodurans, while arrays of six members in tandem are found in Bacillus cereus and Bacillus anthracis. An EIxxE motif present in most members of this family resembles cleavage sites by the germination protease GPR in a number of small acid-soluble spore proteins (SASP). A role in sporulation is possible.	21.20	21.20	21.90	21.40	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-8.07	0.72	-4.05	13	422	2009-01-15 18:05:59	2007-05-03 15:43:11	5	1	124	0	34	156	0	46.00	49	98.60	CHANGED	MTFplFFLTITIQK+p...hSpsElcpcpQhcplh-Eh+-Rp..spYhs+h	.MpF+lFFLTITIQKpp...lSpsEIh+-pQIcphMD-lKERQ..upYho+L.........	0	4	21	22
+9334	PF09502	HrpB4		Bacterial type III secretion protein (HrpB4)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.	21.60	21.60	21.80	55.80	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.56	0.70	-5.15	8	89	2009-01-15 18:05:59	2007-05-03 15:43:34	5	1	71	0	15	75	1	211.40	37	94.56	CHANGED	ssApstthARhLpcapsplssLs-alD....s.uWLpsssulus...u+usuhRsthphh.......h.+sh.shtGhssPoLssL-stAsR.................LAVLstssLlpVLpuRALhsRsssLRpCI-RspRotLpptlGPtsh.hh.s.tt....-AsptcsustuhsPL......sh-ucshAWl..GaRthppDGsWPssu.lh+llRLAL...Ptu.........u.sPpLsPhAusu...sucphLuALPoLaPE	...........................s.ss.hpttAthLptapsshtphschlc....s.uWhs.sls.uls.....upAsshRsAhphh..........h.csl.....Ghu...tsolsuLtthA.s.R....................LAlLshsphh+VLthRALhhRpstlR+sIDRtphs+LtshV.......Gssssphh...................-AsRtp.......tpst.....shsPL.....sth-A..cslAat..GWphhpsD..ss....hsss...........u.sh..+...llRLuL...Ptu.............s.ssh.LsthA.ucs..............sutthlstLPoLhPE...	0	3	7	10
+9336	PF09504	RE_Bsp6I		Bsp6I restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the Bsp6I (recognises and cleaves GC^NGC) restriction endonucleases.	25.00	25.00	29.40	71.10	21.00	24.90	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.21	0.71	-4.82	3	17	2012-10-11 20:44:45	2007-05-03 16:24:33	5	1	17	0	0	10	19	169.30	53	94.55	CHANGED	MAYKKFGYIEIDDARI--TCDAYFKWKDLNoYIKNTSSRGINMPDAISEPMGCYCLGYLWNRGoEVGDATDPcTNAKIEFKATSKFDGDLSSFGPKTVFDNLVFLRFNLD-NcLYIYDLsINSE-LcKYPANKTQTIQDQKAhGRRPHVSLQKLFVEA+DlcPDIIFDIRRCRIIEDNR+	.....uDsh...........DKs-FEhlp-lahcWhhhNp+lKSluuRGlNhPDVFSEuLhChAhNhlRosGTuh.hDslhcDTsctVQVKuuS.hssDsTSFGPTSsaDlLYFAcFs.ssc.-hhVhhhKIpsDDlYNlslN..KsETFKDQQAQGRRPRFSIQSsII+uKcLhPltslNI...........ITGc.......................	0	0	0	0
+9337	PF09505	Dimeth_Pyl		Dimethylamine methyltransferase (Dimeth_PyL)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of dimethylamine methyltransferases from the genus Methanosarcina. It is found in three nearly identical copies in each of Methanosarcina acetivorans, Methanosarcina barkeri, and Methanosarcina mazei. It is one of a suite of three non-homologous enzymes with a critical UAG-encoded pyrrolysine residue in these species (along with trimethylamine methyltransferase and monomethylamine methyltransferase). It demethylates dimethylamine, leaving monomethylamine, and methylates the prosthetic group of the small corrinoid protein MtbC. The methyl group is then transferred by methylcorrinoid:coenzyme M methyltransferase to coenzyme M. Note that the pyrrolysine residue is variously translated as K or X, or as a stop codon that truncates the sequence.	25.00	25.00	529.60	529.50	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.64	0.70	-6.22	3	16	2009-09-13 14:57:56	2007-05-03 16:31:52	5	1	8	0	12	25	14	459.20	77	99.76	CHANGED	MATEYALRMGDGKRIYLTKEKIluEIEAGoANAADLGEIPALSuDEM-KLAEILMMPGKAVSVEQGMEVPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMTHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIsEAWESMEHAADHLTRDTVWVMQKLFASGADGVNFDTTAAAGDGDMYGTLHAVEALRKEFP-MYIEVGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSAWNLARAVTFIKEAVKASPIPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEVAGVDGIXIGVGDPLGMPISHIMASGMTGIRAAGDLVARMEFSKNMRIGEAKEYVAKKLsVDsMDLADEHVMRELREELDIGVITSVPGAAKGIAAKMNIEKLLDIKINSCELFRKQl	.....MATEYsLRMGDGKRlahoK-+Ihp-lEAGhusAuDLG-IPsLSs-Eh-KLAEILMMPGKsVSVEQGMEVPVTHDIGTlRLDGDQGNSGVGIPSSRLVGCMhHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKtFKIpEAhESMEHAA-HLTRDTVWVMQKLFASGADGVNFDTTuAAGDGDMYGTL+AIEALRKEFP-MYIEAGMAGEhVLGMHGsLpYDGVTLAGLWPHQQAPLlAKAGANVFGPVCNTNTSKTSuWNLARAVTFhKAAVcASsIPCHVsMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPhGMPISHIMASGMTGhRAAGDLVARMpFSKNMRIsEAKEYVAKKLsV-hMDLuDEaVMRELREELDIGlITSVPGAAKGIAAKMNIEKLLDIKINSCpLFRKQl..	0	4	7	7
+9338	PF09506	Salt_tol_Pase		Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase)	TIGRFAMs,Coggill P	anon	TIGRFAMs	Family	Proteins in this family are glucosylglycerol-phosphate phosphatases, with the gene symbol stpA (Salt Tolerance Protein A). A motif characteristic of acid phosphatases is found, but otherwise this family shows little sequence similarity to other phosphatases. This enzyme acts on the glucosylglycerol phosphate, product of glucosylglycerol phosphate synthase and immediate precursor of the osmoprotectant glucosylglycerol.	25.00	25.00	248.60	248.30	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.17	0.70	-5.91	16	45	2009-09-11 09:42:30	2007-05-03 16:32:15	5	1	45	0	16	45	195	380.80	52	93.38	CHANGED	pcLLIVQDLDGVCMPLVKDPLTRpl-scYVpAsupLpscFsVLTNGEHEG+RGVNRlVEpALuspppspccGLYLPGLAAGGVQaQDRaGplSHPGVS-sElsFLAtlPp+McshLtppLsslhPpLoscplpphhptAlLDTplSPTINLNuLFull.sDVppQ+pLQthlpclMspLlspApupGLcsSFFLHlAPNLGpctsGpEhlK.AstsDlGTTDIQFML+GAlKEAGLLsLlN+aIup+oGpuPLG-sFNVRsAP+sHpuLLsLC+cpIss-pMPhLVGVGDTVTSph..sssupuWLRGGSDRGFLTLlQcLGppaspsNRVVhVDSSpGEV.sRPSlpDssLpGIS..........DP-DPL+FDllhsuGPcpYlsWFppLAp	.pNLLIlQDLDGVCMsLVKDPLTRpl-scYVpAspphpscFhVLTNGEHtG+RGVNRlVEpALGssshsppcGLYLPGLAAGGVQaQDRaGplSHPGVScsElsFLAtVPpthcstLpphlsshhPpLus-plpptlptoVLDspsSPTlNLNuLFsllpc........-sphhppLQphhppLMspLltcAtupGLtsSFFLHlAPNLG+Dpp...GpEhlK.AptsDsGTTDhQFML+GAlKEAGlLsLLN+ahtpRTGphPLGcsFNsRsAPpsHpsLLcLs+pplsscpMPhlVGVGDTVTSps...ss..s..stsahRGGSDRuFLpLlQcLGptaspsNpVVaVDSSpGEV.sRPslphss...........l.pGIo.................Ds-DPL+hslshPsGPcpYlsaFpplA.....	0	2	8	14
+9339	PF09508	Lact_bio_phlase	CHP02336; 	Lacto-N-biose phosphorylase	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolism. The protein appears to be a carbohydrate-processing phosphorolytic enzyme (EC:2.4.1.211), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolism of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.	26.60	26.60	27.20	77.50	24.40	26.50	hmmbuild  -o /dev/null HMM SEED	716	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.52	0.70	-13.24	0.70	-6.87	7	288	2009-01-15 18:05:59	2007-05-03 16:33:53	5	3	255	18	27	215	17	673.60	54	98.37	CHANGED	GRhTlPs-sshtppshELhpRWGADAlRDsDGTchs--lhphssKlYSTYhssRsDpsWAptp.-ElpQhYLMop.ssAhS-sh.pIsLhcGaac-QhhsssspD.ccWWEVlDRTTupVlss-pWsaDtpstpVhlpsspsaHcYTVoFLAahIWDPlpMYNalTNsWtshcHph...saDshpPcTppalhpthccWlc-pPpsDVVRFTTFFapFTLsaspht+E+aV..DWaGYusoVSPhALEpFEKEhGY+LpPEDhlDpGaYNssaRVPsKpa+DahsF.pcaVschsKcLV-lsHpsGKEAMMFLGDpWIGTEPatctFpclGlDAVVGSVGsGsThRhIuDIPGV+YTEGRFLPYFFP......DsFhEGGDPlhEApsNWlpARRAILRpPlDRIGYGGYLpLAspFP-FlDhlEcIssEFRcla-shpGppsh.shh+VAVLNsWGphRSWtsphVtHAlah....+psYSYhG..llEuLSGhPh-VcFISFDDIhcp.Gl.c-lcVlINsGsusTAaSGGphW.c-tclsutl+pFVtpGGGhIGVG-P.oAppapG+aaQLAcVLGV-+EhGholSpc+Yshphp.pHFlT.t-hstc..............................lDFGEuhpslYshss.splLttc...........ttplphAVNpaGcGRuVYluGlPYShcNuRlLhRulhWAuppEpphppahSoNhpsEVAhYscss+hsllNNT.-.QpTslhps.ucs.slcLts.-hhWhsl	.................................GRlTLPs-psh.tpstELh-RhtADAlRsSDGTcLP-.lpcL.s.sKIYsTYassRuDp-WAptHPcElpphYLMSchssAh......u-s..sIsLMpsaas-QltPsscsDsc+WWpVIDRTTG-VlssstWph-t..tst.s......V..slppAtshH.YTVuFLAh.hWDPspMYNalTNsWt.Dc..pcI...PaDlRpPpThpalhctLcpWLt-..sPpVDVVRFTTFFYpFTLlasppu...pE+..aV..DWFGYSASVSs.AlEtFEKchGYtLpsEDhlDpGaYNSsFRVPpKpa+DalsFQpcFVsphs+ELV-hsHtsG+EAMMFLGDpWIGTEPYG.tFtphGlDAVVGSVGsGsThRhISDIPGV+YTEGRhLPYFFP......DsF.a-GGDPV..tEApssWlsARRAIlRsPlDRIGYGGYLSLAhpaP-FVDhlEclssEFRpIassstGppPh.ssh+VAlLNsWGtlRSWtsaMVAHALaY....+QsYSYhG..lLEuLSGhPhpVcFlSFDDIhp..Glscsl-VlINsGsAsTAaSGGp.W.tDtclsoslRcFVtsGGGhlGVG-P.oAh....t..p..GthaQLuDVLGVD+EhGasLSsc+ash..........c..hsccHFlo.tDl.s..s..c..............................lDhGEGh..sl.ashsssTplLttc.......................cp.pVpLAsNpaGpGRuVYluGLPYS.pNuRLLhRAlhWAu+cE-th.pp.WhSosspsEVssYPcss+hhVlNNoh-t.sTsVhss.sss.pclchpssthhWhc............................	0	15	19	23
+9340	PF09507	CDC27		DNA polymerase subunit Cdc27	Wood V, Coggill P	anon	Wood V	Family	This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterised by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.	24.40	24.40	24.40	24.60	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	430	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.68	0.70	-5.25	21	329	2009-01-15 18:05:59	2007-05-03 16:34:30	5	7	232	7	213	324	1	344.60	20	88.93	CHANGED	+lVTY+hLScsLsVHsNpAKQMLY-ahcpcppcps.splaATYlloGp.hsst.sspp...................................................lslVcE-cLEss+u+hspshShalYSlQpshLpDsssLhsssh-hlpp.....spp.sthpstphs.htstplppppt......s.ssts....psshsuc.s...............stcsspuhhs.thpscppspspspp+sppstpscttss......pssstKh.s.s+ushhssFhptpsppKhttp.tstpsstpE.....ppt.psspshs.pcpss.......cppcps..hcs...................p.sspppppp.......................EscKc+.cc+l+phhpDc................s---............ss-SP.sppcspsssPs..........cp-.ptppsphpst..........s+RRtRR+V.hKpcThhD.-EGalVTcch.p.EShS-sEss.s................PsKppsssp.ss..ss...........spcsK.............sttttQusIMSFFpKK	...........................................................................................................................loa+.lu.thtlp.s.AK..p....h................L.pahpppp.............splpssYllpG..h.p.tt...............................................................................................................lhl..lp.-..p.pLpth..h...t.pht...h..o...hplYSl.....p..........s...h..p.-.......s......l.....h.....s....s....t...........ph.t................t......sh...t...tt.h..s.h....s...t..pptpt..................................sh.stt............................................t...pt....t.....t...p...pt.t...ps.p..ttp.ttp.....tttp...st.......................ps.s.t.c.......................tp..ss.h.tshhtttsh...ttht........t...tt.....tp.....................................p........t..h..p..p..........p.ttpt...t..............................................ppppppp........................................................................................cp.ppc......ccch..+..........p.ss...................................sp-p..................pp.......t....p....t.p.................................ptp........t.p................................ptt....t.+..+pl..hp..ppp..hhD.-c.G.hh.........VTpp.....t.ph..s.ppc..............................................p..tsh..t.........................................................t.t.p.......................................tt.t..Q.ss....lhuFFt+....................................................	0	66	111	175
+9341	PF09509	Hypoth_Ymh	Hypoth_ymh; 	Protein of unknown function (Hypoth_ymh)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry consists of a relatively rare prokaryotic protein family (about 8 occurrences per 200 genomes). Genes for members of this family appear to be associated variously with phage and plasmid regions, restriction system loci, transposons, and housekeeping genes. Their function is unknown.	25.00	25.00	25.50	25.40	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.53	0.71	-4.50	25	190	2009-01-15 18:05:59	2007-05-03 16:38:58	5	3	179	0	48	143	15	120.50	37	43.17	CHANGED	pscslHsclhchsppphhss..pYhcAVhEAsKulss+lRptoGl..stDGssLhppuFu.sc.........pPhLtl..sshpocopcupQcGht.......sLhpGhhssaRNspAHcsc.hp.....hocpDAl-hLuhlSlltRhL	...............p..+tlHsclhpaCcschl.....sc..sYacAVhEAsKulsc+lRpho..Gl.......s....tDGscLlsp......AFs.sp..........pPhLtl..sshpT.coEcuEQcGht.......sLhhGlauuhRNPhAHps+..hp.s......hscpDAL-lLsllShlpR+L.......................	0	15	33	41
+9342	PF09510	Rtt102p		Rtt102p-like transcription regulator protein	Wood V, Coggill P	anon	Manual	Family	This protein is found in fungi. The family includes Rtt102p, a transcription regulator protein which appears to be integrally associated with both the Swi-Snf and the RSC chromatin remodelling complexes, [1].	21.40	21.40	22.80	22.40	20.40	18.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.64	0.71	-4.16	6	33	2009-01-15 18:05:59	2007-05-03 16:40:41	5	1	32	0	20	32	0	128.50	40	65.10	CHANGED	SLIc+AN+.uGYussscpp..HWcY-WhoPs...........KpsEsspp.....P....ss.psp.ppYsFKaKsWl+sssscsh.shhc-ss-.plLDLscFDR........T+hsttspthpspusss....puLohsDIRGAVGGSEuI.......PGhS	................oLIs+AN+..uhYusssscc..pW+YDWYpPs..........................K.ss..usspp.sppp..............ush.pNslEKYsF+YKTWl...+spc.s-p....sLpc-ss-..D.........lLDLp-FDR........Tpcscsss......spsssssusspsspuLosDDIRGAVGsSEuI.......PGhS.............................	0	3	10	17
+9343	PF09511	RNA_lig_T4_1		RNA ligase	TIGRFAMs, Coggill P, Mistry J, Wood V	anon	TIGRFAMs & Pfam-B_49998 (release 17.0)	Family	Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity [1].  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.	26.80	26.80	27.60	27.20	26.20	24.50	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.60	0.70	-4.87	48	347	2009-01-15 18:05:59	2007-05-03 16:41:19	5	16	314	2	157	357	36	216.60	26	33.56	CHANGED	hpuRGLhhp........................psscIlsRua-KFFNls.........EhstTphcsl..pt.......Phclh.KtsG..sll.hshl.........psG....plllsSKpSs...................................................................................................................psspAptucphlpp.....pltpt..........hppls....ctLhppshTslhE...lsssp.pchVlsYspcphsLhLpshstss.....sca.hshs.hplsph.uc..pashpphchh.thss......th......ttph.ssshpt................ct...hEGa.Vlcsps........................................shhaKhKh-t.hh	................pARGLhhs........................pssscIssRuacKFFNls........................Eh..t..t..oph.pp.l....tph...........PhclhhK.NG...sll...l.shl..............psu............plllsSKpSh...................................................................................................................pssau.phucph.l.pp................phtp...........................hpplt.....ptl.hctshTslhE...lsssp.-..cH..l.lt...Ys.p.pp.hhl.hLtshNhps.......sca.hshs..tplpph....scpauh.....p.....ps.....phh...hhps....hp....pltt.hh........pph....ps..s.hps.................cp......hEGa.Vlpspp........................................shhaKhKhp..h........................................................	0	64	102	138
+9344	PF09512	ThiW		Thiamine-precursor transporter protein (ThiW)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.	27.20	27.20	27.60	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.90	0.71	-4.38	26	735	2012-10-03 02:46:00	2007-05-03 16:43:36	5	2	729	0	72	328	1	148.20	47	86.38	CHANGED	LslsAlhlAluVllSslhtIPlGhs+shPhQHhlNVluuVlLGPhauluhAhlhullR.hlGsGolLAFPGShhGALLAGl....hY+hs+.+h...hhAslGEllGTGlIGuL.luaPlAshlhG.spsuh...hhahssFhhSolhGulIuahlLhhLp+p	.....LslhuhhIAlsVVLSsI.hpI....tt.hAPhpphVNlLuuVhlGPhYuLAhAhloullRhhhtsh....ssLAhsGuhhGA....LLAGl....FYpa.......s..+...+h......ahuulGEllGTGlIGSl.lua.PlhhhhsG....pst.tl..............hhahspF.hsuolIGohIualllhhLpK.p.......	0	36	52	66
+9346	PF09514	SSXRD		SSXRD motif	Bateman A	anon	Pfam-B_23332 (Release 21.0)	Motif	SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localise to this region [1].	20.90	20.90	21.40	22.20	19.00	20.40	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.43	0.72	-4.64	33	133	2009-09-11 15:10:05	2007-05-03 16:52:11	5	18	25	0	55	155	0	32.80	56	11.21	CHANGED	pssthpVpsWoHRLRERK.hVIYEEISDPEEE--	.......pss++thc.sWoHRLRERK.hVlYEEISDPEEDDp.	1	12	12	13
+9347	PF09515	Thia_YuaJ		Thiamine transporter protein (Thia_YuaJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this protein family have been assigned as thiamine transporters by a phylogenetic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.22	0.71	-4.51	43	674	2012-10-03 02:46:00	2007-05-03 16:53:45	5	2	640	2	112	689	6	171.80	34	87.25	CHANGED	llEhulhsAlAhlLshl...hhphPpGGSlol.uMlPIhlhAhRaGhpsGllsGhlaGlLpll...hu.......s.a..llpshQslLDY.lAFsslGlAGlFtp............................ttt......hhhhhGsllushsRahsHaluGllFaGuYAPcGh......sshlYSllhNGoh.hlsshllshlllhlLhhpts.phhh	............................hlEsAlhsAlAhl.Lshl.....h.h.ths..p..G.h....Sloh...uMlPlhlhuhRhGhtsGhhuG.hl.aGl.Lphl...lG..............sha...hLsss.Qs.l....l..-..........Y.......hl.....AF..........u.h.l..G..h.A.G.l.F.tp.h...........................ttphh.th.hhhl......hhusl...l....ush...s.R..ah..h.Ha.lu.G..l.l.F.a....Gs..Y..A.....Pc...Gh................sshl...YS..h.l.h..NGoh...hlsshllshlllhlLhhs.sph..h.........................................................................................................	0	51	86	99
+9348	PF09516	RE_CfrBI		CfrBI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the CfrBI (recognises and cleaves C^CWWGG) restriction endonuclease.	25.00	25.00	96.00	95.50	24.50	23.30	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.85	0.70	-5.51	5	36	2012-10-11 20:44:45	2007-05-03 17:06:14	5	1	36	0	1	27	2	257.80	52	84.94	CHANGED	MpFc-.........................plh++VIpcVLpGcDYREpl.......lNtlNsEFLDFu......IDFFK-lloAKhpspslsL-WYpcasLuNKu..Pc.-lAI..hsGhNpKTIpNlYGouoKpVVlshupsplchL.sulppLu.csQ--IG.IslKIsY....K-lSVs...LsLcESLlVINALAoK+lsLRGStaSohGKplEKhLMLoLCplhGlc.....E-slsAcsFsKsKutDhDRElDFpL.plcsuKtYRVEVKLMGKGNPE.............SADAVIARsosIFIADTLS-QNK	....................................slp+sIphLL+GKDYREhV.......LNsINsEFLDFA......IsFFK-IlhAKMpDcuIshsWYppashsNK-..sK.-lAI..LsGhNhKTIhNsYGToTKEV.VLDlupsNlcYLh-l.LQsLppss.s-lG.IsIKITY....K-ISVs...LDLcESLlVINALATKKIALRGSAaShlGKRlEKPLMLpLCc+CGlS.....EuaIDAosFpKDK+L-aDREVDFKLYNpD+SKsYRVEVKLMuKGNPE.............SADAVIAR-ocIFIA.TLSEQNK...............	0	1	1	1
+9349	PF09517	RE_Eco29kI		Eco29kI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the Eco29kI (recognises and cleaves CCGC^GG ) restriction endonuclease.	23.00	23.00	24.40	23.00	22.40	21.00	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.10	0.71	-4.93	6	60	2009-01-15 18:05:59	2007-05-03 17:25:00	5	2	56	17	15	56	3	164.70	44	74.26	CHANGED	PcpFpGAGVYALYYsGsasLYcphu.chNchsastPIYVGKAVPtGhRpuRhucNss..uspLasRL+EHuRSIupsusLDlsDFhCRFVlh-hthSshIshhEAsLIchapPlWNosVDGFGNHDPGpGRasQ.....t+SsWDslHsGRsWAs+hss................h.uc..uItcsIppaLcp	...............cpFpGAGVYAlYYhGs.h.shYpplu.chN.R...s.as...t.PIYVGKAVPtGhRput.u.ss..pustLapRLc.EHucSIs.tss......sLc.sDFhCRFlll-...sshIshsEuhLIcha+Pl....WN..............s.....slDGFGNHDPG+GRapp.....t+ScWDslHPGRsWAp+hps................hspohcplhppltpaht.t.....................................	0	4	12	14
+9350	PF09518	RE_HindIII		HindIII restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the HindIII (recognises and cleaves A^AGCTT) restriction endonuclease.	25.00	25.00	66.40	66.20	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.90	0.70	-5.52	5	26	2012-10-11 20:44:45	2007-05-03 17:38:09	5	1	23	8	3	23	3	278.00	34	94.43	CHANGED	NuE.........hl.s........hss-hlKlsuphT.Dac+lss-llptI+KhsccplI-lLpouGhIPEsYcsDSSEEKLFSKhsDALlu-shpchGapApsLsERusAuDVhltsc..sptIVuDAKoFRLSRT..AhNsKDF.KVculcKWRstht.sKDaulVlsPpaQhPssKSQ..lYsQulDpNVLlLSYcHLAaLLcp+-.hss-hh..LWEYpsIFspp.hhN.suKsu+pYWsuINcsllclssct-KtahDphstscctLpphlcccIp.lE.....chEalcpEIs+IhshoREcAIR-LlcchKIpu+lEph.phl+slpcpcl	..............h...................t..phsu..s.-hpphstcl.t.lpp.spptll-hLppsGhIPEshptDSSEEKLaSKhsDsllucshphhGhpupsL.sERusuuDVhshsp..sYtlVADAKsFRLSRT..AKNtKDF.KVpulscWR...p....sKDaulllsPhaQhPsppSQ..lYpQulspNVhlhoacHLAhLlphtt..s.c.....Lh-......tIFst..hh..stcpuhpYWpslNpshhphssphpchah-.hthspctltphhpptI...........cahppEhppIhtho+-cAlptLlpph+lpu+lcth...hcthpp.................	0	3	3	3
+9351	PF09519	RE_HindVP		HindVP restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the HindVP (recognises GRCGYC bu the cleavage site is unknown) restriction endonucleases.	25.00	25.00	26.00	34.60	23.10	20.50	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.83	0.70	-5.53	3	41	2012-10-11 20:44:45	2007-05-03 18:03:25	5	3	34	0	4	50	1	255.10	38	90.73	CHANGED	oWGKNQFNSSFPlALACYMSSKNIpPlYL+LE+.tsIcHupIDVcsVFpIcP.ptpsFFAFEpSY..............................pIKLTAlPDpTTssLsDs..GsEIVIRPDoIVYLAhSlAclhpps.hshhDI..PssschhDWp-sppl.PhhPhhhphL.slhsRhpslQhPhLLQPlWKT.GK.shLtDNCLDIFlWSNlAFsKlFLDASplclNscSITRpcRTsVWLhKMLYDFApsGKINH++TIDcISaNTKNDKAFAuSGMlT+pYMKSPELp+PRIK+cEIKNIILGGGQ+LLSPERRFDAIIlNTPsLF-	.....................aGKN.FssuFP.uLhsah.p.ptlps.Ylhh....p..p..............plppt.lshpplashps...s.tphaasFEt.a...............................hElKLTslPDpsTtphs-p.ausElVlRssol.ahAhSlspth....pp..ph..t..t.hh.h....h....cWsp.tplhshh.phhtslpplhpph.shQpPhlhQPlWKTpGKps.LspsCLDlFlWSshAFs+hhlshu....p.s..p.....pIsR.tRohlWLhKMLhDhsppGphsappllcphoasspsDKAFuhsGphTp.aMps.clppPtI.+pEIppIILssGppLLSPERRFDuhlh.ssspLF.................................	0	2	4	4
+9352	PF09520	RE_TdeIII	RE_MjaII;	Type II restriction endonuclease, TdeIII	Bateman A, Coggill P	anon	Bateman A	Family	This family includes many TdeIII restriction endonucleases that recognise and cleave at GGNCC sites. TdeIII cleave unmethylated double-stranded DNA [1].	23.80	23.80	24.00	23.80	23.70	22.70	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.67	0.70	-5.08	11	54	2012-10-11 20:44:45	2007-05-03 18:10:25	5	1	48	0	19	62	14	233.10	26	89.78	CHANGED	Mulss...tT+NKl+-aLsshlccpLpsY..pt.hp.............ss-sshpPFHtpLlPtslMplt+FERSLsTuLGp.hFEpsA+lIAhspausA.ppYclpsslsptshssIDpllsplc..........+spppppsohsEhlcplpplspsthtEsolV.uDLYlp+cDGpEhaF-IKSsKPNKGQshpshpcLLRlhAlc..pp.tssscsFaAhsYNPaG....p+tuYohshh+thhDhcs.tVlIGpEFWshIGp.suTYsELL-Iac-VG	.......................................................................httlpphlpp.lcph...hpph....................psptt.hP...Fhttll..............st.............-........hhthspF.+ShsTshGpshaEplAphlApspht.s.p.phpht.sp...IspptpppIpplhsplc..........t.ptp.sph.p..ctlct.h..hph....sp.tp....h.psphs...Dl.a.l.p.pp.s.sp..hhh-lKo.....s.....K.P.NtsphcthKpplLphhshh....pp......ptphpsahAhPY.......NPa...........p.psapp.......h..ht..th.h....Dh.-p..plllupEaWshluG.csoY.pplLchapclG...........	0	9	12	17
+9353	PF09521	RE_NgoPII		NgoPII restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the NgoPII (recognises and cleaves GG^CC) restriction endonuclease.	25.00	25.00	35.90	35.90	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.76	0.70	-5.61	4	62	2012-10-11 20:44:45	2007-05-03 18:15:05	5	1	53	0	7	42	7	186.50	42	93.41	CHANGED	M...pNIlsAIhNlspNP.hpLcpa...spS+NRANpMG-uLEEYlKDlFusoh.p.D.sp+.tlauchFSYLGNpNNPPDhIL+sGDAlEVKKIEshcSSLALNSSYPKuKLasssSMIT-AC+sCEcWE.KDIIYsIGTlccpp.LKtLhhVYG-sYAA-splYp+IpspIKtGlpsIsslpFSETpELGRVNRVDPLGITYhRlRGMWGIENPhKVFsYIhph-..csppFNhhAlhpc-KYpSFsspD+hc.huhpNptLtIpDl+IKs	...................NIlsAlhNlhpp......h.tlpp.....pu.sRANphGsuLEpalKDhFut.................................hl+tG.sulEsKKhps...s.ssLsLNSSaPKs.l..ss..l..pth+ttE..pWcpKcllYhlGhh.p..pp..LppLhhVYG..asAptphY.clcppIppul.tph...ss..l.hscTpElG+lpplDPLsho.LRlRGMWtIppPhhV..Fp....lht......ppthphhsll..tcatphspp.c......p...h.tlpch.l........................	0	0	5	6
+9354	PF09522	RE_R_Pab1		R.Pab1 restriction endonuclease	Bateman A	anon	Bateman A	Domain	\N	25.00	25.00	60.20	29.80	18.40	17.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.65	0.71	-4.21	5	56	2009-01-15 18:05:59	2007-05-03 20:02:19	5	2	32	6	4	55	0	116.20	69	53.14	CHANGED	KQKQFIEDNF..MITRERFRSHQFGGMDFELSRISYPLLIHSFDD.NELSEIVIKEQQYGSKTQAMLYFCFSILELKTATPLLNRTAphKEHALLlIHcsNAshFLEMLKIFGLLSQsHHNDVLKILEKIL.QN	..............................KQKQFIEDsF..hIsRERFRSHQFGGMDFEhS+ISYPLL.IHsFND.Np.LSEIVIREQQYGSKTQAMLYFCFSI...L...ELKT...A...TP...........LLNRTAsLKEHALLhIHKTNA.hFLEMLKIFGLLSQAHHNDVLKILEKILpN....	0	1	2	2
+9355	PF09523	DUF2390	CHP02444; 	Protein of unknown function (DUF2390)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are bacterial hypothetical proteins, about 160 amino acids in length, found in various proteobacteria, including members of the genera Pseudomonas and Vibrio. The C-terminal region is poorly conserved and is not included in the model.	25.00	25.00	26.30	27.90	22.50	19.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.40	0.72	-3.88	60	298	2009-01-15 18:05:59	2007-05-04 09:10:55	5	1	295	0	89	240	56	106.10	35	65.72	CHANGED	psLWpauLshYupsuVppuCLpLQsphGssVsLLLhshWLs.....p..pshshsspphptltstsppWcpplltPlRplR+ph+stssps..........lhcplhshELpuE+hp.phLh	..p.pLWpFuLphYut.tVcpA.CLp.LQspptuNVNLLLhhtWLs.....p.ptl.shsppchtpltpslsphp-sllpshRcLR+phKsphscs..............LhcchhphELphE+ppttpL.h...........................	0	21	44	68
+9356	PF09524	Phg_2220_C		Conserved phage C-terminus (Phg_2220_C)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents the conserved C-terminal domain of a family of proteins found exclusively in bacteriophage and in bacterial prophage regions. The functions of this domain and the proteins containing it are unknown.	21.10	21.10	21.20	25.60	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.64	0.72	-3.98	26	362	2009-01-15 18:05:59	2007-05-04 09:12:02	5	7	326	0	39	286	12	73.70	47	26.64	CHANGED	IIsYLNpKuG+sF+.ssptspcLI+ARhpEGasl-DFKpVIDhKspcWhsssp.....hppYLRPcTLFu.s.KF-uYLNp	...................................IIcYLNcKsG+pa+h..s..otpopchI+ARhs-.GaplE........DFKpVIDhKss-Whsss.......hscYLRP-TLFG..sKFEuYLNp........	1	16	26	37
+9358	PF09526	DUF2387	CHP02443; 	Probable metal-binding protein (DUF2387)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.	24.40	24.40	24.50	25.00	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.96	0.72	-4.06	44	844	2012-10-03 10:42:43	2007-05-04 09:13:20	5	3	840	0	112	300	136	62.10	57	89.83	CHANGED	hKKRFIAGAsCPpCsphD...plthap-ss..l-hhECVpCGas-ppssp......tsphpsR...............sptpsIsl..F	....RKRFIAGApCPuCpAQD...ohAMWRENN....l-lVECVKCGHp.RcsDK......pscc+VR...............pcEQVIGIF.......................	0	18	40	78
+9359	PF09527	ATPase_gene1		Putative F0F1-ATPase subunit (ATPase_gene1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme.	23.00	23.00	23.20	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.74	0.72	-4.16	277	1319	2009-11-03 13:52:42	2007-05-04 12:08:56	5	2	1253	0	429	996	1353	54.40	25	56.48	CHANGED	uhhht.l..Ghplls.sll..lGs..hl.GhhLDphh...so.t..shhhllhlll.GlsuGhhshh+hhp	.............h..hhtl..uhphls.ull.lGs.hlGhhLDchh.......ss....Phhhl.....lhlllGlsuGhhslh+hh...........	0	172	321	377
+9360	PF09528	Ehrlichia_rpt		Ehrlichia tandem repeat (Ehrlichia_rpt)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Repeat	This entry represents 77 residues of an 80 amino acid (240 nucleotide) tandem repeat, found in a variable number of copies in an immunodominant outer membrane protein of Ehrlichia chaffeensis, a tick-borne obligate intracellular pathogen.	20.50	20.50	21.20	20.90	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	688	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.09	0.70	-13.79	0.70	-6.39	2	47	2009-01-15 18:05:59	2007-05-04 12:09:46	5	4	7	0	6	47	2	244.40	44	123.71	CHANGED	MDIDNsNloTushpspossLh-lIMRILsFGNps..psps.soclh.pp.p...sDsVupPS................LpPhVstS..........cVScsppEcosPEVhhcDLQ.....sltpppStVu-psupsspEcps.Elcucphpsth-sulpcSppc.sEhVSpoSpE..ssE......................pcVSKsppEEosPEVhhcDLQ.....sVtpppStVu-psupsspEcp.....................SEltp+.ucTpKEpuhsEs+tc-.....D-.VppsSSE...stpcVScsppEEssPEVhhcDLQsssstp..........VpcppSEltp+.uETpKEpuhsEs+tc-.p.sspsS.E..suE..pcVScsppEEosPEVhhcDLQ.....sVtpppStVu-psupsspEcpo.Elcucphpsth-uulpcSppc.sEhVSpsSpE..ssE......................pcVScsppEcosPElhsEDL.......ltps.s.VsEK.sEh.t.p.sP.VhtE-.................-KVsETscpE...Elht-sQsVtsupsl.lsPM.sl-shDo.l...........SslhpstMhCPhSc..sGpaVphYthYhYthQsVKDL.Gsh..shssC.CNlslYFhtaN.FTN+Esl......Dll	.......................................................................................................................................................................................................................................................................................................................................................................................sptp..........VpcppsEltp+.uETpKEpuhsEs+tc-.p.VspsSsE.alAE..pcVSKl-pEEosPEVll+DLQ.....cVspp-SsVuDpsupsssERpo.Elcucphpsth-uulpcSppc.sEhVSpsSpE..ssE............................................................................................................................................................................................................................................................................................	0	4	5	5
+9361	PF09529	Intg_mem_TP0381	intg_mem_TP0381; 	Integral membrane protein (intg_mem_TP0381)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of hydrophobic proteins with seven predicted transmembrane alpha helices. Members are found in Bacillus subtilis (ywaF), TP0381 from Treponema pallidum (TP0381), Streptococcus pyogenes, Rhodococcus erythropolis, etc.	21.80	21.80	22.20	22.30	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.70	0.70	-5.11	43	802	2009-01-15 18:05:59	2007-05-04 12:30:38	5	1	697	0	95	583	737	219.40	29	92.57	CHANGED	hhsFphaussHhshlhhhllhslhlhhhhp................phptpppphhpphhshlhhlphluhhhah..hhhshhsltpsLPLahCcluhhhhslhLlscp..phhhphhaahGlsGuhhALlsP-l..........................................sasFPHhpahsFalsHhhllhsslahlhhpph+sshpshhtsllhshhhshhlhhlNhlh..........GuNYhaLsppP.hssohLslh...ssaP...hYllsthslshhl...hhlhh............................hsat..hpc	................h..shphhpss+hslhhhhhlh.sllhlhhhp................thp.h.p.p.p..p.h.hphhh...thl.hs..phlhL..a..sWa....hs...s..............th..s....L.s.p.SLPhahC+lAhh..s.lh...lls..p....p......p+.ht.p.......h....hh.h...h...GhhGulhA...llhPs.h.........................................ssY.sF.P.HlshlsFhhuHhsLlhsuLhhlh...c..p..Y.c.sph.hshpthhlhshslssll.hhVNhlT................GGNYuF..LscsP....ssp..h..Lsh.......................Yllsshllshhl.....hhhh....................................ph..................................................	0	32	65	82
+9363	PF09531	Ndc1_Nup		Nucleoporin protein Ndc1-Nup	Wood V, Coggill P	anon	Wood, V	Family	Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.	19.90	19.90	21.20	20.20	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	602	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.89	0.70	-6.10	34	331	2009-01-15 18:05:59	2007-05-04 13:22:05	5	8	241	0	220	326	0	466.90	18	88.01	CHANGED	ppllppRhst.ustlslhlshlhhhshhl..........thhohhhshhsh...hh+slhlhluslllhlhRhp.hpl.t.psp..sohhsplhptlhshphl.hhlhashuuh.hhuhhath.hstsh..t..hh.................t.tppshLN-phlalhhhthhluhhh...........oltalhhshsclsF..............s....hpp..tppltppl.phlhpu..lhpohhshhstsllY..................hh..hh.hshh.h.thhhshsps.h.sshh...hshpllhphhlhuhhllhsW..phsNhhFslahops.slctspsloshop-Ppt..oLlsGLp.spc....hs+hhAhpELshluppsssc....Rpslasspptss..ssWstlhcpChplIpphssclsphhpt.t.....ststhss..ppppspp...........................................................t.......t...h....st...pt..h.t......hptshsppshpssssssthst.tp..pttpplhsthpphhp...............................................................hpphLpphhsh.athohp+pspshl......ss.hhspAl.uLotLlhtSlpEDpaGsVpss.lspllphlpchhtslspahph.sssshhst..............tttpp......stlphlhsshpsulhcIshpFstaLp-lhLsscsh+hhp	.......................................................................................................................Rh......hh.hhh....h....h.h...............................h.....h..h.h.h.hs.h..hh..hh.ht.hh....h............s...ht...h...h...ph.h.h.hha...h.uh..hhs..hh...h...h..........t............................................hst...lahh...hhhuh.............sh.hhh.p..hthl.h.....................sh.....t.....h.hhtt.l..hh..hpu..hh.shh.hh.h..hha...................h.....h.....h.thhhs..hp.........s.....h....sh.......hh.hphhhhuhh.lhhha..ths...hhapha.hspt.sh.....t....ss..hsps.spt......sLhpsLp..sp............................hhphhA.h.-Lhhlupt..ssp.....RttlFp..p...t.......s..s..tsWstl.ptChphlpthspcl.th.p..........s......t....t....................................................................................................................................................................................s.......................t..t.h.h...tp........................................................................htthh..p........h.ah.sh..php..h.......sp...hh.uhp.uL.stLhhtShpEDpaGhVpps...lstllphhhph.tslcph.....h........t................................................................t.........t.h..hhhtshppulhplh.tFt.hlptl.hs.p..p.................................................................................................	0	65	111	182
+9364	PF09532	FDF	DFDF;	FDF domain	Anantharaman V	anon	Anantharaman V	Domain	The FDF domain, so called because of the conserved FDF at its  N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [1]. It is found at the C terminus of Scd6p-like SM domains [1][2]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain [1].	26.10	26.10	26.20	26.20	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.56	0.72	-3.49	18	611	2009-01-15 18:05:59	2007-05-04 13:55:02	5	11	255	10	383	561	2	97.50	26	19.68	CHANGED	hc.cpDFDFEusNuKFsKpclhcchcpptphtttt.....................ppppssspcpspsssphhs+ppsFFDsISscspccsttss.t..................................apcEcchs..ETFGhst	..........................................ppDFDFEusNApF.sKpc...l..h.......cch.p.pp.p.h......t...t.p.pt..tt..t.........................ptpptt.pp.c.s...h.s.ss......t.h...hs+ppsFFD.s.l.Sscs.p...p..pp...p..s...............................................atppc.phs..-TFG..................................................................................	0	78	159	280
+9365	PF09533	DUF2380	CHP02269_MYXXA; 	Predicted lipoprotein of unknown function (DUF2380)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of at least 9 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. One appears truncated toward the N-terminus; the others are predicted lipoproteins. The function is unknown.	25.00	25.00	25.70	25.60	23.40	23.40	hmmbuild  --amino -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.40	0.71	-4.88	8	28	2009-01-15 18:05:59	2007-05-04 14:10:00	5	2	8	0	27	29	0	164.80	35	60.96	CHANGED	uhpsApEtCsssDEspCVSLLCpGDA.CGFYcCEDlsGcVEh.ARFPPA.....RPPsAsAAPGpGPRRsWGsGQpLPRGA..VMVFPsWsGAPpchlsPuhpLsPG.RWEKHHIFPQAcDLAcWFpp..+GVKIHDYThPIPR-lHRRIHuGsspGGAWNcAWR-F+cpp.G.A.SP-EIa+HAGELIaRFELhGGPIpPY......YSR	...........................................t...t.t..Cttspts.ClshhC.tsh.CuhahCEDlss...ts.h..uth.ss.......RPPh.......G.sspRsW.Gtt.tl.tss..lhsF..W..t.t..h.sshphssG.ca.....cKHHIFPQt.cLApWFpp..pG....lcIHcaTlsIPcclHpRIHuGs............s..p..GGs..WNpsWRpFhpts.t..A.o.pplac+AucLIhRFpLh.G.l.sYa.................................	0	11	13	21
+9366	PF09534	Trp_oprn_chp		Tryptophan-associated transmembrane protein (Trp_oprn_chp)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	24.90	24.90	25.00	25.10	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.36	0.71	-4.68	24	358	2009-01-15 18:05:59	2007-05-04 14:15:32	5	2	348	0	99	256	3	178.30	31	85.29	CHANGED	tIA.tLlLlluAusLWhAuRhsWVslpSFDsLGs........P+sssLoGAoWooALlPLALLhLAAsVAslAVRGWsLRlLAlLlAsAususuYluloL.WV....ss-sAsRuusL..ApVPlss..lsGopRphhu...........AslullAushsLluAVLLhppAs.ptsAts..uRYssPsARRutApppts.....t............hSERhlWDALDEG+DPT	...........................h....hhhhhuAhhh.hhu.up.sW..h.h.s..s..hs..........shthsloGushosu.L.h.ulALlhlAu.ssAs.hs.V.RshuRRllulLhAlsuhuhshhslsh...hh...ts.s.s.Atpsush................sts.s.sst......hsss.pho.sWs............hlslluuslsl.luulhLhhtus.chsutu......s+Ytt.tARRstthpt...............................................................s.Rsl..WDALDcGcDPT.....................	0	30	74	94
+9367	PF09535	Gmx_para_CXXCG		Protein of unknown function (Gmx_para_CXXCG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry consists of at least 10 paralogous proteins from Myxococcus xanthus and that lack detectable sequence similarity to any other protein family. An imperfectly conserved CXXCG motif, a probable binding site, appears twice in the multiple sequence alignment.	25.00	25.00	29.00	28.40	20.70	18.80	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.59	0.70	-5.36	11	36	2009-01-15 18:05:59	2007-05-04 14:22:52	5	2	9	0	31	35	0	184.80	40	91.83	CHANGED	RFahl+cDcssp..aTGsL.sAsH+WuLPGVpsCssCGsshGssGhpYPCVDLSsLP..EppchscP.hPlsaEEFuRLRELVRPhAPPGAhL.PGTphGPLsGsASGpFGsLhhQsshsLhlRREALERLputGlRGLpGCsh-lRFRtKsPPELLELQLE.+GRLHPDClPsDctPPCssCGsp.shphP.-sslLDAsSLPsslDlFRltsasTlIluTERFVEAVc+LcL-GlsFpELssR	...............................p.s.s.....hsGth.pu...WthPGlt.Cs.st.shu..h.tYPsVDLuths..t.t.h.ps...h..shpEatRLtp.lRPhhP.th.l.PGsthGPhhGtupGtFu.h.h.ss..lhlRp-Ahc.Lpt.GlpGL.us.hpl+hRtptsPtlhcLplp.pGplH.cChssth.ssCspCGp..sh........phP........ct.hL-stSLPsshDlFRltsasThlluTERFV-Alc+LtLsGlsFpElss+...	0	12	12	23
+9368	PF09536	DUF2378	Mxa_TIGR02265; 	Protein of unknown function (DUF2378)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.	21.20	21.20	23.10	22.50	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.81	0.71	-4.75	27	82	2009-09-10 15:59:30	2007-05-04 14:23:17	5	1	10	\N	69	82	2	174.80	24	87.95	CHANGED	thhs.sp...sscGLFhpulhstlp....tthtpcl+psuh....-hcts.h.sYPltsahphlhsAAptltPph..s.-sAhRtlGcphspuFh.pohlGRslhslhthhuP+Rhlsplspua+.uussYsEpplp.h...Gspssclhhpcsh..sssappGlLpusLcssGAps.pVpspthsh.hsssYclsWp	........................................hh.tpshcGLahpulhshlp........tthtpclctsGh...-hct..h.sYPhptahphhtssAchlhPth..sh-tAhctlGcphspuah.pohhG+slhslhp.hhuP+RhLpchspuap.sussasctplpth...Gspssclthp...........cshh..sss....att....GllpusLchsGupsspV...p...spthss.t.sspYclpWp.......................	1	20	20	50
+9369	PF09537	DUF2383	CHP2284; 	Domain of unknown function (DUF2383)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	Members of this protein family are found mostly in the Proteobacteria, although one member is found in the the marine planctomycete Pirellula sp. strain 1. The function is unknown.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.89	0.72	-3.82	79	432	2012-10-01 21:25:29	2007-05-04 14:23:56	5	2	358	2	189	457	26	109.50	24	67.21	CHANGED	pslss..LscLlcsshDuppGacpuu-clc..s.spL+shhpchupp+pptspELpstlpphG..scPcss.uShsGslHRsahsl+utlousc-p.slLpcsEcGEctslcpYccALc.c	...............hhptLNcLlctspDutcuacput-csc...s...spL...+........shhpchsppppptspcLpshlp.phG...ucPpps...uohtGslp+sahsl+s....hhss..p.c.cp...lLppscc.uEctshctaccslp.......................................................	0	49	115	153
+9370	PF09538	FYDLN_acid		Protein of unknown function (FYDLN_acid)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are bacterial proteins with a conserved motif [KR]FYDLN, sometimes flanked by a pair of CXXC motifs, followed by a long region of low complexity sequence in which roughly half the residues are Asp and Glu, including multiple runs of five or more acidic residues. The function of members of this family is unknown.	23.80	23.80	23.80	23.90	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.31	0.72	-11.07	0.72	-3.47	63	299	2009-01-15 18:05:59	2007-05-04 14:25:01	5	1	295	0	110	234	357	112.80	36	90.88	CHANGED	MsKtEhGTKRlCPssGp+FYDLN+.sPllsPhsGpshshc................ss+s+thtspt-c...................scpscsssss-.ssl--s-s-.p..................p-s..t..--....DL-s.-DDs.......hcD-D-	........MAKsELGTKRlC..PpsGcKFYDLN+.cP.ll.sPasGpshshs................hhcspt..tsst-cst................tpchcss..pps.-hssl--.s.Ds.-sph...................................sDDl.s..D.sDD...sl-ls-...DDDs......hhtp-----p...................................	0	33	70	85
+9371	PF09539	DUF2385	CHP02301; 	Protein of unknown function (DUF2385)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this uncharacterised protein family are found in a number of alphaproteobacteria, including root nodule bacteria, Brucella suis, Caulobacter crescentus, and Rhodopseudomonas palustris. Conserved residues include two well-separated cysteines, suggesting a disulfide bond. The function is unknown.	25.00	25.00	58.40	58.10	18.80	17.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.20	0.72	-3.61	16	161	2009-01-15 18:05:59	2007-05-04 14:25:50	5	1	159	0	59	119	6	95.00	52	72.36	CHANGED	PY-tpLhRLAEILGulHaLRsLCu.tscsspWRscMptLL-uEsss-.pRRpRLhuuFN+GYRuFussYppCTsuAphAhpRYhpEGpsLoc-IsuRY	.......PY-schhRLAElLGoLHYLRsLCG..pcGscWRccMpAlIsAEpPs-.tcRt+LluuFN+GYRsFussYspCTPuAhsAlcRYhcEGucLSp-IhuRY....	0	15	31	40
+9375	PF09543	DUF2379	CHP02267_MYXXA; 	Protein of unknown function (DUF2379)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of at least 7 paralogs in Myxococcus xanthus and 6 in Stigmatella aurantiaca, both members of the Deltaproteobacteria. The function is unknown.	20.00	20.00	20.20	20.00	19.70	18.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.41	0.71	-4.16	16	44	2009-01-15 18:05:59	2007-05-04 15:28:38	5	2	5	0	43	43	1	103.10	42	91.86	CHANGED	scphDWsPIRuLu+RVlcpGEPLtLTc-VRALLpRoAcEVuIosu-sppALuosssAtsLLcEhpRRI+-GSpRLhcAlpRhhchp-AGDlDuARppMc-VLAVEVVPhYRchApspLcsls	......s...-Wp.lttLs+RV..ptGtsL.LotchRuLLh+oAtEVulstt-sttALto.tsAhsLLpEhtcRIp-GSpRL.cAlhc.hhchp-uGDh-uARpphc-lLAVEVVPhYRchAptpLcsh.......	1	9	9	30
+9376	PF09544	DUF2381	Mxa_TIGR02268; 	Protein of unknown function (DUF2381)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of at least 8 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. The function is unknown.	20.60	20.60	20.60	20.80	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.67	0.70	-5.30	21	91	2009-09-11 05:39:59	2007-05-04 15:29:54	5	3	9	0	71	90	0	237.80	24	91.05	CHANGED	sLLhussApApss..sspt.ptRsVslsusssp..ssPEV+VussssTsL.lFsuslpccslsl-..cuRhphlDsG..cpolhLtPsssLttGERhcLsVhFtDGssPspAsFlLVsc.Puc.......sDspl-VpRsttsstuhpsE..s........t...t..phcsptstPpshsL.Ghlsp......pGVssp..plpc..hsssupultstsuh..sYRu.tshshVslplcN.suttPWssp..tApLs.....uts.G.sL+shhV.hppuslsPGpt.scVlV.s-ssshusp....ssFT...LcLhspsG.RslplssVph	...................................t..ss.ut...........Rtl.lssp.st..s...lhlusshsThl.hFssslt.tphph-..csRhphlssu..tptlhltshtslt.sE+h.ltVhatDG..t.P.pssFhLssp.ssc.......s-t.lpV.R.ttsstsh.sc..h...................t.pt..ttststshs...h.uhlsp.......pultht....hpt....htssspshthhthh..sapu.tshshl.hplpN.tsttsWtst..tAplp..............stt.G........hcshhl.h.........ptsslh.PGtt..splhl.s-.hss.htst....t.as...Lclht.tsG.Rsl.l.th.................	1	13	13	56
+9377	PF09545	RE_AccI		AccI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the AccI (recognises and cleaves GT^MKAC) restriction endonuclease.	21.00	21.00	24.60	24.40	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.09	0.70	-5.91	2	13	2009-01-15 18:05:59	2007-05-04 15:31:22	5	2	8	0	7	20	3	229.80	29	92.59	CHANGED	MsYY-pIREhTK.VPVpLVsFEpPRDhARTPTQASSNFITNKEQGDWAEsLlsRAINEsSpNFVAVKYGKSDNLVAGEsGFDsFYQDFQsELDTIGKRPDLLIFpKsDFDsoLGFDlSQ.PHcpITDYVKKAIAGIEVRSSAFLID+YEEAMQsRTp+FspIAhpT+DKILs-F.DVL-HPuRppYIpLLNolThpTlslhDF+VPuWpSs-RLIpVpNLFKpLKsAIKEIQKRDYLSITPKVEDlKVVYKWIETFNVPHFYFQVFFDKVYGISFEQILpIISsSDNDGVIFSVEpDspNQNKTTIKINSKhGhPIA.KVDEPhHESlRKEMDRGRLLFYVTFKGGTAYLDl-NLRsILslEEu.F	........................h..................................sSpFlhphpQGsWuEphlhpAIN-ss.pahAltYG.Stshsss-.puFt.aatchppth.shsKRPDlLlFp.ss...h.p.....................pl..........hV.cAlhulEscsS.ahht+h............................................................................................h.K.EDht.l.cW.pp.sV.hahhpVFFDhhaslSFpph.pll.....p...........u..h.h-p..ps.....p.Khhhhh..p.uh.lh.h.-....P...shh.E........ppG+ll.hVpF.GG.hhl........................................................	0	3	4	7
+9378	PF09546	Spore_III_AE	spore_III_AE; 	Stage III sporulation protein AE (spore_III_AE)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This represents the stage III sporulation protein AE, which is encoded in a spore formation operon spoIIIAABCDEFGH under the control of sigma G. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.	20.40	20.40	20.70	20.70	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.98	0.70	-5.48	32	401	2009-01-15 18:05:59	2007-05-04 15:34:36	5	1	393	0	90	304	11	320.30	36	82.95	CHANGED	lP..phshpphl.shh+.G-t..shshpchhpullpalF+Elhssh+LLupLllLullsulLpNLQsAFp.ppsloplAahlsYhlLlhlslpSFtlAlshuc-sIssMssFM.uLlPlLlsLlsusGulsouAhFcPlllhslshsuplhpslllPLlhluslLpllsslS-ca+lo+LusLl+phuhhslGlhlTlFlGllolpGlsuussDuVsh+TAKFssssFlPVVG+hhoDAs-sVhGsSLLlKNAlGhhGlllllhIshhPlIKllulshlYKluAAllpPlu-pclsssLsshusolhhlhuslusVulMFFlsIsllluuGNls	...........................................................p.phtshh.phlp.Gct..phoh.pphhtulhpalF+ElhsstKLLupllhLslhuulLpsLQsAFp.ppslSc...lAa.hlsYhlLlhlslsSFhlshshAp-sIpsMssFhhuLlPlL.lsLlAouGGlsSuuhaaPlllhhhshsuhlhptlllPLlhluslLplVssl.S.cpaKlo+LucLLpplshhhlGlhlTlFlGllolQGhss.ussDulsl+TAKFssusFIPVVG+hho-As-TVluuSlLlKNslGllGlllllhIshhPhIKlhsluhlYKhuAAllpPlu..s.stll.pCLsslucSlhhlhuslshV..ulMFFloIsllluuGNl....................................................................	0	47	75	80
+9379	PF09547	Spore_IV_A	spore_IV_A; 	Stage IV sporulation protein A (spore_IV_A)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	SpoIVA is designated stage IV sporulation protein A. It acts in the mother cell compartment and plays a role in spore coat morphogenesis. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.	25.00	25.00	30.50	30.50	23.00	22.30	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.65	0.70	-5.80	30	421	2012-10-05 12:31:09	2007-05-04 15:44:18	5	2	408	0	87	296	12	475.10	56	99.67	CHANGED	MEphsIY+DIAcRTsGDIYlGVVGPVRTGKSTFIKRFMElhVlPNIcstac+-RA+DELPQSuoG+TIMTTEPKFVPNEAVEIsl.s-slch+VRlVDCVGYhVcGAlGa..E--p..PRMVpTPWF-cpIPFpEAAEIGT+KVIs-HSTIGlVVTTDGSITDIsREsYl-AEERVlpELKpIsKPFlllLNSpcPtupEThpLpp-LE-KYsVPVlslsstphpccDIppIhcplLaEFPVpElNIslPcWlEpL-ssHWLKpshhssl+-hspslp+lRDIppslpsls-hEalccsplpplshGsGsApIplssccsLFYclLsEhoGhcIcG-pcLlpllc-LupAKcEYDKltsALp-VKpsGYGlVsPpL-EhpLEEPEllKQGs+aGVKLKAoAPSlHhIRADIpTEloPIlGTEKQuEELVpYLLccFEs-PpcIWpSNlFGKSLc-LV+EGlQNKLa+MPE-uQsKLQ-TLQKIlNEGsGGLICIIl	.....MEphcIaKDIAERTsGDIYlGVVGsVRTGKSTFIK+FMELlVlPNI-.N-tc+pRApDELPQSAuG+TIMTTEPKFVPNpAVpIpl......s-ulclplRLVDCVGYhV.GAtGYt..--ssPRMlpTPWa-c.IPFpEAAEIGTRKVIp-HSTIGlVlTTDGoIs-IPRcsYlEAEERVlpELKpluKPFllllNospPhps-..TppL+ppLpEKY-lPVlshsltphcEpDlhslLccsLaEFP........VtElNlslPpWV.hLspsHWL+psa.psV+-slcclp+lRDl.ccs.ltp.hsph..EalccsplstlchGpGsAcIclhs.-pLa.pILpElsGhEIcGcscLlplhp-Lu+AKpEYDpVu-ALc.VKpTGYGlsuPsLs-MsL-EPEII+QGuRFGVKLKAsAPSIHMI+sDlEoEhsPIlGTEKQSEELV+YLhp-FEsDP.pIWpSsIFG+SLpslV+EGlQsKLthMPEsuphKLp-TLp+IINEGsGGLIsIIL..................................	0	46	72	77
+9380	PF09548	Spore_III_AB	spore_III_AB; 	Stage III sporulation protein AB (spore_III_AB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	SpoIIIAB represents the stage III sporulation protein AB, which is encoded in a spore formation operon: spoIIIAABCDEFGH that is under sigma G regulation [1]. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.	24.90	24.90	25.60	27.90	23.30	24.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.72	0.71	-4.51	37	385	2009-01-15 18:05:59	2007-05-04 15:44:36	5	2	379	0	87	291	10	165.10	33	98.57	CHANGED	KllGulLIlhuoohlGahhupcapcRscpL+pLpsuLphLcsEIhYutTPLs-AhppluppsptslutlFpphuppLppppstostpAWpculpphh.ppssLppp-h-lLhphGpsLGppDhpsQpKplpLshppLcpp.pcAcpttp+ptKha+.LGhlsGlhllIlLh	.......KlhGslLllhuoohhGa..thApphpcRscpL+pLptuLptLcsEIhYupTPLsEAhpcluc.p.......h.s.p.PlshlFpphuppLppsc..p..osp-AWpcul...cc.h...pp...suLp.pp-hElLpphGcsLGppDp-sQpKplcLslppLcppppcAcptptchpKMh+sLGlLuGlhlVILLl...	0	45	72	77
+9381	PF09549	RE_Bpu10I		Bpu10I restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the Bpu10I (recognises and cleaves CCTNAGC (-5/-2)) restriction endonucleases.	25.00	25.00	56.80	56.60	17.90	17.70	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.18	0.71	-4.75	8	25	2012-10-11 20:44:45	2007-05-04 15:49:05	5	1	23	0	6	28	5	190.50	33	72.57	CHANGED	QpcLcsSILEEFh.hLhpphhtt....hssplclG......ppsFsslsFh.sohtshhpuscstl+sKDpDFsIG.ptl.lKlohcschspspps.-hslshVAsECKTNLDKsMLp-ssuTAccLKpssPsuLYallsEaLDhs.ssss.ssTpIDEVaILRKp+Rsssphh...............hhchlshsPlss-VhhcLlccVpphLscsu.cssp...sLpRGal	.......Q.cLcsolLEEFh.hLhp.ch.l.t....hssshp..lG......ppsFtsl.Fp.oshtshhpss.shI+pKDpDFslu.pph.h+hohpsp.ssh.pp..phplshlAsECKTNLDKTMhQ-susoApclKtssPsuhYhllsEaLDhT.Phss.phTplD-VhlLRKsKRhssphR...............ahchhsppPlts-lht+llpclpphlssst.ssps...sLpcGah..	0	2	6	6
+9382	PF09550	DUF2376	CHP2216_phage; 	Conserved hypothetical phage protein (DUF2376)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a family of proteins found exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.29	0.72	-3.81	39	165	2009-01-15 18:05:59	2007-05-04 15:50:55	5	2	163	0	50	131	32	41.30	41	61.95	CHANGED	LtLpPcpFWsLTPsEL.phh...lGhpu.u.s.uPlsRutL-pLhppaPD	.Lth.PttFWthTP+EL.s...hh.........lGhtu..s.s..sshsRspLDuLhttaPD.......................	0	12	27	37
+9383	PF09551	Spore_II_R	spore_II_R; 	Stage II sporulation protein R (spore_II_R)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	SpoIIR is designated stage II sporulation protein R. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species. SpoIIR is a signalling protein that links the activation of sigma E to the transcriptional activity of sigma F during sporulation.	25.00	25.00	25.90	25.80	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.67	0.71	-4.12	40	391	2009-01-15 18:05:59	2007-05-04 15:52:32	5	3	385	0	90	332	8	130.70	44	55.25	CHANGED	lscclIRhHVLANSDSspDQpLKh+VRDpVlchlpstlp..sspsh-Eu+plIpspls-IcclAcphlpcpGhsYsVpsphup.hsFPsKtYGslshPAGpY-Al+IhIGcGcGpNWWCVLFPPLCFlDhoputs	..................lsccslRh+lLANSDSccDQsLKh+VRDtVhttlsshl...s.......sh...p....S.h-Eu+cllpscls-IcchuppslccpGh.s..ssplphuc.spFPTKsY..........G........shlaPAGcYEAlhIsIGcG..cGpNWWCVLFPPLCFlDhopu.s...............	0	47	75	80
+9384	PF09552	RE_BstXI		BstXI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the BstXI (recognises and cleaves CCANNNNN^NTGG) restriction endonuclease.	25.00	25.00	114.10	98.80	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.85	0.70	-5.37	3	10	2009-01-15 18:05:59	2007-05-04 15:59:13	5	1	10	0	2	10	4	279.30	35	80.40	CHANGED	RKIYKTGQT..RGADcssIYQNRVSRNSTVLIPFEhl.pcspEsVstucY-NGYIVLIsPDaYF-cA+s-Kspshp.sstlsLGVNAllaYpQRuQa-cYsP.LsDhpspGL+pTpPhs..RouDl..GGcYVuRlSGTTuE..KcuKIphGaN.Tsu+GAGIRlaEYAssET..LEKARLQLEuhYWLsc-SL-uAIpaGMSscDAccR+c.oaNEAcpQGL........LppIcLlssRIIDccslTlCPLCLp+I............SASGFas+sEQsEhRcsaDLToTEINLFHIsELRYGALpHKPYNLGWGHH	.....................pKl.KTG.T..RGAspstIYQNRVsRNssVLIPachh...sp...tssst.sp.Y-sGaIVLlsPc.YFssstss+hhhhp....tlpLGlNAllaYppRspWssasP..ssh.tspGLshsssps...Rpssl..uGpYVARIsuTT..uc............ctc+I.hGas.....t...p...sh+GAGIRlaEYAopEs..Ip+sRLQLEAhaWLscDSlEshhthGMs.pDshpR+c.sLscs.pcpGL..............................L-hpcLh-hRIls.ccshTICPLCLccI............SApsFas+hEQsEGRcsaDLTsTElNLFHIcELRaGphsHKPYNLGWGHH.	0	0	1	2
+9385	PF09553	RE_Eco47II		Eco47II restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the Eco47II (which recognises GGNCC, but the cleavage site unknown) restriction endonuclease.	25.00	25.00	27.00	27.00	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.28	0.70	-5.21	6	64	2012-10-11 20:44:45	2007-05-04 16:05:53	5	2	59	0	13	61	7	190.80	44	79.26	CHANGED	LoFIS-EDF.NcVpsTIscYpcpLcuh-hK+FsKNlIDPhKhIFDtslap.SacEhlssElhRQp-Ko.sNcIGhFHQ+IhtaIcsh+s.Ps....GaDV.htNs-..........pplasEhKNKHNThsuussuchahKhps.lhsctpp.cDssCahVElIs++SpNhpW.hpsssp+.........upcpIRhlShDpFYpLVTGppDAFpplshsLPhsI-KhlsE	..........................................LsFIoccDh.pcVptTl.pp.Ytct.Lpuh-lK+FN+NlIDPIKLlFDpslaptoaEcllpsElhRQpDKoNsNsIGYFHQpIFpYl.cs.hcVPps....GaD..V.hps.sp............pplalEhKNKHNTMNSuSuupsahKhQsplLpc....ccssCaLVEsIAK+SQNlpW.hplcspch........upphIRRlShDpFYtlVTGpcDAFhphChsLPpllpchlp....................	0	7	9	12
+9386	PF09554	RE_HaeII		HaeII restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the HaeII (recognises and cleaves RGCGC^Y) restriction endonuclease.	25.00	25.00	106.70	106.50	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.11	0.70	-5.44	4	29	2012-10-11 20:44:45	2007-05-04 16:07:30	5	2	29	0	2	17	2	315.50	69	92.61	CHANGED	AK-ALDsIIKKuRVHLYKPIQIAEILYpcRs.csL..sL.NL-TYRspSK+WRDlIChRFLGRlSTSSAKaQDNLFEcNAhPPchLslLGp.N+pssGhVEuYIY+pFh-RasQMosuLsYshsosh-NF+LoEFLs.FW.EPGLKRSIDKIYEIVVYALFcsLlppLsVpVcIphshsNlDLLcEFpDFocKllolsupNsphpLsAKhaRVGVTNAADRGLDMWANFG.AlQIKHLSLsE-LAEsIVSSloADRIVIVCKcuEEclIlSLLNQIGW+SRIQSIITps-LIsWY-KALRGpas.llGp+llEplppEIphEFPus.-sNDF.sFhcpRtY	.....AKEALDsIIKKSRVHLYKPIQIAEILYHDRshKpL..-hLNL-TYRNpSK+WRDpICpRFLGRlSTSSAKFQDNLFEcNAhPPE+LuVLGshNRposGGVESYIYKpFFsRFSQMSpALAY..VG..soD+.SFQLSEFLNLFWLEPGLKRSIDKIYEIVVYALF-uLVoELGlTVoIDaPcENLhLhcEapDFu-KIIoh.PcNp+LcLsAKIHRVGVTNAADRGLDMWSNFGhAIQVKHLSLDEELAEsIVSSISADRIVIVCKcAEpSVIVSLLTQIGWKSRIQNIVTEDDLIsWYEKALRGpYs..IAEsLLEsI+sEIhcEFPAV.EANEFl-FtQsRGY......................	1	0	1	1
+9388	PF09556	RE_HaeIII		HaeIII restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the HaeIII (recognises and cleaves GG^CC) restriction endonuclease.	25.00	25.00	25.40	25.30	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.89	0.70	-5.54	4	54	2009-01-15 18:05:59	2007-05-04 16:09:16	5	3	51	0	12	46	1	272.30	48	88.81	CHANGED	G+AaEYAhlpuLtptLsssQcVlIEpNSuhplshcpYcshocphpp+hshuAcAulplILcLEP.Los.lsNss..LhLuIQcDs+Gp.GDVRDILhhRcp.pWEIGLShKHNHsAVKHSRLSRsIDFGEpWFGlPsSQsYaDpIpPLF-cLEphKccG.LWRslsNKE-cIYsPLLcAFIpElc+lspNppulIPpRhlpYLLGp.DFYKlIohDp++lTplQAFNhhGTLNRsSs+c+Phl.lP.h.hPTRhhcIsFKPsS+NTlElhLDpGWohSLRIHNASocVEPSLKFDl+LlGVP	......GRAYEaAhh.sL.pplsh..h.c.pl.ltcpsua.ss.cAapsLpcphpphahtSAhtul.hlhchEPhlp-..sssp..lpLplQpDphGchGDlRDILIhh...c...p..WpIGLSlKHNH.AVKHSRLS+cLDFGc+WhGlssSQsYaDsIcPlFppL-stKccs......hhW+-lsN....KEp-lYhPLLpAFhcElhRhtpp...pps.......lPp+hVEYLLGcaDFYKsI.l-pcphTplpuaNhpsTLN+.ShcpKsphhl.PlspLPTRhlthcFK.....P..........p.....StNTlElhLDpGWpFShRIHNASo+VEPSLKFDIplluhP.......	0	5	7	9
+9389	PF09557	DUF2382	CHP2271_C; 	Domain of unknown function (DUF2382)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry describes an uncharacterized domain, sometimes found in association with a PRC-barrel domain Pfam:PF05239 which is also found in rRNA processing protein RimM and in a photosynthetic reaction centre complex protein). This domain is found in proteins from Bacillus subtilis, Deinococcus radiodurans, Nostoc sp. PCC 7120, Myxococcus xanthus, and several other species. The function is not known.	18.60	18.60	18.90	18.80	17.90	17.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.59	0.71	-4.17	46	499	2009-01-15 18:05:59	2007-05-04 16:29:31	5	9	317	0	179	399	8	106.10	31	43.13	CHANGED	lpLhEE+LpVsKc+hpsGcVclpKcVhp-ppslsVPVc+EcVhlERpslscsspsss.t..phpp.-shc..lslpEEcsslpKcsVlpEEVplpKcssp-scplp-slR+Ecl-l	........................h.lpEE+LpVsKc+lpsGc.Vcl+KcVlp-ppslpVPVc+EElhlE.Rp.slsctsssss..............................t.............h......p-..psh.c.........lslpEEpssVsKcsVshEcVpltKcthp-scplstplp+Epl-l...................................	1	67	126	161
+9390	PF09558	DUF2375	CHP02922; 	Protein of unknown function (DUF2375)	TIGRFAMs, Coggilll P	anon	TIGRFAMs	Family	Two members of this family are found in Colwellia psychrerythraea (strain 34H / ATCC BAA-681) and one each in various other species of Colwellia and Shewanella. One member from C. psychrerythraea is of special interest because it is preceded by the same cis-regulatory site as a number of genes that have the PEP-CTERM domain described by PEP_anchor (IPR013424).	21.80	21.80	22.10	65.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.40	0.72	-4.13	6	23	2009-01-15 18:05:59	2007-05-04 16:31:02	5	1	22	0	10	13	4	70.60	75	92.22	CHANGED	MpsspssVTVLYY.-APsGLlMHNtVlsuLslScsGRVMIPppFR+GKSIIAVLEGECcILNSLGERVauQt	..MQAsQATVTVLYY.DAPVGLIMHNuVLssLPVSEuGRVMIPASFRKGKSIIAVLEGECKILNSLGERVFAQ.A	0	3	5	7
+9391	PF09559	Cas6		Cas6 Crispr	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The Cas6 Crispr family of proteins averaging 140 residues are characterised by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus [1]. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes [2].	22.80	22.80	27.20	121.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-10.98	0.71	-4.58	10	43	2012-10-01 21:23:39	2007-05-04 16:34:45	5	1	41	0	20	51	26	199.20	32	90.31	CHANGED	lDLsFslpGcsLPhDHuYhLhSALschlPtL+-hsshGIpsl+GsssssG.......llhLo+co+LhlRlPtsplstlhsLsGpsLcluGcplc.LGss+l+tLpPsssLauRhVl..h+sth-E-sFLpuspRpLcshslps+thls....G+..RcTl+hsptsllGauLhlcsLusE-SL+LQpcGLGu+RphGCGLFlPcKsls	...lDlhFslpGpsLPhDHuYsLhsAlpc......hl....PhLp-...p..sslu....lpsIpGssspsG..........hlhLocRo+LplRlPtcpls.t.l.h.s.LsGpsLclusatlp.lGtscl+sLpshssLhuRhVs......hcstp.-tpsFLcsst+pLpplslpsphhls.........G+..........c+slpht....sts....lhGauLhlssLst--SlcLQppGLGu+R+hGCGlFlPpKp..t....	0	10	17	19
+9392	PF09560	Spore_YunB	Spo_YunB; Spo_yunB; 	Sporulation protein YunB (Spo_YunB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Spo_YunB is the sporulation protein YunB. In Bacillus subtilis its expression is controlled by sigmaE.The gene YunB seems to code for a protein involved, at least indirectly, in the pathway leading to the activation of sigmaK. Inactivation of YunB delays sigmaK activation and results in reduced sporulation efficiency.	25.00	25.00	51.20	50.60	23.30	17.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.99	0.72	-4.27	31	313	2009-01-15 18:05:59	2007-05-04 16:36:26	5	1	305	0	78	259	3	94.00	38	40.71	CHANGED	shthplPLGplhssslLushGP+IsV+hpslGsVpssh.pscFcsuGINQT+HpIhlplpspl+lllPhsocshpVpsplPlu-slIlGcVPphY	...s.thslPlGplosNsLLushGPcIPlchpsIGpVso.-l.cpchcstGINpTth..pIhlclcsplpVlIPFtoc.chpVppplPluppll.G-VPshY..	0	38	63	68
+9393	PF09561	RE_HpaII		HpaII restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the HpaII (recognises and cleaves C^CGG) restriction endonuclease.	25.00	25.00	32.60	32.50	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.13	0.70	-5.25	9	103	2012-10-11 20:44:45	2007-05-04 16:40:46	5	3	98	0	15	93	13	324.40	40	95.57	CHANGED	NKGEWSElYshF+LLuDGplahGssplcKhEslhaPIhpIhREE.pstphpY.lcsptlhhl...........sssccchplPhcsFtppApL..lLstlKssp.pcsFshsslEpFhsulshhcLc.ApSosKoDIslslac.cs..pPhhGFuIKSpLGu.sTLLNuG+sTNFhacl...pshphsssplppINulsp.toclt-Rhh.I.chGGhLcYhcltscsFpsNLhhIDsphPclLuchlhhaYtsploclpDLTcplpchNPLphc.p..ppHsFYEaKhKpFLsslALGMpPuKlWNGp.sAsuGallVcpsG-VLCYHIhs+ppFc-YLapNT+LEpuSoSRacFGplhp-NGchYFKLNLQIRF	............sKtEWuElYshh+LLuDGplhhGsschpp..shhaPlhhl.RcE.ccGp.ppYhl.ccpt..lh.l..............psppt.tplPtp-FttsA-h..lLptl+ssp..tppshs.s.c.ulEpFL-ph.sha.c........Lc.A+ocD+oDhplshac.cs.....PhhGFsl+ScLGshssLLsuG+s.sNhhhc.....ts.hpF....s....ssslsclNul.........sp....sclt-RhhhIc.chGGhLcYtclssclFcsNLhhIDhphP+lLuEhlh..hhal-..slocls..-LsEh..lpphNPLKlccp.......pcHsFYEaKhKpFLhAlALGM+PuKlasGps.sAstGhllVcssG-V.LCY.H.h.c+phFcDaLahNo+hEpuSsp..+c+aGhl.+.E..NGsaYFKLNlpIth..........................	0	7	12	13
+9394	PF09562	RE_LlaMI		LlaMI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the LlaMI (recognises and cleaves CC^NGG) restriction endonuclease.	20.90	20.90	22.80	22.70	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.75	0.70	-5.23	2	7	2012-10-11 20:44:45	2007-05-04 16:44:01	5	1	5	0	0	8	11	262.00	54	98.34	CHANGED	MsssKE+lhElFhpNVhGh.PsIpGhsh+HsGthGHWLEc+hGhossAsNcADhhGYEhKN.hTSsKTTaGDWSANEYIFcp...Ns.Fphs.....pstFh+hFGKPNpAKpsRhSWSGpPlPc...pYs.FGQIMsI-EsLsIsIhYSFppD.R.NKF-lhP.phppspl.lA+WYGhtps..S++.psLcsKlpcKFNphGWFpChhcs.ssYscIsFG+PIsFE.WhNhV-pG.laFDSGMYpGNpRsYSQWRu.NSaWppLIp-pap	.........KppII-lF+pNVhG+p...Pchs.uhN.RHDG+c..GHWLEcphGIuANAsNEADlaGYEhKN.oTuuKTTFGDWSAN.YIFcs...ps.aphs.....pspFhchFGKPNttKssRaSWSGSPlPch.sp.YshhGQhMsI--uhsIlIhYSaSpD.R.sKhsIlPspLQp-tl.lARWh...p.....p.csLcsKLpcKFNc+GWFpCppss.GsYscIsFGcPIsF-sWlpLV-pGlVaFDSGMYpGNsRsYSQWRAsNsaW-SLIs-sY..........................................	0	0	0	0
+9395	PF09563	RE_LlaJI		LlaJI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the LlaJI (recognises GACGC) restriction endonucleases.	23.60	23.60	23.80	23.90	23.10	23.50	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.20	0.70	-5.77	12	86	2012-10-11 20:44:45	2007-05-04 16:44:32	5	1	83	0	15	98	4	346.80	21	74.68	CHANGED	FVGl.hsp....sscllhsFPpththspsp.slc.tD.ttLhs....lLp+Yscppsp.....hph.stpsppppshslsshhhllcDahppG.hYpcscphhphNtpGcIsWs+TIpcspPllp....pssshYhphhsc+phps-pshlopIHcasVpcshpph..Galhsh.t.sh.phsht.h.....spshhlphLppclssTFsDcchhLhcuhhshlpppcp..scpp...haGTppFphlWEchhcplF..............sltphp....................shhs+PpWp....hsptp.spshpPDhlhhh....ccp..lhILDAKYYphthp....hcuhPsssDIsKQlhYtthlpphh........ptsclh...NhFlhPhsppsp.ht..sssphphls...hp...t.csht.l..shhlssc	......................................................................................................aVGl.h........tpphhhhhPhhh...pp....thp.....h.h.llp......sl.cap..ppppp..........h..ttstt.t.p.st.slsshh.llc.ah.p.pG..hYhpppphhppstpG+IsWs+TIpcspsllp....pssslYhchhs++ph.spschlptlathslppshpph..Galhsh..t..t..phsp.........spsh.hlph.LcpchsptFsDcchtLhp.shhs.alpppsp.hppsp....hhGTpsFphlWEchlcchh...................s.t.spp..............................phh.s+spWp........ttsp.p.p..tp.....phl.pPDhlhht.......pcp....h.a.IhDAKYYphsh...........p........hps.hPsssslhKQhsYsp..shtph................p.tplh...NsFlhPhpt..tp..........h...............................................................................................	0	7	10	14
+9396	PF09564	RE_NgoBV		NgoBV restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the NgoBV (recognises GGNNCC but cleavage site is unknown) restriction endonuclease.	25.00	25.00	32.70	32.70	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.57	0.70	-5.13	2	50	2012-10-11 20:44:45	2007-05-04 16:47:48	5	1	44	0	4	35	4	197.50	69	96.74	CHANGED	MIKLTAQQIFDKLLDEEKILSANGQIRFFLGDVDIIVKQKDVVGNIIQEWLGGWLRKREIEFDVSTNTQMPPDFFLNKKDRSRELLEVKAFNRNAsPGFDIADFKMYSDE.hhpP.h.sschh.hGYDMDDNGNVTIKDLWLKKVWQITRSMDGWAINhpsKK.........sW............Clcs..............................................A+ha	.............KLTAQQIFDKLLsE-KILsspGQI+FaLGDVsIIVKQKDVVGNIIQEWLGGWhcKRpIEF-susNTQMPPDFFL.NKKDRSRELLEVKAFNRNAsPGFDIADFKMYSDEI....IHKPYMLDVDYLIFGYD.MDD.N..G..NVTIKDLWLKKVWQITRSMDGWAINLQVKKGVVHKIRPGV..WYSIN..KKNMPMFECLEDFVSAIEETVYQNPATRHNASLWK+KFEEAYKKHYNRSISIPRWHEIAHKY.........................	0	3	3	3
+9397	PF09565	RE_NgoFVII		NgoFVII restriction endonuclease	Coggill P	anon	Bateman A	Domain	This family includes the NgoFVII (recognises GCSGC but cleavage site unknown) restriction endonuclease.	20.80	20.80	20.80	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.00	0.70	-5.47	7	72	2012-10-02 13:01:53	2007-05-04 16:59:06	5	2	66	0	17	148	64	252.10	24	71.27	CHANGED	at..hppuDcL.lhsGYlo.shulpclcpls-.php.hpIsLlsGMash-Ghsts.asshhcLpthhpcpshGsl...alhtshchHuKlYlahKc.tpsh.uhlGSANhss...suhhpcphE..sssspDs.s.spchht.lpss.l.php.sltsh.ph..........phlh-tss.hpshtshptlsppslphh.ppt....F.l.h......csst.............pSsLNh....u.sR....Gph..psRsh.Es.IplstcIsRp.........ssa..P......ppp.FpllTDDGahh.s+hsup.......ssKplsuhts............pplLG+al+sRL.hspGsl...pp..........lT+E.L	.......................................................................................................................................................................h.hhsGh.s...............................h.t.......pl..plhhGMh...Ghs.......hpth..p...l.....hptpth..tth...al..........hHuKhY.a..pp....t..h..t.uhlGSANhs.........s..p...pt.hE....hhh.h.s....t..........h....lpp...h.ph.t...l...p....................hh..p..tp....hpth.....thtt.l........p.l.t.......t.p.....h.....ls.h........cs..t..............................................................+SsLNh..h.u.tu.R.....G.h..hsRsh.Es.lhlsppIppp......................tha...P..................tpc.s...FsllTDDG...h.hps.+sstp..........sKshpopss.............phLGcW.l.+s+L...tts.h.................................................................................................................................................	0	7	12	14
+9398	PF09566	RE_SacI		SacI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the SacI (recognises and cleaves GAGCT^C) restriction endonuclease.	19.30	19.30	20.50	123.60	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.29	0.70	-5.51	3	10	2012-10-11 20:44:45	2007-05-04 17:00:02	5	1	10	0	4	12	0	348.70	27	95.43	CHANGED	MuITINHSsAppVL+cAaEcAup.oDDchpsQW.....lILuT+LpElss.R...TYpAALlTALLAKAsDsRVDPhuIpE+sssDsAYSARSLCHuVlVs.pVEtuFLEGsLGAsR.EPlNNpPFhRYspaSuI.pVcNK.uRcYLD+VLsALScIDpEchATTp..uaRALVAuLthTlsRTN+......................ssKEssAlGuAIVptSLluEpcuFVlpuH-VsR+hQAuuAuhLshsa.KE.Ilst+lNDPsRsFPhDIsVY...cDGssaLoIEVKDKslsapDLppuVSKAotuGIp+VlaLssA+A.TslsL....DcohAlERstsCtVpVsFS.VpoFs+sCFAlSPllusStl.hAF.cAIscpLIEIcV+-ssID	....tlsIs+.cpAccVLpcAacsAsppsD.shsspa......llpsspL..hss.+...Ta+YILlTALLAKATsscINPLsLQppusl-GAYDARSLCHKVlVP..FE+saLpsuLGuSN.EPFLNKP.ARascl..Sp....cNA.VRRGpD.c.lL.ptLsthc..hpssss..AFcuLssALhhtlppspc...............................tpphhhs.s.hIhphpLh.phppsal...lcspcs...GpphpAt..suusLth....ha...pE.....VtschVNp..s...Spc.suDIDVY........................c-cpllhoIElKDKsaotpDVpHAlcKsusuGhp+shFls.GP+A.splch....-cops..hppApppslhlhas.hppFs+.hhsh.sh.stpth.hsh...lhpphh-hp.pp..............................................	0	2	3	4
+9399	PF09567	RE_MamI		MamI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the MamI (recognises and cleaves GATNN^NNATC) restriction endonuclease.	25.00	25.00	122.60	122.10	18.80	18.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.03	0.70	-5.36	2	5	2009-01-15 18:05:59	2007-05-04 17:06:57	5	1	5	0	0	5	3	274.20	30	84.58	CHANGED	LGSLp.ppc..LlcDLaVDLht+.pV....WAAlTtQoAQschGYIuQalsSlVhG.PG..pGhRGK.....sD-hA-................GStVp.........uuANIptsDcs+W...lG..cDsEa..........tEhLt.PhhaYLll.c.pslpcPssIRhphWplDu.psG.hhsLh-ha.....sS+pGtsaN.......FpLh.Pl.............L.apshll.Dsplphtshst.p.s.HhPLs....PlT..uRopsLphGthtthssRL.....hNsuchVLhps..........D.sslhsulhtPhsshDhAshS.hto.-A.s-thS	.........h.toLEsS-p..LIK....DLYVDL+++lss....WStITsQTAQA+hGYIGQHLASlVTGhPGstSGARGcDLs..ssDhuEIKoC.RVDQLspCpsCGosVpthEppCPsCuSTNIcRcDDSKW..LlulRsDsEa..........-ElLs..Pc+aYLlLFDapDl..pDs..csIRIpsWcVDupEc.GhsaC.Ll.DYYh.NI...Kh.uS++G...APaNLaPapacFtLp+Pl.............LIFcusIl.sDs..pIpht....lhPs.p.sh+hPLs....Pls..uRspslphsthtth.sRL..............................................................pt..hh...................	0	0	0	0
+9400	PF09568	RE_MjaI		MjaI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the MjaI (recognises CTAG but cleavage site unknown) restriction endonuclease.	21.60	21.60	26.80	36.70	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.90	0.71	-4.72	7	42	2012-10-11 20:44:45	2007-05-04 17:08:48	5	1	37	0	16	44	4	169.30	31	84.26	CHANGED	s.llNhAsphhptshP+lVGthSELI+Ehp...s+ohc-W+EaYhp+..hp-pIsctscKlhhhlpphhpu.lpplccEslcpalc-LVIs+Ta-Ghhhp.csILpplAcc...hssphc.AssE.-cspslDGaI....tpIPlpIKPhoa.sppsplsE.hphphIhYcppcshhhl.hscsh	....llNhAsphhphs+PcsVGthSElI+Ehp..........s+ol......cEWcpaYhp+...............hsEslcchscKlashlpchh.....pu.lpploc-....DshpalcsLVIs+TasGhhhp.psIhppltpc...........hshpa..c.AssE.-cshsID..h.aI.....tthslQIKPhTY.......t.hsE.hph..h..ppppp.....h...........................	1	7	12	15
+9401	PF09569	RE_ScaI		ScaI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the ScaI (recognises and cleaves AGT^ACT) restriction endonuclease.	25.00	25.00	40.70	40.50	22.20	18.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.31	0.71	-4.81	4	14	2012-10-11 20:44:45	2007-05-04 17:09:11	5	2	14	0	2	13	2	172.00	47	93.08	CHANGED	SPYtuhsEEcW.plTcpLIp-aPLSt-hIlphVLuSWEsIFoS+hGs.thpIGpslFPsPQhhGhlLcsLIshcltst.ss.Wpu-psp.-KDlVhhhs-hYSIElKTSSsccpIaGNRSaG..pspcuh..KSKsGYYLsINFEKap-s.sLcP+IphIRFGWLDaoDWluQputTGQQASlssphtpsKLlsla	..SPYtslspc.WhuhTccLIcpHPLStcpIVplsLcSW-sIFoSplGs..hpIG+shFPsPQIhGhlLHtLIstplpsca.s.Wpu-csth-KDlVhIhschYSIElKTSScsc.IaGNRSYu..p.spsuh..KSKsGYYLsINFEKF..s..phcPcIphIRFGWLDaoDWIuQpAuTGQQARLsscs.psKLhhlY.....	0	0	2	2
+9402	PF09570	RE_SinI		SinI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the SinI (recognises and cleaves G^GWCC) restriction endonuclease.	20.10	20.10	20.70	99.20	19.50	17.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.36	0.70	-5.36	3	15	2012-10-11 20:44:45	2007-05-04 17:11:24	5	1	15	0	6	17	15	215.10	37	92.89	CHANGED	FlQNAAElAKpsMDsl-PSLSEKFTlVI+FLSDNP-usSshRGKc.RssVGs-EaIphLAQNFp-G.RcP+pPsPPoTIPDElVSVVLNVuF-lPpEpLN+IKEpHRLSMuAENIVGDLLERYLAEVLEPsGWIWCSGohVKAVDFI+pDsE.ssWtsLQVKNRDNTENSSSSAIRcGTPIKKWFRTFSK+cuTNWDNFPsphuucsLNEcGF+sFVEpYLccl	..........................................................................................................s..p.pL..tF..lhpaLsp.Pp.hS.hRuKp....p.pVhp..cEhlphhAppYacu.RpschPt..P...pTlPDEhVShlhp.hsashoppplppI+hpHphSMuAENhVGsLLERYLssVLcspGWhWCsGshVKAlDFlphssc.s.WhhLQlKNRDNTENSSSSAIRsGTsI+KWaRohS+ssp......T.......NWsslPp.hp....uhsLsEpsFhtFVcpYl.t.p............................................	0	2	5	5
+9403	PF09571	RE_XcyI		XcyI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the XcyI (recognises and cleaves C^CCGGG) restriction endonucleases.	25.00	25.00	46.20	45.70	18.80	18.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.90	0.70	-5.57	3	13	2012-10-11 20:44:46	2007-05-04 17:12:37	5	1	13	0	4	13	0	292.30	44	93.16	CHANGED	PsPcsQI-FutuL-cLRplaLQpALLcTV+chDIucLDcELuKYVPsuDLQpLApYGLRAEllFsVPsVLEANP+LIGYYRLLLGYSQKcFYstD+GLGhGsFKSMEcKGKIuKAtpPcIcDLClAFsASAStLLsGlGhlRISRELLDDLTLLTLGPQLRGGRNNslGhAGh+hVFEIIREIVAPAIsESc-ouIVLoNAAGRsVTIEFuuDPDIIIREKlcsp+aKNslAIEVKuGTDlSNIHNRLGEAEKSHQKARp+GFTECWTlVNsuNIDLVKARsESPTTD+FYpLohLsDKussEYADFRcRIlALsGIP	..................................P.PchQIsFh.tLcchRthhLQpALh-TVcchDIspLDcpLtcYVssucLtpLApaGLRuEllFsVPsVLcsNP+LlGYYRLLhGaSQKcFYsts+GhshGhFKSMEpKGphspsttsclpDLChshstsuStLLsuls...plSpcLLDDLTLLTlGPQLRGGtNNp+GssuhhhVFEIIR-IVup.u..h.sEs...cp.stIplssAsGRplhIEFAsDPDIlIREchp.ppa+NllAIEVKuGTDsSNIHNRlGEAEKSHQKA+tpsaTECWTllsVtplDh.hAppESPoTsRFYplotLs.psssEYtDFRcpllulsuIs.............................	0	4	4	4
+9404	PF09572	RE_XamI		XamI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the XamI (recognises GTCGAC but cleavage site unknown) restriction endonuclease.	25.00	25.00	43.30	43.10	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.69	0.70	-4.93	5	29	2012-10-11 20:44:46	2007-05-04 17:13:06	5	1	28	0	9	32	4	214.40	35	79.36	CHANGED	TuNLT..uI...TP-lL.csaPpsLs.sLRMoTuPPIAcDRLlGLAchS.sLVcSlE.cs+LPs+Mcut.LcpcLcKlssVIp+hlDPDlFsWhscGcsPTccERchAATIVADRLCGAlAsPIlRNAQERR......QLAsIKSWLcARGYTQlssuAu..lNSM..sPGTFoFRtNlsV....Gs+..VNIPVDAVVps+Du+ptthPhhIEAKSoGDFTNTNKRRKEEAsKhuQLplp.YGpplsh.sLFLCGYFcoGYLGYuAAEGLDWVW	...................hp..tl...pst.l..t.s.hls.tLRh.suPPIucDcL.slus.....lpshp....thL..p.ps......Lp+lhsllp+hlD.chFsWhttsttPospphc.AAhlsustLhuA.......R.ApE+R......Q.shlcpaLcshGasch.tsu.....hpsh..................PsshpFptps.l.......Gpc......sDlVlt.tcs+.....hhlEsKsusshTNosKRhpp-.Ashhsphhhp.aGpt.hh.shhLsGhFcst.Lt.ttupGlshhW................	0	0	2	5
+9405	PF09573	RE_TaqI		TaqI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the TaqI (recognises and cleaves T^CGA) restriction endonuclease.	25.00	25.00	44.80	44.70	19.10	17.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.78	0.70	-5.25	4	13	2012-10-11 20:44:46	2007-05-04 17:14:29	5	1	10	0	3	15	0	199.50	46	95.09	CHANGED	opAQcALEAFEcFLcuLDLESYppKYRPIKTVEQDLPRELNPLPDLYEHYWKPssssPpFPsFEEFF-pWW-KRLR..PLDEFIRKYFWGCSYpFVRLGLEARLYRTAlSIWTQFHFCYRWpASCpLpLpAu.ELDuQGIDALIp.s.p-p.lGIQIKKETYRSEARutNRFLRKpp.soALlElPYTLQo.EELpcKApRARocp..EsYpLWsKVApHL-+LPNGFVIFRESYVKclEsFLpcNAsTLoGLI	..............pcsLctFEcFLtuLDL-pYpp+hRsIKTVEQDLP+EL.PLsslYcaYWcs...p.pF.sFE-aF-paWc+......+L+......P.LspFI+KYFaG..CShtFV+hGhcARLYRThlSIhTQFHFCYhWps.C.....p.....L.Lpus.ELDtpGIDAhlp.h.pt..lGIQIKK.oYRpEA+stsRFh++pp..tsuLlElPYsl.s.EELpcKhtpsRscp...csYp..hchh.p+.h.+L.NGFVlFpEsYl+.l..............................	0	3	3	3
+9406	PF09574	DUF2374	Short_TIGR02808; 	Protein  of unknown function (Duf2374)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This very small protein (about 46 amino acids) consists largely of a single predicted membrane-spanning region. It is found in Photobacterium profundum SS9 and in three species of Vibrio, always near periplasmic nitrate reductase genes, but far from the periplasmic nitrate reductase genes in Aeromonas hydrophila ATCC 7966.	21.40	21.40	22.30	63.50	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.13	0.72	-4.34	11	107	2009-01-15 18:05:59	2007-05-08 12:46:36	5	1	106	0	12	42	1	42.00	78	97.19	CHANGED	MSTLESVIWHlLGYuAMPVIILuGFluVAsVSIhLLuhsKDK	MSTLESlhWHVLGYSAMPVIILuGFlGVAVVSIhLLuhTKDK......	0	1	4	8
+9407	PF09575	Spore_SspJ	Spore_SspJ; 	Small spore protein J (Spore_SspJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Spore_SspJ represents a group of small acid-soluble proteins (SASP) from Bacillus sp., which are present in spores but not in growing cells. The sspJ gene is transcribed in the forespore compartment by RNA polymerase with the forespore-specific sigmaG. Loss of SspJ causes a slight decrease in the rate of spore outgrowth in an otherwise wild-type background.	25.00	25.00	88.60	88.30	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.20	0.72	-3.76	3	23	2009-01-15 18:05:59	2007-05-08 12:52:21	5	1	23	0	5	12	0	45.90	79	96.88	CHANGED	MS.FFNKDKGtNSEKD+NsVcGALEDAGpALKGDPLQEAVQKKKNNR	Mu.FFNKDKGKpS-K-KNVIQGALEDAGuALKDDPLQEAVQKKKNNR..	0	1	2	3
+9409	PF09577	Spore_YpjB		Sporulation protein YpjB (SpoYpjB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These proteins are found in the endospore-forming bacteria which include Bacillus species. In Bacillus subtilis, ypjB was found to be part of the sigma-E regulon. Sigma-E is a sporulation sigma factor that regulates expression in the mother cell compartment. Null mutants of ypjB show a sporulation defect, but this gene is not, however, a part of the endospore formation minimal gene set.	20.40	20.40	20.40	22.30	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.42	0.70	-4.79	10	157	2009-01-15 18:05:59	2007-05-08 13:35:37	5	2	156	0	27	110	0	227.20	45	87.38	CHANGED	uhcELscLSDslLQLsKpp+YEEAlQVLpYFpcpFhus-hcppp..lTssplRplTluY-cAl+uLpppchscpEKl+ssspFRLllDAlsScpcPLWsphEcPlMcuFushKcAspppDspsFpcphNpFloLYslIYPSLpIDlssspLppVssHlshlEphc..phopsopp-+LsllcpDLpslFDpVccD-ADPSLLWVIloTGGIIlhTLTYVGaRKYKuEKcKcKsR	............................................................pWpELssLhD-uLQLVKcsc.EcAlQVLpaFS-QFhhpssc..ccp..lTs-plRlISLuY-cAppSLsppslscp.Klcslh.tLpLAVDA.sSKaQPLWhEhEtplM-AFSphEKAhpKc...Ds...spFppoLNsFLpcaslIYPSLhIslPEs-lQRVsuHlSY....L-.ch.c.s.sh.Lc.s.cus....phQ.L.ull.+uDLQ+lFcsVK.......KD.......Eh....s......P......SL.........I......Wh.MshTGGlIlhTLTYVGWRKYKGE+EK+Ksp...........................	1	6	17	19
+9410	PF09578	Spore_YabQ		Spore cortex protein YabQ (Spore_YabQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This protein is predicted to span the membrane several times. It is only found in genomes of species that perform sporulation, such as Bacillus subtilis, Clostridium tetani, and other members of the Firmicutes (low-GC Gram-positive bacteria). Mutation of this sigmaE-dependent gene blocks development of the spore cortex. The length of the C-terminal region, which includes some hydrophobic regions, is variable.	21.00	21.00	22.50	22.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.52	0.72	-4.03	38	379	2009-01-15 18:05:59	2007-05-08 13:55:22	5	1	375	0	85	295	6	79.20	32	46.51	CHANGED	hlsslhsGhhlGhhaDhY+..hh+phh+hp.+hhshltDllFWl...ltulllFhhLhhsN.GplRhYlaLullhGhsl...Yhtllup	..............hlhhlhhGhhlGhsaDhYp..hhhpth.....cpp...+hh..shlpDlLFWl...ltulhlFhhLhhsNpuclRhYlaLullhGhhh...Ytphlp.............	0	45	70	75
+9411	PF09579	Spore_YtfJ		Sporulation protein YtfJ (Spore_YtfJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this family are encoded by bacterial genomes if, and only if, the species is capable of endospore formation. YtfJ was confirmed in spores of B. subtilis; it appears to be expressed in the forespore under control of SigF.	25.00	25.00	25.10	25.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.81	0.72	-4.13	71	712	2009-01-15 18:05:59	2007-05-08 14:01:05	5	1	496	0	166	461	6	87.30	40	62.67	CHANGED	lcssD.slIlPlu+VuFGFuuGGu-hpspp.................tppt..........hGGGuGuGlulpPlAhLVlp.s.....spl+llsl.spps..hl-+ll....-hl.Ppll-+	..........lpssDGslllslS+V..uF..GFuAGGS-apssp....................t.ttps.............FGGGSGuGVSIsPlAFLVls.s.....ssV+lLpl..spss....hh-Kll.....-hsPphl-K.........................	0	73	135	147
+9412	PF09580	Spore_YhcN_YlaJ		Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic, 40-residue C-terminal domain.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.02	0.71	-4.16	52	715	2009-09-10 23:13:51	2007-05-08 14:11:15	5	3	229	0	145	527	0	161.00	19	84.30	CHANGED	hhhhhluGCsssppsp.tt...............................................................................................................................................sstsst.thsp..hphpp.tsppt............htstpcpclAcclschss.plspVccAsslVs...........................................sppAlVulchp.t....t.......spsc...pl+ppVpcslcshssphppVhVouDs-hhpRlcshuppl.psGpsh..pshhp-lsphl..p+lhs	..........................................................................................................................h......................................................................................................................................................................................................................................................t..t....tp......hphpphttpp.........................pstpsspchAcplsshst.plssVpcusslVs...........................................sp....pshVulcsc.tp.....p.............................................stsc..pl+ppVtcplps.sP...p.hslhVosD.chhpclcplsppl.pp.s..p.sh...st.h.tpplstlhtch................................	0	50	104	116
+9413	PF09581	Spore_III_AF		Stage III sporulation protein AF (Spore_III_AF)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family represents the stage III sporulation protein AF (Spore_III_AF) of the bacterial endospore formation program, which exists in some but not all members of the Firmicutes (formerly called low-GC Gram-positives). The C-terminal region of these proteins is poorly conserved.	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.05	0.71	-4.43	40	411	2009-01-15 18:05:59	2007-05-08 14:19:16	5	1	379	0	93	314	6	174.90	20	89.74	CHANGED	llhllhsshlEhLLPsush+KYl+hVlGLlLllllLsPllpLhp.p-hshththhpp.......pp...ppphppptcchpspppshll-p....hpspLcpplccplc...pphshphtclplphsps.pptt.......pIpplsltlpp...tp.t........................................................pVc.lpIst..................tp.stppttpspptpclcphlup....hapl.sp-pIpVth	..................................................hhllhsshlchlLPssshpKYl+hlluLlLllllLsPlhpl...hp.pc.h...s..h....h.t.....hsp.......................tttt.p..pp...l.p.pp.pcch.pttp..c.shslcp.....htpphccplppthp........pp.hshph.clpl.hs....psttp.p............plpp.l.ltlppt.t.tp..tt..t.........................................................plc.lplst.................................................t.t..tt.pt.t.c....hpphhup......hhpl.t.cpIpl.................................................................................	0	47	76	82
+9414	PF09582	AnfO_nitrog		Iron only nitrogenase protein AnfO (AnfO_nitrog)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry include Anf1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) and AnfO from Azotobacter vinelandii. They are found exclusively in species which contain the iron-only nitrogenase, and are encoded immediately downstream of the structural genes for the nitrogenase enzyme in these species.	23.90	23.90	23.90	57.20	23.30	23.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.96	0.71	-5.18	14	61	2009-01-15 18:05:59	2007-05-08 14:24:52	5	2	51	0	39	60	0	200.20	27	92.49	CHANGED	hcIAVhlsppGphsohh-sGhltVYpcssspWplt+ch.hs.lssspulstl+ttlsshlspLscC+lhlupsspGlsYuhL.-chuhplWchpGpsh-hLDtVhccEp-pt.cptt...............................tssshshshPlchG.s...GcaplsLpcl.ppsscloSKQlLlPFLcsssFpcL-llCsHlPpWhsp-lsthsLch-s..pphs+pslp	...cIAValscpGpssoh.csGh.ltlap+.psspWphhcch.hp.l.ssstulsplRpphppllptLscC+lhlupplpGlsYshL.-chGhslWch.pGps.-..hLDtlhccEpcptpptt.................................ssshsh.tPhchs..s...GpaplsLpcl.t.psssloSKplLlPFLcpssFppLEllCsHlP.Wh-pcltthsLphch..pt.......h............	0	17	30	34
+9415	PF09583	Phageshock_PspG		Phage shock protein G (Phageshock_PspG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This protein was previously designated as YjbO in Escherichia coli. It is found only in genomes that have the phage shock operon (psp), but it is only rarely encoded near other psp genes. The psp regulon is upregulated in response to a number of stress conditions, including ethanol, expression of the filamentous phage secretin protein IV and other secretins and heat shock.	25.00	25.00	55.60	55.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.28	0.72	-3.91	13	608	2009-01-15 18:05:59	2007-05-08 14:26:17	5	1	604	0	44	195	2	64.50	71	79.78	CHANGED	MlELlFllsFhlsLllTGlSllGllAAlsVAhslMhluGMhulVIKLLPWLlLhllslWlhRshp	.MLELLFVlGFFlMLMVTGVSLLGIlAALVVAT.AlMFLGGMLALMIKLLPWLLLAlAVVWVIKAl.t..	0	1	7	25
+9416	PF09584	Phageshock_PspD		Phage shock protein PspD (Phageshock_PspD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are phage shock protein PspD, found in a minority of bacteria that carry the defining genes of the phage shock regulon (pspA, pspB, pspC, and pspF). It is found in Escherichia coli, Yersinia pestis, and closely related species, where it is part of the phage shock operon. It is known to be expressed but its function is unknown.	25.00	25.00	27.70	29.20	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.16	0.72	-4.27	7	520	2009-01-15 18:05:59	2007-05-08 14:33:02	5	1	516	0	28	113	1	63.30	79	86.29	CHANGED	t+s+sG..LKhhuKlhlhsALpYGPAGsAGWhVKoVuRKPL+hLLAhsLEPlL++hhs+lutpahp	................QKVKPG..FKlAGKLVLLTALRYGPAGV...AGWAlKSVARRPLKMLLAVALEPLLSRAANKLAQRY..Kt.	0	1	5	17
+9417	PF09585	Lin0512_fam		Conserved hypothetical protein (Lin0512_fam)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a well conserved motif GxGxDxHG near the N-terminus.	23.40	23.40	23.50	24.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.43	0.71	-4.51	22	222	2009-01-15 18:05:59	2007-05-08 14:40:49	5	3	169	0	69	202	119	110.20	39	85.68	CHANGED	pphhlEhGhGsDlHGQDhTKAAtRAV+DAlp+sSlsuhhc.hhsh.shspMpVpVclGVscP..-pVDt-tltshlPaGp.ssVpllpGGL......sltchss.s-shlIAsAAVpVu	.......hlhlEhGhGsDlHGQ..DhTKAAtRAV+DAIp+NSlsultp..h.....lsh..s...hp.sMhVplpluVs.......ps..-plDp-tl+ullPYGp..solcshpGGh.s..uhtltchs-ts-.hhIssAuVpV.........................	0	25	51	63
+9418	PF09586	YfhO		Bacterial membrane protein YfhO	Coggill P	anon	Pfam-B_2727 (release 21.0)	Family	This protein is a conserved membrane protein [1]. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	28.50	28.50	28.50	28.50	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	843	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.37	0.70	-6.52	56	1820	2012-10-03 03:08:05	2007-05-08 15:29:27	5	4	1236	0	257	1471	211	637.40	21	83.13	CHANGED	u.hllPhllhhhhhh.....hthhshuspslhssDhhpQYls....Fhthhpptlh......sssshFYoastGLGushhuhhuYYl.hSPhshlhhhFs..............hpphspuhhllsllKhulhGLohhahhpphh........tph....hhslh.....huhsYuLsuasls.phslhW...hDshIlLPLllhGl-+llcpp+hhhahlslulhl.lsNaYhuYMhslFhhlYhlhph...h.......pshpphh.....pthhpahhsSlLushhSulhllPshhslhs.spps.sp...sh.hthphshhchhs+hhhGsashpph.......s.laluhlshlhhlhaFht+phph+h+lhhsllhhhlllShhhphlshhWpGhptPsha.aRaualhuFhhlhLuupslp....phpph.........hhphhhshhllhtlhh.hshhhp.ppt...phhp.....h...................................................slhhlllhhlllh.hhh..........tph.hhhhhhllhlhhhh-hshNhhhslsphs....hsspp.asshhpshpphhphhp....ppsss.haRl-phhsps......t..........N..-shhhsYpGlStaSSlhspsh.shhs.....slG...tssssphphtssohlhDuLhulKYhls............................................pspphplYcNp.sLPluasssshh......pchchpp.....tssls...pQsthLpulsspst.............................................phFps.........................p.sphphpssptts..shht.st......................spstssslphshs.sssssshYlphs.........................................s.sppshslpV.Nspshppp...............pstlhsluhpscsp.plplsl......hsps....phplsphplhshsh.pshppshpplpp.pthphtphp...ssplpuslss..pcsshLhhoIPYs+GWpsplsGKplphp+..sp............ssFhu..lslspGppplplpYhPshhhhG..lllS	.......................................................................................hlshhlh.hhhh.......t.h..h.....u...t........h......s.Dhhp....Q.hh.........a...h.hphh...........t..p...h.......as...h.s..ul.Gh.sh.ht........uYYh..hu.h....l.h....hh...............hp.hs.shhhh...hhl+hhhhhhshh.h.hphhh...........................th............h.hhhuh.Yuh.shhh...............a......hss.hhhhPLhlh.ulch.h.h............p....pp....+......h...h...hh....h.s.....h...hhh...h.p.....N......a......Y.....h.....ua..hhs.....lhhhhahlhth....................................ph..hp..hh......pthh..hhhhshlu....sh.uhhhhhPs...h..sh.p.ptp.t.......................................................................h.........h..........p..h..p..........h.....h.............h.......................s.........................................h..ah...hh........h.s....h..lh....h.hh.....h..h..........p......hp..h..h..h.......hhh.....hh....h...hhh.h.hh...s.......h........h.s.......ha.......p...uh..p.P.t...................hR...as...alh.sh.h.h.hsh.hhp..........phpph.....................hthhh...hhh..hhhhh.......hhh...h.h.....t............h.........h.h.h...............................................................sh...h.h.h.h.hhhh.hh.h.h......................................................h.h.h....hh..h..hhh.h.h..........h.......h.....s.................hpth..................p.t.h..tp.....h....t..........t.......t.h..............................ttt..h.Rhp...h.....t...........................N....sshh.ht....atuho....asSh.hstt.....p.hhp.............ths.........tp.s...ht.......s..sp.....h....slhslph.h.........................................................................................p.t......ph.hhpNp..t.hshu.h.hspp...h...........p.p...p.ht............sht.ppt.t.hhpths..p....................................................................................hhp.......................................p.t..ht..t..t..............................ttt.hthp.h.......hp.....t.....tph..ah.h..............................................................................tpthpl...l...st...p...............................hhsl.s........t...tp.phplph.............tt....thpht...thh....t...s....pt.hp......pthpph.pt............h...p.......ph........ps.plthshss..ppst.....hlhh.o.l..P.Y..sp.G...Wpsh...s.G.c..p..lp.hpp..sp............tshhu..lpls.t.Gp.p.plphpahP.hhhhGhhho.....................................................................................................................................................................	0	106	190	230
+9419	PF09587	PGA_cap		Bacterial capsule synthesis protein PGA_cap	Coggill P	anon	Pfam-B_1441 (release 21.0)	Domain	This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.63	0.70	-5.02	181	2048	2012-10-02 19:15:56	2007-05-08 15:48:07	5	29	1542	0	483	2755	332	235.10	26	60.66	CHANGED	slshsGDlh.hs........psh.p.h..t..................................shs.ha.ttlt.s...hlppu...D.lslsNLEssl.........................................ssssp...shss..h.....htapsssph.sssLppsGh..c...slsl.ANNHshD....aGtpGltcTlp...tLc.psG...lthsG...suts.tpupp...hlhph........pGh+luhluas............................................................................................................ppltpc.......lpps+...p............sDlllVshHW..G....tE........hptt...........P.sspQpp............hA+thlD.u.....G.ADlllGpHPHVlpshE.ha..........csp.......................hIhYSLGNF.lhst	.............................................................................................................lhhsGDhh.ht........t.t.h.t.h..t..........................................shp..a..ttlt......hl..ppu....D..l.s.hsNhEssl.............................................sspst....hsth..........hapsss.ph..hp..sl.......p.s.s........G...a.c....slsl.ANNHshD....hGh...p...Glh.s.T.lp............tl.c....p....ts...............lth..h.G.............shp....s........t...t....c..s........p.p..s..........hl.h.ph............pGh+luhluashsh.ssht.sh....s....t............................................................................................................................................................spltpp...lccs+....p..........puDl.llVhhHh.....G.......sE.........................a..p.p...........................P...sppQpp.......................................................hu+th...l.-..t........G...A...Dl.lhGpHPH.V..l.p.s.hE.hh................................ptp.................................hI..h..YShGNFl.s....................................................	0	197	343	427
+9420	PF09588	YqaJ		YqaJ-like viral recombinase domain	Coggill P	anon	Pfam-B_3587 (release 21.0)	Domain	This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit [1].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.06	0.71	-4.24	97	1553	2012-10-11 20:44:46	2007-05-08 15:50:07	5	18	969	13	375	1400	442	140.60	24	46.91	CHANGED	-WhphRptt........l.suS-sus.................................................hhG.hs..h.....ps.shplhhccssp..............................ptspsht....hGpphEshstphappppG..........hplpt.......thh........p.shhtAShDGhs..................................................................................................................................thlEhKsst....t..hht....................ttl....PptYhsQ.....lQtthhV........o.utc	...............................................................................WhthRhth..............l.suS-sts.....................................................llu....hs...............ts....hhphhh.ph.hsp.............s..........................................................................psp.sht....h.GpphE..........s..ut..........p....ha..ph.p.pu.........................hplpc..............p.shhh+...........spp.h...h.u....u.osDGls.........................................................................................................................................................sshLElK..ssh...............s.p..hhph..pht....................................tl.................ttYhsQlQhphhlos..t............................................................................................................................................................	0	189	280	336
+9421	PF09589	HrpA_pilin		HrpA pilus formation protein	Coggill P	anon	Pfam-B_3574 (release 21.0)	Family	HrpA is an essential component of the type III secretion system (TTSS) which pathogens use to inject virulence factors directly into their host cells, and to cause disease. The TTSS has an Hrp pilus appendage for channelling effector proteins through the plant cell wall and this pilus elongates by the addition of HrpA pilin subunits at the distal end [1].	25.00	25.00	26.00	25.90	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.82	0.71	-3.66	6	71	2009-01-15 18:05:59	2007-05-08 16:00:00	5	1	55	0	4	39	0	119.80	48	98.42	CHANGED	M........................s.hppLsshGptslNslGGA....................................hQGlNslsSusshpsNll...................usT..GsopSscAppcuhucu.......................................DAsuA+L..........................................................uhQucEstK+pp.ssLsAhpAu+EDuoNKKISuTtpNApGIsY	....................h.....slhSSLosAGpulVNslGGA....................................hQGlNoVcSuADRphuLh...................psT..GSoDSlDAspsuluKG.......................................DAcuAcL.........................................................puhusEEsuhhREpSMLAGFEstKEsLoNQIVAuKIcNuV.VQF.	0	0	1	3
+9422	PF09590	Env-gp36		Lentivirus surface glycoprotein	Coggill P, Bateman A	anon	Pfam-B_3269 (release 21.0)	Family	This protein is found in feline immunodeficiency retrovirus. It represents the surface glycoprotein which is found in the polyprotein C-terminal to the Env protein.	19.30	19.30	19.90	21.70	18.70	16.70	hmmbuild  -o /dev/null HMM SEED	591	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-13.04	0.70	-6.31	5	1139	2009-01-15 18:05:59	2007-05-08 16:06:50	5	2	10	0	0	929	0	233.30	65	86.41	CHANGED	FuQNRQWIGPEEAEELLDFDIATQloEEGPLNPGVNPFRVPGIT-pEKQ-YCsILQPKLQELR-EIpEVKL-E-NAGKFRRlRYLRYSDEpVLSllYLLl.GYl+YLhsRNKLGSLRHDIDIEss.scEpFsK+EKGsTlNpKYCRlCCIGsssLYLlLFIGIGlasGossAQVVWRLPPLVVPVE-oEIIFWDCWA..PEEPACQDFLGAMlHLKAshNISIQEGPTLGpWAREIWATLFKKATRQCRRG+lWRRWNETITGPhGCANNTCYNlSVlVPDYQCYlDRVDTWLQGKlNISLCLTGGKMLYNK...-TKQLSYCTDPLQIPLINYTFGPNQTCMWNTSLIcDPEIPKCGWWNQsAYY....NSCKWEQsDVKFQC........QRTQSQPGoWlRsISSW...KQRNRWEWRPDFES.EKVKISLQCNSTKNLTFAMRSSuDYu-VsGAWIEFGCaRNKS+pHopARFRIRCRWNsGoNTSLIDTCGscQNVoGANPVDCTMpuNTMYNCSLQcGFTMKIEDLIVHFNMTKAVEMY............NIAGNWSCsSDLPouWGYMsCNCTsosSo....hsKM+CPsc-GILRNWYNPVAGLRQALcKYQVVKQP-Y	..............................................................................................................................................................................................................................................................................................................................................................................................................AYY......NuC+WEps.sVpFQC.........QRTQSQPGoWhRsISSW...+QRNRWEWRPDFES.EKVKlSLQCNSTKNLTFAMRSSuDYG-VsGAWIEFGCHR..NKS+hHo..-ARFRIRC+WN.GsNsSLIDTCGp..s....NVoGANPVDCTMtAspMYNCSLQcGFTMKlEDLIhHFNMTKAVEMY............NIAGNWSCpSDlPtsWGYMsCNC..T..................KMtCPpppGIlhshYssshh.h.tLt+Y..lVKQP-Y................................................	0	0	0	0
+9423	PF09591	DUF2463	UPF0328; 	Protein of unknown function (DUF2463)	Coggill P	anon	Pfam-B_3132 (release 21.0)	Family	This protein is found in eukaryotic, parasitic microsporidia. Its function is unknown.	22.00	22.00	55.00	54.50	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.48	0.70	-4.74	23	38	2009-01-15 18:05:59	2007-05-08 16:07:07	5	2	2	0	34	38	0	199.70	39	75.93	CHANGED	FPhhhYhIhsKDsF-ps.hLRFIslLhPaSYSAlQahhLLaoN...W+uspKPEshLaphLYahLNlLLlsFulISILSIIshsl.....scWpss-s.hhaSllLPSFhlssTYLLSTSCsLVPGpIuFTDTGIslLIDlLILLs.llsllh..hhccsc....Yh.a.ulhSslLlLl....RhL+E+ahP..SccS..........u.PousWRVulhllILlLushlYshhshssl	....aPhhMYhIhsc-pFccs..FLRFIslLhPhSYSAlpahhLlaoN...W+uppKscshLpshLYahLslLLluFulISILSIlsFsl.....s.cWcs..scs.hhaSl.lLPShhlsssYLLSTSCsLlPGpIuFTDTGIslLIDlLILlsslssllh..hhccsc....ah.ahullS.lLlLl....RlL+E+hsP..sccS..........s.PossWRlulFllILlLuhhlYshhshhsh....	1	34	34	34
+9424	PF09592	DUF2031		Protein of unknown function (DUF2031)	Coggill P	anon	Pfam-B_2630 (release 21.0)	Family	This protein is expressed in Plasmodium; its function is unknown. It may be the product of gene family pyst-b [1].	20.70	20.70	21.40	21.60	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.66	0.70	-5.20	44	121	2009-01-15 18:05:59	2007-05-08 16:18:06	5	3	5	0	117	121	0	178.40	43	83.33	CHANGED	RlsILK.YVhFS.......IlICSF...EYuKN...ELYhlN......-RsIhLERNlINFRNNRILADsDNpFDLN-FYQSTLSLANQhN-hs-....Ds........cEItaLRNhIDSHIKKHKEsNTL.DLpNVD.pKTKKLIscL+KELEEl......KKElDN..KpNuELuIQPIpDKpIhKKDENsSVSEcEsF+QLENp.s.lt............E.NcIs.SSsphhc.Khpp+h+..Kttpphlhps..lhhlshshslh.lsG....hh.lhhllls	.....................................thhp.hlhas.......lhlh.F...casp.s.....................ELa.hs......tttlhhERNlIsFRNNRILussDNpFDLNpFYpSTLSLssQhs-hs-........ss.......cEIhhlRNhIsS+IKcHKcssT..sLpNlD.pKTKKlIpcl+cELEEl......KKElDN..htN.sclsIpsIpsKhIhKKscNssVSEp.EsapQLcNp...........................................c..pht..s....p.p..pchp..+...thhhp...hhhh.hh..h.h..h.s.h.h.hhhh........................................................................................	0	0	69	117
+9425	PF09593	Pathogen_betaC1	Phage_C1; 	Beta-satellite pathogenicity beta C1 protein	Coggill P	anon	Pfam-B_991 (release 21.0)	Domain	Cotton leaf-curl disease - CLCuD - is of major economic importance in cotton-growing areas of the far-east. The infectious agent appears to be a single-stranded DNA molecule of approx 1350 nucleotides in length, which, when inoculated with the Begomovirus into cotton, induces symptoms typical of CLCuD. This molecule requires the Begomovirus for replication and encapsidation [1]. DNA beta encodes a single protein, betaC1. The intracellular distribution of betaC1 is consistent with the hypothesis that it has a role in transporting the DNA A of Begomovirus from the nuclear site of replication to the plasmodesmatal exit sites of the infected cell. The DNA beta-encoded protein, betaC1, is the determinant of both pathogenicity and suppression of gene silencing [3].	25.00	25.00	46.80	43.60	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.53	0.71	-4.38	36	475	2009-01-15 18:05:59	2007-05-08 16:19:52	5	1	198	0	0	438	0	116.10	44	96.96	CHANGED	TIpYsNpKGlcFlIDVRLpppppIhVpIplhST+SPsLsKpcahIPYsHsGIIsP....FDFNulEEuI+shLclMY+-Sslp-F+pEDMl-sIDIlMMccAsVl-Icls-cYcVpspssV	.............TIpasNp+GlcFh.lDV+lp.-sppIhVclclhST+..SPuLsKpcFhIPYsapsIhsP....FDFNul..E-uIpshlchhYpcupIpEh+pEDhVchlDIlMhcpssllsh-Vh-.YslspphsV.................................	0	0	0	0
+9426	PF09594	DUF2029		Protein of unknown function (DUF2029)	Coggill P	anon	Pfam-B_1780 (release 21.0)	Family	This is a putative transmembrane protein from bacteria. It is likely to be conserved between Mycobacterium species [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-12.03	0.70	-4.87	135	2105	2012-10-03 03:08:05	2007-05-08 16:20:35	5	21	708	0	676	2166	215	239.00	18	52.91	CHANGED	ah.YPPhssllhsPh.u...........hLs.....hssuhhlahhhs...lsshhhs.lthhhphh........................shhhhshh.hhlshtsl.hsshshGQhshllhshlhhshhhhh...tt.......t.h....................h.uGlhlGLusslKlh......Phlhsl..hhLh....p+c........a+uhhsu.sssssshssl..uhhhhs............sshthahp.hlhts.ptl...........htt.ssto...hsuhlut...hsh..............hhhhh...............shhs..sshshhhhhthh.........ps.sphtths...ssuh.h.......lLsSP	...................................................................................................YsPhssl.h...h.h.sh.s...............................h.ls................hsssh..h..l.h...hhhs............hhsl...h...hs...lhhh.h.ph.hsht........................................hhhhs.h.h.h.h.hh.s..h...pPl...htsh.sh....u..p..h..s.h...lhhslshhshhhht.........pp.......................p.h..............................h.uG.l.h.l.G.Lu....su..hKlh................Pslhhl......hhlh.......................s+c..........................................h..+s...hhtu....sssss.shssl......shhlhs........................................................p.s....h.p..h..ahp....hhhtt..tth........................hph.tspu........h.t.s..hhs.p.....hsh..................................................shhhh.hh.......................................shhs........hshsshhhhthh...............pp...tphht.hs.........hsuh.h.....hlh................................................................................................................................................................................	0	204	477	607
+9427	PF09595	Metaviral_G		Metaviral_G glycoprotein	Coggill P	anon	Pfam-B_922 (release 21.0)	Domain	This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated [1].	25.00	25.00	56.90	56.80	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.38	0.71	-4.65	6	400	2009-01-15 18:05:59	2007-05-08 16:31:51	5	1	2	0	0	422	0	170.10	51	88.21	CHANGED	LIGlTsLShALNIaLIIsYshpKNhocoEHpss.PPsEsSKcTshsssssPsTsPNsQpsTQ.oTEsST..sAostup.cTtsTsTPDsTsp.posD+HTT.PpuopspTopsspcKpsoRsso......+ppos.pToTtAspsssTsppoSsG+csTTTSspPcosuTTQspEpTopsss.oSsSpt	..LIGlTsLShALNIaLIIsYsh..+shocsEHpss.PPsEssKETsohshssssTpPNsQpsTQ.oTEssT..sAsStupscTEsTsTPDsTsp.posDcpTT.PppopppTspTspcKpsspsso.......+ppos.psoTtAsppssThppoSsuccsoTTSspscsusTTQsp-pTspsss.uS.st.........................	0	0	0	0
+9428	PF09596	MamL-1		MamL-1 domain	Coggill P	anon	pdb_2f8x	Domain	The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors.	21.00	21.00	22.40	35.70	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.98	0.72	-4.17	6	82	2009-01-15 18:05:59	2007-05-08 16:39:24	5	2	56	4	56	113	0	60.40	48	8.06	CHANGED	PphHSsVVERLRpRIEsCRRHHsoCEuRYppupsEphEhERccTlsLhpRslcu+uKRuAp	....P.hHSsVVERLRRRIEsCRRHHssCEsRYEpspsEphEhERpcThsLpQRsLcuKAKRuu...	0	14	19	36
+9429	PF09597	IGR		IGR protein motif	Wood V, Coggill P	anon	Manual	Domain	This domain is found in fungal proteins and contains a conserved IGR motif. Its function is unknown.	22.40	22.40	22.50	22.90	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.56	0.72	-4.06	18	185	2009-01-15 18:05:59	2007-05-08 16:50:16	5	7	159	0	138	171	1	56.80	39	30.06	CHANGED	lpsFLptIGRsssc+s-.pFEs.W....-cLFp..hsoppLK-hGl.ss+pRRYILphtc+aRpG	....................psFLshIGRsh..pp+ss.Kh..ps..W....cpLas..hsStpLK-h.GI..Ps+pR+Yl...Lcatc+aRpG.........	0	40	81	117
+9430	PF09598	Stm1_N		Stm1	Mistry J, Wood V	anon	Pfam-B_39435 (release 21.0)	Family	This region is found at the N terminal of the Stm1 protein.  Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein.  It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with CDC13 [1], and is known to associate with ribosomes and nuclear telomere cap complexes [2].	21.80	21.80	22.50	22.50	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.86	0.72	-3.28	24	195	2009-01-15 18:05:59	2007-05-09 10:35:27	5	3	137	2	126	189	0	68.20	35	20.52	CHANGED	NhaDLLGNDs............E.DsstsstsPs.+tlsKpsspstKt-............sP...PsussPs.........pup+stspsoG.NEuAhR	........N.FDLLGsDs............E.Dssphs....ssss.....+tl....sK....s.s......spstKts.............ss..p.P..sps.sPsttt...............+ss+s.ts.pssG.scsuh+...............................................	0	22	67	105
+9431	PF09599	IpaC_SipC		Salmonella-Shigella invasin protein C (IpaC_SipC)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of proteins associated with bacterial type III secretion systems, which are injection machines for virulence factors into host cell cytoplasm. Characterized members of this protein family are known to be secreted and are described as invasins, including IpaC from Shigella flexneri and SipC from Salmonella typhimurium. Members may be referred to as invasins, pathogenicity island effectors, and cell invasion proteins.	25.00	25.00	26.90	25.80	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.78	0.70	-5.42	5	167	2009-01-15 18:05:59	2007-05-09 11:34:12	5	2	152	0	6	107	0	338.40	53	86.65	CHANGED	+ssspuLhps-uAhushs.....................AtspslLsohLsDctpsssLspslphhsuspls+lssh....VQ+cLcpcuAclssGpshDISu................hSocAsuLlhu.lssLMusLspADs+LuoKLSLlSFDATKoAAuShlREGhAsLSSSIsGuAsQluITGVGAKpphsGLssc+GALK+NLsstscLssEu+slpLsLNpQNsssLuA...DtlppltlK+ssu-usKplsc.p...................lssuNcplSsEHcusLupcstulpc+I-hcppsa-psplKAQppQppGDtlMcsSssAGNIuuuSGpYAustEcuEQpISQuuu+sApoASs-o+EuS++ocplIQElL+sl-SIsQS+o	...................................................................................+.suchuLu.sLuA.APsV....................LspsssslToaLp.sshQsochsQ-lNtLAsslTsKss-s....VQTpL+EppAEV......GchhDISu................MSSsAVALLuA.AssLMhoLNQA....DoKLSGKLSLVSFDAAKosAuSMhREGhsuLSGSISQSALQLGITGVGAKLcaKGLpsERGALK+NuAKlcKLoTEu+uIKssLNGQNol+LGA..sDuLKolshK+T...GsDuTKsLs-soh................htIKcSNKplSsE...HQAlLSKRlE.SlE.ScI.cL.EQsTMDhT+l-ARKMQMTGDLIM+sSsolGsIAGASGQYAAsQERSEQQISQsNNRVASTASDEARESSRKSTSLIQEMLKoMESINQSKA................	0	2	2	4
+9432	PF09600	Cyd_oper_YbgE		Cyd operon protein YbgE (Cyd_oper_YbgE)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a small protein of unknown function, about 100 amino acids in length, essentially always found in an operon with CydAB, subunits of the cytochrome d terminal oxidase. It appears to be an integral membrane protein. It is found so far only in the Proteobacteria.	22.00	22.00	27.30	26.90	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.80	0.72	-3.82	21	679	2009-01-15 18:05:59	2007-05-09 11:41:23	5	1	674	0	64	249	4	80.50	64	85.54	CHANGED	..LR........uLSllLAlhlsuhlhWsPstaAsphuuhsshhu.hllWAlCuuhlaGVGFcP+phlWphlF.uPhhuhsILhhslh....aah	.........................PLRALSFVMAllLAGCMFWDPSRFAA+TSpLEIWHGLLLMWAVCAGlIHGVGFRPppVlWQGI.F.CPLLADIVLIlGLIFFF.h....................	0	3	22	44
+9433	PF09601	DUF2459	Chp_urease_rgn;	Protein of unknown function (DUF2459)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This conserved hypothetical protein of unknown function is found in several Proteobacteria. Its function is unknown and its genome context is not well-conserved. It is found amid urease genes in at least one species.	21.80	21.80	23.40	24.10	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.06	0.71	-4.57	33	265	2009-01-15 18:05:59	2007-05-09 11:44:24	5	1	262	0	60	200	49	167.20	41	75.35	CHANGED	IhllssslHTDlllPhss....hhthhthhsssslshstsss.p.alshGWGs+sFYhsossas-lsstsslcAl.ssss..oVl+Vsshsshs......ssssltplslupspappLhshlpsoFttstsuts..l.ssuasss-tFatApGcashhpTCNsWoussL+sAGlchuhWs.Phshul	............................IYllSpGhHT.sIlhPscss.............shshs..plcpc.as.pt...p.ahplGWGD+uFYts....p-losuhsLpAhFhsou..uVhHlssaushPc..........suu-l+sL...hLpssQhssLhcalucSFsRDtpGs.lIsl..c...........tG.hhucspFYsAsGRYulLsTCNpWTAcuLcuAGLshss.h.Lstu.s.........	0	19	41	49
+9434	PF09602	PhaP_Bmeg		Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a protein found in polyhydroxyalkanoic acid (PHA) gene regions and incorporated into PHA inclusions in Bacillus cereus and Bacillus megaterium. The role of the protein may include amino acid storage.	22.20	22.20	22.60	22.50	22.00	20.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.21	0.71	-4.42	2	94	2009-01-15 18:05:59	2007-05-09 13:53:14	5	3	92	0	6	35	1	162.60	80	76.60	CHANGED	MpTh.Y-.llDAhWcpWopuLp.hususKQlEQhTLcsLcQQQ-h...lTpuV-pLptp.pQapAphps..pchVcpL...sGNulsDphpEWpp+h+Eh.s+hQpLhhs.oKoShSllpQsptQacpsspQhlEpQphpRpEhQ+..-ualEphK.hQhphApphEp	...........................METKPYE.LVDAFWKNWSQSLSLFSSAGKQLEQLTLET.LKQQQDALHKLTSGVDELEKELQQF.......TAQFNNQYTDYVKQL....TGNSLNDQIN..EWQ-KWKELSAHM..pQLTVSPTKTSLSILTQTSGQFEETTKQFIEQQQLQREEAQKQLEGFLEEFKoKQLELAKKFEE......................	1	0	2	3
+9435	PF09603	Fib_succ_major		Fibrobacter succinogenes major domain (Fib_succ_major)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This domain of about 175 to 200 amino acids is found, in from one to five copies, in over 50 proteins in Fibrobacter succinogenes S85, an obligate anaerobe of the rumen. Many members of this family have an apparent lipoprotein signal sequence. Conserved cysteine residues, suggestive of disulfide bond formation, are also consistent with an extracytoplasmic location for this domain. This domain can also be found in small numbers of proteins in Chlorobium tepidum and Bacteroides thetaiotaomicron.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.59	0.71	-3.79	40	375	2009-01-15 18:05:59	2007-05-09 14:02:06	5	24	93	0	169	369	212	179.60	19	39.68	CHANGED	VpIGsQhWMAcNLcsscYRNG-.sl.psts.ttW.....shssuAaCaYsscspssph.........YG+LYNWaAV.........sDs..................R.GLAPpGWHlPoD.sEW.ptLtshl.............G...GcstuGutLKu..h.....stWttss.sss........sspsGFsA........lP.uG.hRsssGsF.hhtGphuhaWooocss....stpAasRplshs....s.sslt+spss..+p...tGaSVRClK	..................................................................................................hstphWhspNLp...................................................ssshs..........pt..psttt.............................hG.hhYsatus....................ss................................................................p.slsPpGW.+lPop.sEa.ppL.hphh.................................................s............p..tsupt.lps...............staht.t.....t..........................tsthGFss...........................hs..sG...ht........t...........s..........s.....s............t.......h.......tt..sphshaWo.s..s.pts..........s.t.sh..h.h.h.ht......t..t...h..ps.ths........pt......uhulRCl+.....................................................................................	1	120	132	160
+9436	PF09604	Potass_KdpF		F subunit of K+-transporting ATPase (Potass_KdpF)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a very small integral membrane peptide KdpF, a subunit of the K(+)-translocating Kdp complex. It is found upstream of the KdpA subunit (IPR004623). Because of its very small size and highly hydrophobic character, it is sometimes missed in genome annotation.	19.20	19.20	19.40	19.50	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.52	0.72	-6.83	0.72	-4.02	40	728	2009-01-15 18:05:59	2007-05-09 14:09:44	5	1	704	0	103	314	5	25.00	44	58.04	CHANGED	hhluslluluLhl...YLhhALlcPE+F	.........llulllshhLls...YLlYALlpsEcF..	0	34	62	84
+9437	PF09605	Trep_Strep		Hypothetical bacterial integral membrane protein (Trep_Strep)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of strongly hydrophobic proteins about 190 amino acids in length with a strongly basic motif near the C-terminus. It is found in rather few species, but in paralogous families of 12 members in the oral pathogenic spirochaete Treponema denticola and 2 in Streptococcus pneumoniae R6.	26.50	26.50	27.50	27.00	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.34	0.71	-4.62	23	1171	2009-09-11 16:54:32	2007-05-09 14:23:32	5	2	634	0	118	730	19	180.40	28	94.33	CHANGED	ps+DLlsIGlFuAlYFlh.hhlsshluhhsPhhh..hhtPslsulluGslaMLhls.+VtKhGslolhullhullhhhsGph.hhhhlssllsullA-llt.phu...pY+shptshluYslFuhhhs..G.shlPhahhh-sYh.tshhppGhupsYl-shhthhss.hhhhlhllssllsuhlGuhlGp+lLKKHFcK	................................hKDllshGlFsllY.Flh.hhls.s.h.l..u..h.l.....s.hhh..........hhhPshsulluGslahlhhs.KVt+hGsl.hlhGllhulh.h.h.hs.Gas..hsshlsull.s.ullA.-llt..p.hG...pYc.s...h.p.t.sh.luaslFu..h.shs..G.shl..hal.s.tctYh.tph.h.tp.uh.up-Ylstlh.th.h.ss...hhhhlhlh.sshlsullGuhlGptllKKaFpK....................................	0	64	86	105
+9438	PF09606	Med15	ARC105; ARC105_Med_act; 	ARC105 or Med15 subunit of Mediator complex non-fungal	Coggill P	anon	pdb_2gut	Domain	The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development [1].	26.20	26.20	26.40	26.40	25.90	25.60	hmmbuild  -o /dev/null HMM SEED	799	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.78	0.70	-13.71	0.70	-6.34	7	273	2009-09-11 06:41:54	2007-05-09 14:50:32	5	17	89	1	140	249	1	349.30	26	82.33	CHANGED	QpVVspIc-AhppsGhsp.....oKsut-MEsHVFtKA+o+DEYLuhVARLIlHhR-hppKppQsp.s.....................DPhNALQsLsutss.sst....shshGP.tP.GtphGG.Gshoshhpsh................psQ...u..shu.PpthstVuths.usQhss.h.........tt.pt...ttttuthtt.t.p.tQt...ttt.P.tMhtshhs.....t..tttt.....ttt.t.ts.pQ.p.h...t.Q.p......Q......p.phpQ.ps.tputsQh.p..tsput.psQphttu.sQ..shpQt.sttp.p.s.hthh.tQhpQh.........stG.ttshupst..Psp.hss.s..Qt...hs.............hhs.tt.t.h............Q.psptQtQpttsp..stt...........................................tQ.s...tstpuuph.u.t....................................................t.....ptsshsshsssthsptp..MMSussPs........pspssQtM..sPQPp.PpPstPsups..sp.ssus.hPSP.uhhPSPSPQ.uQsssstRs.tp......SPG.sL.......NTPGp..sus.SPhssp..EEp.Yh-Kh+pLoKYIEP..L+RMIsKh-ps.tch.cchuKMKpLL-ILosPopRsPLcTL.KCEhALp.........sphus.p.sP..........hspPLl-AV.uNlpSPlhNHoL.R...TFtPshpAlaGssIts.sssu+p.Rlp.D-........pQpIPplLQGElARL-sKFhVsLDPstpuss.tsl+LICpLDDKpLPsVPPlplolPt-YP.pSPphp.tpppYsAsPFL.p.Vp+shhu+lspLPthaSLotLLsTWt.uVRQAC......................hLuh	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hst.....................................................................................................................................................................................................................................	0	51	60	103
+9439	PF09607	BrkDBD		Brinker DNA-binding domain	Coggill P	anon	pdb_2glo	Domain	This DNA-binding domain is the first approx. 100 residues of the N-terminal end of Brinker. The structure of this domain in complex with DNA consists of four alpha-helices that contain a helix-turn-helix DNA recognition motif specific for GC-rich DNA. The Brinker nuclear repressor is a major element of the Drosophila Decapentaplegic morphogen signalling pathway [1].	23.40	23.40	23.40	23.50	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.81	0.72	-4.40	3	116	2012-10-04 14:01:12	2007-05-09 14:53:10	5	11	65	1	88	108	0	53.40	40	11.82	CHANGED	GSRRuaouuFKL..QVlESacsDNsC+Gs.RAsA+KYNIpRKpVcKWLQsEsQLQsucAp	....................RRoasssFKL..pVl.-hA.c..psssCp.....sA+cFsl..pc..+pVccWpchcspLpst...................	0	25	41	71
+9440	PF09608	Alph_Pro_TM		Putative transmembrane protein (Alph_Pro_TM)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of predicted transmembrane proteins of about 270 amino acids. Members are found, so far, only among the Alphaproteobacteria and only once in each genome.	20.40	20.40	20.50	21.30	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.40	0.70	-4.84	49	249	2009-01-15 18:05:59	2007-05-09 15:58:14	5	2	244	0	90	221	746	229.60	36	87.83	CHANGED	EplVhuLSpccVsIossFsGu-lllFGAlcptssh.tt..shDllVslpGPspslslR+K-RhhGIWlNs-uhphcssPoFYAVAoo+Plcclssts.pttchplGls.........hs...................ttssss.sssss..pFpcALlRl+pppGLY........ppptsuVplhppsLFRsslpLPAsls.GsYpsclaLhRsGplluptpsslpVpKsGhEpalashA+ppshlYGLhulslAlhsGWhAuslFRth	...................Epl.lulSscpluITusFsGs-lhlFGAlcpts.sh........tt..thDllVslp.G.Ps.psl.s.VR+.K-RhhG.l.WlNssShpFtslPshYulAooRslpcls.s..tp.shp...phplGlpph..........Ls......................ss.ss.ss...sssh.pFtsuLh+l+pppGLY.........ppc.uuVph....hsp.....oLFR....AslsLPAslPsGpaps+shLhRsG.thlsptssslclhKsGlEphlashA+ppsllYGLhulhlAlhsGWhuuhlFR+....................	0	29	59	70
+9441	PF09609	Cas_GSU0054		CRISPR-associated protein, GSU0054 family (Cas_GSU0054)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a rare CRISPR-associated protein. So far, members are found in Geobacter sulfurreducens and in two unpublished genomes: Gemmata obscuriglobus and Actinomyces naeslundii. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	20.80	20.80	21.90	21.80	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.62	0.70	-5.68	4	90	2009-01-15 18:05:59	2007-05-09 16:03:54	5	2	55	0	36	91	7	277.10	14	76.09	CHANGED	hhulohphhsG+acuss..........sD.usP...EWPPuPhRlFpAlVAoht.chs......E-h-sLpaLpu...Pslhthssshsu........psshphVstsasRG.pchasGsus.hpc......pslslPcsssVthlWc.s-ss-tplA.ls+lstplsahGRspShshspVV.sGul..........hs.cWlsct-s.....GslslRsPhsG.....pLp-Lps+aEshhshh.hGsh..s.PhssYs.hsphlu.-.s.ps..s..h.ch.shG.+tssssphtLDltshs..T-uLRRAslup........hcssplsuhlpGH....GD-tp......HsAYLslssluc+tAcG+l.slGshhPs.loth-......GhhGs-.s..huLh+s+pLtclcLc.ss....VuhhuLps....pths..tuS+oWsoVTPhhLsRaP............................s++lp..................ssullttSlspsGhP.Pttlpslss.tlsGshR....hcRYsshcshpphP....hHs+Isa......Pp.lcGPlhlGusRaaGhGLFsP	.........................................................h...............................t.....E..PtP.Rlhtuhhush....th.....................t.........hl....t......................h.....................................................................................................................................................................h.h......................h...hh..h.........s.h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	28	32	32
+9442	PF09610	Myco_arth_vir_N		Mycoplasma virulence signal region (Myco_arth_vir_N)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents the N-terminal region of a family of large, virulence-associated proteins in Mycoplasma arthritidis and smaller proteins in Mycoplasma capricolum. It includes a probable signal sequence or signal anchor, which, in most instances, has four consecutive Lys residues before the hydrophobic stretch.	20.40	20.40	20.50	24.10	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.55	0.72	-4.00	6	43	2009-01-15 18:05:59	2007-05-09 16:05:19	5	1	12	0	15	38	0	32.70	60	2.93	CHANGED	MYFLKKKKNKILshALVASLATSLSFGSVIYYS	.MaFlKKKKNKILshALlASLssSlSFGSVIYYS...	0	4	15	15
+9443	PF09611	Cas_Csy1		CRISPR-associated protein (Cas_Csy1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2465 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy1, for CRISPR/Cas Subtype Ypest protein 1.	20.20	20.20	20.50	20.30	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.31	0.70	-5.52	18	182	2009-01-15 18:05:59	2007-05-10 09:29:29	5	1	173	0	41	149	8	345.90	35	83.41	CHANGED	spYphpsWLsD.AA+RAGQIpLVTHshKasHsDA+GSslashs......tptsspaLuo..s.sphAhDslGNAAALDVhKhLplph.-.Gc.oLLspLppsDssALssLucsscQ....hcpWhsuFtslhssc..phoSHpLAKQlYFPl...........tsspYHLLuPLFuSoLAatlap+lppsRFu-psKtARpA++cpcaHspshhpYPsLAsQphGGTKPQNIStLNSpRGGcsaLLsShPPpWc.spp+sPhphcSlFp.psthpspspstlppLppaLtssp...........sNhclRppRs.phlsplIDpLlphsuplQph...sGWSspspp..pLtcspQLWLDPhRs..........sDpsFppERcpsD.W.pplupcFupWLNppLpp....ppl.lG-sEt+cWpp	..............................................cYphcsWLs.c.AA.p.....R.AtQlphsTHssKhtHsD...u...Ku..sslh.....h.s.......phspshlso...slsph.......s.hD.s.h.GN.AAA.....LD.lsKhLphph.-...Gp...oLlstlpp.s-.phhphhu....p...spp............hp.pahpuFtphhpsp...p.soHclsKQlYFPl...........tsspYHLLsPLasSSLspthap+lsp.sRFS-psKpuRps++pschp.pshhph.slAs.phGG.........TKPQNIShL.NS.pGG+saLLsShPPpap..st..+.P.p.cohF..p..sththtspshltphpphltsst................NshclRstRt.phlspllDhlhthsttlQph...sGWSpp.....pL.ttp..plWLDPhRs...............s-ttFpp.c.cpppD.W.pplspcFutWL....NttLpc.......pphshGssEhpcWp.t...........................................	1	10	25	33
+9444	PF09612	HtrL_YibB		Bacterial protein of unknown function (HtrL_YibB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The protein from this rare, uncharacterized protein family is designated HtrL or YibB in E. coli, where its gene is found in a region of LPS core biosynthesis genes [1]. Homologues are found in Shigella flexneri, Campylobacter jejuni, and Caenorhabditis elegans only. The htrL gene may represent an insertion to the LPS core biosynthesis region, rather than an LPS biosynthetic protein.	23.60	23.60	23.80	24.80	22.20	23.50	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.82	0.70	-5.14	3	269	2009-01-15 18:05:59	2007-05-10 09:39:14	5	1	240	0	15	100	74	249.20	59	89.51	CHANGED	M-spTTIITAFFDIGR+Da.......KclsRSNDKYaSYFEFLAuLKNcMIIYTsEslKc+IcuIRscasLE-KTThIIlc-Ip-hccpIYKRII-IppDcoF+Na...lp.RphcNsEshSPcYsYLMhLKuaFVsDAIsRGLT-TN.lAWIDFGFNHGGNVFsshcpFDF.a...sshDENKINLFoIKK....sDQQslF-IhhuhEsaIMGGlIlusS+pWccFY+hsLEShKIhsShGIlDDDQlIhLaC..sYRRNs..sYNhIt+upWFDuLpHFpspslGuKLpI	................McsShTIlTAaFDIGRGDWsupcGF.ccLsRSsDsYFSYFE+LAuLENcMIIFTSPDLKsRVEAIRN.....GKPTT..VIVIDIK...Kp.....h.+a.I+....s.+.....Ic.K..IQ.KDESFTN+...L.-P+plK.NPEYWSPEYVLVsNLKsYFVsK.A.IphG.L...VK....Ts..LVAWIDFGYCR+s.N.V.TpGlKhWDFPF.......DEsKMHLF.TI....KKGLsloSpQplFDhM.IGNHVYIIGGAIVGSQHKWKEFYKLVLESQKITLNNNIVDDDQGIFVMC..YYKRsDLFN.LNY.LG.R.GKWFDLFRCFRSNTLGAKMQA..........................	0	8	9	15
+9445	PF09613	HrpB1_HrpK		Bacterial type III secretion protein (HrpB1_HrpK)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family of proteins is encoded by genes found within type III secretion operons in a limited range of species including Xanthomonas, Ralstonia and Burkholderia.	26.90	26.90	27.10	27.80	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.86	0.71	-4.74	8	155	2009-01-15 18:05:59	2007-05-10 09:40:55	5	1	96	0	27	103	0	158.00	31	94.89	CHANGED	shhpCssplluGLl-llssALpts......chtDhptlLpALRlLRPchsth-hhDGWLplsRtpWs-AtRlLR-l...-ssssshshu+ALhAhCLpuhpDssW+ttApclLtpssss-ulsLV+sLhuppshhpA.t....................ssssuu-Asussspu............s..tp.pahRl	..............h.pCstthlsGLl-shssALpts......c.tDhptlLsALRVLcPphssh-hh-uhLplt+tpas-AhRlL+c.l...ssss...sptshu+ALhAhCL.....pshsDssW+th........AsplLtsss..sssuhsLV+uL.stpshh.h......................................s.htsp..hts..s.............................................................	0	5	11	16
+9446	PF09614	Cas_Csy2		CRISPR-associated protein (Cas_Csy2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.	25.00	25.00	32.40	29.70	19.10	21.30	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.62	0.70	-5.21	25	219	2009-01-15 18:05:59	2007-05-10 09:58:56	5	2	202	0	47	169	10	266.80	33	80.18	CHANGED	LlLP+l+VpNANAlSSPLTaGFPulTAFhGas.HALpRKLsspt...slplpusuVlsHcaplpshps...hs......psFsLTRNPL......sK...sGso........uuhlEEGRhHLslSLllpssuppt............sppptpthhppltpll.tshRlAGGoll.......phtpschhphs........tpchcphh++LlPGFsLlsRp-LLssthppLpps....................stsphlDAaL-hus.lpapshsspssp............Wp...+.....p.sGWlVPlslGYpul.SPh..atsGplpssRDspsPapFsEolaulGEWlsPHRl.p...........slsplLWpacsc..ppsl.....YhCp	...........lll.cl+lpsANAlSu.lThGFPuhTsahGhs.HALpR+Ltp...pt.....sl..plpGsulhsHphplpsapss..hs..........hsFthTRN...PL......pK........pups............suh.EEu+hHLslSLllEhpsp.t.............ptttpthhpplpphh..ptRlAGGolh............shtpsplhph..............phcclhh.pLhPGasLh-RpphLscthpphppt............................sp.p.LDAhL-hss.lchps..stsss..................Wth..h.......tGaLVPlssGYpuI.SPl..htsGpsppsRss....phP...apFsEslaulGcWhh.a+l.p...................................slpphhWpYchp...pp.h.....Yhh............................................	0	9	25	35
+9447	PF09615	Cas_Csy3		CRISPR-associated protein (Cas_Csy3)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	25.00	25.00	29.50	29.50	22.50	24.90	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.91	0.70	-5.34	23	219	2009-09-11 10:34:39	2007-05-10 10:02:20	5	1	207	0	48	165	10	318.40	48	97.09	CHANGED	csASVLAFERKLssSDAlhauusW-s+s...pasPlplpEKuVRGT...ISNRLK.stspDPAKL-A-l..ppsNLQpVDVAsLPs-sDTL........KlpFTLRVLushupPSsCNsstYpppLtpslssYhpcpGFsELAcRYApNLANGRFLWRNRlGAEslplpVs....spstpsas.FDAhpasLRsF...spsspplspLuphItpGLuu.ssaslLcVsAalclGtGQ.EVaPSQELlLDc...s..cupKSKhLYpV....s..........slAAhHSQKIGNALRTIDTWYPcss-....hGPIAVEPYGuVTspGpAYRQPK.pKtDFYTLL...DsWlh+schP......slE.pQHYVMAlLIRGGVF.GE	..........sASVLAFERKLssSDAhhaussW.ps.pp...phpPlplpEKuVRGT...................ISNRLKs..shss....DPsKL.DAEl.....pKuNLQpVDsAsLs..-sDTL.........cspFTL+VLushupPusC........ND..pYptpLtsslpsYlpppGFpELApRYApNlANGRFLWRNRlGAEpIpVpVs...........tspppsap..F.supphuL+pF....spsspplppLAphIppGLuu.psas.......hLpVpAhl+lGtGQ..EVaPSQELVLDp.......pupKSKlLYpl.....s......................shAuhHSQKIGNAlRTIDTWYP-ssp....hsPIAVEPYGuVTshGpAaRpPK.pKhDFYTLh........DsWlh+sphP......sl.E.pQHYVMAsLIRGGVFG............	0	10	25	36
+9449	PF09617	Cas_GSU0053		CRISPR-associated protein GSU0053 (Cas_GSU0053)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	25.00	25.00	29.60	25.20	19.70	18.30	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.29	0.71	-4.47	4	71	2009-01-15 18:05:59	2007-05-10 10:12:02	5	2	66	0	28	72	5	173.40	26	46.68	CHANGED	uulllcAsLpPVpGts.+lhPsTF.....uussYph..thsDG...ssslllDSVsS.ANRlE..Lhshc.st..lV......P.Ipspls..stploslEhsHRhsDAhl..RsS.lstsp..spsltptLpssps+ss......csLhthtPpoLlaGsWDS...cpsptsKluR.luuhI.uYsVcsl....ppuu	....................................pLp.PssG...tltPssa...ssh......ss.usYsh......ph.....s.cG...............hpslLlDSspStANRhEthlhp.t..h..csup.....hl..........................thPhlpV..ph.p................sst..p.h..o.s.....lptsHRhsDual...Rsup.h...st.t...........h......pcpsh.hp.shp.s.s.s.psh.................psl.hchsPsuLlaGs.WcS....tpt..s...sph+lsRslsupI.u..........s............................	0	17	24	25
+9450	PF09618	Cas_Csy4		CRISPR-associated protein (Cas_Csy4)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.	25.00	25.00	25.10	25.10	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.26	0.71	-4.47	32	230	2009-01-15 18:05:59	2007-05-10 10:15:38	5	2	218	7	52	183	6	181.10	33	97.59	CHANGED	Yl-IplLPDsEhstshLhstlaspLHtsLsp....hspscIGlSFPpast............sLGspLRlau.sppsLppLptpsWlpshpD..YsplusltsV.Psssp.apshpRhpspu......shpRhh+Rhh+Rt....thstEpsptthspphp.pph..shPalplcStS.......ssQ.pFhLFIc..tphtspsssGtFsuYGLSss.......uTVPaF	......................Yl-IpllP...c.s...EhstthLhutlaspLHpsLst.............ptpscI..G.VSFPphst..............sLGs.pLRlau.sppsLppLptp.sWh..p.s.Lp.D..Ysplo.pltsV..Pp.p.sp..apshpRsQsKu......stpRhh+Rthp+t..................tlsp-psttch.pptp.ppt...............shPalpLcStS........opQ.pFhLaIc..tphts..p.s..spGpFsuYGLSps.......uTVPaF...........	0	12	28	39
+9451	PF09619	YscW		Type III secretion system lipoprotein chaperone (YscW)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is encoded within type III secretion operons. The protein has been characterised as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerisation and localisation of YscC.	21.50	21.50	21.50	21.60	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.23	0.72	-4.33	11	875	2009-01-15 18:05:59	2007-05-10 10:43:35	5	7	808	3	107	364	9	110.00	50	60.76	CHANGED	s.tst.u.spVsGsVplpp..uLPhsAslpVTl....Lusssu+lLs.tssRhEssthPhpFsL.hNPspl.scucIhLpAtlphss+hsl.sss.QpVhs..ssschclpLlP	.....................shppssVSGTVhlRp+.lALPP.DA..VLTVTLSD..sSLA.D.AP.S..+..V..LA.Q+...u.l.R.T.E.GK...Qu.P.FsFsLPFNPu-lp...PNARll.LSAAIo.VssKLlFITD.T.lps.VIs..pG.G.sc.uDLpLVP.............................	0	15	35	72
+9452	PF09620	Cas_csx3		CRISPR-associated protein (Cas_csx3)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is encoded in CRISPR-associated (cas) gene clusters, near CRISPR repeats, in the genomes of several different thermophiles: Archaeoglobus fulgidus (archaeal), Aquifex aeolicus (Aquificae), Dictyoglomus thermophilum (Dictyoglomi), and a thermophilic Synechococcus (Cyanobacteria). It is not yet assigned to a specific CRISPR/cas subtype (hence the x designation csx3).	20.90	20.90	21.90	21.20	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.55	0.72	-4.18	7	37	2009-01-15 18:05:59	2007-05-10 11:28:15	5	3	34	0	14	37	1	78.50	31	36.24	CHANGED	chcLpcs...ltP-DLtplplPshlcsptG...VVlSGRuPIWLYuaLlHchH...TsalAsaDPRL..GAVVVuSHo.phR.GpVI.h	....................................ts...lp.ptltthp..lPt.ls.ptG....lV..loG+uPIWLYshLlHth.H...ssalAsa.DP+l..Gu.VVltoH.s.th.psGpll......	0	8	12	13
+9453	PF09621	LcrR		Type III secretion system regulator (LcrR)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family of proteins are encoded within type III secretion operons and have been characterised in Yersinia as a regulator of the Low-Calcium Response (LCR).	21.20	21.20	24.20	23.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.69	0.71	-4.90	7	286	2009-01-15 18:05:59	2007-05-10 11:50:46	5	1	274	0	15	74	0	113.30	36	83.16	CHANGED	hp-PLlPWhht+GltVpPahhpposI.LGath.hcGhcLAWRV-..ptRlWIVhl+RsptptGLuNPFAALYLLApAshslLGssahLYGNVsVLtuSsLsupRLA+FYpRWsGAS.E.psGWF.Ltst+Vhoh+sh+KRQp	.........p.l.paLcp+GhhspstaLstoAIhlG.ph.hssaplsYRl-..tpElIICpFcRhpsp....t..G.LtsPh.sL.h.hLhpthh.hhs......hl.u.......htss....t.pc..h..ah.ph.s....-..........Wa.h................sp.............................................................................	0	3	6	9
+9454	PF09622	DUF2391	CHP02587; 	Putative integral membrane protein (DUF2391)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is found in Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus in a conserved two-gene neighbourhood. Proteins containing this entry appear to span the membrane seven times.	20.60	20.60	20.60	20.70	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.72	0.70	-5.24	9	115	2009-09-10 18:53:12	2007-05-10 12:00:33	5	1	112	0	52	100	14	184.30	24	90.50	CHANGED	sslsRGhAGAhLFulPhLhTMEhW.lGhalcPhRLhLlLslshslLhlLs+ttGFR+op...shc-sltDul.AhulGhlsuuhlLhlhthlssshuhcEhlGKlslpuVPsoIGshLuRs.Lttcus-sppt..t..............pstsuhhu-LhhhhlGAlFluhNlAPT-ElhlluhthoPaahlhllLASLhI.ashVatspFpsp+phtpppGhapt.lp.TlsuYllulhluhhhLWhFpRhs.ssuhpphlptslVLGhPAoIGuAAuRLll	........................t.....shsGuhh.hulPh.ho.EsWtlG..h.....p..Lh...hl..h.lsh.hlhh....hsh.tsFppph.........ph......h..l..hchhhAhhlu......hl...ssshlLhhhshls.h..s.......lt+lhl.shPhohGAhls.................................................p....hhGuhhhshsh..st-h..lu..h.....hhhh.h.hhh.h.hh.....................................h....h.s.......h......................................................................................................................	0	12	29	45
+9455	PF09623	Cas_NE0113		CRISPR-associated protein NE0113 (Cas_NE0113)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this minor CRISPR-associated (Cas) protein family are encoded in cas gene clusters in Vibrio vulnificus YJ016, Nitrosomonas europaea ATCC 19718, Mannheimia succiniciproducens MBEL55E, and Verrucomicrobium spinosum.	21.20	21.20	21.80	21.60	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.50	0.70	-4.89	17	107	2012-10-11 20:44:46	2007-05-10 12:53:01	5	5	94	0	44	103	11	188.90	25	58.63	CHANGED	hKplLlushGhoPQVlTETL.uLhppup......hss-lhll..oTpps+sphthsLL.............pphhp-a.......thpastsslpl..l.sspst.lsDIpotp-stthhshIhphltpLpps.s.tplHlSlAGGRKsMuhhhuhAhpLauc.pDpL.HlhVss.hE......pFhh.stpsthlplpstps.....st..h.VpLsplPalphpp.lsstlhp..uths.spsltphppt.s.	.........................................pplLlushGhoPQ....llTETlhsLhppst........hssElhll..oTps.stsph..thpLl...................tphhp-h.......thphppp...lpl.....hhs.ppst.lsDIcot....cDspthtchIhphltphptp.t..tlahsluGGRKsMuhhhshAhphht..tDtl.Hlh......st................................................h..hs..................................tt.............................................................	0	21	34	42
+9456	PF09624	DUF2393	CHP02588; 	Protein of unknown function (DUF2393)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The function of this protein is unknown. It is always found as part of a two-gene operon with IPR013416, a protein that appears to span the membrane seven times. It has so far been found in the bacteria Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus.	24.60	24.60	25.00	26.40	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.80	0.71	-4.68	40	338	2009-01-15 18:05:59	2007-05-10 12:55:27	5	1	213	0	42	168	8	149.40	34	87.04	CHANGED	hhhhhhhhlslhhcpp.....hhhhhlhhshlhhhh.hshh.........hhhhl.cpts+psplslspscp.lp..hspshhls..hslpNpuphsh................ppCplpscl.hp......sssshhpphthp.ts...ahpp...................ph.ltp..Lphscspph....phh...hs...t.sh...tshslph.pupCh	.............................................................h.LhshllhLplh.+ch.....Ahl.hhhhsIlhshL.lYhh...........hhpll.pppspsphoplsps+...lp....spulIls..hplpNhoKhsh................+cChlhhcIhspp....sssslhp-hph+.h.....appp....................ohEIh-..L.sNssp.h....Rhu...hs.....sh...NNhphhh.s.cCh.............................	0	11	34	41
+9457	PF09625	VP9		VP9 protein	Coggill P	anon	pdb_2gj2	Domain	VP9 is a protein containing a ferredoxin fold. Two dimers come together to form one asymmetric unit which possesses a DNA recognition fold and specific metal binding sites possibly for zinc. It is postulated that being a non-structural protein VP9 is involved in the transcriptional regulation of the White spot syndrome virus, WSSV, from which it comes. WSSV is the major viral pathogen in shrimp aquaculture [1]. VP9 is found N-terminal to the Pfam:PF07056 domain.	20.50	20.50	20.60	22.90	20.20	17.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.51	0.72	-4.17	6	19	2009-01-15 18:05:59	2007-05-10 13:38:38	5	2	2	7	0	15	0	77.60	41	19.98	CHANGED	Lpl+suFhlsG-c.s-+YEcVhh.oFcuV-.....olRKSELcDssaIVpLK-scpl+lpsGlccLRpLTGDsoLpIp.hlosshP	..LphcuuFhhhG-c.sc+YEcVht.oF-uV-.....olR+SELc-ssaIVpLKcscphphpsGlccLRpLTGDsoLpIp.hlossh........................	0	0	0	0
+9458	PF09626	DHC		Dihaem cytochrome c	Coggill P	anon	pdb_2fwt	Family	Dihaem cytochrome c (DHC) is a soluble c-type cytochrome that folds into two distinct domains, each binding a single haem group and connected by a small linker region. Despite little sequence similarity, the N-terminal domain (residues 12-75) is a class I type cytochrome c, that binds one of the haems, but the domain surrounding the other haem is structurally unique. DHC binds electrostatically to an oxygen-binding protein, sphaeroides haem protein (SHP), as a component of a conserved electron transfer pathway.  DHC acts as the physiological electron donor for SHP during phototrophic growth [1]. In certain species DHC is found upstream of Pfam:PF01292.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.98	0.71	-3.44	35	196	2009-01-15 18:05:59	2007-05-10 14:12:42	5	5	163	2	75	205	20	107.70	32	55.86	CHANGED	YhccCuuCHhAaPPtlLPupSWpplhssLspHFGssAs.LsssspttltsYLpspuuststs.............ssssPh.RITcs.aFpcpH..pcls.thhp.pspltohusCsuCHss.AcpGsF	....YtppCu.uCHhAaPPslLPupoWptlh..s..s..LppHaGssAs...Ls.sssptpItsYLtspAuptst.......................sssss.+Iocs.aFhcpH....scls.......thhp...spltohusCsuCHstAppG.a.......................	0	19	56	66
+9459	PF09627	PrgU		PrgU-like protein	Coggill P	anon	pdb_2gmq	Domain	This hypothetical protein of 125 residues is expressed in bacteria but is thought to be plasmid in origin. It forms a six beta-strand barrel with three accompanying alpha helices and is probably a homo-dimer in the cell. It may be involved in pheromone-inducible conjugation [1].	25.00	25.00	77.10	77.10	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.52	0.71	-4.53	2	54	2009-01-15 18:05:59	2007-05-10 14:19:04	5	1	40	2	2	31	0	100.60	89	88.98	CHANGED	MKElAIQEK-lshpWpG.pG+Llhl+lKps+shEhhhNpQlT.ENIpEIsslpllKNGKoLsLcV.sE+Shash.p.uphpVPhFaIcT.IpRtsac-hF..............Gpp..lKt	MKEIAIQEKDLTLQWRGNTGKLVKVRLKNTRAMEMWYNKQITEENIQEITTLNIIKNGKSLALEVYPEKSIYVKPNLGRINVPVFFIKTPINRGlFEEIF......................GETLK.......	0	2	2	2
+9460	PF09628	YvfG	Yvfg; 	YvfG protein	Coggill P	anon	pdb_2gsv	Domain	Yvfg is a hypothetical protein of 71 residues expressed in some bacteria. The monomer consists of two parallel alpha helices, and the protein crystallises as a homo-dimer.	25.00	25.00	123.50	123.30	22.40	18.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.22	0.72	-3.83	2	24	2009-01-15 18:05:59	2007-05-10 14:21:45	5	1	24	4	6	13	1	67.00	88	93.33	CHANGED	pLFos.hhhpNh+pahp.Npu..sKIpAhNuYY+sVsuolltDplsKNAsllhRhpHL-EAYpKVtpt	ELFSVPYFIENhKQHIEMN.s.EDKIHAMNSYYRSVVSTLVQDQLTKNAVVLKRIQHLDEAYNKVKRG	0	2	3	4
+9461	PF09629	YorP		YorP protein	Coggill P	anon	pdb_2heq	Domain	YorP is a 71 residue protein found in bacteria. As it is also found in a bacteriophage it might be of viral origin. The structure is of an alpha helix between two of five beta strands. The function is unknown.	25.00	25.00	66.00	65.80	19.10	16.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.32	0.72	-4.00	2	8	2009-01-15 18:05:59	2007-05-10 14:43:34	5	1	8	1	1	7	0	65.40	75	99.43	CHANGED	MPKYWSYPVGLAVEINNNARYGCPHHVGRKGKIIEHLHSATYDYAVSDETGDITYFKEHELTPLKGGLAYV	MPKaWSYP.GLcV.INpNA+.uCPHHVGRcGKIIEhLHSATYDYAVSDETGDITaFKEHELNPhKGG..........	0	1	1	1
+9462	PF09630	DUF2024		Domain of unknown function (DUF2024)	Coggill P	anon	pdb_2hfq	Domain	This protein of 86 residues is expressed in bacteria.  It consists of four alpha helices and two beta strands. Its function is unknown. One UniProt entry gives the gene name as Traf5.	20.40	20.40	21.10	69.20	20.10	17.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.85	0.72	-4.27	13	50	2009-01-15 18:05:59	2007-05-10 14:46:45	5	1	46	1	22	46	40	81.50	45	95.21	CHANGED	MclHVaDTaVps+DG+hMHFDVll..sscstc+shpYAKpaLcolG.csssloppECpFCHSEtAss-VppuIcppGaaIhcM	....Mcl+VFDTaV+s+DG+hhHFDVll...sccpst+AhpaA+cWLsuhG.csAsloppcCpFCHSE...tAss-VtcuI+p+GaaIhph.	1	9	15	21
+9463	PF09631	Sen15		Sen15 protein	Coggill P	anon	pdb_2gw6	Domain	The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this hetero-tetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold.  Each monomer consists of three alpha-helices and a mixed antiparallel/parallel beta-sheet. Two monomers of Sen15 fold with two monomers of Sen34, one of the two catalytic subunits, to form an alpha2-beta2 tetramer as part of the functional endonuclease assembly.	22.00	22.00	22.20	22.10	21.80	21.60	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.41	0.72	-3.78	44	217	2012-10-11 20:44:46	2007-05-10 14:48:09	5	8	184	2	146	215	1	113.10	26	62.71	CHANGED	hVhtsLhchptWp-Vcl..hppp...t.......................lhllpGpPspphstp.................................EhllPlph....sptlolcplcplFspl.....s..t......................sp+llLAIlssDuTlVYYh...lpcGlhc.....Pcp.s	.....................................................................................VhhsL.ct+.Wpplph.ht..p.hp.....................hhhlpGh..ct.hh............................................phVlPssh.........spphohpplpplac..tltt.t.t.............................................spplhLAhlp....s....DuTlVYYh..lpcGhhpPc..............................	0	37	71	113
+9464	PF09632	Rac1		Rac1-binding domain	Coggill P	anon	pdb_2h7o	Domain	The Rac1-binding domain is the C-terminal portion of YpkA from Yersinia. It is an all-helical molecule consisting of two distinct subdomains connected by a linker. the N-terminal end, residues 434-615, consists of six helices organised into two three-helix bundles packed against each other. This region is involved with binding to GTPases. The C-terminal end, residues 705-732. is a novel and elongated fold consisting of four helices clustered into two pairs, and this fold carries the helix implicated in actin activation. Rac1-binding domain mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and causing cytoskeletal disruption in the host [1]. It is usually found downstream of Pfam:PF00069.	25.00	25.00	43.00	42.30	23.90	19.00	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.76	0.70	-5.34	2	33	2009-01-15 18:05:59	2007-05-10 15:45:29	5	2	30	3	3	15	0	287.60	85	40.67	CHANGED	DsRRlTP+KlRELSDhLRhHLSSAuT+QLshGhsLSDLssM.ssLDKAERpthsDpsQlKSFNSLILKsYuVIuuYlKGc.s-oKospsEsSP.hpuNhMhSlsEPoLppIQtpLsQoHu.sDIuoL.Ru+pHLETLLpVLhs.S.Q.p.VosEsYsFL.RlAEsKsoLu.pLssLptQQpps+upLShLhptssuWAssARQuL.RFDShRPVVKFGo.Q.hAlHRpMhAAaAAhTLQEVutFss-MRpFsAsuhPLLhQLGRSoLhDEtLs.QREpLRELsTlAERLNRLppEWh	.......DVRRITPKKLRELSDLLRTHLSSAATK..QLDMGGVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYRVIE.DYVKGREGDTKNSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSDIGSLVRAHKHLETLLEVLVTLSQQGQPVSSETYGFLNRLTEAKITLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTVDSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAERLNRLEREWM.	0	0	1	1
+9465	PF09633	DUF2023		Protein of unknown function (DUF2023)	Coggill P	anon	pdb_2guk	Domain	This protein of approx.120 residues consists of three beta strands and five alpha helices, thought to fold into a homo-dimer. It is expressed in bacteria.	21.30	21.30	54.60	54.40	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.26	0.72	-4.07	10	133	2009-01-15 18:05:59	2007-05-10 16:32:13	5	1	133	2	35	108	1	100.10	53	83.50	CHANGED	+lFhHHIYEapKGlRsLlLhTLsscttstshtRLcppuIsYalQcs.ups+lNlFFGsspClcslRplss.+PLspLTsEEDFlLGuMLGYDhppQCcRYLpR	..+lFhpHIYEacKGVRphVLaThs+capshAlpRLcppsIsYhIQ.V..uss+lNLFFG+pECl-slRtllp.+PLNpLTPEEDFILGuMLGYDlptQCcRYCpR..	0	12	24	29
+9466	PF09634	DUF2025		Protein of unknown function (DUF2025)	Coggill P	anon	pdb_2hg6	Domain	This protein is produced from gene PA1123 in Pseudomonas. It contains three alpha helices and six beta strands and is thought to be monomeric.  It appears to be present in the biofilm layer and may be a lipoprotein.	25.00	25.00	170.10	169.90	24.20	17.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.24	0.72	-4.29	5	33	2009-01-15 18:05:59	2007-05-10 16:37:21	5	1	33	1	11	25	1	106.00	75	96.84	CHANGED	MSITSppICQAADQLKGFVGFNRKTGpYIVRFSEDSFGMDVADDoIlPsSEFVWAsssDssMsLcREpLQLLLEQNIDDRlNIoEPLRVYLRRoDLPEIpApRSLl	MuITSsDICQAADtLKGFVGFNRKTGpYIVRFSEDSFGMDVADDSITPTSEFVWuuspD.ssMpLsREpLQlLLEQNIs-RLNIGEPLhVYLRRpDLPEIsAQRpL...	0	1	2	7
+9467	PF09635	MetRS-N		MetRS-N binding domain	Coggill P	anon	pdb_2hsn	Domain	The MetRS-N domain binds an Arc1-P domain in a tetrameric complex resembling a classical GST homo-dimer. Domain-swapping between symmetrically related MetRS-N and Arc1p-N domains generates a 2:2 tetramer held together by van der Waals forces. This domain is necessary for formation of the aminoacyl-tRNA synthetase complex necessary for tRNA nuclear export and shuttling as part of the translational apparatus. The domain is associated with Pfam:PF09334.	21.20	21.20	21.90	42.10	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.58	0.71	-3.73	5	42	2009-01-15 18:05:59	2007-05-10 17:08:36	5	2	39	1	27	42	3	115.50	37	15.90	CHANGED	KGHoutLQLANNLKLALALtLAsssLKLclNEDcutPpLhsouoGFcLFDANAILRYVLcDFEupcS-cYpaAluSLEshLYH..K-ssc-HlsclsNKuL-NYL.lsh-EPLoATcLIlFANsY	.......Ktpsh.LpLANNLKlulAlphhs.tsL..clpls.-Ds..us...hpLhsspss.FpLh-sNAIlRYlhsDFps.ppu.cap.....hpshLYp....Kp..ppclp.hss.tltpah....cp.losoplIlFAslY.....................................................	0	3	14	26
+9468	PF09636	XkdW		XkdW protein	Coggill P	anon	pdb_2hg7	Domain	This protein of approx. 100 residues contains two alpha helices and two beta strands and is probably monomeric. It is expressed in bacteria but is probably viral in origin. Its function is unknown.	23.00	23.00	23.50	23.30	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.55	0.72	-4.18	4	40	2009-01-15 18:05:59	2007-05-10 17:10:23	5	1	35	1	9	35	41	96.80	32	88.42	CHANGED	M.Lh-AIhYpYPsAsspKDF.lRNDGDG..SYIpcWplcAPhPTEtELcsWWEEhQpNPsY-PP.Ql-hLAQELupEKLhRKQLEc.sppLGsELSslKLplLsLKG-	..........................................................lh-slhahaPssss.hDa.lpssup.G...hItcWplp.hP.PTptpLcphac-htcs..sshpsPspl-hLuQ-LupEKLtRKph-ph.psLGppLuslKLplLplKGt........................................	0	4	6	7
+9469	PF09637	Med18		Med18 protein	Coggill P	anon	pdb_2hzm	Domain	Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators [1].	20.70	20.70	21.10	20.80	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.51	0.70	-4.84	26	307	2009-01-15 18:05:59	2007-05-10 17:12:11	5	6	206	12	211	292	0	171.20	21	91.12	CHANGED	pELhLhuSlsspshpphlppLpuLsu..p..Ppphtchphla+...s..........p.t...lpspstthpphhh+htpphspt.................hh....................p.s...tp...........................................ppsWpLphtDhP-sGp.spsssspphhsssl..............................................................................................pssslhpalpchG.achshEYhhcGhhFhp.uslhItlh+lhp.hsspspt...................p.hshSssallcs.lslscus-h.-thspuhtcL.tlp-pL+shlpLEhsDR..hDoR	...............................................................................................ph.L.u..l.t.t.th..hhp.Ltshss.....s..h.phphhh................................................................................................................................................................................................t..aplph.s.......Pt.s....p..tp....s.......p..hhp..................................................................................................................................................ptsh.thhtthG.ath..pahhtGhhahh.s.hhl.l.+hh..h....tt.................................p.thhlph....h.h.tstp.....t.t......htp.Lpshh.h............................................................................	0	63	97	163
+9470	PF09638	Ph1570		Ph1570 protein	Coggill P	anon	pdb_2hq4	Domain	This is a hypothetical protein from Pyroccous horikoshii of unknown function.\	   It contains six alpha helices and eight beta strands and is thought to be monomeric.	20.70	20.70	21.30	24.10	18.10	20.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.74	0.71	-4.42	4	13	2009-01-15 18:05:59	2007-05-10 17:14:26	5	1	13	2	11	17	0	152.10	56	97.29	CHANGED	MhCEEKLEVFENGF+D-KFNlElcaYGpDuRKVLLAlIYELYLP-YGpEYVYPFECAKEFWsIYhDusElcsEEscLKPlKFlSESVhpKlcc.LccIcsPlEVK....lEcAclYKsK-GYLslGKNFlLD.+GRLFIFNKPSluEhILKYIWcW	................................MhCEEKLEVFENGFcDGKFNlclEaYGpDARKlLLAlIaEL.YLPDYGp-YVYPFECAKEFWGIYhDuuEIpsEEh+LuPlKFlscSVhsKLEcsLc-IcAPtEVKt.lslE+A-laKlKcGhLslGKNFlLDt.+GhLFlFNKPSstElILKYlGh............	0	1	1	6
+9471	PF09639	YjcQ		YjcQ protein	Coggill P	anon	pdb_2hgc	Domain	YjcQ is a protein of approx. 100 residues containing four alpha helices and three beta strands. It is expressed in bacteria and also in viruses. It appears to be under the regulation of SigD RNA polymerase which is responsible for the expression of many genes encoding cell-surface proteins related to flagellar assembly, motility, chemotaxis and autolysis in the late exponential growth phase. The exact function of YjcQ is unknown [1]. However, it is thought to be a prophage head protein in viruses [2].	21.80	21.80	22.20	22.10	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.14	0.72	-3.90	8	83	2009-09-10 15:07:02	2007-05-10 17:17:20	5	1	76	1	15	64	1	92.60	25	87.98	CHANGED	tYKILptlhauaEshpc.D.slhD........cphscsLphLpD-GYIKGlphp.s....slhsuhssshlTh...cGlsYL-ENohhKKAYKshKEl+-WlP	.........Y+lLphlht.s..h..cphpth.c...s.hhp.......lspphhsphlphLh--GhIcGlphhpth.......phhh.t.h.pshpITh...cGlcYLp-NShhpKshchhK-hpt.............	0	9	12	14
+9472	PF09640	DUF2027		Domain of unknown function (DUF2027)	Coggill P	anon	pdb_2huh	Domain	This protein domain is of unknown function. though putatively involved in DNA mismatch repair. It is associated with Pfam:PF01713.	25.00	25.00	45.80	45.00	23.00	22.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.95	0.71	-4.88	5	110	2009-01-15 18:05:59	2007-05-11 10:06:21	5	2	110	1	14	104	3	160.50	48	43.58	CHANGED	LNVaLAYVPpDhKAluTTPFETYLVNDSNYYLYYTYLSAEGsuW+sRSHGlIEPNTKLaLEEFsKu-LNDhERVsVQLIAFKDsKsFslKPAVSVELRIDTVKFYKLHTFpEoDFFEEPALIYDIV+NDhPVKQVaVSAEELKEALlQKKssD+s.pPQsllK	..LNVaLAaVPpD.hKshsoTsFEsYLVNDSNYYlaaoYh..ou.EGp.u.WpsRupGhlEPNTKlhlEEFs+ssLN.-hE+lsVQllAaKcsKsahlKPAlsVElRIDsVKFYKLHTFp-sDFFEpPALlYsIV+sDhPs....+plh..VsAc-lppuhhpKp..t.-.t....h...........................................	0	5	12	14
+9473	PF09641	DUF2026		Protein of unknown function (DUF2026)	Coggill P	anon	pdb_2hly	Domain	This protein of approx. 100 residues is found in bacteria. It contains up to five alpha helices and up to seven beta strands and is probably monomeric. Its function is unknown. It is cited as a major prophage head protein [1], so might generally be of viral origin.	25.00	25.00	156.50	156.40	22.30	18.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.31	0.71	-4.95	4	14	2009-01-15 18:05:59	2007-05-11 10:08:21	5	1	14	1	5	16	1	201.70	47	95.83	CHANGED	sLoDY.RIYpVl+uVLhS.tsAcss+AChFFuhhGAaILpcHY+lcA+shuGhhuathu..hsslLhFu.pIEcsplpSu--sFHsWVpsDsallDFMAPhFsEshtut.hshslPtKMhQR+L-sMAsS.ssL+puGDFhahPs.-lTpcLtt+htppth.tDllslsssWatKpPpphssoluhsDt+GpssplsLsssp.lhGAW	.p.oDYpRIYRVIpSlLlu.pNADsAsAshaFSTFGAaILppHYKlcAhPpuGhAAYsLG...uslLhFu.+c-DGh.VsuAs-sFHCWVEADGWAIDFMAPtFupuscu....LslPsKMFQRsLuuMAsSlsDLspSGDFFYcS.-s-sTschhsDacppshluDlusVAssWFRKoPKpMssSlols-pcGcsp.plPLoGps.lsGuW	0	1	2	4
+9474	PF09642	YonK		YonK protein	Coggill P	anon	pdb_2h4o	Domain	YonK protein is expressed by the bacterial prophage SPbetaC [1]. It is a 63 residue protein that associates into a homo-octamer in the form of a beta-stranded barrel with four outer helical features at points of the compass.  Its function is unknown.	25.00	25.00	29.70	29.60	21.30	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-8.81	0.72	-4.28	2	10	2009-09-11 09:12:47	2007-05-11 10:17:06	5	1	10	4	2	7	0	60.00	48	94.94	CHANGED	ASKKVHQINVKGFFDMDVMEVTEQTKEAEYTYDFKEILSEFNGKNVSITVKEENELPVKGVE	.........h.uKKVpplNlKGhhDh-sspIpEpsK-sEppYDLsElLScFsGKpVSITIKEEsELPhc...t..	0	1	1	2
+9475	PF09643	YopX		YopX protein	Coggill P	anon	pdb_2i2l	Domain	YopX is a protein that is largely helical, with three identical chains probably complexing into a twelve-chain structure.	22.40	22.40	22.80	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.15	63	761	2009-01-15 18:05:59	2007-05-11 10:26:09	5	2	545	9	61	587	31	122.40	24	92.72	CHANGED	KFRuasctppchh.spthph...phtthhhtp.tpp.t...................................l...hQaTG..LKDKNGpEIaEGD.....Ilch....t..h..h..........................pat-sphhhhht...............................phh..h.hpspsh..EVlGNIa.ENsELLE	........................................................cFRsaspt..p...pthh...htt.hph.........pt.h.h.h.tt........t..............p........................l..hQh.TG....LKD..KNG....pE..IaEGD.....Ilph......ptt.tthh..........................................hpapcsthhh.ht...................................ph.h......h.h.......t.....pph.....EllGNIa.ENs-LLc..........................................................	2	18	46	56
+9476	PF09644	Mg296		Mg296 protein	Coggill P	anon	pdb_2i15	Domain	This protein of 129 residues is expressed in bacteria. It consists of three identical chains of five alpha helices.  Two copies of each chain associate into a complex of six units of possible biological significance but of unknown function.	25.00	25.00	113.30	113.20	20.20	18.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.66	0.71	-4.26	3	8	2009-09-14 14:07:04	2007-05-11 10:29:33	5	1	8	3	3	5	0	116.10	52	95.77	CHANGED	KPQLlAaKpFLQTEFpcVDFETFRpNFNLCLEREQcTllIYEDDDYDDQsFFhKPMLSDuFFIpoEVIKQL.DaLAcLV-NPKDDDKpCC...QsFYEALhlFISALAITKGIslsRaHQpLssR	p.pL.thhp.lpp.hpclshEphhpNaNhhhEppppThlhY-DDDY--.sFF.Ksh.u-h.alpsclIppl.DaltcLlcs.hDDDKphs...ppFYp....hhpAlAlTKsIslpRhpphLtsc	0	2	2	2
+9477	PF09645	F-112		F-112 protein	Coggill P	anon	pdb_2cmx	Domain	F-112 protein is of 70-110 residues and is found in viruses. Its winged-helix structure suggests a DNA-binding function.	22.40	22.40	22.80	45.00	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.57	0.72	-4.17	2	4	2012-10-04 14:01:12	2007-05-11 10:36:56	5	1	4	1	0	5	0	93.00	37	97.64	CHANGED	QolN..chAp.haphLccKtElThEDIlA.aplosssAYsI.psLKshCppH.sECps.h+sRKTs.......................................IhuKQ	....lNshphAclhaKILppKtElolEDIlAQFEISsosAYsI.+sL+hICEpH.-ECpsppKsRKTlhh.hKpEphppptpEp..ppItKIhsAps...............h...	0	0	0	0
+9478	PF09646	Gp37		Gp37 protein	Coggill P	anon	pdb_2gjv	Domain	This protein of 154 residues consists of a unit of helices and beta sheets that crystallises into a beautiful asymmetrical dodecameric barrel-structure, of two six-membered rings one on top of the other. It is expressed in bacteria but is of viral origin as it is found in phage BcepMu and is probably a pathogenesis factor [1].	20.50	20.50	21.00	21.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.56	0.71	-4.74	13	105	2009-01-15 18:05:59	2007-05-11 10:50:08	5	1	99	6	20	81	0	141.20	42	92.06	CHANGED	llsRL+ppLPphplEhFP-cPscYpLsHssGAlLluYtGS+FspPcDTsuVlQsRplplulTVlhRpLsucpGAlssLDplRpsLsGF+PPsC.pchaLlsEpFlG..EssGLWQYsL-hsTETltlE-s-spssPhLspVs....YEcp-	.............................VhsRL+Et.P.p.hp.lch.spcsppYh.sp..uslLlpYsGSpFscP-sTsAllQpQplplssTVlstQlsst....tAls......sLDplRpuLGGap.PsC..cR.lWLppEpalG..-ssGhapYsL-hsspolFIt-p-s.pcu.PLLTtVN....YEE.................................	2	5	15	17
+9480	PF09648	YycI		YycH protein	Bateman A, Szurmant H	anon	Pfam-B_6483 (Release 21.0)	Family	This domain is exclusively found in YycI proteins in the low GC content Gram positive species.  These two domains share the same structural fold with domains two and three of YycH [2] Pfam:PF07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.	25.20	25.20	25.30	25.20	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.50	0.70	-4.90	33	732	2012-10-01 23:24:42	2007-05-13 16:43:49	5	2	721	12	94	434	1	224.20	27	82.91	CHANGED	psp.sssppssttlppchcs-pIslss.lsscp.....scshhLsucpcshp..hcshps.....Lpspssshppps........plpushspslpls....................tppttpplpsalp...........pplhpG.....pcYpasph.p....sssplsatQpacst.la........spp....uplphplsscs...clsuYpQohlsclp.hc....c+.pplIospcAlpsLYh..pspltsssc...lppscLGYh......pll..sssspplh.sPsWpltlcpp...s....tthphhhVNAh	......................................................................................................................................................p.......ppps..h-pphpp-pIshs.s..lsscs...hph.hlsucspsFs....tcshps.............lt...spshphpsts..................phLpuslsp.slt.ls..............................cpshccl.pcalp...........pplhpG.......................pcY..p.hsph...................sssplhatQ.p.Y..cshPlh..........ssp......A..hls.h.plppcs...cls..SYp..Q...o.hhs...clc.hc.......c+...pplIospcAl.-sLYh.......ppt..lpp..ssc.......VhpscLGYh.......sll....ptsss...plh....hPsWplplcpcs.......tpsphhhVNAh..........	0	30	60	76
+9481	PF09649	CHZ		Histone chaperone domain CHZ	Wood V, Coggill P	anon	Wood V	Domain	This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones [1].	23.30	23.30	23.40	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.84	0.72	-4.72	25	201	2009-01-15 18:05:59	2007-05-14 09:24:18	5	1	169	1	137	189	0	37.30	40	13.89	CHANGED	---sD-LppIDsuNIIosGRRTRGKsIDFspAAcclps	................c--p--Lt.pIDsuNII.o..uG.RRTRu+slsastsupph......................	0	29	66	104
+9482	PF09650	PHA_gran_rgn		Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded by genes involved in either polyhydroxyalkanoic acid (PHA) biosynthesis or utilisation, including proteins found at the surface of PHA granules. These proteins have so far been found in the Pseudomonadales, Xanthomonadales, and Vibrionales, all of which belong to the Gammaproteobacteria.	20.50	20.50	20.50	20.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.58	0.72	-3.88	24	217	2009-01-15 18:05:59	2007-05-14 11:17:44	5	1	213	0	80	187	38	89.10	29	90.59	CHANGED	IcIcRpHsLshppARptA-plAcclspcaslcspWp....uDplpFpRoGlcGplplsssplclplcLGhlLpshpupIcpEIcctLDphL	...............................Iplc+sHsLGh-pARp+s-ph...sp+ls...p...c.....a......u.....l.....ppp.....Wp.........GDpl..ph....p.....tp....G....l....cGplsltscplclplcL.shlL.ushpstlcscIc+hLcphh.......................	1	18	39	60
+9483	PF09651	Cas_APE2256		CRISPR-associated protein (Cas_APE2256)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a conserved region of about 150 amino acids found in at least five archaeal and three bacterial species. These species all contain CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In six of eight species, the protein is encoded the vicinity of a CRISPR/Cas locus.	24.80	24.80	25.00	25.10	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.74	0.71	-4.45	28	119	2012-10-11 20:44:46	2007-05-14 11:35:42	5	3	97	2	56	125	1	135.30	23	39.62	CHANGED	cpsSAELNulhphhppt.hs.......phhLlsoDTssGchsApllccalpp............puhp.Vplht..t....lpshs.hcp..Fpc......GLtsLlctlspplp...ppsutp.lhlNsTGGaKspsuahsllu.h..husslhYlaE.phs-llpLPhl	................................................................phSAElsulhph......hppt.ht.........plhLlsoDT.pGchsucllppalpp...................pshp..lphhthts....lpsps...pp....Fpp...Glts...Lhctltpplp...ppp..u.tp..lhlNsTGGaKu.ssah.slhuhh...huh.lhYlaE.p.hscllplP...............	0	32	43	49
+9484	PF09652	Cas_VVA1548		Putative CRISPR-associated protein (Cas_VVA1548)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents a conserved region of about 95 amino acids found exclusively in species with CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In all bacterial species that contain this entry, the genes encoding the proteins are in the midst of a cluster of cas (CRISPR-associated) genes.	25.00	25.00	33.10	28.10	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.07	0.72	-3.98	6	31	2009-01-15 18:05:59	2007-05-14 11:44:26	5	4	27	0	10	31	1	91.80	41	51.20	CHANGED	WhloRHsGAhEWAtc....QGlclD+hVs.HLc...htclstGDpVIGoLPVpLAtslCc+GucYaHLsL.clP.plRGpELoA-phcussA+LtcacVcps	.....aFloRHsGAl-Whtp....p.G.l.plDchls.HLD...sspIpsGDsVIGTLPlpLAAclCp+GA+ahaLoL.slPhchRGpELos-phpstGApLppaplp..h..........	0	4	9	10
+9486	PF09654	DUF2396	CHP02652; 	Protein of unknown function (DUF2396)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These conserved hypothetical proteins have so far been found only in the Cyanobacteria. They are about 170 amino acids long and contain a CxxCx(14)CxxH motif near the N-terminus.	19.60	19.60	20.70	182.80	18.70	17.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.07	0.71	-4.26	7	46	2009-01-15 18:05:59	2007-05-14 11:53:07	5	1	43	0	20	48	1	160.70	74	95.31	CHANGED	PIFGPEIpCPHCRQsIPALTLTDTYLCsRHGAFEAsPcTt-LVHLQSGRpWRLWEspWYRQHTHPDGIRFEIHEALDRLaTQGYRAT+VIIAcRYR-LlssYLERsssh...usscss..RLYGLPVEFSssssp-.....spWpVINF-LEKE.GsshRYPYFRL..F-	PIFGPEIpCPHCRQsIPALTLTDTYLCPRHGAFEAsPcTsELVHLQSGRHWRhWpsEWYRQHTHPDGIRFEIHEALDRLYTQGYRAT+VIIApRYc-LlSsYLE.RsosWR.......up..s..-us.PRLYGLPVEFSP-spc-.....PCW-VINFDLEKE..PGlPh.RYPYFRLF-......	1	3	17	20
+9487	PF09655	Nitr_red_assoc		Conserved nitrate reductase-associated protein (Nitr_red_assoc)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are found in the Cyanobacteria, and are mostly encoded near nitrate reductase and molybdopterin biosynthesis genes. Molybdopterin guanine dinucleotide is a cofactor for nitrate reductase. These proteins are sometimes annotated as nitrate reductase-associated proteins, though their function is unknown.	25.00	25.00	73.40	73.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.85	0.71	-3.86	25	124	2009-01-15 18:05:59	2007-05-14 11:57:37	5	1	119	0	43	126	32	144.80	46	92.10	CHANGED	hFpFEpDFlssLRCIPMsVRhKLDhsGlKLKLsHWtpLopppRptLVchPs-sssplp.saRptLpphspshsss....scsLs.-ssP.sWppssplPptl....pppApphGlt.lolsQWssLssLQRFALlKLoRsGH-N+NhhsAhpEF	..hFsFEt-.s-sLphIPMlVRapLDphGl+lpLppWphLshE-RphLschPs.-..............ssst.......lc..sacctLhchlps+uss....sphh..ts-ppP.uWpsssslP-ul....hppushtGls...o.hsQWtpLsPhQRasLhKLSRps+t.N+sFlPAh+EF....	0	5	22	33
+9488	PF09656	PGPGW	CHP02611; 	Putative transmembrane protein (PGPGW)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are putative Actinobacterial proteins of about 150 amino acids in length, with three predicted transmembrane helices and an unusual motif with consensus sequence PGPGW.	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.50	0.72	-4.67	29	301	2009-01-15 18:05:59	2007-05-14 13:06:46	5	7	274	0	124	284	202	51.40	35	34.98	CHANGED	RsslsllGhsllllGllhlslPGPGWLllhhGLulLupEatWA+RhLchscpp	..........p.hlhllGhhlllsGllhlsl..P.G.P.G.aL.hlh.lGLu.l.LuhEa.WApphLthspt...................	0	46	90	111
+9489	PF09657	Cas_Csx8		CRISPR-associated protein Csx8 (Cas_Csx8)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes proteins of unknown function which are encoded in the midst of a cas gene operon.	25.00	25.00	32.30	32.30	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.61	0.70	-5.76	3	31	2009-01-15 18:05:59	2007-05-14 13:13:45	5	2	26	0	3	31	0	380.60	38	92.76	CHANGED	FDTsLEuSDWRaSATIVGLIpYFcaL-pcY.hcK.pl.ElEDDYLLYNSssINEENYLDFVEKaY....cDsLHHKlVENILp+.-ElTEEpIKlINEKLsANTlMKKlFGKIKFDGTNK-EILDLI-KNRacLIKETFRRKKsLYuNYuNTNpLFsD.sNcsCRLlGYChDsGKKGKSTGYNFssSTF-apD-KIFDFIPFAFoG.SaEAFFINDNloIccLK........................KSNchIpcKhp--hEGppNScssRpTLFsslpEouDYIKaDVEVILKsRDKEYFETlYlRcESIcIFKE..sEDF-YKuI+F.aKlTDKYYhNlpcEVssuILNslLLDslIElLLK-KNs................aSYsIppLIKINsLIRcGGKEMcE+LKuAa.ACAKpVsKKl..cNppNKLsSYKQKLlSSVlFKD+DRlC-ILLQLSsYSGVhFuFAYDLaEDFEpNKDLAYTFINAL	.........aDptlpsSDW+aSAAIsGLhhYhp.hphpa................h....pt..p...chp-....salhYsppsI....s....Ec.p...YLpFlEcaa....p-phhH+tlEs.Lpp.ppFo.E.IK.Ip-phpANolhKKlFtphKFsGpNccElLpllpcNR..lI+ETFRNtKshYsNasp.....splhpc..pppsCRLhGYhhD.s+KsKuhuasFspsohsa.D...FDFIPFAFot.sh-shFlNsNhslchL.........................Kppptlt...p...pp.hc.t.tp..pphsh+p.hht.hpc.pscaIcashE.....lIhKsp........-c..c.Y.FEThalRpcuIclhcp...hcchp......hhs...lph......Khs-ph....YhslhpEVhssILNh.hLsp.....I.....hLLK..-.cps...........................hsYh.IppLI+lN.hIhp.....ts.ppMp..p.......phctu......h.AsAtpVscKh......st......NKltSY+pKLhSsllhKsacRhhplLhQLSsYSsV.FsFsaDh.hEs.ppNcslhahFl.tL.........	0	2	3	3
+9490	PF09658	Cas_Csx9		CRISPR-associated protein (Cas_Csx9)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes archaeal proteins encoded in cas gene regions.	25.00	25.00	26.30	25.80	22.20	21.80	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-11.97	0.70	-5.65	3	8	2009-01-15 18:05:59	2007-05-14 13:47:11	5	1	8	0	6	9	0	349.00	46	88.05	CHANGED	MSWVVMDAGLEPDcEELADALEGALcSLcSRs+INTSKIGRNDRNSFD+VLpAWFGRSAPETYGELFELVIsETIKLLR-GKIDPucSLSTIKTDKNGTYLGlAYNGEQAILPAIIKQPEYYEaQSuFLKPTTGQKAQIRMDPLWFSFMALGFFTSFAGFIuGKYYLMTKPGIEVFWPYEVEEIIE+GILPLTuAGASGRISLoTEELYEMKLAMKLAEEGRcVIEEVYPVTLHlISLEGQVYTELKTlQLNLpELSNYlsEYVKKIEuu+VGGlsLLVELKEGsATlcKYPLWALVDIAEKELWKGVsGDcEMLAYIFVKDLYRAINSGRKELIcDSIFRLFRQGRALLEGSGRASGEFRKVMRTFMWEEHLEVLL	.......hSWlVh-AGlEPDpp-LA-ALEsulcoLcpRh+.hsoS.....KluRNDRsSacKVhpsW.....FshpsPETYsELFELlIcETIKLL+csKIDPucSLpoIKhDKNGTYLGlsYNGp.AILPAI.IKQPEYYEaQScFLoPTTGpKAQIplDPLWFSlLAlGFLTuFAGaIGGKYYLMTKPGIEsaa..........PYElE-Ilccull.LTsAGhpuRhSLpsEELYEh+LuMKLAEEt+pl.-clYPlTLHlISLEGQVYTELKTlQLsLppLspYhpcYlc+IcshphhuhslhVcLK-s....pKYPLWALlslAE+ELhKGVsGDpEhLAYIhVKDLYRAINSG++ElIcDolFRLFRQGRuLLEGp..u+uSG..EhRKVh+sFMhEcHLtVLl......	0	0	0	1
+9491	PF09659	Cas_Csm6		CRISPR-associated protein (Cas_Csm6)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	21.40	21.40	23.90	23.10	19.80	18.30	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.17	0.70	-5.83	4	211	2012-10-11 20:44:46	2007-05-14 13:59:36	5	2	187	0	24	168	0	273.70	26	89.77	CHANGED	sh-sEII..hh-sl.sspcaDlFhshFc+aLh.lpsta..-sEIlLNlSSGTPQMcSALhllslhss.shpsVQVoTPt+s.SNtu.paussp.clEphhcsN-DNcs..ss.sRshEssutshpthhlRpshhshIssaDYpuALsIlus.ppF.....l.-pl.pll......puAhhRc+L..hpt.h+s+.lhs-lh..shhpsDu.pKshpYhLhLslhtpRtplA-hlhpspshhphllcshlcc+h.t.lh.c...sc.aLsDph..pcthL.-p-splhph..Lccs...ccpshsspphLshhsalslLphhtPsppllttlpsltslpu.lRNssAHslsslspcp.hp.ht.lLStphlKph......hh.phhphppssaNhY-+hNcElhch	........................................................................................................................................................................................................................................pttlp.LlspYcYptAhplupp...t...........spph..Ll......chhhcRp....cL..............................t...pp.hl....h....s.c...hh......hh.h.pt-...........p......p..l.s.pYlhsLp......h+h+ptplhDFlRuloPhl....hhlhhph.lp..p....clP....................tcph..pt.....h...h.h.......t.thh......p.p..p....lhpt.....hp.p..........pshss..........c.t..hlthhs.hh.....p....l..l......h.t..sp.....l....hphl.p.LpphEppVRNslAH.Ips.hsE-....cl...p+s.st..h...up.t.h..........lc.l..............hp.h.st...p..t.t.h......h.aDphNt.lh...................................	0	4	6	18
+9492	PF09660	DUF2397	CHP02677; 	Protein of unknown function (DUF2397)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).	20.80	20.80	21.10	20.90	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.44	0.70	-5.90	21	146	2009-01-15 18:05:59	2007-05-14 14:13:19	5	4	129	\N	63	150	5	439.70	25	93.17	CHANGED	.hpYls.u-puspYRsIhR.sFhtttpphphhLps.--V...lstLtt.tphhsch..........t.cplptcLcQLscWGNLtsppDTu+.ssolt-Fcp++ahYQlothuhplERhltplpssh.spsu.uLpsshLcclhppLppLtphs........ps-stc........laphhpcLhssFpsLspsupsahupLtpshs.pcphcs-sFluaKcpLlsYLpcFltcLtppuspItttLtplptptlc..plLptsspt-tt.st............................s........................shtcthschts+WpuLpsWFlupsu.csspschLpctsppAIspllpslpRlsEp+sstssRcs-hcpLAtWFupsss.-pAHcLhsssFGltpsRHLpss.......stc.ssshssuha-uPPlclshphRppGpttppspsutl.D+stp+cthttphtpcppptctthppL..sssstlclupls..LsspshphhLplLucAhs.......p.....ttsspo-sshplpLp.hss.sphshlcoscGsLphs-ahl	...................hpYLs.s-ss.spYRhIhR.hFhtth.p+h.phhLh..--V.......hphlpp..shhtch..........s.-phppsLppLsc...Wt..NL.st...pDs..u+.spTlpEa..cp++ahYpho.huhplcRhlhplpphh..ttsu.uLpsshhcclhppLppltphh...........ptstpc................................................lhphhpcLtssFppltpsspcahupLts..............hhs....pp...h.psctFlhaKcpLlpYL....ppFltsLpphu.pItthlpplpt.p.tlp.....pllpphsph-hthst..........................................p..............s.pphhpphts+WpuLptWFhu.pss..t.spsptLtptspphItplhthstclsEpppttssRpp-hhpLAphFsps.s...ppAHpL.ussFGlh.sRHltss.......ptc.s.shspu.ha-tsPhplshp.Rppshpppt.ttsshh.Dpstp+pthhtphhppp...ppppthhtpl..hpsstlchs.pls....lsstspphLLphlucAhs............p.......tttsps-suhphplp..ts...tptshl+stcG.pLphPshhl.................................................................	0	24	50	58
+9493	PF09661	DUF2398	CHP02678; 	Protein of unknown function (DUF2398)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).	22.20	22.20	22.30	23.80	19.90	22.10	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.99	0.70	-5.73	18	150	2009-09-11 13:39:07	2007-05-14 14:29:58	5	4	127	0	66	155	4	340.50	24	84.48	CHANGED	lRsLLspPhlsp.sp-sEhathV+Rc..pstL+caFpcchGapLlVss..phARLtKhPssspsshshtch......hps+cYshLCLsLAhLEs....sspQhsLucLs-plp.Atss-sshs.....hshsshscR+ulVpsL+hLlslGllptsDGct-sFspcp.....s.u-sLY-lsttshthLls..hsps.uph............pshs-hs.pcshssssttpst..........RpRlhR+Ll.sPVlahc-Lssp-hsYLpsppp.tltcclp-hhGhhhEhRuEGlhhl......cs-c.phssshaPcsu........o.lucssLLlsptltpch...t.sphsts...........lstsclpshltcltpc...asssWp+..ttcstu.scLscpllshLpphtLl.........pt.s-t..lhhhPAsAR.......ausph.ss	.............................................hchLLpp.hlhp...tp..-.-ha.hl+..cp..tptL+cahtcphGapLllss..ths+LtKhPsps.c.s...hhshtph.........p.hcYshhC.lhLAhLEc.......stpQhhLupls-hlp..sths..t.t................h-hsthpcR+uLVcslchhhphGllphsD....Gst...-taspst.......s.s-sLY-ssthshhhlhs..hspshtph.....................................................pphpshh.pp.ph.s.sp...pt.pt...hh...........Rp+lhRpLl.sPsVYh..p..chssp-hhYlpp.+t..tltp.clpchh.Ghthch+tpuhhll........sps..phhs.hFPsps........s.hsclsLLlsthltpph.................th.....s....h.......................ls.tphtthltcltpc...htshWt+....hpths...tplhppslphhpphthh...................................ph.tct...lhhhPhhu+htst...t.......................................	0	23	51	60
+9494	PF09662	Phenyl_P_gamma		Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this protein family are the gamma subunit of phenylphosphate carboxylase. Phenol (methyl-benzene) is converted to phenylphosphate, then para-carboxylated by this four-subunit enzyme, with the release of phosphate, to 4-hydroxybenzoate. The enzyme contains neither biotin nor thiamin pyrophosphate. The gamma subunit has no known homologues.	25.00	25.00	26.60	26.50	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.82	0.72	-4.27	2	10	2009-01-15 18:05:59	2007-05-14 17:47:31	5	1	5	0	1	10	0	81.30	43	96.10	CHANGED	MNQWEVFVMD.AELPEGppLELSVRTLNPGLKKYTYQRV+AElSsALDKFPDpLQVRhGRGQLssQpFSIRIIEpVQRMPAKYL	...........................M.pa-lFl.sLsELsEGpELELpVRDLTPGlHKYsa..+hVKApVSucPcsaP..-+LhlRFGRGQhpspsaSI+llpclp+hPt+aL......	0	1	1	1
+9495	PF09663	Amido_AtzD_TrzD		Amidohydrolase ring-opening protein (Amido_AtzD_TrzD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are ring-opening amidohydrolases, including cyanuric acid amidohydrolase (EC:3.5.2.15) (AtzD and TrzD) and barbiturase. Note that barbiturase does not act as defined for EC:3.5.2.1 (barbiturate + water = malonate + urea) but rather catalyses the ring opening of barbiturase acid to ureidomalonic acid.	25.00	25.00	31.10	94.90	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.12	0.70	-5.88	10	66	2009-01-15 18:05:59	2007-05-14 17:49:48	5	2	60	0	33	66	9	335.60	48	98.20	CHANGED	s-VaRlPhcuPuDVSGLAsLI-sGtlcPscIVAVlGKTEGNGCVNDFTRsaATpuLpslLuc+lshu.cEV.s+lAhVMSGGTEGVLSPHhTVFAt+cspcssps...s+RLAVGhAhTcsLLPE-LGRtsQlscVAAAV+sAMcDAGIsDPuDVHFVQlKCPLLTscRIpsAcuRGcslATcDThcSMuaSRGASALGlAlALGElsuuploDpslhpDauLaSsVASsSAGVELhcsEIIVlG.SsshuGcLsIuHAVMpDAIDscuV+uALcclGLtss.......sscttuRLVNVFAKAEAussGpVRGRRHTMLDDSDIssTRHARAsVGGVlAulsGcstlaVSGGAEHQGPsGGGPVAVIAct	.....pVh+lshpuPuDsSuLtthIssGhlpssclVAllGKTEGNGsVNDaTRthAstuhppsLup....+hshs..p-.......V.pplshVhSGGTEGVlSPHhTlFspp....ss.s.sstt.ss....ttRLslGhAhTcshhPE-lGRhu.lpcsAsuV+pAMtcAGIsDPuDVHaVQlKsPLLT.ppItsApuRGpsssTcc....ThcSMuhSRGASALGlAVA....LGElshs....hsD...pslhpDhsLaSulASsSuGlEL.cspllVl......GNutshuGphtIuHuVMpDAlDhsulhtAlcshGlp.s.......ts.ts+lVsVFsKuEAsssGplRG+RpsMLsDS.Dl.p.pRph+AsVGGlhAulsGcsslaVSsu..ApHQGPsGGGPVAsIsc.h...	0	14	28	29
+9496	PF09664	DUF2399	CHP02679; 	Protein of unknown function C-terminus (DUF2399)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Beta-proteobacteria). Just the C-terminal region is ioncluded here.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.05	0.71	-4.35	17	184	2012-10-01 21:47:57	2007-05-14 17:52:04	5	5	172	0	66	266	4	144.40	25	38.01	CHANGED	hpLoLRpltphts...shsspup........VaVsENPsVhushhDp.....s...........tssPLVCTsGpPssAshtLLstL..sssGspLtYpGDFDhsGL.tlAsplhpRasscP..WRhsssDY........htussssslsspsls......ush.spLspshtppuhsshpEtllstLlsDL	.............................................................h..lsLhpltth.t.....h.s.sspt........lallENsuVhst..hhpp......t..................tshsLlCs...sGp..ss....h.u.s.h.hLlctL........tts..G..s...p....lhY..p..GDFDstGl.tIAspl.....h.......p....p.....a..s.....t.....p.......a+hsspsY.............................hts.h.s.t...t.......h.s.tp......p...hp..h..t..tl......s.....s.........tlspthpph....thsshpEtlht.hh..................................................................	0	29	51	60
+9497	PF09665	RE_Alw26IDE		Type II restriction endonuclease (RE_Alw26IDE)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this entry are type II restriction endonucleases of the Alw26I/Eco31I/Esp3I family. Characterised specificities of the three members are GGTCTC, CGTCTC and the shared subsequence GTCTC.	21.50	21.50	22.20	400.30	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-13.08	0.70	-5.79	7	16	2009-01-15 18:05:59	2007-05-14 18:17:05	5	1	14	0	1	14	11	493.30	51	93.32	CHANGED	cPpFl-Yh+hIlpHPNYtGMPsshttcGcIpWpssSs+poG.Fhph.ppRhtWWcpKAcplGls..sspsthhopsA+hIHPTthKPC+hCG+.hslsYhYPs+shhp+lpK.....-pF.l..sp.ppIsclhspLhphhu-phhpph.thlhscth.phschsssh-talp.l.ppalspt.phLSPGsMuNsPDRhDGFHoaNtCCRuppDpGRpcENL+SYopDRRuFEaWsDGsWsAADpLM.....Gphthssphh...pl............SADHIGPISLGFsHcPpF.p.hCpusNSuKNsRhhhsDlppLlchEs.pucsVuSWasctlW-hhKcsV......sss-sshp..hSphLRsNpchahplLhclhp....sGpthhLushLp.cY.....ApashsF-slphpsphhphpslpp.p+hTchsptppsRtlRIAFEuLp-YspK..EsRphhts.s....cp.pphls.hhp.lp........hhs-plsp.lppss.p-c.hpslh...........tp...h+chLhphMshluccltp	..stFLEYs+hIVsHPNYhGMPDshGccGcIQWEAPSNRuSGpF+cTaQ+RhcWWcsKA+SlGID..soEpuWISKTAKLIHPhGhKPCKpCGKpM-LuYuYPNcpFhuRl+KLsYlDEoFEL..opsEHIlDLlsRLccpaGEcla.DLP+LhssKol.sIPcloSsL-sWIcaLcEpYIPpEu+hLSPGAMANPPDRFDGFHSaNRCCRShADKGRoKENLKSYsTDRRsFEYWVDGDWVAADRLM.....GplRo.NNhhh....pEECLNsst....PsPCpADHIGPISLGFuHRPpF.QhLCKSCNSAKNNRMYLSDlhpLL-AEN.EGcoVhSWaucclWs+lKHoV......cDsEcAlR..LSKlLRDNRHTYMpLLc+Ihc....-GaasFLAolL+LEh.....ANYs.hFEGLsISNHlTcYcSl+K.++pochsthpcsRplRIAFpuLp-YtpK..ENRNshhVss....c.ppphhschh.ppLpuhsp.h..ppLs-tlst.l.pp..pcpphpslhptl....h..t.cpaphhhchL.phhs.lGcpht.s.....................	0	1	1	1
+9498	PF09666	Sororin		Sororin protein	Bateman A	anon	Bateman A	Family	Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion [1]. The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex [1].	23.00	23.00	27.50	27.50	19.40	18.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.09	0.71	-4.05	14	61	2009-01-15 18:05:59	2007-05-15 14:10:46	5	2	42	0	29	58	0	126.90	37	35.78	CHANGED	ENhPP.........hsppshhhssstsspssps.V.lPsstcolQp+ushcslsIl.......WpKpV......cpo.oR.phs..............................ts.pssoPp...tp...............s+psLFGFEchLssE....-h..spssspu+sts.psVo............hpchsp.tssscslPtVs..sh+c	.........................................ENtPP.......p..hppsh.t...sps.sspssps.V..s..hco.ppc.s..hcshsl........MSKKV......RRSYSRLps...............................tsssTSTP.....................uRRShFGFEshLssE....DL.tsuslssSKhhpsspVs................scshsPDpsLPGlSsss.+.....................	0	3	5	12
+9499	PF09667	DUF2028		Domain of unknown function (DUF2028)	Bateman A	anon	Bateman A	Family	This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.	25.00	25.00	31.90	28.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.07	0.71	-4.09	3	80	2009-01-15 18:05:59	2007-05-15 16:21:03	5	4	40	0	31	87	0	124.30	72	15.86	CHANGED	EMPQLNFuMADPTQMGGLSMLLLAGEHALTo................PEVSSGICR.s.St.Pp.ppKSsLFpFsElSSSTSHSDsPAssKQspTSALFQ..FAEISSsTS.sQl+sA-PVKRCGKSSL.............suusptK.CtpSALFQLAEMCLASEAsKMEpS+slcsD-S	..............EMPQLNFGMA..DPTQMGGLSMLLLAGEHALGT................PElSSGTCRPD..lSES....PELRQKSPLFQFAEISS.STSHPD..AsoKQCQsSALFQ..FAEISSNTS..QLGGsEPVKRCGK........................................................SALFQL..AE.................M...CLASEGhKME-SKLhKuKES.................................	0	2	4	14
+9500	PF09668	Asp_protease		Aspartyl protease	Mistry J, Wood V	anon	Pfam-B_9589 (release 20.0)	Family	This family of eukaryotic aspartyl proteases have a fold similar to retroviral proteases which implies they function proteolytically during regulated protein turnover [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.55	12	445	2012-10-02 15:32:34	2007-05-16 13:33:18	5	22	263	6	291	833	24	118.70	41	29.40	CHANGED	ppplpENhppAhEapPEsFupVhMLYlssclNGh.VKAFVDSGAQsoIMS.cCAE+CGlhRLlDTRatGlA+GV.Gst+IlGRlH.splKlGs.halPsuhoVlE.spclDhlhGLDMLKRHQssID	.....................................ptlp-shp..A.hE...tPEsF.s..p..V..s...MLYlssclN.Gp.s.l.K.AF.V.DSGAQ.hT.IMStu.CA..-..+..C...s..l..h...R..L...l.D.p..R.at..G..l.A..p..G..V.....G..o..t..c..I.l....G..+.l...H........s.....pl..p...lts....a.l...s...C......SF.s.V..l.-........s.........p.......s..h....-..h.LlGLDhL+RHpssID............................................................................	0	105	148	212
+9501	PF09669	Phage_pRha		Phage regulatory protein Rha (Phage_pRha)	TIGRFAMs, Coggill P, Iyer LM, Bateman A	anon	Iyer LM	Family	Members of this protein family are found in temperate phage and bacterial prophage regions. Members include the product of the rha gene of the lambdoid phage phi-80, a late operon gene. The presence of this gene interferes with infection of bacterial strains that lack integration host factor (IHF), which regulates the rha gene. It is suggested that Rha is a phage regulatory protein.	28.20	28.20	28.60	28.30	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.13	0.72	-3.63	122	1673	2009-01-15 18:05:59	2007-05-16 13:38:50	5	20	1017	\N	171	1330	10	87.90	27	38.68	CHANGED	ssoShclA-hhsKcHcsVlRsIcphh...........................t........sths.a.tthp.t....s.spspp...hYhl....s+cshhhLlhuao.sttshpa+...tthIctF..pchEp.pl	....................hsoShplAchh...........sKcHcsVl+sIcplttt..............................p..h..sphs.a..psphh...........s.sp.s.cp..h.hYhl....s+cuhhhLlhuho..stts.h.pFK...tth...lptFppMEpt.....................................................	0	39	110	141
+9502	PF09670	Cas_Cas02710		CRISPR-associated protein (Cas_Cas02710)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	22.40	22.40	22.40	22.40	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.34	0.70	-5.83	10	109	2012-10-11 20:44:46	2007-05-16 14:25:52	5	5	85	0	64	132	12	269.30	16	69.90	CHANGED	-slthuIsshpP-+VlFLso...............-pScsp..lscl+...cpsstpspp.........hhshstDssslhcsYcchcsll-+a...thcccplllDhTGGTKsMouGLslAuhsh.....chshsYVsG....csssG+lpsGoE+lpp.psPassauclEtcpAtpLaN+tcauuAhplhcsLspR.lsccps..YshhttLscuYhtWDpFcaccAh-tLc+shsp.sl...........sscppsLpphsslh+sLpshLssttsshsth.c...shsLltDLLuNAcRRAupt+YDDAuhRlYRsLELluQtcLt.shGlsTusss.....hhpclP-tLcpsYcptpsspGht.........h+IuLhsuYtLLpshGDc..lucpa.....htphsclpphlpsRNpSILAHGacs....loccpYcpltDhlpshhpth	.....................................................................................................................................................................................sltth..pP..ctlh.hl.ho....................................ppstth......htp...lh......p.h..th.t.tt.........................hhhh.hs.psh..p....h.a.ct.lpph.lpph........tt..t...pl.hlDhTGGTKsMusuh.s.huuh.h....................sh.p.h.Ylsst......p.t.tps..stp................................................................................................................................................................................................................................................................................................................................................................................................................................h..................................................................................................	0	27	45	60
+9503	PF09671	Spore_GerQ		Spore coat protein (Spore_GerQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this protein family are the spore coat protein GerQ of endospore-forming Firmicutes (low GC Gram-positive bacteria). This protein is cross-linked by a spore coat-associated transglutaminase.	25.00	25.00	65.90	65.60	24.10	20.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.69	0.72	-4.33	19	183	2009-01-15 18:05:59	2007-05-16 14:32:04	5	1	174	0	31	116	0	80.90	67	52.50	CHANGED	GMLPLEQSYIENILRLNKGKpATVhMTYEpuSphGopsasGIIEAAGRDHIVISEPpSG+RYLLLMIYLDYVpFsEEITYh	......GMLP.lEQSYIENILRLN+GKpATVhMTYEpuop..h..sspsapGIIEAAGRDHIlIS-Ppo......G+RYLLLMIYLDYVpFsEEIsY.....	0	10	21	23
+9505	PF09673	TrbC_Ftype		Type-F conjugative transfer system pilin assembly protein	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents TrbC, a protein that is an essential component of the F-type conjugative pilus assembly system for the transfer of plasmid DNA. The N-terminal portion of these proteins is heterogeneous.	20.90	20.90	21.10	32.00	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.44	0.71	-4.47	49	432	2009-01-15 18:05:59	2007-05-16 15:26:40	5	1	316	0	67	337	22	108.60	35	41.09	CHANGED	hlFlShSMPppuL+phhppspph....ssslVlRGhhss...shppThstlppLhppstt.............ssltIDPphFcpasIspVPuhVhsps...........s.spt.t.......spastltGslolphALcpls	........hhFlShShP-puLKphlt-spch.....GhssllRGhsss....sLps.TscslhsLlpcssss.............ulpIDPslFppYsIpsVPulVlhss..........................................psachlpGslplttAL-pl.........................................	1	16	35	54
+9506	PF09674	DUF2400	CHP02757; 	Protein of unknown function (DUF2400)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this uncharacterised protein family are found sporadically, so far only among spirochetes, epsilon and delta proteobacteria, and Bacteroides. The function is unknown and its gene neighbourhoods show little conservation.	21.90	21.90	22.30	32.70	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.43	0.70	-4.66	49	423	2009-09-10 16:07:27	2007-05-16 15:34:14	5	2	396	0	109	346	215	212.90	36	86.13	CHANGED	DPlplsH+apc.pDhEIuuhlsAhhAaGNtKtIlcphccL.hpLhspuPhpalhphp.....tp..hpthpsFh..aRh.supDltthhhsLpplhp..phsuLEshFt................thppssslppulppFhpthhp.h...h..hs.cal..............ssstssSAsKRlNMaLRWMVRpcs..lDhGlWcs.lssupLlhPLDsHst+lu+pL.GLhpRKpsDh+sshElTpsLRclDPpDPlKYDFALatLGhpc	...........DPlphs+hasc.......s.EhhullsAhhAaG.st+pIlphlccL.hslhs..s..s...t.h...................pcp.h.h....pphcshhYRh..stpDlhthhhsLpplhp..c...toLcphFh....................................t.h.p.p...p...p.shhpu.ltsFhpthhph......h.....hs...chh............h...pssssSshKRhNMaLRWMVR+Dp..lDlGlWpp..lpspcLllPLDTHst+luhpL.GLl......c......RK..........phDhKsshElTpsL+clsssDPlKYDFALatlG.s................	0	42	91	105
+9507	PF09675	Chlamy_scaf		Chlamydia-phage Chp2 scaffold (Chlamy_scaf)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this entry are encoded by genes in chlamydia-phage such as Chp2. These viruses have around eight genes and obligately infect intracellular bacterial pathogens of the genus Chlamydia. This protein is annotated as VP3 or structural protein (as if a protein of mature viral particles), however, it is displaced from procapsids as DNA is packaged, and therefore is more correctly described as a scaffolding protein.	25.00	25.00	47.00	46.70	22.70	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.47	0.71	-4.07	4	9	2009-01-15 18:05:59	2007-05-16 15:38:40	5	1	8	0	1	10	48	108.80	40	74.45	CHANGED	IphIVtKhNtsuslpHl....tpRpspYs-CssPhDap-ALssVhcupEtFDuLPA+lRcpFuNsPcEhLp.......aLpc.cNh-EuhuLG..ll..-........hhcst.+csp.sssQppsh	.INpIVAKhNuTGVlpHl....p+RpscYhDC.sPh-YpEALNlVhEApEtFDuLPA+lREcFuNsPcthL-.......FLsc.cNhEEutuLG..hl.t-tp......hhcst.+csp.sssQp.s.l..........	0	0	0	1
+9508	PF09676	TraV		Type IV conjugative transfer system lipoprotein (TraV)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry includes TraV, which is a component of conjugative type IV secretion system. TraV is an outer membrane lipoprotein that is believed to interact with the secretin TraK. The alignment contains three conserved cysteines in the N-terminal half.	21.00	21.00	21.30	22.20	20.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.77	0.71	-3.40	39	394	2009-01-15 18:05:59	2007-05-16 15:56:05	5	2	298	0	59	271	10	128.70	30	69.11	CHANGED	sscFuCsussus....Ctohspshppuhtt..stp.ht........................ssssssssssssssssssshsh...s..h..............................................................Pl.Rsttclh+lhlsPahDsc..GchapsshVahhlcsu...pW	....................................................................................................................po-apCsusssss...Chohcps...ctspphpt.spp.sps.sst.th....................................sss.susps.ssssp...sppthhss...cshhs..tstpsp............................................................................................................................Pl.RosppshplWIAPahD..sp..sshapsuhVahllcPutW...........	0	16	30	47
+9509	PF09677	TrbI_Ftype		Type-F conjugative transfer system protein (TrbI_Ftype)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents TrbI, an essential component of the F-type conjugative transfer system for plasmid DNA transfer that has been shown to be localized to the periplasm.	21.50	21.50	22.00	21.80	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.13	0.72	-4.23	11	206	2009-01-15 18:05:59	2007-05-16 16:16:43	5	2	170	0	26	141	4	108.80	52	83.32	CHANGED	++p.l.hl.hslshlslsshlohhlsp..sPslVsFDMKpTlsuFapSsupppLo-tppcshssRFsssLccpLptaptpH+slILVoPAVVpGAsDlTp-IQpslhcRhp	........................pphhhhlsus.LuhVlLNAAlSau.l...l..R.l.s..sP..l.....ssAFsMKpTVDAF.aDS.AS.Q.......KpLSEAQSKALSuR...FNoALEASLQuWQQcHHAVILVSPAVV.Q..G..A.P.DITREIQQDIARRM+.......	0	4	10	20
+9510	PF09678	Caa3_CtaG		Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.	21.80	21.80	21.90	25.60	20.70	21.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.53	0.70	-5.44	106	1028	2009-01-15 18:05:59	2007-05-16 16:22:26	5	6	749	0	353	921	395	237.70	26	56.82	CHANGED	sshYhhuhh+hppp..stths...tRsshah.hGhhslhhshsoslshhup.hhFosHMlpHhlLthlsP.LLlLG.tPhslhh...cslssttt..........hh.hhhhsthh+hlspPhlAhhlFsushahaa.hsslashshpshhhHhlhphphlluGhLFahslls.sP...stphshht+lhhlhsshshpshhGshlhhussslhssaht...............................sas.h.ssltDQplGGhlhWhsGplshllshhhlhhpWh+pc	...................................h.hhYhhu.hhth+p+....spthss....tRh...hhah..hGhssl.hhshsoslshhup.hhFShHMhpHhlLthlsPhLLlLG.tPhsLhh...pslshsht............hh....h....h..pt....hhc....h....l....spPlhAh...llFlushahha.hs.slashsh.psphsHhhhphphllsGhlaaaslls..c................Ph...spp.hshht+lhhlhsshshpshhushlhhsspslhssahp.............................hsas..h.shlpDQplGGhlhWhsu-lshlllhhhl.hhpWh+p......................	0	113	251	309
+9511	PF09679	TraQ		Type-F conjugative transfer system pilin chaperone (TraQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents TraQ, a protein that makes a specific interaction with pilin (TraA) to aid its transfer through the inner membrane during the process of F-type conjugative pilus assembly.	21.20	21.20	21.20	21.20	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.08	0.72	-4.06	4	133	2009-09-11 14:33:19	2007-05-17 10:28:23	5	3	110	0	3	55	5	89.20	81	97.41	CHANGED	MRKhRFpLPchDITGhWVhulGlaFHIVuRLVh+cP.MAhhLAElIulhhVLaGuYRlLsAWIAcsp+EE+....ARptuhhctp.-t........+	.................hpKhRFSLPRLDITGMWVFSLGVWFHIVARLVYSKPWMAFFLAELIAAILVLFGAYQVLDAWIARVSREEREALEARQQAMMEGQQEGG....HVSH..............................	1	0	0	2
+9512	PF09680	Tiny_TM_bacill		Protein of unknown function (Tiny_TM_bacill)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of hypothetical proteins, half of which are 40 residues or less in length. Members are found only in spore-forming species. A Gly-rich variable region is followed by a strongly conserved, highly hydrophobic region, predicted to form a transmembrane helix, ending with an invariant Gly. The consensus for this stretch is FALLVVFILLIIV.	20.50	20.50	20.80	20.50	19.90	19.20	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.58	0.72	-6.85	0.72	-4.52	27	936	2009-01-15 18:05:59	2007-05-17 12:31:50	5	2	143	0	116	418	0	25.00	71	52.80	CHANGED	uaGu..GFALIVVLFILLIIVGuuah	...............GhGG...GF....ALLVVLFILLIIVGASCa......	1	27	80	91
+9513	PF09681	Phage_rep_org_N		N-terminal phage replisome organiser (Phage_rep_org_N)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents the N-terminal domain of a small family of phage proteins. The protein contains a region of low-complexity sequence that reflects DNA direct repeats able to function as an origin of phage replication. The region is N-terminal to the low-complexity region.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.27	0.71	-4.54	26	638	2012-10-04 14:01:12	2007-05-17 13:57:17	5	8	478	0	41	432	20	117.60	31	43.88	CHANGED	WIKlpsshFDDcKIKll-pMs-sDslhhIWh+lllhuGKhNssGhlahscslPYTsEhLAhhhs+slssl+hALpshpphGMIEl.h-ssshplsN..ap+aQsh-sh-ppRcpscc+hp+pcp	........................WlKLppshFcDc+I+.hlcph.s.su..s..shhhIalKLllhu..hpspGt.Lhh...s...tp...lshstc.LAphhc.cshssVchslphhp....phGLlEh..h-.s.st...hhlss..ht.ph.sp.-sstsc+cRptRpppp...h..................................	0	11	34	39
+9514	PF09682	Holin_LLH		Phage holin protein (Holin_LLH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry identifies a family of putative phage holin from a number of phage and prophage regions of Gram-positive bacteria. Like other holins, it is small (about 100 amino acids) with stretches of hydrophobic sequence and is encoded adjacent to lytic enzymes.	24.80	24.80	24.80	24.80	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.23	0.72	-3.93	13	257	2009-01-15 18:05:59	2007-05-17 14:32:53	5	1	214	0	20	171	1	103.90	41	87.97	CHANGED	Msplsp.Ilssulul.lsllsGhhs+tVhcaLhKK.GGEKss+IsEIlA+sAVsAVEQlss-su.KGp-KLspA+stlpshLsphsl.phoDsplcshIEuAVKpMNssh	......................MpplsphIhssAlul...LsllsGhl....l+...sVK-YL...hpK....G...GEKsl+Is......E..ILAKsAVsAVEQlus-.suhKGcEKLspApstV+spLs+h..sI..shTDcp.l-shVEuAV+pMNDs.......................	0	5	9	12
+9515	PF09683	Lactococcin_972		Bacteriocin (Lactococcin_972)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent bacteriocins related to lactococcin. Members tend to be found in association with a seven transmembrane putative immunity protein.	22.00	22.00	22.10	23.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.50	0.72	-3.62	6	605	2009-01-15 18:05:59	2007-05-17 14:37:33	5	1	388	0	27	146	0	60.30	44	66.27	CHANGED	V-GGhWsaGlG..usasaScYhHup+sHsuTslut..s+os+uhAcAGshu+AShsK..sh.spcsFY	...................s-GGsWsYG......G..........s..th...saSsYhH.sp..+hHsSolh.....ut.....spS.sKG.hAt.AGspShAhlhs...sW.utphAFY....................	0	10	15	19
+9516	PF09684	Tail_P2_I		Phage tail protein (Tail_P2_I)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent the family of phage P2 protein I and related tail proteins from a number of temperate phage of Gram-negative bacteria.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.66	0.71	-4.62	49	1210	2009-01-15 18:05:59	2007-05-17 15:44:47	5	9	872	0	232	949	32	134.60	33	58.83	CHANGED	LPssu.osLE+slt.tshspl......tthPsslpsLhsPspCPsslLPaLAWuhSV...DpW-ssWsEpsKRpllcs.........Ah.lH++KGThuAlR+slcslGh..hclhEWapps........st.......PuTFplpltlppp.......slspphhtplpcllscuKPsp	.....................................................LPs......h.htht...tshstl.......pph..s.s.lpsL..h.s...P.s..sC.Ps...p....hL....PaLA.WsauV...........D.cW..-.p....s.W....sEpsKRpll+s.........AhhlHc+KGThuAl.Rcll-.s.......l..Gh....hlclpE.....Waphs.........................t.............tPsp..Fclpls.l.pp.......uls.pphh.plcclls-s+ssp..............................................................................	1	54	137	196
+9517	PF09685	Tic20		Tic20-like protein	TIGRFAMs, Coggill P	anon	TIGRFAMs & Jackhmmer:D3PVW8	Family	Chloroplast function requires the import of nuclear encoded proteins from the cytoplasm across the chloroplast double membrane. This is accomplished by two protein complexes, the Toc complex located at the outer membrane and the Tic complex located at the inner membrane. The Toc complex recognises specific proteins by a cleavable N-terminal sequence and is primarily responsible for translocation through the outer membrane, while the Tic complex translocates the protein through the inner membrane. This entry represents Tic20, a core member of the Tic complex. This protein is deeply embedded in the inner envelope membrane and is thought to function as a protein- conducting component of the Tic complex. This family also includes many proteins of unknown function from non-synthetic organisms.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.76	0.72	-4.07	122	1525	2009-01-15 18:05:59	2007-05-17 15:49:58	5	10	1098	0	439	1083	83	107.20	21	79.33	CHANGED	s-+ph.uhlsH....lu..................hh.uhls..PLllallp..+-p..ssalcppu+pulNFplo...hhlhs.....llssllshlh..........................................hhlsh.......llhhlh...........lht....llh..sIl....uul+A..ppGpha+.Y..Phs.lch....l	..............................p.h.uhLsa....hu..........................as..shls...Pllla...llp....ccp.........hlctpu+pu.l.hpls....hhlhs....llhh.hl.shlh..........................................hhlsh..............lhhhhh.........hlhs....hlh...sIh.......sslKs...ps........h..h..Ph......................................	0	153	304	392
+9518	PF09686	Plasmid_RAQPRD		Plasmid protein of unknown function (Plasmid_RAQPRD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry identifies a family of proteins, which are about 100 amino acids in length, including a predicted signal sequence and a perfectly conserved motif RAQPRD towards the C terminus. Members are found in the Pseudomonas putida TOL plasmid pWW0 and in cryptic plasmid regions of Salmonella enterica subsp. enterica serovar Typhi and Pseudomonas syringae DC3000. The function of these proteins are unknown.	21.10	21.10	23.40	23.90	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.77	0.72	-3.90	30	227	2009-01-15 18:05:59	2007-05-17 16:26:49	5	1	183	\N	68	210	9	80.10	40	72.02	CHANGED	uuhAs....sAuE+-pLAtslRQL-tlcths....pRApssAs.ssts...Ra+FDYsRlpsDLpplRpGIppYLsPSRAQPRD...sssLsGDY	.......s..hsssuuE+pcLuhslRQL-tlctsl....pR.A...tstAs.sssp...RaaFDYsRlpuDlpplRtGIppYLsPSR..AQPRD....sssL.sGpY................	0	7	30	54
+9519	PF09687	PRESAN	P_fal_TIGR01639; PHIST_a_b; PHIST_a_c; PRESAC; DUF3837; PRESAC;	Plasmodium RESA N-terminal	Aravind L,Coggill P	anon	TIGRFAMs, Aravind L	Domain	The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc [1] has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localise to membranes [2].	23.60	23.60	25.50	24.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.67	0.71	-4.08	162	210	2010-01-11 11:54:32	2007-05-17 16:34:49	5	7	10	0	203	264	0	125.10	16	30.63	CHANGED	phppphsccclpchlp...sltt..h...hspcchhtla.phhphp+pcahphhppLhphhpplspch.pl........sc.............chp.pchWpcspptlppphtph-pthpppFhphl..ppp...h...sttc................FhphlpphpptWcphhpphpppa	......................phpcpclpc.hlp..pltt..h...hspcchhtla.phhphp+pcahphhppLhphhppltpph....pl.........sc.............chp.pchWpcshptltpphtph-pthpp.pFhphl...ppp....h.shpc................FtphlpphpptWcphtpphppph.............	0	83	84	162
+9520	PF09688	Wx5_PLAF3D7	CHP1606_PLAF3D7; 	Protein of unknown function (Wx5_PLAF3D7)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This set of protein sequences represent a family of at least four proteins in Plasmodium falciparum (isolate 3D7). An interesting feature is five perfectly conserved Trp residues.	25.00	25.00	28.80	28.80	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.00	0.71	-4.24	8	26	2009-01-15 18:05:59	2007-05-17 16:45:06	5	1	6	0	26	33	0	139.00	23	60.31	CHANGED	acRIluE...+sp.sacp-FslthN-pp.pphpp.scpspPh..p..-pIpclspLsspsoclWK-slcsMcpcYhcpTD..pM-+pWRDtMWpp+WsK.YL-sVHspINppLN-.sholc-KEphlspWlpWsp-DacaFLphlKE-Wcc	..........................................................................t...t...pp.s......p.ht...c..hppLhhphschWcpslpsMhppYpphT-...phspcW+phMWNppWt+.YLEtlhspIspslps.shohpcpEshlpphlphspcDFphFLp.lptcWc.......	0	5	7	21
+9521	PF09689	PY_rept_46		Plasmodium yoelii repeat (PY_rept_46)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This repeat is found in the products of only 2 genes in Plasmodium yoelii, in each of these proteins it is repeated 9 times. It is found in no other organism.	20.80	20.80	22.00	20.80	19.50	18.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.41	0.72	-3.63	7	34	2009-01-15 18:05:59	2007-05-18 11:17:37	5	3	2	0	34	33	0	43.80	61	80.98	CHANGED	KSK+SRFPoMFKRDKKDK-sccu.......ts.ESLssD.....KSLEoLsDDscsp	......KSK+S+FsoMFK+DKpDK-sccu...............stSQEoLssD.....KSLEoLsDDscs.....	0	0	18	34
+9522	PF09690	PYST-C1		Plasmodium yoelii subtelomeric region (PYST-C1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This group of sequences are defined by the N-terminal domain of a paralogous family of Plasmodium yoelii genes preferentially located in the subtelomeric regions of the chromosomes. There are no obvious homologues to these genes in any other organism. The C-terminal portions of the genes that contain this domain are divergent and some contain other yoelii-specific paralogous domains such as PYST-C2 (IPR006491).	25.00	25.00	33.90	33.40	19.40	18.50	hmmbuild  --amino -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.04	0.72	-4.33	22	27	2009-01-15 18:05:59	2007-05-18 11:23:47	5	1	4	0	26	27	0	60.10	38	47.86	CHANGED	Ks.SslGN+.lRuhKcIppsNEcNsIE.KpETQLpNNNs.p.+DccDsps............KcsKcsK	......KsSslGN+.hRuhKcIspoNEKNsIE.KpETQLpNNNs.p.Ks-ccspt........cpp....t...........................	0	0	15	26
+9523	PF09691	PulS_OutS		Bacterial chaperone lipoprotein (PulS_OutS)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family.	25.00	25.00	25.70	25.50	19.90	19.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.50	0.72	-4.05	8	624	2009-01-15 18:05:59	2007-05-18 11:52:13	5	1	539	6	60	190	1	99.80	72	82.95	CHANGED	LsGCQQsssp..sPotphts........-QlpQLuoLlAGo+YLKpcCpRSDlPD-ssIh+oAlplApp+GWssts..hptLsp+ScslYpsLhcDsTPctspCupFNpphssFI-u	.....MAlCANSYALoE...............................SEAEDMADLTAVFVFLKNDCGYQNLPNu.QIRRALVFFAQQN.QWDLS..N.........YD.........TFDMKALGEDSYRDLSGIGIPVAKKCKAL..ARD.......SLSLLAY..	0	1	15	34
+9524	PF09692	Arb1		Argonaute siRNA chaperone (ARC) complex subunit Arb1	Mistry J, Wood V	anon	manual	Family	Arb1 is required for histone H3 Lys9 (H3-K9) methylation, heterochromatin, assembly and siRNA generation in fission yeast [1].	25.00	25.00	29.60	25.60	24.80	24.00	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.43	0.70	-5.62	11	86	2009-01-15 18:05:59	2007-05-18 13:22:42	5	5	74	0	72	88	0	321.70	29	75.91	CHANGED	KKKppsK..op+sKp+.PTGFEEYYsDsPlTPsEYpEEcc.lYss......RhEcsI.Rapp+RRh.-SsRpslFsKYLshGGVDsGs+hFsG...lDpcsLpshcu-pIhttpAps.l..............spcpspasVDFsuVs+GFLophhPhhhs.psp-.lphusssl+NFLsYlLhH-VCPEYpcslctAp+hCDlApcEL.p.pphttthPG-FNsAsSoLFGtshtcha..ssuWsspccDp.hhssplARp....llpFshuutst.htshca.-hsp.sshpshplps.puaEVsslphPssss+thYpph.......hssLpPlGKLluKsahsPGhst........hDhss-p.......pssssspcaEFalE-slLphCasGMKlpssVapLNsGl+aFDplhssasSFYphLsN-LMhGWKEP	.................................................h.c..ssGFEEhhs-sPhTstEhtppcp.l...Ys..........RlEpsIpRapt+R+h.pspRtplFscYh.hGGl-sus+hFpG........spppL.......pp..hstpplhthpAp...ssl..............................stpp.pasVDFpsVstGFLSphh..hhs..s.t.hphussslcNFLpYllhH-VCPE..Yp-..slhtApplCphAppEL.tspph.tt.hPGpFNhAsotLFs.s...h...t.h.....p...pta..pt......tt........thsht......hhthhhus.st..ts..ph.....phht.pphpsh.h.p..tshElhslh.Pstthpphapph........................sssltPlGphhs+shh...............Dh.stp..................tt.phphalEcslLphhhsGMKlt...sslhcLss..G..lpahcphhshhsSFashL.p-hMhtaKpP....................................................................................	0	15	31	56
+9525	PF09693	Phage_XkdX		Phage uncharacterised protein (Phage_XkdX)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry identifies a family of small (about 50 amino acid) phage proteins, found in at least 12 different phage and prophage regions of Gram-positive bacteria. In a number of these phage, the gene for this protein is found near the holin and endolysin genes.	23.50	23.50	23.50	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.73	0.72	-4.43	23	600	2009-01-15 18:05:59	2007-05-18 13:28:44	5	2	404	0	44	281	2	39.20	39	73.28	CHANGED	a-slKphYchG..haTp-pl+paVphphITtE-YccITG.ccY	................FccIKphYshs..hY.....op-.....p....lthaVsh..t..hITcEEYppITGccY..........	0	22	35	39
+9526	PF09694	Gcw_chp		Bacterial protein of unknown function (Gcw_chp)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a conserved hypothetical protein about 240 residues in length found so far in Proteobacteria including Shewanella oneidensis and Ralstonia solanacearum, usually as part of a paralogous family. The function is unknown.	20.40	20.40	20.40	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.52	0.70	-4.56	7	705	2012-10-03 17:14:37	2007-05-18 13:31:32	5	2	422	0	274	695	451	214.20	22	85.19	CHANGED	tApsuSPhohSuNluLsSpYhFRGlo.ost+PAlQGGhDhuH.SGFYsGsWsSols....ssssshu........ssEhDlYGGass..slGt..hsaDlGlhtYhYPGupsss....Y...hsEhhuuluat.l...sh+hsau.s.s.hG............pSpsstYlshssshsls.sshThhAHlGhpcst.h.ss...uasDW+lGho.+shssshshustYhDspuc.sh............u..ts.shscsshhsolstTF	..........................................hs..........ph..ous..lsh..s..SsYha.RGloQ...........o................s..s.....p.....PAl....QG..Gl....-....hua....s....u.....G.a..Yl...G.sWuS..s..l.................sh.ss.ss.........................s.hEh.DhYuG..Ypt.....ph.s.s.....hshDlG.l..h.tY.....hY.....P......us..s..............s...s..s......................................................hsE.h.h....s....s....l..u...a...s....s....h..............pht..h...s.h..sh...s...........p..h.......h..G.................................psps.s...h...Y...h.p........h.s......h.shs.....l...s..................s....h...s...l...s..s..p.h..G.........ap..p..h........p......s..................st.................sa........Dapluls......tth................s..hshsh..thhs.ss......t..t.......................................................................................................................................................................................................................................................	0	64	153	218
+9527	PF09695	YtfJ_HI0045		Bacterial protein of unknown function (YtfJ_HI0045)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These are sequences from gamma proteobacteria that are related to the E. coli protein, YtfJ.	21.70	21.70	22.10	21.80	21.10	21.60	hmmbuild  --amino -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.80	0.71	-4.90	26	1008	2012-10-03 14:45:55	2007-05-21 11:22:22	5	2	724	0	68	382	31	154.40	61	86.22	CHANGED	lplupplPsVsVs-cGELhLps..sphuYpsWsSupLsGKVRVlQaIAGRoSAKEhNusLhpAIpuApFPc-+YQTTTIlNpDDAIaGTGsFV+SShEcuK+-FPWSphVLDppGsVppAWpLppcSSAIlVlDKpG+VhFsK-GuLossElppVlsLl+p.	..................................................................h.psGppVPPVuIs-+GELlLsp..DphsYpsWNSuQLsGKVRVlQHIAGRoSAKEKNAsLIcAI....cuAp.h...PpDRYQ....TTTIVNTD.DAI.GoGh.FV+SSlEsNK+hYPWSQFllDuNG.l.u.RsAWpLs..E..cSSA..ll..VL..DKsG+VQWsKDGALTp-EVQpVlsLlpK.L.................	0	6	21	49
+9528	PF09696	Ctf8		Ctf8	Mistry J, Wood V	anon	Pfam-B_46199 (release 21.0)	Family	Ctf8 (chromosome transmissions fidelity 8) is a component of the Ctf18 RFC-like complex which is a DNA clamp loader involved in sister chromatid cohesion.	21.10	21.10	21.70	21.40	19.40	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.51	0.71	-4.33	31	267	2009-09-10 14:53:20	2007-05-21 11:57:48	5	5	235	0	194	259	0	116.80	29	75.80	CHANGED	pl.lpTPp......GhsllElQGslplPp......................ppshtssphGcLpa.............p.pptp+shLaVGppQRLhGplhKLspPLull++p.t...............................t.tpspspplcll-ll+hKl.lFKsRPhPl	.........................t.............thsllELQGplph.t..................................................ppshtsh.lGcLpa.......................pp.ppshLhlG.appLpGclh+Lp..+PluVlc+ppt..................................................t..ttpp.psphp...lssll+tKl.lF+sRPcPl...................................................................	0	64	107	165
+9529	PF09697	Porph_ging		Protein of unknown function (Porph_ging)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family of proteins of unknown function is found in Porphyromonas gingivalis (Bacteroides gingivalis).	25.00	25.00	25.30	25.00	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.45	0.72	-3.84	44	420	2009-01-15 18:05:59	2007-05-21 14:53:50	5	2	119	0	136	412	109	59.90	41	22.25	CHANGED	Wcls.pEoKpIusYpChKATssh.................................................cthslpAWYTspIPlspGPtpahGLPGLILE	...................................................................................................................Wpl.t.s-.s.+p.I.tsY.pCpKAsspa............................................................................pGRpapAWaTs-IPl.sp.GPa+atG.LPGLIl...	0	37	118	136
+9530	PF09698	GSu_C4xC__C2xCH		Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This motif occurs from three to eight times in eight different proteins of Geobacter sulfurreducens. The final CXXCH motif matches the cytochrome c family haem-binding site signature, suggesting that the sequence may be involved in haem-binding.	21.10	21.10	21.30	21.10	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.60	0.72	-3.78	135	404	2012-10-01 23:37:15	2007-05-22 11:49:07	5	30	15	0	299	381	5	36.50	38	11.69	CHANGED	oCossYCHusuts........................s.tsss...Wsssssst........C..ssCH	.oCossYCHosGpu......................ssshssPs....Wsssssst........C..suCH	0	42	180	299
+9531	PF09699	Paired_CXXCH_1		Doubled CXXCH motif (Paired_CXXCH_1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents a domain of about 41 amino acids that contains, among other motifs, two copies of the motif CXXCH associated with haem binding. This domain is predicted to be a high molecular weight c-type cytochrome and is often found in multiple copies. Members are found mostly in species of Shewanella, Geobacter, and Vibrio.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.12	0.72	-4.44	178	1252	2012-10-01 23:37:15	2007-05-22 12:40:01	5	102	240	0	748	1592	142	43.00	29	19.96	CHANGED	HsPltpu.t..CssCH......sPHuS.s..pstlL..............ptssspLChsCHspttt	............................h..ts..p.....CssCH..........................sPH...uu..s.......ptthL............................ptstsp.lC.hpCHsp...s............	0	318	549	694
+9532	PF09700	Cas_Cmr3		CRISPR-associated protein (Cas_Cmr3)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.17	0.70	-5.03	33	217	2012-10-01 21:23:39	2007-05-22 12:54:02	5	3	185	0	98	248	5	321.60	16	88.35	CHANGED	hhlpPhDslhFR-uRPFs...susps...stuhhhP.PpTlAGAlRsthhppsshph...sth.t.........................lplh.GPhlhc...........ptchhaP...tPhchhh.........hcppsshhphhtlc..........................ht.hhlsst...............tsthp.hsua.lshpslhp.aLpuch.ptp.........plhptt.............hhphEpRlGlulcspppss..........cEutLYpsp.hlRhp....................tshslulhlcsssssph...................tshhpLGGEsRhu......thch..........tth.sh.pt.ttshtpspphtl..hLhTPuhFspuh..hst..................................lsusul..s+sh....hlS.GWDh.tppcP+shp.......hh......sPsGoV...............aahchtpststtt.pttt........................tp.....hpp.GaGphlhsth	........................................................................................................................................hpPh-shhhtpspsFt.........ttt.........ht..s.h.P.spshhGhlpsh....hh.tt.t...................................................h.tlh.Gshhht..............ttphhhP...hPhshhh..................tttt...h...hp....................................h.......................tt.........t.a..hthpth......t..hhpst....t.....................ph.t................................ht.c.+htlslct..pppps...........c-..uhLaptp..hlc.ht..........................tthshshhlphttttt.........................tthhplGGEs+.hs.....tlph.................................th.p..t..htt..t........t...s.pthtl..hLlTPuh.h.p...p.sh.....hsth..............................................t....lhhhsh.....s+.h..................lu...Ga....ch....t....pp...p..s+sht..........................hh..........lssGoV...............a.hhc...h..t.t......................................t......pp.Gauhhh..............................................................	0	59	78	92
+9533	PF09701	Cas_Cmr5		CRISPR-associated protein (Cas_Cmr5)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	20.40	20.40	20.70	21.10	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.51	0.71	-3.94	25	134	2009-01-15 18:05:59	2007-05-22 12:57:38	5	1	127	7	72	132	5	120.80	23	88.87	CHANGED	Tl-QppAptAappl...................pplppt................cphpccYtshs+cLPshIhpNGLsQsLAFlhuKucpptctt...........................LhccLspaLpppst...............sllctlhpt...-hppYhthTpEsLuhLsWl+RaApuhL	.............................hppphAphAhptl...................................................................pp..htp.................pphpccYpshs+phPshIhpsGLspslAFhhuKsppptpt......................................lhppltph.....lppptt......................................slhct.l.hpt...s..tpYhhhTpcsLthhsWlKRaupuh...........................................................................	1	47	59	67
+9534	PF09702	Cas_Csa5		CRISPR-associated protein (Cas_Csa5)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry represents a minor family of Cas proteins found in various species of Sulfolobus and Pyrococcus (all archaeal). It is found with two different CRISPR loci in Sulfolobus solfataricus.	21.70	21.70	22.30	22.60	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.23	0.72	-3.95	5	26	2009-01-15 18:05:59	2007-05-22 13:02:21	5	1	25	0	13	27	0	100.10	43	74.66	CHANGED	sFlYoEoPTYVDRIuNALSKEAVs+VLaEupRIlpoGl-uGEIcttss.........sGR+....YlsV..tEK-G.sYIllGtLPSDcDVEpFLc-VERDIYhARKVGALAMAhsN+	..h.FlhoEosolVDRhANALS+EsVs+sLaDs.Rllphul-pu.EIss..h.........pG+c....Yst.s.hppp-G..chhllGhLPosp-lE.FLchlccDlhhARKsGALAholss+..............................................	0	4	4	8
+9535	PF09703	Cas_Csa4		CRISPR-associated protein (Cas_Csa4)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR loci appear to be mobile elements with a wide host range. This entry represents a protein that tends to be found near CRISPR repeats. The species range for this species, so far, is exclusively archaeal. It is found so far in only four different species, and includes two tandem genes in Pyrococcus furiosus DSM 3638. CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	25.00	25.00	97.10	96.10	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.11	0.70	-5.48	6	13	2009-01-15 18:05:59	2007-05-22 13:06:21	5	1	12	0	10	13	0	355.20	23	95.95	CHANGED	lshhhTPGas.hhDThIhYGlVcsLstuGhssu.cVhshGpcYhIps-ssspt.hp...Eplc........huLhpshEEh...HhAhhscpsp..ss+lhpstDhssGssIsss..hplahctlstpLphlpcphctu++uscuc......thsTlsLsLhPshGKYh...lcphshpEspsh+VsphsYALAhlGFaY..YushlhhpcGcsplVplhshs....sh--LshlphLs.p-Lspcl.hsthschc.hlsp.hu.LYhLhhoEol....ElsocppFsllsYsh.EpssNsptlRsFtsl-lu+lh-FlhpLKthshYcshth.+hl-pL...........h+ts.ElhtpLh-slha-..s.tuhYoslRtl......p+ushsu...c..hlsslt-hlsph	.....hhTPGHshIsDsLIhaGlVctL.stuGthcu.pl..hG-cYhlps-hsstphh....pshc.........tLhphhcEh...+hshht.psp..tshlhpshshshstshss.....sah.....cplstpLpp.lccp..hcp.t++phcuc........thhTlhLsLtPshGKYh.............lcsas..lpp.statVCshCaALAhlGahY..hoshl..phcc.....Gpp....shVplhths....sh-clshhplLslpchtppl.hhhhsp.p..lsphhA.LYhLshuEol.....hsscpshsllsYsh..p+sGNs..Qthpuhtph-ls+L.h-FlhplKt..hYcs.ph.+hl-sL...........hcc....s.EsLtsLh-slhac..p.tshYpslRpl......c+ushstp......ht.l.phh....................	0	6	8	8
+9536	PF09704	Cas_Cas5d		CRISPR-associated protein (Cas_Cas5)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.51	0.70	-4.72	102	1346	2012-10-01 21:23:39	2007-05-22 13:35:06	5	3	1181	1	402	1115	32	210.50	18	87.80	CHANGED	slhl+lhG.shtsa.upsthtspRs....ohshPohSulhGlLsush.............uh.tt...................hpsslpaslct...........pptsplhp..sh.......pssp...................................t....tttttsshls.............pttYhhcAtahlshpsssp...........................hhp.hpctlccsthhhh..LGp+ps.s.stslp..................hps...pshh.......pshpphs.......................hthhh..........................................t..st..hpchss.......hps...phphuhhpl.	.......................lhhplhG.shAsa.spsthtttRt.....oaplPohSAlhGlLuAsh...................Ghtptt...................................hp..p.hphslpt.............................spp.sp.hhp....sh.........posp............................................hh.t......t..t...phhssh..lp..............................................ptpYhh.-A....h.....ahl.sl..tsssp...........................hhlp..lpc.sl..c..c..s..h..h...hh...LGp+pp..s..s.slt...............hps......psh....................pshp.ph.............................................................................................pt.s...............t...h..u.h................................................................................................................................................................................................................................................................................	0	160	289	348
+9538	PF09706	Cas_CXXC_CXXC		CRISPR-associated protein (Cas_CXXC_CXXC)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes a conserved region of about 65 amino acids from an otherwise highly divergent protein found in a minority of CRISPR-associated protein regions. This region features two motifs of CXXC.	21.00	21.00	21.20	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.59	0.72	-3.80	10	84	2009-01-15 18:05:59	2007-05-22 14:03:33	5	2	83	0	35	86	4	64.70	28	12.16	CHANGED	cscsphsChsCGcRpspphKs.ht.h.cosh.PLhuS.ushtNaFWsspsssslCPlCpllhphsPhuhh	....................h.pctph.ChhCu...p..t..t.....hc...s...t.hshhtcss...........a.....s.sctpsahWsh.p.s.shslCslCpllatssPhGhh........	0	14	21	26
+9539	PF09707	Cas_Cas2CT1978		CRISPR-associated protein (Cas_Cas2CT1978)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	21.80	21.80	22.10	26.80	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.74	0.72	-4.04	33	643	2009-01-15 18:05:59	2007-05-22 14:09:50	5	3	629	0	107	344	9	83.70	58	72.52	CHANGED	MhVllscslPs+LRGcLuhWhlElcuGVYVG.shSs+VR-hlWpplsch....hpc.GsuVMsassss.EpGashpThGcscRtsVDhDGlhL	........MlVlVsENVPPRLRGRLAlWLLEVRAGVYVG.csSpRlREMIWpQlsph.......sss.GNsVMAWATNo.EuGFEFpTaGcNRRhPVDlDGL+L...	0	28	75	92
+9541	PF09709	Cas_Csd1		CRISPR-associated protein (Cas_Csd1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	21.20	21.20	30.00	29.90	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-13.01	0.70	-6.22	36	393	2009-01-15 18:05:59	2007-05-22 14:22:25	5	3	343	0	123	375	18	525.50	25	96.60	CHANGED	LhchYpRhtppst............lsPhua.stcpls...ahlsLstpGshls....shcptcs+cth...h.lPpst...pRo.oult..sphLhD+hsYVLGs.s...........ptttcptpt.........apuFhphlpp.hsss...p-tslp...AlhpFLcp....s..htshh..............thpp..............................p.tss.lsF+l-.ussp...hlaccsslpphWtphhssp...ps.........ps.lCLVoGcps.slAchHPshh....tspusG..ApllSFNps.uFsSaG+..p.....pupNAPlShpuuhthssALsaLlp+pppp+............plGD.sssVFWAppss............hpsshts.hshh..........tcsss................psspplpthlpphhsGhtsp.sss.....scaalLGL.usNuuRlulRaacpsshuchhc+lppaac-hthhp.t...................hhpsPt.hslhpllhuss...........+s-s.lsP..sLuucLhpuIlsGp...aPpsLlpsslpRhR...upp..............phsh.+suhl+AsLhRph+hpppt........hshuLDpspsshuYLhGRLFAlhEplQcpAl...sG..lNATItDRaauuASssPsslF.hLhcttps.HluKLtpcp.Ghhh.h..-+hlsEIhstlss...sFPsshsLspQGpFslGYYpQRpshap	..................................................LhphYpph.ttst....................l.s.ua....spppht.....hhlslspcGphhp.........hp.....h..p...tcpth...............h.lPts......pRo..osht.........sphLhDphtYhhGh.t...................................pt..pttp..ttt.................apsahphhtp.hhp......ps......t...lp.....Alhpalpp......ts.hht...................phtt....................................thhss.l...hFplp.tttt................hlhpctshpph.atphhpsp........................pst.......tt.hChloGcps...sluch.Hsshh.......tspsss.Ap..llShNt..........s..uFs.h.G+..........p.........pstsuslutpsu.thpsALpaLlpppt.ph............................plGs.tshVhWupssp..............h..p.h.....h..shh........................t..p.............................pttpph....tphhp...p..h..h..pGh.....hp..s.........tph.alluL.uss..suRlul+aahphshsphhppltpaapc.hth.t...............................htt.s...sl..hphlhtss....................pscp...h.s.......tlhtplhpullsGp...hP...slhpthltRh+.......utt................p.hs.h.+.....s.th.l..pshLh.+phph.tt.................hshsLspp....p..p.shuYlhGRLhAlhE..plpptAh......................s...hpsTht-RahsuhuspPhpsashLhphhp...ahp+.l.p.p...t...........s.....h...........h.............cc.ls-lhstls................sa...s.p..phsLp..u.tFhlGYYpQ+pthh..........................	0	51	88	107
+9542	PF09710	Trep_dent_lipo		Treponema clustered lipoprotein (Trep_dent_lipo)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of six predicted lipoproteins from a region of about 20 tandemly arranged genes in the Treponema denticola genome. Two other neighbouring genes share the lipoprotein signal peptide region but do not show more extensive homology. The function of this locus is unknown.	24.70	24.70	24.80	37.10	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.40	0.70	-5.79	4	20	2009-01-15 18:05:59	2007-05-22 14:31:14	5	1	2	0	8	20	0	282.90	34	80.84	CHANGED	sKLKLIFILhLAVLLFSC.oKElKEtpphcscV.SshhhEsK.....Esph.SKsE.spaV..............poP..E.IK.LEpK....ctat.pL+plthELDch-.lh..sYcp.sthuIDpLspQK.........NlEhI...clc+DsE.hYCK.KtsspNGtpL.YplsYcWYshtphalshsY-LLpEpNhstIs-clIcpQVHGplhphcpD.cK-chIKlFEcY.Np..............Ttl+ppchtpYsh+lLDYVKGNFTNSGYDEYhVhFhp-................ssDsEl.D.......paIccVcCFlV-psKlIKsYhIsspuuhFhPs.hppssL.t.........lpsFGhpFSQGWlADFNQNGINEIY.ltahphtsstlhhlEF.DppFVpthlhsps.-lsuVDWaKKpI..........ll+DcotsscWhc-.YQWN-s.+palL	..sKLKLIFILlLAshLFSC.SKElKEpp.EcscVEossKhE.K.........psEh.uKt...Ehspch..............cos......EtIK.L.E-K....Ktat.plp.l.hpLDhh-.hh..th.....hshs.h...p...............hphh...ch.p-tc.h.hh.ph.....t.h.Yph.hp......h.p....................................................................................................hFh....................tsph.p.........lp.lthFlh.ttphhp.Y.l......h.....t...h...............t..h..shluDhNQNGhNEIa..............h..s.hh.hEa.tt.F....l....t..h.slDW.pphh...................................................................................................................................................	0	8	8	8
+9543	PF09711	Cas_Csn2		CRISPR-associated protein (Cas_Csn2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins found only in CRISPR-containing species, near other CRISPR-associated proteins (cas). The species range so far for these proteins is pathogenic bacteria only. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats).	20.90	20.90	21.20	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.11	0.71	-4.61	5	132	2009-09-11 11:10:28	2007-05-22 15:11:46	5	1	132	12	11	105	1	185.20	44	84.50	CHANGED	lVKahYQYDEDSELKlFDcKhKSLKuSELMLVTDILGYDVNSuslLKLIHADLEsQFNEKPEVKSMIDKLsATITELIuaECLENELDLEYDEITILELIKALGVKIETQSDTIFEKhFEILQVYKYLoKKKLLVFVNSsAYLTKDElhpLpEYIsLoQhsVLFLEPR+l-GFsQYILDcDYFLIsEN	...............................................................llp.hYQYptpp-LKlF..Dtc.+sL.K.toELh.llTDlLGaDlNSsshLKLIauDLEsQ.....L.N-KPEVKSMI.-..KLsuT.IoE.L.Iu...a.E..h...LE..p.ELDLE.h.D.EITllELhKALGlKIE.Tp.S.D.T.lFE..Khh.E.IlQVa+YLoKKKLLlFlNssuYLTc-EltpLhEYIpLsplpVLFlE......s...R....c.......l.........s..h.s.Q.....YllDpDaaL..c.........................	1	2	6	9
+9544	PF09712	PHA_synth_III_E		Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents the PhaE subunit of the heterodimeric class (class III) of polymerase for poly(R)-hydroxyalkanoic acids (PHAs), carbon and energy storage polymers of many bacteria. The most common PHA is polyhydroxybutyrate but about 150 different constituent hydroxyalkanoic acids (HAs) have been identified in various species.	22.10	22.10	22.40	22.20	21.60	22.00	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.97	0.70	-5.01	10	111	2009-01-15 18:05:59	2007-05-22 15:24:40	5	1	108	0	41	130	21	237.60	22	79.03	CHANGED	sDahEhQRpYWsuWu-suR+uhu.........t.tupssssWpcul-.Whcthussusspspshh-chhcQupsaathu-phhpt..ttsttp..........LcQhtcpFuG.hp.....tssotpchsshWphPl-s.....aQphhSohpshssshhpsh........hpthppphsphLssPuLGhsREcQuQhQpLhRsth-YQpAhpcYssthsplu.cul-+htspLptshsSupsls..SsRALYDpWlcssEpuYu-hlto--YsplaGcLlNApMpL++thQphlDchhpuLshPTRpELcosp+RLpELRRcp+tLp+	..........................................................................................................t.....................................................................................................................................................hpt.h....t.t.............................t....t.h.t.a......tt..................ht...ht..s.......s.s.ht.h..............................p.h.ptt.t.hh.....p..PhhG.s+p..ptph.t.hhcs....ph.tt.ttY.t.htpsh.puhtphtpcl.ph.ppspplp..oh+thh-hWlpss-csatchhtocpFtcshGphlsuhhch....+tphpchh-phhcphshPTRuElDsltc+ltELcRcl+pl..p....................	0	13	26	35
+9545	PF09713	A_thal_3526		Plant protein 1589 of unknown function (A_thal_3526)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This plant-specific family of proteins is defined by an uncharacterised region 57 residues in length. It is found toward the N terminus of most proteins that contain it. Examples include at least several proteins from Arabidopsis thaliana and Oryza sativa. The function of the proteins are unknown.	25.00	25.00	25.00	25.50	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.70	0.72	-3.83	15	206	2009-01-15 18:05:59	2007-05-22 15:30:56	5	3	36	0	120	187	2	53.00	50	20.53	CHANGED	VQpLIE+ClphYMS+EEsspsLpcpAsIsPhhTps........................VWppLEKENtEFFcsYtp+	..............VQpLIE+CLphaMspcEslc.sLpp+.ApIcPshTph.........................................VWpcLEcENpEFF+AYhh.................	0	27	75	99
+9547	PF09715	Plasmod_dom_1		Plasmodium protein of unknown function (Plasmod_dom_1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent an uncharacterised family consisting of a small number of hypothetical proteins of the malaria parasite Plasmodium falciparum (isolate 3D7).	21.30	21.30	32.20	32.20	20.80	19.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.20	0.72	-4.04	5	9	2009-01-15 18:05:59	2007-05-22 15:47:30	5	1	1	0	9	9	0	66.30	39	31.54	CHANGED	oFFKRAKLlL-sFDNIFIDKLIDuNIpNKuSsl+EDVh-NuLsLssAsI.hhAIPIaoYlsKRINFF	SFFKKhKLlhshhDsla.DhLIssslpstu....EhV..ssLuhhsushP.huhshhsYlspRINFh	0	9	9	9
+9548	PF09716	ETRAMP		Malarial early transcribed membrane protein (ETRAMP)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homologue from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.	25.00	25.00	25.50	25.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.90	0.72	-4.03	32	90	2009-01-15 18:05:59	2007-05-22 16:41:14	5	5	16	0	54	94	4	83.20	24	37.35	CHANGED	MKlsKl.hhhhshLLulpll.............................................sPsh.ssss.tspss.................................+thtphpsshp+K...hcppKhhllSoluoslAl..llusul.GhuhYpppKpp	..............................................MKlsph.hhhhhhlhh.hphh......................................................................ssh.spts.t.tppts........................................tslcphc.pslpcK...h+pcKhllloo..luoslsl..llussl.GlshYhp+Kp.s......	0	13	25	44
+9549	PF09717	CPW_WPC		Plasmodium falciparum domain of unknown function (CPW_WPC)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This group of sequences is defined by a domain of about 61 residues in length with six well-conserved cysteine residues and six well-conserved aromatic sites. The domain can be found in tandem repeats, and is known so far only in Plasmodium falciparum. It is named for motifs of CPxxW and (less well conserved) WPC. Its function is unknown.	21.10	21.10	22.50	21.90	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.83	0.72	-3.35	72	270	2009-01-15 18:05:59	2007-05-22 16:49:37	5	9	13	0	270	301	4	60.40	28	48.96	CHANGED	Cp.....cs.Ysp..CPtsWh...........tspst.....Chus..ssY....pGs..Cpphh.pFpp.hspppKppauppCplpWPChp	.......................ps.Ys.....t..CP..hsWh................hspsh............Chus...psY.................pGs..Cpp.....hh..shps..h..s.pppKpp.....apppCplpWPC...................	0	84	120	223
+9550	PF09718	Tape_meas_lam_C		Lambda phage tail tape-measure protein (Tape_meas_lam_C)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This represents a relatively well-conserved region near the C terminus of the tape measure protein of a lambda and related phage. The protein, which controls phage tail length, is typically about 1000 residues in length. Both low-complexity sequence and insertion/deletion events appear common in this family. Mutational studies suggest a ruler or template role in the determination of phage tail length. Similar behaviour is attributed to proteins from distantly related or unrelated families in other phage.	21.80	21.80	21.80	22.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.26	0.72	-4.07	62	1382	2009-01-15 18:05:59	2007-05-22 16:53:26	5	11	585	0	77	1312	114	76.70	38	9.36	CHANGED	pusWhsGs.ppuhtsah-sApssuup...spphhosAFsuhpsulssFlsTGKhsFcs...........assSlluDlu+lssptuhssslsu	.......................pGsWhsGl.ppGaupat-sA.sD....shuQ...scsssTpsFsGh....up....shAshlT...such...s...aRu...........F...T.pSVLu.hocIlh+tAhlshlt...............................	0	15	38	57
+9551	PF09719	C_GCAxxG_C_C		Putative redox-active protein (C_GCAxxG_C_C)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.	21.30	21.30	21.30	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.30	81	793	2009-01-15 18:05:59	2007-05-23 10:44:21	5	8	499	4	237	679	25	120.90	26	77.02	CHANGED	asCupulltuhs-phuhs.ss....sl+huuuFGuGhG...sGssCGAloGuhhslGh..................hhGcsp...............ttttppchhthsp-lhctF+....ccaG..uhpCcpLhtt..................tt..tpppCsplltpssc.hlt-hL	................................asCupulltsh....s....-ph...shsh..pp.....shchuuuF...u.uGhG..tht.ssCGAloGuhhslGh..............................hhGcsp.......................ttttptpshthsp..........-lt.p..p.Fc......................pc...hG.....ohhCppLhst............................tp..ttppCsphltpsschhtchl............................................	0	118	214	231
+9552	PF09720	Unstab_antitox	Stabl_TIGR02574; 	Putative addiction module component	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry defines several short bacterial proteins, typically about 75 amino acids long, which are always found as part of a pair (at least) of small genes. The other protein in the pair always belongs to a family of plasmid stabilisation proteins (IPR007712). It is likely that this protein and its partner comprise some form of addiction module - a pair of genes consisting of a stable toxin and an unstable antitoxin which mediate programmed cell death - although these gene-pairs are usually found on the bacterial main chromosome.	22.40	22.40	22.40	22.40	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.32	0.72	-4.28	83	291	2009-01-15 18:05:59	2007-05-23 14:36:35	5	3	140	0	122	319	88	54.20	24	70.64	CHANGED	pLsspERlpLl-pLhcSLsp...s.ps..c.lsphatpElccRhpthcsGpspslsh--lh	...........................pLs.pERhtLs-pLh.cSLst....s.ps..........p.lsphatpEhccRhpphcsGpsp.slsh--lh.......................	0	43	74	117
+9553	PF09721	Exosortase_EpsH		Transmembrane exosortase (Exosortase_EpsH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are designated exosortase, analogous to sortase in cell wall sorting mediated by LPXTG domains in Gram-positive bacteria. The phylogenetic distribution of the proteins in this entry is nearly perfectly correlated with the distribution of the proteins having the PEP-CTERM anchor motif, IPR013424. Members of this entry are integral membrane proteins with eight predicted transmembrane helices in common. Some members of this family have long trailing sequences past the region described by this model. This model does not include the region of the first predicted transmembrane region. The best characterised member is EpsH of Methylobacillus sp. 12S, where it is part of a locus associated with biosynthesis of the exopolysaccharide methanol-an.	25.30	25.30	25.30	25.40	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.97	0.70	-5.18	102	524	2009-01-15 18:05:59	2007-05-23 14:54:15	5	4	392	0	259	557	185	236.50	17	69.36	CHANGED	hlhshhlhh....ah..h.t.........hhttW..hp.s.....tphsHuhllhslsha.lhatpp.t.h...tt...ts..h....ulhhlhhuh..hhalhuph.......sth.hhhtthuhshhlhuhhhhhh...............Ghphhp............th......hhPlh.hllhhlPhs..thl......hs.hs.sLpthsuphsshhLphhGhslhh......c..........Gshl.....hlsstp....lpVspACSGlchlhshhsluslhshh..hptshhp.+hhhlhsul.slsllsNhl....Rlhhlsl.ls...hhs.........................phu..tshhHthhGhlhFssshhhlh.hlsthhtph	.........................................................................hh................................h........................h.hh..h.hh...hhh.......h.....................................shhhhhhhh.....hh.hhht.................................h..hsh.h.hhh..hshhhhhh...........................Ghthht................................hh.........hhslh.hhh.hh..l.Ph........h............h...h.h.....sLpths...uthss..hl..l.p..hh..G.....h..s...shh.......p................................Gshl.....hl.s.stp.......lpVst..uCoGlph.lhhhhulshhhh.h........h.tshhc...+l...h.h....hhh.ul....slsh....hsNhl....Rlhhlsh..ls......hhs...............................phh....hshh..H.p.h.h..G..hlhahhhh.hhlh.hhh......hh......................................	0	88	205	245
+9554	PF09722	DUF2384	CHP2293; 	Protein of unknown function (DUF2384)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. The function is unknown.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.39	0.72	-4.11	120	1010	2009-01-15 18:05:59	2007-05-23 17:01:51	5	9	668	0	338	835	106	54.10	24	37.91	CHANGED	hppspsla.Gsp..........ptAppWLp.pPshu..LsGppPl-llp.o..ttGhptVtphLspl.ctGl	...............................................h...h..lh.sst..........ptA.tpWlp..pPstu..LsGppPl-llt..s....suhhtVhphLsthctG...................	0	84	192	261
+9555	PF09723	Zn-ribbon_8	CxxC_CxxC_SSSS;	Zinc ribbon domain	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.56	0.72	-4.00	182	1432	2012-10-03 10:42:43	2007-05-23 17:08:51	5	3	985	0	622	1298	568	41.50	36	43.22	CHANGED	MPlY-YpCp..pC..GppFEhlpphu-..ss.ssCPpCuu..p..hp+hlS	...MPhYcYp.......Cp..sC..GppF-h.l.p.p...hu-......sshssCP..pCuu..phc+lh...................	0	254	465	555
+9556	PF09724	DUF2036		Uncharacterized conserved protein (DUF2036)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG0798)	Family	This family of proteins includes members ranging in size from approximately 300 to 460 residues. There are a number of well-conserved domains along the length.	20.50	20.50	21.30	20.60	19.10	19.80	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.01	0.70	-5.29	22	306	2009-09-11 06:41:13	2007-06-15 09:23:13	4	5	268	0	216	306	2	281.80	22	80.09	CHANGED	sYpLLplsscllcplc......pu....p..sLtl+Gt..................s-cu..VLCocs+TaslKthcpSNolLLh.thh.s..................................p..tst....phphhshspphhElpp..h.psphcplcp..lthshasG..cstt..ch.t.............ashcpLlsssQsScpEhpptLpp.lsuhpl-.GthplLs.cahh+hLshllthlsspuhsh..s....clshpsshpslt.s...........hsppllcsslpha....upp.s-..................hapLctpplsphhuhtlLpphh.........phplc-...........Fh.pWppplP.......shshchchLcGhsllp...........pstsp...plphls.psL.Ppshp-RFppLFph+p.cWsh--lpPaIc	...............................................................................................hpLlcL.ssplhp.lp......................ps.........p.........pLhl+ut.........................................................s.-ps......VLCops.cTapl+tspp..SNslllh..h..stt................................................................t...............thphhuhh.pphhElpp.......h....tsphp...tlt.h..h..s.apu..p........ptt.p.t......................................................hshppLhpph.sSptEh.pthp.p...htu...h.............h......p....G......h................hp.h.lp.ph.hphl..phlht.h.t.ps...hth..p.....................p.hshpphhptlt....................................................spthhpth.l.p.ha........sp...t................................................................t.........hhplptptl...sphhu..h.Lpth......................ththp-..........................Fht.Wppt.lPt...............th.sp.hp....Lp.Ghhh................................................t.st.t..hl.hh..ppL.s..p.....ttRht.LFphp..pWp.t-htPal...................................................................	0	74	121	178
+9557	PF09725	Fra10Ac1		Folate-sensitive fragile site protein Fra10Ac1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1297)	Family	This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved protein, of unknown function that is nuclear and highly expressed in brain [1].	20.90	20.90	21.50	26.10	19.20	18.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.75	0.71	-4.01	11	188	2009-01-15 18:05:59	2007-06-15 10:13:15	4	8	151	0	128	192	2	114.90	55	41.83	CHANGED	+TDhDlLKccH+Fl+D----sc.........sWtcpLA+KYY-KLaKEYsIhDLS+Y......+csKl....................GhRWRTEsEVlsGKGphhCGs++C.....................................................pcspsLcoaElsFsYhEpGccKsuLVKlRlC.cCuhKLNY	.......................................+TDhDll+EsHRFlhs-E..-.-...-.......................oWEpRLAK+YYDKLFKEYCIADLS+.Y......K-sKh....................GhRWRsEcEVlsGKGQFhCGN++.C..........................................................................................................s.c..c-sL+SaEVNFuYhE.cGEp+sALVKlRLC.cCohKLNa....................................	0	58	75	104
+9558	PF09726	Macoilin		Transmembrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1821)	Family	This entry is a highly conserved protein present in eukaryotes.	32.00	32.00	32.40	32.70	31.60	31.20	hmmbuild  -o /dev/null HMM SEED	697	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.29	0.70	-6.25	5	207	2009-01-15 18:05:59	2007-06-15 10:14:40	4	6	88	0	126	181	0	441.60	33	90.48	CHANGED	KRRNs-CGK..RRPlKRs.KhAEGlsuSTFLYIKFLllWshVLLADFlLEFRFEYLWPFWLLIRSVYDSFKYQGLAFSVFFVCIAlTSDlICLLFIPlQWLFFAASTYVWVQYVWHTDKGICLPTVSLWILFVYIEAAIRaKDLKN.PH.lDLCRPFAAHCIGYPVVTLGFGFKSYVSYRhRLRKQREVQKEN-FYMQLLQQALPKE..s+sLpss-KEsoEsoocuhToscsllsspsstssssssKlSs.shsplthp-pupcptp...sssppp+slupsNs...pspsl.......suslQ-lEhhps+oNuS+hoss.hsGsspshsh+cc......opuSSssptossSKsSsosptstts.uNSSP+SHsss.............................................................................................................NGSVsSSSsscN.........-cKpKpuupssutth..c..h...ssscsVcsshssNp...lSoPsAls.....................RLEsDIKKL+AELssuRQsEsELRsQIS.LoStERShKS-LsQL+KENDhLQTKlpuhVSuKQKDKQolQolEKRLKuEp-uRsslEKQLsEEKKRKKpEE-TAARAsA.AtsoRt.EsuESLKp+K+DLEsEIcKLpp-lKlKEEppcsLEKcs....QEl+KY......+E.SpK-TEVLMSALuAMQDKNppLENSLSAETRlKLDLFSALGDsKRQLEIApGuIapREpEIlDLKuKIA-llAVMPs.shu...SplpssTPHYSupFL-ssPuutsosuSsY.sL	..........................................................................................................................................................................................................................................................hh.hDhhh.hRhEhhaPhWhhhtshhpohphp............sl.......h.........hshhFhhhshh.shhChhhlPhphlhhhuoshVhhthhhp..s...........ptG.......................................husH.lGas.h.hsh.hp.hht...hh.phphtltttN..hhp.h.puLP..................................................................................................................................................................................................t...............t..........t.................................................................................................................tt...t...t....t............................................................................................................................................tts.........s.s.s.....p................ppt.ttt................................tt...t.........t.t...........................................................................................p...Lct-lcc..h+s-lpt.+p.Ep-h+tp..............h.s.tth..t.+.phtthptcs-........lpp..........+htph.p.+pt-+.shtthE++.......l......ttEtct+..........h-tpL.pp+pt+h...........tt.........t.....................................................ptsp.......h..+tc..pph-...t-hpplphchp.t-pth..h..ch......................................ttht.............................pc.......t.-.-hLhtsLtshp-Ks.pLEpsLuuEsRlK.-LFpsLGts++phc..t..................................................................................................................................................................................	0	47	58	97
+9559	PF09727	CortBP2		Cortactin-binding protein-2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1103)	Family	This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans.  The human protein has six associated ankyrin repeat domains Pfam:PF00023 towards the C-terminus which act as protein-protein interaction domains [1].	25.00	25.00	27.50	27.00	22.90	23.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.28	0.71	-4.80	8	414	2009-01-15 18:05:59	2007-06-15 10:15:04	4	12	99	0	190	349	0	128.90	39	16.96	CHANGED	suc+Epcs-sLSKc-LhhLLSlMEGELQARD-VIchLKA-Rp-lhl.EApYGphs.pcPhtALQRDuhtuuucsppccl...YpsPlupL-+lht+pKcoQcRMhsQLlsAE+pp++hlhcL-t-+ct+hcahppuD-hhshLEpctp..Lp..LE.EKupppptEpE+cKhss+Lc-EhsKhKShsLMLVcEppph	..................................phsp.-Lh.LhuhhEGElpAR..-.VIthL.+..........sp+hc..l..Et.YG..h.p..........p......csh.uLpRDh.....................h..t.......t....t......................t.p..sl....................hppPhs.Lchl.tpp+ph.cRh.tQLhhuEppp+p.......................................................p..p...lE.E+...tthEpEppKh.tpLc-Ehs...+.KphshhLltEpp......................	0	20	35	91
+9560	PF09728	Taxilin		Myosin-like coiled-coil protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1850)	Family	Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells [1]. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localises to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription [2].	27.40	27.40	27.80	27.40	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.12	0.70	-5.34	18	400	2009-01-15 18:05:59	2007-06-15 10:17:26	4	7	207	0	247	384	2	263.30	35	60.93	CHANGED	+chsKtsp.LhpsLsphss.t-KlptlhK+hsEhlp-p+php+phphhpK+hptlp+EK-plpsEps...Kshhs+sKLEsLCRELQ+cN.+pLK...........EEshpptcEE-c+RpEhsp+FQssLpDIQsph-ppsscspc...Lpc-NpcLscKlKpll-QYE...........lREpph-+lhKp+-LphQLs-AKLpptppthppppp+pcppp-hhhpph.....plpphpcpEppL+.........................pQLslYs-KFc-FQsoLsKSN-lFsTFKpEMEKMoKKhK+LEKEstsa+s+aEpsNpsll-MsEE+ph.......pp+chcphpp+lp+LEpLCRuLQsER	..............................................................................t...t+....l.p.l.s....p....hps....p+lt....hl.h.K+hs-Llp-h+p.....p+p.hp.hhp..K+ttpl.p-+cp........l.puEhs....................+sl...hs+sKLEsLCRELQ+cN.+pl..K...........................-Eshph....scc-ccpRpEh...ss+F...pssLp................-Ipsph-..ppspc...shc..............hp-..N.t........Lt.....pKLKplh-QY-...........................lR.EpHhcc..lh.+...p+-L.p.pLhpAKlpptpph.hcptpp+ppp.pp......................................psp.hpppEspL+....................................................t.QLslYs-KFc.p...........hp.....sTLsKSNElFtoF+pEM-cMoKKhK+LEKEshhh+p+aEpsNt.......sllphhEE+ph...........................ppcchcthphchp+LEpLCRthQtpt....................................................	0	73	114	174
+9561	PF09729	Gti1_Pac2		Gti1/Pac2 family	COGs, Finn RD, Bateman A	anon	COGs (COG5037)	Family	In S. pombe the gti1 protein promotes the onset of gluconate uptake upon glucose starvation [1]. In S. pombe the Pac2 protein controls the onset of sexual development, by inhibiting the expression of ste11, in a pathway that is independent of the cAMP cascade [2].	20.40	20.40	22.00	20.80	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.12	0.71	-4.38	32	332	2009-01-15 18:05:59	2007-06-15 15:36:41	4	3	138	0	260	349	0	134.00	35	33.49	CHANGED	Ta.pGalcospDALllhcAshp.......GhLs..plsRR.p-cERs.hIpSGsVFVapEppoGhKRWTDGhsWSPSRl..GpFLlYRELsKpp...........................t...tttt...ps...tt.tp.s.h..........................................................................................................................................................pshtaK.sG...LlKKThSlpsp.......................tspphHlISYYsh	...........................................oa.GalpostDAlllhcA.sh............GhL...pltRR.p-pERt.hIpSGsVFVa..pE.............p.........p..u..........Gh+RWTDGhsWSsS.Rl...G.s.FLhYREh-tth..............................................................................................................................................................................................................................................................................................t...h.h+.sG..LhKpohSlphp..................phHllSYYt.h...........................................................................................................................................	1	105	173	236
+9562	PF09730	BicD		Microtubule-associated protein Bicaudal-D	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG0999)	Family	BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta Pfam:PF05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells [1].	26.00	26.00	26.30	27.10	25.40	25.90	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.61	0.70	-13.47	0.70	-6.18	11	255	2009-01-15 18:05:59	2007-06-19 14:23:25	4	5	95	0	150	256	0	528.20	44	84.39	CHANGED	upuhSsp++sAtDGEopEEoLLQESAuKEuhYtt+lLELQsELKQsRshlsNspuENERLsslsp-l+-s.................spslElpRsRhR-ElKEYKhREsRLLQDYoELEEENISLQKQVSsL+psQVEFEGLKHEI+RLEEEsElLNSQLE-AhRLK-IAE+QLEEALEoLKsEREQKssLR+ELspahshssh..hushplpl-tl..phpc-.ptsspss...........sDs-ch.sut.pss..ht.................phtsstpuElh..sPssu.....VsDLhSELplSElQKLKQQLhQhEREKssLhusLpEsQpQLcpupsslsEpp-+VspLTpplsAl+p.............................ttKctpss.-ppcspsspcs...st.aElDhpu.ElLpCKh+sAlsEhscL....+pELKsL+scapphpp..php--+s+hcs-lQsLscclpphE+su+pc.tc..........................chucLEpElpthsclAsEopGsLssAQDELVsFSEELApLYHHVChsNNETPsRVhLDaY+cuthhtt.t......st..scth.sshh.phhh.........tEs.t...t.....................spuPussu.osshSPs............tDhR..p-PhNIhNLlAlIRDQIKHLQpAVDRohpLuRQRsA....utcLushsD+DpEuhhEEILKLKSLLSTKREQIATLRsVLKANKQ......TAElALuNLKSKYEsEKuMVoETMhKLRNELKuLKEDAATFSSLRAMFAoRCDEYVTQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEh	........................................p..o.p+hsstsG.ppE-sLlpEoAs+Et.h.tplh-hps-l+p...+t.htpspsEt-Rh.t..pchtc..................pp.hEhpRhph...+s-l+EhKhREsRLLpDYoELEEENIoLQK.VSsL+ps.......Q......VEaE....GlKHEl+RhpEEs.hLpuQlE-hhcLKcIuE+QLEEALEsLpsEREpK.sL+KELsphhshps........s..phth..sl...pth.....tpp..........p...........s-.t...tsh.t............................t...pst.h...P........hsDLhSElplsElpKLcpQL.Qh.E.pEKs.LhtsL...............p-sQppLcpspstLp..p..pclttLs.t.p.lpuhpt.................................t.p...ts.....-ttpttsttpp................c...L...ts+hp.suhs-hhpL....ptclcsL+tphpt..t...pht-.pp..s..........phcschp.hppplt.h...Ect.p.p.tt...........................thtphcp-LpthsphAsEspspLssAQ-ELlshSEELApLYHHVChsN...sET.PsR.V..hLDah+psps.htt.........................p.pt..h...s.sh...t.h..................................t........................ptt.p.s.p....s...ush.......................tD.p...p-sh.....slhsh.shlpDQI+H.Lpt.AV-+ohplu+p+hs........s.phssh.cc-tEth.Epll.KLKSLLSTKREQIsTLRsVLKuNKQ......TAE..lALuNLKsKYEsEKshVoETMhKLRNELKsLKEDAATFSSLRAMFAs..RC-EYlTQ............lDEhQRQLsAAE-.......EKKTLNpLLRhAIQQKLALTQRLEpLEh......................................................................................	0	43	60	108
+9563	PF09731	Mitofilin		Mitochondrial inner membrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1854)	Family	Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex [1]. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain.  In addition, it has three centrally located coiled coil domains [2].	27.40	27.40	27.50	27.80	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.81	0.70	-5.86	33	516	2009-01-15 18:05:59	2007-06-19 14:34:14	4	7	348	0	280	469	33	425.10	19	80.05	CHANGED	pssht+...hlhhhsLhsslsaGGslhhuphs-cFp-hhpct.lPhu......Ecllphh-pts.......................htt...phhpth.t...............................................sshspcstsspppssshttpss....................................t.pphtpshcthtpphlppstpthttst..........p.hpttsp.h..........................................................................................t......................h.tht.hssssstl..pplhshhscllsslsspsh...tschsshlscsppplsplspclsclppphcpclppplcppppc.hpphspphhtphctt.t..p.ppphppchppccpclccphcpcLcpcLcppppshpp+lpstlt.tplEhp+pFpc.lcc+lppER...........sGRLupLscLpup.lpsLEphstu.......hspshspscpsppLthulpulcusLcsuss.........pPlppclssLpch............................usc.............Dpllssulsulsstuhpc...GlhopspLhsRF.ppltsclR+sSLl..PssAGlhuHhsShlhStllFc.Kp....s.........supDl-olLuRscphLccG-LDtAsc-hss.L+G.Wu+...........cLApDWls-uR+pLElcphlcllpu-up	..........................................................................................................................................................................................................................t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t........................th.......t......................h.th..t..th.t.t..t...p....................t.t...ltt...................t.........t.t...............................t...p....tt.h............t.tt.h.pt.php......httttt..........tt.htp........t.t...........tt.h...t..pp......................tthh.pl.tph.sp.l................ptlpp....hhtt.................hs.......pt..s.phptlhhuspu..l.ptslppu......................hshtttlpslpt..........................................ssp.........s.hht......shltuls......uhpt...Gl.o.tpLhs+........F..tltp....hpps.uhl....tp.....sulhthhhuhl...Sh.lhhp...tt................................s..............ps.s....s..sllscsphhlp.pGcLc.Ahc.hsp.LpG..u+............tlu...p...-WlppsRhhl-spphhphl.t...............................................................................................................................................................................................	0	93	156	236
+9564	PF09732	CactinC_cactus	Cactin; 	Cactus-binding C-terminus of cactin protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2370)	Domain	CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo [1]. Most members of the family also have a Cactin_mid domain Pfam:PF10312 further upstream.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.77	0.71	-4.53	19	306	2009-01-15 18:05:59	2007-06-19 14:37:51	4	10	240	0	225	312	5	124.40	58	22.10	CHANGED	hscchcs...+KP+aFNRV+oGa-WNKYNpTHYD.h-NPPPKhVQGYKFNIFYP-L...hspsp..sPpYplps..........sts.ss-hsll+FpuG.....................PPYcDIAF+IVs+E...W-asp+t...GF+ssFcp..............G.lLpLaFsF..........K+hpYRR	.............................Wt-KYRPRKPRYFNRV+TGaEWNKYNQTHYD.hDN.PPPKlVQGYKFNIFYPDL...IDKsp..sPpYplpp......................sss..scDhsllRFpAG.....................PPYEDIAF+IVs+E...W-YStK+...GF+s.p.F.c.p.G..Ihp..LaFpFK+hhYR+........................................	1	87	133	186
+9565	PF09733	VEFS-Box		VEFS-Box of polycomb protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2350)	Family	The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterised by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain [1]. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression [2].	21.10	21.10	22.40	21.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.71	0.71	-4.53	11	298	2009-01-15 18:05:59	2007-06-19 15:00:15	4	4	186	0	137	263	2	114.50	39	22.98	CHANGED	tcclsuEpscsRshhh.h+pRpFaHScpsQPhphcpl.SDpDSEDEsD..c-hhchc-pphL--FsDVsc.sEKclM+LWN.FV+KQpllADuHlPWACEuFs+hHGp-Llps.sLhhsap......lahIcLasaGLlsucohspssphL	...................................................h..pp.h.........p.DS-sE.D..st.hhp.cp..hp.lp-FsDVsc.sEKElM+hWNha....V...h..K....p......s....h.....luDsp...lPhACphFlp.h...+GpcLlc+..s...LhRsFh......LHhssLa..DauLlsshsl.pssph...............................	0	42	73	107
+9566	PF09734	Tau95		RNA polymerase III transcription factor (TF)IIIC subunit	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2473)	Family	TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.	27.70	27.70	27.90	28.10	26.60	27.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.23	0.70	-5.10	52	385	2009-01-15 18:05:59	2007-06-19 15:02:08	4	9	291	0	250	378	2	276.50	25	54.86	CHANGED	clsslEhPthV....psls+..................ulpslGG.ptlsp.....................slpstptp............................................................................................................................................lcLph.....p................spDsh..s+Pl..husp.....p.ssslLL+lsh...++stptpp....t................................................................hpschlGhlspsapFc...shuDFpahs......s..htp.........chppphhsh................pthp.hp.p.s..............................................................................................................................................................................................................................................hpl.......hPP....................................................................shFSphch.PasYt..................Ycpsstspt......................................................................................................................................................................................ttsp.t..........hsspppttphththhshs.hs.lPsp........................th.t.tthp.h.pptlphlcpLF-cRPlWs+psLh..splsp........pphtlK...............pslshluYhapsGPWRpshl+aGaDPRpcsp.thYQol.FR	...........................................................................................................................................................hhslchPhhl....ps.sp..................hltshGG.ttlpp..................................................hhtt.t..............................................................................................................................tlpLhh..p.....................spssh....s+Ph...hupp.......h.spsll..L+lph...+ppt...t......................................................................................................................................thphchlGhlsphapFp.................shsDFpahs................tp....phttphhth..................................h..h.t..t.........t..........................................................................................................................................................................................................................................h.h.....lPP..............................................................................................................................................................................................shFophsh.Phpah..................ac.ps..p...........................................................................................................................................................................................tt...........................h.h..thpp..tt........h.h.h...............s.hPpp......................................thp.h...p.ph..t.lp..p..LF-.....pRPlWo+pulhspls.............p.ptl..K.......................................................hhlshluYhhh.s.GPWRphhl+aGaDPR...p...ss.ps+hYQsl.FR................................................................................................................................	0	91	143	211
+9567	PF09735	Nckap1		Membrane-associated apoptosis protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1917)	Family	Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease [1]. It is involved in the regulation of actin polymerisation in the brain as part of a WAVE2 signalling complex [2].	20.10	20.10	20.10	20.70	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	1117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.88	0.70	-13.74	0.70	-7.09	8	304	2009-01-15 18:05:59	2007-06-19 15:03:46	4	9	127	1	181	296	1	741.10	36	92.42	CHANGED	spQpKlAEKLsILN-RG.GhLsRlYNIKKsCuDsKs+PsFLs-KshEsulKaIl+KFPslDs+ss..pLsslpcppsEIl+uLu.YYaoFVDlhEF+Dplh-LLsTlDusQlahDIslNaDlT+uYLDLlVTaVolhlLLSRlEDRKslLGlYNtAHEMpHGpSDsuF.sRLGQMIl-YDpPLKKLpE-FsPHo+tlosALpSLphlahRRNpou-pWRssQlLSLlusP.uslLssupo-ThACEYLSl-sh-RWIlhGallCHspL.ssssl.clWplALQsuLsloLFRDE.............................slhlHcshpshlpuhKGYuKRluD......................l+Es+EpAlupuuslH+ERRpaLRsAl+ELsLlLsDQPGLLGPKhLhVFhALuhARDEVlWLlRHsspss..pp+s+o...sEDhsDspIuELLFhMEcLRuLVRKYhuVlQRYalQYLSuaDAlsLspllQslulCsEDESlILoSF....lspLsSLssKQVEssEhF..DFouLRLDWFRLQAaTSsu+SulpLpcpc-.........LuchMNshVFHoKhVDpL-EhLsEsSDLShaCFYs+hhEchFtpsLEtP.upsRYsIAFPLlCuHFspCsH-hCPEE+s+Isc+uLuhsNpFLEEhAKpscslIsplCuE..ptsLupQLLPcHsA.+hloputscKspt..sps+KG.ts-hptPGtESaRKsRpslTshDKLphsLTELChulNas.slsVaEHsFsPREYLsspLEs+Fs+ulVuMstY.s.ssp-lsRPSElLuul+AYMollQolEpalulDloRlhpslLLQQT............QPtD.SpGcsTIsslYTNWYL-sLLRcsSsGsIVauPshpAFlShssE.thsFpAEEaSDlsELRALuELlGPYGhKhLsEpLMWHluSQVsELKKLVspN+DlLhtlRosFcKP-pMt..ull+pLs.............ssDsVLpRMhIIG.ILoFRsLhQEALccVLcp+lPFLhSsIcslp-plP.sssDhKshhpltElASAAGlsCclDPuLVsAltupKuc...spE.-acsuCLLLVFVAVSlPpLAtsssStYssph-GasNNlHCLA+AIsslsuA...............................LFol.tpssIEo+hKEFLsLASSSLLclGpEoDKsp......l+sREolhLLLD.lVpcSPaLThDhLESCFPYsLLRNAY+pVYcpsh	......................................................................................................................................................................................t...p...thh...s.h.........th..h.......t.t.t.hht.ht.ah..hhD.hh.hp..-thhphl.thts.......h.h..t.s..hh..ahpLhh.hh...th.hh.tp........c.+hlhthashha....h.ptt.-..th..+...................hsphh..h.p.....Ph+.hh.pch.......ht.......h....t....hl.uh..hh....t.p...p.h+t.thhs.ht......hh.ss.t...h...........h.....hh..h.t.h.pWhhh......shhh..t.h..t.................p..........h....hh..sLpts.hl.lh+-p..........................................................................hh.hHp..p..hh.s...h...h......sK..chtc...................................................lp....-.hp.sh..pss.hHtp...+R.hl.+.tltph..hht...cpPsLLuPp.....h......hh.h.uLsh.psEl.WhhpH.t......................t...........-..-....pls.Ll.hhtplpthltca..hhp.t.....Yhl..................palst.ss..lp.hht.s.........th.h..s.....-.shhh.psh....hp.ht..tls...p...........pp....................phpshRh.cWhpl...hhho.spsshtl.tc..p.......................lhp.hs.hh.aophl.Dth.p.L.cpusL.ph.hh.......aa..p..hp...t.Ft.....s.h..s..s..pa.hsa.hlsspF..psh.p...hs.PE.E................h.t...ltpculthsp.hl-phhtthpshl....lssc.....hthttp.LhPppsA...h...tt...th...............tt.....h....h.PG.E.Sh..csp...lp.h-thh.tLspLs.shs.h.sh.Vh.pashh.pEYhpppl..pht...c.lh.hh..............h....h.........s.tpl..........+PS.l.s.lptahshlp.htpalthDhophhppsLLpps.............................p.h-.tpst.ohsthhspWY.-sll+psS.......sstlhh....psF......hsh..............sa.s.-paoDhpEhpuLsclhGsYGhchLsctLh.Hhss.l.plcphlh..pNh-hL..th..tsshpps-.ht....t.h.p.l...............sh-sllphhh..hG.hlsF+thht-uh.tlhp.phPhlhu.ltsh.p.hs....s.h.p.........h.p.husssGl...sc.h.Dsths.sl.t.hst..........................t..hshhLh...al.hsuh.h.s.......o..ap.thtuatNNhHChsh...s...l.tl.su................................h.ph...........pt..s..hp..pth.....p..Flhhuu..lLp.....pp.p...p............................h.p..........lhhc.hhp.s.hls.s.hE.hhPashhpt....h....h.......................................	0	66	98	139
+9568	PF09736	Bud13	DUF2050; 	Pre-mRNA-splicing factor of RES complex	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2654)	Family	This entry is characterised by proteins with alternating conserved and low-complexity regions. Bud13 together with Snu17p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex. called The RES complex, pre-mRNA retention and splicing complex. Subunits of this complex are not essential for viability of yeasts but they are required for efficient splicing in vitro and in vivo. Furthermore, inactivation of this complex causes pre-mRNA leakage from the nucleus. Bud13 contains a unique, phylogenetically conserved C-terminal region of unknown function [1].	20.60	20.60	22.00	21.10	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.38	0.71	-3.93	44	337	2009-01-15 18:05:59	2007-06-19 15:04:41	4	3	291	0	240	323	0	136.80	36	33.20	CHANGED	-TlaR.Dp.oG+hI.shcppppcpcpcp........................pccpcccpp.ttphspG.lQtpppcpphpchpcttptsh....sch.pDp-hsp.h+pppRhsDPhspa......hppccppss..............thht+stY.............pGssss.NRFsItPGaRWDGVDRSNGFEpchFptpsc	..................................................................................................................cTlaRDt.sG++h..s.h.p.cc.t.ctccpt..........................pcptccc...ph.htphs+G.sQpcppppphcchtcttptPh....ARhh-Dp-h.s.p.L+pppRhsDPMspa.............lpcpctpts................................tptht+stY..............pGssPP.NRasIhPGaRWDGVDRSNGFEpchFtths.t..........................	0	82	130	197
+9569	PF09737	Det1		De-etiolated protein 1 Det1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2558)	Family	This is the C-terminal conserved 400 residues of Det1 proteins of approximately 550 amino acids [1].  Det1 (de-etiolated-1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian Det1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 Associated 1), and a member of the UBE2E group of canonical ubiquitin conjugating enzymes and modulates Cul4A function [2].	25.00	25.00	28.70	26.30	18.00	24.20	hmmbuild  -o /dev/null HMM SEED	407	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.36	0.70	-5.71	8	179	2009-01-15 18:05:59	2007-06-19 15:06:35	4	6	119	0	111	170	0	314.00	37	70.11	CHANGED	REhSLFhp-s+asIluuuohlsc-.shP.......pah-lacss-ulpss..sslEcYThallDL+pGcloDu+sF+sDpIlLuHNpGlaLYsshLAILSlpaQsIaIapVs.-GcFlchRTIGcFCp--Dthhlsps..........pthsssshcpshh.P.....hIsuLKpRlLsFLaRpAcspuussupt.....R+FY+pF-pacpLhMWKMQLLDcchLLIKY....uopDlssL+ss-ss..psShFVlYsIhspplluVYpNsSscLLpLaEpFsDpFRsushtp.t.sFtsSsouNsaup.hppphKpThl..NtchuuppcAs+RlhuuLPlSuQSYSuSPYLDhuLFSYDDKaVSshERPKsCu-aPI+Fhu.RcouLLKF+lpAGspspssPts.sRRLVAFlFHPh-PFAlSVQ+s..stsYlVNFHhR+	..............................................+-h.Lahcssphslhuoush.....pp....s.s.................................sstulpss.....sslEchohallcL.........p..sG..hlhDphhapsDhl.Lu...HN.GlaLa.....pshLullSlp.QsIalh.plt....p.G.p.hlpl+.sIGtaCh-DD.hhlps.........................t....tt..h.s..................hlsulK.pRlLsala+ph.ptts....s.s.......+cFa.hFpth.pLhhWKh.QhLDpp+LhlKa...........sS.Dsssh.Rss.........-............psuFFsVYNh.oo-lluhap.NoSp-LhpLFEpFsDhF+sss.ps.h.pF.sStSss.aAhp...pp......hK........stphusptphs++hLsp.LPhSsQSh..SsSPYhDhsLFpYD-KhlS.sh-R.+tss-pPI+Fhs..R.p.sshlKFcltsu............tt.....s.t.s+.+lsuFhFHPh.PhulSlQps............hlshHh+p.........................................	0	38	59	86
+9570	PF09738	DUF2051		Double stranded RNA binding protein (DUF2051)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2010)	Family	This is a novel protein identified as interacting with the leucine-rich repeat domain of human flightless-I, FliI protein.	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.13	0.70	-5.13	7	400	2009-01-15 18:05:59	2007-06-19 15:58:51	4	3	88	0	181	356	0	199.10	31	66.18	CHANGED	AEARLAA+RtARAEAR-IRM+ELERQQKE..................-pp.D+.a....scpsSpst.ssl...s..............sshsGo..SSRRuStD...Sh-p-s.ShR-l........................+cpLtEVEE+a+KAMloNAQLDNEKsshhYpVDhLKDpLEEhEEphAphpREhcEKp+-hct.K+shshLphphp.l+ppLppRDpLIpcpGLllls..ssNu-su-p.s.......su.shlptEstplLpss...tGsLDV+L+Khs....sEpppL.tplpp.ptpLpth..ptp..h.utpsGsh...........p.........sQ+-uNK.Io-hKhKL.sKu.EpElsNh	............................................................................................................................................................................................................pp...cpth.........t..op......t.t......................................ss.tst......uS+...R....us..t.s......t....t...................................................................................................-+tt...plchhpc.h.p.pp.h....+p.......-.K.............p...-.h.E.+.pKchhshlp.pht-l+-tl...pptcchl.............p......cp...............................................................................................................................................................................h......................................................	0	26	42	93
+9571	PF09739	MCM_bind	DUF2044;	Mini-chromosome maintenance replisome factor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2545)	Family	This entry is of proteins of approximately 600 residues in length containing alternating regions of conservation and low complexity.  The Arabidopsis protein is a replisome factor found to bind with the mini-chromosome maintenance, MCM-binding, complex and is crucial for efficient DNA replication.	25.00	25.00	27.70	26.20	17.10	18.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.72	0.71	-4.57	37	164	2009-01-15 18:05:59	2007-06-19 16:02:28	4	7	136	0	117	167	2	120.10	29	19.86	CHANGED	cphLpsssshp...plP.lNss.slctlps........ssLVRFRsMlQDh.hssEhYlusYcstst.......hcssKYp.Dhhphs.ttth..........pshhhERpshYsVPlPGpssWstppppt.........phtstspssssppKR	..........................phLpppsshp.lPsLsps...slchlps.........soLVRFRsMlQD...M.hsPEaYhusYcshsppst.....hh+tuKYc.Dshpssstpph..ts......psshhERpshas.VPVPGpssWs+pt..s.............t................................................	0	51	67	96
+9572	PF09740	DUF2043		Uncharacterized conserved protein (DUF2043)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2374)	Family	This is a 100 residue conserved region of a family of proteins found from fungi to humans.  This region contains three conserved Cysteines and a motif of {CP}{y/l}{HG}.	20.10	20.10	25.70	21.70	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.91	0.72	-10.64	0.72	-3.96	9	103	2009-01-15 18:05:59	2007-06-19 16:10:46	4	2	75	0	68	99	1	104.60	44	16.58	CHANGED	ths+APlVPaGhDLpYWGpEp.sssp.hp.sspH+FWt.s-.EppVsusclsphhppRplTatGchcslp+h.CpA.h.sGtLCpRpDhhpCPFHG+IlPRDDpGpPlppED	.........................................t.ucAPVlPaGhDLpYWGpcp.ss.......suph...hp....sspHRFWtss-s...-p........plssscluEhhppRpIoFsGchEPlp+h.C+APh.s.....s.Gp..LCpRpD+h.K.....CPFHGpIIPRD-.p.GpPls.p..............	1	23	34	50
+9573	PF09741	DUF2045		Uncharacterized conserved protein (DUF2045)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2465)	Family	This entry is the conserved 250 residues of proteins of approximately 450 amino acids. It contains several highly conserved motifs including a CVxLxxxD motif.The function is unknown.	25.00	25.00	25.80	25.10	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.51	0.70	-5.23	3	168	2009-01-15 18:05:59	2007-06-19 16:11:30	4	8	105	0	103	160	1	208.10	41	49.25	CHANGED	V-pcosFWTslFssYFlcphEsR+p.D.DDLLFFVR+KLupuSS......RshsEsEsElEVY..RRDS+KLPtLGDPD...VDWEESVYLNLIlHphDYTVTlAICTRsusK-........Lpll+K+SQpVYASPSR..++MDSKGEsEcI.oYPcICFMVDsFDEVFcDllVsDGE.MVCVELVAoD......................+ssosQGVIFpGSIRY-ALKKVYDuRpSplGS+hAQ+MSFGaap....po+sEFVRMKGPQGKGHAEMAVS+Vss	..........................................h...t.haWp.hFspaFh...t....ph....tsp.p.............DDhLFaV+.p.hs.htu............ht...s..p...psplpVa...RRp.u.KLPt.ls-ss...................lDWEcolhLNLlhpp......h.sYhlTsAlCo+sssts....................lp.h.p+hoppVaASPS+..+.MDo.K.G................-..p..pl..oYPpIhFhlDsF--sFsch.hl.t-.sE.hhCVpLsApD.....................................................+.psshp.sslF.G.lpYpsl+.csYDs....phS...........hu..u................h.h..S.hGh....................s.ph-hlh...M+GPpG.+GcsEhAVots..s.............................................	0	35	50	76
+9574	PF09742	Dymeclin		Dyggve-Melchior-Clausen syndrome protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2225)	Family	Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteristically about 700 residues long and present in plants and animals.  Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterised by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation [1]. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus [2]. 	25.00	25.00	27.20	27.20	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	678	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-13.23	0.70	-6.42	25	291	2012-10-01 19:21:38	2007-06-19 16:27:57	4	7	170	0	171	566	11	481.00	28	87.39	CHANGED	MGss.S...................t..chphpph.......hthhssppsss.ss-sF..WspLhph.hphspssp-hh..lsut..phhpshh.sNhsohshttlhphhhtp........sphttspcpps.........................shNslhllspllp..ahhE..p.tpsphhthhhtt..t..........................................................shst....t............................h.shsphEphhpshls.hhss.ss...............sstp.th+hEhlplLLshhSsplatsssst........ss.ahphhhp...tpsptsssLhsoLLpphhphssssh........ph.hht...................uhh.hhsts...hh...............................sst.sp+sPLu..stulplLLlLhsapss...........................psNsapp..slshhpchcp............t..hpu.sp.ts..h.lsastL......hsol............sp...hhtppphllLLYpLlcpNppFhpYlLs.+uD.lpslllPILphLasuppc..................................................psphlahslhlLLlLSpDpsFspslpch........................h.hssls.Wh..p-hslt..........pho............lGuLlllVlh+hIphNhp...+hp................sh.LasssLuslsNhSsah+sLshhsup+LlsLh-hLop+ahphssthspch............................t.........h.hhpphl+hlLEllNuhls..hplctNspLVYsll+......+R.plFpphps........c................................................................................................................................................shhpcl.lpsItpl..Lpaasspl-.....phsssp...hs............hsclLchIpcushs..............................sstslp.....................as.lhacYppcptsppaF.hs........YhWsl	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhh..h.s..hh.........................................hh.......................h...hl..h............................................................................................................................................................................................................hs.....p.sh.lLllLhp.hpt...........................................................t.s.sapt..hl..h....ts.p..............................................t............h..pl..s.hs.L.............h.psh................................st......tppp.hlLLY...LlctNpphhp..ahh..psc...h.pl.....l.hPlLph.Lapstpp....................................................................pst.lahhLhlLLlLo...pDpsFst.pl.pph.......................................h..h.sls..ah...t-..+.h..t.....................phS.....................lG.uLhllllh+sI.p.hsht...+hc.......................s.hL.asssLshLuN..h.....u.s.h+p...Lp.asup+lls....L.hphls++...at+h...p.hppph..............................................................................t.........................lphhpchl+hlLEIlNuhLs.....................tL...pNsplVYsllh......cp.plFp.hts............p.........................................................................................................................................................................................................................................................................s.htcl..hpsl..h...lthh...h.....................................t........s........................................tthhthl..t.s..............................................................................h.................................hhh.....a.tp.....ah.h...................................................................................................................................................................................................................	0	77	102	141
+9575	PF09743	DUF2042		Uncharacterized conserved protein (DUF2042)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2235)	Family	This entry is the conserved N-terminal 300 residues of a group of proteins found from protozoa to Humans.  The function is unknown.	23.20	23.20	23.20	25.10	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.61	0.70	-5.09	17	181	2009-01-15 18:05:59	2007-06-19 16:28:15	4	6	143	0	136	188	1	250.30	35	35.86	CHANGED	ElpcLttcFpcsQhsp.ssp+LSERNClEllpKLlccphl-..llaThDGKEYlT.spLppElpcELhspGGR...lsll-LspsLNVchs+lEptspcllcps..slphhtGpLlscsYl-plspElN-cLpEpGplslu-LsppacLss-Flp.pllpt..hhuplIpGphsts.....hlaTpsalpppcuplRGsLhAhTcPsslsslhpp.............hthppplhhsllpsLlst..splpGphhG......u.YlPphYppspsshVcsaacQNGalEassl.ppLGIsssppalp	...............................................ElpcLttphptsQ.sp...ssp+LSERN.slElls......KLhppp.hl..-...llaThDG.KEYlT.tplp+Elp-ElhhpG........GR...lsllDLt..phlsVDh..+lEpphpclhp.....ppt...p...........l..p.ll....G.p.LlspsYl-plspElN-pL.........p-p..Gplslu-Ls.ppasLsu.cFlp.phlpp....clGp...lIpGph-ts.................hlaTpualsRp+AplRGhhsAlT.+...Psslsslh..pp...............................................hsh....p.....pplhh..sllppLlpp...upltGplhG.....tuhalPslaspsQpphVcsFapQNuYl-a-sL.p+LGIscshpal.................	0	55	74	112
+9576	PF09744	Jnk-SapK_ap_N		JNK_SAPK-associated protein-1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2077)	Family	This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF Pfam:PF00621 domain at their C-terminal end.	24.10	24.10	24.10	24.10	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.11	0.71	-4.24	6	354	2009-01-15 18:05:59	2007-06-19 16:29:01	4	5	89	0	191	319	1	144.20	40	16.80	CHANGED	VpsLAsuIY+EFERlIcpYsE-VlKpLMPLVVsVLEsLDulhu-NQ.ch-lEhpLLc-DpcpL.sQYEREKpLR+pAEpKllchEDshEpE+K-Lpp+l-phEppsRpLELKhKNhs-pluRLEEREs-hK+EYsuLH-RaTcll+sYlEalERs+hph	....V.slAuuIhpEFERlIcpasp-.sVppLMPlVVsVLEtL.........-.........slhs....cs.......p..cpcl.Elc.hL+-..DsE.pL.sph....c....c....EKth.R+p.t...E.....p....chlc..h....E....DshctEp+...-Lpsp.lppLEp.ps...+pLp....hch.+.N....h...u-...p..................h..s....+....L....p.EcEsp..h..+pcas.slpp..RcsphhpphhEhl-+p+...................................	0	48	65	126
+9577	PF09745	DUF2040		Coiled-coil domain-containing protein 55 (DUF2040)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2117)	Family	This entry is a conserved domain of approximately 130 residues of proteins conserved from fungi to humans. The proteins do contain a coiled-coil domain, but the function is unknown.	25.00	25.00	25.60	25.10	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.76	0.71	-4.32	30	288	2009-01-15 18:05:59	2007-06-19 16:33:23	4	10	235	0	203	277	2	119.30	38	29.80	CHANGED	+pscpctpcAhp...pDsolasYDulYDsl+.tt.pctppsp.pscsp.+cPKYhssLlcuA-pRK+-pphspERpLt+EREtEG-pauDKEKFVTuAYK+phEE.++hpE-.Ecc+-chEcppctspttshh	..................................p.pschphpcAht...tDsola-YDslYDphp.....ttpp...cpp.t..t.h.......t..pp............++P....KYIpsLlcuA-hRK+.-pphthE+plp+EREtE.sc...c..F...sD.K.EtF.VTuAYK+p...hpEhcch-Ec.E+cc.pthEtptchsptts.u....................................	0	73	110	159
+9578	PF09746	Membralin		Tumour-associated protein	KOGs, Finn RD, Coggill P	anon	KOGs (KOG2092)	Family	Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers [1]. Membralin-like gene homologues have been identified in plants including grape, cotton and tomato [2].	23.70	23.70	24.30	24.20	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.39	0.70	-5.41	3	172	2009-12-07 11:10:06	2007-06-19 16:39:37	4	5	100	0	123	196	0	233.70	36	53.94	CHANGED	uQNPLINVRDRLFHALFFKsAlTYAcLVP+sVRRsIEFllLLKALLsFFILlYIHluFS+oPsTCLEHVKNcWPRDGILRVEIls.suc++sIaLpht-ssollRslK-suhhuI-PpTcpsHEolEpYQNsplKLpLslcPosahssppLps....pFDuENhosThSascAhSht.-sWs-EQYIVEYSLEYGFLRLSuSTRQRLNIPVhlVsLDPs+DKCFGDSFSRFLLKEFLGYDDILMASVKsLAEQEENKGYLRNVITGEHYRFVSMWhMARSSYlAAFsIMlLFTlSVSMLLRYSHHQIFVFIVDLLQMLEaNlSlRFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWlADQYDAICCHTSlTKR	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YshEhGahh.Ls.ts+tchpI.sh.lplss.pp.C.FG....sth.pphllpphlGYDslLhsSlht............p..spG.aLhNh.otEhY.............p......h.....s.....................h..................hths.s.....a......s........s........hh...hhhh..h.....o.htluhhL.R..spp..phhhFh...h...pl........p.....hhphp.s....h.......h....hh..hshl.......hhl.G..h.hhh.EFasDp.hAFhlllhVWhs-.ashls..s+osho..........................................................................................................	0	49	64	103
+9579	PF09747	DUF2052		Coiled-coil domain containing protein (DUF2052)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3044)	Family	This entry is of sequences of two conserved domains separated by a region of low complexity, spanning some 200 residues. The function is unknown.	25.00	25.00	31.80	25.20	23.90	23.60	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.46	0.71	-4.35	20	236	2009-01-15 18:05:59	2007-06-20 11:01:27	4	7	195	0	184	239	0	155.60	26	58.63	CHANGED	NRRhthLppLlpcu-YFS-ppMc.R-PLLY-phlGpa.oppE+pscspsc...t..........uhuulLhsslp+pptchpltcpp.....p.-t.t...-pcspt...................p.p.s..sp..t-p.............ts............................ssp-+-.hc-cFhshMpp+FLsGEDcD.FDYopVDsss-aDD...c.hppDcEE+YF---	.........................................................NRRhthh.pt...................ps.......p....YFS...t.th........c.t......pPhLYcphl.....tpa.s.t-tptps.hc.................shushL.t....ph.cp....ph.p..t.h.tp....................................p...............................................................................tp.....p.....t.......................................................................ssppcp.htppahthMpp+FL........pGc.Dp-.aDYst.lDpst.phDs.........tpDtE-+YF---....................................	0	65	102	150
+9580	PF09748	Med10		Transcription factor subunit Med10 of Mediator complex	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3046)	Family	Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription [1]. Med10 is part of the middle region of Mediator [3].	21.50	21.50	21.80	21.90	20.30	21.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.50	0.71	-4.32	18	291	2009-09-10 23:46:38	2007-06-20 14:56:13	4	7	256	0	209	273	0	121.30	33	74.23	CHANGED	hppplcplIEshhpLslhVp-Fp....P.......................soppsLtp+lssLlpsLpplpchspp...............................hps...............lp..lPlEV.lpYI-sGRNPDlYTREhlEt.shcpNphh+GKhcuh+chRcsLtcElpcpFP-hhsphcsI	........................................................l.ppplcphlpslhpltlhVpsap.....s..........................poppsLsp+lp...pl..lpsLpplschppp...................................................hps...............lp..lPhEV.l.cYID..p...G..RNPplYT+EhlEt.shtpNpthKGKh-uhc.pF+shLhpElspsFP-.htphctl.................	0	67	112	168
+9581	PF09749	HVSL		Uncharacterised conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3102)	Family	This entry is of proteins of approximately 300 residues conserved from plants to humans.  It contains two conserved motifs, HxSL and FHVSL. The function is unknown.	26.80	26.80	27.80	27.40	26.40	25.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.62	0.70	-5.35	27	269	2012-10-03 21:31:48	2007-06-21 09:20:52	4	6	231	0	194	278	2	211.80	23	79.87	CHANGED	PPlPpshh-hhts......t.p.pDs....sshHsGRhRsh.HhcGNWsoa....lY..lthtsspt...hchlpphlsp.hpphhhhhphp................sth.....s.h.LHlSLS+slslcp.cphssFlpplcptl....sshpsFtlphss.lp..hhsNt-cTRhFLsLclsp........spsst...LpcllptlscshpcashsshY..........................................psspFHlSlAWsl.ss.ptphp...ct..ph..phhpth.p..................phpsspl+s+lGNpshshsL	..................................................................pp.....t.ctuRhRt.h.H.pGsWsoa....lY....l...h.....sptt........hp.......hl.p.tlltp.htp.h.t.................................................................tshHlSLS+slslpp.cthpsFlptl+ptl....................sphpt.....Fhhphsp...lc..hasN.p....-p.TR..sFluLpVsp.................................sttp......lpp.llp.hl.spshpp....a..shsphY...................................................pssphHlSlAWsl.ss.ptphp...t...p....p...p...htth..........................................ph.hpplph+.Gpthhph.........................................................................	0	55	93	149
+9582	PF09750	DRY_EERY	DRY; 	Alternative splicing regulator  	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2548)	Domain	This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins.  This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA [1]. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains Pfam:PF01805 and an Arginine- serine-rich binding region towards the C-terminus.	25.00	25.00	27.00	27.00	24.30	24.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.64	0.71	-4.01	17	271	2009-09-10 16:58:51	2007-06-21 09:30:53	4	11	117	0	173	284	0	124.10	33	17.96	CHANGED	p.LplaGpps+latDsthAtAs-ssptL...hPW...Gspp.hIDRaDsRuhL....shh.......ttsp.sp..phs..ppttEphhshERYhsLhpsch....................ptthppcpppphsppptp.tshsslGFoYssst	........................L.VaGhuCKla.hDs.thAhst-psppL...lPW.......G........D..p..shhIDRaDsRutL............chh.........................ts..sp.hpho.tEptp.Ephss.ERYhsLhpspht................................................tt.pc-chpphtpt.....t..t.tthsslGasYtss.s.....................................................................................	0	60	85	130
+9583	PF09751	Es2		Nuclear protein Es2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2627)	Family	This entry is of a family of proteins of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong.  Apart from a predicted coiled-coil domain, no other known functional domains have been characterised. The protein appears to be expressed in the nucleus and particularly highly in the pons sub-region of the brain. The protein is clearly necessary for normal development of the nervous system [1].	20.20	20.20	21.30	23.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.70	0.70	-5.06	34	313	2009-01-15 18:05:59	2007-06-21 09:35:03	4	10	226	0	243	314	2	326.40	27	74.37	CHANGED	cptpVLsE-sYlpsLpcIIpRDFFPcLhchpspp-Y...................L-Al-spDhphlpphp....p+hpphht..............oPsphcss...sh....st.s.....ssspsss.ssh......tt-p..t...ttptt................................phuLspF.s+YTSEDNcSFpcll-ptppKcp.cKauWlap.scttpspplt.t...............................t.p.ssppt.....lc..........................sp.st............................................................................................-tW.ph+scNsLMahPsuspss..-sltptsct.........pclhapNTRh................pt.s.shsps......uhstlpcAhttp.p.p.sch.....ssc..........oPc..........VNGY......uaVcss.pPss...............t.sPlhTaGclpsT....Phpl-s.c..s.......tsss.......................ssFpI.Ess+REpluc+hsccsu.tKppp+p..............tpshsos.....t..ss.tls.........................LoPAA.Q+L	........................................................................................................tlLcE-pYhpslppIItRDFFPsl.chpspp-.a...................L-A.pptD..hhtpht.......chtphh.................................s.ht..tt..................t.....................................................................................................................................................................................................t.thoLstF.t+YTSEDNtSFpclh-ptpp+pc.t+aualap..s...c..ttppht................................................................t..p.....ttt...........hp..............................................tt..t...........................................................................................................................psW..p.h.pscNsLMahPp.uht......p........pph....tt..p......................pl.apNTRh..........................p.....shs.p......................shstlppshthpst...tp..........s.t.............oPp..............ssGa.......shVtss..pPtP...................t.t..sP.....hh...T....WGplpsT....Phhlpstp.............s.s............................ssF.+......l.-sspREplthphspcsu.tp.ptpt.................tt..to................s..th....t................................hoPAhp+h.........................................................................................	1	103	146	204
+9584	PF09752	DUF2048		Uncharacterized conserved protein (DUF2048)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1551)	Family	The proteins in this family are conserved from plants to vertebrates. The function is unknown.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.00	0.70	-5.57	11	211	2012-10-03 11:45:05	2007-06-21 12:56:45	4	4	135	0	126	523	39	304.20	34	88.08	CHANGED	o+FFs+GWGc............chlcclhs.ct.lppR.......sPsshtlclspshppcssp.....lt-GpFtSPht..hsuhLPspucpA+hphLlPpph....h...+slCl.HLAGTGDHsah+Rcph.AcPLLK-.sluullLENPaYGtR+PppQptuuL+sVSDlalMGuuhlhEupsLLpWhccc.GaG..lGloGlSMGGpMAuLsuoshPcPlu.....lVPhLuhsoAssVFTpGllppulsWchLcpp...............................................................................................................................................................................................s.t........tpppsts..pEulR.hhthh.stTslpsFssPhsPphsIhVsAccDuYV..P+pust.sLpphWPGuElRa...l-u.GHVSAhlhHpchaRpuIh-Ah-R	................................................................................................................................................................................................................................................................................h...........t................pu.F.os......thhP..s....A.hhthlh...........Ptt.......................c.hsl.pL.A.GT...............G..D.H.h.a.+Rhph..utPhlKc..thuollLE....sPa......Y....G....R.+....P.t...t.Q....h.....t.S...p...L....p...s..V...S...D.....l...h...l..h.G...t.s...h....lhEst.sLLp.Whcpp....Gau....lGhsGlSMGGh...hA...u....lsso....saP...c...P...hs........hl.P..hL....o...........s.............o.....A.ss.s....Fsp.G...l..h.......p.....uh.s....W..t....Lp..pp....................................................................................................................................................................................................................................................tp..p.p...p.....hEs.l.......h.h....h....t.hh..p.h..T..c..lts...F..s..s.Ph.c.s..sh....l......lhVtApcDuYl......P+p...ssh..pLpch.W....P.G.s.E.lR..a...l..p.u.GHloualh+...p...thFRpsIh-sht........................................................................................................	0	47	65	99
+9585	PF09753	Use1		Membrane fusion protein Use1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2678)	Family	This entry is of a family of proteins all approximately 300 residues in length. The proteins have a single C-terminal trans-membrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are essential for membrane fusion and are conserved from yeasts to humans. Use1 is one of the three protein subunits that make up the SNARE complex and it is specifically required for Golgi-endoplasmic reticulum retrograde transport.	29.40	29.40	29.40	29.50	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.61	0.70	-4.94	11	304	2009-01-15 18:05:59	2007-06-21 14:54:11	4	8	223	0	200	291	0	221.70	20	82.89	CHANGED	S+LElNhhRLLu+CEthAp...EcpppspWRLcKaVsuLccMlspLccp..........hsKPos-hlsEYsc+lshLKullpupch.............................soss-KshssphLusups.sthsptcssso+p.............l+.pppu+hpsEhRpELls................sssuhp.ptshhtpp...........................ts.sssccpussclDphlphHpslQEKLA--MltLARNLKppo.sApslIKpDspsLspSt+hsDpNlspLppES-RLEpHupKusp..hahWlMlhlVhhhFIsMlLFI+lh	.......................................................................................................................................................................................................................................................................................................................................................................................t.thh......th..cht.lt...ht....p....................................................................s.....ptt...tp..s..t............p..t.s.t................................................tt..........sphRp.chht..........................t..................................................................................t....t..pt.ps....ttph..-t.hp....tpcphQEcLsc-hlpLAppLKps.ohs.h.ppslc...pDpphLsps...tcth-ps...h...pphppt....sp+...l....pp.h..t.p.p.s.hp........h.hhh.........h.....hl...h.h.l...hh.h.F.l.....hllhh+h.........................................................................	0	63	103	159
+9586	PF09754	PAC2	HCCA3;	PAC2 family	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3112)	Family	This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits [4].	22.60	22.60	22.60	23.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.33	0.70	-4.49	126	1323	2009-01-15 18:05:59	2007-06-21 16:27:51	4	4	791	13	568	1106	677	221.70	21	77.96	CHANGED	hlpGhsssGpluplAscaLlcph..chchlupl.ps.phhs.....Ph....shhpc.s.........thhhsshclYhsps..tt.....................lllltup....s.ss.hthp.......paspt.llshscchslppllsLuuhsssh.c..pps...slhshssspchh.pphp.............p.ppht.....s.sGssuhlhths.tptshsuhslhstss........................t..hs.....sPpAutsllc..sl.sch............hslpl.s..hspLtccA...p............-hpphlpp.Lpc	..................hhpGass.sGpsuphAsctLhpph............ptchlupl.cs.-thhsh.sp......pPh...hthps.s......p..........thths..shplahsps.tt.....................sllllpG.....spPs...hpac.......paspp.lhshs.c.ch..s.lppllsLuulsssss+........s+s....hslhs.hus..s...sphh..pphp..........................htchp............sss.u.hss.ll.tth.tppsh.ss.ls.hhstlP................................pY.hs........sPtAshsLlc..tl..pch.............hslpl..s...hs..sLtppApphp...............Eltphlpt.L..t..................................................................................................................................	0	182	378	494
+9587	PF09755	DUF2046		Uncharacterized conserved protein H4 (DUF2046)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2129)	Family	This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.12	0.70	-5.54	3	169	2009-09-10 16:40:10	2007-06-21 16:31:04	4	5	127	0	120	159	5	230.70	45	56.20	CHANGED	A-CsSESDoDGuTscsSSouSp.........EcLpsRIcSLpQENKVLKhELDTFKLKCKuLQEENRsLRQASVoIQAKAEQEEEFISNTLLKKIQALKKEKETLAhNYE+EEEFLTNDLSRKLsQLRQEKscLEQTLEQEQEaQVNKLMRKI-KLEADTluKQToLEQLRREKVDLENTLEQEQEALVNRLWKRMDKLEAEKRhLQEKLDQPVS-PPSPRDhh..oputDTsssluSHI+uLRSEVcRLRcNLAsSEt-aTEKMpQYAcEERphREENIRLQRKLpREVERREALCRQLSESESSLEMDDERYaNE.l	.....................................................................................................................................t.p......hc...phth.+h+sphltc.-.+tL+psuV.lQu+AEQE..............EEaISNoLhKK...Ips.LpKEKEsLAhpYEpEEEhLT.....NpLSR.KL...QL...ppEKs.cLEppLEpEQEh.VNKLh+....+Ic.......+....L..............cs-p..s.pp....p...............LE.......pLR+...Etl-.LENsLEpEQEhLVN+LhK+h-cLpsEKR...LQ.+...Lpp...hs...t.s..s.....t...................t......t.............h..lptEh..p..............hpt.h.........................c..........pthttpNhphpp.l..phtch.th.pt.......................................................................................................................	0	59	73	99
+9588	PF09756	DDRGK		DDRGK domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3054)	Family	This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.	23.30	23.30	23.30	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.26	0.71	-4.89	16	209	2012-10-04 14:01:12	2007-06-21 16:39:39	4	4	157	1	132	209	5	164.80	40	57.11	CHANGED	tclupKcttKh.ptKpt++ppREhEctpREp+c+hptp+.tchppp.....c-pcctpcpccEcpccctcEEpcc+EpEEYp+hKupFslE-pGppptps--ptp....hlpcFIsYIcppKlV.lE-LuscFsl+Tp-sI.cRlpsLptpGplsGVlDD.RGKaIYIos-ElpuVspaIpp+GRV.ohs-LsptsNcLIs	.......................................................t..hst+chtKh.ptK.pt++tpR.c....t-pt...t.REpR+.phpptc-t.ch+cc.................--cpc.pEppcEE.tp+p.t.+E....EpcccE...p.EEY.+h..KtsF...sVEE..EGhtpp.sc-ppp.....hLpcFl.pYIKppKlV.LED.LAupFtl+Tp...-sI.sRIppL.spGploGVh.DD.R.....G.KF..IYIo.-EhtuVApaI+p+.GRV.SIs-LuptSNplI............	0	53	73	106
+9589	PF09757	Arb2		Arb2 domain	Wood V, Bateman A	anon	Wood V	Family	A second fission yeast Argonaute complex (Argonaute siRNA chaperone, ARC) that contains two previously uncharacterized proteins, Arb1 and Arb2, both of which are required for histone H3 Lys9 (H3-K9) methylation, heterochromatin assembly and siRNA generation [1]. This family includes a region found in Arb2 and the Hda1 protein.	19.20	19.20	19.30	19.20	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.12	0.71	-4.84	43	409	2012-10-03 11:45:05	2007-06-21 17:39:30	4	19	222	9	275	398	1	154.40	20	27.75	CHANGED	sPcchhp.........hphhcpshh.pppaacshtp..............................sI+ph.hpcLppc.thl....LP................hsshsp.....p.ts.Ihsosshh.pspp..lllllHsssp....lWAppss.hsssl-suosls.......................aIphu.................................tpcshullslNhsphhhp..........t.t......sshpsshpsp-hsthla-s	..................................................................................p............hphhpphh..ppthapsh..................................................................hlpph.hphLtpp...thl.....lP................................................hssh.p.....p.cs.lhh.S....shh..pspp..llllla.s.ss................Wupp.....hh..hs.....psl....ctuotls.......................alchA......................................hppsaullshN..sp.hh......................t.pt......t..........h...h.......................................................................	0	74	138	218
+9590	PF09758	FPL		Uncharacterised conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2219)	Family	This entry represents an N-terminal region of approximately 150 residues of a family of proteins of unknown function. It contains a highly conserved FPL motif.	21.30	21.30	21.50	21.50	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.89	0.71	-4.43	18	233	2009-01-15 18:05:59	2007-06-22 10:31:58	4	4	148	0	162	219	5	135.00	47	16.91	CHANGED	lRpIsEhlIWGDppcsp.hF-aFhEcslhsphhcllpp.p..sspslplpllQolohLlpNlppcpslaYlLSNsplNclIsapaDhp....c-EllsYYISFLKoLuh+LspsTlphFFNp+hs...sFPLhscAl+Fhsap-sMlRsusRsIlLsIh+	.................................lRsIsEllIWGDQpD.ss.lF-.........FFhE+shhshFlpIl+p..p..ssphVslQLLQTLsILhpNlppEoSLY...........YLLSNNalNslIs.....ac.FDFs.........................DEE.lhuYYISFLKoLSlKLNpcTlpFF..a.Nccss.................sFsLYsEAlKFhsH.sEoMVRhAVRTloLNVa+...............................................	1	72	100	136
+9591	PF09759	Atx10homo_assoc		Spinocerebellar ataxia type 10 protein domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2676)	Domain	This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localisation, specifically to the olivocerebellar region [1].	24.70	24.70	24.70	26.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.02	0.72	-4.28	20	296	2009-01-15 18:05:59	2007-06-22 15:02:31	4	5	255	0	203	293	0	93.20	31	16.29	CHANGED	uhKppllcllusLsacsp-lQ-plR-hsG.ltllLssstlD-pNPal+EaulhsIRNLhcsNscNQchlupLcspsl..scsshLpchGhclpl.ps.G+lplcsp	.............................thKp.llpllusLs..acs...psQcplp..............ch..sG..l.hlLss.C.s....h.D....cp....NPa.....l+Eaulhsl+.Lh-sNtcNQchltpL.c..tpth.......spss..hLpp.hGhph....t.tp......p........................................	0	65	112	167
+9594	PF09762	KOG2701		Coiled-coil domain-containing protein (DUF2037)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2701)	Family	This entry represents the conserved N-terminal 200 residues of a family of proteins conserved from plants to vertebrates. In Drosophila it comes from the Fidipidine gene, and is of unknown function.	25.00	25.00	28.30	36.20	21.10	19.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.98	0.71	-4.22	14	147	2009-01-15 18:05:59	2007-06-22 16:15:42	4	4	105	0	94	146	3	172.80	51	30.58	CHANGED	php-Il-lLlsAGYaRARlpuLSsFDKllGGhsWsIpss.s.....aclDl-hhFpEs.......oIGpKIuloE+IlpsL.cM+CPapLcPHQIpGLDa.slaPVlpWLlK+slEsRpEpu-hl+pauhspFppcas.h.scp..-hhppcpcsspsltshpchatPpR.....hcR.tss.s.hhsc.ppscpsLhEYGp	.......p.hp-Il-LLVAAGYFRARIKG...LSsFDKVVGGMTWCIosC..s......aDVDVDLL..FpENu..........................TIGQKIALoEKIVuVLP..+M..KCPHpLEPHQIQ..GhDF...IpIaPV...lQWLVKR.ulEs+cEhGDalRpauluQ...FpKpap..hspDc......-hhpcpcpshcslhslpchYpPpR....ha+R..ttss.........pph.--tsclc.sTLLEYG.................................................................	0	35	45	76
+9595	PF09763	Sec3_C	Sec3;	Exocyst complex component Sec3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2148)	Family	This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	701	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.38	0.70	-13.14	0.70	-6.40	24	414	2012-10-03 17:31:52	2007-06-22 16:27:39	4	6	269	0	278	545	1	511.00	21	63.19	CHANGED	p-...............u-shhccLs+ELspl-tss.lpsllpp-ppssplhphl.-pulsEsDcl-shLshaphpLpslp--lshIEspspGLQlpssNpKhLhpELppLLsplslscsplpsLpp.sslppsptlcth..EsuhtsLhpAhsslp.......................shcsshsphpAlpp+cphacchsppFhcRlspahpptFp.h..p.hpt.p..............chshppatshhppLhhYusLhhahK-lstcpaptLhptYpsphpplYcp-hpphhpth+tphp.......................................................t.pspptptsh.sss..........t..pph....hshpps+phph..................ppuphh.................................tp.p..cshtthLsphpslhhhcQsFl.pFF......+hss.......................................................shsas-hlpttssppppt..phsphp.hc.........ss+ths.pplpphhstlFts..h.scl.shls.s..phcsh......s.slLhhl-ptl.phpp..s..sps.aL.phlt+lhtplpp.as+alppQlctIEc.splsh+pp.GllshlpsFs.FsptsEshhppspp..............hssh.hl-puYp+lspuhhctlpphs.....t............................................ppppphspplshl....ENhpahhcpLs.........................hph......sslpshhcpupphaccphphYhp.tlltcshs+LhpFhpuscshlps.....s.sp.uhphuaSKptl+pllssYsu+-lcpslcpLh++l-KHF..t.p...........................shpcsLlp+lWpshpppalphap+ltsllp.csYss	............................................................hp..hcth.tplppclt.hptss.l......ttl..tp.-.....h.......p.lhphl.-tshtps-p....h....-.hlp.a.......p..L..pp........hpc...........pht.Iptpsphl..phpstNphhLhpclp.llpph.p.l.st.t.ht.Ltt..ss...h............tp.p......ltth........uh.hL.tsh.........................................hp.s.th...h..u..lppppt.htt.pt.Fhp+h.paht.ha.........t.t................................ph...tp.t.hht.lh.as.Lh.....ah+th....s.ttat.lhp........Y..p.hp...l.hppphpthht.hp.tht.................................................................................................................t.......................................tttt..t........................................................................................s.................................................................t.hhtthLtp.h...hh..EptFh.pFh.....php................................................................................................................t....t.ht.........tt............................................t.htthh..lht.....h..ph.thht.h...p...ssh.....................h.hhhhhpphh.....tt.....s.........stt.al...hh..tph...thtt.apc.hl.ppp...h............pthpp....scht....h....pp..t.Gllshh..h....h.thhEthht..................................................................................lsp..Y.pl.tshh..lphhs..............................................................plhhh.....cNhthh.t.l..........................ht........sLtt.hppAp.p.hppthp.Yh....hh....ht+l.tFhpthpthh.t........ht.tpl....sh..p.shs+t.hpcl................ltt..s.pp.....l.....ccslpthhc+hpKph...........................................pptLh..lhpt.hpt.hhp.h.th.thht.thY............................................................................................................................................................................................................................................................	0	107	168	238
+9596	PF09764	Nt_Gln_amidase	WDYHV;	N-terminal glutamine amidase	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3261)	Family	This protein is conserved from plants to humans. It represents a family of N terminal glutamine amidases. The enzyme removes the NH2 group from a Gln, at the N-terminal, rendering it a Glu.	20.30	20.30	22.00	21.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.65	0.71	-5.00	14	159	2009-01-15 18:05:59	2007-07-09 17:17:08	4	5	132	1	108	172	5	164.70	40	77.58	CHANGED	hYsSpYCEENVaKLsEhl...t..psshppha....AVFIS...........N-pKplPlW+Q+uups..sss.VlWDYHVIhlp.......sspsutshVaDLDosL......PaPs......shppYlpcuhps-..tplpspa.........RRpFRVlsucpYLppFuSDRSHM+ctsGsahpPPP.aPsIpsscus......hNLss.alsMp.pss.................GtVhs.sphhphFu	................YsspYCEENlaKLCc.l.....tt..p..t.....hp...cha............sVFIS..............Ncp+hlPlWcQ+uuts......sss...VlWDYHVlhlp..........................sssspshVYDLDosL......PFPs......sappYlpcsh+s-...sl.pspa..............+RhFRVl.AspaLppFuSDRSH..M.......+....c.s..s..G...s.....WhpPPPsYPsIts.sssp.....................NLsp.aIsMs.t.s...................G.Vhs.tph.p.a.h.....................................	0	44	58	85
+9597	PF09765	WD-3		WD-repeat region	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3268)	Family	This entry is of a region of approximately 100 residues containing three WD repeats and six cysteine residues possibly as three cystine-bridges. These regions are contained within the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2. The WD repeats are required for interaction with other subunits of the FA complex.	25.00	25.00	27.80	25.70	20.20	22.40	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.74	0.70	-5.13	9	143	2009-09-11 16:53:32	2007-07-10 10:43:26	4	7	100	4	91	139	4	227.60	33	69.28	CHANGED	LhcchPhLlsps.+ptshh.talusptpsa.+l+lhLPccspLcsu+lhs.hthcplhhthppsspp+lpps..L.uFl.cLcplLEstLKspsttps.....sphhosLhp-ltsltas+hshl..Dsshopl+Lpu.Dut.RpHhlTlclpuphshcss-asls.slshuhsht..puoLtshhspFlthLEsLcsFaDshc-IDEhsaVLEPppssppsosRhIslsppV.lplplcPtcPhhh.tshhLu...ss+.Vs.LRphLssslc.WDPEsslhpNLhclh-l.tFPh.	.........................................................................................................lph.....................h.h......th.........t..........p....p.ht.ps..l.thh.pl..ll..h.p...p.......s..........sphhsplhp-lt.tlGWsplh.l..ssshsplchph.Dst.tRpHhlplpl....s..paP....h....psP...s.h.sshPh....hth.pas.............p..............o...sLhslhpQFhttl-.pLptFWcshD-IDcpsWVL-PppPspus.s......hRRIslus..ssSlplpl.cPtcPphlP....pshhLu...ssp...................hlp.Lt..p..hsp.sh..phWssc....pslhpNLpplLph.thP......................................	0	33	45	69
+9598	PF09766	FimP		Fms-interacting protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2216)	Family	This entry carries part of the crucial 144 N-terminal residues of the FmiP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C-terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.	26.80	26.80	27.50	26.90	26.40	25.10	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.24	0.70	-5.38	17	303	2009-01-15 18:05:59	2007-07-10 13:56:45	4	8	220	0	209	278	2	260.80	32	53.71	CHANGED	lpL+chsRhshhphccsR.cpscctKppVDttpLpLpNLhYEtpHLp.......KEIp..pCh-FKopct......cl-Lls.-EFap.cAPppls......csphsttspHp.hLtRLsaELpQRKcLscphccLpppKppltps.Itp+cchL.sSLtspL+...sltpuohPlQchlshsapp...p.cppc.......hsphLPtPLYlLYsplpuhtpsp-c......tlplpIh...Gs.c-Apshtpt................pspppspssp-sccppppp++Rcpptphp.sstp...pphhc.hHP..........Lplhlclhspct...............ltLpFp........YlspLplVsVpsphsst....................-slLssLFs.......sDsGp........chP.................p.ssph.hpchsl..pphsp...t..hG+PYpWsQpLsGlpah	...........................pL+thNR.shhph+ps+.ppTtcs+pclDthcLQLQNLhYEh.HLp..............pEIs...tC.pFc.s..+ap.......................pl.LlshE.EFhp...ptPtpht.........................ttscsHphhlsRLsaELpp...Rc..cLtpphpclhppKpplhp-..pp++chL.ssLt.cLp....plh.pAu..hPlQchh...th......................................................s..h..h.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	83	122	172
+9599	PF09767	DUF2053		Predicted membrane protein (DUF2053)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3236)	Family	This entry is of the conserved N-terminal 150 residues of proteins conserved from plants to humans. The function is unknown although some annotation suggests it to be a transmembrane protein.	21.70	21.70	21.70	23.10	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.91	0.71	-4.24	11	161	2009-01-15 18:05:59	2007-07-10 14:12:23	4	5	123	0	102	168	2	149.60	45	65.19	CHANGED	TLFHFsNChALsasPaalsYKsouLSEY.suhhpClpAussYlhTQLsKhllLA....TFhsss-s....ssashhsEhL...+t.hshlDlhGLhLllop...hssctch+llssGLGWuhA-slho+hlsLWVGARGhEFoWcYl.pul-uNh.LlpplshssL.lahhoR	...............TlaHFhNChALsa.hPaalsYKtosL.S....EY.su......hhp.Cl.pAussY.lhsQLsKhLhLA................TFass....-s..............s.a..-...hhsEhh...KsslDlhDllGLh....hlhop...hs.GKuchKlhssu..LGWAhA-hlhoRhl..P.LWVG.A.RGhEFsW+YI.hul-SNlsLV..phlshusL.lWhaoR........	0	39	53	81
+9600	PF09768	Peptidase_M76	Ku70-bp; 	Peptidase M76 family	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3314)	Family	This is a family of metalloproteases.  Proteins in this family are also annotated as Ku70-binding proteins.	25.20	25.20	25.70	25.40	24.20	25.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.29	0.71	-4.80	29	315	2009-01-15 18:05:59	2007-07-10 15:56:33	4	8	269	0	235	318	5	167.90	37	67.56	CHANGED	pppCpchhchhlphSPhVpFhhpplc+ls.......ss....hppppIhCc...................hCsst.........puGGFsP........ctGIllCpNpl...............+sctclEcsLsHELlHsaDch+hc.lDa...tNl+HpACSEIRAusLSG-C+ahpEhh+tshs...phtp.......paQcCV+RRAlhSVhuNPsCp.s.pcAccsVscVWcSCFsDTRPF-c	.............................................................................pcCpt.hphhlp..s.P..h.l+ahhpt..lcp..hu..........ss........hppppltCc...................................Cssp....................huGG.F.ss....................ptsIllCpNp.h..........................................................+sptcl..ccslsHELlHAaDahRh..c.lDW....pNl+HhACoE.IRAus...LSG-CpahpE.hh.+t.tht.....lpp..........paQ...pCV++RAlhSlhu.s.ssCp.........p.tpApcsVscV...a-sCasDpcPFs.......................................	0	83	133	195
+9601	PF09769	ApoO		Apolipoprotein O	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4798)	Family	Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL [1].	23.90	23.90	23.90	24.00	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.57	0.71	-4.52	36	346	2009-01-15 18:05:59	2007-07-30 13:28:07	4	5	224	0	212	323	0	151.40	23	63.87	CHANGED	hh-ccsstts.h.spphsh.....sspp.p.................................hsscssshLppthpphRhtltpthshsps...........thsshhsphhstccphpsshssLtsssps...lLPshhaIlluuluGsIluRpRuhhhRhhhPlshussuhshhhPpo....hcssuphhashEccthPsls	.............................................................................h.sppls.lhss......sttp.c.............................................hs.psss.LpptlsphRphhtshhshsps...........ths.pshsphhsh.p.t..hpsshs...Ltsssps....hhPphshIsluuh..sG.....llu...Rp...tuhhh+hshPhshushuushhhPtp....hpssuchhaphtpp.hssh...................................	0	47	90	156
+9602	PF09770	PAT1		Topoisomerase II-associated protein PAT1	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4592)	Family	Members of this family are necessary for accurate chromosome transmission during cell division [1]. 	25.00	25.00	25.50	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	808	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.62	0.70	-13.55	0.70	-6.30	17	499	2009-01-15 18:05:59	2007-07-30 13:30:45	4	8	240	9	328	497	1	425.60	16	81.25	CHANGED	MSFFGFDoohPtcptstst.tt..p..............................h.Fp-TYcG.LG-p.pE-sDshND-TFGssh....slG+DFDFtstpuphsts.tttt.........tsutss.tstsphs..................psppsshpttpssp.hscLpshsulWu...t....................tssttspstPpssststp.lphpthpt.h..........tt..t.st.s..shs.shsst...t.h..........h.sshsttas..ss..................tph..tst.t....tthsh..PsphPs...tht............ph.st..tsst.ptt............pttsPPht...ts.P.t.sp......tt.ssh....t.p...........................................tp.hphspppchshh.cc..................t++hp+pcchhth.......tKasGLMTPpDKsFITRlQLoQlV..........o--PYsEDFYaQVap........h.ttstppsppstsphApsYL.poGpR..........tt+h+pu-sshQRMQQQVp+AVp.............ts+t+sKtsphhh....EGuLGKIShu.suKsPRp.L....shcpspssp..........tt.pp.ssphshpc.........................................t+KpILphlEslYpplhclEshpRshs..................tth..hptchps.sppLWpsL+l....ps.ssss.p...........spPFIuhLSasKGhKllPRlFpalscEQcl.TllohIhspLspLsVlhpu...ss....Phhsh.........pcth-..hFptslhsslhsalsps.sat.lhuLLshllp.psslshlupo+IGLullThLlSRAEll+ps....u.ss...........upp-hppWsphashLFssL..s..lsslFPs.............s.ststptYl.....................WQFL..Aululuup.ppQphlV.tV+DclhtTlspuKpl.s.......................hhtppplpNlNLFLpshGLssc	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ssLGpl..s.s...tP+..l.......ph......t............................................................................................................t..hh...........lEthh..lhph-t.....p........................................................tth..thth.......................................................................................hhthhth.KGhhhh.Rhh..l.........t....t.h...hh.h.hh.th..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	84	140	233
+9603	PF09771	Tmemb_18A	Transmemb_18; Tmem18A; 	Transmembrane protein 188	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4606)	Family	The function of this family of transmembrane proteins has not, as yet, been determined.	25.00	25.00	25.60	25.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.56	0.71	-4.15	5	136	2009-01-15 18:05:59	2007-07-30 13:31:49	4	4	93	0	68	120	0	113.90	55	84.03	CHANGED	hEPS.ACEDLKAFERRLTEVIouLpPoThRWRIlLslhSlhTuluAapWLsDP....cTppVPhh-S.LWsHPhFTlSslsLllLF.lhGIHK+VVAPoIIAuRCRoVLAEFNMSCD-TGKLILKPRPpNssp	..................t......sE....DLKAFERRLTEhlpslpPuTtRWR....hlLlllSlCTAhGA.WpW..LhDP..................cTppV.sh..hpS.LWsHPhFTlSsl...TLlsLF.hhGIHK.RVVAPSIIsuRsRsVLu-aNMSCD.-.oGKLILKPR.....s................	0	23	28	50
+9604	PF09772	Tmem26	Transmemb_26; 	Transmembrane protein 26	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4610)	Family	The function of this family of transmembrane proteins has not, as yet, been determined.	20.20	20.20	20.70	20.60	19.30	20.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.02	0.70	-5.19	10	150	2009-01-15 18:05:59	2007-07-30 13:32:27	4	2	77	0	112	137	0	235.10	35	74.38	CHANGED	llshLpAllTRlLFhlHulVuVWpVshlK.c-shYWhLslsllLLslEslhTlhh+KGcEaKWFsPSlFLYLsoIlPulWlLElchlpp+.............................sshucshcs.tpLhusluls...............httlsscsWstsLEQsLlLlLIlGRWLLP+Gc.lTRDQLSQLLLsYVGsAADIlEFh.-olKEspVt.....sNstlVhulLslWoWShhQFsLVLosTtsptscsusptcst.p........shhsphssDlWuIhlslllQDGPFLllRLlLhshacVIspMhlFFTsKNsLVllLQLYR	.......................................................................hhpAlhoRhlFhhHu.hlslWpVs.h......p.pp......haWhL....hh..hhL.hhEhhhTlhh+.cspt.....a......+WFsPulhhYL.sllPulWlLEhc..pph............................................................................s..p.p.t.......h...t.t..tht................................................lstpsWhhhlcQhhllhLIlGRWLLPh.Gs..lTRDQLSQLLLhalGsAADIlEFh.-ohcpp..pl..t.....pp.hllhhhLslWoWShlQFslsLssp..thh.....s.ht.ttt.............................s.p....hsh-lWslhhslhlQDuPFLhhRLhlhh.aplhs.h.lFFssKNhLllhLphYR...................................................................	0	52	61	89
+9605	PF09773	Meckelin		Meckelin (Transmembrane protein 67)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4611)	Family	Members of this family are thought to be related to the ciliary basal body.  Defects result in Meckel syndrome type 3, [MIM:607361], an autosomal recessive disorder characterised by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Joubert syndrome type 6 [MIM:610688] is also a manifestation of certain mutations; it is an autosomal recessive congenital malformation of the cerebellar vermis and brainstem with abnormalities of axonal decussation (crossing in the brain) affecting the corticospinal tract and superior cerebellar peduncles. Individuals with Joubert syndrome have motor and behavioral abnormalities, including an inability to walk due to severe clumsiness and 'mirror' movements, and cognitive and behavioural disturbances [1][2].	25.00	25.00	27.70	25.10	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	853	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.53	0.70	-13.40	0.70	-6.77	7	200	2009-01-15 18:05:59	2007-07-30 13:33:13	4	7	106	0	140	197	7	504.90	26	83.21	CHANGED	P.uhtspsspC.ssshhshhhssuCs.splhpuh.hshssssssshps.ssssh...s.hs.phsu..hhph..suAs.phhhushoACphLuNhCVh.hashsu...ssCtLapplhpst.t.........hhpthPhLaYucssshhp.l.sshshshphshttp.....LphlsusYDlcGshlthpslt.p.lpLCspssschpshashGsshphsCplshpcLl...tptspshFa-lalp..tsspchh.hslsh.hpshphpstphppsp.........................uh.phhhpRRhaLhDslsts+cts.p..........ppPphlpsspplplsh.lsspsppcplhsPllhlpYush.h....................sssphsshohulp...aphspssh..lhh.lshslhssLshhsuhhRThsWhRRpts.....hlshtslh+FhlahsscluNhFhhhshhsuhYhhlhaKhQpss.hhh.....spp.hhhpshlhsAhAhKulthLhclhpQsshDhFhIDWERs+uphhtppch.................sPVShWRohFVANEhNcLQslRphsPLhphhhlLFFL.sLsa.phu.psP.sott.sh.shs.s...hLRhuLsohhalhluLl.hlhchthahRFh..pPlppFVDLCSlSNISlhlLs-ppaGYYIHGcSlHuHuDssME-hppNLphEups.hs.RGLsspo...csQTaplhhs.phRpah.hhh.p.ptcpppu.h+t.ts.t...........hshppp.psYsshshhlpshIscsh+.shchh..h.hsK.hhcphLshtPs.hhhps.tp................sthslFahD-shuaupshhhG.-hsLhlh.hhlasslDluspNhhlAhslsaslphlh+ahRhp.GhtNlSpKTLID-RFhI	..............................................................h..............................................................................................................................................................................................................................................................................................................t.h........................C.................................................th.h.........................................................................................h.h..........................................................h.+Rh.hhpt..........................h....ph.h..........................s.h.h.h.............................................................h..............................................h.h........................................................h....t..s.h.h............................................h..hh......h..ht.h.hh..hh.....phFhlDWEp.c........................................................................lshWR.hhhANta.clp.hp.hs..hphhhhhhhh.hhth............................................................h..h....hah.h.hh.hhh...hh......p.h.tpFhDlsshuNlSlh.h.p..aGaYlHGcu.hshu-ssh..........ph...h..........tts....RGL..tt........p.psa.h.....hp..h..........................................................................................hh.thh...................................hth...........................................................................................................................................................................	0	74	84	118
+9606	PF09774	Cid2		Caffeine-induced death protein 2	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4613)	Family	Members of this family of proteins mediate the disruption of the DNA replication checkpoint (S-M checkpoint) mechanism caused by caffeine.	25.00	25.00	26.80	26.70	20.50	24.50	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.03	0.71	-4.11	22	228	2009-01-15 18:05:59	2007-07-30 13:33:41	4	3	202	0	153	219	0	140.50	30	83.25	CHANGED	Chs.stlcshLRh.Rp.lDDpIpppLNshhsssp............t.p.................t.ttCpphhcp.LhsuWpsRscllpaCtshusp.c.cssp............tpssptpcpthspRlDPYus+thpcE.pt.....psltphlpsEcsVEpIIRpRThplls-+Cth..pshp	........................Chs.tthp-hL+hhRs.lDDpIhppLNshhssup...hshc.............................sssppCcphhcp.LhsuapsRsclIphChs.ss..................................tpstp.+-ch.cpp.Dshsh+thtcE......................psh.hphlpsEhsVEpIl..psRohclhp-RCphp.p......................................	0	44	74	119
+9607	PF09775	Keratin_assoc		Keratinocyte-associated protein 2	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4615)	Family	Members of this family comprise various keratinocyte-associated proteins. Their exact function has not, as yet, been determined.	23.50	23.50	24.20	40.00	21.90	23.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.61	0.71	-4.60	8	113	2009-01-15 18:05:59	2007-07-30 13:34:05	4	2	96	0	73	121	1	122.90	45	90.56	CHANGED	MAVsouTShsLSolLhhLlFusMQMY+sQLASSphhTIhGGFLGSLLFlh.LTAluNlEsllhG+GFQsKlhPEVVlshllALhAuGhVHRVClTTCLIFSlsuLYYlNKIS.phat...ssslstssspKpR	...............................uoGsShhLSuLLulllFushQMYpppLASoEhhT..IhGGhLGShLFlh.LTAhsNlEphlFGpGFQsKlhPElllsLhlALhAuGhlHRVClTTChlFShsuLYalNKISpphaps...ss.s.sh..ttt..tt.......................	0	22	34	52
+9608	PF09776	Mitoc_L55		Mitochondrial ribosomal protein L55	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4616)	Family	Members of this family are involved in mitochondrial biogenesis and G2/M phase cell cycle progression. They form a component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.	25.00	25.00	29.90	28.70	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.31	0.71	-4.50	8	98	2009-01-15 18:05:59	2007-07-30 13:34:58	4	3	79	0	60	104	0	110.20	39	80.83	CHANGED	hLplLppsshpuss..s.p.hhsoshRssusRASloRl+RpsYuRLYPlhLVpPDGSTIpIRY+EPR+llphPlDL-sLSPEERRARlcKR+P..+pKlchp-El-DsFDsc+YhpFh.....+K	.................................h....................phhhsshp.hsS.s+.AuloRl+RpsYsRh.YPslLVpsDGSTIpI.RY+EPR+llt...hPlDLssLS.EE....R+sRLc+Rcs..p..p.K.hc.h..p.p..El..pDsFcsc+Yhpahp+...........	0	18	22	41
+9609	PF09777	OSTMP1		Osteopetrosis-associated transmembrane protein 1 precursor	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4617)	Family	Members of this family of proteins are required for osteoclast and melanocyte maturation and function. Mutations give rise to autosomal recessive osteopetrosis [MIM:259700]; also called autosomal recessive Albers-Schonberg disease.	18.90	18.90	19.80	19.60	18.40	17.50	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.19	0.70	-5.20	10	112	2009-01-15 18:05:59	2007-07-30 13:35:37	4	3	86	0	64	112	2	211.00	35	74.45	CHANGED	CpcLLtpFusspuchssChshpuhPV.+LCps..ChstYcsLpsh......YsNlpus...........................stpCucslLsSDRlplVsTlpshLss.lWppANC-sCls........pt..shsNcTtpFhshhsphhsChcp..p...........Nto-lCcsCKssYpcLNchYt+l-Kh.........ss..clClDlEDuMNpTRpLWS+TaNCs..Cp-sVs....lIAVuuhlLhLPllFYloSalpocpKc........R+LIhssRhpSssutsslp	....................C.thl.phupttuchhtChspt.uhPs.....plCps..Ch..atphhph......h..ssltps........................pstsCsc.lh..sD+hplVshlp.phhss.hWppAsCssCls.......................................ppt.t.....hoNsThhFhsh..hsphhsChpp...............p................s...............................Nh....oclCpsCcpsYpsLsshYp.chp+.hs.................ss..plClDlEDsMNhTRpLWS+sasCs..pscsVs.....lIAVushlL.hLPllFYloSalpocp+c..........RcLlhspphps..................................................	0	23	27	46
+9610	PF09778	Guanylate_cyc_2		Guanylylate cyclase	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4621)	Family	Members of this family of proteins catalyse the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate.	28.10	28.10	28.40	30.60	26.60	28.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.40	0.70	-5.15	10	169	2012-10-10 12:56:15	2007-07-30 13:36:51	4	4	106	0	89	157	9	174.60	40	78.21	CHANGED	VPHlpQtYsWDCGLAClLMVLctlshsspp..t-FpclCpc.thTpSlWTIDLAYLL++FuVcHpYaTpTlGANPsapscoFYK................cphssD.sRVspLFpcAcssGlsVcpRSVohpEIppHLtsGp.lAIlLVsAslLsC-lC....Khsh..shsptsasppscYpGHYVVlCGYDpssscFhYRNPAsSD.+lC....psShcsLEcARKSaGTDEDILLIa	..............................lPhlpQhapWDCGLACshMVL....phh.t..p.t.....phpph.hp......opS.lWTlDLAYLhp......+a............uV..p.apahT.TLG.ss.sYpspoFY+................cphsp-ppRVspLFtpAps.st....l..l.ppp.o....lohp-l..hLhput..hsIsLVstshLp..................p..h......h.....t.hst...p......ssYtGHalVl...pGYstss...tp................h.hpsPu.sc..php....................phs.psh-pARpuaGTDEDllhl........................	0	32	49	66
+9611	PF09779	Ima1_N	DUF2349;	Ima1 N-terminal domain	KOGs, Finn RD, Sammut SJ, Eberhardt R	anon	KOGs (KOG4623)	Family	This domain occurs at the N-terminus of the Schizosaccharomyces pombe inner nuclear membrane protein, Ima1. Ima1 interacts with other inner nuclear membrane proteins [1-2].	21.30	21.30	21.30	26.70	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.19	0.71	-3.66	12	204	2009-01-15 18:05:59	2007-07-30 13:37:26	4	4	167	0	144	192	0	120.30	35	19.20	CHANGED	lsCaaCspcot.shpst.p.WpC.pCEthNhhsEpG-..pD...Psttpsp.....pshtsssp.ss.p...........sspshFCspC.cNQplhhptLApa..hPss-cspYttY-cch.taR+pLEcpYPplCspCEs+V	....................................lsCaaCspp......o.hhsh..t..spsp.apCspC-thNhhpcsG-..ps...Psth.pph.sp.hs.ps.....s...s...tsssp..tt...................ssspslhCpp..CpcsQplhhppLAs..a..h.P.c.s.-s....................................pa-cclpsY++pLEppY..plCpsCpstV.............	0	46	68	110
+9613	PF09781	NDUF_B5		NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4632)	Family	Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol [1][2].	25.00	25.00	51.20	40.70	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.26	0.71	-5.01	10	143	2009-01-15 18:05:59	2007-07-30 13:39:22	4	2	98	0	69	136	0	164.40	44	97.25	CHANGED	MAuMSlL.puuAuhsApLsslhpussttsslppslsts+ss.ush.auGsHG++hFsIpPS+FYD+RFLcLL+FYlhLTuIPVushITaVNVFIGpAELAEIPEGYhPEHWEYYKHPITRWIAR.laDSPpK-YEKhLAhlphEsEKA-hRhhEtEVR+hM+ERGDGPWYaYcT.......l-KEhlDcu.KATPDs	................................................................................h..........th....p....t......h..s...tu.HG++hFhI+P.Sp.a..c+FhcLh+FYlh.LssIPVshhlohlNlFl.GpAELAEI.P................EGYhPcH.WEYaKHPIoRWIARhhasSPpcpYE+thAhlphEsEKAcl...RhhEhcVR+hMppRsDh.haaYps........lsKphhDp..c........................................	0	19	25	47
+9614	PF09782	NDUF_B6		NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4633)	Family	Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol [1].	25.00	25.00	31.50	28.10	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.03	0.71	-4.37	11	120	2009-09-11 15:31:47	2007-07-30 13:40:18	4	5	86	0	65	126	0	126.40	38	83.66	CHANGED	hoGhpP...............DE+lRLptL....RphR+pWLKDQELSs+EPVlsP....cphsPIc+Fapp.L-p......pssathhhhpsYRhslhplshlLlshahsHYYhKYcss......ppsatllppKsplhPG.......sslhEpG.s.Ps.t-assppa	.................hsGhpP...............-E+lRl.pt.l....RphR+pWLKDQELSs+EPVlsP.......pths.Plc....+Fapt.Lc..p.........pssat...h...hh.htshptshhthhhhLlssahhaYYhKYphs......................ppsa.tllpp+.tlhPG.......spl.-pu....s..t-h........................	0	19	24	49
+9615	PF09783	Vac_ImportDeg		Vacuolar import and degradation protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG5073)	Family	Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole [1][2].	20.70	20.70	21.50	24.10	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.34	0.71	-4.78	20	333	2009-01-15 18:05:59	2007-07-30 13:41:13	4	8	229	0	222	328	0	167.60	39	52.54	CHANGED	saLcsGspFpGpQpS.............ppppYpVcVpIcsVDht.........psaLsGaLpIpsLTs.paP....plTTaFEGEIIs.....................scasFhTp.......cWsAsp.........csDlpHWt+FPuF.+slsptttp.......................................tphpht-h.spcalFMRWK.EpFLVPD........tpl.cslsGASa-GFYYIsasp.....ssGsIpGaYYHts.uEpF..QpLpLpss.p.c	...........................hLhsGtpFtGpQpS.............ctptapVpVpl...ppVDht......................puaLsGaLcI.....pGLT-..caP.................slTTaFEGEIIs.............................pcas..FhTp.......pWsAsp..................................csDhpHWs+F..uF.pt.htpph.p.p.............................................................................................sshp....hpchh..sp.palFM..........R....WK..E.p.F..LVPD........................ppl.+slsGASasGFYYICapp........................ssGslpG.hYYa..p.Scha..QpLpLp.s.sp........................	0	65	115	176
+9616	PF09784	L31		Mitochondrial ribosomal protein L31	Mistry J, Wood V	anon	Pfam-B_24102 (release 21.0)	Family	This is a family of mitochondrial ribosomal proteins.  L31 is essential for mitochondrial function in yeast [2].	20.50	20.50	20.50	31.50	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.54	0.72	-3.95	10	125	2009-01-15 18:05:59	2007-07-30 13:41:43	4	3	122	0	100	120	0	106.30	53	91.26	CHANGED	TpPlhGGLLWKlPWRhSssQKtRQRcRLRuVD-VlcsLs................puLp.h+.sp..spppl.+hlsp...hPpEppMSPKDK.......................YTsFsKKs.....+GYRKGIHKVPKWT+lShRcNPptF	............Tssl.GGLLWKI..P..WRLSshQKsRQRcRLRsVDpVlcsls.......................pAL.t...+p....Gt......stcslpRh..htc...hP+EpEMhPKDK.......................YThFD+Kp.....KpYRKGIH...........KlPKWT+lStRhNP.GF..............	0	26	57	86
+9617	PF09785	Prp31_C		Prp31 C terminal domain	Mistry J, Wood V	anon	Pfam-B_7665 (release 21.0)	Family	This is the C terminal domain of the pre-mRNA processing factor Prp31.  Prp31 is required for U4/U6.U5 tri-snRNP formation [2]. In humans this protein has been linked to autosomal dominant retinitis pigmentosa [2][3].	25.20	25.20	28.20	30.90	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.74	0.71	-3.69	28	315	2009-01-15 18:05:59	2007-07-30 13:43:11	4	7	273	0	230	308	5	129.70	42	25.27	CHANGED	ss+hsKsLPhPp-.pspKKRGGRRhRKhKE+auhTEhRKhtNRMpFG....................ppE-shh..hspshGlGMlupssst.........+lR.....htphss+.........sps+hoKph...........................pppLpp.pstss..............GhsSSlsFTPhQGlEllsP	.....PsKtsKsLPsPt-.ts.+K..KRGGRRhRKhKE+.huhTElRKttNRMsFG...................c.E--sht..t-hshGlGhlGpsssG.........RlR................ts.plsp+.........o+A+lSKph...............................................pppLpt...pshtssshs..............................uGhuSSlAFTPlQGlEllsP..................................................................	0	78	130	191
+9618	PF09786	CytochromB561_N		Cytochrome B561, N terminal	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4670)	Family	Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterised proteins.	27.30	27.30	29.60	27.60	25.60	24.20	hmmbuild  -o /dev/null HMM SEED	580	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.78	0.70	-6.06	9	196	2009-01-15 18:05:59	2007-07-30 13:43:26	4	6	121	0	107	172	0	407.90	32	88.01	CHANGED	pss...........psPhlspslshphpptppphhLhhsllsl....ulluhlhh-hshpshhsahsl...shahhthslsulluLsslhs......aspaF+hlh..................sp-plshostQppLLu.lcspspt....ssupsspp.stspsphPsssSss.lph.p.shstSstpStSsu.hhosssssthps..ps......................p..u..s...s.uasosl.s.psSsstspht......SPhuhpp.sspcDhhT-p+hL-paLpphcc...phppussspsos..p.t...sousohhstupsssshupslhpp.hph...Ssuss.s+pchshssKchpu.......h-su.Esht+lu.....hsplppapupL..RtWlSpTlLpPLVpcIcoscpph+ppus...sslpIGplu................................lcpL+psA....................t.phps.hhPhLPhlh.aLDshoNQc.......................YLVpRIKELAcGoClssY+WsuGushpGc...........cWspcLPTDSsllhaLFCsYLD...............oQLsspPh.sG....scsFss+YlllsssKPsstp.......stAhslhlss.sP..PpFshla.D++la....sshpsRsNLFcsll.FlahlKscpsGhlcslNLGpSulNILsll-s	...................................................................................................................................................ss.............ltt.h.....t......lhhh...h......hsh..h.c........h.t......h.....h.h..hh..hhsh.hlh.......h.thhh.hh........................t...h.ho..p..hLt.h.............................................h........t.s...t..........................................................................................t................s......................ss....t.....tpth...t-.t.L.phhtt.pp.................p....................ss.hs.........st.ht..h.hh.hph...u.s.....p...pp.............s.cp................ts.-sh.t+ls......hsphppahsph...R.............Wlspsll..Llpclpphst.hpphsh.....pl..pl.G.psu.....................................................................................lppL+thh.............................s.lshl..h..L-hhspp.p.......................YlhpRl+-LupGsChs.sacWstGu...shpsc.........................pWs.pcL.PTDutllhHlFCsYLD....................................upL...sp.P.h..s.........s+sFs.spahh.ps.sc.sshhp...................pp.shh..lh.ss..s..P...P+apllh....p..c...clh.........ph.pGRsNhFcsllhFlahl+ppptGhlttl...slG.uulNlh.lh.............................................................................................	0	39	53	85
+9619	PF09787	Golgin_A5		Golgin subfamily A member 5	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4677)	Family	Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterised: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1 [1].	30.00	30.00	30.20	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.82	0.70	-5.98	16	253	2009-01-15 18:05:59	2007-07-30 13:43:51	4	5	110	0	149	263	0	354.90	25	75.37	CHANGED	-N..................ElspLsQstAollptpptsp-.p............p.s...s....................................psNpusucspKhsscp.........sppssoohpLsutscshspssusps.......pLAslKltLpEhstElcph+ppL-sh.ppcsp.hpscpcsppLppttl......coLp-+Lp-t-sslppcppshpptphtFlc+lschEh.hppLt.t.s.A.R+hscchpchs-hppplclh+ttscspctELhcY+.+Ap+hLQsK-KhIspLKptshhpuhp.t.ss.............hEL-ph+cEppp.p-ElppLptQIpp.h.EhpDhcsctsupscph+cpspclppthtsphoo....-s-.thhppEhtahcEshtpppsshpsRlp-R....psEhQplRspLos+s.psSu.s-lEsRLpsLTpoLlp+QshLE...pLosEKNuLslQhERlpp.L+t.....t.pssssopl.hphls.s-Ds+tR.lPlhhppssh-l.thht+h++AhpsIDshuIRlGhFLRRYPhsRl.lIlYhAlLH.....................hW	..................................................................................................................................................................................................................................................................................................................................................................................t.ht.............p...t..................p..h.................ht.........htt.ptt.hpt.h..............p.h...p.pt....psp.pl.ttt.............................poLpc+hp.h.cttlthp.ptphh.h.....aht+h.......p..h.c....hp.Lt.t.....A.....p.p.hhc..hp....chs-.....p..lchh+h.hcptc.tL.pY+...tph.lps.-ph.hp.LKp.sh................................................h...........tp-.th.p..-phphh.hQ..l.....ph.pphp....p..t.t......p..pp..pphp......htt.........h..pph..hp.pt..p.tsshp.php.+.........................-hphhhp..tlss...ps..p.p...s...p..-......l-........thhpp.hs.............................ls.h.p+pth.hthc+l.p.hp...........ttpts..s..p..h...th....p..s-..s....sc.p..h....shhhp..p.h.....sh...................slDp.h.........R..hsR..llhYh.hlp.................................................................................................................................	0	48	60	105
+9620	PF09788	Tmemb_55A	Transmemb_55A; Tmem55A; 	Transmembrane protein 55A	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4684)	Family	Members of this family catalyse the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.	30.00	30.00	30.20	30.10	28.60	27.00	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.16	0.70	-5.25	7	173	2009-01-15 18:05:59	2007-07-30 13:45:18	4	3	87	0	106	163	0	224.80	49	91.93	CHANGED	M.ADs..ERSPLLScspcGs.....s..u.sst.ht......sstP...tshsPhs....ss.h.uE.PPPYoshsSP-ouosPslsCRVCQSlIsl-GKhHQHVVKCslCNEATPIKNsPsGKKYVRCPCNCLLICKsTSQRIACPRP.CKRIINLGPV............p.uPsoPss..QPtGsRVhCGHCusTFLWsEhpspTL......................ARCPHCRKVSSlGptaPR+RslhhhllsllhllsusGLh...........................sGThphAppatGlYsuWshhllLsllsLsRuhYWhsh+lS	...............................................................t...........................................................................................tt.s...............sE.PPPYs.s.........tS.sss..u...uh..PhlsCRVCQuhIsl-GKh+........QHVVKCshCNEATPIKNsPsGKKYVRCPCNCLLICKsoSpRIuCPRP.C+RIINLuPs..........................p.tPhpPt....pP.t.usR.VhCGHCpsTFLas.php.p....o..L.......................A+CP.H..C+.Kl...............SSl....G.p.tasR+RshhhhlluhlhhhhuhG...Ls...........................hGThph.Appat.u.hYsuWshh..hL..lullhLhRuhYahsh+VS...............................................................	0	28	37	70
+9621	PF09789	DUF2353		Uncharacterized coiled-coil protein (DUF2353)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4687)	Family	Members of this family of uncharacterised proteins have no known function.	30.00	30.00	30.00	30.90	29.50	28.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.23	0.70	-5.17	4	117	2009-01-15 18:05:59	2007-07-30 13:45:48	4	2	80	0	70	102	0	264.50	45	66.32	CHANGED	+pKLpSKs-ALhILtp-LEpsppERDtaKhhscpLp.chpshK+p.pEhph.shttGc..h..tp.............................+ppsLupLlpcsR-cNppLss-hp-L+pphtElptDhclLRpslsc.csuhpthsspcph...........cp+pcLlppL...E+h+cKsptLEpDl+SlhDEKp-VshERDtappKupRLNsELsalLsuDpp..Rll.DlDuLlhENRY.+p+lspLcEEhphh+tslsKYKshhEs.Kpppshl....KsG...ssspsuVhutKQV+-LLtSctsc...thslpstohS-L+uLssuLL-sls-KshALtHQ+psNKlLGsRlsELEpKltsL	.........................................................M.AppLp.RapsLK+p.p-h........ts.......p.............................ppssLupLLp-op-cN+pLspElcpLpQRLsElQGDsK.....LLRhTlA+p..+lsc..p.pl.u.s+..phs...................tHERE-LVpQL......E+h+cphcpLcaDLpuslDEhp-lppERssYpsKscRL...NpEL...salL......uGccs............RIl.DlDALhhENR...YLpERlpplpEElpLhKpslsKYKs.hL-t.K...pp..Ks.h..........................K.t...soshssV.LSsKQV.....pplL.Spt.t...sLPhpspoloDLKSLssALLEslp-KNhslpHQ+pTNK.ILus+lsELEp+lptL...................	0	19	25	50
+9622	PF09790	Hyccin		Hyccin	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4688)	Family	Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterised by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs [1][2].	25.00	25.00	26.80	25.20	23.00	23.70	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.93	0.70	-5.57	12	234	2009-01-15 18:05:59	2007-07-30 13:46:59	4	4	110	0	141	211	0	266.40	36	61.63	CHANGED	spsphsshAssLppctulssAlapllpc..stu-Ll-PlC+QLa-hYpSsE.pLphFsLQFlP.LlahYLptssucc.p...usushEAlLLulYNhEl......sccGsuKllohpIPsLSpPSlYHEPps...hsho-suhtpp......................sh.+sVhSush.pp-slpAQNRhcllshLLhsYNupls.MPtsShhp.lCphsuplsspGa..........................tpt.h.......Rl.lsspFhlp.hpuhaaAhhNG.hshu.psl-slh.RAphEhhscslLluNuhctSL.tuu.spsc-Gphsl.hElp.ss.R....IsppslTuhSlRs++hpcc	..............................................s..sph.phAtsLhpctsl.h..s.ulapslpp..............sts...cLl.-PlC+QLa-hYR.S...u-...pLpp..FsLQFLPtLhasYLthssucshp.....................Ssu...slEAlLLulYN...hElh........................cccG..p..s...KsloFplPoLSp..PS.lYH.E...Ppsh.....hshT-sshtpc......................sh.+s..Vh.Sssh..pp-thsApN.RhcllshLhhsYNu.tlshMPssSh.s.lCphso...pl.sspG...a................................................................................................................tpp.h...t.....t.ps.Rl..ls.s...tFhlphlpu.l.aa.Ah...a.N.Gthp...hu.psl--l..hhRAphEhhspslL..Vs..NAhcsSL...s.s..tp.sp-.G..t.hslps.t...ls.ss.+....lsps..slTshSh+t++h.cc...................................................................................	0	34	58	95
+9623	PF09791	Oxidored-like		Oxidoreductase-like protein, N-terminal	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4690)	Family	Members of this family are found in the N terminal region of various oxidoreductase like proteins. Their exact function is, as yet, unknown.	20.40	20.40	20.50	20.40	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-8.70	0.72	-4.52	26	419	2009-01-15 18:05:59	2007-07-30 13:47:32	4	11	343	0	263	401	6	45.70	35	23.27	CHANGED	+sIAGVsVPs+Pp..EPDNCCMSGClsCVW-hYpDDlc-Wsp+pcpApp+	..............................P..pP....-..P..s..s..CChSG..C.s.s.CVa-hYt--L.pcaptthtth...t............	0	75	132	207
+9624	PF09792	But2	DUF2295; 	Ubiquitin 3 binding protein But2 C-terminal domain	Mistry J, Wood V	anon	Pfam-B_45554 (release 21.0)	Domain	This family is of proteins conserved in yeasts. It binds to Uba3 and is involved in the NEDD8 signalling pathway [1]. This family represents a presumed C-terminal domain.	24.20	24.20	25.00	24.30	23.80	23.50	hmmbuild  --amino -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.79	0.71	-4.43	24	100	2009-09-11 16:53:07	2007-07-30 13:48:38	4	4	66	0	84	103	0	143.10	32	44.30	CHANGED	apFPHLIlPlcSouPspuhGTsasGpVoss......lSoIFNFDlPsu....sucoCoLsFhFPp.cth.susasFsGsGphsFspL...susssssTTasNsPshtpcluphsloP..GssYslso.FsC..PuGp..sluaEMssuGs.TpLsa......FpDasPs	..........................hpaPHLIlPlssssPspAhGTsasu....pVoss..........lSoIFNFDlPsu....sucsCoLsFhFPppp....th.ts..ssasFsG.......s...Gp.....lsFspL........suss.sssT.T.asN.tP.....ss..ppc.h...Gs..h.slsP..Gpuasls......o..FsC...PsGp..sluachsssGs..TpLpaFpshs....................................................	0	26	45	69
+9625	PF09793	AD		Anticodon-binding domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4401)	Domain	This domain of approximately 100 residues is conserved from plants to humans. It is frequently found in association with Lsm domain-containing proteins. It is an anticodon-binding domain of a prolyl-tRNA synthetase, whose PDB structure is available under the identifier 1h4q.	21.70	21.70	25.10	22.70	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.01	0.72	-4.14	29	270	2009-01-15 18:05:59	2007-07-30 14:02:34	4	6	225	0	189	258	2	89.20	31	42.44	CHANGED	sssslslpplppRhppslppt.........pppttphGtuVo.-uQplF-slt+T..hstspWsup....sIlVh-.-VpIssP.Ypsss.sp......sssspuhs...pVpKl	................................................lslpplppRtcp..slcpt.............pppttthu.s.GVS.E..uQplFcslpKT...hs....s+Wpsp....sIlVhc....cVhIssP.Yps-s..sp..........ussssu.ls....+V+Kl.........................	0	63	99	148
+9626	PF09794	Avl9		Transport protein Avl9	Mistry J, Wood V	anon	Pfam-B_12001 (release 21.0)	Family	Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo [1].	21.30	21.30	21.30	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.35	0.70	-5.98	23	380	2012-10-02 14:18:06	2007-07-30 14:08:51	4	13	238	0	281	533	2	300.40	27	50.61	CHANGED	lhtlsVVDFHHp+GP.................clEahas.......tpspttsshWp.LPF.ALPDGuHsapE-FoaFsLh...................ssspstpTlFGlSCsRQIcuscL....hpRssDVTRSTVQKAVVVlucpP.IFG.l+-KLSllTpAaFtQcDFospcILcpha-sLpsp.hpshsspp......................tpsc.........halGL..sLRcllh+FR+phLlLaKhlLL-KKllhau.ssVEtLsshQhullSLlPsLlsp.LpDsu.......................................................................................................sPhhcshcps..lspssShcoSsRpS................................................hLcahGhPLpIFs..................+GuhasPYhPLQQlchL......ss.ss+uallGoSNsLhhpQ+cph.sDlll..........slDssplphh...sspLcphLpLSstD++ahDhllppVppshc-sp.pt............ta....................GS--aIRhQFE-YLhuLLSos	......................................................................................................hlhlVsFchthG..................tlEh.as.................tt.....pthp.lsahAhPDu.sHs..................t-..-.h..a.F.pL............................................................................s..t.ts.ttsl..aG...h.u..C..hR..Q...lc.s.p..tL.........h.+...-...lT.R.uhV.Q.K...u.lsl.....l.........uc..h...P..ha..uh...l.........p............t+Lp..l.lsp.s.aFtp.....t.........ph..t.p.h............p.l..l..h.pth.............................................................................................................hhsh....s..p.ph...l............p...ap..p.h....l.hl.hKhh...hLp.+h..................hh..h.......h......t...........h.......s.h..shh...ShhPt.hh....h.................................................................................................................................................................................................................................................................................................................................................................................t.hth.Ph.lF.t..................p.s.h.h.PYh.sL..hp.l...............................h....ahhGso.N.lh.....pptp....-hhl..........phc......t......t.......l.h.....p.tht..h.....o..Dh+a.hp........lht..h.....t...................................................Gu-talR.pht.Yh.thlt................................................................................................................................	1	105	148	233
+9627	PF09795	Atg31		Autophagy-related protein 31	Mistry J, Wood V	anon	Pfam-B_60001 (release 21.0)	Family	Autophagy is an intracellular degradation system that responds to nutrient starvation.  Cis1/Atg31 has been shown to be required for autophagosome formation in Saccharomyces cerevisiae [1].  It interacts with Atg17 [1].	25.00	25.00	92.10	88.90	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.07	0.71	-4.53	5	24	2009-01-15 18:05:59	2007-07-30 14:14:04	4	1	23	0	13	20	0	177.00	53	99.48	CHANGED	MEs...TlTVYD+Nltaphpscc.............hhssht.S.pGuspoMFPTNIKYIFEDDDDplsDss-h......pp.ss-lENVIIV-LDsoGoLENVELISDpYELLSF...p..pL.p.t.ho..pcuNDpsND........................IEL-VlSEF.sDLSss.o+DLuLD-LlKlYspQNcQL+plSDoL	....Mss...TVTVYDKNV+apL.cEN.pp......s..sthsscS+Ss..DGuchAMFPTNIKYIFEDssD-Ll....DooDt.........................splsD.ElENVIIVpLDESGSLEcloLISDQYELLSa...pphSLppNp.+ohsS+u-D.+uND........................IELDVlSQF.sDLSPh.L+DLSLsDLIKLYspQNEQLQhLSNSl.	0	1	5	11
+9628	PF09796	QCR10		Ubiquinol-cytochrome-c reductase complex subunit (QCR10)	Mistry J, Wood V	anon	Manual	Family	The QCR10 family of proteins are a component of the ubiquinol-cytochrome c reductase complex (also known as complex III or cytochrome b-c1 complex).  This complex is located on the inner mitochondrial membrane and it couples electron transfer from ubiquinol to cytochrome.  This subunit (QCR10) is required for stable association of the iron-sulfur protein with the complex [1].	23.80	23.80	23.80	41.70	23.70	21.70	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.87	0.72	-4.31	21	109	2009-01-15 18:05:59	2007-07-30 14:15:48	4	3	105	0	82	110	0	63.60	35	51.33	CHANGED	paushohpshp......pausthuhaGuuAushshhFhutlP+h+pDlhpKlPhhGsaa.p+pIsPEDsPh	............huulohpphh......pausthuhaGuuAuhsslhFhuslP+lpcDlLpKIPllG....p.aa.p+pl.sPEDsP......	0	19	44	72
+9629	PF09797	NatB_MDM20		N-acetyltransferase B complex (NatB) non catalytic subunit	Mistry J, Wood V	anon	Pfam-B_12009 (release 21.0)	Family	This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyses the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met.  In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1.  NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions.  This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1 [1].	22.80	22.80	23.00	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.08	0.70	-5.74	41	303	2009-01-15 18:05:59	2007-07-30 14:19:52	4	15	265	0	219	313	2	352.20	20	40.32	CHANGED	Wshaphhl......pushpl..................ppppsshtphp.h.p.ltt..................t.hsRsshLApL-lhthh..................ptpchtstlhp...YaccFtsKssCasDLppYl...tl....stp.phpphhpth.pt..........................ss.pphhpplsshcl....................................t..tthsppph.p........hhpphhptappshpht.pt...............p-hpsuD.chsLlusp.hllch..............pppts.phllpulslLEphlscsspNaphpLhLlplYhhL.GssshAhptappLslKplQh-TluHhlhsphsshtshstss............phhspshpaYpsspppssch.ltpuactssaspl.shhcFpc+LppShp+...hhhtl-phplptlh.ssphht....thpthsp................p..stpslsDsRDh	.................................................................................................................................................................atha..hh......tushph.............................t.t.pt.p.thp.h..p....l.p.......................tt.hhRsshLApL....Elhpphht.t............................p.ssh....phhhp...YapcFss.KssCasDLchal...thL........s.p...phpph.hpp.lht.h....................................tshpth.pplsshpl..................................thhh.s.......t..p..hs.tpph.p....................hhpphhtt.appshphs.ps...............p-h.p.sD.thsLlAsp.sLlchh......................tpsss.sh......l..hpAlslLEp.h..L..ppo..spNhph+LlLl+lY..th..L.Gshshuhp..ha.ppLclKplQhDol.u..ahlhsh...htshs.hstss.......................................phhpt.h......hp...aa.psstp.cssch...lhtuachssasp..........l.chhpa.pp.+LppShph.......hhsthEphhhphhh.tsp..t.........hpth...........................p.th.Dpcs.....................................................................................	0	82	125	183
+9630	PF09798	LCD1		DNA damage checkpoint protein	Mistry J, Wood V	anon	Pfam-B_41058 (release 21.0)	Family	This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1 [1].	25.00	25.00	38.80	31.40	18.30	22.00	hmmbuild  -o /dev/null HMM SEED	654	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.96	0.70	-6.53	6	47	2009-01-15 18:05:59	2007-07-30 14:21:43	4	2	43	0	29	43	0	601.70	32	89.65	CHANGED	MLRD+.................LphLppptcc-csppptphsplpscacpELpKL+ppLQ+LEDE+KFLlhEpRulssschps.....p.........p.h.ss-ussls.pupssus+p++cchp....hpphlsLs.s+llt..c-sSLFhD+lh.apIhGu-hosl-hLs+Iph-h.s-hss.cphlIsustPLGpuIpphLhphKpphpLDchVDpsLEsLAsLIKp.Ilhsp-spLulPFLlALMapslpFRsSAsSlpuLKDLF.FhsDLhhpFphlLKsPlHcSs.L-lclsPplFQYpllDpLsLhYSFDllEsshpl..l.ppssps.pphacE.hlhKsLhtshphsLTISaKsl..lNlIaShVEllhslssl...h..pssscslhssphWtslIo+Laplhp+plpsscla........hph..hhsFhGLpRshGsNssssLIcplIsppcl..........pulP........hlIp+-s.shst-s.....h...p.chEtWhlpL+pslssIhcpLlhpapcp.plsstEhLhphs+hlupEQthhhshhlstDopshthRhpLlphLlplIYhhWppapcplppphhh-sps.ELlhsLWRllasp.psps.tpp..h-hthLlsphcsLslcDppcha-Dsa--.sh.PtalcpELtsphsppstpthpspa-phhhEMA+pILES....hlohEEsDSLYluM	.................................hLRsp.................lp.Lptp+ccEhph.ttphpphphpc........pclstLKpplQ+LEDEKKFLp.Eh+stoppcht..p.....p.................tsh.sssspss..s....pspsp.......osps+p.pchp........tpshhsls.s+ll...c-oSLFh-plh.HpIhGuchoTlEhLs+lpl-.hschph...cshhIsKttslupuIsphLht.hKKshpLDchI-phlpslssLIcc..lp.p..-spLAVPFLluLhapslpFRPSAspp.sl+chhhhlCDLlphapalL+s....slc-ss..hshcstPp.hQhpll-hhllhauhDlLEtllpl..hppastphhhphacc...lhpsh.hshh.s.o.paKsh..lNVlashVEllsh.soh.........shs.s...ss.pphhstp...shIspLhtlh.h-l.st-sa........................................sFaGL.RslGsNp.sthIsplI.p-ch..........pulP................plI.c-s...hspsp.................lshphEtaLLpL+.clhslh-sLlhhhts.thlhstEhlhphs+hluhEQshhhp...u.cS.slclRhpLIpphlplIahlhp-p.cplpp..hp...-s..t.-LhhsLhRlhhspspts..........ss.s.cp.hh-h...Rph.sthppL.slp-p..sphhpcthpch....spahp...t...Ehhtplppchuphhph.Y-pch.EhARpIL-s....hsohEEADsLYhsM............	0	6	16	27
+9631	PF09799	Transmemb_17	Transmemb_17; Tmem17; 	Predicted membrane protein	KOGs, Finn RD, Sammut SJ, Coggill PC	anon	KOGs (KOG4694), (KOG4502)	Family	This is a 100 amino acid region of a family of proteins conserved from nematodes to humans. It is predicted to be a transmembrane region but its function is not known.	23.30	23.30	23.60	23.80	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.24	0.72	-3.72	24	272	2009-09-11 14:19:48	2007-07-30 14:25:56	4	2	110	0	190	264	1	103.40	28	63.14	CHANGED	hhLYhsshahshaalspllhhhhK......hhhhsshhhshtlshhllhsllEslRLhlGhtGNLpEcsstLshhhlLohhstlshlhahhhpshlLh..L-hslsslhlshhsh	.........................hhhahNshahshahlsplhhhh.hK.......h..h..h.s...s.h.h.....h.........hh.tlsl....lllhhllEslRLahGhp.GNL.s.......Echs.Lsh.lhLThsstl.h.slaaL.L.h.p..shlLp.....lEhhlsslhlhhhh.h..........................	1	55	75	129
+9633	PF09801	SYS1		Integral membrane protein S linking to the trans Golgi network	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4697)	Family	Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1) [1]. Sys1p is a small integral membrane protein with four predicted transmembrane domains that localises to the Trans Golgi network TGN in yeast and human cells [2].	21.90	21.90	23.30	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.77	0.71	-4.19	27	331	2009-01-15 18:05:59	2007-07-30 14:27:17	4	3	259	0	233	308	3	132.70	30	71.10	CHANGED	apps.hsPhhIlsQIlhLQshYYhshsllh.hhhstlsG.sho................L.-hlFsac............slchssshGhhlhhhalls.uLl................sslhLhhlVtRoKLsLDFAlTlHhlHLlhshlYo...pshPtshsWWhlplhusslhshlGpahChh+EL+sI.h	...............................................................................hsPhhIltQIl.hh.Qsh.aYhsh.slhh.hhhshl.hst.t.h.o...................l.chlFsa.c.................................l.ph..ss.s.Ghhhh.h...s.al.Ls.ulh................su.lh...Lh.h.llpRuKhshDFulTlHhlHLlhshhYs...tph.PsshtWWhlphsuhslhshlGpahCh.h.pELptI.h...........................	0	78	126	188
+9634	PF09802	Sec66		Preprotein translocase subunit Sec66	KOGs, Finn RD, Coggill PC, Sammut SJ	anon	KOGs (KOG4699)	Family	Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures [1][2][3][4].	21.30	21.30	21.40	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.03	0.71	-4.90	16	149	2009-01-15 18:05:59	2007-07-30 14:29:02	4	2	146	0	113	141	0	182.10	37	76.09	CHANGED	hphlSlhTPLlYlulLlsSLhsFSshYRK++hpchupLcPhFs-ptsRclYhsLtch.-s.........................+lp-KVlKAALLRRusEsIRRslKL+EtcstlshLappGSlGDDlWpRFppttKhhEhEl+-llpEApshtPsWsQohFtsApEIshNpALRRRhssIpsRscpptchW-h+hs..psuhhhp	.................................................h..hlSlhhPhhYlslLluoLhsFSshYRKR+stc........sp.l.tPaFss.ph..p....RslYhoLhchp.............................pls-pV..LKAALLRRAsEDI+R...llcl+ptKsulstLhQ+GSlG.DDlWpRFppAEKEhEtEl+DVltEANsht...P..uWGQhIFpoApEhsh.Np...hhRc+lpplppptppppchW-h+ts..pp.............................................	0	35	64	98
+9635	PF09803	DUF2346		Uncharacterized conserved protein (DUF2346)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4702)	Family	Members of this family of proteins have no known function.	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.73	0.72	-4.13	6	116	2009-01-15 18:05:59	2007-07-30 14:29:41	4	3	106	0	83	121	0	77.40	29	84.11	CHANGED	MGsWtLEluRMslYhTFPVAMFalFNQPEYFE-aVscpKRplaPPEpcpHRcclEchhcpl.....R-++-pcLL+thp.tEpKc	.........MGs.pLElhKhulYlsFPlu.haa.h..h..Nps-hF...c..c...a.lh.....p........p+cc.la.PP.Epp.........p..t..........c..pElp..c...htc.ch.....ppp..cc.pchhcth.......ptt.....................................................	0	34	46	65
+9636	PF09804	DUF2347		Uncharacterized conserved protein (DUF2347)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4704)	Family	Members of this family of hypothetical proteins have no known function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.87	0.70	-5.13	36	201	2012-10-02 14:18:06	2007-07-30 14:30:16	4	7	172	0	144	318	1	266.40	32	54.98	CHANGED	lFllpFDlKsGYslsWpcsh...sslpL-G.VEYKoLPSGlHpls-DllY.Fs........cc.ta.....hGlSsFhstsss.-ppR........ss+MhulGVLss.................s.thlspuWcasstLcphs.pphhpst....sshpsLppaa.....p..ph....tt..............................pttshspstshhsspphhsshHPshsLPphlcphGPLlFsLa+uuLLRKRILlh....sps.................PVctsCsa................VYslSlLSslPpslhshhssp....s.h.pPlFslGlpDl...shLtph........................uaIACToDpILthKscLaDlhVslssststpstt	............................................................................................................................................lFlhpFDh+.t.G.hl.Wp....hs...........s.....ls....L....-......G..V..Ea...K.....ShPS.....GhHplppDhlY.Fh................................cs..a.hGlusFhshss-.ctpR..........sA+MhuV..G.lLss..............................hsthaRahp.hLcphs.pphhps...........sphp..Lp...taa...........cp.ph..............................................................tht.s..h..s..sh..hh...t..ph.p.hHPshshsphlchFGs.IhsLa+.huLLRKRILIh....s.s.................................................PVt..sC.h...............................l.Y.s.h.....s.....hL.us.lshshhshh.sp........................+PhF....lsltDI....s..Lps.h.......................................ualACTT-cIht..KpcL.Y.DlhVshsssho.p.......................................................	0	40	73	111
+9637	PF09805	Nop25		Nucleolar protein 12 (25kDa)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4709)	Family	Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit [1]. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export [2].	22.50	22.50	24.90	22.70	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.20	0.71	-4.10	41	300	2009-01-15 18:05:59	2007-07-30 14:30:41	4	6	257	0	202	285	1	141.20	26	58.48	CHANGED	p++phtpp....scElsFDccsRpEaLTGFHKRKhpRpKcAQE.hcc+tR.t+hEERK+lR-ER+pchpctlcphccthp.lpcttsstcctpsspsppspt-...................s.t.......p.sspspptp.hDpcph...................................osVslEpl-s	.................t......pt..thtplsFDccsRpEYLTGFHKRKhpR+.....Kp..Ap-phcc+h+.tphEcR++lR-ER+pp...h.p..c.....hl..p.....p.h...c..ct..h..p....hp...p...t....tsp.pp.......pttpp...p.p.p...............................................p...t.s.s.p.p..-.sth...........................................................................................................................................................	0	67	110	164
+9638	PF09806	CDK2AP		Cyclin-dependent kinase 2-associated protein	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4713)	Family	Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.	25.00	25.00	25.00	26.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.36	0.71	-4.07	11	192	2009-01-15 18:05:59	2007-07-30 14:31:31	4	4	91	2	111	168	0	120.90	43	82.32	CHANGED	MsYhsItss.Sphs.................ssTshPtssht..............................................................................suGSssosS.........................................................................................................................................ss.suuuhhpPlhSshs.PShG...ssssh.......oKYupLLuVIEEMG+-IRPTYuGS+SuhERLKRGIlHARhLVREC...LtETERsARp	................................................................................................................................................................................s.s......................................................................................................................................................................................................................................................................................................................s...ssu.s.h...p.lh....s..c.h.us...PShG.h.sp......sstss.........SKYu-LLulIEEhGK-IRPTYAGS..K..SAhERLKRGIlHARsLVREC...LtETERsAR..................	0	25	34	69
+9639	PF09807	DUF2348		Uncharacterized conserved protein (DUF2348)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4723)	Family	Members of this family of putative uncharacterized proteins have no known function.	31.60	31.60	31.70	31.70	31.50	31.50	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.66	0.70	-5.27	5	176	2009-01-15 18:05:59	2007-07-30 14:31:58	4	4	121	0	114	164	0	204.20	28	87.66	CHANGED	MFPELNsLLssoPDpsE........pGKlTLLCDu.KTDGSFLVHHFLSFYL+..AuCKVCFVALVQSFSHYSIVGQKLGVSLTsAR-+GQLVFLEGLKSul-llFp...su-sspPLpFLREussGsLcsLFcFVp-oL+..PusSuGs.WphPVLlVDDLSVLLS..LGVuAlAVLDFhHYCRATVCoELpGNlVlLVH-sE-AuDE-s-...lLLpGLSHQSHLIL+AEGLATGFC+DVHGQLcILWRpsSsSutpRuQoh..sYQYKIQD	............................................................................................................................up.hhll.p-t..pssuuFllpphLp.hL+............us..s...t.......lhhluh.p.shsHYp.lup+...l....G.hsLshtpc.psplsFl.-sLp.....ht..........h....ht...............t...t.ttsp.........t.hh.....ts.s.........s....t.L...p.La.p..lpptlp.....s.s.s.t.ts.............sslllDDlSlLhs.........hG..h.u...s.h.t....Vl....c...Fh....chsp.sls..h.p.....h..p.s..s..hV..........hLs+......ts.....tp.s.......p.cpst.............lhptLta.uplhlpspsLsTGhspDVcG.plpl.....c..........................................................................................	0	38	55	87
+9640	PF09808	SNAPc_SNAP43		Small nuclear RNA activating complex (SNAPc), subunit SNAP43	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4746)	Family	Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.	25.00	25.00	25.40	25.00	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.25	0.71	-4.63	17	185	2009-01-15 18:05:59	2007-07-30 14:32:26	4	4	132	0	126	174	0	174.70	25	47.41	CHANGED	sl+pDhcpLLpcFtpt....coscFpsFpplWcchp...FpplFpG+ppssEhhtFsptlLhhshtYhhss.........pohppRluuLYhLYslY.pQ.sp.hhKIRlshpsapchpcaspphh....ppphh.-sshlhp+LhpcpAF+FsAh.phhs.shh+ph....p...hptpstpphhsstspspplhp.ph.....lpcLt.lcttYpchK	........................................hppDhctLlpc...Ftph...........pshpFpsFpclWcphp...Ft.tlapu.p...pph-..h..t.pFscphLthsh.p...ah.hss...................................................hohp.RluuLYhLYsLYpsQ........s....ps......h...............hKI+lslcsapplh....ch.pp.hh.......ptphh.-sshlhp+.L.h.p.pAFha...s...Ahs.phhs...t....h.pph.........p.....hh.th.....tph.th.p...t......hpth..hpttYtphp.............................................................	0	43	63	101
+9641	PF09809	MRP-L27	MRP_L27; 	Mitochondrial ribosomal protein L27	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4756)	Family	Members of this family of proteins are components of the mitochondrial ribosome large subunit. They are also involved in apoptosis and cell cycle regulation.	25.00	25.00	25.50	26.30	24.50	24.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.22	0.71	-4.46	16	274	2009-09-11 08:35:56	2007-07-30 14:33:14	4	3	242	0	196	253	1	95.10	31	65.91	CHANGED	+sus++hshToKpGs+sa..hKG.............+GupshGhhspsG+alh.h-hV.palVPs.LpshcLKPYVSapsPplpps................hcsacpGhhcs-hh.chshE.spcG+l	......................................................................................thh.LToKpus+sa..YKG....................psspshGha.s..p.pGpYllshcKl.saVVP-....Ls...sF...+......LKPaVShpssthhpp............................................................................................	0	59	103	160
+9642	PF09810	Exo5	Morph_protein1;	Exonuclease V - a 5' deoxyribonuclease	KOGs, Finn RD, Sammut SJ, Coggill P	anon	KOGs (KOG4760)	Family	Exonuclease V is a monomeric 5' deoxyribonuclease that is localised in the nucleus. It degrades single-stranded, but not double-stranded, DNA from the 5'-end, and the products are dinucleotides, except the 3'-terminal tri- and tetranucleotides, which are not degraded. The initial hydrolytic cut of exonuclease V on the dephosphorylated substrate produces a mixture of dinucleoside monophosphates and trinucleoside diphosphates. The enzyme is processive in action [1]. Exo5 is specific for single-stranded DNA and does not hydrolyze RNA. However, Exo5 has the capacity to slide across 5' double-stranded DNA or 5' RNA sequences and resume cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively [3].	25.00	25.00	25.90	25.30	23.90	24.60	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.10	0.70	-5.20	13	244	2012-10-11 20:44:46	2007-07-30 14:33:33	4	5	193	0	168	260	3	317.10	25	67.42	CHANGED	SPlcRF+p..ppslSVTDLsustWCElQhhYsLsc..hG+KccTtAM+pGsplHcpLEcElassVsVc.....V...TT+EDshuL+lhNhIptLppLpppG.............hsREl.VaGhl.cGpllsGlIDpLshcssc.phppp......p..h..........................................................clhloDsKTRtusolPo..psQhRsohlQL.LYp+hLschss...................................splshpplhscY.......sLDPpcsFossahsp.u.ht.......................................................p..t..hhcapsLpsLhphhhtphphp.LP...........................hlssphphcYcppsssp.....lluscpaha-.cslcthls-thsaW+GpR-scGV.cspEuWKCRhC-Ft-pCsWp	...............................................................................................................th.......phLsVTcL.hs.tWCEhph.Ysh.t..................hh.p....ts.s.........hctGpphHttLEp....Ela.p...ltl...............................l...poc.....E...Dshu..l+...h............h.Nhl.tl.pLhp.pG..................................................hsR..Eh.l..........a..G..hl.....c.................s..................hlsGlIDpL......p...h..p...s..p................................................................................................................................................................plhlsDhKT...R....t..p.........plPs...ps.t.h.c.s.splQl.hY+.hhhsph.sp................................................................tp.hsht.thh...pph.........tLs.sptshs..t..hht.p...............................................................................................................................................................................................................................................................hh.pht....s.L.tp.lhthh...t..hph..hs....................................................................................ht..hthpY..pts...................hspp.h.as.p.lpthlpp.htaWhGpRpspsV.........p-t...h...K...CphCca.tp.C.h...................................................................................................................................................................................	0	50	92	134
+9643	PF09811	Yae1_N		Essential protein Yae1, N terminal	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4774)	Family	Members of this family are found in the N terminal region of the essential protein Yae1. Their exact function has not, as yet, been determined. The family DUF1715, Pfam:PF08215 has now been merged into this family.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-7.90	0.72	-4.42	82	669	2012-10-02 21:03:42	2007-07-30 14:34:13	4	24	410	0	356	588	16	38.90	34	17.48	CHANGED	GYp-GhspGpppshpcGhp.Gapp.Ghp..hGhphGphtGhh	.........GYp-GlspGpppuhp....cGhptGhpp.Ghp..hGhphGthpGh...............	0	93	179	275
+9644	PF09812	MRP-L28	MRP_L28; 	Mitochondrial ribosomal protein L28	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4778)	Family	Members of this family are components of the mitochondrial large ribosomal subunit.  Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S) [1][2].	24.10	24.10	24.20	24.50	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.82	0.71	-4.40	14	225	2009-01-15 18:05:59	2007-07-30 14:34:48	4	4	207	0	158	213	0	134.30	24	72.35	CHANGED	hpApPh+KKKKlDP....pppttt+c+lc+plR.+hpKssppLpPl--hhss.p.lcpsppRp.thhclo.E-l-+Rsll.KpWupY+ppp+pt-hphlcphltuQpcALppLch.Ss-LYptAlts-su.hhPhchcsPstoPP............p.o+la	......................................................................................................l+...php.+.t.t....ph........Phtp.h.hs.....h.p...+p.t..lclut..-ch.++thlp+sWslapppp+ctcppplcp.hpu.pcAh-EL+.......t....S...............cLaptA.................t......-.........t...hhPh.p.h.phP...hPP......................................................................	0	48	74	125
+9645	PF09813	Coiled-coil_56		Coiled-coil domain-containing protein 56	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4782)	Family	Members of this family of proteins have no known function.	21.10	21.10	21.10	21.10	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.07	0.72	-4.02	4	119	2009-01-15 18:05:59	2007-07-30 14:35:03	4	6	108	0	85	117	1	85.20	31	62.89	CHANGED	MAt.......osKEGsA.aApRIDPo+EpLoPtQlcFMRplEhtQWpK..pht+hRsRNllTGLuIGulVLGIYGYTFYSVuQE+FLDEhE--AKAARt.uh.hppss	.................................tt...h.............................................t.hp...php+........th.t.h.R..t+NhlTGLuluu.lVluIY.......uYThhuVpQEcFhD.....-.h..-c.hph............st.....................	0	21	38	62
+9646	PF09814	HECT_2	DUF2351;	HECT-like Ubiquitin-conjugating enzyme (E2)-binding	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4784)	Family	HECT_2 is a family of UbcH10-binding proteins.	19.00	19.00	19.10	19.20	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.32	0.70	-5.73	28	316	2012-10-03 14:42:41	2007-07-30 14:35:36	4	9	236	0	227	300	2	298.30	16	76.93	CHANGED	Ehhsplpshplhlphsspht........sls.sphplplsps....................shplpLPsclphsspshhththtst.............slphclplpptsss....................thsspslpsps........hplhCpsCppsllps........pshp................+lh-hPSEtWsphhD.WaCHpss.tstptt..............................ppLpPpps-.lhlGssahL..lppsphpphhhhtt...................t.lhCppCps.LG..........phsspsh+LaKhslph................t.ss..cph..pphlhtpllphlpspusc.............+Fhlpt..........sspphl.....hlWlhssshtlsp....stt...........................................tsspsuhKlLYp.......t..thhshhpss.slcplplP...stshpphhphLppsNshlPtshR..thss........aplu	.........................................................................................................................................................................................h...............................h.h....h...............................hthth.h.t.........................................h.tpphpstp..............phhCppCtp.l..lpp........pph......................phhsLPStpW...tth..h.-.W....t.......CH.ss.tp..........................................ptlhs.ptsp.hh....lu.shhl..hp..pssh.p.t....................................................................................lhC.....t.pCt..lG..................................tt...tshcha.hhtl.h............................pp........pthhst.llph.ptpssh.................+hhlps....................ttp..l........h.lWlhssp.h.hh........s..........................................................................................................................t..tuhKlhYp........................t...............tht.....l..h.......h.thh..lttsp...hP.t.p.........................................................................................................................................	0	65	116	185
+9647	PF09815	XK-related		XK-related protein	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4790)	Family	Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems [1][2].	20.20	20.20	20.40	20.30	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.30	0.70	-5.44	35	705	2009-01-15 18:05:59	2007-07-30 14:36:05	4	12	97	0	433	583	1	269.20	23	65.58	CHANGED	c...hhhslhulhhahsDhusDlaluspYatpucahatuLsLsFlllsSlllQhhSahWappDhspsphp...............................................................................h.hhsllHlLQlGhhhRahcslphuhpsthpppppp............................hpthhhtpsDl...oMLRLlEoFLEosPQLlLQLaIhl...............................tp....ps..phhQhluhshShhSluWullsYp+s......LRtphsDKpphsh.husllhhlW+lhhI......................suRllulsLFuulhthasshhhhhhWllhh......hWshtpp.Ts.Ftp.ohshEhlaphlVGllhlFsaFN................VccupTRtRhhlYYshhll-slllhhl.h.....hhh+sshhsp.htlhlsssl....hssahlGlhhhllYYphhHPs	............................................................hhsh...h.p...thhh......ah..tt..p........h.h.hhsh.h...h...hhsshhhp...h.s.h..........ah...h...s.t..t.t.............................................................................................h.hph..h....h.u...h..h.........R......h..hpshhhhh......p..........ttt...............................hhhh..hp...ssh...shhplhpsaL.tos.PQLhLQlhlhl....................................................tp......tth.......hthh.hh.hShh.ulsashhthphh..............lp......hs...s....h........h...sh...huhl...h.hh.W+hh...l......................ssRhlsh.sLF.sshh....hhhhhh.hhhpahhhh................hWh..hhtt...sp....ht..............s...........h..................t.................hhh..h.lh.uhlhl.ash.hN.................................l.pcs.p.st..h+hhhaYh..............hhhhENhhhhhh.a..................h..h.t........................h.............................hhh.l....h.sahh.u.l.....hhhllaYt...hhHP..............................................	0	122	154	274
+9648	PF09816	EAF		RNA polymerase II transcription elongation factor	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4795)	Domain	Members of this family act as transcriptional transactivators of ELL and ELL2 elongation activities [1][2][3][4]. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. The N-terminus of approx 120 residues is globular and highly conserved [5].	20.20	20.20	21.40	20.70	19.40	17.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.68	0.72	-4.09	29	307	2009-01-15 18:05:59	2007-07-30 14:37:57	4	8	211	0	216	291	0	104.00	31	29.65	CHANGED	pYslhLGsphp.............scssps.....phhsl+YsFKPsSssssp..splpts.....pspphslsl................sssuspss..hsacGs..........spss..pppchlLlF...........DscspsahLE+lsosl.phphpRsss	....................aslpLGpohp........................cpsps.........tFpolRY..-FKPAS.lDsopt...uplpsu.........pssplslol.................phpuus..ss..slFcGs.......................p+sh..p...c-slLlh...........stc..otthhLE+Lsosl.pl++sRs..s.......................	0	60	99	156
+9649	PF09817	DUF2352		Uncharacterized conserved protein (DUF2352)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4803)	Family	Members of this family of uncharacterised proteins have no known function.	25.00	25.00	25.40	25.30	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.95	0.70	-6.34	9	120	2009-01-15 18:05:59	2007-07-30 14:38:32	4	4	80	2	74	113	0	412.90	28	87.48	CHANGED	PspYhsslpst............h..tsp....schlalhc............................pspL-hpssshc-sh.pp.suls-........LSlcp.ht....................tslslt+ARpllshhpht+s..shu............slWlhCDGSD.ptTshLthEhst....psphhpGllhahssps......sh.hohpsLtppHpp+tt.uh.pspthuh.pha..........pspsplTlcloWssssp.....hLppsslu.stTlplc.t.h-ppuss.pphappLcFLlslt-slhohcsEhhpshpscus..ss.sph.ls-Lcpclsphhssssc.pspphspssst...tsh.phlpsRtshDhs-pLWshh+p.ssSYpDLptsFshlhQshp+usIts..pssssopLucLIpp.hpschshssLoGspPhchLLEIGL-KlhKDYhshFsppclsohNhLchhh..............................................................sophDtpEpshRlpKLaplhplL...pphLhlchphclh.haopsC.cYh+csPhs.pcla.......pl.lpsphlpchhpsccPhph+VphsSspt....+cVcTsa.hsscs.ls......schs.phpssspp.....ccthahhphlpspp	............................................................................................................................................................................................................t...................................slsh.pu+tl..ht....hhtps..shs.............slWhhCDuoD...tt.ThhLthph........sp.h..pGl.hhh.ssh.........t...p.p.tlhp.....a.tth..s..t..th...phh.................s.sth.lchpWts.st..................hp.ss.......tthhplt.......-.ps.h..thhppL....phLhhl...tcslh.shhp-h....sh....pt.psh........ht....t..hs.cL.pphp...t..........h.sphpt...t....h..tp.........th....h......Rt.hDhs-pLWphhpp..s.oap-lh......sh.phlhpshtpup.lts.hp.s.spshLuplIpp............hpt.pht..............s.LsGh.......PlphLlElGl-Klh+DYh.h.......ah.t.pchsshs..Lp.h......................................................................................ssth..s.pcth.+l...t+Ltplhthl...pph...hhp.thph....hs.p.s..phhpp..h..p.h...............pl.l.......th.l.....pp..h.hptppP..h.phph.st.........ppl.T.sh.hs.p..h.............t................................................................................................................................................................................	0	21	27	51
+9650	PF09818	ABC_ATPase		Predicted ATPase of the ABC class	COGs, Finn RD, Sammut SJ	anon	COGs (COG3044)	Family	Members of this family include various bacterial predicted ABC class ATPases.	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.29	0.70	-5.90	44	462	2012-10-05 12:31:09	2007-07-30 14:40:15	4	4	429	0	135	1778	323	421.10	45	75.58	CHANGED	hppLpphLpplDs+sYtAYKplpGp.Ypas.....p...apLhlD+VQuDPFAsPScl+ltlstshs..................shstthh..psts+plAhpDals...Rphtpth...........thtssscoGhltlspsGQplLcRoushl...........................ssptl...clRhpVuLP....ApGRcIhu+tAhplLhptLPcllccslhhpth......stcplppalphscDQptLRppLtc.......tGLVAFVAsGuILPRcSGsS-+......Phc..sAVPFpSPc....oLc.lplpLPp.tGplpGMGIPcG.lTLIVGGGaHGKSTLLcALEpGVYsHlPGDGREaVlTcssAlKIRAEDGRslpsVDISsFIssLP..tGcDTs.pFoTpsASGSTSQAAslhEAlEsG..............upsLLIDEDTSATNFMlRDtRMQpLls+ccEPITPFl-+l+pLhcchGlSTllVs.GGSGsYhclADpVIhM-sYpstDlTtc.......A+clspp....hsstpttpstt.........sR	...............................................................................................................................h.ppLhphLppl-tpsYtAY+plcGp.....YcFs...................s........apLhIDHlQuDPaAsP.S+l+shhshphs.................................................sh....s......hh.....ps.ht.phA.hpDals...RtFtphh..........................t.....t........psutlpIstsGQplL-..RTulhh........................................spctl.........ElRhcluLP...............ApGR...sIh.u+pAtplLhptLPchlccuhhhc.pl.............stptLhppsclsEDQchlRppLpc.........................tsLVAFVAsGulLPRpoGssDh......Phc......sAVsFpo..Pc.......oLc..lshphPs....t........Gpl..p..G...M..G..I..Pc....G.ITLIVGGGaHGKSTLLpAL...Ep...GV...Ys...H....IsGDGREaVlTcssAhKIRAED.G..Rs.l.p.s.l.sI...SsFIspLP........hG.+.......DTs..pFS.T.p....s.A...SGSTSQA..AslhEu.lEuG......................................ussLLIDEDTSA.....T...N....F....MIRD...tRMQtLlu.+..pc..E...PI....TPhl..-RlppLh..cch....Gl.S.T.llVh..GGSGDYhD.V..A..DsVI..Mcs..YpshDV.TpcA+clstp.hsp.ct.t...................................................................................	2	67	107	127
+9651	PF09819	ABC_cobalt		ABC-type cobalt transport system, permease component	COGs, Finn RD, Sammut SJ	anon	COGs (COG4721)	Family	Members of this family of prokaryotic proteins include various hypothetical proteins as well as ABC-type cobalt transport systems.	20.80	20.80	21.30	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.69	0.71	-4.19	51	1105	2009-01-15 18:05:59	2007-07-30 14:41:44	4	2	991	0	157	535	10	127.90	35	65.84	CHANGED	lhDIllsulluVshGlla.hsashlhsslsshhs...hsPhhpsl.................hhGlWhhuusluuhllRKPGAAlluEhlAAhlEhllGupaGst.slltGllQGLGuElsFA..lhtY++ashhshhLuuhsuulsshlh-	...........................................pDlllhuhlulhFGlla.hshshl.Y.shlpshht...htshhppl..................hhGlW...h.MAAslAulll.KPGuAlluEllAAhs.Esl.h..G..u..paG.ls.slluGll.QGLusElsFh..lh+Y.+.phshhshhluuhssslsuFsh...........	0	45	96	131
+9652	PF09820	AAA-ATPase_like		Predicted AAA-ATPase	Mistry J	anon	Pfam-B_5377 (release 16.0)	Family	This family contains many hypothetical bacterial proteins.  This family was previously the N-terminal part of the Pfam DUF1703 (Pfam:PF08011) family before it was split into two.  This region is predicted to be an AAA-ATPase domain [1].	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.03	0.70	-5.24	84	1607	2012-10-05 12:31:09	2007-07-30 14:44:05	4	10	265	0	256	1536	96	241.50	31	54.30	CHANGED	PIGIQsFcclRpcs...YhYVDKTthIhpLhpsusha.FLSRPRRFGKSLhlSTLcsaFp.....Gp+cLFpGLhIcc.pp.........tW....tpYPVl+lshsstph.pohppLpptlpphlpphtptashthp.............................cpshssphttlIcphhcppGppVVlLIDEYD+PlLpslp.st......p...........hhcchRp...hL+sFYuslKs....t-saL+FshLTGVoKFupsulFSsLNNLpsIohsp..pYsslCGhT-pElcphhp..hpths.....shcthhpcl+chYDGYpFs..s.....slYNPFslL.hhpp	.......................................PlGlpsFpcl..h...pps.ahYlDKTt...h...l.........p....l...........h....p....p...s..p....h...hhoRPRRFG.K.oLhhoh...Lc...taFp...............................tpccLF.p....s....Lh..I.tp.....p..........................h......s......pY..PVlh...ls.hp..shph..tsh...p..p....h.p.lpth.lp.th.p..ath.hp.........................................ptshttphttlhphh.hpp.h.s.pplllLlDEYDpPh.ps.ht.pt................................hhpphhp..........hh+.s.h.a.sshhp......tsthlc..hshlTGl.+h...s..p........ulF......Ss.......LNp.h..p.s..h....o....h.s..pa..s.p.hhGhTcpElcphhp...................thpt...hppl+phYDGY....pFs..........tlYNPasll.hhp.p.....................................................................	0	142	228	252
+9653	PF09821	AAA_assoc_C	ABC_transp; AAA_36;	C-terminal AAA-associated domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4754)	Domain	This had been thought to be an ATPase domain of ABC-transporter proteins. However, only one member has any trans-membrane regions. It is associated with an upstream ATP-binding cassette family, Pfam:PF00005.	21.30	21.30	21.30	21.40	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.28	0.71	-10.04	0.71	-3.84	49	413	2009-01-15 18:05:59	2007-07-30 14:44:22	4	2	357	0	152	349	21	118.50	38	29.96	CHANGED	spLAcclpl-lD-LhPlsEuhplLshAclpsGDlpLTstG+pascuslpcRKclFsppLhphlPLsspI+phLcccsscphscpphhctLccahssptAccsLcsllsWGRYAElatY.D-	...............PcLAcpLpl-lDDLaPlsEsLphLtFAcl..c.c..G..DlhLTshGcpFs.cus.h.pERKtlFucpL..lchVPLsspI+c.lLc-.+..s..s+pssppRFtpcL..E-...a..h....o..pptAccsLcslIsWGRYuElFsYD...........................................	0	38	81	117
+9654	PF09822	ABC_transp_aux		ABC-type uncharacterized transport system	COGs, Finn RD, Sammut SJ	anon	COGs (COG3225)	Family	This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.62	0.70	-4.94	88	807	2009-09-11 15:43:23	2007-07-30 14:46:11	4	13	632	0	316	818	488	225.20	19	41.63	CHANGED	RhDlTpsphYoLSpsocplLppLcp..Plplphahss................hpphtsplcclLccYpthus.c...lplcalD..P........................ptssttpc...t.Gh.s.....................phasslll...phsscpphlshhs...................t.tthEhplopul...pclsps.....p................................................................................................................................................ptplshlsGpuEh.............................................................................................................................................sttthsphhppLppp..a..plpslsLs.................tspl..PpcsclLllssPpp.ls-pphhtlcpalh.pGGcllhhl-sh.t.............s......................t.sLss...LlppaGlplssshVhD	.....................................................................................................................................................................................................................................................................................hDhotpphaolo.to.phlp..p.lpp...............sltlhhh...hp..........t............................h.tth.pph..l..ppat....t...h...st..p....lphphhs.....s................................t....tp..............................................................................hhh.....t.t....t.p.thl.h.t.........................................Ehpls..psl....plhpt.......t.....................................................................................................................................................p.hl.hh.hpupsph...................................................................................................................................................tt..th......t......ph......tptLp......pp..a...pl.....p..p..lslt....................tppl...psss....l.lllssPpp.hsp.....pEhptlcpalt.pG...G....p....l....lhhhssh..t...........p....................................sls..ll.ppa.Glph.psshlh.........................................................	0	156	231	275
+9655	PF09823	DUF2357		Domain of unknown function (DUF2357)	Waterfield DI, Finn RD	anon	COG1700	Domain	This entry was previously the N terminal portion of DUF524 (Pfam:PF04411) before it was split into two.  This domain has no known function.  It is predicted to adopt an all beta secondary structure pattern followed by mainly alpha-helical structures [1].	20.60	20.60	20.60	20.60	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.57	0.70	-5.28	22	202	2009-01-15 18:05:59	2007-07-30 14:48:20	4	5	189	0	66	203	17	224.80	20	32.58	CHANGED	tGplsFsNclGhsphtlt.ttp....thhplphEVhssKls....app-actlLpp.....lscphsplhhphhppT.hphpts.ptstss.h.hashlcp......hhpsL.pulctIhppPHppL.pppphh+ssplpchssthhttltcpst.......................hstphhspphhptcpchohDT.ENRFlKahLpphppclt...plpptltptttphttt.....hhpplpphtcplpchLppsha+cVGphpthsspShVLpptsGY+-la+ha	..................................................hph.s.hG..ph.hh.ttt.....t.hphth-VhstKhs.....................hpp-apthlp-.....ls.p.h.tlhhphhpt.o.h.t...ht......t.t...tss....hh....thlpp........hpphhpulppIhppP+ppLhpcpphhpsccl+chsstshp....ltccsthh......................tpphh.spphhssp..+..phohDThENR....FlKahlp.p.lhcplp...........pl.hp.tl...pt...t.pp...t...........................hhppl.ppht.phpphhp.p.shhptlup.hp.t.s...S.llp.t.GYpphapha.......................................................................................	0	30	48	59
+9656	PF09824	ArsR		ArsR transcriptional regulator	COGs, Finn RD, Sammut SJ	anon	COGs (COG4860)	Family	Members of this family of archaeal proteins are conserved transcriptional regulators belonging to the ArsR family.	23.90	23.90	23.90	150.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.84	0.71	-4.91	12	29	2009-01-15 18:05:59	2007-07-30 14:48:53	4	1	28	0	26	33	9	160.40	40	94.30	CHANGED	lNDPu-LVPLhpsFsScs++KlaptLsstWhTct-l--hhGp-s..pcuLplL+KusLlEoQWRhP.csGppPpKEYHosYS+VQsNF.sShpDLuDlIhlsFhs.--lc-hh-clcphlcp.GssSlusloRsLshsPhaI+ulA+RSptLsV+GQ+lcllc-	lNDPu-LVPLLpsFsScsaK+Va-tLoppWhTcpELc-hh.Gc-s..pcuLplLKKuuLlEopWRMP.cPGppPpKEYHooYo+lpANFQCohcDLu-lIhlshhsDE-l+-hh-clcctlcs..GNsSlssLoRphslSPhaI+ulAKRSppLsVKGQ+lclsc...	0	7	21	23
+9657	PF09825	BPL_N		Biotin-protein ligase, N terminal	COGs, Finn RD, Sammut SJ	anon	COGs (COG4285)	Family	The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase catalytic domain.	24.90	24.90	24.90	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.17	0.70	-5.67	13	349	2012-10-03 00:28:14	2007-07-30 14:49:48	4	13	294	0	194	322	23	253.10	28	58.70	CHANGED	MNVLVYsGsGoTspSV+HslpoLRhLLtPaYAVssVsspsLtpEPW.spsALLVFPGGADLPYCcsLsus..ss++IpcaVpp.GGsYLGFCAGGYaGSuRsEF-lGDPshEVsGsRELuFFPGssRGsAFpGFpYsSEsGARAspLplsp........tssspFpsYYNGGuVFl-A-Ka....sNVElLAcYsEcs-lsssps...........pAAlVas+VG+GpslLTGsHPEFssp.Lpptsst......thptll-pLctp-psRhpFh+tlLpKLGLc.............lspsss.sssPsL.......Tslalsupss.......splpchhssl..p-.sspsssp....hlcsp..sDpFphtcstp....................................................s..sut.......pssphtD.ccssKpllh..pspslPspchoPpFDhctYassL	.......................................................................................................lhlYss.G.ss.......sl...c...psl.tL.+....th.ht...s...p..h...t...V.....l...ss.p...l.h..pps.W..t.p.ss.LL.VhP.......G.Gs.D.l..s.Y.s.psLs...st...................GsppIc.paVpp.GGsaL.GhCAGuYaustt.....hpFt.s.....s....thtl...upRp.LthasG...hstG..sh...h..t.s..a.Yp..op...tGs.p...s....s..l.htt.............t.h..aa.N.GGshF..ss.ph......thpllApYtp.................................sAhl.pp.......h.G.....c..GtslLoGsH.Eh..................s....t........hp....................................................h..hh..........................................................................................................................................................................................................................................................................................................................................................................................	0	71	117	161
+9658	PF09826	Beta_propel		Beta propeller domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4880)	Family	Members of this family comprise secreted bacterial proteins containing C-terminal beta-propeller domain distantly related to WD-40 repeats.	22.40	22.40	22.40	23.20	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.78	0.70	-6.16	28	199	2012-10-05 17:30:43	2007-07-30 14:50:25	4	9	169	0	97	204	204	474.40	25	72.41	CHANGED	cYSsTNlQVtGVDEuDlVKTDGphIahh.s.s..............splhllcuhP.......s.pph+llup..lshsup....pcLaL..psc....pLllls.....st.t........ss...................s..h.tshspshlYDISD.ppPclltplplsGsYlsuRhlsutlYlVssphsphh..................................h.t.p.pshhPthhss............hhhsss.hahPs.sthssa...s..slsulsl..sssp.sssssllG.su.splYsSpssLYluhsphh...h...........................................................................pt.ttpppTtla+Fslss...sclpahusGpVsGpl...LNQFShDEap.GhLRVATThsp........................................................hptpstspNslalL....D.psLchlGclpsLA........GEcIYSsRFhGDpuYlVTF+plDPLFVlDLS-PppPclLGELKIPGaSsYLHPls-s+LlGlGp-sspp.............s..p.GlKlSLFDVoDsssPpEhsphhltppsspSssht-H+AFhacpp+...sllulPls.....................h.hpshhlacls....ssGhshhuplsptsss...................lhRulYlsD.....hLYTlSpstl+shshsshc	..................................................aSpTNsQhtGVDEuDl..VK.o..DGphlahhs..t......................................pplhlhcs.s........................pphphhuplphttt.....................plal....pss.................pLllls.....pt...............................................t.sthhhaDlu.....s.t...p...Pphhtphphp.Gp.h.....hs..uRhhs.shlYllspp...h.......................................................t...t.hhP.http....................hh...tp.hhh........st.......t..sh.........h..hlsuhsl.........pssp...hs.t...sh..hG...ss..stlYhStp.slYlstpth..........................................................................................ttttTtlh+hslps....sphphhupspVsGhl.....hspFuhDEas....GhhRlsTTht.............................................................t.ttpspNslalL........D..pshphhGpl..p.slu........s.Ep.IYusRFhGcpuYhVTF+...psDPLFslDLpsPppPpllGtLK..IPGaSsYLHPh...s-s+llGlGh-stt...................h...GlKlulFDVoDsss..Ppp.htphhl......t...p...ss.S..pshhs..a+..Ahhh...st..pc............slhshPhs..............................hpshhl...apls......ppG.hphhtplph.s.............................................h.Rslals-.....hlYslotthlps.shts.........................................................................................................................................	0	56	76	86
+9659	PF09827	CRISPR_Cas2		CRISPR associated protein Cas2	COGs, Finn RD, Sammut SJ	anon	COGs (COG3512)	Family	Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	21.10	21.10	21.20	21.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.64	0.72	-3.84	233	1845	2009-01-15 18:05:59	2007-07-30 14:51:40	4	3	1369	9	558	1538	61	82.80	23	82.31	CHANGED	M................................hhllsYDl.....ssc.......+ths+ltKhhcpaG.pplQhSVF-s.plspspht.plppclpchls...pp...Ds...lphatls...ppp..hpphthh	...........................M.......hhllsYDl.............spp............+thp+ltKhltpa.G..th..lQ..h..SVaps...pls.sspht..plhp..c.lp..ph..ls......tp....Ds...lphhpls..ppp.htp....hh...................	1	248	404	499
+9660	PF09828	Chrome_Resist		Chromate resistance exported protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4275)	Family	Members of this family of bacterial proteins, are involved in the reduction of chromate accumulation and are essential for chromate resistance.	25.00	25.00	31.90	31.90	20.60	19.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.61	0.71	-3.97	46	307	2009-01-15 18:05:59	2007-07-30 14:52:12	4	5	224	0	121	292	27	131.70	46	51.68	CHANGED	WsTRpRP+lDRlACsWLIRRFIDspAcFlaVsssp....us.hsAlsFDhcG..staoHh....G-pCoF-shlccFuL.ssPuLt+LAtlV+uADsu.phshsPEAuGL.Al.hGLSppht.DDpphLpsuhslaDALYtahc	..........WsTRpRPtlDRlACsWLIRRFIDspAcFLalsssp....ss.......tsAlsFDhcG..stao.Hh....G-tsoF-shlppFuL..psPALh+LAtlV+u.....h..Dsu...hshsP.EAuGl...Al.hGLpct.hp.DDpphLct.uhslaDuLYsah....................	0	33	66	87
+9661	PF09829	DUF2057		Uncharacterized protein conserved in bacteria (DUF2057)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3110)	Family	This domain, found in various prokaryotic proteins, has no known function.	21.80	21.80	22.60	22.30	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.04	0.71	-4.63	79	1101	2009-01-15 18:05:59	2007-07-30 14:53:04	4	3	811	0	143	559	26	179.40	33	83.49	CHANGED	ssLslsps....lclLsls...t.phpsshhpppps....lsLssG.ppQllhRapshh.......p.psssp.phhpSsshll.sFssss.pslpLphPc.hpshppAcp.Ftc.sPphpLts.ssupslshpp-hL.htsGhphspshtpplspYNt.sussAuh.......................ssssssssssssssssss.............................ttspstphLpaWappAspps+cpFhpW	......................................h.TLclsss....l-LLsls...GpK...l...u...uuL..h....cuscs....lcLcsG..aQlVFRhpchl.......hsss-c..plahSsPlll.oF.ss.p...pplshphPc.lcs...t+.-Ap+..F..st.sPplpLlD.ssupsls.lchD...hL.thsu..h..th..s.hsa-h.-...spcYNp.uuttAul..........................................sthAs.hh.ss.s.sslhssss...............................shsstupshsEppLcaWaphADspTRppFhpW......................................	0	20	49	97
+9662	PF09830	ATP_transf		ATP adenylyltransferase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4360)	Family	Members of this family of proteins catabolise Ap4N nucleotides (where N is A,C,G or U). Additionally they catalise the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulphate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP [1].	19.40	19.40	20.30	23.30	19.30	17.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.82	0.72	-4.17	64	315	2009-01-15 18:05:59	2007-07-30 14:53:45	4	8	241	0	200	306	96	64.90	31	19.94	CHANGED	sYNLlhTccahhllPRsppph...............tslulNuhGauGhlLl+sppphphlcctssh.....plLppluhs	..sYNllhTccahhllPRpppph....................tslu.lNuhGa.uGhlLV+scpphc.hlpcts.sh......plLpplGh.........................	0	47	111	171
+9663	PF09831	DUF2058		Uncharacterized protein conserved in bacteria (DUF2058)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3122)	Family	This domain, found in various prokaryotic proteins, has no known function.	25.00	25.00	25.50	25.40	21.30	22.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.97	0.71	-4.38	44	851	2009-01-15 18:05:59	2007-07-30 14:54:44	4	1	801	0	133	459	78	171.30	57	94.89	CHANGED	SLQ-QLLKAGLlscKKsKcscppp..+Kpp....+pp+cs......sttssp.+ttlpcs+tpptc+D+pLNcp+ptctcpKuhtAQl+QlIcts+lsp.tpG-lsYNFsD..ssKlKclaVspphpcpLspGpLAIsph......pssYtllPctlA-KIspRDsshllhhss...pspst.....-EDDPY.....A-atIPDDLMW	..............................TLQEQLLKAGLVoSKKhuKVpRTA....KKSR..........VQA.REA...........................RtAV.EEN.KKAQLERDKQLSEQQKQAsLu.KEhKAQVKQLIEMNRIsl....upGD...I.......uFNFTD..sNlIKKIhVDKLTQsQLIsGRLAIARL......E.scYAIIPAuVADKIAQRDAsS..IVLpuA.......lStEEQ.......DEDD..PY..AD..FKVPDDLMW.................	0	25	57	98
+9664	PF09832	DUF2059		Uncharacterized protein conserved in bacteria (DUF2059)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3184)	Family	This domain, found in various prokaryotic proteins, has no known function.	23.60	23.60	23.70	24.40	23.50	22.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.77	0.72	-3.95	125	777	2009-01-15 18:05:59	2007-07-30 14:55:24	4	3	654	3	230	656	55	63.20	22	31.68	CHANGED	shschppth.hshaspph..opp-lpplhsFYpSslGp+llptpstsppp.hp.thpth....spphhspl	................t..tphppth.hchYtcta.....oppElcslhsFYpSPsGpKllpppstltpc.ht.hhpth....htth....h...............................	0	52	123	178
+9666	PF09834	DUF2061		Predicted membrane protein (DUF2061)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3205)	Family	This domain, found in various prokaryotic proteins, has no known function.	21.40	21.40	21.50	21.60	21.30	19.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.46	0.72	-3.77	64	547	2009-01-15 18:05:59	2007-07-30 14:56:55	4	5	401	0	140	400	941	52.50	45	66.49	CHANGED	hhKTloatllthslshsVuYll.....TGslhluuslAhlEshsphlsYaFHERlWp+	....hhKTloFuslHFolAFsVuYlL........TG.slhlGuhlAhlEPslNTVuaYFHEKlWp...	0	40	84	119
+9667	PF09835	DUF2062		Uncharacterized protein conserved in bacteria (DUF2062)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3216)	Family	This domain, found in various prokaryotic proteins, has no known function.	21.50	21.50	21.60	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.86	0.71	-4.61	145	963	2009-01-15 18:05:59	2007-07-30 14:57:42	4	4	883	0	327	819	535	150.40	24	77.18	CHANGED	ahR....hhthhhpc.t.hhphs.+ulAtuhAlGlFsu.hhPh..shQhllAshlAhhhRu.......Nlslulhssal.oNPlThsslah.hsYpl..GshlLutss...........................................hth..hph.pWht..............htslhhPhllGullhullsuhluYhlshhlh....+hhhp+c...........h..pp+	.................h..+..ht.hh.hc.h....hhphs.+p....lAtuhAlGlFhu..hhPh....shp..hl..l.u.hh..l.A.h.l.h...+.s.......N..lshu.l.hs.s.hl..sNP.l.Ths.sl....ah....hsYpl...Gphlhstss...........................................hth..hp..hpat.th.............p.htslhhshLlGsh...lhullh...ulluYhlsthlh....chhht+php..................................	1	115	241	287
+9668	PF09836	DUF2063		Uncharacterized protein conserved in bacteria (DUF2063)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3219)	Family	This domain, found in various prokaryotic proteins, has no known function.	22.50	22.50	24.50	23.80	21.40	19.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.72	0.72	-4.00	112	668	2009-01-15 18:05:59	2007-07-30 15:01:16	4	4	545	1	222	634	74	91.00	24	35.49	CHANGED	tphQpsFtsslhssst..ss..............hs...tssspRhslYRsthhsslhssLsssFPslppllGc-tapshuptahppps..spoPhhhchGtcFssFLp	........................................thQptFtttlhtspts..........................t.sh.sscRhslY+phhhsslhssLsssaPhhp....pllGc-t...a.ptlsc.t.alppps..spoPhhpchutcFspalt................	0	55	117	179
+9669	PF09837	DUF2064		Uncharacterized protein conserved in bacteria (DUF2064)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG3222)	Family	This family has structural similarity to proteins in the nucleotide-diphospho-sugar transferases superfamily. The similarity suggests that it is an enzyme with a sugar substrate.	25.80	25.80	26.00	26.10	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.77	0.71	-4.50	93	550	2012-10-03 05:28:31	2007-07-30 15:02:34	4	8	506	1	212	557	305	121.80	26	49.00	CHANGED	Tlt........phtpssshshhlshssstspstht.....................hhssshthh.Q.suuDLGpRhtpAhpps..........ttshp.slllIGoDsPsLssphLppAhptLppp........-h..VlGPApDGGYaLlGhp....p....hs.plFpslsWSo	...................................................................hhh.......t...hthhlhhs.sthttth.......................hhhtshp..hh.Q....tu.ssLGpRhtpAhtps.........................tshp.slllIGsDsPplssphltpAh..p..tL..ppp........................-s..V.lG..PA.p.DGGYaLlGlp.......t..hs.plF.p.s.lsWup...................	0	84	161	199
+9670	PF09838	DUF2065		Uncharacterized protein conserved in bacteria (DUF2065)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3242)	Family	This domain, found in various prokaryotic proteins, has no known function.	20.80	20.80	20.90	22.60	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.42	0.72	-4.26	86	1053	2009-01-15 18:05:59	2007-07-30 15:03:48	4	1	1049	0	199	485	964	56.60	49	87.80	CHANGED	llhAluLlLllEGlh.hlhPsth+chhtpls.phssppLRhhGLsshlhGllll.allp	.....lhlALuLVLVLEGLGPhLaPpuW.++Mlsshs.pLPDshLRRhGGuLVVAGlVlhYhlR....	0	45	106	152
+9671	PF09839	DUF2066		Uncharacterized protein conserved in bacteria (DUF2066)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3249)	Family	This domain, found in various prokaryotic proteins, has no known function.	20.70	20.70	21.10	21.00	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.21	0.70	-5.24	60	369	2009-01-15 18:05:59	2007-07-30 15:04:52	4	1	364	0	106	346	429	233.00	28	62.88	CHANGED	Ahsls.sLYpucl..sVs.upsspscstAhppALppVll+loGspp..shpssslpptlpsspphlppauYp..........p.ts........phhLpssFcspplpplLppAplPlWu.ssRPtlLlWls...-sstsRp.lls...-pss..st..htptlpptAppRGlPlhhPlhDLsDphslsssDlWGtFsssltpASpRYssDsllss+lppp.s............tt................p.hphpW.pL.......asssspppt............sspuushsthspshhssluchhuscY..A	...............................................A.phssLYpucl..sVs.spps.sscstAhtpuhppVllRsoGsp.s.....sh.pssslpptLc..pssp.al.sQauap.....p.pu.................................ptsLplpFsspplcsLLpp.At...L.PhWs.psRPslLlWll...-s..s.tspp.llh.......-pss...........hhptlpptAppRG.L...PLtl.P...l.uDh.sD.ss.ls..ss..-lhGs..sss..lppASpRYssDslLll+hpts..t..................t..........................................................................................................t.h.hcW.pL.......aspssppts..........pussussppshsthhstluchhup+..................................................................................................................................................	0	33	56	82
+9672	PF09840	DUF2067		Uncharacterized protein conserved in archaea (DUF2067)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3286)	Family	This domain, found in various archaeal proteins, has no known function.	21.90	21.90	21.90	49.10	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.98	0.71	-4.79	13	57	2009-01-15 18:05:59	2007-07-30 15:05:35	4	1	57	0	44	60	7	190.70	25	92.48	CHANGED	loh+hssc-EhccFhctLp+t.htssah.lcs+h........s+lhlpl.Gs-+.clc-shppl+pLtspl+pch...pcuhhchsLpsLhR-As..hslPs-llsDALphhGhcscl+s-..hlcTsAsh-Ell-hsccLuchYpElchhslTsp.s++llsshuastshsl--slEEhlEpGlLccsEst..IsLpcshcpsc+cL	...............lsh+htsccEh.chhcpl.p+h...sh..h..lcs+h..........splhlpl.Gpcc.clc-shppl+plhppl+sch....tcGlhpYslsslhc.ht..tslshslll-sLch.hGhpschccs..hlc..Tshsh-ElhclsccLs-lhs.Elph.shsop.s+cllsssuhh..tshss--ll-chl-tGlhcctEct.+h.Lp+shcpAhc....................	0	13	19	30
+9674	PF09842	DUF2069		Predicted membrane protein (DUF2069)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3308)	Family	This domain, found in various prokaryotes, has no known function.	22.10	22.10	22.30	24.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.08	0.72	-10.46	0.72	-4.10	61	494	2009-01-15 18:05:59	2007-07-30 15:07:36	4	2	491	0	139	400	175	107.70	35	80.19	CHANGED	phluhsuh..luLlhLhhsWphhluP............................................lpsssshl......lhhlPLLlPLhGlLcGcsYTatWusallhlYFhcGlstshssss..pthlAhlEllLssshFsushhYsR.h+spph	..........................hluhhuh..lALls...LhlhWplhluP............................................lpssushl.....hlhslPLlLPL.GlL+.spsYTatWushllhlYFhculsthassss..pph..hAhlEllLshshFhushhYsR.h+tt.................	0	25	73	107
+9675	PF09843	DUF2070		Predicted membrane protein (DUF2070)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3356)	Family	This domain of unknown function is found in various bacterial hypothetical proteins, as well as in prokaryotic polyketide synthase.	21.90	21.90	21.90	27.90	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.90	0.71	-4.80	41	170	2012-10-02 15:46:01	2007-07-30 15:08:55	4	6	154	0	87	168	17	176.50	20	30.93	CHANGED	llDs+Nphssh.......lhPpspcstth.suhcphhpthth.........pphsltsGhsps....hspptslustGlpshllcsssp+sslllhDuNNhcsslhcclpctlsph...hp.h.lhToDsHhlsshstss...h.lG.hh...sscclhpthtpssppAtpslp.sp.suhtpshhp.lpshGpc..hpplsuss	....................................................................Llch+sphtsh........lhPpspcut.hpsu.hchhhcthsht.........pphplts.Ghhp..uh..sh..hscpssls.tuhtsh.llcs...s....p+sslhhhDuNNh-stlhcclp.cthspl...........h.o.DsHhl..sh.st..Gs.h.h.hGshh......scchspshptss.....pp.utpslc.sc.huhppsh...lhshGpc..hp.l.sh..............................................	0	25	56	76
+9676	PF09844	DUF2071		Uncharacterized conserved protein (COG2071)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3361)	Family	This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.	21.00	21.00	23.90	23.30	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.39	0.70	-4.93	36	298	2012-10-01 19:21:02	2007-07-30 15:09:20	4	2	252	0	118	282	111	211.30	27	85.83	CHANGED	hsQpWp-LsFlHWsVDPpslpshlPsGhclDsa.-GpsaVulVsFhhpps+htulP.lPahpsF...sElNlRhYVhcpss...++GVhFhSL-ss+hhsVhsARshapLPYha..upMchppps..........tplpapupR+hs.........thp........phphpssst...scs..ssLspFLTtRathasptps.pshhhclcH.sWsLppAchhth.ssslhsusGhthss....sssplhaususcl	..............ptpWpclhFlHWsVsPptltshlP.su..hc.Dsa....-....G..p...s..a..lulVsFphpsh+htshP......l.Phhs.sF.....s.EsNlRhY.Vhpsss....++GVhFhul-ss+hh.sshluRhhht.l.P..Yhh..u.cMphppss......................pplpapop+chs.............shp...........phsh...p.h..s..s............hs..ps.....ss.lph...a...LTtR........a.th........asp.....tt.....s...phh.h.h.spH..W.Lptuchhth..psslhsstGh..ss.....s...shau.s.t...........................................................................................	0	56	91	115
+9677	PF09845	DUF2072		Zn-ribbon containing protein (DUF2072)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3364)	Family	This archaeal protein has no known function.	23.00	23.00	23.00	24.00	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.82	0.71	-4.22	10	88	2009-09-11 04:52:25	2007-07-30 15:09:51	4	2	57	0	64	91	8	101.50	22	83.37	CHANGED	PH+CT+CG+lFcDGu.cILpGCPsCGs+KFLYV+-cccsp...........cs..ctsl-phtc-tccEltpspp.c.p..t....t...................ct-RIESVRIluPGoYELNLspLhcs-ElVlul.p-EGoYhlDLsShhK+p	......................................................................................................pCtp.h..ptt...hhpGC..CG.phF.a..tt.............................................................................................................................................................................................................................h-ol.l.t.G.Y-lNl..lhpp.thlht..tppG.Y.lpl.......t..............................................................................	0	11	50	60
+9678	PF09846	DUF2073		Uncharacterized protein conserved in archaea (DUF2073)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3365)	Family	This archaeal protein has no known function.	20.40	20.40	20.60	62.70	17.90	19.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.28	0.72	-4.38	14	56	2009-01-15 18:05:59	2007-07-30 15:10:39	4	1	56	0	41	56	7	104.00	53	83.96	CHANGED	LpphsoMEKIRLILDsV+cGsIVlLEpGLoP-EEu+LIEhTMpEIsPDsFoGIEIEoYPtpp..ppuhhu+LhG+ppsp.+LTVIGPANplKTL+K-cshISAhlS	....hpphsSMEKIRhILDpV+-GsIVVLEcGLoP-EEu+LIEhTMsEIsPDpFsGIEI.....EoY...Pppp.....tssohLu+lhG+ppsp..+LTVIGPANQlcTL+KDcslISALlS..	0	8	32	38
+9679	PF09847	DUF2074		Predicted permease (DUF2074)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3368)	Family	This domain, found in various archaeal hypothetical proteins, has no known function.	29.60	29.60	29.60	30.50	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.78	0.70	-5.73	10	50	2009-01-15 18:05:59	2007-07-30 15:12:31	4	1	46	0	31	52	3	416.40	21	86.14	CHANGED	slplshhhpSluFhhhulhlsssuhhuc+ts....hhSshlll.FlaslasTuhssuahhou....+ll-PL+uLPlshhsplhuVhhhI-ohsuhhFll....hlushhlsshstuLLGLlWuhhulLhG.aSluhllhltFGsphsGRtohs+slh+shGhllhhh.lhulahll.h.hphl...sthlsslhphYphlaP........hhs.sIhtshhu..hlLullYh.lhhshhYhhsl++LappL...EstcspGplphchpl+scushlohlhKDaKllhR+oQsLshlLhPlahslhhlhslsp.s..hh.....hshhhlshlsllSSlhLphhhtIEssGF......phLpSLPls++chlhsKhLhhhlI.hhlshslhhlshlass.tsslYhhhllssslLsshluhhashp+l......su-slphssh.GhlssIlhhllshlslulsulhsFhLstPlu......allssuhsl....IsuLllac+	..........................................................hh.p.h.ahhhshh..h.....hh..p.........h...hh.....l.hlhsl.ahoshtshhhhst....tlhp.LhsLPlp.t.....s..hhl..u..hh..h..hl.ph.hh.hhlh....hhss...h...hhhhh.ul..Lshlhhh.htlhhh..a....slu...hhlhhhhGtth......+huhspslh+..h..hshll.hhh.l..hh...hahh....................thh....l..hh.hhaP........hsh.sl.t......hll...llYh..hhhshhahhsh+tl.h.pl.........hpuchp.hphp.h.phpsshhuhhtKDlKhlhRp....sph....lh.hllhPl.hhslh.....hhshl.....................hslhhlh.hh.shho.uhhhth....hhtlEtps..h......plLpoLPlsh+phhhuKlLlhs..ll.hhl.hh.hhIhshlash....sthhl.hhh..hlhsh.ll.sstluhhh.shpp.h.........pscslphs.h....shhshl.l.hhllts...l....hlGlsul.h.hahhshhhs................hlhshh.hl....l..h.......................................................	0	13	16	25
+9680	PF09848	DUF2075		Uncharacterized conserved protein (DUF2075)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3410)	Family	This domain, found in various prokaryotic proteins (including putative ATP/GTP binding proteins), has no known function.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.18	0.70	-5.48	63	776	2012-10-05 12:31:09	2007-07-30 15:18:44	4	21	611	0	219	3403	1226	288.50	20	51.73	CHANGED	+plhllpGssGoGKollulslhscl..............sp.............ppthstalssNps.ht.....hlpcplstsh..........tthhpphhtpssuFIpshp......................t.sphDllllDEAHRLhs...........pts.......h.phtt.tsplp-lhcp.u+..lslhlhDpsQtlphs-hsshpp.....lcchhpphshpht.................................pLssQhRs.tuucshlsWlcsllphpthtshsh.............ppsa-h+lhcsspphppt.......lcp+.....sptss..p..uRllAuasasht.....p.psshtshhl.......tp.aph........................tWshpst.....................Wspps.psl-cVGola.....TsQGhEL-YsGVIlGs-lhac......psththptp..phpDtsstpp+.................tt.htpllpNsY+VLLTRGhcGhalassD	.................................................................................hhhlpGssGoGKoll.h...h..plhtcl..............................................t..................................................................t..tt.p.s.......a.l...s.....h...N.....p..s.....h.....................h...l..h...p..p..lspph..............................h.p.p....h..h..p....s......s.....s.....h..l.pphp...................................................................................................tph.c.ll.llDEA.....p.hlhs...................................................p.t....................t.h.t....tspl.p.clh......pt....sc..............lhlh.hh.D.t...t.Q...h...l....p....pphht.t...............lpp..hhtth......h.t........................................................................................................pLppphRh.....t.......s.....t...t...h..h..p.....a...l.pt.hht...t.................................................tta...phphh...ps...tt.......h.t................l.tt............................................tt...................thh.s....s.sh...............................h........................................................................................................W.....................................ht.....phus.a.....shQGh-hsashlhhs.sh.........................t...p...................................hhhp.h.hLhpRuh.Ghhlh.........................................................................................................................................................................................................................................	1	59	123	170
+9681	PF09849	DUF2076		Uncharacterized protein conserved in bacteria (DUF2076)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3416)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	38.00	38.00	38.40	38.40	37.90	37.60	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.75	0.70	-4.32	44	304	2009-01-15 18:05:59	2007-07-30 15:19:05	4	3	286	0	119	304	5	229.80	31	98.75	CHANGED	MsspEppLI-sLFsRLppscss.........PRDspA-uhIsctlppQPsAsYhhsQslLVQEtAL+phpt+lppLcsph..............stttttt.uGGFLu.uh....FGustsp...s.Pts..ssts......................tssasptts..ts..............p.thsts............t................GuFLGsAhsTAAGVAGGslLhsulpshFssspt.tthss..t..................ssss.u..........p-sshsshtsspsts............................h-pus.st.s..shsDus.sss.s.s...................DD........Dssa	..............................................................................MsspEppLI-sLFsRLppApst.......................sRDspAEthItptlppQPsAsYhhsQslLlQEtALcphppclppLctpltt..................tptttttuuGGFLu..ul...........FGuuss.p......stPss.tssts......................sshsttt......s.......................psshsts...............ts.................uGFLGuAhpTAAGVAGGh....lLusulsuhFstppt.tthsthhtt........................t..tss..............ps..ss.hss.hh.sssss........................................cpst..s..........ts..tDss.sss.s..................s......................................................	0	25	56	86
+9682	PF09850	DUF2077		Uncharacterized protein conserved in bacteria (DUF2077)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3455)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.90	20.90	21.30	21.70	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.17	0.70	-4.92	122	1603	2009-01-15 18:05:59	2007-07-30 15:21:13	4	8	979	5	300	1102	33	200.90	26	64.69	CHANGED	NsLlss.ussLlthlspl+p..tsptssh.tplcpplhp..plpphcpph.pptuh......stpplhsu+YsLC.shlDEslh.sos....Wutpu.....tWtppsLhspaas-s.GGE+hFphLpclh..ppPtpphclLElhYhCLsLGFcG+Y.ph.tpGpp..plcplpppLhphlpph..........t...t....sl.ssphpssststpph.ptt.hPhW.hhhulss.hlhhshahshphhL	.............................................psllss.spsLlthlhplpp......htstsps..ppl...tpplhp..plpthcpth..pptuh...........p.tppl.hsh+Ys...LC.shlDEu...sh.sss....Wusps.............................tWtppsLhspFas-s.GGE+hFplLc+Lh...ppPp..p...hhslLEhhahsLsLGF.cG+Y..pl.........tp.upt.........ph-pl...hp....pLhphlpph......tsh.....................sl..ssphttst..ss..php..h....t.........p..t...lshh..hhhshsh..llhh..hhahhhphh..............................................................................	0	50	115	206
+9683	PF09851	SHOCT	DUF2078;	Short C-terminal domain	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	Jackhmmer:B0PET9	Family	\N	24.00	15.30	24.00	15.30	23.90	15.20	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.20	0.72	-4.34	733	1938	2009-09-13 15:00:14	2007-07-30 15:22:51	4	75	1219	0	751	1854	980	30.70	31	15.57	CHANGED	htspLcpLccLhspGhIoc-EFcppKpcLLs	...........ppLcpLccLhspGhIoc-EappcKpplL...........	0	286	560	699
+9684	PF09852	DUF2079		Predicted membrane protein (DUF2079)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3463)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	22.00	22.00	22.10	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.56	0.70	-5.77	53	276	2012-10-03 03:08:05	2007-07-30 15:24:01	4	2	206	0	118	317	177	416.90	18	80.11	CHANGED	Rahsh.......ssuaDhGlFsQhlaphupG+.h.hSohps..................ptLGpHhs.llhlhs.....P.lYtla.Ps.hsLhllQshhluhuulslatLAppt.t.s........pphuhhlshlahht.sslh.ss.sL.asFHs.shhh.Phhhhulh.uhpp........c+hhhhhlhhlllLhs+-shulslhulGlhlhlp.................c..............h................uhshhhhuhsahllsspll........hPha.sst.t....hhhtt.....................au.hh.......sushpllhshltpPh.hhhptlht.......slhY.llhlhlPhhalshh..........s.shLlsulPllhh.llu.stss.hslsa..+Ysh.llPhlhlusl..shpptp......................................phthhWssshhLuLshshhhs..................................hsYhshhpphsps...ppslshlP.ssuuVhss...........s.LhPpLup..Rpslhhhsts....hp..........t...pph-allls.........t..shtsstct.pphlsphpppspaphhht...psGlhl	..........................................................h........suaDhGlFpQhhh.hs.p.tp...hsshpt..................phhusHhs..lhhlls......s.lYhla....Ps...s.h...hLl..llQshhl..uhuulslahlupph..h.s...............................pthuhhh..uhsYhL..sslh...ss..sh.hs.....FH...shuh..Ph.lhhuhh..shtp.............pphhhhh...hhs..hhllhs+-.....s.h...ulh..lhs.h...Gl..hlhht......................................................................................p.......................p..th................................uhhhhhhuhsahhlshtll........hPhhtts...............................as.hh....................................suhht.hhhshltpPh..hhlttlhs.s........................plta.llhlhhshhhlshh............pshhllsslPh.lhhphlu.s.s.....hshhh...pY.shslhPh.lhhusl...shtphp.................................................................................................t.h.hh..hh...shh.....h.h.h..shh.hhhhhs.................................hhhp...hppht.th...pphls..lP..ssusV...hss...............s.lhstLst....+p.lh.hh.tt......................t.callls.................................h................h.......................................................................................................................................	1	38	74	102
+9685	PF09853	DUF2080		Putative transposon-encoded protein (DUF2080)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3466)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	21.00	21.00	21.00	21.00	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.36	0.72	-4.23	6	51	2009-01-15 18:05:59	2007-07-30 15:25:35	4	1	29	0	24	55	12	47.10	31	78.22	CHANGED	lpIpKcoW+Ks+phhsoFhshVpshGNSAplD..lPKEYlGKTVhlTll-cD-	....................t.h..pth.s.ha.tpVp.hGNSA+ls..lP+-alGKplhlsllcpp........	0	10	15	20
+9687	PF09855	DUF2082		Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3478)	Family	This domain, found in various hypothetical prokaryotic proteins, as well as some Zn-ribbon nucleic-acid-binding proteins has no known function.	20.60	20.60	20.60	20.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.21	0.72	-4.13	18	259	2009-01-15 18:05:59	2007-07-30 15:27:38	4	2	254	0	56	152	85	63.10	45	87.63	CHANGED	atCPKCGsssa-psplpsTGGshSKlFDVQNc+FhsloCppCuYTEFY+....upsSshtNlhDhhhu	..........sC.KCGs.....p.....pYtscphp..u.TG.Gshu......K....l..FDVQN+.+.Fl.....ol......o.......CspCGYT.ElY+......upoSsuhNlLDhhhG............	0	22	40	48
+9688	PF09856	DUF2083		Predicted transcriptional regulator (DUF2083)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3800)	Family	This domain is found in various prokaryotic transcriptional regulatory proteins belonging to the XRE family. Its exact function is, as yet, unknown.	21.30	21.30	21.40	21.30	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.06	0.71	-4.57	67	753	2009-01-15 18:05:59	2007-07-30 15:28:12	4	8	475	0	213	613	820	153.00	46	32.83	CHANGED	TLQRPGA+GlPFFFlRVDpAGNloKRh.SAosFpFuRaGGuCPlWsVHpAFtp.PGcllsQluchPDG....ppYlslARoVspssuuastss+phAluLGC-lpaAsclVYAcGl...........sLssssu...sPIGhuCRlC-RssCsQRAhPPls+tLtlDppppuhsPY	...................................TLQRPut+GlP.FhFlRlD+AGNloKRp.SA.suFpFuRhGG.sCPLW....sVapAFs......p.PG+..ll..p.Q.lAph.P..D.G....pp..Yl.hlARTlpp.ssuu.as.tPs.+paAluLGC-lpHApclVYusGl...........................cls..ssss...sPIGsuCRlC-RpsCsQRAhPsls+tLslDpptpsh.PY..........................	0	47	134	177
+9689	PF09857	DUF2084		Uncharacterized protein conserved in bacteria (DUF2084)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3811)	Family	This domain, found in various hypothetical prokaryotic proteins,as well as proteins belonging to the UPF0386 family, has no known function.	21.50	21.50	22.30	50.10	20.80	21.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.70	0.72	-4.28	25	284	2009-01-15 18:05:59	2007-07-30 15:29:07	4	1	276	0	48	145	6	84.50	70	98.69	CHANGED	MNISKsEQRlLHlLAQGGcIphpRs-sG+lsclpChTR-GahLusCoLsVFc+LK+KRLIpScsGpPYRITcpGLpsVRuQLDNR	.....MNLSRQEQRTLHVLAKGGRIsHlRDuSGRVTuVECYSREGLLLuDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNsVRAQsDNR............	0	15	25	35
+9690	PF09858	DUF2085		Predicted membrane protein (DUF2085)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3815)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	26.10	26.00	24.00	21.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.35	0.72	-3.91	24	150	2009-01-15 18:05:59	2007-07-30 15:29:42	4	2	123	0	61	129	105	88.10	34	60.70	CHANGED	hCHQhs-RSaahtGpQhPlCARCTGIYlGhll....shlhh.......hthhshslhlhllhhlP.hslDGhsQhhs...............hhcSsNh.......LRhlTGlhhGhuhshhl	...............CpphspRohhhhsh.hslCARCsGhhlGhlh........hhlhhhh.........hhh.h.h.h.slhl.sh....h.h..h.lP.hhlDGhsQhht..................................htpSsNh.......LRllTGlLsGhuhuhh................	0	26	46	56
+9691	PF09859	Oxygenase-NA	DUF2086;	Oxygenase, catalysing oxidative methylation of damaged DNA	COGs, Finn RD, Sammut SJ	anon	COGs (COG3826)	Domain	This family of bacterial sequences is predicted to catalyse oxidative de-methylation of damaged bases in DNA.	25.00	25.00	25.40	25.20	24.30	21.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.06	0.71	-4.94	42	288	2012-10-10 13:59:34	2007-07-30 15:30:15	4	1	258	0	107	277	10	168.60	57	71.64	CHANGED	RGEY+YFsYPLPchltpLRsuLYP+LsPlANRWspphGhssRaPsphs-aLspCHtAGQpRPTPLLLpYusGDYNCLHQDLYGEhVFPLQVslLLScPGpDFoGGEFVLTEQRPRhQSRupVlsLpQGDullFsspcRPVpGsR.GhYRVshRHGVSclRSGpRaTLGlIFHDA	...................pGEY+YFsaPLP..phlppLRpuLYP+LsPlANcWttthGh.-spaPsshscaLtpCHsAGQsR....P....TPLlL+YGsGDaNCLHQDLYGEhVFPL.QVsllLScPGpDFTGGEFVLTEQRPRhQSRup..VlsLpQG-..ullFss+cR..PVpGsR.G.hYRs.....slRHGVSplRSGpRa.TlGlIFHDA......	0	31	58	87
+9692	PF09860	DUF2087		Uncharacterized protein conserved in bacteria (DUF2087)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG3860)	Family	This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids [1].	22.40	22.40	22.70	31.70	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.34	0.72	-4.22	55	586	2009-01-15 18:05:59	2007-07-30 15:32:31	4	10	465	0	149	460	21	72.10	36	40.26	CHANGED	G+LpphP.u..+pp++lllLphlhppF.c.sppYoEpElNpllpph..a.s.DaAhlRRtLl-hGhlpRp.tGutY.......Wpt	.........................G+LpphPp....+pK+Kll....lLpclh.p.c.h.css..ppYoE+EVNp.hlcph..........as..DasslRRhLl-aGalcRst.GstY.......hh.............	0	64	116	134
+9693	PF09861	DUF2088		Domain of unknown function (DUF2088)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3875)	Domain	This domain, found in various hypothetical prokaryotic proteins, has no known function.	23.30	23.30	23.30	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.92	0.71	-5.30	50	648	2012-10-02 00:55:42	2007-07-30 15:32:58	4	4	416	2	239	630	126	196.70	26	45.88	CHANGED	YGcs..plplplP-cplhullpspt..htshtctpphlpcALpsPIuopsLp-llpst..c+lsIlsSDhTRP.sPs.......chhlPhLlccLpt.Gl.-csIpllsAhGhHRtpTcEEhtphlG......p-lhpch....cllsHsspDcsshshlGpos..............pGsslhlN+hssEADhlIssGsIp.HaaAGaoGGpKulLPGlAuhcTIhsNHsh...hl.ssputhG	....................................................................pt.....h.l..t........thh......t..............s..tthlpp...ulp.p.Plss..................Lpchsps....t..........cplsIlssDh....TR....s..sss.......phll.shllccl.pp....sh.ptp.l.tlls.AhGsHRst.Tc-.Ehtphl.G......pc.lhp.p.h....pll.sHpspsppshlpl...G.p.ss........................pG.sslhlN+hsh..E..u..D..hlIshGhlpsH..h.a...u...G...a...SGG.tKslhPGluuhcolttsHsh.hl.t........................................................	0	137	205	230
+9694	PF09862	DUF2089		Protein of unknown function (DUF2089)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3877)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. This domain is a zinc-ribbon.	29.10	29.10	29.20	29.80	28.30	29.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.26	0.71	-4.28	18	297	2012-10-04 14:01:12	2007-07-30 15:33:38	4	2	274	0	103	262	1	98.50	33	87.76	CHANGED	CPVCGcchpVT+LcCspCsTsIEGcFclscFspLopEphpFlclFlKsRGNIKElE+ELGISYPTVRs+L-cllsALGa............psps-tpsc+c-lLccLccGEISsEEAlchLK	..............................pt.t.h.l.ph.h.t..s.h.lpspFt....s.................h..hspLspEchpFlchFlpspGslKElp+phulSYPTVRsRLDclIpplsh....................tpt.t.t....plhp.l..ptpls.ptA......................................	0	52	76	92
+9695	PF09863	DUF2090		Uncharacterized protein conserved in bacteria (DUF2090)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3892)	Family	This domain, found in various prokaryotic carbohydrate kinases, has no known function.	21.40	21.40	21.40	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.98	0.70	-5.58	34	447	2012-10-03 05:58:16	2007-07-30 15:35:24	4	3	431	0	108	433	338	300.60	50	48.52	CHANGED	ELsaaLpcup..phs....c.cpDtpLp+LHtsTsR+.......ppWspLplhAFDHRtQLt-hAtpsGushs+IsshKpLhlcAutpVsp.....Gh...thGlLsD.spa..Gp-ALppAoGpGa.WIGRPlElPGSRPLchE..tGtslGupLhcWPtEHVVKCLsFYHPDDsstLRtcQEpplpcLapAs+psG+ELLLElIs.....Pcs.....tPhs.DsshhcslcRhYsLGlhPDWWKLtPh.ospuWpplsslIpc+DPaCRGlVlLGL-APt-pLtsuFtsAAs.slVKGFAVGRTIFu-su+tWLsG-lsDtphlscltspatpLlshWcptR	.................................................................................................ELs.aLtRup..phs....RPDtDspLsHLHRVTs.R+.......ppWscLplFAFDHRpQLh-....h.A....p..p....s..G..A....s.....s....+I....stLKpLhLc.Auppsutph..................Gl...pspsGlLsD.spa..GQ-A.L.N.ss...T.G.pG......W.....WI.....G..R.P.lE...hPG...SR..P..Lc..hE..+G.slGS.pLlsWPt.......E.......H.......V.......V.......KCLVFYHP-DssplRhEQEtplpclacAsppSGHELLLElI..............Pcs...............t.s.sp...-phhhcslcRFYpLGIhPDWWKLsPl....osssW.......pplsplIpcpDPaC.RGl..VlLGLDAPtpcLcsuFsuAAshshVKGFAVGRTIFu-sSRpWLuGclsDtpLIupltppYppLIshW+pt...........................................................................................................................................	0	15	46	76
+9696	PF09864	MliC	DUF2091;	Membrane-bound lysozyme-inhibitor of c-type lysozyme	COGs, Finn RD, Sammut SJ	anon	COGs (COG3895)	Family	Lysozymes are ancient and important components of the innate immune system of animals that hydrolyse peptidoglycan, the major bacterial cell wall polymer. Various mechanisms have evolved by which bacteria can evade this bactericidal enzyme, one being the production of lysozyme inhibitors. MliC (membrane bound lysozyme inhibitor of c-type lysozyme) of E. coli and Pseudomonas aeruginosa, possess lysozyme inhibitory activity and confer increased lysozyme tolerance upon expression in E. coli [1]. Structural analyses show that the invariant loop of MliC plays a crucial role in the inhibition of the lysozyme by its insertion into the active site cleft of the lysozyme, where the loop forms hydrogen and ionic bonds with the catalytic residues [2].	21.30	21.30	21.30	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.68	0.72	-4.24	101	1381	2009-01-15 18:05:59	2007-07-30 15:40:44	4	15	1175	9	224	727	37	71.70	32	55.43	CHANGED	YpCt.....ss...pplpspahsssp.........shlphss....pphhhspsh.SASGA+Y.......sss.phpa.W.sK....G.s-Ahlthttpss.........sC	.............................YpC.........sp..pslsV.phsNsppt............ssh.s.hcs.......phl.hLppsl.S.AS.GA.RY........scu...hYsaW..oK....G...cpAplhppcchsh..........................................	0	47	108	166
+9697	PF09865	DUF2092		Predicted periplasmic protein (DUF2092)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3900)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	27.50	27.50	27.50	39.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.26	0.70	-5.28	17	95	2009-01-15 18:05:59	2007-07-30 15:40:57	4	4	74	0	50	114	16	209.90	29	77.32	CHANGED	cAhplL+sMusaLtutpphShph-ssh-slhtsGQKlpauuouplslsRPD+lRssh.pushscschhaDGKTholhu.ssshYupsstsu.slD...tll-cLpschulplPhuDLhlss.shstlt.pslhsuhhlGps.slsGs.CcHLAFRps-lDWQIWIspGspPlP++hVITt+pssupPQaolphpsWshss.shssssFsFpPPssAcpl-h..ssh	.....................................A.plLcpMusaLtstcshohshcssh-.lhtsG...pKlpasu...ssplplpRPs+LRssh.pGs..tsst.....c..hhaDG+s.hTlhs.stshYuphssPs.ol-...ph.l-plppchulphPh.uDL...l..hss.shsslh.sslpsuhhlGps.hlsGstCcHlAFp....pps.hD..aQlWIspGspPLPp+hlI.T.+sh....sup....P.......Qassphp...sWshss.phs.sssFsFpPPssApplchh.h....	0	14	29	41
+9698	PF09866	DUF2093		Uncharacterized protein conserved in bacteria (DUF2093)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3908)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	26.80	63.90	24.40	18.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.13	0.72	-4.78	30	196	2009-09-10 21:13:40	2007-07-30 15:41:37	4	1	191	0	75	146	668	42.10	57	55.22	CHANGED	llpsGsaVhCAVTGppIPLD-LRYWSVc+QEAYss...uptuhpR	..llpsGoaVpCAVTGtsIPLDEL+YWSVsRQEsYAo...sthuhcR......	0	19	44	55
+9699	PF09867	DUF2094		Uncharacterized protein conserved in bacteria (DUF2094)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3913)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.80	20.80	23.80	27.20	18.40	20.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.72	0.71	-4.28	33	490	2009-01-15 18:05:59	2007-07-30 15:43:05	4	6	421	2	119	397	5	130.00	25	47.21	CHANGED	GaaGKlPutGDFVp+pLPpuhlpsWDsWlppulssspp..thsttWtpsahsuPlWRFslssulsG....tshsGllhPShDRVGRtFPLslssslssss.....s.hhhstssaaptlcshhluslctsssh..-tLspuLssLssP	..........................uaaGKlPutGDF.l.ppths.thht.hctWhttu.hth.tp.....t...t.ht.tsappsssWpFshssuhhs....tthlsGslhsSpDpVGRhaPlllhpthshpp.h......spthttstt.ah.ttltphhhptlp.spt.h..tthtptltth...h..................................................	1	19	49	81
+9700	PF09868	DUF2095		Uncharacterized protein conserved in archaea (DUF2095)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4003)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	39.40	31.50	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.80	0.71	-4.36	3	25	2009-01-15 18:05:59	2007-07-30 15:43:31	4	1	25	0	21	28	1	109.50	47	90.30	CHANGED	EKKKKPIDELPWQEYDIEEFKc+FPALARELEE-hG.LEIoGIRLDEYQVLEEEEEE.KIDFSGYNPTIIDFLRRCDTDEEALEIINWMEE+GEITPEMAKELRVTLVHKGVRAFGPKKEWGWYERHGKH	..................pY-h-EF+c+aPtLA+El..-tpu.l.Ips.phs.......-.......sauGYsPTVIDaLRRCcT-EEALEIINahEc+GEIopEhAc-LRhpLs+KGVRuFGs+KEhGaY.ER+u..h......................	0	4	9	14
+9701	PF09869	DUF2096		Uncharacterized protein conserved in archaea (DUF2096)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4010)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	22.50	22.50	22.50	140.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.87	0.71	-4.38	7	27	2009-01-15 18:05:59	2007-07-30 15:43:47	4	1	27	0	19	25	2	169.20	39	95.52	CHANGED	l-pQWVVLsELsocL.p+uh.VPp-VhpcLRhApsllsaYhhD.Hs..shc.Ltcs-+.LsplQthLhsls-...sDhsccal-Kht+AhRsEhshc.PhppSpFp..lp+....tss-sIRVph.c.lp.EhLt-luEapGVIhEh..--sDh.VhI.Gs+-clppALK-hu.h...W+p	.lDppWlVLsELsocL.p+shtlPcplhpcLRlApslIoaYhlDsHs..shcsLpcsE+pLsplQthLhsLs-...t-hsccaLpKht+AhRuEhshcFPhp+SpFp..Vp+....ssh-slRlplpptlp.ERLt-luEapGVIhEa..E-csp.llIcGsc-+lppALK-hush...WK...	1	4	9	15
+9702	PF09870	DUF2097		Uncharacterized protein conserved in archaea (DUF2097)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4013)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	36.90	60.60	23.90	20.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.79	0.72	-3.90	8	32	2009-01-15 18:05:59	2007-07-30 15:44:29	4	1	26	0	22	31	4	88.80	31	93.27	CHANGED	hclIch.......osEEhlEYl+cNVc.sDhlElsauRlalsGcVlshss........shlpLpl-uchh.Glh-lDlccIp-DlLElhHhsc-G-phlll	........c.lph.......ss--hlEYlcssVc.sDhlEl.asRlal.Gcllshps.........shhplph-schh.sh.lElDlccIp-DLlElhHhsc-scctll.h....	0	5	12	18
+9703	PF09871	DUF2098		Uncharacterized protein conserved in archaea (DUF2098)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4014)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	56.50	56.30	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.10	0.72	-4.05	16	48	2009-01-15 18:05:59	2007-07-30 15:45:13	4	1	48	0	38	46	2	90.10	31	91.83	CHANGED	c.IclGshVRYlsTGThGpVpcI.KsEsscpWllL...-sosLaYcschLEls-...tp++pc+..chst-Ehl-+l+ccc.-thpphDlssssss.....GGG	....IplGshVRYlsTGThGcVscI.Ks-...ss.cpWllL...-sosLaY+schLElh-...tp+cccc.......ctstcEhl-+lcppc..c.....thpthchstttss...GuG...................	0	8	24	32
+9704	PF09872	DUF2099		Uncharacterized protein conserved in archaea (DUF2099)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4022)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	226.80	226.60	18.00	17.60	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.36	22	64	2009-01-15 18:05:59	2007-07-30 15:45:37	4	1	51	0	50	63	6	256.00	45	90.71	CHANGED	HlhEslG+s..RVll+sG..KVlEVu-PtlcaCPLacKhR.GlcclTpEsl+cNlEaRIc-FGMhTscRplchc.sFVuFGsSElhhTuLppGhlDAsVhVCDGAGTVlsssPpLVQGlGGRhSGLlcToPIsEVIc+IccpGGhVL-.psApID.ltGlctAhchGY++lAVTlusspsAcp..lRcht..................pssclhlhuVHsTGl.op--AccllphsDllTuCASKhIRchst.+slhQlGsulPlFAlTptGKcLlhcRh+-	....HlhEsLG+.u..RVlV+sG..KVl-VuEPhlcaCPLFcKaR.GIc.clocEsI+cNlEFRIc-FGMhTscRplchc.sFVuFGsSElhhouLpcGhlDusVhVCDGAGTVIsssPpLVQGlGGRlSGLlcToPI.-..VIc+Ic..cpsGhVLD.psAcIDQltGVc+AlchGYK+IAVTVs..s..s..c..c..AcclRclEt.................tslclhlFuVHsTGl.sc--AcplhchsDllTuCASKhlR-hst......t+slhQlGsulPlFAlTppGK-LllERh+.....	0	13	35	43
+9705	PF09873	DUF2100		Uncharacterized protein conserved in archaea (DUF2100)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4024)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	22.20	22.20	22.20	141.00	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.44	0.70	-4.87	6	22	2009-09-11 01:16:15	2007-07-30 15:46:46	4	1	22	0	16	22	0	216.40	46	98.18	CHANGED	cschSK-LI+KAlpTIS+pc+sh.h.p...p..pch.apDAcsG+IDssEhK+AlapLIEAD-YLYKoAPsH-LspEcAcEFsKlLhpspcHIs+ILupFGF.Eh.EsphclD-...suLYIVuNKKlhKsL.KplsssLNIlsTEGsL-lEDM+hlNPcIPEKALhGIEKKscIs+cpIp+hIpKlsPp+lVVVVccsDsuDELlapR....AKEL.YsAE........KLsu--IL	............chp.SKcLI+KulpTISchcp.....hh.p................pppKch..apDAKsG+IDssEFKKAlapLIEAD-aLYKpAPpH-Ls-EcA+EFsKLlhpsp+HlsplLusFGF.Eh....E.p.tclDc...sALYIVSNKKlhKpL.Ksh.ss............sLsIlsTEGsL-lEDMKhINPpIPEKALtGIcKKscIsKcpIp+hIpphpPsKllVVVc..DcuDELlapR....AKEL.YNAE........Klss-ElL.............	0	3	6	12
+9706	PF09874	DUF2101		Predicted membrane protein (DUF2101)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4025)	Family	This domain, found in various archaeal and bacterial proteins, has no known function.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.36	0.70	-4.84	5	26	2009-12-03 16:38:53	2007-07-30 15:47:35	4	1	26	0	17	25	0	175.90	32	81.10	CHANGED	hKsaLlPpPS-chP+S..hlh+lsKRshTPHELlSL+LQLlFLlYLI.lSLlssa.LpshLlLIlsuslhFLYLRYlLIRNp-ahl..DFcAYRsF...YlulSTIsFlualGYlLlRcaopshaaYLsYLusIslsVllFRaYFKsRYGRDYTYGlVEEVKsDLV+VFVHDDIAANVKPGYYWVPAVu.-A-sGDIVKLLVEpRT..FRGS+PVRIL	......................................................h.ph..p.+EhhsLhLQlhhhhall.hsl.l.h...hh.h.....hhh.ht.hhYhlh..LpalLhpshshhl..ca.EsYphF....YhululluhLshhGhlllc+huhc.sh.Yhshlshlhl.sVlhhhhhF+.+ahRsaTYGhV..Eltts.hshVhVp.DltuNVKPshYhV.tss.sh..GthVKlhVEpph..h+ushPh+Il..............	1	3	5	11
+9707	PF09875	DUF2102		Uncharacterized protein conserved in archaea (DUF2102)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4029)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	38.80	38.60	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.34	0.72	-4.51	16	54	2009-09-11 09:37:18	2007-07-30 15:47:51	4	1	50	0	42	51	3	102.20	45	70.17	CHANGED	hlllusss.soPu-lshtlaplshs.lpIKETCFGshIsGcc-sVccllcclRshDss+IFsK-RGFPsGDsRRCRApRGGu.RPGFHtLEtEhplLshIucAL-	..............hlllussu..soPuclsthlapl........shs.lplKETCFGshIpGcc-hVccllcclRpl-.s+IFsKDRGFP.GDtRRCRApRGGusR.GFHtLEtE.clLshIucAL-............	2	9	27	36
+9708	PF09876	DUF2103		Predicted metal-binding protein (DUF2103)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4031)	Family	This domain, found in various putative metal binding prokaryotic proteins, has no known function.	20.80	20.80	21.00	21.00	18.90	20.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.29	0.72	-4.27	11	139	2009-01-15 18:05:59	2007-07-30 15:48:36	4	3	138	0	78	142	101	95.60	31	69.35	CHANGED	s-tssccKlGGoHSTlIGGRpGpKhlpplApHPcVKKVIPGsIsusGsu..uG.lcuKVT.RuDspGNlRLLlp-GoSVQElRlVTTAuDcEpG-clhc-LN-hL	.................h.....pt+lshsHSThlsGh..h.hLcplupp..stlcslhPGsIs.tspup..pss....lpl+lo.hsspsG.hKLlARpGsoVQElFlVTshspc-..pt.........................	0	20	51	70
+9709	PF09877	DUF2104		Predicted membrane protein (DUF2104)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4035)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	22.80	22.80	24.90	24.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.31	0.72	-4.04	8	27	2009-01-15 18:05:59	2007-07-30 15:49:00	4	1	27	0	17	25	0	96.20	44	94.03	CHANGED	hl.FhlLlsslsFIlGShlGLpYSY+KYscPalE+plDslALllAVlGhl.lhVNss......hhhhlGhhhluaslGMRPGYGRhEhllGlllAlIlalLpt	........h.hLlshlsFlIGShlGLtYSY+KYspPal-KplDhlALllAllGul.hhlNss...........h.luhhhluFslGMRPGYGRhEhhlGlllAlllallh.h..	0	4	7	13
+9710	PF09878	DUF2105		Predicted membrane protein (DUF2105)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4036)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	25.00	196.40	22.50	24.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.50	0.70	-4.76	10	32	2009-01-15 18:05:59	2007-07-30 15:49:21	4	1	32	0	21	29	0	216.30	50	96.77	CHANGED	M-hshplapsslhsGlIlGhluLlsIuh....pKsDLshlllTDLlEhuMLVlIAuVGTDLAEALILPGLVVGlAELLAVSElhluR..........................p.+lhEchsl.phss..........h+hEVLcTAPsFlAllLVVYGllLoGFTGGAVAusGLLFYhLo++spsh.h......hpaEGIuulSGIuWALWIhGFlhFFlaPptWLhuLhlAGsG.lllKVuSKlGLIGslhc	.......phh..lapsslhlGhllGhluLhuIuh....pKsDLphLlLTDLlEhAMLllIAuVGTDLAEALILPGLVVulAELLAlSEIhloR..........................c.+lhEchhh.phss...........hchEVLpTAPpFlAl..lLllYGslLSGFTGGAVhuuGLLFYslS++shGh.h......hpWEGluulSGIAWAlWl.hGFlsFFlhPphWLhsLhlAGhG.LllKVuSKlGLIGhlh.c.	0	5	11	17
+9711	PF09879	DUF2106		Predicted membrane protein (DUF2106)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4037)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	193.50	193.30	22.70	17.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.85	0.71	-4.88	9	32	2009-01-15 18:05:59	2007-07-30 15:49:49	4	1	32	0	21	29	0	151.80	54	93.62	CHANGED	tpls+lhNhlSpPcsls+laAhhlsllhllGlh.lPh.shpcsQLYPKs..p.QlphposLAPYDRGGlPLppPuslKuQYPp.pPhlGhlTAYLoPluhalu-pThYhGTTIVSpPGGIlDEILYYTRGhDTVLESSILhhuFsIhSaLahscs	.h.pls+lWNhLSpPcslsRlFAhhlslllllGlh....lPh.shsssQLYPKsh.QpQl.hcoPLAPYDRGGlPLccPAslKuQYPpapPhlGpITAYLoPlAhalucpThYFGTTIVSoPGGIlDEILYYTRGhDTVLESoILhlSFhIhSWlahN+.s.	0	5	11	17
+9712	PF09880	DUF2107		Predicted membrane protein (DUF2107)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4038)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.50	25.50	26.30	46.90	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.51	0.72	-4.09	7	32	2009-01-15 18:05:59	2007-07-30 15:50:03	4	1	32	0	21	28	1	73.70	52	88.98	CHANGED	hYsGhhllIlGolusshGPtspDPlhRhlNhElPAhGVsLlhLuYNcsLALlTFluVsslhThVLlRAIlR.Etht	.hYlGhhLlIlGoluslhGPts+DPlhRhLNhEVPulGVsLIFLuYNcTLALhTFlAVsAllTLVLlRAIl+.EEh........	0	5	11	17
+9713	PF09881	DUF2108		Predicted membrane protein (DUF2108)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4039)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	29.00	29.00	69.70	69.40	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.15	0.72	-4.16	9	32	2009-01-15 18:05:59	2007-07-30 15:52:31	4	1	32	0	21	29	0	72.30	44	80.92	CHANGED	M-hLs.lluhsssll..GuluslLtpcslsKlIhhullpuGhlsllsuttYLDVAhssuLl-PluTIllLlhhhK	.......h-lLs.l..lussssll..GulGsIlpscslsKIIMhulL-uGhlslIsuhhYLDVAhluulh-PluTlILLlulhK.	0	5	11	17
+9714	PF09882	DUF2109		Predicted membrane protein (DUF2109)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4040)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	23.10	23.10	89.40	89.20	22.30	21.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.46	0.72	-4.04	10	32	2009-01-15 18:05:59	2007-07-30 15:52:45	4	1	32	0	21	30	0	77.90	46	91.52	CHANGED	llplllGlIullsulRlhls+sRupKL.YLNslsFuIAuLIALhlcoPhGhlAAssYFIsSTloSNAIAaTlucl-ch	....lphllGlIullhslRlhls+sRApKL.YLsslsFsIuALIALYIcoPhGulsAhsYFIsSTlSSNAIAaTlsclcc.....	0	5	11	17
+9715	PF09883	DUF2110		Uncharacterized protein conserved in archaea (DUF2110)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4044)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.40	20.40	20.40	21.50	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.33	0.70	-4.72	10	44	2012-10-03 20:18:03	2007-07-30 15:52:59	4	1	44	0	33	50	1	227.00	42	95.66	CHANGED	lsTppalhG-sp-Rul-uLcohVpN-LG-LDVca.clulpcDsaspVTLsG-DsElAtNLLpEcaGElssph-s...G-lYlGpLpSas--GaslDl..GlsVplPuDEL.sLGp.......G...oPcQltcRFGLVpHLP..lRhlcspc......t.ApLo-pphD+La-Wp+..u.ssRlsVNSsTRuEl+uslNRAGHuRDIlslERLGLLEpuVVC+EcTDuPGllAsIGPYLpu.............Eltsl	.............................lshh.hl.GDs.-pul-uLcohlpNtlGDL-Vca.clulpccsaspVolpG-DpplutNLL+EEaGEls.clcs...G-sYhGpLpuhs-sGaslss..GhhlplPsDcL.sLG...........GsscQltcRFGlVpHLP..lchlpspc...............tupLo-cphD+la-Ws+..s.ssRl.V...NusTRucV+usls+sGHu+DlhplERLGLLEpullC+-sTDsPGllAsIGsYL..u.Eltsl.....................................................	0	5	17	26
+9716	PF09884	DUF2111		Uncharacterized protein conserved in archaea (DUF2111)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4048)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.90	20.90	21.00	104.00	19.90	20.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.72	0.72	-4.16	17	50	2009-09-11 16:51:47	2007-07-30 15:53:10	4	2	46	0	37	50	5	83.10	50	53.86	CHANGED	lHpLlstLPVThRStppsGlRlEcGcVlDcsYTGPVLEpVLcsucll+ssP.sGsYcGlPVlVuPI+sc.GclluAlGlVDlsu	..lHpLls.LPVThRS+s+sGVRlE+GcVlDcsYTGPVLEpVlcpucll+ssPhpGsYpGlPVlVsPI+sp.GcVluAlGlVDlTu.	0	9	22	29
+9717	PF09885	DUF2112		Uncharacterized protein conserved in archaea (DUF2112)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4050)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	168.70	168.50	20.10	17.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.65	0.71	-4.53	18	54	2009-09-11 09:55:49	2007-07-30 15:53:23	4	1	50	0	40	52	5	144.40	58	92.47	CHANGED	hKVhIYPsNSLILuDLVERFGHcPLshsppI+c+Vpsss........lDSPPhNlTsEDPK+GLKYAAlEVPSGVRGRMoLhGPLIE-AEAAIIlsc.us.............huFGChGCARTNELshaLlRcKsIPlLELcYPcs---uhphVp+IspFLcuL	.hKVFIYPsNSLILuDLVERFGHcPLsltptI+c+Vpssp........lDSPPlNITsEDPKKGLKYAAlEVPSGVRGRMuLlGPLIEEAEAAIIhpc.AP.............huFGChGCuRTNELshaLlRc.K.sIPlLElcYPps-E-uh.hVp+IspFLcuL.	0	8	26	34
+9718	PF09886	DUF2113		Uncharacterized protein conserved in archaea (DUF2113)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4051)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	19.50	19.50	19.50	176.30	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.02	0.71	-5.16	17	52	2009-01-15 18:05:59	2007-07-30 15:53:35	4	1	52	0	38	49	4	184.00	33	96.99	CHANGED	h.VEss.-ctGsphYccIhpssLpDLsLs+sIt+l+halcPctPlFlhsslh+psspsI+ltDlAslp.........spsthplpIs-EsYlsplLcpLWpphG+splcQPsRaplhlssshs........lt-hlVtDPpcsLhcclhDhh.RlhPEGFRVR+pshpssphshlASEcslpp-hh.chstchhcch.tttt	..hhVEst.-ctGtchYccIlpssLpDLsLs+uIt+l+hhhcPccPlFllullh+pssphIplpDlAslp........tspsthplpIp-EsYlspLLc+LWph.ucsplcQPsRapll..lcschs..........-hlVhDsccclhc+lhDhh.RlhPEGFRVR+.hhpspplshlASEcslccEhl.ccstchhccl.p..s....	1	8	24	32
+9719	PF09887	DUF2114		Uncharacterized protein conserved in archaea (DUF2114)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4065)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	612.40	612.20	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.35	0.70	-6.15	17	54	2009-01-15 18:05:59	2007-07-30 15:53:53	4	1	54	0	38	54	6	449.10	58	91.99	CHANGED	KP..YaIVASVElGNTTTKCILTuTNL-TG+oYllsKsV+MTRDVRsPKsGEElFG+Tl.GsELT+EuVuELV+DTLlcuhKcApLsIcpDLcFVVRSTGVsAuFsSP--VGphIhALAsGCLtAGVPP+KMTPsMohsslPc+lccaShhDKlhFDGAVsGVlPP...TGhEhVANEMEGELsTAGIK.GAKWTsVDFRNPClSlDFGTTLsGRITsD.....ppPYAKTlGNFCGLAGAIPDAIlRGoGlVDccsGsALDla.......tphptphspchsccYu-csH.EhIcIccVPtsRcRFGpVPVsscuAccuGlsLIGCDsGcNGSclscLpcIGt-lhccpultsLhtslDhVsAplshRLl-lAhccsll..pouIGlTGRAGIoGpKPcLIL-tlt-h.tlacpsp-clVFVDDGLARGAAlMARCMNSLGTPcsPlGGhRGGtCIhupRIKhp+	....pPYYIVASVElGNTTTKsIlTATNhcTG+TYllsKsV+MTRDVRsPK.GEcVFG+TlhGlELT+EuVuEhV+-TLlcuhccApLsIc.DLcFVVRSTGVsAGFuSPEEVGphIlALAsGCLtAGlPPpKMTPsMohpsl.PcclpcaShl-KllFDGAVsuVlPP...TGhElVANEMEGELVTAGIK.GAKWTcVDFRNPClSlDFGTTLAGRITs-.....spPYAKTlGNaCGLAGAIsDAIlRGoslVDc+sGsALDla.......tthptphspchsccYA-chH.-hIpIccVPpshcRFGoVPVsPcuAccuGssLIGCDVGcNGSclscLp-IGt-I..hccpslssLhsslDhVsAplspRLl-lAh-cGllptsouIGlTGRAGITGcKPcLILEtlp-h.tla.cp.p-clVFV-DGLAhGAAVMARCMNSLGTPcsPlGGpRGGtCILupRhKhQp..	0	8	24	32
+9720	PF09888	DUF2115		Uncharacterized protein conserved in archaea (DUF2115)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4066)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	51.60	51.40	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.12	0.71	-4.14	19	67	2009-01-15 18:05:59	2007-07-30 15:54:01	4	1	42	0	51	66	4	160.70	27	89.85	CHANGED	hspp-LhphLtcpsppaolhDLhphpshhcc-hchlPtcYRcchhpshhphhhtsapcl+s..psss.hpspc..hDptphpchhshl....tptp.ppttpt..........h.hlhhllssYhhFlpccPhHPVGh.FPGGhpV.c+sGsYYCPl+-+pp-schulCpFCsu+pss	...........................ppt-LhphLtcpstphSlhDlh.hpshlcp-hphlP..ppY+cphhpt.hhphhhpshpcl+p..ppspthp.tp..h-tcphpchhshl....tp.t.pt.ppstcpp..........applh.hllssYhhFlhccPlHPlGh.FPGGhplhcc....sspYYCPl+c+..ppc.thulCpFClscp.....	0	10	36	46
+9721	PF09889	DUF2116		Uncharacterized protein containing a Zn-ribbon (DUF2116)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4068)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.  Structural modelling suggests this domain may bind nucleic acids [1].	21.80	21.80	21.80	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.22	0.72	-4.17	9	52	2012-10-03 10:42:43	2007-07-30 15:54:15	4	3	49	0	35	57	35	54.30	30	67.66	CHANGED	EsH+HCllCGtuIP.-EphCS-+CpEtapp+pK+hh+pp.Ihashhllhlulahhhsah	......H+HChsC.G.tsIP..s.....-..csFCSpcCccpatpcp++.h.p.p.hhhhhhhhhlhhhhhh......................	0	8	21	31
+9722	PF09890	DUF2117		Uncharacterized protein conserved in archaea (DUF2117)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4069)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	29.00	28.30	20.80	18.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.46	0.70	-5.14	16	49	2009-01-15 18:05:59	2007-07-30 15:54:38	4	4	43	0	37	49	2	210.00	37	57.38	CHANGED	sDllsLLNaGKohpTG+sFGchVssR.....st.c.KPLIQIERPGpsDGslIsWN.......cts...pshs-cLScpLsLsh.p........hppslsptpshppsp...plhR+lsGV.PGEsIhVNGIVIG+AsSscVplluEN.GhlssIpGGpIKcHGlEKLtc......VDLp+AhVKTG.hlR+ss........hpschhc.cshstch..............s+VllIDHAAEcshEhh..csAshVlTlGDDTTsIuGD	........................................................DllhLlNaGKSt.TG+sFGphVspR..................sthpcPlIQIERPGctDGslI.WN......................pts...pshscpLocpLsLp......................ppslspthshh.ppp.....phhRclpGVpsGEsIhVNGIVlG+.upuscVtllucs.GhlscIhGGplKcHGlEKLtp......lDLpcAllKTG.hLRRps...........hpschtp.....pshspph.............................sclshlsHAuEcsh-hh....cc..sshVlTlGDDTTtlsGD...................................	0	10	21	29
+9723	PF09891	DUF2118		Uncharacterized protein conserved in archaea (DUF2118)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4072)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.64	0.71	-4.50	9	43	2012-10-02 20:27:15	2007-07-30 15:54:49	4	1	43	6	31	71	34	148.80	31	94.63	CHANGED	h+lP+lYVEstts-................t.cVhlcps-chhhah-cscthhh.GKslYph.hc-hsD.lhtp+hp+chlIhhP..DtRphlalKcGocLh.lPsEGapVs.IschGsRVtcGsslAslpT+KG-lRalcuPVsGsVValpE.Ps....tRssYlaYIlPE	............................................+lPcLYVEs..p-.................s.cVhlcpstph.....tF.....l-h...s.c......thhhtt...KhlYch.acpas-.hhtsph.ppDhlIhhP............ct+phhal+cGsc.Lh.lPsEGapVh.IsshGsRVccGctlAslpT+KGE.lRal+sPhsGsV..lalpEhss....tRspYlaYIL.E...................	0	10	13	21
+9724	PF09892	DUF2119		Uncharacterized protein conserved in archaea (DUF2119)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4073)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	29.60	29.60	29.60	144.90	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.16	0.71	-5.02	10	27	2009-01-15 18:05:59	2007-07-30 15:55:00	4	1	27	0	18	26	2	196.00	39	94.08	CHANGED	YupG+t..Ph+LFVAGlHGsEuKsToclLcclp.schp.....GslsllP.lVcsuKYISTLcPcYYco.hGKpILclIEch+P.-hYlELHSYStENacKLTupsRhsptGVPsalsLpsGVLlGSVSPhlR++hFs+-sLCLTlElP.............pttspcut-hlsclLclltcupoR-EFIEclc++YPcpscKAhchh+cFaGp	....h.spucs..Pp+LFluGlHGsEuKhTpplLcplp....sphp..................Gplhlhs.lscp..o+YlSTLs.cYYcop.GppllclIEcYcP..chYhElHsYstcsYp+LTshcRhsppGVPPhl-LssGVLluSVSPhlRp+.Fpc-slChTlElP..................shpstcshchhhclLchhhpupsR--hhcclhpcYPcpscpAhphu+caah...	0	5	11	14
+9725	PF09893	DUF2120		Uncharacterized protein conserved in archaea (DUF2120)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4077)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	39.30	95.70	22.20	20.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.82	0.71	-4.25	6	27	2009-01-15 18:05:59	2007-07-30 15:55:13	4	1	27	0	19	26	2	138.80	38	95.54	CHANGED	lpcl.............hG+IMctl-AF+GSKPllcscElLhVRGhsR......DchhcchsSlhEaL....l-hLsccGhELls-h.............DEh...Vp......chsElhs-o-ha.D.hGFE+lKcoFEshGCssDYslG+p.cshhlhlsMWhDKsuhsPKFVEllsl	....................lhG+lMpph-AFKGSKPlhcp-plLhVRGlsR......Dc.hcchssIc-aL....h-pLsppGhElhsc..............D-h...lp......cIsE.lhs-.osha.DtaGFEtlKcuFEshGCcsDYtlu+K.sslhlsluhWhDKpshsPpFVEVhs..	0	4	9	15
+9726	PF09894	DUF2121		Uncharacterized protein conserved in archaea (DUF2121)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4079)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	26.20	26.20	141.40	141.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.09	0.71	-5.02	13	34	2009-01-15 18:05:59	2007-07-30 15:55:24	4	1	34	0	25	33	2	194.40	38	71.02	CHANGED	MSLlIuYhGKNGAVlAGD+RpIhFpGpcpsREcLEEcLYSGcI+oDEELtK+AsEauVp...IplsDs+cKVpplss.VLsGEVsol.Gt-oKRRRlYsTpGshsIl-lpssplTspohssGosllVFGN+asKclsppplK+php..hKhslccltclhcclhcpl.tcssTlScpa-lhhspsttcshct......sIc+Dlpc	MSLlIuYhGKsGAVlAGD+RpIhFpGscppRcpLE-cLYSGcI+oDEELh++AcEhGlp...lpIsDsccKV+clus.lllGEVpol.uh-oKRRRlYsTpGshsIl-lhssplsspphtpuusllVFGN+asKclupcpl+cphp...phslpcltclhcclhccl.ppTPolSppa-lhhspsthsshct......slc+Dlp.p.............	0	6	13	19
+9727	PF09895	DUF2122		RecB-family nuclease (DUF2122)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4080)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	61.30	61.00	23.50	18.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.21	0.72	-3.84	18	59	2012-10-01 22:53:19	2007-07-30 15:55:36	4	1	58	0	37	53	0	105.40	35	71.33	CHANGED	GuAAQpGlP-lhKLAhKhGp.sllVlsDlcDAlElL+P-hVhhlspsspctt.........phhc.........hcs+lhlVhsGu-.suhochElshGpslhhtulcp-lGslGtlAlhL..Ypl	.GuAAQsGlP-lpKLAhKhsK.slllLs-lcDAlElLcP-hlhhlupsuppphp........p...hp.........hts+lLllFsGs-.sGFoKhElph.Gptlhl.tlpp-lGulu.hulhLYp....................	0	13	19	28
+9729	PF09897	DUF2124		Uncharacterized protein conserved in archaea (DUF2124)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4090)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	21.40	21.40	22.30	142.70	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.52	17	49	2009-01-15 18:05:59	2007-07-30 15:56:01	4	1	41	5	34	50	1	147.50	38	93.47	CHANGED	+GlushLpsFKshl....t.psucpI.sahGssGsCsPFApLhuYulRsh..pphFlPssch-cu+plp.lsclGhp...ls-.hshc.sDhlVlhGGLAMPchsloh-csppllpclsstp....llGlCFhshFp+sGW.cpIsFDhlIDupl-.Vpl	..+GlushLcsF+shl....t.psucpI.lahGosGsCsPFApLhuYulRsp..cthFlPssch-cu+plt.hsslGhp...hs-ttshc.sDslVlhGGLAMP+hslss-clppllpclsscp....llGlCFhuhFp+uGWtcc..IcFDhlIDuplc.V......	0	8	22	27
+9730	PF09898	DUF2125		Uncharacterized protein conserved in bacteria (DUF2125)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4093)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.40	21.40	21.40	21.50	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.74	0.70	-5.12	45	259	2009-01-15 18:05:59	2007-07-30 15:56:21	4	3	225	0	86	216	94	300.50	20	82.17	CHANGED	WahuAstlcpshssWhspppupGhts-hushs....lsGFPhRhclphsssslusP.........psGhuhpustlphhu.sYpPs+llsphss.stplshs......stsasltpss.....hpushshsspssLsh-chslsstshshsssh..t.......sshsplp....hthtps..ssssshchslpspshshssshh................thpshphcuplphshs........hshsslpptpspssplclppsplph.Gshtlpu.uGslslDssGhssGclslpspshcpllshhtpsthl.t.....................................t......shpsshshhuthsGptp.slslsLphpcGplhl.GslPlGtsPs	...........................................................................................................................................Whhhustlctthps.hsp.tstGhtspttshp....hsGaPhRhplhssshphtps..........tpuhshphsthpssu.hatPhplhhthsu.Pthl.....ph..s.............hthshshhpss........hphthsh.s.chplshcssslshts.ssths............sshtchp....hp..hs......ssssshc..hth..p...hsshshssshh..........................shttsphsushs.hslssh...................................ss..p...th..h....t...p...h.ps..t...s...l...s...lpphplsh.usht.hsu.oGshsls..p......s.......G.........h........hs..GclpLplsshpslhpsht.tst.hps........................................s...........shpsh.hthhu..ths..t.st..........s...shshsltl.p.cGph.h.G.lslGthP................................................	1	20	55	65
+9731	PF09899	DUF2126		Putative amidoligase enzyme (DUF2126)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4196)	Family	Members of this family of bacterial domains are predominantly found in transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown, but they are likely to act as amidoligase enzymes [1] Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes) [1].	18.40	18.40	35.20	26.50	16.30	17.50	hmmbuild  -o /dev/null HMM SEED	819	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.37	0.70	-6.51	40	471	2012-10-02 17:21:26	2007-07-30 15:56:54	4	7	408	0	164	493	127	725.70	51	74.92	CHANGED	s-.sEV-Fpa-MpVsRltEsPRVTKPao--pWpslssLGcpVDtcLptsDVRLTMGGEPTFVSlDDh-usEWNTsAlGPsKRtLAssLl+RLRc+FA.PGGlLHaGQGKWYPGEsLPRWuhulaWR+DGpPl..W+ss..sLlAc-s....psts....ssscpAcpFlpslApcLGlsschlhPAYEDshaalh+EspLPsNVDP.tcu+Lc......DsppRtRls+VFccGLspPsGaVLPlp+hp.spss......WpSstWhhR.+s+laLlPGDSPlGhRLPLsSLPalsss-aPa.hh.tDPhpspssL.....................tttt.ssststptstpphtpth..........................thVRTALsVEsR-G+LpVFMPPl.-p.lE-YL-LluulEssApplshPVhlEGYsPPp.DPRLshl+VTPDPGVIEVNlHPAsoWcEhVchTpsLYE-ARpsRLGoEKFMlDGRHTGTGGGNHlVLGGsTPsDSPFLRRPDLL+SLltYWQ+HPSLSYLFSGhFIGPTSQAPRlDEARcDuLYELEIAhuQlPts...tsspsP..PWLVDRLhRNLLsDlTGNTHRAEhCIDKLYSPDusTGRLGLlEFRuFEMPPcsRMSLAQQLLlRALlA+FWcpPhcs.tLVRWGTsLHDRFMLPHFlhpDFtDVlsDLptsGasFcspWFssahEFRFPhhGclph.pGlcLELRpALEPWHVLGEEuusGG.TsRYVDSSlERLQVKlpGhss..sRaslsCNGRplPLpsTGssGEhVAGVRY+AWQPsSuLH.PTIslcuPLsFDllDoWsuRSlGGCsYHVAHPGGRsY-TFPVNuhEA.EuRRlARF.shGHTsGths..........................ss.tp.....ssEFPhTLDLR	...................................................-.s-spFpap.pVsRlhEsPRVT+PYo-ppWptl.tLGppVDtpLttsDVRLThGGEPTFVSlD...Dh-usEWNTsAhG........PpKRthAspLhpRL+sc.au.s...sGhlHaGQGKWYPGE.LPRWshulaWRpDGpPl..Wpss..sLlAc.t...ts.s...........................hsstpApchltslAttLGlssphlhPAYEDshhaLhcEtpLPs..s..lss......s.....s.c..Lt..............................-....p..Rtclt.chhppuLspssGaVLPlpthtst.t................WtSstWhhR.ct........+hhLlPGDSPhGhRLPLsSlsahs.t..p..h.h...h.tDPhtstssL.................................................................................................................................................................................t.hsRTALssEsR..................s.....................Gh..................LhlFhPPh..pt..lEcaL-LluslEssAp..pls.h.s.l.llEGYsPPt.Ds.RLphhplTPDPGVIEVNIpPutsWpEhsppTphLY-pA+.sRLsoEKFhlDG+HsGTGGGNHlslGGsTPuDSPhLRRPDLLtSLlsYWppHPSLSYLFSGhFIGPTSQAPRlDEuRp-sLYELEIAhupl.t.........................st.pss..PWllDRlhRpLLhDlTGNTHRuEFCIDKLYSPDus.oGRLGLlEhRuFEMP.PHs+MulsQpLLlRALlAhFWcpPhps.....LhRWGTtLHDRFhLPHFlhpDhtDVls-Lpt.tGasFcspWFssahEFRFPhhGphth..pG....lplELRtAlEPWHVhGEEus..suG.TsRYVDSSlERlQV+lp....G...hss.........pRa.lloCNGh.lPLpsT..s.psu.phVuGVRa+AWpPsSuLH.PTIsVcuPLsFDllD.s.......Ws.....tR..........SlG.GCpYHVuHPGGRsY-ohPVNuhEA.EuRRhsRF..shGHTPGt..hs......................................t........s.-hPhTLDLR.............................................................	0	45	105	133
+9732	PF09900	DUF2127		Predicted membrane protein (DUF2127)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4331&COG3305))	Family	This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.	24.30	24.30	24.60	25.50	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.51	0.71	-4.15	33	344	2009-01-15 18:05:59	2007-07-30 15:57:02	4	2	332	0	92	229	22	140.60	28	75.50	CHANGED	tuL+slAlhEusKGllslluGluLhslhtps..lpphstpllp+.........hplsPssphsshh......LphssplossslphluhhshsYuslRhlEAaGLW+s+tWupahullSuulYlPaElYElhp+s.ohhphslhhlNlhlVsalhhplt	.............................................................h.sl+slulhcus+ull.lluululh..h..ltspp..lp.thlpcllph.........hplsssshhsphh......Lctutt.lssssLt.hsushhhsYusl+llEuhGLW+t+hWupahullusulaLPhElY-....lh.p..ph.ohhplsshhlNlhlVhhhhhph.............	0	30	61	81
+9734	PF09902	DUF2129		Uncharacterized protein conserved in bacteria (DUF2129)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4471)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. Structural modelling suggests this domain may bind nucleic acids [1].	22.00	22.00	23.90	22.40	20.20	18.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.33	0.72	-4.18	38	1016	2009-01-15 18:05:59	2007-07-30 15:58:04	4	2	1011	0	95	365	0	68.40	38	76.10	CHANGED	RpulIVYLaplKps+.pLR+aGslhYhS++h+YllLYlsp-cl-plhcKlpph+FVK+VchSh+s.lcpsap	..........RpullVYLhh.+ct.+.pLp+YGcIhYhS++h+YlllYlspp-l-plhp+Lpch+FVK+VchSahptLcpsa.............	0	22	48	71
+9735	PF09903	DUF2130		Uncharacterized protein conserved in bacteria (DUF2130)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4487)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	24.70	24.70	25.20	26.30	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.55	0.70	-5.65	42	737	2012-10-11 20:44:46	2007-07-30 15:58:23	4	1	708	0	105	513	324	259.60	43	60.52	CHANGED	-...c.hhpch-pp...lcphpcpI-clK....chttphSsphhGEsLE.ahEs........hhtsuF...PpshhEcssc.uppGu.....KsDaIaRshs.......ppspchsSIhaEhK.......pTKphs-calc+LccDppppps-aAlLVS.l.Pc.......hhV-s.tthcphaVs+PphFlslhslLRpuhlphhph+ppht....hhpspth.lhpF..csphcphhpuhscsas.hpcchppthcpIsKthp+hpcph-slltuspsLphuppphssholpcl..sthpsshttc	............................hp....sthppphEsp.LKsts-plEh..hK...shK..sQtSo.KhlGEoLE.asEscFp........phcphuF....Psuh...F-KDNK..uspGo...............KGDaIaRtpD.......csGsEhlSIMFEMKNE...cto..csK+KNp-FhKcLDcDRREKsCEYAVLVThLEs-s.phaNtGIVD.so...H...p..YEKMY.....VlRPQ.aFltllulLRsuulNoh..+hK..ppLt....hh+EpNh-locF..Ec-hcshppAhsKsYpssopsatculccI-KslK+hEcs+chLssocspL......+hAs.NKlps.lol++LsptsssMtt......................	0	29	63	90
+9736	PF09904	HTH_43	DUF2131;	Winged helix-turn helix	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4519)	Family	This family, found in various hypothetical prokaryotic proteins, is a probable winged helix DNA-binding domain.	21.90	21.90	22.20	23.00	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.09	0.72	-4.18	22	301	2012-10-04 14:01:12	2007-07-30 15:59:03	4	2	275	3	56	190	6	87.40	50	91.47	CHANGED	SKopsuFhRRLYlAaLI-sspt.sVPuLhchTGMPRRThQDslsALs-lsIcspF.Q.cGtRppsGaYpIpsWGsIsctWlpp+lppIppsL	.........chpssFhRRLYLAhLl-stcpsNVPcLhctTGhPRRTlQDslpALs.slG.IplpFVQ..-...GtRpNsGYYplsDWGPlDppWltcphppItus..................................	0	5	17	37
+9737	PF09905	DUF2132		Uncharacterized conserved protein (DUF2132)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4628)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.50	20.50	22.00	36.70	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.13	0.72	-4.01	80	623	2009-01-15 18:05:59	2007-07-30 15:59:32	4	1	484	1	182	464	52	63.70	59	64.05	CHANGED	QsNNPLHGloLEpllscLVcaY.GW-tLupplsIpCFpscPSlKSSLKFLRKTsWARcKVEsLYL	..psNNPLHGloLEplLscLV-aY.GWctLupplpINCFps-PSIKSSLKFLRKT.WAR-KVEsLYL.	0	44	101	146
+9738	PF09906	DUF2135		Uncharacterized protein conserved in bacteria (DUF2135)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4676)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	22.00	22.00	22.10	22.40	21.90	21.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.40	0.72	-4.01	24	419	2009-01-15 18:05:59	2007-07-30 16:00:37	4	15	368	0	47	179	49	47.80	72	16.17	CHANGED	PhpGsYhVaVNYaGstssp.............thsssplsllos......Es..oPsEc.pcsahlPl	..PlHGRYQVYINYYGGRSET......................ELTTAQLTL..ITD......EG...SVNEK.QETFIVPM.......	0	7	24	37
+9739	PF09907	DUF2136		Uncharacterized protein conserved in bacteria (DUF2136)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4680)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.80	20.80	21.00	21.30	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.40	0.72	-3.90	64	642	2009-01-15 18:05:59	2007-07-30 16:00:53	4	2	550	0	147	444	36	75.70	38	75.54	CHANGED	cucpsLpsWaphscpApWpsPp-lKppa.ssAshlt..sp+hVFNItGNcYRLIstlsa.....phphlal+alGTHsEYD+ls	........................p.tchsLpshhshlp+upappPp-lKpha.sShDth.+....scahVFsluGNphRLluhlpF........ptp+hal+alsTHtEYD+l........	0	31	94	128
+9741	PF09909	DUF2138		Uncharacterized protein conserved in bacteria (DUF2138)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4685)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.70	20.70	21.30	22.00	17.70	20.60	hmmbuild  -o /dev/null HMM SEED	555	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.85	0.70	-6.37	14	352	2009-01-15 18:05:59	2007-07-30 16:01:41	4	1	334	0	18	175	9	509.80	80	97.64	CHANGED	KtWthhulls..AlslluusVhtlta.....tspusc+sLss....sslpl........DLscPDullDScSLSQLPKDlLpVPhL+DVLTEDFVFYYpscuDRLGlpGoLRRIlYEHDLsL+DpLlcpLhDQPApVALWRusDG+LpaahllhpRuGLAKlLEPLuhsAsuDuQLSKsthu...lsusslPVYpL+Ysus+sLhFAocsD+llsLSsPsMLacc-.......tp......sscAsslhusLLuG....+chaspuFGLts+ssp..PspQRlVVSAshLuFGYQRahPuFAGlRF-hG.s......sG...WpSalALsD.stplstpaDFsPlWpAMPuGAShCVuLPhsathApshLs+luuE...ssphs.......-tLsGsAGlCWYucS+LhoPLFVuplcusstt...chsptlGKLFspsIGAaEuKAsc..........thLPVoppppG.puplWpRpVSSRaGpYssupAspPsQL.u-hFFpVoLAhpspTLlFSLDDpLVscALssLsKpaPAhuDVlPpD..ullPLYlsPpuhApLlcpEThsSLPpDhEPVFhNAAQThLhPKLcALuphspYsLsLspshpsuuuWQWLPlpW	......................KGWRFYGLVGFGAIALLSAGVWALQY.....AGSGPEKTLSPL.VVHNNLQI...........DLNEPDLFLDSDSLSQLPKDLLTIPFLHDVLSEDFVFYYQNHADRLGIEGSIRRIVYEHDLTLKDKL.FSSLLDQPAQAALWHDKQGHLSHYMVLIQRSGLSKLLEPLLFAATSDSQLSKTEISSIKINSETlPVYQLRYNGNNALMFATYQDKMLVFSSTDMLFKDD..........QQ......DTEATAIAuDLLSG....KKRWQASFGLEERsAEK..TPVRQRIVVSARLLGFGYQRLMPSFAGVRFEMGN..........DGWHSFVALNDESASVDuSFDFTPVWNSMPAGASFCVAVPYSHGIAEEMLSHISQE....NDKLN.......GALDGAAGLCWYEDSKLQTPLFVGQFDGTA.....EQAQLPGKLFTQNIGAHESKAPE.............GVLPVSQTQQG.EAQIWRREVSSRYGQYPKAQAAQPDQLMSDYFFRVSLAMQNKTLLFSLDDTLVNNALQTLNKsRPAMVDVIPTD.....GIVPLYINPQGlAKLLRNETLTSLPKNLEPVFYNAAQTLLMPKLDALSQQPRYV..MKLAQ.....MEPGAAWQWLPITW.......................	0	3	7	13
+9742	PF09910	DUF2139		Uncharacterized protein conserved in archaea (DUF2139)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4697)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.90	25.90	26.30	26.30	20.00	25.80	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.03	0.70	-5.41	6	35	2009-01-15 18:05:59	2007-07-30 16:02:18	4	1	31	0	24	37	0	292.40	40	66.93	CHANGED	LYaTLAFEAcAaFIc.ssspc+lY-FpLVGstPsSGGDTYNAVEsVD-hIYFGGWVHAPAhaRt+scG+.AsIsFoNKYSHVHcYDTusscV+LlWKEShHc.ccWAGEVS-IIYNPYsDcLLLARtDGHtNLGVYpLD.RRGtsR+L.scPuhKGshhhDhAhFul.+pahtGhpGlcslDLlot+h....EtFs.us.SlDGGshhpP+lGuh.sSlasRlFAFV+GGlhVhNPa.GEcatFVRLhDFs.ohYuPhRsNALslGGGlLluFNuapcAshRsssE.tplhp+hTNTlluPSlLVYIAPPhVKIVGuFGARlTSlEthGsKlLlAsNTsPNstthD	..............LYaTlAFEupAaFl..pssucplYcFchlGpsPsSGGDTYNAVpsVD-hIYFGGWVHAPA.hactcs.php..thI...sFpNKYSHVHtYDhcsspVcLLWp-uhHc...c...pcWsGEVS-IlYDPapDcLLlARtDGHtNLGlYplshcsGchchLsppPoh.KGshhcDhAhF.sl.hps.........appGlptltshDhlst+.h.....-tFs.hut..ohDGtshlt.thGsh.soh.NRhaAFh+GGlhluNPh.t..-phpFhRLhDF..s.huPhRsNsh.huGGllhsaNuapcuhhpshp..t.h.hthoNslsuPolLlYlsPP.s+IVushGARlTShp.htscllluhsThsNhtth..........................................	0	10	12	17
+9743	PF09911	DUF2140		Uncharacterized protein conserved in bacteria (DUF2140)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4698)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.90	20.90	20.90	21.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.07	0.71	-5.12	28	414	2009-01-15 18:05:59	2007-07-30 16:02:32	4	2	407	0	70	269	2	183.70	34	90.22	CHANGED	NhWKhuFhs...LLAl.lhshshlsstlhtPs.p....ptsspppscucs.shslsosKcpLNpllspYLpcht.ssphsYchhl.ssplhlpGshplhGpslshhlhFcPpVhcNGsVhL+spslSlGsLsLPlshVLpYlppsYcLPcaVslpPccpplhlpLschchpsshhl+AccIDLhsD.cIpFslhlP	......................................................NhWKhsFlh...L.lul.llusssh...lssplhpsp...c.........tpts.sht..pppups.shsls..osKpplNp.llstYLp-ap.....s.pcl..p...Y.+hhl.sspshhpGohplLGp.slshhlhFpPhV.h.cNGsV.pL+spslSlGsLsLPlp.VLpalcpsY.+LPcaVplssccpplhlpLsphchpsuhhl+AcpIsLh.sD.cIpFslhh.............................................	0	18	43	59
+9744	PF09912	DUF2141		Uncharacterized protein conserved in bacteria (DUF2141)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4704)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.00	21.00	21.10	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.49	0.71	-4.41	90	328	2009-01-15 18:05:59	2007-07-30 16:02:53	4	6	253	0	136	354	294	108.70	26	65.11	CHANGED	Vplsslcss....pGplhlulass..scsa.......ptppshtstpspsss..sssplsFpsls.sGsYAlulhHDpNuNG+hDpsh.hGl..PpEsaGhSNNsp..hphG......PPsFpcut.Fsls.ttspslsI	.............................................lplpslcss.pGplhlslass....tpsa.............ttppsht...th...ps.tsss....sshplshpsls.sGpYAlslaHDcNsNs+lDpsh...hGh..PpEsaGaSssst..hh..h.G......sPsapcutFtls..tstph.........................	0	45	93	121
+9745	PF09913	DUF2142		Predicted membrane protein (DUF2142)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4713)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	24.10	24.10	24.30	24.30	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.44	0.70	-5.80	34	382	2012-10-03 03:08:05	2007-07-30 16:03:08	4	2	312	0	85	365	107	367.10	17	74.57	CHANGED	l..hhuhhhshssPshpsPDEshHhs+sh.......tl.sp...G.h......hssspsph.t.......................thttshhthhsptss.st.pthtpsshspptsshsph.s......YsshhYlstulGhhhuphlshsshhslhhuRlhNhlhashlhhhulthhsht+..hl...hhhluhlPhsla.suShssDuhthuhshhhhuhhlph....hhppphsp+...hhhhllsssLlshsK...ssalhLshlhhhls.......ttthspct......................................hhsthhsshhhslshhhhhths......pth.hhtsth............stslthllspshthht........lhhpsl.....h...phhsstF.....hGWhcs.l.s..hhhshhhslhhlhhsshsthph+.........phhhhhlslsshhhlhhhlhlshosssssh.......l.G........lQGRYalP...lhhll	.......................................................hshhhhh.h.P.....hp..s.P.DE.hHh.psh.................tl.sp.....................................hspstt.t..............................................h.ht.......t.t.t.....t.t...ht.t.h..t.t....h.sh...p..t..h..s....s..................h.shhYlspulGhhl....uphl........t..........hs....h.....hhh.h....hhuRlhNhlh...ah....h....h....h...h....h....u..l....+h....h.......ht+........hh..........hhhlull....Phsl..........s....u.ShshD...shs.h...shshlhhuhhhph............htppphstp....phhhh.hlhsh.llshsK.......hsahhll...hL.hh..hls.................hp.h.httpt.....................................................................................hh.tthh.hh.h.h.hhlhh.h....h..h.hh.hh.....................h...hh..t............................ttp...h.t..h.hltp.h...hht.............hhhpsh......................h.s..h.hhs.h......h.hGhhs.ht......l..sh..h.hh.h.h..h.......h....h.h....lhhl.hh...s.thp.ththp.............................h.ph.h.hh..hlh...h...sh..l.hhlhhhh...hls..as.shstsh.............h.G........lQGRYah.P.hl.h.............................................................................................	0	30	55	75
+9748	PF09916	DUF2145		Uncharacterized protein conserved in bacteria (DUF2145)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4727)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	25.10	69.70	18.30	16.50	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.25	0.71	-4.79	20	193	2009-01-15 18:05:59	2007-07-30 16:04:25	4	1	187	0	37	127	1	199.40	53	72.14	CHANGED	ctLsu....pGAcVsllARsGpDhSch..Gl+aoHsAaAlp...s.s-G....sWpVhpLhpcCss.spSpLap-GLu-Fah..-sshph-sulllPoPplQp+LlslLsosstt..tLHsspYSllAaPauocYQNsNpWsLElLAAAhtt...........sss...........RcpspuWL+.AtYpPssl+luhhpRLuuphhssslshcDHP.t.hhuGplpTsTssSlhpaL	.......QpLsu.psssVVILsRpGQDhSph..cLpaSHAGaAhR.....p.PsG.......sWRVaHpLNsCGT....AcSuLYhQGLhEFlu..DDLlspsluVlRPpu-lAsALpsLLpSuh+Ls.hhHuPRYsllAaPFSusYQNSNtWlLEVhAtA.-A.p...........lho...........RscA+pWLQhpGYQPSlVssGsacRLGA+LFsPNVaTDDpPuEhlhpGNlulsosDSVhcFl..............	0	8	23	30
+9749	PF09917	DUF2147		Uncharacterized protein conserved in bacteria (DUF2147)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4731)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	19.80	19.80	20.30	21.80	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.61	0.71	-3.82	158	1014	2009-01-15 18:05:59	2007-07-30 16:05:10	4	3	685	0	331	901	232	111.90	28	71.04	CHANGED	G.hWpT.......ststs..Vcltp.su.....up...lsGplhph..........................tpspsp.....hcspsllGhpllhs.hc...sssp........ap.GplhcPcsGKsYpuplpl.....pss..ppLpl+G..pluh..hls+o.QsWpR	.....................................................GhWpo.......ststs.....lcltp.ss......up.....hsGplhph.....................t.t..tppssss.........hcspshhGh.plltshct...sssp.........aptGplh-Pc..sGKs.Ypschpl.........pss....tpLpl+G...hl.u.h.t.hls+o.poWpR...............	2	94	198	252
+9750	PF09918	DUF2148		Uncharacterized protein containing a ferredoxin domain (DUF2148)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4739)	Family	This domain, found in various hypothetical bacterial proteins containing a ferredoxin domain, has no known function.	25.00	25.00	36.70	35.90	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.30	0.72	-4.25	11	138	2009-09-10 16:57:13	2007-07-30 16:05:19	4	2	131	0	61	116	3	69.00	55	39.09	CHANGED	-FsGPpCsh+hlDLGIAlGSAsKsAp.LslDNRlMYohGsuApphGhl.DA-llhGIPLSsoGKNIaFDR	............tGssCAhpslDlGIAlGSAsusAuplpVDsRVMaSsGlAApcLshl..-..sc..h..V...h.uIPlSAouKNsFFDR..	0	29	50	57
+9751	PF09919	DUF2149		Uncharacterized conserved protein (DUF2149)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4744)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	39.40	32.40	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-10.16	0.72	-3.89	29	201	2009-01-15 18:05:59	2007-07-30 16:05:37	4	1	172	\N	82	166	11	90.30	38	82.04	CHANGED	hsulsNLhDlhlVhuVuLllAlVhshsh.phh....sppshshhpssspsshphlh.+.cGpclcphp.otp....uuGpG...p+hGssYc.hcsG+lIaVP-	....ssVsNLhDlhhVFuVuLhlAlVhphshsphh....uppchshlc.s.sGcts.M..clls....K.cGpclpcapsopp.......uuupG...p+lGssYc.LcsGclIYVPE.....	0	31	68	77
+9752	PF09920	DUF2150		Uncharacterized protein conserved in archaea (DUF2150)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4749)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.60	20.60	103.70	103.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.27	0.71	-4.70	14	47	2009-09-11 15:57:27	2007-07-30 16:05:50	4	1	47	0	36	48	0	187.60	39	94.39	CHANGED	hpFYopERWpNWlsplcEsch-..s-s--suc...lhhshpDDlslAllKIlstacstpl.sc--AlscLcsl+-IVhs-st......sEDh..ll-ulQsSLlslFhAucpYltGshs.-sslcphlcsAhcAEt.--Dl-pALshsuphGutVIsGcshstchlcD..hphGLVsEWlsGlDolpsAhssscsh-E-	..pFYopERWpNWls+lcEp-h-...sEsE-su+...lLlNhpDDsslAlhKIlsta-cspl.scE-AlccLpsl+-IVLsEl-......cE-pshll-uVQTSLlslFhAAEpYlsGshst.-uslp-hlcsAs-AEt.-EDlDsALshsupsGstVlsG.ccLshphhc-..hpYGlVsEWlsGlDSlpuAMsss-sh-E-.......	0	6	29	34
+9753	PF09921	DUF2153		Uncharacterized protein conserved in archaea (DUF2153)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4755)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	23.00	23.00	23.40	103.20	22.20	22.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.53	0.71	-4.52	8	41	2009-01-15 18:05:59	2007-07-30 16:06:01	4	1	41	0	26	34	0	125.30	47	88.22	CHANGED	sL-pWVKhQKplLcolcsh-..EchcsuDRL-LIluoRsAFpHMhRTLKAFDpWLQDPhlluHMPREMLhDVpsshhclhppLLELDI+HTSpa+-LlpKhu+EGKLsPllhhh+..stpcPsRR+cu	..pL-pWlKhQ+pllpsLcchE..-phc..s..hDRL-LILuoRsAFQHMhRTLKAFDpWLpDPhlhpHMP+EMLc-lcsphh-lL.cLlELDIcHTSpaR-hlsKhuKEGKLsPllhh.h..ppppspRcp..t.............	0	9	14	19
+9754	PF09922	DUF2154		Cell wall-active antibiotics response protein (DUF2154)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4758)	Domain	\N	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.37	0.71	-4.39	37	1584	2009-01-15 18:05:59	2007-07-30 16:06:22	4	7	1195	0	260	904	13	106.40	24	44.17	CHANGED	thhGstpphpp..sapacDlNltshhGcshIDLspshlsps-ssIhI+phhGsscIlVP.DlsVplct.oslhGslphhsppp.tl.Npslphpossappst+clKIhsslhhGslEV	...............................hGp.ph..p..shph.cDlplpthhGcspIDLspsh.h.p....cp...s...s..Ih..lcthhGssplhVP.hc..hp..V..sLc.s..ss.haGssp..........t..p.....t....t..h.......p.....php...pt.h..............s....h.plp..lhhshhhGsl-V..............................................	0	99	190	227
+9755	PF09923	DUF2155		Uncharacterized protein conserved in bacteria (DUF2155)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4765)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.30	21.30	22.40	22.50	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.12	0.72	-3.88	47	322	2009-01-15 18:05:59	2007-07-30 16:06:44	4	3	319	0	107	251	923	91.50	43	52.17	CHANGED	AslpuLDKloGcsp-l-ltsGcssphGsLpVslptC..RhPs-.sPsssAFstl.........slpcpspst.......lFsGWMhASSPuLsAl-HPhYDVWVhcC	.........................................................AhhpuLDKITG+h.psh-lhlGE.o.spF..G.u.Lplss+sC........hp......R......sssE.sspssAFlpl..................Tlscphpc.........lFsGWMaAsSPuLsulEHPlYDVWlpcC...............	0	32	66	79
+9756	PF09924	DUF2156		Uncharacterized conserved protein (DUF2156)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4866)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	27.20	27.20	27.40	27.20	26.50	27.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.65	0.70	-5.60	156	2342	2012-10-02 22:59:21	2007-07-30 16:07:05	4	28	1932	2	547	1913	59	286.60	23	38.43	CHANGED	ttllppts...tpshuplshhpcpphhh.s....ssp....uhlha....thpspshlshusPlG...s.....pphsphlppahphuppt.uhtsshYplstchhshhpc.hG.....hphh+lGp-sllslpsa.sLs..G++hpslRptlN+hc+pG..hs..hchhth.....sphhscltplucpWhpt.c..........pE+sFohuhhctthht.p..hthsl..lcs..-G................................clhAFsshh.sht....psshslDlhRtpsc.uspGhh-hlhhph...hthhptpG.......hphhshuhushtth...t................................t+hhthlh..tpphashpGLRpaKtKapPpa.ts+Ylsh	........................................................................................................t...htphs.sssh.u.thhhht..D.+th..hh..s............ssp.............uhlha......phpss..t...hl.sh.G-PlG........st..............pph.t.ps...l.ptFhphsc.ph...u..hpss.ahp.lspp...hh..h.h..pc..hG.........................hphh+lG-..Eu.ll.c.h...ps....F..sl....s.....G++.....h.p.sh.Rptls+hc.+tu.hs...hchh..p..........sph...h....p.clpp.l.u-pWhss.+..................................pEpsF..ohuh..h....c...t....t.......ht..p.....tt.h.sl......hcs.....cG..................................................................cllAFsshh...sht...................ppshol.DlhRt..p..s.....c.s...spGhh-hlhhphhth..tp..p..p..G.................hphh.shuhA.....s.htsh...........s................................t...u..................p+hhthlhph.hpphas.h.pGL+chKpKapPpa.ps+Yhs..................................................................	0	193	362	467
+9757	PF09925	DUF2157		Predicted membrane protein (DUF2157)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4872)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.40	25.40	25.70	25.60	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.11	0.71	-4.59	51	469	2009-01-15 18:05:59	2007-07-30 16:07:22	4	6	466	0	144	421	111	138.90	23	29.45	CHANGED	ltpWhcpGlls.........sssspplhthhs....t..ssttp.....hshhLhhlGulhluhGllhFlAtNWppls+hs+hullhshlhssthsuhhhhh.............................ptpthhupAhlhluull.hGuhluLlGQhYphuuc.h..phhhhWulhslshAhhhppsslhhl	........................................................t.ls..........tthtth...ht...................th.p.............hhh...hlhhlGulhlusullhhlAtNW........pthschh+lullhsl.lhs...shhsuhhh.h................................................................pt..pph....hsps.hhh.hu.uhh.hGuhlAllGQh.YphuuDs.a..phhhhW.slhhLshuhlhp.t.hhh.h...................................................................................	0	41	89	121
+9758	PF09926	DUF2158		Uncharacterized small protein (DUF2158)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5475)	Family	Members of this family of prokaryotic proteins have no known function.	22.00	22.00	22.20	22.30	21.30	21.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.85	0.72	-4.53	18	536	2009-01-15 18:05:59	2007-07-30 16:08:06	4	3	515	0	65	179	7	47.80	68	73.29	CHANGED	FplGDlVpLKoGGPcMTVo.shs........htsushhhCpWFsspu.....cpthFsE-oLt	...FhVSEEVTVKEGGPRMIVT...............GYSSGMVECRWYD...GaGV....KREAFHEsELV.....................	0	6	19	37
+9760	PF09928	DUF2160		Predicted small integral membrane protein (DUF2160)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5477)	Family	The members of this family of hypothetical prokaryotic proteins have no known function. It is thought that they are transmembrane proteins, but their function has not been inferred yet.	25.00	25.00	29.50	29.30	22.50	20.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.27	0.72	-3.89	37	244	2009-01-15 18:05:59	2007-07-30 16:08:49	4	1	231	0	96	238	242	89.80	49	93.67	CHANGED	WMAWThPoAlFFssIushLhsMTlhE.l+pP.ss.R+GhLsIpTTRGDRLFIuLLuuAaIpLuWlGlss...........sslWhuhslSllahhhlhRhs	..............WMAWThPTAlFFhsIuhhLssMTlaE.ltpP..ss.R+GhLsIsTTRGDRLFIuLLuuAaIpLuWlGlss................s.s.l..WhAhslSllahlhlhRhs...........	0	16	43	65
+9761	PF09929	DUF2161		Uncharacterized conserved protein (DUF2161)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5482)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.40	20.40	22.90	38.00	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.52	0.71	-4.18	30	134	2009-09-11 04:54:42	2007-07-30 16:09:03	4	2	129	0	48	143	23	113.40	43	50.24	CHANGED	llsVc.pcG..tVEVhsDPu.PasPRK....sp+++s+LLpEFpRRpGDPNsGGuTR.pslhTAYRQ-ALpsAsaLuttGPs+uucltctssVs.cATpIhpcNHYGWFERVp+GlYsLTstG+suL	...............hlsVp.tsu...tVEVlscPs........sh..t..P..R+.......s.+++sRLlcEapRRpGDPssGGuT.R.tslhTAYRQpALtCAstLs...tG.st+stclppt...ls.pAspILtcNhYGWF-RlpRGlYsLTssGctu.l...........	0	13	27	33
+9762	PF09930	DUF2162		Predicted transporter (DUF2162)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4827)	Family	Members of this family of bacterial proteins are thought to be membrane transporters, but their exact function has not, as yet, been elucidated.	28.40	28.40	28.90	37.90	26.10	28.30	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.59	0.70	-5.21	15	44	2009-01-15 18:05:59	2007-07-30 16:09:15	4	1	38	0	33	43	2	225.80	27	93.79	CHANGED	sssLahhGlLhullIFGlKsGlGhGFuslS.+KtlhhIsuuYhllshll...utlAsphshplhphlhshGhslHsllulhlIhsGlaTl..+cWtspG..KDs...o+pThLAlslPCPsCLuAlhhSshllusslslSshplGhhlGssFhlsl....lloshls+....thshssP.sLGshMlhlGlYFLluulllPuhlpstphphsshth.........sssshhhslllhhsLllsGalhs+tc	...........lh.hGlLhu.lhIFGlKhGLuhG...a..u.sl.o.++thhhIs....hh....Yhhhhhll.......uhlssth.s.....phhphlhphshhlallhulhllhsGlaTl.....+c..Wttps..+ss.................sppohlshhhPCPsChuAlhhShhllushlslSshplGhhl.....ullhhlhl........lhoshlh+.....thphstPh.hLGshMlhlGl.YFLluulllPshhpstph.thsshsh.........shpslhhshl..hhhsLllhGalhp+h.p.....	0	12	27	29
+9763	PF09931	DUF2163		Uncharacterized conserved protein (DUF2163)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5449)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.60	21.60	21.70	21.60	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.78	0.71	-4.47	52	337	2009-01-15 18:05:59	2007-07-30 16:10:04	4	4	307	0	94	298	50	154.50	26	56.38	CHANGED	Mpsh.sssLtsHL.psusTTlscsWtlsRpDGsshGFTDHDpsLsh-GlsacAsoGh........ousslppssGLulDssEsh.....GuLss.....sslsEsDltuGpaDGApVcsaLVNW...s-s.......st+hlhapGslGElpRus..uuFpAELRGLsc.tLspshGR.lappsCsAsL...GDucCtlD	...................................th.thl.ts.t.h.s......shshsahlp..p.t.sGhshuFT-aDpsL.s.h..........s.......u...hh....aps.ss.Gh.........ssuthppssulus...sshclp.....Gshss............stlp..c..tclttGhaDu.Apl...c...ha..hV.s.a......scs..........stphl.lhpGpl.uclpp.ss....s.thph-l+ulsp..tLspstsR.ha.pptCsAsL...GDtpCtls...............................	0	21	61	73
+9764	PF09932	DUF2164		Uncharacterized conserved protein (DUF2164)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5460)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.50	21.50	22.40	21.60	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.24	0.72	-4.18	47	470	2009-01-15 18:05:59	2007-07-30 16:10:22	4	1	443	0	102	324	16	74.70	32	88.77	CHANGED	Iclsp-p+pphlspIpcYFpcEh-p-lGshpAchLLDFhscElGPhaYNpultDApthlpc+hpslpp-la....tlE......K.	...............Iclsp-p+pchlsplpcaht--hp.ElGpFpAchLl-FhhcclGPhhYNpultDApphlpc+hpslpp-la.lEp................	0	23	53	79
+9765	PF09933	DUF2165		Predicted small integral membrane protein (DUF2165)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5472)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.80	20.80	21.50	21.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.85	0.71	-4.51	25	244	2009-01-15 18:05:59	2007-07-30 16:10:43	4	1	207	0	58	154	29	137.60	37	94.20	CHANGED	h.hlRluKslhlhulAhFusLVuasNlTDYsoNasF.VpHVLsMDTs...FPss..sltaRAIssPhlapsuYhhIIshEslsulLChhGuhpLh+sh.psssssFppAKshAlhGlsluhLlWhsGFhsVGGEWFsMWtScpWN..G.puAFRFhhhlllVLIals.s-	........h.RhuKhlhshslAhasslVshsN.lsDasoNatF.VpHVhsMDoh....a.ss....slhhRAIsoP.......hlpphuYhhIIhhEshsulhhhhGuhthhtsh.t.sstsFppuKhhshhuhshshlhW.hsFhslGuEWFsMW.Sp.WN..G..sAhRhhhhhhhsLlals............	1	18	38	48
+9767	PF09935	DUF2167		Protein of unknown function (DUF2167)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4714)	Family	This domain, found in various hypothetical membrane-anchored prokaryotic proteins, has no known function.	25.00	25.00	27.90	29.80	22.00	20.10	hmmbuild  --amino -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.45	0.70	-5.54	15	227	2009-01-15 18:05:59	2007-07-30 16:11:22	4	3	219	0	39	156	51	235.70	49	77.40	CHANGED	ulp.tsGsIsLstcpAsLsLPsuahaLsssDsp+lL.-taGNPPsssp..LGhlhPss....sspsWhVllpY-ssGYVoD-DAscIDhs-LLpsM+puscEsNcpRccpGhsslcllGWAptPpYDsso++LhWAtcL+spuu......ppolNYslRVLGRcGVlsLNhVAuhspLsplcpphpplLuhscFscGpRYADFssssDKVApYGLAALVuGs....lAuKhGLaAhlusFLtKFhKllllullulhu	................................sA.ssGPocIsLG.DcATLNLPcGFsalPAc-Auha...M..+ph..G....NhsD--h.hhGLVh.c-.......hshalslEYDDSGYVKDDDAKsWDADELhcsL+cGTcEuNK-Rht+Gl-sIEllGWlEKPsYDAssHRLIWSss.lpDhGsst...s-puVNYNTYlLGREGYhSLNLV...TDcuslD.c-h..PhA.c.clLoul+FNsGpRYADFNcSTDKIAEYG....LAALIGGl..............AAKKlGLLAhlGlhL....lKFWKVsAlGVlAlGA...................................	0	6	15	29
+9768	PF09936	Methyltrn_RNA_4	DUF2168;	SAM-dependent RNA methyltransferase	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4752)	Family	This family has a Rossmanoid fold, with a deep trefoil knot in its C-terminal region. It has structural similarity to RNA methyltransferases, and is likely to function as an S-adenosyl-L-methionine (SAM)-dependent RNA 2'-O methyltransferase [1].	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.22	0.71	-4.79	28	174	2012-10-01 22:53:19	2007-07-30 16:11:38	4	2	169	1	76	201	25	181.90	45	76.98	CHANGED	hsslhlALlHYPVhsKctclluTAlTNLDlHDIARouRTYGlppYYlVTPlpsQppLlc+llsaWpcGaGupYNPsRpEALplV+lssoL--sl--lpphpGpcPhllsTuA+.h.tsssloappl+chl..pscpPhLLLFGTGWGLspElh-psD.hlLEPIcGt..ucYNHLSVRuAsAIILDRLhGc	..................................................t.tplYluLVHYPVhNKptcllsTulTNhDlHDIuRsu+TYslptYalVsPlcuQ+cLsp+IlsaWppGhG..upYNPcRp-Ahphlclssol-sslccIcc.tcGp+Phl..l.sTuAR.....t........hsso.....loappl+chl..ps-cPhLlLFGT.G.WGLscElhptsD.alLE..PIpG.t..ucYNHLSVRuAsAIILDRLhG......	0	44	67	75
+9769	PF09937	DUF2169		Uncharacterized protein conserved in bacteria (DUF2169)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5351)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	38.20	32.40	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.78	0.70	-5.33	44	398	2009-09-11 05:29:39	2007-07-30 16:11:59	4	39	234	0	153	377	32	263.10	25	49.67	CHANGED	-.pGpphlslslKuoasls.tshh........sppQtslh.u-pah.G-Puhouhh.hpsDhshhKstsDlllpGpAauPtGcsssplp..VslcVGs.....hpKtlpVhGcRhW....h..ssstsosPpPFpp..hPlsa-pAaGG..........s.....tsh.cNPlGpGa..tpppttt...thslPslEts.sp.lpsss.....tp.t.PsGFGPlshtW.sRt....phAGT.YDcpWhcs...chPhL....PpDaD.RaapsAPsDQphst...h.pGGEtlpLhslps.p...sp.lpapLPtht.hshhh........h.hsss.........hpphphplDTlhl-s-tpplhLlWR	..................................................................h...tt.hhslssthshpl...............st.t.t.lh.ss..a....sts..t.t..uhh.......hDhs..Ksts-hl.l.sGpAau.s.tsp.sspt..hpstlplss.................hp.Kt...lplhGsR.a.........................sshthstsp.Pa.p..hslsaphAaG.G..........................................sh.tNPhGhGhh.t....tt........h......................hPslp.s..pp..hptst......................tt...ssuhGslshtW..Rh.................phh....Go.aDpt.W.hpp.......phPh..h......................PtDhD.+aapsAssDQ.hsth......h..puspphpL..hshpsp...........tt.lthpLPthpshshlh.........tpst........................hpphshphcTlhl.s.....c..p..p...phhlha+............................................	0	56	94	124
+9770	PF09938	DUF2170		Uncharacterized protein conserved in bacteria (DUF2170)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3789)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	19.00	19.00	19.80	27.60	18.90	17.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-4.82	28	545	2009-01-15 18:05:59	2007-07-30 16:12:18	4	1	536	0	65	200	8	131.50	57	94.39	CHANGED	hs.WslpsLtsuLsspsphpstphsh.llp..Gs-ssLplshp-hs-LPlaluloucQ.IlspuhLasss-Vp-..tsthN-tlL+sp.phhPLSohGltth.csc-hYshFGALSssSolsslltEltTLA-Nslcss-shpsahp	.....................M..sWsPhsLAsALpslsE...pph-...ls..NsEuuLIIKMNDYGDL.IslLFTScQ.hlIETaICPVsoIss..ssEFNpFLLRNQ.KhhPLSSVGIopV.pQEEYYllFGALSLpSSLcDIlLEIToLVDNALDlAEITc-YS.p.......	1	12	26	44
+9771	PF09939	DUF2171		Uncharacterized protein conserved in bacteria (DUF2171)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3798)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	25.10	26.10	23.70	24.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.20	0.72	-3.97	17	134	2012-10-02 14:14:57	2007-07-30 16:12:29	4	2	117	0	59	143	4	66.70	44	70.39	CHANGED	pI+EHh-VluuDGsHVGTVDHl-G.scIKLTKpDts.........tsGcHHaIPhuWVspV-ss.+V+Lstsu-pshp	...pI+-Hh-Vluu-Gs+VGTVDHl....-.G.spIKLTKsD...............sGpHHhIPhuaVscV-ss.pVhLstsucpsh.p....	0	13	33	48
+9772	PF09940	DUF2172		Domain of unknown function (DUF2172)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4310)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. An aminopeptidase domain is conserved within the family, but its relevance has not been established yet.	19.70	19.70	19.80	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.26	0.70	-6.09	18	203	2012-10-02 19:46:12	2007-07-30 16:12:41	4	4	195	1	42	243	564	367.60	46	85.76	CHANGED	LplHEVPSGTpVFDWTVPpEWNl+-AaltsssGc+llDFtcsNLHlluYStPVctploLcELpsHLaSLP-pPDhIPYhTSYYpcpWGFCLsapphpsLp-GcYcVhIDSsl.ssGsLoYGEhllPG..-occElLlSoalCHPSMANspLSGssVhshLAchLtspspR.YoYRhlFlPETIGSIsaLSRN.-clcc.lctGhVLoClGDcp.saoahtSRpG....sshhDRlutHVLpcps.psachhsFhs.hGsDERQaCSPGhDLPVsslhRohYGpYPEYHTStDsLchlsPcuLtsuashlpcslplLEsNpsYh.s.sshGEPQLGKRGLYsslusppph.t.pths.........hL.lLshuDGppoLLDIAEphshsFhcltshsctLhcsuLlc	...............................................................................LchHpl.oGTplaDWhVPpEWsl+-AaIhs.sp.Gc+IsDFtcpNL.HllsYS.slctchsL-ELpsHLaol.-.PDhIPYh..T..SY..Yp.cpWGFClsHsphp...tL....c......c......G..c..Yc..V..hIDuch..csGs..LsY.uEall.PG.........poccElLlSsal..CH.....P....S.h........AN...spLSG.s..lshhLA........+hLh.....u...h......cp...R......Y......oYRF..l.h...........h....P....t....T......I...GuI..saLu..+.........ph...-.pL.c.....+.............V+tGhV.LSClG....Dst.......sh...o.....h.h..+.S.++s......s.s....D.+lhhHs..L.pp.p..........p.sa.c...hasFhs....h....G...DERQas....u.PGhNLslsslpRoh.Yu..cY..spY.HTStDsL.s.FIo.cuLts.uhph..htc.h.I...hL.EhN.tsah.N.o.hs..EPpLG+RGLYto.....lus...ps.....ch........h.........hh.hLshsDGppsllDIAp....hhsh.hhphtphh-+ltthGLl...................................................................................................................................................................................	0	15	27	35
+9773	PF09941	DUF2173		Uncharacterized conserved protein (DUF2173)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4831)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	24.20	24.20	24.90	26.10	23.60	24.10	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.26	0.72	-4.11	11	47	2009-01-15 18:05:59	2007-07-30 16:12:56	4	1	30	0	31	40	0	106.30	40	93.38	CHANGED	.pLccLMplsGVhAAscFosDGcLh..EacG..plscchAchsAphCuANshhspMpAcuaophoGpsGWpPhpGWslsGs-auVClsGshuVFVcpscssasclhcsLpps	..t.cLc+LMpLpGslAAGcaosDG+Ll..cYpG.....shsc-hA-MlApMsAANshMuphpA-uaothS......Ghc.WsPhhGWAVsuu-YsVClhGNhGVFVchscADFNplF+sLtc.....	0	11	23	27
+9775	PF09943	DUF2175		Uncharacterized protein conserved in archaea (DUF2175)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4847)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	25.50	29.00	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.43	0.72	-3.96	10	32	2009-01-15 18:05:59	2007-07-30 16:13:27	4	1	32	0	18	31	5	97.60	40	92.31	CHANGED	p+WKCslCGcsIhpGpLFTFhSc.GsVHa-ChccctspKhpt-s..plssL.pL--hlpcslVhtccLsplu-sEElKcllcpscKplE+tAAcLT+clpch	..pKW+CslCspsIh.spLFTFhpp.GslHasCLccchhppsph-s...thhL.pL--.L+phllhtpcLppltp.EEsK+hlcphcKshE+pAuhLTphlpc.h.....	0	4	8	13
+9777	PF09945	DUF2177		Predicted membrane protein (DUF2177)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4852)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.10	20.10	20.10	23.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.68	0.71	-4.15	50	240	2009-09-11 01:55:54	2007-07-30 16:14:14	4	1	231	0	82	203	342	125.50	36	93.84	CHANGED	Mpph.llhYluohllFlsLDhlWLuhlucshYcsplGslhtcp.....hRhsPAllFYLlYluGllhFslhPultsushtpul.lhGALlGhhsYuTY-LTNhAsL+sWshphsllDlsWGshlTusuuhhGhhl	............phlhhalsohllFLllDhlWLshhucph...YpptlGsLhtst.....schsP.AllFYllYlsGlshFslhPulpp.........s.sh.st.......sl.lhGALhGllsYuTYDLTNhATL+sWshphsllDlsWGohloulsushuhh..............	3	26	46	61
+9778	PF09946	DUF2178		Predicted membrane protein (DUF2178)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4854)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	22.50	22.50	22.50	23.20	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.38	0.72	-4.32	12	56	2009-01-15 18:05:59	2007-07-30 16:14:43	4	1	44	0	46	58	1	111.00	20	81.38	CHANGED	ppaphllhhlshhhGul......luaAhssGsshlAlhsVhhGlhhhhhl+p+l-s...VlEDERhh+luEKAShhTlplhsl...shALuGshlh....shp..hsthsphuhhlsaushhlllLY	..............................hhhhhllslh..hshl......huausps.....ups...hlu.hhshhhuhhlh....hhh...cp.plcc.......l...l.EDERsh+IsEKAuphTlp...lhhl...shul.tslhhh....hht....t...hh.h.h.h............................................................	0	6	25	39
+9779	PF09947	DUF2180		Uncharacterized protein conserved in archaea (DUF2180)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4855)	Family	This domain, found in various hypothetical archaeal proteins, has no known function. A few of the family members contain a zinc finger domain.	20.90	20.90	20.90	21.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.54	0.72	-4.22	13	46	2012-10-03 10:42:43	2007-07-30 16:15:47	4	1	38	0	34	45	0	67.50	43	89.15	CHANGED	MKCYhCAcEGKDT-AVuICIVCGMGlCh-HllR-ElshWcGGYPaPsc........KlKcsLPRILCh.CasAhpt	...MKCY.CstpGK.Do.-AVAlCIVCGhGlCh-Hsl.+..E-l.shhp.G.uYPhstp.........+hpcsl..PRlLC..ChsAhh.t.......................	0	8	25	28
+9780	PF09948	DUF2182		Predicted metal-binding integral membrane protein (DUF2182)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5486)	Family	This domain, found in various hypothetical bacterial membrane proteins having predicted metal-binding properties, has no known function.	25.90	25.90	27.50	53.40	24.10	25.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.62	0.71	-4.39	51	254	2009-01-15 18:05:59	2007-07-30 16:16:03	4	2	201	0	94	263	221	188.40	34	70.97	CHANGED	hhsMWslMhsAMMLPoss...PhlhtYpclhttt......spstshhshhssGYlhlWhuaullAtslphsLtthuhhsshhs.sts..hluuslLlsAGhYQFoslKptCLspCRsPhsahhpc..WRsG...htuuh+hGl+pGhaClGCCWuLMslhFsuGlMsLhWMuhlolh.......hslEKl....sshGctls....+slGslLlshuhhhl	......hsMWhlMhlAMMLPoss.Phlhtapclhttt......sppshth.shhssGYLssWsuFullAtshphsLpthuhhs.shhs.ss...hluuslL.hlAGhYQaoPlKptCLspCRsPhsa.l..h..pp...a..R.su...htsuhphGl+HGhaClGCCWuLMslhFssG.sM.slhWMuslshh.......hhhEKh....hPt.Gc.h.lu....+slG..ssLlshushl.h.................	0	20	51	70
+9781	PF09949	DUF2183		Uncharacterized conserved protein (DUF2183)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4850)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.50	26.50	26.80	26.50	26.00	26.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.23	0.72	-4.07	76	563	2009-01-15 18:05:59	2007-07-30 16:16:46	4	9	433	0	307	521	33	99.20	37	20.65	CHANGED	shaYVSsSP.WNLashLppFlpppthPtGs.lhL+ca....ssshpphhpsspt...+KhpplcclhppaPphcFlLlGDoGpcD.s-lYsclscpaPspltul..aIRpl	...............................................haYlSsoP.WNlashLppFlpp....psa..PtGs.lhL+-a.........sss.pshhpsusp......+Kpstlcclh.psFPch+alLlGDsGQpD..clYs-.hscpa.Ps+ltAI..hIRp.........................	0	99	187	265
+9782	PF09950	DUF2184		Uncharacterized protein conserved in bacteria (DUF2184)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4834)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.80	26.80	26.90	27.10	26.50	26.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.27	0.70	-5.32	26	275	2012-10-03 06:22:39	2007-07-30 16:17:03	4	3	246	0	39	242	28	236.10	25	74.81	CHANGED	sGtA..phlu.stusDlPtl-lshscppsslthhuhuasaolpELcsApth.GtsLsspKspusppshppplsplsahG.....-sspGhsGLlNp.sulssssssss.......W......tspTs-pllsDlsphlsslhstosh..sthssplLLPsspathLupphhsssssholLcalpcsNh.........hs..tG.sLsIpsltt.LcssGsuGs.......sRhlsYcpssphlphtlPhshphLPs.Q.pslchcVPhht+hGGlplhhPtsltYhDGI	.......................................h...t..phlu.ptuss.lstlslshscptsslthhuhthsaol.ELpt..Apts.Gps.ls..spKhc..uhphthphc.schsahG.......-ssh.s...lpGLlNt.sslssssssts...............W.......sssTs-...cIhss...lsp.hlsssh.tt.osh....sh.........s.Ps....s.LhlPsppa.shLssphhs...s..s...s.s.polLpalppNsh.............t..sLs.Ip.....s.......lh....L.......c......st.G..susp.........cp.h.lsY.........spc.........chlph...l.hshpt....lss..Qhc..s.lh..hsshht+hGuVt.hh.tsh.hhDGl...................................................................................	0	4	23	30
+9783	PF09951	DUF2185		Protein of unknown function (DUF2185)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4859)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.30	26.60	23.60	24.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.93	0.72	-4.19	11	257	2009-01-15 18:05:59	2007-07-30 16:17:12	4	19	221	0	31	197	7	88.00	33	31.24	CHANGED	sIVSNsVh.-+R.hsFha+EssphEsDSGWRhFSG.EoD-YssDP.cNFpIlSlusIhplDsolhtlLppP.ssAaEhs--Gs.F.cltDa	.....CIsosplh...ps.ptlsahaRE.pP..s..t....p..s...DSGWRhhSGsEoD-YhscP....cNhsl....lslsslhph-Psllsl.ls.t.P..Go....saph..scpGt.a..l.........................	0	17	22	27
+9784	PF09952	DUF2186		Uncharacterized protein conserved in bacteria (DUF2186)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4861)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.10	20.10	20.40	22.00	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.77	0.71	-3.94	11	178	2009-01-15 18:05:59	2007-07-30 16:17:31	4	3	169	0	45	154	10	143.50	27	41.90	CHANGED	RLh.ctccLL-pWAtsYPs+Lps+hphhcFsu..st.sWhpphsltshsA......hhuGEsAAscLss.l+PsshslY....stpshsscLlhptRL+c.......sspGs.Vplhcs.....FWs.p..................shtchslssPhllYADLluoGDsRshEsAphIh...-chls	......................................Lh.cscpLL-tWsts..YsstL.ttp..h..phht...h...su.......p.......p..hh....t.h..s..ls..s...t...............thuGEsAus.h.st..hp...Pts.h.hlY....sssshsscLlhpt+h.+.........sscGs...lhlhch......FWps...................ssp.p.sslsPshLlYADLLsos-sRshEsAchl+..-....t.............................................	1	18	30	37
+9785	PF09953	DUF2187		Uncharacterized protein conserved in bacteria (DUF2187)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4873)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	21.60	21.60	22.00	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.74	0.72	-4.24	7	524	2009-01-15 18:05:59	2007-07-30 16:17:44	4	1	440	0	39	139	2	57.60	57	85.89	CHANGED	MphAcVGsIIEFKsGLpGIVEKVNENSVIVDLThMENa+-L-l-p+TVVNHKNYKII	..................MplAcVGsIl......E.F....h.s....G...l..pG+V.EKlN.-NSVIVDlTIM-NFs-...L...D..l...-KTVlNHKpYKIl.......................	0	5	16	26
+9786	PF09954	DUF2188		Uncharacterized protein conserved in bacteria (DUF2188)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4876) & Jackhmmer:B5ZC26	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.02	0.72	-4.05	101	747	2009-01-15 18:05:59	2007-07-30 16:18:01	4	2	643	0	192	487	10	59.90	24	57.15	CHANGED	haVs..P.tpsst.......WtV+tp....Gss+s.sphasTpp-AlptA+phA.cp....p.su-lhIHsp.D.GpIpccpoa	..................pptt........Wtl+st....sspps.otphss+p-AlchApphu.+p.............p.ssplhl+pp.D..spht...............................	1	56	107	147
+9787	PF09955	DUF2189		Predicted integral membrane protein (DUF2189)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5473)	Family	Members of this family are found in various hypothetical prokaryotic proteins, as well as putative cytochrome c oxidases. Their exact function has not, as yet, been established.	22.80	22.80	22.80	22.80	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.81	0.71	-4.20	69	418	2009-01-15 18:05:59	2007-07-30 16:18:23	4	1	318	0	155	393	69	127.20	27	45.87	CHANGED	llhshsuGFhLl.GPh..hAlGLY-lSRRhEp...Gcsssh..tpshts.....hstshsphhh........huhlLhllhlhWhhsAthlaAlhh.s.ss.shss.hsshht.lhhsspGhthlhlGsslGulhAsllauloVl...........ohPllL.D	................................................hlhshssGFhLl.GPh...hAlGL.Y-hS+chEp.......Gptssh..tpshps.....hs.shsphhs..........huhlL.hlhhlhWhhhuthlaAhhh.u...sh.shss....hsshht.shhsspshthlllusllGslhAhlsauloVl...........ohPhhlD..........................	0	36	96	124
+9788	PF09956	DUF2190		Uncharacterized conserved protein (DUF2190)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5471)	Family	This domain, found in various hypothetical prokaryotic proteins, as well as in some putative RecA/RadA recombinases, has no known function.	20.80	20.80	21.50	21.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.31	0.72	-4.27	30	380	2009-01-15 18:05:59	2007-07-30 16:18:52	4	1	318	0	62	202	18	105.40	45	95.92	CHANGED	MKNYlQsGcslsls.Ass.uVsSGssVllGs..lhuVAh.sssssGpssphhspGVF.sLPKsuussh.shGstVYWDsospshTs..suouNshl....GhAhtsAussu..sossV+Ls	....................................AKNF.Vp-.GcTlslV..Aus...uIpSG-hV.V.Gs.............lhAVAl.TDIstG.....EsG-...G.....h...sEG.V......F.hLPK...h...p.s..D.Dh..psGppV.........YLKsu..t..lQLss........usu.ssh.l.....GVsWtsAusuu..ppVsVKlN..........................	0	15	35	48
+9789	PF09957	DUF2191		Uncharacterized protein conserved in bacteria (DUF2191)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5450)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.40	23.40	23.60	23.40	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-8.03	0.72	-4.15	51	685	2012-10-02 18:44:02	2007-07-30 16:19:12	4	2	332	0	155	436	50	47.60	33	65.80	CHANGED	MRTslslDD...pLlpcAhclsG.lpoK+plVchAL+sLlppcp....p+...th.cL	.........RTsIclDD....cL...l..scA.hchsG..hpoK.+..s..sVchAL+p.llpttt......tc.....p....hh......................	0	43	111	140
+9790	PF09958	DUF2192		Uncharacterized protein conserved in archaea (DUF2192)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4879)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.60	20.60	20.60	22.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.44	0.70	-5.13	12	48	2009-01-15 18:05:59	2007-07-30 16:19:24	4	1	46	0	29	44	0	223.30	36	83.96	CHANGED	hs+plaRcRIcshhsLlpclLpt...thhoRpsllt.LpcsYcccsIcPhRGhu.spslY-KElAolYVVGKYGhGlhs-..t.FDclF.hEpph-EAhcll......lstphpEAhtchss.l..ts.ccspltRhLRllFTtslhGahsEptLlKsl+shp.s.hP-hpcphhsYutFYsAaKlAEsIAtGcIRs+.shcAhKhuhAlclGh..p+slPsDchIAhIAppVapVscphLs+lL	..........................................sKpla+cRIclhs-lhupllcp....psloRpsll-llcpsYcccsIcPhRGhs.ssslY-KELsolYVVGKYGLGLh..-.-...phF-+lF.hEpph--shclI........lsspspEAhcch..ss...t...sc-hlARsLRhsFTpslhuF.sE-chh+sL+slphu.hs-lccsspsau+FYsAaKlAEsIApGtlRs+.shpAhKpAlAlplGh..phshPpscYluhIAccVFpVscclLs+lL............................	0	11	17	22
+9791	PF09959	DUF2193		Uncharacterized protein conserved in archaea (DUF2193)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4883)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	403.50	403.00	22.30	17.80	hmmbuild  -o /dev/null HMM SEED	499	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.74	0.70	-6.24	9	32	2009-01-15 18:05:59	2007-07-30 16:19:37	4	1	31	0	23	33	2	497.80	65	99.61	CHANGED	MpELYcKMlDEAMuAQ+ADV-slK+KRGpcFplpDAKPYVDsVpKMcssusQSpuVhsLHhsSVpuHa-lLsuLTcTVRPEDDPFVEHYQTPsILEILh-EDstFpKSl-tFlcuItKuEALIG+EulRRYGGFYGPTCVVDFALlPGSTSNVVNRILppsDIPhcHKQAILAAKSWGMNTSYGIG-hFAptlEtGsThuEAs+cEI-MlQhlYcpPlEAQAcLMDsAGppSFDsRKYMpsY+p+McssV+AAhD-GVHYGNIlTVPAYCVGDlAHHIuQSTFNMCKDDVVMAlIEAsTsVMEoTLpsAlspFKsEYslLoLATGuSAsAsEaILELDGFNAhMlVDLLTKRFHNYV.haPTRGAAAELHNsDFMDMIYRGW+hlDKAcRspsutpt.l.PhVuGasVDLSPIacNEVlMNPQRYAYPACAITVRFSALMRLADYPCLLTSEPVTAThMTNIIALHKEssuuPARsCKsCAsAsLlDaRHpYCQWKEAV	..MpElYcKMlcEAMAAQpADVpsIKcKRGpcFKIcDAKsYVDsVsKMcslssQupuVlcLHhcSVpuHa-lLsuLTcTVRPEDDPFVEHYQTPsILEILY-EDspF+KSl-KFIcsIs+uEALIG+EslRRYGGFYGPTCVVDFALIPGSTSNVVNcIL+psDIPtpHKQAILAuKSWGMNTSYGlG-sFApslEsGtThuEAlccEIchlphIY-pPl-AQA+LMDst..G....HpSFDVRKYMspYKK+McssVpAAh-ssVHYGNIVTVPAYCVGDIAHHIuQSTaNMCKDDVlMulIEAsosVM-sTL+ssl..sp..FKsEY-lLoLATGSoAsAsEYILELDGFNAsMVVDLLTKRFHNYVQLYP.TRGAAAELHNsDFMDMIYRGW+hlDKARRs+sGsts.ltPcVuuacVDLsPIccNEVlMNPQRYAYPACAITVRFSALMRLADYPCLLTSEPVTAThMTNIIALHKEssuuPARsCKsCAoAsLlDFRHpYCQW+EAV................	0	8	18	20
+9792	PF09960	DUF2194		Uncharacterized protein conserved in bacteria (DUF2194)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4878)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.00	26.00	26.70	26.80	24.40	25.90	hmmbuild  -o /dev/null HMM SEED	585	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-13.07	0.70	-6.47	8	111	2009-01-15 18:05:59	2007-07-30 16:19:48	4	3	107	0	24	106	3	535.50	29	88.40	CHANGED	lhllLhh.hlu...........................................................................................................IshhhsKhGlpYshss+p.h..t.........s.sssslspsh-p....plh.................................LaDsNs-supcl.......................c..........pphcphLcYh+hphchls.u...pcshPSl.cY+sllIhhs-lstls-..pslhsalEsGGsllhAsshc+ssthssI...hGlp..p.-hsclcslhlspDlh..lGuscs.thpt.F.cpulslsLsscsplphlossc.pTPllWppchGpGphlhhNhsllpKp.lRGlassuhuhhsssslhPlINutshYlDDFPuPlPuG-tc.lp+-a.shoss-FYpKlWWPDlpKLuEcYsIKYTGlhIpsYpssTsss.shhctpspscalhaGppLL.ssuGElGlHGYNH.PLs.cs.s.hcc..tYh.Wts+EshtcuLcpLp+Flps.LhsshphssYVPPSNllscpGhcsLhcshPpIKoIuSsYhssc.ptsY.QEFplt-..cGhlclPRhTSG.hhsscphhhsshssLs.hGVhsHFlHPDDlLDtDRu.uphuWschhKsLcshlchl+cpaPaLRshTuSEsusulpcYtshcsphphscsulclslpshccpsthhlRts+sp..KlpGGp.....lh+h..susLYl	...........................................................................h..............................................................................................................................hhp..s......t...t.....................tt..th.h..tth..tt.phh...........................................lhcsssp...upph.................................hpphcphhc.h+hthp.hs.s...pt.hsshtsYpslllhhsph.ptlsp..h.pl...hpaVppGGsllh.....utp.pp.ss.h...ssl..........hGlpptt..t.t.p.s.pslhhppshh...Ghsp.h..t...s..t...h.cou......h...p.......l...............sLs......pssp.lhh..ho........scs....hP.llWppshGpG+llhhNs.s.h.hpcp.sRGlhssshuhhssshhhPhlNupshalDDFPuPlPpspsc.lpc-Y.phosp-FYpplWWsDhhclucchsl+YTGhhI..tsYpspsps....p.hp..........t..p.s..h.........pph.hhaGppLl....ppGGElGhHGYNHQPLhhts.phhtth..sYhsWtsppsMttulppLhp..ahpp.hhPphphpsYVPPSNllsppGhpsLtcshPplcsIuShYhsspp....s..a.QEFthsp..c..s..lhphPRhoSG.hhhsc.p.hthhstlshhhlhoHFlHPDDl.........lD.............t-........Ru.tphsWpp.......Lhcshcphhp.lppphP.l+shTtSEhssthppatshphphphp-stlplt..htshhptshhhlRhpps.....plpsGp.....hpcl....ssplY....................................................	0	11	14	20
+9793	PF09961	DUF2195		Uncharacterized protein conserved in bacteria (DUF2195)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4893)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	73.70	73.60	22.40	16.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.52	0.71	-4.32	6	124	2009-01-15 18:05:59	2007-07-30 16:19:56	4	2	121	0	8	50	0	122.80	52	92.21	CHANGED	sllLuusshs.uPhhAsAus.h.l-NsLuAClch+sut.....psucshltl.hslph++ShG-CGChSALlpYpslstpt.....susphsLQcGlhsstpsssR...TLsLAsDssLst-pplslplGCsssc	....l.hhphsuGh.lslhA.sGp.l.IcNsLAtCVDh+st+.....pphsNllhlpsshpL+KshGtCGChSALspYsS.lsp......RtSthhLQpGlhsLtKpss+...oLsLAs-stLV+DtpltlpluCs.P..	0	2	6	8
+9794	PF09962	DUF2196		Uncharacterized conserved protein (DUF2196)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4895)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.20	25.00	24.00	22.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.88	0.72	-4.18	39	362	2009-01-15 18:05:59	2007-07-30 16:20:21	4	3	326	0	139	286	19	60.90	60	66.71	CHANGED	hsGppRssIp.GhpVsI.VLKpDQRoGpLTcGlVp-ILTpSssHPHGIKVRLcsGpVGRVpcI	.................MsGppRusIpsGhcVsI..VLKp..DQRT....G..+....LTcGlVKDILTNSssHPHGIKVRLp..D.G.Q..VGRVQpI......	0	47	101	120
+9795	PF09963	DUF2197		Uncharacterized protein conserved in bacteria (DUF2197)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4896)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.20	22.20	22.60	22.20	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.96	0.72	-4.01	13	385	2009-01-15 18:05:59	2007-07-30 16:20:30	4	1	354	0	37	121	0	53.10	48	86.80	CHANGED	M+VKCllCDpl-pID-cohhAKRLRNRPIHTYMCc-Cc-RIccpTppRhsTGpFph	...hpVpClICDpKshlD-coscuKRL+N.p.PI+TaMCc-CcpRlsp.p.c...utpa................	0	13	22	31
+9796	PF09964	DUF2198		Uncharacterized protein conserved in bacteria (DUF2198)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4897)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	30.20	30.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.41	0.72	-4.22	9	297	2009-01-15 18:05:59	2007-07-30 16:20:41	4	1	297	0	21	75	0	72.70	63	95.13	CHANGED	hphlhALhFPslLVlLFoRVTYN+aVGllLTsALlsAShhKGYTcohalIslDlsSLlAGaLahsphctct+pc	..IWYhSAAFFPClLVVLFSVITRSKWVGTlLTLILIGASlYKtYFHNEWIIFIDVVSLLAGYLIIDQLEFHK+Qc....	0	5	10	17
+9797	PF09965	DUF2199		Uncharacterized protein conserved in bacteria (DUF2199)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4899)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	27.30	29.80	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-11.08	0.71	-4.36	6	159	2009-01-15 18:05:59	2007-07-30 16:20:54	4	2	152	0	24	125	3	142.40	40	83.45	CHANGED	YpCssCGEhHEs.P.SauFcAPssYhplsEEERps.pschuDDLChIp......DGpcaF.IRslLEIPIhGp-EsahWGVWVSlSEsSFc+Yh-oF..spssps.saFGWLsNhlPhY.s.Thu......LcscVHhpsDGpRPhlhLacus.Hs...LshD.ccGI	...................................CtpCst.H......tthP..uhGhpAP......Y...p....lstcE.R.s.....ps..c.....hs.....uDhCll.......DtpchF.IRusL.IPII.sp.....cE...sh.aGVWVSlSccSFsch...ppa...c..c..p..t..p..s..s..sYF.GhLssclPsY.s..Ths......L+s..sVphpssGpRPhlpLc.p.o.s.HP...Lsh-.hpGI.........	0	9	18	21
+9798	PF09966	DUF2200		Uncharacterized protein conserved in bacteria (DUF2200)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4898)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.00	22.00	22.90	23.20	20.20	19.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.39	0.72	-4.20	37	512	2009-01-15 18:05:59	2007-07-30 16:21:09	4	1	506	1	101	279	74	109.20	58	93.45	CHANGED	RIasMoFASVYPhYlsKsEKKGRT+pEVDplIpWLTGYspppLpptlscpssFETFFspAPplNPstsLIpGVICGhRVEEIEDP..LMppIRYLDKLlDELAKGKtMEKILR	........+lYsMpFAuVYshhIsKsERKGRp..p-EVcpllpWLTGY-..ssltt.pLcccVTatsFFtpAPhhsPppthITGhICGVRlEEI-DP..LMQcIRaLDKLlDELAKGKshpplLR............	1	45	82	95
+9799	PF09967	DUF2201		VWA-like domain (DUF2201)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4900)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. However, it is clearly related to the VWA domain.	26.40	26.40	26.40	26.50	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-4.11	16	512	2012-10-10 16:07:06	2007-07-30 16:21:21	4	6	465	0	176	533	365	126.10	24	28.68	CHANGED	lslslDTSGSIssttLspFtuElsuIt++h.tAp.lpllhsDsplpssphhcs..hct.lsclphsGGG.GTDasPll-tAsctcPsssVl..LTD.LpG.PschtP.thPVlWslst.psssss...P.FG+hlp......Ls	......hlslDoSGSh.......s...c..p......l......p........p..........hl..sElh....s....lhpp........h.....pt.....c.....l....pll.p.s.Ds.plpss.thlps...............t....ht.p.....h..p.....l...t..GuG.G.Tca....pssFc...a..s....p.....c....t......p...........p.....s.s..l.....l.....lhhTD..u......ps.......t..htP.....th.....s..ha.lh.t...........t...................P..au......h.........................................	0	70	116	150
+9800	PF09968	DUF2202		Uncharacterized protein domain (DUF2202)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4902)	Domain	This domain, found in various hypothetical archaeal proteins, has no known function.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.98	0.71	-4.57	12	134	2012-10-01 21:25:29	2007-07-30 16:21:30	4	4	106	5	72	171	17	151.70	38	65.03	CHANGED	EtcsLlaMREEEKLARDVYlsLYchWt....lslFhNIup.SEppHhctVphLLc+Ysl.............pDPlhs-phGhFss.clQpLYNpLlpcGSpSh.DALpVGAhIE-LDIhDL.cchhpcosNp...DIphVYpNLhpGScNHhRuFsRslcphGhsYpPpYlSppcappIlpus	..........................EhcsLlaMhEEEKLARD..VYhpLYcpas....l.l.FtNIup.SEppHh.sA.lttL...lc+..Ysl..............s.DP..ss..s..p...t.h.G..hFsssc....lQpLYs..p....Llpp..Gp..p..S..h.h-ALpVGshIE-lDItDL.pchl.ppsssp..............DIphVYpsLhpGS.c.N.HLRAFhpt.L.p.p.h..G..h.sYpPphlsptthptllp..s.........................	0	23	45	65
+9801	PF09969	DUF2203		Uncharacterized conserved protein (DUF2203)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4911)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.80	20.80	21.10	25.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.89	0.71	-3.89	23	128	2009-01-15 18:05:59	2007-07-30 16:21:42	4	1	124	0	57	116	64	118.60	30	87.62	CHANGED	phFolcEApcLLPhlcchhpph....tct+pplcch.......c...............htthcpph..cphtpplcttlcc....lpphGl.lKsl-.GLVDFPuhhss.c.laLCWKhGEs-ltaWHth--GFtGR+sIp	................................+hFTlcEApplLPhlcthlppl....tphppclpph.t.th...tt.tt.....................h.thctch..pphttplcphlpc....lpphGlhlKs..lc.GLlDFPuhhss..c.laLCW+hGEscltaaHth-pGFsGR+Pl...........	0	30	41	52
+9802	PF09970	DUF2204		Nucleotidyl transferase of unknown function (DUF2204)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4914)	Domain	This domain, found in various hypothetical archaeal proteins, has no known function. However, this family was identified as belonging to the nucleotidyltransferase superfamily [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.78	0.71	-4.81	15	161	2012-10-02 22:47:23	2007-07-30 16:21:59	4	2	147	0	66	166	23	151.70	25	59.21	CHANGED	thpsLttlhppLp-+Gl..caVlIGusVlsLuhsp+hsssDVDLFlhshSsll-p-hac-lAcEpsW-hGposhGTsthlshls.uEplpVDh.aENIhDlalPtElLscucclsIsGlcl+sIslE-hlVLKA+tupcEsp-hlcclu...................chlh-..tplplshchl+chlphaPE.-scsIhcRL+p	..................t..pshttlhtpLp..cp..Gl......phhllGGs.shh.l.s......a...sp.c...hs.TcDlDh.....hh..t..s.s..us..h.....l.-t.....l...ccl.A.p..chuW...s..h...shh..s....t...s.....s.....t.hl......h......hs.t-sh..l......h...l.t......s..l.h...hs..t.phl.thp.....ht.h..t...uhc....shEDhh.lhhsphthpps....t...hc.lh....................hh.t.................................s....................................................	0	26	44	54
+9803	PF09971	DUF2206		Predicted membrane protein (DUF2206)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4906)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	33.10	33.10	35.60	35.10	21.20	32.20	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.50	0.70	-5.64	9	29	2009-01-15 18:05:59	2007-07-30 16:22:19	4	3	23	0	23	30	1	355.10	19	51.06	CHANGED	tp+tlLhllFhhullhSHYGsAYlhhhhlhhusLhhhlhthh..................p.ppt+hshpLlhlahllhhhW...YshlusuuhFpolssIhtplh......pol...hpp.LsPpsopGhtll.ss.sshhttLhKllplhs.hhIslGhltslhchhtpppp......lpYluhuhhhhhlLlAulhlPaFu.shNssRLaplohlhlAPahlIGh.shhchIsphhp+hh......sh+s.h....thh.ohFlllhhLhs.oGal.plhpspPhShulspts..............cshh.sp-VhuuKWluphpsps..lplhs-hhsshhhhh...............sYuslspphlssspph..................pssYlaLshhNlhpphhhlp.......hh.tthhhhN...hssshphltppNcIYDNtGStIYh	.....................h.p+tlLhllFhhullhSHYuhuYlhhhhlhhshlhhhlht.h.h.........................p.pp.phshshlhlahshhhsW...Yhhlusushhts...lh...plhsp.hh........psl...h.p.hs.psspG...htlh....ht..shhthlhhhlphhh...hhlhlGhhthlhphhhtc.p...................hpY.lhhuhh.hllLlsslh..lPaa.u.shsssRLaplohlhLAPahllGhhthhphl.s+hhpthh..........t..h..............................phh.slalslhhLhs.oGhl.t.lhp.s.sho.hulspss...............tshh.s.spEltuspWlsp.psps............lhsshhph.hh.h....................a..ush...sht.htttpt..p................psuYlalsphNlppthhh.........hhstthhhhp....hsh.phlpspspIYsNusSplY......................................................................................	0	4	12	19
+9804	PF09972	DUF2207		Predicted membrane protein (DUF2207)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4907)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.00	23.00	23.00	23.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.79	0.70	-5.92	46	1234	2009-01-15 18:05:59	2007-07-30 16:22:39	4	3	970	0	247	980	138	434.70	18	83.34	CHANGED	sapIpphpsplplppcGshplpEplsYshcss..hcGlahshshsst...t.......hshpthslppss.......tssshplppssss..............phpltlasss.st.....sphphphpYplpssltha..pDh.uE..LpaplhGssWshslsplpsslphP......pshps..hchasasGshsspsp........tppsplthpsss.l.sssptlElchhh.Pp.....hsssstp.hptphhpph.t.tttht.p................tphhthhhslhhhlhhhh.hh.hhhah+hs+csphth.....................shhpa-hPtshsPshl.shlhptshs....................pc..ultAs.llcLhs+thlplpp................ccshhlplssps..........thsshEptllchlhspt....sspplshtpl...........................t.tpphppthppappslpcph..pptthhtthhhhpstt..............................hhhhshlhhlhuhlhh......................hh.....hhhthhhhhshlhhlhshlhhhh..........................tthhst..hotcGtphhtchcuF+paL..sDh.splphtsst..sltlW-chLsYAsALGlucc...Vt+phc	...........................................................................................tIpthpsphhlpt.-....ss....hphppplhaphppp.........hpG..hhslshhh.h.......s............sh.....htstpss.......................................hs.s.phpt.ptsh....................................................hhl.t.h..p......h..............s.h..phplpaplpshhhhh..............tDh...st................L.Wp.h...sp..s.....tl.tp.hphplphs.............ts...........ph.h.a..G..ttphp...............tp..t..t.....shp.hphps..h...tpt.....hplhhha..sp....................hsssts..t........h...t..p.h..h.............................................tthhhh.hh..s..hhh.h.l.s.hhh.............hh..h.h+p..s...p........h.......................................................................h.h.....ht.P...p..h..p..Phhh..t...h...l..h...p.ht.hp.......................pp....hht.As.llslhs+t.ltl.pt..............................................................tpthhl.ph.ptt...............h...hE....p.hlphhhttt...........p..hsthph...................................................................p.h.pphhpph..ppt.h..htph...p...................ht..t.................................................................h.hh.shh.hhlshhhh...............................................................hh..h.hh...h.....hh.h......h.hhh.l......h.hhhhh...............................................................h..h.sh....hs.ptGtphhh.hpuhpphL......p-h..sph.p.p.ttht...............shh.l.app..hLsaAhhhGhucc...h.p.h..............................................................................................	0	89	175	205
+9805	PF09973	DUF2208		Predicted membrane protein (DUF2208)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4920)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	23.60	23.60	23.60	84.10	23.20	23.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.38	0.70	-5.12	13	43	2009-01-15 18:05:59	2007-07-30 16:22:49	4	2	43	0	27	35	1	234.40	30	94.20	CHANGED	h+plLIS.l.lllaShVLohaPpaah.saILYFllahuIohshshRSh+..pshtshpEIusu+sLhE..EKcuscLhpKDcELhp.Ehpphs+uuhhshlhhhlalllhhllashl...hp....sthssslssths+FLsalshFEhhalluhh..lh+hlh.+.th.sshl..spsaKVoEKGIlsccphG...lthPhc...sschplNc-RKaVEl+.sspt.......plRLYs+-lc+L.slLpRl.KtLct	......................+hlLlStl.hllFShVLu...aa.PpY...a...h...haILYhllahuIohhhshRSt....+phpshtElspu+sLaE..EKcsscllpKDcEhhp.EhpchhKtshh.shhh.hhlhhI...lhhllasal..........................hthssshs.shhh+....FlsallhFphhaulshh...ht+h........lh..+h..pt...hshh..sp.uaKlpEKGllhscphu......lhhP.c...ssplphNc-+KaVEl+sssph.....sh+lRLYspDlc+lh-llp+l.+.lt.h.........	0	10	15	20
+9806	PF09974	DUF2209		Uncharacterized protein conserved in archaea (DUF2209)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4921)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	26.80	26.80	27.00	83.30	26.50	26.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.48	0.71	-4.05	4	22	2009-01-15 18:05:59	2007-07-30 16:23:06	4	1	22	0	19	23	0	123.00	38	95.52	CHANGED	lAVDISGRH+.cDGaY.hVsAuVulEVsAs+I.pVcpVslhsVhp+-s.sLhDIVc.lccslsplu..F-hhIVsE+G-haNpPcWlspuhhupshKYtEohuEhcAIEhAH+lShSsR+LLhcELclp	...lAlDISGRHc.pstah.hVsAuVtspluus+lc+Vcplclh.httccs.slpDllphlc-slspls..h-h.IVsE+G-FaN.PchhVpuhhs+cFKYsEoluERcAIplAHHlShSsR+LLhct.........	0	3	11	15
+9808	PF09976	TPR_21	DUF2133;	Tetratricopeptide repeat	Anantharaman V, Finn RD, Sammut SJ	anon	Manual	Family	TPR repeat	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.85	0.71	-4.25	350	1664	2012-10-11 20:01:01	2007-07-30 16:23:50	4	81	1626	0	351	1305	476	141.70	30	54.91	CHANGED	pspQssptpt..AShhYpplh.pu.h.............s...sscssp...............l.....st............u..schtscassT.YAshAuLhhAKttV-ss-hstApspLph.sls.ps.pDs.sLp.slAplRLA+l.lpppphDs...ALptL....ss....stspua.suh.hs-l+GDlLlu.pGcpppA+sAYptAl	...............................................................................................................t.phppspp.AShtYpph.h.puh..................s.tscs.sp............................l...ss...........spcht..s.c.tt.s.o.....Y.u.s..hA..uLp.l...Apth............l..-p.s.....-............hc............p.A......tspLpp...u.hs....ss...p....Dc....s.L..p......s.....l..h...pL....R..L....A.c..l...l.p.......p...p......h..D..s.......A....L..pp.L.....cs...........l.p....s....p...u...a......s....u.h....s..t..-....l...+.G-hhhu...pGcppsA+sAaptu.................................................	0	100	205	279
+9809	PF09977	Tad_C	DUF2134;	Putative Tad-like Flp pilus-assembly	COGs, Finn RD, Sammut SJ	anon	COGs (COG4655)	Family	This domain, found in various hypothetical prokaryotic proteins, is likely to be involved in Flp lius biogenesis.	21.70	21.70	22.00	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.36	0.72	-2.97	75	253	2012-10-01 21:13:59	2007-07-30 16:25:29	4	5	204	0	106	358	18	100.40	25	18.09	CHANGED	AuAtphsssss..........ss.ssAt...pssspsuh..........................ssst....shslpsGhass.....t.sstshhssss...................sssAVpVsssps.......ls.hhFsshhuh........sshs.lsApAsA	......................................................tuAtphsssss.............ts.ssAp.sss..tpNGh............................ssus............shsltsGpass........sssssppFs.s.uus.................................shNAVpVsssps.............VP..haFsu.h..........sshs..luAousA..............	0	30	60	80
+9811	PF09979	DUF2213		Uncharacterized protein conserved in bacteria (DUF2213)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3566)	Family	Members of this family of bacterial proteins comprise various hypothetical and phage-related proteins. The exact function of these proteins has not, as yet, been determined.	20.90	20.90	20.90	21.00	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.96	0.71	-4.59	32	362	2009-09-11 16:51:15	2007-07-30 16:29:40	4	5	302	0	52	327	29	157.90	31	42.39	CHANGED	ssRphss-GhLlscss.luRsGhphYsucElst.ts......pthlpVhRsPEpVFps-olASF-GhPlTlpHPc......c.VsscNW+slulGtlpNsRR....cu-hllADLllpDtsAIptI.-sG...hcElSsGYcs-a-.ss.......shcucQhsIpGNHlAl.VscGRAGspssl.u.............Dcs	...........................................t-GhLhsps.s..lu+s.G.h..Yhut-lsh.............t..hhl.hRsP-plFpspslsSapuhPlThtHP........thls..scNh.+.p..h.slGpltsstc.......pu.shlhuslhl.......hDps.............uIptI..psG....hcElSsGYpschp....ss.s....................shcu....hQhsI.t.s.NHlAl.V.scG..RuGspstl.tD...............	0	8	33	43
+9812	PF09980	DUF2214		Predicted membrane protein (DUF2214)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3556)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	26.30	26.10	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.91	0.71	-4.46	26	200	2009-01-15 18:05:59	2007-07-30 16:29:53	4	1	198	0	85	192	118	148.80	35	94.81	CHANGED	hlssAllAalHaLuhhhsFuulssEphhLRss.hs..tspstplllsDhlYGluALslLlTGlhRlh.aauKGu-FYhpNPlFahKlsLalllulLSlhPTlsaIpWthslpcspsP..s.shsp+lthllplEhhhhslIPLhAshMARGlGh	....hhpAllAalHaLuhhhhhuslssEt.hhL...Rhs....hs......hsphpplhhhDtlYGluAlsl.LsTGlhRlh.hasK...GssaYlpsPlFHhKluLFlll...uLLSlhPTlshl+W+tsh..+p.....sthP....s...........ucspphtthlphphhLlhlIPLhAshMARGlG................................	0	14	38	65
+9813	PF09981	DUF2218		Uncharacterized protein conserved in bacteria (DUF2218)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3553)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	24.30	24.30	24.30	24.70	22.70	24.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.77	0.72	-3.80	39	357	2009-01-15 18:05:59	2007-07-30 16:30:16	4	8	331	1	97	244	10	88.60	33	72.22	CHANGED	SpuplsTspAoRYLppLCKHauHKhtVpaDsppGclshP....hGpspLpA..sscsLslplpusstpsLsplcpVlscHLpRFAhREs.lplsWp	..............pApl.TscusRYlppLC+Ha.u...HKhs.............sp....a..st..p..p..G.p..lphs..........su.s.spLss..csppLshslpu..spp.slsphcsVlssHlsRFAtREp.lslsWp...................	0	31	62	75
+9814	PF09982	DUF2219		Uncharacterized protein conserved in bacteria (DUF2219)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3528)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	19.00	19.00	22.30	20.50	18.10	16.70	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.86	0.70	-5.59	67	618	2009-01-15 18:05:59	2007-07-30 16:30:29	4	2	571	2	122	391	160	281.60	29	87.86	CHANGED	hth-NDh.hh..u...sDp.tYTsGlplsastss...........thttthsphh...............t..thshpluQphaTPs..ch.....phpss.ssDRPYAGhLhhshshhthpsspt.......phshslGhl.GPsuhucpsQphhHp.llG.......sscsp..GW-pQlcN-hshplshctphphht............shth-ltshspsslG........NlhohsssGsthRhG...pLsssaGsstlp.ss.....ttthh.st..............shuhahasuscsphlspslh.l-Gssa........ppst..sl...shpthhscsphGlshth....t.shplsau....hshtopEFcsppc....hppaGolsluhta	............................................................................................Dp.sYTsGlhLuaopshh................................................shsphuh.pluQchaoPS..sh.........cp..spshhs...DRsau..uaL+sslp..h.u..hssshh...................chshslGsl.GP.sAhupcsQphsHc..lhG.......u-.c.p...uWssQlcN..chshslphhhphp.sh...........shhG..sshslhPpsssshG........NhhphluhGstlphG..pshssc.Ghuhls..st...........h.h.httpp.............shtahlFuGh-tRhlsps....hT..LpGpoh................psph......sV.....slpthVsphplGsshta...........s.shuholu....hsthTsEF+ssc-.......asahshslshhF...........................................	0	45	84	110
+9815	PF09983	DUF2220		Uncharacterized protein conserved in bacteria C-term(DUF2220)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4924)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the C-terminus.	20.50	20.50	20.50	20.80	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.23	0.71	-5.12	31	376	2012-10-01 21:47:57	2007-07-30 16:30:42	4	4	352	0	131	417	28	166.90	19	45.82	CHANGED	GL.......ppcsshlRhRhL-sshsh....sshs-lslshpphupl..plssppllIlENctsaLshP.shs....sulllaGuGauhsplss..hs........WLppp.plhYWGDIDTaGFtILspLRphh.PpscSlLMDppTl.pa.psthstE..sp.pttp....Lst.LossEtslYcpLhpsthtsplRLEQE+IshphlhptL	................................................................................................h....tthtth...th.s.s.pplll.lENpss...a...hshs...phs....................ssl..sla.G....u....G....h.sh.p..t.h.t.p....ht.................................hlps...p...plh..YWGDlDstGh....tI.....hppl+phh....s..........t..........h..p...s....h...h.Ms...tt..h....th....p..hs.p.....st..h.t...........h.t...Lp....t-.hth..hp...tl...ht..............thc.lEQEhl.........h......................................................................	1	53	95	118
+9816	PF09984	DUF2222		Uncharacterized signal transduction histidine kinase domain (DUF2222)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4999)	Family	Members of this family of domains are found in various BarA-like signal transduction histidine kinases, which are involved in the regulation of carbon metabolism via the csrA/csrB regulatory system. The role of this domain has not, as yet, been established.	20.50	20.50	20.60	20.50	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.56	0.71	-4.76	27	713	2009-01-15 18:05:59	2007-07-30 16:30:59	4	8	701	0	82	352	6	146.60	63	16.35	CHANGED	hsRYp-L-cpLlspGsoIIEPLAIASEhGhppcsREsl++LIohsHR+pSslV+SIAlFDssNcLFVTSNaHpsFctLphscshshPphhplphpssolILRoPIluEu...ph....sss.stssssphLGYIAlELshsslpLpQYp-lh	....VHRYNDLQRQLEDAGASIIEPLAVSoEYGMsLQNRESI.GQLISVLHRRHSDIVRAISVYD-.s.NRLFVT..SNFHLDP.Sp..MQ..Lsss........sPFP......RpL.o....VsRcGDl...MILRTPIISES.......................YSP......DESssuDAKsopNMLGYIALELDLKSVRLQQYKEIF..............................	1	11	26	54
+9817	PF09985	DUF2223		Domain of unknown function (DUF2223)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4945)	Family	Members of this family are found in various prokaryotic membrane-anchored proteins predicted to be involved in the regulation of amylopullulanase.	18.60	18.60	19.80	22.60	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.51	0.70	-5.03	16	159	2009-01-15 18:05:59	2007-07-30 16:31:13	4	21	101	2	90	164	135	215.70	27	30.19	CHANGED	hlhphsDPhGDDpGsGsYsYPTsssF.tP..GhFDLhphplh-sussahFphphscl.sNPWsGPpGFShQhlplYlspppGupsssl......sGsNVph..ppsWDhslhls.GW.s..............ushlhsssGsth.....ssshpltssPs.spsIlsplsKphL.t.s.s..phthhllluu.DGYGPDp.hRP.Vu...spus......pWphGGus.......sst..ssssPhVlDlLlPpu..tsQtphLosa..tssphAll...hslsl	...............................h.lhphpDP.GDDpG.s.G.sYsYPssssFp....GhhDLhphplhpt..s....sshhhphphpcl.sNPWs..uP..............sGFShphlplYlc...h...s.p...u.u.ssshht............Ghsssh....ptsWchslhls..G....W.t...............................tshlh.ss.Gsth..............psshpl...tss.s...tssIhsplspphl.t.st......s........sht...hhVhssu.D...Ga...ussp.....hRs.ls...........spss...............tWphGGus.................tstPhlhDhLssps.........tQ...Lt....................h...........................................	1	35	48	69
+9818	PF09986	DUF2225		Uncharacterized protein conserved in bacteria (DUF2225)	COGs, Finn RD, Sammut SJ	anon	COGs (COG1655)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.47	0.70	-4.88	23	252	2012-10-11 20:01:01	2007-07-30 16:31:21	4	3	242	0	98	280	16	223.70	28	87.25	CHANGED	LYcKclpCPVCspcFpscpV+ouuhRlh........++DsDhph+Yps..lNPhaY-VhVCspCGYAAhcpcFs.plsstpp-hlppplss+aps+.......sast..RslspAlpsYKLALls.hplhcs+.S...ppAhssL+lAWlYRhtpc................cppEhhaLppALctaccAYpsEshshp.shscho...............lhYLluELsRRhGspc............-AlpWau+llssssssp....plh-hAR-tacll	...............................................hccplpCPlCsppFpppcl+outh+lh........cc-pDhpscY.ps.....lsPhhYsVhVCPpCGaAuhppc....Fs...p.l...s...stp...t...chlppp.lsp+.h.p.p............sast...RslppAlpsYtL.Al.ls.hph.hp...t.phs...phAhhsL+lAWlaR.hpc.................pppEphahppAhchYpcuhpp-.p.h..s.p..shsphp.....................................................................................lhY..L.lGpLph+hGshc............-Ahpahu+llsptpssp....hlhchAR-.ap....................................	0	51	80	88
+9819	PF09987	DUF2226		Uncharacterized protein conserved in archaea (DUF2226)	COGs, Finn RD, Sammut SJ	anon	COGs (COG1667)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.50	20.50	20.60	20.60	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-12.01	0.70	-5.29	4	41	2009-09-10 17:02:35	2007-07-30 16:31:33	4	5	23	0	31	41	5	233.70	16	84.24	CHANGED	MhhP+s..pVVEschh.....GshcEIhc.luohs...GhlcIos+cG-tLh-uallVpsGKlVushlpclcotEchsuEEAlccLh.......uhpssVlDVYchsc-clphhhchps.....................psls..h.phcl-h.ht.................................................Es..t...s.pth-hsEEhlc-P-..........................................................pREElLKKhGIK.Ps.Ep.lEsILc-hhc.............sshEEhKppl.pph..plh+hpGhs-VhVh.csK.tEt..........sscpllthl++c.................slcEh.ochhR	...............................................................................................................................................................................................................uhl.h....t.....shhhh.tt..lh..................t.h.th..............hl-laphp.p.hphh..........................................................................................................................................................................................ps..t....t.pt.p.h.pphhp..c.p.t........................................................................lsR-cLhKphsl+..s.-p.l-pllcphht...................th...h.pp....h....t.....................................................................................................................................................................	0	9	13	23
+9820	PF09988	DUF2227		Uncharacterized metal-binding protein (DUF2227)	COGs, Finn RD, Sammut SJ	anon	COGs (COG2389)	Domain	Members of this family of hypothetical bacterial proteins possess metal binding properties; however, their exact function has not, as yet, been determined.	25.00	25.00	27.90	27.90	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.28	0.71	-4.62	28	198	2012-10-01 21:01:47	2007-07-30 16:31:49	4	1	192	0	62	150	38	162.70	39	96.84	CHANGED	PSGRsHDRlTl..h.ulPhshlhshh........lsts..huLhs.uuuaLhuGLhhSPDLDlp.S..cthpRWGhLRalWhPYpcll.HRShhSHG.llGohlRLhYLtshshslshllshhh..h.hhshsh.s.h.....thlhphhppp.p.llshllGLEhuuhhHhluDhsssshchh................................+tR+	.................PSGRTHs+IsLh...uLPslhhhha............huhos....hLl......s.uhuaLhGshhLoPDLDha..S.....psap+WGhLRhhWhPYp+lhsHRShhoHshllGsllRlhYhhllhsshhhllshlh..t..............................splhphhpp..ap.hpllshlhGlhluuhLHlIuDtlsoptK+hh..........+...++c......................................	0	16	42	57
+9821	PF09989	DUF2229		CoA enzyme activase uncharacterised domain (DUF2229)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3581)	Family	Members of this family include various bacterial hypothetical proteins, as well as CoA enzyme activases. The exact function of this domain has not, as yet, been defined.	29.40	29.40	29.80	29.40	28.90	29.30	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.43	0.70	-4.88	84	1010	2009-01-15 18:05:59	2007-07-30 16:32:13	4	8	744	0	247	884	34	205.20	36	18.45	CHANGED	plGIPRsLshYc.aPhWt.TFFscLG..ac...VllSstos+clhchGhcshsuEs.CaPsKlhHGHltsLl.c.....Ktl-hIFhPplst.pp.c........tpasCPhltuhP-hl+ssh.........ptshphlsPhlshps......cthtcphhc.h..............hp...l..spc...............-lppAhcpAhcp.cpacp.p...lcppucchlthhptptpp...................sIlLhGRPYpl.Ds.lNhGIschlsp.hGhsVlTtDsl	..........lGIPRsLNhY.EsYPaWt.ThFspL..G..ac...VllSscSo+pla-p.GlcolsS-s.CaPAKlsHGHltsLl..c.......+.slchIFh.....Pslsap....pp...c.........p...ss.spaNCPlVtuYP-sI+sNh........................ptslphhsPalshssp.....ctlhcplhc.h........................hp.h.s.l..stp....................................-hppAlptuh..pc..pta+p.c......lpp.tG..ccslthhpp.pstt............................................uIVLuGRPYHl.DPcINHGIschlss.hGhsVLTEDul.............	0	136	211	231
+9822	PF09990	DUF2231		Predicted membrane protein (DUF2231)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4244)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.00	22.00	22.00	22.10	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.39	0.72	-3.68	51	367	2009-01-15 18:05:59	2007-07-30 16:32:28	4	6	261	0	187	377	94	102.30	23	55.45	CHANGED	ah-luaWslhsuslhshhAslhGhhEhhLs.shh...........tspsshhhHslsulsllulhss........palhRhcssp..pl.hhhLsluhlhssllslpuaLGupLsacaGlt	.......................................................h.psuhW.lhsuhlsuhhAslsGhh.-hhhs....tt......................psppshhhHslhslshhslhss.....................phhhRtp...sst.....tl......h..........h..hL.hlu.hls..hs.llslsuaLGupLsapaGlt.........	0	46	119	163
+9823	PF09991	DUF2232		Predicted membrane protein (DUF2232)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4241)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	24.90	24.90	25.00	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.72	0.70	-5.42	46	942	2012-10-03 02:46:00	2007-07-30 16:32:53	4	5	917	0	226	724	132	260.60	20	81.98	CHANGED	ulhsllhl..lsha.lPlluhlhshhhPlPhllhhh+puhphulh..sllssh.llhhlhss.hhu..lhhhlhhulhGlllGhhl+cppshtps.....lhhushshlluhllhahlhhhhhs....ls...hhsthhphhcpshppshphhpph.Gh.....s.....tphpchhpph.hphlthllPuhlllsuhlhuhlshllst.ll..+Rhphp.h.thssFppaphPppllWhhllsllhhhhhpt.sh....phlhhNlhhllshlhhlQGlullhaah+p+.phspsltl...lhhllsllhs..lhhlltlLGllDl	..............................................................h..hhlhhh..lshh.lP.h.lu...h..l...hthhhslPhhllhh+.t.........t.......p...hulh....uhlssh.....llssl..l.u.....s.s..h.s..........lhhh.l..hhhl.hul....llG..h..h..h.....+...c.....p.pshtph........................lhhs....s.ls..h.h.l.hh...ll.hh.hl.ht.h.hht...........ls......hs.....h.h.p.hp..ps.hpp..s..h..p.h.httt................................tt.pp.hhpph....hp.hth..hhPuhlllhs....hhhshlshhls.h...ll.....p+h.t.h.....s...h.s..h.s......h...t.hph.s.....t.....h.lhhh....h..l....slh...hh.h..h....h.t.........s....................lh...h.N.h.hl.hshhhh.lpG.luhltah..hpt+...thsthh.hh...lh..h..lhh.hhhs....hh.llhllGlhDh......................................................................	0	85	164	200
+9824	PF09992	DUF2233		Predicted periplasmic protein (DUF2233)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3698)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.10	25.10	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.76	0.71	-4.24	288	1904	2009-01-15 18:05:59	2007-07-30 16:34:37	4	62	1410	1	489	1560	149	177.80	21	44.80	CHANGED	ppslhulN......u.....s...h....hs.ptt...................s.G.hhlp.......sG..phht...............sttttshhshp.........tsuthhh..............shpphth........tshpps.l..t.G...........P..hLl.p............sGp.......hh............t.sssst........................tsRoAlGhs.....pcG..pllhls....l-G.....t......tGh.olt-hup.lh...p......h.Gsh.s.....AlNLDGGuSoshh......................hth..h...spP....ssst.................Rslssslhlh	................................................................................................................................t..h.huhN..uu...h......ap.p.t..............................shG..hhlp............sG...phlt..................ttspststhhlp............................sGhhhl.................s.....h....................................................................pshp.u.l....suG...........PhLl.p......................................sGp.........ls..............p..tss............................................sppsRoulGhs..........ccG....pllhll...s-s........................uh.shh-hAp.hhps.......L..G.s...s.............AltLDGGuSoshhh..........................t..h.........s..............................R.l.shhh..t........................................	0	212	355	421
+9826	PF09994	DUF2235		Uncharacterized alpha/beta hydrolase domain (DUF2235)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3673)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	21.10	21.10	21.80	21.70	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.00	0.70	-5.03	90	1245	2012-10-03 11:45:05	2007-07-30 16:35:17	4	29	586	0	602	1402	86	226.40	21	51.26	CHANGED	+...pl.l.lChDGTs.....Nshpsstp.............................oNVh+la.chl..........spss............pQhsa...............YpsGlGT...............................tpthpphhssAh...Gtuhspplh....pA........YpF.........LhcpY....psGDc...Ia.....lFGFSRGAasAR........sLA.shl..sphGL.........lp.......................hhhhsacthtp..................at.ttht.t.pt...................phhtthppphs........................p.ssplcFlGlaDTVsul........................................stahhp...............th.....ssth...........sst.................VcpspHAlulDEpRttFp.s....Lhp.......................................................................................................................................sssttsp.......ppVWFsG..sHuDl...........GG...Gas..............ttpttLSc.lsLsWMlpcA	..............................................................................h.lhhDGT........pp.ttt....................................................oNlhclh.phh...................tt........................................hh.h............Y............GlGo.............................................t....h.t.hhs.sh.......u..........s...htt...pl....tu.........................................................hth..................lhp.h..............ssp.......lh............................hhGF...SRGAhhsR..........hs..thl......................................................................................................................................................................................................................................................................................hplphl.GlaDTVsul...............................................................................................h..t..................h.....h.h........................s..................sphshHhlu..hc..EpR...ht.F..s..ht...........................................................................................................................................................................h.phhasG..sHu...Dl..................GGGh............................................hs...hsh...hh.......................................................................................................................................................................................	0	164	331	481
+9827	PF09995	DUF2236		Uncharacterized protein conserved in bacteria (DUF2236)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3662)	Family	This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	21.50	21.50	21.60	21.50	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.35	0.70	-5.08	128	1684	2009-09-11 16:50:31	2007-07-30 16:35:46	4	16	655	0	676	1614	392	240.60	18	70.56	CHANGED	hshcsatchssh...hhsussullhphhpPtlstulhcp................usap..............p..csht........RltcTspalhsss...................au.sspputthttcVRthHtpV+us.......hss............................G....tsYsAhssplhhWstsshshshl.tuhpt....h.sh.lsss-t-phapphthluphlGl..c.h..Ppotsphtphhpphh.pt.lpsstps+pl.sphlht................hsss..hhh.......t.hhthhh........hhshshLsstspc.hlGlshsshtpth....hhhhhht........tshthl.ttl	...............................................................................................h.......p.......hhhshtulhh..p..h.hhPtlstulhcp....................upht.......................p..cs...hp.........RhtcTstalhsss................................as..ssp.....utt..httpV+.thH.tplcus...p..........................................................G........h..a.ps.s.stlhhastsshhhshl...pshcp.......h..s....t..............l.o.t.t-.t-phap.p..h.thhuph.h.............Gl................c..h.............Ptoh..........t..........pht..........p..........ahcp......h..........h................p.....lp...s..sttscpl..hphlht.................hsh....h..................t.ht..thhh..............hhshshl.s..shh..pc...hhs.l....hsshtpth.......hhh.hht...............hh........h............................................................................................................	0	164	398	587
+9828	PF09996	DUF2237		Uncharacterized protein conserved in bacteria (DUF2237)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3651)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.40	25.40	22.90	19.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.54	0.71	-4.61	79	426	2009-01-15 18:05:59	2007-07-30 16:36:10	4	2	408	3	165	373	1622	108.90	51	88.89	CHANGED	shNVLGpsLpsCussPhTGFaRDGtCpTsspDhGsHoVCAhhTsEFLpaS+tpGNDLSTPtPcasFPGLKPGD+WCLCAsRWhcAh-sGhAP.VhLcATHppAL-lVsL-sL+paAh	..................................t.hNVLGtsLps..Cu...p..c...P.....h.....TGFaRDGhCpTsspDhGpHoVCAlhT...sEFLpao+u.h.GN.DLoTPhPpa..s..........FPGLcPGD+WClCAsRWhcA......h........p...........s...........G........h..AP.VhLpATHppsL-hlsL-hLppaA.h............................	0	60	121	149
+9829	PF09997	DUF2238		Predicted membrane protein (DUF2238)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3647)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.30	26.30	26.40	26.90	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.88	0.71	-4.80	67	737	2009-01-15 18:05:59	2007-07-30 16:36:24	4	1	709	0	132	449	45	140.30	50	68.56	CHANGED	sllshslLhhoh+.+F..hoshsYhLlhlahhlhhlGuH.YTYAcVPhhsW........lp-hhGhpRN..pYDRluHFh.Ghl.Ahsh+ElllRpphl......ps..thhhhhslshshulSAhYEllEWhsAlhs.G.csutAFLGoQGDlWDsQpDMhhA	...............................................................llllslLlsTt+.Ras.L.TsLhYsLIFhasllLhVGGp.YTYAcVPls...............lp-hl.Gh.o...RN....sYD+LGHFhQGLlPAlls...RElLlRthhl........+s.tthlsFLlsslsLAlSAhYELIEWWsAlsh.G.puA-s.FLG..TQGD.WDTQpDMhsA.................	0	36	83	113
+9830	PF09998	DUF2239		Uncharacterized protein conserved in bacteria (DUF2239)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3644)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	35.60	29.20	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.27	0.71	-4.68	37	209	2009-01-15 18:05:59	2007-07-30 16:36:37	4	3	197	0	74	206	12	178.10	51	91.18	CHANGED	tsaTAFpGpRRlAoGsLh-VALAl+...tths.tsssuslLlFDDsTGRslDlDLRGoss-lhARhs.sss......................stsut...........PR...GRGRPKLGVVAREVTLLPRHW-WLuuQPGGASsALR+LV--ARRsssspDRtRtAp-AAY+FMoAhAGDLPGFEEAsRALaAsDtsphsphhtuWPsDlRsHAhtLA	.......saTAFsGpRplAuGsLspVAlAlKpths....ttssuslLlFDcsTG+slDlDlRGosp-lhuRhs.s....................................tsttsR..GhGRPKLGVVAREVTLLPRHW-WLusQPGGASVsLRKLV-cARRspsst-+tRtAp-tAY+FMSAhAGDhPGFEEAsRALaAsDtsthtphIsuWPsDVR-ashtLA.........................................................................	0	14	32	54
+9831	PF09999	DUF2240		Uncharacterized protein conserved in archaea (DUF2240)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3612)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.00	20.00	20.10	21.60	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.50	0.71	-4.75	16	65	2009-01-15 18:05:59	2007-07-30 16:36:58	4	3	65	0	51	72	48	134.50	29	87.88	CHANGED	pL+hsVAAPF+p..ptsspLscs-FlauLohDp+WhSP-pApcllctAtppGLLpp.csGslsssFDsuslplPhuF+Pscslh.................ppcssaEclLDtlsusuGls+p-lVuclNp.hp-pls..lsh-sAulllA+chGlDls....shhpcl	.................LphslAsPFcp..cupsplscsEFlhsLohDhcWhSs-pAKcLl-hAhpcGLlpc.csstlhssFDssplplP.sFpPs..tphh.................pccssF-cll-hlss.tGhs+pEslutlNp.hpcchu..lsh-sAAllhA+cpGlDlschhpc.h.......	2	10	34	44
+9832	PF10000	ACT_3	DUF2241;	ACT domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG3602)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241.	25.00	25.00	28.70	28.20	22.90	18.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.50	0.72	-4.25	48	273	2012-10-02 00:29:19	2007-07-30 16:37:16	4	9	265	4	97	252	79	71.00	38	48.18	CHANGED	MsGEp-LspLLpoMpPpLpsupaVFCols......shst.hsLpsl.usF+EpEGlTllLpcppAcptGL.saphsh+h	........MsG.psLptLLpoMsPpLpsGsYVFsTls............shssh.sl..pPl..uoFREs..EGLTLllppcpApptGL..shphhht................	0	19	48	76
+9833	PF10001	DUF2242		Uncharacterized protein conserved in bacteria (DUF2242)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4259)	Family	This domain is found in various hypothetical bacterial proteins, and has no known function.	25.00	25.00	80.60	80.40	22.70	17.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.53	0.71	-4.24	15	159	2009-01-15 18:05:59	2007-07-30 16:37:31	4	1	154	0	57	182	20	120.40	59	41.58	CHANGED	CEAARRALLSQGYllssucsctV-GpKsFQ.PcsDsHlplphRVVCAscshcushollFssALQDRYALKKosNSASVGVGuLGSlSLPhuSscDoLVKVuSETIsuupFY-RFFpLlc+YL	..CEAARRALLSQGYllouuc.sctV-GsKsFQ..PssDsHlpIsF+VVCAss..s.....tDGspShsaVNAlQDRYuLKKosTSASVGluVLGSlSLPIGSoDDShVKVASETlsuutFY-RFFsLV-paL..	0	5	21	41
+9834	PF10002	DUF2243		Predicted membrane protein (DUF2243)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4329)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	55.00	54.50	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.05	0.71	-4.41	22	165	2009-09-14 14:06:24	2007-07-30 16:37:41	4	1	162	0	73	156	1	137.90	42	79.08	CHANGED	uGlLlGlGLuuFlDtIlhHQlLQWHHhhsp.......................shclshl.DGLFHuhoalhslsGlhlLh...sh+pchsass+thhGulLlGhGhFpLh-GllsHplLtlHpV+....ssphLhaDlua.s.hGhlhllhGhhLlpps.pp	......uGlLhGlGLs.uFlDtllhHQLLpWHHhhsps.......................shclslluDGLFHAhoahhslsGLalLh...sh+R...+tsash+thhuulllGhGsFpLh-GllpH+lLtlHplRh................ss.shLh....aDlsa.l.huslhllhGhlLhhpsts.....	0	18	47	61
+9835	PF10003	DUF2244		Integral membrane protein (DUF2244)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5488)	Family	This domain, found in various bacterial hypothetical and putative membrane proteins, has no known function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.45	0.71	-4.81	79	402	2009-01-15 18:05:59	2007-07-30 16:38:12	4	2	380	0	144	369	562	136.80	29	81.50	CHANGED	LpPppSLs.cuahhhhsshsslshhsulshh.hhGu.WsllsFhGL-lhulhhAhphshRpupttEplslsstphhlh+psspGptpcachNshWs+lphctpst..h..tlsLpupG+cVclGsFLu.--RtsltppLppAL	............LpPppSLu.ptFhhhhsslsshshhhuhhhh.hhGA.WslhsF.hGl-.llslhhAFthsh..R.pApshEcIslst.phhlhchsssu.chppachNPhWsRlchtppsc................tlpltucGcpl.lG.p.FLs.c-RtphAptLptuL.........................	0	33	78	107
+9836	PF10004	DUF2247		Uncharacterized protein conserved in bacteria (DUF2247)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4304)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.40	25.20	23.40	24.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.82	0.71	-4.53	10	135	2009-01-15 18:05:59	2007-07-30 16:38:36	4	1	131	0	18	82	1	158.70	35	97.50	CHANGED	Mppsh...........hhtpthchsW+slhhGhppph.....lupcsVspaAhchlshuspspp...ElhLtlstchsspclsplLssLss........p.ppphptsh+KWh.alhLshlacspp-hsDsLcclEcIYADFsYPE-ltpFlpYMPscs...s..hs.ppNpcRlhspaccaLcp-puc	...................................................l........-hpsp+l+LSWcDIh...WGYpp....Kh.........luassls..saA.ch...hohu-pspt.....hcL.uh.ts+.sh.Elp.lL--Lus.............cpcsho.cpWL.all...Ls...cl.F.pp..+..cpap.-PLtcVEcIYsDFDYPE-I-SFVpYMPspDt..h.PstaohcENhtRLascWccYLssts..t......	0	4	12	16
+9837	PF10005	DUF2248		Uncharacterized protein conserved in bacteria (DUF2248)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4307)	Family	Members of this family of hypothetical bacterial proteins have no known function.	22.50	22.50	22.70	22.70	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.21	0.70	-5.52	49	377	2009-01-15 18:05:59	2007-07-30 16:38:49	4	1	332	0	127	355	70	318.00	43	91.29	CHANGED	pCssCup.laF-NstChpCustLGasP..pptplhslps.....ssps.....ap..................................................................................tha+hCsN.tshssCNWhlsscss...pshChuCchs+slPDLup...spNhttWpclEtAKRRLlYsLh+LGL.....Plhs+.....p..DsttGLsF-FLu-.....sssts.VhTGHssGlITlNluEADDucREphRpphsEPYRTLLGHFRHElGHYY...WspLlt.ss..shLttFRslFGD.EctDYutALppHYpsGP.P.ssWpppalSuYAouHPWEDWAETWAHYLHlhDsL-TAtuaGlplps...p.......th.........hshcPhpss.........shpp.llstWlPLohulNulNRSMGpsDhYPFVLsssVlcKLpFlHpll	...................................pC.pCsp...lhFENstChpCustLGa..pphtlhslts.....stts.......h....................................................................................t...........t.hphCsN.tthstCNWll..s.......ssss............ssh....ChuCphscphPs.ss...sts.htpWt+hEsAKRRLlhpLhcLtL.Plhs+....pp..DsptGLuFchLu....................sstpt.VhTGHssGlITlsluEuDDscREphR.hp.MsEPYRTLLGHFRHElGHY..Y.aspLlt....ss....s....hLptFR.plFGD.-ctDYstALp+HYpp.GsP..ssWp-sal.S.u.YAThHPaEDWAETaAHY.LHIhDsL-TAtuhGlsht................shp..........hshsshtss....sFpp.llp.tWlPLohulNplNRSMGpsDhYPFVLsssVlcKLcFlHpll..................................................	0	35	76	101
+9838	PF10006	DUF2249		Uncharacterized conserved protein (DUF2249)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4309)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.40	24.40	24.40	24.40	24.30	24.00	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.25	0.72	-4.40	163	821	2012-10-01 20:42:06	2007-07-30 16:39:03	4	21	465	0	266	571	35	68.20	30	60.34	CHANGED	plDlRsl..sstp+astIhsshssLtsGcs....hhllsc+-PhPLhtplptc......uh.saphhppssst.aclplp+	..........LDlRsl..sshp.astIhushssLpsGps....hhlls..s+..cPhP..L.htpLcpc.........Gt.paphhppusst...Wclpls....................................	0	76	190	239
+9839	PF10007	DUF2250		Uncharacterized protein conserved in archaea (DUF2250)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4344)	Family	Members of this family of hypothetical archaeal proteins have no known function.	24.40	24.40	24.40	24.40	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.90	0.72	-4.08	18	100	2012-10-04 14:01:12	2007-07-30 16:39:16	4	4	63	0	53	98	6	90.80	35	76.76	CHANGED	hcplhpc.hhLplLpHLccuslDYuKslschoclPLpcVpchLccLcchGLlE+ss.usolKpo-sKhKhupEVH+HHTYYpLoRcG-hlLRcl	...................h.....c.htlpILtaL.cc.h.s.sDY.u+h..lA+.....p.....h........chsLp-lpchlccLEchGLlERsp.up.......hl.Kps.....ct.......+h..K........pp.Es++...HHs....YYcLoRcG-hllRp................	0	15	32	47
+9840	PF10008	DUF2251		Uncharacterized protein conserved in bacteria (DUF2251)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4316)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	33.70	41.00	22.80	16.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.21	0.72	-3.87	9	172	2009-09-10 23:17:17	2007-07-30 16:40:18	4	1	172	0	20	82	1	95.30	56	69.74	CHANGED	hltupS..ps+huVVFEDDG-TGYFYALDhp.p.tpPIlDuLalYNVpslo..stctPpclpItWS-DGhpAhLlINGYPHAlFDFsphhGYs+otaP.P	........h..topu..cthhusVFEDDGpTGYFYAhD.p.....p......tssIlDALHIYNVE.DlS..Dt..H..I........PscVcIsWsEsuphssLLINGYPHAsFDFsppsGYCRsGFP.P.........	0	6	14	19
+9841	PF10009	DUF2252		Uncharacterized protein conserved in bacteria (DUF2252)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4320)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.30	22.30	22.40	22.40	21.70	22.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.18	0.70	-5.56	62	553	2012-10-02 22:05:25	2007-07-30 16:45:36	4	4	397	0	238	582	38	375.30	28	85.90	CHANGED	R....hspLlshRat+MusSPFuFaRGoAtlhtpDLss........ssssuhps.lCGDsHltNFGhau...ss-tpllFDlNDFDEshhGPapWDL+RLusSlslAucpp.uh.....................scppspphlpshspuYpcphpphuphshhphh..................hpspsspthlpchhc+App+.sptphhs+hophs........sthRhhp.psstlhtls................pstpptlppthppYhpols..sscp.hhsp....aplpDlAh+l.sGlGSlGhpsahlLlpuptps...c.sl..lLplKcAptSslstah.....tt.....tppGcRVVtuQRhhQusuDhaLGasphss..............+...s......FhlRplpshKsslsh..cp...h....st..cphtpauchhGtsLA+AHA+.us...css................hlsshhupscphs..pslscaAhpYAcQscpDattahcs	.................................................................spLlslRat+Mus..SPFuFaR..GoAtlhtt.DLsp.............................tsssuhtl.lsGDsHltNFGhas...ssctpllFDlNDFDEshhGPapWDl+RLusSlslAucpp.uh...................sppptpphlpshspuYcpphpphsphsh.phh.........................................................htsppspthlpchlp.+Appc..s......ptphhs+hTphs.t...........sth+hh...t..psshhhtls.........................psptt.tltshh..p.p..Y.h...po..l.......tst...th.h..hsp....aplhDlsh+l.lGlGSlGhpsahlLlpupsss.....s.sl......lLplKEAt.s..ushs.ah...............t...............tppGcRVVtuQRhhQssuDshLGas.p..hss...............+.s......................ahVRphpsh+tslch..sp.....l......s.....pphtthuphhutsLApAHA+.us....sss...................hlssh.h..u..p..s.cphc....pslspaAhtYuspsctDattahp...................................................	0	67	139	199
+9843	PF10011	DUF2254		Predicted membrane protein (DUF2254)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4325)	Family	Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	22.30	22.30	22.50	22.70	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.94	0.70	-5.99	89	512	2012-10-02 20:27:15	2007-07-30 16:46:06	4	3	472	0	161	484	58	341.10	25	80.16	CHANGED	lppplWhhPslhulhullhuhlshhl-t....hhs..........hshhhtsss-uscslLoslAuohluVsshohSlhlsulstASuphoPRll.phhhpDpssQhsLusFlGoFlYuLlsLhslcssh.t................sspls.h.hhslllsllslhsLlhalcHlsphhplssslppltppsppslpphhpp.thss....sspsth.ts.......................ltutpsGYlQtI-hpsLtchApc..psshltltstsGsFVhtupslshh.......................pth..sccptcpltps....hslGppRohpQDspFGlppLsEIAhRALSPGlNDPsTAlsslspLsplLsp....................h.sshhtspps...sRlhl.shs.h..pcllcpuFstlpp.uussht.....Vhh+lhpsLtpl	...........................h..pplWhhsshhslh.ulhhuhlh.hh.hct.hhs............thhhps.ss-sscslLssluuohlslsshshSlhlsuhs.AouphoPRhh.phhl.c.Dp.ssQssLuhFluoFlaullslhslptst.st..............hspls..hhhslhlhhls..lhsllhalp.+lsp.hplsphhsplpptsh.p.s.lpphhtp.s..phs...s..............s.t..t.......t.ths.....................................lhutpsG....YlptlchspLtp....hs.pp......pph.plhlhstsGsalh.utslhhl...........................................tt.s....p.p..h..pp....lhps....hhlutpRohpQD.pFulp.lsEIAhRALSPulNDPsTAlpslsplsplLsh...............hht.t.sp.hhh..ttt................plhl...hs.h..pchlcssFs.ltp.uuspht.....VhhplhpsLtt..............................................	0	56	107	135
+9844	PF10012	DUF2255		Uncharacterized protein conserved in bacteria (DUF2255)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4334)	Family	Members of this family of hypothetical bacterial proteins have no known function.	29.70	29.70	29.90	29.80	29.00	29.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.41	0.71	-4.13	14	98	2009-01-15 18:05:59	2007-07-30 16:46:22	4	3	93	0	40	99	4	111.40	34	86.82	CHANGED	--Lc+IspA-DL+IAPaRcDGpThuTPTWIWsVhV-scLaVRuYpGpsScWapuAlsQ+AG+IpAuGhst-VsF-sl...Dssls-pIDsAYRsKYup.StYlsPMls.tcARuATl+lh	....................-Lsplspu--lpluPhctDG.ThtpsshIWsVhlsscLYVRuhpGpp.SpWYpuAhsppsG+IpsuGhphpVsFtss....DttlpsplDpAYRpKYut..s.hlss.Mls.ttsRsuTl+l.h.............	0	16	31	34
+9845	PF10013	DUF2256		Uncharacterized protein conserved in bacteria (DUF2256)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4338)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	25.20	26.80	24.60	21.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.61	0.72	-4.20	71	341	2012-10-03 05:12:49	2007-07-30 16:46:39	4	2	336	0	116	321	140	41.70	59	69.36	CHANGED	t+KspLPp.KhCslCtRPFsWRKKWp+sW-pV+YCS-RCR..+p+	......+KspLPp.KlCsVCtRPFsWRKKWt..+sWD-V+YCSERCRRp+.....	0	42	83	101
+9846	PF10014	2OG-Fe_Oxy_2	DUF2257; BsmA;	2OG-Fe dioxygenase	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4340)	Family	This family contains 2-oxoglutarate (2OG) and Fe-dependent dioxygenases. It includes L-isoleucine dioxygenase (IDO) [1].	23.10	23.10	23.40	23.30	22.30	22.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.20	0.71	-4.92	113	432	2012-10-10 13:59:34	2007-07-30 16:46:58	4	4	397	2	130	367	28	193.40	28	79.36	CHANGED	htssass.LshDpahsst...aRhRRaupathpsss......lhth.......scpsahQssp..aNth..pGul.RpFpsls..sshhpssshppllphhhphhsthp...........pshplplHQhRlpsssst...upsoPEGlHpDGhDal.hlhhlsR.pNl...pGGpopl...........asssppthhphpltcsh-slllsD..pclhHtlTPlpshsssp.......uaRDlLlloa	..........................................................................................tssasp.LshDsahsst........aRhRRYuphthpssp..........lh.h.........scpsahQosp....hNth..pGslhRpFpslp..sshlpssshppllthhhphsshss............shplplHQhRltAs.sp....u.ssPEGlHpDGhDal.slhhlsR.pNl.....tGG-shl...............hps.s.p.ptshhhplhcsh-shllsD..pclhHssoPlpshsssp.......uaRDlhVlT............	0	28	70	103
+9847	PF10015	DUF2258		Uncharacterized protein conserved in archaea (DUF2258)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4345)	Family	Members of this family of hypothetical bacterial archaeal have no known function.  Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	61.80	61.80	22.80	18.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.44	0.72	-4.17	10	57	2009-01-15 18:05:59	2007-07-30 16:47:08	4	1	53	0	39	54	0	76.90	44	43.67	CHANGED	ELsTGlVIAuuYADKLRRVlFAsl.....pstlssc-llRssuELN+pLF-hLVpchclsKhDVVRIpV-..Yslc-uKlha	.ELsTGllIAutYADKlRRshaAth.....pphlsp-pllRssuELN+tLYcpll.chplsKhDVVRIsV-..aclcss+lha.......	0	9	18	27
+9848	PF10016	DUF2259		Predicted secreted protein (DUF2259)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5497)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.70	26.20	19.10	24.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.14	0.71	-4.59	13	87	2009-01-15 18:05:59	2007-07-30 16:47:21	4	2	83	0	35	83	3	188.10	26	82.36	CHANGED	AFtpaGlpDGSGFPYAslahlDstpspFl.sushRsphsc-su.......sLsthhpcspppspshh.stthpscsshhss.sshoEh.........oucsaplhlhs+ss.sshctshpLplpp...hshs.st.htsht.cshGFpL..htt.suspsphlpts+ulP.uRsCshsYcIcpVhl...psspsshlhlltscphGFEG.PstR..alslss+	.........hFtpYGhp-G...h.sYuslYhlDlspssFlpu.ushppphpccht.......sLh.p.hhpptphtspphthsth..hpup.hhhhsp.s...lsEh.........................suspaplhlshch..s...tthsssaplpLp.....................................phssushpc.tlpss+s.sh.RtsshsY+Icclhl....sspsshlhllchh.hs.pG.tshR..ahs.sh+........................................................................	0	11	22	26
+9849	PF10017	Methyltransf_33	DUF2260;	Histidine-specific methyltransferase, SAM-dependent	COGs, Finn RD, Sammut SJ	anon	COGs (COG4301)	Family	The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring [1].	23.00	23.00	23.20	24.50	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.37	0.71	-4.25	314	818	2009-01-15 18:05:59	2007-07-30 16:47:50	4	20	692	0	412	836	262	124.80	34	32.13	CHANGED	GlDLh....K-sshL.sAYsDutGVT.....AtFNhNl.Lp+lN+cLs...uc.............FchssFcHh......Aha..sspps...c.lEMaLhupcspsVpls......s........hsh..pFttGEpI+....TE.ShKash.....cphptlhpp.................AGhpstphWsDsps.hFulhl	...............................GhDLsKDsshLhtAYsDutG..VT.................AtFNhNl.Lpcl..NccLs..u-.............Fchcs.FpHh........Aha......ssppp...R.IEMaLhupcspsVpls.........t.........shthpFptGEplc....TE.ShKas......cphpthhpt.................A.GhphtphWoDsps.Fulh........................................	0	120	255	343
+9850	PF10018	Med4	VDRIP; 	Vitamin-D-receptor interacting Mediator subunit 4	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4552)	Family	Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter [1][2].	25.50	25.50	25.60	26.10	25.20	25.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.32	0.71	-4.89	33	292	2009-01-15 18:05:59	2007-07-30 16:58:54	4	8	248	0	212	284	0	182.90	23	60.52	CHANGED	hphhppLlst-cpLppslcpLpcapchppclppLcp-spplDppl+pllcpLtshcppLpshs......t.pp........................tshsptppppls......sc-LLcYA++ISKaops........................................................................................htPssah........t..h.Pa.PtE-phRtGhLuphshtss...t..h.pstpp.....................................ssstsptpsptttpppss	................................................t.thhphLlptDpplpptlch.........h.tpptph.ppchppLcp-scphD.p....c.lppl.cpLpcscp.Lssss.......sppch..........................................pshtpspcttl..s......sc-llcYA+R.ISttsts....................................................................................................................tP.sah...........t..hhPa.Ps-.phRtGhLuphp...st.th.............................................................................ttssttthttt..............................................................................	0	60	104	170
+9852	PF10020	DUF2262		Uncharacterized protein conserved in bacteria (DUF2262)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4296)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.60	25.60	25.60	26.20	24.70	25.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.99	0.71	-4.01	50	250	2009-09-11 11:06:32	2007-07-30 17:17:49	4	5	177	0	44	249	1	141.30	24	59.29	CHANGED	p-phlGsFphs+pht..ta-uphphh.spp.lplph...............t.stpccpphpp...slp....thcc...................l.......hpphcchccpl+phsucc..ll-lAN-.Whps..................s-p................................loc-cFhpplpLs...slslpscu.........shphaasDs....DhFhGHslhVpsshstshp..susl	.......................................................hGphhhs+php...hapsphphh...spp.lpl.h..................stppppthpp...hh.pthcc...........................hhtphcpac.pch+phhucc...LlchAN-.Whc.p..................c-pt...............................lTcEpFtpplp..lp...slslptss.........shshaacDs....DlFhGHsIhlshshctslhsApl..................	0	24	33	34
+9853	PF10021	DUF2263		Uncharacterized protein conserved in bacteria (DUF2263)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4295)	Family	This domain, found in various hypothetical bacterial and eukaryotic proteins, has no known function.	19.30	19.30	20.80	19.80	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.92	0.71	-4.21	20	353	2009-01-15 18:05:59	2007-07-30 17:18:14	4	11	248	4	211	358	19	139.00	26	40.87	CHANGED	ApETlsll...........ssGhYlsssustlslptphctu.hpsophasPs.h..............s..pTtlcVssssThsuA....ppLsp........ssppVslLNFASA+NPGGGalsGApAQEEsLsRsSuLYhsLhp.....h...Ythp+tppshhYoDth...IYSPsVPlFR-c	.............................................................................................................p.hh...t.........................................tt.splpVh.s.tsolpuA..................hpLtt........................tttpluVLNhASsppP..GGG.ahsG.At.A.QEEsLC+pSsLhssLpp......h...Y......p...t..........t..t.....hYs.th..................IYSPsVhVaRs.......................................	3	74	132	181
+9854	PF10022	DUF2264		Uncharacterized protein conserved in bacteria (DUF2264)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4289)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	30.60	26.80	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.98	0.70	-5.80	52	781	2009-01-15 18:05:59	2007-07-30 17:23:14	4	6	507	0	203	599	25	287.20	29	59.32	CHANGED	psRpp.............hhpshpplhpslhshh.upspt+hsh.spossta....sppss..s.lEuauRsLhGlAPhLpt........tt........phh-hhhcultsGsDP...pss-YWshhpst.s...QplVEsAsluhuLhhu.ctlWpsLsptp+pplhpaLpphp.phphspsNWhhFplhlphsLpph.Ghth-p...tlcpslpclcp.aYl...........GDGWYsDGs.........................thphDYYs.uauhHhhhlhhsphhscpc.t.........hhpphppRtpcFuppa.+hhus-Gsh.saGRSlsYRhAshuhhuthuhtph....tsl.s.Gpl+shhppsl+hahsps.shasps......GhLolGashsp.thsEsYsusGSsYWuh+uF.lsLuLPtscsFWoutppshs	.....................................t.sht.h.thh.phhtsl...h.s.tt.....thph.stttshh............sptts..p.hEuhsRshhshushht.......................................hhphhhpulhtGsc.P...pp.s.pY.h....s...ht.sh................QhhVEhu.luhsLhhs..p.hWp.Lstppppplhpah.t.p.hp.php...hs..sNWhhFplhlphhLpph.Gh.hst..............hp.thth.hc.p..aYh...........GsGWatDGs.........................th..thDYYs.uashp.h.h..hhphh.ct.t..................hthhhpRht.astt...h.hhhs.p.....G.th...hGRShsYRhA.ht.huthsht........th........h.s.G.h+..thhtttl+hahpp...thhstp......GhLolGa.h.....h...p.h...hu-sYsusGSsYWuh+sF.lsLulPtscsaWps.tpsh....................	0	61	135	180
+9855	PF10023	DUF2265		Predicted aminopeptidase (DUF2265)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4324)	Family	Members of this family of bacterial proteins comprise various hypothetical proteins and putative aminopeptidases. Their exact function, has not, as yet, been defined.	25.00	25.00	26.30	25.30	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.99	0.70	-5.30	26	162	2009-01-15 18:05:59	2007-07-30 17:23:26	4	1	160	0	64	186	97	334.50	43	92.38	CHANGED	hhhlhhshhLuGCss.......luYYhQuspGplplMpttcPlcchlsDs..sssstL+pRLthupphRpFAsp-LtLPDNsSYRpYA-LpRPaVVWNVhAsPchSLp.+pWCFPlsGCVuYRGYFspssA+stAspLpppGhDstVtGVsAYSTLG.....WF....sDPLLsTFlt.as-s-LApLlFHELAHQslYlpsDTsFNESFATsVEp.GlcpWL...A............ppusssscspatthcpRRpQFpuLlhsTRpcLptLYtsshsssptptt....KtthhpphRpcYupL+sp.W..................uGhuuYDtWhspslNNAcLushusYsphVPAFpuLacpsstc............WsRFYsuVcpL..upLPts-RctsLp	...............h..hhhshhLuGCss.......luYYhQ.spGphpLlps+cPlsclluDP.....spsstL+p+L..tpupphRpFAoccLtLPDNpSYRhYA-LsRPaVVWNVhAsPEhSLpshpaCFPlsGCVuYRGYaspusA+upAstL+tpGhDVhluGV.AYSTLG.....WF....sDPlLSohlt.as-...t...cLAsLIFHELAHQphYlcs....................DTtFNESaAohVEppGscpWh....t...............tp..u..t.s..stpsph..pp...tRRpQFttLlLsoRpRLcsLYss.s..l..s..sstp...Rst....KsthFppLRpcYtpL+sp..W......................uG...ptaD.t.Whsp.P..h...NNAcLhshuhYcpaVPAFtsLF.cps.sGD............WspFYstVcpL..up..LPh.tpRptsL...................	0	16	35	51
+9857	PF10025	DUF2267		Uncharacterized conserved protein (DUF2267)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5502)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.20	25.20	25.20	28.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.64	0.71	-4.06	135	355	2009-01-15 18:05:59	2007-07-30 17:24:29	4	7	195	1	178	362	14	123.70	24	78.49	CHANGED	chp.palpclppcssh.ss............pppAhpsscuVLpsLtcRLsscputcLAupL..............Ph.lpshhhp........stttssp.........hstccFlp+lup.h...............pt..spt........sucpsspAVhsslpctlstsch.cclh.spLP.....p.shcpLa	.....................hppalpplppcssh..s............cppAhpsscuVLpsLt-RLssp.......pstcLuupL..............P..lpshhhp..............sttsstp..........hshccFlp+lup..h................ss....sst........ssctsspAVhsslpctlstsph.cclhspLP.....p.shptLa...................	0	41	114	159
+9858	PF10026	DUF2268		Predicted Zn-dependent protease (DUF2268)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5504)	Family	This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.	23.60	23.60	23.60	23.60	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.09	0.71	-4.93	29	528	2012-10-03 04:41:15	2007-07-30 17:24:48	4	1	428	0	84	353	10	181.50	33	68.64	CHANGED	happhpcphpphtphapts.slslh.......lh.sstpp.hht.phGhpussuhsshlhlh..lssshsps.....clpullAHEaHHssRhphhphs.tshTLh-sllhEGLAEpastphaGcphhusWss.hspppLpphhpphlcpphchp...shtphsshLaGsthut........hPthhGYulGYplVppaLppsst.oltchshhsucpIlc	.........................................................................apphpp.hchhhs.hpt..sls.........lLl.uss.tp...hh.........p.h.sht.ussu.hsshlhlh...lssp.ols........phpullAHEhpHshRhp..h...............l..chp.....................s..hoLh-hllhEG....LAEpaspplaGc....tt.h..uPWso....ths..............p......ph.............hhcp...hltpplplp...thhchtsaL..a.G.....hsp..............hPph...hGYAhGY+lV+talppssh...sh.th.hsls.ApcIl....................................	0	26	58	68
+9859	PF10027	DUF2269		Predicted integral membrane protein (DUF2269)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5528)	Family	Members of this family of bacterial hypothetical integral membrane proteins have no known function.	27.80	27.80	27.80	27.80	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.06	0.71	-4.43	56	382	2012-10-01 21:57:53	2007-07-30 17:27:15	4	1	316	0	152	427	95	142.60	26	94.20	CHANGED	hlLKhLHlluuslLhGoGhGhAaahhhAp................................cotcstslAtss+hVVhuDal..FTssusllQPlTGhhLsals..GasL..spsWlhhSlsLYlluGshWLPVlh.lQh+hp...chApsAspssts.ls.tYhphh+hWhhhGhPAFh.uhlsIhaLMVsKP	...........h.hlchlHlluuslllGsshsh...A.hhh.h.h..Ap................................+su..s.s...ss..hu.t..s...t+h.ls.hschh.....h..h..ss..s.slh.PloGhhlsthh.....Gh....sl....sp..s..Wl....lhSl.sLasl.u.u.h.h.Wlsllh..hphcht..........chAtt..utt..tst.......ls.th.h..phhp..hhhhhuh....uh.h...shlslhhLMlhKP..............................................	0	36	81	113
+9860	PF10028	DUF2270		Predicted integral membrane protein (DUF2270)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5530)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	40.70	68.60	22.80	21.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.06	0.71	-4.81	19	87	2009-01-15 18:05:59	2007-07-30 17:27:43	4	1	68	0	51	93	11	180.30	40	77.60	CHANGED	uHLYRGElsRussWRoRLDpTTNWAVsssussLShuFuospus.hslLlshlhlhhFLhlEARRYRaa-laRuRlRhhEpsaaAshLsstths.css..WpphLApDhp+Ppa+lShhcAluRRLRRNYhaIhhlLhlAWhsKlslHPh.........stShsphlppAulGPlPGhhllsssshahhshlslul	.hHhYRGElsRhssWRsRLDpTTNWAlsshAAhLShuhSossssHhsLLhuhhllhlFLhlEARRYRaaDlaRuRVRhlEcsaaAthLss.tss.sss..WpphLup-hcpPphplohh-AluRRLRRsYhalhhlLLlAWlhKls..s............stshsphhpsAulG.slPGhhVhsslshaYsshlsls.h....	0	9	29	42
+9861	PF10029	DUF2271		Predicted periplasmic protein (DUF2271)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3656)	Domain	This domain, found in various hypothetical bacterial proteins and misannotated lysozyme proteins, it has no known function.	27.30	27.30	27.50	30.60	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.78	0.71	-4.68	62	357	2012-10-03 16:25:20	2007-07-30 17:27:59	4	5	342	0	130	295	47	138.00	31	75.56	CHANGED	Asshpl..slplsplsstpactPY.....VAlWlpsu.csphspTLtVWhpps........+Wh+-.lRpW..WR....csucptp..lDGloGAT+ss.Gphthshsssts.hssLhsGpYplhlEsuRE.sGscph.....hclshsl.....spststphpGpsElusl	...................thslslpl.pLssh.thctsY.....VAlalpcs.puphstoLhlhstps.................KWhcc...L+pW...aR....tsu..ts..sp...lD...GlTGAThsu.Gc...shch.shchscsLhsusYplhlEuAhE.ctscph.........sclshsL.....ssputshpspGpp.lus..............................................................	0	37	87	110
+9862	PF10030	DUF2272		Uncharacterized protein conserved in bacteria (DUF2272)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4322)	Domain	Members of this family of hypothetical bacterial proteins have no known function. However, given its similarity to the CHAP domain it seems likely that this is an enzyme involved in cleaving peptidoglycan.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.56	0.71	-4.82	13	136	2012-10-10 12:56:15	2007-07-30 17:28:21	4	5	128	0	47	156	22	179.70	29	62.05	CHANGED	EssshuhpplutYW...t-ussscshhsGs.su.....................asWSAAFISWVMRpAGlss.pF.hussHusYlssAh...psGhsshshhth-PssttPcPGDLlCssRGRsphlsasuhhssss......asuHCDIVVu....sDs..pplpsIGGNVpsSVuMcplsLscuGpLsss...............................sss+hsWhllL+s	....................................................t.hhhthsttYW......p.shht..hst.......h..h..s.....................sWSAAFISWVM+pA....G..lss...Fshu.ss.H.hpYlpsAh.......pss....p......sh.hhh-s..ss.htP.psGDLlChsRups....h...t.h.ss.h.tshs...........hstHCslVVu....scs...cplphIGGNV..t.soVs....hpphslspt...Gpl....................................shh.WhhlLc.............................................	0	8	32	40
+9863	PF10031	DUF2273		Small integral membrane protein (DUF2273)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5547)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.40	25.40	25.50	25.80	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.10	0.72	-4.35	33	978	2009-01-15 18:05:59	2007-07-31 08:34:00	4	1	886	0	111	282	4	49.80	39	73.55	CHANGED	p-hhppaph.llGullGhllAllhlohGFaKslllllhsslGhhlGhhl.cp	...........phhcpa+h.IIGuLlGLllAlLhlolGFaKTlllllLshlGlhlGhhl-......	0	47	72	97
+9864	PF10032	Pho88		Phosphate transport (Pho88)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4554)	Family	Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance [1][2][3][4].	25.00	25.00	25.60	33.50	21.50	24.50	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.15	0.71	-5.08	27	200	2009-01-15 18:05:59	2007-07-31 08:46:54	4	5	167	0	148	182	2	178.70	39	92.04	CHANGED	MsPtloNlhlhLlhMQlu++..lsh-D.PpllhhlRhhYlsspslhhslYhasph+IspKN.....DhTsLKYV-PusPhuutt.....cs+hssTTV+-YDlpplpph.h+uhhhGluMMuFMHlYhKYTNPLlhQSI.slKuAhEuNlV+IHlaGpPApG-..L+RPF...Ktssuhhuuhtt..upspoDKpol-sAEpsstu..GsKs-	......................hsPtlpNlhlhLshMQlu++..lsh-D.PsllhhlRshYlsopllhhslYhYlptpIspKp...........Dh.TsL...K.YVEPs.sh..uupp...............E.+hlsTT...Vp-YDhpplcph.l+u.hhGluM.MuhMHLYhKYTNPLllQSIhslKuAhEuNlVKIH.laGpPApGD..LcRPF...K..ts.suhhutht....t...stspoDKtul-tAEcshtuGhK...............................................	0	57	95	131
+9865	PF10033	ATG13		Autophagy-related protein 13	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4573)	Family	Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage [1][2][3].	25.00	25.00	26.90	25.50	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.60	0.70	-4.94	38	337	2009-01-15 18:05:59	2007-07-31 08:57:08	4	5	247	0	227	334	3	203.60	28	31.14	CHANGED	IppFahKuutlIlpSRl...............................hsspssst+sN+W...................FNlcl...p-psthp-pL+hW+s.tshtp...............hPPllIEsaLDhptLssspslhh.Dttsp.h.s.tu.......................sp..-llLERW.hl-hc.............sttttssstssphsplYKc....sllLFRSLashs+lLPAa+lp+ph..........ttt.......................slslthRlh.........sGp..h.stsp.sLopPl...hst.p...............phc...phpFsslpTshGpLplsVsYRssscF	..............................................................lp.FhhKssplIlpuRh.....................................................................t...s...spsss.s.psscW....................F..Nltl...c-h.st.h.pcph+thhs..tth.s............................hh.shslElhLcs......................................................................sctsphlLEpW.plchs..........................................pp..s.sp.phpsh.slY++...................hhlLhRSLhshsRlhPAa+lt+ct..............s.......................t.phslhaRlh...............up........s.hsp...................................shp....phphusltTshG.plslSlsYRhshtF.........................................	0	67	122	185
+9866	PF10034	Dpy19	DUF2211;	Q-cell neuroblast polarisation	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4587)	Family	Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants [1]. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.	20.40	20.40	21.20	20.70	18.80	20.30	hmmbuild  -o /dev/null HMM SEED	642	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.31	0.70	-6.35	12	344	2009-01-15 18:05:59	2007-07-31 08:58:36	4	6	92	0	200	352	2	453.40	30	90.58	CHANGED	Alhsuhlah.altplaEN-paFSpluplEREhuFRTEhGLYYSYYKsll.cAPSFhcGlahlhpDshTEYPpsINsLpRFNlYPEVlLAhhYRsatthhphh..................................-PshFYltslFhLpGlhhshhahhuhhLS.GShLuGllsshhah..FN+s-sTRl.aT.PLREsFuaPFlhhQhhllThhL+p...ptspptphlhlhhoshh...FhLsWQFuQFllhTQlhuLFshashuhlsss...Khppllhhhh.......hShhlsalLhF....GNsMlLsShhhS.llulhslhtl.................ppp...hsthhh...clhhhllpshhhhshTlhLphhhpplL............shpDDtHlhshlcuKa..tsapsFcohlYsC.usEFshlptcs.h+lspThLlshhlhhhshhh.............hphhtsh...........................................................................hthlsppp.p.....................pcsp.t.csE................................................................................llYpslQhlsFshLAllIhRLKhhhTPahClhuuL.lCSppl............a.........lhppl+ht.............ssshhllshhhhphhsslppphshlsEass.sp.pELlpWIppsTp.sAVFAGuMsshAsVKLoTtRslVNHPHYEcsslRcRTchVYphYS++ssc-V+cpL.hphtssYhIl-tshCsp.Rs+s....GCsh.-lhDhcsscstsp.............s.hCpt..lttc..s+......P...aFspVFp.NppYpVhKl	.....................................................................cpph.h.tc.uhYYsaac.hh....tu......sh.t..uh..lh.sp.o.........................................lNhlpph.lh.Elhhu....h.aphh.......t.h..............................................................pPh.FYl.hlahhtuhhh.hhahhu..........hhhS..so............h..............uGhlss..hhah..hN+h-sTRl.as.PLREsauhPahhhQhhhlThhl+........................t...h...........hh....h.h.hsshh...h.h.Wpaspahhhh.Qhhslahh..hsh......................ph..lhhh.h.......huhhhshhl.F.....N.hhL.o.h.s..h.hhhhhhh..........................................................................................p.............t..h.....ph.h......hh.h...hhhhhhslhlp.hhp.h.hh................htpp...+h..phlts+....h......htsFph.hh.hC.t.thth...th.....ph..po.lh.h.hhhhh..hhh.............h.hh..h...........................................................................................h.............................................st................................................................................................................hhaphhphhhhs.huh.h.th.Khhh..hshhChhuuh...ls.S.ph.................................................ht.ht............................h.hhhh..h.h..hph....sth.tph......htEa......s.sp..pLhpWIp.p..s.....t.s..............shuGs...hhusl+L.............s..................s.......hh.lsshPhYpptthht.Rs....h.Ythaupts.pplht.h..hthtspahllp..hC......t.............sCph....phhD.tp...s...t..tt..........................................hCt...h..t...........................F.hha..Nt.ahlhp..........................................	1	55	69	126
+9867	PF10035	DUF2179		Uncharacterized protein conserved in bacteria (DUF2179)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4843)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.38	0.72	-4.36	189	5446	2009-09-10 22:22:21	2007-07-31 08:59:57	4	5	1792	2	766	3177	158	54.80	32	19.63	CHANGED	RGlThl.pupGuYot....pc+plLhsVls+p-lhcL+pllpclDPpAFlsl.t-sp-VhG	...........RGlThl...pupGuYop......pc+pllhsVls.+.pEhscl+pllpplDPpAFlsl.t-spclhG............	0	297	555	661
+9868	PF10036	RLL		Putative carnitine deficiency-associated protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4380)	Family	This family of proteins conserved from nematodes to humans is of approximately 250 amino acids. It is purported to be carnitine deficiency-associated protein but this could not be confirmed. It carries a characteristic RLL sequence-motif. The function is unknown.	22.50	22.50	24.30	24.30	21.40	22.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.45	0.70	-4.95	15	168	2009-01-15 18:05:59	2007-07-31 09:07:27	4	4	123	0	110	159	3	220.70	42	95.44	CHANGED	hh+.RtLssLpas.tssthshs-cc-FtsllhWLEDQKIRhYphEDRppLRplssuc...WscsapKYhpDlphPh.........clps+pptlsWLLshAl+L-YtDss...............ts.pstpch.pcpp+psp.pscpsp..sslshssscFptGlppLAstLsltt..............................Hs........DplVhLcuss+llpE+Lspcstscsslp...s.Ph..-p.tslGhss................tDssLccAApILRLLpIpsLRcLQocINEslVuVQslTAsP+TDs+LG.KVGR	.......................................................................hc+KLpALsY....sshsh..p..DcpcFRshllWLEDQKIRtYpI....E-RssLRslpusc...WsphapK..YlpDlssPh............phpp+.p-tl-WLLuhAV+LEYsDss........................pphps....spptpss..sstspsspPl....sl.Dhs..s..s-F+sGVhsLAslLpIpp....................................Hs........Da..LlhLcA....lphl..lp-+Lstcu..lscssps.....ts.......h...shsh.c...c....t.lGFss............t.Dss.lspAApILRLLaIp-LR-LQTcINEsIVAVQslhA-PKTDp+LGKVGR..................................	1	42	52	82
+9869	PF10037	MRP-S27	MRP_S27; 	Mitochondrial 28S ribosomal protein S27	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4570)	Family	Members of this family of small ribosomal proteins possess one of three conserved blocks of sequence found in proteins that stimulate the dissociation of guanine nucleotides from G-proteins, leaving open the possibility that MRP-S27 might be a functional partner of GTP-binding ribosomal proteins [1].	25.90	25.90	25.90	26.10	25.80	25.60	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.47	0.70	-5.56	8	150	2012-10-11 20:01:01	2007-07-31 09:08:46	4	3	86	0	85	150	0	316.00	26	84.07	CHANGED	MtsShlppuhhhu+hh........uu+RhLLSuAYssuchWEuRcpEPhpLA.s...LAphh-psa-RKLPV....SSLsluRFlDNIuSR--..lDpAEYYLYKFRHSPNCWaLRDWTlHoWIRQCLcasupD+uLYTLcN+VQYGIFPDsFTFNLLlDsaIKcG-aKsAsSVVpElMLQEuF-hPSTphLSLYu.Lhpa...........LAspPsLo.......hpEERslGASLLlsGhKQ-solGhSup.LhGhALLGKVEhppGl+AVa+sMPLhWusGYLs+ulplhEtlAos..sltLuc-sLclhpslLc.....sLou.sDussptp.pcs.-sttpp.....plsEc...-psEpuK.......LspYucpFpch+spLpsts+l-scul.s.s.thlpE+LsssEp.DlchYEp+lptWphEpc...............pLIQREccpREpA-pE.....atstpss+su	..................................................................................................................................................t....tt..h....s.hslsh...h........ls.hpsp-c..l-.sc.hla........+..............aRppspshhltshsh.p.shlR.hLchst.p-pAl.hLpsplpYGlFsDsaoaNlLhD.hlcctpa.csAhpVlh.clh.Q-sh.ps........sTphLulhs.ha+h......................t...........p..............p-.hp..htsthlhs.hhpcp.shhp.p.lhGhshh..hhsp..h..t...s.ttlhpt...s.hht.shhtch.pshphhtt.......t.t.ltp-...slphh....tthhp..........th.......t.....t.....t..p......p..tt.t.t............p..pp...pp...hct..h............l.p.hp.apt...hppphpthhp.p.pth.......h.pph.thpt...th.tpp...h..c......................h.h.....tcpp.......p...p..................t......................................................................................................................................................................	0	20	25	52
+9870	PF10038	DUF2274		Protein of unknown function (DUF2274)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5639)	Family	Members of this family of hypothetical bacterial proteins have no known function.	23.80	23.80	24.00	25.20	21.60	23.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.00	0.72	-3.85	42	198	2009-01-15 18:05:59	2007-07-31 09:10:14	4	1	125	0	104	209	23	68.60	45	84.66	CHANGED	Mo+LKLGsls.D-+PVKlTlELPAslHRDLsAYAclLuppsGps..scPs+LIsPMLpRFhAoDRuF..sKAR+	..............sKL+LGsls.-ccPVKlTlplPAuL+....pDLstYAtlhup....p.hGps....s-sscLIs.MLcpFhAsDRuF..tKu+........	0	15	61	84
+9871	PF10039	DUF2275		Predicted integral membrane protein (DUF2275)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5660)	Family	This domain, found in various hypothetical bacterial proteins and in the RNA polymerase sigma factor, has no known function.	24.60	24.60	25.20	26.40	22.60	24.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.27	0.70	-4.44	7	40	2009-01-15 18:05:59	2007-07-31 09:10:48	4	4	40	0	13	40	0	204.20	22	55.95	CHANGED	.cpt..sDhhcphhu..tc.s..p.p..hh.thahphh+thultulhlhhhAsshhs.h..........hplsphslsplt.cshhslpsp..............hp.thhsls.tuhut...hpssut.uppssssslcplps.shhththsssh....sh.lttshsspppsht.h.ththhssthtshsts..............hhhsuchccptttlhhut..................shs.slpc+ts.cph.t..........st	............h.......DLscthhu..t..s..sspt.thh.thh..p+.hh+thAlhslslhhlAsss.h..h...........hplsshshshloscshtshpspa.............hpcsst.lshhshu....ltsGsh.utssuhsplsthhuhshhshhlsssh..............shpls.tshltsc.sh.hs..Lt.........hshlsthh+shutT.................hh..tphpph..hh...s............................................hs......................................................................................................................	0	4	9	12
+9872	PF10040	DUF2276		Uncharacterized conserved protein (DUF2276)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5551)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.00	25.00	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.53	0.71	-3.90	63	439	2012-10-01 21:23:39	2007-07-31 09:11:45	4	2	340	0	176	405	13	121.00	21	43.08	CHANGED	lpFhTPTthp..............cspthh..hPps.ttl.hpSlhc+asshss.hth..................stphht.hhspslplhshp.l....+shphph.........pttthsGhsGpssapht.......tthhpthttLlphupahGlGppsuhGhGpsc	......................................................................lpFhTPsth+p....................puphh.h..hPss..thl.h...poL..hp+a...sshss.hth....................s.phht..thspplpltshc..l....cs....hthth...........pttphsGhhGphsaphp.............htphhthLLthupasGlGtpsuhGhGth............	0	82	133	161
+9873	PF10041	DUF2277		Uncharacterized conserved protein (DUF2277)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5552)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	64.60	61.40	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.58	0.72	-4.02	22	232	2009-01-15 18:05:59	2007-07-31 09:12:33	4	2	229	0	100	209	12	79.60	55	87.30	CHANGED	MCRNI+sLhshEPP.....ATc-EIcAAALQaVRKlSGhscPSpANptAF-pAVt-IutsopcL.LsuL.sps......PP+sRtt.tA+	..MCRNIppLRs.hp.PP.....ATs-EIcAAALQYVRKVSGhp+PSs.ANpEAF-pAVs-VsssTp+L.LsuLss+t......PPhcR.t.tA+...............	0	31	70	87
+9874	PF10042	DUF2278		Uncharacterized conserved protein (DUF2278)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5634)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	27.50	28.80	19.10	22.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.45	0.70	-4.60	27	254	2009-01-15 18:05:59	2007-07-31 09:13:42	4	4	223	0	76	227	3	209.10	41	82.83	CHANGED	Msl...psYGVhKup.hphth-tttp..tsPHhplhlcssss...........................spaRsAlNlcSss......t.sucllYhhspph.p+Plhpp.LssLs.Gap.Lp...........................ssssthuLDYlRss.Lhsspsh+sls.hDhs...................GssNDlhchL-shlppuhtp.........................ssplYlFGph.............F......................psu.sG....lHslHMNQGss..p.......caps-NGlaQDGulllch.......sD..........pWsulFlAFtoQshhT.Ds...pGc	..............................MsL...psYGVLKGpslp.pht.....pst...toPHYpV+lpsp.ss...........................s-aRl.AINVcSps........h.sS-ll.Yhssp...sh...cp.shph.L..s..sLs.GaTclp...............................sspstsALDYlRus.....LaDspphhsLP..h-ts...................GscNDLs-hl-phlcpAhp.p.........................cuhlYsFGcp.............F.................................pPG...NG....IHDIHMNQGNs..p.......+apsDNGlWQDGulLlca......p-..............tp.W..hulFLAFpSQuasT.D-.pGp.............	0	20	34	53
+9875	PF10043	DUF2279		Predicted periplasmic lipoprotein (DUF2279)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5544)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	28.50	28.50	28.50	28.60	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.01	0.72	-3.71	20	603	2009-01-15 18:05:59	2007-07-31 09:14:20	4	1	591	0	71	238	32	86.00	69	70.70	CHANGED	usDsWsup...........D+ApHF........hsSAsLuAsusp.........tp.h.huhhhosulGhhKELaDoppuGSGaSapDLAhDhAGushGhslhpts	............A.NDuWSGQ...........DKAQHF........lASAMLSAAGNEYupH..QGhScDRSA.hFGLMFSlSLGASKELWDS.RP..EGSGWSWKDhAWDVAGAoTGYslWQh.s..........	0	14	34	52
+9876	PF10044	Ret_tiss		Retinal tissue protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4402)	Family	Rtp is a family of proteins of approximately 112 amino acids in length which is conserved from nematodes to humans. The proposed tertiary structure is of almost entirely alpha helix interrupted only by loops located at proline residues. Three sites in the protein sequence reveal two types of possible post-translation modification. A serine residue, at position 41, is a candidate for protein kinase C phosphorylation. Glycine residues at position 69 and 91 are probable sites for acetylation by covalent amide linkage of myristate via N-myristoyl transferase. Rtp is differentially expressed in the trout retina between parr and smolt developmental stages (smoltification). It is likely to be a house-keeping protein [1].	21.70	21.70	21.90	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.21	0.72	-3.45	7	126	2009-01-15 18:05:59	2007-07-31 09:14:58	4	3	87	0	79	121	0	89.70	44	69.00	CHANGED	LlShEpLDRuSP-lWPEphPGhsEFho.sts.h...pssPpahssLsc-DhshlpcLGsLosspLhtKlKpLps.AYQLGLcEA+EMTRGKaLsIhs	......................................LlShEpL..RsSP-lWPEp....h......PGls.-Fss.p.p.sshp..sssscahsc.l.c.....p.-Dl..c...hlpELusLTsssLh-Kl+sLpshAYQLGL-E............u..+EMTRGKaLsIhp.......	0	24	31	56
+9877	PF10045	DUF2280		Uncharacterized conserved protein (DUF2280)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5556)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.00	24.00	27.40	24.50	23.60	21.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.90	0.72	-4.11	15	135	2009-01-15 18:05:59	2007-07-31 09:15:31	4	3	102	0	25	104	1	99.90	48	65.70	CHANGED	MAsLss-VKuFIVQALACFDTPSpVscAVKcEFGlcloRQQsEoaDPTKtAG+sLuc+WtsLFccTRc+Fhp-sucIPIAN+AaRLRsLsRhupKAEph+NhuL	..........MAsLpppVKhFIVQuLACFDTPopVAcAV+pEFGlcloRQQVEsaDPTKsuG+sL.u+Kah-LFppTRccFppc.ltsIPIAN+AYRL+tLpRhhpcscp.+sh..h...........................	0	2	10	20
+9878	PF10046	BLOC1_2		Biogenesis of lysosome-related organelles complex-1 subunit 2 	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4559)	Family	Members of this family of proteins play a role in cellular proliferation, as well as in the biogenesis of specialized organelles of the endosomal-lysosomal system.	26.80	26.80	26.80	27.20	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.22	0.72	-3.86	17	169	2009-01-15 18:05:59	2007-07-31 09:16:01	4	4	142	0	123	176	6	95.60	35	58.97	CHANGED	hpchhsshsphlpuphptospchpLLEphNpssst+YtchpphspsLpsphcpLptp.pphpsalppIcpI-pplspLEpssptLDtasppLEsKlpsl	...........pchFschupalpuELsuosp-Yc..LLEpMNchsuh+Yh-hcslutslspslpcLsp.Ka.tpL.pPalpQIstI-cpVspLEpsshcLDsYoppLEs.KhKp.................	0	40	60	98
+9879	PF10047	DUF2281		Protein of unknown function (DUF2281)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5559)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.14	0.72	-3.68	19	250	2009-09-11 14:35:08	2007-07-31 09:17:16	4	5	143	0	89	275	17	56.90	21	71.76	CHANGED	sppplhpplppLPpclhpElLDas-FLhpKt..............h.pptsppthhhshtGt..h..pp.pshs.sslElQ+chh	.....................h..ttlhpplppL.PcphtpEVlDFl-FLhpKt.................t.t..................................................................................................	0	26	63	83
+9880	PF10048	DUF2282		Predicted integral membrane protein (DUF2282)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5572)	Family	Members of this family of hypothetical bacterial proteins and putative signal peptide proteins have no known function.	22.40	22.40	24.00	23.30	22.20	19.40	hmmbuild  --amino -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-9.04	0.72	-4.06	74	316	2009-01-15 18:05:59	2007-07-31 09:18:13	4	5	262	0	115	309	38	55.50	49	57.74	CHANGED	pEKCY......GV.uhAGpNDCuA.GsGToCAGTSpsDhQGsAWphVstGTC..........ppl............ttGoLp	..........hEKCY......GV.AhAGpNDCAs.....usuooCAGoSphDhQusAWphVPtGTCspl...............stGoh.t......................	1	22	60	95
+9881	PF10049	DUF2283		Protein of unknown function (DUF2283)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5428)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.80	20.80	20.80	21.40	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.33	0.72	-4.11	63	354	2009-01-15 18:05:59	2007-07-31 09:19:17	4	2	242	0	146	369	32	50.30	28	59.25	CHANGED	h+lpYDt-sDsLYlpl..spssht.......-ot-lss........slllDhDppGcllGIElLpAo	..............plpYD.-sDsLYlpl......psspht...........-op-lss...............slllDh......D.ppGcll.GIElhssp...............	0	47	102	126
+9882	PF10050	DUF2284		Predicted metal-binding protein (DUF2284)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5423)	Family	Members of this family of metal-binding hypothetical bacterial proteins have no known function.	25.00	25.00	28.30	27.60	22.00	21.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.38	0.71	-4.65	37	229	2009-01-15 18:05:59	2007-07-31 09:19:58	4	5	162	0	103	212	12	159.70	24	78.21	CHANGED	chthlpstclsl.pppsth+Cp..sCssYGpphsCPPtssshcEh+chlpcYcpAlLhphphsspp.tp.............................hhthppplpphhhclE+phhttGa.hAhshhsGsCp..hCp..p.......Cshpp..tt...........C+hPchsRsShEAhGl-lhphscps.sh.hphht.............pphshhuhlLl	........................h.stclhhptchhth.Cc...tCssYGpshuCP..Ph.ss.....ssc-htthlppYcpuhlhphp..h.hpst.............................t.hh.....ptp.hpphhhchEcp.h..h......t..p.u.a...shsh.hsG.sCp..hCp....c.......Cshtp..sts............CRaPccsRsSlEAhGlDltphscph.shph.hst...........phhshhuhlh....................................	0	56	88	95
+9883	PF10051	DUF2286		Uncharacterized protein conserved in archaea (DUF2286)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5399)	Family	Members of this family of hypothetical archaeal proteins have no known function.	24.00	24.00	24.30	107.50	23.40	18.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.63	0.71	-4.54	12	37	2009-01-15 18:05:59	2007-07-31 09:20:22	4	1	37	0	21	27	0	143.70	41	98.34	CHANGED	M..slVs+hccspVspc-VlcG-ls-lV+clAtchLc.EWsPpsSDFlllRDhhplphPhPL.p.ElhEcl..+paphp+scscs.lplPla.IsasspWh.tpsapsccshVVhPYlD-ptpcElhchshpshut.t............................cEEt.pc.E	...M.+llllKuEsGcVssccls-.G-lscVl+clAp-.ALc.EWN.hsSDFIIhRDs.ElclPLPL.pP-lYEtl..+pF....hht+scscA.hsclPVYhISa-NpWt.-ssapDc+laVVu.YIsD-hpcpllssAsphToppc............................pE..tc...-.p.........................	0	8	11	16
+9884	PF10052	DUF2288		Protein of unknown function (DUF2288)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5626)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	58.60	58.30	22.40	17.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.07	0.72	-4.27	36	217	2009-01-15 18:05:59	2007-07-31 09:20:50	4	1	217	\N	72	199	26	92.90	42	87.76	CHANGED	ssL+scLtt-TuplsWp-LpsaaARGsllhVsssLDLl-VAhulApDspspVppWlssGplu+sosppApcW.hpcs.phWAVVVuPWVLVQ-c	.....o.sLhs+LhuETApIsWs-Lp.FFA+GsLlhVstsLDLlpVAcAlApDDsppVspWLusGtlu+sssppAt-a.hscssp..LWAVVVuPWVLVQp....	0	18	41	59
+9885	PF10053	DUF2290		Uncharacterized conserved protein (DUF2290)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5619)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.10	34.90	24.30	23.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.49	0.71	-4.99	8	37	2009-01-15 18:05:59	2007-07-31 09:21:39	4	1	36	0	11	36	0	185.10	31	87.28	CHANGED	Lss-.Nhsshpp.s......ssscloasGtEcsulhht-hsYucl..YpulhcppuYshhLlDGuLlQhpYchcpspLlpHRLuYYPsPtLhs.............hps-s-lhhpDhLhh-hspctllshP....lRFDFDs..tttp...cssHPsSHlTlGsssuCRIPVsusLTPcpFlcFVlRNFYpoha+chlut.....hsstph-Fc....soIsspEpslhHls..hs	.............................................N.s..pp.s......th..lshss.tp.....pshpYpcl..YptlhcppsYshhL.hDGullQh.Ychp..p..spllpHRLuaaPuP.hlps.............aps-s-hYhpDhlhh-.....Ihpcpl....ls..hP....lRFDaDs..stht.......chtHPpSHLTlGphpsCRIPVsuPlTPphFlpFlL+pFYpothcsh.st.....hsphp...pFp.....olh..EtthhHhs..s.........................	0	4	7	9
+9886	PF10054	DUF2291		Predicted periplasmic lipoprotein (DUF2291)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5618)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.10	20.10	32.50	32.50	18.90	18.20	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.21	0.70	-5.04	21	215	2009-01-15 18:05:59	2007-07-31 09:27:20	4	2	195	4	58	151	13	196.30	36	91.75	CHANGED	sllhsAsslllLsthupcIl...h..up-ssutsus.tFsPcphusphW.sclhs.sppcAlshs-ltstlssstsuAsppYG...ht.ss..shhV+hoGsVsssc.....suthslclcGs.tpsslplQhGPslpGoulRDAsuhlpFs-F+NQI-asphupAlNspspspVlt.h.....scsslsG+plsVhGsasL..sssph...hlsPlplpl	.....................................s.h.shssllllshsGtclh......p.s.sDss.s......hs..s....s..hsPs.shusshW.scVhs...plppcAlshsEltstl..su..st..s..uAscpaG....st.sss.shsV+hoG.sVsphc.....uuhhsl.c.l-.G....t.hslplQhGPslpGTsLRD.AsshIpFs-F+NQlpasphupAlNpchtppVh..h.....ssp.shsGcsVsVlGsFsl..sssp.......lTPlpLp...	1	10	24	39
+9887	PF10055	DUF2292		Uncharacterized small protein (DUF2292)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5583)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.00	20.00	20.10	20.30	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.40	0.72	-7.45	0.72	-4.62	23	311	2009-01-15 18:05:59	2007-07-31 09:28:01	4	2	292	0	79	190	5	37.40	43	67.35	CHANGED	chlccIpchLcsl+aGSlTlslQDGpVlQI-+sEKlRL	..................l.ccIpshLpsh+....aGolpIsVpDGpVlQlE+sEKhRL........	0	27	55	67
+9888	PF10056	DUF2293		Uncharacterized conserved protein (DUF2293)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5586)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	26.40	25.40	24.90	23.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.98	0.72	-4.01	25	287	2009-01-15 18:05:59	2007-07-31 09:29:46	4	1	242	0	124	205	3	84.60	39	24.91	CHANGED	pAl+sLaPthPtpc......tcsIlpHAh.cu......utRVG+.sushs.tt.+VpLAVhAHlRHpaTcYD..pLLcsGhsRcpARptVhctspslLpcWt	.........................t.ulppLhPthPtsc......tpsIhp+Ah.cu........................pt+lut..sushs...t..tVpLAVsAHlRHhaTcYD..pLL..c.s.G.hs+csARthVhptlpshLscWR.............	0	26	68	98
+9889	PF10057	DUF2294		Uncharacterized conserved protein (DUF2294)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5609)	Family	Members of this family of hypothetical bacterial proteins have no known function.	21.40	21.40	21.60	22.00	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.25	0.71	-10.06	0.71	-4.44	23	741	2009-09-11 07:39:01	2007-07-31 09:30:33	4	4	437	0	101	280	9	110.00	38	92.03	CHANGED	Mppo.+stlEpEISculppacK-hlGRGstplKThIlcsMlllpLcGlLTssEptlspo...tcGhthlKpsRspLh-st..ppclpcllpclhGpcVhuhaoDloscTGEplhVFhL-.......pslEK	..............................hEtchschlpphcK-hhG+Gs.p.l.+osh.hcsMs.IssLpGlLTPsEhhlspT....p-Gh.hl+tsRo-.hlcps..ppphp.chlpclsGtKl..hshaoDlsspssEtl.lFhh-....cslE.........................................	0	46	70	88
+9890	PF10058	DUF2296		Predicted integral membrane metal-binding protein (DUF2296)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5415)	Family	This domain, found in various hypothetical bacterial and eukaryotic metal-binding proteins, has no known function.	21.70	21.70	21.70	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.81	0.72	-4.22	30	334	2009-01-15 18:05:59	2007-07-31 09:31:15	4	6	254	0	214	322	1	52.20	42	14.26	CHANGED	ahDRllDhLlGsss.......psRhALICppCptHNGhu...pcchp.l.papCspCsshN	....................hDRll-hLlG-ss.......psRaALI.CppCttHNGhAh...pc-hphl.ta+CshCthhN...........	0	60	110	171
+9892	PF10060	DUF2298		Uncharacterized membrane protein (DUF2298)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5427)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	24.70	24.70	25.00	24.70	23.00	24.60	hmmbuild  -o /dev/null HMM SEED	473	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.96	0.70	-5.65	18	117	2009-01-15 18:05:59	2007-07-31 09:33:29	4	9	68	0	64	119	65	412.70	21	56.82	CHANGED	lllsassahluhl...hsa.......sllls...slhlhshuhhh...hh+pc........h........t.hlts-hlFhsuFhFhlhlRsapPtl.h.....Gs..EKFMDauahsulhRusshPPpDsWFAGtpls.YYYhGaLlsulhuhLoulssphuaNLAlAshhAhsssuhaGlutslspth..............h.hhhhsshhshhh........ushhshh..h.................hthhushhhttssshsa................................................aWsuSRsl.ss.....................IsEFPhFoalhGDlHuHhlul...sFhlLsluhshshatptsppp..............................thhhlh...hulsLGhlhssNo.WDaPlah...sLshhslhhh.tt.h.h...................ph..hhs.............t.ssllslluhllhlPFhls..hpstuhtt.....hshl..............ppohh.phlhla.GhFhhhhh..uaLhsplppt............hhhhh..h.hh.......hhshslhulhhPllshuhhthhppp.................sssFhsLLlhsuhsllllsEllYlp-s.hss...sRMNTVF..KFYhplWllh	..............................................hhshhhahhs.h.....................hhhs....hh.hlh.shsh.hh.....hhptt...............................h.......ht.hh.h-..hlF.h..hhFhhhlhlRh.....hs...Psh.h............usE+.hDhuah....pulh+ushhPP.D.WauGt.ls.YYY.hGahhhuhhshlouhssthuaNLslshhhuhhhhssaulsht..lhtth................................................hhshh.h.shhh.........sh..hh..h........................................h.....h.h..h.....h.........................................hW....soRsl...s...................................IsEFPhFoalhuDhHsHhhsh......shhlh.hhshhh.th..h.hp.tttt..............................h.hhhh...hulhhGh.h.hhhNs.Wshshhh...hlh..h.h.slh.h.h.h.p..h.............................................................shhhhhhuhl.lhhPFhht..h.s.s..tt...............l.thh......................pto.h.phlhla.Ghhlhhhh.......hh.hhtthht..........................................................................hh......h..........h.h.h.hh.hhh....hhhhh......hhhhh..................................................t.hh.hl..hhhhuhhlhhhsEhhal.p-...................RhNTlFKhhhpsWhlh...........................	0	23	51	54
+9893	PF10061	DUF2299		Uncharacterized conserved protein (DUF2299)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5440)	Family	Members of this family of hypothetical bacterial proteins have no known function.	22.10	22.10	22.20	22.40	19.30	21.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.67	0.71	-4.73	13	64	2009-01-15 18:05:59	2007-07-31 09:35:12	4	1	45	4	34	53	58	135.50	29	87.04	CHANGED	cItsWhpELGhhlp+...sssusthFHlssoPPt.sssslsllRssscosaYlluhulslcspH.phl.thphccRpchltplph-Ll+h.sV-FhhhPPsp-.PpsIQlu+.latDG..LTKNchlssltpV+NuulhVl.hlp	..............................ltsWlpEhGhhspc...sssupthFHhssssPt..uGsslsVl+PpscschYlluhultlc.pH.ptl.thphc-Rt+...hltplph-LLch.sV-F.hhh....P..s.sp-.PpsIpVu+.la.tDG..LT...pNchlsslhpV+Nuslhll.hh............................	0	8	19	29
+9894	PF10062	DUF2300		Predicted secreted protein (DUF2300)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5445)	Family	This domain, found in various bacterial hypothetical and putative signal peptide proteins, has no known function.	25.00	25.00	26.00	35.30	24.30	22.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.88	0.71	-4.43	13	657	2009-01-15 18:05:59	2007-07-31 09:35:38	4	4	320	0	34	314	12	129.20	50	47.26	CHANGED	+uspssp......hhsspAstuhthDthLsp.....oluhahpPhthshsshshsphW.t+psPtWhtcLsshssappssshslsclhpshPhpDptRctlh........stslholtsRl.........slspphhahuFuuaPs	........GspspE.......hssQAGpu.phDphLsh.....ShuhahAPpp.phth.shuphW...t+....p.hPtWht.Lps.ps.s.pssVhulhc..lushPhps+..tQchLh...................Itsh.hLtsRl.........D.ppEhhphuFsGa....................................	0	5	13	24
+9895	PF10063	DUF2301		Uncharacterized integral membrane protein (DUF2301)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5413)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	31.00	29.50	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.73	0.71	-3.96	38	200	2009-01-15 18:05:59	2007-07-31 09:36:44	4	1	188	0	59	175	0	123.50	38	62.52	CHANGED	luLphIHIYl+sl+phLQhhWhlGsluh....hhh.h....t.h...lhspPh....hLulGshFsuLsGluFKEaFCFp+hEshhlshLlPlhlLupLhGlhshththuLlu..ulLhlllAlRKathPltsDIGDKSlFpa	................hshsslHIYl+sh+hllQhhhhlGllst........................lhs.hPh....LulGshFhsLsGlsFKEhFCFphhthph.shllshLhLualhshh.htthhullu.....ulLhllhAlpKaphPl+hDIGDKohaph.........	1	9	32	51
+9897	PF10065	DUF2303		Uncharacterized conserved protein (DUF2303)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5532)	Family	Members of this family of hypothetical bacterial proteins have no known function.	21.90	21.90	22.10	22.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.51	0.70	-5.53	14	390	2009-01-15 18:05:59	2007-07-31 09:38:46	4	2	323	0	29	229	15	251.50	51	98.85	CHANGED	M......s..coAlptlttshhsusphpp...uh..shl..hlP-...uh+lpsLEpahs......p.sRh+GshpspshsuFlpYspcptp..-ssphF..Ist-....shsssulhshtsts......s...........sGas-apAshshptTstapshhshsGcthsQtchu-alED.tsslls........hsssu.......................uchlplspshpAs+phshcuusptpsspspFshpcss.psscupp...hphPstFthphsPapshsphplphRlphhh..tsup.slhhcllp.-tl.EphspEhtshlpcthpst........lhlGohp	.....................................................p.D..usAlppIp.shloAtsssp.lsthts.ssl..sLP-....sacl..c..sL..E..+Fth......sRFRFRGshoTsSI-DFs+YS...KchAs........Eu.......oR...CF..IDAD..........sMcAsoVlNlGT.l.-.p.................PG...HADNsAoLcLK..+TAPFpALL.s.lNGc+.sQKsLAEWlEDWADaLlu...............aDus...................................G-slphocAsuAVRKITI-AspouDaE-sDFSGKRSlMESVEAKoKD..lMPsuFcF+ClPFEGLc.ER.s..FcLRLSllT....GDcPVLVLRIIQLEAVp.E-hAsEFRDLLlEKFc-scl.....ETFIGTFo............................	0	7	14	21
+9898	PF10066	DUF2304		Uncharacterized conserved protein (DUF2304)	COGs, Finn RD, Sammut SJ	anon	COGs (COG2456)	Family	Members of this family of hypothetical archaeal proteins have no known function.	23.00	23.00	23.00	25.20	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.43	0.71	-4.23	15	588	2009-09-10 17:25:32	2007-07-31 09:39:02	4	3	561	0	136	408	84	113.90	23	92.15	CHANGED	Mhh.lQlIuIllhlhsllhlhhph+csplshssslhWlhhalslllhslFP.plutpIAcllGlGRGlDsLhhluIhlhahLla+LYl+l-+LER-ITcLV+EIAIc..-t.p.hp+cc	................hphl.h.l.lhu.l.h...h.hhh.llpt.l+.+.sphphchulhWllhu...lshllhulaP.plhshlAphlGltps..sshlhhhslhhlhhh.hhphohplSchc..pclppLsQcl.Alh....pt.........pt...............	0	45	79	111
+9899	PF10067	DUF2306		Predicted membrane protein (DUF2306)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5395)	Family	Members of this family of hypothetical bacterial proteins have no known function.	29.10	29.10	29.20	29.70	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.51	0.72	-3.90	47	499	2012-10-01 23:59:14	2007-07-31 09:40:11	4	1	398	0	212	456	145	104.70	23	44.00	CHANGED	hptKssp....hHRhlG+lalshhl.lsAlouhaltth...thhu.....asshalLuhhhlhshhhulhss++tp.......lttH+thMltsYhhulsssshhsh.l..........ssRhhhsllhs	............Rp+thphHRhhG+lal.shhl..lsulou.h..h.lsh.h..s...hs.h.hs.....hhsh.tlL.u...lhhlhssh.hAlhsh+..ptp...............ltpHRpWMlRsahhshsss..shphh..h....................h.hhh............................................	0	79	141	186
+9901	PF10069	DICT	DUF2308;	Sensory domain found in DIguanylate Cyclases & Two-component systems	Anantharaman V	anon	Manual	Domain	DICT is a sensory domain found associated with GGDEF, EAL, HD-GYP STAS, and two component systems [1]. It assumes an alpha+beta fold  with a 4-stranded beta-sheet and might have a role in light response [1].	25.00	25.00	36.90	36.30	23.80	23.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.48	0.71	-4.61	93	183	2009-01-15 18:05:59	2007-07-31 09:43:40	4	11	104	0	87	191	1	125.80	24	28.34	CHANGED	hs.spushppLhpt.h.t...s..p.thahKsoLhALs+ulEDpllp......sp.pshlhuuFQptchappEs...cR.YpclAppup.plalhus................................................s-ssh......sssphhpshh....lsssDsLspEWaLllluss.....asuhllspEh	....................................t..........p.thh.KspLhulS+slEDpslp......ss.ps..llhusFQctphappcs...cRYpclAppss.plalhus................................................s-ssh......sspthpslt.....hsssDs.LspEWallllusp......asuhLlspE..............	0	18	66	86
+9902	PF10070	DUF2309		Uncharacterized protein conserved in bacteria (DUF2309)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3002)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.30	26.20	23.50	23.20	hmmbuild  -o /dev/null HMM SEED	788	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.47	0.70	-13.30	0.70	-6.43	67	634	2009-01-15 18:05:59	2007-07-31 09:44:26	4	4	569	0	133	484	108	793.90	40	94.76	CHANGED	hlcpAschIsPhWPLcsalAsNPahGhpcpsFtpsusphtpltGschhhspshappthtpGcIspssLptsltt........................................................................................ttshshshsphhtthtp.................................................tt..ttl........slu-hhsshp......u....hshsshlscplspasuuaaDpGQuhWp...Pt+cpGhYsAW+phsppDhshtht...t.tthtphltphPpssppulspslppL..slspsthpsYhcphLhsLsGWAuhhpapphps...th.sppp.tslh-hLAlRLsh-hsLh............................................................hht..htthht...............................thtspttpshhs.............ppshthstlhpcAhEtuapcpLhpsl..........................t.....ssssssst..............+P..th.QusFCIDVRSEshRRtLEshsPt....hcThGhAGFFGlPltapshussstcsphPsLLsPphtl...........t.s...ttpthpppp...chptphpptapphKpsslouFshVEssG.hauhcLltcoLts.............................ptssshh.php....t..................................................................................uhohp-plshAtshL+uMuLT...psFA.LVllsGHGSposNNPasuuL-CGACGGpsGtsNARllAtlLNcspVRpuLtpc.GIsIP-DThFlAAlHsTTTDclphastct.lsts...tpsshcplcshLspAuphsptERutpLs...tssp...........p.hpplpcRupDWuEsRPEWGLAsNAuFIluPRphTpuhsLcGRuFLHsYDWpp.Dp..cuslLEhIloAPhlVupWINLQYYuSTVsschaGSGsKlhHNVs.GslGVhpGNuGDLRsGLPhQSVcc.spphhHcPlRLhVlI-APt-tlpcllpcp.............ssl+pLh-NtWL	...............................................l.lppAp+lIsPl.PlstFsApNPa.GhEspsFcpsAphL+cltsscla.stuhhcpthtpGcIspsslpptlsphh................................................................................................................................hph.sptthphhhpshtp.............................................................................tshtt.sh..............shu-hl.spp.u.........pshs-.lscphh+WsthYhDpttusWs..hP..pR..-..p.uhYpAWhclspa...Dhuhsht..........+phlpsLPp.c..sp.slpps...Lspl..uIs.p.pphpsYlcupLLuLsGWAGhhhaRupQt.............pp-.thLpDaLAIRLshE.hLl..............................................................................tstht..hhtps.p...............................................................................................h......phssschpshhp............hhtphspthhcpLWlpAaEhsapppLhppl........................................tss...p.p..s.psss......ps...psQhAFCIDVRSEsFRRHLEshuP.....hETlGhAGFFGLPIphpslspphp+spLPVhl.sPsapl........................cphssc...phphh.pppp....pshpshhh.s.a.+..th..KpsshsohhLsEhoGsh.hulphlspolhP.............................cpsts..lp.phppphhpcs..p.sphplp...........p......................................................................................slGhT.pEplshAtpsL+hMuLT......csFAPlVVLsGHuSpSpNNPatAuL-CGACGGtoGuhNA+lLAhlsNcssVRpuLt.pp.GlhIP-cTlFhAA.HpToTDplphh.l.sc...Lsst....ttcuh-pLpshhstsuppAspERhspLs.htptt............pssp-spRhApDWSElRPEWGLApNAuFIIGpRpl.....TcshcL-GRsFLHsYDWcp.Dp-G..plLssIlouPslVApWINLQYYASTVsP+hYGSGNKsspsVs.uulGVhpGNuuDLhhGLsW.QSVhs.spphhHpPlRLhVVIpAPpthlpcllspp.............tphpchVpNpWl.....................................	0	43	87	115
+9903	PF10071	DUF2310		Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5595)	Family	Members of this family of proteobacterial zinc ribbon proteins are thought to bind to nucleic acids, however their exact function has not as yet been defined.	25.00	25.00	31.80	31.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.83	0.70	-5.42	23	268	2009-01-15 18:05:59	2007-07-31 09:45:21	4	2	257	0	54	193	9	249.40	52	99.43	CHANGED	MalsElpFc..sapssslsssp+sINpll-thRYNGQILGREaPlshspsp....FtsRllCPEpsSLtscaNSspVppALppLscsGllhsphcllGcDlNS-tos....cpppPoWQlLYTTalcoCSP.....L+sGDsltPIPLY+hs.sphsu..pcsllKWQp-WQACDpLQMsGus..hEphALcEIu-ssScLh++GhcLspcIEthTpIPTYYYLYR.VGGpSLtsEppRpCPpCGu.-WpLspPLaDlFcFKCDcCRLVSNLS..W-ap	............MYllELpF-..sassTolsus-+AINsLhDshRYNGQllGREFPlshu-s......FhVRllCPEp-SLaPcapSthVptslpcLs-suLltPph+llGpDlNSEpsA....Ep.-pPSWQlLYTTYlcoC..SP.....L+SG-sLhPIPLY+ps..sshsuD.acslIKWQp-WQACDpLQMsGus..sEpsALcEIs-scSsLF++GaDLptRIEhlTplPTYYYlYR.VGG....pSLspEpsR.CPpCGu.-WhLc-PL.....aDlFaF+C-sCRlVSNlSW-a.......	0	10	20	38
+9905	PF10073	DUF2312		Uncharacterized protein conserved in bacteria (DUF2312)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG3750)	Family	Members of this family of hypothetical bacterial proteins have no known function. Structural modelling suggests this domain may bind nucleic acids [1].	21.70	21.70	21.90	22.40	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.28	0.72	-4.62	51	455	2009-01-15 18:05:59	2007-07-31 09:47:06	4	3	340	0	158	352	153	73.20	50	78.91	CHANGED	lAu-pLRpaIERIERLEEEKKslu--IK-VYAEAKupGaDsKllRpllpL....RKpDps-+pEpEslL-lYhpALGM	...............As-pLRsaIERIERLEEEKKs........lu-DIK-VauEAKupGFDsKllRpIl+L....RKp-...ps...-htEpEul..L-lYhpALGM..................	0	44	91	109
+9906	PF10074	DUF2285		Uncharacterized conserved protein (DUF2285)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5419)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.00	23.00	23.30	23.30	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.46	0.72	-3.70	33	292	2009-01-15 18:05:59	2007-07-31 09:47:52	4	2	153	0	155	286	28	100.70	27	57.06	CHANGED	lhlPLcsshts....................RhcAhtRhhctLp.u+sssPssph..hsstp+tRhhphLpAlDuchsGAShR-IAtsLFGs..splstc..Wps..uulRsplpRLV+cGpuLhcGGYR+LLp	.................................................................................................t......ss.stt.....hss.pct+hlthL+sLDu....ptsGA.oaR-lA.p.slaGt..csspts...ats..sthRsph..cph..lc+upthhcuGYRpLLp.........	0	23	94	128
+9907	PF10075	PCI_Csn8		COP9 signalosome, subunit CSN8	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4414)	Family	This PCI_Csn8 domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome).  It functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development [1].	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.52	0.71	-4.42	48	621	2012-10-04 14:01:12	2007-07-31 09:48:56	4	7	256	1	376	1244	4	138.70	20	59.51	CHANGED	hhptphhu.hLlthLspsch.ssFchthchlPsshpps...................stplpplhpLtphLhpssYspha....phlcps....sp..phpshlssh..t-plRcclsphltpuY.....psIshpthuphLshs..sc.......phppasppp.GWpl..-........ssshhl.h.sc.ptpsps	............................................................hh....phhu.hLlhhL.h...p....h.ssFphh..hphl...s....t.....p..h..h.pt.......................................................................p..l...pplh.tL.tphL.ps.pas...pha....................p.h...css....................p.............sht..hl..s.sh.....p-sl...RcclsphlspuY............p.p.I.shsthsphLshs....sp................ph.ppa....s....pc...p...GWph..s...........ss.s.h.h..h......t.p..................................................	1	132	192	290
+9908	PF10076	DUF2313		Uncharacterized protein conserved in bacteria (DUF2313)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3778)	Family	Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins.	27.20	27.20	27.60	27.60	27.00	26.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.80	0.71	-4.88	60	660	2009-01-15 18:05:59	2007-07-31 09:49:48	4	5	514	0	114	541	6	159.10	22	80.70	CHANGED	ptLhphLPssht.sc.....hptlhpu.usplsplptpupsllpphhPpous..hLscWEchhGlss....ssst.olppRRptlhsKhptpGuhohthhtplApsh.Gh...slpIpphp....................hpahapVphs..........shsssscslps......lcshlcch+PAH....hsYs	.....................t..LhthLPsh.t.s.t.............hpth.hpuhu.phsplpppspplhpph.spTss....hlscWEchhGLss......sssp.olppRpptlhuKh....p..t.tGsh........ohtahhphhpsh.Gh...shplpphp........................................hpahhplphs............................shssss.sslpt..........lcshlpchpPuH.hhhh.Y.................................................................	0	38	77	97
+9909	PF10077	DUF2314		Uncharacterized protein conserved in bacteria (DUF2314)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3779)	Family	This domain is found in various bacterial hypothetical proteins, as well as putative ankyrin repeat proteins. The exact function of the domains comprising this family has not, as yet, been determined.	21.10	21.10	21.50	21.10	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.79	0.71	-4.10	10	385	2009-09-11 08:32:28	2007-07-31 09:50:18	4	9	337	0	61	293	6	114.60	27	42.17	CHANGED	DscMttAhs+ARpTF+aFWRELuW-pRRIlsuLDhAh.VKVsF.pD.t.....susssEaMWlsclsF..DGctlhGsLsN-PcploNlcp.GDplshsh--IuDWhalssG+saGuFTlsAMRupM.SccERscHDpAWGlDF	........................................................t......hh.pAppphthF..plh..pp.....h..hhh...VKlsa....-....................ptspsEHhWlp...hph..s.st.hhhGlLs.N-P...hhlpslc..Gpphplsh-.cIoDWh.hh.t.sst...............................................................................................	1	19	36	43
+9910	PF10078	DUF2316		Uncharacterized protein conserved in bacteria (DUF2316)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4367)	Domain	Members of this family of hypothetical bacterial proteins have no known function.	26.00	26.00	35.70	32.70	25.70	25.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.75	0.72	-3.99	7	273	2012-10-04 14:01:12	2007-07-31 09:50:44	4	2	268	0	23	100	1	91.20	54	95.69	CHANGED	MSLshtph+sT+pELptNFpLssLolpplAp-Lpho.sclEtlLpLc...........pplpDsWhLRsYL.ctlpppGppPhPaotLsG-....tpaWFLs	....MSLNKEQRRITsEELQAHFEtSTLSlphIAccLNlToE-VEKlLuMpsP.GlFuppLQRF.IHLVWDVRDlINDNIKtNGQTPcPYTYLKGEK...EDYWFLc.............	0	9	14	19
+9911	PF10079	DUF2317		Uncharacterized protein conserved in bacteria (DUF2317)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4365)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.20	24.20	25.10	24.70	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-12.61	0.70	-5.90	54	546	2009-01-15 18:05:59	2007-07-31 09:51:26	4	3	532	0	133	404	329	519.30	36	99.20	CHANGED	Mphcplsh.pp...sphhtDYhspppp....lpsFaph..h.p.psapcplsphppph...t...RpsLschLppphpphss.upts.psI-tLtp.pohsVlTGQQhGLFTGPLYolYKllSsIsLA+chcpph.shshVPVFWlAuEDHDa-ElNahhh.t.tt...+Khphp....t..cs.psussphsspslpphlcphhppl....spopasptlhphhpcs...........Y.tpssohs-uFttlhpcLFtchGLlllDusDspL+plttshhpctlpppsshtpslpppppplc.phGhs..lQspscplNLFahp..c.stRptlp..tcsspF..hlpsschpaoccELlchlcscPERFSPNVlhRPlhQEhlLPslAaIGGPGEIuYWupL+psFcthslphPhllPRhohsllpp+hp+hlp+h..........plshpclhhpth.......phhpcph.t.tppsslptshppt+p.......plpptappLtshstphDsohtshlptsptphhctl-tLEc+hh+utcR+pcphlpphpclpspLhPpsu.QERhhNhh.ah..scaG.pllsplhp.hpshtsp.phhlpl	.................................................Mchp.lslspp...sphlschhsuc........lpuhFpY.thhpp.puFccRhpc.sstc.......ctsLssslpcYhsc.....L.......p.h...o...ppp.tNIptL.sssohVVluGQQAGLFsGPLYThHKIhSlIpLuK-lp-ph.ptpVVPVFWIAGEDHDaDElNHTalhs.pptpl+Klpacshp....cs..osSchh.s..ptc.h+..phlcphFtphtE....TsaTpsllphhcch...........lcp.....hsoasDhFttLlpchF.....tsa.GllhlDuph.tLR+h..EsPhFKcllp+pptlpcuhcssQpphp.p.GhpshIpscss.lpLFhcp............-..s.RpLlp..h-stpF..hlpcsctsaoc-EllphhEppP.EpFSNNVVTRPLMpEalFsTlAFlGGPuEItYWuELKsVFchhslcMPhVhPRlplThlpc+lp+hLpch..........slshpclhh.s.s.l.......-t.+ppalppptspph.pchcthhc.......phpclapsLhp.ltt.psslp........hlpKNpphhhpQh-hL.++hhhslE+cp-lphcpFccIppsL+PhGu.QERlWNsh.hL..Nca.GhDhhc..h...PhsashpHhllp........................................	0	48	94	121
+9912	PF10080	DUF2318		Predicted membrane protein (DUF2318)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4393)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	25.40	36.20	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.04	0.72	-10.75	0.72	-4.25	36	409	2009-01-15 18:05:59	2007-07-31 09:51:54	4	3	396	0	77	306	8	104.00	46	25.67	CHANGED	plpDGKlH+ata.scsG+plRFFllpcsc...sphsssFDACplC..ucpGYh.pcGspllChsCss+hhlsoIG..psGGCNPlPl...saphcssplhIstssLpsGspaF	.......................lcDsKLHRFsY...lus-G....K....slRFFlIp+hs..tsuhsssFDAC.lC..GDtGYh.pcssplIChsCsV+lhlsolG..psG..GCNPIPl.....pachc.spcIsIstpsLtuGssaF.....	0	28	54	70
+9913	PF10081	Abhydrolase_9	DUF2319;	Alpha/beta-hydrolase family	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4425)	Family	This is a family of alpha/beta hydrolases which may function as lipases. This domain is the catalytic domain and includes the catalytic triad and the GXSXG sequence motif which is a characteristic of these enzymes [1].	26.00	26.00	51.00	35.40	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.74	0.70	-5.71	25	395	2009-01-15 18:05:59	2007-07-31 09:52:33	4	5	288	0	111	304	47	266.90	43	52.72	CHANGED	IRVYVGLsu.u-os-pRAcLAlcELcRsGAF-RpVLVlsssTGTGWl-PsuhcslEahasGDsAoVuhQYSYLsShLohLs-p-tuhcuAcALF-AVasaWppLPpspRP+LalaG.SLGAhuopsua..shhc.ltcs.hcGALWsGPPh.SphWpplsspRcsGSPthLPhacsGphVRF..ssp.sslst......sss.W.GthRllaLQauSDPlVaasscllaRcPDWlpEPtGs..........DVospl+WhPlVThlQlusDhssusssPsGHGHsYs.pcalDuWsAlssP.....pGWospctpRL+	...................IRlYAGLsu.........ucsh........pupAchsltELtRTGuacRpVllltssTGoGWlsthsssulEYhhpGDsAhluhQYSaLsShluFLsD+-ssppuucALFpsVhphhp.pLP.p.pRPKLhlhG.SLGSaGGpuuF......sslsshh.up............sDGAlasGsPh.sslWpplptpRc.GSPphlPlhssGcs.VRF..hsps...p.clpp...........s..sPW.sps..RllYlQHsSDPlsWWoPchlapcP.DWh+.E..t..G................DV.PphpWhPhVTFhQVo.ADMs....hAs..ssP...sGH....GHsYt.sphhshWAAVhs......ss.T..............................	0	26	81	99
+9914	PF10082	DUF2320		Uncharacterized protein conserved in bacteria (DUF2320)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5338)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.78	0.70	-5.74	39	519	2012-10-03 17:14:37	2007-07-31 09:53:37	4	6	416	0	193	493	51	322.80	18	73.62	CHANGED	cP.atshG.hhGuFhlpPulphussassNhhp.ssstpusshhplssclphpS-WsRHtlshchpushstatssp.................s..spsshsspssuRlDlscpsplshpsphphtpEspsussshts.s..ptP..l...hpshuushulppchschplsssushp+psYpssph.sus.shsspDRshsphshssRsuYclpPuhpsFsEsphspRhYD...phDpsG......hpRDSsuhtspsGsph-hophlpG-htlGYhp+sacDsphpsloGhshsAsltWpPpphTolphssspplp-o.sssssuuslppshslplcHphpppLsspuphsaspp-Y.psts.....RpDchh.sspsuhsYtl.sRhltlpsplcacppsSsh....sstsastsslhlulplph	............................................................................................................................................................t.............sh.lhPtlp.shthssNh....t....t.................s......p..........s.............t......p......ss.h...h...........thpstlthhsc.h.t.p...p.ph.p.lshph.phtpahssp..........................................p..s...sshth.phphp.h.....-h.s.p.p.p.p.l.sh.phphthtpp..stsps....................s....h.h.......s...................p..................psh..s..ht.hsht.p.p...s...h.h........p.h.p.hshs...hpc...hYts.......sp.....................................p......p.......p........shs..hththphhaph..sth.p..hhph.hsp..p.ac......s..s.............p+s..s...pth...hhhhG..hp.h.p..h.s..tt..hpu..phthG..a.pp....sa.c....s....s.....p....h........ts.h.............s.......uhs.hsstl..pWt..s.....hp.h.oshphhsppth...........pss.....s....s...............s............s..............sh...ht.....pthslsh..s+p....h.p...s.plshpht.....hshtp.csa..psss........................ppDpph..shshs..hsYth..pRhlsl.....phth.pappp.sSsh......sshsappshhhlshp...h...............................................................................................................	0	61	127	157
+9915	PF10083	DUF2321		Uncharacterized protein conserved in bacteria (DUF2321)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4306)	Family	Members of this family of hypothetical bacterial proteins have no known function.	22.90	22.90	23.40	25.80	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.02	0.71	-4.73	5	34	2009-01-15 18:05:59	2007-07-31 09:54:32	4	3	30	0	8	25	0	131.90	41	91.49	CHANGED	MGTYhsAQIChNGHphToussps.ELhpsFCs+CGutTIspCPcCsoPIRGcYYV-GVlulGp-Y-...sPoYC+NCGKsFPWTccuLEAAsELlE-s-sLSsDE+EpFpssLsDLllE..TP+TclussRFKKlluKhuououuulRDIlVDVASEolKKuI	............MshYchAplC.NGH.hssshsps.chhpsFCspsGttTIhpCPpCsssItGc....haV-GVhsh.u..tsap...sPoaCpsCGp.aPWscptltus.pllc.t.tpLss-EhpphppslscLhh-..s.P+TplAsh+aK+hhsKhtsssssuh+-IlVDVhSEssKKtl................	0	4	8	8
+9916	PF10084	DUF2322		Uncharacterized protein conserved in bacteria (DUF2322)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4390)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.70	20.70	20.70	23.00	20.30	16.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.29	0.72	-4.28	17	258	2009-01-15 18:05:59	2007-07-31 09:54:53	4	2	251	0	58	181	35	98.30	50	92.36	CHANGED	Fp-hLpsLPul-HLuulslhsupGplltpI.stsGphGSLpVYpALAppasu.lstsAApcGLElFAEHotDA+tpPGKHPNIDhLhpllpps.s.hplp.l	..................FpD.LApLPuIDHLuulclhDus.Gp.lVt.pI.shsGKhGSLplYptLA..ppFsu.LstpAAppGLthFA.EH.ssDA+spPGKHPNIDhLhpllpps.s.Lplcs.h...................	0	11	33	47
+9918	PF10086	DUF2324		Putative membrane peptidase family (DUF2324)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4377)	Family	This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family Pfam:PF02517, suggesting this family may be peptidases.	23.50	23.50	23.50	23.60	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.27	0.70	-5.15	28	607	2012-10-01 21:07:14	2007-07-31 09:56:08	4	2	500	0	78	421	23	198.90	38	86.09	CHANGED	lhhhlPlh..lhhah+..+....+htlsh+shhlGulsFhlhuh...lL.......Etslphhllp.stssthh...ppPhlaslYuuLsAGlFEEsGRaluh+aLh++ppthss................uluaGlGHGGlE.AlLlGslshlshlhht..hhspGphph.h........tthhttl.t.ltshsshphhLushERlhAlslpluLSllVhhul+..p+.+hh....alhhAIllHAlhDh.......sAlhQsth..hsthhssEsll	...........................................l...llshl......hhah+...K......+hplshts.hhlGslsFhl..sp....lL..............Ep.lHhhllpsptssshh...ppPhla.h...lYG.hhhAulFEEsuRh.lhF+aL.K+hp.tps........................................ulAYGlGHGGlE.hlhl.G.hhohls....hhlhh..sslpsts.p.h...................h.pth....chl.ph...sshphhLhuhERIhAlshQlhLolhV.htAV+...pK....Khh.......aLlhAh.hlHAhhDhh......suLhQsth....lss.hlsEsh..........................	0	16	34	51
+9919	PF10087	DUF2325		Uncharacterized protein conserved in bacteria (DUF2325)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4378)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.20	24.20	24.20	24.60	24.00	24.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-9.99	0.72	-4.16	68	671	2009-01-15 18:05:59	2007-07-31 09:57:41	4	4	610	0	191	488	34	92.50	23	49.82	CHANGED	slLllGG..cphsphcphlcc...hGsphhhH....pts.pcppt.lsspl.tsDhVllhTshluHsshppl+ctu++psh..shlhs+.puhs.sltptLpphts	................................sllllGu..cphsph+pllcc.....hGschhha......ptshsppp..lsspl.t.DhllhhTshluHsshppl+ptAK+psl..sllhs..+.pShs.sltptlpph.t.......................	0	70	142	167
+9920	PF10088	DUF2326		Uncharacterized protein conserved in bacteria (DUF2326)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5293)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.80	26.80	27.10	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.92	0.71	-4.55	36	203	2009-01-15 18:05:59	2007-07-31 09:58:16	4	2	190	0	45	195	8	132.60	23	26.30	CHANGED	plscplY..spsu.hlshpssppup...aphph.h.......ssstSpGpsptclhC..FDlulhh.stpcp.pt.cFLlHDu.la-slDs+phtphlpllpc.hp..hshQallTl.p-cLst.........phspcphll....lcL..s.spss+LFthph	.......................................t.h.pplh...ptts...hphp..sp.p.s.........ap...hph.h.......ssstupGhpphclhs..FDlslhths.tpp.pt.tFLlHDu.lh-slDscphtshlplh.pc.tp........hs...hQhIlol.pDclsp.t.............thp.pp.hl..............lcL.....sp.pspLFthp....................................................	0	15	36	40
+9922	PF10090	DUF2328		Uncharacterized protein conserved in bacteria (DUF2328)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5385)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.86	0.71	-5.09	59	265	2012-10-11 19:05:54	2007-07-31 09:59:00	4	1	263	0	96	302	75	177.00	35	84.94	CHANGED	VGAIsNGLELLs-sss....ptt..phsLlpcSupsAsARl+FhRlAFGAAGs.spplshs-spslhpshhpss.+.....hplsWpssss.hs+stV....+llLNhlllstsAlP+GGpl.pl......spsssthplpupGp+lplcsslhphLsGs...st.pslsupsVQhhhhhhlAppsGtplshphsssplhlss	......................................................VGAIsNGLE.LL--sus....sppt................AhsLI+pSAcs....A.o..ARLp....FsR.lAFGAAGo.....hG.....sp..ID....tu..-Ap....s.lspsah..p...s...p...+......splsWp..sscs....h.l....sKscV...........KLL...LNhlLlupsAlP.RG.GslsVt....h.s.sssss......p..ahlsupGphh..R...ls..schhchlsGs.....p..psl.cA.+sVQsaYs..hLLAccsG.hplslptss-plshs......................................................................	3	25	57	70
+9923	PF10091	Glycoamylase	DUF2329;	Putative glucoamylase	COGs, Finn RD, Sammut SJ	anon	COGs (COG5368)	Family	The structure of UniProt:Q5LIB7 has an alpha/alpha toroid fold and is similar structurally to a number of glucoamylases. Most of these structural homologues are glucoamylases, involved in breaking down complex sugars (e.g. starch). The biologically relevant state is likely to be monomeric. The putative active site is located at the centre of the toroid with a well defined large cavity.	20.90	20.90	24.20	23.60	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.59	0.70	-5.29	79	731	2012-10-03 02:33:51	2007-07-31 10:00:16	4	22	543	4	234	693	90	215.20	30	13.28	CHANGED	sah.hhsuEu+ls.hlAl......spucl.pptW.hthG...Rshsshstp..sLhoas.......GshFpahhshLhhc.hs.........ss.h.pss+tssthQhpY....utp.......huh.s.WGlSpSshss.shth.............YpAaGsP.hsh...........c-tVluPaAshhul.hs.PctuhtsLcpLh...t.shhG.......cYGFa-Ahsh.T.tt............t..shlscsahAhcQGhsllhlpNh.psshhhchFtssP	.......................................................................................................hhshhhsEuhls.hlAl..........spssl.pptW..h.....phG.....cth....ss.h..stp...tsLho.hu..................Gs.hFpahhshLhhc.hs...............ss..h.pss+tsshtQhpY....ut.p.......huh.s.WGlotSshss.s.t................................Yp.ua.Gs.Pths................cssVIuPaAulhuh.as.PptultslcpLt...t..shhG..........pYGFa-AhshT.............................................shlspsahAhcQGhhllhlpNh.psuhhhchFpssP...................	0	76	157	192
+9924	PF10092	DUF2330		Uncharacterized protein conserved in bacteria (DUF2330)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4402)	Family	Members of this family of hypothetical bacterial proteins have no known function.	18.70	18.70	21.40	19.40	17.20	17.20	hmmbuild  -o /dev/null --hand HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.13	0.70	-5.59	26	145	2009-01-15 18:05:59	2007-07-31 10:00:36	4	6	120	0	43	106	19	275.80	34	66.64	CHANGED	ssutAhCGhh...VusuDsplhssup.lllh+DG....pcTslsMp.sYpGc..s-cFAhVVPVPsl...spVplustclF-+l-phoAPRlschacp-sC............tt.t...sh..sssssuu.ussshG............lsV.schpVGtYElllLoup-usGLcsWLcpNGYplPsuApslLpPYlcpGhcFhssKlsssp.........suhspLcPLph+YcSschslPlRLuhlsA.......ssp...-lhlalLusp.RhpssNYppVtl..Nh.h.thhpp..p.h..Yttlhshsht...ssspAshTEYAhssussDPssh...shs.ptLtpLusssls..t.....................................................................................................................................hstpsaLTRLas+h.sspphsEDhhFp	..................................................................................shtshCGhh....Vsttssphh.stp.sllth.DG.......sppslsMp.shpu-......scs.hAh.VVPsPss...spVpsu-..t...phFscLDshoAPhl.c.h.c..s.p...........................t..sss.suustpssu.s..........spVhsphplGsh-sshLous-.sG....LpsW....L.s....c....NG.....Y..t.....l.........sussshLcPYl+pGhtFhsh+.lsssc.......................hhsssLcPlphsa.c..Ss+hhhPhRLuhhst.......psp.clhlahLoc+.R.phsshcssp..........................................................................................................................................................................................................................................................................................................................................................................	0	19	35	42
+9925	PF10093	DUF2331		Uncharacterized protein conserved in bacteria (DUF2331)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4394)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	82.20	80.90	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.27	0.70	-5.67	50	370	2009-01-15 18:05:59	2007-07-31 10:01:19	4	2	355	0	113	360	39	352.20	41	96.25	CHANGED	WDIFCpVVDNaGDIGVsWRLA+QLupEaGh.......pVRLWVDDLsuFs+lsPplcsshstQhhsGVplppWsssh..........shssuDVVIEAFAC-LPssalsuM..............stpspsPlWlNLEYLSAEsWV-sCHuLPSPpss.s...LpKaFFFPGFostTGGLL+...EssLhscRpuFpsssss+tshhppL.................G.....l.t.t....ssspllSLFuYEssuLsuLLctap...psspPlpLLVPpGRuhssl..t.....thhs...tshtsGsthp+GsLslplLPFssQpsYD+LLWuCDlNhVRGEDSFVRAQWAu+PFlWHIYPQ--DAHlsKL-AFLshYs.tslsstsssulpshapAWNsssssss.........Wtshtsths.....tlpp....+AppWstphhspsDLAspLlpFsps	....................................hDIFCpVlDNaGDIGVsWRLARpLsp.E.h.Gh.......pVRLWlDDlsuhtplsPshss...h..s.Qhh....pGlplppWpssh...........sshsssDVVIEAFAC-LPtsalpth...............tppptPlWlNLEYLSAE-WVpphHhhPSPpss.s...LpKaFFFPGFottTGG...LL+....EpsL..htpRps.a.pt.....s..ttppshhppl............G.....l........t.....ssshhlSLFuYcsss...lsshLcthp...........pu...s.......psstLLlstGphhssl...tp.h.hs...........t.htsGshhppusLplthLPFlsQpcaDcLLWssDhNhVRGEDSFVRAQWAu+..........PFlWHIYPQ--ssHLsKL-AFLst.hp...s.ths.......t.s..s....s....uhpphapsWNssts..s...........Wpshhpphs.....thpp....pApp.WsppLhsps.D..LuspLspFhp............................................................................	0	20	56	86
+9926	PF10094	DUF2332		Uncharacterized protein conserved in bacteria (DUF2332)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4427)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	25.50	25.40	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.11	0.70	-5.47	37	294	2009-01-15 18:05:59	2007-07-31 10:01:55	4	2	278	0	75	245	44	317.90	35	96.49	CHANGED	ltpsFppQActstphuSPhhucLhttlusphp.stshsupthhsatst..stupulPLRLhGuLHtLlLp.GpsstLsthYsst..pssstsh...sslppsltsapstlhshLcss.PQTNEVtRuAsLhsuhhhlupph.stPltLhElGuSAGLNLhhDRYtaphsss.p...h........GstsusltlsscWpGs...PP..hs...plspRtGhDLsPlDhsssssthpLpuYlWP-p.-RhtchcuAlulstp...ssp..l.cuDAh-hltptL...ttt.psshpllaHolshQYhPstpppthpstlpthGupAs.ppPLsalshE..spt..ssh.sttLp.......lchWssG....psphLucschHGpWlcWt	................................h..phhRp.uhhpspuuSshYptLshtlApD.-...shslhuth...........t.GpslP.hLhGulHhLl..Ls.G..+t..LtpaYsohs...p.........sspsh.........sthpchsppht-plhs.h.Lppt..sQTNEVtRsAhLhsuhthl.......hpph....ptPlsLlElGsSAGLpLhhDpYpYpY....s..ss..p.....a...........Gs.hsSsVp.l....sst..h...p...Gp......sP..hhp.......splVcRhGlDLpPhDlpss-chLhLpuhlWP-..pp.-.RlchhctAhuls+pt.......ssp.......LhcuDus.chLsshh....ttls...c-.AlhslaHohshp.lPt.ph.+ttlcttlptluAp....p..slh+Lh..............ss..cttl+.........................hcha.sG......htcslGcscsHGphhsWt...................................................	0	29	59	66
+9927	PF10095	DUF2333		Uncharacterized protein conserved in bacteria (DUF2333)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5345)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.40	20.40	20.90	20.60	18.50	20.30	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.97	0.70	-5.79	23	372	2009-01-15 18:05:59	2007-07-31 10:02:50	4	2	281	0	102	291	132	236.90	34	85.16	CHANGED	a........................tt...h+hlssshslhlllhhhlGhYWSpEPssFsVpspApptA..............ptpp.....pplVsGYTTTsTLIcls-TLLsKPGGYLSNDlhPPGLahDNMPuWEYGVLlQlRDLu+AhR+-FSRSQSQSsEDtDLshAEPpFNFDscSWhlPSoESEY+cGIctLppYhsRLs-sspssAQFYARADNLpsWLpcVppRLGSLSQRLSASVGpc+lNssLAG-ssu.ppuo.sssphtlKTsWhcIDDVFYEARGuuWALlHhL+AlEVDFuDVLcKKNApVSLpQIIRELEATQpolWSPhILNGSGFGlLANHSLVMANYISRANAAlIDLRpLLuQG	..............................................................................................psh....................................................................................................lsph.LL..K..Gha.ls.D.h.hP...a..hDNhsuaphGh..tlRchuhthhcshuR.pupSt.ct-LttAp.sp.h.......phsp......pu...Wh.......h.......P......p........s.u.YppulctLpta.scLt..........p..tpA.F.uRADNL.paltpltpcLG.ShSthLp................................................t......cssWhp..h..DshFa.uhGthaAh.thhpAhc.DFtpVLtcKph.s.shpph.+pLcss.t..hpP.hl.l.NG.s..s.u.h.h.ssH.hsMu.Yl.Rspusll-lpplLp.......................	0	26	55	78
+9928	PF10096	DUF2334		Uncharacterized protein conserved in bacteria (DUF2334)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5298)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.30	25.30	25.50	25.40	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.56	0.70	-4.95	40	444	2012-10-03 16:37:10	2007-07-31 10:03:24	4	6	384	0	94	382	96	229.30	23	48.78	CHANGED	pshlRlEDl.os.....h.ssh.cpL+pls-hlhcpslP..ahlusIPsahsspsth.........ltpssphlpsL+ahps+GGpIh.....LHGYTHph......hsthoG.shEhht........................................pp.thhtp+lpp.ulphhsp.sl.hsssac....uP+Yshoppsh.phhpphFshhhtphthttssh.......................................lpps....t.hhhPpslshl-tsp.............tp..pttphtptspsshsuhFaHsah....h......suhp..........Lpcllsth	..................................shlplcDVsP........h..tshsplctls-hLhc.p.s.lP..ahluslPsatssptth....................ht.t.phsphL+hht.s.cGusIh.....hHGYsHph.................t.su..hc....h...ht......................................sp.phhpp+.lpp.ulp.hsc..t.....pl...hP...huap....APpYthsppsh..ch.h.tph.hs..s.hh.tp...h.tpsh.........................................htp..........hhsp.sht.lp.pp..................t........ht.hthhp.ps..h.shahash..............tht.........l.p.ht..h...........................................................................................................	0	32	54	75
+9929	PF10097	DUF2335		Predicted membrane protein (DUF2335)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5346)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.70	26.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.14	0.72	-4.34	15	168	2009-01-15 18:05:59	2007-07-31 10:03:47	4	1	163	0	32	110	0	48.60	33	35.58	CHANGED	PsPslLpcY-pIlPGsA-RIlsMAE+EpcHRHch-ppt.......lctpp+cs+hGQ	..........PPPshLppYcpIhPusAc+lhpMAE+EQs..HRHphp.t............lc.ptp.s+hsp...............	0	10	16	23
+9930	PF10098	DUF2336		Uncharacterized protein conserved in bacteria (DUF2336)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5330)	Family	Members of this family of hypothetical bacterial proteins have no known function.	27.80	27.80	27.80	27.80	27.60	27.70	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.19	0.70	-5.15	75	459	2009-09-11 00:20:12	2007-07-31 10:04:31	4	4	166	0	204	448	45	213.00	19	64.39	CHANGED	VAtPlLppSshLsDsDLl-lspstu.psHhhAIApRtslotsVo-sLlctGstslltpLlpNsGAcloptuhppllcRutpssslttslstRs-LPsshhppLlstsucsl+pplht.ptt.hstpplppsh.....pcutspuss..thsststp.t.spthltpLcpsGc...Ls............suhlhphsppschs.hssAlutLuslshpplcplltcspsculhsLs+ssGLshsshtslhtthtthpph.sh.shpp.............hhspacpl.ssssApplLphh.......c	...............................................................................................................................................................lAtslLtpS..hLp-tsLlphhtpts..t.phhAlutR.tls..lssslhthst..sh..h...htN.tu..hs..sh..hhtt.tt........lt..hh.c.tls.thh..lh....hhs.ttht....t.h............t.htthh...........................tthtt....th...................t..t....h.tthlttlpt.ttp...hp.........................thlhphhhtt..pht.h.tulu.hsshs.thspthh.p.t.tslhhhhcthuhs.thh.hhhhhh....t....t.....thtt.............................h.t.htth...t.....h................................................................	0	59	108	138
+9931	PF10099	RskA	DUF2337;	Anti-sigma-K factor rskA	COGs, Finn RD, Sammut SJ	anon	COGs (COG5343)	Family	This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83 [1].	26.00	26.00	26.10	26.10	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.15	0.71	-4.53	90	784	2009-01-15 18:05:59	2007-07-31 10:05:33	4	6	638	0	335	801	62	181.70	20	72.39	CHANGED	PssplaspI...ptpltspst...........................t.hh...phth...Wpthuh......uusAsAsllslshhhs.............................................ssssshlAslsss.......sussshllphc.....psppl.lhshssssss.ss+shpLWhlsss..ssPhSLGllssssss.h..slssshtsthss....LAlolEP.GGSP.sutPTGsVlhpGtl	...........................................................................................................................Psstlhpp.l......ttlt.ttt...........................................................................................hhp..........phph..............W..+.hhs.h.......susAsusllssshhhh.................................................................................ttshs.sss.h.h.s.ss.hsst.............ssss..s..h...ll..h..h...s...........................pspt.....l...lh.....s.hsh.s.s......ss...sspshplWhl...............sst....ssPhShG.l.h.ss.ssss.h........hlshshhssht..........lulTlEP..tGGSs....pPT.ushlh.h.......................................................	0	106	225	294
+9932	PF10100	DUF2338		Uncharacterized protein conserved in bacteria (DUF2338)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4408)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	40.00	40.00	24.10	22.50	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.54	0.70	-6.12	6	271	2009-09-11 14:21:54	2007-07-31 10:06:33	4	1	260	0	13	118	0	418.70	62	99.03	CHANGED	hsplLllGoGPsAIQLAlshptHusscluhsuR..sSp+ScRla-AlsptsphhpVuhQNstHpphpGpssIDphaKchcslps-W-TllLuVTADuYhsVLpQlshcsLppVKslILlSPThGSshLVpphLsshsp.-uEVISFSTYhGDTRhlDcp.....................tPp+VLTTuVK++lYlGSo..cusSpplp+LstlhsplsIplpshsoPLcAEsRNlSLYVHPPLFMNDFSLpAIFpsppsPtYVYKLaPEGPIT.slI+cMtthWcEhMplLp+hslpslNLL+FMsDDNYPV+spolsRtDIEsFspLssI+QEYLLYVRYTALLIDPFSpPDEpG+YFDFSAVPa++VapscpulhcIPRMPpEDYYRlthIQulAptLslssPplDphLppYEsulppahDsptcpphSsuF.spsFcpDhslIsppl..psps	.........MSKlLMlGTGPVAIQLAslChL+uDacIDMVGRupoScKSKRLYQAYKK.-+pFEVKlQNEAHQaLEGKF-Is+LYKDVKsV+GEY-TVVhACTADAYYDsLQQLSLETLQuVKHVILISPTFGSpMlVcQFhSKhsp.DIEVISFSTYLGDTRIlDKE.....................sPN+VLTTGVKKKLYhGST....HSNSshspRIoALhEpLKIQLEVl-SPLHAETRNSSLYVHPPLFMNDFSLKAIFEG.TcVPVYVYKLFPEGPITMTLIREMRLMWKEMMsILpth+VPSVNLLpFMVKENYPVRPETLcEuDIE+FEhLPcIhQEYLLYVRYTAILIDPFSpPDEsG+YFDFSAVPFKpVYKNEQcVlpIPRMPSEDYYRTAMIQaIG+hLGlpTPMIDpFLsRYEuospuYpDhH.p-QpLSuQFssshFEtDtALVTKaLc...lNch..................	0	6	11	13
+9933	PF10101	DUF2339		Predicted membrane protein (DUF2339)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5373)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	29.50	29.50	30.70	29.50	28.50	29.30	hmmbuild  -o /dev/null HMM SEED	745	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.61	0.70	-13.65	0.70	-6.25	47	995	2009-01-15 18:05:59	2007-07-31 10:08:10	4	4	648	0	278	982	83	443.90	16	80.54	CHANGED	lutNhhlplGhlsLhlGssFLl+Yuh-psh..ls.thRlshuhlsGluLlusG.hLRc+............t.shhuhsLpGGGhuslaholhu..AhphYpllssssAF.slhsllsshsssLAlhppu.hLAslGllGGassPlll.SoGsushhsLauYhsllshuhhuluhh+tWchLshhuhshohhhhhhhh....h..ht....h.hssspshhhlaah..lalh.lslhhs..hptt.th.........................hs...ssLlhussllshsLththsp............hhuh.u.lhhuhlhhsls.hhlh+p..thphhhhshs.......................................hlslulsFssLulsluh.ssphpsh.......hWAlpushh........th...........s..lhllsuhhhhhs....................p..hhsshh...lshsshsusahhhthpttttttt................hhhhhuhhhhhhu..hhhtlppt.....................hhhhhsh.shhhhhhh....h..hth.hhhh.shhhh.h................hhh.h...............hth.hhsa..........shshhhhhhhhhhhtt...............................thhhhhhh.hhh.shhhhhth...........shhpthlhshhhhshhhhhh....................h...........shhhhhhh.lhh.hhhhhhhts.hhhs.....slshhPlhN.L.l.hhh.shshlhhhhtp...............hhthshhshhuhhsh..lhlsh.lt+hhpt.thh....................htt.h....phuaSlhWhlhulshhhhuhp...+p.pchlhhsGhuLlulsllKlFllDhuslsslhRllSFlulGllLLsluhhYpphhs	....................................................hhhh.hhhuh..hh.h..t.....hs..h+h.hhhh.u.hhhhhu....h................................................h.s....h..uhuh..h.hh.hhh......h.......h..........h.....h.s..........h..hh.hh..hhuh....t..hs..h.s.....h.s........s..hh....................h..a..hh..h...h.............h...h.........h....h.....................................................................h.h.........h..h........................................................................................................hh...........................................hh..h.h.h.hhh.........t..............................................................h.hh.hhh.h..h.h..h.h.h........................................hh....h.shhh...........................................h.....h..h.....h.h.h........................................................h.............hhhhhhh...hhh..h.................................................................hh.hh..h.h.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.shhh.hh.uh..hhhhhu.....................hh..h....h......uhhhhhhshhKhhhh-h.t...h.+hh.ahhhG..hhhhu........h....................................................	0	90	179	227
+9934	PF10102	DUF2341		Domain of unknown function (DUF2341)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5306)	Family	Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.	23.40	23.40	23.50	23.50	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.15	0.72	-3.83	55	186	2009-01-15 18:05:59	2007-07-31 10:12:46	4	24	122	0	107	186	82	87.20	28	12.34	CHANGED	scsuDlRFh....sssssp.LsYWlEphcs.....ssp.pAhlWV+lsth.......ssssIhlYYGNssAsssususss......F..hFDsFps...............shaphspssusss	...........suuDlRFs......sscpss..LsaalEpacs......tss..hAllWV+lPpl.s........spsslahYYG..N.s.....s.Ass..s..u..supss..........................FDs.ps................haphstt....s................................	0	33	58	85
+9935	PF10103	DUF2342		Uncharacterised conserved protein (DUF2342)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5282)	Family	Members of this family of bacterial hypothetical and uncharacterised proteins have no known function.	25.00	25.00	30.50	27.60	21.90	24.50	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.82	0.70	-5.48	44	734	2009-01-15 18:05:59	2007-07-31 10:13:14	4	2	468	1	237	622	191	326.50	32	80.26	CHANGED	V.sWcl.AtphApphs..us.......ssssspsststltpuschA-hhlcssTsLsssss......psplhsRscWlcsshssapplscPlspphspthts.....................................hhstluGthhGsQlGtsLuhLuscVLuphDhslshs...............ssGphhLVssNlsphtctLsls.c-hRlalsl+EssHpt.FsusPWLpsalhstlcpaupslshD..s....splpchscphp.s...sspphpph......tuhhcs.postQ+tALsRLpslhuLlEGas-hVhsssssthlPususlpcphccRRt.suGPs-phhtpLlGL-h+.+phccutshhctVsspsGhcstssVWscPDhLPsss-l-sPtsal	..........................................VsashAtphApphs....us.............s...sss.....sttttstltcAschA-halcssTtl.....sssss.....................pstshsRspWlcsshssappls......sPlspp..hstshss.hs.t..............................................hhpthuuhhhGsQlGpuLu.LusplluphDhulsls.............................ssuphsLlssNltshtpsL.clssp-htlalsl+EsAHpp.FstVPWLtsplhutlptaupshplDh.............stlc-hhpphss..............sPp...t.h......pphhp...............tsl.hpshpTstQ.ctALpRL-sLhuLlEGas-tVhstsssshlPusstlpEthcRRRA..su......GP...s.......EphhtsLlGL-h+s+ph+-ussha.ctlspt.....h......GhcutstlWscPDhLPsss-l-sPttal..................	0	72	179	222
+9936	PF10104	Brr6_like_C_C	DUF2343; 	Di-sulfide bridge nucleocytoplasmic transport domain	COGs, KOGS, Finn RD, Sammut SJ, Coggill PC	anon	COGs (COG5085), KOGs (KOG4503)	Family	Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport [1]. Brr6 in yeast is an essential integral membrane protein of the NE-ER, wit two predicted transmembrane domains, and is a dosage suppressor of Apq12, Pfam:PF12716 [2].	25.00	25.00	31.90	31.00	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.86	0.71	-4.65	41	216	2009-12-22 12:56:39	2007-07-31 10:13:49	4	3	159	0	165	210	0	130.40	30	33.73	CHANGED	lstYLQLhhNhllhslllallhthhpsl+pDlpp+hcppptplhtEhppCpcpYhpNpC.s....spp.lPAL-ptCppWccCM......sp...Dsphh.spsph.oAcslucIlNuFlcsloaKohlhllhhhhhhlhssNhshG.hR	............ttYlQLhhNhhlsslhlallht.hlhsl+pDlppphcptptclhtEhstCpcpYhpNcC..ts...spc.lPAL-phCspWccCM......sp.....DPstl...tpsp...h.oAchlA-IlNuFl-slSaKohh....hlhhhlhshhhsoNhshu.hR..............	0	49	97	145
+9937	PF10105	DUF2344		Uncharacterized protein conserved in bacteria (DUF2344)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5011)	Family	This domain, found in various hypothetical bacterial proteins and Radical Sam domain proteins, has no known function.	28.90	28.90	29.30	29.60	28.20	28.40	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.99	0.71	-4.80	74	639	2009-09-14 16:02:11	2007-07-31 10:14:24	4	5	634	0	218	549	66	181.20	28	45.89	CHANGED	RlRl+auKpGph+alSHLDlhRhh-RAlRRuslPluaStGFpP+P+lohAsALslGspSpuEahDl-L....pp..sls.scphhppLstsLPtGlcllpsppl........hpssulsshlssupYplpl...........ss.pphpp..tlcphlstcpl.hp+p.s.K+G+p......phDlRstlhplplpstt...............h.l.h.thhpsssssl+P	.................................+lRl+asKpGph+FlSHLDhhRhFpRAlRRAplPluaSp.G.Fs.PHP+lSa.AsALslGssSpuEYh..-lpL................p.c....sh.s.s...p.....c.......lhppLspt.hPs.Glcllcstch........tptssh.ts...hlsuupYtlph.......................ths.tphtp....tlps.hhst.c.p.l.l.p+to......K.pGp+.............phDl+shl.hp.lphtttp....................l.h....................................................................................	0	113	185	210
+9938	PF10106	DUF2345		Uncharacterized protein conserved in bacteria (DUF2345)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4253)	Family	Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.	25.50	25.50	25.50	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.78	0.71	-4.62	93	1108	2009-01-15 18:05:59	2007-07-31 10:15:10	4	20	365	0	273	1206	46	145.80	28	19.47	CHANGED	usssssssth.thspPhllluuPAGIuhsTspohphsAupp.lslsuGpsspluuGpshhssuucslSLFA...........ppsGl+LhAupGplplQAp.s-slplhApcslplsS......spsclplsAppclhLsuGGu.al+lp.uGsIphssPGphplKuAs+shsGPsu	..........................................................................t.....ttthsthtpshllhuuPtGluhsosps....h..phsA.upp..lthsuG.pshsl.ussps.hhhssu.pslolFu......................pptG.......l+lhAu.pG.......plplQAQ.s-.shpl.hA.pcs..lplsS.................s.psclpl...s.Apcc.IhLsuGGu.aIpl.p..susIphsss.GphhhKuuth.h.Gst..................................	0	26	89	172
+9939	PF10107	Endonuc_Holl		Endonuclease related to archaeal Holliday junction resolvase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4741)	Family	This domain is found in various predicted bacterial endonucleases which are distantly related to archaeal Holliday junction resolvases.	19.40	19.40	19.50	72.80	19.00	19.30	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.79	0.71	-4.53	15	76	2012-10-11 20:44:46	2007-07-31 10:32:13	4	2	76	0	29	67	31	142.10	41	87.63	CHANGED	lLllsIlsLhhphhplptch-p+tpphacpWpp..tt............ct....ct-sthppWppccEcclR+-uVp+S+uVltG+loEQLsPaF..P-FcYsPpDARFLGoPVDaIVFcGLo-......G.shpcIVFVEVKTGKsupLocRE+tlR-sI-sG+VpaEll+hc	............................................................................................pphhuclch.+pptltpspKcuVspSRAVLpG+huEQhAPhL..PEFpY.PoDA+FlGsPVDaIlFDGho-.......u.cshpIlhl-VKSG.supLocsppuItpAIccG+VRaEslRl....	0	11	19	26
+9940	PF10108	DNA_pol_B_exo2	Exon_PolB;	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	COGs, Finn RD, Sammut SJ	anon	COGs (COG3298)	Family	This domain is found in various prokaryotic 3'-5' exonucleases and hypothetical proteins.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.51	0.70	-4.80	36	607	2012-10-03 01:22:09	2007-07-31 10:32:51	4	3	575	0	155	1077	343	200.10	36	78.28	CHANGED	s-FL.hhhH+lVuISsl.hc.....ctspF.+Vhsl...us.sts......EpEllppFachlc..chp.PpLVSaNGpuFDLPVLcYRAlhaulsAspaa-tG-........hKWN..NYhsRYpsc.HhDLhDlLutat.spAsssLDplAslhGhPGKhGhcGupVhchapsGclpc......I+cYCEoDVlNTYLlYLRaphhcGplot-sYtpplphlpshL..ppp....s.......ps.+..hptFLpsW	..........................................................-Fh.h..ha+IluIuslhhp..................s.spF....+Vts.l..........st....p..s............................Ecpllp...pF....a....ph....l-..........ca..p....P...p.....L.V..S.aNGpsFDhPlLhhR.....A..L......h.a...s.....l..s....As..p...a.a-.h.sp.........................................K.WN......NY.h.s..R....a......p..p....p.........H........hDL.....h-....h..L..u.....h.......a...t.......sp..t....shsLD..sl..s.p..h..hG..l...P...G...K.....h...s...hcGs....pV....h..c.h.a.h......p...s..c...lc.c.........I.c.sYCEoDVlNT..Yhl...aL+aplh+Gt.lstcp.Y...lt.hpphL...tp..pts..aht.ahts...............................................................................................	0	53	109	133
+9941	PF10109	FluMu_gp41		Mu-like prophage FluMu protein gp41	COGs, Finn RD, Sammut SJ, Bateman A	anon	Jackhmmer:Q1GH51.1(1-98)	Family	Members of this family of prokaryotic proteins include various gp41 proteins and related sequences [1].	25.00	25.00	25.10	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.72	0.72	-4.06	114	1089	2009-01-15 18:05:59	2007-07-31 10:35:28	4	3	785	0	169	674	13	81.60	26	78.61	CHANGED	slpL.ppP...hph.sG...pp.....l...splsl.RcPpstDhcshp.........t.sp....ssc....tp.....htl....luplsu..ls.c-lppLshsDasplptthsshht	......................lpLppP...lptst....pp.........l...spl..sL...+cP..s.stsl+usp..........................shts........-ss....th.............hpl......lsplos...lstp-l..sphch.sDhtsltttlhsFh.h..........................	0	32	80	130
+9942	PF10110	GPDPase_memb		Membrane domain of glycerophosphoryl diester phosphodiesterase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4781)	Family	Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.	28.90	28.90	28.90	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.67	0.71	-4.78	31	1075	2009-09-11 03:27:55	2007-07-31 10:36:16	4	4	932	0	95	639	6	147.50	28	26.66	CHANGED	llYhpFuhLllshhplhtpp.ho....hcplhpp.shpplpplpssshlahlhYhlLllPFu..slshposLLsKlpIPpFI....h-alhpshhh.hlhhhlhhllhhalulRLlasLPlhllppp.sh+pAl+pSWphT+p.phhphlhhhlllhhhlsh.l	......................................llahphuhLlhh.shthh.pcp.hhp....h+plh+p.shth.l++.lhshph.lahhhYh.h.....lllPhh..shhhp.os..llspIhIPpFI......hs..L...hc.shhh...hl.....shhhhhlll........h.....YlslRLlF.s.LP.hhllccp.shpcAh+hShphTK+....pha+llhhhlhlhhhlh..hh.......................................	0	31	64	77
+9943	PF10111	Glyco_tranf_2_2	GlycosTransf;	Glycosyltransferase like family 2	COGs, Finn RD, Sammut SJ	anon	COGs (COG4092)	Family	Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis [1][2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.65	0.70	-5.32	12	436	2012-10-03 05:28:31	2007-07-31 10:37:56	4	22	388	0	82	19422	6862	205.20	17	53.59	CHANGED	SlIIPlthutt...l.c+l...Ltptpph..s.shpllls-ssssh...ppltplhsp.tth.hlpppstpphhu.utsRNtusphu....pochlhFhDlDshhs.shhpphlp.....tlpps.sthhhlPshYLsppuspthhp..t.h.cpthhcshhs.ttshht........hu..o.ushlhp+chFltlGGaDEsFhGaGhEDhEhhhR...Lthhthth..scshhh.chtphshh.........pGFRtaFthhuhshh...thhhh.HhaHppsptpsYh..pppttNcthh.pph+.h	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...............h......................t...........u....h.........h...p...N.........h....u...h.....t.........s...................p.s..p....h.....l.h..h.h..D....s....D...h....h.......p.......p......h...t...p...hhp.................................h.t.....t....t...............................h........h....h.......h................h........h..........h..............s......t...........................t........s..........p......................h......h.......p.................................................................t................................h....................p........p.....h......h.....t...................t.......h...h.t.........................................................hh..s........h......o.....u.......s.....h......h.....h..p....+.p.pa.....h....p.....l......G...........G.......a...-..E...s...a............h....s......a.....G.......h.......E...D.h...D..h..h..h..R.........L..h.t..h..s...h.......h........................................................................................................................................................................................h........................................................................................................................................................................	0	28	53	67
+9944	PF10112	Halogen_Hydrol		5-bromo-4-chloroindolyl phosphate hydrolysis protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4915)	Family	Members of this family of prokaryotic proteins mediate the hydrolysis of 5-bromo-4-chloroindolyl phosphate bonds.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.96	0.71	-4.91	20	680	2009-01-15 18:05:59	2007-07-31 10:38:18	4	3	601	0	75	370	10	187.00	27	78.74	CHANGED	M+hhhphll.hshlGhshhslshhsshhuhs.sFll.uhlluhuuhhssahsspphspt+.............alccpGLocc-YcYl+psLcEA+pKIppLpKshhpl+slpshcpsp-lh+lu+pIaptl+p-Pp+FacscpFaYp+LDslV-LoEKYshLsppPhKst-hppsLccTRhTlccLscslppDLpclls-Dl-sLDhEl-lAK	.................................................................................................................................................................hu..hhhlh.hhhhh.............h.....sh.l..hhs.h.hh.h..h..h..h......h.pphtptK....................................ahpphGLo.cp.-.h..c.h...h+pplscs.+...pplptlpcshs.ph+sl+......s....h.c.plschhplu+uI..a.pplcpcP.pph.hcscpFhYs+lssslcLs-pYscltc..pshK.spphpppLcp.o.ctslDplpcsltsDhccLhp-Dh-cLDhEhclsK................	0	24	48	61
+9945	PF10113	Fibrillarin_2		Fibrillarin-like archaeal protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4018)	Family	Members of this family of proteins include archaeal fibrillarin homologs.	25.00	25.00	534.40	534.20	18.10	17.60	hmmbuild  -o /dev/null HMM SEED	505	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.56	0.70	-6.16	5	30	2009-01-15 18:05:59	2007-07-31 10:39:21	4	1	29	0	19	29	1	505.70	56	99.96	CHANGED	M+DLI+EAlNDLDAAhEL+KLhhp.......tEpslpEVVDAVsDLScEEtpKLGusFRRFPLGCDLlEIuVGPCASDLohsslLuNClLADpMGhPIHVCAYAlADIAEsaGM+PIELh+EVhENVEVPLDLDHFGRYGPMRFP+-ITuCtGsCYhEGPPFKGCPR-RIH+RLIDKE+EtusDhEEWlKLASSVCVNVTsEQG..A-sHAAPL-EMc-VAEsARKaGKGVEAIhHVGDGYDDLIoGlKAul.DlcVDVFVlEGGPFNRAcDRLcAFA+AVAluRILVPGKVVATNGAYEDECRVGLRAGLNuILTGFP+NHHGYMCGYSPGTARRGpFGLPRVL+IMKEEl.uc.slTtsPlsK-pLEALARAs+FLGsN...hVYPpcIGshYlGDAHW.AuLssoslac+s+lsKTV--l....tst.suDTVALLGGRFlSWuIAcKLDtl.V-EllISDsDPWVE+ATV+lLs-ELcsslaussGDD+KAlEpADsSlITTsIPpIut+IupKhsDAlT..Ll	M+-LIK-AlN.DhDuAhELpKh..........t-pDllElVDAVsDLShE-h.KLGusF++FPLGCDLsElsVGsCASsLsLhplltNClLoDhhGhPIHlCAYAlADIAE+cGhpPlEVM+cVh-sV-VPLDLDHFG+aGPMRFPK-ITtChG-CYhpGPPacGCPR-RIHKRLI-KEKEtusEh--WlKLSSoVsVNlspEQG..uEsHAAPL-Ehc-VAchA+KaGKGlEuIhalGDGYDDLIoGlcAsl.DlsVDVFVlEGGPFNRAKDRLcAFAKAVAsSRILV.GtVVATNGAYEDECRlGLRSGLNsIloGFPtNHHGYMCGYoPGTARRGNFGLPRVh+IhKEEl.ts.slshs.lsK-.LcALApusKFLshp....IYPp.pIGsaalGDAHW.sslpsSslYcplp..lsKTl--l....tpt..ss-KVulLGGRalSWuIAccLc...s-ElhISDsDPWVE+sTV+lLs-s.shssassNGsD+cAhcpADpolIoohIPpIshKIpsKh..-Ahsl.........	0	5	9	15
+9946	PF10114	PocR	Hist_Kin_Sens;	Sensory domain found in PocR	COGs, Finn RD, Sammut SJ, Anantharaman V	anon	COGs (COG4936)	Domain	PocR, a ligand binding domain, has a novel variant of the PAS-like Fold [1][2]. Evidence suggests that it binds small hydrocarbon  derivatives such as 1,3-propanediol [1]. 	20.70	20.70	20.70	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.01	0.71	-5.11	71	805	2012-10-04 01:10:46	2007-07-31 10:40:04	4	113	595	0	236	604	20	166.20	26	39.32	CHANGED	lp-l.lDlptlQpl.-sFschs.tlshsllD.hcGpsl..tss..sapchC.chhRspspspcpChcSDtphu.puht...G.c.tlY+C.+sGlhDhAsPIhlsGpalGslhsGQhhhccps.-h.hhpptup.chGhsccp...altAhccVPhloccplpsshphhhplushluphuhpplphtp	.....................................................................hls.chlpcltpsFupuT.slAhll.....Vc...hc.........Gp.........l...o..chs.......sa..s.sFC..phh..Rp..ps....p...tp.p.p.Cpp...s.Dtp.u.G.hc...As+..............ss...pP.hI.Y+C.HsG.Ls.DhulPlll.ss.p.hlGhl.ls...GQVh.h...p.s..s..sc.......t..h........h...p..h.........s........c........s....h.ptc........hhpt..hpplPhhshp.cltssuphLthlsp..hhptthp......t.........................................................	1	116	193	212
+9947	PF10115	HlyU		Transcriptional activator HlyU	COGs, Finn RD, Sammut SJ	anon	COGs (COG5453)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. One of the sequences in this family corresponds to the transcriptional activator HlyU, indicating a possible similar role in other members.	21.30	21.30	21.30	21.40	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.09	0.72	-4.15	31	240	2009-01-15 18:05:59	2007-07-31 10:40:28	4	1	238	0	48	133	8	92.50	49	97.45	CHANGED	M...uhhs+LF....Guuptst.......pscP....-YcGFhIhspPhpEuGQaRlAupIpKcl.sGEh.KsHcFIRuDllsoc--Ap-hsl+KA+hhIDQpG-plF	................MuhhsRLF.......Guspt.sEss........psEPh.....EYKGFhIhspPhu.EuGQaRVAG+IoK.pI..sGEl..KsHRFIRuDlhs.ucpDAt-.lhL+Kup.hIDp.GspIF..........	0	9	23	33
+9948	PF10116	Host_attach		Protein required for attachment to host cells	COGs, Finn RD, Sammut SJ	anon	COGs (COG5622)	Family	Members of this family of bacterial proteins are required for the attachment of the bacterium to host cells [1][2].	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.28	0.71	-3.95	79	395	2009-01-15 18:05:59	2007-07-31 10:41:06	4	4	363	0	166	378	47	128.90	23	82.09	CHANGED	sallVADup+Aplhpspus.....tt.s.h.tltph.c.psp.tsp-lss.....D.psGc.hpstst..t..............ut.tps-h+phpccpFAcplAshLpc..ttppsch.ccLlllAsPphLGtLRppLppplpptl.hsElsKDLTp.t.....ssp-lpptl	..........................................hllVsDuppAhlhpstst.........th...h...ht...ph.p.pt...p.t..spphsss.psGp..t................................sh.tpss.....pchp..ccpFA+plAcpLpc..t.spp.tca.cc.LlllAsPp....hLGtlRppLsptlp.phl.ht-lsKDLsp.h.shpclpctl........................................	0	49	98	125
+9949	PF10117	McrBC		McrBC 5-methylcytosine restriction system component	COGs, Finn RD, Sammut SJ	anon	COGs (COG4268)	Family	Members of this family of bacterial proteins modify the specificity of mcrB restriction by expanding the range of modified sequences restricted [1][2].	20.90	20.90	21.10	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-5.51	40	909	2012-10-11 20:44:46	2007-07-31 10:41:42	4	2	849	0	160	671	83	298.40	25	74.67	CHANGED	l........+spsYVGhlphsss......plEILPK..hsppss................................................+phLhpMLp...........hstslp.hppsshsslpptch.sLhElhhhh..Flptlppll++Glhp-Yhphp-spphl+G+Lplsppl+pss..sppc+htscaD.Fs.Dps.NRll+suLchltphs............psssshc..hlpcltshh....p-lshsp.stpshpphp..hsRhhscYcslhthsclILpp..psshstpGcp.pshuLLFsMpplFEpYVu....thL+................tplssshplcsQsssha.Lssc.pspth......FpL+PDl..llpppspt...............................hllDTKWKhlps.....tpphu..lupu.DhYQhhAYuptYpssput......LlYP	...............................................................................................................................................................................................................................htshhGhlt.h....t..t........lpl.s+hs..t..........................................................................p.hL.hhhLp...........................................h..hshh...hp.h...s.p..h.ss..h..tppc...pLhp.lh.hhh...F.ctl.pt.hl+..+G...Lh+-Yh..php.cs...s.h.l+Gclplp.pp.l.+p..sh..shp..tp.h..t..sphcEaohDsshNpll+ps.l.phlh.ppp...........................p.sp.pphp........plhc.l.h.ha................pt.l.s...h.h...p......h..p...ts..h.....sphh........hpphh....ppYctl.hphshhlLpt......tp..s...h..t...t..up...p......c.....h..h...u....h....L......F...s...hpt....LaEcaVh...........phLp...................thh..t.s..p....p.s..p...s.p...s...t..sha......hlsp......................h..plp..PDh....hh..c..p.p..t....................................lllDsK.a..Kthp...............spps...lsps..DL.aQlhuYsht......hpttps...........LlaP.......................................................................	0	51	99	130
+9950	PF10118	Metal_hydrol		Predicted metal-dependent hydrolase	COGs, Finn RD, Sammut SJ	anon	COGs (COG3687)	Family	Members of this family of proteins comprise various bacterial transition metal-dependent hydrolases.	30.00	30.00	30.10	34.80	27.30	29.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-12.03	0.70	-4.93	54	983	2009-01-15 18:05:59	2007-07-31 10:42:16	4	4	332	0	205	849	96	251.60	30	85.30	CHANGED	lpsRclcF-hss..hs..taWhss-PhsTphhNuLSlhhPtGEpaFlcul+phpstl.....pDscLpp-lcuFIuQEAhHu+pHpthNp..tl.ptpGhs.lpt.h-thhphhhphhtc................hs.htpLAhssAlEHaTAlluchlLp.p.phh.tusDPphtcLacWHuhEEsEHKuVAaDlattlsu......pYhhRstshhhsohhhhhhhhtssth..hlppD.........tthhp.h+.shhcsh..phhh.u.t........Ghhp..thhsshl.sYac..PuFHPhpc....ss	....................sRclcFshss....hs..hpW.h.ss.sshhTHhhs.sLShlFPsGEcaFlcosRphp...spI.....pD.s....p.L+pclpuFIGQEAhHo+tHpthNcth..pptGhs...sct....hc....phth...hh...hp.hhpc..............hhshhhpLuhssAlEHaTAh....luchlLs...s.ph............tssDsp.htsLahWHuhEEsEHKuVAaDVaptltu.........sYhhRhtshlh.shs....hhh.sh.hh.h.hshh....hhppD..........tthhp..hc..shhchh..phhh....t...........uh.hp...thhtphh.sYh+..PsFHPtpps.t........................................................................	0	53	112	163
+9951	PF10119	MethyTransf_Reg		Predicted methyltransferase regulatory domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4797)	Family	Members of this family of domains are found in various prokaryotic methyltransferases, where they regulate the activity of the methyltransferase domain.	25.50	25.50	26.60	28.10	22.80	25.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.75	0.72	-3.49	20	365	2009-01-15 18:05:59	2007-07-31 10:42:41	4	17	288	0	96	333	26	85.60	31	15.60	CHANGED	ppsctYLhHEYLpthNpPhYat-FssphuptsLpYlu-ushtcshsthhhspst..pthltthscshhp..EQahDFhssRpFRpoLls+	......................tsctYltHEYlpt.NsshYapcFhcph.pcpp....LsYluDsslpsp.a.sshhsp.pst..pph..lptss.cshhp...EpYhDFlssRpFRpoLls+.....................	0	29	55	72
+9952	PF10120	Aldolase_2	MethylPyrKinase;	Putative aldolase	COGs, Finn RD, Sammut SJ	anon	COGs (COG1992)	Family	Members of this family of archaeal and bacterial proteins are likely to be aldolases.	25.00	25.00	27.20	49.10	22.70	23.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.86	0.71	-4.88	52	250	2012-10-03 06:25:16	2007-07-31 10:43:11	4	10	148	6	156	245	49	164.60	30	46.24	CHANGED	cplpcAlphltppst.hspLIPEVtoNluhuls...A+shpDVAulsGR.Isphts+stssusspFGuSpHlARllLsshchsschRuslNl+Ysccllcth....cchGhclsph-RppEPppsp.....oh.ahlcpshcph..sphPDl..IaDpGshGKEPhlhlhGcssh-Vlcplhpl	..........................................plcpAlph.l.tptpt.hhtLIPEVtoNluhuhs...AcshpDVAulsGR.Ih.p........h.tspshssusspFGuSpHlA+hlLsshchsPpl.RushNl+Ysccllcth....cp.hGhplsphccpp-Pppsp.....sh.ahlcpsh........pph..........sp..............sPDl..lh-pGshGpEPh.lhlhGcssh-Vlc+lhp.............................	0	38	83	123
+9954	PF10122	Mu-like_Com		Mu-like prophage protein Com	COGs, Finn RD, Sammut SJ	anon	COGs (COG4416)	Family	Members of this family of proteins comprise the translational regulator of mom [1][2].	22.90	22.90	22.90	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.96	0.72	-4.91	6	135	2009-01-15 18:05:59	2007-07-31 10:43:53	4	2	114	0	27	112	2	45.50	40	68.66	CHANGED	Mh+slRCGHCpKLLARhsshspLpIKCPRCtTLNHV+AsShp.p.Pp.p.pc	.........+slRCspCsKLLu+h......s.shs...plpIKCPRCtslNp.................pt.................	0	10	15	22
+9955	PF10123	Mu-like_Pro		Mu-like prophage I protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4388)	Family	Members of this family of proteins comprise various viral Mu-like prophage I proteins.	21.90	21.90	22.10	22.40	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.02	0.70	-4.98	21	423	2009-01-15 18:05:59	2007-07-31 10:44:10	4	6	304	0	68	385	21	247.10	23	86.85	CHANGED	lpLlPtGpFpupDGRs.p......ssWhlssssuttllsphs...ttttclsIDYEHQTlh.ttppGpPA...PAAGW..lcplpaRssc...GLa.ucVcWTscAtphIcscEY+YlSPVFhaDpssGplhplhsAALTNpPuLssht..tlsAlss...............t.s..pcpp.sphlctLhthLGLsssuss-t..............hh...........sthsssttsshsshtsshsthsttptphsshss..t..........sDhupalPlsshptl.......psclssLpsphsshph....-thlssAlp-G+lhPup.+sWuppLuppss..suLpsalssssslsALsupQT....h.sssststsusLos--hulsctLGlot--ahK	...............................................h.P....G......h....s.....pu..p...........h.hs..t.htth.h.ttht...t......t...sl.h.lDa-Hpshh.........st.s.......sA.u.GW....hp..t..h.hpts......u.l.h.sp.s.c...as.pu.tthltstpatalSsl.h....h...st.t........G...th....h......p.....lh.........sAL..TNp..Psl.th.......lh..shtt..................................t..t..p.....p..hpt.lhthh.s....l....ssstt..............................hh.................t..t........t.t.....t........t.......t.........................................................................s.t.hh..h.t....t.h.pt.l..........ttph...t...shp...t...p....t...ttth..........pthlptAhppG+.l.h..u.....ctah.thstp.....tthpshl..pt.t......s..shst.p......................t.....................................................................................................	0	22	44	57
+9956	PF10124	Mu-like_gpT		Mu-like prophage major head subunit gpT	COGs, Finn RD, Sammut SJ	anon	COGs (COG4397)	Family	Members of this family of proteins comprise various caudoviral prophage proteins, including the Mu-like prophage major head subunit gpT.	20.10	20.10	20.30	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.92	0.70	-5.44	23	696	2009-01-15 18:05:59	2007-07-31 10:44:45	4	10	447	0	86	552	204	140.20	27	35.41	CHANGED	LpuLhsuFpssFpcGls.tAsopasplAhhVPSootsssYGWLGphPphREWl.GcRllpslpuaGYsIpNKsFEoTVuVsRsDIEDDplGlYuPlhpEhGcuAutaPDELlFuLLKsGFoThCYDGQsFFDTDHPV.spssGTsssVusss.............ussGssWFLLDsSRslKPlIaQpR+thpFsshscss.D-pVFhpscahYGVDuRsNVGFGFWQhAauSKp.sLsusNatuAhpAMpuh+uDuG+.LGI.....+PopLVVPPsLEpsAccllps-...hssuGu..o......Nsa+s.sscllVsPaL	................................................................................................................................................................................................................................................................................................................................pt..hs..htsh.tAhphMt.h.p....t.-.st+......LsI.....pPs..hllVPsuhEshApp.llput......htsus..............Nshps.hhplls.s..th.............................	2	32	59	73
+9957	PF10125	NADHdeh_related		NADH dehydrogenase I, subunit N related protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4078)	Family	This family comprises a set of NADH dehydrogenase I, subunit N related proteins found in archaea. Their exact function, has not, as yet, been determined.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.20	0.70	-5.18	8	32	2012-10-02 00:39:38	2007-07-31 10:44:57	4	1	32	0	21	166	53	219.20	57	99.39	CHANGED	Mh...o..IuGplLslIPFGDIVhYhSsaohlhFlsAlhFTlllhlo+PE+QlEhpaGp.u.+hcpVsscEhRh+RFMAIlCGlATsGAhlTGDlFNFoLFlAlIGIsNIGIV.oAV+pcaVLsAAFpYGllAMlATLPLFGGAAlILAsTGTLSIaELuth...uts.hllauKlLLslGVlGEsGlAPFYAAKAEhFRAPGAPYILMIHLSSLLlhlRslEILLol	.................................................................h....tsluGphhGhlPhGDIVhYhTsFollhFlsAllFThllhloKPE+QlEAphtchGs+hphVshc.EhKIRRF...MA..I...l...C..GlA.T.A..GA.M.l.TGDLFsFsLF..lAlIGIsNIGIV..SAV......K.p.c.a.VLNAAFpYGlIAMlu.oLPLFGuAAllLApTGTLS...laELu.ph........sss.....llat.K...l...Lh.slGhh..G.EoGlAPFY..AAKAEMFR.APGuPYI.LMIHLSSLLlIlRslEILLol................................................................	0	5	11	17
+9958	PF10126	Nit_Regul_Hom		Uncharacterized protein, homolog of nitrogen regulatory protein PII	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4075)	Domain	This domain, found in various hypothetical archaeal proteins, has no known function. It is distantly similar to the nitrogen regulatory protein PII.	22.90	22.90	22.90	74.90	22.30	22.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.23	0.72	-4.29	6	33	2012-10-01 21:59:08	2007-07-31 10:45:06	4	1	25	0	24	32	0	108.20	47	95.18	CHANGED	M...........................................+lhl+LFVEsENlGKshNhLo-sGITGFYlhEY+GhSPscWKGFplc..EDPEhAIchlpDhSccAVlIsTVVsEEplc+IcchlcE+Lss-RYTlIclPlppIcVsts	.....MKlLl+LFVEs-NlGKAINALoEuGITGFaLhEY+GMSPp-W+GFhlp..EDPEhAlcllp-hSpsAVlIsTVVsc-pltcIcchlcE+Lps-+YTllElPlhsIpVNt...	0	5	10	18
+9959	PF10127	Nuc-transf		Predicted nucleotidyltransferase	COGs, Finn RD, Sammut SJ	anon	COGs (COG3541)	Domain	Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.	21.10	21.10	21.10	21.30	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.69	0.70	-5.03	47	840	2012-10-02 22:47:23	2007-07-31 10:45:28	4	4	657	0	203	769	31	217.10	25	84.92	CHANGED	M+ppl.pcLpclEpcp....sl.........+lLaAsESGSRAWGFsSs..DSDYDV..RFlYlcsh-aYlul.......p.t..+DVIEhslscpLD.lsGW-L+KsLpLht+uNPsllEWLpSPll..YhpssshhpplpthspchFsscpshaHYluhAppsh+pa....Lpsc..pl+..........hKKYhYlLRPlLuspWlpptts.hPPhpattLhtth...ssslhsclspLLshKpputE.hphhst..hshlcsalcpp...lcphpphspt.pp........schptLsphhhc	............................................................................h.th.tp........th...........pllauspSGSRuaGhso.......-SD...h..Dl....Rh.lal.ps.h.cha.l.pl..................................pt.....c-sl....E...h...s...h...s...c...p......hD..lssa-l+KhlpLhtpuNPsllEhL.tSPhh....h..p..p..t.p..h..ht...th..h.th..s....thF...s.pts..h.h+Y...huhAp..pph+ph..............hpsp.....ts+......................................................hK+hhalL.Rs.llssphl.ttt....s....h......Ph...................t.........hhtphp.....tLLthKptt.p.ht..........h.....lp...t.....hlptp.......ht.ht......s.h.pt......sht.lsphhh................................................................................................................................................................................................	0	79	146	177
+9960	PF10128	OpcA_G6PD_assem		Glucose-6-phosphate dehydrogenase subunit	COGs, Finn RD, Sammut SJ	anon	COGs (COG3429)	Family	Members of this family are found in various prokaryotic OpcA and glucose-6-phosphate dehydrogenase proteins. The exact function of the domain is, as yet, unknown.	21.30	21.30	42.30	41.80	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.75	0.70	-5.49	65	561	2009-01-15 18:05:59	2007-07-31 10:47:06	4	3	535	0	172	439	195	257.90	38	76.06	CHANGED	sssshSpp+PsRlIsl...shssspss......................................L-ApVps........GussusuEhllLRssussh.pcstulVhPLLlPDhPlhlWWsus.sPssshhc.LuphupRhIsDosthss.PhtsLpthtp.....shssussDLsWsRLosWRphLAtshDtPspcs....lsplslsst..ss.....sP.suhLlAuWLAsRLshslppttstt......................................slhulcLtsp.......ssslhLs.stsut.shplptsGtss......pslslscpsspphLAc-Lc..RhssD.lYtpul	..............................hAscAS+cHPsRlIsl......spssscss..........+........................................................LDApl+s............Gu-..uGsuEhlVLRhpGshu..p+ssSVVhPLLLPDsPVVsWWPss.u..P..s..ssu..pD..slGtlApRRIT.Dus.ss...pc..PhpsLtp..h.ts.......sassGDoDLuWsRlTsWRulLAuAlDQsPtp......lpus..pVput.....ss..................sP.sstLLAuWLutRLssPVp+ssstss........................................................ulhslpLsps..........suslhlpR.s.sup...hAslph..sGpss.............phluLs+Rs...st-hLuEELR..RLcPDclYstul..................................................................................	0	53	128	162
+9961	PF10129	OpgC_C		OpgC protein	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4645)	Family	This domain, found in various hypothetical and OpgC prokaryotic proteins. It is likely to act as an acyltransferase enzyme.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.37	0.70	-5.77	62	563	2012-10-02 17:00:17	2007-07-31 10:47:48	4	3	419	0	168	593	70	345.30	29	88.01	CHANGED	RDhR.lDhaRGlALhhIhlsHl.....Psshhp.hlTh+saGFSDAAElFValSGhssuhsY.uphht.....cpGhhsust+lh+RsaplYhAalhlhhhhlshhuhhuhhh...psphlpph.....................slthhhppPht..slhshlhLpapPshhslLPhYlllhhhhPhllhhhhpt.sthslusShsLahsAthht..........hslssaP...sshtWaFNPauWQlLFVhGhhhuhthtpt....thh...hpthlhhlAhuhllhu.hhhthhhhh..h.t.h.......s.hh.thhhs..hsKopLu.hRllHhLALualssphls.tshthhp............t.hhpslhhlGppSL.VFssGshLuhhsphlhtth.ss....shhhp...hll.shsGlulhhulAhhhphh+p	.......................................................................Rphc.lDhaRGLsLlhIhlsHl..........sssl...lp.....hh.....T...h+.....s..a.....Gh.s.....D.......A.....A..EsFVFlSGhssuhsY.uph..hh.....c.t.sh.hsus...t+hh+RuhplYhsalhhhhlhls.hhs.....h.......hsh......h.hh.......ps.hltph.....................sl.sshhppPht......slht.h.l..hLphpPshhsl...LPhYll.....hhlhh.PlhLhlhppp...h...hhLuhS.....sslWhh.uthht....................h..shsshs..ss.hW....a.FNPhuW.Qh....LFshGhhsshtstttt.....hh......hp.....h.lh.hl.usu.hl..l.hs..hhht......hhhhhs.h.................hh...h.hhs....sKspLuhhRll.phlAluaLhsthl.....hh.thhh............shhhcslshlGcpSL.lFshGshluhhs.p.hhhhhs..ss.........shhhshhlshsulshhhhhAhhhph...t...........................................................................................................................................	0	30	79	113
+9962	PF10130	PIN_2		PIN domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG5378)	Domain	Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	21.90	21.90	22.00	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.69	0.71	-4.12	15	82	2012-10-03 20:43:45	2007-07-31 10:51:19	4	1	55	0	44	124	12	122.10	24	90.15	CHANGED	VlDANIlluulLt................................cs+phhlhhsttlchassptshs....Elp+ahstlspppplstpphtshLp....tLhptIpllscslap.phpppAccRhtchDscDaPhlALuLhLsusIWT-D+DFhssGlso.................WTocplphhLs	...................................llDsNllhusllt................................t.hh.hhh...h.....ttphph.hss.phhht....Elccahttl...h....c....t.pp..l..st...cpht....p.hlp....hLhp..h.lplls..pphht..phhppAhphhtp..h..D....c..DhPalALuLtl.....ss...l.W.TtDpch.....................................p.........................	0	15	36	40
+9963	PF10131	PTPS_related		6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG5617)	Family	This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	22.90	22.90	23.10	23.30	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	616	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.99	0.70	-6.37	10	172	2012-10-03 03:08:05	2007-07-31 10:51:56	4	6	156	0	45	127	60	380.40	25	62.59	CHANGED	hRYauPLuYalhAsLphLs.GslhpuatlhlhLshhlGAlu.Whhas++pGp..hluhlsulLalhhPtpl+lhahEGNlPpsss......huLsPhll.lhLahhhc++chRsllshsLhhsllsLoHhMhuAlssluhhlh....lLlhtlh.pp+hlpplhulluhslGls.............huSaWllPhL..+sGlssh-ssusutVhcshohshosuLsPhh......t.uhaYaGlulsllhluGlhhsp+++ssu....................hlssllhllhohsuslsllhpLPlspLlh.hRFsshA..huhllsuhhhhtph+K.........hhslhslhlul...LllDossshphlsassscstpstppl..pptcshscpRlull...DtoshGohsoaal...sshsspsplhGWsaQGusTupsIhhLNpAL-s.......tYatahFDsshphsspolllp+tllocpt..hptlcpss......thsGYphhpcsscthlYp.....ps...sspsatshsphhGlsIG+suh-lsLpasthcsussshl-....Dholp-Lp..+acllYLouhsh+scuphEt.................................................llh+lu+sGs...............pVll-hsch..p..scpstFLG............Vpupshshcs.chpshhasspchsssh.FtpcttpWpsshhsssp..hpshh.lsc+tlthhh+stpss........................plYFlGhNLhaH	.......................................h...sahhhshLhhlh..u....hhu...h...hh.h...hhs.shl.u.sh.....u..hY.....hhu.+h.h....sh.p+ptuhLhulLYhhuhYphps.las.RssluEhlA........huhhPh.lL..h.sh...a.hl.h.p.ct..p...p+.h.hhhLsL..uMohlshu.H....hlohh.hs.s...lhlhla.......llh.h.h........pp......p.....hht..l....h..h..h.h.u...h..shu..ls....................................................hh..aLhPhl............hsss....pp...hp...s.........p..lac.s.h..s....p.sh.s..hh.p..h.......................sh.h.h....l.GLl.lhl..lt..L..hu.hh...hp..t..++.hlh......................lshl.lh.Lh..so.o..h.hPh....h...h....lp.....p..hPhpp..l...Q.F.....P..aRF....lslh.lh..huhh...lu..s....h....t.lh++..................hhhhhllhLsl...........sls.h.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p...pp.thhhhtt...........................................................................................................	0	20	30	36
+9965	PF10133	RNA_bind_2		Predicted RNA-binding protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG1532)	Family	Members of this family of bacterial proteins are thought to have RNA-binding properties, however, their exact function has not, as yet, been defined.	20.60	20.60	22.10	29.20	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.76	0.72	-3.94	20	129	2009-01-15 18:05:59	2007-07-31 10:56:29	4	2	114	0	73	120	3	60.10	34	92.39	CHANGED	MCEuNlYL.hpsspcELlMEsVshlcsps-sl...hLpsIhG-pKhlcu.pIKclsLscH+Illcc	..MCEussYl..hps.spccllMEsVsplpsps.s.p.l...hLpDIhGcpKhlcu.cIcclsLhsH+Illc........	0	32	55	67
+9966	PF10134	RPA		Replication initiator protein A	COGs, Finn RD, Sammut SJ	anon	COGs (COG5534)	Family	Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.42	0.70	-5.08	32	404	2012-10-04 14:01:12	2007-07-31 10:56:48	4	2	282	0	162	499	117	222.40	33	63.88	CHANGED	+DshssM-aPlFSLupp...chp..slpYctss..splpVpsusc..GhATIaDtDILIassSQlhcA.......tstG....cs.o...Rhl+hTsa-lLthssRsTuGcsYpRLctAh-RLpuTsI.....pTslc.sssp..cppcsF.ulIsp.aphl..sc.t..sGRh...hulElpLs-WlYculh...stp.VLTls.-YF.cLppsLERhlYcLA...RKH.sGcQst.WphslppLpcKSGSsush+cFptplRcllpsss...LP-Ypl	............................................................+Dt.shMtaPhFSLuKp....tcht......slcactss..........hplcVp.....us...sch..Gh..ATIa.DtDlL..Ias.sSpls-A..............pstG.....t..u......Rhhpho.s.a-lL.p.hhsR...s.s.uuc.sYpcLcsALcRLpu...Tsl................p.T.sIc....pssp........pc...pcpF..uhIsc..ac.h.........scp.........sG+h........hsl-.lhLs-Whapulh.....psh...VLT..lc...s.Y.F..pL.pts..l-RhLY+ls.....R.KH...sG.c.p...tt.........W..phshppLh..pKoGSh.u....hp...cFth.lRtlhttp.......LPsYt..........................................................................................	0	34	110	139
+9967	PF10135	Rod-binding		Rod binding protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG3951)	Family	Members of this family are involved in the assembly of the prokaryotic flagellar rod.	21.00	21.00	21.10	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.28	0.72	-3.96	174	1787	2009-01-15 18:05:59	2007-07-31 10:57:32	4	5	1578	0	421	1174	304	49.40	36	20.68	CHANGED	KuMRpus........ps....shh.su..s.sschapsMhDpphApphu.pp.s.GlGLA-hlhcQ	..............................KoMRcu.s.....c-....ulF...su.............p.pschapuMhDpQlAp.pho.pt..t..Gl...GLA-hlhcQ............	0	114	241	325
+9968	PF10136	SpecificRecomb		Site-specific recombinase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4389)	Family	Members of this family of bacterial proteins are found in various putative site-specific recombinase transmembrane proteins.	20.40	20.40	20.70	52.80	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	644	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.14	0.70	-6.48	31	317	2009-01-15 18:05:59	2007-07-31 10:57:55	4	2	305	0	84	286	27	626.70	36	93.99	CHANGED	psshsschthLlcLhcWlR...........stt.ssstp...AhtRlphLlcsL-ppPshpsplpshltsllpphchhsLas-sGlhs+sGFhuElscRltt+lLPssP-ps-ls-LhsllFsctpDspWlsulscpthtRLhpLl..............sstscpph....ssphppsllsAlphLusplsuhGlsP-lhpph.sp...........................shcsoPFhsLpc-stshhsthtptppss...........chspLcshL-pCRsslsplap+hcps..GlSVsLsFpLcRl+ppLtRlctLLsllh.......ssstspthscLhspLlpsspc+pSlptLhssssphLAp+lsEpuucTGEHYITcs+pEYhtMh+uAAGGGhlhAhhshlKhhlsuLtLusFhcGlhsulNYuluFlLIahLHaTlATKQPAMTAsAlAuplcss..scsp...slcphV-.lspllRSQsAAlhGNlhlshPsAlhluhhhthhhGpPhloss+ApthLcols.h.usolhaAAhsGVhLFhSuLIAGahDNhhshc+lsptlthp.hLpthLGtptApRlAsahcpNluulsuNlsLGhhLGhsPslushFGLsLDlRHVshSouslGhAhsslGhpshphsthhhAlsGlslhGhlNlsVSFuLAhhlALRuRslphsstpplh+ulhpRlhppPhsFhhP	.........................t...tpt.phLhtLhpaLR..................sst.pt......sttRlchllpsLcpsPphtsphuphlhthlsphchhsLhscsGlhu+puFhsEhspRlhp+hlPsh.-tspLtplFh.hl.F.sp.sDspWlpslspcphhpLhpLl.............stspppppt....ttphpcphLtAlphLohpluupuLpP-lhphh.sch...........................hpt-SPFlsLp+E...hhthhptht.pspts............................-sspLpVhl-QC+s.lsplp++spps..GsSlplsahLcRLcQpltRlchLlslhs....................tstsp.pthhpLhspLlpAstpppSlppLhcsshphLARploEpsucsGEHYIoRs+pEYhpMhtuAAGGGlllAhhshlKhhls.sh.t.lus.hhpulhsuhNYulGFhlIHhLHaTVATKQPAMTAushAppl-ps.......upst.....sh.p.clspLllslhRSQssAlhGNVhluhPlAhhlshuhsthhttsllssppAthpL+Sls.h.usolhaAAIAGVhLFsSGlIAGahDNhssatpltpRLthp.hL+thhu.tttp+hAsah+cNhuulsGNhhFGhhLGhssslGthhGLPLDIRHVsFSSuslGhAhsshsh......shshhhhulhuVhhIGllNlhVSFuLAlhlALRSRsl+hsph+tLhpslhpplhppPhshFhP..........................	0	19	51	70
+9969	PF10137	TIR-like		Predicted nucleotide-binding protein containing TIR-like domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4271)	Family	Members of this family of bacterial nucleotide-binding proteins contain a TIR-like domain. Their exact function has not, as yet, been defined.	24.70	24.70	29.70	28.30	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.48	0.71	-4.50	28	258	2009-09-11 12:22:46	2007-07-31 10:58:20	4	8	238	0	79	235	14	122.30	31	42.51	CHANGED	+VFIVHG.HD-sAKpcVu+Flc.pLGlcsIILHEQs.spGpTIIEKlEphus.VuFAlVLaTP-DlGsttspts........hp.RARQNVVFEhGahIGKLGRs+VssLl.KG.slEhPsDluGVVYsshDs.s.tuW	.............+lFIlHG.+-p.thtp...p.ltphL.c.p.h.sh.cs.l....lhppps.......st...G....p.T...l...l.E...cl.Ep..t..s....sp....ssFAlllhTPDDhuhhpsptt.............................p.pARpN..VlFEhGhhhG+LGRp..+lhhL......h....cs...sl-..hPSDltGlshhphst.....................................	0	26	54	66
+9970	PF10138	vWA-TerF-like	Tellurium_res;	vWA found in TerF C terminus 	Anantharaman V	anon	Anantharaman V	Domain	vWA domain fused to TerD domain typified by the  TerF protein [1]. Some times found as solos. 	43.40	43.40	43.40	43.50	43.30	43.30	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.19	0.71	-4.49	77	225	2012-10-10 16:07:06	2007-07-31 10:58:34	4	3	174	0	64	274	6	199.20	36	54.93	CHANGED	pA+VsLVLDtSGSMpshY+sGsVQclsERlLulAsphDD....D..Gsl-lahFuschpp...hs............slolsshps.al...........................cph.hs..s.h...........tt.hGt..ss.s.shccV.lspat..............s...ss...........................................PshV....................lFhTDGu..sp.cp.pt.hcchlp..cu..uphPlFWQFVGlGcs.p...............................FshLc+LDs...h...tsRhlD.NusF..Fslccls...plsDtcLY-pLL.sEFPsWlp.......tA+ttsll	................................................AtVsLVLDtSGSM..p...s.....Yp...c.G...s.VQ...p...lh-RllsLA...s...p...hD..D....D.G..plcVahFus...chcp..hs..............slTls.s....hp.s.al..........................pph.pss.....h...h...tthGt..ss.s...slMc-llcaat.pt.........s.ss.......h................................P..s..hVlFlTDGG..s..s..cp.pt..lcchlpcu.....uphPlFWpF....VGlGss.s....................ashLccLDs....h......t..s..RhlDNss..F..Fsh-chs.....plsD...pcLY-pLL.pEF..Wlpts+t.tl.h.......................................	0	14	37	55
+9971	PF10139	Virul_Fac		Putative bacterial virulence factor	COGs, Finn RD, Sammut SJ	anon	COGs (COG4458)	Family	Members of this family of prokaryotic proteins include various putative virulence factor effector proteins. Their exact function is, as yet, unknown.	25.00	25.00	29.00	28.00	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	854	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.33	0.70	-13.22	0.70	-6.61	14	467	2009-01-15 18:05:59	2007-07-31 10:59:05	4	3	251	0	78	343	25	401.00	27	97.56	CHANGED	AI-WlsssRppA.RLspEADuLhhcLRRs+Npu+pLucsutpshslGhFG.SQAGKSaLlSsLAusppGcLpsphs..GcplDFlpclNP...u+EuTGLVTRFo.ppssss.........ssuaPlpLpLloEs-lAKIlsNuaFpDhspppst.hplscppIsshlpphpttppstsssGlos--VlsLhDYhppphspt.p..LpstaWspAhpLAPtLslc-RApLFSlLWGchspLTcsYhphApsLppLupApclhAPLusLV....tt.h.tucuIhsVssLttLsssss..ppltV+PhppGphussVolshApLshLssELhhslsp.st.shhEpVDLLDFPGhRsc.ph.t........t.sssspPluphhlRuKlAYLhERYTspQchssLllCssssppp-VsolutsLcpWlcpTQGEostpRupRpPGLlWAlThaDtRlssphsht............h.......................................................................c-uVpRalucPsc.uWsshLsLs-uGhpRlspaLsphsp.-hKhsRlpEQLsclt+cl..hcshhstaapssssschtcKpphuctlh+sLp...spsth.aGELLctLhssp-plR....pLYhp..............t...sttshssstsss.sstsssshDhFu-sssssss.....s..ss...ttsp-ppaApsVhchWlsHLRpLscsssLlphLGlstpslphLlcELlTuupRLcltppLtpsLtspcps.u.pp-phspRQVhpstslluDFluWLGatplstppR...PsSclpcGptlFstssp..ss.....tpLs+LutpPsstsshYlhDWLVuLtphshcNsGauAupEIospppptLusIL	.................h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	21	52
+9972	PF10140	YukC	essB;	WXG100 protein secretion system (Wss), protein YukC	COGs, Finn RD, Sammut SJ, Desvaux M	anon	COGs (COG4499)	Family	Members of this family of proteins include predicted membrane proteins homologous to YukC in B. subtilis. The YukC protein family would participate to the formation of a translocon required for the secretion of WXG100 proteins (Pfam:PF06013) in monoderm bacteria, the WXG100 protein secretion system (Wss). This family includes EssB in Staphylococcus aureus.	25.60	25.60	26.10	26.20	24.70	25.50	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.02	0.70	-5.88	16	402	2009-09-10 16:26:00	2007-07-31 10:59:25	4	1	395	1	25	209	0	352.10	39	84.89	CHANGED	php+ucl+hp-hhEhpllcphsPhFhc.plsts-DplhlshpsssphhsFppl+ppscp..pKl+huhs.Vtslpca.ppRlshllpP-NllFscsLpPthlHhGl+-slPPh-hs-EchLpphKshllslhstcasF--.Yhuhh-sh+hoshtKplhpucol-sLhtll.csa.cEp-ppp+shthVPK++a+l.Kalululhslll.hll.llYhhFhtpPhQ-shlpuspsFLsssYocVIosL-chsscphPpsspYpLAhSYlps-p...Ls-pQ+csI.hNslTLpSDcpYhLYWItlGRGph--AL-lA+pL-DspLIhaALsphh-pl+sDssLSGcERpccLcslps-lccY.h+ct	..........................t.lsKSpl+scchc.h..LL-pcusaFls.s.clsp.hcD...o.apIpYclscptps.F.-s..I..+phs+s..EKLRhLhN.ltsL.c.-h..po.RhTFhLtPDpLaFs+sthPhhtpRGlpsllsPhs.l.oEt-FLppYKALlIshFspK.sF-sLhpGsLElt+t..T..sFEppll-AtTL-.LsshL-EpYpKpcpchp.pNhshVpKhtaplFKalAluhssloVLLlshLua.hhF.hh.apE+l..cu.puFlKs.DYo.pVlssh--l-sccLsppuhY.hAhSYIpspK...Lpc-pK-sl.LNNlT.pSsccYLLYWh.lGpGch--AlsIAphLDDsslhhhALhpplpplKsNscLSs-cRscchKcYpccLp-hh-K.t...................................	0	6	12	19
+9973	PF10141	ssDNA-exonuc_C		Single-strand DNA-specific exonuclease, C terminal domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4199)	Family	Members of this set of prokaryotic domains are found in a set of single-strand DNA-specific exonucleases, including RecJ. Their exact function has not, as yet, been determined.	22.20	22.20	22.50	22.30	21.10	21.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.01	0.71	-4.80	25	1020	2009-01-15 18:05:59	2007-07-31 11:00:12	4	3	1017	0	98	691	27	186.00	30	25.15	CHANGED	QLhDhRoKp......thhtlspshshh.t..tppht...................tpptshpsctlVlhDlPsshspLcplh.p......tpphppIYhhh.pccshYhsGhPoR-pFtphYphlhppscFcl+pchpcLupaLslscchlsFMlpVFhELsF.VoI-sGllslNppspKR-ls-SpsYQp+pcphch-cpLlYuohpElpcWl	........................................................................hs.Rs.p................t..t...hh.................................................t........p.tps....ctl..VlhDlPps.hppLcslh.p......ppphsplYhhh.....phs.....c.....s.hY.l....sGh..soR-pFs+lYKhl...h..p..h...-.h.sl..+p..c..h.ppL..upaLs..lppphLhhMlpVFhELtF..VT..IcD....Gl..lplNp.ps..sKR..sls-SplYQphppplcspchhhhushp-lhsal......................................................	0	23	49	75
+9974	PF10142	PhoPQ_related		PhoPQ-activated pathogenicity-related protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4287)	Family	Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.14	0.70	-5.98	26	293	2012-10-03 11:45:05	2007-07-31 12:39:29	4	11	226	0	99	405	154	341.20	42	71.85	CHANGED	LssYhpp.tspshpapl..ssstphss.schhhhchTSQpWpspp.sp......WpH.lsIhlPps....shsppALLllssGs.................................t.t.sssssptpsphhttlAppopsslsslsslPNQsLtassp....+cEDshlAaoWptahc....pp-tshPLhlPMstuss+AMchspchhtph.....plcpFlVoGuSKRGWToWLouh.sDpRVtAIsPhVlDhLNhpsslp+hhcsYG.sWshultsYhtpGl......schl.sosthspLhplhDPhpYh.....p+L.slPKallsuosD-FFlsDusphYascLsG..pKtLphlPNssHshhs..ppslpolssFhppl.tpspslP...plphplptsp.....t.tlplpsupt.PppVpLWpAsssss..RDFR	......................................................................................................................LssYhpp.pspshpY.s.....l..h.s..oss.l..st..lhhppapLhSQpWps-s.hV......s.ss...........tWpHpVsIalPcs.......sppccALlllssGh.................................ssphs..st..s..s..-.hs....-...s.L.sslAppTpTlVlsloslPNQhLsFps...Dt.......p....s..............hpED.....-.VuhoWshFhct............sppcthhPLpl...PMspAlspAMclspctLsph...................s.......I..ppF.....lloG.hSKRGWTT.WLoAl..sD......scVc.............AIlPh..sID..l.L.s...h....css...L...cHh....Ypo.YG........N...W...P...l...sFhsY.appGI...................scpl.co..P..s..F..spL.hp.Il....DP.Lp.Yh...........................sRL..slPKYIlNASGD-FFlPD...sopaYascLP..G...s.K.tLRhl.P..Nhs.....H....sls..........phs...po.LlsF....l.s+.h...pp..p.p.........sLP...pl.sh..l..ppph.....................lsVhh..S....Et...PspVhhWoAsNPsu....RDFR..............................................................................................................	0	72	83	92
+9975	PF10143	PhosphMutase		2,3-bisphosphoglycerate-independent phosphoglycerate mutase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4255)	Family	Members of this family are found in various bacterial 2,3-bisphosphoglycerate-independent phosphoglycerate mutase enzymes, which catalyse the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate].	20.50	20.50	20.60	22.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.91	0.71	-4.61	92	556	2012-10-03 05:58:16	2007-07-31 12:40:27	4	7	462	6	268	542	95	172.10	32	41.38	CHANGED	AppGhs.GlhcslssGhsPGSDsApLSlhGYD.PtphYsGRGPlEAhuhGlclpss.DlAFRsNhsTl...ccp......................hlhD+pAG+Ips.cEu...ppLhcsLsp..cl...ss..................phpahsusuaRsllVl....+...uss....h...u......spls.sosP..+.hpGp............ltchhPh.....sp.......s...sAcllschhpputclLpsHPlNt	................AppGhsGhhpslssGhsPGSDsApLulhG.YD.Php............hYp.G.RGsLEAhuhGlclpss...Dl.AhRs........NhsTl...cps................................hlhD+pAG.+Iss..EEu...ppLhptLsp....cl....ss.....................sclpF...hsuspaRtllVl.....+.....Gss...................s.......sp..ls..sosP..+..hssp.....................ltphhPh.....st................tut.oAcllschhpcutc.lLp.sHPlN.....................................................................................	1	107	199	243
+9976	PF10144	SMP_2		Bacterial virulence factor haemolysin	COGs, Finn RD, Sammut SJ	anon	COGs (COG3726)	Family	Members of this family of bacterial proteins are membrane proteins that effect the expression of haemolysin under anaerobic conditions [1].	25.50	25.50	25.50	25.80	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.27	0.70	-5.22	5	788	2009-09-14 08:20:40	2007-07-31 12:46:41	4	3	783	0	95	345	12	204.10	52	86.28	CHANGED	MlRAKLKFRLHRTAIlLICLALLVlLMQGASYFSpSHQhARs-QVEELA+TLARQVAaSLSPLM..GscssNup+IsAILcQLTssSRILDASVYppsGoLVA+SGEsVpVRDRLALDGK+uGSYFNaQIVEPIsGKsGPlGFLRlTLDTHsLATEu+QVDNTTNlLRLMILLuLAIGlILARTL....LQsRRoRWQQSPYLLTAspPVKEE-ES	..................Ms+sKLKFRLHRsVI..VLhC.LA.LL.VsL.M.Q.G.AS.a.F.Sp..s...HQ+tR....ssQL.E..E..LARTLA...........RQVsLslAPLM....p..s-o...sD.ccRIpAlLcQLTcESRILDAuVYDcQGcLlA+SGE...o.VpVRDRLA.L...DG.K.+..A....G.u.YFN..Q..Q..IVEP.I....tG..K.N.G.P.LGYLRlTL.D.T.H.s.L.AT.E.u.p.Q.V.DN.T.T.N.IL.....RLML.L.LSLA.I......GVlLTRTL..........LQG+RT...R..W..QQSPaLLTAspPV.EE--.................................	0	5	24	62
+9977	PF10145	PhageMin_Tail		Phage-related minor tail protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG5280)	Family	Members of this family are found in putative phage tail tape measure proteins. 	30.00	30.00	30.00	30.00	29.80	29.40	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.33	0.71	-4.67	185	2672	2009-01-15 18:05:59	2007-07-31 12:56:46	4	25	1759	0	359	2411	301	209.40	19	20.43	CHANGED	lpptshc..hus...p...............h.sh......oss..-hupuhttls..psG....hs.........spphh.shhtsshph.AsAsst..-hspsushhsshhssath.ss.......pp...ssphs.......Dhlstsupp.u.ssshpchupshp.thussupshGhsh.....pphsuhluhhspsGh.puspAGoul+shhtpl.........t..sppstpshpp..........l..G..l................................................................shtc.........upuphpsh.phltplppth.......tt..hsptpp..tshlp..........plF.........................G	..............................................................................................................................................hppthhp..hut..p........h...sh.....oss..-hupuhtths....ptG.......hs..............spphh.....shhtss.hph.....A..t..Assh.......s..h...s.p.s.uph.h....sphhssasl..ss..................cp.......hpplu.....................Dhlstss..sp.s.ss.sh...p...slucshp...thu.......ss.up.sh..Ghsh.......ccsuA.hhuhhtssGh..pustAuo..uh+s.hhtpl.................sts..sc..pstcshp.p..................L....G....l.........................................................................................................................shtc...........spsph...p.s.h.....phltpl....pth.......tt.....hsptpp.....thht.thhG..................................................................................................................................................................................................................................................................................................	0	106	225	302
+9978	PF10146	zf-C4H2		Zinc finger-containing protein 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4451)	Family	This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.	27.20	27.20	27.70	28.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.83	0.70	-4.33	7	142	2009-01-15 18:05:59	2007-07-31 13:15:50	4	3	99	0	93	126	0	206.40	47	91.22	CHANGED	psItclRsKs.phcKl+sclhcEh-ss-spE+plp-hptph-tL.pEKhuHsEELR.IptDINshEshIKpocs-hp+phphhp+ha-Ehh.l+ttlschhcsh.....LulccL.phcEEE..hlo......................................pA+pshpPp.....hPss..........................PssP...sshhtuhhsstthp.sc...........................tsphc...sh..RpQsPP.......MKsC.SCaQQIHRNAPICPlCKuKSRS+NPKKsKRKp	....................................................................................................tltclRsKTlphEKlKsRlhtEh-shEsEE.+pLcEY+pEM-hLLQEKMuHVEELR.IHADINs......MEssIKQoEs-hs+.hh-ss.pRla.-.EYpPLKcclDth.Rhs......LGLpc..LPsLp...EEE..pp.lo.....-.hap...........................................................pt+t....hps.p................P.................................................................Ps..P......pshtAutssstphpssp.................................................................................p.p.sp..s...sshRQQPPP.........MKuCLSCHQQIHRNAPICPLCKAKSRSRNPKKPK+K...............................................................................................................................	0	35	43	73
+9979	PF10147	CR6_interact		Growth arrest and DNA-damage-inducible proteins-interacting protein 1	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4848)	Family	Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity [1].	21.80	21.80	21.90	22.60	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.55	0.70	-5.02	9	102	2009-01-15 18:05:59	2007-07-31 13:21:45	4	4	86	0	67	101	0	192.60	32	86.81	CHANGED	Mttshhp...pcshh...pLshThs............th..tssp.phhPp+RphhtshhPs.psp...pW.ccs.+YpRchFGRYGht.SGVsPctLaPot.EclcEh.tEchtah.oLppMhcphctpppcccp+tpAREpclAcshtKhPphlAcactphtcpcpctpscKpR+-RLlt-sp-+FGapVDPRssRFpEMLpphEKE-+K+hKttKR+cKcEchhAthsttsup	.............................................................................................t.tt.ph.P..hph.tshhP...ps.....pW.phs.+Ytt+.aGRYGtt.SGVsP.t..h..WPo..Eplc.ch..tE..chtah...oLtpM.cplctppttccp+pptR............EppIAcpMsKMPphltca+pphpc+.............cpctpscKpR+tRLh.tEsp-+hGaplDPRss+FpEhLp..chEKc-+....K+hKttK++tKp.Ethhut.......................	0	22	27	50
+9980	PF10148	SCHIP-1		Schwannomin-interacting protein 1	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4847)	Family	Members of this family are coiled coil protein involved in linking membrane proteins to the cytoskeleton.	21.70	21.70	21.80	23.70	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.54	0.70	-4.97	2	132	2009-01-15 18:05:59	2007-07-31 13:44:20	4	8	75	0	80	130	0	206.90	59	57.02	CHANGED	shpAQ+NERESIRQKLALGSFaDDG.hhaTuCSKSGKssLSSRLQsGhNLQhCFVNDSuSD+DSDA-DS+TETSLDTPLSPMSKQSSShSDRDTsEE-.-S.-D.-FhphQ++LQtEA+hALAhA+PMA+MQVEVE+Q.p..++SPVADLLPHhPHISECLMKRsL+PsDhRDMolGQLQVIsNDLHSQIpuLNEELVQLLLhRDELHhEQDAMLVDlEDLTRHAcSQQ+HMhEK..uK	....................................................................................................AQ+NERESIRQKLALGS......F.a.....D....DsPslYTosS.+uGKPS..LSS.RLQSGMNLQICFVND.S.uS...D.....KD.S.....DADD.....S.....+..T............ETS.L..D..T..P...L......SP.......MSKQSS..Sh...S..D.R.DToE--.S.....ES..L-Dh.D...F.loRQ....+KL.Qu...EA+hALAhAKP.MAKMQVEVEKQNR......K.KSPVADL...L...P.H...M...PH..I.S..ECL..M..KRsL.+...ssD...LRDMTlGQLQVIVNDLHSQIESLNEELVQLLLhRDELHhEQDAMLVDIEDLTRHs..pupQ++.t-+...................	0	21	28	62
+9981	PF10149	TM231	NAcGluc_Transf;	Transmembrane protein 231	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4838)	Family	This is a family of transmembrane proteins, given the number 231, of unknown function. It is conserved in eukaryotes.	20.50	20.50	22.90	21.10	18.10	20.30	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.89	0.70	-5.44	7	132	2009-01-15 18:05:59	2007-07-31 14:10:04	4	6	95	0	88	132	1	236.80	31	81.00	CHANGED	Mthaslas+sshlhY+spLCShAoLhlhhhlhLohh.P..LlshhpshuhW.cppshhEQPsVpFpYphlhluph-s.......stuhlAhSoFssFN.pLpsps.psstlpshpEDsNhDGppDtLphpl..pLP.pso.plhthpLllhF-hpLpphsshsh.ohhslphp.P.....hhuupl.hpG-LpLpQ....psPhshRslcopas.Vpl.hNuoss.hspaphcsIhtph.ctNsuha.hsspph.Wphspuuts..h.lchtl...ch.p.slhY+suhWpplt.hWlpYhSlLhI.Lalhp+lKpFlFpppllpohpl.lPaKc	.....................................................h.hatpsh...h.Y.st.hohuslhhhhhhhhthh.P..llhhhpstGhWh+pssa.EQPsVpFpaphlhls.hs.........tthlshSo.a.sth..N.phtss.p...h.......ph.s.......hl...phh.........p......pDh.NtDG....ph..Dhlphpl..pl.shpst..plhthpll..hhFphpLpphsph.hpohhhhp...t.s......h.supl.h.G-LpLpQ....pts.h..ts....h.....p...a..........p.hpl.hstst...h.p.......aph...pplhtth.ptN.shh..t....h...ah.s....s.t.ts...h.lph.l..........ph..........h.............Y.....suhWEhlK.hWlQYhuhhhlhhalhpclp.alFppplltoh.........................................	0	31	40	66
+9982	PF10150	RNase_E_G		Ribonuclease E/G family	Bateman A	anon	Pfam-B_234 (Release 21.0)	Family	Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs [1].	22.70	22.70	22.70	23.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.64	0.70	-5.17	173	4570	2009-01-15 18:05:59	2007-07-31 16:14:19	4	14	3079	16	1101	3529	3482	263.90	41	37.13	CHANGED	olsGRYlVlhP.......pssp..lGlS++Icsc..p-Rc+L+....plh.........................ppl...hsps.......hGlIlRTuupssspcclppDlphLhchWppIpcc.tpptt...........PsLlac-.slhh+slRDhhssclpclllDs....ppsapphppa.h..pphhPph.hp..pl..phap....sp.tslFctaslEppIpcsh.p++V.Lt...SGGallI-pTEALssIDVNoGph.sspps..h--Tsh+TNlEAAcEIARQLRLRslGGlIlIDFIDMpspccccpVhctLccslcpD+s+splssho.pLGLlEhTRKRhR	.............................................................................SLsGRYLVhMP.......sss+..sGlS++I...-s-.ERpcLKchl...............................tpl.....hs.cs.................hGlIlRTAu....t.Gtst.--LptDlsaLh+hW.ppIpcp....tp..p...tt...s..............................PhLlapEss.lhh.RslR...Dh.h.s.p.-...lscIllDs...................ppsa.cphp.pa.h...p.h...hPch...ss.................+l...chY.p..............sc...hPlFstaplEspIpp..Ah..pRcVpL.....SGGhllIDpTEAhTsIDlNoGph...st.t..............t..s.............lE..-Tsh.pTNLEAAcEIARQLRLRsLGGlI.lIDFIDMs.stccp+tV.pp....Lc....cALpp.D.Rs+h.plstlS.phGLlEMoRpRh.......................................................................	0	343	700	917
+9983	PF10151	DUF2359		Uncharacterised conserved protein (DUF2359)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4467)	Family	This is a 450 amino acid region of a family of proteins conserved from insects to humans. The mouse protein, Q8BM55, is annotated as being a putative Vitamin K-dependent carboxylation gamma-carboxyglutamic (GLA) domain containing protein, but this could not be confirmed. The function is not known.	19.80	19.80	20.00	20.90	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.50	0.70	-5.97	6	158	2009-01-15 18:05:59	2007-08-01 11:58:53	4	5	88	0	99	172	0	346.60	30	64.08	CHANGED	HGYRlCIQAlLQDKPKIsTsNLscaLELLRS+QsRPhKCLTIMWALGQAGFssLopGL+VWLGIMLPVLGlKuLSsYAIAYL-RLLLhHsNLTKGF.GhlGPKDFFPLLDFAaMPNNuL.................................SsSLQEQLppLYPRLKVLAFGAKPESTLHTYFPSFLSRA.TPuCPs-MKKELLsSLT-CLsVDshShSVWRQLYsKHLuQSSLLLpHLL+oWcplPpKhpK.SLp-TlQSF+VTNpEh.tKGuuusp-lpsCsoACpuL.pKh+GsuhPWsRLLL.lLLVFslGFlsHDlRoHuSFQuSpTuphLppSGlhssuQQAhu+lpsYShQG.SWLpcshPtahSchlpVltPshp.uhs+hptsssFlst+stshlsahp-plsphhphl.tphP-sl.QhhthL+ELLLhhh+shlLPshthLhtsltth.pph.tuCpGcVohsClpspl.phup.oWhhLQcsTsshhs.tluh	.............................................................hlh...Pphh...h...h.....psh..pp....hhl.slhWsluQAuhssLs.GLplWhtlhLPlL............s.....hK.....s.....h..u.....s.....hs....l....t.hl.-........Rl........L.....................hps........s........l.....p........c.u...........t....hlsPppFhsl...hc.hsa....s..p..ssh.................................s..shp-phptlYPpLK...luhu.u.ps..to......p....h.....pp...h..h.p....h..h...s...cu...ssps....s....s...p..h.....pcEh.h.s.shh..CLs...s..s..shphWcp.LY.cpLptS.....shLLp+LhpsWcphs.tKh.....p..p......s......L.pcTlpSh+hpNpch..hp..cu..p..s...ppp....sl....hs....s.......cthCc.....slhtp.............h.......p...u........t...........h..hsp.........h..hl...hllhhhs..G.hlhaD..h..t.t..s...httS.st.hLppsG.....hh.h.ppsh.hh..h..tu.phht...s.h............t.............ht........................h.....................................................................................................................................................................................................................	0	23	39	65
+9984	PF10152	DUF2360		Predicted coiled-coil domain-containing protein (DUF2360)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4496)	Family	This is the conserved 140 amino acid region of a family of proteins conserved from nematodes to humans. One C. elegans member is annotated as a Daf-16-dependent longevity protein 1 but this could not be confirmed. The function is unknown.	24.30	24.30	24.60	24.30	24.00	24.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.79	0.71	-3.92	22	332	2009-09-14 15:15:59	2007-08-01 13:41:33	4	33	124	0	252	294	3	108.90	26	34.36	CHANGED	lNpFllpTlpFLNRFushCEsKLsphppplQplEtphtlLEsKL...uSIs...................Ghppl.............................................sssssssssppsss.sssss................t.stssusssptsshtsss..t.................P.h...shhphp..pDPRYttYaKMLplsVPstAl+sKMpt-Gl-PshLDs	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s......t......s.hhthp....c-PcY.sKYFKMl.ph.GlPhtul+tKMht-..G..lDsslL-.............................................................................................................................................	0	124	163	225
+9985	PF10153	DUF2361		Uncharacterised conserved protein (DUF2361)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4484)	Family	This is a region of 120 amino acids that is conserved in a family of proteins found from plants to fungi. The function is not known.	25.00	25.00	28.70	25.50	19.50	21.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.46	0.71	-3.89	28	193	2009-09-10 22:45:35	2007-08-01 13:50:37	4	4	165	0	142	189	2	111.10	35	37.80	CHANGED	clK++IRDlERLLp+c...sLPsclRl-pERsLpuL+hcLps..pptcppp+Kh...hcKYHhVRFFERKKApRclKpLcKphcps.s...........tttchcphpcpLcpsclDLsYVlhFP+sEKYISLY	........................lKp+IR..slcRLLp+p......sLPsslRlppERpLpuLcpplpp....pptppt....cpph.......hpK....YHhV......RFF...........ER+KspRpl+pLp+phcpsp...............................tttph.pplppplpttclDLsYsh..........aaPpsEKYlSLa.........................................	0	44	84	122
+9986	PF10154	DUF2362		Uncharacterized conserved protein (DUF2362)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4506)	Family	This is a family of proteins conserved from nematodes to humans. The function is not known.	25.00	25.00	27.60	27.60	22.80	22.30	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.65	0.70	-5.83	7	140	2009-01-15 18:05:59	2007-08-01 14:11:51	4	4	99	0	101	136	2	381.70	37	82.64	CHANGED	ppshscLptplhhl+t...Pph....h-psLcpsLppFl-p..EslschDccAEthlpthtptcs-hptlspsht+hYs-phLEaAc..tss.-EpFApsaHpLlHSss.pplLshE+sYhhslophhpcpD.Elcphpphpt.EhsK.hppLstolsspDlN.shhAppapsQp.lcp+auoELpphpshQKpEYpcWV...........sSpls-phpsQstp.ptsustsshh.ppppphEESFTIHLGuQLKpMHNlRLlpsc.hhDhCp....hcscto..phpRLphAhuLYSoSLCGlVLLlssp...hss.c+-FhpssppsT-FHFspl-cQLEhlppsl..L.sptp+sphpctp.spsspstusts+sc..........+p.sslhsG-FaITRHSNLScsHVlFHLslD-slpS.....upIsuRcPsIhGLRNILKssspHDITTIoIPlLLhH.-MSE-MTlsWCl+RAELVFKCsKGFMhEhsSWsGu.....pTVQFLlPpsISEphFhpLusMlPplF+VusshhL	.....................................................................pl..ptLppFlpp..pp.p..scpsp..lpth.t..ptp.sl.pthhptht+.atpp........hlpasc....ts.....s...............--....FutsaHpLlHS..s...s.cslLphEptahhsls-hhtttc.plpphp.pp..............p..........t.EhpphhppL.......shshosp-lN.slhupp..hpppp...............l..cppapsclct.pthQ+pEYppWl.th.t..............ss...th.......sp........h.....h.p..s.....................p......s....pt......t....pp....t...........h-ESFTIa...L..G.uQLKpMHNlRllpss..hh-hCp.................hpspts...........pRLphAhuLYSssLsGlVLLs.......s.......s.p.......hsshpc...........phhphsppsT-FHFspl-pQL.chlpp.h......h...t.p......pth.ppt........p.ttttt.................................................pp..pl.....s.G-haIT+HSNLu...........p.....h.HVhFHLssD-.s.lpS.....spIsuRcPslhGLRNIL+ss.spaDloTloIPlLLhc..-...hsE.....cMTl...s....W........Cl+RAELVF..............KClKGFhhE..soh....sus...........polQhllPpslo..cphFhplsshlPplF+lsssh.............................	0	46	53	81
+9987	PF10155	DUF2363		Uncharacterized conserved protein (DUF2363)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4508)	Family	This is a region of 120 amino acids of a family of proteins conserved from plants to humans.  The function is not known.	25.00	25.00	26.80	26.90	21.90	19.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.55	0.71	-4.20	16	204	2009-01-15 18:05:59	2007-08-01 14:17:11	4	3	134	0	149	197	3	120.10	58	30.15	CHANGED	lEpNPplAh-lLh+lhpos.p........hp-YhcsLlsh-lolpShElVN+Loppl.......pLPp-FlphYIspCIpsCpslK..-+.hQsRhVRLVsVFlpoLI+sKllss..+-LhsElpuFClEFS+lpEAssLF+hlKs	............VEsNPllAlEhLlKLhpSs..p........................Is-YFslLVs..M-MSLHSMEVVN..RLTTuV..............-LPsEFlHhYISNCIuoCEp.lK.........DKYMQNRLVRLVCVFLQSLIRN.KIINV....pD...LFIEV........Q.......AFC..lEFS..R..IREAAuLFRLLK..........................	0	71	93	123
+9988	PF10156	Med17	DUF2364; 	Subunit 17 of Mediator complex	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4512)	Family	This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.42	0.70	-6.22	28	294	2009-01-15 18:05:59	2007-08-01 16:06:26	4	5	238	3	216	270	0	390.00	21	67.52	CHANGED	Ms...............psh.lsLcP.....................tt..pp...........s..................................lslcphIspIhtEhG...sFtslsEcoLpccIppppsptptsptspp...........ppccspssp................................................................ppsph-ph.pt..+p-lhpplppAhsEssluLDFlSLLlSphpsp......................uhsohS.....PhLcphsPsuSLs...u-hlt.s..ttpttht...............ptlspGWKhcuLspAsshLhpuup+Lppplpp...........Epc.................................................................YWpcllplppps.....Wtlh......+h...tpspp.lGlcYGat-uGspF.+ccGlAsLRpssc.uslpl................s..........shthpts+hlRV+Ih......csthlsGp.Sphs........p.tssssslpspIppA+pslFEcELFapLpREAppLhshslplps..Nplhhpls.......sppltI-L..........lsh-cps.tstpt........sp.psthApslhtsL+lLLsthH+psLpp+tpsssshs.h.....................p.p.sss.hlLRPlluhh+Hpphhphhpphlsslspslpsss	............................................................................................................................t...................................................................................................................................hslpt.htp..tphu...t.h.lt..shpppltp.ttp..s...tptttp............pppptttt......................................................................................tpptt.c....ph......hp..plh...pplp.......pAhsEhslhhDhl.Sllhsp..................................................................................................thhshs..............Ph.pp.....hs....tphs..................................................................thlphhhKhcuLst..uuphLhpuAp.cLpppltp....................ppc.................................................................aapcllplppp......Wplp............................phts.lh.sc..h...u...a...tpu..u.sha.pptshtsh+psp......tshth..........................................................................s...hpt..thlp...Vpl.........tsh.hss...pt.............................p.t.ts...p.hppp....lptA.......p.......pslhpcElFtpLsREAhplh.s.....h...sph...h....stlhhph..........s...pl.lpL............................h...sptt.tt.t.................................pths.hl.h.L+.L.lt.hactp.pph...s.ss.s.h....................................p.p.p.....lLc.llt.hpH..hhp...htthlpphst.l.........................................................................................................................................................................................................................................................................................	0	70	116	175
+9989	PF10157	DUF2365		Uncharacterized conserved protein (DUF2365)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4514)	Family	This is a family of conserved proteins found from nematodes to humans. The function is unknown.	26.20	26.20	26.30	27.30	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.77	0.71	-4.32	6	109	2009-01-15 18:05:59	2007-08-01 16:13:18	4	5	96	0	81	116	0	135.70	33	51.13	CHANGED	csGchTHFVAcNLEtKIR...............pSucpo.TPssusGPh........hsht.h.p...IP.....lDPsVLsDlEpcuQtLAsSVDsLLcsLsusLHulSulTs-slpsY+sAVsKLsDslDuNIKshYsLLAKsEEls+SMpPscpLAppIR-IKRLVDhLEolh	.................................................t..st.h.FlspsLp.+l+...........................s.........s.......ts.tsh.......................t.h..p.t.lP.....lDss.lLp-LEpcupplussVDpLhcsLsuslpp.houlolsslpsa+cuVspls-.u.l.DtsIKu......hYpLlA+sEELs+uMpslptLAppl+cI++hl-hh-sh..............	0	32	41	65
+9990	PF10158	LOH1CR12		Tumour suppressor protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4515)	Family	This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression [1]. The exact function is not known.	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.62	0.71	-4.36	5	152	2009-01-15 18:05:59	2007-08-01 17:47:16	4	5	94	0	69	138	0	104.40	47	44.96	CHANGED	pFLPVL+GlLSupTs.pTNp....pLERLcSppllpLCoRhQ-HLspCAcAVAuDQNpLVcRIKEVDsSlsoLauthp-+QKpYAuYAEQluKVNplSspLsRIQhlL-QsVPhMEpLNshLs--ERLEPFsh..................+P-	..............................pF.PlL+tslout...Ts....s.sp.....hLE+....LsSppllplChRhQs....HLp.CAphVA....-QstLstphKph-.thtpl.....ht.h.ptpcpaspasp.pht+...lpphpt.lpchp................hlpp.l..h-tlNphLs.tcpL..hsh........................	0	22	27	50
+9991	PF10159	MMtag		Kinase phosphorylation protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4520)	Domain	This is a glycine-rich domain that is the most highly conserved region of a family of proteins that in vertebrates are associated with tumours in multiple myelomas. The region may contain phosphorylation sites for several protein kinases, as well as N-myristoylation sites and nuclear localisation signals, so it might act as a signal molecule in the nucleus [1].	25.00	25.00	26.40	25.10	24.60	21.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.83	0.72	-3.94	16	182	2009-01-15 18:05:59	2007-08-01 18:10:29	4	5	163	0	133	175	1	77.70	55	27.33	CHANGED	GsRGGpspFpW-DV+ssp..cR................ENYLGHSlh.APVGRWpKG+DLpWYsK..scsssuptst........ph+EElp+lKptEpcAhttALG	.........GsRGGpspFpW-DVKs..sp..cR................ENYLGHSLh.APVGR.WQKG+DLsWYAK.........scss....s.s..s..t....................pccEElpclKcAEc-AhttALG.............................................	0	46	76	103
+9992	PF10160	Tmemb_40	Tmem40; 	Predicted membrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4536)	Family	This is a region of 280 amino acids from a group of proteins conserved from plants to humans. It is predicted to be a membrane protein but its function is otherwise unknown.	25.00	25.00	25.10	36.70	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.87	0.70	-5.16	7	145	2009-01-15 18:05:59	2007-08-02 10:45:22	4	3	83	0	90	124	1	232.70	37	73.71	CHANGED	hc.luss+sphashlLllPslhFhhFLhachspuhsKLphspS..IhluaYhLlalVullslhhshlphh.shsst......pshWpllphF....hLhlElSllhFhLthsahsutpSlpRshllouhlshh.slsQshhphths..hsLhhs..s..pcGththWlhpphlhhhVYhhlhhh..hp.phR.+LPu+suFY.YhhhhhhLNhlphhusuLhsspst.GhhhhsloshhYaulahPLlYlTFLtcFhpp.....................D..L.ssahu	.........................lsps+shhaslhLllPslLFhlFLhh+h.puhtKlp....hspS..IhloaYhLlalVullslshshlph.h..sssst......cllWplhphF....hLslElSllhhh.Lthu..al.p...utpSlpRsLhlosl.....luhs.olhpuhh.hhas.....s.L.h..c.....s...h....s.hh.sc....GthtaWlhpphhhhhVYshlhhh...h..+.R..p..LP...............u+.uFYhYsshhhhLNhlphhGssLls.h.s.hh...Ghh.hhshTshhYauhahPLl.YhsFLtsFFtpp....................c..L..............................................	0	22	42	68
+9993	PF10161	DDDD		Putative mitochondrial precursor protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4542)	Family	This is a family of small conserved proteins found from nematodes to humans. The C-terminal region is rich in asparagine. Members are putatively assigned to be mitochondrial precursor proteins but this could not be confirmed.	21.00	21.00	23.40	22.30	20.90	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.53	0.72	-4.35	9	96	2009-01-15 18:05:59	2007-08-02 11:08:41	4	4	78	0	69	85	0	76.30	44	71.82	CHANGED	ssphustssshulh.h.hposhshpSGAltP+PpphsFGLLtlhhsVIPuLaIGuhISKNhAsaLEENDlFVPsDDDDDD	.............................ts..............h..RoshsspSGA..lhP+P..chsFGLL+l...........hslVI...Ph..LalGshISKNhAshLEEpDIFVP-DDDDDD.............	0	19	23	47
+9994	PF10162	G8		G8 domain	He Q, Liu X, Bateman A	anon	He Q, Liu X	Domain	This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.	21.00	21.00	21.10	22.90	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.55	0.71	-4.33	34	504	2009-01-15 18:05:59	2007-08-02 11:58:43	4	98	97	0	317	448	35	124.80	30	7.75	CHANGED	soWtst.....pl.........Pps..ucsVhIssGpplllDss....ss.hpplhl........pGpLlFss.....pshsLpspsIhlpsG..plphGoppsPa.....psphsIsLpG.........................spsssph.......shGsKsIulhtsGsl-lHG...............csoWTcLss	...................................................Wt.st.................Pp..s..uspVhI..pGphlllDss.....sshhphlhl......sG...pLlFs-................pslpLps.c.hIllpsG................u.pLplG.o...cpsPa.....................ps..chpIsLhG...................................................................pts.ssph.................sshGsK..s.lu..........Vht.GsL-LHG...............hphs.WTpLs.t....................................................................................	0	146	187	233
+9995	PF10163	EnY2		Transcription factor e(y)2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4479)	Family	EnY2 is a small transcription factor which is combined in a complex with the TAFII40 protein [1]. The protein is conserved from paramecium to humans.	20.50	20.50	20.80	20.70	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.71	0.72	-4.05	24	256	2009-01-15 18:05:59	2007-08-02 12:50:33	4	9	183	24	181	241	1	83.10	35	66.19	CHANGED	plcstlppp...LlpS..G-pc+lpchL+t+LhEsGWpDcl+phs+chlpp...............tt.sslsh-cLhshlsP+AcshVP-pVKp-lLp+I+saLs	...................hpstlppc...Llco..G-p-+Lc-LL.+p+L..h....EC.GW+Dpl+ths+.chlcc...................puhp..sloh--LlsplsP+uRs.hVP-sVKpE.LLp+I+saL.h............................................................	0	67	94	144
+9996	PF10164	DUF2367		Uncharacterized conserved protein (DUF2367)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4517)	Family	This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. The function is unknown. Several members are putatively assigned as brain protein i3 but this was not validated.	22.00	22.00	24.00	23.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.38	0.72	-4.15	4	109	2009-09-11 06:36:34	2007-08-02 13:25:12	4	1	77	0	78	100	0	88.90	38	74.20	CHANGED	hPsYGAh-ous.tsPlPlV....lpssPsutPph............hsp.IIVVGGCPsCRIGhLEDsaoChGIhCAIFFFPlGILCCLAh+pRRCoNCGs.F	.........................................................................................................s..............s.......t..........................sp..llVl..G......G.CPsCRlGsL.E..Ds.F.TsLGIhh...AIhhFPlGll.....CChuh...Rp+RCsNCGAhF.............	0	35	40	62
+9997	PF10165	Ric8		Guanine nucleotide exchange factor synembryn	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4464)	Family	Ric8 is involved in the EGL-30 neurotransmitter signalling pathway [1]. It is a guanine nucleotide exchange factor [2] that regulates neurotransmitter secretion.	25.30	25.30	28.10	26.00	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.60	0.70	-5.66	23	341	2009-01-15 18:05:59	2007-08-02 14:02:37	4	3	198	0	221	310	0	380.40	31	83.45	CHANGED	sLpsl+lluR-hpshsPhhocculph.LhpaAth...................................................................................................................psss.csthEALKCLsNhlh.sspsp..phhschthsstlscpLpps.t..................sp-scahthRLlFLhTu.sststppLhpchpslshlsttLppphpptspstpt....................-t.tlsEsLKllFNlThhhscpts.............p.uspht+lsslLpcl..................shsps.h-shhuphlNhLssL.sLpshcs.....hppssl................................tssshsslctLlphL-pplpph................pshc...............-plsPlLslLschschs...............................ctsR+al+ttlLPs...cDhcp...t.-pusoLpu+LlRLhTps..sslKcsuuEhLFVLCpcsss+hlKhsGYG.AAGlLAsRGl..sh......tp..t...............tauss.pcu-T--.............hpphp.sINPlTGph.s.-p....ssh-s...MT-EpKEtEA.+LhsLF-....+hpcpGllps.............tthhp-G+	..........................................................................hLptl+lhuR-.p.shsshhscps........hph.Lhphu.................................................................................................................................p......p...shhEuL+CLsNhlh.s..sp.........phhh..-h.t.hs....t.l..sphlpt.........................................sp-.p..hh.shRlLFLho..hhpst.h.hppLhpch..phhph..lsphl..pttht.....hh.ttt.t.....................................pp.thhEhLKhlFNlTh...c.t..............................p.stth.hlhslLpch..................s.stp.hpth.hsphlNhLssl.slp.shc..s................ptt.s.h.........................................................................................................................s.shpslphLlphh-pplpph......................................pt.c.......................ptlsPlLslLpchscht...............................cthR+al+......t........p........lLPs...cDh..pp.......................h.p..h..us..s..lps+LlRLhTpss..sl+phsuEhLFl..L...C.......pcs........s...sphlKhsGYGsAAGhLss+Gl.....sh.......tp.....t............................aSp...p.psoco--..............htphp...tlNPl.TGph.p...........ssh.t....MT-EpKEhEA.+Lhshh-....+Lppptll.p.s..................................................................	0	72	106	168
+9998	PF10166	DUF2368		Uncharacterised conserved protein (DUF2368)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4544)	Family	This family is conserved from nematodes to humans. The function is not known.	25.00	25.00	34.70	34.50	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.77	0.71	-4.54	13	98	2009-01-15 18:05:59	2007-08-02 14:20:32	4	2	76	0	72	84	0	127.10	39	88.52	CHANGED	MGt..shu+u.p.pNh+cpQEa.....chQhERQLtMppph+pRQhAhplApuREhhpW..huuFaslssluhssuhhK+K.......+PshlsPllPLuFlluYQhDhuYGsplpRl+uEAEpIl-pEpp.LLphPtGh.TlcsI-c	...................G...hhscs.s...tsh+p.pQ...Eh..........chQhERQlhMQspMRERphAhp..IAhuREhhpa..husFaulAsluhsuuuh+.pK.......+s.shlhPllPLoFllsY...QhDhuYGohlpRh+uEAEpIhcpEpp..hLphPtGh.Thpsl-p......................	0	28	32	53
+9999	PF10167	NEP		Uncharacterised conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4523)	Family	This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteristic NEP sequence motif. The function is not known.	25.00	25.00	27.60	26.20	23.40	24.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.41	0.71	-4.40	7	127	2009-01-15 18:05:59	2007-08-02 14:45:11	4	2	98	0	89	113	0	107.90	33	64.56	CHANGED	hp-sEhth+h++so-KhoEslahlANEPSluLYRlQEHVR+slPpllp++s-lhphppphpGtsYDlEYuhpsVKohpc.....us.hFpsIpphL+puIthKpplpss..pu+p..cpptsssSs	..........................ph..thtc...so-+hoEslhllANEPSlALYRlQEHlR+ulPtlspc+schtphppp.pGthaslEYuhsAV+shtc.....us.hFcslpphL+puIth+pphpht...ps..............s..................................	0	30	46	69
+10000	PF10168	Nup88		Nuclear pore component	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4460)	Family	Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain [1]. Nup88 is overexpressed in tumour cells [2].	20.00	20.00	20.00	20.00	19.60	19.90	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.25	0.70	-6.69	5	211	2009-01-15 18:05:59	2007-08-02 14:58:37	4	6	126	0	142	223	0	392.10	22	73.25	CHANGED	G-pWpppLscHcLFs+L+EGL+lppcTppct.t................+NLLsCLDG-LFlWDucESsFLVsNLRSssusuppsshSpYQTLLCoNPPLFEVscVLlSPoQaHVALlGsRGVsILELP+RWGKcSEFEGGKpsINCRThPlAERlFTSSsSLsLRQAtWYPSEspEPHLlLLTSDNTIRlYNLp-PpoPs+VssLSph.c-osl+ssupoatASLGETAVAFDFGP..............................LussPKsLsGp+..uKpEhlsYPLYILYENGETYLlYISL.+psuslGKLhGPLsMaPuAEDNYGYDACAVLCLPCVPNIIVIATESGhLYHCVVLEAEE-E-touNEsWDuss-psPSLY..VFECVELELuLKLAosE-E.h.-sDFoCPI+L+RDPICppRYHCTHsAGVHSVGLoWIs+LcKFL-S-EEDKDSLQELAoEQ+ChVEHILCTKPLsscpPuPVpGFWIlsDl.LGAoMICITuoaECIuLPLLool+PsSPPLLCo+hDs-Vspp..+hLAEossSFEcHIRoILQRSVsNPlLLpSu-KDSSPPPcECLQLLSRATQVFREQYLLKpDLA+EEhQRRVKLLpsQKEKQLEDlphCREERKSLoEsAE+LAEKFEEAK-+QEsLlNRsK+lLpSh+oQLPVLS-SERDM+KELQpIs-QL+HLuNuIcQVK+KhsYQ+++Ms.uscSP+KsolTLs-+Q+KsIpsILKEpGEHIccMlKQIKcI+NHVuF	......................................................................................................................................................................................................................................................................................................................................................................l.ph.WaP.....tsphh..hL.sps.hc.aph.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	64	88	117
+10001	PF10169	Laps		Learning-associated protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4811)	Family	This is a family of 121-amino acid secretory proteins. Laps functions in the regulation of neuronal cell adhesion and/or movement and synapse attachment [1]. Laps binds to the ApC/EBP (Aplysia CCAAT/enhancer binding protein) promoter and activates the transcription of ApC/EBP mRNA [2].	25.70	25.70	26.10	25.80	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.24	0.71	-3.90	11	105	2009-01-15 18:05:59	2007-08-02 16:02:28	4	5	86	0	69	106	0	123.20	42	88.89	CHANGED	KSLRSKa+R.KMRA.KRpKstPKELtRLKpsLu.p-....ut.lMc-lp-lsphhsscchc.Eptct-sp.......t.....pcctKM-V-sc...h....NpKTLpDpaGpYPsWhNpRQ.pKKh+tKppupK.sKsKs.....sKsls	.............KSLRSKWKR.KMRA.KRcKsAPKELsRLKphLt.hD.....uchl.MpDlp....-IATVlss+chc..cphph-tp.............ppt.....pcstKM-.s-tK...+....N+K..TLhD..paGpYPlWMspRQ.tK+LKsK+pppK..s+s+s..sh..th.....................	0	17	23	46
+10002	PF10170	C6_DPF		Cysteine-rich domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4543)	Domain	This is the N-terminal approximately 100 amino acids of a family of proteins found from nematodes to humans. It contains between six and eight highly conserved cysteine residues and a characteristic DPF sequence motif. One member is putatively named as receptor for egg jelly protein but this could not confirmed.	20.70	20.70	21.10	36.90	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.45	0.72	-3.93	8	86	2009-01-15 18:05:59	2007-08-02 16:22:26	4	3	73	0	60	75	0	90.60	44	66.03	CHANGED	FcCQLCsLouPYoYaGQKPPsopulVLLE-sYVMKDPF.......oPD+E+FLlLGS+CSlCSKsVCVGs-CSLFYoKRFCLPCVpcplpsFP.EIQp-l-K+K	..........................FpCplCslpt.apY.hGp......+PP.....s.pullhLE-sYVM+DPF..........................o.s.c+ccaLlLGucCSlCu+hVClus........pCSlFYo+RFChsCsppphptFP.clptclpK...............................	0	16	20	40
+10003	PF10171	DUF2366		Uncharacterised conserved protein (DUF2366)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4545)	Family	This is a family of proteins conserved from nematodes to humans. The function is not known.	25.00	25.00	35.20	30.50	17.90	16.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.78	0.71	-4.77	9	94	2009-01-15 18:05:59	2007-08-02 16:30:53	4	3	80	0	68	89	0	155.90	36	75.42	CHANGED	sshthPp+acphh.pKhuhaa+uLlpDYpEssh-sspsu+sRPhKAulYLolLushhhsstpNPsEssF.spLhcssspLlLVsPpppNssSstalppL.chhNpG+LR+lSLGlhSllahssaDcssslYpAhC.alps.tahshacRllDVGFhG+WWhLcpKMhDYDlNp-	..................h......thatth.....stah+sLhpDYt-ssh-ssttspt+Ph+AslYsshLuushhshtpsPsEtsFpp.tLlcsospLlLlusthRN.pSptalppL.hhhspGpLRalsLGlhSLla.ssaDtpsslYpApCpYLps.pahsF.pRllDVGFhG+WWlLpt+McDaDlNp.......	0	27	31	52
+10004	PF10172	DDA1		Det1 complexing ubiquitin ligase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4816)	Family	DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system [1].	21.00	21.00	21.20	21.30	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.18	0.72	-4.15	11	148	2009-01-15 18:05:59	2007-08-02 17:01:35	4	2	101	0	93	145	0	62.20	44	51.23	CHANGED	cFLpsLPs.sppNFS.h..ssss.psostRssVYlPT..cshP.s-QlIsT-ppNILlRaLpQph-cK	................cFLpGLPsascuNFSphpss...sss..ps....SspcsuV...YlPT..cshP.............s-Ql...IsT-p.TNILLRaLpQph-KK..........	0	23	46	72
+10005	PF10173	Mit_KHE1	DUF2343;	Mitochondrial K+-H+ exchange-related	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4539)	Family	The members of this family function as mitochondrial potassium-hydrogen exchange transporters. The family is part of a large mitochondrial KHE protein complex.	22.50	22.50	24.30	25.20	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.38	0.71	-4.44	47	180	2009-01-15 18:05:59	2007-08-03 11:32:18	4	3	162	0	133	170	3	185.80	32	61.97	CHANGED	+lhl..lPlos...........+.+s.........hlY..spphp...t....................................phhphhs+lssKAucs....Wsphppucpu....a....pp+llsaGp+lLp+lPaEEhuLKSl.....Pshsp.h+phpp..........................................................ttp..........plplhaP....sslpspplhspL.+plupcptthH++hhhhshlshPlThPhsLlPllPNlPhFYlsYRuauHa+AhpGucHLphLlc	..................................RlhllPlos.................+.+s.....hlY..spphssh.h....................................tpt.shhctlssKuucs....WsphccupcG....a....p++lssaGp+lLpRIPa-EhuLKSl..........Pshss.h+p.p.t...............................................................................................p................tlpllaP....shlss..........pplhphL.+plspcppthH++hhhhsllshPlThPhsLlPl.......lPNlPhFYlsYRuaSHa+.....AltGuc+LphLl.................	0	43	82	117
+10006	PF10174	Cast		RIM-binding protein of the cytomatrix active zone	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4809)	Family	This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion [1]. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains [2].	35.00	35.00	35.30	35.40	33.50	34.90	hmmbuild  -o /dev/null HMM SEED	775	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.79	0.70	-13.90	0.70	-6.49	7	395	2009-01-15 18:05:59	2007-08-03 11:45:35	4	15	88	0	216	377	0	443.00	33	71.08	CHANGED	LpupLcps.pEpE.L+pEhEhppocLspohsplcp..........................................................hhSsELc+-+.hRccEuuclshh+pphchsptpst..+hQ.phptLQpcL.+.Qt-lp+Lhpp..pusschtp..................h-hs.tt.pRlptE+-ttth-L.hlR.....c..ohEchpLphEp.pppLssts-plcKLhEhL.....................................................Kupppsppth+RhtEt-sphpcLEslL-p+EKpp.hh..........................plHp+hphp.DsAtTc.............A.QplI-.KDop.tphE+hLcc...hpsEl.hLpSpsshupt-Rpc...plEs.+SthtthKs+................hDpst.pLuRpc........cLEshspptsDh.+p+l-hLppsLpttppctshLQsEl-tLphcL-cpcshhsKpotplpshpEEtuphusEIcch+-hh-hpptclphLQcp.....-.phpccp+phpp.p-Rl+p............ppl-cslhEhE+hht+lcp.Rpptpp.ctEph-paKcchcplcpclpshptcLpEpphpL..h+tcsspLhSst.KpcochcphcIthEpt+-cppKL.pplc+........p.psphspphstlctsssthps-sttspsElDRLh-hLccs.pp+ssp-hchucLtp....sph+hscQpcssts.....hhhp.......c+hsAphhc.hcR......cc-slppuspp..........................................pplpcL.ushcplttEh-phhhpLppoQp.LhphppcLsshcsEhp+phEEshchK...QpAhlAAluppsuphAhhEhpu.pKchsp-chtthcpE+-..........................+lVcQ.K...p.......phQpRMpL	............................................................................................................................................................p..ts..t.hptpht....p.t..................p.t.....ht.tLppcL..+.......ph......................-....t..th..t..-..-p...-h.hhp.......t.phcchphphpp.pp..ph.thppplcpL.-..................................................................................................................................................................................................................................................................................................................................................................................t.ph............p.....p...t..ptchth.p.p.tt.ptp.t.h.sp.............h-tht.chcptpt..tphtt...th.t-ht.h.t.clpc...hhp.hc.tp.ch..h..tp......p.h..t.........p..ctp.h.....th...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	59	80	165
+10007	PF10175	MPP6		M-phase phosphoprotein 6	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4531)	Family	This is a family of M-phase phosphoprotein 6s which is necessary for generation of the 3' end of the 5.8S rRNA precursor. It preferentially binds to poly(C) and poly(U).	25.00	25.00	25.20	25.00	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.49	0.72	-3.65	6	144	2009-09-11 06:05:00	2007-08-03 13:18:23	4	1	114	0	97	135	0	102.40	40	63.94	CHANGED	LSKulLcMKFMpRs+-pl-Kcts-Ecp+t...LhSsE...lstchLppoppall.EsSal.C......EsLl.GRlSFtGhNPElE+LM...........E....p.pAt+....puctt-cpscth.....DVsDpEMA	....LScsLLcMKFMQRsh...-pppKcp..h..-.E-c+c........l...huc..E.............l..shstl...p....ppps...a..ll...Ep.Sah.C........-sL.l.h.......GRMSFpGFNP-l.EKLM.....................php..sc.p........p.s..ct...p.cp.p..hth......DVoDpEMA....................................................	0	29	40	69
+10008	PF10176	DUF2370		Protein of unknown function (DUF2370)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4812)	Family	This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.	22.60	22.60	22.90	23.30	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.72	0.70	-5.02	26	493	2009-01-15 18:05:59	2007-08-03 13:29:02	4	7	220	0	283	488	0	134.60	24	66.36	CHANGED	phstlssh.......p..sst.ut...thGtusDGVFsNLsAK...P-p.................tttppphPPoY-pAAADssPsYa-sshhssu.................hhtDElhl-GLPVGshhsFlWNhhlohsFQalGFLLoYlLHToHAA+pGSRuGLGLTLlpaGahM+sus.....................t.tts.thh...s...................Pssap...........p.....t....suaps.........................htsp.WluahlhhlGhhIhl+ulhsYh+l++hEchlLpsssppt	..........................................................................................thh...................................................................................................................P.P.....sYp.st.t................P.Y.t.ph.ts..............................................................................s...hp..th.....l....Gs.h.Fhhshh.huh.Fp.hlGFhh.hhhppohAu+.Guh.GhGlohhtahh.hh.t................................................................................................................................................................................t..hh.hhhhhhGhhh.hpuh.ta..hhp.............t..................	0	66	110	190
+10009	PF10177	DUF2371		Uncharacterised conserved protein (DUF2371)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4823)	Family	This is a family of proteins conserved from nematodes to humans. The function is not known.	22.90	22.90	23.10	24.20	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.88	0.71	-4.30	10	150	2009-01-15 18:05:59	2007-08-03 13:41:28	4	3	78	0	102	135	0	130.10	39	32.60	CHANGED	RQDSLRSp.p...........tstc++......+s+++p+u..-VVVVRGKl.....+LhSsSGhhllLGlllllVGlAMAlLGYWP+................................................ttt.tsttss.opspssshpspst.Gshs+hhppaLHS-+hKhLGPllMGIGIFIFICANAlLHENRD+cTKlIshR	.........................................................tph+.......h+h+.+s...cVlVV+GKl.....+LhS.SGhhhllGlLlhllGh.....uMAVlGY.WPp......................................................tth...s..ts..t.spt..hpsps...uhhh+.hhptahHs-+h+hlGPllMGIGlFlFICANslLaENRDccTKll.hR........................................	0	19	28	60
+10010	PF10178	DUF2372		Uncharacterised conserved protein (DUF2372)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4828)	Family	This family consists of proteins found from plants to humans. The function is not known.	21.20	21.20	21.20	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.79	0.72	-3.85	8	121	2009-01-15 18:05:59	2007-08-03 13:49:53	4	3	100	2	79	102	0	89.10	34	62.90	CHANGED	lVlTQhGKhGTllslp........s.spu-.........lspPsaoscV......LLGp.D-Plh+lhA+pLlstlutEsus+sllLuluLKD+Ss-sLKsltcslcpspl	..............................VllTQhGKhGTl.lslp...............s...tts-....................hscPshsspV......LLGp...D.EPLlcl....hA+....pLlpal..ot......p......uu..s...+sllLuluLK.D+Sh-sl+slhpslpps.........................	0	21	34	53
+10011	PF10179	DUF2369		Uncharacterised conserved protein (DUF2369)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4806)	Family	This is a proline-rich region of a group of proteins found from plants to fungi. The function is not known.	20.00	20.00	20.00	20.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.28	0.70	-5.31	5	148	2009-01-15 18:05:59	2007-08-03 14:07:11	4	5	72	0	105	142	0	226.20	31	59.39	CHANGED	sRhplsTIV......................ClGp+NpplVpG.L+sDoTYalDVFulcppRsoSSAYluootpT....................+cpsRouPltLp-GpLtQVcLcs++G....hKFFsFslPp..tssusQospLlVHsCsGs.VRlpLFRsGKLLt+o.tuFpGhRpFsVsul+PGc+YLlRap.sNDDEuh+TlRVh.AsSTcuspuPaPsLP-DToVKhls.hRoCSSATIAWhuopDc+.lKYClYp++psoNahE+pVsctsNhCpGslS+clh.....p.VsChYsHSPsps-.pscSlhppTIuNLtPuSTY...LLsVssstssG+uLPYRolhV+TssYC	..............................................shh...............................Chstpp..hl.t.h..pppY.hslashp..pt..shhh.st...p......................tp.......h.Lpptth..h.ltttts.....t.hpht.........p..hhhhl.sC...s...lp..lpl...ptp.lhpt...h.t.t.h.......................ps..stthYhlcl..............s.spc.t..sot.........hKlh...sTTt.scpsaPpLPpDsR.................lcshshhRpCoolTlAWh....so.-.....+....p....pYClhhpc.cs.p...........s.C.......pp.............h.C....p...................pth...hl.tL.sut.Y...hh.lhh.h......u.sl.Y..hhl+ht..C....................	0	15	27	66
+10012	PF10180	DUF2373		Uncharacterised conserved protein (DUF2373)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4829)	Family	This is the C-terminal conserved region of a family of proteins found from fungi to humans. The function is not known.	25.00	25.00	28.30	27.50	19.30	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.23	0.72	-4.43	26	219	2009-01-15 18:05:59	2007-08-03 14:32:39	4	6	203	0	158	217	0	68.90	35	21.80	CHANGED	LpYLppatps+ps....................................WKFsKp+QsallKahhs.-clPpcatshLlpYLpsLpG.suRp+Lhcpucpll	..................................................LpYLppatps+ps.........................................WKFpKs+QsaLl+phas..-.clPsp.ahshLltYlpuLpG.suRpclhppApph........	0	48	84	128
+10013	PF10181	PIG-H		GPI-GlcNAc transferase complex, PIG-H component	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4551)	Family	PIG-H is a family of conserved proteins that complexes with three other proteins to form the GPI-GnT (glycosylphosphatidylinositol anchor biosynthesis transferase) complex. It appears to be a peripheral membrane protein facing the cytoplasm involved in the first step in GPI anchor formation.	20.50	20.50	21.10	20.60	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.98	0.72	-4.34	33	259	2009-01-15 18:05:59	2007-08-03 15:55:35	4	8	226	0	173	243	1	69.60	33	28.05	CHANGED	Sllll+slGlQlsop......hh.spt..............pcFIPhscIhDlVIsEuF.psa.pVhaYLslll.........+spsp...............lhllF.p	.............................ollllculGlQhoop.......ahsupp..................................pspFIshscIpDlVINE..uh..phh.pVhaYLslll.........cspsc...............llllF.............................	1	47	89	139
+10014	PF10182	Flo11		Flo11 domain	Linder T, Bateman A	anon	Pfam-B_18862 (Release 22.0)	Domain	This presumed domain is found at the N-terminus of the S. cerevisiae Flo11 protein. Flo11 is required for diploid pseudohyphal formation and haploid invasive growth. It belongs to a family of proteins involved in invasive growth, cell-cell adhesion, and mating, many of which can substitute for each other under abnormal conditions [4].	25.00	25.00	27.50	27.50	21.70	24.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.81	0.71	-4.65	14	112	2009-01-15 18:05:59	2007-08-03 16:57:57	4	12	42	0	73	110	0	141.30	29	19.18	CHANGED	stssphshs.phtstshPthslsVpsVpaVtsNhYpVTlpapsspshsLppL......ppLpIlGlsssp.....sshhLautsps.s.lIs...NsscaouThhVtup....sssshhChP.sFpIpa-aspssssph..sssWp..hhspsashhhuCss.ssptp.uppshssa	............................tppsh.ph.s.h.slpsVpalp-ssYplTlphpupps.l.sL.c..L......tuLKIhGlsuPp.....tsh.Lautspp.shhI.s...sPscaosoap.....Vhup.....spsspshhP..sFpIpa-ahpusu.sph..hpsWp...hGsssas..h.sGCpt.sp....uphsh...h.........................................	0	7	32	66
+10015	PF10183	ESSS		ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4808)	Family	This subunit is part of the mitochondrial NADH:ubiquinone oxidoreductase (complex I). It carries mitochondrial import sequences [1].	22.70	22.70	22.90	23.00	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.45	0.72	-3.63	45	270	2009-01-15 18:05:59	2007-08-03 17:16:03	4	9	222	0	169	257	0	102.20	25	65.39	CHANGED	htpspt.........st..ssssupts..u+tp...............Ps................Gh......LascpP...G.....pphchEsWEhsaahuhhhslVlhulshsaK.P..Dhol.poWApcEAt+R....LEscG	..........................................................hht....................pss.s.ps.....sctt....p.........................sp......................uh.........Laspp..P...G.....pphchcsWEhsaahuhshsllhhushhsap.P..Dh...........s...........h..psWApcEAhcc....hEttt......................	0	53	87	131
+10016	PF10184	DUF2358		Uncharacterized conserved protein (DUF2358)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4457)	Family	DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.71	0.71	-4.15	29	393	2012-10-03 02:27:24	2007-08-06 10:34:44	4	5	158	0	238	556	155	112.80	25	44.24	CHANGED	tcllchL+pDhspha..scshsYuIYscDlhFpDPlspFcs..lppYphh...l+Fhsp.aFtslpl-lpclppssp....pIpsRWsl.pshshlP.....W+...scls............hsGhSphplspsG.hIhpH	.........................t..hhchL+p-h..s..p..ha...hps...hs..h..s.lYspDlhFt.....DPl........t..sacG.............hppYpt.........l...chlsp.ha...........t....p..hpl-.lhpl.....p.......p......ts......cs.......slp..sRWpl..ps.h..s.t.hs........Wc......scht.........................hsGhSpahlsp.pu.hIhpH................................	0	84	158	207
+10017	PF10185	Mesd		Chaperone for wingless signalling and trafficking of LDL receptor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4357)	Family	Mesd is a family of highly conserved proteins found from nematodes to humans. The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs) [1]. The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation) [2].	19.20	19.20	19.20	19.90	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.92	0.71	-4.53	7	123	2009-01-15 18:05:59	2007-08-06 10:54:47	4	4	99	12	84	133	0	158.90	44	78.42	CHANGED	tKKDIRDYsDADhtRLLEQW..E--DslE.s-LPEHhRPssslDhSplDs..ssPEslLKhSKKG+TLMhFVoV..oGsPTccE....TE-ITpLWQsSLaNsphphpRallssNRAIFMh+DGu.AWEsKDFLVpQ-RCtcVTlEsp.YsGKs..............................tp.tpsK-EL	......................................................tKKDlRDas-ADhtRLL-QW...EcD-.slE-s.-LPEH..hRPs....s....lD.h.Spl..Ds.........spPE.slLKh..oKK...G+T..LMhF.VoV.....sGs.P....Tc.....cE....oE-ITpLW.QsSLaNs..p.hplpRahVsssRAIFMh+DGu.AWEhKDFLlpQ-RCt-VTlEspsY.sGhs..............................t...................................................................	3	26	36	62
+10018	PF10186	Atg14	DUF2355;	UV radiation resistance protein and autophagy-related subunit 14	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4398), Wood V	Family	The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway [1]. There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localisation of this complex at the PAS is controlled by Atg14 [2]. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex [3].	27.10	27.10	27.10	27.20	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.95	0.70	-5.47	39	520	2012-10-03 11:38:54	2007-08-06 10:55:36	4	16	250	0	371	532	2	295.80	16	56.42	CHANGED	pCslCp....sspp.hhCssCsps...........p...Lhch+hchtplttcp-slpp+lpphlp...............................sththpth+schtpppc+hpplppplppl+pclcpp+pclpph+pslpp++sslp...tp.thtpccsp.lpphpsshc+tcpphpt.lpshhtppRshlhcplsplaslpph....................cpss........ptsas.Iu...s...........hslhsh+shpp................................................................hssppIssSLsahspllsLluchLulcLPtplshs..ppsh......................................................................shsths.cp.......stshppFhculshLshNlsaLsp........op...ulsls...hssa-shsplhp.lhphhhsp	.....................................................................................................................................................................t.....h.php.thtphh.pp...pp...lt...pplpphlp.....................................................tp.thpphptphtp.t...p.+ht........l.ppplpp.ppplppt.ppplp.chptplpp+pptht.......tt....th........p.pttp..thp..p..h.pp.p...h..p..pp......cph.h.......p.........p..hppp......htt...pppp.lhp.p.lst...laslp..............................................p.ts.............................ptsas..Is..............s............................htl..s.s...s...p....sh.ps......................................................................................hst.t...plu..s...u...LuasspLlpllu.hhL..slsL.a.lt...h....t.pup..........................................................................................................................................................................................................................................................................t..h......t................s.s.p.....pFphulhhLspslt.Lph...............pp...slph.......p..hpsh..hh..........h....................................................................................................................................	0	111	180	293
+10019	PF10187	Nefa_Nip30_N		N-terminal domain of NEFA-interacting nuclear protein NIP30	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4036)	Domain	This is a the N-terminal 100 amino acids of a family of proteins conserved from plants to humans. The full-length protein has putatively been called NEFA-interacting nuclear protein NIP30, however no reference could be found to confirm this.	21.60	21.60	21.60	22.50	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.59	0.72	-3.84	17	264	2009-01-15 18:05:59	2007-08-06 10:57:05	4	4	215	0	181	250	1	97.20	39	42.18	CHANGED	FVSpupl-E.+c.ttp.ht.......tcpscspsppp.cu+oLYEhLQppK.ctKptEa-Ep...hKlKN.h+uLD-DEsEFLDplpppc+ttEtphccEEscpLctF+	......................................FVSpuplpEt+cpc.pEthcthpp..........scsspt.ps.pcthD...sRSLYEpLQcp..K..spKQpEaEEp...hKhKN...h.............RuLD-DEspFLDplpcppcthEcphccE-tcpLcpa+..........	0	62	95	145
+10020	PF10188	Oscp1		Organic solute transport protein 1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4033)	Family	Oscp1 is a family of proteins conserved from plants to humans. It is called organic solute transport protein or oxido-red- nitro domain-containing protein 1, however no reference could be find to confirm the function of the protein.	25.00	25.00	52.20	52.00	23.50	20.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.98	0.71	-4.44	10	139	2009-01-15 18:05:59	2007-08-06 11:10:40	4	3	104	0	83	133	3	170.40	48	48.65	CHANGED	MlYlL-QRL+AQs...lsp-KuspVLcDIspslasscFlsELFpspt.....lhShstl+plhcslupCSIMRLspsSMsKLaDLMhMshKaQlhssp+PtEllp.lThsHL-ulpcllsp...sctpshlctshpplh-hassLsss-hhtlRpcLLsFLpshps+VSlhlcsshQs.psGsFhl	.....MLYlLDQRL+AQs...IssDKu..........c+...........VlsDIlssMFscKFh-ELFKPQc.....LYScculRola-+LAHuSIMRLNpuSMDKLYDLMTMuFKYQlhlss+P+-lLh.lTaNHLDuI+s.hlpD......ssslhppVDp......shppL...h.........-hYu.sLosG-athIRpTLLhFFQDh+lRVSlFL+cplQs.ssGpFl......................	0	29	41	63
+10021	PF10189	DUF2356		Conserved protein (DUF2356)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4262)	Family	This is a 200 amino acid region of a family of proteins conserved from plants to humans. Some members have been putatively annotated as being integrator complex subunit 3 but this could not be confirmed. The function is unknown.	25.00	25.00	30.10	36.70	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.48	0.70	-5.30	8	130	2009-01-15 18:05:59	2007-08-06 11:12:43	4	3	105	0	95	130	0	216.70	53	24.43	CHANGED	pLWRDllh...............pPpshsPta.GlhQLhch+TS++FLt.sRLoPEMEpKlhFlhusVKFGsQK..RYQsWFpcKYLsoPEScSLhsDlIRFIssVlHPoN-lLsSDIlPRWAIIGWLLooC.........................psssspuNuKLuLFYDWLFFDPcKD.NIMNIEPAILlMhaSl...............+paPtlTsoLL-FLC.+lhcsassptc-pIRpGVpNuh+hIh-KtVl.sLs.lh-ssKL-R-Lp.hlRcpFs-FLS	............................h.LW+Dllh....................NPpsL.s.P.pFsGlhQLLptRTSR+FLt.sRLTP-MEpKLhFh.sSpV+FGpQK...RYQDWFQ+pYLuTP-SpSLRsDLIRaICuVlHPoNElLsSDIlPRWAlIGWLLToC.........................Tosl.A.suNAKLALFYDWLFF...sPcKD.s.IMN.IEPAILVMtHSh...............+sHPs.lTsTLLDFhC.RllssFaPs..hcsplRpGVhsSLphIl-Kp.Vl........spLsPLF-s.P....KL...D...+-LRshlRcpF.EFh.....................	0	35	48	71
+10022	PF10190	Tmemb_170	Tmem170; 	Putative transmembrane protein 170	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4349)	Family	Tmem170 is a family of putative transmembrane proteins conserved from nematodes to humans. The protein is only of approximately 130 amino acids in length. The function is unknown.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.48	0.72	-3.97	8	145	2009-09-11 14:34:23	2007-08-06 11:13:35	4	3	91	0	98	132	0	98.90	53	67.44	CHANGED	LssFsEMWYaVFLWALFSSlFlHssAullAFsTLR+HKhGRF.hSIhIllMGlLuPloGGllTSAsIAsVYRAuGhsMuPlcAllaGVGQTllohllSFoRILATL	..................psasEMWYt.lFLWALhSSlFhHss.AGlLAhhTL....R+H.KhG....Ra..hSlhl....llhGhlu...slTuGhlTSAAlAGVYRuAGKpMhPhcALshGlGQThhslllSFh.RILATL.................	0	22	33	63
+10023	PF10191	COG7	DUF2354; 	Golgi complex component 7 (COG7)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4182)	Family	COG7 is a component of the conserved oligomeric Golgi complex which is required for normal Golgi morphology and localisation. Mutation in COG7 causes a congenital disorder of glycosylation [1].	29.30	29.30	31.10	30.90	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	766	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.31	0.70	-13.21	0.70	-6.63	8	242	2012-10-02 15:56:29	2007-08-06 11:14:02	4	7	143	0	166	238	2	481.30	21	88.41	CHANGED	DhSpFuuDcFDVKcWlNAua+uspcssuss+sct..aluoLVhKLQLalQ-lNsulEEoStQALpsMP+VlRDlptL+pEAuhL+-pMttVpp-Ip+hEp-TupsMpsLsRlDsVKpRMQhAtcoLQEADGWupLSA-lEDsFcosDlsssupKLsuMQpSLuAls-lP-aoE+psQLEsLKNRLEALsSPplVsAhsspsl.......DQupcaVpIFpcIsRhPQLptYYpKlHKs.LhphWpchspppts.........................hshsphLopFYDpLLphhcsQh+WssQlFpc.hc.llsllll-TLusLsPShsuplspAlc+Ass-.c........................LpsLl-lassousFu+slEphlttt.tp....ssLh+lh-LlcAVauPacsFptpYGsLEcopLptpluulslctu..........ElsDsVpcL-cSlsKlhsLhpuAV-RClshTsGhulspLlpALculhtpYlopaspsL+SLRhspsl-shssss......................E-WSlhQsolplLsssG-LhppsusFEppLtsplhshuuph..p.assp..ts..p....tppuss+sshptaphlspschs-hsshhcsLhslpEcu..........................................ssshslLutsppsls+hsppsH-LsaDslF.pI+QpLtpl.s+hcsaootultE.hs.DLPsFShsPQEYITsIGQYLLTLPQHLEPLlpu.sssLchsLcssch.assppttt..-hpshADhWLuplAEuopthYp-pIhpIptLos+uAKQLATDIEYLuNVL-ALGLslstsLQpIlTLL+As.-pY+sluK.....uLsh+LuusIsphRs	...............................................................................................................................................................................................................................................h..th..h........................................t.........h.t.......l.p...lp.hptchp.s.ts.Lp.cuttht....t....h.tpl......pt..hh.........t.......t.......t.......ph................................hsttl.thppsh.h..........t.hs.th.tt.h...ht..hppp...lct.hp......l....ht.ht....t.t...................................t.st.hh...tlh......th.tp..th...a.t..............h....W...t.....................................................................h....hht.hh..http..........hh........................h....h.......h....h......h....................................................................................................................................................h...............................................t.h..............t.s..tph..ho...t....h.h...ht..h..............................................................................................................................................ht.h.t...............................................................................................................................................................................................h.........th.......h.t....hh.p.h....h..h...h..h.....................................................................h..st..hs...............P.t.hpphuphlhsls..h-sh..........................................................................................................................................................................................................................................................................................................................................	0	85	110	141
+10024	PF10192	GpcrRhopsn4		Rhodopsin-like GPCR transmembrane domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4290)	Family	This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers [1].	23.70	23.70	23.70	23.70	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.29	0.70	-5.19	23	259	2012-10-03 04:04:29	2007-08-06 11:14:50	4	6	114	0	206	328	2	222.60	26	48.39	CHANGED	shplcaclplhNss.........t..spcFSh-ppsl.phhhlhhllallhlhhshhhh.pthpppp.hchshphhshslhlphlShhlhhhahhhYu.hsGhGh.hhplhupllphhuphlhhhLLlhLuhGWTIop.hphs........shhhhhslhsllshhpsllhlh.sphhh-stppha.Y-uhsGahllhl+lshhlaFhhultp.sh..p+ps..t+psFhhhFshhshlaFluhPllshluhh.lssahRtKllphsshhhphluhlhh	............................................s..plpachhlhNsp..........s..hpcFSh-c........slhph..hhhh..l.lahlhhhh...h..h...hlptpt.hHssh.+.h..hh.s.u.l.hlp...hhShhh.hla.hhp.Yu.tsG.lG..................hthhucl...hphhSphh.hhhhLl....hL.u.hG.aols+..hph.s.......................st...h.hhshh.shh..sh.h..p..hhLhla..........t...p.....-s..t.p..sh........atac...o.sGhh.ll..h......lpl.shh......l.h.F...hhslh........h.....c+.s..........KptF.....ah.F.h.h........sh.hlW..FhshPl.h.shl.u.h..hst..ahRt.+llp.hh.hhhph.huhhlh....................................................................................................................	0	93	119	170
+10025	PF10193	Telomere_reg-2		Telomere length regulation protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4346)	Family	This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.	20.90	20.90	20.90	21.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.36	0.71	-3.82	31	272	2009-01-15 18:05:59	2007-08-06 11:15:43	4	8	242	4	200	275	5	111.50	31	12.69	CHANGED	sPlYl+DLlphLp.-s.ps...h-+hchALpsussLIRpKss...assElpphup-LsphLlsLps.pachppFp-hRhpuhlAllVsp...............................P.phupahsphaas..u-aSlpQRhslLssLuhuA	............................PsYl+DllphLptsp...s........h-+hchALpss.s.LlRppss......-lpchut-LsphLlpLp.....s.....chshssFpphRhpuhlAllVsp....................................Ph.psupals.pthas..sshSlpQRhslLssLuhuA...............................	0	65	108	163
+10027	PF10195	Phospho_p8		DNA-binding nuclear phosphoprotein p8	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4319)	Family	P8 is a short 80-82 amino acid protein that is conserved from nematodes to humans. It carries at least one protein kinase C domain suggesting a possible role in signal transduction and it is thought to be a phosphoprotein, but the sites of phosphorylation and the kinases involved remain to be determined [1].	21.20	21.20	21.60	21.30	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-8.92	0.72	-4.09	13	132	2009-01-15 18:05:59	2007-08-06 11:19:25	4	2	94	0	67	134	0	57.90	46	70.61	CHANGED	MSEsaaD-aEaYNacpDKtlhoG.tSGKtRTK+EushHTN+hsPuGHsRKllTKLpNoEpK+	............p-thhDpa-hYshst.ph.hhu.G..uuKtRTK.+EAut+TN+.sP..uGHpRKlloKL.N.oEp++....................	0	18	22	40
+10029	PF10197	Cir_N		N-terminal domain of CBF1 interacting co-repressor CIR	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3869)	Domain	This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.62	0.72	-3.93	39	495	2009-01-15 18:05:59	2007-08-06 11:23:05	4	9	268	0	353	481	1	37.10	38	10.07	CHANGED	SWHPshh+Npc+VWcsEQcthpEp++lc-hpc.EhccE	.uWHPtshcNhc+VWtAEQct....ptEcKKh--htp.chpcE................	0	116	185	289
+10030	PF10198	Ada3		Histone acetyltransferases subunit 3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4191)	Family	Ada3 is a family of proteins conserved from yeasts to humans [1]. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage [2].	24.50	24.50	24.70	25.00	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.71	0.71	-4.40	23	232	2009-01-15 18:05:59	2007-08-06 11:23:59	4	2	212	0	178	230	0	133.70	32	22.73	CHANGED	phDasolEERLK+EL+alGlh...................................................Dss-h...ss+pDDElsAELRpLQscL+plophNptcKp+LlslscEchAaQEYpsIL--LDpQlppAYhKRl+shtK+K+...pc+pst.................ptpAssu..................sL+sLL-+	.........................................chtslEpRlKpELhthGlL................................................................................-...s.Dh....sscpDDElhucL.RphQsEL+p.sthNps+KpcLlc..ls+EchuhQEhpph.l-slDspV.pAYhKhhpshtK++p.....p+ccts.....................tt.tshpt.................tc.hhpLh-......................................................	0	58	94	145
+10031	PF10199	Adaptin_binding	KYY; 	Alpha and gamma adaptin binding protein p34	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4273)	Family	p34 is a protein involved in membrane trafficking.  It is known to interact with both alpha and gamma adaptin [1].  It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane [1].	32.00	32.00	32.00	32.00	31.90	31.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.85	0.71	-3.89	38	207	2009-01-15 18:05:59	2007-08-06 11:24:57	4	5	184	0	156	211	0	139.40	22	39.17	CHANGED	EppGhc..RlhEsL-sp.Wss.hc.tp.t...............................................................................................................hppcthshcps.pphp...................................................................tt.p.-...............shEplhp+lpth+cpspp..lsc......pcRccaAtchspc	.............................................................................EppGlpRlhpALpup.Wss..hthcstpp.........p...t.........................................................................................................................................................................................................................hptphtshpts.pptt.....tt............t.......t..........................................................................................t.t.tp..s....psphcl-...........................shEpLhp+lpth+-puss..LPc.ppR+phAtKsstt..............	0	52	82	125
+10032	PF10200	Ndufs5		NADH:ubiquinone oxidoreductase, NDUFS5-15kDa	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4110)	Family	This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain [1].	21.20	21.20	21.30	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.22	0.72	-4.00	6	171	2012-10-02 15:44:21	2007-08-06 11:25:25	4	4	139	0	105	165	0	82.40	31	76.86	CHANGED	MPFlDlQK+LGlNlD+WlhhQSuEQPaKhAuRCHAFEKEWIECuHGIGpTRAcKECKIEaEDFhECLhRpKTM+RLpsI+cQR-KLlKEGpYTPPP	....................................................sRCasFEpcal-C...s..c...uh...G...t..s.Ru...c....KcCphth-DahEClp+pKphpRhpslp....p....p+c+...t........................	0	29	51	81
+10035	PF10203	Pet191_N		Cytochrome c oxidase assembly protein PET191	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4114)	Family	Pet191_N is the conserved N-terminal of a family of conserved proteins found from nematodes to humans. It carries six highly conserved cysteine residues. Pet191 is required for the assembly of active cytochrome c oxidase but does not form part of the final assembled complex [1].	22.90	22.90	23.10	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-9.76	0.72	-3.93	33	259	2009-01-15 18:05:59	2007-08-06 11:26:49	4	5	238	0	182	235	2	64.60	39	59.86	CHANGED	hssSCpcl+psLttCL.cScClhhccposc-CLpss...tplPpcChtl+cuah-CKRuhlDh.RpRFRGN	.....ssuCpsl+psLstCL.pS-Clhhp.c..+..oPp-CLcps....plP.cCptL+puah-CKRuhl....Dh.RpRFRGp...............	0	50	89	144
+10036	PF10204	DuoxA		Dual oxidase maturation factor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3921)	Family	DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases.  DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites [1]. It is conserved from nematodes to humans.	21.20	21.20	21.30	26.90	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.83	0.70	-5.34	7	173	2009-09-11 16:49:30	2007-08-06 11:27:08	4	3	80	0	103	157	0	229.80	42	73.87	CHANGED	Pa..ssRsshshsspllslhllFlshhluFLlILPGlRt+............................RhhhhhpllLSLFlGAVIlssphsssWtsup.hhhssYKuFSpphl.AclGhalGLhtlNlTLt.........uhPstphsE.sIsYNEtFsWctspshscpYccALE+GLP.PlLhVAEhFohs.sshuhhpQYRhAGaYASthLWsuFssWlLhNlLL..hsVshYGuhhhhh..TGhhhLhuhhsat.h...hpsssl+lu......suVlph+.aGhsaWLsLssGlLCl...lsGlslslhchshP+slpshlphu.cps	.....................ah.ts+.shshssshhhllhlFlshhssFllILPGIRG+.............................Rhhhhl+VhhSLFlG.......AhIl...ss.phuspWtsu.p.hp.h.ssY+uFStthl..AclGhplGL.tlNlTLp.................................uhP.h...tp.........h.s....-....sIsYNEpFsW............p..........h...........s....p..........s..........hsppYtpALp+GLP.PlLhlAEhFo.p...pshshhtpYRhAG..aYsuhhLW................sAFhh.WlltNlhL..hss.hYGuhh.hhh..TGhh.lhuhhhas.h.s.h.....h..slpls................suhLphp..aG..sFW.ls.LssGlLCh...lhGhhhshhchh.Ppthpshhp...t..s..........................	1	29	35	67
+10037	PF10205	KLRAQ		Predicted coiled-coil domain-containing protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4421)	Domain	This is the N-terminal 100 amino acid domain of a family of proteins conserved from nematodes to humans. It carries a characteristic KLRAQ sequence-motif. The function is not known.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.24	0.72	-3.98	7	131	2009-12-22 15:39:10	2007-08-06 11:27:39	4	5	89	0	81	123	0	96.40	53	16.16	CHANGED	QKLApEYSKLRAQspVLK+AVl-EQupssuL+EpLKpK-poLR+hpQEhDSLuFRNpQLt+RVp.LQpELt.....lscstspKs+..ssscpsu.huppspsVhcE-L	.....QKLApEYSKLRAQspVLKKuVl...-EQApss........uL+EQLK.KDQSLRKhpQEhDSLoFRNpQLsKRVElLQ-ELs..........ls.Es+..uKKsK....csucs.suphstpptsVhtE-...............................	0	29	36	62
+10038	PF10206	WRW		Mitochondrial F1F0-ATP synthase, subunit f	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4092)	Family	This is a family of small proteins of approximately 110 amino acids, which are highly conserved from nematodes to humans. Some members of the family have been annotated in Swiss-Prot as being the f subunit of mitochondrial F1F0-ATP synthase but this could not be confirmed. The sequence has a well-conserved WRW motif. The exact function of the protein is not known.	26.50	26.50	26.50	27.40	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.38	0.72	-3.98	17	197	2009-01-15 18:05:59	2007-08-06 11:28:26	4	8	102	0	96	213	0	84.90	43	59.95	CHANGED	MuhGthPucaNsKlpGsY...paYGp.DpPhhpVKLGELsuWhuRR-KoPpuhsuuhSRuaWRappKYhp..sK+sGIushhpllsuhhshhYhhsYs+lKHaRph	..............................h..............................tDpp.Lh-VKLGELsuWlhh...RD.hoPsulhuAhpRuaa.Ra.pKYlp..sK+uulushh...llsuhhhh.YhhsY.p+..lKHcR..h....................	0	17	23	68
+10040	PF10208	Armet		Degradation arginine-rich protein for mis-folding	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4154)	Family	This is a family of small proteins of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. Armet is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress [1].	20.60	20.60	20.70	20.60	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.17	0.71	-4.56	8	204	2009-01-15 18:05:59	2007-08-06 11:29:04	4	12	129	6	120	194	4	131.40	47	65.87	CHANGED	-CEVClcFlsRhhpSL.scsVchcsDsIEctlhctCcss+GKENRFCYYlGAsp-SATpIhsEVo+PLSa+MPs-KIC.EKLKKKDuQICEL+Y-Kp.lDlsoVDLKKhKVK-LKKILs-WGEsC+GCsEKoDFIp+IpELtPKYs..tt...ps+TEL	..........................-CEVClphls+F...hpsL.sc..s.sp.h.s.ttI.Ep.thhchC.pps..+...s.........K..ENRhCYYlGuhp-uATtIls.Elo+PhoaphPspKIC.EKLKK+DuQIC-L+Y..-....Kp.l.DLs....o......VDL+KL+V+-LK+ILs-.WGEpCcGChEKoDal++IpE.LhPKYs................................................................	0	46	59	86
+10041	PF10209	DUF2340		Uncharacterized conserved protein (DUF2340)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4147)	Family	This is a family of small proteins of approximately 150 amino acids of unknown function.	25.00	25.00	46.60	31.10	19.80	17.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.67	0.71	-3.95	18	127	2009-01-15 18:05:59	2007-08-06 11:29:24	4	5	113	0	92	121	0	111.60	43	71.62	CHANGED	lTVRlIKSF.YRNlKNhlh+slDLpspTsc-Llc.l+pcIpTsuuh.RPFRsl..cYDoLKIYT+AHGSKTsNLVINh-cD-pWlL...............phpsts+oLh-hGVcNETElShFNhcDYhpaKtNPcpKW	.....lTVRlI+SF.aRNhKslVh+slsL..spTsc-hhphlppcltpp.....suh..PaRNh.......pYDTlKIhppAHuuKTssLVlsh-cD...-.phlL...................p..pspoLtph.GltsETEluhFshcDYhpaKtNP..p.pW.....................	0	38	53	72
+10042	PF10210	MRP-S32		Mitochondrial 28S ribosomal protein S32	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4106)	Family	This entry is of a family of short, approximately 100 amino acid residues, proteins which are mitochondrial 28S ribosomal proteins named as MRP-S32.\	  Their exact function could not be confirmed.	25.00	25.00	32.60	32.00	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.25	0.72	-3.67	8	112	2009-01-15 18:05:59	2007-08-06 11:29:54	4	4	76	0	66	106	0	88.40	44	60.99	CHANGED	NCsV-lAlTpDGRTIVCaHPuV-lPYEHTKPlPcsD.lpssspoHEplLKo+Lp..phKptc.tPspEELSKlFaTTKHRWYP+Gp..cR+tKpsPsccc	.............hpsclAlTSDG+TIVCYHPss-lPYEHTKPlPcss.....hpsst....ps+-phL+splp...phpphcptshh-pLuKhFaTTKHRWYPpup..pc+tp.sP.cc...................	0	17	21	43
+10043	PF10211	Ax_dynein_light		Axonemal dynein light chain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4001)	Family	Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains [2].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.11	0.71	-4.46	30	362	2009-01-15 18:05:59	2007-08-06 11:30:38	4	5	126	0	212	328	14	174.70	30	36.75	CHANGED	sc-lLsoIlPPRcap.cc.uphalQhVSssPuoRpDVlpLp-pLDppLppRpAR-oGI.CPIRcELYuQCFDElIRQVTIsCsERGLLLlRVRDEl+hTlsAYpsLYESulsFGhRKslpsEps+s-hcpclppLEc-ppcLcpplpcLct+h-shc+ptpEcpptcEKp+p-ElsaLK+s.sppL+spLcpl	......................................................................h....h...pt.t.hhhp.sS.pP...s...oR.DVlpLp-.....LD....phLp......p......p...p...........A.....+....p............o....G............I....Cs.l...R...........c......c...l..YspsF........cELIR......QVTlsCsERGlLLh+lR--........h.ph....sls....s........a....p..pL.hcu....ul....s....a...uh+c.slps...c...p.t.c...t.......chpp.c....l.tp.......L.cp.chpcLpppltchpt+.h-th.p..c..pttct...pt...........tp..cth.tpclt...h...hct.t..tphp......h..................................................................................................	0	108	131	176
+10044	PF10212	TTKRSYEDQ		Predicted coiled-coil domain-containing protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4421)	Family	This is the C-terminal 500 amino acids of a family of proteins with a predicted coiled-coil domain conserved from nematodes to humans. It carries a characteristic TTKRSYEDQ sequence-motif. The function is not known.	19.90	19.90	20.10	20.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	518	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.79	0.70	-5.58	5	140	2009-01-15 18:05:59	2007-08-06 11:33:46	4	6	86	0	85	141	0	322.70	36	59.42	CHANGED	LAGQALSFVQDLVoALLNFHTYTEQRlQIFPlDSAIDsISPLNQKFSQYLHENAuYVRPLEEGMLQLFESITEDTVTVLETsVKLKtFSDHFoSYVsFL+KILPYQLKSLEEECESSLCTuAL+ARNpELapDMK+lTAVFEKLcTYVoLLALPSTcP-GLLRTNYSoVFTQluuuLHuLHDllKElSKHYsQKAoLEQELPTATQKLlTTNDCILSSlloLTNuTGKIAoFFuNNLDaFTSSLSYGPKGuTsFlSP..LSAEsMLsYKKKAuAYM+oLKKPCP-SVPYuEALuNRRVLLSSTESREGLAQQVQQSLEKIuKLEQEKEHWMLEAQLuKIKLEKENQRIAsLlKso...puGpLsssspEsusLspuuEQsEusSscup+EPTpoTSLlGMLTlTs-sp.sPDcESRE-LIKoHYMARIAELTSQLQLADSKAVHFaAECRALAKRLuLAEKSKESLTEElKLAsQsISRLQDELhTTKRSYEDQLSMMSDHLCSMNETLTKQREEIDTLK.MASK	................................................................................................................................................................................................................................................................................................................................................................................................................................................hp...tp..p.....tt...............t.t.....t......tt...h.......s...t....p....t...s.t..t......ts.h...ssph.......t....h....h........t...s.-..ps+.E.pL...Ipsaa.t+l.-Lhpphphu-SKshpaht.EscsLtp+.Lthu.-c...p+cs....hp-c......hp.ssp...........slppLp-ELpTT+psYEcQLShhS-HLsohN-pLsppp-pIpth+......................................................................	1	28	37	65
+10045	PF10213	MRP-S28		Mitochondrial ribosomal subunit protein 	Wood V, Coggill P	anon	Wood V	Family	This is a conserved region of approx. 125 residues of one of the proteins that makes up the small subunit of the mitochondrial ribosome. In Saccharomyces cerevisiae the protein is MRP-S24 whereas in humans it is MRP-S28. The human mitochondrial ribosome has 29 distinct proteins in the small subunit and these have homologues in, for example, Drosophila melanogaster, Caenorhabditis elegans, and in the genomes of several fungi [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.57	0.71	-4.05	21	297	2012-10-03 10:08:23	2007-08-06 14:08:43	4	2	268	0	222	400	31	121.40	28	36.00	CHANGED	pa..p.ss..ppPlpacaooYhu-t....cPt.sRKVVlplpsssL...sL..sc+pp+KhhhLAGsRYssc........TD........ll+hSo-+aspttQNt+YLsslLptLlcEupc..s-sapDlPlDsRHpph+................pFPccWt	.........................................p.slphphssYhupt...........cPt.sR+Vslp.lplpcL........sL..scctpcK.hh.c.L..s........G........sRYs.p.......................................oD............................llphss-+asp........ppQNtcYhhpllssLhpEutc....s....-sa..pc..h-.hchp...h................................................................................	0	80	122	182
+10046	PF10214	Rrn6		RNA polymerase I-specific transcription-initiation factor	Wood V, Coggill P	anon	Wood V	Family	RNA polymerase I-specific transcription-initiation factor Rrn6 and Rrn7 represent components of a multisubunit transcription factor essential for the initiation of rDNA transcription by Pol I [1]. These proteins are found in fungi.	27.70	27.70	28.30	27.70	22.60	27.60	hmmbuild  -o /dev/null HMM SEED	765	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-13.15	0.70	-6.44	19	144	2009-01-15 18:05:59	2007-08-06 14:14:48	4	7	116	0	108	148	0	591.40	16	77.63	CHANGED	hDPphusLhsluphhshps.css.scshslhshsSGEsussLslphlpccthphpp.......hthshhhpppsstas.s......husPI+QIpau...cshcppsshlulpp.sphhlhps.htt.............h...ppppuplsss.Lhplptsph.ushsauDVsFNPWspp...QhAllDp+GNWolWcl........tpp+pppsshpsspshs.GSl........tDsp-l......ssWtpIpW.............................sschspllVhsRpshh.hchpss.p..h.....Lhpu+shspIhDl++ssp...ppsFlLTopcllWhclss..............shp.hLSW+HahDscDsoL+l..sshts....ppphhhhlaSphs.llhsathuhpsst.hshts..ssallclsspsstpt..........phpsh.hp.t.sc.spssspph...t.phhtlatlsspLslppphhsssspss..spst....ppsshcthtspp.p...t.pp..hp.........................h+hhtc..h.slp..upspps.t-hs....Yuhtlupths..................th.E.hp...t...sphspspshhphLsp.sslssh.pshp-hsshlppl.phhpspphthsshhphhhthhh..............tstspl.slashLhpsW.ss.sp.h........+-plh+p...lstplsLohlts.................................................................................pcpt.t.......splpphhphstpp.....hscsspslLspWc....ttssss.ph........pphhpsshpps....tpsphPsh+.pppssps................pt......................sspsts.ts.p.h......spo.shsp.....s...P..oQhpsst.tsRpttptt......t+KKKRtuGF	..........................................................................................................................................................................hhshh.h.........p......p.h.hhshssGpssp.lpl..ht..pt........................t....ps....h..t...............tsPlpplphs....pt.tt.........p....h...hhlph.tphhlhp......................t...spl.ss.lh.tl..pph.ss..hsDhsF..sPh..p...phAllD.t.G..Wslacl.............h.p...t.t.h......h....t..spl..................c.t.h..........................sth.tl.a...................................sp.pthllhsppph..h.hp..ht..st............................l...tp.t.ph...lhDhtt..t.......p.hh.lL.To.pplhhhth...........................t...hlSh.H...hss.pD.olch..p...h.............tt.hhhhl.S....p...h.h.hh.h..........t...............t.hhlt.s.......................h....h.....................................hthh......th...hh.........t..................................................................................................................................................................................................................................................th.thh...................h.....................................t...hhp.h.p.a....................tt..htt....hh..hhhs.hhh..................................................................................................................................t....................ht.h..t........t......hst.ht.phl.spW........t.pst..t..................................p........tp..h.th+.pttt..t...................................................................................................s......................................s....t.................s..........p......t..t.p...................p+t++h.GF.........................................................................................	0	21	53	90
+10047	PF10215	Ost4		Oligosaccaryltransferase  	Wood V, Coggill P	anon	Wood V	Family	Ost4 is a very short, approximately 30 residues, enzyme found from fungi to vertebrates. It is a member of the ER oligosaccaryltansferase complex, EC 2.4.1.119, that catalyses the asparagine-linked glycosylation of proteins. It appears to be an integral membrane protein that mediates the en bloc transfer of a preassembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum (RER).	21.00	21.00	21.20	21.00	19.80	20.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.34	0.72	-4.46	12	156	2009-01-15 18:05:59	2007-08-06 14:22:28	4	2	139	2	105	156	1	34.50	44	50.21	CHANGED	MIoDspLshlA.sLGhshhlLIVlYHalsssspct	...MIoDspLshhAshLGsshhlLlVlYHalpsNspp.....	0	28	56	83
+10048	PF10216	ChpXY		CO2 hydration protein (ChpXY)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This small family of proteins includes paralogues ChpX and ChpY in Synechococcus sp. PCC7942 and other cyanobacteria, associated with distinct NAD(P)H dehydrogenase complexes. These proteins collectively enable light-dependent CO2 hydration and CO2 uptake; loss of both blocks growth at low CO2 concentrations.	25.00	25.00	125.40	125.20	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.02	0.70	-5.58	18	117	2009-01-15 18:05:59	2007-08-06 14:46:53	4	1	69	0	41	129	44	363.50	58	91.73	CHANGED	lIpRLpuGtALLsDoP-NllEVVGlLKSYGlVLDAYS+NLlYIAEcQFLshFPFFKYF.....................................NGc..hohsKLl+HahHDRINaEYAEYCMKAMhWH....GsGGLDsYLDSsEFpppAc+AIpA+h+pNPlhhsLppLFP-FL.EhlRphuYYouLGQFWRVMSDlFlsLSDRYDpGEIpSIsDVVsHItsGLVAsAucPITYpVpIcG-sY-llPtpAGLTFLhDsAVPYVEAVFFRGoPFhGTVSYNAQApQIPs-QucFpYGALYADPLPlGGAGIPPTLLMQDMhHaLPcYLp-aYcppsRGEcDl+VpIChSFQKSMFCVToAAIpGLtP...aPLDossPpcQtANRAYh-uWhsRlhs	..hIcRLEuGsuLLsDoP-NLhpllGILKuYuVllDtY.+NLlYIAEppFLs.FPFFKYF.....................................pGc..hphsKLh+HLhHDRINaEaAEYCM+AMhWH.....GsGthDsYLDosEFptsuc+sIpA+a+tNPl...hhsLp+LFP-ah.EQlRphuYYSsLG.FWcVMuslFh-LSDhYDpGclpslP-shpalhsGLhAsAu+PIhapVpItGEsY-IlPKStGhTaLh-sAlPYVEAVFaRusPFhGThSYNAQApQlPsDQp-FpYGsLYADPhPlGuAGIPPTLLMQDMhHaLP-YLp-aYpppsRGE-DlhVQIshoFQKSMFCVToAsI.puLtP...YPLDsssPcctpANRsahEuWhsRFh.p.	0	8	30	39
+10049	PF10217	DUF2039		Uncharacterized conserved protein (DUF2039)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3241)	Family	This entry is a region of approximately 100 residues containing three pairs of cysteine residues. The region is conserved from plants to humans but its function is unknown.	22.80	22.80	22.90	37.10	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-10.69	0.72	-3.97	16	147	2009-01-15 18:05:59	2007-08-06 15:03:23	4	4	120	0	92	144	3	91.10	46	43.81	CHANGED	sQKHQN+ssFcsshapp.s.....ppc+lps...hthssl.CpRCp-hIcWKl+YsKYKsls..psp+CsKCpp+oV+cAYHplCcsCupchclCAKCt+ssp	...s.QKHQNp.huFKsshac+.s......pp.c+lss...hhhsGV.Cp.RCK-l...........lEW+lKYsKYKPLo..pP+KCs+Ctp+oV+cAYHhlCcsCApch.clCAKCsKp..s.........................	0	36	49	71
+10050	PF10218	DUF2054		Uncharacterized conserved protein (DUF2054)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3136)	Family	This entry contains 14 conserved cysteines, three of which are CC-dimers. The region is of approximately 200 residues in length but its function is unknown.	20.80	20.80	21.40	21.40	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.39	0.71	-4.31	9	153	2009-01-15 18:05:59	2007-08-06 15:05:51	4	5	112	0	107	132	3	121.10	44	50.44	CHANGED	psps.s.sspCRsSlQG+pLlsD-cGaVCpphsl.LhsGCCs.......h...ssphasCcsC.hsspCCssYEYCVSCCLpPsppsLLEcVL.pusssp.tlhuss.pDtFEhCls+CRTsSpSV.HENcYRs.ctKHCa	.....................ss....t.ttpCRNolQG+.tLlsD-h...GaVCpRpsl..hssGCCs........................hphssscpa..sC.cuC................hs.stCCssYEaCVSCC.LpPs+...ph...lLE..c.hL...........csss.uhp..slhh.ss..pDpFELClu+CRTSS.....pSVpHENsY+ss.tKaCY.............................................................................	0	38	57	82
+10052	PF10220	DUF2146		Uncharacterized conserved protein (DUF2146)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3692)	Family	This is a family of proteins conserved from plants to humans. In Dictyostelium it is annotated as Mss11p but this could not be confirmed. Mss11p is required for the activation of pseudo-hyphal and invasive growth by Ste12p in yeast.	17.70	17.70	17.90	17.70	17.60	17.60	hmmbuild  -o /dev/null HMM SEED	895	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.71	0.70	-6.56	7	293	2009-09-11 14:24:08	2007-08-06 15:07:12	4	6	126	0	207	273	0	348.80	18	75.81	CHANGED	pp.hhphDsplhVVGllGKos........ssphNphlchslhsstspts-....csplpsaapp-splLaLhhsus.Dstslh..hscslpss....s..phh-ahpt.cspasRhLLahhpVCHhlVlVEsopsFDhoahplF+tlchlR...cKhlhph.....L.phl+ssslup.hppcsRhCsPRlLFhFptsss..............sKPcp+-.hcpLEpslE-pIhclLRpppllTNsSusuLhslPpsptFVah.ssc.hcpDslhc.l-hLhtthcps......p..-p-p...lttstshpths.s.t.hpF...ptphpstppch-polhphlhpHVp.sL.ctGh--uss..+pttpopF.l.s.pcWh-hhppLaplhl....pNspcP..s.chus..hK..s.hcsh-t.lch-pKF.tphCpcuL.huh.tYpp.hP.pYssshHcpphspAhpha.cpuRGsp.pthh.pLpp.CpphWpSutptCE..ShhupsCshthH.s.t..p............HsuushhlSoCsCGRpQshRp-Pasl+pANa-FYph.s.pC..CttL.+hpFPlapPso...sDhtsAch.......spshpsh.p.tptpcp.s-ttsp.ch.pshp..hpsspp.......S.s.ssslshph.......pssctstppsps.tpssspp...............t..tpppt+-......tt.tthth.spos-aL.GhspssSshGLLPhFPSWtLssLGsSSlYsHssGLpp..QsuFlsGusaLhPWDV.lR..............hchpsWsAshpplpsc+tu..ppu+pcc+sDhhplKlFVGhEYECuRGHRFhhs.uPDpll+s.Gsslh+-Sus+.....VlpsDMPlYhPCsC..Rs..sphAQLhRlHVVTPKAPVplhl-PKVpl..pph....saspG.......pP..............lcLspSuYWILRLPaVYpG-pGshhsPpEhss..shslhtGhLhsshh	..............................................................................t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	74	98	149
+10053	PF10221	DUF2151		Cell cycle and development regulator	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3711)	Family	This is a set of proteins conserved from worms to humans. The proteins are a PAN GU kinase substrate, Mat89Bb, essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.	17.50	17.50	22.80	24.40	17.10	17.40	hmmbuild  -o /dev/null HMM SEED	695	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.20	0.70	-13.23	0.70	-6.35	6	167	2009-01-15 18:05:59	2007-08-06 15:07:27	4	5	88	0	104	154	0	447.20	40	95.15	CHANGED	M.pcspKTVFVLDHssYFuEuscphl-hDhlcus+sp......hs.luKSLWTCAVEuShEYCRIlaDlaPttKL.lRFlVSDotu+hLNo.WssssQshp-LhsAlshVGsP.sRtsPpssDhSllHGLptAIEALAc.T-.Q+E................Scsstlhc-hp......tltNcGRlIClTsA+oDscMcpLEDplspllhppNtlAAu.Sc+hh.sIspC+LVIlNhYPsG--ohVosRsLpElS..PlLpsEVHSsKAuc.lusKLspLllsHFDLASTTVTsIPMK........EEQ+AsoSANYDVELhHu+cAHs..lhpGsshhsssShK....cGusYETVTLKWCTPRtssSs-hpYCsuAhhlTPVDVsSRPSSCLTNFLLsGRSVLLEpP+KS......GuKllSHhLSA+GGEIFIHsLshsRSp.......L--PPSIu-GsGGRVsD.YRls-hGchM+ppRLhPlscp...sDslsEt.h-........ch+ppLpRhoRYaPhhhupTsIF.N.ch..tl.PLlsLIsKppLoEpDlhpCppsIasLhpMcp+p-sLshsss...GsRlKs.Kc.-EQYRlhasELEpllppasusS.+HKplhcslhssRutssptE.....-+ccuGcKh.sKtshhtK.......sstuuco-chpss.DpEc--..cs....................shsDSPsSPch.p......Kpspssl--.....................................................pththtscGshSLLslhsshlEpupSpKRpEFsGRl.sshGNhAcLYscLuEKpts	..................................................................................................h.hslho..h-s.hEhpRlh.Dlas.t...p..lphhhsD...hhlss.W.....sh........t..p..lht.h..........hu.P..........t.t.....s.h.tGL..Alp.......sLs..o..Q.t................................................................................................NpGpllhh..........T...........php....p..ptph..l.t.h.p.l.p.N...................t.h..lp.hphhhl.hhs......t.........p.t.........t.s....h...lhp.................h..tl..Lh..papLuSTolosIPMK........E-pp..ss.t.SsNYDVplhH.ttsH.......h......t................p............................................s.....pshtlpWsTs......t.....................h.....s..u.h.hoss.stSRPS.CLhpFlhs...G+.sVhLp...p................stchhoHhL.sps......ucIFlHsLs.spsh.......h--sP..sI...p-...ssus+V....sD..YRhsph.t.hhp....hh........................................................................p.sp.hP.h.t.shhh.............l..h.pllhKpphspp-..pCpphlhpLhthttct-.Lshsph...stt...h.c..........pp.c-QYRhhatELpthlph..s.o.tHpplhpsh.thpsh..............................................................................................................................................................................................................................plht.h........t..t..............................h.........................................................................................................................................	0	38	45	79
+10054	PF10222	DUF2152		Uncharacterized conserved protein (DUF2152)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3778)	Family	This is a family of proteins conserved from worms to humans. Its function is unknown.	21.30	21.30	21.40	22.00	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	604	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-13.19	0.70	-6.30	6	150	2009-01-15 18:05:59	2007-08-06 15:07:47	4	4	108	0	86	149	0	440.40	38	91.23	CHANGED	RLKsh....sGhLSSpasRRLLslLhllVlhlaYlhus.hRhs.......Fsuus.s+s.sutChcsclp.Wpt.t-ch-sslps......PtE.p.h..Pal.GNGaluLDlsus.pLaVp.puR...shhh.ssFpPhlslc.tGstsEpcuosl.a+pGll+plRCh........................s.sp-ChhVpppaaAHRoRPsVaVQcIQIoNPpcpllsl-Lss.ph.sh.cthooolchhps...t.....ph.lhoGhl.sVs....sthlhlVslsspchss+LpVs.+sshc.phhhslasScPls.....spht..hph.pppApctMhclhp............hshtshcp-HhclWusLahoGhphusuKst+T.sGssINsThYhhlSpsRAPhl-...sshoppc+-slEpsLsYu-tCasuHuThp.AENLW.pchSslppLhpLhshWhLTLQKRGC+sLlpAGApGllQAMVLSFGGhpFo-sHLphphDP+sLHpsYshRGlp.YsN....spINlulllDpDsKPaLaVulcpp-p..plYAC-AGCLDEPVpLTss.+sH.FPVhVTpPlTsLLYIooDhpHLpDLRHsLHlKEll...AHEEHhhpha+......GLPhLFWhSVsulIslFHLFLhKLIasEY.......CsPusKshaRs+	...................................................................................................................................................................................................................................h.uNGhhh...........h.....................l...h.......t..............h...s.h...h......t.............t.h...h.hh..pG..hhhhpCh.............................t.shhlp.phhAHRshsplhlQplplsNs.h.p.....thph......t............p.h..t.ps..h.h.t..............ph.l.sth.......................t..h..h...hslst.phstplplt.+sphp..h..sl.h.St.sht.........p........p.hp.p.....shpthhchhp.............s.tphhp-H..thWtp.La.sGhphp......p..ps.p.s...su.plNhT.hYhhLSps..u.h.hp.........thstp.c.+p.....phcpsLsYt-tCasGHsThc.A-NLW.tchoohtplhpLsshWhLTLpKpGC+sLlt.....sGA.GhhQuMVLSFGuLpFoppHLpaphDPc.sLHpsath+sIp.Ypp....shlNluVlhct-..s.KshLpVulc..ptp...plYAC-AGCLs-PVpLTpt.psp.FPVhlTpPlTslLYI.osDhpHLp-LRHslHlKtll...AH-cHhht.........GLPhLFWhSlsuLIslFHLFLhKLIhpE.Y.......ht..............................................	0	33	40	64
+10055	PF10223	DUF2181		Uncharacterized conserved protein (DUF2181)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3748)	Family	This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.	25.00	25.00	30.20	28.50	18.80	20.60	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.62	0.70	-5.02	10	192	2009-01-15 18:05:59	2007-08-06 15:07:58	4	2	94	0	120	194	0	225.50	35	76.71	CHANGED	DuhplTWhHAsNS+ptLs-sL..s..SslphIEADVslpthpp..usEpplPIMAHPPAhsSDlTLcEWLcpVl.........sppKGIKLDFKSlpAVcsSlDlLc.sltct....lphPVWINADILsGPsss..ossVDsopFhstlpphhPpsTLSlGWTTtassshssssYTpshVcpMhcllpt.....LsQslTFPVRAulstsShspLpWL...LspopRYSLTlWouAsDsl.sV-DLlhlRcshuhcRlYYDl.EsltsQ	....................................shh.lhW.hHAsNppt.httuL.....p.........ush.h.h....lEADVhlt..tt...sscps..............hP..IMA.H.P..P....th..s.SD...TLppaLp.plh....................ss..pK..G.I..KLDFKo.lpAlpPSlslLp..phppp.....................lptPVWlNADIltGPsss....ss.VsuppFLstVpp....haP........csTlS..GWT.T..a.h.p......h................sts....Yo.phl.ccMhplspt.......LsQsVTFPVRAu.hl.t..p..S.h.s.p.l.thL.........Lpp..S.....s..R...h....oLTlW.p..u..t...s..D..h...sl..psLlhltcshshpplaYDl.cs......................................................	0	33	46	76
+10056	PF10224	DUF2205		Predicted coiled-coil protein (DUF2205)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3650)	Family	This entry represent a highly conserved 100 residue region which is likely to be a coiled-coil structure. The exact function is unknown.	26.70	26.70	26.90	27.20	26.20	26.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.62	0.72	-4.41	8	221	2009-01-15 18:05:59	2007-08-06 15:08:21	4	2	190	0	155	220	0	77.70	41	58.26	CHANGED	huschsut-lE.th-pEt+p+LIpQlLpLQsoLc-LupRV-uVKEEN.KLcSENphLupYIENL...MosSsVhpSoosp..tpK	....................phps.-hc.phphEt...+pcLl.....p.....QshpLQsoLc..s..LupRlDuVKEEs.KLcoENphLtpYIpNL....MS.s..SsVhpoos......................	0	46	76	122
+10057	PF10225	DUF2215		Uncharacterized conserved protein (DUF2215)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3817)	Family	This entry is the central 200 residues of a family of proteins conserved from worms to humans. The function is unknown.	28.70	28.70	28.70	28.70	28.40	28.60	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.55	0.70	-4.93	16	259	2009-09-10 22:40:12	2007-08-06 15:09:00	4	6	118	0	156	265	0	218.00	28	54.65	CHANGED	aslslppt.hphaRlhhhlhGllLhhhushLSpshsFYYsoGhulGllsslLlllahhh+lhP..++ohhhhhlhGua.uhuhYhlphhhpNlp.Ilhpa..........thaVlsalhhsGh......lphhlshp.ssshstpstphlpWslphluhshlhpSs..spluhuhllhshhh......thhhhslp.........hhhthtphh+...............tph...ssth+.LspcEhcpQGphcopcuLppLR...........passSPptssh.....pshu+lpsPpphuchhpuo.sHloss	.........................................pl.l.pp.hshhhhhhhhhGlhLhhh..u..phL..S.c.s...hFYYssGhslGl....h.hslllllahht+hhP....++s...h...hh.....l.lhG..uh.sh........uhYhlp.l.....hpslp.lhhpa..................................h.allsallhsGh.................lshhlshh.hss.........s..pohpl............lpWslplluhshhh.u.s...thuhshl.lh...hhh...........th..hshp.........................hh..hhhhhhp.......................................................................hh....s...+hLop-EYp..psthpTtpuLppL+...........phspp.Ppht.W......hhsplp..sP...c.hs.p.h.ut..Hh............................................................................................................................	0	42	66	108
+10058	PF10226	DUF2216		Uncharacterized conserved proteins (DUF2216)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3819)	Family	This is the conserved N-terminal half of a proteins which are found from worms to humans. some annotation suggests it might be PKR, the Hepatitis delta antigen-interacting protein A, but this could not be confirmed.	22.40	22.40	22.40	24.40	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.45	0.71	-4.80	11	174	2009-01-15 18:05:59	2007-08-06 15:09:23	4	2	80	0	104	154	0	177.10	55	45.64	CHANGED	usu--LScloDEELLpWSKEELVRRLRRsEAEKhulll-HGNLh+EVNRpLQhHLsEIRuLK-VNQKLQEDNQELRDLCCFLDDDRQKGK+lSREWQRhGRaoAulMRKEVulYLQKL+ELEt+QE-llRENLELKElC.......LhLDEE+.............sutusuGsRsSlDSQsuhs..s..u....ssRDVGDGSSTSSsGSsuSPDp	..............................s......thsD-EhhthuKE-Ll+pLR+tEu-+hshhlp+upLhpEVNRpLQhHLsEIRuLK-lNQ+LQ.......-DNQELRDLCCFLDD..DRQKG++.l.uREWQRhGRYoAuVM+cEVuhYhQKL+ELEs+Q..EEll+ENhELKELC.......lhLDEE+......................ss.usu.G.up.sShDuptsh...s.....st......hhRDlGDGSStSSsGSssSPDp..........................................................	0	20	31	63
+10060	PF10228	DUF2228		Uncharacterised conserved protein (DUF2228)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3952)	Family	This is a family of conserved proteins of approximately 700 residues found from worms to humans.	25.00	25.00	27.20	29.90	20.50	22.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.53	0.70	-4.83	9	139	2009-01-15 18:05:59	2007-08-06 15:10:22	4	6	101	0	86	138	0	213.50	42	61.87	CHANGED	GLpLVGPF-lLuGcacssphtps.sahhHWRaaYDPPEFQTllhsspsothHhGYaRDpPsshss.hluhN-sKpusphshlG-NlFsAllhFLp+ph+pps.pKtphuAhcKl.t.LpctApphshtLpppschhKpRcKclVsKshHtuGlV..VPhs.Ksc.......lGYR.LscoD..AsLK+ll+slsc...spscpccpcshs.lQtlhThlphANDECDaGhGLELGhDLFChGs+thHclht.LLshAYshLpRspFspI	....................sLpLVGPa-lLuG+a+htpt.....tps..sa..hHWRFaY..DPPEFQ..........Tlll.....s.spp.....sthHhGYa.R..DsPschPs.hluhN-.u..p..pss.h...Gs.NlFsAlhhal.cchp....t.hs.p..p.thshhppl...........tt...Lpchspp..shpLppps.hh..........h+.pRp+.+.lVs+TFHtsGlV..VPhD.+sp..........lGYRpLsto..D..spL++lhctlhc....utscpp+.psh.........s.lQ.EhhohsphAsDECDaGh..GLELGhDLFsh...Gp..c....h........hpphhtpLLshAYpLLpRs.FhpI....................	0	34	40	65
+10061	PF10229	DUF2246		Uncharacterized conserved protein (DUF2246)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3994)	Family	This is a family of proteins conserved from worms to humans of approximately 300 residues. The function is unknown.	21.80	21.80	21.80	24.40	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.85	0.70	-5.11	9	180	2009-01-15 18:05:59	2007-08-06 15:10:35	4	5	127	0	98	165	1	216.90	32	67.15	CHANGED	tLhp+sstsRuhshsssuuScpshhshhs.shhs+s.shPc-shGsFGspDpphpLsGslsassclsuhshphcs.h..ph.lP-sls.s.pscppphhhsp.lsE.......lh.pclpps..p..hssuplEsuhppCP-LL++-htplFP....shsssslTVlTlTQ+s......hupthEp-REpLhp+FlpuAKEIC.sLhotGYWADFIDPhSGtsaFushTssTLacTDsRaRpLGF+lEDLGsCpVIpHphhGTphFVGTIFTsAPscSslht+Lhu	.................................................................................s.................................................t...t.ht....p..h.sp....s....t.............................t..h........t....th......t.lt......................ht...............ht.p..splEhslpsC..P.cLL+c..chcplF..P...................ph...........ss...splhllsl..oQ+o.....p.s.hs..hspp.sEtE+EhLhc..cFlpsAp-lChsLp........spGYWADFIDPpSGhsahu.s.h.s.ss.slh.-sDp...........p.a..p.p..L.......Gapl..ps.hGsC+VIpHshWG.o........psas...........GolFTsAssp...h.pl..s................	0	36	50	75
+10062	PF10230	DUF2305		Uncharacterised conserved protein (DUF2305)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3975)	Family	This family of proteins is conserved from plants to humans. The function is unknown.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-12.07	0.70	-4.98	27	346	2012-10-03 11:45:05	2007-08-06 15:11:11	4	7	258	0	233	951	208	239.00	24	77.85	CHANGED	schlllhIPGNPGLhsFYppFlptLtpph..............sspatlhsloauGa.shpsps................pchasLpsQlcHphshlcphls............hch+lhllGHSlGuYluhcllc+hs.................phplhtshhLhPTltchucSssGphhohh....hht.hhhhhhssh.hhhhhthLPttltphLl.phhhsss.................sh.ssshh....hhs.pslppslaMAtpEMppltp.c.....-phhpt....................+lhFaaupsDpWss.phhc-lhcths..p.........ss.....hpls-.cslsHAFs	...................................................................................s...llhhIs......GNPGlht.aYt.......FhptLhp..h.........................................................t.ph.lhshuhhGa.s..spp....................................p..tcha..s..L..p...tQl..c..a...phph..lpph..l...................................tphpllllGHSlGuYlshclhcch..........................................thplh.tshhL.....a...........P.......T..l..p.......c.hs..p.S..ss.Gph....hs.h.............ht.h.h..hhh.hhshh...........hhh......th.....lPt..hh...hp....hll..phhht.................................th.hshh......lhp..ps..ltps.l.h....hu.tpE......ht.p...ltp.p........pphht.....................h.......................................plhhha..up..pDtWss.phhcclhp.ths...............p......................h.lsp..psh.HuFs.....................................................................................................................................................	0	79	124	193
+10063	PF10231	DUF2315		Uncharacterised conserved protein (DUF2315)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4094)	Family	This is a family of small conserved proteins found from worms to humans. The function is not known.	21.40	21.40	21.60	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.45	0.71	-4.26	6	120	2009-01-15 18:05:59	2007-08-06 15:11:38	4	6	88	0	72	116	0	115.80	41	54.95	CHANGED	ppDaIGPPDs.SNLRPlhh+hs-NETcLE++LRthRpEsppWNs-FWucaNhpFpcEKE-Flcpc.......L+cEuGpppclsA--MucFYKsFLDKNaptHhhYNhcWY++NhsllhLuhtVsLpRlapth	........................DhlGPPDthSNLRPlhhhh..scsE.o..L....E....p.............cLRthRpEsppWNppFWsppNhpFpcEK--Flppp..........................l+ppsG..ptpl..sA-.-MucFYKpFLs+NappHhhYNhpWYc+NhslhhhhhtVtlpphht.h................	0	29	35	54
+10064	PF10232	Med8	Arc32; 	Mediator of RNA polymerase II transcription complex subunit 8	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3583)	Family	Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex [1]. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20 [3].	25.00	25.00	25.10	25.70	24.20	23.20	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.45	0.70	-4.84	7	254	2009-01-15 18:05:59	2007-08-06 15:45:29	4	6	216	8	171	240	1	224.60	26	88.67	CHANGED	Mpp............spcph..........tsL-ulhpRLspLppSLsphltpLp......pchch.sWsoh.spFsll.upLsolophLtppp.shLcspslhPh.hhPs+scp..............sllsshLRTKssPcVE-hhttsctthts.tssputpp.................lhp.s+hhpph.............hshlochR-.Eh-..upppht.ppshp.tcsphllttht.upshp...................................t.p...sh....t.t...........ssslhp........hpou....s.pR	..................................................................p.h.............tsL-slhpRlspLppSLtshhtplp...................pp.th.sW.................sol.sphsll...sspLpolschL.........p.......c.......p....p.....sh........hc.shllhPhsh.Ps+sc-................................sl.lsshLRTK.-P-....VE-h.pphpt...t.u.s.ph.ss.c...s..utp.p..................................................ltphsch..hpph...................................hphlsp..tc.....-h.....-..tp...st.t.t......t....pp.p.......p.....p..........t-..........tphls.tt.h.t.utsht..................................................................................................................................................................................................	0	48	83	135
+10065	PF10233	Cg6151-P		Uncharacterized conserved protein CG6151-P	KOGs, Finn RD, Coggill PC, Bateman A	anon	KOGs (KOG4085)	Domain	This is a family of small, less than 200 residue long, proteins which are named as CG6151-P proteins that are conserved from fungi to humans. The function is unknown.  The fungal members have a characteristic ICP sequence motif. Some members are annotated as putative clathrin-coated vesicle protein but this could not be defined.	26.40	26.40	26.80	29.90	25.20	26.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.49	0.71	-4.10	25	228	2009-01-15 18:05:59	2007-08-06 15:52:44	4	5	197	0	155	227	0	109.10	35	61.65	CHANGED	hGllshlLChALGlANlFph...ssl.IlFullsllpGhlllFlElPhLL+ICPhospFssFl++hssNahRAuhYslMAllpalSlshtsTSLlusAlhLsloulhYuLAult+Q	...................................hGllshlhChhhG....lhN...lhsl.....ssl..Ishullpl..hsuhlllhlEsPhhhph...sshus.shsphlc+h.ssa.RAshYssMAll..lsls..h..s..hoSLlus....Alhhs.oulhYuLuult+p......................	0	38	68	120
+10066	PF10234	Cluap1		Clusterin-associated protein-1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3647)	Family	This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell [1].	24.20	24.20	24.20	34.00	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.61	0.70	-5.19	15	186	2009-01-15 18:05:59	2007-08-06 15:53:50	4	6	127	0	126	186	4	229.40	42	63.34	CHANGED	RhLGYPRlISM-sFRsP.....NFtLVA-lLhWLlp.........................RYEPss-Isssl-oEp-RVhFlKulspFhsTKu+IKLNs+KLYtADuaAV+ELLKlTslLhsAhpos.....stp-E-s.....ottphslusKlsDLKtsRpLuS-lTs+GuuLaDLLsKEl.pl+-sRppslu..........RshElsplE+sl+puIpsspsclpphps.LsslpuDcssLEuKIc+KKpELERspKRLpuLpsVRPAaM-EYE+lEpELpclYppYlc+aRNLsaLEpQL-shs+tEptph-	..............................................RhLGYP.RhlSh-sFRs.P.......NFtLVu-lLhWLlp.........................+a-Ppspl.s..s.l-oEpcRVhFl+shsph...hh.....sKu+IKLNsKKLYtADGaAVpELLKlsslLhpAhpsp.....................................t.t-pp..........shhph.s.lss+.ht..-lKt...sRpLuS.-lTppGAsLa-LLucEh.ph+p..Rppslu..................+shElsp.hE+sh+..slpph.tplpphpp.lsslts-EssL-sKIc+++.ELERspKRLpsLp............slR..PAaM-EYE+hEpELpp.YphYlp+aRNLsaLEppL-phpchEpth....................................	0	54	68	100
+10067	PF10235	Cript		Microtubule-associated protein CRIPT	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3476)	Family	The CRIPT protein is a cytoskeletal protein involved in microtubule production. The C-terminal domain is essential for binding to the PDZ3 domain of the SAP90 protein, one of a super-family of PDZ-containing proteins that play an important role in coupling the membrane ion channels with their signalling partners.  SAP90 is concentrated in the post synaptic density of glutamatergic neurons [1].	23.70	23.70	24.20	25.80	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.70	0.72	-3.63	17	204	2009-01-15 18:05:59	2007-08-06 16:22:19	4	4	187	0	153	182	0	90.10	43	72.48	CHANGED	oclsTPssh+cus............................+ssss.Gsptl.scNKLLSpttp...sPYush..ssC..chCKsplcQ.Gp+YCppCAYpKs..hCAMCGKpl..sspsh+poss	.................sclhTPDsaKcus..............................pso.spu.G.uR+l.sENKhLosppp..............hsPYu...........p............h....sp..............C..+lCKspVHQ.Gu+YCQsC.AY+KG..lCAMCGKpl.hsTKsY+pos..........	0	54	78	119
+10068	PF10236	DAP3		Mitochondrial ribosomal death-associated protein 3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3928)	Family	This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis [1]. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix [2] and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).	23.10	23.10	23.10	23.20	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.90	0.70	-5.49	29	361	2012-10-05 12:31:09	2007-08-06 16:22:52	4	8	283	0	251	385	6	276.70	23	66.47	CHANGED	slVRctol-l...hctlppt.......ptsppsh+hllsGppGoGKSlhLsQshsaAhpp...sWlVlplPpspphlpusspat.ss..p.thasQPhhstphLpchhpsNp.phLpp..lp..locca.hh............tpsstsspoLh-LlphGhpcsptuh.ss...hpAlhpELpspus.............hPllhslDshsthhps..opY+ssch.......p.Icsc-Lslsphhhshlt.....spsshssGssl..LssTusspssp..sh.hsLtttts...................-Pah.....c..h.t.h.................shpVs.shoccEscshhcYatcsshlpcp............sscphspEchhhsusGNstEL.+h	..........................................hlRp..shcl........hp.hppt......................p.tt.sh+..h.ll.....hGtpGsGKohhLs.psh.p.auhpp....sWlllalPp.u.p.th.sp...s...spp.hh.ss...........p..........th.........asQPh.stphLp.........phhpsNc...phLpp...lp......lppc.a.hs................................................................tpthtts.psLh-llp....Gh.p.....p.....sp.....h..us.....ss....hthlhpELptpsp.................h.lLlslD...shsthht....oph+p.....ph.......................p.ltsp-Lslsphhh.ch............sppsh.sGshl....lstou.t.t.p..........h....s..lhttts.......................................ssah.........................................ht.ls.shs..pEhpshhpYahppthlpp....................................pp.h.cphhh.ustss..h........................................................................................	0	96	144	210
+10069	PF10237	N6-adenineMlase	DPPF;	Probable N6-adenine methyltransferase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3350)	Family	This is a protein of approximately 200 residues which is conserved from plants to humans [1].  It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteristic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes [2].	23.20	23.20	23.50	23.20	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.21	0.71	-4.57	31	349	2012-10-10 17:06:42	2007-08-06 16:25:33	4	12	224	0	245	348	10	157.00	29	54.77	CHANGED	QLSQFWYu--TAptLu...ctllpssscs.....stIAhlSAPSlYttl+p.............phsspplhLhEaDcRFsl.hutc..Fs.......aYDYNpPhclPtpl.ct..phDhllsDPPF......LsEEC.pKsuhTl+hLh+s................ph+llhsTGctMpchs.phl....sschssFhPcHppsLuNEFRCYuNF-s	...........................................................hSQFWYu-cTsphLs....ct.lhp.....ss..p.s...................splAslSsPolattl+p............................tts.ph..pshLhEaDpRFsh..a.st-..Fs..........FYDas.p........P..h........c..l..s..pp......h....pp....ph-...hllsDPPF......Lsc-ChpK...h...up...ol.chLhp.......................................cll....h....sTuth.tth..htphh............shp.s.ta.Ppatp..Ls.pahhassat.........................................................	0	78	127	198
+10070	PF10238	Eapp_C		E2F-associated phosphoprotein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3395)	Family	This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis [1].	25.00	25.00	37.10	26.20	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.08	0.71	-4.27	15	144	2009-01-15 18:05:59	2007-08-06 16:52:27	4	2	111	0	99	138	2	130.80	42	54.62	CHANGED	LY.DsctD-c-ccWVccph+tt....................tsssoDAlLsCPuChTslChcCQRHEpYpsQYRAhFshNCplsc-pll...p+phsspcp+csppcscpstptstt..............................................................................ssEhY+sVpCspCuTcVAVaD.c--lYHFFNVLsS	..............................................hY.DPchDscDptWVstpR+sh....................................................................sSDAV.LsCPuChTTLClDCQRHEpYpsQYRAMFVhN...Cpls.c.-clL..h.tt...ppc.p...pp.c..t...tpp.ppt..t.t.....t....................................................................................ttptp-hY+PVhCspCuTcVAVhD.cDEVaHFFNVlsS..............	0	43	59	76
+10071	PF10239	DUF2465	FAM98AB; 	Protein of unknown function (DUF2465)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3973)	Family	FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.	25.00	25.00	25.90	25.40	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.01	0.70	-5.22	13	277	2009-01-15 18:05:59	2007-08-06 16:52:43	4	9	106	0	148	226	3	270.10	39	72.72	CHANGED	lLDsLcsLGY.cGPlh--s...sLppAspuGhuSs-apsLstWLsscL+llssl...-Eplo...ss-Dh-o.FpLElSGhL+ELuCPYssLsoG.lssRlpspccpLhLLhaLsoELQAs+llts++sppttpcp.........sosshQtlpslshsLslscs.ssslshhthFspIps+l..pchlpph.........spsplupPLL..KcsLsspQWccLEplspsLpsEY-hRR+MLl+RLDVTVQSFtWS-RAKs+tsphschapstRpsLss....psslslAcLLAARpDl..upl.+TSSushRcpTssuIN+lLh.G+VP.DRGGRssEhtsPs.EMPsWpKRp-GG	...........................................................................................................t.........h.tuhpt.Ght..ss-aptLshaLss...plp..hspl.......-Eplp.........ts.s-...h-..p..F.hElSuhLtEht.............CPatsLhsGclppclhppps..pLhLLhaLhoELpAs+hlphpp..ppt...pt........................................ssphhp.-lpthh.sLuhscs....ssshs.h..thhstlcp.Kl..p-hLs.pl....................sssplucPLL...ptsLsstpW...Ep...lEpl...............s.psLtsEYcsRRphLlKR....LDV..T....lQSFtWSDRAKs.p..s-.plsplapPhRpsLss..........coslolAcLLA.....AR.pDL..uplh+TSSushRcp.T.ssuINKVlh.GpVP.....DRGGRssEhpsP..............MPsWppRptt........................	0	39	53	95
+10072	PF10240	DUF2464	Fam125A; 	Protein of unknown function (DUF2464)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4000)	Family	This is a family of proteins conserved from worms to humans. Members have been annotated as FAM125A proteins, but their function is unknown.	20.70	20.70	21.30	22.80	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.52	0.70	-5.04	12	190	2009-01-15 18:05:59	2007-08-06 16:53:13	4	6	92	1	109	163	0	219.10	34	81.91	CHANGED	pPlTulshlushspsPpsassIspThD.ussAsLh+s...Fsp+sshYLChSps......sh.s.Vlsslplls-KsslPhGas.lscshDocppsh+KKplCl+hhP+soscsAlsDIplsu+sKpsP.sYphlG-IsuhhIahKpus.....P.slPcspsho........................................pshpshslsu.........sspPuPshPht.s.o.......psts.htts.hhpsuslYslSuh-GVPFhlpP+F....ssss.ssps.hthplcolsclcpEYsYsFssE	.................................Ploulsh.sus..tspsPpsas....s.lupTsD.Gs-AsLa.+s....FtpKs.sR.YL....Cho+shs........sh.ssVlsDhplls...K.-.slPhGF.sl..p-ThDopptsh+......K.KRlClKhhP+.suscsA.....lsDIp..lh.u..+........o........Kp..sP..t.Y..phl.G.-lsuhsIWh+hup.............lPpsps.s..........................................................ps.ps..p..ss.........ss.pPu....Psh.s.t.s.s..................................ttts...ttts...h..ptu..sl.hshouh.DGVPFhl...p.+h.......t...t.t.....h.....hplpoht..clpccapYsF.hE................................................................	0	29	39	76
+10073	PF10241	KxDL		Uncharacterized conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3443)	Domain	This is a family of short proteins which are conserved over a region of 80 residues.  There is a characteristic KxDL motif towards the C-terminus.  The function is unknown.	24.00	24.00	24.20	24.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.86	0.72	-4.08	12	243	2009-01-15 18:05:59	2007-08-06 17:10:16	4	9	211	0	171	217	0	85.50	31	44.06	CHANGED	ssRhtshhsstclsshlttQpph.u+Lptppc.LLphpsLupsRLppspscFtpth+hhp-hKcDL-ahh++lculKuKhtppYPpta	.................pphtshlsstcl..sp.hlttQpph....s+hpppsc.Lhph.psluppRLpphpp....cF........tctt+slp-........hK.cDL-hlh++l.........cslKuKltppaPcta.......	0	46	78	132
+10074	PF10242	L_HGMIC_fpl		Lipoma HMGIC fusion partner-like protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4026)	Family	This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans [1] and hypospadias [3], and LHFPL1 is transcribed in six liver tumour cell lines [2].	25.20	25.20	25.40	25.30	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.63	0.71	-4.28	18	458	2012-10-03 00:20:40	2007-08-06 17:10:50	4	5	97	0	283	414	0	165.10	32	78.27	CHANGED	hulLWslholshAhlplluFlpPpWlss.......ssp............sspsuphGlaphCh.......hhp..hthpCsshshsFtslsSus....a.psushFluluhhL.LsslshhuLhshCp.....spola+lCuhhQhluulhlhlGChlYPhGWcSscV+chCG.cuspaplGtColtWAahhAIluhhsuhlLoFluhlLus+	.....................................hGslWs...lholshuhhshlsFhpPhWlhs.......s..............................................tspss.FGlaphC...............................thhs..ht.pC.ts...h..........sFss.IPSss........a.+s.us.hh...luhuhhL.....lss.l.sh....h.u...L....h.hh...Cs..................s.t.ola+..ls..uhhQh.hu..u.......hhlhlG..sh.laP.GW.s...........upcl.+.p....hCG...tpss.tap.l.G.p.C.sltWAahhAlhuhhsuhlLshhshshu.p......................................................................	0	69	96	171
+10075	PF10243	MIP-T3		Microtubule-binding protein MIP-T3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3809)	Family	This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3.  The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved [1].	32.30	32.30	32.80	32.40	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.98	0.70	-6.04	13	257	2009-09-11 16:48:08	2007-08-07 14:41:36	4	16	131	1	160	235	12	349.50	20	82.10	CHANGED	hcGLYTssEhcusslpDK-sKltFLQKhIDllphsoGcsLts+PuKIVAGpEPE+TNELLQtlu+suts.pLspcpAV++l...ttuppps.sshsp.sp-tcscssppcctcccpppcc+ccsc.c.ppppcttp.ppph...c-ppp.pE+c+p.ccKpppsstccpc.sccppp+ppsptcppctp..........................................................t.tpptpp..pppcs+ppstpp.sucsccttpstctcctpsct.s.-ps..t..tp....................................................t.p..hpt....s.p........t............t......t............................................................................................................................s......stssoAR.usPR.Kcpp.....t..sttt.uchhssVlh-shp......s-s--c-phhh.tttt.sp................st...s.....ppt-pcGtL.Vp+ILETpK-h-stsupsp....ttppt.................tsptppshssc-lppLRpplQpLs+SspPLGKlhDaIpEDIDuMppELphW+pEt+pptpthpcEpphT-sAlcPLpspLtpLEppIsDppsKIssl+usILpN-p+Ip+hltsl	.......................................................................................................................................tt.htp+p.tKhtaLpphlthh....t..h.spst+lluG.EsctTN.hLQhhu.sh.......hp.t..thhpth..................t..t.t.........t...tt......tt...t..t.......t.p....p..t.t..tt.ttp.t..p..t............................t...................t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	79	101	139
+10076	PF10244	MRP-L51		Mitochondrial ribosomal subunit	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4045)	Family	MRP-L51 is a family of small proteins from the intact 55 S mitochondrial ribosome [2]. It has otherwise been referred to as bMRP-64 [1]. The exact function of this family is not known.	25.00	25.00	35.40	35.40	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.19	0.72	-3.96	8	96	2009-01-15 18:05:59	2007-08-07 14:52:15	4	2	87	0	65	98	0	92.90	50	57.29	CHANGED	hPc.KshDRWo-KRAhFGVYDNIGILGDF+hHP+-LIhG.PsWLRGa+G....NELQR.hIRK+pMVGsRMhh-D....hHNLpKRI+aL.....Y+RFNRpGKHR	..hP.h+shDpWsEKRAhFG..D.IsI.......LG......sh.chHP.pcllhu.PsWLRGapG....NELQ+.hlRK++Mlus+hasps....h+sLpKRIpYL.....YK+hNR+sKh........	0	17	22	46
+10077	PF10245	MRP-S22		Mitochondrial 28S ribosomal protein S22	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3890)	Family	This is the conserved N-terminus and central portion of the mitochondrial small subunit 28S ribosomal protein S22.  Mammalian mitochondria carry out the synthesis of 13 polypeptides that are essential for oxidative phosphorylation and, hence, for the synthesis of the majority of the ATP used by eukaryotic organisms. The number of proteins produced by prokaryotes is smaller, reflected in the lower number of ribosomal proteins present in them [1].	25.00	25.00	25.00	25.00	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.59	0.70	-4.97	6	129	2009-01-15 18:05:59	2007-08-07 14:52:31	4	3	90	0	79	119	0	209.00	47	67.02	CHANGED	pPlFhcc-VQpLLpshTpL-LD.KVFR+Rss+s.spscaKhMT--QL-cphhpslEpAcphLQMPPVlc.+p-ssc.VlAKDhuLKuh..uTsKaVFTDITaslscpcRpIVVREPDGTLpcAshEpRcRlNQlYFPLpGRplhsPhMFc.-cpLpchL-pscaEFVLDRsCVQFEP.-s-Yp+lotpVY-+lNE.................oppF-hLRSTRHFGPhAFaLAhp+tIDc.LLhDhIp+DhLcsuspLltLhptLH..P	.............................................hFhctcVQplLhphTtlsLp.KsF+.th...t..p.....psspaKhMTptQLccthppshctA+hhLpMPP.Vlp.R...tshsc...VLucDthLcGh..-ouKaVFTDIoaulsc+-RhIVVREP.sGTLRcAoaEERDRhhQlYFP+cGRclhsPhhFp.-.Ep.....Lpphhppscat....lLshshsQFEPDs..s-Yh+lpppsY-clsc.................ptpa-lLRSTRHFGshsaahs.p+pIDs.LLh-.lpc-hlp-AspLlpLhphlH....................	0	31	36	59
+10078	PF10246	MRP-S35		Mitochondrial ribosomal protein MRP-S35	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4078)	Family	This is a family of short mitochondrial ribosomal proteins, less than 200 amino acids long. that are highly conserved from worms to humans. The structure has previously been referred to as MRP-S18 but the current numbering fits the preferred nomenclature from these authors.	24.40	24.40	24.80	29.10	23.30	24.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.12	0.72	-4.10	6	114	2009-09-11 12:55:10	2007-08-07 14:59:26	4	5	84	0	67	106	0	96.20	56	45.93	CHANGED	ppsspSFuSLLRpShhlQLGsscGKlllGKIFHlV--.DLYIDFGhKFHCVCpRPAssGEcY.RGoRVRLRLcDLELooRFLGuopDlTlLEADAsLLGLlpspsp	...............s..sscSFAShLRpSsLhQ.hGs.u.csKlVlG+IFHlVp-....DLYIDFGuKFHCVC+......RPph.sG..c..p.Y.+...Gs+VRLRlhDLELoo+FLGuspDhTlLEADshLLGl.ps..p....................	0	20	25	48
+10079	PF10247	Romo1	Mit_gmP; 	Reactive mitochondrial oxygen species modulator 1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4096)	Family	This is a family of small, approximately 100 amino acid, proteins found from yeasts to humans. The majority of endogenous reactive oxygen species (ROS) in cells are produced by the mitochondrial respiratory chain. An increase or imbalance in ROS alters the intracellular redox homeostasis, triggers DNA damage, and may contribute to cancer development and progression [1]. Members of this family are mitochondrial reactive oxygen species modulator 1 (Romo1) proteins that are responsible for increasing the level of ROS in cells. Increased Romo1 expression can have a number of other effects including: inducing premature senescence of cultured human fibroblasts [2,3] and increased resistance to 5-fluorouracil [4].	24.10	24.10	24.90	25.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.19	0.72	-3.78	19	272	2009-09-11 01:43:06	2007-08-07 14:59:42	4	2	243	0	191	236	1	65.30	47	65.22	CHANGED	sosa-+l....KMGhhMGssVGsshGhlhGsasshptGstspthhtslGphhlsSuuoFGhFMulGollRs	............PSsa-+h....KMGhhMGs..................sVGhshGhlFGsauhh+hG.......hts.ptlhpslGphhhsSu.uTFGhFMuIGosIRs..........................	0	53	101	156
+10080	PF10248	Mlf1IP		Myelodysplasia-myeloid leukemia factor 1-interacting protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4049)	Family	This entry is the conserved central region of a group of proteins that are putative transcriptional repressors [3]. The structure contains a putative 14-3-3 binding motif involved in the subcellular localisation of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila [1]. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.10	0.71	-4.66	9	258	2009-01-15 18:05:59	2007-08-07 15:00:23	4	2	114	0	123	239	1	155.10	36	64.12	CHANGED	MRpMhtuF.u-PFu...hlSloDtph+u.sR.usstt..........ssa....hhuMsuhhhsMhshMpshhtsh-ph.ossssspoFSSSoVhoYSss.GDusPKVYQtTSpTRsAPGGI+ETR+olRDS-SGlE+MuIGHHItDRAHIlcRScN++TGDpEERQ-FINLDEu-AtuFD-EWppcs	.............................................................................................h....tsh......s..s.t.............t.....t..t.............................s........h.shst.hh......s..h.......h..s............M.ph...............tp..h..tph....ss.s..s.s..spoFs..SS.oVhoYSps....sst....PplaQ..s..o.oppR.suPG....G..l..+..ETR+sh+DScoGl.ccMuIGHHItD..RuHllp+ppNp+oGcpEppQ-al.N..lsEs-AtsFDcEWppc..................	0	32	47	83
+10081	PF10249	NDUFB10		NADH-ubiquinone oxidoreductase subunit 10	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4009)	Family	NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.	22.20	22.20	22.20	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.73	0.71	-3.99	8	155	2009-01-15 18:05:59	2007-08-07 15:00:34	4	2	122	0	94	150	0	111.50	40	70.28	CHANGED	DtPVThFR-.lVEp.ps+sKasYYHpcaRRVPslspCtssDhlChaEA-hQaRRDhtVDpEIVplLppRhcsCpQhEupsHh...QsCuK.lcQaccsscsa..+YGDLGAYusARKshMKQKHRMlhER+	.................DhPlThhR-..hl-...spp+h.aYHppaR...RVPslspChpsDhlChaEAc.Qa+RD+hVDpEIlpIlp-RlcsCtp...h...EG.....ssah.......QpCt+.lcQapcsscsa..+Y..t-LGshh.ss+pshhKQKpRhh.ct.......................	0	32	46	70
+10082	PF10250	O-FucT		GDP-fucose protein O-fucosyltransferase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3849)	Family	This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese [1].	26.80	26.80	26.80	26.80	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.21	0.70	-5.34	62	1215	2009-01-15 18:05:59	2007-08-07 15:00:56	4	28	188	6	759	1192	4	302.80	22	67.15	CHANGED	llh..s.G.GhNppRss..hhchlshA+hLNt...........TLVl...............P.hpp..hhWpcss.p.....Fsc...hF-l-p.........hhphl.sslclhchl.............Pphhsth....................................................phhhshphs....hsssphahpp..h..hhtch...........pVltlstssspLssphhshpl...Q+........uLpaspcIpphupphlp+hh................................psssalulHLRhp.Dh..hpsC.h.tht..ptt.htt.p............t.p..ps..hphpspsPhtspts.....shlLpslth...ps.......splYlAosp..........ht...th..psLpshhsphh...+pplsstc-ht.h.s..sphAtlDhhlsspu-hFlssp...ss.hsthlttcRchh..s.h........................ssF	...................................................................................................................................................................h.....s.G..Ghsp.+.t..........hhshlshA+hLNt.......................................................TLVl...........................................P....htt.....ha........p......c.s.....p........................Fpc........hF-h..ct................hh...p....l......t..slpl..c.l..............................P..h.t....................................................................................................................t....hph...t.....hss..ph.hhpp......hhshh.p............................tslt.l.....s.t.......h...s.spl...s....p..hs...ph..............p+h..........................................htuLpas.........p...l.pph.u...pph..lpchh.....................................................ts...s.alulHL.R..........h.c...D.h.........hptC....................t...h.tt.p...............................s..hph.psp.s.Ph.t..spts.....................shhhp..thsh...ps...................s..tl.Yl....Assp...................................hht..t.t.h....tsLp....phas.phh......p+ppl.h..s........p-...ht..h.t................sthA.t.lDhhlshpu-h.Flss....ss....hsthl.tcRphhsh.......phh.......................................................................................................................	0	207	476	627
+10083	PF10251	PEN-2		Presenilin enhancer-2 subunit of gamma secretase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3402)	Family	This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyses the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex [1].	25.00	25.00	25.60	26.00	22.70	24.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.28	0.72	-3.76	11	135	2009-01-15 18:05:59	2007-08-07 15:39:15	4	2	126	0	86	119	0	92.60	43	78.83	CHANGED	lPNEcKLpLCR+YahsGFAhLPFLWhVNssWF...F+EAFtKPuasEQppI+pYVltSAlGhhlWsllLoTWlshFQh..pRspWGshuDhlSFhIP..LG	...................ssEcKLsLCR+Yah......u.......GFAh....LPFLWhVNshWF...F+-AFhtP...sas..EQppI+pYVht....SAlGhllWsllLsoWlhlFQh...RstWGshuDhlSFsIPhG.............................	0	31	45	66
+10084	PF10252	PP28		Casein kinase substrate phosphoprotein PP28	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3375)	Domain	This domain is a region of 70 residues conserved in proteins from plants to humans and contains a serine/arginine rich motif. In rats the full protein is a casein kinase substrate, and this region contains phosphorylation sites for both cAMP-dependent protein kinase and casein kinase II [1].	25.00	25.00	25.90	25.70	22.80	21.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.03	0.72	-3.96	22	247	2009-01-15 18:05:59	2007-08-07 15:39:49	4	6	192	0	177	239	2	84.40	51	39.93	CHANGED	sNPN+ssppp.pphpp.....h..s............s.spLSRREREtlEtQpA+cRY.KLHspGKT-pA+ADLARLAlIRcpREtsAtR+EsEKct+	..............................................................................tNPN+st.pps..p.pssp......lshs.............................ssspLSRRERE.plEKQ...cA+...ERYhKLHttGKT-pA+A.........DLARLAlIRcQRE-AAt++EtE+ct+.....................	0	53	88	134
+10085	PF10253	PRCC	PRCC_Cterm;	Mitotic checkpoint regulator, MAD2B-interacting	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3903)	Family	This family constitutes the major, conserved, portion of PRCC proteins. In humans this family interacts with MAD2B, the mitotic checkpoint protein [1,2].\	\	\	\	\	\	     In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing [3].	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.47	0.71	-3.59	43	260	2009-09-11 16:00:24	2007-08-07 15:40:11	4	6	218	0	186	243	0	214.30	19	52.85	CHANGED	lsLFuLs............sspptsssssss.............tsussYpPhhhsspttts.tsst..sts.pstpsspsssps.s.tt................................t..........slutup+Rphht+t...............pspllchss-pph.ssspchhhpt.t.ct.sspt...p.sslpsht.................t.uKHpLppLlptApsp+-tLE-paAsuRpN++pAuuKYGa	...............................................................................................................................................................................................................................................................................shFuh...................................................................................................t........t.....................t..t..........................................................................................................................................hts.............thstpth+phhs+tt.t...............phpll-lssDcph...sss..p....p.h...htpths.tct...shps...thp..s...sht...................t++KHQls.Llpp........A.pppc.cLcppaups+hs++pspuKYGa................................	1	61	98	147
+10086	PF10254	Pacs-1		PACS-1 cytosolic sorting protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3709)	Family	PACS-1 is a cytosolic sorting protein that directs the localisation of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef [1].	25.00	25.00	25.60	28.60	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.53	0.70	-5.84	8	272	2009-01-15 18:05:59	2007-08-07 15:40:32	4	4	94	0	174	211	0	351.90	47	46.84	CHANGED	VYDQLNpILlS.DutLPE...sllLVNsoDWQGpa.....lu-LLQspphPVVCTCSsAEVQAlLSulloRIQ+aCNCNSpsPpPVKVullGuQpYLuAlLRaFV-pLupKo.PDWLsHhRFLllPL.GS.HPVAKaLGulDsRYSshFhDsuWR-LFsRsEsssosppt........................sDlluRIpQYlsG.AsssHQLPIAEAMLThKp+.............DEDSsQpFlPFlGVVKVGllEsspuo........G.D.-DusslS...........................tul.So.SPP...psoshuK-u.uTPP......................sSPShsuuhsu.uSPs....s-ulGLQVDYWsus.PsE+++.........-u-+......+Dt.ouKNTLKusFRSLQVSRLPpuG....puphssoMoMTVVTKEKNKK.....................................sshFLuKKsK-KEs-.SKSQsIEGIoRLICSAKQQQsh.LR........VhIDGsEWsDVKFFQLAuQWsTHVKaFPIuLFGtoK	..............................................lhDQLspILlS..Ds..tLPE...sllLlNssDhQGQ.h......lup...lLQpp........phP.l.VsT..sSss-lQAs.hssllo+IQ+aCNsNop.PtsVKlulsGuQpYhuulLRhF.V-pLupKs.sDWLsahRFLllPL...G................S...HPlA+YLuS.....lD.+Ys..shF.........D..sW+-LFp+.Es.ss..p...........................-...lssRltpYlsG....Ass..spQLPIAEAMLsh+pc....................DE-S..t.QpFlPFlu..s.VKVGhl.E.ssuss.......sDs-Dusss.s................................................................sl...So...oPP....pss..s...h....+.......t...s.so.PP.........................s.S.Puhs..suh..s..s...u..ps.........u-hhtLQVDY.Whst..s.s-c++....................cs-K.......cD..ssKNT.LK....ssFRSlQV.....SRLPpuG..........ps..t.h.s.ss.MuM.....TVVTKE......Kp.KK...........................................................hhhL.sKK.sK-K..-h-.......u.KSQsI-G.IuR..LICoAKpQpsh.LR..................................................V.IDGV.EWsDVKFFQLuAQWsoHVKaFPlslFuhs.............................................	0	34	47	94
+10087	PF10255	Paf67		RNA polymerase I-associated factor PAF67	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3677)	Family	RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67 [1]. This family of proteins is conserved from worms to humans.	19.90	19.90	19.90	20.80	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.43	0.70	-5.59	26	467	2012-10-11 20:01:01	2007-08-07 15:40:55	4	6	266	0	232	338	15	296.80	40	76.52	CHANGED	cpRhsSacNYssLFshll.......supss......................ssLpLPs..WlWDllDEFlYQFQshspa+s+htpps..t.................-cht.l...ttp.spsWsshslLplLpuLlp+SpIpp.hph.pts...hp..s.....hsssh...sspslhthLGYFollGLLRlHsLLGDYptALKsLcsI-l.s+cu.las+VsssaloshYalGFuYhMhRRYsDAIRhFsplLlalp+pK....p.hpppsaQ.stl.Kps-pMYtLlAIshsls...Ptp...lDEoltptl+E+.Yu................-chhp.lppu...shpsFc-lFshuCPKFls..Ps.ssshcss...h.........-shppQlplFhc-VppQptlsplRSYLKLYsolslpKLAuhh-l...................-s-.......................pl+s.LhshKpcs+pl.hhstu.slhcGchhss...u-lDahID............pDhI+ls-s+.st+pas-aFl+pltKhc	...................................................................................................h...s.....h.hthhtEalaQht.h..ap..................................................at......h.thh..hh..s.h.................................t...hhh.hGaauhlslh+hpslhGDa..ulphht....lph.t....................t...h...l..s.hsh.YahGas.hMhpcY.-u.p.h.thl.hh.p.p.............t..........K..-phh..LhsIsh.sht...........Ptt.............lD-slptthpEK.as.............................DKhh+.MppG...s..s...sac-LFsaACPKFlo..Ps.ss....sh-ts..sh.....................-shchQhplFh-EV+QQhhhssIR..SYLKLYTThslsK.LutFh-h.............s.p............................................................phph.LlshKp+hpph..W..s.u......u.........h..L-Gc...u.............s-hcahl-.....................pshlhIs-sc...tptatcaFhpplt+h...................................................................	0	87	126	185
+10088	PF10256	Erf4	QRDY; 	Golgin subfamily A member 7/ERF4 family	KOGs, Finn RD, Coggill PC, Bateman A	anon	KOGs (KOG4069 & KOG4101)	Domain	This family of proteins includes Golgin subfamily A member 7 proteins as well as Ras modification protein ERF4.	26.30	26.30	26.30	26.50	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.53	0.71	-4.23	32	473	2009-01-15 18:05:59	2007-08-07 15:41:10	4	7	230	0	323	429	0	117.60	28	53.06	CHANGED	hVtI.Rca....tsshhspF........ps.taPsp..................................L.psh.lstp-FcphlsplNph.LtcAhsshshpshl-shlsslT..hhlh.hhh.....hshhc+..................pLpclppal......pphNp....phhptpGl...pllsP+cpG.Lplsh	...........................................................................h.....p.h....stGhsspFpo...cFPsp........................................L...su+..lstp-FcpolpplNsh...htcuhps......hstt..shhts.hhsChT...hhh.hhsh.........................hshhc+............................................s.h+plp+hl......ppp.Np.....cla.t..........hG..L.............phh.shcps.h....................................................................	0	90	148	238
+10089	PF10257	RAI16-like		Retinoic acid induced 16-like protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3695)	Family	This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.	20.50	20.50	20.70	21.90	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.20	0.70	-5.52	27	432	2009-01-15 18:05:59	2007-08-07 15:53:27	4	6	190	0	274	417	1	336.50	29	42.16	CHANGED	CLEahLpcpIL-sLhpLuhs...shss...Gh+ppslphaspLlup.pps...lLsatsltRPlhcL......................................lphssps....usss........................Ep-hVplLpslCsplppcPtLLshahpspppp...................................................................t.t.sh....ttpssasLFshLlsas+pp........................GRlGphARcuLLhllshu.....p.shu...................................................................................palsp.oslss.......................lhustLu.uLYspLPppl....p..........l.uhsh.......tpp..................-hsths....tL.tFhuhLpasssllpps+s....................tlsssLhcthpptFL.slltPuLLpsS-...tuhhsshshLptlLcplspssLlcphlpFLLu................................ppp.t.....tth.lhppLlppps+ho.clshssh...tlh-sllttPspthLhsLlLcsL	.....................................................hhEahlpcpl..hpplhphuht.....chss......th+tp.lthaphLlsp.cps.....LLt.at.slhcslhpL.......................................lphsuts.......sssh.......................................Epch....V.LLst..lCsplt.p..c.Pt.lLphahpsp.p..t....................................................................................................................................................................................tstspa..LFshLlsal+pc........................GplGppAR-uLLhlhulu.....ts.shu......................................................................................................................................................................palsppo.hCs.......................ll...usG.Lu.uLY..opLPpplc...........................................l.u...s..W.....h.ttc...............................................Dh.ths..............tLstFhs.L-FCs...sllph.A.+s..........................................................l.tp.pLhchlp.ptFLhslhtPuLhpso.............................tphlssouYLch..............hL+.......pl.......s.......ps.sLlpph.lpFlL...................................................................p.pp................spts.......lhcpLlp+hsp.....c.lshsoL.......thFcpLlthsscplhhpLlLp.L.........................................................................................................................................................	0	79	115	189
+10090	PF10258	RNA_GG_bind		PHAX RNA-binding domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3948)	Domain	RNA_GG_bind is the highly conserved U3 snoRNA-binding domain of PHAX (phosphorylated adaptor for RNA export) whose function is to transport U3 snoRNA from the nucleus after transcription [1]. It is characterised by having two pairs of adjacent glycines, as GGx12GG.	25.00	25.00	27.60	25.00	22.50	24.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.73	0.72	-4.29	17	161	2009-01-15 18:05:59	2007-08-07 16:04:49	4	16	122	5	121	157	4	81.30	37	19.68	CHANGED	clsscluppLpE.+s-LlhRllpslG.phshpLhpEThpIppsGGhhsssGsR+RTsGGVFhtLlKp...p.plsc-phctIatc-+cpp	.............................lss-lu..h+LpE...Kp...cLltRlVphlG.c...tsl-LhpE.....Ttc.lEpsGG.....hhl....hsG......s...R...RRTPGGVFhpLlKp...p.plspcph+pIa..-pph..................	0	41	63	97
+10091	PF10259	Rogdi_lz		Rogdi leucine zipper containing protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3992)	Family	This is a family of conserved proteins which have been suggested as containing leucine-zipper domains. A leucine zipper domain is a region of 30 amino acids with leucines repeating every seven or eight residues; these proteins do have many such leucines. The protein in Drosophila comes from the gene ROGDI.	29.40	29.40	30.00	29.90	24.50	28.20	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.75	0.70	-5.29	24	229	2009-09-11 08:31:40	2007-08-07 16:05:10	4	4	203	0	164	223	0	258.20	25	80.33	CHANGED	ElcWLlcp.lpssLsplh-sLpcCsthLh..............tt.s.phsLSos.........ps-...plKGllTRsGstIsphslpl+h.................schsp...hhhph.s.sps.hhLpQlpsspstlspulsllsshpths......................phpstsplhp.lptlhpplppu+ptLp..........hPscss....hhh.tpssssp.........................FsPsLssp..............lulclhIspscLslpl+sLctlp.......t.hst....sshshhsplh.th...pp......................................................................................tsh-.hscshsa..ssps.................................................VhhpcKhpVposDPhLhushsKLsultphlpphhssLss	..................................................................................................EhpWllpp.lpssLtpLpchLp-....Ctthhs..............................................s.tptpphsloss.....................................ps-.pl...KGhlTh.Gstlspu...clpl+h......................s+tsp.....hphs..hp.sp..htLpQlpsspsplspulp.llsshptsh.......................................................................................phpsusplhphlstlhtpL.pcu+spLp.............hPts.s.....h..htsst.sp...................................................................FsPsLPss.............................lslphhlppscLsltlhpLcshp........................ss.h.sh...........tt.........................................................................................c..sthhpa...tsp.......................................................................l.lpchhcVps...P.L.sh.shhss..t.htphhttlt............................................................	0	40	73	126
+10092	PF10260	SAYSvFN		Uncharacterized conserved domain (SAYSvFN)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3249)	Domain	This domain of approximately 75 residues contains a highly conserved SATSv/iFN motif. The function is unknown but the domain is conserved from plants to humans.	25.00	25.00	28.10	27.60	19.40	18.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.42	0.72	-4.21	9	137	2009-01-15 18:05:59	2007-08-07 16:05:22	4	5	114	0	96	133	0	70.90	41	37.18	CHANGED	lhlllWllhhsluhchs.FGslFllhShhhhIahNhtp...RppGEhSAYSlFNcsscpl.GThsAEph-R-lt	.............h.hhllWllLhslhh..c.l-..FGhlahllShFhhl..ah.shcs.......t.+cpG........E..hSAYSVFN.sCcsl.GTLsAEphER-lp..........	0	35	50	77
+10093	PF10261	Scs3p		Inositol phospholipid synthesis and fat-storage-inducing TM	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3750)	Family	This is a family of transmembrane proteins which are variously annotated as possibly being inositol phospholipid synthesis protein [1] and fat-storage-inducing. The members are conserved from yeasts to humans and are localised to the endoplasmic reticulum where they are involved in triglyceride lipid droplet formation [2].	20.50	20.50	21.30	21.70	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.97	0.70	-5.33	40	321	2009-01-15 18:05:59	2007-08-07 16:05:44	4	6	218	0	223	312	0	213.20	27	67.70	CHANGED	.tshsY...ass+cNllNhhFVKpG.WhWTolhhhhh..lhhh.............ststtps...st.phh...............................hptlhRallsTlhWhlhTp...hh.h.slhDplhshTGGpCphssst...............................................................................................................houtsC+ptGGp...........................................WpGGaDlSGHsFLLshsoLhLhpE.............................h..htphhtsh.th.t......................................hhphhhphshhlsssLlslWhahLlhTslY..FHohhEKlsGhlhGhlshhll.Y	....................................................................sYhup+pNlhNh.hFVKhu.WhWTshhhh.h..lhhh........................shhhstt.....................................hhptlh+hslsThhWhhhTp.............lhstl.hhTG.pC..s.h...................................................................................................................t...hhoptpC+tt.GG.h...........................................Wp.............GaDlSGHsFlLshsshhlhpE..................................hth..htph.tt.t.....................................................................hphhhphhhhhhshlhslWhahLlhTsl.Y..FHshhEKl...hGhlhuhhshhhhY..........................................................	3	58	101	169
+10094	PF10262	Rdx	SelT; 	Rdx family	KOGs, Finn RD, Coggill PC, 	anon	KOGs (KOG3286) & COG3526	Family	This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding [1]. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown [2]. Selenoprotein W contains selenium as selenocysteine  in the primary protein structure and levels of this  selenoprotein are affected by selenium [3].	22.10	22.10	22.10	22.20	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.81	0.72	-3.95	82	990	2009-01-15 18:05:59	2007-08-07 16:06:05	4	6	744	31	497	872	69	87.60	31	61.58	CHANGED	sclpIpY........CspCpahhR............ushhsQ-LLpoF.ss.......t..clsl.....................................................................hs....us.sGs..F-ltls.....sp.....................llas+hpsu.....................GFPsscpLhphl+st	..........................................................................................plpI.Y...........C..tp....Cp.ahh+.................ushhupcLh.psFss............tl.t..pV..sL............................................................................pP.....so..uGs.FElpls................sp.......................................hlW...s+pp.sG.....................GFP-sc.tLpphl+s.h............................................................................	0	167	270	391
+10095	PF10263	SprT-like		SprT-like family	Finn RD, Coggill PC, Bateman A	anon	KOG3931, COG3091	Domain	This family represents a domain found in eukaryotes and prokaryotes.  The domain contains a characteristic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.55	0.71	-4.57	148	2631	2012-10-03 04:41:15	2007-08-07 16:06:41	4	16	2330	0	664	2121	615	152.10	24	66.24	CHANGED	lpphhpphspph.aps..htt.........plpas...........chppsAGp........shhppp..................................................................................pIcls.hllpp......spp..tlhp......................slhHElsHhhhahh..........tcspsHGs.ca+thhpplss.....................................h..phhcpass.p........................pahapC............................sCst.h..tpptpl..cppp.....................................................................atCt.......................pCp.uplthhp	................................................................................h..thhtphs.phFtp...hp..................pltas..........................................pht.o.ouGp..................hh..hcst.....................................................................................cIc.lNshlhpc................spp....hltp......................llhHELsH.hhlaht..............t+st.H.sc...-...........a+thhppVhu............................................................h.sp.hhcpath.p...........................tpa..YpC.....................................pC...p.................+p....tp....l....p.hpp.........................................................................................apCs......................pCt.tpLh...h....................................................................................................................................................................................	0	194	353	536
+10096	PF10264	Stork_head		Winged helix Storkhead-box1 domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3897)	Family	This is the conserved N-terminal winged helix domain of Storkhead-box1 protein which is likely to be a DNA binding domain. In humans the full-length protein controls polyploidization of extravillus trophoblast and is implicated in pre-eclampsia.	21.20	21.20	22.50	21.40	21.00	19.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.43	0.72	-3.80	8	151	2009-01-15 18:05:59	2007-08-07 16:06:58	4	4	78	0	92	140	0	78.10	53	9.84	CHANGED	MoPIsQSQFIPLuElLCssISDhNusphsVTQEsLhp+LpppaPGhshPSp-lLYsoLusLl+ERKIYpTucGYFIVTPQ	........MoPIuQSQFlPLuElLChAISsMNuAppsVTQEuLhE+LsppaP.G..ls..sPSpElLhpTLspLl+ERKIY.Ts-GYFIVTPQ................	0	20	29	55
+10097	PF10265	DUF2217		Uncharacterized conserved protein (DUF2217)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3831)	Family	This is a family of conserved proteins of from 500 - 600 residues found from worms to humans. Its function is not known.	25.00	25.00	36.90	36.70	24.70	24.00	hmmbuild  -o /dev/null HMM SEED	515	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.62	0.70	-5.74	11	211	2009-01-15 18:05:59	2007-08-07 16:07:11	4	6	90	0	112	184	0	382.80	38	89.17	CHANGED	hshushstl+los.utK+llhusAhGsluLhhhA+pL+RR+t++c.......t...hh..........op+s.ut+tspsoupR.p......sssscsNDshSsluSttsuKpSuSupSluShpshpSsussuss..ussW-sts..p-sh...sssssosEsLYlMGMELFEEslppWEpALsh+pctst..u.hs.................sspst-Fsc+LEsLLptAYpLQE-hphhh...cssshh...............sD....c+shthshhststshptscssSlsSsDSFhSAsElh....-ph-hp..shsh.shc.tshYEEALpLsc-GcVsCRoLRTEhLtChoDsDFLAKLHCVRQAFpsLLpDcsNphFlu-sGRQlLouLls+AcKsPKcFL-uYE-MLpalpps-sWssschELEuRGVpsMsFYDIVLDFIlMDAFEDLEsPPsSVhAVlpNRWLSsSFKETALsTusWSVLKuK+phLKsP....sGFhuHFYsloEplSPllAaGFLGP+ppLp-lCsaFKcQlltFL+DlFDh-KVRYoolEpLAEDILplh+RRs-llhsYh	.........................................................................................................h.......h..s..sh+hlhhshshush...h...hhup.h+R+t..................................s.h....h.t.hstpp...................ss.ppss.p..hsh.hs.u...u+..suss........tShh......uh............h.S.t.ss.s...s.....hpt.s...t..h.......h..hssppL..hh...GMEhhEcslppWEpALsht.pp...t.t....s............................................................................................p..ptcFhcclpsLLptAYpLQ.Epht...h...h....ss.hh.......................D....cps......hshtt...s...t....ht..t.sp..shsSt-SFh..SAh....E.h....-.hpht..t...h.....p...hshYppAhphsc-spl.sR......sl............R...o-hhtC.uDt-aLAKLHClRpAaphlhp-....tsp.ahscsG+phlssLhhhup+sPKtF..sa--Ml.ah.pspp...a..sphp.ELtsRG......VhshsFaDllLDFILhDuF-DL-sPPsSl.sVlpNRWLssuFKETAlsouhWSl....L.K..tK+p.hh.hs....sGFhuHFYslsEplSPlhs.aGFLGP..p...pL.-lCthFK................pQll.aLtDhFshppsRaooh.thucDlhph..pRsp.l...............................................	0	32	39	75
+10098	PF10266	Strumpellin		Hereditary spastic paraplegia protein strumpellin	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3666)	Family	This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteristic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies.	25.00	25.00	45.20	32.30	21.50	23.40	hmmbuild  -o /dev/null HMM SEED	1081	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.63	0.70	-7.15	12	186	2009-01-15 18:05:59	2007-08-07 16:07:20	4	5	115	0	130	181	15	759.30	41	92.15	CHANGED	soIIAElLRLupaIPp.F...s+t-ppcYucIl.hDFpYFptt-thEscIpps.cL.pLDE-h+poal.llpRFatlFcSlacYhhDLppal-ElppGhalppTlEolLpst-GKQLlCEulYLYGVMLLlhDhpIsGhlRERlLVoYhRY.....+usu-.sNhs-VscLhRuTGYsssss.s............................sYP.pYFsRl.lscphIshlIGRlRoDDlYp.ht.YP.P-HRSsALusQuuhLYVhLaFsPplLpspsuhMREIVDKaFsDNWlIsaYhGhTVsLhsAWcsFcAA+sAlpNTls.pslp.hhp+hppphsplhsphpplLpEGhLsEphlLDslp.plhshlR-sNVslRWlhLH.......................spppt+pspphl.h..phspcplhpLLLsouQhEhpl+phhpslLppKpp+Wpcs+cpusp+hpcLuchFSGs+sLscsppsppLppWFtplupcIppLshs-s..stuuRpI.pLlpALEpVp-FHQlssNlQVKQalt-TRphLppMh+hlNIc-csLhplthluDhSYAWclls...sasshMQppI+ppPphslplRusFlKLuShL-lPhlRIsQupS.........D......L.oVScYYSsELVsFlRcVLpIlPpohFslLtpIIpl.TNsl+EhPo+L-KcchK-aAQh-pRtpluchTtsIuhaopGILAMcoTLVGlIclDP+QLLEDGIRKELVppIscthapsLlFs..........t....ptpssphppcLspLupplcGhRpSFEYIQDYVNlpGL+IWp....EEhsRIlpapVEpECNuFl+pK.l.t..WpSpYQSp....IPIPpa.sh....stpuhsFlGRLspcllplT-P+solals.hsuWa-hcs.hpEVlus+.hauplpcslGshGLsuLD+Lhuahls+cLpphlpphpttl...-pthhsslpsltspLp....stsshscp..shchYtphhpphpthh......................splhthlhplGQhQllRppIutcLphpsKlcSspL.ssLcshNcAlLtD.lppHh...........ppspopPhPsp....llsslssaLpssGlp-PhpKlY..........................................hsscshPph.slhLhlhsLtpl..s+hpascplsshls.pctps....lDspsLhlGlhslL+QFpspppphaLsaluQal	......................................................................psllAElhRLtphlP..a.........................ttt..cat.ll.hDFpYhp..-.h-t..plptp.tL.tl-cchhps...hlpRFa.hFpulhtYh.-l...palp-lt..p...Gh...alp.oh-slh.s.cu.pQLh......sEshaLaGshLLlhD.ph.G.lRERhlluahRh...................p..pss...sphcclstL..h+sTuh........................................................................s.........pYPpt...aFtRh.hsp...hlphllupl+sDD..lYpt....a.P.Pp.HR.SsALu.QuuhLaVhLaFts.phLpsp.shMREIVD+aFsDNW..l................lshahGhslsL.........t........WtsacAApsAlttslp.t.tlp...htp...t.....tp...p......hpthlpcG.....lppphl.....lp.ph..plh.hhRpsNsslRWhhLH...........................tt.pphtp.l.t.....thp..t.lhpL.LLpsuphEh.l+phhtphLtp+ptpWtt.+pps.pph.cLuphFuG.hs.L.sp..pstpL.tWF.phupp.........l.pLphtp....ttsuRhh.plhpALcpVppacplptshplpphlt-opt.LppMh+hlslp-chhhphphlsDhSaAWtllp...tah.hhQptI+.pPt.shtl+uhFlKhu......Sh.......L-lPlhRlsQspS.........D......L.sVSpaYSs-LssalR.pVLpllPpohFt.L.plh.l.sp.hhc.hPs+lpKcc................l+cauQht.Rhpl.AphTttluhaopGlLhMcpThlGllc.lDP+pLLEDGIRKELVppls.thpt...L.Ft.....................................t.t.h..pLtthut.hpuh+pSFcYlpDYlpl.GL+la.....EEhpRIlphtlptEsp..sFhppp...h.....p..app........hshP.h..........t.u....sFhG+LhppllthTs.sp..ohahp.h.sWa.........p.ps..........p-lh.s.p.hhs.ltpslu..GlsuL-plhshhlsppLp.h.lt..htt.l......h.thhtth.ttlt..................s.....th..tt.....phY.thhtthtt.h.......................s.hhphlh..plGphQllRp.Is.pLp.ss+hcup.L..sslpshNpull.p.ltt................................................................t...shstt......hl.plpthLphsGh.pPhpplY..........................................lp.s.p....h....h..shh.hlhhlspl..s+h.astp....hs......hh..tt..ts...hD..shhhGhhslLpQFp......hlthhs.h.................................................	0	57	72	102
+10099	PF10267	Tmemb_cc2	Tmcc1; Transmemb_cc2; Tmemcc2; 	Predicted transmembrane and coiled-coil 2 protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3850)	Family	This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.	23.30	23.30	23.30	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.27	0.70	-5.88	15	351	2009-01-15 18:05:59	2007-08-07 16:07:43	4	5	107	0	168	289	1	324.30	46	73.96	CHANGED	+s+tsh-pLpQKILcloEQl+lEQsARD-NVsEYLKLsss........ADKQQsuRIKQVFEKKNQKSApoIuQLpKKL-pYH++LKElEpss...........tppP+-sl+-hppuLK-sssp.p..........httl+s.hsGhS........hVhSKPREFAsLIRNKFGSADNIsphcs...............................s..Lc....shtsEp..ss+uLuuuu.ohsspsKYsSD-..-CSSsouu.Sssususps........................psstpsspsslstlhEELpEI+csQupLc-sh-sLKsphp+DashlspoLQEERYRtERLEEQLNDLTELHQNEhsNLKQ-LAohEEKlAYQSYERARDIpEslEsCQTRISKLE..pppQQQslQLEuh-p.pAR..sLLsKhINllLuLhsVlLVhVSTlAshssPLh+oRh+lhsTllhlhllshhW+pWcpl	.........................................................................................+.shspLpQKILKloEQI+lEQpuRD........sNVuEYLKLsss........A.DKQQ.suRIKQVFEKKNQKSApoIuQLpKKL-pY+++L+ElEpsG............cpsK-sh.+DhppuL+-stup................s+suhsuhS.s......................shVhsKsREhAs.LI..RN.KFG.SADNIspL+s.....................................................................s..h-....ph.s-t.......usps.hus.u..sh.s..psKYsS--...-C.SSsouu.Sss.us...uspu......................................tshh..tttthphlhcEl.pEl+cspspLp-shEsLKtp...hp+-.h...s....hh.psLQEERaRhER.LE-QlNDLT-LHQpEhhNLKQcLAshEEKlsYQuhERuRDIp.EslEsC.TRloKhE.......ppQQsl.........Qh.-shp.....A..+....sLLsKhINl...lL...slh.sVlLVhV.SThAphh.hPhh+o..........R.......+hhsThhhlhhlhhhh+pWtt.h............................................................................	0	31	46	87
+10100	PF10268	Tmemb_161AB	Tmem161AB; Transmemb_161AB; Tmem161AB; 	Predicted transmembrane protein 161AB	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3978)	Family	Transmemb_161AB is a family of conserved proteins found from worms to humans. Members are putative transmembrane proteins but otherwise the function is not known.	18.30	18.30	18.60	18.50	17.10	18.20	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.81	0.70	-5.98	8	239	2009-01-15 18:05:59	2007-08-07 16:08:00	4	7	107	0	142	235	2	324.50	35	90.47	CHANGED	AllGlQLVVTLlhsSlhQKluPHaSFARWLLCNGSLhRYpHPTE-ELRsLAG..KQK..sK.u++-R+tNG....ssEsKPholPKDIDlcL-TpPlsshDsLsLRaFsEYQWLlDFuVYuslVYLlTElYahhhssscEhNISllWCLLVlhFulKlLhoLTsaYFpSEEG.GERSlCloFuFhaLLlAMlVLlVsEchLEhGLEsG...............asShssshpsFLcpQGLpsuu........PhoKLshKlhLAVhCuhLGAhLTFPGLRLAQMHLDALphspD+.hlQhLLHlSFLsPlllVlLWlKPIsRDaLpssshG+.SssLhSsssF-TLRLWlIllLCVLRhslhRhHLQAYLNLApcpV-QMKKEAGRIoslElQ++luRlFhYLCVVuLQYlAPllLsLahTLhLKTLGsaSW.GlhsEs...s..sh.ssscsuPlss....................t-s-t......phpsTstplpsuhuSL+slFTPllaRGlhuFLTWWlusC.FsoSLFGlaYHQYLstu	.................................hhhh.hhp+h...hhshhchllsps.Lhha.hPo..-ppLp.hss..........p.........p.tt.+p.p........pt............t..hplP+.sh....hpL.pp..l..h..Dhl..h..ha.p..h.ahh.h..h.s...hhlhhh...s.th.h..hh...................tp.....h..Nls..h.h.a.hhhsh.................a.s.h..p..h...l...hhp......................ps..hEpshhlshshh.hhlhuhhh..hhtcphh-hslp.u...............hs.shspsh...hhpppGh...t.....................P.h.sc.l......hh+h..hL.Ah.hs.uhlGuhhsF.PulRhAphah.......D....u.......lp.......h.....p.t.p.hhp......h..lLphsal.PhhhlhLWh..................+Pls+p.hlh...............................ht..t...........................l.......h....s......t.apphRlhhllhhshh+hhhh....hLQuYLshA.tth.p.+p.cuGpltshp....hpp.hl...hahYlsllsLQahs.Phlhh.l..hs.hhh.p....t....h.s...t...hs.h......................................................................................................................................................s....................................................................................................	0	45	63	105
+10101	PF10269	Tmemb_185A	Tmem185A; 	Transmembrane Fragile-X-F protein 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3879)	Family	This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B [1].	22.90	22.90	22.90	22.90	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-12.19	0.70	-4.76	13	397	2009-09-13 05:38:14	2007-08-07 16:08:33	4	14	158	0	224	366	7	149.00	22	56.90	CHANGED	L+LDshlsWSaWhVFsPlW.haphllhhGuhlssss...........tspscahAhllulshpLlLlsFplLlC.pL.......tssshsWplVFlPL...a.hhpshulhthlhsh+a..............DcuhphphhahhshlphlF...........lhLKL......DsllshsWhlVFlPhaIshshthlhs................lahlhhsl.hhscs.plhsspccpphts.ulss......hhhslPhlsFpllLst+L-sss........plshhslFsPLhls	...............................................................................................................................................................................................................................................................hl.phlh.............lsL+L......-.p.hh.....h.....sWhh.l.........a.lPha.....lh.s..hhhl..hh.........................................hh..hh.h........................................................................................................................................................................	1	74	105	163
+10102	PF10270	MMgT	Tmem32; Tmemb_32;	Membrane magnesium transporter	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3918)	Family	This entry represents a novel family of membrane magnesium transporters (MMgT) [1]. The proteins, MMgT1 and MMgT2, are localised to the Golgi complex and post-Golgi vesicles, including the early endosomes, suggesting that they may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells [1].	21.20	21.20	21.30	22.00	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.34	0.72	-3.61	35	278	2009-09-21 12:36:32	2007-08-07 16:08:55	4	8	246	0	200	267	1	99.40	28	72.23	CHANGED	lhhlGhlhLhHuuYSuh..pa+phh+h.......sp......shssLPhDIllEsllulllhhhGllhsstph+.lph...............htclp....................pssaspl...............psRsuFhshpp+p+tht	..................h.hhlGhlhLhHAuaSuh..pa+shh+h....................spp......phpsLPlD.IllEslluhllshhGllhss.sch+slph.................ssclp...........................ppsassl...............pscsuFhshp++t+.h..................................	0	59	106	163
+10103	PF10271	Tmp39		Putative transmembrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3828)	Family	This is a family of conserved proteins found from worms to humans. They are putative transmembrane proteins but the function is unknown.	19.70	19.70	22.50	21.90	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.59	0.70	-5.82	11	215	2009-01-15 18:05:59	2007-08-07 16:09:16	4	3	90	0	111	180	0	321.40	44	87.45	CHANGED	uSuhGhSsPPlss..T...l+Hs.IP-lshs.upLlFEhhlFhapllALhlQYlNIY+TVWWhP.Sa..s+pSLNFHLIDapLhsFIslhLuRRLlasl......lpcsspuspsohhpplhhll....s+hslLThsshoLshohlpLF+saShlsLLFLsYPFshYlslhshph-.p.st...t..................ushhc.sp-ah.hLRchh+pp...ls.t..shPsHuCs......SPshIRsEV-tLKsDFNtRhKcVLFsSlLoAYYVuFlPshFVc..........................ss.YYDhhWoCpphlhVhluuhlhLhsaLLPs+YCDLLHRAAsHLGpWQ+l-......stssssspHsWS-pslWPQGVLV+H.s+slYKAlGhaNV....AlPu-sSHhRFahhFppPLRllNlLhslEsulllYQLaSLh.poccWppslSluLlLhsNYashFKLLRDRllLu+sYuh	.................................................................................................................................................................hss..s......pHs.hP-lshp.upllFEh.hFhh.llALhlpYlNIY+TVWWhP.sa..sppulNFaLID..lhhhhhlhL.uRRhlhsl.............l.ps...pts...t...ph.p.hhhhh.......h+hslh.shsthsL....s.h...shhpLapsaohlpLLaLsYP.hshYl.hhthp.-.....................................................................................ph..hlhp.....p.hcp....h.....shPsHsC.sh.....sPs.IRpEVEhL+hDFNhRhKclLhsS..........hhoAYYsuFlPhhFV...........................ss.a.aDh.hWus.phhlhV.lss.shhht.L.hP.sp...YsDl....L.H+uAhHLGpWp+l-.............s.hsss..tp.WoctshaspGslV+H.spslY+AhG..hsl....AhPussSHh....RFa.............hhF......ppPhhll..shLhhlpsullhhQlh.Lh.topcWpphlShullhFsNYhshFKLhRDhllht+hYp..............................	0	28	37	73
+10104	PF10272	Tmpp129		Putative transmembrane protein precursor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3899)	Family	This is a family of proteins conserved from worms to humans. The proteins are purported to be transmembrane protein-precursors but the function is unknown.	21.80	21.80	22.30	23.20	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.12	0.70	-5.73	10	123	2009-01-15 18:05:59	2007-08-07 16:09:26	4	4	92	0	81	123	1	279.90	38	90.95	CHANGED	hChVFPPsEFhS.AGLTVpsLhStaLGSEDhuFVpYHlRRTo...ssLLsHShLPhGY....althshhAsppshhpstpss-........sWphhhhh.....uVllsllsuslsaYWSp+sWspHPlsKsLuhauhspu...sW+AVASuINTEFRR.-KFspthsu.o+VlVT-oWllKsTsYplclApQpDl+L..........................oVscS+pH-lo..sDsspslQhlsIpVsshsPt.lcPFsIRLNus-Yt-LpE+LcsPIpssuNVslHpols-cFlEsF+upVctNssaphs...sspEhEPCluCMQspssIKltKpC.sp-p....pG.......cCQsCYCRPMWCloChuKWFASRQ..Dppc.-TWLuu+ssCPTCRA+FCIhDVChl	................................................................................................shlasPpEF.t.hGhTlpplh..utaLGpEphsFl.aHl+Ros...hslhhHohLPhuY....hhthp.hhstpp..h........t..............aphhhhh.....ulh.h.shhsshhha..h.Wp..ppWtpHPls...+sLthas..s..t...................sapsVAssINsEaRch.D+aththsu.u......pllsT-sWlhKsosY..plphApQpDspL..........................sVscucpaplo...-.....ss...slQh....lsIpVt..s.........hpst..lpsFsI..Rlsuh-atpLp-+lptPIt.s.tsl.h+.pol.-hFl-sFtp.VthNshaphs.........................t...ph-.ChuChp..ttsslKl.K.C.p.st........tG.........pCppCaCRPMWC.......lpChu+WFAuRQ..s..c.....-.hWLtu+ssCPhCRupFClLDVshl.................................	0	34	39	63
+10105	PF10273	WGG		Pre-rRNA-processing protein TSR2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4032)	Family	This entry represents the central conserved section of a family of proteins described as pre-rRNA-processing protein TSR2. The region has a distinctive WGG motif but the function is unknown.	21.90	21.90	22.10	22.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.56	0.72	-3.89	34	320	2009-01-15 18:05:59	2007-08-07 16:09:44	4	7	273	0	236	319	3	83.20	33	40.01	CHANGED	hFppulshllppWsuLplAVpNs.WGGscSp-Kp-hlsstlh-hFss....................................spsh-..tp-lE-hLhphMt-EFss.slEDsSshpVApt	.........FptulphhlppWsuL.plAV-Ns.WGGs.....p..S..pcK...t-alss.slh-.hFtp..................................................sp.s.sc..hp-lE-hLhphMssEFcs..lEDsSh.pVAp.........................................................	0	78	130	195
+10106	PF10274	ParcG		Parkin co-regulated protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3961)	Family	This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system [1].  Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.27	0.71	-4.38	21	338	2012-10-11 20:01:01	2007-08-07 16:13:17	4	16	140	0	236	318	11	152.70	38	43.48	CHANGED	opFRthYsRGDlPlplpHuust....pc..ltW..+lsscpLDYc...hYLPlFF-GLpEpcaPYpFlAppGsh-LLpp............utpKIlPllPpLIlPlKsALsT+c.clhpssLclLQpLVhsushlGtALVPaYRQLLPlhNhapt..+p......hNhGDtlca.....cpppsluDlIp-TLchLEcpGGsDAaINIKYMlPTYpS	......................otFtthYp+GshPhtl.assht......pp..ltW...........cs......c..pLs...ac...hhLPlFh-GLpEhppPYp..FhAtpGhp-hLtt............uspK.llPllPpLIhPlKs...............ALsp+s.plhptsLpsLppL.........u...p..........hlG.tALlPa..aRQl....Lshhshhhs...hp....................................s...u.p.h........ptpppht-lIppTLphhE.hG.........G...s...uhh.IK.hlPTYpS............................................	0	104	134	186
+10107	PF10275	Peptidase_C65	Otubain; 	Peptidase C65 Otubain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3991)	Family	This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.95	0.70	-5.02	33	450	2012-10-10 12:56:15	2007-08-07 16:16:48	4	8	244	24	284	557	7	211.80	28	59.13	CHANGED	pttsphPh.luph....tshssLtcEYspt.sssahpKh.........ptLppp..YsthRpsRGDGNCFaRAhsFuYlEhLLppps......chsc.hhpplp..phpppLh.....thGhschhhcDFh-thhpllcplpstspts.......pllptasctstSs..........llhahR..hlsSualpppsctapsFl.t.........holcpaCppplEshtpEuDcltItALupuL....slslcVhYlD..............................ps....ssspsspash..................p....................ttshI............hLLYRPGHYDILY.	............................................................................h.lut..........l.t-a.t....s.......hh.tKh..................ptLtpp....ashhRps+sDGNCFaRAhhauahEtLlpptc......................chpc.hhthh.t...p.pptl............................thGa...tph.h..h.csF.hpthhpllppl...tpttp.s.................pLhp.h..Fs.cp.s.h.Ssh.............................llhahR...LlTSualppps..c...h......a.p...Flps...................hslcp..aCp...ppV...-shtp....Es..Dcltl..hALspAL.............slslpl...Y.hD..............................ps...........tssths.a.hs...............................ts................................ststl............hLLY+P.G.HYDILY..................................................................................................	2	105	150	216
+10108	PF10276	zf-CHCC		Zinc-finger domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3456)	Domain	This is a short zinc-finger domain conserved from fungi to humans. It is Cx8Hx14Cx2C.	21.20	21.20	21.20	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.29	0.72	-4.11	37	906	2012-10-03 19:45:42	2007-08-07 16:22:25	4	3	865	3	386	717	277	40.00	35	42.20	CHANGED	ss+plsC-G..........us.....ss......hGHP+Valslsppst...hhCsYCup+ah	...................................h.CsG..........st.....ss......huHP+Valslsc.psp....stCsYCGphah......	1	115	224	304
+10109	PF10277	Frag1		Frag1/DRAM/Sfk1 family	KOGs, Finn RD, Coggill PC, Bateman A, Wood V	anon	KOGs (KOG3979) & KOGs (KOG4320) & Pfam-B_15139 (release 21.0)	Family	This family includes Frag1, DRAM and Sfk1 proteins.  Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans.  There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function [1].  Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced [2].  This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton [3-4].	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.49	0.70	-4.86	89	980	2012-10-01 21:22:51	2007-08-07 16:52:53	4	16	284	0	645	961	31	204.50	18	57.40	CHANGED	shth....lslhtslhshsshlhshhhuhh..p.hhphs...........................hP.ISs..hGshsPcptlaphhhslsuhhthhlhhhtahh...............................................hhthhppt.....................lshhuhhhGllss.lulshluhh......sssptt.slHhhhhhhahshshlahhhpshh.hhht............................................ttphshth+hhhshhshshhlsh.................hhhhhhpphh........................hhshsAhhEWhlshhhhhah.hohhhDFtsh	..........................................................t...hlshhhshhshsshhhs.......hhhuhh..p..hh.p..s...........................................................................hP...l......Ss..hG....shs.P.pphlathhhshsuh.h...........t.hhhhhhhath.....................................................................hht..h...pp.t........................lshhshhhuh.lss...hul.hhlu.h.....................................ppsp......h.....s..........l...H....h.hh.hh..hhssshhahh..hpshl.hhht.............................................tth..hs.hhh+...h...h..hhhht.hh..shlhh...........................................h.h.hh..httt...............................................hhshhAhhEWhlshh.hhah.hohhh-Ft..h......................................................................................................	0	196	297	503
+10110	PF10278	Med19		Mediator of RNA pol II transcription subunit 19 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4043)	Family	Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators [1].	25.00	25.00	26.20	26.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.35	0.71	-4.60	7	119	2009-01-15 18:05:59	2007-08-07 16:53:34	4	5	92	0	79	112	0	161.60	53	58.81	CHANGED	uPFYLh+.E.Ps.sELTGspNLlscYsLEpuasKFsG.KKVKEpLSsFLPcLPGhIDhsGo..-NSSLRSlIEKPPIsGpph.PLTus.LsGFRLHsGPLPEQaRhh...+hp.Pp+KpKpKHKpp+sp-...shs............tpossDo......-+K+KKpK.+-DD.-RKK+KK-KK+KKpR+oP-p.ssG.	...................................................tPFYLh+..E.P...u.p.sELTGuTNLloaYsLEcuY...sK.FCG....KKl.KEcL..S..sFLPcLP..GhIDhPGsp.D.NSSLRSLIEKP.....PI.hG..pshsP.lTushL....s.GFRLH...s.....GP...LPEQ..hRhh.........................chp.Pp+K..p..KpK...HKpp+ppD....sss...................p.ost.Ds.......-.+.K+KKpK...+c-D..-..RK++KK...-..KK+..KKp.+cosc..s...s.........................................	0	25	31	58
+10111	PF10279	Latarcin		Latarcin precursor	Bateman A	anon	Bateman A	Family	This family represents the precursor proteins for a number of short antimicrobial peptides called Latarcins. Latarcins were discovered in the venom of the spider Lachesana tarabaevi [1]. Latarcins are likely to adopt amphipathic alpha-helical structure in the plasma membrane.	25.00	25.00	25.20	33.40	24.90	22.60	hmmbuild  --amino -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.80	0.72	-3.79	7	14	2009-01-15 18:05:59	2007-08-08 11:04:13	4	3	1	2	0	16	0	66.10	32	75.41	CHANGED	TuYsVsE-LEs.ELD-L-............................ttuh.......................................................................................LtchsEsLc.l-Dh.p.EEARu.hhthhKcchKchhpphhc+h	.puYsVsE-l-spEL--hpttuh...............................Lt-hsEpLctlpsh.p.EEARu...t.h+chh+phhtthhph..	0	0	0	0
+10112	PF10280	Med11	HSPC296_Med11; 	Mediator complex protein 	KOGs, Finn RD, Coggill P	anon	KOGs (KOG4507)	Family	Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organisation is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans [2]. Med11 appears to be necessary for the full and successful assembly of the core head sub-region [4].	25.20	25.20	25.40	27.30	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.40	0.71	-4.05	25	234	2009-01-15 18:05:59	2007-08-09 09:12:30	4	2	208	15	169	229	0	118.80	24	78.35	CHANGED	sp-RLcuLs-IDpcIsplLppAupslppLup.pp........................ts+pthpppsppFhpoLspVsspLR+pIphL--ssss.scptssh....................................................................tsLsls.lsp+psshs+c+LpEhhpp.hcphls	.......h.t-RlppLscI-+.....cIsp.lLppAupsltpLuppps.......................................pp..pthcpp...sppFh.pslp.p.l-scLpcQIphLscsshhpscpsssh................................................................................sshcs.s.hsh+p.hphs+p+hs-lhpp.hpph.....................................................	0	42	81	131
+10113	PF10281	Ish1		Putative stress-responsive nuclear envelope protein	Wood V, Coggill PC	anon	Pfam-B_11056 (release 21.0)	Repeat	This family of proteins found in fungi is a putative stress-responsive nuclear envelope protein Ish1 [1].	24.10	24.10	24.10	24.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.60	0.72	-3.86	71	642	2009-01-15 18:05:59	2007-08-09 14:52:20	4	9	141	0	466	616	0	37.40	36	30.74	CHANGED	acsWos..scL+paLcp....aGl.sspst......s+-cLlpts+csh	.....a-sWSc..ocLKpaLcp....pGlssspss......pR-cLlsts+cp...............	0	129	251	391
+10114	PF10282	Lactonase	DUF2394; Muc_lac_enz;	Lactonase, 7-bladed beta-propeller	Wood V, Coggill PC	anon	Pfam-B_1372 (release 21.0)	Family	This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway.\	\	    Structures of proteins in this family have revealed a 7-bladed beta-propeller fold [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.00	0.70	-5.37	81	4118	2012-10-05 17:30:43	2007-08-09 15:02:03	4	86	2565	28	1191	3490	508	268.50	22	71.36	CHANGED	phalGoYTp..............ttupGIathpl...sspoGpLsshph.ss.....phssPoaLsh..ptssphLYulscts.......spGulsuaplsspp..upLphls......ph.s..tGssPsalulstssphlhsANYt.......uGslsVaslssc.Gslttssp.hhppp......Gs..GPp............pcQcssHsH.sshoPcscallssDLGsDclhhYch...sssst....Lst...hsph.pstsGuGPRHlsFps...s...................sphAYllsELuupVslh..pYs..tsG..ph.pplpslsslPt..s.hsup.....................s...tuAuI+losDG+FLYsSNRG...................psSIulFslstssGpLphlpthsotGph..PRcFsl.sssGcaLlsusQcSss.lslapRDspoGpLs.hsps.htsspPs.................sVhF	.........................................................................................................................h...........................ttl..h.h.......t....t..t...t..ht......t...h................t.s.t....h.....h...h...........t..........t...t.h...l.ash..t.....................th..sh.t.ht..............t...hs..................t..................st......s.a.l..s..h...t....t..t.p..h...lh.....s.....u.s...Yt........................tu..h...h.h........htt...u...............................................................................................................s...ts....H..h....h.sP....s....tp..hl.h.s....s....s....L......t................D.p......lhh...ap.h....sttt.............h............h...th.......G.s....G.......PRHh...s.Fps.........s...................................................tph.hYl.h..s..E...l...s.....ss....lslh...........phs.......ps...............ph....p...h...p.p...hs...hhst......s..hsst.................................................p......tsu.s.l..p..l.....o.....s.....D.....G.....+.....a.....L.Y.s..us.Rs............................................tss...l...u..l..a....s......l............t....s...s........s.............p...............L....p.....h...l.....t..h..........h.........s......o.....t.....G..p......................P........R.........s......h.....s...l......s........s......s..............u.....c.....hL.h.....s......ss.p...p..o................s...s....ls..la..p..h..s.....pp.G.....lt.................ts............................................................................................................................................	0	394	731	968
+10115	PF10283	zf-CCHH		Zinc-finger (CX5CX6HX5H) motif	Wood V, Coggill PC	anon	Pfam-B_93850 (release 21.0)	Domain	This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.	25.10	25.10	26.40	26.20	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-6.99	0.72	-4.10	22	261	2009-01-15 18:05:59	2007-08-09 16:02:15	4	30	96	6	185	282	0	25.50	48	7.07	CHANGED	PcC.YGspCYR+NPtHhpcasHssps	...pC.YGspCY..R.KNPtHhpcasHPs.......	0	82	94	142
+10116	PF10284	Luciferase_3H		Luciferase helical bundle domain	Bateman A	anon	Bateman A	Domain	This domain is found associated with the the catalytic domain of dinoflagellate luciferase . Luciferase is involved in catalysing the light emitting reaction in bioluminescence. The structure of this domain has been solved [1]. This domain has a three helix bundle structure that holds four important histidines that are thought to play a role in the pH regulation of the enzyme.	25.00	25.00	26.60	58.10	18.30	16.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.38	0.72	-4.02	7	51	2009-01-15 18:05:59	2007-08-09 16:29:47	4	3	14	1	0	49	0	65.80	70	21.82	CHANGED	CEK.GFEsusssKGGALsAtpVE+hG.-sFKsGLHpPpFHs-GLHKPhEuGGKsYETGFHYLLEsHE	CEKTGLEuGGsu+GGALNAAQVtHLGc-sFKsGLHKPcacsEGLHKPHThGGKTY-TGFHYLLEAHE	0	0	0	0
+10117	PF10285	Luciferase_cat		Luciferase catalytic domain	Bateman A	anon	Bateman A	Domain	This domain is the catalytic domain of dinoflagellate luciferase . Luciferase is involved in catalysing the light emitting reaction in bioluminescence. The structure of this domain has been solved [1]. The core part of the domain is a 10 stranded beta barrel that is structurally similar to lipocalins and FABP [1].	25.00	25.00	46.90	46.40	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.82	0.70	-5.25	3	71	2009-01-15 18:05:59	2007-08-09 16:40:55	4	4	18	1	0	69	0	174.50	64	66.51	CHANGED	PLCKDPYGPEVpuLVEsLL+EApDD+TLCF-NFpcPCPQLTKEQVAhCKGFDYGDKTLKLPCGPLPWPAGLPEPGYVPKTNPLHGRWITVSGGQAAFIKEAIKSGMLGAAEAHKIMADTDHHQTGGMYLRINQaGDVCTVDASVAKFARAKRTWKSGHYFYEPLVSGGNLLGVWVLPEEYRKIGFFWEMESG+CFRIERRAFpsGPYMFLRQATEVAGKISFVFYVKVSNDPGSKPIPLQSRDYTALAGpDNVPDNLGKPYsCTAKDLDYPpKRDuWLDpNKcpMLcQR-lVuoAF	...........PLCtDPautElpslspsLLp-AppD+TLsasNFpDPCPpLTKcQVt........sKthpLPCGsLPWPAGhP.PsYVPKTsPLpGRWITlSGGQttFIKpuIcsGMLGtuEApKIhADTDHcpTGGMaLRINQhG-.CTVDASVAKaARAKRTW+SGHYFYEPLVsGup..GVhsl.EEY+pIG...................................................................................................................	0	0	0	0
+10119	PF10287	DUF2401		Putative TOS1-like glycosyl hydrolase (DUF2401)	Wood V, Coggill PC, Bateman A	anon	Pfam-B_11571 (release 21.0)	Domain	This family of proteins is conserved in fungi. One member is annotated putatively as OPEL, a house-keeping protein, but this could not be confirmed. It contains 5 highly conserved cysteines two of which form a characteristic CGC sequence motif. It has recently been shown that this family is related to known glycosyl hydrolases [1].	21.50	21.50	22.70	21.60	21.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.70	0.70	-4.88	39	173	2012-10-02 19:29:29	2007-08-10 10:30:32	4	7	100	0	120	172	22	219.60	41	50.78	CHANGED	uusWsRsuYY...osuou-NlTFLNptGu.tuSGsaSssaGsSLSYAsocGsuuASSspsLs.-sh.............lsSspEasIaSsppCsss....sCGaYRpG.IPA.....YHGFuGssKhFlFEFpMPs.sssssu..hshDMPAIWLLNA+IPRThQY....ssssCSCWp....oGCGEhDlFElLsuusc...+LhSplHshQG.ss....ssGuGsssYFpRPTs..uohKuuVlFsusss....lplltl.s-shsFssolsussVpsWl	..................................................usWsRhuYY.ps.ssuos-NloFLNptGu..ttSGsho.sshGsuLS.YA..suDG..s...uuAuospsLs.ssh................lsSspEahIhSsppCsss.....sC.GaaRtG.hsA.....YHGFsGssKhFlFEFpMPp.spssou.........hs.DMPAIWlLNA+IPRThQY....spss..CSCWt........oGCGEhDlFElL....sussp...+hhSphHshQ........thusGspsYFpRPos..uohK.suVlFsusss.....lplltl.s-sh.sFs.s.olssssVsph...........................................	0	25	66	105
+10120	PF10288	DUF2392		Protein of unknown function (DUF2392)	Wood V, Coggill PC	anon	Pfam-B_10085 (release 21.0)	Family	This is a family of proteins conserved from plants to humans. The function is not known.  It carries a characteristic GRG sequence motif.	27.30	27.30	28.40	28.00	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.22	0.72	-3.71	35	268	2009-01-15 18:05:59	2007-08-10 11:46:09	4	8	242	0	195	274	0	104.40	28	23.31	CHANGED	LAsclLutlsKGRGuulshpls.sssp......tclphlhPLRDlltpElphYsphttls.h.hs...hhhp................tpphscshoIpcLsppalpsLpps.aPSssSTVlRTusKL	....................LAhchlstlshGRGttlshp.....ss.sspp.......................tslhllhPlRDhhtpElshYsp.ht.s..l...phhhs....hh.t....................................................psscstSIpcLhppalpslppp.aPusluTVhRTusKL....................	0	57	100	160
+10122	PF10290	DUF2403		Glycine-rich protein domain (DUF2403)	Wood V, Coggill P	anon	Pfam-B_11570 (release 21.0)	Family	This domain is found in the N-terminal region of members of DUF2401 Pfam:PF10287. The function of this glycine-rich region is unknown.	20.90	20.90	21.70	22.20	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.13	0.72	-3.82	26	164	2009-01-15 18:05:59	2007-08-10 15:40:59	4	7	97	0	113	155	1	64.50	42	14.41	CHANGED	scplpas....NVG..aSGoYpsVopMspto....C...sC..spsshpFSGslAPlsEcLSVHFRGPLpLpQFAVYhPs	......................ptl.Ys....NlG..hoGoYpcVosMppts........s.....sC...sppshsa..SGsluPLsE......E..LSlHFRGPlpLhpFusYhs............	0	23	62	99
+10123	PF10291	muHD	SAFF;	Muniscin C-terminal mu homology domain	Yang H, Coggill P	anon	Yang H, Pfam-B_7632 (release 21.0)	Domain	The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.	25.00	25.00	25.10	25.40	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.99	0.70	-5.20	32	429	2012-10-02 01:13:52	2007-08-10 17:13:25	4	5	231	1	244	384	2	258.90	34	33.14	CHANGED	.GLsASlsEslsAhF+sGtlsc.............splsGElALsYsus.sss.......s..........tshslRlsNhpplEKVhsNppal..........pppss.......sc...aplshstlsspo.hsu.............hKYpl+hp.......s.sPlhlpssW+hEsppsulhlpYphNs....uhsss.....lsLpNlslsVsl-su..............psTus.o.cPp..usas+EppplsW+hs-.lslssps...t+LlARF.ssssss.........p.usVps+Fphc.ssshpt.......lslshh..............t...P....................s..ap.s.spRplsuG.p..............Yhup	..........................................................hslssuhsEsVsAaF+susso+.............l+ls..GEhsloFPuuhsphhss............sP...........ssLsFR.l.........p.Nhu.p..LE+..lhPNspLlhp........sspss...............sp..........Fhl.NhssLtst.LppsuptpPtu.................................aaNlshLKYQlp....sps................pssPLpLsshW+s.csspTslpl-Y+hNsp......uhsss...............ssLpNlpllVsl..-Gu...............sTshp.u.hPs...AsW..stEpp+lhW+ls................-...lo.pucst....GpLh...ARFphspuss..........pPusl..s....spFssc.....u...so..LSG.........hclpLs......................................................Gssa+h..s.hl+++hssG...+Yhu.s............................................................................................	0	56	99	180
+10124	PF10292	7TM_GPCR_Srab	Srab; 	Serpentine type 7TM GPCR receptor class ab chemoreceptor	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2]. The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organisms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells [3].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.13	0.70	-5.74	17	186	2012-10-03 04:04:29	2007-08-10 17:28:29	4	4	10	0	183	384	0	249.20	17	86.59	CHANGED	ppsCphMtpluoStaL+hoLhhpLllsllulPlhlhu...laphppspLFHhNh+lIhphHhhuhhlHshuRlhLHuhDLaNYhs....hssC-hhPshhRChllRhhYshGhalsssTslsLlIERhlAThpuspYEpptphhGlllshhQlsluhhhhhhhapphsF....sshh.YChshpsu...sh.hplshhlslhsQlluhlhFtaLh+hNc+lRs..tphpuoLSsRYQLEQNlpShpsL+hFushshlFlhhphhhhhhlhhhutphppspYhAllElstshPlYullhhhhlh+p.+c.+schppsLpsphphstsp...YF-papc...pls	..............................................................................................................................h..hhhs.hh.s.h....h.hh....hh......t.h.h..H.N.hphl.h..hhhh......h....h.lh..sh.................h....h...h...............h........h.h....hh.............p.s.p.h.h........t..h...............hC..........h.hhRh.h.hu..........h.h.h.......s.......th.o...hh..h..l.....h.....lERh..............lAThh...pp.Y..E................p.p.t..t....h.h...G...h.hl................s.h...............hp..hh.l.uh.h.h.h.h...h.hh..t...t.h.............t.hh...a....C....h.....................t..s..........h.....h....hh..h.h..h..hh.p..l.hs.h...h.h..h.........h.........h..l.h....t.h.N.p..................p....h....p....................t...sLop........+......aQ......lppNh..............p.shp.h.l...h........h.h..hp......h..hhh..h.....hh...h.h.h..h........h........................................h......................................................s...........h...h..................h.........................................................................................................................................................................................	0	64	90	183
+10125	PF10293	DUF2405		Domain of unknown function (DUF2405)	Wood V, Coggill PC	anon	Pfam-B_12420 (release 21.0)	Family	This is a conserved region of a family of proteins conserved in fungi. The function is unknown.	20.20	20.20	20.30	20.20	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.75	0.71	-4.49	32	202	2009-01-15 18:05:59	2007-08-13 10:57:13	4	25	165	0	156	211	0	159.50	26	6.23	CHANGED	hpschlRlhscuPplcp..hWsRllslpsh+lshc..phcpp....................lslps-sl+lslPHpalhaplhDNlssshKulKQLptph+s.....sssch....lhs+p..pstplP+lsl+octlhaplEDDPFEpcLuhIYclGllEQ+pRLp+.ptFct+spclppsspppt	........................................................................................................h...p.hRhhstsPthpt...hW..scllslpshclshc.tptpts.............................t.hslss-sl+ltlPachhha.clhDN.hlshhKulKpLhapaKs........ss.ch.......lhspt..tPptlP.clsl+s+phhh-lEDDsFEh+LuhIYclGl.EQ+pRLtR.ptFctKlpclpptp...p..........	1	42	83	139
+10126	PF10294	Methyltransf_16		Putative methyltransferase	Wood V, Bateman A	anon	Pfam-B_19672 (Release 21.0)	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.08	0.71	-4.81	15	2584	2012-10-10 17:06:42	2007-08-13 15:02:31	4	72	442	2	1819	5419	1399	156.00	21	50.49	CHANGED	hhcss.LpIpE-sus.ulutplWDAulshshYLtpt..tt............tspphsshslLELGSGsGlVGlulAth....h.ssssVhlTDl--.hh-lhcpNIpl..t...hlssclpscsLcWG-.cL.s-hhssp.hDLILsADClYhEcuhssLlpoLpcLssssss..lLhuaK+R.....+cu-ppFFphlcct	......................................................................ht...........................h...G.h.h.l.W.s....uuh.....hL....u...p.......a.l.p................................................................t.t....h.psp.p.l.l.EL.....G..uG.s.G......L..s..u.ls.suhh.................................ss.p.V..h...h.T..D.......h....s...p........h.....l..p....................l...p...t..........N.l....ph...N....t............................t...s....p.......l.......p............s........t...............t....L..........p.......W............s.......p............................h...............................................p...............h..............................t..............................t...........................h..........D.............l...........l..........l...u...u....D....s....l...........Y.....................p.......h.....h.............Lh...p...s...l...p...t.h...h......t.........t.t..................h.hh.s.........t........................................t........................................................................................	1	693	1089	1500
+10127	PF10295	DUF2406		Uncharacterised protein (DUF2406)	Wood V, Coggill PC	anon	Pfam-B_13850 (release 21.0)	Family	This is a family of small proteins conserved in fungi. The function is not known.	21.10	21.10	22.90	53.60	17.60	16.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.61	0.72	-3.46	18	139	2009-01-15 18:05:59	2007-08-14 10:52:48	4	1	105	0	94	127	0	69.80	52	25.28	CHANGED	AlpEAQPappAh.......htpppstphpstpc............+DhaGpsIs................................................pPDhSNPTRsR.ERPLDTIRuFEhAIsG	.......................................AlpEAQPh.ppAh..................pppht.hps.p+..................+DhaGpsI..s................................................pPDlSNPTRsR.ERPLDTIRuFEhAIsG...	0	13	43	76
+10128	PF10296	DUF2404		Putative integral membrane protein conserved region (DUF2404)	Wood V, Coggill PC	anon	Pfam-B_12178 (release 21.0)	Family	This domain is conserved from plants to humans. The function is not known.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.82	0.72	-3.85	32	588	2009-01-15 18:05:59	2007-08-14 14:30:48	4	15	262	0	414	579	1	90.30	24	12.53	CHANGED	NAllGRlFhshh+opthpshltpKIpKKLs+l+...pPsFl.scltlpclDhGsssPhlosspl.plsscGphhhs.............hslpYpG.......shplplpTphsl	............................Nslluphhhphhpss.h.h.....ps....hlppplpcpLs.clp.....hPsal..sclpls-lshGsssPhl..pss.c.l...h..t....l......s........t....p.G........hhhc...............................h-lpYsG.......shplslpophp...........................................	0	130	232	350
+10129	PF10297	Hap4_Hap_bind		Minimal binding motif of Hap4 for binding to Hap2/3/5   	Wood V, Coggill P	anon	Manual 	Motif	In Saccharomyces cerevisiae, the haem-activated protein complex Hap2/3/4/5 plays a major role in the transcription of genes involved in respiration [3]. Hap4_Hap_bind is the essential domain of Hap4 which allows it to associate with Hap2, Hap3 and Hap5 to form the Hap complex [2].	21.10	21.10	21.50	21.80	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.05	0.73	-6.22	0.73	-3.92	11	175	2009-09-10 17:07:33	2007-08-14 17:00:41	4	3	128	0	121	171	0	16.90	77	3.20	CHANGED	sSKcWVLPPRPKPGRKP	...TSK-WVlPPRPKPGRKP...	0	29	67	104
+10130	PF10298	WhiA_N		WhiA N-terminal LAGLIDADG-like domain	Mistry J, Bateman A	anon	Manual	Domain	This domain is found at the N terminal of sporulation factor WhiA. This domain is related to the LAGLIDADG Homing endonuclease domain while the C terminal domain of WhiA is predicted to be a DNA binding helix-turn-helix domain [2].	23.40	23.40	23.40	23.40	23.10	23.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.47	0.72	-4.14	74	1805	2012-10-03 01:41:40	2007-08-14 17:02:56	4	4	1794	3	299	986	93	85.90	33	27.65	CHANGED	pssppA...ELuAllRhsGuLpls..spp.lslclpT-ssulARRlapLl+cha.slpsElhVppptpL+K.sshYlVpltps..spplLccl.sll	................t..pt+AELuAllRhsGuLsls.....sp.......p....lslslpTENuslARRlaphlcchY..slpsElhV+p.+hp.L+K..NshYl.VRlspp....spclLp-Ltlh.............	0	110	208	263
+10132	PF10300	DUF3808	Deme6; IML2;	Protein of unknown function (DUF3808)	Wood V, Coggill PC	anon	Pfam-B_15386 (release 21.0)	Family	This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain Pfam:PF07719 at their C-terminus.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.47	0.70	-5.93	20	568	2012-10-11 20:01:01	2007-08-15 15:32:33	4	21	235	0	370	612	25	413.60	24	75.08	CHANGED	hpAlsLhLsschp-AhshLc...h...sspShaH.uLGtusltalpAhlTFEscchppAsssL+cAppssp+.Rc+uphhs.............t..h....phht..thctplCYAEshLh+AsLsF.hsEshlshIKGuhKlR+uYphYc-hhphhpth....................................................................................................shtps.........psccalcuGVphGhGlFpLhlSLlPspll+LLphlGFpGsR-hGLptLhc.uup.scsl+usLusLsLLhYashlp.hhuh.............................tphshccs-plLt.hpppaPpuulaLFacuRlptlpGpl-pAlphhcpsh..tsppchKQl+pLChaElhashsappcacpAhphhhhLhcpScWS+AhYsYhpushhshhscp............-ttstt.-ptsplhcplssLtt+hth..KslPhE+FshRKsp+apup..p............shhssPshEhhYhWNGashhuccth..puhhphh.p...............p.pp........D-ps.....lhpLL+GlsL+pL	...............................................................................................................................................uhthhhssphptu.thhp................................tpps.............hh...s........hshuhl.hhp.Ahh.sF..-..................pphp..Ahpthpps...phst.t..pcpsphhp.....................................t...h.......tth.h.....t.hchplshA-s.l.p.Ahlsh...pps..h..hthlKuhhplRpuathh..p..p..hhp.lpt............................................................................................................................................................................................................................p...hhcuGlphshGhhpLhlShl.Psplh+llphlGFp.G...........s+phGLp.L.....h.....p...u...............s...............p..tpsh+usls.slhLLh..aashh..hhsh.........................................................................................thshptscplL...t.hhttaP......p.us...la...hh.puRhthhcsp....lp...pAlphhp.psh.....p.........................p.p......p......h+................Q..........h..p..t...ls.h.a.E.hhhs..hh.hpapt...A...h...h.....h.Lh.p....s.p.W..S..+.......u.hYhYh......tu.shh..hhc.........................................................cph.plhp.ps............ssh........h.......t.+hth........+sh.Ph-pFsh.+Ksp........+a.tpt..............................hhh..shhEhhYhWsuhthhstp.......shh.h............................................................................Dp.s..........lh.lLhuhhh+..................................................................................................	0	129	181	279
+10134	PF10302	DUF2407		DUF2407 ubiquitin-like domain	Wood V, Coggill PC, Bateman A	anon	Pfam-B_17915 (release 21.0)	Domain	This is a family of proteins found in fungi. The function is not known. This domain is related to the ubiquitin domain.	25.40	25.40	25.40	25.50	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.50	0.72	-3.80	46	152	2012-10-03 10:59:06	2007-08-15 16:09:52	4	4	135	0	111	189	0	115.20	28	33.54	CHANGED	hhlsIRFos......slPD...l.LsIs....s.ss.sTsstLKp...........................................hIRpcl..........sp.......hss+RLRLIa.......sG+h.Ls.-ssslssplphs........................................................ptpupts.p.................+h.YlHCslG-.	...................h.hlsIRFos......ulPD...l.LsIs......sssp..sTsttLKp...........................................hIRppl.......................................s.p.......ssp+RLRLIa.......sG+l.Ls.Dsoslusplph.....................................................................t..p.ptpupss.t....................................phYlHCslG-.................................................................................................................	0	27	58	92
+10135	PF10303	DUF2408		Protein of unknown function (DUF2408)	Wood V, Coggill PC	anon	Pfam-B_16841 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is unknown.	25.00	25.00	45.80	25.00	24.10	24.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.89	0.71	-4.04	22	259	2009-01-15 18:05:59	2007-08-15 16:25:05	4	4	128	0	202	255	0	114.90	31	47.36	CHANGED	plcplss-LtshapcLlsIRRslhshsopsKhs.....................................ssclppLpppLccl-spR..hDG...cFhus-.....sphlps.QsllsGLLDcChphhpDl.tccs......................pls.phpshYcpLl-I+sp.LEpLhlT+RWTLRE	................................s..-.lotsL.PlappL.ol+RsLhplpppuths.......................................................................spELhshphcLppIDshR....sDG.............KFhsss.............tph..t.QuhlssLLscCaclsp-lptptt....................................................................................................	0	58	117	174
+10136	PF10304	DUF2411		Domain of unknown function (DUF2411)	Wood V, Coggill PC	anon	Pfam-B_15078 (release 21.0)	Domain	This is a 38 residue domain that is found in proteins at the extreme C-terminal end of some HEAT repeats Pfam: PF02985. the function of this domain is not known.	20.10	20.10	20.10	20.10	20.00	19.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.46	0.72	-4.31	21	177	2009-01-15 18:05:59	2007-08-15 16:51:16	4	5	166	0	127	191	0	35.70	31	3.74	CHANGED	pslpclhcsLcaVtppDs.DslV+tpspssL-pL-sh	..........l.clh+lL+aVtsp-s..Dsll+tHAphsLEpL-s....	0	28	59	100
+10137	PF10305	Fmp27_SW		RNA pol II promoter Fmp27 protein domain	Wood V, Coggill PC	anon	Pfam-B_15444 (release 21.0)	Domain	Fmp27_SW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic SW and GKG sequence motifs.	25.00	25.00	26.00	27.30	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.00	0.72	-3.59	31	159	2009-01-15 18:05:59	2007-08-15 16:57:59	4	12	125	0	123	169	0	102.10	32	3.74	CHANGED	pAhp+LpcphSpSWlp+lcthcphpppphpchpphhaGtcp.htpshs.scsllshsppPsLhshlhc-lDlsls+PpFslcclscFlachGKGhP+spcYSlL	....Ahp+Lpcp.upSWhcRlcpthphppsphcchp..........ph.............hhGssc...sspshp....p..sc..pll..sh.sppPsLhshllp-lclslsKP.S.Fslcc..lPcFlHclGKGhPcDhcYoLL..	0	30	68	110
+10138	PF10306	FLILHELTA		Hypothetical protein FLILHELTA	Wood V, Coggill PC	anon	Pfam-B_18082 (release 21.0)	Family	This is a family of conserved proteins found in fungi. It contains a characteristic FL(I)LHE(L)TA sequence motif, where the bracketed residues are I, L or V. The function is not known.	25.00	25.00	32.00	30.70	24.20	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.02	0.72	-3.94	17	117	2009-01-15 18:05:59	2007-08-15 17:09:20	4	3	115	0	85	112	0	89.50	34	37.06	CHANGED	+lLpRl...P+Fh+.asp.hhsuPhoalsSFLILHElTAIlPLhulWahFap..........................hshhs.htlPsa.......hlscuh............chhcchhp+h.Gathhstpc	.................l.sRL...P+Fh+.Ysp.hhsuPl.oalsSFLILHElTAIlPLhuLahhFHh..........................................hsh...hs...hhlssh........hlscGs....................cpht+hhc+h..Gaht.t...ht.....................................	0	19	46	71
+10139	PF10307	DUF2410		Hypothetical protein (DUF2410)	Wood V, Coggill PC	anon	Pfam-B_19378 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known.There are two characteristic sequence motifs, GGWW and TGR.	22.10	22.10	26.30	22.30	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.30	0.71	-4.94	20	120	2009-09-10 23:56:53	2007-08-15 17:10:28	4	1	115	0	88	119	6	193.30	40	37.24	CHANGED	pSPLPNPpLWsusTIGhLpu.-sFuN.GGWWaDsclLuA..TG-GhthEcs+AWcGWWNEcIVcLlcLShcpKD..uLoVLLTGRuEssFucLIcRh....lcS+pLs...............FDhlCLKPp.sstspcasoThcFKpsFLc-Ll.pTYp.ps-EIRIYEDRl+HlKuFRcFFcphscp.........sRpslss-VIpVs-tspYLsPlsEsApVpchINsHNtsl	.............oPhPN...spLWsssslG.h.Lps.pshss.G.G..WWpDsphLuA.....ospuh.ch.c.cs+u.......hcu.............WWN-pIVpLl.chShppKD..........sLo........V...LLTGRsEssFsclIc+h..........lpS+tLp...............FDhlsLKPphs.....................tspcapoTMcFKQpFLccLl.pTYc..pucEI+lYEDRl+Hl+uFRcFFpphNpp...............sR.tsl.su-VIpVs-hsphL.sPlhEhApVpcMIspHNtth................................	0	21	45	73
+10141	PF10309	DUF2414		Protein of unknown function (DUF2414)	Wood V, Coggill PC	anon	Pfam-B_22455 (release 21.0)	Family	This is a family of proteins conserved from fungi to mammals. One mouse member is referred to as ELG protein but this is not a homologue of human ELG protein.  The function is not known.	28.90	28.90	28.90	29.00	28.50	28.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.98	0.72	-4.29	19	181	2009-01-15 18:05:59	2007-08-16 10:01:07	4	6	164	0	138	181	0	61.80	39	12.76	CHANGED	tplR.Esl+lpGVDshST-DlKsahstY............................hs.p.ss+IEWIDDoSsNllatopcsutpALhsl	...................plp.-plalpG..V..Dc....hoTpDlhsYhp-a.................................s.Ps.+IEWIDDoSsNlVatsptsAtcALhs...........	0	41	69	108
+10142	PF10310	DUF2413		Protein of unknown function (DUF2413)	Wood V, Coggill PC	anon	Pfam-B_20450 (release 21.0)	Family	This is a family of proteins conserved in fungi.  The function is not known.	23.90	23.90	24.20	25.30	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.80	0.70	-5.67	21	142	2009-01-15 18:05:59	2007-08-16 10:03:45	4	2	132	0	109	146	0	405.10	31	92.26	CHANGED	lL-hlDsLssspsssp...............stpspsss....sssps--DlLp.L--Ltppth.ppsp.....t................sp+pscsss........ssssssppppstscKsscospstpstshsssspsppp......tttsph.sshuShuuhWs..........WGshhusAp.h.psshcpAptsspcIpp...Ecsphhscplps.s.....stltsl.su...................cLt...hsTho....slhpslA.sl...socEhLpIHlsHDL..lsYsuL-.llhssFs+VMu.QVEGG....lhIthsp.sp......................t..tt..hp..ssss.+slshhpGhl.-GpKLs+ANhEshhccahpu+tsscpttcpupt..p......................-sssl+sSDIFluIQAlsh..........tustsp...t...s...h.hcsssssphsFslhL+D.spsIshpThSQuhPt+WhcWLDupt...............................tt.t-..-stslDPpEWVpEWlE-uLuLulGllAQcYVh+RMGl	....................ht.h-sLs.spsssp.................................tstsss...........ststs-pDlLs.L-p.Ltppp...p..st..........ts...........stppspsss....................ssstsp.p.ppt.s.tsp+sscssps.pttp...sspppsppt..........................tt.t.pshs.u....suuhW...............W.G.uh.huoAo.........tshcp..Apss...hpclpp.......Epspphscplpt.h.............s.lpsL.us..........................cLpt.s....hsThT....sllcslAPPI........uoHEhLpIHlsHDl..hsYsuL-sllassFs+VMu.QVEGGt...lslppspput.........................t..sts.hc..pssp.RslshhpGhs.-GpKLspAshEshspcahsscsshcptt.ppupp..s.......................csssl+pSDlFluIQsls.............ttssttp....t.ttsh....ht.pppspppls.FslhLpDshHsIsatThSQuhPt+WhcWL-uss...............................tt.tp..-ssslDP+EWVt..EWlE-sLsLulGllAQcYVs+RMGl.......................	0	30	62	93
+10143	PF10311	Ilm1		Increased loss of mitochondrial DNA protein 1	Wood V, Coggill PC	anon	Pfam-B_22448 (release 21.0)	Family	This is a family of proteins of approximately 200 residues that are conserved in fungi. Ilm1 is part of the peroxisome, a complex that is the sole site of beta-oxidation in Saccharomyces cerevisiae and known to be required for optimal growth in the presence of fatty acid. Ilm1 may participate in the control of the C16/C18 ratio since it interacts strongly with Mga2p, a transcription factor that controls expression of Ole1, the sole fatty acyl desaturase in S. cerevisiae responsible for conversion of the saturated fatty acids stearate (C18) and palmitate (C16) to oleate and palmitoleate, respectively [1].	25.00	25.00	25.80	25.00	23.40	24.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.04	0.71	-4.74	22	113	2009-01-15 18:05:59	2007-08-16 13:16:10	4	2	109	0	85	103	0	171.60	30	86.20	CHANGED	LSu+ollhu+shFLhsLAaahl+sPpslspsshVhlLGpuMpLsh..h.....hsp.pu.huhhulLhsh.AlsDLIsLht....sph....paapohsP.............................hRlhhaFhlssasYhspssh....................................................lpNplVFTYuFhEhhh.FhlassLR-ERpchhp+hs	..........lSopollhh+slFhhsLAhahhpsPpslsppshlhllupuMplPt..hp....hsp...sushuhhullhhhhulsDLlslhp....sph.....paapo.sP..........................................................................................lRhhlaFhlohhsYhhpssh...........................................................................l+NplVFsYsFhEhhh.FhlassLR-E+pp.hp+..h......................................	0	14	41	70
+10144	PF10312	Cactin_mid		Conserved mid region of cactin	Wood V, Coggill PC	anon	Pfam-B_20647 (release 21.0)	Family	This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus Pfam:PF09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localisation signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo [1].	22.50	22.50	24.00	29.20	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.34	0.71	-5.04	22	283	2009-01-15 18:05:59	2007-08-16 13:39:26	4	9	220	0	208	282	5	178.40	35	31.47	CHANGED	p+tppstphccW.tcE-pFhLcQu+t+ucIRl+-sRuKPIDhLshtlchhp.................................pcsh-hph.h-P..slhpGL.shc-Lc-Ltp-Ichahp.LEpspt.ph-.aWpshhhlsccclpphcp.ptsts+uh..................ssVssDlpcllpsKohppLppLEtpIcpKlpSsps..lDhsYW.....EplL+pLpla..........KA+ApL+chap	...........................p.p-stphcpW.tpE-pFhL..cQAKh+ucIRl+-GRAKPIDhLuhhlph....................................p....................psshp.l-h...t-Ph..shhpGL.....ohp.....-hc-LhcDIcs.ahp...LEp.s...........p....Nh.............-.aWcshpslscDclp+hcp.htsps+uh...............................htsoVssDl..pplh..ps.KohppLpsL.ptpIctKlposps..........lDhsYW.....EpLLppLpsa...........hA+A+L+cha........................................................	0	77	118	171
+10145	PF10313	DUF2415		Uncharacterised protein domain (DUF2415)	Wood V, Coggill PC	anon	Pfam-B_25751 (release 21.0)	Family	This is a short, 30 residue domain, from a family of proteins conserved in fungi. The function is unknown. There is a characteristic DLL sequence motif.	20.10	20.10	20.10	20.30	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-7.96	0.72	-4.28	15	152	2012-10-05 17:30:43	2007-08-16 14:57:37	4	4	138	0	111	166	0	41.20	42	6.54	CHANGED	GAFRssKFS.tsshp...DLLllSEHpGRVHllDLRp....shps+QVIs	.GAlRshpFS..tsh........DLLsasEcpGRltlsDhRp....sFsp+Qll.........	0	29	64	97
+10147	PF10315	DUF2416		Protein of unknown function (DUF2416)	Wood V, Coggill PC	anon	Pfam-B_28778 (release 21.0)	Family	This is a family of conserved proteins found in fungi. The function is not known.	26.70	26.70	26.80	27.40	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.41	0.72	-3.80	12	63	2009-01-15 18:05:59	2007-08-16 16:18:41	4	1	62	\N	44	55	0	118.50	32	77.50	CHANGED	sthspoPhPuhhhuusL...lt+s.hssps.....................shhtPoptoshhFGuAphLGuahIYDGDlpNGuGFshAWSsLYLlVsG+sSlpulhhG+lhPLsLoslAluNAslYG++Fh	.................................................................s.....sP.st..h.s.....h..ps.h.tpps...........................shhtPoptoshhFusspulGuYhlaDGDhpNGuGFssAWSsLYLlVsG..+pShpul.h....hG+..hhPLsLoshuhsNuhlYGpcFh....................................	0	14	25	38
+10148	PF10316	7TM_GPCR_Srbc	Srbc; 	Serpentine type 7TM GPCR chemoreceptor Srbc 	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-11.88	0.70	-5.14	62	285	2012-10-03 04:04:29	2007-08-16 17:46:55	4	8	7	0	280	476	0	218.40	23	87.25	CHANGED	M.hhh.hhsshlullhuhhshhlNlalLhpIh.....ppKs-hhLFYaRFhlDlhauhslshahsahllh.........ph.schh...h+sllhalshsspslushRuhlslhIolERllAsahPIhY+saRpplPshhIhllhlshulh-phlLFsaCshsl.slPhsCsshtCulNpCahpYWthpcpllashhhhhSllLsh+La..lasp......tppsspplS+..As+lALlDuhhlhlFshlPshhsshh....hhshpshGPhsslhKhhGssIEulllh+lLh+cp	.................................................................................h.h..hshh.s.hshhhshh..hl.h............hh........pp.ph...Lh.h.h...+h....h.h.Dhh..h.u...............h..........h...h...hhhh.hh.............................h....s.p.h.....p...h...hh..h....h...shsh......hh.t..h..Rs..h.......l.sh..hI.sh-Rhh................AsahPlhapp...h.+..p.h..h....ss....h.h..l...h.h.h..h..h.h.hshh......-thlh..a.h....h..Cshth.phs.....s.CsshtChhsp..C..ah.pY..a.hh...c.l.h.hh..hh.....hhhoh.hlh..h+Lh......hhpt................t.tt...tspp........hp+...............ANp...lulhDshhhhhFshlPshhhs.h........................h.hp.hGPh.sh.+.hGhhlEuhlh...h.................................................................	0	91	105	280
+10149	PF10317	7TM_GPCR_Srd	Srd; 	Serpentine type 7TM GPCR chemoreceptor Srd	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.76	0.70	-5.43	59	467	2012-10-03 04:04:29	2007-08-16 17:47:12	4	12	7	0	462	1891	0	209.10	18	81.09	CHANGED	hplaaslhhlhulhhphhLlaLIlh+SP+tlcshphlLhspshsphhtshhshhsQ...........hRhl..sspholshlshG.C+ah.ushhCahsaphhhpshhtushslllohhaRYhhLpphp...pppphhhhhhlhYhhslhh.............lhhhhs.sst.tlpthpphhaPsY...shs.h.s.......lsGhhshpshsshhshhhhslsshhlslhhhhhR+KllphLpp..s.phSpso+shp+pLlpuLThQshlPhhhal.shhhahhsphshhph.hhpahlhshsslssllsPllolYFlsPYRptlhc	.............................................................................................................................................................................................................h....s....p.hhhhhhh...........p.s..ht........ht....h....hl.h...........s..h.......p.h.h.......h....s..h.h...............................R..l.............t.........h..h.h..h............G...s......p..h.......h........t................................h...s....h...............h...........................h................................................h.........s....h........h.......h.s.h..hh...+..h......h......h........................................t..........................h......h......h...........h......h..h....h...h................h....................................................hh..........h.h................................................h...........................................h.........p.h..........t.h..p......................................h..G..............................p....h...................t.............................................................h................h......h..........h....h....h..h..............h............h.........h......h...........h..h..h.....h.....p...t....t....h........h..t..h...l.........................h...s...t..ptt....tpph..........h...............h..............sLsh.Q...........s...h...l.......P..h..h.h.h.h..............hh..........a...h.......h.........................h........t....h.h....p...................h................p...hh.....h.................................h........s...hhsP...hh.hhh...l....sY+p.h...................................................................................	1	204	272	462
+10150	PF10318	7TM_GPCR_Srh	Srh; 	Serpentine type 7TM GPCR chemoreceptor Srh	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srh is part of the Str superfamily of chemoreceptors [2]. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.97	0.70	-5.61	186	1040	2012-10-03 04:04:29	2007-08-16 17:49:53	4	23	6	0	1028	2479	1	244.00	20	84.56	CHANGED	sSsphhshshHllshlslPlalaGhYsIlhKTPppMcsVKhsLlshHhasshhDlhlohlshPalhhPshuGaslGllphh.ulss.lQh....alhhshhs............hhssSllhlFENRa.h.lh.spt...hph+ph..Rhhahhhpahhs.hhhhhPshh.pl.....P.-Qppu+hhhhcph...P.C.....hspphhpt.sshallsh.-.t...hh.h..hshshhhhhhhhpllhFhhhhhhhlhpp.p....p.sh.SppThchQ+pFhhulhlQhslPhlllhlPhhhhhhshhhs..aas.QshsNls.hlhhuhHGlhSTlshlhlH+PYRchhhphhtt	...................................................................................................................................................................h....h..h...h.h....t.hPh....h...h.s....h..ah.l....h....h....p.o....s........hp.p.h+h.hh.........h.........p...h...h...s...h...h...h...-...............h....h.....h.......s...h...............h..h......h.........P..h................h..h..............h....P......h....h..u...h....h......s......h.....G..h....h.....t.............h......t.....h.......s...........h.......h................h...h...h...h...h....h...h..h................................h.h.s...hu....h.......h.....h....h.....F.....-....s..Rh....h......l.h..t..............h.h.phh........+h....h....h....h......h...........h...h...h.....s.....h....h......h.....h...h..s..h..h...h.......h........................s.......p...Q......p..........t....c................h..........h....p...h.h.......................P..s..............................s.............h...h...p............t...h...h.l....h..s....s.h.......................hh..h......hhh.h...h.h....h..h.h...h................h...h......p...h...h...h..h.......h.h...h......h...h.....h........h..h.t.t.................ph..S..t..pT..h....p.....h..Q.+..............p.h........hh.u..l...h...............hQ...h..............h......l............sh.h.....h.h.hh.Phh..h.........h.h....h....s........h....h...ht..................hhs....p.......h..............h...s....s........h.....h...h..........hhh....s...hH.Gh...h...u...o.....lhh.lhhppsYRphhhphh..h.......................................................	0	287	375	1028
+10151	PF10319	7TM_GPCR_Srj	Srj; 	Serpentine type 7TM GPCR chemoreceptor Srj	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily [2]. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	24.10	24.10	24.10	24.10	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.95	0.70	-5.31	35	202	2012-10-03 04:04:29	2007-08-16 17:50:14	4	9	6	0	199	1601	0	225.70	31	86.97	CHANGED	Ma.hsWhahalP+lFusLSFllNPlFlYLIhoEpps.phGNYRaLLlaFAlFNlhYSlssllVPlslaua+YsFhlalscGhFh...-poc..ls.ahlusRCuhlusSYAlLllHFlYRYLllassphhpchF.shhlhhShhhhlhahssWp.hlCahhhtus.Eh.RpYIRcsFpcpYssDShclshluuLYt-uSscshhRSWhuIhlhTslSshSlshallluhhIhpKLp..phssshSppTp+hQppLh+ALlVQTlIPIhlSF.PCllsWYuPlFslsLuphhNYhpllAlusFPFlDPlAIIhhLPsaRp+l	..............................................................................................................................................................................................h..ha.....hPh.h..h.h.h.u.h...hh....N....s....h.h....l.a.llhppp....p...hGpY+aLLh.......h..FuhFsh.h..h....Sh..hp......h.l....h.....P............h..................s..............h....h......s..........t.......s..h....................h..h...h......t.........G...................F.................t.....................h.t...h..h..h...s.........R................C.......s.h......lu.h...o.Y........u....l....L.........HF.la.....Ra...h.......s.............l..h........t..................s...p..h.h...t............t.....hh.............h..h..h.........h....h.............hh.......hh...h...h..a.h..h......hW..h...............h..s......h..h....h......h...s................s.........E.....h..+...........p....Y................l................p.................t............s..F...c........a.....s.......s...s......p.......h................s...h....l......h....s...h........a...............................t..........s......o.............t.........h..........h...........p.............o...........h.......h.....u..............h......h.....h....h.....o........h.....h.....u......................h.................s.........h..........h......h......h...h..................h.............u....h......h..............I...h...t....p.l.............t.......t........t..h.....S..t.p...o....p..hp...h...pLh...puL.................hl................Q...........o...............h..........I...............Phh....h...S.a...P...s....h...h.....s....a....a.........s.............h.......h....t....l..p..h..............................h...h...h...........t...s....h.sl...uhF.s.h......h.DPlA..lhhhlPshRpt.......................................................................................	0	50	68	199
+10152	PF10320	7TM_GPCR_Srsx	Srsx; 	Serpentine type 7TM GPCR chemoreceptor Srsx	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.69	0.70	-5.23	23	428	2012-10-03 04:04:29	2007-08-16 17:50:27	4	13	56	0	362	23544	3	174.00	18	62.30	CHANGED	hllGlhGNhlhIhlhh+cKpL+S+sshL.slpClucllplsGplhhsh.hhh.thphspspCFhhlshhlauhshQuslhLhlslDhLIhVpFPhhY+plpppt..YlhhthhhPllaSshlhhhGalttss-..hllhCssPhALsspuh...phashSslhlslhllllYhhhhhl.....h+tpspp..............pssshp+lhKSLploVslalhuWhhsplsstlhlthststphtthlphasuhhlhluhopsaaVhhhpSsEYRpsa+pha	...................................................................................................................................................................h..hu.l.h.G..N...hh.h.l.h.h..h........h...p.....p.....................p..L...+.......p.............h...................h....h.............l.s...h.h....s......h.h.c....h....h.....h..............h.......s........p........h.....................h.......h.........h.....h............h..........t....................h.................t.............h...............t..................t........t..........C...........h......h................h............h...........h.........h............h........h.........h..........h....h............p.......u......s.......l......h...l.......h.......h...u...h..D..p.........h..l......u....l.....h........P....h...............p.........Y....t.......t......h.p...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	107	136	265
+10153	PF10321	7TM_GPCR_Srt	Srt; 	Serpentine type 7TM GPCR chemoreceptor Srt	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.30	20.30	20.30	20.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.02	0.70	-5.67	39	386	2012-10-03 04:04:29	2007-08-16 17:51:09	4	7	7	0	383	347	0	231.10	25	87.42	CHANGED	p.LhYs.hpuhsL....YsCs.....tp.hsps.GhpRPhhGhhhlshGlll......hLYlPshhslh+pc.h.phssYKlMlhLulhDhhulhlsSlhTGhLshhGssFCsYPphIalsGuluhusWhuuChssllLslsRss-ls.phhhphlFctphhahllhh.llYuhYhhhFTpPllFsopahuWFFDPhl..G+ssc.....hYhNhscshNNhllsssTshLYhhhshhlhtKht.s...sotthpKsppQIhhQusllChFpssuAhIYshMpFhtss.hllllGplsWphupGsssllYLThN+TIRpull+hlh..+sh+hpp	............................................................................................................................hhGh..hh.Ghhh................hh.Yh.hhh.h.h.h.p.p..p...h.....s..sa.........pl.M.hhL...................uh...........hDhh.s.hhh....s......s.......l...h..sGh.hh.h.......G...h....s....aCph.P.......h..h.h.hh.................G...hs...h............s...................W.hhsshhs..hhLhhp....Rh.h.pl..................hh.h.......t....t...hhh....h.............h.hhh..h...hYh....h.....hh...h.......h.....h......s..........s........h....h...a..s....s...th.....sa.......hh....s..Phh..........t....t...p.......................Y...sh.p....hh.N.N..h....hh...shhh.hhh..Yhhhh......hhl.h.h..p.............tt.....p...................h................p..h...............p.................l........hh.Qsh..hl.....Chh.ph........h..s.u...h.l..Y...sh..h.p.h.h.....s...s......h..hl.h.h.u..p..h..hWph..........spu.ssshlYlhhNpsl.Rpthhphhh........h...............................................................	0	132	152	383
+10154	PF10322	7TM_GPCR_Sru	Sru; 	Serpentine type 7TM GPCR chemoreceptor Sru	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Sru is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	24.70	24.70	25.00	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.16	0.70	-5.32	38	299	2012-10-03 04:04:29	2007-08-16 17:51:26	4	5	5	0	293	318	0	226.40	25	90.73	CHANGED	oIaGsppYhsapasahs..hs.sllAhlPhlYllPThhllh+Ihhhahpshhpps.p..lNhplFhlIhlsQlhshhFFlsDalhlRLPsTGlhTSWCAs.pPNcaLpllhhhshYh.sYsshlaPhLlsllRLlllhhPppa.pclsp+Ih.chulPhlalaPhhhohhhlPAlGhC+QlthPa.FGulhlhapsshauhpN..shh.hlhsohhahhhsllhNhlLahKLcph.p....phsspppsptspKAElSLTlToluMllsalsNshhslsalh.....shhsYhlhlRPFGNDh-ssllPWlFYLTHPlF+++pp	......................................l.....a.paphp.......hs..hhhhhshhh...shhhhhp.hh.hhh.....t...t.......hp..lF..........h.h.............................h.........shh...........h..hh.-ahhhR.l.....P..o...u........h....h.Ts..aC.....u.....p.........ts..p......h.....l.....hhh.....hhh.hh...h...tY.s....hhs...hl...hshhRlhhhh...............stp....................p..............h...........th........lh..hh..hs.......hhhhhs.hh.hsh.hh..s.uhChph..Pa..aG.ul.hlh........................t.......h................h.s................h.h.............shh..hh..hhhh..hhhhhhshhhhhKltphp....................t...pp..p.+uEho....lohThh....hlhsh..l.hs.....hhhh.....h..hh...................shh...a..h....h..hhRshh.DhphhhhshhFYhTHPhF+pp..h..............................................................	0	41	58	293
+10155	PF10323	7TM_GPCR_Srv	Srv; 	Serpentine type 7TM GPCR chemoreceptor Srv	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srv is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.64	0.70	-5.28	25	258	2012-10-03 04:04:29	2007-08-16 17:51:59	4	9	8	0	256	5739	1	205.70	17	78.89	CHANGED	aashsllolPlYlhllhsLlchRptshs.apTsFYplLlp+sIADlhshlsahhstsh.phshhcsFYaphQpaY.AuhhashhYhslhIRssGlshLohpRahsIshPp.phsphhpssphapllhlaWlsshllull...sLtssshtYcshcs..hshls-cshlppsohhAhlhlslsClhhllsYshLahhlR................ppops........ho+uhpREh+LshpVhlllhA.hshhsaahhpshhu.....pstsss..lFYhRhlYPlssGllSaINPaslLlhN+-lp+plhpplps	.....................................................................................................h.....h...........h....................hh...............................a.a....l...h...h..t.hhDl.h.............h.....h..........h..h...............................h..................h..........h......h...h.................t............h.....h.......s...............t.....h...........h.............h....h...h.......h.h...h..p.h.....h.....s....h...........h.....l.....s...h...p.....Rh..s.....lh..h.......P...........................h.....p............................h.h....p.t...........................h.....h.....h.....h.....h....h........a......h.............s....h......h......h....s....h................h.h..h.......s........p...............a.......tt.................h..h....h.....h............s.....................h........h...............t..................h.........................h.......h.......s........h........h......h....................h.........s.......h........h..........................h...............h.....h....h.h....h....h...h.p..........................................................................t..............p..t........t.p..E..h....p...L....h...h..........s.........h.....h....h.h............h.......h.........h......h........h......h......h.....h...h............h................................................t.......h...h.....h......h...........h....a....s....h......h.......s....h......h........s....h....h....s....shh....lh..hhsp.htt.hh.....h......................................................................................................................................................	0	83	107	256
+10156	PF10324	7TM_GPCR_Srw	Srw; 	Serpentine type 7TM GPCR chemoreceptor Srw	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2]. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz [3].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.16	0.70	-5.31	90	944	2012-10-03 04:04:29	2007-08-16 17:52:27	4	31	52	0	866	4349	0	230.20	17	73.85	CHANGED	thph...hluhhulllNlhHlhlLTRKuMRssSlNllMlGIulsDlhshhhslhphh..hhhth............cC.h.....sss.oYhhhh..hphhhtslpchs+RsSsWLulhhAllRhLll+.Phss+hppLupsphuhhllhhlhhhshshohhha.hphp.lh............p.t.hh...........C........t..h...t...sthtYhhhhschh...pthhhp.hhhhhsulh.cllPsllhPIlTlhLlh-L+Ksp+p+pphp....ppt............cscpoT+LVlhhTIsFhluEhPhGl.shhl.............phh...hhpss......sl....hhlhpphshhhshlhslNussHhlIChhMSSQYRpTs+plhttp	..........................................................................................................................................................................hh.hhshhhN.h.h.p.h.h.l..L...p.....t..h.t..t..s.h......hhhsl.shsDh.h.hh..h......h........................................................h.........h.h...h.....h.....h.................h....hhpth...u.....hals.lhh......Ah..h...Rhh....l...t...........p..........h........h..t......s.h.hh....h..h..hhh..h..h..........h.....h.........h.....h...ht...h............................................................................s..................................................a............................................................................h....h.....h...h.s..h..............h.................p...............h..........l..s....s...h...h..h...hhs.h..h.....L..h.....h.....t.........l.....hph......p........p......t...p..tth.....................t................t...................ptppoo.....h.h.l...h.h...h..hh...ahl....s.ph..P....uh..h.hh.................thh.......................................................h...h.........h..........h...h.........h.h..h.hss......p.hhlhh.hSppa.Rp.hh.hh...h.....................................................................................................	0	227	294	847
+10157	PF10325	7TM_GPCR_Srz	Srz; 	Serpentine type 7TM GPCR chemoreceptor Srz	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2]. The genes encoding Srz appear to be under strong adaptive evolutionary pressure [3].	21.30	21.30	21.30	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.98	0.70	-5.27	62	372	2012-10-03 04:04:29	2007-08-16 17:52:46	4	15	4	0	367	410	1	207.80	21	75.85	CHANGED	hhhhhhhhhhlhhhllhPFYlY...VhKlNRc+D+phhlaP.lssHFYch...l+hsYhlhhhhlhh..hhhhhhhtt...................hhhhlhhhhhhhhhhh....LhllsplFalLlhLLAlp+FllYFF.PptE+hlhhspphh.+hlhhlYlhhllK.-lhhhhhhhhph.t..................phhthhahhh........................hhhhs....lllhlSulLYIPIhISlR.Khup.Lt.SsQpspPppYIaaQolhVhlhKhlhl.hhlhhhh...hsthhhh..........hhhhhDhlooPLIIQlSYLsCN+	................................................................h................h.hahh...h...s..pcp..t.............................ha...lhp.hhath...hhh.hhhh.hhhhh...hhhh.hhh...................................h.hhh..h..hh....h.hhh...hhh........hhh....hs..psh..ph.l.l.llAl...p.....+hhlaF...h..P.p..cphh.h.pp....h...h.h.lh..hhYhhhhhh.p..hhhhh...h..h.h.h..........................................h..h.h....hh................................hh.hhp..hhhhhoshlYlP....l..h..h..pl.p.+.ht.....h..s.t.....sps.ppalhhQhhhl......h..hhKhh....h.hh..hh................h.....................hh.hhDhhh..hPhllQhoYlhCN..........................................................	0	76	76	367
+10158	PF10326	7TM_GPCR_Str	Str; 	Serpentine type 7TM GPCR chemoreceptor Str	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split [2].  Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-11.93	0.70	-5.30	178	1469	2012-10-03 04:04:29	2007-08-16 17:54:00	4	34	10	0	1456	2149	6	223.40	21	82.72	CHANGED	pphhphhuhhhuhhhNhlLlaLllt+ut+phGsYKaLMlhFolhulhaohl-hlspP...............hhHsass..ualhh.h..p.hth...spthtthhl...............s....las...uhauhsluhlulpFlYRYhulppsp.t..l.chFpGhtlhhWhhhslhhGhhWshshahhhtssp......sscal................+.pph..hcpYs.lshsclsahuhhaa............spsG..p....lphpshhshhhhshlhshsahlllahGh+hahph.pcltph....Spps+cLQpQLFpuLllQollPhlhhalPsshlhhh....Phhs....l...ph.shhushlshslulYPslDslshhhllpcYRpslh	.............................................................................................................................................................................................h........h..s.......s.h.hh...hh..h..h...........h....u......Y.+....h....hh....h...h....sh....h......t......h.........h......a......s......h..h......p..h..h..h...P......................................................h.h..............t....hhhh........t......................h........h..h..........................................hh.s.....s.....a.s.........h.....h..h...........s...h..p....Fh......a.......R.a...h.sl...............t.......................................h...t.h.h..p.................h..h..h..h.................h.h......h....s........h.h...h..h..........a.....h....h.............h....h..h..h..h.h..........s...........p..t....hh........................................p.....h......t.....h...t.....h...p.........p...p....h......h.h.s........hha......................t.p.s...................h..p.h...........s.h..h.h..h.h...............h.................h.h...h...............................h...............p................h......h...h....h.....h.hu....h....t...........h.a...h.th....pph.t...........S...pplp.p..Q..................ha...h.s.....Ll..............h..............Q..............s.h..h............Ph.h....h...hahPh...h..h.h.h.h.h....P.h.h.t....................h..ph....t...h....s.t.h.h.....h.......h.h.s.ha.Ps.h.Dsl.hhhhl.ppaRph..h.............................................................	0	456	563	1456
+10159	PF10327	7TM_GPCR_Sri	Serpentine_Sri; 	Serpentine type 7TM GPCR chemoreceptor Sri	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.80	0.70	-5.46	54	363	2012-10-03 04:04:29	2007-08-16 17:54:30	4	17	7	0	359	1625	0	222.70	22	82.08	CHANGED	hslDFssPhaLlhaaalIGslSlllNhhsIYLllFcSsKlcsF+YaLLhFQlsshloDlplohLhQPhsLaPlhuGashG..hhsph...htlooHhthshhshlhshQltuLhhCFlpKHQuIuplh..ppp..hsp....hhhhhhhhhshhaPhhsshshhhsslsc-pphcalcpsaPphhspFtsLssFslYphs...ahhhhhlhshhsshhshslhshhshchhphLppl+pplSspsYp+H+sAlpSLlsQhhsoslhh.lPshhhhhllhhthstuQ.....hIsphhhslhssHSslNslVllhosPsYR+hl	......................................................................................................................................................................h.h..h.h.....t..................t.....a.p.............h.h.h.......h.........h...Q.....h.........s.......h.h...s-....h.......h.s.....h.....l.........hp..s...h.............l.....a........P.........h...h.......u...G...a...s..h....G...hh.s.ph............................h.............s....a....h........h........s................h...h................h.......h......h...h...h...........h...p.............h.........t....s..............l.hh..C......F........h....h....K.Hp..s..l..s...t...h...............p.h.h...h...h...s...p.................h..h...h.h...h..h....h....h.....h.....h....h....h..h....s......h...h....h....h....h...h....h..............................t........h.............s....p...p.............p...p...h....t..h...................l......p................p......p............a.....P..............p........h....h............................h.......p.........h........t....h...........l........a......s...............h.h...h...h...h.......h...h.........h...h....h...h...h....h..h...h...h.....h...h.h..h...h..h.h.h...p..h...h............h...h.....t.........h...p.........p....h.....S......t...s..h....ph...a.pt.s.l........h..............o.....Lh..h..................Q................h....h.................h..s.....hhh..........hP...h..hh..h...h....h..h..hh.......h...........p.....................h.s.......h.h..h.hhs..p.u..h.s.h.hhh..s.aRth.................................................................................................................	0	104	134	359
+10160	PF10328	7TM_GPCR_Srx	Serpentine_Srx; 	Serpentine type 7TM GPCR chemoreceptor Srx	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.91	0.70	-5.29	80	586	2012-10-03 04:04:29	2007-08-16 17:54:54	4	18	10	0	579	7241	0	219.70	18	82.16	CHANGED	hhluhhGhlhNhhlhhthh+.h.shpsSFshlstspuluNslhsh.sFLha.hsPhslhshph..h.p..pohhsthhshhsYth.ushsplhlolNRFhAlahPhhYpplashphTph.......hlhhhahh.........uhhhhhlhhhhhsCthhas.phhsat..spt..hC.shh.sh.h.....hhhhhslshhsshlsllThhKlhthppph...thspt..pspp+pp+..phphhhQoshQshlahl-hlshahl.sph............hss.phhpFlssohsWhhlHshDGhlhlhFN..pclpphhhpphpt	.......................................................................................shhG.hh.h...N...h...h....h....h......h......h.....h.....p.......................p...s...u.....F..........h..l......s..h........p.sh.s.s....h....h....h............h.....h......h....h......h......h......h.h.....P..h...........h......h...........t........................h..........................s......h.......h.......t.........h.....h...h.......h....h...h.......a.................h.....s...................h........p....h....h....h...uhNRh.hslh.h.s.....h....h....h..p......p...h..h...s.h.............T...h...h................h.h.h.h..h..h..hh....................................sh........h...........h...h...h............h.........h....................................t..............C......h.....h....h........a....s.........p......h......h..........a..........................t.....................C.......s.......h............h.........h.................h..h..h......h..h.....h...........h...h........h.............h......h..h......s.....h...h...s...h....h................+....l.h...h.......phth..........................ttt......t.t..p...p...pp......p+..............ph...t...h.h..........h...Q.............s.....h....h........Q.s..h........h..h........h....h......p...h...h.........h.h..h..h......h......................pp....h...h......F.....h.....h.s..s...h.....h.....hh...p..s..h..-.G....h.lh.hh.p...ph.........t...............................................................................................................................................................	0	177	228	579
+10161	PF10329	DUF2417		Region of unknown function (DUF2417)	Wood V, Coggill PC	anon	Pfam-B_22799 (release 21.0)	Family	This is a region of a family of proteins conserved in fungi some of whose members also have the Abhydrolase_1, Pfam:PF00561, domain in their sequence. The function of this region is not known.	25.00	25.00	32.30	32.10	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.62	0.70	-4.95	21	122	2009-12-10 16:57:14	2007-08-20 13:09:06	4	4	112	0	92	118	0	228.20	36	43.81	CHANGED	sE+p.LLs.................................ptsalsPDDPt....VSPaNLap.....lRhlRslsslhlhlohlhahhhLlS.Fl....u.PuhpsRGsuFhshshshlslhh.llsLhF..FulPSphtplhuhllusLLllDhlllluVstlRhc.GWlGluollWAslhulhssltDhhV.............................thGKpc-EERL.....TGR.......EoR+oLpEWlslhlcolhhlllhllshLhTlTLhLpAhDus..................hts.GphahVDssp.apVHLsCh	..........................................E+p.LLspp.............................................tspsaLsPDDPs.......VSPYNLap.....lRhhRhlsslhlhlshlWalhlLlS.Fh....o.Puh..psRGuuFhshshshlolhs.hhsLlF....FulPSp..plhshsluslLhlshhlhluV.phRhcEGaVGlsoslWAslhulaslhtshhV........................................thGKpcEEcRL...............TGR............EoR+oLpEWhslhlps.lhhhlhhllshLhohTllL+uhDup..................hss.GphaaVDss+.YplHltCh...............................	0	18	44	76
+10162	PF10330	Stb3		Putative Sin3 binding protein	Wood V, Coggill PC	anon	Pfam-B_24989 (release 21.0)	Family	This is a family of the conserved N-terminal end of a group of proteins conserved in fungi. It is likely to be a Sin3 binding protein. Sin3p does not bind DNA directly even though the yeast SIN3 gene functions as a transcriptional repressor. Sin3p is part of a large multiprotein complex [2]. Stb3 appears to bind directly to ribosomal RNA Processing Elements (RRPE) although there are no obvious domains which would accord with this, implying that Stb3 may be a novel RNA-binding protein [1].	25.00	25.00	25.60	42.90	22.60	17.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.10	0.72	-4.30	17	120	2009-01-15 18:05:59	2007-08-20 13:31:59	4	1	112	0	92	118	0	95.00	50	22.14	CHANGED	lTPphLup.....lLLp+GPLAIRHlhsaLopplPuFuclssuKtRRLlhuALE.......uGs.cssVlFEKlGWGpWs.....A+chspPtphspphptos.u	.........ITPuhLAph+Ls-ILLp+GPLAIRHIhuaLTssVPGFutlssuKtRRLlluALE...........uGsh-ssVlFEKVGWGpWs.....A++tspssphspt......s..................	0	13	44	77
+10164	PF10332	DUF2418		Protein of unknown function (DUF2418)	Wood V, Coggill PC	anon	Pfam-B_29723 (release 21.0)	Family	This is a conserved 100 residue central region of a family of proteins found in fungi. It carries a characteristic EYD sequence motif. The function is not known.	19.00	19.00	19.50	19.20	18.80	17.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.25	0.72	-3.70	19	132	2009-01-15 18:05:59	2007-08-20 15:52:43	4	2	128	0	103	132	0	101.10	36	22.07	CHANGED	pcclapLpVW-Ps.aslplFshFSPsplllhhhh..........sssshpshhhhllhoh.hhhlhp.pFpphlcDcpllppEshpEYspKaVcP+hpshppDsslss	...............p.c-VWpLslWDPtsh..slpLFshFSPsHlllhhhhhs.......................Ssshhpslhlt.sllohph...hhLhs.pFsQphKDptllppEVhpEY-sKaV+PRhpshh+DVusp.h............	1	28	58	89
+10165	PF10333	Pga1		GPI-Mannosyltransferase II co-activator	Wood V, Coggill PC	anon	Pfam-B_50403 (release 21.0)	Family	Pga1 is found only in yeasts and not in mammals. It localises in the ER as a glycosylated integral membrane protein. It binds to the GPI-mannosyltransferase II subunit of the GPI and it is responsible for the second mannose addition to GPI precursors. The GPI-anchoring complex is a glycolipid that functions as a membrane anchor for many cell-surface proteins [1].	20.00	20.00	20.30	20.30	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.06	0.71	-4.63	5	47	2009-01-15 18:05:59	2007-08-20 17:40:11	4	1	43	0	29	37	0	180.10	31	85.69	CHANGED	lsllaLCslVlANTETapl+VP+-FPsposttpspuoY...sshlshIsL+NlshspIs....oTclssssssYV.ELscLp+sETYQVKICWTAIDPISIsDlsallIPHuTtFpGTlS-cA......RlhVpFcVpuDSYPlLsDsphVPVsVSllslKLGIPVDLYslLlYlllVl..uISlllshcPapLLc	.............h..lhhhls.hlhANTEoh......Lh+VPp..sF..s......lp...ps.....tssssht.................h.sshls...h.o..lssps..h.ophh........sssh.....ph.c.s..Tpal.cLss.....L.....p.....ps-s.Yp......IKlCWsAhcPhshpslpphhhs+.sthttohsD.h............clh..lpa..p....hh..u-..SY........s..............ppp.shlslpls...l.ss...hL.....s...IPl-lYshllhhl.ls...hhhlh................................	1	3	13	25
+10166	PF10334	DUF2421		Protein of unknown function (DUF2421)	Wood V, Coggill PC	anon	Pfam-B_39020 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.17	0.70	-4.74	21	168	2012-10-02 19:04:43	2007-08-21 09:54:30	4	10	89	0	134	204	0	205.10	18	19.91	CHANGED	PR.PsSu++tlcpsLupslcsluslastlhsahsp............sschclhuc............h.thhlpltt+LsuLpthlshLpaEhohpGhWPpppYtclpsLhp-lspLhspLhhlhspL..Pttah.cLhcpsGhhcpphhu-lhAVltMsppAL+oGssLPclhPssLsh+ph-hhcpphtstc...............................t.lshchlcspshppasVulshhhplhs+l...D-llllVKullGEta	................................................................................P.P.oupphlRpslupslhtlushYs.hlh.sthtt.............................................t.t..h...p...................................h..phh..h..p..h..ttpL.t.slpshlthhpaE.sl.tGpFP..p..p..p..Ypplhphhp.pllphl..stl.h..h...sh...p....pl...............s.............p........p....h...p..pt.l.hph.hth.........h.cp.........phh.up.lh.slhthlusulcstpsLPthhs...............h......p..h.h...h..t...........................................................h.p..thh.p.th...................hh..th...cphh..hp.hhG......................................................................................................................................	0	47	81	117
+10167	PF10335	DUF294_C		Putative nucleotidyltransferase substrate binding domain	Bateman A	anon	Bateman A	Domain	This domain is found associated with presumed nucleotidyltransferase domains and seems to be distantly related to other helical substrate binding domains.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.37	0.71	-4.55	86	1001	2012-10-01 22:14:54	2007-08-21 11:02:28	4	14	661	0	348	952	154	140.10	29	24.93	CHANGED	shaLtt.hApsulphpsP.LGhapplhsppps..ttttlDLK+tGlhPlVcssRlhALpp.................u.lpsssTh-RlctLtptGhlstchspsltcAachlhplRLppQlpph.psGp.....ssshlssspLsphERptL+-uh+hlcchQphlphca	...................................................................t.halsthucsAlphpsP..LG.hFpshhhc+..sG...ttttlDlK..ct..GlhPllchsRlhALtt.................G.hp.s...ss.Th-Rlcslh..c.t.s......lLspppupsLp-AachlhplRlcpQhtph..ppspt..........ssN.tlssc.pLsphE.Rc.tL+-uhpllpphQphlth+a....................................	1	100	229	306
+10168	PF10336	DUF2420		Protein of unknown function (DUF2420)	Wood V, Coggill PC	anon	Pfam-B_32350 (release 21.0)	Family	This is a family of proteins conserved in fungi.  The function is not known.	21.00	21.00	22.00	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.23	0.71	-4.49	13	112	2009-01-15 18:05:59	2007-08-21 11:16:24	4	1	110	0	84	116	0	106.70	27	16.46	CHANGED	shlhcssulhctols-hauslRp.h-pt.GphhssscELlLshspL-.LslsEDNlYsccIohsDllslFchLpppohpptc.slPcsLshpLo.spPRFlo+YNsLs-hscsstu	....................h..hcstulhppslsclhtuhRphlt...sphh.sssc....ELllplcsLs.LplsE..Ds...s..asp..ploLppllplaptLpppst.st....PpsLhlpLo.opPpFhscastLsphspps..s..................	0	20	44	70
+10169	PF10337	DUF2422		Protein of unknown function (DUF2422)	Wood V, Coggill PC	anon	Pfam-B_42729 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known. This family is the C-terminal half of some member proteins which contain the DUF2421 Pfam:PF10334 domain at their N-terminus.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	459	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.39	0.70	-5.70	27	237	2012-10-02 19:04:43	2007-08-21 13:24:18	4	14	109	0	197	260	1	360.00	14	36.09	CHANGED	hhhssWhh.pL.Dhtoh+lhhRshhsshhshhlhhhssshphhGsuuYLhslluhls.s.thshshhlhhhlhhhlulsluaAhu.llshhhuscsRtp..........................ssssshsssspsthhpu.hhsupsouVhslhLhht..lahhshhRs+....aphshIhs.IhsslhhsaushhPsh.tshslsttLlcPhulululshssulllFPhooshhhhpph.tuhlshL+sslphppsahpohcsss..h.................................pplcpshtplpshhstlcsshshhhhEhuhG+hsssDlpslhphlRplhhsssGLshhhphhpch........................................................sclspapp.pshphhc.......s.tc............phshpphsclh..ptlcc.hsshlcsscpuLppl....sphLphssph+...t.hh...hppptptp.phttph......tshtpphcpphpsFtsscphtLhthtp	..................................h.............s...hhhhh.........+s.ls.hlshhhh..s.shph...h.s.p.hsahhslhshhs.s.hh.hhhhl.hhhh.hhuhhhuhuhs.hlshhhu.tsh.t......................................................hpst..slhhlhhhh...hahhshhRsh.....h.hshl.hh....lhhs..l.hphushhsh....shph.sp.hhhshhhuhuluhssslhlaP...osp.thhhpth...hthlt..lpthl.ph.pht..hh.ts.t.....pt............................................................................ptl.ptth.ttltshhsthpsshthh.h-huhup..hsspDlptlh.p.h.h+plhh.h.uh..hhphh..h..............................................................................................................................................................................t.ht......hp...t......................................t.h.p.hh....htp..t.h.t.....ht.slthh.......ht.....t..........................................................................t...............................................................................................................................	1	55	107	167
+10170	PF10338	DUF2423		Protein of unknown function (DUF2423)	Wood V, Coggill PC	anon	Pfam-B_46946 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known.	27.60	27.60	27.60	27.60	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.05	0.72	-3.98	20	136	2009-01-15 18:05:59	2007-08-21 13:32:42	4	4	128	0	108	129	0	44.80	43	29.28	CHANGED	MAKSLRSpo+hps+ohKR...csVFthss-ARspRlusKLccphtppc	MAKSlRups++ps+uhhR...psVFusstcARscRLSsKLp-hhtp.p......	0	33	61	95
+10171	PF10339	Vel1p		Yeast-specific zinc responsive	Wood V, Coggill PC	anon	Pfam-B_50673 (release 21.0)	Family	This is a small family of proteins from Saccharomyces and related species. The function is not known but member proteins are highly induced in zinc-depleted conditions [1,2] and have increased expression in NAP1-deletion mutants [1]. The S. cerevisiae genes are named VEL by association with Velum formation in the wine making process http://www.ajevonline.org/content/48/1/55.abstract	23.00	23.00	289.00	288.80	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.48	0.71	-5.16	4	33	2009-01-15 18:05:59	2007-08-21 13:58:00	4	1	18	0	12	21	0	189.20	81	98.25	CHANGED	llshF.shIsl..ssAlRFDLTNlTCptL+GPHCGTYLL+VsGpNuTaLGQphFVGhDALTpstsDhatRhLcpEsRhIPRLTTlAp.N-TsNFpPhhFTTshsTCNPQSIEsAhlPFlNTVTsEIpYDSWA.Tu.NAShITGLANQLhNuosYGVQVAoChPGFssslhsoPTVNlFNs--slPSWCpAIElcAVCPhDsGFs	......hhhh.hhls...ssAhRFDLTNlTCptL+GPHCGTYlMEVVGQNGTFLGQSTFlGADVLTESAGDAWARYLGQETRFLPKLTTIAS.N-TKNFSPLIFTTNI.TCNPQSIGDAMVPFANTVTGEIEYNSWADTADNASFITGLANQLFNSTpYGVQVASCYPsFASVILSTPTVNIFup--TLPDYCTAIQLKAVCPP-AGFs...	0	4	4	8
+10172	PF10340	DUF2424		Protein of unknown function (DUF2424)	Wood V, Coggill PC	anon	Pfam-B_51256 (release 21.0)	Family	This is a family of proteins conserved in yeasts. The function is not known.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.39	0.70	-5.82	5	116	2012-10-03 11:45:05	2007-08-21 14:05:56	4	3	60	0	80	2905	696	294.20	23	74.90	CHANGED	LpFLs+llslLPItll.....hcSIsllshs+R+LslDhLoRlFhRpShhLhDctICpYVLNPla-.lu.sLaK.ph.s.o..chslPp-Dpps.psslFsc+hlNpshhpSphaWhtph.PcsFcPclD.PlLLYaHGGGaALpLsPsoLlFLsNltKhFP.cM....AILlsDYoVTAspscopcYPhQlLpslslY-YlspohGCKNVslMGDSAGGNhVLslLLY...L+KpNK.llPKKAIAISPWlNsThhsEpE+saM+ts-clDulChKuLshFG+hYlsN...-supshpo-sFlNIE+Na-h-sWscI..lcKCcLLITYGDDElLphQIKlalcKIo-hptt.pa.pscNVLl-c...QGsHIG......P.ILsassNlD+WoKhsSlscILsF	.......................................................................................................................hh..............................................................................................................................................................................p............h......Wh..h.p............t......ps..p...s.D....P...l...l.lYhH....G....G.....G.Y....h....l........p.........h....h....s....s....p....l.....p......h....L....h.....s......h....h....p.....h..l....s.....ch.............................u.I......L..l.....l.......DY.......s...L.......s......s............................p.........u...t...h........a........P......t...Q...l....h....p....h....l.....s......s........Y........p.............p......L........l......................s.........p.......G.........s............p.........N........l.....h......L.....h...GD.SAG....G..NL...s..l.s...h...l...pa........................L..p......p.........p........p...................s...........h...........P..............+........p.........s...l........LI......S.PW..l...ph...s.................p..pt...t.....t..p.....hp...t..s...p...ph.D..h.l.....s...h.....p...t..h....p..........h...t..c...hahss..............t..t..t...h.........s..h.ss.h.....tt............p...p...Wpcl.......hp....p...t......s...shlhh.G-cEhh+-plhpas.phh.............................................................................h.h.............................................................................................................................	0	15	37	72
+10173	PF10341	TPP1	Est3;	Shelterin complex subunit, TPP1/ACD	Wood V, Finn RD	anon	Manual	Family	TPP1 is a component of the telomerase holoenzyme, involved in telomere replication.  It has been demonstrated that TPP1 dimerises and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes [1,2]. Yeast telomerase protein TPP1 (Est3 in yeast) is a novel type of GTPase [3]. The key residues in Swiss:Q03096 are an Asp at residue 86 and the Arg at residue 110.  The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TINF2, whereas the C-terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex [4].  The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres [5,6]. This domain is conserved from fungi to mammals, hence family Telomere_Pot1 has been merged into the family [7]. The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear protein 2 (TIN2), TIN2-interacting protein 1 (TPP1) and protection of telomeres 1 (POT1) [8].	21.90	21.90	21.90	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.51	0.72	-4.06	51	102	2012-09-26 10:57:07	2007-08-21 14:13:12	4	1	93	2	67	107	0	118.70	21	19.44	CHANGED	sWIpphlhsthptp..................................hhtps.sspll+llca................sssssshtul............................lSDusapIhulFo.pculppac..pcpc....pchp.........tsspssllhlpchplpht...sppthssca....................................hLp.....l	....................................sWIppllhsshp....................................hhssstsspllcllph..................sssssshtsl............................lSDusapIpslho.cculpphc.....hcpc.....phhh.........psspspllhlpchplhhp...sptthssca.......................hL.................................	0	14	27	47
+10174	PF10342	GPI-anchored	Drmip_Hesp; Drmip_MAPK;	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family	Wood V, Coggill PC	anon	Pfam-B_42324 (release 21.0)	Family	Some members of this family appear to be serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. In A. fumigatus these proteins play a role in fungal cell wall organisation. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organisms as it interacts with MAPK. The family is also found in archaea and bacteria.	26.00	26.00	26.00	26.00	25.70	25.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.48	0.72	-3.51	101	635	2012-10-04 12:14:07	2007-08-21 14:16:40	4	18	172	0	476	646	9	93.20	21	35.69	CHANGED	os.P.shs.pslssG...p..hTlsWsss......sss.......ssholhLhpGss...s.hssh..tsl..ussls.su.....uo.aoass....ss..s..lssss....s..Ytlplh.s.ssss.......hsYSspFsl	..................tP.stssshssG....ps.hslpWpsst.......sss..........ssh.sl.hLh...sGss........tp..hs.sh.....tsl...us...s..ls....ss............uo..as.hss..............ss...s....lssss......s...Y....tlplh..s..ssss.......hsaSspFsl..........................	0	169	295	400
+10175	PF10343	DUF2419		Protein of unknown function (DUF2419)	Wood V, Coggill PC	anon	Pfam-B_35257 (release 21.0)	Family	This is a family of conserved proteins found from plants to humans. The function is not known. A few members are annotated as being cobyrinic acid a,c-diamide synthetase but this could not be confirmed.	19.90	19.90	20.00	19.90	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.78	0.70	-5.15	21	302	2009-01-15 18:05:59	2007-08-21 14:49:58	4	5	236	0	233	297	138	246.10	34	73.73	CHANGED	HELHPps...cD......cpTVsalFlhDhLNFuFWo-ps.........tpaslpY+G+taTGYaSLsAAlpRAL-cGIsITsPpFa...pchT.chL+c.lF+Ssot..cclPLLp........ERlcsL+EuG+VLhcca-GSahNhlpsu.spSAssLlpLls-sFPsFRDcssacG+........+..VphYKRAQILVADLWusFpGcu....h.GcFcDIDpITMFADYRlPQhLppLGsLtYospL.pcl+ppchIssGuphElElRusSIasVEhlRctlp+pcsc.t........................................................................lNAILIDaaLWDht+chptcht.........plPaHRT.......RSIaY	...............................................................................................................p........ts.......ttsspalFhhDhLNF.s..FWsptt..............h.ap.................p.hpGYhsLsAulp+Alc..p.shsl.hssphh......tpho.p.lpp.lhcs......s.t......h..Plhp......................ERhph.LpE...sGplL.......h.c.c.......a....tGs....hhshl.p.p......u......p...t....S...At......tLlpllsppFP.s......FRDtsh...a..c..G....+...............p...VthaKRAQILVADlWusa.p....G.p..u...................h..G...p..F.....p.........D.Is.p....l..T....MFAD.......YRlPQhLhphGsLpY.S.spL.ptl.....cp....t.p......l.sGsp.E..................l................ElR.u.......sSlhslEhlpct....l.........p..h..p.................................................................................................l.s.ul...hlDaaLasht+phtt..p........................lPaH+spsIaY..................................................................................................	0	93	135	198
+10176	PF10344	Fmp27	DUF2425; 	Mitochondrial protein from FMP27	Wood V, Coggill P	anon	Pfam-B_54917 (release 21.0)	Domain	This family contains mitochondrial FMP27 proteins which in yeasts together with SEN1 are long genes that exist in a looped conformation, effectively bringing together their promoter and terminator regions. Pol-II is located at both ends of FMP27 when this gene is transcribed from a GAL1 promoter under induced and non-induced conditions [1]. The exact function of the Fmp27 protein is not certain.	25.00	25.00	25.30	25.30	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	881	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.38	0.70	-6.86	29	253	2009-01-15 18:05:59	2007-08-21 15:54:39	4	23	161	0	164	252	0	580.20	17	30.91	CHANGED	hhshhllhhllphhsGlsIppl...shhSl+tlshss+s.hpIpIctlthpl.....hspsphlplhshc.lclph........................pcpppppstpppsspttp................p.hthhphph.pphh+tlhphl.calphlslhlhpsslsh.shsptthshlphsspppphhhsp.......................hph.h..lpslhhthps.....tp..pllspsslslpshlphsh.......sLcshslslpluclplPhs..shhphhthhcp.cpptspt....t...t................................psppthpplp............p.hchhpplhchlp-lplplcphpl.ch..s.tsp..sh..............lsh+plshshp+hsppsPua+hhFppc.Dhshphhhshhslplths.t........ptpsscllplPssohohcoshhp.h..........ts.spspthps......................................sllphshslooPslDlphcplshlhshhtshhhh+ph.shsptppp.............................................................h.hhpchhPphshKhslc-Phlhlphs..t.s.......hshlhtShSslshslposc...........ttptplhashhophpltshphhhps..spth+pslhphcshphch.hshhsphplphpsslss....hshchsphcl.hpulppllhplstphp.c..hthptp............................................c.plh+tLPsaltphphphoslshplus..............spslp..-htcGlshcLcshsspacthphsh.sshpthppps.Sps.s.hps................t.pt.ths-hpphs.p.p......................................sh.s.h.psscph.hcshhslsph-ltlsshscp......sshhplphplpplhsphshaphashhsulshlpphhht..tshppppppsp.hphtt........................................th.chlplchchpslplhhpLPs-sshhlplhs	....................................hhhhh.h.ph.stlpItph...thh.lptlshp.pp...p..lplctlhhp..........phh.lh..p...l........................................................p....................................................th....thhphhhp.h..ahp.lslhh.pssh....ht.......t.h.hhhspptp....................................lpph.h..............p...phlsph.shthphhh.hsh........shp.hshslplhphph.hp......h.......t...............................................................t.t.h.p.h..................hh....h.th.pphphthp.hth.........t.........................h.hp.lth.hp+.p.p.s.hp..Fp.p..shs......hhhp.sl.h..............ttp.pchh.ls.hphshpss..................................................................h.hphslsos.lchc.pphshhhthh.......pt....t..hp............................................................................................hhs.h.h............................hh..p.o.h.hshp.......................hhh...t.....t....h.......t....thh..p.hth.................ht................h.....p..h.......hp.hh.ph..............................................................hhp.hP.....h.ht.t.h...hs................t..p....p..pu....phtthshph.....t....................pt............................................................................................................h..h...p.h.h.s.st.........s...lp..h.th...hp...hhh.h.sh.hlpphh..........................................................................phhthsht.t.ht..h.hstt..hhhp................................................................................................................................	0	21	55	113
+10177	PF10345	Cohesin_load		Cohesin loading factor	Wood V, Coggill P	anon	Wood, V	Family	Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4 [1].	21.30	21.30	21.30	21.70	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	609	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.82	0.70	-6.31	21	268	2012-10-11 20:01:01	2007-08-21 16:06:20	4	10	212	0	192	312	1	467.70	23	69.21	CHANGED	ptph.hLltlA-cahpsApshsspl....pptphppYapLlshulpCLpslhp............shpLssch-AplphcluplLhpETcNhspA-shLs..+uhhlspp..sshh-lKapsphLL...splhhcos.ps..Ahptlsctlp.hps..................pptahasachLphpLslpp...t-.stAhphLppltphss.psppthhlhhhhhpshlphhps.spDslphlpph.httpth.....t..ph.pLtshhhllclhttlppsp.tsspppLptlpphhpphps.........ass..ptchtl.lth.........................hhhhpWLspcplhhLsYhloulsthhcppss..+upKahpculpphcc.h.............sl..hppphthhpslphhhhhahhhpthhhsshtpsppphp.htshspt..........pthtshhhhLtGlhtQtp.......uchcpAhthah..........................................phstspssps-LtlhusLNlhhIhpt.spppptp........................hsplhsplcshsspssspphthstshh..ltshpth.shphp......pp+pphppsLpth....p...................thspsphhshsLsllstpha.......tssst..........Epsphstp...uhphAppp................................................pstLWh.lssshhtp.hc.tGptsctcpstpphpplpp	...................................................................p.....lhthAc.hhpts...ht.h....................lpCLpslh..............php..s..p.EuhspLphuplLhpcTp.....N...p.AcphLp......+uh.....lspp..........ph.-lKapht...LL...splhhpps.hs....Ah.hlcp..hlp..pt.........................s.hath+h...l...hpls..h.....p-hstAhp.Lthhsp..hup......ssthh...hshhhl.cu.hlh.h..h...p.t...t-.sh..hlp.s....sp.h.......p....ph.....pLp.shhh..hlpls.h.l.tt.phppsp.pLptlpp.hpph.p....................tp..h..t.................................................................hh...pahspcphhsLsahl....o.sht.h.t..........s..p......+up+ahpculh.lpp.h..........................................................h.pp...hhp.h.h.hh.hhhhhthshsp.hth.s.ptht.htp................................t.h.s.hhhh.uhh...sh.......sphptA.t.a............................................hh.p.s.p...p-lhhhhshNhh.lh.t.tp.tp.............................h.plhptlps...tp...s.......sp...h......hshhhh..htsh.t...h..................ptKp.lppsLphu......p.......................t.s.sphhshsLs.hhshhhh........ssht..........Ep.phss....uhthAp+.................................................tstLW...ssshh..tp..chtspt.ctpthht.h...............................................................................................................................................	0	54	99	157
+10178	PF10346	Con-6		Conidiation protein 6	Wood V, Coggill PC	anon	Pfam-B_35316 (release 21.0)	Family	Con-6 is the conserved N-terminal region of a family of small proteins found in fungi [1]. It is expressed at approximately 6 hours after the induction of development and is induced just prior to major constriction-chain growth [2].	25.00	25.00	25.80	25.30	23.30	24.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.16	0.72	-7.45	0.72	-4.54	23	178	2009-01-15 18:05:59	2007-08-21 17:03:05	4	5	51	0	145	192	0	35.80	43	41.08	CHANGED	c-ssNlhtGaKA.............sL+NPpV........SccuKc+AcchLcchss	..................ts.sNVhtGhKA.....................slpNP....sV........S-cAKp+A+chL-pht.......	0	78	101	134
+10179	PF10347	Fmp27_GFWDK		RNA pol II promoter Fmp27 protein domain	Wood V, Coggill PC	anon	Pfam-B_5282 (release 21.0)	Domain	Fmp27_GFWDK is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic GFWDK sequence motifs. Some members are associated with domain Fmp27_SW (Pfam:PF10305) towards the N terminus.	20.30	20.30	20.50	20.30	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.01	0.71	-4.25	33	294	2009-01-15 18:05:59	2007-08-21 17:12:47	4	35	229	0	216	303	1	141.10	33	5.80	CHANGED	DYPLPllphP....sps.ph.shphpGslVluEphhps.cphRplhVPlsPsst.ptt...sshaulpl.RTlosVKhasDhphclsospsoplsWGtSYQPAlpphMtshDpFoKPslDPSs+lGFWDKlRLlhHG+hphphpp..phclthKGS...........+DPYpl	...............................................DYPhshhpl..................shplhushlhuEph.ps.cuhRphhl.ls.............pshhsltVpR....oh....sPlKhYpDhphclpo...splsWG.suapPuhpphhhsh.................-............t..ho.....K..........P....s....h....D...........PS.................t...luaWDKhR..LhhHG+hphshcp....hplph+uo...........cDPYph................	0	64	115	183
+10180	PF10348	DUF2427		Domain of unknown function (DUF2427)	Wood V, Coggill PC	anon	Pfam-B_52268 (release 21.0)	Domain	This is the N-terminal region of a family of proteins conserved in fungi.  Several members are annotated as being Ftp1 but this could not be confirmed. The function is not known.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.24	0.72	-4.46	33	258	2012-10-03 10:28:09	2007-08-22 10:51:40	4	7	134	0	196	274	0	100.80	27	18.68	CHANGED	shsssoaassspstcusLahHIhlhsluashlaPlullLuhs+.S+aalssphlthslslsGhhhutl.apuppPp...hYssNsHsphuhlLhhhhssQhshulhhpht	...................t...s.s.hh..tp.hcuh..lhhHIhlhsluasllaPl............u.h.l....L.....uhs.+...S.......R.......a....al..P...s..QhlthslshhuhhhG....t....l.....apupp...........hh..ssN.....sHsphuhllhhhhhsQllhGlhhth..........	0	51	107	162
+10181	PF10349	WWbp		WW-domain ligand protein	Wood V, Coggill PC	anon	Pfam-B_5077 (release 21.0)	Domain	The WWbp domain is characterised by several short PY and PT-like motifs of the PPPPY form. These appear to bind directly to the WW domains of WWP1 and WWP2 and other such diverse proteins as dystrophin and YAP (Yes-associated protein). This is the WW-domain binding protein WWbp via PY and PY_like motifs. The presence of a phosphotyrosine residue in the pWBP-1 peptide abolishes WW domain binding which suggests a potential regulatory role for tyrosine phosphorylation in modulating WW domain-ligand interactions.  Given the likelihood that WWP1 and WWP2 function as E3 ubiquitin-protein ligases, it is possible that initial substrate-specific recognition occurs via WW domain-substrate protein interaction followed by ubiquitin transfer and subsequent proteolysis [1]. This domain lies just downstream of the GRAM (Pfam:PF02893) in many members.	21.80	21.80	22.40	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.89	0.71	-3.20	31	266	2009-01-15 18:05:59	2007-08-22 14:06:34	4	9	168	0	161	239	0	107.50	30	39.43	CHANGED	PGGGa.Gp...spaKloFppGGAI-Fupthh+lsppsppu..ht.t...............h..shuhst.ss...Pshst......................................Ps.....................s.hssss...............ssssssa.sssssts.hhst...PP.PsYsus.....t	.....................sGGGa.Gp....spaKLoFpsGGAIEFuQthhpsssp.uppu..h.t.s....................h.ss...hshs..ss...sshsh......................................................hss.....Ps..................uhs..ss.........................................sssssa.ssss....s..s..s.hs..t...PPPsYsss...............................................................................	0	36	61	113
+10182	PF10350	DUF2428		Putative death-receptor fusion protein (DUF2428)	Wood V, Coggill PC	anon	Pfam-B_6748 (release 21.0)	Family	This is a family of proteins conserved from plants to humans. The function is not known. Several members have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these could be confirmed.	21.40	21.40	21.40	22.80	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.63	0.70	-5.36	33	333	2009-01-15 18:05:59	2007-08-22 14:57:58	4	9	254	0	238	352	4	254.50	26	17.08	CHANGED	hcphhscllshspplhphl+sllsp-o...PEGt..........................................hs-pht.......p.shssphllshuWRul+E..uShLLtsll...............................sshlotsplctlGphhhppLtpl+HRGAFpsVh.sFsshCpphhp.....spstplssLPppWLppslphlpsp...........sph....hTRRSAGLPahlsuILsucsss.......shhppshppLlclAchsst..........tsttt...p...............lPQVHAhNsl+sIFpsscLustsssaltcuLpLulcs.FsSssWu	................................................................................................................................hhpcll.hs.pl.ths.t.sll.sssu.......PEGh.....................................................................................spphp............pttsssphlLs..ssWRuhKE..s..uh..LLs..t.lht.h..h...................................................................t..s.sthl..shpp.l....cpl.Gphhh.ptLhphRH+GAFptsh.uFspl...spthhp.............sp..s.....sp..h.....p.p..L..PppWlpp.hlpt.l.psp..........................ssh..phTRRSAGlPhhltulLsu..-sppt..........sllppsh.ppLlp....lAp..sss......................................tt..p.....................................lPpVH..A..l..NhL+slFpco...pL...u...p..ps.s.a...ls.cu.h.phAlps.hsSshWs.....................................	0	85	128	197
+10183	PF10351	Apt1		Golgi-body localisation protein domain	Wood V, Coggill PC	anon	Pfam-B_6317 (release 21.0)	Family	This is the C-terminus of a family of proteins conserved from plants to humans.  The plant members are localised to the Golgi proteins and appear to regulate membrane trafficking, as they are required for rapid vesicle accumulation at the tip of the pollen tube [1]. The C-terminus probably contains the Golgi localisation signal and it is well-conserved.	20.20	20.20	20.20	20.40	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.32	0.70	-5.63	41	368	2009-01-15 18:05:59	2007-08-22 15:48:38	4	35	242	0	260	388	2	417.80	21	19.93	CHANGED	llp+sShhh....hYsphsshthp.............ssttphcs...........hcplslphPclhssssSpQYhs..lYsIltsLLhas-Phccph.pc+lc+lhhshDhp..Dlpuhs.phlppLQpcl+pLtplppphph+pphLspps....................................htchhhlph-htpstt-Lhhlhpslpssptc..........pp...sspsshpaplpsccllW+llc-sppPhl.-htLssspapRpcsscGSshNplplphlpshNLh.sAhYspllsPa.p.............s.psscpshlclpWphttslGGIsVh-chclslhPLplpl-cchsc+lhpYlFPsppsp....................cpssspctpppsthshsstsssptstps.........................................................................................pt.t..s.tph.spssppt.pspc.tht...................p--lscMhpRuppahsltpl+lsshhlplSYK.....Gpsptpl.sVpDhhhplPslcYcNpshohhDLhhplKKcll+sllpHsG	............................................................................................llppssh.hhY.phs....p..........................t.....t............t.hcphtl.h.p.l..phtssu..tQY.h..hh.ll.sL.Lhas-..P.cc.h.pc+hp+.lhht.-hp...shtt...p.l.phQptl+....p....h.thh....pp.....hphp..h.l..ppt..............................................................................................................ph..hptp.hthptt.....cL..hhhpshpptphp.....................................tp...ssphhhphphthpphhWc.hhpcp........sp...........h..l..-htlpph.a.........s+hppt-.........sos.p...hlplt.h.hhNL......h......s..ss..hY......p..l..ltPh.s................t.scp.hlclh..hp.......hh.sluG.I.s.lh-.p.FE...lslhPLplpLpcphhcchhpahFPs.t............................................ctppspptppts...h.h..ss.sssp.tt..................................................................................................................................................................................................................s......pt.st....s...ttt..pt..ph...tht............................s--lscMhpRupp.....hphh.lKIspl..lplSYK..................Gptp...........t.....sl.....p-h.hhhPslcapNpTaohhDhhhtlK+chh+sllpps..................................................................................................................................................................	0	84	144	224
+10185	PF10353	DUF2430		Protein of unknown function (DUF2430)	Wood V, Coggill PC	anon	Pfam-B_67886 (release 21.0)	Family	This is a family of short, 111 residue, proteins found in S. pombe.  The function is not known.	24.60	24.60	24.90	210.00	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.50	0.72	-3.87	2	3	2009-01-15 18:05:59	2007-08-22 16:11:30	4	1	1	0	3	3	0	107.00	75	94.13	CHANGED	MLLLhhICClFlKhlLApVsLTFV-YAKLPspYAELLANhhsQpGlMLFsTuDlRItAYNYLlNslTEhNsDTDAYLCQLLTGQYTTDCYIFssss.-tPEshNsSh	MLLLFCICClFIKLVLAEVNLTFVDYAKLPPKYAELLANLTDQHGlMLFDTADVRIEAYNYLVNNITEINTDTDAYLCQLLTGQYTTDCYIFDDSVYEGPENINPST	0	3	3	3
+10186	PF10354	DUF2431		Domain of unknown function (DUF2431)	Wood V, Coggill PC	anon	Pfam-B_6967 (release 21.0)	Domain	This is the N-terminal domain of a family of proteins found from plants to humans. The function is not known.	24.70	24.70	25.70	25.00	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.31	0.71	-4.29	47	435	2012-10-10 17:06:42	2007-08-22 16:42:22	4	23	253	0	309	432	13	160.90	28	42.77	CHANGED	LlVG-GDFSFuhuLhppht...sssLsATohDot.ppLppKYs.pht..pNlptL...cptGspVlaslDspphtpph...........................hpppp.FDpllFNFP.Hs.........G...tt.tp.....sppplp..............tppcLlhsFFpsupplhpt...................................tGclhlohtsGpP................Y.spWslc.tLAtc..sulplhcphcFphp..saP..GYcp+cs	........................................LllG-GsFSFuhuLh......p.......t.......ht........................st.....p..lhATsh-s..ppl...........htcYs..pst......psl.ptL.....cp......s....s..pl..h.aslDspphtpth..................................................................................ptt...aDpIhFNFP.Hs..................................G............pttlt...............................hpppLl.htFFp.s.stph.l.t.................................................................................tGplhlohhpsps........................a.s.Wpl.....thAtp............suhhl..pt.h.Fphptas....GYpptt.h......................................	0	87	175	257
+10187	PF10355	Ytp1		Protein of unknown function (Ytp1)	Wood V, Coggill PC	anon	Pfam-B_7247 (release 21.0)	Family	This is a family of proteins found in fungi. The region appears to contain regions similar to mitochondrial electron transport proteins.  The C-terminal domain is hydrophobic and negatively charged. There are consensus sites for both N-linked glycosylation and cAMP-dependent protein kinase phosphorylation [1].	25.00	25.00	29.90	48.70	21.30	22.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.82	0.70	-5.19	36	273	2009-01-15 18:05:59	2007-08-22 17:18:04	4	5	134	0	199	267	0	266.30	38	48.98	CHANGED	lhuaVpl...shGslshhGascGpclhssLAHaIhGulFhhYGll.hu.hhGhhhphGhAW....................................ch...t.................ptthStEFh-ShlIhhaGssNsFhEHhuutss....WotpDLQHsSlullaauuGLsGlhlpppt.........................................................s.thuhNshPullIhhTGhhMSpHpQps.lSThlHt.aGhhLhuuuhhRhlphhhlhhcss..................ss.shsspsshphlssFsLlsGGllFMtSo--hlpshcthGh.sthhhhslshuhshLlhsWhhlLlt.l+sa	.....................................h.hualphhhGslshhGas+usclhpsLAHaIhGusFhhYGll.....hshhh.lG.sW...........................................c.............................p.sshStEFh-ShlIhhaGs..sNsFhEH..hhG.ts.....WotpDlQHsohu...llaauuGLsGhhlppcp...........................................................s.t..phN.lPullIhl.TGhhMSuHsQp.hlSThlHs.aGhhLhuuuhsRllphshlhhc.s.......................................ss.shssh...sshp.hlssFsLhuuGllFMsu......T--plphhpphGh.sthhhhhlhhuhshllhhahhlllt.lhs.............	0	50	107	167
+10188	PF10356	DUF2034		Protein of unknown function (DUF2034)	Wood V, Coggill P	anon	Manual	Family	This protein is expressed in fungi but its function is unknown.	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.38	0.71	-5.12	11	178	2012-10-11 20:44:46	2007-08-23 13:34:52	4	3	128	0	140	242	59	117.60	28	61.05	CHANGED	STlapGTLYEhpVtphLpppLtshsLc+sGGutDuGlDlhGpWslssh.............s......s..............................hpsLcVlVQCKuhps.KluP+hlRELtGoasphsst...p..pssTlsIlsSPp.hT+sulphhsphslPllah+lsh.p...................htDG....hphs.hNsstLptha.NshuctlL	......................................ossh.GshaEhhs.t.Ltph....hhpL.+hG..Gt.DtGlDlhG.W.ls......................................................................................t.lpllhQCKs.pt...+h..sPt.lREL..Gsh........th...t..........................t.th....h...hhhhs.p.hT.thh..h.p.t.....hPhh.....hh..h.........................ts.....................................................................	0	38	73	116
+10189	PF10357	Kin17_mid		Domain of Kin17 curved DNA-binding protein	Wood V, Coggill PC	anon	Pfam-B_7469 (release 21.0)	Family	Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle [1].	25.00	25.00	26.10	26.10	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.78	0.71	-4.49	30	331	2009-01-15 18:05:59	2007-08-30 09:51:48	4	10	284	1	245	323	2	125.20	44	35.57	CHANGED	Rphtlhup..sspphl-saSppFppsFlpLL+ppaGpK+lpANplYpEaI.pD+cHlHMN................AT+WpSLTcFl+aLG+pGhC+V--o...-+........GhaIpYIDpssEslp+pcthp++c+t-ps-E-pppchlpc.Qlc	.........................RQhhlhup..sspcalcpaSp-FppsFlpLL+ppaGpK+V.psNplYpEYI.u-+cHlHMN................ATpWtoLT-FsKaLGR.pGhC+V-ET-K.....................GhaIpaIDc..sPEslpRppt.hp++c+t-hsDEE+ptchIccQlc................	0	81	133	200
+10190	PF10358	NT-C2	Eeig1;	N-terminal C2 in EEIG1 and EHBP1 proteins	Wood V, Coggill PC, Zhang D, Aravind L	anon	Pfam-B_7857 (release 21.0)	Family	This version of the C2 domain was initally identified in the  vertebrate estrogen early-induced gene 1 (EEIG1) [1], and its Drosophila ortholog required for uptake of dsRNA via  the endocytotic machinery to induce RNAi silencing [2].  It is also in C.elegans ortholog Sym-3  (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1  (EH domain Binding Protein-1) that regulates endocytotic recycling  and two plant proteins, RPG that regulates Rhizobium-directed polar  growth and PMI1 (Plastid Movement Impaired 1) that is essential for  intracellular movement of chloroplasts in response to blue light [2]. 	25.20	25.20	25.20	25.30	25.00	24.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.67	0.71	-4.70	76	744	2012-10-10 12:23:49	2007-08-30 13:20:29	4	14	252	0	483	711	0	146.10	20	19.43	CHANGED	ppcphKaphplplcclpshst......................ssplhlph.+csspt..........................................ttpstph.lppspspap....pphphssplhhs.....tcst......hppKhhpl.lht.....................................tpspp......hlGpsslslupass.......................tpstspphhhpps.....tps.suplplslphp.hpts.pt	.................................................................................pt.Khph.hphpcl..s.sh......................sshlhlph.phhstt...................................................................................................phpsshtp......l.t......p.s..plpWp......cp.hphs.splhts..........spst.....................h.csp...hphsltpp..........................................................................................tsu+p....thLGpsslNLucassts........................................................................................tss.shph..hLcsh......ts..suhLplslph.hhpts.................................................	0	138	264	379
+10191	PF10359	Fmp27_WPPW		RNA pol II promoter Fmp27 protein domain	Wood V, Coggill PC	anon	Pfam-B_8838 (release 21.0)	Domain	Fmp27_WPPW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic HQR and WPPW sequence motifs. and is towards the C-terminal in members which contain Fmp27_SW Pfam:PF10305.	23.20	23.20	23.50	24.60	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	475	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.55	0.70	-6.08	29	179	2009-01-15 18:05:59	2007-08-30 16:16:13	4	19	134	0	139	186	1	450.00	27	17.85	CHANGED	GLKu+h-shhlDLHQR+E.hpphp.....ctLs..+pp+lh+h+hptu-lchpshDlRslsAtFppsshsshhpst.p..pt.......................................asI.DsD...hsWhDhcDFlElchhtspss.P.chcIhPLhaoP+FoYhRcsstpsp.sspst...........................FGsEsoHsChh.tpscPtpsQhcLlc-RlppLccplpphpctltphp...........s.t.p.tphcph.pplppLtc+lchlpshlpchpppp....ptpptssssp..tp.t.t..............................ssstpssusFcNRFhlHNhpLKWNsslRshll+YlHplspR+uhsaahSp+ulchlp-llccppctppssppphpp............p......ppsppss...........................pphh-ph-chLp-spp...............................s.sapsppsYhlclIuPQIQLpS-csPcusVLloA.shcl+llsl.....hDppssssslss.llppRaslhhcsuphFVhp+c-h.sh..thhassssYGsp....tosWPPWLslEls	....................................................................................................GlKs+h-shhlDLHQR+E.hpths.....cths..pp.pcs.ph+hptuplchtssDlRslsuthttsshpphhp..st.t...t......t...s................................phsl.D.pD...hsWhDh-DFlE.lphh...sp.ps.P...chcIhPlhasPRhoYaRpsshs.th..sps..........................................................................FGsEsoHtChh.tpscPtplQhpLlpcRlppLctphpphpctltc.p.............t.t.t...tphc.h.pphp.Lpp+hphlpshlpchptp.....ttptt..t.ss......tp..t.....t..t........t...................................................ssstphtupFcNRFhlHNhpLKWNsslRslll+YhapsspR+uhhaahSpcAl+hl.-llc...cptpsppp.pttttpp........................t.......tp..tpppss...........................psh..-phcplLp-spp..................................................s..chssppsYhlcLIuPQIQLpS.-....cs.c....usllloApshpL+llsl........hDppphs.s.slss.lVppRasl.hcssQhFlhppcph.p........h.hassstYGs.....tstWPPWlshEh........................................	0	38	79	125
+10192	PF10360	DUF2433		Protein of unknown function (DUF2433)	Wood V, Coggill PC	anon	Pfam-B_83000 (release 21.0)	Family	This is a conserved 120 residue region of a family of proteins found in fungi. The function is not known.	21.40	21.40	21.70	22.10	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.80	0.71	-3.83	10	111	2009-01-15 18:05:59	2007-08-30 16:29:41	4	7	104	0	85	111	0	122.90	51	18.13	CHANGED	YGlSYNEFSVssoh.......EsYRuKLupu+ssFs-lW-sVKsEV-.ssls........pp-sQppLLchuLulh-Kl.Psusssu.shhhshsh.ps.......tsAhh..shWpasLs..DuuaGphlLp.IsDu+luuEhpupGFNhucR	....................YGSSYNEFSVNPoL.......DHYRGKLAASKASFNDVW-TV+uEVE.sAIs.........pN-uQpsLLcNALslV-KM.PosAsGGN..PF.GG.Pssss.su...t.....GplDESAFK..NhWNFNLA..DAAFGaLVL-.IpsGRIuTEMRAQGFNFuHR...........................	0	27	50	73
+10193	PF10361	DUF2434		Protein of unknown function (DUF2434)	Wood V, Coggill PC	anon	Pfam-B_84994 (release 21.0)	Family	This is a family of proteins conserved in fungi.  The function is not known.	25.00	25.00	63.30	47.80	19.70	18.60	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.82	0.70	-5.35	10	63	2009-01-15 18:05:59	2007-08-31 08:48:38	4	3	61	0	51	64	0	270.70	46	54.05	CHANGED	YSNGTLSNGopCYLuFspapPph....hpNGTFlNGTSCYuPlpsIGs+uulGlAaAlhFululhlTLlNLRKHG+paLPs-KRaphl..................GRRhpWaWhLFluACGhISsFhoIDVDRsYL.usPllLpSlFapLhhPGhhAAVWEAVRHWGSWQERQllD..+DPaAFscsupRp+tEhlLPllFYlFshlNFFLsVPRSWouIEhQRs.-QphppApPsATDsRFKAAuFltluuhLllsYSLcHSIY+Y+s+spushsp.llFalptsPspFllsl.....sLsulplGYulAuAFsaslSP...L+hs	......YSNGTLSNGS..pCaLsFp.YpPth....hsNGTFlNuToCYsPlpslusRuulGluFAshFulslhhoLlsLpKHG+haLPh-KRah.l..................GRRWQWYWhlFlsAsuhlShFhslDVDR.YL.thsllLpShFaaLhh.uhlAhVWEuVRHWGSWQERQhhD...Dsa..shp.pcspRp+.EhaLPLlFYlFhaLNFFlslPRSWstlphQRo.-QphshAtPsATDsRFKuuuhhhhsshllIsaSLtHSIh+Y+s+spuhhsp.hhhh.lphsPh+Fhl..sI.....sLsulhluathhsuFpashSP...l+h........................................	0	8	22	39
+10195	PF10363	DUF2435	DUF2435; Pmp3;	Protein of unknown function (DUF2435)	Wood V, Coggill PC	anon	Pfam-B_7476 (release 21.0)	Domain	This is a conserved region of approximately 400 residues which is found only in eukaryotes. It is associated with HEAT domains Pfam:PF02985 in all members. The function is not known.	23.00	23.00	23.00	23.30	22.90	21.80	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.13	0.72	-4.09	40	249	2011-09-19 22:45:39	2007-08-31 11:17:15	4	8	223	0	180	258	0	93.40	27	9.87	CHANGED	ssppthccAlpsLsDPLlPlRA+GLhhLppLlppcS...............slhslstlLslaLppLcDp.......DsFlYLNuI+GLusLs-hpsc.plLppLsphYsspspp	............................................s..pthpcslppl...p..D..s...sP.lRAtGLphLppLlcpcs............................slhp.h.ptlL.p.lhL.p.tLpcp.......DsalYLsuIps..l....ssLushh.Pc.plltpLhcpYhstp..p......................	0	57	93	146
+10196	PF10364	NKWYS		Putative capsular polysaccharide synthesis protein	Wood V, Coggill PC	anon	Pfam-B_99492 (release 21.0)	Family	Found only in Vibrio species, pombe and one other fungi, this is a the N-terminal 150 residues of a family of proteins of unknown function.\	   There is a characteristic NKWYS sequence motif.	21.40	21.40	21.90	31.50	19.20	20.80	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.85	0.71	-4.44	6	61	2009-01-15 18:05:59	2007-08-31 15:01:44	4	5	39	0	17	63	6	135.80	35	42.11	CHANGED	s-thhpDspshchERsphLhE.sF-cahNppYshpWFDNEIKplhGIDVaspsFspssGaQTapNcphSllVI+s-KLsp.tspslu-FLs.pshslVp-NpucNKWYSslhp-FKsoYp.ss.Fl-cMhsS+Lo+HFaops	......................h-thhpDs.thc.-hs..h.E.sF-p..ahNhpY.hsWFDNElKpshGIDVhppsFDpspGa.s..apscphslllI+sEpLsp.hspslu-F..Lsl.p...shslp.p.sNpucNKWYSs..lapcFKppaphsptahppMYsp.Lh+HaYop......	0	4	9	13
+10197	PF10365	DUF2436		Domain of unknown function (DUF2436)	Mistry J, Wood V	anon	Pfam-B_5683 (Release 22.0)	Family	This domain is found on peptidase C25 proteins and has no known function.	25.00	25.00	25.40	33.50	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.98	0.71	-4.61	3	36	2009-01-15 18:05:59	2007-09-05 10:47:55	4	9	9	0	3	38	1	156.60	60	14.28	CHANGED	ARpVcGIu-ulhVolEDAs-.lRoGpAcIVLsAcsVWsDuSGYQFLLDADHDTYGsVIP.DTGPLasNsoVPSNLY.AsFEYpIPuNADPusoTQNhIssG.oAcVsIPuGTYDYsITNPpP.suKlWIAGsGGspPARhDDYVFEAGKKYTFTM+KsGSGDGT-L	................uRpVctIt-hlhlolcsAs-.lRA.spA+lVLtAcsVWGDsTGYQhLLDADHNpaGuVIP.sTGsLas.s.ossusLY.AsFEYhlPuNADPssTspNhIlsG.pupVsIPuGsYDYsIsNPpP.suKhWIAGDG.stPuRhDDasFEAGKKYpFTM++sG.GDGT-h..........	0	3	3	3
+10198	PF10366	Vps39_1		Vacuolar sorting protein 39 domain 1	Mistry J, Wood V	anon	Manual	Domain	This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex [2].  Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [3].  In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange [1].  The precise function of this domain has not been characterised.	21.40	21.40	21.40	21.50	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.46	0.72	-4.03	23	369	2012-10-11 20:01:01	2007-09-05 13:18:27	4	21	253	0	253	369	0	105.10	34	11.14	CHANGED	lDTsLh+sYhhs.pssLlusLLRl..NaC-hchscphL.............ccpppap-Ll-hYas+phHccALcLLpcluc.............ttss.hpshppt.......lpYLppLssspl-Llhc.....aucWlL	....................lDTsLh+sYhts...ss......s.........l.lusLlR..........lt..NaC..clccs....pc.hL.............ccpp.+as-Ll.LYp..tKshHccALplLh.chup..........................pts.sshpshpcs.......................l...pYLppL.s..s..ppl....cLIhcautWlL.............................................	0	75	128	200
+10199	PF10367	Vps39_2		Vacuolar sorting protein 39 domain 2	Mistry J, Wood V	anon	Manual	Domain	This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex [2].  Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [3].  In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange [1].  This domain is involved in localisation and in mediating the interactions of Vps39 with Vps11 [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.39	0.72	-3.88	24	612	2009-09-13 14:58:24	2007-09-05 13:18:58	4	31	283	0	445	603	4	104.40	22	11.03	CHANGED	LclLspHus+lsshpsLpL.............LPsshslpp......lpsalppslRppsppp+psplhpsLhpucplpspcphh..............ptcspplhls-pph.CslCcK+lGs.SsFshaPsu.slVHatCtcc	.........................plLppaus..pl.cst.plLpl.............l..Ps..shslpp...............lps...aLtpsl.c..p.ts.p..ptc..p..splhps....Lt.p.u..c..t..l..p..lp.tc..hh.........................pt.pp.pthhl.sp.pph.C.hCpc......tl......s...........s......s.....s.........hsh.a..Ps.s...hhh.Hh.C...p........................................	0	180	269	381
+10200	PF10368	YkyA		Putative cell-wall binding lipoprotein	Coggill PC	anon	Gene3D, pdb_2ap3	Family	YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity [1].	22.00	22.00	22.10	22.00	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.32	0.71	-4.98	17	458	2009-09-13 15:40:04	2007-09-05 15:38:52	4	3	358	1	37	198	2	195.40	42	93.56	CHANGED	shhuhhlLsGC.hspcst-plasthEpAscpE+.shppptcpLppLEcccpcLYppllp.sh-c.cplhphs-pAlpsspcREchlppEK-ulccupcEhcsscphh-cI-Dcch+cpAcplscshccRYcuapphhcsYpculph-K-LYphLpccchshcpls-plcslNpsYcclpctpccFNchTccYNctK.sFYctutlc	.................................................................................s.hhSssLLAGC..hscK.....csh...h...pth-phtcpEc.slhssuKKlpcL-cctpcLappl.....spc..cstshtKtlcphlcNsD-RtK.hcKEc-ulcKupp-hKpAcsal-pI-sc....th....+Kp....scpl-cshKc+YchaschscuYpKAl....spEKpLachLppp..-sp.pslsEKsKslspsYKclpc.p-caschhpchscEK.sh.p.....................................	0	7	19	28
+10201	PF10369	ALS_ss_C		Small subunit of acetolactate synthase	Coggill PC	anon	Gene3D, pdb_2fgc	Family	ALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase.  Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in branched-chain amino acid biosynthesis. This reaction is sensitive to certain herbicides [1].	22.60	22.60	23.00	24.00	21.80	22.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.13	0.72	-4.25	160	3802	2009-01-15 18:05:59	2007-09-06 10:36:43	4	13	3503	7	996	2241	1813	73.70	39	42.97	CHANGED	cRELhLlKVpu.ss..psRsElhplsclFRA+lVDVstco.hslElTGsssKlcAhlcllcs.aGIhElsRTGhlAls.RG	..........pRElhLlKVpA..su.....psRs....Elhchs.clF....Ru..pllDVoss..s.hslp.l.........oGsscKl-Ahlphlcs..hu.I.hElsRoGssulsRG........	0	309	658	854
+10202	PF10370	DUF2437		Domain of unknown function (DUF2437)	Coggill PC	anon	Gene3D	Domain	This is the N-terminal 50 amino acids of a group of bacterial proteins annotated as fumarylacetoacetate hydrolase-containing enzymes. In most cases members are associated with FAA_hydrolase Pfam:PF01557 further towards the C-terminus.	21.30	21.30	21.30	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.24	0.72	-3.58	44	659	2009-01-15 18:05:59	2007-09-06 11:59:18	4	1	623	6	229	541	241	53.70	35	20.45	CHANGED	M.+lsRF....sssss.spaGhlE.G-s........lt..lsGsP.F.sshp.TGpphsLu-..V+LLAP	............M.RluRF......stsss..ss...aGhl-..sss................lt..lsGcP..a..u.......ss..ph..T.......G..pp.asLs-..VRLLuP.............	0	74	162	205
+10203	PF10371	EKR		Domain of unknown function	Coggill PC	anon	Gene3D, pdb_2c42	Domain	EKR is a short, 33 residue, domain found in bacterial and some lower eukaryotic species which lies between a POR (pyruvate ferredoxin/flavodoxin oxidoreductase) Pfam:PF01558 and the 4Fe-4S binding domain Fer4 Pfam:PF00037. It contains a characteristic EKR sequence motif. The exact function of this domain is not known.	19.40	19.40	19.40	20.30	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.90	0.72	-4.40	113	1931	2009-01-15 18:05:59	2007-09-06 16:54:57	4	33	1656	20	330	1395	43	62.40	40	5.31	CHANGED	ss....ttp..tts........hst..ps.........P.........cFVpplhtshhutcGDpLPVSuhs....tDGTaPsGTupaEKRsIAl	..........................................ssps..........hhss...ss.....P..........-FV+slstsh.AtpGDsLPVSAhs....sDGTaPhGTopaEKRsIA......	1	159	261	304
+10204	PF10372	YojJ		Bacterial membrane-spanning protein N-terminus	Coggill PC	anon	Gene3D, pdb_2fb5 	Family	YojJ is the N-terminus of a family of bacterial proteins some of which are associated with DUF147 Pfam:PF02457 towards the C-terminus. It is a putative membrane-spanning protein.	20.10	20.10	20.20	23.20	19.80	18.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.31	0.72	-4.11	6	127	2009-09-11 10:46:57	2007-09-06 17:03:14	4	1	127	3	15	76	0	68.40	58	33.78	CHANGED	McphphSEtpaKsphppalcpIpt-huhlhpTlDEcDpClLC-hE-LpHhhs-hQslASSaYLQoYlp.F	..........MpEWGLSE.ELKIQTKQMIElAE+ELS....lMRpAID..KEDECILCKMEDIHHhLuNVQTLAATYYIQAYLSPY	0	5	9	10
+10205	PF10373	EST1_DNA_bind		Est1 DNA/RNA binding domain	Mistry J, Wood V	anon	Pfam-B_24280 (release 22.0)	Domain	Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1][2]. This is the DNA/RNA binding domain of EST1 [3][4].	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.67	0.70	-5.19	69	696	2012-10-11 20:01:01	2007-09-07 14:14:08	4	18	255	2	489	771	76	252.20	17	29.44	CHANGED	AhpYYphAtplhPssGpsaNQLulluhh.s...ssc.......................hpAl.YaahRSl.hsppPh.ssApsNLhthacc..........................................................................htphhptp.ht..........pttphhpphhhhFlpLhuhhaps..........hshpphspltppl..hpplphhLpp.........................................thhstphll+hlslslhshchhpp..................................t.......s...hphhhthhthlhpphsphh.............................pptsssspphLssl+l..hhsW..lttpsshhp...............ptpptphtt...hhthhsphlshhpth.....................h.sppts...pshhL.EDhp.......hpuFtPlttsh	...................................................................................AtpaYhpAhplhPps.Gp.sasQLAlLuh..p.........tpp......................................lpsl.a.aYhR....ul.ss.p..P....a...sAppsL.phhpc........................................................................................................t.p...............ptt..hpp..hhh..Fl.thpuhl.aht.........................shp.....p..h..t.t..htpph...............hpph.ph..hl.p.............................................h.st..h....hphhh....ls.hhshpthp..............................................................................p.....hthhht.hhthlhpth......................................................................................................t.......t..Ls.lph.....ta..hh............t...h..........................................................................h...h...hh............................................h.h.E-.........h.th.......h...................................................................................................................................................................................................................	0	147	237	365
+10206	PF10374	EST1		Telomerase activating protein Est1	Mistry J, Wood V	anon	Pfam-B_39673 (release 22.0)	Domain	Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1][2].	21.70	21.70	21.90	21.70	20.90	21.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.52	0.71	-4.16	27	478	2009-01-15 18:05:59	2007-09-07 15:36:39	4	10	230	2	319	468	0	120.60	24	12.61	CHANGED	ttpclcphLWcphaYplhpha+ph..................tpp.ph..phcplppth.palcpuhtFYpsllppltspYp.ls.hphh.......................................................................t....t.pth.thssph.phslhssaRsLlhLGDlpRY+s.htpss	...............................................h..pplEphLWppsahphIpt.h+t...............................................tpppps..sptp.clp..st..hppa.LctupsF....Ypp..Llpclps.pap..lpl.phh.................................................................................................................t......t.tt.p.t.hs.s.hsp.tt.hp.h...s.hh.ssp+CLlpLGDluRY+ppht...s............................................................	0	90	150	233
+10207	PF10375	GRAB		GRIP-related Arf-binding domain 	Wood V, Coggill PC	anon	Wood V	Domain	The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localised to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane [1].	19.70	19.70	20.90	20.80	19.60	18.30	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.23	0.73	-6.26	0.73	-4.00	14	129	2009-01-15 18:05:59	2007-09-07 16:52:08	4	3	124	0	96	131	0	19.00	51	3.40	CHANGED	psccsVD+clloNlllsFL	...ps--sVD.R...cLVTNhlLpFL	0	28	56	83
+10208	PF10376	Mei5		Double-strand recombination repair protein  	Wood V, Coggill P	anon	Wood V	Family	Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.	21.10	21.10	21.60	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.41	0.70	-4.82	8	105	2009-01-15 18:05:59	2007-09-07 17:46:31	4	3	85	0	69	109	0	182.80	26	84.00	CHANGED	ssslssppssh.h.pt.ssss.pstps+pPhusoL+E+L..+csRhpppshss.lKcl+l-spcscpshst.sts.............cph-SEspppps...h.c.+slCp.-ppphpsuosstls+..uhpchh+ccLcpcKt+Lp+Qlc-..........cpDpLRRLclV+hhchKNp.pcLppLI+KW++suQptLpcLpuhlu-..............pEs-..........chTLoELlspaGlD.sLlaaN	..............................................................................h................................h.tshtp.h..........pcht.p.pp...hp.hp.hp.cppp..p.t...........................hh.st..pt.p..p.h..p.hshs....p.p..h.ssshs..t.hp.p.h.s.pch.cpplpp.-Kt.......+L....cQlp-...........cc-hLR+LchVcha+.tKsp.ppLptLIcKWRsssQ.hLh...-Lp.pth.sp..........................................................-sc.................chohspLlcphslD.pLlaa....................................	0	21	32	49
+10209	PF10377	ATG11		Autophagy-related protein 11	Mistry J, Wood V	anon	Pfam-B_21462 (release 21.0)	Family	The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex [1,2]. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy [3].	21.40	21.40	21.50	23.60	20.30	21.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.94	0.71	-4.25	28	284	2010-01-13 17:17:44	2007-09-10 14:03:15	4	6	233	0	202	291	0	141.20	27	11.99	CHANGED	apsulh+RhcDlEph.....A+KlpK-s+stcpchpphtpc...KIuhcsFchGDLsLFLPTRpp..................................................................tt.ps................WAAFNl..usP+YFL+spstt.................................plcs................+-WhlGRlsclEcpsV.......................................s.cssNPFcLucGspWYhV-App.	.........................................................................................cph.p.+p.hpt.pp..p....hp.phpp-...........KIuh+sFphGDLsLFl.scpps....................................................................................................................................asAFsl....usspYFL+ppsht......................................................plps.............+sWll.u+lhchEpphsc.........................................cspN.acLshGs+aYhlcss.....................	0	59	107	164
+10210	PF10378	RRM	RMM; 	Putative RRM domain  	Griffiths-Jones S, Coggill PC	anon	Griffiths-Jones S, 	Domain	This is a putative RRM, RNA-binding, domain found only in fungi. It occurs in proteins annotated as Nrd1 yeast proteins, which are known to carry RRM domains.  It is not homologous with any of the other RRM domains, eg RRM_1 Pfam:PF00076.	19.30	19.30	19.60	22.50	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.66	0.72	-4.38	7	104	2009-01-15 18:05:59	2007-09-10 15:38:39	4	10	104	0	79	99	0	54.50	47	6.11	CHANGED	.hP....hP.TPFDhsYGtSLLPSpLLhGSPalssPtpsssh.usphusthshstpphp	.........t.........PsT.s.FDMsa.sPLLPSQLLlGSPF..QPGoPuuF.sSPQFpshtshtptp..t..........................	2	12	38	65
+10211	PF10379	nec1		Virulence protein nec1	Mistry J, Morningstar A	anon	Pfam-B_11405 (release 21.0)	Family	This is a family of virulence proteins that are found in pathogenic Streptomyces species.	20.00	20.00	20.60	24.50	19.30	16.50	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.28	0.71	-5.01	2	20	2009-01-15 18:05:59	2007-09-12 16:07:43	4	1	14	0	1	7	0	165.00	91	84.55	CHANGED	hNLKIRTLGDLMRTSGVTPKTQSSSPKRRVLTSLATILAASGVVVANPSAAFANSTFTAVGYCDTNYQCAGGSGSSSRWSVNFDDGPTVSTIDLHELYRDQSDTMSSFRILGSVMSRANHPNETVTIHQQFYRDNGGQVPLGEYETRFRASSSNNAQRFNFDQGIPNLPWNDQVSSVAIWITRK	.........VNLKIRTLGDLMRTSGVTPKTQSSSPKRRVLTSLATILAASGVVVANPSAAFANSTFTAVGYCDT.NYQCAGGSGSSSRWSVNFDDGPTVSTIDLHELYRDQSDTMSSFRILGSVMSRANHPNETVTIHQQFYRDNGGQVPLGEYETRFRASSSNNAQRFNFDQGIPNLPWNDQVSSVAIWITRK............	0	0	1	1
+10212	PF10380	CRF1		Transcription factor CRF1	Mistry J, Wood V	anon	Pfam-B_25525 (release 21.0)	Family	CRF1 is a transcription factor that co-represses ribosomal genes with FHL1 via the TOR signalling pathway and protein kinase A [1].	25.00	25.00	32.80	32.80	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.81	0.71	-3.78	13	51	2009-01-15 18:05:59	2007-09-13 14:50:17	4	1	43	0	32	51	0	121.50	44	16.05	CHANGED	sESTDE...............D-oLP...................ssss+s+h..hupKAKEVLSS.............................................................pssshRPPhLGTW.phDsKPFuIIDGLST+SL..................hs..ppppp.p-............p..........................ptst.sss.pppssssus-sssLs.....................LsELL.............................................Nh.............SELDD-	....sESTDE...............D-sLP...................sPss+pKp..hupKA+El..lSS.............................................................pslG.l+PPKLGoW..ph-s.KPFoIIDGLSTKSL........................ash.pptpp.pp................................................pppspss...pppppssuspsspLs.....................LsELL................................................Nh..........SEL-s.....................................................................................	0	6	18	30
+10213	PF10381	Autophagy_Cterm		Autophagocytosis associated protein C-terminal	Finn RD, Wood V, Coggill PC	anon	Pfam-B_10019 (release 7.3)	Domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The small C-terminal domain is likely to be a distinct binding region for the stability of the autophagosome complex [2]. It carries a highly characteristic conserved FLKF sequence motif.	20.10	20.10	21.30	22.70	15.80	19.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.65	0.72	-6.81	0.72	-4.82	20	317	2009-01-15 18:05:59	2007-09-18 14:32:30	4	5	286	1	226	312	3	24.90	65	7.80	CHANGED	Vc.YLhlFLKFlsSVlPTIEaDhTh	...Vc.YLllFLKFlsSVlPTIEYDaTh..	0	80	125	186
+10214	PF10382	DUF2439		Protein of unknown function (DUF2439)	Mistry J, Wood V	anon	Pfam-B_19050 (release 22.0)	Family	Proteins in this family have been implicated in telomere maintenance in Saccharomyces cerevisiae [1] and in meiotic chromosome segregation in Schizosaccharomyces pombe [2]	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.89	0.72	-3.77	22	223	2009-01-15 18:05:59	2007-09-19 16:23:01	4	16	177	0	160	201	0	81.80	29	12.84	CHANGED	VtE.apCLYTsplppKpKpWpDGhL+aa..phNs+l.Lasp.ssshlsstahppp.......p.hs.spEhcl.p.thLlpl...s-hhpphpp-ls	............c.apsLYT.cph.p+.Kp.KpW.p.DGhL+hp....phsp+hhLY..D-...pushlsshahpst..............................ttlpsGc-h.chpp..hLlpl...p-hht......................................................................	0	43	78	124
+10215	PF10383	Clr2		Transcription-silencing protein Clr2   	Wood V, Coggill P	anon	Wood V	Family	Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organisation at the cnt domain, the site of kinetochore assembly.	25.00	25.00	26.10	27.80	24.30	24.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.93	0.71	-4.18	13	79	2009-01-15 18:05:59	2007-09-19 16:32:14	4	4	73	0	63	83	0	132.90	27	19.30	CHANGED	lappGIFlGAEhLhVGDsVRL...........tsh.ht.t...psstssssDVMVI-....EIplclhpsssshpu.......pVRlsGclYTsscppA.h..p.sshs..sspP........hsh-EVhsphp.hlGMuuhucW.............apLhs.s........sslclopshVlGRhYE	....ahpGlFlGAEhlhlGDsVRL.............hsht..p.s...............ssts..pss-lhlIc....pIphchhs.sssshts..........slplhGclYshs.ppu.tt....s.....spP..................hh.cElhpphp.hl.....shtthupW............................athht.t.............psspls.splhGRhY......................................................	0	14	32	50
+10216	PF10384	Scm3		Centromere protein Scm3	Mistry J, Wood V	anon	Pfam-B_19394 (release 21.0)	Family	Scm3 is a centromere protein that has been shown in Saccharomyces cerevisiae to be required for G2/M progression and Cse4 localisation [1].  The C terminal region of Scm3 proteins is variable in size and sometimes consists of DNA binding motifs [2].	24.30	24.30	24.30	25.90	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.78	0.72	-4.48	35	154	2009-09-14 14:05:34	2007-09-19 17:11:47	4	9	141	3	104	165	0	57.60	34	9.22	CHANGED	pcltpt+ppucp+hKstacsIh-KYup.-.cs.uDEIDL...pTGc...IVhDNGHL+slpscp	............cltpt+ptucp+h+stappIh-KYsp....-s.u.DEIDL...pTGp...IlhDNGHlcphpsp.t..............	0	25	51	80
+10217	PF10385	RNA_pol_Rpb2_45		RNA polymerase beta subunit external 1 domain	Coggill PC	anon	Gene3D, pdb_2a6h	Domain	RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.04	0.72	-4.17	149	8806	2009-09-11 00:06:38	2007-09-21 14:13:17	4	34	7040	41	964	6923	2365	66.20	46	8.12	CHANGED	YR+V.....ps.............GpV...oc-lhYLoA.-EcpahIAQAss..sl..........-ccG.phh....s.-hVhsR.hpu..-h...hhssspcV-ahDVS	.....................YR+V......ts........................GhV....TDE.l..pYLoA.EEs.palIAQANu..sL..........D.-.c.G....pFs..........-.-hVssR..ppG.......Es................thhs...-cVDYMDVS...........	1	338	646	822
+10218	PF10386	DUF2441		Protein of unknown function (DUF2441)	Finn RD, Coggill PC	anon	Gene3D, pdb_2aua	Family	This is a family of highly conserved, predicted, proteins from Bacillus species. The structure forms a homo-dimer. The function is unknown.	25.00	25.00	25.00	26.60	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.70	0.71	-4.15	2	90	2009-01-15 18:05:59	2007-09-26 11:48:52	4	1	90	2	4	56	0	137.10	76	70.61	CHANGED	NTLaHFFFEREpLNusGcDuhQILpcHYpNpELHIpNENApVVMsYMDQTIRAhRETIVEMlRLQEaPpYPSRLSCLYAAKSYEDALKWKALFDSYNREVLQIVKLpVIGsSFEGDGNLLPKEDuIPFSQKhEQAREYWKG	.....................................NTLYHFFFE+EQLNusGEDuhpIlppHYKN-ELHINNENApVVMNYMDQTIRAlRETIVEMVRLQEaP-YPSRLSCLYAAKSYEDALKWKALFDSYNREVLQIVKLRVIGsS.FEGDGN.LLPKEDGI...PFSQKhE..QAREYWKG....	0	2	3	3
+10219	PF10387	DUF2442		Protein of unknown function (DUF2442)	Finn RD, Coggill PC, Bateman A	anon	Gene3D, pdb_2auw & Pfam-B_2245 (release 23.0)	Domain	This family of bacterial and fungal proteins has several members annotated as being putative molybdopterin-guanine dinucleotide biosynthesis protein A; however this could not be verified. Hence the function is not known.  This family also includes the DUF3532 that was found to be related and was merged into this family. Members of this family also fall into the NE0471 N-terminal domain-like superfamily, a family of proteins with a unique fold in SCOP:143880.	21.10	21.10	21.20	21.40	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.66	0.72	-3.96	153	848	2009-01-15 18:05:59	2007-09-26 12:29:25	4	11	504	5	290	765	94	71.90	20	66.29	CHANGED	shsVphtss.....plhlphsD....Gcphtlsls.h...hppushppl..........pphplt.tstulpWs........shD.DluscuLhtstts	.................hpVphhpsh.plhlphs-....Gpphhhshp.hh......ppsshppL.........h...ppspl...p.st..slpWs..............s.s.hDlsspsLht....t.................	0	92	202	258
+10220	PF10388	YkuI_C		EAL-domain associated signalling protein domain	Finn RD, Coggill PC	anon	Gene3D, pdb_2bas	Domain	In Bacillus species this highly conserved region of the YkuI protein lies immediately downstream of the EAL (diguanylate cyclase/phosphodiesterase domain 2) Pfam:PF00563 domain so that together they form a monomer which dimerises for its enzymatic action. The region contains three alpha helices and five beta strands and is the C-terminal half of the structure.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.13	0.71	-4.57	14	277	2012-10-01 23:40:40	2007-09-26 14:17:17	4	6	265	6	64	194	4	149.80	31	33.45	CHANGED	hl-cshhK-+Lpp-hcpFIpaE+KKLps.aphsEphppclpph.lsclK+spp.s.Ehlhpluptls-hsFRlYlCDc-GaQhosNhhK.psGpWhlps-ahtKNWSWRPYFLENIh+Mppcp+G..llSDLYoDIETGEhIRTaSYPls-phYLFlDlsYpaLaEp-uLh	......................................................................................hptaht.chpphtt.hph.tp.h.ppltph.lt....p.cpst.p......s..p....hl.....t.....h.sp.t.l..s......ps..s..h..R..IahssccGhQpoGNs..h+.....p......s.....upW.....hlp....s..paht+NWSWRPY..FlcsIh..c.h.+..pp+s..hlS-hYtDlpTsch....hhThS..hs...l...s..s.p.hLhl...Dl..............................................	0	24	43	52
+10221	PF10389	CoatB		Bacteriophage coat protein B 	Finn RD, Coggill PC	anon	Gene3D pdb_2ifo	Family	CoatB is a single filamentous bacteriophage alpha helix of approximately 44 residues. It is likely to assemble into a complex of 35 monomers in a Catherine-wheel like formation [1]. It is the major coat protein of the virion.	24.80	24.80	25.50	25.90	24.10	24.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.13	0.72	-4.10	6	39	2012-10-01 20:22:05	2007-09-26 17:16:45	4	1	34	1	11	37	4	46.50	34	62.44	CHANGED	AuuuGlDVu-VssAIpuAtusIuoIGuuVLsVlVul+VaKWlRRuh	.............usutuhDlssVsoulsuAtssluslGuAVLslhluItlaKalR+Ah..	0	1	4	9
+10222	PF10390	ELL		RNA polymerase II elongation factor ELL  	Wood V, Coggill P	anon	Wood V	Family	ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF [1]. Some members carry an Occludin domain Pfam:PF07303 just downstream. There is no S. cerevisiae member.	21.60	21.60	23.80	23.80	21.50	19.90	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.86	0.70	-5.18	19	307	2009-01-15 18:05:59	2007-09-27 14:12:00	4	7	103	2	164	239	0	244.00	31	44.81	CHANGED	pEstsYGLshuphsss..pholhaVKLT-oAl+AlppaQp.....p...sh+PsIpF.pGspG.................................................................hlpIPpsc.sss...................hppFsFhlSslup-sspG.SaDClpQhhtpsGsspLpsLGsIp-KlslpAosDSYpt....oRpphspsEE-p+s+soh.IKsssp.su++Vph..+ps...................................................................................ssshssssP...ppcpopPh...............................................................................p.sssh+pts............ssssppRshR-RllHLLAL+PY+KsEllhRLp+DGlspp-+psLsslLppVusls.p-ssasL+chhap-lQ.cDWPsYoEs-+phlcphLs+pLs	.........................................................................................................................................................................................................................................................................................................................p.......................phh.l+Ls-sshpshpthpt...............ps.ItF..pG.pG.................................................................hlplPtss....sp...............................p.FsFhlSsh.sp-tspG.oh-....s..lpQh....stpGttpLpsLGslp-+l.slpA..s.sDSYph.......s+pphspsEE-.p+..spss...h..IK..sss...h....s.c.psph...pp.s..........................................................................................ths..ssss...ppppspPh.......................................................................................................................................p.t.thpptt..............................sslppRshR.-RllHLLAL+sa..+K.s.ELlh.R..L.p+.-G....l..s.p..-+stlss...hLppV.uphs...t....ct........oa...sL+c.hap-lp.cDWPhYo.-.-pp.lcphh.p...t.........................................................................................................................................................................	0	38	49	91
+10223	PF10391	DNA_pol_lambd_f		Fingers domain of DNA polymerase lambda	Finn RD, Coggill PC	anon	Gene3D, pdb_2bcq	Domain	DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [1].	29.80	29.80	29.80	29.80	29.70	29.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.32	0.72	-4.41	58	544	2012-10-03 02:11:09	2007-09-27 16:59:55	4	29	240	212	323	547	116	52.00	38	9.68	CHANGED	lphFsslaGlGspsApcaap.pGhRTL-DL...cp.pt.pLoptQplGlcaY-Dhpp	......hphFsslaGlG...spoApcaap..pGhRoL-...Dl.............+p....ps..pL..opp..QplGlcaY-Dht........	0	92	151	228
+10224	PF10392	COG5		Golgi transport complex subunit 5	Wood V, Coggill PC	anon	Pfam-B_24958 (release 21.0)	Family	The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.	29.00	29.00	29.10	29.30	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.38	0.71	-4.19	16	280	2012-10-03 17:31:52	2007-10-01 16:23:45	4	6	245	0	199	280	3	126.10	26	20.85	CHANGED	-sFL-ssFsspsFuNslLh.............tspstssssLDlsoslc+lpaDlpElDp+lcphhssst.pLLsphsshpptpu.llsplcsslptLstSacRLcscVlpPaccAtplpssLp+lapTscLLRsshhaltLuppL	........................sFL.sssFssppassphlt.........................................................thslus.Ls+Lthslppl-pclcp.lsspttsL.Lspssshpphps.llptlpsplpsLptuhcRLcpcll-PapphpphpttLp+lptsscLLRpshRhLtLu++L.........	0	63	110	164
+10225	PF10393	Matrilin_ccoil		Trimeric coiled-coil oligomerisation domain of matrilin	Finn RD, Coggill PC	anon	Gene3D, pdb_1aq5	Domain	This short domain is a coiled coil structure and has a single cysteine residue at the start which is likely to form a di-sulfide bridge with a corresponding cysteine in an upstream EGF (Pfam:PF00008) domain thereby spanning a VWA (Pfam:PF00092) domain. All three domains can be associated together as in the cartilage matrix protein matrilin, where this domain is likely to be responsible for oligomerisation [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.09	0.72	-4.59	14	256	2009-01-15 18:05:59	2007-10-02 16:16:30	4	52	50	3	93	230	0	44.00	40	7.85	CHANGED	pls.pEDsCtCEulltFQppVpstlppLspKL-sVo+RLptLEp+lh	...........cDsCtCEulltFQspspu.tlp...p..LT.p....+.......L...tt...hopRlp.LEspl........	1	5	12	33
+10226	PF10394	Hat1_N		Histone acetyl transferase HAT1 N-terminus	Finn RD, Coggil PC	anon	Gene3D, pdb_1bob	Domain	This domain is the N-terminal half of the structure of histone acetyl transferase HAT1. It is often found in association with the C-terminal part of the GNAT Acetyltransf_1 (Pfam:PF00583) domain. It seems to be motifs C and D of the structure. Histone acetyltransferases (HATs) catalyse the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. HATs are involved in transcription since histones tend to be hyper-acetylated in actively transcribed regions of chromatin, whereas in transcriptionally silent regions histones are hypo-acetylated [1].	21.40	21.40	21.60	21.70	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.45	0.71	-4.17	45	314	2009-01-15 18:05:59	2007-10-02 16:40:42	4	9	267	3	220	310	2	156.60	28	35.93	CHANGED	sssuN-AlplplV..............................p....sstphp..t.......ss.FpPpFTa.IFG-sE..pIFGYcsLpIpLhasusohcsalplpYspK.......sshphsD....lpppLtc..hlPp......................s.hhpscp.....-Fhpsl..pp......................cpcs.ac.PsGp..hl.csa.......................s..ss....tp...ac......................................................................Iapsslts.ss...hpch+pRlQhFlhhFIE	........................ssuN-AlplpLV......................................p.........sspshtpt.............tsFpPpaoaplFG-sE..pIFGY+s..LpIpLhasAsshpshlplp........YspK......th..sshpssD....lpsplpp..hlPt...............................s..hhpsts.....-Fhptl....c..........................................cpts...Fp..P...Gp..ll..csa...................................s..ss......tp.............ap................................................................................Ia+s..shs..s...sshpchapRlQhFlhhFIE...........................................................	0	74	119	183
+10227	PF10395	Utp8		Utp8 family	Mistry J, Wood V	anon	Pfam-B_24590 (release 22.0)	Family	Utp8 is an essential component of the nuclear tRNA export machinery in Saccharomyces cerevisiae.  It is a tRNA binding protein that acts at a step between tRNA maturation /aminoacylation, and translocation of the tRNA across the nuclear pore complex [1].	21.00	21.00	21.40	21.60	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.20	0.70	-6.22	10	40	2009-01-15 18:05:59	2007-10-03 11:45:37	4	2	40	0	29	41	0	652.60	33	98.20	CHANGED	MPSlopPFhLusLP+luSLsshcptsssspsus.s.p.cssplslGIStSoISpYlIsPTPKLlasaPlPsTsIVsuhsVhshss..............................ppclashGLosp+Kp+hLplppc...................stsssussEssspacl.Klcc+llslKlh..scsplIlVlhcsGhlchaca...............pLpht+sh..cl.Yo..pFVpchc.pstp-allllss.pscK..lsYKLlpL....sscssulhEL.sSsIlEshslssophsYphGpLYpL..ssscIplYolPsh.plppoIplP.hlscp....-hlSlpslusNRVLLossNKIYLlDlhasulLsph-.....op.pshQlLhsuVlsspspupso+.ThAlslshKNGsN.sotLcVINIsVGosoLc-.uLGKShppsss.....ppsthLcsLFs-csh...........spsElsslphhclLp-Lp..pppclpp............FDsIhhphLK.cK..........................Ea.sEsDRhl.DspFlsplL-LIFs.......pFtss-..a....P.+oLhYLLTHPLFPhs+T+GLLsphc..spscLhKQAIVTCPNLPLc-LLppLFo.pNsE.lhhDlshRlLp-ao+c-IppshK+L.....uplDlpshlshllpssss............phapLlsllIDusGLFuh-t-sl-cLsuhI-scVplhspNsphlsLl-phhLpspstspsupppps.....................................ccsspslstp...YoVEhL-l	.....................................................PsLopsatlssLP+lssLs..ph.ss.....h.sus...p.sospIslGlStS.ISpYIlpPTPKLlasaslssTslVsshslhphps................................chashGLpspKp.phL.ltpp.....................st..ssssphhsphcl.K...h.cs+lhslKh....tpsphlhslhpNGhlphaca..................plphhpsh..clsYs..palpphp......t.tpcalhllss..pss+..lsa+Llpl......pssslhEl.sp.hhcshshpsuphsYp..GpLYpL.....spt..pI.haSlPph.plppsIpls.hlsc....pcllShpslusNRlLLossNpIYLLslhasSlLophc........ho+s+shplLpssVlss....c.pS.p..so+.ThAlslshKNtsN.sopLclINlDVGoNs.Lp-.uLGKShp.....ssss...............sps.lLcsLFs-cshs..........tss-lt.pl...chlccLp..pspDlsp............F-sIhhthLK.+c..........................Ea.s-pDRhl.D.sFlspVlcLIFs.......pFp.ss-...a......P.+TLTaLLTHPLFPhphTcsLLphLc..spPRLhKQAIVTCPNLPlp-LLppLhs......lcNpE.......l...hhDlshRllp-Fop-pIppphKcL..................splDlpshIphllshsps............phapLLslllDuhGL...Fs.h....ctshlcpLsphI-ppVchhppNophhsLl-pthhpp.thtpppscppss.....................................ppps.........hYolEhL-l...................................................................................................	0	5	16	27
+10228	PF10396	TrmE_N		GTP-binding protein TrmE N-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1xzp	Family	This family represents the shorter, B, chain of the homo-dimeric structure which is a guanine nucleotide-binding protein that binds and hydrolyses GTP.  TrmE is homologous to the tetrahydrofolate-binding domain of N,N-dimethylglycine oxidase and indeed binds formyl-tetrahydrofolate. TrmE actively participates in the formylation reaction of uridine and regulates the ensuing hydrogenation reaction of a Schiff's base intermediate.  This B chain is the N-terminal portion of the protein consisting of five beta-strands and three alpha helices and is necessary for mediating dimer formation within the protein [1].	21.60	21.60	21.60	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.38	0.71	-4.11	270	4354	2012-10-01 23:12:28	2007-10-03 14:31:21	4	10	4206	9	1027	3258	2398	116.40	44	25.73	CHANGED	TIsAlATs..sG.pGuluIlRlS.....Gspuhplspp...lh.............sp.....t.p.........s...+pspa...s..plhD....ts.........sp.......hlD-s.l.llhFhuP........pSFTGEDVlElpsHGGhsllptlLp.tllph..............G..............sRhAcPGEFTcRAFLNG+	..........................................TIsAluTs...G...cGuluIlRlS.....Gs..p.A...h.p.l...u.pplh...........................sc.....p...............s..+phpY..s...plhD............ts....................................sp.................llD..c.s..l...lhh.ah.u..P.........pSF.TG..EDllElpsHGG.lllstlLphllph...............G...............................................sRhA..cPGEFTcR.....AFLNG+.......................	0	354	652	860
+10229	PF10397	ADSL_C		Adenylosuccinate lyase C-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1c3c	Domain	This is the C-terminal seven alpha helices of the structure whose full length represents the enzyme adenylosuccinate lyase. This sequence lies C-terminal to the conserved motif necessary for beta-elimination reactions [1], Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole-carboxamide ribotide into aminoimidazole-carboxamide ribotide, the eighth step of the de novo pathway, and the formation of adenosine monophosphate (AMP) from adenylosuccinate, the second step in the conversion of inosine monophosphate into AMP [2].	22.90	22.90	22.90	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.43	0.72	-3.97	148	3649	2009-01-15 18:05:59	2007-10-03 14:33:22	4	11	3192	22	1012	2751	1563	82.20	29	18.48	CHANGED	tGllhopplhhsLs.p.pGluRppAaclVpcsuhpuhp......p.sps.........ht....-hLt...pDsplt...thlopc-.l.cplh.DPptalspssplhc+lh	..................................GLlhop+VhhsLl..c..pG.......hsRE.cAa-lVptpuhpuhc.......................................p..pss............hh....phLt.....sD.scls.......t.h.Lo.p......--.l..c.chh.....Dsp.haht....pssslhcRh..................................	0	333	643	850
+10230	PF10398	DUF2443		Protein of unknown function (DUF2443)	Finn RD, Coggill PC	anon	Gene3D, pdb_1zke	Family	This is a small family of highly conserved proteins from bacteria, in particular Helicobacter species, The structure is a bundle of alpha helices. The function is not known.	25.00	25.00	31.70	51.50	22.30	21.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.61	0.72	-4.18	3	57	2009-01-15 18:05:59	2007-10-03 16:39:50	4	1	56	6	5	26	0	77.80	81	99.60	CHANGED	MFEKIDcIL+sIEDSR-EIEILLNlAKISLlDYIMIKRGSMDMPEHLshshLsQIDEEVEKLKEpI-ALNKIKKELLlF	MFEKIRKILA-IEDSQNEIEMLLKLANLSLGDFIEIKRGSMDMPKGVNEAFFTQLSEEVERLKELINALNKIKKGLLVF.....	0	2	4	5
+10231	PF10399	UCR_Fe-S_N		Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal	Finn RD, Coggill PC, Bateman A	anon	Gene3D, pdb_1zrt	Motif	This is the N-terminal region of the E or R chain, Ubiquitinol-cytochrome C reductase Fe-S subunit, of the hetero-hexameric cytochrome bc1 complex. This region is a TAT-signal region. The cytochrome bc1 complex is an oligomeric membrane protein complex that is a component of respiratory and photosynthetic electron transfer chains.\	  The enzyme couples the transfer of electrons from ubiquinol to cytochrome c with the the generation of a protein gradient across the membrane [1]. The motif is also associated with Rieske (Pfam:PF00355), UCR_TM (Pfam:PF02921) and Ubiq-Cytc-red_N (Pfam:PF09165).	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.99	0.72	-4.79	49	936	2012-10-02 00:19:25	2007-10-03 17:10:36	4	4	874	26	297	706	1269	39.70	41	20.61	CHANGED	hssspsspsoRRDFLalATuusuuVGuuussWPhIsQMNPs	...........ppshsssRRcFLhhA.TussGuVGususAh.PFlsShsPS........	0	73	167	224
+10232	PF10400	Vir_act_alpha_C		Virulence activator alpha C-term	Finn RD, Coggill PC	anon	Gene3D, pdb_1yg2	Family	This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (Pfam:PF03551), which is a transcriptional regulator.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.74	0.72	-3.62	37	838	2009-09-11 09:27:19	2007-10-03 17:40:19	4	3	630	1	235	647	7	88.30	21	48.18	CHANGED	sslR-EhLlKlhusshhssssltsplpcphphppp+LspYcclc.pchhss...tpth.stpphhpaLsLctGlphEpthlcWs-cslthLsthp	............hRD-hhlKlhhs...sh.hs.s.sshht.lp...cphpt...ppcplpp.app...hc..pphass..............tt...sppphhphLsLct..ulthcpshlpWh-cslttLp...t.................................................	0	73	158	207
+10233	PF10401	IRF-3		Interferon-regulatory factor 3	Finn RD, Coggill PC	anon	Gene3D, pdb_1zoq	Family	This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein.  These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).\	  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.	20.80	20.80	20.80	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.92	0.71	-4.70	43	649	2012-10-01 21:55:46	2007-10-04 10:54:49	4	8	78	11	242	858	0	168.80	31	40.48	CHANGED	hspLclshaYpGchVt.phplssspGsRlhh....tsssststhht.............shpplhFPssst..l.....sppQpphsccLLssl-+GllLphssp.ulaupRLsps+VaWsusss.tss.....tPs.pLc+s.ppsplFshppFlp........................-Ltpa.p.pstssPp.a.plhLCFG-chss...pstpc+LIhVpl.PhhsRhlhEhsp	..............................................hpLcl.ph.hY+Gc..Vt..phslsssp.GCRlhh............tss.stst...s.................shppVt..F..Psspt...l............sp....pQ....pp....hspcLL.stl-+GllLthssp...u......la.u.pRL..Cps+VaWsuspsssts..........tPs...hlpRp.ppsclFshp.p.Flp.........................-Lhta...p.....pttt......P....p.....a.plhLCFGE-aPs.t.pshp++LIhV.pl..shhs+.lhp.h...........................................................................	0	25	43	115
+10235	PF10403	BHD_1		Rad4 beta-hairpin domain 1	Bateman A	anon	Bateman A	Domain	This short domain is found in the Rad4 protein. This domain binds to DNA [1].	20.60	20.60	20.60	21.60	20.50	17.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.81	0.72	-4.45	56	421	2009-01-15 18:05:59	2007-10-05 13:00:34	4	18	274	3	311	451	1	57.10	35	6.66	CHANGED	phscshPcol...........pshKsHPhalL-+pL++pEslhP..sspslGhhps.t...................EsVYtRssVh	.....h..pcshPpsl...........psaK..sHPl........YsLcRaLp+pEslhP...ssp....lGhhps.....................EsVYpRssV.......................	0	91	161	258
+10236	PF10404	BHD_2		Rad4 beta-hairpin domain 2	Bateman A	anon	Bateman A	Domain	This short domain is found in the Rad4 protein. This domain binds to DNA [1].	21.30	21.30	21.40	22.70	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.27	0.72	-3.66	62	397	2009-01-15 18:05:59	2007-10-05 13:01:31	4	16	257	3	291	426	3	61.20	34	7.04	CHANGED	L+St-pWh+p..GRslKhsEp.Ph...KhVpt.t.......p........p.tpp...............................phsLYuhaQT.......-.ahPP	......l+St-sWh+p..GR.sl+..hGE.....p..Ph...KhVpt.pst.....ttp.........pttppt.............................................................thsLYuhaQT.......-.YhPP.............	0	80	150	241
+10237	PF10405	BHD_3		Rad4 beta-hairpin domain 3	Bateman A	anon	Bateman A	Domain	This short domain is found in the Rad4 protein. This domain binds to DNA [1].	20.60	20.60	20.70	22.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.52	0.72	-4.27	34	411	2009-01-15 18:05:59	2007-10-05 13:03:48	4	17	264	3	308	438	6	76.00	38	8.82	CHANGED	lP+NsaGNl-latssMlPhGsVHlp......hsslt+lA+...........tLsIDaA.AVTGFcF......+stpspPVhsGlVVscEap-tlhpsa	....lP+NpaGNl-l..a..hss.MlPtGsVHlp............................hss...ht+lA+..............................pL.sID..aApAVsGF-F...............+sttu..hPlhpGlVVscEhc-hlhpsh................	0	91	162	258
+10238	PF10406	TAF8_C		Transcription factor TFIID complex subunit 8 C-term 	Wood V, Coggill P	anon	Wood V	Domain	This is the C-terminal, Delta, part of the TAF8 protein [1]. The N-terminal is generally the histone fold domain, Bromo_TP (Pfam:PF07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery [2].	19.10	19.10	19.70	19.30	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.42	0.72	-3.91	25	316	2009-01-15 18:05:59	2007-10-08 10:18:23	4	7	242	0	219	302	0	49.80	39	13.82	CHANGED	sYIPsa..LPsFPscHTYppTPhappslo.D.+plRc+hsc-uRhsE+uLh+Lh	.........aIPsa..hPsFPssHTYhp.TPha..p..c.ho.....DhptlR..c....+tspppRpsEcALp+h............................	0	60	110	174
+10239	PF10407	Cytokin_check_N		Cdc14 phosphatase binding protein N-terminus   	Wood V, Coggill P	anon	Wood V, Pfam-B_23062 (release 22.0)	Family	Cytokinesis in yeasts involves a family of proteins whose essential function is to bind Cdc14-family phosphatase and prevent this from being sequestered and inhibited in the nucleolus. This is the highly conserved N-terminus of a family of proteins which act as cytokinesis checkpoint controls by allowing cells to cope with cytokinesis defects. These proteins are required for rDNA silencing and mini-chromosome maintenance [1].	21.20	21.20	21.20	21.90	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.35	0.72	-4.36	16	70	2009-09-11 05:31:51	2007-10-08 14:49:30	4	2	54	0	49	73	0	73.10	37	7.39	CHANGED	ppsKKFLah.TcsssoLhpLs-EIhs+hpKlYPs.p..clcIhoLQDpstCDLDP-FlVcDVFs.ssshVRVILcsch	..........s.h+KFLah.Tcs.ssoLhpLupEIls+acKlYPshp...sl-.IloLQDp..s..u..CDLDs-FlVcDVFs.ssshl+Vllcs-.h...............	0	15	29	44
+10240	PF10408	Ufd2P_core		Ubiquitin elongating factor core	Wood V, Coggill PC	anon	Wood V, Pfam-B_4085 (release 22.0)	Family	This is the most conserved part of the core region of Ufd2P ubiquitin elongating factor or E4, running from helix alpha-11 to alpha-38. It consists of 31 helices of variable length connected by loops of variable size forming a compact unit; the helical packing pattern of the compact unit consists of five structural repeats that resemble tandem Armadillo (ARM) repeats. This domain is involved in ubiquitination as it binds Cdc48p and escorts ubiquitinated proteins from Cdc48p to the proteasome for degradation. The core is structurally similar to the nuclear transporter protein importin-alpha. The core is associated with the U-box at the C-terminus, Pfam:PF04564, which has ligase activity.	20.40	20.40	21.50	21.20	19.40	20.10	hmmbuild  -o /dev/null HMM SEED	629	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-12.77	0.70	-6.28	50	532	2009-01-15 18:05:59	2007-10-09 16:35:59	4	19	290	5	355	518	10	538.70	29	57.82	CHANGED	LGslhslSshs............sphspta......h..tsstptsppplpsthpslptphpshhppLapllppll+suspsR..pphLpahupl..lphNptRpph..........................phc.ppluS..-GFhhNlshlLl+LspPhhc............hsKlc+IDssY..................................hhp..sshlcl.......p-ETclpus.ccscphhspptp..............................................pFlo-hFFLThpshahGhtshhpchpcltpplpchpcphpphptp...............p..htphppplcthhspphshcsh.lhcsshhppshpFhshsstalh+lh...........s.tp.hsp.pthphP......h.tt.........................................................................s.........................aphlPEahl-slhsah...hahhph.......sshhhst.phcphlphslhhhpssp.hlcNPaL+u+llclLhhhh.sht..tppthh.s........lhpsppls.....pcpLlhuLlchYl-lEpTGsp....sQFY-KFNhRapIstlhcplW.ppsta+p.pltc.scs...........................................................................s.s.hFlRFlshllNDssa.LLDEulspLpcI+ch..ppphpstsphtsh......................................sppp...cpc....................................................pppplpptcpps+ohhtLupcolphhphhT..pplscsFh.psEll-RlAuMLNYsLptLsGPKsps.L.KV+ssccYs..FcP+plLsplsclYlNLs..........ppcp...FltAVupDGRSas.phFpcAhpllpchs.lhstp.lpphpphspclcc	............................................................LGshhp.hSsh.................stsspta...............a......ss.t.s.tph.ts.ttslp.hhp.hppplhplh.ppl..l....hs...sp...sR....pthLp.ahuth..lphNttRtth..........................php.p...h..huo....DuFhhNlhhlL.pLsp.h.................KltplcspY...................................hp..pttlph........pcETpl.ss.pt.p.thhtp...t...................................................pF.o-sFaLThtshahuhhs..hhpp....h..p.h..pplcchppt.hpphptpt..............................p.hhpphcpphcthhp.hhsh..csh..l.......h-...ph.ppshp.Fht.hhh.hll.plh.....................t............thphP...............Ls.t.............................................................................................................s...t.hthlP.Eahl-slsphh...hFlhph......................s..hh....t..t...hpp.hlthhlh.hhts.p....hl+NPaL+A+L.splL..hh...ht......pt.hh.p................................hhppp.hs.......tp.Lh.uL..hcha.s.-lEhTGsp..............spF..h-KFshRh.l..lhc.lW..ts..a+t..phhp.spp..........................t.....Fl+FlNhLhNDsha.LLDEu.....l.ptLtcI+ph..Qt.hpsp.tphtth......................................................................s.pt.....ppp.............................................................................cpppLtp.tp.s+.hhhLup-TlshhphhT..p..p..l..tpsFh..tPpls.p...........RluuMLNa.LppLsGPKpts.L.KVc..s...............p.cYs..FcP+pLlsplsslYlpL....................................sppp.........FhtAlupDtRSY..s.plFppshphlp.+h...s...h.....sst.l.tpaptlsp+hp..........................................................	0	132	197	291
+10241	PF10409	PTEN_C2		C2 domain of PTEN tumour-suppressor protein	Finn RD, Coggill PC	anon	Gene3D, pdb_1d5r	Family	This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding.  This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam:PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane [1].	25.50	25.50	25.50	25.80	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.88	0.71	-4.44	61	847	2012-10-10 12:23:49	2007-10-11 15:54:09	4	39	146	25	477	790	5	136.70	24	15.32	CHANGED	hsspslhlpplhl......psl...........P.h....p.ts.....ss.........cPhlplhptpphl.................t.phpthppt.............ptpphhhhhs.sl..l.p..GDlhlch.hppp........hhtcph.....hFphhFNTuFlp...................................................................................................................................sshLhhs+s-LDt.stcs...cpaspsFpVclhFsc	.............................................................................................psLhl+plhh.psl...........P.F...ptts................uC.............................cPhh.clh..ttpphl..............................................pst..hph.ht.ph....................................................................ptphhhh..h...h...s.....sl...hl.p...G....Dlh.lch.aHtp..p.........thpcph.............hFph.FpTsFlp.................................................................................................................................................................................................................sthLhhsKp-LDt.spc.....s.......cpasptFpVclhFt..................................................................................................	0	147	223	334
+10242	PF10410	DnaB_bind		DnaB-helicase binding domain of primase	Finn RD, Coggill PC	anon	Gene3D, pdb_1dd9	Domain	This domain is the C-terminal region three-helical domain of primase [1]. Primases synthesise short RNA strands on single-stranded DNA templates, thereby generating the hybrid duplexes required for the initiation of synthesis by DNA polymerases.  Primases are recruited to single-stranded DNA by helicases, and this domain is the region of the primase which binds DnaB-helicase [2]. It is associated with the Toprim domain (Pfam:PF01751) which is the central catalytic core.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.22	0.72	-3.98	185	3150	2009-01-15 18:05:59	2007-10-11 16:20:54	4	23	3048	9	677	2386	736	58.20	24	9.81	CHANGED	lh-Fhhcphtp..p.....h.sl..sss-u+sphlpp.shsllspls.sssh+phhhpcLucthulstppl	................L.pFhhpplht..p......h.sL...sss-G+sphhpt.shsllspls.stsh.RphhhppLupclGl..pt............................	0	208	432	568
+10243	PF10411	DsbC_N		Disulfide bond isomerase protein N-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1eej	Domain	This is the N-terminal domain of the disulfide bond isomerase DsbC. The whole molecule is V-shaped, where each arm is a DsbC monomer of two domains linked by a hinge; and the N-termini of each monomer join to form the dimer interface at the base of the V, so are vital for dimerisation [1]. DsbC is required for disulfide bond formation and functions as a disulfide bond isomerase during oxidative protein-folding in bacterial periplasm. It also has chaperone activity [2].	21.00	21.00	21.10	21.20	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.57	0.72	-4.71	144	1562	2009-01-15 18:05:59	2007-10-12 11:30:55	4	5	1318	12	304	941	348	55.30	33	22.65	CHANGED	lp..ppLp......phh..shplp..slpsoP...lsG.LaEVhs..ss...s......llYsstcG.callt.Gplh..-hpspp	....................lppsLt......ch....sl.p.ss..sIpsoP...lsG...hhpVho...su....s.......llYsos..DG....+allp.G.s.la..Dlssp.t.......	0	60	159	243
+10244	PF10412	TrwB_AAD_bind		Type IV secretion-system coupling protein DNA-binding domain	Finn RD, Coggill PC	anon	Gene3D, pdb_1e9r	Domain	The plasmid conjugative coupling protein TrwB forms hexamers from six structurally very similar protomers [1]. This hexamer contains a central channel running from the cytosolic pole (made up by the AADs) to the membrane pole ending at the transmembrane pore shaped by 12 transmembrane helices, rendering an overall mushroom-like structure. The TrwB_AAD (all-alpha domain) domain appears to be the DNA-binding domain of the structure. TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein, is the structural prototype for the type IV secretion system coupling proteins, a family of proteins essential for macromolecular transport between cells and export [2].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.04	0.70	-5.84	37	675	2012-10-05 12:31:09	2007-10-12 13:00:04	4	14	429	36	140	6042	663	312.90	31	53.44	CHANGED	shpluulPh.shpsEtpHhhlsGosGoGKoshlpcllsphRtR........G-RAllaDhsGsFhppFac..........ssp.DllLNPhDsRsssWshasEsps.hDacshApullP..t..ssss-sFWspuARtlFspssh+L.tpp..spposppLhctlhssslcpLcphLtsT.usslhutp..sp+.sstSl+uslsshlcslphLsstt..........ssFSIR-Wlpssp......suhLFlosptsptssl+PLlohWlslAhpslhu..hst......spc..+R.lWahhDELsuLp+LssLtpsLscuRKaGGshVlGlQuhuQLcclYGpc.tApolhuhhsT+lhhpss..sscsAchhuc..lG..cpElcchpEshSaGtss.hRDGs...........ohsppcpt...c.lVhso-Ihs.LssLpu.....alphssshPls+lplp	.........................................................................................................................................................................................................................s...hsslsh....hp.t.E.......pp.h.hlhGos.GsGK..o..p..h..l..p....p..l...h....p.......h..h...p..+....................G..c..h..s...l..l..a..D..........p......s.....p.........a........h......p......p....a..a...p........................................t........D.....h.....l.....l........N...P...h.....D......t....R..........s.............t.....Ws.........a......p........-....h........h........p.........................-..........h..........p....p.......h..........u.p....sl...ls...............tst....tcsaW.tu......u....ct..lh........s.............p....h............h.....h.....h.h....t.....p...p.....................p..........t..........s..................t.........p........l............h...p.........h........h............h................t.........................p............h...........c..............p............l..........p....p.....h.....l........t........s.........o....................s...............t...........s.......h.........h.p....tp..................hp+.....s...s....h........S....l.....p.....u........s.......l....s..s...h.....l.......p......s.h...p.....h....ltt.......................................t.F.o....l...+....c...W....hps.t................tuhLF.l...o........p.....t.....p...p.....c....s.....s....l....p.P....l.l....u....h....h....l....s....h....s....h...p....t.l.hs........hs.................................sp...p.......p+.....l....a....h.h..h.DE.ls........o....L....t..+.........l......s..p....l........ph..l....s..p.uR.......caG.........ssh.l.hG.h.Qsh.s.Q..L.....c.....c.....h....Y....G..c.p...h.A....t....s....l...h.s....h.h...s.oph..h.h..p.ss.....s.t...p...hA.chhut....l.G.....c..p..-...h.......p...h.......p.....c...p....h......o.h....u....t..s...................t.s...u.s.........................sh.sp..p......ph........p....l..l.......sc.l..p.Lsshps.....alhhst....................................................................................................................................................................................	0	27	81	120
+10245	PF10413	Rhodopsin_N		Amino terminal of the G-protein receptor rhodopsin	Finn RD, Coggill PC	anon	Gene3D, pdb_1edx	Domain	Rhodopsin is the archetypal G-protein-coupled receptor. Such receptors participate in virtually all physiological processes, as signalling molecules. They utilise heterotrimeric guanosine triphosphate (GTP)-binding proteins to transduce extracellular signals to intracellular events.  Rhodopsin is important because of the pivotal role it plays in visual signal transduction. Rhodopsin is a dimeric transmembrane protein and its intradiskal surface consists of this amino terminal domain and three loops connecting six of the seven transmembrane helices. The N-terminus is a compact domain of alpha-helical regions with breaks and bends at proline residues outside the membrane [1]. The transmembrane part of rhodopsin is represented by 7tm_1 (Pfam:PF00001). The N-terminal domain is extracellular is and is necessary for successful dimerisation and molecular stability [2].	21.10	21.10	21.40	21.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.73	0.72	-4.28	17	2285	2009-01-15 18:05:59	2007-10-12 14:21:53	4	2	1603	37	51	1764	0	30.00	80	15.25	CHANGED	NGTEGsNFYlPMSN+TGlVRSPaEYPQYYLA-Paha	...............NFYlPMSN+TGVVRSP..FEYPQYYLA-PWpY...	0	1	10	28
+10246	PF10414	CysG_dimeriser		Sirohaem synthase dimerisation region	Finn RD, Coggill PC	anon	Gene3D, pdb_1pjq	Domain	Bacterial sulfur metabolism depends on the iron-containing porphinoid sirohaem. CysG, S-adenosyl-L-methionine (SAM)-dependent bis-methyltransferase, dehydrogenase and ferrochelatase, synthesises sirohaem from uroporphyrinogen III via reactions which encompass two branchpoint intermediates in tetrapyrrole biosynthesis, diverting flux first from protoporphyrin IX biosynthesis and then from cobalamin (vitamin B12) biosynthesis. CysG is a dimer of two structurally similar protomers held together asymmetrically through a number of salt-bridges across complementary residues in the CysG_dimeriser region to produce a series of active sites, accounting for CysG's multifunctionality, catalysing four diverse reactions: two SAM-dependent methylations, NAD+-dependent tetrapyrrole dehydrogenation and metal chelation. The CysG_dimeriser region holding the two protomers together is of 74 residues [1].	20.40	20.40	20.40	20.40	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.93	0.72	-4.49	132	1426	2009-01-15 18:05:59	2007-10-12 16:12:34	4	8	1263	6	269	987	131	59.40	36	13.80	CHANGED	tslGpLAshuuphRscV+pplsshstRRpFWEchh.pG.huptlhsGppppAcpthpptls	...........pLGplAchAuphRscVKpphs.shspRR+.FWE+hF.sspl..Aptltsscpptsppthcphl........................	0	54	139	201
+10247	PF10415	FumaraseC_C		Fumarase C C-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1fup	Domain	Fumarase C catalyses the stereo-specific interconversion of fumarate to L-malate as part of the Kreb's cycle. The full-length protein forms a tetramer with visible globular shape. FumaraseC_C is the C-terminal 65 residues referred to as domain 3. The core of the molecule consists of a bundle of 20 alpha-helices from the five-helix bundle of domain 2. The projections from the core of the tetramer are generated from domains 1 and 3 of each subunit [1]. FumaraseC_C does not appear to be part of either the active site or the activation site but is helical in structure forming a little bundle.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.29	0.72	-3.90	258	5840	2009-01-15 18:05:59	2007-10-12 16:51:58	4	10	3710	79	1358	4033	1826	55.00	43	11.79	CHANGED	LVTALNPhIGY-pAAcIAKpAhcpGpol+-ssl.chGhl.......oc-phDcllcPppMspP	................lVTALNPaI.GY-pAAcIAKpAtc.pGpol+Essl.ch.Gh.L.........oc-chDchl.cPppMhtP.......................	0	415	827	1129
+10248	PF10416	IBD		Transcription-initiator DNA-binding domain IBD	Finn RD, Coggill PC	anon	Gene3D, pdb_1pp8	Domain	In Trichomonas vaginalis, thought to be the earliest extant eukaryote, the sole initiator element for control of the start of transcription is Inr, and this is recognised by the initiator binding protein IBP39. IBP39 contains an N-terminal Inr binding domain, IBD, connected via a flexible, proteolytically sensitive, linker (residues 127-145) to a C-terminal domain. The IBD structure reveals a winged-helix-wing conformation with each element binding to DNA, the central helix-turn-helix contributing the majority of the specificity-determining contacts with the Inr core motif TCAPy(T/A). The binding of IBP39 to the Inr directly recruits RNA polymerase II and in this way initiates transcription [1].	25.00	25.00	25.00	26.90	24.80	23.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.39	0.71	-4.34	94	107	2009-01-15 18:05:59	2007-10-12 17:53:28	4	2	1	7	107	109	0	122.10	22	48.18	CHANGED	ppD.pp.pahpLcphlss..p+pt+.............spphpsFsptLptlhpast+sss.p..RshlsGltWhsss...lslNscpLphLls+sKSo.....INGshpphGatth..t....tt.h...hs....hhps..shsph+.pWolRphss	...............D..pa.pLpphlss..p+pt+.............spphpsFsptLptlhpash+sss.p..RshlsGltWhsss...lslNscpLphLls+sKSo.....INGshpphGatth.tptp..tp.lhthhs.....htts..t.+.pWolR....s.....................................	0	107	107	107
+10249	PF10417	1-cysPrx_C		C-terminal domain of 1-Cys peroxiredoxin	Finn RD, Coggill PC	anon	Gene3D, pdb_1prx	Domain	This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [1]. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine, upstream of this domain; and glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulfide to the sulfhydryl and consequent activation of the enzyme [2].  The domain is associated with family AhpC-TSA, Pfam:PF00578, which carries the catalytic cysteine.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.89	0.72	-4.30	86	5521	2009-01-15 18:05:59	2007-10-15 10:44:00	4	14	3627	357	1733	3878	622	35.40	38	17.34	CHANGED	ALQhs-cp.s..ssPAsW.ps..........Gccsl...ssotc..u..hpcahps	.....AhQasppH..G-..VCPAsW.ct...........Gccsl...p.s.o.-............h......................	0	559	995	1407
+10250	PF10418	DHODB_Fe-S_bind		Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	Finn RD, Coggill PC	anon	Gene3D, pdb_1ep3	Domain	Lactococcus lactis is one of the few organisms with two dihydroorotate dehydrogenases, DHODs, A and B [1]. The B enzyme is a prototype for DHODs in Gram-positive bacteria that use NAD+ as the second substrate. DHODB is a hetero-tetramer composed of a central homodimer of PyrDB subunits resembling the DHODA structure and two PyrK subunits along with three different cofactors: FMN, FAD, and a [2Fe-2S] cluster. The [2Fe-2S] iron-sulfur cluster binds to this C-terminal domain of the PyrK subunit, which is at the interface between the flavin and NAD binding domains and contains three beta-strands. The four cysteine residues at the N-terminal part of this domain are the ones that bind, in pairs, to the iron-sulfur cluster. The conformation of the whole molecule means that the iron-sulfur cluster is localised in a well-ordered part of this domain close to the FAD binding site [2]. The FAD and and NAD binding domains are FAD_binding_6, Pfam:PF00970 and NAD_binding_1, Pfam:PF00175.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.62	0.72	-4.46	180	2835	2012-10-02 17:47:23	2007-10-15 12:37:55	4	37	1790	3	745	2221	217	38.60	43	13.13	CHANGED	EphMsCGlGhChuCs..lpst..........hpl..CpDGPVFsspclt	.....EppMs.C.GhGtChuCt..lpsstt...................hhV..ChDGPVFssppl........	0	318	533	651
+10251	PF10419	TFIIIC_sub6	TFIIIC_subunit;	TFIIIC subunit	Mistry J, Wood V	anon	Pfam-B_14433 (release 21.0)	Family	This is a family of proteins subunits of TFIIIC [1].  TFIIIC in yeast and humans is required for transcription of tRNA and 5 S RNA genes by RNA polymerase III.  Yeast members of this family are fused to phosphoglycerate mutase domain.	20.80	20.80	21.10	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.25	0.72	-4.49	25	235	2009-11-13 15:40:22	2007-10-15 13:05:59	4	6	207	0	162	231	0	34.40	35	13.12	CHANGED	lplhGL-ocpPllplsspl.apGsWcchlGT-lhFs	....hpllGl-ocpPllplsspl.FpGpac.-slGTplhFp.....	1	46	78	128
+10252	PF10420	IL12p40_C		Cytokine interleukin-12p40 C-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1f42	Domain	IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms [1]. This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40 [2]. The domain is often associated with family fn3, Pfam:PF00041.	25.00	25.00	30.30	29.20	21.20	22.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.07	0.72	-3.88	21	132	2009-01-15 18:05:59	2007-10-15 14:05:34	4	6	63	8	36	104	0	87.30	42	29.28	CHANGED	scsaLcCpApNYuG..cFpCuWhht..pssh.hhpl+upR.....................................sSsssptVoCuhs................pchulpCp.--stCPhAEEotPIplslcstpc	......KsFL+CEA+NYSG..cFTC.Whss.hsssl..pFsl+..usR.....................................sSsss...psVTCusssh..........ppp.pcYolpCQ.-cssCPhAEEshPIclsl-shp......................	0	1	6	15
+10253	PF10421	OAS1_C		2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus 	Finn RD, Coggill PC	anon	Gene3D, pdb_1px5	Domain	This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end [1]. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesise 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication [2]. This domain is often associated with NTP_transf_2 Pfam:PF01909.	19.90	19.90	19.90	22.40	19.00	19.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.44	0.71	-4.81	49	511	2009-01-15 18:05:59	2007-10-15 16:12:05	4	20	58	2	142	448	0	173.60	46	48.00	CHANGED	sscPs.splYspLIcpps..t..ptGEFSsCFTELQ+sFlcpRPsKLKsLIRLVKHWYppCpc+......htssLPPpYALELLTlYAWEpG.sspspFshApGFRTVL-L...ltcYppLCIYW....Th.YsFccphlppaLppQLc+sRPVILDPADPTsNVusu.sh.sWclLAcEAptWLppsChpststssVssWcV.sth	.................................s..pPs.splYspLIptts......ptGEFSsCFoELQ+sFlp.pR....P.sKLKsLIRLVKHWYppspcp................t....ssLPPpYAL.ELLTlYA...WEpG.st..pspF...shApGF.R.TVL.-L.........l.ppYppL.....CIYW.....Th.YsFcs.hlppaLppQLp.......+s.......RPlILDPADPTtNluts.s...WchLApEAtthh.ptsChhptptssltsWpV...h....................................	0	29	35	37
+10254	PF10422	LRS4		Monopolin complex subunit LRS4	Mistry J, Wood V	anon	Pfam-B_63451 (release 22.0)	Family	Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae, that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [1][3]. The orthologous complex in Schizosaccharomyces pombe is not required for meiosis I chromosome segregation, but is proposed to play a similar physiological role in clamping microtubule binding sites [2].  In S .cerevisiae this subunit is called LRS4, and in S. pombe it is known as Mde4.	21.70	21.70	21.70	24.00	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.88	0.70	-5.02	5	29	2009-01-15 18:05:59	2007-10-15 16:21:14	4	2	28	2	18	21	0	226.90	38	72.84	CHANGED	LQLlA-YYcSVL-sE+I...........YhEa..........sp.phpFhuspKTNAscs-.............sphlT-EsLpLQ+Q.......................IsQLssDLQlp+pEsE......................KL+clpKTQKAl......................LESKLpotKupVDphK.....cpossuscupsRssshuts-cppRupthppt+.o.........FHLLSP....IhsscpP.............................sSssupc+p...............uGLRplLcsGcsTIFDp.Sp..cD-.................................sDEDu-pssslpshphutsosR+.lsuL+sos-	................................................LQLLuNYYKuhl-uERI...........Y.EY..............psphphuu.s+hssspus.............sp+ls-ETLhLQRQ.......................lsQLsppLQ.hphpENE.........................................KL.hplQKsQKAL.................................................................hpSKLsopcthIDcLK.cLpspphsscpcspppssssups-pppsspttpss+so..........hH.LL..SP......lssRcps....t.....tsp...........................sSssupc+s...................pGLRplLooG+sTlFDs....Spp.DD-..................................s-sschppDssssp.t....................................................................................................	0	2	8	15
+10255	PF10423	AMNp_N		Bacterial AMP nucleoside phosphorylase N-terminus 	Finn RD, Coggill PC	anon	Gene3D, pdb_1t8s	Domain	This is the N-terminal domain of bacterial AMP nucleoside phosphorylase (AMNp). The N- and C-termini form distinct domains which intertwine with each other to form a stable monomer which associates with five other monomers to yield the active hexamer. The N-terminus consists of a long helix and a four-stranded sheet with a novel topology. The C-terminus binds the nucleoside whereas the N-terminus acts as the enzymatic regulatory domain. AMNp (EC:3.2.2.4) catalyses the hydrolysis of AMP to form adenine and ribose 5-phosphate. thereby regulating intracellular AMP levels [1].	20.90	20.90	20.90	22.20	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.90	0.71	-4.66	67	952	2009-01-15 18:05:59	2007-10-18 11:24:16	4	3	935	27	168	567	55	159.40	47	32.95	CHANGED	ttAVs+LppLY-pusshLpsshpphl.sGs.PsschRA....hYPplRlsssshups......coR..uaG+VstPGsYuTTlTRPcLFcsYLtEQlpLLhpsHsVslpVGsSspsIPhpFslsssstlp.sstssstc......LpchFssPDLushsDcIssGh.apstsstshP	........................s.pAl-+LctLYEpulsALRsAlupYlpsGpl.....P.D.ppsRtt...........FsYPpLsVoaDuss............ps......c..........TR..AaG+hocsGsYoTTlTRPsLFRsYLpEQLsLLhp-YGspIsVpsSppcIPYPYVl-uup.Ls..l.Dcohu.A.s......LschFPTT-LAplsD-hADGlacPsphpP......................................	0	21	76	119
+10257	PF10425	SdrG_C_C		C-terminus of bacterial fibrinogen-binding adhesin	Finn RD, Coggill PC	anon	Gene3D, pdb_1r17	Domain	This is the C-terminal half of a bacterial fibrinogen-binding adhesin SdrG. SdrG is a Gram-positive cell-wall-anchored adhesin that allows attachment of the bacterium to host tissues via specific binding to the beta-chain of human fibrinogen (Fg). SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism which represents a general mode of ligand-binding for structurally related cell wall-anchored proteins in most Gram-positive bacteria. The C-terminal part of SdrG(276-596) is integral to the folding of the immunoglobulin-like whole to create the docking grooves necessary for Fg binding. The domain is associated with families of Cna_B, Pfam:PF05738 [1].	20.50	20.50	20.50	21.20	19.10	18.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.02	0.71	-4.27	35	1380	2009-01-15 18:05:59	2007-10-18 15:44:03	4	52	266	14	22	1140	1	161.70	27	17.80	CHANGED	sshsssthsslsu....pIps...lsppssp..asphlYVNPpppshppss.....lslpG............phspuushsssssplKlYcVsss.ppLscShhssh.s.sphcDVTsph.............phohssNs.phslsFs..slsps..YVl+hsGcasssusp...lshpopLsuhsppt........h..ssshsasN	.....................s.thspppssslpu....plsp...lspsssp..appslYVNP.p..p....s...hssss.............l.lpG................phssuuplssss.splKlYcVsss..s.......p......LscSahsss.........ophcDVTsph..................ploassss..shslsFs....clsps...Yll..hVsu+a-ssuss..slshpsslpshssph...............hssthsas.......................	1	9	10	20
+10258	PF10426	zf-RAG1		Recombination-activating protein 1 zinc-finger domain	Finn RD, Coggill PC	anon	Gene3D, pdb_1rmd	Domain	This is a C2-H2 zinc-finger domain closely resembling the classical TFIIIA-type zinc-finger, CX3FX5LX2-3H, despite having a valine and a tyrosine at the core instead of a phenylalanine and a leucine, hence CX3VX1LX2YX2H.  The structure, nevertheless, contains the characteristic two-stranded beta-sheet and alpha-helix of a classical zinc-finger. The domain binds one zinc and, in complex with the zinc-RING-finger domain, helps to stabilise the whole of the dimerisation region of recombination activating protein 1 (RAG1) [1]. The function of the whole is to bind double-stranded DNA.	20.70	20.70	21.00	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.46	0.72	-3.98	53	4732	2009-01-15 18:05:59	2007-10-18 16:00:50	4	15	3377	1	20	4638	0	29.20	66	5.20	CHANGED	LslRCPVK-CcEEVhLGKYs+HlSSHKEs+	.......LslRCPVK-CcEElhhGKYupHLSSHKEhK.....	0	1	2	4
+10259	PF10427	Ago_hook		Argonaute hook	Bateman A, Wood V	anon	[1]	Motif	This region has been called the argonaute hook [1]. It has been shown to bind to the Piwi domain Pfam:PF02171 of Argnonaute proteins.	23.00	23.00	24.30	24.30	21.50	22.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.80	0.71	-11.98	0.71	-4.13	36	202	2009-01-15 18:05:59	2007-10-19 10:48:31	4	10	53	1	85	153	0	133.70	41	8.72	CHANGED	GpPosPh..ssV..............................cp..GsuhWG+sssS.ssh.tstssssssouWGs....sssuss....suspshpssW..s-csssshus...........suWp-ptssssGh...Ws..spsSp.ssuSh.suuWupt.sst....tthct....uhhu.uphttcuh.hu+	...........................................................h..................................DN..GTSAWG+Ps....so....usu.....WG-...s.ssssssuW....Gs..s.....ssusssh.............KsuuKSMQ..D.GW..GscDhslsusR....suWEEE-..-GGh...WN..osuSQtS.sSS...hssuuWGpt.usK..........+phpp......uhts..Gs..s-uW.MN.....................	0	6	14	35
+10260	PF10428	SOG2		RAM signalling pathway protein	Mistry J, Wood V	anon	Pfam-B_35594 (release 22.0)	Family	SOG2 proteins in Saccharomyces cerevisiae are involved in cell separation and cytokinesis [1].	25.00	25.00	87.00	42.90	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.40	0.70	-5.83	17	158	2009-01-15 18:05:59	2007-10-19 11:53:20	4	23	126	0	122	165	1	355.20	22	46.12	CHANGED	ah+RLSsLP.....Ecctppps.......................h-sllEus+GlLFulhQlpstlp.tlhslspccssppsslc......lhYssssHl-pL.psLcph-stspss.........hpppslhctChohlsuap+lhs.LppslcthhssuDsRYlRshhh.lasShhElpNuhstlss..t..........ppt.........s...h....tp.t.tshhpspphosTts+.sshs.pp.ps................................................sslpps..........................................................phsssss...........................pspscssphs.......s...s.ssPposcoh.shsssssspls..................s..t.spst-cpl....cplappLpsssshshpslsplppphs+shtsuppspp...scsltt....................................hhpsLhcpCpsshclocsLppRLsshp............................................p-sh.shpsphpaW...chspuFlc.................uhlsllsph+plpssh.h..ss-lhshLtslp+uoK-sshllphSsaphl	........................................................................ah+RhS.LP.....Ep.p..hp.pth.................................................................hts..llcsu+tlLauh.plpstlp.thhshhpstp..hpt.s.lp......lhYsspsal-pL.ptlpph-p.stpt...........spslhctC.shlsuatplhs.Lttslphhhs...psDs+alR.l.hhhlasShhElpssht.lss..................................t.............................................h..............ssp...t.t.........t................................................................s.....................................................................................................................................................................s.......................................t..tts.......................sstssp.h...s.t.....t.t............................s..t..p.pph....cpla.tLppshphs.pshs.hppthsphh.t.....uttppt....spthh.....................................................hhppLhppCt.shphochLpp+Ls.hp............................................pps..s.tsp....htha...p.hpsFlp...................shhphhs.th+th...s.h.h...s-hh..htslpcsh+-sshhlt.Ssap.............................................................................................	0	32	67	106
+10261	PF10429	Mtr2		Nuclear pore RNA shuttling protein Mtr2	Finn RD, Coggill PC	anon	Gene3D, pdb_1q42	Domain	Mtr2 is a monomeric, dual-action, RNA-shuttle protein found in yeasts. Transport across the nuclear-cytoplasmic membrane is via the macro-molecular membrane-spanning nuclear pore complex, NPC. The pore is lined by a subset of NPC members called nucleoporins that present FG (Phe-Gly) receptors, characteristically GLFG and FXFG motifs, for shuttling RNAs and proteins. RNA cargo is bound to soluble transport proteins (nuclear export factors) such as Mex67 in yeasts, and TAP in metazoa, which pass along the pore by binding to successive FG receptors. Mtr2 when bound to Mex67 maximises this FG-binding. Mtr2 also acts independently of Mex67 in transporting the large ribosomal RNA subunit through the pore [1].	23.70	23.70	23.70	24.10	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.18	0.71	-4.49	7	52	2012-10-03 02:27:24	2007-10-19 13:07:04	4	1	50	4	32	75	0	161.10	37	88.94	CHANGED	ss.sQ.........s-sFlKKlLApLD......p.ps.sclppalp.F..........ppstIlhNupPhuss......stFLphW.ptsshTpHtlouhDhHlIP..GoGThlsNsssKVRF.DESGRD+hGpsusl.h..............sspshscsRPlWGoaaGlsLpLllD-plhpss.stsIsShNYphVa+P-DSllpI	....................s.s.sphhpsFlK+lLApLD........s.ss.splspalshF..........s.sspIIhNusPhups......stFhphWpsps.tTpHtLouhD.....h...H..sIP......GoG.....Thl..hNsssKVRF.DE..SGRs+hGpsAsl..tss..............ss.spsRPlWGsaFGlslpLllD-plhpss.stlIsuaNYphsY+P-DSllpl.....................................................................................	0	8	17	28
+10262	PF10430	Ig_Tie2_1		Tie-2 Ig-like domain 1	Bateman A	anon	Ciani B	Domain	\N	25.00	25.00	49.50	48.00	23.40	16.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.32	0.72	-3.63	4	53	2012-10-03 02:52:13	2007-10-19 13:35:17	4	11	28	2	19	50	0	95.50	79	9.53	CHANGED	AMDLILINSLPLVSDAET.SLTCIASGW+PHEPI.TIGRDFEALMNQHQD.PLEVTQDsTREWAKKVVWKREKASKINGAYFCEGRVRGpAIRIRTMKM	.AMDLILINSLPLVSDAET.SLTCIASGW+PHEPI.TIGRDFEALMNQHQD.PLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKM	0	1	2	6
+10263	PF10431	ClpB_D2-small		C-terminal, D2-small domain, of ClpB protein 	Finn RD, Coggill PC	anon	Gene3D. pdb_1qvr	Domain	This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA, Pfam:PF00004) it lacks the long coiled-coil insertion, and instead of helix C4 contains a beta-strand (e3) that is part of a three stranded beta-pleated sheet. In Thermophilus the whole protein forms a hexamer with the D1-small and D2-small domains located on the outside of the hexamer, with the long coiled-coil being exposed on the surface. The D2-small domain is essential for oligomerisation, forming a tight interface with the D2-large domain of a neighbouring subunit and thereby providing enough binding energy to stabilise the functional assembly [1]. The domain is associated with two Clp_N, Pfam:PF02861, at the N-terminus as well as AAA, Pfam:PF00004 and AAA_2, Pfam:PF07724.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.63	0.72	-4.08	772	19559	2009-01-15 18:05:59	2007-10-19 14:59:04	4	59	4882	83	4604	13942	5521	81.80	27	12.29	CHANGED	LsccplppIlcl.....lp.clpp.+L..t.c...cp.l.pL..clo-sAhc.hlucp.G...aDstaG.ARPL+RhIQcplcssL.........ActlL....pGp..lt.p.Gspl..pl	.............................................Lsc-slhpIlsh.....tLs..chh.p.p..L...........h.p....cs....lpL.cho-p.A..hc...h...l.Acp..u.......h.....-...........p.....h.....G.ARsL+pll..pc....tlpc.l...............schhl..ttp.h..................................................	0	1527	2924	3867
+10264	PF10432	bact-PGI_C		Bacterial phospho-glucose isomerase C-terminal region	Finn RD, Coggill PC	anon	Gene3D, pdb_1tzb	Domain	This is the C-terminal half of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologues to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate [1]. It is associated with family SIS, Pfam:PF01380.	24.50	24.50	24.90	24.60	23.70	24.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.68	0.71	-4.52	29	276	2009-01-15 18:05:59	2007-10-19 17:18:44	4	2	269	10	113	214	335	153.00	27	45.09	CHANGED	hpphps.A+pLAttlts..tlPllaus.shhtssAhRaKsplsENAKhPAhhshlPEhsHN-lsuhpss...........................htphthlllpsp.-p.ps............thhhshspclh.tpsssshplcsp...usS.hLpclhtLlhlsDasSlaLAhhhGlDPhslshIsthKccls	..............................h...hsN.AKsLAttLss...thPllaus.sshssssucRhtp.hscsutp.Ahsushsch.......+shlsuhtts................................s.ts+h.lllltDc.s.-ttcs.................................tthc......hcpl...h......ts+ssslppl.ph......tu....o.slp+hsuLlhhusaAulYLAltht.................s........................................	0	54	87	103
+10265	PF10433	MMS1_N	MMS1;	Mono-functional DNA-alkylating methyl methanesulfonate N-term	Mistry J, Wood V	anon	Pfam-B_64607 (release 22.0)	Domain	MMS1 is a protein that protects against replication-dependent DNA damage in Saccharomyces cerevisiae [1]. MMS1 belongs to the DDB1 family of cullin 4 adaptors and the two proteins are homologous. MMS1 bridges the interaction of MMS22 and Crt10 with Cul8/Rtt101 [2].  Cul8/Rtt101 is a cullin protein involved in the regulation of DNA replication subsequent to DNA damage.  The N-terminal region of MMS1 and the C-terminal of MMS22 are required for the the MMS1-MMS22 interaction [3]. The human HIV-1 virion-associated protein Vpr assembles with DDB1 through interaction with DCAF1 (chromatin assembly factor) to form an E3 ubiquitin ligase that targets cellular substrates for proteasome-mediated degradation and subsequent G2 arrest [4].	24.50	24.50	24.50	24.70	24.40	24.00	hmmbuild  --amino -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.68	0.70	-6.36	38	910	2009-09-11 06:56:25	2007-10-22 15:39:32	4	19	291	34	656	897	17	467.30	21	40.61	CHANGED	p...hLhluhcS...tclhhLthpp................................psss.......Fh......pshsssssphpphGpplslDPpuRshulsuhpshFtla.Lpp.............ht.phhttst.tsPl...hp........................-GhIhphsFLa...stsssss.hlhhLhhs..ppppschhsYc............Wpsspslppshs+hshs....lssphclP.....shlIPLsp..................ssuallVsspphhlap..........st.......phhshphs............hppsslhssasts............................hppptcclhLsc-sGplhhltlsptst..........php.lGp..sslsssFshLcss........t..lLhsuustGs.uhhlphs.......................................................hspschlpch.NWuPllDhsllc..pppssp....t...............classSGsu.pcGulpplRpGlpup.thphshpph.s.spslWsls.....tssts....ssallhShPhpotlLpl.......................Dhs--l..ht....ulshsspTLtsushs...sshllQVTssulplsshtstphtpphp...........sspplhsAsssssphLlsssspstptlplpht+h.........h.ppt.ph......h..spssslshp...Ph	......................................................................................................................................................................................................................Dhlhlsocp...hphhhlpap.................................ttpth......t...........tshtc.shhp...sG.hhh.lDPp.uRhhhlthh.ct.hhlh.hpp....................p..tt.thtt..l........p.....................................................ph.l.hsh.hhl..................uhtpPhhhh.......l..s..............tpt..t........ph...h..hhc....................................................................................ht...h....sh.p.ch.p.s...........h....phs.............shllsVPt...........................................s..uG.ll.lh.spp.lhYp..........................t...............th......................................................ppshhhsh.....................................................hthsh.hh.L.lt..s.c.tGclahltlphspp..............................lppl+lphh.....s.....p...ss.ls..ss.hs..hLcsG...............hlFluSchGs.s.L.hphs.......................................................................................................................................................................hp.pltl..l...-phs.....sluP..l.hDhpl..s..ch.tp.p.sps...........................................plhsssGts...tc..uoL+ll.RpGltlp.......-hs.s...-LsG..spslWol+.......................................tp.pc..........hcsal..ll..S.....a..s..s....t.Th...lLpl..............................................p.s-.El......pt..GFhs.s.t..Tl.hsupls.....................pstll..........QVpsp.....u.lR...h.l..........................p...s..t.....t...h..hp..p....atss...................ttpsIstsu..ss.p..pp.lllshs.stp.l.hhhph.p.t................................................h........................................................................................................................	0	225	359	545
+10266	PF10434	MAM1		Monopolin complex protein MAM1	Mistry J, Wood V	anon	Pfam-B_58835 (release 22.0)	Family	Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae, that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [1][2]. MAM1 is required in S. cerevisiae for monopolar attachment [3].	25.00	25.00	60.40	60.40	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.08	0.70	-5.20	3	26	2009-01-15 18:05:59	2007-10-24 10:37:39	4	1	25	0	15	26	0	249.80	48	85.97	CHANGED	+cKRsLSsKDTNV.....lp.sNp.ppRpRsL+NKsoh....IsDSSslppPpKNscccpLsKassERpl+RhoNssNlssp-sNs.................pp..oQ+I-NNsAs+E...uG-sLTRssL+ELQppIh-hElssF.pCcHulCsQ.hshcsLcpsRTWFLFELEMoEstsc....NLRpSCYsKYVYoAIDpSW+hsNhLhcAs-supEaFPIEQLLIPc.plD.psppKth-....IEslSI-h-SIhETN+sss.pthV+KKpLPsSVLp+Rsc+clFDEhslDAcEVlNshSoSSS	...................................pKRsluNKDsNh.......l+.sNphpphSRhLspK.......IpsosspcpP+...KNhpccsLsSa+p.-+Sl+.KpNssNlssc-cK-...........................TQcLp...NNlsscE......uscs..LT+sNLKcLQccIF-pEhs.sI.sCcHsLCSs....ENR+..c..IKaSRLWFLFEL-MSt.Nhsc....NLRhSCYsKaVYsAIDcuW..phENILh...cEp-K+Y.........EaFPIuQLLIPN..sIDassc....pK+ccN...I.EDLTlEI-SIIETNHp..........cKRaLPpSlLhKRccchAFDDh.cLDA+KlLNDhSAoSp........	0	1	6	12
+10267	PF10435	BetaGal_dom2		Beta-galactosidase, domain 2	Finn RD, Coggill PC	anon	Gene3D, pdb_1tg7	Domain	This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain is made up of 16 antiparallel beta-strands and an alpha-helix at its C terminus. The fold of this domain appears to be unique.  In addition, the last seven strands of the domain form a subdomain with an immunoglobulin-like (I-type Ig) fold in which the first strand is divided between the two beta-sheets. In penicillin spp this strand is interrupted by a 12-residue insertion which forms an additional edge-strand to the second beta-sheet of the sub-domain. The remainder of the second domain forms a series of beta-hairpins at its N terminus, four strands of which are contiguous with part of the Ig-like sub-domain, forming in total a seven-stranded antiparallel beta-sheet. This domain is associated with family Glyco_hydro_35, Pfam:PF01301, which is N-terminal to it, but itself has no metazoan members.	21.70	21.70	21.90	22.00	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.03	0.71	-4.93	38	264	2009-01-15 18:05:59	2007-10-31 12:16:33	4	20	163	6	155	264	1	166.00	27	16.75	CHANGED	.LstTsttus.sosYo.ssssltso.Lhs......ssTtuuFYVlpHschoStssssapLplsTSs.GslTlPphsG.olsLNGR-SKIhVTDaslG.u.psLlYSTAElhTatphss.c.sVLVLYussGEpsEhAl......uspupshslcGpssslshpptsusllls.aspssshpllplss.....lclhLLDRssAYpa	......................................................s.....hs.sssslhsh.lhs......sto.stFalh.pp..tp.ss...ssts..aplpl..s...T.o.t.Gs.l.slPp.s.......u....slpLsGR-S.K.lhlsDasl......G..s......p........pLlYSTA-lhThtphss.c.sVll.LaGs.tG-tsEhsl....phs.s.t..s.p..s.slpG..sphsh.p.tps........s...t..l.hls..asp.sssh..p.hlplsss.....lhlhllD+psAhp.......................................................	0	48	88	127
+10268	PF10436	BCDHK_Adom3		Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase	Finn RD, Coggill PC	anon	Gene3D, pdb_1gkz	Family	Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c Pfam:PF02518 which is towards the C-terminal.	20.90	20.90	21.20	21.60	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.12	0.71	-4.73	57	905	2009-01-15 18:05:59	2007-10-31 13:35:54	4	12	296	36	574	859	9	170.50	32	40.88	CHANGED	sslSL+phlpF...Gp.ps.............sppp....hh.uupFlppELPlRLA++lp-lppLPhslsppPsltpVpphYhpSFcclhp..a...............................................................................................................pshc-....................spc...Fs.chLpplhpcHs..sl.lsolApGlhEh+..cth........................ssp.......plppFLDcahhuRIuh....RhLlsQH........................lsL.................t..t.psst................................ssa.lGhIss	..................................................................................................................slShcphlpF....Gp...s............................................sppp.....h.SspFlp.pELPl.........RLApplc-lptLP..tlsp...pP..........s.lptV.psh.Yh...pSFpclhp..a...............................................................................................................................p....c.s.hcc.......................t.p.c.Fs.chltplhpcHs..sV.lsshApG...llEh+.cth............................ssp.......................plphFLD+ahhu..........RIuh....RhLhsQH........................ltL...........ht..t.t.sst...........................................spa.lG.Is...........................................................................................................................................................	0	171	289	439
+10269	PF10437	Lip_prot_lig_C		Bacterial lipoate protein ligase C-terminus	Finn RD, Coggill, PC	anon	Gene3D, pdb_1vqz	Domain	This is the C-terminal domain of a bacterial lipoate protein ligase.  There is no conservation between this C-terminus and that of vertebrate lipoate protein ligase C-termini, but both are associated with the domain BPL_LipA_LipB Pfam:PF03099, further upstream.  This domain is required for adenylation of lipoic acid by lipoate protein ligases. The domain is not required for transfer of lipoic acid from the adenylate to the lipoyl domain. Upon adenylation, this domain rotates 180 degrees away from the active site cleft. Therefore, the domain does not interact with the lipoyl domain during transfer.	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.81	0.72	-4.31	94	2280	2009-01-15 18:05:59	2007-10-31 14:37:17	4	6	1825	11	300	1274	29	85.30	33	26.19	CHANGED	coPcFshpppcRFsh.Gtl-lplsVcpGhIpch+IaGDFhus.ts.lpclpptL.hGhpYctcslppsLppl..shp.pYhs.slph--lhphl	...................puPpFshppscRFsh.G.t.V-l..phsV.c.c.GpIpcs............+.Ia....GDFFu....t............-...l.p.slcptL....pGs..pY..c..t..-s..lpps.Lcsl..slscY.hs..slphcElhphh.................................	1	115	189	254
+10270	PF10438	Cyc-maltodext_C		Cyclo-malto-dextrinase C-terminal domain	Finn RD, Coggill PC	anon	Gene3D, pdb_1h3g	Domain	This domain is at the very C-terminus of cyclo-malto-dextrinase proteins and consists of 8 beta strands, is largely globular and appears to help stabilise the acitve sites created by upstream domains, Cyc-maltodext_N Pfam:PF09087, and Alpha-amylase Pfam:PF00128.  Cyclo-malto-dextrinases hydrolyse cyclodextrans to maltose and glucose and catalyse trans-glycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules.	22.20	22.20	22.20	22.90	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.30	0.72	-3.92	32	208	2012-10-02 20:10:03	2007-10-31 15:17:05	4	4	182	12	58	208	92	79.20	31	13.36	CHANGED	cLhHa.sP.psGlYVYhR................................h.sscoVhVlhNpsscshsLsLsRFpEhltssssup-llo.spphsLsc....sLslss+ushllpl	.............hh+F.hP..ppGlYVYtR................................phsscoVhVllNsscpp.tslsls+apEllssps.supDllo.G+pls.Ls.c....slsLss+sshlLEh................	0	21	43	54
+10271	PF10439	Bacteriocin_IIc		Bacteriocin class II with double-glycine leader peptide	Coggill P	anon	Manual	Family	This is a family of bacteriocidal bacteriocins secreted by Streptococcal species in order to kill off closely-related competitor Gram-positives. The sequence includes the peptide precursor, this being cleaved off proteolytically at the double-glycine. The family does not carry the YGNGVXC motif characteristic of pediocin-like Bacteriocins, Bacteriocin_II Pfam:PF01721. The producer bacteria are protected from the effects of their own bacteriocins by production of a specific immunity protein which is co-transcribed with the genes encoding the bacteriocins, eg family EntA_Immun Pfam:PF08951. The bacteriocins are structurally more specific than their immunity-protein counterparts. Typically, production of the bacteriocin gene is from within an operon carrying up to 6 genes including a typical two-component regulatory system (R and H), a small peptide pheromone (C), and a dedicated ABC transporter (A and -B) as well as an immunity protein [1]. The ABC transporter is thought to recognise the N termini of both the pheromone and the bacteriocins and to transport these peptides across the cytoplasmic membrane, concurrent with cleavage at the conserved double-glycine motif. Cleaved extracellular C can then bind to the sensor kinase, H, resulting in activation of R and up-regulation of the entire gene cluster via binding to consensus sequences within each promoter [2]. It seems likely that this whole regulon is carried on a transmissible plasmid which is passed between closely related Firmicute species since many clinical isolates from different Firmicutes can produce at least two bacteriocins. and the same bacteriocins can be produced by different species.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.56	0.72	-3.85	35	1162	2012-10-02 23:56:30	2007-11-06 13:42:44	4	3	367	0	62	351	0	66.30	33	90.98	CHANGED	M.........pphcsLspcpLusl.G.....G.........phspshsuhsuusssGshsGushus...........sGuhsGA......hhGussGuluGt	.........pphM.....hpQFphMDsEMLusVEG..G........sths.s..shsu.ssu......uA.s....s.G.hth.Ghtsssh..............hsuhhGu......hhGuhhsuh...h.......................................	0	6	29	42
+10272	PF10440	WIYLD		Ubiquitin-binding WIYLD domain	Bateman A, Thorstensen T	anon	Thorstensen T	Domain	This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues [1]. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, Swiss:Q8W595, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase [2].	21.10	21.10	21.60	21.10	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.08	0.72	-4.04	8	79	2009-01-15 18:05:59	2007-11-08 17:56:48	4	5	15	\N	49	87	0	63.40	36	13.75	CHANGED	M..ss....p....cRhDAAh-+M+phGhccshlpsslKpLLp..lYscN.WhLIE-DNYcsLlDtIFspc-cp	....................tp....pRhcsAhctMpthGhscppl+sllcpLLp..lY..s....pN..W.hIE-.-sY+sLhDslh-pp-p......	0	5	28	41
+10273	PF10441	Urb2		Urb2/Npa2 family	Bateman A, Wood V	anon	Pfam-B_28626 (Release 22.0)	Family	This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis [1].	21.30	21.30	21.30	21.30	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.29	0.70	-4.75	26	228	2009-01-15 18:05:59	2007-11-19 11:21:27	4	4	205	0	167	223	0	220.80	21	16.86	CHANGED	sssphlsthlphlp...phltpc..shhhsQhsl-hllsllsslst............................p.t.pspsslahphspllsslLthHRh+lss+hHllhsshspLLphLh......sptphssssss.........................ApthuRLlsphs-P.....................p.p.ttts..............Lssthsth+c.hs+ahshlLssYlphplphs.....lsssl+ptLpsGlYuIhDlho..........pp-.lphlsuuLDsuu....RshF+sLYs-Yp+huKWp.p	.....................................................................................................................................................................................t.......hhpsl....hllppc..shthsp.hsls.hlshlsslss.................................sth.pspth.sslahtlppllt....sllpp.....Hpphh.tph.hllsshppL.lpslh.....ttptspt.stss.sps..................................................shphuRL...lpphhp.......................................................................hsttpcthsp.ah.al..lhpY......lph.hcss.......................lhspl+ptLpsGlY....sll....Dlhs..........cps.hphlpuuL...ssuu.......Rs....lFKpLYs-Yt+atKap.pt.......	0	46	84	131
+10274	PF10442	FIST_C		FIST C domain	Borziak K	anon	Borziak K	Domain	The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [1].	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.74	0.71	-4.23	188	1182	2009-09-11 08:20:13	2007-11-19 11:45:35	4	33	821	0	440	1024	155	135.40	19	29.02	CHANGED	AhphYpchlu.....t.t.t........pphst..........................hPlul........t.......................h.ssphh...........................................lRslhtls.tssul.shhsslppGtplphh.ts..spshhpshpphhpph..........................................t..tsthsl.hhsChuR...hht.pt.tppc.lpt.lpchhstt..sl..........sGFhoaGEhtsh	.......................................................................................................thhtchlst..t..............pph...........................hslul....h.......................h..spp.h..................................lRshhth.s..s.sul.thh.s...s....l.p...G.pplph....tp..sssh...hcshppshpph.......................................ttttpstssl.hhsChuR..h.hht...t...t...sp-.hpt.lpphh..s....h.sh.........................sGFasaGElh..h................................	0	126	291	379
+10275	PF10443	RNA12		RNA12 protein	Wood V, Bateman A	anon	Pfam-B_18000 (Release 22.0)	Family	This family includes RNA12 from S. cerevisiae.  That protein contains an RRM domain.  This region is C-terminal to that and includes a P-loop motif suggesting this region binds to NTP. The RNA12 proteins is involved in pre-rRNA maturation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.40	0.70	-5.99	18	149	2012-10-05 12:31:09	2007-11-19 12:57:18	4	12	135	0	119	171	38	416.20	37	49.99	CHANGED	Rp-clcpLppWLtEsssTFlVlpGPRGSGK+ELVh-+sLpsccp.............sLhIDCcplhc.ARsDsthIsssAsQlGYhPVFSWhNSlSuhlDLAsQGLTGpKuGhSEopEuQlpshLpsospAL+cIuLppp...................ccsDcss..........................................................slp---YLptHPEt+.................PVlVIDpF......hp+ucp..suhlYcclu-WAAsLVpsNIAHVIFLTsD.VuhsK.LocALPNp...VF+slsLuDsS.csA+paVlspLtt.......................................................................................................p...................ptstpppptsp.t.......................plp-LDssl-sLGGRhhDLpshsRRl+s.G-oPccAlschIpQuus-IhphFLt........t.tssspsWospQAWpLIcpL...Spsssl.Ys-llhssLFKu.......ssEs..uLpsLEpuELIolsp.ssGpsscI+sGKPlYpAAFppLlsDcslpsthchthlsplIshEsscIcKhE-ELphL.ucl	.............................................Rh-tlpplpt.WLhEsssT..FlllpGP....+GSGKcELVhcpsLps.ccp.............hLlIDCc.l.c.A.+uDsshIpshAsplGY.hPVFoWhNS..lSuhlD.LAs....QGhhGtK..uGhSEoh-sQlp.........pILpsospAL+pluLppp..............ppsccss........................................................................................................................................................plp---aL..ptH..PE.t+..........................PVlVIDsF......hp..K.u.cp...sshlYcclu-WAA.sLsps.N.IAHVIFLTsD.luhsKsLucALPsp...VF.+sl.sLuDsS.-su+paVlspLps...........................................................................................................p..................................................................................pphp-LDssIcsLGGRhoDLphhsRRl+s.Gp.oPppAVpcIlpQuus-I...h+halh...........t.ssp.sppWos.pQAWhLI+tL.................up..psslpYs-llhsslFKu.........ssEs..sLpuLEpuELIolpp.ppGpsppI+sGKPlapAAFppLhp.Dphlpsph-hthltpllphEsppIpKhEpELthLup.h.............................................................................................	0	41	73	105
+10276	PF10444	Nbl1_Borealin_N	DUF2455;	Nbl1 / Borealin N terminal	Mistry J, Hartsuiker E, Wood V	anon	Manual	Family	Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation.  In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p.  In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles.  Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localisation, stability, integrity, and function [1].  The N terminus of Borealin is homologous to Nbl1 [1].  This family contains both Nbl1, and the N terminal region of Borealin.	21.20	21.20	21.20	23.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.41	0.72	-4.60	17	162	2009-01-15 18:05:59	2008-02-06 12:35:15	4	4	136	5	116	162	0	58.40	30	18.74	CHANGED	pphpshlpshshE.lpsRhccl+uphp.hhpshcsth-hclh+lPpulRchpht-lhsch	.........phpuhlcshphE.....l........ppRs+pl+uphp.hhpslcsphchcl.RlPpulRchsht-hhtph....	0	37	59	91
+10277	PF10445	DUF2456		Protein of unknown function (DUF2456)	Hartsuiker E, Wood V, Mistry J	anon	Pfam-B_97171 (release 22.0)	Family	This is a family of uncharacterised proteins.	25.00	25.00	32.10	31.20	24.00	20.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.31	0.72	-4.07	6	48	2009-01-15 18:05:59	2008-02-06 12:37:41	4	1	46	0	35	47	0	90.40	34	26.54	CHANGED	tsLcuh.pspFht..sphhhhpalEWhl.pslRGhlLulhhahhlWPlThGILAuIGp+.tpHDYYFNs..h.hPQVhKLIYGsVlGhlosPllAhlhh	..................hp...h..h......t.phhpalphhltphlRuhllulhhFlllWPlohGILuuIGp+...tupDahaps..h.hhPQlhKLlYGsVluhlsTPlhshlhh....	0	11	19	32
+10278	PF10446	DUF2457		Protein of unknown function (DUF2457)	Hartsuiker E, Wood V, Mistry J	anon	Manual	Family	This is a family of uncharacterised proteins.	30.00	30.00	30.60	32.00	27.10	29.80	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.77	0.70	-5.76	10	78	2009-09-13 16:18:35	2008-02-06 12:38:57	4	4	71	0	66	77	0	404.60	41	60.99	CHANGED	RFHEFASS..EDD-Wlpcs.ssaKpKlTlsDsMKKEpAIRKLGEEAE......EEAhEEE....................-tD-DDspDsDp-Dt..tpt-s...........DsDSslt.hsp..DDGNEoDNEAGFA-S.DE.oDstS-YsFWAPsusTsATos...psl-ssRpshsR+sSsoSh-Shscppsp+p....s.....ppspRpPhKss..+hRPuTPcLPDSTDFVCGTLDEDRPLEsAYhSChEtRRhuKplhIPQDIDPSFPTSD...P-DE-D-.pchp..hshpsD............-usRsRttt.ts++pSPtsSP+RhhSPPP..R.........+ttttS..P++L.RSPPPPh+h+Ss..................sttuusssssoh...sscGlsh..upLspRPshT+TKSLPRTPNsF.......p+hsthsPh.pusE+Euoss+-sHsRGsIDIVcGLEKKRQ+RKEKFaRpHC.RKAsKEphpR.RPhPGKGAERM+ELGLtsAcphhua..ulG...............psuphVLSV	................................................RFHEFuSu..c.-DDWlpps..sshppKlT.lsDs.h+KE.sIRKLGcE.AE........EEA.pEE....................----.--pp..-p-..t..pDp...pp.--..--.ptD....-tp.....-t......s-.s-....p.sp..sD..G.coDsEsGFA-S.DEsD.t.s-hthWsPst..sssssps...tshshhR..s...tc...pt.S....soShtShps.ts.p...............pRp...h+......+h.R.ssT..PsLPDSTDFVCGTLDEDRPLEsAYhSChptRRppKph.IPQDIDPSFPTSD...s..EDE.----..tcp...........ptps-.p..h.pt.........................-t.+sRt......tp+po.ptSP+RhpSPPP..R.......................+.hhupS..P++L.cuP.ss.hRh+SP..................sths.hpshss.....tstu.hph..tsLut...RPsh..s+T+SLPRsPs.F..............................+hp.t..s...tptp.pttspsp-.hHsRGsIDIVtGLE+KRQ+RKEKFappaC.p+A.tK-p.h.pc.....+P...hPG+GAERM+ELGL.hAt...............thu...............pss..hVLSl.....................................	0	13	31	52
+10279	PF10447	EXOSC1		Exosome component EXOSC1/CSL4	Mistry J, Wood V	anon	Pfam-B_6887 (release 22.0)	Family	This family of proteins are components of the exosome 3'->5' exoribonuclease complex.  The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions [1].	21.20	21.20	21.20	21.40	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.03	32	355	2012-10-03 20:18:03	2008-02-06 12:46:39	4	8	310	1	250	337	11	79.70	41	34.22	CHANGED	lPchGslVlsRVoRls.+tApspILsV................................................sssshps........................sF+GlIRppDVRuTE+D+VclhcsF.+PGDIVRApVlSL	...............................lPpsGslVhs+Vocl.st+hAplpIlsV...............................................................ss...pslpp.....................................................sFpGlIR.ppDVR..uTE..+D+Vc.....h.....hcsF.RPGDIV+ApVlSL........	0	84	134	203
+10280	PF10448	chaperone_DMP	POC1; 	20S proteasome chaperone	Mistry J, Wood V	anon	Pfam-B_75798 (release 22.0)	Family	This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (DMP1 and DMP2) have been solved, and they closely resemble that of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them [2].	22.10	22.10	31.80	31.20	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.79	0.71	-4.30	18	73	2009-01-15 18:05:59	2008-02-06 12:51:02	4	1	39	6	47	72	4	144.80	21	96.35	CHANGED	Mphtphppphsst.s....................utcsclslp...thchssKhslsltlNuphDsohcs...sh............hsYhhsl..................pphtushpshlhlusus-hth.sl.spplucLls+phpsss.............hlolSS+hht......t.spssshphLhhlLcsl+	............................M..hphppphstt.t...................sstshplhlp...sschssKl.lsltlssphDsohcss.ps..................hshhhuh...........................ppphushpslshlGsssDhph.sl.spQlucLltcphts.s...............hlohS.S+hht.......ptsssschthLhhlLcslK....................	0	5	23	44
+10282	PF10450	POC1	POC4; 	POC1 chaperone	Mistry J, Wood V	anon	Manual	Family	In yeast, POC1 is a chaperone of the 20S proteasome which functions in early 20S proteasome assembly.	20.40	20.40	21.20	20.80	18.40	20.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.82	0.70	-5.64	3	40	2009-01-15 18:05:59	2008-02-06 12:54:17	4	1	38	0	25	39	0	242.90	33	98.06	CHANGED	MLFKQWN-hstP+H.LD.P.Iu+N.pSLplhPVPcVahPp.hDlspYpssVlTTKIMsPLFPppLLphppIu-IpTTLplcpsp.st-SEcHSWNY-ENFPNEV..s.KpDosscplhuFSaPIauFcDTLIhhIEENFIKhSAIFoNhIoRslIsp.LAQhsPDIp.IsI.GTSDKIsslKpLTpscCoLpPPEFITGFIGSlLTQL...PSKELKVFpsIVAPSEGPIGFEKhoLsslcuLVDlCucLLshcPSc...YSsEChRLWRLDuAAIGAQSGLYI	.........................................................................................................................MlhK.Ws-...P+H.lp..........psh..tshsp.l.h.s....ph..p.hp.hll......t...hhssLFP.cp.L...lphpplG..clpsols.lp...ts.p.......sps.sscc.sasaDEpa.spl........-...cpcst.pp.phhshphPI..aths..c..oLlhshp..-NFlphssI...hsN.hlo+pllsp...L.s.ph.....ps.....-..I...l....ll..us....S...........D+.Is..sh........K...s...ho......ps.....s.....oLpPPEFITGhluSlloQL.........sppshp..hpsLVssSEGP...GFEKlslsshssLlclhu...phLshpspp...Ysppsh+.W+httss...psGLYl.............................	0	3	13	23
+10283	PF10451	Stn1		Telomere regulation protein Stn1	Mistry J, Wood V	anon	Pfam-B_51291 (release 21.0)	Domain	The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA.  Structural profiling has predicted an OB-fold [1]. This domain is the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [2].	20.90	20.90	21.50	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.60	0.70	-5.54	7	123	2012-10-03 20:18:03	2008-02-06 12:56:02	4	9	115	3	95	163	1	178.30	20	49.51	CHANGED	atchtpt.....VsaahspLh+hsphastsp..shhlpDl+pphc.Shphsp....YhshhtshlaWhN+PlppI+llGsllGhpa+hlttp-ahhhplDDCos............hLpCpspcsplhShuhslssh.lGhTlpVhGhhs.......hph.ELpVpalc.hshsLppEIcaWchshph+cpLshPWclss.hltt.hptcpcht.tt...............coPpppps......pssaIEpL...cphcscLplhSPasspsp...........s..lhs...hphlsstspl-pt	........................................htt...................................................................tshhFatN+.PlphlplsGhlluh.p..h.....................t..........c....h..hlh.s..lDDuSG.t...................................slps.......h.....st....tp......................................................G.hl.....plhG.hp..................................t..php...hp.h....hh.........s...httEhthWp.h.ph.h.....L....s.......................................................................................................................................................ttttttttt................................................................................	0	15	45	80
+10284	PF10452	TCO89		TORC1 subunit TCO89	Misry J, Wood V	anon	Pfam-B_61649 (release 22.0)	Family	TC089 is a component of the TORC1 complex.  TORC1 is responsible for a wide range of rapamycin-sensitive cellular activities.	20.20	20.20	20.90	20.50	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	613	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.16	0.70	-5.63	6	69	2009-01-15 18:05:59	2008-02-06 13:00:05	4	5	53	0	46	70	0	286.50	20	51.06	CHANGED	RQFST+SRuK...SsASFKG...L+RVhoHDGThsps.sh.spaushKKoKSSDuLh+RRslSGLsMTALst................puPlp..................huusGL+PcRs+popsVLsL+-upt.hDs-STTDEEVEhFo--p.c.........-Apss......-spstst+stPpppp.h.php.hptp.sh..st.cp.psh.tt..sh+s....hs+.lDSssthh........sc.pI-t......................S+ppppsaDussussslppslsstph.pp............s-h..........................................pt.sHsstpcc.pED+hsssspssp.spssApohtpttccuuptspssppppp..lsD-........p..t.scsp......-pYlPDMILSQSTGVER+F-pplShQNSLu.......................c.tst.s.pthcstphpcs+aNhlppplstsl.ssp...............psptsFSouISSLTssLpRssPpSh.sss+hNss.hp+spQp.L.Rtpph....tt................hspssppssSssplNsFuQFLpSsshsu-SRTQpKLWLQREsSIhDLsuQs.Duu-AlFhASNlEsKREFERIS+EYosVRRFtNPLs-uLpRlp.....ptpshppppppcusouhpuuS.s........hFssY.ppsKohcEhhssupp..hclpplLsuIWpSpotpFNKDsNPL	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ps............+ppFE+lspEY.sVRRahNPls-uL.Rlp.....................th.phppptt.p...s.........................................................................................................................................................	0	11	28	45
+10285	PF10453	NUFIP1		Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)	Mistry J, Wood V	anon	Manual	Family	Proteins in this family have been implicated in the assembly of the large subunit of the ribosome [2] and in telomere maintenance [3].  Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA [4] and is phosphorylated upon DNA damage [1].	22.30	22.30	22.80	22.30	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.02	0.72	-4.46	39	274	2009-09-11 12:31:40	2008-02-06 13:04:56	4	9	247	0	202	267	1	56.50	29	11.43	CHANGED	htptphpshphpG.pplpL....p.T.sE-It+WhcER+KpaPTptplp....cKpptcctptcctph	.......................h.......hth.G...pphpL........p.o.sE...-ItpWhEER+KpaPTpsplc........cKc.phpptp.pctt...............................	0	74	112	166
+10286	PF10454	DUF2458		Protein of unknown function (DUF2458)	Hartsuiker H, Wood V, Mistry J	anon	Manual	Family	This a is family of uncharacterised proteins.	33.10	33.10	33.70	33.50	33.00	33.00	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.93	0.71	-4.32	9	64	2009-01-15 18:05:59	2008-02-06 14:04:39	4	3	62	0	52	65	0	144.90	32	61.78	CHANGED	DsppITsassAL+YVh+plspssch.pcIRcLIpcQccapcpahppR-tLlp+.puph-pp+cL.....-slLpslst.hsp..tp.sp.c.c.ptcLpthDtphhht.pph..t.hthhcsLplPhFhhpp..........................ht..clpp.phhhlplL.D.ltp	.............sphIssa.tAL+hlh+plupscshtpcI+cLIppQcc+E+pWapuRpsLltKQps+ttpp+pl.................cplLpslGs..lsp....p.sss......c........cpptELppa.D.pKVapA.ppMscthptcL+sLulPFFshpp.................................hstc-lpthph+hLplLpDhh.................	0	19	29	42
+10287	PF10455	BAR_2		Bin/amphiphysin/Rvs domain for vesicular trafficking	Mistry J, Wood V	anon	Pfam-B_12557 (release 22.0)	Family	This Pfam entry includes proteins that are not matched by Pfam:PF03114.	22.70	22.70	22.80	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.97	0.70	-5.49	10	190	2012-10-03 12:17:00	2008-02-06 15:55:33	4	5	139	0	139	628	1	273.70	37	82.41	CHANGED	oI.olss+Tp+hlpEpLGpVp.............DISpLPt-YlpLEpKsDsLcKlYp+lLhlo.cTaEs-uYDYPP..shsESlsD..aspolutKhpphtNhoSspcsphhhhGpstp-tsptpKt..................p.sss.hP+TLstALS+sAtcuo..hpcL........................................csp-hssLupshtphSss.tcIupA+h-pDphIlKcFNpcLcclLsppFtKsccLRKKVpcoRLpFDhhRpclcp...................................scPEsEE.............................................t.t..LEshEDEFVSATccAVhhMpcllcsSchlsLLKlFtssQLpYacpuscpLcp.LssLst	...................................................................................................................shAt+T.phlpEpLGpsp.......................................................................Dh.opLPt-Yl-LEc+lDuL+tlap+hLtVT.spYpsEuYDYPs..NlpEShsD..hu+olupKlp...LopAo..SssEA.pshL.hu.Pss.sc.................................PKThsa.Alu+Auhsuot.hpph....................................................ppsssp.cs.L.up.uLcpau.s.p+lupARLs.QDs.Ipo+...F.tshp.ssLNs.s...l...thAs.......+sRKsV-suRLphD..ss+sp..hcst...................................................pp.sph.pp...................................................................................................phchclE..pAED.......E.FVspTE.-.AlslMcp.V..l.-..s.....s.....-.s.L..cpL.t...-L...lsAQLpYa+puhchLpph......t..............................................	0	34	77	122
+10288	PF10456	BAR_3_WASP_bdg		WASP-binding domain of Sorting nexin protein	Coggill P	anon	Pfam-B_43522 (release 20.0)	Domain	The C-terminal region of the Sorting nexin group of proteins appears to carry a BAR-like (Bin/amphiphysin/Rvs) domain. This domain is very diverse and the similarities with other BAR domains are few. In the Sorting nexins it is associated with family PX, Pfam:PF00787.13, and in combination with PX appears to be necessary to bind WASP along with p85 to form a multimeric signalling complex [1].	24.90	24.90	24.90	25.70	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.56	0.70	-5.11	8	753	2012-10-03 12:17:00	2008-02-11 16:57:52	4	10	512	8	150	521	1	143.90	60	42.00	CHANGED	DEKsWKpGKRKAEKDEhVGusFF.TIs.Pph.ssLDLp-VEpKlEsFppFTKpMD-uVhpLpssusEah++psGsh+KEYQKlGpAFpsLupuFphDthstSusLNcAlutTGcsYEpIG-hFAEQP+pDLc.lh-sLs.Y+GhLuNFPDIIpVpKGAlsKVKESp+hstpu+lssp-tsshpcRssshSYAl.AEhpHFHspRlhDa+uhMQpYLcQQlpFYQcIupKLccALspYD	............................................................DDKQWKLGKRRAEKDEMVGAHFMLTlQIPs...EHQ.DLQDVE.ERlDsFKuFAKKMDDSVhQLTHV......AS.ELVRKHLGGFRKEFQRLGNuFQSISp..........A..Fh..L.D..P............P..h.t...S....ps....LspAls.............................................................................................................................................................................................................................................................	0	43	55	99
+10289	PF10457	MENTAL		Cholesterol-capturing domain	Coggill P	anon	Pfam-B_16187 (release 22.0)	Domain	Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops [1]. The function of the domain is to capture cholesterol and pass it to the associated START domain Pfam:PF01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localisation of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins [2].	20.50	20.50	20.70	20.80	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.43	0.71	-4.65	10	190	2009-01-15 18:05:59	2008-02-11 17:18:49	4	7	92	0	107	176	0	151.70	49	43.35	CHANGED	ScVRRpFCLFVTFDLLFloLLWIIp.lssscuIppsL-pEVl+Ys...a+sShFDIhLLAVaRFhlLlLuYAlh+L+HWasIAlTTslooAFLIsKVll...shhSQssFsalLsIsSFlLAWlETWFLDFKVLPQEscsEcha.luu..........................psss-RsPLLsPu..........slScGpFYSPs-Shs	..........................................S-VRRTFCLFVTFDLLFloLLWI....Ip...ls..s.ssuIpps.LcpEllp.Ys...atoShFDIh..lLAhFRFtsLl..LuYAl..h...+.L+...H.....WWsI.AlTThlooA...FLls......K...V.ll......ph........h............op....s.....s..FuYlLsIh....SFlLAWlETWFLDF+VLPQEscpcphh.hhs........................................p.ssstRss..ll.ss..............shSp...upFYSP.-o.u.................................................................................	1	26	35	66
+10290	PF10458	Val_tRNA-synt_C		Valyl tRNA synthetase tRNA binding arm	Bateman A	anon	SCOP	Domain	This domain is found at the C-terminus of Valyl tRNA synthetases.	25.10	25.10	25.10	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.03	0.72	-3.89	31	4203	2012-10-01 23:07:44	2008-02-12 16:38:06	4	17	4133	4	940	3276	1648	65.80	36	7.28	CHANGED	Dl-cEpuRLpKELt+lppElc+lptKLuNPuFlsKAPs-VVEpE+s+lt-hppphptl+ppLspLu	............sh-tElsRLpKEls.KlppEls+lptKLuNEsFVu+APptVlpcERcKhtchppphspl.pppltpl..........	0	326	626	804
+10291	PF10459	Peptidase_S46		Peptidase S46	Rawlings N, Mistry J	anon	Manual	Family	Dipeptidyl-peptidase 7 (DPP-7) is the best characterised member of this family.  It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	698	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-12.83	0.70	-6.11	61	519	2012-10-02 13:45:52	2008-02-15 12:22:33	4	2	290	0	157	649	484	661.60	34	96.35	CHANGED	ADEG.MWh.ppl...p..tsphpp.hGlclssppLhslstss.....hsAlVp.sGGCouuFVSscGLVlTNHHCuauuIQppSos-+saLpsGFhApsts-ELss.PuhplphlpplsDVTcplpsulp..shssptphptlpsthppltpc.sppcs......sh+spVtsFasGspYhLhphpcapDVRLVaAPspulGcFGGDsDNWhWPRHTGDFohhRsYsstsspPAtaups.NlPhpPcpaLplospGlc-GDashlhGaPGpTsRahsssplcpphchshPtplchhptthsllcphhppssch+lpY..AuphsuhsNhhKshtGhhculpchshlspKptpEsplttalppssph.tpatsshsplpthhppppphtppphhhppsht....ss.plhshAppLh+hspctp........pRttuhp-cshstlppplpph..psassslDctlhtthLsphtptsstpc.hsslpp.hlstpt........tt.....hpphscphastopLss.cshhthhpt.stsshps..scDPhlphAhul.hsthtthcpppcphsuthppspttahcAlhthh...spshYPDANtTLRloYGpVcG..Y..ss+.DuhhhssaTTlcGlhcK..p.sGstsFslPpphl-hhpsp-a...Gta..........................t.sssPVsFlossDhTGGNSGSPllNu+GELlGLsFDGNaEuluuDahassshsRsltVDhRYlLahl-clssAspLlcELsl	..................................................................................ADEG.MWh.ppl...p.....ttphpp.hGlplsspplas.stss.....hsAVVp.......h...sG.......G.CTuphVSscGLVlTNHHCuauuIQppSosE.+DYLpcGFhApohs-E.LPs.PshplphlpclpDVTcpVtttlp......st.s..tp...p...pt.....thlpshhpt.lspc.htpps...............shcsplhsFasGNcYaLhhhppapDVRLVhAPPpSlGKFGGDTDNWhWPRHTGDFShFRlYss.ts.spPAtYSt-.NVPh+Pc.paLtlShpGlc-GDasMlhGaPGpTsRYhsuttlcpthpht.ssthphpshphslh.ccthppssp..hRIpY..ASchAu.uNYaKNhhGh.culpchsllspKpttEpphttahpppsp.................t....p.atp.s.hsplpphhspppththpthhhppshh.......ss.....phhphA..hp...lhphttthp...................tct.......th.cpthtp.hppthpph..cs.a.s.plD+plht.thLptYtphss.t.pp.hs.sh.hp.hlspch........tss.....hpthl-t.haspSh.lsstp.........s.ht.......pah...........ptss.hpt..ppDPhlp...huhul..hsthhph.p...pphpphssphpttcphahpuhhchp.s....pshYPDANtTlRloYGpVpG..Y......sPp..Du.hhh.......s.aTThcGlhcK......c..sss...-FslPtc..lh-Lhpp.+-a...GpY........................s.t.GphPVsFl.ossDhTGGNSGSPlhNucG.ELlGLs.FDG.NaEulsuD....hs.F-.ssh.pRsIsVDlRYlLall-KhusAspLlcEhs...................................................	0	62	113	141
+10292	PF10460	Peptidase_M30		Peptidase M30	Rawlings N, Mistry J	anon	Manual	Family	This family contains the metallopeptidase hyicolysin.  Hyicolysin has a zinc ion which is liganded by two histidine and one glutamate residue.	20.20	20.20	20.20	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.16	0.70	-5.58	6	71	2012-10-03 04:41:15	2008-02-18 13:56:05	4	8	52	0	39	167	8	301.10	24	54.19	CHANGED	DsosRsATLppQsTA...oDGssVNhWVEsuE.suuKISsshlcsLsspFAs.sGuIYDhLpslGG.hWGPpu.tuohIs.ssQPlDIVIL......NF-+sGQPaGtlGYFWupNsFppuu..tPhSNcSlSLYLDoETLYLGGpsG..hpslloTMAHEuhHMQNFYRRuVhhGupYua-sWLEEMTAMhMEDhtSppIsssYNsIRDsRF.sYhsYtu.GuYNCuLhpa.TsaGssC-SYuVSGSLGGFLNRQh.GLsFYpsLLopsotosShuVLssAI+sApPuuoLu-tltpaussssuLhPssuuPAGFGaPuRpDusFoLPhIDPs..hhsulRoLs....sulPsTLpuaGoaPVsRosssGTYSETV+VPAGs......TLSVVVc	....................................................................hh...................ts...hh.hWltss..................plop...t.hpplhpcFss........tlYs......hhsslhGp.....s..................sps..s...t....ss.hls......h.Illh........s.h....p....s.s...spshG..h.....h.GYFaups.a....s......t...............tshSNpu..hYl...Dstshhh.ss.s.ss............sp.....h....huTluHEapHMlNF..p+s.lh.....p...s..tt.h.h-sWLpEhhuhshEc..hh.......utph..........................h..s.....sRhs.t.a.p................shs...sslhta...ss.......u.....ss..h..s..Yuhuh.hhtaL..h....cQh.....Ghsh..hhphl...s....s..tssptslhsssh.thsss..s.hsphhtpaths........t...st.asa.t...............................................................................................................................................................................................	0	9	18	26
+10293	PF10461	Peptidase_S68		Peptidase S68	Rawlings N, Mistry J	anon	Manual	Family	This family of serine peptidases contains PIDD proteins.  PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'.  The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.	20.10	20.10	20.60	20.60	19.70	17.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.60	0.72	-4.24	2	40	2009-01-15 18:05:59	2008-02-19 12:42:30	4	27	28	0	19	43	0	33.40	66	4.02	CHANGED	WssL.TtLcctu.+R.hatRspVP+FSWFhVV.RP	.......WuDL-TaLEEEuPpR.hWA+CQVPHFSWFLVVSRP.	0	1	1	7
+10294	PF10462	Peptidase_M66		Peptidase M66	Rawlings N, Mistry J	anon	Manual	Family	This family of metallopeptidases contains StcE, a virulence factor found in Shiga toxigenic Escherichia coli organisms.  StcE peptidase cleaves C1 esterase inhibitor [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.07	0.70	-5.55	15	252	2012-10-03 04:41:15	2008-02-19 13:26:58	4	13	181	1	40	186	20	293.50	42	30.59	CHANGED	EssslsYSsstWSshLPt-Wl+PGlslpF.........spsspsuclts...clGsss-Lhlpolshhhh......TpPhs....psphhc..sclscEhFQ+hPsS+Llsssasst+l-h...VhhP.cu.hhsstsPuhsshpuushR-uhu...l.sGl.NhshGIpuusG-upsuhphhushlh..AhsupGpYsss....................aGG.GGG..GhsThDtohsspFsHEhGHsaGLsH..uGpshu.....satpush.sSsWGaDus+pcFluNhhsssss...hpsCpss.......hss...cG+satpDsMpGGusspss.tsRaohassapsspIQsahcNphh	.............................................................pttlsYupphWSs.lPhsWhpPGloLpl........tcpssppGhlps......IphGussELllpsIDlGML........h...P.Rs....Rs..p...hhpp...tphtt-YFQKlPsS+LlhssYsPhHhph..........Vs.hPsGslhT..-.t....ss.uhGGWHsGsMR-ulG..KthVSoGIsNANhGIsoouGhu.p.....p....a.....shhsspIs...AHss.hGhYs..st..........l............VHGGS..G..GG......GI...VT.L.-sT..h.uN.EaSHElGHNYGLG.HassG..uo......sH.....s.sS...sWGWDu.+pRFIsNh..h.ppss....spptss.........pls.PF.Du.apahhDAMs...GGtsppsu.hsRFThapPhsu.t.hhQcahpNth...................................................	0	24	30	34
+10295	PF10463	Peptidase_U49		Peptidase U49	Rawlings N, Mistry J	anon	Manual	Family	This family contains Lit peptidase from Escherichia coli. Lit protease functions in bacterial cell death in response to infection by bacteriophage T4. Following binding of Gol peptide to domains II and III of elongation factor Tu, the Lit peptidase cleaves domain I of the elongation factor. This prevents binding of guanine nucleotides, shuts down translation and leads to cell death.	23.90	23.90	23.90	23.90	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.53	0.71	-4.54	7	29	2012-10-03 04:41:15	2008-02-21 10:51:40	4	2	29	0	11	41	4	181.90	20	57.80	CHANGED	Iphp.tsLchlWhhsahhhshhpp........l.phhcsss.phcL....................E.spshlpcupphhpahtphlpsh..psas.........ttlPpPth..ptu.p.....tss-lFLpAlualhhHEluHlhhpc.hh.......ssp.shpEEh-sDsaATpalLss.pp.s............+RtluIulAhhhlp.Lhlcpphshps..THPsspsRI.sslpt.p.pts-phh.hhs	..........................................................................h....hphhW.hs...h.hhpt........h......t..................................htht.t.h.hh....p.hp..sh....pt...............thsp.t...t.t........hssplhhhAls.allhHEluH.lhhtH.th...................................s.s.shp-EhpADpaAhchllsphtp.s.p..................hppthuIhhulhhh..lh....p.p.phshpp..oHPshppRl.s.lpt.....tp..h...........................................	0	5	8	11
+10296	PF10464	Peptidase_U40		Peptidase U40	Rawlings N, Mistry J	anon	Manual	Family	This family contains P5 murein endopeptidase from bacteriophage phi-6.  P5 murein endopeptidase has lytic activity against several gram-negative bacteria.  It is thought that the enzyme cleaves the cell wall peptide bridge formed by meso-2,6-diaminopimelic acid and D-Ala	20.80	20.80	20.90	113.30	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.37	0.70	-4.92	2	29	2009-01-15 18:05:59	2008-02-21 11:15:17	4	1	1	0	0	30	0	171.00	92	96.88	CHANGED	VQYSLRALGQKVRADGVVGSETRAALDALPENQKKAIVELQALLPKAQSVGNsRVRFTTAEVDSAVARISQKIGVPASYYQFLIPIENFVVAGGFETTVSGSFRGLGQFNRQTWDtLRRLGRNLPAFEEGSAQLNASLYAIGFLYLENKRAYEASFKGRVFTHEIAYLYHNQGAPAAEQYLTSGRLVYPKQSEAAVAAVAAARNQHVKESWA	VQYSLRALGQKVRADGVVGoETRAALDALPENQKKAIVELQALLPKAQSVGsSRVRFTsAElDSAVARISQcIGVPASYYQFLIPIENFVVAGGhETTVSGSFRGLGQFNRQTWDGLRRLGRNLPAFEEGSAQLNASLYAIGFLaLENKRAYEusFKGRVFTHEIAYLY............................................	1	0	0	0
+10297	PF10465	Inhibitor_I24	Peptidase_I24; 	PinA peptidase inhibitor 	Rawlings N, Mistry J	anon	Manual	Family	PinA inhibits the endopeptidase La.  It binds to the La homotetramer but does not interfere with the ATP binding site or the active site of La.	25.00	25.00	74.60	74.30	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.88	0.71	-4.44	2	11	2009-01-15 18:05:59	2008-02-21 15:18:23	4	1	10	0	0	10	0	139.90	77	89.06	CHANGED	ThsKWF+Is+tDptLpshaPELptGTlhKV...ltpsp-Dh.sDpGIIEl.LssGchlsIYD+shohWChWpocSl-..ElEEl...sp.Vsptshu-FpGERISYALAKLAAQENNDGYEGNLMQAAAEYIEaLEpplS	..TVDKWFRINRADpGLCNYWPELSAGTVFKVRELuKECEDDIEPDTGIIE...IELSDGKIINIYDKPITYWCLWNTESVENGEIEEVVE..RTN..QVVQKPKA-FQGERISYALAKLAAQENNDGYEGNLMQAAAEYIEWLETQIS.	0	0	0	0
+10298	PF10466	Inhibitor_I34		Saccharopepsin inhibitor I34	Mistry J	anon	Manual	Family	The saccharopepsin inhibitor is highly specific for the aspartic peptidase saccharopepsin.\	    It is largely unstructured in the absence of saccharopepsin [1], but in the presence, the inhibitor undergoes a conformation change forming an almost perfect alpha-helix from Asn2 to Met32 in the active site cleft of the peptidase.	25.00	25.00	26.10	39.40	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.43	0.72	-3.91	2	7	2009-01-15 18:05:59	2008-02-21 15:24:18	4	1	7	3	2	6	0	68.40	82	97.96	CHANGED	MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE	...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....	0	1	2	2
+10299	PF10467	Inhibitor_I48		Peptidase inhibitor clitocypin	Rawlings N, Mistry J	anon	Manual	Family	Clitocypin binds and inhibits cysteine proteinases.  It has no similarity to any other known cysteine proteinase inhibitors but bears some similarity to a lectin-like family of proteins from mushrooms [1].	20.60	20.60	24.10	24.50	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.89	0.71	-4.28	2	19	2009-01-15 18:05:59	2008-02-21 15:42:18	4	1	3	6	10	23	0	128.00	42	92.90	CHANGED	LEDGIYRLRAVTTHNPDPGVGGEYATVEGARRPVKAEPNTPPFFEQQIWQVTRNADGQYTIKYQGLNTPFEYGFSYDELEPNAPVIAGDPKEYILQLVPSTADVYIIRAPIQRIGVDVE.GsQtNTLsYKFFPVDGSGGDRPAWRFTRE	............GhYpLRA....sPssGlGG.YATspGspc.VpstPpoPPFFERQlWpl..T..+..s..p..-.GpYTI.p.hpshsssFt.auFSh..D.p..h..PpuPVI.su-..h.E.a.h.h..p.hP.ssspshhIpA.h.hlGhsh..sGs.p.t.pp......................................................................	0	0	10	10
+10300	PF10468	Inhibitor_I68		Carboxypeptidase inhibitor I68	Rawlings N, Mistry J	anon	Manual	Family	This is a family of tick carboxypetidase inhibitors.	25.00	25.00	29.50	29.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.31	0.72	-3.80	2	8	2009-01-15 18:05:59	2008-02-21 15:58:10	4	1	5	10	1	12	0	85.50	43	83.72	CHANGED	lVF.hhVLssupsN-CVS+GFGChPpScCP.EhRLSYsGCsTVCCDlS+LTGCcsKGGECpPh-+.C+EL.uEssSCuctQKCCVhL	..sh....LlllspupAN-CVSpGaGClPcScCPcEuRlsYu..GC..uTVCCDlS+lsuCcu+GGECpPhcpsCKE.LpupouoCs+GQKCCVal.	0	1	1	1
+10301	PF10469	AKAP7_NLS		AKAP7 2'5' RNA ligase-like domain	Buljan M, Coggill P	anon	TreeFam_TF105406	Domain	AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes [1]. AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [2]. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains Pfam:PF02834. Presumably this domain carried out some as yet unknown enzymatic function.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.40	0.70	-4.63	50	426	2012-10-03 21:31:48	2008-02-21 19:00:45	4	20	246	0	280	884	46	205.50	22	57.73	CHANGED	sTHFlulPL.spsp.lppphpchppplL....................................................................tpt.sl..pshhhsspplHlTLsshtLhspp.-lptAt.....chLppsp....pp.......................lhph......pslplpl+.Glchhss.................cVLYA..plp..t......spLpplss....plhcp.FtppGlhh.tspch...........................................phchHhTlhpspht...........................tppp...psh..sspplhccatcacFGphpl..splcLsph.hspss.sGaYcstuslpl	........................................................oHFlulsl..s......p....sp....l.p..p....ht....ph..ppplh.........................................................................tt..s.....tl......tsh.h....h.sstpLHlTls..h..h.......p.Lhspp....clppuh..............phLp.php............tp.............................................................l.p.....h.t.....pslplphp.Glphhss..........................t.s...pVLau....tst..tt..........spLp.phsp.....tltcp...F.p..t.G....lhhtcptt....................................................................................................h.p.hHhTlhpshhh............................................................tpc.....tph.....sspplhc..pa.t.s...h....a......G...p...........l...pplplsph....t.....t..............t.Y..........................................................................................	0	94	145	212
+10302	PF10470	AKAP7_RIRII_bdg		PKA-RI-RII subunit binding domain of A-kinase anchor protein	Buljan M, Coggill P	anon	TreeFam_TF105406	Domain	AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP [1]. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction [2]. The N-terminus, of family AKAP7_NLS, carries the nuclear localisation signal.	22.70	22.70	22.70	23.20	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.90	0.72	-4.14	3	57	2009-01-15 18:05:59	2008-02-21 19:01:47	4	2	29	0	22	52	1	59.70	63	33.75	CHANGED	uuEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKpQPGEGsSVKAEuuDpNGsss-NNRK	...G.uEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKp+P.G-G..SSVK.sEtu.Dp.NGsss-NNRK.......................	0	3	4	6
+10303	PF10471	APC_CDC26		Anaphase-promoting complex APC subunit 1	Buljan M, Coggill P	anon	Treefam_TF101057	Family	The anaphase-promoting complex (APC) or cyclosome is a cell cycle-regulated ubiquitin-protein ligase that regulates important events in mitosis such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins thereby targeting them for proteolysis by the 26S proteasome. CDC26 is one of the nine or so subunits identified within APC but its exact function is not known [1]. The APC/C becomes active at the metaphase/anaphase transition and remains active during G1 phase. One mechanism linked to activation of the APC/C is phosphorylation.  The yeast APC/C is composed of at least 13 subunits, but the function of many of the subunits is unknown. Hcn1 is the smallest subunit of the S. pombe APC/C, and is found to be essential for cell viability, APC/C integrity, and proper APC/C regulation. In addition, Hcn1 phosphorylation indicates a specific role for the phosphorylation of this subunit late in the cell cycle [2].	23.90	23.90	24.60	24.80	23.80	23.80	hmmbuild  --amino -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.70	0.72	-3.24	42	164	2009-01-15 18:05:59	2008-02-21 19:08:13	4	4	145	8	112	156	0	79.20	22	53.31	CHANGED	M.LRRpPTsIpLo.-.DltcaEct+pcppppppppppppp.....................tt.sttp.ssptp.lsscptphhpptspthu	....M.LRRpPTplpLph-.Dl.p-aEsh+pcpppppppppphpt.............................t...t.s.sttstspt..t..................t............................................................	0	32	51	84
+10304	PF10472	CReP_N		eIF2-alpha phosphatase phosphorylation constitutive repressor	Buljan M, Coggill P	anon	TreeFam_TF105548	Domain	This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation [1]. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus [2].	25.00	25.00	54.80	54.00	17.70	17.20	hmmbuild  -o /dev/null HMM SEED	411	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.40	0.70	-5.76	2	32	2009-01-15 18:05:59	2008-02-21 19:10:12	4	3	24	\N	15	35	0	362.50	65	55.21	CHANGED	MEsGTttuRKR.GPRhG.hFh.PFh.RRSpAsSScFPsP.u.pNsGN.....SA.PEpRspYWTKLLSQLLA.LPuLhQKlLlWSQLFGGhhPTRWLDFAusYSALRAL+GREcsAAPTsQKSLSSLpLDSS-s.VsSsLDWLEEGlpWQhSssDLcLcLKAptpALDsAA.sFLLEQQLWGVELLPSSLQutLhSpRELsSSsSGPLslQplsNFpVVSYLLNPSYLDhhPpLtlphQsSsGsuphVGFpTLTPESshLpEDtCHPQPLpAEh.ssuWptCPPLSTEGLPEIHHLRMKRLEFL.QANKGQ-LPTPDQDNGYHSLEEEHsLLRMDPpHCpDNPsQhVssAuDhP....EsTEcK.ELlhpEV.....ppSPptus..sElPhEKEstEs+hsssDhS.htt	..............Es...t.sR.....t.t.hFh.P.F.h..hpSpsssSphPsP.ustp.ts....sSs.PpsRsp.W.hKLLSQLLAPLPuLLQKlLlWSQL.FGGMhPTRWLDFAGsYusLRAL+GREcsAAPTAQ.K.SLSSLpLDs.S.-sussSPLDWLEEGlHWQCSssD......LcL-LKAKGsALDPAApAFLLEQ.QLWGVELLPuSLQu+LaSsRELGSSPSGPLNlQRlssFsVVSYLLNPSYLDChPRLElSYQNSsGsGELVsFQTLTs.ESuCLpED.tCH.PQPLsAElosASWQGCP...PLSTEGLPEIHHLRMKRLEFLQQASKGQ-LPTPDQDNGYHSLEEEHsLL.RMDsKH......C......pD..sPTQhVPsAG.slP.GssQEsTEEKIELLTpEVPLALEcpuPo.EuCPSsE....lPhEKEPGEsplSVVD.S.lc.s...........................	0	1	1	3
+10305	PF10473	CENP-F_leu_zip	Cenp-F_leu_zip;	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1	Buljan M, Coggill P	anon	TF101133	Domain	Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [1,2]. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to be binding DNA directly in this instance [2].	33.00	33.00	33.00	33.20	32.90	32.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.95	0.71	-4.32	30	150	2012-10-08 13:49:02	2008-02-21 19:16:05	4	14	53	0	66	118	1	136.90	33	13.97	CHANGED	DEKKpL+lhEcLKESc+cuDsL+D+VEsLERELEhSpcNpEpslL-AEsuKAElET....LKscl-phsppLpsLEhDLsslR.......SEKEsLs+pLQccQp+VSELEthsoShcsLLcEKEp-...+lQhcE-oKsAlEhLQsQL+ELsE	...........ccKpLcltpcL+cscccpssLcc.+lEsLEp-Lphupcspppshh-uEsu+tElps....Lcscl-phsppLpsLch-Lsslp.......pEK..csLsppLpccpp+lpELEphp...ss...hp..phlp...ptEpE...chphtcp.psshp.LppphpcLpE.................	0	3	7	24
+10306	PF10474	DUF2451		Protein of unknown function C-terminus (DUF2451)	Buljan M, Coggill P	anon	TreeFam_TF106152	Family	This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2450.	26.40	26.40	27.10	26.50	26.10	26.30	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.48	0.70	-4.61	12	199	2009-01-15 18:05:59	2008-02-21 19:22:53	4	8	130	0	132	188	1	211.50	37	25.45	CHANGED	LYGLppRhlAsEShhhlAcphchhcshlpphLPtpptsh.........lppFasp............slus.ls-lRchlapsssuphlslp.............shlsthsslKW-lpEs.sspHssYVDsl.p-hppFsh+Lppht.ppssls.c..h.tsLW-pslplhtchL....V-GauplKKCostGRALMpLDhpphhstLEplost+..s.chpaV-sYIKAaY....LsEp-hcpWhppp................pEYohKplsuLVptssuu......s++tRpcLLshl-s	...........................hYGLsERlVAsES.lhhlupthch.h.pshLpslhsts.pp.sh.............LppFasp................hl.ss.s.s-L+c.lahhsusph.l.chp.............................................................phl.hhusl.K.W.-l+El..hspHs.YVDhLlp..-.hpp.F.spRLtphs..ppstlsh....lpplLW-pslclsscsl....VEGau.p.V...K.KCSsEGRALM..QL..DhQphh.pL.........E...+l...s.s....h+.......shP..c......tpaV-..sYIKAYY....Ls.E.s..-.hcpWl+pH................pEYStpQlssLlshshss......p+ptRpplLthl-.........................................................................	0	56	76	109
+10307	PF10475	DUF2450		Protein of unknown function N-terminal domain (DUF2450)  	Buljan M, Coggill P	anon	TreeFam_TF106152	Family	This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2451.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.85	0.70	-5.51	12	433	2012-10-03 17:31:52	2008-02-21 19:23:24	4	20	221	0	301	888	8	203.70	22	22.10	CHANGED	l-ulEtsYFpp......cFDssha.Lc+lssst..hshpp......l-cptsplppQtchluc+l.phlhppppshspthpplp-lcccLptusshCtsuR+pLstuppphTphsLtlhupp+K+psLhphL.pLsslKphpsh-hclcphlp-usYstAlplL.EspphhpsappasClp-lspplpshhthhtppLDshL.plstsF-scpYsplhpAYtLLs.+spthh-KlpphFlpslcopopsVL+shhp.t.....pscchp+hsYppLCtplsp-pah.CLhchhpsLaclhhSYaplhpa	..................................................................................................................................................................p.-+Lpp.h-hVp...hplhppI.ppppuah.puhsp.lp.pLpsp...lptu...st...tsp.......p.hR.c..p..Lpthcp..t.h...sp..s..uLp....ll.p.....pp+Rpsl.....h.t.lhp.....tLptl.p....pl......ppspsplpth...........l.....p................p.s....-.ass...A...l...p...ll.......p.sp..p..h..h....p..p..............h.t..t..h...p...s....h...p...p.....l...t...p...pl...pph....t.htp..h...........................................................................................................................................................................................................................................	2	109	163	246
+10308	PF10476	DUF2448		Protein of unknown function C-terminus (DUF2448) 	Buljan M, Coggill P	anon	TreeFam_TF106107	Family	The family DUF2349 is the N-terminal part of this family. This protein is found in eukaryotes but its function is not known.	19.60	19.60	19.60	20.30	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.39	0.71	-4.80	3	69	2009-09-10 19:42:20	2008-02-21 19:24:03	4	3	37	0	30	52	0	195.40	60	34.97	CHANGED	aRRoREADKAFlK..STuuVuoPspVILLRILAFLACAFLlAsTLYGhs-..pS.sspQTLSGGVlPPK...suNsScASDpTssuupuWQDLhGLLPE+ATEsl+lsWQaGpsHQhAVVSVGLLTCLTAlLlAGPIRLRRIDAhASVLWhLlLCLYLAEsYLpTsuPSWLDTlKFuTTSLCCLVGFAAAVATRKSTGPRRARsRRs.sst	.........+R.READQsasQ......s.SSuVKuPsQVILLRALAFLACAFLLssALYGsSc...........shss.Gus.lPPu..........GssuS.s.s.s..s.s.TssuA-GWpQLLuLLPEHssEKLpEAWAFGQSHQhuVVAlGLLTCLLAMLLAGRIRLRRIDAFuosLWALLLGLHLAEpYLpssoPSWLDTLKFSTTSLCCLVGFTAAVATRKuTGPRRaRPRRa....ss.........................	1	1	4	11
+10309	PF10477	EIF4E-T		Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E	Buljan M, Coggill P	anon	TreeFam_TF101531	Family	EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localisation signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation [2].	19.70	19.70	21.20	20.00	18.50	19.60	hmmbuild  -o /dev/null HMM SEED	578	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-13.04	0.70	-5.72	5	194	2009-01-15 18:05:59	2008-02-21 19:26:45	4	5	79	0	92	179	1	427.30	31	63.88	CHANGED	YSK-ELL-IKELP+S+cRPuCLo-KYD........................SDGVWDPEKWHuSLYPuSupSsPsEuhKK-pDs-RsoLKRRIsDPRERVK-DDLDVVLSPQR...............................................RSFGGGCpVsussuSRRssSPLE.K-s-uhRLh....................GuRRIGSGRIhs.......................................uRsFERDaRGsch-RcsEcsRDRE+-aKDKRFRR-aGDsK.........RVFu-RRRND....SYsE....EEPEWFSAGPTSQSETIELpGFDDKILEED............p+u+KRo++Ro.....pSlKEshVECNGGlu.c.c.slslspEsuADQEVPcsssLPEs.................sPG-FDFNEFFN......h.s.h...-psht.ss.usSRFS+WFp.............................................hEsttps.h..hc..t.tp.phhP..psL-psh.P+LsSh.ppsh..s.ss.h.....ht.ssspppshFpcLLs...............h.sN..sp..ph...............................hss.P..s.la.ptt..h....pph.s..s.hs..pt.htt..sshs.h..h.hhhph.shptps.slst.......t.phhs..p....p...pp.ppphhpp..sphshs.l.ph.............sS.hs.uFTPTSVlRKMhccKcKc+	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.st.h............................................................................................................................................................................................................................................................p.......................................c..pPEWhs..Ppo..-hI-LhGF-..-.....................................................................................................s..........................................t.........................................................................p.p.....t......hp..........................................S.h...ht....................................................................................t..................t....p.............................sh.t..p.....h.......p..lp..........p......s...ts......................t..............p......h..pc.hlt...........tt.............................................................................................................................................t......................................................h........................................t.....p..............................................t....................t.t..t..pt......................................................................................................................................................................	0	26	33	65
+10311	PF10479	FSA_C		Fragile site-associated protein C-terminus	Buljan M, Coggill P	anon	TreeFam_TF105915	Domain	This is the conserved C-terminal half of the protein KIAA1109 which is the fragile site-associated protein FSA [1]. Genome-wide-association studies showed this protein to linked to the susceptibility to coeliac disease [2]. The protein may also be associated with polycystic kidney disease [3].	18.80	18.80	23.30	21.70	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	615	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.01	0.70	-6.45	4	151	2009-01-15 18:05:59	2008-02-21 19:31:11	4	4	85	0	95	148	0	477.70	45	20.51	CHANGED	sosSssusspQhTsWETLVlFAINascLNVQMNMuNVMGNssWhTpshpSpGRLSlGSssc+sh.hulsLGuSpLDAKGGlVGGTI-lNplchhhH..IpE-ssppPsHKhtIphhulEh+lDYMGoSVLMs+hSuhshplpDEWKssppsshssthspp...u.IhlHGDLoWDpLQlMISKSTTsDllKhhhKLpEFFoQQFKoSKRlhSsLp..PpLtspo.tAslc+Rppcp.......L..............DAtHHRHWp+sLc.ssGhhls.pLhs.LsccGshlGGohEL+GpsISLACFHG.NF+uKSWALFpL+-PsIsFsTEAph.....pSscp...lhlhQTLshpLGpsTtsQp.....ppshAsVsRlo...RN.haP.phcolpEWF...........cYuhA..NpEl-slcphPh.EsEpptso...solpRhRuuGSups..tph.thNHNpEsIFALPuLQL+FKopHlQGsssP-ht-s....KPcV.CSFlT-FpDHIhVTsDA-A.hhFLHDLloSYLpEKEKslus........Pp....hshpP..........................Gp.ssL..hpsSHospuss..........................................usSuTtsoVsupppp................DWRcFpCpTWHLEPTVRL...lSWsG+pI-PhGlDYILpKLGFpHARTTIPKWLQRGhMDPLDKV.AlhhlpLLhh	......................h..........phssWETLVlFAlNhppLsVpMNMuNVMGNssWhTpshpopGRLolsSstc+ph.huluLutSpL-u+GGlVGGsl-lst..lchh..............hH...........Ip...E..csspp........P....tHpl.tlphtuh-hRlDYMGoulLMuhhSshshplpDEW+h...s....h.sshs.s...pc...........................u.IhlcGcLpWD.hQlhIo+STTsDllKhhhKLpEFFoQQFcoS+Rs.hSoht....shl........sts...ssh..cppptpp....................................-s..tHHRHW.tlL..................thh......sshhl.s...h.h.LPp..p..u..h.........hGGohpL+GpphoLACFHG.NF+.S.KSWALFpLc-PsIsFhTEAppl.........p...psppp..........shlsQTLshpLGps.....s.............hpp...............pp..sMAsls+lo....Rp...P.thtolpEWF............................................................................pYshA..spElsh.lcp.h.sh.pt..-pthss.....s.hpthRusu...S...........................hNHppE..sIFALPphQLchKo.HhQ.tspp.Pshp.-s.........KP..pV.-CShlTEFpDH.IhVThDA-h.hhFLHDLlouYlKEK..E+s.hhs............p....hs.ps.......................................................................tp.ss.h...p.tspsphtp...................................................................................t.s.s.psh..............................................................DWRcFhC..pTWHLEPTl.R.L...lSWsG+pI-PhGVDYILpKLGFpHARTTIPKWlQRGhMDPLDKllullhhpLh..s......................................................................................................	0	39	46	75
+10312	PF10480	ICAP-1_inte_bdg		Beta-1 integrin binding protein	Buljan M, Coggill P	anon	TreeFam_TF105393	Family	ICAP-1 is a serine/threonine-rich protein that binds to the cytoplasmic domains of beta-1 integrins in a highly specific manner, binding to a NPXY sequence motif on the beta-1 integrin. The cytoplasmic domains of integrins are essential for cell adhesion, and the fact that phosphorylation of ICAP-1 by interaction with the cell-matrix implies an important role of ICAP-1 during integrin-dependent cell adhesion [1]. Overexpression of ICAP-1 strongly reduces the integrin-mediated cell spreading on extracellular matrix and inhibits both Cdc42 and Rac1. In addition, ICAP-1 induces release of Cdc42 from cellular membranes and prevents the dissociation of GDP from this GTPase [2]. An additional function of ICAP-1 is to promote differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state [3],	25.00	25.00	26.20	28.40	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.30	0.71	-4.54	2	77	2012-10-04 00:02:25	2008-02-21 19:31:49	4	2	49	0	42	66	0	168.10	64	91.50	CHANGED	MFRKsKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSG..NssSDssAEFRlKYVGAIEKLphs.uKsLptPLDLINYIDsAQQDGKLPFVPs-EEhIhGVSKYGlKVuo.DQhDVLHRHsLYLIlRMlCYDDGLGAGKsLLALKTTDspppEhSlWVYQCsShEpAQAICKVLSouFDssLsSEKP	....................................................MFR.KGKKRHSS.S.SSQS.SEISTKSK..SVDSSLGGLSRSST.VA.SLDT...D..........STKSS.G..QS.NsNSDTCAEFRlKYVGAIEKLchs-uKsLEGPLDLINYIDVAQ...QDGKLPF.V.P.E..E.EhI.hGVSKYGIKVoo...sD.QaD..........VLHRHuLYLIlRMVCY..DDGLGAGKsLLALKTT..DuppEE...........hSLWVYQCsSh-QAQuICKlLusuFDslLss-..............	0	11	13	24
+10313	PF10481	CENP-F_N	Cenp-F_N;	Cenp-F N-terminal domain	Buljan M, Coggill P	anon	TreeFam_TF101133	Domain	Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore [1]. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein [2].	25.00	25.00	28.50	25.00	24.70	23.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.24	0.70	-5.05	10	64	2012-10-08 13:47:38	2008-02-22 09:02:08	4	10	40	0	34	53	0	257.70	59	11.94	CHANGED	MSWAVEEWKEGLPo+ALQKIQELEuQLDKLKKERQQRQFQL-SLEAALQKQKQKVEsEKoEuusLKRENQSLhEoCDsLEKuRQKlSHDLQVKESQVNaLEGQLNSsKKQIEKLEQELKRaKsELE....RSQpuht....su-spLsssoTPQKoFusPl.oPuphapDu+hE-LpEKYNKEVEERKRLEsElKsLQ....s.KKhsQs.lsQuTloHRDIARHQASSSVFPWQ.QEpTPS+tSusuhETPl+RssousahsWEpE-TPsKss.p.tptpt.soShtussssopLh-QLKsQNQ.EL+S+VsELEhRLQuQEK-	.......MSWAlEEWKEGLPoRALQKIQELEuQLDKLKKE+QQRQFQL-SLEAALQKQKQKVEsEKsEsssLKRENQpLhEhC-sLEKs+QKlSH-LQVKESQVNh.EGQLsSsKK.......QIE+LEQELKRhKSELE....RSQQutt....uuDspLs.ssTPQK..FsoPL.TPs.....opaE-LcEKYNKEVEERKRLEtElKsLp.....s.K+hsps.lsQuThsHRDIARHQASSSVFsWQ.QEpTPS+.Stss.cTPh+Rshuuuah.hE.EsoPs+ss.p.tptst..uuh.ssspsspLhcQLKsQNQ.......EL+u+lsELEhcLQupEK-..................................	0	7	10	18
+10314	PF10482	CtIP_N		Tumour-suppressor protein CtIP N-terminal domain	Buljan M, Coggill P	anon	TreeFam_TF106469	Domain	CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control [2]. This N-terminal domain carries a coiled-coil region and is essential for homodimerisation of the protein [3]. The C-terminal domain is family Pfam:PF08573.	27.00	27.00	28.00	32.70	25.90	24.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.66	0.71	-4.32	4	111	2009-01-15 18:05:59	2008-02-22 09:04:36	4	3	51	0	55	100	0	115.10	67	16.20	CHANGED	FtEhLs+LKEhHDKEl.GLQsKlscLppERChDAQRlEEhFoKNppLREQQKlLpEsI+VLEcRLRAGLCDRCsVTpEhh+KKQpEhEss+.psLphIotLpNEhpoLpEEN+pLpEELc	..Fp-hhsKLKEhH-KEVpGLQsKlscLppERh..hD..AQRL.EEhFoKNQQLREQQKsL+EoIKVLE.............c.RLRAGLCDRCsVTcEphRKKQQEFENh+pQNL+LITELh....NE+NsLQEENK+LpEpLp........................	0	2	6	17
+10315	PF10483	Elong_Iki1	Hap2_elong;	Elongator subunit Iki1	Coggill P, Eberhardt R	anon	Pfam-B_26773 (release 22.0)	Family	This family is a component of the RNA polymerase II elongator complex [1,2]. This complex is involved in elongation of RNA polymerase II transcription and in modification of wobble nucleosides in tRNA [3,4].	27.50	27.50	27.50	27.80	27.20	27.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.69	0.70	-5.04	22	253	2009-01-15 18:05:59	2008-02-22 09:11:26	4	4	198	3	176	260	0	240.80	20	82.24	CHANGED	LLp+lLSL+-.sSPLhLlLDSLtQsup.LlpEal++u.....t.pp.cllalSFEThpc..PphsspFlssp.............stshppllppltst.........stspssp..cpLlllDSlN.lhsp.......plspFlushh.sPt.......sollusaHp-.............s......ahPuslslLpalAoTllclpsh.p..hccpshcpplsc..hsht..hsss.................shslplppRRKSGRult.pahlssss+.h..hhp.........c-....................sphsp...--sEt....hTFNLshocKQ+tAREpV.LPah-AQpt.u........usGGtIlYE	.....................................................................................................phh.t......sshhL.h.Dslt..uh.llpthhp.p........t.t...lhhlu.hp.s..pp.........t.hs..htsp.........................................th.s..th.tt.hth..............................tt.sp..............thhlhlDS....ls...lhtp.............ph.phluphh..pst......................................................ss.llshhHp-l..................................a.P.t.s...hshLphlAsshlplps.......h.........t..................................................................th.hph.hR.....R+s.G......R..s..h....p..t...hhs..t...sp.......h...................tp............................................................................tt.st....psp.t........hTFNLtL..oc+p+ps+-plsLPah.upp.....................ttsutIhY-..............................................	0	54	92	137
+10316	PF10484	MRP-S23		Mitochondrial ribosomal protein S23	Buljan M, Coggill P	anon	TreeFam_TF106116	Family	MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs [1]. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system [2]. MRP-S23 is significantly up-regulated in uterine cancer cells [3].	37.50	37.50	37.80	37.70	32.20	30.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.61	0.71	-4.24	9	115	2012-10-03 14:45:55	2008-02-22 09:19:38	4	2	85	0	64	100	0	123.60	46	73.18	CHANGED	Au..SRLEKlGTIFTRVpGLL+uGAhKh--+PlWYDVYtAFPP+tEPcYsRP....sPps..sVRpIaYtEDslRAKFac.ps+uptshsLhs.spposoQpFlphYppLcspG..sh-EEh.......h.cTupsLht-tlh.p	......AtSRLEplGolF..oR.scsLlRuGslK...-KPLWaDVYpAFPPhcEPhacRP.......tsct.......sl....p...cIaYpEDtlRAK.....Fap.....hssu.c.shsLh.......ssshp.SssQ+FVc+Yp-Lpp.G..th---p.......a.-TucsLLu-thh..p.............................................	0	20	25	45
+10318	PF10486	PI3K_1B_p101	DUF2447; 	Phosphoinositide 3-kinase gamma adapter protein p101 subunit	Buljan M, Coggill P	anon	TreeFam_TF102035	Family	Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits [1].	18.20	18.20	18.80	19.60	17.40	17.20	hmmbuild  -o /dev/null HMM SEED	857	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.68	0.70	-6.97	4	166	2009-01-15 18:05:59	2008-02-22 09:24:22	4	4	47	0	94	139	0	485.90	28	92.84	CHANGED	ToCTEDRIQHALERCLHGLStss.hSopWsAGLCLNhWSLpELVsRDsGpalILlEplLt+sREsQcpspY-LlhPLALhFYasVLpAPaIP.sS-LL.KAhuhaHpFLTWPsPYCsVhpEhLoFIssEhKAPGIoYQRLVRsEQGLPs+sapSSTsTVLLlNPsEVpuEFLS...lApcLSsspps.csshspLlpHhaQAohGs+CcssuLHppLpA+slccLp-IaosssEA.EhAuu.s.-su.uREtLps+Lp-l.....uttAGh.sGshssupPs+lpPIPhPsu+CYTYSW-QDsFDlLsplLhpEspL..lps.lhu-DEEs--EE...--c.EssGpsP-RDSlhSs...h.p.ss..................S.tss..phssLu++.hp.FVSuLSsshDSGYsEDS-EuSpEhsthsp.p.ERupp+.tp....+IhpLFKoKuplshR+....Lpss.s..........stsLPLRRAGShssP..p..p.PuRu+Ro+SLPQ.thGpph.s...hst.hs..RRPFLSsD-D.....sKluThRVVVFGSDRISGKVARAYSNLRh+EospPhLTRaFKLQFaYlPVKRS...ssu.hhsP....toPSPss...ht.s.u-......EtSTNDISHYlGhLDPWYcRNVhGLMpLs.ssLC.QShKtEAE...shEsSpTphPILADMlLYYCRFATRPlLLQlYpsElTF..loG-KpTElFIpsLEL..........GHSAspRAI+ASGPGuKRLGIDGDp-slPhTLQIsYSKuslSGRSRWsslEKVCTSVsLpKACpp.EELsSphE............CLNLslTEVVKRQNSKoKKSFNQlsTSpIKlDKlQIIuppus.FslCLDQDEpKILQsVlRCEVSPCY+PEcsDhsphs+sP..sLsuQstsEhpSL....LCLPIsTFSGAlP	...................................................................................................................................................................................................h.h.........hh....thh.ph..hhh.h...hhhP.shtsh..phh....lp.E....ss..Gh...a.pc..hlhtEQtl........p.............p.p......hhlhhs....h.........h..............p.tt.....t............t.h..h..ll.p..hpsshG...th.h.tltt.Lp..........hh..h...h.p.........t.............h..h......................................................................................................................................................................................................................................................................................................................................................................................................................................................p......pttt.hh..hhphphahhPh.........................................................t..p......lu.hlu.hD.WYptsh.............t...................t.................hh.Dhh.aYhR.u...hhh.ha.hp......t......pphhh.tl..th...............................................................................................................................................................................................................................................................................................................................................................	0	9	19	49
+10319	PF10487	Nup188		Nucleoporin subcomplex protein binding to Pom34	Buljan M, Coggill P	anon	TreeFam_TF101106	Family	This is one of the many peptides that make up the nucleoporin complex (NPC), and is found across eukaryotes [1]. The Nup188 subcomplex (Nic96p-Nup188p-Nup192p-Pom152p) is one of at least six that make up the NPC, and as such is symmetrically localised on both faces of the NPC at the nuclear end, being integrally bound to the C-terminus of Pom34p [2].	25.00	25.00	29.80	25.20	24.50	20.70	hmmbuild  -o /dev/null HMM SEED	931	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.60	0.70	-6.63	4	230	2009-09-11 16:46:00	2008-02-22 09:32:58	4	8	183	0	149	233	0	642.30	25	42.33	CHANGED	cphstlspFLppsKppLLE.Lshhp.psTppu-pscs+chlAp.lLthslpspcF.upsEc.LsphLph.l.Ec.phl.chhhsl..hss.c..pthh.cLcstsahpp-Rl....stllpp...llcllophlssps.hsupshpshppL-pEla.s.cpplpsLl........................-hhhspsllaClchhp.LLpLhllNtsVssphsppWF..h.sphlt.s+LhpsTshu........t+ahshp-hs...phhlu+lpuhholloI.hLsLsouh-pup.shso..shhtDspsFchVsssLhs..-sspp.........shVLYuWShILht+.hh.pp.s...............Fs.sp.tphIphhuppA-slsVhppLpcLschLp.D....slaTslhssahhhSlshIslTupTopshtslIsssPcslIEsFlsNssapsc........lshl+uKhPLl...LhPhIpL..A.IsschAtaphccltSa..lsKhshhs..Ychhs.s.hscpso......-Llchpu.lLVhPP.hEpss.ph.hslPpuTKupIls.......................usps.ps.......LlhF.YpYNGWoLlGRlLQNL.+la....sshDs.Q+.EhhIsIIsLlsNVlsscsuV-cShhlLp.hSs.hsps.......sIlpVIaclhEp..uLpp+shcllspCsshhTsLssphsahVWsYLs+SsLL................-phGKsGLuNlIhGSIEhssG-YsFTISllKLspsLIcssLo.....s.thsp+oKpsIlspllhHLlclaEoahhW+YNpph.Q+hEIuhhLhphFpsILt.VasID.tssspsKlppl......hocAAspllshFLlss-s.shsstolhshl.s.spspohh.hGsu..spLYspslppAaslssLlIsIRsss+.LpPSsLE+hLF...sposcLlslY.ph......Po...l+lpIlcLLssLssssWssth.P.LhSaLGps.utshLcullsDLsoslpDaplthoLY.FhssllEoKQ-GLulLFLTGcssss	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....h..........................................h............lPtsThGplh..........................ssps..........llha.ap.asshshhsp.l.p..hh..p...sh................................sp.s..p....p.p.lh.ll....s..Lh.tpl............l..........p.t.....p.................s........h.......t.....p.......s.....h...........................................slhshlh.....lhpp........sl..............s...................s........lpl..lsuClphlssL..h..sh.....Ps+VWs.L.t.+os.hL.................................................ps..s.t.u.G.h..hshl.h.....s....h.E.spGcYshhluhlcLh...psLlc.s...tls......................................pp....t..........psl..........l............s....h....h.h....hh.h.-hh.shtpW+ass.t..+..plsthlhphhptl.L.hsa.....t.h...s....tt.s.....ps..plptl......................hspuu.ph.llshhh..hss.ss....thshs.............s.p..s.t...hpt......hh..phlp.shphsp.ll.p..l.p..............p..h..ss..............L.EptLh............ttu..s.t.L..ltlhshh.....................ss......h..th.p...ll....c.h.........L.ts.....l...s......s.......................................SlhuhLGs.p.u.t.t.hhpth.lsplpp....h.ps.plp...h.lhcFloshl.p..sp..hLh.hhLshp.....................................................................................................................	0	41	72	112
+10320	PF10488	PP1c_bdg		Phosphatase-1 catalytic subunit binding region	Buljan M, Coggill P	anon	TreeFam_TF105548	Domain	This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels [1].	23.90	23.90	26.10	25.30	20.60	23.20	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.00	0.70	-5.23	5	184	2009-01-15 18:05:59	2008-02-22 09:35:22	4	6	97	0	70	171	0	131.80	36	35.04	CHANGED	shPISshsuCSsc..sah.thAsc-lpoSSsspSI........Sas-EuE-uuuoSDSSphEu-hE.-sEG-+LW-shscSsDPYNPLsFTAslQTssT.sPKs.o.ptpshSspps..sSsuEuPlsSss-sSoSsDDSW-uSuDEEEst...cLWsSFCpNDDPYNPLNF+APhQoSucs.cus+hDSsosStssVuI........put+SoR+Sp+A.LlsKlpccCs+pLSsEoLSls.hptclh.s.spGs++cosKlKKV+FSPsVpVH+MssWSaAhctuRKGPWEEaARDRCRFQKRItETEcAIGYCLohpHREKMasRh	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h+...+V+F...s.....t....s.p...l+hlssWsh..uuctuR+G.sWEphAtDRsRFp+RIscsEthlusCLssptRtRhhsR......................	0	13	17	39
+10321	PF10489	RFPL3_antisense		Ret finger protein-like 3 antisense	Buljan M, Coggill P	anon	TreeFamB_TF341410	Family	This short transcript is purported to be the antisense protein of exon 2 of RFPL3 gene, however this was not confirmed. Since the RFPL3 (ret-finger protein-like 3) gene is expressed in testis the suggestion is that this may have a role in the antisense regulation of the RFPL genes. RFPL transcripts encode proteins with tripartite structure of RING finger, coiled-coil, and B30-2 domains, which are characteristic of the RING-B30 family. Each of these domains is thought to mediate protein-protein interactions by promoting homo- or heterodimerisation [1].	27.00	27.00	29.70	29.50	26.30	26.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.63	0.71	-4.34	6	31	2009-12-01 17:09:26	2008-02-22 10:15:53	4	2	5	0	4	22	0	71.80	47	51.62	CHANGED	MGNLCGCIQGDSKKPSKKRVKRKPYSTTKVTSGSTFNENTRRYAVHTNQCRRPHGSRVKKKRYPQEDDFHHTVFSNLERLDKLQPTLEASEESLVHKDRGDGERPVNVRVVQVAPLRRESRsI-	...................t...D..htsS+chspcc..Sso..pVos.soh.t.hRRYul.TpQt.R..s...+Kth.s.E........................EEs.shKctGsGER.VpsRVhps............................	0	4	4	4
+10322	PF10490	CENP-F_C_Rb_bdg	Rb-bdg_C_Cenp-F;	Rb-binding domain of kinetochore protein Cenp-F/LEK1	Buljan M, Coggill P	anon	TF101133	Domain	Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [1,2]. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains [3].	19.20	19.20	23.40	34.30	18.60	16.10	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.44	0.72	-4.64	4	55	2012-10-08 13:53:08	2008-02-22 10:18:33	4	10	32	0	26	45	0	46.60	67	1.96	CHANGED	sp.tpspEso-aEP-GLPEVVp+GFADIPoGcsSPYILRRTThuppsSP	.....hpstEcpEso-FEPEGLPEVVKKGFADIPTGKTSPYILRRTThuTRTSP....	1	1	4	10
+10323	PF10491	Nrf1_DNA-bind		NLS-binding and DNA-binding and dimerisation domains of Nrf1	Buljan M, Coggill P	anon	TreeFam_TF105308	Family	In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].	20.30	20.30	20.30	26.00	18.40	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.48	0.70	-5.18	4	147	2009-01-15 18:05:59	2008-02-22 10:19:02	4	6	78	0	85	152	0	178.40	61	35.18	CHANGED	GPVGVAAAAAIATGKKRKRPHSFETNPSIRKRQQTRLLRKLRATIDEYsTRVGQQAlVLssoPGKPNslFKVFGAsPLENVlRNhKuhlLpDL-sALAp+AP.Ppspss.sl.ELPPLlIDGIPTsV-KMTQAQLRAFIPhMLKYSTGRGKPGWGKESsRPsWWPpDLPWANVRSDsRoE-pKpKVSWTpALRpIVhNCYKaHGREDLLPtFtEp	..................................GPVGhAAAAAlAouKKRKRPHsFEoNPSI.RKRQQsRLLRKLRsTlD.EaoTRVGQQAlVL........shoPu....K..PNssaKVFGAtPLEsVl+ph+shlh--L-sAL..AppA...P...P......ss........ELPPLsIDGIPsSV-KMTQ..AQLRAFIP.MLKY.STGRGK.PGWG+ESs+P..WWPc-.l.PWA.N..V.R..Ds...RoE-.pK..Q.+.............V.S..WTpALRpIVhNCYK.HGREDLL.sFt-p.............	0	25	31	59
+10324	PF10492	Nrf1_activ_bdg		Nrf1 activator activation site binding domain	Buljan M, Coggill P	anon	TreeFam_TF105308	Domain	In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss:Q8C4C0, there is an activation domain at 303-469, the most conserved part of which is this domain 446-469.  Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3]. The family Nrf1_DNA-bind is associated with this domain towards the N-terminal, as is the N terminal of the activation domain.	19.10	19.10	19.30	19.30	18.70	18.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.36	0.72	-3.54	7	86	2009-09-16 13:14:49	2008-02-22 10:19:52	4	5	61	0	50	83	0	60.50	45	11.56	CHANGED	othlslPV....S..MYQ....ThlA.shtQh.........lsPh.QV..........psG............................husthHthhhpussu.ts...Qhl..pVloLcs	................GlVpIPV....S..MYQ....TVVT.SlsQs..........suPV.QVAhus...lssc.u-ph.Th.............................................................s.....................................	1	12	16	30
+10325	PF10493	Rod_C		Rough deal protein C-terminal region	Buljan M,, Coggill P	anon	TreeFam_TF101176	Domain	Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localising first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10 [1], and indeed the two proteins function together, localisation of each depending upon the other [2]. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase[2]. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint [3].	20.30	20.30	22.00	21.40	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	551	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.84	0.70	-6.21	6	118	2009-01-15 18:05:59	2008-02-22 10:27:05	4	3	83	0	78	103	0	461.60	32	29.23	CHANGED	cGhhhP.lA+hRLPF+Lll...ppshhsILssELo.Esa.oLLLlsphhps.........shDhhhhSAsKpsh.pchK.phhcpsssppaplhs+s.sthlQoIhphlcslsssphAhhIhahlTppsP...........................-GsDplpAhhhChchAccacpslssps-A+-K....hcKlph+Y.lptTpplLhsatLNDpchL+lltpPscLIsALYcHosl.pp.......shsDIpslVpEIAclpsLslppIpshLLpKWLshhhsu.......................lhc-pshs-sss-lEsss......sltRshYlLpuashs..puVhFLlu..souLhsssshosup+pLtlhssaphh.sDsssoahcphhpcphhsLKClhaLpuLthhNI..TlppFps..osK.ullKtLWpsHuppPpulcllAplCLtYclYsPQlWNGlLp+hltFNh..................................lsaLptlL-slSuhcpLaplsuFupAWctlIptPFhoAspshS.sQpusLt+oLVhL.KCPlstsLsLlsIAchhlplshPuhA.usLLhhsps-cpcQpIKphluossspslhQQItEL.ssG.luslsptlsstl.s	.......................................................................................p....hs.huphRLPF+.lh.......tpshhp....Il....ssELs..-sh.phh.lsphhph.................shDphhhssspp....h.pphp......p...t..ptpp...sl.spp.....tthh....ps.l.phl.sl.ssp...husshhh.lspphP.............................Gs.+hpuhphChhlucc....a.h...psh......ss...p...s....cs+c..c..h...p..........hpKlch....pa....tpptTEtl..Lhsa.....t.Lss....tchLc....llspPscLIhsLYcH.sl.pp..........spshs.DIpssscEIAclp...plslpplh.hLLpKWLs..............................................................................................................hps.t.p.t.spph.php.p...cp............sLp.RlhYLLp......shshc......pthhal..h.........s...h.h..h..shp..p..ho.hsp+tRAlpsLhh..ls.sp-..........slpoh.........h.........cp..shpclp.hLKClh....aLsphEhLslsh.oh-hFps..ssKpuhlKu.LW+s..a.uc.psh....ulcLlspLCL-YclaD.pl.WNulLp..+lltFsM..................................l.shLpplLp.slo.sh.pLhpl.s..hspuWppllphPhhsAs.s.s.pQ.tth..cshlhl.tCPl..sLshhthApphhphphsthA.usLh.hspspcpppplpthlt.p....lhpQl.-h.phG.lshh.p.h......................................................................................	1	24	30	55
+10326	PF10494	Stk19		Serine-threonine protein kinase 19	Buljan M, Coggill P	anon	TreeFam_TF105332	Family	This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP [1].	21.00	21.00	21.00	21.60	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.77	0.70	-4.98	22	201	2009-01-15 18:05:59	2008-02-22 10:40:10	4	3	164	0	134	203	0	230.00	26	72.35	CHANGED	h+sshhcplsh.hsshs.pphspllphRps.lPs.llshsplau.....lh..pssThV-+pl.pLl+pGtlR+hhlss..............tthhhhhcshctllppsshlps...................hp..................................c+Flphlpppssshhhs....pphFsttp............hstLlpsGh.Ls..........................sthssss...............................a.lSlPssGsal+LlsuGRpaLlshLp+...s+a+Ehh.spLpc+W.Ghs.........................+hp.hYGhshcWhLp-slGAGllElFsT.slG.uhRh	....................................h.............tshp.hh.h..hthhps.lPP..llhhuplau............ll..ps.ThV-RpltpLhcpGtlRhhtlst...........................th.Dhcsllh.ppshhpp..........................hhp................................................................h..........pcFhphlh.s..s.t..s.shs......pphhotpp.........................lstLlpAGh.Lsh...........................................p..csts......................................................................ahlulPshG.al+hhspGRptllshlp+...s+a+Eh.hs.LhpR...............................+h.thhtlshpahlc-hlGuull-shpT.ssGhhlRh......................	1	37	71	105
+10327	PF10495	PACT_coil_coil		Pericentrin-AKAP-450 domain of centrosomal targeting protein	Buljan M, Coggill P	anon	TF105408	Domain	This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly [1].	25.00	25.00	25.50	27.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.47	0.72	-4.05	18	211	2009-01-15 18:05:59	2008-02-22 11:00:32	4	5	142	0	139	223	0	80.90	41	3.77	CHANGED	+hhRpEoFR+uLsaQK+Yl.LhlssaptCppssLphlscM............GspPs.......tphpcs+p+a+oslpsllAlhR........................M+hlsccWp	...........+YLRsESFRKALlY.QK+YLLL..hl..suaQpCEpssLphlAch.....................................Gst.Ps.......htpp.cshs+FRoAlpsslAlsR........................h+als+cWp....................................	0	33	51	93
+10328	PF10496	Syntaxin-18_N		SNARE-complex protein Syntaxin-18 N-terminus 	Buljan M, Coggill P	anon	TreeFam_TF105868	Domain	This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates [1]. More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes [2].	21.20	21.20	21.20	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.86	0.72	-4.15	33	245	2009-01-15 18:05:59	2008-02-22 11:01:51	4	3	213	0	167	252	0	81.90	26	24.35	CHANGED	sDlTslFpp.Vtpsp......pp.ss.s............tptthtph.phpDpFlKEAhclhppIspLpsaLpplRpsYlshs......tsphopspcDph	....................DlT.hF+t.Vtthc.....................ptttt.s..................tp...htps....tspssFhccAhclhspIspLcpaLhphRpsYls...h.p.h.s.htp...hoctpcs................................	0	43	84	132
+10329	PF10497	zf-4CXXC_R1		Zinc-finger domain of monoamine-oxidase A repressor R1	Buljan M, Coggill P	anon	TreeFam_TF101076	Domain	R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.76	0.72	-3.90	13	365	2009-09-11 09:20:48	2008-02-22 11:03:32	4	20	145	0	233	361	3	98.80	40	16.64	CHANGED	IYDshpGpoCHQCRQKTh............Dh+ssC.....psppC...hp..Gp.........................FCGcCLhsRYGEcscEshtssc.WhCPhCRG........ICNCS...aCR+K+GhsPTGlLh+pA+tpGasSVtcaLh	...............................................................................hYs...GpoCHQCRQ.KTh............-t+.s...C................c...s..spC....tsp.....sp..................................FCssCLhsR.YG.E.c........lccs...h.............h..s......s........s...........WhCP.CRG...........ICNCS................hCR++....c....Gh...ss...TGhhhhhsp..GatsVtthL..........................	0	60	121	173
+10330	PF10498	IFT57		Intra-flagellar transport protein 57  	Buljan M, Coggill P	anon	TreeFam_TF106156	Family	Eukaryotic cilia and flagella are specialised organelles found at the periphery of cells of diverse organisms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated [1]. This protein is known as Huntington-interacting protein-1 in humans.	40.00	40.00	45.40	49.90	39.80	39.10	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.03	0.70	-5.71	18	178	2009-01-15 18:05:59	2008-02-22 11:11:11	4	3	124	0	127	178	4	298.40	38	81.42	CHANGED	ME-Ll-KLKLLsYEccahcptp..hKPLoRaYFu....hssNPuEQFahFosLssWLhs..psG.psh-pPpEaD..DPNuTssNILs-L+shG..hss-FsPsKL+sGsGEtVshlLssLu-puLpppsF...sa++Ppasp.......-c..s-pcsh..-DDs-hhhpcl---...-sp-p--.............hhp.th.....s.tttspsptllcSplDstEWplElERVhPpL..Klpl+sDs.+DWRsHl-phpphpcslppthspspthLc+.....lps-ls.psLE+lpoREchlNsQlpphlp-.a+ptppphsphpcphpphstulpphpttLsclspcL-plKpch-E+ssshoDsuPlhplKpuls+L+pEIppMsl+IGVlp+olh	.....................................................-plh-KL+lLpY-..pphh.t..p........h+s.s+aYFs.....ssN.....suEQFahFstLssWLhp....ptG.p.hptPp.E......aD...DPN.sshspIlttL+phs..hss-FsPsKL+pGhG-tshhlLstLuppALphh.ta...pap+.s.hs........--......p.tsh...-D-sE.h.hhpcl--ph...ttpcs--............p..hhp..t.........th.ttptptppl..hpopsDst-WplElERVhPpL........KVp...l+.s...D......s..+DWRhHl-QMcphpssIpsth..pcscs.Lc+.....Lps-lscsLEKItoREKalNs..QLcphlpc.Y+shptpLupspcpappsssslscpop.Lsc....ls-cLEplKpch-E+GsshoDu.uPllpIKpuls+L+pEhhpMsl+IGllppsl..............................	0	62	73	104
+10332	PF10500	SR-25		Nuclear RNA-splicing-associated protein	Buljan M, Coggill P	anon	TreeFam_TF105478	Family	SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing [1]. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway [2].	55.00	55.00	55.50	55.40	44.10	50.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.98	0.70	-4.88	6	90	2009-01-15 18:05:59	2008-02-22 16:23:21	4	2	66	0	53	97	1	186.70	48	80.28	CHANGED	spS+S+SpShsc...ptpcp+c+.......pp.psppR.pptt......................pcshKKt++Rt+.........ppSSSSSSSoSsSsSppp.ppcp+K+Rtt+KpK..t+KcKKct++.cKcupcct........E.ttlscAhsts.Lchhpppst.pt.sP.............shTDEQKu+lpsh+PhTKEEY-ARQSVIR+VVDPETGRTRLIKGDGElLEEIVSKERH+EINK.............QATRGDGttFQtRs.Ghh	..............................................t.................................................................................................pt...tptpp.p..t............up.sSSo.SS..S......SoS...S...S.....sS...s......p...p..spppt+KK+t..KcK........c.K............p.c+K.cKK+....c..KKhKK+...sKc+t..........ptpt.......sc....s.h..Pssslct.hpcps..tpcp.s..sP................lhTDEQKSRlpAM+PMTKEEW-ARQSlIR+VVDPETGRTR..LI.KGDGEVLEE...I.VoKERH+EINK............................QAT+GDGhhFQh+s.sh.h.........	0	15	20	36
+10333	PF10501	Ribosomal_L50	Ribosomal_S39; 	Ribosomal subunit 39S	Buljan M, Coggill P	anon	TreeFam_TF105895	Domain	The 39S ribosomal protein appears to be a subunit of one of the larger mitochondrial 66S or 70S units [1]. Under conditions of ethanol-stress in rats the larger subunit is largely dissociated into its smaller components [2]. In E. coli, in the absence of the enzyme pseudouridine synthase (RluD) synthase, there is an accumulation of 50S and 30S subunits and the appearance of abnormal particles (62S and 39S), with concomitant loss of 70S ribosomes [2].	25.10	25.10	25.10	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.29	0.71	-4.10	30	196	2012-10-02 01:16:24	2008-02-22 16:43:46	4	3	179	0	144	199	2	108.30	23	36.59	CHANGED	pphssssplpph..l.ppstppsht...........................s.s.sahphsLsD.phKFtFlKphppphG+hlPDstlpplpTlpclhpah.......psss...cscp.sctl..ptcthshP.NVplhpct	..................................................................p..h.sspphpph..l............phhpphht.......................................s.sa.phsL.p.D.phKFphlppltpphG..HhlPsspLpph....pol............pclhsah........spss...pspphh-tl....pthsLP.Nl+lh.c.........................	0	28	59	106
+10334	PF10502	Peptidase_S26		Signal peptidase, peptidase S26 	Mistry J. Rawlings N	anon	Manual	Domain	This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesised secreted proteins.  Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.88	0.71	-4.65	32	3046	2012-10-02 16:34:55	2008-02-25 12:55:21	4	13	2357	14	823	4403	991	93.00	32	34.94	CHANGED	lhhNsosShPlGLYplpshsp........hpsGclVhsssPpssAhhhA.pRGYLspGl......PLlK+VhAlsGpcVshsssh.lsl-G..lshupshtpDphGRsLPsap.tstslssGElFLhu.ssssSaDuRY..FGPl..ssSul..lGhApPlaT	.......................................................................................................s.......................................................................................................................................................................................................................................................................................................................................................................................................................................................p.......h...........h......VPtGp.Y.FhM........G.D.....N.....R..s..s....St.DS........R......Y.........a......G.....h.....V..P.cpsllG+A.h.lh.h...............................................	0	221	509	690
+10335	PF10503	Esterase_phd		Esterase PHB depolymerase	Mistry J, Fushinobu S	anon	Manual	Family	This family of proteins include acetyl xylan esterases (AXE), feruloyl esterases (FAE), and poly(3-hydroxybutyrate) (PHB) depolymerases.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.53	0.70	-5.10	2	1139	2012-10-03 11:45:05	2008-02-25 13:32:45	4	32	653	0	468	2296	946	182.10	23	48.03	CHANGED	LAYtLYlPP.....Gt.R...PhVVMLHGCpQps--FAtGTRMNhLAcchGhsVLYPEQo.RApsptCWpWac.pppptGRGEssslAuLsculsstHthDsuRVYVAGLSAGuuhAslluhpaPDhFAAVulHSG.shGpAssshoAhssMRpG.t.sPussssAhssA.....hPsllhpGDuDpsVts+NA-pLssthhphsGhusupGA.tuu.RVpptpoG	............................................................................................h....hal.P..s..................s...h....t......s...h..s..Ll.V.h.LH..G.........C.....t...t........s....u.....p....s......h.....t...p.........s......o.....t......h....s.........p.........l...A....-...p....t...s......a.l......V......l....Y...P........p....t......s............t.....t........s.......t............s..........p...........t....C.......a......s.........h........h.s..............s........s.....p.......p.....p......s.......t.......s......-.....s.............s..............h.........l......t...s.......h.....l....p.....t...l...h...p......p...a....s.........l...D.......s.s..R..V..a..ls..Gh...SuGu..hM.s..s.h..hu..s.........p..........a.......P.-......l........F....A....A.......s....u..........h....h......u...........G.....h.......s......h.....s......s.....h..................s....................................................................................................................................................................................................................................................................................................................................................................tsttsts..................................................................................................................................................	0	165	303	401
+10336	PF10504	DUF2452		Protein of unknown function (DUF2452)	Buljan M, Coggill P	anon	TreeFam_TF105992	Family	This protein is found in eukaryotes but its function is unknown.	20.70	20.70	21.50	21.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.96	0.71	-4.96	10	150	2009-01-15 18:05:59	2008-02-26 12:47:45	4	1	134	0	83	166	179	138.60	36	80.19	CHANGED	spVsLVEsNPsP.sGhplVSPYpouRhu-PhDLVsLApplQcADphI+sNACsKLTVIAEQIRaLQEQARKVLEEu+RDtDLHHAACNFsK+PGpIYaLYcR-SGQpYFSMLSPcEWGs.SCPHpFlGuY+LEHDhSWTPhE-lEcpDsclchs-+Llspss	....................................................t....................ss..sthh..s...DlltLApplppADp.hl+sssss..KLp.lIs-QlphLQpQA+clLc...-uccstcLHpusCNFhKtPGplYaLYpRp....s....GppYFShlSPcEWGs..ss.s.p..c.alGuY+LptDhSW..T..Ph-clpppptphthhpphh...s..............................	0	30	42	62
+10337	PF10505	NARG2_C		NMDA receptor-regulated gene protein 2 C-terminus	Buljan M, Coggill P, Berhardt R	anon	TreeFam_TF106272	Domain	The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2.  NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse , six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi [1]. This C-terminal domain belongs to the PD-(D/E)XK nuclease superfamily [2].	20.70	20.70	20.90	21.60	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.32	0.70	-5.16	5	96	2012-10-11 20:44:46	2008-02-26 12:56:43	4	4	76	0	65	111	1	201.00	35	25.27	CHANGED	--cS-hlsPsNuNoshpLWoLQpts-.......DaplhlRhSlsslc...cocupcslts+F..l.l.lKLEYQs-aGsEtMSKSELl+tWscphL+suohuasuRISA+TaclhLcEKLTLtsLEcpL+caYsoShsNLLoHLhphLKlLsulPsGDYLLpHus..KDKFLLslhosDspsTPsSasLH.l.pTcoussDpPuloussWlPIDPoLlsphHcEpsLLPCoFPs	.........................................................ppsphhts.pcuNhsYpLaoLp......................-lhLLVRsS......lptlc...csppccpl.pp.ph...slhlhPKlEYQssa.Gs.EsLTcSELs+hWspohL+ssspha.su+IsuhTu+lhhlEclo.ppL...ccp...lsshp...s..shhslLpcl..........LK....pL....s..uLptGs.YLLpHss...cDs.lllhKss-......p....s.o..csu....asLa....pscss.ssh.s.s..h...p.ssWlPlDPslhhshHhcptRlPCoFPs.............................................	0	20	25	43
+10338	PF10506	MCC-bdg_PDZ		PDZ domain of MCC-2 bdg protein for Usher syndrome	Buljan M, Coggill P	anon	TreeFam_TF105384	Domain	The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.	21.50	21.50	23.80	22.30	21.30	19.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.99	0.72	-4.14	7	229	2009-01-15 18:05:59	2008-02-26 13:21:28	4	6	60	0	113	229	0	64.60	36	16.56	CHANGED	ccLpuplEcLcshNchLstsLpthKtpsEphsh.lGctEupAsAL..+LALpapp+shEsashhhAlht	......c+LpuplEcLcStschLsts.E-p+ppstchshhlt+t-ushsAh.....+Lth..papp+scEh.shLhAlhE......	0	20	28	55
+10339	PF10507	DUF2453		Protein of unknown function (DUF2453)	Buljan M, Coggill P	anon	TreeFam_TF105823	Family	Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.	25.00	25.00	25.00	25.60	23.70	23.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.34	0.72	-4.26	16	194	2009-01-15 18:05:59	2008-02-26 13:33:18	4	15	115	0	142	191	6	101.10	44	34.68	CHANGED	hsuulPFlGFGFLDNulMIlAG-hIDpslGhhLGlSTMAAAALGNllSslhGlthtshlEphsp+ls.hphPsLT.tQhc.ptsphusplGsslGlhlGClLGMhPLLFhss	.................hsulPFlGFGFlDNhIMIlAG-hI-holGhhhulSTMA..AAALGNllSDlsGlshush.lEths.p+l.......G..hph...........P....sLostQhc.....h.........hps+husphGpslGlslGClLGMhPLlFht.s..........................	0	65	83	122
+10340	PF10508	Proteasom_PSMB	Proteasom_PSMB5; 	Proteasome non-ATPase 26S subunit	Buljan M, Coggill P	anon	TreeFam_TF106231	Family	The 26S proteasome, a eukaryotic ATP-dependent, dumb-bell shaped, protease complex with a molecular mass of approx 20kDa consists of a central 20S proteasome,functioning as a catalytic machine, and two large V-shaped terminal modules, having possible regulatory roles,composed of multiple subunits of 25- 110 kDa attached to the central portion in opposite orientations. It is responsible for degradation of abnormal intracellular proteins, including oxidatively damaged proteins, and may play a role as a component of a cellular anti-oxidative system. Expression of catalytic core subunits including PSMB5 and peptidase activities of the proteasome were elevated following incubation with 3-methylcholanthrene. The 20S proteasome comprises a cylindrical stack of four rings, two outer rings formed by seven alpha-subunits (alpha1-alpha7) and two inner rings of seven beta-subunits (beta1-beta7). Two outer rings of alpha subunits maintain structure, while the central beta rings contain the proteolytic active core subunits beta1 (PSMB6), beta2 (PSMB7), and beta5 (PSMB5). Expression of PSMB5 can be altered by chemical reactants, such as 3-methylcholanthrene [1].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.55	0.70	-6.23	9	249	2012-10-11 20:01:02	2008-02-27 11:21:59	4	12	149	0	143	379	6	365.10	21	83.06	CHANGED	htshhpchlpplpst...phh-pLsthpsslstps.hptlspth.........lassLs..os....p.-ph.lthplLcplltshsscsh...hsphpshLpcGLspssssl+thshhp....ltRhlpppsushphlsspslh.hlhhsltspchssuptAhphLsplsppphthctl.......pspLpslhpp.s-hlRhRlY-lslcluuhSssshshptp...lhcplLpElps.-DVLlphssl-llscLAp.spaGhpaLtppulh-plsshlptscpDP...hushhlsGhh.....+FastlAsh.ss.plhpsaPphhpplh...phhsstD.shhssAhDolGhlutsl-GKphL....+sssshcphltthusttp.hshch+hphLpulsslh..tppptpppl........shscsWYpphuppshp....lhhsllppPFPEl+suuhchhpslssasWslpt.hlsssGFl-alLDcpoEpsK-hc.tKapll+plsp..p....usslhucsphl....+LpcYlp.GPaahps.sssAsp..ss-	.....................................................................................................................................................................................................................l..hh..................ph.........l.hs.L..p..sp...tlp.hsh.t.......ltph....pp...t..t....s.....ht..hh.s...p......l....h...ll.hl.tt...php.l.sptA..hphltpls.t..p.t.............th.p...lh....h......htpLtpl.h.tp...ss....h.h.R.......h.R..lhp................l....lspl.sphS.......p...h.p.hhhp.t..s..l..ls.llp....plps..cDhLl...p...hssh-hlspL.u....ppps............h....pal...p.p.slhptl....sshl.t..ptss.............tt.hhl..uhh.........................................t..h.............h..h.......h.............h.......h................s..........u.hp.shu...h.s.ts..puh.hl...........h...h..h....t.........t...hpshs.h.........................................................hht.ht......................h.t.....pps..-hp.s.hthh..h.........h............h.......t........t.hhphhhs.t.t...............h+hthh..h..............................h..........thp.hht.G.a................................................................................................................................................	1	59	77	114
+10341	PF10509	GalKase_gal_bdg		Galactokinase galactose-binding signature	Finn R, Coggill P	anon	PROSITE_PS00106, Pfam-B_2277 (release 22.0)	Domain	This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2], and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6 [3]. This domain is associated with the families GHMP_kinases_C, Pfam:PF08544 and GHMP_kinases_N, Pfam:PF00288.	20.20	20.20	20.20	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.79	0.72	-4.69	183	3091	2009-01-15 18:05:59	2008-02-27 17:35:22	4	16	2627	25	790	2189	438	51.10	45	12.61	CHANGED	tptFpptF....upp..sp..h.hhpAPGRVNLIGEHTDYNsGhVLPhAIshsshsu.sphp	..................p.phFtphF.....G.t......ss......h.shtAPG.......RVNLI.......G.EHTDYNsGaVlPsAI.shsThsust.R............	0	262	473	658
+10342	PF10510	PIG-S		Phosphatidylinositol-glycan biosynthesis class S protein	Buljan M, Coggill P	anon	TreeFam_TF105857	Family	PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI [1]. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U.  The exact function of PIG-S is unclear [2].	20.40	20.40	21.50	20.60	19.30	20.30	hmmbuild  -o /dev/null HMM SEED	517	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.50	0.70	-5.83	32	374	2009-09-10 22:53:53	2008-02-27 17:48:41	4	11	269	0	266	360	2	405.30	24	84.23	CHANGED	luahhl..hlhl.......................GlPlWa+TTol...YRAsLPhpplpshspth.........................psplphslslhlpssp...........h.ssttcpl.pplpctlss.....p...t.taplplphhpts.pppppht....t.........................h..tt..th.phphp.tspph.lhhspssl..sp.....lsthlushLh...........tplhptchtplsplhsstshttsp........................................ulpaussYcl.sFSLLssssp..shs..WDI-........sulcc.YhpPllptLuslsNFol-oQl.Yaushs...hpshhspt.t............................................................................................................aslsps-LuphINssEhsLsss...hspsPs............lNFllYl.......Pss..ppuPlhlppps..............ssuFllPQWGGVhlhN.s..........tpp.sh.......lscptLtssh.sFspQLhpLLGlspsss.......................ssshcl-sLhRhpshpsltpussTLtSLs+LscslspIsIPcpVtspVpp..ulptlpp.uhctLpts.......phppALthuppAhshuE+AFF-t.sMltQhYFPsEHKhAVYlPLhuPlslsllhull+.hKchppcp+p	.................................................................................................................................................................hhhlhhhlGlPhWapoTph...aRs.LPhpth.tht...................................h....h.l.l...t...................tptl...t..h.p.hp.....................hphph...........t...............................................................t.....t........h...hhhs...tt.....t...............ls.hhtt.lh..........................hht....th.h..hh...s.t...t.....................................................................hsht.s.thcl.shoLhssssp.....p...W-lp...................t.slpp.alpPhlp..tlusls..NF.o....lcoQl.has.hs.......hpsp.........t............................................................................................................hh.l...p..psLsth...l.ss...sE.h..Lsss..........hs.ts.s.................................................................lpallal..........P.....tpsPlhlt....ttp........................ssuah.P......pWGulhlhN.s................tt..h.................hsp.th....hh.hFh.s..pLh.Lh...Ghsps........................................h.hclstlhhhpshp.lhpussTLtSLspLh.tpls..phsI.ppluppV.p.......ulttlpt.shp.ltts..........................................htpuh.h.up.A.t.uEpAFF-..ohlt.hYFPp-pKhAlYlPLhhPhslsllhuhhp.hhth................................................................................................	0	103	157	222
+10343	PF10511	Cementoin		Trappin protein transglutaminase binding domain	Finn R, Coggill P	anon	PROSITE_PS00313	Family	Trappin-2, itself a protease inhibitor, has this unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase [1]. This domain contains several repeated motifs with the the consensus sequence Gly-Gln-Asp-Pro-Val-Lys, and these together can anchor the whole molecule to extracellular matrix proteins, such as laminin, fibronectin, beta-crystallin, collagen IV, fibrinogen, and elastin, by transglutaminase-catalysed cross-links. The whole domain is rich in glutamine and lysine, thus allowing and transglutaminase(s) to catalyse the formation of an intermolecular epsilon-(gamma-glutamyl)lysine isopeptide bond [2]. Cementoin is associated with the WAP family, Pfam:PF00095, at the C-terminus.	22.30	22.30	22.30	22.30	21.40	22.10	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.26	0.73	-6.52	0.73	-3.99	21	190	2009-01-15 18:05:59	2008-02-28 13:12:49	4	14	25	1	41	164	0	16.90	61	22.81	CHANGED	GQDsVKGph.lKGQDss	.GQDsVKGpsPVKGQDss...	0	2	2	2
+10344	PF10512	Borealin		Cell division cycle-associated protein 8 	Buljan M, Coggill P	anon	TreeFam_TF101077	Family	The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters [1].	19.50	19.50	19.70	23.70	19.00	19.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.66	0.71	-4.17	9	119	2009-01-15 18:05:59	2008-02-28 14:20:31	4	3	68	2	73	116	0	115.60	33	42.21	CHANGED	RhSRuphtTPhsup...htsShs+.hshhTP.......+hsspss.hshLRpsphuEslYSho..GSPl.Ass...c.hslslPItsG....cshcL.As-l-oh.lppLDscsLppIKpLpspLspIssphc	................................................S+tthhTPtssp........thS.hs.p.psh...hTP...............+hs..sps..tts.h.L.R...pPtsuEhlhohu..GSPL.sss...............cph.lslPlssG.....csh+L...ss.-.lpph...slt..pLDs....csLspIKpLpspLtplss.h.................................	0	17	20	49
+10345	PF10513	EPL1		Enhancer of polycomb-like	Mistry J, Wood V	anon	Pfam-B_3033 (release 22.0)	Family	This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes [3].	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.34	0.71	-3.99	83	1066	2009-01-15 18:05:59	2008-02-28 14:26:12	4	25	277	0	649	973	5	150.90	23	16.50	CHANGED	hRh++lshp....ptl.lhp..t.c-l.shpt..............................................................................t.t..p.............p..ptplpthhstsp..........................................lPpPshp....hp...hpp.hsst.atpPp.sYl+ap.................................s--hs................tscYDhD-cDptWLcph...........................Npc...............t.shp.................lopppFEhlh-chE+p	......................................................................................................................................................................................................................................................................t....th.s......p.h.lhp....p-h.s.....................................................................................h..tp.......................t..ccp.hptshpttp..........................................................................................................................................lPpPphc...........lp.......hpp..ss....a.p..Pp..pa.h.+ht...ttt................................................st-hs............................tscYDhD-cD...ttW.Lc.h.h..............................................................................Npc.................................................t.h...t................................................lstppFEhlh-clE+...........................................................................................................................................................	0	168	282	466
+10346	PF10514	Bcl-2_BAD		Pro-apoptotic Bcl-2 protein, BAD	Buljan M, Coggill P	anon	TreeFam_TF102001	Family	BAD is a Bcl-2 homology domain 3 (BH3)-only pro-apoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors [1]. Binding of BAD to mitochondria is thought to be exclusively mediated by its BH3 domain. Membrane localisation of BAD mediates membrane translocation of Bcl-XL. The C-terminal part of BAD is sufficient for membrane binding. There are two segments with differing lipid-binding preferences, LBD1 and LBD2, that are responsible for this binding: (i) LBD1 located in the proximity of the BH3 domain (amino acids 122-131) and (ii) LBD2, the putative C-terminal alpha-helix-5 [2]. Phosphorylation-regulated 14-3-3 protein binding may expose the cholesterol-preferring LBD1 and bury the LBD2, thereby mediating translocation of BAD to raft-like micro-domains [3].	25.00	25.00	35.70	35.70	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.06	0.71	-4.29	4	66	2009-01-15 18:05:59	2008-02-28 16:01:59	4	2	34	2	24	48	0	140.30	56	92.03	CHANGED	MFQIPEFE.SEQEDuSpsDRGLGPS.oGDtP.G.tKpahpAPGLLtphspQQ.GQssusSHHGGsGshEhRSRHSSY.AGsE-DEtM.tE-.uPFRGRSRSAPPNLWAAQRYGRELRRMSDEFcsSF.KGLPRPKSAGTATQMRQSsSWTRhlQSWWsRNLG+GuSsPSQ	.........................................................................MFQIs-.-.oEpEDs........SsspRuLuPp.ststs.u.....htsPuhhhtssHpQ.tp..ssupsH+G.Gs.ushEhR..SRH..S.......Sh.uG..s--....DEuh.tEE.uPFRGRSRSAPPNLWAApRYGRELRRMSDEFpsSF.K.G.LP.RPKSAGTAoQMcQSsSWp+hh.uhasRp.ucGtstPs..............................	0	1	4	9
+10347	PF10515	APP_amyloid		beta-amyloid precursor protein C-terminus	Finn R, Coggill P	anon	PROSITE_PS00320, Pfam-B_2082 (release 22.0)	Family	This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, Pfam:PF02177, further towards the N-terminus.	19.90	19.90	20.50	20.20	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.50	0.72	-3.71	9	380	2009-01-15 18:05:59	2008-02-28 17:07:07	4	21	99	18	118	341	0	51.60	67	8.22	CHANGED	lIllullhl+.R+shusluHGhVEVDss....hoP...EE++LscMQppGYENPTYKaaE	.............................................................VIVIoLVML+.K+Q...Yso.I.pHGlVE.VDsh....lTP......EERHLsKMQppGYENPTYKahE........	0	21	30	66
+10348	PF10516	SHNi-TPR		SHNi-TPR	Mistry J, Wood V	anon	Pfam-B_14727 (release 22.0)	Repeat	SHNi-TPR family members contain a reiterated sequence motif that is an interrupted form of TPR repeat [1].	20.70	20.70	20.70	20.80	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.33	0.72	-4.71	25	326	2012-10-11 20:01:02	2008-02-29 10:58:00	4	17	229	0	195	330	10	37.60	37	7.83	CHANGED	A-sashLGElSLEsEpFsQAspDhcpuLpL+pplhssc	..........Apsa.tLGElSlEuEpaspAlpDappsLslppphh.sc..........	1	65	104	158
+10349	PF10517	DM13		Electron transfer DM13	Iyer L, Mistry J	anon	Manual	Domain	The DM13 domain is a component of a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins [1].  It contains a nearly absolutely conserved cysteine, which could be involved in a redox reaction, either as a naked thiol group or through binding a prosthetic group like heme [1].	25.00	25.00	25.60	26.40	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.33	0.72	-3.67	66	749	2009-01-15 18:05:59	2008-02-29 15:11:02	4	14	535	0	284	582	71	101.70	27	42.30	CHANGED	G....pFpt..pss...HhspGplpl....supphlthp.shss...G...PDh+laLuss......tsptsh.h.psph..lplGsl.Ksa..sshhhslPsslclscassVllWC-pFu.hhuuAphp	.........................pFpt..pss.....ct.s.p.G.pspl..........hsucp.hlh.t.sacupt.G...PDhalaLsps........................sshcpt..........tclu....l....ct....ppc..shsLPps.l...c.l..sc..aspVslaCcchps..FGuApl.....	0	108	166	254
+10350	PF10518	TAT_signal		TAT (twin-arginine translocation) pathway signal sequence	Bateman A	anon	Bateman A	Motif	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.85	0.74	-7.47	0.74	-3.49	64	1505	2012-10-02 00:19:25	2008-02-29 15:28:33	4	168	868	0	484	1326	535	25.60	34	5.54	CHANGED	phoRRshL+uuuusuussshuussss	....loRRsFLKuuuusuAusuluush.............	0	160	342	422
+10352	PF10520	Kua-UEV1_localn		Kua-ubiquitin conjugating enzyme hybrid localisation domain	Buljan M, Coggill P	anon	TreeFam_TF106147	Domain	This domain is part of the transcript of the fusion of two genes, the UEV1, an enzymatically inactive variant of the E2 ubiquitin-conjugating enzymes that regulate non-canonical elongation of ubiquitin chains, and Kua, an otherwise unknown gene. UEV1A is a nuclear protein, whereas both Kua and Kua-UEV localise to cytoplasmic structures, indicating that the addition of a Kua domain to UEV confers new biological properties. UEV1-Kua carries the B domain with its characteristic double histidine motif, and it is probably this domain which determines the cytoplasmic localisation. It is postulated that this hybrid transcript could preferentially direct the variant polyubiquitination of substrates closely associated with the cytoplasmic face of the endoplasmic reticulum, possibly, although not necessarily, in conjunction with membrane-bound ubiquitin-conjugating enzymes [1].	21.70	21.70	24.30	23.40	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.44	0.71	-4.62	21	202	2009-01-15 18:05:59	2008-02-29 16:08:18	4	3	148	0	125	190	17	167.40	46	60.55	CHANGED	hlhADFsSGlsHWusDTWGos-pPllGp.aIcsFREHHlcPpsIT+HDFlEsNussshsplssLhhhshphhhpsss.....h.......shps...FlhshshalshTNQlHKWSHthhu.lPshVhhLQchcllLsR+cH+hHHpuPa-shYCIToGWLNhsL-clsFW+phEtllphhTGhpPRucD	.....................................lhADFhSGlVHW......uuD...TWGSs-hPllGcsFIRsFREHHlDPouI...TRH....D.FIETNGDNs.....hlslhsLhhhsaphhstss.t....th...h..............shps.Flhshh.lalshTN........QIHKWSHohhu..LPtaVhhLQch+lILPR+HH.R.lHHluPH-oYaCI..T...TGWlNhsL-....ph....tFapthE.llphhTG.pPRspD..................	1	45	66	98
+10353	PF10521	DUF2454		Protein of unknown function (DUF2454)	Mistry J, Wood V	anon	Pfam-B_82729 (release 22.0)	Family	A Schizosaccharomyces pombe member of this family is known to interact with Tel2.  Tel2 is a component of the TOR complexes [1].	22.30	22.30	22.30	22.60	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.79	0.70	-5.40	29	199	2009-01-15 18:05:59	2008-02-29 16:15:39	4	5	178	0	142	207	0	256.50	20	52.36	CHANGED	cllhsLusasss...ppshooppspshsptllp...............sss.hphlpp..........hLhppl+Phhh+s............p..thottG+.............shpP..h.tht.s......t.psWKhssshtshslsWhlh..pthspspls....sphshllPslLsLlDDp...ssshKhpGspLLpplLp.h.psp.........LppTsLssVap-ulhspLh.lPshostspolpLlpssaPsLhsLh.h.......................tsspsp.......phtplschlpcsILsshtthps...............a.pLsphLlppl.thltp.LGhpsstaLpcll.hltp.hlpsPhhsth	........................................................................................h..h.has.....p.sWs...o.ts..tphsttlhp...................pt..tt...htp...........hlhthl+Phh.+p.......................t...............................t..............psWKpps..sht.t.shtWslt..............psspshls.......................pph.hllPs.hLsllDDh...psphKhtGlphLpplltps.tsp........................LtppshspVh.culh.s.pLh........spshpLlphshsslhsLh.h...................................psstt.........c.pphschltphlLss.hthttp...................tlpph.hhpp.ls.hlpp..lGl.hss+aLpclh.hl.t.hlps..h...................................................................	0	37	72	109
+10354	PF10522	RII_binding_1		RII binding domain	Bateman A	anon	Vijayaraghavan et al. Mol Endocrinology 13(5):705-717 (1999)	Motif	This domain is found is a wide variety of AKAPs (A kinase anchoring proteins) [1].	14.40	14.40	14.40	14.40	14.30	14.30	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.55	0.76	-6.60	0.76	-2.98	14	161	2009-01-15 18:05:59	2008-03-03 10:00:48	4	11	27	0	47	185	0	18.00	44	1.91	CHANGED	plcphAsplVptVIppAh	.pLEatAspLlptlIQpAh...	2	4	4	9
+10355	PF10523	BEN		BEN domain	Lakshminarayan I, Bateman A	anon	Lakshminarayan I	Domain	The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription [1].	21.30	21.30	21.40	21.60	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.34	0.72	-3.92	70	842	2009-01-15 18:05:59	2008-03-03 10:50:14	4	14	114	0	412	780	0	78.60	21	21.22	CHANGED	pphsptLlptlFscphhsp..shssphp..................t.sp..tLDsptlphI+phlppthshpp.......phWt.pshptls..phhpstpppt	........t.phsppLLthlFscph.hssp.shsGphpp................ttss+p.tLDspclphl+.....palpthhsspc............p.a..phtppls..phhpp..p..h.....................................	0	71	102	212
+10356	PF10524	NfI_DNAbd_pre-N		Nuclear factor I protein pre-N-terminus	Finn R, Coggill P	anon	PROSITE_PS00349	Family	The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organisms. The N-terminal 200 residues contains the DNA-binding and dimerisation domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerisation-ability and the stimulation of adenovirus DNA replication [1].	21.50	21.50	22.20	22.90	20.80	19.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.18	0.72	-4.36	7	412	2009-01-15 18:05:59	2008-03-03 11:18:10	4	5	78	0	136	328	0	42.20	88	9.29	CHANGED	sh...pQ--htPFlEtLLPaV+A.AYsWFpLQAAKR+aaKcH-K	.....s...shhQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEK...	0	19	35	75
+10357	PF10525	Engrail_1_C_sig		Engrailed homeobox C-terminal signature domain	Finn R, Coggill P	anon	PROSITE_PS00033, Pfam-B_11539 (release 22.0)	Domain	Engrailed homeobox proteins are characterised by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins [1].	21.70	21.70	22.50	21.70	19.90	21.60	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.13	0.72	-7.54	0.72	-4.82	23	236	2009-01-15 18:05:59	2008-03-03 14:14:06	4	1	120	2	106	226	0	30.00	64	10.64	CHANGED	AoGs+NsLALpLMAQGLYNHST.sshsccp-sp	....AoGtKNsLALpLMAQGLYNHST.sshppcp-p...............	0	27	36	68
+10360	PF10528	PA14_2		GLEYA domain	Linder T, Bateman A	anon	Linder T	Domain	This presumed domain is found in fungal adhesins and is related to the PA14 domain.	19.70	19.70	19.70	20.20	19.50	18.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.37	0.71	-4.11	8	132	2012-10-02 01:24:23	2008-03-03 17:31:24	4	25	47	1	112	246	18	116.20	24	15.87	CHANGED	shsIVaQhahhs.tT.sTYTLsV.sNsDDlFaGWFGs.KAhSGWSss.......NYDsYAhWp.......GppuhushssssLssGpalPlRFlhANGuuhGuFsFsFsussosslssT........oYsY...TuTC	......................hsl.hp.GYFhsspo.GsYoFsl........p..sDD...hshlhh.Gs......sA......as.s.....hs.ps......................Nhsh..hsh..h.........ssss..s..p.s..sh..shpL..puGhYYPlRl.ha.sNt.s.ssushsh.shpsP.sGshhhs......................t...................................	0	18	59	104
+10361	PF10529	Hist_rich_Ca-bd		Histidine-rich Calcium-binding repeat region	Finn R, Coggill P	anon	PROSITE_PS00328	Repeat	This is a histidine-rich calcium binding repeat which appears in proteins called histidine-rich-calcium binding proteins (HRC). HRC is a high capacity, low affinity Ca2+-binding protein, residing in the lumen of the sarcoplasmic reticulum. HRC binds directly to triadin. This binding interaction occurs between the histidine-rich region of HRC and multiple clusters of charged amino acids, named as the KEKE motifs, in the lumenal domain of triadin. The region in which this repeat is found in many copies is long and variable but is the acidic region of the protein. There is also a cysteine-rich region further towards the C-terminus [1]. HRC may regulate sarcoplasmic reticular calcium transport and play a critical role in maintaining calcium homeostasis and function in the heart. HRC as a candidate regulator of sarcoplasmic reticular calcium uptake [2].	17.50	9.00	17.50	9.10	17.40	8.90	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.44	0.73	-6.52	0.73	-3.76	25	173	2009-01-15 18:05:59	2008-03-04 12:26:43	4	10	17	0	51	157	0	15.30	56	11.48	CHANGED	HRH..RGHc-E-D-D-D	.....HRH..pGHccEED-Dss.....	0	6	6	6
+10362	PF10530	Toxin_35		Toxin with inhibitor cystine knot ICK or Knottin scaffold	Finn R, Coggill P	anon	PROSITE_PS60029	Family	Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot (ICK) structural motif or Knottin scaffold. The four disulfide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7. CSTX-1 is the most important component of C. salei venom in terms of relative abundance and toxicity and therefore is likely to contribute significantly to the overall toxicity of the whole venom. CSTX-1 blocked rat neuronal L-type, but no other types of HVA Cav channels [3]. Interestingly, the omega-toxins from Phoneutria nigriventer venom (another South American species also belonging to the Ctenidae family) are included as they carry the same disulfide bond arrangement. suggested that CSTX-1 may interact with Cav channels. Calcium ion voltage channel heteromultimer containing an L-type pore-forming alpha1-subunit is the most probable candidate for the molecular target of CSTX-1 these toxins [3].	25.00	25.00	27.80	30.10	20.60	24.70	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.80	0.72	-6.97	0.72	-3.86	6	67	2009-09-11 14:32:54	2008-03-04 12:49:05	4	1	6	0	0	71	0	26.30	76	26.11	CHANGED	CIs++cSCppD.++GCC....ahhoCsC	CIPKHHECTSN.KHGCCRGshFKYKCQC	0	0	0	0
+10363	PF10531	SLBB		SLBB domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.64	0.72	-4.08	139	11758	2012-10-03 10:59:06	2008-03-04 15:21:41	4	110	4407	39	3040	9399	3756	52.50	24	14.22	CHANGED	hlslsGp.Vpc.....Pushclth..Gsslp-llph..uGGhstp.ut.......t..........sGshhshs	.......................htlsGc.Vpp......P.G.h.h.plsh......G.......h.........s...lt..-hlpt...AG.Ghsps..up..............p...............st......h..............................	0	1080	2052	2579
+10364	PF10532	Plant_all_beta		Plant specific N-all beta domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Babu and colleagues [1]. It is found associated with the WRKY domain Pfam:PF03106.	21.60	21.60	22.00	33.00	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.35	0.71	-4.01	10	22	2009-01-15 18:05:59	2008-03-05 11:41:14	4	4	3	0	1	22	0	105.40	36	16.50	CHANGED	pKlulDEossKLKLSYhsh.spsp..REsYIsDDEDVhlYLTss-pEuhRsVLHVEllsc.t.s-ch.EQlshV-R+..SSlGpNasplsstsc-h..csssshhhsE.......ssEsllEs-sp	........pKlulDEsshKL+LSY....spsc..REsYIsDDEDVhlaLTpscpcuhhsVLHVE.lst.t.sEch.EplShs-t+..SSVGhNhtc.ss.p-.h..c.stshh.s-.......tsEsllt.c.......................	0	0	0	0
+10365	PF10533	Plant_zn_clust		Plant zinc cluster domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This zinc binding domain was identified by Babu and colleagues and found associated with the WRKY domain Pfam:PF03106 [1].	20.60	20.60	20.90	20.70	16.40	20.10	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.76	0.72	-4.32	21	226	2009-01-15 18:05:59	2008-03-05 11:44:15	4	2	43	0	90	230	0	45.10	53	14.48	CHANGED	+++Csttspsputt....suuuu+CHCSK+.RKt..RlKRslRVPAISuKlAD	................+++Cpst.spstsp.........suuuG+CHC..S.K+..R......K...Rl...KRoIRVPAISs.KlAD........	0	11	54	73
+10366	PF10534	CRIC_ras_sig		Connector enhancer of kinase suppressor of ras	Finn R, Coggill P	anon	PROSITE_PS51290	Domain	The CRIC - Connector enhancer of kinase suppressor of ras - domain functions as a scaffold in several signal cascades and acts on proliferation, differentiation and apoptosis.	22.00	22.00	22.90	22.30	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.04	0.72	-3.93	9	212	2009-01-15 18:05:59	2008-03-05 11:48:43	4	14	49	1	128	176	0	92.00	52	12.49	CHANGED	sL+oLspKLpAus+sLQshIpuRh+ssu.-utsopchPschLsuVV-LItAA+uLLuWLsRh.FotloDaoss+.cIhpLChELsssVpccssss	.........................NL+oLscKLpAuu+NLQNaI..suRR+...ustYD.G....psS..+..Kh....PNDFLTSVV-LIuAAKuLLA....WLDRsPFsulsD.aSlo+NpllQLCLELTTlVQpDCsV........	0	10	17	69
+10368	PF10536	PMD		Plant mobile domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Babu and colleagues in a variety of transposases [1].	24.00	24.00	24.10	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.50	0.70	-5.46	44	1219	2009-01-15 18:05:59	2008-03-05 12:39:04	4	78	27	0	764	1162	0	222.00	17	35.00	CHANGED	uhuhhtsls....t..phphDps..LlsuLs-+WpsETpTFhhPhGEhTlTLpDVshLhGLsltGp......sVsushssp....hpch.......htchhthp.t.....................................................tphpppss.phs.Wlpphh....thssp.....................hpptAFLlhhluthlFss...pssptlshthh.slstslsp.....ssphuhGsAsLAhLYppLs....pustps............ssslsGshh...LlQlW...saERhthh....RP...............................p.t...h..............................................ps..............Ph..........sthWps...p.....psps.............hppth.........-t.p.sph.WpPY......spshttt....hhst.s.....................ppth......shhp..pss..L.l.............sh.......s......tlEhahPpRVhRQ.FGhtQs.lP......hph......hphhtp...tshtsastphtsh...h..t.tts..sp...........stYhcWatp	............................................................................................................................................................................................hs.....sh.-h..lhth......................................................................................................................................................................................................................................................................h...h............hsht...h......h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	15	235	306
+10369	PF10537	WAC_Acf1_DNA_bd		ATP-utilising chromatin assembly and remodelling N-terminal	Finn R, Coggill P	anon	PROSITE_PS51136	Domain	ACF (for ATP-utilising chromatin assembly and remodelling factor) is a chromatin-remodelling complex that catalyses the ATP-dependent assembly of periodic nucleosome arrays. The WAC (WSTF/Acf1/cbp146) domain is an approximately 110-residue module present at the N-termini of Acf1-related proteins in a variety of organisms. The DNA-binding region of Acf1 includes the WAC domain, which is necessary for the efficient binding of ACF complex to DNA.	25.00	25.00	27.20	25.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.27	0.72	-3.85	28	339	2009-01-15 18:05:59	2008-03-05 13:56:12	4	46	223	0	226	350	0	96.40	36	8.79	CHANGED	ccVahlptTpEhFpsY--Yh......pRhshYppchaoCc.............lTG+SsLTahEALcSE..................ccttcplcp.FPptL+pPlLchlp.aspho+l-pLV-claphhKscaFsGEpV	.............pVahh..TtEhFpsY-..-..ah......pR......h....h...hsp...........plWoCp.............lTG+..ssLTa.EALcSE........................p.cst.cplpp.FPp.LctPlLchlp.asph.o...pLccL.......s.........-p.l............ath....h+scaasGEpV.....................................	0	67	116	180
+10370	PF10538	ITAM_Cys-rich		Immunoreceptor tyrosine-based activation motif	Finn R, Coggill P	anon	PROSITE_	Domain	Signal transduction by T and B cell antigen receptors and certain receptors for Ig Fc regions involves a conserved sequence motif, termed an immunoreceptor tyrosine-based activation motif (ITAM). It is also found in the cytoplasmic domain of apoptosis receptor.	25.00	25.00	28.30	27.30	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-6.84	0.72	-4.39	6	300	2009-01-15 18:05:59	2008-03-05 14:30:42	4	5	137	0	0	316	0	24.00	71	2.81	CHANGED	+pGCYRTLulFRY+SRCYVGLVWC	....sGCYRTLsLFRYKSRCYIhThWs.	0	0	0	0
+10371	PF10539	Dev_Cell_Death		Development and cell death domain	Finn R, Coggill P	anon	PROSITE_PS51222	Domain	The DCD domain is found in plant proteins involved in development and cell death. The DCD domain is an approximately 130 amino acid long stretch that contains several mostly invariable motifs. These include a FGLP and a LFL motif at the N-terminus and a PAQV and a PLxE motif towards the C-terminus of the domain. The DCD domain is present in proteins with different architectures. Some of these proteins contain additional recognisable motifs, like the KELCH repeats or the ParB domain.	27.80	27.80	27.80	31.50	27.40	27.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.70	0.71	-4.59	10	245	2009-01-15 18:05:59	2008-03-05 14:41:54	4	20	39	0	127	228	2	119.10	44	24.57	CHANGED	LGGsIFsCNssThcECac+pLFGLPu+ahsaV+sIKPGLsLFLFNYss+pLHGIFEAoSpGthNI-spAatspt..s........opaPAQ....VRh+lthpChPLsEspF+ssIhpNYhs.......ss..KFRaELo+sQspcLlcLF	........................uGhIFhCNspThpEshc+pLFGLPtp.htc...V.c.sIcPGhsLFLYsass+pLaGlFEAsS.GGhNI.-PsAapspt.............ppFPAQ....V+hph.ct..Ch..PL...EspF+ssl.....pahs.......t...KFphELshtpshpLhpLF..............................	0	20	76	103
+10372	PF10540	Membr_traf_MHD		Munc13 (mammalian uncoordinated) homology domain	Finn R, Coggill P	anon	PROSITE_PS51259	Domain	Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical.	29.10	29.10	29.10	29.10	28.50	28.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.37	16	574	2009-01-15 18:05:59	2008-03-05 15:06:33	4	32	217	2	337	493	0	126.90	35	9.55	CHANGED	-sslpPLMDaLDspLulhscsh.KpshpRlLp.tLWchVlsplcctl..s..pp........................................................htpp+sLosppsshlphsLpslcpaFHA......pGpGLp.........................hshLp+oschpsLcptLpLaspsT-pLIcpF	......................................................-ssltPLh-a.....LDs.sLslhspshpcss..h.p+VLp.cLW+h..Vlssh-chl...lPshsct..........................................................................................................ppt+sLoscpsshlchsLcsl.p.paFHA......tG..s..G.L..........................hshL.KSschp...........sLchtLpLYspsT-pLIcpa....................................................	0	83	129	238
+10373	PF10541	KASH		Nuclear envelope localisation domain	Finn R, Coggill P	anon	PROSITE_PS51049	Domain	The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localisation domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes [1]. During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere [2].  SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics [3].	23.00	23.00	23.60	26.70	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.03	0.72	-4.12	20	319	2009-12-22 14:12:53	2008-03-05 15:18:45	4	33	80	2	156	310	0	56.40	58	1.68	CHANGED	altRlhRsALPlQ.LLLLLLlslAsLlP.......hpt--aoCshsNNFARSFpPMLRYs......NGPPP.........h	...........alhRVlRA.ALPLQ.LLLLLLlsL.ACLlP........sEEDYSCshuNNFARSFaPMLRYs......NGPPPh...	0	26	37	87
+10374	PF10542	Vitelline_membr		Vitelline membrane cysteine-rich region	Finn R, Coggill P	anon	PROSITE_PS51137	Domain	In Drosophila melanogaster the vitelline membrane (VM) is the first layer of the eggshell produced by the follicular epithelium. It is composed of at least four different proteins. VM proteins are similarly organised with a central highly conserved 38-amino acid domain which is flanked by unrelated regions. The domain contains three highly conserved cysteines.	20.30	20.30	20.80	26.10	17.00	16.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.06	0.72	-4.33	2	82	2009-01-15 18:05:59	2008-03-05 16:08:28	4	1	15	0	37	86	0	36.90	75	25.87	CHANGED	uh.APPCPpNYLFSCQPNLAPsPCut.APuYGSAGAYo	.....SIPAPPCPKNYLFSCQPsLsPVPCS...A.P..A..s.SYGS.AGAYS.....	0	5	5	21
+10375	PF10543	ORF6N		ORF6N domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.73	0.72	-3.95	60	807	2009-01-15 18:05:59	2008-03-05 16:34:40	4	9	514	0	115	705	44	86.90	32	37.57	CHANGED	p.plhclRGp+VhhsppLAclYss-ocplppshpRNt.......cRFs.scahFpLstcEhcp...l+sphs..............................thstpstt.hhaTEpGsshLupl	...............t..phhphps.pVhhsppLAclYGs-.spplppshpcNt.......pRFs.scahFpL.....ss..pEhcp....l.+.s.p..hsh.p...................................thut.pttt.hlaTEpGhuhhuph...............................	0	42	87	110
+10376	PF10544	T5orf172		T5orf172 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.69	0.72	-3.61	204	1694	2012-10-01 19:55:08	2008-03-05 16:40:48	4	26	830	0	930	1844	598	92.50	31	29.87	CHANGED	GhlYl.h...........tp.t..st.......hKIGhTps...lpcRlpphp..............sshshphph......hth.............h...sstcl.EphlHpphps...hcl...............cpEaFc.....ls.....hcplcp.....hlc..pht	.................................................................GhlYl.l...................ppspshsp............ph..aKIGhT........hs....lppRhcphs....................................................................sclcV.......................................................hhss.Dhpsh....EspLh.cp..Fcc....t..h..h..p.......................................t+EhFc.........Vs..........plpphh....ph........................................................................	0	747	823	896
+10377	PF10545	MADF_DNA_bdg		Alcohol dehydrogenase transcription factor Myb/SANT-like	Finn R, Coggill P	anon	PROSITE_PS51029	Domain	The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.10	0.72	-3.79	116	1496	2012-10-04 14:01:12	2008-03-05 16:45:37	4	95	82	0	954	1699	0	82.30	20	23.59	CHANGED	LIphl+ppPsLacppp..pYp......sps................t.+ppsWppluppl...s..hs....s..p.....s+p....+WpsLR...spap+ch.cphp...............tspthtspah....ahcphpFL	.............................................LIphhcppPsLas...tpp...p.ap......spp..........................t.+p...psW..p...p...lu...ppl.......s.......hs............s..pp................hpp.+aps..LR.......sp.Yp+ch.+chp..................tttthhsph.....ahcphpFL.....................................................................	0	247	332	748
+10378	PF10546	P63C		P63C domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	25.00	25.00	36.80	36.10	24.70	15.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.12	0.72	-4.05	12	137	2009-01-15 18:05:59	2008-03-05 17:02:07	4	6	134	0	16	88	3	89.00	38	30.96	CHANGED	Ih-tFlucclpPahKpFPssaYcplFRLpGhpasscssp.RPthhGphTNcllYpRLAP...tlLEEL+cpssp.ttctt+.t+hHQhLTp-IGHPcL	............IhthFlhp-s.psWpKcF..sDshYctLaRhpGls..tcpss.+PhlauhloschIYs.lhP...plhs-lKtptsh.........tpKhHQaLssD.G........	0	5	8	11
+10379	PF10547	P22_AR_N		P22_AR N-terminal domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	25.00	25.00	27.80	27.70	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.66	0.71	-4.28	13	394	2009-01-15 18:05:59	2008-03-05 17:05:07	4	6	279	0	35	249	7	115.70	53	47.21	CHANGED	lssp..sVsFpGppL.l..sVppsG..psYsuMKPIVEuhGLuWpSQapKLhpscstsshlcIsh.VuuDGKpRcMlClPL+KLsGWLhoIsPsKVRPElRDKlIpYQcEChcVLa-YWp.pGtA.....R	............hshhsVPFHGss..L.a..lVs.aN..G..EPY.VPMKPlVpGMGL...s...Wp...S...Q...hsKL.+pRFts.sls.E....Is.........h..VA..........p.D......GKpRpMlsLPLRKLsGWLpTI....NP....N...K.V....+.PE.........IR-KVIpYQEECDDVLY-YWT.KGhVhNsR................	0	8	21	32
+10380	PF10548	P22_AR_C		P22AR C-terminal domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1]. It is found associated with Pfam:PF10547.	21.00	21.00	21.10	21.30	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.28	0.72	-4.11	16	459	2009-01-15 18:05:59	2008-03-05 17:07:46	4	11	251	0	11	261	0	73.00	45	29.70	CHANGED	pcp...ashpFT-pELppLsWLahuhp+spshhpplh.sLctlsSshusplYuhuhEYtpshcps+plLp+hstchc	..............pc+hssphoAcEhsoLVWLWpausRuQsLh+cLYPALKpIpSsYoG+sYDhuaEasYllshAR-VLlpcTcclD......................	0	2	6	9
+10381	PF10549	ORF11CD3		ORF11CD3 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	25.00	25.00	26.70	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.72	0.72	-4.24	9	414	2009-09-11 15:21:10	2008-03-05 17:11:40	4	6	250	\N	11	158	0	56.50	43	32.33	CHANGED	phohppphNphstEacpcKslAShsG+sLscW.+hcKPhL.AclcphcpchQlplshh	.......ShppEhNtsCt-hc+-KslAShsuptLNcW.+hsKPsllu+IcpLtppuQlhlshh..............	0	3	5	8
+10382	PF10550	Toxin_36		Conantokin-G mollusc-toxin	Finn R, Coggill P	anon	PROSITE_PS60025	Domain	The conantokins are a family of neuroactive peptides found in the venoms of fish-hunting cone snails. They possess a high content of gamma-carboxyglutamic acid (Gla) (4-5 residues), a non-standard amino-acid made by the post-translational modification of glutamate (Glu) residue. Conantokins are the only natural biochemically characterised peptides known to be N-methyl-D-aspartate (NMDA) receptor antagonists.	25.00	25.00	26.70	26.00	19.40	18.50	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.13	0.74	-6.50	0.74	-2.29	3	3	2009-09-10 23:18:32	2008-03-05 17:15:11	4	1	3	1	0	3	0	14.70	76	19.21	CHANGED	GEEElQKMspELhRE	GEEEVAKMAAELARE	0	0	0	0
+10383	PF10551	MULE		MULE transposase domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Babu and colleagues [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.32	0.72	-3.82	126	2654	2012-10-03 01:22:09	2008-03-05 17:40:22	4	142	229	0	1688	6089	517	90.00	18	13.95	CHANGED	us.....ah....h...........hhs.......hhGhst......phh....l........uhslh.ss.............Estcs.ap...hhhp.....shp..psh................hlloDtppulhpAlpp..la............Pt..sp..pphChhHlh...csht	................................................................................................hhuhstpt.....phh....sh........u.hs.l.l..ps.......................................Estcs..at...........ahhp..................................................phh....phhst...........p...sh..sllsD.p.pt...u....hhpAlpp..sa............Pp.....sp....pthCh.hHlhpsh.h...............................................	0	642	1072	1371
+10384	PF10552	ORF6C		ORF6C domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	21.90	21.90	21.90	21.90	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.26	0.71	-4.36	23	471	2009-01-15 18:05:59	2008-03-06 12:49:20	4	10	383	0	34	350	3	108.30	23	46.84	CHANGED	ptltlhhps.cphccclpplcpclpcLc....pshsLhss-scplp+pVpppVsphLGG+tosAYpc..l+pKlapDIapplK+pFsVsoYssI++Kch-pAhchl.ssapssp..shptcIp	.................................................h.hhhps..phppphpp.lcpc.......lptLc..................pp.sl...stsptp....plpptlpp+Vh....thhs.Gh.t..s.............sap.........c....hppp...lapp........h.hppl....KctFsV.spYspl.+pca-cAlpal...ppWpPsh..tht.pI.................	0	7	24	29
+10385	PF10553	MSV199		MSV199 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	21.10	21.10	21.50	22.80	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.79	0.71	-4.29	16	37	2009-01-15 18:05:59	2008-03-06 12:58:01	4	10	5	0	0	37	36	134.10	32	36.17	CHANGED	hlDIhp...FIctssa-hchh..hhpphWhshhs.......cpplhIosslLpaltYpsp...........app.+cs..FcchLcpNpIpa............................................pclpas-s.lpp..YsplpcEhcpls..sslspp+WlIlpscsFKhhIh+LNTpsuchIRcYYlplEcllp	...................hlDIhpFlchspaclshs..hFs.hW.slss.................ppphhlspslLcWhGYpGc...............hppQ+ps..Fp+hLcpNpIpY............................................pElshp-..lp...YsplpcElptls.ssslspp+alIhcscshKhuIMpLpTKsuchIRcYYlsLEcllp..........................	0	0	0	0
+10386	PF10554	Phage_ASH		Ash protein family	Iyer LM, Bateman A	anon	Iyer LM	Family	This family was identified by Iyer and colleagues [1]. It includes the Ash protein from bacteriophage P4.	21.80	21.80	21.80	21.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.35	0.72	-3.71	19	596	2009-01-15 18:05:59	2008-03-06 14:21:45	4	7	351	0	35	460	0	95.40	36	41.17	CHANGED	YospAstKouAGhssPphstApscA....usFh..ssths............................thplM..........VupAGtPpuhPsSh....................loGhusPVphsT.clsss.G..GshhphshEAA..................hMsTl............ohspsph	.................................Ysh.AshKsuAG.hts.p.......st.cA......ssFh..shthp.......................................hhp.M..........VupAGt..spshPsSh....................hsGhusP.Vphs.T.p.clssS.G..Gs..hphhhEAA..................hMA.Th.......s.spsp....................................................................................	0	1	8	20
+10387	PF10555	MraY_sig1		Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 	Finn R, Coggill P	anon	PROSITE_PS01347 	Domain	Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (mraY) is a bacterial enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. It is an integral membrane protein with probably ten transmembrane domains. This domain is located at the end of the first cytoplasmic loop and the beginning of the second transmembrane domain.	20.10	11.30	20.10	18.00	20.00	11.10	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.95	0.74	-5.85	0.74	-4.24	64	3122	2009-01-15 18:05:59	2008-03-06 15:12:43	4	4	3072	0	644	1899	1136	13.00	74	3.72	CHANGED	KpuTPTMGGllll	..KpGTPTMGGllIL.	0	203	418	541
+10389	PF10557	Cullin_Nedd8		Cullin protein neddylation domain	Finn R, Coggill P	anon	PROSITE_PS01256	Domain	This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue [1].	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.12	0.72	-4.15	109	1474	2009-01-15 18:05:59	2008-03-11 09:11:25	4	25	308	28	994	1441	15	66.30	42	8.55	CHANGED	lpp-RphhlpAuIVRIMKsRKplsHspLlsElhpplpp...+Ftssss.IK+pIEpLI-+EYlcRs..psts	.....................tpDRphtlpA.A....IVRIMKsRKp.lsHspLlsEl..............hpQLpt...........+Fh..Pp...sshI.K.........KpIEsLI-+-YlcRscss..t..................	0	369	551	808
+10390	PF10558	MTP18		Mitochondrial 18 KDa protein (MTP18)  	Tolvanen M, Bateman A	anon	Tolvanen M	Family	This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis [1]. Overexpression studies suggest that MTP18 is required for mitochondrial fission [2].	25.00	25.00	61.10	35.40	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.83	0.71	-4.34	24	236	2009-09-11 16:45:10	2008-03-11 10:46:53	4	3	206	0	171	223	16	155.30	37	70.83	CHANGED	oslRYAu.h.Rhtp.........uYssDlGEuFRPls.shLV+uuYGVSauYlluDls...cuhKshhcscthhs..............................................................................hpchph.ssscpslaQulAShulPuFTIHolVpaSuhhhpps..+........shh.RpWsPsulGLuslPhLsa.hDcs......V-psl	.....................................................h...RYluYss-lGEuFRsls.shlV.......puuYGVuhuYlluDss..pcGhKAhhpspt.hs....................................................................................pchth...ssscphlaQulAShulPuFTIp.plsthSthhhpss......+.............shh..RpWsP..sulGLuslPhl.a.hDcsV-th........................................	0	59	93	140
+10391	PF10559	Plug_translocon	Plug_Sec61p; 	Plug domain of Sec61p	Coggill P	anon	Finn R	Domain	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [1].	22.10	22.10	22.70	22.20	21.80	21.30	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.42	0.72	-4.44	68	686	2009-01-15 18:05:59	2008-03-13 11:30:10	4	8	470	12	424	593	89	34.60	52	7.47	CHANGED	llYhlhoplPLYGl.....sssssDsFhhhRslh.AuspG	........hIFLVhs.QlPLaGI........hSocouDPFYWhRsIL.ASNRG..	0	141	242	351
+10393	PF10561	UPF0565		Uncharacterised protein family UPF0565	Coggill P	anon	UPF0565	Family	This family of proteins has no known function.	25.00	25.00	25.10	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.93	0.70	-5.53	12	182	2009-01-15 18:05:59	2008-04-16 15:38:41	4	5	101	0	127	176	0	192.10	24	72.60	CHANGED	shpl.slsGhp..pRsNsllhhtPhhp...............spp.ssptllaFsGDhpsa.pp......hppsssssp.hpasLEslAhlLsp+Fsts......HIhVl+sSph..spFSsasNFlpussh............................................GsPcp...o.sthtuhpHLhpLL.shhpclhp...t.ph..p.h......................................................................................................................................................................................s.shtchpLhLlGFSKGCsVLNQllhEhp.......................ht..ssphphhlspIsshYaLDsGaststtsalTppssLcpLupt......ulplalHsTPaQlpDshRsWI++EhcpFlchLcphuhsh	...............................................................................................................................sht..h.hl..th..t.......hhhlcs..h.....t....husapshl.ss..............................................G.s..............u...th...lh.t.........................................................................................................................................................................................................................................................h.lhGFSKGssVlsphhhEht.................................................................th....h.ht.lpthaalDsGhs.t.tsa.s..thlpthsp.........th.hhhHhTPhphts...Rshlt.E.t.h.phLt......s...............................	0	47	64	100
+10394	PF10562	CaM_bdg_C0		Calmodulin-binding domain C0 of NMDA receptor NR1 subunit	Coggill P	anon	Pfam-B_7118 (release 22.0)	Domain	This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a critical role in learning, memory, neural development, and synaptic plasticity. Calmodulin (CaM) regulates NMDARs by binding tightly to the C0 and C1 regions of their NR1 subunit. The conserved tryptophan is considered to be the anchor residue [1].	20.20	20.20	20.20	23.20	18.10	19.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.85	0.72	-7.01	0.72	-4.09	4	144	2009-01-15 18:05:59	2008-04-16 17:43:46	4	12	71	0	48	149	0	28.80	70	3.30	CHANGED	IsYK+H+shKcKphELA+pAsD+WRuNIp	.IAYKRHKDARRKQMQLAFAAVNVWRKNLQ...	0	11	15	32
+10395	PF10563	CdCA1		Cadmium carbonic anhydrase repeat	Bateman A, Coggill P	anon	Bateman A	Repeat	This domain is the cadmium carbonic anhydrase repeat unit of the beta-carbonic anhydrase of a marine diatom [1], that uses both zinc and cadmium for catalysis of the reversible hydration of carbon dioxide for use in inorganic carbon acquisition for photosynthesis (thus being a cambialistic enzyme). Compared with alpha- and gamma-carbonic anhydrases that use three histidines to coordinate the zinc-atom, this beta-carbonic anhydrase has two cysteines and one histidine, and rapidly binds cadmium [2].	20.80	20.80	21.80	30.80	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.41	0.70	-4.83	18	25	2009-01-15 18:05:59	2008-04-16 17:46:55	4	3	10	6	16	27	2	195.00	32	65.05	CHANGED	hWpuulsssssahplhs.+hshs-hD.....cssDG.s.ss..sphstP......................................+hLushh.hsspcGhRsp+h.cstsp.ss.................psGcs.pVHhsHSu...hhuCG....Ypp.ahsGhFsshs..................hssasu..GutsltsAsGV...l.slVs..-EpYhY.shlcGhhl-sctp.....................cpp.lssuauslpaplDtpsahIoAuu	.............apuuhssVNlHaHlGsEHhShG-aD.....css-G.s.ss..sphsts......................................+hhs..uhtshs...hscGh+shchstssst.ss........YtapaC.thpVGcTYEVHWsHSu...hGACG....Ypp.ahsGVFsshs..................hsshsu.tus...tsltsulGVpuQVaslVNt.-E..p.hhY.shlcGhhl-ssts.......t-hshY.GSTTGpt.csN.-lCsua.usloWplDRpCHhloAuu.	0	11	15	16
+10396	PF10564	MAR_sialic_bdg		Sialic-acid binding micronemal adhesive repeat	Coggill P	anon	Chen Z	Repeat	This domain is a novel carbohydrate-binding domain found on micronemal proteins. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Toxoplasma gondii can infect and replicate within all nucleated cells [1]. This domain interacts with sialylated oligosaccharides; the protein in Toxoplasma gondii is a monomer but several MAR domains are carried on the protein. Each MAR domain contains one central sialic acid-binding pocket [2].	25.00	25.00	26.00	25.20	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-10.82	0.72	-4.23	17	151	2009-01-15 18:05:59	2008-04-16 17:48:43	4	12	14	13	55	153	0	94.00	27	32.00	CHANGED	LDpaC.sphuppsspsshp.hh........hhhAR.t.ttptttsh.WRCYspsphphstst.....ClDsCGshhs..C.uslpt.ssphhs+s....th.plIsppt......................hC	.........................lDthC.tph.tthstphhp.shsss......shVARhsh.s.psup..pst..WRCYstppLshstps.t...ClDsCGshhs..C.Gs.....lstsssp....ahTtp....pl.phIppt........................................	0	34	36	54
+10397	PF10565	NMDAR2_C		N-methyl D-aspartate receptor 2B3 C-terminus	Coggill P	anon	Pfam-B_53396 (release 22.0)	Domain	This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family Pfam:PF00060 further upstream as well as the ANF_receptor family Pfam:PF01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites [1].	25.00	25.00	32.80	31.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	681	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.28	0.70	-5.85	11	229	2009-01-15 18:05:59	2008-04-16 17:49:41	4	14	86	4	78	194	0	403.00	39	42.23	CHANGED	HLFYWpLRaCFhGVCSG+PGLlFSISRGIYSCIHGVpIE-K...thsSPoh....shssopSNhL+LLRoAKsMssloslNG....SP+sAh-Fh+p..cSulhDhupc+tshstsc.....s.sa.sc-shFuD.hS-lcpphuNlphccsNsYtcp.hpHthshst...........pPpSlGuuuSh-Gshs..................sopPRulh....KKslDhlttpsssssss.ptthssh.G+.sashKS.........sRYh.......st-..sh+SDlSDhSo+ssoYts.Eus..t+++pph+DoLKKRsuouK..R-hsElEL.......................shh+s.......spuus..cphYhh.pDKEslpsFalDQh+s+EGss..h-clDhs-hauscussh+pssss.........hthsoShlphc-h.....p....tpthspthshuspsps......sstussthuss..aCRSChS..............................phsuauuhs..tpsspusshRC-uCp.+sGNLYDISEDp.Lpct.........................tpsttupsshstthsQssstphp+pptttpLpRQHSYDsh.l-ht+Ets........................h.ssRSVSLK-K-Rah-Gsshh....................................h......utchhss+ssthhuucsttt.p.................sst..............hphSKSLYPD+sopNPFlsTasD.......D...QpLlHGupua.hhKpphs.............httpsps.tposhussSassssu..........Rhsp-lslu.....ppshshsssp...h.......ssPRshNuu..oNs+VYcKlsSIESDV	...................HLhYWphRash...po.sp.sh..lh..uhSRGIYSChpGVt...tp.....tsPsh....shs.spuNhL+hLpsAKshssh..sshps....S.ppshchh..................................................................................................................................................................................................................DhS-hSs+sssahp.-s......+p.p.+ssh.KRs.su+..+-.s.................................................tt.p..pp.a...t-pt...sh.....p..Es.sh..Epl-hs-.ap-ts-sh......++ssss.........h..sps..p.ccs.............hhtpthshtthsts.......s-hppp.tts..aCRSC.S..............................ph.sYus............p.shpssh+C-uCh.+hGNLYDIsEDp.Lp-h................................tts.t..tthsps.s.phtp.tp...p.lpRQHS..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	13	31
+10398	PF10566	Glyco_hydro_97		Glycoside hydrolase 97  	Coggill P	anon	Naumoff D	Domain	This domain is the catalytic region of the bacterial glycosyl-hydrolase family 97. This central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, form two additional non-catalytic domains [1].  In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands [2,3].	28.00	28.00	28.10	28.10	27.90	27.80	hmmbuild  --amino -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.74	0.70	-5.30	173	795	2012-10-03 05:44:19	2008-04-16 17:52:05	4	17	278	12	178	849	187	272.00	35	40.12	CHANGED	D.s.SWIK.PGKhsas.WWshtss............................tu...s...sscshKpYIDFAAchGhcalLl.........DtGWt.................sh..ps.sc....h-lpcLspYA+pKGltlhLWhppps...............hcpp.h.-cthphhpchGlpGlKsDFhsp...................-sQhhlpaYpcllcpAAca+lhVshHG.sh+PsGhpRTYPNhlspEuV+GtE..pths.......sst.spHsshLPFTRhluGPMDYTPGhhp.tht..................pspspsT...hu+QLAhaVlh.SPlQMh..uDtPpsY.....pp.......shpFlcslP	..................................DsSWIKPG.Khshs.WWphhss.......................t.s.ptuh...sspshKcYIDFA.Ap.....pGh-hlLl....stGWp....................t..hshhp.shs-...........hDlppLscYA+pKG..lhLhhpac..s..................................h-pp...h.-cthphhpchGlpulKss..ahss..........................ssQhhssaYhcllccAAca+lhVshHt.sh+P.oGlpRTYPNhlspEus+GtEh....ptas........sspspHsshLPFTRhluGPMDYTPGhhppthp................spsts.poT.hu+QLAhaVlh.SPlQMh..ADhPpsYtct.........sshpFlcsVP....................................................................................	0	71	152	170
+10399	PF10567	Nab6_mRNP_bdg		RNA-recognition motif	Griffiths-Jones S, Coggill P	anon	Pfam-B_57293 (release 21.0)	Domain	This conserved domain is found in fungal proteins and appears to be involved in RNA-processing. It binds to poly-adenylated RNA, interacts genetically with mRNA 3'-end processing factors, copurifies with the nuclear cap-binding protein Cbp20p, and is found in complexes containing other translation factors, such as EIF4G as in Swiss:P39935 and Swiss:P39936.	25.00	25.00	31.10	31.10	24.60	19.60	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.09	0.70	-5.44	5	25	2009-01-15 18:05:59	2008-04-16 17:54:03	4	4	24	0	15	24	0	317.80	46	30.36	CHANGED	INYKVLPKGcDsY+TRSLLFENV-..+-lDLHsFl+pFVKauPlESlYLIcsss...............csscsh-sDscN.............................pSILLSFLTKssCLDFYNNlLQRLSEFKTpL+SscLolSFVslpY.spp............sDEEush...p.hl..suLchNIlo+GATRSIsVEFpssVp..cpDhlpcKLPFLcsScNKRYILEuVDlINA--ssssFPpNYsILTFLNISMAlEVhDaL+t...p+shuIS+ChFVolss.h..................p+.Ss.Ssssssssp.psscosSVSshSt...................lSLossooslS..LscElDs....ht.lcL-tpsLplshS-Y.pPhIEpHscHL	........IsYKlLPp....GDDsYRTRSLLhENV-..cSIDLHShlcsFVK.sslESsYLIcus................psscsp-s-scs.............................hSILlSFLTKusCLsFYNNlLQR...LSEFKThLKS-uLsLpFVsLsYcscshsp..tt.......................t.p.NsEEsDl....s.hl.suSL+aNIsN+sATRSIhIEFc.osVc......KsD.LhcKKL.pFL.cpucNKRYILESIDLVNs-ss.sspFPcNYAlLTFLNISMAlEVLDYLKph..o+sLGISKChaVSlsshs.p..............ss++hSs.SsssusNscossssssspSshSs...........................S.hSLoSh.uSsVS..Ls-ElDhhs.pKLpulcLcsphLplshp-YpsPpIEpHosHL........	0	1	6	13
+10400	PF10568	Tom37		Outer mitochondrial membrane transport complex protein	Wood V, Coggill P	anon	Pfam-B_30563 (release 22.0)	Family	The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane [1]. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex [2].	21.50	21.50	21.50	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.44	0.72	-3.71	17	336	2012-10-03 14:45:55	2008-04-16 18:03:22	4	12	211	0	210	319	1	67.70	30	20.00	CHANGED	LHlWGhshslssIsspClAshahhphshspp..........hplVtSsNsslSsoscLPsLhs..ssphls....GatsIlpaLp	..........lahWus..s..au.LPSlcspsLAlhsYh+hssss...........hclhtpsN.s.h.hSPoGcLPhLps.....ss....ph..lo......thtpIlpaL.........................	0	40	81	150
+10401	PF10569	Thiol-ester_cl		Alpha-macro-globulin thiol-ester bond-forming region	Finn R, Coggill P	anon	PROSITE_PS00477	Domain	This short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.30	0.72	-4.72	83	1638	2009-09-13 17:40:59	2008-04-17 09:17:48	4	94	646	55	611	1531	44	29.30	44	2.09	CHANGED	sLspLlphPtGCGEQsMlphsPslhshpY.Lc	........tlppLlphPaGCGEQsMsthsPslhshpYLp.........	0	121	201	399
+10402	PF10570	Myelin-PO_C	Myelin-PO_N;	Myelin-PO cytoplasmic C-term p65 binding region	Finn R, Coggill P	anon	Pfam-B_1437 (release 22.0), PROSITE_PS00568	Domain	Myelin protein zero is the major myelin protein in the peripheral central nervous system and is essential for normal myelination. The family is a single-pass transmembrane molecule containing one Ig-like loop in the extracellular domain and this highly basic 69 residue C-terminal cytoplasmic domain which is the region that interacts with protein p65 [2].	25.00	25.00	29.80	29.30	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.35	0.72	-3.91	4	47	2009-01-15 18:05:59	2008-04-17 09:23:04	4	3	30	0	19	35	0	66.80	75	27.58	CHANGED	VRaCWLRRQuhLQRRLSAhE+GKLp+.AKDuSKR.uRQsPVLYAMLDpSRSsKuASEKKuKGh.GESRKDKK	............lRYCWLRRQAALQRRLSAMEKGKLHKsuKDuSKR.GRQTPVLYAMLDHSRSTKAASEKKuKGL.GESRKDKK.....................	0	1	2	4
+10403	PF10571	UPF0547		Uncharacterised protein family UPF0547	Coggill PC	anon	UPF0547	Domain	This domain contains a zinc-ribbon motif.	27.30	27.30	27.30	27.40	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.04	0.72	-7.45	0.72	-4.24	31	219	2012-10-03 10:42:43	2008-04-17 09:30:18	4	12	202	0	65	235	57	25.80	44	10.55	CHANGED	KpCPpCsppl........shusphC....shCGasFpt	...+pCPcCpppl........stuscpC....PpCGatFh.p...	0	21	30	44
+10404	PF10572	UPF0556		Uncharacterised protein family UPF0556	Coggill PC	anon	UPF0556	Family	This family of proteins has no known function.	25.00	25.00	31.70	30.30	21.10	16.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.09	0.71	-5.04	6	52	2009-01-15 18:05:59	2008-04-17 09:36:22	4	5	40	0	36	49	0	142.50	48	69.88	CHANGED	MAs.............hs.lh.hhhhh.sspuhpcspohEFDlRPGG.laoFopslt...cYpCsFTYAuQGGTNEpW.MSlGLS-DsphFSCSlWRPQGKSYLFFTQFKAEl+GAKIEYupAYSQsussupuDVPLKsEEapVo-osVopRsGpF+upLuKLsllu+spHDEL	................h...............hh.hhhhh........tusp.p........spohtFDl+PGG..lcoFopslt......capChFTYAuQ..GGT.NEpWpMolGhS-DpphFoCo..lWR...P...Q.G.KSYLaFTQFKAEl+G.AcIEYuhAYSpsuhttpuDVsLKsEEFpVoc..o..sVspRsGtF+ucLSKLslVA+t..t+sEL.........................	0	13	16	22
+10405	PF10573	UPF0561		Uncharacterised protein family UPF0561	Coggill PC	anon	UPF0561	Family	This family of proteins has no known function.	25.00	25.00	25.40	25.90	22.80	24.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.65	0.71	-4.28	5	61	2009-09-10 19:05:18	2008-04-17 09:38:23	4	4	45	0	43	47	0	107.90	50	52.62	CHANGED	MEs.u-upGcuVphKPGGRLDMSHGFVHHIRRNQIARDDYDKEVKQ.AKEKQRRRHTssPRRPRRPDLQVYpPRpRpGSp.ssss-sEEpsESoSo.poEsEssGspLFpLDYEADuG-ITSlIVaK	...........................thp.KPGGRLDMsHGFVHHIRRNQlARDDYDKcVK......Q..AKEchR+R+T...suPpR....P..R+P..D.....l.QVYhPR+R..cs.o...tt.s..ss-hEE...ssESoSS.to-.EspuppLFpL-YpADuGclTSlIVap........................................................	0	10	13	23
+10406	PF10574	UPF0552		Uncharacterised protein family UPF0552	Coggill P	anon	UPF0552	Family	This family of proteins has no known function.	22.20	22.20	22.40	23.70	19.90	22.00	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.40	0.70	-4.89	5	71	2009-01-15 18:05:59	2008-04-17 09:41:11	4	4	46	0	43	55	0	196.30	55	88.99	CHANGED	MSRIYpsTALpNKsVHsE+asGoW-PusaQuG-GVLLEGpLlDaSRHoIoDsKs+.......KERYYVLYIRPSRIHRRKFDsKGNEIEPNFSDTKKVNTGFLMSSY............................KVEAKG-SDRLot-QLssLV...NKspLl.......KIT-+H.sP+ETaAFWhPEuEM-KTELEsGpEVRLKT+GDGPFlFSLAKlDSGTVTKCNFAGDupAGASWTDNIMApKSspssu.ScspuQGDGA-DDEW	..................MShIYpsssLpscsVps.phsusWsPs..t..aQuGsGVLLEGpLh.DlSRHsI.Dspsp.......KpRaaVLYlcPuplH+R+FDs+GpEIEPNFSsT+KVNTGaLMSSY............................KVEAKG-oDRLo.-tLpsLV....sKs-.LL.......ulTpph..oPspolAFWhPEuEM-thELElGstVRLKT+GDGPFl-SLAKL-uGTVT.K.CNFA.....G...DsKTGASWTDNIMApKsocsss..sE...h.+p.QGDGA-D-EW.......	0	18	21	26
+10408	PF10576	EndIII_4Fe-2S		Iron-sulfur binding domain of endonuclease III	Finn R, Coggill P	anon	PROSITE_PS00764	Domain	Escherichia coli endonuclease III (EC 4.2.99.18) [1] is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidised pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand [2]. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease [4].	20.50	19.60	20.50	19.60	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.58	0.73	-6.71	0.73	-3.58	505	3890	2009-01-15 18:05:59	2008-04-17 09:52:34	4	11	2745	20	789	2381	391	17.00	50	6.34	CHANGED	Cps+.pPpC....stCPlp..sh.C	CpAR.KP+C....shCslp..ch.C.....	0	236	509	651
+10409	PF10577	UPF0560		Uncharacterised protein family UPF0560	Coggill P	anon	UPF0560	Family	This family of proteins has no known function.	19.40	19.40	19.40	19.50	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	807	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.66	0.70	-13.35	0.70	-6.28	7	258	2009-01-15 18:05:59	2008-04-17 09:54:33	4	17	49	0	134	241	0	425.80	28	87.35	CHANGED	lplKVQV.DsushpPLAsAsVElFuNpoul.ASGsTsuDGsshlthsY+LGo.llVoAoKpuYVsNSlPW+spRLPlauSVSLhLLPERsATLhlYEDlVpIluG..GARsQPhVpFQR+AlpLP.ssoYssLoAhLTsAuo..chcuFPahhGh-.uNuo.Gssshh-LsPlAAlSVHLhsusGspl.lsGPIpVSlPLPscss.LptsspVPAWRFD.phGsWl+sGhGhl+c-GsQLhWTaluPQLGYWlAAhsPspsG.lhsp....DIsoYHTlFLLuILGuhAlllLlLLClLLYYCRR+CLKPpppHRKLpLs.sL-..K+DQATShS+lNLl.....................................osts.ts..ss.L+...sopcDhspp..tphlpHpccspoth.....................tph-.a.hKuppsut.ppt.t.h.p--.ppuhsoh.sp....cp..tutusttphussss.sh.........t..tpths-u+ss-hhhopSlDpLpRPo..sh.opPGQlIhCuSlDplp-us.YRpshPTLVIPAHYh+LPuEtshsupshh.pspppp-htshpst.tpsa.........Q..stt.ptQthusppupsupuppW.u..ssshutSVoIPsshN-ushAQh.NuElQhLTEKpLhELGs...hPHPRAWFVSLDGRSNApVRHSYIDLQpuspstS......................sDASLDSGVDhNE.+suR+hc...............hpE+pt.pt.tssss....huhopLlYhEDh-.SuSEstsshs.SPEDsuLpslL-tuspsphsphsphtcpps+possSshps.sp.ppc.stpsptc.s-pst--tspsKKSPWQKREERPLhsFN	.............................................................................................................................................................................................................................................................s........h.......................h...h....s..h.hphsh.......................ss.h.ha.ap.t...............G..W.pts.s.l............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	18	26	57
+10410	PF10578	SVS_QK		Seminal vesicle protein repeat	Finn R, Coggill P	anon	PROSITE_PS00515	Repeat	\N	25.00	2.00	26.50	2.10	18.20	1.70	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.92	0.74	-5.80	0.74	-3.09	13	217	2009-01-15 18:05:59	2008-04-17 10:01:42	4	4	4	0	105	234	0	12.20	53	57.33	CHANGED	uQlKSFGQhKSp	....uQ.Ko....FuQpKo..	0	92	92	92
+10411	PF10579	Rapsyn_N		Rapsyn N-terminal myristoylation and linker region	Finn R, Coggill P	anon	PROSITE_PS00405	Family	Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane [1].	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.47	0.72	-4.18	4	91	2012-10-11 20:01:02	2008-04-17 10:43:49	4	29	73	0	53	118	3	78.90	50	17.87	CHANGED	MGQDQTKQQIEKGL+LYQuNpTpKALclWtpVLc+To-.sG+FRlLGCLITAHSEMGKY+-MLcFultQlssAREh-DP-	..........MGQcQs.KQpIE+.GLp.LY.puN..ppccALpsWp+sL...c...K...os.c.h...t.s.RF...p...lLGtL.hpAHsEhG+Y+-MLcFAlhQl-hAcELEDss.................	1	12	15	35
+10412	PF10580	Neuromodulin_N		Gap junction protein N-terminal region	Finn R, Coggill P	anon	PROSITE_PS00412	Domain	\N	18.50	18.50	22.20	22.20	15.90	15.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.51	0.72	-4.30	3	72	2009-01-15 18:05:59	2008-04-17 10:48:03	4	3	46	0	26	57	0	28.50	80	13.39	CHANGED	MLCCIRRTKPVEKNEEADQKIEQDG..IKPEDKA	.......LCChRRTK.pVEKN--.DQKIEQDG..IKPEDKA..	1	1	3	9
+10413	PF10581	Synapsin_N		Synapsin N-terminal	Finn R, Coggill P	anon	PROSITE_PS00415	Domain	This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin [3].	25.00	25.00	25.50	25.50	22.50	21.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.51	0.72	-4.13	5	136	2009-01-15 18:05:59	2008-04-17 11:41:42	4	5	42	0	56	160	0	31.30	77	6.20	CHANGED	MNYLRRRLSDSuFluNLPNGYMsDLQRP-PPu	.......MNaLRRRLSDSoFhANLPNGYMoDLQRP-ss.......	0	5	11	28
+10414	PF10582	Connexin_CCC		Gap junction channel protein cysteine-rich domain	Finn R, Coggill P	anon	Pfam-B_1437 (release 22.0), PROSITE_PS00408	Domain	\N	22.50	22.50	23.20	24.60	22.10	22.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.22	0.72	-4.16	76	1238	2009-01-15 18:05:59	2008-04-17 11:42:18	4	11	126	6	649	1009	0	66.10	49	21.43	CHANGED	hEluFlhsQYhLY.GFplsslahCs.ptPC...Pps.VDCFlSRPTEKTlFllFMhslos...lsllLNlhElhaL	..........................................hEluFlhsQYhLY..GF.p..lssla.pCs......p.............PC.............Pp.s..VDCFlSRPTEKTlFllFMhslus...lsllLNlhElhaL............	0	56	121	321
+10415	PF10583	Involucrin_N		Involucrin of squamous epithelia N-terminus	Finn R, Coggill P	anon	Pfam-B_7423 (release 22.0), PROSITE_PS00795	Domain	This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane [1].\	  Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis [2]. The downstream part of the protein is represented by the family Involucrin, Pfam:PF00904.	21.50	21.50	77.20	77.20	18.70	18.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.66	0.72	-3.67	9	42	2009-09-11 05:37:53	2008-04-17 11:45:25	4	19	29	0	11	37	0	68.00	69	15.11	CHANGED	MSQQHTLPVTLPPALSQE.LKsVSPPssTQQEQhKQPTPLPsPCQKV.SELPscVP.cHtEKHso.VKG	MSQQHTLPVTLsPALSQE.LKTVsPPssTQQEQhKQPTPLPsPCQKVssELPVEVPsKpEEKHhTsVKG..	0	1	1	1
+10416	PF10584	Proteasome_A_N		Proteasome subunit A N-terminal signature	Finn R, Coggill P	anon	PROSITE_PS00388	Domain	This domain is conserved in the A subunits of the proteasome complex proteins.	23.00	23.00	23.10	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.30	0.72	-6.55	0.72	-4.61	74	2896	2009-01-15 18:05:59	2008-04-17 11:46:05	4	19	554	763	1805	2718	83	22.80	63	9.05	CHANGED	YDpshosFSP-GRLaQVEYAhcA	.......YDpslTsFSP-GRLaQV.....EYAhcA...	0	629	1011	1482
+10417	PF10585	UBA_e1_thiolCys		Ubiquitin-activating enzyme active site 	Finn R, Coggill P	anon	PROSITE_PS00865	Domain	Ubiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin-conjugating enzymes (E2) [1]. This domain carries the last of five conserved cysteines that is part of the active site of the enzyme, responsible for ubiquitin thiolester complex formation, the active site being represented by the sequence motif PICTLKNFP [2].	19.90	19.90	19.90	20.20	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.45	0.72	-4.57	65	1276	2009-09-11 07:00:39	2008-04-17 11:47:32	4	44	343	39	841	1263	19	45.50	39	6.15	CHANGED	thTEsYssstcsspc..s...hPlCTl+shPpphpHCIpWA+.thFpphFs	............................hTpsYp..s..s.-..sspc...p......hPhCTl+shPpp..-HCI..pWA+..hFpphF............	0	310	475	688
+10419	PF10587	EF-1_beta_acid		Eukaryotic elongation factor 1 beta central acidic region	Finn R, Coggill P	anon	Pfam-B_9497 (release 22.0), PROSITE_PS00824	Domain	\N	25.70	25.70	25.80	25.90	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.64	0.72	-7.26	0.72	-3.79	37	495	2009-01-15 18:05:59	2008-04-17 12:56:35	4	11	254	0	245	487	0	27.50	62	9.97	CHANGED	LFGSD-E.EDcEAc+l+p.cRLAtYstKK	..LFG.S.D.-..E.-..ED.tEAt+l+E.ERLtpYspKK..	0	77	120	191
+10420	PF10588	NADH-G_4Fe-4S_3		NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	Finn R, Coggill P	anon	Pfam-B_202 (release 22.0), PROSITE_PS00642	Domain	\N	20.10	20.10	20.10	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.03	0.72	-4.72	191	4123	2009-01-15 18:05:59	2008-04-17 12:59:17	4	128	3222	15	1243	3421	1974	41.00	43	5.37	CHANGED	R+sllElLLssH....sh-CssC-.psGpCcLQchuhchGlpct+a	.......RcslhEhLLtNH....PL.DCslC-.puGcCcLQ.-huhthGhsppRa.........	1	463	862	1067
+10421	PF10589	NADH_4Fe-4S		NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	Finn R, Coggill P	anon	Pfam-B_339 (release 22.0), PROSITE_PS00645	Domain	\N	20.70	20.70	20.80	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.35	0.72	-4.81	299	3722	2009-01-15 18:05:59	2008-04-17 13:02:48	4	63	2661	15	1286	2965	2211	45.80	42	9.34	CHANGED	Vc.hspphhc.Fh...tcESCGpCTPCRtGot.hhhcllc+.l.tp...G..cu....p....................tpDl	............Vphspph.c..Fa.....t+ESCGpCTPCR-Gos.ahhcllc+.l..pp..Gcup.tDl...........................	0	477	891	1106
+10422	PF10590	PNPOx_C		Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region	Finn R, Coggill P	anon	Pfam-B_685 (release 22.0), PROSITE_PS01064	Domain	Pyridoxine 5'-phosphate oxidase (PNPOx) catalyses the terminal step in the biosynthesis of pyridoxal 5'-phosphate (PLP), a cofactor used by many enzymes involved in amino acid metabolism. The enzyme oxidises either the 4'-hydroxyl group of pyridoxine 5'-phosphate (PNP) or the 4'-primary amine of pyridoxamine 5'-phosphate (PMP) to an aldehyde. PNPOx is a homodimeric enzyme with one flavin mononucleotide (FMN) molecule non-covalently bound to each subunit. This domain represents one of the two dimerisation regions of the protein, located at the edge of the dimer interface, at the C-terminus, being the last three beta strands, S6, S7, and S8 along with the last three residues to the end. In Swiss:P21159, S6 runs from residues 178-192, S7 from 200-206 and S8 from 211-215. the extended loop, of residues 167-177 may well be involved in the pocket formed between the two dimers that positions the FMN molecule [2].	20.30	20.30	22.10	21.20	19.50	18.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.45	0.72	-4.46	243	2399	2009-01-15 18:05:59	2008-04-17 13:57:12	4	8	2210	18	735	1792	1629	42.50	54	19.13	CHANGED	WGGaRlhPpplEFWQGpssRLHDRhhY.............p.+..............................................p.ss.s.........WphpRLtP	.....WGGaRltPcplEFW.......QGpt.pRLHDRhhYpR...........................................................p..ss.s.......Wpl.-RLuP................................	1	211	437	608
+10423	PF10591	SPARC_Ca_bdg		Secreted protein acidic and rich in cysteine Ca binding region	Finn R, Coggill P	anon	Pfam-B_3882 (release 22.0), PROSITE_PS00613	Domain	The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2 [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.69	0.71	-4.05	28	665	2012-10-02 16:17:27	2008-04-17 14:18:31	4	31	135	6	337	1603	18	112.60	31	30.93	CHANGED	hssCs-p-LscFspRhRDWlpslhtphhccpptp...........................t..ph.pcsppp.hphhppsltWpFscLDts.tDphLs+pELtsl+usL...hshEpChpsFhpsCDsspDphIohpEWspC	...................................................................................................................................h..sCsst-htphs.RhtDWhpslh.phhpptp.p...............................................................................hp..h.....tp.....pp..h..shppp.sltW.h.F...s.pLDps.tDt...hLs+........pE.L....t....s.....l...c.t...l................sp...E.....+.C......h.............c..........t.............Fh.cpCD.s....s..pDptIohpEWstC..........................	0	74	101	207
+10424	PF10592	AIPR		AIPR protein	Iyer LM, Bateman A	anon	Iyer LM	Family	This family of proteins was identified in [1] as an abortive infection phage resistance protein often found in restriction modification system operons.	25.00	25.00	25.90	25.10	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.03	0.70	-5.10	65	420	2009-01-15 18:05:59	2008-04-17 14:47:42	4	2	382	0	123	388	93	298.40	19	53.89	CHANGED	h-pNVRsaLtsp.........s....VNpuIccTLp...ppPppFhhaNNGITllusclph..sssptt.......hplcshQ.........IVNGuQTosolaps.........tp.ptslsp.......lhV.l+lhhs......ps-....slhscIochsNoQNpVptpDhtupcshppclEphhpshh............haYERtcGpatstpstt....................p.hhspsthtphhssatpcPphsststpphapph.............t.hpphhp..tphst....hatphlshh.llhcthcphlpptt.....................tshstYsl...thhsthhttt.........................................shttlhppp.........plspphhptlhth.spphpchhppsstshtsh	..................................hppNlRsaLsts...........s....VNcsIpcTlp.................ppsptFahaNNGITlls.s..clph..pppst..........hpl.cshp............IlNGuQTssslhps..........................ttttplpp.......shV.l+llth.................psc....phh.spIocssNoQNpVpspDh.t.utcshppplcc.hhppht..............hhYcctcspht.spptph....................thhhsh.sthtp.hh..s..s.h..p.......p.........p.........Pp.h.....s.t.p..ttpphhpph.............t.hpphhs............sphst......hhhphlthh..hlhp....thpphhtptt...........t............................tphhhath......hh..hhttp................................................p..t..tt..............th.tth..p.h......................hh..........................................................................................................................................................	0	40	94	115
+10425	PF10593	Z1		Z1 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This uncharacterised domain was identified by Iyer and colleagues [1]. It is found associated with a helicase domain of superfamily type II.	25.00	25.00	25.10	48.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.68	0.70	-5.15	35	212	2009-01-15 18:05:59	2008-04-17 14:51:00	4	3	199	0	78	223	142	234.80	28	28.00	CHANGED	pSLccAlpsFllusAlRplR.....Gt.sscHs................SMLlHsS+hssspcpltshl.pph..lpplcpslpttsstt.........hscL+placpch..................ps.sh.sas-ltstLhpsl....s................s..lclhllN.ussp..-s....LDYssspt.h......ssIslGGspLuRGLTlEGLssSYFhRso+...hhDTLhQMGRWFGYRtsYtDLCRlah..........ot-lhphFpplspssE-LRppl.cphttss.....hTPppaulpVpsps...sLtlT	..........sLccAlhsFllssAl+thR..........Gp...tpc+p.................SMLlHsSphpsspppltphl.pph....hpplppslpttpsts...........hschcplappcht.......................tt.ph.sa--l..h..p.tLhpsl...p.....................s..lplhhlN.ssss..ct.......l-appppt...........tsIslGGspLuRGLTlEGLssoYahRsop...thDTLhQMGRWFGYRts.YtDL..sRlah..........st-lhphFppls.pspp-lRppl.cphtt.ts......hsPhpashplpsp.....h.............................	0	24	58	70
+10427	PF10595	UPF0564		Uncharacterised protein family UPF0564	Coggill PC	anon	UPF0564	Family	This family of proteins has no known function. However, one of the members, Swiss:Q22CP8, is annotated as an EF-hand family protein.	21.10	21.10	21.10	21.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.63	0.70	-5.54	15	182	2009-01-15 18:05:59	2008-04-18 09:08:17	4	5	94	0	110	180	3	304.80	25	51.40	CHANGED	.cITVPpPFphshREpc+pp.t.hpppclcp.hpchpcc..-csEhp++F+ApPVPppVhlP.LYcclhccpEcRRcpl+ccS+thhLps.pKPFpFhtR-cpKcphh.pp.............pcccsppF+A+P...lPcphhtshlpph.....................pEcEhhRppRsphRup-hlps.SphPschtpptpppp.t...............+ptpspppttcpshcsh+s+slPDFccLacsFpcphscp.............KppppsTlscPFshppS.p+sss+cphspts.pht.............................pcsl+tspc................................P................................hpt.p.h.phhcpph.c+.t+pp...cphp.RcKptpchuspsppphpstssspphpcppccphhph+cc.cKpcpcEYpppl	...........................plTlPpPFpMplREtp++t....htp...s..phE..pp.hpcp...t-..c......t....cpp..+pFRApPVPspValP.LYpclhcppEtRRp.hppcp+thLhup..KPFpFht.........+-cpccth...ttpp..th.............tppp.tpt.h+A.+.........l.P+shhtssht-+....................................hpEpEhhRpl+.hphRAt-hLpp..ushP.p.tt..tp.....................................pptc.hs....t..........t..p.h.phps+hpstsPDa-tLhc.papc..phtcp...............+p....+.sTh.scPFp....Lpsu....htt..sp.+tp.h.t..s.httc................................................ppp.p.sph................................................P.....................................s...s..ppttt.pth+pp....pch.t.pt..p.p..h.p.php.p.....h.cp....ht.p.tt.....s.t.p..t................................................................................................................................................................................	0	37	50	76
+10428	PF10596	U6-snRNA_bdg		U6-snRNA interacting domain of PrP8	Coggill P	anon	Chen X	Domain	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [1].	29.80	29.80	30.70	31.80	28.70	29.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.01	0.71	-4.87	11	381	2012-10-03 10:25:13	2008-04-18 15:27:45	4	48	305	0	252	401	3	149.80	76	7.47	CHANGED	FpcYpls+tssahWTpp+HDGKLaN..LpsY+sDhIpALGGlEsILEHoLFKuTtassWEGLFW-K.............sSGFEpoh.Kh++LTNAQRoGLsQIPNRRFTLWWSPTINR..........usVYlGFQlQlDLTGlFMpGKlPTLKISL...IQlFRuHLWQKIHESlVhDLt...QhhDsEh	..............................FKpYQlhKpNPFWWTpQRHDGKLWN...LNsYRTDhIQALGGVEuILEHTLFK...........GThFPoWEGLFWEK.............ASGFEESM.KaKKLTNAQRSGLNQIPNRRFTLWWS.PTINR..........ANVYVGFQVQLDLTGIFMHGKIP..TLK..ISL...IQIFRAHLWQKIHESlVMDLC...QVFDQEL...................	0	89	139	206
+10429	PF10597	U5_2-snRNA_bdg		U5-snRNA binding site 2 of PrP8	Coggill P	anon	Chen X	Domain	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].	21.20	21.20	21.20	21.30	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.65	0.71	-4.57	20	335	2009-09-11 09:17:08	2008-04-18 15:56:36	4	42	290	0	237	321	1	133.60	72	5.89	CHANGED	sppEusWsLhspsTKEpTApAa.LpVSccuIspFcNRlRpILMoSGSoTFoKIAsKWNTsLIuLhTYaREAllsTppLLDlLVKsEsKlQsRVKhGLNSKMPoRFPPsVFYoPKELGGLGMLShGHl.LIPpSDL+aS	...................s.+DGVWsLpNcsTKERTApAF.L+Vs-Eslp+FcNRlRQILMuSGSTTFTKIsNKWNTALIuLhTYaREAsVsTp-LLDlLVKCEsKIQTRlKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHl.LIPpSDLRWS...........	0	88	134	197
+10430	PF10598	RRM_4		RNA recognition motif of the spliceosomal PrP8	Coggill P	anon	Chen X	Domain	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [1]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [2].	23.50	23.50	24.70	24.20	21.80	23.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-10.18	0.72	-4.12	25	346	2009-01-15 18:05:59	2008-04-18 16:21:12	4	41	284	0	246	321	7	92.10	69	4.12	CHANGED	EKlDhTLLNRLLRLIlDpNlADYITuKNNVslsaKDMsHlNpYGlIRGLQFoSFlaQYYGLllDLLlLGlpRAsElAG..PsstPNsFhpFpstps	............EKIDLTLLNRLLRLIlDHNIADYhTAKNNVslsYK......DMNHTNSYGlIRGLQFuSFlhQYYGLVlDLLlLGLpRASEhAG..PPQhPN-FLpFpDh.s...........................	0	97	143	207
+10431	PF10599	Nup_retrotrp_bd		Retro-transposon transporting motif  	Wood V, Coggill P	anon	Wood V	Domain	This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organisms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localisation signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity [1].	25.00	25.00	27.50	27.50	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.48	0.72	-3.39	6	66	2009-01-15 18:05:59	2008-04-18 16:42:08	4	6	41	1	25	66	0	97.30	60	7.65	CHANGED	ppuTPsPuSlFsh.GsoNsNhs.........psssPS....osFuFus..shs.......................tstsssSuhssss....hSso..........Ps.....hshGssst.........shssRKIApMR.pR+R	....u.soTPNuSSVFQF.GSS.TTNFNF........TNNNPS....GVFTFGAssSTP.......................AASAQPSGSGuFs....FsQS..........PAu....FTVGSNGKNhFSSSG.TSVSGRKIKTAVRRRK.........	0	3	4	10
+10432	PF10600	PDZ_assoc		PDZ-associated domain of NMDA receptors	Coggill P	anon	Pfam-B_10923 (release 22.0)	Domain	This domain is found in higher eukaryotes between the second and third PDZ domains, Pfam:PF00595, of glutamate receptor like proteins. Its exact function is not known.	21.20	21.20	22.00	22.30	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.44	0.72	-3.68	12	321	2009-09-11 14:48:04	2008-04-23 15:51:39	4	37	37	29	104	277	0	65.50	53	8.76	CHANGED	KPoohahs..DsYuPPDITsSYS.thDNclS.su.lG.......ch.psLsP.sSPsRYSPlPKshLG-DDloREPR	.....KPoohYhs..DsYuPPDITs.S.....aSt.....hDNHlSpsu.LGh.......c...shs.P..sSP..uRY.SPlsKphLG--D.hT.R.EPR................................	0	4	14	41
+10433	PF10601	zf-LITAF-like		LITAF-like zinc ribbon domain	Protasio A, Bateman A	anon	Clustering of trematode sequences	Family	Members of this family display a conserved zinc ribbon structure [1] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [3].	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.05	0.72	-4.11	46	755	2009-01-15 18:05:59	2008-04-24 10:49:46	4	16	214	0	542	755	1	70.80	27	40.68	CHANGED	hpssPs.hhCPpCpppshTplphcsGssTa.........hsshlLhhhh..hsC.shlPashcssKDshHhCPsCsshlGhach	...........h...tPsphhCPpCpppl.......hTpl.phpsGhho.a.................lhsh...h.....l.....slhsh...h.....s.....C....sh...lPhhhss.hp.-spHhC..PsCpthlupap................	0	237	298	446
+10434	PF10602	RPN7		26S proteasome subunit RPN7	Mistry J, Wood V	anon	Pfam-B_4112 (release 22.0)	Family	RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity [1].  The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.	29.40	29.40	29.40	29.50	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.75	0.71	-4.89	63	673	2012-10-11 20:01:02	2008-04-24 12:50:55	4	12	331	0	453	671	11	171.80	30	40.18	CHANGED	DpshhcphppcNppclpcL-pclcchc.cNhscp-l+puhhchu-aYtclGDhcpAlcsapc.sh-hssusup+lDhhhsllRlulahsDhshVpphlp+Acshh-p..uuD........................................W-p+NR..............................LKsYpGlhtlshRcacpAAphhL-ohsTFsu......sElhoapslshYuslsulhoh-Rs-L+pK	...........................................DpshhpphpcpsptclccL-pclc......shc..pNhhc.pplR............p..uh.chu-aahclG.Dh.............psA.................lcsap.............+..sh....-.h....s....s..uhsphl-hshpll+l....ulaht.Dhsh.lp.pt..lpKAc...shh-p..usD.................................................................................hc.p.+s+..............................LKsh..pGLhplu.h....R...sa+pAAph..........FL-s..h...ssass.................hELhshpslshYsslsulhoh-Rs-L+p................................................	0	160	250	371
+10436	PF10604	Polyketide_cyc2		Polyketide cyclase / dehydrase and lipid transport	Lakshminarayan L, Mistry J	anon	Manual	Family	This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-11.10	0.71	-4.01	179	5359	2012-10-02 19:24:03	2008-04-24 14:10:18	4	67	1547	79	1946	8699	1599	142.00	13	81.08	CHANGED	thplpps......h....pls.ussppVashlsD...h..sshs......p....W......ts..slh...ps..p......h.s...t...sss......................hh....tthp.hsu..........................lppplsp..h....c.s....tpthsach...............hsht...ph..tss.hplps...ss..s.......G.....sp..ls...ash......pht......................shh.............t.h........ht....thlpsh....hpt.sLppLppthc	...................................................hptsh.tl..s..AssppVa.s...h...l.sD.......h..p.ph.s.......p..........W............hs....tlp........ps.......c..........hh....p.......sss......................................th......t..php..hsu.....................ht..........................h.p..p..p......l..h...p......h.............c...s...........sp..t..l.s..aph............................hsht.....ph...t......sp..h..pl..ps........ts.......s................G..............op....lp...........hph........p.hp...............................s.h....................t..h.........ht......thhp...t...........hpt.s....lptLtt................................................................................................................................	0	564	1317	1714
+10437	PF10605	3HBOH		3HB-oligomer hydrolase (3HBOH) 	FIGFAMs, Mistry J	anon	FIG094011 (Release 2.0)	Family	D-(-)-3-hydroxybutyrate oligomer hydrolase (also known as 3HB-oligomer hydrolase) functions in the degradation of poly-3-hydroxybutyrate (PHB).  It catalyses the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers.	25.00	25.00	27.00	25.30	23.40	24.90	hmmbuild  -o /dev/null HMM SEED	690	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.16	0.70	-6.45	13	134	2009-12-10 17:34:17	2008-04-24 14:14:15	4	3	127	0	41	138	14	584.70	48	90.33	CHANGED	lsluACsGussssss.....................hNs+PuFl..GsVphpuYDGsoDDLLTAGLGKoGLuSATAPuhAsPssPTAAELRRLAIasNYRALVDsousGGYGoLaGP..NVDAsGssTs.G-GKIAGsEYlAYuDDGoGppNVTlhVQVPsoFsPspPCIVTATSSGSRGVYGAIuouGEWGLK+GCAVAYTDKGTGsGsHDLsTsTVsLIDGTRsstsuAGpsutFsAsLuAss.LAsFNuuhPpRhAaKHAHSQQNPEpDWG+hTLQAlEFAaasLN-paGstsssGts..hplpPusslVIASSVSNGGGAAlAAAEQDTcGLIDGVAVuEPplNlssssulsV+RGusP.lsusG+sLhDYsThANLLQsCAAlAsuhss.APhtsshsss......sltsNRCsoLsApGLloGuTTusQAssALstLct.sGapPESslLpAShashpsssuIAVTYANAYuRASVpDpLCsaSFAuTsAsss.....ssshusushAolFusGNGlPPTsGlsLVNssutG.sPh.shsSlS.usup.DhNl-GALCLRsLhoGsDus............u.tlppGlsplptoGNLpGKPAlIVpGRuDALlPVNHTSRPYlGLNptsEGusS+LSYlEVTNAQHFDAFlG....lPGYssRaVPLHhYhhQALDhMYupLpsGsPLPPSQVVRTlPRGGssu..sAPslosANVPPIssoPuAuDtIslssu....sVsVPD	.........................s..huuCtus.psst.....................hNthPu.al..GsVphssY.........DG.........soDDLLTAGLGpoGLuusosPuhAsPspPTAAELRRlAIauNYRALVDhossGGYGphaGP..NVD.h...s.GssTh.G-GhIsGsEYlAauDDGoGppNVollVQlPsoFssspPCIlTATSSGSRGlYGAIus.GEWGLK+GCAVAYsDKGsGsGsH-luossVsLlDGThsstssAGssuhFsAshosu.p.LAAFNuthPNRhAaKHAHSQpNPEpDWGp.TLQAlcFAaasLN..-pa.Gshs.......ss..st.p..hphpssshhsIAuSVSNGGGAulAAAEQDs....p...GhIsuVsVuEPplNl......ssshs.VppGGss..lsshG+PLhDYsThANLhpsCAAhusu..h..ss..uPh.huhh.shsh....tuhtspRCAsLt..AtGLloG..ussssQAs-.....ALtpLcs.hGa.s-SDhlpAshhs.ps.PulAsTYANAYsRupVpDNLCsaSFAsssssss.....ssssssushsshFusGNGlPP.TsGlpLl.Nsu.....tG........uls.phus.DhshsGAhCLRpLhTus...................thultsulstlthsuNLpGKPAIIVpGRuDALlPVNHuSRsYluhNptsEGtt.SpLsahEVsNuQHFDuFls...........lPGaDTRFVPlHhYt.pALshMasaL+s.GsPLPPSQVlRTlPRGGssG..uAPAlosANlPslstsPuA.stIssssu....slsVP...............................	0	4	16	29
+10438	PF10606	GluR_Homer-bdg		Homer-binding domain of metabotropic glutamate receptor 	Coggill P	anon	Pfam-B_17370 (release 22.0)	Domain	This is the proline-rich region of metabotropic glutamate receptor proteins that binds Homer-related synaptic proteins. The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich "Homer ligand" (PPXXFr). Activation of PI turnover triggers intracellular calcium release [1]. MGluR function is altered in the mouse model of human Fragile X syndrome mental retardation, a disorder caused by loss of function mutations in the Fragile X mental retardation gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners [2].	25.00	25.00	26.50	25.80	18.30	18.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.73	0.72	-4.07	5	118	2009-01-15 18:05:59	2008-04-24 14:35:50	4	4	37	1	60	89	0	50.30	66	5.05	CHANGED	ALTPPSPFRD.SVuSGSSsPu.SPVSESlLCsPSNspYsSlIL+DYoQSSSTL	....ALTPPSPFR.D.SVsSGSosPs.SPVSESsL..........C..........h.PssspYsolIlRDYsQSSSoL........	0	2	8	30
+10439	PF10607	CLTH	RanBPM_CRA;	CTLH/CRA C-terminal to LisH motif domain	Coggill P, Bateman A	anon	Pfam-B_3765 (release 22.0), UPF0559	Domain	RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.  This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined [5]. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif [6].	23.00	23.00	23.00	23.00	22.80	22.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.68	0.71	-4.50	132	1458	2009-01-15 18:05:59	2008-04-24 14:51:03	4	27	290	0	1000	1417	5	169.80	20	40.24	CHANGED	hhtphpcIhcsl..ptclppAlpWssc..............................ppspLhch......p...........................ssLc.FcLph.paIELl+................p......................................................................................................................................sp..................................hhcAlpau+c......pl.s...hsp...........................t....hhp-lpphhuLLsats....................................................................pshpp.......................Lhss.pp..............hpplsppFspsh..hphh..shs.......p........ps........................LthhlpsGh.ulpshh	...............................................................................................h.ptpcItctl.tps.p.lppAlph.s..pp..........................................p.s.p..Lhcp..........s.....................................................................................................ssL...FpLpp.p.a.lELl+...............s......................................................................................................................................................................................................................................................................................................................................................................sp...............................................hp..cAlpaupp...........pl..s......hsp...............................phhc-.l.p.c.s.huLL.sa.ssstp.......................................................................sshtp......llss..pp.................hpplssthspsh...h.phh...shs...........p...........ps........................Lthhlptsh.sh....h.............................................................................................................................................	0	321	541	796
+10440	PF10608	MAGUK_N_PEST		Polyubiquitination (PEST) N-terminal domain of MAGUK	Coggill P	anon	Pfam-B_18049 (release 22.0)	Domain	The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination [1]. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerisation of the whole protein [2].	21.60	21.60	23.00	21.80	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-10.03	0.72	-3.58	14	339	2009-01-15 18:05:59	2008-04-24 15:02:41	4	33	36	21	110	279	0	70.70	44	10.98	CHANGED	p+YRYQD--os.P.E......pSssplsscshssELlclu-K..sluph-Nl.......HGaVsHsHISPh..................................................pAsssPllVNT-oL-sssY...VNGT-s-aEaE	..............................................tYth.spps...P.p.........s.hstt......................................sh..p..hosh...................................................pAsss..PllVNTDoL-sssY.........VNGT-u-hEYE.................................................	0	5	15	41
+10441	PF10609	ParA		ParA/MinD ATPase like	Mistry J, Wood V	anon	Pfam-B_177 (release 21.0)	Family	This family contains ATPases involved in plasmid partitioning [1].  It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.68	0.72	-4.10	250	4990	2012-10-05 12:31:09	2008-04-24 17:05:32	4	43	4013	3	1687	4768	2898	81.20	48	23.71	CHANGED	LDYLllDhPPGTGDhp.LolsQpl..........s..............ls.......Gul.lVTTPQ-l..........AlhDscKulshh..c+hslPllGlVENM......ShahCPp.C.....ucppplFG..pG	..............................LDYLllDhPP..G..T.G..Dl.p.LolsQpl...........P..................................ls....Gu..llVTTPQcl.................AlhDA...cKuls.Mh..c..K...l......p.l..P.l.L.........GlV.E...N.M......S...h..a..hCss..C.....Gcc..ptlFGp...........................................	1	591	1076	1434
+10442	PF10610	Tafi-CsgC		Thin aggregative fimbriae synthesis protein	FIGFAMs, Mistry J, Coggill P	anon	FIG009025 (Release 2.0)	Family	Fimbriae are cell-surface protein polymers, of eg. E coli and Salmonella spp, that mediate interactions important for host and environmental persistence, development of biofilms, motility, colonisation and invasion of cells, and conjugation. Four general assembly pathways for different fimbriae have been proposed, one of which is extracellular nucleation-precipitation (ENP), that differs from the others in that fibre-growth occurs extracellularly. Thin aggregative fimbriae (Tafi) are the only fimbriae dependent on the ENP pathway. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. Tafi are known as curli because, in the absence of extracellular polysaccharides, their morphology appears curled; however, when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix. The gene agfC is found to be transcribed at low levels, localised to the periplasm in a mature form, and in combination with AgfE is important for AgfA extracellular assembly, which facilitates the synthesis of Tafi. The genes involved in Tafi production are organised into two adjacent divergently transcribed operons, agfBAC and agfDEFG, both of which are required for biosynthesis and assembly [1].	25.00	25.00	26.80	26.60	22.20	20.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.53	0.72	-4.21	2	412	2009-01-15 18:05:59	2008-04-24 18:01:26	4	1	407	3	12	89	0	103.40	84	92.46	CHANGED	LLLAALSSQITFNTTQQG-lYTIlPpVTLopsClCcVQIhulR-GpuGQSpTpQcpTLSLPANQPIsLT+LSLNISP-DpVKIlVTVSDGQSLHLSQQW.PSsEKS	...................LLLAALSSQITFNTTQQGDlYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISP-DRVKIVVTVSDGQSLHLSQQWPPSSEKS......	0	1	3	7
+10443	PF10611	DUF2469		Protein of unknown function (DUF2469)	FIGFAMs, Mistry J	anon	FIG004032 (Release 2.0)	Family	Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	25.00	25.00	29.00	137.90	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.36	0.72	-3.65	12	430	2009-09-11 15:00:03	2008-04-25 09:17:54	4	1	430	0	109	192	35	101.10	69	98.07	CHANGED	MSAEDLEpYEoEMELpLYREYRDVVGlFpYVVETERRFYLsNpV-lpsRoss.G-VYFEVoMsDAWVWDhYRPARFVKsVRVlTFKDVNlEELsKs.-l.-lPc	..MSAEDLEpYEs-MELsLYREY+DVVG.FoYVVETERRFYLANsV-lpsRs.s.s.G-VYFEVphuDAWVWDMYRPuRFVKpVRVlTFKDVNIEE.lsKs.Dl.clPp......	0	33	80	101
+10444	PF10612	Spore-coat_CotZ		Spore coat protein Z	FIGFAMs, Mistry J, Coggill P	anon	FIG014057 (Release 2.0)	Family	This family has members annotated as Spore coat protein Z, otherwise known as CotZ, It is a cysteine-rich spore coat family, and along with CotY is necessary for assembly of intact exosporium.	19.90	19.90	20.40	21.00	18.30	17.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.82	0.71	-11.46	0.71	-4.34	11	223	2009-01-15 18:05:59	2008-04-25 11:28:31	4	2	119	0	21	136	0	148.80	56	93.76	CHANGED	MSCsppcth.......tspNCVs-sVctIc-LQ-us..--..sCsTuCasshLu..sos...shuDThPFlLaTKpGsPFpA...Fu.ssuplsss...Ch.SsFFRVEslcD.sCAsLRVL..........pshststshLchs-ps..........lCps..............hcLcKTshCIpVDLsCFCAIQCLssphl	......................MSCNpNccH.......ss.sCVssVV+FIpELQ-Cu..TT....TCGSGCEl...PF...LG...AHNsA..SVANTRPFILYTK....sG.sPFEA.....FA..PSusL..suCc......SPIFRVESlDD.D..s.C.AVLRVL...................oVVLGDs...osVPPsDDP................ICTFLu.........VPNARLlSTsoCITVDLSCFCAIQCLRDVoI........	0	4	11	13
+10445	PF10613	Lig_chan-Glu_bd		Ligated ion channel L-glutamate- and glycine-binding site	Coggill P	anon	Pfam-B_203 (release 22.0)	Domain	This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.	20.30	20.30	20.30	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.10	0.72	-3.99	82	1132	2012-10-03 15:33:52	2008-04-25 14:02:08	4	36	106	435	539	1967	2	64.60	46	8.17	CHANGED	PasM.h+ps.......h...tuspp.aEGaClDLlcclAchl.sFsYcltlV.tDG..pYGshpp..sG.........pWsGhlGELlp	..................................PYVM.h+cs.......tp.h...pGN-R..aE...GYC...lDLlp........E..l......Ac..h......l......G.......F.......p...Yc.l.plV...sDG.............KYGup-s...ss...................pWN.GMVGELl...................	0	155	196	354
+10446	PF10614	CsgF	Tafi-CsgF;	Type VIII secretion system (T8SS), CsgF protein	FIGFAMs, Mistry J, Coggill P, Desvaux M	anon	FIG077109 (Release 2.0)	Family	The extracellular nucleation-precipitation (ENP) pathway or Type VIII secretion system (T8SS) in Gram-negative (diderm) bacteria is responsible for the secretion and assembly of prepilins for fimbiae biogenesis, the prototypical curli. Besides the T2SS that can be involved in the assembly of prototypical Type 4 pilus, the T4SS that can be involved in the biogenesis of the prototypical pilus T, the T3SS involved in the assembly of the injectisome and the T7SS involved in the formation of the prototypical Type 1 pilus, the T8SS differs in that fibre-growth occurs extracellularly. The curli, also called thin aggregative fimbriae (Tafi), are the only fimbriae dependent on the T8SS. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. In the absence of extracellular polysaccharides Tafi appear curled, although when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix [2]. CsgF is one of three putative curli assembly factors appearing to act as a nucleator protein. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery [1].	25.00	25.00	29.70	29.60	24.30	18.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.69	0.71	-4.19	6	534	2009-01-15 18:05:59	2008-04-25 14:25:13	4	2	527	0	56	165	266	127.60	69	95.73	CHANGED	h+hhGl..hAhLlhhtA..ussApAusLVYpPhNPsFGGsPhNuuaLhupANAQNphpcsstsss.............ps.Spu-hFApQLQoQLLSuLusQlspAIFG-ssQcuGshoFsupoloas+sssslslsIsDssTGpsTpIsVP..ss	......................hl...........l.hhhh....SP.LoWAGsMTFQFRNPNFGGNPNNGAFLLNSAQA.QNSYKDPSY.s-DFGI..........ETPSALDNFTQAIQSQILGGLLoNINTG..............K..P.....GR...........MVTNDaIVD.IA.N.R.D.GQ.LQLNVTDRKTGpTSTIpVSGLQs......................	0	12	22	37
+10447	PF10615	DUF2470		Protein of unknown function (DUF2470)	FIGFAMs, Mistry J, Coggill P	anon	FIG076093 (Release 2.0)	Family	This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	21.00	21.00	21.00	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.98	0.72	-3.76	50	682	2009-01-15 18:05:59	2008-04-25 15:11:28	4	12	625	9	274	592	273	81.30	25	33.83	CHANGED	tuDPlsst...susplspHMNsDHu-AlhtYAptauGl.....sss...ssA.......pMtul-spuhcLpl.............ss.tslclsF-ps.......Lsssp-s+psLVtMs	.................................h............tppllpHMNs-Htcsltths.c..p.a..ush...........tps...........pss..........................phhulDhpGlclth...........t...............sp.pslRl.Fsp.........ss.-.ps.l+psllth...................................	1	87	181	241
+10448	PF10616	DUF2471		Protein of unknown function (DUF2471) 	FIGFAMs, Mistry J, Coggill P	anon	FIG076041 (Release 2.0)	Family	The function of this family is unknown. Members all come from Burkholderia spp. Swiss:A2WH83 is annotated as Serine/threonine-protein kinase, but this could not be confirmed.	25.00	25.00	31.20	31.00	22.30	18.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.56	0.71	-3.93	7	81	2009-01-15 18:05:59	2008-04-28 11:07:54	4	1	56	0	27	68	4	122.40	49	95.15	CHANGED	spp.slsslpFcpAAc....DLc+IVtpIAtRYlspt........VslTWphLhsIEtEAhuDLGFtSRpDushlshF.R.ushphPtsD..-hlDasp.ossLPAVathshsthEpsu.cA.pp................Ahss	...................p-psLAALpFcsAA+....DLEpIVppIApRYIpQp........VPLTWRLLHAlEAEALADLGFASRHDshlhsLFpRPu-hcaPETD..DsVDFGp.SsALPAVFuFAVuAYEtAA.c.sttp...sst................	0	1	5	13
+10449	PF10617	DUF2474		Protein of unknown function (DUF2474)	FIGfam, Mistry J, Coggill P	anon	FIG073099 (Release 2.0)	Family	This family of short proteins has no known function.	24.80	24.80	24.90	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.92	0.72	-4.36	18	344	2009-01-15 18:05:59	2008-04-28 11:30:32	4	1	323	0	76	225	3	39.40	44	83.46	CHANGED	ppshW.pRLuWLllIWuuSVhALGlVAhlhRLhMsAAGLpo	......h...hW.+RlsWhlsIWsuSVLsLusVuhLhRllMsuAGhpo.....	0	6	24	51
+10450	PF10618	Tail_tube	DUF2473; 	Phage tail tube protein	FIGfams, Mistry J, Bateman A	anon	FIG030252 (Release 2.0)	Family	This bacterial family of proteins contains phage tail tube proteins related to the Mu phage protein Swiss:P79679 [1]. Bacteriophage Mu has an eicosahedral head and contractile tail. The tail is composed of an outer sheath and an inner tube.	21.60	21.60	21.90	22.00	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.01	0.71	-4.37	24	282	2009-01-15 18:05:59	2008-04-28 12:44:06	4	1	261	0	33	148	1	116.70	36	98.55	CHANGED	Mut..plsGsshl+lsGt.plpspsu.sphs.ushpREslhG..stlhGapEp.p.sshlcsslhsstshs..ltclsshsshTlohEhsNGpsYllssAahs-s..sspsc-GplslpacGppsph.	.............u..+luGTsal+lDGp.pLslsG.G.hchshsshtR-slhGh.sushsa.KEo.+.APalcsohpsstshs..lscIs.stsshTIs.sE.huN..GpsYlhosAWhtsps..shss--GTl-.lcFcGppush.........	0	6	14	25
+10452	PF10620	MdcG		Phosphoribosyl-dephospho-CoA transferase MdcG	FIGfams, Mistry J	anon	FIG003211 (Release 2.0)	Family	MdcG is a phosphoribosyl-dephospho-CoA transferase that is involved in the biosynthesis of the prosthetic group of malonate decarboxylase [1].  Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage. MdcG catalyses the following reaction: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + apo-[acyl-carrier-protein] = holo-[acyl-carrier-protein] + diphosphate.	26.10	26.10	26.40	45.10	22.10	25.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.39	0.70	-4.80	47	349	2012-10-02 22:47:23	2008-04-28 15:00:13	4	2	315	0	97	355	6	191.60	29	95.30	CHANGED	M.....................p.HDLlalpssu....hh.......ssss.shltshh.....tsuhPlVVRRs.s....sssGtlslGlth.....tspcp..RhuhhlssssltcshsP.sLsph.......hst..tshsh.htslps.L.s.s.ssh....shshtlhGSsuap......................hhTGlshlpssSDLDLllps.sssh...phpplhphLt...ppts.hRlDsplphPsG.uVuh+Ehtssss.....pVLlKstcGspLhsps..a	......................................t.HcLlhhts.s....hh...................s.st.taltthh.....ttuhPllVRRs.s....sssstlslGlps.....ttppp..RhAh.hshssltphhsP.sLsph.........tt...tsh.sh..h.slpt..ltshh.pth....shshGlhGShuap......................hsTGlshlpss....SDLDLL.lps.spsh........phtthlphl...tt.h.tphs.hRlDspl.hs.p.G.uhuh+Eahtsst.............plLlKospGspLhtss..................	0	13	40	66
+10453	PF10621	FpoO	zf-Fe2-S2-FpoO; 	F420H2 dehydrogenase subunit FpoO 	FIGfam, Mistry J, Coggill P	anon	FIG062058 (Release 2.0)	Family	This is the FpoO subunit of F420H2 dehydrogenase, an enzyme which oxidises reduced coenzyme F420.  Reduced coenzyme F420 is a universal electron carrier in methanogens.	25.00	25.00	45.10	45.00	20.20	22.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.66	0.71	-4.03	3	11	2009-09-11 06:40:42	2008-04-28 16:08:27	4	1	10	0	9	10	0	103.40	43	94.51	CHANGED	MTDCDLCG+AIPTVIPVRVFRPRLKFAYPEGVWKGLCEuCLDSAQKTYLElNKcpsSCR+GKCsLCGcKTpVaPVElQVPDFSKGlVlKcVclChKCL-ulsEoYIRaKKEQIE...CEHGH	.............MsDCDLCGhulPTlhPVRVhtPhhchuYPEGVWKGLC-sCL-SApcTY.Eh..scspsus....ppGKCsLCGs+stlasVElplPsFpps...cshplChpCLc.spEsa...h+-....................	0	1	6	7
+10454	PF10622	Ehbp		Energy-converting hydrogenase B subunit P (EhbP)	FIGfams, Mistry J	anon	FIG124174 (Release 2.0)	Family	Ehb (energy-converting hydrogenase B) is an methanogenic archaeal enzyme that functions in one of the metabolic pathways involved in methanol reduction to methane.  This family contains subunit P of Ehb.	19.50	19.50	20.60	118.80	18.70	19.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.70	0.72	-4.03	6	26	2009-01-15 18:05:59	2008-04-28 16:16:51	4	1	26	0	17	23	5	84.10	58	91.35	CHANGED	LhP+hhhuLGGYIhET...........pFPaRNlIVsNPTsEPIKIEVPsaD-pWIEcH+cLGLhVVPVs-DDDFluha+MsccKlc+u	.LLPKhsMSLGGYIRETh.......t..pFPYRNlIVGNPTsEPIKI-VPsYDEsWIE+H+cLGLIVVPVpc-DDFVGlF+hVcpKlcc....	1	3	7	13
+10455	PF10623	PilI		Plasmid conjugative transfer protein PilI	FIGfams, Mistry J	anon	FIG136100 (Release 2.0)	Family	The thin pilus of plasmid R64 belongs to the type IV family and is required for liquid matings.  pilI is one of 14 genes that have been identified as being involved in biogenesis of the R64 thin pilus [1].	19.70	19.70	19.80	26.20	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.83	0.72	-4.05	2	72	2009-01-15 18:05:59	2008-04-28 17:04:57	4	1	62	0	0	21	0	80.10	63	92.57	CHANGED	Mstp...+hplllhsspCc++l..h.sspD.s.hhh.FpTsDNsLllVhpssRhlhRhERhPGSpCcW+cso.u.+p+.ps.L	......MPQQHPGRLQlLVVDsHCKR+LFSTKTsTDPDELARRFCTPDNCLVVVLpsNRFLFRLERAPGSHCR..W+KGSpSRHQHLQDWL.......	0	0	0	0
+10456	PF10624	TraS		Plasmid conjugative transfer entry exclusion protein TraS	FIGfams, Mistry J	anon	FIG105028 (Release 2.0)	Family	Entry exclusion (Eex) is a process which prevents redundant transfer of DNA between donor cells.  TraS is a protein involved in Eex.  It blocks redundant conjugative DNA synthesis and transport between donor cells, and it is suggested that TraS interferes with a signalling pathway that is required to trigger DNA transfer [1].  TraS on the recipient cell is known to form an interaction with TraG on the donor cell [1].	25.00	25.00	42.70	31.60	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.24	0.71	-4.68	2	81	2009-01-15 18:05:59	2008-04-29 14:53:22	4	1	66	0	1	44	0	147.20	75	98.09	CHANGED	MKNLApIsLVTVlQFIACYLA-WGsAETshILhFllLWQGLFIWLF.QIRKKpplSDEFKFSKGlWYllMPVsSLLSPLLSLMlFIhGTLYELRRlSGClSl+EWhpsQls-QhsEDhtLDF-sVpac.ssaY..NPuTGhsMHGGhDSAGNTFGopWQD.sDR	...................M+sLsHIsLVTVIQFIACYLAsWGsAETlFhLhFIVLWQGLFIWLFSQI..RKKRsVSDEFKFSKGVWYIhMPVSSLLSPLLSLMVFIIGTLYELRRVSGClSl+EWMQSQVN.EQsNEDLHLDFDslp...sDFYRTNPATGLPMHG.GhDSAGNTFGosWQDYsDR.....................	0	0	0	1
+10457	PF10625	UspB		Universal stress protein B (UspB)	FIGfams, Mistry J	anon	FIG002192 (Release 2.0)	Family	UspB in Escherichia coli is a 14kDa protein which is predicted to be an integral membrane protein.  Overexpression of UspB results in cell death in stationary phase, and mutants of uspB are sensitive to ethanol exposure during stationary phase [1].	25.00	25.00	61.00	60.80	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.47	0.72	-4.27	8	648	2009-01-15 18:05:59	2008-04-29 16:18:06	4	1	646	0	50	149	0	97.70	80	96.31	CHANGED	MISGDsILhALhlVTslNhARYlSoLRsLLalMR-ucPLLYQQVDGRGFFTTHGNhoKQlRLapYI+opEYLcHHDPlFstKC-RVRcLFILoSuLlulsllshFhl	.MISs.slhaALhlVshlNMARYFSSLRALLVVLRsCDPLLYQYVD.GGGFFTSHGQPNKQVRLVWYIYAQRYRDHHD-EFIRRCERVRRQFILTSALCGLVVVSLIAL.....	0	2	11	30
+10458	PF10626	TraO		Conjugative transposon protein TraO	FIGfams, Mistry J	anon	FIG055244 (Release 2.0)	Family	This is a family of conjugative transposon proteins.	25.00	25.00	26.10	25.90	20.20	22.20	hmmbuild  --amino -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.94	0.71	-4.86	11	300	2009-01-15 18:05:59	2008-04-29 16:58:48	4	1	111	0	28	251	2	162.60	48	87.16	CHANGED	LPGMKGlplTuGM..sDGh+h.pscs-hGYtFGlAhoTYsKssN+WVhGuEYLpKpaPY+shpIPluQFTuEGGYYashLSDssKshFlslGhSALuGYEoVNhGcpLL.DGusLpcpDuFIYGGAlTLEhEsYLoDRllLLlpsRERsLaGoDsG+FHsQaGlGlKhIl	................LPt.+GlElpuuh..s-Ghp...ststhsYthGhAlosYsKpuNpWlhGuEYlp+phsY.....+s.......hpI..PltQFTuEGGYaaplLSDspKslFlhhGhSALAGYEol.NhGcKlL.DG..uTLtc+DsFlYGGAlTL-lEsYLoDRlsLLhpsRERhLaGuDst+FHsQhGlGlKFhl................................	0	7	24	28
+10459	PF10627	CsgE		Curli assembly protein CsgE	FIGfams, Mistry J	anon	FIG091002 (Release 2.0)	Family	Curli are a class highly aggregated surface fibres that are part of a complex extracellular matrix.  They promote biofilm formation in addition to other activities.  CsgE is a non-structural protein involved in curli biogenesis [2].\	      CsgE forms an outer membrane complex with the curli assembly proteins CsgG and CsgF [1].	25.00	25.00	35.50	27.90	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.06	0.72	-4.23	20	509	2009-01-15 18:05:59	2008-04-29 17:28:52	4	1	505	0	44	135	11	103.40	76	77.48	CHANGED	ElsGLllDRTloRhG+DFYhhFSsta+-ls..stshNLolcEpssupuGShlsVphspcsIYpTalu.pppslccpAppAlthVhptlsphphpt.....sosDLu..pDEh	........EVPGLLTDHTVSSIGHDFYRA..FSDKWES-Y....TGNLTINERPSARWG.S.WITITVNQDVIFQTFLFPhKRDFEKTVVFALlQTEEALNRRQIsQuLL..STuDLA+DEF............	0	8	16	31
+10460	PF10628	CotE		Outer spore coat protein E (CotE)	FIGfams, Mistry J	anon	FIG006437 (Release 2.0)	Family	CotE is a morphogenic protein that is required for the assembly of the outer coat of the endospore [1] and spore resistance to lysozyme [2]. CotE also regulates the expression of cotA, cotB, cotC and other genes encoding spore outer coat proteins [1].  The timing of cotE expression has been shown in Bacillus subtilis to affect spore coat morphology but not lysozyme resistance [3].	25.00	25.00	28.60	78.40	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.22	0.71	-4.91	9	180	2009-09-11 05:35:09	2008-04-30 14:11:34	4	1	178	0	35	94	1	178.80	59	98.44	CHANGED	MuE......YREIITKAVVuKGRKFTpuoHTIoPsc+PoSILGCWIINHpYcA.+KsGKsVElpGpYDINVWYSYscNTKT-VVTEpVpYsDllpLpYRDcssl.sD-h-VlA+VlQQPNCLEAsISssGsKIhVpVEREFlVEVIGETKVsVuVNPpspp-D.s....hph-hpD-EhE-lsPsFLtsppEE	.....MSEaREIIT.KAVVGKGR.K.aTp..STHTspsssc..P.T.SILGCWlINHpY......EA......+Ks......GKpVEI-GaYDVNsWYSacsNTKTEVVTERVsYsDpVslsYRDc.N.ap.uDDhElIARVIQ.PNCLEAhlSPNGNK..IVVpVEREFlsEVVGETKlCVuV..N..P-..Gss.-.sD-........-...apl..t.D..-EaE-LDPsFlV-s.E.............	0	13	25	27
+10461	PF10629	DUF2475		Protein of unknown function (DUF2475)	Coggill P	anon	SWISS-PROT(UPF0573)	Family	This family of proteins has no known function.	21.60	21.60	21.80	21.70	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.44	0.72	-3.73	19	290	2009-01-15 18:05:59	2008-04-30 14:19:30	4	7	77	0	189	287	0	56.90	28	33.47	CHANGED	sPthlPGYpGasPthtaphGp..TYGpsTtphhps.pstt.tp.h.............h.p..t.ssphhlspR	......thlPG...YsGasPth..+..ap..hGp..TYGpsTtphh..tt......t...................................t.....................................................	0	73	91	134
+10462	PF10630	DUF2476		Protein of unknown function (DUF2476)	Coggill P	anon	SWISS-PROT(UPF0572)	Family	This is a family of proteins of unknown function.\	\	\	    The family is rich in proline residues.	21.70	21.70	21.70	35.10	20.40	21.50	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.88	0.70	-4.51	3	61	2009-01-15 18:05:59	2008-04-30 14:48:06	4	3	21	0	35	65	0	234.80	48	96.78	CHANGED	M.GoRPsSPSADLAPhWu.QssGPoPAKRsRL.pEPAsPEsLAQPu.EDPA.....-shTShVhLsAGsALclPL-sVDLlLElpPhSVLpVSLQGHTlI..llPEsLtSSV.-hsht.tcuQPGh.s.s..GAtupD......VslppEoFCAsV.EhhhpE-ss-EDADsEFsEhWMsuPDDpAsGLasSusSl.SPhp-GQVPGPso.ussPuAEppSPRFIW-L-hsMLcPlPuSPLQPLPPSPSPNPQEQs.....LPsRPPC......KARRRL	...................................M.GoRPRSPSAp.sAPhWu.QPuGPu.PAKRhRL..cEP..AssEsh..ssPshEs..Pss..ssssLTS..lVVLuuGCALplsL-.-VDLVLEPtPTSlLpVSLsG..H..TLI..LlPEsLLuSs...tts.spssussGLEss.shLuA..tc-......Vllppt.FCuuVPElAsQE-A..h.-EDA..-spF.p.hhsussGpAuGL..asS..s..p..uh.uP..h.pu.hst.Pps...sssPusEppSPp.sha-L-h+LLEPhPoSPLQPLPPSP...S..PG.Pptcs...........hPt.pP......P...C......KARRRL.......................................................................	0	4	4	15
+10463	PF10631	DUF2477		Protein of unknown function (DUF2477)	Coggill P	anon	SWISS-PROT(UPF0574)	Family	This is a family of proteins with no known function. The family is rich in proline residues.	20.60	20.60	20.80	87.60	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.15	0.71	-3.96	3	22	2009-01-15 18:05:59	2008-04-30 17:09:40	4	1	20	0	12	26	0	135.90	75	92.45	CHANGED	MDPHEMVVKNPYAHISIPRAHLRPDLGQQLEsuPosSSSSEoQPLPVGoCsPEPltLLQsTEAPGPKGsKG.pGsAP.psQQAWQQPCNPYSSGQRPAGLTYAGPPPAGRGDDIAHHCCCCPCCSCCHCPRFCRCHSCCCl	MDPpEMVVKNPYAHISIPRAHLRPDLGQQLEsAss..oSSsEhQPLPsGsCssEPT+LLQPT.EsP.GPKG...s...KGspGAsPhQsQQAWQQPGNPYuSuQRPAGLT...YAGhPPlGRGDDIAHHCCCCPCCpCCHCP.FCRCHSCCCl.	0	1	1	1
+10464	PF10632	He_PIG_assoc		He_PIG associated, NEW1 domain of bacterial glycohydrolase	Naumoff D, Coggill P	anon	Pfam-B_97991 (release 22.0)	Domain	The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW1 but its actual function is not known. It is found on proteins which are bacterial galactosidases [1]. The domain is associated with the He_PIG family, Pfam:PF05345, a putative Ig-containing domain.	25.00	25.00	25.90	25.10	22.70	21.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.56	0.72	-7.11	0.72	-4.62	4	47	2009-09-11 10:36:46	2008-05-06 14:04:35	4	5	32	0	17	47	0	28.80	58	4.97	CHANGED	PpINsP+slGNYPuoPFLFYIPTSGpRPM	P+INuPpVhGspPuoPFLahIPsoGpRPM	0	11	14	17
+10465	PF10633	NPCBM_assoc	NPCBM-assoc; 	NPCBM-associated, NEW3 domain of alpha-galactosidase	Naumoff D, Coggill P	anon	Pfam-B_97993 (release 22.0)	Domain	The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW3 but its actual function is not known. It is found on proteins which are bacterial galactosidases [1]. The domain is associated with the NPCBM family, Pfam:PF08305, a novel putative carbohydrate binding module found at the N-terminus of glycosyl hydrolases.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.62	0.72	-3.93	29	604	2012-10-03 16:25:20	2008-05-06 14:23:52	4	85	329	11	233	617	92	78.10	22	12.53	CHANGED	spsGcpsslphshsssu.sssspslplslss.PsGWs...stssssphs...slssGpslpsshpVpsPssAsuGs....Yslpspsphs	..............................sGps.hshp.lsl.p.N.ps..ss......s..h..p..s...h..sls.h......s......s...P.sG.......Ws.........s....s..s...s....p.hs......sl.s............s..............G..........p.s.........ts....sshslss..Psss...sGs......Y..lshpst..s............................	0	110	180	223
+10466	PF10634	Iron_transport		Fe2+ transport protein	FIGfams, Mistry J	anon	FIG005173 (Release 2.0)	Family	This is a bacterial family of periplasmic proteins that are thought to function in high-affinity Fe2+ transport.	20.50	20.50	20.50	21.20	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.86	0.71	-4.32	30	560	2009-01-15 18:05:59	2008-05-06 17:09:52	4	1	550	30	101	300	159	153.60	53	80.44	CHANGED	AtAtEhPIGc...Ptph..sGMEluAVYLQPl-MEPp.Gh.....hssscoDlHLEADIHAsc..sNsNGFucG.-.WlPYLslsYpLpchsssc.spcGshMP.MVAsDGPHYGsNl.KL.......tGsGpY+lpapIpPPup......ttFGRHsDKETGV.........us..WFcPaslpY.-FpasG	...............................................................htEhPIGc.......Ppph..ssMEIAAVYLQPI-MEPc..Gh.....thsAucuDlHLEADIHAsc..sN.sGFu-G-..WhPYLs.lsYcLpppDoG......p.....h......pcGohMP.MV.A.s.DGPHYGsNl.Kh........GsGpYcLsahIpsPpp......tuatRHlDcET.G.V...........Gt....Wac..P..hslcY.-FpYsG.................................	0	26	56	85
+10467	PF10635	DisA-linker		DisA bacterial checkpoint controller linker region 	Murzin A, Coggill P	anon	Murzin A	Domain	The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by family DisA_N, Pfam:PF02457; the next 146-289 residues is this domain that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), thus forming a spine like-linker between domains 1 and 3. The C-terminal residues of domain 3 are family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis [1].	25.00	25.00	26.20	74.70	23.60	24.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.81	0.71	-4.70	39	608	2009-01-15 18:05:59	2008-05-06 17:13:32	4	5	605	8	154	378	117	145.50	42	40.47	CHANGED	LcDsusILs+ANQAlpTLEKY+ssLDcslssLssLEhEDlVTltDVspslQRhEMVhRIspEIcpYllELGsEGRLlshQLcELlss.l-p-thLlI+DYs.....pcshshpplhcplpslssp-Ll-hsslu+lLGYssssshlDs.l	....Lc-susILo+ANQAltTLE+Y+shLc-shssLotLEhEDhVTlpDVssVlQRlEMVhRIssEIptYlhELGsEGRLlpLQLsELlss.l-s-ttLll+DYh..................ppstshppsLppLppLoss-LL-hstlu.+hlGYssssph.Dp.............	0	67	124	144
+10468	PF10636	hemP		Hemin uptake protein hemP	FIGfams, Mistry J	anon	FIG024330 (Release 2.0)	Family	This is a bacterial family of proteins that are involved in the uptake of the iron source hemin [1].	25.00	25.00	30.90	30.40	24.10	16.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.53	0.72	-4.36	56	837	2009-01-15 18:05:59	2008-05-06 17:34:36	4	1	806	3	146	406	26	38.00	57	57.52	CHANGED	stlsocsLhp.GspplhIpHsGphYpLRlT+sGKLILTK	.......RplsSpsLLG.scu+llI-HsGQcYh..LRpTpAGKLlLTK...	0	25	79	112
+10469	PF10637	Ofd1_CTDD		Oxoglutarate and iron-dependent oxygenase degradation C-term	Wood V, Coggill P	anon	Pfam-B_18095 (release 22.0)	Domain	Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N in the presence of oxygen.  The domain is conserved from yeasts to humans. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts [1].	20.70	20.70	21.50	20.70	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.94	0.70	-5.26	39	253	2012-10-10 13:59:34	2008-05-07 10:58:38	4	9	224	4	187	298	18	273.60	28	46.78	CHANGED	s-lsaLhpYlsPpYLss-sh-clpcpFt-cSslpLccFLpschuspl+phlctp-pc...phPtpup-lpt..s...................WpsAtPPHKpRYhahcsps........t..pt..t...pEh.................................Lsslh.S.uF+KWLshlTul.pl..................................................sSpp..llsRRFR.G.DYTLAostc..........ttc.....stLEsoLsLT..Po..................................................sW-ss...............................................................EhGGYElYM...................ss-----...............................tDsAlY+u...................................................................s-pDDulLhopssuWNsLslVLRDpGlL+FVKYVStsAKGsRWDlospasVc..-p-.p-cpp	..............................................................................t.-hphLhcalsPsYLsschhpplpcpFp-p..SplpLppFLppchhpplpphlcpp-hp.....................................................WpsttPPpK++Yhhhptpp............................h.p.................................................h...h.hpLhpSpuFhphLu.hTuL.pl..................................................................................................................ssp.p...h.hRRa...+pG..cYTLssstp............................ttcstL-.hsLsls..ss..................................................uWps........................................................................................................-hGGaphYh....................spt.tt.......................................................t.th.pt..............................................................................................scs-Ds.Lhohsss.NpLslVhR.D.pusL+FVKYluppu.s....sp............................................................................	0	65	99	153
+10470	PF10638	Sfi1_C		Spindle body associated protein C-terminus  	Wood V, Coggill P	anon	Wood V	Domain	This C-terminal domain of spindle-body-associated protein Sfi1 has an important role to play in the bridge-splitting during bi-polar spindle assembly, and this separation event possibly requires interaction with integral components of the nuclear envelope, such as the Mps2-Bbp1 complex [1]. Centrally to this domain is a region carrying centrin-binding repeats with repeating units containing tryptophan, family Sfi1_central, Pfam:PF08457.	20.80	20.80	22.60	63.20	18.80	17.10	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.54	0.72	-3.62	5	21	2009-01-15 18:05:59	2008-05-07 13:35:04	4	2	21	0	13	21	0	108.00	46	11.30	CHANGED	+shslsc-LpTPhKoPs.ttusTIPGSERVK+a+MEslKs.RYSRARRA..IPSPIKSSsVLDSTlK++Ls.........ssstls-csTTststph.lccpsK+luSKV+cIcFs+IPp	.......hshpp-LcTPlR..oss..psusTIPGSERlKpaRMEAMKS.HYSRARRA..IPSPlKSSSlLDSTAKKpIs.........hcss.sslssssopshPhh...c+ps+NhsSKlc+IcFsRIPt..............................	0	1	6	12
+10471	PF10639	UPF0546		Uncharacterised protein family UPF0546	Coggill PC	anon	UPF0546	Family	This family of proteins has no known function.  Many members are annotated as potential transmembrane proteins.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.52	0.71	-4.26	16	235	2012-10-02 19:55:49	2008-05-08 09:31:42	4	5	195	0	151	384	13	111.00	33	75.97	CHANGED	LLlVullWGsTNPhl++uStGhppspps.......hhh-h+a.........LhpphcYhlPhllNQoGSVlFahsLscs-LSluVPlsNSLsFlhTllsu.hlLtEchhst+ohlGhhLVlsGssLCs	........................................................................hlhVuhhW.G.hT.sP..hl.++uu....ts.hpthpp...........h...p..hhtchth...........................................Lhhs.pYhl.PhllN......sG.S.lh.a.a..h..h...Lup.s............-LSLuVPlsN..SLuF.lFTllsu.hhltccl.h.u.p.p.s.hhGhhLhlhGlslC...................	0	44	77	117
+10472	PF10640	Pox_ATPase-GT		mRNA capping enzyme N-terminal, ATPase and guanylyltransferase	Coggill P	anon	Karlin D	Domain	This domain is the N-terminus of the large subunit viral mRNA capping enzyme, and carries both the ATPase and the guanylyltransferase activities of the enzyme. The guanylyltransferase enzymatic region runs from residues 242 (leucine)-273(arginine) [1], the core of the acitve site being the lysine residue at 260 [2]. The ATPase activity is at the very N-terminal part of the domain [3].	25.00	25.00	324.10	324.10	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.90	0.70	-5.64	14	75	2009-09-10 16:44:40	2008-05-09 14:14:22	4	1	47	0	0	67	0	314.60	67	37.27	CHANGED	hspssssc-lpHEVELlalpPPLlTLoNlh..sluoppESYIhFolss.tccpsKlRs+lPhS+lHGLDlKNsQLV-slDsIlWE+KoLlpEpc..l.c.ptsllRaSTEE+alFlDY.....K+ahSuI+LELVNllps+lKsll.VDFKlKYFLGSGAQuK..SSLLasLNH...PKs+PssoLEFEIlsp.s....pplspstLhsELpslh+tlF.MusscslhL.s.sthcsPl+ThMLKKQ-l.sl-L-sLYlToKTDGVhshVplsppulaCaFoHLsYhI+Yshp+pl-splhL..aGEAlK..tsphhslalIKlhpPt.........lsDRlcEtcalp-pL	.l-.QsSTAYEINNELELVFIKPPLITLTNVV..NISTIQESFIRFTVTN..KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIVWEKKSLVTEsR..L.H.KECLLRLSTEERHIFLDY.....KKYGSSIRLELVNLIQAKTKNFT.IDFKLKYFLGSGAQSK..SSLLHAINH...PKSRPNTSLEIEFTPR-s....EpVPYDELIKELTTLuRHIF.MASPENVIL.S.PPINsPIKTFMLPKQDIVGLDLENLYAVTKTDGIPlTIRVTScGlYCYFTHLGYIIRYPlKRhIDo.EVVl..FGEAVK...DKsWTVYLIKLIEPV.........IsDRLEEScYVESKL.	0	0	0	0
+10474	PF10642	Tom5		Mitochondrial import receptor subunit or translocase	Wood V, Coggill P	anon	Pfam-B_89651 (release 22.0)	Family	This protein family is very short and is only found in yeasts. Tom5 is one of three very small translocases of the mitochondrial outer membrane. Tom5 links mitochondrial preprotein receptors to the general import pore [1]. Although Tom5 has allegedly been identified in vertebrates this could not be confirmed.	20.20	20.20	21.40	21.40	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.20	0.72	-4.32	11	73	2009-01-15 18:05:59	2008-05-09 16:07:55	4	1	72	0	57	61	0	48.30	39	89.28	CHANGED	MFGs.stsQ.ScEEl+tpEcpAstTlppAshuAshLa..lSPhlhchl..pK..h	...MFGs.s..p.ScEEl+AtEtpAstTlppssssushLY......LSPhslchVp+..h.....	1	12	29	49
+10475	PF10643	Cytochrome-c551		Photosystem P840 reaction-centre cytochrome c-551	FIGFam, Mistry J, Coggill P	anon	FIG055090 (Release 2.0)	Family	A photosynthetic reaction-centre complex is found in certain green sulphur bacteria such as Chlorobium vibrioforme which are anaerobic photo-auto-trophic organisms. The primary electron donor is P840, a probable B-Chl a dimer, and the primary electron acceptor is a B-Chl monomer. Also on the donor side c-type cytochromes are known to function as electron donors to photo-oxidised P840. This family is thus the secondary endogenous donor of the photosynthetic reaction-centre complex and is a membrane-bound cytochrome containing a single haem group.	26.30	26.30	26.50	26.60	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.61	0.70	-5.06	7	19	2009-01-15 18:05:59	2008-05-09 16:46:09	4	4	15	2	16	20	1	172.00	39	84.60	CHANGED	MDNKSNGKLIALAlGGAVLMGALFFGVSFLTGYplPAENlSslLTPL+SFhGWFLLIFhASLIIhGLGKMSS+ISDKWFLSFPLoIhsIVAlMFs.L...W.+.........GRTTTlDGcYIRoVspLcAFL...................scPAsussVPsA.............PA.......................GhDFsAAKcLhss+CNKCHolsSVtDtL+.KY+KpGps-hlVhcMpuhPsSGIoccDsssIh.alsE...KY	...............................D.ppphpLhulAhhGAhhMGsLhahlShLTGa..PA.NhS.hLsPLpSFhGWhhLIhhuSlhIhshG+MSutISspWFlShPlshhhIVhlMFh.L...W.+.........G.RTTh.-Gp.IRoVtpLpta....................ppsshstphs.s..st................................s.shsuAcpLhst+CNc.CHTlcoVt-th+.+YcKpGpl-hlVp+MpshPsSsIoccDshpIh.YLpppa.........	0	1	7	13
+10476	PF10644	Misat_Tub_SegII	Misat_Myo_SegII;	Misato Segment II tubulin-like domain	Wood V, Coggill P	anon	Pfam-B_7826 (release 21.0)	Domain	The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins Pfam:PF00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils [1]. This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.64	0.71	-4.03	51	270	2012-10-03 12:11:42	2008-05-09 17:02:44	4	8	225	0	187	2002	14	111.20	33	21.93	CHANGED	+EIlTlQlGpauNalGoHFWNhQEuha..sYsspsp.......stl.spDVlaRp...Ghs..h.psphTaTPRlllhDLKGuhGoLpptut.LYp......................ptsp.tsssssWs.......s...phshpc.ps...htpspapps.L-p	.................+EllTlQlGph.uNal.usHaW.N.......h........Q.....-uhh.............shssppp..................s.l...sp.D..V.haRs.........Ghs......h.pGptTYTPRhllhDLK.G.u.h.G...o...Lpp...ss...LYp..........................tpt..sss.hhWp.............u...phshpp..p..hsps.Y..psLt.t..................................................................................	0	53	98	150
+10477	PF10645	Carb_bind		Carbohydrate binding	Wood V, Mistry J	anon	Pfam-B_63360 (release 22.0)	Domain	This is a carbohydrate binding domain which has been shown in Schizosaccharomyces pombe to be required for septum localisation [1].	25.00	25.00	26.80	39.00	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.09	0.72	-4.15	5	22	2009-01-15 18:05:59	2008-05-12 12:10:23	4	4	14	0	20	21	0	52.20	46	19.55	CHANGED	uoCGuApYDuupYVC.DsshLCPIlsGsPLpsCNGACYssShYuCoNGuLu.l	t.pCGsu.YDPupYlC....ssphLCPIssG.shphCsGACYsthhYsCsNssLs.....	0	8	15	19
+10478	PF10646	Germane	GerMN;	Sporulation and spore germination	Rigden D, Coggill P	anon	Rigden D	Domain	The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. The domain is found in a number of different bacterial species both alone and in association with other domains such as Amidase_3 Pfam:PF01520, Gmad1 and Gmad2.  It is predicted to have a novel alpha-beta fold.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.35	0.71	-10.70	0.71	-3.93	160	1597	2009-01-15 18:05:59	2008-05-12 17:01:59	4	13	985	0	421	1297	99	116.80	19	37.80	CHANGED	hslYa........hs...sssth..........Llspsphh...............shhptslppLl.pG.P.............hhsslPssspl...........h.slplp.....s.hshlshop.phhp....ssss.cph....h....ltsllhTLs.phs.t......lppVpl.hl-Gcshphht	..................................................................................h.plYa........hs.......pss.ph.............llspsptl.................sssps.hhptslptLl.pG....Ptst..............htssls..ss.spl............................h..shslp........ts.hspls.hsp..phhp.......hssp.tpph........h.ltpllh.TLs.phs.s.........lppVpl.hlsGp.h....h.......................................	0	178	338	387
+10479	PF10647	Gmad1		Lipoprotein LpqB beta-propeller domain	Coggill P	anon	Rigden D	Domain	The Gmad1 domain is found associated with the GerMN family, Pfam:PF10646, in bacterial spore formation. It is predicted to have a beta-propeller fold and to have a passive binding role rather than a catalytic function owing to the low number of conserved hydrophilic residues.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.71	0.70	-4.99	26	420	2012-10-05 17:30:43	2008-05-12 17:22:56	4	16	404	0	114	623	108	247.70	24	43.11	CHANGED	sGul................sp....hsuspssslsGshu..pst.shsSsAlStsuppsA.............uVs.......sssssLhlGshGussspsh....sup.....slocPSashs.sslWsVss.usssscllh......sss......Gpss........................stV-ssshs..........slsslplSRDGsRsAhll....s..uplhluslp+sssG...thtlssPhclsss.tpsssuluWtssssllVhspsssssV.h...VslDGutsssh.susshssslhusuussst.....lhsssssulhp.....spssphWpplsshhss....PshP	......................................................................................................Gthht......hss.tphp.h.s.GshG......pss.s.susAlut..s..s..p.....hsA................................uVs.............sstps..Lh.s..s.s.h...G..u.p.s.hpsh...............sGt......sL.s.+.P..oa.......s......h.......s...ss.........lW..sss-..sssslplht.......................ss..............Gpht...............................................phsV-.h.suhst.............tlsslpl....S.DGsRsAhll.......s....sp..l.hl...uhlp+spsu.......phhhshsh.phu..s....hs...slssluWhss.s.p..Ls.Vh..s..ps..s.ss..sVth.......lsl.DGus.......sss....ut...hsss.hsulsusssp.............lhls...s..stsll............tpts.tWppl.thhss.....s........................................................................................................................................	0	37	82	109
+10480	PF10648	Gmad2		Immunoglobulin-like domain of bacterial spore germination	Coggill P	anon	Rigden D	Domain	This domain is found linked to the GerMN domain Pfam:PF10646 in some bacterial proteins. It is predicted to contain an immunoglobulin-like all-beta fold.	25.70	25.70	26.30	27.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.78	0.72	-3.81	20	66	2009-01-15 18:05:59	2008-05-13 09:15:26	4	10	62	0	37	66	15	87.70	28	26.99	CHANGED	hplplppPpssshlsu......slpVpGp..Ap.sFEuslshclp-usupll.tcthspAssussuhGpFpsslshsss..ss.pupltVhpssspsGs...h	.................IhlhsPt.sshVsu......shpVpGp....Ap...sFEuslsh+l...hDusGpll.scshsp..As.su..usshGsFpsplshps.t.st..puhl..plaphSscDGo.h..................	0	22	31	36
+10481	PF10649	DUF2478		Protein of unknown function (DUF2478)	FIGfam, Mistry J, Coggill P	anon	FIG046046 (Release 2.0) 	Family	This is a family of hypothetical bacterial proteins found in the vicinity of Molybdenum ABC transporter ATP-binding gene-products MobA MobB and MobC. However the function could not be confirmed. This family appears to belong to the P-loop superfamily by alignment to Pfam:PF03266. However, the characteristic P-loop sequence motif appears to have diverged beyond recognition in this family.	22.10	22.10	22.30	22.10	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.80	0.71	-4.90	57	205	2012-10-05 12:31:09	2008-05-13 16:49:41	4	3	152	0	78	206	9	157.00	37	79.33	CHANGED	lAAlshsss..sss.DtlLsshAtcLtup.GhRluGlV............Qtp.....tptssppsshp.lpsL.ssGppltIoQsLGsuupuCRLDsuuLspAsutlppAlsps..sD........LlllN+FGKpEupG+GhpshIspAlutslPVLsuVsppthcsWppFuuuhustLss-ppultsW	.....................lAAlhh.s.ps.sss.DsLLuphAtchppp.GlRluGhl........................Qpp.h...tssppspp.chc.lccl.soGt.p..hhI......S......Q...s....LGs..GS.....p..G..C..R..L.....DPuu....LA.c.A....u.u.sltsslpsu...sp........LLllN+FGKtEs-G+GhR.shItt.Ahut.sIPVLTsVsp.phl-u.W.c.cFuGshushLsssppulpsW....................................	0	13	38	55
+10482	PF10650	zf-C3H1		Putative zinc-finger domain	Wood V, Coggill P	anon	Wood V	Domain	This domain is conserved in fungi and might be a zinc-finger domain as it contains three conserved Cs and an H in the C-x8-C-x5-C-x3-H conformation typical of a zinc-finger.	20.90	20.90	20.90	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.40	0.72	-6.75	0.72	-4.45	14	159	2009-01-15 18:05:59	2008-05-14 12:01:54	4	9	125	0	107	155	0	22.10	48	1.64	CHANGED	hlC.aElsGthCNDcsCpaQHh+	...hC.a-LsG.sCNDc-CpaQHh...	0	31	47	76
+10483	PF10651	DUF2479		Domain of unknown function (DUF2479)	FIGfam, Mistry J, Coggill P	anon	FIG015005 (Release 2.0)	Domain	This domain is found in phage from a number of different bacteria.  It is purported to be a putative long tail fibre (Bacteriophage A118) protein, but this could not be confirmed.	21.10	21.10	21.20	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.66	0.71	-4.74	17	665	2009-01-15 18:05:59	2008-05-14 14:45:55	4	14	402	19	25	471	10	166.10	25	34.80	CHANGED	M....lpKhss.l-hphssphpshhstsIpFaspDp.sTAhlpFpls+cshPLslSptpscstlhLhhsss........hhhtslclhDsh..pGhlpYslPschlKp..sGpVpuplalp.p......sspslshtp.FoFpIccuLlsphss.ht.hYIcpF-clcchlpcphpcl..........cpslspspshhpp	...................................M......K..t.lphp.psph.sl.s....hsI.pF.h.ptDp.sou.sLphs.l.s.c....ss........t........s............lsLosp.tlps.clslhtcss.......t.hhsc...s...l.p...IlDsh..cGhlpYhlPschlcp..sGplcAplh.lpp.........ss...ps....l...s.s....pp.FoFslp..cuh.lsshsutph.sY.l...hsh.....pcl.....hchlp....cphpph.............cpshpphpp....p......................................................................	1	9	17	25
+10484	PF10652	DUF2480		Protein of unknown function (DUF2480)	FIGfam, Mistry J, Coggill P	anon	FIG020045 (Release 2.0) 	Family	All the members of this family are uncharacterised proteins, but the environment in which they are found on the bacterial genome suggests a function as a glucose-6-phosphate isomerase (EC 5.3.1.9).  This could not, however, be confirmed.	25.00	25.00	114.20	114.10	24.20	19.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.00	0.71	-4.68	18	81	2009-01-15 18:05:59	2008-05-14 18:13:37	4	1	75	0	40	88	197	167.00	47	98.13	CHANGED	M..t-...EIlNRVANSpLhTFDLEDaYPcGpRhhlDIppWLh-GllL+EK-FRptlKsHDWSpYpcpaVAlaCSTDAIlPuWAYMLlsspLpPaApKVVhGsL-sLEohlYp-llsplDlssacs+PVIIKGCScKPVPpsAYlhlhpKLQPVAKSlMYGEACSoVPLYK+	........-EI.lN+VA.pSsLlsFDLE-aYPpG.cR.h.hhDIcsaLapGhlL+EK-FRptlKpaDWopYpspaVAlhCSsDAIlPsWAYMLlsspLpPaA+cllhGsh-pLEptLapchlsplDhopapDc.VllKGCoccsVPpsAYlhhsp+L.pPlsKSlMaGEsCSoVPlaK+.........	0	17	36	40
+10485	PF10653	Phage-A118_gp45		Protein gp45 of Bacteriophage A118	FIGfam, Mistry J, Coggill P	anon	FIG0160151 (Release 2.0)	Family	This domain is found in bacteriophage and is thought to have a gp45 function within the phage tail-fibre system.	21.60	21.60	21.60	79.80	19.40	18.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.05	0.72	-4.11	2	34	2009-01-15 18:05:59	2008-05-16 10:25:53	4	1	26	0	1	17	0	60.50	87	100.00	CHANGED	MsERVFRKpT.FGsSEIahssRTKMIANPAFpQKIPL.ETGC-pMsDYIEELKLKGYEEVTR	MTERVFRKpT.FGsSEIahssRTKMIANPAFpQKIPL.ETGC-pMsDYIEELKLKGYEEVTR	0	1	1	1
+10486	PF10654	DUF2481	DUF2482; 	Protein of unknown function (DUF2481) 	FIGfam, Mistry J, Coggill P	anon	FIG020094 (Release 2.0)	Family	This is a hypothetical protein family homologous to Lmo2305 in Bacteriophage A118 systems.	25.10	25.10	25.90	83.80	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.61	0.71	-4.44	4	25	2009-01-15 18:05:59	2008-05-16 11:19:24	4	1	20	0	1	17	0	126.00	65	98.31	CHANGED	sVMElTENKARQREIISYlsNpsLshs-hKcLQKELNpLMNcNTEEKpKTaWsKThcRlVtNKpWp-ITltEFl-LRHAGLos.AIADaFplS+uslFNaT..pcN+pEYa+hFshs.YpKsKEhWsD	..sVMEhTcsKARQREIISYIsNNDlpLs-LhcLQKELNpLMNENT.EKQKTYWoKTFDRIV++KcWsEITIpEFs-LRNAGLTsYAIA-HFKVSKulVFNYT..QRNKKEYYplFDMsEYQKNKEhWND......	0	1	1	1
+10487	PF10655	DUF2482		Hypothetical protein of unknown function (DUF2482)	FIGfam, Mistry J, Coggill P	anon	FIG030041 (Release 2.0)	Family	All the members of this very small, very short family are derived from bacteriophages, of the SA bacteriophages 11, Mu50B, system, and from the Staphylococcal_phi-Mu50B-like_prophages subsystem. All members are hypothetical proteins.	25.00	25.00	45.10	45.00	23.50	23.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.21	0.72	-3.95	4	148	2009-01-15 18:05:59	2008-05-16 11:42:32	4	1	106	0	1	35	0	98.00	70	98.61	CHANGED	MTKNYKDMTQ-ElRDLLuEKsGELYELspEIccETEFDlLLFSolGVssGDhluSSpsALGsshsLAsLLcNpssacDlsNVIpMpKLQKhLGlDDsKED	..MTKNYKDMTQEElKDLLSEKoGELYELAKEIKtEocFDILLFSoIGVhDGDaluu.SsSVIGcsFDLAsLLDsscuY+DIlNVlQMpK.QKhLGIDDsKED......	0	0	0	1
+10488	PF10656	DUF2483		Hypothetical protein of unknown function (DUF2483)	FIGfam, Mistry J, Coggill P	anon	FIG032091 (Release 2.0)	Family	This is a family of proteins found in bacteriophage particularly of the SA bacteriophages 11, Mu50B, family, homologous to phi-ETA orf16.	25.00	25.00	41.10	41.00	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.42	0.72	-3.90	7	131	2009-09-11 01:17:25	2008-05-16 13:49:18	4	1	122	0	4	32	0	71.50	78	98.11	CHANGED	M.KpTV...TYlIKhKDt..sLYITN+PTstpsT.pYSss+pcAREFsGh--ssIDMstHpAIKKTVTETpEYEEVth	...M.KQTV...TYIIRHRDM..PIYITNKPTDNNSDISYSTNRNRAREFNGMEEASINMDYHKAIKKTVTETIEYEEVEH..........	0	1	1	4
+10489	PF10657	RC-P840_PscD		Photosystem P840 reaction centre protein PscD	FIGfam, Mistry J, Coggill P	anon	FIG031038 (Release 2.0)	Family	The photosynthetic reaction centres (RCs) of aerotolerant organisms contain a heterodimeric core, built up of two strongly homologous polypeptides each of which contributes five transmembrane peptide helices to hold a pseudo-symmetric double set of redox components. Two molecules of PscD are housed within a subunit. PscD may be involved in stabilising the PscB component since it is found to co-precipitate with FMO (Fenna-Mathews-Olson BChl a-protein) and PscB. It may also be involved in the interaction with ferredoxin [1].	23.40	23.40	23.60	117.30	22.40	23.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.77	0.71	-4.35	8	13	2009-01-15 18:05:59	2008-05-16 14:15:59	4	1	13	0	11	13	0	142.40	66	98.98	CHANGED	MQsQLSRP.TusNQVRsSs.................SGPWSGNAAHKAEKYFITSAKRD+pGpLQlpISPASGRRKLSPTcEMIsKlIuGEIELaVLTTQPDIuIDLsQKVLDNENRYVIDFDKRGVKWTMRDIPVFYcSL+ppLCVEIDRpoYTLDEFFK	...MQsQLSRP.TusNQVRtSs.................SGPW.SGNAsHKAEKYFITSAKRD+ps+LQlpIsPASGRRKLSPTpEMIsKlIsGEIELaVLTTQPDIAIsLppKVLDNENRYVIDFDKRGVKWTMRDIPVFYsohp+pLCVEIDR+sYTLsEFFK	0	1	2	8
+10490	PF10658	DUF2484		Protein of unknown function (DUF2484)	FIGfam, Mistry J, Coggill P	anon	FIG030013 (Release 2.0)	Family	A role of this family in UDP-N-acetylenolpyruvoylglucosamine reductase, as MurB, could not be confirmed.	25.00	25.00	25.80	52.30	23.30	19.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.78	0.72	-3.86	23	57	2009-01-15 18:05:59	2008-05-16 17:16:29	4	1	43	0	11	57	5	75.80	44	91.47	CHANGED	Ms....luLhLuslWslsAsllAhLPSRppHWptAal..LlAlGlPLLGaVsapsGPhhGlhsLsAGhSlLRWPVhYlh+hlR	......MshSLlLAslWslsAsllAhLPuR.pHWptAhl..LIusGlPLlGaVsappGPahGlhsLhAGhShLRWPlhYLh+hlR..	0	1	8	9
+10491	PF10659	Trypan_glycop_C		Trypanosome variant surface glycoprotein C-terminal domain	Bateman A	anon	Pfam-B_1351 (release 3.0)	Domain	The trypanosome parasite expresses these proteins to evade the immune response.	21.40	4.60	21.60	4.70	21.30	4.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-11.30	0.72	-3.70	103	238	2009-01-15 18:05:59	2008-05-17 14:12:18	4	6	9	2	67	241	1	95.60	29	21.67	CHANGED	C.tt.tpspspCp.....p.ssCpas..ppppcsp..Cchppsp....tppps.tsstttt.........stppsp+C.ttcp.cscCtp.s...........CKW..-sppC..KDSShLlsK+hAL..huuAFlAL........LF	..............................................C..pthpppppCp...pttCpap..tptpptc....Cp.pppptppps.sssststs........spsssppCps+p..cscCcp.s.....................CpW...........-tppC......+-SShLlsKpFAL..huAAFsuL.L.............................	0	0	67	67
+10492	PF10660	MitoNEET_N		Iron-containing outer mitochondrial membrane protein N-terminus  	Coggill P	anon	Wiley S	Domain	MitoNEET_N is the N-terminal region of the MitoNEET and Miner-type proteins that carry a zf-CDGSH, Pfam:PF09360, redox-active 2Fe-2S cluster.  The whole protein regulates oxidative capacity. The domain is an anchor sequence that tethers the protein to the outer membrane.	21.30	21.30	21.30	26.70	20.60	17.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.95	0.72	-4.12	9	136	2009-01-15 18:05:59	2008-05-19 13:08:18	4	2	85	3	88	127	1	53.10	38	42.79	CHANGED	M..pslSpllps.hPthLttlPlPcohtshh+Lshp-WLsLlshsussAulGYlsY+sFhsKc+pp	..................hp..hs.hhtthPhPpohtsahp.LshpEWltLl.PhhuslAslGYLAh+sFhsKc+p...............	0	20	25	48
+10493	PF10661	EssA		WXG100 protein secretion system (Wss), protein EssA	FIGfam, Mistry J, Coggill P, Desvaux M	anon	FIG043089 (Release 2.0)	Family	The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (Pfam:PF06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (Pfam:PF10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (Pfam:PF01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria [1].	21.00	21.00	21.80	21.60	20.90	20.30	hmmbuild  --amino -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.95	0.71	-4.52	4	267	2009-01-15 18:05:59	2008-05-19 16:20:43	4	1	265	0	8	83	1	130.50	47	86.05	CHANGED	ItuuADSYLpcsGKhchKlDRlpcocpEKNc..cthcETELDKsuIpLFssEh-cclpcKppsEpc-h-clcsuLF.cphcss.sVK-TKcpLFSu-Y.ssu..schApo....EspTcsshS.sllhhhuGsllhlCsGlYslhR+lac	................tshh.slssp............................pcE...Ec+hss-Lsp.YDTTLFNKD.sKtVN-.s..htcpK.c-.pQpIKNchFQNQ.A.S+u..T.RL..s...ET.KKVLFSK...o.NlpKo...oESDKS..PYI..QNKQEKpIaP.Y.ILhSlGA.hLTLGhlI.........FsIa+t.....................................	2	2	4	7
+10494	PF10662	PduV-EutP		Ethanolamine utilisation - propanediol utilisation	FIGfam, Mistry J, Coggill P	anon	FIG047026 (Release 2.0)	Domain	Members of this family function in ethanolamine and propanediol degradation pathways, however the exact roles of these proteins is poorly understood [1-3].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.59	0.71	-4.70	20	1157	2012-10-05 12:31:09	2008-05-19 16:22:45	4	8	759	0	91	4581	2185	127.50	43	87.54	CHANGED	MK+lhLlGtoGsGKTTLsQsLpG.....c-L.+Y+KTQulcapsss.IDTPGEYlEsRpaYsALhsous-ADlIuLlhsAsp.hssFsPGFuuhFsKPVIGIlTKlDLu.sppplphscphLppAGApcI.FclSulsspGl-ELhsYLpp	..........................................................................MKRlh.h..lGsstsGKTT.Lh.pu.L.pG....................p...h........hh.........+......K............T........Q...........A..........l...............E.............a.............s.............s.............p...........s.........I...............D........T.......P...G..........E........Y.........h........p........p..................p........h.......Y....p.....A........L........l.......s......o........h........p.........-.....s.........D......h.....l....h..h.V.h...s........A........s........s........................t.......o.....h.......h...s.......s.....G.......h......h.........s.......h.......h........s........+..........h.....I............u......l......l...o...KsD.h...s...............s.....t...c......l.....u....h....s.....+.....p...h.....L........p.......c........s........G......h........c........c........I........F.........l..suhsspuV.ppLhcaLt.s..........................................................................................................	0	46	65	79
+10496	PF10664	NdhM	DUF2485; NADHqo1-M; NADHdh-M;	Cyanobacterial and plastid NDH-1 subunit M	FIGfam, Mistry J, Coggill P	anon	FIG006356 (Release 2.0)	Family	The proton-pumping NADH:ubiquinone oxidoreductase catalyses the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides.  Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 sub-complexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1]. The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms [2]. The three subunits of NDH-1, NdhM, NdhN and NdhO are essential for effecting cyclic electron flow around photosystem I, by supplying extra-ATP for photosynthesis in both plastids and cyanobacteria [3, 4].	19.80	19.80	20.90	90.80	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.31	0.72	-4.14	21	90	2009-09-11 07:47:26	2008-05-23 11:37:31	4	1	84	0	43	86	121	108.50	58	75.56	CHANGED	LKsTTRHVRIFTAcVc.ss-Llsss..spLTLDlDPDNEFlWs-sulpKV.p+FcELV-utuGp-Lo-YNLRRIGSDLEtaIRpLLQsGEluYN.suRVLNYSMGLPRssp	.LKSTTRHlRIasAclc.ss-Llsss...spLTLDlDPDNEFlWs--ulpKVYp+FcELV-shsG...t-Lo-YsLR+IGSDLEHaIRpLLQsGElSYNhsuRVlNYSMGLP+lt.t....................	0	7	27	38
+10497	PF10665	Minor_capsid_1	Phage_Gp9;	Minor capsid protein	FIGfam, Mistry J, Coggill P	anon	FIG016324 (Release 2.0)	Family	This is a putative tail-knob or minor capsid protein from bacteriophages.	25.00	25.00	25.60	25.30	23.50	21.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.40	0.71	-4.24	5	90	2009-12-03 14:34:41	2008-05-23 13:52:04	4	1	89	0	7	71	0	111.50	28	97.94	CHANGED	Mlht.PlPhchLIHoloYcEY..hGEDca...GpssYuKPllIE+VRVsPscchssuosucolhaNAVlFlDulNS.sPhhpFpc...pSKIsFcGK-asIpKVIPsYss.ScslHHaELEVl	.............................shchLlcslphc..th...t.s.c.sca...spss.YscslpIcpVRhDh.......s.......pshsss......ssu..cptths..ul.....IFl.sshS..ssh.s-hpp.....tu+lh.....as.G.c.-Y.sIscl.ssYts.s.splapaElEV..........	0	2	6	7
+10498	PF10666	Phage_Gp14		Phage protein Gp14	FIGfam, Mistry J, Coggill P	anon	(Release 2.0)	Family	This phage protein family is of unknown function but is expressed from within a cluster of tail- and base plate-producing genes [1].	21.30	21.30	21.70	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.80	0.71	-4.32	2	24	2009-12-01 14:53:38	2008-05-23 14:29:37	4	1	22	0	1	16	3	127.00	72	98.20	CHANGED	MsQNNVINIQLEESYQEFQLGTELFRVGLGDcMRRKWIEADEKYKKKLEKLNKYNIDNTDEMSSE-YFsLEEDVKEALTEAYAlLLDDEcAFsKCYtQCKDILKMYQVYsQVAE.IVGSVEKQQNEIQKKYKAKMTKKAK	....MsQNNVINIQLEESYQEFQLGTELF+VGLGDEMRRKWIEADEKYKKKLEKLNKYNIDNTDEMSSE-YFsLEEDVKEALTEAYAlLLDDEcAFsKCYtQ.CKDILKMYQVYsQVAE.IVGSVEKQQNEIQKKYpAKMTKKAK...........................	0	1	1	1
+10499	PF10667	DUF2486		Protein of unknown function (DUF2486)	FIGfam, Mistry J, Coggill P	anon	FIG008383 (Release 2.0)	Family	This family is made up of members from various Burkholderia spp. The function is unknown.	21.50	21.50	22.30	21.50	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.90	0.70	-3.83	10	64	2009-01-15 18:05:59	2008-05-23 16:06:39	4	2	63	0	15	70	3	213.10	43	94.62	CHANGED	MopspssS...IPsLTDVLVPG+......Ps.ARuouuDss.........s+DsAAhPlLss..s.s.t.susut.....ccspsssc.lsscPlPoPclssVthPuc...................sDAPAcPu..uut+VluccAsAhpAPhPssLAsDsstsssuuAs...........hsAu-sA...PcussPuAsssussphutA............sspsAAshTs.DAppIAERLRsRlTsYLTG-GR-sIEARCRDALH-HouWLVGQITREVALALETEVhcWVR-AVcEEIARRsuG	..................................MspspssS...IPsLTDVLVPGp......Ps.ARssuusss............................pAu.P..............sssu...............pp.....sttpscss.sscPsssst..sssst.hPss...................pDAshtPu..st.cssA.tt.uhthPhsssLAs-.....s.s.shsAh.............h.AscsA...Pch...ssPAAhssssPtlsps....................................................Asu.hhss.h-AppIAERL+uRhTpYLTGEGRulIEARCRDALH-HuuWLVGQIsREVALALETEVhsWVp-AVsttLARRpss..........	0	1	2	7
+10500	PF10668	Phage_terminase		Phage terminase small subunit	FIGfams, Mistry J, Coggill P	anon	FIG022212 (Release 2.0)	Domain	This family of small highly conserved proteins come from a subset of Firmicute species. Its putative function is as a phage terminase small subunit.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.94	0.72	-4.19	6	212	2012-10-04 14:01:12	2008-05-23 17:12:29	4	8	173	0	19	242	9	60.70	37	24.56	CHANGED	MARpRsPcRDcAhchahESuGsh.LhDIAscLslssSQIRKWKupDKWs-.......p........hNuslT.......ppK	....................MsRt..RsP.p.....RDpAhcla...hc...ssGphpL+-I..AscLs......Vo.s.....upIR.....+WKopD.K...Wsp..............p.......hpussp...............................	0	5	13	15
+10501	PF10669	Phage_Gp23		Protein gp23 (Bacteriophage A118)	FIGfam, Mistry J, Coggill P	anon	FIG018382 (Release 2.0)	Family	This is the highly conserved family of the major tail subunit protein.	22.60	22.60	23.70	26.80	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.54	0.71	-4.00	3	16	2009-01-15 18:05:59	2008-05-23 17:22:57	4	2	15	0	2	7	0	120.90	88	55.90	CHANGED	MYEGLTKVFDYALAKEMFFAALFVALFIILLIITKRIWDDSKIVRVEMKEERDKMETEREKRDKESKEERDKFISTMNEQQRLMDKQNDMMGQQQQSIDSLSKSVGKLAHKVDLLEHKITK	.......MYDGLTKVFDYALAKEMFFAALFVALFIILLIITKRIWDDSKIVRIEMKE.EREKVEEEREKRNKESKEERDKFISTMNEQQRL...MDRQNDMMKQQQQSIDSLSKSVGKLAHKVDLLEHKITK...........................	0	1	1	2
+10502	PF10670	DUF4198	NikM;	Domain of unknown function (DUF4198)	Coggill P, Bateman A	anon	Pfam-B_42996 (release 22.0)	Family	This family was previously missannotated in Pfam as NikM.	34.00	34.00	34.00	34.00	33.80	33.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.44	0.70	-4.34	108	1021	2009-09-14 15:50:14	2008-05-29 08:59:34	4	7	729	0	303	893	241	211.50	19	81.58	CHANGED	ApAHthWlhPssshl.ssst.sh.htlthspshsssh...........................shph.......hsP............cGp.sshhp.......shtts.ptt.h..............ptssaplsh....thptsshashhhpst.hhpppt.....................s....sphhhphsKshl.......stsssspshppsh..GhslEllPls+P.ss....lhsGpshphpll.hcG+Phss.scVplhhtstchpsp..................shtlpTDssGhhohshspuGhahhsAhhpsst	..................................................................................................................AtAHthal.ss......p.....h..pttt..........htlha.s.c..shptt.h..tt....................................................shph...hps................sGp....tsh.t......................phtphph.........................ppssatlsh..........thp..s.uhas..h.hhps.h..h.hphpp...........................................t...sphhhphsKshl........p..t...s..s...p..t..h...p..psh....GhslEllPlsc.......P...s......lhsGps.....hphpll.hcG+Pls..s..splplphtsh.h.p.t....................................................shphpTD.s.pGhhshshspsGha.hhts.hpt..h...........................	0	105	215	264
+10503	PF10671	TcpQ		Toxin co-regulated pilus biosynthesis protein Q	FIGfam, Mistry J, Coggill P	anon	FIG032035 (Release 2.0)	Family	The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonisation in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localisation of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.	21.50	21.50	21.60	21.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.74	0.72	-4.10	60	393	2009-01-15 18:05:59	2008-05-29 13:17:40	4	6	315	2	76	322	9	85.90	27	34.59	CHANGED	stsaphp.sspsLcpsLpcWApps........GWplh...Wp.sst..Da.lsushsasG..sFpp.........Alpplhps..hpssshslpsshat..usplltlspht.............p	............s..tWph..sssTL+psLpcWApps...........sWplh...Ws.ssh........-apl-uslsapG..sFcs.........Alpplhph..h..p...sspt.s....lhsph.p......tppllhVss....pp.................................	0	19	40	58
+10504	PF10672	Methyltrans_SAM		S-adenosylmethionine-dependent methyltransferase	Coggill P	anon	Meireles D	Family	Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyse the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalysed by the S-adenosylmethionine-dependent methyltransferases.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.82	0.70	-5.56	3	4405	2012-10-10 17:06:42	2008-05-29 15:15:01	4	12	3015	23	953	3434	475	251.00	27	55.36	CHANGED	RRLFHGRGRpWPGLEQITCDWLQGQLLVNLFKEVDDAFLuuLKcGLsALsuuslWAoKQGRolVLQHRYADGAPSEVLlGELs-oPVVVEsGLKYQLDIGRNQNFGLFLDMRhGRcWVQENAKuKNVLNLFAYTCGFSVAAIAGGAcQVVNVDMARGSLSKGRDNHRLNGHDlspVSFLGHDIFKSWGKIKKuGPYDLVIIDPPSFQKGSFALTKDYKKILRRLPELLsEGGpVlACVNSPAVoPDFLIEoMAEEAPsLcFlERLDNPPEFsDVDs-AuLKVLLFR	.........................................................................................................h.htt.............................................................................................................................................................................................................................t....t....h..h...h..G....c...h..s..p..h..h.....l....p....E...p..G....h....+...h.h.Vs...l.p..c..s..h.cTGlFLD.pR....t.s....R......p........h.......l.......t........p.....h............u.........c.......u........K...............c.......VLNh.F.oYTGu...FoV..t..A.u...h..G........G..A...p.p.ss.oVDh.SppuLch.u.c.....c.N.h.p.LN........u.......l.......s.....h......p......p...t..............c...............h....l...p...s.......D.....s.......F.................c...h....h.........p....p......h...........c....c........p.........t...............p...a.DlIllDPP...........s..F......s......c......s......p......h....s.....l.....p...+...s...Y....t...c...l........t...t....s....h....pl....L...p..s....s.G.h...l.h......h..s......ss......s.........h......................................................................................................................................tttp.hh.t..............................................................................................................	0	328	573	786
+10505	PF10673	DUF2487		Protein of unknown function (DUF2487)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	26.50	26.30	22.60	21.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.76	0.71	-4.39	15	163	2009-01-15 18:05:59	2008-05-30 11:09:48	4	1	162	0	32	124	0	137.50	48	89.88	CHANGED	l-pYLpu+-YIDTAlIPLlslsh..spchKphsppGEFstlLupElERQhKGRlhLhPuFTYlsssppptth..cLpcWpsclpppuFcHVhalTuDpsWK...ttpshpsp.llW.lPulPLEp.....................hscshK+cllc-plpQllshLhp+W	......lEpaEQAR-YVDTulIPLlSISs..ucchKpsVEQGEFlcLLShELERpaKGRVlLLPAFTYLs-.sQ+scps..RLp-WoscLpppGFKHIsYVTSD..hu...WK..pthp-lpGc.LhW.hPolsLEp.....................hsDptKREll+s+l+plhshL.pKW....................................	0	11	23	26
+10506	PF10674	Ycf54	DUF2488;	Protein of unknown function (DUF2488)	Mistry J	anon	PRODOM	Family	This protein is conserved in the green lineage and located in the chloroplast.	25.00	25.00	32.80	32.20	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-10.13	0.72	-3.86	24	115	2009-01-15 18:05:59	2008-05-30 11:33:57	4	2	101	7	50	116	96	90.40	50	67.26	CHANGED	sTYaalhASc+FLhpE...EPLEEVL+ERpRaYtEpsKcIDFWLVppPAF..LpuPEhupl+schPpPuAAllSTsspFIsaLKLRLEaVhpGpFEAP	.......pTYaallASp+FLl-E...EPh-ElL+ERhRpYtEpsKElDFWLVhpPuF..L.-ssphsclpt+l......sp......PusAlVSTstpFI.T.alKLRL-aVlpGpFEA.......	0	14	36	46
+10507	PF10675	DUF2489		Protein of unknown function (DUF2489)	Mistry J	anon	PRODOM	Domain	This is a bacterial family of uncharacterised proteins.	19.80	19.80	20.70	20.80	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.40	0.71	-4.47	51	301	2009-01-15 18:05:59	2008-06-02 09:38:11	4	1	297	0	73	216	44	130.00	39	84.44	CHANGED	IluLusYAshLLhpL+cQpt.p........pppptstppRptplh-SIclIApA.hhpcpC-lSEGslRltsLh-hlshs.p...tspYsuhhplYchlcchPpt-sR+pLsKpcRh+hDhpR.phEschcctIhp-sppL	.............IluLuuYAsaLLhpL++Qpt.p........pptphAhppRpspIh-SlpllspA.hl.psQC-LSEusIRlhsLh-hlttptp........tppYPAhhcLYclV+cMPpt-s.RppLsKpERM+.-Lp.RppAEucLpcsIhtElptL.............	1	15	35	59
+10508	PF10676	gerPA		Spore germination protein gerPA/gerPF	Mistry J	anon	PRODOM	Family	This is a bacterial family of proteins that are required for the formation of functionally normal spores.  Proteins in this family may be involved in establishing normal coat structure and/or permeability which could control the access of germinants to their receptor.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.37	0.72	-4.13	32	769	2009-01-15 18:05:59	2008-06-02 11:22:48	4	1	146	0	83	320	2	70.30	37	91.63	CHANGED	MPuhl...uslpIpslsusGslslGDshtISPpussKohuGuGuhNsGDhl....h.NhhshTsshDsDlsDQs.htNs	......MPuhV...sslhIpN..ssGshslGDsasloPhssoKuasGuGusNsG.hls...shstlSsTsshDsDlsDQs.hhs.s....................	0	17	45	53
+10509	PF10677	DUF2490		Protein of unknown function (DUF2490)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins. They appear to belong to the outer membrane beta barrel superfamily.	29.80	29.80	29.80	33.60	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.78	0.71	-11.19	0.71	-5.03	62	262	2012-10-03 17:14:37	2008-06-02 12:42:47	4	1	180	0	128	283	185	196.50	20	83.77	CHANGED	chssWhphthptpl...s......pchthph-hphRhtcs.............hs.chpphhlRsulsYpl.ssphplsh...GYsahhsps.tt.............thsEpRhapphhhphs..htphplspRhRhEpRahpt..........................ssphphRhR.plphphPlspptht......hhhhsElFhsl........stpsaspsRhhs.Glsaplspp..hplphGYhtp.......ttsspspchlth	.............................................................thWhpht.hptcls.........pchphth-hphR...htss.............hs.phpphhl+sulsYpl.ssphplth.......GY...sahhsp.hts.....................ptEpRhatphp.hphp..hs...ph.....pls..pRhRhEpRahtt..........................................ssch.phRhR.tlphshsl.spphht.......hhh.sElFhsh........t.hsppthcpsRhhs.Glsaplspp...hpl-lGYhtQh.pt...ttss...p....h.........................	0	66	112	122
+10510	PF10678	DUF2492		Protein of unknown function (DUF2492)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins.	19.70	19.70	20.90	20.90	18.50	16.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.50	0.72	-3.90	22	608	2009-01-15 18:05:59	2008-06-02 12:58:25	4	2	593	0	55	219	6	75.70	69	97.41	CHANGED	hsSlHGHpVhplMltpspsho+tpLpphltpcFGppARFHTCSApshsA-pLlpFLhpKGKhl.scpGhsssts+lCp	.....MDSIHGHEVLNMMIESGEQY.THuSLEAAIK.....A...RFGEpARF.HTCSAEsMTAuELVAFLAAKGKFI.s.s.E.-.GFSTcpSKICR...............	0	8	20	36
+10511	PF10679	DUF2491		Protein of unknown function (DUF2491)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	33.50	33.40	20.80	18.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.16	0.70	-11.18	0.70	-5.33	16	485	2009-01-15 18:05:59	2008-06-02 13:05:10	4	2	472	0	38	197	8	212.60	70	97.47	CHANGED	M.......FpchFG.+csps..ssPps.........P..hGLtlGtulplDsLthc..LLsschtltls.sssphItAhGcVcLspuspLhRaYsDD-sal.QVlssGs.stsclcDlpLahaa-otsluucu-apchlts..plutspYch-Gh.papRhWsssts..pscsVshsEclhptsss...spclpQhsMLYtRplst.spcEhLLlssEEc.....pps-hslshulGlsLpssDlpl	.........................h....FQRLFG..KcsKP..AlsRG................P........LGLHLNuGFTLDTLAFR..LLE-.pLLlALP..GE-..a.....TVAAVS+IDLG..GGSQIFRYYTS........G..DEFL.QINTTGGpDlDDIDDIKLFVYEESaGIocEsHWR-AIs.s......ps.....hGAM.TLN..W.....Q......E.K...RWQRFFNSEEP.GNIEPVYMLEKVENQscA...KW-VHNFTMGYQRQVT-....D....saEYLLLNGEESFN-.hGEPEWlFSRALGVDIPLTSLcI.........	0	9	17	24
+10512	PF10680	RRN9		RNA polymerase I specific transcription initiation factor	Wood V, Coggill P	anon	Pfam-B_44021 (release 22.0)	Domain	Initiation of transcription of ribosomal DNA (rDNA) in yeast involves an interaction of upstream activation factor (UAF) with the upstream element of the promoter, to form a stable UAF-template complex. UAF, together with the TATA-binding transcription initiation factor protein TBP, then recruits an essential core factor to the promoter, to form a stable preinitiation complex [1]. This Rrn9 domain, which seems to be constrained to fungi, is the two highly conserved regions of proteins which form one of the subunits of UAF and appears to be the region responsible for the interaction with TBP. The family includes the S.pombe Arc1 protein, Swiss:Q10204, which is found to be essential for the accumulation of condensin at kinetochores [2].	25.00	25.00	31.70	29.40	23.30	22.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-10.06	0.72	-4.24	22	106	2009-01-15 18:05:59	2008-06-04 12:54:52	4	4	105	0	80	106	0	72.80	33	14.00	CHANGED	L-sLc...tcDLulHLYsuahL+ph...A...ttp.hp.s.........................................sthhPp+pWouWPh.sspVP.sspphh....D	......L-sLc...ppDLulHLYsAahLK+t................ttp..p.s.................................................sthhPp+pWTAWPhs.sscVPtsspph.p............................	0	11	36	65
+10513	PF10681	Rot1		Chaperone for protein-folding within the ER, fungal	Wood V, Coggill P	anon	Pfam-B_27706 (release 22.0)	Family	This conserved fungal family is an essential molecular chaperone in the endoplasmic reticulum. Molecular chaperones transiently interact with unfolded proteins to inhibit their self-aggregation and to support their folding and/or assembly. Rot1 is a general chaperone with some substrate specificity, its substrates being the structurally unrelated Kre5 Kre6 Big1 Atg22, which are type I, type II, and polytopic membrane proteins. The dependencies of each for Rot1 do not share similarities. However, their folding does require BiP, and one of these proteins was simultaneously associated with both Rot1 and BiP. In addition, Rot1 may cooperate with BiP/Kar2 in the folding of Kre6 [1].	23.20	23.20	23.20	36.10	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.53	0.70	-4.99	28	127	2009-01-15 18:05:59	2008-06-04 13:13:12	4	3	108	0	89	128	0	202.10	44	86.02	CHANGED	LhGTWSoKSspVhTGPGFYDPls-hLlEPsLsGISYSFTcDGaaEEAhYRssuNPpsPsCPpuhlhaQHGoYplp.sNGoLhLsPhtVDGRQLlSDPCsss.....hus...YoRYsQsEpFppapV.lDs.Ya.Ghh+LpLapF.DGoPhpPhYLsY+PPhMLPTpTL..NPostst........................tpcthR...........phhcpshps.tpp......shhpp...thh..sthaWhulhhhuhGuhshh	..........LhGTWooKSppVhTGP...G.........FYDPlc-hhlEPshsGISYSF....TcDG.aaEEAhYpshuNPpsPsCspuhhhaQHGoYplp.sNGoLhLsP..htsDGRQLlSDPCssp.........tup........YoRYsQs.EhF.........ppap.Vhl......Ds....Y.......H...uhhpLpLap.a..DGo.PhpPhYLsY+PP.MLPTpoLNPsspst........................ttp..t.hR.................phhppp.h.t...hpp......shhtp....t..p.shhWahuhhhhuhGuhhhh...................................	0	27	48	76
+10514	PF10682	UL40		Glycoprotein of human cytomegalovirus HHV-5	Mistry J, Coggill P	anon	PRODOM_PD113623	Family	This is glycoprotein UL40 from human cytomegalovirus or herpesvirus 5. The signal sequence of the UL40 polypeptide contains an HLA-E ligand identical with HLA-Cw*0304. The first 37 residues of UL40, including this ligand, are predicted to encode a signal peptide.  The virus thus prevents the lysis by NK (natural killer) cells of the cell it has invaded [1-2].	25.00	25.00	38.00	27.60	20.60	19.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.75	0.70	-4.83	2	171	2009-01-15 18:05:59	2008-06-04 14:21:54	4	1	6	3	0	168	0	212.50	94	96.35	CHANGED	hRhtFhhssMAP+TLll...llhhtl.u.hs..ApTssTTsGAhhupsP+.....C.hVFpGWVYAhYHpGsMsLMTlDV.CCR.pssNo........tcspLLI-VGNpTRpt....oCpsH..u.Q.tDC.sphVHVpGlspStFhLopLpSCCLNp.SpLSE+VAYHL+hRPAsFGLETWAMYTlGlLuLGSFSSFYsQlh+sL....psaHYAhKt	......................................TRIGFTCAVMAPRTLILTlGLLCMRIRSLLCSPAETTVTTAGshSAHGPh.....CPLVFQGWAYAVYHQGDMALMTLDVYCCRQTSSNTVVAFSHHPADNTLLIEVGNNTRRHVDGISCQDHFRA.QHQDCPAQTVHVRGVNESAFGLTHLQSCCLNEHSQLSERVAYHLKLRPA.TFGLETWAMYTVGILALGSFSSFYSQIARSLGVLPNDHHYALKK........	0	0	0	0
+10515	PF10683	DBD_Tnp_Hermes	Hermes_DBD;	Hermes transposase DNA-binding domain  	Bateman A	anon	PDB:2bw3	Domain	This domain confers specific DNA-binding on Hermes transposase [1].	20.50	20.50	20.70	23.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.29	0.72	-4.51	4	22	2009-01-15 18:05:59	2008-06-04 16:21:41	4	5	13	2	13	19	0	61.90	36	13.87	CHANGED	pspEL+hVStpDKcEAIEKCTQWVVcDCpPFSAVoGuGFhchVKFFlKIGA.YGEpVDV-DLLPsPsT	............................pKpchhc+ssp....aslpDhRPFshVpGpGFhcLsphhlplGApYGppVsl-slLPpP.T.....	0	1	7	11
+10516	PF10684	BDM		Putative biofilm-dependent modulation protein	Mistry J, Coggill P	anon	PRODOM_PD064586	Family	This is a family of tightly conserved proteins from Enterobacteriaceae which are annotated as being biofilm-dependent modulation protein homologues.	27.40	27.40	27.40	90.60	27.00	27.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.12	0.72	-3.76	2	398	2009-09-11 08:44:46	2008-06-04 16:56:56	4	1	396	0	9	28	0	71.60	95	100.00	CHANGED	MCFINLRSVADTINTQTRRITMFTYYQAENSTAEPALVNAIEQGLRAEHGVVTEDDILMELTKWVEASDNDILSDIYQQTINYVVSGQHPTL	.....................MFTYYQAENSTAEPALVNAIEQGLRAEHGVVTEDDILMELTKWVEASDNDILSDIYQQTINYVVSGQHPTL..	0	2	2	5
+10517	PF10685	KGG		Stress-induced bacterial acidophilic repeat motif	Mistry J, Coggill P	anon	PRODOM_PD027049	Family	This repeat is found in proteins which are expressed under conditions of stress in bacteria. The repeat contains a highly conserved, characteristic sequence motif,KGG, that is also recognised by plants and lower eukaryotes and repeated in their LEA (late embryogenesis abundant) family of proteins, thereby rendering those proteins bacteriostatic. An example of such an LEA family is LEA_5, Pfam:PF00477. Further downstream from this motif is a Walker A, nucleotide binding, motif GXXXXGK(S,T), that in YciG of E coli, eg Swiss:Q8X7B4, is QSGGNKSGKS [URL]. YciG is expressed as part of a three-gene operon, yciGFE, and this operon is induced by stress and is regulated by RpoS, which controls the general stress-response in E coli. YciG was shown to be important for stationary-phase resistance to thermal stress and in particular to acid stress.	20.40	20.40	20.50	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.29	0.72	-6.39	0.72	-3.93	45	2185	2012-10-01 20:07:30	2008-06-05 11:36:42	4	12	679	0	402	1036	15	21.90	59	59.07	CHANGED	sFAs.Dt-+tpEhupKGGcuSsu	......NFtp.D.c+A...SEAG+KGGQpSsG.....	0	82	192	315
+10518	PF10686	DUF2493		Protein of unknown function (DUF2493)	Mistry J, Coggill P	anon	PRODOM_PD031789	Family	Members of this family are all Proteobacteria. The function is not known.	24.50	24.50	24.60	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.43	0.72	-4.43	34	308	2009-01-15 18:05:59	2008-06-05 14:06:06	4	3	207	0	113	326	118	70.40	36	28.33	CHANGED	PpGs+lAFoGGtDap...Daph........IWssLDcl+A+h.....PDMl..LlHGGss+GAEpIAApWAcsR..sVsQlsF+PDWp+HG	.............................Gs+lhloGGt-.as...Dpch....................last.L.D.p....l+s+t.....P-.hl...LlHG.....Gu..+GA-tIAupWA...cpR.....t..Vsp..l..s...FpsDWpc+............	0	22	74	95
+10520	PF10688	Imp-YgjV		Bacterial inner membrane protein	Mistry J, Coggill P	anon	PRODOM	Family	This is a family of inner membrane proteins. Many of the members are YgjV protein.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.74	0.71	-4.81	34	708	2009-09-11 16:42:10	2008-06-05 17:27:52	4	3	624	0	127	358	26	145.00	42	89.78	CHANGED	thhhuQhlGhlAhslslhuF.pKpcc+lhhhlhstsllhulHFhLLGuhsAAshhhluulRhhhulhspS.........phlhhhFlslsllh...shhshpshhsllslhGolluThAhFphcGlp.hRhhhlluossWlhpNlllGShGGsLhEshhlssNhlslYR...happptps	....................ahlAQulGsl.AFhlGIosFas+--+Rh+hpLslausllulHFhLLGshsAuhoslLsulRoh.l.o....l+Tc.S.........hhVMs.lFIlL...ohsh..............Gl.sph....p.c.l.ELLPllGTlluTaALFpscGls.hRs.V.MhhuTsCWVIHNhahGSIGGohlEuoFllhNulsIlRaaRhpppu.................	0	23	55	90
+10521	PF10689	DUF2496		Protein of unknown function (DUF2496)	Mistry J, Coggill P	anon	PRODOM_PD581819	Family	This family consists of proteins from Gammaproteobacteria spp. Many members are annotated as being like the E coli protein YbaM.	25.00	25.00	40.00	39.90	18.50	15.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.73	0.72	-4.37	25	670	2009-01-15 18:05:59	2008-06-06 09:53:35	4	1	667	0	66	195	1	43.90	73	79.54	CHANGED	sL-sAP-ElKLAVDLIhLLEsN-I-PpsALuAL-IVppDappKL	..SLENAPD-VKLAVDLIVLLEENpIPAcTVLRAL-IVKRDYEpKL.	0	4	17	43
+10522	PF10690	Myticin-prepro		Myticin pre-proprotein from the mussel	Mistry J, Coggill P	anon	PRODOM_PD189357	Family	Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis, the Mediterranean mussel. Some isoforms show antibacterial activity against gram-positive bacteria, while others are additionally active against the fungus Fusarium oxysporum and a gram-negative bacterium, Escherichia coli D31.  Myticin-prepro is the precursor peptide. The mature molecule, named myticin, consists of 40 residues, with four intramolecular disulfide bridges and a cysteine array in the primary structure different from that of previously characterised cysteine-rich antimicrobial peptides. The first 20 amino acids are a putative signal peptide, and the antimicrobial peptide sequence is a 36-residue C-terminal extension. Such a structure suggests that myticins are synthesised as prepro-proteins that are then processed by various proteolytic events before storage in the haemocytes as the active peptide. Myticin precursors are expressed mainly in the haemocytes. The family Mytilin has been merged into this family.	28.50	28.50	28.60	39.60	25.70	28.40	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.82	0.72	-3.96	5	179	2009-01-15 18:05:59	2008-06-06 09:56:07	4	1	5	1	0	179	0	98.50	78	99.26	CHANGED	MKATILLAVlVAVlVAVpEAcuhuCTSYaCuKFCGoAuCoaYlChlLHsGKhCtCLHCSRs+.PhthotcA+shNEt...hDhoPpMN-MENLDpGMDM...........l	MKATILLAVVVAVIVGVQEAQSlsCTSYYCSKFCGSAGCSLYGCYhLHPGKICYCLHCpRAESPLALSGSARNVN-pNpEMDNSPlMNEhENLDQEMDMF..	0	0	0	0
+10523	PF10691	DUF2497		Protein of unknown function (DUF2497) 	Mistry J, Coggill P	anon	PRODOM_PD475087	Family	Members of this family belong to the Alphaproteobacteria. The function of the family is not known.	20.90	20.90	21.80	29.30	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.48	0.72	-4.01	43	281	2009-01-15 18:05:59	2008-06-06 10:13:57	4	1	277	0	96	223	45	73.60	40	34.00	CHANGED	pcsLlStssspssssshpsLupslp............ssp..tpTlE-lVc-hLRPMLp-WLDpNLPslVEclVcpEIcRls+p	.........................................................................................................................sllSptotpplusuFpsLscslp.............ss..tppolE-lstEhLRPhLpsWLDcNLPsLVE+lV+cEI-Rls+.s...	0	29	54	67
+10524	PF10692	DUF2498		Protein of unknown function (DUF2498)	Mistry J, Coggill P	anon	PRODOM_PD060534	Family	Members of this family are Gammaproteobacteria. Many are annotated as like E coli protein YciN. The function is not known.	25.00	25.00	26.00	26.00	17.90	16.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.58	0.72	-4.37	12	633	2009-01-15 18:05:59	2008-06-06 10:33:02	4	1	631	2	51	152	1	81.20	75	98.44	CHANGED	pspppPIscpsLLh.ANplI+-HEDYlpGMcATsVEQKssVLVF+GEaFLDEpGLPTsKTTAVFNMFKaLAHhLStKYpLhc	....p.KETQPIDRETLLtEANKIIREHEDTLAGIcATGVTQRNGVLVFoGDYFLDEQGLPTsKSTAVFNMFKHLAHVLSEKYHLVD.................	0	4	14	32
+10525	PF10693	DUF2499		Protein of unknown function (DUF2499)	Mistry J, Coggill P	anon	PRODOM_PD077121	Family	Members of this family are found in plants, lower eukaryotes, and bacteria and the chloroplast where it is annotated as Ycf49 or Ycf49-like.  The function is not known though several members are annotated as putative membrane proteins.	22.10	22.10	24.50	23.70	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.36	0.72	-3.94	39	145	2009-01-15 18:05:59	2008-06-06 11:16:05	4	4	121	0	85	138	93	85.40	48	53.36	CHANGED	sLSlsTWhIHluSllEWhlAIhllhcau..phptppshphLulAMlPsLlSAhsAhTWHhFDNs.sLthLVsLQAhhTllGN..hsLshAAapl	..........ALSlPTWhIHlSSVlEWlhAhhLlapYu..phsspptW+tLuhuMlPtLsuAhCACTWHhFsNs..uLphLVsLQAshTllGN..hTLshAAah..........	0	27	54	76
+10526	PF10694	DUF2500		Protein of unknown function (DUF2500)	Mistry J, Coggill P	anon	PRODOM_PD076478	Family	The members of this family are largely confined to the Gammaproteobacteria. The function is not known.	22.00	22.00	22.00	22.00	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.27	0.72	-4.06	28	788	2009-09-11 12:25:21	2008-06-06 11:50:33	4	3	759	21	73	338	5	111.30	46	90.70	CHANGED	PlhhhllhhlllshhsFhah......phhpcatpspsAPhhslpspllsK+ppshscspspp............psp....cYalpFchpsGs...................+hEFpV.usc.YptLs.GDpGpLTaQGs+FlpFsh	.............................................PLFFIllluLI.lVAAo.F+Fh......QQRRE+AsN-hAPlppc.VsVosKRE+slsDRRSRQpEV.ssA......uooh....RYEsoF+Pp.sGG...................EpsFRL..suppYHALssGD+GTLoY+GTRFluF..s.........................	0	17	33	49
+10528	PF10696	DUF2501		Protein of unknown function (DUF2501)	Mistry J, Coggill P	anon	PRODOM_PD096667	Family	Members of this family are all Proteobacteria. Several are annotated as being YjjA or YjjA-like, but this protein is uncharacterised.	19.80	19.80	19.80	23.00	19.30	19.60	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.54	0.72	-4.00	19	613	2009-01-15 18:05:59	2008-06-06 13:05:51	4	1	595	0	55	226	8	79.70	64	49.43	CHANGED	KNNhLu.u.ssAssVKspLhuKLGhsstp.tspDssYtsGlpGlLssusGpplsLs..Gs.sLppplKpKACDhVLpQGpu..Lh	.............KQKLAS...s..TssENIKNQlLpKLGLsopE.QccDTNYL-GlQGLLKTKDGQQLNLsN.....IGoTPLAEKVKTKACDLVLKQGLN.h.h....	1	4	20	38
+10529	PF10697	DUF2502		Protein of unknown function (DUF2502)	Mistry J, Coggill P	anon	PRODOM_PD029719	Family	Members of this family are all Gammaproteobacteria. The function is not known.	20.60	20.60	29.10	23.20	18.00	18.20	hmmbuild  --amino -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.13	0.72	-3.88	13	798	2009-01-15 18:05:59	2008-06-06 13:44:39	4	2	515	0	54	211	7	83.10	63	77.09	CHANGED	pIsL.l.......PuVpLQIGDRDpRGpYWDGhcWRDcsWW+pH............YpWcGsRWpc+ssttcpta.+cp...................chDc+p........s+Gss++H	............EITL.LPSIKLQIGDRDchGNYWDGGHWRD+caW+p+....................YEWRtNRWa+H-s..s..h.+.+.s.a.cK+pt...............thccRDDHR...G+GtG+tH..............................................................	0	3	13	30
+10530	PF10698	DUF2505		Protein of unknown function (DUF2505)	Mistry J, Coggill P	anon	PRODOM_PD099734	Family	Members of this family are all Actinobacteria. The function is not known.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.53	0.71	-4.73	34	427	2012-10-02 19:24:03	2008-06-06 16:13:37	4	2	348	0	112	314	13	158.00	27	92.63	CHANGED	h-hsspas.ssl-pVapshsccsYaps+hpphus...tsplsphsssusG.....hplshpp..sl.sc.pLPuhlpphhssclplpcpEpW.ssht..supspuphpsslsGsPsslsGshtLps......susuophplsuslcVcVPLlGGKlEphluspltchlssEpchsppWl	...................................................................p.sspas.sss-pVhthhsctsa...Wpshh.p.phus....splp..s.hss...s...s..cu.......lplshtp....hlssp.....L..Puhl..pp.hls.u...s.Lplc..pspoW..ss..hs..sus...tpuo...ls...ss..lt.....GsPsphsGptslps................susG.oclphsuslpVpl......P.....llG...uKlEphhusplsphhshEpchsspWl...............................	0	35	81	103
+10531	PF10699	HAP2-GCS1		Male gamete fusion factor	Bateman A, Coggill P	anon	Billker O	Domain	The gene encoding Arabidopsis HAP2 is allelic with GCS1 (Generative cell-specific protein 1). HAP2 is expressed only in the haploid sperm and is required for efficient guidance of the pollen tube to the ovules. In Arabidopsis the protein is a predicted membrane protein with an N-terminal secretion signal, a single transmembrane domain and a C-terminal histidine-rich domain [1]. HAP2-GCS1 is found from plants to lower eukaryotes and is necessary for the fusion of the gametes in fertilisation. It is involved in a novel mechanism for gamete fusion where a first species-specific protein binds male and female gamete membranes together after which a second, broadly conserved protein, either directly or indirectly, causes fusion of the two membranes together. The broadly conserved protein is represented by this HAP2-GCS1 domain, conserved from plants to lower eukaryotes [2]. In Plasmodium berghei the protein is expressed only in male gametocytes and gametes, having a male-specific function during the interaction with female gametes, and being indispensable for parasite fertilisation. The gene in plants and eukaryotes might well have originated from acquisition of plastids from red algae [3].	19.70	19.70	20.20	26.60	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.41	0.72	-4.00	22	100	2009-01-15 18:05:59	2008-06-07 15:35:39	4	1	68	0	69	107	1	48.30	38	6.85	CHANGED	hllspshhshsGt...pCsKIGVShpsapsp.s...sh.Cst..GoCLpsQLtcaap	..........hlLs+shhslsGh...-CsKIGVSapuFpsQ.s...sh.Cst.huoCLpsQLtcah......	1	30	46	62
+10534	PF10702	DUF2507		Protein of unknown function (DUF2507)	Mistry J, Coggill P	anon	PRODOM_PD089657	Family	This family is conserved in Firmicutes. The function is not known.	30.00	30.00	30.80	30.10	29.60	29.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.66	0.71	-4.48	22	327	2009-01-15 18:05:59	2008-06-09 15:33:57	4	2	325	2	57	203	0	123.60	42	79.59	CHANGED	ssFuhpLlR-hlLPslLGp-psslLYWAGKcLAR+aPlpohE-l.tFFppAuaGsLplhKpK+pphhFpLoGshlspRlpp..ppssFpLEAGFlAEplppppthssEuh..thp++..pppVhlpVph	...............shFuhpLlR-hLLP-lLGsDtssILYWAGKcLARKaPLpohE-lhpFFcpAuaGsLollccK+pchpapLpGsllspRhcp..p.ccssFpLEAGFIAEplQpQpshssEuh.tphc++..p.c.pVphhVp......................	0	16	34	44
+10535	PF10703	MoaF		Molybdenum cofactor biosynthesis protein F	Mistry J, Coggill P	anon	PRODOM_PD122919	Family	MoaF protein is essential for the production of the monoamine-inducible 30kDa protein in Klebsiella [1]. It is necessary for reconstituting organoautotrophic growth in Ralstonia eutropha [2]. It is conserved in Proteobacteria and some lower eukaryotes. The operon regulating the Moa genes is responsible for molybdenum cofactor biosynthesis.	22.40	22.40	22.70	22.60	19.20	22.30	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.64	0.70	-5.32	12	151	2009-01-15 18:05:59	2008-06-09 16:14:14	4	2	115	0	36	122	6	252.70	41	92.97	CHANGED	sssstaIsVGALA-GFA.csplLsssssLuG+shsLphssGtshtpthssp........psLpWpthttt.................GpusYRAoplRsulYaVDalc.tpspt.SVSLVlDhpptphouVhGpLPsc..Atsp.sshsRshpsh.LTuVcspFhaGslss.htsus..huPTc-LIGhRshYpYSPoEsYEHIYLNssaYsWQCLpGsE+GLADsDRC+haKlA-pLYLFVWREKllPTLGVllIDLp...thRoDGKIFGYpsuDFushsNFslGAaupVLNpTpH	....................................................s.pssalpVGALA-GF..-sphLsssssLsG+slslt.....hssG..thh.ph.t.F..ss........psLpWcttpss.................GpssY+AoplRsslaFVDal.........c.sptss.olSLVlDhsptshouVhGplPsc..st.chsuhsRVtpsh.lTuVpstFhaGslss.h.tsus...u.Tc-LIGpRshYpYS..PoEsYEHIYLNssaYsWpCLsGsE+GLAD.V.......DRC+haKlA-sLYLFsWREKl.l.PTLGVllIDLp...ttRocGKlhGYpsuDhusluNFPlGAauplLNpTha.......................	0	3	10	23
+10536	PF10704	DUF2508		Protein of unknown function (DUF2508)	Mistry J, Coggill P	anon	PRODOM_PD057080	Family	This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	20.40	20.40	20.50	20.90	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.30	0.72	-3.80	23	434	2009-01-15 18:05:59	2008-06-09 16:57:29	4	1	431	0	88	236	2	72.40	30	89.37	CHANGED	M......Fh++K....scl++....-hD-cLlphlpcs+ccappp+pl.ppoh-..ss.p-lhhptKlscAKYhFLh+EA+pRplphp	.............................................hhp+p.....cl+c.........p.hD.....p.c..Llphlccs+pchppt.+phhcps..h-....s..pps...lhph+lAcAKYhaLh+EA+pRtl+h.p......	0	36	65	75
+10537	PF10705	Ycf15		Chloroplast protein precursor Ycf15 putative	Mistry J, Coggill P	anon	PRODOM_PD014917	Family	In some species of plants the ycf15 gene is probably not a protein-coding gene because the protein in these species has premature stop codons. Most of the members of the family are hypothetical or uncharacterised [1].	25.00	25.00	25.60	39.40	21.10	18.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.25	0.72	-3.93	3	64	2009-01-15 18:05:59	2008-06-09 17:56:30	4	1	62	0	4	51	0	72.20	68	98.05	CHANGED	ETLVSSIFWTLAPWNNMLLLKHGRIEILDQNTMYGWYELPKQEFLNSEQPEPITHYIKKFPLMKcIGPpcpp+..htphSchlllotssoNHahN	.....................M..LLL..KHGRIEILDQNTMY..GWYELPKQEFLNSEQP..IhTT.KKa.lhhclsP.cppK..h...................t............	0	1	3	3
+10538	PF10706	Aminoglyc_resit		Aminoglycoside-2''-adenylyltransferase	Mistry J, Coggill P	anon	PRODOM_PD012767	Family	This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin [1]. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.02	0.71	-4.65	3	186	2012-10-02 22:47:23	2008-06-09 17:57:47	4	1	128	4	26	138	5	140.20	38	79.89	CHANGED	MNcLHIsLIHpIFAAADclNLPLWIGGGWAIDARLGRITREHDDIDLTFPGDR+AEFEsLlcthGGpITEQTDYGFLAplQGlLLDCEPAaasD-AYEIE-sPPGSCPhssEGVIuG+PVRCNSWEAILWDYFYYtDEVPpu-WPsKHlaSasLAC-SLG-ssVcsLRcQF+oR	............................llshh-ctslshWlsGGWulDAhLG+.TRcHcDIDlsFsuc+ps.cl..sllc.h.G....h..+.l......c...h..s...hh..ltc.t...th..lDhcPh.hss-.u...htts.st.u.u...p...........t.....p....s.hts+.l.C.s............................................................................................................................................................	0	7	19	24
+10539	PF10707	YrbL-PhoP_reg		PhoP regulatory network protein YrbL	Mistry J, Coggill P	anon	PRODOM_PD110862	Family	This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-10.95	0.71	-4.98	22	504	2012-10-02 22:05:25	2008-06-10 11:39:02	4	2	480	0	35	279	172	183.00	67	87.86	CHANGED	lpLpppp.lupGspRhsYtHPtcssphlKVhpspt...................tsth+phtpElptYhplph.......+pth.hshls+haGhlpTshGhGhlh-hltDhsGshu.TLpphh...cpsthss.thtptLcphhphlh-scIlsp.-lpspNIVhtcpspup.....phhllDGhGstph...lPltshuphhs++plp+phc+hhpcht	.............................................................I+LSEQoPLGTGRHRKCYAH...PED...A...p...RC..IKIVY+Ru...........................-.G.G.DKE.IRRE.LKYY.AHLu........RRLcDWSuIPRYHG..TVETDCGT..GYVYDlIs....DF..D.G....K.PS.ITLT.EFAt....QCRY.E..E.D...lA.....p....LRQ...LL....K....pL...KRYL....pDN+IVTM.S.LKPQN..ILC+RISESE....VlPVVCD.N...IGESTL....IPLATWS.KWCChRKpERlW+RFIAQP.A................................................	0	11	18	27
+10540	PF10708	DUF2510		Protein of unknown function (DUF2510)	Mistry J, Coggill P	anon	PRODOM_PD056443	Family	This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	20.90	20.90	20.90	20.90	20.30	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.26	0.72	-4.49	31	349	2009-01-15 18:05:59	2008-06-10 13:08:27	4	19	198	0	127	284	30	37.80	43	13.84	CHANGED	sGWYPDPus....sp........phRaWDGppWTsph...pPh...Pussstss	..sGWYPDPsG....ss........thRaWDGspWTcps.............pPs.....st......t.......................................	1	48	96	123
+10541	PF10709	DUF2511		Protein of unknown function (DUF2511)	Mistry J, Coggill P	anon	PRODOM_PD064657	Family	This family is conserved in bacteria. The function is not known.	20.40	20.40	21.10	20.80	19.70	17.00	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.07	0.72	-3.64	14	641	2009-01-15 18:05:59	2008-06-10 13:21:12	4	2	562	0	53	212	2	86.40	68	76.30	CHANGED	slo+hcaGc.cWsFopEEVtLpC+sGsAL.ashNsuT.hpYPLN-lAppphct.Gp..upsIssIhlDDPs....pPG...................pKhS.LsPal-cA.pLC	.........TVSRFEVGKDKWAFNREEVMLTC..R....P......G...........N......A....L...YV..IN..PSTLVQYPLNDIApppVAo.GKTcAQPIuVIQIDDPs.....sPG.......................EKMS.LAPFIERApKLC..........................	0	7	16	31
+10542	PF10710	DUF2512		Protein of unknown function (DUF2512)	Mistry J, Coggill P	anon	PRODOM_PD032002	Family	Proteins in this family are predicted to be integral membrane proteins, and many of them are annotated as being YndM protein. They are all found in Firmicutes. The true function is not known.	23.70	23.70	23.90	25.00	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.93	0.71	-4.71	20	314	2009-01-15 18:05:59	2008-06-10 13:55:09	4	1	198	0	59	209	0	127.60	34	92.27	CHANGED	M+..HltALslKalhshslLhllLshhassoFscllhlollLolloYhlGDLalLPR......huNhsAoluDFGLualllWlhuhhhhs..sshsluhuollSAllluluEhFFHtYhhcplls.....p.tp.....phpapTEhu-E	.....................Mp.HhhsLllKhhhhhhllhlh...Lsl.hhs..ho.hspllhholhlohsuYhlGDhhILs+........hGNhsAohuDhsLualslWlhs.hhhs..sshpIuhuu.l.l.uA.l.llul.uEhaFHtahpppshp.....p.pt.t.....t.tathEhu-E..............	0	21	44	49
+10543	PF10711	DUF2513		Hypothetical protein (DUF2513)	Mistry J, Coggill P	anon	PRODOM_PD457411	Family	This family is found in bacteria. The function is not known.	29.40	29.40	29.40	31.40	29.00	29.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.39	0.72	-3.94	27	250	2009-01-15 18:05:59	2008-06-10 14:04:32	4	2	231	0	43	168	3	102.10	31	83.09	CHANGED	KhDh-llRclLLplEst.h...............tt.thstasp-..pl.YHlthL..p-AGllpuphpth............st..........hltpLTasGH-FLDslRcsslWpcsK.phtppsu...uhol	....................................KhshDhlRclLLclEsptphspsl...................pshth.spash-......slhYplthL..p-Ashlssp.htht................st.hh.h........hlpclTasGH-FLDsIR-spsWpcsK.phtsKsssho................	0	14	25	36
+10544	PF10712	NAD-GH		NAD-specific glutamate dehydrogenase	Mistry J, Coggill P	anon	PRODOM_PD017095	Family	The members of this are annotated as being NAD-specific glutamate dehydrogenase encoded in antisense gene pair with DnaK-J [1].	19.10	19.10	27.00	26.90	18.80	18.50	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.41	0.70	-6.24	21	144	2009-01-15 18:05:59	2008-06-10 16:57:01	4	3	117	0	30	146	1412	408.70	35	78.00	CHANGED	hsLptshptscsthDthhshshcLVAhlhpcLL.........GtVcpsluLVhuhcpLssLLVhhGVthGlLcHhlDlhlspsstuL.DtDLLhLsGuLVLGtcVcDAVGVDVEGchDLRHuARstRsshpVELs-cLVVtpHhsLsLEcsDtHutLVVhsGtEcLsLLGRDpuVAlDQsG-Hssp+hDAcRQRuHVEQQHVLcV.....ALQssuLDsuAcucsFVRVcshVRLLA.EElhHhhhDLtHsGhsADpcclVDlsttpAuVLpptLsRL-psL-plhcpuFpLGAuphcscV..LcstsltpDctpVDhGLhttRphDLtLhspFLpsLQsphVlsQVDullhLELsspVVD-spVEVFTAcEtVAVGshHFEpA....lsDhpDGcVEusAAcVlDRDthshh..LVcslGpRupGRLVDDspchcsuDhAGVLGsLTLuVVEVuRpGDDpltchhApluhGuFLHLhQccstcLtRplhLA....hphDPsVAlsulsDh.tpphhVLhphtVscusADQALctcpGVhRVtcsLsLuRLscpshsllscscDRRtGutAFsVhDchplsAl.HDucAuVGsscVDTssFsH	.........................................hp..hph.pthhs....hh.hphlu..h.....hhphhh..........tthpphhtLlhthtthhthhVhhulhhslhpHhhshhhhpsttsl.cuDllhhsuhhlhttplpDsVulDlEuphDLRpsu+pthss.plEhspphVlttph.shsLpch-t.ttLlVhtttEtLthhutDttVhhDphtccss.........tthsspt...pttpVpQp.lhtl.....shppssLpttspspshltVpshsthhs.cch.p.hhphhHsuhsspppphVsht.hpsslhpt.htthptshcplhtphhphtstph.hph..hts.t...tts.tplchGhhtttphshthhsthhp.sLptphlh..hplpshhhhchhtp.hDps.lplhssp.tlshut.phcth....hschpptplEtssspV.spc.hhh....h....lpsluptstuthVDDs.phpssshsulhGsL...sLtlV.cVst.tDstht.hhsplhhuthLchhpc.ttsLhtt.hLs......hphc.tlshh..tph.h..h.lhh.hhlh.hssspAhsttpushtVtctLshstlss.pshshht.ssctRtushshtlhpphthhsl..+st.stVutsplsss.ht.................................................	0	6	13	28
+10545	PF10713	DUF2509		Protein of unknown function (DUF2509) 	Mistry J, Coggill P	anon	PRODOM_PD077226	Family	This family is conserved in Proteobacteria. The function is not known but many of the members are annotated as protein YgdB.	25.00	25.00	26.00	25.80	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.98	0.71	-4.40	10	534	2009-09-10 15:07:53	2008-06-10 17:00:33	4	1	521	0	38	192	1	120.60	58	89.88	CHANGED	hLLlLG.LLLpGlppQLDuhhthsusEpptL+AastApSALsWGpuQsWutpst..........WpCpphsp.sh+uCLRhhSsuphlllcGput......slpLaQ.......pGssssssllhssHGW.DFCP.K-suhCp.hs	...................hLLlLGSLLLQGhsQQpcSaAuRVohESpuLRRQAlVQSALtWG.+.hpsWpspss....................hQCpp.Yu.....u.....osARVCLRlLu-sEslLlAGh-G.......VoLWR.........TGcV.I-GsI.VFSP+GWSDFCPLKEtALCQlP......	0	2	9	21
+10546	PF10714	LEA_6		Late embryogenesis abundant protein 18	Coggill P	anon	Covarrubias A	Family	This is a family of late embryogenesis-abundant proteins There is high accumulation of this protein in dry seeds, and in the roots of full-grown plants in response to dehydration and ABA (abscisic acid application) treatments [1]. This LEA protein disappears after germination. It accumulates in growing regions of well irrigated hypocotyls and meristems suggesting a role in seedling growth resumption on rehydration [2]. As a group the LEA proteins are highly hydrophilic, contain a high percentage of glycine residues, lack Cys and Trp residues and do not coagulate upon exposure to high temperature, and for these reasons are considered to be members of a group of proteins called hydrophilins [3]. Expression of the protein is negatively regulated during etiolating growth, particularly in roots, in contrast to its expression patterns during normal growth [4].	20.50	20.50	21.30	51.70	20.10	19.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.71	0.72	-4.17	6	28	2009-01-15 18:05:59	2008-06-10 17:33:36	4	2	14	0	17	26	0	80.70	48	71.36	CHANGED	SEcc..psp.-sLPhEsSPYscYcDLEDYKppGYGTpGHQEPKsG+GuGuTDAPT.SGu.hpucutsou....TDAtNp+usP	.........p.....ppscpptLPh-sSPYlpYcc...LEDYKh+uYGscGH.pPK.sG+GGGu.TDAPTlSGssh..........ucutsus.........sDAhNpps..................................	0	3	9	13
+10547	PF10715	REGB_T4		Endoribonuclease RegB T4-bacteriophage encoded	Mistry J, Coggill P	anon	PRODOM_PD091708	Family	The RegB endoribonuclease encoded by bacteriophage T4 is a unique sequence-specific nuclease that cleaves in the middle of GGAG or, in a few cases, GGAU tetranucleotides, preferentially those found in the Shine-Dalgarno regions of early phage mRNAs. Phage RB49 in addition to gpRegB utilises Escherichia coli endoribonuclease E for the degradation of its transcripts for gene regB. The deduced primary structure of RegB proteins of 32 phages studied is almost identical to that of T4, while the sequences of RegB encoded by phages RB69, TuIa and RB49 show substantial divergence from their T4 counterpart.	27.40	27.40	27.60	28.30	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.62	0.71	-4.10	14	136	2012-10-03 00:09:25	2008-06-11 13:56:22	4	1	74	1	0	99	0	142.10	24	90.69	CHANGED	Mp..........c.hphaphpatph.sphtchpcs.........tthsp.Ft...........lhap.p.hsp.h.+phctcashthhpplhspl...ph.t.huh...........cthphpsthh........ElpcGshhlulsssp.s.sh...tulththtlhsptph.tphshhhl	.....................p.t..h.hpp....c.hp.at.patph.sphtctscp........tslu.tFt...........lhappphhsc..sl...+..phccpashthFpclpspl..hph.....phluh...st....c....hlcshcapstph........Elp.....c....Gslhhu.h.osspss.ph...psuhphthsllpptph.tptphh................	0	0	0	0
+10548	PF10716	NdhL		NADH dehydrogenase transmembrane subunit	Mistry J, Coggill P	anon	PRODOM_PD026898	Family	The NdhL family is a component of the NDH-1L complex that is one of the proton-pumping NADH:ubiquinone oxidoreductases that catalyse the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. NDH-1L is essential for photoheterotrophic cell growth. NdhL appears to contain two transmembrane helices and it is necessary for the functioning of though not the correct assembly of the NDH-1 complex in Synechocystis 6803. The conservation between cyanobacteria and green plants suggests that chloroplast NDH-1 complexes contain related subunits [1].	25.00	25.00	53.50	53.50	22.20	21.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.02	0.72	-4.21	24	91	2009-09-10 15:53:21	2008-06-11 14:19:09	4	1	85	0	38	89	84	79.60	44	78.07	CHANGED	M..................................hhs.l..............psllVlhsYsuLuuhYLlVlPlhLahWhNpRWashuphERhhhYhLVFLFFPGhlLhAPFLNhR.psps.	.....................h..........h...............phhhlhlhYhsLushYLLVlPhhlahahppRWYhtuphERhhhYhLVFhFFPGllLhuPFLNFR.ps+p..	0	6	24	35
+10549	PF10717	ODV-E18		Occlusion-derived virus envelope protein ODV-E18	Mistry J, Coggill P	anon	PRODOM_PD579825	Family	This family of occlusion-derived viral envelope proteins are detected in viral-induced intranuclear microvesicles and are not detected in the plasma membrane, cytoplasmic membranes, or the nuclear envelope. The ODV-E18 protein is encoded by baculovirus late genes with transcription initiating from a TAAG motif. It exists as a dimer in the ODV envelope and contains a hydrophobic domain which is putatively acting as a target or retention signal for intranuclear microvesicles [1].	23.10	23.10	23.10	62.90	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.20	0.72	-4.54	18	56	2009-01-15 18:05:59	2008-06-11 16:54:42	4	1	53	0	0	50	2	83.90	47	99.70	CHANGED	MDshRss.......ssssth...phsslNPNhLMTILIsLVIIILLIhLFQ.SSsussSu....ssssptu..ahNPLNATMRsN.....PhV.NTsQRphL	....M-.hRss.......sssss..stplstlsPNhhMTILlsLVIIILLIlLFQSSSsussSu........s..s..........sssphuFhNPLNATMRsN.....PFV..NTsQRph..........	0	0	0	0
+10550	PF10718	Ycf34		Hypothetical chloroplast protein Ycf34	Mistry J, Coggill P	anon	PRODOM_PD019546	Family	This family is of proteins annotated as hypothetical chloroplast protein YCF34.  The function is not known.	25.00	25.00	44.20	44.10	16.40	15.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.81	0.72	-3.59	23	81	2009-01-15 18:05:59	2008-06-11 17:13:16	4	1	79	0	31	81	84	75.60	54	91.41	CHANGED	MCICVsCpaVDRCpTYHsVEpQHt.sHLopsPDFcPppPpIHVslh..s..ssthtlEWDVhuCpSFhp-.G+WsRLRP	.MCICVNCcaVDRC.TYHAVEpQHpp..s...HLo-...sPcF-Pp..p..PsIp.VNI+..........s.p....sstlchEWDVluCpSFhpEhGKWu+LRP.......................	0	8	22	30
+10551	PF10719	ComFB		Late competence development protein ComFB	Mistry J, Coggill P	anon	PRODOM_PD066657	Family	This family is conserved in bacteria. Some members, with three conserved cysteines, are annotated as late competence development protein ComFB.	25.00	25.00	28.70	28.60	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.71	0.72	-4.24	60	450	2009-01-15 18:05:59	2008-06-11 17:24:40	4	1	402	0	154	351	11	83.20	28	65.09	CHANGED	l+NahEclVhctlpp......tphpp..t.tspcslsDlsslALNpLPP+Ylppchshh.ahh.spptcpphcpplhsAlpcAhphVpppspc	..........l+NhhEplVhph.lsp.h...........ph..p......t.hspcpls..DlsslALNpLPPhYlppchshh.hth..sptthtphcsclhtAlppAhthltps.p................................	0	52	109	135
+10552	PF10720	DUF2515		Protein of unknown function (DUF2515)	Mistry J, Coggill P	anon	PRODOM_PD131865	Family	This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.	25.00	25.00	28.30	28.20	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-11.93	0.70	-5.52	19	260	2009-01-15 18:05:59	2008-06-12 09:26:28	4	2	151	0	33	210	0	311.30	50	86.73	CHANGED	llptIcccTchtNpDNISRTpAYhpaY.RaPEI+WuhLAoMVSRNuGWsMTDL+GphapplLsppppcthFLhYERANWlIFpDAYPQLLLYE.S++pspPLFHLLshFpVSpFMppEWp+FWcctspcRLhhALIINEQNhIQpPlIppsha++pVFcol.Fhlp-hhHFssVlFPshcG.......tLaGholpcFpslccRIpLGKpLupLLFcsch.hsphhcFAhpssHTGSRhDY.pahh.......................Gsp+htSPtLRpsasslsHphssp.pDWFpcpt..shhh.hppp.scphclT-hYh+Kpcplphhhhlpc	......llppIKcpTchhNtsNloRTpAYhpaYhRasEI+WAhLupMVSRNuGWNMTDL+GchYsplLscpsppphFhhhERuNWLIFpDAYPQLLLYEpSp++ppsLFHLLsahNVStFMEp.WphF..Wc.................ptst.ppLhhALIINEQNhlpK.VIpNsaFKKpVhpohhFKLp-hhphspllFPhh.Es...................hLaG.olppFpoLpcRItLGK+LhuLL.F+spa.huphhpaAtppsHTGSRtDY.salh..........................suh+haSPsLp.sa.shtHcEhc....h.cDWFscht..shha.hccE..phpspITE.Yp+phEpIthA.lsp.+................................	0	8	20	21
+10553	PF10721	DUF2514		Protein of unknown function (DUF2514)	Mistry J, Coggill P	anon	PRODOM_PD034813	Domain	This family is conserved in bacteria and some viruses. The function is not known.	24.70	24.70	24.80	24.90	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.01	0.71	-4.54	17	309	2012-10-02 17:03:51	2008-06-12 11:24:49	4	3	255	0	30	214	1	150.60	41	93.15	CHANGED	WhhhhhlllLshs.hhsh....a...ttGpphpstsatpchA..........cccus....pt.stltspstARtcEQcRptAtscstpcAppctstApAsAssAsAuuspLRppsscL....suuppt.ssssuAsspupsAucsuhVLu-lLu+usppAtpLActuDcuplAG.sCE+tYDulpt	...........................................................h...hhhllhhshh...G.........a....hhGsshuDp..uWppK.WA..........-RDuu......t.oppl.ssphuA.Rh.hEQtRphApDEssKDAQpctAchp..AcAAs...hus.uss..pL.Rs-up+h....lsA..A+c..sushAAAspuKospsstshLsshLG-hstcApha.AchADcpa..hAGhTCpphY-olp.s...............................................	0	3	8	19
+10554	PF10722	YbjN		Putative bacterial sensory transduction regulator	Mistry J, Coggill P, Bateman A	anon	PRODOM_PD093695	Domain	YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabiliser for some other unstable proteins [1]. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.20	0.71	-4.10	185	1845	2012-10-01 22:01:34	2008-06-12 12:57:55	4	8	1501	2	429	1139	363	127.10	20	69.51	CHANGED	sh-hlpphlpptshp.....hph.....tp-.spts..............ltsphpshthhhhhts..........pspthth.......shsh.hphs................pptsthhphlsphNpphhhs+h..hh.pppsthh.....hchslsl.....ttulospplpphlptshptsppahstlpt	.....................................................................phlcphlpphshp.....a.p....sss.spuh............hhsphpsh.p..hhhshp............-h.s.hl....hhu.h.h.tcl................sssh.slhthLsthNt...pt.hhs+h...hl..ctp..scsh...........lptslsl......tGl..o....c..p.h..t..hhlpps.cthphhh.....t..................................	0	128	285	369
+10555	PF10723	RepB-RCR_reg		Replication regulatory protein RepB	Mistry J, Coggill P	anon	PRODOM_PD763888	Family	This is a family of proteins which regulate replication of rolling circle replication (RCR) plasmids that have a double-strand replication origin (dso). Regulation of replication of RCR plasmids occurs mainly at initiation of leading strand synthesis at the dso, such that Rep protein concentration controls plasmid replication [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.76	0.72	-4.25	15	388	2012-10-02 18:44:02	2008-06-12 13:18:45	4	3	310	2	20	199	17	75.20	41	85.33	CHANGED	M.....SQhtNAVTSSsssKRtYRKGsPh........osAE+Q+suluRK+tTHKclpVFlpNtLK-pLhplCcccGlTQAEhIEcLIcpEhscps........p	...............................M.SQhtNsVTSSs..KRhYRKGpPl.........osuE+QphuluR..K....+so......+K.....clpVFlpsphKshLtphCcccGlTQAEhlcc.LIcpEhtth..s..............	0	3	7	14
+10556	PF10724	DUF2516		Protein of unknown function (DUF2516)	Mistry J, Coggill P	anon	PRODOM_PD057095	Family	This family is conserved in Actinobacteria. The function is not known.	25.90	25.90	27.00	26.70	24.50	25.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.35	0.72	-4.01	22	270	2009-01-15 18:05:59	2008-06-12 13:23:55	4	2	269	0	89	211	12	99.70	35	97.19	CHANGED	M...............hlhsltshlhhlLtlsshssulaAhlcuAhpRsDAFsAAsKtTKshWLsILGlulhlhllhh........shlshhul.luslAssVYlsDVRPtlcplp.................hssW	........................h.thlhhlLhlssllsulhAhVcAAhpRsDAasAADKhoKshWlsILGsAs.hlshlh......................sslsh.Luh..lu...hlAsuVYllDVRPpltplp...............G.....h.......................	0	25	67	85
+10557	PF10725	DUF2517		Protein of unknown function (DUF2517)	Mistry J, Coggill P	anon	PRODOM_PD055257	Family	This family is conserved in Proteobacteria. Several members are annotated as being protein YbfA. The function is not known.	25.00	25.00	41.40	41.20	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.18	0.72	-4.29	11	540	2009-01-15 18:05:59	2008-06-12 13:48:29	4	2	535	0	42	123	1	62.40	80	92.11	CHANGED	hYpsYPhapIlLRRhhVlLsGlLALPVMLFh..+DRARFYSYLHRVWsKTSDKPVWLpQuEpusp	...LY+-YPAalIFLRRoaAVsAGVLALPhMLFW..KDRARFYSYLHRVWSKTSDKPVWMsQAEKAT.s...	0	1	10	24
+10558	PF10726	DUF2518		Protein of function (DUF2518)	Mistry J, Coggill P	anon	PRODOM_PD032672	Family	This family is conserved in Cyanobacteria. Several members are annotated as the protein Ycf51.  The function is not known.	25.00	25.00	25.20	133.60	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.70	0.71	-4.66	26	73	2009-01-15 18:05:59	2008-06-12 13:59:10	4	1	73	0	29	78	119	145.00	41	86.59	CHANGED	M..shsphltpsstWluauulshulLTllAFlhpWGlRFRLVGlTuFolLLosusaAFulua.ps.stl-GAlphslVaDNGsshlVspsssshsspslpsTLcQlAuNL+usGRsus....pVplRlRplppspsGlScPllLGElpRs	........M.hst.hhshspWhuhuolshslLTllAFlh+WGlRFRLVGlTuFhhlLosuhauhuluh.hs+spI.GAl+aslVYDNGusplVlslssslstsplEATLcQAAsNLhShGRsus..ptplsIRhRslhHspsGlScPlhLGclpR....	0	5	19	27
+10559	PF10727	Rossmann-like		Rossmann-like domain	Bateman A	anon	Bateman A	Domain	This family of proteins contain a Rossmann-like domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.57	0.71	-4.41	8	557	2012-10-10 17:06:42	2008-06-12 16:45:08	4	5	547	4	188	1095	262	118.70	31	39.88	CHANGED	MptP...........p.sRLpVGIlSAGRVGsALGtAL-RAGHsVsuloAlScAS+pRAppRLPssslhsl.-lsc+uELllLAVPDA.ELsGlVpGLAsstssRsGpIVsHTSGApGlsILAPLscpGsIPLAIHP	.....................h.....................plGlIG.A.G+VGssLuhsL......p.p........s.......s....a..................l.....s.........u....s.....t........u....h....S.........p......s.........S......t.....p.....c.....A....t.....p.......h.....l..s....s............s.......s.......h............h.......s...............t....-...l.......s.......s..p...u..-.LlllsV.P.Ds...tl.ss.l.s....p....t...L...s.....t..t...t.....hp........s...G...p........l.ls.H..s..SG...A..h...u..ss.lLsP.hpptGu..hshulHP......................................................................	1	69	144	174
+10560	PF10728	DUF2520		Domain of unknown function (DUF2520)	Bateman A	anon	Bateman A	Domain	This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.	22.20	22.20	22.40	31.20	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.46	0.71	-4.70	98	840	2009-09-11 11:03:44	2008-06-12 16:53:23	4	12	824	6	260	779	206	129.80	28	45.49	CHANGED	ssshulEu...sppshslhp.plspplGscshhl.sscpRshYHsAAVhuuNalssLhshutclhpps..Glst.......................chLtPLlcsolcsh.hphGs.pALTGPls......RGDts.....TlppHlpsLpp.........sphtplYptLucthh	...............sshsl-u...sptsh.th.hp....sLstplGscshtl...spp.pRhhYHAAushuuNalsslhs..uhclLppt....Gls.......................................................................chLhPLlpsslcsh.hp.....p............G......p...............ALTGPls......RGDts.....slppHLphLps............sphtphYphhupth.h................................	0	101	200	242
+10561	PF10729	CedA		Cell division activator CedA	Pollington J	anon	PRODOM	Family	CedA is made up of four antiparallel beta-strands and an alpha-helix. It activates cell division by inhibiting chromosome over-replication. This is mediated by binding to dsDNA via the beta-sheet. [1,2].	25.00	25.00	79.50	79.40	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.74	0.72	-4.43	3	438	2009-01-15 18:05:59	2008-06-19 16:21:05	4	1	434	2	15	70	2	79.30	91	97.33	CHANGED	lMKPLRQQNRPIISYVPRVEPAPPEHAlKMDuFRDVWhLRGKYVAFVLMGEHFRRSPAFSVPESAQRWANQIRQEGEIpE	MKKPLRQQNRQIISYVPRTEPAPPEHAIKMDSFRDVWMLRGKYVAFVLMGESFLRSPAFTVPESAQRWANQIRQEsEVsE.	0	1	1	8
+10562	PF10730	DUF2521		Protein of unknown function (DUF2521)	Pollington J, Finn RD	anon	PRODOM	Family	Family of unknown function specific to Bacillus.	25.00	25.00	115.60	115.00	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.90	0.71	-4.38	10	131	2009-01-15 18:05:59	2008-06-19 16:34:35	4	1	131	0	18	56	0	143.40	62	99.77	CHANGED	MsVIsSFs-++REKQlcaEKplLRELSLcplppul+caFtsl.asFhpphpshlp-uCIDhAIEAYLLGu+aG+FGYYGEshpclptRstcEEccLscsLasaLpsWup.tpsptsp-sLYtAscpFIssWWpEGFpcucKRaKLRLH	...MNVIVSLpEKQKEKQLKYERKMLRELSLKTLRoNIRDAFp......MQELHRQYEDYCIELGIESYLLGARYSKFGYYGESFFDVKYRALEEEQQLTETLFQFLTSMThREIcLpDEELLFESCQQFIGhWWQEGYEKGERRYRLKLH.	0	3	10	12
+10563	PF10731	Anophelin		Thrombin inhibitor from mosquito	Coggill P	anon	Rawlings N	Family	Members of this family are all inhibitors of thrombin, the peptidase that is at the end of the blood coagulation cascade and which creates the clot by cleaving fibrinogen.  The interaction between thrombin and fibrinogen involves two different areas of contact - via the thrombin active site and via a second substrate-binding site known as an exosite.  The inhibitor acts by blocking the exosite, rather than by interacting with the active site.  The inhibitors are from mosquitoes that feed on human blood and which, by inhibiting thrombin, prevent the blood from clotting and keep it flowing.	25.00	25.00	27.70	105.10	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.09	0.72	-3.87	4	8	2009-09-14 14:04:23	2008-06-19 16:55:34	4	1	5	0	1	8	0	64.60	58	71.31	CHANGED	MAoKLlVIAhLClALlA.lVQuAPQYApG-EPoYDEDD.s-EslpPHSSSssD-s.--FDsSLL-c	MAoKLFVIAhLClALVA.lVQuAPQYApG-EPoYDEDD.s-EsLpPHSSSsoD-s.-EFDsSLL-c.	0	0	1	1
+10564	PF10732	DUF2524		Protein of unknown function (DUF2524)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillaceae bacteria. 	25.00	25.00	73.70	73.50	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.92	0.72	-3.86	8	132	2009-01-15 18:05:59	2008-06-23 11:22:36	4	1	132	0	18	52	0	84.00	70	93.53	CHANGED	MATRQSV-EaLQ+sEpAl-aApEQacpAp+QEHYN-pEYS-AQhhLEsAVN-Ls+LshSAN-QQREQLaRhRLQLQpLQNpMIL	.MAERQSLEsYITQAEQAVEYAKEQL-pGMRQEHYNTMEYSDAQLQLEQAYNDLQsMQQHANDEQREQLNRARMAIRQLQHQMII.	0	2	10	12
+10565	PF10733	DUF2525		Protein of unknown function (DUF2525)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.	21.40	21.40	21.60	24.40	21.30	18.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.64	0.72	-4.13	4	435	2009-01-15 18:05:59	2008-06-23 11:30:14	4	1	433	0	18	61	0	57.80	90	76.89	CHANGED	DVDALLAAINEISESEVHRT.-Dsp+sslDGRchHTaRELAEAFELDIHDFSsSEVNR	.DVDALLAAINEISESEVHR..S..QND..SE..HVSVDGREYHTWRELADAFELDIHDFSVSEVNR...	0	1	1	11
+10566	PF10734	DUF2523		Protein of unknown function (DUF2523)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of phage related proteins whose function is uncharacterised.	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.32	0.72	-3.75	28	269	2009-01-15 18:05:59	2008-06-23 11:32:35	4	1	213	0	36	185	2	82.70	23	83.97	CHANGED	tsLhshLtslht.lls+l..LsulGluhsohsGlsshhsthht.htshhsulPs....sllslluhhGlspuluIIhuAlshRlshpsl	....................................h..LhshLh.lht.llh.+l........lhulshhhhs.h....ssl.thhs........hh....shlpsthsulPs...........shhthlhhhGlspuLshlhuAhsh+huhp..h......	0	8	20	28
+10567	PF10735	DUF2526		Protein of unknown function (DUF2526)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function is restricted to Enterobacteriaceae. The family has a highly conserved sequence.	25.00	25.00	49.60	49.50	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.51	0.72	-3.99	3	445	2009-01-15 18:05:59	2008-06-23 11:37:21	4	1	444	0	16	60	1	76.60	90	99.99	CHANGED	MSHLEEVpsRVDAAIAEuVIAHMNELLIALSDDAQLSREERYsQQQRLRTAIAHHGRQHKEDpE....ARREQLTKGGoIL	MSHLDEVIARVDAAIEESVIAHMNELLIALSDDAELSREDRYTQQQRLRTAIA.HHGRKHKEDME....ARHEQLTKGGTIL...	0	2	3	10
+10568	PF10736	DUF2527		Protein of unknown function (DUF2627) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to a family of Enterobacterial proteins. It has a highly conserved sequence.	25.00	25.00	29.40	48.80	16.40	15.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.80	0.72	-4.34	2	354	2009-09-11 09:21:57	2008-06-23 11:38:56	4	1	354	0	9	18	0	37.80	95	81.88	CHANGED	MCGIFSKEVLSKcVsVEYRFSA-PYluASsSNsSsLSM	MCGIFSKEVLSKHVDVEYRFSAEPYIGASCSNVSVLSM...	0	1	2	4
+10569	PF10737	GerPC		Spore germination protein GerPC	Pollington J, Finn RD	anon	PRODOM	Family	GerPC is required for the formation of functionally normal spores. The gerP locus encodes a number of proteins which are thought to be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor [2].	22.40	22.40	24.20	23.30	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.15	0.71	-4.50	8	149	2009-01-15 18:05:59	2008-06-23 12:10:43	4	2	142	0	20	99	0	167.80	53	85.78	CHANGED	IppLE+plpELQpElspLKp+PuTsI-RIEYKFDQLKIEpLEGTLNIGLNP.oDsp.slEsFpV.ssssssluhhpQ-pssplhppIcQpV-tYLsEEsPplLcpLEppY-spLD-o.+paIlEDI+KQhDSRIcYYlpphtpcpsssPspc....t-cIAptVK+DIp+Al-pFLpHIPs	......................................IhsLEcQV+pLQcELNEL..KsR....P....So....SIsKVEYK..FDQLKVEsLsGTLNIGLNP..uc..sp...pIEDFpV..-sETl.cVs.............PEs...-ssPcaaQ........sIhQchacYL-EEAhscIh+hEpcp.cosLDEhYRQhhl-DIKKQM-cRlsYYLSQsp...shEsh........sossc..hlc-hIlQthKpDI-+Ah.uFIpHIPu.................	0	4	12	14
+10570	PF10738	Lpp-LpqN		Probable lipoprotein LpqN	Mistry J, Coggill P	anon	PRODOM_PD017067	Family	This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein [1].	21.60	21.60	22.00	22.20	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.27	0.71	-5.01	19	257	2009-01-15 18:05:59	2008-06-24 13:21:36	4	3	90	0	49	152	0	179.40	35	72.00	CHANGED	ssssP..................................lspaLcppGVshps.sPpshsuLslolPhPsGWpshssPNlssuhslI.....upuhhhssApllVaKLhGsFDPscAIp.HG.sDuQth.sac.phsAShAsasGFPSShIEGoYc.sGhphpo.pRhVIATu...usp+YLVpLoVT.ohsspAs.stusss-AIlsGFpVus	...............................................st..shP.........tholt-YlcspuVphpPlpsss.su.slslPhPssWp...hs..sss..lsssassIs.p...usus.....sPsA.hllVhKLp.G.DhD.PAcslp.+uss-.uppLsuap...sssuShAsasGFPSu..h...lpGoYcp.s.Gh....p.hpsupRpVlssu.....sssp.YLVpLs..lT.shsspus.shusAscsIspGhpls.s......................................................	0	5	27	42
+10571	PF10739	DUF2550		Protein of unknown function (DUF2550)	Mistry J, Coggill P	anon	PRODOM_PD031809	Family	This family is conserved in Corynebacterineae. The function is not known though most members are annotated as either secreted, or membrane, proteins.	20.60	20.60	20.70	22.10	18.00	20.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.59	0.71	-4.19	20	360	2009-01-15 18:05:59	2008-06-24 13:38:10	4	1	358	0	88	232	1	130.70	34	85.61	CHANGED	sLslllssllhlh..lhRhhlhRphGuhssslR.....hsssss+GWphGlhRYssscLcWaRLhSLpstPchslsRpul-lhsRRsPpusEhhhlssssl.llc........lps....cs.sphElAhstsAhTuFhSWLESuPssp	..........lsslllhh.hhhh....hhRhh....hhRp.GuhssslR........sh.s.....uss.spG.WphGssRYs.ss.phcaYRlhSh+hhPshhLpRpulclh..s+..RsPp.s.-Ehhhhsssh..h..llp........lps...................+s.sshElAlDtsulTuhhSWLEuAPss.t.......................	1	28	67	84
+10572	PF10740	DUF2529		Protein of unknown function (DUF2529)	Mistry J, Coggill P	anon	PRODOM_PD099482	Family	This family is conserved in the Bacillales. The function is not known. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.08	0.71	-4.83	14	343	2012-10-02 15:05:26	2008-06-24 13:41:14	4	1	343	2	29	139	0	168.40	53	97.13	CHANGED	M.KIFoTQLoGlFsRIt-KEp.uIEDuARLLAQAllG-GplYltGhsEhpulthpAhputEshsSutsLs.sss...plssoDRVLlFsphssDtEshthscpLh-pGlshVslS.sstpcssslsphsclHIDhplptsLlPsED.GsRhGaPushsuLYlYauLphslcEhL	...............................................MSKILsTQLhGIFNRl.EKQpL-IpMAAQsLlQ.AIGGEGaVYlKGYcDLpaaEoa.....lLaScE+LKSS++Lc.sl...pchpEIDSTDRVLLFuPFYsD.pVshDlpKLl-hDlDlVLIS....N.......pPKT-....DhP-HLsHaIDLSTPRPIVYTED..Y.DKIlQPHsMAhNYlYY-IYTQMlEMs.........................	0	7	16	23
+10573	PF10741	T2SM_b	GspM_II;	Type II secretion system (T2SS), protein M subtype b	Mistry J, Coggill P, Desvaux M	anon	PRODOM_PD110875	Family	The T2SMb family is conserved in Proteobacteria and Actinobacteria, and differs from the T2SM proteins in Vibrio spp. (Pfam:PF04612).	21.50	21.50	21.50	21.50	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.08	0.72	-4.44	28	187	2012-10-02 17:03:51	2008-06-24 13:57:02	4	3	172	0	71	217	26	108.80	24	55.89	CHANGED	tusssaltusssshAuAsL.p+lpshlsps...GsslsooQhhs..sspup.....hsplulplshcsshssLpplLhsLEsupPhLaVDpLslps.......shsssssups..Lplphsluuhh	........................t.t..al.st.ssshAuA.sL.pclpphlsps...Gs..ssttsphhs..hp...s.psp..............hsplslplplps....sh..tsLtslLhsLEstp.PhLhl-pLslpt..............phttssstts.tLplthtltuh...........................	0	24	42	58
+10574	PF10742	DUF2555		Protein of unknown function (DUF2555)	Mistry J, Coggill P	anon	PRODOM_PD060530	Family	This family is conserved in Cyanobacteria. The function is not known.	25.00	25.00	74.40	74.30	24.40	19.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.62	0.72	-4.34	21	69	2009-01-15 18:05:59	2008-06-24 14:57:06	4	1	69	0	28	62	107	56.90	55	77.10	CHANGED	lot-plssFscpslApLApRLE-DDYssPF-GLpDWHLLRAlAhpRPELspPYlHLl	....otcclsuhTpp-VApLApRLEpDDYssPF-GLpDWHLLRAlAFpRPELscPYlHLL.	0	5	18	26
+10575	PF10743	Phage_Cox		Regulatory phage protein cox	Mistry J, Coggill P	anon	PRODOM_PD064131	Family	This family of phage Cox proteins is expressed by Enterobacteria phages. The Cox protein is a 79-residue basic protein with a predicted strong helix-turn-helix DNA-binding motif. It inhibits integrative recombination and it activates site-specific excision of the HP1 genome from the Haemophilus influenzae chromosome, Hp1. Cox appears to function as a tetramer. Cox binding sites consist of two direct repeats of the consensus motif 5'-GGTMAWWWWA, one Cox tetramer binding to each motif. Cox binding interferes with the interaction of HP1 integrase with one of its binding sites, IBS5. This competition is central to directional control. Both Cox binding sites are needed for full inhibition of integration and for activating excision, because it plays a positive role in assembling the nucleoprotein complexes that produce excisive recombination, by inducing the formation of a critical conformation in those complexes [2].	23.70	23.70	23.80	28.90	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.87	0.72	-3.96	6	218	2009-01-15 18:05:59	2008-06-24 16:14:00	4	1	186	0	11	94	0	81.20	49	85.59	CHANGED	M.......ppQlophsoDhlsh-tFAphIGKTspAVppMlcAGKLPslcMpDPppssG+.GEhWlahsEWsphs+phh-otPsE....WhhWhsh	...............lhth.hDAl.hpcFAchlGKs.sAVppMlctuKLPlI-h.p.DPppssuRAGEhWValPtaNcul+pAa.sRPhE.RDuWLhWhGL.......	0	1	5	8
+10576	PF10744	Med1	Med1-Trap220; 	Mediator of RNA polymerase II transcription subunit 1	Wood V, Coggill P	anon	Pfam-B_51442 (release 22.0)	Domain	Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II.  This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions [1]. Med1 is part of the tail region of the Mediator complex [3].	21.10	21.10	21.30	21.50	20.40	21.00	hmmbuild  -o /dev/null HMM SEED	393	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.24	0.70	-5.70	30	276	2009-01-15 18:05:59	2008-06-24 16:21:09	4	5	202	0	189	267	0	357.00	20	39.21	CHANGED	l................s-hlphlhthh.tth..............sl-slp+hsphhuh-uhs-cl.....................clshtpshlsl-lDhspt.pshlhsstLhl........................................th.hss.psphsphphuh.tp...ps.stLhphhptpshscFppsLphLspl.phss...........................................p.ptchshFtAlcsLtpsLp........th.ph..pptsss.phpphhpsshGhhthc..pss....chthplpYahpst.lhctpp...........................................h..shphhtssthtshhNpssphpsssssthh.hhs..hs.........P.hhh.sppsssphssshshhlspshs...................................................................................pt.h..h.....st.ppapYths........sshps.tsph.lpclshscspplstllsl.............................................LRp.sh..hssLlposhpppt	..................................................................................................................phhphlp.hh.t................sh-sl.p+hhp.h.uht..shh-ch....................................p..htt.ph....ls.........clsh..stt....p....shlpsshhhh..........................................th..s.s.tsphs...sh.phth...tc..............ps...........t.h....spth...p.t...........pshspFptpLctLspl.pLst.................................................................................p.chpha.AlpultpsLp........................ph..h....ph..........................p.........t.s.s.........t.........t............hp.........p......h.h.pup.h.Ghht.+....pss....+l.hslpYahs.tplhptpp................................................................ht...h......ts.......sht...hstssp....tss.st....hh...hh.......s.hhts..............Psh......spsspsphs..s........sh.hphspshs...sht.lttht.sh.hsh................................................................h....tpt............tpp.t.h..h..sh...........s..t.....ppHsYhh................shpsh.Gph...lpclsFpHPtplshllsl.............................................LRp.sh..hssLltsshp...s...............................................................................................................................................................................................	0	46	83	151
+10577	PF10745	DUF2530		Protein of unknown function (DUF2530)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to mycobacteria.	22.40	22.40	22.40	23.00	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.55	0.72	-4.00	10	133	2009-09-11 11:12:09	2008-06-25 13:38:17	4	1	133	0	42	94	37	75.50	49	87.02	CHANGED	sspPPPLPssLL-PhPVIsVGsLuWLV.AsVsAFsVsu.LcsWRPlTlAGLuVGlLGToIFLWQR+AARRGuRGAQsGL	...............h..psPsLPssL.l-shPVIsVGsluWLV.As..V.sAal.Vsu...l....s.....s.....WpPV..olAGLusGl.LGTsIFlhQhuAARRGuRGAQtGL.........................	0	12	31	38
+10578	PF10746	Phage_holin_6		Phage holin family 6	Pollington J, Finn RD	anon	PRODOM	Family	Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis.	20.10	20.10	20.90	20.60	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.21	0.72	-4.25	4	52	2009-01-15 18:05:59	2008-06-25 13:44:29	4	1	39	0	1	40	0	62.70	52	94.44	CHANGED	LpLDFsNEVlKAAPIVGTusADsAuRlFFGLoLNEWFYsAAIAYTVVQIGshVhcslhc.K+tsKs	.....................LsLDFNNEll.KAAPlVGsusADsuARLFFGLSLNEWFYVAAIAYTVlQIGAhVhcplhcaK+ts+..........	1	1	1	1
+10579	PF10747	DUF2522		Protein of unknown function (DUF2522)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus.	25.00	25.00	43.10	43.10	24.00	23.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.84	0.71	-4.15	12	130	2009-01-15 18:05:59	2008-06-25 13:45:38	4	1	129	0	20	70	0	140.40	55	97.14	CHANGED	RpY.lYLIc-EhApaYFGREphhFcLFp-hchss..tppcplhtKQlpYITcslPhh+hcptLpptL.s+.hphpphpshapl....stcuputlhlt-+hIpltspGshsAEoshFElLRKlsssFLAhDhpsp+aGWLs.Pl+tcp	......+TYELYLIpEDlA+uYFGREhLFF-LFscao-Su.ohSEKcVLhKQhhYIThPLpVh+IHH+LEQsLcsh.u+YcRs+aTHsL...aoGApauEIMVKs+YIchsoSGNlShETTFFEVLRKsEhTFLAMDYENsKYGWLN.PLKQs.+...	0	4	12	14
+10580	PF10748	DUF2531		Protein of unknown function (DUF2531)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	22.00	22.00	22.00	22.80	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.95	6	489	2009-01-15 18:05:59	2008-06-25 13:47:50	4	1	480	0	33	166	0	125.50	64	94.58	CHANGED	pspRWlLLshsLshLTGMRDPF+PPEDRCRIucLspWRYQGhVucG-plsGlLKDuQpKWRRVcpsphL.sGWplspLTAsplsLpTGcGC-PspWRWpRpGspsE.AMDSpsssssssRtttu+usppDAsGG	................+spRhl.L.hsluLs.LLTGMRDPF+P.P.E.D.h.C..R..I..u..E.L..S..QWRYQGhVG+GERhIGlIKDGQ+KWRR.VppsDlL.E.N.G.WTIlQLTs-sLTLsT...GsN...C..EPPQWhWQRQ.Gc.s.NE.AMD...S...+sTssuD.sRRTGGKuucSDAsG...............................	0	2	7	20
+10581	PF10749	DUF2534		Protein of unknown function (DUF2534)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	21.40	21.40	22.20	53.20	20.40	21.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.59	0.72	-4.06	4	453	2009-01-15 18:05:59	2008-06-25 13:49:56	4	2	450	0	21	70	0	83.00	86	88.81	CHANGED	MIhhtKLpotcGKKFLluLhlVFhlAhoVVuRAThsGVlEQYNhPhScWToSMFhlQuAMlhVYSlVFThLlAIPLGhaFLGuc-	.........MIMAKLKSAKGKKFLFGLLAVFIIAASVVTRATIGGVIEQYNIPLSEWTTSMYVIQSSMIFVYSLVFTVLLAIPLGIYFLGGEE..	0	1	1	11
+10582	PF10750	DUF2536		Protein of unknown function (DUF2536)	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp. Structural modelling suggests this domain may bind nucleic acids [1].	20.50	20.50	23.30	22.50	20.20	17.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.14	0.72	-4.39	8	132	2009-01-15 18:05:59	2008-06-25 13:52:36	4	1	132	0	21	57	3	67.80	71	93.71	CHANGED	MNFpLDLIcDKVEFFEApcLpsLEKKIN-QIEpNKAILLpVHsVSHQspVs.csGRhhYSAVVHFKAKp	....MsFoF-MLEDKVEFFEAuDLsSLE+KIuEQID..NNKALMLEVHHISHQMlhDPESKRPYYSAVVHFKLKK....	0	5	13	15
+10583	PF10751	DUF2535		Protein of unknown function (DUF2535)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	82.70	82.60	21.70	18.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.97	0.72	-3.84	9	124	2009-01-15 18:05:59	2008-06-25 13:53:25	4	1	123	0	16	49	0	82.80	65	95.60	CHANGED	MLhKSLEFKpssGppVKloEIPVLcpDpPahFhlphRLphaltclapupsp+sVYSFR-YLKRplKWsDYpplappstLKHNA	..ITKSFYFTHSTGpCIKIFEIPVLQuQHPLuFLIQSRLQLFIAKIQKpK+PRFSYSFREYLQsCLKWNDY.NVYKTNTLEKNA	0	2	8	10
+10584	PF10752	DUF2533		Protein of unknown function (DUF2533) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	48.10	48.00	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.80	0.72	-3.68	10	130	2009-01-15 18:05:59	2008-06-25 14:56:50	4	1	130	0	17	59	0	83.60	69	94.30	CHANGED	hpVH+AITAHS+KQ+pplKpFlpLDtcREtAIE-AVscC+pGcsFoTDsINcITccMN-LAKpGIVPpRKlVTsEMV+EYVuRh	.MEVHKAITAHSRKQNEuVKAhLQLDAQREAAIEAAVSLASNGKcFSVDlINsVTKQINsLAKN.G.Vo.QRKYVTcEMVMEYVSRL.	0	3	9	11
+10585	PF10753	DUF2566		Protein of unknown function (DUF2566)	Mistry J, Coggill P	anon	PRODOM_PD060138	Family	This family is conserved in Enterobacteriaceae. The function is not known.	22.10	22.10	23.00	23.00	22.00	20.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.91	0.72	-4.05	7	798	2009-09-11 10:22:14	2008-06-25 16:39:19	4	1	477	0	30	144	2	53.90	69	84.61	CHANGED	hapthLlhYhlGhslohhlhahlS+D.phpIRhluAhllGlTWPhShPVsLLhSLF	......Lap+hLlFYslhssIuFlIhWFlSH-.Kp+IRhLSAFLVGhTWPMShPVALLFSLF............	0	2	7	17
+10586	PF10754	DUF2569		Protein of unknown function (DUF2569)	Mistry J, Coggill P	anon	PRODOM_PD088965	Family	This family is conserved in bacteria. The function is not known, but several members are annotated as being YdgK or a homologue thereof.	25.00	25.00	25.10	25.70	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.84	0.71	-3.99	15	609	2009-01-15 18:05:59	2008-06-30 10:56:40	4	5	578	0	63	219	7	142.60	64	86.26	CHANGED	ssshp+IGGWLlh.PhshLllo.lss.lsllhhh.ulhsstsaphLsupssshh.....hhhhhullhslsMa..........haTLalshLFF+R+pthP+haIlhlLloll.lslcuaAh........oPl.DshAl+plhhsLLuAslalPYh++ScRVKpTFlc	............T.TsPQRIGGWLLG....PLAWL.LV.AL......LSso......LA.L....L.LY...ssALuoP.QTFpTLuuQuhssp..........lLWGlSFITAI.....AMW..........YYTLWLTIAF..FKRR.RCVPK.HYI..I.WLLlSVL....L..AVKAFAF............SPVpD...ul.A..VRQLLF.....sLL..ATALIVPYFKRSuRVKsTFVN...	0	10	20	42
+10587	PF10756	bPH_6	DUF2581;	Bacterial PH domain	Mistry J, Coggill P, Bateman A, Ginalski K	anon	PRODOM_PD034109	Domain	This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales.  Although several members are annotated as RbiX homologues, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.28	0.72	-4.09	95	695	2012-10-04 00:02:25	2008-06-30 11:00:18	4	2	302	0	232	583	18	75.20	24	44.92	CHANGED	RsRltlsssG..lslRslh.us+hlsWs-Itslp...hspusph...........sclchsD....sphlsl.ulphs.st.ptshsuhsplt.s	..................RsRlts.sscG....lslRshh.ss+hlsWsplt.ulp..........hspu.sph........................................splchs-..................sph.lsl.u.lphs.sh.thshsuhtth...s........................................................................................	0	71	179	218
+10588	PF10755	DUF2585		Protein of unknown function (DUF2585)	Mistry J, Coggill P	anon	PRODOM_PD589556	Family	This family is conserved in Proteobacteria. The function is not known.	25.00	25.00	38.50	38.10	17.70	16.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.22	0.71	-4.80	20	70	2009-01-15 18:05:59	2008-06-30 11:03:00	4	1	69	0	27	80	10	161.90	57	83.99	CHANGED	lLhuMGRsPICsCGhVKLWcGsltSucNSQHluDWYT.SHlIHGFLFYuhsaLlhtRhs........huhR..LhlAlhlEuAWEIlENSshII-RYRsuTIuLDYhGDSllNSluDhlhMllGFlhAuRLPValTVslAIuFElhsuhlIRDNLTLNVLMLlaPlEAI+pWQuG	...............LahMGRlPICpCGh.VKLWcGsVsSStNSQHluDWYT.SHlIHGFLFYuLsaLlht+tP..........huhRLhlAhlIEuuWEllENSPhII-RYRsuTIuLDYaGDSIlNSshDTlhMhlGFlhA.tRLPVhlTVslAIsFElhsuhhIRDNLTLNVlMLlaPl-AIKpWQuG.................	0	6	14	18
+10589	PF10757	YbaJ		Biofilm formation regulator YbaJ	Pollington J, Finn RD	anon	PRODOM	Family	YbaJ regulates biofilm formation. It also has an important role in the regulation of motility in the biofilm. YbaJ functions in increasing conjugation, aggregation and decreasing the motility, resulting in an increase of biofilm [1]	25.00	25.00	35.80	35.80	21.20	18.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.63	0.71	-3.98	4	531	2009-01-15 18:05:59	2008-06-30 11:44:24	4	1	529	0	38	112	3	120.80	84	98.44	CHANGED	MDEYSPKRaDIAQLKFLCEsLYDEuIAoLG-SpHGWVNDPTSAlNLQLNELIEHIAoFllsFKIKYss-u-LoEQlEcYLDDTasLFSSYGINs.-LQRWpKS+pRLFthFSspplCT.hpT	..MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYLDDTFMLFSSYGINhQDLQKWRKSGNRLFRCFVNAT+pNPsS.L.......	0	1	8	23
+10590	PF10758	DUF2586		Protein of unknown function (DUF2586)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.04	0.70	-5.40	17	164	2009-09-13 14:48:51	2008-06-30 11:53:10	4	2	148	0	26	149	4	324.10	34	83.60	CHANGED	uhGpVplNsLN.hQGshsplERphLFIGhus.p...N.hGpllslssQSDlDslLGtuDSsLKppltAAphNuGpNWsAhshslss-sp...a.sAlctA.ppshSsEuVV....lsssssspAplsshpstts-LhspaGRhVahlsAssGl......spspoWusYhsthssLppGlAuppVtlVPpLa..GsplGllAGRLCscuVoIADSPMRVtTGullG.LG....shPhDpsGh.LshAsLpuL-ssRaSVPtaYPDY-GhYWuDGphLDs.GGDYQsIEsLRVVDKAARpVRIlAIt+IuDRsLNSTPsSIAsscsaFu+PLR-MS+SsphsGppFPGEIcsPpDsDIsIsWho+ppVpIalhVRPYssPKpITssIhLD	.............................................................................................................................hspVplsthN.h.G.htplEphhLFlG.us..p...s....sphh.lsspoDhsthl...u.tss.L+t.lhAA..Nusps...W.uhs.h.lstssp............a.pAlctA.ptshShEhVl....lstss.sspsplsthtshttcLhsphGRhlahlhsstu.........tpspsWs-YhsthsslppulAsptVtlVPp...La...........G..sp..........Gl.l.AGRLs..sp....u....Vo...........lADSPsRVtTGull..s.ls......phPhDtsG..t.t.ls...hA...sLpuL-ssRaSVPhWYsDY-GhYWuDGpTLDspGGDYQsIEslRVlcKAuR+VRlhAIs....+I.u.D.R.s....LNST.....s..s...S.lssppphFs+sL..RcMup.usplsu....FP..G..Elh....sPpDs......DlsIhW.spptVplhhhlcsapsPhpIslsl.LD............................................................................................	0	6	15	19
+10591	PF10759	DUF2587		Protein of unknown function (DUF2587)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with no known function.	25.00	25.00	99.70	99.30	17.50	17.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.20	0.71	-4.87	15	199	2009-01-15 18:05:59	2008-06-30 11:59:36	4	1	198	0	76	162	39	164.30	68	89.78	CHANGED	GPDG.....................sspusp-.sscstspslsDLVEQPAKVMRIGoMIKQLLEEVRAAPLDEASRsRL+EIHcoSI+ELEDGLAPELhEELERLoLPFo--ssPSDAELRIAQAQLVGWLEGLFHGIQTALaAQQMAARAQLEQMR..ptALPsGhs.s..........pGpsptsttuts.G..s...........GQYL	............................sssthhs..............sp..-s-sccpulTDhVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRsRLREIHtoSI+ELEDGLAPELREEL-RLoLPFsED..us...PSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMR.....pt...ALPP.Gsutsst........tG.......................................h.......................	0	23	58	72
+10593	PF10761	DUF2590		Protein of unknown function (DUF2590)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	20.10	20.10	22.30	31.00	17.40	18.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.27	0.72	-4.29	18	127	2009-01-15 18:05:59	2008-06-30 13:00:03	4	1	114	0	21	86	3	99.70	49	93.49	CHANGED	lDLhIhssDlsLDuuspPhllssRsoIAQDIKHtIhESGLshpLIuERushhpsDhhpplELlVE-DtRLVPGTlplsEsssGplhlTApTh-aG....lslclsh	.lDLLIpssDhsLssGspPhhCssRtSIuQDIhHuIlESGLsscLlAERSPshRuDlhpphcLLlEsDcRllPGTlplsEp....s...splalTApTaDFG..slshpl.h........	0	5	12	14
+10594	PF10762	DUF2583		Protein of unknown function (DUF2583)   	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as YchH however currently no function is known.	25.00	25.00	51.90	51.80	23.20	19.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.83	0.72	-3.85	5	543	2009-01-15 18:05:59	2008-06-30 13:04:58	4	1	530	0	40	129	1	86.10	83	96.79	CHANGED	MKRKNAutLGNVLMGLGLVlMVsGVGYSILuclsQFNlPQFFAHGAllSIFVGALLWLVGARIGGREpVADRYWWVKHFDKRCRRssHR	....MKRKNASLLGNVLMGLGLVVMVVGVGYSILNQLPQFNhPQa.F..AHGAlLSIFVGAlLWLAGARVGGHEQVsDRYWWVR.HY.DKRCRRsDNR............................	0	1	8	23
+10595	PF10763	DUF2584		Protein of unknown function (DUF2584)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins have no known function.	25.00	25.00	25.30	25.90	20.80	18.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.62	0.72	-4.15	9	175	2009-01-15 18:05:59	2008-06-30 13:07:09	4	2	175	8	18	82	0	78.70	58	95.31	CHANGED	MGMPlEhNTMIVTKG+EpR..lEENlFpLEKEGYRlYPl-lPl-VRKTKcGEpoGoAhlpKLEWcsu+TpITYcLlSLpSTN	.............................M.hEhpThIl...op...tKEhR...............I..-.-.NlFpLch-GY+laslp..lslhKopE.EplGoAhlpKLEWENGKTpIsYpLlSLpSsN.......	0	2	10	12
+10596	PF10764	Gin		Inhibitor of sigma-G Gin	Pollington J, Finn RD	anon	PRODOM	Family	Gin allows sigma-F to delay late forespore transcription by preventing sigma-G to take over before the cell has reached a critical stage of development. Gin is also known as CsfB [1].	21.00	21.00	21.10	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.66	0.72	-4.25	21	219	2009-01-15 18:05:59	2008-06-30 13:09:27	4	2	219	0	51	130	0	46.10	44	71.70	CHANGED	hClICcpp+pc...GIhlhs+FICp-CE+cllsspss-spYpaYh++LK	.hCIlCcpc+p-....GIhlhsphICh-CE+chVsT-ssDscY.aYl+pL+.......	0	21	37	42
+10597	PF10765	DUF2591		Protein of unknown function (DUF2591)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.30	21.30	21.80	21.70	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.60	0.72	-3.84	16	234	2009-01-15 18:05:59	2008-06-30 13:18:17	4	1	198	0	36	151	1	106.50	32	91.15	CHANGED	McaScLSDhElNhhVAcApshp..h...........................s.h.hh..ps.sthttas.CssPuDAhPIIpcs+Iul..........tsssscWsAp...................ssssh.hh.spsPLRAAMIVFLh.p	....................................caupLSDhElNphVuth.htps..thh.........................t...s...h...hst...h..s.t.h....tshc.CssPuDuWPIIp+.t.+Iul................h.........sp.tspWsAp.............ssps.sh.h.h.sp...sPLRAAMIsFLh.Q...........................	0	0	9	22
+10598	PF10766	DUF2592		Protein of unknown function (DUF2592)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	25.20	25.30	18.90	24.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.88	0.72	-4.61	5	530	2009-01-15 18:05:59	2008-06-30 13:40:05	4	1	516	0	39	104	2	40.20	89	79.27	CHANGED	LLKSLlFAVVMVPVVMAlILGLIYGLGEVFNIFS+lG+oK-	.LLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGlG+KDQ......	0	2	8	23
+10599	PF10767	DUF2593		Protein of unknown function (DUF2593)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YbjO however currently there is no known function.	23.50	23.50	149.90	149.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.87	0.71	-4.50	6	522	2009-01-15 18:05:59	2008-06-30 13:44:05	4	1	520	0	34	121	2	143.70	77	88.68	CHANGED	hssPs.V.VAulAIIuhRsLslLhLhspLGlcGlu-FIpcSlQsWshTLlFhuSLlLlhlEIhCuFulh+GRNWuRWsaLlsQllssuYLhhASLGahhPElFoIsGES+t-IhHSLlLQKlPDlLlLsLLFlPupSRRFFtlQ	.L.NVPALVQVAAlAIIhIRGLDVLMIhNTLGVRGlGEFIHRSVQTWSLTLVFLuSLVLVFIEIWCAFSLVKGRpWARWlYLLTQIsAuuYLWAASLGYGY..PELFSIsGESKREIFHSLhLQKLPDhLILhLLFVPuoSRRFFpLQ.....................	0	1	6	19
+10600	PF10768	FliX		Class II flagellar assembly regulator	Mistry J, Coggill P	anon	PRODOM_PD868899	Family	The FliX protein is possibly a transient component of the flagellum that is required for the assembly process. FliX may contribute to the targeting or assembly of the P- and L-ring protein monomers at the cell pole. The family carries a potential N-terminal signal sequence and at least one transmembrane domain indicating that it might function either in or in association with the cell membrane [1].	25.00	25.00	40.10	39.90	21.20	19.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.88	0.71	-3.95	19	70	2009-01-15 18:05:59	2008-06-30 13:46:07	4	1	70	0	38	74	23	137.40	39	97.41	CHANGED	M.+l.Gssusosusuutsp..ppuGu.uuFulss...ssssspst..usuustuhuulD..ALLALQuh...-D...shER.R+RuVpRGcshLDsLD-LKhuLLsGplspusls+Ltssstph+suouDPtL-ulLsEIELRscVELAKhup...s	.................M.+l.Gssusssssuspss...ctsuu..uuFuh..ss...ssssspsp...usuustusuulD..ALLALQul.....-D....ssER..R+RuVpRGcshLDsLD-LKhuLLuGplssspLtcLtssltph+ssouDPtL-ulLsEIELRscVELAKhstt..	0	15	24	28
+10601	PF10769	DUF2594		Protein of unknown function (DUF2594)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Enterobacteriaceae.	23.70	23.70	72.10	72.00	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.37	0.72	-3.90	6	530	2009-01-15 18:05:59	2008-06-30 13:52:11	4	1	527	0	36	97	0	73.80	83	99.99	CHANGED	MSssDFoTuussppLAsEVoCLKAhLTLlLKAIGQADAG+VIlNMER.IAplEDspQAtVFsNTlpQIKpuYRQ	...MSTPDFSTAENNQELANEVoCLKAMLTLMLQAMGQADAGRVhLKMEKQlAhIEDEsQAAVFSpTVKQIKQAYRQ..	0	1	8	21
+10603	PF10771	DUF2582		Protein of unknown function (DUF2582)	Mistry J, Coggill P	anon	PRODOM_PD055730	Family	This family is conserved in bacteria and archaea. The function is not known.	24.20	24.20	24.20	24.20	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.30	0.72	-4.12	23	279	2009-01-15 18:05:59	2008-06-30 14:03:51	4	3	136	4	47	185	10	65.40	34	76.42	CHANGED	Mccph............IGtsAGclWphLs-..tschShspLp...+csuL.scc-lthAlGWLAREsKIthc.....cpstplhlpL	....................M.+pp........lGhsAGcVWphLsp..pt.p.hohppLp...+tspL..scc-lhhAlGWLuREsKI.php.....phpt.hhl.............	0	13	36	44
+10604	PF10772	DUF2597		Protein of unknown function (DUF2597)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	113.10	113.00	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.51	0.71	-4.25	29	118	2009-01-15 18:05:59	2008-06-30 14:05:21	4	1	113	0	20	81	2	133.10	52	88.93	CHANGED	psFDhslhshhVHVcssoloITDsSssspTRGVPDGaVDGDVuA-GElELDspsFphlspAA+sAGSaRulcshDhhFYApsGp.-EhKVEsFGsKlhloDlLsIDPcGGscss+KlKa.VTSPDFV+INGVPYL	..................hsFDshlsu.hlHlEphoLsITDNSAsAQTRGVPDGaVDGDVuA-GElElsopsFphLsstA+sAGSWRul.PhDhlFYApsGs.-EhKVEsFGsKlplSslLsIDP.cGGutsT+KlKahVTSPDFV+INGVPYL......	0	3	11	13
+10606	PF10774	DUF4226	BssS;	Domain of unknown function (DUF4226)	Pollington J, Finn RD, Bateman A	anon	PRODOM	Domain	This family of mycobacterial proteins are uncharacterised.	22.00	22.00	22.20	22.40	21.30	21.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.40	0.71	-4.03	9	168	2009-01-15 18:05:59	2008-06-30 14:13:42	4	4	64	0	19	82	0	109.40	45	37.19	CHANGED	cpsGsuA-AlpstcsALAcQpussu-sDtplssAlhsAHssss-Gtc+LstltpEI-sAVsppus.uLDTPAGAR-Fp+FLluKh+-ItpVVssAshpspuKuslhsuLsuhY	..........ptGsustslpsccuuLAppp..ussAEsDcplsssLtsAHsuhs-GtRRLcAIuAEI-sA...Vscpss.huLDTPAGAR-Fp+FLhuKt+-IppVVAsAst-upu+uAllcuLsupY........................	0	3	8	16
+10607	PF10775	ATP_sub_h		ATP synthase complex subunit h	Pollington J, Finn RD	anon	PRODOM	Family	Subunit h is a component of the yeast mitochondrial F1-F0 ATP synthase. It is essential for the correct assembly and functioning of this enzyme. Subunit h occupies a central place in the peripheral stalk between the F1 sector and the membrane [1].	25.00	25.00	39.30	38.50	23.90	17.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.12	0.72	-4.25	18	131	2009-01-15 18:05:59	2008-06-30 14:18:51	4	3	129	0	99	122	0	69.20	44	51.92	CHANGED	RsFSo..sstpt-llQDLYL+ELKuaKssPlsssDucGpV+pashPssPssPp....s-l..uu-.LcuYc.spsVE	..........RsFhs..ssppsDhVQDLYL+ELKAYKssP..h.....pt..sDA-G.....pVppFshPpsPpuPE....s-L...As-.LKuYEspsVE...............	0	27	55	84
+10608	PF10776	DUF2600		Protein of unknown function (DUF2600)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.	25.00	25.00	148.20	112.40	19.60	19.10	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.03	0.70	-5.60	29	211	2009-09-11 11:05:58	2008-06-30 14:30:12	4	2	203	0	50	164	0	326.10	55	92.33	CHANGED	PlVH+ELuhW+c+Ah+IPscEL+pQAlASIccKTFHCEGGuIhALLAs-+p--sIRFIVAYQTISDYLDNLCDRSTSLDPpDFtsLHpSMhtALoscsE..susYYRaR--Q-DGGYLc-LVcTCQcVLpchcpY-tItPhLpELAsYYCDLQlHKHVc.-.ERcPRLpsWF-ta+csLPt.MoWaEFSACuGSTLGIFCLVAYAacs-Lp-c-stKIRpuYFPYlQGLHILLDYFIDQEEDRhGGDLNFCsYYpscpthh-RhpHFlEcA-cplusLPHscFHRLIsRGLLGlYLSDpKVsuQ+ph++hA++llKhGGhsSpFFYhNG+hYRK	.........PlVH+ELshW+c+AhpIPssEL+sQAlASIccKTFHCEGGuILA.L.L.us.-c.+ccsI+FIVAYQTISDYLDNLCDRSTSLDPsDFttLHpSMh.ALoPcs-.....suNYY+aRc-QDDGGYLc-LVcTCQcVLpchp+Y-tItPhLcELAsYYCDLQlHKHVchE.EREPRLpsWF-tH+c.slP.-...MsWaEFSAC.uGSTLGIFC.LVAYAa.c.s-Lp-EchtKIRpuYFPYlQGLHILLDYFIDQEEDRhGGDLNFCoYYcscpthl-RhcHFlEcA-cslscLPHucFHRLIsRGLLGlYLSDpKVus.Q+.ph++hAR+llK.h.G.GhsShFFYhNG+hYRK..................	0	23	39	42
+10609	PF10777	YlaC		Inner membrane protein YlaC	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Domain	Members of this family include proteins annotated as inner membrane protein YlaC in E. coli and Salmonella. The function of this family is unknown.	20.30	20.30	21.20	21.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.03	0.71	-4.67	8	536	2009-01-15 18:05:59	2008-06-30 16:19:27	4	2	531	0	39	134	3	153.20	75	97.48	CHANGED	MsEIpRLLscsI-RlNpcEKRDN+PRFShsFIRcHPhLFlAMasualAsLsVMhhophh.hsSlhhhsVLFllhsAhhhhDlpPpYRaEDIDVLDLRVCYNGEWYsTRtVssphI-cILssPpVssshKsplcKhlssKGElsFYDVaoLAhspps	..............................MTEIQRLLoETI-sLNsREKR.DNKPRFSISFIRKHPGLF.IuMYVAaFATLAVMLQSETL.oGSVWLLVVLFILhNGFFFFDVhP...RYRYEDIDVLDFRVCYNGEWYNTRFVPssLlEsILNSPcVuDsHKpQLQKMIsR.KGELSFYDIFTLARAEuo......	1	1	7	23
+10610	PF10778	DehI		Halocarboxylic acid dehydrogenase DehI	Pollington J, Finn RD	anon	PRODOM	Family	Haloacid dehalogenases catalyse the removal of halides from organic haloacids. DehI can process both L- and D-substrates.  A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuration of either L- or D-substrates in contrast to D-only enzymes [1].	21.50	21.50	21.50	23.20	21.30	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.63	0.71	-4.71	12	73	2009-01-15 18:05:59	2008-06-30 16:26:33	4	4	42	4	8	69	11	122.20	37	74.63	CHANGED	WVuhsh+shApaspFlstuWpthcsthtTRhhEcuA-plRtto...lhs..hshss.sttLhutGas.t-lccl+ssl-hFsYGNPKYLllhoAhpE.uhptRshuGts...hsut.ssphPhGhsp.h...hpLl-.ccAspcspplLpDItcshhphtsuSDa	..aVuFshRs.hupaPsFlstAWtsh+PslpTRaAEcuADtlRhpS...lssu...sshss..Ts.+.LhthGas-p-Iccl+ssLDlhNaGNPKhLl......................................................................................................................................	0	4	7	8
+10611	PF10779	XhlA		Haemolysin XhlA	Pollington J, Finn RD	anon	PRODOM	Family	XhlA is a cell-surface associated haemolysin that lyses the two most prevalent types of insect immune cells (granulocytes and plasmatocytes) as well as rabbit and horse erythrocytes [1]. This family has had DUF1267, Pfam:PF06895, merged into it.	34.70	34.70	35.30	35.10	34.60	34.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.44	0.72	-4.06	47	409	2009-01-15 18:05:59	2008-06-30 16:30:38	4	1	232	0	46	250	1	70.50	30	88.24	CHANGED	hpclppclsplcsc.cp.......htpthpshEhtsthp-ps..........ltslscpLpcIppNppWlhR...hllGullsu....llshlhK	...........p-lhpclsplcschcp.......htpclcsLEpp...sstp-pc..........ItslscpLc+IssNspWllR....llluullsu....llshlhK..............	0	21	36	40
+10612	PF10780	MRP_L53		39S ribosomal protein L53/MRP-L53	Pollington J, Finn RD	anon	PRODOM	Family	MRP-L53 is also known as Mrp144. It is part of the 39S ribosome [1].	24.80	24.80	25.00	25.00	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.43	0.72	-3.99	20	175	2009-01-15 18:05:59	2008-06-30 16:32:23	4	2	165	0	124	165	0	51.80	33	44.15	CHANGED	FNPFutsu+sARLFLuhl.....ssos+stuhplpsclLscso..sppPplcVtFKDG	........FsPFstpu.+ssRhFLshl.......sst+sptoslsspllscss...pptPplpVtFtDG....	0	23	57	95
+10613	PF10781	DSRB		Dextransucrase DSRB	Pollington J, Finn RD	anon	PRODOM	Family	DSRB is a novel dextransucrase which produces a dextran different from the typical dextran, as it contains (1-6) and (1-2) linkages, when this strain is grown in the presence of sucrose [1].	25.00	25.00	26.50	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-8.96	0.72	-4.48	5	506	2009-01-15 18:05:59	2008-06-30 16:43:54	4	2	504	0	33	111	1	61.60	90	97.22	CHANGED	MKVNDRVTVKTDGGPRREGVILAVEEFSEGVMYLVSL-DYPAGIWFFNElDSpDGTFVEhts	.....MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNEuGHQDGIFVEKA.E....	0	1	8	20
+10614	PF10782	DUF2602		Protein of unknown function (DUF2602)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.20	26.20	23.60	22.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.18	0.72	-4.13	14	323	2009-01-15 18:05:59	2008-06-30 17:10:47	4	1	304	0	25	89	0	57.20	57	82.95	CHANGED	hs++phhtcls-L.spYCpuChlKcHhRKp.GKsaAHpFCIppCTlGcclKphGppLp	............scpphlscIsDLhsTYCppC.lKp+hRKhpGKTtAHpFCIscColGKpIKQlGspLp.....	0	4	10	17
+10615	PF10783	DUF2599		Protein of unknown function (DUF2599)	Mistry J, Coggill P	anon	PRODOM_PD414589	Family	This family is conserved in Actinobacteria. The function is not known.	25.00	25.00	25.70	28.70	23.70	24.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.40	0.72	-3.34	12	152	2009-01-15 18:05:59	2008-07-01 12:49:54	4	3	148	0	39	108	0	94.80	43	49.17	CHANGED	lD+spWspass......h.oLpVhPTpsGRpsstp.s.....tstAWsEllsLuP-............AsssGMRtQFlCHap..........aAchhtPuKsSWNLEPWRPsVssp-hlApGCNPG	...................l-pspWsphss......h.SLpVhPops.G.R..ss.sp.p.s.......h-sAWsEVluhsP...c............AsosGMRsQFlCHap..........aAc..........ssKsSWNLEPa.RPsVsss-hlAsuCNPG................	0	6	22	31
+10616	PF10784	Plasmid_stab_B		Plasmid stability protein	Mistry J, Coggill P	anon	PRODOM_PD189613	Family	This family is conserved in the Enterobacteriales. It is a putative plasmid stability protein in that it is expressed from the operon involved in stability, but its actual function has not yet been characterised.	25.00	25.00	25.90	25.30	23.70	23.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.15	0.72	-4.36	11	396	2009-09-11 13:35:50	2008-07-01 12:52:36	4	2	221	2	9	189	0	68.40	37	59.10	CHANGED	R+hohYLpP-t.puDphApshl-olspptRGchhRsAhlsGhALaplDPRLPhLlushhscphossplspll	.........R+hohYL+Pst.ps-t.Asthl-ols.ptRuch.RsAhluGhALhphDPR...hshlLushhs--hsssslsph..................	0	0	2	4
+10617	PF10785	NADH-u_ox-rdase		NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit	Mistry J, Coggill P	anon	PRODOM_PD104546	Domain	This family is the N-terminal domain of NADH-ubiquinone oxidoreductase 21 kDa subunits from fungi, lower metazoa and plants.	25.00	25.00	30.40	29.20	23.40	21.00	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.82	0.72	-3.74	35	183	2009-01-15 18:05:59	2008-07-01 13:39:47	4	2	163	0	125	165	0	84.40	35	51.07	CHANGED	hpocYPlI.....DsDP...ahpRVlsYhRsSDYshhuussuuhPshhahhEphsPstst.h......ssshRhushlGhhGGFhhsYpRSstRFhGapE	.......................hpscYPlI.....DscP............pap+Vlu.hRsuDYshhushuususshhahhtphssspht................usuMphuuhlGhhGGFhhsYQpSshRhhGapE...............	0	43	80	110
+10618	PF10786	G6PD_bact		Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Mistry J, Coggill P	anon	PRODOM_PD110134	Family	This family is conserved in Firmicutes and Proteobacteria. Several members are annotated as being glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49) but this could not be confirmed.	25.00	25.00	25.70	25.40	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.66	0.70	-4.91	9	269	2009-01-15 18:05:59	2008-07-01 13:44:42	4	1	265	0	18	153	0	202.90	45	98.10	CHANGED	hLospsh-lFshPhFpFtQlK.KasPE-IspIKA-YKtpWQhWKplp.pVupQLss..sFAcPHIEpWsNGWplRuHFaAhY+hph.pspuAhluVlLN++pLQVhL.appY+uD+pQholppYNphLspl....Dphchuca.lWctsEpEasDahslsph.....pppshshcsc-chaplGK.h.+sc.sh.DhtcFIhcTIccLhPLYE+h+	.......LTtpshsLFshPhFpFtQLK.pasP-cIspIKs-...YKppWppWKtl..pVAttLss...sFAcPHIESWsNGWpl.RuHFaAha+hEppp..spsAhL...ulLLN++pLpV.L.appYKu-cpthslspYNp.hLsph....cshchtsa.lWcts.EpEasDahslpph.....pppphphcsscchFpIGKhh.ps-.phpchtphhspslp-LhPLYpth................................................................................	0	3	7	12
+10619	PF10787	YfmQ		Uncharacterised protein from bacillus cereus group	Mistry J, Coggill P	anon	PRODOM_PD089522	Family	This family is conserved in the Bacillus cereus group. Several members are called YfmQ but the function is not known.	20.90	20.90	20.90	36.20	20.80	19.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.78	0.71	-4.85	7	191	2009-01-15 18:05:59	2008-07-01 14:15:02	4	1	116	0	14	119	1	139.80	65	98.44	CHANGED	MThWhIlhLVlFuhhKllVoslPouVVE.lluKFElHscLp--ssolohsG+pLEGppKpclIppFNEAlFL-+YYh.PusE.........GTPLlIpTKpGK+-VphalYpYDDHlDVVKQY....KKKllAYpLRScsLQsss.h.hstshh	.........MTTWFIVhLhlFGAhKllVSShPsoVlESIISKFEhH.KL-EE.NsoloIcGpNlEGEpK.plIH-FNEALFLD+aYhPPHsE.........GTPllIcsK+GKK-lpF.lYSaEE.HVDVlKQY....KKKVVAYpLRSKsLQsps.hhlotDh.A........	0	3	8	9
+10620	PF10788	DUF2603		Protein of unknown function (DUF2603)	Mistry J, Coggill P	anon	PRODOM_PD098479	Family	This family is conserved in Epsilon-proteobacteria. The function is not known.	25.00	25.00	74.70	74.50	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.74	0.71	-4.41	12	175	2009-01-15 18:05:59	2008-07-01 14:22:06	4	1	173	0	16	72	0	135.20	56	83.07	CHANGED	lschupsLGlpccp.pTlhchhp..psNEhhLpLcsGshspsEPWFhlDEpsph+sllohp.lptLlpslKpup+ENFcL+LEKsIhQphPlDFsDVWsVAh-EI++httpst.....sIslcpLlccIK+EHPNLFhshc	......................IDEhSpsLGhcKc-.RsIFKhKpops-NE+sLh..LEsGSFDo.sEPWFlhDENDclHTLlSlpSLpNILEsLKpuQKENFELRLEKAIaQQIPlDFsDVWpVAMDEIKppAQpss.c..lsIDL-KLlpcIK+EHPNLFVDMp.	0	4	13	16
+10621	PF10789	Phage_RpbA		Phage RNA polymerase binding, RpbA	Finn RD	anon	PRODOM	Family	Upon infection the RpbA encode phage protein binds to the ADP-ribosylated core RNA polymerase and modulates function to preferentially bind T4 promoters.\	     This is a non-essential protein to the phage life cycle.	21.00	21.00	21.10	22.50	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.43	0.72	-4.20	8	36	2009-01-15 18:05:59	2008-07-01 14:49:10	4	1	35	0	1	35	0	103.20	35	85.48	CHANGED	uDIpsp.hpo-us.cspNKIRKAWVLphsDsptcpLQul.Qc..sRFtLYupIDc-Vp-pWIcLMR++ps-uLssGuKhVhsh.GpchLtcpYphDsDEhLIsAAplV....huch	........tDIQsK.hpo-us.pspN+IRKAWVLphs.-sstctlQsh.pp..sRatlYptIDc-VpcpWI-LM+++ps-uLssGAKhlhsp.stchLEcpYphssDEhLl.AuplVhtp.h...........................	1	0	0	1
+10622	PF10790	DUF2604		Protein of Unknown function (DUF2604)	Finn RD	anon	PRODOM	Family	Family of bacterial proteins with undetermined function.	20.90	20.90	21.20	144.30	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.23	0.72	-3.84	3	5	2009-01-15 18:05:59	2008-07-01 15:11:21	4	1	5	0	3	5	0	76.00	69	56.89	CHANGED	VVVNGQPVsVEANVNAPLHsVlAKALEpSGNVGQPsENWELKDEuGsVLDlsKKVEDaGFTNGVKLFLSLKAGVAG	VVVNGQPTQVEANPNQPLHVVRAKALENTQNVAQPAENWEFKDEAGsLLDlDKKVGDFGFANsVTLFLSLKAGVAG	0	0	2	3
+10623	PF10791	F1F0-ATPsyn_F		Mitochondrial F1-F0 ATP synthase subunit F of fungi	Mistry J, Coggill P	anon	PRODOM_PD068018	Family	The membrane bound F1-FO-type H+ ATP synthase of mitochondria catalyses the terminal step in oxidative respiration converting the generation of the electrochemical gradient into ATP for cellular biosynthesis. The general structure and the core subunits of the enzyme are highly conserved in both prokaryotic and eukaryotic organisms.	23.00	23.00	23.00	24.40	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.12	0.72	-3.75	14	131	2009-01-15 18:05:59	2008-07-01 15:39:51	4	1	128	0	99	115	0	92.00	53	70.67	CHANGED	Mhh.....+RuLSTLI............P.PKlsosts.luuussAtRhtpVVsFYcpLPpGPAPthpss..uh.lu+YpAKYF..pGcNASG+PllHhlhullhhGYuh-YaFHL+	............................M.alhRRuLSTL.I......P.PKlA....Ssps.lGuAssA......tRMpcVVsFYc+LP+GsAPt..sKssGh...lGRYpA+YF...G+NASup...........PllHhlhullhlGYoh-YYFHLR............................	0	26	55	84
+10624	PF10792	DUF2605		Protein of unknown function (DUF2605)	Mistry J, Coggill P	anon	PRODOM_PD070476 	Family	This family is conserved in Cyanobacteria. The function is not known.	25.00	25.00	46.40	46.30	18.70	18.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.33	0.72	-4.32	17	56	2009-09-11 15:07:39	2008-07-01 15:50:20	4	1	54	0	21	59	22	96.20	46	90.09	CHANGED	ps.ststLLcslL-sLLcDFpaWFpRuccLLpsps.shhstc-ppsLhpRlcpupptltus+uLhpAostthuVsMpsMsPWHpLVsEsWtlAsRhppt	..sp.sps-LL+olL-PLL-DFpaWFsRucpLLEs-plsFhospEQpcLLsRV+pAQpEVpss+hLFpATstQsGl-hpshhPWHpLVsECWplutRaRp.h..	0	2	14	19
+10625	PF10793	Gloverin		Gloverin-like protein 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins are Gloverin-like. Gloverin is a 13.8kDa inducible antibacterial insect protein which inhibits the synthesis of vital outer membrane proteins leading to a permeable outer membrane. Gloverin contains a large number of glycine residues [1].	25.00	25.00	35.90	63.40	23.70	16.70	hmmbuild  --amino -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.93	0.71	-4.58	5	27	2009-01-15 18:05:59	2008-07-01 15:51:29	4	2	12	0	7	27	0	137.10	61	91.41	CHANGED	QVShPPGYAc+YPpYhKaSKpsRHPRD....VTWDKplG.sGKVFGTLGQNDDGLFGKGGYp+-FFNDHRGKLTGQAYGTRVLGPuGDSTNaGGRLDWANKNApAALDVsKQIGGRoGloASGSGVWcLDKNT+LSAGGsLSKsFGHsRPDVGlQApIpHDW	....................t..p.Ys.....S+..RHPRD....lTW-+phG.sGKVFGTLGpsDpGLFGKuGYppphFNDcRG+LpGQAYGoRVLGPsGDSTsaGGRLDW..uNcNApAAlDls+QIGGpoGhoAoGSGVWsLDKNT+LSAGGslSK.pFGHp+PDVGlQAphpH-a......	0	6	7	7
+10626	PF10794	DUF2606		Protein of unknown function (DUF2606)	Finn RD	anon	PRODOM	Family	Family of bacterial proteins with unknown function. These proteins have been classified as membrane proteins	25.00	25.00	25.40	99.40	24.80	23.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.49	0.71	-4.72	4	45	2012-10-02 19:08:27	2008-07-01 15:55:09	4	2	45	0	2	34	0	112.50	51	95.78	CHANGED	Ma.hIhp.G.lNKYsphlah....LsIlhhsuhhsss-pshpKsl.PVThHVcst-tpPlcshplhlhK..-ps.pPSpEIG..IGKTDccGclhW+ssRKGcYhVhLspsEsp.s....lhpD+cspplI.Isl	.............................hhsushuss-pphuKsl.sVThHVcNKEKpPlKsFEIhLMK..DpsPpPS+EIGISIGKTDcEGKlIW+ssRcGcYIVhLPNsETphl....hlNDRctsclIsIs.h	0	1	1	1
+10627	PF10795	DUF2607		Protein of unknown function (DUF2607)	Mistry J, Coggill P	anon	PRODOM_PD067168	Family	This family is conserved in Gammaproteobacteria. The function is not known.	20.50	20.50	20.90	20.60	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.51	0.72	-4.17	7	95	2009-01-15 18:05:59	2008-07-01 15:59:13	4	1	95	0	10	53	4	93.30	56	99.24	CHANGED	M..athpth.pph+Rpsl...huVsLhlhhshAsltHplDlsPEHHspHHCQLFuuspHGlsp.....u.P.l.sPsappt..pslhtpshphtplh..hhARuPP.hhu	...........................p+hsl..MLSVVLuLWFNVAVIDHQLD.LHPEHHLQHDCQLFASAAH...GLKT......SQWlL...P...SWRQNPP..QARVEQPIQ.RsQVLa.SYFARSPP....AA.	1	1	2	6
+10628	PF10796	Anti-adapt_IraP		Sigma-S stabilisation anti-adaptor protein 	Mistry J, Coggill P	anon	PRODOM_PD028886	Family	This family is conserved in Enterobacteriaceae. It is one of a series of proteins, expressed by these bacteria in response to stress, that help to regulate Sigma-S, the stationary phase sigma factor of Escherichia coli and Salmonella. IraP is essential for Sigma-S stabilisation in some but not all starvation conditions [1].	21.80	21.80	22.10	22.60	20.80	21.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.87	0.72	-3.60	8	516	2009-01-15 18:05:59	2008-07-02 10:59:42	4	2	476	0	39	130	0	84.70	75	97.83	CHANGED	MKNLIucLLsKLAcKEtEuKpLsAQVEALEllloAlLpsh.csss.pcLIcsVEpAlssApssssss.+.DoElLpp.lp+LLphsps	......MKNLIAELLhKLAQKEEESKELsAQVEALEIIVTAMLRNM...AQN-QQcLI-QVEGALhcVKPD..A..SlPDc.DTELLRsYVKKLL+HPRp...........................	0	1	4	25
+10629	PF10797	YhfT		Protein of unknown function	Mistry J, Coggill P	anon	PRODOM_PD140382	Family	This family is conserved in Firmicutes and Proteobacteria. The function is not known but several members are annotated as being homologues of E coli YhfT, a protein thought to be involved in fatty acid oxidation.	25.00	25.00	79.40	79.30	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.30	0.70	-5.63	13	324	2009-01-15 18:05:59	2008-07-03 11:56:38	4	2	316	0	28	135	1	424.10	79	98.09	CHANGED	lcIlLlAllGuhuAlLANpulAVFpDGlRPIlPEhlEGpMsR+ELuusuFALShGhVhGFGIPhoLusuIllsH.lhLsTDIIGlhssssh....lAullGulaGlhllhuLpsVlslFstLPVNFlsuLuplGsPVlsAFAlFPAlAluYQFGhKpGllshllshluRllls...+at.h.hu.s.....lsLsPEGIulllGMlhLlhaAh+c+hs-css.........ushsolFs-RlpRIpKNhhhLulsGAL..lAAsuuhtIlAGsslSltLLAcu............tlspAAlAshsRulGFlPLIATTAlATGVYGssGhTFVFssG.hluPNPhlAuILGAllIhlEVhLLssIu+aL-+aPulRsuu-NIRTAMspllElALLIGGshAupphuPshGFhllsulYlLNEshGRPll+hAsGPVAAIlsGIlhNlLhllGLF	.....IQIIVVACLTGMTSLLAHRSAAVFHDGIRPILPQLIEGYMNRREAGSIAFGLSIGFVASVGISFTLKTGLLNAWLLFLPTDILGVLAINSL...............MAFGLGAIWGVLILTCLLPVNQLLTALPVDVLGSLGELSSPVVSAFALFPLVAIFYQFGWKQSLlAAVVVLMTRVVVV...RY............FPHLNPESIEIFIGMVMLLGIAITHDLRHRDEN.................DIDASGLSVFEERTSRIIKNLPYIAIVGAL..IA..AVASMKIFAGSEVSI.FTLEKAYSAGVTPEQSQTLINQAALAEFMRGLGFVPLIATTALATGVYAVAGFTFVYAVG.YLSPNPMV.....AAVLGAVVISAEVLLLRSIGKWLGRYPSVRNASDNIRNAMNMLMEVALLVGSIFAAIKMAG......YT......G.....FSIAVAIYFLNESLGRPVQKMAAPVVAVMITGILLNVLYWLGLF...........	0	8	13	22
+10630	PF10798	YmgB		Biofilm development protein YmgB/AriR	Pollington J, Finn RD	anon	PRODOM	Family	YmgB is part of the three gene cluster ymgABC which has a role in biofilm development and stability. YmgB represses biofilm formation in rich medium containing glucose, decreases cellular motility and also protects the cell from acid which indicates that YmgB has an important function in acid-resistance [1]. YmgB binds as a dimer to genes which are important for biofilm formation via a ligand. Due to its important function in acid resistance it is also known as AriR (regulator of acid resistance influenced by indole) [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.79	0.72	-4.16	6	700	2009-09-11 05:26:58	2008-07-28 14:30:18	3	1	416	2	58	197	0	55.90	43	68.79	CHANGED	tpEuulluslVpplLtossaVoNKsIIhpLI+pLETpsDlVptDlhRpsLElVVtpTsDD..I	.................EptsLGphVspLhpuGcslsNKsIIhpLIppLEoppDhhphDlhRpsLEhVl..TsDDh....................	0	2	6	42
+10631	PF10799	YliH		Biofilm formation protein (YliH/bssR)	Pollington J, Finn RD	anon	PRODOM	Family	YliH is induced in biofilms and is involved in repression of motility in the biofilms [1]. YliH is also known as bssR (regulator of biofilm through signal secreton).	20.40	20.40	20.50	119.10	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.59	0.71	-4.44	4	440	2009-01-15 18:05:59	2008-07-28 14:32:18	3	1	439	0	14	59	1	124.30	86	99.55	CHANGED	MsVDRL+pDLLNKLINARIDLAAYLQLRKAKGYMSVSESDHLRDNhFELsREh+s+A.RLp.HlDtEEhssLR+At-ALAsAAVCLMSGHHDCPTaIAVNADKLENCLToLTLsIpsLpcHuPLpps	...MhVDR.RhDLLN+LIsARlDLAAYlQLRKAKGYMSVSESNHLRDNFFKLNRELHDKSLRLNLHLDQEEWSALHHAEEALATAAVCLMSGHHDCPTVITVNADKLENCLMSLTLSIQSLQKHAMLEKA.....	1	1	1	7
+10632	PF10800	DUF2528		Protein of unknown function (DUF2528) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function. Some of the sequences are annotated as ea10 however the function of this protein is unknown.	22.00	22.00	22.10	31.80	20.00	21.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.29	0.72	-3.63	4	191	2009-01-15 18:05:59	2008-07-28 14:32:53	3	1	157	0	4	72	0	105.50	89	89.24	CHANGED	uacIlV-lDHslLTEEKLsELspFWS-u-hclE+HGs.LpAhLphhAs+hhuhslpp......lSscssaN..ust.EGaPshDGSpGlRls-hDph..F-uDDhcVhtl	.....KASIEIE.IDHDVMTEEKLHQINNFWSDSEYRLN.KHGSV.LN....AVLIMLAQHALL.IAIS..SDLN.....AYGVVCEFDWND.GNGQEGWPPMD....GSEGIRITDIDTSGIFDSDDMTIKA.A.......	1	0	1	2
+10633	PF10801	DUF2537		Protein of unknown function (DUF2537)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.30	20.30	21.10	31.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.04	0.72	-3.88	8	113	2009-01-15 18:05:59	2008-07-28 15:02:40	3	1	112	0	28	72	1	83.60	58	76.69	CHANGED	TPWATGLTVAuFVAAVluVAlVVLolGLhRVHPLLAVGLNlVAVGGLAPTlWGWR+TPVhRWFVLGAAVGVsuAWlALLllAh.G	...sPWATGLsVAuFVAA...VlAVAVVVLSlGLl.R.VHP......LLA......VuLNl.VAVuGLAPTLWuWRRsPVLRWFVLGAAVGVAuuW...lALLsls.............	2	7	20	25
+10634	PF10802	DUF2540		Protein of unknown function (DUF2540)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Methanococcus.	25.00	25.00	82.90	82.80	23.90	19.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.21	0.72	-4.31	12	26	2009-01-15 18:05:59	2008-07-28 15:06:32	3	1	13	1	9	21	0	75.30	39	84.61	CHANGED	phtLhcplDs+slRYaLHKL-sl.splss-lLtcuhcscKpa+poloLo-pEccIlcKYG.KuTNhLlNahIlpppp	.pFtLh+slDsRslRYhLHKlEsl.cpIss-l..Lt+AhcscKpa++olTLo-cEccIlcKaG.KuTNlLlNhhIlppc....	0	1	3	6
+10635	PF10803	GerPB	DUF2539;	Spore germination GerPB	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Family	Members of this family are required for formation of functionally normal spores. They may be involved in the establishment of spore coat structure or permeability [1].	25.50	25.50	25.60	50.80	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.56	0.72	-4.21	7	135	2009-01-15 18:05:59	2008-07-28 15:07:18	3	1	134	0	19	64	0	52.40	69	75.89	CHANGED	MNFYlpQoIpINhlRltuloNSSVhQIGSAGSIKsLSpLYNTGuasEPAP.ssus	...MNFYlNQSIhINpl+I-SITsSSVFQIGTAGSIKuLSKFSNTGGFTEPhRPLpAK...	0	4	11	13
+10636	PF10804	DUF2538		Protein of unknown function (DUF2538) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	20.50	20.50	23.80	23.50	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.02	0.71	-4.34	3	217	2009-01-15 18:05:59	2008-07-28 15:07:59	3	1	215	2	10	43	0	153.40	91	99.52	CHANGED	MSRKTYEKlANINGMFNVLEQQIIHSKDMALFRSEFFYVNHEHRENYEALLIYYK-SslNPIVDGACYILALPEIFNKVDVFESELPFSWVYDENGITETMKSISVPLQYLIAAALEVTDVNLFKPSGFTMGMNNWNIAQMRIFWQYTAIVRKEAL	....MSRKTYEKIANINGMFNMLEQQIIHSQDMAHFRSEFFYVNHEHRENYEALLIYYKNSIDNPIVDGACYILALPEIFNSVDVFESELPFSWVYDENGITETMKSLSIPLQYLVAAALEVTDVNIFKPSG...FTMGMNNWNIAQMRIFWQYTAIIRKEAL..............................................	1	3	4	10
+10637	PF10805	DUF2730		Protein of unknown function (DUF2730)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.24	0.72	-4.30	11	133	2009-09-10 19:13:11	2008-07-28 15:08:36	3	1	124	0	31	115	5	98.70	21	91.33	CHANGED	hh.hlpspWsl.lhulhshssshhhhhhsppYA++c-ltpL.......-pRLsphEs+lcsLPTpp-VpcLclplscl+G-hKshssslpsloHQscLLLEpcL..pcc	............................................................t.ash.lhshh...hsshhhhhh.pp.p.a.sp.ccchpp...............L..............................cpRlsp.lEsclpslPspp-lpcLplplsplcG-l+slsspl....psl....s+..pLLlEptl.....pt..................................	0	10	22	26
+10638	PF10806	DUF2731		Protein of unknown function (DUF2731)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	21.40	21.40	21.40	22.30	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.71	0.71	-3.87	11	76	2009-01-15 18:05:59	2008-07-28 15:10:58	3	4	74	0	52	74	0	94.50	29	29.59	CHANGED	hpVPsPlKplFDsFPLpsY..tslsppcsus.pslpp+pahF..............sssssp.sssssFpLGVaNVhphptst.....shLsoDPhuLhspLhLC+KNsLtLPo.........tsss...................spsssslhhLShhAusDppLPILlE	..hsVPsPlK+lFDpFPLhTY..ss.sttspshttp..hpp.+hasF..............ts.t.t.t.....................................................................................................................................................................	0	7	22	41
+10639	PF10807	DUF2541		Protein of unknown function (DUF2541)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. All proteins are annotated as YaaI precursor however currently no function is known.	21.90	21.90	24.00	23.70	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-4.39	2	436	2009-01-15 18:05:59	2008-07-28 15:11:09	3	1	433	0	6	84	0	132.60	88	99.68	CHANGED	M+SlhplSVGLlhGluh.osAtANDHKILGVIAMPRNETNDLsLplPVCRlVKRIQLoAD+GDlpLSGAoVYFKsuRuASpoLNVPuuIKEGpTTGWININSDNDsKRCVpKIsFSGHTVpSSDMApLKlIGDD	.............MKSVhTISASLA...I.S.LML.CCTAQANDHKILGVIAMPRNETNDLALKLPVCRIVKR...IQLSADHGDLQLSGASVYFKAARSASQSLNIPSEIKEGQTTDWININSDNDNKRCVSKITFSGHTVNSS.DMATLKIIGDD........	0	1	2	4
+10640	PF10808	DUF2542		Protein of unknown function (DUF2542) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.	25.00	25.00	57.30	57.20	22.20	22.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.75	0.72	-3.71	3	411	2009-01-15 18:05:59	2008-07-28 15:46:52	3	1	410	0	6	41	0	78.50	81	99.60	CHANGED	MDVQTIFVVlAFLLlPLFCFREAWKGWRoGAVDKlVKNAREPVYVYRAcsPlLYWSYlsLYlGhGlLolGMIIYLLFYR	MDVQQFFVVAVFFLIPIFCFREAWKGWRAGAIDKRVKNAPEPVYVWRAKNPGLFFAYMVAYIGFGILSIGMIVYLIFYR.	0	1	1	4
+10641	PF10809	DUF2732		Protein of unknown function (DUF2732)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	25.40	25.30	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.57	0.72	-4.43	8	350	2009-01-15 18:05:59	2008-07-28 15:49:26	3	1	279	0	29	161	1	73.20	45	96.25	CHANGED	M+NschtoTpous--shLspLLs-ARhEERKsRAhAlShRL-ALAlHIsp+phousEAAELLR+EAs+aEsESQ.ElH	......................................t....hslLLspARhEERpspApthuuRLDuLAsHITpcpLs+VEhsELLRppAEphpNput.-........	0	0	7	21
+10642	PF10810	DUF2545		Protein of unknown function (DUF2545)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function is restricted to Enterobacteriaceae. The sequence is highly conserved.	25.00	25.00	68.60	68.50	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.95	0.72	-3.58	2	416	2009-01-15 18:05:59	2008-07-28 15:50:10	3	1	412	0	5	40	0	79.40	86	99.91	CHANGED	MIYLWhFLAlsIlsVSGYIGQVhshhSAlSSFhGMVILAALIYhhshWLpsGs-lVoGlhhFLAPACGLhIRFMVGYG+R	....MIYLWMFLALCIVCVSGYIGQVLNsVSAVSSFFGMVILAALIYYFTMWLTGGNELVTGIFMFLAPACGLMIRFMVGYGRR..	0	1	1	3
+10643	PF10811	DUF2532		Protein of unknown function (DUF2532)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	280.50	280.30	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.04	0.71	-4.42	11	41	2009-01-15 18:05:59	2008-07-28 15:51:57	3	1	41	0	6	23	0	158.00	85	95.55	CHANGED	KLIhCFLILVSAVKVNADFNsIQDNFEYQE...EQLsIELPWSDCTEIHKLLEEKLSFSEQQIKKENKI+EKYKQFYLKHNNP.oNFSMQFLEKKSETNGVETLISGFLKFCEDNFQTSKSKSNSLNYaIKKQQDQWaNsIRNENYKIYYRKKY-DNIhRNN	.KLITCFLILVSAVKVNADFNNIQDNFEYQE...EQLhIELPWSDCTEIHKLLEEKLSFSEQQIKKENKI+EKYKQFYLKHNNP.TNFSMQFLEKKSETNGVETLISGFLKFCEDNFQTSKSKSNSLNYYIKKQQDQWFNDIRNENYKIYYRKKYEDNIFRNN..	0	1	1	1
+10644	PF10812	DUF2561		Protein of unknown function (DUF2561)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacterium spp.	20.50	20.50	20.60	21.10	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.42	0.70	-4.72	7	80	2009-01-15 18:05:59	2008-07-28 15:52:41	3	2	78	0	14	39	1	203.10	60	94.39	CHANGED	Mss.p.SAhRc..GsD.shu.-slDRILlGACAAlWLshlGsuVAAsVALhDLGRGapphuusscTsWVLYuVIsVSALlIsuAlPlLLRARRhAcsEPsspshshscpsut..shtsutssspstpcpss....ssuht.ssth.............sstAVDRlWLRsTlslsushGsAhlAVusATYLMAVG+DsASWVuYGLAGlVTsuMPsl.WhalRpLRt	..............MVS.RYSAYRR..GPD.sISPDVIDRILlGACAAVWLVFsGVSVAAAVALhDLGRGFHEhAGsPH.TTWVLYAVIVVSALVIVGAIPVLLRARR..MAEAE..P...As.RP....oGA....u.s..RGGc......oluSGpPA...tRAsA..E.SAP...VpHAcAh..csAAEW...............................SSEAVDRIWLRGTVVLToAIGIALIAVAAATYLMAVGHDGsSWluYGLAGVVTAGMPVIEWLYsRQLRR..................................................	2	1	8	12
+10645	PF10813	DUF2733		Protein of unknown function (DUF2733)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	21.20	21.20	22.60	25.70	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.92	0.72	-7.29	0.72	-4.39	12	28	2009-01-15 18:05:59	2008-07-28 15:54:04	3	1	27	0	0	22	0	32.40	43	45.92	CHANGED	MGs.lhSlC+RRhsPlhDVcGp.IsltcDFE.h	..........MGh.lhSlC+RppNslhDVcGp.IslscDFE.h..	0	0	0	0
+10646	PF10814	DUF2562		Protein of unknown function (DUF2562)	Pollington J, Finn RD	anon	PRODOM	Family	This protein of unknown function appears to be restricted to Mycobacterium spp.	25.00	25.00	26.90	25.80	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.75	0.71	-4.21	7	75	2009-01-15 18:05:59	2008-07-28 15:54:39	3	2	75	0	13	36	0	131.90	70	92.93	CHANGED	LTPRpRLoRGLpYosVGPVDVTRGl....lGLGlcSApSTAutLRRRYppG+LAR....ELAAApEsls.ElAAAQEVVAsLPpslQcA.....Rpt+RR.+RPhllAG.VAVsVLAGGAVsFSIVRRSsp...PEPSPhPPSVEVpP+P	.......LTPRERLTRGLuYSAVGPVDVTRGL....VGLGLQSARS...TAAuLRRRYREGR....LAR....EVAAA.QETLAQELsAAQDVVANLPQALQDA........RTpRRs+++hWIFAG.IA........A.Al.LAGGAVAFSIVRR.SSR...PEP.SPRPPSVEVQPRP............	0	2	7	11
+10647	PF10815	ComZ		ComZ	Pollington J, Finn RD	anon	PRODOM	Family	ComZ is part of a two gene operon. It affects competence regulation by negatively affecting the transcription of the ComG operon. ComZ contains a leucine zipper motif [1].	21.00	21.00	21.10	21.60	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.67	0.72	-4.19	7	116	2009-01-15 18:05:59	2008-07-28 16:00:15	3	1	115	0	14	41	0	55.40	79	83.53	CHANGED	EKoMcFhQIAMKalPEAKt.L-csGI-LohEhlQPhhsLhhpVMsEAYELG+sDAp	......EKSMQFLQIAMKHLPE.AKAILDDNGIALDMEKAQPVLELLMKVMNEAYELGKADpE....	0	3	8	10
+10648	PF10816	DUF2760		Domain of unknown function (DUF2760)	Gunasekaran P, Mistry J	anon	Pfam-B_001564 (release 23.0)	Domain	This is a bacterial family of uncharacterised proteins.	25.00	25.00	116.20	116.10	19.50	18.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.49	0.71	-4.62	29	227	2009-09-11 06:04:09	2008-07-28 16:01:46	3	1	225	0	68	201	15	125.90	59	60.21	CHANGED	psossuALQLLuLLQ+EARhIDFlpEDluuaoDA-lGAAARllHpGC+KlLp-aFolpPVRsE.....sEGoRlolstGFDusplRLTGNVsGpuPFsGsLhH+GW+sscV+LPKlusspDs...s.llAPAEVE	.......sAosDuALQLLuLLQ+EARLIDFlpEDlusaSDtElGAAARVlHsGspKVLcEahTLsPlRsE.....pEtoRloltsGFssppIRLTGNVsGpAPFsGTLlH+GW+ssslpLPKLu-saD.s....o..llAPAEVE.	0	23	34	55
+10649	PF10817	DUF2563		Protein of unknown function (DUF2563)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacterium.	21.20	21.20	21.50	22.50	19.50	21.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.33	0.72	-3.59	3	55	2012-10-01 21:44:22	2008-07-28 16:02:45	3	1	51	0	6	23	0	102.30	73	98.01	CHANGED	MFVDT-LLHSGGNESHRAGGHA+-GADQLAtGPLhSGMFGDFAAADAFHsAVsuAHAQHVRNLQAHpEALTuVGoKAHHAAsGFTsMDspNAsEL+AVRsSuuT	.......MFVDVGLLHSGANESHYAGEHAHGGADQLSRGPLLSGMFGT.FPVAQTFHDAVGAAHAQQMRNLHAH.RQALITVGEKARHAATGFTDMDDGNAAELKAVVCSCAT.................................	0	1	3	5
+10650	PF10818	DUF2547		Protein of unknown function (DUF2547)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	23.10	23.10	23.80	46.00	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.36	0.72	-3.36	8	80	2009-01-15 18:05:59	2008-07-28 16:03:26	3	1	79	0	11	55	0	95.20	43	92.21	CHANGED	KpsFWSQLLhShIAIFALPpsQshphtp....sNcs.QsollpQplsp.ssplspclpQQshaltph.h...t.hpIpPp......Fhssshpap....sPIRAGPhs	....KssFWSpLLLullAIFALPsuQuhp.ps.....ssEN.psol..Q..QhLp.slplsc-spp.Qs.h..sphshpsct.hphpPH......Fhscshshs....APIRAGPl.h	0	1	4	10
+10651	PF10819	DUF2564		Protein of unknown function (DUF2564)     	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	59.20	58.90	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.61	0.72	-3.86	7	123	2009-01-15 18:05:59	2008-07-28 16:06:46	3	1	123	0	17	47	0	78.60	67	93.60	CHANGED	GasDh+QlEhAVETAQKhsGtAT+uhssshlcsAhQAlEsAR.Qhspupphts.lDp.sFltpppplLscspHQLcEucc	.tVNDFEEVKFRVETAQKMVGSATISMDPDTLEHATTAVEAARSQLEIMKSVATDLDE.PFLMNEEKKLs+CEHQLsEA+H.....	0	3	9	11
+10652	PF10820	DUF2543		Protein of unknown function (DUF2543)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.	25.00	25.00	103.90	103.70	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.60	0.72	-3.97	5	335	2009-01-15 18:05:59	2008-07-28 16:07:32	3	1	334	0	14	60	1	80.80	93	99.94	CHANGED	MoNDIPLKYYDIADEYuTEoApPVSDuER-sLAHYFQLLITRLMNNEEISEEAQ+EMAsEAGIsEsRIDEIAsFLNQWGNE	MNHDIPLKYFDIADEYATECAEPVA-AERTPLAHYFQLLLTRLMNNEEISEEAQHEMAAEAGINPVRIDEIAEFLNQWGNE.......	0	1	2	8
+10653	PF10821	DUF2567		Protein of unknown function (DUF2567)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.16	0.71	-4.73	19	131	2009-09-11 10:54:39	2008-07-28 16:08:36	3	1	131	0	34	108	0	156.80	42	71.54	CHANGED	GLuusGsLlGuLWAWlAPPIHuVVAlTRuG-RV+tYLGuESppFFsAshhhlGLLSVLAVVAuVhhWQ.WRpHRGPhhVAuLuhGhssAAulAAGVGAhlV+LRYGulDhsssPlop.-+slsYVspAPPVFFu+pPLQIAhTLhaPAulAuLVYAlhAAuTuRDDLGG	.........................GlussGlllGu.LWAalAPPl+u.VVs..hTRsGpplhtaL.G.uES.ppaFh.As.hhhlGLhsVluVVAuslh.Wp.hR.c+RGP.hVuuLulGhssAAu.lAA.uVGuhls+hRYus.....lDhsssPlst..sttls..hVspA..PPlaa...uctslph....Ahs.Lhhs.sslA.uLVYulhAuusuRDDLGs.................................................	0	7	23	30
+10655	PF10823	DUF2568		Protein of unknown function (DUF2568)	Pollington J, Finn RD	anon	PRODOM	Family	One member in this family is annotated as yrdB which is part of a four gene operon however currently no function is known.	21.10	21.10	25.00	24.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.20	0.72	-3.76	12	114	2009-09-14 14:03:47	2008-07-28 16:14:56	3	1	105	0	44	113	0	90.70	29	80.50	CHANGED	lhlRFlLELsslsuluhaGaphs.shhh+hslulshP...llhhllWuhFtuPpusp+.......lpGhsRhhlElllFuhushAhhhssp.hhulsaAslhll	............sltFlLELssLssluh....aGaphs...ts......hh....h+hslulhhP...llssllWGhFsAP+.uthp.......l.shh+lhlElhlFus.ushu.lhhhsphhhuhhhuhlhh...................	0	13	33	38
+10656	PF10824	DUF2580		Protein of unknown function (DUF2580)	Pollington J, Finn RD	anon	PRODOM	Domain	This family of proteins with unknown function appears to be mainly found in actinobacteria.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.06	0.72	-3.66	56	605	2012-10-01 21:44:22	2008-07-28 16:17:35	3	2	159	0	185	723	2	97.70	19	80.66	CHANGED	Mo....spLpVpPstL+phAupHspsAsplss...ussus..uhssplttoHGslsuphpsshpthhssRpsshsphtssssclApsLcsAAuhYppsDcssupslcs	................................lpVssstLcshA...up...hsphAsplss.......sssss........st.ss..t.s.ssshG.......h..s..s..t..hs.ss.hp.t...hhst.t....p...s...shsph....s...sshsshApsLpsuAstYppsDpssuttlt.t........................	0	51	128	167
+10657	PF10825	DUF2752		Protein of unknown function (DUF2752)	Gunasekaran P, Mistry J	anon	Pfam-B_001601 (release 23.0)	Family	This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	20.90	20.90	20.90	20.90	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.45	0.72	-3.94	79	584	2009-01-15 18:05:59	2008-07-28 16:18:56	3	1	475	0	185	535	65	51.50	32	38.74	CHANGED	sCPh+tlTGh..CPGCGhpRuhhsLl+G-lsuAhphNshhhsshshlhhhhhh	................sC.h+tlT.Gh..CPGCGspRuhhsL.lHG-lsuAhphNshhlhs.h.shhshhhh.h..............................	0	71	142	172
+10658	PF10826	DUF2551		Protein of unknown function (DUF2551) 	Pollington J, Finn RD	anon	PRODOM	Family	This Archaeal family of proteins has no known function.	21.70	21.70	22.10	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.80	0.72	-4.08	12	39	2009-01-15 18:05:59	2008-07-28 16:20:34	3	1	26	0	36	39	0	81.70	41	78.54	CHANGED	LcpYLpRDpsGlR+slLplFLcscphThs-la-tLpcc.FsVSh+uVuuMVGllsS+LGILps..sshGspslYpLKEcYtslV	...LpcYLpRDpsGlR+slLplFLcscphTss-lach.Lpcc.FslSh+uVuuMVGlhsS+LGILps..pshsspshYpLKEcYtslV...........	0	7	28	32
+10659	PF10827	DUF2552		Protein of unknown function (DUF2552) 	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.70	21.70	21.80	117.40	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.79	0.72	-4.05	5	119	2009-01-15 18:05:59	2008-07-28 16:21:31	3	1	119	0	13	32	0	78.80	78	98.21	CHANGED	M-QKLKsL+NTAQNKTWVSFLNpNHPYTLLHWSIGGs-SlKKDVWLLQDEMTFETcEFPTLEpAIsWIuENM-pITDVL	.MDKQL+TLRNIANERTWASFLNDNHPYSLLHWSIAGVGQEuKDVWLLQDEVTFQTTEFPTLD-AhpWISENMEQVTDVL	0	1	5	7
+10660	PF10828	DUF2570		Protein of unknown function (DUF2570)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteins with unknown function.	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.48	0.72	-4.46	7	240	2009-01-15 18:05:59	2008-07-28 16:22:39	3	2	193	0	18	152	10	105.20	32	83.99	CHANGED	h.palhu...slshl..ILGLsuWhWhQSppIsoL+AENpsQAQTIppQpcANppLs.tLpQERQAV.tQQchsNElcptsppstEplKoIltppsCA+scLPpuVlD...RLHp	.............................hh..ha.hlul.uhl...llu...hhGh....h.phS..as.lu+.pAc....scsQspTlcspscs...h...shl.......ss.....ulQ........ph......pplltp.ptpsQ.Qhp.p.-....u-.tppE....pl+ssIucDc.CA+s.LPsu..........+ht..................................	1	1	4	12
+10661	PF10829	DUF2554		Protein of unknown function (DUF2554)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	76.00	75.90	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.73	0.72	-3.88	3	416	2009-01-15 18:05:59	2008-07-28 16:23:53	3	1	410	0	11	60	0	67.60	84	99.76	CHANGED	MlTKsLSVVLLTCALFSGQLMAGHpGHEFVWVKNVDHQLRHEADSDELRAVAEESAEGLREHHNWQKSRKPEoaFR	.MhpKslSslLLsCALFSGQLhAtppGH-FVWVKNVDHQLRHEADSDELRAVAEESAEGLREHFYWQKSRKPEAGQR...	0	1	1	5
+10662	PF10830	DUF2553		Protein of unknown function (DUF2553)	Pollington J, Finn RD	anon	PRODOM	Family	This family of bacterial proteins has no known function.	20.70	20.70	21.00	54.20	20.10	20.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.70	0.72	-3.46	8	101	2009-01-15 18:05:59	2008-07-28 16:24:25	3	1	101	0	15	44	0	73.00	59	92.91	CHANGED	pp+lDIT-+VTGRhcsGpLsLYc-NEhIGc..Msuts.QYELKsGYoacspKFY+hsDsssps-tKYVD.CD.EsGWC	.o.hKIDITN+VluKF.+.sshLELYpsc.MIGKFYVYTEsKQYVLEDGYlYEsGKFYRIID.THR.GNspsAEuCD..LGWC...	1	2	9	10
+10663	PF10831	DUF2556		Protein of unknown function (DUF2556)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	71.90	71.60	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.85	0.72	-4.33	3	414	2009-01-15 18:05:59	2008-07-28 16:24:39	3	1	413	0	10	45	1	45.60	92	88.54	CHANGED	MIRKYWWLVVFAVSVFLFDALLMQWIELLoTETDKCRNMNSVNPLKLVNCoDL	MIRKYWWLVVFAV.VFLFDsLLMQWIELLATETDKCRNMNSVNPLKLVNCDEL	0	1	1	6
+10664	PF10832	DUF2559		Protein of unknown function (DUF2559)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appear to be restricted to Enterobacteriaceae. The sequences are annotated as yhfG however currently no function is known.	20.50	20.50	20.60	20.50	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.81	0.72	-4.17	3	338	2009-01-15 18:05:59	2008-07-28 16:27:31	3	2	335	0	17	58	0	53.80	83	95.45	CHANGED	KKLTDKQKSRLWEtQRNpNFQASRRLEGVEVPLVTLTAEEALARLEELRRHYER	...KKLTDKQKSRLWE.pRNtNFQASRRLEGVEhPLVTLTAsEALARL-ELRRHYER......................	0	1	2	10
+10665	PF10833	DUF2572		Protein of unknown function (DUF2572)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.30	20.30	21.20	20.70	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.48	0.70	-4.93	5	87	2009-01-15 18:05:59	2008-07-28 16:28:22	3	2	84	0	12	71	0	200.60	36	82.57	CHANGED	KGllTLTILhLLSulLlIhMLFDDDtL+aHpSlhuQRKlYVpQsLpLQ+hopEQKpslCpcl....PLNoopssppIoFcptutsDu...puaFlWCcRpoLFKppPKKuhNpGuLSpaINcEpluLFpH+FpusPt.Lsss+usYLYWlD-sQsElpIsGsIsAIlIAEGDLKIsGKGRI+GsVITGGsLoLE.uVpluY+KtTVssLVppYSpWQLAEKSWaDFss	...................................................................................................+GhhTLslLlhlSulLslhhLhcDshLphaputtsQRphYVppplpL.chotpccpptC.pl....shspstpshplsh.t..Lp..t...s-u...lpaalWCcR.sLF.p.p.pPp+st.p...s..tlppFls.t..p..tl...shFp..phu..psP.t....sspp.PplYWhss.sps-hplsts..lpul..lIAEGDLclpGpG+IpGslITsGpLoL-..s..l.plsYuKpsVstllppYSpWplAEpSW.DF.........	0	1	5	11
+10666	PF10834	DUF2560		Protein of unknown function (DUF2560)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	42.00	48.60	23.00	20.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.60	0.72	-4.02	2	125	2009-01-15 18:05:59	2008-07-28 16:28:58	3	1	115	0	8	42	0	78.70	72	95.74	CHANGED	MAEIhshTE.QphpL-Ih+LV.spsAAAEcAhtFlusscLphELFK.ph..utupushhsRs.EAlRcuKEALDLFTsGA	...MAEIIPMTEEQKFQLEIYKLVMNQNAAAEEAFQFIGTDELKLELFKIHFQSG.GANSDITTRTIEAVRKSKEALDLFTTGA......	0	0	0	0
+10667	PF10835	DUF2573		Protein of unknown function (DUF2573)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this bacterial family of proteins are annotated as YusU however no function is currently known. This family of proteins appears to be restricted to Bacillus spp.	22.80	22.80	23.00	80.70	22.40	22.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.75	0.72	-3.94	7	119	2009-01-15 18:05:59	2008-07-28 16:29:26	3	1	119	0	11	45	0	80.30	77	97.34	CHANGED	tpKhcEQlDGLlEKYTELLLGEos-EhKEcVKtWllYSHIAKSMPPLAKHWNusYP-AK-tlKclIpcIKcLNEt+R..psK	....S.EKFNEQFDGLLEKYTELLLGESNEERKEQVQKWALYSYIAKTMPALVKHWNET..YPDAKEEMVQLITcIK+LNEEKRNE...Q..	0	4	7	8
+10668	PF10836	DUF2574		Protein of unknown function (DUF2574)  	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appears to be restricted to Enterobacteriaceae. Members of the family are annotated as yehE however currently no function is known.	25.20	25.20	26.30	48.90	23.80	25.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.03	0.72	-4.28	4	385	2009-01-15 18:05:59	2008-07-28 16:30:48	3	1	383	0	7	60	0	75.30	65	99.38	CHANGED	MpKYhL.GIIhLAYGluSPsFuSDTATLTIsG+losPTCSh-VVNsQLQQRCGphhahssspppASoPs+GVTTEVlslsusSpRpIVLNRYD	........................................hthVNuQsQQ+CGQLhasVDTpa.sSSPsKGVTTEVVsssuDSKR+IVLNRYD.....	0	1	1	3
+10669	PF10837	DUF2575		Protein of unknown function (DUF2575)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appears to be restricted to Enterobacteriaceae. Members in the family are annotated as yaaY but currently there is no known function.	25.00	25.00	29.70	29.70	19.40	17.80	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.47	0.72	-3.88	2	193	2009-01-15 18:05:59	2008-07-28 16:31:56	3	1	192	0	4	26	0	68.10	82	99.23	CHANGED	hpHSLRSDGAGFYQLAsCEYShShhKIAhuGtFhsslCpMAMKShFFhhp.hNRRLTLTAVQGILhRFSLF	................hpHSLRSDGAGFYQLAsCEYShShRKIAhuGtFhsslCtM..AMKShFFhhs.hNpRLTLTAVQGILhRFSLF.........	0	1	1	3
+10670	PF10838	DUF2677		Protein of unknown function (DUF2677)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as UL121 however currently no function is known.	20.90	20.90	21.00	31.50	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.06	0.71	-4.59	4	34	2009-01-15 18:05:59	2008-07-28 16:32:48	3	1	14	0	0	29	0	163.10	63	91.10	CHANGED	hsllh.sstGstss.hCssspsplKlpChL.pLDpRLaW.lpDop....RVhsFc.-spp.hs...........apV-VRtsh.ssp.asl.LhhPLh.psTVuLLL.DhtpsR.EclLChuhlPph+tlpsCthDsDLulLYuVCllLSlSlVsAulhKlDYDpoht..hpuYKS	..............LMChALMARGTaGAYICSPNPGRLRISCALSV..LDQRLWWEIQYSSGRLTRVLVFH.DsGEcGDD.........LHLTDTRHCTSCTHPYVISLV.TPLTINATLRLLIRDGMYGR.GEKELCIAHLPTLRDIRTCRVDADLGLLYAVCLILSFSIVAAALWKVDYDRSVAVssKSYKS.....	0	0	0	0
+10671	PF10839	DUF2647		Protein of unknown function (DUF2647)   	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins are annotated as ycf68 but have no known function.	22.30	22.30	23.70	26.30	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.46	0.72	-3.90	4	31	2009-01-15 18:05:59	2008-07-28 16:33:42	3	1	25	0	6	19	0	67.80	65	51.29	CHANGED	AYSSCLsRohhssKLLLRRIDGAIQVRSpVD.TFYSLVGSGRSGGsP.....susLhpp.aIsh.sh.uhLStst	..............AYSSCLNRSLKPNKLLLRRIDGAIQVRSHVDhTFYSLVGSGRSGGGs......st.L.SR.pIp.lSVautLShpp....................	0	0	0	2
+10672	PF10840	DUF2645		Protein of unknown function (DUF2645)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YjeO however no function for this protein is currently known.	25.00	25.00	26.10	25.70	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.53	0.72	-3.86	5	170	2009-01-15 18:05:59	2008-07-28 16:39:21	3	1	157	0	19	68	0	99.80	65	98.68	CHANGED	MS.+htlLsthYhIlChLhIhlhSsLDcEaMIDGp-IsNlC-VhRtl.sDDoRDFsuhhsLPLhhPFFasslh++hKShFLsllullLluYWlWpFFIRapFC	........Ms.pMFlLCCIWFIVAFLWIsITSuLDKEWMIDGRGINNVCDVLhYLEpDDTRDV.GVIMTL.PLF.FPFLWFA.....LWR.....KK.RGWFMYATA....LA.IFGYWLWQFFLRYQFC....	0	1	8	10
+10673	PF10841	DUF2644		Protein of unknown function (DUF2644)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Pasteurellaceae.	20.90	20.90	20.90	23.00	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.96	0.72	-3.94	10	46	2009-01-15 18:05:59	2008-07-28 16:40:06	3	1	38	0	8	46	0	58.90	55	70.91	CHANGED	pELITNsDGRLSTTuFIQFaGALlMAGILlYuVaLDRsYVsELFssFAlFCG.GusATKGh	..ELlTNs.DGRLSTTuFIQFFGhLlMAuILhauVYLDRshVs-LFhsFAhFCu.GusATKGh..........	0	1	6	8
+10674	PF10842	DUF2642		Protein of unknown function (DUF2642)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillus spp.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.09	0.72	-4.48	10	100	2009-01-15 18:05:59	2008-07-28 16:40:24	3	1	82	0	24	81	1	61.00	45	78.44	CHANGED	uPQlVSllDPYVYQTLQollGcclVVpTlRGolRGpL+DVKPDHlllEus.pslaaIRlQQIVhVhP	............phluhssPYVhpslppllGpplVlET.VRGsl.+G.pLcDVKPDHl.llE.s....sssahlRlpQIValhP..........	0	8	18	18
+10675	PF10843	DUF2578		Protein of unknown function (DUF2578)	Pollington J, Finn RD	anon	PRODOM	Family	This is a Saccharomycete family of proteins with unknown function. The protein in S. cerevisiae is strongly induced in response to many stress conditions and is repressed in drug resistant yeast strains.	25.00	25.00	144.70	143.00	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.33	0.71	-4.63	12	62	2009-01-15 18:05:59	2008-07-28 16:41:18	3	1	42	1	37	43	0	168.30	55	97.50	CHANGED	Mo.KKcKp.....................PKspohohpSsES...............lKsFEDLpsFEsFl+sET..Ds-FDahHs+LpYYPPFVL+EsH--.EKIKsTsNp+SKKFhRcLppHlcKHLlKDlccshth.-L+FcctucpEoFs+lsW+atDpo-a.........asR+a+lplsVoCpp-sAMVDVDYKohP	..........................hpc.........................pKtPKhpTloTcsGEo...............lKVFEDLpsFETal+sETE.D.s.-FDalHC+LpYYPPFVLH-uH-.DPEKIK-TsNSHSKKFVRHLHQHlEKHLLKDIKpAlshPELKF+-KsKcEoF-.+......IsW+Ys-ET-a.........asR+FKlpVpVsCsH-sAMV-VDYKThP..	0	4	18	31
+10676	PF10844	DUF2577		Protein of unknown function (DUF2577)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function	21.50	21.50	21.90	24.40	21.40	20.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.26	0.72	-3.96	46	176	2009-01-15 18:05:59	2008-07-28 16:41:52	3	2	132	0	36	161	2	103.90	26	92.34	CHANGED	chlcphutsshpsspPspl..hhGpVlossP.Lplplsp..p.llLspc...Lhlsc.hlpchphphphpt..tp....................................................hhhpssLchGDcVlllp...psG.QpalllD+l	...............hlpthuhpuhpsspPspl..hhGcVhossP.Lcl.plsp..p..llLsp-.....lllsc.plpphphphphpt...t................................................................h.h.ssLcsGDpVhllp......hpuG.QpahllD+l...................	0	18	30	31
+10677	PF10845	DUF2576		Protein of unknown function (DUF2576)	Pollington J, Finn RD	anon	PRODOM	Family	The function of this viral family of proteins is unknown.	20.40	20.40	20.60	21.50	19.80	17.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.47	0.72	-4.80	13	18	2009-01-15 18:05:59	2008-07-28 16:43:07	3	2	17	0	1	15	0	44.90	69	27.79	CHANGED	NAPVVsSpHDYDR-QI+RELNSLRRsVH-LCTRS.uTuFDCN+FLcSsD	....NAsVVsotpDYDR-Ql+RELNSLRRsVH-LCTRS.uTuFD.CN+FLcSsD..	1	0	0	1
+10678	PF10846	DUF2722		Protein of unknown function (DUF2722)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	21.00	21.00	21.10	21.70	20.20	20.90	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.57	0.70	-5.44	11	93	2009-01-15 18:05:59	2008-07-28 16:44:51	3	2	76	0	69	95	0	283.10	20	67.85	CHANGED	M................poh.t..p..pphsspspsppppp...............................................................................................................suL.sLLGsNVssaPaSEsuhlculcL+sEQE+TKQpYYKLEssNKslpllcpAlpApIPsNhIPhLa..h.Nss.......................................................................................pspspspsss.spss.spssusshlsspp.s.............psPhsY+Fsssosss.............p.h..sspRRshSPA+IGAu.....AVAsLusssssh+............ptsssshR+...p.spsHpRphShPs................................ptspsssp.ps........................sTSslphps.sspslp+pstssspssp-.hToh.Hhl....h+.t.......................................p.p+cH.....+Rp+Ss.othtsIDLs..s.......t...............p.scss-ssp+pppspppps.......s....................................-Dpsho.soSh....................spsssposht+hPpsls..ph.N.s	..............................................................th...........................................................................................................................................................................................ph+.EpE+T+Qphh+LEptphph-lL+huhpuGlPsshIPhlF....hsssst.hs.t............................................................................................................................................................tp.t..tpttp.tpp..th.tss....t..p..............................s..hth.s......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ss......................................................................................	0	9	34	60
+10679	PF10847	DUF2656		Protein of unknown function (DUF2656)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	23.00	23.00	23.60	23.00	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.64	0.71	-4.23	12	19	2009-09-16 17:37:28	2008-07-28 16:45:57	3	1	18	0	8	18	18	129.70	41	90.86	CHANGED	hFlLSHNLQlpSshVPulusp-LApGL...hupustlpsspsLsHPHWhVclc...SsLSsp-hAp-LVcuWcphRpsh..GHshsHslLALGGRKDot.usPGuP..LQpGpWGVDVVEssss-sFLpuINW-ALKuGRPsD	.........hhlLSHNhplpss.VPslshp-lApsl...hsppstlpsspslsHPHWhVclp.....ushSspchupthsp.uWpphRpuh....ucshsHslLALGGRKDos.ussuuP..LQpGtWGVDVVETsss-sFLpuINW-uLpuGRPtD.......................	0	2	3	6
+10680	PF10848	DUF2655		Protein of unknown function (DUF2655)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	41.10	40.60	21.30	16.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.96	0.72	-4.12	2	140	2009-01-15 18:05:59	2008-07-28 16:47:03	3	1	139	0	2	13	2	81.30	87	84.83	CHANGED	hSVAphShGpTAQLStKQsGaYSPEhh.STGKDCNPQPANCLKsQYVLRHCCVDDRSsKMGYSsKhhVLTphssETASLFHC	.....MSVAphShGpTAQLStKQsGaYSPEhh.STGKDCNPQPANCLKsQYVLRHCCVDDRSsKMGYSsKhhVLTphssETASLFHC.	0	1	1	1
+10681	PF10849	DUF2654		Protein of unknown function (DUF2654)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as a-gt.4 however currently no function is known.	25.00	25.00	73.00	72.40	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.42	0.72	-4.24	13	35	2009-01-15 18:05:59	2008-07-28 16:48:29	3	1	34	0	0	26	0	70.20	49	63.06	CHANGED	AcKKApKhL+KNpREIcRL++HAEpAlhssN+-tYhYAIpKLRsIhKQ.Phsc-llpshWhToRpQlh-hl	...Ap++AsKlL+KNpREIpRLp+HAptAlhsNNhstYtYAIpKLRcIhKQ.Phs-ELlphhWpToRpQI.-hl.......	0	0	0	0
+10682	PF10850	DUF2653		Protein of unknown function (DUF2653)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	21.60	21.60	23.10	47.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.03	0.72	-3.68	4	127	2009-01-15 18:05:59	2008-07-28 16:49:31	3	1	127	0	16	75	0	81.40	66	89.06	CHANGED	MppI.IsEQ-IIsAlClYIApp+pItPE-V.V.ELhYDDcoGFuAElpsshppp.LhosslIpALR.alc-.hpsNPausslcLpLDcccGIh	.........l..p-llsulClahupcctltPE-V.V.ELMYDDDYGFSAEVEVN.GR.Q.QILIQANLIEALRLLLDREYNVNsFAARLQLELDDEEGIY....	0	5	12	12
+10683	PF10851	DUF2652		Protein of unknown function (DUF2652)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	22.10	22.10	22.60	32.20	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.45	0.71	-4.09	6	72	2009-01-15 18:05:59	2008-07-28 16:50:17	3	1	65	0	15	46	51	104.00	71	46.52	CHANGED	lApLLEuVI-Au.psLKLAKLEGDAAFFaAsssssssh.lscphstMRpuFhpRREphc+D+.CpCcSCtQlcsLSLKFVAHtGEVApQ+VK+psELAGhDVILVHRMLKNpVPVsEY	.......VAQLLESVIDAu.KGhKLAKLEGDAAFFWAPGuNsSVl.VC-RsspMRQ+F+sRREQIKKD+sCDC+SCpQt-sLSlKFVAHpGEVAEQKVKRNVELAGVDVILVHRMLKNEVPVSEY....	0	4	9	13
+10684	PF10852	DUF2651		Protein of unknown function (DUF2651)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	28.40	28.10	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.94	0.72	-3.62	4	152	2009-01-15 18:05:59	2008-07-28 16:51:26	3	2	106	0	11	94	1	77.30	58	96.00	CHANGED	MsEL.hsFhIhPLhIhIlSIsGThhhKshYlMPhlohslhLllshTlas.uFhhWsshYollSFhlSYITllhl..hc.spN	......MsELIFllhIhPLhIhIlSVlGTpKsKTaYVMPIVTFu..sF..LIlsVhsF..sPpFFFWVGMYSIhSFIVSYhTLLF...V+GYclsE...........	0	2	7	7
+10685	PF10853	DUF2650		Protein of unknown function (DUF2650)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Caenorhabditis elegans.	22.90	22.90	23.80	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.24	0.72	-4.50	7	51	2009-01-15 18:05:59	2008-07-28 16:52:14	3	1	9	0	51	41	0	37.20	38	31.25	CHANGED	CPppolaaaacCCGphspECChpLpsWVhlhLhlhhls	..CPpsohaaaacCC....Gpts....p....-CCaplpsWlhlhLhlhhh.............	0	19	24	51
+10686	PF10854	DUF2649		Protein of unknown function (DUF2649)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as Plectrovirus orf 10 transmembrane proteins however currently no function is known.	25.00	25.00	27.70	27.50	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.57	0.72	-3.86	4	27	2009-09-10 17:06:49	2008-07-28 16:52:44	3	1	6	0	0	26	0	66.10	69	99.22	CHANGED	MQNDWIKLKEFFIaIFLFIDKTNVESIpMWNLTQNEYLTLMVGVWlVILFLTWFFLWMVFKIVGYFK	............MQNDW.KLKEFFIHIFLFIDKTNVESIThWNLTQNEYLTLMVGlWIVILFLTWFhLWMlFKIVuYFK................	0	0	0	0
+10687	PF10855	DUF2648		Protein of unknown function (DUF2648)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillales Staphylococcus.	19.80	19.80	21.20	20.60	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.59	0.72	-4.52	3	72	2009-01-15 18:05:59	2008-07-28 16:52:57	3	2	72	0	4	21	0	32.80	78	72.31	CHANGED	MKKLAVILsLuGAAFYGFKKYQN+VNQAPNIEY	MKKLAVI....LsLsGuhaYuFKKYQ.p+VNQAPNIEY..	0	0	0	4
+10688	PF10856	DUF2678		Protein of unknown function (DUF2678)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.10	25.10	28.00	28.00	24.30	23.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.72	0.71	-4.36	4	64	2009-01-15 18:05:59	2008-07-28 16:56:09	3	3	51	0	39	49	0	105.60	58	82.36	CHANGED	M--apTRo.GT....ppPLFGETpsRDRIlNLslGGhTSlLVL.ThlSuhVFPp.PP.slNIFFslCIhhhs.osllL..............................IFWYRQGDL-PKFRsLIYY.hholVLLClCANLYFHDVt+	...................M--asoRTYGTu.GhDN...RPLFGETSA+DR.IINLlVGuLToLLlLV.TlISAFVFPplP.P+PLNIFFAVCI.LssloshlL..............................IaWYRQGD..L-PKFRpLIYYhlhSIlhLClCANLYFH-Vt.......................................	0	13	16	24
+10689	PF10857	DUF2701		Protein of unknown function (DUF2701)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	25.00	25.00	25.30	96.90	24.90	19.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.85	0.72	-4.20	7	13	2009-01-15 18:05:59	2008-07-28 16:57:47	3	1	13	0	0	12	0	63.50	42	74.66	CHANGED	lslhllslshlsalLlYLl+WohlhshhsplKl+llph..TTRRSFppLDsVYYTsDspV.GlNlE	.lslhlllIsIlsaLLlYLl+Woalh-hhNclKl+llph..TTRRSFscLDsVYYTDDspV.GVNVE	0	0	0	0
+10690	PF10858	DUF2659		Protein of unknown function (DUF2659)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	34.80	34.80	34.90	326.80	34.70	34.70	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.52	0.70	-4.94	3	43	2009-01-15 18:05:59	2008-07-28 16:58:51	3	1	43	0	7	30	1	220.10	83	99.91	CHANGED	MTDILDEVLsDcNEEKRLIFFKKLLPIVIIISLIAITIMVINNNNKs+QIcNNQKNGDIFVKoVsLEospsNcELAlsTLEN.LVosSNTKIQEIAtLEQVAIKISsppaSEAKDLLNKIIENKEYSEIoTSYARIuWCSLVI.....DDcNLDIsDKEKLlKYLNYFDDEsKPFWATAoIhKAIWDIKNNMcscAEKNL+uLltSNNoSDLLKDQAKALLsNL-+	MTDILDEVLSDQNEEKRLIFFKKLLPIIIIISIIAITIMVVINNNKDKRIKNNQKNGDILVKTVGLETTKDNcELAFNTLEN.LVTTSNTKIKEIAALEQVAIKIScKKYSEAKDLLNKIIENKEYSEISTSYARISWCuLVl.....DDpNLDIQDKEKLTKYLNYFDDEKKPFWATATIIKAMWDIKNNMKsQAEKNLKNLLISNNVSDLIKDQAKALLVNLNK.	0	1	2	2
+10691	PF10859	DUF2660		Protein of unknown function (DUF2660)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteins with unknown function.	25.00	25.00	41.40	131.50	20.10	18.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.95	0.72	-3.76	4	44	2009-01-15 18:05:59	2008-07-28 17:00:12	3	1	44	0	7	28	0	86.70	82	63.36	CHANGED	LhY.KIss+KKNhhsuptNNI--o.slALNsppp-NK...KLTLQE+IELSWpFLYDITEsILNKFSKEDlhpVNKCGplLaENGVRYEH	LMYKKIAARKKNILPApGGNIDDSPNVALNSQKPENK...KLTLQERIELSWpFLYsITEVILNKFSKEDVIQVNKCGQVLFENGVRYEH	0	1	2	2
+10692	PF10860	DUF2661		Protein of unknown function (DUF2661)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins have no known function.	20.80	20.80	20.90	25.50	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.77	0.71	-3.90	7	19	2009-01-15 18:05:59	2008-07-28 17:02:46	3	1	18	0	0	18	1	103.30	41	36.17	CHANGED	hsLVaVWYH.cspFlaNospaPFWHNlhYpuppYpsallYal-Npss..lPt....stslphlsFKchhscc.phppLpshhs...KIDYMKLpllhs..............schl..spphlLLMDMDCsl	.hsLVaVWYH.cspFVhNTspaPFWHNlpYauppacshVlYhl-sps..sh..pl..Ps...stslphlNFKcshsph.phsplpslhp...KIDYMKlshlhs..............schl..spsalLLMDMDCsl.	0	0	0	0
+10693	PF10861	DUF2784		Protein of Unknown function (DUF2784)	Gunasekaran P, Mistry J	anon	Pfam-B_001600 (release 23.0)	Family	This is a family of uncharacterised protein. The function is not known however it is conserved in Bacteria.	22.60	22.60	22.70	24.30	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.70	0.71	-4.28	45	266	2009-09-11 08:43:52	2008-07-28 17:03:21	3	1	255	0	81	218	171	116.00	35	92.57	CHANGED	YpllADhllllHhhFllFVlhGGlLll..........Rh.thhhlHLsAluWushlphhGh.hCPLTsLEshLRptAGpsuY.suGFl-HYlhsllY......PstlssslphhlGslVlls....ashlhhRp	..........thhADhlllhHhhFllFVlhGGhLsh...........RhhphhhlHlsAlsWGsulth...h.sl..sCPLThlEshLRptAGtssh.ssGFlpHYlhsllY.......Psshs.ssspllhuslVlhs......ahhhh...h.............	0	24	57	71
+10694	PF10862	FcoT	DUF2662;	FcoT-like thioesterase domain	Bateman A, Pollington J, Finn RD	anon	PRODOM	Domain	Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis [1] suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups [1]. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.	20.80	20.80	21.00	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.09	0.71	-4.69	6	71	2012-10-02 20:54:35	2008-07-28 17:09:44	3	2	71	2	9	28	0	151.50	66	81.73	CHANGED	+VLcPYp.csCRYLlcA..........ph+Ap.sulhAhGsFsIsESsYIcsTGHFNAVEl.lCaNQLuYshhApuVtNc.IssLcuWSl-DYhc+QLSshLItphSSpF+KPlNPpKFSGRlps+slphhp+o..h.aLhlssshcFWD-sGGtupGEs.LAh	..............RVLEPYSCKGCRYLIDA..........QYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRV....LRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERT...WRYLKVPCVIEFWDENGGAASGEIELAA.......	0	3	7	9
+10695	PF10863	DUF2702		Protein of unknown function (DUF2702)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	56.30	51.40	21.60	20.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.85	0.71	-4.47	8	43	2009-01-15 18:05:59	2008-07-29 08:49:20	3	1	41	0	27	41	0	140.30	44	69.44	CHANGED	MSRupEIK-KpsLQA+lQhuFSsssuKVLuWLpsStppssussh...tp....s-hs-S+cuFhcLPVlQhGSGLohp...pstspssssIpTIGDFIcSDKclSoLuKcK+spps...pppsslaRlsK-DTKAMlALKpKMRsppRcplRcc	...MSRtKEIpEK.sLQAKLQ.oFSsNsutVLsWLcpsppss.s.sst...pp................p-lp-u+cuFacLPVlphGSGLpFt...pts..tsspc-IpTIGEFI...puD.KKlSoLuKKK++sp.ss.....pRs...shaRlsKDDoKAMlALKpKMRcsp+-slRpp.....	0	3	13	24
+10696	PF10864	DUF2663		Protein of unknown function (DUF2663)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as YpbF however currently no function is known.	22.90	22.90	24.10	24.50	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.69	0.71	-3.93	10	52	2009-01-15 18:05:59	2008-07-29 08:50:26	3	1	51	0	18	47	0	129.20	42	87.62	CHANGED	QMLpALIcRKcKaE+hc+QshhhphAullshshallalhsKshu...hphsthLutlhusssaLhhlLssuhuYssuhYaKKKcEKAEsEaHtLRCEIIQKSpDLWsppEpW+uRcpVFchMK+cYDINLYaE	.....QMLpullcRKpKaEphtcpshhaphsullshslhhlalhhpshs....ts.phhlpthlupssaLhallhsuhuY.hsuhYaKKKcEKAEs-FHpLRCEIIQKSsDLW.ps-pWcsRcplFchMK+cYDINLYaE........	0	4	11	14
+10697	PF10865	DUF2703		Domain of unknown function (DUF2703)	Pollington J, Finn RD	anon	PRODOM	Domain	This family of protein has no known function, but it may be distantly related to the thioredoxin fold. It contains the CXXC motif that is characteristic of thioredoxins.	20.10	20.10	20.80	21.60	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.70	0.71	-4.18	14	60	2012-10-03 14:45:55	2008-07-29 08:51:33	3	10	50	0	45	62	2	107.50	29	63.03	CHANGED	LsIcWp+Lsss.stTC-RCusTucslppAlppl+phLp.hGlpVplpcttlsspphuht...hESNpIhIsG+slEphl.uupVsposC....Chss.sDscCRslphssppYEslPtcLllcAu	.................l.Ipa.hLshs...TCsRCtsTtpslpcAlpplpthLp.hGlclhlpch...plss...p..phsht.......pSspIhlsGpsl-.hh.shpsspohC....shss.ssspCRsh.thp.G....ppY-shPtthIhcAh.........	1	21	40	43
+10698	PF10866	DUF2704		Protein of unknown function (DUF2704)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	19.90	19.90	23.70	22.80	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.17	0.71	-4.87	12	19	2009-01-15 18:05:59	2008-07-29 08:53:22	3	1	19	0	0	16	1	161.50	41	78.97	CHANGED	sss.sss-tpssRKsVcuss-EYTVDGLKLKstYVtYYKpLphlVDFhVMhlSKplsMKEY-pVYSLGRQLYElLRulFVDEPFKLWLEpNspchsss...+cpIhKhLQspLphslt....hKosTFKshlhNlLNocLs...s+YDsustYIKPNCIVsTaNCCsLsFc.	.............tsss.......tpspp+slcs..cpaTVDGL+LKosYVtYYKQLKtLV-hlV..halSK.plshK-YcEVYoLuRQLYEllRulFV...DEPFKLWLEp.....NsppLsss..tth+D..cIaKpLpspLcsssss.......scssThKshllNVlNscLstp.scaDssstYlKPNCIV.TasCCsLsFc..............................	0	0	0	0
+10699	PF10867	DUF2664		Protein of unknown function (DUF2664)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is a viral family, annotated as UL96. Currently no function is known.	21.20	21.20	21.20	29.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.86	0.72	-3.36	8	32	2009-01-15 18:05:59	2008-07-29 08:54:00	3	1	29	0	0	24	0	91.60	35	73.95	CHANGED	MRhsLE+pQ+cFL+pshGscHPLospQslpsh+stsRpps+psppslpsVustlh.cp+tpl+........cppppA+pLQ+.hDlD-hlDoLsElKDs	.....MRhcLE+pQ+pFL+csaGspH.LoppQulpshcsss+pppc.sppssppVustlh.cp+uplp........p-hpps+pLpp.hc.VD-hLDoLsElKDs...................	0	0	0	0
+10700	PF10868	DUF2667		Protein of unknown function (DUF2667)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Arabidopsis thaliana.	20.90	20.90	21.10	21.20	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.60	0.72	-3.61	5	19	2012-10-01 23:31:40	2008-07-29 08:56:03	3	1	4	0	17	30	0	84.20	29	94.17	CHANGED	MGSLRLSTVAIA.VVVCLSILLISPTEVDGRtVCDhstGtCosh...STCs-sCpslc....usFpGGECtshuuhsGholCaCC+s...VpSuAEhESM	..................h.slh.lllClSlL.Ll....SPh.....c...lsG..p..h..C.D.h.......hGsCs.h......tppCscsC+php....ppatGGpChshst.ss....shChCCh...............t.........	0	10	10	11
+10701	PF10869	DUF2666		Protein of unknown function (DUF2666) 	Pollington J, Finn RD	anon	PRODOM	Family	This Archaeal family of proteins has no known function.	22.00	22.00	22.60	33.90	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.74	0.71	-4.12	9	43	2009-01-15 18:05:59	2008-07-29 08:56:51	3	2	30	2	32	46	0	127.30	38	94.58	CHANGED	E-+IpFTAK+GKWhVlK+LhIDEpTspl-IARLLASIsETlstKI.-Fhs..hDhc+Ic-hhsthhchKK....EE-Iscslpth+S.tsophhst...ppEs+.hl+ch........Lp+LGlphcVsuK.lEKYlEKs	...................E-+IpFsA.....K+GcWhVsK+LhID-pTpsh-IARlLASIsETlstKIP-YLs..hDlctlpphhc-lhphKK....-c-Ispslp+LKSPuTo+Klsphhppc-tK.hLKchL.p...hlLpRlGlppclssK.lEKYlEK.......................	0	3	4	19
+10702	PF10870	DUF2729		Protein of unknown function (DUF2729)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	20.20	20.20	79.20	79.00	19.80	18.40	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-9.07	0.72	-4.24	8	13	2009-01-15 18:05:59	2008-07-29 08:59:52	3	1	13	0	0	13	0	54.80	65	84.38	CHANGED	NLLsYCKLKLVKpVSKTVuuLLCKCV....APEDo.D..sGDRYlQINNNCNFIYINVVp	.pLLTYCKlKLVKuhSKphuuLhC+CV...hus-Ds.D...GDRYhQhNNNCNFIYINVVK.	1	0	0	0
+10703	PF10871	DUF2748		Protein of unknown function (DUF2748)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	25.00	25.00	791.70	791.50	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.60	0.70	-6.07	2	44	2009-01-15 18:05:59	2008-07-29 09:06:05	3	1	44	0	7	27	3	439.80	89	99.98	CHANGED	MoslYHILc+lPAI.+pDM.lEYEpLA.pLlpSGKLRlDs-sphNFsRhoEPuLNlslhlSpEELssP+L..cTpthh.NlY+p.hpc....pKlppIhssLpKphth..sVcp-lh.hLARlFVQSAHPIVI+WLLLp+sEVFloYSppIGDhMDhsoWphsGtNSGMQShNGpslAIaVSCGGNP..Fspp.p-pshYGsGasAhARLQIIAAQELGHaADIhRD.pup.lsRHSsN.ShTKApspVhhAR+sDl.+CaplLppL.psGhpp.lsYEpplKFYptNKVpGlKlhhh+hh.FhYK.+Lh.h.pppshIFV+haKs-pY.uLMlcAMhhDM.uNLpPtA-VYKpcsP-hEEAIAClEALARVPQQsIKWGalTThphMpDLYhIYYppVIPSLIspYphITGcsY.Rsh.....NahSph.hap.KKL..hhK....PsREl	MTSIYHILDRVPAIYKQDMEIEYEHLAMQLIKSGKLRIDTDDCCNFARFTEPALNISLMVSpEELTSPHLIPETTKLFQNLYRNSASD....QKIKSIFDNLKKQIQKLQPVKKEVTEMLARIFVQSAHPIVIRWLLLNKTEVFLTYSHNIGDMMDMVSWQRVGGNSGMQSTNGKDVAIFVSCGGNP..FAENNKDHPTYGNGFAAsARLQIIAAQELGHFADIKRDDKGRQITRHSANFSGTKATDKVRIARKNDIIHCHNLLuKLLKAGMKKQLDYETKLKFYNANKVSGLKVYAIKFMIFIYKFRLLNYSSRNNLIFVRKFKTDcYMALMI-AMFKDMQANLSPsADVYKNKNPEIEEAIACIEALARVPQQTlKWGYLTTKETMHDLYKIYYNEVIPSLITSYNAlTGENYpRDFKKPKSNFFSKINIFSNKKL..VLK....PVREL.	0	1	2	2
+10704	PF10872	DUF2740		Protein of unknown function (DUF2740)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function has a highly conserved sequence.	25.00	25.00	30.20	122.00	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.46	0.72	-4.30	3	83	2009-01-15 18:05:59	2008-07-29 09:12:15	3	1	81	0	1	6	0	48.00	94	100.00	CHANGED	MPKQLSPDQDKLHKNILRDRFLSSFKQPGRFRAELEKVKLMQKEKGHE	MPKQLSPDQDKLHKNILRDRFLSSFKQPGRFRAELEKVKLILKRKGHE	0	0	0	0
+10705	PF10873	DUF2668		Protein of unknown function (DUF2668)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as Cysteine and tyrosine-rich protein 1, however currently no function is known.	26.20	26.20	26.40	26.40	25.50	26.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.20	0.71	-4.06	5	49	2009-09-16 09:25:17	2008-07-29 09:12:45	3	2	35	0	26	38	0	129.00	62	85.86	CHANGED	MDALR..LPRRPGVLL.KllLLFVYAGDCpAQCGK-C+SYCCDGSTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRAAHINAIS..YPM.APPPYTYDHEMEYsTDL.PPPYSPAPQASAQRSPPPPYPGNSRK	....................R.....tshlhL.cllLLhlhA-cCLA.QCGpDC..+SYCCD..GoTPYCCSYY.AYIGNlLS..GTAIAGI...VFGIVFIMGVIAGIAICICMCMKNp.Ru.TRVGllRTo+INslo......oYPh...sPP.PYsY-aEMpassDL.PPP..YoPsP...ptssphSPPPPYPG.s+K.......................	0	4	7	13
+10706	PF10874	DUF2746		Protein of unknown function (DUF2746)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	21.90	21.90	22.20	22.20	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.90	0.72	-3.78	5	73	2009-01-15 18:05:59	2008-07-29 09:14:46	3	1	72	0	1	59	0	60.10	54	51.59	CHANGED	I+pQVsNoHDTNlRDDLD-lt..........EhVp-GF+clc+DIstL+E-LsTERpERIEGDRRR-	..I+-QlsNTH..-TNMRDDLD-lt......................................-hV...+-GF+plp.......R.DIuGLREEL..RTERlERIEGD+R+........................	0	0	1	1
+10707	PF10875	DUF2670		Protein of unknown function (DUF2670)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	29.50	39.60	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.65	0.71	-4.14	3	44	2009-01-15 18:05:59	2008-07-29 09:15:40	3	1	44	0	7	29	0	139.20	78	86.46	CHANGED	MWQALRRLIAANPMGFFLWSIITKWYLIIAVASLITLYYTVLGLKKIGFIDYFGRTTVEILDTSKAVAQNCTsKLGPNWs+LVN.......FWNCLSDPGEYcHEEGTGAKVLEDEINKLhsKQAD......SluDscsPIINPYEcLsNsN	.......MWQALRRLhAANPMGFFLWSIITKWYLIIAVASLITLYYTVLGLKKIGFIDYFTETTVEILDTTKAVAQNCTTKLGPNWN+LVS.......FWNCLSDPGEYKHEEGTGA+VLEDEINKLTPKQAD......SlADAE+PIINPYEtLENsN..................	0	1	2	2
+10708	PF10876	DUF2669		Protein of unknown function (DUF2669)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	34.40	34.30	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.57	0.71	-4.45	4	30	2009-01-15 18:05:59	2008-07-29 09:16:31	3	1	24	0	4	23	0	126.40	50	93.33	CHANGED	hpIEslTYsMTPANAhsAWsuLKpAhtLLpusDlsslGcpps..huushLsslLuNLGDPulptlEslVLKaTosc.tDGppYRLS..-RFspHFNpaRuHLl.VLhEGLhYQaADFFhGGsuhhssh.s.hstsp	.....hpI-slTYhMTPANAMsAWpuLKpAhsLLpuhDhsuluNsps.....huussLuslLupLGDPulpElEslVhcpTuhcssDGsp.YRLS..DRhspHFNs+RsHLl.VLhEGlhYQauDFFsGGhuuhpsl.P..sApp.......	1	0	2	3
+10709	PF10877	DUF2671		Protein of unknown function (DUF2671)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Rickettsia spp.	25.00	25.00	31.50	186.70	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.16	0.72	-4.19	2	42	2009-01-15 18:05:59	2008-07-29 09:17:29	3	1	42	0	6	19	0	90.00	93	99.82	CHANGED	MQEKELSNNFLEEQpp.KEDsSPF.DlKYICQASLLITDSIRKGYDVTQLsNGDINVTElRIVNVHYNWNSEKGKFVKTNQIEFNNsKGG	MQEKELSNNFLEEQE...KSKEDsSPFFDVKYICQASLLITDSIRKGYDVTQLPNGDINVTEVRIVNVHYNWNSEKGKFVKTNQIEFNNSKGG.	0	1	1	1
+10710	PF10878	DUF2672		Protein of unknown function (DUF2672)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Rickettsiae.	20.70	20.70	23.40	38.90	19.20	17.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.25	0.72	-4.24	3	43	2009-01-15 18:05:59	2008-07-29 09:18:14	3	2	43	0	7	19	0	67.80	79	64.98	CHANGED	hIIKclKKIKAYF..IKS.hIKNIDcSLETEQlNFYLKKIINLEGYYaGNYDLTTIKEKYYTLI...INNDL	..........IIIKELKKIKAYLINIKSSIlKNIDEPLETEQlNFYLKKIINLEGYYHGsYDLTTIKEKYYTLI...INNDL.......	1	1	2	2
+10711	PF10879	DUF2674		Protein of unknown function (DUF2674)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be conserved to Rickettsia spp.	25.00	25.00	150.20	150.10	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.16	0.72	-4.24	3	40	2009-01-15 18:05:59	2008-07-29 09:18:51	3	1	40	0	6	13	0	67.00	93	99.93	CHANGED	MQNPTQKVISFSEHKADIERIKKuIEEGWAIVKLVPNKDRFIGLLEKISHAE.DETIYIPPRKKIIVN	MQNPAQKVISFSEHKSDIERIKKSIEEGWAIVKLVPNpDRFIGLLEKISHAE.DETIYIPPRKKIIVN.	0	1	1	1
+10712	PF10880	DUF2673		Protein of unknown function (DUF2673)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Rickettsiae spp.	19.80	19.80	19.80	89.00	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.02	0.72	-3.93	3	42	2009-09-11 07:30:40	2008-07-29 09:21:59	3	2	42	0	6	19	3	64.20	87	78.54	CHANGED	MKNLLKILLILAFSAPVFASS...QlP.DPASVTTTQIpAMSTsDQQAWVASLTADQYNMLSPDVQKW	MKNLLKILLILAFASsVFASS..MQMP.sPASVTTTQIQAMSTDDQQAWVASLTAsQYNMLSPDVQKW....	1	1	1	1
+10713	PF10881	DUF2726		Protein of unknown function (DUF2726)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	24.70	24.70	24.80	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.28	0.71	-4.52	35	880	2012-10-11 20:44:46	2008-07-29 09:23:18	3	9	678	0	167	661	25	119.50	22	36.87	CHANGED	pc......tLhsssEpshhptLcpulss....ph.plhs+Vphu-llps......stpptppAhsphsu+phDFllsD.psh...pslssIELsss..sHp......psptppRDthhcpshcsAGlPllclphppshssspl+cpl.tsl	.................................................t...lhs.tpEtthhptL.phlsp.........ph.hlhs..pVphspllp...........ttpphhph.hp.h.hs.p.tp......hDaVlhc.t..psh.................pslssIELDss..p.Hh.............ptp..ptcRDthhpplhcpAGlPll.Rhp.pt.....p............hh......................................	0	45	92	132
+10714	PF10882	bPH_5	DUF2679;	Bacterial PH domain	Pollington J, Finn RD, Bateman A	anon	PRODOM	Domain	This family of proteins with unknown function appear to be related to bacterial PH domains. This family was formerly known as DUF2679.	22.30	22.30	22.30	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.93	0.72	-4.22	27	319	2012-10-04 00:02:25	2008-07-29 09:24:37	3	5	295	0	86	264	11	101.30	19	37.49	CHANGED	lcYtl-cpsLhI.pthhu..phpIPh.....spIpplphssshh..tsl+lhGhuthtahhGphh.hpchGpsphasTp.scphlhlcTss.psYsISPcsh-pFhppLcp+t	...........................................htlpsppl.l.ps.hs..phpIs.h.......spIp.s...l.........p.....h..h.s...sls.....tth..Rs...Gsu..ssthhhG.pFp..hp.shu.p....hhhh.sTp..spsllhl.c.Tc...c..psh...h..l....oscp.pt.........t.......................	0	36	71	81
+10715	PF10883	DUF2681		Protein of unknown function (DUF2681)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 81 and 117 amino acids in length.	27.20	27.20	27.20	28.30	26.30	27.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.91	0.72	-3.78	13	42	2009-12-08 16:02:13	2008-07-29 09:25:47	3	1	32	0	7	42	0	83.90	34	81.75	CHANGED	M.hslhlh.ussulhuslhualha+sc+upcc........tpLppEppQlpsEtpstpspVKNhcl+QKNEEss+phSpcsV.-pLppcG.hR.D	...........hshp.l.lhuhsulhshlhuYlha+lcptccc.......stpLhppNpQLpsEpsstpspVKpapl+pKN-EsspphuRssll-pLpppG.hR-.......	0	1	5	7
+10716	PF10884	DUF2683		Protein of unknown function (DUF2683)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Methanosarcinaceae.	22.80	22.80	25.00	24.70	21.80	21.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.69	0.72	-4.05	7	17	2009-01-15 18:05:59	2008-07-29 09:28:00	3	1	13	0	12	17	10	74.50	35	88.79	CHANGED	MVQAhlsIoDcoNpILsIlKAKYsLKDKStAI-hllppYpp.hLEP.EL+PEFlEchppIhc.cchl.lsol-sL+thhtt	...................MVps.lslsDcsNpIlpIhKApasl.cKS.AIshhlppapp.hhEs.El+PEFlcchpcl.KtpchIclsshcsLRccht.h...	0	2	4	6
+10717	PF10885	DUF2684		Protein of unknown function (DUF2684)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as yqgD however currently no function is known.	25.00	25.00	35.70	35.70	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.12	0.72	-4.12	2	241	2009-01-15 18:05:59	2008-07-29 09:29:20	3	1	239	0	7	33	0	76.70	77	95.94	CHANGED	hstDsThoLpVtsTGSLSVNpYGWINIWhAILGpFFsQFPhFFEuph.lhps.h..hsDNAsIhRIYhL.F.sllGhK......p++ss	........MstDsThoLpVpsTGSLSVNpYGWINIWMAILGQFFTpFPLFFESCLILLKTWLEIFPDNAGILRIYLLQFSAIVGYKT..........RRAA.......	0	1	1	2
+10718	PF10886	DUF2685		Protein of unknown function (DUF2685)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as uvdY.-2 which is an open reading frame within uvsY. However currently there is no known function.	25.00	25.00	31.50	31.30	23.00	21.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.65	0.72	-3.95	6	36	2009-01-15 18:05:59	2008-07-29 09:30:35	3	1	35	0	0	25	0	53.80	53	96.13	CHANGED	splCVVCKpPlccA.LuVcTspGsVHsG.CtpalpEhslSESs.....-p.LpETQLLh	...cICVVCKpPI-sA.LVV-T-pG.PVHPGsChsYlp-h..P....lS..ES.s.....-cpLsETQLLl	0	0	0	0
+10719	PF10887	DUF2686		Protein of unknown function (DUF2686)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as yjfZ however currently no function is known.	25.00	25.00	69.60	69.50	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.75	0.70	-5.67	3	406	2009-01-15 18:05:59	2008-07-29 09:32:52	3	1	257	0	2	128	0	263.10	67	99.79	CHANGED	MSMPLSNAhsoQasTsNHFLHHPpVDSElT+Ka.cYARhDLENIYL.PLsRGNNHNYDGKSsVEIRKLDISKpSW.PFNYVTssCREaDGITTTGRMLYRNLKITSALDEIYGGICKKAHAATELAEGLRLNLFMKSPFDPVEDYTVHEITLGPGCNVPGYAGTTIGYISTLPASQAKRWTNEQPRIDIYIDQIhTVTGVANSSGFALAALLNANIELGNDPIIGIEAYPGTAEIHSKMGYcVIPGDEDAPLKRMTLQPSSLPELFELKNGEWNYIGK	.......MohP.....po.h.hssah.HaspsDp.lphKa.phARhDpENIYL.PLsRGNNHNYDGKSVVEIRKLDISKps.W.PFNYlTpsC+E.DGITTTGRMLYRNL+ITosLDEIYGGICKKAHAuTELAcGLRLsLFMKuPF-PVEcYTVHEITLGPGCNVPuYAGTTIGYISTLPASQAKRWTN.EQPRIDIYIDQIhTVoGVANSSGFALAALLNANI-LGNDPIIGIEAYPGoAtIauthGYcVIPGDEDAslKRMTLpPSSLPELFELKNGEWNYltp........	0	2	2	2
+10720	PF10888	DUF2742		Protein of unknown function (DUF2742)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of phage proteins are the product of the gene phiRv1, however no function is known.	22.70	22.70	22.80	22.70	21.80	22.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.36	0.72	-4.06	4	68	2009-01-15 18:05:59	2008-07-29 09:33:11	3	2	51	0	7	28	0	93.70	67	74.31	CHANGED	ASRtVSWWsVHpaVtPhLstA..GsWPMAGTPAWstLDDsDPhKWAAlsDAucHWsLRVETsQpA.A-ASp-VSAAADWsuluRclpc+cshahtRshl	..............sSRtVSWWSVHEaVAPsLsAA...spWPMAGTPAWssLDDsDPhKW.AAICDAARHWALR..VETCQ.....sApA-ASRDVSAAA.DWPAluREI.pRRRssYItRssV.................	2	3	5	7
+10722	PF10890	DUF2741		Protein of unknown function (DUF2741)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as ubiquinol-cytochrome C reductase however this cannot be confirmed.	24.30	24.30	25.00	24.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.51	0.72	-3.84	4	42	2012-10-01 20:10:32	2008-07-29 09:36:22	3	2	24	0	29	45	0	69.90	60	74.83	CHANGED	MGKpPl+LKAVsYALSPapQKVMPGLWKDlsuKItHKVSENWluAsllhu.PlsGThpYA.aYpEpEKLcHRY	.........MGKt.PVRhKAVVYuLSPFQQKlMsGLWKDlPsKIHHKVoENWISAsLLls.PlVGTYpYst..apEpEKLpHRa........................	0	8	21	25
+10723	PF10891	DUF2719		Protein of unknown function (DUF2719)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Nucleopolyhedrovirus.	21.40	21.40	21.90	21.50	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.98	0.72	-4.30	5	33	2009-01-15 18:05:59	2008-07-29 09:37:14	3	1	32	0	0	27	0	74.40	32	83.87	CHANGED	MLRALKRRFKsAssEp+REED..VVLCPRCYFVAPGcISVADYTRMHIKFNEQFAD+CsNNFsVTQPKTWuNYoNCSALYYPL	..........................................cc..psp..VVhCs+ChFVAPhSlSaEEYlcLHcpFNphhsspC.........................h..t..................	0	0	0	0
+10724	PF10892	DUF2688		Protein of unknown function (DUF2688)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as KleB however currently no function is known.	25.00	25.00	25.00	59.10	24.70	17.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.00	0.72	-4.31	3	19	2009-01-15 18:05:59	2008-07-29 09:37:23	3	1	15	0	2	9	1	60.30	64	84.44	CHANGED	MsKGKIE..IVETsCRRCGKSIRTLSHSLIGAD-LREKLGGICG-CITPEEDpcITEuhLuA	..MsKGKIE..IlcTsCRRCGKSIRTLS+SlIGAD-hREKhGuICGsCITPEEDpclpEhhLtA.....	0	0	1	2
+10725	PF10893	DUF2724		Protein of unknown function (DUF2724)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteins with unknown function.	25.00	25.00	26.00	25.70	24.50	24.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.67	0.72	-4.11	4	172	2009-01-15 18:05:59	2008-07-29 09:38:01	3	1	164	0	8	86	0	64.50	68	94.77	CHANGED	MLpsEPSFASLLVKQSPuMHYGHGWIhscDGKRWHPC...+SQsELLtGLuTK+.tpp.........allKul+plpR	...MLTKEPSFASLLVKQSPA...M...H...a...GHGWIMGcDGKRWHPC...RSQDpLLAELSTKKpGp..........WLLKuhhRLF+.....................	0	0	2	6
+10726	PF10894	DUF2689		Protein of unknown function (DUF2689)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as TrbD however currently no function is known.	25.00	25.00	30.10	29.70	20.10	18.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.10	0.72	-4.19	4	128	2009-01-15 18:05:59	2008-07-29 09:38:19	3	2	101	0	2	84	0	58.30	79	62.49	CHANGED	MNMRNINlITAhSVPsKoVSDDFMHAVLSNCTTRIVLPAPKcFuSESLPHNFNMAAVGVMK	..MNMRNINVITAhSVPsKoVSDDFMHAVLSNCTTRIVLPAP+cFuSESLPaNFNMAAVGVMK.........	0	0	0	1
+10727	PF10895	DUF2715		Protein of unknown function (DUF2715)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Treponema pallidum.	21.70	21.70	22.10	23.10	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.21	0.71	-4.77	8	104	2009-01-15 18:05:59	2008-07-29 09:38:40	3	1	15	0	11	46	0	146.80	34	86.65	CHANGED	Chh......sshAupVFlSP+lGhsuhhhhGpsh.upthptst..p...........asPhlG.lsVulhAcNGhshssslDAuLTpLMFRuQsLlGYuhRhG..........................................shtalPsoGlsl....huop-ct........lhG......VPlpLshQaaFssahGl-sssouuVGlshp.sh.................................Dhpa......................................spa.........plPlolRlGPVFRl	..........................................................................shsspl.lSs+lG.ht.h.hG.ph.s.hh...........................sPhhG.lsluh.Ac.NGhhhthslDAuLTpLhFp.......upsLhGYuhR.G..........................................t..hhhs..hhsh....hspttt..............u......lslplthpahhsthhGlshshssuhsl.......................................s.th.............................tpa..........hhPhslplGPsFRh...................................................................................	0	11	11	11
+10728	PF10896	DUF2714		Protein of unknown function (DUF2714)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycoplasmataceae.	23.90	23.90	26.40	51.60	22.60	23.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.67	0.71	-4.39	7	55	2009-01-15 18:05:59	2008-07-29 09:39:24	3	1	52	0	16	37	0	145.60	37	85.27	CHANGED	spYcclhps.s....FlsYppLhspsLLcss.shpSs.hpcahcphh.Aatp+h-lVFcsFVIoashN.+FShstLlPhlstsEsSNo-uhN.hpssNsppapphLsp.aNphhp.pLhppp+hVElhPslIlFhuppTcpLKllFscphlhs	...pYc-hhssss....hloY-pLhuoVLLcsplGFpSclYpcFhp+hphAhcp+h-IhFcsFlIoFNlNLKFSsshLlP.lLsspEsSso-AlN.Fpss..ps.paspFLts.aNphIp.pLlpps+hVEIhP.slIlF+Spp.ssoLKllFScchl.o......	0	9	15	16
+10729	PF10897	DUF2713		Protein of unknown function (DUF2713)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	65.30	65.30	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.59	0.70	-5.12	3	258	2009-09-11 09:11:29	2008-07-29 09:40:13	3	1	235	0	1	98	0	209.60	84	88.19	CHANGED	VFLIEQINDLKMWVNKYIDDCTDEDLNDRDFIASVVDRAIFHFAINSICNPGDNKDATPIERCTFDVETKNGLPSTVQLFYEESKDNEPLANIHFQAIGSGFLTFVNACQEHDDNSLKLFASLLISLSYSSAYoDLAG..+VNINEYNENYLKAQFEELSQRDMKKYLGEMKRLADGGEMNFDGYLDKMSHLVNEGTL-PDILSKMRDAAPKLIDFAKSFDPNSKEKIKILTDTSKLIYDLFGVKSEK	..............................MWVNcYIsDCTDE-LNDR-FIASVVDRAIFHFAINSICNPtDNKDAo.IEpCTFDVETKNsLPSTVQLFYEESKDNEPLANIHhQAIGSGFLTFVNACQEHDDNSLKLFASLLISLSYSSAYsDLut..pV.INE.NEsYLpAQFEcLSQRDMKKYLGEMKRLADGGEMNFDGYLDKMSHLVNEGpL-PDILSKMRDAAPpLIsFAKSFDPsSKEcIKILTDTSKLIYDLFGVKSEK.............................	0	1	1	1
+10730	PF10898	DUF2716		Protein of unknown function (DUF2716)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.00	21.00	28.90	24.40	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.17	8	75	2009-01-15 18:05:59	2008-07-29 09:40:36	3	1	68	0	20	62	0	133.90	45	81.17	CHANGED	NWhtLScpEh-plW-+lYcca+F+..PuhStaPSh+sPsPalTaDlSshFsstuthss.....--lEpcsL+AFppsTtssEahhALDWQH-CYhlsP+lshp+D...EFs.EWhlPVaPNGDYYFFlpcDF+WGhLGHPWEpSITIFGc-LI	..............tWh.ho-pE.-plWsclasch.cFp..Pu..h..s..taP.uFchPs.PalT.a..clSph...h..sc.ss.hss........h--L-ccsLpsFpc.....sTss..sEahhALDWQH-CYhhsPHhph..p+s............EFs.EW.......l...PlF.PNGDYYFFlpcDFcWGhLGHPWEpoIolFGctLI...........	0	6	14	16
+10731	PF10899	DUF2743		Protein of unknown function (DUF2743)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	21.10	21.10	21.60	22.30	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.28	0.71	-4.92	9	148	2009-01-15 18:05:59	2008-07-29 09:41:27	3	2	147	0	18	78	0	120.60	50	33.97	CHANGED	pphh..pYssEchpa.h.s+pp.......lp.hshPMsCFsDIPLpclp.Hsp.....tYGpauIuhcKchulppshsPVhY....h.pss.hhpslhphhptl.s.........................................ptpspptl.psLthhhhhlKsa-ss..............pcsFYsE+EWRhlssh....t.....hh.cpp.....otpph..pt.hphp....+FsssDIcaIhls	............sSWSYRNGQRTVYGD..................................................SPVVCFTDMPIAAYLE.T.GVRRL..ERNEKIGLYAIVLPKEQM.FN..YGARPVIY.......GLDpHN.hp...............................................................................................................................................................................................suphppucph.c.hs...............................................................................	0	8	11	15
+10733	PF10901	DUF2690		Protein of unknown function (DUF2690)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.70	21.70	21.70	23.80	21.10	21.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.63	0.72	-4.03	6	208	2009-01-15 18:05:59	2008-07-29 09:43:39	3	5	124	0	29	142	0	109.60	43	54.09	CHANGED	pG+ShsGKsP.h.uCstsh.....s+hlsusshshuhVEL+aSsoCKTAWA+lT...s.s.s.cs.A.lhRsoDGKclss.uAGGsGch.....ssGpTssYTPMVhshDsRpuhAp	...............................tYDGKsPh.h..s.......oCDssuhs.....tcsphlsp......ss..........t...h......u.h.VELRaSssC+sAWAKlsl.....s.ssshss.A.....Ahl.......s+...ts..sGp.thos.sSsuGNGsl.........ppGQTS..sY..TsMVaDLss......................................................	0	9	22	27
+10734	PF10902	DUF2693		Protein of unknown function (DUF2693)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	21.40	21.40	21.40	21.70	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.70	0.72	-4.07	6	77	2009-01-15 18:05:59	2008-07-29 09:44:26	3	1	68	0	3	63	41	71.70	32	60.54	CHANGED	GpHpllFcKuDGolRsMhATRDshLl.spppGc.hh..sscsp..RKEscES....lsVYDlcscuWRSFplD+LISlsGhsltcLltl	............................phhapKsDGolRptpGThcsshhs..hppttp.........ts....p+cspss....lsaa.Dl-tpsWRoF+h-pLlsl...........h......	0	0	3	3
+10735	PF10903	DUF2691		Protein of unknown function (DUF2691)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.50	26.50	24.40	21.50	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.99	0.71	-4.39	9	107	2009-01-15 18:05:59	2008-07-29 09:49:18	3	1	92	0	9	81	0	144.00	44	95.65	CHANGED	pRGloF-IPNtYsphLhcILpsl-IssasW..l.ustEuYhltcGpL.scpLFscs.plhpGtsh+chlcss.YYlIFsDLKAaPpGchls-IpTYE-FhcScCElllLlsDusYVslYsKDpchlEhLYpNAhppuFppl-YITDENDsRTpLoV	...KRGIoh-I..Ps..p..Y..ssh.Lh..+lLKP.lcIs..s...a....sWh.l.sspEuYllhp.spL..sptLFsc-spl.h-Gp-L+cllK..sNhYYlI..FsDLKAaPKG....c..hl.....h-IpT.....YE..EFhcScCElVlLlsDupYlpIYsKspchIEhhYpNAhspGFh.V-YlTDENDsRTpLoV...........	0	2	6	7
+10736	PF10904	DUF2694		Protein of unknown function (DUF2694)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacterium spp.	20.90	20.90	20.90	21.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.25	0.72	-4.01	3	64	2009-01-15 18:05:59	2008-07-29 09:49:44	3	1	61	0	7	23	0	99.50	77	97.97	CHANGED	MTDANPAFDTVHPSGHILVRSCRGGYMHSVALSEuAMETDAETLAEGILLTADVSCLKALLEVR-EIVAAGHTPSAEVPTsRDLDVAIEKLLAHQLRRRs+	..............MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETLAEAILLTADVSCLKALLEVRNEIVAAGHTPS....AQVPTTDDLNVAIEKLLAHQLRRRNR.............	0	1	3	6
+10737	PF10905	DUF2695		Protein of unknown function (DUF2695)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	30.50	29.90	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.69	0.72	-4.24	6	82	2009-01-15 18:05:59	2008-07-29 09:50:16	3	1	77	0	8	46	3	53.30	52	46.29	CHANGED	Llsa.lsc+Lss.sCDHTh+auppahpp+plsh...csllchLtcpGGaCDCEllhN	........LhDY.VDE+Lu.cp.sCDHThRaupcahps++l-h...EolhEtLpEhGGYCDCEIlhN..	0	5	8	8
+10738	PF10906	DUF2697		Protein of unknown function (DUF2697)	Pollington J, Finn RD	anon	PRODOM	Family	This is a eukaryotic family of proteins with unknown function.	22.80	22.80	23.40	22.80	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.30	0.72	-3.97	9	39	2009-01-15 18:05:59	2008-07-29 09:50:42	3	1	38	0	29	37	0	66.00	40	78.69	CHANGED	EEWLYhKLlsSsuFppaVR+lasKlNtIp.pPh.cppss.sphh....Y+PTphpKFpAFRllaaDEhKpoF	.....EEWLYh+LlsSPuFHRFVR+lapKVNtI+.s..scps.ss..phl......a+PTt.hpKhpAaRhLFhDEh+ssh...........................	0	3	14	25
+10739	PF10907	DUF2749		Protein of unknown function (DUF2749)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins appear to come from the Trb operon however currently no function is known.	22.00	22.00	22.30	22.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.31	0.72	-4.10	8	39	2009-01-15 18:05:59	2008-07-29 09:50:55	3	1	18	0	15	40	1	58.90	40	41.19	CHANGED	MSptVlIALlls..VAuuuusATslIVpsc.......susssuhuEEQRssRE+FFGusp-.PPI+cGQEM+PRW	.....................................................................s...tt.ps+REpFFuus.c..-IRGGQcMcPRW.......	0	2	6	11
+10740	PF10908	DUF2778		Protein of unknown function (DUF2778)	Gunasekaran P, Mistry J	anon	Pfam-B_001575 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	24.10	24.10	24.20	24.90	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.82	0.71	-3.90	28	375	2009-01-15 18:05:59	2008-07-29 09:53:21	3	7	237	0	108	328	3	100.10	35	40.73	CHANGED	tpl-AaSGhGphhDcPctsslc.hGshPPusYhlh.R-u..........................................hhcGVc..AhRLpPl....................G.pGtSpGClohcshscFhphhcthchp.ph..ssVPuh	...........t..h.AaSG..st.hhspPp..hss.t.tGshPstp.Y.lh...Rps..............................................................hh.....pGVp..shRLpPs...................G.hG.SpGClohp.....shs.....pF.phhthh.hp.ph..shlst.......................................	0	19	44	70
+10741	PF10909	DUF2682		Protein of unknown function (DUF2682)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	24.80	24.80	24.90	90.40	21.80	24.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.61	0.72	-3.70	7	13	2009-01-15 18:05:59	2008-07-29 09:54:05	3	1	13	0	0	12	0	82.20	44	87.91	CHANGED	LhsVQcssLcLspEspsaLssssss..............pLEpcLhpLlhpsNsIsFD.....cppthp.LKsNlhsCINIhIDLIhIKphh	LltlQssVLDlh+ElspaLNsssPsh.........cthshL--hLTKhLhcuNAIsFD.....cppsLchl+sNIshCLNhhIsLITIK+Yl.	0	0	0	0
+10742	PF10910	DUF2744		Protein of unknown function (DUF2744)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	25.00	25.00	26.00	25.70	24.50	18.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.42	0.71	-4.30	6	89	2009-01-15 18:05:59	2008-07-29 09:54:53	3	1	88	0	4	50	1	133.50	44	89.78	CHANGED	ch.opEssDPscPEEtFlWsLpslPshsGssu......lhsssaL+thSKHLW-CGht.sD..............S.lPtQpl.KaQsPhRGppphhNssupWVshDsP-Pp.hRlpDstshTsQEppA.Lt.a+phGhl.st.s	....h.oQEcsD.ccPEEthAWAhh.s.LPtsu.G..ssu......lopPshhctWS+HLa-hGht.HsD.LcpLADEsGNIHVSpLPpQph.KaQsPhRGsRppa.NsA.ApWVspDsP-P..hRl.Ds+..pLTpQEppA.l.p..a+phGhI.s.......................................................	0	0	3	3
+10743	PF10911	DUF2717		Protein of unknown function (DUF2717)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as gene 6.5 protein however currently there is no known function.	25.00	25.00	29.70	29.30	19.90	18.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.68	0.72	-4.48	4	32	2009-01-15 18:05:59	2008-07-29 09:55:47	3	1	29	0	0	19	0	75.70	44	90.28	CHANGED	MLpPIp+hlpNPsDIPslPRAstEYLQVRaNtuYlhtSGhlstLRtsGaSEuaIAGFlpGLphA...SpslDEhE.lRKEQ	...........MLpPIpphhppPpDlPslPRustEYLQVcFNsuYhhtSGhlsth+ts.GhSEuaIhGFltGLtYA...SpllD-h-..hR+-.....	0	0	0	0
+10744	PF10912	DUF2700		Protein of unknown function (DUF2700)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Caenorhabditis elegans.	21.80	21.80	22.00	24.40	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.80	0.71	-4.20	6	52	2009-01-15 18:05:59	2008-07-29 09:57:19	3	4	5	0	52	47	0	136.20	22	65.64	CHANGED	lPARPLVssLulhGllRuhuphhhu.sshhpRlschhaLhLNLLLLFGAsKNstsALKWSQRlshhsVlLuVIpFMIaPVhFASasASG....h-pNtThh...clEplusKTp.Ec+..FVhGhLoGYslEFussLhIGlElLKYlLlNRLW	.................................hR.hlhhhuhhGlltshh...hhhs...ssh..h.t...h.....hs.hh..h..lhl..phllLaGshppsthsL+hupplshhsl..lls.hl.hhlhPVhhuShhASG............hpts..tsh.........p.....h..........s..t....ppp..........Fh.Ghh..Gh.hEhhhh................hhlsh.hhpahhlp.............................	1	8	11	52
+10745	PF10913	DUF2706		Protein of unknown function (DUF2706)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Rickettsia spp.	25.00	25.00	107.70	107.60	17.90	16.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.10	0.72	-4.37	2	39	2009-01-15 18:05:59	2008-07-29 09:59:14	3	1	39	0	4	15	0	58.70	90	99.87	CHANGED	MLK.hKhhllLIMLuQLLSCTPSAPYEIKSPCVus-IsDtuplshNPClRRPVNS.lsIs	MLKSLKhLLVLIMLAQLLSCTPSAPYEIKSPCVSADIDDGSSlSVNPCIRRPVNS.VNIV.	0	1	1	1
+10746	PF10914	DUF2781		Protein of unknown function (DUF2781)	Gunasekaran P, Mistry J	anon	Pfam-B_001738 (release 23.0)	Family	This is a eukaryotic family of uncharacterised proteins.  Some of the proteins in this family are annotated as membrane proteins.	21.20	21.20	21.30	21.20	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.98	0.71	-4.43	42	369	2009-01-15 18:05:59	2008-07-29 09:59:44	3	7	206	0	245	335	1	142.00	24	59.60	CHANGED	Dhlhhlaalhphshsh.....llDs..hhP....thh.t........htsltpaYlspapDhlh.....p.sPs.........ahpsh..................................hhhEhhaplPhhlhslY.................ulhps....sshhhshsLlauspsshophsplsphhh...............h.h..spctp..lltlYhPah.....llshlhslchhhpht	........................................................Dhhhhhahlhthshsl..................hhDh..h.hs..........lh.sh.........tpltphY.hpphpDhLhs.......sss...........ah+sh..................................hhhEhhapl.PhhhhuhY............................................ul..hts.........s.sah.shsllaustssp...sphspluthht...............hshthspc..tp..hlhsh.hsYh.....llPhllhhchhhp.......................................	0	57	107	171
+10747	PF10915	DUF2709		Protein of unknown function (DUF2709)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	23.00	23.00	25.00	386.50	21.20	22.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.39	0.70	-5.37	3	41	2009-01-15 18:05:59	2008-07-29 10:02:31	3	1	41	0	8	17	2	238.00	79	99.72	CHANGED	sVIosslKchLLQFLK+pKsAELLsTYLFFLEpKaQLQPVLFlRDKlIYQSAEDsIspLEcEGKLWRETEIpIusG+PuVNEpTKKIYICPFTGKVFGDNTHPNPQDAIYDWVSKCPENKERIuGlRVKRFFVSEDPEVIKoYI...KsRR-PIpKlVYSSuITGKLFsS+pAVIEDFK+SYLKsloLVEVQsQNKFKIEDsFLoFIQDpL-E-KIApFVEoLA-asEFcsYVcpWVEsE-	.MNISGSIKQKLLQFLcKQKuPELLATYLFYLEQuLpLsPVVFVRDKIIFKSsEDAIplLEtDKKIWRETEIQIoSGKPEVNEQTKRIYICPFTGKVFADNVYANPQDAIYDWLSSCPQNpERQSGVtVKRFLVSDDPEVI+sYI...VPPKEPIlKTVYASAlTGKLFHSLPsLlEDFcoSYLRPMTLEEVQNQNKFQLEoSFLoLLQDALEE-KIAEFVESLADDTAFHhYISQWVDTEE.	0	4	5	7
+10748	PF10916	DUF2712		Protein of unknown function (DUF2712)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillales.	21.70	21.70	21.80	22.50	19.40	21.60	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.93	0.71	-4.23	2	33	2009-09-10 14:58:50	2008-07-29 10:03:04	3	1	30	0	2	23	2	139.40	58	98.59	CHANGED	hppFhppNhRhlhAhslGl.lhAss.a.KAussNhtFchhl..shuNuhSsstaRpTopssNPWKVpLppSsEGKGTIhoFWL.h.stNpphspuSpIhNVKQGuts+YhtA.p.us+shshLAsENNNYsupoYhlDGlWDEETW	..............hppFhp+.hRLlhALVIGlLVF.APshH.SKAA..DNsIGFDFKLKPNCANSGSoSRYRETSSVNNPWKVRLcsSTEGKGTIASFWLGTYNKNKsAspGSsIMNVKQGAKT..RY.CGAYKVANKNTTYLAAENNNYNSKTYYVDGIWDEETW....	0	1	2	2
+10749	PF10917	DUF2708		Protein of unknown function (DUF2708)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Caenorhabditis elegans.	23.20	23.20	23.40	23.60	22.90	23.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.31	0.72	-4.16	6	26	2009-01-15 18:05:59	2008-07-29 10:04:11	3	2	5	0	26	18	0	43.70	55	53.18	CHANGED	MNhYSlFVFAlLuISuVo......ssG++Ct.GGNG.YGuG....VlIGAtK	...MNVYSVFl.FAlLAISSVS.......tG++Ct..GssG.YGuG.......s.....IlIGAtK.......	0	8	13	26
+10750	PF10918	DUF2718		Protein of unknown function (DUF2718)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	25.00	25.00	42.80	42.30	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.01	0.71	-4.11	4	13	2009-01-15 18:05:59	2008-07-29 10:04:30	3	1	12	0	0	8	0	124.50	54	96.89	CHANGED	MLCIFYLuRLCNLIIYSLYSLLMYPMpKLISFMFGELNPFc-VLPcscKKDD-ssl.........sIhPsEssslPpphP.plp-pt-pssls.pNs..................NGVFDFMKhPNPFKRY..YEYs.sYs.ppspspPp+Vp...cKuFlE+MlEMVE	MLCIFYlARLCNLIIYSlYSLLMaPMpKLISFMFGpLNPFsss.s.spKhpDshss..........htPh-sppIsp-hPLslh-ptppsshs..ss..................NGVFDFhKIPNPFK+Y..YEh....s.pNshKpPs.......KGhh-.MMphlE.....	0	0	0	0
+10752	PF10920	DUF2705		Protein of unknown function (DUF2705)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	46.40	45.90	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.79	0.70	-5.16	2	30	2009-01-15 18:05:59	2008-07-29 10:07:08	3	1	28	0	4	15	3	206.10	66	99.79	CHANGED	M+.pthhIhlVhhlF.tul...uas.shpshPhLDGhPluhus.h.hp.lLhWalPIluhSFhhSGsI+Dhh.SYt.LplsRpap+.hWlhpQFLhlhlhlllFT..QlAlhaIao.hShas.......st.FlhhhLhY.lhLhslFShQhhhELahcuQhA.L.IssYlIhSllhAchlhQ.sosph.aYhLlPNYu.GhRTGL..aopouThlIps.huLhIllll.lslhIlulhKFKphDhL	........MKNNKLIILVVIC..LFLQAILFMAFDFPFKTLPILDGFPVGLATPVVTRLLLYWYLPIIAFSFYISGNlKDLLSSYGFLQISRNaKKEYWLMKQFLKLhI+VILFTSLQLALIFIFTPYShas.......Tu.FlYLILGY.lMLFTIFSLQYLLELFIDAQKALLLINGYVIISILMADLIYQNTTVTWPYYLLLPNYGMGFRTGLI.FoNTSTlLIShPTSLIILLVVLLCVFIlAIKKFKTTDIL............	0	2	4	4
+10753	PF10921	DUF2710		Protein of unknown function (DUF2710)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacteriaceae.	26.20	26.20	26.20	27.40	23.60	26.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.26	0.72	-3.91	2	57	2009-01-15 18:05:59	2008-07-29 10:08:06	3	1	56	0	5	17	0	107.90	88	90.74	CHANGED	MVStssuRuE...LSD+DLVESVLR-LSEAADKWEALVsQAEsVTYSVDLGsV+AVANSDGRLLcLTLHPGVMTGYuHuELADRlNlAlsALR-EsEAENcARYGG.LQ	......MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETVTYSV..DLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRARYGGRLQ....	0	1	2	4
+10754	PF10922	DUF2745		Protein of unknown function (DUF2745)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	21.40	21.40	21.90	21.70	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.73	0.72	-4.07	4	21	2009-09-10 19:09:16	2008-07-29 10:09:42	3	1	18	0	0	15	0	87.50	50	98.76	CHANGED	MGRLYSGNLNAFKAAssRL.p.hDlsVhh--a.-phspppChp....LRlEDRuGpllsopTFpH+DEDVLaNhsTsWLN+hasQLKcWK	..MGRLYSGNLssFKsAssRLhc.hDl...sVhhEsap.ppsu+tChp....LRl.sRuGpll.sop..TFp..HpDEDVhhNhpT-WLp+haspLKcWK.	0	0	0	0
+10755	PF10923	DUF2791		P-loop Domain of unknown function (DUF2791)	Gunasekaran P, Mistry J	anon	Pfam-B_001611 (release 23.0)	Domain	This is a family of proteins found in archaea and bacteria. This domain contains a P-loop motif suggesting it binds to a nucleotide such as ATP.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.91	0.70	-5.87	28	286	2012-10-05 12:31:09	2008-07-29 10:10:10	3	3	243	0	96	309	63	370.90	34	90.05	CHANGED	Ips+cRssllsuL+uGVVP+hGLchIsVGRspElpALhp-l-plusGGuuFRhllGEYGuGKTFFlphlRshAhc+saVsucsDLoP.-+RLHustGpuculYpcLhcsLoT+T+PcGsALpsIl-+Wlsslpc-shspu.............sssEplIcp+Lutls-hstGa-FAplLcuYa+uptpG-Epl+susl+WL+GEass+s-A+psLGV+slIDDsuhY-aLKhluthl+puGasGLllslDElVNLhKlpsstsRppNYEplLpllNDshQG+s.sLGhlhuGTPpFl.DsRRGlaSYtALpSRLupstas.psuhp-hpuPhIRLssLo.E-lhlLhp+lRclaAtststp....thlsDptlpsFhcpssuRlGuphhlTPRphl+cFl.slLsll-QNPshchpclhstst..hss-	...............................................................................................l..+.tpsllpuL+uGV.VP+h.GlthltVGRptElpuLhp.D.l..-.h.l.s.c.G..Gu.u.FRhllGcYGoGKoFhLphlRphAhc+shVs....scsDLoP...-R.RLpustspu....hshYpELhpNluT+...s...cP-G.s.......ALt.ll-+alsphppp..shtps..............................ttscphIhphl.spl..s-..h.st.Ga-FA.pllptYhc....u.....h.ps......c-ph+.st....sl+WlRGEhss+o-A+.....p...tLG...V.c.t.lIsD..s..sh.Y-hLKhhutFl+tuGYsGLllhlDEhV.N.l.a.K.......ls.......s..s.sRptNY..EplLphhN..DshQGp.spt.LshlhuGTPphl.......DtR+G.laSYpALps......RLupsp.......hs.....p.....sshh-h.uPsl+.L..t..sL.....o..sE-..hh.hLhp+ltclaAtt.s.p........hhls-pt.l.ttFhpttht+lGsth.hhTPRphl+sFl.plLsll.Qssshshpplhtt..h..t..........................................................................	0	40	67	83
+10756	PF10924	DUF2711		Protein of unknown function (DUF2711)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as ywbB however currently there is no known function.	21.20	21.20	23.20	26.20	20.20	20.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.47	0.70	-4.86	6	65	2009-09-10 23:06:20	2008-07-29 10:12:01	3	1	63	0	5	62	1	198.10	52	90.20	CHANGED	-cSPILtQLPpsFpSAAlLLHPFlpMPhGWEsuhRKpsYEHI.YPSsEEIlphG+sVSWpcVMossGLpShsELAlAlhTuIsA..LR-EYtRcDLAc+LasslctDLYYPoEDhTSlFLltsLLKVLGSKGAcslYYuEPIh-scGshpls-ssPhslhsLssuElIITDEphDaAFMSlaDSFoTLFLAK-psIccIlpuhshEAlICscsThIsWYh	............-cSPILpQlPtpapSAAILhpPFlQMP.GWEcuhRKpPYEHI.YPSsEEIIppGKuVSWKchMShoGL+SaA-LAhAh.hTSIuA..hp-EYpRcDLAE.+LasN..l.+.p.D.LYYPoED.aTShFLlppLLKlLGSKGucplYaS.EPIh-ssGlLplssToshD.lhDlu.ss.ELIITsEcp-aAFMSlYDSFsTLlLAK-cNIc.lVpuMNhEAlICDccThIsWY...............................................................	1	1	4	4
+10757	PF10925	DUF2680		Protein of unknown function (DUF2680)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as yckD however currently no function is known.	23.90	23.90	24.10	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.76	0.72	-4.10	14	166	2009-01-15 18:05:59	2008-07-29 10:13:36	3	4	89	0	53	148	1	60.30	27	44.87	CHANGED	LT-pQKp-IpsLtpQlh-lpKpllsKaVchGllTp-Qu-pIKppIDpthphh....cpN...........GFhP	..................tplpshppphhph+KphlsKhVctGhlTp-QA-pI+ppl-pphphh....pps...........sh...........................	0	30	43	50
+10758	PF10926	DUF2800		Protein of unknown function (DUF2800)	Gunasekaran P, Mistry J	anon	Pfam-B_001630 (release 23.0)	Family	This is a family of uncharacterised proteins found in bacteria and viruses. Some members of this family are annotated as being Phi APSE P51-like proteins.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.37	0.70	-5.34	27	496	2012-10-11 20:44:46	2008-07-29 10:43:57	3	3	403	0	62	832	284	331.50	38	92.63	CHANGED	HAhLSsSuu+RWLpCPsSst.LppphsDpsSshAp.EGTsAHtluEhtL.............pptl.cshshhs..........hs.....................tt.hhs-EMt-hsptYl-hVhEphp.h.....sshlhlEQRlchuphlP-......uFGTuDslllu..ss...hLpIl.DhKYG+G.V.VsA...................ppNsQhhlYALGAlc.ashlYD.hcpVphsIhQPRh...cs.hSsap..lssp....-LhpWupphlcstAphA..............tspucapsGcaC.pFC+s+.ssCpARActshpls.ph-Fpsssh............................Losp-lup....lLsphs.lcpWsc-lcshAhpphhs.Gcph...sG..aKlVpGR.usR+as.D-csltpsLpstGhtpp.lYp.pcLlo.TphEKhh.....sc...........cpascll.tshlh+ssGKssLsspoD+RPul	....................................................................................................................HAhLSASuu++WLpCP..s...S........hp....h..p...p..t.h...s..-..p...s....S.....aA..t..EGThAHt.L...uEh..hl...................ptth...pt..st.h...............hs....................................................................p.thhs.c..E......M......t.....c......h..s.....c..t...Y.....s...s..h...V....-hh...pth........................sshhh..l...E...p....+..lDh..uc.aVsp....................uFGTuDslI.lu..........ss.......hLpIl..DLKYGpG...l....V..s..A...................t.pN..s...Q.hh..LY....A.L......G.....A.h.....c.....h....a....s..h.....l......Y.......D.......hcp........Vp......h....T.....I......h.....QP..Rh..............ss...hS.s.h.p...ls..hp.........c..L.h..p.W...upp..hlc...s..tAphA.................................htGpG..ca....ps......G...p...a..C..pFC+h+...sp...C+sRAch.hpls...p...ph.psPth......................................................Losp-luc.....lL.phstlppWsp-....lcpaA....h....s....pAhp....Gc.ph...sG....aK..L.V..EG..R.SpRtas...Dppsshp.h.l.h.p..sGa...cs...hhc....pcLlolTphEKLl......GK...........+tFsclh..tshI.KPpG..K.oLssp.oD+RPsh.................................................................................................	0	28	52	60
+10759	PF10927	DUF2738		Protein of unknown function (DUF2738)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	20.30	20.30	20.50	20.50	18.70	19.90	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.68	0.70	-5.32	6	39	2009-01-15 18:05:59	2008-07-29 10:44:37	3	2	27	0	12	40	35	219.30	26	63.81	CHANGED	ssshphp+hhFsKs.hascltsuH......RINl+Y-ccsshs..PLsh+TslLFSFGlpp.sshQDpsc.sYShsLsha-tp.GPospEptahshLpplts+s+cHL+c.sl++shs.....Kh.hssLhssMsshYhKhp-sls..........sPs+uPsLYPKllhut+ss.phsT..hFaKcscGpslpIs....llpp+C+Vlssltl-SIFlGsKsSlQlKlh-VllsE.........sls.p++plhhsphPss.ppE.p+csssssE--Lspp...tp.Ecl	..............................................s...................tss+......hlslpYcpp...t..PLhl..pss..hha.S.FGlps.s.....ohpsuss..saShsLhh..h.shp...s.sspEs.sFhpslctIts+s+cal.hc.s.+csht..........Kh......p.cslh-hh....p.....h.hhpp.t-sh...........sPscsPthYs...KLlhsppss.chhT...hhhp.sctptlch........hltt+spshsslth-Sl.a.h..s..sK.uhQhKL.psll..hE..........ht.............................................pt...........................................	0	12	12	12
+10760	PF10928	DUF2810		Protein of unknown function (DUF2810)	Gunasekaran P, Mistry J	anon	Pfam-B_001682 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	32.00	38.80	18.40	16.90	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.35	0.72	-4.23	12	654	2009-01-15 18:05:59	2008-07-29 10:46:18	3	2	649	1	55	192	7	53.90	79	45.01	CHANGED	plpsLsFsRslTKAEQADMGKLKKSV+GLVVVHPMTALGREhGlcpVTGaAP+t	......KLMcMPFpRAITKKEQADMGKLKKSVRGLVVVHPMTALGREMGLpEMTGFuKo.s.	0	3	12	34
+10761	PF10929	DUF2811		Protein of unknown function (DUF2811)	Gunasekaran P, Mistry J	anon	Pfam-B_001693 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	20.90	20.90	21.60	24.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.90	0.72	-3.96	31	108	2009-01-15 18:05:59	2008-07-29 10:46:54	3	2	64	0	50	111	199	58.20	47	69.16	CHANGED	ShpsElPEsLtpuMppFI-sHPsWDQYRlhpAALAsFLlQN.G........sssRsloRhYlssLF	..Sl.sElPEsLapuhpsal-sHPsWDQ.RlhsAALutFLlQN.G........ss..sRslsRlYLssLF..........	0	6	29	46
+10762	PF10930	DUF2737		Protein of unknown function (DUF2737)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	46.10	47.40	16.30	14.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.85	0.72	-4.36	5	174	2009-09-11 15:20:40	2008-07-29 10:47:25	3	1	162	0	1	62	0	54.20	81	99.29	CHANGED	M..RGLSYNPuILPoEhI...IR++hKPMPo..REELLKRNSFPSVNcNKYLNAMLRKs..KK	...MRGLAYNPGILPAEMI...IRQRsKPMPS..REELLKRpSFPSVNpNKYLNAMhRSG.KK....	0	0	0	1
+10763	PF10931	DUF2735		Protein of unknown function (DUF2735)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as glutamine synthetase translation inhibitor however this function can not be confirmed.	25.00	25.00	31.20	29.30	23.40	21.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.53	0.72	-3.72	11	50	2009-01-15 18:05:59	2008-07-29 10:47:42	3	1	50	0	27	53	0	51.00	37	76.29	CHANGED	SA+IYQFPl..GGRsGhsp+p...tth.spttssssssslssuSWYH--AlpE-ps	............SApIYQFPl..uuRtuhsppc...pst.spptuss.hssssssuuWYH--AlpEpp..	0	4	10	15
+10764	PF10932	DUF2783		Protein of unknown function (DUF2783)	Gunasekaran P, Mistry J	anon	Pfam-B_001590 (release 23.0)	Family	This is a bacterial family of uncharacterised protein.	19.80	19.80	20.00	22.60	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.81	0.72	-4.48	27	179	2009-01-15 18:05:59	2008-07-29 10:48:18	3	1	165	0	68	159	43	60.50	54	83.47	CHANGED	LspsPNlssP...........DsFYptLIssHcsLo--pSptlNARLILLLANHIGDhsVLpcAlphA+pu	..................LsTpsNl.scP...........DsFYEALI-sHRsLo-ppSphlNA+LlLLLANHIGDhsVL+EAlshARp.s..	0	10	32	49
+10765	PF10933	DUF2827		Protein of unknown function (DUF2827)	Gunasekaran P, Mistry J	anon	Pfam-B_001771 (release 23.0)	Family	This is a family of uncharacterised proteins found in Burkholderia.	25.00	25.00	25.40	25.30	21.20	23.60	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.19	0.70	-5.98	9	211	2009-01-15 18:05:59	2008-07-29 10:49:20	3	4	68	0	56	172	41	347.10	44	93.20	CHANGED	plGIolhl.RsssQSlW.NGItQNslaLshLLppSPhltcVslVNssDs.shssuL.hsthssslhshs-stcphDVlIEhuuQlss-ahchh+tRGsKlVohpsGs-YVhshEshhFs+s..shlFpsssYDplWslPpht+oshsaLpolhRuPVphVPalWcPhFl-pptpsL.ttG.tFGY+P.......G+.sthRlolhEPNIsVVKsslhPMLlu-pAYRtpP-hlcal+VsNoh+h.+-pPpFVthApuLDlVRcG+soF-uRashspFhApasDsVVSHpWENs.NYlYaDlLaGGYPLVHNSshLsDsGYYYPD.DspsGApsLh+AhpcHDsch-sYpp+uRshLtslsstsstNlutYsstLs	...................................lGIolhl.Rs.spulWtNGIpQNslaLshLLcpSshltcVhhVN.s.G..ss....sh..ssuL.hst.hsls.lhshs-s.hc.plDVlIEhuuQlss-ahpth+s+GsKlVshpsGp-YlhshEshlFs+ss..uplFsussaDtVWslPphtposhsaLpolhRuPVplVPalWsPhFl-+tttpL....t.tGhpFGYcP..........G+...tthRlohhEPNlsVVKoshhPMLls-EAYRtpPDhlpalaVsNoh+h.K-cssFVpF.s.p.sLDlV+puhsoF-sRashspFhApa.s.DsVVSHpWENs.NY.hYaDlLYGGYPLVHNSshLs..c..sGYYYPDFDstsGu+sLhcA.hccHDsph-sYpp+ucclLcplo.tNstNlstYsptl.h..........	0	14	17	36
+10766	PF10934	DUF2634		Protein of unknown function (DUF2634)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as phage related, xkdS however currently there is no known function.	31.80	31.80	32.00	32.00	31.60	31.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.25	0.71	-4.30	26	250	2009-09-11 16:39:40	2008-07-29 10:53:59	3	2	179	0	57	234	7	109.00	29	77.38	CHANGED	oYplcFppschhsp.......l-slEAl+QhlhhsLpT-Raca..IY....SpsYG.sElpsLIGp..hspshhcsElpRhlpEALlhcs+IpsVcsFph.phpsspl..plsFsVhTh.Gph	...................pathDhcps..chhtp..........l-sh.EAl+QhlhKsLpTcRac......a..IY........opsYG.sElp.c.LlGp...spshhcsElpRhIcEALhh-s..RIpsVssFph...ph.p...t...c.sl..plsFsVpohhGp...............................	0	27	49	51
+10767	PF10935	DUF2637		Protein of unknown function (DUF2637)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	22.80	22.80	23.10	22.90	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.29	35	337	2009-01-15 18:05:59	2008-07-29 10:56:07	3	7	169	0	121	387	2	142.20	20	43.45	CHANGED	tsshshshslussuaslS.F..suL+clAhttu.hsst..hualhPlslDusllsuohhhlhh...tpssttt+hhsashhshu..........................................suhSlsuslhashhssts..pt...t.t.............hlthhhhhl....sPlthhssh+h......h.h.......hhtpshss	..................h.hshssshsluslAhslS..a.......suLpslAhp...tG...hssh..............huahhPlslDuslhssshhhlhh....ht....h..s.h...h...hh....phh.sWhh...h....ss..u..................................................sshs.lsusl..h.ashhhtth..ph......................hh.hhhh............ssh.hhh.h.....h....................t.t..........................................................................................................................................................................	0	33	90	114
+10768	PF10936	DUF2617		Protein of unknown function DUF2617	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.  	19.50	19.50	19.70	19.80	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.05	0.71	-4.68	15	185	2009-01-15 18:05:59	2008-07-29 10:57:39	3	1	180	0	42	119	0	142.50	39	95.31	CHANGED	hhppLsss.sDsuAusLuluLsusssssLAstclsh..ssuslpLsVLGASHtVslptss.uphsEpVuChssss....tsLPs.....psp.usGYchpopscslstucFpspAssLpscssccssuLsGsFPG-.stAlTALsAcss......ss..uhpW+TWHlY...Pps..GplVsT+S+hc...P	..............................hhpLths.sDspus.LuhsL.....s.t.s...sLAshcl...th.........sus..........tlpLsVLGASH.Vslct.........t...up...hsEpVuChstss.....ssLPt..................shp.s.t....Ychtuc.s...cshs.........ts.sFtthApcLht.......hs..s..c.....t.....st....hLsGsF.PGs....st...AlTAl...hup.p...............ts....thpW+TWHhYPpt...........GplVtTpoph......	0	12	29	39
+10769	PF10937	DUF2638		Protein of unknown function (DUF2638)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	22.00	22.00	22.10	22.00	21.00	21.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.73	0.71	-3.05	16	190	2009-01-15 18:05:59	2008-07-29 10:58:45	3	5	164	0	134	177	0	92.30	28	77.69	CHANGED	sPhI+FlGpRp..sppsspsstsHPsossshlP.........suhuuappphppasPhp......pss..tu..ustsuuuhusl......pPhp.GEhhshs-LPsRF+.ppPhsEAElEuIpoG.GA	...........................................................................I+FhG....................t..tts...sHPhsss.t.hs.................t.h..h.....h.t...P................t................tth.us.ps.uss.sss....................pshp..sphhsht-LPtRF+...R...ps...h..sptElEsIpoGGs..........	0	35	67	108
+10770	PF10938	YfdX		YfdX protein	Bateman A	anon	Bateman A	Family	YfdX is a protein found in Proteobacteria of unknown function. The protein coding for this gene is regulated by EvgA in E. coli [1].	22.60	22.60	23.00	23.40	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.98	0.71	-4.56	23	564	2009-01-15 18:05:59	2008-07-29 11:02:18	3	2	501	4	62	218	7	153.00	55	68.75	CHANGED	pAlpclppAttAlps.GpscpAhptlpcApuplchhtsc.sphs...t...................................hlPVsspltlh-t.hssssptcsulppApptlppGchptAhchLchhss-lshshshlPLsph.sulppAtpLLcpsKhpEAstsLptAh.solVlsp.shs	.................................AMRDlQhARhALFc.GDs-..KAKcLss-AouLLsDDST-WsKFAKssKKsslssD...........................pYIsINuSlsluEs.Y....ls..TPEKcAAIchANEKMs+GDKKGAhEpL+LAGVuVhENQhLhPLcQTRsAlscAp+LLDcppYYEAsLALKuAc.DGIIVDSpu..l......................	1	20	43	52
+10771	PF10939	DUF2631		Protein of unknown function (DUF2631)   	Pollington J, Finn RD	anon	PRODOM	Family	This is s bacterial family of proteins with unknown function.	25.00	25.00	28.30	27.90	18.00	16.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.25	0.72	-4.13	13	179	2009-01-15 18:05:59	2008-07-29 11:51:58	3	1	177	0	44	115	0	66.90	47	58.98	CHANGED	hAuTElEhasG.......VDst-VPSAsWGWSphshRshpIuGlluuhFLLsMlhGNHpG........+VEDhaLIGF.AA	...................tsptsEhasG.................V-.T......t-sPSAAWG..Wpp.....lspRshpIsGhhssh.FLLuM.l.hGNHpG........HVEslaLlsFAs.........	0	11	33	41
+10772	PF10940	DUF2618		Protein of unknown function (DUF2618)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function. The sequences within the family are highly conserved.	25.00	25.00	35.90	35.50	18.40	16.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.16	0.72	-4.18	3	84	2009-01-15 18:05:59	2008-07-29 11:52:30	3	1	84	0	9	19	0	34.40	68	89.18	CHANGED	KGRSIMAHIRRTRHIMMPSYRSCFSYSlFsSQ.SoSHhAL	.......ts+IMAHIRRTRHIMMPSHRshFDaSFFst.........h.....	0	2	2	5
+10773	PF10941	DUF2620		Protein of unknown function DUF2620	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	25.00	25.00	35.00	43.10	23.90	23.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.41	0.71	-4.06	12	324	2009-01-15 18:05:59	2008-07-29 11:54:02	3	1	316	0	27	96	0	113.90	80	97.87	CHANGED	h+IsIGGtlpKcpIcchlcch.ussphpshlhuDh-AAMtVKsGphDYYlGACpTGuGGALAMAIAllGhs+ssTIuhPut.spcEcIcphVspGKhAFGFTs-HhEpAlshLlshLh	...KKIGVAG.LQREQIKKTIEAT.APGsF.E.VFIHNDMEAAMKVKSGQLDYYIGACNTGAGAALS.......IAIAVIGYNKSCTIAKPG.IKAKDEHIAKMIAEGK.VAFGLSVEHVEHAIPMLINHLK.....	0	7	12	21
+10774	PF10942	DUF2619		Protein of unknown function (DUF2619)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	55.20	55.00	19.60	17.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.91	0.72	-4.03	15	172	2009-01-15 18:05:59	2008-07-29 11:56:57	3	1	170	0	42	92	0	69.00	58	71.95	CHANGED	RlLSusIEloAAlLML+hNDlcKAltINulLAlVGPsIhIlohoIGLhulAu+lShsKLlhIhhGVsLI	RLhSGShEIhAALLMLhlNDs+KALhINuhL.AhVGPTVLIlTMTIGIsulA.uclSahKLhalslGlsCI.	0	19	34	37
+10775	PF10943	DUF2632		Protein of unknown function (DUF2632)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of membrane proteins with unknown function.	25.00	25.00	290.30	290.10	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.52	0.70	-4.85	2	43	2009-01-15 18:05:59	2008-07-29 11:58:42	3	1	4	0	0	24	0	180.40	93	100.00	CHANGED	MF-TNaWPFPDQAPsPFpAQl-pLouTENVYIFLTTLFGILQLVYVhFKLLCTMFPoLHFSPIWRGLENFWLFLSLsSLAIAYWWLPSMTFTGYWALTlIATILVhlhLIMMFVKFlNFVKLFYRTGSFAIAIRGPIVLVALDVTIKLHCTPFAILVKElGsIFYLSEYCNKPLsAAQIAAL+ICVNGQWFAYTRSSTTSAA+VAAANSTAKYHLFlLQGVA-YTQLSSVKFE	......................EQLSSTENVYIFLTTLFGILQLVYVhFKLLCTMFPsLHaSPIWRGLENFWLFLSLsSLAIAYWWLPSMTFTGYWALTlIATILVLlMLIMMFVKFlsFVpLFYRTGSFAIAIRGPIVLVALDVTIKLHCTPFAILVKEVGNIFYLSEYCNKPLsAAQlAAL+ICV.................................................	0	0	0	0
+10776	PF10944	DUF2630		Protein of unknown function (DUF2630)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins have no known function.	21.10	21.10	21.20	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.86	0.72	-3.88	14	143	2009-01-15 18:05:59	2008-07-29 11:59:06	3	2	141	0	52	97	1	79.40	54	94.45	CHANGED	ssDp-ILsplpcLVsEE+cLRpphppGcIDpupE+p.RLpplEspLDQCWDLLRQRRAhRsuGpDPD-ApsRPsspVEsYhp	.....s.sDp-hLu+Ic-LVAEE+tLRuphppGtIspsEE.pp.RLRclElcLDQCWDLLRQRRAhRpsGsDPc-AtVRPsspVEGYp........	0	15	37	49
+10777	PF10945	DUF2629		Protein of unknown function (DUF2629)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as yhjR however currently no function is known.	20.80	20.80	20.90	22.50	18.90	20.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.32	0.72	-4.61	7	472	2009-01-15 18:05:59	2008-07-29 11:59:37	3	1	469	0	27	83	0	43.90	84	69.07	CHANGED	phQsDhhALSQAFSLP-lsYtDISppEpLstAltRWPLLAEhAc	...............h.FQNDIlALKQAFSLP-IDYADISQREQLAAALKRWPLLAEFAQ..	1	3	6	17
+10778	PF10946	DUF2625		Protein of unknown function DUF2625	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as ybfG however currently no function is known.	19.90	19.90	20.50	20.10	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.29	0.70	-5.39	12	157	2009-01-15 18:05:59	2008-07-29 12:00:21	3	1	150	0	24	112	2	191.50	47	90.87	CHANGED	Lc-Llshc-sAWsllp-WhspApN+hElLss.sspAppsLhsLQVoTRSshGAllYpoGGllIDtGWLRlLGSGp.+LsRslssWNtG+.tht..hptssaLLlADDslGGaFAlNGGuLG.....-csGplYYaAPDoLpWEsLplGYS-FLtWslsscLscFYcsLRWpsWps-VtpLsucps.asFhPhLWspps...slctpS+csVslpEha	........hppLls.-cSAW.llppWlpsApN+sElLsss.ps.tA.c.psLhphQloT+SPMGAllYpoGGlLIDpGWLRIhG..SGp.+.LP...Rshhs...WN.t....pFs......tsphLllADDVhGGhFAlNG.....GsLG.....ccsGplYYauPDoLpWEsLpluYSEFLtWALsGDL-sFYpslRWpsWp-DVtpLsusps.asFhP.La.ppt.....-tpp+p.lslppha....................	1	7	15	23
+10779	PF10947	DUF2628		Protein of unknown function (DUF2628)    	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as yigF however currently no function is known.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.68	0.72	-4.25	71	909	2009-01-15 18:05:59	2008-07-29 12:40:52	3	16	750	0	179	662	139	105.40	19	55.47	CHANGED	hshashhp....sts..............ttts................ththlp.pG..........asa..hAahF..uhh.........ahhhp+hW....hhs.hshlslslshslhhhhh............s.shhh..................hltlhl....slhhGhpusth...hhhcht+	...........................................................................................pt.....................ththhc..u...................asa..hAhhF..shh.........ahhh++h..W............hhu...hhhhhl.sl.shs.l..lshhht.......................hhh..............................................................hltlhl....tlhhuh.uNth....ahpph....................................................	0	41	96	128
+10780	PF10948	DUF2635		Protein of unknown function (DUF2635)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of phage proteins with unknown function.	20.10	20.10	20.40	20.10	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.29	0.72	-4.66	20	259	2009-01-15 18:05:59	2008-07-29 12:43:16	3	1	235	0	33	149	2	46.20	45	73.56	CHANGED	lKPAp.G....hsV+DPptGchLss-GcpVscsu.aWhRRLpDGDVlhspsps	.........................lKPst..G......+sV.DP....sp........uchL..PsEGc...pVscss.aWhRRhssGDlhplspp.s....	0	4	11	25
+10781	PF10949	DUF2777		Protein of unknown function (DUF2777)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus cereus.	25.00	25.00	69.00	68.20	22.20	18.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-10.88	0.71	-4.61	10	135	2009-01-15 18:05:59	2008-07-29 12:51:55	3	1	134	0	21	80	0	182.20	56	96.18	CHANGED	Ms....pR..pphLhppsRpashGTl.hIc-pasFh--EEs-thLlEslspsslElhcsscWppuphh.-pshlppusEphsLpsGEpIRhcKpLthuhhpLLs-LsDssFhtFlspLpSLGaSlYDClaCaNtLsF.......spppsspGVNFlpFsN--tlCulQHHasRtpsps......DRFEaTtusGcRhlhpps	..............M...hQR..KHILYNQPRAHTlGNVEYINNEWlFF.DDEN-EAFLLE-IAEDGFEILYNNNWLPARFY.EQslL.QIAsEQHpLQNGEMIRIRKKLLLSYpEWLEELPDSlFsLLTEsLQSL+YSLYDChYCHNaLSFL......PcEEssEGVNlLLFDN-EMICoLQHHFVR+soSNK.....NhFcFTKsNGEcLHI-u.T...	0	4	13	15
+10782	PF10950	DUF2775		Protein of unknown function (DUF2775)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	22.50	22.50	25.40	22.70	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.75	0.72	-3.83	8	136	2009-01-15 18:05:59	2008-07-29 12:54:08	3	9	11	0	35	126	0	76.40	38	100.80	CHANGED	pDlt.YW+hlMKDpDMPEtIpuLLs.p......phcs.pph..t..........pctulc-FEPRPpho..sYssN-lchpEKKpslc-FEP+PNlSAYGDN-IctpEK.KsslpDFEPRPNlSAYs	...................................................................................pph-sh....sslo...tYs-spl.cspp.ppp..hscDFEPRPNlotY.sDt..hchcpp.pshs............cDFEPRPslotYs..................	0	0	31	35
+10783	PF10951	DUF2776		Protein of unknown function (DUF2776)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.90	20.90	21.10	83.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.46	0.70	-5.39	7	355	2009-01-15 18:05:59	2008-07-29 12:55:53	3	1	344	0	11	142	0	329.40	81	98.46	CHANGED	MNYGISlLFRAIPLlMulhChuYGuFlhp.Gss..usthVAG.VlhSLuhICIALFsTAATIIRQlI+sYNphhpahLPllGYLuAslThlhGhsh.hspusssusFVAGHVlhGVGhIsACVATsAsuSTRFoLIPtNucss.ssthPtsAFopttuhhLIslsllholluaIWuahLLuco-ppss.aVAGHVhhGLAsICsSLIALVATIsRQlRNsaoc+ERhhWsthVllMGSIolLhGlaVL.usosssphusGYIhIGLGLVCYSISSKVlLLAtlWR+chKLANRIPLIPVhTALACLFLuAFLhEhusscssYFIPARVLsGLGAICFTLFSIVSILESGTS	......MNIYIGWLFKLIPLlMGLICIALGGFVLESSGQ..SEYFVAGHVLISLAAICLALFTTAFIIISQLTRGVNTFYNTLFPIIGYAGSIITMIWGWALLAGNDVMADEFVAGHVIFGVGMIAACVSTVAASSGHFLLIPKNAAGSKSDGTPVQAYSSLIGNCLIAVPVLLTLLGFIWSITLLRSADITPH.YVAGHVLLGLTAICACLIGLVATIVHQTRNTFSoKEHWLWCYWVIhLGSITVLQGIYVLVSSDASARLAPGIILICLGMICYSIFSKVWLLALVWRRTCSLANRIPMIPVFTCLFCLFLASFLAEMAQTDMGYFIPSRVLVGLGAVCFTLFSIVSILEAGSA.........	2	5	7	9
+10784	PF10952	DUF2753		Protein of unknown function (DUF2753)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	27.10	27.10	27.10	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.88	0.71	-4.19	7	99	2009-09-11 03:22:03	2008-07-29 13:02:31	3	2	99	0	15	59	2	134.70	69	95.28	CHANGED	WE+HTLLA-pAhppss.htoIlHYQ.ALu.Sppl...psspt-L-DhlslpVlSCHNLApFWRttGDscYELKYLQLASEpVhsLlPQCPpppC-uFlsoLGCCpuALl-FhKRHPNPtIA+plpcIsosspCELIApF+Lp	....................................WE+HTLLADhAhQ-sDHLRSILHYQQALTlSppl..sEu-EI-hEDRhhISVISCHNhApFWRshGDspYELKYLQLASE+VLTLIPQ...C.pssCEAFlDSLGCC+KALlDFMKRHPNPcIA+hVQ+IDTAopCElIApFRLN..............................	0	1	4	8
+10785	PF10953	DUF2754		Protein of unknown function (DUF2754)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Enterobacteriaceae.	25.00	25.00	91.90	91.80	24.10	19.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.57	0.72	-3.92	3	443	2009-01-15 18:05:59	2008-07-29 13:05:01	3	1	440	0	15	74	1	70.00	90	92.22	CHANGED	MpLosKIRRDWHYYAVALGLIFILNGVVGLLGFEAKGWQTYAVGLVTWVISFWIAGFIIRRRPEEopsAE	MNLPVKIRRDWHYYAFAIGLIFILNGVVGLLGFEAKGWQTYAVGLVTWVISFWLAGLIIRRRDEETENAQ.......	0	1	1	8
+10786	PF10954	DUF2755		Protein of unknown function (DUF2755)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as YaiY however no function is known. The family appears to be restricted to Enterobacteriaceae.	25.00	25.00	90.60	90.60	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.33	0.72	-4.29	6	443	2009-01-15 18:05:59	2008-07-29 13:09:54	3	1	440	0	15	59	2	100.70	89	98.89	CHANGED	MADFTLSKSLFuGK.RssSSTPGNIAYALFVLFCFWAGAQLLNlLVHAPGVYE+LMQsQ-TGRPRV-IGLGVGTIFGLlPFLsGClIhuVlAlhLRWR+R+	............MADFTLSKS.LFS.GKYRNASSTPGNIAYALFVLFCFWAGAQLLNLLVHAPGVYERLMQ..VQETGRPRVEIGLGVGTIFGLIPFLVGCLIFAVVALWLHWRHRR.	0	1	1	8
+10787	PF10955	DUF2757		Protein of unknown function (DUF2757)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as YabK however currently no function is known.	22.50	22.50	23.10	34.70	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.75	0.72	-3.79	8	173	2009-01-15 18:05:59	2008-07-29 13:10:27	3	1	173	0	32	85	1	72.70	56	99.25	CHANGED	MAlaYaCRHCGhcVGoLspsslpo.-pLGFacLT-cE+sDMIoYcpNGDlHVKTICEDCQEuLpcNP-YHpacpFIQ	.....MthaYYCRHCGspVGSlsu..pp....Vho.-sL..apLTEpEhs-MIpa+E.NGs.I.alKTICEpCQEsLss.PEYaEY-pFlQ..........	0	10	22	24
+10788	PF10956	DUF2756		Protein of unknown function (DUF2756)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated yhhA however currently no function is known. The family appears to be restricted to Enterobacteriaceae.	20.70	20.70	21.40	31.10	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.61	0.72	-3.78	5	476	2009-01-15 18:05:59	2008-07-29 13:14:17	3	2	469	0	27	111	1	101.90	81	74.37	CHANGED	MKRLLlLAALLPFuuLAQPINThNNPNQPGYQIPSQQRMQTQMQTQQlQQKGMLNQQLpTQTRLQQQHLQoQlNNNsQRVQQGQPGphN.sRQQVLPNTNGGMLs	.......MKR.LLl.LTALLPF...VG...FA..QPINTLNNPNQPGYQ..IPSQQRMQTQMQTQQIQQKGMLNQQLKTQTQLQQQHLENQINNNSQRVLQSQPGERNPARQQMLPN.TNGGMLN........	0	1	3	15
+10789	PF10957	DUF2758		Protein of unknown function (DUF2758)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	20.50	20.50	20.60	20.60	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.93	0.72	-4.15	7	170	2009-09-11 11:48:29	2008-07-29 13:15:39	3	1	166	0	16	74	3	59.30	56	94.78	CHANGED	MlKVtVFDcEHEKDLpp-lNpFLKplc-spllDIKYsVAAh.p-s-tEQlYCFSAhIlY+p	..............Ml+VKVF..DEpH.E...K...DL..E...DAVNsFL.KK.IcDs..phVDIKYQ..Vuso...hss...--sQIY.CF.SAMIlY+s.................	1	1	8	10
+10790	PF10958	DUF2759		Protein of unknown function (DUF2759)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillaceae.	20.70	20.70	21.30	23.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.57	0.72	-4.38	11	150	2009-01-15 18:05:59	2008-07-29 13:16:40	3	1	147	0	29	71	0	51.80	62	84.06	CHANGED	IFuLVolLAlaGslRuLKcKNlLullFuuuohhVFGWFoIMTllasGaP.ssH	.......IFsLV.TLLAVFATLRTL..RE..KNhLAsGFAlATVLVFGWFTIMTVLasGYP.sA.s........	0	8	20	23
+10791	PF10959	DUF2761		Protein of unknown function (DUF2761)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as KleF however no function is known.	25.00	25.00	26.40	92.20	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.07	0.72	-4.36	5	34	2009-01-15 18:05:59	2008-07-29 13:22:50	3	1	21	0	4	19	1	92.10	78	70.28	CHANGED	PYPPGFVCPsTGRVAVLVRDYAsSDLNGDAPAYWYSAQSEEWGLDPWRLVEGVDPHTpGGSaDVCFAsGSoRTVGPLMTFFL..uAuDAARLsA+cGc	.PYPPGFVEPoTGRVAVLVR-YAsSDLNGDAPAYWYSAQSEEWGLDPWRLVEGVDPHstGGSFDVCFAsGuoRTVGPLMTFFL..SAucAApLsstc.s...	0	0	1	3
+10792	PF10960	DUF2762		Protein of unknown function (DUF2762)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as holin-like protein BhlA however this cannot be confirmed.	22.60	22.60	22.90	22.70	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.44	0.72	-4.27	14	187	2009-01-15 18:05:59	2008-07-29 13:23:53	3	1	139	0	26	134	0	71.30	32	92.17	CHANGED	M.Ep-llplhhoQGhaAlLFshLLFYlLKpsc......................EREp+YQplIpc....lT-pLshlpshtccVp-hhp+	...................tlhphhhoQGsaAsL...FlhLLF....alhKpsc..........................cREc+hQphI-+....hs.-phpslp....c....hhp-lpch.t...............................	0	11	24	26
+10793	PF10961	DUF2763		Protein of unknown function (DUF2763)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	21.60	21.60	21.90	22.30	21.10	21.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.16	0.72	-3.59	10	138	2009-09-10 16:34:48	2008-07-29 13:24:32	3	3	107	0	90	143	0	89.80	34	86.04	CHANGED	VYlSs.GsVh-.ppRSPWRLShlsDFFhGllsFIshFFpTlls.ssscstppssuusp+ascGtGssGsssGtpthGpIs+GuGPsssP..hGG	......................sYlsp.GpVh-....pposWRLuhIsDhFaGIhpFlhhF.FpTlls..............ssscp......tp.h.s.s.......s..s.sp.....c....a.....s.s.....Gt..Gs....sG.s.....s........stthGths.th..tGst......................................	0	27	43	67
+10794	PF10962	DUF2764		Protein of unknown function (DUF2764)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.50	20.50	20.90	20.50	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.56	0.70	-5.17	10	168	2009-01-15 18:05:59	2008-07-29 13:25:16	3	2	164	0	42	131	10	218.90	28	88.05	CHANGED	MopYYaLluGLPslslEDsKLsYols-FcsELtssLSccDpKLIDLhhhcFDNtNlLtahcss-stscscGp...lop-Elsshlush+-u-....sscaPsYFp-FlppYht..................psucEp......lsaEDcLuAhYYsYAMcsuNcFlpsWFpFNLslpNILsAhsuRKhphDlu.hl....VGcs-Vs-sLRTSsARDFsLu-ElshLpsllcluEcp-lslREKpLDll+WcWlE-ss.F.cYFslEplhAaLLpLtMIERWlpLDKc+GpphFRcIIsslK+ul	........................................................sp.YYhL.uhLs..t.-s..l.aohtphps.lh.thotpD.p.hslhhh.hD.tN.hthh..httcs......u...............hs.ppl.thht....t.t...........th.sah.pFl.ta.......................spp..............h...stLht.ahta.h.p..tspFlpsaapFp.slpslLsuhpuRhht.h...D...hu....l....su.ss.lhphLhpp.su..satLst.p.h..lppl....hp...tppsh..ht.....EcpLshhcW....phlE-hs.hhcYFsh-tlhuallpLthlpRhhphcp-+Gtp.F+pllpphcpt................	1	17	30	35
+10795	PF10963	DUF2765		Protein of unknown function (DUF2765)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	25.50	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.52	0.72	-4.03	23	119	2009-01-15 18:05:59	2008-07-29 13:28:37	3	1	113	0	21	93	0	81.90	40	88.01	CHANGED	IsLslsG..sDhpFssTsssYNcalNshspssKVsPA.+NaLhpsVcsEpK-sLccLl....psPGu..shplsutlhcEasPclpIsVKc	..................IsLslsG..s-lsF.pPs.suYNpalN-hshsNKVuPA.+sYLhRhVs.s.EsK-ALpcll....chPGs..uhQlsupVs-.YuPcl-IpVKp...........	0	4	11	14
+10796	PF10964	DUF2766		Protein of unknown function (DUF2766)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	21.20	21.20	21.30	86.00	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.66	0.72	-4.09	3	372	2009-01-15 18:05:59	2008-07-29 13:29:13	3	1	371	0	20	76	0	78.70	90	95.56	CHANGED	MScPLNsDQELVSDLVACQLVIKQILDVIDVIAPsEVRDKMSSQLKNIDFoTHPAAADPVTRRAIEKAIALIEMKF...TPp	MSQPLNADQELVSDVVACQLVIKQILDVLDVIAPVEVREKMSSQLKNIDFTsHPAAADPVTMRAIQKAIALIELKF...TPQ...	0	1	6	12
+10797	PF10965	DUF2767		Protein of unknown function (DUF2767)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	20.70	20.70	20.80	21.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.27	0.72	-4.13	4	459	2009-01-15 18:05:59	2008-07-29 13:29:51	3	1	445	0	22	84	1	64.50	87	98.89	CHANGED	MGNcsK--tLYQEMCRVVGKVVLEMRDLGQEPKHIVIAGVLRTuLANp+IpRStLphQAMEpVI+uLst	.........Msp.sK.-D-LYpEMCRVVGKVVLEMRDLGQEPKHIVIAGVL.RTALANKRIQRSELE...KQAMETVINALVK......	0	1	1	13
+10798	PF10966	DUF2768		Protein of unknown function (DUF2768)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillus spp.	20.00	20.00	22.20	22.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.73	0.72	-3.83	11	157	2009-01-15 18:05:59	2008-07-29 13:30:25	3	1	157	0	28	87	0	57.20	58	86.96	CHANGED	KMWhulGuMGhMFluVssIYLSRaKlps+FL+hlsuhlAYhhMllSGlIlhhVVhSGP	KMWhALGAIGFMFhAVuhIhLSRaKlKNKaLKuIsALVAYsLM.IVSGIlIFlVVFSGP..........	1	9	19	22
+10799	PF10967	DUF2769		Protein of unknown function (DUF2769)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins have no known function.	20.70	20.70	23.30	21.20	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.90	0.72	-3.67	16	59	2009-01-15 18:05:59	2008-07-29 13:34:54	3	3	24	\N	52	56	1	55.10	30	45.26	CHANGED	Ch..CssCPSastp.....tsctlFChpGpSptphhpc..GChCsp.CsVhpphpLpst.YYCh	..........Ch..C...Csoas.p..........................t.ttlaCspG.p.S.p.sphppcp.sChCss.CsVapc..a..pLpps....YaC.........	0	12	31	43
+10800	PF10968	DUF2770		Protein of unknown function (DUF2770)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as yceO however currently no function is known.	25.00	25.00	34.60	34.40	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.54	0.72	-4.28	6	426	2009-01-15 18:05:59	2008-07-29 13:36:04	3	1	421	0	15	52	0	36.00	77	92.93	CHANGED	MRRLhshLlNNlREHhMLYlhLWhLLAllDllalaa	.MRRLLHYLINNIREHLMLYLFLWGLLAIMDLIYVFY	0	1	3	10
+10801	PF10969	DUF2771		Protein of unknown function (DUF2771)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	28.00	27.70	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.08	0.71	-4.96	13	173	2009-01-15 18:05:59	2008-07-29 13:37:06	3	1	173	0	40	114	0	161.60	33	94.94	CHANGED	KR.....llulLhAslslllsuusGhhsWhLsRcsuPppPEISAYSHG+hsRVGPYpYCslls.c-.......Cpsspsp..GELsVst+tPlQLSlPpsIucAPWpLLplY-DPssssssh....aR..PsophAVTIP.oVDP.....pRGRLsGltVQLlTlVhDc..sGE.pslPHAEWSlcss	............hlAhl.sllVlllus..ss..uts.h.Wh.h.s.....ts.p.s.P.ppPcIosh.S..cGchpcVsPa.aCsls.s.p............................C......p.s...s.....p.st......spLs.......Vstc.tslpLSVPctIucsPWpL.Lpl.Y.pDPussspsh.........ap..ss.s.phu.VTls.......olDP.......pRsRLssltVph.l..........sl.s..........h.Dc..sG-.pshs.spWSVph.h.............................................	0	8	28	37
+10802	PF10970	DUF2772		Protein of unknown function (DUF2772)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as spore germination protein GE however this cannot be confirmed.	25.20	25.20	26.00	66.70	24.10	23.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.61	0.71	-4.04	10	140	2009-01-15 18:05:59	2008-07-29 13:38:11	3	1	138	0	20	94	0	122.30	52	94.64	CHANGED	sShVpsh+lsSlGISSVlQlGDopcIsh+o+sLAVQRphslFassEG...ctcpFplFs.cPIPhPtsposVps.shhHEsPsIcVpul+lhGlSuSSllpIGSTstVpu-SRlKHIRQLhs.....Psup	...lSlVQNVsIlSLGIuuVFQVGDuNQhELKSRALAVHRElPsYl+sEG...+hDAFcIFTDEaITIP+.R.T.....TD....V+l.NIlNE.CPFIEVNNVclRTlLNSusFQIGNVDYVFsNSRIhQIRQaIT..P...up......	0	4	12	14
+10803	PF10971	DUF2773		Protein of unknown function (DUF2773)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	40.00	40.00	24.40	17.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.69	0.72	-4.01	3	466	2009-01-15 18:05:59	2008-07-29 13:38:37	3	2	290	0	3	167	0	76.90	66	18.48	CHANGED	AL+NAHTPsuLLTTLTEPcaRSLAMNNPQLAADVKTAWLKEDPSLLLFVEQPDLSLLRDLVKTGATRKIRSEARH+LEEKQ	...........ALpNtHTPsulLss.h-Pp.h.lAhNNPphssDVhpAhLKcDP.LhLhlspP-LsLlRpLshsGtTRtIRppAh++L-Eh..	0	2	2	2
+10804	PF10972	DUF2803		Protein of unknown function (DUF2803)	Pollington J, Finn RD	anon	Pfam-B_1049 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	33.30	25.00	19.10	22.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.32	0.70	-4.83	51	345	2009-01-15 18:05:59	2008-07-29 13:47:24	3	2	277	0	85	277	98	147.80	25	71.11	CHANGED	hhtllsLlhlhhus......sAhA..................pphacVEVllFcpss......tpssEpWs.tps..hpsspshslhs..............................................................................................................................................................................ttt.hhLspsphpLsshtpcLpppssapsLlHhuWpQshh.scssu..........sl+lhuGcphsppa.............................................................................................................................................................hpl-Gslplalp+.....YLal-ssLplpp	...............................................................h....l.llhh..hhu.......suhA..................tt.aplElllFcpss............t.ssEpWs.tt...ht.pt...h...........................................................................................................................................................................................................hhs.pt.tL.......ss.hppLpppssapsLhHhAWpQs.t....ppu..........s.htl.uGpchttpa.......................................................................................................................................................................tl-Gplplhht+.....alhh-s.h.lp..........................................................................................	0	20	38	65
+10805	PF10973	DUF2799		Protein of unknown function (DUF2799)	Pollington J, Finn RD	anon	Pfam-B_1111 (release 23.0)	Family	Some members in this family of proteins are annotated as yfiL which has no known function.	25.00	25.00	31.90	31.10	23.20	19.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.42	0.72	-3.96	46	616	2009-01-15 18:05:59	2008-07-29 13:48:22	3	4	513	0	80	303	17	85.20	45	64.46	CHANGED	ssWtphGhpDGhpGpstps.sphtctssp.sht..sshttYppGYpcGttpYCs.s.uYplGhp........................................GptYhGlCs.s.....pFtppYppGpppa	.........DWYslGhcDAloGss.h..+.sscuau-s......p..ADpuhYhcGYtEG.pcchCpsDhsYthGLSG+sa...usCsssE.pAsph+csWQ+GtcE.p...........	0	14	32	52
+10806	PF10974	DUF2804		Protein of unknown function (DUF2804)	Pollington J, Finn RD	anon	Pfam-B_1045 (release 23.0)	Family	This is a family of proteins with unknown function.	25.00	25.00	25.30	26.60	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.95	0.70	-5.59	56	302	2009-01-15 18:05:59	2008-07-29 13:50:15	3	3	259	0	114	274	21	317.20	26	94.31	CHANGED	GpspaGthpu.spslshtchshhp.hcpshssht+hh+hKpapahslhssc..ahlulAluDlpYlusuFsYlaDhcssp..................hhppshlpPh.............shthphsspshpu..ps...papptphplph..p......................t...psthclp..............hsspslps-lplp..sststslslssPsuhs.G..a.saTpKpsulslpG.pl..plsscs................hs...hs.................puhAshDaotGah++cT..sWpWAohsuhhpt..........G..plGlNL.uuGhs-..TussENslWlsGchahL.sslpFcas+......ps.h.......t.........sW+lpS.....p.cscl...-LpFpPhspRp-+hNLhlltSsF+QhhGpFsGpl.hsss...GpplplcslhGhsEDHaA+	.............................h.s.hpt.spplshpch.hhp.hppslpu.......+hh+hKcapahslhssc..ahlulsluDlsYluhuhsYlhDh.pss.p.........................hh.ppshlpP...h......................ththphsps....shpu..ps.........ph.pp.tphplph...p...................................................p..puthplp.................hpst.slphchplp....ssstpsl...slssPhuhss....apYTpKps.slsspG..pl...phsspp.......................................hs....hs......tpuhAshDaupGhhphcT..tWpWu.uhsuhsp.....................G...tlGlNL.usGhs-....os..tsENsla.lsG...c..hphL.ssVpFchsp........................ts.h...............p................sWplpo.....t.sspl...-LpFpPhhpRp.pc..hNlhl...ltSsh+QhhGpFsGpl.thss...GpplplcshhGhsEcphA+..............	0	52	83	103
+10807	PF10975	DUF2802		Protein of unknown function (DUF2802)	Pollington J, Finn RD	anon	Pfam-B_1126 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.50	25.50	25.50	25.50	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.14	0.72	-4.22	44	303	2009-01-15 18:05:59	2008-07-29 13:52:17	3	1	299	0	84	222	66	70.00	42	48.15	CHANGED	lshGpcltclcpplp.plpp+lpcl.......p.ppDPpsthYscAsKhVphGAsl-ELhppCsLs+AEAELlhpL+pp	.....................................luhGp+lpEhpchlp.pLs-+l.pcL...........E.ppDs.suphYo+AsKhVpLG.AslsELhpcCcLs+AEAELhhpLpp....	0	22	43	66
+10808	PF10976	DUF2790		Protein of unknown function (DUF2790)	Pollington J, Finn RD	anon	Pfam-B_1206 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Pseudomonadaceae.	20.70	20.70	21.20	32.40	19.30	18.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.86	0.72	-4.19	48	247	2009-01-15 18:05:59	2008-07-29 13:56:06	3	1	62	0	76	187	5	82.00	36	89.77	CHANGED	hhlsshussAhApssssps.......................s.lppYcYGMpLDlA+Vluhos.ss..ssC.pVVPupMsYcDSpGch+tlpYpthGs.uCpp	..........................h.hlhshu.hAhAtpstptstt.....................stlcpYpYGMpLDlA+Vluho...sss..ssC.tVVPupMsY-DSpGph+slpYpshGs.uCs......	1	5	19	46
+10809	PF10977	DUF2797		Protein of unknown function (DUF2797)	Pollington J, Finn RD	anon	Pfam-B_1162 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	25.50	25.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.62	0.70	-4.73	54	434	2009-09-11 12:03:15	2008-07-29 13:57:29	3	2	422	0	141	419	288	227.10	37	82.58	CHANGED	G+plslpasGtI..pClsCG+cTKKSasQGaC.........asChpcLA.....pCDtCIM+PE...tCHactGTC.R-PpWucptChpsHhVYLA..NoSulKVGITRpoQ..lPTRWIDQGAspAlsIhcVssRhhuGllEstLpcp..luDKTNW...RpMLKups-.slDLhspcspLhphlspplppl.......................h.thst.......ht...p..thhplsaPV.paPpKlpShNhDKsPplp....GsLhGIKGQYLIhDsG....VlNlR+asGYpls	.............................................................GpplplpahGtI..hCspCG.c+TcKSau.QG.aC..................asCh.p.c.lA......pCDhCI.h+PE.....pCHact..GTC.R-spaucphChp...sHhVYLA....NoSslKVGITR..pop..lPTRWlDQGAsQAlPIhcVsoRhhuGhlEstLtpp..luD+TsW...RphLKGc.sp...slDLhthpppLhtt.h..sp.tl..tpl............................ttphu..........slp..l..pt...t.hplpYPV...pa...PpKl..p.Sh.N.l-..KsPhlp....GhLhGIKGQYLlh.DsG.......VINlRKasuYpl............................................................................	0	34	85	122
+10810	PF10978	DUF2785		Protein of unknown function (DUF2785)	Pollington J, Finn RD	anon	Pfam-B_1219 (release 23.0)	Family	Some members in this family are annotated as hypothetical membrane spanning proteins however this cannot be confirmed. The family has no known function.	25.00	25.00	25.20	25.10	21.60	24.50	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.76	0.71	-4.82	29	640	2009-01-15 18:05:59	2008-07-29 14:24:14	3	3	450	0	63	382	3	163.20	34	63.61	CHANGED	LhhcIspttsD.ulFpRSFos...LllAhllptcpp.....h.hLosp......phpplhpphlpYhthEpDhRGalppcGWAHuhAHsuDhLspLsppsph.spschhhl..lpslh.phlpp.sthahssE--RLupslhshlpps.lspcplhthlpph.....tshsshpt..t...s.hhthhNhppFLpsLhlp	............................Lh.pl...p.tpt.ushpRoFss...LlhuhlLpscpp.....h.hLopcphpslhsQhlpYlshE+Dh+Gas.p.phGWsHuhAHuADhLsEllppsph.sppphcEl..hssLt.phh.+h.hohhaps.sED.RLspslhphl.ps.lpp-plhshl+sl......phs..cp......p.hhh.htNh+shLpplahp............................	0	24	37	46
+10811	PF10979	DUF2786		Protein of unknown function (DUF2786)	Pollington J, Finn RD	anon	Pfam-B_1231 (release 23.0)	Family	This family of proteins has no known function.	22.20	22.20	22.30	22.20	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.99	0.72	-4.24	127	678	2009-01-15 18:05:59	2008-07-29 14:24:43	3	4	601	0	146	563	51	41.60	35	15.60	CHANGED	pKhLp+ItKLLthup.u..ss.pEAtsAhppApcLMtcaslcts	....pKhLp+Ip+LLthAp.u......ssttEAtsAhppApcLMtcaulst..........	0	43	88	127
+10812	PF10980	DUF2787		Protein of unknown function (DUF2787)	Pollington J, Finn RD	anon	Pfam-B_1249 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.70	19.70	20.70	21.70	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.85	0.71	-4.19	38	284	2009-09-11 12:53:47	2008-07-29 14:26:16	3	1	121	3	38	170	13	107.90	36	89.71	CHANGED	sppLtplLsphls......t.pt.ssuptlslNFRD.sYSA-pGGaHPVEIplp+.....psspWplsYITDFuYhG.shasELp+-LDFcFpst.sapthtG.hhslp...psp-LaplWppNFlsY.hshssac.lplos	............s...hpthLtthlp......p.ph.tpuctllhNhRD.sY.tcptGhHPVEltlpp.....pps.W.l.alssFuY.s..s.hspL-hpL.Fchtpt.haps.tGhhs.ltts.-st-LaplWpssFhta.lshpsap-lplT.............	0	12	15	27
+10813	PF10981	DUF2788		Protein of unknown function (DUF2788)	Pollington J, Finn RD	anon	Pfam-B_1255 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	39.30	39.10	22.70	18.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.23	0.72	-4.17	33	319	2009-01-15 18:05:59	2008-07-29 14:26:59	3	1	319	0	80	181	25	51.90	46	72.55	CHANGED	lhlsslhhaMuFIIaDLuK+SpAG+FGphllFhsLulGshGFlhKsllphhh	.....hlsulhhFlGhhIhDlhKpupss+FGphIlaLVLhLGshGFlsKslIphhh...	1	16	42	63
+10814	PF10982	DUF2789		Protein of unknown function (DUF2789)	Pollington J, Finn RD	anon	Pfam-B_1269 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.40	20.40	21.50	69.20	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.49	0.72	-3.96	60	290	2009-01-15 18:05:59	2008-07-29 14:30:47	3	2	263	1	93	240	24	74.30	46	91.22	CHANGED	M-psppshssLFpQLGLsssppuIcpFIspHp..LssslpLt-AsFWosuQtsFL+EplpcDA-WuEllDpLsstL	.....M-psppshspLFpQLGLsusctuIcpFIspHp..LsschpLt-AsFWosuQusFL+EplpcDA.-WutllDpLshtL.	0	19	43	70
+10815	PF10983	DUF2793		Protein of unknown function (DUF2793)	Pollington J, Finn RD	anon	Pfam-B_1370 (release 23.0)	Family	This is a bacterial family of proteins with unknown function.	21.20	21.20	21.30	26.60	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.98	0.72	-4.18	50	230	2009-01-15 18:05:59	2008-07-29 14:32:52	3	6	199	0	76	196	45	87.10	41	24.90	CHANGED	HNEALphL...DuLVQLuVtutshssPPusPupGspalluuu.A.oG..A.WuGps.GplAhapsGu..WtFlsPpsGWtsaltsc....uthhl..ac..GusWt	.......................HNEALphL...DulVpLuVpuhshssPPuoPA-GDRYIVuus.A.oG....A.WuGps.GplAta.s..Gu.....WhFlsPts..GWhuaVssE..............utlhl..ac..GusW.............	0	19	52	62
+10816	PF10984	DUF2794		Protein of unknown function (DUF2794)	Pollington J, Finn RD	anon	Pfam-B_1384 (release 23.0)	Family	This is a bacterial family of proteins with unknown function.	21.70	21.70	23.70	42.40	19.70	16.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.81	0.72	-4.12	33	238	2009-01-15 18:05:59	2008-07-29 14:34:32	3	1	235	0	81	190	1084	84.10	62	68.45	CHANGED	VtFcRpELspILsLYGRMVAuGEWRDYAIDhh+DtAlFSlF....RRuuEhPLYRIEKcPcLup+QGtYuVlutsG.pILKRGp-LtpVL	..sFcRpELstILslYGRMVAsGEWRDYAIDaL+D+AVFSlF....RRuuEhPLYRIEKsPKLtpKQGtYuVlussG.hILKRGH-LppVL.................	1	21	51	61
+10817	PF10985	DUF2805		Protein of unknown function (DUF2805)	Pollington J, Finn RD	anon	Pfam-B_001474 (release 23.0)	Family	This is a bacterial family of proteins with unknown function.	20.80	20.80	20.80	55.90	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.45	0.72	-4.03	58	227	2009-01-15 18:05:59	2008-07-29 14:35:38	3	1	217	0	75	214	1538	70.80	51	81.03	CHANGED	lsRIIEMAWEDRTPFEAIctpFGLsEppVIpLMRppLKsuSF+hWRKRV.oGRpTKHtth+s....ths...RhhsssQ..h	....sRIIEMAWEDRTPFEAIctpaGLsEs..pVIplMRppLKsuSF+hWRKRV.oGRpTKHtphRs......pht.....Rhhs.pQ................	0	28	57	68
+10818	PF10986	DUF2796		Protein of unknown function (DUF2796)	Pollington J, Finn RD	anon	Pfam-B_1354 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.50	25.50	25.80	29.10	24.30	25.40	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.00	0.71	-4.27	46	343	2009-01-15 18:05:59	2008-07-29 14:37:18	3	2	245	0	71	281	191	133.20	31	85.86	CHANGED	tsAH.HGtuclslAh-G.ssL.lplpuPuhslVGFEHAspocp-+ttlspAhspL.ppstpLFslssuAsCplppsplctshhtt.t.t...................+-+csHD....................+pp........................................pHu-hpupYpapCssssp...Lpplshs.hFppFPuscclpVphlsssuQpuscLosssspl	..........................tAH.HG.splsls.-G...ppL.hchpuPuhslVGFEHsspsstpcttlttAht.L.tps.tlFsls.tAtCphtp..lptshhsc.ptpc.t.c.....................+-+.c.tHD.............Hptc...................ccptpccttt.........................................pHu-hpspYphpCtt.t....Lptlpht.hFphFPshpplpsphls.ptQtuhplt.tps..................................	0	19	39	58
+10819	PF10987	DUF2806		Protein of unknown function (DUF2806)	Pollington J, Finn RD	anon	Pfam-B_001505 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.50	24.50	25.10	24.80	24.40	21.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.22	0.70	-4.85	32	239	2009-01-15 18:05:59	2008-07-29 14:37:38	3	1	199	0	53	155	23	210.80	36	73.28	CHANGED	tpRutpRtptpttppQpNlEsIhthAhsh...s.s-ssucs..hDsDWltpFhphAccIpsppMQpLWu+ILus.ElppPGoaSh+oLpsL+phTp+EAphhp+ssuhusphss-tp.cll.uhh.t.s.hphhpc.sspslsluphGlsauslLpL.-lGllptsE.....hEouplshsptlphphpspshpLps+pss.........lhhsYY+hTssGsELsp........Llss.........cssppYhctLts	.......................................h.pRAhpRtpppptp+QpNlEpIhthAtsp......scs-..ssu-s...DpDWlh+FF-hApcIpNspMQcLWAplLtp.ElsNPGshSh+sLchL.psMT.KEApllp+ssuhusphGu.-pph+ll.Ghh.t.....................uhhshsc+hsspsl.slupatLsYuSLLhLh-lGLlpssE......hEoG.cl..phcssl.hls.Y.pGpsh...p.....Lpspscs.........lplhYY+FTssGsE.Lsp........LlGs.........KsstpYa-tl..s...............................................	0	10	23	39
+10820	PF10988	DUF2807		Protein of unknown function (DUF2807)	Pollington J, Finn RD	anon	Pfam-B_001516 (release 23.0)	Family	This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In PDB:3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two.  It seems likely that this family belongs to the superfamily of trimeric autotransporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens [1] [2].  In the case of Parabacteroides distasonis, which is a cmoponent of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).	21.90	21.40	21.90	21.50	21.80	21.30	hmmbuild  --amino -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.03	0.71	-4.75	118	860	2012-10-03 02:33:51	2008-07-29 14:38:36	3	13	349	33	304	1003	203	162.60	17	72.10	CHANGED	sFsplp.lssshslhlp.p...u.spp.plplpuscsl.hsplpspl..c...sspLpIphc......cshsssp..............h.......hlplshss.Lptlshsuu.uplpsps......................lpspphplph............sGuGslplp.lpspplpsphsGuuslp.ls....................Gpspphpl.pls......GuGplcupsLp.sppsplplsGuGshplt.sspplcupls..GuGsltht..GsP	......................................................................................................................................................aptlt.ht.s.sh.pl.hh..p....u....st...pl...l....p..s...t.p..p.h..hp.l....p.hth...p......sstLh.lthp.........................pthp..t..................h........lhl......t...h...p...l.ptlp.h....s.u...s..uslp..hps...............................................................l.p.s..s.p..h.p.lph................................sGu......usl...p.h...p...l..p.s.s...p.l.php.h..s.G..u.uslp..lp.......................................G.p..s.p.phph..phs..........Gsu...pl..ps...t.p..lt....sppsp.h.ph.pusuphph.....s...p...t..p..l...p..hp...ht....usupl.h.s...........................................................................	0	98	229	290
+10821	PF10989	DUF2808		Protein of unknown function (DUF2808)	Pollington J, Finn RD	anon	Pfam-B_001529 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	22.20	22.20	22.30	23.00	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.66	0.71	-4.58	57	175	2009-01-15 18:05:59	2008-07-29 14:42:16	3	6	79	0	83	185	160	141.50	22	69.84	CHANGED	uhh.F.......s.ps.pplphhpspsttp..ptspahhhlhspcttpultplslsh...Pctacs..thpspplplpthp.s.........tpplP...stsphsp...s....spslplh.spPlssG.sslslshpslh.N..PptsGhYpFsspuhssGss..PhstalGohplsl	.................................................F....sps.phlphhts.stht..tsphYhhhhhspstspsltplslsh...spthcs....hphptlpspsh..t....................spsls...tpsphsp...c....spslslhhspPlssG.sslslslpslp.N...PphsGhYhFsspshssGps..shshalGshhlph............	0	16	57	79
+10822	PF10990	DUF2809		Protein of unknown function (DUF2809)	Pollington J, Finn RD	anon	Pfam-B_001533 (release 23.0)	Family	Some members in this family of proteins are annotated as yjgA however currently no function for the protein is known.	23.50	23.50	24.70	24.30	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.96	0.72	-3.58	49	416	2009-01-15 18:05:59	2008-07-29 14:43:19	3	4	395	0	103	363	9	94.20	33	68.37	CHANGED	GLhs+p........salpsahGDlLhshhlahhlthlhst............shhhluhhsllhuhhlEhhQlapsshl.sl+ssplutllLGssFsWhDlluYslGhh	..................................h.s+c........shlpsYlGDsLaslhl.ahhhthlhsph...................pstpluhhuLhFshhlEhuQLapsshl.slRss...slutllLGp..sFsWtDlluYslGs........	0	38	73	87
+10823	PF10991	DUF2815		Protein of unknown function (DUF2815)	Pollington J, Finn RD	anon	Pfam-B_002212 (release 23.0)	Family	This is a phage related family of proteins with unknown function.	21.70	21.70	22.70	22.30	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.13	0.71	-4.74	20	443	2009-01-15 18:05:59	2008-07-29 14:50:00	3	2	386	0	55	299	47	172.00	42	92.86	CHANGED	TKVlTsp.VRLSYs.plaEPcuh.sGp.....csKYSloll.......IPKuDspTlpuIcpAIcsAhcEGh.uKh...GsKhs..sslKhPLRD.GDh-ps.D-..tYss......saFlNAsS+p...+Ptll.....D+sspP...............l...h-psEVYSGCYuRsSIsFYAasssGNKGIusGLsNlQhl+DGEsLG.G+s.sAEDDF-slp..s-DD	.................................................................................................hKVlTGp..VRhSYs.plaEP+oh....pGp.....csKYSloll.......IP...Ko.D...sp...Tl.....p.......tIcp.AI-sAhc-..Gh..uKh......Gtpls.........usLK.h.PLRD.GDh......E...Rt.....-..........D....sY....ts......saFl..NAsSpp.....tP.tll.........Dpstp....................l....h-puclYSGsYsRsSI..s..h..au...a.N..o..NGN....KGIAsGLsNlQhlc..DGEsLG.Gts...uA-DDFsshsps.............................................	1	28	46	52
+10824	PF10992	DUF2816		Protein of unknown function (DUF2816)	Pollington J, Finn RD	anon	Pfam-B_002257 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	37.80	36.10	20.40	17.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.24	0.72	-4.38	12	70	2009-01-15 18:05:59	2008-07-29 14:53:14	3	1	3	0	60	73	1	63.00	55	23.64	CHANGED	EYEppppp..VPhp+hlTDYYsVEYpTEYIPQshhEK.lEYVPV-+ht-RV-YhsVERpsshp	.EYEEpppp..VP+E+hVTDYYAVEYQTEYlPQVh.EKhsEYVPV-RhpERVEYhsVERQVV+p......	0	60	60	60
+10825	PF10993	DUF2818		Protein of unknown function (DUF2818)	Pollington J, Finn RD	anon	Pfam-B_002280 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.20	25.20	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.20	0.72	-3.49	21	217	2009-01-15 18:05:59	2008-07-29 14:54:45	3	2	214	0	65	167	17	94.20	50	91.41	CHANGED	uulWlllLLALluANLPF.lspRlhslh.Phts......KshhhRLlELllhYhlVGhluhhLE.pphGpltsQGWEFYAIThsLFllhAFPGFVYRYLh++	.....................uhahlllLALlsANLPF.LspRLFull.Pl+p............Ksh...hh+lhELlshYhlVGsLuahLE.uRuGshasQGWpFYAlThsLalVFAFPGFlaRYhh+...................................	0	12	36	51
+10826	PF10994	DUF2817		Protein of unknown function (DUF2817)	Pollington J, Finn RD	anon	Pfam-B_002258 (release 23.0)	Family	This family of proteins has no known function.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.95	0.70	-5.36	32	141	2012-10-02 19:46:12	2008-07-29 14:55:34	3	3	121	0	72	727	173	323.40	32	89.81	CHANGED	F.up.oYspARp+FLsAAcssGs.....plpsashsh..GssGEsLuhDlAhhGsscApp.lLlloSGsHGlEGasGSusQlshLp-t..hspshssssul.LhlHAlNPaGFuahRRssEcNVDLNRNFl.......DaspshssNssYsclpshLlPsphsss...tt..tptslhphhtp+GhtshppAlssGQYpaPcGlaaGGptssWSstsL+pllpcah.sss..c+lsaIDlHTGLGshGtsphltts..pcssshp+spphaGst....ltshhss......sususshpGhhhpu...h..hphhsshp.hsulslEF.....GThsshpVhpALps-pWLah.................asc.sss.sptttl.+pplt-AFYPssspW+ptVltp	..................................................................................................................FupsYtpARp+FlsAA...pstut.....tlppa.pst.....G.....ssGEsLsh...Dl.Ah.......hGs.t.c..A..p+..lLllsS.GsHG...V...E..G......asGS.us..Q.....l.....s..h....Lpct..........hs...p...th....s........s...ss...ul....L.....hl.HAl..NPaGa..A..a..h..R..Rs.sEcNVDLNRNal........Da.s.p..shss....N...ssYtpl.p....shLhPsphsss...tt...stttl.tphhtpcG.suhppAlstGQYphPcGlFYGGptssWSptslcpllpcah..uss.......pclshIDlHTGLGshGtsph...lhts...psssthpcAt..p..h.aGss.............ltshhsu.......sususshpGhh...hps...h....hphh.s...ptp...hsslslEF.....GThss.......p...h..hpALp......s-pWLah.................a.sc.sts..sttttl.+ptlt-uFYs.ssssW+thll.........................................................................................	1	19	37	62
+10827	PF10995	DUF2819		Protein of unknown function (DUF2819)	Pollington J, Finn RD	anon	Pfam-B_002304 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.10	19.10	19.80	20.60	17.80	17.50	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.60	0.70	-5.67	20	554	2009-01-15 18:05:59	2008-07-29 14:56:58	3	1	539	0	47	328	5	305.80	70	59.78	CHANGED	hstp+tlu.GLAsLpp.spsphtapVsaWpscpGVsuspphhLptsssshhhsssppsstpst.......tsDEcRlhsspssl-tus.lPppWplh-sNssLhstups..spAATllFuhsppspl-tLApplapLRRppGstLKIlVREs.pssLRtsDEpLLLssGANLllstssPhSRhLThIEulQGQhFoR.lPpDlcsLLsh.spshth+GYlssssFsptVpshhssohhsp.lptsLVpLphlPGlpstpsLpLC+hRRsGDlsTsssspLYLFLpACRhNDl-sALspIFclPlsDlFsschlatsptpIpuElppl	.....................hpEYRSLF.GLASLRF.QGDQHLhDIAFWCNEKGVSARQQLslpQQsshWTLsppEEstIQP.........RSDEKRILSsVAVLEG.APPLSE.HWpLFsNNEsLFN-ART..AQAATlVFSLpQNsQIEPLARsIHTLR..RQRGS..AhKIlVREN.sASLRATDERLLLuCGANMVIPWNAPLSRCLThIES.VQGQpFSRYVPEDITTLLSM.TQPLKLRGFQp...WDsFCsAVpsMMsNsLLPAcGKGVLVALRPVPGIRVEQALTLCRPNRTGDIMTIGGNRLVLFLSFCRlNDLDTALNHIFPLPTGDIFS....NRMVWFEDcQISAELVQM......................................	1	5	11	29
+10828	PF10996	Beta-Casp		Beta-Casp domain	Mistry J, Wood V	anon	Manual	Domain	The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease.  The active site of this enzyme is located at the interface of these two domains [1].	20.30	20.30	20.50	20.80	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.83	0.71	-4.19	183	2338	2009-09-11 08:10:03	2008-07-30 13:33:19	3	44	1375	45	1245	2305	359	124.90	25	21.06	CHANGED	sQEllhh.......Lpchhp...ptt...........................hslalDSshuhcssplap..pa..chhs...p.h....pphht.tt...................................h.ph.phh..............cshcpscp.........l..p..t.t.P........s...lIluuoGM.hsuG....hlhcalcphhscs+Ns.llhsG...aQupGThG......+pl	.......................................................................................sQELlhh.......Lcphhpptt..............................................tphPlals..SshAtcssplap..pa..hp..hhs.ppht............cphhttpt........................................F...p..h..phl.........................................pshccppp...........l...tt.t...t..P............slllAusGM.h.puG...hshcah.c.ph....t....s....c.t+....Ns.llhsGYpspGThG+pl...................................	0	446	759	1049
+10829	PF10997	DUF2837		Protein of unknown function (DUF2837)	Pollington J, Finn RD	anon	Pfam-B_002349 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.40	20.40	21.80	21.10	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.45	0.70	-5.22	23	271	2009-01-15 18:05:59	2008-07-30 15:56:18	3	3	243	0	64	198	15	241.70	42	92.79	CHANGED	LThlIHlIsTLAYusRluGVRTt+lAsAhSLFNlhsLlSRsuNhhQuPLlupll-pulp.....................tpthusLtsphRh.llhuATlGTllGhlLlPTFlplFs+AIhth.cpsGSVP+Lhh+sh..ohpslcphcpplplPphp.lcpht...hppIP+cllllNhllouIYTlGVLuALYAGhLsPE.aRsTAutLSullNGhATILhslhlDPphSllTDcslcGcpspt-l+phshhlsho+llGTLLAQhlFlPuAhhIsalsc	.........................hThlIHsl-TluYulRLuGVRsp+IAlAlSlhsllhLlSRTuNhlQuPLlGtlVDpuhh......................sss....hsL.t.hRl.lLluAolGTlluhlLhPThh+lFuhsIpph.-ssGS.h.+hhhpsh..sh.p.tl.+hh+c..hl+hPphphlcplp...htsIPK+lhllNhhsTuIYTsG.VLSuLYAuhLh.P-.atosAsshSGlINGhATILLslhlDPplullTDcslpucpstpshpphhshLhhoRlhGT.LLAQllhlPuAhhIhalh.p.......................	0	24	47	53
+10830	PF10998	DUF2838		Protein of unknown function (DUF2838)	Pollington J, Finn RD	anon	Pfam-B_002381 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.20	25.20	28.20	28.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.55	0.72	-4.18	23	224	2009-01-15 18:05:59	2008-07-30 16:17:06	3	5	177	0	166	216	8	108.90	41	24.04	CHANGED	-Klsashulhslh....hsualhGthPphFhhaYTshhhhhMPlRaYoYpKpsaHYFLsD....hCYFlNhLsLlaI.....W.........laPpStpLFlssasluhGsLuhAlIsWRN.SLVhHSlDKlTS	.........-KlsahhGVh..slh......hsualhGthPphhhhaYol.hhhhhPlRa.as.Y++..p...saHYFLhD....................hCYalNh...Lhllhl......W...................haPp..SppLFhs.sasluhGsluhAl.lhWRN.SLVFHShDKlTS..................................	0	67	116	150
+10831	PF10999	DUF2839		Protein of unknown function (DUF2839)	Pollington J, Finn RD	anon	Pfam-B_002396 (release 23.0)	Family	This bacterial family of unknown function appear to be restricted to Cyanobacteria.	21.90	21.90	22.90	23.50	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.45	0.72	-3.94	37	107	2009-01-15 18:05:59	2008-07-30 16:21:36	3	2	77	0	38	103	267	65.90	40	86.86	CHANGED	MGEAKRRppp.GLsP+ptcppp.........hlshlPlocpQsp.hhtloh+usWlGIuhLslhWlslphl....GPssuWW	........MGEAKRRcph.sLss+ttpppp...........llsWlPlT+sQsc.hhphos+uuWlGIuhhshhWlslRhlGPshGWW...........	0	6	25	36
+10832	PF11000	DUF2840		Protein of unknown function (DUF2840)	Pollington J, Finn RD	anon	Pfam-B_002399 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	25.50	55.60	21.70	19.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.87	0.71	-4.66	34	168	2009-01-15 18:05:59	2008-07-30 16:25:56	3	1	109	0	89	180	13	146.90	51	87.02	CHANGED	LTcVELsWlEKRlEpWIRFG+sspEpllDRpRRlsuFtPuulFAFVRWAuNDaGTllSRlDIlRAlsPG-uaQTlPaV+PGG-lLL+lpGWPKVEcVLptIDAlEAlGIDPs-suPDaWRHVHNRLuAut.PRsYTt-RHtAWLtRRpl	................................LT+VpLsalEcRlEhalRFGcsucpphL.....DRpRRlssFtPGulFuhVRWtANDaGTlhSplDIlpAssPs-shQTlPhVcPGu-lLL+hcGWs+VcpVLptIDAIEAlGIsPs-VuPcaWRcltNRLuAs.s.psYTtERHtAWLtRRt.h......................	0	9	54	74
+10833	PF11001	DUF2841		Protein of unknown function (DUF2841)	Pollington J, Finn RD	anon	Pfam-B_002409 (release 23.0)	Family	This family of proteins with unknown function are all present in yeast.	23.50	23.50	24.30	30.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.87	0.71	-4.27	34	181	2009-09-11 16:39:17	2008-07-30 16:29:38	3	2	115	0	128	184	0	134.50	39	28.24	CHANGED	L.l.uss.ptlhpaYppsFcplQQhsC+tIAKAaIKllEP+KQspa.PYsttc..............poKPsWWP........ssVpH+EPDHLpK....................-RlpLLlaIlpphh.............hhsst+Lcpsstcstpt.hps.......t+hplLcEIacVtchE	.........pluspptlpsYYcpuFcshQQhsC+tIAKAaIKllEP+KQspa.PYsGuc..............poKPsWWP........psVhH+EPDHLpK...................s-RlcLLlHIlpplht............htl.ssc+Lc-sstsspp..p...hps.......c+h.lLcEIacVtc.....................................	1	19	56	103
+10834	PF11002	RDM		RFPL defining motif (RDM)	Mistry J, Bonnefont J	anon	Manual	Domain	The RDM domain is found on RFPL (Ret finger protein like) proteins.  In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex [1].  The RDM domain is thought to have emerged from a neofunctionalisation event.  It is found N terminal to the SPRY domain (Pfam:PF00622).	27.00	27.00	45.00	58.70	22.70	20.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.76	0.72	-4.29	23	72	2009-01-15 18:05:59	2008-07-30 16:34:42	3	3	20	4	24	79	0	42.00	65	13.91	CHANGED	VVSQKsDI+PshQLGpLVS+IKELEPpL+slLpMNPRM+KFQ	.VVSQKNDI+PshpLttLVS+IKELEPKL+plLpMNPRMRKFQ	0	6	6	7
+10835	PF11003	DUF2842		Protein of unknown function (DUF2842)	Pollington J, Finn RD	anon	Pfam-B_002411 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	30.20	30.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.13	0.72	-4.11	51	214	2009-01-15 18:05:59	2008-07-30 16:46:55	3	1	213	0	71	172	148	61.50	37	83.93	CHANGED	RKhluhllLllhlslYhllusslsshhh....p.shhlphlhYlllGllWl..LPhthlhphhsps-	...RKhlGsllLlshlhlYullAsslAsthlh....ssshWscLlaahlsGllWl..LPAhslltWMupP.....	0	17	44	53
+10836	PF11004	Kdo_hydroxy	DUF2843;	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_002426 (release 23.0)	Family	This is a family of 3-deoxy-D-manno-oct-2-ulosonic acid 3-hydroxylases, which catalyse the conversion of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) to D-glycero-D-talo-oct-2-ulosonic acid (Ko). It contains a potential iron-binding motif, HXDX(n)H (n>40). Hydroxylation activity is iron-dependent [1].	25.00	25.00	38.70	74.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.69	0.70	-5.41	13	168	2009-09-10 20:14:51	2008-07-30 16:52:13	3	2	164	0	50	124	11	277.40	55	93.40	CHANGED	cWsspss.sc.ttshhstLEpGKVLaFPcLsFsLsscEc.shLcPsh........sDsKpKNIShcPppGsl+G............ssscssstttlpullsRapppstsLlppLLPpYsssL+husTShR..PsphtsRssSWRKDDoRLHVDAFPSpPshGcRILRVFoNINPcstPRlWRlGEPFcshA+RFl.Ppsps.hP.hpuhL...........LptLtlTKph..........RSpYDHhMLpLHDtMKuDh-YQ+suPQ.pphsFPPGooWlsFSDQssHAsMSGQaMLEQTaaLPscAhtcsppSPLplLE+LsG+sL	..........t.Wstp...ss.tpphltuLEpGKVLaFP+LpFslpstEc.tLLDPsl........sDsKRKNIShcPptGsLpG............VsG.D...uss..utlRsLlsRatppAtsLVssLhPpYp...stL+sAsTSLR..PhpltsRpTSWRKDDSRLHVDAFPSRPNYGERILRVFTNlNPpGtPRlWRVGEPFpslA+RFL.Pplcs.sP.hsAWL...........hchL+lTKp...........RStYDHLMLpLHDtMKADL-YQKsuPQ.QshsFPPGSsWlCFSDQssHAsMuGQFMLEQTFaLPVpuMtpsppSPLtILE+LpG+sL...	0	9	26	37
+10837	PF11005	DUF2844		Protein of unknown function (DUF2844)	Pollington J, Finn RD	anon	Pfam-B_002433 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.20	21.20	21.90	40.70	20.30	16.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.63	0.71	-4.36	22	138	2009-01-15 18:05:59	2008-07-30 16:55:01	3	1	72	0	46	122	8	136.00	42	85.09	CHANGED	ApAsLGusssossusstshst.........................sttssssssuYol+phs.usGT..........slREYsssuGhVFAluWpGPshPDLssLLGoYhspahsuspt....tttsttshtVpssDlVlcouG+htsasG+AalPshlPuGVsss-l	........................ApAtLGGsshossAsststss.........................ssuussss..suYTl..RphshuuGT..........sl+EYsosuGsVFAluWpGPshPsLssLLGuYFPpYpuuspssc....tA+uspssstVssuslVlcoGG+MtuasGpAWLPsALPuGlossDI...	0	5	18	29
+10838	PF11006	DUF2845		Protein of unknown function (DUF2845)	Pollington J, Finn RD	anon	Pfam-B_002437 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.00	21.00	21.30	21.10	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-9.88	0.72	-4.15	40	206	2009-01-15 18:05:59	2008-07-30 17:05:35	3	2	125	0	59	181	22	83.40	32	79.66	CHANGED	sssuohRC.s.sslVohGDsth-VLtKCG-Ps...............p+s.hststst...............tthsttspsplE......cWsYshGP.sphhphlpFcsG+LscIcstt	............tssohRC.G.spLVstGDsth-Vl....t+CG...pPh...............s+cshshshsh...........................sthh...ptptsplE...........cWlY..GP....sshhhhLpFcsu+LhcIcst.t...........................	0	21	34	50
+10839	PF11007	CotJA		Spore coat associated protein JA (CotJA)	Pollington J, Finn RD	anon	PRODOM	Family	CotJA is part of the CotJ operon which contains CotJA and CotJC. The operon encodes spore coat proteins. Interaction of CotJA with CotJC is required for the assembly of both CotJA and CotJC into the spore coat [1].	25.00	25.00	26.10	25.90	22.80	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.52	0.72	-4.30	50	348	2009-11-09 12:01:11	2008-07-30 17:14:02	3	2	319	0	62	234	1	37.80	39	49.19	CHANGED	htlAhAYVPhQpap.s..hY.ssccALppGTlFP-Lst.........Pa	......p.sphYlsaQ..hs.s...a.sPc-ALp+.GTlaPsLhcPY...........	0	31	48	53
+10840	PF11008	DUF2846		Protein of unknown function (DUF2846)	Pollington J, Finn RD	anon	Pfam-B_002451 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as lipoproteins however this cannot be confirmed.	34.30	34.30	34.30	34.30	33.90	34.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.35	0.71	-10.54	0.71	-4.26	42	198	2009-01-15 18:05:59	2008-07-31 09:09:09	3	2	175	0	66	183	26	121.40	24	62.95	CHANGED	hloGC...............tstsssphpphtssp.....sp.utlYlY..R.suhhu......s..uhphsl.alsuphlGp.htsssahah-lssGp.aplus...cpthts................splslss-uGcsYalc.p.phss...............hsGsssl	.............................................hsGC.............hhstt.utp.htthpssst..........sp.AslYlY....Rssohhu......t....shthsl.a......lsu..ch....lGp.htsssahah-lssGp.aplus......ppthts................pplslsscuGpsYal+.p.p.sh...............hsG................................................	0	17	33	52
+10841	PF11009	DUF2847		Protein of unknown function (DUF2847)	Pollington J, Finn RD	anon	Pfam-B_002453 (release 23.0)	Family	Some members in this bacterial family of proteins with unknown function are annotated as YtxJ, a putative general stress protein. This cannot be confirmed.	23.10	23.10	23.10	55.60	22.50	23.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.18	0.72	-4.44	34	477	2009-09-11 05:12:55	2008-07-31 09:20:33	3	2	462	1	92	238	54	101.40	49	90.37	CHANGED	hp.LpohpphcplhcpotppssllFKHSTsCsISphuhppacphhstppp..lssYaLclhptRslSNpIAccasVpHcSPQllllcNGpslacsSHhsIstssLp	............KLooI-paEpllEc...Nch..hhlhKHSpTCPIStsAY...cpFppah.Ecc...hcuYYLhVQppR-lSshIAcchsVKHESPQshYhhsGchVWNssHtsIshsuL.s.....	0	34	68	84
+10842	PF11010	DUF2848		Protein of unknown function (DUF2848)	Pollington J, Finn RD	anon	Pfam-B_002463 (release 23.0)	Family	This bacterial family of proteins has no known function.	23.40	23.40	23.40	48.00	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.13	0.71	-4.83	37	154	2012-10-02 17:33:27	2008-07-31 09:27:34	3	2	143	0	64	156	32	191.50	44	83.57	CHANGED	AGWTGRDpsAlp+HIsELstLGVs.PussPlaYRVusshLopuspl.pV.GscoSGEsEhlllps...puplaluluSDHTDRclEsauVuhSKQhCsKPlupphWchs-Vts.HWDpLhLRua.ht.s..G.ppsLYQ-GoLuulhsPs-Llsths...sps.......hss...GsuMhsGTlssh.Gsl...psAspachELpDPstsRolcHuY	.............AGWsGRDtsAlpcHIcELt.t.LGVstPussPhaYRVusshLTQuspl.pVh.Gs.coSGEsEhl.Llps...sGchhVuluSDHTDRclEsauVshSKQhCsKPluppsWch.s-Vts.HWDplhLRoa.hs.s..G.-.csLYQ-GsLuulhsPp-Llpphs...tts.........thss.GsuMhsGTlus....h.Gul...csuspFchELpDPlhsRolcHsY.............................	0	14	28	48
+10843	PF11011	DUF2849		Protein of unknown function (DUF2849)	Pollington J, Finn RD	anon	Pfam-B_002560 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.50	22.50	24.30	33.10	22.20	17.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.99	0.72	-3.74	52	228	2009-01-15 18:05:59	2008-07-31 09:33:50	3	2	227	0	69	182	40	89.40	38	80.45	CHANGED	sKVlTANcLh-GsVVahsusspWoccls-AtlhscctpuphhLttu..ttpsspVVGsYls-sp.sssG.scPs+..hREphRspGPoshhctp	...KVlTANRLhDGpsVWLsAs...GpWscslspAhlhccs-ssssL.ttu...sspsstVVsshllDVc.pp.sG.....lhP..h+...lRE+IRt.pGPTlhs...s....	0	19	44	52
+10844	PF11012	DUF2850		Protein of unknown function (DUF2850)	Pollington J, Finn RD	anon	Pfam-B_002587 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Vibrionaceae.	21.00	21.00	21.30	21.20	20.70	18.30	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.48	0.72	-3.80	16	208	2009-01-15 18:05:59	2008-07-31 09:42:15	3	1	111	0	20	110	1	78.70	42	55.31	CHANGED	plYGpWlE.ssssYAs-phsLospGVhhNsRlluTsF-FDGphlpapsGsshhhYphssstps.pl+phpPuaY.shFhh	...clYGpWlE.ssssYts-plplsppGVhhNsRLloTpF-FDGstlphpsGsthaha-l.sptps..QhKpppss.s...hFh.........................	0	2	5	15
+10845	PF11013	DUF2851		Protein of unknown function (DUF2851)	Pollington J, Finn RD	anon	Pfam-B_002589 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	40.10	35.00	18.50	18.30	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.19	0.70	-5.73	27	226	2009-01-15 18:05:59	2008-07-31 09:46:59	3	2	217	0	67	232	79	357.70	37	86.43	CHANGED	MpEchLHalWpa+hFstps....LpTTpGc.lpllssGhhNpp.uGPDFFNA+lcIsup.hWsGNVEIHh+SSDWahHpH-pDsAYDsVILHVVaEpDs...pI.hRpsss.lPsLhLpthlspplhcpYppL.....htpcp..hlsCtspltslsshhhpsW....l-+LhhERLEpKsphlppLLppspscWEslhaphLs+sFGhplNucuF.plApslsFpslcK.......ppps.hplEALhaGpAGLLp.....tc...pD....pYhtpLpcEapaLp+KapL..pshssp.hpFhRlRPsNFPolRLAQLAsLap+p........psLFSplh.pspohp-ltplhp.lps.............SsYWcsHYsFs+topp+sKp...lucshl-lllINTllPlhasYupptupcphp.phhphlpplpsEpNs	.....................EphLHYlW+a+hFshps....LpTT....sGpslcllcsGhhNps.AGPDFFNA+l+I.ssp.lWsGNVEIHh+uSDWatHtHcpD.sYcsVILHVVh....pt..Ds.....pl.h.c......p.sGp.lPpl.Lp..l.....s.pplhppY..c..pL......htspp.......a.sC..hph..lss.lsphhhpsW....hstL.hERLEpKsptIpphLppspssWEpshFhhLA+sFGaslNu-AFcphAppl.Ph.pslpK.......p+s...sh..hQlEAlhhGpAGLLp..........pp.....pD.......sYhtpLp.cEapaLp+KapL...pshssphW+FhRLRPtNFPplRlAQLAtLatpp..........psLhSplh.pspslpplpplhp.sps................SsYWpsHYpFsp.St.ppp.Kp...lupstlslllINTllPhhasYupppspcth.p...pcshphLcplpsEpNp............................................	0	32	62	67
+10846	PF11014	DUF2852		Protein of unknown function (DUF2852)	Pollington J, Finn RD	anon	Pfam-B_002611 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.50	22.50	23.20	41.40	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.60	0.71	-4.13	35	197	2009-01-15 18:05:59	2008-07-31 09:51:09	3	1	178	0	58	151	19	110.90	47	81.94	CHANGED	shLDscG+sAWIAuMVLGFIhFWPlGLALLuYhIWS....+RMh..sp................uspscptp.t.t+hth.ht...............hpoSGNsAFDsY+t-TL+RLEEEQc.......pF-sFLcRLRcAKDKpEFDpFMs-Rpp	...................s.hlcsthpsAhIAhMVLGFhl.FWPl....GLAhLAYhlau......p+ht.thpc................spttcph.h.th...cptptp.s..................hsooGNsAFD-aRp-pLcRL-EEp+.......-F-sahpcLR+A+DK-EFDpFMs-Rc.s..............	1	11	31	41
+10847	PF11015	DUF2853		Protein of unknown function (DUF2853)	Pollington J, Finn RD	anon	Pfam-B_002619 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	31.80	31.70	21.30	19.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.36	0.72	-3.56	29	185	2009-01-15 18:05:59	2008-07-31 10:25:34	3	1	180	4	55	137	20	101.30	48	93.30	CHANGED	scYhsDlKccsut..sDh-llpKlstuhGPuIYNpDuuhVuuSDtpEL-pV+pNalhKKLGL.sD..sscLcsuIppVhEphGtopRsKaRsshYYhLsK+hsKpSs	...........s.cYhsDl+chsus..sD.sllpKlsptLG.AlhNpDuShVSuSDscELcpV+sNalhKKLGl.pD..sschDcuIscVsEshtss.RNKaRsshYYLlAKphGK.t.h..........	0	12	40	48
+10848	PF11016	DUF2854		Protein of unknown function (DUF2854)	Pollington J, Finn RD	anon	Pfam-B_002643 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	26.30	35.40	20.00	24.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.95	0.71	-4.67	23	116	2009-01-15 18:05:59	2008-07-31 10:33:03	3	2	100	0	54	115	127	144.00	44	69.27	CHANGED	lGhlAYhs........ssssLSLsshFYGlPlLLGGLALK......uuELpP.shptssssplhtlR-p.ATsp.splhpDVTRaRYGQcAHLEsSLctLtL..h....s--p.PpLhtlcEhptpusYuLhLcF-ssuVsl-cWp-K.p-+lu+FFu.GLc............Ac.lsp	..............................hGFsAYhs........ssusLslsshFYGlPlhLhGlALK......suEL+PlP..psots-hhsLR-ppATsp.splRpDVTRaRYGpcsHL-cuLcpLtL.s.....sccphPhLptlcEp.s.h................-.G.pYsLlLcF-us.tlsLppWpc..+..QpKhspFFGPGlpAclt........	0	12	38	50
+10849	PF11017	DUF2855		Protein of unknown function (DUF2855)	Pollington J, Finn RD	anon	Pfam-B_002665 (release 23.0)	Family	This family of proteins has no known function.	27.00	27.00	27.70	27.10	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.78	0.70	-5.28	35	108	2009-01-15 18:05:59	2008-07-31 10:38:43	3	2	98	0	56	115	238	310.10	33	86.50	CHANGED	FAlTANNlTYAshG-th.......sYWpFFPs..........ss...................uaGhlPVWGFAcVlpSpssslssGERlYGYaPhAoc...LslpPscVsssuFhDsusHRpsLsPlYNpYtRssuDstaps..sp-shphLlpPLFhTSaLlsDaLt-ps.......................a.aGA.......ppllloSASSKTAhGLAasLpt....pssuhcllGLTSssNhs.........FVculGsYDpVloYDclssLss........sssslhVDhAGsspllssLHp+hu-pLt....hsshVGsTHhcp.....ts.ssslPusp...sphFFAPsphp+Rhc-WGsssapp+hspuWpsFh..ppu......psalplpchpG.cAhppsYpchlsGclsP	.................FulTANNlTYAhhG-..t..h.......tYWpFFPs..........pp...................saGhlPlWGaApVltSppssltsGpRlaGYaPhuoa...Lhl....ps.sclsttuFhDs...usHRtsLsslYNpYtp..sss....-s..ha..ps..pp-shphLhRPLFhTSahlsDalt-ps............................h.auA.......pplllsSASSKTAhuhAahLp....................tptshcllGLTSssNhs.........FscuLGhYDpVlsY..-plsslss...........ss.slhVDhuGsssl....hspL+p+huc..plt........hss.hlG...hoc.pph...........................ts.stshsusp.......sphFFAPsphpcRhp-hGsst.htp+hstuWppFh.tts......tsalplpphpG.puhppsatplhsGpssP............................	0	16	35	47
+10850	PF11018	Cuticle_3		Pupal cuticle protein C1	Mistry J, Coggill P	anon	PRODOM_PD021041	Family	Insect cuticles are composite structures whose mechanical properties are optimised for biological function.  The major components are the chitin filament system and the cuticular proteins, and the cuticle's properties are determined largely by the interactions between these two sets of molecules. The proteins can be ordered by species.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.70	0.71	-4.12	14	170	2009-01-15 18:05:59	2008-07-31 10:41:37	3	7	37	0	121	192	0	118.90	26	69.21	CHANGED	sssAVuuoppsllRSas..usVSpYSKuVDTPaSSV+KsDoRloNsshp.uhutshh........................................aAAPshs...........huAPshsphAaAAPs.hhttts.......................tPsht..ths.huAPs.........spssYAAsAshhtt.h..................................stslsY.....SPAssV...SHhoas.GhGspYua	............................................................................t.t.t..sshS..ph..p..h...h..........................................................................................................hhh.sAPsht...............hsAPs..ht...t...s.a.u.sPs.hh...tt..........s....................uPsht....p.h..httPs..............h.st.s.....................................u..............................................................................................	0	31	42	102
+10851	PF11019	DUF2608		Protein of unknown function (DUF2608)	Mistry J, Coggill P	anon	PRODOM_PD862984	Family	This family is conserved in Bacteria. The function is not known.	22.10	22.10	22.10	27.30	21.60	22.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.52	0.70	-5.39	27	271	2009-09-11 09:18:18	2008-07-31 10:42:32	3	3	120	0	52	180	6	238.10	23	89.29	CHANGED	hhpspohpcV.tchlppt......pssLllhDlDcoLl.psp.pslups.ahphphpcl......thhts.pcshcplh.chl....hl.phhphchl-sshsphlsp.lpppphslhulophs........shpthphcpLpp.hslsFssss.........h.pps.h...hh.sthspsshahcGIlhosshs+u....tsLphhLsphsthPcpIIalDsspcsltshtpthpp..tsItahGhpYsstpt......s.hsphsps.h.pptphlpschsthhhpth.............sp	...............h.pspshpcl..chltpt......pshLllhslDpsll.ps.........t.p.htppshhph.hppl..........h.s..ppshp.phh.tchl....hh.pptphchlEs..phsshlsp.hpppthslhulophs................shpthhhctLpp.hslsFspps...................pp..........stttptshahpGIlaous..hs+u....tsL.hhLpphshhPc.....pllalssppcsl.shpphhpp...hsIsahGhcYsshph.........h.hspltp.hhh.p..tchlps-hthh..p......t...........................................................	0	12	17	27
+10852	PF11020	DUF2610		Domain of unknown function (DUF2610)	Mistry J, Coggill P	anon	PRODOM_PD199303	Domain	This family is conserved in Proteobacteria. One member is annotated as being elongation factor P but this could not be confirmed. This domain is related to the Ribbon-helix-helix superfamily so may be a DNA-binding protein.	20.70	20.70	20.90	21.40	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.63	0.72	-4.20	9	66	2012-10-02 18:44:02	2008-07-31 10:43:35	3	2	66	0	20	44	4	81.70	67	73.33	CHANGED	hKKF....hlsC-FGGQpuPFs.lYIGpP+s-sHPlpaQssWLScERGGsIPpcVh-SLp+LacLAccNslsFt-LCVYALs............sApps	...............YKcF....EFDCDFuGQRAKFK.FYIGTPQEGHHPLQFQAKWLSDERGGTIPD-VMcAISQ.LNDLAKKNGVPLsDL....CVYALGsAQE.s...............	0	5	9	10
+10853	PF11021	DUF2613		Protein of unknown function (DUF2613)	Mistry J, Coggill P	anon	PRODOM_PD383784	Family	This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	21.70	21.70	23.50	23.30	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.60	0.72	-4.26	8	144	2009-01-15 18:05:59	2008-07-31 10:44:20	3	1	135	0	33	86	0	57.40	51	94.35	CHANGED	Ms........RhlsPAlASAVlGlsLGusAlhGlThhsppsopPsh.p.ussuDsulLspVEYGuR	..................M.RhluPAsASsVVGllLGuuAlFGlTLhsppDspPsl..s.uscssSS.VL.s..cVEYGsR.	0	5	20	29
+10854	PF11022	DUF2611		Protein of unknown function (DUF2611)	Mistry J, Coggill P	anon	PRODOM_PD055124	Family	This family is conserved in the Dikarya of Fungi. The function is not known.	20.40	20.40	26.30	25.80	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.52	0.72	-3.89	20	135	2009-01-15 18:05:59	2008-07-31 10:45:16	3	3	114	0	102	127	0	71.80	35	85.81	CHANGED	MGssYpIhG+pVsSHhLAluTLGolhu.slshsstGss.....ps....ssPsIsASSc........DEEKFIppaLtch.............ppcp	..MsshYpIhG+pVssHhLAhuTLGshhu..sshh.ussGsp.....................ptt......ssPPIsASSs.........................DEE...c...FI...pcFLcphctt.......pp...................	1	27	58	90
+10855	PF11023	DUF2614		Protein of unknown function (DUF2614)	Mistry J, Coggill P	anon	PRODOM_PD355753	Family	This is a family of proteins conserved in the Bacillaceae family. Some members are annotated as being protein YgzB. The function is not known.	19.90	19.90	20.00	20.20	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.66	0.71	-4.29	9	167	2009-09-14 14:03:03	2008-07-31 10:46:40	3	2	166	0	33	113	7	109.80	67	95.57	CHANGED	thKYSsKINKIRTFALSLVFlGhllMYlGlFF+sp.llMslFMlLGhLslIASTsVYFWIGhLST+AV.VlCPsCtK.TKhLGRVDhCMHCcpPLThD+sLEGKEFDEpYNp.....K	.............................u..KYSsKINKIRTFALSLlFlGhhlhY...l...G....l...FF...+...pshllMThFMhlG.hLulIASTVVYFWIGML.STKs....VQll.......CPSC-KsTKMLGRV..D.tCMHCNpPLTLD+sLEGKEFDEKYNKK.shp............	1	10	23	27
+10856	PF11024	DGF-1_4		Dispersed gene family protein 1 of Trypanosoma cruzi region 4	Mistry J, Coggill P	anon	Pfam-B_187 (release 23.0)	Domain	This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known. Other domains on this protein include DGF-1_N, DGF-1_2, and DGF-1_5. This domain is just downstream from the C-terminus, but not the C-terminus of proteins, also annotated as being DGF-1, that constitute family DGF-1_C.	20.90	20.90	23.60	23.10	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.89	0.72	-3.59	20	257	2009-01-15 18:05:59	2008-07-31 10:47:44	3	4	2	0	34	257	0	73.20	79	3.14	CHANGED	VDGCNRTPuMP.LSHTATLTETRShTPT......W....TPuh..STs+YSPTp.....YusTETLQVTETVALsPTRTPTA..SVSSTLWWSD	......VDGCNRTPuhP..LSHTAT..LTETRS.......T..P..T......W........TPSh.....SssHYSPTp.....YGPTETL......QVTETVALsPTRTPTA..SVSSTLWWSD......	0	0	0	34
+10857	PF11025	GP40		Glycoprotein GP40 of Cryptosporidium	Mistry J, Coggill P	anon	Pfam-B_197 (release 23.0)	Domain	This family is highly conserved in Cryptosporidium spp.  Many members are annotated as being a 60 kDa glycoprotein.	19.70	19.70	19.70	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.91	0.71	-4.68	11	884	2009-01-15 18:05:59	2008-07-31 10:48:02	3	1	25	0	1	890	0	141.60	80	54.38	CHANGED	EoTPKEECGTSFVMWFGEGTPVATLKCGuYTIVYAP.KDpTDPAPRYISGEVpoVTFEK..SDNTVKIKVsGpEFSTLSosSSSPTENsG.Sus.QspSRSRRSLoEEsuETsATVDLFAFTLpGGKRIEVAVPssc-suKRsKYSLVADDKsFYTGuNSGsosGlY+L	....EsTPKEECGTSFVMWFGEGTPsATLKCGsYTIVYAP.KDpTDPAPRYISGEVpoVTF-K..p-sTVpIKVsG.-FSTLSssSSSPTENsG..Sus...QspSRSRRSLo.EE....su..Es.ATVDLFAFTL.cGGKRIEVAVPssE-soKRscYSLVAsDKs.FYTGuNSGsosGlY+L....................	1	1	1	1
+10858	PF11026	DUF2721		Protein of unknown function (DUF2721)	Mistry J, Coggill P	anon	Pfam-B_520 (release 23.0)	Family	This family is conserved in bacteria. The function is not known.	28.30	28.30	28.60	28.50	26.80	28.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.53	0.71	-4.51	95	398	2009-01-15 18:05:59	2008-07-31 10:48:42	3	1	349	0	183	381	997	124.60	29	85.49	CHANGED	shssPshLlsuIuhLLhshosRhspl...ssphRpLp....sp..hcs.pps.th......ptpl....ppLc+.RhpLIppshhhushohllsslshhhlFl...........shshhsshlFshuhlhLhhuLlhhLhElpluspuLclph	.................hssPuhLhsAluhlLhuhoNRhhplsshlRpLp.............sp....hpp....stsshh..............ttp.lpsL++Rhpll+th.hhushShhlsslshhhlal............shphhsshlFshullhLlhoLhh.lhElploscuLclp........	0	49	119	161
+10859	PF11027	DUF2615		Protein of unknown function (DUF2615)	Mistry J, Coggill P	anon	PRODOM_PD288703	Family	This small. approximately 100 residue, family is conserved from worms to humans. It is cysteine-rich with a characteristic FDxCEC sequence motif. The function is not known.	20.80	20.80	21.20	34.70	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.84	0.72	-4.09	13	97	2009-01-15 18:05:59	2008-07-31 10:55:39	3	2	82	0	60	106	0	96.60	47	97.95	CHANGED	MuDs......FDsCECIaSHEtAMRRLlsLLRQSQuYCTDoEC.pDlPu.P..ptsusus...shhhlhhsWhllAhsLYlhRPs.....ohRssp......sssKPpsspsssuss...PPsPsls	......Mu-s..FDPCEClhSHEtAMRRLIslLR.QSQuaCTDoEChp-.lsG.P.......uu..sss.........shhhlh..hsWhllAhhLallRPs.....shRssp.........hss.KPssspssps...........PPsPs..s............................	1	23	28	42
+10860	PF11028	DUF2723		Protein of unknown function (DUF2723)	Mistry J, Coggill P	anon	Pfam-B_590 (release 23.0)	Family	This family is conserved in bacteria.  The function is not known.	24.20	24.20	24.30	24.90	23.80	24.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.09	0.71	-4.79	45	364	2012-10-03 03:08:05	2008-07-31 10:55:57	3	5	295	0	152	370	354	175.40	39	18.99	CHANGED	DsGEaIusuhpLtVuHPPGAPLahhlGph.Fohhs...huplAhtVNhhSuluSAholhhhaaslshLltc.h..............tphstsphhshhuuullGALAauFSDoFWFsAVEuEVYAhuuhh.sAllhalhLpWccph.ps.............css+WLlllualhGLSh.GlH...hhsLLslPAluhlaaa+ca.tploh+s	.....................................DsuEaIssuhcL.pVuHPPGAPhFhLl.up.......l..F.o.h.F....s.....pss....plAh...hV.N.hhSuLhSAsslhFLFaolo+Ls+c.hh.................t.pths.hsphlhlhuuGllGALsaoFSD.oFWFsAVE..uE.V.YAhuuhF.sAllhWL....hL+.....W.-c.tssps................cusRWllLIAalsGLSl.GVH...hlsL....L.s...lP...AIshlaa.a+ch..p.p...t......................	1	64	106	129
+10861	PF11029	DAZAP2		DAZ associated protein 2 (DAZAP2)	Pollington J, Finn RD	anon	PRODOM	Family	DAZ associated protein 2 has a highly conserved sequence throughout evolution including a conserved polyproline region and several SH2/SH3 binding sites. It occurs as a single copy gene with a four-exon organisation and is located on chromosome 12. It encodes a ubiquitously expressed protein and binds to DAZ and DAZL1 through DAZ repeats [1,2].	25.00	25.00	33.60	31.60	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.06	0.71	-3.71	9	94	2009-01-15 18:05:59	2008-07-31 11:08:40	3	3	68	0	56	93	0	128.90	44	53.94	CHANGED	YssAPPu...YpphYpsuashPPsA..ths.hsAsa....Pss.hhhP..stshslushuppsPMtaYPhG..........sVYPsGu..........TVhVpGG.aDAGARFGsGsu.s.oIPPPPPGpsPNAAQlAAMQGtNVlhTQRKsNaFhGGSsGGYTIW	...................................................................................................................PPs....Ypth..Ypss...as.h...ssss....thsthsush....Pu..ss.ha..hPh...spshsl....u..sh.up.s.....h.P..h...u.YY.PlG..................s....hY..PP...Gu..................olhVpuu..a.DAGARF.ss.u.us.sssIPPPPPGCsPNAAQLAsMQGtsVlloQ+KssFFhGGosGGYThW.....................	0	16	20	36
+10862	PF11030	Nucleocapsid-N		Nucleocapsid protein N   	Pollington J, Finn RD	anon	PRODOM	Family	This is the N protein of the nucleocapsid. The nucleocapsid functions to protect the RNA against nuclease degradation and to promote it's reverse transcription [1]. The NC protein promotes viral RNA dimerisation and encapsidation and initiates reverse transcription by activating the annealing of the primer tRNA to the initiation site [2].	19.60	19.60	22.00	26.80	17.30	16.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.20	0.71	-4.44	2	41	2009-01-15 18:05:59	2008-07-31 11:15:03	3	1	5	0	0	33	0	133.30	84	100.00	CHANGED	MNSMLNPNAhPhQPpPQVVAhPhQYP.GFpPtFRRpRNPGFRPMFpRR..NNuNQNRuRQsR.RlQNppRG..hNhpsstQRuNRRQ.NQ.S.slPFEQQLLMMANETAhuATaPPEhQslAPTKLVKIAKRAAMQIVSGHATVElSsGspDos++lATFTIKVshN	...MLNPNuhPFQPQPQVVAMPIQYPMGFQPRFRRRRNPGFRPMFQRR..NNSNQNRSRQsRsRIQNQRRG..lNoSRTQQRANRRQNNQQSLSLPFEQQLLMMANETALSATFPPELQSLAPTKLVKIAKRAAhQIVSGHATVElSsGppDos++lATFhIKVshN	2	0	0	0
+10863	PF11031	Phage_holin_T		Bacteriophage T holin	Pollington J, Finn RD	anon	PRODOM	Family	Bacteriophage effects host lysis with T holin along with an endolysin. T disrupts the membrane allowing sequential events which lead to the attack of the peptidoglycan. T has an usual periplasmic domain which transduces environmental information for the real-time control of lysis timing [1].	19.80	19.80	19.90	22.40	18.40	19.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.30	0.70	-5.19	5	43	2009-01-15 18:05:59	2008-07-31 11:27:23	3	1	38	0	0	44	0	200.40	49	98.42	CHANGED	scVStuh+u-lLhslLDRLFKDssoGclLlpRVhlllLLFlMAllWYsssElFuaYKco+YETYsEIlQsERsc+FEsAApEQLQIVHVSScADFSuVaSFRPKNLNYFVDlIAYEGKLPoTlsEKsLGGaPVNKTS-EYpVHLsG+HYsScp-F...AYLPo+ccohE...lsYMYSCPYFNLDNIYAGoIoMaW++KPc.Is-.....E+LssICNQAARILGRA+	.........................s-lLFGlLDRLFKDsuTGKVLhSRVhllllLFlMullWY+s-plhshYKpopapsYschlpp-+ss+F-ssAhEQLQIVHlSStADFSAVaSFRP+NlNYFVDllAYEG+LPsolscKsLGGaPlDKTSpEYpsHLsGppa.Sspch......saLPo+..c.s.c...hsYMYSCPaFNLDNlYAGoluhaWhc.c.Pp.lsp.......-+LpslCuQAuRhLGRs+...	1	0	0	0
+10864	PF11032	ApoM		Apolipoprotein M (ApoM)	Pollington J, Finn RD	anon	PRODOM	Family	ApoM is a 25 kDa plasma protein associated with high-density lipoproteins (HDLs). ApoM is important in the formation of pre-ss-HDL and also in increasing cholesterol efflux from macrophage foam cells [1]. Lipoproteins consist of lipids solubilized by apolipoproteins. ApoM lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide [2].	20.60	20.60	21.00	20.70	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.31	0.71	-4.72	4	77	2012-10-03 08:47:39	2008-07-31 11:35:15	3	2	40	5	37	102	0	164.30	37	93.66	CHANGED	MhHplWsaLLYLYulhhsSlu.CPu.s.LsssGlctppFPp.aLGpWYFlAuAA.PspctLATFcPlDNlhFshttuuss.pL.LRAsIRhKsGhCVPRcWhYhLscGsT-LRhEG+Pch+TpLFS...usCPcsIILKET..spuYpRhLLYuRpPpsstcsVp-FpshsuChsao.hL.hPppQ-ACploS	.......................................h..hh.hh.lhhts....C.....s.lss.shstpph...hLGpWaFlAuAu...spppLtphpshD..shhhshssuoss.pLplptslRhcpGhClscpW.h..Y.pLs..p..s..o.ss..L.p..h...E..G+.sc...h+spLas...ssCPss.IhLp.Eo.........spsapR....hL.LYsRsscss-cslEEFcuhspCLshc..thh.hP.ppthC.h...........................	1	1	3	18
+10865	PF11033	ComJ		Competence protein J (ComJ)	Pollington J, Finn RD	anon	PRODOM	Family	ComJ is a competence specific protein [1].	25.00	25.00	25.90	25.40	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.37	0.71	-4.49	7	123	2009-01-15 18:05:59	2008-07-31 11:38:10	3	1	121	0	16	69	0	128.10	58	96.00	CHANGED	M.......ELoISYpQhhlhph-upPPslDWTDEshE+GYApuDsAV.FEAlpshpspltlpLssphphtuh.RplTVPFpVtp-slhIpSlhSp+lphsIPpGcYpLsh.osP...spcs-Lat.pY.l.Fpsh	.............MELTISYSQLMLMNYDGEQPYVDWTDEDFERGYAcADGoV.IFEA.LSDY..T..CEVKVTsGKH..I.E..K.EEV.lRTloVPFTV.c.N.E.sIslTSILSN.K.FpIPIP.NGEYTVVLQAsPLEEPTDDELYKIQYEFFFES.K.......................	0	4	10	12
+10866	PF11034	DUF2823		Protein of unknown function (DUF2823)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins are possible glucose repressible proteins however this cannot be confirmed. Currently, no function is known.	25.00	25.00	34.90	32.90	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.23	0.72	-3.85	11	69	2009-01-15 18:05:59	2008-07-31 11:43:39	3	3	46	0	56	63	0	67.40	55	89.33	CHANGED	METlK....NAuNYVuEoVQuAsusASKEANKpVAKDSsAuluTRssAAtDAlsDKt-EppHDAKA-sHKpu	..................M-olK....pAuNYVoEpVQuAousASKEANKpVAKDS...sA...ulGTRsoAAtDAluDKhcEppH-ucA-saKpt...........	0	18	32	49
+10867	PF11035	SnAPC_2_like		Small nuclear RNA activating complex subunit 2-like	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is SnAPC subunit 2-like. SnAPC allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element [1].	21.50	21.50	22.00	23.60	20.40	21.40	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.03	0.70	-4.96	3	65	2009-01-15 18:05:59	2008-07-31 11:57:22	3	2	32	0	36	49	0	234.00	43	98.19	CHANGED	MKPPQRRRAlPARYLGEVTGPAAWSAREKRQLLRLLQARQGQPEPDAAELARELRGRSEAEIpcFIQQLKGRVAREAIQKlHPGGhcGPRRpETQsPAPIEVWMDLAEKITGPhEEALTVAFSQVLTIAATEPVSLLHS+PuKPTQARGKPL.LLSAPGGQEDPAPEuSSPAPtAPu.........sscssGSsP+TPG.......PAPEAPSESLAGsSTEcDFAVDFEKIYKYLSSVSRGG+GPELSAAESAVVLDLLMALPEELS+LPCTALVEHMTcTYt+LTAPQssLAGGuLu.PGTEDuGAGS+GPEETsQASPQAoEsAtpSEP+SuWQAAGICPLNPFLVPLELLuQAsoPAR	.................................................................................................................................................................ltsalp.LKt.sspEslpp...th..t.Rpppsp..APIElWhDLAc+lTGshEEulssAFSQhLTIuAsEPloLhaS......hPs+s.spsps+.h..hp.s.t.ppp.ss..sts...s......................................................................u.ss.s...hp....ph..........VDFEKIYKYLSphu+sspuspLS..s.s..ESAVlLcLLMuLPEELshLPCssLhcHhhpsYhpL..hu..Pp.s....ust....s.s....sss...Essssssp.s....pps.....s....s.......st.s.................p.....hptht......hs.PLNPFhlPLphLtp.........................................	0	1	3	9
+10868	PF11036	YqgB		Virulence promoting factor	Pollington J, Finn RD	anon	PRODOM	Family	YqgB encodes adaptive factors that acts in synergy with vqfZ , enabling the bacteria to cope with the physical environment in vivo, facilitating colonisation of the host [1].	20.10	20.10	22.90	50.00	18.50	15.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.18	0.72	-4.45	2	382	2009-01-15 18:05:59	2008-07-31 13:08:21	3	1	379	0	6	24	0	43.00	84	96.41	CHANGED	MKKKPVAQhE+Q+.LLENPhsYGLLSphphAIVVNCFTLsph.	MKKKPVAQhERQHoLLENPCAYGLLSQFQAAIVVNCFTLNKII...	1	1	1	3
+10869	PF11037	Musclin		Insulin-resistance promoting peptide in skeletal muscle	Pollington J, Finn RD	anon	PRODOM	Family	Musclin is a muscle derived secretory peptide which induces insulin resistance in vitro. It encodes a 130 amino acid sequence including a NH(2) terminal 30 amino acid signal sequence. Musclin expression level is tightly regulated by nutritional changes [1,2].	20.70	20.70	22.40	21.60	18.20	17.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.61	0.71	-4.53	3	49	2009-09-11 15:35:46	2008-07-31 13:09:12	3	1	36	0	27	34	1	123.70	65	94.62	CHANGED	MLDWRLASVHFILAlTLMLWuSGKVLSsDlAocsF-.StslulpuPPTAoEEKSAT-LAAKLLLLDELVSLENDVhETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKKRFGIPlDRIGRNRLuNSRG	...........MLDWRLsusHFI....LAlo.LhhWSSGKVlSs-ss.o.E.A...FD....SullclQS.sPTsp..EEKSATDLsAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHK.GKQRKsV-hPKRRFGlPhDRIGhNRLssoRG..........................	1	1	3	9
+10870	PF11038	DGF-1_5		Dispersed gene family protein 1 of Trypanosoma cruzi region 5	Mistry J, Coggill P	anon	Pfam-B_157 (release 23.0)	Domain	This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known.  Other domains on this protein include DGF-1_N, DGF-1_2, and DGF-1_4. This domain is just downstream from the C-terminus, but not the C-terminus of proteins, also annotated as being DGF-1, that constitute family DGF-1_C.	25.00	25.00	39.10	39.10	17.90	16.70	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.88	0.70	-5.19	3	286	2009-01-15 18:05:59	2008-07-31 13:12:31	3	5	2	0	52	286	0	248.30	89	11.79	CHANGED	AGGSLT.sDIRso.....GuAVPc+LhVALPPPFR..WARDPQLGTHLoF.shsSpuQPsGauGPWGE.MLRNATWVRNATNPSTVLELAVPVHRGYFIGADETIVIRCDAVAVaGGCKGVLLGuFTIsSNTPPAlASALSAITGVVAGAAAVAVVVTGGLGSILEMQALGVFARMSCASAQERASTVALPYFLSVFAALDPLWMVVGNALLAAVFGCVHYGVTAAFQRWRGVDAASAWAAMRFPSLTYVVAHAMHLGIFFGSVFALAMPGARVQHYVIGVVGVLYG	....AGGSLTQNDIRGG.....GSAVPThLMVALPPPFR..WARDPQLGTHLSF.VPVSTAQPpGFGGPWGA.MLpNATWV.RNATNPSTVLELAVPVHRGYFIAADETIVIRCDAsAV.GGCKGVLLGSFTIRSsTLPAAASALSAITGVVA.GAAAVAVVVTGGLGSlLEMQALGVFARMSCASAQERASTVALPYFLSVFAALDPLWMVVGNALLAAVFGCVHCGVTAAFQRWRGVDAASAWAAMRFPSLTYVVAHAMHLGIFFGSVLALAMPGARVQHRVIGVVGVLYG...............	0	0	0	52
+10871	PF11039	DUF2824		Protein of unknown function (DUF2824)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function. Some members in the family are annotated as the P22 head assembly protein gp14 however this cannot be confirmed.	25.00	25.00	25.00	25.20	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.87	0.71	-4.49	3	167	2009-01-15 18:05:59	2008-07-31 13:13:44	3	1	163	0	4	76	0	148.80	65	99.31	CHANGED	MITFpPTRNIDLIEMVGNHPDIIAGSNNGDGYDYKPECRYFEVNVHGQFGGIVYYNEIQPLTFDCHAMYLPEIRGFSKEIGLAFWRYILTNTTVQCVTSFAARKFRHGQMYCAMIGLKRVGTIKKYFKGVDDVTFYSATREELIDFLNHGR	........................MIpFpPTRNIDLIEhVGNHPDIIAGSNNGDGYDYKP-CRYFEVNVHGQFGGIVYYpEIQPL...TFDCHAMYLPEIRG.FSKEIGL.AFWRYILTNTTVQCVTSFAARKFRHGQMYCAMIGLKRVGTIKK.YF.K.G..VD...DVTFYSATREELIDFLNHGR......	0	1	1	1
+10872	PF11040	DGF-1_C		Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus 	Mistry J, Coggill P	anon	Pfam-B_30 (release 23.0)	Domain	This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known. This is the very C-terminal part of the protein.	25.00	25.00	49.90	48.00	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-9.84	0.72	-4.09	26	256	2009-01-15 18:05:59	2008-07-31 13:20:46	3	4	2	0	31	256	0	80.50	80	3.82	CHANGED	WYAEDRHWQELREPRRGGLEALLRDDEESDE-TQKPH-hTSSSYASGTTsASSYRPPAP.....................QPMAGDTRSDALSLhDRASSASspIs	.WYAEDRHWQELREPRRGGLEALLRDDEESD.EETQKPH.-.MTSSSYASGTTVAS.SYRPPAPP.....................QshAGDTRSDAhSLhDpuSoAut.l............	0	0	0	31
+10873	PF11041	DUF2612		Protein of unknown function (DUF2612)	Mistry J, Coggill P	anon	PRODOM_PD048079	Family	This is a phage protein family expressed from a range of Proteobacteria species. The function is not known.	22.90	22.90	23.00	23.70	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-4.72	18	287	2009-01-15 18:05:59	2008-07-31 13:21:32	3	2	240	0	38	254	0	165.80	26	78.34	CHANGED	shtshllhQYpspP+hhuhlpthtshh.sshhphlss.lsslaDlDsAsGhtLDllGchVG.luRhlps....t.aFuF..shtuhsa.......stu.ahs.hcstsssstLsD-sYRhLI+sKlhpNhhcsTlsslsshhp.lFuss...sallDshDMo..hsssVssphhoshhhtllpphsllP+PsGVplpa.ll	..........hhthlhspatspPph.shlphhsp.h..sstshhps.h.phaslDoA.GhtLDlhGphlG..hsRhls...s...t.ahua.....s...t..s.hsa..................spus..a...s.s.p.s..s.ss.......htLsD-tYRhll+sKhhtNhh.cuossslsthLchhassp...phhlh....Dst-Mo....hhlh.p....t..hssh...ph...thlpp....h.....lh..s+ssGV.h.....h..........................................	0	3	17	27
+10874	PF11042	DUF2750		Protein of unknown function (DUF2750)	Mistry J, Coggill P	anon	Pfam-B_609 (release 23.0)	Family	This family is conserved in Proteobacteria. The function is not known.	21.60	21.60	22.10	21.80	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.36	0.72	-4.01	71	710	2009-09-11 13:47:04	2008-07-31 13:22:01	3	2	507	0	130	400	30	105.20	33	68.29	CHANGED	RhphFl..pcltpppplWsLpcccG..alhhsos-t-s........hPlWsscchApt..asss-WpchpstsIsLscah-pWlssLpcDslhlul...stsp.pGhhlpPp-lsppLt	.........RhphFl..p-ltcpppVWuLpccpu....alhlsss-p-p.........hhPlWsp+ptApt..hss..-..-...Wt.-h.cshsIshshFhEtWLssLc-Dsht.Vu.lsh.sssh..GhllpspcLsp-L..................	0	27	54	99
+10875	PF11043	DUF2856		Protein of unknown function (DUF2856)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this viral family of proteins with unknown function are annotated as Abc2 however this cannot be confirmed.	25.00	25.00	71.00	70.90	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.19	0.72	-3.87	3	202	2009-01-15 18:05:59	2008-07-31 13:23:26	3	1	181	0	3	78	0	94.10	88	99.85	CHANGED	MPAPLYGADDPRRCSGNSVSEVLDKFRKNYDtIMSLPQETKAER-FR+sIWLAEKpEKERIpQTSIRPFRKATYTKFIE.IDPRLRNYRSRYGAISNN	................MPAPLYGADDPRRCSGNSVSEVLDKFRKNYDhIMSLPQETKEEKEFRHCIWLAEKEERERIYQTSIRPFRKATYT+FPE.IDPRLRNYRSRYGAISND	0	0	0	0
+10876	PF11044	TMEMspv1-c74-12		Plectrovirus spv1-c74 ORF 12 transmembrane protein	Mistry J, Coggill P	anon	PRODOM_PD019016	Family	This is a family of proteins expressed by Plectroviruses. The plectroviruses are single-stranded DNA viruses belonging to the Inoviridae. Except that it is a putative transmembrane protein the function is not known.	20.80	20.80	20.80	22.00	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.45	0.72	-4.41	4	35	2009-01-15 18:05:59	2008-07-31 13:24:13	3	1	6	0	0	33	0	48.60	76	87.95	CHANGED	MPTWLTTIFSVVIlLulFhahGL.IYQKIRQIRGKKK-KKEIccKEspc	....MPTWLTTIFSVVIlLGIFsWIGLSIYQKIKQIRGKKK-KKEIE+KEspK...	0	0	0	0
+10877	PF11045	YbjM		Putative inner membrane protein of Enterobacteriaceae	Mistry J, Coggill P	anon	PRODOM_PD079046	Family	This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.	25.00	25.00	31.30	30.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.78	0.71	-4.36	6	477	2009-01-15 18:05:59	2008-07-31 13:25:27	3	1	474	0	30	104	2	118.90	78	99.49	CHANGED	MtppphWhuhhsCFlLF.lVhL..thtspGuFc.uuG+sElGLLhFlLPGAVASahSpR+RlL+PLhGAllAAPlCLllh+LahsPsRSFWQELAWlhSAVFWCuLGALCaLFlpoLhpthRp+..pR	..........MKHKptWAuslCCFVLFIVVCL.Ls..hHM..KGAFR.AAGHPEIGLLFFILPGAVASFFSp....RREVLKPLFGAMLAAPCSMLIMRLFFSPTRSFWQELA.WLL.SAVFWCALGALCF.LFISSLFKsQHRKN.Q......	0	1	5	17
+10878	PF11046	HycA_repressor		Transcriptional repressor of hyc and hyp operons	Mistry J, Coggill P	anon	PRODOM_PD091544	Family	This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction [1].	25.00	25.00	91.40	91.30	21.50	19.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.85	0.71	-4.26	4	465	2009-01-15 18:05:59	2008-07-31 13:26:04	3	2	462	0	21	85	0	147.90	88	96.20	CHANGED	MTIWEISEKADYIApRHRpLQ-QWHhYCNSLVQGITLSKARLHHAMSCAPpc-LCFVLFtHFtIaVsLA-GFNSHTIpYaVEsK-Gp-+pLIAQAQLshDGhlDG+Vs.RDR-QVLEHYL-KIAsVYDsLYsAlEpDhPVcLSpLlhuc	..MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYYVE..TK...DGEDK...Q.R...IAQAQLSIDGMIDGKVNIRDREQVLEHYLEKIAGVYDSLYTAIENNVPV..NLSQLVKGQ........	0	1	3	12
+10879	PF11047	SopD		Salmonella outer protein D	Pollington J, Finn RD	anon	PRODOM	Family	SopD is a type III virulence effector protein whose structure consists of 38% alpha-helix and 26% beta-strand.	25.00	25.00	27.20	26.00	24.00	23.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.79	0.70	-5.47	2	272	2009-01-15 18:05:59	2008-07-31 13:26:32	3	6	136	0	9	152	0	274.40	60	89.82	CHANGED	MPVTLSFGN+pNYplNcSRLA+LhSsDKEcAlaMGsWD+hpDpFRscKKpcsLEVLaolIHGptRtp.uEhpVslpshpKIaAFppLpchAsPupQDhFsh+hDhsQTQhLh.lsspVIspsNl+clLNlS-sslhcsMpc-EcpLFLpIC.hhGtKhohaPELLpt.hspL+ctVstssplKstVYchMRsuEs.ch.hVEWpsoLTE-EKshLtClphGsFp.TTQFhKIGY.ElpGEVhFsMhHPslSYLLpsYpP...u-hh.TNoh.F.chLNpDYsDYpspKh.IDsILc+lYhoHppoLaIuccussRNhLl	..............MPVTLSFGN+p.NYplNcSRLA+L..hSuD.K.EcAlaMGsWD+hpDpFRscKKpcALEVLaolIH...Gp.GRtc.uEh-Vsl-shs..K....IaAFc+LpphAsP...up..QDhFsh+hD.ho..Q..T...QhLhhlsspVISpsN.l+..clLNlSDssVlcsMsc-EcpLFLpIC.hhGtKhoh+PELLQp.hspLRctVstsspIKstVYchMRPuEs.chshVEWpsoLTtDEcshLsClphGsF-.oTQFhKIGY.El.pGEVhFsMhHPsl.YLL+uYpP...s-Fp.oNoh.F..chLNpDYsDYpspKh.IDsILc+lYhoHppoLaIucsussRNhLl.....................................................................................	0	2	3	5
+10881	PF11049	KSHV_K1		Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus	Mistry J, Coggill P	anon	Pfam-B_38 (release 23.0)	Domain	This is a highly glycosylated cytoplasmic and membrane protein similar to the immunoglobulin receptor family that is expressed as an inducible early-lytic-cycle gene product in primary effusion lymphoma cell-lines. This domain would appear to be the cytoplasmic region of the protein [1].	20.90	20.90	21.30	43.00	20.40	16.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.59	0.72	-3.99	13	1340	2009-09-11 12:24:34	2008-07-31 13:28:52	3	4	3	0	0	1052	0	67.90	71	41.93	CHANGED	YTLTCPSsASLPISWYCNsTRLhRL.Tsp.TlTl.ss.lTCNFTCVsQSGHpHSIWIpWasQPVLQTLCAQPSNT	.YTLTC.SssSLPISWYCNsTRLhRLTpp.olTV...so.l.s.CNFTCVpQSGHRpSIWITWasQPVLQTLCAQPSNT................	0	0	0	0
+10882	PF11050	Viral_env_E26		Virus envelope protein E26	Pollington J, Finn RD	anon	PRODOM	Family	E26 is a multifunctional protein. One form of E26 associates with viral DNA or DNA binding proteins, while a second form associates with intracellular membranes [1].	25.00	25.00	69.30	69.20	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.53	0.71	-5.13	8	16	2009-01-15 18:05:59	2008-07-31 13:29:20	3	1	13	0	0	16	0	186.80	49	99.87	CHANGED	MEosp.....lsssaAs.K..tuAlss.....hV+TVVTTTssSspstsp......cs+IsQlIAQLp+TRLsFsKLopLQ+KRVRNMQ+LlRKKNplIAsLAApLpsppp........+...sKaFAVshsKNllhThSGSEpFVRpRVA-LCAh.GGEQVFCuRRADCARDRpRlAcALssSLGuGVlspusNKRFEIh-s-KlVSAKLIlQQVLHDGhcuDssAa	.........MEosp....h.sstaAs.K.pthAVss....ohs+TVsTTTssSshscp.....-ppp+IsplIupLppT+LsFsKlpplp+K+lRphQpLlRKKNpIIAsLstpLpstpc................hKaFuVshscNslhTh.GsEpFVRpRlA-LCsh.suE.VFCttRsDss+DRptlAphLssuhGutVlshtsN+RFEhlps-clsSuKhll.phLpDt.puDhsAa.....	0	0	0	0
+10883	PF11051	Mannosyl_trans3		Mannosyltransferase putative	Mistry J, Coggill P	anon	Pfam-B_379 (release 23.0)	Family	This family is conserved in fungi. Several members are annotated as being alpha-1,3-mannosyltransferase but this could not be confirmed.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.95	0.70	-5.05	117	725	2012-10-03 05:28:31	2008-07-31 13:29:41	3	19	160	0	543	759	22	250.80	23	44.84	CHANGED	u+GIVhsu.......Gs...th.hh.h.thl+hLRp.hG.....spLPlEllh.s..s-h..spchppplls............................................hls....spsllhsshhsp.hh...........................s..ap.......hKhlAllhSSFEcllhLDADslslps.P-p.hFp..scsappsG.hlhW...-hhppshsshhhplhs.....................h.....tt...t.......................th.hpph.sth.ptssESG.llls..Kp....pHhpsLLLuhaaN.hasss.......hha.hhs.G......D.....KEoFhhAshhh............................s..psYa.spp.ssslGhhst..........................................p.phs.usthuphD	............................................................................................................tcGIVhss.........us....phh.hsh..thl+hL.Rp.hG.....spLPlElhhhs..s.-h.......spphpptlhs................................................h.ls...........sp..s.l..hh..p......phhsp..hh....................................s.ap....h.KhhAll.hSoF-c.llhLDuDslshp....s.Ps.........h.lFp................sp.sap..ps.G.hlha........s.....hh..p..p...p..h....tshhhp.lhp.........................................................................................tth.tth...phptESG.llls..Kp....p..H.h..ts.Lllshahs..hht.p........h.h...h.hs.G.......DKEhFhhuhhhh............................s...psahhspp..s.ssh.Ghhpt.......................................................thpu.thhphs.................................................................................................................................................................	1	117	294	503
+10884	PF11052	Tr-sialidase_C		Trans-sialidase of Trypanosoma hydrophobic C-terminal	Mistry J, Coggill P	anon	Pfam-B_103 (release 23.0)	Motif	This is a highly conserved sequence motif that is the very C-terminus of a number of more diverse proteins from Trypanosoma cruzi. All members of the family are annotated putatively as being trans-sialidase but this appears to be a diverse group.	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.89	0.72	-7.06	0.72	-4.06	45	797	2009-01-15 18:05:59	2008-07-31 13:30:14	3	9	3	0	143	798	0	24.70	62	3.66	CHANGED	uuos+GsshL...LLLL..LLGLWG..hAAl	...uuTs+G..us..lL..PLLLL..L.L.GLWG.FAAL.....	0	0	0	143
+10885	PF11053	DNA_Packaging		Terminase DNA packaging enzyme	Pollington J, Finn RD	anon	PRODOM	Family	Phage T4 terminase functions in packaging concatemeric DNA. The T4 terminase is composed of a large subunit, gp17 ad a small subunit, gp16. The role of gp16 is not well characterised however it is known that it binds to double-stranded DNA but not single stranded DNA [1].	25.00	25.00	30.30	29.60	19.80	18.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.91	0.71	-4.61	7	72	2009-01-15 18:05:59	2008-07-31 13:33:08	3	1	69	15	0	59	837	144.80	36	88.29	CHANGED	MsD..L.DhspLhDlsu..lPG.lpuE-spV.YpPlVLp-VcSpPpsRshDL-cDYslVRcNhHFQpQMLMDhAKIhLEsAKNu-SPRahEVFusLMsQMTssNKElL+lHK-MK-IT.pphtp...uupsshpsplQNssl.....FhGSPs-Lh-.ElGD..p.	.................................................htt....G....s.p.....apP......l..lpSp....P...p.s...cssDlcpDYphsRpshH.hQpphhh-AuchhLEsA+so-uPRthEVFupLhpphssssccLlcLpKcMK-los-p..t.p..ts.ssspsshpNs.Tl.....FhG....Sss-Lhc.plts..........................	0	0	0	0
+10886	PF11054	Surface_antigen		Sporozoite TA4 surface antigen	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is a Eukaryotic family of surface antigens. One of the better characterised members of the family is the sporulated TA4 antigen. The TA4 gene encodes a single polypeptide of 25 kDa which contains a 17 and a 8 kD polypeptide [1].	25.00	25.00	63.50	63.40	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.83	0.70	-5.00	12	29	2009-01-15 18:05:59	2008-07-31 13:51:46	3	1	2	0	0	29	0	240.70	41	97.62	CHANGED	hshhsllpsSLLhlu.s..GputssttsspYTAshGtslpCLuElNuARcAAGLssFt-A.ossppLscPssp-h....psuopW+.clCcaLlP..ps-ssstusshpPFptGTYAFKsLTsspssCK-sV-YWKuAacNFoG.LPPocspuss..lYssQpNVSFVALYNPpusAoADCpVVTCTpssssss..........ussplpu-stpt.........spsGaAlICKThPuAF.s-sosPFTp-QWcKIVsSLTGS........sSsshPSlsshhIsshuhhuL	......................h.h.sllphSLLhl.s.....upptsptttsphTAs..tslcCLsEhNssRcAAGLssFtp.A.sssthLspsuspph.....psso.Wp.clCptlls..pscss.spssshs.F..GTaAatslTsspssCK-sV-YWKuAacsFsG.LPPohptsss..lYscppsVSFVALYNPpssss.AsCtllTCTpssss........................ussplpu.-sttt.........sppuhAllChT.PsAh.sssosPFTp-QWcKIlpSLoGS........sSsssPolsshhlsshuhhuL.....	0	0	0	0
+10887	PF11055	Gsf2		Glucose signalling factor 2	Pollington J, Finn RD	anon	PRODOM	Family	Gsf2 is localised to the ER and functions to promote the secretion of certain hexose transporters [1].	25.00	25.00	46.40	46.30	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.29	0.70	-5.94	9	45	2009-01-15 18:05:59	2008-07-31 14:01:25	3	1	44	0	29	42	0	367.10	46	95.97	CHANGED	hElYlRhNDDhE+DYsFQlcpscThcs.lhKIFs.......oh.hsLRPSlFacscPlGFpKSspPGYLTEsGsLlFcY-Ascpcahcpls..cchlh-plWPGQLILPhWchsphshasFlslhlsWLYTDLPDhISPTPGICLTNQLSRhhh.lAppash.clAppLht-lp.s.sulsAQhLFFlhHllKllhIhhhhYhGhhNPlphN.aphhsh+pph..................hKcpLhslGWhGARRAThD-Yp-hYhpYtIccaGGhlpAaRA..Glhcphts.GlpLusGEGFpTPL-c+hThsThpshcpct.....KFhLS.-YFspLtpshcp.l-cpsG..uchsspI+pFRRaGlhcss-clpclVphRKthsspcc..............p.KhE	.MEIYlRhNsDhE+DYsFQVss-cThps.lhKIFs............u..hsLRPSIFacpcPltFhKShpPGYLTEsGsLlFcY-Aspcc.lppls.csc.lh-plWPGQLllPcWchschshasashlhLsWLYTDLPDhISPTPGICLTNQlSRhh.h.lAcp.hshsclAs+LtpElp.s.sulsAQhlFFlhHlhKlslItLFLhhGlhNPISFNshphhs.l+s.s.......t.............s.hKppLpolGWhGA+RAThD-YpspYhsYhIcKhGGhVtAa+A..GhhcphtssGlpLssGEGFpTPL...-c+.aTtsTFpsl.cp-t.......KFlLS.EYFlcLppsL+c......l...-ch-G..-l....uchNtpI+cFRRaGlaEss-+ltplVphR+phscp.p.............pppt.................................	0	4	15	26
+10888	PF11056	UvsY		Recombination, repair and ssDNA binding protein UvsY	Pollington J, Finn RD	anon	PRODOM	Family	UvsY protein enhances the rate of single-stranded-DNA-dependant ATP hydrolysis by UvsX protein. The enhancement of ATP hydrolysis by UvsY protein is shown to result from the ability of UvsY protein to increase the affinity of UvsX protein for single-stranded DNA [1].	22.80	22.80	24.80	27.40	22.20	22.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.45	0.71	-4.01	9	67	2009-01-15 18:05:59	2008-07-31 14:03:14	3	1	65	0	0	59	954	129.50	31	92.29	CHANGED	phccDhhID........sopLppEuhc.PhLauKWLphaoshpp.hhclEhpt+pslK-Rh.aYoG+u-..sEVsh-h.....hcpS.ElKhslsuD-cllclssplpYhphlhcFhppuLctlpsRGFsIKshIEhR+hEuGt	........................hcpD.hID........sspLp.-uhp.shLasKahchasshpphhhplEtchKphhKp+hpYYsG+us..sphhh-p.....hppo.ElchhlsADc-ll+lssplpYhphllcFhcssLctIpsRuapIKNhI-h++FpsG...	0	0	0	0
+10889	PF11057	Cortexin		Cortexin of kidney	Pollington J, Finn RD	anon	PRODOM	Family	In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species [1]. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex [2].	25.00	25.00	47.50	47.30	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.90	0.72	-4.38	5	92	2009-01-15 18:05:59	2008-07-31 14:10:38	3	1	36	0	63	63	0	80.10	57	97.67	CHANGED	Msosasl.PSPss.............................................sSussluusSLoLEQKTuFAFVGlLhlFLGLLIVRCFRILLDPYSSMPoSSWsDclEGLEKGQFDYALs	........................Msus.sh.spsh...............................................ssssssssul....oLEQKTsFAFVhlLhlFLGlLIVRCFRILLDPYSSMPoSTWsDphEuLEKGQFDYALs......	0	3	8	22
+10890	PF11058	Ral		Antirestriction protein Ral 	Pollington J, Finn RD	anon	PRODOM	Family	Ral alleviates restriction and enhances modification by the E.Coli restriction and modification system [1].	25.00	25.00	84.80	84.70	21.70	16.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.53	0.72	-4.60	2	90	2009-01-15 18:05:59	2008-07-31 14:13:30	3	1	82	0	1	27	0	53.70	89	99.79	CHANGED	MTTTIDTNQWCupFh+CpGCKLpuECMVKPEEMh.VhEDGKhVDKWAIRTTtMIARELtK...KAh	...........................MVKPEEMFPVMEDGKYVDKWAIRTTAMIARELGKQNNKAA.....	0	0	0	0
+10891	PF11059	DUF2860		Protein of unknown function (DUF2860)	Pollington J, Finn RD	anon	Pfam-B_002667 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.30	21.30	21.30	22.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.60	0.70	-5.37	29	262	2012-10-03 17:14:37	2008-07-31 14:23:33	3	1	230	0	25	207	14	288.20	40	91.00	CHANGED	GFSGplolhsGhsuspSsh.....ss.psssphssh..ssuupocosslshPLGslpYTFupt.spQlFhGsscsDlhsGphthElGYcpphssssslshShlPslhp.sEsWpDPYhssssRppTDhsspuhRlphpplhs..usasl-hAaucp-lDpEpou.................ts.LcRsuphahhchsYphsL..spshhLpPulsYtppDADGcAhSaspaGsplohhhhhscHplslThuhupppYDu..sNPIFs+s.p--sphuhhhsYpYpshasacshuhsuhsGaspscSNIsFYDpsphllSlGlsYp	...............................................................................................GaSGsLSlssGhtcsKSNh.....sT..ssssh..losh...sus.sS-oshlsh.huplhYs.h.s.NsplFhts.sscslsG...htLGYc+ta.cthshohShlsSLh..pcsatsPYhhss.RppTDlst.GaRlu.hh..s..stFoh..sYsau..cpKlDc-p.u.................pupLpR...-upYaplchsYshuL.......Ls.ulsYs.pDAD...GcAp..SaopaG..aplGsph.h.F.u.p...s.hh.lT..suhuhpcY-s..scP...IFsKp.pDu..shhph.hthV...hpphhGapsl.hhu.hGlpcpsSs.I.s.FYDpp.pll.TGluYp..............	0	6	14	20
+10892	PF11060	DUF2861		Protein of unknown function (DUF2861)	Pollington J, Finn RD	anon	Pfam-B_002683 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.00	48.60	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.57	0.70	-5.04	43	183	2009-01-15 18:05:59	2008-07-31 14:27:32	3	1	112	0	17	107	0	251.20	41	89.45	CHANGED	WFcs.TPLppuaQtLlEschsphappLlcshppsP...lppph.pLltpul..pspCG+uLsspshsDhh.uVThh+phsQo.tt.ph+Luh-shTps.lscls.sp..ssplluu-.uhs...........ttpYs.scphsLhuPhuAGlYpLolsspc.t.......lllusssupphlc.o...Spc-apIchsAh.supsP....SluhapahDtNap.l...............aSpThcsD.Psuh.ssshPSptahlolSlIppcaQGsItlEQhQplohshD	...WFcp.TPLppuaQpLLpschpphappLlcshphp....lpspL.phlhpul..pssCG+uLs.sp.shPD.WlpuVT..lhRp.lQSssp.th+lul-stop...s....l..sclphoph.sspllus-suhs..........ts.Ys.scphsLhsPhuAGlYplslsstctt...a.tWllluss.upphlcWo...Sc..c...-.apI.pp..sshhsupCPhPphSlula.sahDsNYp.l...............WSpoh...cs.DhPs..s..L...ssslPSspahloVShIppRaQGsltlEQ.QhIohshD.................	0	3	6	13
+10893	PF11061	DUF2862		Protein of unknown function (DUF2862)	Pollington J, Finn RD	anon	Pfam-B_003005 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	26.50	33.20	23.50	21.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.90	0.72	-4.26	26	91	2009-01-15 18:05:59	2008-07-31 15:02:59	3	1	73	0	34	85	165	61.70	46	76.61	CHANGED	IGpKV+..l..s+l+DRlspcllctltppshGplpsaKhsDGpGlGllVcLssGppsWFFEDElp.	.IGpKV+..V..pRlRDRlsspllcpLsp..hGslpsFKhTDGp.GIGllVchs.D.ssssWFFEDElc...	0	5	22	32
+10894	PF11062	DUF2863		Protein of unknown function (DUF2863)	Pollington J, Finn RD	anon	Pfam-B_002981 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	26.60	26.30	24.10	23.00	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.10	0.70	-6.38	12	116	2009-01-15 18:05:59	2008-07-31 15:34:25	3	1	112	0	44	96	40	389.90	56	97.80	CHANGED	t+hRsppps+Lu.-ApcLlsLAhuLstSGSRlEDtaWEppLsttls+LL+suspssL-AALDHLaptsssAY-.LA-tsEohuESh.lppsGtcaDlLLlAAPlLAWoRYpIPoGsl.sshhpsLtspLQuHVLAsss+lALssaLaS.DQLPRoaspThpLspcLupAALsup.sl+lphpshPETushLuDsRYLlAulusPpGpPlFRWQEpsps............pR-tsLtpWppQutssLusLLPGCthElLLPDAYasusRpAD+psRPhSlRAuVsaLpssLshssspL+AVluuFsEc....plEEYRIGFTh+sps-VlYGlVWPLhGp-......................u-s-sssslppIpAlL+EsGVp-lhphsthFs.EYC-DCGAPLaPs.pGElVHAEhPE-.u.sss.ph	...............................................h...Rp+tupRLsPDA-+LVuLuLALhASG.SRlE.DpaWEs+LsshLuKll+NGsQosLDAALDHLtpscs-.AYssLA-hAETtSEShslE....+.-...G..p..YD........ALLlAsPlLAWTRY..hI..P..SGslKs-lspsLpsHL.QAH.VL.AssspVAlAPaLYSIDQLPR.pHs.......-TapLsp.........pLApA.ALusp.ss......KlshsDhPETuPILA.D....P.....RaLLAlVuAPt.GtPLFRWQE-pcs.........p+..hERspCLEQWssQusssLushL..PG.......CEFEs..LLPDAYasACR-ADcRlRPhTVRsAlpYLhsTlu.ssPpcLRAVlAGFGEc....RIDEYRVuFTtRGS.sDVIYGlVWPLYGREsGps............p.puEss.suPLEEIsuLL+EsGVoDlRRHuu+FEPEYCDDCGsPLYADPhGEIVHAEMPED.AssuQPHF......................................................................................................	0	6	22	32
+10896	PF11064	DUF2865		Protein of unknown function (DUF2865)	Pollimgtom J, Finn RD	anon	Pfam-B_002953 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.90	19.90	38.80	33.00	18.00	16.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.87	0.71	-4.22	28	141	2009-01-15 18:05:59	2008-07-31 15:47:56	3	1	83	0	72	148	4	114.00	35	34.84	CHANGED	GuspshCVRoCDGhaFPlsttsssush......ptCpuhCPuucsclah....sssshctAsuhsG.csYuchPsAFtYRpphs...ssCoCpsts.s....uhu.hshpscsohct.GDllsopsuh	......shpshCVRoCDGtYFPluhssssuc..h.t....ptCpuhCPuucsplYh....s........upshctAsuhsG.csYssLPsAFtYRpphs...ssCoCpsts.s.....u.u.hs.hppcs.s.h.ct.GDllsstptt.........................	0	12	29	41
+10897	PF11065	DUF2866		Protein of unknown function (DUF2866)	Pollington J, Finn RD	anon	Pfam-B_002950 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	29.80	32.10	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.43	0.72	-4.05	9	112	2009-09-11 09:26:37	2008-07-31 15:52:26	3	1	56	0	28	74	3	63.30	54	73.21	CHANGED	hslpuCRVSsPlppPWGtuhRlVEW.hctsuphpRRVVss-uTstElstsltpHV.GR+athsss	..slpuCRVS.shppPWGtshRlVEW.hchDuphtRRlVss-sTEAElstsltp.V.GR+Yhh......	0	2	4	14
+10898	PF11066	DUF2867		Protein of unknown function (DUF2867)	Pollington J, Finn RD	anon	Pfam-B_002931 (release 23.0)	Family	This bacterial family of proteins have no known function.	20.90	20.90	20.90	21.00	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.65	0.71	-4.48	57	1086	2009-09-11 16:38:42	2008-07-31 16:01:40	3	3	983	0	243	790	164	137.50	35	34.25	CHANGED	ltshhssscahDsasltls....s..ss.ph.htchhs....psPsWlstLhtlRstlVp.h.GLcs.....................shtsusp.........luhFslhspssp......ElllutcDpH.Lshclslthpstpt........lphoThV+h+Nhh.GRhYhhsltPhHt.lIV.shL	......................................hhhs.................................................................h..s..h..LWpsRuhhD+hl..Gtch............t+G.Rsptp..........hLpsGDs......................lDsW+Vl.hl-Pc.................p.L.L.hG.h..c.....ss...t......L.....G....R..L..s..h...s..lc..-cG..chcp..............lclp.....Aaa....HP.+Gh..GhhYWhhhhPsHh.aIF+GM..............	1	87	158	214
+10899	PF11067	DUF2868		Protein of unknown function (DUF2868)	Pollington J, Finn RD	anon	Pfam-B_002930 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as putative membrane proteins. However, this cannot be confirmed.	26.50	26.50	26.60	27.60	26.30	26.40	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.05	0.70	-5.29	35	236	2009-01-15 18:05:59	2008-07-31 16:14:17	3	3	228	0	62	233	20	301.60	30	66.01	CHANGED	phhhhht..p+htpsspss..hs.AL......hthhtptplt+WhlutlsHthWlshhhuuLhsLLlllsspcauFsWpTTL..LusssahpLspsLuh.ss...hlGhulPssphIpASchs.............sssssustttWusaLlusllsYGlLPRLlLhlhshhth+psttp..LslshPtYtpLppRhtssshphus.t-s-ssthspspsssshttts.....................................sslhsulElssp..............hs.shuttpsls-............sccthpplhtthsttsssplllsscsppsPDRGs.lshlspLsppssssphllLhsssu......................shssp+lppWpptlpphsls	...........................................................................tphh+stpss.phs.tL.......ht..hcp.hsRWhluthsHuLWLhsLlusLlslLhLlhsRpYsFsWEoTL..Lus..sshlplsphL.u.hlPu...hL..G..Fs...l..PDsphlhuoph...................ss.sstpuWushLlGsllsYGlLPRLLhhhhChhhh+puppt...LDLptPhYptLhcRhtsphtctss.p-ss..ssshspht.hsss................................................................................................................................................................................sthhlslEhc.p..............h.sthsptlhDts.....................hssRcpht..tL.ppLpph.P.....up..lll..us.csppsPDRGs.LthlscLuc..sAtust..lhhL.s.tu.....................ps..sp+ltpW+ptLpphth......................................................................................................................................................	0	17	34	54
+10900	PF11068	YlqD	DUF2869;	YlqD protein	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_002915 (release 23.0)	Family	The structure of a representative of this family has been solved (pdb:4dci) and found to form a tetrameric structure of prefoldin-like architecture with the beta-barrel core and helical coiled coil tentacles. This suggests that this family may act as molecular chaperones.	27.00	27.00	27.20	27.60	25.90	25.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.52	0.71	-4.11	29	228	2009-01-15 18:05:59	2008-07-31 16:23:28	3	3	221	8	66	190	120	129.00	34	95.09	CHANGED	lplhRslsVKslVT.phKc-htpplptplspl-pplpQL-hpsp+hlp-hppps.........pQltplppQhspc+schhEp+ppllpQlpQlppLplspEVtpGplEuhhclplGDslhppM.pspIll+DGllpEIR	....hplhpsVsVKtllT-p.Kpclhpphppphppl-p-hpQLchptp+h.pc..p...................pQ.pplppphspchschhEp+cpl..QhpQlchLpLGsElpptplEshhcVplGDshpcph.sspIll+DGllhEIR.............	0	20	49	60
+10901	PF11069	DUF2870		Protein of unknown function (DUF2870)	Pollington J, Finn RD	anon	Pfam-B_002904 (release 23.0)	Family	This is a eukaryotic family of proteins with unknown function.	21.50	21.50	21.50	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.13	0.72	-3.96	21	183	2009-01-15 18:05:59	2008-07-31 16:36:42	3	2	128	0	101	164	1	83.20	47	31.03	CHANGED	cApLWaAGKpL.tcscpLs-Y.lG+NEKTKllVKlpt+spGAPuREPhlsp-pQ+phMthha++QEEhKcLEps--csalsSpWusspuL+pphpGhts.l	................ApLWWAuKEL.tcsKpLsDY.lG.+NEKTKIIlKlpp+GpGsPuREPhlsp-pp+thMhaha++Q............EEhKcLtps-.-cshhsu.WusspsL+pphpGht...............................................	0	32	46	78
+10902	PF11070	DUF2871		Protein of unknown function (DUF2871)	Pollington J, Finn RD	anon	Pfam-B_002884 (release 23.0)	Family	This family of proteins has no known function.	26.10	26.10	26.50	26.70	25.30	26.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.59	0.71	-3.99	17	570	2009-01-15 18:05:59	2008-07-31 16:50:41	3	1	524	0	40	228	0	122.30	48	84.36	CHANGED	MKKlh.suhhYhIlGLluGlFYREaTKhpsFs..GpTpLsllHTHhLVLGhlhFLIhLhL-K.FtLops..phFshFFllYNlGLllTlshhhh+GlhpVhGhsh....ssuluGlAGlGHIlloluhlhFhllLp+ul	....................M++Lh.uhhhYhIIGLhSGhFY.REhTKshsas..G.sTpLslVHTHoLlLGhhhFL...IlLsL-.K.lFpLoph..hh.FshFFhlYNlGlllTluhhss+GhhQVs..Gts.h...........spuhuGhAGlGHshhhsuLlhhhhLL+pu................	0	19	28	37
+10903	PF11071	DUF2872		Protein of unknown function (DUF2872)	Pollington J, Finn RD	anon	Pfam-B_002883 (release 23.0)	Family	This bacterial family of proteins has no known function.	23.20	23.20	23.90	41.70	21.20	23.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.70	0.71	-4.31	31	147	2009-09-10 21:27:12	2008-07-31 16:58:52	3	1	144	0	38	146	453	138.40	54	92.64	CHANGED	YLSGEIHTDWR-cIhpGupt.sLslpFouPVTDHsuSDssG.sILGsEcspFW+D+KuAKlNuIRT+phI-cuDlVVVRFG-KYKQWNAAFDAGaAuALGKslIllHsc-htHPLKEVDAAAhAVscTP-QVVclLcYVhp	.YLSGEIHTDWR-cItcuuct.hsLslsFsuPsTcH-uSDssG.sILGtpsssaW+D+puuclNuIR...........T+phlpcADlVVVRFG-.KYKQWNAAFDAGYAuALGKPlIll+sc-lpHPLKEVcAuA.AsscTscQlVclLpYVh.p.........	1	18	31	35
+10904	PF11072	DUF2859		Protein of unknown function (DUF2859)	Gunasekaran P, Mistry J	anon	Pfam-B_001915 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	25.60	25.20	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.64	0.71	-4.73	34	268	2009-01-15 18:05:59	2008-07-31 17:10:28	3	1	208	0	65	232	4	133.20	41	84.96	CHANGED	ltDhG.GtsshPaapuls.pssp............s.stss.sssspushLPVpSscLo...PGsVptRslp.......hPGh...pPlFLlGDDshSppWLpp+tspLcphpAlGLVVNVsohtsLppL+plA.PGLslhPsoG-DLAcRL...sLcHYPVLITsTG.lp	..........................ltDhG.utss.Phhpsls.p.p..............s..ssst..stushLPVposcLo...PGpVt.tR.slp.......hPGh...tPlFllGDDshSppWLpp+tstL+phpAlGLVVNVpohptLptLpphu.sGl.LhPssuD-LApRL...tLpHYPVLITssul.......	1	8	30	52
+10905	PF11073	NSs		Rift valley fever virus non structural protein (NSs) like 	Gunasekaran P, Mistry J	anon	Pfam-B_001643 (release 23.0)	Family	This family contains several Phlebovirus non structural proteins which act as a major determinant of virulence by antagonising interferon beta gene expression [1].	25.00	25.00	25.80	25.50	22.00	21.20	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.44	0.70	-5.11	15	202	2009-01-15 18:05:59	2008-07-31 17:12:38	3	1	47	0	0	155	0	225.20	55	91.26	CHANGED	PsIspssuhschhsoVsYlsFsp.tspslSsapshEIPlcpaR.uhcpRspLScFhspuEhPtpWGsu...SpVpptssphFDstIpcLuchslcshpR.shPNlccALSWPLGaPohcFFphus.h-sappshppKsshuTpllRh.....Gs.upsLD-slVpsH++lLtEuppRGlsp-hhsGaDlhKEIAhlQhlRllsAlshDhss.....................................sssssslhshlhpp+tshpsp..thlGNppWhPl....s	.........................................VSVEYI+GDGPPRIPYSMVGPCCVFLMHHRPSHEVRLRFSDFYNVGEFPYRVGLGDFASNVAPPPAKPFQRLIDLIGHMTLSDFTR..FPNLKEAISWPLGEPSLAFFDLSS.TRVHRNDDIRRDQIATLAMRS.....CKITNDLEDSFVGLHRMIVTEAILRGIDLCLLPGFDLMYEVAHVQCVRLLQAA.+EDISN.....................................AVVPNSALIALMEcSLh..................h......................	0	0	0	0
+10906	PF11074	DUF2779		Domain of unknown function(DUF2779)	Gunasekaran P, Mistry J	anon	Pfam-B_001581 (release 23.0)	Domain	This domain is conserved in bacteria. The function is not known.	23.10	23.10	23.10	23.60	22.80	23.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.99	0.71	-4.10	49	211	2012-10-03 01:22:09	2008-07-31 17:15:01	3	3	194	0	74	206	203	136.70	28	22.99	CHANGED	halDFEThssAlPhacsspP.YpQlPFQaSlHl.ppss...tp...hpHh.paLs.t.s......hDP+pthlcpLhptlspp................................................................GsllsYNpu.FEpopLpE.huph.........................hs-htphlppIh..............pphlDLhchFppt..................aYcsphpGShS	...............hahDFEoh.p.ulPhacsspP.ap.QlsFQaSlcl.ppss...ts...h.pHh.talt.p.h......tDPRpt....hhppLhphlspp................................................................ushlsYNp.u.FE...ps..pLpc.lAph......................................................hschpptlppIh......................pphlDLhshFppt..................hhpsphpGshS........................	0	34	61	70
+10907	PF11075	DUF2780		Protein of unknown function VcgC/VcgE (DUF2780)	Gunasekaran P, Mistry J	anon	Pfam-B_001695 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.10	22.10	24.10	22.70	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.94	0.71	-4.19	32	234	2009-01-15 18:05:59	2008-07-31 17:15:52	3	1	220	0	62	185	18	154.60	35	91.16	CHANGED	llhhhslhossupA.h.hsshstt.......................tt.htttsspssssspsssLlsslhupLsloppQAtGGhGuLLulApssLuss-aopLuptlPGh-sLhuus...............s..su.suhLsph...LG................sslpuhsslpsAFptLGl...ssshlstFssllhsY.LsppG...sushLhpuLu	.......................................h.hhhhslsussuhA..as..tssts........................ss..ss.ss..tphsps.ttsssLlstlsoQLslospQAsGGsGuLLuhA....p....NpLsusphSpLsphIPGlssLtuss......................s..s................t....Lu................................sltshspVspAFssLGl...DsuMlppFsPllhpYLspQG....ASpsLLtSLu.............	0	13	26	45
+10908	PF11076	YbhQ		Putative inner membrane protein YbhQ	Mistry J, Coggill P	anon	PRODOM_PD083760	Family	This family is conserved in Proteobacteria. The function is not known but most members are annotated as being inner membrane protein YbhQ.	25.00	25.00	26.40	26.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.86	0.71	-4.55	3	433	2010-01-12 15:19:43	2008-08-01 11:37:37	3	1	432	0	22	82	1	131.30	87	98.04	CHANGED	MKWQQRVRVATGLSCWQIMLHLLVVALLVMGWMSGoLV+VGLGLCALYuVTVVhMLsFQRHHEuRWREVGDFLEELTTTWYFGAALIALWLLSRVLHNNLLLALAGLVILAGPAVVSLLAKDKKRastsFuSKHG	..MKWQQRVRVATGLSCWQIMLHLLVVALLVVGWMSKTLVHVGVGLCALYCVTVVMMLVFQRHPEQRWREVADVLEELTTTWYFGAALIVLWLLSRVLENNFLLAIAGLAILAGPAVVSLLAKDKKLHHLo..SKH.RV......	0	1	1	12
+10909	PF11077	DUF2616		Protein of unknown function (DUF2616)	Mistry J, Coggill P	anon	PRODOM_PD264505	Family	This cysteine-rich family is expressed by the double-stranded Nucleopolyhedrovirus, a member of the Baculoviridae family of dsDNA viruses.  The function is not known.	25.00	25.00	81.60	81.50	22.40	21.80	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.54	0.71	-4.77	14	34	2009-01-15 18:05:59	2008-08-01 11:38:50	3	1	33	0	0	29	0	179.10	33	94.21	CHANGED	ME...LIKPFlKYS+hYRsss.ssst..+phlacpWhp-hpppphth.......pshphts.th..........................CpFChs......sppps.......thhCppChFPL..s.......s.cpEhthYsLLSVCYaEssspss.sp.............................+sVWRp................Rl+hsW.p.cpp.+........lYplhhs..................p.ClQCpp......scpsssp.hhpFshchFCppChFPLFpI	...MELIKsFlKYS+tYRsss.sppt...+phlacpWsp-ltspphth.......pphhhpshtt..........................CpaChs........sspps.......thhCcpChFPl..h.p.....s.cpEhthasLLSlCYaEps..sst.....spst...........................+hVWtp......Rl+hsW.st-hstp........hYplhts...............p.ClQCppt.....sppsstp.hhpFshphFC.pChFPLFsI.....	0	0	0	0
+10910	PF11078	Optomotor-blind		Optomotor-blind protein N-terminal region	Mistry J, Coggill P	anon	Pfam-B_595 (release 23.0)	Family	This family is conserved in Drosophila spp. Optomotor-blind is one of the essential toolkit proteins for coordinating development in diverse animal taxa, and in Drosophila it plays a key role in establishing the abdominal pigmentation pattern, in development of the central nervous system and leg and wing imaginal disc-formation of Drosophila melanogaster. This is the N-terminal region of the protein and does not include the T-box-containing transcription factor that plays a part in DNA-binding.	21.00	21.00	21.80	81.10	19.60	20.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.11	0.72	-3.63	3	125	2009-01-15 18:05:59	2008-08-01 11:41:54	3	4	24	0	11	132	0	86.40	95	25.50	CHANGED	suPPsPPYFPAAALAALuGSsAGsHP.GLYPGsLlPKhPPH..huHPHP...HHPL.GuAYTTAEDVVLAAVAAHQHHPAM.RPLRALQ	....Q.QPPPPPY.FPAAALAALAGSPAG..PHH.PGLYSAAGGLRFPPH..PGHPHPHSHPHAHHPL..GSAYTTAEDVVLASAVAHQLHPAM.RPLRALQ	0	3	3	8
+10911	PF11079	YqhG		Bacterial protein YqhG of unknown function	Mistry J, Coggill P	anon	PRODOM_PD123329	Family	This family of putative proteins is conserved in the Bacillaceae family of the Firmicutes. The function is not known.	25.00	25.00	41.30	29.50	21.40	22.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.56	0.70	-5.57	11	186	2009-01-15 18:05:59	2008-08-01 13:12:26	3	2	165	0	35	146	0	223.40	52	94.96	CHANGED	MpQp-IHpFLpRaFpANsCsIlEcSPuahTVQLTlEMDKcLMNRPFYWHYLEKTGGlPNPMpLTLITcppcss-slcGEhIHFGSPRLaQIFpus+chGualRLYEphssssstpsPLcPWLGhNlKlSYQCDRKKDhllSlGLpLIsGpllEsFa-+LpphsLoscIPDYCFTlSPlIKPcSGlpRlcphlcshhcs-sc-WAcpAhcRWpcDLcLL-pFYEcsEEKPEsYclEKpALcc.YEP+IplsllNGGLFYLp	.................M..tpl.pah.pahts.ts.hhptt.thhpVQLoh-MDK.LMNRPFYWHYlEKTGGsPNPM+LTLITssEs.tps.-....GEhIHaGSPRLHQIFposKchGuaIRLY...Ecl.....c.......ps...u........us...c...sPLc..PWLGlNlKlSYQCDRKKDhLhSlGlHLISGThhtsFH-pLpplcLTP+IPDaCFTlSPlIKPpSGlpRlEshLcshlup-DHsWAcEA+hRWpcDLsLLs+FYE.....-.........s.........-Eh.....P.........Es....YclEKpA.Lpc...QYEP+IslpIINGGLFYl.p.......................................	0	10	23	25
+10912	PF11080	DUF2622		Protein of unknown function (DUF2622)	Mistry J, Coggill P	anon	PRODOM_PD066031	Family	This family is conserved in the Enterobacteriaceae family. Several members are named as YdiZ, a putative cytoplasmic protein. The function is not known.	20.80	20.80	21.10	20.80	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.00	0.72	-4.13	7	726	2009-01-15 18:05:59	2008-08-01 13:13:26	3	1	473	0	30	125	0	88.60	52	98.26	CHANGED	Musu-lTRYVlTVpaHE-oLTEINELsNHLTRsGFlLThsD--GslHELGTNTFGLlSu.St-ElptLsuGLupuALsKcs-IsVsTaE-WtKs.p	......ups-lspYVlohhhpEssLTElNELsNhLTRsGFhLThsD--Gs.HELGTNTFGllSop.ut-EI+-LlsuLspsAss+Ds-loIsTa--a.pt..p..................	0	2	3	17
+10913	PF11081	DUF2890		Protein of unknown function (DUF2890)	Mistry J, Coggill P	anon	Pfam-B_629 (release 23.0)	Family	This family is conserved in dsDNA adenoviruses of vertebrates. The function is not known.	23.30	23.30	23.60	24.10	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.72	0.71	-4.23	18	154	2009-01-15 18:05:59	2008-08-01 13:32:05	3	4	79	0	1	180	0	167.20	35	88.93	CHANGED	MsP+tps.KpLtsp.sPsc.........D.EEpWD..SQA.......tEEthE-W............DSL-E-.pEtE.EVEEtsssp.....phssoSsu.utSpsstSsPspsst...h+sp...pRWDpTuphssPossusss...................................................thstpc.suhRph+NpIhssL....QpSpGp.............tShTRp.hLYH+u.s..p+sLc.hctLaspYCuhs	....................................................................................................hp.s...p.............-.EEpW-..SQA.......pE-phE-.............tS.t--tE.E.hE..El-Etpssp..............ss..ss...t..s..sssspssh.osPstsst.......+ss...pRWD...pstt..ssst...t..ssttt...........................................................thp.tpshpShRth+stIhssL.....QpstGp................hShTRp.hLaH+u.s..ppsLc.hctLas.aht....................................................................	0	0	1	1
+10914	PF11082	DUF2880		Protein of unknown function (DUF2880)	Pollington J, Finn RD	anon	Pfam-B_001492 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.00	93.20	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.71	0.72	-4.09	3	5	2009-01-15 18:05:59	2008-08-01 13:35:43	3	1	5	0	5	5	0	78.80	60	65.78	CHANGED	lMAAulhhASuAsAAsslEhP+PRGKDEAPEAPVACMKAVKAALPNPDpFKWVuGTsRKVAEDAYSVVADVEYLupDGA	...lMALSlhsASuAsAAussEAP+PRGKDEAPEAPVACMKAVKAALPNPASFKWVGGTsRKVAEDAYSVVADVEYLAQDGA	0	0	1	3
+10915	PF11083	Streptin-Immun		Lantibiotic streptin immunity protein	Coggill P	anon	Pfam-B_43518 (release 22.0)	Domain	Streptococcal species produce a lantibiotic, streptin, in a similar manner to the production of nisin and subtilin by other lactic acid bacteria, in order to compete against competing bacteria within the environment. The immunity protein protects the bacterium from destruction by its own lantibiotic. In general, there is little homology between the immunity proteins of different genera of bacteria.	20.70	20.70	20.90	23.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.12	0.72	-4.01	12	173	2009-01-15 18:05:59	2008-08-01 13:38:42	3	2	152	0	7	87	3	96.80	46	22.38	CHANGED	IAplDl+LsphpEKIATLNKMAEVLlNLpSc-.po++LA+Y-FSKLNLTEoloLEpVpcEIphLQppLshhlDcYEphlR+L-pFVclLN..hsctht.ca	.............IAElDhcLppsQEKIATLNKMAEVLINLKS-sppo+KLA+Y-FuKhNhTESIpL-plscEIhcLQpELup.lscYEclsR+L-pFlKllN..hsK...................	1	1	3	4
+10916	PF11084	DUF2621		Protein of unknown function (DUF2621)	Mistrey J, Coggill P	anon	PRODOM_PD086666	Family	This family is conserved in the Bacillaceae family.  Several members are named as YneK. The function is not known.	25.00	25.00	25.50	25.50	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.83	0.71	-4.50	12	164	2009-01-15 18:05:59	2008-08-01 13:46:17	3	1	163	0	32	112	0	136.90	71	96.97	CHANGED	M....LpG..WFhhFILhWsllLlsLhuIGGFFMFRKFLKRLPKEDGKS.LDWp-aYI-pT+HLWs-EpKpLLpELVpPVPELFRDVAKpKIAGKIGELALcEcAspIsp-LlIRGYIlATPKRDHKFLhK+LpE+pIDhuPYEpLh	.......LpGWF.WFIlhWsVlLlGLMSIGGYFMFRKFLKRLPKEDGhShLDWpEaYIsKTRHLWsDEpKQLLEELVSPVPELFRDVAKuKIAGKIGELALpEpAopITpDLII+GYIlATPKRDHKFLlKKLpEKcIDaosYpsLL........	0	11	23	26
+10917	PF11085	YqhR		Conserved membrane protein YqhR	Mistry J, Coggill P	anon	PRODOM_PD101610	Family	This family is conserved in the Bacillaceae family of the Firmicutes. The function is not known.	26.00	26.00	38.90	37.50	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.25	0.71	-4.73	12	156	2009-01-15 18:05:59	2008-08-01 13:48:14	3	1	155	\N	28	109	0	166.00	51	98.23	CHANGED	M......sppppphcpppppp.hohhs+slhhGFsGGVhWShluYlsahFsFoEluP.NhlLpPaslG-WKcshlGshluIlhIGllSIusAFLYashL+KlcuhWsGllYGlhLWhlVFalhNPlFPsl+slp-LshsTllTTlClYILYGlFlGYSISaEhNEhp..ppp.t....tppp	.......................pphts.....................pphl.pIGhFGGlFWGuIhYhhalFsFTEsuP.NalLhPFAhGuWK-GshGNllGIVshGLLSIllAFLYpAhLtKFcGlhPGllYGLhWWuLLFauhG.lhPslKosh+Ls+-TIVTTICIFILYGVFIuYSlSatsNsp+tcpEt.t+s.....c..........	0	6	18	20
+10918	PF11086	DUF2878		Protein of unknown function (DUF2878)	Pollington J, Finn RD	anon	Pfam-B_001539 (release 23.0)	Family	This bacterial family of proteins has no known function. Some members annotate the proteins as the permease component of a Mn2+/Zn2+ transport system however this cannot be confirmed.	20.90	20.90	23.00	23.00	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.18	0.71	-4.22	59	319	2009-01-15 18:05:59	2008-08-01 13:54:18	3	1	313	0	84	276	229	151.30	30	86.58	CHANGED	hthllNhlhFQhsWhhsVlhs.sphhhhhhhh.....lhhHhhh......s..phts-hphllhlsslGhhlDulhhthGlhpF.............ssshhPl..WLhhLWhhFuhslspuL.saltphsh.lhsllGuluGshSY.hAGt+luA.VphshshhhohhlLulhWullhPll	....h.hhlhsslhFplhWhhuVlut..p...p.hhhlhsll.........llhphhh......s..pttsphphhlhhsllGlhlDohhhhhGlhsF.............ssshhPl....WLlsLWhsFuhhhs+.L.shlpphsh.lhslhGulhGslSY.asGh+.huA..VphshsshhshlsLsltWsslhsl...........	0	18	34	64
+10919	PF11087	DUF2881		Protein of unknown function (DUF2881)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function. Some members are annotated as p34 however this cannot be confirmed.	25.00	25.00	115.60	115.30	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.65	0.72	-4.49	2	14	2009-01-15 18:05:59	2008-08-01 14:59:55	3	1	6	0	0	2	0	54.00	75	88.52	CHANGED	Ms-FstsllTllTAIIGVAIlAVlVSppSNTAGVIpuuouGFSshLtoALuPlh	Ms-FstsllTllTAIIGVAIlAVlVSppSNTAGVIpuuouGFSshLtoALuPlh	0	0	0	0
+10920	PF11088	RL11D		Glycoprotein encoding membrane proteins RL5A and RL6	Pollington J, Finn RD	anon	PRODOM	Family	RL5A and RL6 are part of the RL11 family which are predicted to encode membrane glycoproteins. Two adjacent open reading frames potentially encode a domain that is the hallmark of proteins encoded by the RL11 family.	25.00	25.00	25.20	33.50	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.38	0.72	-4.18	4	33	2009-01-15 18:05:59	2008-08-01 15:20:20	3	1	5	0	0	28	0	87.50	44	92.09	CHANGED	hpKLpsopGcNlTIscccD.hoTcWcph..ssGst.LCNVTupGssllNs..TlCVSSCoHTSLsLCNhTpts-ulaslG+hhs...DE.sGELWhloVS	.................hp+LpsopGcNlTlscc+c.hootWcpa......D.sG..st.LCNVTupsssslNo..ohCVosCuHooLsLCNhTpts-uhaslu+hhs...DE.sG-lWhlpVp............	0	0	0	0
+10921	PF11089	SyrA		Exopolysaccharide production repressor	Pollington J, Finn RD	anon	PRODOM	Family	SyrA is a small protein located in the cytoplasmic membrane that lacks an apparent DNA binding domain. SyrA mediates the transcriptional up-regulation of exo genes involved in the biosynthesis of the symbiotic exopolysaccharide succinoglycan. It does this through a mechanism which requires a two component system [1].	25.00	25.00	25.50	25.50	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.81	0.72	-4.15	6	37	2009-01-15 18:05:59	2008-08-01 16:07:23	3	1	26	0	17	35	0	37.80	45	41.27	CHANGED	AlAsYFsotShhsAhVsTLsCulLLQluYFluVLFLla	.AlAoYahstShhsshlpTLhCuVLlQlGYFhuVLhLVh....	0	1	6	9
+10922	PF11090	DUF2833		Protein of unknown function (DUF2833)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function are found in the bacteriophage T7. Some of the members of this family are annotated as gene 13 protein.	25.00	25.00	26.70	26.30	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.78	0.72	-3.82	5	41	2009-09-11 15:53:06	2008-08-01 16:15:47	3	1	38	0	0	34	35	84.80	42	57.97	CHANGED	ssVshslsGhVLAIGGNpGDpVWFVTSchVa+LocKpKREFRKLIhEYRDtML-Q.YsoIWNYVWVGNKSHIRFLKoIGAVFHcEaT	................lsh.hhGhslAIGGss....u.spsWFlTSspV...h....phstpt+hcFR+hlhcahDphLcp..Ysp.LWNaVWsGNpuHIRFLKolGAh..Fcp-........	0	0	0	0
+10923	PF11091	T4_tail_cap		Tail-tube assembly protein	Pollington J, Finn RD	anon	PRODOM	Family	This tail tube protein is also referred to as Gp48. It is required for the assembly and length regulation of the tail tube of bacteriophage T4 [1].	20.20	20.20	20.30	20.50	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.01	0.70	-5.74	8	48	2009-01-15 18:05:59	2008-08-01 16:25:33	3	1	47	0	0	41	153	313.60	32	90.19	CHANGED	+VK-.Is.csschhtuh.uupssAGtsocsc..ssophhsAQFPspRAuGNDsst.a.lsDLYKNGLLFTAYshouRsos....sLRshRp.....ssssIhSptsusVpsphstho...........tshhsppAlANILLPRSpSDVDssSH+FND.....ls-SLls+GGuouoGsLSs.......hASTAlaGuLESITpGhhAD.........suEQIYssoRoMYuGu-sRTKsasWpLTPRShpDLhpIlpIYchFshaSYGpoutSphAtElKuplDshY+sThhc.hss.sshpNpT........LhEtIT.uFLoNVhVVSNPslWhI+NFGsooua.....-shp-sFGPsQIpSlRFDKTPDGpFNGLAluPNLPSoFsLElTFREIIsLsRuo	........................................................................................h...hhs.htt..stt.suG..o.tt....pthhsAQaPstRsuusDss..h.hssLYpNGLLFoAashsup.os....phRs.Rp.....ttp..phhp.tttssl..th.t.s..............hspps.l...ssILhPRupoDs-ssSH+FND.....Vt-SLls+Guuouo.GhLSN.................hAST...AlaGulE.......Slo.......p.GhhAD........................pGEQlhssu+uMYsGs-sRTKsFoachoPRshpDLhpIlpIYchFp.....hhSYGpsGpSp..hAt-..l+s.lDshY+sThhp.h.....s.s.tsps...............hhEthT.uhloNV..hVlosP...slW...hl+sFu...pssph.........-shp-hF...GPstIpSIRhsKoP-GpFsuLA...huPNhPS...o...hsLElThpEllsLsRu.......................................	1	0	0	0
+10924	PF11092	Alveol-reg_P311		Neuronal protein 3.1 (p311)	Pollington J, Finn RD	anon	PRODOM	Family	P311 has several PEST-like motifs and is found in neuron and muscle cells. P311 could have some function in myo-fibroblast transformation and prevention of fibrosis [1]. It has also been identified as a potential regulator of alveolar generation [2].	25.00	25.00	56.20	56.10	20.10	16.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.27	0.72	-4.01	4	38	2009-01-15 18:05:59	2008-08-01 16:31:11	3	1	24	0	16	33	0	62.60	68	93.40	CHANGED	MVYYPELhVWVSQEPFPsK-MEGtLsKGRLPVPKEVNRKKpsEstAASLsPlGusEh+SPtIuYLHsF	.MVYYPELhVWVSQEPFPNK-MEGRLPKGRLPVPKEVNRKKssETsAASLTPl.GSs..EL+SPpISYLH.F......	0	1	1	3
+10925	PF11093	Mitochondr_Som1		Mitochondrial export protein Som1	Pollington J, Finn RD	anon	PRODOM	Family	Som1 is a component of the mitochondrial protein export system. The various Som1 proteins exhibit a highly conserved region and a pattern of cysteine residues [1]. Stabilisation of Som1 occurs through an interaction between Som1 and Imp1, a peptidase required for proteolytic processing of certain proteins during their transport across the mitochondrial membrane [2]. This suggests that Som1 represents a third subunit of the Imp1 peptidase complex [2]	21.40	21.40	22.70	22.10	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.04	0.72	-4.18	10	77	2009-01-15 18:05:59	2008-08-01 16:33:09	3	1	76	0	57	72	0	83.00	31	76.66	CHANGED	MAPPTPVhotcElppphssthpsstch......cCpLKSLTQaECsF+so.tts....sEhICLPFKRLFpcClhP.............c+hlNIElTDppTN	.............................MuPP...sslhstppl.tphtp..pt.tph..............pCp.LhplsQapCsh..css.......t.......stll.ChPhpRLFc+C...........................ts.thslEsTshpt..................	0	9	30	48
+10926	PF11094	UL11		Membrane-associated tegument protein	Pollington J, Finn RD	anon	PRODOM	Family	The UL11 gene product of herpes simplex virus is a membrane-associated tegument protein that is incorporated into the HSV virion and functions in viral envelopment [1]. UL11 is acylated which is crucial for lipid raft association [1].	20.30	20.30	20.50	43.60	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.80	0.72	-4.14	11	49	2009-01-15 18:05:59	2008-08-01 16:39:40	3	1	32	0	0	40	0	39.80	52	42.96	CHANGED	MGQusStutss....CCR..pNhLlTcsGEsluLsA-sF-sF-L....-	MG.uhSsupss....CCR..pNhLlTcsGEVVoLsAcsF-shDlE...........	0	0	0	0
+10927	PF11095	Gemin7		Gem-associated protein 7 (Gemin7)	Pollington J, Finn RD	anon	PRODOM	Family	Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE [1].	21.50	21.50	23.30	30.60	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.50	0.72	-4.24	7	68	2009-01-15 18:05:59	2008-08-01 16:52:05	3	2	59	2	45	74	0	78.10	46	57.14	CHANGED	popEQ+tRusLRERaL+SL.sMss+sssFThHEtsp..VsApFtAoDlsltNFhVSpLpTPIGlpsEAlLRsoDllSaTFcs	............pEQcARuhLRERaLRo...LluMs...G+p.VsFs..LHEslc..VsA.cFsAoDlDltNFhVSpLpTPlGV.Q.sEALLRssDIIuaoFc......	0	15	19	34
+10929	PF11097	DUF2883		Protein of unknown function (DUF2883)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins have no known function but appear to be restricted to phage.	25.00	25.00	30.40	30.30	19.00	16.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.67	0.72	-3.86	3	35	2009-09-11 15:42:54	2008-08-01 17:04:17	3	1	34	0	0	22	0	73.20	86	100.00	CHANGED	MLNNNVVYLGYPGLPPNKLEGLMLELRTVARCSGLEFRFQDTPRRGKNYTQMHILKQRSKTGAFVMHYKPRKEKF	MLNNNVVYLGYPGLPPNKLEGLMLELRTVGPSSGLEFRFQDTPpRGKNYTQMHILKQRFKTRAFVMHYKPRKEKF	0	0	0	0
+10930	PF11098	Chlorosome_CsmC		Chlorosome envelope protein C	Pollington J, Finn RD	anon	PRODOM	Family	Chlorosomes are light-harvesting antennae found in green bacteria. CsmC is one of the proteins that exists in the chlorosome envelope. CsmC has been shown to exist as a homomultimer with CsmD in the chlorosome envelope [1]. CsmC is thought to be important in chlorosome elongation and shape [1].	26.30	26.30	26.70	126.80	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.47	0.71	-4.47	5	13	2009-01-15 18:05:59	2008-08-04 09:12:01	3	1	13	0	11	12	0	138.80	73	99.18	CHANGED	MSESYQKLRKDFKDLEFTDRLTFLAEGsLLTGQSAVVGGLELAGSVVETVAGTVGSLlDATGIG+LLGsTGGVVGETIDRVAITVKDVSRSAGELYSDAVKNVENVTDNAA+AIGDAGVSASEAVKNlsGSFQKosGKK	MSESYQKLRKDFKEL-FTDRLTFLAESlLLTGQSAVVGGLELAGSVVETVuGTVGSLlDAoGIGslLGsTGGVVGETIDRVAITVKDVSRSAG-LYsDAV+NVENVTsNAAKAlGDAGVSASEAVKNlAGSFQKssuKK..	0	1	2	8
+10931	PF11099	M11L		Apoptosis regulator M11L like	Pollington J, Finn RD	anon	PRODOM	Family	Apoptosis regulators function to modulate the apoptotic cascades and thereby favour productive viral replication. M11L inhibits mitochondrial-dependant apoptosis by mimicking and competing with host proteins for the binding and blocking of Bak and Bax, two executioner proteins [1].	25.30	25.30	25.40	42.40	24.70	25.20	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.96	0.71	-4.51	9	129	2009-01-15 18:05:59	2008-08-04 13:01:09	3	1	37	6	0	96	0	160.50	52	77.66	CHANGED	+sllh........................hYlsctslsc....LsshEpslLshIppsC-hIppsYppshs.lss.hlchsshSh.sIpcIKsplhpsLhsDspPSVKLAolSLlShIhc+hh..scslhh.shlhs-IhstIotptcplIsFIpcppc.sss...h...cphlplhshhshh.hlsYhhlKahh	.p..hVY........................YYhsKpRLD-hYRpLsopoRSalDlIshhCDKlNNDYs+DhNlMYD...hASscSa.slhDIsNEV.soILhsspulGVRLATISFIopluKRshNslcTI+MhoLLScsIsD......-pFlDYIschs..ssss..s.hpT.Rchl+lhGlssIh.FsTYtsLKYh.......................	0	0	0	0
+10932	PF11100	TrbE		Conjugal transfer protein TrbE 	Pollington J, Finn RD	anon	PRODOM	Family	TrbE is essential for conjugation and phage adsorption. It contains four common motifs and one conserved domain [1].	25.00	25.00	74.40	74.20	22.10	19.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.32	0.72	-4.12	4	124	2009-01-15 18:05:59	2008-08-04 13:04:03	3	2	103	0	2	68	0	65.30	77	78.99	CHANGED	+llsFLlRLolTlIVISPslYWSWDsVKsTTA-DhlhAsllIhhsGlhhhlLYhFhslLTKlhptD	..RFIDFLIRLLITAIVISPVIIWSWDTVKETTADshLAAAFVILYSGVL.LFILYFCFSALTDLQKs....	0	0	0	1
+10933	PF11101	DUF2884		Protein of unknown function (DUF2884)	Pollington J, Finn RD	anon	Pfam-B_001481 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.	30.60	30.60	31.30	32.70	29.20	29.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.31	0.70	-4.98	39	793	2009-01-15 18:05:59	2008-08-04 13:22:51	3	1	717	0	94	390	15	209.20	48	88.49	CHANGED	CsVslpt-lhlsspplplhpsss.......pphhIspsspLalsGcplsLsscQpptlppYppslpptlPplhplAp-ulplApsAlsplhsshhu..spshsplpphhsplptplpphhhppssphhhsspthst....hpp.appchEpthcphlppShGolhhslusph.....tpGs....phsshtpphssltppl-pphcppupsl-t+AcplCsplpsLsp.EppLpttlPpLtshplhp	........CSVoP+DDVIlSPQoVQV+GcNG........NLVIo.PDGNVhhNGKphoLsAAQRcQA+DYQucLRSsLPWID-GA+sRVEKARlALDKlIspphG...psSphRuRLTcL-AQLKpQMNRIIEpRoDGLTFHacAIDQ.............VcA....-GpQLVsQuMGGILQDSlNEMGsK..tshcuGG......NPLQ.slhGSLGGLQsu.IQsEWKpQE+DFQQFG+-VCuRVsoLE-sRKAL..............sst............	0	12	31	60
+10934	PF11102	Cap_synth_GfcB	DUF2886; Cap_synth_GfcC;	Group 4 capsule polysaccharide formation lipoprotein gfcB	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_1366 (release 23.0)	Family	This family includes lipoprotein GfcB (YmcC), involved in group 4 capsule polysaccharide formation [1].	20.20	20.20	20.20	21.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.13	0.71	-4.76	39	859	2009-09-11 10:59:46	2008-08-04 13:41:14	3	1	602	2	69	362	161	193.80	52	91.11	CHANGED	LsuCopp.........hpshssolphuh.............hsstssslospplps.sshsshhhplsstspshhlLshs-p...............hpWhosDpthlshcsGhllpTpuLss..sLhus..............pssshhthhpt.....ssstshphphphsst........chshh.hpsphph.upcsltlstt.shpshchpEpsphs........stp....apNpYWl-sssGp....llpScQhluPshshlphphL	...............................LpuCoto.............ppplssolhsSL................FGssslploDp.p.IQs.hPYAS.Yhp.LNsGsplFVVLAasEs...................sQpKWlo.QDpAhLVTppGRLVKTl.hhss..NLlEVs...........N.usDPLhpshpI.......hDGusWTRshsWoEt.......pph..RhATspSsFp.asGs-Tlpluuc...cshspVhsEEVoos............ptpWpNpYWlD.S.pGQ....lRQScQhLGAshhPVchTh.....................................................................................	0	8	27	49
+10935	PF11103	DUF2887		Protein of unknown function (DUF2887)	Pollington J, Finn RD, Bateman A	anon	Pfam-B_1330 (release 23.0)	Domain	This bacterial family of proteins has no known function. These proteins may be distantly related to the PD(D/E)XK superfamily.	22.40	22.40	22.70	22.60	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.13	0.71	-4.71	29	232	2012-10-11 20:44:46	2008-08-04 14:02:13	3	5	44	0	85	297	45	160.80	36	68.55	CHANGED	TDslFY+LFpp.PshlFELls.pssspAcsYcFsSVElKppsFRlDGVFlPhtst.stPlaFsEVQFQpDpphYpRlFAElaLYltppp.p.scWpuVlI....YssRsl-.sshhsacplLsuspVpRlYLsELsshpp.slsluLltLh.lhspppssppA+hLlppsp.....pphhsttppppll-lIpTIllYKFsplS+cElcAML	.........................TDplFYplFtp.PphhF-L..ls..sstpsp.YpFsShplKphtFRlDGlFhP.tp...s.PlahsEsQhQ.DtthY.RhFsElalYltp.p...psWpslll....ass+ph-......t.......apthlp....tp....l......p.RlYL....s....-.....Ltp.....t.s.lslu.h.l.pLl..h.sptps.ppuptLlppsp.....pp........ppllpLIEoIllYKhPphoccElptMh......................................	0	5	66	85
+10936	PF11104	PilM_2	Competence_A;	Type IV pilus assembly protein PilM;	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Family	The type IV pilus assembly protein PilM is required for competency and pilus biogenesis [1-2]. It binds to PilN and ATP [3].	66.50	66.50	66.50	67.00	66.40	65.90	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.87	0.70	-5.56	37	952	2012-10-02 23:34:14	2008-08-04 14:34:40	3	4	881	1	318	846	348	315.90	25	86.32	CHANGED	GlDIoSouVKllELoc.ps..spa+lEsaAhtslPcsuls-tsIt-h-uVucsl+plhcctssps+psAhAVsuSuVITKhI.hsusLs-pELEsQl.chEAspaIPasL-EVslDFpllG.s...tsssscVcV..LLuAsR+EsV-sRlssl.....-tAGLpscVlDVEuaAlpR.Ahphlhpp........Lsssspsp.....sVA.............llDIGAshTslsVlpsGphlYsR-QsFGGpQLTppIt+pYGhohEEApttKppGsLPc.............sYp.-lLpPFhpslsQplsRuLQFFhoooths.pVDtllLuGGsAsl.GLschlppclGhsThlsNPFtsMplusc.lptptLpp-usuhhlAsGLALRuF	.............................................GlDIuspulKhlpLp......t....pt.....sp....hplppauhhslPts....sl.s....-s.p.....lh-h.pt...l........sptlpchhpph...s.h.p..s+.pss.h..ul..ss.s.s.V.Is+.hlp.hss.sh....s-.c-.lEt.t.l.phEs..sphl..P..a..s.l-E..lsl.Daph.ls.p..................s..ss..s...p..h.....pV..LlsAs++-.l-shhssh.....ptA..GLpshll..D.V..csaAlt.p..sh.p.....h....h..tp.......................hs.t.t.....t..tt.....hls...................llDlGu.shoslslhpsup.hl.a.pR....ph..s.hG.u.ppls.ptlt......pt..h.....s..l.s.h...ppA...........t.......h.h...t.....p.....t....s....l.....sp.....................................s..h..........p....s....lp.....h...hp.p...lspplpRsl...paa..h...s...s...s...t..tp...p................lsp..lhLsG.G.sutl...GLsphl.ppp.hshss.hhs.Ph..t....h.th.s.p...p..p.....ht.ptst..hhhuhGLAhRt.....................................................................................................	0	121	226	283
+10937	PF11105	CCAP		Arthropod cardioacceleratory peptide 2a	Pollington J, Finn RD	anon	PRODOM	Family	CCAP exerts a reversible and dose-dependant cardio-stimulatory effect on the semi-isolated heart of experimental beetles. CCAP also increases free hemolymph sugar concentration in young larvae and adults of the meal-worm beetle [1].	20.20	20.20	21.20	35.90	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.81	0.71	-4.43	4	47	2009-01-15 18:05:59	2008-08-04 14:41:47	3	2	33	2	22	50	0	102.10	32	82.57	CHANGED	hpsohshLLhLlshlhC....l-CuhssppPRsacthssEs...ss......pKRPFCNAFTGCG+KRSpsssss.......PsshhpRp.........-.lppc..sNE...EuLusLlDLNoEPAVE-L.RQIMSEAKLWEAIQEAs+EIahQKptpK..p	..........................................h.hhhhhh.....h.ss.s...h..p..p..p...tp..............pKRPFCNAFTGCG+KRop.......................................p....tshtsh..hps-.t.-pl.+QhhopsKlaEsIpEAphEl..pppt...................................................	0	10	12	19
+10938	PF11106	YjbE		Exopolysaccharide production protein YjbE	Pollington J, Finn RD	anon	PRODOM	Family	YjbE is part of a four gene operon which is involved in exopolysaccharide production. The expression of YjbE is higher than the rest of the operon yjbEFGH. It appears to be restricted to Enterobacteriaceae [1].	25.00	25.00	26.40	26.00	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-9.89	0.72	-4.01	2	379	2009-01-15 18:05:59	2008-08-04 14:48:45	3	1	368	0	17	71	1	79.80	92	99.09	CHANGED	MKKlL.GlFAIsALuAsSspAAPVpVGEAAGSAATSVSsGSSSATusSTVuSsVGVALAATGGGDGSNTGTTTTTTTSTt	......................MKKVL.YGIFAISALAATS.AWA.....APVQVGE...AAGSAATSVSAGSSSATSVSTVSSAVGVALAAT.G..GG....DGSNTGTTTTTTTSTQ......	0	1	1	13
+10939	PF11107	FANCF		Fanconi anemia group F protein (FANCF)	Pollington J, Finn RD	anon	PRODOM	Family	FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [1].	21.10	21.10	22.50	22.50	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-12.16	0.70	-5.19	7	69	2009-01-15 18:05:59	2008-08-04 14:58:34	3	3	50	1	39	61	0	285.20	27	85.35	CHANGED	M-slLcplctFl-lLslu....postVtsWD.tsl+RAhpWAtYhcpla++hpspsslcpuLppcLpst.pp.uss..hPs.hp.hsFpsLupscpllhhpLLpN.sltstph.hll.pL.......s.pt-t-sLpsshsphssp+ushphL......................phsutppssphppsohhpsp.................uclLhchLpchhp..sps.cpstphLspLh..cth.pssahpllAssLLpssss.pp.p.............spchLlpWLht...psshhssFCp.l.utLLsploh+hsphpshYhshLpphupph..........................ph-l.cuhhlusEsp.hsa-tLhp+hpuL..hpus.sl..pptshssLcshptQD....Gs.pl.GhSlWsDlhLtLt	.................................MEtlLpplctFs-lLslu....postVpsW-stslcRAlpWApYhcclac+htpp.stlR.pulpccL..cst.tp..sss.....hs...t.h......shpsLupsc.ll.hpLLpN.sL.....tstththll..ph..........s.p.p.ptl..tphsphhppc.s.phL.....................................ps.htsp.................uplLhppLpphhp.....hps.p.stphL..splh...pth.ps..s..hhp.hAssLL.........s.....p.........................pp.llpWLht.................thhtshCh...shlLs.hs.+hstht.hhhshhpphhphh...........................h-l..cthhlss...tsp....appL.hp+h.sL..hpus.sl..ppts.ptLpthptpD.......ps......pDhh.th...............................................................................................................................	0	7	13	24
+10940	PF11108	Phage_glycop_gL		Viral glycoprotein L	Pollington J, Finn RD	anon	PRODOM	Family	GL forms a complex with gH, a glycoprotein known to be essential for entry of HSV-1 into cells and virus-induced cell fusion [1]. It is a hetero-oligomer of gH and gL which is incorporated into virions and transported to the cell surface which acts during entry of virus into cells [1]	25.00	25.00	42.00	41.60	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.70	0.72	-4.09	9	36	2009-01-15 18:05:59	2008-08-04 15:34:02	3	1	25	16	0	30	0	109.10	32	71.22	CHANGED	PCCpl.sLstsp.lPulasIssIalssspo.CsGhslApL...+ptsspsTh...phCuNGFNlhSFhlulLp+ls.ss.tEphcLLstLpp.hsuF.lsshpsssssu.thp....uhpG	.PCC+I..psh..sspp.hP..thasIssIaLssspp.CsGhslApL...+ppssphsh...phCsNGFsLhuFhlullp+h.s.ss.t--lcLLstLpp.hssF.hpsFpssssNuSth.....hss.....	0	0	0	0
+10941	PF11109	RFamide_26RFa		Orexigenic neuropeptide Qrfp/P518 	Pollington J, Finn RD	anon	PRODOM	Family	Qrfp/P518 has a direct role in maintaining bone mineral density [1]. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice [2]. The c-terminal 28 residues are the functional 26RFa [3].	25.00	25.00	39.20	39.20	23.70	21.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.78	0.71	-4.26	3	30	2009-01-15 18:05:59	2008-08-04 15:46:31	3	1	27	0	16	31	0	123.40	60	97.11	CHANGED	hRPYsLlYhLFLPLGACFPLLDRREPTDAlGGlGAcMsWADLAcG.RPas.WGSPsWlRAPQPQALLVlARELQASGREHAGhpFRLGRQD-GSEATGFLPA-uEKsSGPLGTLAEELNGYSRKKGGFSFRFGR	...........tsasLshL.LhLPLGsCFPLLDR+pPsDshGshGu.thsWAcLAtG.+..P.as.W..Gus.pWhRAspPpALLVlA+tLQsSGRE+AGhpFRFGRQD-GSEAsGFLPAs.uEKsSG.PLGsLAEELNGYSRKKGGFSFRFGR	0	1	1	4
+10942	PF11110	Phage_hub_GP28		Baseplate hub distal subunit	Pollington J, Finn RD	anon	PRODOM	Family	These baseplate proteins are also referred to as Gp28. Gp28 is the structural component of the central part of the bacteriophage T4 baseplate, which possesses a hydrophobic region and is membrane bound [1]. Gp28 forms a complex with gp27 which is another structural component of the baseplate [1].	25.00	25.00	36.10	35.50	23.00	17.40	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.90	0.71	-4.53	6	31	2009-01-15 18:05:59	2008-08-04 15:49:07	3	1	30	0	0	24	0	148.30	46	84.65	CHANGED	IPKLGlKHh+LLKDh+GsD-sh+lLlDSIpPGLoAAEsDhVhLHLLtFNsKlpohpphDGashclsDlYlCp+hEFpapGpTFaFKsPthh.-pFlohsDhLo+...phsD-ps..-hsFh-hPAFVlcWA--IhoTIAlssPsGsIpGhusIlGll	IPKhGLKHapllKDhKu.P-csL+lLlDSIpP.sLosAEsDFVslHLLEFNGKlpsppplDGasYclsDlYlC.Q.+LEFpapGpTFhF+sPthh.-pFhsls-hLpp....lplsD-sh....c..sFh-MPAFVhcWAs-IhoTlAlsGPNGsIpGlhsIlsl..........................	0	0	0	0
+10943	PF11111	CENP-M		Centromere protein M (CENP-M)	Pollington J, Finn RD	anon	PRODOM	Family	The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A [1]. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins [1]. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival [1].	25.00	25.00	25.10	25.40	24.00	24.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.95	0.71	-5.04	6	65	2009-01-15 18:05:59	2008-08-04 15:53:17	3	1	51	0	36	61	0	158.40	50	95.51	CHANGED	MA...lLRPaDKLPpLNsATlLLVGsE-uhppQLApuML+ccpsFplplHLApSLPLPs-ppphRPRIDLIVFlIsL+SKhSLpsVctSLsHLDssFFLGKVCFLlTGAGpssHCsVchsoVhKLAcoapSPllhs-hchEDhpsAhApRLLphLQICAGhVP.GVSALhLsoLhRsots	...................................MulLpPhsKhPtLN...sAolLLVGsE-thhppLA-uML.+..E.-ss...p..lpVHLAp.SLPLP..sp.ss....RPRIDLIVFVlNL+SK...a..SLpssEpSLpHVDusFFL.GKVCFLsTGAGptspsSl+hssVhKLApoYpSPlLas-Lcsc..shRsshAQRLl+hLplsAGhVP.GlSAL.L.shh+so..s................	0	9	12	20
+10944	PF11112	PyocinActivator		Pyocin activator protein PrtN	Pollington J, Finn RD	anon	PRODOM	Family	PrtN is a transcriptional activator for pyocin synthesis genes [1]. It activates the expression of various pyocin genes by interaction with the DNA sequences conserved in the 5' noncoding regions of the pyocin genes [2].	18.40	18.40	19.60	18.40	17.50	17.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.26	0.72	-4.15	26	221	2009-01-15 18:05:59	2008-08-04 16:51:16	3	2	194	0	36	165	0	74.50	34	80.92	CHANGED	TsahLhApa.upsllPl-cVsp-YF.pl.oscphhcKlpsGcIsLPlh+hc.sSpKus+hVplpDLAsYlDc+tptAc	...............phhhLhtca.ssshlsLptVspcYF.tl.ospshppKssuscl.slPshRls.sSp..Kuth...hVplpDLApYlDc+ppp............	2	6	10	24
+10945	PF11113	Phage_head_chap		Head assembly gene product	Pollington J, Finn RD	anon	PRODOM	Family	This head assembly protein is also refereed to as gene product 40 (Gp40). A specific gp20-gp40 membrane insertion structure constitutes the T4 prohead assembly initiation complex [1]. This protein in T4 stimulates head formation [2].	25.00	25.00	26.50	29.70	24.20	23.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.70	0.72	-4.08	10	33	2009-12-03 14:07:40	2008-08-04 16:51:44	3	1	32	0	0	25	0	55.70	46	51.23	CHANGED	VlQEllIh.c-GpsHLVYIaclpac...DGplplDauTss-t....K-ELtPHVccslphQI	.......VlQEIlIpLcDGssHIVYlpclcas...cG+lslDFuT.s--c...KsELuPHVEKClshQl...	0	0	0	0
+10946	PF11114	Minor_capsid_2	Minor_capsid; Minor_capsid-2;	Minor capsid protein	Pollington J, Finn RD	anon	PRODOM	Family	Most of the members of this family are annotated as being minor capsid proteins. The genomes carrying the genes usually have three similar proteins adjacent to each other, hence this one being named as No.2.	26.40	26.40	26.50	26.40	26.10	26.30	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.51	0.71	-4.21	5	120	2009-12-03 14:36:31	2008-08-04 16:51:54	3	1	116	0	15	97	1	109.60	29	94.67	CHANGED	M.h+IpVDLuGhKcKlSspuh+RG+lAlsNQhhhDMEQYVPhR..-GhLRuSu+lsSsGptIsYoTPYARAQFYGss....staph+NYTTPGTGKRWDhK..AKuhahuDWp+....AFlK.GMG	...........................tlhlcLs...t...hct...pl.p.p.uhp...+u...phtlsspshtshs.YVPhc.......sGpL.+s.o..u...p...l.sss..G...t..lhasssYARtQaYGss..................hphpphssPs...sGt+WDp+..ApsphhppW.c....sh.p.............................................................	0	10	13	15
+10947	PF11115	DUF2623		Protein of unknown function (DUF2623)	Mistry J, Coggill P	anon	PRODOM_PD065638	Family	This family is conserved in the Enterobacteriaceae family. Several members are named as YghW. The function is not known.	25.00	25.00	33.80	33.50	21.90	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.03	0.72	-4.05	6	450	2009-01-15 18:05:59	2008-08-04 17:16:34	3	1	449	0	21	54	0	94.90	86	99.75	CHANGED	MNNHFGKGLMAGL+AspAcoAsclspFCuDYKRGFVLGYoHRMaEpTGDRQLSAWEAGILTRRYGLD+EMVMDFF+EssSshAlRFFhAGYRLEs	....MNNHFGKGLMAGLKA............THAD........SAVNVTKFCADYKRGFVLGYSHRMYEKTGDRQLSAWEAGILTRRYGLD.KEMVMDFFRENNSCSTLRFFMAGYRLEN...................	0	1	4	12
+10948	PF11116	DUF2624		Protein of unknown function (DUF2624)	Mistry J, Coggill P	anon	PRODOM_PD060869	Family	This family is conserved in the Bacillaceae family.  Several members are named as YqfT. The function is not known.	20.80	20.80	20.90	21.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.73	0.72	-3.47	11	138	2009-01-15 18:05:59	2008-08-04 17:17:48	3	1	137	0	21	76	1	84.00	58	88.95	CHANGED	M.hlhQplVpQKLNplTsc-LL+YuKQYGlslTpsQAcplhsll+GKsINIFscsERp+llKclppITuPpTAppVNcLFpQFs.........s	......M.NLI+QlVNKKLNpIosKELLKYSKEY-VPITsuQA-QIVhLMKGKNINIYDssERLcLLKQIAKVTSPuTAQQVNsLFQQLl..K....	0	3	12	15
+10949	PF11117	DUF2626		Protein of unknown function (DUF2626)	Mistry J, Coggill P	anon	PRODOM_PD060869	Family	This family is conserved in the Bacillaceae family.  Several members are named as YqgY. The function is not known.	25.00	25.00	50.50	50.20	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.77	0.72	-3.57	8	157	2009-01-15 18:05:59	2008-08-04 17:19:28	3	1	157	\N	28	77	0	79.60	73	98.46	CHANGED	MDRMFRVLuFWTGIFAVMFYlGDMpssuLLFFGQTuhFlhLuYLpLSERMYlYIFGAYLTVFFlGFTYYSTFlhVPGhGc	.M-RMFRVLGFWTGIFuVMFYlG.............DM........ps.....sALLFlGQTGFFVLLSYLKLTERMYIYlFGAYLTVFFlGFTYYTTFlhVPGuGc.....	0	9	19	22
+10950	PF11118	DUF2627		Protein of unknown function (DUF2627)	Mistry J, Coggill P	anon	PRODOM_PD058321	Family	This family is conserved in the Bacillaceae family.  Several members are named as YqzF. The function is not known.	21.70	21.70	22.20	39.70	21.40	18.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.50	0.72	-3.88	13	153	2009-01-15 18:05:59	2008-08-04 17:19:58	3	1	153	0	29	89	0	77.20	61	95.06	CHANGED	MtRllALllLLIPGslAAlGIKLMRDolFGIlhsPFshL.......WLQFLuGllhFshGlhhlAGFILaRDRKRNKVssRF++	..MpRhlALLlhLIPhulAshGIKLMRDTlFGILh.s.....P.h.u...hL.......WLQFLlGhlhFulGhYlhGGFlLHRDRKRNKVQsRFR+.........	0	10	20	23
+10951	PF11119	DUF2633		Protein of unknown function (DUF2633)	Mistry J, Coggill P	anon	PRODOM_PD053432	Family	This family is conserved largely in the Bacillaceae family. Several members are named as YfgG. The function is not known.	20.90	20.90	21.50	20.90	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.91	0.72	-4.25	7	453	2009-01-15 18:05:59	2008-08-04 17:21:01	3	3	451	0	33	99	7	54.10	73	72.81	CHANGED	hR++hssphT+IlLLISFlhhFGRhlYuuIsAh.HHQp+.pu.phs.olp........pthpp	...KRHRFNoRMTRIVLLISFIFFFGRFlYSSlGAWQHHQsKKE.AQ.QSoLSVE....oP.......sQR.................	0	1	4	19
+10952	PF11120	DUF2636		Protein of unknown function (DUF2636)	Mistry J, Coggill P	anon	PRODOM_PD053231	Family	This family is conserved in the Enterobacteriaceae family. Several members are named as being YhjT, but the function is not known.	21.90	21.90	21.90	23.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-8.99	0.72	-4.47	8	456	2009-09-11 14:18:15	2008-08-04 17:21:37	3	1	452	0	25	86	0	61.90	80	97.67	CHANGED	MslSDIlQLlllCALIFFPLGYLs++shRRlRsThRhhhh+PRYVKPAGsL+Rs........o+V+uscp	...MTISDIIEIIVVCALIFFPLGYLARHSLRRIRDTLRLFFAKPRYVKPAGTLRRT........EKARATKK.........	0	2	4	15
+10953	PF11121	DUF2639		Protein of unknown function (DUF2639)	Mistry J, Coggill P	anon	PRODOM_PD049467	Family	This family is conserved in the Bacillaceae family.  Several members are named as being YflJ, but the function is not known.	21.70	21.70	21.70	25.80	19.80	18.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-7.90	0.72	-4.45	8	197	2009-01-15 18:05:59	2008-08-04 17:22:01	3	1	123	0	16	79	0	41.90	69	77.77	CHANGED	HaGSKGWYVcELKKhGIppaE..GRKLESYKsHhLuNLL..cph	............YaGoKGWYVtELKKLGlRhaE..G+KLESYRsHlLpsLLt...........	0	2	9	10
+10954	PF11122	Spore-coat_CotD		Inner spore coat protein D	Mistry J, Coggill P	anon	PRODOM_PD057197	Family	This family is conserved in the Enterobacteriaceae family. CotD is an inner spore coat protein that is expressed in the middle phase of mother cell gene expression. Along with CotD, CotH, CotS and CotT it is assumed to assemble into the loose skeleton of the matrix, between the shells of SpoIVA and CotE. Coat proteins do not share much sequence similarity between species, but this does not imply they do not share secondary, tertiary, or quaternary features [1].	19.60	19.60	20.50	20.40	18.60	18.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.48	0.72	-3.67	15	144	2009-01-15 18:05:59	2008-08-04 17:22:21	3	1	131	0	25	95	0	100.70	52	82.33	CHANGED	sslVHPT+pssscshscslVPHIHPsHTTpVN+phhcHhHYaPpTpSshspss..................ppahts..sss............................................G+sss	......APVlHPTKQCVsHoFSsTVVPHIaPTHTTHVaHQplK..sQpaF.PQTsSNVNsVs.........................................................................HsHpluPhs..P..ssssushGs..s.................h...........sss...............................................................................	0	6	15	20
+10955	PF11123	DNA_Packaging_2		DNA packaging protein 	Pollington J, Finn RD	anon	PRODOM	Family	This DNA packaging protein is also referred to as gene 18 product (gp18). This protein is required for DNA packaging and functions in a complex with gp19 [1].	21.00	21.00	21.60	50.20	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.62	0.72	-4.10	5	41	2009-01-15 18:05:59	2008-08-05 09:05:58	3	1	31	0	0	31	0	78.70	63	93.67	CHANGED	DKoLIKFLEMLDTEMAQRMLuDLpDDERRSPQLYNAIGKLL-RHKFQISKLpPDEsILGGLAAuLEEYsclVGssGLTDD-h	....hsL.phLEMLDTEMAQpMLtDLpDcE+RoPQLYNAIsKLLDRHKFQIuKLQPDhpILGGLAuALEEYpphVGssGLT-D-............................................	0	0	0	0
+10956	PF11124	Pho86		Inorganic phosphate transporter Pho86	Pollington J, Finn RD	anon	PRODOM	Family	Pho86p is an ER protein which is produced in response to phosphate starvation. It is essential for growth when phosphate levels are limiting [1]. Pho86p is also involved in the regulation of Pho84p, a high-affinity phosphate transporter which is localised to the endoplasmic reticulum (ER) in low phosphate medium. When the level of phosphate increases Pho84p is transported to the vacuole. Pho86p is required for packaging of Pho84p in to COPII vesicles [2].	23.70	23.70	29.40	133.80	20.00	23.60	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.85	0.70	-5.43	10	45	2009-01-15 18:05:59	2008-08-05 09:16:28	3	1	43	0	28	40	0	287.50	41	91.77	CHANGED	QKDssLNcPLDt-APPTltpoSLpPELApAuLsLpuDah+QtQuhhN+alFaHPlslollslslsshluhpL...as.hs.hSsols-.LYphhlhsK+-hlhsllhslsssuhlFuhluh.sahVoDthtchsschltpspsEpIFGhNL+cau............................spchsscs+cl.t........pscNTaIIlYR-oPIAllolssshspSoc-shlh+ITGltlR+ValKushh-sLIDWAhlRoRplhp-a.psK........upSlplllDsYSFDpphcKhLtp+GFphlp.ShcLss............clL.....ssLFGIo+-TaGlph	.QhDssLscPLDh-APPTIhsssLcPEhuoAALNLsuDal+QpQulsNKalhaHPlslsllslslhlals.+l...shPlp...o.s.Slst.hYplhhhNK+shlsullhohhssuhlFollut....loDsahppp.s.lstspuEplFGhsLpchs............................tpcpspcsh.............spNTcIIVYR-TPIAlISLssshs..lSoc.-shVhslTolGsR+VYlKSGIlEDLIDWAhl+o+slhpp...sK.......hupoh+LLlDlYSFDsshcchLcc+GFshlp.Shcls-.......................+LL..............GuLFGVp+-hWGlph..	0	3	14	25
+10957	PF11125	DUF2830		Protein of unknown function (DUF2830)	Pollington J, Finn RD	anon	PRODOM	Family	Several members in this viral family of proteins are annotated as lysis proteins.	25.00	25.00	46.90	46.40	17.40	15.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.76	0.72	-4.26	3	70	2009-01-15 18:05:59	2008-08-05 09:18:49	3	1	15	0	0	56	0	52.50	83	73.16	CHANGED	FKHEEYPCpcQQRSSTLYVLIsLAIFLSKFTNQLLtSLL-LLIRIVcTLQQLLT	.FKHEDYPCRRQQRSSTLYVLIFLAIFLSKFTNQLLLSLLEAVIRTVTTLQQLLT	0	0	0	0
+10958	PF11126	Phage_DsbA		Transcriptional regulator DsbA	Pollington J, Finn RD	anon	PRODOM	Family	DsbA is a double stranded binding protein found in bacteriophage T4 which is involved in transcriptional regulation. DsbA, along with other viral proteins, interacts with the host RNA polymerase core enzyme enabling initiation of transcription. DsbA acts as an enhancer protein of late genes in vitro. The protein consists of mainly alpha helices [1].	25.00	25.00	65.90	65.40	20.20	18.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.21	0.72	-3.89	7	36	2009-01-15 18:05:59	2008-08-05 09:23:25	3	1	35	0	0	26	10	68.50	52	76.26	CHANGED	hIpEASs.+hp.Euat-hlK-I+stAKpEhGl-GKhFNpLh+lYH+QpR-pFEsps-ElsplYDplFpt	.hIKEASDpKhplEuYs-hIKDI+p+AKcELGVDGKhFN+LlsLYHKpsR-pFEsEs-EllELYDslFs.t	0	0	0	0
+10959	PF11127	DUF2892		Protein of unknown function (DUF2892)	Mistry J, Coggill P	anon	Pfam-B_604 (release 23.0)	Family	This family is conserved in bacteria. The function is not known.	21.10	21.10	21.20	21.20	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.31	0.72	-4.14	172	1924	2009-01-15 18:05:59	2008-08-05 09:28:24	3	11	1526	0	602	1414	277	64.10	27	55.37	CHANGED	Mp...............NhGshDRhlRlllGlsllshshhsh.................thhhhhlGhs..hLhTulhuaCPhYtll.G...lsT.....sthp	.............................hpRhlpl.s.u..Gslll..huslh.uh..hst.......................hhhlsuhlGss..LlhsGloGaCsh...ttlL.p....h......p.h...........	0	191	418	532
+10960	PF11128	Nucleocap_ssRNA		Plant viral coat protein nucleocapsid	Mistry J, Coggill P	anon	Pfam-B_645 (release 23.0)	Family	This family of nucleocapsid proteins is from ssRNA negative-strand viruses of plant origin.	25.00	25.00	107.60	107.30	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.13	0.71	-4.80	5	129	2009-01-15 18:05:59	2008-08-05 09:33:54	3	1	10	0	0	80	0	178.00	68	65.42	CHANGED	RsLSKFIRETlF+-uDlcossLC-aLSSADPShFPASVFLKIsLDNLPTEVSSRCKMuIAGNKAIRYAlFApKF-.KDplusPTsussEslpEYlpKpEKLEKA+AIV-hLCSLuSNF-AQKKMHPLSPERoSRKNFTLQLTCAIVaSLSpcGRlDMRctI-ocKIEAFKRDENlYGctNu	.RKVPEFVKSKLY.DGDVSLSQISEELSHAPTKKFPARVFLKIDIDNLPSAVCSRCKLNIAGNRSVRYAGFASSFQTKQKLSPAVGATPESLMPLLETNQKIEKSIAIRDFLKTMEGQWKNQKRLHPLSDEKPTIKNFTLKLTCAIIYSLTPDGRIDMAERIITDKNKGFQNDRNFFGDGE.G..	0	0	0	0
+10961	PF11129	EIAV_Rev		Rev protein of equine infectious anaemia virus	Mistry J, Coggill P	anon	Pfam-B_124 (release 23.0)	Family	The sequence of this family is highly conserved and carries a nuclear export signal from residues 31-55, and RNA binding/nuclear localisation signals of RRDR at residue 76 and KRRRK at residue 159. Rev is an essential regulatory protein required for nucleocytoplasmic transport of incompletely spliced viral mRNAs that encode structural proteins. Rev has been shown to down-regulate the expression of viral late genes and alter sensitivity to Gag-specific cytotoxic-T-lymphocytes (CTL). Equine infectious anaemia virus (EIAV) exhibits a high rate of genetic variation in vivo, and results in a clinically variable disease in infected horses.	25.00	25.00	121.80	121.70	18.40	19.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.76	0.71	-4.17	2	322	2009-09-11 15:12:54	2008-08-05 09:34:35	3	2	4	0	0	217	0	132.90	91	96.22	CHANGED	PQtPL-sDpWCRlLRQSLPEEKIPSQTCIAR+pLGPGPsppssuRRDpWlRtQl.pAEsLQEpLEWRIRGVQQsAKEL-cVN+tIWRELpapccQ+GDauuassYpRtpEc+WGE.SSPRVL+PGDSKRRRKHL	.PQGPLESDQWCRVLRQSLPEEKIsSQTCIARRHLGPGPTQHTPSRRDRWIREQILQAEVLQERLEWRIRGVQQsAKELGEVNRGIWRELHFREDQRGDFSAWGsYQRAQER+WGEQSSPRVLRPGDSKRRRKHL.	0	0	0	0
+10962	PF11130	TraC_F_IV		F pilus assembly Type-IV secretion system for plasmid transfer	Mistry J, Coggill P	anon	Pfam-B_678 (release 23.0)	Family	This family of TraC proteins is conserved in Proteobacteria. TraC is a cytoplasmic, peripheral membrane protein and is one of the proteins encoded by the F transfer region of the conjugative plasmid that is required for the assembly of F pilin into the mature F pilus structure. F pili are filamentous appendages that help establish the physical contact between donor and recipient cells involved in the conjugation process [1].	21.80	21.80	21.80	22.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.23	0.70	-11.46	0.70	-4.93	71	713	2009-01-15 18:05:59	2008-08-05 09:37:15	3	7	493	0	136	633	29	242.30	22	29.40	CHANGED	stsphschLPa.....tpYsscsplal.....sspS..hGhhaElsPlsstscp......htctLpshlpp..sh..ssss..slQhhhhsssslsphlpp.hpshh...................ts............hhpphhtpphpaahcuht.p.t....sshsh......plRchRlhlhhphs.......tspsshpplpphpcpltusLpssGlt.spphsspslhsalhchh..NPpsshthss............Yst.p.................slspplhhssschcs.pp.shhhhs.....................t.scphlhshsl+phPct	......................................................s..sphschLPa.....hpY.......pp-..........splah.........sspo...hGhhh-hhPlsssscs......lh-slpphLps...chPcss....slQhhhh.s.s..s..plsshlcp.hhphhp.p................up................hhpchhttphtaahcuss.phth......pshsh........plRchRlhl.......hphs..............sthps.....pss...ht..phpplpcplp..u..uLtssulp.spphsupshhshltchh..N.sssthh.ptt..............phs..p..................slspQlh.ss.ch....cl.ct...shhhhs...............................t.spthlhshplpc.Pp...........................	0	28	67	108
+10963	PF11131	PhrC_PhrF		Rap-phr extracellular signalling	Pollington J, Finn RD	anon	PRODOM	Family	PhrC and PhrF stimulate ComA-dependent gene expression to different levels and are both required for full expression of genes activated by ComA, which activates the expression of genes involved in competence development and the production of several secreted products [1].	25.00	25.00	26.10	43.40	23.60	17.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.64	0.72	-4.38	4	36	2009-01-15 18:05:59	2008-08-05 09:44:28	3	1	21	\N	6	17	0	37.00	62	95.28	CHANGED	LKSKLhlhCLAhusVFsussl.ApAspppFcVApRGMh	.LKSKLFVICLAAAAIFTAAGl.AsA-tt-FHVsERGMT	0	2	2	2
+10964	PF11132	SplA		Transcriptional regulator protein (SplA)	Pollington J, Finn RD	anon	PRODOM	Family	The SplA protein functions in trans as a negative regulator of the level of splB-lacZ expression in the developing forespore [1].	25.00	25.00	29.20	29.10	21.70	20.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.57	0.72	-4.23	7	78	2009-01-15 18:05:59	2008-08-05 09:46:18	3	1	57	0	13	43	0	66.80	50	92.81	CHANGED	Mph....psapsGD.VYVIYRNPHstsVApIpEAtlVpHP.c.sELALFLaETYaPlspD.AlFso.-pAEphYpphFc	...............p.apsGD.VYlhYRNPHstsVApIppAElVsHPp+cGELALFLaETYHPLu--DAlauo.-EApphYp.hat......	0	3	7	9
+10965	PF11133	Phage_head_fibr		Head fiber protein	Pollington J, Finn RD	anon	PRODOM	Family	This head fiber protein is also refereed to as Gp8.5. Gp8.5 is a structural protein in phage. It is a dispensable head protein.	20.60	20.60	20.80	20.80	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.77	0.70	-5.20	3	66	2009-01-15 18:05:59	2008-08-05 09:51:36	3	3	62	1	12	64	7	123.30	22	66.00	CHANGED	MhsSFTAhANSsIlAY+LLsalEuE-pIEISaAcEcTIP-YVul+DLcsGDhTslshYPLAAWpVIAsSDIslG....D+lTTGKNGTlKhTcDspssFGYAVupApcGQLVTlI..IS+uFDplIpsDDlG-ssDsGphLhchssssGspshlI...DsKAhlpuNoTssNKKpLcD.LLlSsLsVKAF......LsusToD-NKANL............cpLhVSNPclLuhLsGsPSoEsKssLRoMIGAGsPYTLPAATTTTLGGVK+uAAVusSTATDVssuVKDFNuLLTALKNAGIIu	........................................................................................................................................................hs...................................................................................................................................................................................................................................................................................................................K..ph.st..........ss...uo.u.ssstshhtphNsllstL+suGhh................................................	0	3	7	8
+10966	PF11134	Phage_stabilise		Phage stabilisation protein	Pollington J, Finn RD	anon	PRODOM	Family	Members of this family are phage proteins that are probably involved with stabilising the condensed DNA within the capsid [1].	19.70	19.70	21.50	21.10	17.20	16.60	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.71	0.70	-5.92	3	145	2009-12-03 14:24:52	2008-08-05 10:02:23	3	2	137	0	6	107	10	449.10	82	97.02	CHANGED	hQLPLhKGLGKDhKsADYIDALPVNMLATPKEVLNASGYLRSFPGIsKKsDVsGVSRGVcYNT+pNAVYRVCGNpLYKG-KsVADlAGpGRVSMAHSRsSQAVsssGKlpLYRYDGTVKTLSNWPKDKtYTQYDLGsVRDlCRLRGRYlWsKDGoDpFGVTDLEDESHPDRYpAhYRAESQPDGIIGIDSWRDFIVCFGSSTIEYFSLTGAADsuuALYlAQPALMVQKGIAGTaCKTRauDuYAIISHQATGAPSVYLIGuGQAosIATATIEKIIRSYTADELAouVMETlRFDSHELLLIHLPRHVLCYDASASQNGsQWSLLKTGFYD-PYRAIDFMFtDNQITCGDKsEuLLGQLpFsuSuQYEpQQEHLLYTPLFKADNARlFDFELEASTGVAQIADRLFLSATTDGINYGREQMIEQNuPFsYDKRILWRRlGRVRKNIGFKlRVITKSPVTLSGCQIRME	...........................................QQLPLMKGVGKDFRNADYIDYLPVNMLATPKEILNSSGYLRSFPGIAKR.SDVNGVSRGVEYNMAQNAVYRVCGGKLYKGE....S.....E..V....GDVA..GSGRVSMAHGRTS...QAVGVNGQLVEYRYDGTVKTVSNWPs...DSGFTQYELGSVRDITRLRGRYAW.SKDGTDSWFITDLEDESHPDRYSAQYRAESQPDGIIG.IGTWRDFIVCFGSSTIEYFSLTGATTVGAALYVAQPSLMVQKGIAGTYCKTPFADSYAFISNPATGAPSVYIIGSGQVSPIASASIEKILRSYTADELADGVMESLRFDAHELLIIHLP..R..HVL..VYDASSSANGPQ..WCVLKTGL..YDDVYRAIDFlYEGNQITCGDKLESVTGKLQFDI..SSQYDKQQE.....HLLFTP.LFKADNA..R.sFD.LEVESSTGVAQY....AD.RLFLSATTD..GIN.YGREQMIEQNEPFVYDKRVLWKRVGRIRKNlGFKLRVITKSPVTLSGCQIRIE......................................................................................................	0	2	2	2
+10967	PF11135	DUF2888		Protein of unknown function (DUF2888)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins with unknown function are annotated as immediate early protein ICP-18 however this cannot be confirmed.	21.50	21.50	21.60	262.10	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.87	0.71	-4.48	2	13	2009-01-15 18:05:59	2008-08-05 10:27:34	3	1	13	0	0	11	0	143.20	81	92.36	CHANGED	GcPapppGshh.lPFupsFTIDLVNh.hpoEhpV+lpMoPphslGTFVVtPKphFSI+RAspGDAuFKVtRutGW.spT.QsLohhhYcR...l-hcsGs..pplETDG..GTVlVPGcsTGQRFupAhAh.hhFLap+.FllpGV	GEPYTCKGDLCEIPFuRNFTIDLVNLSVSTEFQV+ITMTPHHDLGTFVVEPKKVFSIKRAsKGDAAFKVtRAAGWLPDTPQVLoLFVYERLpPVEWHStChYENLETDG..GTVIVPGEATGQRFGTATAVPThFLFKRMFVVKGV	0	0	0	0
+10968	PF11136	DUF2889		Protein of unknown function (DUF2889)	Pollington J, Finn RD	anon	Pfam-B_001473 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.80	20.80	20.90	25.00	20.00	16.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.27	0.71	-3.89	49	270	2009-01-15 18:05:59	2008-08-06 10:06:50	3	2	200	0	113	274	147	120.40	34	54.07	CHANGED	HpRplphpuat+.p........DGLa-l.EuplpDsps.s.s........h.sspslHchplplTlD.sshpIhsspAphctsPas.hCspsssshppLlGhslu.Ga+cplpcpluGspGCTHLpELLt.slussAhQs	..................HpRtlphcuYtR..s........DGLa-l.EApLpDpKsh-hs..t...thh.sutslH-hhl+lTlD.pchslhcscA.shchsPas.pCssussuhptLlGlslt.tsaR+plpctLuGssGCTHLsELht.slsTsAhQs.........	0	25	62	89
+10969	PF11137	DUF2909		Protein of unknown function (DUF2909)	Mistry J, Coggill P	anon	Pfam-B_764 (release 23.0)	Family	This is a family of proteins conserved in Proteobacteria of unknown function.	28.30	28.30	28.40	32.20	27.00	28.20	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.07	0.72	-4.23	51	339	2009-01-15 18:05:59	2008-08-06 10:14:11	3	1	327	0	118	287	343	64.30	35	88.64	CHANGED	hKl.llllhllsIlsSLsSALaFLh+D...pu...........cupRhs+uLshRVuLSlsLhllllluhhhGhl....pP	...h+l.llllhhlhIlsSLsuALaahh+D..cG............popRhlpuLshRVuLSlsLhlhllhAhhhGhI......ss.....	0	22	62	92
+10970	PF11138	DUF2911		Protein of unknown function (DUF2911)	Pollington J, Finn RD	anon	Pfam-B_001491 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.90	20.90	21.80	23.40	19.60	18.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.90	0.71	-4.57	69	234	2009-01-15 18:05:59	2008-08-06 10:24:24	3	10	92	0	137	269	303	145.40	35	62.05	CHANGED	SPtspstt..........pl.uhsc......lplpYSRPuh.....+GRp..IF.......Gs...LVPYG...........cVWRTGANpsTplshscDltlsGcpltAGsYuLaTIPsccs.WslIhNp......sts.pWGs.........pYc..ppcDll.Rlplssp.phs..pshEphohshsshpsst.uhlpltW-pshVslsl	.......................SP.spspt......ph.uhsp...lplpYSRPuh......+GRp..IF.......Gs.....L..VPYG..............clWRTGANpuTplsFscDVpluGctltAGsYuLaoIPscsp..WslIh.Np.......shs.pW.Gs........hpYc..pspDllRlpVtsp.phs..p.hEsholsh...sshssst...upltltW-pstVslsh..........................	0	68	117	136
+10971	PF11139	DUF2910		Protein of unknown function (DUF2910)	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_001487 (release 23.0)	Family	Some members in this bacterial family annotate the proteins as cytochrome C biogenesis proteins however this cannot be confirmed. Currently no function for this family is known.	31.00	31.00	31.00	31.20	30.90	30.90	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.33	0.70	-5.20	46	566	2012-10-02 18:22:22	2008-08-06 10:24:54	3	2	322	0	120	408	26	215.20	21	94.89	CHANGED	lLshAlslulsPhplshslLlLpp.....s+PhhphlsFlsGhhlsshslsslhlhlhcsls......shpts.......sstthshlplllGssllhlushhhhpt..................................................tststhsphhsphp.....shs.stuhhhuhlhslhps.tshl.ahsAhuslsuuuhssssphsAllsFsllussslhlPLlualluspR..spshLtpl+sWhpsppphlluslhsslGhhllhp.Gls	....................................................llshAlshulsPhhlhs..s..l...l..h.....lpp.........scsh...p..h..hsFlsGhhlshsu..lshsslhhhsshs........shstt.........sphssshlp.lllGllLllhushhhtpp.................................................................................httsthsph..hpphp..........sht..sss.s.hh.huhlhsl.sps.tshh..hluAhshIsuushshssphhshlhFsh.l.shss.shlP.llual..ht..sp+....h..pthhtthp..sW..hp..p..p.pth...hh.shlhhhlGhhhlhpul.........................................	0	35	83	107
+10972	PF11140	DUF2913		Protein of unknown function (DUF2913)	Pollington J, Finn RD	anon	Pfam-B_001499 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.	20.40	20.40	20.80	20.50	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.19	0.70	-5.03	24	383	2009-01-15 18:05:59	2008-08-06 10:47:32	3	1	273	0	51	246	3	190.00	28	91.67	CHANGED	sYsptlhclspsuLspLptpp.psupshpsssscsHaLspWlspALKppRFs+hluc..sLptW.+puRShGssApLctlhp+Ipt.Yt....sstp.tpshstsplcuhLsplcptsWhVtT....-p.lss..KlplpoDGpsSLl.lsupphpppFss..spLlKPlohalRG...scpthhptAhppGhhlaphschpShVKaHt-YhlaPtNptstLspL..s	..........hp..lppll.sALstLpttp.cst.p.t.h.s.u.stpscaLlcWlspAlKpp+Fp+hlsc..cLpthhctu.Rsh..ust..upLtshhph..........sspp.tt.hshhclcuhLsphcptsW..p..lts......sp..lsp....plphh.ssGpss.Lh.lptsph-psFss.....schlpPlshhlpu...ph.t.thhpthhtsu.hh.p..c.t..lhhthph.h..tt.......l...........................	0	3	12	32
+10973	PF11141	DUF2914		Protein of unknown function (DUF2914)	Pollington J, Finn RD	anon	Pfam-B_001640 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.70	20.70	20.70	21.90	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.48	0.72	-4.45	39	174	2009-01-15 18:05:59	2008-08-06 10:47:56	3	2	158	0	77	178	90	68.50	36	22.50	CHANGED	pu..pt.lhHhWh......pssc.ssclsLslp.GsR...aRsaSpKphh..stsGcWcVcVhspsGpllushcFpls	..................ppplhHlWh..........tsGcphs+Is...LsIp.GuR...uYRsWopKpshs...sssGc.WpVcVloE..s..Gp.hIuslcFpV....	0	29	52	69
+10974	PF11142	DUF2917		Protein of unknown function (DUF2917)	Pollington J, Finn RD	anon	Pfam-B_001647 (release 23.0)	Family	This bacterial family of proteins appears to be restricted to Proteobacteria.	25.00	25.00	25.10	25.00	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.97	0.72	-4.78	40	253	2009-01-15 18:05:59	2008-08-06 10:49:20	3	3	129	0	98	236	21	65.20	30	55.56	CHANGED	tapLs.sGpshsh+stpssp.LpVt..sG...plWl...Tt.-u.......s.....spDaWLpsGpoLpLtpGp+lhluut...hssu	..................atls.stpshsh+..ssp.ssp...LpVp...sG..........tlWl...Tp.ss........c.....scDaaLpsGpslcltcGp+..lhlout..h...ss...............	0	9	40	68
+10975	PF11143	DUF2919		Protein of unknown function (DUF2919)	Polllington J, Finn RD	anon	Pfam-B_001684 (release 23.0)	Family	This bacterial family of proteins has no known function. Some members are annotated as YfeZ however this cannot be confirmed.	22.70	22.70	23.00	23.60	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.71	0.71	-4.37	29	662	2009-01-15 18:05:59	2008-08-06 11:06:50	3	1	644	0	64	283	15	137.30	54	96.12	CHANGED	as.ls.aDc+GplKsPlhhahsLlaLARuWslFlhusssRpstssLLplFYP-+ssFaluLssGlsAlLhh.llhucRp....ct.phlt..laphh+hhLlhslllphshhhhtlhhpthhashshulphllhhWhhlYLhpS++Lpthhpshpp	..............at...pYDspGhL+hPhhhWh..sLLh.ARsWVLF.VIAGuS.REQGosLLNLFYPDHDNFWLGLlPGlPAVLAF.LLSGRRs....shPp......lW+hLh.hLLLLAQlV.LCWpPa.lWLsG....-....uVoGlGLALllADIVALIWLLTNRRLRACFst...c....................	0	6	16	41
+10976	PF11144	DUF2920		Protein of unknown function (DUF2920)	Pollington J, Finn RD	anon	Pfam-B_001778 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.70	24.70	24.70	24.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.35	0.70	-5.45	20	738	2012-10-03 11:45:05	2008-08-06 11:26:01	3	2	129	0	22	553	3	187.50	29	98.00	CHANGED	NpTapIDSCDDVELsIKR..pSKLEaRloYDDpK-IKAIVhIIsGhGuDss.sahcahpcalA+pacVsslsVsYHChssR....sphuAphhh-c.DhhllcssLcslsl....shtslss.cphpphhphLspplpphKppshlspsapLp.LSsohhPscsEYQNFGIMtAlDllNAlhalh+c..........hsphus......lPpIhsGuSYGGYLApLsAKIAPWhlDuVlDNSuhAh...shhchI.hG+El-a.ph.ptush...hp..slplthasKTaWTp.scsSsaaFussphhIRslLNpcHLpIQupa..pshYloYHShpDphs.Psc-KpphachLcpLGFDssLplIpcEspIDG+FIKsL-HGhGlohKtLh+KcLPhlLEKl.shpsch..pc.cpISYPCc-hlYpFc-pscKlpLcI	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	10	14	19
+10977	PF11145	DUF2921		Protein of unknown function (DUF2921)	Pollington J, Finn RD	anon	Pfam-B_001920 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	18.80	18.80	19.30	18.90	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	909	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.63	0.70	-13.66	0.70	-6.83	7	137	2009-01-15 18:05:59	2008-08-06 11:43:06	3	5	21	0	96	115	0	572.50	24	90.89	CHANGED	Y......pp+Cps..stus.h...s.sststhhuppl.h.pssah..uGssslhshssspsh...........+.soFssppl.....t+s+sst.hlpVsuhLsLt....uspsshhshsht.pp.ph.hlst.........ph.hpGhYoE............upt.LCMVGsu...................sshus-ssslhh.tshlLhLphPKs.oLssphVpGpLcSssthsp...F-slpLluh.pp..pY.a.....pLs.tt..C.....cPhs.t.cthh.tupusps..h.tthCclLcch..t...shpl..shc.Csuoc.hsshhsshph............tshthhhpsl+Cps.t.......sss+s.lsFpshos.Eph..hs...t.t....ptoLsAEGhWcsosupLChsAC.lup.s.....sthhsts.CphRlSLpFPssaSIRsRShllGplhssss......sptshuFcplh.s.....pshppph.phh.h+YsYTcl-cAtchhtps.c.ush.....++...spaPts.t..........ShSDht.choh+hsut........upu.........sshslGshhhp....h..hutsphsshss.h....scshslpppp..LLNVShcIoh.................ossh.hppstlShEGlYDpcsGphhhlGCRcl.ph..p...s......tsuhDCpI.lplpasslsu+..spsph+spIpSpR.tcsD.LaFcthclpspshhh....c.ph.-sl.RhslEslhsllohThShshhshQLhah+pps.-shPhlSlsMLsl.ALGahhPLlhshEALFh....stppp.h...........hptsthhps.-hhl+llTllsFLLpLRLhQhVWpuRtps.pppstc.t..su-++sLhlsLslYlhGhlluhhlphstsph.hstt.ps..............u.p.tshhp-ltpYsGLhhDhFLLPQlIhNuh.pscs+.PLushFYhGsThlRhhPHsYDhhRupshsshhp..ssahaAssph....DaaupAhDVllPlsAhhLAhllFlQQRashthlh.t	...................................................................................................................................................................................................................................................................................................................................................h.s.h.s............................ta.a..............t...............................................C....h.......................................................................................................................................h..s-G.ap...ts.h.h.uC..h..................t.Ct.thph.h....hohptts..hG.h.s.t...............h..........................YpY..o.hp.stt.h.t......t......t......aP..................h...h..t.......................................h..l...h..................................................................hth..sh.h......................................h.hEGha....G.h.hluC..h...................t.DC.l...l.hths..t.........h..h.ItS.R..t.sD..hh...hth....h............................t..t.h.+...h-.hh.hh..sh.hhh.h.Qlhahpt.s..p..s...hSlhhhhh.shGh.h.Lhh.s.t.hhh........................................t........p.hh+h.hhhthhh.hplh.hsht.+.......t.......................sc.t.shhh...hahhhhhhhh..p........................................h.tahGlh.DhFLlPQllhNh.h.....t..p.p..slt..aYhGhThhRhhP+hYchhp........................s.t.....shash..hhDlhlshhsh.huhhlahQQphs.......p..................................................	1	4	55	82
+10978	PF11146	DUF2905		Protein of unknown function (DUF2905)	Mistry J, Coggill P	anon	Pfam-B_542 (release 23.0)	Family	This is a family of bacterial proteins conserved of unknown function.	22.20	22.20	23.90	23.90	21.70	20.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.18	0.72	-4.03	79	498	2009-01-15 18:05:59	2008-08-06 11:50:21	3	1	488	0	217	396	105	63.30	39	91.19	CHANGED	hu+hLlhhGll.llllGhlh....hl.t+.....hs.l..GRLPGDIhlcctshsaYFPlsTsIllSllLSllhhlh	........hs+hLlshGll.LlllGlhh....al.t+..........hs..h...GRLPGDIhlc.+s..NhsFYFPlsTslllSllLSl..lhhlh....	0	80	152	189
+10980	PF11148	DUF2922		Protein of unknown function (DUF2922)	Pollington J, Finn RD	anon	Pfam-B_001999 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.70	22.70	22.80	23.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.89	0.72	-4.32	49	773	2009-01-15 18:05:59	2008-08-06 11:52:37	3	1	650	0	145	467	0	68.00	28	90.76	CHANGED	KpLpLsFpsssG...Kphslslsssp-slotsplcssMspllspslFtssuG.sL.sshpuA+lV-psssslh.	.........KsLcLsFpssts....Kssplplspspss......lT....pp.lcssMssllstslhpss....s.u.sl..sphpuApll-+ssosl...................................	0	71	119	135
+10981	PF11149	DUF2924		Protein of unknown function (DUF2924)	Pollington J, Finn RD	anon	Pfam-B_002010 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.80	21.80	22.00	24.10	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.59	0.71	-4.15	31	178	2009-01-15 18:05:59	2008-08-06 12:38:05	3	5	96	0	88	183	81	132.10	37	82.95	CHANGED	lhs....clAtLsshshscL+thWpclas.stssphs+saLppRLAYRlQEhsaG....GLsppscp+L-plucptp.tphht......................ppsspphssGTpLlREWpGhpHpVtVhsDG.F-apG+pa+SLSAlA+tITGTRWsGPtFFGL+	..........................................................................................h..tplAtLtshshscLpthWpclas.ptssp.hs+paLpp+lAYRlQEhshG....GLstpspp+Lctlucphsttthht..............................ttsstt.hsGThLlREWpGppHpVhVhs-G.F-apG+hacSLSAlA+tITGT+WsG.hFFGL+...............	0	43	68	79
+10982	PF11150	DUF2927		Protein of unknown function (DUF2927)	Mistry J, Coggill P	anon	Pfam-B_739 (release 23.0)	Family	This family is conserved in Proteobacteria.  Several members are described as being putative lipoproteins, but otherwise the function is not known.	20.40	20.40	20.90	21.30	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.15	0.70	-4.65	65	243	2009-01-15 18:05:59	2008-08-06 12:55:41	3	1	191	0	58	212	104	206.30	34	67.68	CHANGED	sssplscsFhclAhttEYsps............hstlpRacsPl+ltlp...usssuspstDhstl...lsRL...uclsGhsI.shsss..........pANlplhhssccc.......l........pchlPpsustsls.h.shsctthChststsshsp.hptspsllhl.s-psshhhtsClHEElAQuLGLhNDo.clhsSlFNDD.s.aulLTsaD.lLL+hLYcPcL+sGMohs-ltshL.tl	.........................................................................................................s.ss.ltcsFhplAhpsEYstu...........tphlp+Wc..tP.lRlhhc...........ttssc+shctphltsalp+L...uplTGhsI.phsss...........pANlhllhsppsc...ht.tl............................cchhspsustsh........csshChsshps.s.s.s.s.phstuplllsVcpspsct.chluClhEElsQslGLsND..Stp...s...hPSIFNDc....s.pslLoshDhlLL+lLY-PcLcsGMotsplpslLp..h....	1	11	31	45
+10983	PF11151	DUF2929		Protein of unknown function (DUF2929)	Pollington J, Finn RD	anon	Pfam-B_002101 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	21.90	21.90	22.90	22.30	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.78	0.72	-3.89	28	624	2009-01-15 18:05:59	2008-08-06 12:57:35	3	1	618	0	61	231	0	57.20	33	90.30	CHANGED	M+Y....llshFWohlLsphlsalluuLsus.sas...hhsssIluVlhulllhllss.llstcss	.........M+a....llohhWuhlLsphlsalluSLsGG..oas.........hsps.hIhuVlhsllhhllus.slsspp.s.........	0	14	33	49
+10984	PF11152	DUF2930		Protein of unknown function (DUF2930)	Pollingtin J, Finn RD	anon	Pfam-B_002135 (release 23.0)	Family	This family of proteins has no known function.	23.10	23.10	23.40	23.20	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.10	0.71	-5.15	30	160	2012-10-02 14:34:25	2008-08-06 13:06:36	3	4	101	0	74	152	122	170.80	32	78.48	CHANGED	lsLhsGsLshsLhllNp.lss....ssloPu.pRA-VLuslhussLlLlulLWpphpP+.ss-tVsLpG..cpGhtlsssLspul+pELAWuSchLLTsTsssolLlaa.cGplLLRRGll............sss....phpPGsIspRshcppp........sl.LVNhtLYPGRs....EF-...hlPsNh.uVllQPLGsc...........GhlllGuhosRsFo+pDEpWlsGhA-KLc	...............................................LPlhsGshshhhlLlN+..lss..........sphos.uQsRu-lLulhLuss.lLsullWp.plp..........P+.u.......s....ssVsL.G........ppsh.hsssl..sp..shppELAWuo.hLLpsT.sstulllhh..ps..phllphGhh......................s...........phh.sthhppshpp.tt..................Lssh.haP...u+.........Eht........hlP.sh.ull.hQ..Plspp............Ghllluups.RuaoppDctWltshupKl...........................................................	0	20	50	66
+10985	PF11153	DUF2931		Protein of unknown function (DUF2931)	Pollington J, Finn RD	anon	Pfam-B_002146 (release 23.0)	Family	Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently, there is no known function.	22.20	22.20	23.10	23.70	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.28	0.70	-5.00	30	307	2009-01-15 18:05:59	2008-08-06 13:16:21	3	2	183	0	64	250	1	193.90	24	84.36	CHANGED	hphlhhll.hsL...lsuCssssh...............p.hpWphusshPpthsshVspsthhstscps..h.ts.sshs.....pp.ttt..tWsst........t..suh.sscspslPchlhlpWhSlh-pKtYppplpl..PcslpppMtpstphpspts.h......hRsslllGLAPGGhVpVWLps...tstsslhls+hpApplsss..phh.......phshshsph......pcpppsalcpcslPhG	......................................................hh...hh...h.uCtt.......................tW.hsh.hhPphhP.s.VThshh..hsspt.h....h.p...s.......p..tt...hspasth.............t...hstspphPpplhhhW.sSlhDpKhYpTchtl..sps.ltphhhs......hshsptss.hh............ahsphlhGLsPsGplpVWLps....stpslhl.s.pht.......pplpscc.shsK........t.p.h.h..............tthtshlc.cshPhs................................................	0	9	34	45
+10986	PF11154	DUF2934		Protein of unknown function (DUF2934)	Pollington J, Finn RD	anon	Pfam-B_002301 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.80	19.80	20.50	20.20	19.60	18.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.88	0.72	-4.59	64	414	2009-01-15 18:05:59	2008-08-06 13:46:20	3	11	258	0	181	424	25	39.60	35	34.70	CHANGED	tpp.p-cpIRcRAYplWEpcGpP.pGpspcaWhpAEpplpup	..........ttcccpIRctAYplWE.pcGpP..pGc..sp..caWhpAcpplct......	0	44	82	116
+10987	PF11155	DUF2935		Domain of unknown function (DUF2935)	Pollington J, Finn RD	anon	Pfam-B_002056 (release 23.0)	Domain	This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	21.20	21.20	21.60	21.20	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.68	0.71	-4.03	73	699	2009-10-15 12:33:13	2008-08-06 13:51:02	3	4	223	52	132	510	4	123.20	30	85.59	CHANGED	hhppslcpchFWhcIhtEHuhFIpssLsspE....pcllppAcpFtpp.F-pLhtcuhphssth.............................................................tlpplspcshp.tspplpsFKpplhcthlss+l.hshhhPLhhDHhlREupaYlphLpp	..............................................................ptlppphFWh+lht-HuhFlptsLcspE..........pcLlcpAppFtpp.F-.plhtpuhphps.h.................................................................tlpph.spcspt.tspplppFKpplhphh.lps+l...tshhhPhhsDHhhREsphalphLp.h....................................	1	53	112	117
+10989	PF11157	DUF2937		Protein of unknown function (DUF2937)	Pollington J, Finn RD	anon	Pfam-B_002314 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.30	25.30	44.30	30.20	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.92	36	166	2009-01-15 18:05:59	2008-08-06 14:10:53	3	1	162	0	56	163	20	162.70	29	95.05	CHANGED	hlhchLclhhhs....sGslhusQhPtFsppYtQRLsuplpEhppslssFptsAppa.ssshpphltpappss-.hhpscupshpphhsRhptLppshpth..pus.ap+hhhhhphschclhppThpsap.ulsLospulsaulssullhs.hlhthhhtlhthhht...+pppp	....MltphlcLllFs....hGhlhulQlPtFhspYtQRlsutl.EsppslpuaptoAppahtsshpthlp+apsssDsshpscupshpphhpRhphLppphtsh..pushat+shahhpsschclhppThssap.tl.Lss-ulsaGllsuLlls.hlhchhhhlhshhhp..tt.............	0	12	28	39
+10990	PF11158	DUF2938		Protein of unknown function (DUF2938)	Pollington J, Finn RD	anon	Pfam-B_002317 (release 23.0)	Family	This bacterial family of proteins has no known function. Some members are thought to be membrane proteins however this cannot be confirmed.	23.00	23.00	23.10	23.10	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.96	0.71	-4.87	36	258	2009-01-15 18:05:59	2008-08-06 14:19:11	3	1	249	0	69	220	189	145.00	41	88.88	CHANGED	lhIGlGATllMDLWullh++lhGlsshsaAhVGRWlsHhh+G+hhHpsIupussV..tuEphlGWhsHYhlGlhFAslLlslhG.sWltpPTlhPAlhhGllTVssPahlhQPuhGhGhAAS+TPpPhpsRlpS.....LlsHslFGLGLYluAhhl	...................................lhlGlGATllMDlWuhl...hphh.Gh..sshsauhVGRWhh.al.h+Gp....lhHs..sIupusPh....ttEhslGWhuHYulGllauhlhhhls.Gss...WhspPshhPAll.hGl.l.T.lsAsaFlhQPuhGhGhAAS+sPpPsts.R..lho......LluHssFGlGLYhsAhh.h...................	0	16	37	50
+10991	PF11159	DUF2939		Protein of unknown function (DUF2939)	Pollington J, Finn RD	anon	Pfam-B_002321 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.50	21.50	21.70	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.87	0.72	-3.81	35	245	2009-01-15 18:05:59	2008-08-06 14:27:23	3	2	210	0	84	227	37	94.70	26	44.55	CHANGED	slsshsshhhuSPYl....ulaplcsAlcspDstsluphlDaPuLRpSL+sQlssthhpph....ssphtssshusLuthhus.ullssh....VDshlTPpGltslh	.....................lhssh.hhh..hu...oPah.......sLtplppAlcs+Ds....sslspaVDaPu.lRtSL.+...pQlsstlhpph.....ssphpsssh....s.tlut.hlus.....slsssh.......VDshlTPpulsth.........................................	0	24	48	66
+10992	PF11160	DUF2945		Protein of unknown function (DUF2945)	Pollington J, Finn RD	anon	Pfam-B_002448 (release 23.0)	Family	This family of proteins has no known function.	20.60	20.60	20.60	20.70	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.68	0.72	-4.15	31	280	2009-01-15 18:05:59	2008-08-06 14:57:41	3	4	259	0	131	297	20	61.40	36	61.29	CHANGED	GD+VpW......sScsGcspGplhchpTc-schpG..+phcASp--PQYclcSDKTs+hAsHKssuLp+h	..........GDcVpW.............sSpsGpspGplhc....h....h..T..c..cs....c..h..p..G..+..s.....h..c..ASpD-PpYp...lcS-+os+.AsH+spsLpc.h...............	0	35	77	107
+10993	PF11161	DUF2944		Protein of unknown function (DUF2946)	Pollington J, Finn RD	anon	Pfam-B_002487 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	21.60	21.60	21.60	22.80	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.50	0.71	-4.62	41	142	2009-01-15 18:05:59	2008-08-06 15:05:40	3	1	141	0	58	133	19	185.90	47	96.43	CHANGED	MD-IV+pAlAKWPNVPsCaGWLuLDtRGpWhhRD-t.sQ.....ttG............h.Gs.lpHssLlsFIsRNYpsDtcGpWFFQNGPQRVYVEL-hTPalhRlps......t.s........hslpsHTGt..sht.spusalDEpGplhLs...................sshtluLlHD+Dlshhustsp...t...s................................ttplslps.ltpu-lstRFGFVtsPtst	...............MDDIV+QAlAKWPNVPpChGWLhLDcRGpWRhRD-tAQ.....AsG.............t.GsPlRHsuLlsFIsRNYppDtcGpWFFQNGPQRVYVELshTPWllRLsst......ss.......................huLssHTGt..sh..p.sstsaLD-tGsllhs...................ss.plAhLHD+DLshhuctscht.t....ut.s........hhth.s........................stshsl.psltps-VstRFGFVssPAtt...................................	1	7	30	46
+10994	PF11162	DUF2946		Protein of unknown function (DUF2946)	Pollington J, Finn RD	anon	Pfam-B_002520 (release 23.0)	Family	This family of proteins has no known function.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.01	0.71	-3.91	87	687	2009-01-15 18:05:59	2008-08-06 15:45:01	3	3	389	0	224	685	20	122.20	19	86.11	CHANGED	suW....lul..hAl...Lhthl.APhlupuhh........thstssh...ssshCssssst....tsshstststptsss.t.................................sC...saCshhstss......sLssshsshhshhhthtths.......sshhtshsstthassups.RAPP	..................................................h..luh...hAl...l.h.h...hl...uPhlupshs..............................stssh......ttsh.C.ssssst.............tsshstsss.t.pts..st.t..t.tt.....................................sC...saCs..h.hst.s......sLs.ssh..ssh.h.s.hh.hhhst.hs.......sshhhshh..tt.hast.sps..RAPP.................................	0	35	85	163
+10995	PF11163	DUF2947		Protein of unknown function (DUF2947)	Pollington J, Finn RD	anon	Pfam-B_002524 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	26.30	25.80	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.96	0.71	-4.64	22	169	2009-01-15 18:05:59	2008-08-06 15:50:15	3	1	168	0	34	105	7	151.10	56	96.65	CHANGED	YlPL-pYpRKWIFsHpshPVss-DhApIKPhoptRAsplWpcaISspSscs-pFscsDWss+sssWhps...cWpuAWDS.--ssLP-tlhtalc.WpD-ssVYFCYEKYplIET+WsVFhRsWKNFLFaDDGPlLlG+K+pQAlhFppsGphpLGp	........YlPLDpYpRKWIFTHtSMPVP-tDLApIKPMsptRAAQhWKENISspSPDAERLSSpDWPtK..sssWst-..ssWhutWES.D.-.spLPEtlssals.WQDDVTVYFCYEKYNVlETKWuVFKRaWKNFLFY.D.DGPhLlGRRRKpALWFsocGpVKhG.........	0	5	12	25
+10996	PF11164	DUF2948		Protein of unknown function (DUF2948)	Pollington J, Finn RD	anon	Pfam-B_002527 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	25.00	25.00	47.70	47.50	23.70	22.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.48	0.71	-4.55	42	207	2009-01-15 18:05:59	2008-08-06 15:56:21	3	2	205	0	71	164	1063	138.90	46	92.73	CHANGED	L+LhAhDs-DLtVISAhlQDAVh.su-hpWctpp+RFuLllNRFcWEss........tptpssERVposLth-sVhsVpSpGlc+sctDt.VLuLLulsFcP....uEssuGplhLshAGsGslRL-VEslEspLpDlotsatusuc..PsH	.........LKLlALDtEDLpVlSAHlQDAVlcluDlpahscc+RFsLshNRFsWEcs.......................hcptshcRhpouLpFscV.ts+upGIs+p.spD.sVLSLLulcF.s....ups.....PuGslpLsFuus..u..AIRL-VEClEspLsDlGssWpstut..PcH..........	0	20	43	51
+10997	PF11165	DUF2949		Protein of unknown function (DUF2949)	Pollington J, Finn RD	anon	Pfam-B_002571 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	22.20	22.20	22.70	24.70	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.68	0.72	-3.79	37	156	2009-09-10 15:59:59	2008-08-06 16:07:02	3	1	70	0	69	147	81	57.80	39	82.18	CHANGED	ssspLlpFLpp-LuLspsulslul+........ptctppuPLPhlLWpYGLloLpQL-plhDWlpp	....h..ppLlpFLpp-LulsssulslAlR........ppp..tp.......us...LPMlLWQYGLloLpQL-plaDWL-.t..	1	10	50	67
+10998	PF11166	DUF2951		Protein of unknown function (DUF2951)	Pollington J, Finn RD	anon	Pfam-B_002585 (release 23.0)	Family	This family of proteins has no known function. It has a highly conserved sequence.	24.90	24.90	25.40	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.39	0.72	-4.14	6	299	2009-01-15 18:05:59	2008-08-06 16:12:50	3	1	192	0	5	56	0	95.60	72	98.34	CHANGED	ht.hpR..hEp-hRIpRLE-NDKphFsoL-cI+cGQ+sQEhVNpKhDhTLDuIpRERELDccsKEcNpKNI+DlKMWlLGLlGTIhuSLlIAlLRTlFGI	......FGFTKR..HEp-WRlpRLEENDKTMFpph-cIc-u.+TQEpl.pKLD+sh-p..lpR-...+E.DEKNKccNsKNIRDlKMWILGLIGTIhSTlVIALLRTlFGI........................	0	4	4	5
+10999	PF11167	DUF2953		Protein of unknown function (DUF2953)	Pollington J, Finn RD	anon	Pfam-B_002617 (release 23.0)	Family	This family of proteins has no known function.	21.70	21.70	22.30	22.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.47	0.72	-4.06	60	397	2009-01-15 18:05:59	2008-08-07 09:14:46	3	1	368	0	104	330	4	50.90	29	23.20	CHANGED	sphGhtDsAhTullhGhlaultuhlhshh........pp.plplpPsFpcphh.cs	.......hphGhsDAAhTGllsGhhaulhuhhhshl.phhph...ptsphplsPsFppphh.t.........	1	45	85	92
+11000	PF11168	DUF2955		Protein of unknown function (DUF2955)	Pollington J, Finn RD	anon	Pfam-B_002614 (release 23.0)	Family	Some members in this family of proteins with unknown function annotate the proteins as membrane protein. However, this cannot be confirmed.	21.90	21.90	21.90	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.72	0.71	-4.51	42	253	2012-10-02 19:04:43	2008-08-07 10:34:55	3	2	195	0	82	281	23	138.00	25	40.93	CHANGED	+sLRluhGssluhsluhhhuashuhhsslhshhlL.shssshshphhhplhhsslhssh.shllsshlppaPlhhslllulhhhhthhhhhcssthLhushhllsholl.thushs..sssh.sllhulhhuhllulhlshls	...............psLRIuhGssluhslsh.hhshshuhahslhPhhlL.uhssshshcshhphlhssslsslpssllsshhtpaPhlhs.l...llhh..ha..hapat..h..h..scs.shhLFGshs..lls..ho...lhltFu...o...as...ss..shpslhhu.hhusllulhlshlh.......................................	0	7	21	53
+11001	PF11169	DUF2956		Protein of unknown function (DUF2956)	Pollington J, Finn RD	anon	Pfam-B_002632 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	82.50	82.20	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.57	0.72	-4.07	27	155	2009-01-15 18:05:59	2008-08-07 11:07:38	3	1	154	0	34	105	7	105.30	60	91.04	CHANGED	SsETQpEAh+lAKuTQKPGQTKEQTKLIAQGIEKGIApYKKQQKsKuR-tDKt+Kpph+sKpp........sppppspp..hspsp.shLPWs...LLsLSWlGFhuYlhh	....SppTQQEAlKIAKATQ+PGQTKEQTKLIAQGIEKGIA.YKKQQKEKpRQADKhRKKslKAKppsspt.....ts--.s...sph.s.ssspsppupLsWl...LLsLSWlGFluYhh.h.	0	5	13	24
+11002	PF11170	DUF2957		Protein of unknown function (DUF2957)	Pollington J, Finn RD	anon	Pfam-B_002671 (release 23.0)	Family	Some members annotate the proteins to be putative lipoproteins however this cannot be confirmed. Currently no function is known for this family of proteins.	25.00	25.00	36.40	39.30	17.70	17.50	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.21	0.70	-5.83	12	197	2009-01-15 18:05:59	2008-08-07 11:20:59	3	2	60	0	48	160	10	358.20	48	79.41	CHANGED	TaQlpalESsVPposGoVsPTR...sG..hshoGohsp.Ts.LPTsc.NpCAFhLpsuo.........lDsscPshlFlGpGVsGGuIPGATIpFsGl.....lGlGslPspTFPaYPFIuFupTETDhoKlAGsYNtlGaH.lPSt..........satPsssshp.TLNADGS...Csst...ssuoCpsoGssas.+....ususssF.Sssh..tGp.shPohupsts.h......A+GlhIVGKLpstLVPllIRsGYApsssssh.....sssADDEsGIulLuPssAlAssSlpGtYIGssSshsYtsoslsGs......pushLDPh.sspssLsusaphDaoQss.sGslossshsus.sushTGplhFsGusauaL-..osusoP.Fslus	.TaQlpal-SPVPtoTGTVsPTR....AG..ssloGTlspt.Tu..LPTsc.NpCAFhLs..suS...........................ls.scPshlFlG.GVsGGuIPGATIQFsGl..........lslGpVPspoFsaYPFIGFospETDloKlAGsYNpLGYHpVPSt..........Naussulsup.TlNADGo...Cssosh.......suG....uCh....soG....ssas.p....ususssFpSpsh...tsQ....lhPohuphs..h....t.A+GhhIVGKLpsQLVPllIRTGsAN..s..sssssh....sssADDESGISlLuPtsAlAuGS.sGtYhGsDSsFcYpsTulsGu......puThlDPh.sspsuLssuhsLDYsQss.PGslTsspssuo...us..ss...TGphlFoGGlauaLD..ssssss.Folsh................................	0	4	8	22
+11003	PF11171	DUF2958		Protein of unknown function (DUF2958)	Pollington J, Finn RD	anon	Pfam-B_002712 (release 23.0)	Family	Some members are annotated as lipoproteins however this cannot be confirmed. This family of proteins has no known function.	20.30	20.30	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.44	0.71	-4.23	21	220	2009-01-15 18:05:59	2008-08-07 11:26:14	3	10	148	0	82	208	67	105.00	36	22.38	CHANGED	LlTsp.RspLLANGptp........pchDPhPVVKLFsPsusuTWLlTELD.tDGD.phFGLsDLGhGhPELGsVSLuELtul+GPhGLslERDLaFpuppsLSsYActActsGuIls	....................................................hs.t.+t.Lhtpstt..tt......thD.hPV.V+hFsP..ussTWLLsEhD..P.t.Ds..........D...tuFGLs..D.l..GhG..h.PELGhhuLsELtul+...s.hs...ls........lcRDlaFp...........sp+.l..a.t.u...t....s........................	1	9	48	70
+11004	PF11172	DUF2959		Protein of unknown function (DUF2959)	Pollington J, Finn RD	anon	Pfam-B_002747 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	31.50	31.50	36.30	36.00	31.10	30.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.31	0.71	-4.56	27	148	2009-01-15 18:05:59	2008-08-07 11:40:00	3	2	143	0	54	137	29	200.00	51	92.68	CHANGED	llhLoG..CQSAYYuAMEKVGlHKRDIhVDRV--A+-oQp-ApEpFpSALEpapullsa-GG-LEctYspLscpYEsSpsuAccVpsRIcpVE-VAcALF-EWppELcpYsssoLRcsSpp+LcpT+ppYppLlpuM++AEsKMpPVLssh+DpVLYLKHNLNApAIuuLpGEhsslps-lspLlp-MppuIsEuspFIpphp	.....................h.hhLoGCQ.S....A...YYuAME+.V.G.hHKRDI..hVDRVE-A+-SQp-AQcpFsSALEphpuLssaDGG-LEssYsplNDcYEsSppAAp-VpsRIsslEDVA-ALF-EWpsELstYosA.oLRRsScpKLccT+ppYppLlpuM++AEsKMsPVLssh+DNsLYLKHNLNApAIuuLpGEFsoLcpDIstLIppMNpuIsESscFIppL..........................	0	16	29	45
+11005	PF11173	DUF2960		Protein of unknown function (DUF2960)	Pollington J, Finn RD	anon	Pfam-B_002756 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	20.60	20.60	21.10	99.90	18.50	20.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.66	0.72	-3.68	20	165	2009-01-15 18:05:59	2008-08-07 11:57:25	3	1	165	0	35	76	9	78.50	62	89.53	CHANGED	MARpItYTaKspsKcIsFSY-caHslaEAVAAAEGIDLTsaLtMEpQlthsS.+uspAV+saRcscFt+hGFocIpal+-	MARTIlYTYKsQ-KsLsFSY-KHHNIaEAVAEAEGIDLT-FLKMEtQlEulS..DTKuVRNFRDNaF+KLGFupITLt....	1	5	12	24
+11006	PF11174	DUF2970		Protein of unknown function (DUF2970)	Mistry J, Coggill P	anon	Pfam-B_713 (release 23.0)	Family	This short family is conserved in Proteobacteria. The function is not known.	20.20	20.20	31.30	31.00	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.58	0.72	-4.38	68	334	2009-01-15 18:05:59	2008-08-07 12:00:31	3	1	266	0	122	275	95	55.70	35	81.05	CHANGED	hhpshpuVlhuhhGVpppps+p+Dhsphs...PlhhIlsGllhshlFlhsLlhlVphVl	....hhpsl+uVhhuFFGVp.pscs+ppDhsphs...PltlllsGllhsslFlssLlhlV+hVl...	1	19	56	89
+11007	PF11175	DUF2961		Protein of unknown function (DUF2961)	Pollington J, Finn RD	anon	Pfam-B_002770 (release 23.0)	Family	This family of proteins has no known function.	20.30	20.30	21.60	20.30	18.20	20.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.64	0.70	-5.05	37	285	2009-01-15 18:05:59	2008-08-07 12:01:15	3	5	193	0	83	254	31	241.70	34	57.17	CHANGED	hhRp.lllRhYWDspptPoVpsPlGDFFusGau......hsthsShslss..ssssu........hssYa.MPFp+pA+IplpNpsstshtthaaplsY.s.h....ttlsccssYFHApW....+cppsh.......................shspsashl-.lcG+GpYVGshl...ulps.............hpss.....WaG..EG-.+halDG-..phPolpGTGoEDYFsuuWs...........h.hppassPatGhshhppsssh.t.....................hhuhYRaHlhDPIhFpcsL+lTlp...........ctch.p....phpsDhuSsAYW...YQs	......................................................................................................hRc.lll+hYWDspppPoVpsPlGDFFssGau.............................tsphsSlslss.....sPstu..........hNsYa.MPFp+pA+IslpNppspsh..t....ha..apIs....Y..s.h.......plspc......shYFHApW+Rpp.s.....................................phtps.a.sllD...lcG....+GpYVGshl...ulps......................pph........WaG..EG-.+ha..lDG-.....phPolpGTGoEDYFsuuWs...............................hppassPahGhsh...hpppssh.t.....................hhuhYRaHl.DPlhFpcsL+lolp................csph......ptpsDhuSsAYWYp.................................................................	1	33	56	69
+11008	PF11176	DUF2962		Protein of unknown function (DUF2962)	Pollington J, Finn RD	anon	Pfam-B_002773 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	23.30	23.80	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.81	0.71	-4.65	31	261	2009-01-15 18:05:59	2008-08-08 09:11:59	3	6	220	1	177	255	0	150.00	30	79.84	CHANGED	KlpKplu....tthcslHPpSRKsppLsRsshR-cKlpptKttptc+ps..hhp+ltaFpctlpp......................pppsaohp-hpplIc...................palsRp..DsELcplcpc....RRtuRP.ssRpphLcpphctEpc-ac..sGa.lPDLocscslchL+p.W....s.Gshss..lsslKhl+lop	.........................ptht....tpppslHstSR+utpLpRtshRpc+hpch+p.t+t.t+pph.......hh......c.........+ltaFppplss......................pptshotp-hpplIp...................p.alpRh..cpEL-plchc.......+Rp...GR.....ssRcsllcpph-pEpppac..sGh.lPDlssspslchl+p.W.......s.Gshtt..lssl+hh+ls.t..................	1	51	86	131
+11009	PF11177	DUF2964		Protein of unknown function (DUF2964)	Pollington J, Finn RD	anon	Pfam-B_002804 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	20.80	20.80	20.90	21.70	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.97	0.72	-4.04	8	102	2009-01-15 18:05:59	2008-08-08 10:27:27	3	1	52	0	27	87	3	59.70	48	91.07	CHANGED	MlRtchRlVLATlAVFIALAGlssslHGlLFD.ssshhYGlluLllGlAuFVlhLNPsPsDc	......MlR.phRlVLAsIAlFlsLAGhhsAl+GLLFDtsssltYGshAlslGVssFVlhLNstspD......	2	2	4	9
+11010	PF11178	DUF2963		Protein of unknown function (DUF2963)	Pollington J, Finn RD	anon	Pfam-B_002790 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Mollicutes.	21.70	21.70	22.40	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.96	0.72	-4.54	42	215	2009-01-15 18:05:59	2008-08-08 10:44:50	3	8	18	0	139	213	4	48.20	33	56.38	CHANGED	Yp..DGc.pIphI..p....EYsspTGphIKcThY.p.DGcsIphIp..EYs..pssphIKpT............h	...............................a..cGp..pIphI..p........Eassp.TuchIKpThY.p.D.G.p.sIp.Ip..-as...ptp.h.p.....................	0	33	35	98
+11011	PF11179	DUF2967		Protein of unknown function (DUF2967)	Pollington J, Finn RD	anon	Pfam-B_002838 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Drosophila.	25.00	25.00	37.20	37.20	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.88	0.70	-4.89	2	40	2009-01-15 18:05:59	2008-08-08 11:05:57	3	2	15	0	8	40	0	242.90	79	53.62	CHANGED	PSTAPPPTRhREHFTFDPPQSPKSARoSEKupSHFoFK....EsAppAthuSsphhuuG...................AAoEusEtp-ER...uluNRsKKLRsRERDs...................N+ISPSVSPSpSpRsSPKRE++RTTP.sSTGAIuKlsSAPPTMKDuNFFGSStpQKQR.SQp.Ps...pQLSPSS....QQRKYSSSSSSGSS-RCLR-sTusGTMFPFDREALDYERIQRECFAPSSsTASsSSDS.EAENCSVYERK.uADIFQ	...................PSTAPPP.TRGREHFTFDPPQSPKSARTSEKARSHFTFK..........EDAQQARRASNSYY.AGG..........................................AAoEAAE.AQEER......AVANRNKKLRARERDSMAGNANANANANGGS.NSoRNRISPSVSP..SSSNRTSPKRERKRTT....PSVSTGAIAKINSAPPTMKDGNFFGSSQNQK.QRPS.QQ.QPSPQQQQLSPSSQA.AAQQRKYSSSSSSGSS-RCLRD.V...A.AAGTMFPFDREALDYERIQRECFAPSSA.TASTSSDSDEAENCSVYERKLSADIFQ...............	0	1	2	5
+11012	PF11180	DUF2968		Protein of unknown function (DUF2968)	Pollington J, Finn RD	anon	Pfam-B_002850 (release 23.0)	Family	This family of proteins has no known function.	27.00	27.00	27.40	79.90	25.60	25.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.24	0.71	-4.92	12	142	2009-09-11 05:56:16	2008-08-08 11:12:26	3	1	95	0	44	135	4	192.10	43	81.57	CHANGED	pPsst.......sstsssss.ssAsutuu.....spusVsELpphlpsppLoELRTTYNGuYGASLLFpsc-hTYYVALFQpKsFWRVIKTsshspAEtlY+sFucQospLA-lElRRspLpAQKA.hER.lAhupsRAppLQADlpltppQcttVsscQpQsRpEsssLptp+ppspsQLcphQRQlctLQtptpp...ulP	.....................s..........t.ssssss..ssAsusus.........upusVsELQphlpu+cLoEhRTTYNGoYGASLLFssp-hTYYVALFQpKsFWRVIKTtscs+AEtlYcsFucQotpLAssElc+scLEuQKAhh-RtIAhsppRAppLQADLslsRpQpAtVusRQcsspsEssALpsp+pttQsQLRpLQpQlRpLQ+Qsps......s...........	0	4	14	28
+11013	PF11181	YflT		Heat induced stress protein YflT	Pollington J, Finn RD	anon	PRODOM	Family	YflT is a heat induced protein.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.90	0.72	-3.87	12	479	2009-01-15 18:05:59	2008-08-08 11:33:15	3	3	229	0	85	298	1	95.40	28	57.40	CHANGED	.hlctapNppclhpslppLptpGhspcDIYVluHDc-Roccls-sT.....csssluhcE.pGhhsslhshFp.cpGDELRs+hpclGlocsEAcpaEccLDcGKlllhV	.......hVt.apscpEshpslpcLpp..cGhppc-I.hVlo.+....-...c.......cch........-cl.t.-so................ssN.....s.h.sscc...pulhsphhshF......p........tpt...D...p.....c.sth.....pp....hs..hscpEhp.YcpclppG.+hllh.......................	0	28	65	76
+11014	PF11182	AlgF		Alginate O-acetyl transferase AlgF 	Pollington J, Finn RD	anon	PRODOM	Family	AlgF is essential for the addition of O-acetyl groups to alginate, an extracellular polysaccharide. The presence of O-acetyl groups plays an important role in the ability of the polymer to act as a virulence factor [1].	25.40	25.40	25.40	26.20	24.60	25.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.81	0.71	-4.60	13	100	2009-01-15 18:05:59	2008-08-08 11:43:13	3	5	83	0	31	89	3	173.80	41	71.82	CHANGED	slhLuluuhsAtA..u-ssLYsssAPpsSAFVRhhNuosuplslsl.GssshpslusspsusahahssGuts.....hplGupslsscl..suspahTlVspssu.....pshLlE-PshpscpKA.LthhNLoss..ssoL+TADGcs-VVcsVussupucRpINPVKlsLAlhsusppVushcsl.sLc+G-sho	.............u.huLulhuht....A.A..u-...uALYussAPcGSsFVRhhNAusup..lss.o..V.GssslppVushu.uosa..pFhPtGsYo.......splGups..l.PVcL...ss-cYYTlVspsuG......pspLlE-.P.s.FcN+pKuLlRV.NLosp..pLoLKTADGKT-VVcsVuspupGcR-I.NPVKVsLALasGs+KV..ucl+.sV.sLcRGEsh................................	0	4	12	24
+11015	PF11183	PmrD		Polymyxin resistance protein PmrD	Pollington J, Finn RD	anon	PRODOM	Family	PmrB forms a two-component system (TCS) with PmrA that allows Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin G [1]. The TCS is linked to another one via the polymyxin resistance protein PmrD. PmrD is the first protein identified to mediate the connectivity between the two TCSs.  It binds to the N terminal domain of the PmrA response regulator which prevents its dephosphorylation, thereby promoting the the transcription of genes involved in polymyxin resistance [2].	21.00	21.00	22.10	27.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.93	0.72	-4.17	3	441	2009-09-10 18:00:43	2008-08-08 11:46:37	3	1	427	2	10	87	0	79.60	76	92.99	CHANGED	MEWLVKKSpsNKpcu.CHVllLCDuGGALKMIAElcS.cltL+sGDlLSPLpDApYCINREKpQTLKIlsAoCYSsDEWpRtsK	MEW..LVKKSppsKpcs.pHVLMLCDAGGAIKMIAEVKS.DFAVKVGDLLSPLQNALYCINREKLHTVKVLSASsYSPDEWERQC+....	0	1	3	5
+11016	PF11184	DUF2969		Protein of unknown function (DUF2969)	Pollington J, Finn RD	anon	Pfam-B_002861 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Lactobacillales.	25.00	25.00	29.40	28.90	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.39	0.72	-3.89	19	584	2009-01-15 18:05:59	2008-08-08 11:53:44	3	2	582	0	56	191	0	74.00	46	97.69	CHANGED	MSKK-KcIElplp-tcs....ss.sshplhI.GK+hIGpItph.-pcF..sshpssssphhhKsh-pAlptllcpaNLp	....MS.KK-KcIEIplsDsKsplstcsh-ua..pLhI.GKKlIGEIs-l..DspF..AIlpsuss-uFaKpLEcAlEhlIcsYNLp........	0	10	25	40
+11017	PF11185	DUF2971		Protein of unknown function (DUF2971)	Pollington J, Finn RD	anon	Pfam-B_002776 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.80	21.80	21.80	21.80	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.31	0.72	-3.27	145	706	2009-01-15 18:05:59	2008-08-08 12:00:33	3	24	537	0	185	600	22	90.70	22	28.45	CHANGED	MWspYuss.t.....pGlslta.....................................................tttt............thhhtpVpYsspp..tht.hphhttt....................................................pthhhh.......KppsapaEpEhRl	........................hWu.tYuss.p..........pGhslta..........................................................................t..pt........................tthhh..t..p..V..p..Ypsp....pht..hhph.h..t..........................................................................................h.pthhhhKspsWpaEpEhRl................	0	76	122	149
+11018	PF11186	DUF2972		Protein of unknown function (DUF2972)	Pollington J, Finn RD	anon	Pfam-B_002895 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as sugar transferase proteins, however this cannot be confirmed.	21.90	21.90	23.40	23.30	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.51	0.71	-4.42	21	237	2009-01-15 18:05:59	2008-08-08 13:53:51	3	1	88	0	9	179	0	178.40	36	43.56	CHANGED	alDhpEIhsc+sFpThppLucta..pFs.Pp..s-cphappth.huch.hslLPlsLhlp................sshslhh...........s.h.h.......................hhphpcphhsIspplh....pps.hh-pl.......hlhlcpp-achlhp...spplhpplKpYLpcF...l.tLccplchccs+hlpEcDlLpYL..Kcp+plph+hKplLDcE.LsaIKppRPDIVsSWKYYQEFE+hCcELc	..YlDhp-IptppAapThphLuhpa..sFs.P....pp.phFp.p....hs.l..hhlh..PlpLhhsp................phpI.h...........p.l.l..s....................h.phppp.hlcIh.pplh.....pp.hhssh..hlhIcppcap.Lpp...sphLhppl+pYl.cF...l.tlcppls.pcpphh+EcDlLsYh..pcspslhhphppIh-pE.LpalKpp+PcIlsSWcYYpEFEchhpt....................	0	3	8	9
+11019	PF11187	DUF2974		Protein of unknown function (DUF2974)	Pollington J, Finn RD	anon	Pfam-B_002933 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.36	0.70	-4.98	24	1013	2012-10-03 11:45:05	2008-08-08 14:07:40	3	19	778	0	142	1032	52	195.30	27	47.94	CHANGED	hupSsRFpslcltsalsplstc..ppQFuAhsapls..........ssohhluFRGTDsollGWKEDFpMuap..lsAQctAhcYLpplhpphss........s.lhLsGHSKGGNLAhYAAhp.hpsslp.......................pRItclYoaDuPGh.cphhp..sstapplts+lpchlPpsSllGhhLEpspph....hlVpSss..ulhQHcsaoWpl.psspFlpt.cslsssSphhppslppWlsslst-pRcthh-sLFs	................................................................................h.....Ratthph.thhp.th.....p........p......tp...Q.Fu.A..h.s.a.pls........................s.s.h.hl.s.FRG.....T.D........s........o.....l...l......G.............W.....+..E.....D.h.....p...h.....s......a.h..t......p......h...s..u......Q........c.......p..A......h.....p.Y..L..c.p...h.h.t.p.a....ss...........................................p.lhlsGHSKGGNL.A.h.YAAsp....hp.tp.h.p...............................p.p..I..t....t.lasa........Du.P....Gh...p..p..h..hp.......p...t....h..p..t..h...h..t+.h.h.hl.Pp.tul.lGhhhp....t..............hl...V..p..S.....p......hh.....Q....H..hp.Wph....t......ttph..........t..s.....u...htt..h.th.tths.tpht.hht.ha.t.......................................................................................................................................................	0	35	74	101
+11020	PF11188	DUF2975		Protein of unknown function (DUF2975)	Pollington J, Finn RD, Bateman A	anon	Pfam-B_2875 & Pfam-B_3379 (release 23.0) & JH:B0MX27	Family	This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	26.10	26.10	26.10	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.65	0.71	-4.45	99	988	2009-01-15 18:05:59	2008-08-08 14:12:43	3	1	759	0	233	831	18	140.00	17	82.57	CHANGED	hhhsthhtth...........sphhsthshhhhshh.................................lh...shhsslshhhulhphh+Llpplpcs.psFot..pslctL+hIshshlshsllhhhshhhhhhh.st..t..................hhhhhhshsshhlu.llhhllpclhtpAl.......cl+pEpDLTI	...................................................................................................h................................h.hh....................................lh.....hhhssls...h...h..h...slh....ph.h+....Ll..ph.l..pc.......s..psFop..tslptl+plths..hl...s...hu....ll....h.h....lh....h....sh.h..h.hh.....ht........s...h................hhhhsh.h.s.shllu.lhh..hllp.c.lhppAl.......clcpEsDhTl......................	0	90	171	199
+11021	PF11189	DUF2973		Protein of unknown function (DUF2973)	Pollington J, Finn RD	anon	Pfam-B_002929 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently they have no known function.	22.20	22.20	22.30	30.30	20.10	21.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.18	0.72	-4.20	34	106	2009-01-15 18:05:59	2008-08-08 14:16:03	3	1	95	0	32	106	363	66.70	34	72.64	CHANGED	hhsLlYhhsFhhLhh.AapshhpGhhsssht...............p.p.tt......................s+ssphTsHPELLDpsGclscE-LLsVR	...........................hh.LlYhhAFsllhhlAhtshh+uhhsssht...............ppp..s......................sppsphssHPELLDcsGpllpEsLLslR.	0	4	18	29
+11022	PF11190	DUF2976		Protein of unknown function (DUF2976)	Pollington J, Finn RD	anon	Pfam-B_002963 (release 23.0)	Family	This family of proteins has no known function. Some members are annotated as membrane proteins however this cannot be confirmed.	26.10	26.10	29.80	40.90	25.30	25.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.89	0.72	-4.46	22	218	2009-01-15 18:05:59	2008-08-08 14:22:53	3	1	179	0	63	180	9	86.90	41	72.80	CHANGED	LPshpsPosG.......sGsshhpplpsYhhDGhhLlGLlluAhuFlsVuhsulpsasEl+s..GKtsWucFGshllVGllLllhslaLlscAssI	......LPshEsPopG.......sGsGlhpTlpsYuhDhlhLluLllsAsuFlsVuhpuluoYsEl+s..G+tsWupFGhslsVGslLlllsIWLlTcAssI......	0	6	27	50
+11023	PF11191	DUF2782		Protein of unknown function (DUF2782)	Gunasekaran P, Mistry J	anon	Pfam-B_001700 (release 23.0)	Family	This is a bacterial family of proteins whose function is unknown.	21.20	21.20	21.60	21.60	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.61	0.72	-4.06	41	297	2009-01-15 18:05:59	2008-08-08 14:24:31	3	2	290	0	102	233	41	111.00	24	91.26	CHANGED	p....llhss....hLussshAtsst.pss........ss..................p.-P.............-lsI..hpcss.pplpEYRlsGplhhlKVpPcsG...hsYaLlcs-Gp.upascpst....s.shhsPtW.............................plapW	..........................................................................h.....h....hhsh.s...usss......ps.s............s..................................cs..................-hhl......hp-ss..splpEYRlsGphaslcVpPtpG....tsYallcssus.ssascppt.....schhhstW...............................plapW...........................	1	20	64	87
+11024	PF11192	DUF2977		Protein of unknown function (DUF2977)	Pollington J, Finn RD	anon	Pfam-B_002980 (release 23.0)	Family	This family of proteins has no known function.	20.60	20.60	20.80	25.10	19.50	17.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.05	0.72	-4.14	7	236	2009-01-15 18:05:59	2008-08-08 14:27:35	3	2	170	0	4	81	0	61.20	58	49.41	CHANGED	MplhlN...........D+stIhGasshGuh-pu...l-lc.splPtpFpcpFcPctahh.su..pIlhNpsYhc.p.	.........MpIhVN...........c+NElIuYs.hGGhcpu...lDl-...NlP.pFpp.FcP+tFhaoNG......EIhaNpsapcEc.s.....	1	4	4	4
+11025	PF11193	DUF2812		Protein of unknown function (DUF2812)	Gunasekaran P, Mistry J	anon	Pfam-B_001697 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins, however some members of this family are annotated as membrane proteins.	22.10	22.10	22.20	22.30	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.43	0.71	-3.94	34	805	2009-01-15 18:05:59	2008-08-08 14:30:02	3	2	587	0	77	554	3	113.20	26	57.20	CHANGED	hsh-+.-EpaLpcMupcGatLpchshhh......YpFc+.scPpchhYclDap.........sppcpp-Yhphac-sGWchl.....sph..sphp.......................aFpcttsptt.....-IaoDppo+hpphpp.hhphhhhhhhhhl	............h.sh-+-EpaLccMth+GWphpp..h.phhh.........apFcp.sp.Pccs...h..Y+l-hp............p.ppchpcYhphac-pGWchl.......s.h....ushp................................ha+K....psssh......plao..-.pts+....hphh+p..hhp.h.hhhhhh...h.................................	0	35	59	69
+11027	PF11195	DUF2829		Protein of unknown function (DUF2829) 	Gunasekaran P, Mistry J	anon	Pfam-B_001848 (release 23.0)	Family	This is a uncharacterised family of proteins found in bacteria and bacteriphages.	25.00	25.00	25.10	27.30	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.81	0.72	-3.50	24	638	2009-09-11 11:01:00	2008-08-08 14:31:38	3	2	599	0	49	240	8	75.90	53	85.74	CHANGED	MsFpEAl..tlKpGcKhsRp.GWsGtphaltl...........................psssh..psalhlpss....psph....hs.WsPossDlLA-DWhlV	.............MTFEEILP.uL.KAt+KhVRs.GWuGsEpYVpL................................................hDsl.ctsGhsLp.hTPYFLIsso.........cGEG....FSMWuPTsCDVLAsDWl.V..	0	13	27	37
+11028	PF11196	DUF2834		Protein of unknown function (DUF2834)	Gunasekaran P, Mistry J	anon	Pfam-B_001850 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.90	21.90	22.50	23.10	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.33	0.72	-3.83	47	198	2009-01-15 18:05:59	2008-08-08 14:32:12	3	1	185	0	55	167	264	99.00	30	76.31	CHANGED	lYLhLAlhGslhPhht.ltal..tpsG.......h-ltshlss.hhuN.suupulshDLhluAlslslallsEu.+hph+thah...slhsohslulusGhPLaLaLRp+p	............................lYhllulhuh.slsahhslpal...pp.u............hshst.alph..hhsN.sAusu...huhDlhIuslslh.lahhs-uhR..hsl.+phWl.....hhluohhluhuhuhPhYLhhRER.....	0	14	32	46
+11029	PF11197	DUF2835		Protein of unknown function (DUF2835)	Gunasekaran P, Mistry J	anon	Pfam-B_001851 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins. One member of this family (Swiss:A4VM42) is annotated as the A subunit of Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV).	25.00	25.00	56.50	56.40	21.60	19.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.89	0.72	-4.20	42	218	2009-01-15 18:05:59	2008-08-08 14:34:21	3	1	218	0	59	150	18	64.60	43	91.10	CHANGED	hhFslslShpcals.aYpGtAppV.VhspsGcplplPApphRPFlTppGl+GpFclphspps+alsLp+	......hhhplslShpphls.aYpGhAspVhVpocpGh+lpLPAp+LRPFLop.GV+GpFRLshDpss+FlpLE...	0	15	31	47
+11030	PF11198	DUF2857		Protein of unknown function (DUF2857)	Gunasekaran P, Mistry J	anon	Pfam-B_001886 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	31.00	31.00	32.70	38.20	30.70	30.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.00	0.71	-4.76	32	266	2009-01-15 18:05:59	2008-08-08 14:35:22	3	2	219	0	73	222	8	177.30	33	90.10	CHANGED	sLNpAlLsphlpsL+pGp.lppCcshGhs.--lptLpphshpcl..LssusVshss....lslsp-sht+llppsccppp....cpphl-RhLcLGAShpMhppaFGL.ospEVutRRclL.ulstppGRhshhsE.ppcptlWctWpt..pptslt.h-ssphL-hhMhlAEphsl.............sLoslWshlppW.pps	........................lNpulLsphLhsL+sGp.l++CcshGhs.-ElshLppholpcl..Lu.susVshss....lsls+-sLp+lLspuccppp....c.ppl-RALcLGAShphhpca.FGL.ospEVutRRcll.Gls...h...+.pG.RpsshsE.-p-stlWcpWp.....ctslpt.DssphL-hhM.lAE....phsl.............sLosVWstlppW.pps......................	0	7	33	54
+11031	PF11199	DUF2891		Protein of unknown function (DUF2891)	Gunasekaran P, Mistry J	anon	Pfam-B_001921 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	45.90	45.60	22.40	21.90	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.14	0.70	-5.85	33	328	2009-01-15 18:05:59	2008-08-08 14:37:19	3	1	324	0	81	223	116	319.90	46	94.86	CHANGED	As+FApLsLssls+EYPNKlsHshsussDlp.sP+pLHPsFYGsaDWHSuVHGaWhLV+LL+pa...P-hspsspIpusl-cplTsEslAsElAYhppststu.FERPYGWAWLLpLstELppac.........sstupcWupsLpPLsphlspRhpsaLP+LsYPlRlGsHsNTAFALuLAhDaAcsstcpsLpphItppupcaahpDpssPstaEPuGcDFLSPsLtEAcLMRRVLs....sspFspWhctFLPplsstt.sphlpPusVoDRoDGKluHLDGLNLSRAWshculAsuLPps..ttstlpssApcHlsuulsplsut.cYhGsHWLuSFAlhA	......................ppaAplsLsslpREaPN+hsHphsussDlp.sP+tLHPhFYGsaDWHSSVHuaWhlV+LL+pa.....schspt..-pIhssLcsphTcEsstsEhtYLph....t..p.+........GFERPYGWuWhLtLuspls.hs..........stuppWApslpsluphhhcphhpaLP..KhoYPlRsGTH.NTAFALuLsLDaARt...hp...csp.lttsIlppA++aahsDts...h.u.........aEPuGs....-FLSPuLhEAcLMpRVls....ss-FssWhcsFLPpLspp-.s.sLhsPs....pV.....o..D+..oDGK...l.....A.HLDGLNLSR.AWsh+uLAshLsEs..t+.ttlcpAAscHlspulsplss..DYhGsHWLuSFALhA.........	0	24	50	66
+11032	PF11200	DUF2981		Protein of unknown function (DUF2981)	Pollington J, Finn RD	anon	Pfam-B_003040 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.00	21.00	23.30	23.20	20.20	18.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.15	0.70	-5.35	2	8	2009-01-15 18:05:59	2008-08-08 14:59:40	3	2	5	0	8	8	0	120.40	34	56.25	CHANGED	YLILFsFSLVVVSMVALDMAElVHFFPKAPELHshoLLGhTuPFVTRFKsPNASVLFPFNFFKLPNDTTGVLPQL.H...............................DphVVTKFThoplDpHsHKHCNKhsot....RFDDDlSuVLDNhDssDDLpsLRNALKQRLtspN.......TstssoGssD...NYNAYDNPDGKV.uuKDlNS.................spsSsNsssSsspKpptsDSFYDHLPFMPHPGETEGESEEVSKDEFPPETNDLTPEGKSEVVVLYKLQKRs.phhhS.....alhhhlY	................................................................................................................t...........................................................................................................................................................................................................................................................Y-clPFhPH.spTEGEoEElStsEhPPEspsLT.pt.pEVsslhKhQKR............................	0	4	6	7
+11033	PF11201	DUF2982		Protein of unknown function (DUF2982)	Pollington J, Finn RD	anon	Pfam-B_003059 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	25.70	38.90	19.50	17.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.78	0.71	-4.86	24	166	2009-01-15 18:05:59	2008-08-08 15:05:09	3	2	160	0	37	120	8	148.40	48	67.74	CHANGED	SlpLotptlpYaH+pGsWhlcWpNIpRlsls+hppshpphpLPaIGIKLKphsshLssIsPRLAotLLhEQRsLLhhusppcp.shpshEshLhs-tsalsspGppY+GllAMaupRhphLpchLGYclalstssLDRsspEFluLLRcaptts	.......................s.aTLTsoHlQ.HahpGGWVl+WsNIppIGlsphc.p-GWaQPLPWlGI+LKcYsPaLsuIsPRLuTpLLlpQRuLLhLuApQps..c...tpp.......aEDhllDspsYls.scGcpYpGL.AMLANRMpYpRcahGYDlFISpp-LDRsu-EFVGLhRRYLAAA.........	0	6	14	27
+11034	PF11202	PRTase_1	DUF2983;	Phosphoribosyl transferase (PRTase)	Anantharaman V, Pollington J, Finn RD	anon	Anantharaman V	Family	This PRTase family has a C terminal RNA binding Pelota domain [1]. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	31.70	31.70	37.40	37.30	26.20	25.20	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.58	0.70	-5.41	68	350	2012-10-10 14:25:38	2008-08-08 15:38:30	3	7	335	0	73	275	5	247.50	50	60.57	CHANGED	sl...p...........GSYtssDVpFLL+sl.s..hpp.sss--+EchIQSG.phHYSEMLshEhpPoptYhcLFcpALppsutRlAtsVuhlActlhp......c.ps.ssllLVSLARAGTPlGlLl+Rhlpp........Ghs.....ssHYuISIIRDRGIDpsALcaI..hp+Hs.spslVFVDGWTGKGAIopELpcAl.t.p.h.ppth.............s.......hss.cLsVLADPutCutlhuTc-DaLIPSuhLNuTVSGLlSRTVLssch.l.....ssssF...HGshaYccLtstDlSphFlDslssth	............................h..GSYtPsDVpFLLKsl.s..hp.sssEc+EclIQSGptHYS-MLs.E.tPoptahcLFccALcpsupRlAptVstLAptlhp.......c.ts...p..slVLVSLsRAGsPlGVLl++hl+t.........Ghs...s.HYuISIIRDRGIDtsALcaI..hp..+..H..s..spsIVFVDGWTGKGAIotELtcAL.phpsth.........................s.....hpscLsVLADPsuCuhLhuoc-DaLIPSuhLsusVSGLlSRoVhss-hl..........tthHGshhaccLpphDsSphalDsVsph.h...........	0	20	44	61
+11035	PF11203	DUF2984		Protein of unknown function (DUF2984)	Pollington J, Finn RD	anon	Pfam-B_003006 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed.	21.30	21.30	21.30	21.40	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.14	0.72	-3.89	22	356	2009-09-11 11:43:42	2008-08-08 15:46:26	3	2	151	0	77	242	0	95.90	31	21.98	CHANGED	PAsupRpTWlsLRhcsppshtAlptR..............sts..ultpslssuspRlAspLtspGhsApshpusEhspssstlstt....................................+EsWcthcstsu.assuYtls	............ssupRcTWlsLRhs.spcs..htAlptR.............................sts.hultcshhsuupRlAscLcspGhcAps.s.sus-l.schssshu..s..........................................................cEpW+sl+.ttsu.ahsuYth........................................	1	18	50	70
+11036	PF11204	DUF2985		Protein of unknown function (DUF2985)	Pollington J, Finn RD	anon	Pfam-B_003090 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.00	20.00	21.00	27.60	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.85	0.72	-4.23	20	240	2009-01-15 18:05:59	2008-08-08 16:59:53	3	12	109	0	186	235	0	78.80	38	14.21	CHANGED	h+alpTPhGFhlTlYuh.lshWGuhlhLhLlshlsh........ssup+chWIElssQILNALFslsGhGLAPaRh+DhYahlhht	..................h.palppPhGhhlslYuhhlssaGuhlhLlLhGhls.h................ssup+phWlElssQlLNALFslhuhGlt.PaRhhDhahhhph.............	1	43	96	150
+11037	PF11205	DUF2987		Protein of unknown function (DUF2987)	Pollington J, Finn RD	anon	Pfam-B_003120 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	25.30	25.30	20.30	24.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.78	0.71	-4.54	25	171	2009-01-15 18:05:59	2008-08-08 17:07:43	3	1	169	0	42	124	3	144.00	43	67.67	CHANGED	stAps.lslpYssFYs+LKpssKtsaphVcluFhlscsps.t..CpIpsuplssEccptsLslosspcL.hlPhDcsL+ss+ALlsls.s..spuppCsluhQVhAKp.....hptphotscLtplhspMcshLschuGhhs+....aFtPclsGlshcFs	..............................................App.hhhoYScLaophKsNs.KEsHsDV+huhaFsDspopp..CsIcKAaMEKE.-HYEpLslssupEL.hlPlDssL+pANPLVhVs.o..sp-ccCDhSMhVhAKcs....hpuclohpclpsLlsQMpshL-pLGGMFuu....aFsPsVpGVTlEFs............	0	6	16	29
+11039	PF11207	DUF2989		Protein of unknown function (DUF2989)	Pollington J, 	anon	Pfam-B_003139 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as lipoproteins however this cannot be confirmed.	20.90	20.90	20.90	54.50	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.47	0.71	-4.87	26	162	2009-09-10 14:55:00	2008-08-12 09:52:50	3	1	160	0	37	114	8	199.60	47	74.36	CHANGED	hLsGCtp..stsssplCcssPpL.CsDLs.cDuaCRhcRs-LIhpRaplpc..sPospppYppLphlEsYpKClELAutIpaIppp-+pscRhcAhhpShpplpcLpppT+sSp-PtllYY+WophsDpsAhpphLthEspspl.pssElQhuLAoYYh+pDspKshpLLh+sLpLhpts................phN....................s-llpuLAolappppshcpAYlWuhl	.....LsGChE..pcsT-plCtsNPpL.CppLN.cDGQCRl.RT-LIW+RF-lhK..sPoDcpplcEhphlpsYcKCLELASQ.IQsIcpochKpsRhsALlpSscE.cRlst-L+pSpsPpsLYahWSQhGDpsAp+tFLplEGpscL.cT.AEMQaALATaYo.sRDp.KTlpLLp+sLcLsstp................slN....................s-lLcuLAShapthpch-cAYlWAhl......	0	6	13	25
+11040	PF11208	DUF2992		Protein of unknown function (DUF2992)	Pollington J, Finn RD	anon	Pfam-B_003142 (release 23.0)	Family	This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologues of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesise nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches [1].	23.80	23.80	27.80	27.60	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.82	0.71	-4.25	29	465	2009-01-15 18:05:59	2008-08-12 10:41:15	3	3	432	0	61	366	9	127.70	37	93.45	CHANGED	LTlaFDs.FWlGlhEphp.sschcls+lsFG.sEPpD.ElhcFlhpch.s.Lphspshtsph......pp++hNPKRhQRpsp...Kchcp.tsluTKAQpAlKhphEppKpc+KptsKpcKcptpcp+aplKppK++pKH+GH	..........LTVaa-s..tFalGlhEpp.c...p..........s.......p..........hpss+hsFG.sEPpDtElhcFlppp.h......hp.Lpassthtsph...........pp+phNPKRlQ..RpstKp..hpp....tthu.TKAQpAl+hphEtpKpc+Khpp+pc+-tp+p++htlKppK.t+pKH+GH.................	0	24	41	48
+11041	PF11209	DUF2993		Protein of unknown function (DUF2993)	Pollington J, Finn RD	anon	Pfam-B_003144 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	27.30	27.30	27.40	27.40	27.00	27.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.45	0.70	-4.44	148	794	2009-09-11 14:20:34	2008-08-12 10:49:44	3	4	452	0	220	612	29	216.40	16	79.06	CHANGED	sssts...................hsthhpptlsptl.psph..ph........spss.pVplsuhP.h..pllpGcls.............plplsspsshh.....sht.....ht...phplpsps.lplshsth...........h.st..hphhp.....sspssspltlstsslsptlss..t.........hpth...................................hspsplplsu.....................................lshpsph......pl......tpt.............h.lphsshp.ht.s........h..............hsthhpths..h..sht...t..........hshsl.plp..plp.lpssslplps.p	..........................................h....shthhscptlsppl.ppts.......t..........ssss..pVslt.s.hP.hlh.plh...sGcls.............plslpstssph.....sht.......ht...........phphshcs.lclshssh..........h........phhp......ssplsusstlst.splschlst.........t...........htth..........................................sts.s.plpltu....................................h.lslpssh..............pl...............ssst.............thhlphssss.huhst.....................h.......................................................................................hpslhpshs.tph.....shtp.............hshsl.phs..slp.sssssl.hph...............................................................................................................................	0	56	159	205
+11042	PF11210	DUF2996		Protein of unknown function (DUF2996)	Pollington J, Finn RD	anon	Pfam-B_003176 (release 23.0)	Family	This family of proteins has no known function.	21.90	21.90	23.60	28.90	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.57	0.71	-3.83	21	102	2009-09-11 16:37:34	2008-08-12 14:04:55	3	1	88	0	45	104	110	115.30	41	66.98	CHANGED	tlE-KPFsEFlppchlPuLppuLpsc.GlsshsLshtcsphPlsG....spCWhVhGchsts....RpFWLsFspcsIsusKshuLA-sGscPShlESFLIDE++lTLsLLlsRllQRLNGQKWLGs	.....hEcKPFsEFhppchlPuLppuLppp.GlsslcLsFpcs.hsh.h....t.h.plpGsa.pst...+pFhlaFsptsIpG..KuFohussGspPSTlEsFL.IDE+...+lTLcLlVhhllQRLNGQKWLs.h................	0	7	30	41
+11043	PF11211	DUF2997		Protein of unknown function (DUF2997)	Pollington J, Finn RD	anon	Pfam-B_003181 (release 23.0)	Family	This family of proteins has no known function.	20.80	20.80	21.90	21.30	20.60	18.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-7.91	0.72	-4.58	41	147	2009-01-15 18:05:59	2008-08-12 14:10:29	3	1	124	0	60	136	151	48.10	38	65.72	CHANGED	lcapIpsDGpVcEpVpGlpGpuCpchTctlEssLGsVp.pcchTuEaat	...........lcahItsDGcVptpVpGltGpuCpchTptl.EstLGsVh..spchTsEaa..........	0	22	47	58
+11044	PF11212	DUF2999		Protein of unknown function (DUF2999)	Pollington J, Finn RD	anon	Pfam-B_003194 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	26.70	134.00	22.90	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.78	0.72	-3.94	10	145	2009-01-15 18:05:59	2008-08-12 14:26:43	3	1	145	0	26	66	7	81.80	78	97.98	CHANGED	MNPIIAlLKEHNVSDEQIsELFQsLT-NPhhAMAhIsQLGIPsEKLQtLMulVMsNPuLIKEAVEELGLDFuKVEAAKA+Lp	MNPILAhLKENNISsEQINELFQTLTQNPLAAMATluQLGLPQDKLQhLhAQVMQNPALIKpAVEELGLDFuKVEAAKAKLQ.	0	3	7	17
+11045	PF11213	DUF3006		Protein of unknown function (DUF3006)	Pollington J, Finn RD	anon	Pfam-B_003197 (release 23.0)	Family	This family of proteins has no known function.	21.50	21.50	21.50	21.50	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.21	0.72	-4.22	42	334	2009-01-15 18:05:59	2008-08-12 14:37:12	3	2	303	0	107	256	3	68.80	33	87.57	CHANGED	psllDRF.E....schAVlEhpscp.....hsls+shLPtsu+EGD.VLpl...........plplD.cpTcpt+...cclpchhccLhc	..........+sIlDRh.E.....sphAVlchcspp.......hsls+spLPp.ss+.E.GD.Vlhl......................ptsphplDtp-T-cc+...ccIpchhccLh...........................	0	52	85	101
+11046	PF11214	Med2		Mediator complex subunit 2	Wood V, Coggill P	anon	Wood V	Family	This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression [2].	21.10	21.10	21.50	22.00	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.42	0.72	-4.00	10	58	2009-01-15 18:05:59	2008-08-12 14:40:30	3	1	35	0	39	58	0	122.50	45	41.27	CHANGED	M.........................shcsKLssshDDIL+sSu.lh..p.l+sschpSsllTGhNspL.....ppsLsc+IspFauILD-s.spLNcocahl....Dslhp.+pcpc................EhK...EEEE+p++...........E-EE+K	..............NLps+Lp...ssLD-ILKoSGalh..ElIcpN++QSNlIousNNpLIp..lpppLsscIppFHuILDpTloKLNDAcWCL....sshlEp..KKKh-...........................EhK.lKEEtt...+K+c........EpEt..tcp.tct.........................................................................	1	18	27	38
+11047	PF11215	DUF3010		Protein of unknown function (DUF3010)	Pollington J, Finn RD	anon	Pfam-B_003238 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	77.50	77.40	19.00	18.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.52	0.71	-4.25	31	135	2009-09-11 10:24:04	2008-08-12 16:16:03	3	1	126	0	48	117	14	136.00	43	95.65	CHANGED	M.+lCGVELKGsEAIlsLLshcsshaslP-sRsp+hslscsssspsl+pFphsFscLhpDYpV-pVlI+cRtpKGKFAGuAsuFKlEAAIQLl..sslpVsLlSssslKppLK+sPh.lsFptsGLKpFQ.csAFpsAauhL	..M+lCGVElKGuEAllsLLo.hcsssasls-sRsp+hslscsssspsl+cFphsFtKLhpDYpV-cVVI+cRppKGKFAGuAsuFKlEuAIQLh..ssls..VpLlSPssIKpphK+sPh.lsFcpssLKpaQ.cpAFpsAYAh.....	0	8	17	36
+11048	PF11216	DUF3012		Protein of unknown function (DUF3012)	Pollington J, Finn RD	anon	Pfam-B_003254 (release 23.0)	Family	This family of proteins with unknown function is restricted to Gammaproteobacteria.	20.40	20.40	21.70	21.00	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.56	0.72	-4.27	16	235	2009-01-15 18:05:59	2008-08-12 16:33:21	3	3	142	0	40	118	13	31.90	62	64.02	CHANGED	VGSEsWCccM+-KPKGDWTANEAs-aAKHClh	.VGScuWCEDMcEKPKG-WTAp-As-aAKHClh.	0	7	14	29
+11049	PF11217	DUF3013		Protein of unknown function (DUF3013)	Pollington J, Finn RD	anon	Pfam-B_003257 (release 23.0)	Family	This bacterial family of proteins with unknown function appear to be restricted to Firmicutes.	25.00	25.00	35.40	35.30	18.90	18.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.98	0.71	-4.50	12	479	2009-01-15 18:05:59	2008-08-12 16:37:24	3	2	473	2	34	218	0	155.00	58	98.53	CHANGED	MuKhshLshL-Epl-Kp.FsaDhtlsWDKKNHAlElsFhLpApNssulchsDspGpsSsE-Il.FEDtlLFYNPsK.SpFD.t-DYLsslPY-sKKGlu+phLshFspaLp-sh-pG.sDLMDFL.sDsss-pFtLpW-spsFEpshsp..LpEs-...aYsYP+	...MApaGFL-lLEEELDKp.FsaDaplsWDK+NHAVEVoFlLEAQNs.u.uVEhlD--GElSs-DIl.FE-uVLFYNPuK..Sshs.tEDYLssIPY.PKKGhSREFLAYFAhFLKDsA-.GLcsLMDFL.pDs-AEEFshcWspEsFEcG+ss..LcEsE......FYPYP+...........	0	4	14	23
+11050	PF11218	DUF3011		Protein of unknown function (DUF3011)	Pollington J, Finn RD	anon	Pfam-B_003246 (release 23.0)	Family	This bacterial family of proteins has no known function. Most members belong to Proteobacteria.	25.00	25.00	25.00	26.20	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.02	0.71	-12.00	0.71	-4.54	5	96	2009-01-15 18:05:59	2008-08-12 16:42:20	3	3	52	0	30	104	9	167.40	36	75.04	CHANGED	VVRCES+DpcRVHCDhsscsGlQLVRQLSuoSCI+GSpWGoDRuGVWV-pGCRAEFsuu.....supGuuaPusst....hRRlVRCESNGs+p.SCPVtLRGAPVRLLRQLSlhPC+EGRoWGp++sEIWVScGC+GEFElAc--GpsFVDs...........PaoLTCESKsR+RRoCGsSlcpG.sVLppQLSuTPCEEG+oWGWS..RssVWVssGCRAEF	................................................lpCpSpc.tphcCsh.httts.LVcplStspC.cGppWs.c..ptt..lWVppGCRucFstt.......ts...shst............ttslRCcSs.stt...C..sshh.Rts..pLlRQhS.hPChcspsWs...ctsplWVscGCcGEFt.ut.....ts.G.....s.hssh.......................shhlsCpScppphptCshss.p..ht..shlhpQhSpo.C.EspoWGas..pstlWVssGCRAcF..............................................................	0	8	20	25
+11051	PF11219	DUF3014		Protein of unknown function (DUF3014)	Pollington J, Finn RD	anon	Pfam-B_003267 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	127.80	127.20	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.68	0.71	-4.35	31	126	2009-01-15 18:05:59	2008-08-12 16:46:51	3	1	121	0	57	133	68	160.20	37	55.15	CHANGED	-llR+hVVhlDNLApGphsp+htPlpsPptpFsVpc.......sspth....IssssYpRYDsasshlsulsspphsshYpchpPLhppAYsELGYPcttFsspllpAI-plLss.PhscsPlpls...........psuVhYpFADPpLEuLssuQKhLlRMGPcNs++lKutL+cl+p	..cllR+hVVhVDNLupup.lsp+h.Plpsst.....ppFpVsph................ssphh....lss.ssapRYssYVshlsulDspshsphYpchhPLhppAasELGYPc.tt.FN-RllpAI-hLLss.PtspsPltlh...........pspVpYpasDPpLEuLssuQKhLlRMGP-Ns++lKutLRcl+.s..	0	12	30	46
+11052	PF11220	DUF3015		Protein of unknown function (DUF3015)	Pollington J, Finn RD	anon	Pfam-B_003292 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.80	26.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.81	0.71	-4.59	16	196	2009-01-15 18:05:59	2008-08-13 09:16:49	3	1	165	0	52	142	74	138.20	38	88.21	CHANGED	AhAsustGs.GCGhGs.MlFpGpsGhssHlLAuTTNGTSGNpTFGMTSGTsGCsosu..slshsupshlhhss.h-pLucDMA+GpGEsLsuhAslLGlpspD+s+Fstlh+cpFspIFsst-s.TucclhsuhhslhppDspLuKYst	....................................h..A.Assss.GCGhGs.hl...FpG...Q..cGhss+lLAuTTNGT.GNt......TFG.hToG.TsGCpssu....tl.shsucshhhhss.h-pLucDMAhGpGEuLsshAslhGltspD+scFstls+ppFu.pIFsssss....outpVhssh.slhtpD.hLttYs............................	0	17	31	44
+11053	PF11221	Med21		Subunit 21 of Mediator complex	Coggill P	anon	manual	Family	Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator [2].	28.80	28.80	28.90	29.10	28.40	26.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.78	0.71	-4.22	30	284	2009-01-15 18:05:59	2008-08-13 10:00:02	3	4	250	3	206	269	0	134.00	30	86.37	CHANGED	MuDRL.......TQLQssLDQlspQFsuolsalspspsss.hsssp........................phustpsss...........................................................sspsFpsphcELupDlllKs+QI-hLIsSLPGlssStccQh.cpIccLpcELpplEp-+tctl+ct-pLLccl-pllsslspu	...............................................MuDtLTQLQssls..p...lAppFssslshlpppts.sphss.p...............................................thsptps.................................................................spshppttp.hApslhhps+..pI-...hLIsoLPu....-..s..otptQh..pplpcLpc.E.cpstpphpcslpct-.tLLcclpshltslsp.s................................	0	67	112	168
+11054	PF11222	DUF3017		Protein of unknown function (DUF3017)	Pollington J, Finn RD	anon	Pfam-B_003304 (release 23.0)	Family	This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.	25.00	25.00	25.30	25.60	23.30	24.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.54	0.72	-4.19	44	367	2009-01-15 18:05:59	2008-08-13 13:05:21	3	1	325	0	76	203	15	71.80	41	71.31	CHANGED	PILlVshlhssuhsLssusaWRRGALlIGIGVGlAAlLRLsLo--RAGLLsVRS+sIDFlTTsTVuAAMlYIAhTI	...............hhhhh.hhhhuhl.ls....h....s..s....aW..RRGshllGhullhAAlLRlVL.s-pp..AGLL.uVRSRhlDhlhhss....lGAsMVhlAhTl.....	0	25	60	73
+11055	PF11223	DUF3020		Protein of unknown function (DUF3020)	Wood V, Coggill P	anon	Wood V	Family	This family of fungal proteins is conserved towards the C-terminus of HMG domains. The function is not known.	25.00	25.00	27.60	27.60	16.50	17.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.42	0.72	-3.56	11	47	2009-01-15 18:05:59	2008-08-13 13:24:13	3	3	35	0	35	50	0	48.80	43	5.16	CHANGED	NRcRKK+.WRctNuc+NK-NDL+SRlh.....KKApthaGpcso.tcKpsWh--EF	.....N+cRK++.WR-tNsp+N+-sDLRuRlp.....KRAsthFG.cp-o.tcKppWl--EF..	0	12	25	35
+11056	PF11224	DUF3023		Protein of unknown function (DUF3023)	Pollington J, Finn RD	anon	Pfam-B_003319 (release 23.0)	Family	This bacterial family of proteins with unknown function appear to be restricted to Alphaproteobacteria.	20.30	20.30	22.90	22.20	19.80	17.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.58	0.71	-4.49	35	63	2009-09-10 17:53:36	2008-08-13 13:36:20	3	5	5	0	38	59	0	122.90	21	52.07	CHANGED	shCIGpT.s.ssspLplhlsps.....pppphhsh...spGpSLFhlpsplssphlppst..pLpphhthsppp............spslphshYhLVsppslppFhp.stp..................ptphhshpslspaGsllhs+.....tpsshhch............FsEpcsLp	...........................hhCIGpT.t.ssspLhlhhsps.....p.pphh.....spGpSLFhlpsplssphltps...tLpp..hhthsppph...........pthlphphYhLVpppplppFhp.h.p...................tthh.hpslsphuphlhsp.....httt.hph............hsEtphL..................	1	8	8	8
+11057	PF11225	DUF3024		Protein of unknown function (DUF3024)	Pollington J, Finn RD	anon	Pfam-B_003325 (release 23.0)	Family	This family of proteins has no known function.	21.20	21.20	23.00	22.60	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.80	0.72	-4.09	30	192	2009-01-15 18:05:59	2008-08-13 13:40:33	3	1	180	0	35	131	2	57.50	36	48.42	CHANGED	thpsslA+lpaspspstWplahhcps......hcWp.Yp...cspsLcthLchlpcDspusFW	......hppslAKlhapcu.....pppWtLYhhcpp......ttWh.Ys.hspspsLoshlctVccDPcuhFW..	0	14	20	32
+11058	PF11226	DUF3022		Protein of unknown function (DUF3022)	Pollington J, Finn RD	anon	Pfam-B_003318 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	25.30	25.10	21.70	19.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.35	0.72	-4.19	13	102	2009-01-15 18:05:59	2008-08-13 13:42:54	3	1	53	0	25	82	4	109.60	39	85.85	CHANGED	-hsEL-pslsD.Fs-posssVHsDspoGRlplpluWltss.suss+thRpuVsLsh-ssslcRYAsLDsusRhRV+AhL+DhVcssL-p....LEDtptc.psVsl-lTss.LDsA	....chsELs+llsDhFP-Q.ophs.+sD.psGR.l.lpVpWluhRhuuos+..RpolslRhssssLtRYhuLcshtRuRs+AhL+AhscAsLsu....LE-p...cAsupsVsh-sT.htLs-t.........................	0	2	4	12
+11059	PF11227	DUF3025		Protein of unknown function (DUF3025)	Pollington J, Finn RD	anon	Pfam-B_003327 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.	25.00	25.00	59.80	47.00	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.46	0.70	-4.83	21	157	2009-01-15 18:05:59	2008-08-13 13:46:56	3	3	155	0	60	158	30	208.90	45	74.55	CHANGED	PlRFVsQst..LPsGpAYEsaIapTGpVPTR.-NLHDFFNALlWLpFPcsKstLNtlputsIupt..Glt.sh..RGslRDAlTlFDENGllll.uss.....sLtss.................Lcs+pWppLFlcpRstWt........ppspshhFGHALhEKLlpPaKulTAHshhl.l..sst.h..shsp.puhL-tpLs.....httushhss+sFuPLPlLGlPGWas-NpssuFYcDopVFRPtRR	...........lcFlsQss...LP.sGhAYEsaItpTGpVPTR.cNL...HDFFNALlWhtaP+hKutLNApQuss...Istt.....Gl....u..ss......RGslRDAlTLFDENGslhssu-.s.....s..Lt..sA.................Lpu.a-WppLhl.ppRstWs.........................s.pscshlFGHALhEKLl.sPaKulTAHuhhVpV..ssshh.th.....stsppp...............uhLDtpls......................tspthss+sasPLPlLGlPGWhstNtssuFYsDstVFRsuRp.............................................	0	10	35	48
+11060	PF11228	DUF3027		Protein of unknown function (DUF3027)	Pollington J, Finn RD	anon	Pfam-B_003334 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	26.80	25.90	24.90	18.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.32	0.71	-4.63	20	441	2009-01-15 18:05:59	2008-08-13 13:56:36	3	3	428	0	110	316	124	189.60	48	66.63	CHANGED	G-HLGspsEu-+lsTHhFtsphPGYpGWpWAVTVu+sscucplTVsElsLlPGssALlAPcWVPWp-RlRPGDLGsGDLLPsssDDPRLssGa.......................................ssssDstl-.................psshELGLGRpRVLSttGRppAAcRWY-G-tGPcothA+sAP..ssCsTCGFalPLuGuLsphFGVCANEhuPsDG+VVuhDHGCGAHSEs.l	...........................................G-al.GshsE...s-plsTHhFtsphPGYcGWpWuVslupss...c..u..cp.sTVsElsLlPGt..cALLAPpWVPWc-RlR..P..GDl...us.....GDlhssss-D.PRLtPGa..........................................................................................s.s.stD.st......................tsstE.lGLGRp+lLSt.GRspsApRWhsGphGPcsshu+...pAs....tsCso.CGFalsLsGoLst.hFGVCuNEaS.uDG+VVphcaGCGuHS-s.s...........................................................	0	32	80	102
+11061	PF11229	DUF3028		Protein of unknown function (DUF3028)	Pollington J, Finn RD	anon	Pfam-B_003337 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	19.00	19.00	20.50	25.00	18.20	18.40	hmmbuild  -o /dev/null HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.87	0.70	-6.24	3	60	2009-01-15 18:05:59	2008-08-13 14:00:20	3	4	42	0	35	71	0	530.00	60	38.40	CHANGED	MNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGNRLLPAWIKlVLTEGAPTMLCLAALHGMVALVGSEGDVMQLKSEAIQoSHFQGRLNEVIRTLTQVISVSGVIGLQSNAIWLLGHLHLSTLSSNQSRTSVPTDYSYLPEuSFIRAAIGFFITGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAoLLGLWVMPPLIHGLSLNIKKYLLlSsPLWIKHlSDEQIlGFVENLMVAVFKAASPLuSPELCPSALQGLSQAMKLPSPSHHLWSLLSEATGKIFDLLPNKIRRNDLELYISIAKCLSEMTDD-ANRVAQITKSNIEKAAFVKLYLVSQGRFPLMuLTDlLSVAVQHREKETLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSlQNVALDEALDFLLLIFAAAVVAWADHsAPLLLGLSASWLPWHQENGPAGPAuSLLGRSPMHRVTLQEVLTLLPsSMsLLLQKEPWKEQTQKFIDWLFSIMESPKEALSAKSKDLLKATLLSLRVLPEFKKKAVWTRAYGW	.....................MNKLRhLsEssQQTSGFALALGNlVHGLSVCGHGKAEDLus+LLPuWI+lVLsEGsPTMhCLAALpGhVALVGSEuslhQLKS.EsIQoSpFQuRLNEVIRTLTQVISlSGVIGLQSNAhWLLGHLHLSoLSSsQSRsSVPoDYSYLPEsSFIRAAIsFhlsG...GKK..G..PEuVPPSLlKlVMKPIAoVGESYQ..YPPVNWAALLSPLMRL.NF..G...EEIQQLCL.EIhVTQA.....QSSQNAAsLLGhWVhPPLIHuLSLshK+YLLlShPLWhKHVSDEQI..uFVEsLhVslF+suS....hssPELC.SALQGLSQ..AMKLPSPu+HLWSLLs-ATtKIFDLLPNKIRRsDLELYIulAKCLSEMTD--.ssRlsQlTKuNlEKA.AFV+LYLVSQG......RhPLhsLsDlLosAlp...HpEKEsLAWMlLHSLYQAR.I.VSHA.NTGVLK....RM.EWLLELMGYIR.NVAY..QSTShQNs.sLcEALDFLLLlFAsAVVAWADHs.APLLLGLSASWLPWHpEsGPuG...ss.suhLG+SPhcRVTLQEsLTLLPsSM.LLLpKEPWKEQTQK..FIDWLFSIMEuPcEuLSApS+DLLKATLLuLRsLPEFKKKAVWTRAYGW.........................	1	6	8	17
+11062	PF11230	DUF3029		Protein of unknown function (DUF3029)	Pollington J, Finn RD	anon	Pfam-B_003347 (release 23.0)	Family	Some members in this family of proteins are annotated as ykkI. Currently no function is known.	23.00	23.00	23.10	23.00	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.60	0.70	-6.31	19	631	2012-10-01 23:28:04	2008-08-13 14:10:42	3	1	584	0	51	368	5	448.40	70	94.14	CHANGED	sLoh+QKpphLAhEAEssLshhplsstspcth....cpGlICDhFEGaAPa+PRYlLPDYA+FlppGScaLELsPspDlDEALNsLhIlY+HVPSVTshPVYLGpLDsLL.PFlpths--plYpKLKhFhlhLDRTLPDuFhHsNIGPsDshhsRhIL+l-uELKQssPNLThhYD.-lTPD-hlp.AspshhpCSKPahANashaspsas.psaGIVSCYNuLPluGGu.TLVRLNL+plAc+Apu.h--FhsplLPcYsphhhplI-sRtpFLhEESpFF-o.FLV+EGLIccsRFssMFGIaGhAEAVNhLlpp-shpp+..............YG+scpANpLGhpI.ppLsclVsspsstY..uhssRhLLHAQuG..I.shDpsVTPGsRIPhGcEP.-.lsHlpssAtaHpYasSGISDIhslDcTl+pNP-AhlslsKGAhshGhR.FTsNlussDLlRVTGYhVKhSDltKacp.cuuRpNTThLGutAscNoplhpRps.R	...........................................................V.LoPEQKRHFLALEAENs..LPY.Pp.LPs-ARcAL....DEGVICDMFEGHAPYKPRYVLPDYARFLANGSEWLELEGAKDLDDALSLLTILYHHVPSVTSMPVYLGQLDALLQPYVc.ILTQDcIDlRIKRFWRYLD.......R..TLP.DA.....FMHANIG....P....uDoPlTR.....AI.....LR.....ADAEL....KQVuPNLTFIY......DsEIT......PDDLLLEVAKNICE.CSKPHIAN..GP.V.aDKIF.......T......K...G....tYG...........IVSCY.........N.........S..L.........PLuG..GG..STLVRLNLKAlAERS.c........S..lD...DFFo.RTLPHYCpQQIAIIDuR...........CE...........FLYp....pSHFF..ENSFLV.......KEGLIsP..E......R..F.......sP.......MFGMYGLAEAVNLLCEpEG.lsA.R..............YGKpssANElGYRIS....AQLA-FVsNTPVKY.................GWppRAh..L..H.AQS..G...I...SSD.I.G.TTPGARLPYGDEP.D.PITHLQTVAPHHAYYaSGISDILTLDETIKRNPQALVQLCLG..AFK.AGMREFTANVSGNDLVRVTG..YMVRLSDLEKaRA.EGSRTNTTWLGEEAARNTRILERQPR......................................................................................................................................................................................................................................................................................	0	14	27	38
+11063	PF11231	DUF3034		Protein of unknown function (DUF3034)	Pollington J, Finn RD	anon	Pfam-B_003362 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	27.80	26.70	19.90	23.60	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.44	0.70	-5.02	28	135	2009-09-11 03:37:16	2008-08-13 14:21:12	3	1	128	0	44	144	8	247.80	49	87.40	CHANGED	ATGGloslEGuAGGGIsPWAlluGYuocsEhGuouhhTcVslsDYsLsshGAuluhtsRlELShA+QsFDlss....hust........................s.clpQDIhGsKlRLhGDllYsp...hPQlSlGlQaK+.c-.ts...............lspulGA.p-DpGoDhYluAoKLaLsuhhGpNlLlNsTlRuT+ANQhGLLGFGGs...pps.....sapl.hEuSlAllLs..+phAlGsEYRpKPDNLu..........hspE-DWtDlFlAaFPNK+LSlTuAYsDLGsIAsh.......ccQpGhYLSlQu	......ATGGsopIEGSuGGGIsPWAsluGYuopsEhGs.oAasT+lsls.DY..pLsVtGsul..uhsNRlELShA+QpFDlss..........htt.........................................s.plsQDlhGsKlRLhGDllYsp...hPQlSlGlQaK+.pD.hs................lPphlGA.ccDpGsDhYluAoKLahsuhhGhNlLlNuTlRhT+ANQhGLLGFGGs...pps............uhplhhEuSsAllls.....phAlGsEYRpKPs.NLu........................hupEsDWtDlFlAaFPNKHlSlssAYscLGpIAsh........csQpGhYLSlQ................	0	10	27	38
+11064	PF11232	Med25	Med25_PTOV1;Med25_PTOV-SD2; 	Mediator complex subunit 25 PTOV activation and synapsin 2	Coggill P	anon	manual	Domain	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [4].  The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear [3].	25.00	25.00	29.30	41.30	21.40	24.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.99	0.71	-4.54	7	184	2009-01-15 18:05:59	2008-08-13 14:21:37	3	11	64	4	76	182	0	147.60	62	31.02	CHANGED	.ppssp+.LhWSGsLEWpEps+s....sps+lp+oL.Cplhls.t-.p..lcT-pWPpKLhMQLIPppLLsslGshF.+sS+hV.F+.T..ssEsLcuLhphM...usGFAGClHF...PppssC-l+VLhLLYSsc+phFlGhIPpDQusFVptlRpVlspp+ps	...............ptlsNKhLAWSGVLEWQEKs+P...-sssKlpRoLPCQVYVNp..GE.s...L+T.-QWPpKLIMQLIPQQ.LLT.TLGPLF..RN.S..+h.VQFHF.......T...+.....Dh.EoLKuLhRIM....sNG.F.AGCVHF...Pap...u...sCEVRVLML...L..YSScKKIFhGLIPaDQSuFVNuIRpVIss+KQ.s.........	0	20	23	39
+11065	PF11233	DUF3035		Protein of unknown function (DUF3035)	Pollington J, Finn RD	anon	Pfam-B_003372 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Alphaproteobacteria.	25.00	25.00	25.30	28.10	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.91	0.71	-4.18	39	170	2009-01-15 18:05:59	2008-08-13 14:37:10	3	2	168	0	49	144	739	125.90	27	84.80	CHANGED	slsL...uuCut.....shpslttspssPDEFsllsptPLshPssas..LssPsPGssp.sD...sPpspAlsALsG..tt.......shssu-tuLlspAuphussssIRphlssE-tphtc+ssthsphhhhspsshhtshtpt..lcs.t-htthcp.sGstssuusP	......h.hhlouCut.....phtcsluhspssPDEapVhpptPLphPPsat..LssP..ssGt.s...p.p-....ssttpuh....tsl.s..............tshstupthllttu.st..t.tsshp......phthhtttt.h...hhh..t....s.....................................t...........................................	0	18	37	39
+11067	PF11235	Med25_SD1		Mediator complex subunit 25 synapsin 1	Coggill P	anon	manual	Domain	The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear [3].	25.00	25.00	53.10	52.60	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.54	0.71	-3.94	3	61	2009-01-15 18:05:59	2008-08-13 14:48:58	3	6	30	0	22	54	0	153.70	77	22.21	CHANGED	LPVGGu.SVPGsh.sKQ.VSLPPhsVlPPQluuAPQpPLPPV..pPPQMQVPQNsoLoAAHsAAQsAVEAAKNQKsu.uNRF..sslsPh.p.APuVGPPFSQsPAPsLPPG...P.hsPKPS....PASQsSLVTTVoPGsG.APV.hQQQssPQQPssPSMssTsAlGGV..QuPQPSQ.Q	.................LPVGGG.SAPGPLQsKQPVPLPPAsPSG.AoLSAAPQQ..PLPPV...PPQYQVPGN...LSAAQVAAQNAVEAAKNQKAGLGPRF.....SPIsPLQQAAP.GVGPPFSQAPAP.L.PPG...PPGAPK.PP.......PASQPSLVSTVAPGuGLAPs........AQP.GAPS.MAGTVAPGGV..SGPSPAQL.G........................................	0	1	3	7
+11068	PF11236	DUF3037		Protein of unknown function (DUF3037)	Pollington J, Finn RD	anon	Pfam-B_003382 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.30	21.30	22.30	21.70	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.27	0.71	-4.04	37	274	2009-01-15 18:05:59	2008-08-13 15:41:15	3	1	266	0	105	270	22	115.80	32	66.30	CHANGED	YAllRlVP+VERpEFlNlGVlLastpptaLts+h.plDc.pRLpuhssclDhchlpttLpuhptlCsGspsuGs..........luthshtcRF+WLoAsRSollQsStsHsGhss.DsstpL-+LhcphV	........YAllRhVP+VERpEFlNlGVllast.p...ppalps+h..plcp..sRLpshs.s.ch......D.hsslcttLcuhcplstGsppuGs.............hut.s.h...spRF+..W.LsAsRSo..llQsS.sHsG..hss...D.ttpLc+LhcphV.....................................................	0	46	87	101
+11069	PF11237	DUF3038		Protein of unknown function (DUF3038)	Pollington J, Finn RD	anon	Pfam-B_003387 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	25.00	25.00	58.10	58.00	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.74	0.71	-4.45	26	109	2009-01-15 18:05:59	2008-08-13 15:46:52	3	1	71	0	43	118	119	162.30	35	84.26	CHANGED	hs++spp+LDLLLLAlEuLslsuuEuhLtsuppLsLpshhssRVpLW+hRssNPlR+us.pRpsLshtEscALlhllsthAcphpshlRplL......supp.s.hspthhupahcRFpshhpcRMN.+Rutl.hh.s.spphspLthcLLhpLhhsoGssGhpRLhhSLhD	......cphpppLDLlLLAlEuLshsuuEshLtsuppLsLpshlssRlsLW+hRssNPlR+ut..tRppLslp-A+uLlhIlsahA+phpshIRphL.h.pQhpppphs.tpshhLupYl-+FpshappRMN.c+stl.hh..s.p-plspLAlpLLhpLLFsoGssGhpRLWhoLhD...	0	6	30	41
+11070	PF11238	DUF3039		Protein of unknown function (DUF3039)	Pollington J, Finn RD	anon	Pfam-B_003408 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	21.80	21.80	34.50	32.20	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.87	0.72	-4.52	19	435	2009-01-15 18:05:59	2008-08-13 15:55:13	3	1	428	0	112	273	89	58.20	56	62.78	CHANGED	psGDp-RFuHYV+K-KIhESAlsGpPVlALCGKlWsPsRDPc+.aPVCPcCKEIYEshp	....s.suDs.+FhHYVpK-KIs-SAVsGs.VVALCGcVassoRsPc.....PVCP-CKcIY-uhp.....	0	33	82	104
+11071	PF11239	DUF3040		Protein of unknown function (DUF3040)	Pollington J, Finn RD	anon	Pfam-B_003409 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.67	0.72	-3.93	28	478	2009-01-15 18:05:59	2008-08-13 16:00:21	3	1	392	0	158	361	191	86.20	37	67.41	CHANGED	MPLSEcEpRhL-plERuLhs-DPcFAsslpu........sshptsstRph....lhulsshVhGlslLlsGlshphhh......lulhGFllMhuuslhu	..................MPLS-cEQR.hLcplEpuLhs-DP+FAsulps..........................sthct.ss.tRph.........lhu..s...s.h..h.l.lG.LuhLVuGVshspsh.........LuVhGFllMhuushh.............................	0	67	123	152
+11072	PF11240	DUF3042		Protein of unknown function (DUF3042)	Pollington J, Finn RD	anon	Pfam-B_003420 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	25.00	25.00	32.60	31.20	20.00	18.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.51	0.72	-4.17	17	543	2009-01-15 18:05:59	2008-08-13 16:08:46	3	1	531	0	49	136	0	53.90	62	94.27	CHANGED	h+pFspGhlsGsluTluAlAGulhshKKslI-P.EcKtshIEENRK+AsRKphu	..KsFuKGllTGVsuTVAAVAGAVauhKKpVIEPEEp....KsAFIEENRKKAAR+RVS......	0	8	22	36
+11073	PF11241	DUF3043		Protein of unknown function (DUF3043)	Polligton J, Finn RD	anon	Pfam-B_003428 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.	25.00	25.00	79.90	79.80	23.10	22.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.16	0.71	-4.67	28	434	2009-01-15 18:05:59	2008-08-13 16:14:09	3	1	431	0	114	317	91	175.10	37	78.01	CHANGED	sKGRPTPKRcEA-s..................ARpR.......shs.p.-RKsu+ptpRsptpcccp+.ptuMhsG-EpYL.sRD+GP.RRalRDaVDuRhsluphhhPluLlllllhhl....ss.......splphh..sshshhllh.llhllDuhlLuR+lp+tlsp+FPc...psthulshYAhtRAhQhRRhRhP+PpV.cRGpp	.....KGRPTP+Rp-Acu.....................sph+.............pLs...p..-+Kts++ppR...tpt+c+ppc........uM.sG-...-...taL.sRDRGP.RtYlRDhVDSRh.slupahMPlALsllllhhs........s...........stlthh....hoh.shl.lll.llhlIDuhhLsR+lp+tlcp+FPs.......t.s.thul.shYAhsRAhQhRRhRsP+PpV.cRGc.t............	0	35	84	106
+11074	PF11242	DUF2774		Protein of unknown function (DUF2774)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	26.50	26.50	26.50	29.10	26.30	26.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.02	0.72	-3.98	7	26	2009-09-10 16:41:49	2008-08-13 16:41:06	3	2	25	0	0	18	0	60.70	49	66.55	CHANGED	hc.cVpVahh.+EtGhsFl-IA+th.slpup-suclWspV-pA+...tcFcs+EKVVYRK+hlN.Kh+p	...Mc.cVhVahL.HEoGhuFIEIA+cl.slpA+-sAhhWscscsAK...t+FcsREKVVYRKRhlNpKlKp..	0	0	0	0
+11075	PF11243	DUF3045		Protein of unknown function (DUF3045)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as gene protein 30.1. Currently no function is known.	21.40	21.40	21.90	73.90	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.02	0.72	-3.75	2	40	2009-01-15 18:05:59	2008-08-13 16:59:00	3	1	39	0	0	16	0	88.30	84	99.19	CHANGED	MFVVHsIh-sc.NTTRDYGHVN.FFRspP.FRu.KDtcIFKcCVEQGFIYl.caahpG.thR.TTYp+oLppL.DElhYNRsVsph.c.c	MFVVHTIYENEGNTTRDYGHVNQFFRCNPE...F..RAQKDERIFKKCVEQGFIYV....KHWM.....QGNKVR.TTYHRSLTELNDELIYNRAVNQTLKDE...	0	0	0	0
+11076	PF11244	Med25_NR-box		Mediator complex subunit 25 C-terminal NR box-containing	Coggill P	anon	manual	Domain	The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR [3].	28.40	28.40	28.60	28.90	26.10	28.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.34	0.72	-3.53	7	67	2009-01-15 18:05:59	2008-08-13 17:52:11	3	7	31	0	14	67	0	76.00	58	13.24	CHANGED	pppptstsshs...pQsht..p.............h......sstp...pQh.Q.hus..GQhhhpusspus....thp...ttpshtst....shhh.hh	.......................HLQPPGAPALLPPPHQGLGQPQ............LGPPLLHPPPAQSWPuQLPP.RAPLP.GQhhhuGGsRuPlspsGLQP....SVMED.....DILMDLI.........	0	3	3	4
+11077	PF11245	DUF2544		Protein of unknown function (DUF2544)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	25.00	25.00	25.50	70.20	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.63	0.70	-5.02	8	347	2009-01-15 18:05:59	2008-08-14 09:01:38	3	1	334	0	4	148	0	222.80	56	84.50	CHANGED	FaLsVsTPcuVtYGpYK..uhhhps-pLsllSWoG..uusAPolsLpDhsp.lspSsCPGLps.......osWs.CshhshsVhV-uDl..a.GCPWlVShassSpsPh......uhssYsGPss+sSlCPoVsVAsYDlSWsENYVsHsKsLpLQSTGGslEpTLSTYLMEsGKLCDGSpa...D-RGAYCRaVuQhlTFoooGCDsAcVTVTPscHPITDKQLHDMVVRVDTSS..RQPIDSTCRFQYlLNEL	.....F.loVlTPppVtYG.p.Yp...o.h..s.hpG-sLpllSWS...G...sssAPoLsLpDacs..lspSsCPGlst.......phap.CuhhThclTV.so.D.s..Y.GCPWlsSh..ashosss.......uhsoYouPTs+solCPolPVuoYDISWsENYVsHsKsLpLQSTGuslppTLSTYLMEuGKLCDGSpF...DsRGAYCRhVSphlTFoo.GCDpupVTVTPsRHPlTD+pLHDhVVpVsTSS..pQP.IDSTCRFQYlLNEL.............	0	1	1	2
+11078	PF11246	Phage_gp53		Base plate wedge protein 53	Pollington J, Finn RD	anon	PRODOM	Family	The baseplate of bacteriophage T4 controls host cell recognition, attachment, tail sheath contraction and viral DNA ejection. The structure of the baseplate suggests a mechanism of baseplate structural transition during the initial stages of T4 infection. The baseplate is assembled from six identical wedges that surround the central hub. Gp53, along with other T4 gene products, combine sequentially to assemble a wedge [1].	20.60	20.60	20.90	67.30	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.21	0.71	-4.84	12	70	2009-01-15 18:05:59	2008-08-14 09:05:47	3	1	68	0	0	63	1097	187.90	33	87.24	CHANGED	M.lFoaFsslcYtup.s.................ssIFRsa+hYastshhsaphcsYhlsGu.RPEplApplYGNspLYWllLMhNslhDPaasWlpsp-ssYphAtp+Ysps....splhaHhstpuc+a...aslVphPcsstsWYDh...............GspsppalpapGslts............VsshEtphhcNEp+RpItIlsssslpsFls-hhR.MEts	...............M.hFsaFssl.Ysspss.........tp....h.hpsIFRph+hhhchhthshhhcsYhIpsu.RPEplApplYGsspLaWllLhhNslhDsahsW.psp-shaptstp+Ysss....splhYalspc.spca...hsllphscs.tshY-h...............GshspphhphpsuLss...........................VssaEttlhcNEpKRpIpIlsss.lssFls-hh+.hEh.s............	0	0	0	0
+11079	PF11247	DUF2675		Protein of unknown function (DUF2675) 	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as Gene protein 5.5. Currently no function is known.	25.00	25.00	30.30	43.10	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.22	0.72	-3.93	5	48	2009-01-15 18:05:59	2008-08-14 10:08:16	3	1	22	0	0	46	0	89.70	54	82.40	CHANGED	MAMTK+FKVSFDVTAVlsSEsEcphc-sLl-LAKKAGAGEcl.oPh-REhLVQuLTHGsEGAsuFslKpGlREuIK-tasEhS..Dps.hKlSPATVREVF	...MshsKph+VoFphthhh.pp..tlLcK-hL+LsKpVGuGthV.Nu+Q+EhlVQhLTHGhEGlhoFVVRoShREAIKDMHEEYu..-KcoFK.SPATVREVF........	0	0	0	0
+11080	PF11248	DUF3046		Protein of unknown function (DUF3046)	Pollington J, Finn RD	anon	Pfam-B_3651 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	25.70	25.20	21.10	16.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.82	0.72	-3.99	23	439	2009-01-15 18:05:59	2008-08-14 11:27:04	3	2	408	0	109	273	72	60.60	40	73.10	CHANGED	MRLTEFaphlp-cFGsuYucslspDHVLusLGGRTsspAl-sGs-sRpVWpALCs-a..DVPtcc	.......MR.TpFaphls-tFGssaup.lstDpVLsuL.uuRTstpAl-cGl-s+tVWpAlCssh..-lPtp......	0	33	80	100
+11081	PF11249	DUF3047		Protein of unknown function (DUF3047)	Pollington J, Finn RD	anon	Pfam-B_3654 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.30	21.30	22.90	22.20	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.15	0.71	-4.90	39	127	2009-01-15 18:05:59	2008-08-14 11:30:24	3	2	110	0	59	135	779	187.20	27	71.98	CHANGED	ssuWp.hthss...tpTcYplh...pp....sspt.sl+AposuuASsLhpchslc.....ppssh..LpWpW+lsphhs..ssDtp............p+suDDhsuRlhVsFc....thshh.pht...............sLsYlWus.phshGsh..hsNPao.spsphlslpoGss.psGcWhscpRsltsDYc+sFG.........cc....sstlsululhoDoDNTsspupAaYGDIpl	..................................................tsWp.hth.t...ttopYphs..pp.......tsttsLcupucsuuSsLhp...p.hs.lc......hppssh..LpWpW+lpphhs..ssD..tp............p+suDDhshRlaVsFc.......thshh.pst................sLsYlWus.p.....tshGsh..hsNsas...s+sphll........lcoGss.psGpWhsccRslhtDac+sFG.........cc....sstlsululhoDoDNTtspupAaauDIth.............	0	18	40	53
+11082	PF11250	DUF3049		Protein of unknown function (DUF3049)	Pollington J, Finn RD	anon	Pfam-B_3659 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	29.00	27.60	24.70	21.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.83	0.72	-4.20	24	167	2009-09-11 15:04:28	2008-08-14 11:41:50	3	2	18	0	118	149	0	55.40	38	19.82	CHANGED	psFPPPlsolsttt......sthhhRscRc-GRLVlptVpsss.tp..hhpApRpsGRLpLphs	..........sFPPPlsolu..pts.........s.lhhRspRp-GR.L..l..LptVp...lss.pp...hhcApR.psGRLpLphh........	0	11	68	95
+11083	PF11251	DUF3050		Protein of unknown function (DUF3050)	Pollington J, Finn RD	anon	Pfam-B_3661 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.20	22.20	25.70	23.60	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.61	0.70	-5.12	32	145	2012-10-02 21:56:19	2008-08-14 11:51:00	3	1	136	0	65	178	375	227.80	46	88.88	CHANGED	pLhpHsLYpplpol--LphFMEpHVFAVWDFMSLLKuLQppLTssssPWlP.stssphtpLINEIVluEEoD.shpG.....thtSHFEhYLcAMccsGAsTptIcpFlphlppG.sl.tAlppsslPtsstpFlphTaclIpsupsHplAAAFsaGREcLIPsMFppllcph...shsppphspF+YYL-RHIELDuD-HGPhAhpMlppLCGsDspKapEstpsuppALcpRltLWDuI	...............................................LhpHPlYsplpolcsLphFMEpHVFAVWDFMSLlKpLQpcLTCsplPWlP.ssss.pstRLINEIVLuEESDpt.sG.......tthSHFELYLcAMc-sGA.sTptIcpFlphlp......pGhsl............tpALpp.s......s......lstssppFlptThchltputsHp.......lAAAFsaGREclIPsMFpsllcch...shs.spphspFpYYL-RHIElDu--HGPhAhphlscLCusDsp.+hpE.shpsuhpAlpsRlpLWDul.........	1	30	51	58
+11084	PF11252	DUF3051		Protein of unknown function (DUF3051)	Pollington J, Finn RD	anon	Pfam-B_3671 (release 23.0)	Family	This viral family of proteins has no known function.	21.30	21.30	21.90	299.10	19.20	21.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.33	0.71	-4.81	5	73	2009-01-15 18:05:59	2008-08-14 11:55:00	3	1	1	0	0	64	0	189.00	94	84.08	CHANGED	WLEHIRLIVVTMVPILLLPDTTIGRHIHIKRQYLQSVLLWLARNKLYYRVKRCRSKRFVLEQDHIGPELFRTQLLQYAGLDVFQDVARLQDFLERGYDTFRSVLGVHLLEHERFVSRILEQPIMEPDQAVRLCFHYHNTLDHDDDDSGLETDFNNLSLGRPYINGLPPNEKIIFIHSNLVGHSTsSHDI	WLEHIRLIVVTMVPILLLPDTTIGRHIHIKRQYLpSVLLWLARNKLYYRVKRCRSKRFVLEQDHIGPELFRTQLLQYAGLDVFQDVARLQDFLERGYDoFRSVLGVHLLEHERFVSRILEQPIMEPDQAVRLCFHYHNsLDHDDDDSGLETDFNNLSLGRPYINGLPPsEKIIFIHSNLVG+STYSHDI...	0	0	0	0
+11085	PF11253	DUF3052		Protein of unknown function (DUF3052)	Pollington J, Finn RD	anon	Pfam-B_3674 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	20.90	20.90	20.90	20.90	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.37	0.71	-4.54	19	439	2009-01-15 18:05:59	2008-08-14 11:58:01	3	1	432	0	121	286	61	125.90	48	86.46	CHANGED	Ap+LGhpsGtlVQElGaD-DsDp-lRcAlE-shGs-LlDEDs--VVDsVLLWWR.--DG...DLsDuLVDAhssLu-sGhlWlLTPKsGRsGaV-Pu-IuEAAsTAGLsQTousslGstWsGoRLlt.P+u+	......................................................Ap+LGhpsGplVQEhGWD-DsD--lRpslE-hhGs-LlDE.DsD-slDlVlLWWR.--DG...DLsDsLVDAh.ssLu.-cG.hIWllTPK.sG+..s..GplpPu-..luEuAsTAGLstToohsluptWsup+LVp.+..t....	1	38	85	108
+11086	PF11254	DUF3053		Protein of unknown function (DUF3053)	Pollington J, Finn RD	anon	Pfam-B_3678 (release 23.0)	Family	Some members in this family of proteins are annotated as the membrane protein YiaF. No function is currently known.	20.70	20.70	21.00	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.55	0.70	-5.10	8	635	2009-01-15 18:05:59	2008-08-14 12:50:38	3	1	566	0	51	216	3	224.70	65	95.30	CHANGED	sRhFtP.....LLAlLlsh.LuuC.GDKEPEQRKAFI-FLQoplhcS.Gs+lPsLTs-QKcsFGsYssDY.AILosFSQphspAlsuu.pssltQhssIRospDhls+RDsLcpupsuLshlupplpssKupADsA+usLKQP-DLKsVaDpAas+TVosPAssLhsslPhssuhlpsLlpVGDaLpsQGsQVpFsuuu......lQFpsspQsspaNphlus.....LssQtpshhsAQpplsslt	.................SRWFAP.....lsALLMVlSLSGC.FDKEGDQRKAFI.DFLQNTVMRS.GERLPTLTADQKKQFGPFVSDY.A.ILYGY...SQQVNQAMDSGLRPVVD.SVNAIRVPQDYlT.QpsPLRphNGSLGVLAQQLQNAKLQADAAHuALKQ.s.DDLKPVFDQAasKVVTsPADALQPLIPAAQsFTQQLVhVGDYIAQQGTQVSFVANG......IQFPTSQQASpYNpLIuP.....LsAQHQAFNQAWTsAVss.s............................................	0	2	11	30
+11087	PF11255	DUF3054		Protein of unknown function (DUF3054)	Pollington J, Finn RD	anon	Pfam-B_3684 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	25.00	25.00	27.60	26.90	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.56	0.71	-4.23	34	368	2009-01-15 18:05:59	2008-08-14 12:51:26	3	2	352	0	112	243	15	107.70	39	76.76	CHANGED	hlluDllslllFsslGRtSHups....hsssslhtTuhPFLhGhhluhhls...tuapt........pthhssulhlWlsslslGhlLRsh..putusshoFll...VuhsssullLlGWRulst	......lsuDVlsVllFuslGR.t.SHucs....LsssGlhpTuhPFlhGhslGWlls........tshpt......s........sthh.sGlllWlsTlllGMllRth..oupGsu...s...s...Fll...VAsshsAlhLlGWRAls.u...........	1	33	85	106
+11088	PF11256	DUF3055		Protein of unknown function (DUF3055)	Pollington J, Finn RD	anon	Pfam-B_3685 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Firmicutes.	25.00	25.00	26.80	54.90	23.30	18.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.61	0.72	-3.85	9	448	2009-01-15 18:05:59	2008-08-14 12:57:36	3	1	339	0	39	150	0	80.60	55	88.16	CHANGED	LYDDsEps+sRFVuFhGEppRaDLullaTsRaaGKsLVlshQosRFAIlGtDDlcEsGYLp+lapl.sEE-ApELppFLtEl	..LYDDsEpopVpFVGFhG.E.c.oRYDLhLlaTsRHYGKTLVLsMQTNKFuIIGsDDLcE.GYltHlhul.stEEu-ElppaLpEl.....	0	12	23	32
+11090	PF11258	DUF3048		Protein of unknown function (DUF3048)	Pollington J, Finn RD	anon	Pfam-B_3658 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as YerB. However currently no function is known.	25.00	25.00	72.10	30.40	24.20	19.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.65	0.70	-5.27	32	284	2009-01-15 18:05:59	2008-08-14 13:08:54	3	3	253	1	96	284	560	276.90	28	78.69	CHANGED	PLTGhss...pch..ptRPlAVhlsNt.ssApPQuGLspADlVYEslsEGulTRhhAlat.....ophsctlGPVRSAR.Yalchu.ta.cuhasatGuS.....spAhshlcsss...lsslsu.....h....sushF...hR.sssRpAP....HNhYsohcpltpsspp.puhphptt.t..........t.ssssssGptspplplpa....stspssapYD.psptYhRhpsGpsplDtsT....GppltspNlllhcsphpsh...DstG+hs..h-lh......GuGc..uhlhpsGphhclsWc+..sstpshhthhstsGpplshssGpoWl	.........................LTG..ht..tth..ptRslAVhlsNp.....ssA.RP.QoGLspADlVYEhh...s...EG.s.l.......TRhhAlap.....sphscplGPVRSuRsYalplupta.culhlatGuo.....st.sh.shlppss.....lsplss..........hp......sushF............aR..sss.RpuP...............HN..hYsshpplt.pshpp..pGh.......ph..stp.phh...........................tts......sss...s...s..uptsp..plplpa............sttps.papYst.psptYhR......h..t.s........G......p......s......p........hD.tps...........uptlsspNlll.tsshpsh.......DstG.p....hs.....lchh..................uuGp..uhlhpsGchh.cspWp+........ss..sps.hhhhh..s.ts.G.p.......l.lssGpTWl........................	0	51	81	89
+11091	PF11259	DUF3060		Protein of unknown function (DUF3060)	Pollington J, Finn RD	anon	Pfam-B_3702 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed.	20.70	20.70	21.10	20.80	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.06	0.72	-4.35	29	317	2009-01-15 18:05:59	2008-08-14 13:35:01	3	2	141	0	67	209	0	62.90	38	39.12	CHANGED	sVuGssNslslsGsCssVTVsGssNpVss-s...lcp.lolsGhsNoV...................oYcsG.....sPpl.sspGus....Ns	....................sVsGssNolsls.GsCtsVTVsGssNpVssDs...lc..s.lslsGhsNsV...................sa+s.G.....sPpI.sstGssN.................................................................................	0	13	34	55
+11092	PF11260	Spidroin_MaSp		Major ampullate spidroin 1 and 2	Pollington J, Finn RD	anon	Pfam-B_001419 (release 23.0)	Family	Dragline silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2) [1]. MaSp1 contains five alpha-helices [2]. Only the C-terminus of the proteins are shown.	25.00	25.00	25.90	25.20	22.30	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.79	0.72	-3.90	26	173	2009-01-15 18:05:59	2008-08-14 13:44:16	3	9	43	3	0	180	0	82.40	52	17.94	CHANGED	susSRLuSsuAuuRVSSslSoLlSu.....GssssuuLussISslsSploASssGLSuC-llVQsLLElloALlplLuSAslGpVNhuus	.......suuSRLSSPsAuSRVSS...AVSsLlSu.......GssNsAALuNsISslsSQlSuSsPGLSuC-VLlQALLElloALlpILuSSsIGpVNhuus..................	0	0	0	0
+11093	PF11261	IRF-2BP1_2		Interferon regulatory factor 2-binding protein zinc finger	Pollington J, Finn RD, Bateman A	anon	Pfam-B_1430 (release 23.0)	Domain	IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and  C-terminal RING finger domains [1].	25.00	25.00	25.20	39.60	24.60	23.90	hmmbuild  --amino -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.75	0.72	-4.51	11	146	2009-01-15 18:05:59	2008-08-14 13:46:33	3	2	75	0	86	140	0	53.40	76	10.11	CHANGED	o+RQaCYLCDLPRMPWAMlaDFSEsVCRGCVNYEGADRIEhVI-sARQLKRsHG	...SRRQpCYLCDLPRMPWAMIWDF.....o..EsVCRGCVNYEGADRIEhV.I-oARQLKRuHG.................	0	21	31	55
+11094	PF11262	Tho2		Transcription factor/nuclear export subunit protein 2	Pollington J, Finn RD	anon	Pfam-B_002604 (release 23.0)	Family	THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability [1,2]. Tho2, along with four other subunits forms THO [2]	23.10	23.10	23.10	23.50	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.84	0.70	-5.37	35	353	2009-11-24 09:31:40	2008-08-14 13:48:43	3	7	271	0	252	345	7	279.40	35	17.64	CHANGED	pshshlsss.hassFWpLSLhDlthP..pchY-p..plp+lcpplpp..............tpsthpppp+chcplp..pphppLtsEtppH.hp+sppspppLpcppsp.Wh......ttsspplp........pFlppClhPRhlhSshDAlasu+FlphLaphpsstFshhshhcp...lhpsphLhshlhssTppEApNlGhFhsclLphlppWppcpp.hacc.s.......................hp.......p.pphhsac...papphla+Waphlhpslhp.........................................................................................................................sL..ppp-ahpI+.NulhhLppllshFPhlpphupplhptlcpltpp-............pRcDlplsusullupLp	........................hWpslosp.FYsTFWpLohYDltlP..pptY-c..Els+L+tphpsl................................................p-.pphs.s++c+..-+..cchp..sh.c+LhpEpccp.hc+hppshp+Lpp.c..Kc.p.Wh..................................tsscspplp..............phLQhClhPRslhSshD....AlYCu+Flc.hlH.p.pTPsFs.TlhhhDp.................lFp..s..lhhhlhsCTppEApphGRFLsphLcplt+W+s..-cs..ha-+Es...................................tshPGFhhhhc.................p.ss.lsa-...sF..++lhaKWHhplspuhhp.........................................................................................................................CL..pss-YhpIRNslhlLpcll..s..haPh..l...tph...uptlppplpclpppE.............pR.DlhhhAtuhhupL.........................................	0	96	149	211
+11095	PF11263	Attachment_P66		Borrelia burgdorferi attachment protein P66 	Pollington J, Finn RD	anon	Pfam-B_003349 (release 23.0)	Family	P66 is an outer membrane protein in Borrelia burgdorferi, the agent of Lyme disease. P66 has a role in the attachment of Borrelia burgdorferi to human cell-surface receptors [1].	25.00	25.00	29.50	39.60	23.50	19.50	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.44	0.70	-5.33	7	107	2009-09-11 05:11:33	2008-08-14 13:50:47	3	1	47	0	3	91	0	182.80	58	57.03	CHANGED	SDFSIhGHISKKAN........Tsccsp.FsPpsN+LpFsppRosNFAFSlGsGIGhAWNpD-GEKESWuIpGusSYSpRIFGpQDKKSGIGlGIoYGQNLY+PTSSN.plIQpIAtKoFpTLNAEISTYEDNKKGIIPGLGWIASIGlYDLLK-pPpSD..sIIssLTssTssp...sssps....loFscAsKl.GGALYIDYAIPlESIS.sTaIlPYVGsHhLG...SLpuScKolYLKsGLEL-pLIKLT	...............................................P.tNtLpFspppp.shtFShGsuIGhAWNpDpGEcESWtlpGupSYspRlFGtQDKKSGluhGIsYGpsLY+s..psop.phlppIutpuFQoLNsElSoYEDNKKGlIsGLGWIsSIGlYDlLRpKShEN...shhos.hosNppst.....oTssps.......loFp-AhKL.GhALYLDYAIPlcShSspsYllPYlGAahL.G...plp.sspplYLKsGLpL-pLI+hT.....	0	1	1	1
+11096	PF11264	ThylakoidFormat		Thylakoid formation protein	Pollington J, Finn RD	anon	Pfam-B_003380 (release 23.0)	Family	THF1 is localised to the outer plastid membrane and the stroma. THF1 has a role in sugar signalling [1]. THF1 is also thought to have a role in chloroplast and leaf development [2]. THF1 has been shown to play a crucial role in vesicle-mediated thylakoid membrane biogenesis [2].	19.80	19.80	20.10	55.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.27	0.70	-4.72	27	122	2009-01-15 18:05:59	2008-08-14 13:52:47	3	3	108	0	59	137	144	204.00	37	80.16	CHANGED	TluDoKRsFapsaP+sIsulYRRll-ELLVElHLLShpssFphDslFAlGlspsF-pFhpGYpPppchsslFsALCsussh-sppl+psApphtphspspshpplhpaLppt...stts.t.lts.htthttp.pa+YSRLhAlGLasLLppups...ttc.pphpchlcclupsLsLstc+VcKDLslY+SNL-KhpQAhELh-EhltuER+K+Ecptt	.........TVuDoKpsFhptap+PIsolYppllpELLVphHLlphppsFpYDslFALGlVTsa-phMpGY.Ppp-+suIFpAhhpA..lstDPcpYRpDApplpphA+ut.sssslhphhsp....ttphps.LtshhpthtspspFpYSRhaAlGLapLL-.uss........pcsphlcc.lspuLslspc+lp+DL-lYRusLpKhsQAhcllcEhlptE+KK+cppt.t........................	0	16	42	54
+11097	PF11265	Med25_VWA		Mediator complex subunit 25 von Willebrand factor type A	Coggill P	anon	manual	Family	The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex [3].	20.40	20.40	20.50	21.40	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.45	0.70	-5.32	5	158	2012-10-10 16:07:06	2008-08-14 13:59:46	3	13	86	0	84	159	1	182.70	42	27.72	CHANGED	Msss.Scu.hpt...VuDVVFVIEGTANLGPYFEoL+ocYILPsIEYFNGGPlsEo-..FGu-hGuTQYuLVVFNTsustPEshVQsauPTpssa-FlpWL-uIpFsGGGuESCSLlAEGLusALQhFDDhpcMRpplGQTshHRHCILICNSPPYlLPo..............sESsoYsG+TsDsLsslhs..ERuIaLSIIuPRKLPALRtLF-KAsssssl.s.possDYAK-PpHMVLl+Gls	...................................................s.lADVVFVIEGTAsLGPYapsL+ppYllPslEYF..suGs.s-pc...h.tp.h.sss.YulVVaposs.sh..spshlp.s.hu.Tpss.phlphlct......l.........pFhG.GGhEssu.lAEG......LusAL.thF-...-hpph.R.pt..h.......sps..p+hC.lLIsNS....PP..Y.hPs..............s-.sh..pa.pu.t..os....-p..Lst.ht..cpsIphSlluP.R+lPsLhhLap+Asss..h.......hshups.pahVLlps..s......................................................................................................	1	24	44	62
+11098	PF11266	DUF3066		Protein of unknown function (DUF3066)	Pollington J, Finn RD	anon	Pfam-B_3735 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.60	25.60	26.20	89.80	25.10	25.50	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.40	0.70	-4.64	15	78	2009-01-15 18:05:59	2008-08-14 14:55:13	3	1	74	1	27	84	174	214.60	68	92.46	CHANGED	DFsS-sYKDAYSRINAIVIEGEQEAHDNYIsLucLLPDct-ELp+LAKMEtRHhKGFpACG+NLpVsPDM-FA+cFFutLHuNFQpAhAEGKlVTCLLIQuLIIEuFAIAAYNIYIPVADPFARKITEGVVKDEYoHLNaGEpWLKtNF-osKtELpcAN+pNLPLVW+MLspVssDAclLtM-KEuLlEDFMIAYuEALssIGFoTREIMRMSAtGLs	.DFsS-sYKDAYSRINAIVIEGEQEAa-NYIsLupLLP-pp-ELt+LAKME.RHhKGFpACG+NLsVssDMsFA+cFFusLHsNFQpAhtE..GKlVTCLLIQuLlIEuFAIuAYNIYIPVADPFARKITEGVVKDEYoHLNaGEcWLKsNF-sSKsEL.cAN+tNLPLlhpMLsQVssDApVLuMEKEsLlEDFMIuYtEALssIGFooR-IhRMuAhuL.s.....	0	5	18	25
+11099	PF11267	DUF3067		Protein of unknown function (DUF3067)	Pollington J, Finn RD	anon	Pfam-B_3740 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	29.80	29.00	21.50	18.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.22	0.72	-3.92	16	113	2009-09-11 02:36:25	2008-08-14 14:58:43	3	1	93	1	61	110	105	98.80	42	66.27	CHANGED	ucElhpLLhc+WGtSYDlQLp+p+sR.....laLQVMWtYLEQtSFPLoEt-YhtHLsplsphLsthGtuptV+salpsT+-+PRL....GKAVSlPLcl...spRhsEal	...........................p-LtpLlhpKWG+SYDlQLh+p....c..tp......lalQ.......VMW.+YLEQpSFPL.oEpEYht+LsslAphLpsWGssppV+salpp.......o.......+-.......R.PRl.....G.K....A..VSI.l-h.....s.t+.sEah................	0	19	46	57
+11100	PF11268	DUF3071		Protein of unknown function (DUF3071)	Pollington J, Finn RD	anon	Pfam-B_3805 (release 23.0)	Family	Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.	24.10	24.10	24.70	53.90	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.98	0.71	-4.52	27	435	2009-01-15 18:05:59	2008-08-14 16:07:47	3	1	433	0	113	326	73	167.20	38	47.77	CHANGED	Mp-L+lVulssDGppllhpss....sG..ccaplslDDcLRuAlRts.............................................................hst.......splchEhss...................tLpPR-IQu+IRAGtosEcVAptuGhslp+VcRFttPVLtERs+sAchAptstssps............tsPu........TLuEllsptlss+Ghs.ssspWDAWRcs-spWhVplpapsutpsps.......AcWpas	......................M.cLplls.lpssuppllhpss.................u....ppahlslD-pLRsAltts...................................................................................................................phphphcs................................................sLsPREIQuRIRuGAosE-VAttuGlsls+VcRFAtPVLtERs+hsEhApsstsh+s............s.u.Push..........TLuEllspshsA+Gl.s.sslsWDuWRc-Ds...pWtlplpW.tuut..s..s..pp.........Acapap.............................	0	34	83	105
+11101	PF11269	DUF3069		Protein of unknown function (DUF3069)	Pollington J, Finn RD	anon	Pfam-B_3783 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.	25.00	25.00	71.90	71.70	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.76	0.71	-4.03	12	138	2009-01-15 18:05:59	2008-08-14 16:08:23	3	1	138	1	25	67	4	120.10	63	83.47	CHANGED	Vlsh-clPEpLh....shhsplhEssEtphpcuWsuLPASApslLsp.EpFHuhh.lupAahtlshlup.phs-hs-s.ss.pcpEYpu.lhs+lhcsslK-hlKpLKKARpDtshhpsh+pVht	VlEFDpVPEuMa....cMVTSIHEVSEEsVREAWDoLPASAQNlLDNFEQFHALlSVSQAFAGLNVMEEFPTLNLPcpMoEE-K-tYRAQLLDQVLHNCVKDMVKQlKKARRDPILKR-FK-VF.A..	0	2	6	17
+11102	PF11270	DUF3070		Protein of unknown function (DUF3070)	Pollington J, Finn RD	anon	Pfam-B_3804 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	28.60	28.60	16.90	15.70	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-7.18	0.72	-4.18	20	37	2009-01-15 18:05:59	2008-08-14 16:09:35	3	2	1	0	37	37	0	32.60	43	23.32	CHANGED	hAPsccPP...sE-sHEAP.sschssustpssssu	hAPscpP....sE-sH.uP..Schtsu.tsstspu.	0	37	37	37
+11103	PF11271	DUF3068		Protein of unknown function (DUF3068)	Pollington J, Finn RD	anon	Pfam-B_3769 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	25.00	25.00	25.60	25.40	23.90	21.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-12.03	0.70	-5.36	22	301	2009-01-15 18:05:59	2008-08-14 16:10:06	3	3	204	0	84	243	5	319.50	26	82.78	CHANGED	Rh...hushLhulGshhllhAlllshalsutltclPlDlssss..lstsssssh.s.stss.pt..thps..s.............ppphsstcstssDhlshpsspslhc.............scspphlpshssphslDRpouhslss..............psthssssh..shpGl.a+FPFcsE+coY.aaDshhppshshsasup...-slsGh..psY+FpQpls.sshs.................sh.hh.tt................sstssshshhYsssR.shW........V-PhTGslVphpEp.pchhsssstp................hshl-h.chshs-colps.lspAcctpsplthhschlPhshhhlGllshlsGlhL	....................................................................hushhluLG.ssLlh.hAlllstasssc.ltclPL..DlstTh....hop...s......s...s........s........shss......s..h.h.st....p...h..s.s...ssshsp.............................ppphsl.tssus...sD..s.lslplus..oltRtp.................................tpssssll.Ahs-phs.lsR.couhslsssst......................stpsss..ssl.....t+-Glp.Y+FPF.cTE.+.+..o.Y.aFDshspcshs....hsass-......ccl..sGh...ssY+FpQs....l.s.sslut.............................................tst.sh.hshssth.........................................sspphshshaYs..spR..shW........V-PhoGslVctpEchpcaaupsstp..........................chshhph.phphs--TlpptlstAcst..........pcp..lthhuchlPhshtslGllhLlsGhh...........................................	0	20	56	75
+11104	PF11272	DUF3072		Protein of unknown function (DUF3072)	Pollington J, Finn RD	anon	Pfam-B_3823 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.60	25.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.83	0.72	-4.31	13	81	2009-01-15 18:05:59	2008-08-14 16:19:39	3	4	79	0	40	88	5	56.90	53	46.16	CHANGED	NsEKDPc-WsTGDEPMTGAQASYL+TLsEpAG..EshsssLoKA-ASchIDcLpppsGR	.............hpKDPs-WsTGDEPMTGAQtSYL+TLuccAG....Eshss..sLTKA-ASc+IDcLpppoG+......	0	15	28	34
+11105	PF11273	DUF3073		Protein of unknown function (DUF3073)	Pollington J, Finn RD	anon	Pfam-B_3852 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	30.80	30.50	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.42	0.72	-3.44	29	430	2009-01-15 18:05:59	2008-08-14 16:25:40	3	1	424	0	111	261	50	67.00	49	84.81	CHANGED	GRGRAKAKQTKVAR-LKYpSPsTDhspLpREL..uG.........sspspssss-shsDc.st......................cpYuc.s-t.c	.GRGRAKAKQTKVARcLKYpSssTDh-pLpREL..uu........tstssp.sc.s.....-.-...s..hs..D.-.h.s-.................................tDcYsc.st..p......................	0	34	82	103
+11106	PF11274	DUF3074		Protein of unknown function (DUF3074)	Pollington J, Finn RD	anon	Pfam-B_3858 (release 23.0)	Domain	This eukaryotic family of proteins has no known function but appears to be part of the START superfamily.	27.50	27.50	27.50	27.50	27.30	27.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.31	0.71	-4.66	28	152	2012-10-02 19:24:03	2008-08-14 16:30:32	3	2	107	0	125	153	0	197.00	26	41.03	CHANGED	WhuR+SlHc..................uhsapcacptLpsp.......+s-sEcpa.............lcslsutchlpph..................tst.spsphplhplpapFPh..sho...sRsFsslllshchs.................................ptsscpahllShPlsc....................pss.tpshlpGpYtSVEhlp.hs.................................................................................tpssslEWhMsTpSDsGG..slP+Whpcp....uhPpuIspDlstFLcWs	..........................................................WhuR+SlHc..................shsapcappsLppp.........+s-sEppa.......................htslsuhcplpph..........................................tssphplhplpaphsh.....shssRsFssLllosphs...................................ts.cpahllShPhpt.........................................ts.s.ppshlhGpYtSVEhlcpl........................................................................................................................................tpsstlEWhMsTpSDsGG...slPcaltcp....uhPsuIspDsshFlpWh.................................	0	33	68	106
+11107	PF11275	DUF3077		Protein of unknown function (DUF3077)	Pollington J, Finn RD	anon	Pfam-B_3820 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.61	0.72	-4.02	19	142	2009-01-15 18:05:59	2008-08-14 17:03:34	3	1	33	0	59	171	1	73.60	36	84.52	CHANGED	TsGtssFhpttt.pst.sLFRlpPGlPhpcAh-puShLhGhl+cLThcu.M...-sc.hhhhAu+YLSuMAKALhDDhElGhp	................t.Fh...t...tt..sLFplpsGlPhccAhppAStLhssspcLshcuhh....cs.ppp.hha....AuhaLutMAKALlDDhths........................	0	0	0	15
+11108	PF11276	DUF3078		Protein of unknown function (DUF3078)	Pollington J, Finn RD	anon	Pfam-B_3846 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	29.80	28.90	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.09	0.72	-3.81	36	294	2012-10-03 17:14:37	2008-08-14 17:08:44	3	2	198	0	84	291	141	93.90	33	25.50	CHANGED	hsQsuFs.NWtuGGsssluus...hslshptNYc.+cchpWcNplphpaGlsptc..spc.......h+KosDplclsSphGh..c.ttspWYYShhhsF+TQFssGY	..............hsQstho.NWh.tGGps.shuhh...sslshptNYp...+p+htW-NplphchGhspspucs........................h+posDtlplsSphGh...p..ssppWYYohthpFpTQFssGY...............	0	31	75	84
+11109	PF11277	Med24_N		Mediator complex subunit 24 N-terminal	Coggill P	anon	manual	Domain	This subunit of the Mediator complex appears to be conserved only from insects to humans. It is essential for correct retinal development in fish.  Subunit composition of the mediator contributes to the control of differentiation in the vertebrate CNS as there are divergent functions of the mediator subunits Crsp34/Med27, Trap100/Med24, and Crsp150/Med14 [2].	25.00	25.00	25.80	28.00	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	990	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.89	0.70	-13.65	0.70	-7.05	6	199	2009-01-15 18:05:59	2008-08-14 17:12:07	3	4	83	0	82	183	0	558.40	40	94.03	CHANGED	hKsspLKQhILpAWKERWoDhQWuINlKKhhP+GVohDlhNLA-ALLpQAhIGsusNPLlLSYLKaulsuphVSauuVLssISKaDcFsRchClpALLEhh-.hsDsloC+GKuEEsI.Ls+AhlShVaWLLQhhstss-+hp-st-h..ssttEphLptshpsL-+llpSsh.hullaIuKhEEsp.asslccphLclsp.lss...........lsssplcsphccssoL.psh.pMhslcucpl.cshhsolpsLIhlEshhN.ssDTQ.hVtQLhhlKRhp+hPhshhhhEIh+AChluL.pss-socEhhWsAFTFlKlPQlLtpL+thspstp.pD.......ao.DVspAFEhLLp.TPLLDhhDp+CsCsslphLLpEhsKhtLLoEspscpLsAKRsu...hsspLKps-.Nus.pP.NsshILRAEPslosILKTlsuDaSKs.EuLLGVLsphLSGpSLDLlLusAuspGKLKoFsp+hIphNEaoKp.lsGEhuKsAslRAhLFDlSFLMLsalsQTYGSEVILSEuusS....FFEpWlpsCMsEcsKshNPcp.shp.sDssKVEpLlshLNsSs....phKhsphKWcElCLoIPAslhcVL.AWENtsLSstsIpKIhDNIKu+lCShAVCAsuWLsAahpMlt.DEp.KPhsMIpQLsoPlsu...EphhQ..ah+ERlslMspIlc+MptDVhppsssp.Khtsth.p.....ppLsu+tPlcEthc-sa+sVLEKGWlss+uhahL-oLLphGGsaWhsspLVccLL+pphhcchsRsh-llaAIhpLDhppsTlsLLuallPhLLhcpuphcslsDP.uRsLAKLsVaChloohpop.tstsSutptp++RpchcDhspL.sLDshpsSthMRhl.....ussp--sshhuusGsc.....uhsSShSASpL+s........lsh+EPLppsLtsLFhlhSphluocphuP+s.FV.pFlp.hVEsucp.phuslLphhP.uhVppLlKlsuhsc.KV..lLplhDLslPhGRphAspsls	.............................................................................................................................................................h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	26	32	56
+11110	PF11278	DUF3079		Protein of unknown function (DUF3079)	Pollington J, Finn RD	anon	Pfam-B_3866 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	21.50	21.50	24.90	42.80	20.70	19.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.91	0.72	-4.42	10	130	2009-01-15 18:05:59	2008-08-15 10:29:55	3	1	129	0	38	95	4	50.40	70	69.48	CHANGED	MAKKFPLHPuHPERICWGCDRYCuADALACGNGS-RTQHPsELFG-DWhtau	....MAKKFPLHPpHPERICWGCD+YCssDuLuCGNGSsRTQHPsELhG-DWYch....	0	5	18	29
+11111	PF11279	DUF3080		Protein of unknown function (DUF3080)	Pollington J, Finn RD	anon	Pfam-B_3870 (release 23.0)	Family	Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently this family has no known function.	25.00	25.00	48.50	48.30	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.10	0.70	-5.28	24	161	2009-01-15 18:05:59	2008-08-15 10:30:32	3	1	160	0	29	132	67	301.60	36	90.76	CHANGED	hhcsYhpRLAslLDss...s.sh.shsshsl...Ps+Rp....hhhslsclsluLL-h.hpLppC.pLtpLIuE+NS.LGKVtsshpchpYphphlpuhppCl......p.t.tspslpspLpphhppKpppLshthhNslhsscphcpthohusphLshst.tsphuchhsAlpplsthhtt.........tttpsphssppltph.cpLpppchhGpLhhShpptsthLsssTphLppp.stpslCssspssschphLpNlFhphYltplQPYlApLspthppLts.ltpltpphs.h...hss.hptah................................sshappa+pustpHVphWQpLacpC..uhssu	........s.F-cYlpRlANV.pts................shs.ss..hss.sL.......PcKR-....Lhls.lssloIuLLDu.YpLRpC.uLFpLIAERNShLGKVQDthpcacYQlsLLpulpsCL..................ss..splspsL+spLhslps.KpppLsspaaNhLasS-shRpQLo.uopahstph....shu-ll.ALcpLsslppp.................hhsp...pslsopsLs..stQEsLcKp+llGclhaSLspuosaLcssTptLcsp.sssllCusp+ss........s+hpYL+NVFpp.YlcclQPYLApLDptYhQLsstLshhpp.ps.....hs......................................hpssappFRhAsppHspaWQpLFtRCtlslG...........	0	7	14	23
+11112	PF11280	DUF3081		Protein of unknown function (DUF3081)	Pollington J, Finn RD	anon	Pfam-B_3884 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	64.20	64.10	22.50	19.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.60	0.72	-4.45	22	143	2009-01-15 18:05:59	2008-08-15 10:44:01	3	1	139	0	27	89	11	79.40	54	89.94	CHANGED	cl-hpphLpla-pIpppGcp..p-st.....YhhpGlpAapDaDGYTlaLpspsVsLslhFHNoYcl-Y..................-pccphspFh++lpslh	...L-ssKlLpAYEsVMpNGoP....TEaG.....KlYEGIEAauDYDGYNlahRGNGVELKlGFHNTYHLsY..................EQEHL+DSFLKKLuhL.A..	0	6	15	22
+11113	PF11281	DUF3083		Protein of unknown function (DUF3083)	Pollington J, Finn RD	anon	Pfam-B_3898 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	21.00	21.00	22.70	22.40	19.80	17.00	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.09	0.70	-5.31	12	45	2009-09-11 05:40:26	2008-08-15 10:44:43	3	1	40	0	16	36	16	301.00	55	87.65	CHANGED	ssYQpLSctlFpLsEcc-LpNlHlIANDKLPhVRapsEuYshpTscQllFFYNPtYHEupphahsssh+A+KlRllFLATG--lRuNSApFHp+VpphlpcLtspLslpp.plKlRDHQHLoYDlFAKuKGsKpoYGaKLRuIssRYpuRpCsLPpsaouloYsTlslPlsR+l+ppl.sp.psp-.assLYpplpDsFhpAspsppLs+sAMlANGlsPlVRNSch-plssssElQMlGFDPptppsphls+WsuscLV-olpFllsAuppDps-tGaGRFhNpVEpAl+shss-lsl-tp+p-lhlRFHQHISYp	......................sCYQsLSRhlFsLu-pa-L+NVHVIsNDKLPVVRaHsEAYChpTsEQlLFFYNPtYHEAppLasp-saRARKlRIlFLATG-DIRuNSAsFHh+VpclLscLhspLPlpp.plKlRDHQHLoYDLFAKuKGsKEoYGYKLRuIsPRY+ARpCpLPcshuuLTYVTVoLPLSR+LKptlhs-.sssD.FsPLYQ+LpDsFlcAsss+pLs+lA....MlANGLTPLVRNSKa-+l-upsElQMlGFDPsssEpQllp+W-uspLVEssHFsIVAuscDpcDtGaGRFMNpVEsAL+sFssElulD.-R-DLlVRFHQHISYp................	0	4	6	10
+11114	PF11282	DUF3082		Protein of unknown function (DUF3082)	Pollington J, Finn RD	anon	Pfam-B_3896 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	25.90	25.60	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.65	0.72	-3.92	20	104	2009-01-15 18:05:59	2008-08-15 10:45:45	3	1	98	0	52	104	104	81.20	36	44.12	CHANGED	cpuPLshLSGuloSuhlualsahLopplsshFAt+PsphSsslsQsIuoAl+TLllGhshLATFsFAFlulGLhllhlpsLh	...............................sPlpsLhGulhuusluhhhYtLosslsssFut+sls...s.s.h.sppIusslRTLlhGlshLATFlFuhlulGLhllslQlhh......	0	13	36	48
+11115	PF11283	DUF3084		Protein of unknown function (DUF3084)	Pollington J, Finn RD	anon	Pfam-B_3912 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	50.80	49.90	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.63	0.72	-4.12	16	146	2009-01-15 18:05:59	2008-08-15 11:08:44	3	3	145	0	52	150	102	78.60	44	18.38	CHANGED	uGalLIlulLlLGGlIATlGDRLGoKVGKARLSlFsLRP+pTAVLlTllTGolISAhTLulLhssS+pLRpGlFpl.-pI	.....ualLllslllLGGlIAhlGD+lGo+lGKpRLoLFsLRP+pTAlllTllTGslIuuhT.lullhhsScslRpuLFph-p........	0	16	36	50
+11116	PF11284	DUF3085		Protein of unknown function (DUF3085)	Pollington J, Finn RD	anon	Pfam-B_3922 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	25.10	25.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.92	0.72	-3.79	24	126	2009-01-15 18:05:59	2008-08-15 11:13:49	3	1	107	0	43	108	2	88.70	37	66.35	CHANGED	sslhLVtDcGVYlhusst..hs..sGp...hlsYApGCsPcts..--WachtRpthGGDDhsEhl-s..shlpphlpss.c...Lplphossplplhs	...stllLVKDpGVYlhuptu.cts......sGp.....hlAYAtGCsPcsD...--Wa-hucpphGGDD..FuEhlcs..shhppllpssts...Lhlph.osoplplt.s.........	0	4	22	34
+11117	PF11285	DUF3086		Protein of unknown function (DUF3086)	Pollington J, Finn RD	anon	Pfam-B_3929 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	23.60	23.60	24.20	96.50	23.00	23.50	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-5.59	18	73	2009-01-15 18:05:59	2008-08-15 11:19:56	3	2	71	0	28	88	163	274.90	53	76.67	CHANGED	llplALp-LppRRpuLptEIEcLEpRKcplEpEl+ooFuGpSDsIA+RVKGFQDYLsGALQDLApSsEQLELVsQsshVpPSPLD....ppusssssss......tssssusupsFps-pcLIRptLppapppPDaYAsPWpLRRSlEshcsEhl-DWFFNQGGRGA..ShGSR.+NlLVuuAlIuILu-LYGDpFQsLVLAupPERLGEWRRGLQDsLGLuREDFGPsSGIVLFERuDALlERADRLEEcGElPLIlIDsAEcsV-lslLQFPLWLAFAusPp..Ehhp--c	..................................lp-uLp-LppR+psLphplEpLE+R+ccIcpEh+ooFAGtSpslAhRVpGFpDYLsGuLQDLutuAEQLELls..psshhpPu..Phs...........................ptttsstt............ssss.hsspsFpsppchI+phL-papppPDaYusPWpLRRohEshcsEhlpsWFFsQGGRGAlpShGSR.pNlLluSAlISILscLYGDchpsLlLAssPERLGEWRRGLQDsLGluRpDFGPspGIVLFEps-ALlp+ADRL.ccsplPLIlIDsuEcplslslLQFPLWLAFAssPpph.p..t...........................	0	3	18	26
+11118	PF11286	DUF3087		Protein of unknown function (DUF3087)	Pollington J, Finn RD	anon	Pfam-B_3938 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	22.60	22.60	22.70	22.80	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.82	0.71	-5.01	25	105	2009-01-15 18:05:59	2008-08-15 11:24:09	3	1	103	0	37	106	10	163.40	38	96.62	CHANGED	MpLppIDKppYR+phNhlhlshlusLslLSLshushLIuLFG.................stusuNF+aNLlGVlluhllsuslLp.ph+s+saMpElhYVWcLKQhhN+IhRKL++lKsAAspsD...hsAlhlLpFYYsu.+QlapLDsNTlTlsslpp-lspLppthtphuLslstcpa-sphL	..MpLppIsKphYR+phNhlhlshlssLslhSLshushLIsLFG.................spusuNFHhNLlGVllulhhssullp.plKs+PaMpElhYVWcLKQhhN+IaRKlpplKAAAp.psD...ssALhhLpFYYsu.+QlapLDsNTlTh.s.sls..p-hspLpphhtphuLsLshspacsshL..............	0	4	14	26
+11119	PF11287	DUF3088		Protein of unknown function (DUF3088)	Pollington J, Finn RD	anon	Pfam-B_3952 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	30.90	64.70	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.28	0.71	-4.61	19	111	2009-01-15 18:05:59	2008-08-15 11:28:02	3	1	87	0	36	105	3	111.40	45	85.00	CHANGED	s+DhLFLLcPGFtDsut.PGt.FaCscssslEGLLusaPsLtsplDVc+lsasRPRtslltLlG-spQSlPVLlLusspssssss...tstsspRFlsDsccIhchLupRaGhPcs	...........+DhLFLLcPGFtDstp.Ps..FhCsculslEGLLushPsLpsplDVc+lsasRPRcsllAhlGEscQShPVLVLus..stss...ssu...pshsspRFlsssccIhchLuppaGhs+.h...............	0	10	17	28
+11120	PF11288	DUF3089		Protein of unknown function (DUF3089)	Pollington J, Finn RD	anon	Pfam-B_3953 (release 23.0)	Domain	This family of proteins has no known function but appears to have an alpha/beta hydrolase domain and so is likely to be enzymatic.	23.40	23.40	23.40	23.60	22.80	23.30	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.58	0.70	-5.17	25	100	2012-10-03 11:45:05	2008-08-15 11:32:33	3	2	78	0	52	106	398	198.30	29	55.10	CHANGED	tssVFaVaPToa...hstu..tWNuslsssps...thtchhltspAusF.spssclaAP+YRQAoltAa.....h.sspsp..ustA...hchAYsDVtcAFctaLsphssuRPllLAGHSQGuhhLhcLL+ccIuGcP.lpcRllAAYlIGhs.lsl...-ts.sshtslPsCpsssQsGClloasoa..t........ttt..s.su.c..upsts.spphlCsNPlshsssss	.............sDVFalaPTs....h......ssss......h..Ns....sl...ssttt..tthspthlttpAusF.ssssplaAPhYRQssltsh...................h.tttss......spps.....hp.hA.YsDVtpAFchYLpph.NpG.RPhILAGHSQGuhhlhcL.L+..c...phssps.lpcRlVAAYllGhs.lss.....pth.tth.slshspssspoGClloasoh...s........................s.t..ths...........ttthhChNPhshtss.s......................................	0	23	42	45
+11121	PF11289	DUF3092		Protein of unknown function (DUF3092)	Pollington J, Finn RD	anon	Pfam-B_3988 (release 23.0)	Family	This viral family of proteins has no known function.	18.70	18.70	20.00	19.80	17.60	17.50	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.92	0.70	-5.18	4	77	2009-01-15 18:05:59	2008-08-15 13:33:13	3	1	69	0	0	37	0	267.00	88	99.20	CHANGED	MDLFMSIFTLGuITRQPuKIENASPASTVHATATIPLQAShPFGWLVlGVALLAVFQSASKVIALHKRWQLALYKGlQLVCNLLLLFVTIYSHLLLLAAGMEAQFLYIYALIYILQIlSFCRFIMRCWLCWKC+SKNPLLYDANYFVCWHTpNYDYCIPYNSVTDTIVlTSGDGhopPKLKEDYQIGGYSEDWHSGVKDYVVlHGYFTEVYYQLESTQloTDTGhENATFFIasKLVKDsspVQIHTIDGSSGVVNPAMDPIYDEPTTTTSVP	................MDLFMRFFTLGSITAQPVKIDNASPASTVHATATIPLQASLPFGWLVIGVAFLAVFQSATKIIALNKRWQLALYKGFQFICNLLLLFVTIYSHLLLVAAGMEAQFLYLYALIYFLQCINACRIIMRCWLCWKCKSKNPLLYDANYFVCWHTHNYDYCIPYNSVTDTIVVTEGD.GISTPKLKEDYQIGGYSEDRHSGVKDYVVVHGYFTEVYYQLESTQITTDTGIENATFFIFNKLV.KDPPNVQIHTIDGSSGVANPAMDPIYDEPTTTTSVP...................................	0	0	0	0
+11122	PF11290	DUF3090		Protein of unknown function (DUF3090)	Pollington J, Finn RD	anon	Pfam-B_3954 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	19.50	19.50	19.70	19.70	19.00	19.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.18	0.71	-4.79	15	303	2009-01-15 18:05:59	2008-08-15 13:34:29	3	1	301	0	84	177	117	172.20	51	88.62	CHANGED	asFDsP-RFVsGTVG.PGsRTFaLQARsGuRlVSVuLEKsQVulLAE+ls-LLDElsR+tG..sslPss.ssshsDscPL-tPl-EEFRVGThuLuWDscsppVVIEshuls-..............-sDsc....shs-ss-ssDsLRVhLssssARAFAcRApcVVuAGRPsCPLCGpP.LDPcGHlC	........hacpPDRFVsGTVGQPGsRoFaLQA.tc.s.uRVVSVhlEKpQVshLA-+lspLL-Elsp+hG..s.VPPs.ssp.hcDLu..PLcs...Pl..-tEFRVGTMuLuWDsEspplllEh..hAlo-s.................thDsu........llhs-sEpuPD.ulRVhlTsppARpFusRuppVVu.AGRPsCPLCupP.LDPE.GHlC....................	2	30	66	80
+11123	PF11291	DUF3091		Protein of unknown function (DUF3091)	Pollington J, Finn RD	anon	Pfam-B_3979 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	31.00	31.00	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.25	0.72	-4.05	11	57	2009-09-11 07:39:49	2008-08-15 13:35:06	3	1	1	0	0	77	0	93.00	33	58.13	CHANGED	IcpLp-EIc+DYssaSccslEclp+ppspLcphasp.pSctpNhTCs+PcNIstcDlpsLpshItcpppshhshshacL++caLhplpcsLpNsscc.SE	........hcphccEIc+cYssasccVhEclhppsspLcphasphQSctpshTCs...........cPcNIstc.DlssLpshItp.phshh.hshhpLcpphh.plhcphpN.spp.u..............	0	0	0	0
+11124	PF11292	DUF3093		Protein of unknown function (DUF3093)	Pollington J, Finn RD	anon	Pfam-B_4007 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria. Some members are annotated as alanine rich membrane proteins however this cannot be confirmed.	21.30	21.30	21.30	22.20	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.73	0.71	-4.39	23	347	2009-01-15 18:05:59	2008-08-15 13:41:23	3	2	338	0	90	226	64	143.40	38	85.77	CHANGED	shYcERLWsPhWWWlhushl...sulhAh.lshus.slhsh.lshAllhslusslhLhh.....upscIcV.......ssspLhsGcA+LPsshlucstslsssstputhGppLDstAallhRuWlsshVhlsLsDPsDPTPYWLlSTR+P-cLluALp	......................hYpERL..WsPhh..WWlluhul...hALh..sh.shh.uhs.u.Lssh.lshsll.ssl..ssssllth.....Gp..s+IpV.......ssttLhsGcAplPhshluRstsls.upstpushGpphDsuAFllpRsWltshlhlhLsDPsDPTPYWlVSTR+Pc+LhuAl.....................................	0	26	66	86
+11125	PF11293	DUF3094		Protein of unknown function (DUF3094)	Pollington J, Finn RD	anon	Pfam-B_4017 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	20.90	20.90	20.90	21.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.57	0.72	-4.50	13	47	2009-01-15 18:05:59	2008-08-15 14:02:50	3	1	47	\N	13	42	25	53.60	58	92.01	CHANGED	oSRLSPEDQp+V-pYLuuPQHQVERpPFRPWhLhllVLAVsIGLGLLSRLLShLs	..oSRLsPEDQp+V-pYLpuPhHQVERtPFRPWhLhhllLAVVIGLGLLSRLLShLs......	0	1	5	9
+11126	PF11294	DUF3095		Protein of unknown function (DUF3095)	Pollington J, Finn RD	anon	Pfam-B_4020 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as adenylyl cyclase however this cannot be confirmed. Currently no function is known.	20.40	20.40	23.20	22.50	18.00	17.30	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.20	0.70	-5.43	25	117	2009-01-15 18:05:59	2008-08-15 14:20:26	3	2	97	0	48	132	14	331.50	38	95.68	CHANGED	FYssLPs..hstFpplsDsstYpPLP-DWslsluDIVsSTtAIusGRYKsVNMsGAusIuAlhNuh....ssh-hPFVFGGDGAshAVPsshhcpuRpALussptascp-asLsLRlulVPVuslRspGh-V+VARausSsslsYAMFuGGGLuWAEsphK.......sucatlssssssst.PDLoGLSCRWspI..PucpGpIlSlllhPsssssstsattlhccllshs-p...sscuuHPls.ps.plphsspuLshEA...RhptG.....t.hhhppltllh.slhuhlhh+p....shphssasscpYhpplspNoDFRKaDDuL+MslDsss-ptcplcshLppupspGhl+YGLHtQspAlMTChVsoshpccHlHFlDGAsGGYAtAAppLKs	....................Fattlsh..hptF.ptlhDss.YpsLP-sWhlulsDIVsSTtAIupGRYKsVNhsGAusIuAlhNuh......sthchP..FVFGGDGAshAlPsshhttAcpALussttasppphsLpLRsulVPVsslRspGhDl+lARatsStphsaAMFsG....GGlsaAEtthK.......tupahl...sss.sst.PDLoGLSCRWssl..suppGtllSlllhPsssssstthttlhpcllshhct....p.ctu+Pl.st.p...t.thphs...p..slthEu......+stts......h..hh...hthhhlhhtshhhhhhhph....th...hsth..s..sppYhpplstsoDFRKaDDuL+hslDssspphpplpthLptutttGhhpYGlHppspAlMTChVsssh.pcHlHFlDGAsGGYAhAAttLK............	0	9	22	27
+11127	PF11295	DUF3096		Protein of unknown function (DUF3096)	Pollington J, Finn RD	anon	Pfam-B_4028 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	20.70	20.70	21.00	20.90	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.73	0.72	-4.45	19	138	2009-01-15 18:05:59	2008-08-15 14:25:07	3	2	126	0	65	135	5	38.60	59	76.26	CHANGED	PlluLIAGILILlhPRLLNalVAlYLIllGLlGLhshth	.....PlluLIAGILILlhPRLLNYIVAlYLIllGllGLhsh..h.....	0	12	33	47
+11128	PF11296	DUF3097		Protein of unknown function (DUF3097)	Pollington J, Finn RD	anon	Pfam-B_4031 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	46.70	46.60	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.73	0.70	-5.38	18	374	2009-01-15 18:05:59	2008-08-15 14:29:13	3	2	369	0	98	278	7	265.80	56	95.51	CHANGED	DcYG.pDVLAsstRsttht...ss-lPsEhGlVVE-suoGFsGAVVpsEput....VpLEDR+G+pRsFPLusG.FLl-GpPVsLstP..tsusAp.......PsR..TASGSlsVtutcARVApASRIaVEGpHDAELVE+VWG-DLRlEGVVVEaLcGVDDLsuhlAcFpPGPGRRlGVLVDHLVsGSKEoRIA-uVst.....sHVLVsGHPYlDIWQAVKPpplGlcuWPsVPRGp-WKpGlCptLGW.tu-pAD...uWpRlLupVcSapDLEPsLLGtVEcLIDFVTs	..............YutDlLu........st.......h..Rp......p..................ss-hPsEhGhVVEDss....oGFVGAVVthEpuh....VsLEDR+G+pRsFPluPG.FhlDGpPVsLstP....pt..usAu......................pR..TASGSlAVsutcARVAtsSRIaVEG+HDAELVE+VWGcDLRlEGVVVEaLsGlDDLsslVA-FpPGPGRRLGVLVDHLVsGSKEoRlA.-p.Vpp.....spaVLVsGHPalDIWQAVKPpRlGlpsWPcVPhspDWKpGlCctLGWPtu......stuD...uW.p+lLupV+sa+DL-PsLlGcVEcLIDFVTt.................	0	30	74	94
+11129	PF11297	DUF3098		Protein of unknown function (DUF3098)	Pollington J, Finn RD	anon	Pfam-B_4061 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	29.70	28.00	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.27	0.72	-4.26	28	232	2009-01-15 18:05:59	2008-08-15 14:34:55	3	1	213	0	70	203	188	67.00	45	81.64	CHANGED	hsFsKpNYlllhIGhslIAlGFhlMuGtsSss......tlauah+lplAPhlllhGasl.laAILhpP+	......hsFsKpNallLsIGhAllllGFlLMoG.......suSs.......-.ssF.p.s.-.IFShRRI+lAPlVsllGFlhhI.YAILh+P+...	0	28	55	67
+11130	PF11298	DUF3099		Protein of unknown function (DUF3099)	Pollington J, Finn RD	anon	Pfam-B_4064 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	23.20	23.20	23.40	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.61	0.72	-4.23	24	391	2009-01-15 18:05:59	2008-08-15 14:43:59	3	2	356	0	114	278	53	69.10	35	54.99	CHANGED	hITsAstohp--h+sRh++YslhMulRhssllLAslsh.....ualpllhls..sulsLPWlAVllAN.spssppppcs	...........hITsA.t.u.t.phct.R...+cYhhhMulRsssllhA.slsh.h.....shl.ulshls..sulsLPalAVllAN.sts.+psp..t............	0	34	89	109
+11131	PF11299	DUF3100		Protein of unknown function (DUF3100)	Pollington J, Finn RD	anon	Pfam-B_4068 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	20.20	20.20	21.80	22.80	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.52	0.70	-5.15	27	247	2009-01-15 18:05:59	2008-08-15 14:51:52	3	1	215	0	74	233	4	231.70	44	74.12	CHANGED	llluE.hIGshplslGsu.sllLLPhlaAlllGhhlshthh........phlsccptphAusllhlulh.LlA+hGsslGPsl.pllsAGPALlLQEhGpl.GTllluLPlA.llLGh+REuIGATaSIuREPslAlIu-KYGhcSPEG+GVLulYlhGTlFGslFholLAuhlushsh.FcPhALAMuuGVGSGSMMuAusGuLsuth.P.chscpIhAaAuASNLlosssGhYhslFluLPLsphhYphl	..................lluE.hIGhhphslG.u.pllLLPhlaAlllGhhlu.hthh........phlsccphphAuslltlulhhhhAKhGhslGsslspllpuG.........ALllQEhGpl.GTllluLPlA.llLGl+REAIGATaSluREPslAlIu-+YGh-SPEG+GVLuhYlsGTlFGslahullAuhluu.hsh.FcPhALAMuoGVGSuSMMuAAsuuLsshh...P.-...hucp.lhAhAAASNLloshhGhYhslFluLPLspahYch....	0	23	50	62
+11132	PF11300	DUF3102		Protein of unknown function (DUF3102)	Pollington J, Finn RD	anon	Pfam-B_4016 (release 23.0)	Family	This family of proteins has no known function.	20.10	20.10	20.10	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.57	0.71	-4.12	14	260	2009-01-15 18:05:59	2008-08-15 15:05:59	3	5	129	0	69	230	14	117.60	29	44.05	CHANGED	RTPhlIAuEINhI+cQopKhLLtsAlEIGRRLpEAKuLlPHGEWhcWLcESVuYSppTAspLMplacEYGphh................so.ssp-u..N..............ttshssLsYTQALlLL...GlPEEER-pFls-pDVps.MopRELpQAVcE+	................................EIp.h.pp....stp....hh.shlEIG+RLtcsK.....p.h.l..sHG.....-atcWLcpplsaSppoAp+hMplhcca.us.....................t...........t.........................t.h.pL.hppslh.Ll........sl..s-t.-c...phh........t..................-........l.tp...Moh+ELptslpp...................................................................................................	0	28	52	58
+11133	PF11301	DUF3103		Protein of unknown function (DUF3103)	Pollington J, Finn RD	anon	Pfam-B_4046 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	25.00	25.00	30.40	29.20	22.30	19.70	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.08	0.70	-5.75	15	133	2009-01-15 18:05:59	2008-08-15 15:14:23	3	1	126	0	20	86	3	341.20	63	88.23	CHANGED	KRpLAhpLScpYsplcssLpppIsphpLssslspLlppstsss....h.pphppA-pslRphKGlssho-s...............LLplRLADssMLsuWQpGc.sPLFAFEPsGDDcsWpYIEAYDltGplHhLDVYplP-pPVhVVDssupc-l+AGLtsM+sEhs............t...sspp.phtstusts....ppt.spupspsIsTTlLKKIRLpDDpEPWISGKAEIYAIVTGVsPSRDEPsLDlVEMPYLDYDcpsYYPNQllIaWsRYRWGAADllLMEpDDGTNYKpLAphLlcAAEplLKsIPDPEVQGYAIIsQITscIIcslPDuhhTNDDDFVDVaYTLhpspsYsDHsGAuGNAssTFsPLTIsPT	...........................................................................................KRpLApphSpsYAshtpoLKoQIospsLSlslS-Llcs.sPss-......hSpQLppA.DpslRolKGIs..paT-p...............LLQLR..LADsoMLppWQpGp.SPLFAFEPS.G.sDcsWQYIEAYDVYGQIHQLDVYQLPDVPVFVVDsDSuhELKAGLQAMRAEMp+L..........ttssplsspcSs.uhcsuspo....hspuusu-ssPISTTVLKKIRLpDD+EPWISG+AEIYAlVTGVDPSRDcPTIDLl-MPYLDYDcQDYaPNQllIHWsRYRWGAADhILMEQDDGTDYK-LAKpLVcVAEEVLKhIPDPEVQGYAIIsQITuKII-AIPDGVLsNDDDFVDVFYTLMQDTpYsDHPGAsGNAsATFEPLTI.PT................................	0	3	5	12
+11134	PF11302	DUF3104		Protein of unknown function (DUF3104)	Pollington J, Finn RD	anon	Pfam-B_4053 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	20.00	20.00	20.00	22.10	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.34	0.72	-4.60	20	52	2009-09-10 14:59:42	2008-08-15 15:35:57	3	1	25	0	24	55	153	68.90	44	75.02	CHANGED	shFLuV+sGDhVlVpsss..tsspttpp.sWWMGpVlpspGG....ARsPpssoLFQVADVDoGhI+WVNADpVo+llhshc	.....PhFLtV+sGchVlVpppp..........t.sWaMupVlhspGG....ARsPcssoLFQVADVDoGhIpalNAD.Vo+Il.p..s......	1	1	7	14
+11135	PF11303	DUF3105		Protein of unknown function (DUF3105)	Pollington J, Finn RD	anon	Pfam-B_4062 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	25.00	25.00	25.20	38.20	23.40	24.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.80	0.71	-4.31	37	224	2009-01-15 18:05:59	2008-08-15 15:41:28	3	4	181	0	135	235	28	128.10	34	48.60	CHANGED	ssH...lpts..lsYs.....psPPsuGsHsshWhsCu..hY..spsl.sppsVHsLEHGAVhltYcPs.lsssplppLpphsps.ts............hsllSP.....hss.hssPlslsAWu+pLpl.css--splppFlppa.........hpuP..ptPEsuAsC	.....................t..H.hphs..lsYs.....psPPsuGsHss....hWtsCst.lY..spsl.sEphVHuLEHGAVhlsYcPs..hsssp...lppLpphlpu.ts.......................hhlhSP..........h.s.....cs..PlsLsuW...........G+p..............Lpl.cssc.....D...tclspFlppa............hpss..phPE.su.C............................................	0	43	90	126
+11136	PF11304	DUF3106		Protein of unknown function (DUF3106)	Pollington J, Finn RD	anon	Pfam-B_4069 (release 23.0)	Family	Some members in this family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently no function is known.	23.10	23.10	23.10	23.70	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.83	0.72	-3.63	30	277	2009-01-15 18:05:59	2008-08-15 15:48:36	3	2	230	0	106	262	41	94.00	27	48.62	CHANGED	sWscLossQppsL.uPLupcWss.hsstp+c+WlplAppasphoP--Qp+hppRMpcWspLoscQRppARpsapph+pLs....Ppp+p...ppWctYQpLssEc+ctLAtpt	...........................WtpLs..pp.hL.tsht.pWst.hs...p+p..+hh.p.hutca.phoPppppc.hptRhs.cWtphoP-pRctsRpp.ap.p.h.+pLs....spp+p......ppap.ta.ppLs.tp+pthtt..t.....................	0	26	67	86
+11137	PF11305	DUF3107		Protein of unknown function (DUF3107)	Pollington J, Finn RD	anon	Pfam-B_3881 (release 23.0)	Family	Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	21.00	21.00	21.00	25.60	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.37	0.72	-4.10	26	426	2009-01-15 18:05:59	2008-08-15 15:52:41	3	1	423	0	109	263	78	73.40	43	94.06	CHANGED	MElKIGlpsssRELslpSsQos-EVpphVu-ALssss.GlLsLoD-KGR+hlVPssplAYVEIGssssR+VGFus	.MElKIGlpsusRElslsos......p...os-..-lcptlspALuss.s....ulLs.LTDcKGR+hLlPuspIAYVElGss.ssRpVGFG.......	0	33	80	101
+11138	PF11306	DUF3108		Protein of unknown function (DUF3108)	Pollington J, Finn RD	anon	Pfam-B_3856 (release 23.0)	Family	This is a bacterial family of putative lipoproteins. The structure for Swiss:Q64U78, PDB:3fzx, the first structural template for this large family including several homologues in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Swiss:Q64U78 is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localisation for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit PDB:2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	27.00	27.00	27.00	27.10	26.80	26.60	hmmbuild  --amino -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.52	0.70	-4.71	135	1119	2009-01-15 18:05:59	2008-08-15 15:57:36	3	3	918	1	417	1035	746	234.00	15	85.25	CHANGED	hlshhssssssusps........................................................stphpYplph.tsh.....thu...pushph......hpss....ttaphpspspssul.......h..hptthts....hhhst.tth....stpattptppsshppptp..hpFshp.ptpsh.................hptt.tp.sh.tsh...D..huthhhhphthtt.sh.........phshslhsscch.hphphph.........hup.Eplp.sstGp.hcslphp..................ttthhpp.ppshphWhu.......ss..hl.P.V+lcttt.........hG.shphpLsphp	........................................................................................................................h.......s..s...ttt..................................................................t................shphpYphph..tsh..........phu......pushph........tpss...................tsaplshp.sps.sth...................thhs...thth.ss..tslh...Ptpappptpt.tttpp.t.p....hpFshs.stpst................ttptpt.tphshtt.ssh.....Dh..hohhhpl.tt.htsssh.............shshtl....h.csc.ph..ph.p.hph.........hGp..Eplp..s.....s..s.G....p...hc..sl.....+hp.......................thhpp..ppp..hphW.hu........sshshl..P.V+lphhpt.......G.phph.l.t..t..........................................................................	0	129	280	358
+11139	PF11307	DUF3109		Protein of unknown function (DUF3109)	Pollington J, Finn RD	anon	Pfam-B_4077 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.90	20.90	22.80	20.90	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.26	0.71	-4.78	28	212	2009-01-15 18:05:59	2008-08-18 12:42:32	3	1	210	0	65	204	121	181.80	49	92.84	CHANGED	MlplGcslVSc-llcppFlCsLssCKGsCCVEG-hGAPLcpcEstlL-clhscV+shLpcculcsIccpGs.lpstpG-h.Tshl.su+ECsassatccGhshCuIEpAYppGhlsacKPlSCHLYPIRVp+hsshsAlNY-+WplCcsAppLGcEhpVPlYcFlKcALlR+aGcsWYp-Lcph	....................MlQlscslVS.DllcccFlCs..LssCKG...tCC.lEGDAGAPl-.-ElthLEclhstlh.s.Lsscutt.sI-cQGsshpD....p.-GD.lsTslV..s.s+-ClFssat-..........c.....G.....hshCAIE.+.A.Y.cpG.cscah.KPlSCHLYPI..Rlp..ca.s.s.ap.AlNYc.RWc.lCcsAsthG+chslPVY+FLKEPLIR+FGc-WYpELc..h..............................	0	23	50	62
+11140	PF11308	GHL1-3	DUF3111; GHL;	Glycosyl hydrolases related to GH101 family, GHL1-GHL3	Pollington J, Finn RD, Naumoff D	anon	Pfam-B_4091 (release 23.0)	Family	This family of bacterial and lower eukaryote glycosyl hydrolases is related to CAZy family GH101, and is made up of sub-families GHL1-GHL3. In the example Swiss:C02A26, the substrate-binding Asp is residue 596, the nucleophilic Asp is residue 706, and the proton donor Glu is residue 747.	25.60	25.60	25.60	28.20	23.40	24.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.10	0.70	-5.09	24	306	2012-10-03 05:44:19	2008-08-18 13:05:20	3	2	258	0	36	239	5	281.20	36	43.87	CHANGED	sLpp.hGlc+halth.DsWttuha...pP-hlssuccuG................YLhusaDpYtshh....pDtahsAp......htcptulpptDGohhtthp..usGhhh...sstshsaV+pphsclhp....ththsuhFLDV.uss.sp-sa........sscHhhscppshps+ptphpaltpc.sllhGSE-GsshsspslsFsH.........asst-hhtpcpus.ahG........hP...........................lPLYphVaHDslIs..........s.........Whhsp.ph.....ss.ppchhLhslLasssPhlphs.ts.hth....p.......htphhctpphhpshHcplsppchssachlststhlQ............pop	....................................hpp.sGlp+hWlGL.ssWt.uhh...pPphVspAcphG................YLlGsYDSYpohht.u.s.csW.TAph......ssphh-pssl.pptsGph.tGFh....upGhhLN.........P..s..hths.V+pRhpcIlp....hspaNShFlDsDuTu.hh-DY........pscc...hssppp.lpAt.pRhpalsp.p.shllGSEsGNshsspslsFAHGhpo.s.htWsDpcM+ps+pSsYYlGtaa....stthPth..ah.K.s.lKt.a+......plhhsP.YpVPLYphVapDplIo..........oa.......+Wt.solKh.....ps.hssR.LhthLaNsPPhhHLs.csphpp..........+.............hpplpca.psat.hHcphhccthssFpaLscpt.VQpo..............................................................................................................................................	0	16	23	29
+11141	PF11309	DUF3112		Protein of unknown function (DUF3112)	Pollington J, Finn RD	anon	Pfam-B_4107 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	23.30	23.30	23.80	23.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.06	0.71	-4.44	32	153	2009-01-15 18:05:59	2008-08-18 13:10:15	3	2	86	0	121	150	3	176.40	30	42.87	CHANGED	PhsG.pphFthhhhslYsllsslllh....llsusl..hYhLs.ptappt+plhhsuulhlhlashsslsllslua.hlPpp.......................h.IESFu.h...................................................phssphhllhhoolllhluuhh.......................RssssFp..........t.hsps.u.htutsshYlh.hshElllsllYllsRlDLRFY	.............PhhG.pphhthhhhslYhhlsssllh....llsusV.thahL.s..psh.pth+sl..hhuush.lhlhuhhslsllsluh.hh...Ppc..............................lEpFu..h.......................................................................phpsphhllhhoohLlhlGAsh.......................RssssFt..........p.hsps.uhhps+ssaYlh.aslEllVshhYhluRlDhRFa....................	0	25	60	105
+11142	PF11310	DUF3113		Protein of unknown function (DUF3113)	Pollington J, Finn RD	anon	Pfam-B_4134 (release 23.0)	Family	This family of proteins has no known function. It has a highly conserved sequence.	25.00	25.00	56.30	56.30	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.00	0.72	-4.29	3	239	2009-01-15 18:05:59	2008-08-18 13:28:53	3	1	165	0	3	60	0	59.70	73	98.36	CHANGED	MQQQAYINATIDIRIPTEVEYpHFDDVDKEKEsLADYLaNNPDELLKYDNIsIRslslEV	..MQQQAYINATIDIRIPTEVEYpaasDVDKEKEsLADYLaNNPsELLcYDslpIRslslEV	0	3	3	3
+11143	PF11311	DUF3114		Protein of unknown function (DUF3114)	Pollington J, Finn RD	anon	Pfam-B_4178 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as cytosolic proteins. This cannot be confirmed.	25.00	25.00	26.20	25.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.77	0.70	-5.02	10	265	2009-01-15 18:05:59	2008-08-18 13:51:55	3	3	200	0	27	196	0	253.50	36	72.05	CHANGED	lGSstFppLWpttptpsss....KLLphlLshlcMPpELoG-LccsppL.....lscFSs-LuP+csFW+phuplVQpAFPsssLop...psp..lp++lHQFRYlISoQQAQaVRcHa+..ptGMTDupALApYLpt.............p+.sssYshhESARLHNKht...h..cssphl.YPDspsp.h.....NhKlLlsFHoEFILDppGpFLNplDs....................EthopNGllNGASFNYus.........+....NsspHtpLDVcPsphaDPtFRccshcu....F+SP..........p.pchphuahspKuhY	..........................................................................lGSssapplaphpthp.pt...........clL..hhthlth..cLuuplcppthL......lt+FusslsPcssFWc.huphVppAaPspphup...................spp...hs+plHQhRYhIspQphpa..lRsa....a+.....ppGt...TDtpALttYlp..................t..shchshtpSuRLHNKh......h........ptphh.aP-sts..h........NhKl.h..s...F..H.oEFILs.pp.GpFlsphDs.............................ps.......pppsllNGsSFNYus...............p..........N.scpHp.LDl.sPs........t.......haDsphR+psh+s....ahS.P..................chp...h..........................................................	0	1	9	19
+11144	PF11312	DUF3115		Protein of unknown function (DUF3115)	Pollington J, Finn RD	anon	Pfam-B_4191 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.10	21.10	21.50	21.60	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.06	0.70	-5.57	20	129	2009-01-15 18:05:59	2008-08-18 13:57:06	3	3	119	0	96	125	2	302.80	36	84.10	CHANGED	LF+ssFpspL....................................tusc.......LpphlQsVKucLYNRDahuAFss..--hhtAYAsRWSPSRALuYuolFssLt...........phhp.lssstss...................................................s+VLCIGGGAGuELVALAula.........stsppttustsus.................................lslslVDIADWSsVVc+Lssslpos.....................h..........pscsFslsFtcsDlLshsps........................phhslhps................hsLlTLhFThNELFops.hucThcFL.+LospscsGoLLLlV-SsGSYSclplG..................pK+aPhpFLlDphLlussssp.......sssWEhlpppDSpWaRh-tp.....tlcYslt....LENMRF.h+LYR	.....................................................h.t.h.....s.tp.......lpphlQtlKspLYsRDa.sAFss..pphhtAYAhRWSPuRALuYuulFtp..l............chht.htsstt....s............................................................................................................tpVlClGGGAuuElVALAuhh....................pph.st...tt.......................................................tlslshlDIAsWusVVppLssslpot..................h.............p....spphsspFtppDlLphspt........................phhtl.ht......................t.sLlTLhFThNELFops.hscThpFLhpLss...htsGslLLll-SsGSYSplslG..........................................p++aPhpFLlDphLlustttp................Wch.l..pp-ShWaRhstp..........LcYslt.........LENMRa.h+LYR....................	0	15	45	81
+11145	PF11313	DUF3116		Protein of unknown function (DUF3116)	Pollington J, Finn RD	anon	Pfam-B_4194 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Bacillales.	23.20	23.20	23.30	23.80	22.90	23.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.72	0.72	-4.37	6	124	2012-10-04 14:01:12	2008-08-18 14:10:29	3	1	42	0	3	60	0	84.90	44	97.09	CHANGED	ME+ssccLlhpVL.hs+sssssIpcLohphlphssspsaTKNELLhslYWLEhpGYlpRsppssppR.YohTtcGchLLp+lpsph	.............................MEcPscpLIhpVLphscsssssIccLol.E.hlpFsslssaTKNELLaslYWLEppGFIhRs..sps..s..p.....pR...Yo.hTpKGchLLp+lcp..l.....	0	3	3	3
+11146	PF11314	DUF3117		Protein of unknown function (DUF3117)	Pollington J, Finn RD	anon	Pfam-B_4211 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	52.10	52.00	21.10	20.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.65	0.72	-4.44	9	364	2009-01-15 18:05:59	2008-08-18 14:14:43	3	1	361	0	92	169	30	50.70	73	87.12	CHANGED	MKPRTGDGPhEVTKEGRGIlMRVPLEGGGRLVVElsssEAtpLussLssVs	.MKPRTGDGPhEsTKEGRG.IVMRVPlEGGGRLVVELssDEAstLGstLKsV.......	0	32	75	88
+11147	PF11315	Med30		Mediator complex subunit 30	Coggill P	anon	Pfam-B_28118 (release 23.0)	Domain	Med30 is a metazoan-specific subunit of Mediator, having no homologues in yeasts.	25.70	25.70	30.10	28.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.89	0.71	-4.08	6	107	2009-01-15 18:05:59	2008-08-18 14:37:18	3	4	82	0	74	96	0	135.60	50	66.20	CHANGED	NslsLsRlGQETVQDIloRhhEl...FthL+shQhssssTpppusup-+huKlQEphRol+lLF++L.RllY-+Cs-.s.sshp.sslEsLIPYtsEshsph-sp.hutph+hllQE+cEllE....pV+tKNcQL+cIlD+hR.hlW-INoM..LuMpRs	..................NssoLCRlGQETVQDIV.RThEl...FQ..hL+shQ...lPNG.sT.ppsshpDRhsKlQ-pLRplplLF++L.RLlY-KCNEss....uGh-......h..ssE..........p..LIPYh-E.sts.+p.-sc....u...Rh.sspE++E..lhE......pl+.KNpQLKpIhDphRp.lIW-INsM..LshR..................................................................	1	24	30	52
+11148	PF11316	Rhamno_transf	DUF3118;	Putative rhamnosyl transferase 	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_4218 (release 23.0)	Family	Most members of this family are uncharacterised, but one is a putative side-chain-rhamnosyl transferase [1].	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.40	0.70	-5.16	30	99	2012-10-03 05:28:31	2008-08-18 14:48:30	3	4	64	0	36	148	27	203.30	22	69.03	CHANGED	pllGLCRFSYsu....hG.GFp....assh.tcRtAhLYAPsRL-cRFphFEslsLPSLtuQTD.-FphlllhGcshPcta+sRLccLstshP...Qh+lhhpsPtp.pRpsh+csl.ptsppsssssslQFRlDDDDAlulDFVtRlRpsspsh.slh..sppsplulDFs+Galh.phssc.Glsht.thpsahssuLuhhhps.ssppolhsasHc+lhpphP.slohsstsMalRshpspNDSppphstp	.......................................hhh.hRFsh.......s..................ttp.thhhs.thlp...pRhtlFEphsLPSlttQTs...s....FphllhhssshPt.hpp+Lpplh..tshs...phpl.h.......h....hs...sht....pt...p.....hhpphh....tt.............hh.....s..sss.hhphR..lDsDDAluhcFltpl+pth.t.th......tppp.hslsaspGhhh...t.t...s.......h....h...hhshhhuhh..............tt.......shht.h..s.Htph.phhs......hh......p..t.....shalpshpt.Nssp.....h................................................................................	0	15	32	33
+11149	PF11317	DUF3119		Protein of unknown function (DUF3119)	Pollington J, Finn RD	anon	Pfam-B_4223 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	30.70	30.20	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.72	0.71	-4.06	23	112	2009-01-15 18:05:59	2008-08-18 15:54:12	3	1	99	0	51	110	104	120.40	40	74.53	CHANGED	VpLsPSaplPlllllhulsLLhl....sW...sulllulFGLFLLlQohoLRLcFTscsL.VaRuscplR...........RFPYs-WlsWRlFWshlPsLFYFRElpS.....IHFLPILFDsppLcppLcp+sss	...........................V.lpPsaplPllllhluhsLhh....lp........h.....sul.sl.uLhGLFLLhQosplRlpFsss.sL-VhpusphlR........................RFPYspWhNWclF.........Ws..hPlLhYF+EspS............................IHFLPIlFsscpLpspL.c+ss.........................	0	14	36	48
+11150	PF11318	DUF3120		Protein of unknown function (DUF3120)	Pollington J, Finn RD	anon	Pfam-B_4230 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	27.60	134.60	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.65	0.71	-4.09	22	71	2009-01-15 18:05:59	2008-08-19 09:01:02	3	1	71	0	28	77	136	201.10	47	85.40	CHANGED	AuhLVslPVFlQAPWVRhpPhuuhLhThlllsluh.Lthhpppp.hthhGsLLlGFShSWLAGslaWGWLRhcPlhHLPVEAlALPlAlsGLps+W.+lGssFYLuSLlGTAhTDlhhhlTGlMshW.pVlpAs..spA..s.lLppAutplhpPhulshlhhhAsllltluphhhptup....p.psWuhuuAVL.oTLlVDuLFLlsAll	.AuFLVslPVFlQAPhVRhhPhhSllhThshlhlu..lhLhpp.sc.pthWG-LLlGFShSWLAGulYWGWLRhcPlhHLPlEAluLPhAlhGL.tppW.+lGshFYLGSLlGTAlTDlYhaLoGLMsaWRQlhps-..ss.A..s.lLpsAltpltTPhuluhsllLuhlLlhlGhhshp.pp.......ptchWuhuGAVL.oTllVDuLFhluAh....	0	4	18	26
+11151	PF11319	DUF3121		Protein of unknown function (DUF3121)	Pollington J, Finn RD	anon	Pfam-B_4233 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as phospholipase proteins however this cannot be confirmed. Currently this family has no known function.	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.11	0.71	-4.78	17	451	2009-01-15 18:05:59	2008-08-19 09:15:55	3	4	419	0	48	252	42	169.90	40	71.10	CHANGED	hstsppCpp.supLpRLuCFDplhsTPhphsttt.t......psstWpRAhspEtpRsscsshhhhppst.....ssshllTs.....................sAlG..ss..p.PlLhlSClssIoRlpLhLscslpps+Vplsl......t.sshsp.Whsc-sGhlLcuGRGLPAIcplKphluuppLplco.sssslDsLpFDhssLspulcPL	...................................................................................l.pthpsCRpEsusLERLsCYD+lh..s.P...hpssshssuhst..........................hutuWpRAhppE.p.cRpuss.s.tlLlTps.Gc...tsollITo.....................PAlG.....psss+.PV.LhhSClDNITRhpl.....AL...+..s..l..c..s....pcIsV..ol......cpRslcspWh..l.R.-sGsLL-SuRGLsuI-pIKpLhuucpLhlco..sssuAspLTFslcGLscAlsPL.....................................................................	0	12	22	34
+11152	PF11320	DUF3122		Protein of unknown function (DUF3122)	Pollington J, Finn RD	anon	Pfam-B_4242 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	25.00	25.00	32.80	32.50	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.74	0.71	-4.24	21	64	2009-01-15 18:05:59	2008-08-19 09:22:56	3	1	59	0	24	73	130	133.00	37	78.06	CHANGED	Atl+ppppsssphhhR.....ShpoLRDhctpoWQllha+cscs....tpslpLRlVGFPGphclsHPpsLhlpsuppphhhs....ssshh..tpssssssuEaDLsslLspLspspPL+LpLP...sshspLsVPPaVVpEWppL	.........A.l+ppp-tsGphhh+.....ShpoLRD.chpoWQlVhaKcsps....spslsLRlVGaPGphclsHPpsLplpsuptphlhs....ssshh....tpsstsssupasLsslLspLspspPLcLpLP...uh.splsVPsaVVpEW+sl........	0	3	16	22
+11153	PF11321	DUF3123		Protein of unknown function (DUF3123)	Pollington J, Finn RD	anon	Pfam-B_4246 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	44.10	44.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.45	0.71	-3.79	4	54	2009-01-15 18:05:59	2008-08-19 09:36:50	3	1	4	0	31	42	0	100.10	64	58.26	CHANGED	VSVRTRVGKLsss...pRpLVLWLuAVVVSsA-..E..GaLsVlYKGsFP.-DPF+sVRV.ARc-sKhhsssAAsssuss.s.................st.susAP.RPTTAGKSltlLKt.h.Et	..........................VRVRT.VG+LGTo...sh+LVMWLGAVVVSDAD..D....GHLEVIYNGNFPRDDPFRTVRV.AVKDVKL.uPRPAPTPA...........................NhAAP..RPTTAGKsLPRLKMhhLE.................	0	0	4	16
+11154	PF11322	DUF3124		Protein of unknown function (DUF3124)	Pollington J, Finn RD	anon	Pfam-B_4248 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.40	20.40	20.60	99.30	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.44	0.71	-4.21	30	107	2009-01-15 18:05:59	2008-08-19 09:39:30	3	1	102	0	63	113	21	125.30	39	72.35	CHANGED	LspGpTlYVPlYSplYoss.....cppshsLssTLSlRNTc.spslhlsplcYaDTsG+Ll+pYlspPltLsPLuosclll-EcDssGGoGANFIVcWpuspslstPllEuVMIGstusQGlSFsopGpsI	.....h..GpolYVPlYSpIYpts......cppshsLosTLSlRNTs.spslhlsplcYYDosGchl+sYlcpPltLtPluohchhlscpDspGGoGANFlVcWpusptlspPllEuVMIus.tu.sQGlSFsopG+sI............	1	20	45	60
+11155	PF11323	DUF3125		Protein of unknown function (DUF3125)	Pollington J, Finn RD	anon	Pfam-B_4250 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Staphylococcus.	19.20	19.20	19.20	19.40	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.75	0.72	-4.18	5	369	2009-01-15 18:05:59	2008-08-19 09:44:08	3	3	69	0	3	125	0	40.30	58	77.09	CHANGED	MIFSQNLFRRPTPThIVCRNWESNFSLLGP+.QLAp.scasF..chhLlauP	...........MIFSQNLFRpPTPs..hhTRIEK..SLLQAHF+SVNYCQYNFlccpTLIasP........	0	2	2	3
+11156	PF11324	DUF3126		Protein of unknown function (DUF3126)	Pollington J, Finn RD	anon	Pfam-B_4268 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Alphaproteobacteria.	25.00	25.00	29.60	48.30	24.40	19.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.71	0.72	-4.30	18	204	2009-01-15 18:05:59	2008-08-19 10:47:42	3	2	195	0	74	130	111	62.70	53	85.20	CHANGED	ElcKL-sYL+cpFtssplpVpsRP+psDSAEVYlG-EFIGVla+D--EGEhSYsFpMsILDlD	.....El+KL-AYhKRsFsNsclpVcARP+K.sDSAElYlu-....EFlGlla+D---G-lSYsFsMAILDhD...	0	22	45	55
+11157	PF11325	DUF3127		Domain of unknown function (DUF3127)	Pollington J, Finn RD	anon	Pfam-B_4273 (release 23.0)	Domain	This bacterial family of proteins has no known function. However, it does show distant similarity to Pfam:PF00436, with proteins such as Swiss:D1W984 being similar to both families. This suggests that this family may have a DNA-binding function.	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.80	0.72	-3.97	29	271	2012-10-03 20:18:03	2008-08-19 10:48:04	3	1	225	0	71	260	272	86.50	36	67.45	CHANGED	ElpGK.Iplls-ppshGp.sG..a+KpEhVlc.....TcsQYPpclplphhp.DKssh.sshp.sGpclcVuhslcuREas........s+aFsslpu..W+l-	............ElpGKlItllssppus.op.sG...a+ppEaVlE.........Tc-QYPp+lsh.....-hhs.DKlsp...slp.hG-clpVSFslcuREWs........s+aFNolpA..W+l-....................	0	28	57	70
+11158	PF11326	DUF3128		Protein of unknown function (DUF3128)	Pollington J, Finn RD	anon	Pfam-B_4309 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.20	21.20	21.20	21.20	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.12	0.72	-3.86	24	194	2009-01-15 18:05:59	2008-08-19 11:52:37	3	1	184	0	150	191	0	86.90	29	48.69	CHANGED	hPs.....shSChpAFDphhhCa...................olGGQh+shYRYGphssCscphccFhaClpppo.....................cspclpEha+cchhpp.........ptpsSSEDlWchR	........................p.phSCtpsFDthhhCh...................ShsuQhpshYRYGchc..sCspphsDahhChch+s..h.........................................+tptlp-ha+c.+thpt.........pttssS-DlWchR........................................................	0	41	82	124
+11159	PF11327	DUF3129		Protein of unknown function (DUF3129)	Pollington J, Finn RD	anon	Pfam-B_4316 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	25.00	28.20	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.35	0.71	-4.46	23	214	2009-01-15 18:05:59	2008-08-19 11:59:31	3	3	57	0	193	217	0	197.00	32	62.76	CHANGED	VsAHGslhsspGssGusss.uLulssuo...............................PRDssst.sssQtDToIhRstch.sstusshGRT.uuGsscsupsspthM...........................................................................................................uussLPpl.osGGslphThHQVNsDGAGPaos.lDsTusGs..tsapphpVTpslPGhs.t.....................................................................uhopupspDFPlsVphPushoCTGTVuGtpNVClVRspNsAtAGPFG	....................................................................................................................................tuHuslhss..pG.....s...sG..s..s.hs..ululs..ss..s...............................sRss.sp.....sshQtDoslh+ptph............s.sts......s.....s.hG+T..t.s...G..sh...s..h..sphspshh..........................................................................................................................sssslPpl.ss..sGp..lshT.hH..........QVN..t...DGA.GP..asCtlDsousGs....sap..shp..Vs.p.sl..PGts......................................................................shs.....t...u...p.sp-a.slplphPsshsCsGs.su...G....p......N....VClVRspN........sAhu.GPFG...................................................	0	84	133	176
+11160	PF11328	DUF3130		Protein of unknown function (DUF3130	Pollington J, Finn RD	anon	Pfam-B_4322 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.60	20.60	20.60	21.80	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.96	0.72	-3.94	2	128	2009-01-15 18:05:59	2008-08-19 13:10:10	3	1	49	0	2	91	1	82.80	54	94.66	CHANGED	MpEIKVcEcThppauochtppupu.sYLPhKsGNMAaSRANSIsQLRoALh-LV-sVEsFQhVscpDAoRLKphG.uaAhpDphhtphhs	.MpEIKVpEsThppHATKLtScusu.pYLPhKsGNMAYSpAN..SIsphRoALh-LVDsV-sFQsVsppDAsRLKchGhuas+pDQthupchs............	0	2	2	2
+11161	PF11329	DUF3131		Protein of unknown function (DUF3131)	Pollington J, Finn RD	anon	Pfam-B_4335 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.30	20.30	20.30	20.60	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.14	0.70	-5.78	24	249	2009-01-15 18:05:59	2008-08-19 13:20:03	3	11	171	0	76	236	7	243.20	30	16.30	CHANGED	hphApsAWpYFcpNhp.spTGL....VNolss...asosTMWDhuSalhALlAAccLslIsppEF-pRlp+hLssLuplPLhpspLPN+sYsTpTtphssYtspPst..lGWSAlDlGRLLlsLpllpppaPpasstlspllt+Wphsphlp.cGpLaGuphtps..thphhQ...EGR..lGY....EpYAApuapLaGhsshpAhph......tsa.p.hspl.GlslPhDsRcstph.ts.s.lso-PYlLpulEhGhD.st.............htthAcplapsQcpRacpTGhlTAhoEcslspuPYFlYssl..aupGpsWsoloc...sGpphsphp....slSoKuAFuhasLa.cssYocpLhptl.ppLhs..pcGaYpGhYEssutsscuhT.hNTNullLEuLhYptpGp	...................................h.phA+psW+YFtp.sp.tp.s.sL.........s.N...p.......ttpTo.hslGsYLhullAAR-hGhIshcEh.cRlptsLsoLs+hpha.pG.cL..phYpTpThp.......h.p....Ph.................h.SAlD.GpLhshL....hhlppt...............................................................................................................................................................................................................................................................................................................................................................................	0	16	35	58
+11162	PF11330	DUF3132		Protein of unknown function (DUF3132)	Pollington J, Finn RD	anon	Pfam-B_4348 (release 23.0)	Family	This viral family of proteins are 55kDa. No function is currently known.	19.70	19.70	20.50	268.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.63	0.71	-4.29	3	62	2009-01-15 18:05:59	2008-08-19 13:35:40	3	1	2	0	0	38	0	124.00	96	74.21	CHANGED	SSSHYFFSKNITPTSVERNFGGVAQLEVERAKLSFETFGNKFLLKDVFMFSDQSLGDNILSYTLLKEEGHIDGMRTAGDDVLLEKDGEVVMILDSRDEGRMWIKDDVWAEVTEHGSKSAREYCM	SSSHYFFSKNITPTSlERNFGGVAQLEVERAKLSFETFGNKFLLKDVFMFSDQSLGDNILSYTLLKEEGHIDGMRTAGDDVLLEKDGEVVMILDSRDEGRMWIKDDVWAEVTEHGSKSAREYCM	0	0	0	0
+11163	PF11331	DUF3133		Protein of unknown function (DUF3133)	Pollington J, Finn RD	anon	Pfam-B_4400 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.46	0.72	-4.39	13	112	2009-01-15 18:05:59	2008-08-19 13:43:25	3	2	20	0	70	97	2	45.10	40	5.96	CHANGED	uGGAPFlsCssChELLQlPpchhlsp+p.pp+lcCGuCSplLphSls	.......hGGAPFllCpsChcLLQl.Ptchhls.p+t.tp+lp...CGuCScllphsh.......	0	10	32	55
+11164	PF11332	DUF3134		Protein of unknown function (DUF3134)	Pollington J, Finn RD	anon	Pfam-B_4408 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	25.80	25.40	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.53	0.72	-3.84	16	82	2009-01-15 18:05:59	2008-08-19 13:50:37	3	1	74	0	34	81	101	72.70	40	82.45	CHANGED	NPuLpc.sRppPAsVlPl+pEssLLsWLcsoGRLlsc-.p-...c..osEEEElS-Lhus--sh.c..--ss--h	...NPuLpc.sRp-PAsVlPl+cEssLLsWLEsoGRLlsc..-pp-t....chsssEE..EElStLMut--sapsc.--ps-..........	0	5	23	32
+11165	PF11333	DUF3135		Protein of unknown function (DUF3135)	Pollington J, Finn RD	anon	Pfam-B_4409 (release 23.0)	Family	This family of proteins with unkown function appears to be restricted to Proteobacteria.	20.70	20.70	20.70	23.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.44	0.72	-3.82	23	146	2009-01-15 18:05:59	2008-08-19 13:53:26	3	1	145	0	36	92	4	80.70	49	70.31	CHANGED	ppLPsFD-LhtLAcssP-th-pl+cchscphIsssscphptRLcuhQh+IDthhp+sKNPhpsslhltphhpcphhchpp...sLs	........sLPsFDELstLAcccP-AF-Qh++-Ms-EMI.SAScsM.QpRLaAQQSHIDRVlup.CKNPsHsNVsLMpELppQhl+F+sAL.p..........	0	6	16	30
+11166	PF11334	DUF3136		Protein of unknown function (DUF3136)	Pollington J, Finn RD	anon	Pfam-B_4419 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	20.90	20.90	21.90	29.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.10	0.72	-4.55	15	46	2009-01-15 18:05:59	2008-08-19 14:02:40	3	1	27	0	17	48	116	63.50	56	84.37	CHANGED	LoIGELEAsYslYCKALRhLlt-G+s.pcIcRTlCWc+LppLHpSLPppY+SP-cLhthhQ+chp	.LTIGELEAGYPlYCKALRhLltcG+ohp-IcRTVCWs+LEoLpRsLPsRYKuPshLhsllpR-lp.........	0	1	6	12
+11167	PF11335	DUF3137		Protein of unknown function (DUF3137) 	Pollington J, Finn RD	anon	Pfam-B_4422 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.00	25.40	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.79	0.71	-4.51	34	227	2009-01-15 18:05:59	2008-08-19 14:23:45	3	1	152	0	68	230	31	142.20	21	43.07	CHANGED	hhTlFcGllhthshsKpFpupTllhpc.........sthhspltt.ttt.......p+lcL-sPpFEctF-VYosDQlpARYlLoPshME+lltLppph.....ssslphuFhs........sclhIslsspp......shFE..sslhpslsptpplpp.hhp-lpthhsIlcpLpLs	.............................................p..s.FpG.hhhhph....+p...hp...upshlhss...........tthhst.htshttth..........p+lchEs.s....pFpcpFpVausDplpARhlLoPshME.pLhplppph.....tsslphsFh.s........sclhlslsstp......shFp.......sslh...p....sl......s...p......p....tlpp......hhpclt.hhsllctLp..........................................	0	22	42	60
+11168	PF11336	DUF3138		Protein of unknown function (DUF3138)	Pollington J, Finn RD	anon	Pfam-B_4423 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	21.90	21.90	22.10	28.50	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.70	0.70	-6.32	4	54	2012-10-03 17:14:37	2008-08-19 14:28:28	3	2	46	0	17	61	7	491.40	62	97.68	CHANGED	MK+KhlsALlAhALPGhAs.....AuosAspI+ALQAQlssLQpQhsELpsu.LAApsu.......AAuG....QuuuAAAuusP.sD........ussshTpDDlsph+pQlANtpLKVDuLs-AAsTGPIAGLSVTGYlDPTYlaNRussTSuFQFhNH-.usYsYaNSTFGDVYLDIKKTFGVGPhAPSAEITlMPNRGsG.olhssu.GusGNNIlNTAVVsVPLSsTpTF.uGLhsSFGGYEVQQSNQMLTLTHsLLYDFSDPGShIGs.GhNa..spssWAWKFllGNEQaRTtGulspTGsNA.hGpP.TpSNpsPTFTARVDYshSSALDlGGShNlGRQTLhSusspAGG...YGhtssuuuPYGsaFFsEADATYTLuDhQYNAElDYGQQQ+uAaNGGpAQWYGlSLLuHRKasssslGRMGATLRYDaLsNsKNGGGGuuIuLsusG....hDsssGFGIDssCLAsSpANGs...ECKGAsR.AlshDLLFYPTQQlTVKlEYRHDWAsptVFLRsDGSYuKSNDLLusQhIYoF	.........................MKKKLICLLVAGALPGhAh......AuSTSApIKALQAQlsALQtQhKthpst.LAup.u..............uA...suGAtutss..u..sAsuAsP.ss.............G+ApAsLTsD-VopMKQQIAN.QQLKVDuLTDAAsTGPlA.GLSVTGYIDPTYlYNRAAGTSSFLFANH..E.......s.......s.....YNYFNS...TFGDLYLDIKKTFGVGPMAPSAEITLMPNRGNGITLLQNSRGsIGsNlLNTAVVNVPloA..oT.T.LVAGLlPSFGGYEVQQSNQMLTLTHNLLYDFSDPGSYlGh.GsNY..TKGsWAWKFhLGNEQYRTYGSVTQTGTNA.LGDPITTSNKVPTFTARsDYTWS..SALDlGGShNIGRQTLs.SAh..stssus.....YGsGGtAsSsYGsFFFuEADATYTLADlQYNAElDYGQQQHAAa....N...GG.h...AQWYGLSLLAHRKFNsPVlGRMGsTLRYDhLsNsKNGGG..GGGI.AL.NGNG....MD.s.usG...FGlDADCLAsSKANGGLGFEC.KGAsRQDVALDLLFYPTQQITVKVEYRHDWANNKVF.LR.NDG.S.......YuKSND..LLATQFIYSF........................	1	2	6	10
+11169	PF11337	DUF3139		Protein of unknown function (DUF3139)	Pollington J, Finn RD	anon	Pfam-B_4425 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.79	0.72	-3.70	12	437	2009-09-11 16:35:17	2008-08-19 14:32:33	3	3	346	0	28	180	0	81.70	40	65.70	CHANGED	MKKh.hhhhllhllllo....llluhhhaFsh...ptcpshchlssYlscptlppspl...Kphc.hphshKpG..haYttV.sFKD-PshpY.Yp	...............MKKhK.h.hhlIlllhIu........lllu.....h..saaF....uhcshpt+cs..lph..lDs.....YL.p.-.Ks.lK.ccI...Ko..cK....spYSsKcG.....ha..YpcV.sFKDEPs.lTYshp............................................	0	12	19	25
+11170	PF11338	DUF3140		Protein of unknown function (DUF3140)	Pollington J, Finn RD	anon	Pfam-B_4435 (release 23.0)	Family	Some members in this family of proteins are annotated as DNA binding proteins. No function is currently known.	25.00	25.00	27.50	27.10	21.70	20.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.09	0.72	-3.87	24	152	2009-01-15 18:05:59	2008-08-19 15:01:41	3	3	123	0	77	151	3	90.50	41	67.61	CHANGED	-Fp-lVNMospELccWLcT-cSpSsGpspc....GEosGHpSGRRIV-ILc....Kc+sDLoD-Dh-HM++VVuYl+RHLuQ.....pPcuc..hpcocWRaSLM	......-FpchVNMTssELccWLcoccSpssGppptt.........uEosGHcSGR+IlcILc....K++sDLo--DhcHMRKVVuYl+RHlAQ........cPsss....sp..cocWRaSLM..............	0	26	49	63
+11171	PF11339	DUF3141		Protein of unknown function (DUF3141)	Pollington J, Finn RD	anon	Pfam-B_4443 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	29.70	29.70	29.70	29.70	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	581	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.94	0.70	-6.18	28	171	2012-10-03 11:45:05	2008-08-19 15:06:39	3	4	134	0	86	231	61	521.50	42	76.93	CHANGED	DAhQRolLahDlhRpRGspah-HptpshPsVLtFcaEllhDGRcLP+PVNYuLlRIlPPss........hssDs...sK.RPFVVlDPRAGHGPGIGGFKsDSEIGlAL+AGHPCYFluFhPcP.PGQTlEDVs+AEutFlccVtchHPcus.KPsVIGNCQAGWAlhhlAAhpP-LhGPIllAGAPLSYWAGh....pGcNPMRYuGGLLGGoWlouLsSDLGsG+FDGAWLVQNFEsLNPANTLWsK.YsLYuclDTEusRaL-FERWWGGahhLNstEhpaIVDNLFlGN+LusGclhsuDG.pplDLRNIRSPIlVFsSaGDNITPPQQALsWIsDLYsss--I+upsQTIVYslH-slGHLGIFVSuuVA+KEHsEhsuslDhIDlLPPGLYEhsIs-ttssssssphh.spYhlchctRpl-DItu.hscssc-DERtFssVARlSElNhslYcpFlpPaV+AhsTs.sAchhRphHPhRlphphaSDpNPhhshlsshApplRpsRpPVusDNPFlphQpthSctl.puLDtaRDhRDshtEphFhslYuuPhlpALsGhpttpcs.t+......s.ss-cRphhphchtplpssl	..................................................................................................................DshQRulLahDshRpRGsphhpH.ttshPslLpFphEhlhDGRph.+PsNYuLlRIh...ssts.....................h.h.Ds.........tK.RPalllDPRAGHGPGIGGFKt.DSElGhAL+.s.G..H.PsYFl..sFhPpP.PGQ..Tlt..DVhpActtFlccVtt...hH..P..ps...+Ps.l..lGNCQuGWtlhhlAAhpP-.lsGPlllsGuPlSYWAG.....pGpN.PMRYsGGLhGGo..W.h...s...t...Ls.uD....L.....Gs.....G+FDGAaLVpNFEsLNPusshWsKhYsLYupl....Do..E..s..t..RaLc....FERWWGGahhLstp.EhphIV-NLFlGN+LspGplhh.......ssG.pplDLRsI+uPIllFsShGDNITPPp..QAL...sWIsDlYtssp-ltstsQ.pIVYhhHpplGHLGIFVSupVA++EHpphhsslchI-hLsPGLYEhplsp.ss........ssspt.p..........pahlphctRpl-Dlpt.....t.ps-phFtsVtplS-hN.thYctahpPhlpuhsss.sAchhcthHPhRhph.hhS.c.t.NPhht.lt.hAp.lRt..pRp.sss....tcNPa.hthpphhup.lttuL-haRchRDshhEthFhslYus.shht.hh.........................................h...........................................................................................	0	21	45	70
+11172	PF11340	DUF3142		Protein of unknown function (DUF3142)	Pollington J, Finn RD	anon	Pfam-B_4454 (release 23.0)	Family	This bacterial family of proteins has no known function.	30.00	30.00	30.50	30.00	28.80	28.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.33	0.71	-4.62	16	151	2009-01-15 18:05:59	2008-08-19 15:13:56	3	1	145	0	46	134	20	188.10	38	62.79	CHANGED	ssuR.hhu.sVhLssphps..Lchs-plhppllp.ltcWQupGsplsGlQIDFDAsot+LssYstFLccLRppLPtphtLSITuLhsWssou-...LssLhs.VDElVlQsa......pGhashsthtpal.pls+ls.lPF+lGLsphG.............Eh-sshp..............ppLhssP......................WFR..............................................................shslaLhNs	.............................s.ssR.shs.slhlssRhsp..Lchssplhttllph.hpcWpsuGsplsGlQIDFDAsTt+LscYssFLcpLRppLP..............s.shtLSITGLhDWspous...LssLht.lDElVlQsa...............QG.htsssphtpYLstlspLp....lPF+luLsphG.....................Eh-s.h...............p.LtssP..htthh..l........................................................................................t.......................................................................	0	4	16	28
+11173	PF11341	DUF3143		Protein of unknown function (DUF3143)	Pollington J, Finn RD	anon	Pfam-B_4460 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	28.70	69.00	22.20	16.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.08	0.72	-4.09	23	90	2009-01-15 18:05:59	2008-08-19 15:17:38	3	1	85	0	41	88	79	64.50	43	57.69	CHANGED	lGsp+ssp-.ssWtlppPsWsAplhL-pE-LtVpatpsG.....pcppRuFsYuLSRpDVEsAlhuG	.LGspQspp-hssWhlc+PsWpApL.LDh--LtVpYhpuG.t..tp-hpRsFpYuLSRpDlEsAlhuG.	0	6	26	37
+11174	PF11342	DUF3144		Protein of unknown function (DUF3144)	Pollington J, Finn RD	anon	Pfam-B_4465 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	25.40	25.10	21.60	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.52	0.72	-3.91	20	130	2009-01-15 18:05:59	2008-08-19 15:19:34	3	1	113	0	41	104	45	79.40	41	72.66	CHANGED	sFachADpFIpLANcpsppp..c.......sGcVuuuhhaAAARFNAahuussststsphts-K-pAlcaFsspY+cMLc-NL-Dal	.....Fa-RADpFIpLANphspst..c.........hGpVuA.AhhaAuARFNuahAAtshtpts-htscK-pslcaasppappMLp-NlD-Yh............	0	5	20	31
+11175	PF11343	DUF3145		Protein of unknown function (DUF3145)	Pollington J, Finn RD	anon	Pfam-B_4467 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Actinobacteria.	25.00	25.00	27.00	26.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.94	0.71	-4.83	17	330	2009-09-10 15:28:37	2008-08-19 15:23:36	3	1	327	0	91	220	102	153.90	50	92.65	CHANGED	VLaVHSAPsALCPHlEWAluusLuttVsLcWosQPstsGshRAEhsWpGs.sGouApLASuLRGWptLRaEVTE-sosGsDGtRasaTPsLGlFaAsTsssGslllsEsRLRshhp.utt....ssh-lt.cElchsLGpAWD-ELEsFRaAG-..GAsVpWL.+pV	.............VlalHSuPsALCPHlEWAluusL....sst........s....sLcWTsQPAtP.GphRAEssWsGs.VGTuupLAoALRuWphLRFEVTE-sosG.....s-GpRaSaTPsLGlapAshsssGsllVsEhRLRuhlstut.....sutpLssElsplLGpsWDsELEPYRtuGs..uu.VsWLpp.h......	0	33	74	87
+11176	PF11344	DUF3146		Protein of unknown function (DUF3146)	Pollington J, Finn RD	anon	Pfam-B_4468 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	22.00	22.00	22.00	71.70	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.61	0.72	-4.55	18	70	2009-01-15 18:05:59	2008-08-19 15:27:15	3	1	70	0	28	68	130	79.20	60	91.76	CHANGED	PpTTAalRVppQSasptpl-GEVpAGsFcWpFpWpFcpGc.LhVcPSLGRALIpDuLhRFLh+sDYpLEPGGDYsFTlRA+	.PpTTAalRlpcQSWppGplEGEVpAGsapWpFpWpFcpGc.LpVcPSLGRALIp-PLtRFLE+pDYpLEPGGDYpFTlRA+.	0	4	18	26
+11177	PF11345	DUF3147		Protein of unknown function (DUF3147)	Pollington J, Finn RD	anon	Pfam-B_4475 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	21.80	21.80	21.90	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.50	0.72	-4.04	11	537	2012-10-01 21:19:26	2008-08-19 15:39:40	3	2	300	0	60	163	5	109.80	44	87.60	CHANGED	hlL+FllGGhAVsluhIluphlsuK.hGGIFAsFPAVaLAAllhsGhpasupp....upplSpGAlsGMlusllClLsshhhltt.ptWthullhullsWFVuussIaplhph	.........................lh+FhlGGhAVhLu.IlusplshK....hGGIhAThPAVFLs.u.l.hhh.u.hpatsp..............uhpl.SpG..Alh.Ghhu.s.l..l.slhl.T.hhl+..t.+.ta..hhuh......Ihuhl.....sWFl.ulsIFphhch............	0	24	34	51
+11178	PF11346	DUF3149		Protein of unknown function (DUF3149)	Pollington J, Finn RD	anon	Pfam-B_4495 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.60	20.60	22.10	21.10	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.89	0.72	-4.40	14	230	2009-01-15 18:05:59	2008-08-19 16:01:56	3	2	230	0	48	142	6	38.60	43	21.33	CHANGED	chWhpL.FusslGLhShhVIhhslGlhuahsthFlhKhhpssp	.....hhhpL.FusslGL.SMlVIlsslGlhhaahuaFhYKhhp-pp..........	0	5	22	35
+11179	PF11347	DUF3148		Protein of unknown function (DUF3148)	Pollington J, Finn RD	anon	Pfam-B_4488 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	34.60	33.40	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.98	0.72	-4.36	23	92	2009-01-15 18:05:59	2008-08-19 16:04:34	3	2	88	0	41	92	86	62.20	48	59.37	CHANGED	slGspV+Lhst.PYLKTADPMPMLRP.PDLVslsE.GpVluh+PtshhuVRFcRGoFLlssphL	...lGspVpllthPPYLKTA-PMPMLRP.sDllplu-.GtllsR+PtshWuVRFs+GoFLl-upYl..	0	7	26	37
+11180	PF11348	DUF3150		Protein of unknown function (DUF3150)	Pollington J, Finn RD	anon	Pfam-B_4471 (release 23.0)	Family	This bacterial family of proteins with unknown function appears to be restricted to Proteobacteria.	23.50	23.50	23.70	25.50	23.30	23.40	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.42	0.70	-5.29	25	147	2009-01-15 18:05:59	2008-08-19 16:09:22	3	1	122	0	27	96	19	250.10	31	72.16	CHANGED	lLcsllllsLs.lslWoG+K+Lps.cDlth......splPPpplAoLGoK+lhDPcsLpsFsplKpcAp+hhpchGl+F..LG....GaAlPpccssplspcLcsIcscFtpt............KpsFLssY-ptlc-Whsp.s.sc.......auslI+ssss.stcplcpplsFsap..hhclpsss.......thscuLsppVsuLsspLhpElAppAcc...haccsht.........G+..pplop+sLss.L+slpsKlsuLuFlcP.plsslsphlcplLsslPc..sG.slcGsphhplhulls.hLscs	..............L-plllhcl-.hslWSGc++Lps.pDhphs....suplPPcclASLGSK+IsDPcsLpsFppLKpcApRLh.pphGlRF..hu....GaAVPps+h-plsscLscIpp-Ftpt............Kpp.FlssY-pslp-Whsc.p..Pc........auc.hIRpuh..sh-sVcpRlpFsat..hhphpPs............ttstsLsccVss..hucsLhpElAp-Apc...haccshs.............G+..splspps.lss.L+pl+-KlsuLoFlcp.chpPll-hlcphhsplPc....sG.slsss.htplhuhlhhhSD...................................................................................................................	0	10	19	22
+11181	PF11349	DUF3151		Protein of unknown function (DUF3151)	Pollington J, Finn RD	anon	Pfam-B_4506 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	37.00	36.80	23.80	18.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.63	0.71	-4.13	18	342	2009-01-15 18:05:59	2008-08-19 16:16:08	3	1	337	0	92	227	37	130.20	54	86.91	CHANGED	LhGPPPohLPs-ssApttLssGsss......ssVAAcHPsuSluWAt....LAEpALssG.............csVpAYAYARTGYHRGLDpLRRsGWKGaGPVPWuHEPNRGFLRuLuALu+AApsIGEs-EhsRCtphLcDuDPsAsspL	............................huPpPlhLPs...D...s...ssc.thhttupss......ssVAspHPouSluWAh....LAEsALts.s.................psVsAYAYARTGYHRGLDQLRcsGWKGaGPVPauHpPNpGhLRsltALA+AAptIGEsDEhsRCpshLcDs..sPpAhtsL......	0	29	70	88
+11182	PF11350	DUF3152		Protein of unknown function (DUF3152)	Pollington J, Finn RD	anon	Pfam-B_4512 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.10	25.10	25.30	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.34	0.71	-4.80	17	313	2012-10-03 04:41:15	2008-08-19 16:23:17	3	2	261	0	93	280	119	198.50	43	61.58	CHANGED	LssG.ushspsGsGTacsVsususplGpGt.+hapYhVEVEsGlsssu..sssuFAthV-tTLusP+uWo..pssphuFp+V-sus......PDFRlpLsSstTscphC...GhchthE.sSChs.......ssRVhlNpsRWlcGAhsFpGDluuYRQYlINHEVGHulGa.sHpsCstsGtLAPlMMQQThulss..................ss..CchNsWPaP	...........................................l..sssasptGssTacsV..s...u.s.s..sps..G....pGt..+lapYsVElEsGlssss...s.suFAphV-pTLss.P.+.uWs.........cssphuFpRlsuup......................PDFRIpLsSPs...Tsc..p..hC....GhchphE....sSChss.............ssRVhINtuRWl+GAss..F...p.G...D......luuYRQYl..INHEVGHul.G...a..sH-sCstsGtLAPVMMQQThulsst.....................c.....shhCp.NPWPYP.........................	0	28	67	89
+11183	PF11351	DUF3154		Protein of unknown function (DUF3154)	Pollington J, Finn RD	anon	Pfam-B_4516 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	24.80	24.80	25.40	24.80	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.63	0.71	-4.37	32	105	2009-01-15 18:05:59	2008-08-19 16:45:58	3	1	98	0	38	117	312	117.70	25	71.28	CHANGED	ssltcss-sFhsNsEptuttptphpptulpQhutEFts...tuhacphhsulNRlP...........RPshuhushuLhlhA.hhcPlhFustMtuhul.............VPEPLWWLhGslVuFYFGAR..p.sKspshp	...................................................sltphh-hhh..ss-.ttsttphphpt..tthppht.t...Ehth.....t.....sh.....hcphhstlNchs...............RPhluass.hul.......hlhu..hhsPlh.....hstthtuhsl......................lP.-.sL..ahLlu..ssl.hY.huu.R..p.tKtpt....................................................	0	13	27	33
+11184	PF11352	DUF3155		Protein of unknown function (DUF3155)	Pollington J, Finn RD	anon	Pfam-B_4534 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	21.00	21.00	24.00	109.80	19.40	18.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.75	0.72	-3.76	6	71	2009-01-15 18:05:59	2008-08-19 17:19:52	3	1	69	0	28	65	125	88.50	74	75.98	CHANGED	ARRRKRKSRRR.EGRRIL-hVPQYuIESGE-KPVTAAR+FIcupGItPPAlLlV+RNEHTTDRYFWAEKGLFGAQYVEENHFLFPSL+lL	............u+KRKRhSRRR.tGpRlLtpVPpasIEoGEcKPVTAAR+aItppGIhPPALLhV+RNEHTTDRaFWuEKGLFuAQYsEENHFLFPSLRh...	1	5	18	26
+11185	PF11353	DUF3153		Protein of unknown function (DUF3153)	Pollington J, Finn RD	anon	Pfam-B_4513 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria. Some members are annotated as membrane proteins however this cannot be confirmed.	20.80	20.80	21.10	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.28	0.70	-4.89	26	198	2009-01-15 18:05:59	2008-08-19 17:20:04	3	4	196	0	50	139	128	206.20	24	80.70	CHANGED	lh.lllhLolLLoGCVchcsslshsu.c......+lpLuhplsShosphh.PWppphcpph+phtsphp.....psspsch..plpssshsup-hpphhpphhsssup..........suuls.hsss................plplpcpNaLlulcppLplslDLcsLs.lss...........LsLplsLssshshpthptss.s.st.t.......pt.plsWpLpsGclNcL-hsh.........WhhS.LGlGullIllllhluhhLpth+hph	..................................................................................................................shlLhLl.LLoGCl+lcsolslsscc.................................tpIs...hs..h..........sh...s.S.....h..s..st.s..shtsshpp+.l..p..tts.hssc.......p.s.h...thp..hsh.....s..ht-.l.phh...hs.ssp..............sssls......................lslcpss.ll.h....LphchDL.pslss.ss......................-lphslshPht.spsh.....susp....t..................p...lpW....pLpPG.lsphpsp.........................................................s.................................................................................................................................	0	12	30	44
+11186	PF11354	DUF3156		Protein of unknown function (DUF3156)	Pollington J, Finn RD	anon	Pfam-B_4555 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	19.10	19.10	19.40	19.30	18.10	17.50	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.96	0.71	-4.86	12	216	2009-01-15 18:05:59	2008-08-19 17:21:06	3	1	212	0	21	130	0	157.70	53	85.54	CHANGED	psLuu..p-t.ut...puthhphssGlplclpERscppFLhHlVSscaplpsssshsspuph+l+psGWLRRpGlsstsppGss.t..tllstLp.s.PsLtpsLtsLDa+chslstc.....supWplslE.aGASEVVsRhPuaRRYlRLssEQRhhLhuuhhthpphLp	.....................RDLuGahCE+LoE...+SAlL+Lssh.spVhs+.ppKRLFMASIpSCEFcVcGsls..hPlpG+IRlHQsGWLKR.hPVlFsuuKuou....uLlsaLN.paPsLQQALSELDaRRFoLVlH.....c+cWhCSIEhaAASEVVC+MPPlRRYLRLEccQRlLLLSVlsMlsQAhs....	3	3	4	12
+11187	PF11355	DUF3157		Protein of unknown function (DUF3157)	Pollington J, Finn RD	anon	Pfam-B_4561 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	21.70	21.70	23.40	22.30	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.30	0.71	-5.02	15	126	2009-01-15 18:05:59	2008-08-20 09:00:52	3	2	125	0	23	84	4	187.60	46	94.64	CHANGED	h+shs..llALlLls.....soAhAA-......thlTLEsGtpVpL+DDFTWEYlhhcots.................p.ss.sstssssssusssssssPsss..........ssp..hTshslupsc.ltphuKuGlcVsLssupa-us.cLsLshslospSocsVlhVclclolas-sGplLcpcclplWpuIhRMP-TYLRttppccucslhl-ss-+spap...lslcIhElco	....................................................MKphlLlAsllsh......SsaAuE.......slpLcDGR.lpLNDDFTWpYV.pETps............................tpsophuPllhusPVls...........psT..GsolsVusc+PlhQLSDSGVDVlLuuspYEpG.pLtLoouITNQSSQSVItVcltlpV.DspGsh.ccpcVTlWQSIKRMAETYLRPppuhcGKslcLsls-puQYp...lpApIppI-T................................	1	2	4	14
+11188	PF11356	Pilus_PilP		Type IV pilus biogenesis	Pollington J, Finn RD	anon	Pfam-B_3750 (release 23.0)	Family	Type IV pili are required for auto-agglutination, twitching motility, biofilm formation, adherence and DNA uptake during transformation [1]. PilP is an inner membrane protein, required for pilus expression and transformation [1]. PilP interacts with PilQ which suggests that the two proteins may have coordinated activity in functions such as pilus extrusion/retraction [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.67	0.72	-3.75	91	1330	2009-01-15 18:05:59	2008-08-20 10:47:43	3	3	966	2	259	918	191	88.20	22	37.51	CHANGED	lauphssttt..ss..............sssuspopLsl...pLhGll..ssssppuhAlIt..ssupppsatlG-plsG..ssplppltsD..+Vll.ppsGchcsL	.....................................................................................................sssssp.sphs.l...sLtGll....st...sppuhAlIp...psspQp...shthG-p.lsu..ssplppIptD....pVll.pppG+hpp..............	0	73	139	197
+11189	PF11357	Spy1		Cell cycle regulatory protein	Pollington J, Finn RD	anon	Pfam-B_3875 (release 23.0)	Family	Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events [1]. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27 [1]. Spy1 is also known as Ringo protein A.	25.00	25.00	29.30	25.60	19.50	23.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.65	0.71	-4.07	6	228	2009-01-15 18:05:59	2008-08-20 11:48:45	3	6	51	0	119	278	0	110.50	46	48.09	CHANGED	p-hpAFh+LLEDslVQcFLuhDpsh+lSDKYLLAMVlsYFpRAGLhstpYs+IpFFLALYLANDMEEDppssKp-IFsahLGKs.WpphhPpFLKLRcphaspMsaRAhVSRcpCEEl.AhsPpHWlWsRDR	........................pchpAF.+Lh-.D.sllpcFLhh....Dhsh+lu...DKYLLAMVh..sYFp.RAt....h...p.Yp+lpFFlALYLANsM.E.EDpptsK.pIF.ahhG................+..........s...+sph.s.FhKhR.phappMsaRAhVSpcphEEl.Ahs...PpHalWtR-R..................	0	37	40	55
+11190	PF11358	DUF3158		Protein of unknown function (DUF3158)	Pollington J, Finn RD	anon	Pfam-B_3964 (release 23.0)	Family	Some members in this family of proteins are annotated as integrase regulator R however this cannot be confirmed. This family of proteins with unknown function appear to be restricted to Proteobacteria.	21.10	21.10	21.70	21.30	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.98	0.71	-4.74	14	141	2009-01-15 18:05:59	2008-08-20 11:49:37	3	1	114	0	44	138	10	148.80	45	91.21	CHANGED	FpsLpQssFppLp+uA....sLKGLLpPFKGKGsL-thApQCpsLRssLhsLAp.plLsQspphPFs.LLsVcLsp.QsTuAGTTFLRWR.....phDputMGVulWppllssstTPssLlcDLauhEhQRIsLNMQISLlHoluRQAt-CAsKhApAEssYhpRhtthsss	..........psLppssa.pLpHuu....sLKGLLKPF..KGKGphpthAppCtuhR-tLhsLAp..plLtQ.AptaPap..LLPlcLsp.QsTuAG...TsFLR........WR.....phspspMGVulWpplhsss......pTP.sLlp-LauhEhQRIsLNMQISLlHoluRQAtECApKhupA-ssahpRhtt...s...................................	0	5	21	34
+11191	PF11359	gpUL132		Glycoprotein UL132	Pollington J, Finn RD	anon	Pfam-B_4015 (release 23.0)	Family	Glycoprotein UL132 is a low-abundance structural component of Human cytomegalovirus (HCMV) [1]. The function of this protein is not fully understood.	24.40	24.40	24.90	33.70	22.80	24.30	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.57	0.70	-5.03	3	84	2009-01-15 18:05:59	2008-08-20 12:50:24	3	1	12	0	0	73	0	190.80	78	86.68	CHANGED	MTSSTssPooTsoosTVToATSsssosSTNlTTAa-uSTpsc.ss.lpclLuIllYCVoGoSILSFLlVLlAVLYSSCp++PGRha+FoD-EuApLLD.sDDsGupo.h...GuGSRRG.pIPAu.SSSShYQRL-stDaDE..-usSAAREoMc+DP-.NVIYF+KDGNLDTSFVNPNYG+GSPMTIESHuDDDEc..IRYYMSVYDELTASEMEEPScS.sWQIPKLlKVoTpPVTLKEPEY	......hTSSTsVPTSTSSRNoV-sATSSs.PTTuhNMTTsHESS..VH.ssRNDEIM...KVLAI...LFYIVTGTSIFSFIAVLIAVVYSSCCKHPGR.FRFA..DEEAVNLLDDTDDSGGSSPF...GtsSRRu.......ssSS.hpRLpspDapp..pptStscpp.ccDs-.N.VlYFcKcGNL.sSFVNPpYG+tSshhIESphsDsEp..I+YYhSlYDELsAptMt-PSpS..WpIPKlhKVuhp.VoL+-PEY.........................................................................................	0	0	0	0
+11192	PF11360	DUF3110		Protein of unknown function (DUF3110)	Pollington J, Finn RD	anon	Pfam-B_4086 (release 23.0)	Family	This family of proteins has no known function.	20.20	20.20	20.30	20.20	18.70	20.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.92	0.72	-4.17	25	139	2009-01-15 18:05:59	2008-08-20 13:01:11	3	4	125	0	55	137	647	85.00	34	47.06	CHANGED	VaVLLasAGo-sEGIHSLclsu.........cslVLMFEscDDApRYAsLLEAQDFPsP...oVEsl-c-EI-tFCpcAGY-sclVtuGFhPts..-RLLluPP-p	...............haVLlap.s.p.-sEGIa.olp.hss.........+stVLhFEscDDApRYssLL.EAp.Da..sss...sVptl-sc-ltphCppss.Yphplltts..........lhh.PPp........................	1	15	39	51
+11193	PF11361	DUF3159		Protein of unknown function (DUF3159)	Pollington J, Finn RD	anon	Pfam-B_4163 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.	25.20	25.20	25.20	25.70	24.30	25.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.03	0.71	-4.82	29	387	2009-01-15 18:05:59	2008-08-20 13:48:20	3	2	327	0	139	362	262	187.60	35	79.02	CHANGED	hGGhpGllcSslPsllFlss.s...........htsLhhulhuAlulAsllllhRLlpRcslpsAluGhhGVuluAhlAhhoGc........A+saFLhGIhhshsaullhhlSlllRhPllGhlhuh....lpucst........sWR.ccpthlRAashuThsWsslassRhlVQh.LYhu...spsu.........hLusARlsMGaPLhslulhVoahsl+putpt.	........hGGhpGllp.SsLPsllFVls..s...........s.tuLts..ulhsAluhAsll.hlhRLl++c.slp.s.A.luGhh..GVuls.Ahl..Aaho.G.p........A+saFLhGlhhshs...hullhhlSlllRhPllGllhuh.....lpup.st.................................sW.........R..ps......s...h...h...+A...ashAThsWshlFssRhlVQh.L.Y.u...spss.........hLGsAR...lsMGhPLhuLulhloahhl+ps...h.........................................................	0	44	101	127
+11194	PF11362	DUF3161		Protein of unknown function (DUF3161)	Pollington J, Finn RD	anon	Pfam-B_4173 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	25.40	26.20	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.01	0.72	-4.08	7	30	2009-01-15 18:05:59	2008-08-20 13:54:41	3	2	18	0	17	31	0	77.50	33	35.88	CHANGED	pchLpsslc.ssh.SssAhsctRuhlss.Nt.aKalt-+shp+GusVPVhIsEhhp-GLpspsQTt...s+KlsshhpYhppoaFc..llcVls	..........slp.stF.slssLh+tRu+lsslNhlaKhlh-.....+shp.K....Gu.......s.lPlhls-hhphGLpstuQTs....tKLssh......pahc..llpl.................	0	8	10	15
+11195	PF11363	DUF3164		Protein of unknown function (DUF3164)	Pollington J, Finn RD	anon	Pfam-B_4249 (release 23.0)	Family	This family of proteins has no known function.	23.70	23.70	23.80	25.60	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.01	0.71	-4.91	30	235	2009-01-15 18:05:59	2008-08-20 14:24:56	3	1	198	0	53	219	8	187.30	33	91.65	CHANGED	YhpDAcGpLlP.stlKslDph....RDchVpclVspActlppplscFKscsFsDluAFlsLSAccYus.+lGGpKGNlTLhSFDGpYKlphtls-plsFDEcLQAAKsLIDEClp-WopGucsEl+ullscAFpVDKpGplssu+lLuLRRlcIsDc..+WpcAMcAIuDSlpVsGSKsYlRhYER.ss..supapsIsLDlAs	..........................................ah.supGpLhP.t.l+shDth....cD-hVpclhspAttlpppltpFK.tpshs-lsuFlsL.A-cYus.ch..GGp..KGNlTLh..oaDGph+lphuht-plsFD-.c.l.ps.A.KsLI....D...-ClpcW.oc....G.u.c....s.c.l.psllppAFps...D.KpGplsssclLtLR+l..c..Ip...D...p...cWpcAMpAIs-ulpVssoKsYlRhacR.sp...sspap.IsLDlu............	0	16	37	45
+11196	PF11364	DUF3165		Protein of unknown function (DUF3165)	Pollington J, Finn RD	anon	Pfam-B_4331 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.00	25.00	27.50	27.00	23.50	22.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.88	0.72	-3.85	7	341	2009-09-10 15:00:51	2008-08-20 14:42:00	3	1	339	0	21	93	0	81.80	62	96.35	CHANGED	MhYLIluILllhaYlFhAPcSIKsThNhluhVhllshLllLhsLuhl+IhQhPsEhFlGluMllluYaAL+DIhphspcs+.	..MVYLllGILLLLLYlFATPcSIKGTVNIVuMVslLVALLILLVLSFLKIFQLPoEIFluIAMLlLAYFSlRDIoLMPlKKp+...	0	1	4	12
+11197	PF11365	DUF3166		Protein of unknown function (DUF3166)	Pollington J, Finn RD	anon	Pfam-B_4333 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.90	21.90	21.90	22.20	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.26	0.72	-3.53	4	340	2009-01-15 18:05:59	2008-08-20 14:45:14	3	3	45	0	193	276	0	94.50	47	14.45	CHANGED	EDsuDLRCQLQFs+EEuuLMRKKhAKlscEp-chcpELpKY+ShaGDlDS...huchsuGuPcosRpttLcLcLKhsc.puNhLutKlsEL-sENR..sh+	....Essu-L+ppLQFVcEEApLhR+phAcl-ccNcplpp...ELpK.Y+o..h...a.G.-lDu.....................sp....p.....t..u.u..ss..ss.......+p.s...t..L.p.cLKh...sc.phN.LStKlhcLphENR..hLp....................	0	20	34	85
+11199	PF11367	DUF3168		Protein of unknown function (DUF3168)	Pollington J, Finn RD	anon	Pfam-B_4337 (release 23.0)	Family	This family of proteins has no known function but is likely to be a component of bacteriophage.	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.80	0.71	-3.96	123	1027	2009-01-15 18:05:59	2008-08-20 15:06:50	3	4	854	1	179	692	99	112.10	16	88.23	CHANGED	slhttLtss.s...slssllss........la.....-tsP.......ts...s.....shPalslutspspst.ssh...ssts..t..phplplcl...a...u...pss.......tps.s..ppl....ssslpsAL................t.hthhthphttspsh..pcsssh.....hh+.....ss..lph	.........................................................ltthhss.........la........ch.hP........ps.......s....shPal.shs.h.p.s.hss..ssh...ssps..t..phtlplcVa.....u......pss....sps.h..ppl...tptltpsl..........................t.phh.tsh..p-.pt.......hh+h............................................	1	46	110	141
+11200	PF11368	DUF3169		Protein of unknown function (DUF3169)	Pollington J, Finn RD	anon	Pfam-B_4342 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.60	25.60	27.20	29.40	25.50	25.20	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.57	0.70	-5.17	11	562	2009-01-15 18:05:59	2008-08-20 15:09:01	3	1	550	0	31	240	2	235.20	36	99.32	CHANGED	MKpt+p......hhRhlhhlLluullGGllGhhsuth.......hpplshsshtslthlphlupllllllhshshhhhhpshKapphhppphD-Dtsc..ph.ppt.+phphuoIlhslshllshlsllls..hllshhsssss...Lhhslh.hlhhlhhlhhplhhhKhhphl+sh+hsthsshc.hcchhtuhDEuE+ptphcpuachhhslNthlL.slhllLhlluhhTs.splhulLllshIal.....Ylslthhhhs++aa	............................MK.............hLhalhhllLG.G....hlGhh..lGh.hhuph-.........cplhhs...sh.s..hsh..ISh......lshlI.hh.l...shh.l.shh.hh.+.+.uhKa+pLhp...c...Eh.D.-Dhs-..pY.lph.Rp......lth...GoIhhslps..lhh...hlslhI.....Vl.hh..tsssth...............hah....h....h...l...hhl...hhhhhphh..hhKh..t....h..p.c.hs.hhAs.c..scchlp.t.h.DEGERphpLptsF+hhht..s.hlL..hhhlhlh.lhSh.hT.G..Q.hhuh.L....Llh..AIal.....Y.shh.L.hs+Raa............................	0	4	12	24
+11201	PF11369	DUF3160		Protein of unknown function (DUF3160)	Pollington J, Finn RD	anon	Pfam-B_4384 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	38.00	34.70	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	631	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-12.86	0.70	-6.20	17	97	2009-01-15 18:05:59	2008-08-20 15:47:45	3	6	73	0	39	99	5	586.80	29	79.38	CHANGED	sLspsshshLp+NGFVVl.........ts..ssppcplsph........YcsLc.p.........slPlFIToDSlLHlYHIQFD-TL+plEcccFastLWclspsLLssSlcsYs.....suoGc...+EAARRNsAYFuVAhsLLp..Pc..pht........................tpaphElPuhV+p-VEAELsLI-AppGhshSPIF....p......YpE...DYSQYlPRGHYT+S-pLpsYF+AhMWaGRhShLLcss...........p....................stp.....-AplQTlp....AhLIosphc.pcpcLhccWcRlYslTAFYVGhSDDLGPYEYhcALcsVFGsp....tsshsspslpcL+scLtchcs...PcIYGGTGthh....hss-ttsppLcsTcGFRhMGQRahPDSYlhpsLl.........................s......RhaPpGLDlMulLGS-RAtphL.cphs..SsapsYstpappL-sEFsuhsst-WN+NLYWuhLYuL..pPLhpsassGYPTFMQTpAWpDKpLsTALASWTELRHDTILYAKQsYs....psushs.pE........psshGYVEPsP-FYsRhLALT+MTpsGLs-hclLDcpuc..........pchppLcshLp+LhpISpKELENKcLT-E-Y-aI+sFGpplpsh..............htsVDtcspposlVADVaTss.....tstVLEEGsGhlDhllVAYc.sDGRlhlusGPVhSYYEFhQPhu-RLTDEcWR-ML.pspsPE..+PEWs	.........................................stt.hthLtpNuFslh.........................s...p.pplhph........Yc.ptchp.....................phP.FlToD.hLchaHlhFDphL+plEcpphhstLhclsp...shhptp.hpphp.....p..pspp..hcpsAtpshs.aFulAhtLLp....................................p.plPtthppt...sptElph.Iput....ps...t.Sshh.s............hp-.....DYS.apPRGHYT+s-..pLppYF+uMMWhGphsFhhpsp......................................tphhp....Ahlls.phhp.....p.phhchWpplapshsFhhGpoDslshhchtphlppshstt.......h...hsppth.p......phh...tpl.tp..h.tt...spI.s................................p.ppstsaR....hMsQRah.Du.lhppLs...................................................ststt..RshP.pGLDl.hAshGocpAtplL.cph.t...ppap....pYptph.pplcpphtshstp.t.hppslYtsWlhsL....tsh.hpp......hs..pshPsFMpotsWppKpLsTuLuSWsEL+HDTILYuKQshs.......EhG.sss...t..............shGY..VEPssphap+hh.......sLsphstps.....Lp....p.....hsh......ls-ptp..........tphpplpphhphLhpIucKELp.sp..pLop--YchIp.h.Gs.pl-.h.................................hps.sts.spphslVADVhTss........ts..tlLc.GsGhstplhVsh..hsGpl..hlspGsVhSYYEFhpsh.s.c.RLTDEcWpchL....ptpsst.....hPtWh...............................	0	23	28	33
+11203	PF11371	DUF3172		Protein of unknown function (DUF3172)	Pollington J, Finn RD	anon	Pfam-B_4527 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	55.60	54.20	20.20	19.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.78	0.71	-4.68	10	83	2009-01-15 18:05:59	2008-08-21 09:45:08	3	2	78	0	41	83	146	136.60	53	66.78	CHANGED	FNhuTlA......lLGGVhVLGIGIGluhSSTsohsPpNVASpEhIDpuAPssElCVQaGASAhVhDhRlFlTLNPFsVaVoQPsMQPGCVLRRsNWslLEQcpLlou-QlR-CKsRMNTFGYsGsL-u.cPcIcClYQN-uApNLF	........hNhsTlAlLAGlhVLGIGlGhuhoSTsshsPpNlASp-hlDpusPsPElChQaGASAhVhDhRlFlTLNPFslaVoQPshQPGCVlRRsNW.ulLcp.ctlloscQlR-CKpRMNTFuasGsLcs.pPplcClYQs-supNhF..................	0	12	30	39
+11204	PF11372	DUF3173		Domain of unknown function (DUF3173)	Pollington J, Finn RD, Bateman A	anon	Pfam-B_4543 (release 23.0)	Domain	This family of proteins with unknown function appears to be restricted to Firmicutes. These proteins appear to be distantly related to HHH domains and are therefore likely to be DNA-binding.	25.00	25.00	25.20	29.10	21.60	24.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.66	0.72	-4.36	20	326	2012-10-03 02:11:09	2008-08-21 10:35:08	3	1	232	0	31	166	3	61.50	41	86.57	CHANGED	ptTlo+pDLIclGappppApsII+pAKplhVp.+..............GasaYsNKRLshVPsulVEE.lLGlpl	........tTlopcDLlpl.GaspppApcII+pAKplhVp.+..............GasaYss+RLshVPtplVEE.lLGlpl.................................	0	5	15	23
+11205	PF11373	DUF3175		Protein of unknown function (DUF3175)	Pollington J, Finn RD	anon	Pfam-B_4566 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	21.00	21.00	22.40	22.40	18.10	17.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.80	0.72	-3.96	14	130	2009-01-15 18:05:59	2008-08-21 10:43:47	3	2	128	0	55	117	6	83.60	60	71.96	CHANGED	+WSpcVTE+SsALDLEtsVFp.cDPccIAtSLKRSA-pScRRKuoPFpSAMSMLsFYINRAG+sLscspRpsLEcAK-ELRctFGR	...............+WSpcVTcpSD.ALDLEtslFcpcsPccIAtSLK+SA-cScRRKusPFQSAMSMLsFYINRAG+sLscsRRpsLEcAKccLRcsFGR.........	0	12	29	40
+11206	PF11374	DUF3176		Protein of unknown function (DUF3176)	Pollington J, Finn RD	anon	Pfam-B_4567 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.40	21.40	21.50	23.40	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.31	0.72	-4.19	34	177	2009-01-15 18:05:59	2008-08-21 10:46:33	3	4	49	0	146	180	1	104.10	27	17.65	CHANGED	llulLhhhcs+shss.Wsh...hloLNsllSlLoTlspushhhslupuluQLKWhaFp.ppp...p.......LsDhphhDsASRG.saGulh.lL.....hphps+.pluslGul....lhllu.luhsPFsQQllp	.........................lslLhhhcspslsp.Wsh.........hlohsslluhlsslspuslhhslupuluQhKWhhap...pt......p.......LtDhphhDpASRG..shGuhh.lL..........hphps....t...t........lusluul....l.hl....hs.hhhsPhhQphl.s...................	0	21	72	113
+11207	PF11375	DUF3177		Protein of unknown function (DUF3177)	Pollington J, Finn RD	anon	Pfam-B_4580 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.00	25.00	74.10	74.00	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.43	0.71	-4.85	22	74	2009-01-15 18:05:59	2008-08-21 10:54:46	3	1	72	0	29	77	136	186.90	44	95.59	CHANGED	hcsLVWLsYRLAshFslulPLlLLIWAhh++tsAl.RLLsIYW+VuSLLsIolhLhhsph............PlualouhlA.lLhslSl....WFWVDLNEELtDhPs.pPLsLsh+hWRWulTsaulluhhhshssLsCshshs....tss.CpsWLEsP.........lFchlFtushotuhhuFlGhluLlhYllsLlpalllRLP+QGRsAst	......psLlWhDYRLAllFslhlPLlLLIWuhhc+.culsRLLhIYW+VASLLhITlhLhlsth............slualouhhAplLIslSl....WFWVDLN-ElcDhss.psLtLshpsWRWAlThausluhlhplshLsCuhshs....sss.CplWL-sPh........hac.hFtushssuhhuFlGhluLllYllhLh.alllRLs+QGRsAh.t......	0	5	19	27
+11208	PF11376	DUF3179		Protein of unknown function (DUF3179)	Pollington J, Finn RD	anon	Pfam-B_4591 (release 23.0)	Family	This family of proteins has no known function.	19.30	19.30	23.00	22.10	18.70	17.50	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.62	0.70	-5.22	35	131	2009-01-15 18:05:59	2008-08-21 11:11:21	3	4	102	0	49	143	88	243.70	28	77.52	CHANGED	P+DGIPAls.....sPpFhssspssh..lcss-sVlslplsGp..sRAYPh+ILsWHEIVN.Dpl.uGtPluVTYCPLCsouhs.F-cplss..tslsFGVSGpLhNSshlMYDR....pT-ShWpQhhGpAlsGsh....sGppLcplPshhpoWspa+pcaP-u.hVLupssuapRsYup........sPYss.........YDsssp..h......lassthsscc..lssppcVlGl.shtst.thAashspltpts.....t.plsspslslsacsstsS.....................thhsups....................................pclsphssF..WFAWt.....A..FaP-osl	.....................ssIPuls.............pPpahs.stpsp...ltsp-.Vhsl.thsGp..s+AYPhphlhaHElVN..Dpl.ushslslTaCPLssouhs.a.cpph.ss.............t.hpFusoGhLhpushlhaDR....pTpShWpQhhGp..AlsGsh...........tGppLp.lP.shhpoWtpappt..aPcs.hVlsps......p..s.h..tRsYsp...........sPYts................Ytt.tt..............hhsst..spp..hsshphVlult.tt...th..........Aashstltptt.......plsttslhhhhpss.ts....................................h.................................................................................t.l..t...h..hFua........s..FhPps................................	0	16	36	49
+11209	PF11377	DUF3180		Protein of unknown function (DUF3180)	Pollington J, Finn RD	anon	Pfam-B_4592 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	24.50	24.50	55.10	55.00	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.77	0.71	-4.31	30	431	2009-01-15 18:05:59	2008-08-21 11:16:20	3	1	428	0	112	293	37	137.30	29	82.88	CHANGED	LlusAlsuAlluall..lhtha.tshPs.lshhsuloLhllAllplhhAhhlRp+l.....husspptlcPltuARslsLAKAoAhsGAlluGhasGhhlalL.ptspltsuus-shsusluuluulALllAGLhLE+sC+lPs	...........lssslsuAsluahh..lhthh.sshPs.lPhhsslslhllAlsphhhAhtlRs+l...............hsssppt.lc.PhtuApsLsluKAuAhsGAllsGhahGhllhhl.tphplssstpcshsssluuluulAhssAGlaLEpsC+lP...	0	35	82	104
+11210	PF11378	DUF3181		Protein of unknown function (DUF3181)	Pollington J, Finn RD	anon	Pfam-B_4595 (release 23.0)	Family	This family of proteins has no known function.	19.70	19.70	20.70	27.90	18.40	17.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.92	0.72	-3.97	23	76	2009-01-15 18:05:59	2008-08-21 11:23:09	3	1	75	0	34	78	96	87.90	43	84.25	CHANGED	lccLsusIuD+lYlplupWHLYLGDAtLupsLA.Eshshl-pG..upsAAcpuL-ulpVslGGGpspLPLu+LlPsuQlp-LEEILEpa	..lcsLAupIG-plYIDlApWHLYLuDA.........+......LppsLAcchhshlpps...hscsslppsLcslpVtlGGG+pplPLh-LlPspphhcLh-lLEca..	0	7	23	32
+11211	PF11379	DUF3182		Protein of unknown function (DUF3182)	Pollington J, Finn RD	anon	Pfam-B_4440 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	26.00	26.00	26.70	44.20	25.40	25.90	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.98	0.70	-5.76	15	90	2009-09-11 05:33:34	2008-08-21 11:34:51	3	1	85	0	36	90	3	331.40	45	93.94	CHANGED	hVlspsscstssp..HEtsTpttLucplApLhGhpauGshc......sstptsu..sYlVPscTLVs.spAppLGlpuscDLaGGlVP+uFlATKAIoHsLspssAssPsGWopsFupplpssVLPGaosFShsDARpAut+LLtsGsVRlK.spusGGpGQpllcssspLDstLuuhssspLtspGLVLEccLcpspTaSVGQlpluGllsSYaGsQpLThsssGpcVYGGScLhVVRGua-ALLtLsLsspsRpAVppApsYDpAAttsY...PuhhASRRNYDVA....pGhDupGtsR..sGVLEQSWRlGGASuAElAALcuFppDPslptVpAuT+ElYG.-stlPssApllYRGsDspsG.LoKYsp	............h.Vlsasscsts..sp..HEhtspttlAcplApLhGhpauGthc........sshttsu..hYhVPscTLss.tpAtpLGlpuspDLhGGlVPHuFlATKuIsHPLstss.ussPtGWsttFAppltsslLsGaosFShsDAppAutpLLt.pGsVRlK.spusGGpGQhllpDhspL-thLsuhs-ptLtppGlVLEcsLppshTaSVGQlplsGhhhSYaGsQp.TtsspGpcVYGGScLhVsRGuapsLhsl.sLsp.thRtAlppAphaDpAsttsa...PuhhASRRNYDlA.......pGhDupGt.+..sGVLEQSWRlGGASuAElAALpAFttDPuLptV+AuohElYt.s..hPssAplhY+GsDspsG.lhKYh..........	0	4	13	24
+11212	PF11380	DUF3184		Protein of unknown function (DUF3184)	Pollington J, Finn RD	anon	Pfam-B_4192 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	691	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.36	0.70	-6.59	4	258	2009-01-15 18:05:59	2008-08-21 11:50:57	3	9	118	0	96	260	13	177.60	23	32.61	CHANGED	lssR....DRETDELRHSLRSVEQHVRWHRGRVVhVSPGHHPsWVDGAKNFLAGhCGuARVQALRSSGTHLRVTTVHQDAVMPYuhRLTVDSHsIEQpLWRVRNhTsVHVYMNDDYFVNRDVAITDLhNEYGGTIVRTE+GhltcGhpGssS.uoWsEGVtNTpLFNhhELDlpHEDaLPcsLl+pWpp......t.sQ.sspulhp.....hpc.lPs.............................luhschlssA....aspsshSpP..PTuhP+.R.R.....aYATHAPFVYCTNMaRaLssRYptEhAtsphp+RtRSApDLaVPFlYNAFIMARPWQASP+FLPYLhpL+puh+ttcscAh............................s..sPPhp...............IhL-N-DGCAPATLhts..ASEslauKFssNlctNcchlccVppssPLaFNINAGFooscAADQLRcFLHGhFPTPVYLE......................oSuuGsA...pptsLSRLFGDLMALPVVsVVSYEEGVCPLVRSLALAFAGHHRGGV+VpV-p+G....sAsLtEsRtsLsHRVhSAMPssACTYtcpVoVcsutRGESlAElARRAhsth....tGGVELPuTCGuGGAGLRVRGFVVDARTRusPlRSssALhcALAVPAQTLSLEDFRAVAVGPSEtDVVLVVSREDA-AKAVHWVNGASESDLLlTYPLPVEAYEDMsAEVRWS	............................................................ts...............................................................................................................................t..h...s..............Th.sS.sIE..lapl..shst.alYhNDDhhh.p.l..tphh........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t................................................................................................................................	0	54	64	83
+11213	PF11381	DUF3185		Protein of unknown function (DUF3185)	Pollington J, Finn RD	anon	Pfam-B_4606 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	21.40	21.40	21.70	25.70	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.83	0.72	-4.21	19	111	2012-10-03 00:20:40	2008-08-21 13:37:02	3	2	105	0	46	85	6	58.90	45	81.59	CHANGED	KllGlsLllsGlsLhhaGaphhsShuSphochhTGssTccshhhhlGGsVusllGlhhl	..+hIulALlVuGlVLLYFGh....QuacSlsssloRhFT........GoPo..sKTlhllsGGsVAsllGLhtl.....	1	13	27	37
+11214	PF11382	DUF3186		Protein of unknown function (DUF3186)	Pollington J, Finn RD	anon	Pfam-B_4607 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.30	24.30	24.40	24.70	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.82	0.70	-5.29	25	294	2009-09-11 00:08:05	2008-08-21 14:08:03	3	3	288	0	100	240	10	292.40	28	96.48	CHANGED	MIshRaHllSlsAlFlALAlGlllGssh............LpsslhssLpschspLcpctspLpsptpslpppssss-satstlsstllsspLsu+sVsllphssusssssculpchLppAGAsVsuplsLp-pah..sssss-clpolsss.hhssustlsptss-sus...sthlu.slh.s........stssss-csslLssLpcss..hls..hp...sssshsusssllls.......Gsssss...tsssttstslschspuLsstGtus.....Vl...sGtptousssuhluhhRu....tssVSTVDslDsshGclsshLALtptl.sGt.sGpYGsussAsulhPs	.................hIshR.HslSlsAlFLALAlGllLGush............hssslhssL...p...pphp.s..LppphspLps.ptsth.ppplssucsa.sppluspllpssLsu+sVsllph.ss.uscsDhsulschltp..AGuslsuplsLs.ppFh...sssps-pLpsllss.hhPs..GspLssphh.-tus.s..Gph..Lu.sLh.s...................................stsspspcsslLssLp..-sG...als....ap........ssthtsAsssVlls............Gss.ss........sssttstslschutuLsstus..us...................ll...sGp.t.ou.spsu....hlushRu.........sstlSTVDslDpt..sGplsshLALtp.l..sGt..sGpYGsutsApulss.................................................................	0	46	80	94
+11215	PF11383	DUF3187		Protein of unknown function (DUF3187)	Pollington J, Finn RD	anon	Pfam-B_4660 (release 23.0)	Domain	This family of proteins with unknown function appear to be restricted to Proteobacteria. These proteins are likely to be outer membrane proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.90	0.70	-5.31	18	149	2012-10-03 17:14:37	2008-08-21 14:09:55	3	2	139	0	32	161	75	297.70	39	89.81	CHANGED	hhhllhhhsshss.sssssshshuPhhshsQoPlpshtLoPpLRSuhsLssuphEhhhotohASlWu....po-phhhDY.psphsluhcaphssphplclphpahhtusspLDuhlpsFHDhFGlsQsGRscssccpaplph..s.ptGhphpsFpGcol.tuulolh....lpaplhpstpc..ulSlGuoLhasssssupFpss.uh-.ulplsauhpts.pash.......auslGhsahssspshhs....h+stshthuhGhcaphhspasLlsphchapGhh-ss..schucsSsElshGaRYhh.pssAlElullENlhNhDNSsDluFplGhRaph	....................................................................................................h...h.hhhhhhshsshssphpaGPhhsYAQuPltutuLoPpLRsGFoLP.sp.Elauuh.ohASlWu.........cossYthDaYpNQhslGl+WQhsscWQhELsYRas.AhsNpLDulThuFHDhFGlsQNGRDpVc+cRFpIsh..P.cptlthcDFsGsTL.suuholY....spYQlasscpH.....GLSL..Gu..oLYYNp..sGhhchs.....pFE..QuLQLNYoYpp..s....sHpl....auhlGl.s.a.+sssss..s....lsh+.cs...oh...s...husGYcYplsspH.pLhspa+..a.Y..QGss.-us....pEhp...cs...us.Ehl..L.GYRYhh.ssSALEluls....ENl.hssDNSTDIAhpluYRa+....................................................	0	10	20	27
+11216	PF11384	DUF3188		Protein of unknown function (DUF3188)	Pollington J, Finn RD	anon	Pfam-B_4573 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.60	24.60	25.00	24.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.14	0.72	-4.39	33	165	2009-01-15 18:05:59	2008-08-21 14:10:22	3	1	164	0	20	53	76	50.00	44	76.71	CHANGED	luAPhLIhlul.luhh...pRpGsD+ltulPsllsGh..uLllpusVsRth+R++	..NuLFLsSIGhlIlLa...ohsspsthhsL.uLsTGl..hllslGshhhh+t+K..........	0	5	9	17
+11217	PF11385	DUF3189		Protein of unknown function (DUF3189)	Pollington J, Finn RD	anon	Pfam-B_4499 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes	20.40	20.40	25.90	22.30	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.56	0.71	-4.64	23	202	2009-01-15 18:05:59	2008-08-21 14:20:44	3	2	152	0	63	128	0	145.10	44	89.91	CHANGED	hlIYpsaGGsHSSslAAuIHLspLPhc+hPspcElhplPha-php.pp-hGplhYhGpDEhGNcVYslGhts.tphltsslcshh.plhphp...ppcllllso..hlshhh+lGGahSR+htls.hGRPllshGhppsY.plsplVcpsKpp	.......................................hhIYpsaGGoHSoslAAAhHLscLPsD.Rh.oKEEILslsaFsKLp.scDhG+llFhGhDEtGN.VYolGsts.u+lVlPAh+cLh.clLppp...pEcIlhssToPsVsl.MphGGhhSRRh+lshIGhPLllaGsphshcsl.cLVphsKc.t................................	0	37	50	58
+11218	PF11386	VERL		Vitelline envelope receptor for lysin	Pollington J, Finn RD	anon	Pfam-B_1349 (release 23.0)	Family	VERL, the egg vitelline envelope (VE) receptor for lysin, is a giant unbranched glycoprotein comprising 30% of the vitelline envelope. Lysin binds to VERL and creates a hole as VERL molecules lose cohesion and splay apart. These proteins are important in the mediation of fertilisation [1]	25.00	25.00	26.50	26.80	23.60	22.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.65	0.72	-4.01	5	193	2009-01-15 18:05:59	2008-08-21 16:03:27	3	6	11	0	0	191	0	76.70	70	39.52	CHANGED	VPITRESGINMMhIHYspNcosDSPGMCVFtGPYSVPKNDTVVLYTVTARLKWSEGPPThLSIECYMPKSPV..APEPEA	......VPITpEpGINMMLIQYoRN..ch..L.DSPGMCVFWGPYSVPKNDTVVLYTVTARLKWSEGPPT.LSIECYMPKSPs..APKPE.......	0	0	0	0
+11219	PF11387	DUF2795		Protein of unknown function (DUF2795)	Pollington J, Finn RD	anon	Pfam-B_1395 (release 23.0)	Family	This family of proteins has no known function.	21.00	21.00	21.10	21.00	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.80	0.72	-4.09	58	486	2009-01-15 18:05:59	2008-08-21 16:11:08	3	5	367	0	217	407	134	44.80	39	51.93	CHANGED	L..pshcYPusKppLlppA+cssAss.c.llcsLcplP.D+c..Ysoss-V	......LpsssaPAoK--Ll-hAt+sGAs..-.Vl-sLppl..Dcs...Y-ohp-l......	0	58	141	184
+11220	PF11388	DotA		Phagosome trafficking protein DotA	Pollington J, Finn RD	anon	Pfam-B_001493 (release 23.0)	Family	DotA is essential for intracellular growth in Legionella [1]. DotA is thought to play an important role in regulating initial phagosome trafficking decisions either upon or immediately after macrophage uptake [2].	25.00	25.00	37.20	33.00	20.20	18.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.32	0.72	-3.99	2	138	2009-01-15 18:05:59	2008-08-21 16:11:59	3	1	11	0	2	137	0	103.60	83	27.67	CHANGED	FDosTGLDcSsFDPsQLTKPFGKTCQssYuLLCsWFQNKSDKLlQIQSLIsGsPALuQDGVKQPDLSssPpRt.VpGPhSSTVYGFlNNSMMVQLPGQPGIKPLT	........................................FDSsTGLDsSsFDPsQLTKPFGK.TCQGTYALLCTWFQNKSDKLVQIQSLIN.GsPALSQDGVKQPDLSPsPpRthVEGPLSSTVYGFlNNSMMVQLPGQPGIKPLT.	0	1	1	2
+11221	PF11389	Porin_OmpL1		Leptospira porin protein OmpL1	Pollington J, Finn RD	anon	Pfam-B_001515 (release 23.0)	Family	OmpL1 is a member of the outer membrane (OM) proteins in the mammalian pathogen Leptospira. Specifically, it is a porin [1].	25.00	25.00	49.90	48.90	19.00	18.20	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.82	0.70	-5.34	3	83	2009-01-15 18:05:59	2008-08-21 16:12:22	3	1	36	0	4	74	1	247.50	83	87.46	CHANGED	ITKDGLDAATYYGPVRSTDTCTVGPSDPTCVQNPuKPAGEGNYlGVAPRKAIPAENRLITLDRTTGGlINARSTKGAMVGGNLMVGYESDFGKYFFWRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKLNVTEDAAVYMGAGLNYFNGGWSLNGSNNIKGGHDILAAAGAGSVANLLSDGTDPITTREHVRFRTSGIAPNFLIGTQARVTDKGHVFLELETIMSAAYAVGKTQSlGGAsTLuPFPAYPIVVGGQI	.........................ITKDGLDAATaYGPVRSTsTCT.VussDPTCVQNPuKPsGEGNYlGVuPRKAIsAENRLITLDRTTGGhINARSTKGAMVGGNLMVGYESD..FGK.YFFWRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKL.NVTEDAAlYMGAGLNYFNGGWSLNGsNNIKGGaDILAAA...Gss..oVANLLuDGTD........PlTTREHlRFRsSGIAPNFLIGTQARVTDKGH.VFlELETIMSAAYuVGKTQShGGAosLuPFPuY...........................	0	2	3	3
+11222	PF11390	FdsD		NADH-dependant formate dehydrogenase delta subunit FdsD	Pollington J, Finn RD	anon	Pfam-B_1352 (release 23.0)	Family	FdsD is the delta subunit of the enzyme formate dehydrogenase. This subunit may play a role in maintaining the quaternary structure by means of electrostatic interactions with the other subunits [1]. The delta subunit is not involved in the active centre of the enzyme [1].	20.70	20.70	21.20	44.80	20.50	19.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.05	0.72	-3.88	52	250	2009-01-15 18:05:59	2008-08-21 16:12:50	3	2	245	0	113	242	44	61.60	45	72.72	CHANGED	+LlcMANQIusFFpo..scsculsslAsHlp+FW-PRMRcpLhsh.lp......t.uuts.LsPlVhcAl	.....+LlcMANQIusFFpoh.s+c..-AlsGlAsHIp+FW-PRMR+pLhshl-......s..uut...s..LsPlVhcAl..............	0	21	62	82
+11223	PF11391	DUF2798		Protein of unknown function (DUF2798)	Pollington J, Finn RD	anon	Pfam-B_1194 (release 23.0)	Family	This family of proteins has no known function.	30.40	30.40	30.40	30.50	29.90	30.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-8.73	0.72	-4.22	84	363	2009-09-10 17:28:17	2008-08-21 16:15:59	3	2	310	0	117	347	466	59.20	27	71.18	CHANGED	llMShhMuhl..hoslhohhsh.Ghs.s..sFhtpWhpuahlAaslAhshsl.llsPhlp+lstpls	............hhhuhhMuhl...hShlhohhsh.Ghss.....talttWh.p.uahlAaslAFsssl.llhPll++lsthh.......	0	24	71	99
+11224	PF11392	DUF2877		Protein of unknown function (DUF2877)	Pollington J, Finn RD	anon	Pfam-B_002434 (release 23.0)	Family	This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.	25.00	25.00	26.70	26.50	22.60	23.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.31	0.72	-3.85	21	929	2009-01-15 18:05:59	2008-08-21 16:23:37	3	3	528	0	50	363	13	109.10	43	39.83	CHANGED	hlGhG.GLTPSuDDhLsGhh.uhhhh.t...pshpphht.htphlths..pTTtlStphLppAhpGphspsltpLhtslhpst..spstpslcplls.lGuoSGsDhLhGlhhuhph	................hlGhG.GLTPSuDDhLoGhl.sshahsu...........tsucphptp..htp..s..ph.p.sTTtlSsthLchAhQGhhspslh+F.....lHsl.ts......t...............ps......s.pAI-...plht.lGpoSGsDhLhGhhhGppL..........	0	24	36	42
+11225	PF11393	IcmL		Macrophage killing protein with similarity to conjugation protein	Pollington J, Finn RD	anon	Pfam-B_002787 (release 23.0)	Family	IcmL contains two amphipathic beta-sheet regions, required for the pore-forming ability which may be related to the transfer of this protein into a host cell membrane [1]. The icmL gene shows significant similarity to plasmid genes involved in conjugation however IcmL is thought to be required for macrophage killing. It is unknown whether conjugation plays a role in macrophage killing [2].	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.11	0.72	-4.11	23	289	2009-01-15 18:05:59	2008-08-21 16:26:36	3	3	199	0	37	173	10	101.70	27	48.53	CHANGED	su+Ih.l.Ph-pPthspstlhsaupcslhpuashDassYcsplsphtsp.FTppGats.ahsuLppSshLcsl+sp+hslsusss..usspllppshh..tshhtWplphPlpl	...................................shppshhspsthhpauspslspuFshDa..spacppl.ssltst.aos.cGatt.ahs.AL.p.s.SsllcslKcc+h.sls.sss..Gsullsppsph....tshhhWphphPlhh...........	0	19	23	32
+11226	PF11394	DUF2875		Protein of unknown function (DUF2875)	Pollington J, Finn RD	anon	Pfam-B_002814 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	20.70	20.70	21.70	22.10	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.49	0.70	-5.92	8	205	2009-01-15 18:05:59	2008-08-21 16:27:43	3	2	67	0	20	260	0	232.10	34	83.25	CHANGED	AppuppYsLElRGlGlslsp.pQpcIW+cIccKssNauSlhSQcPcDYssS.soRps-hclsspsAFKauApcuV-YWPlPVhllGPP+shccua..RAAusIsusRppAoLGVTLFLWQ-DtNTscupuMlE+LFsFFDsHPDVPpALlhSpDGslsRshhRsPG...oss..psuphVPshPDSMsAlLVoRSDRVDRhIRPYAV-psEtlspssTpaDlsKLWNFaW-psc.....uFssaYE..AspKptGscsP.ususMSosaWQupLPsLWKTIuNKGPGpFcPSPalPVRWspWQVKpFDsAPlLGYLHRPI+VpLsD-HGKPLKsAtQAcAL+AGWtQAlsTLP-GpK.PsRVFYDTTsspthtIsLsQALHsls..upul-LuDV+EGYDIGRRl.GNTGVSSsLVQIuLAlIASYcDGGsSAsVptpssGoATIhMVSPPDtApKAttsQsp.GscPF	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	8	11
+11227	PF11395	DUF2873		Protein of unknown function (DUF2873)	Pollington J, Finn RD	anon	Pfam-B_002845 (release 23.0)	Family	This viral family of proteins has no known function.	25.00	25.00	57.00	57.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.32	0.72	-4.39	2	75	2009-01-15 18:05:59	2008-08-21 16:30:08	3	1	73	0	0	10	0	43.00	96	97.46	CHANGED	MsELTLIDFYLCFLAFLLFLVLIMLIIFWFSLElQDlEEPCsK	MNELTL..IDFYLCFLAFLLFLVLIMLIIFWFSLEIQDLEEPCTK.	0	0	0	0
+11228	PF11396	DUF2874		Protein of unknown function (DUF2874)	Pollington J, Finn RD	anon	Pfam-B_002962 (release 23.0)	Domain	This bacterial family of proteins is probably periplasmic and of unknown function.\	    There may be between one and six copies of this domain per sequence.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.79	0.72	-4.00	181	1589	2012-10-01 23:09:26	2008-08-21 16:38:52	3	9	279	21	355	1152	36	57.30	21	63.99	CHANGED	psl.shsplPss....lpstlppp..asstp.lpc....hphpp........phYclclp.......tpphclhasppGphl	.................h..hstLPps.......lpshlppp...asssp.ltc.....lcpcp........stYclcls.........sphclhFstpGphh.....	0	136	252	283
+11229	PF11397	GlcNAc		Glycosyltransferase (GlcNAc)	Pollington J, Finn RD	anon	Pfam-B_002901 (release 23.0)	Family	GlcNAc is an enzyme that carries out the first glycosylation step of hydroxylated Skp1, a ubiquitous eukaryotic protein, in the cytoplasm [1].	20.40	20.40	20.40	20.60	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.12	0.70	-5.33	25	216	2012-10-03 05:28:31	2008-08-21 16:46:00	3	11	113	0	109	246	398	269.10	25	60.42	CHANGED	oIFVslASYRDsEhhsTLcsLhspAspPcRLalGVs.Qpts..s-ss...........................................................................................................ssFhsc...........................tht.........h.tsplphhslssspu+GssaARahspthYpsEcYhLplDSHpRFl.sWDppllshlppLp.........ssKsVLSsYPsGYps...tsppphpcpsssththspF.sspGhlplp..........................uphhss.pp.ttP.....l.ssalAuGFlFucGp.Fs+-VPaDPal..hFpGEElhhosRhaT+GaDlYsPs+sl..laHhYsR.....sspsKhWs-pp....................tpWhtppppScpRsphLL..................................shtsspss........hhthshYGlGspRolspa.pauGlshtp	......................................................................................................................lFlsluuaRD...p.hh.Tl.shhppAttP.ppl.hulh.Q.....t.s.........................................................................................................................................................................................................................t..h.tsplphhphph.pupGsshARahsp....t....ha.....ts...EpahhplD.SHhpFh.tWDp.hlt.hptht.................................s.pslLotYP..s...hp...............ttt....t.p.p.h...h.hhhht.h....ttp..Gh.hphh..........................................u.t.ht..............P...........h.t..ahu.uG.a..Fupup.hhpcV.P.hDPph...hF.GEE.hhh.......usRhaTpGaDh.YsPpp..s..l..haH..Ypp.........tptsphaps.........................th....t..pphu.hpRhhhhl..................................................................................h..ht.ashGp.Rohtpa..h.sls...t..................................................................................	1	60	86	105
+11230	PF11398	DUF2813		Protein of unknown function (DUF2813)	Pollington J, Finn RD	anon	Pfam-B_002207 (release 23.0)	Family	This entry contains YjbD from Escherichia coli (Swiss:P75828), which is annotated as a nucleotide triphosphate hydrolase.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.24	0.70	-5.38	21	824	2012-10-05 12:31:09	2008-08-21 16:54:35	3	5	785	0	109	1485	191	326.10	57	61.92	CHANGED	MaLERIEIsGFRGIpRLSLslcp.sVLIGENuWGKSSLLDALSLlLss-scLYpFshpDFHhs.u.ppsps+cLpllhTFpEpc.s.-ppstRY+pl..pslWs.scs.GhcRIYYRlpuphs.sssVpTphuFLDtpGps..lslcch-pLsppLlplHPVlRlRDA...RRhtptph.tt.t.p........Rlp+clcphhRcLhspPtplsc..sEl+puLpAhppLl-HYFu.pstppsp.+ph+cp.ppsppsaph..hpslsphlcpsss..+phRllLlGllsshLpA+Gshp..Lc+tARPILLlEDPEsRLHPhMLulAWpLLshLPhQ+IsTTNSuELLS.VPLcpIpRLVRpoc+stuapLs.psLop-DhRRIuFHIRaNRstA	...............................................................................................................................................................................................................MhLERV.EIVGFR....G.I.....N.R.......L..S...L.h.L...-...........p.......N...s.....V...L..I...GENAWGKS...S...LL.D...A...L.......T.L.....L......L.......S.......P..........E.......s.....c....L.....Y......H......F...p..c...c......D.....F..a...a....Ps.....G....D......h.........p......u....+.E..+...H......L.p....I...I....L.........T..Fc......E.o...sG.....+.....a........+.s.....p..R.Y..R.sL...........css...W...........s.s.s.p.D.....G...hH...R..IaYRl..E....GE.....pu...t....D....G.......o....V....h....Th..R..o...F...L....D...p...-.....GpP.......lsl...-..c.....I.....s......c...s......+.cL....l..RL.h.....PVL....R....L...RDAR............FhRRlRs.us...s.s.N.sss.s-.........................sss+QLD...L...s......REL.ss.p..P.Q..p..L.oc.........GpI..R..Q..G.L.S...A.M.sQ.L.LEHYF......................SE....Quu.....u.....p......s..c.h.R...hh...Rc..+..s....p.s...c...pcu.W+h.............LD.I..N.RMI....c....cP.s..u..........RS.h..RlIL.....L.GLF..uTL......L.Q.AK...G..o.lc......L.c+...c..A...R.P....LL.L.lEDPETRLHP...I.M.......L.S..V....A.W....p....L.L......s........L....L........P......L....Q....R....I.....sTTNSGEL..L..S..L.s..PlE.pls..RLVRESu.R.V..AAaRL..GPsG..............LS.sEDuRRIu..FHIRFNRsSu.............................................................................................................................................................................................................................	0	15	46	81
+11231	PF11399	DUF3192		Protein of unknown function (DUF3192)	Pollington J, Finn RD	anon	Pfam-B_002991 (release 23.0)	Family	Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed.	21.80	21.80	21.80	22.40	20.20	21.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.21	0.72	-4.09	32	113	2012-10-01 23:09:26	2008-08-21 16:59:05	3	1	64	0	48	96	32	102.80	40	79.35	CHANGED	susVlhlh-ssssphs.......W-c.........+pthN+pplucLpLGt..ohspVhslhGsuDFoEAhpps.......cpplpVLFYRTp+h+uDGhTTKDECTPLlFcNspL..luWGpsu.Ypph	.........................................susVl.lh-spspths.......Wcc..ppthN+pplscLsLG...ohspVhshhGssDFoEAhtpp.......cpplpVLFYRTp+....p+SDGhTT.KDECTPLlFcNspL..luWGpsAYpph...............	0	8	20	34
+11233	PF11401	Tetrabrachion		Tetrabrachion	Pollington J, Finn RD	anon	pdb_1fe6	Family	Tetrabrachion forms a parallel right-handed coiled coil structure with hydrophobic interactions and salt bridges forming a thermostable tetrameric structure. It contains large hydrophobic cavities. No function is known for this family of proteins [1].	20.50	20.50	21.60	114.20	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.60	0.72	-4.17	2	2	2009-01-15 18:05:59	2008-08-22 10:30:29	3	1	2	8	1	5	0	49.00	100	3.22	CHANGED	IINETADDIVYRLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILAS	IINETADDIVYRLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILAS	0	1	1	1
+11234	PF11402	Antifungal_prot		Antifungal protein	Pollington J, Finn RD	anon	pdb_1afp	Family	Antifungal protein consists of five antiparallel beta strands which are highly twisted creating a beta barrel stabilised by four internal disulphide bridges [1]. A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site [1].	25.00	25.00	41.10	40.80	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.05	0.72	-3.77	6	27	2009-01-15 18:05:59	2008-08-22 10:34:21	3	1	23	2	9	23	0	52.00	53	56.43	CHANGED	ApYsGKCaKKDNhCKYKspuGKTsIsKC.s...K+Cs+DGsKCEaDSY+sKsh	l.cYhGKCTKu-NpCKYKsDpGKsslppCPphs..NKKCsKDGNpCcaDShs+......	0	0	2	6
+11235	PF11403	Yeast_MT		Yeast metallothionein	Pollington J, Finn RD	anon	pdb_1aoo	Family	Metallothioneins are characterised by an abundance of cysteine residues and a lack of generic secondary structure motifs. This protein functions in primary metal storage, transport and detoxification [1]. For the first 40 residues in the protein the polypeptide wraps around the metal by forming two large parallel loops separated by a deep cleft containing the metal cluster [1].	25.00	25.00	93.70	93.70	21.20	19.80	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.76	0.72	-3.81	2	7	2009-01-15 18:05:59	2008-08-22 10:37:10	3	1	6	6	2	4	0	40.00	100	65.57	CHANGED	QNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGN	QNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGN	0	2	2	2
+11236	PF11404	Potassium_chann		Potassium voltage-gated channel	Pollington J, Finn RD	anon	pdb_1b4g	Family	Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons [1]. Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation [1].	20.00	20.00	20.20	23.80	17.90	19.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.18	0.72	-4.16	2	56	2009-01-15 18:05:59	2008-08-22 11:11:04	3	3	29	3	24	54	0	28.50	76	4.63	CHANGED	MlSSVCVSSh.+GRKuGNKsssKsChpt-Ms	..MISSVCVSSY.RGRKSGNKPPSKoCLKEEMA...	0	2	7	13
+11237	PF11405	Inhibitor_I67	Bromelain_inhib;	Bromelain inhibitor VI	Pollington J	anon	pdb_1bi6	Family	Bromelain inhibitor VI is a double-chain inhibitor consisting of a 11-residue and a 41-residue chain. This protein is the 41-residue heavy chain which is joined to the 11-residue chain by disulphide bonds. The inhibitor acts to inhibit the cysteine proteinase bromelain [1].	25.00	25.00	298.50	103.10	18.80	17.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.45	0.72	-3.91	2	3	2009-09-25 10:05:36	2008-08-22 11:27:54	3	1	1	2	0	4	0	41.00	95	50.00	CHANGED	-EYKCYCsDTYSDCPGFCKpCKAEFGKYICLDLISPNDCVK	EEYKCYCTDTYSDCPGFCKKCKAEFGKYICLDLISPNDCVK	0	0	0	0
+11238	PF11406	Tachystatin_A		Antimicrobial peptide tachystatin A	Pollington J	anon	pdb_1cix	Family	Tachystatin A contains a cysteine-stabilised triple-stranded beta-sheet and shows features common to membrane-interactive peptides. Tachystatin A is thought to have an antimicrobial activity similar to defensins.Tachystatin A is also a chitin-binding peptide [1].	25.00	25.00	39.90	39.90	22.80	18.70	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.57	0.72	-4.10	2	3	2009-01-15 18:05:59	2008-08-22 11:36:20	3	1	1	1	0	4	0	36.30	96	82.58	CHANGED	YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQRa	YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQRa	0	0	0	0
+11239	PF11407	RestrictionMunI		Type II restriction enzyme MunI	Pollington J	anon	pdb_1d02	Family	Type II restriction enzyme MunI recognises the palindromic sequence C/AATTG. It makes contact with the DNA via the major groove [1].	25.00	25.00	85.10	84.90	18.90	17.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.61	0.71	-4.70	2	9	2012-10-11 20:44:46	2008-08-22 12:45:49	3	1	8	2	3	11	4	168.90	46	99.93	CHANGED	MGKpELpsR.sWQthuGLhuptAEpph.sVF.A.FpGTcYVlhccPKcLKslYup............NP.......paGVS.DaAIpNpcT+KhLasEIKpQ-GaV.Gcs.PpsGRGNAHERSCKhFTPGLLKshpplusl.s.thLPFWlVapGcITRDsKRsREITaWaDcYtspaFhW+ss.Sup.LlpHFpcpL++hLD	....Mupp-LptRtsWQs.SG..h..tAtsAEpshhssFptsFc...sTcYhlpp+Pp-hKslYspV.Lstp.httIasP......p........hhp......aGlS.DaAIpNpcTtKhlasElKRQDGWVEGtp..SsGRGNAHER.CKhFTPGLhcshRphutl.s.thLPFWlVh.GDITRDPpRsREIsaWappYptpaFhWRss.stpsLlpHFpp.Lh.hL......	0	3	3	3
+11240	PF11408	Helicase_Sgs1		Sgs1 RecQ helicase	Pollington J, Finn RD	anon	pdb_1d8b	Family	RecQ helicases unwind DNA in an ATP-dependent manner. Sgs1 has a HRDC (helicase and RNaseD C-terminal) domain which modulates the helicase function via auxiliary contacts to DNA [1]. 	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.46	0.72	-4.15	5	29	2012-10-03 03:05:55	2008-08-22 12:54:14	3	2	28	1	20	63	15	77.40	40	5.87	CHANGED	ElscLshuYERLRslulslGNRMNPPlssaM.PDslLKKlAshLPATE-EFlsLlGsN-ss.sRKYKYFKcTltcLRK+Rpc	.......EhsslphsYc+LRElSlslGsRMsP.P.l.ss.Fh.sDslLKKhAshLPhs-ppFspLsslpcp..pc+F.KY..FKsTlhcLp+cRp.p..............	0	1	10	18
+11241	PF11409	SARA		Smad anchor for receptor activation (SARA)	Pollington J	anon	pdb_1dev	Family	Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus [1]. SARA recruits Smad2 to the TGF-beta receptors for phosphorylation [1].	25.00	25.00	27.00	27.00	20.50	18.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.10	0.72	-4.04	3	74	2009-01-15 18:05:59	2008-08-22 13:01:21	3	6	56	3	44	72	0	40.10	79	3.24	CHANGED	uRSPNPNNPMEYCSTIPPaQQAssSP..uSPPPSVMVPVGV	...pSPNPNNPAEYCSTIPPLQQAQ.A..SGsLuSPPPTVMVPVGV.	0	8	15	28
+11242	PF11410	Antifungal_pept		Antifungal peptide	Pollington J	anon	pdb_1dkc	Family	This peptide has six cysteines involved in three disulphide bonds. It contains a global fold which involves a cysteine-knotted three-stranded antiparallel beta-sheet along with a flexible loop and four beta-reverse turns. It also has an amphiphilic character which is the main structural basis of its biological function [1].	21.00	21.00	21.60	21.30	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.43	0.72	-3.86	8	33	2009-09-11 11:38:32	2008-08-22 13:09:29	3	2	21	2	11	33	0	33.30	43	33.95	CHANGED	CIsNGutCpsDuu.ssCCSGFCap.p.PG..hshGhC+sR	.......IssGtsCptDGShG.CsSGaChp.t..s...s.GhC+........	0	1	4	9
+11243	PF11411	DNA_ligase_IV		DNA ligase IV	Pollington J	anon	pdb_1ik9	Family	DNA ligase IV along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface [1].	21.20	21.20	21.20	21.90	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.59	0.72	-4.21	7	68	2009-01-15 18:05:59	2008-08-22 13:42:40	3	9	55	4	47	66	1	35.80	55	4.08	CHANGED	ST+cHFAcEYDpYGDSYhsDTsttpL+-VFpplpss	.....ST+cHFA+EY.DsYGDSYasDTDh.sQLKEVFstI+s......	0	14	18	30
+11244	PF11412	DsbC		Disulphide bond corrector protein DsbC	Pollington J	anon	pdb_1jpe	Family	DsbC rearranges incorrect disulphide bonds during oxidative protein folding. It is activated by the N-terminal domain of DsbD, a transmembrane electron transporter. DsbD binds to a DsbC dimer and selectively activates it using electrons from the cytoplasm [1].	21.60	21.60	21.70	21.60	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.96	0.71	-4.27	187	2597	2009-01-15 18:05:59	2008-08-22 13:54:41	3	21	2012	10	617	2080	1106	118.10	24	21.34	CHANGED	pschLssppA.h..........tsssp...pltlphp.lssGaalYhcph..th.....ph.....pssssh....hsphpaPss.p...hhpD.th...ps.sYc.spltlsls..lssss............tth...plplsaQuCs-..slChPspsphhhhhs	....................................t...hl..ppA.F.hph.........ppspp....plslphp..lp.s.Gaa.lYp.cph.........h.......................ph.ssspsh.....hup.h.p.h.P.tu..p.....hh..p...D.....pha.u...p...s...phYc.sp...l.slsls....lptss......................ssh...plplsa..QGCu-...u..hCYPPpsphh....s............	0	170	352	492
+11245	PF11413	HIF-1		Hypoxia-inducible factor-1	Pollington J	anon	pdb_1lqb	Family	HIF-1 is a transcriptional complex and controls cellular systemic homeostatic responses to oxygen availability [1]. In the presence of oxygen HIF-1 alpha is targeted for proteasomal degradation by pHVL, a ubiquitination complex [1].	17.80	17.80	17.80	18.10	16.40	17.70	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-7.85	0.72	-4.77	17	330	2009-01-15 18:05:59	2008-08-22 14:00:38	3	13	102	4	83	283	0	34.00	61	4.79	CHANGED	.sspshsDLDLEMLAPYIPMD.DDFQLsslst.s.	.......s.hspshs-LDLEMLAPYIPMD..DDFQLpshs..p.........	0	4	15	35
+11246	PF11414	Suppressor_APC		Adenomatous polyposis coli tumour suppressor protein	Pollington J, Finn RD	anon	pdb_1m5i	Family	The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils [1].	22.70	22.70	23.30	23.50	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.58	0.72	-4.20	13	215	2009-01-15 18:05:59	2008-08-22 14:08:54	3	43	72	1	114	197	0	80.70	35	6.60	CHANGED	ssashL+phcpLEcE+-hLLtGL-tlE+u+-WYhsQLpslQcp.cplGphusth-hho-hppcpLshphs+lpclNcsLttLhp	...................ht.hphhcELEpE+....slLLtsL-t.E+t+-WYhs.QLpslpcRhc......pLstscs.......h...........shtoDhppcp.Lphpttplpps.cphhshh...................	0	20	29	61
+11247	PF11415	Toxin_37	Termicin;	Antifungal peptide termicin	Pollington J	anon	pdb_1mm0	Family	Termicin is a cysteine-rich antifungal peptide which exhibits antibacterial activity. A cysteine stabilised alpha beta motif is formed due to an alpha-helical segment and a two-stranded antiparallel beta-sheet [1].	25.00	25.00	41.00	41.00	19.80	16.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.18	0.72	-4.33	8	150	2012-10-01 23:31:40	2008-08-22 14:24:34	3	1	18	1	0	139	0	34.90	64	56.29	CHANGED	CsFpSCWAoCQtQHGIYFRRAaCDGSpCpCValNG	..CshppCWAsCQApHGRYFRRAYC-GShC+CVFNNG....	0	0	0	0
+11248	PF11416	Sed5p		Integral membrane protein Sed5p	Pollington J, Finn RD	anon	pdb_1mqs	Family	Sed5p interacts with Sly1p , a positive regulator of intracellular membrane fusion, allowing SM proteins to stay associated with the assembling fusion machinery. This allows for participation in late fusion steps [1].	21.30	21.30	22.70	21.40	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.64	0.72	-7.24	0.72	-4.51	11	45	2009-01-15 18:05:59	2008-08-22 14:31:23	3	1	44	1	30	42	0	28.10	50	8.41	CHANGED	h.sIpNRThEFQQsVsoYcKhN+Kpsspt	.M.sIpsRThEFQQsVhoYcKpNKp.ppp.......	0	5	17	29
+11249	PF11417	Inhibitor_G39P		Loader and inhibitor of phage G40P	Pollington J	anon	pdb_1no1	Family	G39P inhibits the initiation of DNA replication by blocking G40P replicative helicase. G39P has a bipartite stricture consisting of a folded N-terminal domain and an unfolded C-terminal domain. The C terminal is essential for helicase interaction [1].	20.40	20.40	20.80	20.70	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.42	0.72	-3.99	2	43	2009-01-15 18:05:59	2008-08-22 14:38:22	3	1	41	3	6	44	42	67.20	27	43.94	CHANGED	MI.c-slpILphlpthYP...tchpPsDhKshVphWpphLt-Y.hp.l..slpchhtsNKFPPoVu-llcA	.........................Mhcp-shcllthlpssYP....php...p...s........c..t....hlslWhphL.cDhsaphlttslcpal..t..ss.p..aPPolA-lh..p............	1	4	5	5
+11250	PF11418	Scaffolding_pro		Phi29 scaffolding protein	Pollington J	anon	pdb_1no4	Family	This protein is also referred to as gp7. The protein contains a DNA-binding function and may halve a role in mediating the structural transition from prohead to mature virus and also scaffold release [1].Gp7 is arranged within the capsid as a series of concentric shells [1].	25.00	25.00	28.00	80.70	22.70	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.27	0.72	-3.67	3	7	2009-01-15 18:05:59	2008-08-22 14:45:34	3	1	5	11	0	9	0	91.00	65	97.55	CHANGED	PLchEEHE-ILNKLsDPELscSERTEALQQLRssYGSFlSEYsELTcApEKLsAEK-DLIVSNSKLF...RQlGLTcKKEE..EcKQc-lSETITIEDLEup	.Phc.-pHE-ILNpL.DPELspSERTEALQQLRssYGSFlSEYsDLTcopEKLsAEK-DLIVSNSKLF...RQlGlTccpEE..-hKpt-lSETITIEDLEtp	0	0	0	0
+11251	PF11419	DUF3194		Protein of unknown function (DUF3194)	Pollington J	anon	pdb_1pu1	Family	This family of proteins has no known function however the structure has been determined. The protein consists of two alpha-helices packed on the same side of a central beta-hairpin [1].	21.50	21.50	21.90	22.00	20.40	21.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.77	0.72	-3.78	4	34	2009-01-15 18:05:59	2008-08-22 17:01:13	3	1	34	1	25	37	2	83.60	34	86.78	CHANGED	IGLPcLoEE-LIElG-luQ+lIIcaIF-+Lu+SEV+DlEVTsRINpGETLDLELEVYlEVPlFV+VDVEuLIDEAlDKAYculEcaL	..................h.cLsptpl.clu-hAtcsh.thlFs+l.spS-VcDl-VTlplpc...s.psLsLEl-VYlpsP.hsc.sDs-pllD-AlcpAhpsV-ch....	0	4	11	19
+11252	PF11420	Subtilosin_A		Bacteriocin subtilosin A	Pollington J	anon	pdb_1pxq	Family	Subtilosin A is a bacteriocin from Bacillus subtilis.The protein has a cyclized peptide backbone and forms three cross-liks between the sulphurs of Cys13, Cys7 and Cys4 and the alpha-positions of Phe22,Thr28 and Phe31 [1].	25.00	25.00	33.90	33.80	18.10	16.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.79	0.72	-3.92	2	17	2009-01-15 18:05:59	2008-08-26 12:13:47	3	1	16	1	2	6	0	33.70	94	77.33	CHANGED	NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG	NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG.	0	1	1	1
+11253	PF11421	Synthase_beta		ATP synthase F1 beta subunit	Pollington J	anon	pdb_1pyv	Family	The NMR solution structure of the protein in SDS micelles was found to contain two helices, an N-terminal amphipathic alpha-helix and a C-terminal alpha-helix separated by a large unstructured internal domain. The N-terminal alpha-helix is the Tom20 receptor binding site whereas the C-terminal alpha-helix is located upstream of the mitochondrial processing peptidase cleavage site [1].	20.90	20.90	22.10	39.10	20.20	20.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.61	0.72	-3.30	12	41	2009-01-15 18:05:59	2008-08-26 12:47:47	3	3	21	1	19	40	0	45.40	55	8.25	CHANGED	MASRRlLSSLLRSouR+p...uu+.......sPthssst.u......RsSPsGaLLNR	MASRRlLSSLLRSuSRtp...uu........sPthssPp..hp.....RsSPsGaLLNR	0	3	10	14
+11254	PF11422	IBP39		Initiator binding protein 39 kDa	Pollington J	anon	pdb_1q87	Family	IBP39 recognises the initiator which is solely responsible for transcription start site selection. IBP39 contains an N-terminal Inr binding domain connected to a C-terminal domain. The C domain structure indicates that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. Binding of IBP39 to Inr recruits RNAP II and initiates transcription [1].	25.00	25.00	184.80	184.10	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.34	0.71	-4.77	7	7	2009-01-15 18:05:59	2008-08-26 13:06:39	3	1	1	5	7	8	0	181.70	26	53.63	CHANGED	hcslpIhths.pppppF+ppslphWpcllp.stth.shshp.FIcthsppF...................ptspQshcN........uhpsIp.lLsspssshlThsDFhpFhAtFGP.-olhhKItphL..s.t.tpWL.h..pPph.pphs....slsuaFsps..NChlhph.sGhpa+saNhPhl.sususYLhDEssppapSWcphhp.h	..cslpIhths.pppppF+ppslphWpcllp.stth.shshp.FIcthsppF...................ptspQshcN........uhpsIp.lLsspssshlThsDFhpFhAtFGP.-olhhKItphL..s.t.tpWL.h..pPph.pphs....slsuaFsps..NChlhph.sGhpa+saNhPhl.sususYLhDEssppapSWcphhp...	0	7	7	7
+11255	PF11423	Repressor_Mnt		Regulatory protein Mnt	Pollington J	anon	pdb_1qey	Family	Mnt is a repressor which is involved in the genetic switch between lysogenic and lytic growth in bacteriophage P22. The C-terminal domain of the protein consists of a dimer of two antiparallel coiled coils with a right handed twist, which is both stronger and has closer inter-helical separation compared with those found in left-handed coiled coils [1].	20.90	20.90	25.70	34.00	19.30	17.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.69	0.72	-7.10	0.72	-4.63	3	59	2009-01-15 18:05:59	2008-08-26 13:11:58	3	2	55	6	1	38	0	29.60	66	36.09	CHANGED	RDDAERhADpQSElVKKMVFETLKDhY+K+	.DDAERhA-pQS-hVKKhVFDTLKclY+K.s.	0	0	0	0
+11256	PF11424	DUF3195		Protein of unknown function (DUF3195)	Pollington J	anon	pdb_1rki	Family	This archaeal family of proteins has no known function.	25.00	25.00	64.20	64.00	19.80	18.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.18	0.72	-3.80	4	9	2009-01-15 18:05:59	2008-08-26 13:26:27	3	1	9	2	6	10	0	82.00	44	90.33	CHANGED	alIl+TlPKKEtIVARDLCDClYYYDppVhC+slusuRVYlhTpl-hLcpCLph+YF+KLlKslElaD.Vpp.cPs.CscChllpIG-VY	...lllpTls+KEthVARDLCDCLYaa.DptVhCcsluPG+VYVpT.p.hphLcpCLsM+YFKpLlKtlElaDcVSp.pPs.ps.shh.................	0	1	2	3
+11258	PF11426	Tn7_TnsC_Int	Tn7_TnsC;	Tn7 transposition regulator TnsC	Pollington J	anon	pdb_1t0f	Family	TnsC is a molecular switch that regulates transposition and interacts with TnsA which is a component of the transposase. The two proteins interact via the residues 504-555 on TnsC. The TnsA/TnsC interaction is very important in Tn7 transposition [1].	20.30	20.30	20.70	23.30	19.30	18.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.19	0.72	-4.25	10	45	2009-01-15 18:05:59	2008-08-26 14:47:22	3	2	43	2	12	38	1	46.90	38	8.70	CHANGED	IKps-WcTLcS-DLRFlaSQssssp.shYptLcssGLlFDlpuhh+csG	....lK.s-WcoLsssDLRalYSQppspp.sha-pLKpp.Gl.IlDhpslhpt.....	1	3	6	7
+11259	PF11427	HTH_Tnp_Tc3_1	Tc3_transposase;	Tc3 transposase	Pollington J	anon	pdb_1tc3	Family	Tc3 is transposase with a specific DNA-binding domain which contains three alpha-helices, two of which form a helix-turn-helix motif which makes four base-specific contacts with the major groove. The N-terminus makes contacts with the minor groove. There is a base specific recognition between Tc3 and the transposon DNA. The DNA binding domain forms a dimer in which each monomer binds a separate transposon end. This implicates that the dimer has a role in synapsis and is necessary for the simultaneous cleavage of both transposon termini [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.24	0.72	-4.33	2	160	2012-10-04 14:01:12	2008-08-26 14:57:22	3	12	12	2	152	76	7	47.00	39	24.22	CHANGED	RGouLSDhEpu.l.sM+..ssplpEhup+lsRpRpCIpcaLKsPspYGso	...............lo..EpAplDlM.hQLG.hSlptMS+plsRSRsslcpY..lsDPlsYG..t.......	0	8	136	152
+11260	PF11428	DUF3196		Protein of unknown function (DUF3196)	Pollington J	anon	pdb_1td6	Family	This proteins is the product of the gene MPN330 and is thought to involved in a cellular function that has yet to be characterised. The proteins has 11 helices and a novel fold [1]. No function is currently known for this protein.	26.70	26.70	26.80	26.80	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.81	0.70	-5.11	5	47	2009-01-15 18:05:59	2008-08-26 15:32:04	3	3	47	1	11	28	1	224.10	27	86.95	CHANGED	Ml....KK.sshlKphsshKppFtshppl.pshpp...tN.DpLTpFFhslLpKlcsLVKcKDFKpAh-plpEELsoPYlPhsLluaFcuhhhlIs+sL.....aEsENstLAsLs+c-llsplLssaPs..sLshlcYLLsKpcsFlcss-LphhsalLTsKclh-lcKhshhpALspIssFlsppF-YYNSKLKQpFslTLscFslhtp.sopsYFsQLlcplpphFhKEPSppEFAsEIIssllVsYFPhHPsa.slscLApsIaQYVpNslpNclsshKs.ElpKlIVcslhcpLDc	.............................................h........................................ppYa--ILcplcpllcc+castAhslIspELshPYIPh.....hhppFcphhhclK+ph............h.pp.t.....sp.Lsppphhphltpshsp..plshhph.hh.+.ht.hp.....l..t..hpphL.spphtt.sKh.ll.hLt..p..IsppFphhpphhcpoh.ls.hp.s.....pt...h.pl.s.lpp..h...K.s.Pshhphsppll..hhh.haPhh..h.p.p.lAhsIhtYhppthts..hphp......p.l..........................................................................................................................	0	6	9	10
+11261	PF11429	Colicin_D		Colicin D	Pollington J	anon	pdb_1tfk	Family	Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA cleavage. It targets the four isoaccepting tRNAs for Arg and cleaves the phosphodiester bond between positions 38 and 39 at the 3' junction of the anticodon stem and the loop [1].	21.70	21.70	22.90	23.70	21.50	19.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.24	0.72	-3.83	8	39	2009-01-15 18:05:59	2008-08-26 15:48:53	3	10	37	3	7	52	0	87.90	39	12.70	CHANGED	QLpKKFK.HAsDFGlsspstNppTLscFcDsIpcHlusssTVpKGTYRptpsSKVYaNssTthsVIlcpsGsFl..SGW+lsPto-phphYlcss	.....QLpKKaK.HAsD.FGlsspptNppTL.spFccuIppHlsst..sT.lp.cGTYRt...tpsSKVaaNss.TspsVllcpsGpFl..SGWKlsPtspphp.ahps.h..........	0	3	5	6
+11262	PF11430	EGL-1		Programmed cell death activator EGL-1	Pollington J	anon	pdb_1ty4	Family	Initiation of programmed cell death in C.elegans occurs by the binding of EGL-1 to CED-9 which disrupts a complex involving CED-4/CED-9 and allows CED-4 to activate CED-3, a caspase. It is the C terminal domain of EGL-1 which is involved in the formation of the complex with CED-9. The formation of the complex induces structural rearrangements in CED-9 and EGL-1 adopts an extended alpha-helical conformation [1].	20.50	20.50	23.50	22.70	19.90	15.70	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.40	0.72	-6.46	0.72	-4.32	3	13	2009-09-11 00:00:58	2008-08-26 16:23:42	3	2	5	2	13	13	0	20.90	62	19.47	CHANGED	Y-IGoKLAAMCD-FDAEMMSY	.a-IGoKLAsMCDDFDAcMMSY..	0	2	3	13
+11263	PF11431	Transport_MerF		Membrane transport protein MerF	Pollington J	anon	pdb_1waz	Family	The mercury transport membrane protein, MerF has a core helix-loop-helix domain. It has two vicinal pairs of cysteine residues which are involved in the transport of Hg(II) across the membrane and are exposed to the cytoplasm [1].	21.20	21.20	21.50	22.00	19.40	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.13	0.72	-4.31	13	68	2009-01-15 18:05:59	2008-08-26 16:37:18	3	2	60	3	14	54	6	45.20	58	57.94	CHANGED	TPlLVILLGsVGLSAlsGaLDaVLLPALAlFIuLTlYALW++pppp	....TPlLVILLGsVGLuALsG..YLDYVLLPALAlFIGLTlYAlhR+cpt.s......	0	6	10	13
+11264	PF11432	DUF3197		Protein of unknown function (DUF3197)	Pollington J	anon	pdb_1wn9	Family	This bacterial family of proteins has no known function.	20.60	20.60	21.00	106.70	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.41	0.71	-4.07	3	15	2009-01-15 18:05:59	2008-08-26 16:40:03	3	1	15	2	9	15	0	113.80	55	85.09	CHANGED	hQAlpA+Lscl-LoEARLlLITDRQDERsQARYAALLThG+....EALLoAPAFGPAYGPuGAcALAELVRWApupGh.RspETVLSuGDFsRVLAEPDA-EV+RLlAAoNPoDPAIY	..LcALKsAL...cGl+hsEAKVhLITDWQD+R-pARYAL.LL+sGK....+cLLssDAFGPAF.PuGEcALuELVuhLlppGAR+FYEAVVSPGEhsuLL-LPPEEll+RlhAhANPTDPuIY	0	2	5	9
+11265	PF11433	DUF3198		Protein of unknown function (DUF3198)	Pollington J	anon	pdb_1x9b	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently, this archaeal family has no known function.	25.00	25.00	58.40	58.00	21.40	18.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.44	0.72	-4.09	3	4	2009-01-15 18:05:59	2008-08-26 16:42:54	3	1	4	1	4	6	4	51.00	50	41.21	CHANGED	L+DTu+FEShINSsSKSVFVRNLsELERLAKRLGKSYcIQLEpAKEKWKVK	L+Dph+FEphINSpSKphFVcNLsELEcluh+LGcuYp.pLEpAKcKWKVK	0	2	3	3
+11266	PF11434	CHIPS		Chemotaxis-inhibiting protein CHIPS	Pollington J	anon	pdb_1xee	Family	The chemotaxis inhibitory protein, CHIPS, is an excreted virulence factor which acts by binding to C5a and formylated peptide receptor (FPR), blocking phagocyte responses. A fragment of CHIPS, which contains residues 31-121 comprises of an alpha helix packed onto a four stranded anti-parallel beta-sheet. Most of the conserved residues of CHIPS are present in the alpha-helix [1].	25.00	25.00	43.10	42.30	20.00	18.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.14	0.72	-4.37	3	98	2009-01-15 18:05:59	2008-08-26 16:52:19	3	1	97	2	1	14	0	89.50	99	60.91	CHANGED	NSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY	NSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY....	0	1	1	1
+11267	PF11435	She2p		RNA binding protein She2p	Pollington J	anon	pdb_1xly	Family	She2p is a RNA binding protein which binds to RNA via a helical hairpin. The protein is required for the actin dependent transport of ASH1 mRNA in yeast, a form of mRNP translocation. ASH1 mRNP requires recognition of zip code elements by the RNA binding protein She2p. She2p contains a globular domain consisting of a bundle of five alpha-helices [1].	25.00	25.00	36.30	196.30	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.42	0.71	-4.93	6	29	2009-01-15 18:05:59	2008-08-26 17:02:09	3	1	26	2	17	23	0	208.20	61	83.75	CHANGED	-hlcpllslaSsYISsYlclLNKaIshLRRVSTLRFERsTLIKaVKKLRFaNDsLhoash.......psphshcscsLpcslpslGSaFlKsLEhlDLLNYYLTQsLQsElISKTLNpDLlls--sIssl-DTYsaFVKFoQWhlESLu...lsDsLLslEllQFolKCAlEDslDls-T-sIhLQEVhPVcsppEapsLhtpWpslLssKhut	......-llEQIlsLhS+YLSSYIHlLNKFIuHLRRVuTLRFERTTLIKFVKKLRFYNDslLSYNsp......cs-h-spuDohc.........clllPIAShFlKClEThDLLNYYLTQSLQKEIlSKTLNEDLTLosEoIlAIDDTYNHFVKFoQWMIESLp...IsosLLsLEVVQFAlKCAcEDGT........slsETDNIFLQEllPVsSEEEFpoLostWpuILcuKLss..	0	1	7	14
+11268	PF11436	DUF3199		Protein of unknown function (DUF3199)	Pollington J, Finn RD	anon	pdb_1xn8	Family	Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.	25.00	25.00	25.40	27.60	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.68	0.71	-4.27	6	44	2009-09-10 23:59:37	2008-08-26 17:06:38	3	1	38	2	7	46	0	124.00	47	96.62	CHANGED	.hITP-ELhsYSVaEpVKsRssEhLctDILEAEs-lhplsG+cFoDtch.P.....lPEplRLALL+LAQaaAhhNsDEShhKGapSEKl..GDYSYTlusus.SlsKPDVhtLLtDYl....sphstscs+h+hR	...LIsPs-lhsYSVa.-pVKsRPppLLpQDIlEAEuEhtplsGH.cFsDpsh.P......LP-cl+LALlKLAQYaALl.Nu...D....E...oshcuYpSEKl..GDYSYTlussu..ulpKP-VapLLp-aI....sths.tpsph+hR............	0	2	5	6
+11269	PF11437	Vanabin-2		Vanadium-binding protein 2	Pollington J	anon	pdb_1vfi	Family	The Vanadium binding protein, Vanabin2, contains four alpha-helices connected by nine disulphide bonds. Vanadium accumulates in Ascidians however the biological reason remains unclear [1].	25.00	25.00	39.00	38.40	19.20	18.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-11.94	0.72	-12.75	0.72	-4.00	10	14	2009-01-15 18:05:59	2008-08-26 17:19:14	3	2	3	1	8	11	0	92.40	33	55.68	CHANGED	CtspCposCssl+sC.+tpCtpsCtuspstp......hCp+sCt+spChss.......sCcsChpc.C.ht.hctCRsssCuppCP.t............tKshKsssC+cCMcpNC	..ChspCpssCssl+sC.ptpChpsCtuspp.t......hCp+sChhspC.ss.......sCcpChts.C.ht.hctC+pspCuppCP.t..........t.tpth+sssC+pCMhpNC	0	5	5	8
+11270	PF11438	N36		36-mer N-terminal peptide of the N protein (N36)	Pollington J	anon	pdb_1qfq	Family	The arginine-rich motif of the N protein is involved in transcriptional antitermination of phage lambda. N36 forms a complex with boxB RNA by binding tightly to the major groove of the boxB hairpin via hydrophobic and electrostatic interactions forming a bent alpha helix [1].	25.00	25.00	27.90	36.70	17.60	16.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.82	0.72	-4.44	2	67	2009-01-15 18:05:59	2008-08-26 17:27:41	3	1	62	1	0	41	0	34.90	97	32.86	CHANGED	DAQTRRRERRAEKQAQWKAsp.LhsshptpsspR.	DAQTRRRERRAEKQAQWKAANPLLVGVSAKPVNRP..	0	0	0	0
+11271	PF11439	CesA	DUF3200;	Type III secretion system filament chaperone CesA	Pollington J	anon	pdb_1xou	Family	This family represents a chaperone protein for the type III secretion system - TTSS - translocon protein EspA, to prevent the latter's self-polymerisation. The TTSS is a highly specialised bacterial protein secretory pathway, similar in many ways to the flagellar system, that is essential for the pathogenesis of many Gram-negative bacteria. The twenty or so proteins making up the TTSS apparatus, referred to as the needle complex, allow the injection of virulence proteins (known as effectors) directly into the cytoplasm of the eukaryotic host cells they infect; however, the injection process itself is mediated by a subset of extracellular proteins that are secreted by the needle complex to the bacterial surface and assembled into the type III translocon - EspA. EspB and EspD. EspA polymerises into an extracellular filament, and, as with other fibrous proteins, is apt to undergo massive polymerisation when overexpressed. CesA is the secretion chaperone protein that binds to EspA. CesA is dimeric and helical, and it traps EspA in a monomeric state and inhibits its polymerisation.	25.00	25.00	28.10	140.30	22.90	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.30	0.72	-4.06	2	64	2009-11-23 17:28:21	2008-08-27 09:06:07	3	1	63	3	1	15	0	91.60	95	88.57	CHANGED	MsIVpQT+NKELLDKKIRSEIEsIKKIIAEFDVlKEsVN.LSEKAKTsPQAAEpLNKLIEGYTYGEER+LYDSALSKIEKLIEThpPsRStSQ.T	M....SQTRNKELLDKKIRSEIEAIKKIIAEFDVVKESVNELSEKAKTDPQAAEKLNKLIEGYTYGEERKLYDSALSKIEKLIETLSPARSKSQST.	0	0	0	1
+11272	PF11440	AGT		DNA alpha-glucosyltransferase	Pollington J	anon	pdb_1xv5	Family	The T4 bacteriophage of E.coli protects its DNA via two glycosyltransferases which glucosylate 5-hydroxymethyl cytosines (5-HMC) using UDP-glucose. These two proteins are the retaining alpha-glucosyltransferase (AGT) and the inverting beta-glucosyltransferase (BGT). The proteins in this family are AGT. AGT adopts the GT-B fold and binds both the sugar donor and acceptor to the C-terminal domain. There is evidence for a role of AGT in the base-flipping mechanism and for its specific recognition of the acceptor base [1].	25.00	25.00	31.00	30.10	18.90	16.90	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.14	0.70	-5.57	2	14	2009-01-15 18:05:59	2008-08-27 09:18:47	3	1	11	9	1	15	23	335.00	57	79.25	CHANGED	CGVTKFSLEQRDWFIKNGHEVTLVYAKDKSFTRssuHDaKSFSIPVlLAKEYDKsLKLVNDCDILIINSVPATSVpEsTINNYKKllDNIKPSlRVVVYQHDHSsLSLRRNLGLEETVRRADVIFSHSDNGDFNKVLMKEWYPETVSLFDDIEEAPTVYNFQPPMDIsKVRSTYWKDVSEINMNINRWIGRTTTWKGFYQMFDFHEKaLKPAGhSTlMEGLERSPAFIsIKEKGIPYEYYt.+plDphplAPN.PsQILDpYlNSEMLERMSKSGFGYQLSKLspKYLQRSLEYTHLELGACGTIPVFWKSTG-NLKFRVDNTPLTSHDSGIIWFDENDMESTFERIKELSSDRA	.......CGVTKFSLEQRDWFIKNGHEVTLVYAKDKSFTRssAHDaKSFSIPVlLAKEYDKTLKLVN.DCDILIINSVPATSV.EE-.TINNY.KKIIDNIKPSlRVVVYQHDHSsLSLRRNLGLEETVRRADVIFSHSDNGDFNKVLMKEWYPETVSLFDDIEEAPTVYNFQPPMDIsKVRSTYW.KDVSEINMNlNRWIGRTTTWKGFYQMFDFHEK.aLKP.AGhSTIMEGLERS.P.AFIsIKEKGIPYEYYph+plDphKlAPNhP..sQILDpYVNSEMLERMSKSGFG...YQLSKLsKKYLQR...SLEYTHLELGACGTIPVFWKSTGENLKFRVDNTPLhSHDSGIIWFDENDMESTFERIKELSSDRA.................................................................................................................................................................................................................................	0	1	1	1
+11273	PF11441	MxiM		Pilot protein MxiM	Pollington J	anon	pdb_1y9l	Family	MxiM, a Shigella pilot protein, is essential for the assembly and membrane association of the Shigella secretin MxiD. MxiM contains an orthologous secretin component and has a specific binding domain for the acyl chains of bacterial lipids [1]. The C terminal domain of MxiD hinders lipid binding to MxiM [1].	25.00	25.00	259.70	259.40	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.70	0.71	-4.01	2	8	2009-01-15 18:05:59	2008-08-27 11:11:16	3	1	8	3	0	4	0	115.00	99	80.35	CHANGED	uSSNSEKEWHIVPVSKDYFSIPNDLhWSFNTTNKSINVYSKCISGKAVYSFNAGKFMuNFNVKEVDGCFMDAQKIAIDKLFSMLKDGVVLKGNKINDTILIEKDGEVKLKLIRGl	SSSNSEKEWHIVPVSKDYFSIPNDLLWSFNTTNKSINVYSKCISGKAVYSFNAGKFMGNFNVKEVDGCFMDAQKIAIDKLFSMLKDGVVLKGNKINDTILIEKDGEVKLKLIRGI	0	0	0	0
+11274	PF11442	DUF2826		Protein of unknown function (DUF2826)	Gunasekaran P, Mistry J	anon	Pfam-B_001753 (release 23.0)	Family	This is a family of uncharacterised proteins that is highly conserved in Trypanosoma cruzi.	20.20	20.20	22.50	22.50	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.43	0.71	-4.57	2	60	2009-09-11 10:16:18	2008-08-27 11:20:43	3	1	2	0	2	60	0	131.00	79	68.08	CHANGED	pRERtRE.LLL.LASLLPhVASHADYh..ADHGWCASTSDVVCRHFTAPVKHTSRRMLWLWIWCRtCSRHhFARLLFTALR.IDASP.ESFsAAPCVVLstphohll................Csh.LTV.tpsVhhp+s...+pRhasshhtCspaspuphlt	...t..cRERE.LL.LLLAS.LLPFVASHADYCLSADHGWpASTSDVVCRHFTAPVKHTSRRMLWLWlWCRcCSRHYFARLLFTALRQIDASPPESFTAAPCVVLPAQ.ShVVhRLsDupsPLRWsMQGCGLPLTVLGTAVWMR+P...HERMYCGphKCVKYAESQhLQ...	1	0	0	2
+11275	PF11443	DUF2828		Domain of unknown function (DUF2828)	Gunasekaran P, Mistry J	anon	Pfam-B_001814 (release 23.0)	Domain	This is a uncharacterised domain found in eukaryotes and viruses.	29.00	29.00	29.20	29.40	28.00	28.80	hmmbuild  -o /dev/null HMM SEED	534	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.85	0.70	-6.30	19	303	2009-01-15 18:05:59	2008-08-27 11:21:35	3	3	139	0	139	295	228	343.40	21	87.77	CHANGED	TENsusTahoS....ssssLDhFhplss.pss..........cplhsLhttAWs....cDs.hslKllhplRslR.sG+u-+pu...FhpshhaL.tcp..aPpTlttN....................................................hpplspaGha.KDlhpllhphlc.....................................................................................................................................................pshcLauctLtpDhp.lt..tt..............hpplSLAAKWsPo.spphsctshhsptlut..........................hthsccchRK.sLsPLR+tLplsEhhMuA+pWsplsYs+VsSlAMtpYpchFh++DspR.............FptYLpslppGc.......sKlsAuulhPa-llpphhs.sspst......................A-hQWcshscplpppGp..lpNslAlsDVS.....GSMsu............PMcVsluLGLLlSEh..sssPa+sclITFSpsPphcpl..pGc.sLt-+sphlpphsWG.hsTshptVF.-hILpsAlcspLs.-cMl+clFVFSDMEFDpAssttt................................hcTsaEslpc+apcsGYt..lPclVFWNLpsssu...sPVsuscpGVALVSGFStslh+hhLps...........................................phsPhshMh..................................culs	.....................................................................................................................h......t.....t.h...h.....s................h.....................................................................................hGhh.c.h...........................................................................................................................................................................................................................................................huKh...........................................................hpt.....hp....h.-..ht.t...........h..h.a...st.s.........hF..p...t.....................h...a..th..t...................h..t........h...h.............................................................................................................................p.hsh.shs.....tp................h..s.uhshhhst....t..att.hh.att.......h..................t.........h..........thph.tsh.p.ll.........uht..th......t.hhlhoDh.hp.s............................................................t.h...a.t.t.s.......h.........PphlhWslt.............................h........sh.hhsG.s.thht.h.t...........................................................................................	0	40	86	114
+11276	PF11444	DUF2895		Protein of unknown function (DUF2895)	Gunasekaran P, Mistry J	anon	Pfam-B_002001 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.60	22.60	22.80	50.90	21.60	22.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.18	0.71	-5.10	26	239	2009-01-15 18:05:59	2008-08-27 11:22:14	3	3	191	0	62	214	10	196.20	50	89.80	CHANGED	+ptlsspcpHIhoLRlshuhLsllhlshhhuhhpAPpcLslHlPPDLRu.GSTRph.....W-VPspsVYuFuaYIFQQlNRWspsGcpDYtpsIt.tLpsYLTPuCpshLppDhc.RtpsGELppRsRsVa.EIPGRGYusp....+VhlhopcsWsVpLDlsscEhap...uEsVK+sl.lRYPL+VVRhDlDsE+NPaGLAlDCYsus.PpRl	................ptlsptpsHIpTLRlusu...hLsllhlshshGWhpAPccLTIHlPPDLRS.GSTRhW....WEVPPpoVYuFuaYIFQQLNRWPpsGEpDYspNlp.pLusYLTPuCpsaLppDachRpssGELRpRVRslY.EIPGRGYu-s..........+VpshSpcsWhVpLDlsuDEYat........uE.VKRAL.lRYPl+VVRh-lDPppNPFGLALDCYsus.PQRl.................	0	8	29	50
+11277	PF11445	DUF2894		Protein of unknown function (DUF2894)	Gunasekaran P, Mistry J	anon	Pfam-B_001968 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	59.20	59.10	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.78	0.71	-11.41	0.71	-4.05	44	142	2009-01-15 18:05:59	2008-08-27 11:23:51	3	2	136	0	46	157	12	178.40	44	83.45	CHANGED	LDAW....REpGADRLDPVRF+hl-ALpRRAAApsGsARcLLDsRLAsLl-uYAsplpcApsssssspss......................................................sussstPA+GsLAuLlchlu...+p.......A.scpRus..............sth..hsE.c....hL.DY...................FRcT...WS+lss-pQlRQSL-QVP+NAGPLNSSsLVHRSLoLMRELSPcYLpQFLSYVDALSWLEQhsuss	................................L-AWRppGADRlDPVRF+hl-ALt+RAAupsGtsRplL-sRLusLlcuYAttlppstsssts.t...............................................................ss......ssstsspusLusLlp.lu.................u.sthht............................................ssth.hhsE.t....hL.Dh...............................FRco...Wo+lps-pQlRQSL.ppVPcNAGPLNSssLVHRuLsLMRELSPtYLppFLSYVDALuWLEQhsuts.................	0	7	21	34
+11278	PF11446	DUF2897		Protein of unknown function (DUF2897)	Gunasekaran P, Mistry J	anon	Pfam-B_002015 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.70	21.70	22.50	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.79	0.72	-4.14	32	221	2009-01-15 18:05:59	2008-08-27 11:24:52	3	1	220	0	49	148	6	61.10	35	93.54	CHANGED	.shpsWlIIllVlGVIsuNLAsLKaoA+hKhsphsc.hpphppps........t.cppsst-	..........apsWlIlllVluVIVGNlAsLKaTAp.hKhsph.-cppcpsc.pt..........t.........t..............................................	0	7	14	34
+11279	PF11447	DUF3201		Protein of unknown function (DUF3201)	Pollington J	anon	pdb_1yb3	Family	This archaeal family of proteins has no known function.	25.00	25.00	26.60	38.10	24.00	22.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.01	0.71	-4.80	4	14	2009-01-15 18:05:59	2008-08-27 11:29:45	3	1	14	1	12	17	0	150.90	53	88.93	CHANGED	EFLN+hWE-sFcLREEL+EELc..GFcVEEVsEVFNAYLYlDGcWcEMKYPHPAFsl+PGGEVGATPQGFYFVFAFsKE-LocEFlccFlcsFcK.SFIYGhENFLEDFYN...ssPhSh-EVac+IhpScEchINFEVDhshs+EELK+cLh+.F	.....paLN+hWt-lFcLpEELKEELp..GFcVE-VEEVFNAY.IalDGEWccMcYPHPAFplKPtGEVGATPpuaYFVhAlsKEc.loc-FlptFlctF.+.SFIYGuENFLpDhYN..ccsPhsscEVhccIccScEclhpFEsshs.sh-cLKctLh+...............	0	2	2	7
+11280	PF11448	DUF3005		Protein of unknown function (DUF3005)	Gunasekaran P, Mistry J	anon	Pfam-B_3492 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	45.50	45.50	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.45	0.71	-4.47	11	108	2009-01-15 18:05:59	2008-08-27 11:30:58	3	1	68	0	27	98	3	119.10	48	72.35	CHANGED	usssRRAssR.lpLDNssTc..DsTVDTDGKshEAA+hAotht...DplhhSNASLsNAls-ss-G..lAGhDSRPGGNpPtlAhRsGapVlcpGhlsss..........................sspGpRsp+VIplpcs	..........ssstRAtsR.lpLDNssTt..DsTVDTDGKshEAuRhASth....DplhhSNASLsNAhPEssDG..hAGhDSRPGGN+PtlAhRsGatVlccGhssss............................st.s.pRst+llplp.s..	0	2	5	15
+11281	PF11449	DUF2899		Protein of unknown function (DUF2899)	Gunasekaran P, Mistry J	anon	Pfam-B_002023 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	24.40	24.40	25.80	24.50	22.80	24.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.94	0.70	-5.24	19	285	2009-01-15 18:05:59	2008-08-27 11:31:55	3	3	211	0	48	243	397	219.80	29	79.21	CHANGED	AAlhGAlPGCGGAllVsotassGpluFGAlVAVLsATMGDAAFLLLAspPpsulh..llsluhllGlloGhlVshhatcch..h+st.tptsttspts........................pthphthh........ha.hlllPuhllulh..tuhpl-hsphh.th.thslthhGshh.uh..hhlWAhop.htshpshsspssth....p....lp+ssp-TsFVosWVlsAFLha-lslthsGl-..LtshatthuhhhPLIullIGLlPGCGPQIlVToLYlsGslPhSulluNuISNDGDALFPAIAluPKuAlhATlYoulPAllVGYGaYal	.............................uullGslPtCGhulhsss.ahpthlshGsllAlhhuT.s-Ah.lllutt..s...hshh..lhslthlhuhlsGhllshh.hht.h...hp............................................................................................................................................................................................................p.p.ptth.......t...htpuh.tcT.hl.salhhshhhhphhhhhhG.-..lss.htthuhh.PhhuhhlGhlPsCusplllTpLY.lpGslshuu.hushlossGsuLhshht.hs.....ct.t.h..hpl..hs...l.....Ahhluhshh...........................................	0	18	29	42
+11282	PF11450	DUF3008		Protein of unknwon function (DUF3008)	Gunasekaran P, Mistry J	anon	Pfam-B_3521 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.50	21.50	22.00	45.70	19.00	18.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.69	0.72	-3.83	21	166	2009-01-15 18:05:59	2008-08-27 11:37:14	3	1	163	0	47	105	274	57.50	69	82.60	CHANGED	AKSKAQQ+AAGAALuAKRG-scpS-L+GAS+pMh-SMSEKELE-hAST++KGKPcHts	.AKSpAQQKAAGAALuAKRGEhKhSELpGASKpMa-SMoEKELEEhApTKRKGhPpHhS........	0	12	24	32
+11284	PF11452	DUF3000		Protein of unknown function (DUF3000)	Gunasekaran P, Mistry J	anon	Pfam-B_3481 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	41.60	41.50	18.10	18.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.02	0.71	-5.03	38	408	2009-01-15 18:05:59	2008-08-27 11:38:31	3	1	407	0	108	282	65	181.80	45	89.57	CHANGED	upPstF+cAVsAMpAsslRPEIcLGsIRPP.QRLAPaSaALGA-Vp....cs-...t.hstpu-ssAFGRLILLaDPsGs-AW-GT.hRLVAYlQADLDss.AsDPLLPEVAWSWLs-ALcuR..ssphsALGGTVTuTTSVRaG-IuGPPcAaQlELRASWTAos.....s.DLuuHVpAFs-VLppsAGLP..PtG....VTcL	..........h.Ps.FppAlpuhpu..s....p...hRs-lcltpI.sP.pRLAPaShA..luu-..Vs.....ts-.................................-s.AhGRLILLHDPsGp-AWp......G........T.hRlVAalpADlDsuhAsDPLLPcVAWSWLsDuL...............-u+.............sss.......apAluGTVTussStpFGsluus.....PcupplElRASWTsss.............................DluuHlpAas-lLtpsAGLP...Psslss...........	0	35	80	100
+11285	PF11453	DUF2950		Protein of unknown function (DUF2950)	Gunasekaran P, Mistry J	anon	Pfam-B_002484 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	20.20	20.20	22.20	23.30	20.00	19.50	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.56	0.70	-5.41	42	260	2009-01-15 18:05:59	2008-08-27 11:39:24	3	3	231	0	69	187	20	245.90	54	89.42	CHANGED	QpsFsoP-tAspAhssAlss..sDpssLtplLGsshccllssss..hsppshtcFlptapppH..pl.tc.....scscAhLtVGsssWshPlPlVKpusG.WpFDstAGpcEllsRRIGRNELsAIpshhAYlDAQp-YApp...ttstshcYAQ+llSosGK+DGLYWssss.GcstSPLGPhhupus.tpsh..........spsYaGYaaRILs.uQGssAsGGthsYllpGphhtGFALlAWPAcYGsTGVhoFhVspcGpVYp+DLG.cTsphApshppFsPD..tsWphV	........................................................................................QppFsoPEsAAsAFusA..lAs..psEspLssLLG-DWRpaLPs-G..sDs-uVsRF.RDW+cuHcIVpc......-ssAaLsVGc-sWpLPlPhVKcssG.W+FDhAAussEILTRpIGRNELuslQAh+AYVDAQpDYhhp.......sp+aApRIISS-GpKDGLYWPocs..G.-...........sPSPLGPsFSsAu.................ss-GYHGY+FRIlo.spssc...................GhALlAWPh+YG-TGVMSFMVNQDcclYQuDLGc-Tcu+spAITcFsPD..spWQs..............	1	12	25	46
+11286	PF11454	DUF3016		Protein of unknown function (DUF3016)	Gunasekaran P, Mistry J	anon	Pfam-B_3517 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	27.30	73.70	23.20	19.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.70	0.71	-4.60	32	121	2009-01-15 18:05:59	2008-08-27 11:41:40	3	2	116	0	55	121	21	139.00	37	77.50	CHANGED	sG....tVpVpapcPcpapDlc.tusthpsphcpphhppLscplschAp+hLsssQpLclplTDlDLAGchcP......ttss.s-lRlV+-laPPRIshsYpLh.psGpVltp.Gcc+LsDhuF.hppsshhss...csh.tYE+phLsDWhccp	..............G.VpVpWp-PppFpDl+..osptpsthcpchhppLspphpc.As+.LssGQpLclslTDlDLAGchcP...........htusshsDlRlV+.DIYP.PRIshsYpLh.tsG+Vltp.G-c+LsDhuF....h.s.hs..thss...-sh.tYEKphLsDWh+cp..	0	13	29	42
+11287	PF11455	DUF3018		Protein  of unknown function (DUF3018)	Gunasekaran P, Mistry J	anon	Pfam-B_3532 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.30	21.30	21.40	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.16	0.72	-4.04	24	130	2009-01-15 18:05:59	2008-08-27 11:42:13	3	1	117	0	50	103	9	63.50	43	76.54	CHANGED	stpRV++HR-+LRstGLRPVQIWVP.DsRsPpFtsEsRRQsthlsp.-tp-sclhtFl-cs.sDh.......-sW	.........s.ppRVp+aR-pLRttGLRPlQIWVP.DsRpPcFstEs+RQutLVAt.ctt-s-..sFlDts..sDh.-s........................	0	10	21	37
+11288	PF11456	DUF3019		Protein of unknown function (DUF3019)	Gunasekaran P, Mistry J	anon	Pfam-B_3539 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	50.70	50.60	24.20	19.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.55	0.72	-3.70	30	88	2009-01-15 18:05:59	2008-08-27 11:47:29	3	1	49	0	36	69	8	100.50	29	77.97	CHANGED	LploPchCls.ccupsCphslplpWQsss.tshClh.sppsh.hhCapssppsphslphcsspslpFhLhcpcssps....LAssplcVs.s..hpsR+RhRssWsL	..hploPchCls.ccspsCphslplpWQtspstphClh.sppph.hhCapstpptphshphcsppshpFsLl....s.pcsspsLApsclcVs.s..hpsR++hRssWsL...	0	4	13	24
+11289	PF11457	DUF3021		Protein of unknown function (DUF3021)	Gunasekaran P, Mistry J	anon	Pfam-B_3526 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	23.10	23.10	23.10	23.20	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.96	0.71	-4.28	33	949	2009-01-15 18:05:59	2008-08-27 11:48:11	3	2	811	0	85	479	2	136.00	30	95.57	CHANGED	M.....h+phlptshhGlslGhhl.llhhhh.ts.....psshss..p.hlshh....................llGhlhuhhohIFcp..-chSlhtphlhHFhsshhshhshshlss.Wh.ht...shlhhhlh..Fl.llYllIWhhhahphppclc+INppL	.................................................M.....Kphhp.s.hh..h....G.lhIGhhls....llhs..hlhsst.....hs.hsshos.........hhp.hh......................hIGhlash.us.hlFch....pc.aS...h.hp.t...slhHFhlh...hssals...l...uhlsG.WF.Phph....hhlhhhlh..Fl.llY.ll.IW.hIhahpptpplcpINp.L..............	0	17	41	63
+11290	PF11458	Mistic		Membrane-integrating protein Mistic	Pollington J	anon	pdb_1ygm	Family	Mistic is an integral membrane protein that folds autonomously into the membrane [1].The protein forms a helical bundle with a polar lipid-facing surface. Mistic can be used for high-level production of other membrane proteins in their native conformations [1].	22.30	22.30	22.40	134.60	20.30	18.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.58	0.72	-3.58	3	23	2009-01-15 18:05:59	2008-08-27 11:50:52	3	1	23	0	3	19	0	84.00	77	88.55	CHANGED	MKVTDQEKEQLSsAID+MNEGLDsFIpLYNESEKDEPLIQLEDETAELl+cApEpYGp-clNpKLNAIIKEILS.lSLc--GcEc	MKVTspEKEQLSsAIDRMNEGLDAFIQLYNESEhDEPLIQh-D-TAELh+QARD.YGQEpLNEKLNTIIKQILS.ISLScEGcc....	0	1	1	2
+11291	PF11459	DUF2893		Protein of unknwon function (DUF2893)	Gunasekaran P, Mistry J	anon	Pfam-B_001947 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.00	22.00	23.60	38.50	20.70	19.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.01	0.72	-4.18	32	244	2009-01-15 18:05:59	2008-08-27 11:53:01	3	2	227	0	72	189	24	65.70	41	26.50	CHANGED	SsPERAlLEhLsclscppoh.ccscplhpGLssLRPchLppLLppCpulKspRLFhhhAcctsHsWtp+L	........SsPEhAhhEllssls....pthSF.EcsspLhpGLssLpPctlppLLppspSVpspRLFLahAchhsHtWhpcl......	0	13	39	62
+11292	PF11460	DUF3007		Protein of unknown function (DUF3007)	Gunasekaran P, Mistry J	anon	Pfam-B_3514 (release 23.0)	Family	This is a family of uncharacterised proteins found in bacteria and eukaryotes.	25.00	25.00	33.60	40.10	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.21	0.72	-3.95	30	109	2009-01-15 18:05:59	2008-08-27 11:58:10	3	1	100	0	54	107	95	98.30	43	74.84	CHANGED	MsRhcVlh....IGlulhllGGluYhshp.hhGl-uhsAGIhupulLVlsl.luWsuSYla..RVloGcMTahpQR+cYccsa............LQcRh-uLosEEhptLht-lpp	.MpRhDVlh....IGlGlhlhGslhYhsLp.hhGlDuhpAGhhuQs.lLVlG.l.luWluoYlF..RVsspcMTYtpQh+-YEcth............lpKRl-pLo.-ElptL.t-lE..........................	0	16	38	50
+11293	PF11461	RILP		Rab interacting lysosomal protein	Pollington J	anon	pdb_1yhn	Family	RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes [1].	21.20	21.20	21.30	21.30	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.03	0.72	-3.82	14	188	2009-01-15 18:05:59	2008-08-27 12:46:05	3	2	72	1	109	162	0	59.20	43	18.62	CHANGED	TLQELR-VLpERNcLKuplhllQEELthY+st.hppcpt......sss..t.....t.hsphppEsst+	...TLQELR-VLpERNELKuplhlLQEELthYK..s.....p.hppcpt............st....h.....p.hsp.p.tp.................................	0	21	29	59
+11294	PF11462	DUF3203		Protein of unknown function (DUF3203)	Pollington J	anon	pdb_1ywy	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	87.60	87.40	20.00	17.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.28	0.72	-4.07	5	34	2009-01-15 18:05:59	2008-08-27 13:11:16	3	1	34	1	9	28	1	74.00	55	97.07	CHANGED	Msl-IDs...sopsCslslEss+c+usssslcItTDuEtRMSVlsl-GcRlaITEsEADALTVAGAsDuRRHLKADD	MoIEIDs...ppthColplEGsRc+u..sls..sl+IsTDsEtRhSVlhlDGcRlaIoEp-AptLsVAGApDpRRHLhADD.	0	2	2	7
+11295	PF11463	R-HINP1I		R.HinP1I restriction endonuclease	Pollington J	anon	pdb_1ynm	Family	Hinp1I is a type II restriction endonuclease, recognising and cleaving a palindromic tetranucleotide sequence (G/CGC) resulting in 2 nt 5' overhanging ends [1]. HINP1I has a conserved catalytic core domain containing an active site motif SDC18QXK and a DNA-binding domain [1].	25.00	25.00	27.40	27.00	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.22	0.71	-4.92	3	24	2012-10-11 20:44:46	2008-08-27 13:12:27	3	1	23	6	3	21	5	187.10	54	83.72	CHANGED	MGYDL-cIEpVKAsVLSG.YKADVNVlILVphK..csLDlcNIQVKLVSNp+GFNQIDKRWL+oYQEMWNFPcNIYcILpYFTGELcPp+pcsK.DKRRMFhsEFSQEEQsclLDWL--NKlLILoDILKGRG-FAAEWVLVIQKlsNNh+WlLKNINEVlQHY.suG-VplSP+GSLKIGRVTIQRKGGDNGRESANMLQFKIDPTcLL	...............MGYsLspIcpVKAslLsG.YKADINl.lhlhhK..pslDlcNIQVKLVS.N.p+GFNQIDKRWlKsYpEhWphscsIhplLpYFTGELp......t.sp+RhhhsEFoppEQ.hlLsWFppNKlLlLoDIL+GRG.-FuAEWhLVhQ.Klsp.N.+WsLKNINEVlQHY..ssG-V.ISP+GSL.KIG+...lThQRKGGDNGR.oANMLQFKIDPsELh.......................	0	1	2	3
+11296	PF11464	Rbsn		Rabenosyn Rab binding domain	Pollington J	anon	pdb_1yzm	Domain	Rabenosyn-5 (Rbsn) is a multivalent effector with interacts with the Rab family.Rsbn contains distinct Rab4 and Rab5 binding sites within residues 264-500 and 627-784 respectively [1]. Rab proteins are GTPases involved in the regulation of all stages of membrane trafficking [1].	20.60	20.60	20.80	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.88	0.72	-4.39	6	155	2009-01-15 18:05:59	2008-08-27 14:31:52	3	5	98	4	111	146	0	41.40	48	9.63	CHANGED	LLQQIsNI+uYI+QA+tutRhDEVcsLpcNLRELQcEhtcQQ	.........LLQQIpNIcuaIcpA+pssRhDEVcsLpcNLRELpcchtpQp......	0	25	38	74
+11297	PF11465	Receptor_2B4		Natural killer cell receptor 2B4	Pollington J	anon	pdb_1z2k	Domain	2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells [1]. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.36	0.72	-4.13	4	44	2012-10-03 02:52:13	2008-08-27 14:39:07	3	2	25	6	18	121	0	106.40	44	31.50	CHANGED	CsDSuEEVVGVSGKPVpLRPSNIQTKcVSlpWKKph..SHsphc.IlsWsNsuspssshsSSDIYGF-scsFALSIKSAQLQDSGHYLLElTspsGpVCTKNFQlLIhD	........................C.sSu-cVVulSGpPlpLp.Ps..slQTK.h.h.S..lpWKhph.....Spsphc.I..LpW.cNsus...sp........s...s............s...c....pau..F.p....hc....shuL.....IKuAQ.QDSGhYhLElTs.psGpV.pstpFQV.lFD................	0	1	1	3
+11298	PF11466	Doppel		Prion-like protein Doppel	Pollington J	anon	pdb_1z65	Family	Dpl is a homologue related to the prion protein (PrP). Dpl is toxic to neurons and is expressed in the brains of mice that do not express PrP. In DHPC and SDS micelles, Dpl shoes about 40% alpha-helical structure however in aqueous solution it consists of a random coil. The alpha helical segment can adopt a transmembrane localisation also in a membrane [1]. The unprocessed Dpl protein is thought to posses a possible channel formation mechanism which may be related to toxicity through direct interaction with cell membranes and damage to the cell membrane [1].	25.00	25.00	27.40	27.40	18.20	17.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.19	0.72	-7.10	0.72	-4.38	7	74	2009-09-11 05:32:31	2008-08-27 15:40:05	3	1	51	1	14	79	0	29.70	73	16.75	CHANGED	MRKHLGshWLAllChLLhScLSsVpARGIK	....MRKHLGGCWLAIVCVLLFSpLSuVKARGIK	0	1	1	2
+11299	PF11467	LEDGF		Lens epithelium-derived growth factor (LEDGF) 	Pollington J	anon	pdb_1z9e	Family	LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure [1].	24.00	24.00	24.30	24.80	23.50	23.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.24	0.72	-4.34	9	180	2009-01-15 18:05:59	2008-08-27 15:40:40	3	4	78	27	106	162	0	106.50	42	20.50	CHANGED	EccLQ+LHsEIK.uLKlcssDlcKClcAL-ElusLpVTophLQKNs-slsTLKKIRRYKus..................QslMcKAstlYs+FKshFl.scsEohhshs.phsppEpc.p-pscp	.........-p+LQ+lHu-IK.uLKlDssDVp+CLpAL-ELusL..QVTpQhLQKpo-hlsTL.KK......IRRaKus.......................................p.slM-KAshlYs+aKshFLhscs-sh.st..shs.ts.t-pttcc.t..p.....................	0	19	25	69
+11300	PF11468	PTase_Orf2		Aromatic prenyltransferase Orf2	Pollington J	anon	pdb_1zb6	Family	In vivo Orf2 attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during naphterpin biosynthesis [1]. In vitro, Orf2 catalyses carbon-carbon based and carbon-oxygen based prenylation of hydroxyl-containing aromatic acceptors of synthetic, microbial and plant origin [1].	22.00	22.00	175.70	175.40	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.80	0.70	-5.20	12	25	2009-01-15 18:05:59	2008-08-27 16:02:56	3	1	21	8	8	28	0	292.20	28	93.44	CHANGED	hDhp+hhuslctsAthlssPhu+cpshslLssFp-sFsp..Gslla+sss..phssplsYRahs..sh.DshuhAlstGLl.scssHPlssLlschssLhs.ssp.usDhssstGhpKhWsaFss..hpsluclhulPuhPtulttptchFtchGL.-+VphlulDYpp+ThNlYF....tutGslstppstuhh+.sGhssPup....thltaspc.....uaslhsTLsa-oucI-Rlsahshph...sssphPA.lpsclc+F...lcssP.t..tph...shuhsausptcYlKhps.Yphshsphhsh.s.tshs	...hshschhuslccsAthlssshu+cpVhslLssFp-sFsp..uV.lhaRsTo..psscsLsaRFh.s..ssh.DPhuhAlspGLl.scssHPlusLls-lpshhP.hsttulDFulspGhpKsWsaFss..hpsluclhulPuhPtultsptchFt+aGL.-+VphlulDYpp+ThNlYF.......hssGshstcslpuhlp-sGhs...sPop....phlthspc.....uaslYsTlsWDSscIcRlsasshsh...sst...slPupl..pspl-+F...scsAPhtspscp..hlhuhuhus....pscYhKlps.Yphp.h.h.........s..............	0	2	4	7
+11301	PF11469	Ribonucleas_3_2	DUF3204;	Ribonuclease III	Pollington J	anon	pdb_1ztd	Family	This is a family of archaeal ribonuclease_III proteins.	25.00	25.00	155.20	155.00	23.90	17.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.47	0.71	-3.90	3	14	2012-10-03 08:45:47	2008-08-28 09:06:36	3	1	14	2	12	17	0	118.40	62	88.42	CHANGED	KGLAKLGDSLINFLaSLALTEaLGKPTG-RVPNASLAIAL-hoGLSKll+PRsDKHAKGDhAEALlAYAWLcGpISpEEAVEILppNLss-VhcFoRKKEsIG+ALAsLh-hIuERLsuc	KGLuKFGDSLlNFlaSLALoEaLG+PTGsRVPNASLAIAL-hAGLp+hl.PRsDKHGKGDhAEAlIAYAWLEGtITlEEAVEIl+pNhopDVhcFSRKKEAIGpAhA.LL+lIuERLs..h.	0	2	2	7
+11302	PF11470	TUG-UBL1	TUG;	GLUT4 regulating protein TUG	Pollington J	anon	pdb_2al3	Family	TUG is a GLUT4 regulating protein and functions to retain membrane vesicles containing GLUT4 intracellularly. TUG releases the GLUT4 containing vesicles to the cellular exocytic machinery in response to insulin stimulation which allows translocation to the plasma membrane [1]. TUG has an N-terminal ubiquitin-like domain (UBL1) which in similar proteins appears to participate in protein-protein interactions [1]. The region does have a area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein-protein interaction site [1].	23.30	23.30	23.30	24.30	23.20	22.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.69	0.72	-4.05	28	216	2012-10-03 10:59:06	2008-08-28 09:53:01	3	9	197	1	158	213	3	62.90	38	12.64	CHANGED	sls.ss+ptplKVosusslppVLppuCcKaslcss.....casLp+ps.Kh....lDLSLsaRhusLsssu+LEL	...........slssstRRtplKVoPsp.hLhpVLp-u..CpKhs..lsss.......pasLK..app..Kh....l.DLSlsaRhusLsssA+LEl......	0	41	75	126
+11303	PF11471	Sugarporin_N	DUF3205;	Maltoporin periplasmic N-terminal extension	Pollington J, Coggill P	anon	manual	Domain	This domain would appear to be the periplasmic, N-terminal extension of the outer membrane maltoporins, Pfam:PF02264, LamB.	21.60	21.60	21.60	21.60	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.00	0.72	-4.32	19	821	2009-01-15 18:05:59	2008-08-28 09:54:01	3	6	505	0	61	363	7	58.20	36	11.80	CHANGED	Mp.phh.lslhslLhhssh.....tAhAstLTlEQRLtLLEccLppscpELppscpchpc.hcp	..................pp..luhhlhL.hssss....shpu.hA.p...p.L..T......lEQRLtLLEpcLppsc.pchpcscsch+p.hh.p......................	0	4	15	34
+11304	PF11472	DUF3206		Protein of unknown function (DUF3206)	Pollington J	anon	pdb_2au5	Family	This bacterial family of proteins has no known function.	23.60	23.60	23.60	243.30	22.70	23.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.73	0.71	-4.36	2	13	2009-01-15 18:05:59	2008-08-28 09:57:28	3	1	13	1	2	3	0	128.00	91	94.76	CHANGED	IlSTpKtPNFpYp-.hcpFL.NhLAFohGhhTtDhSpFsP.VLt.MEc-PsWLpEusuhhQullVtSLl-stNassstpLhsEhspLlpLY.thtpcpLTpNp-sLalslaDKFhhLLLssDEhIh.L	IISTNKAPNFQYTDEMDRFLMNTLAFSVGLVTEDYSTFDPEVLKIMEEEPDWLQESVAWCQSLVVGSLVDSGNYDDTGELMDEFNCLLNLYDRARQRELTSNEDNLFLNIHDKFLALLLTDDELITNL	0	1	2	2
+11305	PF11473	B2		RNA binding protein B2	Pollington J	anon	pdb_2az0	Family	B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex [1].	20.50	20.50	20.70	21.20	20.40	19.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.56	0.72	-4.39	2	10	2009-09-11 16:34:22	2008-08-28 09:58:13	3	1	6	6	0	12	0	74.50	55	62.45	CHANGED	M.SKLALIQELPDRIQpAVEsshuMSYQ-APNNVRRDLDNLpACLNKAK.TVsRMVTSLL-KPShsAYLEGKs	............SphtLlQ-LPc...pIQpAVcsAhuhshpssPspVt+DLDNh+ACLsKhctTshRhssSLLsKPpVVAhLcGcA..	0	0	0	0
+11306	PF11474	N-Term_TEN		Telomerase reverse transcriptase TEN domain	Pollington J	anon	pdb_2b2a	Family	This is the N terminal domain of the protein telomerase reverse transcriptase called TEN. The TEN domain is able to bind both RNA and telomeric DNA and contributes towards telomerase catalysis. The TEN domain has a structure that consists of a core beta sheet surrounded by seven alpha helices and a short beta hairpin [1].	25.00	25.00	417.10	417.10	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.42	0.71	-4.91	2	2	2009-09-11 09:41:36	2008-08-28 10:51:22	3	1	2	3	1	3	0	188.00	100	16.91	CHANGED	INNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNN	INNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNN	0	1	1	1
+11307	PF11475	VP_N-CPKC		Virion protein N terminal domain 	Pollington J	anon	pdb_2bai	Family	This is the N terminal domain of a family of virion proteins which contains a zinc finger domain. Currently no function is known.	21.10	21.10	81.60	80.60	20.50	17.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.72	0.72	-4.41	5	30	2009-01-15 18:05:59	2008-08-28 11:34:25	3	2	7	1	0	33	0	32.00	93	1.67	CHANGED	MATTMEQEICAHSLTFEECPKCSALQYRNGFY	MATTMEQEhCAHSLTFEECPKCSALQYRNGFY	0	0	0	0
+11308	PF11476	TgMIC1		Toxoplasma gondii micronemal protein 1 TgMIC1	Pollington J	anon	pdb_2bvb	Family	TgMIC1 is released as part of a complex by Toxoplasma gondii prior to invasion. The complex which consists of TgMIC4-MIC1-MIC6 participates in host cell attachment and penetration and is critical in invasion. This is the C terminal domain of TgMIC1 which has a Galectin-like fold which interacts with and stabilises TgMIC6 providing a mechanism for an exit from the early secretory compartments and trafficking of the complex to micronemes [1].	25.00	25.00	29.50	252.00	19.10	17.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.57	0.71	-4.64	2	5	2009-01-15 18:05:59	2008-08-28 11:35:37	3	1	3	2	3	5	0	137.00	66	29.94	CHANGED	chclhGDShpAhLctGQQLhlTa.SspLcVuVGSCHpLssNF.DhaLpFpTsSpSu.D.VEl--sAGsu.LTIGLGppGRlsVVhpYsp.suu.t.sAYsVtDSGCpo.EtV.hpGlssGApLVhsTlG-sssu.St	KTEIHGDSTKATLEEGQQLTLTFISTKLDVAVGSCHSLVANFLDGFLKFQTGSNSAFDVVEVEEPAGPAVLTIGLGHKGRLAVVLDYTRLNAALGSAAYVVEDSGCSSSEEVSFQGVGSGATLVVTTLGESPTAVSA	0	2	2	3
+11309	PF11477	PM0188		Sialyltransferase PMO188	Pollington J	anon	pdb_2c83	Family	PMO188 is a sialyltransferase from P.multocida. It transfers sialic acid from cytidine 5'-monophosphonuraminic acid to an acceptor sugar [1]. It has important catalytic residues such as Asp141, His311, Glu338, Ser355 and Ser356 [1].	25.00	25.00	28.50	39.90	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.21	0.70	-5.64	4	21	2009-01-15 18:05:59	2008-08-28 11:52:36	3	3	19	18	3	32	0	347.70	37	81.47	CHANGED	TlElYlDhAoLPoLpQhhchIQpp--h.ss.RlhuhuRasIssshlsc..hNhpFa..hsN+spstllstL.DphstspphhplplahNhhHulsll.sIhshh.pt.cKloh.cLsLYDDGStEYVsLaphpchs-hppp..Iptpcs.LtphLssspsphsNshhsRYsWpplasopYHhLptDaF-pp..LpsLKchLupshppMcWstasphsspQpshahsllGFssEh.ppQhhts.pssFIFTGTToasus.-hh-hhAQQQlslLNctppssSshalG..psYcLaFKGHPsushlNchIhsph.shIpIPApIsFElLhMTshLPDpVGGhASSlYFolPs-plN+llFhoSDp.p.+p-hLsss....LlpVMlpLsIlsEs	............................................lplYlD.AoLPsLpQhhchhpppc-h.pp.RlhuhuRatls-s.lpp...Nh.phh.hhsN+ss.....ptLhshl.cphsts...lplclahNhuHShplltPIhthh.pths+lpIppLsLYDDGShEYVcL.p.pcstshptp.............lptucppLpphL.ssp.phsN.shhspYsWpphaPspYHhLppDYF-pt..LpsL+cYLupshppMcWssapp..LospQpshahslVGFs.sEh..pphhpsppssFIFTGTToapus.c.h-hhAQQQlNllNchhptpushalG..spYclaFKGHPp..uu.lNchIhssh.shhpIPApIsFElLhMTGh.LPDpVGGlASSLYFSlPpE.KlsaIlFToscp.p.+cDhLpss....hlpVMhpLsIlccp.........	0	0	1	2
+11310	PF11478	Tachystatin_B		Antimicrobial chitin binding protein tachystatin B	Pollington J	anon	pdb_2dcv	Family	Tachystatin B is an antimicrobial chitin binding peptide and consists of two isotopes B1 and B2.Both structures contain a short antiparallel beta sheet with an inhibitory cysteine knot motif. Tyr(14) and Arg(17) are thought to be the essential residues for chitin binding [1].	25.00	25.00	106.00	105.90	18.70	18.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.35	0.72	-4.23	2	2	2012-10-01 22:06:18	2008-08-29 08:54:07	3	1	1	2	0	2	0	42.00	95	100.00	CHANGED	YloCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF	YloCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF	0	0	0	0
+11311	PF11479	Suppressor_P21		RNA silencing suppressor P21	Pollington J	anon	pdb_2cwo	Family	P21 is produced by Beet yellows virus to suppress the antiviral silencing response mounted by the host. P21 acts by binding directly to siRNA which is a mediator in the process. P21 has an octameric ring structure with a large central cavity [1]. 	28.90	28.90	29.00	351.60	21.10	28.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.10	0.71	-4.53	2	5	2009-01-15 18:05:59	2008-08-29 08:55:10	3	1	2	4	0	6	0	173.80	91	100.00	CHANGED	MKFFhpDGETSRAlSRSESLLRRVKELGTNS.QSElSEClsEFNELApFNHLLVTVEHREWMEpHPpQSScLRsPSRlGEMLKEIRAFLKVRVVTPMHKETAS-TLNAFL-EYCRIsGLsREDALREKMRKV+SsVLFHHSELLKFEVTENMFSaTELLKLNLSLRVISSQILGhAl	MKFFhpDGETSRAISRSESLLRRVKELGTNSPQSEVSECINEFNELARFNHLLVTVEHREWMEKHPKQSSELRsPSRLGEMLKEIRAFLKVRVVTPMHKETASETLNAFLEEYCRITGLTREDALREKMRKVRSTVLFHHSELLKFEVTENMFSFTELLKLNLSLRVISSQILGIAV	0	0	0	0
+11312	PF11480	ImmE5		Colicin-E5 Imm protein	Pollington J	anon	pdb_2dfx	Family	Imms bind specifically to cognate colicins in order to protect their host cells [1]. Imm-E5 is a specific inhibitor protein of colicin E5. It binds to E5 C-terminal ribonuclease domain (CRD) to prevent cell death. The binding mode of E5-CRD and Imm-E5 mimics that of mRNA and tRNA suggesting an evolutionary pathway from the RNA-RNA interaction through the RNA-protein interaction of tRNA/E5-CRD [1].	25.00	25.00	31.30	31.30	20.60	17.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.64	0.72	-4.16	5	26	2009-01-15 18:05:59	2008-08-29 08:55:51	3	1	21	2	5	23	0	78.30	50	81.21	CHANGED	MKLSsKAAIEVCpcAAK+GLsIu+IEGGIWHpP..GFEARlDsIWDGhDsPlDh.oclscNNppAtEsI+-D.SsGHDAFIVTlsu	..........MKLSsKAAIEVCpcAsK+GLhIhtI-GGhWhsP..GFchc.ss.Ws..hD.P.ch..splscNNplAhEsI+-DhpsGasAFIlTlt...	0	0	2	4
+11314	PF11482	DUF3208		Protein of unknown function (DUF3208)	Pollington J	anon	pdb_2ebe	Family	This bacterial family of proteins has no known function.	25.00	25.00	104.60	104.30	16.80	16.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.52	0.72	-3.92	4	19	2009-01-15 18:05:59	2008-08-29 09:07:12	3	1	19	6	13	20	2	107.40	58	95.15	CHANGED	htAVRLhQGYLWHP+uhslDLcuhLPtEls..........sA+lLWDpVsPPhsFFEsGpPTtoQpFYQhTlLhlh-E.P..EuL+s.AEtAupALG.lLEGhPPGVGW.LhEDLRsL	....hpAVRLhQGYLWHP+-hslDLcshLPtEls...........sA+lLhDpVsPPhsFFEDGTPTtoQpFYQlTlLhls--tP..-uL+PhAptsupuLsslLEuhPsGVGW.LhEDLRsL.	0	3	8	13
+11315	PF11483	DUF3209		Protein of unknown function (DUF3209)	Pollington J	anon	pdb_2ehw	Family	This family of proteins has no known function.	25.00	25.00	25.70	82.10	23.90	22.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.55	0.71	-3.78	5	29	2009-09-11 16:33:41	2008-08-29 10:10:54	3	1	29	4	14	28	0	122.20	47	99.94	CHANGED	MoCHEIEALRLGLMNVLGTsD-uARpHAccELEGcL..cGPIEALAEA-oLAAlcRHLDAALVDLEEElAAT-c--PEYDYLRGRLVAVRDAEpALpRLsscGEAlLsDLGEoHcsLHEsFPVDE	MuCaElpALRLGlMNlLGhcD-ssppHtcpELtstL....pGPIcuLA-AcoLsulpRaL-uALlDLEEclAst-s-DPchsYhRGhLlAV+csEtpLppLptpu-ulhcDLsEhHchLHEhFPscc.	0	4	10	13
+11317	PF11485	DUF3211		Protein of unknown function (DUF3211)	Pollington J	anon	pdb_2ejx	Family	This archaeal family of proteins has no known function.	21.60	21.60	22.30	22.80	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.62	0.71	-4.13	11	43	2012-10-02 19:24:03	2008-08-29 10:24:31	3	1	17	1	16	38	2	130.40	35	98.28	CHANGED	M.chplpIpTsH-h-ulhpILSDPpFslPplhPshKplp.hpssoFpu.Gc....ahhhsach+Gslalu.sclsYsaplsss.................sstGsG+Lphsh.ppsclplplEY-GhhE+h.u.shlc+hlpchtccl-EcIRhERIKRKI	....M..phsh.TpHDhpslhcILSDP.Fhl.tlLss.cplp.spsspFcs.ss.....huhhsllhpGshYlGss.ploYshphttt...................ssuG+lphph.pcs...cIplhl.-a-Ghhtphst.hhlpp+lpchhcph-EclRLERIKRKI....................................................................	0	2	2	14
+11318	PF11486	DUF3212		Protein of unknown function (DUF3212)	Pollington J	anon	pdb_2euc	Family	Members in this family of proteins are annotated as YfmB however currently no function for this protein is known.	21.50	21.50	24.40	23.40	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.69	0.71	-4.35	4	24	2009-09-10 16:55:32	2008-08-29 10:36:29	3	1	24	2	5	22	0	116.00	57	76.49	CHANGED	MaYFSPEQQaNAWlVSDLVKQlFp+cstppssh+cLssFAEc+F+IsIDaVFSIIhNIGDIEp.hlsp-hEchLSSYLssLhPaVTtDMhcsS+pNAppYL.+E+ssDVY+LFhs.sshhph	.........hpYFSPEQQaNAWlVSDLVKQlF+++stCssGI+ELssFAE-+FHIsIDFVFSIIhNIGDIE..sLspEIEspLSoYLouLhPhlTADMhcoSKsNAatYLp+E+ss-lY+LFh..sshhph	0	1	2	3
+11319	PF11487	RestrictionSfiI		Type II restriction enzyme SfiI	Pollington J	anon	pdb_2ezv	Family	SfiI is a restriction enzyme that can cleave two DNA sites simultaneously to leave 3-base 3' overhangs. It acts as a homo-tetramer and recognises a specific eight base-paid palindromic DNA sequence. After binding two copies of its recognition sequence, SfiI becomes activated leading to cleavage of all four DNA strands. The structure of SfiI consists of a central twisted beta-sheet surrounded by alpha-helices.	25.00	25.00	206.60	206.30	18.30	17.30	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.74	0.70	-5.22	2	6	2012-10-11 20:44:46	2008-08-29 10:52:14	3	1	6	4	3	7	0	235.80	54	95.61	CHANGED	hcpcYhc.s.-clEplEKpTLRhlVQAl.pYppcAppIFEppss.sSs....luEDITp.ALEhhtha.IspRhhGhIDYKpspaL.pPchhl.QsLhVDuKAppttsps.TLQhSQlsM..chRpppSGcslshputl.P...L.phNDs...hlTToIFV+a.YR....VpuR.+ELpSIhVhulPpuhLpppYNPDsssohahAG+cuPsRtEhhRlRl.FDRLKctssWRlQ.l.hssDs.a....W..........st	..........LppsL-+LEEIEKsTLRLVVQAIYDYRcpAlEIF+cEuDLsSD....IuEDITREALDRLGMsRIDpRLFGKlDYKRACYLFHPDYAl+QALFVDSKAEKsuspu.ATLQhSQLSM..tV+QpRSGpsVslpGchPT...lIolcsp..+YLTTTlFVKYNYcc....-uts+pLKSIlVAAVPNGhLQDRYNPsPpDTIWtAGRNAPohGE-FRVRLSFSpLKcKAAWRVQsIPMPP-s.a.....................	0	2	3	3
+11320	PF11488	Lge1		Transcriptional regulatory protein LGE1	Wood V, Coggill P	anon	Charwan C	Family	This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B.  This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters [1]. In S. pombe the equivalent protein to Lge1 appears to be Shf1.	21.80	21.80	21.80	22.20	21.10	21.30	hmmbuild  --amino -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.64	0.72	-3.79	20	157	2009-01-15 18:05:59	2008-08-29 11:04:03	3	1	85	0	81	150	0	100.90	37	32.56	CHANGED	sPal.............tlhplc.............Dpspppc..............lcptap-hs......plDpcLcpLptphh+hE.hphshLpspsp+-uLpVQLT.pEK........L-shhhh	...........................................................................................................................s.ah..............h.ch-ttsp............Dpsppsc.....................lpsRsKAIs......oKsKEIEpVY+QcsETFGMVVKMLlcKDPsLE+sIQhsLcpN........L-Elhh.....................	0	7	20	48
+11321	PF11489	DUF3210		Protein of unknown function (DUF3210)	Wood V, Coggill P	anon	Charwan C	Family	This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is Swiss:O94497 and the Saccharomyces cerevisiae member is Swiss:P40563.	17.50	17.50	22.90	20.60	17.00	16.60	hmmbuild  -o /dev/null HMM SEED	711	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.48	0.70	-5.84	15	113	2009-01-15 18:05:59	2008-08-29 11:05:14	3	5	100	0	90	116	0	597.80	28	77.07	CHANGED	P+IPPRP.s+Rh-RSsSP....ssaAPSPLN-.s.............ptp.s.p...sPpRPsSV.slPSlGEEGtEYpslsssshoss........soPsp..oRsVusDL+LHAP+PSlPsuoAKu+lpAVTRTDSppAsAsGhG.tsuuPttcshtcpsocSLpspsosopssSusspstp..Sht..s-EHGI.PEIGQpVPM.hsNAGDVQAPSPuPhp.............pt.tptHtRppSuRt..uLPPGSYGLHGHGl.ss-+FEKAaYEKHP--hs+E-pupatsslGpsRs.DaAlSuDDLN+IV+toAspGsGLus..thsuTPpEplGahAs-EhopRhuoPsPcSsp.................hcsPl+.p..s.t...............................hIHlDpPh+p...............tp..tt.sttt.s.......-pPILAuD.....EVphcsuhpp...PAVSPohc+c............p...ptp..SsscSRssS+ssshptshst.hc...........psPLEDVcEYEPLFPED-pcsh.ctshspss..........................+.c.+sp.hp++FPSpDlWEDoPsShphp.usVSTP-..................tpcshEsPcQpssRcoptsshcs.....................pps.....psc.....ptpcstsRsph.pQRFPS...RDlWEDuPESppLsTTlpss...................................--hpspSPtss.sKPslPu..RPp...+.............s.csttps.s.spcc+pPPslPsRP..................KPQIPARPuKstsppsu-.......pstp.s............sKsKPsVPuRPtGSKIAA..L+AGFluDLNuRLpLG........PQuPp+.....ppppct...............ppptsssEKuPLSDA......RKGRARGPtRR+PAst...............sst+hsshsplshspsassWpls	.............................................................................................P.lPsRP..pt..ps..s............SPhs.......................................+..s...h..hs.p..-ht.....................s.p...t.htp-..h.AspPslPstpsptph.sVTps-sp.utthh.....s.s...t.........................................t..t...................tpcpuI..plu.pVPh...phGsVQAPoPus.t.................t.p.p..St......Psuohuh+sHt......psth-pshhpKHPc.hth.pts...........c..phuhSspcLNclV+pst......s...t..usPp-pluh.t.-chspRhsss.sts................................................................lHlc...p.........................................................t.............................ptPlLAsD.....Elt.pst..t...PAlsPthtpp...........................u.s...ps...+.ps+s....t.....s....t........................ttslcclcEhEPLF..---tp....p...tttp.................................................................p....p.........pcFPS..pDlWE...D.sPsuhphp..spVoosc...........................t..psPt....pt.tppppt.t.p...................................t.......t.t.p...tt.c..t........pp+..FPS...+DlWEDs.P-Stphtsplp.s.......................................pp..t.pss..t....pp.P..tlPt...RPp..................................................s.p.s.....t..s...ttp+tsPslPc+P..................KPp..lPsR.sp.tpppstp.........p....s...................s+sKPslPsR.P....s..GuK.....IAA..lpAGFhscLNs+LpLG............Ptssp...........tpp.t....................................pttp.tc.+..sPLu.DA......RKGRARGPtRRtP..sh...........s...ssstc..hstssp.hph..shshWpl............................	0	15	45	72
+11322	PF11490	DNA_pol3_a_NII	DNA_pol3_alph_N;	DNA polymerase III polC-type N-terminus II	Finn R, Coggill P	anon	Pfam-B_853 (release 23.0)	Domain	This is the second N-terminal domain, NII domain, of the DNA polymerase III polC subunit A that is found only in Firmicutes. DNA polymerase polC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria [1].  Purine asymmetry is a characteristic of organisms with a heterodimeric DNA polymerase III alpha-subunit constituted by polC which probably plays a direct role in the maintenance of strand-biased gene distribution; since, among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased [2]. It has been predicted that the N-terminus of polC folds into two globular domains, NI and NII. A predicted hydrophobic surface patch suggests this domain may be involved in protein binding [3]. This domain is associated with DNA_pol3_alpha Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF14480.	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.30	0.71	-4.48	63	1162	2012-10-02 15:09:17	2008-08-29 11:09:41	3	24	1157	0	139	793	71	115.20	23	8.07	CHANGED	sYappllpphsp.tssshpshLpppphph.cssclh.lhstschhtshl+ppthshlhpphhphGFs....hphpsplpp.p.spp.h....ppappp+tpc-p...phspp...shpphpppppptpppppp	............pYappslppsst..to..s..hh+uh.hppppsph..ps.spLh.l.sssslppsahccpt.hsslhcpapphGFs.....phphphchsc.t.s....ppph.............psactpppppsp...ptspp...........Ahcthcphcttts..tp.p........................................	0	44	85	113
+11323	PF11491	DUF3213		Protein of unknown function (DUF3213)   	Pollington J	anon	pdb_2f40	Family	The backbone structure of this family of proteins has been determined however the function remains unknown. The protein has an alpha and beta structure with a ferredoxin-like fold [1].	20.30	20.30	21.30	86.90	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.01	0.72	-4.11	2	12	2009-01-15 18:05:59	2008-08-29 11:11:46	3	1	12	1	9	16	0	87.70	47	91.88	CHANGED	h.lKF.ssls.EcApIhQYELppc-chaRlFlNsYA+su.VlhD-phhshEEL...hEcLKsEVltEKplTlQELIEtShSWNNVh.S+u	.l.pl+F.GpIs.EEAphhQYELppctuVaRlFlNGYA+sGhVlFD-pplscEclLchLcchcPEVlpE+clTlpELIEpShSWpNlh....t..	0	1	1	6
+11324	PF11492	Dicistro_VP4		Cricket paralysis virus, VP4	Tate JG, Finn RD	anon	pdb_1b35	Family	This is a family of minor capsid proteins, known as VP4, from the dicistroviridae. The dicistroviridae is a group of small, RNA-containing viruses that are closely structurally related to the picornaviridae. VP4 is a short, extended polypeptide chain found within the viral capsid, at the interface between the external protein shell and packaged RNA genome[1].	22.60	22.60	23.40	40.80	22.30	20.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.83	0.72	-3.96	11	50	2009-01-15 18:05:59	2008-08-29 11:12:18	3	7	19	1	0	54	0	57.20	45	6.17	CHANGED	uusEhpps....GsIScsAosVuplAssls..plPllGshA+s....spWlustVuslAplFGa	......soEssp.....GsISclAouVssVANsl-..pIPllGpIAKP....lpWVushVusVAulFGa	0	0	0	0
+11325	PF11493	TSP9		Thylakoid soluble phosphoprotein TSP9	Pollington J	anon	pdb_2fft	Family	The plant-specific protein, TSP9 is phosphorylated and released in response to changing light conditions from the photosynthetic membrane. The protein resembles the characteristics of transcription/translation regulatory factors. The structure of the protein is predicted to consist of a random coil [1].	25.00	25.00	43.60	43.40	21.10	20.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.78	0.72	-3.43	5	29	2009-09-11 09:35:24	2008-08-29 11:52:16	3	1	16	1	15	31	0	77.20	43	68.38	CHANGED	AT+G.GoAss+EEKuhhDalhGhlhKcDQhhETDPlLpKVDtKuPSGSTsu+KAsu+uPAsSA.....Ac-EGGsGGFsLGuLFAK	..........stt.tuusucEEKGlhDaIhGtlhKc-Q.h.lETDPlLpKV-pKs.u.Gs.....osup....Kus..ssustpts......tcccGGsGG.....hG...GLFuK...	0	1	7	11
+11326	PF11494	Ta0938		Ta0938	Pollington J	anon	pdb_2fqh	Family	Ta0938 is a protein of unknown function however the structure has been determined. The protein has a novel fold and a putative Zn-binding motif. The structure has two different parts, one region contains a beta sheet flanked by two alpha helices and the other contains a bundle of loops which contain all cysteines in the protein [1].	22.80	22.80	22.80	23.00	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.33	0.72	-3.92	4	21	2009-01-15 18:05:59	2008-08-29 13:09:29	3	1	20	1	8	17	1	99.50	61	93.18	CHANGED	M...KIlVNG+EAGTKEKGCALCGuTWGDYYE-lDGE+LFFCCDICAhEFlNMlsEVKK+TuWs+lDELlINGNY.pGRsC.uKsGs+ch+FYVKFs--AsIcTF+.hs	.....MKIlVNG+EAGTKEsGCALCGGTWG.DYYEEIDGEKLFFCCDlCA.LEFVNMlNEVKKRTsWSRIDELlI..NGNYYTGRTCsAKsGs+EYKFYVKFNDDAsIETFKEls..................	0	3	4	7
+11327	PF11495	Regulator_TrmB		Archaeal transcriptional regulator TrmB	Pollington J	anon	pdb_2f5t	Family	TrmB is an alpha-glucoside sensing transcriptional regulator. The protein is the transcriptional repressor for gene cluster encoding trehalose/maltose ABC transporter in T.litoralis and P.furiosus [1]. TrmB has lost its DNA binding domain but retained its sugar recognition site. A nonreducing glucosyl residue is shared by all substrates bound to TrmB which suggests that its a common recognition motif [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.31	0.70	-5.39	30	611	2012-10-02 13:01:53	2008-08-29 13:10:22	3	5	362	2	163	568	67	147.60	19	52.42	CHANGED	tl.hl+uhpsllpphp-lIpsAcpElhluls.chLcplpctLhsuhccGVpVhLllhs.....sss.s.hchhsssstlRhpcsss.shl....lluDtppulhsspp........pscscpYulhhpcpsLhhhlsthFhsshWtpuphlh...spshshPhpasshRhulpslpphhppuhslpuplpGhshp.oscphslpGcl..ss.............hsthst.hsshhlcoscu.plsVGGhsAhlEDlEupplplptt	....................................h.lhsl+uppsllpphpplIppAcpcl.hl....u.....s....h....p....-.....l.....p.p.....l....c...s....t.....LppstccG..Vplh.hl..hhs..............hpssh.p..h.c...h....h...t.h....s.p..............s..c..ht..tt..t..c...hh.l..................lssDs.cchlhu.s......................ppp..u..hhs...p.....hhhhh.............................................................................................................................................................................thhh.....................................................................................	0	39	99	140
+11328	PF11496	HDA2-3		Class II histone deacetylase complex subunits 2 and 3	Wood V, Coggill P	anon	Chahwan C	Family	This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-12.01	0.70	-5.60	26	146	2012-10-05 12:31:09	2008-08-29 13:22:22	3	6	101	6	102	1604	22	269.30	22	34.08	CHANGED	sssu-ahlPssMsphQK-Lh-pllslatpsIlca.h...cspspppsh.................................pphchhhpphphlusHP..L.Ll-HaMP+ph........hht-.stchttoSuKFtlLscLlshl..............pppp......................hpllllscssKph-LlEulLhG.....+tlphpRhsuphlhscs+chs............................................................................................t.thusslaLhsocslhpp..sss..tp.phshlIuhDssl-spsPslpplRppptp................................................t............sPllRLlshsSsEHhtLpasp.....tt.p.h.th..t.......................LRchlGslssD...shslhpp..lchlssal	.........................................................................................................................t..stcahlPhshsthpK-hh-pll.s.h.ctps.lhca..h...........csp.s..pps.h...................................................................................................pph..ph..h..hpplp.lssHP....L...l........l.....-....H.h..h..Ppph......................................................h.t..c..........s.....t......p....h..t...t..s..SuKFphLppLl.shl.........................pphp......................hcllllscs.s+phDLlEuhl..lG...............pphp..hpRhsu..p..p..h.hsp.ppths............................................................................................................................................................................thshtlp.L.h.ss.p......thhp..........p.s.....phsh.lIshDs.s..h.......-spt..ssl...phlcppt.pp...................................................................................t.hPll+Lls.soh-HhtLhhsph.........pp.p..l..phhtt.......................hps.hGpl.ss....h....p..................................................................................................................................................	0	21	53	89
+11329	PF11497	NADH_Oxid_Nqo15		NADH-quinone oxidoreductase chain 15	Pollington J	anon	pdb_2fug	Family	This protein, Nqo15, is a part of respiratory complex 1 which is a complex that plays a central role in cellular energy production in both bacteria and mitochondria. Nqo15 has a similar fold to Frataxin, the mitochondrial iron chaperone. This protein may have a role in iron-sulphur cluster regeneration in the complex. This domain represents more than half the molecular mass of the entire complex [1].	25.00	25.00	26.50	114.90	19.00	17.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.51	0.71	-4.40	3	17	2009-01-15 18:05:59	2008-08-29 13:32:55	3	1	17	15	11	16	2	127.70	62	96.40	CHANGED	MAsAs-ccLYcQWVELLGWLc-EApoRGLuFEKVADFPDYIYRMERPYDLPTTVMSVuLSsG.GQPLLLAAVSPRHVDLKGISLRLMGGSKHWHLHA...Gu+GLLEGKRPFTRERLuVLLDGAhRGlAsV	......Mutup-ctLYcAWVELLuWM+EYApt+.GVpFEKEADFPDFIYRMERPYDLPTTlMoASLSDuhGEPFLLAsVSPRHAcLK+IuLRL..s+tHhHLHA..EsG+G.L.l.sGKlPLTKERhasLADRARculuh.....	0	3	7	11
+11330	PF11498	Activator_LAG-3		Transcriptional activator LAG-3	Pollington J	anon	pdb_2fo1	Family	The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12 [1]. Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1 [1].	23.30	23.30	23.70	24.90	22.50	23.20	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.93	0.70	-5.74	2	17	2009-01-15 18:05:59	2008-08-29 13:48:28	3	5	8	1	16	20	0	259.40	31	60.52	CHANGED	MKPSTSK...ospSPPPEEPsusaVNspLPsP-DEPhlu-hssappGpE.tR.RSp.AhtpapKsR.E.IusQRAVTApLapRaTEDEERKRhEpQKNKEAMNASsu..ouSRNG..pl-NRKRRND..Vus.ouEEEW+RA.QQQHWMGQttP.h.paQMQQQYH.QQQ....httQHHphh................u.+SVPTP.uShHpPSPutMpssC...................PhsDENsLsVPpGEWFDKLAlhVAEpYsssTILGPDTYDsaLsELDh.ps.u.ThpoP.Ehs.....poAs.P..NPQp.tQhtQQQNKMRhhQQQp.....hEQQRpQQhMpQpQQQ....HppQQMLL.QQQQ.pQhQQppQMN.GGQF.TQApQpAsYhQpMQ+M...pQ.ppQQQQAQpHQQA.QQHQQ.tQpt.MGYulPNGY.tp.phasP.YG.HHMPp.TsFANIN	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..ppQ...QpphhhhQQQp............p.hppQR.pQQh.Qtp...Q....p.pp.QQh....p.......ppt..........pt...psshhp.....h..pph...p...................................................................................................	0	4	5	16
+11332	PF11500	Cut12		Spindle pole body formation-associated protein	Wood V, Coggill P	anon	Chahwan C	Domain	This is the central coiled-coil region of cut12 also found in other fungi, barring S. cerevisiae. The full protein has two predicted coiled-coil regions, and one consensus phosphorylation site for p34cdc2 and two for MAP kinase. During fission yeast mitosis, the duplicated spindle pole bodies (SPBs) nucleate microtubule arrays that interdigitate to form the mitotic spindle. Cut12 is localised to the SPB throughout the cell cycle, predominantly around the inner face of the interphase SPB, adjacent to the nucleus [1]. Cut12 associates with Fin1 and is important in this context for the activity of Plo1 [2].	21.50	21.50	22.80	22.80	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-10.99	0.71	-4.52	12	71	2009-09-11 11:20:04	2008-08-29 14:19:16	3	3	70	0	60	71	1	150.90	34	21.61	CHANGED	-ups+PRo+LTpALhDSR......cp.....st.t.....stpct...css.sscss..........t.pshp..tc-sD.TINLs-PRSpSGKYWKuEF...DsY+s+optEl+KLIp...............Y+phAKsYA+cKDpEApcLucKLKEEE...tKVupMEcclTpLsSsMsscsspss.....+EpLhp-	..............................................t..p.p.Ro+LopuL.c.uRp.............t..p........sp.................shppp.ppstpscp.................................pspspc..ps-sDsTlsLs-P+SQSG.KYWKuEF.........-sY+scsctEhcKLlp...............Y+plAKSYA+cKDsEAhcLs...cK.LKcEp...tKVtpMEc+lsc.hAuphssptsp...ts.....p..............................	0	10	27	46
+11333	PF11501	Nsp1		Non structural protein Nsp1	Pollington J	anon	pdb_2gdt	Family	Nsp1 is the N-terminal cleavage product from the viral replicase that mediates RNA replication and processing [1]. The specific function of the protein is unknown however the structure has been determined. The protein has a novel alpha/beta fold formed by a 6 stranded beta barrel with an alpha helix covering one end of the barrel and another helix alongside the barrel [1]. Nsp1 could be involved in the degradation of mRNA.	25.00	25.00	41.00	38.30	19.90	18.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.49	0.71	-4.25	3	172	2009-01-15 18:05:59	2008-08-29 14:20:12	3	4	67	2	0	150	0	115.00	98	1.95	CHANGED	HVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTsHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNG	..................HVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNG	0	0	0	0
+11334	PF11502	BCL9		B-cell lymphoma 9 protein	Pollington J	anon	pdb_2gl7	Family	The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes [1].	25.00	25.00	28.60	38.20	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.95	0.72	-4.43	7	124	2009-01-15 18:05:59	2008-08-29 14:29:02	3	1	64	6	72	108	0	39.90	55	3.04	CHANGED	GLSpEQLEHRERSLQTLRDIQRMLFP-.-+shuhts.st.p	..GLSpEQLEHRERSLQTLRDIpRhLFP-.Ep-.shtt..................	0	9	15	39
+11335	PF11503	DUF3215		Protein of unknown function (DUF3215)	Pollington J	anon	pdb_2grg	Family	This family of proteins with unknown function appears to be restricted to Saccharomycetaceae.	25.00	25.00	26.30	46.00	22.00	19.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.32	0.72	-4.35	4	29	2009-01-15 18:05:59	2008-08-29 14:51:24	3	1	19	1	17	22	0	80.50	36	91.50	CHANGED	hslsEhlssslGolsFDENtNll-ooGlG....ppRlpDIscLSpscLDppGaulhpDssl.spla+css+TlsVYTs..............up	.........tEhlPcslGTLsFD-NtNll-ooGlG.....cs+lpDIhclSpscLsppGa.ulhpD...splllplaKc..ss+TlslYTs...pp..............	0	2	9	17
+11336	PF11504	Colicin_Ia		Colicin Ia	Pollington J	anon	pdb_2hdi	Family	Colicins are toxic molecules secreted to kill other bacteria in times of stress. Colicin Ia kills susceptible E.coli cells by binding to the colicin I receptor leading to the formation of a voltage-dependant ion channel. The protein can be divided into three domains, a translocation domain, a receptor binding domain and a channel forming domain [1].	25.00	25.00	25.90	53.30	24.00	16.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.35	0.72	-4.08	3	56	2009-01-15 18:05:59	2008-08-29 15:50:56	3	2	40	2	0	53	0	70.40	98	12.45	CHANGED	KNTPDGKTIVSPEKFPGRSSTNDSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLSHSGLDYKRNILNDRNP	.....KNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNP	0	0	0	0
+11337	PF11505	DUF3216		Protein of unknown function (DUF3216)	Pollington J	anon	pdb_2hjm	Family	This family of archaeal proteins with unknown function appears to be restricted ton Thermococcaceae.	25.00	25.00	72.60	72.20	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.17	0.72	-4.19	2	14	2009-01-15 18:05:59	2008-09-01 09:09:30	3	2	13	4	11	16	0	95.10	49	60.44	CHANGED	MDhsEKVKtLs.cLtE-pLtcAI-RFlTLscGIEKTRGEtFAKAuIYGFLEGILTTLKhKapsEcIppLLs.lKpARE.pEAhLRKspPPlh.ppsL	........lE-VKuLscELGE-sLlpsIDuFlsLNcGLEsK+GE-FlcVuILGFLEGILTTLKhKa.p--+lscLL-cV+ppRtEL-thFRKs+sPlh-.........	0	1	1	6
+11338	PF11506	DUF3217		Protein of unknown function (DUF3217)	Pollington J	anon	pdb_2hql	Family	This family of proteins with unknown function appears to be restricted to Mycoplasma. Some members in this family of proteins are annotated as MG376 however this cannot be confirmed.	23.60	23.60	23.80	108.70	21.90	23.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.19	0.72	-4.33	2	7	2009-01-15 18:05:59	2008-09-01 09:20:58	3	1	7	6	3	5	0	99.70	69	100.00	CHANGED	MLNpVFLEGEIESopWShKKTGFLVTIKQhRhFGER.FTDaaVhYANGQLAaELEtaTpKaKTISIEGILRTYLE++StIWKTTIElVKIhpPpsclhIDYpE.	MLNpVhLEG.I-S.pWShpKTGFhVTIpQhRhFGpphFTDYYVIYANsQLuhELEKashcachluIcG.LpTY.-+KSclWKTpI.h.KIh................	0	2	2	2
+11339	PF11507	Transcript_VP30		Ebola virus-specific transcription factor VP30	Pollington J	anon	pdb_2i8b	Family	VP30 is a nucleocapsid-associated Ebola virus-specific transcription factor [1]. It acts by stabilising nascent mRNA in Ebola virus replication. The C terminal domain of VP30 folds into a dimeric helical assembly. VP30 assembles into hexamers in solution by an N-terminal oligomerisation domain which activates the transcription function of the protein. The oligomerisation is mediated by hydrophobic amino acids at 94-112 [1].	20.00	20.00	22.50	22.30	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.62	0.71	-4.32	3	31	2009-01-15 18:05:59	2008-09-01 09:42:50	3	1	20	4	1	29	0	130.00	60	46.56	CHANGED	LTLclLlcIAEaWAsp-IsclDDoKLRALLTLoAVLlRKFSKSQLupLCEoHLRHENLGQDQA-SVLEVYQRLHSDKGGsFEAALWQQWDRQSLoMFISAFLaVALQIPCESSoVVlSGLcpLhPPQsNus	...LTLcsLs+IhpYhpRp-IsclD-opL...RAhLoLosshlRKh..s+S.lsshsEhHlpHENLsQDQssslhpsYptlH.DKGGpFEAALWQtWD+pSlohFlpAhLaVhpsIPCESShsV.uuhcphl.Ppspu.......	0	1	1	1
+11340	PF11508	DUF3218		Protein of unknown function (DUF3218)	Pollington J	anon	pdb_2igs	Family	This family of proteins with unknown function appears to be restricted to Pseudomonas.	25.00	25.00	30.30	134.00	21.50	17.40	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.31	0.70	-4.83	2	9	2009-01-15 18:05:59	2008-09-01 09:51:37	3	1	6	8	1	8	0	187.90	63	96.74	CHANGED	pINIYQNPGQSluslYKGhApQCsPG.sFPEsQhlEAWDIPLhLHPEFlPsGDlSKhDppYuTlLAtE.ApslhlthpMsp-Kt+sCs.ElhsLloShupNLspIKuRaGusYLshhKtSPNhYPTsVGhph.uuGu.sQ-SGl.VSYGssLtpLT.uphQAMsLPtslKtLls.GlGl+LstPpa.ssaNsItoGlRYTTuVslhLAYaAsl	..pINIYQNPGQSluslYKGhApQCsPG.sFPEAQhlEAWDIPLhLHPEFlPsGDlSKhDppYuTlLAtE.AphlhlthpMsp-Kt+sCs.ElhsLloShupNLspIKuRaGuuYLshhKtSPNhYPTsVGhph.uuGu.sQ-SGl.VSYGsNLtpLT.uphQAMsLPtslKtLls.GlGl+LstPpa.ssaNsItoGlRYTTuVslhLAYaAsl.......	0	1	1	1
+11342	PF11510	FA_FANCE		Fanconi Anaemia group E protein FANCE	Pollington J	anon	pdb_2ilr	Family	Fanconi Anaemia (FA) is a cancer predisposition disorder. In response to DNA damage, the FA core complex monoubiquitinates the downatream FANCD2 protein. The protein FANCE has an important role in DNA repair as it is the FANCD2-binding protein in the FA core complex so it represents the link between the FA core complex and FANCD2 [1]. The sequence shown is the C terminal domain of the protein which consists predominantly of helices and does not contain any beta-strand. The fold of the polypeptide is a continuous right-handed solenoidal pattern from the N terminal to the C terminal end [1].	22.20	22.20	24.00	23.50	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.86	0.70	-5.25	2	95	2009-09-11 15:02:58	2008-09-01 11:06:15	3	2	65	1	56	91	0	198.80	32	49.62	CHANGED	u....LupShpLPcthpstLPhlppLLcs.pE....h-DussstLplLHECsPsph-lLCu.LpLsplS-.sL.phCohLLtLuPDLShSsAosLhppLhLt+ILSLspsASRhLsTAlTShCu+YshPsCpALl-PlLQtsthGsAQs-LLCpLV.h-sLEPctplLhhtphLthsWcEtsh.VlpuLL-pplEho.EcFslhhE+LCppu.thopSMtaAKhhLoVhTKYQuNls.sp+hsLu.sLp.NpTFL+KSLpAALK+lu	............................................................................................................................ht.lst.Lph.phs-.slhplCs......lhs..L.o...sshSh....ss.....u.ss.lh.psLhLs+lluL..sp.sASRh..LhsAlsshC.t..+ashssspullhP.l.L.p....ts.t.......h.Gss.Qs-LLspll...t-..sLc...............sch.....p...h..hh...l....t...p..h.....L................p........h..s...........W..pEth.h.VlpslLppp.....hs....p.ht.hhp.l.....t.....tt..u.t....hspShtauphhhshhsphttplt..p.....l..hlt.stThhp+sh.shl....t..........................	0	15	22	37
+11343	PF11511	RhodobacterPufX		Intrinsic membrane protein PufX	Pollington J	anon	pdb_2ita	Family	PufX organises RC-LH1, the photosynthesis reaction centre-light harvesting complex 1 core complex of Rhodobacter sphaeroides [1]. It also facilitates the exchange of quinol for quinone between the reaction centre and cytochrome bc(1) complexes. In organic solvent, PufX contains two hydrophobic helices which are flanked by unstructured regions and connected by a helical bend [1].	25.00	25.00	30.80	30.70	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.92	0.72	-4.58	5	18	2009-01-15 18:05:59	2008-09-01 12:54:39	3	1	18	3	3	14	33	66.20	38	84.78	CHANGED	MscaNDhLss..NsKoRLRADlshLMLKGAGYAAVFVlulWFlIuuhtlIG+hLPEQSRpTPDPsppuA	..........ho..sDaLss..ssKspLRlWlshQMhKGAGaAussFhuslhllsshtslGphLP.ppppAPuPs.h.....	0	1	2	2
+11344	PF11512	Atu4866		Agrobacterium tumefaciens protein Atu4866	Pollington J	anon	pdb_2jmb	Family	Atu4866 is a protein with unknown function from Agrobacterium tumefaciens however the structure has been determined. Atu4866 adopts a streptavidin-like fold and has a beta-barrel/sandwich which is formed by eight antiparallel beta-strands [1]. Atu4866 has a potential ligand-binding site where is has a stretch of conserved residues on the surface [1].	25.00	25.00	25.70	25.30	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.57	0.72	-4.24	14	114	2009-01-15 18:05:59	2008-09-01 13:19:10	3	2	95	1	47	122	1	77.40	61	65.27	CHANGED	tpp+sYlGMWVTuDGaIRHELLPsGRYDEARGsRcSAYpGRYclTGsHI-YhDDTGFTADG-Fh.ssVLaHuGMVLaRc	..................tHPYVGMWVTsDGpIRpELLPsGRYDEARGsRcSAYpGRYpVsGsHI-YhDDTGFTADG-Fh.-slLaHuGMVhYRp.....	0	11	26	33
+11345	PF11513	TA0956		Thermoplasma acidophilum protein TA0956	Pollington J	anon	pdb_2jmk	Family	TA0956 is a protein from Thermoplasma acidophilum which currently has no known function however the structure has been determined. The protein has a two-layered alpha/beta-sandwich topology and is a putative Elongation factor 1-alpha binding motif [1].	25.00	25.00	181.50	181.30	22.20	18.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.27	0.72	-4.01	3	3	2009-01-15 18:05:59	2008-09-01 13:27:54	3	1	3	2	3	7	4	110.30	51	97.07	CHANGED	MsLCAMYNISMcspHPTTICVVMDKFLDSFuELlDVl--sDpDE.LMDFISRYARTDEIMPEDKTVGFVVINuDKKlMSVSFSDIDENM...KcsI+EIlKKYKDpGYKVEsDh	MsLCAMYNISMcspHPTTICVVMDKFLDSFuELlDVl--sDpDE.LMDFISRYARTDEIMPEDKTVGFVVINuDKKlMSVSFSDIDENM...KcsI+EIlKKYKDpGYKVEsDh	0	1	2	2
+11346	PF11514	DUF3219		Protein of unknown function (DUF3219)	Pollington J	anon	pdb_2jn9	Family	This family of proteins with unknown function appears to be restricted to Bacillaceae. Some members in this family of proteins are annotated as YkvR however this cannot be confirmed.	25.00	25.00	82.10	82.00	16.80	16.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.37	0.72	-4.10	2	29	2009-01-15 18:05:59	2008-09-01 13:38:47	3	1	29	1	7	31	0	92.60	55	97.71	CHANGED	KplhLNsspl-hhsYpEEo...cscptI..uFshpVopppYHDIssLLY-hhFsVpVPEcsLtFRG.hspY.TSLTNLYE.sAVuEFalElpEhDtptD	..................lhLNsVplchhsYpEEs.......cstRpI..uFsLcVTSETYHDIAVLLYEKTFcVcVPE+sLsFRGpITNYSTSlTNLYccspVu-FalElTEl.........	1	1	5	5
+11347	PF11515	Cul7		Mouse development and cellular proliferation protein Cullin-7	Pollington J	anon	pdb_2jng	Family	The Cullin Ring Ligase family member, Cul7, is required for normal mouse development and cellular proliferation. Cul7 has a CPH domain which is a p53 interaction domain. The CPH domain interaction surface of P53 is present in the tetramerisation domain [1].	25.00	25.00	25.10	28.80	20.10	18.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.81	0.72	-4.08	8	206	2009-01-15 18:05:59	2008-09-01 13:50:29	3	43	71	2	103	188	0	76.00	52	2.97	CHANGED	RcDFpSsDsYAhYVR-slpsGMhVRCCc-YEElppGDhGpVh+l-s-GlpDLNVQVsWps+GpTYWV+ahHVEllGsss	.........Ru-FtSsssYAhYVR-slpsGMpVRhhc-YE.Els.tGD.Gc.h+.sssGl.s..VQV.WpspGpTYWV+ahhlEllGh.s...............	0	19	23	51
+11348	PF11516	DUF3220		Protein of unknown function (DUF3120)	Pollington J	anon	pdb_2jpf	Family	This family of proteins with unknown function appears to be restricted to Bordetella.	25.00	25.00	240.50	240.50	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.34	0.72	-4.06	2	4	2009-01-15 18:05:59	2008-09-01 14:06:47	3	1	4	1	1	4	0	106.00	98	16.14	CHANGED	KQQLpEpAPSHANLDVKWLDGLRAGSMALQGDVKVWMQNLEDLHTRRPDEFsARLQQSTDALYSHLEAQWAKQHGTPPTASDVsGMPQWQEYTAMLRERFAGLDTI	KQQLHEQAPSHANLDVKWLDGLRAGSMALQGDVKVWMQNLEDLHTRRPDEFAARLQQSTDALYSHLEAQWAKQHGTPPTASDVAGMPQWQEYTAMLRERFAGLDTI	0	1	1	1
+11349	PF11517	Nab2		Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)	Pollington J	anon	pdb_2jps	Family	Nab2 is a yeast heterogeneous nuclear ribonucleoprotein that modulates poly(A) tail length and mRNA. This is the N terminal domain of the protein which mediates interactions with the C-terminal globular domain, Myosin-like protein 1 and the mRNA export factor, Gfd1 [1].The N-terminal domain of Nab2 shows a structure of a helical fold. The N terminal domain of Nab2 is thought to mediate protein protein interactions that facilitate the nuclear export of mRNA [1]. An essential hydrophobic Phe73 patch on the N terminal domain is thought to be a important component of the interface between Nab2 and Mlp1 [1].	25.00	25.00	32.40	30.40	23.10	22.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.44	0.72	-3.96	4	26	2009-01-15 18:05:59	2008-09-01 15:41:18	3	4	26	4	17	26	0	101.20	57	19.60	CHANGED	MS..p-pIspsLKslVAEKLpsl.NFsEDVpYVAEYIVLLhSNGGoh-SlVQELsoLFDoVSppsLssVVQTuFhAL-hLppG-slpslhuKlp...hhuupssupusos	.......MS..pEQhoENLKVIVAEKLssl.NFNEDlcYVAEYIVLLIsNGGTlESVVpELuoLF.DoVSp-sLssVVQTAFFALEALQQGEosEsIVuKIR...hM.supuhupt...s..............................................	0	2	8	14
+11350	PF11518	DUF3221		Protein of unknown function (DUF3221)	Pollington J	anon	pdb_2jqo	Family	This family of proteins with unknown function appears to be restricted to Bacillus. Some members in this family of proteins are annotated as YobA however this cannot be confirmed. YobA is a protein with unknown function.	20.80	20.80	21.00	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.45	0.72	-4.39	9	132	2009-01-15 18:05:59	2008-09-01 15:47:07	3	2	109	1	15	95	1	105.10	40	84.54	CHANGED	lhL.lhhhlhotsssptsE...spphohEGYlIl+.NspshhlsDcshpsK.-hpphhEpplhpcasusIVL....thpshsshcpLpsGpKIKVWasplhES.Pu+hhlpKaEll	..............................hh.lhLhlhu..s.sssppsE..........sccsshEGYlIl+.N-.s...s..a...hlsDcshpsK.ELppY.hEp...php..p-aPucIlL.....hc-c..-.u..acpLKsGDKIKVW..S.p...h.hESYPu+hhVpKaEl..........	0	2	9	11
+11351	PF11519	DUF3222		Protein of unknown function (DUF3222)	Pollington J	anon	pdb_2js3	Family	This family of proteins with unknown function appears to be restricted to Rhodopseudomonas.	25.00	25.00	141.40	141.30	19.50	17.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.56	0.72	-4.02	3	7	2009-01-15 18:05:59	2008-09-01 15:50:14	3	1	7	2	6	7	0	74.70	74	100.00	CHANGED	MT-FAAEDVRKIAAALVKTAIETVSEEDGGARNQCKLCNASVPWLQTGDEIpHpPDCAVAIAQRIL.AKs+LHSV	MTDhAAEDVRKIAsALlKTAIEIVSEEDGGAHNQCKLCsASVPWLQTGDEIpHAPDCPVVIApplLuu+P+LHuV	0	0	1	2
+11352	PF11520	Cren7		Chromatin protein Cren7	Pollinton J	anon	pdb_2jtm	Family	Cren7 is a chromatin protein found in Crenarchaeota and has a higher affinity for double-stranded DNA than for single-stranded DNA. The protein contains negative DNA supercoils and is associated with genomic DNA in vivo.Cren7 interacts with duplex DNA through a beta-sheet and a long flexible loop. The function has not been completely determined but it is thought that the protein may have a role similar to that of archaeal proteins in Euryarchaea [1].	39.00	39.00	60.50	60.20	38.80	37.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-8.87	0.72	-4.33	7	51	2009-01-15 18:05:59	2008-09-01 16:18:15	3	1	43	5	34	42	0	58.70	53	95.26	CHANGED	M....sscc..shcs+ss.sGKEhcLhPhKsW.LsP+GRKGVhlGLF+sPp.GKYFRt+Vs-t.P	............tcc..sl+l+ss.sGKEh-LhPpKVWsLsPKGRKGVKIGLFKsP-oGKaFR++lP-sYP..	0	10	19	24
+11353	PF11521	TFIIE-A_C-term		C-terminal general transcription factor TFIIE alpha	Pollington J	anon	pdb_2jtx	Family	TFIIE is compiled of two subunits, alpha and beta. This family of proteins are the C terminal domain of the alpha subunit of the protein which is the largest subunit and contains several functional domains which are important for basal transcription and cell growth. The C terminal end of the protein binds directly to the amino-terminal PH domain of p62/Tfb1 (of IIH) which is involved in the recruitment of the general transcription factor IIH to the transcription preinitiation complex. P53 competes for the same binding site as TFIIE alpha which shows their structural similarity. Like p53, TFIIE alpha 336-439 can activate transcription in vivo [1].	21.10	21.10	21.20	21.40	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.99	0.72	-4.04	8	111	2009-01-15 18:05:59	2008-09-01 16:44:00	3	5	89	3	80	101	0	84.30	38	19.99	CHANGED	SsSDTSESDcD.ssscsPstt..........spch--p--DD-.E-ssD-PsVhVuGRPasYcEVSQpPcLVuQMTPQEKEsYIphGQchFpclY-	......................................spS-oS-s-c-.s....sc.ss.ss...............phc.tc-p-----hE-s...sD..-P..sVhVAG+Pashs-V.o...P-LV.A.QMTPpEKEsYIp.hsQchFpcha-......	0	28	35	58
+11354	PF11522	Pik1		Yeast phosphatidylinositol-4-OH kinase Pik1	Pollington J	anon	pdb_2ju0	Family	Pik1 is a regulator of membrane traffic and participates in the mating-pheromone signal-transduction cascade. The protein is localised to the nucleus and cytoplasm in the Golgi. Pik1 is thought to have an actin-independent role in membrane transport [1].	21.40	21.40	21.40	24.60	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.62	0.72	-4.22	20	95	2009-09-10 18:11:33	2008-09-01 16:58:07	3	4	83	1	64	94	0	50.50	41	5.27	CHANGED	SauFQlsRRllN+lQpllFsss...................pps+ps+h+ENltPALVLsuhVhoSlA	......ShuFQssRRlhN+lQpIlFsss....................sts+pp+h+ENlhPuhVLuShlhuSlA.................	0	16	39	60
+11355	PF11523	DUF3223		Protein of unknown function (DUF3223)	Pollington J	anon	pdb_2k0m	Family	This family of proteins has no known function.	21.00	21.00	22.60	21.90	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.61	0.72	-3.69	30	196	2009-01-15 18:05:59	2008-09-02 09:24:51	3	16	68	1	129	193	9	74.50	34	13.45	CHANGED	h+thL+..+YssGcpls..sp-tpsllptlLpaHP.....cs-pKlGsG.l.cthpVtpasthp.t....S+CFalVRs..DGop.....-DFSYpKCl	...........h.ptlL+..catssppls..tp-pphllcplLpaHP................csccKIGsG....l.ctlpVshHPtap..t.....SRCFallRp..DGot......pDFSYpKCl..............	0	38	90	114
+11356	PF11524	SeleniumBinding		Selenium binding protein	Pollington J	anon	pdb_2jz7	Family	Selenium is an important nutrient that needs to be regulated since lack of the nutrient leads to cell abnormalities and high concentrations are toxic.\	SeBP regulates the level of free selenium in the cell by sequestering the nutrient during transport. SeBP acts as a pentamer and delivers the selenium to the selenophosphate synthetase enzyme [1]. Each subunit is composed of an alpha helix on top of a four stranded twisted ss sheet, stabilised by hydrogen bonds [1].	27.90	27.90	28.00	58.30	27.10	27.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.74	0.72	-3.85	3	13	2012-10-01 20:55:33	2008-09-02 09:31:10	3	1	13	5	6	11	0	83.00	52	98.99	CHANGED	MlFEDKFIITTADEIPGLpLYYlGIVSslSD..NVDcIVEsL+EKVKAKGGMGLIAFRITs...ADG.KaLGYGTAVKADEGQFTMA	...MlFEscFIITTAc-IPGlpLYhhGIVSssSD..NVDpIlcsLcEpVpAKsGhGLluFRITs....uDG..KhlGYGTAVKADEuQFsMs.	0	0	1	4
+11357	PF11525	CopK		Copper resistance protein K	Pollington J	anon	pdb_2k0q	Family	CopK is a periplasmic dimeric protein which is strongly up-regulated in the presence of copper, leading to a high periplasmic accumulation [1]. CopK has two different binding sites for Cu(I), each with a different affinity for the metal. Binding of the first Cu(I) ion induces a conformational change of CopK which involves dissociation of the dimeric apo-protein. Binding of a second Cu(I) further increases the plasticity of the protein. CopK has features that are common with functionally related proteins such as a structure consisting of an all-beta fold and a methionine-rich Cu(I) binding site [1].	19.90	19.90	19.90	69.40	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.62	0.72	-4.33	5	22	2009-09-11 07:29:11	2008-09-02 09:51:31	3	1	19	9	13	18	18	71.80	56	78.22	CHANGED	VDcuslcKSl-LKDGSTVHlFKDGKMuMEDKhG+uhpMKcGpVMET+DGQKIhM+GDEVhRLDshL+KcH.p+G	..A..spuscchl.LtDGuTlYIFKDGKMA.Es+aGRAVhhphGsshpTKDGppIshpusEVARLsSLLp+cH....Gs..	0	1	10	13
+11358	PF11526	CFIA_Pcf11		Subunit of cleavage factor IA Pcf11	Pollington J	anon	pdb_2npi	Family	Pcf11 is a subunit of an essential polyadenylation factor in Saccharomyces cerevisiae, CFIA. Pcf11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [1].	21.10	21.10	21.30	21.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.13	0.72	-3.84	10	54	2009-01-15 18:05:59	2008-09-02 10:47:12	3	4	53	2	37	53	1	83.30	29	14.42	CHANGED	s...............ps.spNIQSRNWYLDD.-WVpFKDD-llphoossss.t....................pphppshss.p.ts..hs.pph+spYVVVPsssosMs.+	...tsp....ssstKNlQSRsWYLcDpcWlp...F..+-..--Isuss.pssst.p.ts...................................pptspstss..........................hptpYVlVPpstpsMs.p.........................	0	6	20	34
+11359	PF11527	ARL2_Bind_BART		The ARF-like 2 binding protein BART	Pollington J	anon	pdb_2k0s	Family	BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterised [1]. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [2].	20.90	20.90	20.90	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.62	0.71	-4.32	32	294	2009-01-15 18:05:59	2008-09-02 10:47:57	3	6	116	4	198	272	4	113.80	29	40.86	CHANGED	hs..cpchlhpplhpaltSs..WpsslpsFh-ppC..hhF--p...-EsplphpplapcYppll-phlpphlp........phuls.cpatpsl........................p.tpppphtpslhp.lhshpDFphF+chMlppNh-l-hpu	....................................tt....c.chlhttl.shlhsst.aph.hpsFh-pps..............hF-.cp...............-E....sKLpYopIapc.YppLlEchl-phLp........t.Ghs..ppFtpsh.....................................ttcschst...s.lhp..llshsDFhhFKpMMlphphEhph..........................................	0	84	104	150
+11360	PF11528	DUF3224		Protein of unknown function (DUF3224)	Pollington J	anon	pdb_2ooj	Family	This bacterial family of proteins has no known function.	25.00	25.00	27.50	29.70	21.10	18.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.47	0.71	-4.65	11	250	2009-01-15 18:05:59	2008-09-02 12:59:52	3	1	238	4	66	200	15	131.80	34	97.93	CHANGED	Mphp..hhGsFplohWsE..oshs-ssss..hspsplspsa.pGDlcGpSplcaLhsY......pu.tuuAsaVGhEphpGslsG+pGoFVLQHpGphspGssssshs.lV.sSGTupLtsLsGshshshss.ssp.u.cFphshtsu	...............................hp.......puoFoVspWsE..............ps.l..ss...t...s.......c..s.h.s...........l...........spAslshph.sGsLpG.p.u.ps.EYLhsY.......su..hpusAphl..Ga.+....FcG.shtG.+pGoFs.hpcp..Gsa.s.pG.t.h...c.s..s..hp..ll..puTG-LtGL...sGshshphsp..spc..hhpath.....h............	0	28	48	56
+11361	PF11529	AvrL567-A		Melampsora lini avirulence protein AvrL567-A	Pollington J	anon	pdb_2opc	Family	AvrL567-A is a protein from the fungal pathogen flax which induces plant disease resistance in flax plants [1]. The protein has a novel fold [1].	19.30	19.30	20.30	69.80	18.00	19.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.57	0.71	-4.16	3	13	2009-01-15 18:05:59	2008-09-02 13:09:21	3	1	2	2	1	14	0	126.90	81	84.57	CHANGED	MEDVPAELTGVSEGYTRFYRSPTASVTLSGLVcVKWDNEQMTMPLFKWIGGEQAEELHFCVHIAHSSGRRLNpARTLGTVNSNMDQHWVEAYRSSGVTRCTIQDCHLFANDIPNFPDYIKIKLVPKT	.........MEcVPAELTGVSEGYTRFYRSPTASVsLSGLVcVKWDNEQMTMPLFKWIGGEQAEELHFsVHIAHSSG.+LNpARTLGTVNSNMDQHWspAYRsSGsTRpTIQDpHLFANDI...PNFPDYIKIKLVPKT.....	1	1	1	1
+11362	PF11530	Pilin_PilX		Minor type IV pilin, PilX	Pollington J	anon	pdb_2opd	Family	PilX is a protein from Neissaria meningitidis which is crucial for the formation of bacterial aggregates and adhesion to human cells [1]. The structure of PilX is similar to all pilins as it has the common alpha/beta roll fold. PilX subunits have surface-exposed motifs which are thought to stabilise bacterial aggregates against pilus retraction. It also illustrates how a minor pilus component can modulate the virulence properties of pili which have a simple composition and structure [1].	25.00	25.00	35.30	34.70	23.90	23.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.47	2	59	2009-01-15 18:05:59	2008-09-02 13:32:49	3	3	58	6	2	56	0	126.50	71	79.05	CHANGED	SYIEKGYQSQLYTEMVGINNl.KQFILKNP.DDNpTlKSKLcIFVSGYKMNPKIAcKYsVSV+FVstEKPRAYpLVGVPpsGTGYTLSVWMNSVGDGYKCRDAsSApAa.-TLSuDsGCEAFSNRKK	.SYIEKGYQSQLYTEMVGINNlhKQFILKNPh.DD.NQsIKoKLEhFVSGYKMN..PKIAcKYsVSV+...F..V..s..tE........KsRAYpLVGVPKsGTGYTLSVWMNSVGDGYKCRDAASAcAapETLSuDsGCEAFSNRKK..........	0	1	1	1
+11363	PF11531	CARM1		Coactivator-associated arginine methyltransferase 1 N terminal	Pollington J	anon	pdb_2oqb	Family	CARM1 is an arginine methyltransferase which methylates a variety of different proteins and plays a role in gene expression. This is the N terminal domain of the protein which has a PH domain, normally present to regulate protein-protein interactions.A molecular switch is also present on the N terminal domain [1].	20.40	20.40	20.50	21.20	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.60	0.71	-4.35	3	78	2009-01-15 18:05:59	2008-09-02 14:17:24	3	4	42	10	39	69	0	91.60	59	17.53	CHANGED	M...AAVSVFPGVRLLSIGDANGEIQRHAEQQsLRLEVRAG.DuAsIALaNsE-VCVFKCTVoRETECSRVGKQSFIITLGCNSVLlQFATPADFCSFYNILKoCRGpcuERSVFSE	................................................................................................h.stE-V....CVFKCSVSRETECSRVGKQSFIITL.GCNSVLlQFATPsDFsSFY.N.ILKsCRGHshE+SVFSE....................	0	8	12	22
+11364	PF11532	HnRNP_M		Heterogeneous nuclear ribonucleoprotein M	Pollington J	anon	pdb_2ot8	Family	HnRNP M is a splicing regulatory factor that binds to the auxiliary RNA cis-element ISE/ISS-2 which promotes splicing of exon IIIb and silencing of exon IIIC in the fibroblast growth factor receptor 2 (FGFR2) [1]. By binding to ISE/ISS-3, HnRNP M plays a role in the regulation of alternative splicing in FGFR2 as it induces exon skipping and promotes exon inclusion [1].	20.70	20.70	22.70	23.10	20.30	18.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.44	0.72	-3.85	3	73	2009-01-15 18:05:59	2008-09-02 14:30:45	3	4	35	2	30	54	0	29.50	80	4.60	CHANGED	-psoQNEKRKEKshKR.GGNRFEPYSNPsKR	........ERPsQNE..KRKEKNIKR..GGNRFEPYuNPTKR.	0	1	3	11
+11365	PF11533	DUF3225		Protein of unknown function (DUF3225)	Pollington J	anon	pdb_2owp	Family	This bacterial family of proteins has no known function.	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.69	0.71	-4.45	24	251	2012-10-03 02:27:24	2008-09-02 14:42:48	3	5	240	6	86	307	27	123.10	51	80.95	CHANGED	hpINtPcVlAEVsAAFtcYEpALssNDVssLDtLFWssPcTlRYGsuENLYGh-tI+AFRtsRsusuLsRplh+TslTTFGcDhAssssEFpR..cGus.RlGRQpQTWlRh.s-.GW+lVAAHVSlh.ps	..........................................................pIshPtllAEVoAAFhcYEpAL....luNDlssLDtLFWpss+.TV...R.a.G..........s.u..E.N.LYG.h.-sI.+.A.F...Rt.u.R...sus.......G...h...s..R...p.L.......t........c....T..sITT......FG..c.....D.h.....A....s...s..o..T..E..FpR........cG..os....+l.G..R..Q........Q.....T..WlR....h......ss....G........W+lVAAHVSLh..s......................................................	0	14	41	60
+11366	PF11534	HTHP		Hexameric tyrosine-coordinated heme protein (HTHP)	Pollington J	anon	pdb_2oyy	Family	HTHP is from the marine bacterium Silicibacter pomeroyi and has peroxidase and catalase activity. HTHP consists of six monomers which each binds a solvent accessible heme group and is stabilised by the interaction of three neighbouring monomers [1]. The heme iron is penta-coordinated with a tyrosine residue as proximal ligand [1].	25.00	25.00	25.70	32.10	24.00	23.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.56	0.72	-3.91	9	36	2009-01-15 18:05:59	2008-09-02 15:55:30	3	2	34	8	21	45	5	69.40	51	80.69	CHANGED	hs-sWLPoLhTsTPpEGapLAVKhARluVKhTQPDs-lRppLRssYucDAsuLIAsSpVlAsaFATlAAANsYW+	..........hsoLhTsTPpEGhpLAlKluRhulKhTQPDs-lRcpLRs.YupDustLIAsSQVVAhcFtTlAAANNYW+......	0	6	12	18
+11367	PF11535	Calci_bind_CcbP		Calcium binding	Pollington J	anon	pdb_2p0p	Family	CcbP is a Ca(2+) binding protein which, in Anabaena, is thought to bind Ca(2+) by protein surface charge. When bound to Ca(2+), the protein becomes more compact and the level of free calcium decreases. The free Ca(2+) concentration which is regulated by CcbP is critical for the differentiation process [1]. Calcium signalling is widespread in bacterial species, and prokaryotic cells like eukaryotes are equipped with all the elements to maintain Ca2+ homeostasis [2].	21.50	21.50	21.90	21.50	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.32	0.72	-3.79	17	53	2009-12-03 17:50:01	2008-09-02 16:15:08	3	2	45	3	25	55	5	97.80	26	66.48	CHANGED	cRIthEIlVDAY........stcEpthGWYpaL--sLphPFpAhhht...............tpVpVluhu.p-ps.tphhVplph....spcphslsLppLtshcsDspopp........AltDW+YWls	..................................................th..chhVDsY........stpEphhuWhtaLp-plphPFpuhhht.......................s....tcpVpVluhssppsp.tthhVplch....sccphslsLs-Lcsh-ssspspp.............slsDapaWh..................	0	7	19	22
+11368	PF11536	DUF3226		Protein of unknown function (DUF3226)	Pollington J	anon	pdb_2p62	Family	This archaeal family of proteins has no known function.	20.80	20.80	20.80	21.00	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.51	0.70	-4.92	4	17	2009-01-15 18:05:59	2008-09-02 16:23:43	3	2	15	2	12	23	0	205.50	28	76.19	CHANGED	h+lLllEG+TDsuFFhsllKKLYGF+Eu+..scsl.hhE...Kht-hs+slsLcKDshtLlVhHupGKsplh+sLpshLcAlch.hh.slchlGlARDVDp-c-lhsWspShl+puuFEs+hsssalllp..slKIhPhGIGpl...sFst..l-hKK.ELEhlhshLAKt-ulLEKh+sSlpuLppDhGRKLpPKDlMHlLuIApsasGDshSGLYcpFItc.I+cN+chV.chLs.hslL.hLshhh	....plLhlEG+TDspFFpslhKKLatF..+Eucthstpl...hh-.............phhEhsph.hL..c+..-sshlslhsupGpsslh+sLtshlcu.hcl.hthplptlGlshDlDcsc-s.shtp.hhp.ttap.t.tshhhhl...th.lhshhhG.h...shp.t..l..-.+K.plE.hhhhLhctpuhLp+hc.ulp.Lp.shtcKLpPK-lhalh..A.tahGs.hpGhYc.al.h.hh.php.l.p.hs..t.........th........................................................................................	0	2	2	8
+11369	PF11537	DUF3227		Protein of unknown function (DUF3227)	Pollington J	anon	pdb_2p9x	Family	This archaeal family of proteins has no known function.	21.20	21.20	23.90	23.80	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.19	0.72	-3.91	2	9	2009-09-10 21:06:52	2008-09-02 17:19:47	3	1	9	4	8	11	0	96.40	31	95.49	CHANGED	hp.s+sllstThhphLpphuPth.ssLEAaLpAphNtslElAhEDPtKFhcAVpcLFGEauAphh.hsll.cLp.h.sKp....shEpllt.lKKhh....G	.............p.sc-llspslpthl+cluPsLcslLEh+L+uphsK.Gh.ElAhEDPpcF+-AVS+LFGEa.SA+LlthhllscL+.hlt.p.phpsLEpllp.l+..............................	1	2	4	6
+11370	PF11539	DUF3228		Protein of unknown function (DUF3228)	Pollington J	anon	pdb_2pd0	Family	This family of proteins has no known function.	25.00	25.00	207.50	207.30	21.00	19.10	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.37	0.71	-5.21	11	64	2009-01-15 18:05:59	2008-09-02 17:22:04	3	2	62	6	40	71	54	192.10	49	89.79	CHANGED	hplsL-sFsh+Qacpp.hpsshIs.hspEpFlp+lNchhc.sshcllDGYAPFCKHlFlcNFT-sp......stslcITscNc+LL....+ouY.ARs-pELPVLsRWFshpsVp.ppl..ApYLDlILYS+EQlpKEssthtp...........ssDauIlSIKsQspsaElPMtPITMhRNAL.l-EGGSGVsLDREcYhcSVcaWpcaAslhs	.........plsLssFAhpph.sps....hpsstIp.hs.-pFlp+lN-t.....s...shcll-GYAPFCKhhhlcN.aT.us+......shslsITscNcHLL....RSGYpARsspELPVLsRWF..cs..Vc.ssl...............ApYLclILYSREQlsKEsssh...............-ucWGIlulphpsEs.ElPMsPITMhRNALGlEEGGSGVPLDR-tYpcSVtaWcppAshhs.	0	21	28	36
+11371	PF11538	Snurportin1		Snurportin1	Pollington J	anon	pdb_2p8q	Family	Snurportin1 is a novel nuclear import receptor which contains an N-terminal importin beta binding domain which is essential for its function of a snRNP-specific nuclear import receptor [1]. Snurportin1 interacts with m3G-cap where it enhances the m3G-cap dependent nuclear import of U snRNPs in Xenopus laevis oocytes and digitonin-permeabilized HeLa cells [1].	20.80	20.80	20.80	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-8.09	0.72	-4.18	6	77	2009-01-15 18:05:59	2008-09-02 17:22:04	3	3	55	15	45	67	0	40.00	63	12.48	CHANGED	HPRLSpYKsK.tsuh-QucRRR+hLElQKp+R..LDahs+uR+	....HPRLS.Q....YKuK..aSuL.EQSERRR+LLELQKsKR.....LDYVNHARR.........	1	12	17	28
+11372	PF11540	Dynein_IC2		Cytoplasmic dynein 1 intermediate chain 2	Pollington J	anon	pdb_2pg1	Family	Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules [1]. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex [1]. 	25.00	25.00	26.60	26.90	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.25	0.72	-4.58	10	218	2009-01-15 18:05:59	2008-09-03 09:13:31	3	4	80	7	86	257	0	32.80	60	5.67	CHANGED	u++sh+LuhScVsplDFsPKEsVoYSKETQTss	.....tRtshKLGhuKlTQVDFPPRElVoYoKETQTPs..	0	24	30	53
+11374	PF11542	Mdv1		Mitochondrial division protein 1	Pollington J	anon	pdb_2pqn	Family	Mdv1 is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation [1]. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependant devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly [2].	25.00	25.00	28.00	27.00	23.40	22.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.48	0.72	-4.04	2	12	2009-01-15 18:05:59	2008-09-03 11:17:30	3	2	12	3	4	11	0	49.60	90	7.29	CHANGED	DADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY	..DADGKLLTEGGEDENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY...	0	1	1	2
+11375	PF11543	UN_NPL4		Nuclear pore localisation protein NPL4	Pollington J	anon	pdb_2pjh	Family	Npl4 is part of the heterodimer UN along with Ufd1 which is involved in the recruitment of p97, an AAA ATPase, for tasks involving the ubiquitin pathway. Npl4 has a ubiquitin-like domain which has within its structure a beta-grasp fold with a helical insert [1].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.37	0.72	-3.70	9	177	2012-10-03 10:59:06	2008-09-03 11:20:48	3	14	147	2	124	200	2	78.60	30	14.25	CHANGED	MstphllRVQSs-GhKRlphopppThsphhcKVtcphuFspp.tFulah-RNposEl.uSpspplp.ltl+HGDhL.aLh.s	.................hllRlpSs-GhcRl.p.s..s.t..pp.T....huplh....ccltcp.h..s.hsss...u...h.sl.a..hs........c........s...........t......s...........sc.......l.t........u.......s...s.......s.p..o....L....s........LtlpHGDhl.aLh...............................	0	46	72	100
+11376	PF11544	Spc42p		Spindle pole body component Spc42p	Pollington J	anon	pdb_2q6q	Family	Spc42p is a 42-kD component of the S.cerevisiae spindle body that localises to the electron dense central region of the SPB [1].Spc42p is a phosphoprotein which forms a polymeric layer at the periphery of the SPB central plaque. This functions during SPB duplication and also facilitates the attachment of the SPB to the nuclear membrane [1].	21.10	21.10	21.30	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.69	0.72	-4.05	5	30	2009-09-11 12:37:10	2008-09-03 12:45:58	3	3	26	2	21	27	0	72.90	38	16.96	CHANGED	NcLIKQNKELpsKLcEKQ-EI-RLNlLlGSLRAKLIKYTELNKKLpc-tQstQpp.sslscsto-stsDulhhsc+u	.......NchlpQNK-LphKLc-KQsEI.cLpplspoLRuKL.KYs-lsKK..LEcpshshphp.sshppphs-..ss........................................	0	3	9	18
+11377	PF11545	HemeBinding_Shp		Cell surface heme-binding protein Shp	Pollington J	anon	pdb_2q7a	Family	Shp is part of a complex which functions in heme uptake in Streptococcus pyogenes. During which, Shp transfers its heme to HtsA which is a component of an ABC transporter. The heme binding region of Shp contains an immunoglobulin-like beta-sandwich fold and has a unique heme-iron coordination with the axial ligands being two methionine residues from the same Shp molecule [1]. Surrounding the heme pocket, there is a negative surface which may serve as a docking interface for heme transfer [1].	25.40	25.40	26.10	31.60	23.20	25.30	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.96	0.71	-4.40	3	63	2009-01-15 18:05:59	2008-09-03 13:00:48	3	2	61	2	4	59	2	148.50	42	44.61	CHANGED	ADKGplYoClIpRsYRHPVSGQIEDSGGEHuF-IGQGMVEGTVYSsGMLEVTDAG-lYLTFRMSLADYSGNYQFWVQPGGTGuFQAsAYulTpsGTDTNGTTtDIAIuLPoVNoVVRGSMYVEPMGREVVFYLSPSELpEGYSGDMlAohVT	......................tuplYsshlppsYcHPloGpIED...uG...Gptuh....sIGQGMVEusVausuhLEsoDuG+lhLThRhuLADa...sushp...FhlQ.s.sGsG...uFpuVshslTppGoDs...NGTT........tD.ltIplPohNslIRuSMaVEPMGR-VlFYl..ssuph...pt.ossh.s.h........................	0	1	2	3
+11378	PF11546	CompInhib_SCIN		Staphylococcal complement inhibitor SCIN 	Pollington J	anon	pdb_2qff	Family	SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface [1]. An 18 residue stretch 31-48 is crucial for SCIN activity [1].	21.30	21.30	22.10	21.80	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.37	0.71	-4.23	4	473	2009-01-15 18:05:59	2008-09-03 14:17:44	3	1	163	22	5	62	1	111.40	56	97.12	CHANGED	MKhKKYIlAGTLAlLLuoTulssl-tNcAsASo..ph.hpspapcc+lA-EL+oLLsposVNcLAsGSLNsYYKRsIhhspY+AKuALKopsFspMu-AKhtLEpIYcEIDEhlpp	......................MKIKKYIlAGTLAlLLuoTulssl-KNEAsAST..ph.hpspYQcc+LA..-EL+oLLsp..osVN.cLAsGSLNsYYKRsIhhupY+.AKuALKoKsFcpMo-AKhpLEpIYsEIDEsL+S.......	1	4	4	5
+11379	PF11547	E3_UbLigase_EDD		E3 ubiquitin ligase EDD	Pollington J	anon	pdb_2qho	Family	EDD, the ER ubiquitin ligase from the HECT ligases, contains an N-terminal ubiquitin-associated domain which binds ubiquitin. Ubiquitin is recognised by helices alpha-1 and -3 in in the UBA domain. EDD is involved in DNA damage repair pathways and binds to mono-ubiquitinated proteins [1].	25.00	25.00	46.70	45.50	23.00	22.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.53	0.72	-4.47	3	94	2009-01-15 18:05:59	2008-09-03 14:33:28	3	7	74	4	61	100	0	52.30	84	2.12	CHANGED	suIPAuhVPEELIuQAQVVLQGKSRNVIIRELQRTNLDVNLAVNNLLSRDDED	.........slPAoslPEELISQAQVVLQGKSRsVIIRELQRTNLDVNLAVNNLLSRDDED..	0	21	26	44
+11380	PF11548	Receptor_IA-2		Protein-tyrosine phosphatase receptor IA-2	Pollington J	anon	pdb_2qt7	Family	IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene [1]. The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism [1].	20.50	20.50	21.20	21.10	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.85	0.72	-4.07	6	114	2009-01-15 18:05:59	2008-09-03 14:53:12	3	6	52	8	47	134	0	83.70	52	9.80	CHANGED	-EpaGYIlT-pcPLSs-cGl+LhElLAchl+lsoosFhslpVlGPAVTF+lRsNtQNloTADVsctAsssKspLEppoGL+ILQoGlup+s	.............t.EcaGYIlTcpcPL.oh.ttGh+LlEhLAchlchsousFhsISVVGPAlTFRlRpNp.QNlohADVsppAs...s...KscLEspTGLpILQTGVGpR..........................	0	6	10	24
+11381	PF11549	Sec31		Protein transport protein SEC31	Pollington J	anon	pdb_2qtv	Family	Sec31 is involved in COPII coat formation as it forms through the sequential binding of three cytoplasmic proteins: Sar1, Sec23/24 and Sec13/31. Sec13/31 is recruited by the pre-budding complex and polymerisation of Sec13/31 occurs to form an octahedral cage that is the outer shell of the COPII coat [1]. Sec13/31 is a hetero-tetramer which is organised as a linear array of alpha-solenoid and beta-propeller domains to form a rod in which twenty-four copies assemble to form the COPII cub-octahedron [1].	25.00	25.00	25.30	48.00	23.70	19.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.58	0.72	-4.32	6	24	2009-01-15 18:05:59	2008-09-03 15:43:24	3	6	22	1	15	26	0	50.20	66	3.95	CHANGED	sssPssssNVhSGQTPHLN+KANDGWNDLPLhVKEKPoRAKPVoVAPsuhh	......ss.PPh..NshSGQTPHLN+KANDGWNDLPLcVKE...KPSRAKAVSVAPssl...	0	1	7	14
+11382	PF11550	IglC		Intracellular growth locus C protein	Pollington J	anon	pdb_2qwu	Family	IglC protein is involved in the escape of F.tularensis live vaccine strain [1]. It has been shown that the expression of IglC is essential for F.tularensis to induce macrophage apoptosis [2]. IglC adopts a beta-sandwich conformation that has no similarity to any known protein structure [3].	25.00	25.00	55.40	55.30	21.20	17.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.27	0.70	-5.02	2	33	2009-01-15 18:05:59	2008-09-03 16:03:29	3	1	32	2	2	17	0	203.70	95	100.00	CHANGED	MIMoEMITRQQVTSGETIpVRTDPTACIGSHPpsRLFIDSLTIAGEpLDKNIVAIEGG-DVTKADSATAAASVIRLSITPGSINPTISIshGsLIKSsVRsKlpEKlSsILQASATDMKIKLGNSNKKQEYKTD-AWGIMIDLSNLELYPISAcAFSISIEPTELMGVSKDGMpYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAsu	..MSEMITRQQVTSGETIHVRTDPTACIGSHPNCRLFIDSLTIAGEKLDKNIVAIEGGEDVTKADSATAAASVIRLSITPGSINPTISITLGVLIKSNVRTKIEEKVSSILQASATDMKIKLGNSNKKQEYKTDEAWGIMIDLSNLELYPISAKAFSISIEPTELMGVSKDGMpYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAAA.	0	1	1	1
+11383	PF11551	Omp28		Outer membrane protein Omp28	Pollington J	anon	pdb_2r2c	Family	Omp28 is a 28-kDa outer membrane protein from Porphyromonas gingivalis. Omp28 is thought to be a surface adhesion/receptor protein. Omp28 is expressed in a wide distribution of P.gingivalis strains [1].	23.90	23.90	24.50	24.70	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.15	0.71	-4.74	4	100	2009-01-15 18:05:59	2008-09-03 16:20:42	3	2	61	2	16	103	108	175.20	19	45.94	CHANGED	Dshhhc.tsshpptatloGhPsshls.RcthhhS.shsh..hsashslhp....pstssslAIsSthsGpplsVTVpVth-pGso.sh+lV.lYlLENGLlhsQss............hGssl.sasHNcVLRtuhouhh.GDhhsshtshtthohuVslhhstuaNuENhslsAhVsDsss.pshss.+stlsspsDa	............................................................................................................sshPpshhs.R......p........th..h.......p...................t...tsh....t...t.pl...hp..............h.ss..s.....s..lsl.p..s.p..hs......s..s....p..hpls..lps.p...h...t.p.s.s...s.....t..h.+Lh..laLlEDulhu.Qt.s...................sssh..h..ps..Y...sHNHVlRs.....sl.s.u.sh....G-c.l.s.h..ts..ss....p..pshp..hshsls..p..s.h.s.....s......ps...hp...lVAalh....s..sss.....s.pshptth..........................................................................	0	8	15	16
+11385	PF11553	DUF3231		Protein of unknown function (DUF3231)	Pollington J	anon	pdb_2rbd	Family	This bacterial family of proteins has no known function.	27.70	27.70	28.10	27.90	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.75	51	448	2009-01-15 18:05:59	2008-09-03 17:01:37	3	3	139	2	115	456	0	159.20	22	94.95	CHANGED	hthhh.....ppsLsusElutlassh.ssshshslhptFhpsscDc-l+phlpcuhcl.upcalctlpplhpc-slslPpua..-s-Vssssss....FoDphhlhalphhspsulssYuhuhuhshRpDlthhatchhtchhphhpcshclhlc+Ghh.pPPhhsspccl	............h........sppcsLpssElhplWshhhssphshshhphFhppspDc-l+p.hlp.p.s.h.c.h.s.ppplcplpplLpppsl..sl.Ps...s...s...cssssh.s.s.ss.....asDthhhthl.shhh.t.tulsshutuhuts.hRpD.l.thhasphhhcphphspchhclhhcK.GWl...PPhh.....................	0	45	112	113
+11386	PF11554	DUF3232		Protein of unknown function (DUF3232)	Pollington J	anon	pdb_2rdc	Family	This bacterial family of proteins has no known function.	20.90	20.90	21.00	21.80	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.72	0.71	-4.30	3	14	2009-01-15 18:05:59	2008-09-04 09:07:04	3	2	14	2	7	16	0	125.40	28	65.53	CHANGED	MhQ.p..usVlSaVupahKuoEpsM-RYK+VlsIsKuDEVAl+LLEGLIDAuTRYFuKVVEMEpRLQTARFRLEGEELR-LTE-LDRSRRhAHEAhISSLHVFNRYlVKEYGE-LpEAGapGGIFP+PEAsRDRIAIAD..WAGELLoGIYE.sR++	.........................................t.h...........................................llpshhpphpcYshhVlch..-spltsh+.chsGp-YR-hsEpLD.+pRoshHssslSsl+ILNRhA-ppt........atss...ps-hsc.t.sIsc..at...............h.................	0	3	4	5
+11387	PF11555	Inhibitor_Mig-6		EGFR receptor inhibitor Mig-6	Pollington J	anon	pdb_2rf9	Family	When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains [1].The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive [1].	25.00	25.00	25.20	25.20	22.60	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.65	0.72	-3.58	6	119	2009-01-15 18:05:59	2008-09-04 09:35:41	3	9	40	6	49	99	0	64.70	64	8.47	CHANGED	+PPpVPPR-PL.SpssSRTPSP+u............................Lso..stlMPsTQSFAuDPKYsosKslQtQus-uu	...................pPP+VP..P...RE.PL.S.psSRTPSPhs.....................................LsS..stsMPsTQSFAsDPKYsosps..lQt.uscuu...........	0	2	8	18
+11388	PF11556	EBA-175_VI		Erythrocyte binding antigen 175	Pollington J	anon	pdb_2rji	Family	EBA-175 is involved in the formation of a tight junction, a necessary step in invasion. This family represents the region VI which is a cysteine rich domain essential for EBA-175 trafficking. The structure is a homodimer that contains a five-alpha-helical core stabilised by four disulphide bridges [1].	21.50	21.50	22.80	22.80	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.18	0.72	-3.88	11	128	2009-01-15 18:05:59	2008-09-04 10:54:31	3	10	18	2	19	138	0	77.90	58	8.31	CHANGED	lccTREcIIphSppNhCsNchS.cYCshhccchss.uTCSc-cpKsLCCSISDYCLKYFshsSpcYYsCh++EFpDPsYcCF	.lKsTREpIIhhSph.pKCNNslSlcYCsolcDKISS.sTCS+E+oKNLCCSISDaCLpYF-h.ShEYasCMK+EFcsPpYpCF.	0	5	7	16
+11389	PF11557	DUF3233		Protein of unknown function (DUF3233)	Mistry J	anon	Pfam-B_5068 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.50	22.50	22.70	43.60	21.40	22.40	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.98	0.70	-5.61	6	107	2009-12-15 10:43:27	2008-09-04 10:56:04	3	2	103	0	13	62	1	315.40	57	98.66	CHANGED	Mlphsh.....+l......s...huhlLlhstuspAcsh.ch.....lpsclEpsFooulVLoDS-sIThGIsDFDPNchlchcpps....hGos-SIphRpphoVYoLPa...ThsLo--.su.............apHpLpsRLShlpt-s-lplhsssu.oDsh+-psaGuhltYshpYploEsWTlssuhGsHLMaY+NsaoYNsch.pphtslLDGhhVNsSAhAhllEPNlchpYppcpsWGKWcasSoh+YFhGpuaGsAss.upsuNPcGWhlsNulphaYshschtctsQulYsphKRVDlGGDss-sLGTcHYYEhulGWLhssPphhphlDNlGIGlohNhGSAL+GGSIVLaFNc	..........................................................h.Sho...uoA...cS...h.Dh.....IQcaLEQAFSSSVVLSDSDVFTsGFNNFDPN-WFcsDN-N....LGTsESIEpRK+aKSSTLPh...TluLSE-.-A.............haQHQLFFRLSAsVID--LsIus..h.s.u...co-+aRpSVLGGulhYRYQY+LT-HWTLTPAIGTHLlYYRNohTYNNPphKh.L.hSsLDGLLVNThAWAsLlEsNlKlQY-EEKSWG+W+ASSuWHYFsGaGWGcANN.G-VGNPEGWYlANoLTGhYDF..TQlGRSVQSIYuSIKRVDVGusspEPLGToNYYEAShGWLMTPPFEh-hVDNIGlGLTFNYGSAhKGGSIVLFFNQ..........	0	2	4	9
+11390	PF11558	HET-s_218-289		Het-s 218-289	Pollington J	anon	pdb_2rnm	Motif	This family of proteins is residues 218-289 of Het-s, a protein of Podospora anserina. Het-s plays a role in heterokaryon incompatibility which prevents different forms of parasitism [1]. This region of the protein is the C-terminal end and is unstructured in solution but forms infectious fibrils in vitro which has a structure consisting of a left-handed beta solenoid which contains two windings per molecule [1].	25.00	25.00	30.00	28.90	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.86	0.72	-4.00	5	15	2009-01-15 18:05:59	2008-09-04 11:24:25	3	1	9	18	14	19	0	63.00	33	22.32	CHANGED	KlssIsVRN.s+cIpopEsAKV+LGNsaosuALusAIthsDRToNcs-oVpuKGsSsVHIGN+YG	...KlpsIsu+NpA+cIpsE-pA+lclGNsaSpssLspuht...lsDpTpNpV-sVsA+ssS+VpIGNpYG	0	0	7	13
+11391	PF11559	ADIP		Afadin- and alpha -actinin-Binding	Wood V, Coggill P	anon	Pfam_B017401 (23.0)	Family	This family is found in mammals where it is localised at cell-cell adherens junctions [1], and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules [2]. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.	29.90	29.90	29.90	30.10	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.66	0.71	-4.31	24	277	2009-01-15 18:05:59	2008-09-04 11:38:10	3	9	197	0	184	254	1	144.40	26	27.58	CHANGED	cpshpaINppLhohGasp.tthhsss............................phshstllNslasLlttpc+shctpEslppphpphpu-hpphpsshp+Lc.sphpthp+Ehs.thpppc+plpppl+shpppl+sp+--lp+hpshlpshcoQhsp-h+++-pEhpKLKc+Lpp	...........................................ps.pYlsppLh.shGh.p.hp..p.t..............................thshspllNsl.cLl.htp..c......+shptpEslpsphpplpu-hs+hpsphp+L........c.pplpptcRchs.thppp-pphpsph.....+..shpppl+pt+-...Elp+hps......hlpphps...Qhsp-h+++-pEhp+LKc+Lpp.........................................	0	61	101	146
+11392	PF11560	LAP2alpha		Lamina-associated polypeptide 2 alpha	Pollington J	anon	pdb_2v0x	Family	LAPs are components of the nuclear lamina which supports the nuclear envelope.LAP2alpha is a non-membrane-associated member of the LAP family which is unique. This family of proteins is the C terminal domain of LAP2alpha which consists of residues 459-693 and constitutes a dimeric structure with an antiparallel coiled coil. LAP2alpha is involved in cell-cycle regulation and chromatin organisation and preferentially binds to lamin A/C [1].	25.00	25.00	31.50	30.70	21.90	19.00	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.61	0.70	-5.18	2	25	2009-01-15 18:05:59	2008-09-04 11:50:26	3	3	17	2	9	47	0	209.20	60	33.77	CHANGED	AKoVVSHSLTTLGlEVuK..sQHDKI-ASE.SFPhHESILKVlEEEWQQlDRQLPSlAC+YPVSShEAspILSVPKVDDEILGFISEATPhuuhQAuSTESCsppLDLALCRuYEAAASALQIAsHTAFVAKuhQADISQAAQIlsSDPScspQALtILs+TYDAASYlC-AAFDEV+MuApsMGsuThGRRYLWLKDCKIs.ASKNKLsssPFKGGTLFGGEVpKVIKKRGNKp	..............AKTVVScSLTTLGlEhSK.QSQHDKIDASE.SFPhHESILKVIEEEWQQlDRQLPSLACKYPVSS+EATpILSVPKVDDEILtFISEATP.sGlQAuSTESCsKpLDLALCRsYEAAASALQIAoHTAFVsKAhQADISQAAQILSSDPo.cttQALsILS+TYDAASalC-AAFDEV+MuA+oMGsSTsGRRaLWLKDCKls.ASKNKLsssPFKGGTLFGGEVpKVIKKRGNK.......	0	1	1	1
+11393	PF11561	Saw1		Single strand annealing-weakened 1	Wood V, Coggill P	anon	Pfam_B03980	Family	This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyses the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates [1].	20.50	20.50	21.80	21.00	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.34	0.70	-4.95	9	45	2009-09-11 06:58:03	2008-09-04 13:11:48	3	2	41	0	30	45	2	210.00	28	91.69	CHANGED	Mssslshl+lusshllPlRlFlpR+plLt........sptshhp...lsppsIlpLpp.shplhLSpsDlpuLlspl+c-Ll.llhp.............................hppss.......hhshplpshcchs+hchpl+hhhphclslhl.shcclthlpph..h.h...................hsptstsLhhhspph.h............................p.ppstcp-...cK..lpaph+ssh...sltcsIclYVh	...MssplshlplspshlLPlRIFlNR+plLp.....................sp.o.suohhpt......P.lsspSIIsL+s.ss+IhLSppDhps.Lss-I+c-LLhIla.-hss....t.....................................................................................t...phl.c...l.hssspsp...phhssplpshpchsKhphpL+hctphclcIh.lsshccl.s.plRchlhh......................shs.ps.pL.hh.pph.h.....................hl.-stp.t..................t.pts.pp-.....K.....lpahhps.h....slschIclal..............................................................................	2	7	17	28
+11395	PF11563	Protoglobin		Protoglobin	Pollington J, Eberhardt R	anon	pdb_2veb	Family	This family includes protoglobin from Methanosarcina acetivorans C2A. It is also found near the N-terminus of the Haem-based aerotactic transducer HemAT in Bacillus subtilis (Swiss:O07621). It is part of the haemoglobin superfamily. Protoglobin has specific loops and an amino-terminal extension which leads to the burying of the haem within the matrix of the protein. Protoglobin-specific apolar tunnels allow the access of O2, CO and NO to the haem distal site [1]. In HemAT it acts as an oxygen sensor domain [2].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.62	0.71	-4.57	104	1086	2012-10-01 21:46:00	2008-09-04 14:07:44	3	53	846	19	390	1089	31	155.20	20	36.20	CHANGED	tpsclpthhpalshs...pcDhphLpphpshlpstlssll-taYpclhph.sphschhss......................psplp+h+pthppalpcl......hsus...hcttahcthpc.lGthHs............clslc.pahhushshlhptlhptlhpp............hshpchtthlpAlsKllhl-.slhhpsYhcstpp	...............................h.........thhths...ttphthltp.ht.thh.ts.phctlsppFY.ch.lt.p.p..Pc.h.tp.hlss.............................pps.hpcLK.pshpp..al.h.p.l......hsup........hD..p..c.a...l.p.h.p...pp...luphHs..............+IGls....schhhsuaphlhchlhthlhsp........................................................hs.htchhphhpshh+hl.lshplhhpsY.t....h..........................................................	0	140	270	329
+11396	PF11564	BpuJI_N		Restriction endonuclease BpuJI - N terminal	Pollington J	anon	pdb_2vla	Family	BpuJI is a restriction endonuclease which recognises the asymmetric sequence 5'-CCCGT and cuts at multiple sites in the surrounding area of the target sequence. This family of proteins is the N terminal domain of BpuJI which has DNA recognition functions. The recognition domain has two subdomains D1 and D2. The recognition of the target sequence occurs through major groove contacts of amino acids on the helix-turn-helix region and the N-terminal arm [1].	25.00	25.00	112.60	112.60	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.03	0.70	-5.46	2	14	2009-01-15 18:05:59	2008-09-04 14:28:20	3	2	13	1	3	15	0	256.30	42	61.35	CHANGED	M..sPEc..FRhph.Rs+hKN.l-NlLshhAs.Is.ls.hsKtpFspphNshlhphhGp.-pTcKTlsNaRTEIu.pLFGMhhEc-thlasusRspchhEDpD..tFFKshhapFpaPsGh.K.scllchsthtlQh+.h.YlLplhh...pA-ppsI.Loc--lAahlhNsLpshps+..slElhp+IhEsRusclshcs+..Gc.hpYu....+-.LsYh.lAsLlplpGshhKlN.hEtpsIN...pFhtscspFsuYt..h....To.-Dh+sFhpsW.pY...VNpchu	...Y.sP-cYaaRlHH.RPRFKs-lEsVLlahAspIS.ls.LscppFspphNphlppah....s.N....scps.pKTIsNWRTEIu.uLFGhhh......EcpG.hlh.suspApcLs-sQDL.cFFKpFhasFpYPuGHhKsppIlchhp.slpFK.....PspalLpLht...pu.cp...+..shhLTc-EluahlaNDLRsspc+pssh.Elhp+IhcNRtsclta-sp................GDVhRYA....pDILDYM.lAsLl.plpG.s..p....ahlNs.EppuIs...cahpssshFcsYsphht.tpsohc-l+phcptWF-Y...VNpt.........	0	2	2	2
+11397	PF11565	PorB		Alpha helical Porin B	Pollington J	anon	pdb_2vqg	Family	Porin B is a porin from Corynebacterium glutamicum which allows the exchange of material across the mycolic acid layer which is the protective nonpolar barrier. Porin B has an alpha helical core structure consisting of four alpha-helices surrounding a nonpolar interior. There is a disulphide bridge between helices 1 and 4 to form a stable covalently bound ring [1]. The channel of PorB is oligomeric [1].	21.10	21.10	21.10	30.60	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.33	0.72	-3.78	4	21	2009-01-15 18:05:59	2008-09-04 14:58:00	3	1	13	16	6	20	0	103.70	35	77.37	CHANGED	AtsAslsSo..sp-lsshhDhhsCsILcsuLstsGLscEspppsELAAsLcspus.........lG-hs.......suhuuclADRAQTCGIVcsD......TtLppLSSNLSS	...................u..Aslsss..spthsshlsshsCulLcs...uLtss.....G..lhcEsoTRsELAtsLcspus...ss..hsplsshs.......sshuuplADRA.TCGIVKsD.......o.Lp...tLSSNhSs..................	0	3	4	6
+11398	PF11566	PI31_Prot_N	Inhibitor_PI31;	PI31 proteasome regulator N-terminal	Pollington J	anon	pdb_2vt8	Family	PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces [1]. This is the N-terminal domain of the members.	18.50	16.60	18.70	17.10	18.20	16.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.94	0.71	-4.63	42	340	2009-01-15 18:05:59	2008-09-04 15:45:36	3	5	214	2	203	338	1	146.10	22	42.76	CHANGED	hh.htshpsslpsstDslshhlHhhhhps.sFchh...t........................lscspphpppp..........................t..lPttWst.s.ssYshpYtpsts..shpalLpshthssphllps...lshs.spphsshplsspcalst..................pptsshsshhpp.......hpcLhshhcpp................................................llp.lhsshpptth	..............t.......psshpsspDulhhhlHhhhlps.Gahhh...s........................hscssphpstp...........................................hhP.ppW..st..spssYshpYtcs...........s...stphllpshh.hss.tlllss.........lsht..scplpplpl.psccalsp..............................pp.sshsph.hts........................hpcL.phhcsp................................................ll..lhsthpp.....................................................................	2	59	93	148
+11399	PF11567	PfUIS3		Plasmodium falciparum UIS3 membrane protein	Pollington J	anon	pdb_2vwa	Family	UIS3 is a membrane protein essential for sporozoite development in infected hepatocytes. This family is 130-229 of the Plasmodium falciparum UIS3 protein which is compact and has an all alpha-helical structure.PfUIS3(130-229) interacts with lipids, phospholipid lysosomes, the human liver fatty acid-binding protein and with the lipid phosphatidylethanolamine. The interaction with liver fatty acid-binding protein provides the parasite with a method to import essential fatty acids/lipids during rapid growth phases of sporozoites [1].	25.00	25.00	118.90	118.00	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-3.86	2	9	2009-01-15 18:05:59	2008-09-04 16:22:46	3	2	8	6	6	11	0	97.60	57	46.07	CHANGED	INKlNlpt.lhENpNslDlslKRaN.FhD.s+LuhQ+HFpcLSN-Q+c.hlNsh-YhpKhVQsLpEsRslslSKhQEshAVhslcaaLpc.Y.....Qpc.	INKVNlKG.LhENsN-lDVPlKRFNhFhDNs+LAhQHHFscLSN-QpcYhlNDhDYlRKlVQoL-EsRNlslS+hQEDhAVLslEaFLpc.Ytp............	0	1	2	5
+11400	PF11568	Med29		Mediator complex subunit 29	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators [4].	25.00	25.00	27.50	27.10	24.50	23.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.99	0.71	-4.15	7	108	2009-01-15 18:05:59	2008-09-04 16:40:37	3	2	83	0	61	99	0	135.60	45	69.25	CHANGED	p-ch....Dsls+VKsLl.ssLR-Sl.phhKpuAphLpQNp..Ds...pptpst-ssh.RF-KsLE-FaAlCDQlElsL+TAhpChpQtss........Ss+alPs.Vhss.....spsssh..sslsYspYLssVpspIppAKDIHcsLlssupplsst...........-	..............................................pch....Dslp+hKhLl.s.L+ESLp...shhKsAApsLhQNsslDNG.....tKuuD.s.slp........RFDKsLEEFYAlCDQlE.....LsL...+hAhECLo.Qsss........Ss+a.Ps.Vsss.....spsssspsssLsYsQYLssl+uQIssAKDIHssLlssupplssp......................................	0	19	24	45
+11401	PF11569	Homez		Homeodomain leucine-zipper encoding, Homez	Pollington J	anon	pdb_2ys9	Family	Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus [1]. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerisation and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain [1]. Homez is involved in a complex regulatory network [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.89	0.72	-4.91	9	166	2012-10-04 14:01:12	2008-09-04 16:47:08	3	12	50	1	72	289	0	52.90	41	7.20	CHANGED	sh.ssscsl....Lp-YYhpH+hLpEpDLDsLspKSpMShpQV+-WFAp+.pcpscs	.....................h...sspth.....LccYY.h.p.H.+...h...L...pE.pDLspLss+SpMShpQV+-WFup+..c.s..t..........	0	6	10	31
+11402	PF11570	E2R135		Coiled-coil receptor-binding R-domain of colicin E2	Pollington J	anon	pdb_2ysu	Family	E2 is a DNase which utilises the outer membrane receptor BtuB to bind to and enter the cell. This family of proteins is E2R135 (residues 321-443) which is the part of E2 which is responsible for binding to BtuB in a coiled coil formation [1].	22.80	22.80	23.00	23.30	21.90	22.70	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.88	0.71	-4.07	2	37	2009-12-15 10:45:41	2008-09-04 17:03:58	3	11	21	6	3	46	1	126.60	56	19.71	CHANGED	HP.EuhcRpY-+A+AELsttscslAp.ppR.Aps.pshsut+utlptAsKplt-..AEhpp.DhhsasP.tthtphWQ....psphhppDlpNpptthcAAtpphs-hs.......AALSuA.EpRKQKEpKtKDAcsKLs	...............HP.EuhcRsY-+A+AELspAsc-lApsQpRpApAlps.......hsuR+SELDtAsKslt-h.AElKph-RFA+-PMAuGHRMWQMAGLKAQRAQTDVNNKpAAFDAAAKEKuDAD.......AALSuA.EpRKQKEsKc+DAcsKLs.......................	1	1	1	2
+11403	PF11571	Med27		Mediator complex subunit 27	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells [4].	25.00	25.00	25.70	26.20	22.90	24.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.38	0.72	-3.86	18	176	2009-01-15 18:05:59	2008-09-04 17:06:26	3	3	146	0	120	170	0	91.90	36	25.59	CHANGED	shpths.apsSc............hplapclospsppAlhphhs.sp.tthsltphhsaIpSY...pslFssPCs+Cs+hl.....ptt.LP.....PshR..shss........h-saHpsCh	........................ts..thshastSp............apVFp+lo-+ApsAl.laah.....sphPc...hs.....l+shhsWlpSY...hpLFpsPCp+CG+hL......pstLP.....PsaR..chpo................................hEAaHpsCp................................	0	38	55	93
+11404	PF11572	DUF3234		Protein of unknown function (DUF3234)	Pollington J	anon	pdb_2z0r	Family	This bacterial family of proteins has no known function. Some members in this family of proteins are annotated as TTHA0547 however this cannot be confirmed.	20.20	20.20	22.30	45.80	19.40	18.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.39	0.72	-3.90	2	11	2009-01-15 18:05:59	2008-09-04 17:08:03	3	1	11	12	5	9	0	103.50	64	98.53	CHANGED	MAPDLSGTWYVLEGDPGEHLVVEALGERLSGIWTSRELAEAFLAHHPHLGMRVSALESRALKEAaLRALGMLQVEAVMVDYRPGTHRAQVARVKDLLEEVRRA	.....MtPDL.SGTWYVLEG..-..PGEHLVlEALGpRLSGIWTScELAcuFLA+.HPc.L.GMRVSsLESRALKEAFLRALGMLpVEAVhVDYRPGoHRAplARVc-LLEEVRRA.........	0	1	3	5
+11405	PF11573	Med23		Mediator complex subunit 23	Coggill P	anon	manual 	Family	Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.	20.60	20.60	28.40	20.80	18.80	20.00	hmmbuild  -o /dev/null HMM SEED	1341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.02	0.69	-14.13	0.69	-7.23	7	204	2009-01-15 18:05:59	2008-09-04 17:13:51	3	8	102	0	133	209	1	793.90	37	84.96	CHANGED	Ms........ppllch.-p..........hlcsp..p....s......ps.psphtphst.....hsshhuthtpcp+pphl+.hlhhltthsp.p.........phchhhp.Lhchsttthl.uphLCtphh..pp..h.ppphh.Epa+hl+csIstlDYKGlRpIh+hhhE.phhphP.slSsphlsplhtlp-ll.+Ih-RsusLLPAYhslsEIh+shshps.h...W+Lsphlush.pcFRslAphhoIhG+sshLPIVpHs.....uatsthhs.Wclc.sshph.hpup..LPYcP-h.hpsQhhLLpaVLcQPYS+DMlsshhshp.pp+pppsshEp.LshllhpAMEpoEspspp.................pstspalW.HLos.lIYhlhapasshtshlpsL......+pKlstpplpRuRDclMWllLQalSuuhphstIss.hh.lhcLas.LYs-c..psl.lP-.sssphs+thAssClWhHL.KcAtscp.phscsIPpsLKhpaEhLpp.....ss.sh..ts-aplAlLsNAYSTsschFspsMssLh-sl.usscssps......uh.h.As.shsshshphLDuLTh+uKhSLl+pIlshhhp.upsKtssP....husALlETYsRhLVYpElESLuh+uhhuphh.......P.....pshpspAhs.LahLhEhhuYRhHHlpsah+hQh.....LoahpsLsulspssphQlapslEsssLRLI.............ptlGSsphpsp.shhlpc.c.PtslsSs........sEELN+sLIholARuh+lT....stss.upshsc-hLtsIhphTPasWsp+oLppFP.shp-hhpQpshsp.tsp.t.hhos--EhtphsoMpsEN-lIt+Fups...sssPlFLCllFKhl..h....pTpsIoshhYclLE+hus+slssplRphsDallhElusotsst.plpKsl.cslspMlW+aNllshDRllLsLhhRst-us-AQlsh.IhQLLLLp......ss-FppRlp.Fhpp.ss.-HappssahctHlsaHppFPEph.h-tssppsp.........LPlYFGNVChRhLPVlDlhlHRaLEh..hplsp....LtslLDplu.LYKFHcpPITalYsTLahacthhps+s..KKpLVsslhuplc-sRP..WsLoEtYpta.hppppsp..W.P-.sYahpLlcRhssolDuhs.....sFsupDWRasEFsNPsApALYloClELhuLPsuPptVsNulIsVllps.sllP.t.l.sahNslGLlhsALPpsYhssla-chhpslsssphtshp..h..sF-.FsFcshcpuhL-....pshssllslupuhapHhulupLsshscphh.plh.hV+TEhpLlYlh+lVGPaLpRh..........hpptcshuslslhhh.h.c.sshsp.uh.l.Y.s.lCDhhYphKYhFsG	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................W..h.s.hh.h.hh.t..hs..phh..l.......thh................p.p.lhWhhhphht....h.....................................h..sp.t..........h..h...s.....h.....h...t........................................................t..................t...hhhh....p.........h.hh.p...h..........................h.shshthls.....shohp.p..h...h.......h..........t...s............s.thh.Thsh.hhh.....phh.+.hhsth...............h.p.t...t..hhlhEhhsaRh...........h.....+.ph......L.h..hp.h..s..h...s..p.ht.p.pl.hhhEshshpLh.......................shhss.h...ts....hh.p...stthhp..................pLNRhhlholAhsh+hp.........t......hh..phLtplht.o...at....Ws.pohthFP..h..pt.hh..t...........p..........s................hts..p..p.hh.p.h.................tt.thl.pa.......................hLChhhhhh..h....p........s.....h.h..phl......pt..........hssptls.tl.hhsDhll.....ch....t.........t.t.........h....psh....t....ls.hlaphpllshDhhlLsLh.+s..cs..............ps.h...lhp..llp.......s-h.p.Rlp.ahp...s.cc...a......h.s..ph.pp..th.t..s-....p...t................................................................hPhaasslshRhLPlhslhlaRhlE.....h.p.......lLthhu.hhta.H.s..hoalhshL.hha...h...th..............Ll.thh.s.hp...p........hop.a.......t..........................pahhtLl.th............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	62	75	111
+11406	PF11574	DUF3235		Protein of unknown function (DUF3235)	Pollington J	anon	pdb_3b4q	Family	Some members in this family of proteins with unknown function are annotated as RpfA however this cannot be confirmed.	21.10	21.10	21.90	22.10	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.28	0.72	-3.75	4	59	2009-01-15 18:05:59	2008-09-05 09:48:56	3	1	57	2	13	35	0	89.20	47	42.43	CHANGED	GLNSAPTPRslsAsst.PtPAsAAPA.stEYsAssshNoN.l.......sVcuhYsAlsspLAphGlsVPsElpuaYNA..................hlu	GLNSAPTPRDss.Ass..PA.......Ps.pssss..sQphA.Asuu.su-cL...........................AVDAlYsAlcsRLA...uhGluVPsplcuaYpAN+s.sFsuFYtANRtsIDhhh.h..................	0	2	8	13
+11407	PF11575	FhuF_C		FhuF 2Fe-2S C-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_11690 (release 9.0)	Domain	This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.\	     FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B [1].  This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster [1].	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.89	0.72	-7.19	0.72	-4.27	60	1049	2009-01-15 18:05:59	2008-09-05 10:52:59	3	4	988	0	178	640	12	22.30	54	8.86	CHANGED	RcsCClhYpl..sus.ph..Css.CP..hh	..RRoCC.cY+l....Pss..pp......CGD.CsLh....	0	35	93	140
+11408	PF11576	DUF3236		Protein of unknown function (DUF3236)	Pollington J	anon	pdb_3brc	Family	This family of proteins with unknown function appears to be restricted to Methanobacteria.	25.00	25.00	121.40	120.20	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.79	0.71	-4.81	7	27	2009-01-15 18:05:59	2008-09-05 11:05:31	3	2	27	2	19	28	0	154.70	53	91.72	CHANGED	lE-hIppAahEShpstRhGDctEElctIpphIpsA++lVVsspNpcKhcVlpcllpchs.scsphLpIsTN.ADLTRhPAloKuLhAlDlocADllIARGRLGlPGSGShLlIMDp+GRlLTuuhSPSplIHppslc-ulppEhpcALpRIGhp	..hEchIKpAYhESlpspRhGD+hEElctIpphIhsAK+IVVsTpNpKKFcVlp-llpcl..........s.......splphLpIsTN.ADLTRMPAlsKuLhAlDhscADLlIARGRLGlPGSGShLlIMDsKGRILTuulSPSplIHKpslEcsVcpEhhcALcRIGl..	0	4	9	15
+11409	PF11577	NEMO		NF-kappa-B essential modulator NEMO	Pollington J	anon	pdb_3brt	Family	NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation [1]. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK [1].	21.00	21.00	21.00	23.10	19.90	20.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.28	0.72	-4.22	9	160	2009-01-15 18:05:59	2008-09-05 11:12:20	3	2	60	4	67	138	0	66.90	46	14.09	CHANGED	.tpslpphpcLlpENppL+EAlKQoNptMK-RaEELttWpE+Q+EER-Flpp+hcEA+phlptLshEN	......pth.pphpchLpENppL+...-Al+QsNQhh+cRhEEL.taptpQ+EE+-Fh.p+FpEA+chlppLohEp....................	0	9	17	37
+11410	PF11578	DUF3237		Protein of unknown function (DUF3237)	Pollington J	anon	pdb_3c5o	Family	This family of proteins has no known function	21.60	21.60	22.10	22.20	20.70	19.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.79	0.71	-4.91	66	476	2009-01-15 18:05:59	2008-09-05 11:23:30	3	11	281	12	270	484	95	145.20	24	71.09	CHANGED	PsL..chhasl........pl.......clsssh.....slGp..................sstG........pRpl.lsls..GGphpGs......plp.......................GplLs.sGuDathlp.s-G...........................hscl-sRasl..cTc..........DG......shIalpspGhhpss......thhp.thtt...upslss......s.phah................+ss.pFETu.s.s+Y.pWLsptlhVG....pupptss.t.....VhhcsapV	...........................................PtLphhhph........pl.........pl...ss.sh.....tlGp...............................ss.t.G........pRph..lslh....GGphpG..........tlp.....................................G..plls...sGuDath...hp..sss............................hscl.cs+Yhl....pTs................DG.....shIhlpspGhhp.ss...t.hht..htt.......spshs.................s..phhh..................pss...pF..ETu..s...tcY.paL.sp.tlalG..puphh.ss..t.....Vhhchap...........................................	0	46	135	217
+11411	PF11579	DUF3238		Protein of unknown function (DUF3238)	Pollington J	anon	pdb_3c5p	Family	This family of proteins with unknown function appears to be restricted to Bacillus cereus.	19.80	19.80	20.00	19.90	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.29	0.71	-4.67	2	116	2009-01-15 18:05:59	2008-09-05 11:29:37	3	2	59	6	10	87	1	181.60	58	86.79	CHANGED	MspIVKlRuSVFhPhuhhEPhKDstTG+lhpatGDuREFTPaAsNshRSRlEQEVslDFYKcElFoYAsssIsT.KlTNPDGSsphppGchSTENIVCTsIsWspDtVpFcMpASASNPLNshAPssDYLLslpVNKsGolclpG.HDGFPCaEFYKQVDFGsFEpIYhHDFRETsDTPtALuGEM-YSFpppl	..................................MspIVKlRuSVFhPhuhh.....E.shKD.t.TGplhpatGDuREFTPaAVNo..hRSRlEQEVllDFYKcElFoYAsssIs..T.KlT......N....P.DGSlphcpGcs.STE.N.IVCTsIlW.ss-.tVpFcMpASASNP.....LNshA.PssDYlLslpV.p+s.GolclpG.HDGFPCaEFYKQVD..FGs.FEpIYTHDFRETsDTsAALuG-M-YSFpppl.........................	1	1	7	7
+11412	PF11580	DUF3239		Protein of unknown function (DUF3239)	Pollington J	anon	pdb_3c8i	Family	This bacterial family of proteins may be membrane proteins however this cannot be confirmed. Currently there is no known function.	25.00	25.00	25.30	27.10	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.57	0.71	-4.11	7	82	2009-01-15 18:05:59	2008-09-05 11:49:43	3	3	81	2	19	66	0	124.90	42	54.56	CHANGED	P+phGshppLYsphpLsPAlluElsPRslVLLuLVsssssssspspaALssRslsplsGhs...++lGpRVPuVAlp....utcshcst-pW-plSPMPIsWGTsDssVlcRAEpsIsps.WspLppslspl-c	......P+pVGsAppLYssYsLsPAhIAEVNPRDhVlhALVNsssD.spss.P.....paALssRsloslsGhc...RpVGpRlPsVAVs....Gppospsp-pWppISPMPIuWuTsDssVlp+AtcsIPpcpWphLp+sls+l-.p...	0	3	13	18
+11413	PF11581	Argos		Antagonist of EGFR signalling, Argos	Pollington J	anon	pdb_3c9a	Family	Argos is a natural secreted antagonist of EGFR signalling which functions by binding growth factor ligands that activate EGFR by forming a clamp like structure using three disulphide-bonded beta-sheet domains [1].	25.00	25.00	28.00	26.70	18.80	23.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.92	0.71	-4.19	3	39	2009-01-15 18:05:59	2008-09-05 12:56:11	3	2	23	8	25	50	0	93.60	46	41.30	CHANGED	HSlKDlRILYQVGsSEcDLPV...........................CAPNAV.....................CSKI....................DLYETPWIERQCRCPcuNRsP.plIlHHHc+ssuo	......................................................................................................Cp.asVpp+..-.hh-ps.Ipp.CpCPcuaRCP......pHHopsu.........	0	7	8	19
+11414	PF11582	DUF3240		Protein of unknown function (DUF3240)	Pollington J	anon	pdb_3ce8	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.13	0.72	-4.07	11	148	2012-10-01 21:59:08	2008-09-05 13:09:45	3	2	146	1	47	234	49	95.10	29	92.06	CHANGED	hopphh.LsLlhs+-l+s-LsDhLhph.DhlSGFTlhcssGaupchphhshuEpV+GttctltlpllhsppshpplLspL+pthscssltYWltPVtshGpls	...............................h.....h.LplhhshsL+DsllDh.Lh.cp..s.h.ssFhhhpshuaus..p...p...h...h....hS.......pE.QVpG+...p......chsphclhlscptstsLlpsLcpph..sspth...hah...........t....................	0	10	34	40
+11415	PF11583	AurF		P-aminobenzoate N-oxygenase AurF	Pollington J	anon	pdb_3chh	Family	AurF is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalysing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes [1].	25.30	25.30	25.30	25.30	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.88	0.70	-5.50	33	580	2009-01-15 18:05:59	2008-09-05 14:47:50	3	1	308	10	194	533	184	282.80	21	88.21	CHANGED	M...........................spppshppLhcu.sc+uh...cPh....p..........sss+ahhPsphssLhssshapphspppphclsppchhshhssslhFEshlh....ptlh+shhstsssssptphshptlsDEshHslMahchhppls............ss.hphpRhhphlhphhsshh.pshstahsshluEphlssh.+shhcDsp.lpPhl+plhplHlh-EuRHhpFuc-hh+phhsph..sttpRthhushlshshthahss.lp.thhtts......slcstcultpsh..sssptt.phh+shhuslhphhccsGlh	........................................................................................................phhtpL.cu.usp.csh...sPhh.-lDWpss..........sssphhhssph.s...Lhs.pshapphsccp+hclspachushhshslahEp.h.Lh....phlhpphht.t.s...s.s.s.s.php.a.sh.s.p.hsDEspHshMFtch.l.p.+hs................sshhth..chhp..h.l..ht.h.............h.s..s......sh..hs......hshass....h.ll...uE-h.ls...ph...p..+...ph....hc....Dsp..l.pPhh+plhplHlh-EARHluFu+....chl....ccth.sph......sphpRt....h.hphh...hsh.sht.hh.hps.h..hs.st.hhhhh......shs..cshtpth...tssp.p..phhpt.hhtplh.hhcchGlh..................................................................	0	49	126	168
+11416	PF11584	Toxin_ToxA		Proteinaceous host-selective toxin ToxA	Pollington J	anon	pdb_1zld	Family	ToxA is produced by particular Pyrenophora tritici-repentis races and is a proteinaceous host-selective toxin. It is necessary and sufficient to cause cell death in sensitive wheat cultivars [1].ToxA adopts a single-domain, beta-sandwich fold which has novel topology. The protein is directly involved in recognition events required for ToxA action. It is thought to be distantly related to FnIII proteins, gaining entry to the host via an integrin-like receptor [1].	25.00	25.00	25.10	256.70	18.40	17.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.72	0.71	-4.25	2	16	2009-01-15 18:05:59	2008-09-05 16:00:25	3	1	6	4	2	14	0	117.80	97	67.67	CHANGED	QGSCMSITINPSRPSVNNIGQVDIDSVILGRPGAIGSWELNNFITIGLNRVNAsTVRVNIpNTGRTNRLIITQW-NTlTRGDVYELFGDYALIQGRGSFCLNIRSDoGRENWRMQLEN	QGSCMSITINPSRPSVNNIGQVDIDSVILGRPGAIGSWELNNFITIGLNRVNANTVRVNINNTGRTNRLIITQW-NTLTRGDVYELFGDYALIQGRGSFCLNIRSDSGRENWRMQLEN	0	1	1	2
+11417	PF11585	Stomoxyn		Insect antimicrobial peptide, stomoxyn	Pollington J	anon	pdb_1zrx	Family	Stomoxyn, localised in the gut epithelium, is an insect antimicrobial peptide which functions in killing a range of microorganisms, parasites and some viruses. Stomoxyn has a structure consisting of a random coil in water however in TFE it adopts a stable helical structure. Stomoxyn is thought to have a similar function to cecropin A from Hyalophora cecropia due to structural similarities [1].	25.00	25.00	26.20	102.30	23.30	18.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-8.13	0.72	-4.16	2	2	2009-01-15 18:05:59	2008-09-05 16:08:59	3	1	1	1	0	3	0	42.00	81	62.69	CHANGED	RuFRK+FN+hlKKlKHTISETAHVAKDsAVIAGSGAAVVAAs	RuFRK+FN+hlKKlKHTISETAHVAKDsAVIAGSGAAVVAAs	0	0	0	0
+11418	PF11586	DUF3242		Protein of unknown function (DUF3242)  	Pollington J	anon	pdb_1vr8	Family	This protein from Thermotoga maritima is a hypothetical ORFan protein, TM1622, whose structure has been determined. The protein is composed of seven beta strands and three alpha helices [1].	25.00	25.00	134.20	134.00	22.70	20.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.81	0.71	-4.60	4	11	2009-01-15 18:05:59	2008-09-05 16:31:12	3	1	11	1	5	12	0	129.20	42	81.71	CHANGED	PpuYSlcoAlhlLps.pYhLssVtcl.-uYGsl..ucGhsA..lF-shsGhFalFKYhsEp.AKp.WKKlsKchGhs.phsYh..shhshGhFos+h-upcIlsWWKDNWLFllpGcs.s--FspaV.clYtclK	PcuYSl-oAIhlL-s.cYhLsDlcEI.DuYGDV.phKG+VA..lF-scpG.hlalatYcuE-.AKphWKKlsK+hGhsShRohL..-LsshGhFSThh-GKcIluWWKcNWLFllEG+sslE-FVcaVhcVYpclK.	0	2	3	5
+11419	PF11587	Prion_bPrPp		Major prion protein bPrPp - N terminal	Pollington J	anon	pdb_1skh	Family	This family represents the N-terminal domain (1-30) of the bovine prion protein (bPrPp). The proteins structure consists of mainly alpha helices. BPrPp forms a stable helix which inserts in a transmembrane location in the bilayer, with the N -terminal (1-30) functioning as a cell-penetrating peptide [1].	20.80	20.80	20.80	21.60	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.96	0.72	-7.02	0.72	-4.28	8	461	2009-01-15 18:05:59	2008-09-05 16:47:14	3	6	190	1	19	408	0	28.10	83	11.54	CHANGED	Mu+..luCWlLVLFVAsWSDVGLCKK.PKP	..MVKSHlGuWILVLFVAhWSDVGLCKKRPKP.	0	1	1	4
+11420	PF11588	DUF3243		Protein of unknown function (DUF3243)	Pollington J	anon	pdb_3d0w	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	20.00	20.00	20.00	21.90	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.58	0.72	-3.99	17	247	2009-01-15 18:05:59	2008-09-05 16:59:24	3	1	189	4	63	156	0	80.70	49	91.39	CHANGED	MslL-s.a-pWKsaLucplppupptGhsccslschAhplG-YLAppV-PpNpcE+lLp-LWcVAs--Ep+sLAshhVKlVpp	...........................MoVL-N.FDpWKsFLG-RlcpApptGLsptsluchAaclGD.YLAscVEs+NcpE+LLtELWcVADEpEQHsIAslMVKhVpp....	1	25	49	53
+11421	PF11589	DUF3244		Domain of unknown function (DUF3244)	Pollington J	anon	pdb_3d33	Domain	This domain adopts an immunoglobulin-like beta-sandwich fold  and structurally is most similar to fibronectin.	22.00	22.00	22.00	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.26	0.72	-4.33	10	185	2010-07-04 00:38:26	2008-09-05 17:09:39	3	9	75	3	38	154	25	101.30	21	65.17	CHANGED	s.ohpphs+......slshcGcW....t-cttRSI.sslP.oASI..DGslLsIcFpsslsslTIslpc.ppGsVlYEsslssusuptholSlsshssGcYplclopstG.aLhGpFhlE	..................................t......................h.....t..t....RSl....hPhp.s...l...-..s..s..h..l.pl.pF.t.p.shss.l.s....lplps...psGpll.Ypsshss.s.ss.t.h.sIsL.ssh.s.sGpYpLplpssps.hh..hGpFp...............	0	18	33	37
+11422	PF11590	DNAPolymera_Pol		DNA polymerase catalytic subunit Pol	Pollington J	anon	pdb_1dml	Family	This family of proteins represents the catalytic subunit, Pol, of the Herpes simplex virus DNA polymerase. Pol binds UL42, making up the DNA polymerase. UL42 is a processivity subunit which binds to the C-terminal of Pol in a similar way that the cell cycle regulator p21 binds to PCNA [1].	20.00	20.00	21.90	34.10	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.79	0.72	-4.28	8	108	2009-01-15 18:05:59	2008-09-08 09:10:44	3	2	21	4	0	170	0	36.70	78	3.03	CHANGED	c-sAtRLsuAGFsslpuGA....spEEETRQ+L++AFcILA	.DDVAARLRAAGFGslGAGA.....TAEETRRMLHRAFDTLA	0	0	0	0
+11423	PF11591	2Fe-2S_Ferredox		Ferredoxin chloroplastic transit peptide	Pollington J	anon	pdb_1fct	Family	The structure of chloroplast ferredoxin in water is unstructured however in a 30:70 molar-ratio mixture of 2,2,2-trifluoroethanol, residues 3 to 13 form an alpha-helix. The rest of the peptide remains unstructured [1]. This family is the N-terminal of the [2Fe-2S) ferredoxin from C.reinhardtii. This protein catalyses the final reaction in a pathway which allows the production of H(2) from water in the chloroplast [2]. 	25.00	25.00	62.90	62.20	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.64	0.72	-4.31	2	6	2009-01-15 18:05:59	2008-09-08 09:34:00	3	1	4	1	3	4	0	33.00	80	25.98	CHANGED	MuMAhRSoFAARV.GA+PAVRuARPuuR.hSs.A	MAMAMRSoFAARV.GA+PAVRuARPuuR.hSs.A	0	1	3	3
+11424	PF11592	AvrPto		Central core of the bacterial effector protein AvrPto	Pollington J	anon	pdb_1r5e	Family	This family of proteins represents the bacterial effector protein AvrPto from Pseudomonas syringae. This is the central core region of the protein which consists of a three-helix bundle motif. AvrPto is part of a type III secretion system from P.syringae which is involved in the bacterial speck disease of tomato. In resistant plants, AvrPto interacts with the host Pto kinase, which elicits an antibacterial defense response. In plants lacking resistance, the Pto kinase is not present and AvrPto acts as a virulence factor, promoting bacterial growth [1].	21.80	21.80	24.10	61.20	20.40	15.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.24	0.72	-4.26	2	21	2009-01-15 18:05:59	2008-09-08 09:57:52	3	1	19	2	2	19	0	105.30	53	65.34	CHANGED	DNVTSsQLLSVR+QLAESAGLPRDQHEFlSSQAPpSLRspYNNLYSHTQRTLDhADMQHRaMTGASGINPGMLP+ENVDDMRSAIoDWSDMREALQHAMGIHADI	.....s.sVTusQLLsVRHQLA-uAGLPR-QHcFIoNp.APpoLRsRaNsLYs+TQRTLchADhQHRYMTGsSulNPGMhPHENVssMRoslScWSDMREALQHAMslHssh...	0	0	0	1
+11425	PF11593	Med3		Mediator complex subunit 3 fungal	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [1]. Mediator subunit Hrs1/Med3 is a physical target for Cyc8-Tup1, a yeast transcriptional co-repressor [2].	27.60	27.60	27.70	27.70	27.20	27.50	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.49	0.70	-5.22	5	30	2009-01-15 18:05:59	2008-09-08 10:35:47	3	3	26	0	19	34	0	319.90	39	85.24	CHANGED	DsILsssloL--Lc-hLu.csEu.o+DsVsc+IpcA+DuILPLRLQFNEFlpllSsI..EchuspTsQEKFLhIRSKLL-Lpc+lQsLSpDFcpLQPLFsTVsEYScTh..+-KKFQlLETL.............................GoYscsussuASsShspsSs+SsAATTuSTAsTPuA..AslssApoAus.........PssTssl.............Gos.ssss.h.soTsssshstsKKPRKPRQTKK.....sAsAAKsQ..............ASAsAsAsAuA.sp............................................ssh.tss.NuuMtsslPN...sTPs.Mt.....lsusSP.........s...............NuMuSPL......NsMSPMpNhsQ....MGt.s.h...GQhs.sss.GstsspsspsshpussTPStSM...hN.NNITPANILNMS.........s.uF-p.sQsQsPQQttsQsQ.pshNMsM.sDsNN....hD.lDLNNLDLuSLNMDFL	....................................spllssslpL--LpshLA.p..........s-s.s+DpVsppIpcsccpILPLRLpFN-FlphMusI.......-t.ppssp.tKaLhIRsKlLpLss+hQsLSpchptLQPLFsTlsEY.coh..ps+pFp.LEsL.............................uohscsusAssSsu...tshsos+SsAAo.TsoTssTPtA....sshsp..upohss.........Psoossh.............uos.sTss.stsoTs.ssshsssKKPRKPRpTKK..............ApsQ......................spApApApAQs.tpp......................................ss..psshsuuMsuslPN...sTPs.M........lNusSP..........p..............NsMuo.PL......NhMSPMsNs.p....hGt.s.t...uphp..t...us.hss.s..sshpts.ss.ps....hs.NslTPANILsMs.............................shpp.pQ............p...p...th...s.Ns.......lDLNsL-LuuLNMDFL.........................................................	0	2	7	16
+11426	PF11594	Med28		Mediator complex subunit 28	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours [4].	23.40	23.40	23.40	26.50	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.50	0.72	-3.80	3	97	2009-01-15 18:05:59	2008-09-08 11:35:36	3	1	79	0	66	90	0	102.40	48	51.22	CHANGED	EIRstVDQsopKF..LDIARQpEsFFLQKRhpL..SVhKP-plLKEEsp-LK...pEl..........QRKDpLl.............pKHhoKI-aWcNL...LoDtpshaKshs-lPs-GRtslsE.uo...............uslPus.c	..........EI+stV-Qshp+F..LDlARQhEsFFLQKRhpL..Ss.KPEpllKEDlsEL+...sEL.........................QRK-sLl....................QKHhsKLcpWQpl...LpDlpsttc..tp..h...h..t..............................h...................................	0	17	22	45
+11427	PF11595	DUF3245		Protein of unknown function (DUF3245)	Wood V, Coggill P	anon	Chahwan C	Family	This is a family of proteins conserved in fungi. The function is not known, and there is no S. cerevisiae member.	26.40	26.40	26.60	27.20	26.10	26.30	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.03	0.71	-3.93	12	68	2009-09-11 06:21:26	2008-09-08 13:01:24	3	3	59	0	51	64	0	134.70	31	67.63	CHANGED	KssVuLu+oQ+LluSWLss.osstpups.ps-pELQp...c.hpsVPppLGlGAslPppuscu..o.pp.cLsS.....sDcL++QLLGKshp+hhutttt.....s.s..pppuss.ssptsspsstht--sD-DD--.EuRouhhu+pt...........+KR+	........................tsVuLu+up+LluSWlsshossc.tsss.csEpEhp...tthh..ps.hPc+LGLGAs.lPppttcu....s..t...tS.....sDcLc+pLLGK.............................pppsst.tttppppst..sscps---DE-.EuRouhhu+pp....................t...........................................................................	0	13	25	40
+11428	PF11596	DUF3246		Protein of unknown function (DUF3246)	Wood V, Coggill P	anon	Chahwan C	Family	This is a small family of fungal proteins one of whose members, Swiss:A3LUS4 from Pichia stipitis is described as being an extremely serine rich protein-mucin-like protein.	27.80	27.80	96.00	30.60	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.24	0.70	-5.08	5	14	2009-09-10 21:41:12	2008-09-08 14:01:14	3	3	10	0	9	15	0	190.90	37	28.88	CHANGED	DDDDDETDC--..ET.............llPTsosslTTlsGoGuVTlTsGGSGu..sshttou..........oILPTtoup.......DDDD..sD--TDsEssT.sh.ssGoVTpsPTGoTotTllsoc...uTTssDDDDssssEooIs..DsTssTssT.hTssGsPTs.TVTTNusATTTs+Tpscss.....lTYTuTGpspTTtsTp--ED...CDEThshThThhsPoTTVh.sstlhsNsVTVIupho.h.pshEsDutpssGSGSGSsGSGGS..GSGSS	..........................................s.h.s..s....h.h.sss...hssssto...........s.lsThssp..................ssD-...D-ETDCETsh.sh.PsGss........ThhsTsosohTllsTc...sTTos----psssEssh...psTs.sp.T.hT.sts.TT..lssphssssp.....chs.....lTYTusGpshTThhoppsE....C-EThhhThThhsPpTTVh.sstl.sssVTllsp.o.h.ps.psDsh.......pGpssuuuS..uSGuS.......	0	3	5	9
+11429	PF11597	Med13_N		Mediator complex subunit 13 N-terminal	Coggill P	anon	manual	Domain	Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood [4].	25.00	25.00	34.70	33.50	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.33	0.70	-5.79	18	237	2009-01-15 18:05:59	2008-09-09 14:16:19	3	6	144	0	154	218	0	328.70	28	18.84	CHANGED	Ms..st.......................sthoNhhsl........sthssIha+ha..............s...s.hhp.hp+h.phc.LplhhRp.ss...................................tthtLWlF.hssp.p.ht...............ptts.pstlshpstoLhhpA.tsl.tpsLhcs.hsphspttsss.sssp+s......ssssp+........................................hushashFlousosslot.hl+ppssI.LsoRohlshspp..........................................................phh.sPhslssshou.sh..Los........................................................................................................................................................hpsplsusGcLsVuhpshshPulhsLss.s-sst.h..h..tsslhhuPouuhuphhusssssssssssssssssttsssps...............sshpphphtshphLpthGhs.sss.pspsWlplpshpshhsplssphhptsppsppss....shchlhWPtphCF	.......................................................................................................................................splsuIpW+ha....t...................s..s..tsshh.u.h.cshps.phltshhRp.t........................................st+pLWlF....ah..s.p.-..ssh.t.ht.................pp..s.hp.st..lsh...ps.p.oL.lhcA.hts.lhp...+.s.Lhpc.shs+hGcahl..pP.hp..psc+.......hspSp+..................................................LSsuFsFFlHG-SsVCoSl-lppHpslhLlscpHlph..Apps............................................................tshpVhluPaGls.GsLTGpuh.chos....phhtc....................................................................................................................................................p....hc..ss..ssVcVlVu....u.s+hhaPuthlLl....stsD.s....................ssssuth.......u....t...h...s..spps..sus.psss.ps....s...hssss.s.t......................................p..ptpth.ph.s........t....tt...p...t.ts.....thh.hsht.C........................................................................................................	0	30	56	106
+11430	PF11598	COMP		Cartilage oligomeric matrix protein	Pollington J	anon	pdb_1fbm	Family	This family of proteins represents the five-stranded coiled-coil domain of cartilage oligomeric matrix protein (COMP). This region has a binding site between two internal rings formed by Leu37 and Thr40 [1]	20.80	20.80	20.90	21.10	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.27	0.72	-3.89	12	203	2009-01-15 18:05:59	2008-09-09 14:26:53	3	22	60	15	94	168	0	44.50	45	5.26	CHANGED	DhscpLl...spLpphsplltEL+-.l+p.......................Ql+EhshLRsTItcCpuCG	...........spthl...pplpphNplLsEl+-hlRp..................................................QVKEhoaLRNTIhECpuCG...	0	10	19	44
+11431	PF11599	AviRa		RRNA methyltransferase AviRa	Pollington J	anon	pdb_1o9g	Family	This family of proteins represents the methyltransferase AviRa from Streptomyces viridochromogenes. This protein mediates the resistance to the antibiotic avilamycin. AviRa methylates a specific guanine base within the peptidyl-transferase loop of the 23S ribosomal RNA [1].	26.10	26.10	26.60	132.50	24.60	26.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.73	0.70	-5.35	2	11	2012-10-10 17:06:42	2008-09-09 14:39:40	3	1	11	2	6	13	1	242.50	39	98.23	CHANGED	Mp.Y+a.scp.s.pDhAsGhVLapssG.PsFPVRLAhEIapRsLth..tcu.loLaDsCCGuuYhLolLGLL+ppoltplhuSDlsstslpLAscNLuLLo.uGlstRc.Eh+t..ppatKsSal-AhpuhcRlcEhLTtE.......I+Th.lFcspsLpss.hs.sPDlllTDlPYGphscWEt..sutslsthhpuLuushsucslIsV.hD+ppKI.ss.hptLER.hlGpRph.lh..+Au-lh	....p.Y+atosptsYpDhASG+VLasAsGhPuFPVRLASElhQRshphL.p...p...uPhTLaDPCCGuGYLLTVlGLLHscplpplluSDlsscsLplAt+NLuLLotpGLppRpcpL+chhcpasKPSah-AlcSAcRLcchlsts.ss.s.tshtpADlhcsps.tsh.stshss.cIVlTDLPYG-hosWpG...suss...PlsphLsultslL.P.spuVVsV.os+ucKlp.p.sch+tlc+lKlG+Rpssla..h.........	0	2	6	6
+11432	PF11600	CAF-1_p150		Chromatin assembly factor 1 complex p150 subunit, N-terminal	Pollington J	anon	pdb_1s4z	Family	CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesised and acetylated histones H3/H4 into chromatin during DNA replication and repair [1]. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesised and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis [2].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.26	0.70	-4.96	13	305	2012-10-03 14:45:15	2008-09-09 14:49:06	3	48	200	0	206	304	4	187.60	19	26.44	CHANGED	ssEucshEsss-s-.SVLSpSSh.SShSso.SSPEussss.chpss..........sSPhsuSTslc+hopKpl+pptEKpKh+hp+....ttth..............hctE+pE+ccl+...pEtKtttc+tK......EEt++cKcEEK-l+E+ER..+E..KKE+-EKEKAEK.RlKEE+RKE+p..Es.t.....AKhEEKRK....KEEEKRL+EEc.......cRIKAE..KAEITRFFQKPK.TspAPK.........TLAuuCGKFAPFEIKEsMlL	..........................................................................................................ts........................................................t...............................ps.....ps.....hp.p.h..p..pp.hp...t.t..t...cp.p..p..p...pc............t.tt.........................pp.pc+p.c.c.c.ct+..ccp..+p.p.c....c....p..pK.......cpcccc..+.c.c....c+.c...tcc....cE.+......cc.....c+p..ccE.c-+..tc.....+pc.....+cccc.cc.cp...............t+..cp.cpt.......+ccp....cphtpct.............................ptp.....t.....h.t.h....................................................................................................................................................	0	66	109	166
+11433	PF11601	Shal-type		Shal-type voltage-gated potassium channels 	Pollington J	anon	pdb_1s6c	Family	This family of proteins represents Shal-type voltage-gated potassium channels which interact with Kv channel-interacting proteins to modulate cell surface expression and function of Kv4 channels. The interaction of the Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs [1].	20.50	20.50	22.60	22.10	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.43	0.72	-4.43	4	194	2009-01-15 18:05:59	2008-09-09 15:44:02	3	6	79	11	112	179	0	29.00	79	5.01	CHANGED	uuVAAWLPFARAAAIGWhPlAspPLP..P	...AGVAAW.LPFARAAAIGWhPlAssPMP.AP...	0	19	28	59
+11434	PF11602	NTPase_P4		ATPase P4 of dsRNA bacteriophage phi-12	Pollington J	anon	pdb_1w44	Family	P4 is a packaging motor which is involved in the packaging of phi-12 genome into preformed capsids using ATP. P4 is located at the vertices of the icosahedral capsid. ATP drives RNA translocation through cooperative conformational changes [1].	20.40	20.40	20.90	28.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.02	0.70	-5.44	3	7	2009-01-15 18:05:59	2008-09-09 16:09:10	3	1	5	60	0	10	1	299.70	30	90.31	CHANGED	s+LhDAKPsAl.+lApPAAlcTsussoah...AAVhE.Sl+DGGs.......LhAVGlc...PlVlDKDAtphlAsKtKSuDsESs..........uVshVsVpNssl+..........osPLLus+PVsu..usHRWsscshhSGlslVsGuTGSGKS.......csLNuK.cPDVTIRWGEPuEuYDp.DouVaVuDLsEMLhVslhLAsLsaRV.VIDSlRNLlFulsGAAouGGISsuhYuLLTDIuNlsAphGClVVAulNPMSsDDK.VELVassltASosGhllssDussVSQTlhRTGcGRIFsG.tPLsRsTHslphccPcHopLs-HTShuSsu+LESG....oVDsDDEN-SsPRRGA	..........................................................................................c.hDApshuh.hhut.sshpsss.ts.....uuVhc.u.cpGs........lhuls.......Vh.Kss..hht.t.huscs.ss..............V...sshhh..........ss.hluppPVs.....HRas.....SGlhslhGtssSGKo........tLstc.cs.shIRaGEshpuYsp.Dhsltlsslsc...sslhLu.shsapV.slDSlRsllhpltGsAouGGIstshauhLTDluslhsphsC.VVhslNPhsss-K....lE.hVatpshASssuhhlssDss...pshhRTscGhIhsu.tsLstssc..phphspphphh.+oo.susu.ltps....oV.ssDc..shsRRhs..................	0	0	0	0
+11435	PF11603	Sir1		Regulatory protein Sir1	Pollington J	anon	pdb_1z1a	Family	Sir1p interacts with the BAH domain of the Orc1p subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae [1]. The amino acids from the ORC interaction region of Sir1p are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing [1].	25.00	25.00	25.70	25.10	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.64	0.71	-3.99	2	55	2009-01-15 18:05:59	2008-09-09 16:23:57	3	3	21	4	21	61	0	126.40	31	27.48	CHANGED	h.p....lssRhhVhDGaLlDhsccKPIN.+sPclhhLL.pDcphthlsQ.NLVcWschKK.pss..lslKuhpLFKahK.lh+cFhhhtDh+lhhh.hcupL+Yc.sc+hT..CpCs.l.Lsc.ss.Ylas.	......hh........lSsRasVl.DGaLlDhsc......+Ks.IN.c...sPclhp....hL.sDc-tcplsphsLlDWschK...c.s...pss..lslcuppLFchlcthh+cFhpstD.G+l..hlhsscsph+hc..scchT..p+Ch.lhLschsshYla................................	0	2	12	19
+11436	PF11604	CusF_Ec		Copper binding periplasmic protein CusF	Pollington J	anon	pdb_1zeq	Family	CusF is a periplasmic protein involved in copper and silver resistance in Escherichia coil. CusF forms a five-stranded beta-barrel OB fold. Cu(I) binds to H36, M47 and M49 which are conserved residues in the protein [1].	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.30	0.72	-4.12	186	1350	2009-01-15 18:05:59	2008-09-09 16:47:19	3	19	804	6	364	993	141	68.20	33	32.48	CHANGED	Gplppl-.tssplTlpHuslss..lsh.P.uMTMsFs.ls...sss..lsslpsGspVcFphpp.ssss.hs..lsplp..p	.......GhVcslDhpspplTlpHsPIss.........ls...W..P.uMTM.sFs.ls...sss..thsplKsG-cVpFshhp.psst.hh..lpslp...s.............................	0	72	191	266
+11437	PF11605	Vps36_ESCRT-II		Vacuolar protein sorting protein 36 Vps36	Pollington J	anon	pdb_2cay	Family	Vps36 is a subunit of ESCRT-II, a protein involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late endosomes [1].	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.79	0.72	-4.17	22	246	2012-10-04 00:02:25	2008-09-09 17:02:47	3	7	224	4	174	261	0	86.50	33	17.27	CHANGED	phssSspPlLppsEp.lhlpcsVGLYpGcp..KhhsppsG+laLTo+RlIYsDstcspp.ulsltLphlpps....chsuuFh.ppSsKIhlhLcp	..................t.hpshL....sEshlhhp..csVsL.Y...-Gct..........Kh.............p.........apsGplhLToHRllah.Dpp.p...s....p..p.........s..lulsLppltph.........Eht.uuhl..tpSsKIhlalc...............................	0	52	88	142
+11438	PF11606	AlcCBM31		Family 31 carbohydrate binding protein	Pollington J	anon	pdb_2cov	Family	This family of proteins represents the family 31 carbohydrate-binding module of beta-1,2-xylanase. This protein is from Alcaligenes sp. strain XY-234. The AlcCBM31 module makes a beta-sandwich structure with an immunoglobulin fold and contains two intra-molecular disulfide bonds. AlcCBM31 shows affinity with only beta-1,3-xylan [1].	25.00	25.00	35.20	108.70	19.20	16.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.18	0.72	-4.02	3	5	2009-01-15 18:05:59	2008-09-10 10:58:01	3	2	3	6	0	6	0	92.00	48	19.81	CHANGED	EPPENCoDDFNFNYVSDsEIEVYHVDK.GWSAGWNYLCLDDYCLSGTKSNGAFoRoFSAsLGQTYKlTFKVEDhsGQGQQIlD+slTFTsQVCN	...psPEsCo-DFGaNYVSDoEIEVFHpDp.GWSAGWNYlCLDDYCLsGsKSNGuFsRoFsAsLGQTYKITFKVED..GpGQaIlDKslTFTNpsCs.	0	0	0	0
+11439	PF11607	DUF3247		Protein of unknown function (DUF3247)	Pollington JE	anon	pdb_2e12	Family	This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions [1].	25.00	25.00	66.70	66.40	21.00	20.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.17	0.72	-3.77	7	26	2009-09-10 23:21:42	2008-09-10 13:05:27	3	1	26	2	6	28	0	98.30	64	94.18	CHANGED	MPKYAPHVYoEQsQIATLEtWVsLLDGQERVRIELDDGSMIuGTVAVRPolQTYhDEpccEGsNGQLRLDpLDASQEPQWIWMDRIVAVHPhPLGA.PpVMP	...MsKaAP+VYoEQsQIATLEpWVsLLDGQERVRIELDDGSMIuGTVAVRPolQTYhD-pcsEGlNGQLRLDpLDASQEPQWIWMDRIVAVHPL.LGAsPpVMP......	0	1	3	4
+11440	PF11608	Limkain-b1		Limkain b1	Pollington J	anon	pdb_2diu	Family	This family of proteins represents Limkain b1, which is a novel human autoantigen, localised to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.92	0.72	-4.23	5	78	2012-10-02 20:46:34	2008-09-10 13:06:52	3	15	49	1	42	105	2	86.10	62	6.32	CHANGED	CpSLLaVaNLPsN+D...uKAIuNRLRRLSDNCGGKVLuISGsSAlLRFuNQEuAERApKRMENEDVFGNRIoVSaoPt.R-ss-scschp.ss	.........................CHTLLYVYNLPsN+D...uKSlSNRLRRL....SDN.C..GG.KV.L.....S....I......o...G..s.S...AILRFlNQ-SAERAQKRMENEDVFGNRIhVSF.o.P+s+Ehs-scsp....shs............	1	12	14	25
+11441	PF11609	DUF3248		Protein of unknown function (DUF3248)	Pollington JE	anon	pdb_2e6x	Family	This family of proteins is thought to be the product of the gene TT1592 from Thermus thermophilus however this cannot be confirmed. Currently there is no known function.	20.20	20.20	20.20	73.70	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.83	0.72	-4.27	2	19	2009-01-15 18:05:59	2008-09-10 13:13:55	3	1	19	4	13	17	0	63.20	63	84.51	CHANGED	L-tLGtpLVWRhG+sE.pDslVVRlGhASATPRFtcLPRLhshs-AEhpchsQpGRlhlEWV-	L-tLGpHLVWRIG+uEsE-l...LVVRVGLASATPRFtcLPRLhNlsDAElccLlpcGRVRVEWVE.	0	3	8	13
+11442	PF11610	Ste5		Scaffold protein Ste5-Fus5 binding region	Pollington J	anon	pdb_2f49	Family	This family of proteins represents the Fus5 binding region of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mitogen-activated protein kinase. Auto-activated Fus3 has a negative regulatory role, and promotes Ste5 phosphorylation which leads to a decrease in pathway transcriptional output [1].	20.60	20.60	21.60	68.50	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.31	0.72	-4.42	2	10	2009-01-15 18:05:59	2008-09-10 13:47:16	3	1	9	0	1	10	0	30.00	98	3.34	CHANGED	TPVERQTIYSQAPSLNPNLILAAPPKERNQ	TPVERQTIYSQAPSLNPNLILAAPPKERNQ	0	1	1	1
+11443	PF11611	DUF4352	TRF2;	Domain of unknown function (DUF4352)	Pollington J	anon	pdb_3cfu	Family	Members of these family are poutative lipoproteins that fall into the Antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.52	0.71	-3.98	49	1093	2012-10-03 03:07:29	2008-09-10 15:00:56	3	22	747	2	203	850	26	123.50	19	50.75	CHANGED	hplu-ssp.h.sshplsVsss.....ths.s.sphhp............pssspalllslolcN.puccshshss..pFpLh.cspupphc.hshsspptt......s................h.hsslsPGppssGplsFclspssp....hpLpa.....ssh.asst......tl	...............................................................spssp.......s.s.h.cl.....olsss..........hs.s.sp..h.t..ps.....................pstspa...lhls..lsl.....c.N...puccsl..s...h....s...s...t...pa.pLh....s...sc.sp...p...a..c...hs.ssst.t......t................hhhpplsPspshpG.p.......l.sF.-l..sp...ssp.....hplph....ssh.......t..................................................................	0	69	147	184
+11444	PF11612	T2SJ	GspJ;	Type II secretion system (T2SS), protein J	Pollington J, Desvaux M	anon	pdb_3ci0	Family	The T2SJ proteins are pseudopilins, which are targeted to the membrane in E. Coli. T2SJ forms a complex with T2SI (Pfam:PF02501) and T2SK (Pfam:PF03934) which is part of the Type II secretion apparatus involved in the translocation of proteins across the outer membrane in E.coli. The T2SK-I-J complex has quasihelical characteristics [1].	20.40	20.40	20.40	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-11.27	0.71	-4.52	87	934	2009-09-11 07:38:19	2008-09-10 16:15:32	3	4	804	11	192	656	242	157.00	26	74.61	CHANGED	c-tspppspclppLQRuhshl-pDlpQh..................................ss....RssRst...Gt..sshhhtssp.................ltFsRsGWtNP.th............PRusLp+VsY..pl............p........ssp..LpRhhashhDs.stst.tPthp...slLss.........Vpshplca..h..........sss..............pWpcp...Wss.............sptLPpulclplphpsh....G.plpRhahlssts	..............................................................................................p..hsttcspclstlQpshshlppDlpQh..................................hs............R.sRss....ut..sthh.htss...h...t...............hltFsRtuhhNP..h..............sRusL.p.VsYcl.................c......................ssp.......Lp.R.hsa.s..hsDs....sss....pPthp............sLlst..................Vcuhplpa.....a.................................sss.........................pWppp.....Wss...........................sptlPh.AVclsLphpph....G.plpRhahl.t.s................................................	1	54	108	151
+11445	PF11613	UCN2		Agonist of corticotropin releasing factor R2, Urocortin-2	Pollington J	anon	pdb_2rmg	Family	This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif [1].	22.00	22.00	40.90	40.50	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.74	0.72	-4.00	4	62	2009-01-15 18:05:59	2008-09-10 16:49:57	3	1	35	5	36	68	0	37.80	66	26.12	CHANGED	lsLSLDVPhslhplLh-.A+AKshRsQAAsNA+lLA+l	hTLSLDVPTNIMNILFslAKAKNlRApAAANA+LhAQI.	0	2	3	10
+11446	PF11614	FixG_C	Bre5;	IG-like fold at C-terminal of FixG, putative oxidoreductase	Pollington J, Coggill P	anon	pdb_2r39	Domain	This domain is part of a transmembrane protein, FixG, itself part of the FixGHIS operon closely associated with the FixNOPQ operon that is the symbiotically essential cbb3-type haem-copper oxidase complex. FixG expression is induced by oxygen-deprivation. This C-terminal domain adopts an E-set Ig-like fold.	25.60	25.60	25.60	25.90	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.69	0.71	-3.99	345	1156	2012-10-03 16:25:20	2008-09-11 09:45:12	3	18	966	1	346	998	117	120.90	25	25.60	CHANGED	hlhslspRsslclsVl+DRssLah.phscGp....IcNsYsl+lhNpsppspp.aplslp...G.............shpl...............s...........pplplsssps......tphslhlps..sspt...........ht...pssp.slphpl....p........t........s.stthp.sp.....pcopFhsP	.............................hhhslspRpshtlsVl+DRs.hhh..pp..ssGp....IcNsYsl+lhNpsppspp.aplslp..G..hs............slpl.............................t.....sppslpl.tsuchhplsVhlps..s.pt............hp...pssp...slphplp.......p.....s.ssphs.hp......pcopFlsP...................................	0	95	216	281
+11447	PF11615	DUF3249		Protein of unknown function (DUF3249)	Pollington J	anon	pdb_2pqr	Family	This family of proteins represents the gene product of the protein CAF4, the yeast protein YKR036c. This protein contains seven WD40 repeats in its C terminus. The function however is unknown [1].	20.70	20.70	20.70	151.10	19.50	17.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-8.99	0.72	-4.23	2	13	2009-09-13 21:11:59	2008-09-11 10:25:08	3	1	13	2	4	10	0	60.00	100	9.25	CHANGED	QKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQR	QKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQR	1	1	1	1
+11448	PF11616	EZH2_WD-Binding		WD repeat binding protein EZH2	Pollington J	anon	pdb_2qxv	Family	This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression [1]. This interaction is required for the HMTase activity of PCR2 [1].	25.00	25.00	32.00	30.80	18.50	17.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.14	0.72	-7.19	0.72	-4.08	6	144	2009-01-15 18:05:59	2008-09-11 10:59:13	3	3	38	1	55	146	0	29.80	68	4.73	CHANGED	KuhFsSNRQKI.E+T-ILNpEWKphRIQPl	...KoMFsoNRQKIhERT-ILNQEWKpRRIQPV.	0	2	6	21
+11449	PF11617	Cu-binding_MopE		Protein metal binding site	Pollington J	anon	pdb_2vov	Family	This family of proteins represents a unique protein copper binding site that involves a tryptophan metabolite, kynurenine in the protein MopE. The production of kyneurenin by modification of tryptophan and its involvement in copper binding is an innate property of MopE [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.57	0.72	-4.17	36	222	2009-01-15 18:05:59	2008-09-11 11:40:36	3	34	44	0	161	228	684	29.10	42	8.14	CHANGED	DCsDsssslpPGA..sElC.DulDNsCDGtsD-s	...........DCsD...tsstlhPuA....sE....lC.s..G.l.DssCsGthDp.......	0	78	87	128
+11450	PF11618	DUF3250		Protein of unknown function (DUF3250)	Pollinton J	anon	pdb_2yrb	Family	This family of proteins represents a protein with unknown function. It may be the C2 domain from KIAA1005 however this cannot be confirmed.	27.70	27.70	28.70	36.30	27.60	27.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.27	0.72	-3.85	11	173	2009-01-15 18:05:59	2008-09-11 13:07:17	3	8	74	1	82	129	0	107.00	44	9.07	CHANGED	TFCThsFaDFETpoTPlspGhpshYsFTopYsVphDsLhlpYLposulhl-LHpsh.upE..acTlAuutlshctll.....-psu.+ltuosshsususp..shGsl-Yhh+lphP	.............TFCTYuFYDFEhpsTPllp.G.pPtY.sFTSQYlVcscsLFLpYlQ...............psol.pLElHQAh..us-...acTlAAsplphcclL...................Epss........+.lauos...sL..s.Gsp......G-.....saGslEYWhRL+hP....................................	0	23	31	51
+11451	PF11619	P53_C		Transcription factor P53 - C terminal domain	Pollington J	anon	pdb_2rp4	Family	This family of proteins is the C terminal domain of the transcription factor P53. While the rest of the protein is quite conserved between the different transcription factors such as p53 and p73, the C terminal domain is highly divergent. The DM-p53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix [1].	25.00	25.00	56.50	55.20	21.80	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.46	0.72	-4.23	2	16	2009-09-11 05:01:43	2008-09-11 13:16:24	3	1	12	4	7	17	0	70.20	66	16.58	CHANGED	DDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHANKLLSLKKRAYELP	........A-WsVSRT.DGDYRLuITCPpKEWLLQSIEGMIKEAAAEVLRNPNp.-NLR+HAN+LLSLKKpAaELP......	0	1	1	4
+11452	PF11620	GABP-alpha		GA-binding protein alpha chain	Pollington J	anon	pdb_2juo	Family	This family of proteins represents the transcription factor GABP alpha. This alpha domain is a five-stranded beta-sheet crossed by a distorted helix termed an OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300, a direct link between GABP and transcriptional machinery has been made [1].	21.90	21.90	21.90	34.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.92	0.72	-4.00	5	88	2009-01-15 18:05:59	2008-09-11 13:47:53	3	5	69	1	55	81	0	86.80	60	19.93	CHANGED	s--lIVQcIDI+EPIusLKKLLEsRLplS.LctY-IaLQDhQ.L-PD+SLFDQGVKs-GoVQLSVQVQTt.s.ccKLNIlEIVKPs--Vcs	.......s.s-hlsQsIDINEPlGNLKKLLEPRLQsS.LDua-ICLQDIQ.L-P-+SLFDQGVKTDGoVQLSVQlh.oht.................G..-.KLNILEIVKPsEsVc.......	0	14	18	35
+11453	PF11621	Sbi-IV		C3 binding domain 4 of IgG-bind protein SBI	Pollington J	anon	pdb_2jvg	Family	This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation [1]. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold [1].	25.00	25.00	34.20	34.10	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.36	0.72	-3.82	2	163	2009-01-15 18:05:59	2008-09-11 14:00:45	3	2	160	4	2	45	0	68.00	96	16.01	CHANGED	VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVpcHLQKQLDALVAQKDAEKKVA	...........VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA..	0	1	1	2
+11454	PF11622	DUF3251		Protein of unknown function (DUF3251)	Pollington JE	anon	pdb_2jwy	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. Some members if this family are annotated as putative lipoprotein YajI however this cannot be confirmed.	19.90	19.90	20.00	22.50	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.77	0.71	-4.84	7	846	2009-01-15 18:05:59	2008-09-11 14:18:11	3	1	485	1	36	261	2	165.70	41	85.84	CHANGED	CA.QpEl.ph+pslSpLNQchTpLsppssKlpQQNtLNAcSspGVYLLPuApTsuRL-SplGpLphSLtsIpstAsGopssL+Ips.SscsLPAFsApVEaGQlpuTotshtpsssQsQ.hsAPsSlLssS-ssIsLpLsGloP-QLGFlRlHslQP......lsp	.............................................................................................Qh+ppluTLppphTp.......lpppTspI...Tpps+.L......s......tcppps.la....L.P...utpp.hhLp.upIGsLthpllsIsPsssGoslpLcl.s..ssPls.shuhsspaGphpsTpsph.th.hQ...spL...h....N....ushplLsso.sDIsLpLKGlSPspLGal+Ip................shp....................................	1	1	6	20
+11455	PF11623	DUF3252		Protein of unknown function (DUF3252)	Pollington J	anon	pdb_2jz2	Family	This family of proteins has no known function. Some members are annotated as Ssl0352 however this cannot be confirmed. Currently there is no known function.	20.80	20.80	21.10	69.80	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.56	0.72	-4.56	16	94	2009-01-15 18:05:59	2008-09-11 14:25:39	3	1	88	3	43	88	112	52.90	62	50.51	CHANGED	hILPGssV+VpNssshYatapGhVQRloDGKAAVLFEGGNWDKLlTFpLsELE	...ILPGssVpVpNssssYatYpGhVQRloDGKAAVLFEG.GNWDKLlTFcLsELE.	0	7	28	39
+11456	PF11624	M157		MHC class I-like protein M157	Pollington J	anon	pdb_2nyk	Family	This family of proteins represents M157,a divergent form of MHC class I-like proteins which is the protein product of the mouse cytomegalovirus. This protein is unique in its ability to engage both activating (Ly49H) and inhibitory (Ly49I) natural killer cell receptors. M157 is involved in intra- and intermolecular interacts within and between its domains to form a compact MHC-like molecule [1].	20.60	20.60	21.10	21.20	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.79	0.70	-5.27	5	132	2009-01-15 18:05:59	2008-09-11 14:50:58	3	1	6	1	0	116	0	237.50	23	63.71	CHANGED	TVTRoGaHKRTISVsNGRPVVVWDsGDKNPKICKICPAVoSINsEYlFLDIQKMRLsNLLuQuLh-sQRICVRYsCLFL..+FDV.......lCDVYHTTD+VRlTYp+QTsKINIQGSGTFshSDAKshGlaMLpsNVcEIKp+WRsTVQpLKQLGYMNcTEVEFWYNT...TGLTTCVVTSRSNsPFTVELSLNTNSSAIVT.....EESTVDsQsVTVKAPGSasQRCYVTSSLGWKGVVT..PPSQYRTK......RsPVN.ISSSKhTGI	.........................................................................................h.......................................s.so-h...ssEhhFhtpQppaLpp.hhphl.tt.stt.........l.slcYpCpah....hhsh........tCpV..hhsss....psp..l.....hhh...........hs....sp.t..s.......ss..ps..........s.s........s...............h........s....s......scuhulphLpspsppIppRWpssspclhphup.scs-hpFhhsh......pGhspCslpSpuslhaplpl...s..s...s..s..s....s..tshss........shssh..hps.ss....sps.s.s..s..t....s....tChlpSohG.Wpsslp.........................................t.............................	1	0	0	0
+11457	PF11625	DUF3253		Protein of unknown function (DUF3253)	Pollington J	anon	pdb_2ns0	Family	This bacterial family of proteins has no known function.	20.60	20.60	21.10	22.00	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.83	0.72	-4.10	28	140	2009-01-15 18:05:59	2008-09-11 14:57:13	3	4	137	1	72	146	38	83.60	37	82.99	CHANGED	hsssspplctsILcLlupRusspolCPSElARAl.......us-s..WRthMssVRpsAtcLsptGclplppKGc....sV.DPssh.+GPlRlth..ts	...............................................h....ttplctsIlpLlspRus....spolCPSElARAl......................................us-s....WRsLMtslRcsAhcLspsGclpIhQ+Gc......sV...DPssh....RGslRlph...tt.........	0	26	49	61
+11458	PF11626	Rap1_C	Rap1_C; TRF2IP; Yippee-Rap1;	TRF2-interacting telomeric protein/Rap1 - C terminal domain	Pollington J	anon	pdb_3cz6	Family	This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres [1]. The Rap-1 C terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C terminal domain [1]. Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends from attack by DNA-repair mechanisms [2,3,4,5].	20.10	20.10	20.10	20.20	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.93	0.72	-4.10	81	175	2012-10-03 10:46:08	2008-09-11 15:24:49	3	12	150	7	118	164	1	88.60	26	15.59	CHANGED	lpp.hpphGh...spphls.pALtsoot-hthstp.llph.........hpt......sps.....................P.....sh.GlWTpcDDphLpss...................................sspshcp.............LhpKH...G.ppplptRhcFLpt	..............................................h....hpphsh...ststls.pALhpsSu-hthssphlhsh.................hpt..........sps.................................h..........P..sh.GlWTccDDpsLpts...................................-pcshcp.............LlcK+...G.spplptRhcFlp.t................................	0	25	52	88
+11459	PF11627	HnRNPA1		Nuclear factor hnRNPA1	Pollington J	anon	pdb_2h4m	Family	This family of proteins represents hnRNPA1, a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins are involved in numerous RNA-related activities [1].	25.00	25.00	25.00	25.00	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.23	0.72	-3.79	8	294	2009-01-15 18:05:59	2008-09-11 16:01:28	3	6	38	0	124	141	0	36.70	76	13.49	CHANGED	GssYNDFGNYsuQ.pSNYGPMKuGsaGGh.R..sSG.PYGGG	............GGuY.N.....DFG.N.YNN....Q.SSNFGPMKG.GN.FGG..R......SSG.PYGGG.............	0	1	3	7
+11460	PF11628	TCR_zetazeta		T-cell surface glycoprotein CD3 zeta chain	Pollington J	anon	pdb_2hac	Family	The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues [1]. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerisation and assembly with TCR [1].	25.00	25.00	30.20	42.30	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.46	0.72	-4.49	43	108	2009-01-15 18:05:59	2008-09-11 16:17:06	3	4	42	2	36	124	0	32.80	62	22.10	CHANGED	DPKLCYlLDGILFlYGlIlTuLaLRhKFp+uts	.DP+LCYlLDGILFlYGlIlTALalRhKhpcut....	0	2	4	7
+11461	PF11629	Mst1_SARAH		C terminal SARAH domain of Mst1	Pollington J	anon	pdb_2jo8	Family	This family of proteins represents the C terminal SARAH domain of Mst1. SARAH controls apoptosis and cell cycle arrest via the Ras, RASSF, MST pathway. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process [1].	22.70	22.70	22.70	35.10	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.58	0.72	-4.14	11	152	2009-01-15 18:05:59	2008-09-11 16:32:35	3	4	93	2	86	143	0	48.80	64	9.94	CHANGED	-a-FLKshoh-ELppRLtSLDspMEpEIEEl+pRYpuKRQPILDAI-AK	....Da-FLKsholE-LQpRLtuLDPMMEpEIEElRQ+YpuKRQPILDAh-AK..	0	25	30	54
+11462	PF11630	DUF3254		Protein of unknown function (DUF3254)	Pollington J	anon	pdb_2job	Family	This family of proteins is most likely a family of anti-lipopolysaccharide factor proteins however this cannot be confirmed.	25.00	25.00	26.50	45.80	21.50	17.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.16	0.72	-4.04	10	69	2009-01-15 18:05:59	2008-09-11 16:40:43	3	1	21	1	0	84	0	94.50	46	83.19	CHANGED	CpAQuhpsL.lsullsKlssL..Wcsucl-hLGHpCpapVcPsl++acLYa+G+MWCPGWT...sIpGEu+TRSRSGslp+ul+DFVpKAhppGLITEE-ApsWLs	..............CpAQ.apsl.suulssK.ls.sL..W+ssps-hLGHpCpashpPplKRapLYa+G+hWCPGWT...sIcGc.upT.RS+S.Gsstcss+DFVpKAhppGLITpp-Ap.WLp.	0	0	0	0
+11463	PF11631	DUF3255		Protein of unknown function (DUF3255)	Pollington J	anon	pdb_2joz	Family	Members in this family of proteins are annotated as YxeF however no function is currently known. The family appears to be restricted to Bacillus.	25.00	25.00	32.10	223.80	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.64	0.71	-4.50	2	18	2009-01-15 18:05:59	2008-09-11 16:44:32	3	1	18	1	3	17	0	121.40	77	86.84	CHANGED	lMloGCpQpK.-EsPFYYGTWDtGhtPGPhDGV+StTVTFTcDpVlpppVhpGRGEVthP..sYKVISQsTDGoIEIpYLG..aPlKSTLKRGcNsTLIWc..GppKTMTRI..KTGtE-tcEK	lMloGCQQpK.-ETPFYYGTWDtGLpPGPMDGV+StTVTFTKDcVlpppVIcGRGEVphP..AYKVISQsTDGoIEIpYLG..aPlKSTLKRGcNsTLIWc..GpTKTMTRI..KTGtE-tcEK..	0	1	1	1
+11464	PF11632	LcnG-beta		Lactococcin G-beta	Pollington J	anon	pdb_2jpk	Family	This family of proteins is LcnG-beta, which with LcnG-alpha constitute the two-peptide bacteriocin lactococcin G (LcnG). This family of proteins represents the N terminal domain which has an alpha-helical structure and is amphiphilic. Both peptides have a GxxxG motif which they use for interaction through a helix-helix structure [1].	19.90	19.90	78.50	78.00	18.90	17.00	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.68	0.72	-4.21	2	5	2009-01-15 18:05:59	2008-09-11 16:57:19	3	1	3	2	0	5	0	35.00	70	63.87	CHANGED	t.htWLsWlpPAh-FlpGhuKGhhKEGNKsKWKNl	KKWGWLAWV-PAYEFlKGFGKGAIKEGNKDKWKNI	0	0	0	0
+11465	PF11633	SUD-M	Nsp3;	Single-stranded poly(A) binding domain	Pollington J	anon	pdb_2jwi	Domain	This family of proteins represents Nsp3c, the product of ORF1a in group 2 coronavirus. The domain exhibits a macrodomain fold containing the nsp3 residues 528 to 648, with a flexibly extended N-terminal tail from residues 513 to 527 and a C-terminal flexible tail of residues 649 to 651. SUD-M(527-651) binds single-stranded poly(A); the contact area with this RNA on the protein surface, and the electrophoretic mobility shift assays confirm that SUD-M has higher affinity for purine bases than for pyrimidine bases.	22.40	22.40	23.10	83.20	21.70	22.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.65	0.71	-4.91	6	195	2009-01-15 18:05:59	2008-09-15 09:39:56	3	10	84	11	0	175	1	142.70	83	2.41	CHANGED	ssp.lhss.ussssssllsslshuapuMlpauKcpGhLhPlshDYsAhsKlLKR....hcspEGlhTs-GhcFYhYSpccPLp-V.pALNuhs+sllhhPFGalspGhsLA.SAssMRsLTVPasVllsScssVPlYpuYhsus	.........S.AFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDY.GVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTY.NGYLTSS..	0	0	0	0
+11466	PF11634	IPI_T4		Nuclease inhibitor from bacteriophage T4	Pollington J	anon	pdb_2jub	Family	This family of proteins represents IPI from bacteriophage T4. This protein is a nuclease inhibitor which is injected by T4 to protect its DNA from gmrS/gmrD CT of pathogenic Escherichia coli into the infected host [1]. The structure of this protein consists of two small beta-sheets flanked by N and C termini by alpha-helices. The protein has a gmrS/gmrD hydrophobic binding site [1].	25.00	25.00	25.30	93.50	23.90	18.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.57	0.72	-4.10	2	6	2009-09-11 14:10:27	2008-09-15 09:51:27	3	1	5	1	0	5	0	75.70	85	79.37	CHANGED	ATLTSEVIKANKGREGKPMISLVDGEElKGTVYLGDGWSAKKDGATIVISPAEETALFKAKHISsApLKIIAKsLL	ATLTSEVIKANKGREGKPMISLVDGEEIKGTVYLGDGWSAKKDGATIVISPAEETALFKAKHISAAHLKIIAKNLL	0	0	0	0
+11467	PF11635	Med16		Mediator complex subunit 16	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function.\	  Med16 is one of the subunits of the Tail portion of the Mediator complex and is required for lipopolysaccharide gene-expression [4]. Several members including the human protein, Swiss:Q9Y2X0, have one or more WD40 domains on them, Pfam:PF00400.	25.00	25.00	25.60	25.10	22.40	24.80	hmmbuild  -o /dev/null HMM SEED	753	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-13.32	0.70	-6.57	18	264	2009-01-15 18:05:59	2008-09-15 10:38:09	3	7	176	0	170	275	0	534.40	21	81.27	CHANGED	pphts..scsssssIluhpWLssp+.slhhpptshhs........................tt.sssshappplp.h.PhGshHPsssKtuhlslp+sGtlc.laYQ........K.ssplsshp.p..............spphlsaAuIs.ssssp.llls....saSthspplphY+lplsW.............s.....sptsp....hcs........p...........PSlplpchps.h...csh...s.............................p.lhpLo+Lcllstss.......ts.susp...I..Llsass.s..............t.sSllpRapLspps............phlpshFtpls.ppsss....t..p.h.phchhsclhhpppltsIssthhsh...............................................................hlshhacDGoIphhcpsohplhsss................scssshloshhssGFpa.........Ppls.......................htlSPohsullhhctpGp........th.....hthhpsshss.pp.t...h....susshAhta..shuhphshuuDDlslllphpl..lpplsccp...........tppahssllsthhshhsh.......shDt.scthlDKlls.ppsl.KshsLQhtLG..pht......sscsss.c.....luhllLpL+shsh........h...h..hs.....................hsc.-hlhSLlssh+Wll-hhsYlhppLh.l.........h.p.t.............p.s..polshhlhhuphsRthlhphh.ptlppl....pthltth........phaslh.spus...........p.....hh...h....phh..sss.Plshsha.....EpaLsclsshhpt.......................................................................t.pttsp.thE.pLllpuplPsp......................ltthsphllsps.......sssltschchsslahhDhshLplupsccsp..hhth....ttt.lh....................hDslpph.lthp................................................................tsplRRCsRCs..slotsspss........ps.......tshtt...Whhha....hRpClCGGhWh.p	.....................................................h..........t..hth.ah...t.t................................................s.hh..ht...s.hs.as...h.uhlhlp.sG.lt.h.h................................p.p..ph.p.......................thlthushs..tts......hlhh....s.s....tp.....lphh+l.lphs...................p..............................s..sh.h..h.................................................tlsplphl............t...t.....l...lh...hhp................................tohl.pap.ltpt...............lp.hh.phs.........................hph.t.h...t..l.tlt...hs................................................................hlhhhhpDuslphhpt.shp......................p....h.p..tsuhpa.....t...........................hS.s.h.hh.hp.ptp...............h.hht.........p..............................hthhh.......hthh........s.-.h....hhh.............p.hs.p................h.tphht.h.p.hph.................-h.........tl.p.....l....+s.h.lt...t...t.............tp.hs...phshlh.lpl.+p..h...............................................c....hl..l.t.hpWhhchhhhhhtpl..........................................................tp.....h....s.t..h...h...lt..h........th.h...............................t.t.................................................h.........h.....ps....ht.h......phL.th....................................................................................................................................................................t....-..h...ts..s........................h......hh.....................................h..............l.t....t.....................................................hD.hpp..h..............................................................................................................................................h+tCs.RCs....s...............................hh....h..h........C........h.............................................	0	32	68	132
+11468	PF11636	Troponin-I_N		Troponin I residues 1-32	Pollington J	anon	pdb_2jpw	Family	This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity [1]. 	25.00	25.00	26.70	25.50	18.30	17.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.93	0.72	-4.26	5	46	2009-01-15 18:05:59	2008-09-15 10:53:55	3	2	30	1	15	41	0	32.20	66	15.79	CHANGED	EA..EEEEsVsc.PKP.....PPsssPP.lRRKSSANYRSYAT	..................sc....pp-sstps.PAP.....uP......lRRRSSANYRAYAT.	0	1	1	3
+11469	PF11637	UvsW		ATP-dependant DNA helicase UvsW	Pollington J	anon	pdb_2jpn	Family	This family of proteins represents the DNA helicase UvsW from bacteriophage T4. The protein is a member of the monomeric SF2 helicase superfamily and shows structural homology to the eukaryotic SF2 helicase Rad54. UvsW is thought to have a role in recombination and the rescue of stalled replication forks [1].	25.00	25.00	71.20	70.40	19.10	18.00	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.62	0.72	-4.29	7	32	2009-01-15 18:05:59	2008-09-15 11:21:53	3	2	31	1	0	24	0	54.20	63	54.58	CHANGED	ltuCpTl-GLpELEKYYsKRhKEl..-lpsoDDISlRDAluG+RpEhEsps-stcE	IuSCQTlEGL-ELEtYYcKRsKEs..ELKDoDDISlRDALAGKRsELEspD--pEE...	0	0	0	0
+11470	PF11638	DnaA_N		DnaA N-terminal domain	Pollington J, Bateman A	anon	pdb_2jmp & Jackhmmer:B3CS04	Domain	This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known [1]. It is also found in three copies in some proteins such as Swiss:B5V0X4. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerisation.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.12	0.72	-4.40	116	3333	2012-10-02 15:09:17	2008-09-15 11:28:02	3	9	3077	2	743	2291	1830	62.70	28	14.06	CHANGED	sshWp.pltppLcppluppp..asoWlpslph.th.sss...............lhltsPspFhtsWlppp..........YhcpIpphhpp	...............plWppsLp.pLp..c..c..ls..tsp...........assWl+.s.lps...pl.pcss...............lhlhuP....Np.Fs..h.-Wlcs+..................YhshIpphh..t.......................	0	255	491	630
+11471	PF11639	HapK		REDY-like protein HapK	Pollington J	anon	pdb_2jdj	Family	This family of proteins represents HapK, a protein of unknown function, with two homologues PigK and RedY. The monomer structure of the protein contains a four-stranded anti parallel beta-sheet, three alpha-helices and a short C terminal tail which it uses for dimer formation [1]. The surface of HapK has a deep cavity with consists of a kinked helix and a beta-four strand. HapK could be involved in prodigiosin biosynthesis, specifically the binding of a bipyrrole intermediate such as HBM or MBM [1].	25.00	25.00	30.20	32.60	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.38	0.72	-3.40	4	20	2009-01-15 18:05:59	2008-09-15 11:51:59	3	2	19	2	9	20	14	102.90	37	68.24	CHANGED	McsIlHKIRLhDlucssAFEsWVpssDYATCPcLPSVRuFDVaRVSspt-APFHYlElIplou.ctFc+DMpTssFtsLVpsFspMAEVVEEluGEpLusGYpA	.....MpsIlH+I+L+DusssssFEpWVcsoDYssCspLsSVpuFpVh+l.S....s...s.s-....A.......P.aH...YlElIcVsuhctFs.p-MpTpsFpcLsscFsphA-VVpEhsGc.ltsGYt...............	0	6	7	7
+11472	PF11640	TAN		Telomere-length maintenance and DNA damage repair	Wood V, Coggill P	anon	Pfam-B_6865 (release 23.0)	Domain	ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage [1]. It is classified as an EC:2.7.11.1.	21.40	21.40	21.40	23.20	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.79	0.71	-4.49	24	182	2009-01-15 18:05:59	2008-09-15 12:47:21	3	6	154	0	117	188	0	151.90	24	6.10	CHANGED	Msshth....t.hhshLpSsKl+-Rsculpp.....Lppllpss...................pplssKshctlhcuLhphlppE+pta.........ppsssttuss...tpRLspsupslRhhlcpulc............ph+h+shpsllspIhchhhsss......tslhpslshDas+sL.sslLphssahccLs.tppWpp	..............................p..l...shptLpss+hp-Rpctl-c..................hcpllppspt...................pphppt..sa..cslFc.sLh+hlppEppsh.....................htpsssssust..ttp+lpchuuhlRhhl....cpusc............+htphpsptLlsalh-slhsss........hhtshut.DasphL.pslLshphahpclu.pppW..p...................................	0	24	52	89
+11473	PF11641	Antigen_Bd37		Glycosylphosphatidylinositol-anchored merozoite surface protein	Pollington J	anon	pdb_2jo7	Family	This family of proteins represents the core region of Bd37, a surface antigen of B.divergens which is GPI-anchored at the surface of the merozoite. The structure of the protein consists of mainly alpha folds and has three sub domains [1].	25.00	25.00	180.60	180.40	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.60	0.70	-5.06	4	14	2009-01-15 18:05:59	2008-09-15 13:13:05	3	1	2	1	0	15	0	205.90	60	73.07	CHANGED	VKoLE....slRpELKGQREsFLScIIcSsGshTILQLVsaLRVlDTDLLLpVDusKV-cAGtKVKAYL-pIGI+GpsVEEuLDNLMhKVh.clT+GTVEuSsQuTD.SEELKsLLLKFSEDLKAEQEhHu-Kctoc.-LLp...sLpsp+DELlKKFsthsPoFLToEDISuFLTVP-YGsPhsuuKWKpVE+KIpD...KLESSDlsT..-LKoLlAcLIEQREpMMDLLYGPhGca	..VKTL-....-LRpEL+uQREphLSpIIcSDGPFTILQLlsaLRlIDTDLLLKVDpshVccAGcKVKsYLEpIGIsG-SVEtuLDpLMhKVY.clT+GTVcSsspuTD.SE-LpoLLLKFSEDL+AEQEhHupKctuc.cLlp...ohtpp+-ELlKKFsslsPTFLTsEDlSuaLsVP-YGhPhsuschKpVEthIpt...KLEoS-l.s..pL+sLlAclI..REphMDLLYG..Gc..	0	0	0	0
+11474	PF11642	Blo-t-5		Mite allergen Blo t 5	Pollington J	anon	pdb_2jmh	Family	This family of proteins is Blo t 5, an allergen protein from Blomia tropicalis mites. This protein shoes strong reactivity with IgE in asthmatic and rhinitis patients. The structure of the protein contains three alpha helices which form a coiled-coil [1].	20.70	20.70	20.70	21.70	20.30	18.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.66	0.71	-4.34	7	41	2009-01-15 18:05:59	2008-09-15 13:22:55	3	2	9	8	0	46	1	113.40	44	85.15	CHANGED	hststhsspD-aRpEFDRLLlpphpc+hcclE+tLhpLScQlpELEKoKSK-lKtpILRElolu.sFlcGApGahERELKRTDLNhhE+aNFEtALuTuplLhKDLppLtK+VKulcoc	.........s.....spcDc.aRNEFD+LLhpphpcphcchEctLLtLocQls-LEcoKoKEhK-pIL.RElsls.shIcGu+sahpRELKRTDLNlhE+aNaEtAlsosclLhKDLcchpp+VKslc....	1	0	0	0
+11476	PF11644	DUF3256		Protein of unknown function (DUF3256)	Pollington J	anon	pdb_2p3p	Family	This family of proteins with unknown function appears to be restricted to Bacteroidales.	25.00	25.00	40.40	39.40	20.80	19.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.07	0.71	-4.81	9	96	2009-01-15 18:05:59	2008-09-15 14:03:42	3	1	96	2	13	81	0	195.30	36	92.44	CHANGED	hhsshulpAQEhKTlFlsMPDSlsPLLopVNRcDhI....DFlpSpMKApVcNpFGtpSEhpcLosDYlplQhospSohpMKlLsLsDoTpVlCsVoTVCuPACDSpl+FYTTDWK.LssssFl.olPshsDFlt.ssDoss.Ysap-ApppADM.LMKscLSc-sspLohThTTP-YhuKEstEKLcPFLR+.PlVYpWcsG+Fp	.......h....hulpAQ-h+slFlsMPDSlsPhLo+ssRpDhl....Dalp.uc.MKApVcNpFGspS..chpcLos..DYlplQhospSohpMK.lLslssosp........lICsVsTssu..PssDSclcFYos-Wc.Lssspah...shPshssF..lt.....ssDohs..cap-hppphDhhLhpscLSt-sspLohohoTPpYhucEstE+lcsaL+c.PllYpWpsspF..................	0	5	11	13
+11477	PF11645	PDDEXK_5	DUF3257;	PD-(D/E)XK endonuclease	Pollington J	anon	pdb_2ost	Family	This family of endonucleases includes a group I intron-encoded endonuclease [1]. This family belongs to the PD-(D/E)XK superfamily [2-3].	21.50	21.50	21.50	21.60	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.92	0.71	-4.52	2	21	2012-10-11 20:44:46	2008-09-15 14:40:57	3	1	20	4	4	13	7	133.70	33	94.51	CHANGED	STKLKGDIAEQAAILRALKLGWGVLKPLGDRLSYDLVFDVEGILLKVQVKSSWFSEKTGNYVVDNRRTRTNRRNIVRSPYRGNDFDFAVAYVEELELFYVFPVDVFISYGSEIHLVETDKRQRKPRSFGYREAWHLILQKGAAQKETSA	.........p.TK.KGDlA.ttAhlchlchGasVLpPhuD+.sYDLVh.............-.t-GlLh+VQVKouhhsppsGhh.VcpRsoh.oscpslsppphpsp-hD.ahlsYstph-.hYhFssclF.............................................h...h..pt.............................	0	2	4	4
+11478	PF11646	DUF3258		Protein of unknown function DUF3258	Pollington J	anon	pdb_2oq8	Family	This viral family are possible phage integrase proteins however this cannot be confirmed.	25.00	25.00	27.20	70.10	19.70	17.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.31	0.72	-3.88	4	7	2009-01-15 18:05:59	2008-09-15 14:47:15	3	2	7	4	2	11	0	101.90	39	21.51	CHANGED	P..hhuclYhchL.tph.K.sLpshpppDYARa.llWstls.DttI--..........ah.+DIuh.lDpsapLsK.hphcP.Yp+huWsEc.NhslsEDDlhhscolt+Y	.......hScVYh-FLpaKlpKtsLssKhppDYARhallWphlscDtsI-p..........Yps+DIGhFIDpCapLPK.hNhtP.YsKMuhsEclshDVsE-DhlsPKoVp+Y	0	0	1	1
+11479	PF11647	PMT_C		C-terminal region of Pasteurella multocida toxin residues 569-1285	Pollington J	anon	pdb_2ebf	Family	This family represents the C terminal region of Pasteurella multocida toxin (PMT) which displays a Trojan horse-like shape with three domains, C1, C2 and C3. The C3 domain possesses the Cys-His-Asp catalytic triad. PMT is an enzyme toxin carrying the cysteine protease-like catalytic triad which functions on the cytoplasmic face of the plasma membrane of target cells [1].	25.00	25.00	26.40	25.10	23.20	21.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.00	0.72	-4.36	14	184	2009-01-15 18:05:59	2008-09-15 15:09:40	3	27	97	6	23	185	1	66.70	40	3.18	CHANGED	osppLhcp..ups.GhsIGESapplhuchtllcsh..L....tpppVpsha.....l-chls-p.sushssh	.........oVsELl-s..ApVsGKlhGESYQpVlDtLs.hH....suhh.....t.-sVcpLh.pLp+pIEuYlhsHPsSGRspA......	0	1	5	16
+11480	PF11648	RIG-I_C-RD		C-terminal domain of RIG-I	Pollington J	anon	pdb_2qfb	Family	This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerisation. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity [1].	25.00	25.00	26.20	25.00	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.25	14	227	2009-01-15 18:05:59	2008-09-15 15:56:30	3	13	67	45	119	217	0	117.10	32	14.61	CHANGED	cphpLLCtsCpshsshusDlRpVEsoHaVslsssFp.chapspppPhs.tKhac-ap.supIpCtp..CucsWGhthhYKusp.LPsLKIcuhl....hEs.stsphphpKWpclsFphspF.Dhs-hstts	..............hpLLCp..pCpshsCpusDI+h.l.EpsH+Vsl.sss.Fp..phah.spt.p...p..s.t+pat..-ap..hs..upIhCpp.....Cup.sWGhhhha+s..hc...L..P..sLKI+sFV..h.hps....sts+p.ph.+KWpcls..hph.s.h.Dh.phs..t................................	0	33	40	72
+11481	PF11649	T4_neck-protein		Virus neck protein	Pollington J, Finn RD	anon	PRODOM	Family	This family of protein represents gene product 14, a major component of the neck in T4-like viruses along with gene product 13. Gene product 14 is rich is beta-sheets. The formation of the neck to the head of the bacteriophage is crucial for the tail attachment [1].	25.00	25.00	26.90	26.50	18.40	17.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.39	0.70	-5.09	12	78	2009-01-15 18:05:59	2008-09-16 09:11:18	3	2	77	0	0	70	1199	236.50	35	80.71	CHANGED	M......................s.psphhNPYl..........NhppasspQsLt-sLVsESIphpGl-hYYlPREaVshD.lhsEDhpoKFp+uaphtAYlsoaEGYpGpssahSKFGhplsDEhThsls.chFppps........DGp..........cPppGDLIYF.....Ph...sNsLFEIsaVEs.cPFYQhGcshhhclpsppFhYSuE-l...pPt.....lpc.-sl..-ph.t.slt.lhslsGhsDhsltp....htcssphpscstchhpph.slsscu...................osFssh	..............................................tpp.hssYl..........Nh..stapspQpLh-sLVsESIphhGh-lYYlPRphVshDhlauE-.psKFspA..aphtAYlssaEGapGttshhSKFG.hplpDElThsls.phFccpl............ssp................cP.pEGDLIYF.....Ph...sspLFEIsaVE.....s.cP.....FYQhG+shlhclpsphF.YS.sE-l...sss.....lpc.-sI......p....ph.t.slp.lhslsGhs-hshsp....htpssphpscstp.h.....l.sts........................s...............................................	0	0	0	0
+11482	PF11650	P22_Tail-4		P22 tail accessory factor	Pollington J, Finn RD	anon	PRODOM	Family	This tail accessory factor of the P22 virus is also referred to as gene product 4 (Gp4). The proteins structure consists of 60% alpha helices. Gp4 is the first tail accessory factor to be added to newly DNA-filled capsids during P22-morphogenesis. In solution, the protein acts as a monomer and has low structural stability. The interaction of gp4 with the portal protein involves the binding of two non-equivalent sets of six gp4 proteins [1]. Gp4 acts as a structural adaptor for gp10 and gp26, the other tail accessory factors [1].	19.40	19.40	19.40	22.70	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.79	0.71	-4.68	6	137	2009-01-15 18:05:59	2008-09-16 09:28:17	3	1	135	24	8	65	4	158.50	51	97.54	CHANGED	MsplhTKGDlVLhALRKhGlASNATLTDVEPQShEDGlNDLEsMMAEWh....upGI-lGYtFAssEps..PsPDD-oGLssphpsAVuapLhlRlhsDYulEPTs+lluoActuY-sLhhshlplPulcRRs..........DMPsGpGNpassasss+YYsc+t.....hssDss......ss	.......................M.plhTKGDlVLtALRKhGlASNATLTDVEPQShEDuVNDLEsMMAEWh....upGIsl.GYhFAssDps..PhPsD-pGLsspAhsAVhapLAsRlssDYuLEsospllosAchuh-tL....hKlsuhc.Rtp..........cMPsGSGNphssast.+Ya.tct......stD.sss............	1	3	3	5
+11483	PF11651	P22_CoatProtein		P22 coat protein - gene protein 5	Pollington J	anon	PRODOM	Family	This family of proteins represents gene product 5 from bacteriophage P22. This protein is involved in the formation of the pro-capsid shells in the bacteriophage. In total, there are 415 molecules of the coat protein which are arranged in an icosahedral shell [1].	23.70	23.70	24.30	23.80	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-11.94	0.70	-5.87	13	302	2012-10-03 06:22:39	2008-09-16 10:33:18	3	5	281	0	45	236	443	327.50	22	91.19	CHANGED	MANshLT..hslIscEslcslpspsshupslc+tYsspF....suhphGsolslhhPsphpststsshs.........sspslsEtpVslslsp.csVshphoucEhtLcls-hpcRhl+PAhppLAspl-uslht.............shtppsoNhVup...ssush..s.hsshtsAsstLspttlPps.sRpshhsPpspschuss.sshhtsu.ptspsAaccusl.sphuGhDhhhspslhstssGu.usuhTVsGusphss...................Tlslsuhss..........lptGDhhohAGVhtlp.lTKpsh...sp.ppFpVst.....usuusslpIhPshlssssss.sp....atsVssssAsssslohlsssssshh.NLhapcsAhsLsssPL.hPhtuuspshssoa....cGlSlRlhsthDtpscsspsRlDlLYGs.sslcP-h.ultlss	.........................................................................................t....h.hhpthl.th..t.hs.hsp..t..lp+.htsst......s.p.tssssl..hh.Pst.ps.....p....tp....shshss......ssssl.ptps.s.sphsp.cps.hphps..-....l..p.....t....p.hh.p...phl....p....sutptLA....ssl-ptl.u...p.......................hhhp.t.u..u..h.s.l..s.................s.....s.....s..sst.ps.......as.l.upstphlpstslsps..sphhlh..sPtshtp..ht.ts.st.h.ths..s...phsppA..h.c.supI..spl..uGhchhho.....sshh.....h.pts...u.s..s.hhlpst.p.t....................hlslssss.........hthGp.hphss..................................................................................................hht...h.hh......s...........................sh.h...................thth..u..................................................................	0	14	29	36
+11484	PF11652	DUF3259		Protein of unknown function (DUF3259)	Pollington J	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	34.20	48.80	21.00	18.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.89	0.72	-3.83	4	92	2009-01-15 18:05:59	2008-09-16 13:06:44	3	1	42	0	59	80	0	82.20	64	46.83	CHANGED	MplQDpQLAtQLhRLRu-Ip+LKl-QsC+hH+EMLsDATaELEEps-.uDL.CDlPhuuuhuLSTPLKhlGlTKMNINoRRFSLC	....MphQDpQLARQLhRLRu-Ip...+LKlEQsC+LH+cMLsDAoaEL.EEp....sE........uDL..hC-h...Phs...u.uhuL..SsPL+hIGlTKMNINSRRFSLC.	0	6	12	28
+11485	PF11653	VirionAssem_T7		Bacteriophage T7 virion assembly protein	Pollington J	anon	PRODOM	Family	This family of proteins represents the gene product 7.3 from T7 bacteriophage. The protein is localised to the tail and is thought to be important in virion assembly. Particles assembled in the absence of the protein fail to adsorb to cells [1].	25.00	25.00	26.00	25.60	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.30	0.72	-3.23	5	48	2009-09-11 12:45:27	2008-09-16 13:30:53	3	1	31	0	0	44	0	92.00	51	99.01	CHANGED	MG..KKIKKAVKKVsK.VpKl....s+.sttAuGGhLG..GGcstsp.V.......EAssP.As....AQlVEVP.cDcV-oED-uQTESu+KKARAuGKKuLSVARSSGGGINI	.......................................K.lpKshKpVsK................ht.st.pssGGhhG....GGpscsphs.............psPQAA.....AQlV....-VP.cc-VssED.-AQTESG+KKARAGGKKSLSVARSSGGGINI.............	0	0	0	0
+11486	PF11654	DUF2665		Protein of unknown function (DUF2665)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family are annotated as Non classical export proteins, however no specific function is known.	21.90	21.90	23.10	22.40	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-8.15	0.72	-4.39	8	66	2009-01-15 18:05:59	2008-09-16 13:38:40	3	3	66	0	48	65	0	46.30	35	57.78	CHANGED	YLISRslDPlLAlulGssSYYLaEp..Rs..GRPpGHoLNELlt++ascps	....YLISRhhDPlhAlhlGssAaalhpp..Rp....t+.pG+.plpp...ll..h.h.................................	0	16	28	44
+11487	PF11655	DUF2589		Protein of unknown function (DUF2589)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	21.00	21.00	22.30	21.90	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.98	0.71	-4.12	34	199	2009-01-15 18:05:59	2008-09-16 14:19:00	3	3	97	0	60	181	27	153.20	21	77.55	CHANGED	shssLIsG.hpAsspAQthluppthchlpphh.............pssp.............hshphphslssppt.............php.lplPLlsllshssLtlcclslcFshclss..spsppsppstshph......psp.t................sspppssp......psssssphplplphpppssPEGlt+ll-hhsps	....................shppllsu.htAsspAQthhup.pthshlpphhh............psst..................hhhthphphslsspp.........................p.t.lplPLlsllshssL.tl-cssl..sFphcl..ss.spsppspsshphph......................thp.thh................hthpsphuspppssp..........psspssphp..lplphptpt.PEult+ll-hhsp............................................	0	9	25	47
+11488	PF11656	DUF3811	ComReg_Spx;	YjbD family (DUF3811)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteobacteria proteins of unknown function. This family is unrelated to Pfam:PF03960 which contains a set of transcription factors that are also named YjbD.	21.50	21.50	48.00	47.90	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.98	0.72	-3.92	6	505	2009-01-15 18:05:59	2008-09-16 14:21:29	3	1	502	0	25	113	1	86.90	83	97.82	CHANGED	M.+LT.KDMTESEQRElKTLLD+ARhstGRsLTNuEsN+IK-EhI-KlMspREthAKtAR.......tE+KppphpP.opsTFSW..SAss.usRu+R	......LPRITQKEMTEREQRELKTLLDRARIAHGRsLTNSETNSIKKEYIDKLMsEREAEAKKAR.......QLKK..KQAYKPDsEASFSW..SANT.STRGRR.........	0	1	6	14
+11489	PF11657	Activator-TraM		Transcriptional activator TraM 	Pollington J, Finn RD	anon	PRODOM	Family	TraM is required for quorum dependence. It binds to and in-activates TraR which controls the replication of the tumour-inducing virulence plasmid. TraM interacts in a two-step process with DNA-TraR to form a large, stable anti-activation complex [1,2].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.66	0.71	-4.71	11	77	2009-01-15 18:05:59	2008-09-16 14:26:03	3	1	62	0	11	52	8	141.40	40	96.89	CHANGED	MsDcI-ElI+-IAsKHGIAVuRDDPILlLQTINsRLMpDSp+AQQEhL-pFKEELEuIApRWGsDAKsKAERlLNAALuASKEAMs+shp-uspuuAcAl+pEl-suLuc.lsu.lpcuR+luhhNllAuuhslhAAslslhshL	........sDcl-ElIcEIAsKHGIAluRDDPILlLQTINp+LhpDo....tpAQ...p-lL.-pFKpELEuIupRWu..-D....AKsKAE+hLNAALs......ASK-A...Mscs.hp...-us....ptuuc..ul+c...E...l.-sshsp.l..ts...lccu..R+luh...hNhlAushslhAuslslas......................................................................	1	2	5	10
+11490	PF11658	DUF3260		Protein of unknown function (DUF3260)	Pollington J	anon	Pfam-B_003054 (release 23.0)	Family	Some members in this family of proteins are annotated as YhjU however this cannot be confirmed. Currently this family has no known function.	24.80	24.80	38.30	38.30	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	518	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.78	0.70	-6.36	23	576	2009-01-15 18:05:59	2008-09-16 14:50:18	3	1	549	0	49	313	9	502.60	71	95.59	CHANGED	hWNlYFllKFuLaatGhlsFpsLhNLsFsshLll..Pls...pptl+hlRphlAlslulsLhaaDoaLPPhsRLhuQsupltsFShuYLlELluRFlshphlluhhllllsYhhlupWlRlosaV.........lsuLlhlslhshsssshshhsusss..........................sstspssstsssssssshsshLssFappEupRpssFss..sssupsFDlLVLsICSLuWDDL-sstlpsHPLhs+FDllFcNFNSATSYSGPAAIRLLRASCGQpuHssLYpPAs.pQCaLFsNLApLGFpspllhNHsGcFDsFLp.l+cp.GshpsPlhspsulssshpuFDGSPIacDhsVLspWhp.pR.psssstsAhaYNoIoLHDGNRlssu.th.sohsSYthRtp+Lh-DlspFhcpLcpSGR+lhVllVPEHGAAL+GD+hQluGLREIPoPsIsHVPVGlKllGh..tssppGsslpIspPoSYLAlSpLlu+llssssFpsss.shtpLspsLPpTphVuENssslVMphsu+.Yl+LsG.usW	.................G.WNFYFLVKFGLLWAGYLNFHPLLNLVFAAFLLM..PIP...+YpLHRLRHWIAlPlGFALFWHDTWLPGPpSIMSQGoQVAuFSosYLlDLlsRFINWQMIGAIFVLLVAWLFLSQWIRlTVFV.........VAILlWLNVLTLuGPuFoLWP.....AGQPTsTVTTTG............GNAAATVAssGssPV.lGD.hPAQTAPPTTANLNAWLNsFYsAEuKRKoTFPusLPu.DAQPF-LLVINICSLSWSDlEAAGLMSHPLWSHFDI.FKNFNSATSYSGPAAIRLLRASCGQsSHTsLYQPAs.N-CYLFDNLuKLGFTQHLMMsHNGpFGGFLKEVREN.GGMQoELMs.QosLPVhLLuFDGSPVYDDhAVLNRWLs.spE.+-p.....NSRSATFYNTLPLHDGNHaPGV....SKTADYKsRAQKhFDELDAFFTELEKSGRKVMVVVVPEHGGALKGDRMQVSGLRDIPSPSITcVPVGVKFFGM..KAPHpGAPIlI-QPSSaLAIS-LVVRllDGKlFTE.D..s.......VsWpKLTSsLPQTAPVSENuNAVVIQYQsKPYVRLNG.GDW....................	0	6	14	32
+11491	PF11659	DUF3261		Protein of unknown function (DUF3261)	Pollington J	anon	Pfam-B_003077 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	26.00	25.70	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.91	0.71	-4.63	32	248	2009-01-15 18:05:59	2008-09-16 14:52:44	3	1	246	0	60	186	11	157.50	39	79.73	CHANGED	lhsL.lLsuCup.p..pps.s.....lsls.ssplsLssssths............................................hshsQhlohphssp....p.......+pLhspLcl-sp.clsLsGhushGptLhsLsYDspslpsppt..hLsssl...scplLusl.LshWPhpuhpstLs...GhpLtsps............ppRp.lhspssph.............llcIcYpp	...............................................h.hsL.hLsGCSp..p..ppps.....pshLpsss..plsLPsPuhsss...........................................lstQQLlousasuc.....o.........poLLVhL..psDsp..+lsLAGLSulGhRLFhlsYD.u.pslcsEQu..llsspL.PPApQVLADlMLoaWPhuAWpspLs..sGWpLpDsu....................spRp.LhsssGpl.............ls-IpY..t............................................	0	9	19	40
+11492	PF11660	DUF3262		Protein of unknown function (DUF3262)	Pollinton J	anon	Pfam-B_003096 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	23.50	23.50	23.50	23.50	21.90	23.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.76	0.72	-3.88	24	210	2009-01-15 18:05:59	2008-09-16 15:02:28	3	2	173	0	64	172	6	74.10	33	90.38	CHANGED	MouAQtsAFpAu.SG.lsPsthsslhlGhllulLhLWusWAlhssYpGWusp.plsptshhtsslRhslLLlVlsaahh	......MssuQhuAFpAu..oG..hsPushshlhlGhlhulLLLWusWAhhosYpGWusp..plsptphhthslRhlhLhllhsFhhh.......	0	4	30	52
+11493	PF11661	DUF2986		Protein of unknown function (DUF2986)	Pollington J, Finn RD	anon	Pfam-B_003109 (release 23.0)	Family	This family of proteins has no known function.	21.30	21.30	23.70	49.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.27	0.72	-3.63	42	221	2009-01-15 18:05:59	2008-09-16 15:04:49	3	1	191	0	59	167	4	44.50	59	68.34	CHANGED	MNRKKKIsphLpp+sK+sNAKlps..ss...KP+YISKAER....tKltupsp	.MNRKKKIsQhLpp+tKKtsAKLcs...SN.....KP..+YISKAER....AKLsAcpt.......	0	6	14	39
+11494	PF11662	DUF3263		Protein of unknown function (DUF3263)	Pollington J	anon	Pfam-B_003189 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	22.30	22.30	22.30	22.40	21.80	22.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.33	0.72	-4.52	18	368	2009-01-15 18:05:59	2008-09-16 15:51:34	3	1	342	0	112	259	77	76.40	49	76.45	CHANGED	ssLocR-ppILcFERQWW+asGA..KEpAIR-pFulSuTRYYQlLNsLIDsPtALttDPMLV+RLRRLRssRp+sRuAR	......s.tLop+-+sILsFEcpWa+.......hu.Gu...KEpAIR....-phGlSusRYYQhLNtLlDcscAlstc..PhLVpRLRRlRu...pRp+uRuAp.....................	0	39	89	107
+11495	PF11663	Toxin_YhaV		Toxin with endonuclease activity YhaV	Pollington J, Finn RD	anon	Pfam-B_003231 (release 23.0)	Family	YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity [1].	22.80	22.80	23.20	51.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.86	0.71	-4.44	17	374	2009-01-15 18:05:59	2008-09-16 16:06:56	3	1	357	0	48	161	27	138.30	65	91.19	CHANGED	plaAHshFl-pL-tLhspVEph+t+DPpsYtp+sssKhLAAlh+Lhh-sIPtDPs+spaRQGsTLGs.c++HWhRA..KFhp.paRLFFRa..copu.KlIlhAWVNDEsThRsYGu+sDAYsVFp+MLspGpPP-DWssLLptupsp	.........................A.LYAHPCFQETYDALVAEVEsLKGK.DPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGS...GKNKDWSRVKFGA..GRYRLFFR.Y..SE.KE..KVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWEoLTpETEEs........	0	12	30	42
+11497	PF11665	DUF3265		Protein of unknown function (DUF3265)	Pollington J	anon	Pfam-B_001494 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Vibrio.	20.60	20.60	20.80	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.72	0.72	-6.86	0.72	-4.10	16	241	2009-01-15 18:05:59	2008-09-16 16:28:22	3	5	69	0	28	244	0	26.70	45	50.19	CHANGED	+sAhHFhaAlsFsscssstphulushsP	.+sAWHFaYALshVhKlVCuuhGIAhlTP........	0	0	0	15
+11498	PF11666	DUF2933		Protein of unknown function (DUF2933)	Pollington J, Finn RD	anon	Pfam-B_002197 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.30	20.30	20.30	20.30	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.08	0.72	-4.43	40	286	2009-01-15 18:05:59	2008-09-16 16:47:17	3	2	243	0	91	187	35	55.20	43	68.32	CHANGED	hlshhslAuaaLlsEHpAHl...hGhL...PaLLL.LACPLMHlFM.HGGHGsHupccsssps.s	..........................lshhulAuahLlpEHhuHl....hGhh...PaL..LL.LlCPL....MH...L....Fh...H...G.GH.GsHpccsspsp.p..............	0	15	45	74
+11499	PF11667	DUF3267		Protein of unknown function (DUF3267)	Pollington J	anon	Pfam-B_002418 (release 23.0)	Family	This family of proteins has no known function.	27.10	27.10	27.30	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.50	0.72	-3.86	44	858	2009-01-15 18:05:59	2008-09-16 16:53:05	3	1	553	0	83	438	6	109.10	28	60.12	CHANGED	lslllhl.hlHEhlHhlhahhhttp..pht.hthphthhhhash.sspsls+ppahlhhlsPhlllohlhhhlhhh....h..htsshhhhlhs....hpsuhsssDhhhhhhllpp..spsshlp	....................h.hhllhh.hlHEhIHhlhFhhapcs....Ksp.hth.phchl...h.hats.ssp..shsKhpFp.IhhlhPh..llloshhlhLhhh.................hhh...p..hhh.F.lhu....lpsuhshsDlhhltlllpp..spsphl...............	0	30	56	74
+11500	PF11668	Gp_UL130		HCMV glycoprotein pUL130	Pollington J	anon	Pfam-B_002736 (release 23.0)	Family	This family of proteins represents pUL130 from Human cytomegalovirus, a glycoprotein secreted from infected cells that is incorporated into the virion envelope as a Golgi-matured form. The protein promotes endothelial cell infection through a producer cell modification of the virion [1].	25.00	25.00	54.70	54.30	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.03	0.71	-4.71	4	61	2009-01-15 18:05:59	2008-09-17 09:14:16	3	1	11	0	0	55	0	141.30	64	69.22	CHANGED	aCP.haPSPPRshu.FouYcphssGPECsNpTLYlLaNRpGQpLIERPSsWVpKlsaYLSGRspsVFQ+Fs+sAoosoc.slpIos-DtKlFGAHMlPKpoKhLRalVpDGTchphC.M+lpTWA+shpsY.luFQsRlphTpAspps.ohCT+PNLlV	............YCPFlYPSPPRSP.QFSGFQpVsTGPECRNETLYLLYNREGQTLVERSSTWVKKVIWYLSGRNQTILQRMP+TASKPSDGNVQI.SVEDAKIF.GA....HM..VPKQTKLLRFVVNDGTRYQMCVMKLESWAHVF...RDYSVSFQVRLTFTEANNQ...T...YTFCTHPNLIV...............	0	0	0	0
+11501	PF11669	WBP-1		WW domain-binding protein 1	Pollington J	anon	Pfam-B_003402 (release 23.0)	Family	This family of proteins represents WBP-1, a ligand of the WW domain of Yes-associated protein. This protein has a proline-rich domain. WBP-1 does not bind to the SH3 domain [1].	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.04	0.72	-10.85	0.72	-3.94	9	225	2009-01-15 18:05:59	2008-09-17 10:46:17	3	5	71	0	128	194	0	96.00	42	32.88	CHANGED	YhC.-oGaCCGEotCC........................oYYYELWWFWLVWsllIlLuCCCsh+HRRsKpRL.....QpQQRQ+EINLlAYptApp......os.sh.hRhLssahLPsYEEVss+PsTPPPPYo	.........YhC..-s.GaCCG..p.o.....tCC.....................sY..YYELW.W.F.......W.......L...lWsl..l...I..l...L...S.CCCsh....+HR...Rs.KhRL.......QpQQRQ+EINL.hAYptApph........ss..h.....h......ph.hssah.PsYE-Vspp..P....s..oPPP.PYo........................................................	0	21	33	76
+11502	PF11670	MSP1a		Major surface protein 1a (MSP1a)	Pollington J, Finn RD	anon	Pfam-B_001532 (release 23.0)	Family	MSP1a is part of the A.marginale major surface protein 1 (MSP1) complex and exists as a heterodimer with MSP1b. The complex has adhesive functions in bovine erythrocytes invasion [1].	21.30	21.30	21.30	23.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.44	0.71	-4.38	3	306	2009-09-10 23:09:43	2008-09-17 11:25:55	3	4	4	0	1	364	0	102.80	79	77.43	CHANGED	MS.EYVSSQPADSSSAGGQQQESSVSSQSDQASTSSQLGsDSSSAuGQQQESSV.SQSDQASTSSQLGsDSSSAuGQQQESSV.SQSsQASTSSQLGTDWRQEh+SsVASVEYhLAARALISVGVYAAQupIApSpGCASLSVAEVEEI	............................sDSSSAuGQQQESSV.SQSsQASTSSQLG..sDSSSAuGQQQESSV.SQSsQASTSSQLG..sDSSSASGQQQESSV.SQSsQASTSSQLGs.D............................................................	0	0	0	1
+11503	PF11671	Apis_Csd		Complementary sex determiner protein	Pollington J	anon	Pfam-B_4678 (release 23.0)	Family	This family of proteins represents the complementary sex determiner in the honeybee. In the honeybee, the mechanism of sex determination depends on the csd gene which produces an SR-type protein. Males are homozygous while females are homozygous for the csd gene. Heterozygosity generates an active protein which initiates female development [2].	25.00	25.00	28.30	27.90	22.10	22.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.21	0.71	-4.40	5	496	2009-01-15 18:05:59	2008-09-17 11:44:59	3	6	18	0	8	464	0	126.60	68	61.76	CHANGED	TSRKRYSRSREREQKSYKNENSYREYRETSRERSRsRptRERSRE+KIISS.ss..NNYNYNNNYNN.N..pYNKh...........YYNINYIEQ..IPVPVYYGNFPPRPIMVRPWVsMQEQVPRFRYIGPLTPFPPRFIPPNtYR.RPPLNPRFRPMY	............TSRKRYSRSREREQKSYKNENSYRc.YRETS+ERSRDR.pERERS+E.+.....I....SShs.......s.......p..h....N...................N........h...p..N....s.....Y......Np.....p............p.ph................YY.N..IN.Y...IEQ......IP..V....P....l...YYG.NFPPcPh..tPWls.M.QcQlP...R.FR.a...IGP..T.sF.PRFIPP.NhYR..RP.P.LNPR..FtPh.........	0	2	2	8
+11504	PF11672	DUF3268		Protein of unknown function (DUF3268)	Pollington J	anon	Pfam-B_4693 (release 23.0)	Family	This family of proteins has no known function.	24.70	24.70	26.00	25.70	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.39	0.72	-3.94	13	115	2009-01-15 18:05:59	2008-09-17 12:50:20	3	2	104	0	24	97	7	101.90	37	68.03	CHANGED	tPlpCPYCuupspLsssphlYG.+phsshPhl.....YlC..ss...CcAYVGsHP......tTshPLGTLADtshRptRppAHcsF-pIWc..sppho.RocAYtWLApcLsl.s.ccsHlG	.......hCsYCGu.tuhL.sp.u....sth.Ys.hp.s..p...s..h.....alCss...CsAalGsHs.......ps..c..hPLGpLAsspLRpt+ppsH.tsh-slhp...............ss...thp...RscuYpWL...A...ppLGl.sht.sHhG..............................	0	4	10	18
+11505	PF11673	DUF3269		Protein of unknown function (DUF3269)	Pollington J	anon	Pfam-B_4706 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	25.70	25.40	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.40	0.72	-3.54	3	181	2009-01-15 18:05:59	2008-09-17 13:34:48	3	1	153	0	5	62	0	72.80	80	98.93	CHANGED	Ms.hEKYYLYRsDGTE-IKVtKcKDNVNsV+oLTGAHFS-EcKhMTDS-LK+FKAsHGLLYEEELGLQuTIFDI	....MP.KEKYYLYREDGTEDIKVIKYKDNsNEVYSLTGAHFSDE.KKIMTDSDLKRFKGAHGLLYEQELGLQATIFDI....	0	2	2	5
+11506	PF11674	DUF3270		Protein of unknown function (DUF3270)	Pollington J	anon	Pfam-B_4714 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Streptococcus.	25.00	25.00	25.70	25.60	23.70	21.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.14	0.72	-3.97	8	347	2009-01-15 18:05:59	2008-09-17 13:38:56	3	1	344	0	25	115	0	89.60	53	94.35	CHANGED	hsL++hpsa.c..DhpYQc...cphPcYQ-aQshsppss..KLcELlFFupIAsFClhTVLhoFlhLuhpLsohaAFslAhslS....LulhpshcphIK+	.............MPVRKLQS..Y.....Es-YQE...ppQhP+YQsYsPEApocA..sLKElLFFlNIAVF.CIshslFSFIFLALKLuTsLAFshAIuhS....LllLpltRslIK+.......	0	2	6	15
+11507	PF11675	DUF3271		Protein of unknown function (DUF3271)	Pollington J	anon	Pfam-B_4697 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Plasmodium.	20.40	20.40	20.60	21.50	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.75	0.70	-5.25	12	39	2009-09-10 14:53:48	2008-09-17 13:49:26	3	1	5	0	39	40	2	169.30	39	85.08	CHANGED	NIILSFFILVIFSNVK....AATFQDs.NsssPKsIuYsSVuQPhssFs+pccpHspYLDlINslh+DpScNhKYAYpGuNYHWlITDFDISIDNSSptLK+phScKtpEuLhhGosYFIuYIKDpIKaLlSpaMHKYDFEpNYtssLphLucDLKsLIYDcF-pchKpDLIKYEstPEscKh+cpAKchhcsLVpNSuhplpGYFIKlpcDusYhcLscspslYFsIsIsKs.uphsathKh.cs-lsEhlss	................NIIlSaFILsl.sNV+....uAoFQst.Nssps.........p.IuY.slspPhshhph.cppahpaLshINphhpcpscs.h.cYsapsssaHalITcFcl.IsNus..lpthh.ppt.p.h..us...h.hh...h.......h.pYsF.....t....h.ppLKs.h.spF..ph...hlp.p....p...................h.hps........................................................................................................	1	0	6	38
+11508	PF11676	DUF3272		Protein of unknown function (DUF3272)	Pollington J	anon	Pfam-B_4726 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Streptococcus.	25.00	25.00	41.60	41.50	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.78	0.72	-3.96	7	324	2009-01-15 18:05:59	2008-09-17 14:07:26	3	1	321	0	18	94	0	56.30	61	95.59	CHANGED	shpQFlhhAlhTshETYFFNtSlhoGpahhAhFauhLLhRslphsYhls+hsctl.K.....p+K	..hpQFlhhAlhTAhETYFFN-uhMTGRYIMAAFWAILLFRNFRVSYVMGKIVDlIDQ...chs+K..........	0	2	5	9
+11509	PF11677	DUF3273		Protein of unknown function (DUF3273)	Pollington J	anon	Pfam-B_4727 (release 23.0)	Family	Some members in this family of proteins are annotated as multi-transmembrane proteins however this cannot be confirmed. Currently this family has no known function.	25.00	25.00	25.40	25.20	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.80	0.70	-5.13	9	59	2009-01-15 18:05:59	2008-09-17 14:11:00	3	2	17	0	51	59	0	236.90	35	81.42	CHANGED	ssEsspsRGPpapPhhsFF.sh.LRhGFhlQhluhh.LhhluhashGt..huIhsF.LpAhPE...phussha.hlhhhhuhaLlGTLhIh.FplhssDDo..KtsRGaRAGoKhLttAoolshlShhLphVpa..lhusaahstpWhschttstusWlhahhupllsuFuLhlYGuuhFaLEsYHsEGTuEphuWlshhhFhhAGlsElL..hsFhssGshhoLhhL......lulhsuolWAhhFEPlhc+asspLpposlpN-.....hhKscpshuY	.........................sps.psRG.ph.PhhsaF......ssh.LRhGhhlQhhuhh.hhhh.hhshGs..hulhsF.Lpuhs-...phupuhhhhhhhhhuhallGslhlhsFQ.hlsDDo...p.sRGaRuGoKhLphAshlshluhhLphl.a..hhs.hahstpWhtchttstSpWhhahhuplhcuhuLhhYGhuhFhlEsYHsEGsuEtauahshhhFthuGlsElh..hhFhshush.sLhhh......huLhssslWAhhFEPlhp+hsspLpppslps-.....h.+.pph..Y............	0	17	27	43
+11510	PF11678	DUF3274		Protein of unknown function (DUF3274)	Pollington J	anon	Pfam-B_4733 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.94	0.70	-5.19	10	137	2009-01-15 18:05:59	2008-09-17 14:28:57	3	5	81	0	29	183	0	241.10	28	36.78	CHANGED	sohPAMssLtshRFaQRMWT+RpRsG......csVtVG..sPPtphsLRtcsEs+YPGuGss...........sshhupuslsps-pRhINGEsLpPPacPcM.asGEs........tphsGsso...........tuG....hDsPDDVstslALGNstAch+hhtlssp....ssstchppsctp...tuaN.pG+s.sDQTpsaRssssss.s............sthllhRcETPsEsRtRMppsscuhp-NSYHSulL+SsENHRWVTAMDVAIGQAcoLDDPsWRclLlAhADW+h........stcphcphp-Lss......ap+LStcsQcLlcAospYYcpGsFPupp	..............................................................................................................................................t..h.sh..L...tFaQRhaThh.R.t.........hlG...sst...hh...p.hh.ssth............hshh.pssh...p.hhlsu.tL..shtsph..tGp...........h.Gpss...........huG....h.t.Dshshshulus..h..p.....h..t......................t...h.t.tht.....hN...t...tppo...hph...tt...................thhhlpRpcT.Pp..EsRtphtp..s.ssthttsoaHSull..pssEspRhVsAhDlAIGpup.olDDs..s.ahphLhthADW+h..............s.t......p..t........at.t.p..tsp.hhpts..Yh.pG.hP...t........................................	1	3	12	18
+11511	PF11679	DUF3275		Protein of unknown function (DUF3275)	Pollington J	anon	Pfam-B_4743 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	25.00	25.00	58.10	33.20	19.80	22.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.49	0.70	-4.70	5	108	2009-01-15 18:05:59	2008-09-17 14:35:44	3	2	82	0	33	99	2	189.60	49	92.06	CHANGED	IsLPG.pLslRTIs.GRNG-FsVG+LtTsIGEFcVKDALLDQacEGKY+G-FVIocIaP+pYsuGG+hVsEIRApLDuMsLDuhspLScD-scchussEsDPLDE.Ptl.usossuSAPsPuPSPpsspPuSpRAo+D.h.chuPFGhcs.SsPAppsspASssc-sDA.......ELFGslWP...lGEsVKLDoTVDR+pLRpQssRLGpLG.YcLDF+pQhWshc	.........IslPG.pLslRTIp.GRNGsFsVGRLuTsIGpFslKDs.L-QY.EGKYcG-FlIppIhPpsYss.GGthhhEIRApLDuMTLsslDpLScDEA.cph.usp-lD...PLDE.....t..t.ssssuts..ttsp...t........tss.pussD.....sPFGhss.stPstts..s.ss..p-sDA...................tLFG.hlWP....LG-sVKLDoTlD.R+...tLRtQhsRLGp.LG.YthDhppQpWph.p...........................	0	4	20	28
+11512	PF11680	DUF3276		Protein of unknown function (DUF3276)	Pollington J	anon	Pfam-B_4744 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.20	22.20	22.20	23.90	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.66	0.71	-4.32	27	215	2009-01-15 18:05:59	2008-09-17 14:53:19	3	1	206	6	67	189	126	117.10	36	92.57	CHANGED	M..p-pc.h......-pE-lFS.Ksl+AG+RTYFFDV+uT+usDYYLTITESKKhspcDG...phpacKHKIaLYKEDFppFtEsLp-hhsaIhpcph.....p-Vho-capcs.pccppp.tt...pt...........spthpDlsF	..........................t......-+--lFS.Ksl+AG+.RTYFFDVKcsRt.sDhaLsITESKKhs...ss-G.....pF-KHKIFLYKEDFpcFhpsLp-slsa.Ipppph.....pcshpcp.tpps.pcpt..t..................................................................	0	32	60	65
+11513	PF11681	DUF3277		Protein of unknown function (DUF3277)	Pollington J	anon	Pfam-B_4749 (release 23.0)	Family	This family of proteins represents a putative bacteriophage protein. No function is currently known.	25.00	25.00	25.10	25.10	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.80	0.71	-4.71	7	159	2009-01-15 18:05:59	2008-09-17 15:46:29	3	1	142	0	23	117	4	138.20	38	96.58	CHANGED	Mu.TYSFhDVoASlsGPsGuhsLGYGsAsAEEGIslAhussKNTMTlGADGEsMHSLHADKSGpITlpLLKTSPhNpKLMAhYsAQSlsStLWGpNlIslpppsuGDlssuRusAFpKtPDhp.AKDGshlpWVFDssKIDphLGoa	......................................shthsh.ts..h...l.s.Gtusu-p.sIslshsuspsTMTlGADGEVh+SlpADKSGTlTlsLLpTS...PsNppLSh.hYNs.Q.p.t.Ss.s.saGs.sslsI+spsuuDlh.TApsstFpK.PD.stupsusshsW..sFcshclD...........................................................	0	1	9	16
+11514	PF11682	DUF3279		Protein of unknown function (DUF3279)	Pollington J	anon	Pfam-B_4753 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	26.60	25.90	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.57	4	650	2009-01-15 18:05:59	2008-09-17 17:06:46	3	1	218	0	13	267	1	116.50	50	91.63	CHANGED	phlKsaLA.sups+hlsAcpAtptshtchhC.hSCGssLpLp.tsDsQ.sWFEHDphslsE+thtpCsalcPEc+E.phl.+LpphshsshslscstpWaCVhCppcY.GcKhCsuCtTGlYShssspp	.........................hhhpsahA.DupG+hssA+pAtpt..shpchhC.h.CGssL....php.thDsp.PWFEHsp....sl.sE.+t..pCsalcPtc+Ehphl.....+LQphsss.shPVs...+htpWaCh.CccDY.G.E...+hCs+CtTGhaScths....................	0	0	1	4
+11515	PF11683	DUF3278		Protein of unknown function (DUF3278)	Pollington J	anon	Pfam-B_4766 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.40	24.40	24.90	25.00	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.15	9	428	2009-09-10 23:48:43	2008-09-17 17:07:30	3	2	313	0	30	252	1	124.50	34	72.54	CHANGED	MK.KEThs-KlIKpFYGIoGPLDEaKRppss+lGNpsFIhLahhhlhuslluhhLutpaPp..lAhhh...shlhlhshhsusYlhaps++ptlsslEl-htsp.ptp+phhhtulKhGlaaslhhahlhsL	................MK..KEshopKLI.K+hYGIsGPLDEa++pEs.s+lGNpsFIhLFalhhhusLIsLl..L...uh..ca...sp..plAhhYs...llhllsh.lh..usYl.s.hph.+.+ptl...st...hE.....p...h...h.s.t.....Kpp+.p....h....+....h.....u.lphGlhaulhhahh...h...............................	0	2	12	17
+11516	PF11684	DUF3280		Protein of unknown function (DUF2380)	Pollington J	anon	Pfam-B_4754 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	27.70	27.70	29.30	34.20	26.20	27.60	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.39	0.71	-3.98	26	121	2009-01-15 18:05:59	2008-09-18 09:19:21	3	3	79	0	53	129	9	129.80	30	79.71	CHANGED	s..tplAlFshphlDoSspssh.Gspss-tuRLshlsctlRctlsppGtapllDluPss...tpls+hsshtpCsGCctchApcLGA-hulsGpVQKVSNLILshNlhl+Ds.coGchlputsVDIRGNTD-SWpRGhpYl...l+splh	................plAlhshphhDsotpst...s.pss-ttRLthhpstl+ptlsppG.apl..lsh.s.sht...tthtp.......s.....s....htpCsuCthphAcphGA-hslsGhVpKlSsLIlslslhltDs....coGchltstss-lRusoD-oWpRuhpal...lcp.h..........................	0	15	30	36
+11517	PF11685	DUF3281		Protein of unknown function (DUF3281)	Pollington J	anon	Pfam-B_4757 (release 23.0)	Family	This family of bacterial proteins has no known function.	21.10	21.10	25.00	23.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.81	0.70	-5.22	6	95	2009-01-15 18:05:59	2008-09-18 09:36:49	3	3	24	0	4	63	1	178.40	40	67.00	CHANGED	KKKlLIGuslISSssLLuSCGKoETAsELRIVDpCNssNDLCcFELsDAlVSRYTNlLGKTIERVESQTPL+..cIpGTITWNsPAGAoLADNo-VpTcLGsuCQsDsCTANSNPTAYNLssGoNoISVSGhVTVsGKplDLAo-V.PslIDTttVtsS.HVFPTGsLPsGLTLpsLVssLNhsSc.....sAHGTFSusGSNL+ITCsoGYEWLDstsPsYG.phThucssRuVAhspW.p.....-psshhstptDshs.hTpNG.hsss..sshsWpAGCWs	.........................................KcKlLIuhsllSusslLtuCuKoETsp-LRIV.pCsss......pD..........hCchEhsss.sppYss.LsKpl.h.psppslp..tlptolpW...tsuphhs.ssl.sphs..tCpsssCssstNPsAaph...Gpp.lo..V.GphTVssK.......phslspph...s.sh..h..o..hhF.................................................................................................................................................................	0	4	4	4
+11518	PF11686	DUF3283		Protein of unknown function (DUF3283)	Pollington J	anon	Pfam-B_4778 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	26.00	35.80	24.90	24.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.77	0.72	-4.17	10	120	2009-01-15 18:05:59	2008-09-18 09:52:53	3	1	119	0	13	56	3	60.80	64	84.46	CHANGED	NLSLLPssEKN+IELDKQASFhVW+lKpAKsGPEsItcphpKlsDssE+saFcQulEKYK+	NLuLLsAsEKN+lELDKQASaLVW+LKpAKuGPEcIscQhuKIusEuEKpWFQQSlEKYKR.	0	1	4	9
+11519	PF11687	DUF3284		Domain of unknown function (DUF3284)	Pollington J	anon	Pfam-B_4781 (release 23.0)	Domain	This family of proteins with unknown function appears to be restricted to Firmicutes.	23.70	23.70	24.80	24.20	23.50	22.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.34	0.71	-4.37	15	343	2012-10-02 19:24:03	2008-09-18 10:54:25	3	1	293	0	39	178	1	119.40	28	84.05	CHANGED	M.cIspp...LshsscchFsplhpSshhDlcptTG+clthtpL.sGhsYpKpasstt....puplc..IT..chttsphYphpTsos+ssapscYplpsls-spoclpasEphpspshhtphNshlsshlhuh	.................................................McIspp...LplsucphasplhpSllhDl+psTG+p.l.ph.cpL.pGapY..hKph....up.st.....puplc....Is..chhtsphYphphsoscsp.hslpYplps.l.s-s.p.sclpYsEphpshs..hhp+hNshlhuhhhs.....................	0	11	25	28
+11520	PF11688	DUF3285		Protein of unknown function (DUF3285)	Pollington J	anon	Pfam-B_4791 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	82.00	81.70	19.20	17.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.12	0.72	-4.34	13	68	2009-01-15 18:05:59	2008-09-18 11:37:32	3	1	68	0	29	68	90	45.00	62	71.33	CHANGED	ssPsPSaVKLAMRNMVRKGupSLhHFuLTslGLLGhllhlAaLsR	...pPsPSaVKLAMRNMVRKGupSLhHFsLTslGLLGhLlslAaLsR.	0	5	19	27
+11522	PF11690	DUF3287		Protein of unknown function (DUF3287)	Pollington J	anon	Pfam-B_4801 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	27.00	27.00	27.70	27.70	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.42	0.71	-4.00	15	46	2009-01-15 18:05:59	2008-09-18 12:48:28	3	5	6	0	16	44	0	106.90	28	35.22	CHANGED	sp-h.s............t.........sPtah.sscsFpPu.........sVhhPpslh...phssc-+ccshsFhcpVtspH+chscc+pcLthKhQsl......hERch+tLEScPtcW.chshsplAcIPchLh.alctpspss	......................ps.sss.............ss.a..sscsF.Pu.........slhhPpshh...phssc-pccshsFhcplsspH+chpcc+pcLthKhppl.......ERch+tLEucPhpW.hhshsphA.lP..hh.hh..tst.s...................	0	15	15	15
+11523	PF11691	DUF3288		Protein of unknown function (DUF3288)	Pollington J	anon	Pfam-B_4815 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	28.00	37.00	22.50	16.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.11	0.72	-4.25	18	73	2009-01-15 18:05:59	2008-09-18 13:06:01	3	1	73	0	29	74	110	93.60	43	93.36	CHANGED	p-QsHPhappDRphVDpLLsps..P....s-.sLsELARLhIRYcsFPGAcDlppDL-+lLppWpLoc-cLap+TRplaucG............tVhsutssp-p-Dh	....-QpHP.appDRshVDpLLspc....P....s-hsLs-LARLhIRYpsFPGAc-IQpDL-+lLppWpL.Tc-cLFpKTRpIaupG............tVapstss.p-pps............	0	5	19	27
+11524	PF11692	DUF3289		Protein of unknown function (DUF3289)	Pollington J	anon	Pfam-B_4824 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	38.70	29.90	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.97	0.70	-5.13	6	334	2009-01-15 18:05:59	2008-09-18 16:00:26	3	6	270	0	35	192	3	246.80	54	93.64	CHANGED	Muss.......LuFPhslFpTQ++hNDYuADDM+sGDLo-ppLppsFsLpcVSs+lD......PY...pLp+hssFs..p.pah....st+hchlT+pcCscILFDEhRshShsFShaGsY+pLIs+hIsHMQpssGusFpDhpLspAh+-hIhsDpopsSolttIKpIlsctlDacptlaP.phpsphthsls+.shLPKFsRhpDpFNGLGIoVHDlaATpIoIcSLplppcpYpAlV+YpsQDHFGLDcpDI.ph+F+sFpFFRlWFVLQRaNcFGaKPFMTNMcAslpIsGs	........................................................h.s...........lshPCTLFETlshFDDaSADDMQYGDMsEpDF.LSLGLSDISAKVDPY...RLIK.Y.c..h....uP...s.shuh.....ssoSGsKISppECsDILFuEMK-LAK.MF.SFF.G...pYKoLIc-LI-HFRYG....NG.ssF+.Sp.................pLNhu.F+E...+Ipp..h....s.h.N.......S..slp....lIK....csI.-ss.I...sps.s.s.....h.Y..p......s...h....hhpp..I+......s.pLL.....u....SRL.......sKF........N.......cF.cDs.FNGLGISVHDIsAp+IoLhShQ.h........Y......s.h.uao.ATlHFhuQDHFGLDsTDI....KN......ph......Ys.+a....RF.FRIWFhLQRa+c..F..A.........FKPFhTNhpsh......ct.........................	0	10	16	23
+11525	PF11693	DUF2990		Protein of unknown function (DUF2990)	Pollington J	anon	Pfam-B_4826 (release 23.0)	Family	This family of proteins represents a fungal protein with unknown function.	21.10	21.10	21.40	22.00	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.96	0.72	-4.11	6	16	2009-09-10 22:19:26	2008-09-18 16:02:46	3	2	16	0	12	19	0	63.40	49	26.64	CHANGED	lusLsAsShAAPshFDNhYDYSDDLAEFLGRVSKaI-su.KDlhsuosTCDTSpIALPAaASGLP	..usLsAsuhAAPs..hF-slYDaSs-LAEFhu+VSKaI-su.+-lhs..uosoCDsSKIuLPuaASGLP....	0	1	3	9
+11526	PF11694	DUF3290		Protein of unknown function (DUF3290)	Pollington J	anon	Pfam-B_4838 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.74	0.71	-4.47	10	692	2009-01-15 18:05:59	2008-09-18 16:08:16	3	2	519	0	48	304	4	107.30	33	97.65	CHANGED	sFYoYsYlpoQtsppsahthlLhllhllshlhFshhYlRc+hsTKYRDLuIIulLhLlLhlGIQIssapsspsscsQspphlsFIcsVAcDhsVccs-VaVNoouhsDGhIV+Is...sphYplshss-sssYhLpKscLhs....chV.VcK	..........pFYshpYl.sp.s..pshlhhhhhhhhlhhhhhhhhhhhpt..pht.caR-l.hh..h..h..hhhphppap..pstpsp....pt.htFlc...lupp.tVs.pplhlNoot.t-G.hll+ls...p.aYch..ss-.p..pYhLpch.Lhp..p.lchl....................................................	2	11	24	31
+11527	PF11695	DUF3291		Domain of unknown function (DUF3291)	Pollington J	anon	Pfam-B_4872 (release 23.0)	Domain	This bacterial family of proteins has no known function.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.99	0.71	-4.76	34	150	2012-10-02 00:20:33	2008-09-18 16:51:27	3	2	130	0	59	154	71	131.50	34	84.44	CHANGED	LAQlNlu+.ltu.shDsPpls-FhssL-plNuLA-puPGFVWRhp...s-susu...T.shpshsDPt.....hllNhSVW-sl-uLpsFlacoh.Htphh+RR+EWF.cphscsphVLWWV.PsGHp.PolsEAhcRLpaL+ppGsostAFsa+psa	....................................LAplNluh.hht.Ph-s..P.....ht-FhssLs.lNuhA-pusGFlWRhp...s-.s.ssu.........sslphh.s-st.....................hlsNhSVWcsh-uLpsFsapsh.Htphh+..R+p-WF.pph..t.csthshWWV.ssGch.P.ohpEAhpRLphLcppGsoshAFsapp..........................................	0	17	43	53
+11528	PF11696	DUF3292		Protein of unknown function (DUF3292)	Pollington J	anon	Pfam-B_4874 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	23.70	23.70	24.70	23.70	22.30	23.60	hmmbuild  -o /dev/null HMM SEED	642	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.75	0.70	-6.65	8	115	2009-01-15 18:05:59	2008-09-18 16:53:43	3	4	60	0	98	119	2	426.50	31	86.56	CHANGED	GPTDSHsLSQl-s.-E..KGLAQKAGsos..cVoDlGWs.pSDpl-EclVsGLSNEDLWMLIRRFNKQIYaVKAVP-uPLQcLDLNRAEDEpFSPDKLRATLERFYTTVlVGLTsFhKHIARLRSWREPcRTssFCu......VYFlAWLLDhLlPTIFGhLlsLVlaPsoRpaLFPPAPlALVD..osTGGVQKPKAGVLGSHDSlTGAPEKYKGEAAEQEASNLlsSlAoVAVGSAAGKHDQGsP-s.....APMEuSVPDAhDlsu+uADAQuAAtG-sPs-sHDKTRcPMKcTVhNuANpuMRVlSDIsDsaERFuNALSPTPPFsusTPpLRLuGlLuuGhLsSLlTSSYVFlKhuTFhlGhuFFGDPllQRslsYLN+caPpWp+LL-LQNoLLKGVPTNAQLTLTLLRIGEuNuAPLPPPPSS.......SL+KsPopPAolsccplsL.sASppEIspAAAP-Ppsssscpcppsc..K...KKshGuRlluFF+GTTATGIEoKLAlDRsRAtAGSpHAKN+lGlL++KGccTL.PhGPlcFDARYKGKRGsVVIDSSpcPPlLYFTTD.oshLsDhRLEsRKKGoVLFsIPVTDIpEhRKIGGLGWKGKLlsGWAVG.oKEVVDGLVIsG.ccscQpYQLTAMpsRNpLFNRLVAIDGQVWESa	.................................t....................................................................hh.sh.sp...ph........a.h...................s.tthDh..up..ppphs..spplRuplERhYhslh.thhthh..pclhRLhoW..p..-..RTthhhh...................sY.huWhhshlhshh.hhhhhLl.h.s...R.hhFPsss.uhhs....psu.shtps.ts.huspsshT..Gus..cphc.GEusEp...EA...pshltuh.sslsh......tshs.up..s.....t.s.....t.........................t...tt....t......t.............................................tscsc..h.........tth.........h.t.th.t..hphhtth.D.hE+hus.................hh.....................a..........h.h....hh...hh.h..hhhs..hhh+..shhhGhshFG.pPll.......hhthlsp.hspWpp.h.....hphpp..o....l.h+GlPTsuQLslTLLRlGEhstsPlP.sPP..............................................................t..t..........................s.tt.....httt.t.........t................t......t...............................t.t...phhthh+t.s..htts..hpsththsphht..h.s.....t........s+p.hluhl...................t..............................................GPhp.......F.s+hptppGhhhlst..t....t............s...l.a...............stt....................................................ts................aphslt-l.phpKht......G...hGh.pt+hh...sths...tp.......chhDGh.l.....p..tpth.......hsuh..RptlFNRLhuhst.ph.Wp..........................................	0	30	49	83
+11529	PF11697	DUF3293		Protein of unknown function (DUF3293)	Pollington J	anon	Pfam-B_4879 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.50	25.30	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.37	0.72	-3.86	40	218	2009-01-15 18:05:59	2008-09-18 16:58:22	3	6	213	0	70	177	62	70.30	36	47.65	CHANGED	ITAaNPhS.phhosppNphtsppLtpcL...tphshshh..sshG....tssst...sW.hEcSahl.slshp....pAhpLGpcFpQNAI	.....ITAaNPtS.....phlSsp-NphpsppLtppL...hph.shs..hh..ps.s........sssph...pW.hEcSasV.s..hshs.......pAhpLupcFsQNAI....................	0	17	37	57
+11530	PF11698	V-ATPase_H_C		V-ATPase subunit H	Mifsud W	anon	Pfam-B_2481 (release 6.5)	Family	The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer.  This domain corresponds to the C terminal domain of the H subunit of V-ATPase.  The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation [3].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.44	0.71	-4.18	34	388	2012-10-11 20:01:02	2008-09-24 15:29:57	3	8	307	1	258	379	5	116.70	42	25.79	CHANGED	+phooFDcYhuElpSGpLcW.SPsHps........ppFWpENsp+h.c-ssacll+pLsclL..............ppop..DshsLAVACpDlGchl+h.aPpG+sll...pphssKtclMpLhsc..sDppV+hpALhulQ+lhspsWc	................t.pLooFDEYssElpS.G+L.cW..SPsH+s........ppF..W+ENAt+h..p-csacll+hLsclL................psSp....DsplL.A..V.As..aDlGcaV+..............p.....a.Pc.G..+pll...-pLG...uKphVMpLhs..c..c..DppVRapALhAlQ+lhhpsap.........................	0	97	150	216
+11531	PF11699	CENP-C_C	Mif2;	Mif2/CENP-C like	Mistry J, Wood V	anon	Manual	Domain	CENP-C_C is a C-terminal family of fungal and eukaryote proteins necessary for centromere formation. CENP-C is the inner-kinetochore centromere (CEN) binding protein.  In the budding-yeast, Mif2, the yeast homologue, binds in the CDEIII region of the centromere, and has been shown to recruit a substantial subset of all inner and outer kinetochore proteins [1]. Mif2 adopts a cupin fold and is extremely similar both in polypeptide chain conformation and in dimer geometry to the dimerisation domain of a bacterial transcription factor [1]. The Mif2 dimer appears to be part of an enhanceosome-like structure that nucleates kinetochore assembly in budding yeast [1]. This C-terminal domain is the region via which CENP-C localises to centromeres throughout the cell cycle 2,3].	29.00	29.00	29.00	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.83	0.72	-4.00	11	190	2012-10-10 13:59:34	2008-09-25 10:52:40	3	10	165	2	133	209	11	84.50	36	12.58	CHANGED	F+htKhhsp.s.FhuoGhlcLPs.uu.KpspsS+csphlFaVhpGtlpVolpcspFhhupGshFQVPpGNpYsltNht.sc-ApLFFsQ	..................h+htKhhsp.s.FhuuG.hlcLPP.sutKp.ps.oppsp.h.lFaVhpGplpVTl.........pc.....spFh.lspGshF.VPp.GN...hYslpNhh.spputlaFsQ.............	0	37	73	106
+11532	PF11700	ATG22		Vacuole effluxer Atg22 like	Wood V, Mistry J	anon	Pfam-B_14077 (release 22.0)	Family	Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy [1].  This family also includes other transporter proteins.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.52	0.70	-6.02	50	1392	2012-10-03 03:33:39	2008-09-25 16:14:42	3	4	1200	0	527	2826	2253	417.40	25	93.84	CHANGED	so++ElhuWYhYsauspsaslsshuoalPhhlpphucp.tGh.hssp..sC.........................................................tsspCllhhhG..hplsssSashYshulSshlQullhlsluuhAD.....ausaRKplLlsFuhlGuhsshhahhl.ssppa....hluulLhllus.ssa....us.shVhhNSaLPhLscspsphptttt..............................................tt.......t..t..h........................................................oplSuhGhulGaluullltllslhllhshpss...........shsl......plslhlsGhWWhlaolPshhhL+s+su.......................tthpshhsh..lhhua+pLhpsh..+psppL+pshlFLsuWFlluDulsTlsususlaupspLshssss.....LshlsllshhsuslGuhhas.hlsc+hslpsp.........psllshlhhhtllslaG........hlGhh.t......hhGhppsWE...........hashushYGlshGulpShsRShaupllP......GpE..utFFuLauls-KuSShlGPhllGhIhDtT..G...................slRsu..........FhFLslLhllslslh.hhlsl-+G+c-ut	...........................................................................................................................................................................................t......huWhhaDauspsa.shhl.h.o.h.h...h.shah.t.s.h.s.......................................................................................................s.....h.ps.s.u..hh...a.shu....luslllul.luPllGshAD..........ht.uh.++...h...hl.h..h...h....s...h.l..s...s..h...ss..h.h...h.....h....hl.....s..ssth...................hhsl..sl...h....h..l..u....t...luh........ss..u.l..hYs....uh.L..splsssc..ph........................................................................................................................................................................................s+lSuh.Ga.uhGY...l.Gu.hls.....h.l..l.s..l.h...h.h.h.t.spts.............................t.shs.h..............R.ls.h.hh.sAlWa...h.l..F.s.lPh..hh..hl..cp.t..........................................................................................h.t.h.tph.....lt.tu.a.p...c...L.....h...p.......o.....l.......p..p...l..p....c...h..+..s........l....h...h....F..L..l.A...h..hh...a..p..DGl...s...s....l..hs....hu.s.ha.u.t.........t..t..h..........G.hs...ssp...............lll.h...h.l.l.s...p....l..s..A...h......h.uul....l...hG....hl.sc...+.h.Gs..+................ph.l....h..h...s.l....h..hh..h.h.l.s..h.h....u..............h.h..............................h.p..s.s.ht.....................F.a.l.h.u..h...l...l....G.h.h........h..G..s...h.Q...u...h...S...R...Shhu...cl.hP..........spp.......upaFGh.Ys.ls.G..Ks.suhlGPhl..h...uhh.sp..ho.....G.............................s.h..p.....h.u....................hh..s...l..h.l..l.h.l..l..Ghhlh...hhl...........t................................................................................................................................	0	195	351	455
+11533	PF11701	UNC45-central		Myosin-binding striated muscle assembly central	Wood V, Coggill P	anon	manual	Family	The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats Pfam:PF00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organised myofibrils [1]. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins [2]. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known [3].	25.00	25.00	25.10	29.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.77	0.71	-4.58	31	280	2009-01-15 18:05:59	2008-09-26 10:22:29	3	10	207	3	188	266	1	194.20	28	23.10	CHANGED	sspplcslLppLs.......................................................................................phstssRshAslhhs+h...L...csppcshpchhscalpshl.....pcsch-..................................shlhshsslsslaPsss-lsuslhhsc.....shhthlhshss............tcscphphssLELLsuAChscssRphlscphhphLcphhppspppt..........................hphhAslsLsKl	.............................................................................................................t..cplchllspLh...........................................................................................h.lssssRhhAolhls+l...................L.....-st+-p...a...pchhpcalpsph.....ppts.h-..................................splpAhpsloslh.ussDlusplhttc.....Glh.ph.llsLss............scpcp.phsslEhLhtAssctsptshIhppslslLcclhppscs-p...........................l+lhAhVuLsKL..................	0	46	82	138
+11534	PF11702	DUF3295		Protein of unknown function (DUF3295)	Wood V, Coggill P	anon	Wood V, Chahwan C	Family	This family is conserved in fungi but the function is not known.	21.40	21.40	23.90	23.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.92	0.70	-5.51	9	124	2009-09-14 14:02:36	2008-09-29 10:57:28	3	5	88	0	107	121	0	354.50	33	70.17	CHANGED	pptuuDlPELSuSV-SssS-pApchppphcp.......................Phs.th+PslhRpDSh.uShuRG+E+HlTShsLE+MVloIp..EKKsLEPLusshssluP....ht..sppspPp.ssSpoospc.s...........p.hpsoESsooousssNsS-.uu..slssusTSsouothhsp.......sSllRGF..SPS.lSoShRSpsphussPsPs.......psusshK.t..KKKtuhFTLGGSSGs-.EsSF-DRh...............shpss++poL..............Ss-hp+usssp................KKssoFccpV.sh+shp-ps.-sD.sthps---.VsESAI..-DD-DSDW.EDSlpESGpuSl--+phFQRVDS+PN.LsS..RRSLLThMhHQss+h....s.sSRSosALpRSR.ToPNGPSlsASPs-sDEtsLhM.RG...........splPRScshlh+sos.pSsuH....SPRTTRRNMLATELTESLRRpLLWERpQKuAT..ANAhLKRRHTupD.hANLppYPp......................sssscDK......Dst..ssSaN+Ys.chG.hpYHspGW	..............................................................................................t......hP..StShtS..s............................................c..h.t.............phhss.thtphh..l......pt........h.................................................................................................................................................................................................................t....p.p...hasl.GsS.ss..t.........t......................................................ott..tps...............................................h.sshtp..p............pshpt......p............p..spp-.l..s...ESAI..t...-D-....ss-W..EDShp.-SGpuSh--c..hFpRV.-S....+s..s.LsS.............R.SLlT.hhht.psp...+............s.sSpSosAl.p.s.R.....sssshssSP....c..s--...ssLhM..+u.................chP+Sps..hhshs....tthtt...........SPRTTRRNMLATELTESLRRpLLWERQQK..sss.....ss...AhhKRRHTupD.hssLppaPt..................................s.ht.tsp......p........thsphh...p...s..tYHspGW...........................................................................	0	21	50	91
+11535	PF11703	UPF0506		UPF0506	Bateman A, Ranganathan S	anon	Ranganathan S	Domain	This uncharacterised family is found in Schistosoma genomes. Although uncharacterised it appears to belong to the knottin fold. The sequence is composed of two repeats of a 6 cysteine motif.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.82	0.72	-4.01	11	31	2012-10-01 22:06:18	2008-09-30 15:03:58	3	2	6	0	18	81	0	56.50	41	53.64	CHANGED	CRo.GQhCSRThF+RCCGNLVCQL+GaFNGsCVpCLAEt+FChhSSECCScRCRhFRCR	...........C+phGp.Cs+ThF.p+CCG.shlCpLpu.FpGpCV..p........CLstsphChpss-CCSt+Cphh+C+.......	0	17	18	18
+11536	PF11704	Folliculin		Vesicle coat protein involved in Golgi to plasma membrane transport	Wood V, Coggill P	anon	Pfam-B_3276 (release 23.0), ADDA_17305	Family	In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex [1]. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterised by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases [2].	21.10	21.10	22.40	21.40	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.94	0.71	-4.67	20	292	2009-01-15 18:05:59	2008-10-02 11:05:11	3	3	213	0	195	274	0	170.90	24	32.06	CHANGED	stsaVSopaPssspcYshLpphsh+oLSsEs..............shsusPlhFGDshcGasluhsFKlpDspARGscR+Yullllscsc........hp.LhpsWsalsptFsclIshIpppspp...tppptpppppsspps...................................sth.ss..........hhRtpshpps+SLsELTsD-tIFl+lHtahshlLpslst	....................................h...alShp.s..st.athlpp.shR........sLStEh.............................................tsscsuslhFGDs.ppG.a.shuatFplhD.pARGhpRhYullhlsscc.........t.lhppashlhsthp.c...lhpplpstsc+hh..tpppttppp.ts.p.s...........................................................t...s..............p........t.....t.........tsRsLsplssp..hahplH..hs...lL.th.s........................................................................	0	45	80	143
+11537	PF11705	RNA_pol_3_Rpc31		DNA-directed RNA polymerase III subunit Rpc31	Wood V, Coggill P	anon	Pfam-B_203281 (release 23.0)	Family	RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain [1].	28.90	28.90	28.90	28.90	27.40	28.60	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.97	0.70	-4.42	17	327	2009-01-15 18:05:59	2008-10-02 11:50:45	3	7	238	0	222	301	0	213.80	25	92.96	CHANGED	MS.......hRsuutsshs...........shsslsashs..tth..stssss.aPph.slPls..t.ssscEchhsthhhsatst.h+-uPaYTssh..t...............t.tt.............t...pcGlpRYSDKYppp++hssolcp..cP.aphchFPcELatshthsppt.pth.......s+h+pcssl.ph.......p.D.s.thphLE.Khpp..sp-.-ctpptct...........---cp-E-.D-Da....D---D..sDY.AEpYFDsG-t......DDhsD...................................tssa	....................................................................................................Mu........RGtu.tut.hsh................shptls.h.sts...t...................sh...pP.......s....slFP.........sh...hP.ls.....h.hsp.p-chhlthttphppt.h.+puPaahtst...t.....................................................................ppslcRYSc.+.Y.pt..t.p............t.....ph.ph........ps..hs..h..chhPp.ELhtphph...pp.p.t.........t.h..h....................sphttp..sh..t.............................t-....p..ch...p...t....L..EtKt..p.p...t.s.....p.-p-ptpptpp......................cccpc--...t..t---h.....-.--.p.-..tsDY.hppYFD.sG-s......D.D..-..............ts..................................	0	59	105	164
+11538	PF11706	zf-CGNR		CGNR zinc finger	Bateman A	anon	Pfam-B_19432 (release 10.0)	Domain	This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	20.80	20.80	21.10	20.90	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.56	0.72	-4.45	80	961	2009-01-15 18:05:59	2008-10-03 09:25:53	3	5	409	1	366	972	15	43.60	41	22.67	CHANGED	Rl+tC...ssssCshhFlDpS+sssRRWCSM.......spCGNRsKsspaRtRp	............RL+tC.....ts.ssCphhFlDpS+stpRRWCoh.......psCGNRt+sttaRsRp........	0	143	279	331
+11539	PF11707	Npa1		Ribosome 60S biogenesis N-terminal	Wood V, Coggill P	anon	Pfam-B_2493 (release 23.0)	Family	Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits [1]. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre [2]. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.	22.10	22.10	22.40	23.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.91	0.70	-5.44	42	265	2009-01-15 18:05:59	2008-10-03 11:36:46	3	8	231	0	187	273	0	302.70	22	18.51	CHANGED	sths-lhpsWshhspsss..shhshlsplLsthlthlssphp....hpphG.sl................s+hlLpp..c......hchl.h+uLsutc.............plhp..ssLcLLsplVp.suuthAcclhssh..ch..shphh.phh..pppphtp.ptt..............olRpshlcFhLuhLphs.ssth+pclLpp+ch.hsshhctlpp.DshpslhplLpslcscllp-p.sls+stKsclasphsLp+lss.LYthcsp........................slschs+chLhtlsTssphGlhhssstha.tt......................................h.ppphplpNphL.hpllp.tL+PtpsshptpL.......llpIlcssPELlusYhsch.tphp....P+hossWhuts	......................................................h....phhphaphhtt.tpp.....h.hl.thLthhlhhhssphp......ht.hu.tl....................s+hllpp.c......hchl.csLsupp...............phhp...ssLpLLsth...Vs.pusthAcplhpph..ch..shpslsphhphpctphtt....................................slRpshlpFhLuhLth.....s..ssthhpplLpp...+ph...hsshhct.lpp.Dshphlh.lLpsLcppll.............p..........s.............p.sls+..stKsphFspt..sL.pplss..LYshpst...................................................................t..tltchsHphLhtlC...o...s.p.pGlhh.ss....................................................t.tp.th.tht.NthL.hphlp...hl.+.shp...ss.hptcL.......llpIhcssP-LlssYhpph.hpht....P+ho.stWhs........................	0	56	98	151
+11540	PF11708	Slu7		Pre-mRNA splicing Prp18-interacting factor	Wood V, Coggill P	anon	Pfam-B_999 (release 23.0)	Domain	The spliceosome, an assembly of snRNAs (U1, U2, U4/U6, and U5) and proteins, catalyses the excision of introns from pre-mRNAs in two successive trans-esterification reactions. Step 2 depends upon integral spliceosome constituents such as U5 snRNA and Prp8 and non-spliceosomal proteins Prp16, Slu7, Prp18, and Prp22. ATP hydrolysis by the DEAH-box enzyme Prp16 promotes a conformational change in the spliceosome that leads to protection of the 3'ss from targeted RNase H cleavage. This change, which probably reflects binding of the 3'ss PyAG in the catalytic centre of the spliceosome, requires the ordered recruitment of Slu7, Prp18, and Prp22 to the spliceosome. There is a close functional relationship between Prp8, Prp18, and Slu7, and Prp18 interacts with Slu7, so that together they recruit Prp22 to the spliceosome. Most members of the family carry a zinc-finger of the CCHC-type upstream of this domain.	22.90	22.90	24.80	23.10	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.99	0.70	-4.61	41	344	2009-01-15 18:05:59	2008-10-03 11:54:42	3	8	276	0	246	345	2	231.90	39	50.39	CHANGED	phsaDuKRDRWsGYDsspacpVl-ca-ph-pt+cphptpp.................................sctttcpspst-ptpthhccs-h...................spppps..ssRsLRlREDTAKYLhNLcssSA.......hYDPKoRsh+-ss........t.ssthhts-sFlR.toG-....utchpchptaAWEstc+Gs...............................slclpAsPTphElhtKchppc.+....-pt+ppp+pslhcKYGspp...h.t..hp.hlspoEphhchpt.......httpths+SpatEDlhhpsHspVWGS	.......................hsaDuKRDRWNGYDs.p.-a.p.p.ll.--.Ypch-tt++ph+tpp.......................................................................................sptpt-p.spps-p.cpphs-c.-hs...........................phssppphssRNLRIR.EDsAKYLhNLDs.sSA...........hYDPKTRuM+-ss..h..............tts.sts.asu-NFhR.hoG-....shphtphQhaAWEu.c+Gs..........................................................................clHlpAsPTphEhLhKphc.c+.......-ph+pp....p+psll-KYGupc...thp.s.s.pc.....h...hl.spoEpaVEYsctGt.....................lKGt.+thspSKYtEDlhhsNHTslWGS..................................	0	88	139	206
+11541	PF11709	Mit_ribos_Mrp51		Mitochondrial ribosomal protein subunit 	Wood V, Coggill P	anon	Pfam-B_4972 (release 23.0)	Family	This family is the mitochondrial ribosomal small-subunit protein Mrp51. Its function is not entirely clear, but deletion of the MRP51 gene completely blocked mitochondrial gene expression.	21.80	21.80	22.10	21.80	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.85	0.70	-5.21	20	145	2009-01-15 18:05:59	2008-10-03 12:51:24	3	4	133	0	108	143	0	327.90	26	79.88	CHANGED	Mutt.......husLLRsSRlAplspsh.sh.psstp.............hPTHQlItT.sSShtR.u-WGLKpsLPs+hso.....palphN-lDThcclsDaEssu.saphsph+FQEhGlslsts................sppsPlFpstsspo..sppsshpshhs...........ph.hhsshosuchpchLpp....lssh+scFppaLhcptsct.................................................hsspsltchltcFLs..............................tsspphsspusschpuouGLSYs.pGpL.........psoPNGVptphlsPGRhl.....psscp.hsAlGGhVAsssss..................tsshhpthsschsRptph.aclpcAplsp.sGplhltssss	.....................................s.......p.hupLLRpSRlhtlspsh...ststtp................aPh+QsItT.sSohtR.u-WGLKpslPtK.ss...............shlpls.p.lDThEpl.T-Fcssu.spthsht+aQEhslPlshsh..................................................................................spp.pshFcsp.css...sts.shts.ht..................................................................phsh...hsshots-hpchLp+....l+ph+scFpphLhcphspp.....hp....................................................................tssttltsh.....lhcFLsh.s.................................................tsps.hs..ppssspspsouGLSY.pssth.................ppp.....psl...s+hl......hPtphh......tttpt..hhuluGhlsps..t........................t.stht..th.ssh..tttph.hps.pAplsp.pGpl.ltst.s....................................................................................................	1	29	59	91
+11542	PF11710	Git3		G protein-coupled glucose receptor regulating Gpa2	Wood V, Coggill P	anon	Pfam-B_11657 (release 23.0)	Domain	Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail [1]. This is the conserved N-terminus of these proteins, and the C-terminal conserved region is now in family Git3_C.	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.37	0.71	-4.76	19	259	2012-10-03 04:04:29	2008-10-03 13:01:14	3	4	124	0	213	414	3	195.20	24	38.37	CHANGED	sht.RlluIsuSshSlhusllulYhhhsIs.RR+.............lFRHp............LIhhLlhhDhlKAllLllYPshlLs...psssYssssFCpllGFFTAhuIEGu.................DlAIlsFAlHhulLIF+Ps............pssphEGGLY+aRhalYslsh.llPlllASLAFIs.............................tsGYpshssWCYLPscPhWYRLVLSWlPRYhIhlsIhsIYhsIYhaVp+chcpl	............................................................................................................hh.......l..shu..shu.lh.u...h..h..h.s...h...hh..h.h.h.h.....p.h.h...................haR.+...p.............................................................LIhs....Ll.lu...Dhhpulsh.l.l........sh..hhlt....ps..t..l..h..s..s...s..s..h.C.hpGahhp...hu.s....uo.................s.hhllsIAlH.T.a.lhlhps.......................ht.h....p....hh.l....as.h.sh....hl......lh..hs..s.L.s..h.ls.............................ttts..Y...s..s.s.Gs.WC..Wl..ss.....c....h...................h....h...RLh..lpal...h.alh..hhs.hl.hl.Yshl.ahhl++pht..h...................................................................................	3	53	120	185
+11543	PF11711	Tim54		Inner membrane protein import complex subunit Tim54	Wood V, Coggill P	anon	Pfam-B_3533 (release 23.0)	Family	Mitochondrial function depends on the import of hundreds of different proteins synthesised in the cytosol. Protein import is a multi-step pathway which includes the binding of precursor proteins to surface receptors, translocation of the precursor across one or both mitochondrial membranes, and folding and assembly of the imported protein inside the mitochondrion. Most precursor proteins carry amino-terminal targeting signals, called pre-sequences, and are imported into mitochondria via import complexes located in both the outer and the inner membrane (IM). The IM complex, TIM, is made up of at least two proteins which mediate translocation of proteins into the matrix by removing their signal peptide and another pair of proteins, Tim54 and Tim22, that insert the polytopic proteins, that carry internal targetting information, into the inner membrane [1].	32.50	32.50	32.70	33.40	31.70	32.00	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.24	0.70	-5.87	17	146	2009-09-10 21:07:40	2008-10-03 14:14:01	3	5	135	0	114	155	0	370.20	34	85.84	CHANGED	NPAL+hhGl.Ps....h..+LPSRNWMIFaolsuuhsuulhYD+tEp+chppKWschVc+lucEthsssp....hsRKlTVFlAsPPs.DhLcsuhchF+cYVKPlLsAAuLDY-llptcRpG-IRAtlAERIRclRRcth......................................tspst.sh-c..sppccslhshRphhGlh.....................-.ssstGslsIGRtsaKEYlpGLHEGhLGPL-.P.........................tspsttssst...pss.............tt.t.c..tssp...ptp......-s.-ccpp...........ssstP.aIsss-YssssLsPph..................P.hh.pPshslPhPpllGFLNhPh+lYRFhs+RhhA--huccsAulV.ss.hRPap.ts.................................tphhpcEEp-W.Kp............V+ptcE.........KcpEWlp............-lVhDsRlssRM+hap	....................................................................NPAh+..hhGl.Ps.......h..+LPS....RNW..hIFholsuuhsuulhYD++cp++hpp+atchVtplucEsl.ss.sp............hPRKlTValusPPu.D.t.LcsuhcaF+cYVKPlLsAuuLDaEllpuc+pG-lRstlAp+IRchR+phtt..............................................................-.....ptpp....h.phR.ph.hGlh.....................................-..hstGslslGRtsaKEYlpGlHEGh..LGPLp.P............................................................t.s.t..............................................tt.t.p........t...tp....p.tt....pt.pccpp....................p.pp.s.stP..alpsspYsst.pls.sph..............................................................P..h...pPshslshPpllGFhs.hPhRlaRF.hs+RhhA-plucpssslVhss...hRPaptsst..............................................................................................................................................................tphhp.pEEp-.W.Ks..............Vcptp-............................+pppWhp..............lshDsRlsp+Mpha............................................................................................................................	0	32	64	97
+11544	PF11712	Vma12		Endoplasmic reticulum-based factor for assembly of V-ATPase	Wood V, Coggill P	anon	Pfam-B_2410 (release 23.0)	Family	The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterised member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localised to the endoplasmic reticulum [1].	25.50	25.50	25.90	25.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.75	0.71	-4.48	35	291	2009-01-15 18:05:59	2008-10-03 15:33:25	3	9	252	0	209	275	2	136.80	23	54.40	CHANGED	ppLLcuo..cl.alPs.s.psc.............................................osEahApht+L+tttcpccYp+hh........t................................st.t...sp.stthcpl+pQlssllNlllSVlusshulahhsp..h.............................shshssRlLLulhsullVhlAEVslYst.....Ylp+lccA+	..................................................................pLLcsocl.hlP.........s.c.............................................ssEhhAphp+L+tptppccYpchs+ssss.pp.........................................p...sp..s.pphcsl..+p...plhhlhNhllolhushhssahhsp.h.h................................hshssRlllulhsuhlVhlAElhlhst.hhpp.t...................................	0	66	110	171
+11545	PF11713	Peptidase_C80		Peptidase C80 family	Rawlings ND, Bateman A	anon	Rawlings ND	Domain	This family belongs to cysteine peptidase family C80.	19.70	19.70	19.70	20.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.92	0.71	-4.42	23	303	2012-10-03 02:24:44	2008-10-03 15:44:17	3	64	136	14	38	286	6	155.10	33	7.28	CHANGED	spastplIlQL..................psDslstcAAt....sLhuK+PssSlllQhss-......Gsh+slaus...............sstL.....sGpl+hQlVGHGcs....t.ssspLuGhsscpLAstl.....pphppthsssh......pPc..+IoLVGCshsus......ptpsuaspchhptlpsp.Gl........pssVSAppucVpV............-tpG+Kcsl	............................+achQlIlQh..................psDslst+.AAs....sLAuKHsp..sSlllQhDs-..........usaRlhYGs.....................sspL......sGK.lRWQlVGHG+s.........ptspspL.u.Ghss-pLAscL.....pphppttphss......pPc..+I..slVGCulsus..........spppuFupphhpthptp.uh........phslsu.ptcltl............stt.G++.h.h................................................................	0	18	28	35
+11546	PF11714	Inhibitor_I53		Thrombin inhibitor Madanin  	Rawlings ND, Bateman A	anon	Rawlings ND	Domain	Members of this family are the peptidase inhibitor madanin proteins. These proteins were isolated from tick saliva [1].	25.00	25.00	26.30	26.10	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.75	0.72	-4.00	3	5	2009-01-15 18:05:59	2008-10-03 16:12:31	3	1	2	0	0	5	0	78.20	59	98.99	CHANGED	MKHFAILILAVVASAVVMAYPERDSAK.DGNQEQERALhVKVQERoDs.DADYDEYDEDGTTPTPDPTAPTARPRLRGNQ	MKHFAILILAVVASAVVMAYPERDSAK.DGNQEKERALhVKVQERs-G.DADYDEYDpDuT..TPTPDPTAPTARPRLRtNQ....	0	0	0	0
+11547	PF11715	Nup160		Nucleoporin Nup120/160	Wood V, Coggill P	anon	Pfam-B_1841 (release 23.0)	Family	Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth [1]. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export [2]. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 subcomplex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 subcomplex, but rather that it regulates the association of the subcomplex with the NPC and other proteins [2].	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	547	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.63	0.70	-6.38	25	339	2012-10-05 17:30:43	2008-10-03 16:27:08	3	28	235	9	234	658	13	407.00	17	36.15	CHANGED	lslss....................tstsst.pssspsEcshtpchhsosu.....hhppshsRhlhWRhh.....ssscsLplpslslspsh.p..........sl+lpFspslh...ssslshs-ppsp......slhlhshssohplasLpltsshapp...............sshs-pshp-hspphsssshshptsthhsss........sssplhluhssGullclp+ps......pustapphphsstsh.ttlpshh.h........tttpht.ssssuhshss..htspsalh...slshcppL+lWslsotph....h..h............................st....tp.hphhhsssp.....sshhplh.....h.p.tpsstphhslhhus.psupFthaplp.ss....sss.hhps.hst........t.........slhshphp.hchs.sshclWsLW.cssssh.lpplphs.p................................tshpsshs.pssss.thhps.t..sDst.-palchlhpsu+aotpsl......cpALphapcsht.hpsps.s........sLpcclssslsuplphct..pt.h..........s.ppatptssppWp+FathstchccptpcPluLsl.sh....sss......shllpsssluhl..RsssshEpl	.....................................................................................................h.....................................................................h.hp..........tphltl....shtht..t........................................lphph.ts.h.....sh.h....tp.ttt...................hh.lhhhs.ps....h.hhhh.h....th..t.....................................th...t..p..p......shsh..s..hhh....................................s.t...hhls..h.t.....sGslhhl.p..h.......................s.hh......hhptt.h...t.lp..shh.h.........................tt....shshshsh..p..........p.p.s............a.........lh..............sls.sppL+hWshpstph...............................................................................................h.s..t....................t...h.h..........................................hh.hhh.h........t...tu.p.hhhhth..s................t..............................sl.t..t...t.....hp..........t............p.t.....p.....lasLW..p...s.pst...h..l..h.hph...t.p...................................................................................t.................t.............cs..phahp.lhts.sh..as.thl....................tpuL....hap.p...........................................ltpplh.slttph..p.p.............................tth.t...t.W.pahthh.php.thtts.h..ul.h..............th........................................hllhtt..huhh..h..t.h-................................................................................................................................................	1	67	116	193
+11548	PF11716	MDMPI_N		Mycothiol maleylpyruvate isomerase N-terminal domain	Bateman A	anon	Bateman A	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.85	0.71	-3.75	100	2030	2012-10-02 14:44:17	2008-10-08 12:55:26	3	16	384	2	776	2315	367	128.60	18	55.18	CHANGED	ltsttpplsshlssLs.csp..hssPos.ssGWTltclluH...lststphhsth.............................h....ts...sh.t...........................stthpttsstssssllsthcpstsphtsshtshsspthhhhh....hssts......hhttphhEshlHthDls	..........................................................h.....tthsshlssls..ss..p.......h...s.s...P.....os..s...s.G..........W..........o..........lpcllsH.....ls.t.s...t.....p..hht..s.h..........................................h...........ts.............................................................................ttthp..t..t..s..s..h..s.s.s..p..l...h......st..hp.p...s..h..t...t...h.......h..t.t....h.....tt..h...........s...t..t.....................h.............s..h.........s..........hhhhhhh-hhhHt.Dl..................................................................................................................................	0	295	606	732
+11549	PF11717	Tudor-knot		RNA binding activity-knot of a chromodomain 	Wood V, Coggill P	anon	Pfam-B_4165 (release 22.0)	Family	This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.87	0.72	-4.26	56	1173	2012-10-02 16:56:36	2008-10-08 14:59:09	3	25	331	25	766	1153	19	57.70	30	10.62	CHANGED	ltlGs....+lhsp+..............csph+hAcIlpt+h.....ppsp.....................hcYYVHYhsaN+RLDEWVstcRlsh	.............................................................................h...Gp..+lhshc...........sshhacAcllp.hc..........ppsp.....................................................hpYa.VHYh.GaN.+R..........hDEWVstsRl..h......	0	255	376	601
+11550	PF11718	CPSF73-100_C		Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term	Wood V, Coggill P	anon	Pfam-B_2254 (release 23.0)	Domain	This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins. The exact function of this domain is not known.	19.90	19.90	21.50	21.50	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.29	0.70	-4.98	35	365	2009-01-15 18:05:59	2008-10-08 15:00:35	3	12	290	0	246	354	0	216.70	26	31.03	CHANGED	cGp..hl...SGlLVpps..FshpLluPsDL+E.YosLoToslsp+Qslplsus.h-LlpatLcphF.G....tl-.lsccc......................................thlVMsslslhhcppp........lplEWpu.NhhNDslADoVhAlLlsl-SSPAuVKtouppp..p.............................ptp.s.ppphcplhhhLcspFGss.hs.hppsc.....................hhlphspppuslsh......pshss.-sp.......scsLcpclpshlpRhpphstPl	.....................................................................................................sp.hlSG.l.L.Vpcs..Fshp.lhuPpDLpp..YosLsso...slp.......Q+Qslshsus....hs..L...lp..a..tLppha.G....slEplpppc...................................................................................................t.shhVh.t........s.lslphpsst...........lhlEWtu.s.hNDhlADuVhslllplpus.PtssKtssp...t...t........................................................................................t.tp.....p.p.....hhcpl.hhLps.FGcs..h..htpsp.......................................................................................................h.lpl.stppAplsh.................pshpl...csp........spsLcphlp.hhp+hhphhhP............................................................................................................................	0	86	140	205
+11551	PF11719	Drc1-Sld2		DNA replication and checkpoint protein	Wood V. Coggill P	anon	Pfam-B_1966 (release 23.0)	Family	Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent relicensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5 [1]. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication [2].	28.00	28.00	28.20	29.10	27.80	27.90	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.87	0.70	-5.39	23	196	2009-09-11 16:31:55	2008-10-08 17:09:09	3	11	170	1	145	183	0	323.50	21	46.24	CHANGED	hspL+sELKpWE+sFtspN.GRcPsRsDIKpsPEIutKYKpYscLKs..supts..............pspKRcp...............sh....psspTPpKs.............................t.p...t....p....ps.................shcstlGPTPQtsGKsLuLF.Dhh.ps.t......................ssuoPoss+hsospssss...........................pTPoKpctsh...............tt.tsptc.ssp...tcTPhssscchhlst.h........p...............................................hpTPsaL+R..............pp.sh.s.t.................................hSPpPl+..p+.hs....KuLSplsp.....Ec-plc--h-lLcEhEsEpt.................................p.tppphsDspss..................................................tsp.spshKKK..sQKRoTR+V+M+Psh.tcspspsphspsDhccE...........h..................................................................shhcpcsho-hhsph...t.p..sppcctpcscsptcpp.............tpspt.+K.............lpssup...Na+RLKlps+..tptp..hpuRa.pRR	......................h.tpl+hcLKpWE+sFtppp.GR+Ps+pDI.K.p.s.s.c.ltthYKp.Ypp....L+p..ttps...............................................t.pctpt..............................s.psPtpt......................................................................................hss..s.........................................................................................................os.p.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	39	70	114
+11552	PF11720	Inhibitor_I78		Peptidase inhibitor I78 family	Bateman A, Rawlings ND	anon	Bateman A	Family	This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.87	0.72	-4.24	8	389	2012-10-01 19:32:51	2008-10-13 17:23:26	3	4	345	0	161	477	26	62.50	29	58.57	CHANGED	CsApshQsLVGQPhssspssph.....spslRVl+PGDhlTMDYpssRLNlhlDtsssIosl+CG	........................C.st.hpthlGp.s..h...os...t.h.p..ph..........hsptsR..llp...P..G...sh.lTMD.......apscRLNlplD.s.s.spl.pplpCG..........	0	32	86	132
+11553	PF11721	Malectin		Di-glucose binding within endoplasmic reticulum	Finn R, Coggill P	anon	Pfam-B_783 (release 23.0) pdb_2jwp	Domain	Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186.  NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan [1].	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.30	0.71	-4.49	62	826	2012-10-01 23:47:32	2008-10-15 13:30:42	3	160	245	3	487	1418	44	162.90	26	22.05	CHANGED	hshtlNsGGsph....tsssGhhYpsDpt..suss..ph..t................................ht.stshhtspsp.....pLYpotRh.......us..o..hpYhh...........hlpsGs..YslpL+FAElhass......tthGcRlFDlhlpu.phllcsaDIhp..cusGhs.tsshcpa.ss.sl.ssstLp.......Iphhhhtpsp..l....ushs.Ph.IuAI	.................................................................................htlNsGutth........s.ts...h...hapsDt.....ssst.......h..t...........................................htp.st.th..s.stss.......tL..apTt...Rh..........u.t...o.....hp.Y..hh................h..ht..sG..s...YsV.........pLpFAElhass................tthGp.........R..l.........FDlhl...p.........G..p.............h.....lhc-...h...D..I.....hp.......psG.....uts......sshcp.h.....ss..sV..ss.s.t.Lp.......lc.hh......ht..st........uhhs.PhlsAl....................................................	0	154	331	413
+11554	PF11722	zf-TRM13_CCCH		CCCH zinc finger in TRM13 protein	Andreeva A, Bateman A	anon	Andreeva A	Domain	This domain is found at the N-terminus of TRM13 methyltransferase proteins. It is presumed to be a zinc binding domain.	20.90	20.90	20.90	22.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.61	0.72	-4.57	27	181	2009-01-15 18:05:59	2008-10-20 16:55:17	3	11	158	0	116	172	2	30.90	40	6.89	CHANGED	thpCpaal.+K+.R....hC+Mtt.ttGspaCspHts	........pCpaalt.+K+.R....aC+Mss..tsGp...paCGEHt....	0	38	62	97
+11555	PF11723	Aromatic_hydrox		Homotrimeric ring hydroxylase	Radauer C, Mistry J	anon	Pfam-B_24837 (release 22.0)	Domain	This domain is found on aromatic hydroxylating enzymes such as 2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas putida and carbazole 1,9a-dioxygenase from Janthinobacterium. These enzymes are homotrimers and are distantly related to the typical oxygenase [2].  This domain is found C terminal to the Rieske domain which binds an iron-sulphur cluster.	20.50	20.50	20.60	20.90	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.59	0.70	-5.07	7	55	2012-10-02 19:24:03	2008-11-07 17:10:43	3	3	44	49	16	58	6	216.30	38	59.09	CHANGED	aVGDu-...PsPLtcDlPPs............FLD-Dhtlh.G.+RhlpuNWRLulENGFDsGHlaIHpsS.hVhusDhAlPLGF..tP.uDcsth..shs-s.suPKGlhchh......scHh.PlFEusl.GpsshtGphh..pthVu...............lplSlWLPGVLKV-sFP.PshhpaEaYVPIDEsoa.YaphLu+hssocE-tcsFcsEa.cpcW+chAlpsFNDDDlhAR-uMpsFYusDpGWscEhLapsDtsIltWR+LsSp+sRGIQ	......................alGDt-....PPPLscDlPsp..................hLD-shslh.GhpchltuNWRlusENGFDsuH.l.alH+sShllcspDhsLPLG..h..hP..sspst...ts..-t..stPKGlhshh......s-phhP.lh-shh.G..shtss.t.....hhs...............hp....hSlWLPGVL+VpsaPtPchsQaEaY.VPID-spH.Yaphls+hssscc-tpsFctca....cpt...ahsh...sLpGFNssDlaAREuhpsFYs-spGWspE.LhcsDhuIltWR+LAScasRGI........................	0	7	13	15
+11556	PF11724	YvbH_ext		YvbH-like oligomerisation region	Bateman A	anon	Bateman A	Family	This region is found at the C-terminus of a group of bacterial PH domains. This region is composed of a helical hairpin that appears to mediate oligomerisation based on the known structure. This elaboration of the bacterial PH domain is only found in Bacillales.	21.50	21.50	22.50	26.10	20.10	21.40	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.92	0.72	-4.29	7	123	2009-01-15 18:05:59	2008-11-09 20:00:03	3	2	123	6	16	66	0	60.40	65	30.21	CHANGED	-aAcpSLshAsslhsphR.t.csslsppFKchschAFsWLssshppashKDFG.VF-KYIpN	........QYAHKSLDMASNAFSR.ISNA.QVNLAEQFKEMNEIAFNWLVDTKKQYNVKDYGFVFEKFINN...	0	9	12	14
+11557	PF11725	AvrE		Pathogenicity factor	Mistry J, Coggill P	anon	Pfam-B_735 (release 23.0)	Family	This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system [1]. The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas [2].	18.10	18.10	19.80	19.70	17.80	18.00	hmmbuild  -o /dev/null HMM SEED	1774	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.70	0.69	-14.34	0.69	-7.55	9	200	2009-01-15 18:05:59	2008-11-11 16:24:21	3	3	58	0	14	220	0	959.80	27	91.93	CHANGED	Mp....h.slspspsssltssssssssssssLpQ.pspsssQpuutSLsu.G.+shtphsplpQ..........pspussppsAs.....................sPps.ss.tts......tt.phtp.ht...p....p...st....p.t.........................................ph.ts.lsp.u................t.Phsptpssssshstpt.ssst.ts.stssQpsssuc.ct.pppthttpcsssPt...........t.hpstLstss...tuphchpspph.pshpspss............IoLDscGK.pFushpsPAlssLLcppLGKssQsYLAHpusssup....pHhLL-spGHLhcltps-suhull+SSpssshh...utscsssVpLppcssplpls...pupspts.sLPGcAHhAhLoGl.......phsssG-plRlHDDKlaphss.huhWp...ssc-ssaSpLospGDGplYA.+sscsLsNLSSsp..hschhlcclpSFSVu.cGpVAlLospDops.pLs.Mssl.us.ts+hphoLcLss.......Gcu..pApuVuLos-RLFlADo-G+LYSAsRsphcss.-s.LchhPpps.....spthGtccploGFhosDcGQlpALlKsp.GphHupsLs.pssphcsGWNLoDuLVl-NphGLssh.sPssccpLsLsRtGplGLp-G+lphaDusTcsWc-Aul.DhcpLpRGhDusAYlLK-Gcl+cLsls.cpsshsaucssshA.sthpsKsEhGsAlpGL-.scslpAhAhlusppFlALDDpGclpuHp.KsGp......PhsLo+cGLsG-lKslsLDccpNLaAlTpsGcLFphsREsWQssc.us.....................................................upWptlshP.sppslcuLtssscpplssplcD.......uhhpL+utpWpshps+.....sstpsuhpslFsRLspuhKshpIPGTGlTl+hssphhG+oGhEppp.+SphuEhlRAalapsThpsPRPhKNsu.plQHRapGR-GLptVYchpuhLhKQL-...pssupssssupDLpo+lspLD..LG.cGtpLlc-LcpFR-ELEspuppAlhhlG..........QppGVLNppGplscptK.....tt.tthspthNhppSG+DLsKtLpsAlppsuPSspssstpLLpphhssGlchSHpKuDhPhGppRDssDcpuLoKuRLsLDlVTLs-LtcLlDKAchlospss..stlppLcpcLssLR-ppYG-NPVKphTDMGFTcNtALEusYDuVKuFlNAF+KtcHAVSVshRsshtopsQu-LAcKhKssLhpL-pG.-pIuhoRSYGssLoTsFlsh..schsssshPuAGhTssRNYsLshpRs-GGlsVhhhR-GusssosuVuuG+DlhPhhsscspsAc..Ss.lusc++hsPshRlGusloushptoppsulsFsls---lsuFlDsLhpGpLsPLplLcKGh-Hps+pu++hsFslssuuss-LRsGlslo-.......ssScPhoAssRsusGhssosNLhohoctp.TQcs-pophppuScNRPRFhNssshGAphpsplusuHss.pts.............sootst.psGo.sAhssssVssslulDsRTspplphchKpApPlTspslscLopoLGcsFKDsAopthLucLtc.psuc.....Pc-....pLcuLpchFus+sspsDcQYcALRsLK+hsscpcAu.scpusLDsARapTsYTNLS+LsppulhshIhsplpuAhsPoNAsRluchMspDPtLKullKphQuSsuT.ApVpLE.KDsLhD+l-cG.h-GplspcElusLhpDRNNhRI+ulsV.posspoEGFsoPTsLlSsssSAulShsKsLGpINFhYGpDQ-pPpuaTl-GElu+ssssltsAhscLKK-GhEhKS	........................................................................................................hh.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sth.............t..tt.hp..tttla.hp........Wt.......t..t..hs.l.hthpGphh..psst.h.p.ss...............h..s..stssh..t..............................................................t..........h.thsh...t.t..p..lhhhstpsthh.h........................................................................h.hsh.........s.......t.t.pstWphpp..hh..p.Gh........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	4	8
+11558	PF11726	DUF3296		Protein of unknown function (DUF3296)	Mistry J, Coggill P	anon	Pfam-B_768 (release 23.0)	Family	This family is expressed in Gammaproteobacteria. One of the E coli members is annotated as yagK, but otherwise the function is not known.	22.30	22.30	22.30	23.00	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.31	0.71	-4.71	36	1241	2009-01-15 18:05:59	2008-11-11 16:48:00	3	3	492	0	89	791	27	153.40	27	81.94	CHANGED	ppltpslcpslscasRlhslRlDL+hPp..ph.sp.....s..........sslocFhpsLcsplptp.................phhpspltYlWs+Epsp.ss..phHYHlsLhlN.p.a.t.Gphppps.slsspIppAWtpuht.hth....cspsllphs....cps.....tYhls...htpts.ppshc..slhhRlSYLAK..tcoKph.spt..t+sFGsSp	.........................................hpphlpthhp.as+......lhshRlDlth.c....s.ssh......st...........................tsls..phhptLps......clp......................p.h.shltYhWshEasp..pt..thHhHhhlhls...............Gph.p.t..........s.........pl..uthIppsWp.psht.....sh..........phtshsp.hs...tps......................................thhlp..............t.s.stpshp..pl.h...p.h.sYLAK......tc..s....Kth...s......psaGpS....................................	0	20	37	61
+11559	PF11727	ISG65-75		Invariant surface glycoprotein	Mistry J, Coggill P	anon	Pfam-B_785 (release 23.0)	Family	This family is found in Trypanosome species, and appears to be one of two invariant surface glycoproteins, ISG65 and ISG75. that are found in the mammalian stage of the parasitic protozoan. the sequence suggests the two families are polypeptides with N-terminal signal sequences, hydrophilic extracellular domains, single trans-membrane alpha-helices and short cytoplasmic domains. they are both expressed in the bloodstream form but not in the midgut stage. Both polypeptides are distributed over the entire surface of the parasite [1,2].	22.70	22.70	22.80	23.80	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.08	0.70	-5.35	20	223	2009-01-15 18:05:59	2008-11-11 17:19:18	3	4	11	0	71	209	0	254.70	29	57.37	CHANGED	thlhhhhssllhhslshApttph.......pus+KLsp-GApuLCph+cLucpV.scpuDplhccspphsstlptthcplp.hhpplt............c.s-ucpccl+phhpcAKpclpctltp.ucphsccsccptpclKcAApcAht.t.p..tt.pSsGLpcVLsWaCtsp....scst..s..spNC.-slshppch......ssst+ssIsC....sttspss.hpssosssMcpAl-pWspsKP.......K.....c.t.psssstCpp.ts.stspPCTlhEp.WpscYcsuhpclccLEcstcpuppstct	.....................................hshhlhsshhslslshupp.s.hs.t.......hss+pLstpuAtsLCpMK+Ll-sV.sspsDph.c.ppshpa.l.ssspt.thp+l..............................S-pcphpsshsps..+hpthpthpp.usphhctht...cptccAKpAAssA..................Ss.u.LpclLcWHChsc....tcs..t.s...ssNC.-sssa+cca........cspphsI....C....phpshssspspsThu.sMctAL-tWsps.KP..........K........hph...susstssp.pusssscPCTlhEs.WhhsYcsstphltcLEpshp.uhtshc.h.............................	0	45	71	71
+11560	PF11728	DUF939_C		DUF939 C-terminal domain	Bateman A	anon	Bateman A	Domain	This region is a presumed intracellular domain found in a set of bacterial presumed transporter proteins. The region is about 160 amino acids in length.	21.50	21.50	21.60	21.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.95	0.71	-4.44	30	916	2009-01-15 18:05:59	2008-11-13 17:09:13	3	3	912	2	73	425	1	166.60	34	52.19	CHANGED	h-cclccapppIEpph+pILhchuthLpssctp..hpstplscLcphlccA+slAa+chcNph.h+pcshYh+YF-MRcpQh-lLc+MhsplsslphsscQsphlAchhcclusslppsNsuphhLccLpch+cpFcchsLPpTREEFEsRAsLaQhLp-hEpaLhlKsp	........-cclccY+pplEpph+cILpchs.aLpptps.........c....sp........u.......t.htcLcph....lccAppluap-hcNa.h.h+.....p.s......sYah+...YF-.MRp..pQsclLcpMtt.lsslphss...pputhlApLhpclut....slspsNsusphLcc.l.pchhpha+ph.sLPpTRcEFEsRAsLlQlLpEhcpalplKs.....	0	25	44	59
+11561	PF11729	Capsid-VNN		nodavirus capsid protein 	Mistry J, Coggill P	anon	Pfam-B_805 (release 23.0)	Family	The capsid or coat protein of this family is expressed in Nodaviridae, that are ssRNA positive-strand viruses, with no DNA stage. These viruses are the causative agents of viral nervous necrosis in marine fish.	35.30	35.30	35.30	92.30	35.20	35.00	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.16	0.70	-5.48	3	443	2012-10-04 01:49:40	2008-11-17 14:19:14	3	1	133	0	0	217	0	193.10	74	99.75	CHANGED	MVRKG-KKLAKsATTKAANPQPRR..RsNNRRRsoRsDAPVuKASTVTGFGRsTNDVHL.SGMSRIuQAVLPAGTGTDGaVVlDpIIVP-LLPRLGHAARIFQRYtV-TLEFEIQPMCPANTGGGYVAGFLPDPT....DuDHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSoGKEQRLTSPGRlILLCVGNNTDVVNVSVLCRWSVRLSVPSLEpP.EplAsPILTQGsLYNDSLostYN...................HFcSlLLGSTPIDlAPTGTIF.QLDRPLpIDYSLGTGDVDRAsYWHF+KhuGNls+PAGYhpWGlWDuFN+TFTsGlSYYSDsQPRQILLPV......GTlpsRhDSEN	...............................................................................................................................ANTGGGYVAGFLPDPT....DNDHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSo...GKE.QRLTSPGRLlLLCVGsNTDVVNVSVhCRWSVRLSVPS.LETP.E-TTAPIhTQGsLYNDSLuT..N...................DFKSILLGSTsLDIAPDGAVF.QLDRPLSIDYSLGTGDVDRAVYWHLKKFAGsAuTPAGWF+................................................................................	0	0	0	0
+11562	PF11730	DUF3297		Protein of unknown function (DUF3297)	Mistry J, Coggill P	anon	Pfam-B_797 (release 23.0)	Family	This family is expressed in Proteobacteria and Actinobacteria. The function is not known.	19.10	19.10	19.10	100.60	17.40	19.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.18	0.72	-4.29	30	320	2009-01-15 18:05:59	2008-11-17 14:20:50	3	1	318	0	106	230	31	70.90	61	82.61	CHANGED	PDRLSssPcSPaass-lLpRslGIRFpGpE+TsVEEYClSEGWVRVsAGKAhDR+GpPhTIKL+GsVEsaa	.PDRLSsNPRSPaastEsh-+..sIGIRFNGcERoDVEEYCISEGWlKlsusKAhDR+GNPhhlpLKGsVEAaY.	1	15	52	79
+11563	PF11731	Cdd1		Pathogenicity locus	Mistry J, Coggill P	anon	Pfam-B_826 (release 23.0)	Family	Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria [1]. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.	25.50	25.50	25.50	25.70	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.91	0.72	-4.06	25	195	2012-10-03 02:11:09	2008-11-17 14:34:06	3	3	188	0	48	189	25	90.70	35	88.25	CHANGED	M..........s+s.scs..................................thpcLpcLPNlGcAsApDLphLGIppsppLtGccPhchYpcLschoGpppDPCVlDVFhulspFhpGp..-....spPWWpaTcERKpt	...................................................................................ppLpcLPslGcuhstDLp.hlGIcplssL+GcsPh-lYcch...Cphp.G...pphDPClL.latssVhahpspp......hp.WWpap-cp+t.............................	0	20	33	40
+11564	PF11732	Thoc2		Transcription- and export-related complex subunit	Mistry J, Coggill P	anon	Pfam-B_819 (release 23.0)	Family	The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats [1]. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex [2].	20.40	20.40	22.10	24.10	19.10	20.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.41	0.72	-4.19	22	297	2009-01-15 18:05:59	2008-11-17 15:09:49	3	5	248	0	207	292	3	75.90	44	4.48	CHANGED	luKlsasNPhhshpshLpQIcsYDNlhphVV-ssKYhosLuaDlLsasllppLs.ssRsphppDG.hs.uhWlpuLus	...luKluauNPsllhch....lLsQIpsYDNLIssVV-.sh.KYh.TsLsYDVLsa..........sl..lpuLu....p.s......p.....+p+hpcDs.hshSpWLQuLAo...............	1	67	114	171
+11565	PF11733	NP1-WLL		Non-capsid protein NP1	Mistry J, Coggill P	anon	Pfam-B_837 (release 23.0)	Family	This family is the non-capsid protein NP1 of the ssDNA, Parvovirinae virus Bocavirus of cattle and humans.	25.00	25.00	96.70	96.00	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.32	0.72	-3.73	3	376	2009-01-15 18:05:59	2008-11-17 17:06:10	3	1	14	0	0	133	0	93.50	90	83.10	CHANGED	MSScsTKD+HRSpKRpsSPhR-ERKRsWc.p++SRSRSPIRR+GE+ShGSaRppsQ-s+QSSsTASKsSDpATKTKEsTSG..sTRTNPYTVFSQHR	MSSGNMKDKHRSYKRKGSPERGERKRHWQTTHHRSRSRSPIRHSGERGSGSYHQEHPISHLSSCTASKTSDQVMKTRESTSGKKDNRTNPYoVFSpH.....	0	0	0	0
+11566	PF11734	TilS_C		TilS substrate C-terminal domain	Sammut SJ, Bateman A	anon	pdb_1ni5	Domain	This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.	21.00	21.00	21.10	21.10	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.34	0.72	-4.75	140	2601	2012-10-01 21:04:40	2008-11-18 16:14:21	3	9	2576	4	480	1909	354	70.80	26	16.01	CHANGED	lp.lRh+...tuGpchp...hs....+stsRpLK+laQEhslPsWhRs+lPLlah....s-.pL.lsss.Glhlspt.....h.s...........ttt..h....plp...W	................lplRh+...psG-hhph..hG....pssp.+KLK+la.-tplP.ht.R.c.phPl.lh........s.p..pl..lsl....s..Glhhspt.....h.................................................	0	178	312	403
+11567	PF11735	CAP59_mtransfer		Cryptococcal mannosyltransferase 1 	Mistry J, Coggill P	anon	Pfam-B_916 (release 23.0)	Family	The capsule of pathogenic fungi is a complex polysaccharide whose formation is determined by a number of enzymes including, most importantly, alpha-1,3-mannosyltransferase 1, EC:2.4.1.- [1].	25.00	25.00	25.00	25.00	24.70	24.20	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.54	0.70	-5.15	37	382	2009-09-11 16:30:58	2008-11-19 09:33:18	3	7	108	0	245	384	4	212.70	30	50.86	CHANGED	+lFIAhsLa.pstplltstastull....pLhchLGs.....-NVFlSIYEssSsDsopssLp.tLc..LcplslppsIhh..s.tschs..th......................h+RIsaL.............AclRNhALcPL.p....................ttpshtaD+lLaLNDVhFsspDllpLLhsss.................sp..........................................YstsCulDF...sp..s.pF.................YDoassRDhp.Gpth............shshaPaFpss....sspcshstppsl.VpSCW.........sGhsuhcAp.Fhtsp.........................slRFRu....sth....h-uSECsL....IpsDh.....ss	...............................+hahAhsla.pstpll.shhu.sllplhphLG.........................cN.lalS.lhEss.SsDpotshLp..hc..hp.....phsh.ph.lhh.......ppht........................................cRItaLAplRNtAlpP.L.p........................................t.t.s.ta...cpllF..lN.Dlh..hsst..DhlpLlhppp....................tp..........................................................hthsCu..hDa..............t..s.hF.........................................................YDsashRDhp.G.th.......................h.has..hh....t.st.............tppphh...t.t.sh.VhuCW.........sGhsshsst.h.....................................................................lpFRt.....t.......h.tuEspLhh.D.....s.......................................	0	69	141	197
+11568	PF11736	DUF3299		Protein of unknown function (DUF3299)	Mistry J, Coggill P	anon	Pfam-B_876 (release 23.0)	Family	This is a family of bacterial proteins of unknown function.	21.20	21.20	21.30	21.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.30	61	436	2009-01-15 18:05:59	2008-11-19 10:02:20	3	3	323	0	135	407	201	144.10	36	78.53	CHANGED	lsWp-Lh.P..ts.s................t.hspltsts.................thpps.sth.......................................pp.hsuslsppLsGptV+lPGalVPL-.sssttlTEFLLVPYaGACIHVPPPPPNQIVaVphscG.htlps.........LasPlWVpGpLpscphss.-lA........psuYshpusplpsY....c	.................................................................sW.-Lh.Pts..p.....h....................p.ts.s.................h.ppt..th.......................................p...suslsppLsGp..pV+lPGallPLE.....s-psplTEFLLV..P.YaGAC.IHVPPPPPNQIlaV+hs.cG...ht.lp.p.........las.slaVpGpL+scph.ss..-LA........psuYphpusplt.Y......................	0	38	74	105
+11569	PF11737	DUF3300		Protein of unknown function (DUF3300)	Mistry J, Coggill P	anon	Pfam-B_886 (release 23.0)	Family	This hypothetical bacterial gene product has a long hydrophobic segment and is thus likely to be a membrane protein.	25.00	25.00	26.80	30.50	20.70	24.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.72	0.70	-5.10	71	636	2009-01-15 18:05:59	2008-11-19 10:38:50	3	1	598	0	129	443	35	275.10	57	50.70	CHANGED	hopupL-QhlAPIALYPDsLLoQlLhASTYPL-VVpAsRW...psNspLpG-.........shhpAlpsps....WDPSVKuLlAFPplLphMu-clsWTppLGDAFLuQpp-VMsulQpLRppAppsGsLposppQpVsppp.ps...................................IhIEPAsPpVVYVPhYsPslVYG.sW.a.ssYP..Ph.Ya......s.Psh..........sshs..suhuaus.Glsl.uhsh.......a...uu.......hc..Wssc.....................................plslshpphpphstp...........sstpWp..Hs	....FSTAQIDQWVAPVALYPDuLLSQVLMASTYPsNVsQAVQW..S+..D..NPhhQGD.........AAIQAVu..sQP....WDsSVKSLVAFPQLMALMGENPQWVQNLGDAFLAQPQDVMDoVQRLRp..LAQQTGSLKSospQKVlossKpsssst.ssssss...........sshstsssTVIsIEPANP-VVYlPNYNPsVVYG.sW..sN....TAY..P..PV.YL......PPPsGpsF......sDSFV+GFGYSh.GV..ATTYAL......F...SS........ID....WDDDDHcHHccDpcs.t...............htpsussapHNGDNINIsVNNFNRIoGppLsspshs.........W...pss.....................................................................................................................	0	28	54	94
+11570	PF11738	DUF3298		Protein of unknown function (DUF3298)	Mistry J, Coggill P	anon	Pfam-B_854 (release 23.0)	Domain	This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.83	0.72	-3.47	347	1368	2009-11-03 10:59:44	2008-11-19 11:12:14	3	22	951	4	301	1129	32	88.50	19	30.96	CHANGED	LpD.........l.hps..t.................hhptl......pphlppph.......t.....................pptt..t.................................ptht.shtt.......................................spsah..lssc......u.ls...lhas....Y-l....u........Pauh......G.hh....phplPhpp	................................................................................................................................................sl.hps...s............hhphl.pphlpppl....t.....................pp.pt..............................................................thh..tht....t................................spsFh......lssc........u.ll...lhas.YElu............Pauh...............G.hsphtlPht................................	0	106	205	258
+11571	PF11739	DctA-YdbH		Dicarboxylate transport	Mistry J, Coggill P	anon	Pfam-B_935 (release 23.0)	Domain	In certain bacterial families this protein is expressed from the ydbH gene, and there is a suggestion that this is a form of DctA or dicarboxylate transport protein. Dicarboxylate transport proteins are found in aerobic bacteria which grow on succinate or other C4-dicarboxylates [1].	23.00	23.00	23.10	25.50	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-10.98	0.70	-4.88	59	772	2009-01-15 18:05:59	2008-11-19 11:34:00	3	4	734	0	150	542	34	200.70	45	24.22	CHANGED	lplsplss.Glslsshphphphphst..........t.lplp.................................ssssshhuG.pltlsphshsh.pst..pshlplpslsLscllpl.shpsltuoGplsGslPlhlsss.thplpsGpLsucss.Gplphsssss..cshu..tss.shphshssLcshcYspLsuslshsssGchhlslplcGpN.....ss...........htsspPlplNhshc-NlhpLh+SLphu..splpptlc	............................................LRIAplhN.h.lss+NITADLQGpYPa...................oEppPLhLo....................................-VSlDVL.GGpl.hhcpLRhPQ.HD......PAlL..RLpNlSuSEL..loAl..s.P..KQ..FAMSGshSGuLPLWLNNc.KWll+DGWLsNsGP..h..TLRlDKDsA...DA....ls...............+s................N.h...oA...GsAI....s....WLRYMEIo+SpTcI.NlDNLGh.LThpAsIsGpS.+s........................csKsssVNLNYpHEENlFsLWRSLRFG..DNLQsWLE.........................................................................................	0	31	66	113
+11572	PF11740	KfrA_N		Plasmid replication region DNA-binding N-term	Mistry J, Coggill P	anon	Pfam-B_844 (release 23.0)	Family	The broad host-range plasmid RK2 is able to replicate in and be inherited in a stable manner in diverse Gram-negative bacterial species. It encodes a number of co-ordinately regulated operons including a central control korF1 operon that represses the kfrA operon. The KfrA polypeptide is a site-specific DNA-binding protein whose operator overlaps the kfrA promoter. The N-terminus, containing an helix-turn-helix motif, is essential for function. Downstream from this family is an extended coiled-coil domain containing a heptad repeat segment which is probably responsible for formation of multimers, and may provide an example of a bridge to host structures required for plasmid partitioning [2].	24.10	24.10	24.30	24.30	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.43	0.71	-3.66	107	609	2009-01-15 18:05:59	2008-11-19 13:15:57	3	4	377	0	187	552	51	116.60	23	36.79	CHANGED	lsppplhpA.ustLhspGp.......pP...........TlcsVRptlG......pGShsTlsphLccacppptsts.........stst...hP.ssltpshsphhtplhppApptAppplpptcpphptpttphptptppttpphpphppphpp	.................thpplhpA.sptLh.st.Gp.......pP.................ospsVRptlG.......sGShosl..sphlccapppppsts.................tss...lP.tsltp.....thsphhstLhpp...........Ap...p...tA....ppt..........lstt.c..........p....t...hptph...tp...hpp.phppt...ttphpphptpht.t.........................................................	0	27	74	132
+11573	PF11741	AMIN		AMIN domain	Finn RD, Coggill P	anon	Pfam-B_11438 (release 23.0)	Family	This N-terminal domain of various bacterial protein families is crucial for the targetting of periplasmic or extracellular proteins to specific regions of the bacterial envelope. AMIN is derived from the N-terminal domain of AmiC, an N-acetylmuramoyl-l-alanine amidase of Escherichia coli which localises to the septal ring during division and plays a key role in the separation of daughter cells.  The AMIN domain is present in several protein families besides amidases suggesting that AMIN may represent a general targetting determinant involved in the localisation of periplasmic protein complexes [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.31	0.72	-4.03	172	2653	2009-01-15 18:05:59	2008-11-19 13:52:53	3	59	1806	0	715	2042	505	99.40	24	20.71	CHANGED	lclhss..ttth.clhlpos.tshphpshtl......ssPsRlVlDltssphshshp.........phpsssss...lpplc.ssp...pssssRlVlcl.ct...ssps........h..tppsptlllsl	...................................s...sp.s..+lslcts..p.....h...p....h.ptFsL.......ss.P.s..Rl.V.l...Dlpssshssshp.....................phph.s...ssh...........lppl..R..suph.......sss...s.sRlVl-L.cp.........ssps..........ss..tt.tpplhhs....................................................	0	182	458	606
+11574	PF11742	DUF3302		Protein of unknown function (DUF3302)	Mistry J, Coggill P	anon	Pfam-B_953 (release 23.0)	Family	This family of unknown function is expressed by proteobacteria.	21.00	21.00	21.00	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.85	0.72	-4.13	8	755	2009-01-15 18:05:59	2008-11-19 18:01:27	3	1	490	0	69	251	11	74.40	78	65.64	CHANGED	LDYFALGlLlFVslVlFYGlIlIHDIPYEIAK+RNHPHQDAIHVAGWVSLFTLHsIWPFLWIWATLY+P-RGWGhssh	.........LsYFALGVLIF.VFLV.IFY...G...I..IhlHDIPYLIAKKRNHPHADAIHsAGWVSLFT.LHVI.WPFLWIWATLYpPERGWGMQs.t...............	0	8	18	42
+11575	PF11743	DUF3301		Protein of unknown function (DUF3301)	Mistry J, Coggill P	anon	Pfam-B_952 (release 23.0)	Family	This family is conserved in Proteobacteria, but the function is not known.	25.00	25.00	39.00	47.80	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.07	0.72	-4.46	55	323	2009-01-15 18:05:59	2008-11-19 18:02:21	3	1	323	0	92	257	40	94.80	33	82.77	CHANGED	sLh...hlhll.shsshhaWpt+phpEhAhtts+ptCcchslQLL-tuhshp+hphtt...pGphphpppatFEF.SssG-sRYpGplhhhGt+ltplcLssa	.....sLhlllhl.shsshhaWpt+phtEhAhthscppCpchclQLLs.uhst++l.phsh...sGphphpphYtFEF.SssG-spYpGplhMhGt+ltplplsPa....	0	26	52	73
+11576	PF11744	ALMT		Aluminium activated malate transporter	Bateman A	anon	Bateman A	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.26	0.70	-5.82	18	320	2012-10-02 19:04:43	2008-11-20 17:12:55	3	13	54	0	205	1758	29	327.50	31	66.11	CHANGED	achG...+cDPRRVlaulKVGlALoLVSllYahcs.acslGssAlWAlhTVVVVhEFSl................GATLsKGLNRuLGTLhAGuLAluhphlu.shoGc...hEsllluhslFlhuhhATah+haPthKs.Y-YGhhlFlLTFsllsVSuYRscph.lphAhpRhhpIslGuslClhlslhlhPIWAGEDLH+LlspNhpplupuLEG..........................CVspYhcshEh-........hps.s--slapGY+olLsSpupEEoL............hsFApWEPsHGta+.a+aPWppYlKlGuslR+CAaplhAL..........HGCl..poEIQuP....p-lRstF+csht+luhEuuKlL+-Lucsl+pMc+sos..p.llpcl+hAscpLpppI.cspshLhlsop..t........t..........................................................................st...p.................hcshE.upuLslATFASLLIEhVARL-sll-ul-ELu	.................................................................................utpDs++hhauhK..hGl..uL.s.L.l...S..hh..h.h.h...p..........h.p.t...h....u.......p..u.h..W.Al.h.T.V.V.VV.h...E..a...o..l...........................................GuTlsKGhNRuhuTlh.AGhl..u.hs.h.t..lu...th.s.Gp.......h.ps.h.l..l..s..h...l..F...l....h............uh...h.....so.......a.h.+..h..h.Pt.......h.K.......a.-...Y...G...h.h.l..F.lLT.a.s.....l......l....s...V.......S........u.....a..........p.........s......p........p...............h.........h...p....h..A.........h......p...R..h.............hI.slGsshslhlslhlhP..l....WA....G...p-....LH....p.ss...tshpt..l....Ap.l.-u............................................hsppY.hp.t.t.t..............................ttp..hhp..sa+...ss.lpSp..s.p.--sl.............hthA..hWEP..HG.at...hpaPW.p.pY.+..l..............us.hhRp.h..u......h.Ah.............tu.hl.......s.p....p....ss......php....h....htt.h.phu.p.supsLct.hu.t....lpphph........t.hh.th.t.Ah.ppLp..l.p...............................................................................................................................................................................................................t.h.hh.hs..l.ch...hp.l..th..h....................................................................................................................................................................................................................	1	50	144	177
+11577	PF11745	DUF3304		Protein of unknown function (DUF3304)	Mistry J, Coggill P	anon	Pfam-B_956 (release 23.0)	Family	This is a family of bacterial proteins of unknown function.	20.60	20.60	21.10	20.70	20.20	18.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.67	0.71	-3.89	44	431	2009-01-15 18:05:59	2008-11-24 11:52:26	3	5	195	0	98	376	5	114.60	29	62.93	CHANGED	sLuuCspst...................sshtuhs........lhuhNaTshsItpFhl..sGt......hGusshss.......huGGGGtsCChslPppW+.GhplpVcWp.......................ptphtp.p.tsphtptt.VslPphsth........sshlpV+FLPscclcl	........................................................................h...sssps............................sshsuss...lpshNahc.h..s..IhtFsV...sG..............tGusshu.........sGGGuhsCChsls.....GhsscVpWp......................................hpptphtt...thph...pp...pphs.lslPchpht........pshLpVHFhPsc+Vc..................	0	10	27	46
+11578	PF11746	DUF3303		Protein of unknown function (DUF3303)	Mistry J, Coggill P	anon	Pfam-B_958 (release 23.0)	Family	Several members are annotated as being LysM domain-like proteins, but these did not match any LysM domains reported in the literature.	21.10	21.10	21.40	21.90	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.92	0.72	-3.61	33	128	2009-01-15 18:05:59	2008-11-24 11:53:10	3	1	72	0	67	134	549	85.20	24	86.48	CHANGED	hallpapF.sspsp..s.pshtcahcsG..t.t-p..-GacllsRhHsPtsupGhslscA-sspslacahtsWpcthslph-lsPsloDpEhls	.....................halhphpF.stppp....pshtcahcsG.....tsh..-GhchltRhtssssupsahlscu-ssptlacaht.Wtch..hch.-lsPVlosp-hs....	1	7	33	49
+11579	PF11747	RebB		Killing trait	Mistry J, Coggill P	anon	Pfam-B_983 (release 23.0)	Family	RebB is one of three proteins necessary for the production of R- bodies, refractile inclusion bodies produced by a small number of bacterial species, essential for the expression of the killing trait of the endosymbiont bacteria that produce them for attack upon the host Paramecium. R-bodies are highly insoluble protein ribbons which coil into cylindrical structures in the cell and the genes for their synthesis and assembly are encoded on a plasmid. One of these three proteins is RebB.	18.80	18.80	19.50	20.70	16.40	17.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.23	0.72	-4.10	32	294	2009-01-15 18:05:59	2008-11-24 15:51:45	3	1	94	0	104	256	12	66.90	41	67.18	CHANGED	ITDuVT.QsNscVlGpAPAhAMGslaQusup.uh.....uluhpNAVsuQQptphhupAusspGVstlhohsosus	..............ITDuVT.QsNsKVlG.-APAhAhGsLYQuhup.uh.....uhshcNAs..suQQQtphhupAuostGltplhulssss.s..........	2	31	51	92
+11580	PF11748	DUF3306		Protein of unknown function (DUF3306)	Mistry J, Coggill P	anon	Pfam-B_984 (release 23.0)	Family	This family of proteobacterial species proteins has no known function.	25.00	25.00	42.50	41.60	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-3.43	58	273	2009-01-15 18:05:59	2008-11-24 16:08:42	3	3	268	0	74	236	87	114.20	32	54.64	CHANGED	uFluRWSR.RKtss..................ts-psst.t......................ssssstssssptsptsphsspchht...................sLsDs-sl.s.ssDhssFhsc.sVsppl+psALR+Lap.sPtassh.DGLs-Ys-Da.ossssls	.........FhSRWSp.RKhps..................ps-p.hpst.....................................s.sstss..s.ts.tspsshp.sppshp...................sL.ssscsl.stpsshusFlss..slspplK+AALRKLFh.sscFsth.DGLc-YstDYossssl.s........	0	13	36	54
+11581	PF11749	DUF3305		Protein of unknown function (DUF3305)	Mistry J, Coggill P	anon	Pfam-B_976 (release 23.0)	Family	Several members of this family are annotated as being molybdopterin-guanine dinucleotide biosynthesis protein A; however, this could not be confirmed. The family is found in proteobacteria.	25.00	25.00	26.40	31.60	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.91	0.71	-4.31	51	269	2009-01-15 18:05:59	2008-11-24 16:10:00	3	3	264	0	73	213	96	134.40	34	80.71	CHANGED	htluVlhc+ps....ssRWsshpWphsullP.......sts.......phLppc...st..pahhsshslcLa+s-spuYhhNLsupsPslaVlh+tspss................hpshhlTAS.t-Atsa....hDsG-p.V-plPMP.sltuWlpAFlspHa..E...hKR+...Rc	.......................htlhhpct.....suRWtshpWplpuhh.........................pshtps...p.......sshsLpLa+DEpssYRhNLoopsPpLFllhcpst-s..................hpsstlTAS.s.Aupa....hD.G-phV.sssMPhslpAWhcAFlscHt..E..th+RK+c....	0	12	35	53
+11582	PF11750	DUF3307		Protein of unknown function (DUF3307)	Mistry J, Coggill P	anon	Pfam-B_1017 (release 23.0)	Family	This family of bacterial proteins has no known function.	20.60	20.60	20.90	21.00	19.70	20.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.07	0.71	-4.40	37	380	2009-01-15 18:05:59	2008-11-24 16:32:56	3	1	364	0	129	369	88	125.40	23	62.06	CHANGED	hlllhLllAHlLuDFhhQspphlppKpp.....+sphLhhHhhIhhlhhhllhhhhth............hhhhlllsloHhlID...hhK.hh.pt......................shhhFllDQlhHlhl..llslhhhh..................h..h.hhhhh.phlhh	............hhhhLl.luHlluDFhl.Q........opphu.ctKpp..................pht.hLhhHhhl.hsls..hhll.h.h.h.h.s....................hhhhhll...hlo.HhlID.........hhKsthtpph.............................phhhF...l....l....DQhlHlls...lhhlhhhh............................hhhh.............................................	0	40	87	112
+11583	PF11751	DUF3308		Protein of unknown function (DUF3308)	Mistry J, Coggill B	anon	Pfam-B_993 (release 23.0)	Family	Some members of this family of bacterial proteins are annotated as being one of the several TonB-dependent siderophore receptors, but this could not be confirmed.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.76	0.70	-5.10	103	599	2012-10-03 17:14:37	2008-11-24 16:45:15	3	4	144	0	319	828	889	278.90	23	82.68	CHANGED	stuppcspaoQYhh.NhhhlNPAaAGspss.hplthhhRsQWsGl-......u..APpT.shohss.lsc..ps..............GlGlslhsDphGs...hspsshtssauYplpl....ucpsp...........L........oFGlpuGhh.hsl...chsphs..........sssDs.thtt.......sphhsslusGhhahs....c......paahGlSsssll....ppphspsstt.........sp.thpahhhuGYsFshs................phphcPuhhh+hstss....sh......plDlssphhhpt..............phhhG...suYR..................hs....pulushlGhphs.....shhlGYuYDhs..hss.lst..hssGoHElhlta	.............................................................................................h..uQpsspaoQYhh.N.hhlNPA.....h..uG.t.....p..ss..hplthh.aRsQWs.Gl.c..................s..uP...pThshuhstslsp...pp................................GlGlpl..hsD.phGs.....hspsshtssauYp.lpl...........spp...tp................LuhGlpsGhh..phsl...Dhsclsh........................sssDs.hhsss..............sphh.s.husGlhahs........s...............paah..GhSs.plh........s.phs.sstt......................sp.thpahhtuGYhhsls....p...................phph.c...Puhhh+hs.tss.sh..........thDlssp..h..hhpp..............phhhG.....suYR....................hs........sulsshhGhphs...........phtlGYuY-hs..hss..lst......hssGo..HElhlta............................................................................	0	176	283	319
+11584	PF11752	DUF3309		Protein of unknown function (DUF3309)	Mistry J, Coggill P	anon	Pfam-B_1113 (release 23.0)	Family	This family is conserved in bacteria but its function is not known.	20.90	20.90	21.10	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.76	0.72	-4.18	41	288	2009-09-10 20:38:52	2008-11-25 14:50:30	3	1	240	0	131	241	23	49.00	56	91.77	CHANGED	uTILLIlLILlLlGuLP..sWsaSRuWGYuPSGhlGllllllllLlLhGRI	................GTILlIlLILlLlGulP..sWPaSRuWGYuPSGhlGllllIlllLlLhGRI....	0	22	65	91
+11585	PF11753	DUF3310		Protein of unknwon function (DUF3310)	Mistry J, Coggill P	anon	Pfam-B_1078 (release 23.0)	Family	This is a family of conserved bacteriophage proteins of unknown function.	20.10	20.10	20.10	20.40	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.28	0.72	-4.02	30	564	2009-01-15 18:05:59	2008-11-25 15:45:59	3	7	485	0	27	404	1185	61.10	40	51.67	CHANGED	sVsp..PsHYp..psslEsI-hI.t.ht..hpphhuah.hGNslKYlhRhp+K.NG...hEDL+KAtpYlch	..................................lpp..PuHYs........h.......ssl...EhIDhI.p.hs.........h.tthuFs.hGNulKYl...sR..s....st....K..sG...................pEDLpKApaYlp.............	0	6	17	23
+11586	PF11754	Velvet		Velvet factor	Mistry J, Coggill P	anon	Pfam-B_963 (release 23.0)	Family	The velvet factor is conserved in many fungal species and is found to have gained different roles depending on the organism's need, expanding the conserved role in developmental programmes [1]. The velvet factor orthologues can be adapted to the fungal-specific life cycle and may be involved in diverse functions such as sclerotia formation and toxin production, as in A. parasiticus [2], nutrition-dependent sporulation, as in A. fumigatus [3], or the microconidia-to-macroconidia ratio and cell wall formation, as in the heterothallic fungus Fusarium verticilloides [[4].	25.00	25.00	25.80	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.52	0.71	-4.72	28	414	2009-09-11 07:54:36	2008-11-25 15:51:15	3	6	103	0	314	445	0	200.10	30	48.62	CHANGED	shpYcLpVhQQPhRARACGtGs................tDRRPl..DPPPllpLplh-tss....ppt-hshlpssha.hlhssLhssc....shspsph.t.sssss.................................................................................................pshLoGshVuo....hthLc-ssst..................................usaFlFsDLSVRpEGpYRLpFpLhchstts..........................stsssshhs-lhS-sFsVaoAKcFPGht-STsLS+slA-QG..s+l+lR+....-sRt	..................................................................................................................................................t...apL.lhQpP.tARhsG.st..................................t-R+..Pl..sPPPllpL.h...lhc...tp...................tt.s.s....h.ps......a.hhhssL.ssp.......s.tp..sth...............................................................................................................................................................................................................................................................................................................tpsLhGshsuu....hhhL..pc.ssst......................................usaFlFsDLSVRpEGpaRLpFsLhchst.t............................................ttsshhtpshSpsFpVasuKcFP...Ghhp.S...T.Lo+thupQ........G..h+l.lR+.cs.......................................................................................................	0	113	182	260
+11587	PF11755	DUF3311		Protein of unknown function (DUF3311)	Mistry J, Coggill P	anon	Pfam-B_1042 (release 23.0)	Family	This is a family of short bacterial proteins of unknown function.	30.00	30.00	31.30	31.00	28.80	28.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.18	0.72	-4.44	56	487	2009-01-15 18:05:59	2008-12-03 10:22:49	3	2	384	\N	172	357	10	61.80	30	83.95	CHANGED	hhllhlPhlshlhs.PhhNcscPhlhG.hPFhhaathhWlhloullhhlsaph.................................ttttpc	..........h.hLlllPhlsllh.s.shhNclcPhlhG.hPFhhaa.llWlhloullhsllYhh.........................................................tttt.....................	0	36	94	133
+11588	PF11756	YgbA_NO		Nitrous oxide-stimulated promoter	Mistry J, Coggill P	anon	Pfam-B_1030 (release 23.0)	Family	The function of ygaB is not known but it is a promoter that is stimulated by the presence of nitrous oxide [1]. It is regulated by the gene-product of the bacterial nsrR gene.	25.00	25.00	26.90	26.50	21.30	18.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.83	0.71	-4.05	25	846	2009-01-15 18:05:59	2008-12-03 11:49:24	3	3	813	0	106	453	8	107.60	52	93.30	CHANGED	LsG+LtpEacTlpAMlclYC+pH...Ht..............tsthCp-CpsLhcYAcpRLDRCPYGc.sKPTCs+CPlHCYKPp.+cph+pIMRauGPRMLLpHPIhAIRHLlsE++sVPppsstpsS	.................ss.+RIsREKhTIccMIcLYptcp....p................................uuu.spchcuLhsYApKRLD+CsFG..E...-..KPuCKpCP..VHCYpPupREcMKpIMRaAGPRMLa+HPl.LolRHLlD-..+.+sVPchPpc..+....................	0	26	60	83
+11589	PF11757	RSS_P20		Suppressor of RNA silencing P21-like	Mistry J, Coggill P	anon	Pfam-B_1073 (release 23.0)	Family	This is a large family of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of the major mechanisms of defence against viruses, and, in response, some viruses have evolved or acquired functions for suppression of RNA silencing. These counter-defencive viral proteins with RNA silencing suppressor (RSS) activity were originally discovered in the members of plant virus genera Potyvirus and Cucumovirus. Each of the conserved blocks of amino acids found in P21-like proteins corresponds to a computer-predicted alpha-helix, with the most C-terminal element being 42 residues long. This suggests conservation of the predominantly alpha-helical secondary structure in the P21-like proteins.	23.30	23.30	23.50	24.40	21.70	23.20	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.62	0.71	-4.04	3	159	2009-01-15 18:05:59	2008-12-03 13:32:31	3	1	7	0	0	135	0	143.10	82	81.60	CHANGED	+VGAVs+R........TDsLcphIp-FNsSLAllsAMKsDANoD+hsG+aS.AccKL+lLssIEAplRILLcllRR+llRDcLGlRShpDTFcFhlpKYSSL.ocVPaSEVhRpKlKhVuptVIc-LSREHKLDlSERuFPGa...GIL	............................................KVGuVVERLCDPSVTLTEVMDE.INDFNSFLALVHSMKSDMNGDHQDGHHEMGEHKSRLLCNIEAKLRlLLDIIRRRFTR-KLLCTSATDVhGFFVhRYMSS.SHTSFEoVMRTELKLVV.KAVLS-LSRsHKLDFSERAFsAY...GIL....	0	0	0	0
+11590	PF11758	Bacteriocin_IIi		Aureocin-like type II bacteriocin	Coggill P	anon	Lonsdale D	Family	This is a small family of type II bacteriocins usually encoded on a plasmid. Characteristically the members are small, cationic, rich in Lys and Try, and bring about a generalised membrane permeabilisation leading to leakage of ions. The family includes aureocin A, lacticins Q and Z, and BhtB as well as an archaeal member.	25.00	25.00	25.90	52.70	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.57	0.72	-4.35	5	21	2009-01-15 18:05:59	2008-12-04 11:40:09	3	3	20	0	3	13	0	48.30	59	3.59	CHANGED	MA.aL+ll+alAKYGoKAVpWAWcNKGKlL.-WLNlGpAl-WVspKI++IhGl	..AKYA.......IRYGAKYGKKAVKSGWDYGKKVAKSGWNKGKS...IAQKIPRIHKV.	0	0	2	2
+11591	PF11759	KRTAP		Keratin-associated matrix	Coggill P	anon	Lonsdale D	Family	The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.58	0.72	-3.72	22	198	2009-01-15 18:05:59	2008-12-04 14:46:09	3	2	24	0	66	249	1	53.40	52	89.57	CHANGED	Ms..YYusY.aGGhGYGh........GaG.GLGhGY.GCGhu................G.u...........................sGYG.....GsGYG.Ga..GYGs........hpP.sYGtY	.......Ms...YYusY.YGGhGYGh...hG.GLGhGY...G...CGhG........h..G..hG.s......t.GaGY......Gs.GaG..GY..GYGs........hts.hhtth...........	0	17	17	17
+11592	PF11760	CbiG_N		Cobalamin synthesis G N-terminal	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Members of this family are involved in cobalamin synthesis.  The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [1]. Within the cobalamin synthesis pathway CbiG catalyses the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B [2]. The N-terminal of the enzyme is conserved in this family, and the C-terminal and the mid-sections are conserved independently in other families, CbiG_C and CbiG_mid, although the distinct function of each region is unclear.	25.00	25.00	25.40	26.30	24.90	24.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.57	0.72	-4.28	150	1206	2009-09-10 21:45:10	2008-12-09 13:07:16	3	21	1181	2	319	1016	221	83.40	43	18.54	CHANGED	htshlpphap...p.hcsllhlhAsGIsVRtlAPllp...cKpp.DPAVlVlD-sGpalIsLLuGHhGGANpLApplAphLGupsVITTAo-	............h..phlpphap...p.hcslIhlhAsGIsVRsl.....AP......l.lp...sK.ts.DPAVlVlDEpGpaVIsLLuGHhGGANpLu+plAth...L.....Gu.sPVITTAoD.....	0	108	216	280
+11593	PF11761	CbiG_mid		Cobalamin biosynthesis central region	Enright A	anon	Enright A	Domain	Members of this family are involved in cobalamin synthesis. The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [1].	22.70	22.70	22.80	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.90	0.72	-3.75	143	622	2009-01-15 18:05:59	2008-12-10 15:34:47	3	14	614	0	166	505	48	88.40	20	21.68	CHANGED	hhulDhhupt.hGapl...........................sshpshpplsutllsGctl..tlht-........................hh.thphhssp.stp................................................stlhlo....................thttstlhh+P	..........AlDhlApp.hshph.........................................................................................csh.ps.sKplsuhlVstcpVulh.-................................th.ht..h..h..h..p......p.s...phc................................................shlhlo.................h...........h..............................................................................	0	63	122	149
+11594	PF11762	Arabinose_Iso_C		L-arabinose isomerase C-terminal domain	Bateman A	anon	COG2160	Domain	This is a family of L-arabinose isomerases, AraA, EC:5.3.1.4.  These enzymes catalyse the reaction: L-arabinose <=> L-ribulose.  This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into  L-ribulose by the L-arabinose isomerases enzyme [1]. This is a C-terminal non catalytic domain.	25.00	25.00	26.90	31.50	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.35	0.71	-4.52	38	1016	2012-10-02 11:40:13	2008-12-17 11:58:04	3	3	992	9	186	624	33	114.70	58	23.32	CHANGED	sKPplEVHPLuIGGK-DPARLVFsutsGsAlssSllDhGsRFRLllN-V-sVcPppshPpLPVA+sLWcPpPsLcsuupAWIhAGGAHHTsaShulosEplpDaAchsGlEhllI	........-KPhL-Vp.LGIGG.K.-.DP.ARLlFs.sp.s.G.P.AllASLIDL.G.-RaRLLVNslDsVcss+sLPKLPVApALWKspPsL.TAuEAWILAGGAHHTVFSaALshsphcpFAEhtsIElsVI....	0	60	122	157
+11595	PF11763	DIPSY		Cell-wall adhesin ligand-binding C-terminal	Wood V, Coggill P	anon	Pfam-B_85585 (release 23.0)	Family	The DIPSY domain is characterised by the distinctive D*I*PSY motif at the very C-terminus of yeast cell-wall glycoproteins. It appears not to be conserved in any other species, however. In fungi, cell adhesion is required for flocculation, mating and virulence, and is mediated by covalently bound cell wall proteins termed adhesins. Map4, an adhesin required for mating in Schizosaccharomyces pombe, is N-glycosylated and O-glycosylated, and is an endogenous substrate for the mannosyl transferase Oma4p. Map4 has a modular structure with an N-terminal signal peptide, a serine and threonine (S/T)-rich domain that includes nine repeats of 36 amino acids (rich in serine and threonine residues, but lacking glutamines), and a C-terminal DIPSY domain with no glycosyl-phosphatidyl inositol (GPI)-anchor signal. The N-terminal S/T-rich regions, are required for cell wall attachment, but the C-terminal DIPSY domain is required for agglutination and mating in liquid and solid media [3].	25.00	25.00	71.40	71.40	23.40	18.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.72	0.71	-4.33	4	5	2009-01-15 18:05:59	2008-12-18 10:57:59	3	1	2	0	5	5	0	126.40	31	15.91	CHANGED	NDsIsPSYV.Yh-oN...........G.hhASopGss-G..NlFYYDSTlcRllTCss.RPhYplhp-Ds......souFpIhKssDGp..Fphs.usssE.hcl+l.ssGplahTo..hDscsushss.pshRAssVhLpA	NDSISPSYV.Yh-SN...........GauhASosGss-G.lNlFYYDSTlcRIlTCCsVRPlYplhp-Dst.....uoSFsIhKNuDGs..FTasEuusuEPhcL+lLsDGRlahTSs.hDscs.ushs-.cshRAsNVsLpA	0	4	4	5
+11596	PF11764	N-SET		COMPASS (Complex proteins associated with Set1p) component N	Coggill P	anon	Pfam-B_7375 (release 23.0)	Domain	The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans.  The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes [2]. This domain promotes trimethylation in conjunction with an RRM domain [4] and is necessary for binding of the Spp1 component of COMPASS into the complex [3].	25.00	25.00	26.00	25.40	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.14	0.71	-4.35	31	286	2009-01-15 18:05:59	2008-12-18 13:08:07	3	12	199	5	190	257	0	151.20	32	11.68	CHANGED	cpphsthhsL.sl..pshlhDcEDhphL+pshpch..t-hs.......NhphWsW+ppphpt.p...tp.s................spp..cpp......h.sthlpssTGsARoEGa+KIscp-KucYLPH+h+sppshpphphcspt.................................ssttp.suppsSRssRussRRhlusIsspp..h...us-SDlL	......................................................................p.pthh.Lhsh...shshDpEDhpaLphsh....cch.......h.tpc.s...s..h...hNsohWla+pt.hp.th...........................................pp..ppp......hpsthhppsTGsARoEGah+Iscp-Ks+YLspph.hspptt-p.tspspt...................................sspsp.ssppsupppRuppRRLluslssp.......usD..SDLL....................	0	43	78	141
+11597	PF11765	Hyphal_reg_CWP		Hyphally regulated cell wall protein N-terminal	Coggill P	anon	manual	Domain	The proteins in this family are all fungal and largely annotated as being hyphally regulated cell wall proteins, and several are listed as the enzyme EC:3.2.1.18. This enzyme is acetylneuraminyl hydrolase or exo-alpha-sialidase, that hydrolyses glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.	25.00	25.00	28.60	35.30	22.80	24.60	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.93	0.70	-5.68	8	149	2009-01-15 18:05:59	2008-12-19 16:57:30	3	11	20	0	117	153	0	315.40	33	36.77	CHANGED	llslhhllssshAlsITps+VDRGslsLslGDITIpuGuaWSIIDNulosFsGsLpVpsuAGLYIoSTSsLLALQVTLsShLuSIpNsGlIoFNShsSLTuosYsLlGlSFsNsGEMYLuASG.shssshulTuuoWoNsGLLsFYQNpRooGsVSLGsPhGoIsNNGQICLaNclYpQTTpIsGoGChTANpsSoIalSNsLLslsosQsFYLADSpSSlhspAlSsspTFNVYGFGNGNpIGLsLPLlu.s.hssAYsYDsoTGILTLR.sGhLuQcFNIGhGYssuhFpIVTDsusGLsSs.hGuloYSGPVPsRsLPusCQ.PCKPlPsuP	..........................................................................h..hhhhht..hh.u...h.pls.p.spl..shGsh..shsh..G.Dl.pIpsG.uhaSIl.sN...s...h....ssahGsl..pVppsuuhYIooss.s..h.l.uLpVs...l.h......s.hhts..lpNsGllsh.suh.p.ohs.ussasl.hGh..o.FpN..sG..-hah..uu..sG....hs..ss.s.hs...l...s.u.s.s.W...pNs..GLlsa.aQ..s.p.+..o.s.....Gs.....l.p.L..G.t........s.......h....s.....oI...sNsGpICLpNps.apQ.s.o.sIpG.oGClo..sspsSsl..a..l....sN..s.hh...s..lsssQshYLssspS..Sl.h............s..p.uh..u.s....sp.Ta..pVhGFG.....N.....G..N+..I...GL.......shsL..h...s......h.................ssasYsssoGILTL.......p......s..sh.........h..s.pp...FsI....GhGY-sshF.p.l.s.o.D.s.ut.Gl.sshhGu..lpYsGssPs.t..sh.Ps..Cp.sCpshPthP........................................	0	12	44	117
+11598	PF11766	Candida_ALS_N		Cell-wall agglutinin N-terminal ligand-sugar binding 	Coggill P	anon	Candida_ALS	Domain	This is likely to be the sugar or ligand binding domain of the yeast alpha-agglutinins.	25.00	25.00	28.10	27.70	20.00	18.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.73	0.70	-5.47	24	165	2009-01-15 18:05:59	2008-12-22 09:42:18	3	36	42	5	84	174	0	240.80	38	24.30	CHANGED	sWsl.DGsssssGDTFTLpMPsVFKFpss..psolpLss....ssssYAoCsh.sG-hhssaSpLpCosssslss..spps.GolshPlsFNsGGSusssDLpsuppFsuGsNTVoFsDGspplSsoVsF-uus.......ssssshlhtuRhsPolsphphahluspCsNGYsSGs...lGaossss..tlDCSslpstIosplNDWhaPpoucs.hsaohoCousu..lhIoapN.lPAGYRPFl-uhh...sssssshphsasscYpC	......uWsl.DGossssGDTFTLsMPCVFKFpos.....psolsLss......sussYATCshpsG-.hssaSoLpCTlss....slss..stpAhGolohPlsFNlGGSusssDLps.SpsFsuGsNTVoFsDGs...pplSssVsFpsss..........ssssshl.h..tuRhhPolsc.hps.hhluspCsNGYpSGs......lGas..ss..ss....sssID.CSslclu..Io..NslNDW.aPh.oucs....hoaohoCousu..lhIoapN.lPAGYRPFlDAhl....sss..ss..shshsYpNpYsC...........	0	10	23	82
+11599	PF11767	SET_assoc		Histone lysine methyltransferase SET associated	Coggill P	anon	Pfam-B_8752 (release 23.0)	Domain	SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. A subset of SET domains have been called PR domains. The SET domain consists of two regions known as N-SET and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance.  Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure [2]. This domain is found in fungi associated with SET and N-SET domains.	21.00	21.00	21.10	45.10	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.16	0.72	-4.66	20	114	2009-01-15 18:05:59	2008-12-22 13:49:53	3	4	113	0	88	118	0	69.40	38	5.99	CHANGED	aIsccaVPspssosp-lK+pL+pYsWsclhs-+oGaYIlFsshc....EAc+CapspsspthFsac.....hhMc	..FIu+paVPlhssolsHlK+RLKtasacclR.sD+TGaYIlFpsoc.G...p.EsERCacssstpthFsYp.....MsMc...........	1	15	43	75
+11600	PF11768	DUF3312		Protein of unknown function (DUF3312)	Mistry J	anon	Pfam-B_5984 (release 23.0)	Family	This is a eukaryotic family of uncharacterised proteins. This family shows similarity to WD40 repeat proteins.	26.20	26.20	26.20	26.20	26.10	25.20	hmmbuild  -o /dev/null HMM SEED	545	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.64	0.70	-6.28	7	103	2012-10-05 17:30:43	2008-12-22 14:09:06	3	6	72	0	71	106	0	404.70	39	68.62	CHANGED	KppasEuRGh.Wol+N...K+Pp+LRDsLKcLEEhLppppslhs+W+sphhhQLhhusGlLlp..ls..sspLp+VhhD+.LVGKLhu-pIoDAllTcoaIllSa.spNplshVpLpK.sshs....ppLEKlShhD.KIpas.I...PGsssR+lsR+LslNupQ-lslsWhtssps-V.aPWpPssp-pDRANlhlhphsus.pLElLsYhhTEhDPlsVpFSh.psaQlhTVEpplutps-...shhDsCIYEhs+sKhcRVuVTpIPLpoplsssAhsssc-KLhLGC.DuSllLaDttRtlThLs.pAslhPshluWHssuullhVusppGpLQsFDlALuslphQLluE..-stPpusLpLppaF....sss.sLsclpWu.tP.lspptcshspssshLhLhF-pGPLuslphhhGshh+GpltsstLhu.....pYI+hsQV-cAlslLtShNWsThGt.ChhuhptIsNalh+t.Lss-REsQLEtsLGoFhsPs+PLs-pThLEapD.VschsRRFFHaLLRhppFpKAF.LAlDIsstDLFMDlH.lAtshG-lsLAc.A	.........................................................................................K.ph.pt...Rsh.hh.cN...+pst+L+csL+.lE-hhpppphlhspWpst....h..lhhssGllhp..ls..sspl.phhh-+.LhGKL..p.lsDshhoppallhsa.tpsplshl.hp+..t........pt.-Klu.h-.+l.hh.l...sG.s..s+phtR+LslNt.tDhh..lsWh..sp..s-s.aPWtP.h.p-p-RANlhlhthtth.pLElLs.hhTEhsP..lsspFs.hpps.plhTlEppluhct-..........s.s-.ChYEh...........s......p.s...K.hp.p.h.......ulTpl....Pltopshssshsssc-+LlLGC..D.uolhLa-............hpp..sTh...hs.ps.......t.ll.........PshluhHssuullhVusppGpLQhFDhALuslphQLluE...sh.Ppph...Lphs..phF......thp.sLhphpW..ts.h...t.t.sph..shL..hLhacpGP..luslhhhh.GhhhpG..plt..tlh.......pYl+hsph.cAlslLtuhNWsT....h.Gt.ChhshptIs.NaLh+t.LsspREsplEtsLGsFasPs+PL.-ssh.EapD..lpchsRRFFHaLLRhphatcAF.lA.DltshDlFhp.......................................................................	0	29	34	52
+11601	PF11769	DUF3313		Protein of unknown function (DUF3313)	Mistry J	anon	Pfam-B_1303 (release 23.0)	Family	This a bacterial family of proteins which are annotated as putative lipoproteins.	20.70	20.70	21.50	20.70	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.00	0.71	-4.95	64	738	2012-10-02 17:45:13	2008-12-24 10:50:44	3	4	658	0	152	414	39	195.50	44	87.44	CHANGED	lhluGCuus.sp.......uuhlss...astLppsp...sstsshpahssshc........hspYsplhl-Plph...............h.t.spsshp.lsp.psh....pplssahsptlppplupp..hpls..spP.uPsslhl+sAlTslssss.slpsh.cllPhuhlhsssptu....sGtpstssplshEsclhDusoscllutsVc+ttupsh...stsspsh.shsss+ssl-paApchsp	...........................LALoGCASKlspP-p..............YSGFLss...YScLpEoTS.AoG+PlLRWVDPsac........tSp.YD.s.IlasPlTY......................YPs.PKPoo.Q.V.uQ...psL....-clLsYsNschKcAIupR....pPLV.....TTs..GP+oL..IhRuAITGVDTSK......E....G....LQFY....EVlP....VA.LlVAGTQhA.............TG+RTMDTcLaaE..uELIDAATNKPVlKVVRpGp.GpcL.................sNpoTPh.u.h-slKpVlD-hAsDs..p..............................................................	1	30	68	109
+11602	PF11770	GAPT		GRB2-binding adapter (GAPT)	Mistry J	anon	Manual	Family	This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells [1].  In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation.  It associates with GRB2 constitutively through its proline-rich region [1].	20.80	20.80	22.60	21.10	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.96	0.71	-4.55	3	26	2009-01-15 18:05:59	2009-01-05 11:29:25	3	2	23	0	15	20	0	149.50	60	96.31	CHANGED	MLKsCGNosVAVSVGISLLLLLVlCGIGCVWHWKHRsoTRFTLPKFLQRRSSR+KDsTKTFSLSPplIGPRHKsSVETQDHKSAuKcNNhHDNYENVEVCPPKAKGcTDKcLYENTtQSNhEEHIYGNETssDYYNFQKPSPSEsPQDEDIYILPDSY	.....MLKSCGNs.sAISVGISLLL.LLVlCGIGCVWHWKH...+suT.RFTLP+FLQRRSSR.+K.ssTKTh.LuPclIG.+HKhSVcTpDH+Sus+ssslHcNYENVEsGPP+sKtcTDKELYENTpQoNFEEHIYGNETuS-YYNFQKPpsScsPQDEDIYILPDS...	0	1	1	3
+11603	PF11771	DUF3314		Protein of unknown function (DUF3314) 	Coggill P	anon	SwissProt (UPF0575)	Family	This small family contains human, mouse and fish members but the function is not known.	25.00	25.00	150.50	42.80	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.41	0.71	-4.48	3	44	2009-01-15 18:05:59	2009-01-05 12:59:39	3	2	29	0	22	33	0	150.10	65	57.07	CHANGED	MFASFuFssLEE.sPLSVSHFuIGQssIc.uh+VSIFRYCsPTPYLASuhTG.LYK+MRWNVEtssEusGcGcsaDu..........SlsEYYFLCYEDThEsAc........EutsossDSsuclsRlWSIGRWVpotPpssTDDllDWlLCPlPsGsYKQLLsLG.EEPSSshATDLLVQlL	...MYASFGFVsLEETsPL....SISCFFCGRFSIS.SH.-VSIFRYCsPsAYTAS+FPRYLYKKMRWNLEsTs.E.ssupGp-.............ShVDYYFLCYRDTWE............DsGpoPAN..SCPQIQKLWSIGRWVPLGP...s.-DDLhSWILCPQPsGDYQQLLTIGFEEPSphLATDLLVQlL.............	0	1	3	7
+11604	PF11772	EpuA		DNA-directed RNA polymerase subunit beta	Mistry J, Coggill P	anon	Pfam-B_4675 (release 23.0)	Family	This short 60-residue long bacterial family is the beta subunit of the DNA-directed RNA polymerase, likely to be EC:2.7.7.6. It is membrane-bound and is referred to by the name EpuA.	21.30	21.30	21.60	23.40	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.24	0.72	-4.52	20	529	2009-01-15 18:05:59	2009-01-07 11:27:24	3	1	523	0	56	207	0	47.00	48	72.40	CHANGED	lll.VllLhllsLslGLMlGYullGsG.sPhslLp.cpWpcIlshhptp	........lll.VllL.uhLsLslGLMlGYGllGcG.sPauILSPspWpcllpKFTGp...	0	14	30	42
+11605	PF11773	PulG		Type II secretory pathway pseudopilin 	Mistry J, Coggill P	anon	Pfam-B_4690 (release 23.0)	Family	The secreton (type II secretion) and type IV pilus biogenesis branches of the general secretory pathway in Gram-negative bacteria share many features that suggest a common evolutionary origin. Five components of the secreton, the pseudopilins, are similar to subunits of type IV pili. Pseudopilin PulG is one of the secreton pseudopilins, and is found to assemble into pilus-like bundles [1]. PulG interacts with proteins H, I and J within the multi-protein complex as well as blocking extracellular secretion and reducing the amount of PulE protein as well as the amounts of PulL, PulM, PulC and PulD when G is over-expressed [2]. In Klebsiella the pilus-like structure is composed largely of PulG [3].	25.00	25.00	28.90	28.90	22.30	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.44	0.72	-4.25	9	340	2009-01-15 18:05:59	2009-01-07 11:56:40	3	1	333	0	23	146	0	79.20	58	88.03	CHANGED	ILLESLlAlAlLssIsoLlLoplspsRpctspphpppElLslApMAlQTpQccLolNGlsIplpcopptlhlacpucEllcl	.ILLEAlVALAIFASIATLLLGQIQ+NRQEEAclLQKEEVLRVA+MALQTGQsQloINGVEIQVhuSEKGLEVYHGoEpLLuI....	0	1	5	13
+11606	PF11774	Lsr2		Lsr2 	Mistry J	anon	PD026347	Family	Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes.  It is a functional homologue of the H-NS-like proteins [1].  H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression [1][2].	21.00	21.00	21.30	21.00	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.38	0.72	-4.14	69	720	2009-01-15 18:05:59	2009-01-07 13:29:32	3	16	402	5	243	584	10	101.80	37	66.89	CHANGED	MAcKVhVp..LVDDlDG.utA-...ETVpFuLDGVsYEIDLSscNAs+LRpsLp.alssuRRlG...ut....c+ut....................sssps.pssts+cpsssIRcWARpNGapVSsRGRIPu-ll-AYctA	.............................................................................................MAp+hhl..pLlDDlDG..s.A-....-oVpFuL..D..GhsYpIDLospNA.pcLRp...s...Lt.a..lttuR+su.tp.......................................ttsts...pssssptpsstlRpW....A+p.sGap......V.....SsRG..RIss-lh-AYctA........................................................................................................................	0	94	195	223
+11607	PF11775	CobT_C		Cobalamin biosynthesis protein CobT VWA domain	Bateman A	anon	Pfam-B_10956 (release 9.0)	Domain	This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid [1]. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.29	0.70	-4.92	2	462	2012-10-10 16:07:06	2009-01-07 13:44:22	3	6	430	0	134	465	1894	195.60	50	32.61	CHANGED	sFh+cc-tphhsssVp.llD.SGSMtGR.IplAhssA.hlAcsL-RhsV.s.IhGFTTh...Gu.shEsh.ttGhst..uhh.slh+.h.cpAsuP.hRAR..hGhhhcph.LhpNlDGEuls.htphhhGR.Ep+KIhhhhSDGAPs.......sAGshhcpHLRplhcEIEThS.l-LhAIGlhpDssR.YY+phshlsssEELGsulspcLuclh.t	...........................................saKpE+-.scF+DTVVTLLlDNSGSM.R......G......RPI....slA.AhsADlLARTLERC.G.VKlEILGFTT......+....A......W.K.G...G.p.u.REtWltt....G..+..P......t.t..PGRLNDLRHIlYK..s..ADsPWRRA....RpsLGLMh+.EGLLK.ENIDGEAL..WAapRL.huRsEpR+.ILMlISDGAPVDDSTLSsNsus..YLEc.HLRtV.I....ptIEs.....+u.sVE..L.lA..IG.I..G..H....D...V...TR...YY..p..+.AVTIscs-pLuushhppLutLF..p........................................................................	0	34	83	104
+11608	PF11776	DUF3315		Domain of unknown function (DUF3315)	Mistry J	anon	PD456999	Family	This is a Proteobacterial family of uncharacterised proteins. Some of the proteins in this family are annotated as being putative membrane proteins.	23.30	23.30	23.40	23.60	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.49	0.72	-4.44	112	1010	2009-01-15 18:05:59	2009-01-07 13:51:14	3	4	799	1	169	569	18	51.00	42	38.50	CHANGED	Gc+lP.spYRsc.pYslcDW+tapLssPs+Gh+Wlths.GcYlLlshuoGlIlpl	................G-plP.phYRsc.cYsIcpWp.h+.s.LPAPstG..p+WshhG..GsYVLIssssGpIlc.........	0	21	61	115
+11609	PF11777	DUF3316		Protein of unknown function (DUF3316)	Mistry J, Coggill P	anon	Pfam-B_4718 (release 23.0)	Family	This family of bacterial proteins has no known function. Several members are, however, annotated as being putative acyl-CoA synthetase, but this could not be confirmed.	24.40	24.40	24.40	24.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.35	0.71	-4.31	23	216	2009-01-15 18:05:59	2009-01-07 14:36:55	3	1	189	0	28	150	0	126.10	28	67.67	CHANGED	MKplhlls.....hhlhhussuhA...............shtpp.pspolpssshso+psAYsh........Ghshlpshptpos....ppLstcLplhsp..hshpsh+lpD.upVoVpchhpss...............GplpYpshlclcac.....................YphRsuN	..............................................................Kphllhh.....hhlhhu.ssuhA...............th..t.pscol.p.us.hhsoppphY.us........Ghspl.ph.h.Pp....phhup-Lpl..hpp...hs.+s.s+lps..spVs.VQphhpts...................GhlpYpshl+hsap................................YphRpoN.............................................................	0	4	14	24
+11610	PF11778	SID		Septation initiation	Wood V, Coggill P	anon	Pfam-B_41015 (release 23.0)	Family	This family is required for activation of the spg1 GTPase signalling cascade which leads to the initiation of septation and the subsequent termination of mitosis. It may act as a scaffold at the spindle pole body to which other components of the spg1 signalling cascade attach in pombe [1,2,3]. In S.cerevisiae it is both required for the proper formation of the spindle pole body outer plaque and may also connect the outer plaque to the central plaque embedded in the nuclear envelope [4].	25.00	25.00	27.80	25.80	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.72	0.71	-4.27	9	50	2009-01-15 18:05:59	2009-01-08 14:46:36	3	1	38	1	31	52	0	130.50	28	20.46	CHANGED	slpplpGNssphlT.-sltpph.phs+Ep..YssLtl-plDplshVphQNhlKslllhLcIPasKLpp+lPLluIpLpaEpphLhpFANpLHhhlYsc.lshKphTp.Ahs-alps+shtplcHPLc.CL-sLacpltpp	........................htpl.Gssuptlshcsltpsh..clspcp...YspLtl-plDslshlpLQNllKslllhltIPatplhcplPhlsIpLphEhtlltpFsscLHhplYs..pphshK...p...hss...Ahppahps.pp.hsplcH.Lc.CLptLacplh..t...................................	0	6	18	30
+11611	PF11779	DUF3317		Protein of unknown function (DUF3317)	Wood V, Coggill P	anon	Pfam-B_3618 (release 23.0)	Family	This is a short family of proteins conserved from fungi and plants to human. One each of the human and mouse members is annotated as being androgen down-regulated protein expressed in mouse prostate, with a potential signal transduction function, and all appear to be membrane proteins.	25.00	25.00	25.00	25.50	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.71	0.72	-4.53	27	282	2009-01-15 18:05:59	2009-01-08 14:49:58	3	3	177	0	194	250	0	56.70	29	53.89	CHANGED	thtcalphhhapYplThulYhls.PhE+hlhNshl....hhllthllhuhhha....lPspltthhp	........h..hpalphhhYpYplshulYML-.PWE+hlF......Noll....lslluhlla.ssala....hPpalhhhh.t................	0	44	78	133
+11612	PF11780	DUF3318		Protein of unknown function (DUF3318)	Mistry J	anon	Pfam-B_1341 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.30	22.30	24.30	23.80	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.67	0.71	-4.63	18	198	2009-01-15 18:05:59	2009-01-08 14:52:58	3	1	158	0	68	175	98	138.50	29	75.94	CHANGED	hp+LpshhPsuhRhplhls.Apscptpllpuhh.h....sptphhlshshWhshshspRslhhh+psuhhps.......ppa.tlshh.ulslsGhhssslphsptcsltlslAuGLuuhushplWppspu...spsplsADp.tAlchAscpGY	.......h.pcLpshhPhtlRp.lhlhtusspp.pLhpstt.hR.....splphhhsLpha.shs.hspRsLhhh+p.suplps..................spaPh.uh.h.uhlhhGhstulhchhspcuLthshAlGLuuhtuYRlWppspu....ctshtADt.tA.t.u.c.........................	1	11	37	56
+11613	PF11781	RRN7		RNA polymerase I-specific transcription initiation factor Rrn7	Pollington J	anon	Pfam-B_4705 (release 23.0)	Domain	Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [1,2]. 	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-8.02	0.72	-4.45	25	186	2012-10-03 10:42:43	2009-01-08 17:32:32	3	6	161	0	119	197	6	34.60	32	6.39	CHANGED	hphh.cs.t..Cuh..Cput....hhhsc-GhaaC.pCGsht-	..........h.ct....Csp..Csup....hhhtc-GthaC.psGphhE...	0	24	50	90
+11614	PF11782	DUF3319		Protein of unknown function (DUF3319)	Coggill P	anon	Pfam-B_4745 (release 23.0)	Family	This is a family of short bacterial proteins, a few of which are annotated as being minor tail protein. Otherwise the function is unknown.	25.00	25.00	28.40	46.60	19.40	22.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.06	0.72	-4.18	9	129	2009-01-15 18:05:59	2009-01-09 10:19:37	3	1	128	0	20	64	2	77.90	55	71.29	CHANGED	MtpslY.RGa.LpsusussshW+spIKs+llpGsLsAVKKSIDWWhDTuolIDP+EFsulsppp...tsouspoEsapGapIKNDTGEPNtW	.Mth.hY.pGF.Lpsstspsp.WplpI+sp.hsGsLuAVKKSIDWFCDTASIIDPKEFpSlGpK+...psuuuspEpFNGaTIKNDTGEsNcW.....................	0	2	5	14
+11615	PF11783	Cytochrome_cB		Cytochrome c bacterial	Mistry J, Coggill P	anon	Pfam-B_4681 (release 23.0)	Family	This is a family of long bacterial cytochrome c proteins, found in Proteobacteria and Chlorobi families.	21.00	21.00	21.10	22.90	19.30	20.80	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.46	0.71	-4.70	41	134	2009-01-15 18:05:59	2009-01-09 14:18:37	3	13	96	1	78	132	23	171.90	31	31.52	CHANGED	KhhWDWSpAGp..........................p.....t.sp.sahppKGsF....patc.sltPpYtWaNG.phphhhhs-tlc.s.............sps...ltlstPhGshsDst.u+IaPFKlapG+QPYDtptppllsscha..G.................tuhWss.....aDaspAlptGhc.............................................ts......Glta.....SGca.....................................sFlcTphaaslsHhVuPK-cA.L..pCs-CHspsuc	.........................................ch.WDWupAGp.t................t....................tt.sp.sY.thKGsFtatc.slhPtYtWaNG.phph.hhhs-ths..s...............sts....splstPhGshsDsp.u+IaPFKlapGcQsaDttpppllss..cha.................t...suaWps.....aDaspAlptGhc...................................................ts......Gl.a.....SGca.................................................................................................sFlcTphaaslsHhVuPKc.cA.L..sCs-CHssss....	0	23	48	71
+11616	PF11784	DUF3320		Protein of unknown function (DUF3320)	Coggill P	anon	Pfam-B_4770 (release 23.0)	Family	This family is conserved in Proteobacteria and Chlorobi families. Many members are annotated as being putative DNA helicase-related proteins.	25.00	25.00	25.20	26.00	22.10	24.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.52	0.72	-4.44	41	216	2009-01-15 18:05:59	2009-01-09 14:23:31	3	10	211	0	81	219	9	51.20	28	3.04	CHANGED	ssthhpts.pshLtphlpcllphEGPlpcshLscRltpuaGhpRsG....sRIppt	.........t.hptp.tshLtphlppllcsEuPIppshLspRltpuaG.lpRsG....s+lcp...........	0	28	46	61
+11617	PF11785	Aft1_OSA		Aft1 osmotic stress response (OSM) domain	Mistry J, Finn RD, Wood V, Wahls W	anon	Manual	Domain	This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The OSM domain has been shown to be involved in the osmotic stress response [1].	21.60	21.60	22.00	22.00	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.01	0.72	-3.43	10	122	2009-01-15 18:05:59	2009-01-14 09:32:12	3	6	114	0	86	120	0	51.10	40	9.37	CHANGED	sosu-.sspuLAPPsRsusptp.......ssTPDYFuulps..shuLEPNPFEQSF......Guuss-......TP	...................................s.............s.p.s.............ssss.shhst.ts.....shsLEPNPFEQSF.........Guss.-...s................................	0	23	45	72
+11618	PF11786	Aft1_HRA		Aft1 HRA domain	Mistry J, Wood V, FinnRD, Wahls W	anon	Manual	Domain	This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The HRA domain is involved in meiotic recombination.  It has been shown to be necessary and sufficient to activate recombination [1].	25.00	25.00	25.00	26.50	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.77	0.72	-3.72	5	90	2009-01-15 18:05:59	2009-01-14 09:44:44	3	6	87	0	65	91	0	79.20	61	14.87	CHANGED	PuuusP..asW.usuSLRoG....PLSPAMLsGPTG......SsDYFSssu+hpu........GFPTPNESSLRTGLTPG.GuG.............SMFPAPSPNTQAlLsp	............sso..suss..asW.........ssSLRoG....PLSPAMLuGPst......ssDYFssht+..............GFPTPNESSLRTG....LTPG...GuG........................SMFPA.P.SPNoQAlht.................................................	0	16	33	52
+11619	PF11787	Aft1_HRR		Aft1 HRR domain	Mistry J, Wood V, Finn RD, Wahls W	anon	Manual	Domain	This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The HRR domain is involved in meiotic recombination.  It has been shown to be necessary and sufficient to repress recombination [1].	25.00	25.00	34.60	33.50	19.20	22.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.47	0.72	-2.93	9	76	2009-01-15 18:05:59	2009-01-14 09:46:02	3	4	72	0	57	73	0	75.40	49	14.56	CHANGED	uATPuTI-FHRTAlsAA...................cpss..usTSpP.pstsptsp....sshshpPsps....PFs.HDssDAANGLaMLApGs	....GATPoTlDFHRTAlsAA.........................pp.....s.....t.............u...sT...SpP.p-.sst.hpt......sph-hcssss.....PFs.HDssDAANGLFMLApGt.	0	9	26	45
+11620	PF11788	MRP-L46		39S mitochondrial ribosomal protein L46 	Wood V, Finn RD, Coggill P	anon	Pfam-B_1897 (release 23.0)	Family	This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.	21.90	21.90	22.70	22.10	20.90	21.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.41	0.72	-3.40	37	276	2009-01-15 18:05:59	2009-01-15 13:02:55	3	6	247	0	192	272	0	110.20	24	36.02	CHANGED	hplpuullLpR.PllotchsshEppa..a.........pcL.c+l.hpasphhhachsohs-h.ca.t.ptp.hppp.t..h..sh.ph.tpphpcp.cpplt.........................................pPssRlT..-AD	..........................clhuullLpR.PllopplsshEppa............pcL.c.plphphsth..achts.t-......ch.....ptph.h.pp...p..............s.tth.h..hp.......pht.p.c.thtt..............................................................pPtsRhTcAD.......................................................	0	54	98	153
+11621	PF11789	zf-Nse		Zinc-finger of the MIZ type in Nse subunit	Wood V, Coggill P, Finn RD	anon	Pfam-B_1696 (release 23.0)	Domain	Nse1 and Nse2 are novel non-SMC subunits of the fission yeast Smc5-6 DNA repair complex. This family is the zinc-finger domain similar to the MIZ type of zinc-finger [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.23	0.72	-4.45	22	399	2012-10-03 15:03:13	2009-01-15 16:14:09	3	17	271	2	265	1659	117	59.30	29	18.81	CHANGED	D-ltlpp..sphsLpCPlThpshcpPVps+.........pC.sHsFE+puIhphl.....................pptppscCPl.uCu	........................................-l.hpt....t....hshpCP.lT...tt.......h...c...p...P..Vpsp........................pC...sH..s..a.-+.c.uI..hphl.............................................p.p..p..pp.h..pCPhhGC............................................	0	102	155	226
+11622	PF11790	Glyco_hydro_cc		Glycosyl hydrolase catalytic core	Wood V, Coggill P, Finn RD	anon	Pfam-B_1680 (release 23.0), IPR013781	Family	This family is probably a glycosyl hydrolase, and is conserved in fungi and some Proteobacteria. The pombe member is annotated as being from IPR013781.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.93	0.70	-4.94	51	454	2012-10-03 05:44:19	2009-01-15 17:13:44	3	34	246	0	280	584	106	211.60	20	50.29	CHANGED	Gluas......sss.........spth....ttsusloWh.YNWs.hssushsst.........EFVPMlWGsp.st.......shhsslpss..............tsspalLuFNEPDh..ss...QushsP.psAAphahphhpP........tss+lsuPul..ssu..........sh......WhppFhss...Cs..................sC......plDalulHaY.......ss.sss.hpsalsphhstas........cPlWlTEFu..t..........sssssppp....pppFhppslsal-sp...shVpRYuaFs.............s..ssssstLlstp......G.sLTslGphY	....................................................................................................................................................................thsWh..Ysat.......................palPh..has.t..........t.htt.h.th.....................t.phlh..sa...NEPDh....ss..........tush.ss..ttAstha...phh.t.s.................thpls....uPuh..sss.........shs.........W.l.p..p.Fhps...sp.....................ss......phDalslHaY..............................tss..hps...h..hs...hl...pph....h...s...t.as......................cPlWlTEau.......................................stsstpp.............ttpa.hppshs..hh.-t..t............shV.t+Y.uaFt..........................hhp...t...........u...tho.hG..a..................................................................................	1	99	179	242
+11624	PF11791	Aconitase_B_N		Aconitate B N-terminal domain	Bateman A	anon	Pfam-B_2605 (release 10.0)	Domain	This family represents the N-terminal domain of Aconitase B.	21.70	21.70	21.70	25.90	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.91	0.71	-4.40	94	1508	2009-05-07 16:09:31	2009-05-07 17:09:31	3	5	1476	2	324	1082	761	149.10	63	17.65	CHANGED	sY+pHltER.us..GlPPhPLs.A-QTupLlELLKsPPsu.-cc..................................aLL-LLppRVPPGVD-AAaVKAuFLsuIspG-sssslIottcAlcLLGTMhGGYNlpsLl-hL....cDsc.................lAstAAcsLppTLLlaDA.FcDVt-hucs.NsaAKpVlcSWAcAEWF	.....tYR+HVtER....A.A...GIsPhPLs.ApQsAsLVELLKN.PPsG...EE-..................................FLLDLLpNRVPPGVDEAAYVKAuFLAAlAKG....-spSPLlo.........sc+AlELLGTM.GGYNIcPLI-hL....DDsc..................LAslAAcALp+TLLMFDs.FaDVpEKAKAGNta....AKpVlQSWADAEWF.....	0	75	179	264
+11625	PF11792	Baculo_LEF5_C		Baculoviridae late expression factor 5 C-terminal domain	Bateman A	anon	Pfam-B_5141 (release 7.6)	Domain	This C-terminal domain is likely to be a zinc-binding domain.	20.30	20.30	20.30	20.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.38	0.72	-4.57	24	63	2012-10-03 10:42:43	2009-05-07 17:12:19	3	2	61	0	0	99	2	42.90	50	16.91	CHANGED	pLpslNGholct.C.pHcal..shE+QhRAGDEhVSFI+YCphCshh	................L.slsGhoL+t.C.pHcFl..T.lE.+QhRAGDEhVSFI+YCphCsh.h.	0	0	0	0
+11626	PF11793	FANCL_C		FANCL C-terminal domain	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3268)	Domain	This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.86	0.72	-4.01	10	241	2012-10-03 15:03:13	2009-05-07 17:18:36	3	10	152	2	176	501	25	65.60	32	9.50	CHANGED	tph-CGICaAYRL.........sGplP-hsCDNP+Cup.FHpsCLhEWL+oLhsSRQSFslhFGpCPYCsc.lolcho	....................-CsIC....a.uh.h.h..............................ss..sl..P.c...hs..C...cs.pCsphFHpsCLhc...Wh...pu.....t....s...o...p...p..........h.........h..G...p...CPhCpp.lt....h....................	0	50	77	128
+11627	PF11794	HpaB_N		4-hydroxyphenylacetate 3-hydroxylase N terminal	Bateman A	anon	Pfam-B_3148 (release 6.5)	Family	HpaB Swiss:Q57160 encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli [2]. HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This family also includes PvcC Swiss:O30372 may play a role in one of the proposed hydroxylation steps of pyoverdine chromophore biosynthesis [1]. 	30.00	30.00	30.50	43.10	29.10	29.60	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.52	0.70	-5.00	80	1009	2009-05-07 16:38:44	2009-05-07 17:38:44	3	4	755	14	223	742	285	248.40	39	52.63	CHANGED	TGc-Yl-SL+.ct+..pVYltGE+V.t.-VssHPsh+sslpuhAphYDht...a...........cschp-......hhThhospsup.tssphaplscot-DLht+pchhcthuchotG.hh..sR..usDhhsuhhsshtst..chaus.............atcshpcahchsp-pDLhhstAhssPpsDRu...pss......pps.Dlhl+VVccs-c..........GIlVcGAKhhsTuushocplhlhshts......h.stt-...c-aAlsFulPhssPGl+hlsRpuhpsstt....ssaD.Pluu+a-..EtDulllFDcVhVPWE+VFh	.................TGp-YlcSLp..-s+..clYlhGE+Vc..DVosH........P......uFRsuhtolAplYDhh.a..........csph..p-..........hhshs..ospsut.hsp+.a.FchscSs-DLhppRcuhtpWu+ho.h.G.hhGR....oPDahsuhhsshtsss.thaGp.............atpNhcsaYpchp-ssLhhsHAllsP.hDRp...css.........pcstDlal+l.cEs-s..........GIlVSGAKslATsusloc..hlh.sss.........hhscs....tDaAlhFssPhDu.GlKlIsRtuap.sssh...tosaDaPLSSRF-..EpDAllVhDcVhIPWEpVhl....................	0	83	142	186
+11628	PF11795	DUF3322		Uncharacterized protein conserved in bacteria N-term (DUF3322)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4924)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the N-terminus.	21.60	21.60	21.60	22.00	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.05	0.71	-4.65	30	182	2009-09-11 10:44:22	2009-05-07 17:43:26	3	3	174	0	63	162	20	178.50	24	46.76	CHANGED	PsDl+tpl.pRhWccuplhtuhhts..pshaPhpLsL+sPsupplupchs.pVRcWl.pplpss........ups.......clcW+plsaRh.hGpsplPsclhlcohpcAlsllG+p.....pphpp.acthlphspsphPpLlshltpcPhpsl..chustW........spllsllcWhppHscsGlYLRplslsGV.coKFlE.p++ulLscLLDl	.................................................plttpl.t+.apptphhtthhhs.......tsh.aPh.p..lslthP.sstthstphp..sl+pal.pshpph...........utt......plcWcphph+h..hu.ssplPsclhlss...s....phlshhGcp......tchpp..hp....phhtt.httphs.t...Lht.h..h.........thh....phtpth................thtpllsllpalpt.p..ss.sGh.h...lRplslsGl.DoKalE.p+pullspLls..................	0	22	46	60
+11629	PF11796	DUF3323		Protein of unknown function N-terminus (DUF3323)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Beta-proteobacteria).	25.00	25.00	28.50	27.90	23.70	19.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.32	0.70	-5.02	17	132	2009-05-07 16:45:11	2009-05-07 17:45:11	3	5	126	0	50	132	0	205.00	23	50.04	CHANGED	sphsGslpLss.ot.--+puLusLhGRsht..stshplslsch-ss.Lpss...thsshsLtcsL-thhGshlpppppctttppphtphaht.....t.p.hht......psttttWhpplhsttt.........lpphhtss.ctstpllppsspsLttL........s......th..lulhAuplsG..DsHuhDsspssupLlLpAL..............httsptsssss-t..................+pplatpsGllhD-lSsssLshulhshs	...................................................................................................................hsGtlpLp.shst.pE+psluthhG..+sht..tpphplslsph-ps.Lppo....thtshsltplLpthhG...l..p.p.pccpttp.ttppptaht............th.th.ht......pshh..tp.Wlppl.hptth..........ltphh...tps..pt.hp..phlthshpslsp.L...........................Ph.t......p...LslhAspls.u..DsHuhDpsp..supLllpuL..................thhhst.p..s.psucp..........................ppcLahpsGllh.D.-lSshlhshsLhs..t.....................	0	22	39	46
+11630	PF11797	DUF3324		Protein of unknown function C-terminal (DUF3324)	Moxon SJ, Bateman A	anon	Pfam-B_7106 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function.	24.10	24.10	25.10	24.20	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.67	0.71	-4.46	23	905	2009-05-07 16:47:03	2009-05-07 17:47:03	3	3	246	0	66	605	3	142.20	31	41.83	CHANGED	sspslsIpNcYuYsIullLppsssp...lpPcLcLscVpsuphNt.+ssltAsLQNspsshlsplsl-ucVhppsscchLapscccslphAPNSsFsa..slsh.psp.......pLcsGcYpLchsspuscp..................pWcas+cFTIsucpAKclNcp	......................p.ppuhulpNcY..u..YslulhLpps.cpt.......lpPpLpLtcVpssphNu..+sslpsslQNspsshlsplplpuplhccspp.cslhpppppshphAPNSsFsa...slsh.ptp.........................tlcsG.pYplphpsp..sspp....................pWpap+.-FTIsscp.AcclNp....................................................................................................	0	26	53	57
+11631	PF11798	IMS_HHH		IMS family HHH motif	Bateman A	anon	Pfam-B_1349 (release 2.1)	Motif	These proteins are involved in UV protection, eg (Swiss:P07375).	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.25	0.73	-7.56	0.73	-3.60	92	4693	2012-10-03 02:11:09	2009-05-07 17:52:39	3	18	3144	158	842	3371	466	32.10	35	7.97	CHANGED	.psh.tphl..tsl.slpcl.GlGpphtpp.Lpp.hGl	.........tch..phl....tsL.PlpclaGlG+toscK.Lpp.hGI...........	0	246	500	691
+11632	PF11799	IMS_C		impB/mucB/samB family C-terminal domain	Bateman A	anon	Pfam-B_1349 (release 2.1)	Domain	These proteins are involved in UV protection (Swiss).	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.64	0.71	-4.20	106	7945	2009-09-16 12:11:34	2009-05-07 18:00:12	3	45	4183	220	2026	6312	2268	123.60	19	27.86	CHANGED	sp.lp...................pttt+olupppoh.st..sh...pshpplp......th.ltplspclsp+Lp....ppphh...............spslslp................l+........ht..........shp...phsc....phslsh.ssss.spp....lhph...shplh.......tph.hp.....t.....lch.lGlphsplt.....ptsptphsla	...........................................t............pt.pKSlusppo..a.sc.....cl.....pshp.phc.........th.l.p.p.ls.....pclsp+Lc...............ppp..hh......................................scpl..s..lp.................l+.............hs.............................................................................sap........s.ho+................phs..l......t...s....o....ps...sps............lhph........Ahplh.............tch.hp.............sts........lRh..lGlp..l..spl..........t..................................................................................................................	0	644	1225	1687
+11633	PF11800	RP-C_C		Replication protein C C-terminal region	Finn RD, Bateman A	anon	Pfam-B_4463 (release 6.6)	Family	Replication protein C is involved in the early stages of viral DNA replication.	20.80	20.80	21.50	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.29	0.70	-4.62	53	475	2009-05-07 17:07:56	2009-05-07 18:07:56	3	4	187	0	99	454	17	181.40	26	51.77	CHANGED	GsWpslpppapslhsplP.Rpsshsp..LcslhsclphLpp-ltshLctttp................spp.suN........-sps-+HhQNSsP-..uh.E.E......Ps..ppppt...........................spss..psppspspPh..............................+sh...PLuhVLcACP-ItsYussG.It...sWRDLhsAAshVRsMLGlSPSAap-AscsMG.csAAlslAsILpR..uspI.sSsGGYLRsLTcRAppGcFSlGPMlMALL..+sputs	..................................................................................................................................Wtthpthattlh.ttls..R..p...sshtp..Lt.lhsphpt.l+...ppl...phLctp.p.......................spphssN..........tspscp.phpsSpsc.....th.-.p..st...ppppt.....................................................................................................h...sl..shlhp.uCPpht.t...as.....s..t...ht........tWp-lh.tsA..hlR.hlGls.psaptAtphhG.ptAuhsluhl.hp+..........htpl..posGGYLR.hst+uttGthpht..hhuhhtt...s..............................................	0	12	45	63
+11634	PF11801	Tom37_C		Tom37 C-terminal domain	Wood V, Coggill P	anon	Pfam-B_30563 (release 22.0)	Domain	The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane [1]. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex [2].	27.00	27.00	27.10	27.20	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.11	0.71	-4.39	17	336	2012-10-03 01:14:49	2009-05-07 18:10:42	3	12	206	0	199	332	0	110.30	24	36.99	CHANGED	Ahhuhlpp+lpslhpYsLYlsscNYpphTR+hauphl.FPh.a.tP.ph+spApcpschlsl............................ptppp.ppc.sptsspls.Shhpchpth......Kppppp.l+p.t.shchhshLpchLsph................phlhuss.....oSs-hLhhualhlhhh.pLPss.hlhsaL+	.........................uhhuhlcpch.shh.ashalsscNY.phT+.hauphhsFPhpahhPsphpptthp+hthhth..............................................................................................................................................................................................................................................................	0	38	77	135
+11635	PF11802	CENP-K		Centromere-associated protein K	Wood V, Coggill P	anon	manual	Family	CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.	22.90	22.90	23.50	23.10	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.86	0.70	-5.16	5	82	2009-05-20 17:23:14	2009-05-20 18:23:14	3	3	60	0	52	68	0	210.10	40	81.50	CHANGED	MSt.pp-L.Ps..pDssssh-scEELL+ECEslWK-ME-CQSKLoLlGsETLs-SDAQLSLLlMQhKsLTAElcQWQKRsP...................EIIsLNcDVLL..sLGKEElQKl+pDLEMVLSolQuKNEKLKEDLEREQpWLDEQQQIl-oLsslpcElKNpVsThSESRIFsELpsKhhclKEaKEKLLosLG-FLEEHFP..LP-cptSscKKRKupp.-sSlQLITLH.........EILEILIN+LhslPHDPYVclcDSFWPPYlELLLRsGIALRHPEDPoRIRLEAFHQ	................................................................................................thpt.ll.ppCEp.at.hp..c..hQpcl..h.tsEshs.....pps....t...lhh.phps..LpuEhpphpccpP...................c.hhs.s..tlLh..tlu+cchp+lpppLEhlLSshpuKpccL+csLcREQpWlpEppplhp....ulp.h.pclp...p.ph.pho-.p.phh.p.....-hppK...hhphc......phcccLh.tLuchL-cHaP......L..Pct..sspKK+...+s..hp..csssp...hhslc..................-hlE..hLlN+hhcsP+...D...PYVpIsc.oaWPPYlEhLLRsGIAlRHP-Dss+IRLpsF.................	0	14	20	32
+11636	PF11803	UXS1_N		UDP-glucuronate decarboxylase N-terminal	Coggill P	anon	Pfam-B_36254 (release 23.0)	Family	The N-terminus of the UDP-glucuronate decarboxylases may be involved in localisation to the perinuclear Golgi membrane.	20.50	20.50	20.90	20.70	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.53	0.72	-4.22	5	56	2009-06-11 15:38:14	2009-06-11 16:38:14	3	3	38	0	26	47	0	67.40	63	18.26	CHANGED	Mlppthppll.oGlNRRMMKlLlALALIAYIASVWGsYlNM.RSIQEsGElKIE....QKI-EsVuPLREKIR-LEpSFTQKYP	.............pt...hlh.suhNR..hhKllhulAhhA.YlAoVWG.....NFVNM.....RSIQENGElKIE....SKIEEhVEPLREKIRDLEKSFTQKYP.......	0	2	3	9
+11637	PF11804	DUF3325		Protein of unknown function (DUF3325)	Assefa S, Bateman A	anon	PFAM-B_2004 (release 23.0)	Family	This family of short proteins are functionally uncharacterized. This family is restricted to Alpha-, Beta- and Gamma-proteobacteria.	26.80	26.80	27.70	27.40	25.40	26.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.39	0.72	-4.10	44	248	2009-06-16 09:39:29	2009-06-16 10:39:29	3	2	191	0	82	247	7	104.10	29	92.30	CHANGED	hlsshhL.uauuasuLuLAMp+Hacplh.s+ssss.sptphL..R....hhGWhhLslohhhsltshGh...uhGslhWhGhlohuulllll.hLsYp.......P+...hlhhhu.hsuslhu.........slhhhh	..........lhshsL.sasuassLuLuMs+Hacpl.........h..s+s..ss...tpp..phL..R.....hhGahhLslulhhsltspGh...uhGsVhWhGhLohuAhllsh...hLsap.......PR....hhh.hu.shsslhs.hh...h.................................	0	13	33	62
+11638	PF11805	DUF3326		Protein of unknown function (DUF3326)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2030 (release 23.0)	Family	This protein is functionally uncharacterized. It is about 300-500 amino acids in length.  This family is found in plants and bacteria.	25.00	25.00	56.30	38.10	23.80	23.00	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.93	0.70	-5.72	25	128	2009-06-16 09:50:57	2009-06-16 10:50:57	3	3	111	0	50	129	189	315.40	48	87.33	CHANGED	hs...slL.lVPTGIGCs..................IGGYAGDALPsARLLAussssLITHPN......VlNGAsLYWsssslhYVEGYuLDRFApG-huL+PV+ppRlGLlLDAuIEsEL+pRHLQlA-AsRATLGLslsshlhTDtPLtVpLptus.SGuSWGsl-pPDuLLRAucpLh.csGAsAIAVVuRFPDD.sotthptYRpGpG.VDslAGAEAVISHLlVRcLplPCAHAPALuPlsl.....sspLDPRuAAEElGaTFLsCVLlGLSRAPclls........sstspssslpus.plsAVVsPtGAlGGpuVLAsh-+...sl.P.lIuVtpNsolLpVoscsLGls..........lltlssYhEAAGlllAlRcGls.suLpR	...............hsslLIVPTGlGAt..................IGGaAGDALPlA+hluulsDpLITHPN......VlNGApLYWs.sNshYVEGYuLDRFAtGphuLpPV+p..N+lGLlLDpuIEs-Lt.RHlQsA-AsRAoLGLslschlhTDsPLplphphus.SGtShGoltsPDuLLRAscpLhppssApAIAlVuRFPDDsssthhptYRpGpG.VDslAGsEAlISHLlV+pFplPsAHAPALtPhsl.....ssplsPRuAAEElGaTFLsCVLsGLSRAPphlp...............tt.s....stsss.lhss.pVsulVlPtsAsGGpulLuhhpp...ph..s..lIsVp-NposhpssscpLslp..........shtVssYhEAhGllsAh+sGls.sulp........................	0	10	35	46
+11639	PF11806	DUF3327		Domain of unknown function (DUF3327)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2060 (release 23.0)	Family	\N	27.10	27.10	27.40	28.10	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.89	0.71	-3.81	35	840	2009-06-16 13:03:42	2009-06-16 14:03:42	3	6	641	13	81	482	3	128.80	46	31.19	CHANGED	pt..................hVTF............lWR......uss..............sshtlasshsultpp..........tpphpRLsuT.........DlW...................................ahohplPusaRuS................Yshhsssss.................hcsstcpthRtlhsp......upsDPLN.pshhsst........hhpttSsLcLssAsspsths	............................................................tsp.h..cVTF............hWR....s-ptS..............sl++ValhlsGVTD++psu......spsMpR.lsGT.........DVW...................................phThpLsAsaRGS................YsFlPstp-s.......................PDct.t..LRcGWRplLsp......AhADPLNspsatsGR..........GpssSsLchPpAPhQstW.s.................................................	0	13	32	60
+11640	PF11807	DUF3328		Domain of unknown function (DUF3328)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2062 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in eukaryotes.	25.00	25.00	25.20	25.00	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.96	0.70	-4.66	101	775	2009-06-16 13:12:53	2009-06-16 14:12:53	3	5	79	0	677	817	0	184.60	18	76.48	CHANGED	ptptpppttahhh.............hhhhhhhhhhshhhhhhthhhht..t.h.t.........................................h.h.........................s.....aps.sss...-h.-puW.............tshhlstpt....h.phshs.........h....st.............shhhtlp.saH....pLHCL.....................phlRptha.ph....................thtpss.pt.....................htHhpHCl-hLRQslhCpuDsslh....s..h............................stshss...............................hss...p+pC+sa..-tlhc..............Wspcp	................................................................................................................t......................................h...h....h.......................................................................h.....h...................................p.......a.....t...ss................ph.-ts...W.............................t....hh.h.stpt...............h.ths........................ss...................thhhtlp.saH.....pLHCL...........................phlRptha.th.............................t.t..t..tt.t....................................hhHh..pHCl-hLRQ......slhCpuDssl.......sh.hht...........tt.hss..................................hss.....HpC+.s..aptlhp..ahtt.........................................................	0	107	349	527
+11641	PF11808	DUF3329		Domain of unknown function (DUF3329)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2082 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.	27.10	27.10	27.30	27.60	26.90	27.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.06	0.72	-3.90	33	1029	2009-06-16 13:53:43	2009-06-16 14:53:43	3	10	1017	\N	175	598	65	89.50	47	20.74	CHANGED	hphsap.phltcLslhhlsslllGhlhGplshhLhlushshLsWHhhplhRLppWLapc+phs.PPpupGsWptlFsGlYRLQpRsR++Rpc	.......................E.RLoWK.+LlhELlLhslP..A..hl...lG....hhh...G....a.l...P...W..h..L..L...A..u..l..s..ul..L...l...W...Haa...sLl...RLShW..LWs-R..shT..PPsG..pGuWEsLhaGLaphQhRN++RR+E...................	0	29	76	127
+11642	PF11809	DUF3330		Domain of unknown function (DUF3330)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2077 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.	25.00	25.00	26.70	26.60	23.70	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.79	0.72	-4.11	9	204	2009-06-16 14:09:36	2009-06-16 15:09:36	3	2	158	0	20	76	4	67.30	73	44.19	CHANGED	sssMNssssosTSCCVCCKEIPLDAAFTPEGAEYVcHFCGLECYQRFpARA...pssscssstPs.ss.....sspP...os	................s.ssMNAN-PS.TSCCVC.CKEIPLDAAFTPEGAEYVEHFCGLECYQRFQ.ARA...pTATETslcPs.ACDS.PSs.........	0	6	10	15
+11643	PF11810	DUF3332		Domain of unknown function (DUF3332)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2104 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.	25.00	25.00	43.10	43.00	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.03	0.71	-4.61	25	244	2009-06-16 14:14:27	2009-06-16 15:14:27	3	1	223	0	47	189	10	171.90	36	95.19	CHANGED	+pphhtssshshssstLoGClGphuloshlh.chNl.....puVDNRYuRuGla..hlluPVYGlsssADhllFNSIEFWoGpNPl.......stc.PulsDs.s.cshh....clNsp.lctsLscsPlshh......pphcpuphphlDspshphplshssGpptpLhGh+.psspVshYl.DGchlsh............sohspLtshtpss	.........hhhhshhhhhuss..houChGphuloshlt.caNh......psVDN+as+EhlF...hlluPVYGlss.hADhhlhNSIEFWTGpNPl.......stt.ssVsDh.h..cslh....clNsp.lshphpcsshphp........+.hEpush..c.lpscshph.lshssGppph.Lhshp.ssspVshaL.sGchhss....lstptltuhhpss................................................................	0	10	21	37
+11644	PF11811	DUF3331		Domain of unknown function (DUF3331)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2106 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family vary in length from 96 to 160 amino acids.	25.00	25.00	37.00	37.00	20.20	16.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.37	0.72	-4.41	24	164	2009-06-16 14:22:22	2009-06-16 15:22:22	3	2	48	0	66	160	2	97.10	39	75.80	CHANGED	ttpsts.hsutssss...........thtlpllER.osoolhVpWsDss+C+YuEQpW+hshARpsGhCALSGpsIchGDsVa+Pph.R..shPsNusAMILAuslsphhst	..........................htss.........sshp........tsplpllER.SsoslsVpWs-ss+C+YGEQcWRtthAcpsGpCALSGpsIptGDsVa+Ptt.R..ssPuNusAMIhAusltt...st....	0	1	7	30
+11645	PF11812	DUF3333		Domain of unknown function (DUF3333)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2108 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.  This presumed domain is typically between 116 to 159 amino acids in length.	26.50	26.50	26.50	26.50	26.20	26.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.59	0.71	-4.23	62	456	2009-06-17 11:52:16	2009-06-17 12:52:16	3	4	432	0	116	348	598	144.50	29	36.69	CHANGED	hctpl++R.tAE+RF+haGluAIslulhhLslLLsoIlupGhsAFppThlplslplstpt.l-.ps.t.......ptltstsYtsllpsAltp....hshp.tst.st+thtt.llSpsAttpLR-hlhssPpllGpThshhlhAsucl...DshhKGps.s..tpshtps	............ctthK+R.tA-+pF+hhuhhAlhluLhFLsllLsSlhspGasAFpQThlhl.lphspts.ht.........................shlttu..sh.hlhpsultc....hsss..s.sp...t.p.chsp.hlS.pptthtlcchlhts.sthlu.pspshhl.usuch...D.hhKut..........s..........................	0	37	80	95
+11646	PF11813	DUF3334		Protein of unknown function (DUF3334)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2118 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family are typically between 227 to 238 amino acids in length.	25.10	25.10	25.70	45.10	22.00	25.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.52	0.70	-4.81	19	187	2012-10-01 19:50:22	2009-06-17 13:02:51	3	1	184	0	41	122	9	223.30	68	99.13	CHANGED	hppsplloT-DILLpLCpSVopVLosATpSpVpYSuMVQ+Is+TsLKPDlGCFVLFDGGFSGLVVINFSApAAhElYppYMLsMGMPcpELAhSHTSDEVuNVMGELMNQlVGDFTuKlp+ELQTsITQNQPKMLslNKQlhLSVDTNLDcPpARRVoFpTtpNpIFYLEhAMDKTEFIpLp-FEhcEc..DPDsLltppt......ttttspssssts..ttc............................s-sDDLLcpLGl	.........MpKsplVTTEDILLhLCpSVSsVLoSATsS.lpYSAMVQKIsKTSLKPDhGCFVLFDGGFoGLVVINFTAcAAlElYssYMRNMGMPE-ELAl.HTSDEVGDVLGELMNQlVGDFTNKVRKELQTsITQNQPKMLoLNKQVhLSVDTNLDRPQARRVTFoTsNNNIFYLELAMDKTEFIQL-EF-hp.E-p.sPD-ILttsp......ppp.p.spssssps..tpc............................ssusDLLDpLGI.............................	0	6	15	29
+11647	PF11814	DUF3335		Peptidase_C39 like family	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2152 (release 23.0)	Domain	\N	25.00	25.00	25.20	29.10	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.17	0.70	-5.19	25	210	2012-10-10 12:56:15	2009-06-17 13:04:35	3	5	202	0	49	172	23	201.10	47	55.40	CHANGED	lPaYpQTT-FTCGPAsLhMAMusLcspht.spppELplWREATTIFMTSGHGGCuPaGLALAAh+RGacsclalsssusLFlDuVRsppKKpVhpLVccsFtpplpppsVslphpshohpclcptlspGttslVLISoYRhsGcKsPHWVllouhD-calYlHDPcl-.tpppcsshDstalPIu+p-Fs+MupFG+s+.LRAAVllppp	...hPaYhQTTsFTCGsACLLMAhus..L......c....t..shp.oRspElpLWREATTIFMsuGHGGCuPpGLALAAtR......R..Gac..V-lhsssp.u....s.FlD...uVRsssKK.......pllcLVHpcFsppLsppsVshh.tssstspLcphlpp.GupsLlLI..SoYRhsu..c.K..tPHWVllouh....s-.cFhalHDPc............s-................pc.....cpsh-stalPVu+ushsphhsFG+p+.hpAsVllt.p.............	0	15	30	42
+11648	PF11815	DUF3336		Domain of unknown function (DUF3336)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2157 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in bacteria and eukaryotes. This presumed domain is typically between 143 to 227 amino acids in length.	25.00	25.00	27.90	27.00	24.80	24.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.68	0.71	-4.68	82	500	2009-06-17 12:07:04	2009-06-17 13:07:04	3	5	249	0	353	491	21	145.30	26	20.75	CHANGED	thhcpp...hhp...........pLhcphcs........................upoYc-WhpsAtpLDch.....hGtstW+.psspss..hYDaphlppplppLcpsRtps-h.........................................ppLhhllcsslpRNhuuh...ssspLYp+oah..GTKpLI--YlcElttslphlscs....pplssp...phhthhppspps	..................................h.............php....pLpp.phcs............................Apo..Yc-WtpsAtpLDch.....hGt.stW........+.....psspos.......hYDhpllppplppLcctR...p.ps...-h............................................pplh...h...ll+s.s....lhRNhu..sl......sss.pL.Ypcoah....G.T......KpLI-cYlsE..lt..psLchlspt............pphs.p...thhthhppht................................	0	100	200	307
+11649	PF11816	DUF3337		Domain of unknown function (DUF3337)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2058 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.	25.00	25.00	26.00	25.30	21.20	24.60	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.04	30	297	2009-06-17 12:16:39	2009-06-17 13:16:39	3	23	247	0	215	309	1	296.90	26	35.92	CHANGED	ptshssppphhspp...........sssssshhshsps..tthpssupss.ptt.t...........stsPst.shs..tppsphssohhs.cchch....s.h.tc.ttt.pt......................ptstppspppp.hc.shuuhltpshppa..pphtssst........................sphpPs.ttcss.hh......plPscoslllpE..sstusspslaRt..plsshspct..........-hlp...cslPhWluchLLcNphP.K.-s.sKlsFhLpPa..............c.....................sthPshscs-.................................sssRLsAscMLRs+KIhsYVsE+l......sps.....pp.pspt...............................................................hcPc-aLELhCps..................pl..Lss...sMTLuTlRshlWKouuDllLpY+tpsc	.......................................................................................................................................................tpp...........stttsthhsh.ps......hhhps.up.ss.ppp.pp.....................s.hPshhsh-....cpuhhshsh....cc.ph......h.s.h..........................................................ttst.sstptp..s..c.Nhsshl.phhhca....pht.ps.p................................................................................tsphp...s.ss.....pp......tss...hh..................plP.....scosllhtE..........uust.slaRh..hlpshss-t.......................-...h.........cshP.Wlh-hl..l..psp.h........P...c.....sKlsFhLpPa................................s.............sshsphh.pts................................................RLsAs....cMLpl+K.lhtaVhE...+l.....st.ps............................tp.ptst..........................................................................................................hhs--hlELhCps....................pl..Lss...sMsLtTl+palWKs..us..DlhLpY+tp..p..............................................................	0	69	121	179
+11650	PF11817	Foie-gras_1		Foie gras liver health family 1	Coggill P	anon	Pfam-B_4417 (release 23.0)	Domain	Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease [1]. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first [1]. The C-terminus of this region contains TPR repeats.	23.30	23.30	23.30	23.30	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.44	0.70	-4.90	22	379	2012-10-11 20:01:02	2009-06-17 18:05:52	3	16	226	0	279	399	0	215.80	20	20.99	CHANGED	+h.-s+hluDhlsh+I................hRhhLhsupss..sAlppaptHhp+hp-h......lsp.h.ut......t..tatuW.uR....htlhA-Llcpsshsthsshp...................................sGaahppAAc.ahhtR+phtpph.............P........pssuuplhsphahhcsh............sspsppthshsts..pthsHSt.IlshLppAhtpFpphpp...........sRhsptLsh...chAcEYh+hs.sascAhphlcsl..shsaRp-sWhsLhpchhhtL+cCAhphtDscshlpsshELhsh	......................................................................................................................................................................................................................................................ph+.hhthhth+h.................h.chhh.....tps....tAhtphptHhphhtph.........................hs.....p............t..th.sW.up....h.hhuplhpps..................................................................................................suhhh..uA..hh....+pthht.h........................................................................................................................t.h..............................................t...th..............t......h..psthhlphhp....pAhtpapphtp.........................Rhtphlhh.....phucpa.ht.ht..pap...pAhphhp.h....hhpa+.........pEtWh.tlhpphhhthhcCthhhsphtshlphshchhs.t.............................................	0	81	141	219
+11651	PF11818	DUF3340		C-terminal domain of tail specific protease (DUF3340)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2330 (release 23.0)	Family	This presumed domain is found at the C-terminus of tail specific proteases. Its function is unknown. This family is found in bacteria and eukaryotes.  This presumed domain is typically between 88 to 187 amino acids in length.	28.60	28.60	29.40	29.20	28.30	27.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.63	0.71	-4.23	98	1144	2009-06-18 09:33:45	2009-06-18 10:33:45	3	5	1125	0	222	767	468	142.30	45	20.88	CHANGED	ohl-st-hGEss.-NALPWDpIssApYsphsshssh...lspLpppHppRlspss-Fthlpcclphhcpp+-c.pslSLN.spRctEpcpt-pp..pLpth.......NpRhp......t.tG..p....cslpsh.........................-.........................................-h..sc-h.........tt.Ds....aLcEuspIhhDhh.......phpp	.....p....tsEsGEphEDNALPWDoIc.u.As..Y.s+s...sc..ls...sh....hscLhccHpsRIAcDPEFphIhcDIAcapsh..KD+...shVSLNhutRccEssccDup..RLsRl..................N-Rh.K.........p..cG......K...s.LKcL........................D..............................................................................Dl....PKDY...............pcPDs......YLDEolpIslDhscl..p............................	0	60	117	178
+11652	PF11819	DUF3338		Domain of unknown function (DUF3338)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2474 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.	34.60	34.60	35.40	35.30	34.10	34.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.59	0.71	-4.72	8	236	2009-09-11 14:35:59	2009-06-18 10:36:45	3	8	64	0	127	216	0	132.30	48	17.22	CHANGED	hEuKsclIsuSSGolluSGStsu-sS.csKKE+lpsLKcKpcsLc-+Lpt+LcELKKlCLREA........................ELTG+LPsEYPLpPGE+PPpVRRRIGTA......FKLD-..lLs.sE-stLpsLEschAlQQQIsEAA++LusEscLSKsl	.................................tuKsplI.sSs.GolluSG.u...pu-s.ut.psK...+.-hltsL+p+pcsLpEpLpp+lEELK+lCLREA........................ELTGcLPtEY.....P..LcP.G...Ec.....PPpVRR.RlGTA.................FKLD-...pl...L.....s.t..tE-...stLp...pLEpchulQppIsEAA++LAs-PsluKp......................................	0	17	30	65
+11653	PF11820	DUF3339		Protein of unknown function (DUF3339)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2694 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in eukaryotes. Proteins in this family are about 70 amino acids in length.	25.00	25.00	36.80	25.60	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.39	0.72	-3.68	25	199	2009-06-18 09:40:15	2009-06-18 10:40:15	3	5	29	0	126	175	1	66.80	52	81.93	CHANGED	MsDWGPVlluVlLFVlLSPGLLFQLPG.+sRhVEFGshpTSGhSIlV.Hslla...FullsIhllAlplH....lYs	.......MuDWGPVllulVLFlLLSPGLLhQlP.G..+.sRhV.EFGshpTSGhuIlV.Hulla...FuLlsIhllAlslHlY..................	0	16	74	100
+11654	PF11821	DUF3341		Protein of unknown function (DUF3341)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2731 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in bacteria. Proteins in this family are about 170 amino acids in length.	25.00	25.00	25.20	26.50	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.02	0.71	-4.79	37	213	2009-09-11 12:21:10	2009-06-18 10:43:59	3	3	197	0	114	226	320	170.60	31	77.66	CHANGED	tptslhA.Fscs-sLlpAs+plRt...tGa..phh-saoPaPlHGLDcAhGl.t.oplshhshhhGlsGsssuhhhphahshhD..........aPhsI.GGKPhh..Sh....PAFlPlsFElTVLhAAhuhlhuhh.hhstLs.hp+Phh.ss...+socD+Fhltlsssss...-tpchpphLcphGAhclphlp	......h..hslhA.Fsss..-sLlpAs+pl+p...tGa..chh-...saoPaPlHG..L-cA.hG....l..tco+....lsh..hshhhG.lhGhssuhhhthashhhD.................aPhsl.GGKPha..Sa....PuFlPlhFElTlLhA.Ahshllshh.hhspLs.h.t+shh.ss.....R.s.ocD+Fhltlpspss....stpphpphLcphGAhclp...t.................................................................................................................	0	54	88	104
+11655	PF11822	DUF3342		Domain of unknown function (DUF3342)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2751 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in bacteria. This presumed domain is typically between 170 to 303 amino acids in length. The N-terminal half of this family is a BTB-like domain.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.32	0.70	-5.29	9	124	2012-10-02 01:20:04	2009-06-18 10:46:24	3	4	99	0	82	233	4	273.00	41	42.62	CHANGED	s.IpVpDcspNppRsFpCspcLLhocMpYFssllph.................................................................sspch............lsIpV+CDlpIFsWLMpalct.................ctPplsPsNVVSIhlSSsFLpMppLl-psLtYh+t+LsplVtousNhsClsspLlsRLusMhscs-Lst....l+Dc+schps..+lhspLIp+.LC-..sps..............................ts..uph.....suLhhCthCtpLhsppp.p+lpp.........sPu....................+hslspRGclhhoHsts+..................shsspta..lsshpcELcuWt...WRlhGuhpalhCpRCpphhslh-ho..pCphtPtshsassssup.Dstu.suhashC.tppshca-	................................................hlIHVCDEsK.shpcDFhCPpcLLlscMpYFA-hl...................................................................s.u.Q+h-E..........lDIS.VH.C.D.lpI...FsWLhpal++s...............................................................tttchPp.L..-ssNVlSILlSSpFLpM-.sLl-pClpYC..Hpp.hs.....tIVt..ossNhsClsssLloR...........lAshFoptEl-t....l+DKK.DKhpS..+LasKhIpp.Lh-sp..s...................................cu..ssh.....usLa..RCshC..tpllspphpp..plsC..........hPu....................phplsp+Gplh..hHh.RD.p.............................................................sWslppY..l..sLacEL+SWRc.....VYWRLWGshpaL.hCspCtphF.sh-hs..aCpaHscss.a.ssssp........s.sGhYsCC.sppshRa-.............................................................................................................................................................	0	32	41	62
+11656	PF11823	DUF3343		Protein of unknown function (DUF3343)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2956 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 78 to 102 amino acids in length.	25.00	25.00	25.10	25.00	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.04	0.72	-4.72	58	857	2009-06-18 09:51:36	2009-06-18 10:51:36	3	6	709	0	160	521	6	70.90	27	76.57	CHANGED	ptphlllFpospcuhpsE+.....lLKcpsl.shcllPsP+pl.psu..C.Glulchst.pp.tptltphlpctslthpt....laphp	.....................calhhFpoTstslpsc+.........................hLps..t..uh.sh+lh..slPR.cl..puG...C.Glslhhs.....s.ss.t-clphll.ttt..hpsla.....................................	0	90	133	147
+11657	PF11824	DUF3344		Protein of unknown function (DUF3344)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3041 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 367 to 1857 amino acids in length.	27.20	27.20	27.50	27.50	26.20	25.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.88	0.70	-5.02	42	118	2009-09-11 16:28:30	2009-06-18 10:53:44	3	42	17	0	94	122	4	276.20	22	40.86	CHANGED	ssshsss..a.Gst.....s....Lsohtp..ssV.....pGslhhss..........hhGhssps..............spsh....slP.su........slchA+LYls.sWst.........ppsh.sphslsFNG..........ppht.........................ssts.Ysshps......assh.p....shas.YDVTs...hlss....G..psssslss...........sshcG.....plhussLlllYc.ssstsphp.YWlN-GsDhlph...............sscpssups.Fsus.ss.s..lpsAsLhohhhoustt......sslhFNu............sslhsus............................pushhshp.tasVsshlpsspNpshh.s............tsssYhpsshulLslch	......................................................s.....tt..a.us......s....lsohtp..ssl.....pGslhhss............h.uhssps...............spsh.....slP...ss......s.....slphA..+LYls.sWst.........pssh.sshslsFNG...........................pth.................................sssstYhshss...........ass.hhs.sh.shhh.YDVTshlps.....u.pssh.slss............tsshcu......plhshsLllsYp.ss.sssphp.halN-GpDhlsht.t...............tscpssups.sFsss.hs.t..tlpsApLhshhhuu.s..s.........ushhFNu....................pslhssss.................................pus.hshp.taDV..ssh...lps..ss..spshhts................tsushhpsh.uhLslp...................................................	0	50	62	72
+11658	PF11825	Nuc_recep-AF1	DUF3345;	Nuclear/hormone receptor activator site AF-1	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3322 (release 23.0)	Family	Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [1]. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [2].	27.30	27.30	27.30	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.83	0.72	-4.15	14	198	2010-01-08 15:29:35	2009-06-18 10:54:52	3	5	47	0	73	155	0	100.60	44	24.06	CHANGED	uoSlssssths.hss........Hssh......sshss.t.h....osluSP.lNulGSPaSVIo.SolGssShulPuT.PulGassh.SPQhN...shs...uVSSSEDIKPP.GLpsl......phsspusGuh	.........................................ss.ts......s.HPSh......sshss.t.l.....SsluSP.lNulGSPasVIo.SuhGs.uh...slPuo.PuluaushsSPQl...NS.....shN.........uVSSSEDIKPP.h.GLpGl.....hphsupssGsh.............	0	2	10	30
+11659	PF11826	DUF3346		Protein of unknown function (DUF3346)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3462 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 231 to 659 amino acids in length.	25.00	25.00	37.30	36.50	20.00	16.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.47	0.70	-4.57	4	170	2009-06-18 09:56:55	2009-06-18 10:56:55	3	2	126	0	11	121	0	220.10	88	43.69	CHANGED	FTDFQLHELTGRWLSEN.MPEGFKSDRFRFLARTITASEEAPpEGpDGEIRIKPNLYILVWEPSFa-ELLTRDYFF.LFPPEILKQHTLVFQLYSFFRSRMuRRhTDsMLLSELNQKLARNI-WRRFShDLIRELK+LuEGKsoE-lFlVNLWGYHLTIpuh-pstKlsDYQIDI+CDs-E.VlRYSRA+TTNsGKRsM.APThPNPLRNElhsKQcL-pLSuIIDGEF	.............................................FTDFQLHELTGRWLSEN.MPE...G.FKSDRFRFLARTITASEEAPsEG.SDGEIRIKPNLYILVWEPSFaEELLTRDYFF.LFPPEILKQHTLVFQLYSaFRSRMuRRHTDsMLLSELNQKLARNIEWRRFSMDLIREL+R........LS-G.KGoEDLFVVNLWGYHLTIcoh.EcGKVhDYQVDIKCDVEE.VLRYSRA+TTNAGKRNM.APTLPNPLRNEhVoKQpLsELSuIIDGEF............................................	0	1	3	8
+11660	PF11827	DUF3347		Protein of unknown function (DUF3347)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3580 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	25.00	25.00	38.70	38.70	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.35	0.71	-4.27	46	213	2009-06-18 09:58:49	2009-06-18 10:58:49	3	7	83	0	98	245	40	172.30	25	54.87	CHANGED	hshh...hhhsusppppcpp.h.....................pthtttt....................tphthsphtspphpplhssYhplKsALVss-sppApssAppLtpshpshshp.......phhspttpphtphh...............slcpQRctFptLSpphhshlcts...hsssslYhpaCPMA.sscGA.WLSpsccI+NPYaGcpMLsCGpVpc	....................................................s............tt.t........................................................................................tt.thstttppphptlhssYhplKsALspsDsptApssApplhpslpt.lshs................thts.ptt..pphhphhpp.h.tt................tclcpQRp.tFptLSpshhsllcth.....tsspslYhpaCPMsp.sspGu.WLSp..sc..c...l+NPY.......aGspMLsCGplp.........	0	47	84	95
+11661	PF11828	DUF3348		Protein of unknown function (DUF3348)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3615 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 244 to 323 amino acids in length.	25.00	25.00	25.10	98.20	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.52	0.70	-4.95	19	133	2009-06-18 10:49:21	2009-06-18 11:49:21	3	1	131	0	44	153	14	243.60	46	94.84	CHANGED	MsQsPpRsshuGPsLlRLLARLsss-sspSppuLu-RLSQWLsWoDAlALSuA......LsupsPssssuspssusstc.....-tARlRusLspuIsscts.ts.tRtts....h.hsshssssp.stsDaAsaRQpYLuhQpsMcssIusLRGRLRstLAuposs.hARLAhlDAlMEpsLusRERsLLAslPsLLts+FERLRpsccts..ststss...........................hstsGuWLssFRpDMQSVLLAEL-lRhQPV-GLLAALRsp	..........................Mhpss.RssLuGPsLlRLLARLscs..Dls....tStpuLuDRLSQWLuWTDAIALSuA......LsussP.us..s..s.....u...s..cst.utstc....tpsARVRsuLApAIssssshhs..sRtts.........pssshss.s..ss...sss....DaAsFRQ+YLuhQQsM-sslGpLRGRLRptLAsposs.hARLAslDAlMEpsLusRERoLLusVPsLLus+FERLRcAcptsh.t.ts.t.st.sts............................................................sssPsuWLDsFRcDMQSVLLAEL-lRFQPV-GLLAALRsp.	0	6	19	32
+11662	PF11829	DUF3349		Protein of unknown function (DUF3349)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3716 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.	25.00	25.00	28.80	28.80	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.25	0.72	-3.56	24	263	2009-06-18 10:51:17	2009-06-18 11:51:17	3	2	128	6	68	170	2	97.70	43	87.82	CHANGED	hsshlsslluWLRAGYPpGVPssDhhsLLALLpR+.Lo--EVptVAppLhc..pup.s.......spsDIsshIsplTcc.PsP-DlcRVpA+LAutG.....WPLssscp	.........spalpSllsWLRAGYPEG.VPssDphsLLALLpRp.Lo---lppVs..pcLhc....pGs.s...................Dp.-IushIoclTcc.PuPEDlpRVtu+LAAtG.....WPLsss.c..............................	0	14	42	58
+11663	PF11830	DUF3350		Domain of unknown function (DUF3350)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3789 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 50 to 64 amino acids in length.	25.00	25.00	29.50	30.70	22.00	18.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.84	0.72	-3.94	11	178	2009-06-18 10:57:16	2009-06-18 11:57:16	3	7	70	0	79	164	0	57.80	56	5.47	CHANGED	-lsPpusLSPshttt..........tssttct+RoscELRcLW+pAI+QQILLLRMEKENtKLp	.............................EL.PhSPLpPshE-t..............ss.t..pcc+RsScELRpLW+KAIcQQILLLRMEKENQKLp.	0	13	18	42
+11664	PF11831	Myb_Cef	DUF3351;	pre-mRNA splicing factor component	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3985 (release 23.0)	Family	This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.	27.00	27.00	27.60	27.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.63	0.70	-5.14	29	298	2009-06-18 10:58:48	2009-06-18 11:58:48	3	12	252	0	217	288	1	227.90	29	30.07	CHANGED	TPNPlhos.hppst...............thGhTPhpsh..........GtTPh..pTP...RDphslN...........tt.....htpospph+hp.pppt+ppL+suLuuLPpP.cN-aEl.lP-pt......pp-.scptEp.....h...EEDuu-t-tRc+ttcptpcptchc+RopVlQRsLPRPs.lsht.Lh..............phssp..s.sccllpcEhhtLlppDsh+aPh...sssp..ttp............................t.th-phs-stlppA+thlptEht..h.................t..sppppphc............sasps	.................................................................................TPNshh..os.hRp.s...................t.uhTPtts............utTPh.....pTP..........hRDphsIN............ppt...........stss......P.p....+.t..ppph+pp....L+tuLuuLPtP.cN-aElslP-pp...............ppE...pptct..................h....EDsu-h-tRppttc-tpcttEh++popslQ+sLPRPst.ls.phLh...................................................p.s...st..hppu-cLIpcEhhphltaDsh+.a.Ph...sssp...ttp.................................h..h-phscppLp..pApphltpEht.h............................t.t......................................................	0	74	117	174
+11665	PF11832	DUF3352		Protein of unknown function (DUF3352)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2160 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 538 to 575 amino acids in length.	26.80	26.80	27.40	26.80	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	536	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.62	0.70	-6.20	32	156	2009-06-18 11:54:13	2009-06-18 12:54:13	3	5	102	0	59	174	55	465.90	18	84.34	CHANGED	slhuushlLlshusuhaahhtpp.psl.hhpps.hshPhuAphlPpsA.lslplhssPscl.shtphsss.pp+pthppthpp........h+cshhAtsGlcapp-.lpsWlGsplolAllss....s.sp..................tpsuhlhsLssc-sptA+pFLpph.appcshsG.sslphpsY+Glplhpspsshht.............shusAll..s-p.hlLlAss.tllcpAlDshQhss.shtus.thppslppL..scs.lAhlhh.s.ssht.......pa........hpl.spslsphp.slpullsulshpspuLthcuhhhhpsph.....sss.sps.....Lpphsusshhhlu..........sLpp.appls........psss.hsphlp.lhpphhpthshslspslhsh...pGchhh.hlsts..........suWlhsspppsssss............p..LDphhp.spG.hphsslshsspslssWop.........................................L.h..t.t.........ltsp........lsss...........+uthsspthaussLsulspthss.....tpsLtss.phppslssh.....tsstt.hhLshptstshLsp.hhPh........hhh.hthsupslhsslpululss...........................tss...ssshhphchhLplt	.......................................................................................h...hsshhlhshuhushhhh.tt........ts..p....sshhlPppA.hhhph.sss..pphtth.....tphhs.......ppppt.......hppthpp........hppph...hst.ss....lsapp-..lpsWlGp.clslA..lhs.shpt..........................tpsshLlslshp..ctptucphl.pphhppps.ts.hplp.pppYpGlsl..hthpsstst......................h.ssAll......scp..allhuss.pl.lcpAI-shpsss.slsps..sappshppl......sps.luhlah.shssl....................................phh................hsh.sp.hs.ph.p...thp......shs.....hulshptpulthcshh....hhpss.......................s...st.......hlph..hsspsh.hh..hs........................................slsp.a.pt.htp.h......ttss.h..phhpphhtphpp.hslsltpslhsW..hpGEauh.hl.pt.t............................tsshlhhsptp..stt.............t..lcthht..ptt..h.htph.h.tt..l..Wp....................................................................tt.....................h.hh...........hs..st..hhht.htshtth..........sl.tp.th.p.h.............t.hhlshp.....h..t.....s...................t.hh.thpulshs...............................ttt..t.phhh...........................................................	0	17	45	57
+11666	PF11833	DUF3353		Protein of unknown function (DUF3353)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2231 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 205 to 258 amino acids in length.	28.40	28.40	29.30	28.60	27.70	26.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.22	0.71	-4.85	34	209	2009-06-18 11:57:17	2009-06-18 12:57:17	3	4	100	0	110	207	132	176.70	25	71.90	CHANGED	sp-ASFEElQpARsphLpph.usDtpspsplEAAYDulLMppL+pRQpG+ltlsptlphscp...........tsssstsstsssshlpch................s.lshPpspslhhphsh.GsLullhllh.........s..ssssspLhLuluhhuslhhhh++...tp+hhpuhhholssLhlGlllGullsshl.s.hls..hshospplpulsshllLaluuhhL	.............................................psASa-EIp..tA..+shllpph..sscppshtp.........lEuAYDtllMppLpp.RppG....Kl....plspcl+hsc......................stssssWlpph......................hp..h.Pstp.sl.hhphhhauhlsshslh............s...stssssh...lA..luhh...uslY.Flp.c.+............tp.phh+uhhhshssL.hhGhhhGshl..shl.s.........hs.p.h.uhhshhhhalss.aL................................................................................	0	26	73	98
+11667	PF11834	DUF3354		Domain of unknown function (DUF3354)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2265 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 60 amino acids in length.	29.60	29.60	29.70	29.90	29.20	29.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.41	0.72	-4.36	43	290	2009-06-18 12:00:32	2009-06-18 13:00:32	3	39	100	0	145	279	0	67.50	36	10.74	CHANGED	hhRVoIa...sspc....spts.GKLlhLPsSlcELlcIuupKFGh.s.s.ocVhsp-.GAEIDDlclIRDGD+Lall	......................tRVola..tsspp.......t.....GKl.lhlP..s.olp-LlplAupKhGh..t..s....opl.hstc.GucIDDIslIRDsD+Lal......	0	25	77	113
+11668	PF11835	DUF3355		Domain of unknown function (DUF3355)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2268 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 111 to 177 amino acids in length.	26.70	26.70	49.10	49.10	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.13	0.71	-4.43	5	57	2009-06-18 12:04:15	2009-06-18 13:04:15	3	2	3	0	21	51	0	152.20	44	28.56	CHANGED	TPTKCSTPVPSsAITKuVAESTPTslEHVFPATsusSsPSIuSAAtsTPVSLTtTKEAEADMsKVE-Ko-cTlpDLCsK....INpMLEsp.....E.hhusDSTtsVslhussTsssshsLEhsp-..App..h.phsppp.hs.hps.............ssc..hspc-hltthclsoK	...............hPTKCSs.sPSsATT+ssAcSosss.E+VFPAThus.sPSssSushsTsss.sETccs-usMDKs..ps-cThQDLCs+...............IsphLEshRshK.-.ohShD.stslsshSsNsssss.........hhhEVSsE..AsshphVsoschshssshps...tp..p....ssst....sMsp--hhchhcVsoK.........................	0	0	0	5
+11669	PF11836	DUF3356		Protein of unknown function (DUF3356)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2406 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 104 to 119 amino acids in length.	26.90	26.90	29.00	28.20	26.30	25.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.07	0.72	-4.21	42	205	2009-06-18 12:07:32	2009-06-18 13:07:32	3	2	175	0	72	166	41	99.10	39	86.19	CHANGED	apGEV...........slslsGpppsh+LTLGALAELEsthus.....ssL.......suLspR...Fcsup.hSu+DlltllsAGLRGGGhsssps.-lhpspltGGsh..ss.ucsAApLLspuF..shs	................hRGElshplsGccasLp.L.TLGALAELEsshts.....ssL.......sALltR...FssG+.hSuRDlhplIsAGLRGGGpsss-c..-lushps...cG.G.ss..uh.AplsupLLsssF.ss..s..........................................	0	17	48	58
+11670	PF11837	DUF3357		Domain of unknown function (DUF3357)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2464 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 96 to 119 amino acids in length.	27.80	27.80	27.90	27.80	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.59	0.72	-4.20	35	152	2009-06-18 12:11:01	2009-06-18 13:11:01	3	4	62	6	22	158	0	103.30	29	16.65	CHANGED	hsshshp.YsP.LPssstsss.s...........+RRsh...pshsslhsullhLhhllull.............sspssssst...sss.ssspssss..............SRGsspGVSEKSsss........hsus.ssuFsWoNuML	...................s.....t.YsP.LPsssssutt............++R.......tshsslhsushlLhslsshh................stssss.ps............tss.pssts...............SRGsspGVSEKosss............hhuu.ssuFsWoNuML...........	0	2	11	17
+11671	PF11838	ERAP1_C	DUF3358;	ERAP1-like C-terminal domain	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2558 (release 23.0)	Domain	This large domain is composed of 16 alpha helices organized as 8  HEAT-like repeats. This domain forms a concave face that faces  towards the active site of the peptidase.	23.90	23.90	23.90	24.00	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.01	0.70	-5.19	123	3372	2009-06-18 12:17:03	2009-06-18 13:17:03	3	33	1415	15	1516	3073	300	295.80	18	35.56	CHANGED	hlhlNssshuah+lpa.sscphsplhp............tltpht....sshsRshlhusshshsps..........GphsspshlsLlp.....th.....ssEs-.......hsVhspllsplsshttshh.hpspttpp.hpp...h..plhst.hhcpl.uhp.s...........sshphthl+shhhssus.........ssts.hphhpshls...G.sps............slss-LRhslhsslstt.Gs..tpt.....hpplhp.hppss....................o.....sstcptAlpuhuthsssplhpc.shshlhs.....s....s.lp....sps.lthshtGh.............t.sspp..phlhsahpppa.-pltph......hsstss..hhshhltlhssth.......s..........stctlpplcpah..p...........sct...stuhc.Rsltpsh-slp	..............................................hlhlNssph..uaY+lpY..cspth.pt.lhp.........................tltt.p.................l.s.s...h..sR.stlls-hhslscs..........upls.hsp.hlsl.lp.....hh......tp.Ess..........hhsh.ps.hh.....p..t.l......s..h....ht.hhh......t....s....s..t..hpp.......hpp...........................hh.p.l..hpt.....hh...p....p.....l...uhp.st.................................................psh..t.pt..hhR..sh.hh..shss....................t..ts...hppu..tph.h.p.t...ahp...........s.....s.......................................slss.s...lR...h..l.htshhpp...us....tpt..........hshl.hpph.p..p....ss...................................s.....ss.t+pph.htAL.....u....s.s........p...........s............st.h..l.pp..h.......l..p.hhhs......s............p.....lp.....sp-...h.hthh..t.s.h..................h...ssths.phhhsah..p..p.pa.p...h.l.ph........h.stts........hsthl......t.h.hsph.h.t...................stp.p.htphctah...p............t........................................................................................................................................................................................................	0	434	694	1236
+11672	PF11839	DUF3359		Protein of unknown function (DUF3359)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2625 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.	28.40	28.40	28.40	28.40	28.00	28.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.26	0.72	-3.65	2	169	2009-06-18 12:27:18	2009-06-18 13:27:18	3	1	117	0	29	87	0	84.90	74	98.60	CHANGED	MpplL.hSulshuulLAsGCuSlocp..............sEttlouspssAspu.uRAsEAYtKA-EALAAA.tAQpsAsEANE+AhRMLE+AShK	..................MNNVLKFSALAL.A.A.VLATGCS.S..sS..K..E........................TEARLTATEDAAARuQARADEAYRKADEALAAAQKAQQTADEA...NERALRMLEKASRK..............	0	8	13	23
+11673	PF11840	DUF3360		Protein of unknown function (DUF3360)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2754 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 489 to 517 amino acids in length.	25.60	25.60	26.40	27.10	25.00	25.50	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.75	0.70	-6.16	11	257	2009-06-18 12:32:27	2009-06-18 13:32:27	3	2	199	0	48	167	14	447.20	65	98.72	CHANGED	MSss........................ppsSYpclH+PuSEFpTR--YL-HELpIMpPKRW+lNLPhRDaRFEhEDhVPAhAATIGKlVMVuAlsAAFAush.......GLusEFVlENVRYELLIAulLFVILhSGFLNPsANLAGTHGPhIPLIPlIsAAGGHPLALGIhlGlFGLlLuloKGGShLspLTScGVsGGLLlYLGFlGhhSQlpKLhuWAsuh........uMualuFVVIhsTIllYAhLt+hpKRWLAIPLsullAullAFuMGAPF-..FsTpPGLPNhsPhYWWGE.sTGWpLGLPslpHFIAVlPFAlLAVAMWSPDFLGHRVFQcLNYPK+u-+VLMslDDTMTssSlRQhVGSlLGGGNluSSWGTYMIPAAIAKRPIPGGAlLTGlhCllAAlhGYPMDLAlWpPVLsVALlVGVFLPLLEAGMQMsR-sKsoQSAuIslFuSAlVNPVFGWALTMLLDNhGLIGsKERuspLohhcRhlIPsssFllhsuuMuhVGMLP...GIPAlL	..........................-h.cspoYc-LHRPuSEFtoRs-YL-HELQIMpP+RatlNLPhRDaRFEhEDhlPAh.AGTIGhlsMhuAlhhuaAssL.......sLu.cpFslEssRhEhLIsAl.FsllhSGFl.PpANLAGsHGPhIPLIshlshAGuHPLAhuILlGVFGLlLuhhKGGShLssLTSpGssGGLLlaLGFsGThuQlppl.pWAsGl........sMuYIuhlVlhlsIllYAhLt+hpKRWLAlPlsshhuhllAhALGAsF-..FpTp.GLPNhsPsYWWGp..ppGWhLGhPshpHFlsslPFAlLAVAMWSPDFLGHplFQclsYP++TEKVLMslDDTMThCSlRQhVGohLGGuNhTSSWGTYhlPAAIAKRPIPuGAlLhuhLshhhAlhGaPMDlAlW.PVhpsALlVGVaLPLLEAGMpMs+csKs.oQuAuIslFuSAlV..NPVhuWALTMLLDN.GLIGsKERuupLShhs+llIPusshlIhhhAMhAVGML....Gl.Ahl........	0	10	18	34
+11674	PF11841	DUF3361		Domain of unknown function (DUF3361)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2780 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 154 to 168 amino acids in length.	27.20	27.20	27.60	28.50	27.10	26.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.92	0.71	-4.52	9	228	2009-06-18 12:35:40	2009-06-18 13:35:40	3	3	88	0	122	212	0	153.90	50	23.12	CHANGED	hTFAtEFIpccGLthLhpllEsusc............hu............-hLsasLoAFlELM-HGhVSW-hLosoFI++lhuaVs.psth.csollppuLuILEshV.sSsslathVtpElTltpLlphLps.sspplQspAIALlNALFlKAs-s+Rp............phAsslupKpl....RthIhssllt	........hTFApEFIsh-...GltlLsp..hVEsGoc..............hu.....................................-hL.uaoLTAFlE.LMD..H.G.IVSW.D.hlSlsFIK+IAuaVs....pshh..DsSIlQ....pSLAILEShVL.N..........SpsLYppVup.EITlspLIsHLQs....osQp..IQThAIALINALFLKA.s-.s+RQ........................-MAshluQKpL....RslILsplI+................	0	26	35	68
+11675	PF11842	DUF3362		Domain of unknown function (DUF3362)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2839 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 117 to 158 amino acids in length.	27.60	27.60	29.10	28.30	27.20	26.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.01	0.71	-4.30	9	1200	2009-06-18 12:37:54	2009-06-18 13:37:54	3	3	1181	0	232	851	107	136.70	46	19.49	CHANGED	DQVQsFYPSPMATATAMYHSsKNPL+KVsRc.....sEsVDIV+GEKpRRLHKAFLRYHDPsNWPlLR-ALKpMGRADLIGsGKpHLIPsaQPh.sDG......uYQSAR+KNSo.......................................ssG..shps...........spspKG+hLTQHTGLPPRsss	.DQVQsFYPSPhAsSToMYYTGpNPLt+lt.a.c......oE.cVhV.PKG-+QR.RLHKALLRYHDPsNWPLlRpALctMG+c.cL....IGsp+cCLV...Ps..........ss....hc.......................ph.pp...u..R..+..p.spp...........................s.t.st...h.ttt.................................................................st.sttttttt...........................................................................	0	66	143	189
+11676	PF11843	DUF3363		Protein of unknown function (DUF3363)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2310 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 323 to 658 amino acids in length.	28.40	28.40	42.40	30.30	25.60	24.80	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.27	0.70	-5.82	40	413	2009-09-14 15:03:38	2009-06-18 13:59:04	3	5	192	0	169	399	41	221.20	32	58.09	CHANGED	LhlGRLp+LEchGLApphuPGpWplpscsEssLRcLGERGDIIKpMHRAh.stcGh-..Rssusaslcspt.s..sPllGRLlsRGLc.DELpspuYsVVDGlDGRsHHlclsch-ssucsss.GuIVElRsh.s.......................................................................................Dsptppp..lslssRSDLsLppQlsAsGATWLDRphluc-s.sLut..uGFGtEVRpAhcpRs-+LhspGLAcR.pupRllasRsLlsTLRcRELsssupcLuucTGLsaptussG-pVuGsYRp+lsLASGR.FAMI.....D.....cGLG.FpLVPWpPsLE+pLG+cVoGls+ssGGl-WshGRcR.GLGl	......................................................................................................................................................................................................................................................................................................................................................................t...h.lthho.hslttQht..usTWLDpphlttt....shs......GF....Gt..psp..tAhttR.thh.tpt.App...ptttl....hhttshlthLctpEltthutphu.t.u..h..sttGp.ltGhhptph.LuSG+.aAhl.....-.....puht.FpLVPWps.l-pplGppl.uhhp.ssulsWph..uRt+.u..............................................................................................................	0	24	107	141
+11677	PF11844	DUF3364		Domain of unknown function (DUF3364)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2336 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 60 amino acids in length.	27.40	27.40	27.40	27.40	27.10	27.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.77	0.72	-3.94	40	333	2009-06-18 13:02:42	2009-06-18 14:02:42	3	3	292	45	92	315	8	54.70	45	14.47	CHANGED	MsQss-.......+lhDHhsLF+cPEYp-hhpsKpcpFEssh.ssccVscltEWTKTWEYREKN	............MsQ.osE.......+lLDHspLF+-sEYpchFpsK.ppFEsst...sspcVpclhEWT+ohEYREKN.	0	24	57	72
+11678	PF11845	DUF3365		Protein of unknown function (DUF3365)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2563 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 198 to 657 amino acids in length.	27.80	27.80	27.80	28.00	27.50	27.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.67	0.71	-4.44	153	684	2009-06-18 13:07:17	2009-06-18 14:07:17	3	87	394	0	307	670	98	181.10	17	39.40	CHANGED	lhhshlh........hhhhhhhhh.........................h...p..pts..tppshpp.Acshhpph...............shRp..........asspphtsh..h...................................shthshhs...........P.uhhsppl...tc.......thsp.tt.s..hhph+hsoh..pspNPp.NpsDs.aEppsLcpFcpss............tphhph....su..pphh+hhp..P..lhh.pps..CLpCHu......t................t.thsaclG-lpGuhslsl.Ph	.............................................................................................hhh......h....h.hhh...h....................p.....t.h.....t..hh..pp..uphhhpth...............t.h+p..........ahsphht.h..h........................................................................s..hth.s....s.shhshpl...tp........hsppt.s.......hph+hsuh...ps...pNsp..stsc.....s..aE.pchlcpFppst.................t........ph.p.....ss...pshhRhhpP..lhh..pps..CLpCHu....t.t.......................t.saphG-ltGshslphs.....................	0	130	249	287
+11679	PF11846	DUF3366		Domain of unknown function (DUF3366)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2678 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 200 amino acids in length.	27.90	27.90	27.90	30.10	27.70	26.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.36	0.71	-4.43	29	415	2009-06-18 13:09:44	2009-06-18 14:09:44	3	5	380	0	90	371	29	192.40	21	34.03	CHANGED	lhhhullhslslHShLEYPhaYuhFhlshhh.hLhhh.s......sth+...hshphs......hsLt...shsllsshhhshhhhp..shppsphL.ha.....tspsss.....hppsssshhatp..sas.hsshh.hsh.p.tssshhhshhphuhclh...P.....psshhpph..hhuhshhGcpscA..............pphhppsphlas......................hppapsh...hpphstssss	........hhhhulhss..lhlHuhLEYPhaashhhh.hhl.lLhhhss............pth+..........hhs.hsth..................hhLh...s.shhlhsl.lshhhhhp....sh...p...p...s.phL.st..ap....tspshs.ph.....hppsp...shlh.t.pp..tashaushh.l.sh..tpppsphhps.hhchuhphlp.pP.....psshhpph..hlhhth.GcpscA............................cphhpphphlaP..........................................pth........................................................................................	0	15	42	65
+11680	PF11847	DUF3367		Domain of unknown function (DUF3367)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2726 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	26.00	26.00	26.00	33.70	25.90	25.40	hmmbuild  -o /dev/null HMM SEED	680	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.20	0.70	-13.27	0.70	-6.58	14	220	2009-09-11 09:45:00	2009-06-18 14:11:38	3	6	191	0	63	201	18	617.40	44	51.49	CHANGED	llhhhlsFtQsPGplusDTKlDLslNPhtFLsRAhahWssshshGQlQNQAYGYLFPpGsFFhlschLtlPsWVsQRLWWulLLsluFhGsltLscsL......slGuss.sRVlAAlAaALSPRlLTsLGulSuEshPhhLsPWVLLPlltsh+.....................................ssRRhsA....hSuLAlshhGuVNAsATlsullsAsLalh..stt..pRhhph.huh.Wh.....hulhlAohWWllPLLlLG+YuPsFhsaIEouusTTshhohsElLRGsssWssals....sthsAG.tpLVssshhlhsTshVAulGLhGLshhthPtRthhsshLhsGlslluuuahst.suPhup.VpsaLDG..sGssLRNlHKh-sllRLPLslGLApLL.stl........slsh.ushtth...hhp.th...........t+hAsslhslhllssusuPAaoGclhss..GsapcVPsYWp-AA-WLssc...ssu.o........RsLllPGusFup.sWGpo.hDEPhQsLh-sPWuVRDulPLssPtsIRhLDul-ctLpsGtsssGLussLtRt.GluhVllRsDLsscsstsshsh.hh+pslt..coPGlspsts.FGsshtsssh........hlsDsshcs..hh.ul-lap....Vsss..........sssss..hthssscshhhVsGusEuLhpLsusshhtst.....................usslhsu-.t.ppss...ssss....ssoDsstspcssaGp.....sssssushhsss..................-....spsshshlss	................................sshhlsFsQsPG.lusDTKhDLssNPhpFLucAhphWssphshGQhQNQAYGYLFPp...GsFFhluchLt...l.PsWlsQRLWWulLLsluFhGhlRlA.ctL........ulGusu.oRlluAsuaALSPRlLTT.LGuISSEshPhhLAPWVLL.Phlhsht...t............................................sstthAAtuulAVAhMGAVNAsATlAuslsAslahh....................s+t...........s.Rh....hhRh...huh...Wh......huhsluohWWlhsLhhLuthSPPFLDaIE..S...usVTTpWhSLsElLRGTsSWTPFVs.....sptsAG.tsLVTsshhl..luTshlAA...hGLsG.L...s...h.t............hPtRt...hhlhhLhlG.lllhss.uahut...suPhut.lpsaLDu..sGssLRNlHKhsPllRLPLsLGlAphL.u+l...................sl.stssst.t....hhpspps............................+plAssllslhslhsuso.AWoG+lhPs..GsastlPpYWpcAA-WLspc..ssss.................RsLVlPuAsFApQsWGho.+DEPLQsLhs.s...PWuVRDulPLsPPtsIRuLDuVpphhssGtsss.....GLus.sLtRt.GluhVllRsDLDscsspostsh...lh+pslt..tsPGlt+l.spFGsshssssl.ts......hl.-sshcs...thsAl-lap...Vsss...............sssus...shhssscthshVsGuP...EslhpL..sp..p..tth...u............................uPslhsuD.u...ptsuh.....ssst.....sloDsshsR-s-aGp......lsspsSshhuss......D....hptshsh.........................................................................................................	0	14	44	58
+11681	PF11848	DUF3368		Domain of unknown function (DUF3368)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2745 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is about 50 amino acids in length.	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.93	0.72	-4.40	50	241	2009-09-14 14:59:35	2009-06-18 14:13:08	3	2	142	0	94	302	28	47.90	28	32.24	CHANGED	plpGTLGlLltAKpcGlIs..pl+sl..l-pL.ppsGaalupplhpplLppss	....lhGTlGlLltAKppGlIs..pl+sh..lcpL.ppsG.ahlupplhpplLphh...............	0	32	74	88
+11682	PF11849	DUF3369		Domain of unknown function (DUF3369)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2927 (release 23.0)	Domain	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 170 amino acids in length. The domain appears to be related to the GAF domain.	25.00	25.00	25.10	26.00	24.40	23.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.79	0.71	-4.32	63	346	2012-10-02 14:34:25	2009-06-18 14:16:17	3	20	234	0	123	289	44	170.90	27	29.85	CHANGED	lhouLRSYcsIpsI-psRp.......GLE+llcAousLh..phcolppFusGlLsQlusLLsls.ssulhs.................sspss..........tpp......tt...hpllAuoGp.asshhsps......htt....hsspltphlppulpp.+psla.pcsthlhYhssp..s.spphllalcst.psLs-h-ppLl-lFspNlulua-NltLhpclccs	............lhouLRoYcplptI-ps+p.......GLp+llcASuslh..p.t+olppausuVLsQlsuLLslp..ssulhs............hshpss....................spp.....tt..hplluusGp.apt.hhsps........htt....lstcl...tptlcpslsp.....+pshh..tssthlhahpsp..p...uhps..llYl...pst...p..pLs-..h.-.cpLl-lFstNluluF-NltLhpcLcc.............................................	0	38	66	86
+11683	PF11850	DUF3370		Protein of unknown function (DUF3370)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3037 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 452 to 532 amino acids in length.	25.00	25.00	67.30	67.30	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.38	0.70	-6.02	31	109	2009-06-18 13:19:48	2009-06-18 14:19:48	3	3	55	0	43	130	73	441.60	43	92.32	CHANGED	shhlsss.......................shhtsstssssthss....p........QclRPLPGpLssVPVlNSNsPElVpu-GILlSTFPs......ttptpPtspL......sasFsGRFDlFuHHlatspsspch.....cs.LaLullstNPuspPVTlplhpGuopLS......ps-APFlsLPshhscshG..slhuGPGsRsus-lL.RGcpstcLPsp.lsIPPtptphLlsLPIPlpGls.......................................NGRshhlRhcSsGPlhhAslAthu........................psPo.pcWhslLpsGpLu.sR-ahPoPh.....thpsthIYSRVAGVuhGopWpAploD...ttt.L..shsstslSaPloSLp+GphGTsQlQoA.LhsRhPDTAasAHGNYGVcYDLsLPLpNsusp..slpLsLpoPlKssc....tttLhF.t..ps.shFRGolclcht-sttt.....+hlHLs.RpGQ.G.sLsplsLpPGcp+pVcVsLlYPADATPPQVLoVhPlp	.........................hhhhhhh...........s...hssp.ls...psQplRPLPGpLDslPVFNSNSPElVpsEGILLSTFPs......pscthPsAHL......NashpGRFDlFuHHlspspsspch.....co.LYlGllstNPu.spPVTlclLpGuSaLS......psDAPFlsLPshsc.sspG..sVauGPGSRlssDlL.RG.......pppsphPsp.llIPPspschLlshPIPlpsls.................................................NGRSshhRLp..Ss..G......s.......lYhAsLAhau................................p..sst+sPoLp-WpsLLppGpLu.PRDhhPTP......tsssphIYuRVAGVuhGSpWpAplsD.s.ttp..hLt..lPtsGpuhSYPlSolptGshGTsQlQoAshhsRYPDTAYpAHGNYGVcYsLoLPLhNsospspoVslsLpTPlKpsp....pstLhFhpsssstlFFRGoVclpYpDcput.pp..RahHLVQRpGQ.GpsLlplslpPGcpR.VpVchlYPPDATPPQVLTVpT..p.....	0	2	25	39
+11684	PF11851	DUF3371		Domain of unknown function (DUF3371)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3115 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.	25.00	25.00	26.60	26.70	23.30	24.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-11.07	0.71	-3.46	20	373	2009-06-18 13:21:43	2009-06-18 14:21:43	3	4	107	0	112	312	0	132.00	43	32.44	CHANGED	hQARAHGL.sshsSsuls...os-Lss+l..lKQpssh-c.............................................ssp....c......lhs.p.tppPphssss.............sLDls...........................-GshsFsDsLss.sspshshu..hptpp.cL--lLMDD..........sLSPl..uoDPLLSosSPs..uSKsSSRRSShShEEs-	......................................................................................................................hQARAHGL.shhs.SsGls......os-Lss+l..lKQEsslEp...............................................sspp.................hh...p....ts...shssss...........................sLDLs.................................-.Gshs..Fs.ssLu.stss....s...s.hshu...p.tp.cL--.lLhDD...............oLSPl..soDPLLSohS....Ps..ASK.s..S.SRR...S.Sh.ShEEs....................	0	4	14	44
+11685	PF11852	DUF3372		Domain of unknown function (DUF3372)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3259 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This presumed domain is about 170 amino acids in length.	29.70	29.70	30.50	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.88	0.71	-5.11	37	294	2009-09-14 08:08:02	2009-06-18 14:23:36	3	29	264	8	103	277	30	163.90	36	13.66	CHANGED	ohpsNN.WsVGLPhtp+stssWshIpsll..sssshcPsts-IttspphFpElLpIRpSSsLFRLsous-I.pRVsF+NsGssQhsGLIVMSI-D.G.sts...........tslDsph-ulVVlhNuosppho.hsls....shs.u...apLHslQtsus..Dshltpu.sasss......pGpFTVPAhTsAVFVpsp	......................t.hpsNNaslGLP.tscst...ssWslhcsll..sss..shcPsss-Ittssshap-LLplRpSSsLFpLsouscl.pRVsF+...NoG........s.s.p.hP.GlIVMoI.....-D..u.tts...........sslDsthsulVVVhNAospsho.hsh.........shs..u.....apLHslQs..suu....Dsslp.tu..shssu......sGphTVPAhosAVFsp......................................	0	29	62	92
+11686	PF11853	DUF3373		Protein of unknown function (DUF3373)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3442 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 472 to 574 amino acids in length.	28.00	28.00	28.50	40.80	27.70	27.90	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.81	0.70	-5.96	18	144	2009-06-18 13:25:15	2009-06-18 14:25:15	3	2	135	0	39	127	11	496.60	45	99.04	CHANGED	MKphhphhlsush....hshohshtutss-hsh.p.cl-pLppclppLcpQht.................thppplpchEc..............+ohuchLphuGDaRa+lDulch+..s.....................................................h.th...s.....................................................ssutcscN-slaTNRhtLsh+AKsocclohpuRLsMYKsaG.....t.ssssspsaauspsh.hhDGshscsPo.sshLpV-cAYhsWpN....IuDpP.hahSlGRRPSTsGsPupLRpNpp+sus..sPuhLlcasFDGhTlGas....s-.lsulsG.sasKlCYGRGF-su........assst......NshcDTDhhGhsllPhDssshplphpa......s+uaN..lhshPs.hss.F.................stsssssplGsl.sahGhuhh.phcslGsG......shshFsShuhSpTpPsss.........h.hssh.....puhLsus..............ss+TGausYlGscash...ssssKhGhEYN+GSKaWhoFs.PAtDDhhsSKluTRGssaEsYhIpEL........hs+hFh+LuapYYDa-YTGSNsalGA....PhKIs-lpus.h...hhs.......................................slcpApDlhuohcl+F	..........................................................MKThhSLlLuAsL....LooSLhAc.ss-DElspLQpQLAplpuELApI+cEp-spscpsp...............................ssptclADLNDR.s.DcTEh..............pAALs+lKFGl-FpTuVsNhsYK.......................................................................................................................................................................................VsGQDhssN..shahNcL+LNMsAclNDcscFaGRLSMsKNWu............QhGaSussh..sLDuspNspo.S.GssLhVDRAYhDYh.....Issp.WhsolGRpPuTDG..PsSNLRsNuLRpST..hPA.LsINshhDuAslsYc....PEsL.p...-ac......sslRhsYG+saphspt...............hhcWhusppsuD......sNlhhsss.....GtLsI-uhsDshlhh..slsa......hssFs.......l.shsshh..ss.h............................hpsssssNLGDl.sluslpFp.shc..uhGs.......NFNaFsSLGaSpusssph...............sshh......puh.Lpsp............t.s-cDGYAVaVGuRYDh.....ocuhKlGaEa.aGS+YWhTMo.PuhsDPlsh+h.TRGsAa-hYlIapL........-chtFlRLSYTpIp..auspGhPF.Gu.....sKh...DcucAssh......MhMh.......................................sVK........................................	0	14	32	36
+11687	PF11854	DUF3374		Protein of unknown function (DUF3374)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3548 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 665 to 712 amino acids in length.	20.70	20.70	20.70	20.80	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	637	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-12.94	0.70	-6.27	30	127	2012-10-03 17:14:37	2009-06-18 14:29:26	3	2	73	0	59	117	34	615.40	28	90.44	CHANGED	Gas-sDDh+..tuNsa.......Gs.psGhsutlsADlpapscs...GYpsplpAcpLGh-suphplpsG+.GpYplsL.sYcpls................pYpsssshos..............a..............WhssG..........hsthpssl....ssh-LslcRc........+hulGhp....Yps........shapsalp....Yp+EcKpGp+...p.......uShshh.s.ps...................s......lucPlD.toTcplsAGlphpG-s.....WhsslsYpGShacNchssLs.....hssshssh...............................s..AhsPDNpAHplulsGQYphs.pophsGRlshGpMoQDpshlshs......................ssPh..pshDGpVDTlshslphoo+lspcL+LsuuaDYsDRDN+oss.hpasQhph..........ssls.Gtst.....NsshDpp+pphclsusYRls+sh+LpuGY-acps-Rott-............REpTsEsslau+hph+shsshshtlKuuausRsGScYpss.phou........upsNsLLRKYY...L.ADRcRsplchcssa.....ssh-sLolshsscYupDDYsc.Tp.lGLTEucDhGYDlsluatls-clslpAFhspQaI-.......SsQu..GSsshusss..........W...puslcDchsslGsGhsYs...sLh-s+LsLGhDYoaSsSpScTpl.............spshsssYGDYaupsHs....lphaupYplo-phu..........L+LsYpaE+YpDsDaup..lss......suIs.....slhohGslsHsYsAHhlhLohSYpL	..............................................................................................................................................a.st-s.p..tsNth.......us...psthhutlsuDlp...h...pspp.......GYpsplpAppLGh-sshhplpsG+.Gpaplpl.sYppls................pap....sssshos..............a....tt.......h..........hhss..u..........t.....................hshh.ssl.............ssh-LulpR-........+hslGhp...aps........tshapshls....Yp+Ec+sGt+......p...........sShshh....s..ps...................h..........lscPlD.toTcplpAGlphtGcp.....W.sslsYp.s..Sha+N.chs..s.Ls.....apsshsss...............................h................st.uhsPDNpuHplu...lpuph...shs...psphsu+lhhupMoQD....pshlshsh.........................thPs.....pshDGcV-hhths...lphsu+lop..slplsuuac...YpDRDNposh..tasp.h.h................................................sshs.Gtst......NssaDhp.ppphc..lsusYRlspshpLpuGYcacps-Rsht-................................Rc..pTcEsslau+hphpshsshshhlKspaupRcGSpYpss..thop.........................upssshLRKa....L.ADRcRpplchcssa........................sshpsLolshssphs.DDYsc..ot.....l.GLocscsh.u.YDlshsa.lssslphpAahspphh-.............ScQu...Gussh.usss............................................................W....hsphc.D.cs..sslGhGhsap...sL..h-s+LplGhDY....oYSsup.SsTpl......................ttuhsssYsDhhup.Hs......lphaupYphs-phu..........l+lsapaEcYp-sDatpp.hs.......ssls......sllshGs.hspsYsAphlhlohsYph..................................	0	9	23	38
+11688	PF11855	DUF3375		Protein of unknown function (DUF3375)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3589 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	25.00	25.00	26.50	30.10	23.60	22.90	hmmbuild  -o /dev/null HMM SEED	478	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.43	0.70	-5.75	28	246	2009-06-18 13:31:11	2009-06-18 14:31:11	3	2	231	0	95	249	38	458.70	24	95.80	CHANGED	lptlR..pcpPAWRLLtuppAPllluhLcphFh.ssspslPps-LtptLccpLtsLccpttp.........tthPps....ApsYLs-Wst..p...GWL++hhsp.sss.-spa-LTsssccAlpalssLpppp..hsuTESRLtolhptLcpluptspsDPctRltpLccc+sclctEIsclcuG.clshhDssplt-RhpplhphucpLhuDFRcVccsa+pls+plRcclhs.pus+G-lLcplhsphDs.ltsS-pG+SFcuFachLhssspppclsphlcplhsh...stpLcsctR..Lpplhtchhctu-cVpRshp+hucpLR+alcspshhEsR+lhplLpphpstAhsh.....pct...sthhhshsthusshphshpp.hhpsPs.......psthsshsh.sssssch...shsshhststlDhpclttt.....lppsLt.pps...pholucllpphP.hppG..LuclluaLplAt.........ptsh......................lscppppplpapst..sGh....hRpsplPplhhsc	...........hR..pcpssh+LLtuppuPhlluhLpphF..stpttlspscLhppLpcpLttLpppttt............t.hsps.......ApshlpcWsp..p...G...WLp+hhst..sss..c.........hacLTstucpAlcalpsL...p.ppp..hsuTtSRlpslhptLcplutpsssDPppRlttLccchpclctEIpclct....G..p..h....shl-spphh-chpplhphucpLhsDF+cVppshcpls+plRcclhs.....sct....spG-lLcplhsth-t.ltcS-pGRoFpuFaphLhssppppplsptlcplhph..hht.tLssp.Rt.l+plhtclhctuppVpcshpphucpl+palpspshhcpRplhplLpph.stAhsl.....ttt........t.thhh.ht.ths.ssh.h..s.ltp...hhpsss.......pst.h.s.sh.h..tsssssl.s...shsslhspstlDhtpLtpt.......lpphlt..pps........lolupslpphP..pps..LuclluaLslut....ptsh.................................sspsp.tphlpaps......-Gp.........RphplPtlhh...................................................	0	24	63	86
+11689	PF11856	DUF3376		Protein of unknown function (DUF3376)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3667 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 770 to 1142 amino acids in length.	25.00	25.00	25.90	25.90	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.73	0.70	-5.13	23	113	2009-06-18 13:33:06	2009-06-18 14:33:06	3	3	102	0	35	96	6	449.00	32	49.25	CHANGED	hsslhuuluslPRppsh+spLttlpt.spphp+hcplhsuhRschppthpp...........thu...shhtsp.pstcLpthcscstptt.....shttshsatshhpsclst...hlctlspllsths.ttsssp.tttthpshhtph.t.........thsslsshps.sstsshtthhpttc.....hsh+hRRLphlsccLs.................csh......csssstc..........ssslsttcpslhshl.t.ulhpstcthtt...............hucshpc.lsssshsh...........ss......plhchlsphth..............t..pshtthctpu..-phLus.hltthsp........sh+tpl....LhsYL.u....asaaDlsshPhh..tstsh..sphp.lplsRISP-DAso..lpsssst........spLtGhphssFGAFhsRuaRcNDalWGRLcGA-Rllcllhsstc......................................................................................................stls......-hshhs......................lc+..ptFhslLcEEhspLh...........................................................................................................phs..............shlusLcsp.....ss	.....................................................hpsIhup.ssh.tcpss+.cLtplttp.c....pthphlssuhhschcpp.sp...........t.u...slh.shhphhphss.cstssppu......h.tuauhphhst.schst............lscp.hshhh.hhsh.....ttsssp.shsp...stltph................stsshshs....pu..sshsshtshhphtc......shclttLt.lsctlp............................psh......css.ssts............sslst.hhssh.shht..sl.phtcthtt...........................................usshpp.lssshhss............s......sltphhsshss....................................................t.sL..hthcths..st.Ltp.hlshLss........p.t.ph.......hhthh.s....hsh.hphshhPh.....tt.c.......slclsplSs-stsh..Lssshps........pKLsGhpLtpFGAFapRuWRtNDahWGRLDGAshLVclLLsspc......................ht.................hhtthspptt....t.ttphhhs.hpp.tt...h.t.t.................................hhs......-hshhs....................st..ltt...th..plht-Ehstlh................................................................................................................................................p.............................lupssstst.hht.h.........................................................................................	0	13	30	34
+11690	PF11857	DUF3377		Domain of unknown function (DUF3377)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3829 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 70 amino acids in length.	25.50	25.50	26.00	29.40	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.53	0.72	-4.35	20	249	2009-09-11 16:26:36	2009-06-18 14:39:46	3	11	47	0	110	190	0	73.20	44	12.91	CHANGED	sssscccccthspDs..s-lllcl..D....-s.suossAlAVVIPhlLsLClLsLlYsllp.F++KGTPR.................+lLYCKRSlQ-WV	..................s...ttc.-tttspDc.....scIllcl..D....-s...uuoVsAlAVVl.P.slLhLClLsLlYslhQ.F+RKGsP+.................plLYCKRSlQEWV.	0	4	15	44
+11691	PF11858	DUF3378		Domain of unknown function (DUF3378)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3989 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 80 amino acids in length.	27.00	27.00	27.00	27.70	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.64	0.72	-3.92	33	937	2009-06-18 13:41:57	2009-06-18 14:41:57	3	2	910	4	78	516	5	78.90	34	26.11	CHANGED	sshVl.pssppplpphpppYtshhssphsssshFtAKhsssoIosYpSGKVlFQGpsAEp.Au+a.th.spppttsssssspsh	.........................sIll.phopcsIpshhppY.ps..h.s.s.sts.shhpahuKhsssTlolY.pSGKVhFQGp...pAEthAspa..th.st.ppptt.t.....s.....................	0	18	35	60
+11692	PF11859	DUF3379		Protein of unknown function (DUF3379)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2469 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 234 to 251 amino acids in length.	26.50	26.50	26.80	29.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.45	0.70	-5.19	25	166	2009-09-14 14:58:51	2009-06-18 14:53:41	3	2	162	0	38	115	10	236.60	48	98.12	CHANGED	MDELEFRR+hhuDPpspDs-hLpthppsspcppFls-lppLDt+lppALc.VDVPDDLADKlLLpQ.....phppcp..........spR+p.s+h.tlAlAAS...VAFssGlhh..u.lphus...............ssLu-pALuHVaHE.s.hshphDcslshppVNAKLushusphstcF...PG+VaYssaCcFpG.s+uLHLVhQGcpG.KVTLFIVPlcschsh.t..sFsDsphpGhshtsssAshlLVGEpupDLshlpcclppshh	............................................MDELEFRR+lhSDPKp+Ds-hLshhsuS-uNsKFlDDlLpLDppIspAhK.VDVPDDLADKILF+Q....lc-.c+.................llRPpFsR+.AMAlAAS...VAFsAGLll..GQlpWGNhhl........sPApASLu-hAlpHVhHEcs..FVpcl.DEpsshpQINAKMtPFuhphpucF...PYHVYYLNHCGFGc.sNAlHMVFQGE+G.KVTLFlsPIcStpss......tFppcGMsG...llpPl.usASlILVGEcsEsLsslAp+Lhshlp................................	0	6	14	26
+11693	PF11860	DUF3380		Protein of unknown function (DUF3380)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2757 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 194 to 284 amino acids in length. This protein is found associated with Pfam:PF01471.	41.90	41.90	41.90	42.20	39.00	40.60	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.24	0.71	-4.23	35	230	2009-06-18 13:56:43	2009-06-18 14:56:43	3	11	203	0	58	211	23	167.30	36	58.52	CHANGED	lphAslhAVscVESsGt.GFh...s....ss+PtILFEtHlFaRpLtt...........t..stphssphssls...s........p.tGtYts................usuca..............pRLcpAtulsp.....cuAhpSsSWGhaQlMGa.paptlGY.sSVpshscsMpt.uEspQLcuhl+Flct....ss.LhcsL+s+c......WssFA+tYNGPuatcN..pYDtKLspAYp+as	............................................................-.AslhAlscVESsGp.uah........sstcPtILFEtHhFhRplss............................................thhs.pts..sls...ss................p.tGtats..................tstca...............+LppAhslst.....cuAlcSsSWGhhQlMGh.pa....phhG.Y.sSVpshVsthpp.u-stQlchhl+FIct...............st.LhpAL+..s+c......WssFA+tYNGPuascN..pYDt+l..scAap+a.................	0	12	32	44
+11694	PF11861	DUF3381		Domain of unknown function (DUF3381)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2792 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 156 to 174 amino acids in length. This domain is found associated with Pfam:PF07780, Pfam:PF01728.	25.00	25.00	34.50	33.80	22.80	23.20	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.10	0.71	-4.73	39	321	2009-06-18 14:02:02	2009-06-18 15:02:02	3	10	278	0	238	322	5	161.80	31	20.48	CHANGED	lhps....c+K++pRpGY--GDhhl.a+phslh-Fl+s-..cPl...shLuphNclsh............cD.thchlpchcpTTsElhpChcDLKVLG+K-F+tLL+WRpplRchluhspt................ppcpt.......phElcthsEEppl-..cElp...p..hhE+pptct+.+c++cpscpKp.....K-ll+.Qhphh	......................ppKKpKt-GY-EG.D.hsl..a+phsss-Flpss..sPl...shLup.hsclsh.....................................................sD..t....ptlpcp.tTTcEI+tCCcDLKVLG+K-h.+t..LL+WRhcl.Rchhuhphcpptt................pttpp................................tt-s.pshc--t.plp......c-lp.......p....hhccp..t...tc.hK..+..cc++..c.pc+Kp.....Kchh+.php.................................................................................................	0	84	133	200
+11695	PF11862	DUF3382		Domain of unknown function (DUF3382)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2882 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 100 amino acids in length. This domain is found associated with Pfam:PF02653.	28.90	28.90	29.40	29.40	28.70	28.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.22	0.72	-4.10	45	897	2009-06-18 14:04:04	2009-06-18 15:04:04	3	5	808	0	148	478	130	101.60	41	23.71	CHANGED	hspsL+pAlhuAllshllhssllGlpLp.t.GspLslp..sp.s.hhhhVuhuslshFlhpLa......+shls.tshsssp..hsslss......shsptpRhllhsLllhAlla	.......................h...plt.ALhSAshhhlLAulhhGlQL-...LDGT+LVV-sAuslpWpaVhIusAlVFhFQLl......RPhhp..+ulKsVS..us+alLPu........h-Guos.+QKlalhALLVlAVsW..............................................	0	18	50	96
+11696	PF11863	DUF3383		Protein of unknown function (DUF3383)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3017 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 356 to 501 amino acids in length.	27.00	27.00	27.20	27.00	25.80	26.90	hmmbuild  -o /dev/null HMM SEED	481	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.33	0.70	-5.82	26	463	2009-06-18 14:05:44	2009-06-18 15:05:44	3	3	282	0	49	410	14	282.30	18	97.36	CHANGED	slsclVsVslslsstuusst.shsshLlhs......psshssspphpsaoohpsVus.sFGssoscYpsAthaFuQ.....sspPsplhluRasp......s..s.l.u..ht......s.hpth.sGshplshsu...h..stlshst.hshsssAt.hpstht...........ss.hs..tttahltssssGs.....................................................................................................................hs.s.sss.huthlthpss.t....sh.s.uhss-ohspAlsshts.hsssWashthust..hsssphlAlAsahp.....ttshp+lashsspcssslsss....ssslhttlhs.sshppohshYsss........ssY.sssuhhuthhossasuspstlohta+p..sGlsu......-.slssopusALcspssNhasph......ssshuhhpcGhhsuG....pahDphtshsWLpstlpsslhslLhss..sKlPhs-sGhshLhusl.psshspulsNGhlusGh..........stshGshssGchlt.tGYalhs.ss.hsp.upssRpsRptsshphshphuGAIHpl-ltssls	...............................................................................................t....hh............................h..h....t.h...............h.hs..hh.............h.h...........................................................................................................................................................................................................................................................................................h.t..t......tah.h.........h.................tth..huth.t..............t.thh...hh..st..t...........................t....h..h.............t........hhuhh.h.sh..tt.................s..hhhpt...ul.........t....h....s.sthtth.............t...t..h.hh..........tth....httGhh.ss.....ahD.hh...ah.t.hp.th.th...h.p.....tpls.sttG.shl..s.h...ttshtthht.Ghh....................................s...a.h.........t.s.t.httR....h.h.h..usulp.h.h...........................................	0	9	28	40
+11697	PF11864	DUF3384		Domain of unknown function (DUF3384)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3114 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with Pfam:PF02145.	28.10	28.10	28.50	29.10	27.30	26.70	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.63	0.70	-6.02	26	254	2009-06-18 14:07:29	2009-06-18 15:07:29	3	12	181	0	161	269	0	408.70	28	26.91	CHANGED	pps.lspRhcthcplscu.lppa....sh....ssl.tlWpsup...DLlpsppsscs.R+suhpLLptslpppct...............................ssstRthaFcsI...........sss.sps-s..ls.......hpLpuLpsLT.....ccG+cl..sa.hppslhshlspal.shh...............t.h..t+...tpt.........ts.s....-sshlsslLphls...sll+astphhsppplttllpplhpl.CppToss.............................................................................................................................................s-l....pssLplhDulIp..YuslPspohsshlplLC...................................................................................................................................................................................................................................................................................................oh.hshs..............slspssh+.....slcNLhco+htpphlpsLpshL.......tssppp....hp........shslLR.........................GAltllphllhss...tppthst...............lphs.......lhsuhhsslc....pssstlsh-llphhpsll......tphsph.hhppsWs....hhslhsp...................................hhsphtshttstss.tp............................pplhsphpplhsp.lEpLhcp..hphp.p+c.chhpFlhpstphlssussphllthhpspphssPsss......tWlpshppllcpFh.spspssslRlpslpslpcs	.......................................................p..s.lspRhchhtplsch.hpph....ph....psl.t..lWpssp...DLl.ps.pp..s.s...-s.RpushpLLpsllptQs.p...............................hs.hhR....thaFpsI.............ps...sss-D..lp...................pLcshpsLT.....-pG+cl..sh.h-pclh.h..lhpWh.............................................................................................................................sh.sphl.hll...sllKFNtshhc.phlsth.lp..lhhl.ChpTsss.............................................................................................................................................sDl....css...LpllDAlls..YsslP.scsLs.hl....sLC..........................................................ph.hsht......................................plsps.sW+.....hh+NLht.o+hG..pssl.hshpplh...........................psps.........hc.................sssllR.........................GAVhhlth.hLhus........cth.s......................lp.s.......llsuhhp.Ahp....ssst.h.Vsh.Ell.hslppLl......tchtpp.ltth.sWs...hll.slhpp.....................................lhpplpsh.pt.p........................................................lp.s.lpcllss.lEpLhpp..sphp.sspcchhpllpps.tcphP-ushh.ll.....hctpphpPscs.tWlpsl...phlhcpFa.pppp...psslRlpsLpsl...s................................................................................	0	46	76	129
+11698	PF11865	DUF3385		Domain of unknown function (DUF3385)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3188 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is typically between 160 to 172 amino acids in length.  This domain is found associated with Pfam:PF00454, Pfam:PF02260, Pfam:PF02985, Pfam:PF02259 and Pfam:PF08771.	27.60	27.60	27.60	30.90	27.50	26.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.31	32	388	2012-10-11 20:01:02	2009-06-18 15:09:47	3	34	278	0	259	390	7	159.30	37	7.12	CHANGED	VlpPYhcYPpLLslLhslL+sE.pp.hslRpEsl+llGlLGALDPa+a+....plppstp........s......tppss.ssshhLhh.uhts......ss--aassVsl.psLhp..ILpDsSLspa+s.sllpuI.......hpIF..ps.hulcC.lsaLspllPshlpslR.ssss.shhEh.happLupLlslV+	............................VlpPYhcYPpLLslLlshLKoE..ps..tslR+Esl+lLGlLGALDPYKa+........lpppts.......................................................stp..t..tspss..s.ss..hL...l...u.h.s.....................st-EaYPsV..sI.ssLhc..IL+DsSLupaHs.tV...lpAI.......hhIF...+o.LGl+...C..VsaLspllPshlsVlR....ssss.....shhEh.hFpQLuhLlslV+..................................	0	97	151	223
+11699	PF11866	DUF3386		Protein of unknown function (DUF3386)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3390 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 220 amino acids in length.	25.00	25.00	30.80	30.60	24.70	21.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.15	0.70	-5.14	27	98	2009-06-18 14:28:42	2009-06-18 15:28:42	3	3	89	0	35	100	142	208.80	36	90.83	CHANGED	hssssssc-lFRsAYENRYTWDssFsGYpucshap....ps-cphpGphclu.sDLKspVpGI-Dpclt+ultuQLaEVsIHRVRRoFEpsHGcNoFsh.GcsspsG.lEl.lVuGKutGD+Y+l+sshlshVaR+IHGsllTIpThsspDTGpG.YLS+pYsS.YtDPpTG-tpuu+spFcDpat.l....ushWlLspR.sIcs.cspuppss....pp.......FpFss..........lphL	...h.hpphsAc-lFRsAYENRYTW.DtsFPGYpAclthp....pssphapGphpls..sD..hcscVp...sl-D..EclpculpsQLh-lslHRlRRsFE.psHG...cNs.Fsh..GcscpsG.lEl..lV.uGc..u.GspY+l+ssplshVpR+lcusslTIpTtssh-TGpG.YLS+pYsuhapDPpTs-h+s.....s+ppFcDpatpl....GsYalLsp.R.sIcs.pspupp.h....pp.......FtFpslphL..............	0	9	24	33
+11700	PF11867	DUF3387		Domain of unknown function (DUF3387)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3465 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 255 to 340 amino acids in length. This domain is found associated with Pfam:PF04851, Pfam:PF04313.	26.80	26.80	27.50	27.10	26.40	26.70	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.89	0.70	-5.48	52	900	2009-06-18 14:30:44	2009-06-18 15:30:44	3	11	772	0	213	818	195	283.60	26	33.78	CHANGED	osutG+GcsslDtpcAl.slhhEKh-ll+shh......+GFDYpsahsuss..pplphlssAhsalL..............u......c..........s..uK+RFhcsVhsLoKAauLsssp-E.Atsl+-EluFFpAl+utLhKhssssp..t..ssp-...hphsl+QllspAlso-t.VlDIFssuGlc+P-ISlLSD-FLt-V+phc.cKNLAlElLcKLLs--I+sRp+sNlVps+pFoEhLcpslp+YpN+uI...........soApVI-ELIphAK-hppstpRu-cLGLop-ElAFYDALAs.N-SAlc.hG--pL+pIAtELspplRpssol.DWs..tREolRA+lRlhVKRlLR+YsYPP.DhpppAscpVLcQA.Eh...lu....ppas	...................................................................................................................................................h...h.pth.ph.ht..thh.........thsh..t......h.......t............t.h...thh.......t...s.phlh.........................t..........p..hc...ppFht.shthtpuhsls...................s............p...t.......tt.......h.pp-.l.ta...httl+shl.h+h......ttst...........s.....tp............hpttl....ppllspul..h.........u.p..t....l........p.....l........h.t....h..........t............p.....l..sl..h.s............p.c.F..l.t.c....l.pphp.....pps..hthph..Lc+h..lppplp.hhcpN.sptppap-hlpphlpcYpspt..l.....................pstphlpc.Llp.h...u.p.chp.p.t.t.p.p...s...p...p.h..G..L....s..t..-.E...h..AFY....-.hLsp...s.............c..sh.....h......p...h...s..........c..........c..........p...L...p..t...l...Ac-ls..ptl....+...p...s...h..s..l...D.Wp....p+-ss+A+h.R.hhl++..l....L+...+...a...t..Y..P..P.....-h......t..ctAhptVlpQAE.ht....t................................................................................................................	0	79	150	185
+11701	PF11868	DUF3388		Protein of unknown function (DUF3388)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3650 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 261 to 275 amino acids in length. This protein is found associated with Pfam:PF01842.	25.00	25.00	39.00	38.20	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.15	0.71	-5.16	8	391	2009-06-18 14:32:00	2009-06-18 15:32:00	3	2	390	0	45	120	0	192.80	73	72.19	CHANGED	VTKhRpPKLRDRLAlRHGRYIpRDADDKKTFRFVR-ELGLLVDFMAELFK+-GHKLIGIRGMPRVGKTESIVAASVCANKRWLFlSSTLIKQTVRSQLhcDEaSc-sIFIIDGIVSsRRusE+HhQLlRElMRLPusKVVEHPDlFVcpSEYThDDFDYIIELRssssEEIpY-hsEcsphtstssF.......uuFsF	...lTKL+pPcLRDRLAVRHGRYI-pDAcDKKTFRFpR--LGLLVDFLAELFKcEGHKLIGIRGMPRVGKTESIVAuSVCApKRWLFlSSTLIKQTVRSpLIcsEYs.sN.pVaIIDGhVosRcuN.+H.pLVpElMsLPohKVVEHPDlFVcsSphTh-DFDYIIELRcs.spEIpYEchcc.p.ht.opNNh.....s..........	0	14	28	37
+11702	PF11869	DUF3389		Protein of unknown function (DUF3389)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3739 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.	25.00	25.00	28.30	48.20	21.40	17.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.39	0.72	-4.09	17	137	2009-06-18 15:30:29	2009-06-18 16:30:29	3	1	136	0	26	81	4	69.60	55	99.37	CHANGED	MllsFSpGKlIso.pElhlRLssss.VsLQApsDslpLlu.sAsVllAsGuss+WSlKLDs-pQLpslupplGlslt	.........................MVIpFStGKlIsT.+ElVlRLsttt.lTLQAps-sIpLhu.GANVhlANGSEsKWSlKLDsE-QLpsIAppLGhDl......	0	2	7	18
+11703	PF11870	DUF3390		Domain of unknown function (DUF3390)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3832 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 90 amino acids in length. This domain is found associated with Pfam:PF02589.	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.22	0.72	-4.06	34	1109	2009-06-18 15:32:31	2009-06-18 16:32:31	3	7	1031	0	194	665	49	93.20	28	19.55	CHANGED	+LRpEshpps....tp..hpupsuptsphEphsaKsauhhsosPslY+.........hhsahssch...pshhP..s.ltsWTpsRshPcPAtcoL+-lh+t+tptp	.................................................shs.ttpuhpsts..EphAhKhFuhssopPs..la+huhth.................sthhsa..h..h...ssh.........tsh..sP......u..l...psWscsR-hPpsstco..FRpWa+c+tt..p......	0	51	126	163
+11704	PF11871	DUF3391		Domain of unknown function (DUF3391)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2190 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is typically between 122 to 139 amino acids in length. This domain is found associated with Pfam:PF01966.	27.80	27.80	28.70	28.00	27.60	27.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.31	0.71	-3.93	121	695	2009-06-18 15:45:03	2009-06-18 16:45:03	3	4	415	0	262	656	53	130.20	21	32.31	CHANGED	hhh...........+IslscLplGMaVptls..sWp..scsal.h......sphhlcspppIpp.lpppGlppVhlDsp+u......s.s.......................thptssss....ph...thttpph.............t..............hshppch.......ppAp......phhscupshhpplhschptG.pslshpsspt	.......................h+lslspLp.GMalpths..sWh..c+PFh.h.......ssFhlcsppplpt....l+p.Glp.pValD..ss+u....t.shs............................................s.ttt.sts...th.......t.tspth....................................................t.sshcccl...........ppup......phhpcutshhpshhsch+.s..thshtth..........................................................................................................	0	57	149	212
+11705	PF11872	DUF3392		Protein of unknown function (DUF3392)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2322 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.	25.00	25.00	63.30	63.20	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.19	0.72	-4.07	21	196	2009-09-10 17:12:07	2009-06-18 17:11:28	3	1	195	0	46	106	9	104.90	45	96.17	CHANGED	-hllsLlsplupalpPaLs-IulAlVAClLVlaGs-IN+hL+phlushsFllRThsFlLlsAFGYGllllaloPhlspsLtplsshaLsslllssFllIGhhApRp	.....lhshLAshuphltPaLSEISlALVAChLVlhGu-INuaL++tLpshpFllRTlsFlllsAFGYGLllVhAoPaluRsLuphssthhhslllssFllIGlhApRp..	0	8	16	33
+11706	PF11873	DUF3393		Domain of unknown function (DUF3393)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2361 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is typically between 188 to 206 amino acids in length. This domain is found associated with Pfam:PF01464.	31.20	31.20	34.20	31.70	28.70	28.60	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.26	0.71	-4.81	30	814	2009-06-18 16:15:39	2009-06-18 17:15:39	3	2	791	0	95	402	21	192.00	64	53.05	CHANGED	pKhlhlhhhlhl.....LsuCo............................tp.spptsshsssh............h.+Dppu....lctLhsphu.....pplcchWGpcEhhhAu++cYVKYoDsYpoRuclsF-cGtIhlETlus..pP...pppL+pAIlpTLLhssDPstlDLaS..s.pclslsu+PFLhGQVlDpcGcsIpapWRAsRaAcYLlpN+Lps+plpptp.laaVpIsMVssHhchRut+	.........................................................................KKhLALAlIAPL.....LlSCS........................................ooKKG..ssYNEAa......................VKDTNG.........FDILMGQFA.....HNIENIWGh+EV.lI.AGPKDYVKYTDQYQTRS..HINFD-GTITIETIAG..T-P.......sAHLRcAII+TL.LMG.DDPuSVDLYS..DVcDIpI..SKEPFLYGQVlDNTGQPIRWEuRAosFADYLLpN+LKoR..os....G....L+....l....I..YSVTIsMVPNHLDKRAHK......................................................................	0	13	40	70
+11707	PF11874	DUF3394		Domain of unknown function (DUF3394)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2758 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 190 amino acids in length. This domain is found associated with Pfam:PF06808.	28.20	28.20	28.50	28.50	28.10	27.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.02	0.71	-4.74	44	269	2009-06-18 16:26:19	2009-06-18 17:26:19	3	4	259	0	78	243	664	173.50	39	20.60	CHANGED	culllhlsAslAMLlFuAATQGaFls+o+haEoslLLLlAFoLFRPGFWhDhlhPsapphsssclhphhtphssGpslRlplpG.sh..pGc.hppTlhLsls........-su.sutpRLpsh.GLpLhp..........-ssphllDtltFGSs.A-psGl-FD.a.......pIstlphs.s-RPsKEhhaIPALLLLullshhQ..RRRtpps	.....phhLshloullAMLlFoAATQGWalT+s+aWEslhLLllsFohFRPGFWhDhlhPsh..hhsuscltphspphssGpslphhVsG.sh..pG-.h.p+...TVtLPht............-tu...sup..-...Rl.....t.uh.GLt.Lh..p..........ps.s+.h.ll-hV.pFGSP.ActuGl-FDa............cItpVhhs.s-RP.KEa.halPAlLLhhllsh.Q+RRhpp.s....................	0	24	51	66
+11708	PF11875	DUF3395		Domain of unknown function (DUF3395)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2767 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 147 to 176 amino acids in length. This domain is found associated with Pfam:PF00226.	27.10	27.10	27.60	28.30	22.80	23.10	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.84	0.71	-4.58	28	266	2009-06-18 16:27:41	2009-06-18 17:27:41	3	6	206	0	180	262	3	142.70	35	24.75	CHANGED	Phpcppppcthtcp+cppcpplspc+pcAppslplhpstsp+phppEpp+sGLlIhpAhYGphss..................................................thstppshpst...........slDVTlslQshV.ccSpLhlsp.....................ssKupLhGFaDP..........................s....spcKhL+IpYpa+sphHplhlsDs-slplP	......................................Ph.ptppcpphtcp+cpttppltp.++.pEAppAlpLMpps..spRhhptE..c.p+...tGLlIlpAhYGphss................................................................................................ptptppps....................pslDVTlPLQsLV.......cc..S......p......LhLsc........................................ssKus..L.GFaDP...................................................ss...G-pKpL+.VhYpF+uhhHpVhstDp-sltlP..................................................	0	63	99	146
+11709	PF11876	DUF3396		Protein of unknown function (DUF3396)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2995 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 302 to 382 amino acids in length.	25.00	25.00	26.80	26.40	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.41	0.70	-5.21	23	202	2009-06-18 16:28:56	2009-06-18 17:28:56	3	1	102	0	71	241	2	193.20	27	58.49	CHANGED	utYpFphh..........uhpp..hp.thspc.ulsslsFolPhtalpp.s.Psh..aptLhhphAppLssppGaAGhuhsl.shshctspspEahhupRa.sGlDVssstps.....tshpls..sc.......................IKsVsWLThlssshlcpLG...GspuL+stL..s.s.hslpshss.GllIpAGsh.PphGsspcss.....hPssYlhlN+sL+slhs..pphstLphtshsupu.h..sptusptWL+RF	.....................................a.h.hh..........s.pt.....t.stp.shssLphslPhtalpp..t..ssh..atthh...hthsppLps.pGauGh...uhs...l...sts..hp......p.....t.s...h...E..ahlu.p...+a.sGLpVs.sssth.............tshphh...sp.......................I+slsWlThlupthlppLG................Ghstl+ttL...s.s.hshpsa..........ss.GllIpAGth.PphGshsts.......hP.sYhhlNphL+PlRh..pph..ttLp.h..hsuts.h...sptsottWhtRF...........................	0	8	24	48
+11710	PF11877	DUF3397		Protein of unknown function (DUF3397)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3446 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 114 to 128 amino acids in length.	25.00	25.00	26.60	26.40	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.81	0.71	-4.09	22	609	2009-06-18 16:30:47	2009-06-18 17:30:47	3	1	607	0	69	290	1	112.90	36	95.07	CHANGED	hhhhshhhllls.lhshllsth...hplp+p....th.ph...sDluh.hhhlulhhl.tphaspShlshlllhl.llulhlslhhhhpppphha++hhKhaWRhsFLlshhhYlsL....llhshhh	..............hlh.hlhllLshllshIl.sph.....FpLp+h.....th.pF....sDLAhPhLlhthalloscsascsh.L..Ph.l.hL..sl.lLuI.l.ls.h.ahhhKccs.....h...hYs+FhKhFWRhsFLLThlhYlth....llhhhh.h...........	0	18	39	50
+11711	PF11878	DUF3398		Domain of unknown function (DUF3398)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3712 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length.	28.30	28.30	28.50	28.90	28.10	28.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.29	0.72	-4.16	20	472	2009-06-18 16:32:43	2009-06-18 17:32:43	3	9	84	0	212	372	0	93.00	36	5.31	CHANGED	hp+tsplpssPLR-LlcFPsDDlplphlsRctRTlpssVPc-s.pph..sha............V+-ClcsYsp-WplVph+Y.cphSushp.hhsppphchp+.....LspQsFE	...............h.p+.splps.ssLR-Ll.FP.DDlplshlsRctRTlpsoVP--u..pch..sha.............................................................V+-..Cl+oYspDWtlVshKY..cph.Su.s.a.p..p......h.s.scphchpK.....LPppsFE.................................	0	39	55	115
+11712	PF11879	DUF3399		Domain of unknown function (DUF3399)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3857 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 100 amino acids in length.  This domain is found associated with Pfam:PF02214, Pfam:PF00520.	25.00	25.00	30.60	30.00	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.69	0.72	-3.80	11	201	2009-09-10 20:21:33	2009-06-18 17:34:18	3	7	78	0	106	192	0	103.70	45	19.28	CHANGED	LppK+NG.LsptLp.sustt-p.hhsKspShhEpQHHHLLHCLEKTT...................sH.EFlDEph.a-pshhEsuhtshs.S+SsSlSSp.....ulosoCCoRRsK+..shpLsNushsu	........................lppK+NG.h.p.uLp.s.....Gs....t--p..hhsK..s.pS.h...FEpQHHHLLHCLEKTT...........................sH.EFlDEph.FppsshcsuhtshsoSRSsSlSS...ps.........u.lsooCCuRRtK+..sh+lsNushs......................................	0	18	27	59
+11713	PF11880	DUF3400		Domain of unknown function (DUF3400)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3996 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 50 amino acids in length.  This domain is found associated with Pfam:PF02754, Pfam:PF02913, Pfam:PF01565.	25.00	25.00	33.90	32.40	23.40	22.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.31	0.72	-4.74	20	251	2009-06-18 16:36:00	2009-06-18 17:36:00	3	7	245	0	83	236	35	45.40	65	3.53	CHANGED	SRYs-Ds.s..l-ADYIVVEMA+HlLGENWhs-YVt+ANsGGIERVLl	.SRYs-Ds.s...lpADYIVVEMA+HlLGENWhs-YVp+ANsGGIERVLl..	0	15	52	69
+11714	PF11881	DUF3401		Domain of unknown function (DUF3401)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2478 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 231 to 250 amino acids in length. This domain is found associated with Pfam:PF02145, Pfam:PF00595.	25.00	25.00	40.40	34.60	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.96	0.70	-4.97	11	199	2009-06-18 16:41:43	2009-06-18 17:41:43	3	5	38	0	83	145	0	232.40	45	15.83	CHANGED	K+hpusussh.upsRhRAoLRDlc.SPptstKSol--DlKKLIh..DSPsstpp+ch................s..sssSs.RRSLaRTLSDESlh.SGpRpsSauoScu.hL-QuLPsDlLFo......sSTLP..........Pp..shPhpp.uht.uhpsl+u-hSASDsSLsDh.-p.+th.h.DPGLMPLPDTAus..L-WSpLVDAA+AFE...................sQRss.Fsohs-s.ppupshpsstp......spphsspsspsh........hsuccSPss.....................LsGKVsQLEshLK	............................Kphpossppl.upspLRASlRDl+.SP+ts.hKSTlE-DLKKLIh.hDSPssEpp+ch................................s..ss.Ss.RRuLpRTLSDESlh.SupR-sSFuSstS.hL-puLPsDlLFo......sSThP...............Pp...shPhpp.u.ht...Ght..sl+...u-hSAS-sS.LsDh.-p.+....h.DPGLMPLPDTAus..L-WSsLVDAAKAaE.........................................................sQRus.h.su.s-s..pps.sh..tssps............ptssss.+sh..........ssu.c-u.Pss.....................LsuKVsQLEshL+...............................................	0	3	11	31
+11715	PF11882	DUF3402		Domain of unknown function (DUF3402)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2702 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 350 to 473 amino acids in length. This domain is found associated with Pfam:PF07923.	25.00	25.00	26.30	26.90	23.10	24.90	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.35	0.70	-5.42	22	336	2009-06-18 16:43:09	2009-06-18 17:43:09	3	9	231	0	228	328	0	384.80	36	46.72	CHANGED	PhulhEAsclaus+l+hohuh+QLWcER...-cFh+h-RG..........tsspp..s.s.-lpp.h.p.p.p.hhphst.p...pt..........ssppplp......hlptVEshYppsLspLpohlhVLL+hllushs.........................sphptts......shhsss.scp.s.t...................sh..pl-hhRt+EIssKAlSulLlLLLKWFKlSHlLKFEYhoQLLhDusalsLlLKhFsh.............................pshsphlss+sch...phsFaphC...........hh...........................................................................hs-.lsphuhssst.sptsht...a.shRNF.FSsINhL+IhpK.lsKpKspRhhhLspaKSSsILK+hL.KlspspLphYsLKlhKpQlPYpGRKWRp..uNMclIouIYLpsR.cL+D-WLsGsDl-u-hp-uhspEpALRuLlcaaNhRRY................................c.M........................sht...thtthhp....................................................................................Ept-hFhpph	....................................................................................tu..ass+l.+.pchpp.L.ppR...p+FhtaphG..........................................tssps..ssh..s...psl..p.cthpphppch.hhshschphp..pcth.................................................ttpc-lp........sssEhhYps....hLPsLsphhIsLLKllL..usss............................................................sspscspu................hNhhscshspphs...psh.......................psh..p.tlDlsRpKEIhsKAlSulLLLLLKaFKlsH........lhpFEYhuQhLl.uNhlPLlLKhFs..............................................................................Qsl.phlssKssh.........s.hsa.ptshtp.....................................................................................................hsE.lst.uh.sssssp........a.saRNh.FSsIN.hLRILpK.loKhKppRs.h................h.....LV.aKSusILK+sL.KV................p.shhpLYlLKLlK.Qs.YhGRpW..Rp....SNM+shoAIY.psRhcLpD.DWh...hG..........s...D..l.....Ducs...-h.s.p.EpsLRu.lcha....N.RRY.......................................................sc.h..................................................................shp......thpthht........................................................................p.......................................................................................................................	0	68	106	173
+11716	PF11883	DUF3403		Domain of unknown function (DUF3403)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2739 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 50 amino acids in length.  This domain is found associated with Pfam:PF00069, Pfam:PF08276, Pfam:PF00954, Pfam:PF01453.	27.30	27.30	27.40	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.48	0.72	-3.69	31	401	2009-09-14 08:07:09	2009-06-18 17:45:01	3	35	35	0	184	445	0	45.40	38	7.07	CHANGED	SEsssIPQPK.PGaCltRush-s-sSSSpph..s-ohTVNQhTsSVIDAR	.......o-ssplPpPKpPGaslt+s..sh-s.....s..sSSopp.....-shoVNphTholl-uR.........	0	18	139	156
+11717	PF11884	DUF3404		Domain of unknown function (DUF3404)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2879 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 260 amino acids in length. This domain is found associated with Pfam:PF02518, Pfam:PF00512.	25.00	25.00	27.80	26.90	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.61	0.70	-5.50	10	181	2009-06-18 16:46:17	2009-06-18 17:46:17	3	3	113	0	17	103	2	254.20	48	54.22	CHANGED	hlhus.AaAD..SLPE..RIDsFpphFshpsAspoYDlRplQusYPTpLLoPsShLPQTucYPLK-IQpLYplApTCpGphPL..SPLlTEPLVFTRAlC+GopLsscWFuRSGLIHPGGGSYAsRYlpKaP-pcppLtpaMHI+ERslAspspLLu+L.QpMss-uIsALluGushFls.s-ELWLR+GstYalaspssWpssssstsLshslhopsssCalppGNICWcl.ED+SclLpauhIhLllANlhLllG...WulYRWNsKRcEM+	.........................hlss.sphD..sLPE..RhslFhphh..ppuos.hs.polp.pYPptLLoscShhPphopYshpDIptLaphAppC......pu+hPh..SPhls-sl.FphALC+t.osLuscWFsRsuhlHPuGGoYAt.RYl.E+aPsp.tsL....hsahHlpcps.Aucs.....plL.ap.L.QphupsulsALluGhphalu.ss-LWLppss.......taalhspppWps.ssphslohs.hp.Ac.psChhphuNlCas...cspSclL......hhShllL.lhh.slhLlhG...hSlYphppc+pEhR...........	0	4	6	13
+11718	PF11885	DUF3405		Protein of unknown function (DUF3405)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3057 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 636 to 810 amino acids in length.	25.00	25.00	27.20	25.40	24.80	23.70	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.97	0.70	-6.26	25	217	2009-09-11 13:24:11	2009-06-18 17:47:24	3	5	82	0	180	215	1	433.40	36	68.33	CHANGED	lCF-RauRaGPY.....GhG..ht...................................................ps-+puhppsht......................pVD..W.cpV...........sWuphQpcChp+NppR.Fts..................pssphpshshsp...ttt.t.....tt...........................phsRTAlllRsapsapaT-cDlhhlRuLIsELSLpS.GGEYsValLlcVKD.sslt..Iaus..--sYp+sLc-s.lPtEF+uMssLWsEpphphhYPs.lpc.h..................+tsaputh.hPlQhFuhpaPEaDaaWpWEhDsRaTGHaY+hhs+lspaA+pQPRKuLWERNuRFYlPuhHGsa-.sFpphVcht...............................................................tu.ccslWGP.......p....tshss.PPss....cD..cYcWGVGEEADLIshsPlFDPp.sTsWlhcs-lpGY.stp...s.tsPRRAulITtuRlSR+LLtsMHcEshtt+HthhSEMaPsTsALa........HG..............hKAVasPHPVahD+pWssctlsphaN...uG.sssoGGs+sSsau.s+Epsh........+..GsoWaYsusaussLacRWLGa.chss....sGGc...t........hc.................stcGRhCLPsMLLHPlKc	.......................................................................Ca-RhsRhGPY.....Ghu.................................................................ppts.tt.htt..............................lc..a..ppl...........sWuphQppChp.tN.ttRFt...............................................t.t..h..ht.......................t..............................................................................................sRoAlllRsassh...pasppshh.lRuhIsELSLtS.GGEYpVahLlcV+-psh....I.asD..pcsYpphlpcs.lPtEFpuhshLWs-tththhYst.l.c..........................+slaputa.hshQhFu..hpHPEaDahWpWEhDhRaoG+aYchhs+ls.pau+pQPR+tLWERstRaYlPshH.Gsa-.sFpphlc...................................................................s..ppslWGP....................p...........t..shPPs..s.....pD.....papWGVGE-ADhIshsPlacP...sosWlhps.clhGY.ptp.....................sPRRssIlTtoRhSR+LL.sMHpEshhtpH.hhoEMhPsosALh........HG......................hKAVasPHPlahD......RpW.ss..p...htphaN.............sG.su...touu.tsSsau.tp....Epph..........p..GhoWaYputhsspLappWhGh.p.ss...tGGp.t........hE..............................ttpGRhCLPshLlHPlKp.............................	0	44	95	152
+11719	PF11886	DUF3406		Domain of unknown function (DUF3406)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3286 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 270 amino acids in length. This domain is found associated with Pfam:PF04548.	25.00	25.00	25.60	25.10	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.23	0.70	-5.55	9	103	2009-06-18 16:48:28	2009-06-18 17:48:28	3	3	27	0	72	111	2	243.70	45	26.62	CHANGED	sstPssVuVPhPDMsLPsSFDSDs.PsHRYRhL-ssspaLsRPVL-sHGWDHDsGaDGlslE+thslppphPu..osssQVoKDKK-sslph-uuhShK.HsEstoohsGaDlQolGKcLAYolRGET+FKNh++NKTsuGlSsTaLGDslusGlKlEDplhlGKplpLlsSsGsMpupGDsAYGuslEApLRcKDYPlupphooLGLSlhcW+uDLAlGsNLQSQh.lGRsSphss+hsLNN+toGQlolRssoSEplpIALlullPlhtulhpphps	.............s...ttssVPhPDhsLPsSFDSDs.PsaRYRhL-s.ssphLsRPVL-scGWDHDsGaDGlslEpshsltsp......hPu..uhssQloKDK+-hslph-susuhK.as-stoohsGhDlQo.lG.+pLuYslRuET+F+Nh++NpTsuGlShThlGcphssGhKlEDplhlGKRltLVsssGshpup....GDsAY..GushEspL+t+DYPlsps.uoLuhSlhpW+.t-huluuNLQSQhplGRsoph........ss+ssLNN+tsGQlol+ssoSEplQIALlullPlhttlhpph.........	0	13	41	56
+11720	PF11887	DUF3407		Protein of unknown function (DUF3407)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3559 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 360 to 454 amino acids in length. This protein is found associated with Pfam:PF02470.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.60	0.70	-5.11	43	1339	2009-06-18 16:50:23	2009-06-18 17:50:23	3	3	164	0	385	1189	0	215.70	19	52.68	CHANGED	psLsslLcplDPsKLNuTLoAlApALcGpG-clGpulsshNslLtplNPphPslpcDlpsLsslu-sYu-AAsDllssLcsuoTTSpTlssppssLDulLlussGhusoGs-lLssspssLlcusssLtPTspLLscYSPthsChlpGh.tthssthtcshG.G.NGhultlsss...............................................hlhGss.PYpYP-sLPplsA.+G.G.tt.PuCh...sLPc..sscs.....a......Ps.hLV.ssTGh.........ssssa.p..............s.sl..................GpPhhtpal................h.Gst.sGsss.........................................................................ssP	.........................................................p......lsthlssh....upul.s...G.p.G.spls.psl.......sphsplhspLs..s...ph..s.s..lt..p..s...lcsLsslssshucsssslhphlsshs.s.sspslssppspLsshLt.......shsshuss.s.s......shlspspspLhp....sls..pL.ss.sh.phLsphs.s.pl.p...h...lt.h.......h................................................................................................................................................................................................................................................................................................................................................h................................................................................................................................................................................	0	62	221	326
+11721	PF11888	DUF3408		Protein of unknown function (DUF3408)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3594 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 128 to 160 amino acids in length.	50.10	50.10	51.50	51.20	49.70	49.70	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.72	0.71	-4.24	32	653	2009-06-18 16:51:41	2009-06-18 17:51:41	3	1	126	0	52	483	10	133.40	20	94.25	CHANGED	sppplccctlhchhttts............................spsssptsssscpsppppssts......................t.ptpppcts.p-YcppFL.pssplssRps..lYlsc-l+-+ls+llpsluttcholuual-NlLpcHhcpap-pIpphhppphp...........a	.....................................................................................t.................................................tt.tt.....t.p...tp.tttt.................................tp.tttpp+tphp-YcptFL..p..ssc..hp..sRps..lYlsp-h+c+lppllpslGp..pcholuual-NlLccHl-pap-cIpphhtpp....ph......	0	20	47	52
+11722	PF11889	DUF3409		Domain of unknown function (DUF3409)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3824 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in viruses.  This presumed domain is about 60 amino acids in length.  This domain is found associated with Pfam:PF00271, Pfam:PF05550, Pfam:PF05578.	32.40	32.40	56.90	39.50	28.30	27.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.84	0.72	-4.27	8	239	2009-06-18 16:53:22	2009-06-18 17:53:22	3	16	46	0	0	263	0	55.50	75	2.50	CHANGED	Dcsus+p+cKKPDRl+KGsMKIsPKEoEKDSKTKPPDATIVVEGVKYQVKKKGKV+	........-cGAsspKppKPDRlcKG+MKIsPKEsEKDSKTKPPDATIVVEGVKYQVKKKGKVK........	0	0	0	0
+11723	PF11890	DUF3410		Domain of unknown function (DUF3410)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1956 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 90 amino acids in length. This domain is found associated with Pfam:PF02826, Pfam:PF00389. This domain has a conserved RRE sequence motif.	27.20	27.20	27.40	27.40	27.10	26.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.84	0.72	-4.33	64	939	2009-06-19 10:12:49	2009-06-19 11:12:49	3	4	934	10	136	570	33	80.40	53	21.55	CHANGED	slLPss.lsplslstph-..ps.sLtpLs+hlYDlRcDDuhh...R.csh............tpssuFDtLRKpY.....RREaSuLpl.t......spspss..hphLptLG	.....................t.LLPsPphu+lsLc..u..sLD....ps.TLK+LsHLVYDVRRDDAsL...R+su...................uhPGpFD+LRKNYh...-RRE.WSSLhV.h......s-ctss....AulLscLG.................	0	28	58	100
+11724	PF11891	DUF3411		Domain of unknown function (DUF3411)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1986 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 168 to 186 amino acids in length. This domain has a conserved RYQ sequence motif.	25.00	25.00	30.40	26.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.01	0.71	-4.58	14	218	2009-06-19 10:19:12	2009-06-19 11:19:12	3	6	31	0	146	212	4	165.50	34	39.91	CHANGED	sRhLADPpFLaKluhEpslshsssshuEhppRt-p.Fh..sEh-hshsshlsuslsshhlValhAPshuhsssus..su................thpthhtslP.sNsFptuh.shppaoltpRluolhhKGsphusVGhsuGllusuluNsLhst++thp.....pp......sspsPPlhpouhsaGsFhGlSuNlRYQllsGl..-	........................tRhLADPp.FlaKlshEpslslsssshu-hppRtcp.Fh...pEhDhshssllhuslsshhlVaL.APshuhtssss.......................thtthhtshP..sshFptuh....shp.p..asltpRlushhh+GsphusVGhsuullGs..............uloNsLhsh+.+php.....ps.....................sspssPlhpsAhsausahulSuNlRYQllsGl.......................	0	38	100	128
+11725	PF11892	DUF3412		Domain of unknown function (DUF3412)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1106 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain is found associated with Pfam:PF03641.	25.00	25.00	32.00	58.30	22.50	20.80	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.63	0.71	-4.29	49	901	2009-06-19 10:27:43	2009-06-19 11:27:43	3	3	892	10	132	465	51	123.00	71	27.74	CHANGED	uMppV+paR+spuDAYpFNWSL+Ip.-FQhPF.PTHEsMAsLsLHhsQsscpLAANLRRAFSGIVAGNVKp-GI+tIEcaGPFcl+GDspLMcthDpLLpuFVpQpRMKLP.GotY.PCYcI.ss	.......MPhVKEpRR-TGDAYSFNWSh+IsPDLQhPFEPoHENMANLcLa.D.QPsElLAAsLRRAFSGIVAGNVKEsGIRAIEcaGPYKIpGDt-lM++MDcLLQuFVAQHRMKLP..GSAYlPCYEIs.s...............................	0	23	53	95
+11726	PF11893	DUF3413		Domain of unknown function (DUF3413)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1403 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 250 amino acids in length. This domain is found associated with Pfam:PF00884.	27.10	27.10	28.60	27.80	26.60	25.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.56	0.70	-5.50	39	977	2009-09-14 14:01:40	2009-06-19 11:32:37	3	2	864	0	128	567	33	247.20	52	42.40	CHANGED	Mlpptp..pa+-clSphlsWGHWFuhFNlllAhllGsRYl.hhssa........PsThlGhh...YhhlShlGHFoFLsFhhaLlhlFPLoalls.p+hhRslusllATlulslLllDT.laspashHLsshVacLlhsstp.spls....tpWthhal...shPl.Illlphhhupah...Wc+lcplp+p.+.hG+hluhhhhhsFluSHllaIWADAshY.pPIThQcssaPLSYPhTA+oFhcK.aGlLsppphppphptptpsps.........plpYPlpsLphs	..........................................................................MVsppp..pYRE+VSQhlSWGHWFALFNILLu....hllGSR.YL.FluDW...............Ps.TL..sG+lY.hl.S.hlGH.F.SFLVFAsYLLlLFPL.TFI...V....h.....Sp.....R...LhRF.LSsIlAT.AGhTLLLlDoEVFsRF+LHLNPlVWpLllNP-p.sEhu.....RDWQ..L..hFI....ulPl..IL.LlEh..lFAsWu...WQ.K..LRSLsR+.....+...auR..P..L..A..Ahhhlu...Fl..A..S...H.llYIWADAsaY.RPITMQRANLPLSYPMTAR+FLEK.HGL..LDuQ....EYpRRLhE..QGsP-Al.........ulpYPLspLca.p........................................	0	26	53	93
+11727	PF11894	DUF3414		Protein of unknown function (DUF3414)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1638 (release 23.0)	Family	This family of proteins are functionally uncharacterised. The family is found in eukaryotes and has a conserved LLG sequence motif.	26.40	26.40	27.00	26.90	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	1691	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.42	0.69	-14.40	0.69	-7.68	32	424	2009-09-11 06:03:47	2009-06-19 11:35:43	3	13	249	0	291	403	2	1089.40	19	83.73	CHANGED	hWss..hcpLapslp....hhsppp.psl..ppL..pLcpht.shhsLLcpPs+sspsRpplp..............pGtlphuctschplsp-hlppulhLuDtLsLcEltAs-Llh..supppp....th.uhshh.sAllhYaptRphlLssL+hlhptt.t....phs.....p-l.pchhphh..........................pahcphltshshlcphLshls-.ls..............tsplh..sphp...shs..cphchh+s..........hlhcp+chLuthLashspp...shhstsshhpllptLpp..l.......sshDtlhlthlsulltsh.............................................tss.pthshhsscphtpslpsclpspt........................Wth.shpuslhhhahshhtuhsptssstts...shshpccs-...phhppAlp.............sGuhcaLhthshcs........p..t.....thh..L.pt.s.................................................................sshh.....cp....................................hhhpphcshlpshI.sshs.hlpcL+scE--sths..st.p.s.s.s....................................................................shptcLEcFhlhluhhYpscP...-huhp.aWssp-..ssh...............................htFlpaAuchtssslh.ssahcMLsuLos.G.psAptsaphLppss...........tt.tsloWcphFpsLphYhpplp...........p..spspsl.hspss.psh.................stcphhhLsuaLpLlsplspp..s.pssR.tl.......hcpssap..ssllhsLhps..........slP.tL+As.....................................lhpsLuulh..........s+s.ptutplWptlDphhhtsshtsss.t.....................pshshptc............hpthpshtppaststuFlpLlpsLlpst.....t.......h.aPpsLGsu..........................hR...hsGlpPYlc....Flhsplhhc..spshtcsspphplt.ssLchhhpsLpsas.s.....hl.thspsts.......................sh.salt.p.Puhtlh.phLhspchhphlhsll..ppussplsphst.....p.ltpslhhuLpllshsLphQssahchlpsslp.........................................s.hhtshshhhp..ulssh.cth.hplsllshh.LahusspspluhsSl+ILpplupp.phs...............s+llslhsp...tspupcIptuFlppl-sp.sp.tt.................................................................tt..hplKhpILshL.ssLstts..pPslAHhLLGFcsp.tshhphs.p..shhsstpohL+ulLslLpphhsshps..........lshh.scLsphshpllhpLCp..sshoSthsLpalRs.....ssalhphlpp.Phls..hhhps...............................ussshhshLphRu....hlhphhulEl+s..huhpuphoptpplhshLls.............tphspsstsh..sp.........................................................lhslLDhlshsh....pphs..plshacs.hslp.shpp..........hpspt..uht.......lhs.hphLppllphchpshps.h..........p.sptp.l.....pEhptllpahsphNptpphttsphphLcSWsQLlplllssss...hsssp+pshIl-slphllsKlp...h-....shthu.plsplshsLhstlcpshh........................................ttphsshhss.............+La...lhpshlcuIhpss.us.pLRsshYshhhpYLptlhcsc...................................................hpcpshpllcshGccLl-slCsDAhsGcshsRhtAlhlL-sLlpl....s..............psshllphlspssaLplllcSl+pp-ttLps................hhs.sshhhtLh...........hacuplshLhRlApo..+pGAptLlpsslhphltpsphhshcP.Dlslc..hhcp.................................sss.hppaaplLhPsLplhssllhSh.................G.p.....scpshtpshpaLt...pppchlhull+csshht.........................................t..tthspht..pptl.plspthhllpshpp	...................................................................................................................h....l..p............t....h........p.....tp.+t.l..........................tt.h............................h.ls...t....sh.lus.hplsEh.shthhh...........tu.tt...........................s.....hh.a.a...tpt.hht.h..hh............................t....................................hh.thh.t.t.h.t.h..htt....ht...........................tt.........................t...................................................h.p....ls..lh...............h..hht.htt...................................................t..p.h.......h.hh......hh..h..............................................................h...h.............................................................h...h.h.h.h.h..h.....................t.............h...h........................tsh..h...............................................................................................................................................................hh...............ht..c...t................................................................................................................................ht........hh...h..ha..................p.s.....hh.......................................................t.Fh.............t...............h..shh.hltsls.........s..su..haphh..t...........................hs.atthht.h..a...hp.........................................................................................t..............................................................tp..hl.shhtlhttlh.............t...................................hhthht................h...lhut.....................................hh.hltth.................t..hW....l.c..................................................................................................................t..h..p...pth....shhthh..Lh...........................t...........................................t.......h..hhp.....hh..h.h...................h...t..p.h...........l....hphh.....l..h.....................................................................................................hh.ph..tt...hht.hh.h..........h...................................................sh.hh........hh.hp....h.t.h..........................................................................................h.....................h...shtl.h..h.........................................hh..h..........tl..sh..t.h.............................................................................................................................................ht..lhthh..sht........shshhLLthp..........................t.......................ohhpsll.h..h................................h.t..htlh..Lh...p...ss..hh..hp........thh...h.........................................................h......t.....hhphhsh.h...............t................hht.l......................................................................................................................................................h.phhp.h...........................h.....ht.....................................................................hp...h..h...hh.........................................p.....h....h..................hht.....sW.phh.h.h....................................hh.p.h...h..........................h.t....h..h...h............................................................................................................................................h....hh...h..h..................h....+...Y..h....hh.hh..................................................................................t....h..t..s.tthhphl.pDs...stt....ph..uh.hlt.l..h........t...................t.hh..h.p.shh..hhp..l........h...................................................................hh.s.h.hh.phst.....G...lht.thh...h...thht.......p...........t......................................................................................................ph.thh..hhplh...shh......................................................................................................................thh.hh..........h..hhp...................................................................................................t....................................................................................................................................	0	108	169	246
+11728	PF11895	DUF3415		Domain of unknown function (DUF3415)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1962 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length. This domain is found associated with Pfam:PF00141.	25.00	25.00	25.00	27.40	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.76	0.72	-4.11	35	127	2009-06-19 10:41:03	2009-06-19 11:41:03	3	2	39	55	5	183	0	77.90	45	21.94	CHANGED	sKhpssFpsshpKLulLGpstssLlDCS-VlPhPtPsssp...AaFPAGpohpDlE.tACsssPFPoLsoDPGPsToVsPVPss	....chtssFpsshtKLulLGpctssLlDC..SDVlPsPhshssp....uaFPAGhohsDlE.pAC..sp.oPFPoLsoDPGPtTolsPlPs.........	0	3	4	5
+11729	PF11896	DUF3416		Domain of unknown function (DUF3416)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_601 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 190 amino acids in length. This domain is found associated with Pfam:PF00128.	25.00	25.00	25.00	26.10	24.40	23.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.28	0.71	-4.34	88	711	2009-06-19 10:45:08	2009-06-19 11:45:08	3	10	684	18	232	658	95	186.60	32	25.33	CHANGED	stsRlsIEsVpPtlDsG+assKtlsG-.lsVpAclFpDGHDtluAsLhaR...........tsss......ps....Wp...................pssMp....h......uNDRWpupFsssp.Gpapapl-AWhD.auTW++slp+KlpAGt...-lsL-Lt-GutLlpcAst.pst...us.....ppttLpp.hsstLps..t..ssspp...luhhLssclsplhspts.R.shsTp.sp.hslhV-Rc	..............h..sRlsI-sVpP.l-s.....GpaPsKtllGE.lsVpAslat-GH-tluAsl.h.h+...............................sstt......pt....hp..............................phsMp..............sh......GsDpWpuphs..s.................cp.GpapapV-uWsDsauTW++shptKlsAG.............-lpl-LtEGstLlpcAsp.pss.....ts......................stp...sL....p....t...s.......sssLps..ts..........ssss+...luhhlssplsplht.pt....s.........R.phlop.utshs....lhV-R......................	0	62	140	191
+11730	PF11897	DUF3417		Protein of unknown function (DUF3417)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_724 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 145 to 860 amino acids in length. This protein is found associated with Pfam:PF00343. This protein has a conserved AYF sequence motif.	25.00	25.00	25.60	43.50	22.70	21.70	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.79	0.71	-4.15	79	640	2009-06-19 10:53:20	2009-06-19 11:53:20	3	8	576	0	243	588	45	116.40	36	14.10	CHANGED	shpphs........Vhsp.LP....cpLptL....p-LAhNLaWSWpscspsLFcplDspLWcpss+NPVthLtplsppcLcplupDtsalschctlhpchcpYhss..spWapp....sptt.spslAYFShEaGlp-oL	..............t.pphsVpspLPcpLptLs-LApN..LaWSWs.cspcLFpplD.spLW.c.p..ss+NPVtlLtpls.pRLcpLupDpsFlpchcplhschcsYhst....hWapp..................sstt..........ssslAYFShEaGlscsL.......	0	92	186	230
+11731	PF11898	DUF3418		Domain of unknown function (DUF3418)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1028 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with Pfam:PF07717, Pfam:PF00271, Pfam:PF04408.	25.00	25.00	25.60	25.50	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	586	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.63	0.70	-6.12	105	1852	2009-06-19 11:18:30	2009-06-19 12:18:30	3	22	1658	0	364	1658	366	534.70	42	45.93	CHANGED	K+pGpVhAhE+lTLYGLslVscRpVsYupIDP...ttuRElFIRcALVpG-h.....pT+t....sFhpcN......pcLlc-lEcLEcKuRRRDlLVD--sLasFYDpRlPsclssspsF-pWaKptp....cppPc...LLhhs+-pLhpcpustlostpaP-thph.uslcLsLoYpFEP......GpscDGVTlpVPlslLNQlsspth-WLVPGhhcE+lhALlKuLPKslRRphVPsP-aA...cuhltp..........h........pst..................ps.....sLhcuLscpLp+ho.Gl.....plst-sach..sp....LPsHLphsF+V...lD-cG.+.......h.............lupGRDLstL+pph.tspsppsls....psu.......................................................................s.s.....hcppulps.........W..s.FGsLPcphphc...p.u.G.....hpl.puYPALV....Dps...s.......uVulclF-sttcAppsp+tGlpRLlhLpls.s.l..KhLc+...pLPst............................scluLha............ssh.........Gps.ptLh-D.............hlssulcphhh....pt...s............................hs....psppsFpphhccsR........ucLsstspclsphlpplLsthppl...........p+pL+....u.phshsh.shuhs..............Dl....c...pQLspLlhtGFlspsshppLtchsRYL+AlphRL-KlstsP.sRDptphtclpsl.ppap.phhsp..h.t.up.h......sspl.pchRWMlEELRVSLFAQpLGTshPVSsKRlpcthppl	.........................................................................tpGuVhAhE+VTLYGLPlVstRtVsYupIDP.........s...huRElFIRpALVEG-a.................................pT.+a......sFapcNh+LhtElE-LEcKoRRRDlL..VDD-sLFpFYDpRI....sp-lhSu.........ppFDsWWKpsp............................cc..s....Pc......LLshp+s....Lh....p...c.s.A..p..p....lop.saPshWcp.....G..........s.....l......cLtLoYpFEP................Gs.s..s...DGVTVclPLslLNQl....p.t....psF-W.lPGLRcELlhuLIKSLPKslRRshVPAPsaAcAhLspl...................ssh..................ph.................sLlcsL.t+pL++hT...GV..............plst--W...p...h....sp....lPsHL+hsF+l...lD-...+s.+.........t............................................Ltcu+sLttL+ppL...ts...p.s...p.pols......tsA............................................................................................s..s...h-pp.s.l.ph........W..........s...F..GpLPc...p...hptc.....+.u..s.....hpl.puaPALV..........Dct.....c...............uVul+.lF-s.h......-t..ppuhhpG.l+RLlhLsls.sPl..KaLpc....pL..Pst.......................................................s+Lu.Lha.......sPa.................................Gpl..pLl-D.............slss.ulDpllt....tp..u.............................................................l.hsctsFttLt-c.lR........ucLsssshclu+plppILsthhsl................................................p++Lc.....u...phshsh....shuls.....................................................Dl...+...sQlssLlapGFlstsshpp..Lsch.RYLpAlphRL-KL.s.s..s....P...pRDpt...ph...hclcp...ltp...tap...phhsc........hs......stt..........stcl....p-lRWMlEELRVShFAQpL..GTshPlSsKRlhpshpp................................................	0	97	210	297
+11732	PF11899	DUF3419		Protein of unknown function (DUF3419)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1329 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 398 to 802 amino acids in length.	28.20	28.20	28.30	28.30	22.10	25.20	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.08	0.70	-5.74	42	261	2009-06-19 11:23:06	2009-06-19 12:23:06	3	16	242	0	167	284	73	367.10	30	64.16	CHANGED	tshhcchashhap........shlYsphWE.........DPclDhpsLpls....sscpllsIsSuGsNhLuY..LstsPsclpAVDLNPspstLlcLKlAAh+sLs.apsFachFGcupp.......ps.pplhtppLsPpLssputpYWpp+......t+phs..hhs+GhYcpGhhGp.hlths+.hls+lhGl....plcpLhpApolcEQRphapp+.lpslh.s..pllphls.........sphhhhhuL....GlPssQhshl.................................................tsss..lhphltc+L-tlhssh.l.p-NYFha.slstpYst.........sshPsYLptcsappl.......+sss...-plclassslp-hLtphsssolsthlLhDu.DWhss..............................splss.hpp.lsRsspsGuRVlaRoAutp....................shh.tph............cphsapsctusthpst.......DRsshYuuhalhp..ct	.................................................................................h......hat.hhs.......thlYs.sWEDPclDhchLpls....ss-..pllsIsSuGsNhLsY..L.....psP.t+lcAVDLNPsQstLL-LKlAuhp..tLs.ap-ha..............chFG..cupp................s.shpplh.p.c.LuP..pLsspuhpYW.p+......hphhs......hhsculYcpGh.tp.h.lphs+..hlh+lh..G..l...........plcclhpup.olpEQRphapp+......lpshhhp.........hhlphhh............sphhhhhuL....GlP.sQhs.hl.........................................tsts..lhphlhspL-.lhpph.l.p-NYFhahsltG..cYsp..........pshP....sYLp.csatpl............+sss...-plclHsssls-h....lt....p.h.ssso....lshhllhDshDWhss....................................pphsp.hpt.ls+s...h.p.s.GuRVlhRoAuhp....................s..hh.tph............cp..hsapsctssthtst..............D...RsshYuuhalht..h...............................................	0	55	102	139
+11733	PF11900	DUF3420		Domain of unknown function (DUF3420)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1362 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00023.	25.00	25.00	25.90	25.50	22.90	24.80	hmmbuild  --amino -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.33	0.72	-3.86	26	221	2012-10-02 12:10:21	2009-06-19 12:25:11	3	20	51	0	50	251	0	49.20	42	12.95	CHANGED	DLDsloLEKpLP.-VlcpIcplRhp.t..........phsth.........sshp-K+l+RIH	..slDsloLEKpLP.EVlcKIctLRtpst...............sppsphsth......................sshc-K+IRRI+............	0	6	27	37
+11734	PF11901	DUF3421		Protein of unknown function (DUF3421)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1420 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 119 to 296 amino acids in length.	26.20	26.20	26.80	26.60	25.80	26.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.51	0.71	-4.37	49	531	2009-06-19 11:28:17	2009-06-19 12:28:17	3	18	87	0	352	549	3	104.40	31	58.48	CHANGED	huGpD.su..tslYVGRuh+pGshlPuKVlPs.+ttsalsaGGpEhttps..aEVLssssh........pWl.sssGslP.....sAl.sGpotp.GEsLYlGRupapGslssGK.lp.SHtshYIPasGtElp.hs	................................h.......t...haluR.s.h.ap.s.sh..lPu+lhsp.pt.hsahsa.s.utEht.....hpp..aElLsstth................pWl..sss.s.G.p.l.Ps.....................sAl.uG.....pss.s.....G..E.sLYlGRuh.a...p.G..slhsGK..lp.s...u.+.t...shalsasGtEht........................	0	119	159	290
+11735	PF11902	DUF3422		Protein of unknown function (DUF3422)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_513 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 426 to 444 amino acids in length.	25.00	25.00	38.00	37.70	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.31	0.70	-5.60	78	308	2009-06-19 11:40:50	2009-06-19 12:40:50	3	3	279	0	144	330	270	407.80	35	95.89	CHANGED	hpsHPL..RtsLtsElHARPa.hlssPtplsalAhh.......sspppss.-tspLssLtpphGhs.P.........sssus+aths.hGt...hpL+WEpHTEFsTYThht......sssspsFssss.....hshhP.....tsWhtphPG.....phlsusclplt...stssssptt.....h.ph.F.........................sspoLsuSpltsGsAhlhoDFRl.cscGasRhlV..hspslsstphGRlVQRLlEIETYRhhALLuLPhA+plssplsph-ppLuplspphsss...ssss-.............plLscLoplAAclEshsAposaRFuAopAYttlVppRlppLREp+ls.GhpThsEFhpRRhsPAM+TCpuspcRhcsLScRlsRAusLLRTRV-lphppQNppLLpSMs+RuclQLRLQpTVEGLSVsAISYYsluLluYlhculptht.....ls.l.s..hslhsul..ulPlVlhsVWhslRRl+++ht	....................................................................................................................h..tHPhRttLhsElHARPa.hlssPtplhalAhh.......................sstptst.cpstLtpLspphGhs..P.........ptsusHathp.hGt....hpL+WEpHTEFsTYTahts...........sssstsFssss.....hthhP...tsWhtphPG....phlsulclplh....stsssstth........ph.F.............................ssssLssSpV....t.....sG.....sA.........tlhoDF+l.cs-.....GasRhLl.....hs.pshsspphGRllQRLlEIETYRhhALLuLPhA+phsspLsph-pp..L...sp..lspphsss...ssssc.........................pLLscLopLAAclEshsApotaRFuAopAYtplVppRlppL+Ep+lt.GhpThs-FhpRRhsPAh+TCpuspcR.psLopRlsRAssLLRTRV-lphcpQN.......p.......pLLpSMscRAclQLRLQpTVEGLSVsAIoYYsluLhuYhhculpt....ht.......hs..l.s.splhsul..hlPlllhsVWhslRRl++ph.h.................................................	0	33	80	106
+11736	PF11903	DUF3423		Protein of unknown function (DUF3423)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_670 (release 23.0)	Domain	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 73 to 118 amino acids in length. This protein appears to be related to ribbon-helix-helix DNA-binding domains, suggesting these proteins may also bind DNA.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.31	0.72	-4.22	57	485	2012-10-02 18:44:02	2009-06-19 12:44:36	3	2	458	0	138	370	49	72.40	32	83.02	CHANGED	huhVKIsD-La-plRpsupshsRSIsuQhEaWh+lGhlsE..hsPsLsas.............................tltphhhpts........thphsph	....sll+Iu-pLa-slRttupshSRSlNuQhEaWh+lGhhsE...pPsLsap.............................tltphLhptt..............sh....................................................	0	33	66	106
+11737	PF11904	GPCR_chapero_1	DUF3424;	GPCR-chaperone	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_942 (release 23.0)	Domain	This domain, and the associated ANK family repeat Pfam:PF00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.	25.00	25.00	26.20	25.90	22.10	24.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.10	0.70	-5.28	39	534	2009-06-19 11:46:30	2009-06-19 12:46:30	3	13	131	0	299	479	1	286.90	32	59.12	CHANGED	RlDoTLhGF-.sh.......phpRucpSalF........cG-ssss...........plh.ls+cc+hlhsthhph............sttttcpplssh..............hpsslhsstlcspphshpcs................huW..Rp-+sEhl.s...sacu+lYsh.psV.l.h+pR..............................p-+Loc-pptphcs......................tpsshpshhs....................................-pph..........................................s.phpp.....shssss.sshs.c.phhsst...pht..spshG+...............sh.c.......sppppph+sslWloc-FPLp...............h.-pllPllDllA..sspthp+L+-h........................................loh...cLPs.GFPVKl...............................pIPlh.slpAtlTFspapthp..........................................................................schppshFpIPssYph	.......................................................................................................................RhDsTLhuFp.ph..........phpRGphSalF........pGpssss..............slh.lsHcp+hlhsthht............................sttp.ctplshh......................hsos.lhsstlcscp.l.sFp+s.....................huW...Rp-Ks.............EhV.s...sac.AK...........VYsh.s..sV.l.s+pR...........................................................p-HLocc-pt+.cu.........................hpshpphhs.......................................ppph...s...........................................................................................................t..hpt...........sh...ssss.s...slo.-..-Yhsst...........p.t...s.phG+............................h..th.........ppppp.pF+..AslWhsp-a..P.Ls..................................l.-plhPll-lhA...sstths+LR-F........................................lph...cLPs.GFPVKl...............................-....IPlh.slsAplTFtphphh.................................................................................t.p.p.FtlPtsY.........................................................................	0	80	134	207
+11738	PF11905	DUF3425		Domain of unknown function (DUF3425)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1128 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 120 to 143 amino acids in length.	27.10	27.10	27.80	27.50	26.40	24.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.10	0.71	-4.27	62	451	2009-06-19 12:01:03	2009-06-19 13:01:03	3	17	80	0	392	468	1	130.20	22	31.52	CHANGED	sthlu.a................h.sstts.tp.lPs.tLpPTt.Qh.....plPHtsh.lDhl.PaPphRDpLlpthpp...............h-ps.....chhp-hhss........................................hsttshtt.........................................psshlhh...tc...hc.psWEloptFhc+as..............hlhcut...phh.........ospa...Rt	..............................................................................................................s...t...tp..lP..tLpP.T..hQh.....................ph.PHtsa.lDhl.PaPphRDpllt....thst.....................hsps.....phhtshhss.........................................................................st..................................................................................................pss.hhh...tc..shchpsWclsttFhc+as..............hlhpst....................................................................	0	75	180	332
+11739	PF11906	DUF3426		Protein of unknown function (DUF3426)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1212 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 262 to 463 amino acids in length.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.78	0.71	-4.54	92	481	2009-06-19 14:23:17	2009-06-19 15:23:17	3	4	476	0	190	502	91	144.30	22	40.45	CHANGED	hsshhlhss.LhuQhsah..RsplsphhPphpshhpt..h...C..lGCpls...hslpslp..pt..shcphs.......sssslhlpuslhNpuchstshPtlcLslpDtpsp.lhp+sh..............P.tpalt.t........pst.....lsssps....hplpl......plp...ssss........pAssaclphh	..............................................................hshhhhhsLssQh.saht.ts..plstt.Pthp.shhpt...h........C...l.s..Cp......lss..hshptlp.h..ps...slcphs................ttsshlhlpuhlhNpushs.shPtlcLsltDtssphl.sp+hh.........................................tP.tpYltst.....s.......pst...................lsssps....hphtl.......plt...ssss........psssaplph....................................	0	50	121	156
+11740	PF11907	DUF3427		Domain of unknown function (DUF3427)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1236 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 243 to 275 amino acids in length. This domain is found associated with Pfam:PF04851, Pfam:PF00271.	27.70	27.70	27.80	28.50	27.10	27.40	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.81	0.70	-5.45	60	723	2009-09-11 10:09:40	2009-06-19 15:27:28	3	13	675	0	139	602	88	256.20	25	28.44	CHANGED	ph.lsppl....st.p.hth.hlt.hh.........................t.hthtph.p.lpp........t.........tphhphLphpaasspt......................hpht........hhplspphpphlpss...........thpp.lt-llphsl......pp.......t.......sslplapcYoRc-lhthls.hspspss.....htGhhhhps....pspslFlThpKs-c..hSsospYcDhhlspphF+WpSpsspshcSscspphlpppcp...Ghp...lhLFVRcps....uhsts.FhaLGps.phss......pp.................uppslshpacLc...pPlssslachhsp	....................................................................................................hhotphhsuh+.h-.hlLc.lh...........................................pp.p.hs..h.pp.h.p.h.pt...h.hspt.........shp...s...shphLshsFasss...........tph...........hlphpt........hhplspthpph..Lpsp.................tFpthlpDllchuh....pt........p..ttp.....ssLhLap+YoRc-hs+lhs...asps.tsus.........hhG.Yhhtpp.........phslFlTacKp-c..hssss.......pYcDpals..ppph+Who+ss+.slc.Spcsppllppctp...shp....lhlFV++pc.........sput..FaYLGps...phlp...ts..................tupssVshshpLc...pslpsclachh...................................	0	49	95	121
+11742	PF11909	NdhN		NADH-quinone oxidoreductase cyanobacterial subunit N	Coggill P	anon	Lonsdale D	Family	The proton-pumping NADH:ubiquinone oxidoreductase catalyzes the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides. Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 subcomplexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1]. The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms [2].	25.00	25.00	60.10	59.90	21.10	16.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.59	0.71	-4.89	20	98	2009-06-19 15:22:00	2009-06-19 16:22:00	3	1	89	0	45	90	139	149.60	50	87.57	CHANGED	M...sLLh....oGppFh+........DLEpsGuLAlasPLEGGhEsRhLRRLRAuGYpohhhSARGLGDPpsaLhplHGVRPPHLG+pslGpsuAlGcV.hV.P.ls....pL..ssuKuLVLWlLEGpVLSpuELphLssLsppEPRLKlVlEhGGsRslRWpPLpph	.......................MsLlhoGptFlcDLEppGuLAlYsPLEGG....aEGRYhRRLRusGYpshplSARGLGDspsaLhplHGVRPPHLGKpslu.ptuAlG.laalPP.lshpLppLsssuKGLVLWllEGpVLScuELpaLstLsph-P+lKVVlEhGGtRpFcWpPLpp.h.	0	8	29	40
+11743	PF11910	NdhO		Cyanobacterial and plant NDH-1 subunit O	Coggill P	anon	Lonsdale D	Family	The proton-pumping NADH:ubiquinone oxidoreductase catalyzes the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides.  Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 subcomplexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1, 2]. The three nuclear-encoded subunits NdhM,NdhN and NdhO are vital for the functional integrity of the plastidial complex [3].	25.00	25.00	31.40	47.00	22.00	19.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.12	0.72	-4.34	21	95	2009-06-19 15:36:07	2009-06-19 16:36:07	3	2	89	0	43	93	99	69.00	52	67.02	CHANGED	lKKGuLVRVsREthpsSlEAtASDsphP.....sYlFEusGElLsl+....GDYAQVRa.phPsPsVWLRlDQLEsh	...lKKGsLVRVs+EphpNSlEAtASDs+hP.....sYlFEspGElL-l+.....G-YAhV+a.tlPTPslWL+lDQLct...............	0	7	27	39
+11744	PF11911	DUF3429		Protein of unknown function (DUF3429)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1072 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 147 to 245 amino acids in length.	39.10	39.10	41.90	41.30	34.60	37.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.95	0.71	-4.21	83	410	2009-06-19 16:34:30	2009-06-19 17:34:30	3	3	382	0	189	393	578	145.90	27	71.46	CHANGED	tpsPphshh...LGhuGLlPFlhsshhhhhs....shtths...........................shhhhlsYuAlILSFLuGlhWGhuhptt..............st.shhthshullsuLhu......W.....sshhh....sshh......uhhhl.hhGalslh.hhDhthhpt....shsPsWahpLRhhLTsllshslhlshhh	...................p...Pp.shh..LGhAGLlPFlssslhhhhh.....sh.h.t............................hh.h.lsYGAlILSFLGGl+WGhuhstt........................sphsh.hphshu.llssl..hu......Wssllh.........ssth......ullhl.hhuFshlh..hhDtthhtt................thhPsWa.hthRhhLThlsshslhhslh.s...........................	0	58	110	145
+11745	PF11912	DUF3430		Protein of unknown function (DUF3430)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1305 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 209 to 265 amino acids in length.	28.60	28.60	28.60	29.00	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.36	0.70	-4.51	51	133	2009-09-11 05:55:51	2009-06-19 17:37:34	3	6	4	0	133	133	0	208.80	16	78.26	CHANGED	MKl.....hh.llll....llhlhshh.................hssph...........lshh.Pap....sspCs....................................sss.GhG........as........hsp.Chths..................hhhhptssssshhphphhp..........ttsCt.....ts.hss..hshp....hssCht..................................................st..s.............hshhhhsss.ps.h.....sssoh....lthhh................................ss................pCsss.......shhhhtahssspp....l........ssshohpahCss......sh.shhphC............sssCpstsh......ph.sCs..tssshhtp.spt	...........................MKl......llll.lhhhhshh.........................ssspa......................lshp.sap...sspCs....................................sss.GhG..............ash...............hsp.Chsht................................h.hhtss.sssshh.php.hs............sCp.....ss.hss..psap....hspChp......................................................sst...........hhhhh.s.ss...ps.h......Pssoh....lhsha...............................................ss....................pCsss..................thhhhpahsssps.ht............ss.s.p.hhCss...s..sh..hs..........sssCps.sh........h.pCt............................................................	0	98	133	133
+11746	PF11913	DUF3431		Protein of unknown function (DUF3431)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1346 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 291 to 390 amino acids in length. This protein has a conserved NLRC sequence motif.	33.10	33.10	33.30	33.20	32.70	32.80	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.70	0.70	-4.90	48	316	2009-06-19 16:41:07	2009-06-19 17:41:07	3	6	70	0	237	321	32	220.90	36	63.07	CHANGED	spslVlAphpsED.ssWlpp...l...s-....appsIYsVD...........cs..sush........psPtNKG+EuM...........sYLoYIIDaY-pLPss.hlFlHup+....hsWHNDs..saDssshl+pLphs.hVpppGYsNLRC.....pasPG.CPspl+...Php.....t.s.........ppsscthhsp......uappLFssss.................................VPcslussCCuQFAVSR-plpcRP+p-YlcaRp.......Wllc.......................TcLsDpl.SGRVhEYlWHllF........utps..........laCPctppCYCcs	...............................s.tlVlAphpp-.s.ssWlpp...h.......s-.......aptsIYsVD.................ssps.h..........psPtNKG+EuM....................sYLoYI...IDpYDs....LPsh..hlFhHucc....................htWHNDs....thc.ss....hl..pp.Lphp..hlpc...pG.....YsN..LRC........pas.PG....C.P.spl+......Pht............t.t...........................pttpp.th...hsp..............satcLFssss.........................................................lPch.lussCCuQFAVoR-pl..pp+P+pcYhchRc........Wllc.......................TpLsDth....SGRlhEYhWHllF.................stps.................lhCPpt.t.CaCp.h......................	0	33	85	167
+11747	PF11914	DUF3432		Domain of unknown function (DUF3432)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1326 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with Pfam:PF00096. This domain has two conserved sequence motifs: YPSPV and PSP.	26.70	26.70	28.00	27.10	25.10	26.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.43	0.72	-11.15	0.72	-3.97	6	489	2009-09-10 16:59:27	2009-06-19 17:47:26	3	11	427	0	32	454	0	94.20	81	24.48	CHANGED	A-KAussSosSs.l....ouYsssssoSYPSPl.TSYPSPV.TSYSSPsuSsYPSPVHooFPSPSlATTYPSsosTFQTQVhTSFPoSsVTNsaSS.VoTuLSD	...............V.EKAAPVSTASP.l....PAYSSSVTTS.Y.PSS...I.ATTYPSPVRTsYS.SPAPSSYPSPAHTTFPSPSIATTYPSG..TATFQTQVATSFSSPGVTNNFSSQVTosLo...	0	2	4	10
+11748	PF11915	DUF3433		Protein of unknown function (DUF3433)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1502 (release 23.0)	Family	This is a family of functionally uncharacterised proteins. The family is found in eukaryotes, and represents the conserved central region of the member proteins.	20.40	20.40	20.90	20.80	19.00	20.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.05	0.72	-3.82	166	434	2009-09-14 14:57:32	2009-06-19 17:52:00	3	9	77	0	373	464	0	90.50	22	15.65	CHANGED	.pahhsalPsllushlthhapsl-hphptlpPahpL...pp.......susAppSlhls...Ysuphs.hhsshpAlp......pp.Hahlshsohssll.sh.hlsllsu.ul	..............................................h..ahhpalPsllushlthhaphl-hplphlpPahtL.upt..................sssAppolh..ls...Y..huths.hhsshpAlp......pt...Hahlshsshssll..s..hlsllsuu..................................................	1	57	180	310
+11749	PF11916	Vac14_Fig4_bd	DUF3434;	Vacuolar protein 14 C-terminal Fig4p binding	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1661 (release 23.0)	Domain	Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.	25.00	25.00	36.10	27.40	19.00	19.00	hmmbuild  --amino -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.02	0.71	-5.13	38	357	2009-06-19 16:55:15	2009-06-19 17:55:15	3	16	279	0	254	343	2	162.60	47	22.35	CHANGED	-cpLLcpRushIIRpLChhLss.........E+lY+sluplLpp........c...sDlpFsshMVpsLNslLlTusELtpLRppL+...t.t.pp....tshsLFssLapsWC+NsVuslSLCLLupsYEhAasllphhu.....-h.ElslshLlQlDpLVQLlESPlFshLRLQLLEPc+a....PaLhKsLYGLLMlLP.QSsAFphL+sRLpsVs	.....................................................ppLLEtRGshII..RpLChhLss.......EpIa+shuslLtp..............................-.pDlcFAShMVpsLNhlLlTusELh...........pLRppL+....................shpspp....upslFssLa+SWCHNsluslSLCLLs.QsYcpAhsllphhu.......-l..EloVshLhplD+L.....VQLlESPlFsh.................LRLQLL..-sp..p..h.........PaLhKsLYGLLMLLP..QSsAFthLppRLpsVs.................	0	94	148	215
+11750	PF11917	DUF3435		Protein of unknown function (DUF3435)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1788 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 435 to 791 amino acids in length. This family is related to Pfam:PF00589 suggesting it may be an integrase enzyme.	25.80	25.80	26.50	26.00	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.21	0.70	-5.75	20	446	2012-10-02 14:09:14	2009-06-19 17:59:53	3	11	52	0	340	472	0	248.00	16	52.15	CHANGED	lEDlhphh+shlsTsctpFhhGhpRlQLsLhhhLushTusRPsAlLp...........Lpa+DltloLh+sPcG.usshhhl-lpscasKpah.Gtpph....Ns...............FhlPElIa...-PoLlLsP+saLlulLFttpAFps......slsosccLhp.LpVsssptph.L.L+schhDhalFp+s.hpstthcI...spshohsshpshl+phGEIsGFppshpsYphRhGuuctlspSt.lo-upcNllhpH.AsscTF.caYhspplcpDhQulhpGhsspctlhRhssphSRolDsRRPpcLosppctslccpPclpchtccpccL+p..................paGpstcsptss......................hhpchp+tppclpssRpRhpcch++ch+ccFspcQsllDIERQLS..Gpslcp-.hppshppsphhPPpph+LlcpLhshP.upol--E..hpRRhpulcAVsth	....................................................................................................................................................................................................................................................................................................................t..hh............t.t..h......................l.....hc.ph...ph.lhp........t...........h..t.......t.s...s.....h..h.hp...h..h............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	20	91	252
+11751	PF11918	DUF3436		Domain of unknown function (DUF3436)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_18 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF03572. This domain has two conserved sequence motifs: DPRL and SYEP.	27.00	27.00	27.20	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.67	0.72	-3.73	47	2173	2009-06-19 17:05:20	2009-06-19 18:05:20	3	4	1540	0	25	2173	0	53.40	58	14.49	CHANGED	ApVLTAGVQoSLNDPRLhISYEPohlp.P.ttsPthssLo.EpLlAhLQpuI+a-l	.ApVLTuGVQoSLNDPRLhISYEPSsl.E.sP...p.Q.s.PsLosLTpEELLAhlQcsI+aEV....	0	1	3	10
+11752	PF11919	DUF3437		Domain of unknown function (DUF3437)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1910 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 142 to 163 amino acids in length.	21.20	21.20	21.50	23.10	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.99	0.72	-4.27	32	338	2009-09-17 10:53:11	2009-06-19 18:08:46	3	8	258	4	240	340	5	89.90	40	5.22	CHANGED	pphhphHuulLGLuAlVtAFPYtsP.................WlPphLsp.Luphup.c.ss.ltpos+cslu-FK+s+...pDoW.phcpptFoc-..pl-sLc.sl.............lh.oYas	..........t..lhp+HuuVLGLuAhl.uhPYssPs................WhPplLhp.Lus+s......s..D...P........s....sltpolKcslu-F++TH.pDsW...p.cpptFTp-..QLpsLp.sl....l.ssYaA.......................	0	75	131	205
+11753	PF11920	DUF3438		Protein of unknown function (DUF3438)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1942 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 276 to 307 amino acids in length.	25.00	25.00	25.30	25.20	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.84	0.70	-5.56	25	270	2009-06-19 17:10:54	2009-06-19 18:10:54	3	3	195	0	68	269	20	253.70	42	93.79	CHANGED	h+hhlhhhslhhshsss.ApAsElh+WERlPLslPLpVGpERlVFlD+NVRVGhPss..lsu+LRVQSsGGAlYL+AsEshssTRLQLQDscoGElILLDIsApsttsspsshEPVRIVhusssss.p.t..........sssussusssuss......ts.pts+hpsPlPVVLTRYAAQsLYAPLRTVEPVsGIppVsl+hshcLoTLh..PohPVcAssLuuWpL-shhVTAl+LpNpuspplsLDPRtLQGpFluATFQHshLGPtGsscDTTsLYLVTcG+uhspALlP.pht.hc..........shstp..................sspp	.........................................................hh.....hhhh.hhh.hhs.hu.pA....sElh+WERhPLslsLpVsQERlVFlD+...NV.RVGhPss..Ls..s+.L.R.lQSs.G.GAlYLpAppsh..sTRLpLQsspsG-lILLDlsApt....spt.hE.PV+lV.sspsss...t...............ttttttt.st..t.............t..ps..sphpsPlPVsLTRYAAQpLYAPLRTVEPlsGltpVslchshslsTLh......PshPlpussLuuWp....lsshhVTAl+LpNpu.uptlsL...........D.PRtLp....G....pFhsATFQHth..LGstGs.spDTTslYLVTcG+s.spuhls.t...................h.............................	0	8	32	55
+11754	PF11921	DUF3439		Domain of unknown function (DUF3439)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1105 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with Pfam:PF01462, Pfam:PF00560.	27.10	27.10	27.10	27.10	27.00	26.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.87	0.71	-4.36	20	546	2009-06-19 17:20:45	2009-06-19 18:20:45	3	27	7	32	0	565	0	67.30	55	33.02	CHANGED	oCPGIcYLScWIpKNSull..h.ts.s..ssPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVPPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL	......uCsDIhYLScWIupHsGlV...hp.t...s..sh....ssPDSA+CSGTNTPVRAVh........ps....oh..............................................................................s..............	0	0	0	0
+11755	PF11922	DUF3440		Domain of unknown function (DUF3440)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1674 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 53 to 190 amino acids in length. This domain is found associated with Pfam:PF01507. This domain has a conserved KND sequence motif.	25.00	25.00	34.30	26.10	24.30	21.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.13	0.71	-4.72	18	1399	2009-06-19 17:24:49	2009-06-19 18:24:49	3	7	655	0	74	628	8	100.50	38	40.47	CHANGED	GVslppMRVspPFtsptpcuLpLY+lIEP-TWu+hluRVsGsNFuulYGsopu..hGa+s.lpLPcua.TW+pYshFLLcTL...Pcph+ppYhcKlpl.lpaW+p+.G...GsLs-...................................ch.cDl.tl.phR-lPSaKRhChsILKNDahC+hhuFu.TKp-ttc+	.............h..t..RlspPa...t.psL..ht.l-sthW.thhtRVtGs..sshYstp......huh.t...h.hP.th.sWppa..hLLpsh...s..h.tt..Y.p+hth.htaatpp.......h.......................................................sa+thshsl.ppDh.hp.htas.sp..........................................	0	15	36	47
+11756	PF11923	DUF3441		Domain of unknown function (DUF3441)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1795 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in archaea and eukaryotes. This domain is typically between 104 to 119 amino acids in length. This domain is found associated with Pfam:PF05833, Pfam:PF05670. This domain has two conserved residues (P and G) that may be functionally important.	26.30	26.30	28.40	26.80	26.10	25.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.55	0.71	-4.49	39	309	2009-06-19 17:27:43	2009-06-19 18:27:43	3	16	254	0	231	326	2	108.90	35	11.46	CHANGED	p.stsppstsphhphlspLsupPpssD.plhtslPVsAPasAlp..caKYKlKlpPGss.KKGKuspphlphF....................................hpstp.....................hspEtcll+sl+...sp-lstsls.ucl+....lshs	.........................t....tttttpphshlssLsGpPhspD.plLhAlPVCAPasulp..pYKYKVKLpP.G.ss.KKGK..A...sKpslshF................................................hpspc..................h.ss+Ep-Ll+ul+...-p-lhpsls.GKVKlsh....................	0	87	138	194
+11757	PF11924	DUF3442		Protein of unknown function (DUF3442)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_890 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 334 to 948 amino acids in length.	29.20	29.20	29.20	29.20	29.10	29.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.79	0.70	-4.82	50	2024	2009-09-11 14:47:36	2009-06-19 18:35:19	3	70	725	2	124	1347	552	264.00	39	30.81	CHANGED	phhspts..pphssthpsp.....ssptspphths............hhsspsssplpphL...sthups....plslshss.chphpssplshl.....hshh...-sspp.LhFsQhuhpp....p.sscsssNlGlGhRp...h.t...ssah.lGhNsFaDh...-hsps.ppR.hGlGuEh.apcahchsuNhYhslosh..+sstshp.thp......................E.RsA.sGaDlphphhLPthPp.....husplhappahGcp..VslFsp...sphppsPpuhshulsYsP.lPllolss....ph.ppupuspspsphs....lplsaphGt.shppQls.stls.......tcsl.tspRa.-hVcRsN	.......................................................................................................................hAp.u..tshGphhtsp......su-tA+shthG...........hsospsspplpsWL....utaGsA..........pVsLplsp..phphcs.S.ph-hh.......hPhh...Dspp......LhFo..Qhuhpp.....p.DcRhhuNlGlG.Ra..h.t.......ssWh.lGhNsFhDp...............Dhsps..ppR...hGlGuEh..WpDYL+hSuNhY..h...houW...+cu.shc...ap....................................p..RsA.pGaDlcspuhL..Ps.aPp......Lu.uplhaEQ..YaGDp.....VsLFsp...............sshp....+....sP..tAlohGl....s....Y.......T.....P.lPLlTlss........pa..+pGpuupscsphu....lplsYphGp..PhpcQLcsppVs......t....tcoL..tGSRY.DhVpRNN...............................................................	0	27	46	86
+11758	PF11925	DUF3443		Protein of unknown function (DUF3443)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1634 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 400 to 434 amino acids in length. This protein has two conserved sequence motifs: NPV and DNNG.	25.00	25.00	25.60	28.20	23.20	24.60	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.10	0.70	-5.78	24	153	2009-06-19 17:37:27	2009-06-19 18:37:27	3	2	74	0	49	152	4	356.40	44	86.77	CHANGED	ssssssuNssslTVs.sussssh...NhPhVSVTlCsPG......o.o..pCpTlDsVLVDTGShGLRlhuoAl.sul.ssLPtpos......uuuslA.ECspFso.uaTWGsV+pADVplGuE.p.........AuslPlQlIuDss.ssslPs..sCsssGs..stsosssLGANGILGIGshstDC..GssCss...ss..hsusYYsCssu..soCsssplPlupQVsNPVstF.usDNNGVll.phPslu.ssGtsSsoGpLlFGIGTQsNNslsu..sshlsoss...sG..hos.sapGp....shss..FhDS...GSNuhFFs.ssulss.....Cu...s.ssa..YCP....soshsloAolsussG.s.ousssFslu.NAssLhuss..shAassLuGs.h....s.sshaDhGLPFFY.........GRsVYhulcpss.ssG......sGP.alAF	.......................s.sssuuNshslTVs...sGssssh.....NhPhlSVTlCsPG.........T.o........pCQTIsNVhVDTGShGLRllsoAl.uul..uLPssss........uGusls.ECutFso.ua..TWGsVRpADVpIuGE.h..........AuslPlQlIuD.u....osssPs.........sCosuuu..shsTsusLG.ANG........ILGIGsh.shDC..GssCss.........os....h.usYYuCssu.....soCss..TosPluQ...QVsNPVstF.AsDNNGVIl.phPslu.ssGuu.SAoGoLlFGIsTQuNNsLsu..ssll..soso...sGs....lou.shpGp.....shss.......s....FhDoGSNuhFFs..su...u...hst..............Cu....stuaYCP....uSopohouTlsutNG.u.ssssohslu.sussLFush..shAhssLuGsh......s.ssh....hDhGLPFFa.........GRslYhuh-tsu.suG......suP.YhAF........	0	6	21	32
+11759	PF11926	DUF3444		Domain of unknown function (DUF3444)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1267 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 210 amino acids in length. This domain is found associated with Pfam:PF00226. This domain has two conserved sequence motifs: FSH and FSH.	26.10	26.10	28.70	28.70	25.40	24.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.60	0.70	-5.13	29	318	2009-06-19 17:39:28	2009-06-19 18:39:28	3	14	19	0	231	311	0	192.20	32	39.01	CHANGED	ppssssssphssPDs-FaDF-c.RsppsFtssQIWA.lY.DspDGMPRhYAhIc+Vhss.sF......+L+loWL-sps..psE......pWhstshshu.CGcF+l..upspthcshshFSH.h..hshcpsp+sthpIaP+KGElWAla+sWs.sWsss...t.scphacY-hVElLs.sassp.tGlsVs.LsK........lcGFpolFppptpps.....hhhIPpcEh.hRFSHplPua+hoGcEtp	..............................tt........hshs-s-FasF-ppRs..ppFtssQlWA.hY..D.s.DsMPRhYuhIp+Vhs.....sF.................clploaLcsps..psc....h..........pW.hpp.shshu.CGpFch....sp.p.p.........h.ps.hs...h.FSH.l...............thpts..t............p............t............h............hpIa............P++G-lWAl....Y..+s........Ws...p.Wstp.......s.....phhhcY-hVElls.saspp...tGlpVs.LhK.............................lp.Ga..tolFppt.ptt............hhhIsppEh.hRFSHplPuaphotpc..t............	0	30	117	172
+11760	PF11927	DUF3445		Protein of unknown function (DUF3445)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_501 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 264 to 418 amino acids in length. This protein has a conserved RLP sequence motif. This protein has two completely conserved R residues that may be functionally important.	25.00	25.00	28.70	28.40	22.90	24.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.64	0.70	-4.99	75	510	2009-06-19 17:41:17	2009-06-19 18:41:17	3	8	251	0	334	538	505	230.50	26	64.60	CHANGED	hulps.....hc..h.ppWlcl....D.ppYhsphsp+pclLpc.cscpshsh..........................PcupsAshELh-hlhp.aLsp+YP.phFph.......ptss.............hpNphsGpphshshs.........................s......................P.....Lphluc.lpEDhsllhpc.................................sspahLpAuslsFsus.WslspKlGhs......LstIH..sPVPtYc..pclppuh..................p+aFp+lpsscPlpRhNWslps...cs.pLhhss.......tphtphs.t..........ttptpssscphalRsERQoLpRLPcSsAllFoI+TYhhsls-...lpp	...............................................................ul..ht....pphlpl...D.ppYhppht.+tplltp.csppshth....................................Ppsh.A..shEl.hchl...........hp..aLst+YP.ph.Fph.............pts.s.......................hpNphhupp.hshs.t..........................................p...............................................P.......Lphluc.lp-Dhsllhpp...........................................sspahltAuslshsus.Wshpp+hGhs......ltpIH..sPV.Ptac..pplttu..h..................p+Fh.p+lps...sp.slpRhN.....Wslps.................ss..pLhhs...................tthtp.s..................p.ptp.shpphalRsEhQoLhRL.Pp...SsAllFsl+sahhslpcl......................................	0	69	177	275
+11761	PF11928	DUF3446		Domain of unknown function (DUF3446)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_833 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 80 to 99 amino acids in length. This domain is found associated with Pfam:PF00096. This domain has a single completely conserved residue P that may be functionally important.	25.00	25.00	28.80	28.10	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.15	0.72	-3.79	13	977	2009-06-19 17:42:26	2009-06-19 18:42:26	3	16	615	0	79	862	0	79.10	48	22.95	CHANGED	G+Fol-Pss..ssusShW..sEsllSLVS.GllGhsssPuo................ossSSSS.......oSuSotSssL.......Ssolppopss..sIY.S...usPsYSossuDIas-	.........G+Fuh-ss......us..ohW...PEslhSLVS.GllGMsssPso.....................oosSSSS.........sSuSs.t.SssL.........SCo.sp.tS.-ss.....sIY..S....AsPsa...sss.suDIaPE......	0	3	10	30
+11762	PF11929	DUF3447		Domain of unknown function (DUF3447)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_10 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length.  This domain is found associated with Pfam:PF00023. This domain has a conserved SHN sequence motif. It seems likely that this region represents divergent Ankyrin repeats.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.96	0.72	-4.17	607	1243	2012-10-02 12:10:21	2009-06-19 18:47:56	3	305	1	0	1242	1262	1	73.30	47	16.44	CHANGED	Fs.s.c.....IT.p.pCL.phSFLGGNs-IhsECL.K.....h..p..cPs....p.......pC.McaAI.lSHNIDF.VoF..L........hN..E..Y....sl.....c...I.s..........lp....Cs...h......apNLc.....uF....llY	.....................ap.scIT.ppCL.phSFLGGN.-IhsECL.K..............h.p....cPs.........p..pC.McYAIISH.NIDF.VoF..L........................hN.E........Y...sl.........c....I..s........................Lp...........Ct...t.apNLc.uFlla................................................	0	1242	1242	1242
+11764	PF11931	DUF3449		Domain of unknown function (DUF3449)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_769 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 181 to 207 amino acids in length. This domain has two conserved sequence motifs: PIP and CEICG. The domain carries a zinc-finger domain of the C2H2-type.	49.60	49.60	73.20	72.20	44.10	43.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.47	0.71	-4.80	37	347	2012-10-03 11:22:52	2009-06-19 18:56:47	3	14	298	1	237	326	6	185.00	48	37.88	CHANGED	uhtEatlpphsphLspphppThpplcRKpuhTtcEppt.................................................tt..spssppss............................pscsc.p-p-p.laNP.hpLPLGaDGKPIPaWLYKLHGLshpapCEICGNhsYhGR+AF-+HFsEhRHsaGh+CLGIs..sottF+pITpIc-AhpLac+lp.............ppppppph..........csppt..EhEDscGNVhscKsYpDLK..+QGL	........................................................................................................................u..hEhplhc.hschLs.cphptT+pNVpRKQuhTtcERpt.........................................................................pp.pppts.............................pscs-..--..--chlYNP.hpLPLGWDGKPIPYWLYKLHGLslpasCEICGNasYhGp+AFc+HFs.........EhRHsaGhRCLGIP.....NTspFtsITpI--Al.p.LWcKlc...............pppppp..ch...............ps-p-..EhEDupGNVhscKsYpDLp+QGL...........	0	83	133	197
+11765	PF11932	DUF3450		Protein of unknown function (DUF3450)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_773 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 260 amino acids in length.	26.90	26.90	26.90	26.90	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.38	0.70	-5.11	59	359	2009-06-22 08:13:35	2009-06-22 09:13:35	3	6	256	0	117	325	524	242.50	31	91.02	CHANGED	hphsh...........sll....sshhhssus.sst.........................sssls..pshpttsptspsutpSQp+I-phs-pspshht-hcpltccl-sLcl...YssplpchlssQppclsuLpppIsplpphcptlsPLMhcMl-sL-pFlphDlPFht-...cRtpRl.ppLcshMscu-losu...EKaR+lLEAYQIEh-YGpplpsYpupl.sl..sGpphpV-hL+lGRluLlhpohDuppshhWsspsp....pWps.Lss.phtsslscAlclAccQtsssLlpLPl..................ssE	............................................................hhh......hhhhhhsss...sst........................As..sLs..psp.shpsp.tspuu.sp.SQp.+IDphs-pstphhsEhcplpcElcsLpl....Y.pspLpp..hVs..sQpp-hsuL.......ppQlpplcpocpslVPLM.hcMl-u.L.cpaVt.Dh.Phphp.......pR....ppRl....pcL.cphhscADVosu...EKaR+l.LEAYpIEh-YGpplssYpupl.sl....supplpsDhLpLGRluLlhpohDupphhhWssppp......tWpt..lss...s.tpslspuhplApcQhsPsLlpLPl......t..................................................................................................	0	40	72	94
+11766	PF11933	DUF3451		Domain of unknown function (DUF3451)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_877 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 199 to 238 amino acids in length. This domain is found associated with Pfam:PF06512, Pfam:PF00520. This domain has a conserved ADD sequence motif.	27.50	27.50	27.80	27.80	27.30	26.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.66	0.70	-4.55	27	544	2009-06-22 08:19:43	2009-06-22 09:19:43	3	20	95	0	211	695	0	216.20	37	12.31	CHANGED	SchSphS.cshpppc..............ptppcppccchp.tpEcscs-ph.+pcspss.pp.t...........ph.++h.......pps.LSlsGSsFssRRsS+u.SlFo..hR....sRt+psGs-s..................-aADDEpSsst.....S-p+........GulhlPhh...p+poutsShs.....S+uS+l....hsspG.....chh.u.sh-sNGhsshhttsthhs.......s.tphlPt...t.......sshp-sphpp....p.psh.hs..shlpp..sttc..p.pshstssh	................................................................S-hScLSSKSsKEcR....................st.pc..c.++.p+c.ptt.pEc.t.-s.-.c.h.K.S-S..--uh++psah...........................................p.sht++hs......................pQo.LSl.....GS....F..ss...R.RsS+s.SlFS...FR.....GRs+DlGSEs......................................-FADDEaSsht..........-sEuR.......RsSLFlPhth.tcRRsSp.....S.s.........S+uS.+hh..........hshsG......Khp....S.sVDCNG.VVSLlsussshs....................ssupLLPt..............................ssos-sph+p....h.sshtho.h-hhpc...ttRp.pshp....h................................................................................	0	15	25	102
+11767	PF11934	DUF3452		Domain of unknown function (DUF3452)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1048 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with Pfam:PF01858, Pfam:PF01857. This domain has a single completely conserved residue W that may be functionally important.	26.30	26.30	26.30	26.40	24.90	26.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.69	0.71	-4.85	35	334	2009-06-22 08:24:09	2009-06-22 09:24:09	3	6	142	2	170	321	0	135.60	30	14.91	CHANGED	.stssh..........t..ttss......loLoplL+us..+lslhcFFcclppas.chssl.sshass................plccLcpsashhtsLh++acchapplFhss.............stp..p.............psssphscla+FuWlLFLhh+sc.shphhcDLVsshpLLlClLslllhp	...................................................ttsss.......t..psss...loLTclL+ss..clS............lhpF.Fpc.h+ca....chssls.phhpp..............................................................phccLc+sasV.slla+.Kac..hFpc...lFtss.......................................pp..........................hptssssp.clacFsWhLFlhsKup..hh.htcDLV..sS...apLLLCsL-llhtp..........................	0	42	67	113
+11768	PF11935	DUF3453		Domain of unknown function (DUF3453)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1335 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 239 to 261 amino acids in length.	25.00	25.00	28.40	26.70	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.46	0.70	-4.96	30	316	2009-09-16 16:45:01	2009-06-22 09:26:07	3	9	245	7	222	311	2	219.90	24	24.22	CHANGED	Lhcsp..DssVhKplI.sssslYtllhcal........hssssspphWsphstlKspIlsh.acos.hP......................GlKlsslKFlpplllsQopsss.st...........p.t.ps-hSLupVPssHsllphp.sLEtEuppLL-.tLLshhtpss.....................hsusllsAslNs...............................Luhlh+pRPph...ss+llsulhsass.sh......tss..h+lph+sV-+sl+hhlhphLK.pphs...phsuplpphls...chupshtclscps.p..cpsh..sccspcshc	.........................................................pp..sstVhKpsI.shsplY.hshphh.....................ss.tpthWphhsthKspIlph...hcss.ss......................Gl+hpslKFlptllls.o.tssss............................p.pp-hSLs.hlP....t.s.H..shlpht.tLptEup...t.hL-..hLLphhhpss.........................hsuh.lhsslss..........................................................................Luhlh+pRP.h...hs.cllp.ul.shpssh..........ss..t+splpSlc+sh+hhlhpllK....psss..........hpspl..pphlt.............clutstt-..lhcph.p...tpth...tp......p..........................................	0	68	123	184
+11769	PF11936	DUF3454		Domain of unknown function (DUF3454)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1847 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 60 amino acids in length. This domain is found associated with Pfam:PF00066, Pfam:PF00008, Pfam:PF06816, Pfam:PF07684, Pfam:PF00023.	29.10	29.10	30.00	30.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.79	0.72	-3.77	19	235	2009-06-22 08:32:58	2009-06-22 09:32:58	3	173	80	0	93	184	0	64.00	58	3.08	CHANGED	sppa.TPPSQH..ss..ut.-sT...PsH.lp.....VP-.HPaLTPSPESPDpWSSSSPHS.hSDWSEGloSPss	....................stpa.TPPSQH.....uuuh....-sT........PsH..p.lp..........lss.HPYLTPSPESPDpWSSSSPHS.sSDWS..-us.oSPs..	0	12	21	51
+11770	PF11937	DUF3455		Protein of unknown function (DUF3455)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1386 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.	25.00	25.00	27.70	25.20	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.63	0.71	-4.36	40	358	2009-06-22 12:19:23	2009-06-22 13:19:23	3	4	227	0	214	360	21	143.70	28	72.58	CHANGED	Puup.plthsshGcGsQsYpCps.....sssssh.............................shl..GshAs................................LaDs...uupt.....................................................................................lG+Ha....st....sP........sachp.....sG..SplsGpphu.........sAPsss.........uslsaLhLsupst........Gshssls.V.RlsTsGGsuPs..sCsst...spphpVpYsAcYhFas	.....................................t.phhh.shuhGhQsYpC.......stssth.............................hhh..us.As................................Lhct....s...............................................................................................lGpHa.........s....sP.............sachp.....ss......st..hhupths.........................sAPsss............sslsaLhLpsps.........Gshsslphl.Rl..sTtGGs.sPs.....sCsst......s....tthtV.YtApYhFa................................	0	52	118	175
+11771	PF11938	DUF3456		TLR4 regulator and MIR-interacting MSAP	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1799 (release 23.0)	Family	This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection [1]. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there [2][3]. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria.\	   This family has also been described as a SAP-like MIR-interacting protein family.	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.16	0.71	-4.22	23	696	2009-06-22 12:34:13	2009-06-22 13:34:13	3	19	141	0	392	667	1	101.80	23	50.13	CHANGED	ssKCpsC+hlssELc.ulscss.++c...l..tuh+lsscGcpcs+ph................ppSEhRLhEllEslC-+hp-Yslpp.csspp+hhhths.s.tphtt..s..th..............ss.sssLcttCcpllEcaE-plt-aatpcp.t..tslpchLCpcp......sptCp	....................s...Ct...sCph....ls.ph....t.thtph....t.pp...................thp.t.p.pt.th...................t.SEhclhEhh-t..lCp.p...............................................................................................................h.tCpthl.Ep..E-..l.phhhp.....tt.........pl.phlC.p........t.C................................	2	109	147	264
+11772	PF11939	DUF3457		Protein of unknown function (DUF3457)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1822 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 162 to 197 amino acids in length. This protein has a conserved CSL sequence motif.	25.00	25.00	25.20	26.50	21.70	24.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.77	0.71	-4.71	38	586	2009-06-22 12:36:17	2009-06-22 13:36:17	3	2	578	1	62	233	16	150.70	64	90.57	CHANGED	thsshsttLtusaccltpspM+-lPlhN.suLsVcAlGFp.........hap...G.ph......lGlllTPWFMNLVhlP.....s..sspsass.hssGs+tsls.hPuGsa-Flsuphs.......slGsapuCSLFSPMhcFssptsAhssAcAsLssLhs........Ptppss...................................................s.........st.hsR.RshLpGth.s	................Fp.TuPtApVQAAFEEIA+RSMHDLSFLH.PoMPVaVSDFT............................LFE.G.QW.......TGsVITPWMLSAVIFP..............G.PDQlWPh.RcVuEKlGLQ.LPYGTMTFTVGEL..-....................GVSQYLSCSLMSPLS+S.hShEEGpRLsDDCARMlLS.......LPVoNPD............................................................s..PcsuR.RALLFGRR.S.............	0	12	32	45
+11773	PF11940	DUF3458		Domain of unknown function (DUF3458)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_160 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 402 to 419 amino acids in length. This domain is found associated with Pfam:PF01433. This domain has a conserved FSAPV sequence motif.	20.90	20.90	20.90	20.90	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.24	0.70	-5.61	177	1678	2012-10-11 20:01:02	2009-06-22 13:40:18	3	12	1582	20	408	1377	673	363.90	42	42.45	CHANGED	sspp....asLslpQpsPsTssQ......s..p....KpPhhIPlsluLl.ss.s.G..pt....hshp..........................p.pVLplsp....scQoFsFp..sl...s.......pcPVsSL..LRsFSAPVpLch.shosc-LhaLhtaDoDsFsRW-AuQpLhtphlhphlsphp...........tt..t......lss.....t.hlsAhpslL...tc...ssl..DsAhhA.hLsL...Pocsplupth....p..ssDPsulatuRctlppplAptLpsphhtlYp..ph......tt..sap......sspshGpRuL+NhsLsaL....sttss.sts...phshpQapsA....s....NMTDphuALssLsps..p........sp..ppp.....tLssFhp+Wpc-sLVhDKWFulQAsssp..s.....ss...lppVcpLh.pHPsFshpNPNRlRuLlGuFu.sNsssFHstDGuGYpFlu-hllcLDshNPQlAARlh	...............................................p.sppYoLTlpQ...p........s...P...s.....T.....s.sQ......s.....-.........KpP...LHIPhsltLh.ss.c....G.cs...lsLphsG........................pssssV..LslTpuEQTF..sFc....sV.......h.........t..p...P.V.PSLLRpFSAPV+L-a.....c.aS-ppLsFLhpHspssFsRW-.AuQpLhsphl...ttslschp....................pG..ps..........lsl.ss..........c.lh-Ah+sVL...h.D........cpl......DPAhtAplL....oL....PSts.-lA-hh...............chlDP.AItpsR-sl..pcsLAs.pLt.--hhulYp.....st............t..ps..tYp...........s-ttshu+RsLRNssLpaL.......uh.s.-...........s..t..us.............s.LspcQacpA...........s.............NMTDplAALuAhlsu....p......hss......R-t....hhtcFpc+W+..pDuLVMDKWFhLQ.AosPs....s............s.s.....L-.pV+.tLh.pH..u.F..ohpN..PNR.................lRSLIGuFusuNPssFHAtDGSGYpFLs-hl...hcLsshNPQV...AuRLl...............................................................................................................................................	0	111	235	329
+11774	PF11941	DUF3459		Domain of unknown function (DUF3459)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_897 (release 23.0)	Domain	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 110 amino acids in length. This domain is found associated with Pfam:PF00128, Pfam:PF02922.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-10.14	0.72	-3.86	120	2445	2012-10-02 20:10:03	2009-06-22 13:42:40	3	16	1643	30	652	2023	110	89.70	22	15.94	CHANGED	haRpLLsLR+pc..PtLsss....phsssp.s.hhussslhspa+h.......sss.......tLt.lhhNLus...pssshs...........ssuclLausssstt..................sspLss.....tusshh	......................................YpcLlsLR+pp.......PhLs.tu............php.s..lt....s................s........s....s...s..h....l..hhhcch.............psp...............sLl.llsN...los.............pshshs.................tsstp.l..l...h.ss..ttst.....................shpL.s.hphhh.h...............................................	0	172	395	542
+11775	PF11942	Spt5_N		Spt5 transcription elongation factor, acidic N-terminal	Bateman A	anon	Bateman A	Domain	This is the very acidic N-terminal region of the early transcription elongation factor Spt5 [1]. The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4 [2].	24.20	24.20	24.30	24.20	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.89	0.72	-3.37	23	279	2009-06-22 13:40:14	2009-06-22 14:40:14	3	21	236	0	194	277	0	95.10	31	9.27	CHANGED	FlDhEAEVDD-E-E--.-p-t..s-..ptt.hhtph.............pcc+pp+ph-cccppppctssccls-hl.+..cRY.......tcp.....sstpstpsssshlspp...hLLP	..........Flt.EA-VDDE..-E-E-..-..E-.tsp-l..hp.t....tt..lcpst..............................................................hppD-pppR.chs..pphpp.pp.c.stEcluchh..+..c+Yucpp...........shttuust.usslsQp....hLLP....................	0	53	97	162
+11776	PF11943	DUF3460		Protein of unknown function (DUF3460)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2362 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 70 amino acids in length. This protein has a conserved WDK sequence motif.	25.00	25.00	52.00	51.90	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.00	0.72	-3.89	22	216	2009-06-22 14:40:06	2009-06-22 15:40:06	3	2	207	0	69	136	18	60.20	49	91.95	CHANGED	s.YpS-hTpFlspLKtc+PpLtpcQ+tGRALLWDK.slDh-tptchcsu+VsQ+PYVYpsp	....YpS-hTQFLspLKppKPpLEpcQpcGRuLLWDK..slDhE.Eppp.hptA+VsQ+PYVY.pp..	0	9	37	53
+11777	PF11944	DUF3461		Protein of unknown function (DUF3461)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2125 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length. This protein has two conserved sequence motifs: KFK and HLE.	25.00	25.00	58.30	50.50	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.65	0.71	-4.28	11	664	2009-06-22 14:41:40	2009-06-22 15:41:40	3	1	661	0	62	158	6	125.00	83	97.46	CHANGED	MYssLcolGIssscpIE+YTLRpEuspDILKIYa+KpKG..-hFuKSlKFKFPRQpKoVlsDuGu.psY+ploEIussLphll-ELDplsp..+p+p-sDlKpclLcDL+HLE+VVssKIsEIEccLEcL	..MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKG..EFFAKSVKFKYPRQRKTVVAD.GlG.QGYKEVQEISPNLRYlIDELDQICQ....RDRS.....EVDLKRKILDDLRHLESVVoNKISEIEADLEKL..	0	6	18	40
+11778	PF11945	WASH_WAHD	DUF3462;	WAHD domain of WASH complex	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2071 (release 23.0)	Domain	This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see Pfam:PF04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.	24.20	24.20	24.20	25.80	23.30	24.10	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.69	0.70	-5.12	6	199	2009-12-01 10:25:16	2009-06-22 15:43:54	3	8	109	0	106	172	0	237.80	44	56.81	CHANGED	EuQsYSVPlIpPDLRREEul+QlsDALQYLppVusDlFsRIspRVEcNRs+LQAIssRlplAQAKIcKI+GSKKAhKVFSSAKYPAsDcLQ-YsSlFsG.ss-shp.K+s+a+lQoKhhsLD-+ulQEKLpYasVplNs+pccc.....Dss-EGLGSLP.RNlsSVSSLLLFNTsENhYKKYVhLDPLAGsVTKT+sslEsEcEEKLhDAPloITpRpQLERpsAENYFYVPsLGpVPEIDVPshLPDLPGlADDLhYSADLGPGIAPSsPus..IP-LPohs..T-sl.-sutscppttt.sPP	...............................hh..t.t...sh.phhpsLt.Lpth.tplF..p.plptplcps+pplp........sIsp+lshAQAKl-.pl...pG.S..+K..AIpVFSuA....KY.P.A...s....cph..p.c..asul..F.........s...s...spc.....s...h...........p.p....s.........p.h.........c....l.......p...s.............c..t......p......hs.c..psl...p.Ecl...p.......ha.......Vpspp.p..p.t........sptccGLGsLP.ps.lsSloSLLLFNTsEN.h.Y...........cc.....Y.....s..h....l.D...sL...t.....u....s....hs.c..oc..hhlt....p...p..c.....c...cLh-APhSIs.+R.-pLcpps....s-s..Yh.Y..lPsLG..pV.P-I..D..VPshLP..DLPGIAsDL..hYs.s.Dh.s.....su..IAPSssss....lP-LPsht..sp.............................................................	0	41	51	78
+11779	PF11946	DUF3463		Domain of unknown function (DUF3463)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2277 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 140 amino acids in length. This domain is found associated with Pfam:PF04055. This domain has two conserved sequence motifs: CTPWG and PCYL, plus a highly conserved CxxCxxHC motif.	25.60	25.60	25.80	27.60	25.40	24.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.04	0.71	-4.58	67	326	2009-06-22 14:45:43	2009-06-22 15:45:43	3	8	316	0	145	297	55	138.20	51	37.89	CHANGED	hhlSPGYuYE+AP-..........Q-pFLsRpcT+pLFRplht....tspp++.....WpFNpSPLFLDFLtG...pp.sYcCTPWGsPohslFG.WQ+PCYLl.sE.GYspTFc.......ELMEpTcW-pYG....supsP+CusCMlHCGYEsTAVh-shtp.hphhcssht	.................hhlSPGYAYE+APD..........Q-HFLs.RccT+pLFRclFt....tGc.t.++.....Wp.FspSsLFLDFLsG....pp....sYcCTPWGsPshslFG.WQ+PCYLl...uE.GYspTF+.......ELMEsT-WDpYG....sGp..KCAsCMsHCGaEsTAVhcohspPhcshps...ht..........................	0	44	98	125
+11780	PF11947	DUF3464		Protein of unknown function (DUF3464)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2676 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 137 to 196 amino acids in length.	25.00	25.00	52.10	52.10	24.70	24.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.06	0.71	-4.76	29	127	2009-06-22 14:52:24	2009-06-22 15:52:24	3	4	99	0	66	129	115	147.80	32	82.77	CHANGED	.tss+pshsFc....Pcppppt.tt............................pstptptppppp........................tttt........psIPchVusRMhRRluhhoGlPohlGhusFlhuYhllspslh-.lPshlsllsShhhFhlGllGLSYGlLSASWDpp.sGSL...........LGhpphp.Nl...................sRhhpuh+stpp	.................................................................................................................tp........................t......................................tptp.ptttttt.........................................tpppptsIPpsVupRMh+RhuhhsGlPshlGhusFss.Yhlhsp.thh-.lPshsshhsShhhFGlGllGlSYGlLSASWD.pp.GSh...........LGhpEhptNh...................schhpuh+tt...........................	0	16	44	59
+11781	PF11948	DUF3465		Protein of unknown function (DUF3465)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2827 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 131 to 151 amino acids in length. This protein has a conserved HWTH sequence motif.	25.00	25.00	25.30	25.20	22.70	21.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.63	0.71	-4.33	31	258	2009-06-22 14:56:44	2009-06-22 15:56:44	3	2	187	0	36	166	4	137.10	50	92.21	CHANGED	hpthhhh.h...hslhss...................huhs......htus-s.............................tlppAFpscQSslQVpG..........pGsVh+lLPDDscGSR..HQ+FIL+L...so............GQTlLlA....HNIDLA..PRlssLphGDpVpFhGEY...........EWNs.KGGVlHWTH+DPp..s+H..sGWLKHsGphY..p	...........................................................................................................................ssss.............................sLpQAYps.....pQ.SDl..QVQG..........hGpVsKV..LP..DD.N-GS+..HQKFIL+L...sS...............GQTLLVA....HNIDLA........PRIPsLchGDpVEFYGEY...........EWNc.KG.GVlHWTH+..DPp..sRHs.cGWLKHNGplYp.............	0	10	25	32
+11782	PF11949	DUF3466		Protein of unknown function (DUF3466)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2541 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 564 to 612 amino acids in length.	25.00	25.00	25.60	26.10	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	599	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.22	0.70	-5.95	28	183	2009-06-22 14:58:19	2009-06-22 15:58:19	3	3	170	0	42	145	7	542.80	34	98.04	CHANGED	hspplpLsslulLsusu....ssusA.........slYcllpls..............shssshpss....YuhAlssssp....................................................hsssucs+hph..t.........csssGlsh...t--s.ash-.ppapY.......hpshstsph..sasssps.aAph........................t.sWhs.h..pslssssssss...ssh..sps...................hsohsshlpul..sssGht..VGstosstp................t..h.hpsFppRuhspstst.........lsP...............sptspsGuassshs......hNG..s..lsVG.sSpshusss.....sp............hptsh.s.......ts.s...sh..............................sh......ap.s+AhlW.hDsss.............lsp...pph.shs.psssDssh..hhpupuhulsssG.........hshGsuassh.sscssh.......hpsulahspp..sps.sht.....sWssp..............DpshpsShAsDINcN.....................sllVGpt+p.......sGshss+hFhhDss...sss..spal.........s.....ss.FasGu...uocstuINNpsplVGhl-spssp-.....+sRt+pGFlYshss................pp.hsh.sstsWhhc..-lpsu.s........sshspssca+IlpAssINDsGsIsATAhhppsu......Yc...spup.sh..........susGt..s.phsVsVKLhPhsu....us.pss.lpscss-s.pshERp........GAu.hu..WhsLhsLs.Llhh......RR+	.......................................h.shphpllAhulLlusp......sAsA.........AlYpVhEls..................ssstshtss.......aGlAIpssss...............................hshsucs+hphsss.........css-GlsY..........p-Es.s.F.uh-..psasYs....-....hpsacpYChsph..hY..o..o..Cps...WAssph..........................s.tWps.......-.lsuspsssu....hAa...lts.........t.ssh........spStssllNul...sssups.......lG.pststphs........................t.hh.spshptR...ps........lsP.............t.spsl.stuWp...........ssu..s..hsVGShSps.sssp.....u....................................................................................sh.........ato+sslW.hsusu................ssp......hsh..stu.s..s.scs.sp.....hhpuSht..s..lspsG........splhuVGYsoa..ssssph.......hpAul.F.hss......sss.s.ts........sWssp.l...sshp.p.ss....DhhaoNSlsoDlNcN.....................hlslGsAK+tt.............sGus..sN+hFlh-ss.....oss....usal.........o..........sslFFoGu.....uucusuINshNplVGpl..Dssss+E.....tGKPRRKRGFIYshusst..............................ss.u+..hthhss+uWhLD..DLT.sss........sssssNspaRIl-AoDINDu.....GlIuATAh+sssu.......Y-..osupsuh.........................sussp....-plVAVKLhPIss......us..sss.Ip....p+....us-p..pssERp........Guu...hGhhhLhsLu.l.l.GF.....RR+.............................................	0	8	18	30
+11783	PF11950	DUF3467		Protein of unknown function (DUF3467)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2299 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and viruses. Proteins in this family are typically between 101 to 118 amino acids in length.	25.00	25.00	25.50	26.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.17	0.72	-3.97	52	326	2009-06-22 14:59:57	2009-06-22 15:59:57	3	3	305	0	126	294	210	88.80	37	81.29	CHANGED	Mppppttt...........................................p.....lplc.lsp.......pshpus.....................YuNhshlsp.SspEFhlsF....ht....hh.ssts.psc..........lpsR.....llloPppAK+LhpsLpcslpca....EptaG.......................................................................................pIct	.....................................p.................................................ptp....lp.I-..Lsc...........-sApGs.....................YuNlAlIsH.SsoE.FllDF...............lp.......hh.PGhP..cup..............VpSR.....llloPpHAKRLlpALp-Nlt+YEptaG.Ip........................	0	59	106	118
+11784	PF11951	Fungal_trans_2	DUF3468;	Fungal specific transcription factor domain	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2291 (release 23.0)	Family	This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with Pfam:PF00172.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.30	0.70	-5.86	90	3818	2012-10-01 23:57:08	2009-06-22 16:07:12	3	72	166	0	3117	4021	1	286.50	11	52.41	CHANGED	hll.paa...hsplss..hhsshsps................tssatphllshuhpst.................slhpulluhuuhah.......................pth...p........pppthpattp..ulptlppslpphpppts.........................pphlss....l...Lhlshh................-.....lspus....tt....Wth.HLpssppllpphtt...........................t.ptsp..............thpahhphhsah-llushsts...........................................................................ptshhshpthpphhps...........................st.t...........hc....hhGhsss......lhhl.....luclspLspptcptptp...............................................phtppspplppplp.php.p.sshptthssttthtpht...................................hph.aphushlYlh..phl.................hshsss.........................s.plpphlpplhphlptls....sssh............tsLh...a.........PlFlsG...spshss................ppRphh..........pph.hppht....pph.....ushppshpl..lpclWcppc..................................st............................phc..W..hclh..............c................................................hshslhlh	...............................................................................................................................................................................................................a........h.......................................p...h.t..t.h.h..........h.shpp...........................................................................hlhp.u.ll..u.h..u..u..h..ah........................................................t.....t......................tttsh.pahtt.......u.l.ph.l.p.pt.l.t..p.ptt.p...................................................................tt.h....l.ss....h........hhL.hhh..................................................c...............hht.sp.....tp....................h.....H.h.pu..s...h.tllp...h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h......................................................................................................................................................................................................................................................................	1	361	1347	2518
+11785	PF11952	DUF3469		Protein of unknown function (DUF3469)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2159 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 108 to 439 amino acids in length.	27.60	27.60	28.00	28.50	26.30	27.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.77	0.72	-4.29	18	183	2009-06-22 15:08:59	2009-06-22 16:08:59	3	7	89	0	117	169	0	88.40	34	28.79	CHANGED	l-shRshhEo-cpWphR+cFlhpphssa........................thDcLlsLuhlauNhsFLGC+Ysp.clh-+lhcMAEGIsltcs.ppp...pRsplhtppp	....................l-phRs.tEo-cpWchR+cFlL+phsca......................t.ph..-pLluLShlWuNtlFLGC..pYsp.clh-KlhpMu-GItlpptsphp...pRs.l.tp..t.....................	0	33	45	80
+11786	PF11953	DUF3470		Domain of unknown function (DUF3470)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2503 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00037. This domain has a single completely conserved residue N that may be functionally important.	23.20	22.70	23.20	22.70	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.01	0.72	-4.36	133	1106	2009-09-16 09:23:58	2009-06-22 16:12:12	3	11	970	39	322	784	1301	43.00	43	39.76	CHANGED	ppp...alcLNu-LAc..tWP....sITp+K..-shsDA-cWc.....shpsKlp.h.Lpc	............ppalcLNAELAc..tWP....sITc+K..sshsDA--Wc.....GhtsKlp.h.Lpc........	0	86	190	252
+11787	PF11954	DUF3471		Domain of unknown function (DUF3471)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2961 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 98 to 114 amino acids in length. This domain is found associated with Pfam:PF00144.	26.60	26.60	26.60	26.60	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.28	0.72	-4.16	67	608	2009-09-14 14:36:04	2009-06-22 16:15:38	3	30	431	0	263	599	75	102.60	19	21.22	CHANGED	thpttttsshsstsLspYsGpYpps......h.........Gshslshcssp....Lhl.phssps.....t......hpL.hths..tspFhhchss...hp................hpFphs.ssGplsphshp.....ts..................hpshthtphs	...........t...t..tssssstsLpsYsGsYpps....h................h.......GslpV...p..t....c.s.sp.........Lhl.phssps....t............hpL.pa.hs...tcp.F.hhp..hss......hp.......................htFph..s..s.Gp.hsphphphs.............................t............................................	0	85	167	217
+11788	PF11955	PORR		Plant organelle RNA recognition domain	Moxon SJ, Barkan A, Coggill P	anon	Pfam-B_1780 (release 8.0)	Family	This family, which was previously known as DUF860, has been shown to be a component of group II intron ribonucleoprotein particles in maize chloroplasts. The domain is required for the splicing of the introns with which it associates, and promotes splicing in the context of a heterodimer with the RNase III-domain protein RNC1. All of the members are predicted to localise to mitochondria or chloroplasts [1]. It seems likely that most PORR proteins function in organellar RNA metabolism [2].	20.50	20.50	20.70	23.50	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.02	0.70	-5.69	27	336	2009-09-11 12:40:23	2009-06-23 17:10:07	3	12	23	0	211	323	0	298.50	30	73.17	CHANGED	hh+-.sLDph..lp+p+cl+hshpl+cllhupPs...ph...........lslptLsch.pcpLsl........+sh.sFlc+aPplFclah...........tspt.hthpLTststsLhpcEtplhpppp..sshss+LpKLLMhohs+.plsLcpltpl+t-LGLPcDFcssll.caPshF+lsp.......tsstphLELlsa...cssLAV..oslEctt..p................ttthppthsFs.lpaPpGaplp+phpptl.........pcaQchPYlSPYp...ssp.pls....sso..tchEKRsVuVlHElLSLTlEK+sphc+LscF+ccaslsp+hpchll+HPGIFYlStK...spppTVhLREAYccs.pLl-+..sPlhhh+-KhhcLhphsthtppt	..............................h+s.thDth..hppp+ph.phhhtlhphlhppss...th................hslp.ltph.tp.ltl......hthhtalc+aPplFphh..............tt..hhplTsphttLhtcEtthhpp.pp...s.hsp+LpKLLMhoh.s+.plslpplttl+h-..LGLPpDF.pss.ll.pa.Pph..Fplsp...........pttthLcLssa....sspLAl..oshEpttt..........................t..t.tthsFs...hphP.pGap.hpcphpph.l.........pcaQ.clPYhSPYp........csp...tlp.....so....tphEKRsVullHElLSLTlcK+h.hcplspF+cthsls...pp...hpphlh+.HPslFYlSh+......spppoVhLREuY..p........p.........s..p..Ll-p..sP..lhhh+c+hhpLht.sh....t.........................	1	21	125	171
+11789	PF11956	KCNQC3-Ank-G_bd		Ankyrin-G binding motif of KCNQ2-3	Cooper E, Coggill P	anon	Pfam-B_10256 (release 23.0)	Motif	Interactions with ankyrin-G are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system [1]. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 [2], that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3 [3]. KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2 [4]. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3) [5].	20.50	20.50	24.00	67.00	18.60	18.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.45	0.72	-3.96	4	127	2009-06-24 10:53:54	2009-06-24 11:53:54	3	9	37	0	50	111	0	100.90	62	12.78	CHANGED	s.pDpsushshpussR-SDTsLSl.SVsHEELERS.SGFSISQs+-sh.shGss..............Auuus..ps+sRP.alAEGEoDTDoD.aTPsGs..PlSuTG-G.hu-ssWsu	.............pDp.usR.pcushRDSDTslSl.SVsHEELERS.SGFSISQs+Esh...shss.s.................uusu...hschRP.YlAEGEoDTDoD.hTPsGs..PhSuTG-G.huDssWs....	1	2	6	19
+11790	PF11957	efThoc1		THO complex subunit 1 transcription elongation factor	Wood V, Coggill P	anon	Pfam-B_2059 (release 23.0)	Family	The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1 [1]. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm [2,3].	21.00	21.00	34.60	25.00	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.76	0.70	-6.00	21	319	2009-09-11 16:24:37	2009-06-24 18:08:11	3	16	247	0	226	332	6	432.10	28	70.86	CHANGED	tplhsLLDllhhhsc......pEp..spsuhlFa.Llc-llDh.TlssCcclFs.YlESRh-phpptphhp..+sh..............lLRpCN-LLRRLS+.....s.ccssFsGRlhlFLsphF....Plu-+SulNl+G-aps..ENlTsas.........................c.s.pppssssshclDhs..........................................................hYshFWuLQpaFssPspl...asst.phssFcpslcsslssFpphpp....-h.tp.ttptpt...-sptusc+ptss.-s..................p-hssu....FssKYLTuccL.....h-LplsDss.............FRRplLlQhLIhhpalhslsppppsp..............psh......hhLspccspahpphcptltphLppsh..p.......GthFhRhVcplLsp-csWlpWKsEGCP..shccs......hshtsh.ssccs......hpKhhhs...h............h.hGstsLshLhp.cspsulcpLKctpR.hpl......Pshcsahpslh-schchDhupsp....ppp.thcsctspsW+sLRlhu+ppLttFs+ls-s.pslcslh.........-t.sspcsshh.pshsp.ppcch	......................................................................................h.thlslh..hsp..................pt...spssh.ah..Llt-lh-s.s..lstCcplFs.alEpphph..hpt..p.hh...p..Kph.................................................lLRhCN..-...LLRR.LS+.............s..psslFCGRl.lFLuphF....PLu-+S.u............lNlp......upash...-NhThas...............................p.tptptsss..pth.lDhs................................................................................................................hY.hFWuLQchFpsPsph...apt...........patsF...t..pth..ptsLssFp..phph.........p..........................ptpt.pcch.tt..t.....................................................t..tsp........a.s.KaLTopcL............hcLp....Ls...Dss.............FRRplLlQhLIlhpaLhs.sphpptp....................................................hLsppp............ppah..pphpp.tl...hphLppss...c............GthFhchlcplLp.p-csWspW.....K.t-.u.Cs..shp+.............ts......t.s.ppt.................hpKhh.........t........................................h.hGs...pLspLhp....p.sp....s....hpthcs......pR....h................Psl.ppahpth.h-...phD.tp..........................cpphth.sp....tshsW+sLRhhu+p.....p..thF..p...h...s....p.....ptl....hh......t...............p.........................t................................................	1	81	129	187
+11791	PF11958	DUF3472		Domain of unknown function (DUF3472)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2598 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, eukaryotes and viruses. This domain is typically between 174 to 190 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.	25.00	25.00	26.50	25.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.28	0.71	-3.94	23	181	2009-06-24 17:14:14	2009-06-24 18:14:14	3	13	133	0	72	188	25	176.30	25	40.36	CHANGED	YhGhQssu.......pocRplL.FSVWustsocss..h..-.........upsshss..pFGsEGo.Gspsh.hsYPWpuGpsY+Fplpst....psGtohasuahpDss..s...p..cahhIAShphP+ssshlsssto...FlEsFs....scpGshsR.puaas.spauhstts.phhclhpsshosssssspt..phsa.suGsss.sthalpssGhh	.............................YhGhQsps............pspcplL...FSlWsshsssss.....h....h..........ussspss....pF.GsEGo..Ghpst.hsas.Wpsu.p.tY+hhlpst......tss....pTpa...ssahpDss..s............s..phphIuohchPpsssshstshu..FlEsas......ppGptt...R..tuhhp..stauh..shss.....ph.phpptp....hohs.ssp......pa.thuss..s....thhhhpssG..t.................................................	0	35	53	61
+11792	PF11959	DUF3473		Domain of unknown function (DUF3473)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3065 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 130 amino acids in length. This domain is found associated with Pfam:PF01522. This domain has two completely conserved residues (P and H) that may be functionally important.	29.60	29.60	30.30	31.30	26.20	29.30	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.83	0.71	-4.73	51	224	2009-06-24 17:18:14	2009-06-24 18:18:14	3	3	209	0	97	225	89	131.50	30	46.29	CHANGED	SSlaPlp.HD...hYG....hPcu.PRhP.aphsssst.....................lhEhPloThplh....stplPsuGGGaF..RlhPYs.....lh+hslpplNpps.pPslFYhHPWEl..DPsQPR....l..shshcs+FRHYhNLspsptRLcpLL.....p-Fcasphsplhtptt	............................SSl.Psh...s...pYG.....h.ps..PRhs.athtpt.........................lhElPsoss.hh.....hplPhuGGhah..RhhPht......lh+hhlppl.cp-.ts..hlhYFHPWEh....Dst.pP+......h...phshh..p..phRpassh.pphppRLcpLl.....psapasphpphh...th.........................................	0	34	79	92
+11793	PF11960	DUF3474		Domain of unknown function (DUF3474)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3095 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 126 to 140 amino acids in length. This domain is found associated with Pfam:PF00487.	27.80	27.80	27.80	27.80	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.02	0.71	-4.15	30	528	2009-09-16 09:00:21	2009-06-24 18:21:57	3	3	223	0	164	530	0	79.10	35	20.44	CHANGED	MAoWVLSEC.GL+PLP.+lY.s+PRsuh....tpssss..plRhhssspshs.s.th....hs.s..t.....RN....WuLpVSAPL.Rlsolsc--cc...................ppspcFDPGAPPPFpLADIRAAIPKHCWVKDPW+SMSYVVRDVAlVFGLAA	......................................................................th................................................................................................................................................s....P....t....s.P.PF.olu-I+sAIPtHCap+sshRShSYVl+Dlsls.....h........	0	36	99	143
+11794	PF11961	DUF3475		Domain of unknown function (DUF3475)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3098 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 60 amino acids in length.  This domain is found associated with Pfam:PF05003.	29.70	29.70	32.00	30.90	23.70	23.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.49	0.72	-4.14	20	207	2009-09-11 16:23:54	2009-06-24 18:24:45	3	4	18	0	134	194	0	55.90	43	11.06	CHANGED	ILAFEVAsshoKsssLhc.SLS-pslppL+ppsLpS-GVcpLVSsDpstLLpLusAEh	.....ILAFEVAsshsKsss.Lap.SLS-pplp+L.+pclLpS-GVppLl.....SsDps.LLpLAsA-h......	0	11	78	109
+11795	PF11962	Peptidase_G2	DUF3476;	Peptidase_G2, IMC autoproteolytic cleavage domain	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3119 (release 23.0)	Domain	This domain is found at the very C-terminus of bacteriophage parallel beta-helical tailspike proteins. It carries the enzymic residues that induce autoproteolytic cleavage to bring about maturation of the folding process of the helix in a chaperone-like manner. The domain thus mediates the assembly of a large tailspike protein and then releases itself after maturation. These C-terminal regions that autoproteolytically release themselves after maturation are exchangeable between functionally unrelated N-terminal proteins and have been identified in a number of bacteriophage tailspike proteins [1].	25.00	25.00	25.30	25.40	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.53	0.70	-5.24	19	176	2009-06-24 17:27:32	2009-06-24 18:27:32	3	11	141	9	16	159	78	206.70	42	34.28	CHANGED	ssstIhuStuspss..tsYslshGhGsssss..stslKhp.....uhsGslphsGslssuu..uDYAEhFEShsGpsIcs...GhlVTL-..G-KIRhAptuDp...hlGVlSpTuullhssushpWpsRYLpsEFGshlYcphp......D-........pus........hhchPh.NPcacPshc..YhsRpcRsEWslVGLlGQlhVRsDpTVpsG.chlp..ups.G......IuTpss..pG..hpVMclTssastp+GhulALs....hl+	....................usptIhup.u.pu-....puYShhhutGsspssp...shssKW.......upsGphhhsGAshsuS.hoDaAphFEohDsphI-s...GYhVThs...t-KIRhAsssDs...ILGls.....SuTsAlIusuuuhpWpcRYhpDpFGth.Y.psp.....................................up...........phtPllNs-aDPspc...YluRc-RsEWhsVGLIGQhhVRsDsTspst.sYhc..sss.G........IATKu-..sG..ahVhKhTut.......s.h.....h........................	0	7	9	10
+11796	PF11963	DUF3477		Protein of unknown function (DUF3477)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3147 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in viruses. Proteins in this family are typically between 246 to 7162 amino acids in length. This protein is found associated with Pfam:PF08716, Pfam:PF01661, Pfam:PF05409, Pfam:PF08717, Pfam:PF01831, Pfam:PF08715, Pfam:PF08710.	25.00	25.00	30.80	30.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.19	0.70	-5.46	4	151	2009-09-16 08:59:33	2009-06-24 18:29:47	3	10	56	0	0	167	0	295.00	47	7.14	CHANGED	MuKhuKYGLGFKWAPEFPWMLPsAuEKLuNPp+SEEDGhCPSsAQc.cstGhshsNHV+VDCpRL.u.ECCVQSulIRDIFVcEDPpcVEs.ThhALQ.GoAVLVKPshthSlpAhtsLGshPKshsMGLF+RhslCNTtcCssctHVAapLahlpPsGVChGsGcFlGWhVPlshhPpYu+pWlQPWslhLRKsGpKGuhsScHhRpuhphsVYDFsVEDAht.VHsEPKGKaSpKAYALl+sYRGlKPlLaVDQYGCDYoGsLAcsLpsYG.-hTLp-M+th.slWtssh-h-VsVAWHVsRDsRhsMRLQohATlpulsYVApPTEDlVDGsVVl+EPsHlLussuIlL+hPs	............................M.KhsKYGLth+WAPEF.Whh.sAtEcLssP.pS-.shhCsosuQt.cshGhs..NHVhlDCppl.t.EhpVQSslIR-Ihhppc...lEs.h..Alp.tpAlLlpssh.......hshGs.PpshsMGLF+ph........tsptaVsapL.hhpss.sshGt.pFlGWhlPhshhP..s+pah..h.hhlcctGpc.sh.ps+hhtshp..sYsFpVEDAh-.V.HDEPKGKaScKAYALl+sYRGlKPlLaVDQYGCDYoGsLAcsLpuYu..-hTLp-M+th.slWtpshsh-VsVAWHVsRDsRhVMRLQohATlpulsYVApPTEDlVDGsVVl+EPsHlLussuIlL+hPp.	0	0	0	0
+11797	PF11964	SpoIIAA-like	DUF3478;	SpoIIAA-like	Assefa S, Coggill PC, Bateman A, Eberhardt R	anon	PFAM-B_640 (release 23.0)	Family	These proteins adopt an alpha/beta SpoIIAA-like fold, similar to that found in STAT (Pfam:PF01740). They adopt open and closed conformations arising from different arrangements of their alpha-2 and alpha-3 helices. They may be membrane associated and may function as carriers of non-polar compounds [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.48	0.72	-3.76	151	602	2009-09-14 13:55:16	2009-06-24 18:34:40	3	3	394	6	265	584	59	107.30	20	83.94	CHANGED	sll.slphs..GcloppDhcp.lhstlcph.hp..ppsplplLh-hs.sh..puhsh.tAhhpph...h.....hp.phpc...hc+lAllussp.ahphhsphhsh.h.....hssph+hF..pppspAhsWLpp	.............................................hlshthp..Gcls.pp-hcp....hhsh.lctt.hp....ppsplp.lLhchs..ph....pGh..sh..sA..hhcsh.......pht.....hp..phpc....hc.+l....A.llu.ssp.Whphh.s..plhsh..h.......hstcl.+hF..scppcAhtWLp.t.....	0	106	181	232
+11798	PF11965	DUF3479		Domain of unknown function (DUF3479)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1065 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF02514.	27.30	27.30	27.80	30.40	26.90	27.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.66	0.71	-4.44	61	302	2009-06-24 17:37:06	2009-06-24 18:37:06	3	6	209	0	139	323	268	160.50	33	12.73	CHANGED	h+lVhloh-sphsuultpAstpLppc..hsuLclshasss-htcsstshpphppslspADllhuohlFhE-hlpslhstLpstp.pscshlsh.Shsplh+LT+lGpFsh....spspuuhhshlK+hts...pppusspspt.......phphlRplP+lLKalP.GKAQDlRsah	..................+lVhlsl-spapuulppAsp..pLspp...h.ul-lssahspEL...........ccstsh...pphpp-lspADlhluSLlFhE-hsp.hlhpslpspRpphcAhllF.ShPElM+LsKlGsFsM...........upspuuhsphhK+ht.......p.p..p...u..s.shtsu....................hlKlL+plP+lLKalP.sKAQDhRsah............	0	38	82	118
+11799	PF11966	SSURE		Fibronectin-binding repeat	Pallas J, Coggill P	anon	Pfam-B_5998 (release 23.0)	Repeat	Streptococcal surface repeat domain - SSURE - is a protein fragment found to bind to extracellular matrix protein fibronectin but not to collagen or submaxillary mucin in Streptococci. Anti-SSURE antibodies recognised the corresponding protein on the surface of streptococcal cells. The full-length proteins are thus fibronectin-binding surface adhesins.	25.00	25.00	29.60	47.50	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.76	0.72	-4.39	6	697	2009-06-24 17:48:00	2009-06-24 18:48:00	3	17	253	0	24	516	0	80.90	74	34.13	CHANGED	DNGsAKNPAL.PLcG..LTKGKYFYpVsLNGNTsGKcGQALLDQlRANGo+oYpATV+VYGs.KDGKsDhsNlVATKpVsIsIN	.......DNGsAKNPALsPLtp..hTKGpYFYpVsLsGNssGKpcQALIDQhRANGTQTYpATVpVYGN.KDGKsDLsNlVATKpVTININ.......	1	6	6	12
+11800	PF11967	RecO_N		Recombination protein O N terminal	Mian N, Bateman A	anon	COGs	Domain	Recombination protein O (RecO) is involved in DNA repair and Pfam:PF00470 pathway recombination.  This domain forms a beta barrel structure.	21.00	21.00	21.10	21.30	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.43	0.72	-4.12	154	4019	2012-10-03 20:18:03	2009-06-26 14:16:15	3	8	3998	7	873	2670	1561	78.10	27	31.53	CHANGED	M....h...pspulVL+spsasEsstllslhTccpG+lssls.+Gu.+p.+..S+htu.hhpPhshlchhht......tpps.Lts.lsps-hlpsh	......................ppculVL.+sp.sa..sEsshllslhTcctG+lphl.A.+Gu...+p..t+......Sphtu..hlQPFshlphphp.........t....p.....p.....s.lps.lpps-hlp............................	0	293	578	740
+11801	PF11968	DUF3321		Putative methyltransferase (DUF3321)	Wood V, Coggill P	anon	Pfam-B_6141 (release 23.0)	Family	This family is broadly conserved, being found in fungi, plants, arthropods and up to primates. it may be a methyltransferase.	19.80	19.80	19.80	20.20	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.65	0.70	-4.72	25	219	2012-10-10 17:06:42	2009-06-26 16:42:37	3	2	191	0	159	216	23	192.80	31	60.29	CHANGED	upIcucIcphGGL-uYQhASphGQspcRGGDSSKlLVcWLpsthhphctp..p...................................L+sLElGALSspNshSpsshFc.VsRIDLNS..QpsuIhcQDFM-RPLPps-sE+FclIShSLVLNFVPsstpRG-MLpRhspFL+ssp......................t..s.LFLVLPLPCVsNSRYhspppLppIMsSLGFthspp..+popKLhYaLach...........psp........hpspha+KcplpsGss+.NNFsI	...................................................................................................t.l.tthtt.GGhptYQ.uS...up..p+t...ou+hlhphlt.......................................................................lphL-lGults..............N.hs.p.......thhp.shtIDLps..pp.tlhppDFhc................p........P....l..............s........p......t....p...............s....-.......p.................FcllshSLVLNaVPsstpRGpMh++spchLp.suh................................LFll....lPts.....C.l..p..NSRahs......pphpthhpuLGaphhp...cpss+lh.ahhach..................t...................................................................................................	0	50	81	129
+11802	PF11969	DcpS_C		Scavenger mRNA decapping enzyme C-term binding	Moxon SJ	anon	Pfam-B_9894 (release 8.0)	Family	This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.73	0.71	-3.86	99	1192	2012-10-01 23:45:21	2009-06-26 17:03:18	3	21	724	20	661	5559	3144	113.70	25	50.60	CHANGED	phla...shlhptpp..sppl....la..cD........-thlshpDhp........Pp.........ushHhLsIP.++..................cIpolpD......L.....spc.chsLLtchhphupclhppph.t..............h.ps.hphshHhtP..ohaHlHlHllu......h.sptht	.............................................................hla.s.hl...ttp.........ssph......l.a..cD................-phlshp.Dlp......Pp.......................AshH..hLllP..+.c.........................................cIto.lp.c.......L....................st.c....c.h....s....L...L.t.c.h.h..p...h..u...p...c..l.h.p..p.p.h.t............................................s..p.p...h..ph....G.h....H....h.ts.............oh.h.H.LHlHllu..............t...............................................................................	0	218	363	534
+11803	PF11970	Git3_C		G protein-coupled glucose receptor regulating Gpa2 C-term	Wood V, Coggill P	anon	Pfam-B_11657 (release 23.0)	Domain	Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail [1]. This family is the conserved C-terminal domain of the member proteins.	21.00	21.00	21.00	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.48	0.72	-4.22	19	170	2012-10-03 04:04:29	2009-06-26 17:08:30	3	3	114	0	132	185	0	74.00	30	13.66	CHANGED	+cRRppIp+Qh+uIFIYPhuYlhlWlFPhlhcshpas.ap.......h..pptPhhWlshlushhpPhsshVDshVFhhRE...+PW+h	.........t..php+lpR.l+hhhlYPluYlllhL.Plsstthths.............p.spsPshhhhhluushhshsGhVDsllaslpc...+....h......................	0	28	68	110
+11804	PF11971	CAMSAP_CH		CAMSAP CH domain	Bateman A	anon	Bateman A	Domain	This domain is the N-terminal CH domain from the CAMSAP proteins.i	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.84	0.72	-4.33	27	382	2012-10-03 10:10:54	2009-06-26 17:12:11	3	57	114	0	173	3124	9	79.90	31	5.82	CHANGED	hspscpsshhs.lcslhcDhsDGssLstllHaYpPphlplcslshppshShtcslhNlpllpphspcpL..psh.h.sh-Dllhs.	...................stpssh..t.s.tV..psLs..p.shpDGshL.C.tLlpp...Y..pPp.hl.s...L.....c...-Is.........h..+sp.h.S............h..slp.Nlphh...s..hs.ppth..p...h.p..Dhh.h...................................................	1	40	54	97
+11805	PF11972	HTH_13		HTH DNA binding domain	Fenech M	anon	Pfam-B_8688 (release 14.0)	Domain	This is a helix-turn-helix DNA binding domain.	24.20	24.20	24.20	24.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.56	0.72	-4.12	12	171	2012-10-04 14:01:12	2009-06-26 17:21:52	3	4	128	0	53	149	5	53.90	53	15.22	CHANGED	LPpLl-LlloRPlVSuuMlscpLclTspuAlpLVpELGl...REhTGRGRaRAWGll	.........LPpLhELlLppPLVSuthltKcLpVT.puAh+...L...l...sE...LsL....RElTGRGRFRAWGll......	0	7	28	39
+11806	PF11973	NQRA_SLBB		NQRA C-terminal domain	Bateman A	anon	Pfam-B_3622 (release 8.0)	Domain	This family consists of the C-terminal domain of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins.  The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.20	0.72	-3.63	74	761	2012-10-03 10:59:06	2009-06-26 17:24:09	3	6	729	0	165	657	475	51.30	46	11.49	CHANGED	VlALuGPpVpp..PRLlRTplGAslspLssGc..lpss.psRlISGSVLsGcpstu	.....VlALAGPpVpp..PRLlRThlGAsLsp..Lss..u-....ltsu....-......sRlISGSVLoGppup.s.....	0	44	94	137
+11807	PF11974	MG1		Alpha-2-macroglobulin MG1 domain	Bateman A	anon	PDB_2a73	Domain	This is the N-terminal MG1 domain from alpha-2-macroglobulin [1].	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.78	0.72	-3.43	168	1084	2012-10-03 16:25:20	2009-06-26 17:28:18	3	42	1060	0	261	942	44	99.60	36	5.76	CHANGED	lsslu.lt.spps.....................phhlps.ss...upshss...pVpl......hs.pps.t.........sht..psp..os......spuhhph.........................................................lph....psshshs.......phslsupss	....................lSDlG.lo.s+ph........cspl.........clFspSLcs..Gts.sGl.cVpL..ls.cpGp.............sLs..pus..oDupG+lplcss.................................cssslllA+.....c...................csphohLcL....phsuLDLu...-FsluGt..s...................................................	0	75	154	208
+11808	PF11975	Glyco_hydro_4C		Family 4 glycosyl hydrolase C-terminal domain	Mian N, Bateman A	anon	IPR001088	Domain	\N	21.90	21.90	22.80	21.90	20.90	21.60	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.45	0.70	-4.57	8	2959	2012-10-02 13:39:36	2009-06-26 17:33:48	3	5	1463	33	464	1786	410	216.50	29	50.24	CHANGED	-clclphhGlNHhsWhpclphp.GsshhspLh-tluphucss.phcs..h.tssascshh+utsh.ths..hlssoatpahhhs...cahlchphssh...........hsRsppllcchpKplhpp...........htchhKppp.hlpspcl-c+.uuhhu-tthshl...aNsccthhhlNl.NsGtIsNlPssusVEVsClls+NGspP.hhlGsLPppltu.LhcpplsspchssEAhlTtchpplapAhhhsPpV	..............................................................................................plphchhGlNHhsahppl..hc..Gps.h....h.s.....p.......Lhc...tl....t...p............t...t........................h.........s..........c...........s............hh............t...s..........h..s.............p.....s..h..l.+.........h....t....................hlP.s..s..Y.h+Yahhs.............c...h..lp.....th..tc.h...............................hsRu.....ps...l.p.........chc+p.l.h.............................................ph..h..c.s.......p.....h..t...h...p....s..p...c..l.-..t.....+....s...us..h..Y...u.c...........s..shphl...................as.s.c.t..s..h.h.h.lNl.N......p............G..........t.......IsNlP...s-ssVElsClls.tsGspP..htlG.pl..Ps.t.htG....Lhps.hshEpLsl-Ah....lstshpcshpAhshsPhs.................................	0	162	297	368
+11809	PF11976	Rad60-SLD		Ubiquitin-2 like Rad60 SUMO-like	Wood V, Chahwan C, Coggill P	anon	Wood V, Chahwan C	Family	The small ubiquitin-related modifier SUMO-1 is a Ub/Ubl family member, and although SUMO-1 shares structural similarity to Ub, SUMO's cellular functions remain distinct insomuch as SUMO modification alters protein function through changes in activity, cellular localisation, or by protecting substrates from ubiquitination [1]. Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). Despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9)), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. Structural analysis of PDB:2uyz reveals a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating SUMOylation [2]. The Rad60 branch of this family is also known as RENi (Rad60-Esc2-Nip45), and biologically it should be two distinct families SUMO and RENi (Rad60-Esc2-Nip45).	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-4.29	42	1068	2012-10-03 10:59:06	2009-06-26 17:36:11	3	36	345	50	689	8130	273	69.50	32	32.96	CHANGED	lplhl+stssc..clthclctsoplpcLh.ptappcpslst.....pplcLlFDGcplpsspThp-hslcDsDh..l-lll	................................................................plpVt.s..p.-ss...pl.p.F..+.l...K..c....s....T......Lp...KLh...cu....Ys......c....+.....p...G...l..sh..................psl+Fh...F.D........G..p......p.l......s....t...s....p...T.P...ppL.-.ME.D.t.Dh..I-V...............................	1	230	363	528
+11810	PF11977	RNase_Zc3h12a		Zc3h12a-like Ribonuclease NYN domain	Bateman A	anon	[1]	Domain	This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes [1]. It has been suggested that this domain belongs to the PIN domain superfamily [1]. This domain has also been identified as part  of the NYN domain family [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.90	0.71	-4.39	28	659	2012-10-03 20:43:45	2009-06-29 14:20:43	3	19	191	6	414	616	25	146.30	36	23.62	CHANGED	phRhlVIDGSNV.Ah......sH......sppch......FSs+Glthslpa..FhpRGHcslslFlspa..phpt...................ssthp-pchLpcLhc....tshlshsP.....Spph.Gpp..saDDRaILchApcpcGllV.SNDpaRDlhp.......cpsch+chlcp..........................RlLhaoFs.........tDthh.ssD.PhGRpGssLpc	............................................................................s.h+.lVIDGSNV..Ah.................sH............Gppch.......................FSs.+.GItlAVpa...Fh.c..+....G..+.p.s...l..s..VFlPpa..Rpcp...........................................ss..hs-..pchLp...cLpc....ptl..Lsh...TP..........o+ps.G.pc..hs..s.aDD.Ral..l..clA..h.c..s..c............G..lIV.SNDpaRDhhs..........-pspa..+.....c.....hlcc...........................RLL.aoFs....................sshFM.PcD...PhGR.GPpLp.p..................................................................	1	101	165	282
+11811	PF11978	MVP_shoulder		Shoulder domain	Bateman A	anon	Bateman A	Domain	This domain is found in the Major Vault Protein and has been called the shoulder domain [1]. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.	25.00	25.00	25.50	30.60	22.90	21.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.49	0.71	-4.21	20	152	2012-10-01 22:02:33	2009-07-05 15:15:55	3	8	82	41	76	140	4	117.60	58	14.85	CHANGED	GPDFhTDllpVETuDHARLpLpLuYNWaF-V.stsc.t...tsp+hFoVsDFVGDuCKsIASRlRuAVAuhsFDcFH+NSu+lIRpAVFGhcpt..........Gps+...spLpFssNsLVlTsVDlQSVEPVD	.........GPDFhTDlIslETuDHARLpLpLuYNWaF-l..spp.csp...psu+LFSVPDFVGDACKAIASRVRGAVASlsFD-FHKNSu+IIRsAVFGh-ps..........scsR...cphhFstNsLVloSVDlQSVEPVD.............	0	41	49	61
+11812	PF11979	DUF3480		Domain of unknown function (DUF3480)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2031 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 350 to 362 amino acids in length. This domain is found associated with Pfam:PF01363.	25.00	25.00	29.40	28.90	19.40	23.10	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.16	0.70	-5.83	8	179	2009-07-05 15:08:20	2009-07-05 16:08:20	3	9	82	0	101	161	0	292.60	50	28.68	CHANGED	slPssPYLhGlLIpRhEVPWAKlFPLRLMLRLGApYRYYPCPLhSVRtRcslYGEIGpTIhNLLsDFRNYpYolPsVpGLlIHhEsp+ToIpIPpsRYs-lhKslNsS.s-HlLAhGusF...ochADuHLVClQN.-u......pYpTQAIsIcsQPRKVTG...ASFhVhsGuLKoSSGhhAKsSIVEDGLMVQIsPEpMptLRpALRsMKDapIsCG.l......-usDsQ.EhVsIpWV-s-pshNhG..VlSPIDs+uh-GlsSh+l..apuo-Ypsss.+IIRWTEVFhlps--c.pstsusstshoRLuEplA+usCtALsPHLcLLtpsGhsKLGLRlolDo-pVuYpAGSpGp.LPspYhNsLDstLlPll	...........................................lPssPaLhGlLIp+hEhPWAKVhPhR...LhLRLGAcY+.hYPsPLhSlRhRcslaG.EhGc.T.IhNlLsDhRNYpYoL.slptLhlchE.tposI.p.IPpp+as-h...............h.Ks.hNpS.N-HVluhGAsF...spcADSHLVClQN.sG........................sYpTQA.S..h.pspPRK.VTG..............ASFhVFsGALKoSSGalAKSSIVE...DGlMVQIssE..sM-uLRpALR-..KDFp.IsCG+s........Dut-.....p..Ehl.pIpWVDs.-.cp.hN.t..G..VhSsIDGpSh.....-.....u.....lssh+l......ht...ts.-a..c.s.s..t..+hlRhTEV..Fahtp-....pp.....hu......ssttphscplApAhshALsPHLchL+psGhsKlGLRVolD.oDp.VtapAGS..pGp.LPtpYh...NsLDssLlPVl...................................................	0	22	32	63
+11813	PF11980	DUF3481		Domain of unknown function (DUF3481)	Assefa S, Coggill PC, Bateman A	anon	Pfam-B_2819 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length.  This domain is found associated with Pfam:PF00754, Pfam:PF00431, Pfam:PF00629. This domain has two completely conserved residues (Y and E) that may be functionally important.	28.50	28.50	35.10	48.00	25.10	24.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.08	0.72	-4.16	6	219	2009-09-16 09:17:33	2009-07-05 16:10:11	3	9	43	0	64	168	0	83.80	51	9.77	CHANGED	-sos-T.lShpPsshLhoLDPILlTIIAMSulGVLLGAVC.GVVLYCsCh+suhocRs..hSsL.............ENYN......................FELsDGlKLKK-.hssQssh	...............t.............ps........LDPILlTIIAMSuLGVLLGAlC.GllLYCsCtasGhSpRs....hosL.............ENYN......................FELhDGlKhKhc.hNpQpsh........	0	2	8	23
+11814	PF11981	DUF3482		Domain of unknown function (DUF3482)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3168 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 289 to 301 amino acids in length. This domain is found associated with Pfam:PF01926. THe central region of these proteins contains a hydrophobic region that is similar to Pfam:PF05433.	26.40	26.40	26.40	27.20	25.40	26.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.61	0.70	-5.18	27	234	2009-07-05 15:13:17	2009-07-05 16:13:17	3	4	229	0	64	219	15	277.10	36	60.69	CHANGED	RcALAchsLHAhhp..FDoVAssh-sEt+LacslutLLcp.tps.LpcLlsspppptptRpptAsplIA-LLl-sAuhR..tplssptst....ppshpphppplRppEppshcsLLpLYpFcppDhpsscLPLhsttatpDLFsP-sL+thGlchus....GuAuGAusGsGlDLhsGGlTLGsuAslGAlsGGs.......hpsspphup.cl......huKl.......pGp.+cLsl....DsssLpLLhlRphpLlsuLppRGHAupcslpLts..sp....p..............pth.....cp..spLschLpcA....Rs+PpWSsLs.....................st..chtptpRpphlppLsspl	..................................................................................................................phLuRhsL.HshstFDoVA.sh-GEh+LacsLAhlL..p.hc.stLcRLhstpppphpphpppAtchIA-hLlDsAAhR..........pplspstsst..............................pshpphppplRphEpph...ptLhtLYpFhcs-hsssc..hhsttatpD.hFssEhL+phGl+hGs..........GsAsGAhhGhGl....DlhshGsoLG.hushlGulhGGh........h.ssps.......l..hsKl.............pGt.ppLps.....DstsLpLLAhRth.pLltsLppRGHAAps.slcLps...p...............tsW.............pt..s+LPp.Lp+A.Ru+..pWS.oLs.....................st...c.pptcRtthhptL....hh...........................................................................................	0	19	35	56
+11815	PF11982	DUF3483		Domain of unknown function (DUF3483)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3204 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 230 amino acids in length. This domain is found associated with Pfam:PF02754.	26.80	26.80	27.40	43.00	23.40	26.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.62	0.70	-5.05	14	145	2009-07-05 15:16:29	2009-07-05 16:16:29	3	4	143	0	52	139	9	221.60	55	35.17	CHANGED	hLstlLPhLlahuLuLsslGAsRRsthWRpGpsopVsalu..GLhAhP+RYLVDLHHVVtRD+YhS+THVATAGGhVluhsLslLsashuLtsp.....hLsahLLsAshs.MhlGulFVupRRh...sPPuRLS+GPW.RLP+SLhuFuluhhlsoLssA.G.hlssshGGWsLsslLuhul.hhGssEhhhGhshGGPMKHAhAGALHLAaH.RsERF...........sGGRSTuLKslDLs......ss.L	.......shLlssLLahulAhhshuss+RsshWRhGRuopsshhG..sLhAhPKRYhVDLHHVVARD.YlA+THVATAGGhluAhsLshlsaGhulau......hLshhlLlAshs.MhVGAlFVa+RRh.....ssPARLS+GPW.pLPh.LhAFAluhhLhsLssA..G.....t....h.G.....uaslhshLhlGl..GshphhhGhshGGPMKHAhAGhLHLAaH.RtERF...........uus..sTuLKs.DLpc...h.....	0	11	23	37
+11816	PF11983	DUF3484		Domain of unknown function (DUF3484)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3216 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 65 to 81 amino acids in length. This domain is found associated with Pfam:PF02491.	27.40	27.40	27.40	27.80	27.00	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.35	0.72	-3.14	15	535	2009-07-05 15:18:48	2009-07-05 16:18:48	3	4	530	0	32	179	0	75.30	36	16.84	CHANGED	V-hLAQtAVsG-phlc++P.s...........phcpsssstpsss.ppPtppsstsppp...........spcscpcls-Rl+uhFGshFD	....................VshLAQsAl+GEpsLp+QPlsh............hs.pa.spss.sspss.s..s...-.t.....s..hts.scs.s-................tsspsKsKls-RhRulhGsMFD.	0	3	11	20
+11817	PF11984	DUF3485		Protein of unknown function (DUF3485)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3236 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 223 to 526 amino acids in length. This protein is found associated with Pfam:PF09721.	26.10	26.10	27.60	26.10	25.90	25.70	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.23	0.70	-11.15	0.70	-5.24	59	191	2009-07-05 15:21:24	2009-07-05 16:21:24	3	2	160	0	96	206	48	204.30	17	52.21	CHANGED	thhhssslllh..hussshhhp.t......ptssssppshthhPtp.husWptssss............stht.phhsssphlh.ppY..tssp.....spsVsLaluYapsQ...pssphlHpPps.Ch...sus..GWphhspp..ptslshsst...shplschhhptts.....ppphlhYWathssph.h......ssshps........KhhthhstLhspts...Duull+lsss............ppsstsAtptlppFl.pphhsslsthl.	...............................................................hh...hhhhhhlh...hsshshhhtst.........tt...thss....tp.......ht.thPtp.husWpttstsh...........stht.phhsssphlt.psY......tsss........sptVsLalu..aapsQ...ptspt.lHsPps.Ch.....sus...GWphhspp..tt.s..lshsst.......thplschhhpt....ss.......ppphlhaWathsu.ch..h......ssthtt...........Khh.hhstlttpts...-ushlplss.............tts.ttu.thhppFh.pphhs.l.............................................................	0	36	81	91
+11818	PF11985	DUF3486		Protein of unknown function (DUF3486)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3271 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are about 190 amino acids in length.	25.00	25.00	25.90	25.00	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.95	0.71	-4.22	34	265	2009-07-05 15:23:11	2009-07-05 16:23:11	3	2	219	0	56	231	5	173.50	25	95.02	CHANGED	Ms++SpV-hLPts...lRphLpphLpspshothclLppl.phh.t.......sh..........plS+SulpRYup+hEphhtpl+pupEhAchhspphu-.spschuchlhphlpohhFcshhsht-stcpp........hchLsplApslsplppAustpc+hpt-lRpphttpsss........ts-phsppsGl......Ss-shspIRcplL...G	.............................huRtSpl-.hLPp...s....l+p...hLpphLp-pshoth......c.hl.ppl.phh...................sh.......plS+SulsRY...up.......+h....-p....hhtpl+pspEh...uchhspphu.-...spscho.chlhphlps.hacthhphpEstpss..............thlsplutsh.tpL...ppAuh.tpc+hcp-.....l.......+tphttthsp.........s-ch....s...tp..sGh......ot-hhptl+p.lLG.......................................................	0	24	45	51
+11819	PF11986	PB1-F2		Influenza A Proapoptotic protein	Mistry J, Gavin OL	anon	pdb_2hn8	Domain	PB1-F2 is a protein found in almost all known strains of Influenza A virus - a negative sense ssRNA Orthomyxovirus [1]. It originates from translation of the viral polymerase gene in an alternative reading frame [1]. PB1-F2 consists of two independent structural domains, two closely neighboring short helices at the N terminus, and an extended C-terminal helix [1].  Although the protein has originally been described to induce apoptosis, it has now been shown that PB1-F2 more likely acts as an apoptosis promoter in concert with other apoptosis-inducing agents [1]. PB1-F2 promotes apoptosis by localising to the mitochondria where it destabilises the membrane. This will cause release of cytochrome C which activates the caspase cascade of apoptosis through the endogenous pathway [1]. In this way it acts like the Bcl-2 protein family which are physiological apoptotic regulators in cells [1].	19.50	19.50	19.50	24.30	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.24	0.72	-3.95	24	10057	2009-07-06 12:30:56	2009-07-06 13:30:56	3	1	10020	2	0	3113	0	83.60	71	99.95	CHANGED	MEQEQDTPWTQSTEHINIQKRtsGQQTQ+LEHPNSTQLMDHYL+TMsQVsMHKQTVsWKQWLSLKNPTQsSLKTRVLKRWKLFsKQEWTN	.MEQEQsTPWTQSTEHhNIQKRGsGQQhQ+LEHPNSTQLMDHYLRhMSQVDMHKQTVsW+.WhSLKsPTQtSL+T+sLKpWK.FNKQtWTN.	0	0	0	0
+11820	PF11987	IF-2		Translation-initiation factor 2	Mistry J, Gavin OL	anon	pdb_1z9b	Domain	IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes [1], Bacteria [2] and Archaea [3]). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits [2]. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyses the hydrolysis of GTP following initiation-complex formation [2].	20.20	20.20	21.20	20.30	19.20	20.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.32	0.72	-4.18	243	5391	2009-07-06 13:34:25	2009-07-06 14:34:25	3	51	4886	6	1587	4288	2608	108.80	42	13.02	CHANGED	s.....oL-shhsphp...pu..p...hcpLslIlKADVQGSlEAlpsuLpKls..s--VclpllcuGVGuIoEoDVtLAsA.S..s......AlIlGFNVRssspA.+chA-pcs...V-IRhYslIYcll--l+t	......................................spL-shhpphp.....pG..-.....hcp..lslllKADV.QG.SlEAlpsSLtKls......s..-....-.............V....+V....pllcuuVGuIoEoDls.LAsA.S.s............AlIlGF.NV.R.s..s.s..p.A.+c...h.A...-......p....-s......V-lRhYslIYclI--lc........................................................	0	547	1002	1339
+11821	PF11988	Dsl1_N		Retrograde transport protein Dsl1 N terminal	Mistry J, Gavin OL	anon	pdb_3etu	Domain	Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum [1]. It is localised to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles [2]. It is comprised primarily of alpha helical bundles [1]. It complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein [1].  A central disorganised region between the N and C termini of Dsl1 contains binding sites for coatomer [1]. The C terminus of Dsl1 contains a binding site to the Sec39 subunit of the Dsl1p complex [1].	25.00	25.00	43.40	43.20	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.97	0.70	-5.58	7	25	2009-07-06 14:57:28	2009-07-06 15:57:28	3	2	24	3	13	24	2	341.10	49	47.20	CHANGED	plhsspspllptltpDP.lh.csss+.psp.....hDhpslLpp-spLsc-LptLppLKhlusLlhEapsNh-lhELENCYYSLQNL+KKh+ssss.htpuhpFQQSlsoalDsLHlpLls+lhcllsphFWpIstsohpFppplphtcDcsp...h-Y-shhpFlppsaFscshlD.ppWhItshshu-.p-pVpppLsoIhpsYlphsplhctlKphlFscphphohps....p+LplspS...Gt.hlscplpSatsLssFl.sslo.cDpttlhhcLGsslssEhhKhlKpNupplLpppss.hKp.ls.lN-pLppLSpcot..sWsYsGp-lpcLLNDcplapsLhLDplhpppl.cIR	..u.LhsNKsEIIcpLhKD....PLll.cs-o+..coNt............phcLDss-LLpREuhLusELphLssLKTh.sLIcEhKTNlplLELENCYYSLQSLRKKh......R..N.NuuaL.KQSFsFQQSluTYVDTLHL-LVooLYcILTstFW+ITEN.SIpFsPoVEaG+D...+V+...IEYDTFM-FVsQQYF..PcGsLDspuWFIhDMs.uDuQEpVRuKLNTIhK-YhsLSpllshIKsuIFhsG+cISYEs..ppshLlFuKS..SS..+GpcslossLsSFcuVsDFhLDsLuh+D++oLuhcLGPLhsTEFTKFVKsNASlILcshc.SPLKsLVSsINsKLs+......Lsu+Sc...sosWoauGcEIpDLLhNKplYaNLLLDKlLEuHIo-IR.	0	1	6	12
+11822	PF11989	Dsl1_C		Retrograde transport protein Dsl1 C terminal	Mistry J, Gavin OL	anon	Manual	Domain	Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum [1]. It is localised to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles [2]. Binding sites for coatomer are found on a disorganised region between the C and N termini of Dsl1 [1]. The C terminal domain is involved in binding to the Sec39 subunit of the Dsl1p complex [1]. The N terminal complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein [1].	30.00	30.00	30.30	30.50	29.70	29.90	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.78	0.70	-5.25	5	58	2009-07-06 15:01:51	2009-07-06 16:01:51	3	4	55	1	39	61	0	287.90	29	38.41	CHANGED	DGWDEEWDID..ID-lcppsspt...........p-cIpITpLPctFtpIhpcFEpuscslucupV-spYhtYKFNLLQTuFFAMsosKasN-WaQLYpDMRYlhoc..NscLhRLpELstRhhEsNLshp+KhVppllpcQLspL+cNE+sPsWDsTIcsLLPFIccEllssLp+Itt.-up+aLLsFLsFLaNDCllsNILpWcIISEKNSENLSELIpLllNuT-IsuLsspPcYR+hREKluIluKlLPLHLKDIMEMFYNGDFYLFuTEEIIQWIlLLFADTPLRRDAIDDIpEIRpEupD	....................................................................................sWs-..s.Ws.-......h-.ctt.pptppt........................t...ppplplTplPp.hhtl.ppap...p..sh.sp..s....t.hp.p..p....h.h......ths.......l..L..t..o..hhAh....sps........pa..s....p..s...h.LasDhpYlhp..c......spp..L.chp.......-hs....h......p.h....lp.............pphp.phchV..h........pl..lpt..p..hp.p.hp...c.s........-cp..s...sh..ct.shppl...l.shl.h..ppl....h.p....h...ppl.pt...ppt.....phlhp.hlshl..hNshllppIlphp.ISEhpSppL.......ucLls.......ll..h..s.........s..o..c..l....t..tL..s....p...ps....s....Yh...c...s..hpKFshltplLssHLK-IM-hFYpG-ha..FuT-ELlphIchLFA-osLRcssIs-Ih-hRt...........	0	10	22	38
+11823	PF11990	DUF3487		Protein of unknown function (DUF3487)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2242 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 121 to 136 amino acids in length. This protein has a conserved RLN sequence motif.	25.00	25.00	29.00	28.80	23.90	22.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.62	0.71	-4.72	25	230	2009-07-06 16:44:55	2009-07-06 17:44:55	3	2	188	0	64	200	9	119.40	36	94.45	CHANGED	-sTlsFLP..cRLNp-PlVhRGhTssEhhlssshuhshG.lllGlsLuhl..suhlt..hlPshhllsslhslhlGushLpRlKRGRP-saLaRp.lph+lstph......lGsppLIh+SGhWolRRo....................tpt	..............tTlpFLPpRLNpcPl.Vh+GLTssEh.hlsshh.us.ssG.hllGlP.luhl..hs..h.h.h.hhPss...s..llsshlslhlGu....th..LpRl...KRG+P-saLaRp.Lp.h.p...lsphh.........lGsppLIh..+SGsWohRRo........tp..................	0	7	28	51
+11824	PF11991	Trp_DMAT		Tryptophan dimethylallyltransferase	Assefa S, Bateman A	anon	PFAM-B_2054 (release 23.0)	Family	This family of proteins represents tryptophan dimethylallyltransferase (EC:2.5.1.34), which catalyses the first step of ergot alkaloid biosynthesis [1]. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 390 to 465 amino acids in length.	25.00	25.00	28.60	25.50	23.80	22.30	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.09	0.70	-5.24	53	313	2009-07-06 17:00:22	2009-07-06 18:00:22	3	10	118	12	161	321	0	311.10	24	78.37	CHANGED	t-pch..WWcpouPhluplLpsAs.YslcpQapaLthapphllPhLGPaP.........ttttpahShl...optGhPlEhShNa........ppstp.sVRhshEPls...hsGTs.tDPhN.ptustchlpcLsph.hssl.DlphacaFtpplslspp..-pttlpppt..................h+s.....pthluhDLc....sup..hslKsYh......hPthKuhsoG.h.ssppllhcul+pls.t......thtsuhphlcsalssps........................sthpsth.luhDh.lsPs...coRlKlYltp.p.sohsplc-laTL.GGRhs..s.ssshcGLc.hl+cLW.pllsl..........sh......................ps.thstss..stphs.......hhhsa-l.pP........Gp.shPp.......splYlPl.h..............uhsDttlApuLspF.acphG..apchApp.YtssL	........................................t.Wh.ptsushhsphhttus.Ys.ptQhphLhhhtphl....lPhLGshP............tt..hahShl...ottusPhEhShsh.............spst..hlRhshEPls..hsG..st..tDshN.ptshtphlppltt................ssh...chphapthtpplhlstp...ptthh.tt...................hhs...............p.hluhDhp.......ssp........hshKsYh...........hPth+uhssu.............s.......tplh...hpulcpl.........thtsuhphlppahtpts...............................ththth..luhDh.lsss...........coRlKlY.hhpt..p.sshsplpchhTL.GGRh.p....s....ts.culp..hlcplW.tlhsh.....t........................t.....htt..t.ths..........hhhsapl.ps........sp..hPp........splYhssh..............s.sDhtlspslspahpphG..ht.t.sp..Y...............................................................................	0	28	75	132
+11825	PF11992	DUF3488		Domain of unknown function (DUF3488)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3123 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 323 to 339 amino acids in length. This domain is found associated with Pfam:PF01841. This domain has a conserved PLW sequence motif. This domain contains 6 transmembrane helices.	25.00	25.00	25.10	25.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.05	0.70	-5.79	60	397	2009-07-06 17:02:56	2009-07-06 18:02:56	3	6	379	0	159	408	140	317.90	25	47.85	CHANGED	ptlsR..psh..ha.LL.hshshllhPhhtplPhWhsu...lsshsllWRshlhhtph............sh...PsR....................allsslsls...ussslhhshsp.hhuh-sslsLLllhhuLKhlEh+spRDshlllhLuaFllhssFlhsQulhhshhhllslhhlhsuLlsl....pt.stsp.......................h..tpsh+huuplhL.ulPLhllLFllFPRl.sPLWtlP.sstsupTGLSDsMsPGsIupLspSsplAFRs.pFsus............P..spspLYWRGhVLppaDGcsWpts...........tttthtss.stsss.................t.tupslc...YplhhEPopppWLauL-......hshsss....sssths..sDhp.hhsp+P..lspph+YpspShsph	.........................................t.........h..hh.lL..hshhhsl.hPh....h.hplPh...hh...hs...lh.s.h...shhhp.h.h.h.hht.ph.............h..P.sp....................hl.h.shlhls...shhsl...h...hp..h.ss..h.......h.......u...h-susslLlhhhsLK...hlEh+st.RDhhhllhlu.h..FhlssshlhsQu.....h....hhshhhl....ls..l....hh..hhss..L.l..tL.......pt..sptp.....................................................h...ttsh+h.ust.lhhhu.l.P.L...hl...lLFlhhPRl...s.....PL.Ws.l........P.......s.s........s...p.....u.p...T..G.LSD.p..hsPGslupLspssplAFRs.pF.sss...............P..s.p........ph.....YWRuhVhppa...D.....G.p.pWpts...................................thts..sts.p....................................................tspslp...Yplh..hEPs.p.ppa....LhuL-........hshsts........ts..s..tht.....s-hp.lhtpps..lsp.h.hpYphpSh......................................................................................	0	48	110	140
+11826	PF11993	Ribosomal_S4Pg		Ribosomal S4P (gammaproteobacterial)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3290 (release 23.0)	Family	This family of proteins are ribosomal SSU S4 p proteins. This protein is found in gamma-proteobacteria. Proteins in this family are typically between 162 to 178 amino acids in length.	25.00	25.00	28.70	33.10	19.60	24.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.91	0.71	-4.47	19	166	2009-07-06 17:08:16	2009-07-06 18:08:16	3	1	165	0	38	120	7	163.90	44	97.59	CHANGED	MQlcslt...LINEhQhGspLNpAVcpuRRu-.FuLlLuMLSpDsRDhs.hch.pstps.......pcptLRppFpls...psQsLtustsshphustpAphap....ptGhsuh+LpptLsPEsLshpsp-stsls-plhpNhShpsR++ltsp............pshphs.tphYspLssspptsplttp	........................................MQlHTLDKAslIsElphGpulspAV.pc..GRRAD.FALLLuhhSsDVRDsoPl-plcssss.......oEpsLRpcFELu...pPQ.tLcsDpSSYpluAcQAslFH.........puGhsSAKLuHYLpPEsLsaRPpDTpsLPEEVYtNLSGHpRR+Lus+............psspl.stchYcpLssAhRpsplps.t.......................	0	6	14	26
+11827	PF11994	DUF3489		Protein of unknown function (DUF3489)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3545 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 84 to 211 amino acids in length. This protein has a single completely conserved residue W that may be functionally important.	28.30	28.30	29.20	30.50	28.20	27.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.47	0.72	-4.03	26	127	2009-09-11 08:24:30	2009-07-07 12:41:14	3	4	70	0	54	132	26	73.80	42	46.18	CHANGED	scsspsRp...................soKQsplIshLp+PcGA...TlspIscsTGWQsHTlRGsluGsl+KKLGLslso-Kss...u.sph..YRIs	............................................tsRt................soKQAplIsMLp+PpGA...TlspIspATGWQsHTVRGshuGshKKKL...GLslsScKss.......uttRs..YRI.................................	0	20	40	48
+11828	PF11995	DUF3490		Domain of unknown function (DUF3490)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3558 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF00225. This domain is found associated with Pfam:PF00225. This domain has two conserved sequence motifs: EVE and ESA.	25.00	25.00	31.50	28.70	24.40	23.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.13	0.71	-4.68	12	129	2009-07-07 11:50:29	2009-07-07 12:50:29	3	9	24	0	81	127	0	153.30	50	17.22	CHANGED	-Fc+QpppII-LWpsCpVSLlHRTYFaLLF+GD.uDpIYhEVELRRLoaL+pohupss....A..ss.pslolsSSlKALpREREhLuKhhsp+hotEER-pLYhKWGlsLsoK.+RRLQlsp+LW.osspDhpHVcESAslVAKLlGFsEsGpts.KEMFsL.................sFss.s	.............pFc+pppcII-LWcsCpVSllHRTYFFLLF+GDsuDsIYMEVELRRLoaL+poaupss............tsh...ss..sh.....ohsSSh+sLpRER-hLu+pMp++LotE.EREpLYhKWGlsLsoK.pR+LQlsp+LW.ocspDhpHlcESAslVAKLlGahEsGps..KEMFuL.sFss.s..................	0	9	48	65
+11829	PF11996	DUF3491		Protein of unknown function (DUF3491)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3393 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 286 to 3225 amino acids in length. This protein is found associated with Pfam:PF04488. This protein is found associated with Pfam:PF04488.	25.00	25.00	25.50	25.40	24.20	23.60	hmmbuild  -o /dev/null HMM SEED	936	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.47	0.70	-7.05	8	259	2009-07-07 11:54:01	2009-07-07 12:54:01	3	4	123	0	7	238	0	528.00	32	36.34	CHANGED	AVh-ssSRaacPPLospNcpuTVIAGcoPLTVIPlRLL---osERlcpAhuYKDYKIplpGGpGGLTVQIGGAGaYslTusP.uscNsISFRAIPtsFuVsFsLS.+tpQsVPLh+PNG.TclplLKIpQKGFsTIlGSuuGpDpLTGN.+DT+FYlSoGGGslaSGuGpNpYaIP+.LpssLsIsLosNSssHplhLs.po....hEh+ssussLoLI..h.thtsssIal.shDspsphspasssFpV+hsDGITlpAlc+tsst...........spLuVpoCD.ptWptpaPEEsuas-sIlcaL+chsWhLAPcVplhtpcupssYhshp+pLVYp.Pc.aSElplpupcsYpTtVpGssGsoYIl.s..sssspspslcIhLA-DsspPQTlDLSsllPoLVpG+hss....ssSIsLpl..SSs+YslsLolSWpscs..lPppThlplpPpcphpLG-ha+hL..ppssupWssLa+suhlIPcch.slLSlNNTshLMls+spps..sEHlLulENpuslshKlhGpLhSGaIKGu.....Wcs.spshsslp+hsloIPsHshpYLsFcGc.......cNlLF+ShLcutsLcs+spsphplS++pWppYD-IpVp....AToLpLpcFpRYpIuotscsLSRpLMYAQshVpIssRDlslKLFYl.REssGIGAlRLlFKNFFpESM-shscpTLEKEsKPlLsusPcphIssuY+sHLclhLG-cpLNLAplVpEFusop+IlshpcDhssHtllh.psppspsLsllTaTlssps-ssptt.p.p.hahDsh.pcY+.LPhsThs-s.YYLsPsoGDLYlTplls..scspsQAFll+LKsaKppWtcapphllSusHpphpp.l..ssTsLpFsGPElp+hEIDaspsss.h.h.sscllShSshlF.ss-QVlpYsP+hupQFaSh.-YMLW-L+-Rsptupc......A+saDsYLh-ushphhc+NspWKIssslLcaAlG.YYR	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	5
+11830	PF11997	DUF3492		Domain of unknown function (DUF3492)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2107 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 259 to 282 amino acids in length. This domain is found associated with Pfam:PF00534. This domain has two conserved sequence motifs: GGVS and EHGIY.	23.30	23.30	23.40	23.40	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.73	0.70	-4.85	39	322	2012-10-03 16:42:30	2009-07-07 16:23:34	3	7	290	0	121	316	12	260.00	28	41.01	CHANGED	s-lsLllEGTYPYVpGGVSoWlcplIpshP-hpFsllhlGuptcchtphpYplPsNVsclcphaLhst.........t..............tppup..ppshpthcplpchhcpsst.......stthhpph......hhtltpss..shs.psFLtScps.......WchlschYpcht.....spsSFsDaFWolR.hhtPLhtl..lupsl.PtsclaHslSTGYAGhLGulhptppspPhlLTEHGIYT+ERcl-lhpupWI...............hshhRchWl+aFctlu+hsYptA-pIluLactNRphQlptGAss-	............................................................................hclsLlhEGoYPYVpGGVSuWspplIpu.hs-hcFslhhluuptpp.s.phtYplPsNVsclcphhL.st..............................................tpttpptthphhpphhphhpp.hts...................stt.h..pt.h......h.tLtptt..thshtshL.tScph..........................ac..hl..pc.....hhpphh.....................spssFs-...haWsh...Rp..hht..sl.h.l..................lspsl..Pps..clhHulSTGYAGllGshhp.t.ppstPhllTEHG.....I.....YsRERch-lhpupWl......................shh+phWlpaFttluchsYptAc.lhsLap.t.spthQhphGAs........................................................................	0	35	73	104
+11831	PF11998	DUF3493		Protein of unknown function (DUF3493)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3788 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 79 to 331 amino acids in length.	25.00	25.00	25.20	25.40	24.00	24.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.27	0.72	-4.09	21	125	2009-07-07 15:28:10	2009-07-07 16:28:10	3	7	83	0	70	127	107	77.70	35	29.61	CHANGED	hssptcs+LhsEspsPaRGLR+hlalAhuASuslGhhlhhhRlhu.......Gssl.tslsNLulQlGuluLhshLhhhEpp	.....h...pptt+LhuEspuPaRulRpFhYlAFsASuslGshlhls+Llu............ussl.....pslsNhulplGulslhshLahh-pp........	0	22	52	66
+11832	PF11999	DUF3494		Protein of unknown function (DUF3494)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3080 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 243 to 678 amino acids in length. This protein has a single completely conserved residue G that may be functionally important.	25.00	25.00	25.80	25.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.50	0.71	-4.69	43	181	2009-07-07 15:31:23	2009-07-07 16:31:23	3	33	84	5	76	193	13	198.30	33	42.53	CHANGED	lLutoul.TssGs..osls.Gsl.GsSP.susu..lsGFs....hss..............Gslasssh.............shspAhsDhtsAYs...........sAsups.ssshstl..ssGsl.uGhTLsP....GlY.....ch.suu...lslos.slTLDutG....sssuVaIFQlu...usLosu.uuu.......plhLs....sGApApNlFW......Vuuu..solGssosFpGsllups...u.Iol....sTG.....uols.GRhLAps..AVTLsssslsp	...............................................................hLutsul.ossss....osls.Gsl.GsSP..uou..lTGFs...shss...........................................sGplauush....................hhspAhsDhtsAYs...........sAAups.......s............s.s..httl......ssGpl..GGhT......LsP....G..lY.....ph..ssu...lslou..slTlDutG......ssssVaIhQhu...usLssu.uus.......pVhLs......sGAp.ApNlFW......pVuuu....solG...s...suphpGslLuts....u.lshsTG..........uo.ls.GRhLups..AVTLssssl..t........................	0	20	68	75
+11833	PF12000	Glyco_trans_4_3	DUF3495;	Gkycosyl transferase family 4 group	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3335 (release 23.0)	Family	This domain is found associated with Pfam:PF00534.	25.00	25.00	25.10	27.10	24.50	22.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.98	0.71	-4.63	53	208	2012-10-03 16:42:30	2009-07-07 16:34:35	3	4	180	0	79	213	126	168.00	33	40.39	CHANGED	ppGHclshls.tpsptshs.....GVcllpYps..pctsstssas.ahpshEspsh+GpushcusppL+pp.GapPDlIluHsGWGEsLFL+-laPcupllsYhEa.aYpspGs.DssFD..PEa....sss...psth+........lRh+Nhs.hhphppuDhuloPTpW.......QpupFPs.a+s+IpVlHDGlDTsthp	..........................................t..upclshls.ppsptth.......GVphltYps...scts...sspsa....hhpshEptsh+GpushcsstpL+pp.GFtPDlIluHsGWGEsLFl+-laPcs.llsYhEa.aYcspGs.DssFD..P-h....shs..pshhp........lRh+Nss.llslpt....sD.hGloPTpW.......Q+spaPs.h+.s.+IsVlH-GlDTshh.t...	0	17	57	68
+11834	PF12001	DUF3496		Domain of unknown function (DUF3496)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3407 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 110 amino acids in length.	30.70	30.70	30.90	30.90	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.24	0.72	-3.81	7	174	2009-07-07 15:42:55	2009-07-07 16:42:55	3	17	36	0	67	132	0	100.90	43	13.79	CHANGED	h+oQMELpIKDLESchu+hKTuQtDhspoELEcYKpLYl-ElKlRcSL..SscLsKosE+LAElsTKLhlE+cQ..scShhoohsTRPslEsPCVusLp.shshNRhhIPR...-slhl	....................psphELplKDLEscl.S+hK......T......upc-s.............poE.LEcYKphahcELKsppSL..SpKLs...K..o..sc+lA-lsTKLLhEKpp..p+shhoolssRPs.Es.PsVtNLs.ShslsRphhP+t..................................	0	8	10	19
+11835	PF12002	MgsA_C		MgsA AAA+ ATPase C terminal	Mistry J, Gavin OL	anon	pdb_2r9g	Domain	The MgsA protein possesses DNA-dependent ATPase and ssDNA annealing activities [1]. MgsA contributes to the recovery of stalled replication forks and therefore prevents genomic instability caused by aberrant DNA replication [1]. Additionally, MgsA may play a role in chromosomal segregation [1]. This is consistent with a report that MgsA co-localises with the replisome and affects chromosome segregation [1].  This domain represents the C terminal region of MgsA.	21.00	21.00	21.00	23.60	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.93	0.71	-4.57	278	4662	2009-07-07 16:02:56	2009-07-07 17:02:56	3	19	4329	28	1089	3504	745	165.20	43	37.81	CHANGED	GSDPDAALYaLARMl-uGEDPhaIARRLlhhAuEDI.GhADPpALtlAhuAhpAhctlGhPEuclsL..AQAllYLAsAPKSNusYtAhspAhpsl+p...ssshsV.PhHLRNAssphh+clG....aGpsYcYsHDhs....sua.ssQpY..LP...-p.lps......t.......aYpPs.ppG..hEpclpccLpplcp	.............................................GSDsDAALYa.hARhlcA.GtDPhalARRLlhhAuED...IGhA-PpAhtlAluAh.puh..pc.lG.....hP.E.u..c..l.sL..Ap.All.aLAhuPKSNusYpAhstAhssl.+p....s...s....s...h....sV.PhH..LRsA..hph.h...K....c.LG...................h.G.ps..YcYsHDhs.........sua...ss...........QpY..hP-clts.......pp....aYpPs..spG...hEtpltpphthlt.p.......................................	0	359	698	920
+11836	PF12003	DUF3497		Domain of unknown function (DUF3497)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3419 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 213 to 257 amino acids in length. This domain is found associated with Pfam:PF02793, Pfam:PF00002, Pfam:PF01825. This domain has a single completely conserved residue W that may be functionally important.	27.20	27.20	27.60	27.20	27.00	27.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.31	0.70	-4.98	32	930	2009-07-07 16:18:38	2009-07-07 17:18:38	3	137	93	3	416	750	0	222.40	24	14.93	CHANGED	tp+hpsscss..p.lspcLtchT.....ps.shauuDlhssscllpplsphhs.pttthhsspccst................................................................pshVpsssNLLc.pstppWcplppscp....suopLLcslEchshhlApsh...hth..pphhhsssNlhLplthhssps.hps..hFPp..........hphstsplplstpshptssp........................................sG....shlshllY+sLGtlLsspssshth...tp.....hpsssp....hlsosllssslspp	..........................................................phhsGcsss..plsppLtchT......ps..sh..auuDlhsolclhppls..s.hhs...p....htth....h....su....s.p-sthp..............................................................pshVpslssLLpscshptWc....chppsct........sushLLcslE-huhsLApsh............hth.........p.ht.....hso...sN...l........h....L.pl.t.h..lssps..hps..hpFPp.................................stsstspl..plst.sshp.ssp...................................................................su......hhlshllY+..sLGthL.ss..p..p..ss..hth........t...............t.stp..................hlso.llsssl.....................................................................................................................................................	0	73	107	227
+11837	PF12004	DUF3498		Domain of unknown function (DUF3498)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3438 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 433 to 538 amino acids in length. This domain is found associated with Pfam:PF00616, Pfam:PF00168. This domain has two conserved sequence motifs: DLQ and PLSFQNP.	29.50	29.50	31.40	31.40	28.80	29.20	hmmbuild  -o /dev/null HMM SEED	495	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.91	0.70	-5.36	7	291	2009-07-07 16:20:56	2009-07-07 17:20:56	3	9	66	2	120	241	0	410.40	38	42.45	CHANGED	LpDlotALsNPsslppps.......spc....+sss........P.susulSoGlQp.hh.pDls..............u.sDhsRLPSPT...........................tsKDlFaVo+sshhpsSPuhsS.S.S-hsEs-h..thssG............+SlShhDLQ-...............spstp........uhs......s...........hstpsspushsss..lpp..........ssph....css.sp..thLhPLSFQNPVYHhusshP...ssst.....cuuopscuosSSH.........................SssE-h.h..........h..pt......c-hst+ss...-hoccphshst...ttp.....slPppsosG.t..R+h.............sututpuph......Pssh.....t.h..........pssshhss..................p.spsG.u+.+QpopSppt-sss.+stuh..tts...........SPss......ssl-RTAAWl.N.N....-...........c...spc-hppsEK.....YppEIshLpE+LRhSsp+L-EYEtRLhsQ-pQhQKhL.EYQtRL--SEpRLRp.Q.-KD.QhpuIIsRLMuVEEEL++DHu-MQtVl.-uKQKIIDAQc+R...hsuLpusss............................RlhsuLs.lpE+a	................................................................................................................................................................LtDlphuLpsPt..p..............t-..h..s............s.h.tu.SuthQt.hh..pshs.........................Dht+L.SPo...........................tspD.aahs+s....hh........psu.po.o.S-hsE.-...ph...ss............+SlShhDLQs.............................stshph..ts..s.......s..s.................................h..t..ss......thsth.....plpp..........ss.h.......css.....sp..thh.PLSFQNP.laphsssh.P...h.Ptu............cuu......t...sh..us.SS+.......................................S.pSE-hth..........................h..ps..................--hspp.s.s.......-hsR.R..phs..p.....ph............h.Pt...Q..so.sG.t.....Rpht............................ss.....s.s...pups............Pssh.........tph............................SoGs.h..u.......................................................t.s......t.G..sR..R.QQ.SpSpc.........p.ss....p......p.....s.h.tt.tts........................................oPss................ss..-RT...s..AWl.s...st...-................ch.p.pcph.p..psc..........................................hpp..-IthLp...-+L+hSs++LEEYEpchhsQEp.phpKllhpYp..AR...LE-...uE.....cRLRpQQt-KD.QhKuIIuRLMsVEEEL++DHs.......c.Mptsl.-sKQ+lIDA......QE+p...IsuLcuANs............................RLhsAlttlpt.....................................	0	16	27	63
+11838	PF12005	DUF3499		Protein of unknown function (DUF3499)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3439 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	25.00	25.00	27.20	30.20	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.86	0.71	-3.95	18	376	2009-07-07 16:22:24	2009-07-07 17:22:24	3	1	375	0	101	250	99	115.10	47	91.41	CHANGED	ss.RRCSRsuCucsAVATLTYVYADSTAVlGPLAshuEPHoYDLCspHAcRLTAPhGWElVRlsst.t.....sstPssDDLhALA-AVREAup..stt.s.s.........................ssshssP........pssR....RGHLRVl..........s-s	....R.C.+suC.t.AsATLTasYu-STAVlGPLAs.t.EPHuaDLCspHAp+lTAPpGWEllRhsu......................sscPssDDLhALAsAVREuGhstst.hhsts.....................................................................ss.....tstthsR........RGHLpVlsD.s.....................................................................................................................	1	33	78	97
+11839	PF12006	DUF3500		Protein of unknown function (DUF3500)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3479 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 335 to 438 amino acids in length. This protein has a conserved GHH sequence motif. This protein has two completely conserved G residues that may be functionally important.	27.20	27.20	44.20	29.00	27.00	23.30	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.11	0.70	-5.49	36	209	2009-07-07 16:26:39	2009-07-07 17:26:39	3	7	142	0	112	226	111	297.20	27	81.26	CHANGED	stpspsssssshhsAApshLssLsscQ+ppshhs..........h..Dssptps.........W.s.h....sh......RsGlslsphsscQ+phshslLpssLS...spGapcstslhth-.p.......hL...........phtttt.........................hs.tpYalslFGs...Pus...s..psWGapatGHHlulNhsh..ssspl.shoPhFhGupPsthpp........hsG..hp.....sLtpEcshuhpLhpuL....sscQpppAhltpth...............................................sc.hphsushtc.....................h..pGltsupLsssQpchLhsllpp.Ylshhspphsc..tphscl..ptthspsaFuWhGs....htsscsaY..aRlpuPshllEassps..................sstsHlHolhRssss.DaGts	......................................................................h....t..htthhtAupshlssLsspQ+ttsth.......h......ss.phpp..............................................W.s..........h.............+tGlpl.sp..hss..t..pppsshplLpssLS....spGYpcshshhths.p.....hLt..........ph.st.......................................................................hsttsY.hslFGp.....Pus....................s...psWuhphtGHHlslNhhh...sspl.shoPhFhGspPshhst..................htG...hc.....hhttEpphuhpLhpuL....ssppptpAhl.tth...............................................p-.hphsus.tc.....................hs.pGlhsu..phospQpphlhsllpp.althhspphtp..tphppl..ptthscTaFuWhGs....htssc..s.hY..aRlpuPslllEaspps..................sst.HlHolhRs.ss.DaG..t.................	0	49	81	103
+11840	PF12007	DUF3501		Protein of unknown function (DUF3501)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3488 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are about 200 amino acids in length. The structure of protein Swiss:Q63J81 from B. pseudomallei has been solved. This protein contains two domains, domain I (1:31, 46:81) is a helical domain, domain II (32:45,82-193) is a mainly beta protein with a beta barrel. According to crystal contacts the proteins probably functions as a dimer. The gene neighbourhood analysis suggests that this protein may be functionally related to rubrerythrin and ferredoxin. The wedge surface between the two domains might be functionally important. The fold of this protein could best be described as a circularly permuted C2-like fold (details derived from TOPSAN).	25.00	25.00	104.10	103.70	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.09	0.71	-4.63	22	127	2009-09-11 15:56:04	2009-07-07 17:34:23	3	2	125	2	46	112	664	190.20	41	94.10	CHANGED	hplshsslhs.hpsYu+hRtph+spllthK+pRpVplGstlslhFEsptTlRaQIQEMl+lE+hhc-tsIpcEl-sYssLlPsuusLpATlhIEhsc.s-RcptLscL.hGlccplalclsstt.tlhuls-tDhtRpss-.+sSoVHaL+F-lsss.hsth+s...uss......ltlGsDHssYshpst..lsssstpuLhsDLt	........................plTRssLLo.lEsYuKlRtph+s+llshK+cRtVplGs+lpllFEscsTlpYQIQEML+lE+lh-cpsIppEL-AYsPLlPcGssLKATlhIEhps.scR+ttLs+L.hGIE-claLcVssct..VhAIA.....-EDh-R-su-.KTSuVHFLRF-Lssshhsth+s...Gss...lplGsDHPsYshpst..lsssltsoLsuDL.....	0	14	30	40
+11841	PF12008	EcoR124_C		Type I restriction and modification enzyme - subunit R C terminal	Mistry J, Gavin OL	anon	pdb_3evy	Domain	This enzyme has been characterised and shown to belong to a new family of the type I class of restriction and modification enzymes. This family is involved in bacterial defence by making double strand breaks in specific double stranded DNA sequences, e.g. that of invading bacteriophages. EcoR124 is made up of three subunits, HsdR, HsdS and HsdM. The R subunit has ATPase and restriction endonuclease activity. This domain is the C terminal of the R subunit [1].	21.60	21.60	21.70	21.70	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.93	0.70	-5.20	79	1157	2009-07-08 08:20:11	2009-07-08 09:20:11	3	9	1042	10	158	990	58	263.60	21	28.79	CHANGED	hlLhcsapchhcpapc............slp-Lpphhsss.......thspl..ts-psccpFlchFpch.+htstLpsas-.as.........................sptpht................hsppphp-acutYhsltpcl+cpp...ppppt.........s....pDlcF..El-LlcsscI...........NhDYIhpLltch..........ppspppppt..hcplhchlps..s.thcsccclltpFlpplph...........ph.sppslpctappatppcppcplpplspppsL....stctlpphlsshh...tptph..ptsplsc......hls.hphth......tpphp.....hcpplhpcltshlc+a	..............................lLhcsac-hhptapc...........................shpcLpphhsss....................hspl...tsEppp+cFlchFtph.+hhphLpsa--.ap...............................s.ttht........................hsppph..p-Yc..utY.slhcpl+...cppt..pppp.................sh...sDl..sF..El-h.h+stp.I...........NhsYIhpLltph.....................pppt..pppp.hc.....plcc.....hlpp........s.p.+tcccllppFl.p.php..................ph.psp...s.ltpta.pah.ppcpppchpthhpcpsl.....sppth+phhsphh...tt..hp.p.tt.tsplsc..........h...phhh.............phhp........h+ptlhptltthhcc......................................................................................................................	0	53	104	135
+11842	PF12009	Telomerase_RBD		Telomerase ribonucleoprotein complex - RNA binding domain	Mistry J, Gavin OL	anon	pdb_2r4g	Domain	Telomeres in most organisms are comprised of tandem simple sequence repeats [1]. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition [1]. One major influence on telomere length is the enzyme telomerase [1]. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme [1]. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets [2]. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA [2].	21.20	21.20	22.20	22.60	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.70	0.71	-4.25	54	413	2009-07-08 09:22:28	2009-07-08 10:22:28	3	9	237	6	156	402	1	125.40	26	14.05	CHANGED	ppVstFlhshlpp....ll........P.ph.aG.........spcNppthh.pplppalph.t+aEphslpclhptl+lschp.WLtttttsppht.......................chpppppllt.......palhWlhp.pllhsll+shFYlTE....p..ttppsclhYaR+slWpplsp.slsp..htp	...................................pVhtFlhthlpp....ll..............P.ph.hG..........................sp.pN.pphhh.pplppalpl.t+atphslppl.hpth+l..p.........sht.WLp.t.th..tt.p.h.............................................................................phphpppllt.........palhW.lhssh.ll.LlpshFYlTE....s..thp+p..plhaaR+slWpcL.p.tltph..t..........................	2	52	83	123
+11843	PF12010	DUF3502		Domain of unknown function (DUF3502)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3448 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with Pfam:PF01547.	47.30	47.30	47.90	47.30	47.00	46.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.51	0.71	-4.19	18	679	2009-09-11 16:21:44	2009-07-08 11:40:33	3	5	494	0	91	398	5	134.70	42	27.71	CHANGED	GIEGpHY-+lscs................pI+hhss..psY.shss.Wsh..GNhhl...phshEs-s..D+W-pacchsppApsSPhLGFpFDsssVcopIuulsNVhpcapssLhTGoVD.P-ctlschhpKLcsAG.lDKVhcEhQ+QLD-a.ptpsp	.....................G.EGcpaEKlssp................+l+....lL.....c....u...h...p..s..s.......h.....c.h.u.u....Wst.....GNshI....l.Yhp...Es...s...s-....p...plcp.p.c....c......h.tc....A.+..p.S.P..hLG.FhFsocsVKoEIoulsNlhppatsulsTGTV...D..P-cs...lPcLhcKLKsuG..h-KVhpEhQKQhDEa.lpsp........	0	56	77	82
+11844	PF12011	DUF3503		Domain of unknown function (DUF3503)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2686 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in viruses. This domain is about 170 amino acids in length. This domain is found associated with Pfam:PF00271.	25.00	25.00	54.30	52.00	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.18	0.71	-4.53	12	81	2009-07-08 10:43:55	2009-07-08 11:43:55	3	4	41	0	0	79	0	166.00	60	25.25	CHANGED	M-NcLPsIFaFPNCVslFPacYSQpEh-cMppp-+ctFShAVFPlIKHRWpcuallhc.spsaKLssE.pp.ph..p+ls.ssl.s.....Psplshph+pYhhss.h+IoFECYSYLpCpphs.clpshs-...llRGLlEGGNpLpIFSssh.....G.phssoIGIhGNspPFsKlPLtSLpP	.......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNMSc....sER-uFSLAVFPVIKHRWHNAHVVKH.KGIYKVSsE..A.RG..+KVSPPSLGK......Ps+INLouKQY.IYSE.+sISFECYSFLKCITNs..EINSFDEY..ILRGLLEAGNuLQIFSNSV.....G.KRsDTIGVLGNKYPFSKIPLASLTP................	0	0	0	0
+11845	PF12012	DUF3504		Domain of unknown function (DUF3504)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2196 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.	29.70	29.70	29.70	30.20	29.60	29.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.91	0.71	-4.49	23	439	2012-10-02 14:09:14	2009-07-08 11:46:23	3	21	79	0	263	356	1	158.10	35	17.41	CHANGED	uhlh.Scl-E-hLWps+p.LGspSPhsLLpoLhaasT...KYFsl.+Tl-pHtcLuFuplh+ps+pt.........tsc.shlRahssp.t.pstpsh...ucppc...................ptt.h.hp.h-ssssPh+CPVpha-hYL.Kps..slcptpssFYLpPc+sssssuslWYsppslucpsLpphls+lhhs	.......................................................................lh.S+l-E-hLWcs.KQ.LGsaSPhsLLsTLhaFNT...KaFsL.+Ts-pHhcLuFuplh+pp+p....................tsc.shlRah...s.s.h....ttp.s..t..p..t........scpp+...................ppt.h...hE.hENsp.NPh..RCPV+.....la-hY.LuK.sP..psl+pRs..DsFYLpP......E...p.....s.s...........ss........s.S.....P........l....WYospslscspLppMLsRlhh..........................	0	90	109	169
+11846	PF12013	DUF3505		Protein of unknown function (DUF3505)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2856 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 247 to 1018 amino acids in length. This region contains two segments that are likely to be C2H2 zinc binding domains.	26.60	26.60	26.60	26.60	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-10.86	0.72	-3.82	16	197	2009-09-11 05:54:46	2009-07-08 11:50:44	3	15	33	0	172	211	0	103.00	23	12.06	CHANGED	pLFha.spapVhICRp..CcauVhP..pplpsHL+t+H+ph........psttt.....plppsl.........psas..tpcspssphPs.s.s.PlPtLPla.sGhtC..s.spCpYlspshpsh+cHhpppHs	.........................................h..ph.llICpp..Cpaulhs.....splpsHLpp.cH+th.............tt.tp..tltptl..............ppht......l..htss....p...s...l....p...h..Ps....t.stPlstL..shh....sG.ht.C.................stC.ta.hstshpshppHhpppH...................	0	42	80	167
+11847	PF12014	DUF3506		Domain of unknown function (DUF3506)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3293 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 131 to 148 amino acids in length. This domain has a conserved KLTGD sequence motif.	39.70	39.70	41.00	39.80	38.80	39.00	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.79	0.71	-4.35	12	152	2009-07-08 10:53:22	2009-07-08 11:53:22	3	10	108	0	101	146	1	130.20	41	25.46	CHANGED	pslosaspl-...hoPoppcPapGlalGsausaGsEhlhLpp+.Gp.ptscssppp.................psh.hhthlEAlKLTGDPNVPtGploFhAc.IGcpshlp..cc.sha....Gs..thh+upG+lAs.GF+sscal-u-Llhlssc	...................................p.t.otaspl....hsssspcPapGlaVGsausaGsEhl.lp......p+.sph.......tps.................................................................ssh.ahthlEAlKLTGDssVPtGploFhAc....lGp....s.uhlp..pc.shas.........Gs...thhKupG+lApsGF..+ss+al-ucLlllssc...................	0	23	58	84
+11848	PF12015	DUF3507		Domain of unknown function (DUF3507)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3482 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 180 amino acids in length. This domain has a conserved ENL sequence motif.	25.00	25.00	25.30	25.80	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.04	0.71	-4.78	10	67	2009-07-08 10:56:31	2009-07-08 11:56:31	3	2	65	0	45	66	0	169.00	29	11.77	CHANGED	lsslph.htols.sphhstps.hp.tpp.ppcWspl...FspuslFpGhD-llaGphlshVYccscos+lssh.lsKaGlosacNlslsspSRFaPAsENLpPcYpcSsVRRsLAlohLKp.......YsLLsssshphl.sphs...saDpTaAG-LAsshpLlss.psPp-hGppLlphGLLQs..+slpShllDVV	.............................h......................................tphshapu.Dsll......aG.hl.....sss.pssp.o.....s+lpuhllsphGhpsasplslSssStaYsAlpNLs.ccQpspVp+uLAVshLKh.........aspL.ssst...hppl.....t....s.........phs.....ptaDEhaAG-LAspM.phlps.t.........s.........chspplh..GhhQp..+h.l.sh.lDVl.......................	0	7	20	39
+11849	PF12016	Stonin2_N		Stonin 2	Mistry J, Gavin OL	anon	pdb_2jxc	Family	Stonin 2 is involved in clathrin mediated endocytosis [1]. It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs) [1]. In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling [1].	96.90	96.90	125.00	124.30	96.60	96.30	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.26	0.70	-5.29	2	50	2009-07-08 10:57:23	2009-07-08 11:57:23	3	3	30	1	27	46	0	287.10	77	35.28	CHANGED	MTTLDHVIATHQSEWVSFsEEP.FPs..pGGTEEHhPGLSSSs-pSESSSGENHVVDtGSQDhSHSEQDDSSEKMGLISEAASPPGSP.QPsPDLASAISNWVQFEDDTPWuSTSPPHp...ETALsLTMPCWTCPSFDSLtRCPLTSESSWTTHSEDTSSPShusSYTDLQLINsEEQsSGpASGsDSTDNSSSLQEDEEVEMEAISW.AuSPAMNGHP.APPVToARFPSWVTF-DNEVuCP.PPVsSPhKPNTPsuAoshPDVPaNShGSF.KRDRPKSTLMNhsKVQKLDISSLNRsPSVhEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQER	................MTTLDHVIATHQSEWVSFsEEP.FPs.SpGGTEEHLPuLSSSsDpSESSSGENHsVDGGSQDhSHSEQDDSSEKhGLISEAAS.PPGSP.QPsPDLASAISsWVQFEDDTPWuSTSPP.Hp.s.E.TALsLThPCWTCPSFsSLtRCPLTSESSWTTHSEDTSSPShusSYTDLQLIsAEEQsSGpASGADS.TDNSSSLQEDEEVEMEAISWQASSPAMNGHP.AsPVTSARFPSWVTFDDNEVSCPLP.PlTSPLKPNTPPsASVhPDVPYNShGSFKKR-RPKSTLMNFSKVQKLDISSLN+s.PSloEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQER....	0	1	2	6
+11850	PF12017	Tnp_P_element	Transposase_37;	Transposase protein	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3357 (release 23.0)	Family	Protein in this family are transposases found in insects. This region is about 230 amino acids in length and is found associated with Pfam:PF05485.	34.00	34.00	34.30	34.10	33.30	33.90	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.61	0.70	-5.13	6	118	2009-07-08 11:00:53	2009-07-08 12:00:53	3	6	45	0	59	139	0	205.90	34	36.85	CHANGED	uNuSTQTEssllsp....ENcoLRpKIRsLEpEl+pLRQQLE-uppLEpSLspIFT-TQIKILKsGGKRusFNSsDhSsAICLHTAGPRAYNHLY+KGFPLPSRsTLYRWLSDV-IpTGsLDVVIDLM-N--MD-ADKLCVLAFDEMKVAAAFEYDSSADllYEPSsYVQLAhVRGLKKSWKQPVFFDFsTtMDsDTLpsIIpKLH++GYsVVAIVSDLGsGNQ+LWpELGISEp.K	..............................................................t....p.hcp....plp.p......hchchp....pLc...p....pl.....c.p...........p....p...lc.....c....sL...pph......Fop.s..Q.l.+..h...L.......p..ss.s...p.+..s.p.ass--hutAlsL.+...s.s.uP+uYpaLh.c.+.saPLP....SppTLh+a.lsslplp.G.hh..c.s.llcl....h....c..s..c...t..h...s...ptD+..lC....lLsaDEMp......lssth-YD...............s..........s.......t..........D.....h........l............h...........c.........s....u...sa.....lt.....ls...hlRGlpcsWKQPl...aa.....sF...s.o...t.Ms....s..ssL....p....p....I....l....p....+....LpphGh.VlAlVSDhGssN.phhpcLGl...................................................	0	23	28	57
+11851	PF12018	DUF3508		Domain of unknown function (DUF3508)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3527 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 280 amino acids in length.  This domain has two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704.	25.70	25.70	26.20	26.10	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.70	0.70	-5.42	10	142	2009-07-08 11:03:06	2009-07-08 12:03:06	3	5	95	0	95	138	2	241.40	28	45.54	CHANGED	ulLccslPsosp+I-ppLpsspctshcYTulLEchst....ssthspcl...h..LK-ALYNlRQaEsFLphlLoDlhssApp......V.EhhppchtuplEpLKpsl+sKoAVPTsQVF.....PhFsALupLWsuLp-EphLlssLsNLhspLpsFlssacLhhP..tpsh.slLsstsV+oDtsRhcp.........shtcclslu-apspEa...LhPEsTAsFpcL.lQYpGFCuaTlss+DGLLLPGNPulGlLKa+-KaYsFuo+cAAh.cFupc.P-pYIstltEpA++ssELIpLLcLcQpFpol	............................................................s..lp.s...h.ptlptplp...tstp.shpa.sullcphht...............sshhttph...h.....hp-tLhphRQaphalphlhpsl.thtpp.......l.p.hhpphtsthpplp............s..........l..........p...........+s..........ulsotpVa..............PhFhtLuplWs.shpc.Eh.hls.lsplhtplpsh..ht.s..pt.hhs....t.h.h.thL.p.....th.lps.c..p.chpc..................................p..h.....hphs-h...pp....ph.........hhs..ps...sssh...p..c...h..l.papGFCuhohstp....s.G...LL......l...........PGs............P...sl..Gllpa....pp....+hYsFsoc-ush.pFupp.P-palthlhchs+ppscLlpLlpLppph...h...................................	0	37	49	74
+11852	PF12019	GspH		Type II transport protein GspH	Mistry J, Gavin OL	anon	pdb_2qv8	Domain	GspH is involved in bacterial type II export systems [1]. Like all pilins, GspH has an N terminus alpha helix [1]. This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands [1]. GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins) [1].  The function and localisation of minor pseudo-pilins are still to be fully unraveled [1]. It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.61	0.71	-3.93	214	1652	2009-07-08 11:47:00	2009-07-08 12:47:00	3	3	953	3	399	1257	143	122.00	15	68.53	CHANGED	ssppLtsslphARscAlp..p.spslslsstss..stth................tt...Wssuhhlhht..tssstt....t...........................thssshphshs...........................................ssplpF..s.ssGhs..........................tshs..ht.......hsssspspt..............l.hl.ss.....sG	.................ApclhstlphA+scAlh..p.s...ps.lslphs...ss..uhph..........................tsp...W..pss.htshhs....ssstt..........tth.h........................h.ssssththp.t.....................................................sspltF..p..spG.s................................sshs....lp.........htssstt.....................th...........................................................................................	0	100	222	319
+11853	PF12020	TAFA		TAFA family	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3899 (release 23.0)	Family	This family of secreted proteins are brain specific and thought to be chemokines [1].  These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.	25.00	25.00	25.90	41.70	16.90	16.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.24	0.72	-3.88	3	241	2009-07-08 13:15:59	2009-07-08 14:15:59	3	2	38	0	140	188	0	84.20	68	71.79	CHANGED	+sGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGQVAGTTRA+PSCVDASIVlQKWWCcMEPCLEGEECKVLPDpSGWSCSSGNKVKTTRV	..............sGTCEVlAhHRCCNKNRIEERSQTVKCSChPGQVAGTTRApPSCVD..............A.SIVhpKWWCcMpPCL-GE-CKlLPDhoGWoCoo.G.N.KlKTT+l.....................	0	5	20	68
+11854	PF12021	DUF3509		Protein of unknown function (DUF3509)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2180 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 92 to 110 amino acids in length. This protein has two completely conserved residues (G and R) that may be functionally important.	25.00	25.00	25.20	25.00	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.93	0.72	-4.24	19	201	2009-07-08 13:16:45	2009-07-08 14:16:45	3	1	60	0	39	130	2	93.10	31	94.84	CHANGED	cph.phls-sFss.YpVshu..csDGullLTLpsssG.hlh+RhlotsQhs-tppLppllsul+R-LAlctGchs.plluthppt..............schts..........httt	.....p..phls-sFss.YpVshp.sRsDGulLLTLpsppG..hlhcRslossQLs-.ppLppllpulRR-LAlptGch..plluthppt...........tp.........h....................	0	2	6	26
+11855	PF12022	DUF3510		Domain of unknown function (DUF3510)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2857 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 130 amino acids in length. This domain is found associated with Pfam:PF06148.	29.10	29.10	29.70	30.10	23.90	28.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.45	0.71	-4.02	21	198	2009-07-08 13:21:08	2009-07-08 14:21:08	3	8	161	0	133	191	2	126.70	34	17.21	CHANGED	lpplhppsh.ptLcplpslsphYRhTN+psPop......sSsYVssllpPLpsatptt......thlspthhcchlpcllsplocpYhptss-llsoVcKpp-SLpRl+ptptpsuss...............shsD-DKI+hQLhlDl	..............................ppLscpCh.p.L+p.spslPphYR.tTNKp..lPop.............sSsYVssh..LcPLpp.hhstp............................pshltpthh....pphlptslspsTccYhphls-VLsoV+KhEESL..........+..RLKpspppssussss................................sssuhSD-..DKIRlQLhLDV.............................	0	56	76	109
+11856	PF12023	DUF3511		Domain of unknown function (DUF3511)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3314 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain has two completely conserved residues (Y and K) that may be functionally important.	25.00	25.00	33.70	32.60	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.32	0.72	-4.64	14	157	2009-07-08 13:24:58	2009-07-08 14:24:58	3	4	20	0	99	137	0	46.60	52	35.52	CHANGED	hthsDPEhKR+RRVAuYKsYuVEGKlKuSlR+ua+WIKs+ho....p........llcG	.......hsDPEh+R++RVAuYKsYuVEGKlKuSlR+uF+WIKs+ho....plhaG.................	0	12	58	82
+11857	PF12024	DUF3512		Domain of unknown function (DUF3512)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3525 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with Pfam:PF00439.	33.70	33.70	37.20	34.40	28.00	30.30	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.52	0.70	-5.08	13	193	2009-09-11 13:40:57	2009-07-08 14:46:16	3	5	85	0	107	170	0	213.90	36	37.66	CHANGED	ppKc.s....+p.h+ht........cscspspshssshstE+lLtplcpsucEAps+ls++hssuKhGFLR+psDGoTohslltss-sputEt..sp+sVsLGshsGKLpsGsssLtGFKED+RNKVTsVs.LsYGsaoSaAPpaDSsFuslup--oDLlYuTYG--oGspsAhSlp-FlcssspaupthscsLLDhlTsG-HS+oltplppppppp.p.sc......................pspstttppusshlDatuL+oloslGlDsphL	.........................................................p.p....+p...phh........ps.hptp.hsssh...E+..t.lcphscE.uts+ls.phhssuphta.++psDGohh.hsllp..ss-s.st-..........thpsVcLu.hou+L.s..Gh..s.oL...G.FK..-D+RN+VT...lp.h..YusaoSaAPpaDSsFuslsp--o-LlYSsYG-.......-oulps.uhS..lpEFltss..ssYsht.hsDsLLD.lTsG-HS+ol.plcppp..s.t...c.................................pht.s.h....tss...s..chhuhcshs.shulshphh.......................................................	0	26	34	66
+11858	PF12025	Phage_C		Phage protein C	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3530 (release 23.0)	Family	This family of phage proteins is functionally uncharacterised. Proteins in this family are typically between 68 to 86 amino acids in length.	25.00	25.00	61.90	61.70	24.50	21.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.26	0.72	-4.02	3	67	2009-07-08 13:51:34	2009-07-08 14:51:34	3	1	54	0	0	34	0	65.40	71	83.07	CHANGED	sLSL+sSRSSYFATFRHQLslLoKTD.ALDEEKWLNMLGsLLKDWFRYE-HFVHG+cSLlDILKERGLL	sLSL+sSRSSYFATFRHQLslLoKTD.ALDEEKWLNMLGshlKDWFRYEsHFVHG+cSLlDILKERGLL	0	0	0	0
+11859	PF12026	DUF3513		Domain of unknown function (DUF3513)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3541 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 192 to 218 amino acids in length. This domain is found associated with Pfam:PF00018, Pfam:PF08824. This domain has a conserved QPP sequence motif.	25.00	25.00	28.20	28.20	21.60	20.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.38	0.70	-4.78	14	329	2009-09-16 12:09:40	2009-07-08 15:01:52	3	10	100	3	138	289	0	197.70	44	27.92	CHANGED	ssst.p.phsttthhEDYDYVHLpup-php+pptplhc+t..............................................t.pp.EpLcppstcstpps...............oPsp.hs.........lsspD+pLLhaYucQCptahssLhpAlsAFhuSlsssQPP+lFlsHuKhVIluAHKLVhlGDTLsRpspst-lRscVhpsSstLCphLKslVLuTKsAALpYPSsuAlp-MsscVpcLsppsppF+shLt	....................................................................................s......p.sttshh-DYDYV+LpG..+-c..hp+ppcplh-pt.sh.....t.......................................phppachLcp.phs.p.s.h-ps..h.tt...........................................pPspshs..............sssluspD+QLLhF....Yh..-QCcsahssLhsAlDAFao.........sVussQPP+...........IFVAHSKFVILSAHKLVFIGDTLsRpsput...DlRscVhptSshLC-hL+slVhsTKtAALpYPSssAhQ-MVcpVp-LuppsppF+psL.h...........	0	22	34	72
+11860	PF12027	DUF3514		Protein of unknown function (DUF3514)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3570 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 368 to 823 amino acids in length.	25.00	25.00	27.30	33.70	16.20	20.30	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.71	0.70	-5.14	26	49	2009-07-08 14:03:17	2009-07-08 15:03:17	3	2	7	0	32	48	0	222.90	18	45.07	CHANGED	lhh+s-l.shLpph.ssphchsshllKluhlhp.hhhhhst.ph...sptlhhs.t.phhc.phlD.lLhclhssspss......thshpthhphhhshptpph.spshthasssF..appllslhpcll.ts+hsssh......h...pllshlllSCslplGsMY......t.hthhsptsss.tp......................ptthhshhshplhpshtahYssssp...slphl..sslshPphllchCSpph.hsplpppltpsph..sFslhhpclspplsphlspps	......................hhp.ph.phl.p..hpp.phthhllKhshl.p.hh.hhsh.th...sp.lhhs.t...h-..hl-.lLhplhsh.pps.......h.hphhhthhhshhtpth..tshthhsssF......Ypplhplhtplh..h+.sps.......h....plhshlllussh.lGtha........hhhhtp.tht.tt..........................t.h.hshhshplhhshhahYssssp.....l.hl..sshshPthllphsSpth.hs.lpp.htpsph..sFslhhpslspplsphh.p........	0	9	9	9
+11861	PF12028	DUF3515		Protein of unknown function (DUF3515)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3590 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.	25.00	25.00	37.50	32.40	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.28	0.71	-5.00	26	415	2009-07-08 14:05:35	2009-07-08 15:05:35	3	2	352	0	114	292	45	149.20	30	92.10	CHANGED	tssllussslsslLssAusht.....tslulushPAPpAssst.CpsLhssLPppLushpRuthh-PsstGsAAW...Gss.tsllLRCGl-p.Psp.hsssush.sV..cs...VpWhtsssts...sus.........................so.has.VsRsshVtlTls.sss.......Gs.oshpsLoslhsss......hthtshpsss	..........................................................h.........hhhhhhhsh..........................................s..sh.s.sss....ust............Assst...Ctslh..ssLPpp.l.....u.....s....ht+....t...s..hh...ps...s...ss.usA.......uW.....Gss...sl.l.LRCGV-p.Pu.....t....h.........p.........s..s.......ush.ps.........V.........ss...........VsWFp.psss.....G..............................................ts.hao.lsRtshVtlTlP..ss.t.......us..tshss.Ls-lhsshhths..t..........................	0	34	87	110
+11862	PF12029	DUF3516		Domain of unknown function (DUF3516)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3601 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with Pfam:PF00270, Pfam:PF00271.	25.00	25.00	31.60	30.80	21.60	20.50	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.60	0.70	-5.68	23	417	2009-07-08 14:07:34	2009-07-08 15:07:34	3	5	397	0	120	382	22	445.70	48	54.35	CHANGED	APEH.lENt+thAKA....GDDP...KKpRKlhRKKsPE.GaVsWucsTF-RLlpAcPEsLsSpFcVopuMLLNVl..........uRsGDsasuh++LLp-NH-sRspQp+hl+RAltlaRuLlsAGVVEc.l..-pPD....spGR.psRLTlDLQtDFALNQPLSPFALAAL.ELLDsESsoYALDVlSVlESTL-DPRQVLhAQQcpARGEAlAtMKA-GlEY-ERMtlLEEVTaPKPLtElLcsAa-hYRpuHPWlsDapLuPKSVVRDMaERAMTFs-aVspYGLuRSEGlVLRYLuDAY+AL+pTVP--tRTEELpDlI-WLGELVRQVDSSLLDEWEpLssPss...stssp........shsspsPpslTANpRAF+VhVRNAhFRRVELsAtcch.stLupLDs......tsG....hssssWp-AL-sYa-EH-cIGTGPDARGPpLhhl-cs..........s......................c......hWpVRQllcDPsGDHDWuIsApVDLsASDEAGcsVlcssslsp	..................................APEH.IENtKAlAKA........GDDP.....KKh+K...l....tRKKsPE.GFVsWuEpTFp+LlpupPEsLpu+h+lTcuMLLNll............sRs....G.....D...shtshc+Llcsspp......shtppp+hhcRAlpIacoLlsusVVc+l......-pP.s...........ssG.R.....phtlsh-LpcDFALNQPLSsFALAAl.-LL......D.....P......-S......s.................o......Y..ALDVlSVlEATL-cP+plLhAQp+pARGEAlAtMKA-Gl-Y-ERMttL--loaP+PLc-hLpsAF-hYtpupPWls-htLpPKSVVRDMhE+AMTFs-alupYtlsRSEGlVLRYLoDAYRuLcpTVP-st+o.-ELpDlIpWLGElVRplDSSLlDEWEpLssPts........ttspp.........................spsspslTuNpRAFpVhVRNAMFR+Vp.LhAh-ch.-tLGt...L-s.......................thu...........hsss.sWp-sLssYaDEa..--lssGs-ARuPtLhhl.-pp................s.....................................c...hWpVRQI..lcDPsG-HDWuIsApVDLsu.o.D-sGcsVlcshsh.s..................................	0	42	88	112
+11863	PF12030	DUF3517		Domain of unknown function (DUF3517)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3933 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 340 amino acids in length. This domain is found associated with Pfam:PF00443.	25.00	25.00	39.90	27.20	23.30	22.90	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.04	0.70	-5.89	7	66	2009-07-08 14:28:27	2009-07-08 15:28:27	3	3	65	0	54	70	0	333.30	29	14.32	CHANGED	DYFEhLh.LAsFGshEsthlLppGFLLKCLEIlWLD+EDSKRL+RQYhsYh+LlEKGR+FSHRKLh-LLuhLLs+IDhTssPos-DcR+sLPsG+aoLThoEsshlRPL.GRspELslL+KlLpQ.ssPpAsRsIVulhlDAEPEAGLhDPICKVLE-GLRluP.AcLCAPFLEATLIFCpRSPDc-RIVuLIDaVAKGV-SINDSGG+EHLAFFTulhssRNERLuL-EsWFLSpllD+IPDWAPTLLhaPDRsVRNMTh-hL+pILFosEAp-hs..-DaQsRau-lAKELV+ASl-+LRKsaLssPGssVEs+sl..Eol+sVI-HCLsoYF.sDSE-DQ-	......................................................................................................DYFthlltlAphGthEsthlLpc.GFLh+.sL.cllhhD..pcs......o.p...cLpc.pYssh.h+.ll..p...K...sRphS.....atp.LhpLLshLlsp....l....D....h....sh..s.........P....s......s....s....s..pp.....c.....p....h....t.....s.....s..+...a..........sl...........Ths..E.spll.p.s.h.s+p.p..s.h.hhlcKlLp.ppsstso+....pIlshllst..p...sph..sL..t..-sl.h+sLccGlpspP..upL.ssPFLc.A..sLlFCptusshsplpsLIcalscsscS...lss...u......s......GcpaLsFapslh.ss.c.Npp.h..ttsc..t.hhhstl.l-plPcWAPsLLtasDc...sVRssT.caLpplLF...........s........t.....p.h......p....-.h...s...-.....-.......h......pp......h..h....pc....h....u+pL......upsClp.....hL+csals..s.s...s..p..l.pspsh.pslphVlppChthYF.sptp.......................................................................	0	7	24	41
+11864	PF12031	DUF3518		Domain of unknown function (DUF3518)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3830 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 260 amino acids in length. This domain is found associated with Pfam:PF01388.	40.20	40.20	58.30	43.20	29.50	23.90	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.77	0.70	-5.58	6	191	2009-09-14 14:01:10	2009-07-08 15:30:20	3	4	82	0	96	173	0	241.10	64	14.63	CHANGED	DSLAKRCICVSNIlRuLSFVPGNDsEMu+HPGLlLILGKLlLLHHEHPcRpptPtTYp+EE-c-pGluCS....K-EWWWDCLpsLRENsLVTLANISGQLDLSsYsEoICL..PlLDGLLHWhVCPSAEAQDPFPTsuPsSsLSPQRLVLEsLCKLSIpDsNVDLlLATPPFSR.EKLassLVRalGsRKs.VCREMuVsLLSNLAQGDstAARAlAlQKusIGsLluFLEDulshAQaQQStHSLhH.Mt..sPsh-PsSlDMM	.......................DSLA+RClCVSNIlRSLSFVPGNDhEMSKHPGLlLILGKL................lLLH.HcH.....PE....RK...pAP...TY...E.KE..E...-....p..DpGVuCs.........................KsEWW...W.DCLEhLRENTLVTLANISGQLDLSsYs.ESICLPlLDGLLHWhVCPSAEAQDPFPT..lGPNus..LSPQRLVLETLsKLSIQDNNVDLILATPPFS..R..EKLYuoLVRaluDRKssVCREMulsLLuNLAQGDoLAARA.IAVQKGS.IGNLluFLEDulshsQaQQSQpuLhH.MQ..sPshEPsSVDMM..........................	0	25	33	60
+11865	PF12032	CLIP		Regulatory CLIP domain of proteinases	Mistry J, Gavin OL	anon	pdb_2ike	Domain	CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively. [1] [2]	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.19	0.72	-3.87	120	622	2009-07-08 14:42:14	2009-07-08 15:42:14	3	13	68	4	294	670	0	53.10	30	15.22	CHANGED	CpsP..ssp.sGpClslppCpslhpl.hpp.....p.hsspctpaLcp..upC..Gh.....tss.pshVCC	.............ChsP..s..sp.sGpCltlppCs..lhpl..lpp.....p.hss..pptpaLpp...upC....Gh...............tss.pshVCC..................	0	55	100	249
+11866	PF12033	DUF3519		Protein of unknown function (DUF3519)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2444 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 117 to 1154 amino acids in length. This protein has a single completely conserved residue Q that may be functionally important.	27.50	27.50	28.20	27.70	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.53	0.72	-3.85	10	158	2009-09-11 06:57:10	2009-07-08 16:12:16	3	3	48	0	3	164	0	96.40	26	22.41	CHANGED	ll-phsKl-cpst.hAhcapN....l+lslpcppsspclhsaa..puacchh-ss.hhpsSsh.......hsttphpshsuscsNPTsKPLTSQEsL....LKsoENLNEsTsEsspLSP	..........................llcph..+.h.cp.tht.hAhchtN.....h+l.s.lpsphssppL.saa..puac....hp.-sphhhphpsh..........htttt.hps..hs.scs..NsTpKsLpoQEsL.........hpppct.tp.............................................	0	2	3	3
+11867	PF12034	DUF3520		Domain of unknown function (DUF3520)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3604 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 180 amino acids in length. This domain is found associated with Pfam:PF00092.	25.00	25.00	34.10	31.40	19.50	17.70	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.16	0.71	-4.16	49	418	2009-07-08 15:16:07	2009-07-08 16:16:07	3	13	396	0	115	369	71	179.40	45	30.57	CHANGED	uTLhTIAKDVKlQVEFNPApVucYRLIGYENRhLscEDFsNDpVDAGEIGAGHsVTALYElsssusts........h-sLRYtt.......stts..........sstssELAhl+lRYKtP....suspSpLlphsl...t.tsshspuSs-h+F..AuAVAuFGphL.+sucah.......sshsasplh.sLApsutGp..DthG.........YR.sEFlpLlc...hApuLp	.............................tTLhTlAKDVKhQlEFNPuhVsEYRLIGYEsRtLpsEDFN.NDpVDAG-IGAG+pVTALYEls.sGppup.........lDcLRYt..................sptss.........sspssELAalKlRaKtP.............pup..cSpLl-.hPl......s.ssh.spsS.cDhRFuAAVAuaGQhL.RuScah........sshoasplhphAppupGp..DstG.........YR...uEFl.cLlchAcsh.s..........................................	0	48	77	96
+11868	PF12035	DUF3521		Protein of unknown function (DUF3521)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3612 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 42 to 74 amino acids in length.	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.57	0.72	-4.11	23	1098	2009-09-11 15:50:18	2009-07-08 16:24:58	3	4	252	0	1	353	0	30.30	39	57.64	CHANGED	MPDAhphuu..hpthspllsh...ttaVGphRRs+php.+	...........MPDAhhhsu...hpsh...p...phhp.......ht.hRps+thp.c......	0	0	0	0
+11869	PF12036	DUF3522		Protein of unknown function (DUF3522)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3665 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length.	25.00	25.00	27.10	26.90	22.40	24.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.25	0.71	-4.50	24	294	2009-07-08 15:30:14	2009-07-08 16:30:14	3	4	111	0	167	260	2	162.00	32	30.55	CHANGED	.ttthhtslhhslSslshlPslhhsh++pahhEuslhhFshhhShhYHuC-shss.hh.....hshhpachLp.hshluuhhuhaVplhshsthsp.hcpslphhshhhhhlhttts.hshh.hlsPlhhulhhhlstahhc.t+tpphhstphh...........................hhhhhhssulhhhhhuLs.....-spDsYthhHo..hWHh	..........................h....hhtsLlLsLSNLhFlPslhlul+ppa.hhE...uslYhaoMhFSshYHACD.tss..h..........hChhpachL......p....a......hshh...uohhuhaVol.h..shup..hpthhctshhhhshhhhuhhhthst.h...s.hhshhhPh.hhuhhlhhs..t......ahhc..hc..p.+phassphh..............................................................................................................................hhhhhlhs.Ghhhshhu.l.h...hp..sp.....-sYhhhHS..hWHh...........................................	0	45	67	110
+11870	PF12037	DUF3523		Domain of unknown function (DUF3523)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3746 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 257 to 277 amino acids in length. This domain is found associated with Pfam:PF00004. This domain has a conserved LER sequence motif.	25.00	25.00	29.40	29.30	23.30	23.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.84	0.70	-5.42	14	270	2009-07-08 15:33:07	2009-07-08 16:33:07	3	5	136	0	167	233	5	216.40	41	43.44	CHANGED	PsPPussussssssp.............t.tshsusFDPoALERuAKAL+pL-pSsaA+cAhELhKhQEpT+QtEhpschcchpAthuphpsE+tRl-t-E+RKslpppsppcptpupYcDcLuRcRhpccLppQcppNpE.L+pQEEush+QEthR+pT............ccEtcLc+cNhht+lcAEscuRh+tcRcNcDlphchl+.+usEcRcThlEuIpTshuhlGsGhpshLoDpsKlshsVGGlThLAhGlYTs+pGstVshpalEppLG+PSLlR	..........................s............................t.t.t..tFDspuLERuAcAh+plppS.pA..+c.............shpl.phQEtTh.QhE.pschpchcsthtphc...-ph+hptEEc............RKshpppspppptpApYpDpLuRpRhp.............c...........phtt.............Qphh.pp-.l+hQE.ESs.+QEthR+tT......................hccchcLc+cs.hh+hpAEscu+A+tpRpNtDl.hcpl..+h+AtEcRpThl-uIpTshsh.hGt............GhpshloDhsK.lhssVu.GlThLAsGlYou+pustVstpalEttLG+PSLVR..........................	0	62	89	134
+11871	PF12038	DUF3524		Domain of unknown function (DUF3524)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3749 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is about 170 amino acids in length. This domain is found associated with Pfam:PF00534. This domain has two conserved sequence motifs: HENQ and FNS. This domain has a single completely conserved residue S that may be functionally important.	25.00	25.00	25.20	25.10	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.07	0.71	-4.70	31	155	2009-07-08 15:36:23	2009-07-08 16:36:23	3	6	115	0	73	154	105	154.80	47	44.42	CHANGED	M+ILlL-sahuGSHppatctLhpp...pa-hplloL.PuRtW+WRhRGuAloau...pp.hhtpppa...DlllAToMlDLAslhuLpP.pLup....lPtllYFHENQhsYPhss......spp+chpashlNlhSALAADtVlFNSsaN+cSFLsulpshLc+hPDhts.tshlcpIttKupVLsssl	....................MpILllEsFaGGSH+plh-hLtcpl....t....-hslhTL.PA++W+WRhRsuALhFu....pp..lshsppa......clLhAoShLsLspLhuLpP.cL.up....hcpllYFHENQLsYPVpc......spcRDhpauasplhSsLsADhVlFNStFNh-SFLsulspFh+hhPDa+P..psltphIcsKspVlahPl..................................	0	26	37	53
+11872	PF12039	DUF3525		Protein of unknown function (DUF3525)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3833 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in viruses. Proteins in this family are about 360 amino acids in length.	25.00	25.00	334.60	132.90	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.57	0.70	-5.98	2	191	2009-07-08 16:05:37	2009-07-08 17:05:37	3	4	4	0	0	133	0	144.50	43	73.73	CHANGED	LlFEPVTRGKaTF.YPFGHWCLRDTNSMIlYEG+FVs.ctTSlGs.FKLoKShRPl+sGtshHLVPFHlQKLLDSMD-cs.PYSAsHNCTTVILcuIMYRSslGFlFAYulSWAVYhVLRPPQhAATsYpWhaPERoWDpS+hYphLGFAAGGTlPMEhlDpE........P.E-c.S................................DsuRo...s-ND.................................................cQ+cs-h.pEWWhSpDSlcsVpNDlhYhLSFL+sTsIPE-l+L-lVELsYsQhscDEccRIPEP.GT+ILsMPsW+PsNWA+LIDETHRVLSQFopYsPRlLNEhssWL+GLupNLYRVsEPIL.LLlRAMRAAhoVSpRAsRSlYpChCHWLDVMYGGSAPpRlKTVWGLTGhIsSGMTSQ	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+11873	PF12040	DUF3526		Domain of unknown function (DUF3526)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3851 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 149 to 170 amino acids in length. This domain has a single completely conserved residue P that may be functionally important.	25.00	25.00	35.80	34.00	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.69	0.71	-4.08	38	152	2012-10-03 10:13:34	2009-07-08 17:13:32	3	4	74	0	62	180	55	155.60	23	34.11	CHANGED	oph-hshsl+...csh......csssDhthpthtpphlppas.ptscs......LPh.saphhh...hhtscphssphhsphhcphhpthtpQpplschhuhlSPslulpphspslAGTDhtpahcFhppsEpa+tphtphhst.................stshpptphssspaptlPpFpap.	...............................................th-hshthc...csl......pss.D..htphhpphhtpas.ptscs......Lss..sachhh...hhttcphssphhsthstphtpthtpQptlspthuhluPslAlpph.hpLAuTDhtsphpF.pps-ta+tpltphh...................................................sthhpcpthss.scapplPpFpap............................................	0	24	41	48
+11874	PF12041	DELLA		Transcriptional regulator DELLA protein N terminal	Mistry J, Gavin OL	anon	pdb_2zsh	Domain	Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins. [1]	20.70	20.70	20.70	26.70	20.20	18.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.64	0.72	-4.32	20	463	2009-07-09 08:13:55	2009-07-09 09:13:55	3	4	232	2	35	475	0	60.40	62	14.67	CHANGED	DELLAVLGYKVRSSDMA.-VAQKLEQLEhVMuss.p-DG.lSpLuoD.TVHYNPSD..LSsWlpSMLoELN.P.ssssstss	......................s-hh.-VAQKlEpLE.sh.s....................t-DG...lS.......pLASD....TVHYNPSD..LSoWLESMLSElN.s.ssp....s.s.......	0	7	24	29
+11875	PF12042	RP1-2		Tubuliform egg casing silk strands structural domain	Mistry J, Gavin OL	anon	pdb_2k3n	Domain	Spiders use fibroins to make silk strands. This family includes tubuliform silk fibroins which are used to protect egg cases. This domain is a structural domain which is found in repeats of up to 20 in many individuals (although this is not necessarily the case). RP1 makes up structural domains in the N terminal while RP2 makes up structural domains in the C terminal. [1]	21.10	21.10	24.00	21.30	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.27	0.71	-4.60	17	225	2009-07-09 10:00:34	2009-07-09 11:00:34	3	18	29	3	0	228	0	156.70	38	69.36	CHANGED	susupuuSuuuuuus.......uSAFAQu.hSuuLusSSsFusAFuSsoSsSuuuslAhpluhssApoLGl..ususALAuAlupAVuuVGs.GASusuYAsAlusAluphLuspGlLs..uuNAu.ulASShAsAlououuosu................utuputuuuSuhtpuuopouupoAus	.....................................sutuuutuuu.tuu.......uSuFupu..uuuLusSosFs...osFuSu....sS.tSssusluhphuhssAsoLGl..ssusulAsAluQA.VuuVGs.GASutuYAsAlusAhuphLuspGlLs..suNAu....oLASShASAlouSAuSsuush............ssu..tusupu....tuuuu.uhtpsuopSuutut..t...............................	0	0	0	0
+11876	PF12043	DUF3527		Domain of unknown function (DUF3527)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3945 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain has a conserved CDCGGWD sequence motif.	25.90	25.90	60.30	44.70	25.40	25.20	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.49	0.70	-4.91	12	128	2009-07-09 12:13:05	2009-07-09 13:13:05	3	4	19	0	91	118	0	219.60	24	44.32	CHANGED	SsophpuhLphshK.NGhPhF.Fslcs.c....-lhsAshh+ss.......sshshhYTFaohtt..++psuuhhsttp...p......lVGQMpVSs.hs.p.ttpt......hhpEFVLas...t.upp................p..ps.h.pt.t............p.....t...p.hptp..........sh.ps-LpssLElAAlVl.p.s..hpppps...................................h.tpSstsspV..llPuGhHGhPpst..uPSsLIpRW+SGGuCDCGGWDhuCsLtVLssttpps..pp.h.......tppsh-LFhpGspcps...PuLshsslc-GhYtVcFcupLSsLQAFSIClAhlHspc	....................................s..tuhlph..c.ps..hF.h.htt.p.....t.hsAp..p.s........tt.p..Yhha......p+tpt...t.............hluphpsSs....p.t...ttt.......h.pEaVLhs.......t....................................................................................................................................p.Eh.Ahl.t............................................................s..phpl..lhPsG.Huhsppt....tPssLlpRW+pGGt.CDCGGWDhuC.lhlLts...tt......t...................p.hcLhh............puttpt....shhphh.htpG.a.lpFpup.lo.LQuFuhslshlpsp.........................	0	12	57	73
+11877	PF12044	Metallopep		Putative peptidase family	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3942 (release 23.0)	Family	This family of proteins is functionally uncharacterised. However, it does contain an HEXXH motif characteristic of metallopeptidases. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 625 to 773 amino acids in length.	25.00	25.00	25.90	25.50	24.90	22.80	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.25	0.70	-6.02	28	198	2009-07-09 12:24:12	2009-07-09 13:24:12	3	6	159	0	150	210	5	375.90	31	58.75	CHANGED	shclhNlp-sph.VppsslllcGpssstp.....tssslpVppssp...t.aPshs..a.....................sVssup.........FKAllhLs..PGt.Nplphp.........h..........sssspsphlslpYpPhhps.Pl+Lslllu+DSstpaDusstphp..pptsssL-tAI+KlRhuuhLhQAFTsEpMhcsGaGpRoFpFpEEhphssh..........ps.h.+sph....KlHllRSc+TltElRc.slAQQNspupcsstLFshsh-slcphst......psspthpsushhLDo+aDs...ptp.............hIpGHAALGGGssp.lpLAIFGSHuLaSWPsshEpl.sssFpDsTpsssscVANDsNcsGThWEshslslGAahHElGHhhGsPHQps..GlMLRsYsp.h...NRoFhs+EshuhRocopG.....s.hhPpscC.....pWpRLDhLRFhhHPsFpLPtD...................sh.s.ssssha......shssst..shlsussGIh	....................................................t..pl.shppsph.l.p........hlllpGphsp.p................hsthlplpp.ps..........t.hPshs...a.......................Plp..s..up.........FKAllhLs..PG...Nplphp............h..................ss.psphlslpa.h.Phhps.....PlpLslllu+DSstp..aDss.tp.t..pp.sssL-sAl+KhRhuAhL.hQAaTuEpMhcss...............hGpRsFphpEEhphssh...............ps.h.+pph.....+lHllRop+TlsE.lRs.p....hsQQt...p.....upsps.tLaphshcslcphht......tstpp.hsushhLDo+aDsptp.............hlpuHAALGuussp.lpLAl.FGSasLaSaPssh-cl.sssFhDsT.pssss...VuNDsscsGo.WEshslslGAahHElGHhFGsPHpps...GlMhRsYsh.h...NRoFhs+EshshRspppG.......................t.hh..tpps............tWpRLDhlRFh.hHPsFplPtD....................h.sstt.pha......shtsst..hhhhs.sGl......................................................................................	0	38	74	127
+11878	PF12045	DUF3528		Protein of unknown function (DUF3528)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3981 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with Pfam:PF00046.	29.50	29.50	37.60	37.00	27.60	26.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.12	0.71	-4.06	29	255	2009-07-09 12:25:28	2009-07-09 13:25:28	3	3	89	0	82	221	0	140.80	51	50.90	CHANGED	sDFSSlPSFLs..psSSpPhTYsYS.SNL.PQVQPVREVsFRDY.GlDsSsKW.HaR......................GshupCY...........uuE-.lhHRDsLsssssh...uEhlhKN...su..ssh......Hsuos....uo.osFYusVGRNGVLPQuFDQFF-TAYGsu-s.sss-.hsssKsss+h...sssss	...............sDFS.olsSFLP..psoSp.hTYsYS.SNL.sQVQPVREV..o.FR-Y........ul-s.usKW.HaR.........................G.NhupCY...........S.uE-.lhH.RDCLsss.os................u-hLhKN.su..shh............H.uust.......so.osF...YosVGRNG...VLPQuFDQFF-oAYussps....sss-...stpKsttph.....sst......................................	0	3	11	38
+11879	PF12046	DUF3529		Protein of unknown function (DUF3529)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3346 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 176 to 190 amino acids in length.	25.00	25.00	27.80	27.30	22.60	21.60	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.88	0.71	-5.24	26	113	2009-07-09 12:27:30	2009-07-09 13:27:30	3	2	104	0	56	112	148	165.90	36	87.39	CHANGED	.ssshhSTLlLTlLLuIGLhFFlRAusKDRTshhclh....Ssps.......shplhstlppahcpRuaphsssDscppllpFcGtVtsShhLAlhLohLuulGhsCLGLVlp.LhPphuhW.lh.LslLu.PLAGhaYhp+ApR.Eplcl+Lhsss.pss.............sSplplcAHRDELh....pLtcsLpLpucG	..........ssh.oTLhLslL.slGLaFFl+uSsK-Rhpphphh....ssts..........tplhsplpsaFppRuaplss.p.ppphlsFEGhVtsShhlAlaLohLsslGhssluLVLshhhPs.....hu.......hhhh.LshLu.PLAGlaYWp+AuRhEp..lpl+lhsss...sts.............tStlplpuHRDElh....pLpcpLpLppp...........	0	15	40	52
+11880	PF12047	DNMT1-RFD		Cytosine specific DNA methyltransferase replication foci domain	Mistry J, Gavin OL	anon	pdb_3epz	Domain	This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties. [1]	20.70	20.70	21.20	20.70	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.64	0.71	-4.50	38	305	2009-07-09 13:01:57	2009-07-09 14:01:57	3	35	122	5	168	317	0	136.40	27	11.89	CHANGED	tcshPp+pLssasla-.scuchpsl-hh.hc.sh-l....ahoGhh.tsht......-sp..............sp.pt.............tuhpspu....lup......IcpWtIshh-..sut.shlhlsTshApYcLhKPuppYt.ha-hhhc.+splshtlhchLpcss....choh--llstltpt	.....................................................pthPp+plssaslas..pc.............u.chhsh-hh.hc..sh-l.....ahSGhh.pslh..........cpp..............sp.pt.................Ghps.cs......hus................IppWh.I..shhc........sut.sllsloTs.....hA.t.YhLh........cPoppYtsha..shh.c.+hhluhhllchLpcss.....choac-lls+ltp.s.............................	0	57	94	132
+11881	PF12048	DUF3530		Protein of unknown function (DUF3530)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2450 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 272 to 336 amino acids in length. These proteins are distantly related to alpa/beta hydrolases so they may act as enzymes.	29.80	29.80	31.40	30.30	29.30	29.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.88	0.70	-5.44	36	175	2012-10-03 11:45:05	2009-07-09 14:03:12	3	2	157	0	59	189	50	266.50	22	94.97	CHANGED	hhhthhLhhhhhhshh.......tt.........stptss.tss........................tt...............hpchLPs...................sEhptLps...sscphLsLhcstpsup.pGsllllsstspsADhsshlu.LRcpLsctGWsolSlo.Ps..........t...shh...ttsttsssssstp.ss.spp...........s..t.t..........................................phhptpp.......pplhsplsshhs..hspptsup.llllupGpuAshshchLupppssp........ss...................sLlhlssh.......hPsptt......tsLsphlup.lplPlLDlatss.pshshpsAt.....pRcptup+tpp.sYcQhtLht.....ss.ssppp...lhpplcGaLpphs	.................................................hs...................................................................................hpc.lPt............................................pp.p.lps.....ssppalsLapstpssp..GslIllsstspssDhsthlu.LRcpl.sshGWsoLolshPs.................t....h..........tsttsssssttt.ts.ttt..............................t...............................................................................................p..pspt.......ptlhsplpushs..hut.ppt.sc.llLlupGsuAhhshchluppp.st....p...................sLlhlss.........stptt.........sL..ph.lsp.lplshhDlh...hts.tsh.....stpsAt.....tRhphup+tptssYpQhsl.sh........s..s..psppp...lhpplcGWlpt....................	0	14	27	45
+11882	PF12049	DUF3531		Protein of unknown function (DUF3531)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2583 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 149 to 199 amino acids in length.	25.00	25.00	34.50	32.00	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.73	0.71	-4.53	21	130	2009-07-09 13:05:26	2009-07-09 14:05:26	3	3	98	0	64	130	123	144.70	44	69.87	CHANGED	McVpFREhsPFssWIWLcFussPopsE+pYl-plFcSWalLG+LGGFNAENLQlpEsGsDlSaMsYDs-ps....sushsALMHNMG-hEYpspWARCWhDLGTSDulALDVLINALpQlsp-hVpIccllIGG.N.EDWPlp..-pt-sh......Fsp	............McVpFR-FsPhs.sWIWlEFts.sPoptEhphlcplhpSWallG+LGGFNupNLQlp.p.suhD..h..uahsYDs-pu.....ssshsuhhHNhG-lEaQssWuRsWlDLGTSDhluLDVLINuLpQlSs-aVsIcplllGGpN..pDWshp.spp-....s..............	0	13	42	57
+11884	PF12051	DUF3533		Protein of unknown function (DUF3533)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2348 (release 23.0)	Family	This family of transmembrane proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.16	0.70	-5.71	39	601	2012-10-03 10:13:34	2009-07-09 14:10:01	3	6	468	0	205	969	15	280.00	21	43.58	CHANGED	shllLslhhlulhu.lYWGuhYppss+h+slphllV.tDs....s........tt..shlGssltshhsph.s............thss..aplhs.scat...........hspclhchlacp+YWuAlhlpsNATpsLhsul..ssusssasso..shhphlapouRc.oshsohlhs.lptlpphhht..hssphl..plhpshsshspsshht......hlssshsashhDh+PhsssshhussplGlIYhlIloFFp.........hshhssl+tph.....tphl....+htph......llaRhlsShlshFhlSLhashlo.huFplsF...................shsa...G+.uGFlVaWMhsaLsMtAlGhssEshshll....sP.aluhaLlhWlIlNlus..shhPhsLs....PsFYRaGYAh.PlHsshclh+sI...aasspp.splGhshGlLhAWlslshh	.........................................................................................................hh.................h.s...........h...s.....u....h.....a.....c....s...h.....s...phpp...l.lAVVNpDpG.............tt....s...s...lG..s..sh..s.shl.pp.ps..............hcaphh.......................................spccs.pctlp.pucYauulh..IPs.s.........hopplts............sl.......pst...p....s..s....hphp..................sssph.l...h..s.sup........t...s.s...h.......p.....p.........h.h.t.....p.h.h....p....slppshhp.....phsp..th..h.........s....l.psh..ss..................................................................................................................................................................................................................................................................................................................................................................................................................h....................................................................................	0	50	115	181
+11885	PF12052	VGCC_beta4Aa_N		Voltage gated calcium channel subunit beta domain 4Aa N terminal	Mistry J	anon	pdb_2d46	Domain	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins. [1]	25.10	25.10	32.50	35.50	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-8.10	0.72	-4.09	8	450	2009-07-09 15:44:57	2009-07-09 16:44:57	3	7	87	11	136	407	0	42.20	78	8.59	CHANGED	GSADShsS+PS-SDlSL-E-REu.................LR+EsERQAtsQLE+AKsK	......GSADSYTSRP.S.DSDVS.LE..E.DREA.................lR+EsE+QAtsQLE+AKoK..	0	16	28	69
+11886	PF12053	DUF3534		Domain of unknown function (DUF3534)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2753 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 150 amino acids in length. This domain is found associated with Pfam:PF00595. This domain has a conserved GILD sequence motif.	25.00	25.00	25.20	25.00	24.50	23.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-4.32	7	242	2009-07-09 17:29:17	2009-07-09 18:29:17	3	9	78	1	93	240	0	108.90	49	11.13	CHANGED	MKV.TVsFG+TtlVVPht-up.pVppL.........lppAs.RYt+spsptst.WlpVa+LE.asDGGILD.DDlltDVs-.D+DpllAlaDE...Q-s..tpGG-usSusSs......sppSP-.apsEhusp..huAFpPh..tuEI-VTsos.L+h...uhPLhVR..RSSDP	.....................................................................................st......hlpl.p+Lp.....spG.G.ILD.DDhltDVs-.D+-.......p.L.lAVF-E.....Q-P........ppuGDu.sS..uSSo.......GTQSP-h..FtsElusp..........huA.FpPh.......suEIEVTsSs..L+h...shP..LhVR..RSSDP.............................................	0	25	34	62
+11887	PF12054	DUF3535		Domain of unknown function (DUF3535)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2858 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with Pfam:PF00271, Pfam:PF02985, Pfam:PF00176. This domain has two completely conserved residues (P and K) that may be functionally important.	26.20	26.20	26.30	27.90	25.70	26.10	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.27	0.70	-5.86	32	289	2009-07-09 17:31:25	2009-07-09 18:31:25	3	20	241	0	212	284	4	412.50	26	24.30	CHANGED	VWpsLlpph.....s.pslssthssalpshlpLhhsPhGh.h.shsh-sslll+PSut...................thpstcpcptpptptt.....s.ts...ph.DsthhtG-lpllGhD......sllRsRltAA+AlGhhhuhh...spssltshhps...........hLhstLsSstusp+hluulllscaspstt.ppsts.................phhsttLhphLp.....t....p.shYcElsshl.ptlRspCpsLlsohtssuh.h....pls.lshhspupspssspuFol-sAcclssph....apchtpthsssp+l........uhpsLE-sRpplhsulpps+p..scpphcsplhuuhAuAllshpsLPcKLNPlI+sLM-SlKcEEsthLQp+SApulupLlp.hst...st+ssPssKll+NLCsalCsDooETPchs........................ssphppsILoLt......+cpspts..........................hssssphpcpscpApIpR+GuphulpplsppFGsplhsplPpLtshh	.........................................................................lW.tLlpph.....s.thl.....t..th.tsa.htshlpLhhpP.tl.....shchs.hhhcssutsh........................................t.tstphp.t.pttttt................t.....stp......h.h.ush......p.hl..s.-...........slh+uRlhAAcALGhlhshh.......spsshtshhp...........................................hLl.tL........sS.uuhp+lssuhlls-aAp.tttppshs............................................................................hlpttLhp.hLp.....................................c..hYcElss.h.pthpspCppLlsshtstsh.........................psp...sps......sss...sholc..pAp.clssp.........apchppshs..s..+h................................hp.LpspRpp...l.hslppspp...ppthphplpushAuAlls..........h..p..........tl..P.cK...LsPlI+slM-olKcEEs.t..LQphuAp.slApLlp.hs.........spp.sPssKllpNLsshhCsDsspTPphs................................................hpsthppsILoLh..............+cppttt......................................................................ts..sp.h..pctt.ct..ut.lpRRGAp.ALpplsppFGsplhpclPpLhphh..........................................................	0	67	112	174
+11888	PF12055	DUF3536		Domain of unknown function (DUF3536)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3129 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 274 to 285 amino acids in length. This domain is found associated with Pfam:PF03065.	25.00	25.00	39.30	39.10	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.78	0.70	-5.24	23	127	2009-09-11 10:41:18	2009-07-09 18:40:01	3	5	114	0	74	140	17	241.30	31	32.54	CHANGED	WsQp........WRsPLRcALDWLR-pLAthaEppusthhpDPWtARccYIcVlLcR.s.-shpsFltc+stc.lstc-plpsL+LLEhQRpuhLMaTSCGWFFDElSGIEoVQllcYAuRAlpLAc-lss.sh.EscFlp+LppAhSNlsphusGsclYcthV+PuhlsLhc.VuAHaAlsSLapshscps.hasYplt.cphchhtuGpsplAl...G+htlpSphThEptphhasll+hGsashpsGVp.apsppsatphhpplhttappushstll+hlsccFutpsYoLccLFp	.........WpQp........WRtPLRpAL-hLR-plstha-ptutth..h.p...D.PWtARc...cYlpVl........hsc......s........p......shppFltc.attp.Lstpcph..psL+LLEhQRtuhhMaTSCGWFF--lStlEslQhlpYAtRAlp.Lupch.......ss...........p...l....-tpFlptLtpA.SNh.p.htsGtplapphVhsshhsh.p.luuphA.lsslhpt...h................p..................t..thhs...apht..thp.....st..thhh..Gph.h.s.hT..pt..h.hssh.hGt.p..s.h................h.....t.................................................................................................................	0	33	59	68
+11889	PF12056	DUF3537		Protein of unknown function (DUF3537)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3199 (release 23.0)	Family	This family of transmembrane proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 427 to 453 amino acids in length.	25.00	25.00	32.10	26.00	21.30	24.60	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.39	0.70	-5.76	9	121	2009-07-09 17:42:07	2009-07-09 18:42:07	3	3	18	0	83	119	2	332.00	35	86.54	CHANGED	psscELt....pFcshLpWhshDpSs.hssslSW.lFhlLullVPhlu+hLLsCt....sC-.hppRsa-shVQlSLShhAuluFlsLSchhR+aGlR+FLFlD+LhscSp+VRhsYssclppSh+lLuhalLPCFsscusY+.IaWYhou.sphPalhpshhupslAChlph.sSWhYRTolFllsClLF+LlCaLQlLRh--FA+hF.....ptps-ltslLtEHl+IR+pL+hISHRFRtFILhsLllVTASQFsuLLhTT+sputlslhpuGELALCSlsLVoGLhICL+SAsKITH+AQulTulAo+WHsssTlsSh-ph........poPsus........hss..shp.ssstsssssEpsst....-DshcsTcI..hP.asp.shSaQKRQALVoYLENNpAGITVaGFhlDRoaL+TIFhl	..........................cpLp....pFcthLpWhsh-p..Ss....hshhhSahhFhhlulslPhhs.t.hhl.s.............s...p.csaph.Vphs.ohhAsluahsLophh++...........h.GLR+h..LalD.p.ltsc.otpV+tsYttp......l....ptuh+lLuhhllPshhscssa+.laaa...........t..h.P.........a....h.p....s.......h...pslAhhhth.sSWhYRTslahhsClLF+LlCpLQlLRhcsau+hh.....ptp.u-ltsllpEHhRIRcpLphISHRaRhFllhsLlhlTuSQhsuL......lhsst.........ps.hshhpuG-LAlsShs.lsGlhlsLpuAsKITH+AQulsulAu+WHshsThss.st.........tsPpss............t.......t.......s..pp..ps.-..t......ts.hs.ssph..hs.h...h.SapKRQAL...........VsYLppN.uGITlaGahlDRshLpslFhh...................	0	18	54	70
+11890	PF12057	DUF3538		Domain of unknown function (DUF3538)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3373 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain is found associated with Pfam:PF00240. This domain has a conserved SDL sequence motif.	25.00	25.00	34.40	32.80	22.60	19.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.57	0.71	-4.49	9	155	2009-07-09 17:48:44	2009-07-09 18:48:44	3	2	64	0	55	144	0	110.50	61	11.73	CHANGED	LsEVlQchRpVppRLpPFlpRYa-ILpsssTh-.pssTptREpsQRlhshVuEuLHhLupA.hAlSDLhhsLpsssPRHL.ssRPh.........S.ahssPshhssuhh.lPh.hslus......sVs...housGs	....hsEVLQELpRlEsRLpPFLQRYaElLssAsTs-Y.sNN.p.-GREEcQRllNLVGEuLRLLGNshVALSDLRCNLussPPRHLHVVRPM.........S.H.YTTPMVLQQAA.....IPIQINVGT.......TVTMTGNGp.....................................	1	11	16	35
+11891	PF12058	DUF3539		Protein of unknown function (DUF3539)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3564 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved NHP sequence motif.	25.00	25.00	45.40	45.40	18.90	17.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.07	0.72	-4.16	17	75	2009-07-09 17:50:22	2009-07-09 18:50:22	3	1	72	6	29	75	90	86.10	51	97.33	CHANGED	ssEpYLNHPTFGhLYtVsPss.....-u+-laATLYAQRhFFLVshpspG.........hpFEsIshtDARhhsEhpLpphRRss.opEhpphppl..FcQTFl	.s.sEpYLNHPTFGhLYpVs.ss.....-sp-lasTLYAQRlFFLVshpscu..........spFEsIshsDARhhsE.+LpphRRsG.sp-apphppl..apQTF.....	0	4	19	27
+11892	PF12059	DUF3540		Protein of unknown function (DUF3540)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2948 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 212 to 238 amino acids in length. This protein has a conserved SCL sequence motif.	27.10	27.10	27.10	28.30	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.19	0.71	-4.68	14	188	2009-07-09 18:02:22	2009-07-09 19:02:22	3	2	93	0	49	145	5	162.70	28	85.87	CHANGED	phs.upVtt...tts-shhlhpssGh.hps++AsSCLltPpsGDhV.Ll...........ssss-spphYllAlLpRssssss.tLphsG.clsLcs.tttlpl.usstlcLputp.plshpspchphpupphththpchph.upthpsphtpsphlucphcshhpRlhQpscpuhRpVcpl-pscAtplshpscpshph+u+psslTAcsllKlDupQIHhG	........................h..hupVht...hhss.hhhhht.ts...hpsc+AsSCLltPphGDhV..l............ss..ctpphallAlLtRssssts.tlth.sG..tlsLch........tsttlpltutcplslcst..phshpupp..........................hphlucphpshhpplhptstps.RpVpss-pl+Auphphtscpphth+u+pshlsAptllKIDutQIHhG...........	0	18	30	39
+11893	PF12060	DUF3541		Domain of unknown function (DUF3541)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2172 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 230 amino acids in length.	28.20	28.20	32.50	31.90	19.80	17.50	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.47	0.70	-5.06	17	126	2009-07-10 10:48:53	2009-07-10 11:48:53	3	1	122	0	23	93	2	222.40	66	59.53	CHANGED	sssp.oappsAphI+sshEspLYoLPshhpGHYGlRMYR.ThDsKYusAshsDhhpVssp.shaAsplcpPc.Itthuppclssht.....cs.RuptRhpAhcshPEaLahussLLt.huRhDEaGLpt.scs+LpplL++hDhcphhTD.tMIcAWAAQLAN.VYWh+QLG.tDhVpcahpAFpcsYPDspDpcLsppQatNKlYGMTHhIFAsSEYYQH.Vcpp-aQW	.......sss...hoaptoAsLI+pTYEoQLFTLPuFKEGHYuLRMYRQTLD-KYAAAIhSDLuRVAStLNaFAAEVsTPEQIppYupKRLppYp...cs-DERoQRRasATpsMPEYLYLGlDLLGsMARANEYGL..pH..Kp....DsKLRpVLRRYDFo.YATDcsMIEAWAAQLANQVYWLRQLGEQDVV-sFIpAFRcTYPDp+DscLscQQYGNKLYGMTHIIFADSEYYQHsVSpppHQW.	0	1	6	18
+11894	PF12061	DUF3542		Protein of unknown function (DUF3542)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2032 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes and viruses. Proteins in this family are typically between 516 to 1283 amino acids in length. This protein is found associated with Pfam:PF00931.	27.20	27.20	55.50	30.90	26.60	25.80	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.61	0.70	-5.50	6	85	2009-07-10 10:50:28	2009-07-10 11:50:28	3	7	5	0	0	85	0	331.00	57	41.90	CHANGED	hcEhIppTK.EhRApYS.FPpssLsuNcV........shcSPcFVMEhIDsVVtNLssLVKIsDssSh.FV.t..KcpIppVhKELKLLR.FVCFVSN+s.IEPQ.p+pTFas+sLhtAS+hAMVsWLY..hP....uNss.DLsPuEsspLLSDahcMKIKsIpPsIp+..IYIDVLQALKSTh.PpsQpcH......As..uGhVET.pHsL...........hVuLoDQMAshpEMLsLLRDNLIHLPILDLEFHLQDhDoVIlDuGLLlYSLYDhctp.EDsoLE-lNptLthDLP+sIE.IKhhlYLVhQKAFQsNLPRIHGLGYVDFLL+NLK-FQDRYSDS.LAFlKsQLQVIQpEhESLQPFLKsVsEEsHNKa-+..EcCss.lItKAYEVEYlVDAC...IsKcVPcWCLcRWLlDIIcEIssI.KtKlpE	............................................................................................................................................WKclIWKTKQEFRApYS.FPKosLAsNKV........s.tsPcFVMEhIDshVtNlNVLVKINDPsShhFVPG..KEQIEQVLKELKLLRFFVCFVSNKC.IpPQYppoTFYoHALIEASHIAMVVWLa..LPl.YGNtNQDLsssE..VSpLLS....DFhEMKIKsIpPslsp..IYIDVLpALKSTI.PpAQpKH.....sh...uuhVEhPsHsL...........hVGLSDQMAsLQEMLCLLRDNLIHLPI...LD.LE....FH.LQDMDSVIlDAGLLIYSLYDhcGphEDTsL--hNptLGFDLPRNIE.sIKsMVYLVMQKAFp...sNLPRlHGLGYVDFLLKNLcDFQsRYSDS.LuFLKNQLQVIQpEFESLQPFLKsVsEEPHNKhKpLNEDCAsQIIRKAYE..VEYVVDAC...INKphPpWClERWL.DIIEEITCIKAcIQE...........................	0	0	0	0
+11895	PF12062	HSNSD		heparan sulfate-N-deacetylase	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2134 (release 23.0)	Family	This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes.  This proteinenzyme is often found associated with Pfam:PF00685.	25.00	25.00	31.30	26.80	18.20	23.00	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.48	0.70	-6.10	7	310	2009-07-10 10:56:38	2009-07-10 11:56:38	3	9	87	0	174	264	0	383.60	61	55.88	CHANGED	hshsllSlhh.saaLaos..s+t.tpstcsst...phsC..s..hh......P.p.h.s+shc.....sss+TDPpVLVFVEShYSpLGp-IltILpSpRFpY+sElAsG+.slPsLTsps+G+YsLIIaENlhKYlNMDpWNRpLLDKYChEYuVuIlGFhpu.sEcsLhshQlKGFPLalasNltl+DhslNP.SPlL+lT+suchcpGsLPG.sDWslFQhNHSTYEPVLhuph+oscp..s..s.......h.hATVlpDLGLcDGIQRVLFGpNLsFWLHKLlFlDAluaLoGccLoLsLDRaILVDIDDIFVGccGTRhpscDV+ALlsTQNplRshlsNFTFNLGFSGKaaHsGT-tEDtGDDhLLpsscEFhWFPHMWpH.QPHLaHN.ohLhppMhLNKtFAl-HsIPsDhGYAlAPHHSGVYPVH.QLYcAWKKVWslpVTSTEEYPHLKPARhR+GFIHsuIMVLPRQTCGLFTHThFacEYPGG.pcLDKSIpGGELF	......................................................................................................................................................................................................h..hshh.hhh.saal..s......p........................ps....t...........................................s.p.......t..+o-..PhVLlFV.ES.YSpLGp-IltlLEusRFp..YphplAst+sshPsLT.-.....ps....+G..+asLlIaENlhKYlshDuWNRpLLD+YCh-.Y.uVGlI...G.Fh.+s.sE....poL.u..h...Q....LKG.FP...L.lasNl.tL.+DhplNPpSPLLhlT+sschc.GsL...PG..pDWTlF...Q.NHSoYpPVlh.Aph.......pstc.....s...h..s..t...........shhsTV.lpDhGLaDGIQRVLFG.ssLsFWLHK...LlFlDAlu.aLosc+LsLsL..-RYILVDIDDIFVGKcG..TRMpspDVcA...LlpTQp.LR..s...lssFTFN.LGFSGKFaHs.GT-t.EDtGDDhLLp.hcEFWW..FP.HMWSHMQPHLFHNt...S.....sLs-QMhLNKpFAlEHGIPsshGYAVAPHH.SGVYPVH.QLY-AWKpV.WsIpVTSTEEY.PHL+PARaRRGFIHpsIM........VLPRQTCGLFTHTIFYpEYPGGspELD+SIpGGELF..............................	0	34	48	107
+11896	PF12063	DUF3543		Domain of unknown function (DUF3543)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2213 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 217 to 291 amino acids in length. This domain is found associated with Pfam:PF00069. This domain has a single completely conserved residue A that may be functionally important.	26.30	26.30	27.90	27.00	25.50	25.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.41	0.70	-5.15	32	333	2009-07-10 11:05:01	2009-07-10 12:05:01	3	7	232	0	217	306	0	231.20	29	26.39	CHANGED	pss..cE-pc..slpplEphAo+u..cslhtFA-VKapQLhPhsP...............ts.s.spssh............psssLsscshhol........ScEuLVLYVKuLuLLuKuMclAusWWppppp......................sshts..Ss+lNplVQWlRsRFNEsLEKAEhl+L+L..pspphLspccsspsp........................sssloAEKLhYDRALEMSRsAAlsELsscDLtG.......CEluYsTAlhMLEAlL-s-..........................stlss-D+phlp+h......lsuIppRLssL+pKht	.................................................................................pEcschlptLp.hhths..cslhthAth+hsth..shss...................................................thttt.s......................................ss.hsphshph...............psEtLVLYlKuhpLLupuh.p.lAtt.hpp.................................................sphss.....Ssplpp.V.Vphlpp+appslppschlph+L....pphh.ccp..hsp.............................................psloAEKLlYs+Al-MspsAAl-Ehhp...p..h..ps........C.hpYppAlhhLEuLhcph......................................................................hctpDpp.lpKh.........................hpsIcpRLssLpp...t..............................	0	55	95	166
+11897	PF12064	DUF3544		Domain of unknown function (DUF3544)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3553 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 198 to 216 amino acids in length. This domain is found associated with Pfam:PF00628, Pfam:PF01753, Pfam:PF00439, Pfam:PF00855.	27.00	27.00	91.00	58.30	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.52	0.70	-4.53	4	139	2009-07-10 11:09:03	2009-07-10 12:09:03	3	9	40	0	32	136	0	190.30	79	18.22	CHANGED	uKPVLuGus....GRRISLTDMPRSPMSTNSSVHTGSDlEQ-sccK......soSSHaSAuEESMD....STASPASsKsG.uGshusSPKPFpspsus...oKQE+ousTGSILNLNLDRSKAEMDLKELSEoV......QpQussssLhSPKRQIRSRFQLNLDKTIESCKAQLGINEIS-DsYsuVEHSDSEDSEKoDSSDSE.hSD-EQKsKNpp-ssps+Eu	...........SKPlLSGGs......GRRISLSDMPRSPMSTNSSVH..TGSDVEQDsEKK......AsSSHFSASEESMDFLDKST......AS....P..ASTKsGQAGSLSGSPKPFS.PQhssP..lsoKt-KT..S..TTGSILNLNL.DRSKAEMDLKELSESV........QQQSs..PVPLISPKRQIRSRFQLNLDKTIESCKAQ.L.GINEISEDVYTAVEHSD....SEDSEKSD...SSDSEYlSD-EQKsKNEPEDsEDKE.G.......	0	1	5	13
+11898	PF12065	DUF3545		Protein of unknown function (DUF3545)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3270 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 60 to 77 amino acids in length. This protein has two completely conserved residues (R and L) that may be functionally important.	25.00	25.00	30.70	45.40	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.12	0.72	-4.22	22	162	2009-07-10 11:21:43	2009-07-10 12:21:43	3	1	162	0	38	93	1	59.60	52	94.82	CHANGED	MDphph....D-llth.-ps...ppo+u+.s.pKRKWREIEAlKD+pRLpKELp-hDhsh-.hsl--...lch	......MDpLca....DEllch.Ehsp.hcpSRoK.P.sKRhWREIEAI+DR+RLcKELh-hDsshD...hD-Ic..............	0	7	14	26
+11899	PF12066	DUF3546		Domain of unknown function (DUF3546)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3237 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 93 to 114 amino acids in length. This domain has two completely conserved Y residues that may be functionally important.	25.00	25.00	26.10	26.10	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.46	0.72	-4.05	19	273	2009-09-11 14:59:35	2009-07-10 12:24:31	3	13	212	1	194	287	0	104.60	30	13.50	CHANGED	oaKpFhts..-Dslscs-uhp+YscYKh-apppQhpcFF.tHK-E-WF+pKY..HPcphsphpccppphhpsphpsFhp.hcsGhhsplpl-ht.t....chhsssllch-sGspp-	................hKtFh.p..--shscs-s.p+YscYKt-apppphpsFFptHKcEE....................WF+pKY......cP-..p..hs....thppctpph...hpsthp.Fhp.lcsGhhDph.l-h..t.....p.hssshlchEtGpt...................................	0	67	109	159
+11900	PF12067	Sox_C_TAD	DUF3547;	Sox C-terminal transactivation domain	Assefa S, Coggill P, Bateman A, Eberhardt R	anon	PFAM-B_3310 (release 23.0)	Family	This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with Pfam:PF00505. It binds to the Armadillo repeats (Pfam:PF00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation [1]. It functions as a transactivating domain (TAD) [2].	25.00	25.00	25.30	27.10	22.80	24.20	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.68	0.71	-4.14	12	166	2009-07-10 11:26:27	2009-07-10 12:26:27	3	4	45	0	80	139	0	182.20	34	53.20	CHANGED	hsshua.aR-htshG..spa-s...YuLPT.PEhSPLDsh-...s-suFFss............ss.pE-sphh.......s.hsYpssas.........pp.pssshh+phshsps...ssst.............shhss.sssthY..uphhss.pst.has.......phG.QhSPPPEut...ph-sl-plpps.-Lhu-lDRsEFDQYLs....ts+s-ht....hsaps..............ss.ssspp...ssL.SlLSDAooAsYYsshss	........................................................................s...tpaR-h.shG......sph-s...YuLPT.P-hSPLDslE......s-.sFFss..........................sh..--pth.............................s..sa..p..s..t...hs......................p..tss....h.tt.hshs.s...ss..........................h.ts..s.ss..thY..sthht............s..............tst..hps..................thG..QLSPPPEs.........sh-uh-php.s..ELLu-hDRsEF-QYLs....tpp..s-hs..........Lshps..............tp............................ss.ssspp.....sul.SlLuDAouA.YYsshs.s................	0	5	10	32
+11901	PF12068	DUF3548		Domain of unknown function (DUF3548)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3247 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 184 to 216 amino acids in length. This domain is found associated with Pfam:PF00566. This domain is found at the N-terminus of GYP7 proteins.	27.00	27.00	27.00	27.40	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.31	0.70	-5.04	9	226	2009-07-10 11:34:16	2009-07-10 12:34:16	3	4	118	0	123	196	0	178.70	30	28.80	CHANGED	ssshKVlFEK-GValHosst+..p-pDshIsGhlRll.EKcu-lhl-WpPlE-.shssstlhhttcsupus............ctscassuYEs-WshloTVshcc+.ttpt....stssspu+W.uFohsLs-L+Sl+ps+.uh...GasYLlhss+cGssLPsLHFHpGGo+thL+sLp+alhLspSPpDu+lhLVhsps.pALSpSF-pL.....--sohsllp+ahpD	.....................................................s....pllapppsValHssstc.....cs.IsGhlpll.....p.....cc......s......p...sh.lcat.....Ph-.-.....s.s..ssthhhs.tps..sps.h.............................................p...sph.ssh-s-W...shlso.....sp.....p..pp.t...p....st.......s.....s.....s..t....s...s..t.u..pa.....uF.s.hsLs-L+Sl+ppc.uh...GW..sY..LVhsh+.sG.ssL.PALaFHpGso+.hlcsLppal.hLspSspDtphhLV.sps......puLspSFppL....pps..s.shh...............................	0	31	49	85
+11902	PF12069	DUF3549		Protein of unknown function (DUF3549)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2034 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 340 amino acids in length. This protein has a conserved LDE sequence motif.	57.80	57.80	86.90	86.80	27.30	20.30	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.11	0.70	-5.66	29	187	2009-07-10 11:52:14	2009-07-10 12:52:14	3	1	184	0	44	152	13	331.00	50	98.51	CHANGED	MspIsTLophLpsussQaplaDlGRRVpcIstppFtpIEptptPYPaPlQpHAphAIsF.W..sts..........pQsaIWFLKLPLDE+GLLp.AsRspFIchllEALGppLspsho--.QQ..ppLusNPYsFKPsp-KhAhFpAhl+tpLspssSpaYEhAtpYLSuph....s......h-sWQslGLQGIADlssRlpppsp.tshltcAlsp....hPtpVhhALstsLEHhs.lscpLu-tlhpphppt......cshhhshhlRALuu..usspshpsh.h.slLsptphhcs-..lLlsIAu...RsWpsL.p-spthphaL-pLAppp..Q....shFsQlFADLVtlPtLRstlLshLRpsspSstLupAIupLFp	....M-sIpTLopLL......psossQYQlFDLGRRVptlDsppFtplEtuQpsYPaPlQpHAphAIsa.W..spp..........+QPaIWFLKFsLDERGLLpQAshupFIphllEAhGscLsp........slo.EE...QQ.....pKLANNPYTFKPo--KlAhhHuplRtpLsLssSQYYEHAQp.YFSGsLG..........W-pWpoVGLQGIsDlCAR............Lpp-pN.ushLc....KALs+.............LPspPLaAlhusLEHls.Ls-cLAc+L.EhspsplttppsDlhLLuAllRALAu....ussshhpsh.hsulL.............sS...stls+sE...VLIulAG...RsWhsL.psssptppFLhRLApsts.Q.....sLFNQLFADlVhlPsLRsshLsLL.cussSspLApAltpL.p...................	0	8	18	32
+11903	PF12070	DUF3550		Protein of unknown function (DUF3550/UPF0682)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2472 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 249 to 606 amino acids in length.	25.00	25.00	27.50	26.70	17.50	20.60	hmmbuild  -o /dev/null HMM SEED	513	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.76	0.70	-5.76	6	181	2009-07-10 11:59:48	2009-07-10 12:59:48	3	4	103	0	130	194	0	376.60	40	82.71	CHANGED	CaLL-KS+pLFNuLRDLPQaG++QWQsYFG+TFDVYTKLWKFQQQHRphLs.chGL+RWQIGEIASKIGQLYYchY..LRTSETsaLsEAFsFY.pAIhsRuYaspss+E-..s-Lhs..K+LRaYARFllVCLLLs+h.chVt-Lspclcphl--hppsapscDptEWpLVlpElsuFlcADs.ltVLpsDphslhhsp.....c.sPhst.Pshtpsshpp..LSLp-uLlhusspsplKFoELTlDhFRMLQsLEtEPssuh.ph...............htpth...t.stpsu.....ltEsuccPshRsNPHKYLLYKPThSQLhsFLusuFKELPsNuVLLlYLSAsG...........................shsos+pst-uPY-hGGlhTusp.+shssGsslphRspu...tKEs.HCLYPGDLhPFTRKPLFlllDSssShAFKshs.shFGQPLlhLLSP..sohPsuhp-p..sp+GSLFThFLpuPLhAFsalsGlu..clctcLW-+sQchLc+hhs-huplLsc.SRs.........lD.salQFhGD-FLRhLlLRFVFCpush+l.H+sF+	.....................Ll-+ucphFstlRDLP.aG....ptp.....pta.Ft+sFcsYT+LWKaQQppR...thL...s.c..hGL+RWpIGEIAS+IuQLYYthY..hRTS-spaL.Eua.FY.tAIhtRtYapp.......s...t.....t...........................cLhl..KpLRahARFllVsLLLp+h.chVppLlpclpt..lp-hpp.pap...p..-.hEWphVlpElttFlcA-s.hh..hps.p....hhhsp....................................t..sh...s.htp...h.t...LpLt-hllhu.tp.pp......lKFoELTlDhFRMLQsLEhEP.t.h.p................................................t.t...........h.p..s...pp...sh..NP+KhlLY+PohophhshLus.hc.....E..Ls.suhlLlYlSAsG.....................................................................................s..pt.p..t..p....s.......p...s..t......t...p................t......tsp.t..........tt....p.laPtDLhPFTR+PhFlllDSpsShsap.................t..h.....t.hGpPhhhLhSP.............t.h..s..hts.........ttpGs.FThFLpsPh.Ahh.h.sls.......ph..thappspthl..tp..t-htt..hlhp.st............l..p.sahphhsD.FLRhLlhRalFCpsshth..............................................................	0	47	68	99
+11904	PF12071	DUF3551		Protein of unknown function (DUF3551)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3610 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 79 to 104 amino acids in length. This protein has a single completely conserved residue C that may be functionally important.	26.50	26.50	34.20	28.80	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.19	0.72	-4.43	37	127	2009-07-10 12:00:59	2009-07-10 13:00:59	3	2	24	0	54	129	3	83.00	30	89.04	CHANGED	MRphhhsshuh......................................shshhhsssssAp.A+D.YPaCLp...usthuas.GcCsasoapQCpsoASGpsApC.......shNPhhs..h..spsppttptp	...........................................hhhhsh.....................................hssshhhss.sssAp..A..t.-..a....saClp........utthuhs..ssCsasohtQCpAoASGp.sAtC.......shNPhas....h..st.tt.....t.................	0	4	14	28
+11905	PF12072	DUF3552		Domain of unknown function (DUF3552)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3508 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 200 amino acids in length. This domain is found associated with Pfam:PF00013, Pfam:PF01966. This domain has a single completely conserved residue A that may be functionally important.	29.00	29.00	29.00	29.00	28.70	28.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.39	0.71	-5.10	58	2218	2009-07-10 12:04:02	2009-07-10 13:04:02	3	6	2166	0	441	1381	168	199.80	32	38.76	CHANGED	hhllhs.llull.VGhslGahl.....RKpluEp+lssAcppAcpIl--A.....................c+-AEshKKEAlLEAK-Eh++hRsEhEcEl+-RRsElQ+.EcRLlQ+EEsLD+Ks-sL-c+EppLpcKEpplttppp.lcppcpcl-pllpcQppcLE+ISGLopEEAKphllcpsEpElp+EtAhhIKEhEpcAKEcADK+A+cIluhAIQRsAADa	.............................................................................................h..llhhllshl..lGh.s...lG....ahh..........................t+...ph....t....pp...p....htpAcppA.c.pI..lppA..............................c...+...EA-....sh....K...KEt..lLE.......AK...E.E....h...........p....chRp.......-.......hE...p.......E.......h....+.......p+...Rp......E....lp....c........E.p....R...Lh....p.......+.......E....c.s....L.-+....Kp-....p....Lcc+.......EppL.......-p+.......cpplt.......p.......c.......tpt.......l.......-p..+cpclc...........clhpppppE......LE+I.......uuLop-EA+phlLpplEc-lpc-hAhhl+-hEp-AK-.cu-KpA+cIlspAlQRhAu-h............	0	198	340	403
+11906	PF12073	DUF3553		Protein of unknown function (DUF3553)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3361 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 60 amino acids in length. This protein has two conserved sequence motifs: GQVQS and TVNF.	20.30	20.30	20.30	20.40	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.59	0.72	-4.65	22	88	2009-07-10 12:12:10	2009-07-10 13:12:10	3	2	88	0	32	90	325	50.90	50	47.26	CHANGED	LEPGhhVRHPspPDWGlGQVQSNIuuRlTVNFcctGKlVIDus+VsLhhVh-	.......LtPGhhV+HPspP-WGhGQV...QS.....slus+l.TVNFcctGKhVI-uspVtL.hV............	0	10	24	28
+11907	PF12074	DUF3554		Domain of unknown function (DUF3554)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2029 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 287 to 356 amino acids in length. This domain is found associated with Pfam:PF02985.	25.00	25.00	25.10	25.40	24.50	24.60	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.88	0.70	-5.01	30	248	2009-07-11 10:07:29	2009-07-11 11:07:29	3	46	204	0	185	264	0	312.50	20	13.21	CHANGED	s-p+slhsphLttl.s.tt.............lSpclspulhsllsKE....uNEsuLsphlsshspahhtl.......psclscclsstltK...Ghs-K+.s..lR+hWhhphsshhh............pstshshsspFhsthhphhccssssPhssspssslsuAalllu.........t..........t...h..hhhs.+sshLhss+haoK.ssps-lpahhcsLpslhsstp.p.ttpt....saupAhlaslsus..phssRcpAhphLpplhtppsth.......lucsllsulhshltshchh............stssshchlphlhpsls.s.sshst..........hcp.hhpLLllup.thls.t.....sWhuLs.+s...plDPupllpcpsc	....................................phl.tls..ts.............lutplsphhhshltcE....spEssLhttlpshshahshh.........pspls..cplhphhtK...GhspKpss..lR+salhphhthhh........................ss.shthhts.llshLhphhccshsp.sh..t.ss..t..ss..th...suAhllhs..............ths..htt.........t...h..pl.h.....h.s...K..ph.hhs..+hhpp.....ssp-shhhh......hchhp.tlhhph.tph.ttth.....pthtpAhlhhlhut..shp.lRcpA.hp...slpplh.tp.sth...........lups..ll.ptlhph.lpshchh..pt...............ttssptt..p.h.hh...s.pslp.s...s.hpt...........t......hcp.hhphLllu+p..l..sts........Whs.Lhh+h....tlDPtphlpc...t.......................................................................................	0	49	92	149
+11908	PF12075	KN_motif		KN motif	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3795 (release 23.0)	Motif	This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with Pfam:PF00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors [1].	19.50	19.50	20.50	19.80	17.80	17.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.95	0.72	-4.16	15	233	2009-07-11 10:36:48	2009-07-11 11:36:48	3	29	67	0	116	195	0	39.40	60	4.24	CHANGED	PYSVET....PYGYpLDLDFLKYV-DIE+GsTIKRl...slpRRs+	...........PYSVET....PYGacLDLDFLKYV-DIE+G....s....Tl+Rl.......slpRRs+.............	1	15	25	59
+11909	PF12076	Wax2_C		WAX2 C-terminal domain	Assefa S, Coggill P, Bateman A	anon	Pfam-B_3756  (release 23.0)	Domain	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 170 amino acids in length.  This domain is found associated with Pfam:PF04116. This domain has a conserved LEGW sequence motif. This region has similarity to short chain dehydrogenases [1].	27.00	27.00	36.20	36.00	26.70	26.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.95	0.71	-4.51	10	156	2009-07-11 10:43:14	2009-07-11 11:43:14	3	5	27	0	77	166	5	157.20	47	28.21	CHANGED	VlLpGssoKVARAIAhuLC++sl+VsMh..sKE-acpLppcl.sschpcNLVhSpo...aos....KlWLVGDGLoscEQh+ApcGTLFlPFSpFPPpchRKD.CsYpsTPAMtlPKohpNlcSCENWLsRRVMSAa.Rsu..GlVHALEGWscHECG.sph...ul-+l.....WEAAL+HGFpP	....................VhLpGsh..SKl..upAlAhhLCp+tlpVhhh..sp-cappl.ppch.ss-hpphLV.......s.op...aps.........KsWlVGchlsscEQthAPtGThFh.Fs....P.h....p.hR+D..CsYtphsAMtlP.cs.hpslcoCE.hhsRtVhpAh.+su..GllHsLEGWstHEsG.....sl...cl-hlWpAALpHGFpP........................	0	10	46	66
+11910	PF12077	DUF3556		Transmembrane protein of unknown function (DUF3556)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2567 (release 23.0)	Family	This family of transmembrane proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 576 to 592 amino acids in length.	25.00	25.00	238.70	31.50	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.75	0.70	-6.50	14	188	2009-09-11 14:10:01	2009-07-11 12:04:22	3	2	108	0	38	132	5	566.10	57	98.52	CHANGED	MGFlpPchPsVDhsEWpctsRu-Rl+sMAcHWAEhGFGTPhhlHlhYllK.IhlYlLGuWlls.htTsGlsGhscluuWWsEPIVaQKlVLaThLFEVlGLGCGaGPLssRFaPPhGuILYWLRPGTIRLPPWPc+VPhTpGspRTshDVsLYuulLssllsALhosGs.....GPlsth.....sstlGllssWplssllslLuVLGLRDKlIFLAARGEhYushhlsFhF......G...usDh......IlAsKllhlslWhGAATSKLN+HFPaVlusMhSNNPlh+s+...hlKRpha+caPDDLRPStLuchlAH.huTslEhLVPLlLhFupuGas.TslAAsl.MlsFHLsILSshPMGVPLEWNVFhlFullhLFlua...uslGls-lpsPh.lulLhAslssssllGNLaPc+lSFLPuMRYYAGNWsTolWCh+P.uA--Klcp.sllthuuhstsQLp+h.Yus.EsAplhhahuhAFRuMpoHGRALhoLhhRAl.ustDED-YslpEGEhlCusslGWNFGDGHLHNEQLIAAlQpRCsF-PGElRVllL-uQPIH+QpQpYRlVDAATG.hERGYVpVuDMlscQPWs-...........-...lPVcVt.s	..MGFLpPcLPD.V.DhspW.ptsRpp+lpshupHWAEhGFGTPhhlHLhYlsK.IhL.YlluGhhIl.hhTsGlsGh...oclusWWspPIVaQKVVlaThLFEVlGLGCGaGPLssRFaPPhGuhLYWLRPsTIRLPPWPD+VPaTpGspRTsVDVALYAllLhhllhALhos.Gs.....sPlsth........GstVGLlssh.lVshlllLuVLGLRDKsIFLAARGEhYhshhlsFhF.............s...hsDh......IlAhKllhLslWhGAATSKLN+HFPaVlusMhSNNPLlRsR...hIKRhha+caPsDLRPuhLu+lhAH.suTslEhlVPllLhhu..psGaP.ohlAssh.MVsFHLsILoslPMGVPLEWNVFhIFullhLFlua......uslulsDlcsPl.LAlllAVlAhlVIhGNLhPcKISFLPuMRYYAGNWsTolWCh+P.uAEsKlpp.ulVt.uuhsssQLt+h....Yss.-pApI.h.hs.hAFRAMpoHGRALhoLhhRAh...cDEscYsIp-GEhlCushVGWNFGDGHLHNEQLIAAlQcRCsFpPGElRVllL-uQPI..HpQpQpYRlVDAATG.FEcGYVpVuDMlsRQPWs-...-.lPVHVt..p..............	0	7	22	33
+11911	PF12078	DUF3557		Domain of unknown function (DUF3557)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2154 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 150 amino acids in length.	26.20	26.20	26.30	26.30	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.91	0.71	-4.50	33	542	2009-07-11 13:46:58	2009-07-11 14:46:58	3	7	5	0	539	545	1	145.30	20	38.35	CHANGED	Kl+-Ah+YLlp+Lh..uuRss.lplpp...Lplss....tslL.RlP...psl+l+lppLcl...sspsspllcsl..psllcsoohPLpolplsss........phscsllpouchLhltsthh.............ptLhplpsp+Vclt......hshpphhcL.lcpW.lcpu......+p.lGThaoFshpp	...........................................pshchlhphhh....ss.R...p.t...l.pVpp...lt..h.t.t..................tt.h..h..phP......sh..+h.c.l.p.pLph..............hp..........phhptl..........s.hl..c.s.ohPLcp..l.phtht..................tth.cp....sl.lp...s.AcpL.hlpt.h.................................phltpL.p.Npp..lhlp.......ththsh...p..s..h.htl....lcpW.hpst......+p.lGTpaph....t...............................................	0	42	43	539
+11912	PF12079	DUF3558		Protein of unknown function (DUF3558)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3489 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.49	0.71	-4.61	27	517	2009-07-11 13:51:31	2009-07-11 14:51:31	3	3	154	0	133	423	2	165.90	21	85.88	CHANGED	sssluGCu..s.sGsssstsssss....sss.....phss........hhtt..CssloDspl.schh......Gsssh.h....ssshsus......sCpWptss......h....shs.loh.aacsuslspERphtpththslp-h....sIsG+puh.hupssss.....sssCslsl.stusshls.....W.l.phps....tshs..Ds.C...shApcLspholsps.	.............................................h..hlsGCs....s.s..Gs..s.ss..ussss...................sps.ts.sptp.ss...............................hhc...C.ts.losptl.sc.hh.................Ghssh....h........psshsus...........tCpWpuss......h................ths..loh.....h.hp.....ts.s...l....s...p...p...c....p.....ssctht.hp...s.psh..........sIsGp.......su..h..hhtssps.......susC.tVsh.....tsu.s.....s...h..lp.....hsl....shps......sts....Ds..C...s.Atclhp.sltp..p...............................................................................................................	0	28	94	120
+11913	PF12080	GldM_C		GldM C-terminal domain	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3275 (release 23.0)	Domain	This domain is found in bacteria at the C-terminus of the GldM protein. This domain is typically between 169 to 182 amino acids in length. This domain has two completely conserved residues (Y and N) that may be functionally important. GldM, is named for the member from Cytophaga johnsonae (Flavobacterium johnsoniae), which is required for a type of rapid gliding motility found in certain members of the Bacteriodetes [1].	29.00	29.00	35.80	34.80	28.40	26.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.00	0.71	-4.33	26	164	2009-07-11 14:11:47	2009-07-11 15:11:47	3	3	148	0	57	170	155	176.40	31	35.45	CHANGED	sIuuDKMNVlYRGlsNPhoIulPGlssspVs...uous..G..Lp+tuss.tahhpPs..p.Gpc.lpIsVoup.ss.Gpsls.sppsFRlKslPsPh.........Gslpspt....ssphs+psLpsus.lsAsh.pDFsF-lshpVsuFplplssp.....ssltlsGschsups+shlp+sc+G-tl.ItcIcsphss	........sluADhMNVLYtGh..sNPloIShPGlssspVs...sohs.....GupLsppGsu...palsp....Ps....s.Gpc.lsIsVoup.....Gpshp...uphsFRV+plPcPs.........ushpthp.....ssthsKssLhsss.lsAsl.-Dh.hD.lsapVsuFch.hh..hcp.......sslsssGsphos..pt+stl+php+GcphhIsclpspss.s..................	0	28	51	57
+11914	PF12081	GldM_N		GldM N-terminal domain	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3275 (release 23.0)	Domain	This domain is found in bacteria at the N-terminus of the GldM protein. This domain is typically between 169 to 182 amino acids in length. This domain has two completely conserved residues (Y and N) that may be functionally important. GldM, is named for the member from Cytophaga johnsonae (Flavobacterium johnsoniae), which is required for a type of rapid gliding motility found in certain members of the Bacteriodetes [1].	25.00	25.00	29.70	25.60	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.17	0.71	-4.78	30	171	2009-09-11 04:40:41	2009-07-11 15:15:05	3	4	147	0	54	178	163	186.50	24	38.17	CHANGED	EVLsuFshhN..cpLcposssscppNcpshssL..ssKss-sstchtphhppAppl+ptoschhsalpslKpplhpsss..ctp....hpshc+sstl-..pthhhGst.hsscGp..clhpclspY+stlhthh..stphpp.hh.ttlptphssss......ppps.tppcahphpFps.hPllAulshLTphQs-l+psEu-llspLluut	.........................................................................................-VLsuFshlp..csLppostsssp...pNpthhpsl..ptp..hppsst..+htthhp.cAppl+pho.cslhsalppLKtplscp...u-st..csp...........htslc.pp-sl-.s.......sthhh.us....hsscGp..cLhpplssY+..pplhphl.............t..hpt..hh..phlp.sphsTpss....................ppps.ts+sW.phhFcs.hPssAulThLoplQuDl+tsEu-llpsLlss.h........	0	26	48	54
+11916	PF12083	DUF3560		Domain of unknown function (DUF3560)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2138 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain has a conserved GHHSE sequence motif.	27.20	27.20	27.40	27.40	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.68	0.71	-4.08	24	275	2009-09-10 16:38:42	2009-07-12 10:48:23	3	5	224	0	27	224	3	124.50	54	30.84	CHANGED	sshtpRtpsRspRapshAs+Asscucptaptucphs-slPh.GQPILVGHHSEpRcR+hh-RhcsshtKAlthp-KAc.......aapp+A.tusspsshspcsP-s.lc+l+thhAsh+pspcph+sts+hl+pt	.....os..LsERQEARAERFouYSuKRAuESsQAl-cV-RLAuhIP..GQPILVGHHSERRARRDAQRIENGMKRA.VMLaERAE.......YWEERAc..S.AL.hHAKYKERPDV..RaRRIKKIEADLRKAEKoIApSpKYLsha............	0	6	17	26
+11917	PF12084	DUF3561		Protein of unknown function (DUF3561)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2401 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.	25.00	25.00	27.40	27.20	22.90	21.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.51	0.72	-4.20	10	531	2009-07-12 09:49:57	2009-07-12 10:49:57	3	1	525	0	37	121	1	104.80	72	98.87	CHANGED	MRNopNl.hlopsDs.hppcDEsTaShsGAVVGFlSWLLALuIPFLlYGuNTLFFh.LYTWPFFLALMPVuVlVGIALasLLcG+LlYSlhuTlloVsslFuhLFhWLhG	......................MRNSHNI.TlT.s.NDu.hsEDEETTWS.LPGAVVGFlSWLh..ALAhPh.LlYGS.N.TLF.FF.lYTWPFFLALMPVAVVVGIALHSLhcGKLhYSIlFTLlTVGlMFGALFhWLLG......	0	1	8	21
+11918	PF12085	DUF3562		Protein of unknown function (DUF3562)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3549 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 62 to 84 amino acids in length. This protein has two completely conserved residues (A and Y) that may be functionally important.	26.30	26.30	32.40	32.20	25.00	23.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.04	0.72	-4.15	14	97	2009-07-12 09:51:43	2009-07-12 10:51:43	3	1	71	0	22	65	2	69.50	39	94.74	CHANGED	hs.ssh.............-tlcphApcpuhss-.Vcphhs-phcsLuu-ARVHDYlplFAhR+VRcphR....................spsstt+	................MhQssl.-.lpulApcpshss-tVpchh--plspLusGARV+DYLpVhshRRVREplR........sR.....st...................	0	2	4	13
+11919	PF12086	DUF3563		Protein of unknown function (DUF3563)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3639 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 50 amino acids in length. This protein has conserved AYL and DLE sequence motifs.	26.90	26.90	26.90	27.20	26.50	24.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.92	0.72	-4.22	5	136	2009-07-12 09:54:44	2009-07-12 10:54:44	3	1	79	0	42	82	23	51.90	45	93.77	CHANGED	MYL...lS+LFLFLTKshDpusKEcp...DAYLAEATDLYDLEFRMRKID.R-Ash+pPSshss+	.....................huhlh..hLop.hE..p..s.....t+ERp...-AYLAsuoDlhDLEhRhRpL-...pshu..........h................	0	1	10	22
+11920	PF12087	DUF3564		Protein of unknown function (DUF3564)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3736 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 118 to 142 amino acids in length. This protein has a conserved WSRE sequence motif.	25.00	25.00	44.20	99.20	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.71	0.71	-4.53	7	93	2009-07-12 09:56:13	2009-07-12 10:56:13	3	1	57	0	26	75	2	119.20	52	95.53	CHANGED	MRlTl+lsT.-sss.tuaAlLWLDpsp+tWSREuHtGl-LPpWGsltsspGsstl...suADsspslCpLpGLclsshpGshEu.EpGpAhWh..ut+sPhhGtW+lQsVDpssspPEat.Fsttp	MRLTI+ls.u.-uss...puaAVLWlDTDEphWSREuHpGIDLPsWGcV+sspGsstL...CuADsscuLCpLcGLshust..............pt...Es.EpGsAhh......us+sP..sGAWRLQsVDpssspsEHc.FTsht..	0	2	5	17
+11921	PF12088	DUF3565		Protein of unknown function (DUF3565)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3033 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 30 to 78 amino acids in length. This protein has two conserved sequence motifs: WVA and CGH.	25.00	25.00	29.40	29.30	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.18	0.72	-4.20	19	114	2009-07-12 09:58:00	2009-07-12 10:58:00	3	4	112	0	40	105	12	56.00	50	70.94	CHANGED	lGaHpD-EsHWVApLuCGHsQHVRHpPPWpsRsWVlT.pGRpshLGt.LsCtKC-puustD	..hsacpD-EsHWVA.LuCGHsQHlRHpPPWpsRsWVlottGRpphlGphlsCt+Csputs........	0	10	19	32
+11922	PF12089	DUF3566		Transmembrane domain of unknown function (DUF3566)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3331 (release 23.0)	Domain	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.	45.90	45.90	52.10	51.60	38.50	38.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.53	0.71	-4.09	24	434	2009-07-12 10:02:00	2009-07-12 11:02:00	3	1	432	0	113	310	175	118.90	40	54.26	CHANGED	ssRRscLplsRlDPWSshKloFllSlulhllhlVAsslLahlLsuhGVFsplsshlsslsssssu......sltshlohGpVhuhusllullsVVLhTALuTluAhlYNlsusLlGGlcVTLu-c	......psR+ApLplsRlDPWSshKlShlLSlAhhllhhlAsslLahlLsuhGVasplNpslsslhsssuu......phsp..hlohGpVluhssLlGslNsVLhTALuTluAFlYNlsusL..lG.GlEVTLu-c..	0	34	83	105
+11923	PF12090	Spt20		Spt20 family	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3386 (release 23.0)	Family	This presumed domain is found in the Spt20 proteins from both human and yeast.  The Spt20 protein is part of the SAGA complex which is a large cmplex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.	32.00	32.00	34.90	35.10	30.30	28.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.21	0.71	-4.93	32	305	2009-07-12 10:47:42	2009-07-12 11:47:42	3	4	214	0	208	305	0	201.60	29	23.78	CHANGED	ssppl.L++at.................................................p.......sSlhl+lasspa+a..................................................................s.ppshhhsYss.h.+thLcalcptplP.pthh-lL..........................pp..s...............slpFY-GCl.IlplhDa+s...................................................................t..............tt...........t..t.tp.tt...............pPcsapslL+PTstolhhDlhhhsss...................................................tphssp.hhphEucllt.sTsts................LsL-ss.s.......stpttshLp.p	.......................................................................h...tl.LcKh............................................................ssLllpLaPsphtas.....................................................................................s.scshphPYcp...pplL-alcscplP.s.Ll-lL................cc..s......................sl..Fas............GCl.Iscl+DaRp.......................................................................................................................................................................................st.psp+llL+PT....poLhsDlp.h.sss..............................................................................ttpaopc-...tLtlESpllh.ATstP................LsL-Pshs.........stpstshh...hh...................................................	0	58	93	145
+11924	PF12091	DUF3567		Protein of unknown function (DUF3567)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3056 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved EIVDK sequence motif.	40.90	40.90	50.00	47.60	32.30	30.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.88	0.72	-4.01	11	117	2009-07-12 10:52:43	2009-07-12 11:52:43	3	1	116	0	45	74	12	87.40	57	98.69	CHANGED	MQMlYsS-sasVVch.........sPDssh................ttLsptGaEIVDKpup+ElaLDGuhAEhFppclpshhpspPo.EEVDDhLspYsuLhppPVllH	..MQMIYNSsNYCVVEF................sPpss+..............tshsuGGYEIVDKNupREIFlDGplAE+FRccVcpLIps.EPol-EVD-FLGpFDoLMpQPVVlH.	0	2	20	33
+11925	PF12092	DUF3568		Protein of unknown function (DUF3568)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3573 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length.	37.00	37.00	39.00	38.70	32.50	32.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.51	0.71	-4.43	8	164	2009-07-12 10:55:55	2009-07-12 11:55:55	3	1	45	0	26	90	3	129.80	34	95.07	CHANGED	+KlhllhLhsh.slsLsuC.hlsAllsGsus.tuGsstY..lsGpYhs-l.stsacsVYsATlpAIpsspsaslpspshs.....p..psAsIsus........sKsss-slplclpKlscNsTclpIKhGshGDpttSusLhspIpcNl	.............Khhlhhlhsh.s..lsLsSC...ssullsGhu..sssuu.......s.stY..lsG...pYhhpl.stshpsVYsATLpAlpssssaslp.spshs.......s..pcApIsus........scssssshplplp+lssssT+lpIKaGshG..DpttSusLhspIppsl..........	0	15	19	19
+11926	PF12093	Corona_NS8		Coronavirus NS8 protein	Assefa S, Coggill P, Bateman A	anon	Pfam-B_2038 (Release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in coronaviruses. Proteins in this family are typically between 39 to 121 amino acids in length. This protein has two conserved sequence motifs: EDPCP and INCQ.	27.00	27.00	52.50	52.50	18.40	17.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.79	0.71	-3.74	2	88	2009-07-12 11:00:27	2009-07-12 12:00:27	3	1	70	0	0	20	0	68.90	56	96.56	CHANGED	MKLLIVhshlo.s.CI..csslQcCspNpPa.lEDPCPhtY.s-W.I+htoR....poAhLstL.....GKhlPhH..hatshs.oCpP.lpINCQsPssGuLIsRC.Y.a-...hsta+DVhVVL	....MKLLIVhshlo.s.CI..psslQcCspNpPa.lEDPC.lp.......................................................................................	0	0	0	0
+11927	PF12094	DUF3570		Protein of unknown function (DUF3570)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3745 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 396 to 444 amino acids in length.	25.00	25.00	170.60	170.20	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.54	0.70	-5.74	41	141	2009-07-12 11:02:17	2009-07-12 12:02:17	3	1	118	0	71	143	85	412.60	24	92.13	CHANGED	tlstsLshs..........ssullussstsps.....................................cl-...hthhhYpE............ps.psssstshsshc...............pshu-cp.slshchslDsloGASssssss..................h.tspt...sssapstuGtssh.t...................DTRhphssshsp..hspshphshusphSpEhDYhShuhsh.ulspshspcNTolohuhuht.Dpl....thshthpt.....t....................................s-s+pshshhlGloQlls+phlhphshshstssGYLosPY.+hlphhDss..............s.s.............................................t.hh.hEpRP-sRh+tul...hhpspatls..sssh....chpYRYasD-WuIsSHTh-scahhtlssph..h........lpPphRYYpQssAcFYp......shh.psp.s..h............s..........pahouDhRLushsuhohGlp...........hs...........hphtsthplshphthYppssshs.........G.....................................................thpshhlplshpF	......................................t......hhhshshhsts.t..sts.th.tct......................cls...hthhhYp-....................ps.psssssshsshp......................pshucct.slshchslDslouASssssss...................................t....ssths...h.uG.ts.......................................................DsRhphshshsh..hppstphshGsshSpEhDYpShGhsh.uhspshspcNTololGhuhhhDpl.psh..hssshps...................h........t......................scs+pohshtlGloQllspphhhphshshstpsGa........LosPY.+hlp..hhDss..................s..........................................................t.hh.hEphPDsRh+hul...hhpsphhls....sssl..chpYRYapDDWGlsoHTh-hchhhhlss.pa..t..........lpPphRYYsQ.ou.AcFYp.........shh.ts...s.....h...........................................................s............pahouDacLusasuhshGlt.................hs........hphttthphshphtaYppssshs........................................................................h.h...........................................................	0	28	54	65
+11928	PF12095	DUF3571		Protein of unknown function (DUF3571)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3506 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 85 to 97 amino acids in length.	25.00	25.00	25.10	59.60	21.60	17.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.79	0.72	-3.75	23	90	2009-07-12 11:05:05	2009-07-12 12:05:05	3	2	87	1	41	92	116	83.50	41	82.07	CHANGED	MuDP...LlRspDpYVVLE.PspsEphLTssEhLtaLpphLpp..h-sL.PtDLpchsolsstAp+Ll-TAC-LEl.uPGhslQWaAVRLE	......Msss...lhh.ppDpaVlLE.PspsEpFLospELht+LcshLpp..tssL.P.DLpchsolsstApaLl-osCEL-l.GsGt.hlQWYsVRLE.	0	7	27	37
+11929	PF12096	DUF3572		Protein of unknown function (DUF3572)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2130 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 100 amino acids in length.	35.20	35.20	46.70	61.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.82	0.72	-4.14	41	202	2009-09-11 14:10:56	2009-07-12 12:08:04	3	1	199	0	63	161	66	88.30	42	89.90	CHANGED	hst-sAEslAlpALuWlAus--LLshFLutTGhusssLRpsAsDPsFLuuVLDFlhhDDAhVhAFs-utGls.ppshtARtsLPGu....st.	.........sptsApslAlpALuWLAsD.c-lLsRFLAhTGlpssslRpuAp-PuFLuuVLsFlhscEssLltFC-psGhcPsthtpAhthLsGu..s.....	0	14	37	46
+11930	PF12097	DUF3573		Protein of unknown function (DUF3573)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2286 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 372 to 530 amino acids in length.	26.60	26.60	26.60	27.30	26.40	24.90	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.37	0.70	-5.85	5	128	2009-07-12 11:17:35	2009-07-12 12:17:35	3	1	33	0	12	96	0	354.20	51	73.37	CHANGED	hFpKphLIloslLshuhhsahspS.thhs...........................s.QsssSpplD+psIocLQpQIppLQuQINpL-pp.......psoNtsupFsTYSSKVsss....olsulGpoKsLussphNNphsoDIhsNlss-ssIIsLuupslGGlFspcGuIDVGNAPAITTQGQlTYLGSYSGNNTIPIGQISSNLFASTIlGQR-KFDsYSIFFGGaIEADAQsWFGSuIo+u....ssuosFsSNGQNIYLToAsLYFLANlGHYVTAsaDFsTsEsNNFuLGNAFVIFGNLDTSPaFVTVGKs.RlSVGoFGGGGPWTSGITtNFLsPGRVTNluLNYKoDThNANVTVFuopNpHAsFSsAlFYAsKhTsNIA.VGFNhGYlaDlAGAsNsSls+hh.phsahsKoVGpFN	.....................................h.Kh.llh.hhL....h.aht.S.th.s.................................Qsstup..-pptl.pLppQIppLQupIspLcpp............p.s....p.pFsTYSSKVssp.....hh..t.Gpspsl.sp.s..ss..tsclhsN.s.pps.lsLusp...tlFspsGuIDVGsAPAITTQGploYLGSYSGNNolPIGpIsSNLFASTlltQRsKFDsYSlFFGGaIcADAQhWFGosIs.s....psu.sshsuNGQNIYLToAsLY..FLuNlGHYVTAphDFsTs..-sNsFsLtsAFVIFGNLDTSPaFVTsG+s.+lSVGoaGG...GGPWTuGITtsFL.sPs+VTNl.SlNYKssshNANl.sVFuop....sp+AsFSsulFYAsp........hTsslA.lGFNhGYlaslAGAsNs.Slsp.h.phsh.scslGshN.............................................	0	7	7	7
+11931	PF12098	DUF3574		Protein of unknown function (DUF3574)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3542 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 144 to 163 amino acids in length. This protein has a conserved TPRF sequence motif.	25.00	25.00	25.00	27.10	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.34	0.72	-4.44	21	194	2009-07-12 11:23:53	2009-07-12 12:23:53	3	1	194	0	67	196	59	103.70	42	69.59	CHANGED	lps-LhFGhshssss.......sVS-A-appFlcc-VTPRFPDGLTVhDApGQW+s.ssGp..lsREsoKllhllasssssp.csslpsIRpuYKp+FpQpSVhhsspPsCVSF	.....................popLaFGhsps.sGs.......sIoss...-WppFlDcpVT..PRFsDGLTVaDAcGQWhs.ssGp..lsREpSKslhllas..s.s..s.ss..cssl-AlRpsYKpcFtQpSVhhlppsVCVuF................	0	14	27	46
+11932	PF12099	DUF3575		Protein of unknown function (DUF3575)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2229 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.  Proteins in this family are typically between 187 to 236 amino acids in length.	27.90	27.90	28.50	28.80	27.40	26.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.18	0.71	-5.21	39	605	2012-10-03 17:14:37	2009-07-12 12:36:53	3	4	114	0	65	504	70	197.20	28	78.01	CHANGED	h+phhhlh................................................hhllhhsshh............................................tuQplAlKoNlLYDA.sss.NlGsEhslu++WolslsspYNsWp..a.ucs........+ph+tahspPEhRYWh.......scpa.sGHFlGlauphGpYNh..ush...hs............phpcpR.YpG..hhaGu.GloYGYpahLuc+WslEhslGlGYsphcYcKYsssc.Cush.hspscp.sahGPTKAulSLlY.ll	......................................................................................hhhh..........................................hpspphAlKoNlLa.u.s.t.........s.........sNlGlEhs.l....u....c....+....h...olsls..s..sas.s...Wp....h....s.c...s.........+..p..h+hahl.pPEhRYWh............................................scph..sG..aFlGlau...tsup.aNh.......................ph.p.cp+Y.p.G.......h..h...Gu..GloYG.....YphhL.....u..c....+..Ws.....lEhslG...lG....YhphcY.......c.+....Y.tsh.......s......sst...h......htpt.pp...s...a....h....G....P....TKsulSllYhh..........................................	0	21	53	65
+11933	PF12100	DUF3576		Domain of unknown function (DUF3576)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2102 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 100 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.	25.00	25.00	25.60	42.20	24.50	16.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.37	0.72	-3.98	34	167	2009-07-13 12:12:39	2009-07-13 13:12:39	3	1	167	0	52	147	1293	101.70	45	60.38	CHANGED	ssluV.NpYLWpASL-sLsFhPltosDPFuGVIlTs.YusPsusscpa+.sTVaIhDssLcAcuLpVul..QspsG......tsVsssTspslEsAILoRA....RQLRlp	....s.huVNpYLWpAoL-TLSFhPlsSsDs.GGVIlT-WYusPsssscRaK.lslaIhDssLcuDulcVslhcphpps.ttWh.ssssusTspslEDtILoRA....RpLRl.s............	0	21	39	42
+11934	PF12101	DUF3577		Protein of unknown function (DUF3577)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2116 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 143 to 307 amino acids in length.	25.00	25.00	27.00	26.40	24.10	17.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.51	0.71	-4.28	18	264	2009-09-11 09:40:19	2009-07-13 13:15:57	3	2	181	0	85	234	9	132.20	44	83.97	CHANGED	ssssspspYFNLHssGlGYLNcIRcVp.........s++GpsFhACsIAALpGsoDsspYsaFDssVsGpEApcLIcRCpcAVcs-+KVLluFpluDLasDsFTasp.....Gc+pG..-suVSLKuRLlhlsWIKVDGchlYpApspssssss	.........p..tsspppYFsLpTsGIGYLsRlR-Vs.....s+cGpsFLuCsIAALs.Gss...Ds...sp.....YphFDspVuGsEApcLlpR.C.pA........l.....-.t.....c+KV.LluFRL.uDlhsDsFhhsK.....G-+tG..-....susSLKuRLl+lshIKlsGphVYpstttptt..s...........	0	8	42	68
+11935	PF12102	DUF3578		Domain of unknown function (DUF3578)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2328 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 177 to 191 amino acids in length.	25.00	25.00	26.40	26.40	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.06	0.71	-4.69	18	298	2009-07-13 12:20:20	2009-07-13 13:20:20	3	10	279	6	54	186	75	180.50	34	35.53	CHANGED	pclhspYhpt+spp.Fppp......thsphlcpcl.cplpppshlspptah.VcGSsGQGsWAclPWlulhscplTsospcGhYlVYLFssDhsslYLoLsQGhTchppph....tspsplcphsphh+shlpp..ppt..hsspIpLtsph.........hspsYEpusIthKtYshs.sl..PsccpLhpDLcpllshYpphhsph	...........................................plhp.hhpt+Tpp.http...........htpll+p.cls...cp..lps......alccc..cY...Vs.GplupG.N.aupVPWIulhDcsITp.......pTpcGaYlVYL.Fp..s-h-sl.YLoLsQGhochsc.a.........psKsthc.phu..plpspl.sp.....spp.hsssphhhupspt........hspGYspusIta+hYDls..ch.............s-..-chlpDLcchLchapplhs..s...............................................	0	17	37	44
+11936	PF12103	Lipl32		Surface lipoprotein of Spirochaetales order	Mistry J, Gavin OL	anon	pdb_2zz8	Domain	Lipl32 is an outer membrane surface lipoprotein of Leptospira like bacteria.	25.00	25.00	88.20	87.90	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.28	0.71	-4.82	4	121	2009-07-13 14:59:56	2009-07-13 15:59:56	3	1	47	9	6	90	0	179.70	90	77.15	CHANGED	shcltlPYssslsYaGYlcsuspPDuhlcG.KcAYYLYlWVPAVlsElGVRMISPsu..upPscuDhVpcuFpsshpu-.p..+aFDTaIplERhsllps-cIs.KuAKsh.hptLsssDDus-h.cp.ptupYNSLhRhcSplusPsKA............LVRGLYRIuFTTYKoGcVcGSFlAoVG....sslPGVsh	.TVKThLPYGSVINYYGYVKPGQAPDGLVDGNKKAYYLYVWIPAVIAEMGVRMISPTGEIGEPGDGDLVSDAFKAATPEEKSMPHWFDTWIRVER.MSAIMPDQIA.KAAKAKPVQKLDDD.DDGDDTYKEERHNKYNSLTRIK..IPNPPKSFDDLKNIDTKKLLVRGLYRISFTTYKPGEVKGSFVASVGLLFPPGIPGVS.P...	0	1	3	5
+11937	PF12104	Tcell_CD4_Cterm		T cell CD4 receptor C terminal region	Mistry J, Gavin OL	anon	pdb_1q68	Domain	This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalisation. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure.	20.60	20.60	20.60	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.87	0.72	-7.13	0.72	-4.36	5	89	2009-07-13 15:23:31	2009-07-13 16:23:31	3	15	45	9	23	90	0	27.50	74	6.42	CHANGED	RRRAcRMSQIKRLLSEKKTCQCsHRhQK	.........RRpAcRMSQIKRLLSEKKTCQCP..HRhQK....	0	1	1	5
+11938	PF12105	SpoU_methylas_C		SpoU, rRNA methylase, C-terminal	Assefa S	anon	PFAM-B_2024 (release 23.0)	Family	This domain is found in bacteria. This domain is about 60 amino acids in length. This domain is found in association with Pfam:PF00588. This domain has a conserved LFE sequence motif. Some members of the Pfam family SpoU_methylase, Pfam:PF00588, carry this very distinctive sequence region at their extreme C-terminus. The exact function of this region is not known.	25.00	25.00	25.60	26.50	24.20	21.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.72	0.72	-4.41	53	711	2009-07-13 15:25:21	2009-07-13 16:25:21	3	2	708	1	104	324	122	58.50	70	25.78	CHANGED	RQRpsAGhYspp..tLss-php+lLFEhuaPhlAchC+c+GhPYPtLc.-pGpIlsctsa	.....RQRQNAGMYLRENSMLPEsEQQRLLFEGGYPVLAKVAKRKGLPYP+VN.QQGEI-ADA-W............	0	14	41	76
+11939	PF12106	Colicin_C		Colicin C terminal ribonuclease domain	Mistry J, Gavin OL	anon	pdb_2dfx	Domain	Colicin is a protein produced by bacteria with Col plasmids. Its function is to attack E. coli through actions on its inner membrane ion channels or through ribonuclease or deoxyribonuclease actions. The C terminal domain is the ribonuclease domain. It specifically cleaves tRNA anticodons which recognise codons in the form NAY (N:any nucleotide, A:adenosine, Y:pyrimidine) which corresponds to Tyrosine, Histidine, Asparagine and Aspartic Acid. E5-CRD can be referred to as an RNA restriction enzyme that specifically recognizes and cleaves single-stranded GU sequences. [1]	25.00	25.00	37.10	29.80	22.10	15.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.21	0.72	-4.37	12	86	2009-07-13 15:32:11	2009-07-13 16:32:11	3	14	21	10	69	94	0	34.60	49	16.18	CHANGED	GsVssshscpssscT.PDulsppsSusVhs.psssY	.GsVlhVls-ss-scThPDSVoo.PSuoVVV.pVVVY...	0	3	69	69
+11940	PF12107	VEK-30		Plasminogen (Pg) ligand in fibrinolytic pathway	Mistry J, Gavin OL	anon	pdb_2doh	Domain	Pg is an important mediator of angiostatin production in the fibrinolytic pathway. Pg is made up of five subunit kringle molecules (Pg-K1 to Pg-K5), of which the first three make the protein angiostatin. VEK-30 is a domain of the group A streptococcal protein PAM. It binds to Pg-K2 of angiostatin and activates the molecule to mediate its anti-angiogenic effects. VEK-30 binds to angiostatin via a C terminal lysine with argininyl and glutamyl side chain residues known as a 'through space isostere'. [1]	20.80	20.80	20.90	21.10	19.20	20.60	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.87	0.73	-6.24	0.73	-4.10	8	126	2009-07-13 15:37:18	2009-07-13 16:37:18	3	14	3	12	0	125	0	16.50	71	9.92	CHANGED	DDsELcRLKNERH-HDc	..-sELERLKNERH-HDc	0	0	0	0
+11941	PF12108	SF3a60_bindingd		Splicing factor SF3a60 binding domain	Mistry J	anon	pdb_2dt7	Domain	This domain is found in eukaryotes. This domain is about 30 amino acids in length. This domain has a single completely conserved residue Y that may be functionally important. SF3a60 makes up the SF3a complex with SF3a66 and SF3a120. This domain is the binding site of SF3a60 for SF3a120. The SF3a complex is part of the spliceosome, a protein complex involved in splicing mRNA after transcription.	19.10	19.10	19.40	19.10	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.79	0.72	-7.02	0.72	-4.40	20	244	2009-07-13 15:39:18	2009-07-13 16:39:18	3	8	212	1	178	228	0	27.60	47	5.54	CHANGED	sulu..ss-.asEFYcRLcpIK-aH++aPN	..........slo..uss.FsEFYsRLKpIK-FHR+aPN....	0	61	94	144
+11942	PF12109	CXCR4_N		CXCR4 Chemokine receptor N terminal	Mistry J, Gavin OL	anon	pdb_2k03	Domain	CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1. [1]	20.30	20.30	20.50	26.60	18.90	19.70	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.39	0.72	-4.15	4	102	2009-07-13 15:43:43	2009-07-13 16:43:43	3	2	77	15	21	91	0	32.40	82	9.34	CHANGED	I.huDNhSEE.lGSGDY-shpEPCFpcENucFNR	.....IYTSDNYTEE....hGSGDYDShKEPCFREENAHFNR.	0	1	2	6
+11943	PF12110	Nup96		Nuclear protein 96	Mistry J, Gavin OL	anon	pdb_3bg0	Domain	Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is the point of curvature in the heptameric complex. [1] [2]	25.00	25.00	29.20	28.40	23.50	22.20	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.65	0.70	-5.30	36	380	2009-07-13 15:55:46	2009-07-13 16:55:46	3	13	307	11	219	392	9	259.90	30	20.01	CHANGED	s.hEphhhhLsupclpcAschAlpupsh+LAsLlo.l.usssss+p.hppQLppW+ppss..s.lspshhclYcLLuGsshhspss.t....................tlsWhpshGL+LaYupssp....slccslppatcslsp............s.....................pt..hpshhatLL+lY......sspst..........shpth...lts.shssssLch+LsWhlhplLpshshhpt.t..........................................t........DpLshsaAspL...cspGhap.AlFVlhHlssssp....Rcpsl+plLtRphptlss.t..............sp.palhpcLplPpsWIapApAlhs+sps	........................-thh.hLsspclpcAsphuhpstsh+LAhlluph..s.........s..s.......t.h+p.hptQL.tWpptph...p.............lpp..hhpla...tLLuGpsh.hptuptt.....................h.tlsWhpslul.pLWYhhssss...............olscAlptapcshps.......................t.st.PhP...Yhpt................................sstpsh.DlhapLL..pLa.................upppt................................slpph......LpP...h...sh...o................sssh..D..aRLuWh..LhpsLpulshpphs..............................................tt...s.lphsaAtpL................ps..uhap.A..lFVlh..H.lp.pttt..............................RppslpphLt+p.s.t.hhtp........................................t.phl..hppLtlPtpWlhtAtAlhtt......................................	0	79	126	184
+11944	PF12111	PNPase_C		Polyribonucleotide phosphorylase C terminal	Mistry J, Gavin OL	anon	pdb_3gcm	Domain	PNPase regulates the expression of small non-coding RNAs that control expression of outer-membrane proteins. The enzyme also affects complex processes, such as the tissue-invasive virulence of Salmonella enterica and the regulation of a virulence-factor secretion system in Yersinia. In Escherichia coli, PNPase is involved in the quality control of ribosomal RNA precursors and is required for growth following cold shock. This family contains the C terminal protomer domain of the PNPase core.  The function of the C terminal protomer is to catalyse phosphorolysis through its two active sites. [1]	25.00	25.00	27.20	27.20	24.70	23.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.79	0.72	-4.76	16	611	2009-07-13 16:01:04	2009-07-13 17:01:04	3	3	604	16	52	368	0	38.90	67	3.77	CHANGED	Essphu-WQcspahFcGKGuAGtHSAsspspussT+sps	...EuP+HSDWQ.RPoFsFEGKGAAGGHoAT+HASAsPsRPQP..	0	2	13	34
+11945	PF12112	DUF3579		Protein of unknown function (DUF3579)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2027 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 98 to 126 amino acids in length. This protein has a conserved FRP sequence motif.	25.00	25.00	28.40	28.10	19.70	19.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.98	0.72	-4.08	19	284	2009-07-13 16:43:08	2009-07-13 17:43:08	3	4	249	1	88	221	35	93.20	46	62.29	CHANGED	hpsp....scchhIpGlTppGKsFRPSDWAERLsGlhupF....psst........+hsYSPastPss.hsGlKCVhVctcL+-hEPhAacFlhNFA+DNcLplh-.tshh	...........h...pspchhIpGlTp.sGKpFRPSDWAERLsG..l..husF....psss...........+lpYS.aV.+Psl..lssl+CVhVDp+LcshpP.AFcFlhsFApDNsLpVh-s..h............	0	18	51	68
+11946	PF12113	SVM_signal		SVM protein signal sequence	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2829 (release 23.0)	Motif	This region is presumed to be a signal peptide sequence found in Sequence-variable mosaic (SVM) proteins [1]. This domain is found in phytoplasmas. This presumed signal sequence is about 30 amino acids in length.	31.70	31.70	34.10	34.10	28.70	27.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.46	0.72	-4.12	32	70	2009-07-13 16:58:34	2009-07-13 17:58:34	3	1	15	0	53	69	0	32.70	50	22.02	CHANGED	MFKLKsphhll..pIhLFlhLGLhhIsNN.ppVMAM	..MFKLKNphpll..sIhLFhhLGLhhIsNN.ppVMAM....	0	16	17	31
+11947	PF12114	Period_C		Period protein 2/3C-terminal region	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2037 (release 23.0)	Family	This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with Pfam:PF08447.	25.00	25.00	49.90	27.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.43	0.71	-4.70	24	250	2009-07-14 11:56:36	2009-07-14 12:56:36	3	7	74	0	85	198	0	189.60	38	17.03	CHANGED	ssDuhSsSS-LhshlLpEDutS............usuSusSsS..s............tpsS................sussoSpoSpYFGShD.SSEsscps+pstssp.....................ptphh+hVhpDPlWlhhssss-plMMTYQlPsRsh-pVL+ED+EKL+php+.QPpFoc-QKcELucVHsWlpptslPptlslpsClsCpspsss..............shctchpphphsch	...................................................................................ppDu.SsSS-LLplL.......Lp..E..DupS....................uT.GSusSuShssstst....................................uoG.Sts.sssost.............................ssuSpSSpoSKYFGShD..SSEssppsppststp....................tcphl+h.VLQDPlWLlhAss-ccVMMTYQlP.s.RshpsVL+ED+E+L+shQ+pQP+Fo--Q+cELupVHsWl...ppssLPptlslp.sClsCpspsps.............................s.....................................	0	10	19	41
+11948	PF12115	Salp15		Salivary protein of 15kDa inhibits CD4+ T cell activation	Assefa S	anon	PFAM-B_2039 (release 23.0)	Family	This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.	27.80	27.80	28.00	30.10	27.60	26.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.39	0.71	-3.87	44	93	2009-07-14 12:43:31	2009-07-14 13:43:31	3	1	6	0	7	99	0	128.00	23	94.54	CHANGED	lphhh..........lhlhhslsh..................................sptpspsss.........................slttphsphhsssc...phtpplhphCpp.......................ptlssphls..apsCoahCt.........ssttsphphp....Ls-GhPCG....pspsC.ppGpCss..........h.sC	......................................lhhhhshsh........................................s...ttpp................................s.shphPshhsshp....shhspltptCspt...................p.htsIsshphc...hpsCphtCp.......tpspp.ssplohs.............Ls-GpPCu....sppsC..pscCstp.......ssC..............	0	7	7	7
+11949	PF12116	SpoIIID		Stage III sporulation protein D	Assefa S	anon	PFAM-B_2045 (release 23.0)	Family	This stage III sporulation protein is a small DNA-binding family that is essential for gene expression of the mother-cell compartment during sporulation. The domain is found in bacteria and viruses, and is about 40 amino acids in length. It has a conserved RGG sequence motif.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.64	0.72	-4.05	19	411	2012-10-04 14:01:12	2009-07-14 14:22:57	3	3	388	1	93	317	10	77.20	61	88.65	CHANGED	+-Y....IE-Rsl-lupYIlEs+ATVRpsAKsFGVSKSTVHKDlTERL.pINPpLApcV+plL-hNKAERHIRGGpAT+pKYpctc	..............+-Y..IcERslclupYI.l-s.+..tT.VRthAKtFGVSKSTVHKDlT..E..RLPcINPcLApEVKcILDh.....p.....Ku.RHlRGGcATK.KY+c..p................................	2	48	76	82
+11950	PF12117	DUF3580	DUF_B2046;	Protein of unknown function (DUF3580)	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2046 (release 23.0)	Family	This domain is found in viruses, and is about 120 amino acids in length. It is found in association with Pfam:PF01057.	25.00	25.00	56.30	56.20	22.50	17.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.97	0.71	-4.16	6	117	2009-07-14 14:37:12	2009-07-14 15:37:12	3	3	31	0	0	122	0	114.40	62	17.73	CHANGED	t+WGKVPDWSENWAEPKlpTPINSlGSh+Ssppos+STPLSQNYALTPLsSDL.tDLALEPWSTPsTPVAsTlpspNTspuGspu.QsuQtSPTWSEIEsDLRACFopEpLcoDFp-..sLD	........HHWGpVP-WsEpWtEPKlQTPINoPss.pslpTos+ooPtspNYshTPlppDL.lsLALEPWSpPsTPshpssptpsst.sssh+....psSPTWSEIEsDlRAhFsppplpps........s..	0	0	0	0
+11951	PF12118	SprA-related		SprA-related family	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2057 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are typically between 234 to 465 amino acids in length. There is a conserved GEV sequence motif.Most members are annotated as being SprA-related.	27.30	27.30	27.40	27.40	26.80	27.20	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.99	0.70	-5.09	40	267	2009-07-14 15:26:22	2009-07-14 16:26:22	3	4	261	0	76	193	40	227.00	38	76.53	CHANGED	sl.ssuhsshsstssss.sttshtt.t.......................................................................sststsssssspsss..........................................................................s...........ssssstpscp.......................spppsppppttss...........................pp.s..tppphp.p..plpcLppRDpEVRsHEQAHsulGGpaA.GuPoasYppGPDG++YAluGEVsIDlS.lsGDPpATIpKMppVpAAAhAPA-PSutDhpVAApAtpphspA+uELsppcpppssptppspt...........ttpsp.pshp..pppp.phsspsptst................t.lp	............................................................................................................................................................shshhsspsthsp......................................................................................................................................................................................................................................................................................................pppsppppp.p.s.pp.ppspppps.pps.....................p.hs..t.tscL.s.p.pphpQVcELpuhD+pV+AHEtAHtAAG.Gsh.A.GusSFoYp+GPDsphYAsuGEVsIchpp.ussP..EtTIspucQltAAAhAPADPSsQDh+VAAs.AtphphEARAE.ht..c...+s..pcsp..cppppsp.........ttppp.p.ps.t.hpp.p..............s.p.......................................	0	31	54	66
+11952	PF12119	DUF3581		Protein of unknown function (DUF3581)	Assefa S	anon	PFAM-B_2081 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are about 240 amino acids in length.	25.00	25.00	47.40	47.10	20.70	18.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.34	0.70	-5.12	22	187	2009-07-14 15:30:18	2009-07-14 16:30:18	3	1	183	0	36	129	22	211.70	61	90.92	CHANGED	MFLssYaspps..splslospQAScFAKplAsDFNPIHDsDAKRFCVPGDLLFAllLscaGLSppMpFcFsGMVucsltLpF.spssssphslsDppsKsYLcVpRuG-sopspshIEshl+sYVsFSGhNFPHlLlPLMcp+pVMINPsRPLVIYESMSh-Ls...pLDhs.pssLcLsssslcl-GKRGsVsLpFpLhsssclVGoGhKcLllSGLRsY-pcs	...MFLosYaSpps.....p.....phpFTRpQAS+FAKtVAGDFNPIHDcDuKRFCVPGDLLFAllLpK.GlSQKM+FcFoGMVuDGVsLplps.c.spcE.uVsDssGKpYL+hSRcG-Vs+ssAhIEpllpsYVpFSGhNFPHIMVPLME-pQhMINspRPLVIYESMpl-Fo...R...LDls..cP-V-FsGAoh-V-GKRGhVTLsFsh+-sGplVGcGlKRMVsSGL+PYDQt.t...............	0	6	15	27
+11953	PF12120	Arr-ms	DNApol_Rpb2_rif; RNApol_Rpb2_rif;	Rifampin ADP-ribosyl transferase	Mistry J, Gavin OL	anon	pdb_2hw2	Domain	This protein is found in bacteria. Proteins in this family are typically between 136 to 150 amino acids in length. The opportunistic pathogen Mycobacterium smegmatis is resistant to rifampin because of the presence of a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). Arr-ms is a small enzyme whose activity thus renders rifamycin antibiotics ineffective [2].	25.00	25.00	41.70	41.30	22.50	20.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.17	0.72	-4.07	15	184	2009-11-19 18:25:00	2009-07-14 16:38:57	3	4	154	1	54	158	11	99.60	62	64.61	CHANGED	PFaHGTKADLpsGDLLpsGapSNYpcs.+hhNHlYFTuTLDAAsWGAELAs....G-G+sRIYlVEPTGsFE-DPNlTDKKFPGNPTRSYRSpcPLRlVGElTcW	..PFaHGTKAcLtlGDLLssGahSNacss.+hhsHIYFTAhh-uAsWGAELAh............u-G+.sRIYIVEPTGsFEDDPNlTDKKFPGNPT+SYRopcPLRIVGElpDW..........	0	20	40	51
+11954	PF12121	DD_K		Dermaseptin	Mistry J, Gavin OL	anon	pdb_2jx6	Domain	This protein is found in eukaryotes. Proteins in this family are typically between 30 to 76 amino acids in length. This protein is found associated with Pfam:PF03032. This domain is part of a dermaseptin protein which is used as an antimicrobial agent. The full protein is almost completely defined in an alpha helical domain. It creates high levels of disorder at the level of the phospholipid head group of bacterial membranes suggesting that it partitions into the bilayer where it severely disrupts membrane packing.	20.90	20.90	20.90	22.10	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.06	0.72	-6.41	0.72	-4.01	14	62	2009-07-14 15:43:20	2009-07-14 16:43:20	3	2	15	2	0	61	0	24.50	56	52.07	CHANGED	uLWssI....Kphu.pA...AGKAALsAVs	.uLWpslh...KphG.cA........AGKAALGAVs.......	0	0	0	0
+11955	PF12122	DUF3582		Protein of unknown function (DUF3582)	Assefa S, Bateman A	anon	PFAM-B_2087 (release 23.0)	Family	This domain is found in bacteria, and is approximately 130 amino acids in length. It is found associated with Pfam:PF01694. There is a conserved ASW sequence motif. This domain has a single completely conserved residue F that may be functionally important.	22.00	22.00	22.00	22.20	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.48	0.72	-4.03	32	749	2012-10-01 21:59:08	2009-07-14 16:54:12	3	2	745	15	96	340	17	98.80	56	35.72	CHANGED	MlclhslsNsRhAQAFlDYhtsps.Ichplhs.....pspu.hslalh.ccpphspsptElppFlpsP...tcs+Y.tASW-sGsTps.phc.Yps..o......hlst..h...hspAGPlTLs	.............MhhITSFuNPRlAQAFVDYMATQG.VlLTIQQ.................csQo...DlWLA.DESQAERVRuELARFLENP...uDPRYLAASWQuGcTsS.GL+.Y+Ra.P......FhAsL.....RcRAGPVThl.....................................	0	16	36	66
+11956	PF12123	Amidase02_C		N-acetylmuramoyl-l-alanine amidase	Mistry J, Gavin OL	anon	pdb_2ir9	Domain	This domain is found in bacteria and viruses. This domain is about 50 amino acids in length. This domain is classified with the enzyme classification code EC:3.5.1.28. This domain is the C terminal of the enzyme which hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.	21.40	21.40	21.70	26.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-7.91	0.72	-4.32	16	260	2009-09-10 17:34:38	2009-07-14 16:57:45	3	4	95	2	9	151	0	44.60	42	18.36	CHANGED	phshpu+llhps..sGLsYh.Tcshss.spLc+hptWLDp+...GWaYEh	...pLthsuphIlps..-GLsYhlT-spss.spLcthTsWLDp+...GWaYEh.	0	0	4	4
+11957	PF12124	Nsp3_PL2pro		Coronavirus polyprotein cleavage domain	Mistry J, Gavin OL	anon	pdb_2kaf	Domain	This domain is found in SARS coronaviruses, and is about 70 amino acids in length. It is found associated with various other coronavirus proteins due to the polyprotein nature of most viral translation. PL2pro is a domain of the non-structural protein nsp3. The domain performs three of the cleavages required to separate the translated polyprotein into its distinct proteins.	25.00	25.00	29.60	100.60	24.50	18.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.02	0.72	-4.41	5	173	2009-07-14 16:00:46	2009-07-14 17:00:46	3	5	66	2	0	152	0	65.90	97	1.12	CHANGED	SEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTlESPlEFHLDGEVLPLDKLKSLLS	SEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLS.	0	0	0	0
+11958	PF12125	Beta-TrCP_D		D domain of beta-TrCP	Mistry J, Gavin OL	anon	pdb_2p64	Domain	This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with Pfam:PF00646, Pfam:PF00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein.  Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.	25.00	25.00	26.20	26.30	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.00	0.72	-4.35	6	176	2009-07-14 16:02:24	2009-07-14 17:02:24	3	10	86	3	91	159	0	39.60	79	7.41	CHANGED	hcYFspWSEu-QVDFVEaLLSRMCHYQHGpINuaLKPMLQ	.....lKYF-QWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQ	0	20	27	54
+11959	PF12126	DUF3583		Protein of unknown function (DUF3583)	Assefa S	anon	PFAM-B_2092 (release 23.0)	Family	This domain is found in eukaryotes, and is typically between 302 and 338 amino acids in length. It is found in association with Pfam:PF00097 and Pfam:PF00643. Most members are promyelocytic leukemia proteins, and this family lies towards the C-terminus.	22.70	22.70	23.50	24.40	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-12.04	0.70	-5.36	3	98	2009-07-14 16:17:51	2009-07-14 17:17:51	3	7	36	0	23	120	0	236.60	58	40.35	CHANGED	LDTMTQsLQEQDRTFGAAHAQM+SAIGQLGRARADTEEhIRERVRQVVAHVpAQERELLEAVsARYQRDYEEIAGQLGRLDAVLQRIRTGSALVQRMKLYASDQEVLDMHuFLRKALCpLRQEEPQSL+AsV+TDGFDEFKVRLQDLlSCITQGpDAAVS++ASPEAASTPRD.....PlsTDsPE-l.p......sQhQA.tL......AhVpsVPGAHPVPVYAFShQsPohREEuSNTTTuQKRKCSQT-CPRKlIKMESEEGcEuRLApSSPEQPRPSTSKAVSPPHLDGPPSP+SPVlccElhLPNSNHVTSDsGETEERV..................VVISSSEDSDAENss	................LssMTQsLpEQ-tsFsusHAQM+uAluQLs+sRu-TEELIRtRVRplVsHlpAQE+ELL.EuVpsRYQRDYcEhAucLuRL-AVLQRIRsGusLVpRMKpYASDQEVLDMHuFLRpALs+LRQ.EEPQsLpAsV+TDG..F-EFKlRLQDL.SCIT..QGpsuuss+p.AsPEusssPp-.....shss-....................................................................-sosTssspKR.Ksspsp..CsRKlIKMESpEt.pEsRLApSSPEQPtPSTS+AsSPP+LDG.sss.cSss.tp-h...sssNHssu.s.s...u.Estcpl..................hllusSccsct....s.................................................................	0	3	3	7
+11960	PF12127	YdfA_immunity		SigmaW regulon antibacterial	Assefa S	anon	PFAM-B_2114 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are about 330 amino acids in length. The operon from which this protein is derived confers immunity for the host species to a broad range of antibacterial compounds, unlike the specific immunity proteins that are linked to and co-regulated with their antibiotic-synthesis proteins.	26.70	26.70	26.90	39.30	25.10	26.60	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.00	0.70	-5.53	22	608	2009-07-15 08:13:42	2009-07-15 09:13:42	3	2	588	0	119	350	208	312.90	69	96.50	CHANGED	lhhlllsslhllhlhlhFs.FlPhs..LWIoAhuuGVclulhsLlGMRLRRVsPppIVpshIpApKAGL.....c.lssspLEAHYLAGGNVspVVcALIAAp+As.IsLsFcRAsAIDLAGRDVLEAVQhSVNPKVI-TP........slsAVAKDGIpL+sKARVTVRANIc+LVGGAGEETIIARVGEGIVooIGSussHKpVLENPDpIS+sVLsKGLDuGTAFEILSIDIADlDVGcNIGAcLQsDQAEADKclAQAKAEcRRAMAVApEQEMpAhlpEMRAKVVEAEAEVP+AhApAhRcGpl.GVMDYYphpNlpADTpMR-uIu+tu......cs	.......ls.hlllslllllhL.llh.Fo.F.V..P..lG..LWISALAAGV+VuIh.TLVGMRLRRVsPp+llsPLIKApKAGL...........s.losNQLEuHYLAGGNVDRVVDALIAApRAs.I-LsFERAAAIDLA....GRDVLEAVQMSVNPKVIETP........hluuVAhsGIE.VKAKARlTVRANIsRLVGGAGEETIIARVGEGIVSTIGSScpHpcVLENPDsISKTVLsK.GLDuGTAFEILSIDIADVDIG.....KNIGAcLQT-QApADKpIAQAKAEERRAMAVApEQEMKA+VQEM+AKVVEAEuEVPlAMAEALRsGNl.GVhDYYNhKNIpADTsMRsuIuKts.ct...........................	0	66	99	112
+11961	PF12128	DUF3584		Protein of unknown function (DUF3584)	Assefa S, Bateman A	anon	PFAM-B_2142 (release 23.0)	Domain	This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.	28.70	28.70	28.70	28.70	28.40	28.50	hmmbuild  -o /dev/null HMM SEED	1201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.17	0.70	-13.81	0.70	-7.23	10	142	2012-10-05 12:31:09	2009-07-15 13:32:20	3	7	123	0	45	146	29	971.80	22	91.34	CHANGED	ILIDoa..lp.GpV.ELsLsGHTplsGTNuuGKTTLhRLlPlFYGEtPS+lVsps.tRcsFs-aYLP+-SShllYEYpR.sG.QLCpsVhspt.uDG+GVpYRFIcuGYcpshFlsupptthhtshossElt+phRpsGhssSphLs.hccYRuIIQN-Rohh...GpcppELRsLAppFSLssu-pslpHIDKlssushsKptch-slKsMlsAIhp-...Dsssssppp...lsppclpsWlpDhpthpulpplpschcclpp-aspLpSlhh+LptL+stlhucppplppcQp-ppstppchcpplcpL--phpEspcchsp-lSstcuclstpcscL-tl-cp+tsapDsDlEphptDh-plPphcs-hpplptplctlpsptpclppca-cppptlcppppcclpshcsc.tpslREp+sct...+sstccshpuLEuphppQhcttppchsccphclcpplschctphsssshosEphtslpts-pclccAcEphppupsshppLpscppph+pcRDpApctLpcusppLpch+sphp-lcpQLhPpusSLlcFL.RsE..AssWccsIGKlIssELLcRTDLsPphspus..s.s..sLaGlpLDLpsl-sP-astsEp......pLRp+Lsth-csLpoApspppptEcpLsplNspl-ptpcslscAppuhcpscpcLpRLpsppcshpc+lppAlpc++ppsppplspLcpplKtLpccppsalcphc-chpEtphppptthpsV.ushDsQlspLpptlputcsss+Aclcphccthcs-LpspslDspsltcLcpclcsLcppIppspsccpclpcYcsahpcsWhp......c+spLttplpslcsuhp-LppcLsptppsh+pctpcLppppcAs-cthsplsEslp.pl+shhcpL.AplphstssspAs....hplu.phcth--hpppccRLtsslcpalE+Fcsll....sc+SGSsLhEsWp+h.ppcsshlu-+ul...p.hch..l.hlpplhsll..ssQpppulh-hsslhusslscFYpsLsshsRRIcohS++Lo+cVssptphEulu-lsVclpo+l-EL-aWssLctFsc...sFcpWpcp..-Ghs-lPc-phssuMpRlsshLss.uuhshulssLl-lElsLpEsGpclhIRN-+QLpcsSSpGhoYLIlhphhlGFsphLRG..cusspIpWPVDELGpLctsNlc+LhshhssNpIolLSAhPssDsclLsLFp++Yhlcc	...................................................Eltlc.GpsphhGTpusGKoTl.Rhl.hFY.st..p+l.l.pp..+cuFpcaYhPhssSaIlYEh.+tsG.....hhpslht.t.spu..tlp.aRFls.tsap.p.....alpppp.....hshs.tphhpphh.t..t.slthothls.hpcYRsII..sstp............t.chh.h..tpaulhp..utpphppI.+.hh.psl.hspchch-hlKp.hlht..h.p-.......sh......ppp.........p.pchptWhp...c.p......h.....p..t..h...........hp.ph.ppltpt........hppl.th.p.plt.thttthtts.p.ttpp...hppp.pchptphpphpcp...hp...p.ppchppchsthptslsthpppLctlpppctta.tpts.Ipphhtc.h.pph.....phppch....pplppphphhspphp-lpstapt...h...hppltpph....p.......p........hpt....hptp.....sph....ppphtpt........tpttcpphpthppph.......ppphp..ttht.ph...p..ppp.ph.......p..p.htph..ch.....p...h....p...phph..pp-th..phth.......hc......ttl..pp....t.p.p....ptp....ph.ptt...h..p...p...h..p....tp.....pph.ptp....hp........pt.t...p....tl.pt....h....p.phpp........h....ptpltplpthL.sp..psoLhpaL.ppp....t.sWcps.lGKVls.c.l.Lhp..p-LpPphstt.....s....t.........shaGlp....l..s....Lpsl.....p.....h.....s.....phhtpcp.......phptp...hpthpp.th.tp....h.p.....p.....t....pp.h....cppl.tt....h.pt....p....lpp....hpp.......ph....s.tp.......t...thc.p..p.t....ch....pphhspp....pp.ppchppthptphpphtpplpphptplpphppphpphhp.t....ccphtphc.....phpt.hpph.sthcpphttlptphpp....tppphppphpthcp.hp...p-L.pupGsD.ttpltphcppltplppplphhcppcs.lhc....Ypc.hppha.........tp.phppphtth.cpthpphppphpthtpphptphpph.ppphpt.ctt.tphp..p.hp.......t.p.hh.p.....tp...h.........s....pt...t.php..........ht...phh.pphpph...h.ph...tt...hhtp...hpphht.phpt.h.......st...th.c....h.t...........t...sct...........hph........h..l.p.hhp.........sp..p.l.p.hp..h..h.pl.tt.hthhtphptcltt.stclsp...th.t.....hthlt....p...thp.h..sp.p..h.t.....h...h..lp.h.t.......th.....t.h..t.......t..thst........hh..htphhp..h.t..tt.....thtltphhclphplhEssp.c.hhhh..cpltpsuSpGhshLlhshh.lhhhphh+t.....ts.....phtlph.hDElGpLp.pNlptlhphhppppI.llsu.P.s..................................................................................................................................	0	8	23	38
+11962	PF12129	Phtf-FEM1B_bdg		Male germ-cell putative homeodomain transcription factor	Assefa S	anon	PFAM-B_2140 (release 23.0)	Domain	This domain is found in bacteria and eukaryotes, and is typically between 101 and 140 amino acids in length. Phtf proteins do not display any sequence similarity to known or predicted proteins, but their conservation among species suggests an essential function. The 84 kDa Phtf1 protein is an integral membrane protein, anchored to a cell membrane by six to eight trans-membrane domains, that is associated with a domain of the endoplasmic reticulum (ER) juxtaposed to the Golgi apparatus. It is present during meiosis and spermiogenesis, and, by the end of spermiogenesis, is released from the mature spermatozoon within the residual bodies [1]. Phtf1 enhances the binding of FEM1B -feminisation homologue 1B - to cell membranes. Fem-1 was initially identified in the signaling pathway for sex determination, as well as being implicated in apoptosis, but its biochemical role is still unclear, and neither FEM1B nor PHTF1 is directly implicated in apoptosis in spermatogenesis. It is the ANK domain of FEM1B that is necessary for the interaction with the N-terminal region of Phtf1 [2].	21.10	21.10	21.10	21.20	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.92	0.71	-4.88	3	198	2009-07-15 12:34:29	2009-07-15 13:34:29	3	2	71	0	83	159	0	143.60	60	22.68	CHANGED	S+lcDAluWYQKKIGAYDQQIWEKSIEQ+pIKGL+NKPKKsGHlKPDLIDVDLVRGSTFAKAKPElPWTSLTRKGlVRVVFFPlFu+WWlQVTShRIFVWLLlLYhLQVIAlVLYsh.......sQp.HIVslSEVLGPIsLMLLLGTVHCQIVSTphs+PssssG	..................p.p-hlsWYQKK..IGAYDQQIWEKSlEQ.ppI.........K......Gh....+NKPKKhuHlKPDLIDVDLlR..GSsFAKAKPE....PWTSLTRKGlVRVVFFPhF.pWW.lQVTSh.hIFhaLLlLYl..hQ.VhAlVLah...........................................hs......lsloEVlGPlhLMLLlGTVHCQIVSTphs+sshss...............	1	14	21	46
+11963	PF12130	DUF3585		Protein of unknown function (DUF3585)	Assefa S	anon	PFAM-B_2156 (release 23.0)	Domain	This domain is found in eukaryotes. This domain is typically between 135 and 149 amino acids in length and is found associated with Pfam:PF00307.	23.20	23.20	23.30	23.70	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.74	0.71	-4.33	25	600	2009-09-11 08:12:16	2009-07-15 13:54:22	3	17	92	0	329	593	0	135.50	35	15.02	CHANGED	hhsspplpp-LpplEpp.csLEtc..GVtlE+pLRst.t.............sc......p--pLhh-WFpLlpcKshLlRREuELhhhtpphpLEccpspLcpELRthhuht-tpKTpt-cp+EctLlpcllplVppRstlVcsL-pcRlREpcEDcplcp	..................................................tp.lptplptlEpp.ctl-tc..ustlEctLRstht................................spp......p--plht-WFpLlpcKssLlRc-sE.............Lhhh.t.c..-..hcLE.c+.tpLppELRphh.sh..t.......-.......t.p..KTptc....cp+Ep.tLlpcllplVppRDtLVppL-p.....pRh..p.-tEEDp.ht.t.............................................	0	63	93	196
+11964	PF12131	DUF3586		Protein of unknown function (DUF3586)	Assefa S	anon	PFAM-B_2164 (release 23.0)	Family	This domain is found in eukaryotes. This domain is about 80 amino acids in length and is found associated with Pfam:PF08246, and Pfam:PF00112.	25.00	25.00	27.50	27.20	24.00	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.91	0.72	-10.06	0.72	-3.93	16	127	2009-07-15 13:00:10	2009-07-15 14:00:10	3	3	28	2	21	137	0	77.40	43	21.85	CHANGED	supuPoPsP.oTts......PtssslhQhhChDhtCpcGCpcsslPsspCl.hsGGGSshspCssppVhhpsY.pSscCoGs	....................s.s.usTPsPoTpopppA....Pp.sshhsQhhCTDttCppGCcpssls.TspCl.ssuGuSuhssCGspplp.psY.oospCoGs........	0	16	21	21
+11965	PF12132	DUF3587		Protein of unknown function (DUF3587)	Assefa S	anon	PFAM-B_2181 (release 23.0)	Family	This protein is found in viruses. Proteins in this family are typically between 209 and 248 amino acids in length.	25.00	25.00	40.90	40.40	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.48	0.71	-5.08	52	74	2009-07-15 13:11:26	2009-07-15 14:11:26	3	1	7	0	0	73	0	182.50	31	81.44	CHANGED	ppstsss.s.s...........pt.hlPhchl..hhhucFlpFt-atphlpshhPptt.s....lptpLap.hST+phpssFlNGKpLpIcYNFDspRhcc-RlLIsl-oLlPlFGGlh...ss.shcpFsolscLpsFVchcVHLstCS.shpa.ASCsC..HLhsspt.t..........pthspP....sssCpps.HFHHaCupHVttWLphaLtssIlh+Esp.ph.ascphsc	.....................................htt....................s..phh..h.hsphhph.ph.phht.hhsptt.s....lptpLap..hST+phpssFlNGKpLclcYNFDssRhcc-Rl.LIslcoLhPlFGGlh.......ss...shcpFsolsclpsFlctcl+LstCo.shpa..A.oCsC..+hhspptp....h.....pthhps..........sstCpht.HFHHaCspHVttWLphaLtshIhhpEsp.thhtp...................	0	0	0	0
+11966	PF12133	Sars6		Open reading frame 6 from SARS coronavirus	Assefa S, Bateman A, Coggill P	anon	PfamB-2188 (release 23.0)	Family	This family is found in Coronaviruses. Proteins in this family are typically between 42 to 63 amino acids in length.	27.00	27.00	63.50	63.30	17.90	16.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.93	0.72	-4.29	6	86	2009-07-15 13:35:43	2009-07-15 14:35:43	3	1	82	0	0	15	0	57.60	96	98.29	CHANGED	MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVlISSIVRQLFKPLTKKNYSELDDEEPMELDY	MFHLVDFQVTIAEILIIIM+TFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDY.	0	0	0	0
+11967	PF12134	PRP8_domainIV		PRP8 domain IV core	Mistry J, Gavin OL	anon	pdb_3enb	Domain	This domain is found in eukaryotes, and is about 20 amino acids in length. It is found associated with Pfam:PF10597, Pfam:PF10596, Pfam:PF10598, Pfam:PF08083, Pfam:PF08082, Pfam:PF01398, Pfam:PF08084. There is a conserved LILR sequence motif. The domain is a selenomethionine domain in a subunit of the spliceosome. The function of PRP8 domain IV is believed to be interaction with the splicosomal core.	25.00	25.00	34.00	33.00	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.53	0.70	-5.01	14	350	2009-07-15 15:36:11	2009-07-15 16:36:11	3	45	291	12	240	338	7	220.60	76	10.05	CHANGED	EsaLNSpNYuELFuNps.paFVDDTNVYRVTlHKTFEGNlsTKPlNGslFILNP+oGQLFLKVIHTSVWAGQKRLuQLAKWKoAEEVsALlRSLPhEEQPKQlIVTRKuMLDPLEVHh.LDFPNIsI+sSELpLPFtuhhKl-KluDlVLKAsEPpMVLFNlYDDWLc..slSsaTAFSRLILlLRuL+lNtE+s+hIL+PshsllTpspHlWPoh.oDppWlcVElpL+DLILsD	........................EPaLsSQNYuELFSNQI.hWFVDDTNVYRVTIHKT......FEGNLT.T.KPINGAIFIFNPRTG.....QLFLKIIHTSVWAGQKRL.GQLAKWKTAEEVAALIRSLPVEEQPKQlIVTRKGMLDPLE...VHL.LDFPNIlI+GSELQLPFQAshKlEKhGDLILKATEPQMVLFNLYDDWLK..oISSYTAFSRLILILRALHVNs-+sKlIL+PDKTslT.psHHIWPoL.oDE-WIKVElpL+DLILsD............	0	89	137	200
+11968	PF12135	Sialidase_penC		Sialidase enzyme penultimate C terminal domain	Mistry J, Gavin OL	anon	pdb_2vo8	Domain	This domain is found in bacteria and eukaryotes, and is about 30 amino acids in length. The protein from which this domain is found is a sialidase enzyme which is used by virulent bacteria as a toxin. It is the penultimate C terminal domain.	20.40	20.40	21.20	21.80	20.00	18.50	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.65	0.72	-6.69	0.72	-4.22	23	64	2009-07-15 15:38:49	2009-07-15 16:38:49	3	6	14	1	18	69	0	24.80	37	4.57	CHANGED	hsDsElass-pphppNcEIYsLspI	....sDsElYtsEphhphNpElasLspl.	0	2	6	18
+11969	PF12136	RNA_pol_Rpo13		RNA polymerase Rpo13 subunit HTH domain	Mistry J, Gavin OL	anon	pdb_2waq	Domain	This domain is found in archaea, and is about 40 amino acids in length. It has a single completely conserved residue E that may be functionally important. It is found in the archaeal DNA dependent RNA polymerase. The domain is a 'helix-turn-helix' (HTH) domain in the Rpo13 subunit of the RNA polymerase. This domain is involved in downstream DNA binding, and the entire subunit has also been implicated in contacting transcription factor II B.	25.00	25.00	33.50	33.50	18.50	17.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.13	0.72	-4.26	7	23	2009-07-15 15:39:56	2009-07-15 16:39:56	3	1	23	4	11	17	0	46.10	56	46.09	CHANGED	cEtth.EE-EEsEhss....lslpslEhhh+sTElW-pLlpGcl	...............t.EEpcVE.....EssE-EhPp....LSIQDIELLMKNTEIWDsLLsGKI	0	5	5	9
+11970	PF12137	RapA_C		RNA polymerase recycling family C-terminal	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2201 (release 23.0)	Domain	This domain is found in bacteria. This domain is about 360 amino acids in length. This domain is found associated with Pfam:PF00271, Pfam:PF00176. The function of this domain is not known, but structurally it forms an alpha-beta fold in nature with a central beta-sheet flanked by helices and loops, the beta-sheet being mainly antiparallel and flanked by four alpha helices, among which the two longer helices exhibit a coiled-coil arrangement.	26.80	26.80	27.80	27.80	26.40	25.90	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.95	0.70	-5.62	50	1007	2009-07-15 16:36:59	2009-07-15 17:36:59	3	5	973	2	150	632	98	352.20	58	38.01	CHANGED	pDIpIHVPYhcsoAQphLhcWYccGLNAFpcTCPsGpslacpatppLpshLt..ss....spssh-pLlppopptpppL+spLEpGRDRLLELNSsus-pAppLs-sItppDs.sspLssFhhplFDhlGlcQE....Dpu-sullLcP.....o-+Mhsss.aPGL..s...E-GhTlTF-RcpALuREDhpFloWEHPhlpsuhDllhou-hGsoululLcNcuLPsGTlLLEhlasl-upAP+sLQLsRFLPsTPlRlLlDppGssLusplsa-shscpLpsls+phApclVpthpsplcpllppu-phupsphptllppAppphpppLssElpRLpALpsVNPsIRp-EI-tLcppppphhshLspAplpLDAlRllVss	................+DIQIHVPYLEcTAQulLsRWYHEGLsAFEcTCPTGRslYDuhhscLIsh...LAuP......pps-uaD-LIcpsRcp+-uLKAQLEQGRDRLLElHSNG.GE+AQtLA-u......Ip.................EQDs...DTsLlsFAhsLFDIlGIsQ-....DRG.-N...hIVLTP.....SDHMLV..PD.FPGL...s..EDGhTI..TFDR-sALuREDsQFITWEHPlIRsGlDLILSGDsGooslSLLK.N..KALPVGTLLlELlYVVEAQAP.......K.........pL.........QLsRFLPPTPlRh.L.L.Dc.....NG.NNLAuQVEFEoFNRQL..su..VNRHouSKL.....VsAV.Qp-VHsllphGEsplEppAcuLI-sA+p-A-pcLouELuRL..c.AL..+.AVNPNI.R.DDElsAl-spRpplhpsLsQ.AuaRLDALRLIVVs..........................................	0	35	65	113
+11971	PF12138	Spherulin4		Spherulation-specific family 4	Assefa S	anon	PFAM-B_2198 (release 23.0)	Family	This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 250 and 398 amino acids in length.  There is a conserved NPG sequence motif and there are two completely conserved G residues that may be functionally important. Starvation will often induce spherulation - the production of spores - and this process may involve DNA-methylation. Changes in the methylation of spherulin4 are associated with the formation of spherules, but these changes are probably transient. Methylation of the gene accompanies its transcriptional activation, and spherulin4 mRNA is only detectable in late spherulating cultures and mature spherules. It is a spherulation-specific protein.	28.50	28.50	28.60	36.00	25.90	28.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.97	0.70	-4.95	44	221	2009-07-15 17:01:16	2009-07-15 18:01:16	3	11	122	0	141	236	0	229.90	25	69.40	CHANGED	tplllPlYl.YP....tssss.Ws.L.................t......................lsshPsltaslllNP.ssGPGtt.....sDssYssslscL....ptss...spllGY..............................VpT....sY..usRsls-Vtp-lspY.......................................ssW.t....................................................................................................................................................................................................................................................................................................................................................................................................thslcGIFlDE..ssssht...sphsYhpplsshl+s.................................htssthVlhNPGs.hP......tssahs...h..u.DhhVsFEssassa...sshsst....t..hlsshs..ts+hst......llaul..................P.............ssspltshsp.phpptu..uhlalT........shsss....Ypshs..shWpp.........hlsslss	...........................................................h..lhlPhYh.aP...........hsss..Ws.L...........................................hss..ssh..hhlllNP.ssGP........Gtt......sDssahpslspL.................phss....scllGY..............................VpTsY............usRshsplhp-lppY.......................................tsW..................................................................................................................................................htlcGlFhDE....sssph...............stl.sahpplsshl+s.................................hts.s..t.hVlhNPGs.hs..........ssahs........h....uDhh.Vs..FEssassa........tts.sst.........t...hhsshs.....p+hstllasl.....................P.............................t.pphttlhp.thtp.ts..uhlahT......................s....sss.....atshs..shapt.ht....t....................................................................................................	0	41	82	114
+11972	PF12139	APS-reductase_C		Adenosine-5'-phosphosulfate reductase beta subunit	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2202 (release 23.0)	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 112 to 142 amino acids in length. This family is found in association with Pfam:PF00037, and has a conserved FPIRTT sequence motif. The whole beta subunit has the enzymic properties of EC:1.8.99.2.	25.00	25.00	25.50	39.80	23.00	18.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.87	0.72	-3.84	43	261	2009-09-11 09:55:26	2009-07-16 09:44:11	3	10	227	18	53	254	806	83.70	48	62.12	CHANGED	lRGYADFsPhGuoshPhRuo-c..IMWTlKFRNG.slKRFKFPIRTTsEG...ohsPhtGhst...ssDL.cophLhoEst...................tthclsssc	.lRGYADFsPhGuolhPhRus-s..IMWTlKFRNG.slKRFKFPIRTTPEG...oh.ssa.s.uhst...sscL.csp.lLasEst...................ht......................	0	25	44	50
+11973	PF12140	DUF3588		Protein of unknown function (DUF3588)	Assefa S, Bateman A	anon	PFAM-B_2205 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with Pfam:PF02820. The exact function of this family is not known.	25.00	25.00	25.40	30.90	24.30	24.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.58	0.71	-4.02	15	369	2009-07-16 09:36:54	2009-07-16 10:36:54	3	15	82	0	178	312	0	113.30	42	17.18	CHANGED	ssssVslYlNK+sssGPaL-+p+ltpLPsaaGPGssslVLppslQuslssAYpsppVhphLp..ps...GGE..slpApa-GKsaplpLPs...VsosshVh+FLcplCppLp....C-NLFSspPho	..........................................ssp.tlYlN+pstsGPaLs+p+ltpLPpphGPupsslVLpps.lpthIssAacsppVhphLp....ps.....sGp....slpAp.acGcpa...p...hslss...VposshVhcFlcplCppLp....CsNLFusp.h....................	0	23	35	88
+11974	PF12141	DUF3589		Protein of unknown function (DUF3589)	Assefa S	anon	PFAM-B_2240 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 541 and 717 amino acids in length. The function of this family is not known,	25.00	25.00	50.60	44.50	17.60	17.10	hmmbuild  -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.94	0.70	-6.27	31	145	2009-07-16 10:10:52	2009-07-16 11:10:52	3	2	27	0	113	176	2	461.20	29	74.19	CHANGED	ppCpp.lphptslplopspshs....ssLcplhspllpp.p....shap-lpshF.tclpcphccphl.cK+Wa+FuGSSVWL-pYGVHaMlSRllYS.pGh+spPhlSLhYsQlFDcNWpElps.hpLllP...................h..sctsac.hp...FPsFLPIPhaashc...ppppaYGPEDPRllLhc.....NphGh-EPllVaNua+cc.ls......................p........ahRoMFhsaPap.p................tp..as+shEL+lcsppctppEKNWTPF..ls..........pt.pshDpalaFlYpassLclL+CsL....ssus......Ccaha+......phsspsplGsLRGGTpLlslsphh...........................thspsRclWlGaARuHlcpCGCGpsMYRPNhllLs+s..................spaclualSShlsFslsl.sWshp.............csh....Cts..tsVLIPNuISpWslpp.........................................t.t..hpDhhTlolShADposcllal+GlLppIhsls................................t...htppppttttsshtlcCAlptSpca	...........................................pCpp.lphptp..lpl.op.t.h...h.p....ssLtplhpplhpp.p...........hhpclpshF....clp.p.............p............pphl.....cK+Wa+FuGSSVWLcpatVHhMlSRllYS.pGt+spPhlSLlauQlFDcsWpElp.s.hpLh.lP................................................................tphphp..hp......aPphLsIPhhhs.p.....tptpahGPEDPRllLhc.....Np.Gh-EPlllFNhhcpp.hp.......................................hRuMFhhhPap.......................................sclhcLplpsp.pht.phEKNWoPFhs................t.tpttcsplaFlYpapsLclLKCsL....ssu.................Cphhac.........t.pppspsGslRGGTpllslsphhs.........................................h.ps+plWlGFsRsHlppC.GCGpphYRPphhllscs......................p.spaplshlSs.lsFslslhsWs.t.................pshCss..tNlLIPNuIu.Wpltp........................................................................p.thpDYhslolStuDtsspllpl+GlLphlhpl...........................................pttpt...pp..hpCsh..u.pa.......................................................	0	17	53	113
+11975	PF12142	PPO1_DWL		Polyphenol oxidase middle domain	Assefa S	anon	PFAM-B_2219 (release 23.0)	Domain	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length, and the family is found in association with Pfam:PF00264. Most members are annotated as being polyphenol oxidases, and many are from plants or plastids. There is a conserved DWL sequence motif which gives the family its name.	20.60	20.60	20.60	21.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.59	0.72	-4.45	39	355	2009-07-16 12:13:27	2009-07-16 13:13:27	3	8	124	8	85	375	0	52.10	52	10.25	CHANGED	DhTDsDWLsupF.lFY.DE..NsphVRV+V+DsLD.sc+LGYsY.pcVs..lPWlsuKPssp	....DhTDsDWL-u.uF..hFY.DE..pucLVRV+VRDsLD.spp..LtYsY.Q-Vs..lPWLss+Pss...............	0	16	67	78
+11976	PF12143	PPO1_KFDV		Protein of unknown function (DUF_B2219)	Assefa S	anon	PFAM-B_2219 (release 23.0)	Domain	This domain family is found in eukaryotes, and is typically between 138 and 152 amino acids in length. and the family is found in association with Pfam:PF00264. Many members are plant or plastid polyphenol oxidases, and there is a highly conserved sequence motif: KFDV, from which the name derives. This is the C-terminal domain of these oxidases.	20.60	20.60	20.60	20.60	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.70	0.71	-4.26	32	337	2012-10-01 19:33:20	2009-07-16 13:34:11	3	12	111	0	86	438	1	119.10	40	22.90	CHANGED	FPl.sL-cs.lp.spVpRP+.poRoc+E.K--EEEVLVI-GIEh-psh.h.lKFDValN.D-scsss..ssspsEFAGSFlslPHt.+pp.......t+p...hpTsh+LGlo-LLEDLsA-sD-.ollVTLVPRsGs..s.l.pIsGlcI-h	......................FPh.sL-ps.lp..ssVpR.Pp.tsR....occE....K--E..EEVLV.I-GIEhccc..h..VKFDValN..s-sstss..sssssEaAGSFsplPHt..ppt..........ttp......hpoph+huls-LL.-Dlss-s...Dc..ollVolVP+hGs..t.l.slsulpIth.................................	0	9	70	79
+11977	PF12144	Med12-PQL		Eukaryotic Mediator 12 catenin-binding domain	Assefa S	anon	PFAM-B_2250 (release 23.0)	Domain	This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.	25.30	25.30	25.90	25.90	19.70	17.40	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.72	0.71	-4.94	4	106	2009-07-16 15:03:35	2009-07-16 16:03:35	3	6	38	0	42	87	0	181.20	53	11.28	CHANGED	PP-LhQsts.G...RlsYtQpuMNMYTQNQPLPPGGPGLEPPYRPsRsP.MNK.MPsRPNYTuhMssMQ.usMsslMGL-K...QYsMsaKPQPsMPQGQhLRpQLQsp..sQuhIGQ.QlRQMTPNpsYouMQsS....QGYToaGSHMGMQQHsSQsGGMsPsSYGsQsFQuTHPAsNPslVDPpRQLQQRPSGYVHQQAP.uYsHshQsTQRFs.HQs	............................hhpp..........phsY....t..t.p.GhasQNQPLPs..GGPRlD...s..aRP.sRhs..hpK.hssRP..sYsuhh.P.............ssM...su.......lhul-s...p..pp..h.hp.ppQPshsQGQp......L.R.pQ......LQs+..............pQ.......GhhG.Q...p.......l....+Q.hsPs...s...p.Y.GLQsu.......Q....GYTsYsSHhuLQQHs..u...uus..hV..sPSYsupsY.usH..oNPsLhDshRplQQR.PSGYVHQQAP...sYsHsLsuoQ.Rhs.HQ....	0	2	5	16
+11978	PF12145	Med12-LCEWAV		Eukaryotic Mediator 12 subunit domain	Assefa S	anon	PFAM-B_2250 (release 23.0)	Domain	This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.	20.30	20.30	20.30	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.94	0.70	-6.01	7	175	2009-07-16 15:05:44	2009-07-16 16:05:44	3	10	89	0	108	157	0	397.50	46	22.82	CHANGED	s-FVQSthLuRRLAYhso++Lu........Lls...............................usppspsIpspsssshsssssspsssppsPhphsFo-ahpCspHRslVhtLSsILQsITLpCPoALVW.............shutscopsph.GSPLD+LPlAPSsLPMPst..ssthNppVRtpLhpsEppIK.RuptsEsRWshDKhQpu......AG.shs+VLpTL-sLDsHsF-RhDpsNSlDoLYs+IFsstpscstcpsp.........................................ppD-ulVplLCEWAVSppR.GcHRAMVVApLL-KRQs-l.sphss-S.....ps.D-K-SlsSGuhsssuhPVFQcVLhpFLDspAPsLs-..soppp+spFsNLVhLFsELIRHDVFSHsAYMCTLISRGDLhs...................Tushop.sususpsssstthc-pshtss.chc..ths-S...D..sp.................hhpchpEctpsS.-tssssp..cstpp-.shphshstshs.sRHh.YspHFPlsQ--s..upH..-CNQRhllL	..........................................................t.EFVQSthLSRRLAYhCsR+Lu.......h.Ls...............................................................................................................sspssch.h.s.........s.ss..shsssss.....stssss.sP.phsFsD.hh....CspH.+.s.lVauLSChLQslhLsCPSALVW...................pYuhscs+............ts.GSPLDhLP.lAPSsLPMPtG..sosh...sQQVRs+lhElEpQIKpRGpAVEsRWS...FDKCQEuT........A.GhTIuRVL+.T.LEVLDpHsF-..R..sD....oNS..l-oLhp+IFh.s.s.K.....DspEhs.........................................ssD.-AV.VsLLCEWAVSsKRsGcHRAMsVAKLLE.KRQuElEAE+.sG.-.S..................EshDEKtSl.uSuSluusoh.PlFQsVLlpFLDT...QAP.Lo-...spo.-..p...E+sEFhNLVLLFsELIRHDVFSHshYhCTLISRGDLuh.....................................................sus.spP.oP....sc..ss--...............K....-.t.cht.........t...t...t..........hs..p....h....h-..sp..............................................h..scs....pspsS.pp..s..pp...c.s..c-p........h.p.hh....s....hs.sRH..lpYsoH.FPI...P...--s.....sSH...ECNQRhllL........................................................................................................	0	35	41	73
+11979	PF12146	Hydrolase_4		Putative lysophospholipase	Assefa S	anon	PFAM-B_2243 (release 23.0)	Family	This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. Many members are annotated as being lysophospholipases, and others as alpha-beta hydrolase fold-containing proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.62	0.72	-4.13	137	1506	2012-10-03 11:45:05	2009-07-16 16:11:07	3	13	1223	0	398	8635	1896	80.60	30	22.07	CHANGED	GhpLh.hpp.Whs...s..ss......+uslll.h.H.Gh.s.EHus..+..Ypc.luppLst.pGaslauhDpRGHG.pS.....s......G.....p..Ru...h..hssas..ph..l.c..D.lpph...lp	.........................................htLahpp.W.s...........ps........s+u.l.lhl.h.H...G.....h....t.....E..H..uu.....R..........Y...p......c.....l....s..c....pL...s..p.....s..G......a..s..V..a..u..aDtRG...HG.+S......s........................G...........+G......h......h..s..s.h.s......ph....V.p.Dltphh.t........................................	0	130	239	317
+11980	PF12147	Methyltransf_20	Hydrolase_5;	Putative methyltransferase	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2243 (release 23.0)	Family	This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. The family shows homology to methyltransferases.	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.83	0.70	-5.55	16	478	2012-10-10 17:06:42	2009-07-16 16:16:36	3	6	461	0	55	393	49	296.00	64	53.99	CHANGED	s+hRcFI.ppFspssppsuLhcAD+tGsop-Eu-tLuuPhst.S.psLaWphsRtul+hGGhhScGl+LGhcTGFDSGSTLDYVYRNpspGpG...slG+hID+sYL-AIGWRGIRpRKhHlpELlptAltRL+upGpPVRllDIAAGHGRYVL-ALsststt.....s-uIlLRDYSslNVppGpsLItp+GLssIA+FEpGDAFDtsoLAulpPtPoLAlVSGLYELFsDN-hVtpSLuGLApAlpPGGYLlYTGQPWHPQLEhIARALTSHRsGpAWVMRRRSQAEMDpLVctAGFcKlsQRIDpaGIFTVSlApR	...............................................-KMpsFIsRLYAsps......p+FDYpHEDRsGPSADcaRhLuusPsPhSPhDLsYRhhRtuMKL.hGsaSsGl+LGhsTGFDSGSSLDYVYpNQPQGSs....uFGRLIDKhYLN.SlGWR.GIRQRKs.HLQhLI+Q.AVAcL..+u..cG...hsVRVVDIAAGHGRY...VLDALsscPu.......ls.-I..LLRDYSELNVsQGQtMIAQRGhSups.RFEQGD....A....Fs...sE....-L.uAL......o.P.RPT.L..A.IVSG.LYELFP-.N-.t.V.KNSLAGLAsAIEPG.GlL.IYT..GQPWHPQLEhIAtVLTSHK.D.GKP.WVMRVRSQuEMDoLVccAGF-..KCTQRI..DEWGI..FTVShAVR..............................................................	1	7	25	38
+11981	PF12148	DUF3590		Protein of unknown function (DUF3590)	Mistry J, Gavin OL	anon	pdb_3db3	Domain	This domain is found in eukaryotes, and is typically between 83 and 97 amino acids in length. It is found in association with Pfam:PF00097, Pfam:PF02182, Pfam:PF00628, Pfam:PF00240. There are two conserved sequence motifs: RAR and NYN. The domain is part of the protein NIRF which has zinc finger and ubiquitinating domains. The function of this domain is likely to be mainly structural, however this has not been confirmed.	20.90	20.90	21.60	20.90	20.20	17.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.05	0.72	-4.37	8	130	2009-09-11 05:19:17	2009-07-16 16:52:31	3	11	53	7	70	130	0	88.80	47	12.11	CHANGED	hlDARDsshGAWFEAplVsVo+cssscs............-sllYHVKYDDYPEsGVlplssKslRPRARTlLpWc-LcVGpVVMVNYNsDpPKERG	...............................VDs+DpphGAWFEAplspls..pcs.sst-........................................EDlIYHlKYDDYP.EsGl.lphss+..DlRsRARTll+Wp-LpVGpVVMlNYNs-sPcERG.......	0	14	18	36
+11982	PF12149	HSV_VP16_C		Herpes simplex virus virion protein 16 C terminal	Mistry J, Gavin OL	anon	pdb_2k2u	Domain	This domain is found in viruses, and is about 30 amino acids in length. It is found in association with Pfam:PF02232. This domain is the C terminal of the HSV virion protein 16. This protein is a transcription promoter. The C terminal domain is the carboxyl subdomain of the acidic transcriptional activation domain. The protein binds to DNA binding proteins to carry out its function. Such proteins include TATA binding protein, CBP, TBP-binding protein, etc.	20.10	20.10	20.60	61.80	17.70	18.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.05	0.72	-7.38	0.72	-4.27	2	19	2009-07-16 15:54:40	2009-07-16 16:54:40	3	1	10	3	0	46	0	30.10	85	6.14	CHANGED	DsssYuuLDhADFEFEQMFTDALGID-FGG	.DuAPYGALDMADFEFEQMFTDALGIDEaGG	0	0	0	0
+11983	PF12150	MFP2b		Cytosolic motility protein	Mistry J, Gavin OL	anon	pdb_2bjq	Domain	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are found in nematodes. They complex with MSP (major sperm protein) to allow motility. Their action is quite similar to the action of bacterial actin molecules.	18.80	18.80	22.30	21.50	18.50	16.00	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.36	0.70	-5.75	3	68	2009-07-16 15:56:21	2009-07-16 16:56:21	3	4	10	3	60	63	0	286.80	43	80.89	CHANGED	NPPAKEDTWAFQPIGSPFP-uPVKshGQQNMYVALWYKHGKPIHGRAWNNGGVVECSFPYNKAELTGKpDLGGQIQVLQYKGDHNSLGYWYEWIKYKDRaEKhDct+ElVRCGDSFPILWpcRsGGsLLGYVDNKTElAhFSasGKV-KhpGuALANMhIIsRNLhGGPPaC.Ct.CtusPPsP..llRVpcDEWhDlRpGDPWPTptssV+ALGRoLDTLPGsNPDQYVALWYppGEPVMGRlW.N-GGKlAAsFGWsNpEYs.pcVGSIQLLhhLP-SlRGFDYcWhPFPEAAQFGsKtWpPVHVspHKGNISPuVLplscGKEILGKlDlRNEKAohGYGGKEKlhTGsA.VcsshVLCRKAKA	................................EDpWAatsIGuPFPssPV+s.sppNhYVALWYKHGK.PIHGRu.W..NN.sGVVE.CSFsYpcs..ELosttpLtGQIQlLpY...h.....Gsaps.GFWY-WlpaKc..R.hp.p..-tttph.l.RCGsShPl.hh.p+.ttslLGalD.pTE.AhFu..sGps.p..Gst.hsshhllsRNhhst.st.s.p..t.t......sPPs.s.................+lh..hD-WhDhR.GDsaPstt....V.Ahs+sLsT.sGsp..QYVALWYh.pG.c.P.VhGRsW.sps.GKltAsFuh.spEas.tplGSlQlLhplsspshGa-YsWhsa...............s-uspast..K.ahP.VHl....G.hussll.....tG+plLuplDh+pEphs.huatGKEp.h.Gss.stshhVLCR+th.................................	0	22	28	60
+11984	PF12151	MVL		Mannan-binding protein	Mistry J, Gavin OL	anon	pdb_1zhq	Domain	This domain family is found in bacteria, and is approximately 40 amino acids in length, There is a single completely conserved residue G that may be functionally important. The domain occurs in two types of proteins. In mannan binding proteins [1], it forms a homodimeric molecule which complexes into a homo-octamer. In thiamidases it occurs without repeats but in the presence of other domains. MVL is distinct amongst other oligomannoside binding proteins in that it exhibits specificity for certain tetrasaccharides. Each molecule of MVL has four distinct carbohydrate binding sites.	25.00	25.00	28.20	27.20	21.50	19.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.29	0.72	-7.89	0.72	-4.29	16	75	2009-07-16 15:56:42	2009-07-16 16:56:42	3	5	57	32	26	83	0	38.30	38	13.12	CHANGED	sspApussPshCushGup..WsGQWssTsssuh.....oVsshp	.......tApAssPohCushGGp..WsGQassssssu.t...puspshp....	0	5	13	21
+11985	PF12152	eIF_4G1		Eukaryotic translation initiation factor 4G1	Mistry J, Gavin OL	anon	pdb_1rf8	Domain	This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with Pfam:PF02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.	18.80	18.80	19.40	19.70	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.59	0.72	-4.08	20	155	2009-07-16 15:57:30	2009-07-16 16:57:30	3	6	127	1	110	160	0	75.70	36	6.16	CHANGED	stpstsspsss.p.ohSphLppLcpApsI...-DlhshpYPpslpuPDschppss....hKYcYsPsFLLQF+cllphpsDsp	...................t..t..sspssp.sspsSthhpsLpoA+hl...-.DltphsYPt..uIpuPsstlNtss....tKa+YstpFLLQFpsVhp-+Ps..h....	3	33	64	96
+11986	PF12153	CAP18_C		LPS binding domain of CAP18 (C terminal)	Mistry J, Gavin OL	anon	pdb_1lyp	Domain	This domain family is found in eukaryotes, and is approximately 30 amino acids in length, and the family is found in association with Pfam:PF00666. CAP18 is a protein which is derived from rabbit granulocytes. It has two domains, an N terminal DUF and a C terminal Gram negative LPS binding domain. This domain is the C terminal domain.	20.50	20.50	20.70	22.80	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.10	0.72	-4.30	11	48	2009-07-16 15:57:40	2009-07-16 16:57:40	3	1	33	6	9	49	0	28.10	49	16.48	CHANGED	uchLpKutEKIuctlK+IGQKIKDF..Ftp	.GshhRKupEKIGcclK+IGQ+IKDF..htp..	0	1	1	1
+11987	PF12154	HCMVantigenic_N		Glycoprotein B N-terminal antigenic domain of HCMV	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2260 (release 23.0)	Family	This domain is found in viruses, and is approximately 40 amino acids in length. The domain is found in association with Pfam:PF00606. There are two conserved sequence motifs: SVS and TSS. This family is the amino-terminal antigenic domain of glycoprotein B of human cytomegalovirus.	25.00	25.00	25.40	35.10	17.70	16.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.85	0.72	-4.05	3	111	2009-11-24 12:46:55	2009-07-17 10:42:19	3	2	5	1	0	89	0	36.30	76	11.90	CHANGED	HHSSHTosAA+SQSGSVS.QHVTSSQTVSHcsNETIY	.HpuSHTopsspuQotSVSSQ+VTSSEAVSHRANETIY.	0	0	0	0
+11988	PF12155	NADHdh-2_N		NADH dehydrogenase subunit 2 N-terminal	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2270 (release 23.0)	Family	This domain is found in eukaryotes, and is approximately 90 amino acids in length. It is found associated with Pfam:PF00361. All members are annotated as being NADH dehydrogenase subunit 2, and this region is the N-terminus.	25.00	25.00	26.10	26.10	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.08	0.72	-3.81	2	221	2009-07-17 10:13:53	2009-07-17 11:13:53	3	1	205	0	0	181	0	85.30	93	47.06	CHANGED	MELTLGLIILIVLhYGLKAPTLRLAhlhhGhl....LLhtspLLshTQAIKMLVhLSGLAlLCMLDHphSaRSSSLLILLVILGNLLL	MELTLGLIILIVLTYGLKAPTLRLAMLLAGA......V.....G.AAGLL.AEPHLLCWTQAIKMLVMLSGLAILCMLDHRTSHRSSSLLILLVILGNLLL	0	0	0	0
+11989	PF12156	ATPase-cat_bd		Putative metal-binding domain of cation transport ATPase	Assefa S	anon	PFAM-B_2287 (release 23.0)	Family	This domain is found in bacteria, and is approximately 90 amino acids in length. It is found associated with Pfam:PF00403, Pfam:PF00122, Pfam:PF00702. The cysteine-rich nature and composition suggest this might be a cation-binding domain; most members are annotated as being cation transport ATPases.	27.00	27.00	27.30	27.00	26.80	26.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.55	0.72	-3.45	88	725	2012-10-03 05:12:49	2009-07-17 13:04:01	3	7	717	0	192	664	62	83.30	30	10.60	CHANGED	tsCaHCGtsl.s..tstphpsplpGpp..........+thCCsGCpuVspsIhcsGLssYYchRspsutpspt......tp.hp...phphaDps..-lpppFVppp..ssts	.......pCaHCs.sh......tp..t.hphchtGpt..........+.hCCsGCpuVhphlh-u.GLssYYctcsssuhp..stt....h.pp..hp....phthhD....pl.tpalp.t.t..tt.........................	0	60	126	165
+11990	PF12157	DUF3591		Protein of unknown function (DUF3591)	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2298 (release 23.0)	Family	This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.	25.00	25.00	37.20	25.90	16.40	24.30	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.52	0.70	-6.09	20	386	2009-07-17 12:30:32	2009-07-17 13:30:32	3	36	271	0	294	397	1	387.00	32	30.51	CHANGED	FNI...SNDctY-hLKcsapsKVRuTluslslEHShPAh+LQhPaYKlcLs+p-hRuFHRPshshp.......Pssphs..Fs+lKhpK+K+c+......uKslpElFp..sopDLohsD.susllLhEYSEEhPhhLSNFGMuoKlINYYR+pstcDssRPKhc..lGETplLtspD+SPFh.FGpV-PGchVPTLaNNMhRAPlFKHcscsTDFLllRSos...sssuscaYLRsIsplFsVGQpaPs.sEVPGPHSR+VTshsKNRL+MllYRllp....+stp++.....lplcsls+HF.PDps-hQNRQ+LK....EFhcY.pRcu..t..pGaWclKps-slPsE.cslRsh.....loPE-lChl-SMpsGtppL.cDuGYspssch............tc-tct............thslEppLAPWssT+NFlsAopGKAMLplHGtGDPTGpGEGFSFl+T.SMKGGFh.psscsspspstpshstpch.p.puuH.YNVupQQ+hY...--EIc+lWptQppSL	....................................................................aNl...SNDphY..h..pp........t...l....+...s...shu.s....lpHShPAlcLp.Paa.s.chs..chRpFHRP.hphh....................st.t.h......h.thhc+.Kt.p.........................................upsstphFh....pspD.LohpD..usllLhEYsEEtP.lhsphGMus+lhNY.........Y...........+...............+c.s.s..cD.............s........s.....h..s.chc...............h..GEs.hh..ht..........s...SPF..hG...p...lcPGph..l.......slpNshaR.A...........Pla................H................c...............p.....TD..FLllRopp......................................taa...lRpls.....pla.slGQph......P...hEVPuP.pS++ssshh+shL..ph.hhYRlhh...........ps..p.pc..............lphp-lpct..F...Ps..p...s..-.p.Rp+LK................hhpa.....p+..s.s......t..........pshWhl+.s..s....plPsE.-plRsh...lsPEp..........sChh.SM.suppcL.cDsGasppt..h............................................pp...ttpp......................................ths.E.phAPWssT+sFlt.....Ah...p...u..........K....s...h...LplpG.uDPT.G.p..G..pG..FSal+h.s.Kss........t...t..tp.....p......................t.............t........l...ss..pchc.tthp..sstp..pha...--pIp+l.phph.s......................................................................................	0	118	175	242
+11991	PF12158	DUF3592		Protein of unknown function (DUF3592)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2016 (release 23.0)	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in  bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.	29.00	29.00	29.00	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-11.43	0.71	-4.41	88	745	2009-07-17 13:18:40	2009-07-17 14:18:40	3	7	584	0	211	607	46	147.30	21	83.87	CHANGED	hhhhhhh......shhhhshuhhhhhhshhhh.......................................hth.psh................................................................................hpspGplhshp.....................t.tptppsstapsh.lpaphs......sG..........p.......php....atps.......ssp.st...........ht.....hGp.pVsVh.........YsPssPpp..................uhlp..............................................................................................h...........thashshlhhh.........................................................................................................................................................................................................................................................................Gh........hhh.....hsGlhhhht	.....................................................hh.......hhhhh..sl.G...lh..l.llhu.shhhhtp.........................................hphscss................................................................................hcspG.hl.l.css................pp.pp.ps.s.....p.ss.sah..P....s..ltapss......ss.............p.....plt...........asss...........hsushhp.........................................s......tGc.pVs.VaYsPscPpp..................Ahls.....................................................................................................................psh....h.............htashhslhhh..............................................................................................................................................................................................................................................................................................................Gh..........lhh...hhGh.....hh..............................................................................................................................................................................................................................................................................................................	0	73	134	179
+11992	PF12159	DUF3593		Protein of unknown function (DUF3593)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2028 (release 23.0)	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in  bacteria and eukaryotes. Proteins in this family are typically between 98 and 228 amino acids in length. There is a conserved LHG sequence motif.	25.00	25.00	43.70	43.70	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.10	0.72	-4.20	34	137	2009-07-17 13:37:51	2009-07-17 14:37:51	3	4	116	0	75	140	115	91.60	48	58.03	CHANGED	hs.ssLFuLSLlPYLsFLaaL....p+spp.hPpLslhGFthTLlFVulTIssulhApphaG.spLusVDhLHGuAEuFLTLSNhllllGh..hpthpptp	......h..ssLFAlSLhPYLuFLaaL.....s+opp..hPpLslhGFahlLlFVusTIsAuIhAphtYG.psLusVDaLHGuAEuhLTLoNlllVLGhppultp.h.....................	0	24	48	68
+11993	PF12160	Fibrinogen_aC		Fibrinogen alpha C domain	Mistry J, Gavin OL	anon	pdb_2jor	Domain	This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with Pfam:PF08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.	20.50	20.50	22.10	20.90	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.46	0.72	-4.51	12	67	2009-07-17 15:11:56	2009-07-17 16:11:56	3	4	38	2	24	74	0	68.70	47	10.34	CHANGED	usEKV..TSu...uToTT++SCSKTlTKTVl.GPDG++EslKEVlsS-DGSDCu..cs.cls.....hsHsF...pGuLD-hp	...........upEKVTSu...uToTTR+SCSKTlTKTVl.GPDG++EVsKEVlsS-DGSDCs..-sh....-Ls.........hhcsF...tGshDth......................	0	1	2	8
+11994	PF12161	HsdM_N		HsdM N-terminal domain	Bateman A, Assefa S, Coggill P	anon	PFAM-B_2036 (release 23.0)	Domain	This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with Pfam:PF02384. Mutations in this region of EcoKI methyltransferase Swiss:P08957 abolish the normally strong preference of this system for methylating hemimethylated substrate [1].  The structure of this domain has been shown to be all alpha-helical.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.20	0.71	-3.74	142	4604	2009-07-17 15:36:28	2009-07-17 16:36:28	3	25	2890	12	944	3684	555	134.60	20	25.85	CHANGED	lpstlWshA.-hLRss..h...ssscY...tchlLsllFl+hls-hhptp....ppph................................................hh...t............hh.......ss............phpa...sp............lh.p.....................ss......ltptlpp.............hhptlppp........................lpslh..p...ph.t.t...........psphLtpllpth	...............................................ppplWphs.-hLRus.....h.sssca...pphllsllFlKhls-phppt...........hpch..................................................................................................ht.th.t.........................ah..l......st...................phpa.......ps.....................htpp......................................ttps......lhphlsp................hhptlcpt....s.............................s.........hculh..c...ph.p.....t.t..........tps..phLtpllph.............................................................................................................................................	0	338	667	826
+11995	PF12162	STAT1_TAZ2bind		STAT1 TAZ2 binding domain	Mistry J, Gavin OL	anon	pdb_2ka6	Domain	This domain family is found in eukaryotes, and is approximately 20 amino acids in length, and the family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. This domain is the C terminal domain of STAT1. This domain binds selectively to the TAZ2 domain of CRB (CREB-binding protein). In this process it becomes a transcriptional activator and can initiate transcription of certain genes.	21.60	21.60	24.80	28.00	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.35	0.72	-6.82	0.72	-4.48	8	87	2009-07-17 15:38:57	2009-07-17 16:38:57	3	8	48	1	30	65	0	24.20	65	3.35	CHANGED	SRLQ..-NhhPMSPD-acELcRhVu	..SRLQoTDNLLPMSPEEFDElSRhVG........	0	5	7	12
+11996	PF12163	HobA		DNA replication regulator	Mistry J, Gavin OL	anon	pdb_2uvp	Domain	This family of proteins is found exclusively in epsilon-proteobacteria. Proteins in this family are approximately 180 amino acids in length. The structure of HobA is a modified Rossmann fold consisting of a five-stranded parallel beta-sheet (beta1-5) flanked on one side by alpha-2, alpha-3 and alpha-6 helices and alpha-4 and alpha-5 on the other. The alpha-1 helix is extended away from and has minimal interaction with the globular part of the protein. Four monomers interact to form a tetrameric molecule. Four calcium atoms bind to the tetramer and these binding sites may have functional relevance. The function of HobA is to regulate DNA replication and its does this by binding to DNA-A, but the exact mechanism of how this regulation occurs is purely speculative	20.20	20.20	20.80	79.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.12	0.71	-4.99	15	195	2009-07-17 15:52:56	2009-07-17 16:52:56	3	1	194	6	22	95	3	176.60	56	99.59	CHANGED	Mp-FlpWoLEsIRc-..puhhu....WhEE+RhEWsPLlAspLcaLL-.GtohIVlTD-cRcWFpsYhlspINpsp.psRP.hLPhhsL+ulas.hcslpss..EsIsLlpDMLsIuFsNsYhaaYIGK.usct+upIAKs+-sSahWlFDEphQNSFhLsSpD-tLDhKLLpLa+LF-cSLsAsLFu+VsL	..................MsDFLoaTLEsIRss..Gs.FMA.....WLEpRRlEWAPLhAuRL+aLLE.G+TFlLhsDEpRuWaEEYhLpNIN.o+.ssRP.hLPFVS.LsSLhc..++.lpsp...E..DIALLsDhL-ISFPNGalaFYIGp.uoDs+ShIAKS+DDShLWLFDEQ.LQDSFYLsS+Dc.cLDlKLIoLY+LFDsSLDAlLFuKVpL....	1	5	18	22
+11997	PF12164	SporV_AA	SporV_proteinAA;	Stage V sporulation protein AA	Mistry J, Gavin OL	anon	pdb_3g74	Domain	This domain family is found in bacteria - primarily Firmicutes, and is approximately 90 amino acids in length. There is a single completely conserved residue G that may be functionally important. Most annotation associated with this domain suggests that it is involved in the fifth stage of sporulation, however there is little publication to back this up.	25.00	25.00	28.10	27.70	24.10	23.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.96	0.72	-4.00	17	224	2009-07-17 15:54:56	2009-07-17 16:54:56	3	1	222	8	32	178	4	92.40	35	44.56	CHANGED	MppplYl+h++clpls.ppplpLtDlApltusp.slhp+Lpshslh+l...opcc+phhVlslhclIptI+pp.hPsl-lQslGtspsIVElphpK+ps	......ppslYl+hRpRlcVp.shcVpLGDlAQltuss.slhcpLpsh....hlY+l................sscD+s..+lVI.DlhKlIchIp....pp.hsplplp..hlGsupTlVElhhcK+ps.................	0	9	22	24
+11998	PF12165	DUF3594		Domain of unknown function (DUF3594)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2040 (release 23.0)	Family	This presumed domain is functionally uncharacterised.This domain family is found in  eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00628.	21.00	21.00	22.10	21.20	20.60	20.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.94	0.71	-4.54	8	251	2009-07-17 16:40:26	2009-07-17 17:40:26	3	8	37	0	129	263	0	126.50	65	52.68	CHANGED	RTVE-lF+DFKuRRuGIl+ALTsDVE-FYpQCDPEKENLCLYGaPNEsWEVNLPAEEVPPELPEPALGINFARDGMpEKDWLSLVAVHSDuWLLSVAFYFGARFuFs+sDRKRLFsMINDLPTVFEVVTG.AcKQsK	.........................RTVE-lF+DF+uRRuGll+ALTsDVEcFYp...CDP.E.K.ENLCLYGhPsE.sWEVsLPAEEV.PPELPEPA.LGINFARDGMpcKDWLSLVAVHSDuWLLuVAFYFGAR........hs+s-R.....KRLFsMIN-LPTlFEVVTGt.pt..........................	0	20	83	110
+11999	PF12166	DUF3595		Protein of unknown function (DUF3595)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2166 (release 23.0)	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in  eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.	26.90	26.90	27.10	28.80	24.60	26.80	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.30	0.70	-5.66	24	389	2009-07-17 16:45:50	2009-07-17 17:45:50	3	9	130	0	250	313	3	308.60	33	22.84	CHANGED	ptlPFLaELRslhDWshocToLslhpWhplEDIaspla.hpsthps.cph.t.pGpphshhsKhhhGshhlhhllhllahPLhlaSshsss.spsN.lhssshplslssh........shaph........ssphphhsssthtpl.....tt.htppptthp........hhtshstpslptsplsspSsshWslSssuhppllppLpssst.....slphphsap...hpRshsttsshtths..p...............hths.stptsLtphLps..............................sstsl.lsphaspalps.s...sstsp.hpt..............ttpshhshshthhpsptst...............sstaWsls.tpss...t....................t.sttsppsslhhhlhs-cssss.h..uhlsuh..GIlulYsohlLslG+hlR.uhhsstspplhhpchsps-cllplCpsIhlsR......p...ss-htLEptLahcLlplhRSPEpllchTtst	............................................hhlPFLhELRslhDWshos.Tolsl.pWhphEDlaspla...hc..s..ht...pp.......t............h...u.........h.K.hh.Gh.hhhhllhhlhhPlhhhu.hpss..s..N.shpss..hplpltsh.................shath.............t.pl...hp.p.hpph.................h........shp...................altt....a..t.p.-l.h........hphpspSsthWtlssssptphhppL.pst.................th.hhhpap...hpRph...s...tt...h..ht..........................h....t........ttt.lhp.hltt.....................................................ttshhl.phhP.alps.s...tspsp.hp.........................t.thh.shph.....h.tt.........................................taW.hp............................................tttt.l..hhhhs-cs.ss.h....shlssh...GIhuLYhoh..VLslu+.hlR.thhst.shpIha--LPssDcllplCp-IalsR......p...tt-htlEctLahcLlhlaRSPchhlchTp................................................	0	95	131	192
+12000	PF12167	DUF3596		Domain of unknown function (DUF3596)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2234 (release 23.0)	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00589. It is likely that this domain acts to bind DNA.	21.90	21.90	22.40	22.50	21.20	21.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.93	0.72	-4.44	60	686	2012-10-03 08:51:45	2009-07-17 17:52:51	3	6	484	0	96	500	13	62.00	47	16.03	CHANGED	hsulcsR.....ssp.....LplsFpYpGhRsREph....s..L.sTstNhKpApplhspIptcIphGsFs...YucaF....PpSp	...............PsGVEs+.....Gup.....LRIhF...hY+G.....tRsREsL......G..lsD..Tsc......N......RKhA.G.c.LR.splsatIc.....tGsF-...YucpFPsS..............	0	16	51	80
+12001	PF12168	DNA_pol3_tau_4		DNA polymerase III subunits tau domain IV DnaB-binding	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2296 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.	25.00	25.00	29.50	28.00	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.21	0.72	-3.58	16	635	2009-07-20 12:56:15	2009-07-20 13:56:15	3	5	631	0	50	312	0	82.10	63	13.02	CHANGED	Rsthp+p.........ptsossKKucsAuup+ht...sSsLERlApl....oppspsp..uspssE.ppstccEsYRW+sopss-.ppspsl.sTPpsLK	.........RpQLQRs............QGuTKsKKSEPAAAoRARP..............VNNuALERLASV..............T-RVQARP.....sPSALE..cAPsKKEAYRWKATTPVh....QpKEVV.ATPKALK..........	0	2	12	31
+12002	PF12169	DNA_pol3_gamma3		DNA polymerase III subunits gamma and tau domain III	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2296 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.51	0.71	-4.44	52	3954	2009-07-20 12:56:32	2009-07-20 13:56:32	3	19	3800	30	939	3190	2267	136.90	21	21.86	CHANGED	losspV+sMLGLuD+uplhcLh-slhcGDsssuLsthcstYstGADPhslLpsLh-hhHhlohhchss.s.sps.t...hspsEpp+htshAppLuhtsLsRhWQhLLKGhpElppAscPhtAAEMsLlRLsasusLPsPc-hl+pl	..........................phptlpphLGslspshlhpllcAl.hp......s-s..t...pshshlpplh.spG.h-hpphlp-L.......lph.l.+clhl..hph.......s....P....s.ht..................t..s.ttp.p...h.p.ph........A...pp...l...s...s.ppltthh.p.h...l..h...pu.p.p...-lp.h........u..s.s......+hhlEhsllRhht...........................................................................................	1	304	617	796
+12003	PF12170	DNA_pol3_tau_5		DNA polymerase III tau subunit V interacting with alpha	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2296 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau. The extreme C-terminal region of this domain 5 is the part which interacts with the alpha subunit of the DNA polymerase III holoenzyme.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.67	0.71	-4.25	5	839	2009-07-20 13:12:31	2009-07-20 14:12:31	3	7	835	1	114	517	50	140.40	57	22.10	CHANGED	KALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVALNAWKEESDNAVCLHLRSSQRHLNNRGAQQKLAEALSsLKGSTVELTIVEDDNPAVRTPLEWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESI	.......................................................+ALEHEKTPELuAKLAsE.Al...ER...D.s.WAApVupLuLP..KLVEQlAL.N.A.a.K.Ec..s.s.s.s..l.s.LH..LRSoQRHL.N.spuA.QQcLucALSpL..pGssVE..LTI.lED.DNP.As.+TP.LEW.RQAIYEEKLAQ.ARc.SIIADsNIQTLRRFFDAELDEESI......	1	17	44	81
+12004	PF12171	zf-C2H2_jaz		Zinc-finger double-stranded RNA-binding	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2302 (release 23.0)	Family	This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.24	0.72	-3.71	140	2095	2012-10-03 11:22:52	2009-07-21 10:15:49	3	234	343	2	1311	3181	32	26.70	31	6.11	CHANGED	paaChhCs.+hFpsppsh..psHhpo..KpHK	.....aaCthCs..+tFpsppph..psHhpo.....+pHp......	0	368	611	979
+12005	PF12172	DUF35_N		Rubredoxin-like zinc ribbon domain (DUF35_N)	Bashton M, Bateman A, Krishna SS	anon	Pfam-B_1390 (release 4.2)	Domain	This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins.  The domain is duplicated in Swiss:O53566.  The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain represented in this family and a C-terminal OB fold domain. Zinc is chelated by the four conserved cysteines in the alignment.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.06	0.72	-3.94	158	1253	2009-07-21 15:56:27	2009-07-21 16:56:27	3	17	452	2	560	1184	271	36.80	28	19.70	CHANGED	hpustcscLhhp+CssCGph....h.aPPc.shC..spC.t.ut...shp	............tthtpscLhhp+C..ssCGph....haPP+.shC......PpC.t.ut.p..............	0	123	340	478
+12006	PF12173	BacteriocIIc_cy		Bacteriocin class IIc cyclic gassericin A-like	Coggill P	anon	PfamB_170026 (release 23.0), manual	Family	This class of bacteriocins was previously described as class V. The members include gassericin A, acidocin B and butyrovibriocin AR10, all of which are hydrophobic cyclical structures [1]. The N- and C-termini are covalently linked, and the circular molecule is resistant to several proteases and peptidases [2]. The immunity protein that protects Lactobacillus gasseri from the toxic effects of its bacteriocin, gassericin A, has been identified. It is found to be a small positively-charged hydrophobic peptide of 53 amino acids containing a putative transmembrane segment [3] - a structure unlike that of the more common immunity proteins as found in Pfam:PF08951.	20.40	20.40	91.60	91.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.07	0.72	-3.95	3	5	2009-07-23 10:40:23	2009-07-23 11:40:23	3	1	5	0	0	6	1	89.00	48	98.02	CHANGED	MVTKYGRNLGLsKVELFAIWAVLVVALLLsTANIYWIADQFGIHLATGTARKLLDAVASGASLGTAFAAILGVTLPAWALAAAGALGATAA	............hs.....huhNhsLsKIEpFsIaAlLV.VALLlssuNIYWIADKFGIHLAPGWYQDlVDaVSAGGSLuTAFAlIlGVTLPAWIlsAAuAFGAsSA	0	0	0	0
+12007	PF12174	RST		RCD1-SRO-TAF4 (RST) plant domain	Overmyer K, Coggill P	anon	Pfam-B_8550 (release 23.0)	Domain	This domain is found in plant RCD1, SRO and TAF4 proteins, hence its name of RST. It is required for interaction with multiple plant transcription factors. Radical-Induced Cell Death1 (RCD1) is an important regulator of stress and hormonal and developmental responses in Arabidopsis thaliana, as is its closest homologue, SRO1 - Similar To RCD-One1. TBP-Associated Factor 4 (TAF4) and TAF4-b are components of the transcription initiation factor complex TFIID.	21.20	21.20	21.20	25.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.01	0.72	-4.18	16	135	2009-11-10 14:39:24	2009-07-24 10:38:49	3	7	24	0	80	130	0	69.30	31	11.44	CHANGED	scsPp...SPahPFshLhsslspplspsch.llpppYpch+cp+IoRp-hl+plRpIVG.DpLLtpslpplppp	.................t..hPp...oPhhs..FshLhshlppplspsc...hphlpphYpch+.....cp+IoRcchl+plRtIVG.DclLhpslpplp.......	0	10	44	65
+12008	PF12175	WSS_VP		White spot syndrome virus structural envelope protein VP	Mistry J, Gavin OL	lg7	pdb_2edm	Domain	This family of proteins is found in viruses. Proteins in this family are approximately 210 amino acids in length. There is a conserved NNT sequence motif.  These proteins are structural envelope proteins in viruses. This is the beta barrel C terminal domain. There is a protruding N terminal domain which completes the proteins. Three of four envelope proteins in white spot syndrome virus share sequence homology with each other and are present in this family - VP24, VP26 and VP28. VP19 is the other major envelope protein but shares no sequence homology with the other proteins. These proteins are essential for entry into cells of the crustacean host.	20.40	20.40	23.30	143.10	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.30	0.70	-5.24	3	37	2009-07-27 13:17:05	2009-07-27 14:17:05	3	1	2	13	0	26	0	186.50	49	100.00	CHANGED	M-hu.hhuVsuAILAILol.IlVlIVIhVhpIslNK+l-p+s+slhsNhDEhlRlPIsucA+usaF+hs-sSasTcsLGKVtl+.NGpSDu-MK-ccADLVIToVpG..sRTLsVssGpspohEhThKlaNNTuRDIsIsulolsPsl.......NssS+sFsuSKslpSFoPsllccDcluTFVsGATF-AsIssTssupLlsMhhcss.s..clccK	.Mch....uVsuAILAhhsl.IhVhIsIhhhp.slsKpl-p+scsl.sNhDE.lRlPlsucstusaF+hs-sSasocsLGKltl+.NGpSDupMK-ccADLVITsVpG...RsLpVssGpshohEhThKVaNNTuRcIsIsuhphsPpl........ssS+sFsuSpsspSFoPsslccDcluTFVsGsTFsAsIssTssup.h..hhp......thtp..................	0	0	0	0
+12009	PF12176	MtaB		Methanol-cobalamin methyltransferase B subunit	Mistry J, Gavin OL	lg7	pdb_2i2x	Domain	This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 460 amino acids in length. MtaB folds as a TIM barrel and contains a novel zinc-binding motif. Zinc(II) lies at the bottom of a funnel formed at the C-terminal beta-barrel end and ligates to two cysteinyl sulfurs (Cys-220 and Cys-269) and one carboxylate oxygen (Glu-164). The function of this protein is to catalyse the cleavage of the C O bond in methanol by an SN2 mechanism. It complexes with MtaA and MtaC to perform this function.	25.00	25.00	184.40	28.20	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	461	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.49	0.70	-6.07	9	44	2009-07-27 13:17:44	2009-07-27 14:17:44	3	2	29	8	32	42	3	442.20	49	99.39	CHANGED	ulK+aTcMAYsSADDMlFGpuhaPVKsGhslcIGAGhshPElNhA..PRstutpSh-cLl+EYc+IssDshpRhlplGhPulllEsEHVpQMopsP-WGuclA+sQ+shME-aHDcYGlKsuLRpTluDIREsc-hhtLR.GDphsshhEuFEpCApNGADhLSlEShGGKEVaDYuIlRNDlsGlLauIGlLGolDMEalWscIucIAKKpssluuGDTDCAQANTAMFlAGGLhsKNluHTlAslARAISAsRSLVAYEsGAlGPGKDCGYENsIlKAIuGVPIutEGKoSTCAHSDlMGNLshpsCDlWSNESVEY+tEFGGTTstsWsEoLuYDCALMNTAhphGppKsL..RDhhhlSD+YRDPQuYlLAYDNAY+lGcAIVK-GcDIYLRuKsAAlcsspIlcEGh.cG+LcLoRFE+cuLsssppslEuLsDDpDcFhp-ClpKYtpcVKsF+PEsYs	..h.hp+aTcMAYssuD-MlFGpuKpPVKsGhGhpIGuGhshPElNhA..P.t..tutpSh-KllpEYccIspslhpRhlplGhPulllEpEHVtQhopNPcWGu-lspsp+slME-YHDcYGlKsuLRpT.uDlREpcch.pLR.G-passhhEuFEtCApsGADhLSlEShGGKEVaDaullRsDhtulLauIGVLGohDMEhlWp-IscIAcKssslsuGDTDCuQANTAMFlAGGLhcKsluHThAslARAIuAsRSLVAaEsGAhGPsKDCGYENsIlKAIsGlPIutEGKousCAHSDlhGNLshtsCDlWSNESVEa+tEhGGsTspsWhEsLuYDCuLMNsAlppGppK.L..RDhhshSD+YRDPQuYlLuYDNAY+IGpAIl+sGcshYLRuKsAAlc.shpllc-us.sG+LpLoRFEpcsLspsppslEuLsDDp-cFhs-slp+YppcVchFcPpsYs..........	0	8	24	27
+12010	PF12177	Proho_convert		Prohormone convertase enzyme	Mistry J, Gavin OL	lg7	pdb_2ke3	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF01483, Pfam:PF00082. There are two completely conserved residues (Y and D) that may be functionally important. This protein is the C terminal domain of a prohormone convertase enzyme which targets hormones in dense core secretory granules. This C terminal tail domain is the domain responsible for targeting these dense core secretory granules. The domain adopts an alpha helical structure. 	25.00	25.00	28.20	59.10	19.90	18.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.96	0.72	-4.37	3	51	2009-07-27 13:18:22	2009-07-27 14:18:22	3	1	38	2	24	52	0	41.00	76	5.49	CHANGED	phKDsEDSLYNDYlDsFYNsKPYKHRDDRLLQALl-Ils-D	..QLKDSEDSLYsDYVDVFYNTKPYKHRDDRLLQALVDILsEE..	0	1	3	10
+12011	PF12178	INCENP_N		Chromosome passenger complex (CPC) protein INCENP N terminal	Mistry J, Gavin OL	lg7	pdb_2qfa	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.	20.60	20.60	21.90	20.80	18.30	18.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-7.65	0.72	-4.41	7	80	2009-07-27 13:21:03	2009-07-27 14:21:03	3	2	45	1	33	72	0	37.40	46	4.94	CHANGED	spuhtpLhplhspKlt-FlsplDshchlWL-EIppEAt	..t.Gsh+LLElC-pKLhEFlsshDNKDlVWLEEIpEEAt..	1	2	6	17
+12012	PF12179	IKKbetaNEMObind		I-kappa-kinase-beta NEMO binding domain	Mistry J, Gavin OL	lg7	pdb_3brt	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.	25.00	25.00	25.90	25.70	24.50	18.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.65	0.72	-4.13	9	110	2009-07-27 13:23:03	2009-07-27 14:23:03	3	3	39	6	48	84	0	37.60	47	5.40	CHANGED	SE-LltEuhsLCspLEoslp-sh+EQ-pSlhuLDWSWL	.....tplltEshshhupLpohlp-....sscEQspShMsLDWSWL....	0	2	5	14
+12013	PF12180	EABR		TSG101 and ALIX binding domain of CEP55	Mistry J, Gavin OL	lg7	pdb_3e1r	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.	25.00	25.00	25.00	25.00	19.50	23.70	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.68	0.72	-4.60	6	110	2009-07-27 13:23:54	2009-07-27 14:23:54	3	1	43	2	55	98	0	34.90	50	8.56	CHANGED	cppl+cs.-hNppW.pYDppREsYV+uLhs+lKEL	...cpplpc.s.-hNtpW.pYDtpR-tYV+GLhAplhEh....	0	4	8	21
+12014	PF12181	MogR_DNAbind		DNA binding domain of the motility gene repressor (MogR)	Mistry J, Gavin OL	lg7	pdb_3fdq	Domain	This domain family is found in bacteria, and is approximately 150 amino acids in length. MogR is involved in repression of transcription of the flagellar gene in Listeria bacteria. This allows a phenotypical switch from an extracellular bacterium to an intracellular pathogen. MogR binds AT rich flagellar gene promoter regions upstream of the flagellar gene. These regions follow the pattern 5'-TTTTNNNNNAAAA-3'. This domain is the DNA binding domain of MogR.	25.00	25.00	83.10	82.90	21.60	20.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.88	0.71	-4.43	4	125	2009-07-27 13:24:16	2009-07-27 14:24:16	3	1	120	2	5	94	0	143.50	71	47.21	CHANGED	LLQNMSNsKpNDhpLEu.EFKKIEKQFQVcYEELlDLYNRMVLFQIDIEKpGGMcsYEKSsITWLKSELELLYtVYQFsQRHsLNIhNISKYlSKpELNLF.KTESQLQNTYYKLKKpEIPFENIcKQKPGRKRKYssVKET.sEhKpE	.LLQpMSNNKhNDhpLEs.EhKKIEKpFpVcYEELlDLYNRMVLFQIDIEKHGGhRAYEKSsITWLKSELELLYEVYQFsQRHGLNIlNISKYVSKNELNLFPKTESQLQNTYYKLKKcEIPFENIEKQKPGRKRKYhPVKETlVphKpE.............	0	1	3	3
+12015	PF12182	DUF3642	Lipoprotein;	Bacterial lipoprotein	Mistry J, Gavin OL	lg7	pdb_3ge2	Domain	This domain family is found in bacteria, and is approximately 60 amino acids in length. There is a single completely conserved Y residue that may be functionally important. This domain is from a bacterial lipoprotein, a major virulence factor in Gram negative bacteria.	22.70	22.70	23.90	23.00	22.30	19.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.60	0.72	-3.55	10	315	2012-10-03 08:47:39	2009-07-27 14:26:22	3	1	274	1	16	161	0	78.20	62	47.50	CHANGED	spsoslDGoYsusD.-s....DQlTLploGsoGThTclEsDG-cElcQVss-usNQ+LII...GD.DsKpYphsGNQLsl-DhDc-s	......AQPT-IDGTYTGQD.DG....D+ITLVVTGTTGTWTELESDGDQcVKQVTFDuANQRMII.....GD.D..VKIYTVNGNQllVDDMDRDP...................	1	1	3	7
+12016	PF12183	NotI		Restriction endonuclease NotI	Mistry J, Gavin OL	lg7	pdb_3bvq	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 270 and 341 amino acids in length. There is a conserved CPF sequence motif. The type IIP restriction enzyme, NotI, is a homodimer that recognizes the 8 bp DNA sequence 5'-GC/GGCCGC-3' and cleaves both strands of DNA to create 5', 4 base cohesive overhangs.	25.00	25.00	62.30	62.10	19.30	18.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.90	0.70	-5.30	13	53	2012-10-11 20:44:46	2009-07-27 14:38:24	3	1	49	4	17	50	1	226.60	26	80.31	CHANGED	ElFGaps..ss.u.hsspppupct.CPFh.spps.KsoKspst.shGVCSl...h..........scsupslIlCPhR.atpchpIhs-suchhhs...................h.tuhhhthtpththssshGcs...sGsEh.ls...t.....lDalLsphss....G+lhDaVulElQslshoGsh+shhpph.............hppspuphuhsW............osstKRllPQLhaKGsllc+.....hstKhshllpcshathlsc.h................lspht.hpsushsa.hlh-hc.sss....t.thpL	........................EhhG.th..s..t..h..hthhtp..CPFh.sppC.K.spKsps....GsCol.....h...................tpssp.hIlCPhR.hhp....chphhhpshphhhs............................................t+p...sGsElpls......t.sth.lDalLsshss....sclhDaVulElQslspTGss.ts.ppphht...........hppstsphuhs.W............psstKRllsQlhhKsplhcp.....hstKhshllppthathhsp.h................htphp..hpttshsh.hhhshc.stp...............................................................	0	3	7	16
+12018	PF12185	IR1-M		Nup358/RanBP2 E3 ligase domain	Mistry J, Gavin OL	lg7	pdb_1z5s	Domain	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00638, Pfam:PF00641, Pfam:PF00160. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.	25.00	25.00	25.00	25.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.07	0.72	-4.25	4	96	2009-07-27 15:58:16	2009-07-27 16:58:16	3	30	40	4	59	87	0	62.00	51	4.32	CHANGED	Ds.IVaE+cPTsEpcAhAcpLpLPPTFFChhspsD.ospDpscsEDF-otV+KlptcLhspssEt	...-slIVaEtpPTsEpKAhAcpL+LPPTFFChhsts...D..ssE-p..pssEDFpotl+Klptt.h.pspc.t........	0	8	12	29
+12019	PF12186	AcylCoA_dehyd_C		Acyl-CoA dehydrogenase C terminal	Mistry J, Gavin OL	lg7	pdb_2oku	Domain	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF02770, Pfam:PF00441, Pfam:PF02771. There is a conserved ARRL sequence motif. The C terminal domain is an alpha helical domain. The flavin ring of Acyl-CoA dehydrogenase is buried in the crevice between the two alpha helical domains and the beta-sheet domain of one subunit, and the adenosine pyrophosphate moiety is stretched into the subunit junction of a neighbouring subunit, composed of two C terminal domains.	19.80	19.80	20.50	21.20	19.30	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.37	0.71	-4.22	7	120	2009-07-27 15:59:57	2009-07-27 16:59:57	3	2	119	2	18	101	7	112.90	46	19.94	CHANGED	TsGoYlApIR.EapslsssPEhpsLps+LtcMss+a-AssstVpEspDQELlDFhARRLhEMAAchlhuHLLlQDAsKs.D.FtcSApVYlpYupAEl-KapsFIppFst-DLAh	.............TNGoYlupl+.E.apphss..usE.hpsLhsRlpcMss+aEsssstVK..EspsQE...l...hDFhARRLhEMAAclIMuaLLlpDAo.KusELFuKSApVYlpaAEuEVpKHtsFIcsFcsEDL...........	0	9	16	18
+12020	PF12187	VirArc_Nuclease		Viral/Archaeal nuclease	Mistry J, Gavin OL	lg7	pdb_2w8m	Domain	This family of proteins is found in archaea and viruses. Proteins in this family are typically between 211 and 244 amino acids in length. These proteins are nucleases from fusseloviruses and sulfolobus archaea.	19.70	19.70	19.90	20.90	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.27	0.71	-4.89	4	13	2012-10-11 20:44:46	2009-07-27 17:00:09	3	2	13	2	3	15	1	174.20	44	76.43	CHANGED	sFK.+YWuNps.-sa.lPs.aLGREYLlhGhLhIpLtpW+.KGLlcFDlYl+.TGlGTLTsVINcpYYpsl.DKYDLTlYh+hK....spYaPhlaIDlTGSSWTEEQSccR.....YGEulYAILSsKVpVApph-VhG.RshFIHYsDpEDKLKhIsALpILNLE+QGK...I+h-caEhsAtSpYYlIPlphWKNls-LRV	....................................FKLKYWGspt.-sYlLPs.hLGREYLllGKL.hIpLupW+.KGhl-aDlYl+.oGlGTLT.NsIN.pYYcslpDKYDhTlYl+sK....cpYaP..LlaIDITGSSWTEEQSccR.....YGESlYAILSsKV-VApcas..VhG.RVaFlHYsDsEDKLKsIoALQILNLE+psK...IKhDcFEpsAtSpYYLIPlphWKNlhELR...........	1	1	1	3
+12021	PF12188	STAT2_C	STAT2_Cterm;	Signal transducer and activator of transcription 2 C terminal	Mistry J, Gavin OL	lg7	pdb_2ka4	Domain	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. There is a conserved DLP sequence motif. STATs are involved in transcriptional regulation and are the only regulators known to be modulated by tyrosine phosphorylation. STAT2 forms a trimeric complex with STAT1 and IRF-9 (Interferon Regulatory Factor 9), on activation of the cell by interferon, which is called ISGF3 (Interferon-stimulated gene factor 3). The C terminal domain of STAT2 contains a nuclear export signal (NES) which allows export of STAT2 into the cytoplasm along with any complexed molecules.	20.00	20.00	76.60	75.30	19.70	16.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.65	0.72	-4.17	5	42	2009-07-27 16:00:45	2009-07-27 17:00:45	3	5	23	1	11	33	0	56.00	62	7.09	CHANGED	SQPlPEPDLPcDLQQLNT--M-IFRNslsIE-IMPNGDPLLAGQNo.VDEAYlSppS	......SQslPEPDLPpDLRHLNTE-ME...IFRNs.h+IEEIMPNGDPLLAGQNT.sDEsalsp.S...	1	1	1	1
+12022	PF12189	VirE1		Single-strand DNA-binding protein	Mistry J, Gavin OL	lg7	pdb_3btp	Domain	This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved IELE sequence motif. VirE1 is an acidic chaperone protein which binds to VirE2, a ssDNA binding protein. These proteins are virulence factors of the plant pathogens Agrobacteria. VirE1 competes for the ssDNA binding site of VirE2.	25.00	25.00	26.10	101.90	17.80	16.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.00	0.72	-3.85	4	9	2009-07-27 16:02:35	2009-07-27 17:02:35	3	1	5	1	3	6	0	62.30	61	95.08	CHANGED	MAIIKLpsNKsRsssssEcPpEl.tEEhShsH.ssGFTsLDLcMIELEsFVL+CPLPE-NLAG	MAIIKLpANKNRsssssEcPpcl.hEEhSssa.ssGFTSLDLcMIELEsFVL+CPLPE-NLAG	0	1	3	3
+12023	PF12190	amfpi-1		Fungal protease inhibitor	Mistry J, Gavin OL	lg7	pdb_3bt4	Family	This protein family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are fungal protease inhibitors.	25.00	25.00	25.20	29.30	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.44	0.72	-3.48	2	9	2009-07-27 16:04:19	2009-07-27 17:04:19	3	1	6	1	2	11	0	85.00	68	91.29	CHANGED	Csht..YGsLVCGosYCcppPChpP.h...C.pso.aRA+HAGKCACCPACVThLGEsAsCKhYSKELGETPSAlC+-PLKClptVCT+ls	.Clhs..YGsLVCGTsYCcpNPChpPshs..C.pso.aRA...pHAGKCACCPACVTLLsEsAsCKhYSKELGETPSAVC+EPLKClptVCTKls.	0	1	2	2
+12024	PF12191	stn_TNFRSF12A		Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain	Mistry J, Gavin OL	lg7	pdb_2eqp	Domain	This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumour necrosis factor receptor. The function of this domain is unknown.	21.40	21.40	21.40	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.79	0.71	-4.10	2	45	2009-07-28 09:54:12	2009-07-28 10:54:12	3	2	30	4	23	46	0	108.70	54	87.92	CHANGED	MsP...RsL.phhV.hhhLVL......ppAsupu.CspGpuaStDLsKCM-CusC.sp.+SDFC.sCsuts.t..F.hlWsIhhuAhulhLllsllShhlhhp+CRR+pKFTTPIEETGucus.ul.LIp	..........................L.thLVhshhLsL.tusuG.ppsPGsuPCucGoSWSuDLD.KCMDCuSC.uRP+SDFChGCuAAPPAs..FpLLWPILGGALSLs..lV.LuLLS.GFLVWRRCRRREKFTT.PIEETGGEGCPuVALIQ......................................................................	0	7	7	10
+12025	PF12192	CBP		Fungal calcium binding protein	Mistry J, Gavin OL	lg7	pdb_2jv7	Domain	This domain is found in eukaryotes, and is approximately 60 amino acids in length. There is a single completely conserved residue C that may be functionally important. This is a calcium binding domain from the fungal protein CBP (calcium binding protein). This protein is a virulence factor with unknown virulence mechanisms. CBP complexes as a highly intertwined homodimer. Each monomer is comprised of four alpha helices which adopt the saposin fold, characteristic of a protein family that binds to membranes and lipids.	25.00	25.00	59.60	58.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.86	0.72	-4.02	5	12	2009-07-28 09:54:30	2009-07-28 10:54:30	3	2	11	2	8	14	0	57.20	47	25.99	CHANGED	QPuVscAhs.aNpsVssFpKAouAAuCsWlsCluSLuuoSAACAAAluELGLcPPsDLA	.......tPultcAhspaNpsVssFpcAouAAuCsWlsClpSLuuoSAACAAAluELGLs..hDhA......	0	1	2	5
+12026	PF12193	Sulf_coat_C	Sulf_coatprot_C;	Sulfolobus virus coat protein C terminal	Mistry J, Gavin OL	lg7	pdb_3f2e	Domain	This domain family is found in viruses, and is approximately 70 amino acids in length. It is the C terminal of a coat protein in sulfolobus viruses.	25.00	25.00	38.40	136.40	22.50	17.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.44	0.72	-4.16	3	5	2009-07-28 09:55:13	2009-07-28 10:55:13	3	1	5	1	0	5	0	69.00	86	54.25	CHANGED	VSAVLTQYGITGPNRAIYQGFGLKVARALNRIGSGPALVNMINGLKuYYISAFNANPQVLDAVVNIITG	VSAVLTQYGITGPNRAIYQGFGLKVARALNRIGSGPALVNMINGLKAYYISAFNANPpVLDAVTNIITG	0	0	0	0
+12027	PF12194	Ste5_C	ste5minscaffold;	Protein kinase Fus3-binding	Mistry J, Gavin OL	lg7	pdb_3fze	Domain	This domain family is found in eukaryotes, and is approximately 190 amino acids in length. This domain is the penultimate C terminal domain from the protein ste5 which co-catalyses the phosphorylation of fus3 by ste7. It is involved in the MAPK pathways. This domain is the minimal scaffold domain of ste5. It binds to the mitogen activated protein kinase fus3 before it is phosphorylated.	25.00	25.00	185.80	185.00	22.50	17.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.08	0.71	-4.67	5	22	2009-09-14 13:25:02	2009-07-28 10:55:46	3	2	21	1	12	24	0	192.70	54	22.33	CHANGED	hTSISSILSLKRE+P--LsLlLQIDppKlp.-DshI..lItNoLpALshKFsshphClVDusGhVlshGols+hI.sLsSIus.hc+ssusp+FSPshL+splY..spsIpcNLGIVllSNSuMEpuKSlLFpDY+sFsShGRRRPNELKIKVGYLNsDYSDpIsELVEIuoWsalLEALCYSFuLSFDDDD..DD-Es	h.TTISSILSLKRE+PDsLsIlLQIDFpKLKp-csll..llYNSLKALolKFscLphChVDpsshVlsaGslhctIssl-ulss.LcppsuuppFSPhWLKNoLY..PcsI+cpLGIlslSNSsMEscKSlLF.DY+sFsuhGRRRPNELKIKVGY..LNVDYSDKIsELVEsuSWshlLEoLCYSFuLuFD-DD..DD--.....	0	1	6	12
+12028	PF12195	End_beta_barrel	Endosialidase; Endobetabarrel;	Beta barrel domain of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is approximately 80 amino acids in length.This domain is the beta barrel domain of bacteriophage endosialidase which represents the one of the two sialic acid binding sites of the enzyme. The domain is nested in the beta propeller domain of the endosialidase enzyme. The endosialidase protein complexes to form homotrimeric molecules.	26.50	26.50	28.40	34.90	24.10	26.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.85	0.72	-4.25	3	30	2009-07-28 13:31:40	2009-07-28 14:31:40	3	9	26	18	2	27	19	83.00	73	8.81	CHANGED	SRSLHlTGGITKAANQpsATI+IsDHGLFAGDFVNFSNSAVTGVSGNMTVATVIDKNTFTVTTsNsQsSDlNNAG+sWsFGTS	.........SRSLRlYGGITKAANQQVAYIRITDHGLFAGDFVNFSNSGVTGVTGNMTVTTVIDKNTFTVTTQNT.....QDVDQNNEGRYWSFGTS.......	0	0	0	0
+12029	PF12196	hNIFK_binding		FHA Ki67 binding domain of hNIFK	Mistry J, Gavin OL	lg7	pdb_2aff	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00076. There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.	25.00	25.00	29.00	27.90	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.11	0.72	-4.57	5	73	2009-07-28 13:32:34	2009-07-28 14:32:34	3	2	40	1	31	53	0	39.30	63	14.58	CHANGED	SVsSQDPTPVCTPTFLERRKSQlhEl..sDD-cDDEIVLKLPl	......oVDSQGsTPVCTPTFLERRKSpVA-h..NDDDcDs.EIVFKpP....	0	1	2	9
+12030	PF12197	lci		Bacillus cereus group antimicrobial protein	Mistry J, Gavin OL	lg7	pdb_2b9k	Domain	This domain is found in bacteria, and is approximately 40 amino acids in length. This domain is found in bacillus cereus group bacteria. It is an antimicrobial protein.	20.30	20.30	20.70	20.40	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.12	0.72	-4.37	4	37	2009-07-28 13:32:52	2009-07-28 14:32:52	3	1	31	1	9	30	0	38.90	38	34.23	CHANGED	s.hhlpSssGsFANSFspsGsTWYhKGK.hpsspGsWsuaYE..s+	...............pssG.FAssF.t.s....G..hpWYhKG...t.hc..scGpWsGaYE....t....	0	2	4	5
+12031	PF12198	Tuberculin		Theoretical tuberculin protein	Mistry J, Gavin OL	lg7	pdb_2g6r	Domain	This domain family is found in bacteria, and is approximately 30 amino acids in length. This protein is a theoretical model of the tuberculin protein from Mycobacterium tuberculosis.	25.00	25.00	83.90	64.50	18.90	16.30	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.30	0.72	-4.06	2	6	2009-07-28 13:34:07	2009-07-28 14:34:07	3	2	2	0	0	6	0	34.00	77	21.36	CHANGED	ohtplspsuGutS.u+NGsQhRhlAssGPtSuTh	SLASVSSVSGGGSVSRNGNQARFVAPTGPASSTF	0	0	0	0
+12032	PF12199	efb-c		Extracellular fibrinogen binding protein C terminal	Mistry J, Gavin OL	lg7	pdb_2gox	Domain	This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	21.40	21.40	21.50	21.80	21.20	19.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-9.08	0.72	-4.12	2	315	2009-07-28 13:34:20	2009-07-28 14:34:20	3	1	161	12	2	47	0	64.70	69	47.90	CHANGED	TshphphppKllpAQphVp.Fc+T+TVusHRKAQ+AVNLlpFpaphcKhhLQcpID.VLK.shl+	..TshphphppKllpAQphVp.Fc+T+TVusHRKAQ+AVNLlpFpashcKhhLQcpID.VLK.shlK.....	1	2	2	2
+12033	PF12200	DUF3597		Domain of unknown function (DUF3597)	Mistry J, Gavin OL	lg7	pdb_2gqb	Domain	This family of proteins is found in bacteria, eukaryotes and viruses.  Proteins in this family are typically between 126 and 281 amino acids in length. The function of this domain is unknown. The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two.	23.50	23.50	23.50	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.75	0.71	-3.75	24	206	2009-07-28 13:34:35	2009-07-28 14:34:35	3	7	187	1	69	167	11	119.50	50	74.91	CHANGED	IFupIhstIF..........ucutsAsPsusssssssssuss...................suP...ussPsu................ssVDVuslL-thssp.pup+LsW+TSIVDLMKhLslDSSLsuRKELApELGYoGD.psDSAsMNIWLHKQVMpKLAtNGGKlP	...................................................IFspIhstIa.............ucups..A.s.ss...utssss.s...sss.s.sssss.....................uAs......ussPsu............................ssVDVsAlL-shstp...suptL...NW+TSIVDLMKhLGLDSSLptRKELApELGYo.GD..hsDSAoMNlWLHKpVhpKLt-NGGKlP........	0	8	33	51
+12034	PF12201	bcl-2I13		Bcl2-interacting killer, BH3-domain containing	Mistry J, Gavin OL	lg7	pdb_2ipe	Domain	This is a family of pro-apoptotic Bcl-x proteins, B cell leukaemia/lymphoma 2, or BIKs.  BIK proteins rely for their activity upon an intact BH3 domain lying between residues 48 and 80, as in UniProt:Q13323.	25.00	25.00	41.10	40.70	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.01	0.71	-4.76	2	21	2009-07-28 13:35:07	2009-07-28 14:35:07	3	1	19	0	10	21	0	135.00	52	98.40	CHANGED	MSEsR.huRDl.hcTl.a-Ql.pPPsh.Es.uMp-......PhcDhD.hEChEGpstlALRLACIGDEMDlsLRuPRLsQLstlAhHp..LAhhYspT.slRslhRShhcuhTsL+ENIhp.WRs.sPGuWVSs-Qs.htLh.hlhLlh.LLuGuhaL.L	....MSpsRPloRDhhh-TlLaEQl.pP.sh.Es.G.ho-.....tEshsPhc..Dhs.hEChEssDtlALRLACIGDEMDVsLRuPRLAQLstlAMHS..LAhhYsQT.slRsVLRShhcGhTsL+ENIhp.WRs.sstuWVo...........p.s...h.lh.hlhLlh.hh...........................................	0	1	1	2
+12035	PF12202	OSR1_C		Oxidative-stress-responsive kinase 1 C terminal	Mistry J, Gavin OL	lg7	pdb_2v3s	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00069. There is a single completely conserved residue F that may be functionally important. OSR1 is involved in the signalling cascade which activates Na/K/2Cl cotransporter during osmotic stress. This domain is the C terminal domain of OSR1 which recognises a motif (Arg-Phe-Xaa-Val) on the OSR1-activating protein WNK1.	25.00	25.00	26.60	26.10	23.10	22.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.49	0.72	-4.32	16	453	2009-07-29 08:07:16	2009-07-29 09:07:16	3	6	84	3	231	395	0	35.70	50	2.76	CHANGED	lpLhLRlc-sKKhtt.+.K-NpAIcFpFslt+DssE-VA	.......lpLhLRlcDsKK.tt.+.+-NpuIcFpFslt+.DssE-VA....	0	35	56	140
+12036	PF12203	HDAC4_Gln		Glutamine rich N terminal domain of histone deacetylase 4	Mistry J, Gavin OL	lg7	pdb_2o94	Domain	This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.	25.00	25.00	26.20	26.20	22.70	24.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.60	0.72	-4.05	6	235	2009-07-29 08:07:40	2009-07-29 09:07:40	3	4	46	8	78	202	0	86.40	69	9.97	CHANGED	ssDPslREpQLQQELLLlpQQQQIQKQLLIAEFQKQHEpLTRQHpAQLQEHLK.QQELLAhK+QQELhE+cRKLEQQRQEp........ElE+HRREQQL	........sDPslREpQLQQELLhlpQQQQlQKQLLIAEFQKQHEpLTRQHpAQLQEHl.K................QQ..Eh.........L.A.........hKpQQ.ELL.E..+ppKLEQpRQEQ.........ElE+p+REQpL.........................	0	5	12	36
+12037	PF12204	DUF3598		Domain of unknown function (DUF3598)	Mistry J, Gavin OL	lg7	pdb_2o62	Domain	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 230 and 398 amino acids in length. These proteins are formed entirely from B sheets which form a barrel structure similar to those seen in the lipocalin superfamily.	21.20	21.20	21.30	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.69	0.70	-5.15	18	117	2009-07-29 08:08:10	2009-07-29 09:08:10	3	3	73	2	52	123	46	228.00	22	76.76	CHANGED	spW-shh.pNLGE...WpGSFTchSPpG...-llpshsSlloLpuhsc.sphl+hslthas............pts.sp-hspcasulu......pphlaFss.GAFSpGshQLuPaucFuuEhGFlpcsRRhRlV.lascsGpLscloLIREahuus....susEpPsLps-p....LLGpWpGcshohhPDh..p.sph..hph.l.......................tsuslpusthha.tspp..spl.hhLPDGsusssPpplph.....cpsFhlElGWLlpssp...hpRllRpYsspGpWhuloLls.p	...............................................................................................................................hh..ph...tt....W.G.ah.hs.tt....p....pph..shhphp..........t..hp.....h.h...............................p........pth...........thhhh.s.Gsh.s.s...s.tht.....t.....................h.hh.....E.hhh..h..pt..s..pRhRh.shh..a........stpG...p.........LpplshlcEppsst..............sstpps.lp...pp.......h.hGpWpGpthohhs.sh.........h...............................................psthpsphh.hh.tt........ph.hhLPsGh.hssP....tplth.....tpsF.lphsWl.pssp...hpRllRsYsspG.hhu.ohhh..t................................................................................	2	11	33	45
+12038	PF12205	GIT1_C		G protein-coupled receptor kinase-interacting protein 1 C term	Mistry J, Gavin OL	lg7	pdb_2jx0	Domain	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF01412, Pfam:PF00023, Pfam:PF08518. GIT1 plays an important role in cell adhesion, motility, cytoskeletal remodeling and membrane trafficking. To perform this function, it localises p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulated by interaction between its paxillin-binding C terminal and the LD motifs of paxillin. The C terminal folds into a four helix bundle.	25.00	25.00	25.20	26.70	22.70	21.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.54	0.71	-4.28	5	199	2009-07-29 08:09:01	2009-07-29 09:09:01	3	11	78	1	86	202	0	120.70	62	17.57	CHANGED	-u-sDssLPSTEDVIRKTEQITKNIQELLRAAQEsKH-SFVPCSE+IalAVsEMAuLFPKRPssEsVRsSLRLLsSSAsRLQsECKKAsP.-..tssDhphlTQQVIQCAYDIAKAAKQLVTlTT	...............s....sPsLPSTEDVIpKTEQlTKNIQELLRA...AQ...E.s...K.HD.S.al.P.CSE+IHlAVTEMAuLF.P...K+.P..t..p.-.sVRoS...LRLLsuSAYRLQSEC....+Ksl...Ps-s........usssDhQLl..TQ...QVIQCAYDIAKAAKQLVTITT............................................	0	21	28	49
+12039	PF12206	DUF3599		Domain of unknown function (DUF3599)	Mistry J, Gavin OL	lg7	pdb_3f3b	Domain	This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. This domain is the phage-like element pbsx protein xkdh.	25.00	25.00	37.60	119.80	24.20	22.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.54	0.71	-3.83	7	38	2009-07-29 14:17:48	2009-07-29 15:17:48	3	1	33	1	5	32	0	117.30	49	97.21	CHANGED	MSYpphLs+RCDIYHLtppcsptt.+aGIPucclp..hpYsDTPDlpslsCYFhEKsp....ollQpEPppslhpSaLlHFPhssDIRhpDKslhc..GhsahLppP.+tl+sHHhEVhAlRcpp	.MSYpphLsHRCDIYH.ttptspsG.+FGIPu-clpP.hoYP-oPDhpclPCYFsEKsQ....plIQpEPspslYQpaLVHFPhsADlRlNDKllWc..shsYhLchP.+pl+s.HHhEVhAVR--.p.	0	2	3	4
+12040	PF12207	DUF3600		Domain of unknown function (DUF3600)	Mistry J, Gavin OL	lg7	pdb_3fgg	Domain	This family of proteins is found in bacteria. Proteins in this family are approximately 230 amino acids in length. This domain is the C terminal of the putative ecf-type sigma factor negative effector.	25.00	25.00	25.70	40.90	23.30	22.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.06	0.71	-4.70	6	85	2009-07-29 14:18:26	2009-07-29 15:18:26	3	1	85	4	6	63	0	158.60	80	75.11	CHANGED	SIMADGIYGSFENLKKHAGsMTLEuYMRFsAKLSEAKDEMGTKEYE.FTKELKKLTNAKLAYGDSNGNIDYDuLSPAKREEMKKVSMuLQPYFDKLNGHKSSKEVLTQEEFDRYMEALMTHEIVRVKTKSTGAIKVEEVPEAYKERFIKAEQFMEYVDEKVR	..SIMADGIYGSFENLKKHAGsMTLEAYMRFsAKLSEAKDEMGoKEYE.FTKELKKLTNAKLAYGDSNGNIDYDtLSPsKREEMKKVoMsLQPYFDKLNGH..KSSKEVLTQEEFDpYMEALMTHEIVpVKTKSTGuIKVEElPEAYKERFIKAEQFMEYVDEKVR........	0	1	4	5
+12041	PF12208	DUF3601		Domain of unknown function (DUF3601)	Mistry J, Gavin OL	lg7	pdb_3g1j	Domain	This domain family is found in bacteria, and is approximately 80 amino acids in length.	21.00	21.00	21.00	24.30	20.50	18.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.55	0.72	-4.04	6	50	2009-07-29 14:46:14	2009-07-29 15:46:14	3	1	32	2	6	48	0	82.00	55	54.34	CHANGED	s..phLhsGshV+VIKsF+DYhGhTapsGEpaaFAsshahPY-sGaTLYI..up-K....sIhLpsps-sptcIhsps.cEYFE.lp	..sF.cYLYSGDYlKVIKsFKDYYG.FTHpsGEcaYFAstYaL.aEsGhsLYI...SpDKlN...........lssIYLpDRt-s........p.clhsHs.EEYFEIlE.................	0	6	6	6
+12042	PF12209	SAC3		Leucine permease transcriptional regulator helical domain	Mistry J, Gavin OL	lg7	pdb_3fwc	Domain	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF03399. This domain is a helical domain in the middle of leucine permease transcriptional regulator.	25.00	25.00	32.80	31.80	23.10	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.49	0.72	-3.84	10	37	2009-07-29 14:46:34	2009-07-29 15:46:34	3	1	36	5	26	41	0	77.90	28	6.27	CHANGED	llpQlhsplhp-sIcsplpshlpshlpctpt+pp+ppl.IsoLScELacAFl+EplYhshLES+A-.ahs+hlKK+hhc+	.........h.hcplhspllppsVpsplpsllpp..hlpctptc..pt+tpl.IcoLucELYsAFl+EplYhhhl-o+A-.hhppplK++hhp.....	0	4	15	26
+12043	PF12210	Hrs_helical		Hepatocyte growth factor-regulated tyrosine kinase substrate	Mistry J, Gavin OL	lg7	pdb_3f1i	Domain	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00790, Pfam:PF01363, Pfam:PF02809. This domain is the helical region of Hrs which forms the core complex of ESCRT with STAM.	22.40	22.40	22.70	34.20	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.09	0.72	-3.73	5	116	2009-07-29 14:46:51	2009-07-29 15:46:51	3	7	82	1	70	114	0	93.20	61	13.22	CHANGED	EcFlsNlRouVElFsNRM+SNpuRGRSIuNDSAVQoLFQolosMHPQLLchlcpLDE+RhaYEuLQDKLuQI+DARAALDuLREEHcEKLR.RtAEE	......-pFlcuLpsuVosFVNRMKSNphRGRSIoNDSAV.oLFpoIssMHPQLLchlppLDE+RlYYEGLQDKLAQIRDARuALsALR-EHcEKLR.RtAEE.......	1	23	27	52
+12044	PF12211	LMWSLP_N		Low molecular weight S layer protein N terminal	Mistry J, Gavin OL	lg7	pdb_3cvz	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 328 and 381 amino acids in length. There is a conserved LGDG sequence motif. Clostridial species have a layer of surface proteins surrounding their membrane. This layer is comprised of a high molecular weight protein and a low molecular weight protein. This domain is the N terminal domain of the low molecular weight protein. It is a structural domain.	25.00	25.00	48.70	42.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.82	0.70	-4.54	19	115	2009-07-29 14:48:39	2009-07-29 15:48:39	3	2	9	4	1	110	0	234.00	34	61.87	CHANGED	spsYTVVQscYcKslKplQcGlpcssIosIsVhFD.Gp.ls..sVssttsssp.......AAspLhshV-sKLDsLGDGcYVDFpIoYssssphhT.ps-ls...shtstls....sclllssAss..sss...Gllh...tssssssssuAssslphSDlhchsh...ssspsuhpLohsspt.sshphGpl...........sssshssupslohsss..htlshucu.cplDlspShhhssssu.........hhsspssssssssspspVRVINAKEpTIDlDuSShpoAE	......................................sYTVVQscYcKslKplQcGlpcssIopltV.F-.Gp.lu..pVsstsssuc..t....AAcpLhshVcspLDsLGDG-YVDFpITYs....s....tschhT.pu-hc...shtspls....s+llIssAos.....ost.....GhVp...tssssspt.uAssslphuDhhphsh..sssspsuhploh.sstt.sshphGpl............tss.os.u.tslshsss.th.hthucs.chlDhs.....pShhhsssss.........hhsstsss.sssssspspVRVINAKEpTIDlDuSShpoAc.....	0	1	1	1
+12045	PF12212	PAZ_siRNAbind		Piwi/Argonaute/Zwille siRNA-binding domain	Mistry J, Gavin OL	lg7	pdb_3da5	Domain	This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There is a conserved LKDIL sequence motif. There is a single completely conserved residue L that may be functionally important. This domain is part of an Argonaute protein. It is an siRNA binding domain.	21.10	21.10	21.10	21.90	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.15	0.72	-4.34	10	42	2009-07-29 14:51:18	2009-07-29 15:51:18	3	6	8	5	16	37	0	45.80	56	46.23	CHANGED	AYAIlp+DSpsIEElL+luKENuILKDILsATtTIKasDucEtThTP	..sYAIhpKcShslEchL+luKENuILKDILsATsTIKYsDupEtThTP....	0	1	15	15
+12046	PF12213	Dpoe2NT		DNA polymerases epsilon N terminal	Mistry J, Gavin OL	lg7	pdb_2v6z	Domain	This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains.	21.50	21.50	21.80	22.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.10	0.72	-4.06	10	117	2009-07-29 14:53:03	2009-07-29 15:53:03	3	4	92	1	78	118	0	70.90	35	13.88	CHANGED	csc+LRp+lsusFKl+GLhLRuEAoKYLs-sLtulscsEhEDhl-+Il-sVcKQPLSSshlEcullEsAVQEC	..........s...tlRp+lhssFKL+GhhLRsEAhcYL...sctL............psh.s..ct.Eh-chL-pll-sl-KQs.LsSshl-+sslEtAlpEC.......	0	24	32	57
+12047	PF12214	TPX2_importin		Cell cycle regulated microtubule associated protein	Assefa S, Gavin OL	lg7	PFAM-B_2368 (release 23.0)	Family	This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with Pfam:PF06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain.	20.30	20.30	20.50	20.30	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.40	0.71	-4.19	10	167	2009-07-31 14:33:35	2009-07-31 15:33:35	3	9	75	0	104	164	0	147.30	34	25.41	CHANGED	s+t+lTsP+EPsLpTupRsRslRsKSsA-LEpEplppl..YKFKAR.lN++IhE.sussl.KKsssK.Ppch.uF+LcTpcRApcRuSsspppspphphpp+ss...hh.DssssPphpshssssP+sstsstcs+pchspp.cc..Kt+PLs.KI...........hcs+tp.u.hsct++ppssPhpFcs	.....................................s...hlTpPppP.LpTppRsRss...p.....sK..Ss.u..E.hEtEpltcl..........KF..K..AR.lsp+IhE..su......h.p+sss+..s.p..tFcL.chp....cRhp....p+pspt.p..t..ppt..........p...p....sp.s..............hh.s.st.s.h..h.hs.sppsthh.p.p.c...tt.......c.t.pPh.....hh............htst.........pt...hs.tF....................................................	0	26	56	72
+12048	PF12215	GBA2_N		beta-Glucocerebrosidase 2 N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2416 (release 23.0)	Family	This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 320 to 354 amino acids in length. This domain is found associated with Pfam:PF04685. This domain is found in the protein beta-Glucocerebrosidase 2. It is found just after the extreme N terminus. This protein is located in the ER. The N terminal is thought to be the luminal domain while the C terminal is the cytosolic domain. The catalytic domain of GBA-2 is unknown.	20.70	20.70	20.70	21.20	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.20	0.70	-5.27	38	367	2009-07-31 14:39:48	2009-07-31 15:39:48	3	14	220	0	196	361	64	289.80	26	35.26	CHANGED	GhPLGGhGuGsIuhus+GchshWpl..csGc.......aha..t.h.........pFula.p.psspstshsLssps.pss...................LssWpa.h........susYpAtYPhuahpac.s.shtsplphEtFSPllPtshpcSShPVAVFpaplpN.ssspslplSlhlSapNslGh.....hs.sptssthhhts.....................h.pssthpGllhps.pstp......spupGphslAs.ss..th...clhtpspWsssu.........sst-lWpsFst...DGpl.....................ptsttscphuuAlulchsltPGpscclsFsluWchPs..h...tFussspth...........+tYocFF..uttsp.sAhslAshALpphppa	.....................................................................GhPLGG.......lGuGsIspu.hcGpFppapl...psu......................................h................sspFslhhp..ps....tt.t.hhh...hs.sps.p.t................................................sltsWpa.hst......................tpspYpuLYPpuWh.Yc........s.....tlplshcthSPllPpsYpcS.ShPsulFhaplpN...s.s.p.hplolhhohp.N.slG...........t.stts.......................................................ttst.hpGllhpp.p........s.............s.......shsluspps...sh..........plshpst.as.su.............supphW..pphtp.....sGph......................................ttsstts..ppl....uuAlssp.htl.........Ptt.spp..lpFsLuWshP......h.......tFststpha............................RpYTcFa..upptp.su.pl....schALpphtph................................................................	0	63	110	161
+12049	PF12216	m04gp34like		Immune evasion protein	Assefa S, Gavin OL	lg7	PFAM-B_2496 (release 23.0)	Family	This protein is found in archaea and viruses. Proteins in this family are typically between 265 to 342 amino acids in length. The proteins in this family are or are related to the m04 encoded protein gp34 of pathogenic microorganisms such as murine cytomegalovirus. m06 and m152 genes are expressed earlier in the intracellular replication phases of these microorganism' life cycles. They function to inhibit MHC-1 loading and export. gp34 is theorized to prevent immune reactions from NK cells which would ordinarily recognise and attack cells lacking MHC.	25.00	25.00	29.40	29.10	23.20	24.70	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.87	0.70	-5.04	11	182	2009-07-31 14:41:40	2009-07-31 15:41:40	3	1	5	0	0	165	0	261.40	22	87.96	CHANGED	hShssR......................hhLlhllhhsshlhssssssspp..................Cp....p.ppthpphhphtps............htCahKctss...sphsss..sss.plhsCpLP...sVhVNAoWolEWll.sslpuSlsshuYapSossSsPpFptshhsah..phh.h....pp.ltsKsGF+VDpSs.....GNLaVasNAo.......ssscuV+C+LphChW..Tossshs..ss.........DcshhpshSsVLsLPDYssP.ths....h.+....ssasasptpps.sss..............lssLoVlVsLlaVsshslLhYhas..........spLhRRhhopDssspa	.............................................................................h.hhhhs.h....hs...h.ssspt..................ss......p..htt.....p...s..........htC.htppss......pphspp..sss.p.hasCpls...slplNAoWpscWll..sshss.......lsstshapSTsoSsPpFpthhsshhs.............sssssGFpVDpss.....GpLalhssss..........tsstslpCpLplClh...........sps.shh..ss..............................................................ppth.pshothhpLssat...t..........................s.ts.h.s.s...tp..thp........................t..hsslslhlshlh..ssshhh..LhhhYt..............s.hhcph.............................................................................................................	0	0	0	0
+12050	PF12217	End_beta_propel		Catalytic beta propeller domain of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is typically between 443 and 460 amino acids in length. This domain is the highly conserved beta propeller of bacteriophage endosialidase which represents the catalytically active part of the enzymes. This core domain forms stable SDS-resistant trimers. There is a nested beta barrel domain in this domain (Pfam:PF12195). The endosialidase protein complexes to form a homotrimeric molecule.	20.30	20.30	21.10	308.50	19.80	17.60	hmmbuild  -o /dev/null --hand HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.39	0.70	-5.77	3	30	2012-10-02 00:45:24	2009-08-03 10:19:26	3	7	24	18	2	29	0	420.90	83	47.65	CHANGED	NGELaKITDTPaYNAWTQDKTFVYDNVIYAPFMAGDRHGVsNLHVAWVRSGDDGQTWSTPEWLTDLHsDYPT......VNYHCMSMGVCRNRLFAVIETRTLSsNKLpsAELWDRPMSRSLHlTGGITKAANQQsATI+IsDHGLFAGDFVNFSNSAVTGVSGNMTVATVIDKNTFTVTTsNsQsSDlNNAG+oWsFGTSFHcSPWRKT-LGpIPS.ssushsVTElHSFATIDDNuF..AVGYHNGDVuPRELGlLYFSDAFsSPGsFVRRpIPuEYEsNASEPCVKYYDGVLYLTTRGTLuTpPGSSLHRSoDlGQoWsSLRFPNNVHHSNLPFAKVGD-LIIFGSERAFGEWEGGAPDsRYcGSYPRTFMsRVNVNsW..SLDDVEWVNITDQIYQGcIVNSAVGVGSVCVKDuWLYYIFGGEDFFNPWSIGDNsuKhPYKHDGHPADLYCYRlKIc	..QGELFKITDTPWYNAWTQDKTFVYDNVIYAPFMAGDRHGVNNLHVAWVRSGDDG+TWTTPEWLTDLHENYPT......VNYHCMSMGVVRNRLFAVIETRTVSGNKLQVAELWDRPMSRSLRlYGGITKAANQQVAYIRITDHGLFAGDFVNFSNSGVTGVTGNMTVTTVIDKNTFTVTTQNTQDVDQNNEGRYWSFGTSFHSSPWRKTSLGTIPSFVDGSTPVTEIHSFATISDNSF..AVGYHNGDIGPRELGILYFSDAFGSPGSFVRRRIPuE.YEANASEPCVKYYDGILYLTTRGTLSTQPGSSLHRSSDLGTSWNSLRFP.NNVHHSNLPFAKVGDELIIFGSERAFGEWEGGEPD...NRYAGNYPRTFMTRVNVNEW..SLDNVEWVNVTDQIYQGGIVNSAVGVGSVCIKDNWLYYIFGGEDFLNPWSIGDNNRKYP..YVHDGHPADLYCFRVKIK..	0	0	0	0
+12051	PF12218	End_N_terminal		N terminal extension of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. This domain is found in the bacteriophage protein endosialidase. The two N-terminal domains (this domain and the beta propeller) assemble in the compact 'cap' whereas the C-terminal domain forms an extended tail-like structure. The very N-terminal part of the 'cap' region (residues 246 to 312) holds the only alpha-helix of the protein and is presumably the residual part of the deleted N-terminal head-binding domain. The endosialidase protein complexes to form homotrimeric molecules.	22.20	22.20	22.40	27.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.26	0.72	-4.50	5	30	2009-12-16 16:06:22	2009-08-03 10:28:11	3	9	25	18	2	27	0	66.00	69	7.08	CHANGED	AlGDGVTDDTsAlousLuuossGpKIDGpGLTYKVSoLPDlSRFKNARFVaERIPGQPLaYVSE-FI	AlGDGVsDDToAlSshLusuosGpKIDGtGLTFKVSTLPDVSRFKNARFLFERIPGQPLFYsSEDFI......	0	0	0	0
+12052	PF12219	End_tail_spike		Catalytic domain of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two conserved sequence motifs: VSR and YGA. This domain is the C terminal domain of the bacteriophage protein endosialidase. The endosialidase protein forms homotrimeric molecules and this domain complexes into a tail-spike stalk. The stalk region folds in a triple beta-helix that is interrupted by a small triple beta-prism domain. The tail-spike is a multifunctional protein device used by the phage to fulfill the following functions: (i) to adsorb to the bacterial polySia capsule (ii) to de-polymerise the capsule to gain access to the outer bacterial membrane, and finally (iii) to mediate tight adhesion to the membrane, a prerequisite for the initiation of the infection cycle.	25.00	25.00	26.40	113.20	24.00	22.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.86	0.71	-4.39	5	36	2009-08-03 10:56:41	2009-08-03 11:56:41	3	8	24	24	2	34	2	136.90	78	17.33	CHANGED	sDsRVSRDFsYGATPNRAIPTFMGTDGVRTVPAPLcFosplss.DlsVsHLTl+ASTSuNIRSEhhMEGEYGFIGKoVPoDsPTuQRLIlSGGEGTSSooGAQITLHGSNSSTuRRAVYNAsEHLFQuuslhPYlDNVsALGGPSNRFTTlYLGSsPIlT	.p-paVSRDFsYGATPNRTlPTFMuTsGVRTVPsPlcFoD.....DlsVpuLTl+AuTSupVRAEVphEGsYulIuKpVPoDssTuQRLIVSGGETTSSADGAMITLHGSsSSTPRRAVYNALEHLFENGDVKPYLDNVNALGGPGNRFSTVYLGSNPVVT	0	0	0	0
+12053	PF12220	U1snRNP70_N		U1 small nuclear ribonucleoprotein of 70kDa MW N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2533 (release 23.0)	Family	This domain is found in eukaryotes. This domain is about 90 amino acids in length. This domain is found associated with Pfam:PF00076. This domain is part of U1 snRNP, which is the pre-mRNA binding protein of the penta-snRNP spliceosome complex. It extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition.	21.90	21.90	21.90	22.60	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-3.66	37	328	2009-08-03 10:59:28	2009-08-03 11:59:28	3	7	272	0	222	311	0	93.50	35	26.69	CHANGED	MsptLPPsLLsLFtPRPPLpalsPh-psscc+ppst..loGlupaL..sthpchpc......p.s....ps..sEohhp++tRc+cEKppphppplpcplppasPppDs	.......MTphLPPNLLuLFsPRPPl.alPPh-+hP..c..c++pst............hsGlAsal......sph..cc.p-........................sss.......st..sEoppp+pcRc+.cEKh-ptp.pcl.cpplpp.acPppDP.................................	0	74	122	185
+12054	PF12221	HflK_N		Bacterial membrane protein N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2550 (release 23.0)	Family	This domain is found in bacteria. This domain is typically between 65 to 81 amino acids in length. This domain is found associated with Pfam:PF01145. This domain is the N terminal of the bacterial membrane protein HflK. HflK complexes with HflC to form a membrane protease which is modulated by the GTPase HflX. The N terminal domain of HflK is the membrane spanning region which anchors the protein in the bacterial membrane.	20.50	20.50	20.60	20.60	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.22	0.72	-4.21	70	1238	2009-08-03 15:45:40	2009-08-03 16:45:40	3	3	1224	0	245	716	1088	56.70	53	14.02	CHANGED	MuWN-Ps......ss.......p..pDPW....................Gp..sp..G....PPDLDElhRchpc+lsuh...FG....Gp...u	................................MAWNpPG................NNs......pcpDPWGssp..........................pss+GG+...-QG...............PPDLD-lFRKLs+KLGGh....hG..GKG.............	0	46	115	184
+12055	PF12222	PNGaseA		Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A	Assefa S, Gavin OL	lg7	PFAM-B_2578 (release 23.0)	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 558 and 775 amino acids in length. There is a conserved TGG sequence motif. PNGase A is a protein which cleaves glycopeptides.	19.70	19.70	26.80	21.00	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.53	0.70	-5.61	9	253	2009-08-03 15:52:16	2009-08-03 16:52:16	3	6	146	0	168	266	3	347.50	26	62.87	CHANGED	EsFplh.P.ssTs.......hp.hlhhstVFs.ShhpPaVs..lYhPPs....sashlhlNloV.pSpGpQaDRhAhhalssl.VFhsSTtE.ss.....Th.pDhohapsLhpts.ph.hsLuNhhscs..hTG.assslThhh..t...ssphsshhlPl.spto.shNh..uall..Psssshsp.h.lPssT.Rull.l.tpG.us.-EFWaSNl...................shREIQLYhDGlLAGVV.PaPlIaTGGls.haWRPlsuIsshsh+p..pIDlTPhLslhpcus...hplpVssLpsut......lososu..WsloGslhLals..............pus.lhuspPhhshsRhl...sh.ssGhsushpYp.suphplsh..........u.hpacpulcaSssu.hsp.shsQs.....hhptshlspphtt.s.....hpssplhash..Pl	............................................................................P.......................................sthhlhptsF....u.oh.s.p.P.hh...............hs.P..s.s............s.........s...a.....s....h...lllphps..p....spGpQaD.Rl..shla...ls......ss-lh....RoSTsEP...p.s.t..u...l..h.Wsh.KDlopY..sLh.....p...t...s..t..p..lhh.L.sNllssp........hTG.apsslohtha................................t......t................................................................t................................u.........Dhll................P...lstt.............s..........h.l.................s.tpp..h.......t...ph....lP.....p.NshRshlplhs.ssp..us..-.EF.W..Ys..Ns.................................................u...u.......saREV.lh.l.........Du....plsGshhPaPlIaT.GG..l...s.....Ph.hWcPlsulsuFsl.s.hcl-lTPaLsh.L...hD.up.......HphthpVs....s.h....................................................................Whlsutlhla.s......................t....h..........................t..h..................t...t.........h...........h.........h...t...h........................h.p..thth.....p....tt...h...................................................t.................................................................................................................................	0	42	102	147
+12056	PF12223	DUF3602		Protein of unknown function (DUF3602)	Assefa S, Gavin OL	lg7	PFAM-B_2582 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 78 and 89 amino acids in length.	20.60	20.60	21.60	20.60	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.41	0.72	-3.59	33	384	2009-08-03 16:04:58	2009-08-03 17:04:58	3	4	131	0	289	349	0	70.60	22	57.83	CHANGED	NIh..ssp......tspsssttls..pt..osshpsst......a.oTGRGGuGNht.....ssp..thsRphpDh-..h.css.cpsph..............sGRGGsGN	..................................................................t...p..ss.tsst...............a.soGRGGAGNht........t.p..st.pR.t.psh-.....p.t..t...........................hs...................................	0	77	157	240
+12058	PF12224	Amidoligase_2		Putative amidoligase enzyme	Bateman A	agb	Iyer L	Family	This family of proteins are likely to act as amidoligase enzymes [1] Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes) [1].	23.60	23.60	25.70	23.60	23.50	23.20	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.69	0.70	-4.77	53	463	2012-10-02 17:21:26	2009-08-04 10:24:11	3	7	264	0	248	457	70	231.20	19	63.15	CHANGED	pppphGlElE.hs.......GlshppsuphlsphhGs.psppt..............................thtthpl...................tssph............spaclhhDuSlhppppttt...................................................hshElVoPslphpp....lpplpclhctL+csGAhs.ssS..sGhHlHlsspshs...spslpshlphhhthpchlhcthplsh...R+hs.as..cshspphlcp..........hh....ssshpplhchah..tsscsps.......sth.ttphhpt.lshp.hhp.+s...TlEaRh.s.........uslcsschpthlphshtls	.................................................................................................................t...phGlElE.hh..........................................shs.tp.ph.sp..htphhss...ph.................................................................hth..............................................................................................t..ph..................................tpWplhtDu.Sltstpt.........................................................hshElVSP.hlthpp......hp.plp.pl............hp............tL....cpt.s.shs.spo..........CGhHlHl...s..........s..............s.s...............h.....s........hps..l+s.lhph...h...hhhE.sh...lhphhshs............c+...p..a.....s.......ps.hs.pt.hhpp............................h......sht..tl...p.....hhh........p....t...................h.tt......ptath...lNhpthhp.cs...........TlEaRh.s..............ushptsphpthlthshhh.........................................................................................................................	0	90	169	223
+12059	PF12225	MTHFR_C		Methylene-tetrahydrofolate reductase C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2600 (release 23.0)	Family	This family is found in bacteria and archaea, and is approximately 100 amino acids in length. There is a conserved NGPCGG sequence motif. This family is the C terminal of methylene-tetrahydrofolate reductase. This protein reduces FAD using the reducing equivalents from reduced FAD, subsequently reduces tetrahydrofolate. The C terminal of MTHFR contains the FAD binding site and is the catalytic portion of the enzyme.	20.20	20.20	24.20	23.50	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.58	0.72	-11.03	0.72	-4.49	33	210	2009-08-04 10:43:33	2009-08-04 11:43:33	3	6	173	0	95	202	48	93.30	36	30.57	CHANGED	lhsuhssh.hhusppththhhpp..CpsCGpChLspTGslCPhs.CPKuLhNGPCGGs.psG.+CEVss-.tcClWphIYcRlcphsph-p.lpplhPPt-appp	..............h...t.sphhhthppththhh.t..CpsCGpChLspTuhlCPhs.CsKsLhNGPCGGs..psG.pCEls......s.....p..tcCsW.hhac+hcthsph-t.htpl.hsshshp.h................	1	52	74	83
+12060	PF12226	Astro_capsid_p		Turkey astrovirus capsid protein	Assefa S, Gavin OL	lg7	PFAM-B_2608 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 241 and 261 amino acids in length. These proteins are capsid proteins from various astrovirus strains.	25.00	25.00	29.10	28.40	18.70	16.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.45	0.70	-5.12	3	174	2009-08-04 10:47:39	2009-08-04 11:47:39	3	3	7	4	0	161	0	208.40	83	61.93	CHANGED	YFVYDFQGcRVSTTETGVFCLuSIPAADSKSRYNNQIToPSIGYRN-SGTGTSFALDuASWWNILDVTQTGVIFGQPRLGVGVIQTMKTLKQHIKDFTEPAVKKYYPGTTNLDQpLKsRLNLAEGDPVISMGDTTGRRAALFYRTSDERFILLFSTTDDPGuQYpSLKMLsFWNWSLSDsKsAFLA+LRTVQFANLs....-SEsupCDSDDDDLSDVTSLFEQADLGDETDFK	......................YFVYNFQG-RVSTTETGVFCLAAIPAATTTSRYNNQITTPSIGYRNASGTGTSFLLDAASWWNILDVTQTGVLFGQPRLGVGVhQTMKTLKQHIKDYTEPAIQKYYPGTTNLDE..Q..LKQRLNLAEGDPVISMGDTTGRRAALFYRTSDEKYILFFSTTEDPGAQYQNLKMLYFWNWSYSDTKQQFLDHLRTVQFANLD....DSQPAPYDSDDDDLSDVTSLFEQADLGDETDFK..	0	0	0	0
+12061	PF12227	DUF3603		Protein of unknown function (DUF3603)	Assefa S, Gavin OL	lg7	PFAM-B_2609 (release 23.0)	Family	This protein is found in bacteria and eukaryotes. Proteins in this family are about 250 amino acids in length.	23.70	23.70	52.10	51.80	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.37	0.70	-5.20	9	135	2009-08-04 10:58:43	2009-08-04 11:58:43	3	1	135	0	20	77	0	214.10	77	86.22	CHANGED	LLDQVPLLKVss.LacYIEN-LS-LPppLLp-VaQKuYlRKNHERhQL-YCFVVTDGpsIlAVDTlGYpIPIRKSRLIPRQEQLVYEMlcstcs.pYphp.cphp..KEYHILSPsPphhsGLTRKERQLKQLLFMALDQL+oopNpAEIRYWhTEWsPppYspIQpMsFE-sWppLYcEs+pGWS-+H.phCEsLIKGQPFFEKLWEhEptsKVN	.LLDQVPLLKVDuTLYHYIENELLELPQKLLEDVHHKAYIRKN..HERL..QQEYCFVVTDGKG..IIAIDTIGYNVPIRKSRLIPRQE.....QMVYEMVENVQAE..KYEFQlEEhE...KEHHIL....SPSPalMNGLTRKERQLKQLLFMALDQLHTTKNTAEIRYWaTEWDPSAY..GhVQHM-FEDIWs+LY-EAKsGWS-KHEQLCERLVKGQPFFEKLWEMENEpKVN..............	0	3	12	14
+12062	PF12228	DUF3604		Protein of unknown function (DUF3604)	Assefa S, Gavin OL	lg7	PFAM-B_2610 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 621 and 693 amino acids in length.	20.40	20.40	20.80	20.60	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	592	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.00	0.70	-6.35	34	171	2012-10-03 00:45:34	2009-08-04 12:52:57	3	2	97	0	20	168	1789	367.20	26	62.25	CHANGED	ssscpsYaGDhHlHTshShDAhhhGs.phsP--AYRaA+G-sl......tps.sG....h.spLscPLDFhsVoDHA-hhGhhpthhssssth.....tpshtp.h.thhhpss.pssttshhhhsshsss.hspsht...tss.t....................htpssWpphlpsA-paNcPG...pFTshlGaEWTutss..usNLHRsVIaRsssphs.phlPFos...hpSssPccLWsahcshcppsuup.....hLAIPHNuNhSNGhMF..thsshs...GpslDtsYAcpRt+hEPlsElTQlKGsSE....sHPhLSPsDEaAsFEh..achushshssttssphh........sYsRsALpcGLplEpphGsNPYKFGhIGSTDoHTuhso.s-EsNFaGKhus.spss..ptphs............tt.............ppthph......uASGlAuVWAc-NTREAIaDAhcR+EsYAToGPRlpVRFFuGasaspsshpss-hsptuYucGVPMGusL........ssup.APsFLlhAh+D.....P.puAsLDRlQllKGWl-.ssGpspEpVYDVAh..Scspphssssph.sslGsoVDlsssoaosslGAsELpslWpDPDFcssQpAFYYlRVLElPTsRWosaDAl+hGhp...........ssPt..TIQERAaoSPIWYsP	............................................s...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...........huuGLsuVaApcpoR-ulh-Ahtp+csYAToGsRlh..lpF.............t.................................................................................................................................................................................................................................................................................................................	0	8	10	14
+12063	PF12229	PG_binding_4		Putative peptidoglycan binding domain	Bateman A	agb	Bateman A	Domain	This domain is found associated with the L,D-transpeptidase domain Pfam:PF03734.  The structure of this domain has been solved and shows a mixed alpha-beta fold composed of nine beta strands and four alpha helices. This domain is usually found to be duplicated. Therefore, it seems likely that this domain acts to bind the two unlinked peptidoglycan chains and bring them into close association so they can be cross linked by the transpeptidase domain (Bateman A pers. observation).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.30	0.71	-3.85	117	1823	2009-08-04 15:04:53	2009-08-04 16:04:53	3	16	849	4	342	1540	49	115.10	15	32.20	CHANGED	hshsspcls.hph.shsphlppshshstssshh.phhtphht.........phs....hplshccpt....lpphlspl......spphsptsp..sAphph......ssss...hsls.s.pphG....hpl.ctcph...hpplhpslpss.ppshp	...........................................................................................t.pp.lt..hth..phpphlpt.hhsh..pht.t.ph.h....phhtp...phtt..............phs.........hphshDp.pt....l.p.sh.ls.pl......spph.sstsp...suphph......ss.ss......hslt..s...tp....G....hpl.Dtcph.tptlhpslpst.pt.................................	0	165	288	322
+12064	PF12230	PRP21_like_P		Pre-mRNA splicing factor PRP21 like protein	Assefa S, Gavin OL	lg7	PFAM-B_2642 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with Pfam:PF01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.	24.50	24.50	24.60	25.90	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.53	0.70	-4.85	16	364	2009-08-04 15:43:10	2009-08-04 16:43:10	3	14	282	1	262	366	5	219.60	28	38.44	CHANGED	spshppplcpt..ps.....lLccshpRu-atcpp+ppcpcpc-tpEcc+hpaAuIDWpDFslVtTl-Fsct-.ht-LP.P.lshspLhttoLpp+ppshp..tpss......................pstpcccs-psspsssss..........pthphtsuspuplKlpcshpspspp.ts...........hhhCPIoGchIPtschspHh+l.LlDP+...a+cQ+cph.t+ppp...ophssspVhpNlKpluc+	...................................................................h......plppp..ps.hp...lL-psh.Rs-Wt+apcpp+p+c--ctEpE+ltaAp..IDWHDFVVVET.lcFp.........s-...psphPs...........P.ho..p..-l.ttt.L...p....ct.......h........t....t..tptht.....t.......t............................................................................p..p.pt..c..ct.tpspt.t..................................t..h...s..s..s....s....t...s.th......hlpcsYssptpp.h..............ss.thhlsPlsuppIPhschpcHMRItLlDP+...WhEQ+c+....tch.tp....s.hss.-ltpsL+pLAp......................................................	0	89	148	218
+12065	PF12231	Rif1_N		Rap1-interacting factor 1 N terminal	Assefa S, Gavin OL, Eberhardt R	lg7	PFAM-B_2647 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.	23.00	23.00	25.60	23.50	19.20	20.50	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.00	0.70	-5.49	34	226	2009-08-04 15:44:22	2009-08-04 16:44:22	3	4	185	0	157	234	1	323.80	22	19.96	CHANGED	QLAGsscsS+lDAYhp..LhsuLpuhsslPsptsltpKhsLhspaIpRDls............tp.spus..-spLsppALpLLshhlapspIuuplssDFsh.....Fll-+slsshpssshPKslspchhpllupQsFss+lhTssRls+llssLcsIspp.lpGpullhpRLsIYp+LlpQstphMhscus.Whs......pllsshLpshK-lRpp.AlsLuhphuhslG.....................pppplu+slh-lhspslpsp...phhp.htp+LppMhss..cs...ushVPpIWulllLLL..Rsth..lcpWpahppWlhllQtCFNss-...sKhpAhhAWs+hla.....shpssppsspchlphLhpPl.hsQLc++pssc.t....phpphslsuhtsLL..YYuF+Pss..s.phLDhhWsphl	...........................................................................................................hcsa.....h.t.hhph..pt.......tl...pphshhhphhpp..clt..................s........s.pLsptALphlshhlhpsplsstlspp.h...................l.pslp...sh..ts......sKslhpthhhl.....luh.........QpFs....sc........lh..s.pt..h.....sp..h.lhshhh.h.pp...hputsl.hptlt...............lhh.......pLlpph.t...Mhpp...ss...hWht............................llshhl.p....s..spclp.p.....A.....hslt....hth.s.h.hlt...............................ppt.l..uphh.t.phhspt..h......sp............lpphhts..ps...tshs.plWshhlhLL...tpph.........hcshsahsphLpl..phsFps.s...ss..h+t.AhhuWctll......................shp.....s.h..s..s....t..chlch.LhpPl...p.lcpct.s.h.t....phh.hllh.....pltshl.....h..sF...c...ss...s....t.h..................................................................................................	0	31	70	124
+12066	PF12232	Myf5		Myogenic determination factor 5	Assefa S	lg7	PFAM-B_2654 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00010, Pfam:PF01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.	21.70	21.70	21.70	21.70	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.87	0.72	-3.37	28	259	2009-08-04 15:48:27	2009-08-04 16:48:27	3	5	107	0	76	227	0	63.60	47	25.66	CHANGED	.paYuus.....S-uoSPp.SsCSDGMsDhsu.P.shopcpssa..sus.Yhspsss.sspssKsssl.SSLDCLSSIV-RI	..............................paYShs.....S-soSPp...SNCSD.G.Mh..........-hsu...P.shspcpssa......cus.Yhspsss...s....tss.+sssl..SSLDCLSSIV-RI..............	0	9	13	35
+12067	PF12233	p12I		Human adult T cell leukemia/lymphoma virus protein	Assefa S, Gavin OL	lg7	PFAM-B_2655 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are approximately 100 amino acids in length. p12I binds to the immature beta and gamma-c chains of the interleukin-2 receptor retarding their translocation to the plasma membrane. p12I forms dimers which bind to these chains.	25.00	25.00	138.40	138.20	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.66	0.72	-3.72	2	51	2009-12-01 16:56:24	2009-08-05 16:42:23	3	1	3	0	0	51	0	97.90	96	100.00	CHANGED	MLFRLLSPLSPLALTALLLFLLSPGDVSuLLLR.PPAPCLLLFLPFQILSNLLFLLFLPLFFsLPLLLSPSLPITMRFPARWRFLPW+APsQPAAAFLF	MLFRLLSPLSPLALTALLLFLLsPGDVSGLLLRPPPAPCLLLFLPFQILSNLLFLLFLPLFFSLPLLLSPSLPITMRFPARWRFLPWRAPSQPAAAFLF	0	0	0	0
+12068	PF12234	Rav1p_C		RAVE protein 1 C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2692 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.	20.80	20.80	20.90	20.80	17.50	20.30	hmmbuild  -o /dev/null HMM SEED	631	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.08	0.70	-6.36	13	405	2009-08-05 15:44:38	2009-08-05 16:44:38	3	26	270	0	281	395	1	467.30	29	21.95	CHANGED	Ghl+oac.Ahl.....sscppclcWhhs.pplpTGIpNsoLhoGSS.hsKsulV...Dps+ppLTIWDs+puh....LEYcccF......c-pIpDLDWTSTscsQSIlulGFsp+VlLhoQLR.....YDYsNpsPoahsI+clsIpshTsHsIGDSsWhssGslVVuoGNQLFlhD+pl-........spsolsophhhss......DLhclsShLNGPL.PVYHPQFLhQslluGKlsLV+cILLpLappL+hhp..ps.hc-l-SsLsls.pcFh...pss..htth.........................sc.hpshscsluusLsEpLo.chsLPhLopHpQhpLhsllEsVspVpKpccshD.NuhRFlLsh+.....ah.++sp....psSlohR-lsWAhHScsp-ILhshlspphp..h.WpcAREstlhhWhp-.ssLhspFEs.lA+tEaoKs-c+DPscCulaYLAL+KKpVLpuLWRhAshH.EQsphh+FLuNsF.sEsRW+TAALKNAaALLSK+RYhhAAuFFLLADsL+DAVNVlhpQLcDlsLAIAVsRVYEGD.sGPlLtElLcpclLPpAhp-usRWhsSasaWhL+++-hAlRALloshhsLhpspshssp..s....hsKSFLs-DPALllLYppLRpKsLpplpGu...cVss+hEa-hlL+suclYsRMGCDhLALsL	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................th..................................................................................................................................................t....t.hh.s......ph.s.t.lpt.Lh..p..tLP.LophpQh.Lhslh....-sltt.h..........p............p....p...........p...........c.........o.....lD-sGh..R.al.....Lsh+...................ah........hhpsp.....................h.p..p..s.....l..shp.....c.....hsWAhHSp..u.p.-.L.......ls.hl.st.tcs.............p.pWpp.hRthGlsaWlcs..ps.L..................Rpph......Ep...lA+....st...ap.....c..........................t....p....DP..l.D.s........ulaYLA.h+.K.K.sllhGLaR................spcp...p+htpF.h.u.psF....s-sRWRpA.ALK.NAauLLuKpRFc...................huAAFFLLA..s..s..L+DAl........pVCl..pplpDlQLAlsIuRl..YE...................u......-......s.................u.......s.......s...h..p...........p...lLppc.lL........s.......................s.............p............p...................s...........s...........ahtShsaWhlpchs.A..lcsLlp......p.........p.......................................................................................................................................................................................................	0	95	142	225
+12069	PF12235	FXR1P_C		Fragile X-related 1 protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2701 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 126 and 160 amino acids in length. The family is found in association with Pfam:PF05641, Pfam:PF00013. This family is the C terminal region of the fragile X related 1 protein FXR1P. FXR1P contains two KH domains and a RGG box that are characteristic motifs in RNA-binding proteins as well as nuclear localization and export signals. FXR1P is thought to regulate mRNA transport and translation.	26.60	26.60	28.30	27.70	23.80	26.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.45	0.71	-4.11	9	307	2009-08-05 15:45:56	2009-08-05 16:45:56	3	10	42	1	87	266	0	115.40	58	24.25	CHANGED	VEQLRLERLQIDEQLRQIGhG.RssssRs......-+E+GYhoD-u....ssol+soR....sYssRGRGRRGsshsp...GTNSEhSNsSETES-++cE.Sshuluup-.-..Rps..ptt.stRR..tGtGRG..uGRGR.Gss+ssssohuSshcs.DsNPY.SLhcssEss	...........V-QLRhERLQIDEQLRQI.G.u.....ps.st.........tptth...-ts........p.u.oR....sYts.R.G+GR...RGss..hs.o..........................GTNS-..hSNsSETES-++-ElSDhSlusp-.-....R-....s....h.pRs.stRR.....GGtGRu...uuRGR.....G...s.+sspsp...Shhcs.spNPh.uhhcss-s.p....................	0	6	12	33
+12070	PF12236	Head-tail_con		Bacteriophage head to tail connecting protein	Assefa S, Gavin OL	lg7	PFAM-B_2709 (release 23.0)	Family	This family of head-tail connector proteins is found in bacteria and viruses. Proteins in this family are typically between 516 and 555 amino acids in length.  This protein is found in Phage T7 and T3 among others.	19.90	19.90	20.20	20.70	17.70	19.80	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.11	0.70	-6.12	28	301	2009-09-11 16:20:59	2009-08-05 16:50:28	3	2	253	0	33	273	923	417.40	20	87.51	CHANGED	appl+scRpsacs+hc-hucaslPthhshtss......ptsppphpphapususculpsLAupLhtulhPsspsWF+Lslss......pt.spttsplcthLsplp+h...hhphhps..ssahssltpshpcLlssGsuhlhhtp......p..shsthpshslspaslpcDs.pGs.l-hlh+.......t..pchuh..cslspplppthpst........cspcplclhptlh.c..............spsh.asshh.spstts..hlpcushcphPalssRapchsGE....sYGcu..st-hLsDl+sLpplpcthlcutphsspshhllsssuhhpstsltsuutshh.stsstsshshhsl.pptsc.hssuttslpslcpRlppuahhs.h.......psupchTApElphpspEhtphLGslhuthspEhlpPllpRshthht..+suh...lPs.....hPp...th.......lcsshhosLstht+tt.shsulpphhshlutluthtsslhstlshsphhctlusthGhs.ssllpoppp	.................................................................................................................................................................tthcstR.psacsphpchtchhhPphh.h.pt.......................tppp...pphhpssustuhp.Luutlhtslhs.sp.ahclph.p...............p..tt..lc.hlptlpph...h.phhpp.....sshh.th.phhhplhshGsuhh.hl.p..........t.th.thp.hslsphhltpss.pu.p.lshlh+..........pc.hsh..stlscphp.pthpp..........................p.pcpl...cl.hphlh.p.................tpshsatshh.......tshp........hhpp.sshpthPhhssRa.hhss-....sYGpu..s.phlsshctLp.hppthhphhthshp.s.hh.sssshhhp...tsltsushshh...s........s....ttt...thh.h..........ss.hsssht.hpphcpplppshhhs.h.........tsspphTApElh.htpEhtthLGshhphhpp-hhtPllpphhthh...cts.............ls........Pp.......h..............h...c.ph.oshstht+t..thssltphh....th...h...utl..hth...s.p..h.h.s..tlshsthhpthsth.Ghs..thhhs.t................................................................................................	0	12	23	30
+12071	PF12237	PCIF1_WW		Phosphorylated CTD interacting factor 1 WW domain	Assefa S, Gavin OL	lg7	PFAM-B_2805 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.	25.00	25.00	25.20	25.20	23.90	24.20	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.32	0.71	-4.98	14	172	2009-08-05 15:54:26	2009-08-05 16:54:26	3	8	108	0	110	164	19	167.70	39	24.91	CHANGED	KLcpLYcps.......s.c..stc.phFhtplaslLhRY.pshh....st...usGhQuALstsVF-sL+ppasVohECFASPLNsha.....tpaCSAF.......sDsDtaFGShGsFhs..apPspG....SFEsNPPFscElhsthsp+htplL...........ss.uppsLSFlVllP.tWtpssh..hpphppStappps.hllsutpHtYhcG	........................................................t.....stt.chF.h.+lasLLhRY...pshh........Gs...t.............t...upuhQuulPspVF-sL+ctFs.........Vs..hECFASPLN..saa...........................ppYCSAF.......sDTDsaFGShGs...hh-......FpPhuG....................SFEsNP...........PFscELhcthssHh.c.cLL.................ts.ospPLSFl..VhlP.pWcps.s...........hpphcpShapRpp....hll.shp.HtYhpG.......................................................................................	1	49	62	89
+12072	PF12238	MSA-2c		Merozoite surface antigen 2c	Assefa S, Gavin OL	lg7	PFAM-B_2755 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species.	20.60	20.60	56.90	20.60	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.41	0.71	-4.65	14	159	2009-08-05 15:54:32	2009-08-05 16:54:32	3	2	1	0	4	148	0	182.00	36	75.26	CHANGED	VsMPSDsSpDALsAhh-ILcslK-clPFcTSLFDptVLpsL-hQ-sDplFcSLl.RVsLIKphLotFNuFLN..DNPt+hLssppsEMTKYYKKHIsscDspVKDYshLVKFCNDFLDSESPFM+hYKthNpY-EL...VcKtPupssSPs.SSsQusoss.pPupsssu.soossstsus.s.............psscPAcospss.............uuSFTFGGLTVA	.....................................VsM.ussupcshcALhtlhtllKpcsPFpTS.FDs.slc.hshQss--lFKhLl-ulhhhchhlpchNuFls...pssch.sphcschpcYYhcpIhscpup...h.shstLsphhpsFlsspushhhh..........cth.........ppa..........-...........s+.Kt.tps..p.h.sSspspsps....pPupspso............................................AspPs+PApospss.................GSSFTaGGLTVA.......................................................	1	4	4	4
+12073	PF12239	DUF3605		Protein of unknown function (DUF3605)	Assefa S, Gavin OL	lg7	PFAM-B_2795 (release 23.0)	Family	This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 161 and 256 amino acids in length.	23.30	23.30	23.60	23.90	21.80	23.20	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.13	0.71	-4.39	21	242	2009-08-05 15:54:41	2009-08-05 16:54:41	3	9	139	0	185	240	3	143.70	31	61.71	CHANGED	hsWppl+cIlpsNcL-hhpR.PStLc+YlcapccltupY.GSlhcallpc+Lt..W.s.sp.cth........tstPFt.spDh+lLhNDaPYulE.slsHLVVWoKhtL..sDsso..sDlsscuRpcI-cFVccsFhp+h........ss-pVlWF+NWpuLpSV+ulEHh.HVhlhp	.................................sWpplppllt....p..sp...LphhpRtssphc+Y.ht.aptplctp.a.uolhpalltp+Lt..W.t..s..t......................................shs.F.tp....s......sD...h+lLhNDWPYul..p.sl.sHlVVWoKh.l....s.c.ts................scho.psRt.lppalpcp.Fht+h...............stpplhWF+NahsLpSV+ulpHhHVhlhs..............................	0	53	101	154
+12074	PF12240	Angiomotin_C		Angiomotin C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2808 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin [1]. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically [2].	23.20	23.20	23.30	24.20	22.50	23.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.51	0.71	-4.82	8	207	2009-08-05 15:55:09	2009-08-05 16:55:09	3	5	58	0	103	167	2	196.00	58	24.48	CHANGED	YVEKVERLQpALsQLQAACEKREQLEhRLRTRLEpELcSLRsQQ+Qupssuuosus.....hssssLpEpLREKEERILALEADhT+WEQKYLEESsMRpFAMDAAATAAAQRDTT..IIsHSPssSh.soSh.......pEElhsAN+RsQEMEsRIKsLaAQIlEKDAhIKVLQQRSR+-suKs-psS............LRPA+SlsSI.su...tsoshpu+spoLoss	.....................YVEKVE+LQQALsQLQAACEKREQLEhRLRTRLEpELcuLRhQ.Q......R......Q...u........sst.ss..s.ssp................hsAssLhEh.LREKEE+ILALEADMTKWEQKY.LEEssMRpFAhDAA...........ATsAAQ.R..DTT.....lIsHSsssSh..soSh...........pEEllhAs+Rpt-MEsR...IKsLHAQIlEKDAMIKVLQQRS.....RK-s.uKss..psS............hRPA+Sl.SItsA.....ssGh.uhpoo.p..s.............................	0	15	25	53
+12075	PF12241	Enoyl_reductase		Trans-2-enoyl-CoA reductase catalytic region	Vella Briffa B, Coggill P	pcc	Pfam-B_10602 (release 10.0)	Family	This family of trans-2-enoyl-CoA reductases, EC:1.3.1.44, carries the the catalytic sites of the enzyme, characterised by the conserved sequence motifs: YNThhhFxK, and YShAPxR. In Euglena where the enzyme has been characterised it catalyses the reduction of enoyl-CoA to acyl-CoA in an unusual fatty acid pathway in mitochondria. the whole path performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation.	30.10	30.10	30.30	31.70	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.32	0.70	-5.38	49	655	2012-10-10 17:06:42	2009-08-06 14:20:28	3	4	531	5	162	543	120	236.20	56	59.63	CHANGED	++sGoAGWYNssAFcctAcptGLaA+SlNGDAFSsEhKppsI-hIKp-h.Gp.lDLVlYSLAoPhRpcPc....TGclapSsLKPIGpsaospslD.hccc...plt-sol-PAo--EItsTlpVMGGEDWphWlcALpcAsVLA-Gs+TlAYSYIGs-lTaPIYhcGTlGcAKcDL-psAtslspcLus.hsGpAaVoVhKAlVTQASuAIPlhPLYluhLaKVMK-cGhHEGCIEQhpRLFpcpLY	......t.KsGTAGWYNsAAFc+hAcptGLYA+SlNGDAFSsEhKppsI...-hIKp.....DL...G...p.VDLVVYSLA....SPhRpp.Pc.........TGEla+SsLKPIGcs......h.oupulD..Ts+-....slhEsolEPA........T.-p.EIpsTVsVMGGEDWchWI-ALtcAGVLA-GsKTlAaSYIGs-lTaPIYacGolG+AKhDLDpsupuLsp+Lus.hG....GsAhVuVLKAVVTQASS..AIPsMPLYluhLFKVMKEcGsHEGCIEQl.RLFp-+LY...............	0	43	84	122
+12076	PF12242	Eno-Rase_NADH_b		NAD(P)H binding domain of trans-2-enoyl-CoA reductase	Vella Briffa B, Coggill P	pcc	Pfam-B_10602 (release 10.0)	Family	This family carries the region of the enzyme trans-2-enoyl-CoA reductase, EC:1.3.1.44, which binds NAD(P)H. The activity of the enzyme was characterised in Euglena where an unusual fatty acid synthesis path-way in the mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The binding site is conserved as GA/CSpGYG, where p is any polar residue [1].	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.64	0.72	-4.19	44	648	2012-10-10 17:06:42	2009-08-06 14:30:23	3	3	537	5	165	901	265	78.60	60	19.95	CHANGED	lIcP+l+GhICposHPhGCptsVppQIsYl+s...pstl.sG...PK+.......VLVlGASoGaGLASRIssAF.GssAsTlGVhFE+sso.-	.....................................IIKP+lRGFICsTsHPsGCEtsVccQIsYlKs..........pGsI..tsG............PK+...............VLVlGASoGYGLAuRIuAAF.GuGAsTlGVFFE+suo.........................	0	43	86	123
+12077	PF12243	CTK3		CTD kinase subunit gamma CTK3	Wood V, Coggill P	pcc	Pfam-B_12814 (release 23.0)	Domain	The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation [1]. The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2 [2].	33.70	33.70	33.70	33.70	33.50	33.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.55	0.71	-4.54	9	129	2009-08-07 14:05:10	2009-08-07 15:05:10	3	5	116	0	105	123	0	134.20	37	32.69	CHANGED	hDPFEVRhpFoshLp+LsAShpShpKAApaALKa.pDh-EDLasCILEpLEcs..shNsRsNIhaFl-p.hsE.shpps......pssYlchlpRDlh+lVDsVsPcsssst.ANlpsVR+lLpslpp+phls.pplp-l..........tsLcsRc	........hDPFEVRhpFos.Lp.+LsAShpShQKAApaALKa..+-hsEDLasCILEpLE+s..................shNs..RsNIhYFI-p.lh-huppps.......................p.sYlchl....pRDlh+lV.-uVsPsssu........u...h....sNl+ps++.....VLpslps+phLss.phlpcl..........t.lpt+..............................	0	32	62	90
+12078	PF12244	DUF3606		Protein of unknown function (DUF3606)	Assefa S, Gavin OL	lg7	PFAM-B_2813 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 85 amino acids in length. There is a single completely conserved residue G that may be functionally important.	20.80	20.80	21.30	23.80	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.19	0.72	-4.34	28	202	2009-08-07 15:46:44	2009-08-07 16:46:44	3	2	117	0	106	199	9	55.80	27	86.33	CHANGED	sssps+tsstDpsplsls-phElpYWs+chslopspLcpAVcpVGssspsVcpcLsp	..................tpppttstD+splshs-paElpYWs+chslotppLcpAVcpVGss.sppVctaLt...........	1	18	48	69
+12079	PF12245	Big_3_2	DUF3607;	Bacterial Ig-like domain (group 3)	Assefa S, Gavin OL	lg7	PFAM-B_2816 (release 23.0)	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	27.00	5.00	27.00	5.00	26.90	4.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-8.71	0.72	-4.41	11	1694	2012-10-03 16:25:20	2009-08-07 16:47:49	3	301	461	0	392	7792	931	42.20	24	4.75	CHANGED	sustps.....tpsstSshhPsushc-.aolpFhlhDpAGNpsphshpphhhDshhss.....Pstsas	............................t................................................................t..........a.....p....lp.....h..h..s..sDpAGN....p........s.s..p...t.h...t.h.h.h.cs................h........................	0	165	256	330
+12080	PF12246	MKT1_C		Temperature dependent protein affecting M2 dsRNA replication	Assefa S, Gavin OL	lg7	PFAM-B_2862 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.	19.40	19.40	20.60	20.40	18.50	16.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.29	0.70	-5.37	24	169	2009-08-07 15:47:53	2009-08-07 16:47:53	3	8	150	0	118	167	0	233.90	25	31.59	CHANGED	RhLpLhGals..........cppphTtaGcsLtpsssh.............htEshllhlELlRhslLssp..............s....sshpss..sc-pphlhLlSRlholhplpppshsYpGPls+plLsF+shlphl+pslppLlEsllsshlhpGcssp......stsphtplstpLPFhhss.ssshGlhschaLpchhpptpsppps.p...h.hst.......................a.pssslpc-LspuhpFWcslhpsspplsppphhsts..........hphascAscalppth	...........RhLpLhG..als..........pppphTtaGpsL.pshp...stp..........hpEshhlhlELlRhslLssc.................................s....tss.hpss....s--pp.hlLlSRlholhpl........pp.....c......s.....hsYs.GPls+pLLsF+shlphlppsLRpLhEs..llsuhllsGcssR............................spschtplshp..LP.Fhtss.ssshGlhs+haLpch.p..p.tpsp..s.pt..ph..hh.tsp...........................a.ps..shppsl.chuhpFac.tlhpshpplsppth.stp...........t.appAspahpt...................................	0	42	69	102
+12081	PF12247	MKT1_N		Temperature dependent protein affecting M2 dsRNA replication	Assefa S, Gavin OL	lg7	PFAM-B_2862 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the N terminal region of MKT1.	19.40	19.40	30.80	29.30	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.99	0.72	-3.66	25	157	2009-08-07 15:51:14	2009-08-07 16:51:14	3	9	139	\N	111	153	0	88.80	33	11.26	CHANGED	PsDhH-llGp+LPtElYaYhStGLlusplhsslopG.lh-psP..Lsst.....ocpYR+Llt.cplt.l....+spslsLlsppL...s+haphKpIpshhWF	..PsDlH-llGp+LPpElYaYhSpGLlusclhsslosGplh..p...P.............Lsst....tSppYR+Llt.cslh.h....+spslsLLsp.L...pRaaphKpIphhhWa.................	1	36	64	96
+12082	PF12248	Methyltransf_FA		Farnesoic acid 0-methyl transferase	Assefa S, Gavin OL	lg7	PFAM-B_2872 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 110 amino acids in length.Farnesoic acid O-methyl transferase (FAMeT) is the enzyme that catalyses the formation of methyl farnesoate (MF) from farnesoic acid (FA) in the biosynthetic pathway of juvenile hormone (JH).	21.40	21.40	21.70	21.50	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.15	0.72	-4.00	23	286	2009-08-07 15:52:06	2009-08-07 16:52:06	3	50	107	0	180	312	1	98.80	28	18.05	CHANGED	HltLoss.......hPh-ss.hhEIVlGuapNTtSsIRppht........ssslscspoPslL.sshc.phahlp.apsGplpVsps...G.cstPFlpap..Dsp.....thslpYhuF.osWssssha	....................ltLoss........sp-..ssshhElhlGGapNspSsIRpsp..................................spslsp.s.pTssl.l.s.spEh+pFWIs..hpsGhlpVGps.....u...c..t.pshhpap..-sp.....shsl.pahGh.ouWss.s...............................................................	0	77	104	162
+12083	PF12249	AftA_C		Arabinofuranosyltransferase A C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2900 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 179 and 190 amino acids in length. This family is the C terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The C terminal region is predicted to be directed towards the periplasm.	25.00	25.00	86.80	86.20	19.80	18.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.08	0.71	-4.85	9	161	2009-08-07 15:52:31	2009-08-07 16:52:31	3	2	159	0	34	126	0	178.10	55	27.40	CHANGED	sIPcsLcssIslAYTD..TDGpGpRAD+cPPuAspYYsplDcslpcpTG+sRscTVVLTsDhoFLSaYPYaGFQuhTSHYANPLA-FspRAstI-.....sWSpLpssschlAALcpsP....WpsPssFlhRpuu....ps.....uaTlcLApDlYPNpPNVRcYsVpFssulF..-sPtFslpplGPFVls.sRp	.....................DIP-hLps-lslAYTD..TDG.GpRuDRRPPGuppYYspIDtsIpchT.G.+.tccTVVLTADauFLSYYPYaGFQuLTSHYANPLApF-cRAspI-.....SW.....up...L...p...os--FltALDphP....WpsPsVFlhRtuu....ps......................uYoLRLApDVYPNpPNVRRYsVphssslF..sDP+.FsVpp..lGPFVlslRp.......	0	6	22	31
+12084	PF12250	AftA_N		Arabinofuranosyltransferase N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2900 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 430 and 441 amino acids in length. This family is the N terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The N terminal region has been predicted to span 11 transmembrane regions.	22.80	22.80	116.60	36.00	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.58	0.70	-5.76	5	168	2009-08-07 15:53:10	2009-08-07 16:53:10	3	3	160	0	37	136	0	421.50	50	67.31	CHANGED	LGQMllulVVAulVAsVuLhAIARVEWPAFNSSNQLHALTTVGQVuCLAGLsuuGLLWR+..G....R.R...plARLGohshlSAFoVVTLGMPLGATKLYLFGISVDQQFRTEYLTRLTDTAGLRDMTYIGLPPFYPAGWFWLGGRlAALTGTPAWEMFKPWAIlSIAIAlsVALVLWusMI.RFEYALVVolATTAlsLAYuSsEPYAAlITVLlPPsLVLAWuGLuu....pcpGGWAAVVGsGlFLGlAAoFYTLLlAYAAFTlslMALLlAuu.......hRRuaDPLlRLlVIAVlSGAIALlTWuPYLLtAhRGsPA-SGTAQHYLPc-GAcLsFPMlpFSLlGALChLGTlWLVsRARoSsRAGALAVGVlAVYLWSLLSMLsTLuGTTLLSFRLQPTLTVLLuAAGAFGFVEssts.....lutRhps..uRRVlusAsAVGAlGAl	.....................................htlssAlllAssVulVuhhAlspVpWPAFsoSN.h+ALTTVGQlssL..sslsuhshlW++..s..............................R..R......hLspl.suhlhsuu...hsVsTLGhPLuATKLYLaGISVDQpFRTpYLTRLTDosuLpDMoYlsLPPFYPsGWFWlGGRhAsLhGhPuWEhFKPWAIhSlAlAsslulsLWtRhl.phchAhhlslATs.AlsLsauusEPYAA.lIs.lh...lPPhLV....LshpuLpu............................ttuWuAllGsGlFLGhuAoaYTLhsAhsAholllhAlllAuh.......................hct..u..h..cP.L........h.....RLsVlGsluhAIAhhsWhPYLltshps.s.susouoApHYLPs-GAtLshPMlphSllGslCLlGhlWLVhRu+sss.AsALulGVlulYLWsLLSMlsTLutTTLLuFRLpPsLolLLssAGshGhsEhsts.......hstp.......uR...t..lh.shsusl.uhhGul...............................	0	6	23	34
+12085	PF12251	zf-SNAP50_C		snRNA-activating protein of 50kDa MW C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2919 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 196 and 207 amino acids in length. There is a conserved CEH sequence motif. SNAP50 is part of the snRNA-activating protein complex which activates RNA polymerases II and III. There is a cysteine-histidine cluster which contains two possible zinc finger motifs.	23.30	23.30	23.30	25.70	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.89	0.71	-11.46	0.71	-4.93	20	210	2009-08-07 15:54:04	2009-08-07 16:54:04	3	7	163	0	144	212	4	183.30	30	46.58	CHANGED	tpcahlLuoQsLs-L+DshhChsstph.h..............spsphpuuaFFIcGsFYsDhR.....sscshDhSpsIhpa......sppps.............shuc.hpstpM-csphsDLplplGpPhhahHQGsCEHhllhoslRllsptc...shccstYPhhshcsphppptC.hC+httAphllhs.sphtscsPuahCssCFcha+asssGccls......pFpsatYhcc	...............................................................................h.tphhlLusQpLs-L+Dtl.C.s-h.h................................................................hstphhpSuaFalcssF..Y..sDhR................spshDhSpsIhcW......tpppp............................................thsp..hp.....st..pMcps..pasDL.p.l+l..G...P..YlYhHQ.............GsCEHhllhsDl..R...h.......hp.pc.............s.s........pt.YPhhh..h.p.........h.t.tppC.lCphh.A...phls.s.cphtspsPsahCc.Cachh+hs.tpGphlh......pa.sh.h....................................................................	0	62	85	120
+12086	PF12252	SidE		Dot/Icm substrate protein	Assefa S, Gavin OL	lg7	PFAM-B_2926 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 397 and 1543 amino acids in length. This family is the SidE protein in the Dot/Icm pathway of Legionella pneumophila bacteria. There is little literature describing the family.	18.50	18.50	18.50	18.50	18.40	18.20	hmmbuild  -o /dev/null HMM SEED	1439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.27	0.69	-14.42	0.69	-7.26	7	111	2009-08-07 15:56:26	2009-08-07 16:56:26	3	4	15	0	19	89	0	795.40	33	87.88	CHANGED	MPKYVEGVELTQEGMHAIFsRMGHusIoSGoIYNG.PTIDptALspQGFMPVLTGVGP+pDSGHWIMLIKGPGNQYYLFDPLGKoSGEGYQNILAsQLPhGSTLSVIPNsssLNhGLCGYWVASVGLRA+AtLNpcsPPsLhNLGQTITsEMRNELscDGYcKITsWLRAVuDEFP...cGDsQP.DAKALREsTEKs.L+I-IPs.V.PsKDpoPKElslcPTsPQ.s.VPsWNGFSLaTD-sV+sAApYAYDNYLGKPYTGsVEusPAshGGph........h..RQpHGLAHTLRTMAYAElIVEEARKAKLRGETLtKFKDGRTlADVTPEELKKIMIAQAFFVsGRDDEtSstcp......YtKYHEQSRDAFLKYVcDNcSsLIPDlFKDpc-VsFYApVIEDKsHDWsuoPAHVLINQGHMVDLVRVKQPPESaLEpYFsohpsWIGopAsEAVFuhQRQFFHATaEVVsGF......DS-NpEPHLVVsGLtRYVIGEDGpPIREt.cpupK..cG-LKsFsQsYKLK-NERFMRVDEaLKLPEVQpTFPGuGK+LEGGhPGhs.hsYapRLNShpRARCENDVsFCLtQLQpAHcKsKIDPIKpAFQSSpcKsRRQPNhDEIAAApIIQQIhANPDCIHDDHVLINGQKLEEpFFRDLLAKC-MAVVGSLLNDTDItNIDTLMRHEKDTEFHSTsscAVPVK.IG-tW..cpRIpspusslT...QhKHDLIFLMQNDAWYFSRVNAIAQNRDKGSoFKEVLITsLMTPLTsKuLhDTS+u.........sPp+LaRGL.sLsEEFsptLINQANshIANTTppLFTDhSsEAFKQIKLNDhSphSuRTsASTTTshpLspphWs.....SNVIFEMLDPDGLLHPKQVGpHssGoEsEFSVYLPEDVALVPlKVThD.GKTppGcsRalFThVAVKSPDFIPRHESGYAVEPFLRMQssKLsElpsuIEK..sp.t..................PphEsIFs.LQscluh.ph.sclSstYKsFLpppVsPVLEpCLsulhpsssshLsKALAsFPoDpQWSAFN.sEAhpAKtQMDAlKQMltpKVVL-.....ALTQCQ-ALEKQNIsGAL-ALKpIPuEKEhup...IupELREQIQus+Q-....LESLQRAssTPlVoDccKV+.RY-sLIpssoK+lT-LEKupLssLDslKKuIusLsNLpQElTlLRNEKlRMHosoDK.VDFSDIEpLEpQlQ.lcTKLsDAYLlplTKplSAL-p.hPKs.o..-lKohlupFhshhs-IEhLRNERIKKHGuSKDPLDhSDLDKLpGpLQtlNQSLVssLlpsIRsSlsQMc.spTFchQcctIppNh-hLscLEKoLDcScsucK.+EDlsKLpsLLlsKQ.KAYPpMlQLQh+SEshIpQLRElCpsHaDsLsKsRpARLQEL-+...puGI...lGNlhasl...TshlGLTsDEpl-I+hKpQoLARFKs-LhNDK.DhDpLIspLAcKpPSELQEuLGISc-	.........................................................................................................................................................................................................................................................................D..VhtshpYsapphLtpsYs..Gs.....h..c.t..ss....t...t.h..........................R..HGLuHThRThhhuplhhEtu+.........tthtsGpolADlo.p-l+Kl.IAQhFFVsGR-sEtS.hs....................YtcYH..utptF.cYsccp.....sclFp.pc-lphYuthI.Dc.tp.atsostt.hLlp.uHMlDLhRsKtP.Eshlt.........h.ph...hG..ss.slhthtRthFhAThtsVs.h......ssp.........sa.s..s................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pp.p...p.Ll.th.pplh..tp.t....t..pp.h.........................................................................................................................................................................................................................................................................................................................................................................................................................	0	8	8	19
+12087	PF12253	CAF1A	CAF1B;	Chromatin assembly factor 1 subunit A	Wood V, Coggill P	pcc	manual	Family	The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A [1]. The A domain is uniquely required for the progression of S phase in mouse cells [2], independent of its ability to promote histone deposition [1] but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints [2].	21.20	20.90	21.30	20.90	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.90	0.72	-3.86	32	308	2009-08-11 15:32:32	2009-08-11 16:32:32	3	13	258	0	216	310	1	80.70	39	11.05	CHANGED	hKhlpFtEssRPPYhGTao+..........hh.h..+sPhppchsshDY-YDSDtEW.....EE..-E-G...E...-l...-.s........----.....---...-.-...p--...........-hDs..F	........................KhLpF..p.EshRPsYaG..Tas+................p...sthlhsRsPhsp.....-.......s....lDY......-hDSDtEW.....EE......-.E.G...E.....sl.c.s........--.--.....-.--......c..-....s--.......-.Ds..........................................	0	70	115	177
+12088	PF12254	DNA_pol_alpha_N		DNA polymerase alpha subunit p180 N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2966 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00136, Pfam:PF08996, Pfam:PF03104. This family is the N terminal of DNA polymerase alpha subunit p180 protein. The N terminal contains the catalytic region of the alpha subunit.	20.60	20.60	21.30	20.60	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.36	0.72	-4.16	37	311	2009-08-11 15:36:44	2009-08-11 16:36:44	3	14	261	0	202	307	3	65.20	42	4.65	CHANGED	LpcL+thRputppttsth..csc...-tp...pIYDEVDE--YcclhcpRhtp.DDFlVDD...s...G.GYsDpGt--.W-c	................................LtpL+thRputpppt.ph.........-V-......-.p...slY-EVDE-pYp+lVcpR.pp.DDFlVDD..................s...G..GYsDDGcE..a-..............	0	61	103	161
+12089	PF12255	TcdB_toxin_midC		Insecticide toxin TcdB middle/C-terminal region	Assefa S, Gavin OL	lg7	PFAM-B_3032 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 150 amino acids in length. The family is found in association with Pfam:PF03534. This family is the C-terminal-sided middle region of the bacterial insecticide toxin TcdB.	25.00	25.00	29.90	28.90	23.60	22.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.77	0.71	-4.54	22	147	2009-08-11 15:37:11	2009-08-11 16:37:11	3	14	112	0	49	132	6	142.80	38	8.34	CHANGED	hhtRALKGplLRoElYGhDso.........tptshPYoVopsRhpVR.lpstss..p..slhhshslEshoapYE.RlssDPpsspplsLpsDpaGpsLcolslsYPRRspst.........s.a....ss.hspthhss..ShD-pQptL+lstsppohpHlspsps.......hhLGLP	.....htRALKGplLRoElYGLDso.........p.sshPYoVspsRYpVR.lQssss.....p......................s...VhhshslEploYpYE......R.ls............sD.PpsspplsLpsDpYGpsL+oVsIsYPRRspss.........ssa.....s.hspthhssphDppQptl+lspppppahp..ssp.....ahLGLP................................	0	15	27	41
+12090	PF12256	TcdB_toxin_midN		Insecticide toxin TcdB middle/N-terminal region	Assefa S, Gavin OL	lg7	PFAM-B_3032 (release 23.0)	Family	This domain family is found in bacteria and archaea, and is typically between 164 and 180 amino acids in length. The family is found in association with Pfam:PF05593. This family is the N-terminal-sided middle region of the bacterial insecticide toxin TcdB. This region appears related to the FG-GAP repeat Pfam:PF01839.	24.80	24.80	24.80	25.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.20	0.71	-4.82	29	294	2012-10-05 17:30:43	2009-08-11 16:37:22	3	55	209	0	101	298	21	169.80	24	8.84	CHANGED	spsGstau..pshplshPsssphs.t.pplphADlpG.Ghsslll.ohsth..........ts...tpahhthstt......p....PhLLsslsNshGspsplpYt....oSsphhLc-ptt.t.t....ssspLPhshpllpchshpDtl....s.Gsp...hsppapYppGhaDshEREFpGFuplpppDssss...................ssh.spsaatTG	......................................................................................................hs.hht.s......phplsDlpGpGhssllh...sssp.............p.......phhhh.shsss...............................+PhLLsslssshGupsplpYc............................s.Ssph....h..hs.-p....tt.tt...........................sspLPh.s.lpllsp.......s.pp..p.Dtl...........s..Gss.........hsppapYpp.G..haDstpR.-FhGFupVpppDhsst...........................psssh.spphah.....................................................................	0	40	59	86
+12091	PF12257	DUF3608		Protein of unknown function (DUF3608)	Assefa S, Gavin OL	lg7	PFAM-B_3083 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with Pfam:PF00610.	25.00	25.00	25.30	25.30	23.20	24.10	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.71	0.70	-5.50	9	344	2009-08-11 15:40:12	2009-08-11 16:40:12	3	8	247	0	223	351	9	242.40	40	18.31	CHANGED	VElalKDs.LsRssMWshSopLlsoCVahspRlsaLsshpusVKuIY+NGKKlhSGYIs-NTKIlFRSESA+llFllQlocEMWHFEEsGEhhFHKlVNSLFPKIF++W+-hsTHHoITIVhhsSlDhos.sassLs.GER.pNpcDYFRlVVDQVslhaW-cIMtsLRhEFhphp+Dlh.pp....pDssthshcGphhPslKuNlLEsINluhTllsD.F+ssDL+HTssHlIlloPGoGLaDV-YDLLh.To+KhhSl-hulDlICLSpPPLHlVPLFRY	..................................................................VElsh+DpalsRuDMWRl.t.p.p.LsspssYhs..p+l.......a.h....s...l+.sps.......t.pla..h...p.....s.........c.+V........h........sGah.s.ppT+.lFRSpSA..hhhlFIQ.........hSpEMW-....F.........-......................G................-lhFpK...slNuFLsc.LF.........p+Wtphs.....s..p..H.lT.lVL.....F.......s........p...h.....t...........................s...................t.............................t.............h........t.........p.........l.........t.......................s...................p.........t..........p.................h........c........DFY+V.V.Vp..p.t.p..t...cW.s...s.lLhpl++.F.hpa..h.............lhh..........p.............................................................................................h......t......ups.......Ss.....u.h.....p.GNhLEAl..........Nluhs....hhsccalsRshsRTGp..l..VITPGsGlF..-V....D.hpLh....hlTpp+hl.sp.Gl.G.lDLlChuc.PLHsVPLF+a..............................	0	86	125	187
+12092	PF12258	Microcephalin		Microcephalin protein	Assefa S, Gavin OL	lg7	PFAM-B_3105 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 384 and 835 amino acids in length. Microcephalin is involved in determining the size of the brain in animals. It is a protein, which if expressed homozygously causes the organism to have the condition microcephaly. Organisms expressing the mutated form of this protein in a homozygous manner develop a condition called microcephaly - a drastically reduced brain mass and volume. Microcephalin is predicted to contain three BRCA1 C-terminal domains, the first of which is the probable microcephaly mutation site.	25.00	25.00	26.10	26.10	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.34	0.70	-5.48	6	148	2009-08-11 15:40:18	2009-08-11 16:40:18	3	5	90	0	19	138	0	368.30	56	71.39	CHANGED	ESFAuGLpSSFDDLCGtouCGsQEcKLtt.ls-hpoDsChSSPVLKsuSlaSSAussaLsQLoPQKssusLSKpElstQRDsAGclVTPDpKQutGlupEshDEKasLSPThSuoKs+.hsHSps+uSSAKRKRsu-hSpSuPcE+LK.KRspt+ushPplQLaKS-spLppsstsAscu.usttSSYDDYFSPDNLKERsSEsL.PtsQ.suuPAtFpC.RuLSKpERpsIL-MuDFSClGK+sRols.loslhAKosSSLpKPupscusAshuClhS.tTuAs--oPGsCsQAGs.tt-DspPtGsutspTh-s.Ahs.....cG.cGDloPLcGuSpEh+EssDs+STQKEGssscspsSutGEsQs-sc.uFusDsss-pSsp-KEslupGhSt	....-.FAGsLHSSFDDLCGsSGCGsQERKLGG.ls-hKSDsChSShVLKsssl+sSsS.saLsp.oPQKhhusLSKEElshQR.shAGclVTPDpKQAtshSptsF-EKhpLSPThSuTK.s+hhh+S.p...PpSSSsK......RKRVStsSpS.PPKE+hK+KRSlR+shhPRLQLh+SEsuhppsuusA.lEsLusGESSYDDYFSPDNLKERs...SEsL.Pt.sQ.Po.uPA.hpC.R.SLSK+ERTSlhEMuDFSClG+psRol-.hTs.hTAKohsS..QKsuN..scucsshSsVTSccTsAsE-o.tsCtQAsspt+-DA.pP.tGssh.saTl-s.sh.............KGpcGDhTP.LcGS.cE....h....KEhlslKST.....Q.p.c.GTs.SKhsNSuEGE.....AQS-cc...sFlsDsshEpSsE.E+EsLPtG.........................	0	1	1	4
+12093	PF12259	DUF3609		Protein of unknown function (DUF3609)	Assefa S, Gavin OL	lg7	PFAM-B_3173 (release 23.0)	Family	This domain family is found in eukaryotes and viruses, and is typically between 348 and 360 amino acids in length.	24.10	24.10	24.30	25.60	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.01	0.70	-5.78	7	125	2009-08-11 15:40:30	2009-08-11 16:40:30	3	5	70	0	28	124	0	295.00	28	53.39	CHANGED	LthLGspL+popsAIhEAlhSAaQspLSPhVLolpQLptch..h.ucLspthtL.hpp.oISDIYplAols.stQhsNalVFpIpVPLlDsEpFNlYRLTPIPR.lsNGpIQLl-TETPYLGIsDHLDRYFPLQN..LDDClcLssERalCc.spITYGssDcohsCoLAAIRNpoSpsCThRpVpcpSlWT.hlAPNSWMVALoKELoLhGVCSs-cQEL+INGSGILoIpSDClVRSssVTLQGpspKthPS+puYASLQhssposccsshh-SFspLhpIlspLchpQcp.psltsh.hshlsVCPsllLIsLLlShsWhY+saRp+t.....sQpPh..Vssh.sspNcspTsshPLLEKpEl	.................................................................................lpcAl..sA.pp.s+Lsshllo.ppL.sch..l...s.cLs..................t..p.....s...h...+sl...h.h..lss.....sh.....h.pt....ss.plhF.IpVPLl-s..pp.FslY+lsPIP..p....hsNs.....p.........h.p..ll.sco..Y..lG........l..ssc..h..c..p..Yh.L..ps..hs..sChcls.p.cphlChps.p.lhassssssh...s...Cs..l.......t......hh..+.s.....p....s.....s.......psCs.l.R.t.sc..p.p.p.lahphss..sN.sWh.h.slsc.-lsLhss..Cu..s..p...p.....p...pl.p..l..s.GoG.lL..o.l..pssChl+.......ostss......lp...............................................................................................................................................................................................................h..........................................................................................................................	0	14	17	25
+12094	PF12260	PIP49_C		Protein-kinase domain of FAM69	Assefa S, Gavin OL, Coggill P	lg7	PFAM-B_3196 (release 23.0)	Family	This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localised to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.	25.20	25.20	25.20	25.40	25.10	24.90	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.47	0.71	-4.88	36	397	2012-10-02 22:05:25	2009-08-11 16:45:28	3	7	89	0	254	354	0	186.10	26	48.34	CHANGED	lWsLLp....ps.Eal...lh.lhpc.p.-...hhP+lLGsCGchassEplshsphht..................hpphhpssWtt+u+lAltLL-hl-cl.pps..p..hahCDlshpsFGls.schc...lp..hlDhcplhscsphcphlpp.ppCpp.....s........pDCsa.hDCh.o.tCsh.pppCssphh..psN..LthlCp.p.l......hshh..........................LpGs........Ps...plppc...LpchLppCsp.	............................................hasLh.....s.E.l.lh..h.p.pc.......hs+hlG.C......G....c....hh..ssphls..p.h........................................................h.ph.h.s.ss.Wpp+s.clAlpLl-hlcpl.tpsshs..hhhsDh.....s.....hcsFuls....sc....hc.....lhhhDhcplhscsp.pphlp..t.ppCps.....s.........................pDCsh...hsCh....u...h...C..s...ptpCss.sh..ppN..LhtsCp.h.l...hshh...............................L..ss........Ps......plppp...Lpp.lppCht.....................................................	0	58	79	148
+12095	PF12261	T_hemolysin		Thermostable hemolysin	Assefa S, Gavin OL	lg7	PFAM-B_3198 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 200 and 228 amino acids in length. T_hemolysin is a pore-forming toxin of bacteria, able to lyse erythrocytes from a number of mammalian species.	20.70	20.70	21.40	21.10	20.10	19.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.92	0.71	-4.73	33	192	2009-09-11 08:17:19	2009-08-11 16:45:50	3	2	185	0	57	157	33	174.30	36	83.54	CHANGED	hthhpsscstRpplEpFIpppatpsasAclppFhPtLLul....sspupl..hAssGhRhAsppsLFLEpYLDpPlEphluphhsts.lsRspllElGsLAoh.s.sGsuphlhhslsthLhspGhcWllFTuTctLpshhpRLGLpspsLusAcss+L.scssspWGoYYcppPpVhuuslsp.uhptL	............................h.hhtsscsphscs.phlcpcYppsasAclptaMPshLuL....hs.cst...h..tussGhRh.A....p....p.pPLFLEQYLDpPs-pllupthups.lsRspllEhGpLASh.u..pGhu...thhFhhhsphLsshGa-WslFTATcsL+shhp.RhGLp.phlApAsssRl.ssssphWGoYYpppPplhAGsLspGhpt.h............	0	13	26	43
+12096	PF12262	Lipase_bact_N		Bacterial virulence factor lipase N-terminal	Assefa S	lg7	PFAM-B_3205 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 258 and 271 amino acids in length. There are two conserved sequence motifs: DGT and DGWST. This family is the N-terminal region of bacterial virulence factor lipase. The N-terminal region contains a potential signalling sequence.	20.10	20.10	20.20	20.10	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.89	0.70	-5.17	8	221	2009-08-11 15:51:27	2009-08-11 16:51:27	3	6	188	0	50	183	24	250.40	33	33.22	CHANGED	MK+p.hhhhllsSALhLuGCGD-opooGssTpss...pltpuLptETpIsFsLpu..ussslshPoYLhMDspDGTLpls...os..sssuloNPcsAMGphDGWSTo.PIslsF..pGssLssushsuulhlIKloschT....D.toss.p.lLs.ssDaslssoGsS..LhIlhLKsLssSSpYIFAVTsclpDhNGsPVGTSsSYAsLKSsshs.ssuuLsssQKVTQuoEulFutu...GVspssIVYSoWFoTQSlGDsLaAsKusTAsul..us...phssVW	.............................................MKph.lhhshlsS..AlhLuGCG.s....pos.s.p.usssp..........t..l..t..op.lpFshtu.....tsup....lPlPs.hLh....s...sp...DG....T...LplP..........ss.........sss..s.......h.sNP.h.sA.hu..t..l..DGWus.o.hP..l.l..sh................pG....s......sL...s......ss....h..............h....s....u......u.....lhlhE..l.o...s.hs........................ss..s....s..lt........t......h.......Ls.G...sD.as.......s.s.u....Su.ss........lh.IhPhKsLssuSpYlhAlTsp....lpDusG.pslusSsoYuslK..s..c............sh.....h..p..pu.......s....t...slQ.tlsp.u....hEp.l....h.t.hu..............uV.s.p..spIlYSsaFoTQS.lussLh..As+ushAssh..........................................................................	1	14	24	39
+12097	PF12263	DUF3611		Protein of unknown function (DUF3611)	Assefa S, Gavin OL	lg7	PFAM-B_3207 (release 23.0)	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 180 and 205 amino acids in length. There are two completely conserved residues (W and G) that may be functionally important.	24.90	24.90	25.20	25.00	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.13	0.71	-4.89	21	164	2009-08-11 15:51:34	2009-08-11 16:51:34	3	4	109	0	74	156	131	175.60	31	80.30	CHANGED	ssss.slp+hApslRhhGWIuFWhQlVLulVou.llLlFuslhsspstsspps.Gh...s.GlhhshhullsLhhSlahuatYsRlucpLp.t..ssstpPs+u-ss+hl+hGLllsLlGhhhullGhpAhsGhLluKulo.pssGh.....shssssphlp.uLDlhllhANssslhAHFlGllsSLWLLpplpp	................plpphutth+phGhluFWhQllLulVuuslLhFu.s...h.hsspsss...............st...........s.................s.ulhhsssGllslhhSlahuatY.hRlucpLp...ts..ssst.p.P...s+u-sh.+hl+hGlllNllGhhhullGhpAhlGsLluKulo..pssuh............shssssp..lp.uLDlhlV..AsssslhuHFlGllhSLaLLppl.........................	0	18	50	69
+12098	PF12264	Waikav_capsid_1	VSL_protease; Peptidase_C03;	Waikavirus capsid protein 1	Assefa S, Gavin OL, Eberhardt R	lg7	PFAM-B_3208 (release 23.0)	Family	The rice tungro spherical waikavirus polyprotein is cleaved into 7 proteins, including three capsid proteins, by the tungro spherical virus-type peptidase Pfam:PF12381. This family represents the capsid protein 1 [1,2].	24.40	24.40	25.50	80.00	24.30	23.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.29	0.71	-5.02	3	54	2009-08-11 15:52:48	2009-08-11 16:52:48	3	5	5	0	0	49	0	192.40	90	27.27	CHANGED	pEAFQDsEsRssDPNhSDMaNAlpuEYLVKSFoWKVSDGQDKVLuslsLPpDLWsoNSRLsDIMSYFQYYcATGlTFRITTTCIPMHGGTLhAAWDAsGCATRQGIATsVQLTGLPuhhIEAHSSSlTTloVcsPsIQSsICLSGSEHSFGRlGILKICCLNVLNAPpAATQpVuVNVWVKFDGVKFHaYSL+KsPV	.QEAHQDSSVAAAGP..TDEHNAMLQKIYLGSFKWKVSDGGGSILKTFSLPSDIWAANDRMKNFLSYFQYYTCEGMTFTLTITSIGLHGGTLLVAWDALSSATRRGIVSMIQLSNLPSMTLHASGSSIGTLTVTSPAIQHQICTSGSEGSIANLGSLVISVANVLCADSASAQELNVNAWVQFDKPKLSYWTAQHoI..	0	0	0	0
+12099	PF12265	CAF1C_H4-bd		Histone-binding protein RBBP4 or subunit C of CAF1 complex	Wood V, Coggill P	pcc	Pfam-B_318 (release 23.0)	Family	The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six [1].	22.70	22.70	23.80	23.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.65	0.72	-4.08	93	1002	2009-08-11 15:53:19	2009-08-11 16:53:19	3	13	342	12	648	938	11	71.70	33	16.24	CHANGED	p-chc.lWp....cssshlY-hlhstslpWPoLohcalPDth........sssp........tsppllhGTps......ss.......ppNhlhlhclphssp	.................EcaclW+....cssPhlYDhl.hspsLpWP.oLospalPDhp.....................sspt...........t...tsphLllGTpT.....ust..........cpNpLhlhplph.p.p............................	0	212	360	531
+12100	PF12266	DUF3613		Protein of unknown function (DUF3613)	Assefa S, Gavin OL	lg7	PFAM-B_3240 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 126 amino acids in length.	25.00	25.00	25.10	25.10	24.90	22.80	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.34	0.72	-4.46	18	138	2009-08-11 15:54:42	2009-08-11 16:54:42	3	1	135	0	44	132	2	67.80	34	59.51	CHANGED	Asps........ssuuc.hscuTcuWLtLQuss+AAu.ssQshsusptsLuhQRYL-SaKacIP-.haspptu	.........................ss..........ssssssp.hscuTcshLslQuS.G+tAu.ssQPhpGspusLuYQRYL-SFcpcIP-.aatpt..h......	0	6	15	29
+12101	PF12267	DUF3614		Protein of unknown function (DUF3614)	Assefa S, Gavin OL	lg7	PFAM-B_3244 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 162 and 495 amino acids in length.	25.00	25.00	35.60	35.50	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.03	0.71	-3.98	7	151	2009-08-11 15:54:47	2009-08-11 16:54:47	3	3	3	0	0	100	0	156.20	75	20.85	CHANGED	sFsuRhP......+ht+chsAohhcsuhuhVspuph....s.sps.shhp+Scsu....phP.sphssspsssAh.uss...VchsssSsssss...Rts.S.Pps........l+sush.lsVuuss+c.hsKlR-shhp.phGt.hpFS.F.SuT.....VhNsRssppsah...................hVhhLR.souupF.hlLh	...hsuRhP......RYEHHYDASMKGAGLSWVRKSQF....PNVEV.IRRRRSRASGSSASFPDANLQVSSDRP...SES...VQVVPMLDEGSSPP.RGVsS..PRR......DPVEGSGW.YSVGSPSR+.SSTsRGQRSA.ERGKIGDFS.FPSGT.....VYNARVDERAYK...................RVLKLRDTSASSFLRIV...	0	0	0	0
+12102	PF12268	DUF3612		Protein of unknown function (DUF3612)	Assefa S, Gavin OL	lg7	PFAM-B_3220 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 180 amino acids in length. The family is found in association with Pfam:PF01381.	25.00	25.00	91.20	91.00	20.00	16.80	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.28	0.71	-4.49	6	144	2009-08-11 15:56:56	2009-08-11 16:56:56	3	6	142	0	29	92	29	177.60	80	36.16	CHANGED	TsVSPYPHWHYFDAYuPGKLKAVYRGNGIPLPWGNMRtVcDPCQHWAVFRMIupsssGSSAQISILsVuspPRIYCCESIKVpD.AGNsHVLCAGIDLNPAI-AQGsDAlulAcpLKshCVusGGSusIPppIKp-LhSlA+ILNINWIERGIpspARLICSRGAVCPRpPSCYt....sCs	...TVVSPYPHWHYFDAYG.GKLKAVYRGNGIPLPWGNMRKVNDPCQHWAVFRRLSpPp....pGSSAQISILsVGDEPRIYCCESlNVhDPAGNNRVLCAGIDLNPAIsAQGGDALuIApELKhuCVppGGoosIPtsIK+DLpTIAKILNINWlERGI-s-ARLICSRGAVCPRpPpCYucC.G.....	0	4	9	21
+12103	PF12269	zf-CpG_bind_C		CpG binding protein zinc finger C terminal domain	Assefa S, Gavin OL	lg7	PFAM-B_3253 (release 23.0)	Domain	This domain family is found in eukaryotes, and is approximately 240 amino acids in length. This domain is the zinc finger domain of a CpG binding DNA methyltransferase protein. It contains a CxxC motif which forms the zinc finger and binds to DNA.	21.70	21.70	23.40	23.40	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.66	0.70	-4.88	6	134	2009-08-11 15:57:41	2009-08-11 16:57:41	3	9	86	0	79	130	0	213.60	55	40.04	CHANGED	AspRIhplLPQRlQpWshoPshAsEps+ctL-cIR++Qp.sRspLtELE++apcL-slIpRA+cpolspppsp......-ss-psD.-.sIaCVTCGHpIssRsAl+HMEKCatKhESQsSFGShaKTRI-G.ssLFCDhYNsQu+TYCKRLRVLCPEHoK-PKlPsT-VCGCPLVpNVFE.T.....G-FCRAPK+pChKHYsWEKlRRAEIDLERVRQWlKhDELhEQERtl+pAhosRAGlLGLh	.........................................................................................................................AssRIaplLPQRIQpWp.o.PClAEEps++hLE.cIR+cQptsRhcLp-hE+RacEL-slI.+AKpptlp..pp.c-s......s-s-.scD...s-hplaCloCGH.slss+sAl+...HME+CasKYESQsSFGSha.TRIEG..splFCDhYNPpSKTYCKRLpVLCPEHo+DPKV.........s.s.sEVCGCPLV....p...s....V.....F-hT.................G-FCRhsK+pCs+HYsWEKLRRAElDLERVR...hWhKLDELhEQERslRpAMosRAGLLuLM.............	0	27	32	57
+12104	PF12270	Cyt_c_ox_IV		Cytochrome c oxidase subunit IV	Assefa S, Gavin OL	lg7	PFAM-B_3280 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. This family is the fourth subunit of the cytochrome c oxidase complex. This subunit does not have a catalytic capacity but instead, is required for assembly and/or stability of the complex.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.94	0.71	-4.42	24	381	2009-08-11 15:57:58	2009-08-11 16:57:58	3	3	366	0	107	227	117	134.00	43	95.16	CHANGED	M+spu+lFhhlssFFhhsullYshhoth..........EWsGosALhLusuLuhhlGsYLthsuRRl....shtPEDpp-AEIsDGAG-lGFFSPtSaWPlhlAsusulsslGlA.hhh.WllhlGsshllhulsGhlFEYapGscp+	.....................MKhEu+lFthluhFallsullYhhhop...................EhAGTsuLsLouuhuLhluhYlpFsA+Rl.....-sRPED.c-AElsDGAGplGFFSPpShWPlhhAlusAlhslGls.hhh....WLhhlGls.h.llhussGhsFEYahGsptH........	1	34	84	102
+12105	PF12271	Chs3p		Chitin synthase III catalytic subunit	Assefa S, Gavin OL	lg7	PFAM-B_3298 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 332 amino acids in length. This family is the catalytic domain of chitin synthase III. Chitin is a major component of fungal cell walls and this enzyme is responsible for its formation.	25.10	25.10	35.60	35.00	23.80	23.40	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.81	0.70	-5.44	15	224	2009-08-11 15:59:44	2009-08-11 16:59:44	3	4	136	0	173	213	0	274.80	39	90.17	CHANGED	MsFGsFsoICccAuLPLCulVGs.s.p.ssspGIhPsCYuRsIELANTh.IFQhusshlHlsALlholIhIl+VRuKaTAVGR+ElloFFYlYhhLplsSLllDuGVsPPuSssasYFsAVQhGlsSAlChCLLlNGhVGFQLaEDGTslSlWhLRlsShlhFlloFhIuLsTFKuWsG......LusspTlGLFVlhYllNAlhLslYlVhQllLVlpsLp-pWPLGtIuhGlFFFlAGQVlhYsFSssICcussHYlDGLFFATlCNLLAVMMlYKaWDSITc-DLEFSVGshpssa	...........................tFGsFpshCpc.....s.....sLPlCsll.............ss........t.................................................t......t......................Gh.ssChhR........sIplus.sh...lhphushhlphhAlhhsllhlh+scpKhsAV.GR.......+EhhhFhhhYhllplhplhlsuGl.P.suusshsaFsAlphGhhuAsshsLLlNGhVGFQ..lhEDGTslSlhLlphouhshFlsohhluLsThh.uWsG..........husspsluLaVlhhllshlhLhlYhlhQllLVlpsLp-hWPhu......tlshushhFshGQVhhYshSspICpusp+YlDGhFFuTlhsLLuVhMVYKaWcSITc-DhEhsVu....................	0	48	94	146
+12106	PF12272	DUF3610		Protein of unknown function (DUF3610)	Assefa S, Gavin OL	lg7	PFAM-B_3173 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 146 and 160 amino acids in length. There are two conserved sequence motifs: FNN and IDS.	25.00	25.00	55.00	50.50	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-4.57	10	53	2009-08-11 16:00:08	2009-08-11 17:00:08	3	2	17	0	4	53	0	156.20	59	30.09	CHANGED	MpupohhFlLlslLI...uLSHuosVcp-css..uPMuM+GFNNSLGTFVEYuGQASlAocDWplpsSFNL-SLhsuIpsFp..plYKsLhDhCchp.pshCP-hh..DlTcFADoILpDGLlcsccsL-a+.....ltRLS.u---hup.hpNsoSsIDSol..NllsVulhE	...MKAIuLsFILlPlLl...ALSHGSPVsR.-AIG..GPMAMRGFNNSLGTFVEYSGQASLAS+DWcLCASFNLESLYsAIhAFN..uVYKslVD.C-cQ.ps.CPEIh.....sITcFA-SILHDGLhDLEsALcaR..........................AGRLs.u.-.DDVupELtMuTSCIDSSI..NVINVuL........	0	1	1	2
+12107	PF12273	RCR		Chitin synthesis regulation, resistance to Congo red	Wood V, Coggill P	pcc	Pfam-B_2935 (release 23.0)	Family	RCR proteins are ER membrane proteins that regulate chitin deposition in fungal cell walls. Although chitin, a linear polymer of beta-1,4-linked N-acetylglucosamine, constitutes only 2% of the cell wall it plays a vital role in the overall protection of the cell wall against stress, noxious chemicals and osmotic pressure changes. Congo red is a cell wall-disrupting benzidine-type dye extensively used in many cell wall mutant studies that specifically targets chitin in yeast cells and inhibits growth. RCR proteins render the yeasts resistant to Congo red by diminishing the content of chitin in the cell wall [1]. RCR proteins are probably regulating chitin synthase III interact directly with ubiquitin ligase Rsp5, and the VPEY motif is necessary for this, via interaction with the WW domains of Rsp5 [2].	25.10	25.10	25.10	25.10	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.25	0.71	-3.59	29	193	2009-09-11 15:13:23	2009-08-12 12:50:30	3	4	119	0	142	179	1	129.30	23	66.82	CHANGED	RWlhaslhlhslllhhhhhhphNpRRR+p.GhpPhhGTuWhs...PPsY.tQppp................pYst............hsP..sttss.t.s.hGY.Yspputa.ss.p.................h.lt.P.psh........ths.tth..hts..............................PsGPP...P	................RWhhhslh.l.lshllllhhhhph.s+RR++....p...Gh...p.....PhhG..TuWhs........sPsa..tps..pp..........................pYsts.t..st...............thsPt.Ystsss...tts.......hGh.Yst.p.sphtsssps.................................ht.P.....ts.......................................................................................................................................	0	27	69	121
+12108	PF12274	DUF3615		Protein of unknown function (DUF3615)	Assefa S	lg7	PFAM-B_3306 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is typically between 86 and 97 amino acids in length. There is a conserved FAE sequence motif. There is a single completely conserved residue F that may be functionally important.	21.00	21.00	21.90	21.00	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.74	0.72	-3.65	18	304	2009-08-12 14:43:54	2009-08-12 15:43:54	3	10	8	0	163	247	0	88.00	22	24.14	CHANGED	Yspsps.......shpY-Lhclhppshhh-ptth..apHhNFhupp+s...pt.shs.phFFAElc........stpsppVhsCs.lcsscs.....GpCauCtspsh....LcHP	...............................................t.thch.ph.ht..p..h..........p....p..tth.....a.tHlNFhApscs.............s......ss.........pLFFAElp.........................ptppt.th....hCs..lpssps.................stCh.hC..tt.....hhHP..........................................	0	0	25	96
+12109	PF12275	DUF3616		Protein of unknown function (DUF3616)	Assefa S, Gavin OL	lg7	PFAM-B_3338 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 335 and 392 amino acids in length. There is a conserved GLRGPV sequence motif.	20.60	20.60	22.80	21.50	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.12	0.70	-5.43	18	148	2009-08-12 14:49:12	2009-08-12 15:49:12	3	15	126	0	70	162	13	258.00	25	53.17	CHANGED	-hSusshssctpLWl.uuDEs.sslERLshhsss....hhssH.ppFsLu-hh-LPss..st.....EhDlEGL..Al.usGYLWlsGSHSlKRKss+spcsp.cshpcLuclph-sNRtlLuRlPl.spsssh.psspshcstp.......htAthlthpptt.s.LtphLusDPpLusFl...sIPuKDN..GFDIEGLAVps.p....RlhLGLRGPVLR.GaAlllElcsppssss..hLtLtshttpGp...hY+KHFLDLsGLGIRDL...phsGD.DLllLAGPTMc..L-Gsl+la+Wpssss...tp......tstlpphhsLPatpGsD+AEGlshhs......tsssplLlVYDSPstpRcss.ssslhuD	................................................................................uh....t..hhl.stD-...th.plh...t..........h..p....h.h.t...........tt.........DlEuh..sh..tt.......shlahhsSHu.p+pt.c....................p.sR..hlh.ph.l...t..............................................L.hphlttc..tht.hh...........thPs...ccs....G.hsIEGl..s..hss..p....plhlGhR....uP....l....h...............c....G.....hAh.ll.lps.t..ph.p...........htht.h................hchhhLcL.s.G....h.....GIR-l...phs..ss..chh.llAG.P....shs........s..Gs..hplapWsus.s.........t...........t........h.l.....s.......t.t......psEuls.h.......tt..phllh.Dts.......................................................................	0	20	49	63
+12110	PF12276	DUF3617		Protein of unknown function (DUF3617)	Assefa S, Gavin OL	lg7	PFAM-B_3343 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 179 amino acids in length. There is a single completely conserved residue C that may be functionally important.	20.70	20.70	21.00	21.10	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.24	0.71	-4.78	62	339	2009-08-12 14:49:20	2009-08-12 15:49:20	3	2	307	0	107	263	20	153.30	24	93.08	CHANGED	Mpphhhhhhhhhhh........................sssssssstpl.....csGLWEhsspht.........................................sth.....shptClotppsct.pt.........hspsppsCphpshppsusphshshsCsssth....ssspstssshssssassphshpsssst.t...hshphsh..pu+alG.sCt	.......................................................Mpphh.shhhsshh..........................huhssshA.sl.......................pPG..Wchpshph.....................................pth....t.shhs...........p...shssthChTsctscssct........hsssssuCops..hscp..o.ssplhhchsC...sssss...t..upuh..spssthSss..cFshshpusssusutt......tsst.ch..cupalG.sCs...........................	0	26	70	91
+12111	PF12277	DUF3618		Protein of unknown function (DUF3618)	Assefa S, Gavin OL	lg7	PFAM-B_3350 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length.	21.70	21.70	21.80	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-7.93	0.72	-3.93	61	612	2009-08-12 14:49:29	2009-08-12 15:49:29	3	6	483	0	202	459	7	48.20	30	32.03	CHANGED	hscs.ssplcp-I-psRscLupTlDpLss+hs.Pcplsccttsps+spssp	...........t+s.sspIcp-I-psRspLAsTl-pLsp+ss.Pppls....c-stspspshht.t.........................	0	71	147	182
+12112	PF12278	SDP_N		Sex determination protein N terminal	Assefa S, Gavin OL	lg7	PFAM-B_3366 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 410 amino acids in length. This family is the N terminal end of the sex determination protein of many different animals. It plays a role in the gender determination of around 20% of all animals.	25.00	25.00	34.60	34.40	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.22	0.71	-4.62	3	123	2009-08-12 14:53:08	2009-08-12 15:53:08	3	6	14	0	16	123	0	157.10	69	42.76	CHANGED	MKRNhSSYhHRDEKFKQLRSEDSESGLRSR...TEDERLQHRREEWhIQQEREREHEKLKKKMILEYELRRtREhchhLSKRS+TKSRSPESQDRNNAS..NTSKTlILFEKLESSDDTSLFRGPEGTQINATELRKIKl-IHRVLPGKPTTTTuEVKRDIINPEDVlLKRRT	....................MKRNhSsYSH+DE+F+QLRsE..DsE..h..sLRSR...TcEERLQHRREtWhIQQEREREHE+LpKKMILEYELRRt...R.....EhpK.......hh.......Sc.......R........S........KSRSP.-.sR.DRsN.s.S..NTSKThILS-KLE..SS..D.shS.LFRGP.EGhQINATELRKIKl-IHRsLPGKsT.......T.TTsElKRDIINPEDVhLpRRT.......	0	5	5	16
+12113	PF12279	DUF3619		Protein of unknown function (DUF3619)	Assefa S, Gavin OL	lg7	PFAM-B_3353 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are about 140 amino acids in length. This protein has two conserved sequence motifs: AAR and DDLP.	21.90	21.90	22.10	22.40	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.54	0.71	-4.07	24	136	2009-08-12 14:53:12	2009-08-12 15:53:12	3	1	134	0	61	127	16	128.70	42	91.66	CHANGED	hpEcca.A+clpttLccuss....sLPssls-R..LtAARptALup+Kspss...hhssthuhsGtuutsh............ttsahp+luhshPLhALl.s....GLlsIshapsppphsElA-lDAAlLoDDLPssAYhDpGFhtaLcps	............pEhcF.Ahcl+pALsEsuu....sLPssss-R..LAAARctALA++Ks-ss...lhss.....AhuGsuushh...........sp.tsuhh+RL...u.hshPLhsLl.s.....GLlGIshaps.pRs.sELA-lDAAhLoDDLPlsAYhDpGFstYLpp.s........................................	0	7	34	48
+12114	PF12280	BSMAP		Brain specific membrane anchored protein	Assefa S, Gavin OL	lg7	PFAM-B_3398 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 285 and 331 amino acids in length. BSMAP has a putative transmembrane domain and is predicted to be a type I membrane glycoprotein.	25.00	25.00	27.30	27.40	21.90	20.50	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.63	0.70	-4.44	11	161	2009-08-12 14:53:24	2009-08-12 15:53:24	3	2	62	0	76	147	0	172.00	43	59.27	CHANGED	RGCRLFSICQF.VscspchNsTchEC-uACpEAY.scssEQhACshGCtsQ...spsEh...cpcpLtuL.s+.t..LpslphVpsahsDlhsSAQsaI..oSoWTaYLQsDsGKlVVhQocsplphhs.........p.p..p...pt...pt.t.pss.ttshsphRs.u.p.+s...cpspsu.ht.p..t..tpsFLpChS.......+psGhspWlLsssLhLSVllhLWl	...............................................................RGCRLFSI..CpF..Vs.cu.chNpT+..hECEu.ACsEAY.sppsEQhACphGCtsQ.....P.sEh.............ppcplhsL..sp.+h.L.sLsLlpohhsDhhsSAQSFI..oSoWTaYLQADsGKlVlFQopPplphhs.........php....shpt............p......hh..sh.p.h+p..s.t.hRs...ctppps..................FLpChS.......hp...stWI......LsssLhLSVhVhLWl......................................................................................................................................................................................	0	14	18	38
+12115	PF12281	DUF3620		Protein of unknown function (DUF3620)	Assefa S, Gavin OL	lg7	PFAM-B_3384 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 281 and 358 amino acids in length. There are two completely conserved residues (G and P) that may be functionally important.	20.70	20.70	21.50	21.30	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.43	0.70	-4.62	29	119	2009-08-12 14:56:28	2009-08-12 15:56:28	3	5	97	0	66	129	4	203.20	28	62.83	CHANGED	sphsucllcAlupuGhFRhtuhllGTtAapsYsuhLGl+l.tssh.tTGDlDlAtt.tplSlsl...scshpsslhsl.Lps.h-hsFpslsphsttttsptpps....ahV-FLTspptssch.....st.hsuh.sssApsLcaLcaLlscP.lcslsltcsG.....lhVplPsPcpaAlHKLI.lus+Rp..tts.sKppKDhtQAshlhchl.spcpsppL.tp.uatcAhsR	................supllpslspsGhaRhtssllGThAatsYtshhGlch..s.sh.tTsDhDlA....phshtl.....tsph..slhpl.Lpp...t.sFc...lsphst.t..t...tspttps.........hhV-FLTsptussp...........p.h.ssh.sssApsLcaLs.aLltpP..lps.sh....ltcsG.....l.l...plPsPtpaAlHKLl.luscRp..t.s.hKptKDhtQAthlhchl.tpph.t...t.s.............................................................	0	23	43	52
+12116	PF12282	H_kinase_N		Signal transduction histidine kinase	Assefa S, Gavin OL	lg7	PFAM-B_3401 (release 23.0)	Family	This domain is found in bacteria. This domain is about 150 amino acids in length. This domain is found associated with Pfam:PF07568, Pfam:PF08448, Pfam:PF02518. This domain has a single completely conserved residue P that may be functionally important. This family is mostly annotated as a histidine kinase involved in signal transduction but there is little published evidence to support this.	22.90	22.90	25.00	23.00	22.10	20.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.45	0.71	-4.58	64	599	2009-08-17 12:16:09	2009-08-17 13:16:09	3	6	591	3	127	400	134	145.90	30	30.13	CHANGED	sLs-ll..tppTsLsss-l-aLcpllu-WQllADLoFADlllhl.........sscus.........hlsVApsRPsTusTsahsDl.VGphs...............tspcPtltcshpsGphsRstcsthtssh....slc....ppslPV+ps......s...cl...IAVls..cc..sslsss+psutLEhsahpsAs	...........lpclhtppTsLs-sDl-aLcplls-WQllADhuhADlllhV....................sccss..........hlsVAps.RP..s..TssolhpsDl.VGphs.....................................................htssc.PhVtcshpouthscs.tp...sthptsh....slc...pshPlppp..........s..cV.....IuVlh....pc....ssltstcpsuphEpsaht.....................................	0	48	97	117
+12117	PF12283	Protein_K		Bacteriophage protein K	Assefa S, Gavin OL	lg7	PFAM-B_3455 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are approximately 60 amino acids in length. This family is a protein expressed by bacteriophages which has an unknown function. There is evidence that it is non-essential for in vivo production of a mature phage.	25.00	25.00	78.10	78.00	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.72	0.72	-4.09	2	51	2009-08-18 10:28:34	2009-08-18 11:28:34	3	1	36	0	0	29	0	55.50	78	100.00	CHANGED	Mp.KhhLlhQELLLLsYELNRSGLLsENEcIps.LtpLEhlLLpsLSPSopcusKs	MSRKIhLIKQELLLLVYELNRSGLLsENEcIRsILApLE+lLLCcLSPSopcosKs.	0	0	0	0
+12118	PF12284	HoxA13_N		Hox protein A13 N terminal	Assefa S, Gavin OL	lg7	PFAM-B_3464 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with Pfam:PF00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.	19.90	19.90	20.50	20.20	19.10	19.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.86	0.71	-3.95	12	395	2009-08-19 10:03:12	2009-08-19 11:03:12	3	4	191	0	88	358	0	114.00	42	47.88	CHANGED	hD-hsKNMEGFs.GGNF....uAsQCRNLhAHPssLAP..SusYsSSEV.ssuGhuEP.uKQCSPCS.AsQuSu.uASLPYGYF.GuGYYPCRMSHH....sulKSCAQ..s..uSa.u-KYMDTSso.GE-F.oSR	..................................................h..................s.ssh...........sAspC.RsLh.......uH......P.........u......s...hs.s...........u..u.....u......h.....s.....o.......u..p.............s...s.....s...s..u....h....................uE..........s....sKQC.....u..P..Cs...A.s.....Qu..SS...s.A......uLP...YGY..F...GuGYYsC.R.huHp.......sulKSC.uQ.............su...uua.u-KYMDTS....s....s.....s...uE-a.sSR.......................................	2	5	13	40
+12119	PF12285	DUF3621		Protein of unknown function (DUF3621)	Assefa S, Gavin OL	lg7	PFAM-B_3468 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 49 and 62 amino acids in length. There are two conserved sequence motifs: QPLDLS and EQQ.	25.00	25.00	30.70	30.70	24.60	16.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.60	0.72	-3.81	3	129	2009-08-19 10:07:37	2009-08-19 11:07:37	3	6	13	0	0	96	0	49.00	78	16.18	CHANGED	KPCPEPs......TEsQPLDLSQKKEKQoEHEQQVsKPlKsQKNEPQPYSQTYGK	......KssPEPE......sEuQPLDLSQKK.....EKQPEHEQQVVKPhKPQKsEPQPYSQTYGK.	0	0	0	0
+12120	PF12286	DUF3622		Protein of unknown function (DUF3622)	Assefa S, Gavin OL	lg7	PFAM-B_3490 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 72 and 107 amino acids in length. There is a conserved VSK sequence motif.	20.30	20.30	20.30	21.10	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.21	0.72	-3.67	15	92	2009-08-19 10:16:05	2009-08-19 11:16:05	3	1	91	0	24	68	4	70.60	58	53.13	CHANGED	MocsKKa-aRlsppcsuWsAEITR+lTuR+TlVSKpcsGFuoEAEApsWuEpELpuFLpN.tcRNcRKA-p	...MocsKKFshRlopc+sGWsAEIT..RphTSRKTlVSKRcsGFsTEAc....AQsWuEpELtuFlps.s.RNERKucp.................	0	2	7	16
+12121	PF12287	Caprin-1_C		Cytoplasmic activation/proliferation-associated protein-1 C term	Assefa S, Gavin OL	lg7	PFAM-B_3504 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteristic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.	25.00	25.00	25.80	25.80	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.29	0.70	-5.05	6	155	2009-08-19 10:17:39	2009-08-19 11:17:39	3	3	40	0	55	136	0	264.70	48	39.45	CHANGED	QGsYNFMQDSMLEF-GQsLDPAIVSAQPMKPsQsMDh.QMVCPPsHsESRLuQPsuVPVQPEsTQVPhVSsss-saoooPPlYQPSHTsEPRPQs-slD.IQASMSLsoEQoPssSSLPuAsQPQVh.....KPLHSSGINVNAAPFQSMQTVFNhNAPVPPsNEs-oLK.psQYQuSYuQuFSSQstHsVEQoElQpEQLQoVVGuFHopDQshppus....uuHQQPopQGsGFsRpuQSFYNSRG.MuRGGPRNsRGhlNGYRGsSNGFRGGYDGYRPPFuNTPNoGYG.QsQFST.PRDYSNssYQRDGYQ.NaKRGuGQGsR	....................................................................................................................................QGshNFhQ.............-ShL-F-p.s...........sAIs..SuQ..P.pss...............ssss......p.....tE..ppL.up.sph....p..s.psTp..ss.hsss.s..s...s.h.......s.ss..................h.ps................ocs..t..p...p...tt..s.......-..p..ss...h....s...spp..o....shuSs....P..sh.u..p...QsFQ..........pP...p.S.S.uls..lN..sA.PFQ.uMQT..VFNhNAPlPPhpE...Ehhc.ps.pYpuuYNQSFoo...........ts...........ppspQs..pL............p.....p.pl......Qo..s.....V.......ss.....hcs.....s.....ssp..p...ss....Gsht..PtQsssFPRssQPahNSRG.ssRGssRGuRulhNuYRuP..sGa+..tGaDuYRs.......shs.sss.Nus..Ys.Q.QFsA..R-YSu..Y.QRD..s.aQQsaKRGuspus.s..........................	0	3	7	19
+12122	PF12288	CsoS2_M		Carboxysome shell peptide mid-region	Assefa S, Gavin OL	lg7	PFAM-B_3507 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 430 amino acids in length. This family is annotated frequently as a carboxysome shell peptide, however there is little publication to confirm this.	20.00	20.00	21.10	20.00	16.80	19.90	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.81	0.70	-5.31	13	104	2009-08-19 10:28:48	2009-08-19 11:28:48	3	3	69	0	42	110	359	315.70	37	60.72	CHANGED	NsSRAlVLARREA.SK+GKoA.......upQsoouAuVARQuNPDlSSRElAQ+VRELRSKsGAs....ssppsGsoRPsGPNRs.....GuKQ.uuAuDAHWKVGtSETsoGQsVTGTQANR.ShKTTGNEASTCRoITGTEYLGAElFpoFCQ.SpPthtQPuKVsVTsTSHGN+VTG.NEVGRSEKVTGDEPGTCKslTGTEYISANQSssYCGs.sssSP+KVGpShTpsGppVSGVhVGRSp+VTGsEuGus+pLTGDQYLGu-P.s.sGRuspKVuShpTL+GsGVTGTsVGRo-pVTGsEsGSC+pVTGDEYIGuQQYcuFCus+PpPEAsKVGhSlTN+uQhVSGTpTGRSphVTGDEPGTCKAVTGTPYAGLEQuspaCsssulp-l+pRTPpphuTsu.sphTGlQPGIGGVMTGA-KGACEslTGTPYVGuDQhutAC	................................sR.hs..hRtA.stttt.t......................ths..........t.......t........h.ss+phu.t.hRt..s..Gt.......tt....s+Psu..+t..................................h..KVt.upT.tGphVTGTpspc.s.+sTGsEsuoCRslTGTEYhG..sE.hp.p.hCp.ttPt...tP...+..VtlotTsp..uppVoG.splGRSp+VTGDE.GsC+tlTGTEYluupp...hC....s..s......t.s.t.plh.s.ottsp...loGs..tps..........ttVTGsE.....Gs.spplTGspYht.............t................tup...s.....stK.Vu..pTlpGps...VTGT.Vu+usplTGsE.GuC+.VTGspYluspphpshC...ss.pP..s.p...stKVuhshT.csp.VoGTtsGRSttVTGsEsGsCpslTGTsYh.G..ppht..thCss....tt.t...h...t........h.oG..p..G.ss...hTGstpGtsp.loGo.Y.G.tt.....................................................	0	11	25	38
+12123	PF12289	Rotavirus_VP1		Rotavirus VP1 structural protein	Assefa S, Gavin OL	lg7	PFAM-B_3516 (release 23.0)	Family	This domain family is found in viruses, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF02123. VP1 is a structural protein of the inner core layer of the rotavirus virion. It complexes with VP2 and Vp3 to form this layer.	19.40	19.40	20.80	35.70	17.50	15.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.57	0.72	-4.34	2	470	2009-08-19 10:32:54	2009-08-19 11:32:54	3	2	231	10	0	377	0	51.00	94	5.17	CHANGED	ScGItlTEKAKLNSYAPlhLEKRRsQhShhlohLQpPsoFKSpp.lTINDlL	..SKGIAVTEKAKLNSYAPVYLEKRRAQISALLTMLQKPVSFKSNK.ITINDIL.	2	0	0	0
+12124	PF12290	DUF3802	topoisom_IIA_B; Topoisom_IIA_B;	Protein of unknown function (DUF3802)	Assefa S, Gavin OL	lg7	PFAM-B_3547 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 143 amino acids in length. There is a conserved KNLFD sequence motif.	20.80	20.80	21.00	94.70	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.39	0.71	-3.77	17	157	2009-12-04 10:35:14	2009-08-19 11:36:19	3	1	156	0	31	85	9	112.40	60	96.12	CHANGED	MVs-pDGYhpLIpYLT-pLuLFE.tspssssus-TVh-lhE-plAsplhhVCsQNspLshspR.hllRElDAIVhDLEElLuuVhsppsTsEQhtFIsEFsuLlKNLFDptluch	MVVETDGYLALIEHLo.NhslFs...ppGDTGsEoVEDVlTDMlASNIMuIFEQNPELHSSVRFpLLKEADuVVtDLGEVLAGVWt+sATNEQIuFLDEYIuLVKNLFDoAVAKY.	0	4	9	20
+12125	PF12291	DUF3623		Protein of unknown function (DUF3623)	Assefa S, Gavin OL	lg7	PFAM-B_3578 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 261 and 345 amino acids in length.	18.90	18.90	19.70	19.40	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.72	0.70	-5.42	30	93	2009-08-19 10:44:53	2009-08-19 11:44:53	3	4	86	0	33	90	126	256.20	37	85.67	CHANGED	MsshhlssLhAlFlWWFSTGllLhll+h.sc+....sathuhlhussllshGlhGlssotsssoluuuYlAFhuALhlWGWhEluFLsGhlTGPppssCPssspGhcRFhpAhtTlhaHElsLlssslslhhlohGusNphGlWTFhlLahhRlSAKLNLFLGV.plNsEFLPstLtaLtSaF+ppshshlFPlSVoshTsssshhhppAhss.ssstptlGasLLusLsALAlLEHWFhVLPLPstpLWpWhLPutpssspsst	........M.shhlssLhAlhlWWFSTGhlLhLsph.sc+.....sathohlhusslhshulhGlssoupssossuAYhAFssulhlWGWhEhuFLsGhlTGP+ppsCPssspuhpR.FhtAltThl.aHElullsssshlhhlohs..usNplGhWTFhlLahhRhSAKLNLFLGV.slNs-aLPppLtaLpSYFp+cshNhlFPlSVTlsThssshhhppAhss.ssshptlGhsLLusLhALAlLEHWFhlLPLPsttLWpWsl.sptt.....s.......	0	8	20	23
+12126	PF12292	DUF3624		Protein of unknown function (DUF3624)	Assefa S, Gavin OL	lg7	PFAM-B_3603 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved GRC sequence motif.	21.30	21.30	36.80	36.80	20.60	19.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.66	0.72	-3.58	18	129	2009-08-19 10:46:14	2009-08-19 11:46:14	3	1	129	0	25	82	4	77.20	60	92.95	CHANGED	MuCpsC.....ppshFppKIGRCpRCMhQ..LTlLSlluWslWaahatDsPpslpSIALLhhshAFoGLLhLHL....llhsaRphps	..MACs-C.....ppchFWpKIGRCpRCMDQ..LTVLSVlsWIlWaauF+-cPtSIESIuLIhAGFAFNGLLFLHLWh+aVILPWR+Rp.G.............	0	2	7	16
+12127	PF12293	DUF3625		Protein of unknown function (DUF3625)	Assefa S, Gavin OL	lg7	PFAM-B_3621 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 360 amino acids in length.	18.30	18.30	18.50	18.70	18.20	17.90	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.41	0.70	-5.25	15	185	2009-08-19 10:51:41	2009-08-19 11:51:41	3	4	145	0	18	138	16	235.40	47	72.93	CHANGED	PLoP-Q.IcpLRphh--sp+Atutssss...ssPRlSSlsVNLSPGAo.PllRsusspsoolsFoDuTGuPWsluAssl............suss....ssFslpahtsSsllslQAtp.YssGNloVhLcGLssPVllsLpoGc......sptVDhRlDLRlPtRGPsAps.h..shspspluhhsssLpuFLDGlPPcc..A+RLKssGs...-spsWths-cLYlRTphs.lpstFcpohSSsDGT+lY+LPhT.PhVshShpGpsssLpI-h	.....................Lss-p.I+pLRplhs-s-+Ahsushso...ssPRlo.SloVNLSPG.A.SlPllRsuhs.lSsloFsD.sGuPWP.ussPh.............................susP....phFsl..Q.a........s.....sNhlslpsh+sausGNloVaL+GLusPVlLslsSG-sss............s.opphDuRLDLRlPppGPsuss..s...uhs...............ss........+.......luLaDssLQuFLDG..lPPc-..s+RLKhoGss..sDTplWQp.GD....-....LhVRoRsh.LpspF-pTloSA....DGTHla+LPsT..PlLoFS.l..sGpslplpsE.h.....................	1	8	11	14
+12128	PF12294	DUF3626		Protein of unknown function (DUF3626)	Assefa S, Gavin OL	lg7	PFAM-B_3627 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 374 amino acids in length.	20.10	20.10	20.60	20.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.89	0.70	-5.38	7	296	2009-08-19 10:53:28	2009-08-19 11:53:28	3	4	251	0	60	210	3	194.40	35	57.46	CHANGED	RlALHFHPDRlDs+GhoVsEGLLc-GlY+sQFETplSNGplSs..GGsRDaWEppLFGsuYp....shcpRPKYGAL-LhhhPsGPAPRFGSCYhlh+spVhuRsTFoahDSa..psP+-KGTlppFDslLAALLsEoFpRpaA...........LGppslpPspllc+LsppLppsh.sth-tssutNLDHYIEAQIHGslSLscDlthLVADPSF+GTsIGc.LpplCc+YtIsLpWHsGhpLsVpcVPsDFRGsuMPsLApRI.....AhstslDAhhIGtAAtcLp+pPppWS-RGshtcshp-LKhLWHVLV+a	.......................................................................................................................................................sspRPhYuALshh..t.sGsA..s..taGpsaF.LsspV......pspsTao.hDoa......p.sh-puphpp..F.h.........h.p.hA............spss.hhs......hphh....ppLht.....hpt.hh.......h.hs.p....ss.t..spYIEApIHG-lsLhcDlctl...l.-sSa.pto.....plht.........................................................................................................................h............................	1	20	37	49
+12129	PF12295	Symplekin_C		Symplekin tight junction protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3634 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a single completely conserved residue P that may be functionally important. Symplekn has been localized, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Careful analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited, partly but specifically, to the plaque structure of the zonula occludens. 	25.00	25.00	36.20	31.70	24.40	21.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.17	0.71	-4.37	34	216	2009-08-19 10:55:50	2009-08-19 11:55:50	3	7	161	0	151	211	2	171.50	39	15.68	CHANGED	Dlchll.PllstLcKc-l.hpllPcllph.......s.phhppsls+lLp..............stspts.slossElLlhlHsl........sshKpl.lcAhshCFspps........h..asp-llutsLspls-p.....ssl..PhLahRTllQshptaPsLpsFlh.plLs+Ll.pKplWcp.splWcGFl+CspphtP.....pSatlllpLPstplpphlpch.	.......................................................Dl+hLIPllsuLpKcEl.lthLP+llpL.......s..hlcpshsRlLt........................tsspshssLsPsElLlA.lHsI.....-stc..ssh..........Kpl...lcAsshCFsp+s..........laTp-VLusshpQLh-p..........sPLPhLhMRTVIQuls.....haP.pLssFVh.slLsRLl.hKQ.............lW+....splWcGFl+CspphpP.......pSatl.lL.Q.LPstQLttshpp............................................	0	65	92	126
+12130	PF12296	HsbA		Hydrophobic surface binding protein A	Assefa S, Gavin OL	lg7	PFAM-B_3635 (release 23.0)	Family	This protein is found in eukaryotes. Proteins in this family are typically between 171 to 275 amino acids in length. Although the HsbA amino acid sequence suggests that HsbA may be hydrophilic, HsbA adsorbed to hydrophobic PBSA (Polybutylene succinate-co-adipate) surfaces in the presence of NaCl or CaCl2. When HsbA was adsorbed on the hydrophobic PBSA surfaces, it promoted PBSA degradation via the CutL1 polyesterase. CutL1 interacts directly with HsbA attached to the hydrophobic QCM electrode surface. These results suggest that when HsbA is adsorbed onto the PBSA surface, it recruits CutL1, and that when CutL1 is accumulated on the PBSA surface, it stimulates PBSA degradation.	22.40	22.40	22.40	23.40	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.36	0.71	-4.27	71	311	2009-08-19 10:58:29	2009-08-19 11:58:29	3	9	66	1	199	305	0	119.30	19	53.41	CHANGED	+cssslhsslss.IssplsslssslpsYs.....GG.......shslhsstsslhsslppuhpssps.s..ssloss-uhslhsslt...sLpspltsslssllsKKsthss.......uGhushlhssLpp.pssssshusslpsK	...............................thsshhpslss.lssplp..plssslp.sas.....Gu........sh.tlhssssslhsslppu.hpslps..s...ssL.ost-uhslhss.lp...sLp.splpsslssllsKKs.hsp.......sGhsshlhtsLpp.psssppLuptl.tK...............................	0	28	86	153
+12131	PF12297	EVC2_like		Ellis van Creveld protein 2 like protein	Assefa S, Gavin OL	lg7	PFAM-B_3668 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.	25.00	25.00	50.80	30.80	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.23	0.70	-5.84	5	63	2009-08-19 11:04:06	2009-08-19 12:04:06	3	2	35	0	29	54	0	376.80	49	36.14	CHANGED	GEpauVSYTApL-u+cltsGES...LcLPApLTFpSuSQNcTs...QL..........ossFTITlEEpspVhPNHGlHAAGFllAFLVSLVLTsAuhFlLsRTpsLpsshLoRsRpp+cE....SKLEsusFoSu-sluEDluhNDQllDILThEEPGsMLQALE-LEIATLsRADADLEAsRhQIsKDlIAlLLKNLlSuGHLSPQlE+RMuulFKKQFLsLEsElQEEY-RKMlALTAECsLEoRKKMEuQ+QREpsApEEAEELlK+ssE+sAlECSsLL-pLHuLEQE+Lp+pLtLcQEE-FAKA+RQLAVaQRsELHsIFaTQIcsAspKGEL+.EsAKpLlc-YSKsQ-slEELMDFhQAoKRYHLu+RFAaREYLV+sLQupEo+lpuLLNTAATQLssLIpKhERAGaLcE-Qh-MLLERAQsElhSlKQKLDcDLK	..........G-tasVsYsApLputclh.sG.Es...LpLPApLTFpSsSpNco.......pL..........pAhholsspEphpVhPsHGlHuAGFhlAFllSlVLThsshF.hhs+hpslptshls..cpp...h.p.-........sKL..E....FsSu-uVsED..luhsDQhlDILo.E-PGsMlQALE-LE.....lATLsRAD.....ucLEAsRhQIsKD..lIulLLK.sLsSs.GHLSsQsE++huulFKKQFLhhEsElQ.EEY-RKMlALTAECsLEoRKK.hEsQaQREhsAhEEAEELhK+.suEcsAhECs.sLLcpLHtLEQ-cLp+pLhlppEEshAKApRQLAla........pRsELHpIFasQlcsAlhpGEL+.EsAKhLlpcYuchQ..-slEELMDFhQAsKRYHLu+RFuaREYLVpslQS.-o+lpuLLSoAusQLspLIpKpERAGaLcE-Qh-hLLERAQsElhSlKQKLDpDLK...................	0	7	7	12
+12132	PF12298	Bot1p		Eukaryotic mitochondrial regulator protein 	Assefa S, Gavin OL	lg7	PFAM-B_3672 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 381 amino acids in length. Bot1p localizes to the mitochondria in live cells and cofractionates with purified mitochondrial ribosomes. Bot1p has a novel function in the control of cell respiration by acting on the mitochondrial protein synthesis machinery. Observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms.	21.90	21.90	22.10	22.00	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.94	0.71	-4.32	23	175	2012-10-04 14:01:12	2009-08-19 13:06:09	3	4	149	0	139	193	1	150.20	25	45.85	CHANGED	slpPFP.NPphhoshllSE-L+pcIaccltppuh..SlppVSpcaGlcl.RV-AlV+LhclE+cW.......pschps.hpsaucslhcMhPh..........htsptthtcE.................sls-lPV.ptshsphFhsluEScsFs.lDAA+lhph..tPAs-php+hpshstctpstpp..tpp.pp...hchlhsptpcuE	...............t..pPFP.Ns.hhop.lLS-ph+ppIacplh........ppsh.............olctlStcaslchpRVtAll+LhplEcpa............tpptp.hhhshscshhpMhPh...........tst..h.tE................................................sls-l.s.ph.....s..phFhslsESc.Fs..DAu+hht....ss..t....p.ht.....t..tt.......................p.................................................................................................	0	51	86	122
+12133	PF12299	DUF3627		Protein of unknown function (DUF3627)	Assefa S, Gavin OL	lg7	PFAM-B_3687 (release 23.0)	Family	This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF02498.	20.90	20.90	20.90	22.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.74	0.72	-3.94	56	290	2009-08-19 12:19:57	2009-08-19 13:19:57	3	9	69	0	2	291	1	90.20	23	28.40	CHANGED	hhp+h.ph.spcslthPsssppp.pLslhpp......s.spathlpuQcpplcpphp+hp......shsllh-.shcPNshsshNplp-pl....ppc..phchp+p	.................h..p+hs.h.sp-tlhhPs-spppppLslhpp..............tsspashl+sQcpthcpphc+hp......stcllhc.shpPNshshhNplK-pL....tpc..phphpt.................	0	0	0	1
+12134	PF12300	DUF3628		Protein of unknown function (DUF3628)	Assefa S, Gavin OL	lg7	PFAM-B_3692 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 153 and 183 amino acids in length. The family is found in association with Pfam:PF00270, Pfam:PF00271.	25.00	25.00	110.40	109.60	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.37	0.71	-4.24	3	35	2009-08-19 12:23:46	2009-08-19 13:23:46	3	1	34	0	8	33	1	174.10	59	30.83	CHANGED	EQKIPVEPVTsELLTPLPRPER.AsstGEEu-DssGDSVGsIFREAREsRAA-EtRRGGGRSGPG..uRSGust.G+GsRDG.cGG-GRsRsP.RKPRlEGEpDuAAsuAsTPVsuAuAscsP........ulsAA-GE+sPRKRRRRR+GRPVEGAEuV.sus..sssAuPhpPsQVVAKPVRsAAKoGupPSLL	.EQKIPVEPVTuELLTPLPRssR.ssstGEEA---.sGDSVGsIFREAREQRAA-EpRRGGGRSGPG...uRSGu...GtGRR-....G..sGu-G+sRs..RKPR.VEG....Et..s.uAAsustsPVsuAuAs.psP.........usssA-GERsPRKRRRRRpGRPVE..GAEsu.Aus..sssAuPhpPsQVVApPVRsAAKsuupPSLL...........................	0	1	4	6
+12135	PF12301	CD99L2		CD99 antigen like protein 2	Assefa S, Gavin OL	lg7	PFAM-B_3714 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 165 and 237 amino acids in length. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum.	23.50	23.50	23.70	23.70	21.90	23.40	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.23	0.71	-4.57	13	175	2009-09-13 06:10:09	2009-08-19 13:25:43	3	7	56	0	65	166	0	141.50	29	62.51	CHANGED	FDLuDAh......................................ccssssss..........pcPssPKKPusG...............t-FDLtDAlssssshs.t.+sss+spspst............uGuhSDsDLtDssspsshpsDtstsGuus................................sscsstpppstsGhIAGIVuAVusAllGAlSSaluYQKKKLCF........ppu.st.........+ssssEP	...................................................................................................................sppst........................ps.hssp.tPsss................ssFD..Lt.DAlssps.s..............t.s...........................sp.p.................suGsauDpDLtDhhtssth+scts..tussst...t..............................ppss..sttsstsGhIuGls.uAlshAllGAlSSYluYQpKK.hCF..........tt..............................................	0	5	10	25
+12136	PF12302	DUF3629		Protein of unknown function (DUF3629)	Assefa S, Gavin OL	lg7	PFAM-B_3723 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 292 amino acids in length.	25.00	25.00	28.20	25.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.73	0.70	-5.00	3	44	2009-08-19 12:28:29	2009-08-19 13:28:29	3	3	6	0	2	44	0	239.70	74	86.97	CHANGED	NSWKNSGFElRSGVAuACRLPKCPTLQRIPTN+DVNcK.EKPYSTFKIDHD..RIQ-MWQRSRIGAKEQNSLRGYQPANSDVNTDS+EVISALDKVRRIEERRKIQNKMRALMEEQHM+DERIQEEpDRVIRKEVLVERDPARKQTspEYSPVRNREKCKPsoWVSATVLAATGKMQQHRYMQTPP.KhNPIKVEAEVQpPSKSVP-NPAoGTTSGQPNQT+T..DMoSRAKWAKSlLELHKTRAKEMDDILSLsGYSN	..........................NSW+pStFt.RsGlAusscLPpCPTLQRIPTNcDVNcK.-pPYSTFKIDHD..RlQpMWQ+SRIGAKEQNSLRGYQPANSDVNTDScEVISALDKVRRIEERRKIQNKMRALMEEQHM+DERIQEEpDRVIRKEVLVERDPARKQTspEYSPVRNREpCKPsoWVSATVLAATGKMQQHRYMQTPP.KhNPIKVEstsQpPspSs.tpsAssTTSGQPNpTpt..sMspRscWsKuhLELHKpRAccMDclhSLtGYSN...........................	0	1	1	1
+12138	PF12304	BCLP		Beta-casein like protein	Assefa S, Gavin OL	lg7	PFAM-B_3744 (release 23.0)	Family	This protein is found in eukaryotes. Proteins in this family are typically between 216 to 240 amino acids in length. This protein has two conserved sequence motifs: VLR and TRIY. BCLP is associated with cell morphology and a regulation of growth pattern of tumor. It is found in adenocarcinomas of uterine cervical tissues.	21.00	21.00	21.10	32.60	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.26	0.71	-4.87	9	123	2009-08-19 12:34:45	2009-08-19 13:34:45	3	2	38	0	53	105	1	160.80	47	83.93	CHANGED	MKhGLsLllVGHVNFlLGAlVHGsVLRHlus.ppulshpYsluNlluVsSGlLuIhsGIsAIlhSRNLtphsLpWsLLVlSllsuLLSsACslGLllulshTluspG+sLlusCs..hsss....cphslus-CPFDPTRIYuToLsLWsPslLhSssEushSsRChhlshplhtLtPCtccthptphppts-	.............M+sGLsLlllGHVsFlhuAllHGoVLRaVusspsAls.pYsssNllSVsSullslssGlsAllhSR.L.....p..L+WslhshulhssLLShsCulGLLhululThAstG+tLlusCp..h.ss......c.hshss-CPFDPTRIYsosLsLWh.ullhsssEsshushCs.hshpLhtltPhhtct.pt.h.....p........	0	2	7	22
+12139	PF12305	DUF3630		Protein of unknown function (DUF3630)	Assefa S, Gavin OL	lg7	PFAM-B_3766 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue D that may be functionally important.	25.00	25.00	27.60	26.90	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.18	0.72	-4.10	23	171	2009-08-19 12:35:54	2009-08-19 13:35:54	3	1	171	0	37	112	8	94.20	45	93.84	CHANGED	hplsphphscssL.Lshsu.lDF-sFtthAEsLlttLsspVlE+QWuADRHpWLL-FEGspLhLpaEaYu-hsWLsstpts-.hEVLsaLAsLhpp	....................................FuLs-YhsscG+Lllpsps.FDF-sFsphAppLlslLuApVlEKQhDADlHoWLlDFEGspLhL+....uEHYSpulWLEsLsss.p.ucEpLsalApLhp.............................	0	7	13	26
+12140	PF12306	PixA		Inclusion body protein	Assefa S, Gavin OL	lg7	PFAM-B_3786 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 191 amino acids in length. PixA is thought to be specifically produced in Xenorhabdus nematophila. It is an inclusion body protein.	20.80	20.80	22.30	21.60	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.19	0.71	-4.41	33	128	2009-08-19 12:40:52	2009-08-19 13:40:52	3	2	61	0	31	100	3	167.10	25	93.80	CHANGED	hsphIDlllslDs-p....Ihp.......thsphSpsssp..PTsI.s..ppt.......lYhlsspsphh............supusucLplpsplGDslRWRsoSlot.ss-hslllYchhthss.......hhs......hpsshhphsssspP..sPss......sshsspppshp.haapusltspGp.tsathsFulasp.....pppLhGYapWDPhIslt	.....................phlDlllslDs-t.Ihp.........ph.sssSpsPst...PTsl.s.....pct..........lYhlssss.hs..................supusucLplpAslGDhlpapsTSlst.su-pusllY..phhttsu.......h.s......hsssh.phssu.spP..sPss.....ppshsstppshp.hhapupVtp...sGp...tsathsFulash..................ppsLhGYahWDshIpl.................................	0	4	9	16
+12141	PF12307	DUF3631		Protein of unknown function (DUF3631)	Assefa S, Gavin OL	lg7	PFAM-B_3787 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are typically between 180 to 701 amino acids in length.	20.80	20.80	20.80	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.46	0.71	-4.38	22	155	2009-08-19 12:47:29	2009-08-19 13:47:29	3	10	132	0	41	145	32	176.80	39	38.04	CHANGED	+MRRRsssEpVtsaRhRpststhpsL+p+LspWhpsphsplcs.Ac.........PshP......t.lpDRAADsWEPLlAVADhAGGsWPp+ARtAulslss.ptspstt....sShsscLLtDlR.ssFtt.tst...ptlsos-LLstLpt.pEuPWus.hs.spsLssppLuphLpc.Y......sI.....cSpslRh..susp.sKGYp+...ssFtDAWsRY	.............................+MRRRtssEpV.csaR.RhstsphctL+-+LAsWssshtstlpp.uh...............PsMPtsVpDRsADsWEPLlAVADsA.GGcWPcpARsAshphss...u.scstp.....sSlGlpLLpDIR.clF.....sst.........-ph.Tu-lLstLpp.-EuPWus.hp..GcsLssRtLuphLtc.Y......uI.....psp.h+...uups.hKGYpp.........spFtDAWsRY.............................................................................	0	13	30	35
+12142	PF12308	Noelin-1		Neurogenesis glycoprotein	Assefa S, Gavin OL	lg7	PFAM-B_3817 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF02191. There are two conserved sequence motifs: SAQ and VQN. Noelin-1 is a glycoprotein which is secreted mainly by postmitotic neurogenic tissues in the developing central and peripheral nervous systems, first appearing after neural tube closure. It is likely that it forms large multimeric complexes.It has a divergent function in neurogenesis. In animal caps neuralized by expression of noggin, co-expression of Noelin-1 causes expression of neuronal differentiation markers several stages before neurogenesis normally occurs in this tissue. Finally, only secreted forms of the protein can activate sensory marker expression, while all forms of the protein can induce early neurogenesis.	25.00	25.00	49.30	49.00	23.20	21.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.33	0.72	-4.21	8	216	2009-08-19 12:51:08	2009-08-19 13:51:08	3	4	46	0	85	186	0	96.70	65	23.41	CHANGED	asuPEEGWQVYSSAQDsDGRClCTVVAPsQshCSRDsRSRQLRQLhEKVQNlSQShEVLDLRTtRDLQYVRshEslhKsL-sKL+ssp-s.+sLsAKuaQE	...........hsPEEuWQVYSSAQDs-GRCICTVVAPpQshCSRDARo+QLRQLLE.K.VQNMSQSIEVL-hRTQRDLQYVc+MEsQMKGL-uKF+QlE-s++phhu+pFp.....................	0	5	16	38
+12143	PF12309	KBP_C		KIF-1 binding protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3821 (release 23.0)	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 365 and 621 amino acids in length. There is a conserved LLP sequence motif. KBP is a binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a type of kinesin interacting protein.	20.10	20.10	20.30	20.50	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.16	0.70	-5.49	21	192	2009-09-12 21:52:06	2009-08-19 13:56:09	3	6	137	0	122	185	3	298.00	31	58.76	CHANGED	.h-WAlNAATLSpaYhuptpatpARHpLuAAshlh........sp..p.........t...stptct-pp..............-shcpphAclApsWsKYsLplLpsup.p.....hhc-s.sc.t.php.phpthp........h.....tp...................c..................h.tl........c.ltuhEsplssphshsF--A+tlFhhuppalscAK-aaph-GasT-HlcIlQDhupLa+tLAFFE.psh-.................ppsKMHKRRschLEslhs-LNspaYhtlsRplhaElucsat-Mh-l...................+lt.tc....stptsss+slpK.lNplsppulcaappFl-oh+..............pss.tchPcp..l-pD.h+PhhhA+F+lARLatKllos-spppl-slssSLphYchhscaspppsp...stt.h.psElpls+EMlpLLPhKlpclp	................................................................................................................................-auhNshpLupaahs......pa..put..ppLsuuphlh.....................................................................................t................p.hppt.uplshsah+atl.hhptsp.h........................htp.p.t...p.t.t.......thtt.......................................................................................................................h..h................lts.hcp.pl.sh.hhshsFc-ARplFhhupcalp......cAKcaapl..........-uasT-HlcllQDhStLa+hLAFFE.psh-.................+psKMHKRRlshLEs...lh.s.pLN....s.paYh....h....l.....sRp.l.aElucsah-hh-l...............................+lthhp....p......ppsssch...lpK....lNplsppulcaaphFlcohp.....................................psp..t.h.tp...htp-.hcshhhAhFplu+lh.Kl.hss.sstpplcpltpulphYphh.t....hht.................h......hth..ph..h...p..............................................................................	0	47	57	98
+12144	PF12310	Elf-1_N		Transcription factor protein N terminal	Assefa S, Gavin OL	lg7	PFAM-B_3835 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.	22.90	22.90	23.90	22.90	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.56	0.72	-4.11	11	183	2009-08-19 12:57:33	2009-08-19 13:57:33	3	4	40	0	81	167	0	91.20	44	17.08	CHANGED	MusslQss-LlFEFAS......ssh.-ctpQhs-sssaPAVIVEpVPpAcLhphYuG..Lsh--p.shhhpDss...tEcpl.....-slhLo.......spsp.ssscpT.cTlpAAEALLsM-SP	.................shslp..st.lhEhsS................ssh.-p.pp.t....csu.aPAVIVE.VPsuc...l...p.Yuu.....Lshs-t.s.hhp-ss....tEp.pl.p...ssh.s.lp.................spsps......ssscsTscTIEAAEALLpM-SP......................................	0	5	12	36
+12145	PF12311	DUF3632		Protein of unknown function (DUF3632)	Assefa S, Gavin OL	lg7	PFAM-B_3839 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 170 amino acids in length. There is a conserved ALE sequence motif.	20.70	20.70	22.50	22.40	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.35	0.71	-4.48	45	228	2009-08-19 12:58:27	2009-08-19 13:58:27	3	6	62	0	179	234	0	178.10	17	56.69	CHANGED	WphlhphApphshsp.t.........Q-+LVplltplpphssh......................t.hhspptplWp..-LPhhu.......php-tWs................ssssspptpcalNhsuFhA+Lsupshssh.............shaulhsl+suLE..................c.sss.phpstls...sAuhWlhhuGpplhphstth.t.t..tt.st...............hpup...sshshcRWphWccRh	............................................................................................a..hhphupths.pp...........pscLlphlhtlpphssh................................................hh.pttplWp......-.LP.hhs.......thp-h.at...............................................tttsstptppahNhsuFhA+Lhstshhsh..............shhulhhh+puLE................................................................p..ss..th..sshl.sAstWlh..hu..uptlhp.s...tt.t...t.......t........................ts....tsh...s.pRW.hWppph..............................................	0	22	73	140
+12146	PF12312	NeA_P2	NeA_polyprotein;	Nepovirus subgroup A polyprotein 	Assefa S, Gavin OL	lg7	PFAM-B_3843 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 259 and 1110 amino acids in length. The family is found in association with Pfam:PF03688, Pfam:PF03689, Pfam:PF03391. This family is one of the polyproteins expressed by Nepoviruses in subgroup A.	25.00	25.00	159.40	25.30	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.88	0.70	-5.15	4	141	2009-08-19 13:02:51	2009-08-19 14:02:51	3	6	6	0	0	143	0	229.50	76	29.65	CHANGED	MsKFYaSsRRLssashups.+..GohEQWLtshE.DsuFRtpVKpcV.hsRth.ss.RhFpa.lGhGPl-sPthhsWtallpG.....s..........PTpPVKAcEVVssPQPK.VVIPSPPPsPp.PYFRsVGAFAPTRSGFIRATVERLoREREESRAAALFAELPLEYPQGAPL+Lolu.KFAMl+...HTTWR+WYDTSDERlhcsHPGGPsL...PPPP.IQpPPSFpERlpphCphpsCuRAFALETSLGLNhAWVshVsIPSISlCC	.........................MsKFYaSsRRLAsas.ups.HLGGSVEQWLAAIpTDPSFRQTVKEDVQtNRpcPsAIRMFSWKlGaGPIDNPppCsWHFVLTGE..RPsQ...........PocPVKAcEVVVsPQ.........sK.KVVIPSPPPsPs.PYFRsVGAFAPTRSGFIRATVERLTREREESRAAALFAELPLEYPQGAPLKLSLAMKFAMLK...HTTWRKWYDTSDERLhcAHPGGPCL...PPPPPIQpP.PSFpERVREhCRhKSCARAFALETSLGLN+AWVGlVDIPSTSVCC..	0	0	0	0
+12147	PF12313	NPR1_like_C		NPR1/NIM1 like defence protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3871 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with Pfam:PF00023, Pfam:PF00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.	25.00	25.00	33.80	33.20	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.27	0.70	-4.90	21	173	2009-08-19 13:19:32	2009-08-19 14:19:32	3	15	50	0	40	169	0	153.10	51	34.03	CHANGED	+RLTRstDYpspTEpGp-osKsRLCI-ILEp-..hR.....sPhsu.-sSso..shhuD.DL+M+LLYLENRVAhARLLFPtEA+lAM-IAps-uTuEFssh.s...spsosuphppVDLNETPhh.pc+hhsRhcALoKT............VEhG+RaFP+CS-VLDKhh....pDDLs...DlhaL-+sTsEEpp.KRhRahELp-sVpKAFoKDKt.Ehs+SuhSSSSSSo	..............+RLTRstDYpspoEpGpcusKDRlCI-lLEpE..h+.....p...h..p.s..s..hhs-.phphcLL.LENRVuhA+lhFPhEAchsMpIAphcsT.EFsh...s....t..sttphppsDLN.sPhh.....pcchhsRhpAL.KT............VEhG+RaFPpCStVLs+hh....t-...D.s...phh.htpsTs-cp..K+.RahELp-...l.+AFscDpt.p.sh....tss..........	0	5	24	32
+12148	PF12314	IMCp		Inner membrane complex protein	Assefa S, Gavin OL	lg7	PFAM-B_3921 (release 23.0)	Family	This domain is found in bacteria and eukaryotes. This domain is about 120 amino acids in length. This family is the inner membrane complex of parasitic organisms. This is a cytoskeletal structure associated with the pellicle of these parasites.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.72	0.72	-3.84	22	202	2009-08-19 13:20:31	2009-08-19 14:20:31	3	6	25	0	158	206	7	80.50	33	25.71	CHANGED	sK.hhpE+lcpVsKhlhc..EKlVEVPcl+aV-KIVEVPph.hhpK..hVPKh.lpEpll.hP+...h.pc.h.....+hV-lspl+-ls+ac-hEtsEElhchl	.............hhpEplhc..V..PK.hhp..EKlVE........VPp.lch....V-KlVE..VPphhhhpK.h.......VP+s.lp....Eplh.hs+...h........h...........................................	0	62	92	140
+12149	PF12315	DUF3633		Protein of unknown function (DUF3633)	Assefa S, Gavin OL	lg7	PFAM-B_3949 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 210 amino acids in length. The family is found in association with Pfam:PF00412.	20.30	20.30	20.70	21.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.48	0.70	-5.02	17	151	2012-10-03 04:41:15	2009-08-19 14:21:26	3	12	38	0	112	165	9	180.60	46	40.97	CHANGED	uLsMKl-QplPhLLVERpALNcAh-uEKpGpa+h...sETRGLCLSEEQhlsol......ccs+hG.sppll.shhTEPp+LsR+.CE..VTAILlLYGLPRLLTGuILAHEhMHAWLRLpG.apsLss-VEEGICQVluHhWLEuphhsuss...........ttuuussssuusoSKKu.tpSpaEKKLG-FahHQIcoDsSssYGDGFRpu.tAVp..caGL++TLcHI+hTG	.....................................................................shsM+l-Qpl...PhLLVERpALN-AhpsEKpu....h.ah...h................scTRGLCLSE.E.Q.hlpol............+pPphu.st..p...hh.shhops.+l....s.Rc..CE...VTAILlLYGLPRLLTGSILAHEhMHAaL..RL..p.G...at...sLss..cVEEGICQVluahWLE...uclhssss..........................................ssssss.sssssso...++u..thophE++LucFhhcQIcsDsSssYG-GFRsu.pAVt..p.aG..LcpTLcHl+hT............................................	0	34	77	95
+12150	PF12316	Dsh_C		Segment polarity protein dishevelled (Dsh) C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3969 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 177 and 207 amino acids in length. The family is found in association with Pfam:PF00778, Pfam:PF02377, Pfam:PF00610, Pfam:PF00595. The segment polarity gene dishevelled (dsh) is required for pattern formation of the embryonic segments. It is involved in the determination of body organisation through the Wingless pathway (analogous to the Wnt-1 pathway).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.98	0.71	-11.52	0.71	-4.21	8	185	2009-08-19 13:22:41	2009-08-19 14:22:41	3	12	44	6	82	166	0	185.80	54	29.69	CHANGED	NMAsLSLNDpDGSS.GASDQDTLAPLPHPuAAPWPh.h.uFPYQY.PsPHPa.P..PuYp-..uaSYGuGSAGSQHSEGS+SSGSsRStuttp+pt..cp...............uucpsuGSGSES-aoo+uuhtRt.tccuPstptusssScsSh+u...................uhupppopsShusPGlP..YssshLh.hsssssss..........PPGAPP.VR-LASVPPELTASRQSFphAMG	..................NhAsLsLNc.-GSS..GASDQDTLAPLPp.P.uA.uPWPh...h...uFP...........Y.Q.Y.PsPh.Ph.P..Pu.Y...p-..ua..SY..G.uGSAuSQHS.....E....GS+SSG.SsRSsuttp+ptc.ct.................tspppuGS..G.S.ES-hos+uu...p.s.hcpsssp.ptu..sp....u.ts......................................thpp.ttpssh.ssPGhs..Yss.hhhh.sss..s..s...............................PPGuPP..sR-LuuVPPELT..uSRQSFphAMG........................................	0	7	14	35
+12151	PF12317	IFT46_B_C		Intraflagellar transport complex B protein 46 C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3974 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 298 and 416 amino acids in length. IFT46 is a flagellar protein of complex B. Like all IFT proteins, it is required for transport of IFT particles into the flagella.	21.10	21.10	31.90	31.90	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.51	0.70	-4.97	13	166	2009-08-19 13:23:45	2009-08-19 14:23:45	3	3	118	0	110	161	7	199.20	49	58.91	CHANGED	GuYcPt-YspLsVos..El+-LFpYIs+YpPpsh-LssKLKPFIPDYIPAlGDlDAFIKVPRPDucP-sLGLpVLDEPsspQScPsVlsLpLRp..........hucptststsshVsslccA-pN..PKtI-sWIsslpElH..+sKPssTVsYo+sMPDIEsLMQEWPt-hE-lLps.ltlPou-lDhDLppYschlCuILDIPVa.....sshI-SLHVLFTLYpEFKsNQHF	...........................tYsPs-YccLsVos..ElKELFpYIs+....YoPQhl-..L-tKL+PFIPDaIPAVGDlDAFlKV.....PRP..............D...........s........c.....s......D......sLGLh.lLDEPu.spQSDP.oVLsL.Lpp.........................ss+pt.s.h.s..p..phhV....+SlE.s..A-..+.s..PKsIDpWIpsIp................-LH..+oK..PssoVpYs+.sMPDI-sLMQ-Ws.cF.....EE.....hLsp...lpL...Ps.u.....clDssLscYlchlCsl..LDI..Plh..............pshIpSLHlLFoLY.EF+sspHF.............	1	50	61	87
+12152	PF12318	FAD-SLDH		Membrane bound FAD containing D-sorbitol dehydrogenase 	Assefa S, Gavin OL	lg7	PFAM-B_3647 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 168 and 189 amino acids in length. There is a conserved ALM sequence motif. This family is a membrane protein (FAD-SLDH) involved in oxidation of D-sorbitol to L-sorbose.	23.00	23.00	23.00	23.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.03	0.71	-4.57	25	189	2009-08-19 14:35:08	2009-08-19 15:35:08	3	3	141	0	74	162	5	156.60	31	88.15	CHANGED	uloRRplL......hsshussushsstshs.t.hsss.sssss.tsFhslSptLTs...+psL-stlupRlasALhppss.........pFssplspLtslls......ssp.htphpsts.s..lpssspsIlsAWYpGsVtcs.......cuplluYcsALMapsspDsLhlPTYCsssPhaWssp.Pstlss	............................hoRRphL..........sshuhs....us..shsss...h...sht..shs..ss.ssssslssFhsLSptLTu......+psLs...tslGpRlhpuLtcsss.........phsspLsp.Ltshls...............th..sss.s...psluhpIlpAWYhGlV..................cstll....sYcpALMapslpDsLll.oYssstPsaWspp.P.t..s..............	0	12	28	55
+12153	PF12319	TryThrA_C		Tryptophan-Threonine-rich plasmodium antigen C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3676 (release 23.0)	Family	This protein is found in eukaryotes. Proteins in this family are typically between 254 to 536 amino acids in length. This family is the C terminal of a surface antigen of malarial Plasmodium species. It is currently being targeted for use as part of a subunit vaccine against Plasmodium falciparum, the main species involved in causing human malaria.	22.10	22.10	22.10	24.00	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.44	0.70	-5.15	52	134	2009-08-19 14:41:50	2009-08-19 15:41:50	3	3	9	0	89	162	0	199.00	31	46.96	CHANGED	cWpsWhpcLEp.-WcpFptpl-pcK.pcWlppK-c-WppWlcphcpKWh+Yscphcp.-apsslhcpu.sWs-ppWcpW.lco-s+phhct-accWlppscpplspahhccW.pWKspK...lhpWLhp-WKpcEschWpcacptph.hchhphtc..+cpWhcWpcRlpcEpp-WppWlctK-phhlps.chspWpcWKs-KpthaspWhcsFlpcWlscKpWphWh	......cWppWhppLEp.-WctFptpl-pc+.pcWhcpK-c-asp.Wlpph-sKWhpaspsh-p.Eapsshh+cs......sWs-.p.pWcpW.lpTcuKphhct-accWlpppcstlspahhpcW.pWKspK...hhpWlhs-WKpcEpphWtcapptph.hphhphtc..+ppahpW+pRlp+Etp-WppWlphK-phhlps.chspW.cWKp-KphhaspWhcsFlspWIpcKpWp.Wh................	0	4	9	65
+12154	PF12320	SbcD_C		Type 5 capsule protein repressor C-terminal domain	Assefa S, Gavin OL, Bateman A	lg7	PFAM-B_3790 (release 23.0)	Domain	This domain is found in bacteria and archaea. This domain is about 90 amino acids in length. This domain is found associated with Pfam:PF00149. SbcD works in complex with SbdC (SbcDC) which is a transcription regulator. It down-regulates transcription of arl and mgr to inhibit type 5 capsule protein production. It acts as part of the SOS pathway of bacteria.	24.30	24.30	24.30	24.30	24.10	24.20	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.26	0.72	-3.97	203	1897	2009-09-13 17:34:05	2009-08-19 15:46:33	3	3	1883	8	311	1271	34	98.00	23	25.01	CHANGED	sshp.sltplc........usl...cclhptl..........tt...........t.ttpt...................salclpl..pscphh..schhpc.lcphhssh.....lclphphtp.pptt.......tpptpslpcl.ssp-lFpchhpppptp	............................shpshthlc.......Gsl....splhpph............tp.......................................tpps........................saLclcl...pscphl..hDhh..p+.lcplhssl..........Ltlcp.sptp..ppp..........pppptslp.c.h..ss.-lFpchhtt.t..s.................................	0	103	188	252
+12155	PF12321	DUF3634		Protein of unknown function (DUF3634)	Assefa S, Gavin OL	lg7	PFAM-B_3607 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.	25.00	25.00	40.00	39.90	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.24	0.72	-4.10	19	141	2009-08-19 14:56:50	2009-08-19 15:56:50	3	1	140	0	30	92	5	101.20	51	97.32	CHANGED	hlhhIlluhh.llahLlhss+...slhch+Fc-G+lsppKG+lP.pFp+ss+cIA+pp.h.oGpl+s.+.psss+LchStsVscplpQRIRNlF...Papta..Kstssp..+pu	......MLYVIllAsh.lIFWLlhlDR...PlLhVpFKDG+lspsKGHhPPoF+HNlh-IAp+-PF.oGElKVYppRoG.sKLsFSKpVPKKlQQRIRNVF...PHQGFs+pSsshKKt.t..........	0	5	10	21
+12156	PF12322	T4_baseplate		T4 bacteriophage base plate protein	Assefa S, Gavin OL	lg7	PFAM-B_3861 (release 23.0)	Family	This protein is found in viruses. Proteins in this family are typically between 208 to 249 amino acids in length. This protein has a single completely conserved residue S that may be functionally important. This family includes the two base plate proteins in T4 bacteriophages. These are gp51 and gp26, encoded by late genes.	24.50	24.50	24.50	24.90	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.21	0.71	-5.07	18	130	2009-08-19 15:13:34	2009-08-19 16:13:34	3	2	86	0	0	114	1244	193.00	25	91.02	CHANGED	hchKlssGs+..+a+sFTVpEYpsll......pspt.pc.pphlscll.sph......htclsppppEalFlplastSlGKs.lchphpCspCuc.ptph.lslpptpl......ps.hhpsuslpIph+aPch................cshtchlscCI-plhts.cp.ashcDLs-pEpppll-hlohcshccIhcthps.s.lhhsltlpC..sspppshslpGLtshFc	................................hchcl.sss+.lph+sFTlc-...aptLl........pscp.tphpphlppll.ssh.......hpcLspt-tEhlalplhspSlGcs.lchpapCs...................p...................Csp.ch.h.lsLpph.pl.....t...cs.hh..h.ss.lpIph+aPp.h.t.................................cshtchlsssIcslhss.sp.hs.hc-ls-............p............-....hpclh....chls.pphppIt.c.hhpp..Pplh.hsl.lpC.psGpppshslcGLtphFt.................	0	0	0	0
+12157	PF12323	HTH_OrfB_IS605	HTH_14;	Helix-turn-helix domain	Bateman A, Gavin OL	lg7	Pfam-B_1210 (release 3.0) & Pfam-B_4602 (Release 7.5)	Family	This is the N terminal helix-turn-helix domain of Transposase_2 Pfam:PF01385.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.29	0.72	-4.63	231	3827	2012-10-04 14:01:12	2009-08-25 09:44:16	3	12	1203	0	846	3330	126	44.80	31	12.81	CHANGED	M.........h+...uaKaRlaP.spcQpphlt+phGssRaVYNhsLstppctYc..p.stc	...........M......pua+h+lhP.stpQpphlp+thGssRalaNtsLshppctacttt.............	0	214	582	720
+12158	PF12324	HTH_15		Helix-turn-helix domain of alkylmercury lyase	Bateman A, Gavin OL	lg7	Pfam-B_3505 (release 6.5)	Domain	Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. This is the N terminal helix-turn-helix domain associated with Pfam:PF03243.	21.30	21.30	21.30	21.90	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.43	0.72	-4.32	6	128	2012-10-04 14:01:12	2009-08-25 11:23:53	3	4	102	13	18	80	9	73.50	39	34.60	CHANGED	ptpplusplspthspGptspuhshLaRPLLp.LApGcPVohEslAstTG...+ss-cVtpVLpptPusEhD-cG+IlG.hG	..............................phus.l.pphspsp.ssuht.LhhP...LL+.LAc.GcPVohpsLAuthG...hPsEcVtpVLpph..s..u..sEYDcpGpIlG.aG...........	0	10	14	17
+12159	PF12325	TMF_TATA_bd		TATA element modulatory factor 1 TATA binding	Wood V, Coggill P	pcc	Pfam-B_97264 (release 23.0)	Family	This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes [1]. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs [2]. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal [3] and plant [4] cells. The Rab6-binding domain appears to be the same region as this C-terminal family [3].	28.70	28.70	28.80	28.90	28.60	28.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.48	0.71	-4.38	78	241	2009-08-27 10:02:35	2009-08-27 11:02:35	3	5	216	0	179	241	2	116.50	33	13.47	CHANGED	hsshhuhsssstussspllE+huuslRpLEuElssh+pElu+LpspRsphppElVcLhcEsEch..+ptspclppLcpplcsLcpRapssLphlGEKoEpVEELcsDlsDLKchY+pQV-phl	................................h......pssthussspllEphpupl+phE.............uElsphpp.ElupLpppRsphppElVc....Lhpps-ch.........cptspclt.pLcpplccLcp.RYpohLphhGEKsEclEEL+tDltDlKphY+pQl-phl..........	0	52	92	144
+12160	PF12326	EOS1		N-glycosylation protein	Wood V, Coggill P	pcc	Pfam-B_29822 (release 23.0)	Family	This family is not required for survival of S.cerevisiae, but its deletion leads to heightened sensitivity to oxidative stress. It appears to be involved in N-glycosylation, and resides in the endoplasmic reticulum.	21.50	21.50	22.70	21.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.14	0.71	-4.56	19	118	2009-08-27 10:17:50	2009-08-27 11:17:50	3	6	105	0	85	125	0	130.70	34	35.05	CHANGED	psRuSEahLsulWClVSuYLoYulLDuLMVRWIlpYSTsAAIlRhhSMSh..lhIThEhhLluuhSsp.tcYhLHsWIlISChLThsYIhQsalTSNLphh.......................................................................................thpppRphDlYpIsVFsVVPVGlASFlTMlGLLRsLh	.......................p....sEhhLs.lWChsohYLoa.hhDsLMsRWllpYos.AsIlRlLohss.......h..h..lThplLhLouhS..s-..chhL.sWIhIussLThhYhh..........................................................................................................................................................................................................................................................................................................h........................................................................................	1	20	45	71
+12161	PF12327	FtsZ_C		FtsZ family, C-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	pcc	Prosite	Domain	This family includes the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ is a GTPase, like tubulin. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea.	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.94	0.72	-3.92	26	5666	2012-10-03 12:11:42	2009-08-28 16:26:11	3	7	4977	45	1192	3761	2518	93.00	47	24.25	CHANGED	GhAMMGhGpAsG...-sRAt...cAscsAlssPLL-..lslpGA+GlLVNITGG.DhoLtEs-ssuptIp-tlD.s-AslIaGsslDsphpsplRVoVVATGlc	........................GpAhMGhG.A.sG.......EsRA.h...cAActAIuSPL.LE...ss.lpG.A.c..GV..LlN.I......T........GG..........D..........l.....oL..hEhppAus....h.lp..pt.s.....s........p........s.....A..s.l.....I.aG.s.s.l.D...p...s.h...p....D..c..lRVTVlATGh....................................	2	392	791	1014
+12162	PF12328	Rpp20		Rpp20 subunit of nuclear RNase MRP and P	Wood V, Coggill P	pcc	Pfam-B_33537 (release 23.0)	Family	The nuclear RNase P of Saccharomyces cerevisiae is made up of at least nine protein subunits; Pop1, Pop3, Pop4, Pop5, Pop6, Pop7, Pop8, Rpr2 and Rpp1. Many of these subunits seem to be present also in the RNase MRP, with the exception of Rpr2 (Rpp21) which is unique to RNase P. Human nuclear RNase P and MRP appear to contain at least 10 protein subunits, Rpp14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, Rpp40, hPop1 and hPop5, although there is recent evidence that not all of these subunits are shared between P and MRP. Archaeal RNase P has at least four protein subunits homologous to eukaryotic RNase P/MRP proteins [2]. In the yeast RNase P, Pop6 and Pop7 (the Rpp20 homologue) interact with each other and they are both interaction partners of Pop4 [4]; in the human MRP Rpp25 and Rpp20 interact with each other [2] and Rpp25 binds to Rpp29 (Pop4) [3].	24.60	24.60	24.60	24.60	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.70	0.71	-4.54	44	133	2012-10-03 06:24:24	2009-08-28 16:42:55	3	3	129	1	93	213	7	130.40	29	71.76	CHANGED	phtpslYVsopTPahSulKRlpKhLcptp+..........................pt.........tt..................tt..t...............c.Vhl+uhG+AIpKslslutaF...pcp......shcVclpTuoVpVlD-lh...........................................................................................................s-tc-cpscsRpRhVSsVElp	.........................................p...pslaVsopTPahStlKRlpKhLctst+.....................pt..............................................t...............tppt.Vhl+GhG+.AIpKslslutaF.......pppp......shpVplpTuTVplVD-lh.tt........................................................................................................................................................scscscpspsRhRtlSslclt.........................................................................................................................................................................................	0	19	39	65
+12163	PF12329	TMF_DNA_bd		TATA element modulatory factor 1 DNA binding	Wood V, Coggill P	pcc	manual	Family	This is the middle region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures.[1]. The whole proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein.  TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal [3] and plant [4] cells.	35.00	35.00	35.00	35.20	34.90	34.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.44	0.72	-4.17	51	411	2009-08-28 15:49:32	2009-08-28 16:49:32	3	20	270	\N	165	357	0	74.30	39	10.97	CHANGED	sshpcplpEKDppIspLhcEGppLS+p-hcppspIKKLRtchp-t-..pplsph.p...p+hpch-pclpplcpchcpt-	...................t..htppLttKctplAph.pE...hEKL.cs...cupo.ccLcpcscEsE..+phscLp....pKls-LEcElssLchhLsus-............	0	41	75	128
+12164	PF12330	DUF3635		Domain of unknown function (DUF3635)	Wood V, Coggill P	pcc	Wood V	Family	This family may be a potential Haspin-related leucine-zipper. A leucine zipper was proposed to be present towards the C-terminus of human Haspin, (up-stream of the current family) [1]; however, as this domain would appear to span several helices and be largely within a loop structure [2], the actual zipper might be further downstream, and be this family, which is the very C-terminal part of the Sch. pombe sequence.	21.60	21.60	21.70	21.60	21.00	21.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.47	0.72	-3.92	6	219	2009-09-03 10:35:38	2009-09-03 11:35:38	3	7	187	7	156	232	1	85.70	24	13.60	CHANGED	c-LFsGcG.........DYQF-IYRLMRp.hps..sWupFcPhTNlLWLaYLocplLpKhshKohs..sssshRphhcpI...........pch+phhhshcSto.hpCuc.Lh	...........................................hFpG.p.s..............chQa-lYRhM+p.hps.............sWp..papPhTNllWLpYLhcpLlpphp.hpph......pt.........p.............................................................................................................	0	61	91	130
+12165	PF12331	DUF3636		Protein of unknown function (DUF3636) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 160 amino acids in length.	25.00	25.00	75.40	46.00	21.60	17.20	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.78	0.71	-4.63	17	75	2009-09-03 15:34:27	2009-09-03 16:34:27	3	2	70	0	58	70	0	145.80	35	19.84	CHANGED	suTcsLpLLYhhAsuChp................pspslppFW+plpaDFlLhMLssp.QslsDIhLhLslLSTSlhssSFGsl.so.......cpcQhssEN...aIlDRlusLLsEhPpsD.......EGttPaoshclhphRLEslthLTpluFssh.....tptuuhhlApHPoALuRLlRshaDEL	................ssTcsLplLYhhAhuChp.......................spps.ppFW+phphDFlLhMLssp.Q.hsDIhhhLpLLsTShhssShGPl.ss.......cspphsspp.............hIIDRVushLsEhP...........sptshoshclsslRltAhphLsshAhosh..........uuhhlApHs..sAlsRllpslpspl......	0	8	25	44
+12167	PF12333	Ipi1_N		Rix1 complex component involved in 60S ribosome maturation	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 91 and 105 amino acids in length. This family is the N terminal of Ipi1, a component of the Rix1 complex which works in conjunction with Rea1 to mature the 60S ribosome.	21.50	21.50	21.50	22.40	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.26	0.72	-4.05	43	316	2009-09-03 15:39:04	2009-09-03 16:39:04	3	6	274	0	202	292	0	102.20	27	18.54	CHANGED	sssslpsahphllhalpuAMTHls..scIRtsohchLshLlchsspp.....sptsahK..hLpsahslLuhs.....tst.........s.shs....hstst............pstcthsphLpsLtpFL	.......t..ppltsahsllhsalpuAMTHls..tsIppDSlclL-lLLcthPs.................hs.s..thsp........lLps..Flplluap.......tpp..................ht.shs.ttp....................pstphphphL.tLtpFL......................................................................	0	59	101	160
+12168	PF12334	rOmpB		Rickettsia outer membrane protein B 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 220 amino acids in length. The family is found in association with Pfam:PF03797. This family is the middle region of one of the outer membrane proteins of Rickettsia which is involved in adhesion to eukaryotic cells for uptake.	25.00	25.00	115.00	115.00	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.40	0.70	-4.97	9	158	2009-09-03 15:40:00	2009-09-03 16:40:00	3	2	90	0	6	136	0	200.30	77	15.45	CHANGED	INFAu.s.ussDTlLNVGcGVNLYATNITTsssNsGSFsFsAGGTNIVSGTVGGQQGNKhNsVpLDNGTTspFLGNAhFNGtTTIcuNSTLQIGGNYTsDalp..SADNTGIVEFVNscsITVTLNKQAssVssLKQITVSGPGNVVINpIGNAuNshGhsTsTIuFpN....ASLGAsLFLPSulPhDs......LTIKSTV...GNGssGs.FNsPhVlVSGlDSsIAsGQl	.IpFus.u.spsDolLsVGcGVNLYAsNITTssANsGSFhFpuGGTsIVSGTVGGQQGNKFNTVsLDNGTTVKFLGNATFNGpTTItANSTLQIGGNYTADFVA..SADGTGIVEFVNTsPITVTLNKQAAPVNsLKQITVSGPGNVVINEIGNAGNsHGAsTDTIAFEN....SSLGAsLFLPSGIPFNDAGNhhPLTIKSTV...GN.cTAsG.FDVPtVIV.GVDSVIADGQV	0	1	1	1
+12169	PF12335	SBF2		Myotubularin protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with Pfam:PF02141, Pfam:PF03456, Pfam:PF03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.67	0.70	-5.03	11	260	2009-09-03 15:43:16	2009-09-03 16:43:16	3	40	96	0	156	235	0	186.70	35	14.02	CHANGED	PhGPsls.......slh-cpsssh.NSA...RRLEVlRNCISaIF-NKhhEA+KohPAVLRuLKu+sARlsLscELsh+sQpNRs.lLDHQQFDhVVRhMNsALQDsSuhDEauVAAALLPLoouFCRKLusGVpQFAYTClQDHsVWsN.QFWEssFYp-VQspI+uLYL...........................t.t.sppp.pstsstscstEpoAl-lAA-QhRhWPTlsc-cQpELlppEESTlaSQAIHaANpM	...............................................................hht.....h.sSA...pRLEVlRsCl....shlF-sK.....hh-scKhhPAshRsL+s+sAR.sLspELth.a........lp.p.N.......+A..hLDcQQF-..hllRhMNssLQ-..sos..h-Easl..AAuLL.PLs.osF...hR........K.L....us...G...l...pQ.FAY..o.slQ........-H.slWps.QFWEuhFYs...sVQp.pl+...sLYLp...............................................pp.t......t.........t..t.p...t.t.......sp.tp.os.h-lss...pQ.t.....s..ht.t.ptphhppEEshlhuQAhHaAshM...............................................................	0	45	61	105
+12170	PF12336	SOXp		SOX transcription factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00505. There are two conserved sequence motifs: KKDK and LPG. This family is made up of SOX transcription factors. These are involved in upregulation of nestin, a neural promoter.	22.10	22.10	22.10	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.16	0.72	-3.37	6	314	2009-09-03 15:46:08	2009-09-03 16:46:08	3	3	110	1	118	281	0	77.80	43	26.18	CHANGED	YRPRRKTKTLLKKDKYSLPGsLls..ssusss..sVusG..hDsY.sHMNGah..NGuYShMQ-.QLuhspHsshss..............ppl.HRY	............YRPR..RKTKTLhK.K.D....KY...s...L.P....u..s..lls...................ssu...sh...t..........sVu.....u....................h.s........th..shh.NGa.......suu...t............hhtc..Lu......Qh.u.hsu...........................................................................	2	18	32	68
+12171	PF12337	DUF3637		Protein of unknown function (DUF3637) 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00073, Pfam:PF08935.	25.00	25.00	134.10	133.10	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.32	0.72	-3.99	2	82	2009-09-03 15:48:34	2009-09-03 16:48:34	3	4	13	0	0	84	0	67.00	90	4.17	CHANGED	MACLKhFSLKsKsKsHSYSPRtlELKaN.DFsFKPRPLAsLLRLEPSDoKhRRVECsEVEhDSWYPN	MACLKIFSLK+KsKSHSYSPRtlELKYNSDFAFKPRPLAPLLRLEPSDTKTRRIECAEVEYDSWYPN	0	0	0	0
+12172	PF12338	RbcS		Ribulose-1,5-bisphosphate carboxylase small subunit	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00101. There is a conserved APF sequence motif. There are two completely conserved residues (L and P) that may be functionally important. This family is the small subunit of ribulose-1,5-bisphosphate.	25.00	25.00	28.00	26.30	22.50	20.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.37	0.72	-4.19	46	352	2009-09-03 15:49:56	2009-09-03 16:49:56	3	4	116	0	42	353	0	40.00	53	24.28	CHANGED	ASShh.So.AsVAo....RsssAQA.oMVAPFsGLKSsuuFPlTRKsNss	..............uuhh..so.sshss............ssupA..ohVAPFsGLKSoA.uFPVo.RKsss....	0	6	22	34
+12173	PF12339	DNAJ_related		DNA-J related protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 130 amino acids in length. The family is found in association with Pfam:PF00226. There is a conserved YYLD sequence motif. Mostof the sequences in this family are annotated as DNA-J related proteins but there is little publication to back this up.	25.00	25.00	42.80	29.00	24.20	15.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.72	0.71	-4.27	41	208	2009-09-03 15:51:57	2009-09-03 16:51:57	3	2	207	0	51	141	15	125.50	47	61.22	CHANGED	tpsPLlhsllplLpp.pspuhp.apLhppLpppshh..splc.ssptsLF+ppFLLhNALYpLQppLhscp..hLplpshsIpLh..sh..tsssts..h.....t....sDsLRcYYLDWpsa.csspspVccLLssFWpcap	.......................................-NPLlWPIhplL+c.pPpGWKlHsLAscLpchGhh....ssL..D.pPccDLFKRNFLlMNALYQLQ-pLaP-p..WLQVcAMsIhLhshhp......sp.tp..l......-....sDPLR-YYlsWpNY.-ssEu-V+RLLspFWoRYp.............	0	13	25	40
+12174	PF12340	DUF3638		Protein of unknown function (DUF3638)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There are two conserved sequence motifs: LLE and NMG.	25.00	25.00	25.60	27.30	23.00	21.80	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.41	0.70	-5.37	26	218	2009-09-03 15:54:27	2009-09-03 16:54:27	3	22	110	0	186	233	13	197.50	30	6.43	CHANGED	GHsNWcPh-aP-WLLLEIEusIhIRpsQhpVAtphIsPsuGsNuVLQhNMGpGKoSVIlPMVAusLAssspLlRllVPKsLhpQstQlLpo+LGGLlsRclhHlPFSRcTpsststlpthpplaccshppuGllLs.PEHlLSFKL.GLpplh-u+hs.ApshlchppWhcphuRDllDESD.sLulKhQLIYs.GoQpsVDGpPcRWplsQsLLuLVppashsLppca	..................taps......PcaLlhEh-sslhlRttQh....p....lApp.h.h.s.....s...t..ps..pss.lh.QhpMGpGKooVIhPhluh..h..L......A....ss..p........p...LlpllVscs.Lhpph.hphLpp+l.u.u.l.l.sR.plhplPF..........sRph..p..h.s................p.......t.h..ph....h.t..phhppsh.p...ptG.ll.l.spPE..p...lhSh.....p......Lh.s.....l......p.p.h.....h......p...t..p..........t..............s..........pt........hhp....htp.hh.p.p...sp......D...llDEsD..ht.h+hpLlYs.Gtt.slp.t..s.RW.hhptlhthh...........h....................................	0	70	126	164
+12175	PF12341	DUF3639		Protein of unknown function (DUF3639) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00400. There are two completely conserved residues (E and R) that may be functionally important.	21.60	21.60	21.60	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.76	0.72	-6.62	0.72	-3.94	35	247	2009-09-03 15:55:19	2009-09-03 16:55:19	3	17	204	0	161	240	3	26.90	40	2.85	CHANGED	GEplpulAsussalsVsTStsalRlFo	....sEplpAlulupu...alAssTSspalRlFo.	0	38	75	125
+12176	PF12342	DUF3640		Protein of unknown function (DUF3640) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 25 and 211 amino acids in length.	25.00	25.00	45.10	44.30	17.50	16.00	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.59	0.72	-6.63	0.72	-4.41	5	29	2009-09-03 15:56:06	2009-09-03 16:56:06	3	4	2	0	0	24	0	25.10	79	5.26	CHANGED	MSLLTNRhCRRVDKDQWGPGstGRTP	MSLLTNRhsRRVDKDQWGPGshG+sP.	0	0	0	0
+12177	PF12343	DEADboxA		Cold shock protein DEAD box A	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 68 and 89 amino acids in length. The family is found in association with Pfam:PF00270, Pfam:PF00271, Pfam:PF03880. This family is the C terminal region of DEAD box A, a protein expressed under conditions of cold shock which is involved in various cellular processes such as transcription, translation and DA recombination.	22.50	22.50	22.90	22.90	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.90	0.72	-3.72	6	500	2009-09-03 15:56:51	2009-09-03 16:56:51	3	4	494	0	21	135	1	63.20	88	10.05	CHANGED	GGERR..GG...GRs.FuGERREG.....GRp..G-RREGuss........uGERR.u...RDGQR..APRRDDuAA.......ssRRRFG.DA	.........GGERR...GG.....GRG.Fu.GERREG........GRNFS.GERREGGRGDGRRFSGERREG....R........APRRDDSTG............RRRFGGDA..	0	1	5	13
+12178	PF12344	UvrB		Ultra-violet resistance protein B	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00271, Pfam:PF02151, Pfam:PF04851. There are two conserved sequence motifs: YAD and RRR. This family is the C terminal region of the UvrB protein which conveys mutational resistance against UV light to various different species.	21.20	21.20	21.30	26.80	20.90	18.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.14	0.72	-4.43	509	4463	2009-09-03 16:03:57	2009-09-03 17:03:57	3	9	4402	11	984	3212	2153	43.90	56	6.48	CHANGED	hYADc.lTcSMpcAI-ETpRRRphQhtYNccHGITPpo.lpKplp-	.......hYAD+..ITsSMpcAI-ETpRRRchQhtYNccHGIsPps.lpKclp-.....	0	335	664	843
+12179	PF12345	DUF3641		Protein of unknown function (DUF3641) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF04055. This family consists of proteins which are commonly annotated as Radical SAM domains but there is little annotation to back this up.	21.50	21.50	21.50	24.70	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.86	0.71	-4.31	83	232	2009-09-03 16:04:57	2009-09-03 17:04:57	3	10	220	0	99	252	228	133.40	46	40.40	CHANGED	LPPsQtpLEt-YKctLtpcaGIpFNpLaTITNhPIuRFtphLpppGpapsYhphLpssaNssslpslMCRsplSVsWpGplY..DCDFNQMLslPs.......pspt.hplp-Lhp.ss...ltsppItsusHCYGCTAGsGSSCGGu	...........LPPsQtsLEt-YKcpLtccaGIpFNpLaTITNhPIuRFtphLt........ppsphpsYhphLtssaNssslpslMCRsplSVsWpGpLY..DCDFNQhLslsh...................supt.hplp-lhpts...htsppItsusHCYGCTAGsGSSCGGu....................	0	36	73	93
+12180	PF12346	HJURP_mid	HJURP_repeat;	Holliday junction recognition protein-associated repeat	Coggill P	pcc	manual	Domain	Vertebral Holliday junction recognition proteins carry an SCM3 domain at their N-terminus as do the eukaryotic fungi, but they also carry this central, conserved region. The function of this family is not known. Further downstream there is also a repeated domain, also of unknown function. Investigation of Scm3 and associated proteins is likely to be directly relevant to understanding the mechanism of HJURP-mediated CENP-A chromatin assembly at human centromeres.	25.00	25.00	68.70	48.10	19.10	19.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.46	0.71	-3.96	4	36	2009-09-04 12:32:37	2009-09-04 13:32:37	3	6	24	0	14	39	0	105.50	61	17.80	CHANGED	MSRLLSTKPSSIISTKTFIMQNWNSR+RHRtKSRM..NKTYC+GuR+SQRSuKEsFlPCSEPVK-TGALRDCKNlLDVus+KTGLKLEKAFLEVNKPQIHKLcPSWKELKVTPSKYSS	.MSRLLSoKPSsIISTKT.FIhQNWsSRRRH+pKsRM..N+TaC+Gu+hSpRSu+-s.ssCSEPsKEsGsLRDCcNlLDVSs+K...TGLKLEKAhLEVNKsQlHKLsPoWKELp....shPpK..s..........	0	1	1	1
+12181	PF12347	HJURP_C	HJURP_repeat;	Holliday junction regulator protein family C-terminal repeat	Coggill P	pcc	manual	Domain	Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, Pfam:PF10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.	21.60	21.60	22.10	22.10	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.97	0.72	-4.39	13	404	2009-09-04 15:55:35	2009-09-04 16:55:35	3	7	88	9	135	350	1	63.80	39	14.80	CHANGED	+phs.s..ppsscP-hph...s+sEc+Y+EIcEEFDphaQpYpLust..PtphshsssssVSshpuus	................G....C-SP.-PD.sp.sl....oPpoE-KY+KIsE-hDhhhpch.p.h..ss........lP.....s.N.......F......sMPVolPVos.suh.s............................	0	16	26	59
+12182	PF12348	CLASP_N		CLASP N terminal	Mistry J, Wood V	jm14	Manual	Family	This region is found at the N terminal of CLIP-associated proteins (CLASPs).\	  CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules [1][2].  In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present.  In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1 [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.32	0.70	-5.00	57	1343	2012-10-11 20:01:02	2009-09-07 16:10:40	3	32	291	1	840	1391	6	203.10	18	24.51	CHANGED	l-pphpphhshFpt.+EoEtNWthRppslhplRpll+Gs.sspsh.sshlssl+..th.puIh+shsSLRTolsssuCpLlp-luhhhtsp.l-sh.s-hlh.sLl+hsussKclsupsAshslssllssss..ss+l.hphlhhAhp-KNspsRthustWLphhlp+hs.............pppthptss.....hh....chhccslt+sLsDAsssVR-shRssaWpa..................hphaPs+Acplh..spL-sps++hlc	.....................................................................................t.tp.Wp.+.p....sl.tl....pt..h...h...............tt...........................tt.hh.ttl+.........shht.p.hp.shp..st...ls....ppuh....thl....s.p.Ls....p...t..........h...tp..........p...hcph....sct....ll..s............sLlphh...s..s.....s..p.c.h...lppsuptslpt.lhp...p.....ss......s...pl.....h.thl.ts..s.h...ps.K..s.stlRpp........sht.aLtt.hlpphs.................................h..t...pph........h...........phlht...tl...t...ptlpDsssplRptAppshht.h..........................hp.h..hs.t...............................................................................................................................	0	270	417	646
+12183	PF12349	Sterol-sensing	SREBP-CAP_SSD;	Sterol-sensing domain of SREBP cleavage-activation	Wood V, Coggill P	pcc	Wood V	Family	Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER [1]. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini [2]. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein [4]. WD40 domains are found towards the C-terminus.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.75	0.71	-4.76	34	952	2012-10-02 18:57:54	2009-09-07 17:54:24	3	33	349	0	545	2789	1133	148.90	25	14.06	CHANGED	hlcS+hsLulsGllhlhholssohGhhuhhG..lshohlshpVhPFLlLulGlDNhFlllpuhppsspshs.....cpRlucuLucsGsSlhloulo-hlsFh.lGshoshPAlpsFslaAulAlhhDFhhQlThFsAlLulDh+Rp.tpschchhsphps	..........................................................h..tS+hhL.uluulhhl.hhS...h...hhu.l..u..l.....h.....s...h.....l....G.......ls..hs.h...............l.h.t.ps.l..P.F.......L...l....L...............s..l......G.......l..-...p...h..h.....l.L....s....p....s.......h......h.....p....s.......s...p.p.tph.........................ppp...l...u......c.ulsp...hGso.lhh.s............sls.....ch..ssh.............h....l...G......s...h..o..s.............l..s.u..l..c.tFs......hh..A.uh....sl.lhs.ah.....l...........h.o...h...F.s.u.l.L.o...l.clchp...ttt..........t...............................................................	0	161	245	407
+12184	PF12350	CTK3_C		CTD kinase subunit gamma CTK3 C-terminus	Wood V, Coggill P	pcc	Pfam-B_12814 (release 23.0)	Domain	The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation [1]. The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2 [2]. It is not clear what independent function this C-terminal domain has.	25.00	25.00	33.20	37.90	18.30	18.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.78	0.72	-3.95	31	130	2009-09-09 12:11:31	2009-09-09 13:11:31	3	4	127	0	99	127	0	67.90	39	23.79	CHANGED	lsKppI.hpRhE-DRERHKR.+EshWslst................psEF.cphWschsshs-sp.psshc-hpEhpphspt	.....sK+QI..pRlEEDRERHKRhREshWslstss...........................................psEa.cphW-cso..shs--D.htsh--ht-hpphh..t..................	0	26	54	84
+12185	PF12351	Fig1		Ca2+ regulator and membrane fusion protein Fig1	Mistry J, Wood V	jm14	Manual	Family	During the mating process of yeast cells, two Ca2+ influx pathways become activated. The resulting elevation of cytosolic free Ca2+ activates downstream signaling factors that promote long term survival of unmated cells.  Fig1 is a regulator of the low affinity Ca2+ influx system (LACS) [1], and is also required for efficient membrane fusion during yeast mating [2].	25.00	25.00	25.10	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.38	0.71	-4.40	32	158	2012-10-03 00:20:40	2009-09-10 11:12:12	3	2	113	0	119	187	0	182.80	33	65.11	CHANGED	hhppssss......sstp.lplRsGYhGlClspss..............ss....hhC.....ptshssLsshlp..................ssss.sLNLltlApsFpspllaPhllhssllLshlsFlllsh...............h..lhPh.st...lpphshsluhls..slhhhlushapHhuss.AusshstshohGh...lpuphGspAhshsW..huFsh.lhl.sslulhhhhhp	..................................................................s....ssh...sssp.lplRlGYhGlClpsss......................ushlC.........spsussLup.lp................................spp-.sLNL..lhlAppF+-tlVFPYLl.hs..ulllsh..ls..hllLshhs...................................h..lpPFssp...VsphsLulhhlu..slhhhl.ushWQHsuus.Ausplspshu.Gs....lp.utsGssAhlhuW...huFsh.lll....lslGLhhhhLp......................	0	22	58	98
+12186	PF12352	V-SNARE_C		Snare region anchored in the vesicle membrane C-terminus	Coggill P	pcc	manual	Domain	Within the SNARE proteins interactions in the C-terminal half of the SNARE helix are critical to the driving of membrane fusion; whereas interactions in the N-terminal half of the SNARE domain are important for promoting priming or docking of the vesicle Pfam:PF05008.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.74	0.72	-3.90	20	1258	2012-10-01 21:14:52	2009-09-11 17:34:43	3	20	319	2	844	1215	13	65.10	23	27.89	CHANGED	-tlh+pss+lcsSpRhhsEs.shGtullpsLppQRpsLpssps+lpssssslstosplLpshpRRh	..........................h.cppp.plpp.op.p...hhs-s.p.hGtsshpsLtpQRppLppspp+....lhssss...plstuppllptlp+R.......................	0	290	470	692
+12187	PF12353	eIF3g		Eukaryotic translation initiation factor 3 subunit G 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 130 amino acids in length. The family is found in association with Pfam:PF00076. This family is subunit G of the eukaryotic translation initiation factor 3. Subunit G is required for eIF3 integrity.	22.00	22.00	22.00	22.00	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.80	0.71	-4.22	47	378	2009-09-14 13:49:11	2009-09-14 14:49:11	3	11	284	0	262	367	3	119.60	34	40.69	CHANGED	sPssplhps.sGsKslhpY+hs--GcKlKlspph+..hhpc.+Vs+slAcRKpWsKFGsspsssP.GPsstTT.luE-lhhphspshcppppccppp.......ttpsssshlpCRlC.p.G-HaTs+CPaKsths	........................................s..phhss.p..GhKslhpY+...hs-.-.G.c.......K.lKl.s.+ph+..h.pc.+ls+tVA...c.R+........s.W..sKFGpsptc.s.s.GPs.ss....TT.tl.uE.-lhhp.........hssshcptpppcppp...........httthspphlpCRlC..p..G-HaTs+CPaK-sh.s........................	0	86	144	213
+12188	PF12354	Internalin_N		Bacterial adhesion/invasion protein N terminal	Gavin OL	lg7	Prosite	Domain	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00560, Pfam:PF08191, Pfam:PF09479. There are two completely conserved residues (I and F) that may be functionally important. Internalin mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. This family is the N terminal of internalin, the cap domain of the protein. The cap domain is conserved between different internalin types. The cap domain does not interact with E cadherin, therefore its function is presumably structural: capping the hydrophobic core.	24.10	24.10	24.50	24.30	23.70	24.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.70	0.72	-4.35	32	845	2009-09-14 13:50:09	2009-09-14 14:50:09	3	116	41	39	12	749	0	55.90	39	10.30	CHANGED	h++p.hl+thlhhhLlhhlsh.hlshs.ssclpA.ssIspPsPINpIFPDssLAcsl+p	...........++pshhK.hLlsh.Llhhhul..WIsh.usGscsQA..to...IspPTPINQIFsDsALA-slKs..	0	12	12	12
+12189	PF12355	Dscam_C		Down syndrome cell adhesion molecule C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00047, Pfam:PF07679, Pfam:PF00041. The Down syndrome cell adhesion molecule (Dscam) belongs to a family of cell membrane molecules involved in the differentiation of the nervous system. This is the C terminal cytoplasmic tail region of Dscam.	25.00	25.00	29.90	37.40	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.78	0.71	-3.86	2	83	2009-09-14 13:51:33	2009-09-14 14:51:33	3	25	26	0	21	106	0	122.90	86	5.83	CHANGED	tGuuhass.uPEYDDPANCAPEEDQYGSQY.G.YGtPYDHYGSRGShGRRSlGSARN.PssGSPEPPPPPPRNHD.sNSSFNDSKESNEISEAECDRDphsptNYGsstRu...KDthTTEEMRK	........QGGSLYSGPGPEYDDPANCA....PEEDQYGSQYGGPYGQPY.DHYGS....RGSMGRRSI..GSARN.PG.NGS...........PEPPP.PPPRNH.D...MS......N...SSFNDSKE...SNEISEAECDRDHGPR.GNYGAVKRSPQPKDQRTTEEMRK............	0	7	9	18
+12190	PF12356	DUF3643		Protein of unknown function (DUF3643) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 217 and 4852 amino acids in length. There is a conserved TLA sequence motif.	19.40	19.40	19.70	19.50	17.40	15.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.05	0.71	-4.91	5	94	2009-09-14 13:52:16	2009-09-14 14:52:16	3	6	62	0	49	100	0	143.50	50	4.10	CHANGED	pVApL+coushsaRCs....s.S.hE.sL.sPSPuHlHCVAAILW+SYEL.VpYDLPsLLop-LFEolYcWSMsL-pspPLKKSVDSLLCSLCYI+PcYFohLLsWMGIpLpssus.......phs.TDDsKcpp...ulTDDSKsAp...hsu.h.p.sspshosLlLsESaLsTLAhACQ	..........................lhth+.s..hthhss..............sh..l.PusualHCVAuILW+oach..lpYDLssLLs....p-LFEhLapWohoLssN.......sLKKAlDSLLCShCaI+Ps.hFolLhsWMGIhsP.s.lpsc.....hphShoDDsKcp-.......uhTDDSKssp.........................usLsLo-SpLuTLAuuSQ..................................................	2	10	14	31
+12191	PF12357	PLD_C		Phospholipase D C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00168, Pfam:PF00614. There is a conserved FPD sequence motif.  This family is the C terminal of phospholipase D. PLD is a major plant lipid-degrading enzyme which is involved in signal transduction.	21.30	21.30	23.80	27.40	19.20	18.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.45	0.72	-4.44	66	288	2009-09-14 13:53:00	2009-09-14 14:53:00	3	8	64	0	147	296	0	73.40	46	9.38	CHANGED	l--sFhcPESlECV++VNplA-c.WchYuu--l...s-h.G.HLL+YPlpVspc.GpVssL.PGtEhFPD.stu+llGspo	.....--sFhcPESlECV++VNplA-cpW...chYuu...--l......p-l.G...HLLpYPlpVs.......p-.G.cVstL.PGtEt..FPD.stu+lLGs+.....	0	22	86	118
+12192	PF12358	DUF3644		Protein of unknown function (DUF3644) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 65 and 80 amino acids in length.	21.80	21.80	21.80	22.00	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.46	0.72	-3.71	43	219	2009-09-14 13:53:48	2009-09-14 14:53:48	3	5	217	0	50	180	6	70.60	22	23.26	CHANGED	sl.hhspuWphhL+uhhhpcthc......................hhth.tsGss+shpLppslcp.......s.sps..lt.pNlptLh-hRcp.h	......h.h.ssuaphhh+uhhhpctss...............................hh...ppss.s+shpLppslcc...........scsph.hptsLptlhchRspu......	0	12	31	42
+12193	PF12359	DUF3645		Protein of unknown function (DUF3645) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a conserved HPD sequence motif.	25.00	25.00	27.30	26.20	22.40	17.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.53	0.72	-4.82	27	194	2009-09-14 13:54:36	2009-09-14 14:54:36	3	20	105	0	170	208	11	34.80	53	1.11	CHANGED	ls.sR...phLAVPahuKDsPotpSEFuHPDVlIsLT	...........p.sR......shlAVPacAKDsPStpSEFuHPDVsIlLT..	0	65	114	150
+12194	PF12360	Pax7		Paired box protein 7 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00046, Pfam:PF00292.  Pax7 belongs to a family of genes that encode paired-box-containing transcription factors involved in the control of developmental processes. Pax7 has a distinct role in the specification of myogenic satellite cells.	21.60	21.60	24.10	33.20	19.00	17.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.31	0.72	-3.68	12	179	2009-09-14 13:55:18	2009-09-14 14:55:18	3	6	54	0	53	178	0	44.40	70	9.66	CHANGED	uuuDuuSAYsLuosRHuFSuYSDoFhu.ssusuNtMNP.luNGLSPQ	.....suDoSSAYsLsSsRHuFSSYSDSFhs.PouPSNtMNP.luNGLSPQ.	0	2	8	22
+12195	PF12361	DBP		Duffy-antigen binding protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 449 and 1061 amino acids in length. The family is found in association with Pfam:PF05424. There are two conserved sequence motifs: NKNGG and QKHDF. This family is part of the Duffy-antigen binding protein of Plasmodium spp. This protein is an antigen on these parasites which enable them to invade erythrocytes.	25.00	25.00	274.00	273.10	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.99	0.70	-4.90	4	71	2009-09-14 13:55:58	2009-09-14 14:55:58	3	7	5	0	3	82	0	294.20	88	38.23	CHANGED	SpshhQsVcSSpuE.KVQGDSAHGNlNsGttpSTTscAssGsGQNGNQTPAcSsVpcoDhsEuhSAKNVDspK.VoERusDTsuVTsIsEAGKEsLssopupsSEoTV-ususGDGhVpsAshPVhsSENPLVT.aphht.SKDNSD...ssGS......spssEohAssDSsuK..GEstcsQcstpsKus+DoSspSsuTSu...uoGD....shssl-pt.stusP.pt.......s..VGu.......KctpsE-opspKDutTV..........AGGoTss.pcN...DT-NsNlPsssNKQsEGATALStsESLESNESVH+ThssTTHuLENKNGGsEKDhQKHDFhN	SNPISQPVDSSKAE.KVPGDSTHGNVNSGQDSSTTGKAVTGDGQNGNQTPAESDVQRSDIAESVSAKNVDPQKSVScRSDDTASVTGIAEAGKENLGASNSRPSESTVEANSPGDDTVNSASIPVVSGENPLVTPYNGLRHSKDNSD...SDGP.........AESMANPDSNSK..GETGKGQDNDMAKATKDSSNSSDGTSS...ATGD....TTDAVDREINKGVPEDR.......DKTVGS.......KDGGGEDNSANKDAATVVGEDRIRENSAGGSTNDRSKN...DTEKNGASTPDSKQSEDATALSKTESLESTESGDRTTNDTTNSLENKNGGKEKDLQKHDFKS	0	0	0	1
+12196	PF12362	DUF3646		DNA polymerase III gamma and tau subunits C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00004. The proteins in this family are frequently annotated as the gamma and tau subunits of DNA polymerase III, however there is little accompanying literature to back this up.	23.60	23.60	24.20	25.00	23.00	23.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.25	0.71	-10.10	0.71	-4.15	77	299	2009-09-14 13:56:33	2009-09-14 14:56:33	3	3	296	0	103	270	1082	115.70	35	19.43	CHANGED	sthsoFc..cllpLhpppRDltLtsplcpslRLVpa..pPGRIEhp.sssAspsLsscLuptLppWT.GpRWhVolssp..sGt.PTltEpcpstcpthpscAppcPhVpAlLstFPuAcIs-.lR	................s..hsoap..-lVsLsccpRDhtl+htlcssVRLVph..pPGR..l-lphss..sAPpsLss-Lup+LppWT.Gt.RWsVslu..p-....sGt..TlsEtctttcpphhscAcscP.hVtAlLstFPGA+Ih-VR............................	0	30	66	78
+12197	PF12363	DUF3647		Phage protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 119 and 164 amino acids in length. The proteins in this family are frequently annotated as phage proteins, however there is little accompanying literature to back this up or to describe the nature of these phage proteins.	21.30	21.30	22.30	22.90	21.20	20.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.32	0.71	-3.97	39	387	2009-09-14 13:57:27	2009-09-14 14:57:27	3	1	317	0	24	178	4	110.40	28	83.37	CHANGED	plpIsGK....ph-hKFshtFlpclsKphuh..ptt...t..h....phssGhs.tlhsslhp.tss.slschlcsuhhptppph.opccl-phlcp...h-pp..p.hpclhpcllpcl.ppushhKptscphhp	..............lcINGK....ph-lpFshtFlREl-c+hsh....cst....t..h.....phu.G.ls.tlh.ssLhp.tssssls-lhpsAsut.ppph.oppcI-chl-p.....p....pt...p..lcpLhs-lLpEl.sppshs+thlcph....................	0	8	16	21
+12198	PF12364	DUF3648		Protein of unknown function (DUF3648) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 53 and 3115 amino acids in length. There are two completely conserved residues (A and F) that may be functionally important.	20.60	20.60	22.90	22.90	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.59	0.71	-4.18	9	103	2009-09-14 13:58:36	2009-09-14 14:58:36	3	3	12	0	3	85	0	108.20	64	10.89	CHANGED	hSKltuSahSSuhAssusYohSRhWRphsshtsht.............haGs............sthspll+-hsAshs.sshRco.....lFPaolcAhh+t.sthupshspstpsshshhsl.pspusspPphhsu.shhsLCcPPL..........ossA++ulRpuK	.................MSKLGAsF+SSoFAVRSDYhISRIWRshNTlGVLH.............aFGo............tshTpVlKEaSAshPIVPLRKS.....sFPFSVRAAVRAIcAAu+PhssP+usshsshPVhssuGsspPp.lAGh.RhuLCcPPL................................	0	1	2	3
+12199	PF12365	DUF3649		Protein of unknown function (DUF3649) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length.	21.20	21.20	23.20	23.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.84	0.72	-7.01	0.72	-4.41	39	161	2009-09-14 13:59:17	2009-09-14 14:59:17	3	1	142	0	52	149	2	28.00	39	24.75	CHANGED	sFusRSAhRA.WhGlllsuslLuslhhhs	..sFAsRSAWRA.WhGlhlsuhlLuulshh........	0	11	23	37
+12200	PF12366	Casc1		Cancer susceptibility candidate 1 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 216 and 263 amino acids in length. Casc1 has many SNPs associated with cancer susceptibility.	21.30	21.30	21.80	21.30	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.44	0.70	-4.87	25	204	2009-09-14 13:59:59	2009-09-14 14:59:59	3	4	60	0	109	201	0	216.40	19	39.55	CHANGED	hsp.c.lphsphshph+slphchD+LuhauhuFcphhchs...............hpcWthQ.s.ps..Ellhsl-.....oh+sch.haIo..........spuh+uhspchtKphsu+shKhlcI.cP.p-hppLpcthhscslslFsEp-sphYl-ph.hs...KHluh...E.hshcthslpstlhphhRschs+hs.....s+tsIlL............th+..........ssKs.pcss.sp...........h+loP-sssFlcVo.tss-plslht.shts	...........................................................................................ph.h..hp.shth+hlphchD+lu.h.shu......h..p.h.phs.......................hppaphp...s.pp......phl.hphp........pt.hhphp.hhp........................ttht....t.tt........thsst..c..p.h....c............p.t.L.pthhssshplF.pp-t..hhph...h....cphth...p.hshcphshlGulaphshhchs.ps......t+tphll.............h.................................p.ht.t....t.sh......................hh.hs..s.t...h.s.....hltlT.phspplhhht.shh.....................................................	0	25	32	75
+12201	PF12367	PFO_beta_C		Pyruvate ferredoxin oxidoreductase beta subunit C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF02775. There are two completely conserved residues (A and G) that may be functionally important. PFO is involved in carbon dioxide fixation via a reductive TCA cycle. It forms a heterodimer (alpha/beta). The beta subunit has binding motifs for Fe-S clusters and thiamine pyrophosphate.	21.40	21.40	21.40	21.50	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.45	0.72	-4.05	69	635	2009-09-14 14:37:33	2009-09-14 15:37:33	3	2	596	0	197	390	60	70.40	42	24.41	CHANGED	CVoFNKlNTapWa+E+lhpL...-.saDPoD.+ttAhppuhE....s-p.lPlGllYcsc.+soaE-plshh.....ppsPL	..................................................CVTYNK.lNTYDWF............K...........E+Lsplp...........shE..sY.....D.....s...........o...........D....+p....hA.....h..c......plhE........p-s..LspGllYQsc.ppPoYEpplpth...pcps....................	0	74	139	176
+12202	PF12368	DUF3650		Protein of unknown function (DUF3650) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00581. There is a single completely conserved residue N that may be functionally important.	20.90	20.90	21.70	21.40	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.73	0.72	-6.96	0.72	-4.45	23	786	2009-09-14 15:50:37	2009-09-14 16:50:37	3	2	782	0	48	308	0	27.80	55	8.66	CHANGED	ECRsHPRNRYVpcHsLS-EElpcRLpsl	.ECRsHPRNRYVpcppLoppEhtcRLssl.....	0	13	23	35
+12203	PF12369	GnHR_trans		Gonadotropin hormone receptor transmembrane region 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00560, Pfam:PF00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.	22.10	22.10	22.60	22.10	20.40	21.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.73	0.72	-3.53	14	158	2009-09-14 15:52:14	2009-09-14 16:52:14	3	24	102	0	24	139	0	60.60	56	13.56	CHANGED	+.+.QhotLHPICN+S.h+pD.D-hspspt....pRposh.D..ssaups.s...s......E..a.DYDL.CpEVVsVsCSPc	...........h..p..othpslCNtS...hpp-hs..spspt........pc.ShAEDt..SuYupGFDhhhs.......E..F.DYsL.CNEVVsVsCSPK..	0	1	3	6
+12205	PF12371	DUF3651		Protein of unknown function (DUF3651)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. This family is frequently annotated as a membrane protein but there is little associated literature to back this up.	21.70	21.70	21.90	22.40	21.60	20.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.99	0.72	-3.97	26	305	2009-09-15 14:06:27	2009-09-15 15:06:27	3	5	99	0	183	275	1	75.30	24	8.61	CHANGED	slsFlPp..phGthcuslhlhT.shGs.hhhtl.........pu.uspsPa+L.....pshhthplshssshs..lslaNPaspsLplscl	..........llFlsp..ppGsl-sslhlpT.shGh.hph.V............................................huhssp......pl..........hhlshsss....lslhNstst.ltl.p..............................................	0	32	49	98
+12206	PF12372	DUF3652		Huntingtin protein region 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.	20.90	20.90	21.10	21.30	19.90	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.85	0.72	-4.35	16	142	2009-09-15 14:07:37	2009-09-15 15:07:37	3	5	63	0	66	142	0	41.40	43	2.12	CHANGED	hcslhths+.....lh.chlsGphsuuppsssht......psllpDhhhhp	..u.+tllthPK.....Ih.pLs-GlMASGpcusThAl..sshpsllcDLhVlp....	0	11	13	36
+12207	PF12373	Msg2_C		Major surface glycoprotein 2 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF02349. This family is the C terminal of major surface glycoprotein 2 of virulent bacteria. It is a virulence factor antigen.	25.00	25.00	29.60	28.60	21.50	20.00	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.94	0.72	-7.17	0.72	-4.73	17	82	2009-09-15 14:08:36	2009-09-15 15:08:36	3	7	3	0	0	84	0	29.70	54	3.13	CHANGED	ph+LV+Rsh.....ssstVoEtElKAFDhsA.Ahp	.+ltLV+Ruh.....scsuVoEsElKAFDhsuhAhp.	0	0	0	0
+12208	PF12374	Dmrt1		Double-sex mab3 related transcription factor 1	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with Pfam:PF00751. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.	21.20	21.20	21.60	21.50	21.00	19.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.45	0.72	-3.62	46	292	2009-09-15 15:40:47	2009-09-15 16:40:47	3	4	110	0	38	292	0	63.10	31	39.59	CHANGED	ELGIspPlsL.uus-shVKsEssus.shh...h-.ups.o.s.....ssuSsusssu+.shpssP.uhsuRsas-usSD	.........ELGIspPlsL.suu-hhlKpEssus.sph..hh-..u.......sS.ops..........s.ssssoss..ss....sh..hps.s.uhssph...tt.s............................	0	1	3	18
+12209	PF12375	DUF3653		Phage protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 112 and 194 amino acids in length.	22.20	22.20	22.20	22.30	21.90	20.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.72	0.72	-3.76	20	109	2009-09-15 15:41:35	2009-09-15 16:41:35	3	5	94	0	19	77	0	76.70	28	50.50	CHANGED	GFph.....ptsc.LlTPEG+plpPp-lthhulhhs.Apc.acphhc.ttts............h....................usllthscshh+p+	........GatF..cpu+.LlTPpG+clsstplcshphphs.sRt.acp...hhp.tcts.............th......................h.lhhlt.shhph.h.................................	0	5	13	17
+12210	PF12376	DUF3654		Protein of unknown function (DUF3654) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 193 and 612 amino acids in length.	25.00	25.00	30.80	30.80	23.80	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.72	0.71	-4.35	15	56	2009-09-15 15:42:41	2009-09-15 16:42:41	3	2	7	0	27	53	0	127.60	42	32.99	CHANGED	IpphPusLScEEK++ccchLppIKEYGEpLsTcEKQ-cIlcAQKIlCDACc.IWt+.cE-RhthlhttaSp+LpLKhhtus....sch.chchsLhthlDHchLlsAacEYt.hDVsuELV+QhhL..csc-IDcc.lscs...V	..........t.ssthsp-E+ch..c.hpphKcaGtpLpspE+hcpIlEsEKIVCsAC+cIChsL+EEELhGLhAEGuh+KsLKtph.u-......cchpcttY.....LEhthlDpplLLDAH.+EaG.t-Vs+ELV+QhLLGKcG+-ID++Yls+VAssV............	0	27	27	27
+12211	PF12377	DuffyBP_N		Duffy binding protein N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF05424. This family contains the N terminus of the Duffy receptor binding domain.	25.00	25.00	28.70	73.30	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.99	0.72	-3.76	3	77	2009-09-15 15:43:41	2009-09-15 16:43:41	3	6	5	0	3	84	0	61.50	92	9.21	CHANGED	cEEKDGEHKTDSKTDNGEGsNNLVMLDYDTSSNGHPAGTlDNVLEFVTEHEGNSLcNSSKGGN.PYD	...........GEEKDGEHKTDSKTDNGKGANNLVMLDYETSSNGQPAGTLDNVLEFVTGHEGNSRKNSSNGGN.PYD	0	0	0	1
+12212	PF12378	CytadhesinP1		Trypsin-sensitive surface-exposed protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 67 and 79 amino acids in length. This family contains trypsin-sensitive surface-exposed proteins called cytadhesins. Cytadhesins are virulence factor proteins which mediate attachment of bacterial cells to host cells for invasion.	25.00	25.00	25.10	31.60	23.50	22.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.01	0.72	-4.03	8	115	2009-09-15 15:45:13	2009-09-15 16:45:13	3	3	12	0	13	113	0	70.30	42	13.09	CHANGED	hpoTshas.ct+PsW.........NshsGFssssoppptpu.pcps-..sSuPIuLPa-sYhsNlGNlhhhspuVllFGGN	...oTsphs.stcPpa.........NshsGFGlsGs.....uPpcasE..cupsPlpls.psa.sNlhsllhlspsVlhatt......	0	11	11	11
+12213	PF12379	DUF3655		Protein of unknown function (DUF3655) 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF08716, Pfam:PF01661, Pfam:PF05409, Pfam:PF06471, Pfam:PF08717, Pfam:PF06478, Pfam:PF09401, Pfam:PF06460, Pfam:PF08715, Pfam:PF08710.	25.00	25.00	56.30	55.20	24.80	23.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.47	0.72	-4.05	3	173	2009-09-15 15:46:42	2009-09-15 16:46:42	3	5	67	2	0	150	0	68.80	93	1.17	CHANGED	MYCSFYPPDEEEDCEEYE-EEElsEETCEHEYGTEDDYKGLPLEFGASTEIlQVEEEEEEDWLDDAlEAc	MYCSFYPPDEEEE.DDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVE.EE.EEEDWLDDTTEQS.....	0	0	0	0
+12214	PF12380	Peptidase_C62		Gill-associated viral 3C-like peptidase	Coggill P	pcc	MEROPS_C62.001	Family	a positive-stranded RNA virus of prawns, that has been called yellow head virus protease and gill-associated virus 3C-like peptidase. The GAV cysteine protease is predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, pp1a and pp1ab. This protease employs a Cys(2968)-His(2879) catalytic dyad.	18.80	18.80	19.60	643.90	18.20	18.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.85	0.70	-5.58	2	13	2012-10-02 13:45:52	2009-09-15 16:57:05	3	3	2	0	0	15	0	284.00	95	6.70	CHANGED	FLVGLVTHEVpTGNsTpVEDLNKHPYNKYRpNIVRVYGERGDLNGFLSGK.LaFPRHIFDoCTDNTLTRHIRVTKGEtTHDIELLSEEYDATPFIKs-SPFAEAT.LKFuKLQRTQasYFVTADDIRlGSMSsDGYHNISTKDGDCGSllFDHLtNVVGAHIVGIusIPPVNGALTWNsEpEhLCGPNsDYDaDPpKVsPPKVWPVEslTALSTlLNQLNYVTGDAFTTPKLPTNYQLlGCETLDQYVNApNLVTGQFPQIKEALDDFINGYVANLQRGsEAYN	FLVGLVTHEVNTGNNTRVEDLNKHPYNKYRSNIVRVYGERGDLNGFLSGKFLYFPRHIFDSCTDNTLTRHIRVTKGEETHDIELLSEEYDATPFIKI-SPFAEATVLKFGKLQRTQYAYFVTADDIRVGSMSsDGYHNISTKDGDCGSLLFDHLHNVVGAHIVGIASIPPVNGALTWNAEKEMLCGPNDDYDYDPEKVGPPKVWPVESITALSTILNQLNYVTGDAFTTPKLPTNYQLIGCETLDQYVNARNLVTGQFPQIKEALDDFINGYVANLQRGTEAYN	0	0	0	0
+12215	PF12381	Peptidase_C3G		Tungro spherical virus-type peptidase	Coggill P	pcc	MEROPS_C03.024	Family	This is the protease for self-cleavage of the positive single-stranded polyproteins of a number of plant viral genomes. The protease activity of the polyprotein is at the C-terminal end, adjacent to the putative RNA polymerase.	20.70	20.70	22.20	21.20	20.10	19.30	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.40	0.70	-5.11	3	29	2012-10-02 13:45:52	2009-09-15 16:57:36	3	4	11	0	0	48	0	225.10	36	9.79	CHANGED	cKGLDKDPNMVoILos+LssISCVIlNlTPsRpAYhNVlRLCGTaVVCPAHYLEALEE-DTLYFICFSllIKLpF-PcRVTLVNoaQDLVVWDLGNSVPPSIDsLcMIPTl-DWD+FQDGPGAFuVTKYNu+aPTNYINTLDMIERIRANTQNPTGhYcMhGSpHTITTGLRYQMaSL-GFCGGLILRAsTsMVRKIVGlHVAGSpNHAMGYAECLlQEDL+pAIs+LuhD	..........................................h......D.sh.pLlss+.hssh.pl.hlst.ssh.h.hhsGLFlpushhLhPuHhlsh.lsppcp..I...hh.h..c..sl..h+....V.h.cs.+K.V.slV.N.....u.......p.Esslhsh.s.p.Vst+pDllc.aFtsu-shspa+t..s.ps...sLssh+a...Stc..s.spalps.L.ts-+h..-A.....D+Phohs-sppGpYhlRQGLEYphsohsGDCGuPllls-opshRKIsGlHVAGhst..p...u...+..uYAEoITQcDLhpAhppl...sso..................	0	0	0	0
+12216	PF12382	Peptidase_A2E		Retrotransposon peptidase	Coggill P	pcc	MEROPS_A02.051	Family	This is a small family of fungal retroviral aspartyl peptidases.	21.10	21.10	21.60	22.40	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.47	0.71	-4.37	2	4	2012-10-02 15:32:34	2009-09-15 16:58:21	3	1	2	0	3	7	0	137.00	90	10.28	CHANGED	KpNsTpsRp.+KTNVSRIEYSSppFhpap++RYEMVLQAcLP-FKCSIPCLIDTGAQsNlITEETVRAHKLPTRPW.pSVIYGGVYPsKINRKThKL.IsLNGISIKTEFLVVKKFSHPAAISFTTLYDNNIEISSS	........................KNNTTNSRNLRKTNVSRIEYSSNKFLNHTRKRYEMVLQAELPDFK.CSIPCLIDTGAQANIITEETVRAHKLPTRPWSKSVIYGGVYPNKINRKTIKLNISLNGISIKTEFLVVKKFSHPAAISFTTLYDNNIEISSS..............................	0	3	3	3
+12217	PF12383	SARS_3b		Severe acute respiratory syndrome coronavirus 3b protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 32 and 154 amino acids in length. This family contains the SARS coronavirus 3b protein which is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells.	25.00	25.00	59.30	59.30	18.50	18.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.11	0.71	-4.29	3	70	2009-09-15 16:01:23	2009-09-15 17:01:23	3	1	66	0	0	16	0	118.70	96	99.22	CHANGED	MMPTTLFAGTHITMTTVYHITVSQIQLSLLKVTAFQHQNSKKTTKLVVILRIGTQVLKTMSLYMAISPKFTTSLSLHKLLQTLVLKMLHSSSLTSLLKTHRMCKYTQSTALQELLIQQWIQFMMSRRRLLACLCKHKKVSTNLCTHSFRKKQV	MMPTTLFAGTHITMTTVYHITVSQIQLSLLKVTAFQHQNSKKTTKLVVILRIGTQVLKTMSLYMAISPKFTTSLSLHKLLQTLVLKMLHSSSLTSLLKTHRMCKYTQSTALQELLIQQWIQFMMSRRRLLACLCKHKKVSTNLCTHSFRKKQV	0	0	0	0
+12218	PF12384	Peptidase_A2B		Ty3 transposon peptidase	Coggill P	pcc	MEROPS_A02.022	Family	Ty3 is a gypsy-type, retrovirus-like, element found in the budding yeast. The Ty3 aspartyl protease is required for processing of the viral polyprotein into its mature species.	21.20	21.20	21.40	21.20	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.05	0.71	-4.94	2	18	2012-10-02 15:32:34	2009-09-15 17:03:42	3	6	11	0	13	32	0	140.50	27	17.31	CHANGED	VLsDhELESKDpppL.IpohPIVHYIAIPEMDpTAEKpIKIpNTKlKTLFDSGSPTSFIRRDhVpLLph.ha-TPPLRFRGFluTcSssTSEAVTlDLplssLQIslAAYlLDpMDYQLLIGNPILRRYPKlLaTlLNT+psssu.KPKsY+SEsVN.V+shSAGNRGNsRNhp.SF	...................t........................ll..h....htpsh.hplphpssplcs.LhDoGSPTSFIRpDllpcLcLphapsPshch+...Ghlus.p.st.ospAsplslphsshphslsAYVh-t..hchpllIG.PhLc+aPpl.........h.s.hhp................................................................................	0	3	6	13
+12219	PF12385	Peptidase_C70		Papain-like cysteine protease AvrRpt2	Coggill P	pcc	MEROPS_C70.001	Family	This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis [2]. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2 [1].	18.80	18.80	18.80	18.80	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.07	0.71	-4.55	4	20	2012-10-10 12:56:15	2009-09-16 12:43:07	3	5	19	0	6	44	0	158.90	28	25.46	CHANGED	sPhhGGhF.........-ouGSSuopuuSphh.............VPYlsQtspR.GCWYAsspMlua.hpsGP..RLGLPtLY-u.pG.PptLpt.pDl.chh+sEsLtplslPsscpaos-cLuALLscHGPIhhu...hcoP..sDsh..Hh.VLTGID+.sssIpaHDPctGPshsMsLshhNpthsWp.sH	...................................................s................................................h.Qpspt..uCWhAsssMlhtahc...s.....t..s..........+lG.s.L..Ycu.p...G.hPtthpt...p-h..........tchhpstuL.ps.ls.P.......tsps....aospphtsLLpcaGPlhhu...hcoP..uss.a....HshVl..TGIcp...-...s......c..ul.hhDP.....pG.p.h...shp.h..spt....................................	0	1	2	4
+12220	PF12386	Peptidase_C71		Pseudomurein endo-isopeptidase Pei	Coggill P	pcc	MEROPS_C71.001	Family	This peptidase has the catalytic triad C-H-D at the C-terminal end, a triad similar to that in thiol proteases and animal transglutaminases. It catalyses the in vitro lysis of M. marburgensis cells under reducing conditions and exhibits characteristics of metal-activated peptidases.	20.80	20.80	20.80	22.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.09	0.71	-4.75	3	4	2012-10-10 12:56:15	2009-09-16 12:58:37	3	2	4	0	1	24	6	145.50	33	55.48	CHANGED	ssssc-TT-l.....p-KlGsF+DATSLYs+V++RCKYKYYYNDQsPN+EAlpKMsT.sGINCTDACQLFp+VlEuLGYsV+IEHVRVRCNDGKWYGHYhLRVuGpELss.......GTlWDY..VSATKTGRPLGuPCCosGh...QHLGWGIVSPlYD	...................s..hsp.spch.....hchh.Gthp.shsphhshlp+RptYpaYYNsQhss+cslp+hhs.pGlNCTDusQLFh+lhcuLGYsVph.HV+.sR...ssGp..GHhh..LR..l..ttp.chs...........GssW.Y..suAstsGps..luushCpsGh....c.uW.IhoslYp..................................	0	0	1	1
+12221	PF12387	Peptidase_C74		Pestivirus NS2 peptidase	Coggill P	pcc	MEROPS_C74.001	Family	The pestivirus NS2 peptidase is responsible for single cleavage between NS2 and NS3 of the bovine viral diarrhea virus polyprotein, a cleavage that is correlated with cytopathogenicity [1]. The peptidase is activated by its interaction with 'J-domain protein interacting with viral protein' - Jiv. [2, 1].	20.90	20.90	20.90	79.00	17.90	20.10	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.23	0.71	-5.15	6	178	2009-09-16 12:02:53	2009-09-16 13:02:53	3	22	28	0	0	196	0	181.60	71	6.17	CHANGED	WLG+lsYKRVsoVY-lDpStEGVYLFPS+QKssutsuhlLPLL+AlLISCISSpWQhhYLhYLllElsYYhHRKIIEEIAGGTNhlSRLlAALIElNWuhD-EEoKGLKKFFlLSuRV+NLIlKHKVRNEsls+WatEEElYGMPKllollKAATLSKsKHCILCTVCEsR-WKGssCPKCGRpG.PIoCGMTLADFEE+	...............WLhthsYKplssl.Y-lDpuGEGVYLFPS+QKssp.huhhLPLl+AhLISCISsKWQhlYhhYLhh-h.YYhH+KlI-EIuGGTNhlSRllAALIElNWuh-pEEsKGLKKFaLLSuRl+pLIIKHKVRNEsVspWaG-EElYGMPKllolIKAuTLSKNKHCIlCTVCEuR-W..+Gus..CPKCGRaG+PITCGMTLADFEE+.	2	0	0	0
+12222	PF12388	Peptidase_M57		Dual-action HEIGH metallo-peptidase	Coggill P	pcc	MEROPS_M57.001	Family	The catalytic triad for this family of proteases is HE-H-H, which in many members is in the sequence motif HEIGH.	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.37	0.70	-5.00	5	69	2012-10-03 04:41:15	2009-09-16 14:03:59	3	10	40	0	35	188	15	198.00	31	60.86	CHANGED	IhIEuDIshTcKELNcLp..u.ss-sKQYRTsNLVssusRTITIlGYTGssQ.uLoupupTALscAVNNYNsl.GhsIsF.RLTFGTNaQNuDMVVYsNolNNPSGo....GGuAGFPsusGcPsKFVQI....YsLcssSTNVsEH.VITHEIGHSIGFRHTDYasRp.SC..GpsGNEGoGGlGAVaIPGTPTGpDsoSlMQACFSsGsDGsFNoNDITALLsMY	........................................................................................................lttDhhho.pt.pp...h............t.........s.....t..cQYRTsslV.....s.t.s.p....sI.slhs.s.............uhs.s.p.hpsuLpp....AlspYNsl..sLslsF...pht.h.....ss.s....h.t....s.t.sh..s..l.h..p.s.sss...sGs.....G..us..A.G.F.P........o..s..Gp..P.....a....p..h.lpI...........h.u.h..s....s....h....s....s....s....s..h..p+....VlsHElGHslGhRH.T.D....ahs.Rp...SC....Gps..s.sEGsu...ssGAltIPGTPos...h..s..s.sSlM.u.Chss.s..psstFsssDhhALphhY.......................................................	0	14	22	31
+12223	PF12389	Peptidase_M73		Camelysin metallo-endopeptidase	Coggill P	pcc	MEROPS_M73.001	Family	\N	21.40	21.40	21.40	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.35	0.71	-4.85	2	432	2009-09-16 15:08:38	2009-09-16 16:08:38	3	3	167	0	49	281	4	171.20	43	87.42	CHANGED	M..oLKKKLGMGlASAsLGhuLlGGGTFAaFSDKEVSNNTFAsGTLDLsLsPpTlVslpsLKPGDoVcKEFhLcNpGoLsIKcVhLtTcYsVcDVKtDNt.-DFGKHlKVpFLhNhDKppp.VhETsLscLptss.shlspDlhA..WsEK.GlpAGppDhhhVpFEFVDstKDQN.FQGDpLpLpWTFsApQtsGEpK	.................M...olKKKLGMGlsoAs.L...Glu..L.l..GG...GTaAaF..S.Dp.E.s.S.s.N..TFAAGT..LDL.sl.................s...P....p.....s.....l.....l..s.............l.........p.........sL..K.......PGDpl.cK.pFpLpN.pGo.Ls.I.c.cV.hL..tTcY...s.V....pD..sK...t..s..N.t.........-DFGcHlcV.pFLh..Nh......D..K...........p......p......p.l..hpTT..Ls...cLpt..s.p...h...h..tp....cl......t......h..t.E.t....G.ltsGpp.DhhhV.FpF...DstpD......Q.......N.FQGDpLpLpWTFpu.QttGpp+...................................................................................................	1	12	34	41
+12224	PF12390	Se-cys_synth_N		Selenocysteine synthase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF03841.  There is a single completely conserved residue P that may be functionally important. This family is the N terminal region of selenocysteine synthase which catalyses the conversion of seryl-tRNA(Sec) into selenocysteyl-tRNA(Sec).	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.68	0.72	-3.86	134	925	2009-09-16 15:44:25	2009-09-16 16:44:25	3	5	916	0	183	611	49	39.90	44	8.67	CHANGED	hRplPulDplLppsthtsh......................lpphuRshVhcslRphl-phR	...appLPulD+LL+-s..shhsL......................h-pYG+otVl-hLRphLDcAR.................	0	66	115	155
+12225	PF12391	PCDO_beta_N		Protocatechuate 3,4-dioxygenase beta subunit N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00775.  There are two completely conserved residues (Y and R) that may be functionally important. This family is the N terminal region of the beta subunit of protocatechuate 3,4-dioxidase. This enzyme utilizes a mononuclear, non-heme Fe3+ centre to catalyse metabolic cellular reactions.	21.60	21.60	21.90	24.20	19.80	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.66	0.72	-4.52	79	491	2009-09-16 15:49:27	2009-09-16 16:49:27	3	3	474	172	150	420	62	35.90	41	14.71	CHANGED	ahtRDtsh.HPPthtPsY+oSlhRuPppsLlsl....ssol	...............tRDhsh.HP.sthsPsYKoSVLRuPppsLlul...ppo.........	0	29	77	115
+12226	PF12392	DUF3656		Collagenase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF01136.	22.10	22.10	22.60	22.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.29	0.71	-4.05	199	1248	2009-09-16 15:51:28	2009-09-16 16:51:28	3	4	1215	0	283	989	60	120.40	32	17.09	CHANGED	la.+spDpphtcpl.cp..........stp++lslph.plp..hc.....hsps........hplplp..............s.tp.u...h.....psp..........................sps....shshptApppshsp-plccpLu+lGsTsFph..............pp..lplp.h..............stshFlPsStLNplRRcul-pLppthhtsh	..................................................................................................................RshDpphpptL.+p..........sucR+lsVcl..pls......t........ht-t...............LhLols................s...-c.G....s.......slo..............................................h.s.h....-.s...h-pApssths....hssL....cctLu.KLGpT..ahs..............cc..lpls...l..............ss.slFlPsShLNphRR-Al-hLctsRltt................	0	108	198	246
+12227	PF12393	Dr_adhesin		Dr family adhesin 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF04619. This family is the Dr-family adhesin expressed by uropathogenic E. coli.	25.00	25.00	28.00	28.00	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.39	0.73	-6.50	0.73	-3.65	5	56	2009-09-16 15:52:41	2009-09-16 16:52:41	3	1	2	0	0	56	0	21.00	67	13.14	CHANGED	MKKLAIMAAsSslhssSTAHA	MKKLAIMAAsShlhAsSoAHA	0	0	0	0
+12228	PF12394	DUF3657		Protein of unknown function (DUF3657) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF05057.	21.80	21.80	22.40	22.70	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.98	0.72	-3.90	39	350	2009-09-16 15:53:31	2009-09-16 16:53:31	3	8	98	0	200	384	1	62.30	29	8.76	CHANGED	lpl-Lhas-hhpssp.............................hptlustshpl..pstptl+ca.sslhF......DhhHhshlss.slassll	............................lpLhasph.psss.................................................hhus+sLtlp.+hphG...l++a.sslhF......Dh.Hhshlul.slatsLh......	0	52	75	126
+12229	PF12395	DUF3658		Protein of unknown function 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF08874. There are two completely conserved residues (D and R) that may be functionally important.	20.60	20.60	22.30	22.10	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.13	0.72	-4.51	40	322	2009-09-16 15:54:13	2009-09-16 16:54:13	3	3	272	0	72	276	16	110.90	28	38.04	CHANGED	lhcthpptp.lo.pctppLtpEWpplpppsu.LRlWcss.plpSspc.saaDshIlc.........psss-atpus+llGplhup....h...pph.lu......DsFltaRl+pLlppGhlchcGsht.shcphpl	.....................h..tth.tht.lostchtphttEWpplpppss.LRlWpss.plpSs.pc.shaDphIlc..........ts.s.p-ahp..AscllGpshut....s.......cth...lu......DsaltaRl+pLlppGhl-hpGshs.thp.hp............................	0	20	41	54
+12230	PF12396	DUF3659		Protein of unknown function (DUF3659) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 70 amino acids in length.	22.10	22.10	22.20	22.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.23	0.72	-4.30	116	553	2009-09-16 15:55:19	2009-09-16 16:55:19	3	17	61	0	480	572	2	65.10	35	43.00	CHANGED	husLcG.hpVs+tGpllD.ssGpslG+llEG..Dscc...Ls..G+p...V.D-cGcIlDcsGsllG+sEhl..s........pptp	.........ssLpG.hpVs+sGpVlD.psGphlG+llEG....Dscc...Ls.....G+p.......l.D-cGcllDc.sGsllG+sEhl.t....tt..p............	0	80	213	374
+12231	PF12397	U3snoRNP10		U3 small nucleolar RNA-associated protein 10 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF08146. This family is the protein associated with U3 snoRNA which is involved in the processing of pre-rRNA.	22.00	22.00	22.00	24.40	20.80	21.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.48	0.71	-4.16	67	281	2009-09-16 15:56:45	2009-09-16 16:56:45	3	8	238	0	201	271	1	121.50	21	6.72	CHANGED	-shl.plL.Phl.cult.ppss........DhphuuYhllshLus+ssLsspllpuLhcslspshptpst........pp..............uLhsLs..............hlh.....ppp.sstp.............lsppshctlhph.s.....hsphLspl.spphpl..sphlhslltuh.l	...............................sllspllPhltcuLp.sphs........-hphusYMlls.Lus+ssLpcsllsuLhcplhpshsppst..........ps..............uLhs.Lh..............hLh............Qpp..p.sp.p................Lspcshpt.Lh..ph.s.......lhshLppl.upphsl....sphltshh.sh........................................................................	0	62	106	165
+12232	PF12398	DUF3660		Receptor serine/threonine kinase 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00954, Pfam:PF01453, Pfam:PF00069, Pfam:PF08276. There is a conserved ELPL sequence motif.	25.00	25.00	27.20	26.10	23.60	22.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.94	0.72	-4.09	34	150	2009-09-16 15:59:03	2009-09-16 16:59:03	3	12	24	0	15	168	0	41.50	50	5.90	CHANGED	ussIs..ppRsQsLl.MNthVl....SS++p...lS.tEN+o.E-LELPLhEa	......ATsIss.ppRsQsLl.MN.....thVl....SS+Rp...lS.tEN+s.E-LELPLhEh.	0	4	8	10
+12233	PF12399	BCA_ABC_TP_C		Branched-chain amino acid ATP-binding cassette transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00005. There is a conserved AYLG sequence motif. This family is the C terminal of an ATP dependent branched-chain amino acid transporter.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.19	0.72	-6.41	0.72	-4.21	827	8057	2009-09-16 16:01:50	2009-09-16 17:01:50	3	14	2852	0	2574	6299	2877	22.90	46	7.99	CHANGED	chIAcGsPp-lpssPcVlcAYL.G	........llAcGoPp-lpssscVhcAYLG.....	0	633	1531	2091
+12234	PF12400	DUF3661		Vaculolar membrane protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 123 and 138 amino acids in length.	22.00	22.00	25.00	24.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.85	0.71	-4.05	49	275	2009-09-16 16:04:10	2009-09-16 17:04:10	3	5	208	0	206	258	1	124.00	35	39.14	CHANGED	CsaYhlNlllDo...TlGlhllah....hlphlsplhph....hthpplc.SGpY.....................................t.PphpsahpQhhlYhhslhhhKhhlhllhhhh....hlthluphlLsa..hcttsp.lplhhVMhlhPllhNslQaallDshI+pp	.....................................................................CshYhlNhllDs........TlGl.llal....hl+hlstlsph.................thp..s.....lc..GpY.................................................................................GsPPpstsWltQshlYhhhlhhhKhslhlllhhh....hhtpluphlLsa..hc...s..Pp.lplhhVMllhPhlhNslpaallDshlpp.....................	0	66	107	164
+12235	PF12401	DUF3662		Protein of unknown function (DUF2662) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00498.	25.00	25.00	27.90	27.50	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.26	0.71	-3.93	76	515	2009-09-16 16:04:50	2009-09-16 17:04:50	3	3	496	1	146	383	83	114.90	32	36.99	CHANGED	Ls+hEptlEphlpusFu+sFpup..lpPsElsptLcREh-spsthluts+hl.sPNtaslpLussDacplss...h.tssLspElsshlpcaupppsashs.GslpVphpp..sssLcsG.pa+lpu	.............lp+hE+plEssVsssFA+sFp.up..lpPsElsutLpREh-spsphlups.+sl..sPNcahlpLSspDa-+Lssh...sctLssEluspLpcaspcptashh..GslhVca-t..sssLpsG.paclp.............	0	54	113	138
+12236	PF12402	nlz1		NocA-like zinc-finger protein 1	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 42 and 57 amino acids in length. There is a conserved GAY sequence motif.  There is a single completely conserved residue G that may be functionally important. Nlz1 self-associated via its C terminus, interacted with Nlz2, and bound to histone deacetylases.	21.20	21.20	26.30	24.40	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.77	0.72	-3.62	7	173	2009-09-16 16:05:48	2009-09-16 17:05:48	3	2	89	0	44	126	0	51.50	68	10.89	CHANGED	AuhsYPGSlsGAYAGYPppals...uLDssK..uSLVuuQh.....uohGss.K.suuushsG	...AGMoYPGSLAGAYAGYPppFLPHG.shD.tK..uSL.VsAQL....AuSLGC.S....AGSSPLAG.....	0	3	7	18
+12237	PF12403	Pax2_C		Paired-box protein 2 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.	28.10	28.10	42.50	29.80	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.73	0.71	-4.43	11	295	2009-09-16 16:06:57	2009-09-16 17:06:57	3	5	51	0	109	199	0	101.30	53	28.58	CHANGED	suspsssshsuhuchusshuphpS.slhsGR-hu.STTLPGYPPHVPPTGQGSYsoSoLAGMV.PGu-FSGNPYSHPQYooYNEAWRFoNPuLLuSPYYYSsAuRss.PPTuATAYD+	...............................st......s.sssschGushst.p.oh.sl....loGRDMA..STT...LPGYPPHVPP...oGQGSYso.SoLu.G...MV..PGS-FSGsPYSHPQYoo.Ys-u....W...RFs.NP..u..LLu.SPYY..YSussRsuss....sssAs..AaD............................................	0	5	11	57
+12238	PF12404	DUF3663		Peptidase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00883. There is a conserved WAF sequence motif.	25.00	25.00	33.40	31.60	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.62	0.72	-4.20	55	805	2009-09-16 16:07:38	2009-09-16 17:07:38	3	3	792	0	98	412	11	76.90	63	18.01	CHANGED	MplpLSppsAsupWGcpAllSFsssuAsIH.....L....ssscsLppIQ+AARKLcuQGIppVpLsG-sWcLEppWAFhQGFtss	..M+ITLSTQPADARWGEKAshShNs.DGlTlHL.....NGsDD..LGLIQRAARKIDG.GIKpVpLoGEGWDh-+CWAFWQGY+uP..	0	9	32	66
+12240	PF12406	DUF3664		Surface protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 131 and 312 amino acids in length.	23.00	23.00	23.50	121.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.71	0.72	-3.40	5	53	2009-09-16 16:09:15	2009-09-16 17:09:15	3	3	4	0	1	50	0	100.20	81	54.80	CHANGED	DRQLNPIDFDPNDDQQPLDPNQLIDQtEQSQEPTQQEPIEPQQPTQPuT.EPEELEPETVTVEVP.EPVTSEE...PKE.........SoQTEEsTETQDsKpE.PTpQPVDEPP	DRQLNPIDFDPNDDQQPLDPNQLhDQhEQS....QEs....TQQEPIEPQQPTQPST.EPEEL-PETVTVEVP.EPVTSEE...PKE............SDQTEE.QKHEEPEAS.PsPEPVDEPs	0	0	1	1
+12241	PF12407	Abdominal-A		Homeobox protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00046. This family is a homeobox protein involved in differentiation of embryonic cells to form the abdominal region.	25.00	25.00	26.20	33.70	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.06	0.72	-4.42	5	126	2009-09-17 12:02:55	2009-09-17 13:02:55	3	2	103	0	24	91	0	23.90	83	12.42	CHANGED	ELRAVKEINEQARREuc..EcE+c++	.ELRAVKEINEQARRERE...EQDhMK+........	0	8	11	21
+12242	PF12408	DUF3666		Ribose-5-phosphate isomerase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF02502. There are two completely conserved residues (D and F) that may be functionally important.	25.00	25.00	31.10	30.20	21.00	16.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.34	0.72	-4.86	37	553	2009-09-17 12:03:37	2009-09-17 13:03:37	3	2	544	19	66	225	3	48.30	52	22.79	CHANGED	sssh+.shlssL+slDQ-LlKsAluGc+FQ-hFFsNCpspcIssYV+sl	....thsh+.shlshL+sID.-hlKsslSGt+FQchFFENCQ-cEltAal+pl..	0	14	33	52
+12243	PF12409	P5-ATPase	P_ATPase;	P5-type ATPase cation transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with Pfam:PF00122, Pfam:PF00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.	21.70	21.70	21.90	24.20	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.38	0.71	-4.25	66	485	2009-11-19 17:32:02	2009-09-17 13:04:37	3	23	233	0	321	463	0	118.50	21	10.19	CHANGED	-D..hhl.sIsGY+sshh+..hhlahhhslhThGlhaLlh+WhP+a+lphhsptssLtcA-..aVl..lE..........spas...phplhpVpp.....phascshSshhs.spp...................h.hspppss....tlsplRhhpYR	..........-.ph.plhGYcpshh+..hhlhhhhslhohG......lhh.L.lh+WhP.cWpVphpsp...s.....s.Lpc.A-.....hVl..lp......................................spap...............phhh.tpVpp................h.h.sp....th....t..........................................................................................................................	0	115	158	251
+12244	PF12410	rpo30_N		Poxvirus DNA dependent RNA polymerase 30kDa subunit 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 193 and 259 amino acids in length. The family is found in association with Pfam:PF01096. There are two conserved sequence motifs: GIEYSKD and LRY. This family is N terminal of the 30 kDa subunit of poxvirus DNA-d-RNA-pol. It has structural similarity to the eukaryotic transcriptional elongation factor SII.	25.00	25.00	53.40	52.80	21.10	19.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.51	12	114	2009-09-17 12:05:32	2009-09-17 13:05:32	3	2	83	0	0	76	0	133.60	70	60.24	CHANGED	pDlccllp+YVs-pscspcLlpWAp-pAs+aYl+NIsNTK.SNIEETKF-PtNNIGIEYSKDsKNKLSYRNKP.It..TNh-YpDlCshI+sTNGsEK-hLRYlLFGIKCl+tGVEYsIDclpDhsY.ccYFNVLDcKaN	...DIc-llh+YVc-.uplc-llcWAh-KuSKaYI+NIhNTK.SNIEETKFEs+NNIGIEYSKDSKNKLSYRNKP.Is..TNh-Yp-lCshI+sTsGTEKEhLRYlLFGIKClpKsVEYNIDcI+DlsY.p-YFNVLDcKYN.	0	0	0	0
+12245	PF12411	Choline_sulf_C		Choline sulfatase enzyme C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00884. There are two completely conserved residues (R and W) that may be functionally important. This family is the C terminal of choline sulfatase, the enzyme responsible for catalysing the conversion of choline-O-sulfate and, at a lower rate, phosphorylcholine, into choline.	21.30	21.30	29.60	24.20	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.74	0.72	-4.14	37	292	2009-09-17 12:09:02	2009-09-17 13:09:02	3	6	284	0	123	283	111	54.00	51	10.51	CHANGED	cpcVlpSQpRR+lVas......AL..ppGphtsWDaQPh.pDuSppYhRNHhc..LsslEttuRa	...cppVltSQRRRRlVap......AL..pp..Gpht.sWDaQPh.pDASpcYMRNHh-..LDsLEppuRF..........	0	18	54	88
+12246	PF12412	DUF3667		Protein of unknown function (DUF3667)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. There is a single completely conserved residue P that may be functionally important.	21.80	21.80	21.80	21.80	21.50	19.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.99	0.72	-4.65	78	186	2009-09-17 12:10:03	2009-09-17 13:10:03	3	5	129	0	78	203	27	46.20	33	13.02	CHANGED	Du.+hh+TlhtLhh+PGplsccYlsGc..Rt+YlsPhphalhsuhlh........Fl	...Dsphh+TlhtLlh+PGplsccYlsG+..RhcYhsPhphalh.huhlhh..........	0	39	65	76
+12247	PF12413	DLL_N		Homeobox protein distal-less-like N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.	25.00	25.00	26.50	25.60	23.50	22.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.41	0.72	-2.94	20	283	2009-09-17 12:10:48	2009-09-17 13:10:48	3	2	148	0	84	168	0	74.10	45	33.67	CHANGED	p-SPTLPESTATDsG.YYSspts......HsYhss.....psY.upslN.sY.......Qa.phsGlsus.usYu.sK.sYs....Y.suuY...+QY.GsYsRssssssps	.....p-SPTLP.SosTD.s..YYss..........tasuu......uPY..tpls.sY........QY.phsuhuu.........ssYs.AK..uYs.h...a.suoY...t.pY.GuYupssSsss..s.............	0	4	11	37
+12248	PF12414	Fox-1_C		Calcitonin gene-related peptide regulator C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with Pfam:PF00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.	25.00	25.00	35.30	30.60	22.20	16.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.47	0.72	-3.58	6	257	2009-09-17 12:11:22	2009-09-17 13:11:22	3	4	42	0	88	228	0	87.20	67	26.35	CHANGED	sVPuFPYPs...sss...suuAaRGutL.RGRuRsV....YsshRAAsP...PsulPuYsGVV.YQDGFYGA-.lYGGY.AAYRaAQPAo........AssAAYSDuYGRVY.sA.DPY	............................................................h.lPGFPYPs...Ass.......sAAAaRGAHL.RGRGRs.V....YsshRAA.P...PssIPAYsGVV.YQDG.FYGA-...lY....GGY...A........AYRYAQPss.............AsAAA......YS...........D.uYGRVY..sA.DPY................	0	4	11	37
+12249	PF12415	rpo132		Poxvirus DNA dependent RNA polymerase	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF04566, Pfam:PF00562, Pfam:PF04567, Pfam:PF04560, Pfam:PF04565. This family is the second largest subunit of the poxvirus DNA dependent RNA polymerase. It has structural similarity to the second-largest RNA polymerase subunits of eubacteria, archaebacteria, and eukaryotes.	25.00	25.00	26.40	40.80	19.80	17.10	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.71	0.72	-7.02	0.72	-5.00	13	82	2009-09-17 12:12:17	2009-09-17 13:12:17	3	5	49	0	0	76	0	32.80	64	2.89	CHANGED	-FI+psLoYDMPsEllYLVNulIESTKpllss.p	.EFIRRSLSYDMPPEVVYLVNAIIDSAKRlsES.I..	0	0	0	0
+12250	PF12416	DUF3668		Cep120 protein	Gavin OL, Bateman A	lg7	Bateman A	Family	This family includes the Cep120 protein which is associated with centriole structure and function [3].	21.80	21.80	22.20	22.40	20.90	19.40	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.11	0.70	-5.24	16	109	2009-09-17 12:13:09	2009-09-17 13:13:09	3	8	80	0	73	121	0	295.20	39	33.78	CHANGED	hlVlsIlEG+sFspc.......+pplllpAphs........ucsLpTD...............Plspt-sstFsocLsWE........hD+psl+..........+h+sp+sPlKLpCaAsc.tsst+EsIGYllLslRus....ptsp.p....ps+WapLLus...capphKPEl.hlhlslEscsh.t.ts.p..h........psppsPsppu.....ss.h..s.tplhshhhs-pGhhQlGsssh.ssDhallslpltpsppLspL.hs.s..l.t+..t.sshhhhYslLGNDVTsc.pFpp.hsssa.hpcs..lRl+SSlpsL+hahspp.stL.Iplpp....t.......ppulusoplshssLlstssh.th.....sp+hsshpGsFshp..stscs...............ss-.htPplslsloLchc	.............................................................hlVlpllE..G+pFspp.......cp.lllpApFsGEpLtTD.....PlpHs-pPpFsTELAWElD++sL+ppRhQRTPIKL......pCFAlc.....sho.st+EslGYllLDLRss....pps..p....ts+WapLLus...+.......Ys+aKsEl..lulslEs-sp....ssc.th................KuptsPPcpu...ps.s.....tlsspsl..hshLtp-tGaaQIGP..s-h..ssD.FlhSloluaAp.pLcpL.lsss....Lstc....spFaFhYs..LLGN.-VTs-.sFpsLhs....P......sFpsERsS.lRlRSSlcsL+hYLshp.stLpIaLCs....G...........spu.LGssclsLssLLtpssh.ph.......sp+sssh-GuFhlpsss+scp...............sh-..htPplslolsLph.p.....................................	0	29	34	53
+12251	PF12417	DUF3669		Zinc finger protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 64 and 80 amino acids in length.	21.60	21.60	22.30	21.90	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.22	0.72	-4.25	23	311	2009-09-17 12:13:48	2009-09-17 13:13:48	3	38	80	0	172	301	0	75.70	43	14.96	CHANGED	hWhlDFstsps......hphs.css.ltp......hlsAahcNDsaaPRPt.......t..stpLWssFcppYl.suptlhpshhh...hcs	.....................h-hshhsshss.h.slE+K.h-up.us+............LlsLEGRTGssEKKLA................-CEKTusEhuNplEuKWsVLGTLLQEYGLLQRRLEN..............	0	16	39	68
+12252	PF12418	AcylCoA_DH_N		Acyl-CoA dehydrogenase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF02770, Pfam:PF00441, Pfam:PF02771. This family is one of the enzymes involved in AcylCoA interaction in beta-oxidation.	21.20	21.20	21.20	21.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.23	0.72	-4.26	232	1684	2009-09-17 12:14:12	2009-09-17 13:14:12	3	9	805	0	589	1505	340	32.30	33	5.44	CHANGED	ssYpuslRDhpFlLpElhshcthh..shssas-hs	........pYpAPlRDhpFlLpElLshcthh..shstas-hs.................	0	150	332	482
+12253	PF12419	DUF3670		SNF2 Helicase protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00271, Pfam:PF00176. Most of the proteins in this family are annotated as SNF2 helicases but there is little accompanying literature to confirm this.	27.60	27.60	28.10	31.00	26.50	25.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.51	0.71	-4.74	105	583	2009-09-17 12:16:04	2009-09-17 13:16:04	3	5	516	0	181	587	58	139.80	27	14.45	CHANGED	L.psstPpshp..Lssp-shpFLppsu.tLpsuGlsVlLPsthpt.t...tp+lplclps............................sss.sst......uhlulcsLlsFcWclulGs....psLoppEhppLsppppsLVcl+GpWVplDspclppstchhpp.ttpt.........loht-sLchshs	.............................shp..Lssp-shpFLspsuspLpsuGlsVlLPshWppht...ts+hplclps..........................................ttsss.ssp........uhhGhss..LlsFcWclulGs.............tsLocpEhpcLs...c....pppsLlcl+GpWltlDsptlccspchhpc.ttp.t..........lsht-hLphth.t..................	0	61	131	163
+12254	PF12420	DUF3671		Protein of unknown function 	Gavin O	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 96 and 116 amino acids in length.	22.10	22.10	22.30	23.40	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.60	0.72	-4.05	42	76	2009-09-17 12:17:00	2009-09-17 13:17:00	3	2	4	0	39	97	1	108.20	37	46.74	CHANGED	KKcGL..................c+LDsYCEKKlFsplcplpclscshshcKKpaKphlhKKYG...hhlll.sLhs.llGlIlslLht.ht.th......................................h..hphhFhhlhsslhlLhllYlhhKllKY-	................KKcGLcKLDCYCE+KIFsslD+lcKhtcstNhDKKsaKpl.llKKYG...htlIhssLhs.LlGlIlsILsh.tpsth.......t...........................h.thlsslshsFah.assIhlLsllYIhhKllKY-........................................	0	0	0	34
+12255	PF12421	DUF3672		Fibronectin type III protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is typically between 126 and 146 amino acids in length. The family is found in association with Pfam:PF09327, Pfam:PF00041. There are two completely conserved G residues that may be functionally important. Many of the proteins in this family are annotated as fibronectin type III however there is little accompanying literature to confirm this.	23.60	23.60	23.90	23.70	22.80	23.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.65	0.71	-4.02	25	1261	2009-09-17 12:19:22	2009-09-17 13:19:22	3	19	403	0	22	1470	7	135.60	56	15.88	CHANGED	lspsGphphpNuslpG..............slsAsSGshsssshspssphtGslpAppIc.G.....Dll+..........hh.tt.................h.hpsh..ss.sasRplhl..........................ttt.p.....hhh.pshshtlppstthlhstssssh....hssh.......hshPs.sp	..............LTPDG+LTAKNADISG..............sVNANSGTLN.....NVT.....INENCplhGKLSANQIE.G.....DlVKTVuKuF...........ss........................pasSGTlTVpl.DDQ....sFDRQIlIP....................ustapstpppppps..shYSoC+L.VpKNGsEIaspsshDsp...hlaSuV.......IDMPAG.............................................................................................................................................................................................................................................	0	3	5	12
+12256	PF12422	Condensin2nSMC		Condensin II non structural maintenance of chromosomes subunit	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.	21.70	21.70	22.50	21.80	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.94	0.71	-4.47	26	201	2009-09-17 12:21:28	2009-09-17 13:21:28	3	7	99	0	119	184	1	148.20	29	21.30	CHANGED	Llpshhssthlps.-Gp+hluhlhs.hpt.hhcchtshl+spl...phs+uhlptau-lhapuWKpu...............ptshppplEpshlpshhpsulcs.....ts.hhusphRphLpsFtpp+.hpttV-phL..hclhcPlLaRuLpssNspV...RtNuhtlhhp.hFPlpss	......................hLtsFhssshlts.p..u.phlShLhs.hphshh+thpshlcs.l...tths+slhphhu.-lhacuWppu................tphhpplcpspIQDhh.tulcL...............cp..sas+sRcsLthFhppK..h..tlcchL...hcl.hcPlLa+uLpssNupV...Rssuthlhlc.AFPlcs....................	0	35	52	84
+12257	PF12423	KIF1B		Kinesin protein 1B	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00225, Pfam:PF00498. KIF1B is an anterograde motor for transport of mitochondria in axons of neuronal cells.	22.20	22.20	22.20	22.40	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.43	0.72	-3.93	42	516	2009-09-17 12:24:20	2009-09-17 13:24:20	3	40	167	0	305	465	1	46.90	37	3.03	CHANGED	hpNRlhtMR.-hYpph........................................hptt............pp...........h.ptpDPFa-s..-paslIGs	..........................LcpRL..MR.-hY.pch......................t............................pps.sst......................cp............hhptuDPFY-p..c.apLlGs...........	0	90	120	213
+12258	PF12424	ATP_Ca_trans_C		Plasma membrane calcium transporter ATPase C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00689, Pfam:PF00122, Pfam:PF00702, Pfam:PF00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.	22.90	22.90	23.70	23.10	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.28	0.72	-3.61	19	534	2009-09-17 12:25:56	2009-09-17 13:25:56	3	22	95	2	238	453	0	56.10	47	6.66	CHANGED	GQILWhRGLsRlQTQIRVV+AF+SsL..tcshcpspSpsu.l+shhs.sph..slpcphpp.shlsppc	................GQILWhRGLNRIQT.QI....+VVpAF+Suh....h.p.....u..l..c+..pS.hsS....lHshhst.ph...h.t............s..................................................	0	32	49	134
+12259	PF12425	DUF3673		Protein of unknown function (DUF3673) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length.	22.30	22.30	23.20	23.60	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.47	0.72	-4.12	19	52	2009-09-17 12:28:21	2009-09-17 13:28:21	3	4	3	0	29	47	0	51.70	42	28.82	CHANGED	Rhssc-hhssspthshl-sc+t.h.......pc-suHApssssaspcchs.h....sspsph.+ts	......hhsscDhhToscchuYlEccKGYs.......E-EsuHAQsssVYANKKhl.Y.....usKsphs+..h.........	0	0	0	3
+12260	PF12426	DUF3674		RNA dependent RNA polymerase	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 40 amino acids in length. There is a conserved MFNLKF sequence motif. There are two completely conserved residues (E and P) that may be functionally important.	22.00	22.00	22.80	47.90	19.90	21.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.02	0.72	-4.55	8	125	2009-09-17 12:29:39	2009-09-17 13:29:39	3	2	47	0	0	100	0	40.30	63	3.25	CHANGED	LIKs-ERuALEAMFNLKFHlus.KspsYhIP-Y+slp.spP	..........LIKsDERuALEAMFNLKFHloGsKsRsFsIPsY+PQsLCpP.......	0	0	0	0
+12261	PF12427	DUF3665		Branched-chain amino acid aminotransferase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 23 and 35 amino acids in length. The family is found in association with Pfam:PF01063. There is a conserved TRT sequence motif.	25.00	25.00	43.40	42.30	23.80	20.50	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.30	0.72	-6.73	0.72	-4.51	3	14	2009-09-17 12:33:33	2009-09-17 13:33:33	3	1	12	0	3	14	0	26.30	72	7.06	CHANGED	M............L-YTVTRT-sPTSP-RLKEILA	..............L-aTVTRTENPTSP-RLKEILA.	0	1	2	3
+12262	PF12428	DUF3675		Protein of unknown function (DUF3675) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00097. There are two completely conserved residues (R and L) that may be functionally important.	21.10	21.10	21.10	21.10	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.46	0.71	-3.84	30	175	2009-09-18 09:02:28	2009-09-18 10:02:28	3	3	21	0	96	161	0	110.10	34	44.96	CHANGED	PGYTAPs.phsphscsslslp....usWp..ssth-.c-schlAhstuppphhpsth..s-hssssspuusaCRSlAllhMsLLLLRHsLslsh..sus-chuhsl.ho...LhhLRsAGILLPhYlhh+ulo	...............................PGYTAPP...hhp....schslslp............ssap....hsth-.c..cschlAhstuppphh.ps-a.s-hssssssuushCRSlAlI.......hMsLLLLRHslslsp...sss-c.shs...l..Fo...lhlLRsAGhLLPhYlhhhul.......................................	0	8	52	75
+12263	PF12429	DUF3676		Protein of unknown function (DUF3676) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 230 amino acids in length.	25.00	25.00	34.40	34.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.53	0.70	-4.75	27	92	2009-09-18 09:05:25	2009-09-18 10:05:25	3	8	2	0	40	93	0	193.10	63	27.25	CHANGED	TDsSVASES+SEESs.sSaEcLsEsDTDcQ.EEpsVcs.VPAAssSTVsAGSSVsEPAhAAESAtNS+sEDNAQLSEGcTuQQuT.sEspcSMQRDSDVQsQD.QSpELTEVsDVEtSSES.DsEpPEEEGcANDRSGGoTSsVuASLSM-TATusVsGEHQVQQSsELuAENcDVRSTGTGTTGAEpSLSLEAGDuNSERTMuSDSSLTPSKSDAEPTSAEsTDslSRTEG	..TcsSVASESpSEES..sSaEcLsEsDs-cQ.EEpsVcs.VPAAsSSTssuGSSVsEPAhAsESAtNSh.-DNAQhSpGETuQQsT.pEspcSMQRsS-VQsQD.QS...tc.TEhsDVEtSuES.Dpp.PEE-ttss-tSGtoTSsVuAS.sM-TsstsV.uEHQVQQSsEhusENsDVRSTGTGTTGAEpSLSLEAGDtNSERTMsSDSS.TPS+SDAEsTSAEsTDslShTEt..................	0	0	0	40
+12264	PF12430	ABA_GPCR		Abscisic acid G-protein coupled receptor 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 177 and 216 amino acids in length. This family is part of the abscisic acid (ABA) G-protein coupled receptor. ABA is a stress hormone in plants.	22.10	22.10	23.30	30.10	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.22	0.71	-5.17	44	301	2009-09-18 09:06:13	2009-09-18 10:06:13	3	10	234	0	216	311	1	172.90	36	36.74	CHANGED	p.ptthupThhG+hhphh.shhhulYCla+lhhshlphlhhh...............................ssssDslstslshhlp...........hhshpl...Dhp.hhspplShlLsGslhlsShpsllhohpp...hhphhsushs..ss.....................................hhsLlluplhGhYhlSolLLlRssLPt............ph.pshlsc............lLu............sslch.tFhcpWFDhlFllSulhohlhlhhtcphs	..............................t.thupThhG.+hhsh.h.GahFSlYClaKlhhshlsllhpp................................supsDPlopslplhlp....................ahs.hph.......Dlt.hhoppIShlLlGhlllsSlRulLhTlp+...hhhh.luushu..ss.....................................hllLlluplMG.hYFlSolLLlRhshP..........................-h.+shloc......................lLG..............plpa.sFac+WFDslFll.......Sulhollhlhltc+..s....................	0	82	125	181
+12265	PF12431	CitT		Transcriptional regulator 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00072.  There is a single completely conserved residue G that may be functionally important. CitT is a transcriptional regulator which allows transcription of the citM gene which codes for the secondary transporter in the Mg-citrate transport complex.	21.60	21.60	21.60	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.40	0.72	-3.80	48	854	2009-09-18 09:08:13	2009-09-18 10:08:13	3	6	644	0	81	293	7	29.40	49	13.06	CHANGED	lsQptVDphhptts....pspst..sp..LPKGIDpl	..AsQcplDcMFNshA......+s-sp...sc..LPpGIDt...	0	17	32	57
+12266	PF12432	DUF3677		Protein of unknown function (DUF3677) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length.	25.00	25.00	28.00	28.80	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.66	0.72	-3.54	19	104	2009-09-18 09:13:42	2009-09-18 10:13:42	3	3	83	0	79	115	0	81.20	45	4.34	CHANGED	l...L+hLstssGhtplRhhss.....p+lEhWlpNsKlp+.sp-L.LhhlhhNsss.......pstpDh-.slstLl+lth+sps...........lhshahtsl+cl	......lL+hLosoCGhtEVRhhul.....pRLEhWLpNPK..Ls..........R...sAQ-L.LhplChNCso.......+uscDh-.VlupLlKlRLKsKs..........LlNaahhCl+El.......................	0	29	37	60
+12267	PF12433	PV_NSP1		Parvovirus non-structural protein 1 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 109 and 668 amino acids in length. Parvoviral NSPs regulate host gene expression through histone acetylation.	25.00	25.00	67.70	67.00	22.30	19.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.73	0.72	-3.91	5	227	2009-09-18 09:15:31	2009-09-18 10:15:31	3	3	33	0	0	240	0	65.90	56	16.25	CHANGED	lLTYpHKQTKKDYsKsVHFGNMIAYYFLNKKKIsT-..+-cGYFLSoDSGahsNFLKppER+lVSKLYTDEpKPETVETTVT	.hpYhHKQTKpDYsK.VphtshlhhYhhNKcKIsc-..p.cGYahuusuGhh.................................	0	0	0	0
+12268	PF12434	Malate_DH		Malate dehydrogenase enzyme 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00390, Pfam:PF03949, Pfam:PF01515. There is a conserved AAL sequence motif.  There is a single completely conserved residue R that may be functionally important. Malate dehydrogenase is one of the enzymes involved in the citric acid cycle in mitochondria. It converts malate to oxaloacetate using NAD as a cofactor.	21.50	21.50	21.50	21.50	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.85	0.72	-7.06	0.72	-4.24	5	120	2009-09-18 09:25:20	2009-09-18 10:25:20	3	5	117	\N	46	104	24	22.60	67	2.97	CHANGED	s......osSc-DLK...-QQRAALRKAALEYHEFP	.............ss.................t+tpLRcAAL-YHEFP	0	3	20	33
+12269	PF12435	DUF3678		Protein of unknown function (DUF3678) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length.	20.40	20.40	22.10	21.80	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.70	0.72	-4.39	16	44	2009-09-18 09:28:31	2009-09-18 10:28:31	3	4	4	0	30	39	0	35.00	34	14.18	CHANGED	hhso-lhlpusus..........soSSushsHpppc+hFlchsol	.....hho-lhltAsus..........sooSsshhHpppc+hFlcasoh.	0	0	0	5
+12270	PF12436	USP7_ICP0_bdg	USP7;	ICP0-binding domain of Ubiquitin-specific protease 7	Gavin OL, Coggill P	lg7	Prosite	Family	This domain is one of two C-terminal domains on the much longer ubiquitin-specific proteases. This particular one is found to interact with the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110.	27.00	27.00	27.40	27.50	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.54	0.70	-5.14	52	419	2009-09-18 09:30:54	2009-09-18 10:30:54	3	25	258	2	276	415	4	231.30	28	22.05	CHANGED	phRhWhhsp.RpN..........+ThRP.......sp.l..p-.shTlpp..ltsp.ss.pt.th+lalElh.......................tt.....ss.pspp..slLlFlKhaDsppppLphlG+lalptspKls-..llPhlpchhua....sssTplpLaEEIK......sMh-.l...........c.ctohpp.....uElpDGDIIsFQ+shs......................t.psphthssshpaa-aLhNRl.VpFtsh...tpPpc.s...........sFsLpLSc+hoYDplupcVup+Lsh.DPp+LRFsssts.h....stpP+...h+...s...hspoLp-l..L	...................................................RhW.h.p.RpN..........tThRP..........sh....t-....s....oh..tp........hhp.....p...tp....................hplalEh..................................................................t.t.h..ss.s..ppp.....slllFlKh...a..Ds.p....p...p...p.LphsG+lal.ptss+.lp-..lhshlpchhGa.......sss..spl.LYEEl+.............................shh-.l...........c.c.ohpp.................sEltDGDIIsFQ+ssst.........................................psps...phssstpaachLhpRh.........Vh.Fpsh.p.spc.s.........................................................tFsltLSpphsYp..p..lscpVup....pLs.........h..DP.....hl..phhthts........pttPt...h+.......p....tpl.ph............................................................................	0	88	151	228
+12271	PF12437	GSIII_N		Glutamine synthetase type III N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. The family is found in association with Pfam:PF00120. This family is the N terminal region of glutamine synthetase type III which is one of the enzymes responsible for generation of glutamine through conversion glutamate to glutamine by the incorporation of ammonia (NH3).	25.00	25.00	31.10	30.80	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.83	0.71	-4.85	106	750	2009-09-18 09:35:47	2009-09-18 10:35:47	3	3	601	6	222	705	101	162.80	58	23.02	CHANGED	ppls-hFGppVFscpsM+cpLPKssY+pLpcoIcpGptL.DhplA-sVAsAMK-WAl-+GATHYT.HWFQPL....T..GhTAEKHDoFls.sss-.G....p.slhcFSGKpLlpGEPDASSFPsGGLRuTFEARGYTAWDsTSPAFIhcp...s...sLCIPTsFsSYoGEALDpKTPLLRS	...........p.hs-hFGppVFscpsMccpLPKplYKplpcsI-pG.ptL.DhplADsVAsuMK-WAlE+GATHYT.HWFQPL........T.GhTAEKHDuFls.sssc.G.......p.sltcFSGKpLlpGEPDASSFPsGGlRuTFEARGYTAWDsTSPAFlh-........sTLCIPTsFhSYTGEALDpKTPLLRS...............	0	108	185	212
+12272	PF12438	DUF3679		Protein of unknown function (DUF3679) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length.	20.90	20.90	21.30	23.10	19.80	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.61	0.72	-4.61	14	131	2009-09-18 09:40:58	2009-09-18 10:40:58	3	1	130	0	16	88	0	51.90	54	47.82	CHANGED	+sllhshlhhhGVLhGMQpANcGhppMKGYcDsohpsshplscscssphEAulLGp	...hh.hhlhhhMVlAGVuLANHGLKSMKGYpQhSYEQIAHMTGTcupssEoEILGp.......................	2	2	8	10
+12273	PF12439	GDE_N		Glycogen debranching enzyme N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is typically between 218 and 229 amino acids in length. The family is found in association with Pfam:PF06202. Glycogen debranching enzyme catalyses the debranching of amylopectin in glycogen. This is done by transferring three glucose subunits of glycogen from one parallel chain to another. This has the effect of enabling the glucose residues to become more accessible for glycolysis.	21.30	21.30	31.50	23.50	19.50	15.40	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.36	0.70	-5.11	94	351	2009-09-18 09:42:53	2009-09-18 10:42:53	3	6	336	0	118	343	25	219.70	31	32.83	CHANGED	+EWLlTNGlGGYAuuT.lsGs.TRpYHGLLlAulps..PhsR.hlllocL-Eplth.ssp...........pasLuspca..........sss.htspGap.aLppF.ph-.shPhWpaph....sssh.lcKclhM.pu..............................................................pNsshlpY..p......hhpu..sp......shpLplcPhlshRsaHshspss..h.........................thphpht.h.tp..s.............lplpshs..........thssltlh..hs.t.....u..ph.httss............WahshpYshEpc.RGhssp-DhasPGhhphsLps...Gpslhl.s	............+EaLhTNthGuYusuT.lsssNTR+YHGLLlsslss..sss.R.alLLSp.L-Eslh..pGt...........................pasLuhp.....+a..........tss.hpPpGa+..alpcF..ph-..tlPshhYcl.....usll.lcKclhh.pt..............................................................pNpl.hlc.Y.p.........lhsu......ps............sspLcl+PhlsaRsh+tho+ps.th...........................shph..s..ps..G..............lphshhs..........shspLhhp.....hsp.......s..ph..hptss...........WYpshpYstEp-.RGhshpEDLasPGhFchslpt.G-slhh.s................	0	48	89	109
+12274	PF12440	MAGE_N		Melanoma associated antigen family N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with Pfam:PF01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognised by cytotoxic T lymphocytes (CTLs).	21.90	21.90	22.00	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.18	0.72	-3.70	33	530	2009-09-18 09:45:57	2009-09-18 10:45:57	3	8	23	0	267	572	0	89.70	29	28.27	CHANGED	+uQKSptpstEcchQAptEspsL.ssQsssu-cp..tusuSs.sh..ss.ppssu.uGssssPQ.usQtAsossoshsu.s.........stspSsEuups.ptEE.ssuso	...............................tQ+SphpthEcp.hpup.....sEsp.......uL..suQs...sssccp..........pssS....S.......u...s...s.......hht..ss.......ppss..A.uss.ss.....PQ.u.PQtuss.ssoshss..s....................shs.pS.sEuupu..QpEc.ssss................................	0	24	24	36
+12275	PF12441	DUF3680		Protein of unknown function (DUF3680) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is approximately 40 amino acids in length.	27.70	27.70	28.20	28.90	26.70	27.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.80	0.72	-4.11	33	91	2009-09-18 09:47:12	2009-09-18 10:47:12	3	2	76	0	37	92	16	40.70	32	46.20	CHANGED	hp.KplP.cFco-tEtcpFW-pHDso-YhD......phpplpFs.h+.	..........ctlP.phco-pEtccFW-o..pDhT-Yhs.......phpslph............	0	7	24	32
+12276	PF12442	DUF3681		Protein of unknown function (DUF3681) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 212 amino acids in length. There is a single completely conserved residue G that may be functionally important.	24.30	24.30	24.50	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.59	0.72	-3.85	22	90	2009-09-18 09:49:35	2009-09-18 10:49:35	3	6	6	0	54	67	0	96.20	30	49.03	CHANGED	uspsh.ph.hALhshGlsTsusAhhshh.........hpsP..sGhhs.t.....hhYhlh...LsushlsGlstshsuhWVu.ssstt.....RRusG..+pllhsulsPLlh.s..........sh........uuhs.......l	..................s...s..th.tALhshGlsssuhAhslAh.......apsP..uGhht.h....hh...hYals...LsushlsGluplssu.h.WVu...sssts...........R+usG..+pllasulsPLlh.s.hulss...l...............................	0	0	10	27
+12277	PF12443	AKNA		AT-hook-containing transcription factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.	26.20	26.20	26.60	32.90	25.80	26.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-4.02	4	80	2009-09-18 09:52:05	2009-09-18 10:52:05	3	1	26	0	32	83	0	103.60	40	11.37	CHANGED	QpQIps..pl+ssptsLpu.E..puCpc.pPssQhssSpuoshhFphhpchct.h.+Ltpph-pLKs+lcphp+chc.susspLQDpp.shppL..psspLstP.Gss	................................ppQlph..pl+htpthLpt.E..puhpc.psspQhssSpuoshhFp.hpchct.h.+Ltpph-pLKs+lpphppc.c.sussph.....Dpp..sL.pLp.p.phL.ts.ht.s..................................	0	3	3	5
+12278	PF12444	Sox_N		Sox developmental protein N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 69 and 88 amino acids in length. The family is found in association with Pfam:PF00505. There are two conserved sequence motifs: YDW and PVR. This family contains Sox8, Sox9 and Sox10 proteins which have structural similarity. Sox proteins are involved in developmental processes.	22.30	22.30	22.80	24.80	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.27	0.72	-2.87	24	321	2009-09-18 09:55:34	2009-09-18 10:55:34	3	2	129	0	110	284	0	74.70	53	17.54	CHANGED	ssSPuhS--.sshSPs.s.usuGu....-o.......psst.tp........s.............................phcp-s-......D-+FPssIREAVSQVLcGYDWTLVPMPVRV	..........................................s..SPshS--.....pshSPs.s..Susuu........Do.................psststp..t......t.ts.............................chcp-s-.......--KFPlCIR-AVSQVLKGYDWTLVPMPVRV.....	0	14	22	59
+12279	PF12445	FliC		Flagellin protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 125 and 147 amino acids in length. The family is found in association with Pfam:PF00669, Pfam:PF00700. There are two completely conserved G residues that may be functionally important. This family is the flagellin motor protein which confers motility to bacterial cells.	21.90	21.90	21.90	22.50	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.99	0.71	-4.02	27	245	2009-09-18 09:56:18	2009-09-18 10:56:18	3	4	177	0	2	121	0	140.00	37	25.15	CHANGED	shpssuss......sussuoIThss....Gsohshsuu.........sss.......hsstssolSA-shtusspssu....aTs...ssus...tsassu..sssVshsu....................sssYscsDG.pLTTsss..s..sYahpsD.GsVTs....................ssGpslYhsADGclTT-Aso	......hh..tsuusuucsuolThs........GTpaohusus.........s..s............ssshsAoVSt-slhutsKusu.....sh.....ssuo.....hTa.ssGh.otslshsust..................sssYlDscG.slTsssshss..sY.lpcD.GoVTsst.................ssusGssVYVsusGKlTT-sTS...	0	0	1	1
+12280	PF12446	DUF3682		Protein of unknown function (DUF3682)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 125 and 136 amino acids in length.	25.00	25.00	97.10	97.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.07	0.71	-3.86	33	59	2009-09-18 10:02:37	2009-09-18 11:02:37	3	1	2	0	1	59	0	133.60	61	40.95	CHANGED	usGG..pGoG.GsuSuuuu.......ss...Puusssusussss..sAsuVDSSAGSSsGpAGSSGoNsSNTTGDSsTGDQos.AAAAApsSSPPEGPAGTTSGTGHTRQEEE......EEE-pEKQQQSDEsQVQ.QHQQHEHPAEsGE..ESA	................................................................................sspusGGsuuGuus.............sus..suusssus..u.sssss.......sAssVDoSAGSSsGpAGSSGoNsSNTTGDS.....sTGDQTs.AAAAApsSSPPEGPAGTTSGTGHTRQEEE......EEEEpEKQQQSDEsQVQ.QHQQHEHPAEsGEESA....	0	0	0	1
+12281	PF12447	DUF3683		Protein of unknown function (DUF3683)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF02754, Pfam:PF01565, Pfam:PF02913.	21.40	21.40	59.10	57.90	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.46	0.71	-4.26	42	271	2009-09-21 10:06:30	2009-09-21 11:06:30	3	6	267	0	96	256	43	122.00	63	9.53	CHANGED	.ssRlREIPYNYTSFSDREIVlRLLGp-sWphLs-LRsERpTGRSARMLaEVLGDIWVVpRNPYLpDDLL-sscRRptLl-AhpHRLspIccRps.............ssp+VtpLlsuA+pAVptFppp	...s.sRlREIPYNYTSFSDREIVIRLLG--AWplLs-LRucR+TGRSARMLaEVLGDIWVVpRNPYLpDDLL-NPKRRthLlcALpHRLsEIcKRRs...................csppVphLlsAAccAVccFspp.......	0	19	55	79
+12282	PF12448	Milton		Kinesin associated protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 143 and 173 amino acids in length. The family is found in association with Pfam:PF04849. This family is a region of the protein milton. Milton recruits the heavy chain of kinesin to mitochondria to allow the motor movement function of kinesin.	22.30	22.30	27.40	23.70	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.31	0.71	-4.05	16	296	2009-09-21 10:09:17	2009-09-21 11:09:17	3	7	65	0	163	225	0	164.70	29	31.66	CHANGED	sssptpsSsssssts..su....u..........u........h.hs...u..hhLpp+slSsts..sspS......st.tp.s...............................PuoPssp-LptAL+pLo.......h.......pRcNaLup+.hhshppEtphpthupt..tst.........P.....s-SlhSsss.....sth..............tphhLP-KLQ.IVKPhEuS	.....................................................................................................................p..........s...s..GSspo.Ss..o...............................hossc..S....ohphos..u...shlLpp+s..hSstlh.psts........tst.pp.us..............................P.uTPssschpsALppLo..........h.......tp-NaLu.p.....+..hhp...pEh+hpphs..................P......o-S..hh.Slus.................................t+hhLP-KLQ.IlKPhEu...............	0	13	27	87
+12283	PF12449	DUF3684		Protein of unknown function (DUF3684) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.	19.50	19.50	32.70	23.20	18.50	17.90	hmmbuild  -o /dev/null HMM SEED	1093	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.96	0.70	-13.85	0.70	-6.98	22	109	2009-09-21 10:18:36	2009-09-21 11:18:36	3	7	94	0	90	113	0	917.70	39	61.55	CHANGED	LTFVu.LcsIElalDDasll+LpKKsuPshslsIP+clcT+TspGLM+lpslpppssQlDAshMphV..thpssust.h..tt.c..sss.......uoL+SFFS+housussp...cstpsppss..pttsptD...........ltphspuolFL+IsTAsIpsslupuhusELERATKKPPPKpoplAlLTsuYsph.AStts.................tspss..IFuulLPo+..uG..RlFIGFPTpQTTGlsuHlSAPSlIPTVERESIDLNsRalupWNhEhLRsAGllCRlAapsEMuslpscl..t.....t..ttuthccpcltsllscAlHshppFsF+-STPSotlGphIE-uFWoCs+sss.IElLSTpGVlsScpVRhsscsLS.FhcuIPVlPc-hhssApcFlp+Lp-hGLls-lTlsDIhpELcupsLspsQlh-FLpWl.......uccusuupl-.sshppLLssAVAs.ps.s.us.ss+llsLusIssalNPp+I.....Ps-LPlPPsllPapaoKsLspppLpul.GWpELpllsWLpaLlp...susscs.....-pDlTpSssFuspVLsVLSKpW-s.LusuoKpsVlshLpspTlIPTKhGM++PsEsYFsoV+LFDDLPlV.....pGlsulKEKhLsALGVRKTV-LslIF-RLLtssststt......ptcWSHVDLI+YLuSVcsDIPspDlcRL+pTslCsAE........ssppsptpRYKlS-LaEPc-uLRsLtLPllcW...PGcapssSsEu+FLhtLGL+saPss.-llclhu...tusDhpL+sKAhsYalspat.NsYusach..utsshsFLPl.p.....spp...pLusPppCFTscsAulhGFslLRp-L+s..HAsKhGVppHPshspClshLlppPPpocp-A+tlFpYlAuRlu-lsssc..lc+lupAtIVPV.pcphs.........pptpsh..phl......sPppCYL....Gcup-YpcIFDFVDFGtcANhFLhusGuKcEPTptElAphLl+EPARl.uthQSs-................+YLpLLRslA-shshL++c..+pLhpcM+pusFLLuS+-lspptpptst................pps-----psl+EWsLspApDhVlVDDhpSapLF+-plLu...APQEEhL.EsFYhsLGu.sLSuLVcEchchGs..hssDQc.AtcLcKlIhERo+LFLH	.....................................................LTFVu.LppIEhalDsapllpLpKKsuPshplslP..+slpo+Tt..pGlM+ltslpppssQlDAshMpsl.....tWps.sss..tt..ttt..s.t...................soL+o.FFS+housusts.................psts.p.t.t..p.t.tc-...............lhthpsuolFL+lsoAplpsplspuautELERATKKPPPKpTplulLTsS.....asph.uStss....................tpstclFuullPs+....uG..RlFIGFPTtQTTGhshHlSA.SlIPTVEREuIDLNsRalppWNhEhLRsuGIlsRlAassEMuslpsch..t.........t.tttst...hptctltthhscAlHhhppFsFpcSTPoutVuphlE-uFWsC.pp.ss.l-lhSopGll.sppVRlss...c-lo............FhcsIPVlPcphhsss..Flp+Lh-hGLlp-lTlsDlhpELcs+sLsppQhhpFlpWh.........sppuhssplc.sshppLLpsA.......V......As..........pp......................s....ss.....sspl...lsLuslpsalssp+I.....PsclPlPssslPhth..o+slsttpLpul...GW.p.tLplssWlpaLlp....sstsps.....-pslTpospFuhpVLsllSKpW-s.ls.ss.+psl....hshL.pshsslPTKhG........M++PsEuaFsoV+L..F-DLPsl.........puhpslKEKFLsALGVRKTV-LphIFpRLls...t..t...........ptcWSH..h-LI+YLsSVpsDIPspDhp+L+pothCsAE......................t......tstpsptphY+ss-LaEPp-slRsLt.L.PllpW...Pupaps.sS.Eu+FLh..LGL+paPss.pllphh........supc.....tL+spAhsYalspah.s.....tYssaph..ut.shshLPl.p.........sp.....t....tLssPppCFTs.tAslhGFtlL+p-Lps....HAsKFGVtpcPshttClshLl....tpP...............PpspppAthlFtYhusRlu-ls.sp..ht+ltpu.IlPl.ppt.s................ts.h...thl......sPppCYl.......GpuppYtsI..FDFV.DFGtpANhFLhtCGuKpEPTp.ElAthhsp-PsRl.shhpos-................+YLpLLRslA-shshl+..+s+tLhpcM+pusaLLus+-lssttpt...................tts.----tsl+papLspApchlllDDh.oapLF+-plls...APpE-hL.EshYhtLGu.tLSslVpEchph.Gs..hstcpp.AhpLp+hlhERo+LFLH..........	0	34	55	75
+12284	PF12450	vWF_A		von Willebrand factor 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00092. There are two conserved sequence motifs: STF and DVD.  There are two completely conserved residues (E and N) that may be functionally important. In hemostasis, platelet adhesion to the damaged vessel wall is mediated by several proteins, including von Willebrand factor. In solution vWF becomes immobilized via its A3 domain on the fibrillar collagen of the vessel wall and acts as an intermediary between collagen and the platelet receptor glycoprotein Ibalpha (GPIbalpha), which is the only platelet receptor that does not require prior activation for bond formation.	25.00	25.00	42.90	41.80	20.80	17.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.15	0.72	-4.29	102	412	2009-09-21 10:23:44	2009-09-21 11:23:44	3	14	391	0	114	363	52	102.50	46	17.29	CHANGED	ssshss.....spEpatphppNshhssuppPlSTFSlDVDTASYuslRRhLspG.pLP...PssAVRlEEhlNYFsYcY.stPs.........s.s.pPFulssEhussPW.NspppLl+	.................sstt.....s.sspcYpphs-Nsl+psup..sPLSTFSlDVDTuSYuNlRRaLN.p.G.pLP...PsDAVRlEEhlNYFsYDa.shPs..........s..s.tPFulphElussPW.NppppLl+.........	0	48	76	95
+12285	PF12451	VPS11_C		Vacuolar protein sorting protein 11 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. Vps 11 is one of the evolutionarily conserved class C vacuolar protein sorting genes (c-vps: vps11, vps16, vps18, and vps33), whose products physically associate to form the c-vps protein complex required for vesicle docking and fusion.	21.70	21.70	21.70	22.30	21.20	20.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.37	0.72	-4.10	39	245	2009-09-21 10:32:19	2009-09-21 11:32:19	3	9	213	0	176	248	0	49.00	36	5.09	CHANGED	ssc.pslcsl+csQpc.......stcpa-lFpptL...cpopDpFpllo-ahGRGlhpp	..........scscplhshh+sQcp.......st-pHDhFpppL...cpSpDpFullA-aFGRGVhs.......	0	48	91	145
+12286	PF12452	DUF3685		Protein of unknown function (DUF3685) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important.	25.00	25.00	47.00	27.40	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-10.89	0.71	-5.14	37	133	2009-09-21 10:33:30	2009-09-21 11:33:30	3	3	97	0	60	145	115	156.80	29	37.26	CHANGED	l.hsclPhs.pLhshLlhppsLhlDsthhssssscAhtphEhLLpNhlIplANslhp.lLNphuchppl.....+phlappphlSoR-lERhRNpLsWphRhppahpcPpsIaESpapLahlsspuIpph.lasPRppELppLsulthhVTLlLEhRDAlAPplcullthlGpslValLTpVlGRuIGLlGRGIlQGlG	........................................................................thllpshllphAshlht.hlp.hu...pl.....pp.hhp.ph....lSoRplp+hRNplshp.hhpphhppshtlaEsphpLhhlptt.t..Isph.l..sRppELppLphhph.lolhLEhpDshsP.lpshlphlGshhsahLspllGRulGLlh+GIhQuhG..........................	0	10	38	52
+12287	PF12453	PTP_N		Protein tyrosine phosphatase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00041. There is a single completely conserved residue L that may be functionally important. This family consists of various protein tyrosine phosphatase haematopoietic receptors, e.g. CD45, which dephosphorylate growth stimulating proteins. This limits growth signalling in haematopoietic cells.	21.90	21.90	21.90	22.50	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.56	0.72	-6.82	0.72	-4.23	7	91	2009-09-21 10:35:08	2009-09-21 11:35:08	3	16	27	0	5	93	0	27.30	48	5.26	CHANGED	LKLLAFGF.AFLDstsaVsGpussssssG	..LKLLAFGF.AhLDo-sFVTGpospsssos...	0	2	2	2
+12288	PF12454	Ecm33		GPI-anchored cell wall organization protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. Ecm33 is an essential cell wall component and is important for cell wall integrity.	23.20	23.20	23.40	23.40	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.88	0.72	-4.08	18	53	2009-09-21 10:36:24	2009-09-21 11:36:24	3	3	53	0	38	48	0	40.10	45	10.10	CHANGED	MthlKYhLPA.LAAusushAs....sCu..tsTtTIpsQuDAsuLu	.........M.hhKYlLPA.LAsAGsAhAtt...sCs..tuohTIpsQuDAsuLu.	0	7	19	32
+12289	PF12455	Dynactin		Dynein associated protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with Pfam:PF01302. There is a single completely conserved residue E that may be functionally important. Dynactin has been associated with Dynein, a kinesin protein which is involved in organelle transport, mitotic spindle assembly and chromosome segregation. Dynactin anchors Dynein to specific subcellular structures.	25.00	25.00	25.40	27.20	21.30	24.70	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.61	0.70	-5.48	30	281	2009-09-21 10:37:31	2009-09-21 11:37:31	3	11	178	0	166	278	0	267.40	33	22.25	CHANGED	-L--hcsspp...pEs-ssphsspspshhslNhKLQsosuKApsKsIDlELp+hEuppuspHLpllphaLP-....ahc..u-+DulL.slLhhpRlutKusLlsstlpc+..........htpps.....hsupht-phh..hsscllppLshlsslsc+FhshlspCosEpFschsshh.EhpslE+tlDtaI-hLK+sclsEppssspLp+slshhscLtpsh.hs.....sph.shspphhtpsthhpstlDpsssshuhl+.shlpsthssssp............hhphhpslhspscusKhhspKlh...........Rpl	.....................................cLp-hppp.ps..ppptusch..ppp.s.tshshKlphutoKApsK.........sI-hELRphEstpAspHlslLpuF.hP-s...Fhc.........uGD+DslL.sLLLh.RlhtKAcLltppspE+.....................htcps......hpGsss.-phs......austllhpLshLpushc+atpulspCos-.hap+hushhsEhss..pERsLDhhI-LL++....DpLDEssss-.sLp+sItahpHLhpla.ls....pp.tsps..pltsphphhposLDshuspsupl+.shlQ.ss.....ppss-............................lhhhlcsL.spspsh+phspKlpRph............................................................	0	61	85	128
+12290	PF12456	hSac2		Inositol phosphatase 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.	21.80	21.80	22.10	22.50	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.30	0.71	-4.70	32	312	2009-09-21 10:38:54	2009-09-21 11:38:54	3	8	175	0	215	308	0	111.30	27	15.56	CHANGED	tst-....hphtphhppAl-ps.pphllsc.s....EchluuWhLh.....sscp.s.....s.p-plLLLTcpulalspaDats-+lspapRlsLsslppIphGhh.tsshp....sppcshshhlpaptss	..............h...c....hphtthhppslcsh.pp.hllss..s........-ph..hGuWhLh.....ps.ct.s..........s-p-plLLLTc..pulhlscYDhphc..Kl..spapRlsLpslppIphGt..a.hssht..........sc.pt.shplpap...s........................................	1	67	94	152
+12291	PF12457	TIP_N		Tuftelin interacting protein N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with Pfam:PF08697, Pfam:PF01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralisation of enamel - tuftelin.	22.20	22.20	23.60	23.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.66	0.72	-3.98	32	238	2009-09-21 10:39:50	2009-09-21 11:39:50	3	7	182	0	141	228	0	99.20	30	12.68	CHANGED	s-s-...-hE...cFEloDhDlcsE...........aNssRpRp..+poKcptlYGIaAppc-s-ppp.ttt.t...........ts++tpDYot.......PlsFVuGGlppsupc....cccpptppsp.....cpsccpst....ss	.....................p...-t...-h-pa-h.s-hDhpsE.............aNPpRpR+.....hpoK-pAhYG.laA-cssD-ptst.h...............ss++s+DYot.......PV...sFlSuGlppuupcctpppcppp...pppt.......................ttt....................................................	0	51	73	110
+12292	PF12458	DUF3686		ATPase involved in DNA repair 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 450 amino acids in length. There are two conserved sequence motifs: DVF and SPNGED.	25.00	25.00	118.90	39.80	18.10	17.70	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.31	0.70	-6.22	31	104	2009-09-21 10:40:47	2009-09-21 11:40:47	3	5	101	0	36	112	9	438.60	47	26.48	CHANGED	cLpp+sppLNppRh-hFGus-hcLlGstRlRTENNClsRDIVpVG.................shlLFGYNVahGL+p-s.plsDVFSlach...........tpss.......sFcht.hshst....hLsDspFhpDFp-LY+YY+ss+LhpLthh.cs+LLAlFQlG-phpDlRVFRWplsscGt..pYlDsRGERDhshPspHDF-WpcsoR-s+VtG+HPHlSI..hDcVFVETlGGDLTIKlENNT-oGcGIYuEPV--.sQSLDDAclcYAclGsLILL+lhPYpEppaRYlVFNs+pppVhRlDuIGpAClpLP-DpGIIFPGGYYL.poG-hKsF-pshs..s....hcFcRslRSPNGEDVLYVFaptppGphlLhsYNlIc+plpsPlhCHGaulh-DGchllF+.up.-EPTRlHPhQlWQTPahS-pa.Aust..ssssuhLt+IGNs-LVRGlS-shulsphlpcp..ssosthYpsLhpsspclhDsYa	............LpppsppLNtpRh-.FGusphcllGp.RlRTENNClsRDIVpVG.................chLLFGYN.V...alG.L+.pEs.plsDVFoLY+h.....................t..spta-ht.hshsss...h.LsDssFlpDFs-LYpYY+ss+LlpLthp.-u+..LLAsFQlG-chsDlRVFRWplss.....DGp..pYlDsRGERDhshPst..aDF-WpcsTR-.pV.GRHPHlsI..h.DpVFVETlGGDLTIKlENNT-sGpGIYpEPVp-.sQSLDDAplcaAclGsLlLL+lhPY+EcpaRYLVFNohTppV.RlDuIGtuClpLPEDpGIIFPGGYYL.QsG-hKsF-...pshp......s....hcFcRplRSPNGEDVLYlFap.ppGchlLhsYNlIc+plpsPlhsHGaulh-DGchllFc.u.-....s.cEPoRlHPhQlWQTPFso-ca...AApp......ss...tsuhLsRIGNA-LVRGlS-hhsls+hlppp..ssotthYptLspsspclhDsYa.............................	0	12	25	33
+12293	PF12459	DUF3687		D-Ala-teichoic acid biosynthesis protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (L and Y) that may be functionally important.	25.00	25.00	30.80	29.90	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-8.16	0.72	-4.72	33	811	2009-09-21 10:41:44	2009-09-21 11:41:44	3	2	808	0	47	183	0	43.50	43	89.74	CHANGED	h.....hhp+....ssspFlh+TlFYFhILlsLlYLYuYpGhspusFIYNE	................tpphhpFlh+TllYhhIhluLlalYua.pGpspusFIYNE....	0	8	19	30
+12294	PF12460	MMS19_C	MMS19_N;	RNAPII transcription regulator C-terminal	Gavin OL, Coggill P	lg7	Prosite	Domain	MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription [1]. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2]. This domain apparently shares homology with some HEAT repeat sequences.	27.00	27.00	27.00	27.20	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.33	0.70	-5.75	60	284	2012-10-11 20:01:02	2009-09-21 11:42:55	3	10	227	0	192	312	0	381.10	21	40.43	CHANGED	lsthl...stLscsssst.........................tphpphLcsLspluspppl.....hcslsh.pLls+lshhhp.......................ssphshslLpolhplhppptppp.....shshahpp.llshh.hphshsssspsps...........psLphluplhshllppLstpcppph.hp...plhshFh.........................h..ttt....tppphlhlhstlLuuLs+sssh......ptsp....LLpplhphshspss......thh+huhhchluhLlNK.hs...psp..........hpshLpphhpph........tt.tp.p.pslcllhWlsKALllRspstusphlsp..Lls......LLss.........pph...uptsAcuFplLls-...cslhst...............pptssl+lLaKQ+hFsplhPhl...hptacssss.................K.sY...LpALStlLp.slP..psllhscLspLLPLLLpoL........shsss...p...........lph..usLpTLtshlc-s..spllpc..alp..oLlspLLplu	.......................................................................................................................................h.phLphlstlshp.pl.....hp.h...hlhptl..h..........................................p.t.hhhhhtsl..hhpptt.t.........p.thhhpp.hh.hh.hthhhts...ttt.................................p.thLshhsplhshhsppls.phptp...hp..........ph.hslFh.....................................................h..t.t............t...ppphlhlhh.shl.suLs+ssphs........phtp.......................lhppllphs..hspss...............htphshhc......hhu.sLlNK.h.ssp..................thp.phlphhhpph..................................t.t..p.psh....pllhWlsKuLll....R.h..p..sh.ssplhsp..Lhp..............LLss.............................sph......u.tsAcuFslLhs-.....ss.lLsp...................................tstssl+lha+Q+hFsphhPhl.......lpthcssspt.......................................h+ssa...Lp.uLutlLp.plP....psl.lhs...clss.Ll...sL...LlpuL.........shsss.....s............................lph..usLpsLpsll.cs....sphhpt..alp....sLlsphLph......................................................	0	57	96	156
+12295	PF12461	DUF3688		Protein of unknown function (DUF3688) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is typically between 79 and 104 amino acids in length. There is a conserved YRW sequence motif. There is a single completely conserved residue Y that may be functionally important.	25.00	25.00	25.70	25.70	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.69	0.72	-3.60	38	86	2009-09-21 10:44:18	2009-09-21 11:44:18	3	2	6	0	0	86	0	91.90	31	26.06	CHANGED	DNKaYallh+spps.......ssWcIhK.FpNsppth........hh...tph............................................shhK.ulYRWsGssEP.phPs....ID.ssGpIpsW..........p	......................................................................................................................DNKaYhllh+ppps.......ssWpIhK.Fppsppt..h...........hh..t..t..h.......................................a...........shhKulYRWsGs.sEP...phPp.....ID.sTGpIpsW.....p.............	0	0	0	0
+12296	PF12462	Helicase_IV_N	Nucleolin_N;	DNA helicase IV / RNA helicase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 170 amino acids in length. This family is found in bacterial DNA helicase IV, at the N-terminus of Pfam:PF00580.	21.40	21.40	21.50	27.40	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.57	0.71	-4.60	36	672	2010-01-05 17:03:59	2009-09-21 11:51:44	3	8	665	0	62	352	3	164.40	57	24.00	CHANGED	McLpuoshuphlsQpsYpplcL.ssulploucp+phhIPFsplt.slps+RGllWGcLpFthss....ppslpl+GhpWp-sppFh............cplhpsappWspchschtsphLsphhppIpchpptspalscppltslhcplcpthpsLshslschtph.sspt...apphttWLpc	......MELKAToLGKRLA.QH.PYDRAhILNAGlKVSGDRHEYLIPFNQLL.AIHCKRGLVWGELEFVLP-....-KVVRLHGTEWuETQ+Fa.....................HaLDAHWpRWSsEMS-lAutVLppQlchIupRTGcN+WLTREpssGlpppIRQuhuALPLPV..sRLEEF-sCREh..WRKC.AWLpD..........................	0	4	19	40
+12297	PF12463	DUF3689		Protein of unknown function (DUF3689) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 399 and 797 amino acids in length.	21.70	21.70	33.90	33.40	18.70	21.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.78	0.70	-5.64	8	115	2009-09-21 10:58:33	2009-09-21 11:58:33	3	4	60	0	63	117	1	265.30	55	34.69	CHANGED	Vps.ltchtLl.sLsphF-pL.Whhptsp...hth.s.sssCosc.uLKIQFLRLlpsFsD+cpsp............tt.p..h.h..s.t..ss..s+shttcuppGLls+lLpshtp-st-ShaRFWlApuVEuFLRGssshtDQhalhpRGLlEHlLppIlcusscspcsLQhpFDLLGELhKFNpssFcRhsphlss-.KFph..FlctlsosLVDSNhFlRsVlLSL-pFcppts-hs..................tpshpcs+hlhhhp............spNph+hLpcLIshIplpslsQ-NlsCLNTuLlILhhAc+sGcL.hYLpuLRpt-hp	.......................................VH+MlAEF+LIPGLNNLFDKLIW...RKposS.s.hV.lH.uHNpNCDCSP-loLKIQFLRLLpSFSDHH-s+hlLhs........................................phsphSAlshc..sslPElcullNo......cRoLV..CDGK+GLLTRLLpVMK.+EPs-SSF....R..FWQARAVESFLRGsTSY..ADQhFLLKRGLL.......EHILaCIl....DScC.+.SRDVLQSYFDLLGELMKFN........lDAFKRFNKYlN.......T-.tKFQl...........FL.........pQINSSLVDSNMLVRClsLSLDRFEsQs.DhK......................................VscVL....SEC+LLuYhu.................ps.sphoFLFRLINIIpVQTLTQENVSCLNTSLVILMLARR+t+LPhYLphLpchEh.s...........................................	0	26	33	45
+12298	PF12464	Mac		Maltose acetyltransferase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00132. Mac uses acetyl-CoA as acetyl donor to acetylated cytoplasmic maltose.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.54	0.72	-3.95	351	3057	2009-09-21 11:01:47	2009-09-21 12:01:47	3	32	2089	58	602	2037	48	54.50	30	25.99	CHANGED	cEKMluGcl..........Yps.t..........Ds...E.LhptRtcu+clhtca.N.........ps...p...p............p.tp........cRpplL+cLhGpsGc	..................hEKMlAGch..........Yps.t..........Dt...p.LhpcRh+A+plhtcaN...............ps...t..sp................-.tp............cRppllccLhGpss................................	0	166	343	483
+12299	PF12465	Pr_beta_C		Proteasome beta subunits C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00227. There is a conserved GTT sequence motif. There is a single completely conserved residue Y that may be functionally important. This family includes the C terminal of the beta-type subunits of the proteasome, a multimeric complex that degrades proteins into peptides as part of the MHC class I-mediated Ag-presenting pathway.	20.30	20.30	21.40	21.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.70	0.72	-4.69	63	391	2009-09-21 11:37:50	2009-09-21 12:37:50	3	3	243	90	207	367	0	37.50	38	13.88	CHANGED	sNc+up+ptsY+atpGTTuVLscpl..hpl-lscp.pVps	..............sNp+sp+..ptpY+atpGTTAVLscpl..hpl-.lh-E.pVp.................	0	55	93	153
+12300	PF12466	GDH_N		Glutamate dehydrogenase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF05088.  There is a conserved ALR sequence motif. Glutamate dehydrogenase (GDH) is a homohexameric, mitochondrial enzyme that reversibly catalyses the oxidative deamination of L-glutamate to 2-oxoglutarate using either NADP(H) or NAD(H) with comparable efficacy.	25.00	25.00	25.80	38.20	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.85	0.72	-3.98	4	31	2009-09-21 11:39:53	2009-09-21 12:39:53	3	1	30	0	6	34	2	55.10	60	3.31	CHANGED	MpupKuASpSspsssKPsAEpuVsssAp..ptloLEPVFAALRKRYPAAtQuEVQtFAAD	.....MsuKKuhSpSspsssKssAcpulsshAp..puVoLEPVFAALRKRYPAAtQuEVQtFAAD.	0	1	3	4
+12301	PF12467	CMV_1a		Cucumber mosaic virus 1a protein family	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is typically between 156 and 171 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01660. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein.	25.00	25.00	43.70	42.60	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.12	0.71	-3.90	14	89	2009-09-21 12:27:24	2009-09-21 13:27:24	3	3	22	0	0	90	0	156.90	59	16.17	CHANGED	Whusho+sh..RsFlpshlpohFPoLR....+DcpEFLsKLSshsoF.NEpspsDhucphDVhusAAsl.......sshsVpsuKphts-KcKpht.stppPV.p.s.t.............s.ssc.sPtsssssps...spssp.pslospTcss-oRlApRusAMhEYssYpppLHsNsVSNL	.......WFAuhTRPl..RVFFSoV.V+sLFPTLR...PREEKEFLlKLSTFVTF.NEECSFDGGEEWDVISSAAaV.......AsQAVsDGKlLAupKAcKLA-+LApPV.ElSsp...............s.ssSsTPcDsussCG.cEpEsSELDSLSuQTRSPITRlAERATAMLEYuAYEKQLHDTTVSNL	0	0	0	0
+12302	PF12468	TTSSLRR		Type III secretion system leucine rich repeat protein  	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. There are two completely conserved residues (Y and W) that may be functionally important. This family consists of leucine-rich repeat proteins involved in type III secretion.	21.20	21.20	23.00	21.80	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.31	0.72	-4.42	25	427	2009-09-21 12:29:20	2009-09-21 13:29:20	3	37	178	4	17	313	0	45.10	35	7.66	CHANGED	shuhsssSh.st.......tssposs-YculWscWc+sAsss..EpRspAVp	...................t..psS...t......sssspssssYhslWs-Wc+pAsst..EpRppAVp......	0	0	7	9
+12303	PF12469	DUF3692		CRISPR-associated protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is typically between 101 and 138 amino acids in length. The proteins in this family are frequently annotated as CRISPR-associated proteins however there is little accompanying literature to confirm this.	21.90	21.90	22.80	23.10	20.50	21.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.54	0.71	-3.87	86	200	2009-09-21 12:31:19	2009-09-21 13:31:19	3	1	170	3	93	221	4	122.50	24	16.65	CHANGED	hllsloluPVQsFIspuR+s+DLWuGSalLShLstpshptl..hcp.............sst....llhP......t................t.................................................httsl.P.....................Nphhhhlsstt................hpthtcp......................scpshpctac..plscpl	.....llhholuPVQsFIspuR+s+DLWuGSalLShLsttshptl..hcp.t...........sss......llaP.......s.hptp........h...hhpphtt......................................................tsuh.P.....................................N+hhhh..lsssp................hpthtpp...................scpthpptapplhp..h......................................................................................................................................................	0	56	74	85
+12304	PF12470	SUFU_C		Suppressor of Fused Gli/Ci N terminal binding domain	Gavin OL	lg7	Manual	Family	This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with Pfam:PF05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologues. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologues.	25.00	25.00	32.70	28.80	23.70	22.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.18	0.71	-4.72	6	111	2009-09-21 13:09:09	2009-09-21 14:09:09	3	6	78	4	67	106	0	191.20	52	43.07	CHANGED	hcpl-cslE+-GSsLuGVsAchsacELs+ss.scp.sc.............cpsT-p.ppshpcshphppcus.sss.uppssshpps.............sshshspphsRspsLsGlcLphu.puAphLsLAlRsRlRHGRHFTF..pspchAlTFVopuVsGuhsoc-cPYushGsWlQILIss-hV.+Ml--hpDLooscs..LKlPhpYcWP-+sLKlhl	................................................................E+V-cGIEp-GSNLSGVSAKCsW--LocssEcc--ocshslup..........................................tp-TE.QIREsLp+GLchsscPlhP.slss.p+pNuhp+s........................ppsssshlPpELlR...TRpL-uVHLKFNtEuGuLlPLs..lRGRLhHGRHFTa.KS.IsGDhAITFVSoGVEGAFATEEHPYAA+GPWLQlLls-EhVp+MhcD....hp.sLsss-c.......hphPhpapWP-+pLpl.l.................................	0	20	24	45
+12305	PF12471	GTP_CH_N		GTP cyclohydrolase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. This family is the N terminal of GTP cyclohydrolase, the rate limiting enzyme in the synthesis of tetrahydrobiopterin.	25.00	25.00	50.80	35.80	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.23	0.71	-4.70	39	190	2009-09-21 15:39:55	2009-09-21 16:39:55	3	7	177	0	131	193	27	187.10	54	40.49	CHANGED	hss+IhLToaPsptshsPlPlpWGA.ssstcRGPVlso..hsshs+RNAIGsHuGSYulY+ALAVAuGpLsscH+sDhTNTpPshsIsPpPpWuDPpKIVShDPaGHlssphFschh.ppGhDIRPTIAlT+AHlplsElp-AlppGRLtsDGcllhs.................sG-ltVTKsAlEPVWYLPGVAcRFGlsEstLRRsLFEc	................h.s+IlLToaPsp.t..uhs.PlslcWGu.ssstpRGPVlso..ssshp+RNAIG...............uHuGSYSlYpALAVAuGtLss-HRPDhTNTpPsssIGPaPpWuDspKIVShDPWGHhlsphFtc.l..ppGl..DIRPTIAlT+A...HhpLPElp-AlppGR.....LhsDG+llls.....................................sG-lsVTKsAVEPVWYLPGVA-RFGlsEusLRRsLFEp.....	0	40	75	109
+12306	PF12472	DUF3693		Phage related protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is approximately 60 amino acids in length.	21.00	21.00	21.10	21.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.72	0.72	-4.37	31	83	2009-09-21 15:41:09	2009-09-21 16:41:09	3	4	62	0	13	83	0	55.90	28	40.57	CHANGED	lltl+u-+uco.pt+shWpsIhK+hsuhuhs......sluhs.hsuhuhuhststpslspssls	......LlslcA-+ucsspt+shWpsIsKKhsuhuhs......sluhs..hsuhuhshstsppslhpssl....................	0	3	7	9
+12307	PF12473	DUF3694		Kinesin protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 131 and 151 amino acids in length. The family is found in association with Pfam:PF00225, Pfam:PF00498. There is a single completely conserved residue W that may be functionally important.	21.80	21.80	21.90	22.20	20.60	21.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.76	0.71	-4.52	38	863	2009-09-21 15:44:23	2009-09-21 16:44:23	3	52	182	0	460	731	1	128.10	25	11.09	CHANGED	pYhPV.h.pssp...s.GsFpL+QGlp+Rlslslsppsupph....hpchhtlhluth+.h..ss..h........s..h.Lpl.lspt.......ss......................................shshhupWDSShH.sShhLNRhT.sppp+lhlTlshslhhsc.hscPlhFph-lslpIh.uRsth	.............................................................pahPs.h.pttt.....s.shF.L+Q...G.h.p++lslpl.pp.ps.s.ph................hcch.h.tlhl.....u.hp...........................s....h..htlhstp.................ps.........................................................................................................................................hphpusWDouhH.sp.hLNc.T..s..................s..c+l.ahtlts.l.............lpp.s.........hhhphchsh.hhsppt.t..............................................	0	114	158	301
+12308	PF12474	PKK		Polo kinase kinase 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.	25.00	25.00	27.80	25.70	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.08	0.71	-4.46	23	413	2009-09-21 15:49:36	2009-09-21 16:49:36	3	10	84	0	193	333	0	135.60	35	24.19	CHANGED	+aplt+cQh+cpFh.p+ppLh++a-p.ElEplpRhppcplEchcpcQptE++chsKplRsEpcpchthF+-SL+lptp...pscp-hE+l...cpQc+cchKtc+pchppKHppp.c-hhuppcsslcp.Lpplpsc+++tLh..EpE	.........KcQht+pQl+cpa..pppphh+pa-p.EhEphpRhppphlEcLcpcQsp-++c.sKphR....uEtcpchuhF+csL+hppp.....psp...........p-h-+.l....p.pQcccp.K..p.c+.p.ppK+p.p.p.+-hhtppcps....lct............Lpplps...c+p+.Ls-pE.................	0	43	63	120
+12309	PF12475	Amdo_NSP		Amdovirus non-structural protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 50 amino acids in length. This family contains proteins of each of the four types of Amdovirus non-structural protein.	25.00	25.00	40.50	39.70	19.40	17.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.36	0.72	-4.06	7	138	2009-09-21 15:51:29	2009-09-21 16:51:29	3	3	3	0	0	147	0	46.60	63	33.50	CHANGED	YhDKspcPpcsp.sL....+phspDLtlhaoshcCshps.p-scscsp	.FDKNEDPKDVpKSLGWhlK+LN+DLA.lIaSNHHCD.QsIKDPEs+Ac......	0	0	0	0
+12310	PF12476	DUF3696		Protein of unknown function (DUF3696)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length.	21.70	21.70	22.60	21.70	21.60	20.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.55	0.72	-3.99	58	201	2009-09-21 15:55:04	2009-09-21 16:55:04	3	4	191	0	67	169	38	49.90	25	12.02	CHANGED	lsscclulaah.....ppspttsplpplp.lscpGcl..spWP.....cGFFDphttph.pLh	............................ppltlhah.....ppssssoplpplp.lsppGpl..spWP.....cGFFDpt.h-h..h.............	0	26	46	57
+12311	PF12477	TraW_N		Sex factor F TraW protein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. The traW gene of the E. coli K-12 sex factor, F, encodes one of the numerous proteins required for conjugative transfer of this plasmid.	21.30	21.30	21.80	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.03	0.72	-3.91	21	169	2009-09-21 15:57:01	2009-09-21 16:57:01	3	1	137	0	29	121	8	30.20	55	14.12	CHANGED	hhhhhlhshlhhussApApsLGshGssaPIu	......hpspuLlALLlaGQS.VsAADLGTWGDLWPV.p.	0	5	12	24
+12312	PF12478	DUF3697		Ubiquitin-associated protein 2 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00627. There are two conserved sequence motifs: AVEMPG and QFG.	22.20	22.20	23.10	23.00	21.50	19.70	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.51	0.72	-4.31	7	185	2009-09-21 15:58:24	2009-09-21 16:58:24	3	3	70	0	80	193	0	33.20	77	3.25	CHANGED	.sopIPuoAVEMPGuu..slsuLslQFGAL-FGSE	..PsSKIPAoAVEMPGSA.....DloGLNlQFGAL-FGSE......	0	15	21	45
+12313	PF12479	DUF3698		Protein of unknown function (DUF3698) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 89 and 105 amino acids in length.	25.00	25.00	34.50	34.40	24.70	22.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.48	0.72	-3.95	11	45	2009-09-21 15:59:39	2009-09-21 16:59:39	3	3	1	\N	45	47	0	98.90	31	34.17	CHANGED	TltsGITLRSA.IAGFFYpsEs-uh-Tppphtpsasl.upKT.....ppsDPhhNVhP+shcps.....sh+..p.t........s.hhsltEsssp-.aps.....IcssTas	............hlcssls.h+sh.hsshhahspscu.soppp.thsFuI.shKTt.h.hppu...hplt.cs.ppp..phpphR.opp.s...............hushlhht.shpp..apA......Rs.h............	0	0	45	45
+12314	PF12480	DUF3699		Protein of unknown function (DUF3699) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length.	20.40	20.40	21.20	21.70	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.27	0.72	-4.34	17	310	2009-09-21 16:01:11	2009-09-21 17:01:11	3	9	30	0	145	276	1	75.50	33	13.82	CHANGED	tss.slpLophlPLph..VclplHstpphpLcl+hsouRsaYLpLsssscp.-slFstWl+Llp...lLp.shpthspsspl	...................t..s.plpLo...RhLPL+F..VcLplaDpppppL+l+hsT......sRsaYLp.Lsssscp.-slFshWh+Ll....lLp.shsthsps.t............	0	10	12	26
+12315	PF12481	DUF3700		Aluminium induced protein 	Gavin OL	lg7	Prosite	Domain	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: YGL and LRDR. This family is related to GATase enzyme domains.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.46	0.70	-5.15	33	220	2012-10-03 21:14:07	2009-09-21 17:03:10	3	4	52	0	86	1785	730	191.40	46	86.72	CHANGED	LAlFcKulAcsP-ELpS.Psss.s.usth............................c...............ssptllpcFhSspP.suholshGs..uuhlAYotspps.....slhPRLFush.DDIaClF.GpL-NLssL+pQYGL.uKssNEshlVIEAYRTLRDRGPYPADQVV+-LpGpFAFVlaD.spssolFsAsDsDGpVPLaWGlsADGslVhSDDh-llKtuCGKSaAPFPp.GChFoSs.GGLpSFEHPhN+lKu...........hP......RlDSE...G.hC..........GAsFKV	.......................................................................................................LulFpttlspsPptL.u.st.t.........p.sttlhppFhstts..suhohphGs...uhhA..a...ot....tpps.......hp..R.Fush.D.-.Ia.C.l.F.GtL-NL....u....t....L.......p....p.....Q......Y....G.....L....u...K....s...s..N.....E....sh....h.VI.E.A.Y.+T..L.R...DR.u...P.....Y..P..A...sp.......V....lpcL...pG..pFAFVl.aDsp.......s.....p..olF.sA.t................sss.G.p....VsLa..WG.l..s............u.......D..G...p...l.shS..D....-.h....-...l..l.......K.....t.....u...C.u.K..S.hAP....F.Pp.G.Ch.apot.....uG.....L.......p...S...a.Ep..Ph..N+.l.pshPth-pc..hCGusFKV............................................................	0	12	61	73
+12316	PF12482	DUF3701		Phage integrase protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00589.	21.50	21.50	21.60	28.90	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.28	0.72	-4.24	38	151	2009-09-21 16:05:01	2009-09-21 17:05:01	3	5	74	0	61	147	10	96.20	37	16.67	CHANGED	ptLcshs....sssPthsDslstWLssplstsLputGIp.......TLu-LssRlsRRt.+WWpulPGLGssuARpIEAFhAsHsslst+u.....................psllhhs.pusllP...h	.........t..LcphssssPthsDsVshWLs..spss..tsLpAtGIp.......TLu-LssRlsRRt.pWWpulsGLGsuuARpIEAFhusHsshst+s..............puhlsh..ps.lsP.................................	0	3	11	45
+12317	PF12483	GIDE		E3 Ubiquitin ligase	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.	21.20	21.20	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.87	0.71	-4.87	31	280	2009-09-21 16:07:55	2009-09-21 17:07:55	3	6	190	0	162	283	43	144.10	22	45.07	CHANGED	ppphtccppp......hhpppochlspspcpsPFhLcD....s...........o.GcVhV..s.suutlshhhshcp.F....cs.ss.stsshthuhh..th.....................slGh+hhEclLPsspplhVlGps.pDstG..lpIppPppt.....FhlS.coc-pLhpphtpts+hhhhuulsh.......sllG	..............................................t....thhppppchlp.ptsp.psP.Fh...L...p..D...s.................s..stVhV..s..s.u.ss.l..s..l..p..sshcp.a......c.sst..shss.hh.hs.hhsutp.....................................hG..h..p.psEchL.sGssloslG-h..................h....tc.......s.....st....lp......l.p...sppt...........ah......l..o...s.pplhtp.tt.hphh.hhhshhh..h.......shhh.................................................................	0	44	89	131
+12318	PF12484	PE_PPE_C		Polymorphic PE/PPE proteins C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00823.  There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.	21.80	21.80	22.10	22.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.16	0.72	-3.05	86	1529	2009-09-21 16:10:05	2009-09-21 17:10:05	3	5	63	0	165	799	0	84.80	32	22.29	CHANGED	V.uAu.l...GpAusl.GsLSVPsoWusu.....sPsssssus..........Lsssshssssssss.......sssh...h..GhP.........hsuhuutttsu..hs...........sRYGh........Rss..VMs.R....PP	.....VuAul.Gp.Au.sV.G.sLS.VPsuWusu........sP.u....s.sssuss.........lsssshsussssus.........ssh....hs..GhP.....huuhuu..t.usuu..su..................RhGh.....+.hVhs.+...........................................................	1	35	69	134
+12319	PF12485	SLY		Lymphocyte signaling adaptor protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with Pfam:PF07647, Pfam:PF07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.	25.00	25.00	59.20	59.20	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.16	0.71	-3.98	14	178	2009-09-22 08:22:33	2009-09-22 09:22:33	3	9	39	0	84	140	0	148.20	42	25.16	CHANGED	c.p.pRSoSFGcFct.+..sSPlps-cchsscpt......tttsscsssp...SuhsLGKK.h+u.IShTM++KMGKch.KAlSEEhs-ss-tcshssssss...t...h-Kssl+uusShESLaS.hSGQSSoSu.sVsSsSsGsSNRDSl+LE....-psP..YsGPF	......................................phtRS.oSFGsFDtp+.spS..ssps-cphpsc-s..h......htts.csssp...Su.tuLGKK.h+u.IScTM+KKMuKKY.K.uLSE-ht...-sst.tsuhssss.ssst.-s.ph-KssLKuusShESLhsshSGQSSoSu.sloSsssGo..SNR-..Sh+.E....--sP..YsGPF................	0	3	10	33
+12320	PF12486	DUF3702		ImpA domain protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 207 and 469 amino acids in length. The family is found in association with Pfam:PF06812.	25.80	25.80	31.70	31.50	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.86	0.71	-4.53	26	515	2009-09-22 08:23:51	2009-09-22 09:23:51	3	2	347	0	39	278	0	138.20	40	33.88	CHANGED	hppQLspLpplsPhaslphGppllcpApplWPss.phpthsppWppplpspAhsssplsuWpputspLppLu-+Lsth-cp+Gp.hTlS.LKoslashppsh.spshPlEEhLRQLptp.tpspsss.uhhppl-p+LptLLsRYhhLpp	...............pppLpQLhchsPl.sLcpGhphh+.AcshWP-s.Q.pphsspWpctlcspAtsss.pLpGWhQsppcLcthA-hl.phEcct...lTlS.lKoslaphcpuL.spE.sP.lEpLLpQhp-s.+s.pppsss.sLpKQIspRLptlLuRahlLpp.......................	0	0	10	19
+12321	PF12487	DUF3703		Protein of unknown function (DUF3703) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length.	21.10	21.10	21.70	21.20	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.49	0.71	-4.40	51	103	2009-09-22 08:25:31	2009-09-22 09:25:31	3	5	84	0	62	114	13	106.70	36	81.37	CHANGED	hsppl+thaptEhptAcps.ttushstsWpHLERAHIluQ.hshhHstsHhtMLthuh+p+DtREshGQllRllsussGShhG+hPhGNTGtusVushpPMPlPpDLtsllp	...............ppl+thaptEhptupps.ttsshptuapaLERAHIluQthshh...Hs....psHhtMLphuh+p+Dt+EshGQlhRllsus..stohhGhlPhGNTGtusVushpPMPlPp-Lttll.s......	0	17	34	50
+12322	PF12488	DUF3704		Protein of unknown function (DUF3704) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length.	21.90	21.90	22.80	22.30	19.50	17.70	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-6.78	0.72	-4.32	8	22	2009-09-22 08:30:11	2009-09-22 09:30:11	3	2	7	0	16	27	0	27.10	65	20.88	CHANGED	hL.VG.......ASaGYMP+ssIAGSSsSshSNF	..hLPVG.......sSSGYMPRRGIAGSSuSoMSNF..	0	0	1	16
+12323	PF12489	ARA70		Nuclear coactivator	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.	22.10	22.10	23.50	30.80	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.96	0.71	-4.19	17	169	2009-09-22 08:56:56	2009-09-22 09:56:56	3	2	39	1	59	142	0	127.10	39	44.89	CHANGED	spspLp-.hhts+sthtsp..t.h.s.pshpsWL.....lhpphpppohp.pttph....pphhGphpsL.p.L.p................spops.ssphShphp+lusLsLpspEs................ochLhpssshphhpphsshG.hpspppch+.hh	.............................t.plp-.LhtsKst.tsp..t.h.s.pshps....WL......h.hQh.pEp...o......pu..pph.......lhGphpsLpp.L.p................sps+shssphSlphE+lusLpLhspDp................oshLhpsspsthhpp.sshu..cshp...+hh..............................	0	3	7	21
+12324	PF12490	BCAS3		Breast carcinoma amplified sequence 3 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.	21.70	21.70	21.80	22.40	19.00	20.40	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.68	0.70	-5.07	19	188	2009-09-22 09:23:55	2009-09-22 10:23:55	3	6	103	0	117	200	0	227.20	26	26.76	CHANGED	PsPloLoVVSRIKsus.sGW..........tsoVs...sAAuoA.oG.+sshhuGAlAusFH.....ss..hstsspsssst.sssh-pLhVasPoGpll.QYhLcPusus....pss.t.shsptsthpp.......s-l+lhVEslppWslsR+ssh.Ep--.phsshstsspts..h..hhtssssct..............p.tts.pt........phpscEppchalSpAE.lphapsp.hPlWtcschpFpsh.ssps.p.p....ts.hu........sEhEI..EclsscplEhRpK-LlP	...........................................................................hsl.slupIKps..hGh..........................................h...p.........phusu...t..oh.t.hsluushusshp.........ss....hppptsppp..p.hsl-pLhlhos.GsLl.pahLcPpshs................ssp..hs--..............................oslclhspPhtpWslsRp.ph..-hps....shstsp.hhh.t............th.......................s.....thssht....................................sscstpccc..WLSplE.lhTHsGP...t+.LWhsPQ.......FpF+shp.sss.psh.....sss.u......................................................................	0	36	62	91
+12325	PF12491	ApoB100_C		Apolipoprotein B100 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. There are two conserved sequence motifs: QLS and LIDL. ApoB100 has an essential role in the assembly and secretion of triglyceride-rich lipoproteins and lipids transport.	21.20	21.20	21.20	38.90	21.00	18.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.76	0.72	-4.33	4	81	2009-09-22 09:27:57	2009-09-22 10:27:57	3	4	63	0	21	76	0	44.40	75	2.02	CHANGED	Qh+hKLQDFSDQLSDYYEKFIAEocRLIDLSIQpYHhFL+YIhELLKcLQssTssshh	..QFRYKLQDF.DQLSDYYEKFIsESKR....................................	0	1	2	7
+12327	PF12493	DUF3709		Protein of unknown function (DUF3709)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. There are two conserved sequence motifs: RCLMK and LIEL.	21.20	21.20	21.20	21.20	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.87	0.72	-4.25	9	226	2009-09-22 12:07:19	2009-09-22 13:07:19	3	2	48	0	7	117	0	29.50	76	37.05	CHANGED	hRCLMKpQCVCRCKFQpaCLIEL.psCVVSpFV	...hRCLMKRQCVCRCKFQpaCLIELSp.CVVS.FV.......	0	7	7	7
+12328	PF12494	DUF3695		Protein of unknown function (DUF3695) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 157 and 192 amino acids in length. There is a single completely conserved residue D that may be functionally important.	20.30	20.30	22.00	37.20	19.00	16.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.35	0.72	-4.29	14	77	2009-09-22 12:08:13	2009-09-22 13:08:13	3	3	63	0	46	79	0	102.70	35	46.11	CHANGED	.ssappss+hupp.cPapRLa.ptThuSsRRsstahs......................sphPpDSLDFpLpotYDHpc-hFhsKs-sllQpETlst...................tphRhL+Nst.h.p..pDsl....t+PL+l	................t.satpss+hspp.-PapRLpspsTlsShRRsshahc......................PpIP+DsLDFpLsulYsHHsshFpsKs-lLlppEThpc...................pp.h.p.hlp.stchh....ss............................................	0	16	19	30
+12329	PF12495	Vip3A_N		Vegetative insecticide protein 3A N terminal 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 170 and 789 amino acids in length. The family is found in association with Pfam:PF02018. Vip3A represents a novel class of proteins insecticidal to lepidopteran insect larvae.	25.00	25.00	85.90	85.40	21.30	20.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.24	0.71	-4.59	12	67	2009-09-22 12:19:40	2009-09-22 13:19:40	3	2	11	0	0	62	0	166.50	96	26.51	CHANGED	ALPSFIDYFNGIYGFATGIKDIMNMIFKTDT.GGsLTLDEILKNQQLLN-ISGKLDGVNGSLNDLIAQGNLNTELSKEILKIANEQNQVLNDVNNKLDAINTML+lYLPKITSMLSDVMKQNYALSLQIEYLSKQLQEISDKLDIINVNVLINSTLTEITPAYQRIKYVNEKFEELTF	....ALPSFIDYFNGIYGFATGIKDIMNMIFKTDT.GGDLTLDEILKNQQLLNDISGKLDGVNGSLNDLIAQGNLNTELSKEILKIANEQNQVLNDVNNKLDAINTMLRVYLPKITSMLSDVMKQNYALSLQIEYLSKQLQEISDKLDIINVNVLINSTLTEITPAYQRIKYVNEKFEELTF.	1	0	0	0
+12330	PF12496	BNIP2		Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.	27.00	27.00	29.50	29.50	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-11.01	0.71	-3.97	17	319	2009-09-22 12:21:50	2009-09-22 13:21:50	3	8	68	0	141	251	1	129.20	46	19.61	CHANGED	cpp+++LsAPp..........................................lsLoL.DpS..................................................................EtShhSD-h.-oss-.........lDls.....lDDL..DTPs-sD.h-h.s...-h-............WEDDhPts.pusptssps...l.phos-.EEcpDs.RhWRslhIG-.QE+RIDM+lIEPYp+VISHGGY.YG-G	..................................................................................................................................................................................................................................................................................................................................................p..hR++LsAPp............................................lsLoL..DtS.....................................................................................-GSlLSDDh.-o.....s...................................Dls..........lD-l..-TPsEs-ph-...s.......ch-.............WE..DDhP..ps..p.sss..tc.......hs-ho...u..-...E.E.p.cDs..RhWRshhIGE..QEpR..lDM+sIEPY++VlSHG.G...Y.YG-G..........................	0	19	31	67
+12331	PF12497	ERbeta_N		Estrogen receptor beta	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00104, Pfam:PF00105. There is a conserved IPS sequence motif.  There are two completely conserved residues (Y and W) that may be functionally important. ERbeta binds estrogens with an affinity similar to that of ERalpha, and activates expression of reporter genes containing estrogen response elements in an estrogen-dependent manner. ERbeta acts as a transcription factor once bound to its ligand and it can dimerise with ERalpha.	25.00	25.00	27.50	27.50	22.20	17.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.64	0.72	-4.22	29	224	2009-09-22 12:23:36	2009-09-22 13:23:36	3	4	124	0	31	209	0	107.90	43	20.22	CHANGED	sPhhhS...ssLsh-.spslCIPSPYsDtuHDas..........slsFYSP...olh...uYut.Pulo-sPo...l+poLSPSlFWPuHuH..hssLsLHs.sQshshp-t.spoPWsEhps..-pslssSppsl	...........Ps.Ys...s.LshE.ptsIhIPSsYs-spH-Ys..........sh.sFYSP...ulhsYu...h.Pu...s...sssss....s+QohSPslhWPo.GH....lSsLslHp.ppuhlY.sEs..+SPWsEs+s.h-Hs.Ls.spps.h....................	0	1	4	12
+12332	PF12498	bZIP_C		Basic leucine-zipper C terminal	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 174 and 411 amino acids in length. The family is found in association with Pfam:PF00170. There is a conserved KVK sequence motif. There is a single completely conserved residue K that may be functionally important. Various bZIP proteins have been found and shown to play a role in seed-specific gene expression. bZIP binds to the alpha-globulin gene promoter, but not to promoters of other major storage genes such as glutelin, prolamin and albumin.	22.70	22.70	22.80	24.60	21.60	22.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.78	0.71	-2.85	28	167	2009-09-22 12:46:35	2009-09-22 13:46:35	3	3	36	0	44	171	0	111.40	34	37.25	CHANGED	TLRAKVKMAE-oVKRlTGhsshh.sh..phsohshs..ss.Ss.ts...sssPhQsssppaat.pssss.shs.........................tptsst.su.shsuschsposuh....p+lA.....uLE.alQ+.RhpuGsssss	.............................TLRAKVKMuEDolKRVhthss.........o.Shshsh.ss.Sss..s..sssPlpDshssaFs.s...sssssshssts....................t.psss.shsu.shsus...cMspsuu...h....p+sA.....uhE.hlQp.thtuh.sss.u..........................	0	7	30	38
+12333	PF12499	DUF3707		Pherophorin 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 147 and 160 amino acids in length. The proteins in this family are frequently annotated as pherophorins however there is little accompanying literature to confirm this.	20.60	20.60	20.70	20.70	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.70	0.71	-3.87	78	350	2009-09-22 12:49:21	2009-09-22 13:49:21	3	15	4	0	307	345	0	144.00	20	42.98	CHANGED	FP...hC........ppstssoPapl....shsssstss.........................................spaCFslpss.........s.ssss....sCC.sss.....LpK..lEhhs.........s....ss..stpssl....sGhsstssssstps.s...s...........sL..................+l....ssLs.hshspssuu.....plCls.lp.................sssolsplC...............sss..sCthu.................................ps..C......CP	............................................................P....p.....pppp.t...sP.apl......s.s.tstss.........................................spaCFplpsh...................................ssssss......sCC..sss.....lpK..lEh.sss..............sC..p....sslt.sssl........sG.h..sthth.t..t.h.t...s........................sl............................+l.ssLs...hshs..pssuu..........plClp.lp..................sssolpphC...................sss...hC.hs.hhs..................tstpC..CP................................................................................	0	97	307	307
+12334	PF12500	TRSP	DUF3706;	TRSP domain C terminus to PRTase_2 	Anantharaman V, Gavin OL	lg7	Anantharaman V	Domain	This domain occurs C terminus to PRTase_2 and has a highly conserved GXXE and TRSP signatures [1]. It is found in bacteria.  These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	25.00	25.00	58.20	33.50	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.21	0.71	-4.75	67	331	2012-10-09 19:35:50	2009-09-22 13:50:58	3	6	324	0	70	262	6	151.80	33	34.43	CHANGED	hstsss...............................................ts...................................hshtsptsa........................GRhGhpssp....s........h....shutp.lphtt......................................c+lLVLGTsEFhahPhhlAcpLppth.............s..VhapSTTRSPIts.....GYAIcsulsFss...s.s.sl.........NalYNVs.............tt.............................................aDc....lllssEs............ssss.s........ssLlptL	...................................ssstt.h.htsttsh.......................................GRhGhhs.t...t.......h.clucplpstt......................s.c+lLVLGTuEFhatPhhLAccLEptu................s..plhapSTTRSPIts......GYAIcssluFsssY.shul........sNalYNVs.t........tp......................................................aDc.lllssEosscshs........stLlptL..............................	0	20	44	60
+12335	PF12501	DUF3708		Phosphate ATP-binding cassette transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 143 and 173 amino acids in length. The family is found in association with Pfam:PF00528. There is a single completely conserved residue P that may be functionally important.	21.70	21.70	21.70	21.70	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.00	0.71	-4.41	84	285	2009-09-22 12:53:06	2009-09-22 13:53:06	3	3	283	0	89	250	468	152.80	29	32.47	CHANGED	lll.lllhLushuahhGRpRAhsh......u..sus.t....LHSLPsYYGhhlAlasslPAlllLslWhhh....pPhllpphVhuplP.......sstshsssphsL........lhucl+slApG................................thslsups.....ssthhsAAppapshpstuphhhssllls..lAluGhsa	......h.ll.hllsluhluahlGRpRAhsl......A.t.GssstplHShPsYaGhaluLhsulPALllLslWsls....pshhlpp.lhuplP.......tst.hstsptsL........hhuplcslAsG.............................................hslusps......pshhlshApthpphpshsphhhsslsls...lAluGhh..........................................	0	30	62	74
+12336	PF12502	DUF3710		Protein of unknown function (DUF3710) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 284 amino acids in length. There are two conserved sequence motifs: DLG and DGPRW.	25.00	25.00	54.70	54.60	19.40	18.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.07	0.71	-4.96	59	439	2009-09-22 13:18:44	2009-09-22 14:18:44	3	1	430	0	116	319	51	179.10	38	69.44	CHANGED	GPaDhtpsp......sssssstlDLGulhlPhspGhplplEhs......ps.tt...shulplshspuplpltAFAAP+osGLWcElRtElspulppp.G...........upspt.psGsaGtElhuph.h............................sssh.tshRhlGVDGPRWhLRuVlsGsu...utssp....tAthlcclhppsVVsRGspPhPsR-sLPlp...LPpphs...pphtts	...............GPaDls-hs......ssssssRlDLGSlhlPhhcuhplplchs.........ps.Gs...spulhllpssutlplsAFA.AP+o.....s.....GlWcEVppEl..scuhptp.G............upssh.tsGPaGtElhshl.h...................................................tG..tsu...tssRhlGVDGP.RWhLRuVlsG.u.......uhscp............tuphlc...-hhsshVVcRG-sPhssR-slPlc...lPpshttt....s....................	0	34	84	108
+12337	PF12503	CMV_1a_C		Cucumber mosaic virus 1a protein C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01660. There is a conserved GLG sequence motif. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein.	25.00	25.00	32.20	110.20	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.01	0.72	-4.26	11	89	2009-09-22 13:36:50	2009-09-22 14:36:50	3	3	22	0	0	90	0	88.00	68	9.08	CHANGED	RlWshAGGcscsss.cS....Vh-TY+pVDshVNlHassGpWha..PpthcYoVGYN-pGLGPKh-sELYIVspsCVIuNscsLAcuoc	.RIWsMAGGDsKRNSLEGNLKFVFDTYFoVDPMVNlHFuTGRWM+PVPEGlVYSVGYNE+GLGPKtDuELYIVNu-CVIsNS-uLSslT.+.	0	0	0	0
+12339	PF12505	DUF3712		Protein of unknown function (DUF3712)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 130 amino acids in length.	21.60	21.60	21.90	22.20	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.67	0.71	-4.10	72	289	2009-09-22 13:43:24	2009-09-22 14:43:24	3	10	90	0	237	309	1	125.60	19	24.44	CHANGED	sshupltlsthph..sst......shhh.hspphtlsshs......saspaspsllhpcp.hslslpGp...s.p..hphGsl..shpslsh.sKslshp....................G................Lsphp.uhs.................lsshplhhss....ts.........GhNh.husshl....................sNPSslol.pl..G.......slolsl	...........................................................hh.h.hs.hph..t.t........t..h.hst.lplsshs.......sFspa.....sptlh..tspp..hslpl.p.up......s..p.sp....husl...thpslsh.s+slslp....................G................h..ss.hp..uhs...................lsshclstss.....ts....................................uh.sh.pus.ssl....................sNPSs...hol.sl..Gslshp...................	1	97	152	213
+12340	PF12506	DUF3713		Protein of unknown function (DUF3713)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 92 and 1225 amino acids in length. There is a single completely conserved residue S that may be functionally important.	21.90	21.90	21.90	37.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.57	0.71	-4.02	10	36	2009-09-22 13:46:33	2009-09-22 14:46:33	3	1	8	0	10	38	0	97.20	36	13.00	CHANGED	cLssYF..p.lIsc...sKVsscso.........soocpss.sclhTpst-......lcKl+-c.pscl-sKlccaV.sKLKsostPpssYSplILlsspsD....pshossu.huLhuLlslposs.LsNtl++paFssss	.cLspYY..cslI.....sKVuspso.........sospsosssph..pptp......lcKL+-p.Kccl-stlKcaV.scLKlol......Sp.h.lp.p.........p....h...s..t....p.....hh..hh.ps..	0	7	7	7
+12341	PF12507	HCMV_UL139		Human Cytomegalovirus UL139 protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes and viruses. Proteins in this family are approximately 140 amino acids in length. UL139 product shared sequence homology with human CD24, a signal transducer modulating B-cell activation responses, and the sequences in the G1c variant of UL139 contained a specific attachment site of prokaryotic membrane lipoprotein lipid.	25.00	25.00	25.20	35.00	24.10	24.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.53	0.71	-3.95	8	69	2009-09-22 13:50:58	2009-09-22 14:50:58	3	1	17	0	13	66	0	103.10	56	63.02	CHANGED	hs.hpuppphpls+splLAu........pLhhlhohphpCahLhRKlh....................................................psspGpspEtEp+ppchtRahps+tsp.sshhshussh.Sho.s.Qssohts.sp	...Clpu.uGosWsssQLALLAASGW..TLSGLLLLFTCCFCCFWLVRKI.....................................................CSCCGNSSESESKsTH..AYTNAAFTSSDATLPMGTTG.SYTPP.QDGSFPPPPR.	0	1	7	10
+12342	PF12508	DUF3714		Protein of unknown function (DUF3714) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 200 amino acids in length.	20.90	20.90	23.00	22.50	18.40	17.60	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.85	0.71	-4.85	44	464	2009-09-22 14:34:16	2009-09-22 15:34:16	3	4	143	0	56	408	7	192.20	34	48.13	CHANGED	cshshssptsppphssshtp.hs-..pshhssh.spspsttFpThstsp....ppNsIpAslcpspTl..ssGspl+lRLLEshtl.ssthlP+sThLhG.suphpGpRlplpIsSlphsGsIlPVcLsVYDs.DG.pGlaVPsShct-ssKEhuushssuh.....ssshshup.suusQlusshupuslQusSphluK+hRplKVpLKuGap	...........................................................t......ht..pcphlosLt.pshss...tthhtth.sptpshsF...pTssusst......pcNoIpAslcps....p.sl..p-GppV+LRLLEsh..pl....sshhI..P+sohlhG.su+lpG..pRlclpIsSlch.sGpIlPVcLulYDs.D...GQcGlalP..s....S.-hs.As+EluAshuuuh......soShshus..sAss....Qlus-hs+ulhQGsSphluKKhRplKVpLKuGYp..........................................	0	18	48	56
+12343	PF12509	DUF3715		Protein of unknown function (DUF3715)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 170 amino acids in length.	20.90	20.90	25.40	22.00	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.94	0.71	-4.39	12	131	2009-09-22 15:00:10	2009-09-22 16:00:10	3	11	42	0	67	140	0	157.60	27	12.42	CHANGED	lpNphLppcastpR..pph+pct+pscEL.-shsFLhhcs.tcstsl......s.........ppGLpss...puKsshLGcsphGVhls..RhuDlhpppshpsu...shs.lhlhKlh+G+hKpl.-s..........spstlsPsPsa-sHl......uc.shsplssphh...ta.pothYhhEh...shs.shhcPpphhP	..............ps.hLppphoppc..pphthstpsspEL.Es.s..hL..hcp.hpsppl...............t...............p+GLpht...ppKhs....hLspPp.shh.s..ph..uDlhpspshpsu..........s.splhh..c...s.hptch.cplt-s.............spsslsssPsa-phl......uc.stsplsshhs..hhsattsthhhhEh...uhs.sphcP+ph.P..................................	0	13	22	31
+12344	PF12510	Smoothelin		Smoothelin cytoskeleton protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.	21.70	21.70	21.90	21.90	20.40	18.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.58	0.72	-4.11	16	284	2009-09-22 15:02:46	2009-09-22 16:02:46	3	6	61	0	105	292	0	50.10	44	9.26	CHANGED	sptps.ppspsssp.hst-l-pIhDEplLc.pLLEssosaEERRhIRAtlRcl+ppc	...............p.....tt.ptt.s..upcl.sh.D.thLc..ph..L-pss-aEER+hIRAAlR-LRppc..	0	16	23	53
+12345	PF12511	DUF3716		Protein of unknown function (DUF3716) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length.	21.30	21.30	22.50	21.70	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.84	0.72	-4.36	50	170	2009-09-22 15:04:55	2009-09-22 16:04:55	3	7	56	0	133	167	0	57.30	30	11.75	CHANGED	Ahhl..QspGppt..sps.CspCp.p...sp.....GP.F..psCV........hhsst.........htsuCuNChasspupp.CShpp	.........AhhhpspGp.s...tpsCppCp..p....sp............GP..F.spCl.........lhsup...........htsuCuNChas....spust.Cohh.t........	0	18	64	110
+12346	PF12512	DUF3717		Protein of unknown function (DUF3717) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 117 amino acids in length. There is a conserved AIN sequence motif. There are two completely conserved residues (L and Y) that may be functionally important.	25.00	25.00	33.00	32.80	21.80	19.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.28	0.72	-4.33	29	154	2009-09-22 15:21:54	2009-09-22 16:21:54	3	2	113	0	59	128	14	70.90	44	76.54	CHANGED	M.ss..lpIs-lEuAINaWRs+pPS....s-thsLssEupALA-lYAlMIhp+pspls.ssLsststsAhtuahpsp	........ssIoIp-lEAAINaWRuRuPu...ssD-ltLCsEAsALAcsYALMIsp+psslsh-uLsscARsAapuah...p..	0	3	17	40
+12347	PF12513	SUV3_C		Mitochondrial degradasome RNA helicase subunit C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.	21.60	21.60	21.80	24.70	18.90	21.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.32	0.72	-4.52	83	441	2009-09-22 15:25:28	2009-09-22 16:25:28	3	7	383	2	272	424	7	48.20	30	6.89	CHANGED	LppLEshachlslYhWLShRa.sshFs-tphspch+ptlpphIpptLpph	...LhcLEshachlsLYlWLShRF..sh..FsD.tphspch+ptlsphIpptLpp.h........	0	83	158	225
+12348	PF12514	DUF3718		Protein of unknown function (DUF3718)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important. 	22.50	22.50	22.70	31.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.95	0.72	-3.92	41	115	2009-09-22 15:28:03	2009-09-22 16:28:03	3	1	56	0	58	113	27	68.90	32	56.60	CHANGED	lCcsstosshhpL++phK..........cp+l..............ph+plastlsCNGpSlhpFAhsps..Ascsuphl..........htphshp-lussp	..lCchltusc+scLR+plK..........-pRl..............+h+plasulsCNGpSLlcaAhtss..Ascsupal..........spplshp-Lu...........................	0	7	19	40
+12349	PF12515	CaATP_NAI		Ca2+-ATPase N terminal autoinhibitory domain	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00689, Pfam:PF00122, Pfam:PF00702, Pfam:PF00690. There is a conserved RRFR sequence motif. There are two completely conserved residues (F and W) that may be functionally important. This family is the N terminal autoinhibitory domain of an endosomal Ca2+-ATPase.	21.70	21.70	28.50	27.80	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.31	0.72	-4.45	28	163	2009-09-22 15:29:38	2009-09-22 16:29:38	3	12	30	0	103	162	0	46.50	48	4.79	CHANGED	hhpcsF.-ltu.........KN....uStEuLpRWRpuss..lVhNspRRFRhssDLsKcs-s	....hp-sF.-l.u..KN.............uStEsLcRWRpAs...lVhNspRRFRaTsDLcKcpEh......	0	13	62	85
+12350	PF12516	DUF3719		Protein of unknown function (DUF3719)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important.	20.60	20.60	20.70	20.60	19.30	17.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.21	0.72	-4.41	14	139	2009-09-22 15:30:52	2009-09-22 16:30:52	3	2	57	0	72	128	0	64.50	40	12.14	CHANGED	hLaEG+sss..t..spsLppECppWss...+hPHLRlhGsQhhtPpccGapah.....susshp.pshhutssssss	............hLaEtKlus..p..TpuLppECppWss...paPHLR..lLG+QllhPtsEGapha..ussssSssp.cs..s.ttp...s......................	0	16	24	39
+12351	PF12517	DUF3720		Protein of unknown function (DUF3720) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. There are two completely conserved A residues that may be functionally important.	25.00	25.00	25.00	31.40	22.80	24.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.39	0.72	-3.30	38	82	2009-09-22 15:31:52	2009-09-22 16:31:52	3	1	2	0	19	82	0	93.20	33	25.57	CHANGED	KAVEAuEss..ELuussss.pc..p-sossstl.ssTpusuAPGsGG..tGVAGtsss......hP.ssPGGSsTtspptp..pslsspGscpss.cpspp-upsops..Q	.....KAVEAu-uu....pLuussss.ps..pcp.sstpl.ssTpusuAsGs..GG..suVAGt...ssss.....hP.ssPGsSsTttpp.tc..pslsspsscpsstcpsppssptsts..............	0	0	0	19
+12352	PF12518	DUF3721		Protein of unknown function	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. There is a conserved WMPC sequence motif. There are two completely conserved residues (A and C) that may be functionally important.	21.30	21.30	22.80	27.80	18.50	20.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.68	0.72	-4.35	41	73	2009-09-22 15:33:12	2009-09-22 16:33:12	3	4	30	0	26	80	320	33.70	46	32.13	CHANGED	asTctEAEppApc.hGCpGuHpM..Gs.pWMPCss...atp	.....asT+tEAEppAtc.hGCpGsHpM...Gs.pWMPCspHt......	0	2	10	20
+12353	PF12519	DUF3722		Protein of unknown function (DUF3722) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 415 and 473 amino acids in length.	25.50	25.50	34.20	35.60	23.20	25.40	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.77	0.70	-5.17	31	140	2009-09-22 15:34:49	2009-09-22 16:34:49	3	2	135	0	105	160	0	252.20	37	58.90	CHANGED	l+lplSshuTPphtooasLushsh..lsGSloYLaoossLpp..stsSpplsLpchlpsYRhlp..sshs.ppp..p..htsh.t.......................................oLLYGRhal.PsopLEAhhl+RlSPssQlhlpslSs.t..........................................................................sssuslhshlQ+DoG+aspEalaSTs-uLhGaRsLaNFGssssptt.....................s.hssp.....................plSsGuEhaauslspSsGhSTulRasThsssTsp................................PhTlTLohNPlhGplSoT.Yol+sSsshshsSRaDFN	........................................l+lplSshuTPphsoSa....sLushsh......lsGSlSYLaSohsLpp......stpSsplsLpchlpuYR.lp..ssht.t...tt...t...t......ts...s.tt........................................................toLLYGRhal.PsopL-Ahhl+RloPshQl.ltslSs.t..........................................................................tstuslhs.lQpDs..G+aspEhlaSTssuLhGaRsLaNFGssspp.ss.....................................p.p..............hs.....hlSsGuEhYYuslspSsGhSTGlRFsTlPsssup...................................................PhThTLolNPLhGplSoT.YolpsusshuhsoRa-FN.........................	0	27	56	88
+12354	PF12520	DUF3723		Protein of unknown function (DUF3723) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.	21.30	21.30	21.60	21.30	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.35	0.70	-6.01	20	202	2009-09-22 15:35:55	2009-09-22 16:35:55	3	6	44	0	161	209	1	265.00	18	50.16	CHANGED	C+RL-spN+lsAllScpsLstALppuslotssLh..sspp.PpLpFstG.plpCLHG+HRlpAup-h....Lssu.D+WWsVDLYhD.................slup-L+suLhEEYuNp+psoDGEIYR+IRpYp..........p-sNtthppRWhuRL.osppt+hhp...................h.thht.uhulspLhchhuLhss.......................EllpYLs.pltchWu.llss-.st.....ht+lDscTVctLEhhuPthSctDuptlpslltuGplFssFsp.sERpslhccLp...shcGlIPSLaTFFcDhcYLEsCAcsl++Lls.s..p.olppshpthas.tssss..pptllQooEsshpp...ppsusspph-luY+QlWLaAMRaasphspsst....pcshhs+sspppuDppsla-hAsLAp+LGFpSspIcsLhspuscRp.hApthLhpARps-tYpYsssph-slVp+IV-shssA.h.ppht.sschhsspssph+s.....RCGhPptpupcpD+chLFlDclautpssssshl.TohhVRRslaFAFFG	.................................................................................................................................................................................................................................................................................................................................................................................h................hs..sl..lp.............h.....h.tt..hh........h..h...h.....h.......l.oh..h.tsh.hht.....ht.h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	12	47	136
+12355	PF12521	DUF3724		Protein of unknown function (DUF3724) 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF00073. There is a single completely conserved residue Y that may be functionally important.	22.00	22.00	22.50	22.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.66	0.73	-7.06	0.73	-3.91	5	178	2009-09-22 15:37:19	2009-09-22 16:37:19	3	11	6	0	0	111	0	22.90	88	6.99	CHANGED	RupGcVVcDYSRYosAosssst-	.RSQAYMVKNYPTYSQTITNTATD..	0	0	0	0
+12356	PF12522	UL73_N		Cytomegalovirus glycoprotein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF03554. This family is an envelope glycoprotein of human cytomegalovirus (HCMV).	20.30	20.30	22.80	22.80	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-6.99	0.72	-4.40	5	115	2009-09-22 15:38:45	2009-09-22 16:38:45	3	1	5	0	0	82	0	25.90	67	19.32	CHANGED	LGLLVLSVAAGSSGNNSSTSTSATTsS	.LGLLVLSVsAuS..NNoSTuoososSS.	0	0	0	0
+12357	PF12523	DUF3725		Protein of unknown function (DUF3725)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01577. There is a conserved FLE sequence motif.	20.80	20.80	21.10	112.00	20.60	17.50	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.48	0.72	-3.89	4	55	2009-09-22 15:39:49	2009-09-22 16:39:49	3	5	5	0	0	51	0	73.90	79	5.45	CHANGED	ahoEFclScGAKILQLV.IGsAElGRsFLEGs+hlRAsIFEIl+KTMVG+LGYDF-sELWhCHsCspTS-KYFK	YsSEFcISKGAKILQLV.IGNAEVGRTFLEGNRFlRANIFEIIRKTMVGRLGYDFESELWhCHNCscTSEKYFK	0	0	0	0
+12358	PF12524	GlyL_C		dsDNA virus glycoprotein L C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is typically between 55 and 80 amino acids in length. The family is found in association with Pfam:PF05259. This family is the C terminal of glycoprotein L from various types of double stranded DNA viruses (dsDNA).	20.10	20.10	28.70	26.80	18.60	17.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.08	0.72	-4.06	10	48	2009-09-22 15:41:28	2009-09-22 16:41:28	3	1	20	1	0	45	0	70.40	44	32.42	CHANGED	uuStsPVssGCVNh-hS+sRpChGpsshshFscsphhpP.susDD...............hs.uRtssc+s+ssRupss+	..........AuSpsPVtuGCVNh-YSRsRpChGppcLGhhNtspsppPshssDDEAu.Qs.s.ss.ss.hA.ScssP+RssAs+u+pp+..................................	0	0	0	0
+12359	PF12525	DUF3726		Protein of unknown function (DUF3726) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length. There is a single completely conserved residue E that may be functionally important.	22.10	22.10	22.10	22.40	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.42	0.72	-4.18	34	82	2009-09-22 15:42:57	2009-09-22 16:42:57	3	1	79	0	18	89	671	78.10	31	33.98	CHANGED	hhShNEltuhspKAhcGhGhshG.A--sAphsthLphhG....LsGsptLsssLphhsspssssl.s.h................hpsss.hhsstpshss	.....hShNEl.AhspKAhhGhthshGpA-thAphls.LphhG....LsGlpphspshphhshpsspsl.s...................tsss.h.hsh+t.S.................................	0	5	9	15
+12360	PF12526	DUF3729		Protein of unknown function (DUF3729) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01661, Pfam:PF05417, Pfam:PF01660, Pfam:PF00978. There is a single completely conserved residue L that may be functionally important.	25.00	25.00	43.00	25.30	22.40	24.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.55	0.71	-2.72	39	273	2009-09-22 15:48:27	2009-09-22 16:48:27	3	10	14	0	0	277	0	99.30	46	9.34	CHANGED	HhW..........ESANPFCGESTLYTRTWSsSGFSSsFSP.Essssssssssshsps....sPP.ssslhs.PPssEpssssss.ssssspP..ss.............ssuss..sPss...PsppsspPs.......u.pRRLLaTYP	...................HhWESANPFCGEuTLYTRTWSsSGFSSsFSPPEsuhsssssssthsps....sPs.ssshhs.PPssEpstsssssssssscP..ss.............ssuss......sP.s....PspcsssPs.......uppRRLLaTYP.......................	0	0	0	0
+12361	PF12527	DUF3727		Protein of unknown function (DUF3727) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length.	21.50	21.50	21.90	21.90	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.39	0.72	-3.91	34	108	2009-09-22 15:50:23	2009-09-22 16:50:23	3	2	94	0	49	109	114	97.90	35	44.90	CHANGED	pcLpLh+oAh.TLTVsGELs.h----l.ph-.-c-.....tc.-sEp..hphLso.Fhh--pEYulYsPLDPhhhlA+..hss.spspLlss-Ehc....clpPll...EppLh-ch	...........................cLpLhcoAh.sLTVpGELs.hp---l.phc.-s-t....sc.-sEplElLss.Fh.h-spcYulYTPLDPlLhlA+..hsp.sps.Ll.ss-Ehp....plpsll...EppLhpt.h.......................................	0	13	33	44
+12362	PF12528	DUF3728		Prepilin peptidase dependent protein C (DUF3728)	Gavin OL	lg7	Prosite	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 106 and 121 amino acids in length. The family is found in association with Pfam:PF07963. There are two completely conserved C residues that may be functionally important. This family is frequently annotated as prepilin peptidase dependent protein C.	22.50	22.50	31.20	30.60	20.20	16.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.97	0.72	-3.59	24	542	2009-09-22 15:52:35	2009-09-22 16:52:35	3	2	530	0	39	167	1	74.80	63	69.32	CHANGED	YpQsLhpuFsphaQ.RQsW+hhaQph-hhs.s...............sssWQhpphpsp......pusCsploVplhoPtsppuploRhaCssp	..aQRsLMsShASRsQYpQLWRauWQQTQLpuhS....................PPssWQVNRMQTS......QAGCVSISVTLVSPuGRpGEMTRLHCPNR..	0	2	8	23
+12363	PF12529	Xylo_C		Xylosyltransferase C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 169 and 183 amino acids in length. The family is found in association with Pfam:PF02485. There is a single completely conserved residue G that may be functionally important. Xylosyltransferases are enzymes involved in the biosynthesis of the glycosaminoglycan linker region in proteoglycans.	25.00	25.00	25.60	25.10	23.50	16.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.04	0.71	-4.90	24	190	2009-09-22 15:54:46	2009-09-22 16:54:46	3	6	82	0	97	161	0	172.10	45	21.16	CHANGED	-paLaGpYssssPsL+uYWpNlYcp..D.shsuhsDstlohhpShhRluhpp..t......tptts+hcsht...shplphYhpcDpFpG....aLV+acu............t..sstpt.pLEsaltPpsshplspts..ptupRLpsl..-..VGT-aD.KEplhRNaGtllGPpsEslhht+Wutut...........shssTllWIDPhthlAss	...............................................D.aLY.GsYPsGTP.uL+uYWENlY-p.sD.GhsuLSDlhLThYpuFuRLuL++stssht...sptpC..RatPhG..hPsSVHLYFhsD+FQ.G....aLl+pps.............ps..AsuphEoLEsWlhPppshKlssss...sphsRLQph...E..VGT-WDsKERlFRNFGGLLGPhDEPVuhQ+Wu+Gs...........NlTsTVlWIDPssVlAs.......................	0	20	26	57
+12364	PF12530	DUF3730		Protein of unknown function (DUF3730) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 220 and 262 amino acids in length.	25.00	25.00	29.80	25.10	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.49	0.70	-4.44	25	180	2009-09-22 15:55:45	2009-09-22 16:55:45	3	7	96	0	122	185	0	222.30	20	24.00	CHANGED	hlhhLhht.......htcsssschhhphLpsLssLuspp............hth.hllpslssLspssstph..................................hthcLlsplatpss+ta.....shLpthLt.......tsspssppphchtluhssoh+slCptpPp............+us-llthlstsL.........pppssl.....................................spuhul-ulpslC............pscll-hhssWplltpcl......s.p.cP.lhp...........................phh.ll..hthsstphsp........hpppslpllWchhstpc.......spsphhshpuL	...................h....hhht........tc.ppsph.hthLphLsphsspc.......................................sshshhlpslthLsspsphph........................................hh.pLlstlhptpspha.....shLpth...hth...p..p..t.s.p.....p.p...........ph....cphhuht.ssh+slCptpsp............pus-hlttlothl.........ppssts.....................................................................spuhslphlpsLh............pupllshtstW.psLtt.pl.......t.t.ps.h..............................phh...Lhsththsp.tphpt...............hp.pllphhWphstp.p.......h.s..hh.....................................................................................................................	0	30	47	81
+12365	PF12531	DUF3731		DNA-K related protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 250 amino acids in length. There are two conserved sequence motifs: RPG and WRR. The proteins in this family are frequently annotated as DNA-K related proteins however there is little accompanying literature to confirm this.	25.00	25.00	145.50	144.60	24.00	22.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.65	0.70	-4.85	38	220	2009-09-22 15:58:22	2009-09-22 16:58:22	3	2	219	0	66	205	15	247.40	51	26.58	CHANGED	SAcHERhWLNLAGaCLRPGFGsslDsWRlpQlWslaspGlQasp-sQsWs-WWshWRRlAGGLspspQtplhc....slA.hLpss.stpptph...ts...pttuhp-MlRLuAuLERlssppKhcLupalLpR...Lp+ss...............tstptW.WALGRlGARpPhYGSsHpVlPscpsppWlstL...LphD.W+c.t......suFAssplARhTGDRsRDLs-shRppVlc+LcsspAspsWlphVpEl.spL-ps-ppRlFGEuLPsGLpLl	............StsHE+sWLpLAGaCLRPGFGcshDuWRIEQlWsLYpQGIQas.ssQsWo-WWlhWRRlAGGLsp-QQpplLs....-IApaLpPuuh+...sstts....pcu...pctGY-sMVRLuASLE+LtVEcKs.LupWhLs+...Lp+sp................ppspW.WALGRLuARsPhYGStHsllPtEpsppWLspL...LcpD......Wpcps.....hsAFAsV.hsRhTGDRsRDls--hRppVlc+L+po+ss-uWlshVpEV..l-L-cu-opRsFGEoLPsGLpL.........	0	20	31	53
+12366	PF12532	DUF3732		Protein of unknown function (DUF3732)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is typically between 180 and 198 amino acids in length. There is a conserved DQP sequence motif.	25.00	25.00	35.00	34.80	24.80	22.40	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.24	0.71	-4.78	50	147	2009-09-22 15:59:45	2009-09-22 16:59:45	3	5	141	0	42	122	9	187.10	30	30.98	CHANGED	pplppLcppls.tpshpp+h..psshsplsph.hschupplchEps...stslchshcphsl......hhsspscphhL......pchGSGuNWluhHlshaLALHcaFhpp.....ppslP..shLhlDQPSQVYFPs........tpshstppl.........................................pDpDhtuVpchFphLsphspchpt......phQlIVh-HAs.pt....p.htsshh.ppWR..pscuLI	.................t.plptLctpls....pc...hpc+h...ctthsplsph.hschhtpLchEps...ssslphshc.phsl......hhspsscphhL......hclGSGuNWLuhHlulhLALHpaFspht....sssVP..saLlhDQPSQVYFPs...tttts.cp.pclt........................................pD-DlhsVcclFphlsphhpctpp......shQIIVh-HAspp.htth.....pshh.pcWR..psptLI..............	0	16	23	32
+12367	PF12533	Neuro_bHLH		Neuronal helix-loop-helix transcription factor 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to Pfam:PF00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.	25.00	25.00	26.20	25.20	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.83	0.71	-3.30	21	229	2009-09-22 16:01:00	2009-09-22 17:01:00	3	3	65	0	114	175	0	119.40	49	36.79	CHANGED	G+pPDhluFVQsLCKGLSQPTTNLVAGCLQLNsRshLs-p.tsctusp...ssusasspsasY......psP....tLsoPs....tsoh.....susH.h+.....stsYtush-shat.....ssss-tsoPpa-G..sLoPP.lslsGsFS	.....GKpPDLloFVQsLCKGLSQPTTNLVAGCL......QLNsR.sFLh-Q.st-tss+..........ssusassHs.asY.......pSP....tLsoPP........aGsh.....ssoHsh+.....sasYs.u.u.hEshat.........usss-ssSPpa-G..PLSPP..lslNGNFS................................................	0	12	22	56
+12368	PF12534	DUF3733		Leucine-rich repeat containing protein 8 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00560. There are two completely conserved residues (W and Y) that may be functionally important. Many of the proteins in this family are annotated as leucine-rich repeat containing protein 8 however there is little accompanying literature to back this up.	25.00	25.00	50.80	35.60	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.23	0.72	-4.68	22	480	2009-09-22 16:01:50	2009-09-22 17:01:50	3	39	44	0	283	366	0	62.00	36	15.95	CHANGED	Mhsls-hppas.tpQssY+lLKPWWDVFhsYLsllMlhlulhuushth.t.phh.ChPs.pspthppp	...........hssh-hpQas..sQssY+lhhPWashahsYLsllhhhIhlhuush.h.......phPs.psuphpp........	0	16	46	119
+12369	PF12535	Nudix_N		Hydrolase of X-linked nucleoside diphosphate N terminal 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 847 and 5344 amino acids in length. These enzymes hydrolyse the molecular motif of a nucleoside diphosphate linked to some other moiety, X.	20.60	20.60	20.60	28.30	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.86	0.72	-4.51	85	803	2009-09-23 12:17:57	2009-09-23 13:17:57	3	4	787	4	107	492	28	56.60	37	27.66	CHANGED	ppphLcaAtclQulAQuGLsYu+DsaDhERY-clRcIus-hhuptoslshcplcsLFs	....t..calcahpcl.ulupsGLsYo....K.DsFDpERYccLRplss-Mluphoch.sh-pltplh...............	1	39	72	90
+12370	PF12536	DUF3734		Patatin phospholipase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF01734. There are two completely conserved residues (F and G) that may be functionally important. The proteins in this family are frequently annotated as patatin family phospholipases however there is little accompanying literature to confirm this.	22.00	22.00	22.00	24.10	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.29	0.72	-3.93	64	300	2009-09-23 13:23:11	2009-09-23 14:23:11	3	7	189	0	108	296	13	105.30	29	24.71	CHANGED	IpYSSRTRhpo-thcphpphRcslpcLhp+lPtph+s.-Pthptltphus..ssthsllHLIYpppshEsps.KDa-FSptohc-+WpuGhcDscpsLp..c.pWhptsssspG	...........................IpYSSRTRhsT-hhpphpchRpslccllp+lPt..p.+p..c.........s.....h..pthtphus..ssphsllHLIY..ppcshEspt..KDY-Fotsohp-+WpuGhcDhcpsLs..p.phhthsp..................	0	18	49	76
+12371	PF12537	DUF3735		Protein of unknown function (DUF3735)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved LSG sequence motif. There is a single completely conserved residue G that may be functionally important.	22.10	22.10	23.10	27.40	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.06	0.72	-3.93	46	266	2009-09-23 13:55:43	2009-09-23 14:55:43	3	8	220	0	188	278	2	71.80	38	14.39	CHANGED	tshhhhcphls+lullGlTlhAlLSGauuVssPYphhs.........hhhc.ss............ct..clpshpppltpotshltpK+p..clp	.........shhshcphloRlGVIGVTlMAlLSGFGAVssPYshhs.........hFhRsls............-s..DItshE+pLhpTh-hlhsKK++l.........................................	0	64	103	153
+12372	PF12538	FtsK_SpoIIIE_N		DNA transporter 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 107 and 121 amino acids in length. The family is found in association with Pfam:PF01580. The FtsK/SpoIIIE family of DNA transporters are responsible for translocating missegregated chromosomes after the completion of cell division.	21.50	21.50	21.70	22.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.19	0.71	-3.97	18	321	2009-09-23 14:46:06	2009-09-23 15:46:06	3	4	319	1	22	218	0	107.70	40	7.71	CHANGED	hLhlhYppplp+hcLss...pcsloIGsshcsslTlssL...cpsIpLchcps.......hhphptpsLthscshplshttp.hhhhahspsppsplYsluscpplsluspct..sDIslpssps	........hLIIpYscpL+hhsLcs...sKohTIuc--+ADITLpSL...uEsIcLcpNN........pGshQsscsslNK.slshcs..sh-shpL.LYopsshsuhhasuhp-ohTIGsNsY..DDhsIpuh.hs.....	0	5	11	16
+12373	PF12539	Csm1		Chromosome segregation protein Csm1/Pcs1	Mistry J, Wood V	jm14	Manual	Family	Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis [1].  Csm1 also plays a mitotic role in DNA replication [1].  This family also contains the Schizosaccharomyces pombe homologue to Csm1, Pcs1.  Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together [3].  The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment [3].	22.60	22.60	22.70	23.10	22.40	18.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.09	0.72	-3.50	29	121	2009-09-23 14:54:00	2009-09-23 15:54:00	3	4	118	16	91	114	0	91.60	39	22.85	CHANGED	hplpcDLap...pLTGlplpssccc..-sshhFDshQoupN..G.......slca+Lsls+sts............tp...........sEhpYhPhL.......cppp-c...............pLhchLP-YLp-sloFPhpp	....................u.plpcDLYpcLTGLhl+ssccc..-sshlaDClQTGpN..G......................sl+aKLulspsps............ps................sEhpYhPhLcpsc-c......................pLhclLP-YLs-sloFPhp.................	0	17	45	77
+12374	PF12540	DUF3736		Protein of unknown function (DUF3736)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 135 and 160 amino acids in length.	22.60	22.60	27.30	23.30	21.40	19.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.72	0.71	-3.95	10	166	2009-09-23 15:32:06	2009-09-23 16:32:06	3	3	65	0	89	153	0	140.60	30	24.34	CHANGED	psccshuSclshEup.........+lppPtpcauusspss+cSs...s.lhVssss+uVssoPPlsp.sss+plphlhcsstps.ppscph.cup.hhRcRhl..........scss.sp+.......psttss.........sPu...hspshshthoPs..shsQ-schQs.p.....lsLs+	...........................................t..p.hsSclshEpp.........+hppstEc..u.h.s.ccss...s..tV.sth+sVs-pPPlsp.sso...cplphlhh.t..p.ppt-ph.pspptt.RcRhl............................csP.stp...........htst.s.................sPu.....t.sh..shthoPs..phspssphp........hsL...........................................................................................................................................	0	12	22	50
+12375	PF12541	DUF3737		Protein of unknown function (DUF3737) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 281 and 297 amino acids in length.	22.10	22.10	22.60	32.90	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.00	0.70	-5.42	36	223	2012-10-02 14:50:22	2009-09-23 16:35:19	3	2	209	0	39	195	4	258.30	45	96.08	CHANGED	MppIcpphasGERALFss+shplpsshFs...DGESsLKEo+NIplpsshFchKYPhWascslplcssphp-huRAulWYopslphpsoplpAPKtFRcspslpLcssshssAtEThWsCcslplcssps.pGDYFhMsSpNlhl-slpLsGNYuFphs+NlEl+NuclhSKDAFWNsENVTVhDShIsGEYLGWpS+NlThlNCpIpusQsLCYh-sLslcNCchl.sTcLAFEY.SsV-AsIsusIsSVKNPhSGpIpAcpIGclIhDcsplss.spspIhsp	....Mp.IcpphasGERsLFstcDhplpsssFs...cGESsLKEspNIphpsshFchKYPhWascshplcsshFpphuRuul.WYopslphpsohlpAPKhFRcspslpL-NVphssApEThWpCcslplcNlph.pG-YhhMpSpNIhlDslp.sGpYsFphs+NVEl+NuplhoKDAFWpsENVTlYDS.lsGEYLuWpS+NlphlNCpIpupQsLCYhcsLshcNCphh.ssDLAFEY.SslpAsIpusIpSlKNPhSGpIpAcplGplIhDcsthss.spspl..t.............	0	12	23	31
+12376	PF12542	CWC25		Pre-mRNA splicing factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.	26.10	26.10	27.20	27.20	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.59	0.72	-3.54	62	293	2009-09-23 15:39:42	2009-09-23 16:39:42	3	5	251	0	220	284	0	95.10	32	23.98	CHANGED	c..cctp+l-........WMYpss.................ttttpppE-YLLGK......pclD.phlppppttptpthsptpt..............................sstp-thsKl.p-DPLhtI..KppEppthpthhpss	..........................p+pc+L-........WMYpuP...................ssttppE-Y..LLG+.....plDph.lt....ppp...pp..ctptsuspssh...h..ss....................................sottDhtsKl..+EDPLhhI..++pEppthcthhpsP.................	0	73	122	182
+12377	PF12543	DUF3738		Protein of unknown function (DUF3738)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 457 amino acids in length.	21.90	21.90	23.40	24.90	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.18	0.71	-4.73	49	107	2009-09-23 15:51:44	2009-09-23 16:51:44	3	9	14	0	98	138	12	196.00	27	60.42	CHANGED	LpsllthAYslp....shQ.lsGPsWl........ssc+..aDlsA........Kh.....Psuss........pc......ph.tMLQsLLs-RFpLshH+Eo+chslYsLsluKs....GsKl+tsssssssstss.............................................tttphpspphshstLAc....hL.....u..phhs....pPV.lDpTGLsGpYDhsLpas.pt........................................................sssssslhs.AlpcQL...GLKL.cscKtPl-slVlD+sc	.............................................ttllthAYslp......s.ph....h.suPsWh........ssp+..aDl...A...........+s...........ss.sss..............pp................phptMLQsLLs-RF.pLphHpEs+chssYsLsluKs....GsKLctsps.sssss.s.s..............................................tstphpspshshsplup............hL.........s.....thls...cPV.lDpTGLsGpYDhsLpassps........................................................sssssslhs.AlpcQL...GLKL.cspKssl.-slVlD+h..................................	1	74	98	98
+12378	PF12544	LAM_C		Lysine-2,3-aminomutase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is typically between 111 and 127 amino acids in length. The family is found in association with Pfam:PF04055. LAM catalyses the interconversion of L-alpha-lysine and L-beta-lysine, which proceeds by migration of the amino group from C2 to C3 concomitant with cross-migration of the 3-pro-R hydrogen of L-alpha-lysine to the 2-pro-R position of L-beta-lysine.	26.70	26.70	26.70	26.90	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.52	0.71	-4.09	14	526	2009-09-23 16:00:04	2009-09-23 17:00:04	3	8	452	4	212	447	50	90.00	46	21.48	CHANGED	IEuLRGHTSGYAVPTFVVDAPGGGGKIslpPNYlISQSs-KVVLRNFEGVIToYPEP-sYhs.....tps-shFtph....tpcpp.hGluuLhs-..c.phuLsPcsLpRh-RRcth.tp.ttpohKcpRc++-	......hEuLRGHTSGhAVPTaVlDAPGGGGKlPlh.P.s.Y.l...lS..p.....u...ss+.l...lLRNaEG.hlssYs-..P..t................................................................................................................................	0	97	161	189
+12379	PF12545	DUF3739		Filamentous haemagglutinin family outer membrane protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF05860.	20.50	20.50	21.20	48.10	18.30	19.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.48	0.71	-3.95	24	96	2009-09-24 09:08:12	2009-09-24 10:08:12	3	4	63	0	46	104	5	111.90	55	3.05	CHANGED	GGDIhhWSupGDIsAG+GuKTslsssPsph..l.......hDsp.Gssp...ls.sussoGuGIusLpshss.......s.tsGsVsLlAPpGslDAG-AGIRsuGNlsluAhpllNAsNIp.VsGsssGlPss	.GGDIhsWSupGDINAGRGSKTollhsPP.+t..l.......YDsh..GNVo....LsspsPuoGAGIATLsslP-........l..ssGDlDLIAPhGTIDAGEAGIRVSGNlNlAALpVlNAuNIQ..l.pGpooGlPs.......	1	3	17	26
+12380	PF12546	Cryptochrome_C		Blue/Ultraviolet sensing protein C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 113 and 125 amino acids in length. The family is found in association with Pfam:PF03441, Pfam:PF00875. Cryptochromes are blue/ultraviolet-A light sensing photoreceptors involved in regulating various growth and developmental responses in plants.	22.80	22.80	23.20	23.10	19.80	22.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.09	0.71	-3.42	20	114	2009-09-24 09:12:39	2009-09-24 10:12:39	3	3	39	0	22	110	0	116.80	39	20.11	CHANGED	sPIuFPp-lp.MEhc+p..PlR.ss.........sshs..RRhcDQMVPoM.T......SSlhRs.p-pEhSu-h..pssu..tD.oRAEVPsph..h...........tspsppcphhspssspss.............hppppsh.p..pphhttt.htsSTuESSSShp	....sPIsFPp-lp.ME.scp..PsRsss.........hsss..RRhcDQMVPSh.T.......SSllR...s...p-pEhSsDh..pN.s...s-SRAEVPpsh..h...........psptppc-slspshspss..............ppppsh..t.phppphtttshtsSTuESSSShp....	0	3	10	16
+12381	PF12547	ATXN-1_C		Capicua transcriptional repressor modulator 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 49 and 781 amino acids in length. There is a conserved IQT sequence motif. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells. The polyglutamine expanded mutant type of ATXN-1 does not bind Capicua with as high affinity as wild-type ATXN-1. It is associated with spinocerebellar ataxia type 1 (SCA1).	25.00	25.00	25.80	27.40	22.90	23.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.50	0.72	-4.00	5	77	2009-09-24 09:15:23	2009-09-24 10:15:23	3	2	60	0	27	69	0	39.00	78	8.02	CHANGED	GLpLGKPVSRSsShosppS.th.....p..p.tu.VsolSPHTVIQTThsuoEuLP	..GLHLGKPGHRSYA...........................LSPHTVIQTTHSASEPLP.....	0	1	4	9
+12382	PF12548	DUF3740		Sulfatase protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with Pfam:PF00884.	25.00	25.00	30.50	30.50	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-3.92	21	188	2009-09-24 09:16:27	2009-09-24 10:16:27	3	4	75	0	95	159	1	142.50	43	16.51	CHANGED	hptpas+pRppRul.hch....-splhclshE....cc.hph.pshslhccH..............pccsc+-spp.ssss........sssssshhss.pplpsTh............................................RCalhsN.DpVpCssslYcstcuWKcp+spIDt.IcsLpsKIpsL+El+tpLKcp+Pppssss+t	....................................................................................................+spas+sRptR.S.lu..lEh....-GplYclsL-...ptt.....psRslsKRH..............tcpscp.ch...t..s...sGss.............hhsss.sthussssl+VTH...............................................................................+CaIL.N.DTVpC-p-LYpShpAWKDHKhaID+EIEsLQsKIKNLREVRGHLK++RPEECsCsK.........	0	12	19	56
+12383	PF12549	TOH_N		Tyrosine hydroxylase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. Tyrosine hydroxylase converts L-tyrosine to L-DOPA in the catecholamine synthesis pathway.	21.10	21.10	23.20	21.20	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.35	0.73	-6.60	0.73	-4.23	7	141	2009-09-24 09:17:42	2009-09-24 10:17:42	3	8	42	0	40	141	0	23.40	47	13.09	CHANGED	PTPshuoPphpGhRpAVSEhDsKQA	................shsSPphhGhRpul.E.stKpt	0	3	5	14
+12384	PF12550	GCR1_C		Transcriptional activator of glycolytic enzymes	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.	21.70	21.70	23.30	27.10	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.81	0.72	-4.11	69	275	2009-09-24 09:19:23	2009-09-24 10:19:23	3	11	71	0	192	269	0	79.80	27	13.55	CHANGED	paphs+shpoVt-lacEahpG..htGpPulpph......-pcaG.spWR....ssppp..phap+RKhlhchIpp............shp.cshstppslchlEphR	.......achs+s.poVh-lacEahtG.......ltGpP..olcpl......-cpYG.spWRt...sspcp......+has+.....R+hlhchIpp.................s.p.pshshppslphlEphR.......................................................	0	38	111	186
+12385	PF12551	PHBC_N		Poly-beta-hydroxybutyrate polymerase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF07167, Pfam:PF00561. There is a single completely conserved residue W that may be functionally important. PHBC is the third enzyme of the poly-beta-hydroxybutyrate biosynthetic pathway.	25.00	25.00	31.30	31.60	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.24	0.72	-4.43	58	186	2009-09-24 09:22:42	2009-09-24 10:22:42	3	3	155	0	73	185	19	45.40	41	7.67	CHANGED	ssssshptlD+th+Asl.A+hTuGlSPsulthAahDWuhHLAsSPGK	......s...s.hphlD+thcAsl.A+hTuGLSPAuLshAahDWhhHLAsuPGK...........	0	14	40	58
+12386	PF12552	DUF3741		Protein of unknown function (DUF3741)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length.	21.80	21.80	22.30	35.20	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.17	0.72	-4.24	30	140	2009-09-24 09:27:59	2009-09-24 10:27:59	3	5	19	0	93	127	0	45.00	40	5.10	CHANGED	lppKhh-u..K+Lus...DcphppSKEFh-AL-lLsSNK-LFlKhLQ-Pso	................lppKhh-u..KcLuo...cpphppSKEFt-AL-lLsSN+-LFLKhLQ-Pss...	1	11	52	76
+12387	PF12553	DUF3742		Protein of unknown function (DUF3742)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. There is a single completely conserved residue Y that may be functionally important.	20.90	20.90	21.10	21.00	20.10	19.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.06	0.72	-3.51	20	78	2009-09-24 09:30:26	2009-09-24 10:30:26	3	1	60	0	28	76	3	51.80	29	43.65	CHANGED	LALL.LsFsllAAWhspssss....................DpsEtt...sEaRpG.uGaGLYcss.hRlD	.........................................hALl.lshlslAuWhspsss..............................c.s-...........phRpG.sGaGhYsss.hRlp.........................	0	5	19	26
+12388	PF12554	MOZART1	DUF3743;	Mitotic-spindle organizing gamma-tubulin ring associated	Gavin OL	lg7	Prosite	Family	The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes [1].	19.90	19.30	21.30	24.10	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.04	0.72	-4.50	48	221	2009-09-24 09:35:15	2009-09-24 10:35:15	3	7	188	0	167	215	0	47.20	48	44.27	CHANGED	upcsl-llaclSsLLNT.GLD+csLslslpLlEsG.VsPcALApllpcl+	......c-shDlLaEISplL....NT.uLD+cTLSlClpLhEpG.lNPE.ALA.....sVl+ELR.....	0	49	82	127
+12389	PF12555	TPPK_C		Thiamine pyrophosphokinase C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. The proteins in this family catalyses the pyrophosphorylation of thiamine in yeast and synthesizes thiamine pyrophosphate (TPP), a thiamine coenzyme.	22.70	22.70	24.30	26.70	22.30	22.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.42	0.72	-4.24	50	284	2009-09-24 09:39:24	2009-09-24 10:39:24	3	3	282	0	98	221	0	53.40	32	13.78	CHANGED	+uVupLY+sRlSst.tlhhllLAuLlAlssslhlossu..pshhphlssphpshht	...KuVupLYRs+lSsu.ulhhLlLusLlAlhlslhlosss..tshlphlhspWsphh......	0	44	78	92
+12390	PF12556	CobS_N		Cobaltochelatase CobS subunit N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF07728.  There are two completely conserved residues (P and F) that may be functionally important. This family is the N terminal of the CobS subunit of cobaltochelatase. Cobaltochelatase belongs to the AAA+ superfamily of proteins. CobS and CobT form a chaperone like complex.	21.50	21.50	21.70	23.20	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.70	0.72	-4.52	79	346	2009-09-24 09:46:14	2009-09-24 10:46:14	3	3	337	0	109	304	959	35.70	48	11.07	CHANGED	spshhstPDpplSVR-lFGIDoDhpVPAFoc.ts-+V	.......shsshPDppVSVR-VFGIDoDhpVPAFop.sss+V....	0	28	67	82
+12391	PF12557	Co_AT_N		Cob(I)alamin adenosyltransferase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF02572. Cob(I)alamin adenosyltransferase adenosylates Co(I) in an ATP-dependent manner in the conversion of aquacobalamin to its coenzyme form. This is the third step in this process, after two steps involved in the reduction of Co(III) to Co(I).	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.64	0.72	-6.66	0.72	-3.98	89	1083	2009-09-24 09:49:35	2009-09-24 10:49:35	3	3	996	1	172	551	72	22.10	48	11.01	CHANGED	tsstcspRHptRMp+hKpshDp+l	...........sERappRQQ+lK-pVDARl...	0	23	74	122
+12392	PF12558	DUF3744		ATP-binding cassette cobalt transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00005.  There is a conserved REP sequence motif. There is a single completely conserved residue P that may be functionally important. The proteins in this family are frequently annotated as ABC Cobalt transporters however there is little accompanying literature to confirm this.	22.50	22.50	22.70	24.00	22.40	18.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.28	0.72	-3.53	55	750	2009-09-24 09:52:23	2009-09-24 10:52:23	3	4	746	0	68	428	1	72.30	36	12.82	CHANGED	poslLpchGlREPLYloALKtuGhslsphpclsslssLshsp.hpttlppWhp.ptshhppppppc.............sLLclcsLoa	......oslLppsGIREPLYlTuL+thGlDlsptcpLusL.cslshsc.h...hppa....psp....scpp.ctp.............sLLcLcpVoa..............................	0	19	34	49
+12393	PF12559	Inhibitor_I10		Serine endopeptidase inhibitors	Coggill P	pcc	MEROPS_I10	Family	This family includes both microviridins and marinostatins. It seems likely that in both cases it is the C-terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. it is the ester linkages within the key, 12-residue. region that circularise the molecule giving it its inhibitory conformation [1, 2, 3].	20.50	20.50	26.20	22.20	18.00	18.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.17	0.72	-3.69	18	45	2009-09-25 12:15:30	2009-09-25 13:15:30	3	2	25	1	16	49	1	49.40	44	91.94	CHANGED	Msps.........p..p.cAl.PFFARFL-pQ..................................t.tstsstpsp.s.h.ThKYPSDhE-s	..................psppsKAl.PFFARFLpspp...............................t.ps.psssscssh.sThKYPSDWE-..	1	2	7	16
+12394	PF12560	DUF3745		Protein of unknown function (DUF3745)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00097, Pfam:PF10426.	21.20	21.20	21.20	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-7.87	0.72	-4.29	99	1647	2009-09-25 12:31:12	2009-09-25 13:31:12	3	7	890	0	1	1687	0	38.20	45	8.84	CHANGED	ANs-KGKsAASLDKVs....DshsLhsQc.PFcpcppLNsuhQo	...ApppptcsAASLDKVsEpp.-ssslhsp..PFcoDp-LNpuhQT......	0	0	0	1
+12395	PF12561	TagA		ToxR activated gene A lipoprotein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF10462. There is a conserved GAG sequence motif. This family is a bacterial lipoprotein.	25.00	25.00	41.50	40.70	18.80	16.70	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.80	0.71	-4.17	9	172	2009-09-25 12:32:18	2009-09-25 13:32:18	3	8	73	0	7	89	0	135.30	45	17.05	CHANGED	a-h.ts.p.th.spGW.passslssppltpsp...WpThplsspp.hlC+Fsa.sssGcptsFVGaV-...sssthCpuuc-hpap.suppp.h.Sp.sDYpLLS.hGc..GpV.oYsPss-lGEssLCoLs+sGss....GAGFlsss	.......F-L.pPcp.EhpLcGW.Qtsssls.tp...h....Nsp......WpTMhls...sppphICRFsYhussGcphpFVGals...tpcplCoGGR-l+ahp.Dtpp..I-SphsDYELLShhGc..GpV.oYsPsspIGEspLCoLspsuss....GAGFl+s.t.	0	3	3	5
+12396	PF12562	DUF3746		Protein of unknown function (DUF3746)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF04595.	21.80	21.80	32.70	37.40	18.20	17.30	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.19	0.72	-7.77	0.72	-4.10	9	53	2009-09-25 12:33:09	2009-09-25 13:33:09	3	1	36	0	0	43	0	36.10	65	9.39	CHANGED	SoFssPpL+ssspsp....sC+KpsFsNSpaTTRTssal	....SSFPVPTIKSVTNKKK...ICKKHCFVNSQYTTRTLSHI	0	0	0	0
+12397	PF12563	Hemolysin_N		Hemolytic toxin N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF07968, Pfam:PF00652. This family is a bacterial virulence factor - hemolysin - which forms pores in erythrocytes and causes them to lyse.	22.50	22.50	25.00	24.50	17.50	17.40	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.08	0.71	-4.86	7	120	2009-09-25 12:33:59	2009-09-25 13:33:59	3	4	81	15	5	93	2	176.30	68	28.55	CHANGED	.KlNpptssh.lslhSulusssshAsIspPsGtAlphhSplpssptlhYhNAu.W.sEcsph.......oLsplR-pVlNQphRhhlDFStIpspspp.sphpsphRpphGluFussFllIoEHKGELLFTPhDss-D.........lsstLLEAsttpRsh..ot.sott...sossETsoLPHVAFYlNVNRsISDpECTFsNS	..........................Kh.ppt.sl.hTILSAlS.SsTlhANINEPSGEAADIISQVADSHAIKYYNAADWQAEDNAL......PSLAELRDLVINQQKRVLVDFSQISDAEGQ.AEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDpAEE.........VDPpLLEAPRTARLL..uRSGFAS..PAPANSETNTLPHVAFYISVNRAISDEECTFNNS.....	0	1	2	4
+12398	PF12564	TypeIII_RM_meth		Type III restriction/modification enzyme methylation subunit	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF01555.  There are two completely conserved residues (F and S) that may be functionally important. This family is a bacterial phage resistance protein. It functions in a type III restriction/modification enzyme complex. It is part of the methylation subunit of the complex. It binds DNA and methylates it.	25.00	25.00	29.50	29.20	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.66	0.72	-3.99	21	216	2009-09-25 12:35:04	2009-09-25 13:35:04	3	4	186	0	19	219	15	56.10	43	11.50	CHANGED	hDcpLlphLLpspp....lKppFFpcl.sshhlFchpcFlchlc.Kca......Lss..SaT+apNKIGL	......D.pLlshLLps-p....lKcpFFhcl....sssLVFchpcFh.hL-p....+p.......lss..SYT+YsN+IGL..	0	7	10	14
+12399	PF12565	DUF3747		Protein of unknown function (DUF3747)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 215 and 413 amino acids in length. There is a conserved DSNGYS sequence motif.	25.00	25.00	141.80	141.50	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.03	0.71	-5.21	38	86	2009-09-25 12:38:19	2009-09-25 13:38:19	3	4	48	0	36	105	45	180.40	40	57.40	CHANGED	hthhhphsslsshslsshhs..ssupAuh.FspptlsQscalslApP...hG..sspapLLllEQI...pspptCWpEpussPs.lV-PLLLsFD...FTGICsRuoDSNGYSlRhuGpDlGhsYpLRlhppss-LlLh....uhs.t.ssssst.lllGRopGh.s...sG.FlKlpLpPGWchs+RoYpG+sLGHlYhusspsss	............hh.....hsslsshslsuhhs..ssspAuhFspptl-QscalslAtP...hG..sspapLLllEQI...ssp+.CWs-sGusPs.hV-PLLlsFD...FTGICsRusDSNGYSlRlsGpDLGhcYhLpllppsu-LlLl....usspt..ssstsp.lllG+opGhu....sG.FlKlpLpPGWphs+RsYpG+sLGHlYhsssps.s....	0	2	21	32
+12400	PF12566	DUF3748		Protein of unknown function (DUF3748)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 120 amino acids in length.	21.70	21.70	22.00	27.50	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.20	11	511	2009-09-25 12:39:24	2009-09-25 13:39:24	3	7	505	0	47	269	3	117.80	83	28.83	CHANGED	AaVGVVTVSPspP.RYsFIHGPEpPDspWpYDFHHRRGVlVt..psGpApsLDAhDITsPYTsGALRGGSHVHVFSPDGsRLSFTYNDHV..MHEhDsphDhRNVGVAlPhpsVss.sKpHPREY	..........AHVGVVTVHPcuE.....K.YVFIHGPENPDETWHYDFHHRRGVIs...EuG....+VoNLDAMDITAP.YTPGALRGGSHVHVFSPNGERVSFTYNDHV..MH.....EhD..........PA....LDLRNVGVAAPaG......P.VNV....QKQHPREY...................	0	4	15	30
+12401	PF12567	CD45		Leukocyte receptor CD45	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 77 and 1130 amino acids in length. The family is found in association with Pfam:PF00041. CD45 plays a critical role in T-cell receptor (TCR)-mediated signaling. CD45 interacts with SKAP55 which is a transcriptional activator of IL-2.	25.00	25.00	25.60	30.40	24.90	17.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.26	0.72	-4.12	10	83	2009-09-25 12:40:21	2009-09-25 13:40:21	3	19	34	0	13	87	0	60.40	47	7.86	CHANGED	TVDYLYscpTKLFTAKLNVNEsVcCsNs.....sCTNNElpNLsECcp.toVolSHNSCTsPsKpLp	.oVcYhYsppoKhFTAcLNVs.-sVcCsss......sC.sNElpNLsECcp.tsVolSHsSCssPtKpl.....	0	1	1	2
+12402	PF12568	DUF3749		Acetyltransferase (GNAT) domain	Gavin OL, Bateman A	lg7	Prosite	Domain	This domain family is found in bacteria, and is approximately 40 amino acids in length. The proteins in this family are acetyltransferases of the GNAT family.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.53	0.71	-4.54	21	619	2012-10-02 22:59:21	2009-09-25 13:41:38	3	2	602	1	54	719	54	121.30	65	95.94	CHANGED	KLTIppLs....phSsQDhIDLuKIW.........Ppps.ptLpttl......sssppLaAARFN-RLLuAscVplpsp..pupLscLpVREVTRRRGVGhYLl....-EshRph..PplppWhhsttshp..chsshssFhpAsGF..stpsstWp	..........................................................................KLTIlRLE....pFS.c.QD+ID..Lt...K.I..W.................P.EYSsS.SL..p..V........D.-.s.HRI.Y.A..A..R.F..N..E...R.L.....Lu..A.V......R..V......T......L......S......G.....T........p..GA......LDSLRVREVTR.RRGVG....QY....Ll....EEV.....LRsN.....P.s.V..Ss.W.W.M.A.D..sGVE..DRuVMsAFMQALGF..TAQpsGWE.......................................	0	7	19	36
+12403	PF12569	NARP1		NMDA receptor-regulated protein 1 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF07719, Pfam:PF00515. There is a single completely conserved residue L that may be functionally important. NARP1 is the mammalian homologue of a yeast N-terminal acetyltransferase that regulates entry into the G(0) phase of the cell cycle.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	517	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.82	0.70	-5.75	32	545	2012-10-11 20:01:02	2009-09-25 13:43:38	3	42	309	0	357	564	23	365.10	30	57.91	CHANGED	hEaSEhlLYpsplltEuGphEcALc+L..cphpppllD+LAlhEh+uchLlcLGRppEAptsYcsLLcRNP-NhpYYcuL.csh..........t..................hspt...p.pshhslYcphsppa.P+usAs+RlPLcFhp.................G-cFcphs-tYlcphLpKGVPSLFsslKsLYs.cspKhsllp-LlptYhp...shpssuphstps....p.ptcssoshhashYaLAQHYsa....hts.......p-..KAlcaI-pAIppo.Pohl-hahsKARIhKHuGDltcAAchM-cARpLDttDRYINoKsAKYhLRsscsccAtchhuhFTRpts..ushssLp-MQChWa.hEsucuahRpt+hGhALK+apsVp+hFsphhEDQFDFHoYslRKholRAYVchLRaEDpLRsHPaYh+AAtsAlcsYlpLaDpP...hsps.......ph..u.........shsssEcKKhtc...Kt+Ks.pp+tcc-ptct.ttppt....tp..ttttttKttsscsct.Ds...DPhGpKLhpop..-PLc-AhKFLpPL.phuspslEsplhuFEVahR+pKhLLALpslppA	....................................................................................................................................................E.SEhhlYp.s.lh......c.....t.......s.hpp....uLphl.....pp...ttphhDthth.Ehp..u.phhhpLs..ph......p-.AtthaptL..phNs.-s..Yattl.psh............................................thhth...ap...ph..t.h....s...p..s..ss+.h.ls.Lphh.......................s.p.p..F.pphhptal.....h..p+.......G.hPshFssl....+....L........Y.......p.........t........K....h....t..h..lt......plh.th.t...................p..t.pt....................p..ss..hh...s.hhLAQHash......htp..........p..hAhph...lp...tAIt..........s...Ps....h.l...-..hahhKu+IhK......+hGph.pAs.phh-pAptLDhtDRalNsKs.sKYhL+s............s....................p...........cA.phhshF.T+tt...................sshtsL.-hQshWa.hcsutua.t..............................t.p..h.................u.ALK+hht.l.pha..h.-DQaDFHsa.shRKhphRuYlphlchpD.lhtp.hah+us.....h.shph.Yhtlh-...p............ttt................t......................t......p...cch.p....p.ppt.t.p.t...tt........................................................t............p...s.t....l.......t.............t.htt.h...p.hh..h...s......t.............s..h..hc....h..t...tt.h..h.....................................................................................................................................	0	119	195	289
+12404	PF12570	DUF3750		Protein of unknown function (DUF3750)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 175 and 265 amino acids in length.	25.00	25.00	36.40	98.40	19.70	17.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.90	0.71	-3.88	33	129	2009-09-25 12:44:47	2009-09-25 13:44:47	3	1	127	0	59	131	32	131.70	45	55.96	CHANGED	tpAlVpVYAA+shuWRGhaAlHoWlls....KtsuuspYsRa-V........lGWGh.....sl+p.sthsPDutWaGutPcllhshcGctAcplIspIcsAlpsYPass..pYcsaPGPNSNTFlAalh+pVPpLplsLPssAIG+DY	...pAlVpVaAApshuWRGhhAVHsWIlh....KctGuspYsRY-V.............luWGt.....slRp.sshsPDuhWaGupPcllsshcGtpApplIPcIcsAlpsYPass..sY+sWPGPNSNTFlAalhRpVP-LplsLPssAlGKDY	0	13	26	39
+12405	PF12571	DUF3751		Phage tail-collar fibre protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two completely conserved residues (K and W) that may be functionally important. The members are annotated as being putative phage tail or tail-collar proteins.	23.00	23.00	23.10	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.80	0.71	-4.40	47	961	2009-09-25 12:45:44	2009-09-25 13:45:44	3	33	662	0	136	906	8	148.70	39	30.54	CHANGED	M...u.....sllTptGcphlAppsutGpslplsphlhAsssG.....s.hssspshsshsphVacsslsph..uhhNsNtVlhshllssslGsF.ashlGLh..sssusLhulspsPpphKhpstpGs...Gpslscshllpao..sspplTtlplssssW.hshtAch.pshD	..........Ms..cahollTshGts.+l.AsAs.A.h..G.p...l.p.lopMAVGDGsG.............shss..P.s..ssQ...T.t.Llpc.hhRuslNpl.....lDsp.N..s..s.tl...l..A.EhlI.P..p..s......h..G...GFalRElGLa....D-sG..sLIAVuN.s.P.E...o.YK...Pt.ltEGS....G+spThRhllhlS..ssssls.LplDsss....lhATpcYVD.........................................................	0	19	59	98
+12406	PF12572	DUF3752		Protein of unknown function (DUF3752)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 140 and 163 amino acids in length.	22.30	22.30	22.30	22.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.04	0.71	-4.09	41	249	2009-09-25 12:46:56	2009-09-25 13:46:56	3	8	209	0	181	244	1	139.20	25	38.15	CHANGED	PPpppshtuhhsss.....RpFspu....+sut.........ssSsWT-TPt-+tcRhppphhuhpstst..........sttttttpsppstc.......ttlcpYscp.pRucSLlppHpccpppptpp..................................pppsssstRsFD+-+Dhplspp..sptpp+chlp+u.tshusRFus	................................................................................RpFpptt......tttts..............spShWT-TPt-+t+....+hp.pp..uhps.s.....................pttpp.thhpt.pcpc................htpplppascp...pRu.cSLh-hHpcchcppttp.....................................pppss.p....p+s..FDR-+Dlpssph....spsp++pllp+u.pplsoRFup......................	0	62	95	141
+12407	PF12573	OxoDH_E1alpha_N		2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00676.  There are two conserved sequence motifs: VPEP and RPG. This family is the alpha subunit of the E1 component of 2-oxoisovalerate dehydrogenase. This is the enzyme complex responsible for metabolism of pyruvate, 2-oxoglutarate, branched chain 2-oxo acids and acetoin. The E1 component is a heterotetramer of alpha2beta2. The homodimerised beta subunits are flanked by two alpha subunits in a 'vise' structure.	25.00	25.00	28.60	28.20	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.06	0.72	-4.41	28	200	2009-09-25 12:48:08	2009-09-25 13:48:08	3	1	198	5	52	156	12	42.80	58	10.39	CHANGED	tssLpLHVPEPssRPG-pPDFSplcIscAGul..RPslsssPt-	...h..sLpLHVPEPssRPGspsDFSal+lstAGsVR.RPsIDspPt.....	0	9	26	39
+12408	PF12574	120_Rick_ant		120 KDa Rickettsia surface antigen	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. This family is a Rickettsia surface antigen of 120 KDa which may be used as an antigen for immune response against the bacterial species.	21.00	21.00	22.70	21.60	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.66	0.70	-5.28	7	128	2009-10-28 17:27:32	2009-09-25 13:49:09	3	1	98	0	11	123	1	227.80	70	29.18	CHANGED	lL+-hhs.hs.-LAEphthc.....-cD++hcsFh....tNsspRphlspAhEssEhKKtLEsIEIsGY+NlhsoaSA........................................................................tstYtGGF+PlQWcNpl.SAusLRuTVlcNDAG-ElCTLsEpThKTpPhhlAKQDGTpVplsSYRpIDFPIcL-c.AsGoMHLShVAhcsDGppPucs+AVYFTAHYEps..PNGpPpLKElSSPpPLKFhGsss-AlAYIEHGGEIYTLsVTRGKYcEMMKEVtlNpGQuVDLSQ..tpDlhcVQGpup	...........................................................ILKDLAALTDRDLAEQKRKEI..EcEKDKTLSsFF....GNPANREFIDKALEsPELKKKLESIEIAGYKNVHsTaSA........................................................................AsGYsGGFKPVQWENpV.SASDLRATVV....KNDAGDELC.TLNETTVKTKPFTlAKQDGTQ.V.QIoSYREIDFPIKLDK.ADGSMHLSMVALKADGTKPSK.DKAVYF..TAHYEEG..PNGKPQLKEISSP.p.P.LKFAGTGDDAlAYIEHGGEIYTLAVTRGKYKEMMKEVcLNpGQSVDLSQ..A...EDlhhsQGtSp...................	0	1	2	2
+12409	PF12575	DUF3753		Protein of unknown function (DUF3753)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are approximately 70 amino acids in length. There is a conserved YLK sequence motif. There are two completely conserved residues (D and F) that may be functionally important.	21.60	21.60	21.60	69.00	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.56	0.72	-4.18	14	56	2009-09-25 12:50:08	2009-09-25 13:50:08	3	1	43	0	0	36	0	71.00	54	97.91	CHANGED	MDKLYsulFGVFhoSsD-.DFppFI-lV+SVLoDcps.tp.pss.s..t..hlllsllhlllllll..hFlYLKlh	MDKLYAAIFGVFMuSs.-D...Dhs-FIEIVKSVLSD-Kosss.osssss.ashaaLIIlhhlVlIllLL..laLYLKVV.	0	0	0	0
+12410	PF12576	DUF3754		Protein of unknown function (DUF3754)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.	21.50	21.50	22.50	21.80	19.60	21.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.87	0.71	-4.55	22	186	2009-09-25 12:53:38	2009-09-25 13:53:38	3	4	103	0	108	188	16	150.90	23	30.01	CHANGED	a-clllhh+...........................................hcssph.tt......................................tppphshtssplhl+lFcslPcsDL-hlFPNt+lshphhDplhlslsulhushslllphlht.hlhlsshh.hh........................hhtslhuhssLuuaha+passYKs+ph+apptlscsLaFKsLssNuG	...............................................................................................................................................................................................................................................ttpttslhlKtFKsIPhsDLEhlLPcp..c.lphs.hDtlhlslsslluhlslhsshhthh.......s..............................hhsslhllssh.s.hhsh+th.h..sFppphspap.hhlscsLY.KslssspG.............................	0	31	67	86
+12411	PF12577	PPARgamma_N		PPAR gamma N-terminal region	Gavin OL	lg7	Prosite	Family	Peroxisome proliferator-activated receptors (PPAR) are nuclear hormone receptors that control the expression of genes involved in lipid homeostasis in mammals.  This sequence region is found at the N-terminus of these proteins. The family is found in association with Pfam:PF00104, Pfam:PF00105. It is not clear if this region is a separate protein domain.	25.00	25.00	27.10	26.10	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.07	0.72	-3.67	8	132	2009-09-25 12:56:48	2009-09-25 13:56:48	3	3	66	0	30	125	0	83.90	64	18.98	CHANGED	MVDT.QhhuWP.VGFGLSulDLsEL-DcSHSLDlKPFoTlDYoSISS...................hcY-ssPsps-.hs+sMDhophYuYch.....................................+hppsQsSIKL	..MVDT.EMPFWP.sNFGISSVDLSsMDDHSHSFDIKPFTTVDFSSISo...................PHYEDIP.........FsRsDPhVsDYKYDL.....................................KLQ....EYQSAIKV.......................................................................................................................................................	0	1	3	10
+12412	PF12578	3-PAP		Myotubularin-associated protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.	20.40	20.40	20.50	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.57	0.71	-4.33	21	204	2009-09-25 12:59:09	2009-09-25 13:59:09	3	9	92	0	111	195	0	124.90	25	18.37	CHANGED	p.pth....s.........hcslssttpph.tss..hht.h.ph....ssspsp.tstspph.ts..ths.......p.pphLpPtptshplplWsQCYhRWhPhtplpsGG.spl.hphphhhsc..l...pclpchlcppchtplsssphc	........................................................................................hP.s.p....tpt.hh..pp.h.hp.......sp......p..sp.tss.cphhcphauhP............ss..cGlLLPt...........hpGscl+lWppCY.LRWlPEsQI.ttGG.sts..p.lp.Lh-E.....l....ppLpctlcptp.t........t...................................	0	19	30	63
+12413	PF12579	DUF3755		Protein of unknown function (DUF3755)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a single completely conserved residue N that may be functionally important.	25.00	25.00	27.80	27.10	24.90	23.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.40	0.72	-4.56	27	109	2009-09-25 13:00:09	2009-09-25 14:00:09	3	2	21	0	64	100	0	34.90	40	12.41	CHANGED	ushp.lp-NlsLhppsRcNIhslLpchs...phPslMsp	.....shp.hp-NlsLFp+sRcNIpslLsc.Ms...phPGIMsp........	0	11	34	49
+12414	PF12580	TPPII		Tripeptidyl peptidase II 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.	25.00	25.00	29.30	28.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.14	0.71	-4.99	24	162	2009-09-25 13:02:15	2009-09-25 14:02:15	3	9	122	1	112	157	4	190.60	42	15.09	CHANGED	l-lp.u.LtsEclpPslsLcphthsh+Psp.uKIpPLu.sRDllP.sG+QlaplhLTYphp.........................ls.cuuEVssphPhlschLYEucFESQhaMlFDsNKphlusGDuYsp................................hKL-KG-YTl+LQlRH-ppplLEKlK-hslhlppKL.s.s.lsLclasshssslsG..stcassttltsGpspshYl.sslss-KLPKsshPG	.........csp.osLphE-.lsPsloLKs............hspsLRPsp.uK....lpPL...............u..sRDl.LP..ssRQlYp............hl.....LTYsF+..........................s.KuuEV.sPpsPlLs...-hLYESEF-SQhWhlFD.p.NKphhusGDAYPc.............................pas.h.KL-.KG....-.YTlRLQlRHEphshLE+L.K-l..shllsc+L..u.ssloLDlapshs..............tAlhG......ppKh..s.shsLsPt............hspshal.ssl.s.cD.KlPKsssP.......................	0	42	59	89
+12415	PF12581	DUF3756		Protein of unknown function (DUF3756)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 40 amino acids in length.	25.00	25.00	36.30	34.80	17.80	16.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.98	0.72	-4.27	18	76	2009-09-25 13:03:18	2009-09-25 14:03:18	3	4	5	0	0	68	0	40.50	88	2.91	CHANGED	lASGYRTN..ALVAPQAKISIGAYAAEWALSTEPPPAGYAIVR	.LASGYRTN..ALVAPQAKISIGAYAAEWALSTEPPPAGYAIVR	0	0	0	0
+12416	PF12582	DUF3757		Protein of unknown function (DUF3757)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 154 amino acids in length.	21.10	21.10	25.60	24.40	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.02	0.71	-3.92	25	155	2009-09-25 13:04:14	2009-09-25 14:04:14	3	2	95	0	19	82	0	109.00	29	78.44	CHANGED	sspsCPulssI.pts........GsYoA..ssssscWhGs..pG.hsptp..lppFppAhhl.tss.t.....t.Gph.pCoYpl.spstplDhhap......spshhholps.pst....Wcpppssh...h.hh.Co..sssscpCpFc	.........t..ppCPshstIp..t......GsYsu....sstpWhG...pss.spts..lppF..Ahhlstst.......s.sth.pCTYtl..tstplDhhat....................hspshhholhs.psh....Wctppssh...hp.hhCo..ssusppCpFs.....	0	2	7	12
+12417	PF12583	TPPII_N		Tripeptidyl peptidase II N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.97	0.71	-4.04	7	69	2009-09-25 13:04:59	2009-09-25 14:04:59	3	7	30	1	23	76	0	126.70	54	20.09	CHANGED	sGuuNsuususuTsAAAA.AsTssusKPKssus..ttsuh..sssAuGDGVssQo-sPsps.sssPuSPKKGKosuD-YuEuLRDFQCoaIsKs-hEhAEKIYp-VltAHPKHLtAHLhLIQNIESspLK.spLPLsFssupcsp	...........................P.PAKKoSSTANATTGAAs.AlTNsATNGN.VANA........GSNGT....GNNVITATNGAA..NGSlPNGTAVK.ENRSKW.DEYCEGLRDYQTAQISKLDA.ENA....ENVYQALLKDNPNHLA...AHLAMADHFDS.TDLK.Q..NLPYTFTAShD.u.......	0	9	12	21
+12418	PF12584	TRAPPC10	DUF3758;	Trafficking protein particle complex subunit 10, TRAPPC10	Gavin OL	lg7	Prosite	Family	This domain forms part of the TRAPP complex for mediating vesicle docking and fusion in the Golgi apparatus. The fungal version is referred to as Trs130, and an alternative vertebrate alias is TMEM1 [1,2].	21.60	21.60	21.60	21.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.90	0.71	-4.70	32	265	2012-10-04 00:47:01	2009-09-25 14:07:17	3	10	233	0	196	280	1	163.40	21	14.07	CHANGED	slslPslphlhsssht.hppssh........................................................................tVGp.lshplplcp.pphWss.t.t..............................p.sh....chhYcl..sss-sWhluG+++Gphph.................ppssphp......hslhllPLtsGaL.hPplplpshs...........................................................tt..sscl..psuuppllVl	........................................................................................................................................h.hP.lphhasspht....p.tt............................................................................hspsGphhshplplpp.sp.hpst.....................................tttst.......chhYEl...hsssssWhlsG+p.pGshsh................................tpssptp............lslhllPLpsGaL.shPslclhphh..............................................................t...ssps..pshu.plhV.........................................	0	49	96	159
+12419	PF12585	DUF3759		Protein of unknown function (DUF3759)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 107 and 132 amino acids in length. There is a single completely conserved residue H that may be functionally important.	25.00	25.00	49.70	48.60	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.07	0.72	-4.08	39	128	2009-09-25 13:08:28	2009-09-25 14:08:28	3	3	85	0	89	132	0	92.90	46	72.33	CHANGED	psacpVh..st........pHcu+hSHELlAGAAuFEAhKsaE-+pc+....................pGKPsSHAhAKElLAGhAGAtlD+lhET.KGLD...alD+-cAK+cAccpscchhcpcY	..............t.tapplh..st......pHcu+hSHELlAGAAuFEAhKAaE-Hpc+....................pGK..PsSHAhAKElLAGhAGAtlD+llET.KGLD...alD..+-+AK+cAccpAcchhsppY.................	0	33	54	76
+12420	PF12586	DUF3760		Protein of unknown function (DUF3760)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 46 and 64 amino acids in length.	25.00	25.00	26.80	25.40	23.90	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-8.25	0.72	-4.12	15	44	2009-09-25 13:09:30	2009-09-25 14:09:30	3	2	3	0	13	37	0	51.60	31	15.26	CHANGED	oL.................sPL.ssVpclIh-cLutlsP..lphLplS...........................................+haY.....................+cllPplY+sVsls	....................LssL.tsVpclIh-pLstlsP..lphlplS...........................................+haY.....................+chlPhlY+pVsl..	0	13	13	13
+12421	PF12587	DUF3761		Protein of unknown function (DUF3761)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 157 amino acids in length.	22.00	22.00	22.10	22.00	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.51	0.72	-3.87	9	145	2009-09-25 13:10:56	2009-09-25 14:10:56	3	3	109	0	45	146	5	71.50	43	53.39	CHANGED	+tsslsuuLhAshhhhshsAaAhs.............stusLspcspYhN+DGtsVHuPA+sh..psPsGATA+C+DGoYSFSpH++GTCSGHGGVspWh	..............................................................................................t............................................................hpAPA.....p....s.P.sGs.T....A.....hC+DGoaShutp..+.+GsCSGHGGVssWh...	0	8	21	32
+12422	PF12588	PSDC		Phophatidylserine decarboxylase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF02666. Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes.	23.40	23.40	23.40	23.60	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.88	0.71	-4.57	45	205	2009-09-25 13:12:22	2009-09-25 14:12:22	3	6	143	0	118	199	5	133.40	35	31.88	CHANGED	LtPslp-hpcLI.......EscstlhhLhspMFpp.........tsssGp..plcsacchLpllNtllspAPpass...........suLlGhPlNAlLDWPMuTsuGashFhcPplNtpLK+lLstWupFLsoPcSs..pVLsss.pt........GWFussAhpphpp	..............tsslp-hppLl.......EssshlhMhhspMhc-...............tsssG.p...t..lcsapchLpllstlh.T.p.APpasp...........sGLlGhPlNAlLDW.................PMsTsuGauhFhcspVNtplKclLshW..s.p.FLp....oPcSt..tsLsss..s........GWhuspAhpph..t...........	0	34	64	91
+12423	PF12589	WBS_methylT		Methyltransferase involved in Williams-Beuren syndrome	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with Pfam:PF08241. This family is made up of S-adenosylmethionine-dependent methyltransferases [1]. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype [2].	21.00	21.00	26.60	25.20	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.29	0.72	-3.50	79	336	2009-09-25 13:14:03	2009-09-25 14:14:03	3	6	300	0	234	315	1	79.90	30	28.36	CHANGED	LhsG...sh.pt.spsts..p..................t.pph.httpp.pttpppct+th.cp.....u.K-WIh+KKEphR++..G+.cVtsDSKYTGRKR+s+	......................................................G.........sth.s..........................p.pph.t.hs.t.pct.ptp.+pt.c.tcth.cp......................o.+sWIlcKKEphRRp..G+.cV+s..DSKYTGRKR+s....	0	82	131	194
+12424	PF12590	Acyl-thio_N		Acyl-ATP thioesterase	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is typically between 120 and 131 amino acids in length. The family is found in association with Pfam:PF01643. The plant acyl-acyl carrier protein (ACP) thioesterases (TEs) have roles in fatty acid synthesis.	22.00	22.00	50.00	47.30	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.99	0.71	-3.68	24	113	2009-09-25 13:15:00	2009-09-25 14:15:00	3	2	47	0	24	123	0	119.70	58	29.72	CHANGED	M.VAouAuSAFFPVs.Sssssusu..........t.....GphssSLs..GlKuKss.souuhQVKANA....pAsPKlNGopVuhpss.cshcp-s...sss...SssPRTFlNQLPDWSMLLAAITTIFLAAEKQWhMLDWKP+R..PDMLlD	....MsAo..sAs.SuFFPls.osussssu.............tp...hGphssolshtGltuKss..ssGuhQVKAsA....QAsPKlNGopVslhss..phpp-c...sss...ussPRTFlNQLPDWSMLLAAITTIFLAAEKQWhMLDWKP+R..PDMLlD.........	0	1	12	19
+12425	PF12591	DUF3762		Protein of unknown function (DUF3762)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF05533.	21.90	21.90	22.20	51.60	21.50	17.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.61	0.72	-3.95	2	72	2009-09-25 13:15:54	2009-09-25 14:15:54	3	3	1	0	0	63	0	78.90	86	6.53	CHANGED	.PSMVAIPVPIuFGshssTAWCS.uDAAVLRCRLsYHAAETsFpspcKHVRYVYNDVSSAANRPRTVSsRKCGpVFPStS	..PPSMVAIPVPISFGshPTTAWCS.A.DAAVLRCRLDYHAAETSFRNE.GKHVRYVYNDVSSAANRPRTVSPRKCGRlFPSGS....	0	0	0	0
+12426	PF12592	DUF3763		Protein of unknown function (DUF3763)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF07728. There is a single completely conserved residue F that may be functionally important.	21.80	21.80	21.80	23.50	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.56	0.72	-4.34	26	649	2009-09-25 13:17:07	2009-09-25 14:17:07	3	2	645	1	56	296	0	56.90	57	11.46	CHANGED	tssphhppLschcpcl+cpRp.......tFpppQPplFIsschLstIEuSLhplscplcphppp	...........h.PuEIKQQLEcLEsDWR+QHs.......hFSEQQ+CLFIsuDWLGRIEASLQDVGtQIRQAQQC...	0	3	14	34
+12427	PF12593	McyA_C		Microcystin synthetase C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF08242, Pfam:PF00501. There is a conserved YAN sequence motif. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases. This family is made up of the C terminal of microcystin synthetase, one of the proteins involved in this synthesis pathway.	25.00	25.00	53.30	52.40	17.40	16.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.02	0.72	-4.20	4	77	2009-09-25 13:18:40	2009-09-25 14:18:40	3	12	60	0	1	68	0	39.10	66	5.19	CHANGED	DVIFspcQspt..+hsLpsFTsTp.Qt....DWQhYANpPLQP+L	DVIFs.hpsp...+tshhsFTPTH.pAKP..-WQhYANHPLps+L	0	0	1	1
+12428	PF12594	DUF3764		Protein of unknown function (DUF3764)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 89 and 101 amino acids in length.	25.10	25.10	25.20	29.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.71	0.72	-4.25	25	55	2009-09-25 13:20:22	2009-09-25 14:20:22	3	1	33	0	17	59	799	83.20	36	88.41	CHANGED	hpToVhTFclossFsEWsthaDupc.pthpcphGIpsLYRGVSc-DPpKlhVlhQA.E.GshppFhpssp..-hIcuuGHlh-oT.hos	.....EToVhsFclossF-EWtthaDup-.pthacphGlpsLaRGhSp-DPp+lhVlhQus-.Gshpphhpssp..chlpuuGHlh-oThho.h..	0	1	7	13
+12429	PF12595	Rhomboid_SP		Rhomboid serine protease	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with Pfam:PF01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.	25.00	25.00	61.90	56.20	22.80	22.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.56	0.70	-4.73	31	130	2009-09-25 13:20:38	2009-09-25 14:20:38	3	5	50	0	58	113	0	199.70	59	25.43	CHANGED	VSKDs-ST.Q+WQRKSlRHCStRYG+LKsQVhREL-LPSQDNlSLsSTETPPPLYlsspp.....hGMQKIlDPLA...RGRAFRhs--.sD..G.SsPHT......PlTPGAASLCSFoSSRSGasRLPRRRKRESVA+MSFRAAAALlKGRSlhDuThpRsp..RRSFsPASFLEEDosDFsD-LDTSFFuR-shhp..EEhSohPD-VFESPu-uAhKphtps..s-pssLTGuALD.....+	.......VScD.-up.Q+WQR....KSl+HCS.RYGKLKsps.REL-LPSQ-ssShpuTEoPsPhhls................KIlDPLA...RGRAFRhsD-.sD.....t.psP...Hs..............PlTPGshSLsSFoSsRSGas+LP.RRKRpSVA+MSF+AAAALlK..GRS..Vh-..u..T.h.pRsp...+RSFs.sSFlEEDsVDhsDphDoSFF..u.......+..hh......EEhSohPD-VFESPs.uA.h.hths...sp.ss.sGstl..................	0	3	7	21
+12430	PF12596	Tnp_P_element_C	87kDa_TransP;	87kDa Transposase	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 78 and 110 amino acids in length. The family is found in association with Pfam:PF05485. There are two completely conserved residues (D and G) that may be functionally important. This family is an 87kDa transposase protein which catalyses both the precise and imprecise excision of a nonautonomous P transposable element.	22.60	22.60	23.10	22.60	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.77	0.72	-3.71	11	61	2009-09-25 13:22:20	2009-09-25 14:22:20	3	3	21	0	20	62	0	83.40	39	15.90	CHANGED	ssscpspp-pals....oopp.cspspppp.........lph.................t.s-Esps.......th.ss.ss.h-hsE....pcDulEYlsGYlh+Kh+.......Lu-hsppsso	...........................................................NltpDNs-sWLN.hs...o.psppcsc.sp.......................................shscEs.-..........phhsNl-h.h-hDE.........LTEDAhEYlAGYVl+KLR.......luspsppp..hs...............	0	3	3	20
+12431	PF12597	DUF3767		Protein of unknown function (DUF3767)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 199 amino acids in length.	25.00	25.00	30.40	26.90	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.54	0.71	-4.43	31	226	2009-09-25 13:23:46	2009-09-25 14:23:46	3	2	207	0	158	219	0	110.60	25	72.96	CHANGED	Psc.ss.....................sps.......tt.pc..olp-Ahcols.hsDF..tphhphPChR-uhlsGhuuhhslGulphlhtt..shhpA.sNWuVGuFhLuulsuaE.CphpRcpphpthppAhchhtc+ctcphccp.pp	........................................................................hpthp.h..sh...hsltphPChR-uhLhGhuuuhshGslpFlhsu..phtpu.ssauVGuFhlsolusW.hCphp...ptppp.thp.shchhtph..........t.............................	0	46	80	124
+12432	PF12598	TBX		T-box transcription factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 77 and 89 amino acids in length. The family is found in association with Pfam:PF00907. There are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates	20.10	20.10	20.60	25.40	19.10	20.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.30	0.72	-3.61	15	119	2009-09-25 13:25:01	2009-09-25 14:25:01	3	2	42	0	52	109	0	84.90	42	13.25	CHANGED	RhYEEppK.t+-susSDcSSuEtssh+..cpss..SPsuussush+l+c.............sS+D-+.tsssss........schpsss--csspssSPutpt	........RlYEE+.pK..+-susSDtSSsE.ssh+..spss..SPh.s.ussus.pL+c..................ps+-E+.stusss........sc.pppopEcsstshu.....s...................................................................	1	2	7	20
+12433	PF12599	DUF3768		Protein of unknown function (DUF3768)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 108 and 129 amino acids in length. There are two conserved sequence motifs: NDP and RVLT.	25.00	25.00	37.60	37.60	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.91	0.72	-4.07	41	95	2009-09-25 13:25:45	2009-09-25 14:25:45	3	1	59	0	32	104	44	83.50	41	66.99	CHANGED	hhTpGltuL........upp.h.....tpllptVpsFDsFss-NDPaGEHDFGsl................chtGppl..aWKIDYY..DhshpauSsDPuDsslTtRVLTlMLAsE	........................hTtGltuL........utth.........tpllctVtsF-sFss-NDPaGEHDFGsl................ch....pGppl..aWKIDhY..Dhsh.....paGSs-PuDsshTtRVLTlMLAsE.......	0	9	26	29
+12434	PF12600	DUF3769		Protein of unknown function (DUF3769)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 560 and 931 amino acids in length.	20.50	20.50	20.60	20.90	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.44	0.70	-5.67	39	99	2009-09-25 13:26:29	2009-09-25 14:26:29	3	5	90	0	50	103	251	383.70	26	53.78	CHANGED	tssGplsRhRFpAs+lphsscG.WcApchphTNDPFoPsplclcAcssphpp.ss..sc..lpsppsRLll-p+lslP..l.pcphl..pcp...c-.......shhshGaDscDRs....GhFltRshsslp.ssshpLplpPQahlQRAlpsts.s............sppsssh..s-hFGLpucLsuphs..shphpspuslooh.sh-c.hpsshRhpsclppsls..h.sshphsh.hsYRpRlaNGSLG.psV.uuhGuhl............p.................sssh...sssulphsYp......huhthsshps-ph...........psss..........hssLhRhphhuSLspsasLWpGc.shs.TsppuhR.YoPtPllPhlsl.....sTslsushuhYu...sGss.QsoLshosG.phplGpFS+sahDYTthslshutslpsGt.SPFhFDRhlDhtsLshGloQQIYGPlhlustsulNlDs.....GchlsophtLcapRRoYslslhYNPhpplGulphRlsDFN	.................................................................................................................................................................................................................................................................s..stlpphRhputplph.sps.WpupphthoNDPasPsphclputps.h.t.ss...c..l..ptspllh-pthshP..h..pp.h..ppp.p........h.hGhDst-+s....Ghaltpthp.lp.stsh.hplpPQhhlQ+uh...............................tt.tsh..sshaGl.schpsphs..phphp.psp.lssh.s.sp.htst..Rhphphppp...........hs............hphph.hs.YR.RhaNGoLG.psl.puhGshlt.................p......t.sshthsa.......htht.hphps-p......................pspphhshhRhphhsolspth.lWpup.shs.ssppuh+.YoshslhPhltl.....................ssslpushuhYs...sGpp..Qss....ltuolGhshQhGpFo+sahDYTt....hs........ls........h..........utshh........s.....Gs.S........P....F.hFD+hsD.......ht.........s.......L.......shulsQQlhGPlhhssposlslDs..........sp.hsop.h.lpap+...R...oYtlhhhYsPh.phGuhphRls-Fp...........................................	0	11	33	45
+12435	PF12601	Rubi_NSP_C		Rubivirus non-structural protein	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF05407. The rubella virus (RUB) nonstructural (NS) protein (NSP) ORF encodes a protease that cleaves the NSP precursor (240 kDa) at a single site to produce two products.	21.60	21.60	80.10	80.10	20.80	17.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.19	0.72	-4.08	3	69	2009-09-25 13:27:13	2009-09-25 14:27:13	3	2	10	0	0	72	0	55.10	100	3.83	CHANGED	VCAVGGGPRRVSDRPHLWLAVPLSRGGGTCAATDEGLAQAYYDDLEVRRLGDDAMARAALASVQRP	VCAVGGGPRRVSDRPHLWLAVPLSRGGGTCAATDEGLAQAYYDDLEVRRLGDDAMARAALAuVQRP	0	0	0	0
+12436	PF12602	FinO_N		Fertility inhibition protein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 62 and 102 amino acids in length. The family is found in association with Pfam:PF04352. The FinOP (fertility inhibition) system of F-like plasmids consists of an antisense RNA (FinP) and a 22 kDa protein (FinO) which act in concert to prevent the translation of TraJ, the positive regulator of the transfer operon.	25.00	25.00	49.70	48.80	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.57	0.72	-3.68	3	274	2009-09-25 13:28:13	2009-09-25 14:28:13	3	2	214	1	3	135	1	61.60	89	33.64	CHANGED	MTEQKRPVLTLKRKst.EGTAPVcuo....suPGhVpRKKlVVVoTPPAWKVKKQ.........KLsEKAARcAE.................AAARKAAPcP	..MTEQKRPVLTLKRKT..EGETPVRS............RKTIINVTTPPKWKVKKQ.........KLAEKAAREAE.................LAAKKAQARQ.............	0	0	0	2
+12437	PF12603	DUF3770		Protein of unknown function (DUF3770)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 250 amino acids in length. The family is found in association with Pfam:PF04196.	21.50	21.50	21.90	66.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.53	0.70	-5.26	6	138	2009-09-25 13:29:41	2009-09-25 14:29:41	3	2	49	0	0	162	0	244.00	40	10.83	CHANGED	ss--scEllaRaRLARslh.EL..+pl.Pth.cuDEsls+ppRElpuh.hpuIpI...DWplTEuKF.sPFo+chF-+Fss..hpsDp-Ylu+Ilpcssccuhccl-+spahs-slspptRh-+NuEpuhstlppKhsphpuapphc-hpc..HKSTVQhPshls+....sussspsLpsLpsls....spGsHPhpclWcp.lsssss.lpcIERh+-Ds.hELchAhuuloc+s.E.....RNKYHRssLshs.--+lYlAhlGVs	.....ssEAEEllYRaRlAhplhscL..R........ssDpELsKoEcELLAh.lpuIph......NhshsEusF.PPho+EMa-+FhS..oPsDs-YIT+llStp.lpop-cLhsspahtcssstthRhp+Nu-Es..thpcsLpphput.c.s.+shss..pKuTlQLPPWLsh....hss-upDlsshpGh-....shtDH.PhspLWcc.slssss...LppIEchH.sDsAtEL-hAlSsst.-+s-E.....Rs+Y+Rs+LshuSc-plYhAthGVs..	0	0	0	0
+12438	PF12604	gp37_C		Tail fiber protein gp37 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is typically between 49 and 166 amino acids in length. The family is found in association with Pfam:PF03906. In T-even phages, gp37 and gp38 are components of the tail fiber that are critical for phage-host interaction.	21.70	21.70	21.80	22.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.86	0.71	-4.42	9	109	2009-09-25 13:31:37	2009-09-25 14:31:37	3	18	66	6	4	116	1	139.60	26	22.38	CHANGED	tssh.s.lp.......lpss.th.......pus.pt..a....cssstpthalu.tGussssDsoh..........hpss.h.hsc..h.sts....sGshpsscWt...ppWLsspL.p.....t.hh............................................hhs..th.t.sshs.hph...us.....sushhlsshuGhh	.........................................................sthsGphplpsspsh......hpuusstutalhu.+ssstssWYlGpGussssDhs.Fashh.h..so.tlt.........lpp..shhshN.c.htlGtAh.ltssGsI.Gohht...staLsshlps......t.h.................................................................................................................................................................................................................................	0	0	2	2
+12439	PF12605	CK1gamma_C		Casein kinase 1 gamma C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 54 and 99 amino acids in length. The family is found in association with Pfam:PF00069. CK1gamma is a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells.	21.20	21.20	21.40	21.30	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.22	0.72	-3.42	17	249	2009-09-25 13:32:50	2009-09-25 14:32:50	3	3	74	6	101	230	0	69.50	50	17.15	CHANGED	+...............hsTPsGshps...-sssos......sR-pp.hhpp.....................t..ppN...............................................t.QsloSTNG-LN.sDDPTuGHSNsPI	...................................hsTPVGulp....-sshSs......sR-tHthps+..............................pN...........................................t.t.............sps.QVV.SSTNGELN.sDDPTAGHSNAPI.....................	0	15	25	51
+12440	PF12606	RELT		Tumour necrosis factor receptor superfamily member 19	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 49 and 288 amino acids in length.  There are two completely conserved residues (K and Y) that may be functionally important. The members of tumor necrosis factor receptor (TNFR) superfamily have been designated as the "guardians of the immune system" due to their roles in immune cell proliferation, differentiation, activation, and death (apoptosis). The messenger RNA of RELT is especially abundant in hematologic tissues such as spleen, lymph node, and peripheral blood leukocytes as well as in leukemias and lymphomas. RELT is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1.	28.90	28.90	29.30	29.20	28.70	28.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.41	0.72	-4.82	17	207	2009-09-25 13:33:46	2009-09-25 14:33:46	3	1	110	0	84	175	0	48.90	35	22.33	CHANGED	YhhhllVslFhlhGLLGlhICplLKpKGY+Cos-s.-sp..pccppttc......p	.....hhhhllVslFhlhGLLGlhIC...plLK+KGY+Cos-c.Esps.tstp......p.................	0	6	17	30
+12441	PF12607	DUF3772		Protein of unknown function (DUF3772)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00924.	25.00	25.00	28.20	26.80	23.60	22.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.85	0.72	-4.33	69	289	2009-09-25 13:35:58	2009-09-25 14:35:58	3	3	288	0	87	297	69	63.60	29	7.86	CHANGED	phActhhscAssLhspIsplhRsphsppLhpRusSPLsPshWssshpshspshpplts.ssphh	............ppApthttpApsLsspIsplRRshhpspLstRusS.LuPsFWsslhpshscDhp+Lpshtsp..h.......	0	12	37	61
+12442	PF12608	DUF3773		Protein of unknown function (DUF3773)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are approximately 110 amino acids in length.	19.90	19.90	19.90	26.00	18.70	17.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.27	0.72	-3.95	5	53	2009-09-25 13:37:22	2009-09-25 14:37:22	3	1	51	0	6	43	6	101.50	63	75.38	CHANGED	h-l++plchlAcshsAcF.................sLcuRploYDEV.FSDTGLLPA...........LsRRADQLsS.LCLGYGlGsoa--AEsALLGV+ssFDEsTP-uLRLhChhDVlsELMpuusuh	..........t.DIpKsMuhIAAuhNAKF.................YLNDRFVSa-EV.FSDTGLLPA...........IA+RADQLCS.LCLGYGLGATaDEAEsALLGlRVVFDEVTPNsLRLLCMTDVlNELIQGGPS.R..	2	3	4	6
+12443	PF12609	DUF3774		Wound-induced protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 81 and 97 amino acids in length. The proteins in the family are often annotated as wound-induced proteins however there is little accompanying literature to confirm this.	27.30	27.30	32.80	31.10	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.91	0.72	-3.13	44	190	2009-09-25 13:38:21	2009-09-25 14:38:21	3	2	24	0	125	175	0	75.20	42	81.28	CHANGED	lAuSluAVEu..lKDQ...thsRWs.shR.Slpppucsph.tshststt....tsutt............sssttspptcpsEESLRpVMYLS.CWGP	................................VAhSlGAVEA..LKDQh...GlCRW.NaALR.SlpppA+s...ss....tu.h....upup+.....hsuus...............ussspcc+tcpuEEuLRsVMYLS.CWGP..........	0	6	76	103
+12444	PF12610	SOCS		Suppressor of cytokine signalling	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF07525, Pfam:PF00017. The suppressors of cytokine signaling (SOCS) family play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms.	20.60	20.60	20.70	20.60	19.60	17.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.06	0.72	-3.64	17	118	2009-09-25 13:39:11	2009-09-25 14:39:11	3	5	41	0	58	93	0	55.20	45	12.19	CHANGED	pspsstp.......+p-Rppussultshstthp.....pt.st+uhusRSLRQ+lQDAVGpChPl+oppppp	.......................scssLp.......ppER+ausSSl.....th......Dpssu+phsuRSLRQ+LQDsVG.CFPl+spupp.........	0	5	12	25
+12445	PF12611	DUF3766		Protein of unknown function (DUF3766)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 20 amino acids in length. There is a conserved FTNID sequence motif. There is a single completely conserved residue T that may be functionally important.	21.10	21.10	21.90	21.10	19.00	20.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.42	0.72	-6.76	0.72	-4.42	43	199	2009-09-25 13:40:01	2009-09-25 14:40:01	3	1	191	0	76	173	5	23.90	55	18.69	CHANGED	TVITAhDppphc.sNVFTNIDSAVl	.TVlTAhDppphK.-NlFTNIDuAVI...	1	40	68	73
+12446	PF12612	TFCD_C		Tubulin folding cofactor D C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 182 and 199 amino acids in length. The family is found in association with Pfam:PF02985. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerise with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules.	21.70	21.70	21.80	23.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.23	0.71	-4.88	48	307	2009-09-25 13:41:32	2009-09-25 14:41:32	3	9	222	0	228	309	4	174.30	25	17.26	CHANGED	ssphsppllsslh+QusEKlD+lRtpAspsLpplh.ptst.........................................t.Lpchhs.pp.t.............................................assssphF...splh.pL..Lsls......................happs...............llpGLssSsGu.hoE.ulh+suppALlpalpt........pppppthttlhssllpllp......cptps-Rlsl.PhlchlshLLss.thht.h..pp.t....hhppLhphlppphhp...op.....sht+	.........................................p....hpplhsslhp.usEKlD+hRttAtpshhpll.ptp.s................................h..........l..th.........ttLpp.lhs.stht...............................................asssppsF.stlh.pL...Lt.l..s........................sYpht................lltGLlsSlGu..loE.Sll+top.tuLhpahp............................ppp.pthtthspsllplhp...................pph.ts..-R.......lhl...PhlchlshLlss.shhp.........h.t.t.............h.plhthhppthht...ttsh........................................................	1	108	145	192
+12447	PF12613	FliC_SP		Flagellin structural protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00669, Pfam:PF00700. This family is the bacterial flagellin structural protein. It is involved with cell motility.	25.00	25.00	61.00	61.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.70	0.72	-3.75	9	66	2009-09-25 14:21:04	2009-09-25 15:21:04	3	3	42	0	11	43	1	57.00	69	15.32	CHANGED	suTuGTGTAVs.........................sLoLsouAT....uuhoAAptoAhsNulAQINAVNpPsTVSsLDIST	.u.oTAGTGTAso......................TLuLSToAT....SuLSAsDQAsATAMVAQINAVNKPQTVSNLDIST.	0	1	2	8
+12448	PF12614	RRF_GI		Ribosome recycling factor 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 130 amino acids in length. There are two conserved sequence motifs: LPS and LKR. Overproduction of ribosome recycling factor (RRF) reduces tna operon expression and increases the rate of cleavage of TnaC-tRNA(2)(Pro), relieving the growth inhibition associated with plasmid-mediated tnaC overexpression.	24.70	24.70	24.90	38.00	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.76	0.71	-4.33	21	130	2009-09-25 14:24:29	2009-09-25 15:24:29	3	1	128	0	22	78	3	124.00	55	96.85	CHANGED	hcpsIoIsLPSLIHRIGp-ssKpApslAtphsC-LKRVRRSRNWplsGcAhplQuFtppL+sp..............pspphpaLIpKl-suLhpHuDKLEPLpsKLhRLlppNPsITLAELMptTpCTlsEARsARFsu-s	.............p.cpsIsIoLPSLIHRIGu-sVK+hKh.AppacCELKRIRRSRNWQLlGEAtshQpFlhplKpp..............Ehp.shcYLI++lEsuLth.uDKlEPlEspLtRLlpQNPuITLAELMutTcCSLhQARsARFstE....	0	3	5	15
+12449	PF12615	TraD_N		F sex factor protein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 96 and 107 amino acids in length. The family is found in association with Pfam:PF10412. TraD is a cytoplasmic membrane protein with possible DNA binding domains. It is part of the bacterial F sex factor complex.	25.00	25.00	26.00	33.90	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.00	0.72	-3.66	24	278	2009-09-25 14:28:23	2009-09-25 15:28:23	3	7	186	0	20	265	0	98.40	51	15.94	CHANGED	hhhhhhhlllsslhhahchstp...shhsuhhYahsp.....hhthl..s.p.hhpltap......spphptohtphLps.ahltss....sphhptlhhuulhuhllshllhhl	....YsLFIhFWILlGLlLWl+ISWQ...TFlNGsIYWWCT.TLEGMRDLI..+.SQPVYEIQYY......GKTaRMNAAQVLHDKYhIWCG....EQLWSAFVLAulVALVICLITFFl........	0	0	2	12
+12450	PF12616	DUF3775		Protein of unknown function (DUF3775)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. There is a single completely conserved residue G that may be functionally important.	21.90	21.90	22.10	27.40	20.90	19.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.44	0.72	-4.19	44	175	2009-09-25 15:18:47	2009-09-25 16:18:47	3	1	164	0	55	130	14	75.40	46	51.75	CHANGED	hsppElcshIssLs--Eps-LVALhWlGRG..-aps-EascAhppAtppt......ssssucYLlGpPhLuDaLEpG........L-u.LGh	.....scpELtuhIssLsEDEph-LlALMWlGRG..DasssEW--AlspApcct........sscsAcYLlGpPhLuDaLE-G....LsA.LG...........	0	14	33	39
+12451	PF12617	LdpA_C		Iron-Sulfur binding protein C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is typically between 179 and 201 amino acids in length. The family is found in association with Pfam:PF00037. LdpA (light-dependent period) plays a role in controlling the redox state in cyanobacteria to modulate its. circadian clock. LdpA is a protein with Iron-Sulfur cluster-binding motifs.	20.60	20.60	24.10	23.20	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.22	0.71	-5.02	45	96	2009-09-25 15:24:46	2009-09-25 16:24:46	3	8	89	0	42	102	157	186.40	40	51.44	CHANGED	sLltphssDAlEIHTpsG+tpsFppLWpslssstspL+hlAlSCst.u.............csLlchLhphapllp..s..............s..hhlWQhDGRPMSGDIGs.GTo+uAlpLup+l.....hstt...PGalQLAGGTNspTlshLcp.sh.........................................pthlAGlAaGuaARpLlpPlLcphcppt.p...............................Lc-hP-hltpAlphApuLVsPh	...............LlpphslDAlEIHTpsG+tptFppLWpplssshspL+hlAlSCst.s..............csllchLtphapllp.s....ls..........t...h.lWQhDGRPMSGDIGp.GTT+sulpLup+l.......hstt.......PGalQLAGGTNsaTlstLcp.sh................................................................pshluGlAaGuaARpllsPlLcphpppttp...............................Lc-aP-hlhpAlphApuLVsPh......................	0	7	28	39
+12452	PF12618	DUF3776		Protein of unknown function (DUF3776)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length.	25.00	25.00	30.90	29.70	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.26	0.72	-3.51	10	168	2009-09-25 15:27:22	2009-09-25 16:27:22	3	5	35	0	61	137	0	105.10	32	20.21	CHANGED	sssppcDc.shshh.tchscK.-psoS...ucsh.slSppspscsuh.-sEs.lucpcppppGsshQhc+SRuuclTushuoc..hh.s.pssccK-cspthssssscul.S.p.p	................................hssKK-ctstsh.tss-t.K...K.-p.sos.....SEsF...ulutcsl...PKsshspsEs.locpc+pppGsuhQhc+uRhsclTushssc...hh.s.pspc+K--s.pthssh.s.pp..ul.S.p..................................	0	3	6	15
+12453	PF12619	MCM2_N		Mini-chromosome maintenance protein 2	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 138 and 153 amino acids in length. The family is found in association with Pfam:PF00493. Mini-chromosome maintenance (MCM) proteins are essential for DNA replication. These proteins use ATPase activity to perform this function.	21.30	21.30	21.60	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.58	0.71	-4.24	58	331	2009-11-26 14:18:40	2009-09-25 17:02:30	3	9	280	0	227	319	0	142.50	31	16.94	CHANGED	---.-t...............-..t-l.t-h...p-h-c.t...E-.--G.DLauDshEc.DYcsp......c.DpY-ts.s..lD.D....-t-hc-hshusRRthEtpLscRD+.httt..............h..thah..s--....---Dsphp.............h.....RRRR+pa-c....-.-sh..sht..-........................hp-ElslEsL....sDlKupol	.....................................ts.......................p.......h.p...t.t...pE-E-G--Lhu.Ds.h....Ec.DYRshs......-hDpY-sp.s........lD.D....-.-h.-.-lshusRctsEtphpcRDRphupt.......................phh.shhh.....ss.-...........----tp.t...........................pR+R+ph-c..........tp.st.....th-..-..........................h.-..olEsLtDhKupo...............................................	0	76	121	188
+12454	PF12620	DUF3778		Protein of unknown function (DUF3778)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 48 and 61 amino acids in length. There is a conserved LRF sequence motif.	22.10	22.10	23.70	22.40	17.60	15.60	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.09	0.72	-4.41	19	53	2009-09-25 16:06:54	2009-09-25 17:06:54	3	4	3	0	34	41	0	51.00	35	17.06	CHANGED	st.shhtsuhthtssshhh.sS.p.+sthllRVE...s.......s..LhLLRFNsELRGsh..LL	....................hh.ssh..t.s..hh.sS..shHsthslRVE...........s..LhLLRFNs-L+Gs.hL........	0	0	0	12
+12455	PF12621	DUF3779		Phosphate metabolism protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF02714. There are two completely conserved residues (W and D) that may be functionally important. This family is likely to be involved in phosphate metabolism however there is little accompanying literature to confirm this.	22.10	22.10	23.20	22.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.16	0.72	-4.10	64	338	2009-09-25 16:07:58	2009-09-25 17:07:58	3	13	128	0	268	348	0	94.10	28	9.75	CHANGED	FhcPchatsactl+phlPpshth......phs.cht.cpAYhpPul.supsPhlWIPRDs..hGlScpElpcspcs.....lsloD-sAthsE.....K.G+lha.......tspPP...ac	...........................................hpPth..sat.h+thh.t............phssphh.ppAYhpPul.puppPhlWIPRD.s..hGlScpElpcspch............l.loDEsutlDc.....K.s+lha.......sttPP.a....................	0	57	138	226
+12456	PF12622	NpwBP		mRNA biogenesis factor	Coggill P	pcc	Wood V	Domain	The full-length Wbp11 proteins carry several copies of a PPGPPP motif throughout their length. This motif is thought to be necessary for folding of the molecule as it helps to bind the WW domain, Wbp11, Pfam:PF09429 [1]. This domain together with Wbp11 may function as components of an mRNA factory in the nucleus.	25.00	25.00	27.30	26.20	23.70	22.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.80	0.72	-3.48	27	69	2009-10-16 11:54:12	2009-10-15 17:08:00	2	4	67	0	48	62	2	63.90	30	21.31	CHANGED	sp+SlYYcPphNPhGtsPsG..........hP.hh+shtt......sp.sp...............hsp............................lshPp	..sp+SIYYcPshNPhGssPsu..........hP.hh+stpt.t.....sp.ss.........................................hpp............................I.hP.....................................................................................................	0	22	32	45
+12457	PF12623	Hen1_L		RNA repair, ligase-Pnkp-associating, region of Hen1	Coggill P	pcc	Gardner P	Domain	This domain is the N-terminal region of the bacterial Hen1 protein.  This protein forms stable hetero-tetramer with Pnkp. The hetero-tetramer was able to repair transfer RNAs cleaved by ribotoxins in vitro [1]. This domain provides the ligase activity of the hetero-tetramer.	20.70	20.70	20.80	27.40	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.57	0.70	-5.60	27	120	2009-10-15 16:15:24	2009-10-15 17:15:24	2	5	118	0	59	128	2	241.90	54	50.93	CHANGED	MLLTloTT.....cpP.ATDLGaLLHKHP-RlQoFshuhGpAHVFYPEAotcRCTsALLL-VDPlsLV...Rsp+ut...su.s.huLuQYVNDRPYAASShLuVALucVFpTAhsG+CcsRPELAusslPLclclssLPs.R..GGtpLlc+LFEPLGWp.VsApslsLDpsaPpWGcS+YlsLsLpG.slRLu-hLsHLYVLlPVLDssKHYWVusDEVDKLlRtGcGWLusHP-+-LIsRRYLt+ppsLscpA.....LsRLs-s	...........................MhLTloTT.....ppP.A....TDLGaLLHKHP-+sQsFshuaGpAHVFYPEAos-RCTAALLL-VDPlsLV......Rspctt........ssss..suLuQYVNDRPYAASShLuVAlupVFpoAhsGcCcsR.PELAspslPLclclPsLPs.R.........G..G.....spll..c+LFpPLGWs.VsupslsLDtpF........Pp...WGcSRYlpLsLpG.plRLuDALpHLYVLLPVLDcsKHYWVusDElDKLLRtG-GWLssHPE+cLITcRYLp++tuLscpAhpRL...h.........	0	22	46	54
+12458	PF12624	Chorein_N		N-terminal region of Chorein, a TM vesicle-mediated sorter	Coggill P	pcc	Pfam-B_PB000002 (release 24.0)	Family	Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.32	0.71	-4.56	121	1194	2009-10-16 09:35:15	2009-10-16 10:35:15	2	56	295	0	818	1223	15	109.70	25	4.37	CHANGED	hE...ulls...plLspaLGp....Yl..cslssppL.plu.lasG..cVpLcNLcLKp-....uLcpL..pLP..lplptGhlGc..Ls.lplPWps.L..tsc.PVhlpl-slal.lssPps....tpchst-c.ppppptth....KtpplpphE	.......................................thlt.lLppaLup...al..c..s..l....s......cpL.pl.u....l.h....p...G......sl.pLpNLpL+.....pc.........................s....L.p...........p...h........cLP.............lplppGhl..s..c..........ls..lp..............l.P.Ws..p..L..............hsc...Plh..lplcslhl.lhtstt.........t.p.p.t........................................................................	1	329	455	664
+12459	PF12625	Arabinose_bd		Arabinose-binding domain of AraC transcription regulator, N-term	Coggill P	pcc	Pfam-B_PB000001 (release 24.0)	Domain	AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, Pfam:PF00165, and this dimerisation domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	22.60	22.60	22.80	23.40	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.12	0.71	-4.47	221	2712	2009-10-16 10:27:52	2009-10-16 11:27:52	2	8	847	0	796	2533	293	180.40	18	52.86	CHANGED	Gh-spslLpps..Gl..ss...sh..L..ps..thp.lshpphtpLhptu.hptssc.sslGLchu.pphphsshGhluhshhsusTLtpAlpphh+ahtlh...hhshph......ttttt....stlth.t....................pt.......h-hhhushhphh..ph..lh...sp.hs.hplphp..assP...s.t....ap..phF.s.ss.lpFststs.s.lhhssph..Ls.tPl	..............................................................GhssttlLtts..Gl.....s......t....l..t.....p.....s...psp...lsh.tp.hhplhpth...hp.hh....s....c....ss..h....G..l.p.....hu.p.p.h..ph.s.sh.G.h.luhsh.h.s.us...oLtpAlpthh.cah....plh..ssh.hphpl..........................ptpssh..stlph..p.tt..............h..............pth...h...h-.h.h.lsshhphh.........ph.lh.....upp...ht....h..plphs.......h..stPs.....thp......tYp.phF...s....ss.lpF..s.psts...t.....lhh..stph..Lshs...................................................................	0	161	340	592
+12460	PF12626	PolyA_pol_arg_C		Polymerase A arginine-rich C-terminus	Coggill P	pcc	Pfam-B_105 (release 24.0)	Domain	The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.	22.00	22.00	24.00	23.10	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.63	0.71	-4.49	70	1295	2009-10-19 10:32:25	2009-10-19 11:32:25	2	4	1278	7	247	869	313	125.80	44	27.24	CHANGED	pppG..hsshsAhppAsscllspQspphAIP+RFohshREIWpLQ.RLs..+RpG+RshpLlpHPRFRAAYDFLlLRspu.G-......phtpLupWWscaQpsssp..p+pphlpphstpttt.........p+RRRRs+++ps	......................csGLs.aDAh.shAhN-VLD-ts+s..lA.IP+RhTshhRDIWpLQhRhs..RRp...G............KRA.a..+LlEHPKFRAAYDhLtLRA-l.tss.......-hpcLupW....Ws-FQsusss...pp.csMl.splspcss.s..........................+RRpRRsR+p..s.............................................	0	50	124	193
+12461	PF12627	PolyA_pol_RNAbd		Probable RNA and SrmB- binding site of polymerase A	Coggill P	pcc	Pfam-B_105 (release 24.0)	Domain	This region encompasses much of the RNA and SrmB binding motifs on polymerase A.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.53	0.72	-4.40	312	6138	2009-10-19 12:08:10	2009-10-19 13:08:10	2	37	4516	22	1489	4542	2033	63.10	27	14.21	CHANGED	sFpI-tcTtpuIpchus..hLpplusERlhcElhKllhus.psptshchLhctGLh.phlh..Ppl.sth	.......................sFplss-Thp.sh..p..p...h...ss.......hL.p...p....l.o.....s.....E....R..lhpEhpK.l..L.h.........us..psptshphL.p.c.hslh.phl.h...Ppl....hh..................	0	481	941	1254
+12462	PF12628	Inhibitor_I71		Falstatin, cysteine peptidase inhibitor	Coggill P	pcc	MEROPS_I71	Family	This family of peptidase inhibitors is expressed from plasmodial protozoal species. Falstatin is found to be a potent reversible inhibitor of the P. falciparum cysteine proteases falcipain-2 and falcipain-3, as well as other parasite- and non-parasite-derived cysteine proteases, but is only a relatively weak inhibitor of the P. falciparum cysteine proteases falcipain-1 and dipeptidyl aminopeptidase 1. Thus, P. falciparum requires expression of falstatin to limit proteolysis by certain host or parasite cysteine proteases during erythrocyte invasion.	22.10	22.10	23.20	63.40	21.50	18.30	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.23	0.71	-4.60	4	9	2009-10-19 12:24:47	2009-10-19 13:24:47	2	2	8	1	6	11	3	162.40	42	31.47	CHANGED	DppYpLsGsEpCDs.lKLGsIlNpTNpcTIshSLoVscshCIshEusuGsGYlWsLLGVHKpcPhINPEpFPpKhlpKsaFSpEISVTQPKthphsp.sspKNsspsspsuuQNpssos+P.KPc...pllGGss.lpSlIKuHKsGKYalVYSYYRPFsPTusANTKIlpLTVQ	.........spp.tLpssE.CDp.lKLGsIlNpsNpcTIphshsVsplLCIsLEu.sGsGalWsLLGVHKccPhIsPEpFPpKhlpcSaFSp-ISVTpPht.hph..sp.sspcssspptpssspNpssp.+P.psc...pllGGsshlpShIKsHKsGcYaIVYSYYRPFsPTtssNT+IlpLsVp....................................................................	0	1	2	5
+12463	PF12629	Pox_polyA_pol_C		Poxvirus poly(A) polymerase C-terminal domain	Bateman A	agb	Structure	Domain	This domain is found at the C-terminus of the pox virus PolyA polymerase protein [1].	27.00	27.00	48.10	48.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.33	0.71	-4.59	13	66	2009-10-19 14:10:58	2009-10-19 15:10:58	2	2	44	9	0	62	0	197.10	65	42.22	CHANGED	LLsMlKMFSQIDRLEDLscs.EKhplRhuTLLEYsR...hcauIhhsGc...psphshpssh....shspRllTVDs+pY..shsacKChlYLDEss....................LspcIhchs..uD-u.lDFEsV......oNSsaLIcsssh...................YTYFSN....TlLhpscsclH-ISs+uloAHIL...lYplLT+sshtp.sLuDllNSLlshE...KhPlaplIPRDKKsG+HGIIDIEKDIIsH	.LLNMIKMFSQIDRLEDLoKDPEKFsARMAThLEYVR...YTHGIlFDGc...+NNMPMKClI........DcssRIVTVsTKcY...FSFKKCLVYLDENV....................LSSDILDLN..ADousDF.ESV......TNSVYLIHDNIM...................YTYFSN....TILLSDKGKVHEISARGLCAHIL...LYQMLTuG-Y+Q.sLSDLLNShMsR-...KIPIYShsERDKKsGRHGhINIEKDIIl..	0	0	0	0
+12464	PF12630	Pox_polyA_pol_N		Poxvirus poly(A) polymerase N-terminal domain	Bateman A	agb	Structure	Domain	This domain is found at the N-terminus of the pox virus Poly(A) polymerase protein [1]. According to SCOP this domain contains a helix-hairpin-helix motif.	27.00	27.00	38.20	85.80	24.10	23.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.44	0.72	-3.95	13	66	2009-10-19 14:14:05	2009-10-19 15:14:05	2	2	44	9	0	61	0	112.10	65	24.00	CHANGED	MNp........p..hpllcpYLGR.PShsEYahLKpQh+sIp+IhtFNKDlFlu...LlKKNK++FFoDlc..sSsuEIKcRlhpYFoKQcpsp.plG+LhoIIELQolLVooaTclL........GVLTs	........ohsN....IslcIIEsYLGRlPSlNEYHMLKLQsRNIQKIslFNKDIFlS...LVKKNKKRFFSDlD..TSuSEIK-RILSYFSKQTQTY.sIGKLFTIIELQSVLVTTYTDILGVLTI............	0	0	0	0
+12465	PF12631	GTPase_Cys_C		Catalytic cysteine-containing C-terminus of GTPase, MnmE	Coggill P	pcc	Pfam-B_102 (release 24.0)	Family	This short C-terminal region contains the only cysteine present in these proteins. It is proposed that MnmE is a tRNA-modifying enzyme and that Cys-451 functions as a catalytic residue in the modification reaction.	22.00	22.00	22.00	23.30	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.45	0.72	-3.57	534	4286	2009-10-19 15:56:53	2009-10-19 16:56:53	2	10	4170	8	1009	3196	2082	72.50	33	15.93	CHANGED	ttsspsshlsptRHhpsLp.pAhptLp.ps...........hpslp.......tt.....hs...............h-l...hu.-LRtAhcsLucIT..G.c...hs.s.-.-lLspIFSpFC	..............................................................s...t-sshluppRHlptLc.pAtppLppu.............tptlp......ts......hs....................................................................h-L..lu.-L+hAhptLuEIT...............G.-....hs.sD.-LLspIFSpFC...............	0	338	634	843
+12466	PF12632	Vezatin		Mysoin-binding motif of peroxisomes	Coggill P	pcc	Wood V	Family	Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes it binds to class V [2] and class VIIa [3] myosins to guide the organelle through the microtubules [2] and allow pathogens to internalise themselves into host cells [1]. Vezatin is crucial for spermatozoan production [3]. In mouse cells it interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA [4].	22.30	22.30	23.80	23.90	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.72	0.70	-5.30	32	191	2009-10-20 13:22:29	2009-10-20 11:54:41	2	3	153	0	121	198	1	252.80	27	36.68	CHANGED	sshhhlshLlphsphttsshh....h.......hhhlllhlhhslhththhc.....lphh+ppsltplpshlssspshsshhppslhhl..p..El-lhSpuhp.......................t.tpptpspph.tL+ctLppsls.hh.phpputpplh.hhs.........sssLpcYhslYsl...............s..sLt.........................h.p...................pptc-........................t.olptL+hhht.....+hphlRKhhLCpLLolpt......ts.stsshh........................................................capslhptlpsLspslsph	.......................................s...hhlshLlth.sp..hhs..s.sh.hhth......................lllhlhllhhulhhatht+........LphhhpphhsplpshlssupsFsshsppultLI..Q..EsEllSRGap...................uss..shut.....pp.sp.+hltLR+slhpslpthhpshp...uphhhhhhhs...............ssslppYhslh.sl................pphsLs.....................u.pt...hs-...................ppscs.............t.SL.sL+.hLht.....p.chhR+hhL..LLuhss.........sG...sshh...............................................................................chsshhptl+sLp.hhp.........................................................................................................	0	25	53	91
+12467	PF12633	Adenyl_cycl_N		Adenylate cyclase NT domain	Finn RD, Bateman A	agb	Ref [1]	Domain	\N	21.60	21.60	21.60	21.90	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.30	0.71	-4.79	18	1003	2012-10-02 22:47:23	2009-10-20 16:23:27	2	7	911	0	113	583	22	184.90	65	24.20	CHANGED	Mt.clpph+p+lDtLsplRl-RALuuhssphpcVFpLlPLLLHhNHPtLPGYls.ssPpGIspFplo-hQppaLssh........................hphp.....t......hpsspssIhGlYuMGSTuSIuQospSDLDlWVCasspLosc-hpLLppKspLlppWAcpasVElNFaLhcpp+FRpppsus......hstEsCGSuQHhLLLDEFYRSAlRLAGK.LLWh	..........................................................................................M.hYlpTL+QRLDulNQhRl-RALAuMussFQpVasLLPsLLHapH..PLhPGYl-..G.....s.VPp..G.IshasPs-p.QppaLs-L........................t.t.h.s......t......spuchPIsGlYoMGSTSSlG.QSsS.SDLDIWV.CH.Q.S.WL.DuEE.RQLLQRKCSLLE.sWA.A.S.LG..VEV.SFFLIDENRFRHNESGS......LGGEDCGSTQHILLLDEFYRTAVRLAGKRILW.s.................................	0	16	40	81
+12468	PF12634	Inp1		Inheritance of peroxisomes protein 1	Coggill P	pcc	manual	Family	Inp1 is a family of peripheral membrane proteins of peroxisomes. Inp1p binds Pex25p, Pex30p, and Vps1p, all of which are involved in controlling peroxisome division. The levels of Inp1p vary with the cell cycle, and Inp1 acts as a factor that retains peroxisomes in cells and controls peroxisome division [1]. Inp1p promotes the retention of peroxisomes in mother cells and buds of budding yeast by attaching peroxisomes to as-yet-unidentified cortical structures [2].	20.70	20.70	21.80	20.80	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.87	0.71	-4.52	28	115	2009-10-20 15:46:51	2009-10-20 16:46:51	2	2	114	0	83	108	0	140.90	28	25.09	CHANGED	stspcsoLFpasssKIl...........t......................h...hspspo.shpppsppllupGshcIaplpsu...........................pssaLssG...shVaPlL.P+hplhpl...ptpsspFlL.lhsPpp.YW+IElss.....p..--tpllcphcpllsplspYps	........................................................................................sLatasss+ll............php.....t.....u.pss.........hp.s.s..p.pshshpppspphlAhGslcIaplssu............................................ssFLssG...sllaPlL.PKsQsapl.....stpuspFllplhpPp..Ya+IElsst.......sp.E-pphlcphcpVlspllpac..............	1	12	39	68
+12469	PF12635	DUF3780		Protein of unknown function (DUF3780)	Bateman A	agb	Bateman A	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria. Proteins in this family are typically between 189 and 206 amino acids in length. There are two conserved sequence motifs: PEERWWL and GWR. This family is found in a very sporadic set of bacterial species, suggesting that it may have been horizontally transferred. One protein is annotated as plasmid borne.	21.70	21.70	22.30	22.20	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.45	0.71	-4.78	12	34	2009-10-29 09:18:49	2009-10-29 09:18:49	2	2	34	0	15	37	6	187.40	38	93.73	CHANGED	Msp................ptpshGFGhsss.ssHpFhV.IPsu+spsVhlhEpauhpuGpsup.................ss...t.RspLs+ptWptlucslcpcFNpRL+cpphpsuRW.KsGcN.V-.RLLGKELsVLsWAlE.sAss-plPsAlpNWpuL+PEERWWLashTsAtsGtspcst.pGWR+AlRhALs-sP................t...h.s+p.h.............spscppphshhcp	................tttslGFGhsssps.HHFhV.IPp.upss..sVhlhEpashpssppsp..............................................ps..h.+shls+.pWptItstlppcFNtRL+pcshpsu+W..KsGpN...sVc.RLLGKELsVLsWAlE..cs.sscplPlAl+NW.uL+PEERWWLasMTsAuTGts.pDpt.+GWRhALRaALs-sP.................sp....p................p.....................................	1	8	10	13
+12470	PF12636	DUF3781		Protein of unknown function (DUF3781)	Bateman A	agb	Jackhmmer:Q17ZV8	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 82 and 98 amino acids in length. There are two conserved sequence motifs: GKNWY and ITA.	27.00	27.00	28.10	32.00	24.10	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.26	0.72	-4.02	19	84	2009-10-30 16:24:37	2009-10-30 16:24:37	2	6	80	0	15	75	3	72.10	47	72.53	CHANGED	LLpNl-.+lHTT-LGh.RI++NLsLcss-V.l-...aCKpKIhs.ssAhIp++GKNWYsps-s..shlTlNAaSYTIITAH	.....LLpNl-.+LHTT-LGhhRI++NLuL..ssp-V.lp...aCKpKIhs.ssupIpR+GKNWYlps-s..hhITlNAhSYTlITAH.......	0	10	14	14
+12471	PF12637	TSCPD		TSCPD domain	Bateman A	agb	Jackhmmer:Q17ZZ5	Domain	This family of proteins is found in bacteria, archaea and viruses.  The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD after which the domain is named.  Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulfur cluster. This domain is found at the C-terminus of some ribonucleoside-diphosphate reductase enzymes.	21.60	21.60	21.60	22.60	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.07	0.72	-4.04	149	1269	2009-10-30 17:23:21	2009-10-30 16:52:16	2	33	1088	0	416	1079	1406	91.80	27	13.21	CHANGED	acsps.sC....shhlslsh-.t.s...........lhtslshsGGC.suphpulu+Ll.......pGhs...lc-....llcpLcGIpCsspss.....................SCPDtlucALcphh	.................................s..sp...phYlshsth...t..c...G........hElFl.s.htptG....us.tuhhpuhuthlShsLp.....hGss......l-p....hlcphpslchtssGhh.t............t.h.SlhDhlh+tLt...h.....................	0	186	331	383
+12472	PF12638	Staygreen		Staygreen protein	Bateman A	agb	Jackhmmer:Q181L4	Domain	This family of proteins have been implicated in chlorophyll degradation [1,2]. Intriguingly members of this family are also found in non-photosynthetic bacteria.	27.00	27.00	27.60	27.50	23.10	19.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.96	0.71	-4.67	21	155	2009-11-02 14:20:47	2009-11-02 14:20:47	2	3	98	0	61	150	2	143.00	41	65.43	CHANGED	spFsssKLpVpFhsstspstPh.....hPRpYTLTHsDhTucLhLsIupshshs.pl....sch.RDEVlAEW.pc.psp..hsL+VasaVS.GuphhhshuAp.RahIFp+ELPLlLcAlhaGDpsLFppaPcL.sA.VaVaFcSs..hP.....pa............s+hEsWGslp-hu	.........s.hFpssKLpV.Fhs..sspp..ppPh................hsRpYTLTHSDhTucLhLsIupshshs.pl.....sphtRDEVluEW.+csp.......sp........hsL+Vasalu.GsphhhchssthRahIFp+ELPlsLcAlhaGDpshFspaP-Ltpu.laVaFpSs..hs.ca...................N+lEsWGslp-h.s...................	0	18	48	54
+12473	PF12639	Colicin-DNase	Colicin-DNAse;	DNase/tRNase domain of colicin-like bacteriocin	Coggill P	pcc	pdb_1bxi	Domain	Colicin-like bacteriocins are complex structures with an N-terminal beta-barrel translocation domain (Pfam:PF09000), a long double-alpha-helical receptor-binding domain (Pfam:PF11570) and this C-terminal RNAse/DNase domain with endonuclease activity. Their competitor bacteriocidal action is by a process that involves binding to a surface receptor, entering the cell, and, finally, killing it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3 reveals a Y-shaped molecule with the receptor binding domain forming a 100 Angstrom long stalk and the two globular heads of the translocation domain and this catalytic domain comprising the two arms [2].	21.50	21.50	21.60	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.87	0.72	-3.81	57	525	2012-10-05 18:28:12	2009-11-02 18:40:55	2	27	407	56	43	461	2	108.50	29	25.68	CHANGED	sshspsG................a.ths...sthss.ls.phtcpLp.....ucchspFcphpcthhpsl...............tpsspltppFstpphpth.psthsP...............ppaphHHppp..tG.......shpllsschHtp.....hHpG	...............................................................................................................................................................................................................c..pphsphRKphhcsV...............ucss-huup.....F...s....s.....c....s....lt..ph.+p...GpsP...........................................................hsYslHH+hslpsGGss.ch-NlhLlpsc.Hcc........................	0	5	14	22
+12474	PF12640	UPF0489		UPF0489 domain	Bateman A	agb	Jackhmmer:Q181H4	Domain	This family is probably an enzyme which is related to the Arginase family.	27.00	27.00	28.50	27.80	25.00	23.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.29	0.71	-4.04	34	190	2012-10-01 22:40:15	2009-11-03 13:56:57	2	4	158	0	102	176	2	174.40	25	49.67	CHANGED	lall-sHccshhhWhctlppt.h...pshpllHlDpHsDhhhsh...................phshphshpt......t......phshctlsh.-saI..hsAlhsuhlsclhhlppshs................................................hh.t...h.....t....hpphptht.htshshpp.hhpt..sh...........................................................................p.ppsalLDIDLDaF	...................lalV-sHpcsl..........ahhcsltppcls..pshph..lHhDuHsDhhlPh......................................................shssssshsc...................cthhspLs.I..-NaI....hPulauGah.s.clhalcssau...............................................p..hthst...hhhspt.h.s........ttp.......hpp.h.hp.hps....h.hps......t................................................................................................................................................................................................................................s..psalLDlDLDaF..............................................................	0	38	53	78
+12475	PF12641	Flavodoxin_3		Flavodoxin domain	Bateman A	agb	Jackhmmer:Q180M7	Domain	This family represents a flavodoxin domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.82	0.71	-4.81	44	396	2012-10-03 05:08:30	2009-11-03 16:27:47	2	6	311	0	78	1420	207	144.70	24	88.08	CHANGED	hllYSShTGNT+plAcuItpslss..pshhshpcsps.....hsph..DllhlGFWsDKGssspchtcalps.L+sK+lhlFGThGhsssscahpphlppspphlsps.NpllGpFhCQGKhs.plpc+acph....tpstpptthsphlppa-pAhsHPDpsDlppucphsc	..........................llY.s.S.h.o..GNT+plAcsI....tctlss...........tph.h.....s.h..p..ps.ss.....................hpsa....D.h.l.hlG...h......W......s.........D..c..G......p......s......s...t..c.........h......p....c...a....l.......p.....p.....l......c.....s.....K....p....l.....h..lFu...T..h..G....s..t........s..p..p..a.h...p..p...h...h.p.p.h....t....p.h..hs...pt...sphh...s...th...hs..p......G...t.h.s..t........h.thh.t.......................t.h..s..cP.s..ch..h.....t.........................................................................................................	0	30	61	71
+12476	PF12642	TpcC		Conjugative transposon protein TcpC	Bateman A	agb	Jackhmmer:Q180I0	Family	This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologues from Tn916, Tn5397, and CW459tet [1].\	 This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.	27.00	27.00	28.00	27.80	26.90	26.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.47	0.70	-4.81	47	781	2009-11-04 11:35:59	2009-11-04 11:35:59	2	2	512	6	62	457	7	223.70	29	72.09	CHANGED	saspsFsppYho....tspcsh-pRtppLp.tYlspphp..ststhpt.......sppltssplhslcpp.........cpthhlphpVphphs..............ptcptpp....................pthsVPVth....pssshslsu.Pshss.hsppushpspttpscsshst.tt......pclpcFLpsFFchYssuspp-lshhhpsss......slsssh...th........tclsssphhpppsshpsslt............Vpah-pt.....optphsppasLpLp.cp....sspahlpc	..............................................................................FscsFscsYao..hppspcsh-pRhppLp.tYLsp-hpshs.cts+pt......suslpshplhslcpp..............cspaslpapVc.pls.......................pscptpslp............................ssapVslhh.........tssshlllp.Pshss..hPp.p..u..s.....hpsK.th.-scsss-stss.........pclspFLpsFFchYsoust..p-.LuYasssshh.....slstph....ha...........pclsss.h..hhcc.....s.sps.hlsls............VpahDpp...............oc.sTpsp.pasLsLp..Kp.....sssWhIh...................	0	30	44	53
+12477	PF12643	MazG-like		MazG-like family	Bateman A	agb	Jackhmmer:Q181R3	Domain	This family of short proteins are distantly related to the MazG enzyme. This suggests that these proteins are enzymes that catalyse a related reaction.	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.18	0.72	-4.06	25	305	2012-10-01 21:36:44	2009-11-04 14:23:11	2	3	298	0	61	203	5	93.40	35	86.29	CHANGED	Ih+NlKhIEtLKuELLs......pluclF+hLs+Gup...p-uIl-sluslIllsYlLucRLGhsapclDcslccKL+luIhEccc.lEK.ht-LScLtp+L......cc+c	..........................................tRNh+.hcs.Ks.hlu......-LhEL...Fphhosp.p......s...tp......t..E..cIt-ELADllIYsYhlADpLGhD....lDEhlccKLccs.t.h.chs...Ec..................................	0	25	45	57
+12478	PF12644	DUF3782		Protein of unknown function (DUF3782)	Bateman A	agb	Bateman A	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 91 and 186 amino acids in length.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.06	0.72	-4.18	54	159	2009-11-04 17:31:12	2009-11-04 17:31:12	2	7	87	0	50	145	10	79.80	20	52.38	CHANGED	pchtchpc...........................................chtphpcclpph................................................................hsccphchlp........................chhstlstthshtsEpsa+pGhp-slphhtt	....................................................................................................................................................................th.c...............................phhthpccLpph...................................................................hocEs....hchlp..............................phhstlutths..sEtta+.Ghpthlp..........................................................................................	0	17	23	28
+12479	PF12645	HTH_16		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q180H2	Domain	This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.	21.60	21.60	21.60	21.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.88	0.72	-4.04	52	618	2012-10-04 14:01:12	2009-11-05 10:29:19	2	3	295	0	35	325	44	61.90	36	77.88	CHANGED	aplIht.AspGDspAlpplLpHYcuYIsphsh+.hhc.chGpshhtlD--l+pclct+Llps.llpFc	........a.lIhp.ApcGDspAlpplLp+YcuYIs+hshR.hhs.-hGphphhVDEph+pclcp+LIpt.ILpFc........................	0	17	28	28
+12480	PF12646	DUF3783		Domain of unknown function (DUF3783)	Bateman A	agb	Jackhmmer:Q180F4	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.	27.00	27.00	30.80	30.00	25.30	22.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.59	0.72	-4.22	69	284	2009-11-05 10:33:20	2009-11-05 10:33:20	2	1	262	0	72	251	7	58.20	26	39.88	CHANGED	pchllhssh.ssp..clcphlpth+ct....th..phslhAslT.sNhpWshppLh.cEltcE+chhp	...chllhssh.ssp...clpthlpsh+ct....tl...phslhAslT.sshsWshppLl.cElhcE+chhp...	0	35	57	68
+12481	PF12647	RNHCP		RNHCP domain	Bateman A	agb	Jackhmmer:	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 143 amino acids in length. There is a conserved RNHCP sequence motif.	24.00	24.00	25.00	37.20	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.97	0.72	-10.73	0.72	-4.16	27	115	2009-11-05 10:59:04	2009-11-05 10:59:04	2	2	95	0	46	118	8	87.30	46	61.11	CHANGED	spsssFpChtCGhtVsstusGos+RNHCPsCLpShHlD.phPGDRAus.CtGhMcPlulhsRpsG-WsllHRCppCGcLspN.....RluuDDN.hhLhp	..s.tpsFhChtCGh.V.s.usGotaRNHCPpCLhShHVD...PGDRuus.CtGhM-PlulhV+psG-WhllHRCppCGpLssN......RlAuDDN.hhLh.................	0	20	36	44
+12482	PF12648	TcpE		TcpE family	Bateman A	agb	Jackhmmer:Q180I5	Domain	This family of proteins includes TcpE a conjugative transposon membrane protein.This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 168 amino acids in length.	22.20	22.20	22.90	22.50	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.39	0.72	-3.90	31	672	2009-11-05 14:27:45	2009-11-05 14:27:45	2	2	429	0	44	272	10	98.40	39	70.53	CHANGED	sYsphaphphhlYpItc.hpLPh.s..lshpph....shFllhhlslhlhhtlhs.........htpshhhhhh.hlPhhlshhhsphch-GKphhtalhshlpahhch+hpppthhht	.............sYsphaph.hVlYtIsD..hpLPh.s......lshsph....saFll..h.hhl.hlh.hpl.s.s............hhpGsh.L.pYh.slPsslTaahopKpFDGKKsasFL+uhls.Yhhc.Klshsst...p........	0	23	33	38
+12484	PF12650	DUF3784		Domain of unknown function (DUF3784)	Bateman A	agb	Jackhmmer:Q180M1	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 96 and 110 amino acids in length.	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.35	0.72	-4.05	48	316	2012-10-01 21:33:42	2009-11-06 14:28:11	2	2	238	0	39	256	75	92.90	24	80.06	CHANGED	hhlull....hhllulh..lhpsKushLloGaNohsccE+cchDpppls+hhGphhhhhul..lhllsul....hthhhsph........hslhhhllhllhhhhhlhhsschp	...................hlull..hhhluhh.......ltst+tshLluGaN....cE+chhDcp+Ls..+hhGhhhh.lhul..lhhltul....hthhhsph............hhhhhh.hlhllshllhhhhss...h..........................	0	18	31	33
+12485	PF12651	RHH_3		Ribbon-helix-helix domain	Bateman A	agb	Jackhmmer:Q17ZT4	Domain	This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.70	0.72	-4.23	28	354	2012-10-02 18:44:02	2009-11-06 14:36:52	2	4	316	0	62	379	17	42.50	33	41.58	CHANGED	pRpphosolsp-Lhp+LcpLSccTpIPhS+LlDEAl-hLLc+Yc	..........hpphohplspElhp+LDslScsp.u.l.sKScllcEAlptaLpph...........	0	25	39	51
+12486	PF12652	CotJB		CotJB protein	Bateman A	agb	Jackhmmer:Q181Y6	Domain	CotJ is a sigma E-controlled operon involved in the spore coat of Bacillus subtilis [1]. This protein has been identified as a spore coat protein [2].	29.00	29.00	29.00	31.20	28.80	28.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.67	0.72	-3.90	71	380	2009-11-09 12:44:13	2009-11-09 12:44:13	2	2	344	0	68	260	3	77.60	41	85.47	CHANGED	cppLLppIptlsFull-lsLYLDTHPsDppAlp.apphspptpphhcpYpppaGPLs.thsss..st.............p.W.sWlpsPWP.....W-	...h.hpLLcplppl-FsllELsLYLDTHPcDppAlppaNphupppppLpppaEppYGPLppaGs.u...s.p.............ssW.pWscsPWPWp.......	0	36	54	59
+12487	PF12653	DUF3785		Protein of unknown function (DUF3785)	Bateman A	agb	Jackhmmer:Q181X2	Domain	This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. These proteins share two CXXC motifs suggesting these are zinc binding proteins. This protein is found in clostridia in an operon with three signalling proteins, suggesting this protein may be a DNA-binding transcription regulator downstream of an as yet unknown signalling pathway (Bateman A pers obs).	27.00	27.00	186.90	186.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.89	0.71	-4.32	8	29	2009-11-09 15:44:53	2009-11-09 15:44:53	2	1	29	0	4	16	0	136.60	56	100.00	CHANGED	M-.YKFsYD-KEYlLsc-NCsshFND...EpcElcGlSl-cILchLspuEEVsFupEYYp-sCs.ChsGhEEKpKhFsFLEYHFYIYTK-sKYVISsIsKEY-spSFNKLhRAsKVDcSYIVSllVCtNCGsYsIpIEpCpV	..h..aKFsaD-KEYhLsE-ph.hhFN-...t.t-VcGhsI-Klh-ILNpuEtVsFuptYYpssC..ChtGlEEKKK.FPFLEaaFaIYoKsGcaVISNIpK-YcGLSaNKLhRspKVDcSYlVslsVCcNCGsasVplEphpV.	0	2	4	4
+12488	PF12654	DUF3786		Domain of unknown function (DUF3786)	Assefa S, Coggill P, Bateman A	agb	Pfam-B_16102 (release 23.0) 	Domain	This presumed domain is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 201 and 257 amino acids in length. Some proteins also contains an iron-sulfur cluster.	27.00	27.00	27.70	50.20	22.80	20.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.88	0.71	-5.01	53	182	2009-11-09 17:15:17	2009-11-09 17:15:17	2	2	71	0	79	186	21	177.60	23	80.83	CHANGED	hDhpplupphGs.h.t.ptpt...lpl.hhGpsaplshsshthsstcsssh..........hpllllcYLhpus.sts.ss.cWlsa+-lssGt.ah..ssFppc.s.psLschassp.hcphppssctLGGp.hstu......DhuhhhpslP+lPlhllhWpu..D--FPupuslLFDpssspaL.ssEslhsluthlsphL	....................h.s.tplupphusth...p.pt...htlpahuppatlshssspl...hstpssth...................................hplllLpYLhpup..sh...s..ss.caloa+El.s.s.G.thah..ssFppp.shpsLtchFusp.hcth.ppsspp...LGGp.hshu......Dhuh..hhpshPclPltllhWpu..D-EFPususlLFDssssphL.ssEslhslushlsth....................................	0	61	79	79
+12489	PF12655	DUF3787		Domain of unknown function (DUF3787)	Bateman A	agb	Jackhmmer:Q185C1	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in Clostridia. Proteins in this family are approximately 60 amino acids in length. There is a conserved TAAW sequence motif that may be functionally important.	20.70	20.70	21.80	23.00	20.00	18.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.57	0.72	-4.24	14	76	2009-11-11 17:47:45	2009-11-11 17:47:45	2	1	75	0	24	52	0	51.40	47	87.27	CHANGED	pcpKcphhshPlEpHsTAAW.ANIcchKshSpVsIPoEppVcNAK-WVDsNpK	.......................pppKcphhthPIEpHcTAAW.ANIpphKPpSsVsIPSE.pVpNAKEWVDsNpK....	0	15	21	23
+12490	PF12656	G-patch_2		DExH-box splicing factor binding site	Wood V, Coggill P	pcc	Pfam-B_900 (release 24.0)	Domain	Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2 [1]. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2 [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.93	0.72	-4.13	74	304	2012-10-01 21:03:39	2009-11-12 14:11:33	2	12	256	0	228	1568	9	76.80	33	18.52	CHANGED	tp.spppthcpclsstP-pssh-..-YcplPVEpFGtA..hLRGMGWc......tupshu+sptt.................ht.ppRss.tLGLGAcshtsp	............................................ht.....tt.p.chttt...s.-pssh-........-Y.c..s.....lP..V.......E......p..F.......GhA...hLRGMGWc......tGpshG+.s.t.tt..............sts.h...s.phRPt..tLGLGAc.h..s....................................	0	78	129	190
+12491	PF12657	TFIIIC_delta		Transcription factor IIIC subunit delta N-term	Coggill P	pcc	Pfam-B_74169	Domain	In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts [1]. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8 [2].	27.00	27.00	27.10	27.40	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.30	0.71	-4.55	35	186	2009-11-13 16:10:32	2009-11-13 16:10:32	2	15	151	0	131	188	0	162.20	21	22.39	CHANGED	pshPoshssluWSsDGclAlusuctVpl.L...........sPp.......................pt..ttspshsssshpaphsphcsshh.s.pphP.................thhspshsh.hs.t........t-.psu..........plhuluWSP.GLup...p.......RClLAVLToshtLolapsstt...pucWsclsslschLt.....................................t..t....tts.hh.........pc.plpuhsWs	........................................................................p...ssh.pslsWSpDs.pluVsssc.ltlL.............sPt..............................................................t.t..ts.t.....t........ththh...psp.h..s....st.s.......................................th..t.h.s................t.t...................thhthuWSP.G.hsss..t.........................+ClLAsLTssspLslats.t....p.pWh..pl.sslschhh........................................t....st.............p....t......thta................................................................	0	30	65	100
+12492	PF12658	Ten1		Telomere capping, CST complex subunit	Coggill P	pcc	Wood V	Domain	Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex [1]. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast.  Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [2]. Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms [4].	21.60	21.60	21.70	21.60	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.58	0.71	-4.36	27	90	2012-10-03 20:18:03	2009-11-13 17:26:38	2	2	88	4	62	79	0	132.90	26	80.45	CHANGED	Mo....sP.ssphh..............Fh.pphsshstsp+lRhLu.................sVppYshssG...pLhL-+..shst.......t.t.ss.....lsVDlshlLss.lpsc.................clplGsWlNllGYlctpt.............................................................hVcAlhlhsusulplscY..cclLp	.............................Mo....sPhs.p.h..............hhpp.sthtsup+lRhLu.................CVssYshtsG...pLhLc+.......shsh..........................ptt.sp.....................spVDlpllLps..lpsp............................plplGsWlNllGYlpttt.........................................................tpsshlpAlhlhssushcltcY.pchl.......................	0	9	30	49
+12493	PF12659	Stn1_C		Telomere capping C-terminal wHTH	Coggill P	pcc	Wood V	Domain	This domain consists of tandem winged helix-turn-helix motifs. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex [1]. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [2].	25.00	25.00	26.40	49.70	21.90	19.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.61	0.71	-4.31	10	23	2009-11-13 17:32:48	2009-11-13 17:32:48	2	1	23	2	15	23	0	124.20	41	26.69	CHANGED	hKuhDslctcsap-lLspLsppGLIslcupop..lcLhsLKsla-Ysp+RIusLlKLQshTGslchs+Vpp..+LphPhhopphIVDlaKEsL++hptt.splLpsWWI-hcs+sth.......hlHFpYspup	............hKShDsLcpEsFcDlls+LlspGLIsLcs+os..hDLhPLKsLa-YspKRIslLhKLQChTGTlplo+Vpc..KLclPhlTspuIVDlFKEsLK+tpKphPplLKsWWIDLcscsth.......llHLEYsts.h..	0	2	7	13
+12494	PF12660	zf-TFIIIC		Putative zinc-finger of transcription factor IIIC complex	Coggill P	pcc	Maraia R, Wood V	Domain	This zinc-finger domain is at the very C-terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions [1].	22.10	22.10	22.50	22.70	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-11.02	0.72	-4.09	16	171	2009-11-13 18:18:58	2009-11-13 18:18:58	2	11	153	2	124	170	0	90.00	25	12.66	CHANGED	+shpshps.u........EpCslC......cuslsasssppApCssGHhWhRCuLTFhulQsssh.+hCslCs.sthhstshttspp.....................hchLhpshssCh..aCuuchh	..........................hsp..................EpCshC..........pt...l..s.hps.hcp......uh.CssGHh.ahRCslThhslps.th..+hC.lss.phshp..t....ts....t..............................................................................hphL...p.t....C.aCss...h............................................	0	30	57	92
+12496	PF12661	hEGF		Human growth factor-like EGF	Wouters M, Coggill P	pcc	Wouters M	Domain	hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan.  The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC.  These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin.  Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.	18.00	13.60	18.00	13.60	17.90	13.50	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.16	0.73	-5.96	0.73	-3.51	521	6130	2012-10-03 09:47:55	2009-11-16 12:53:17	2	1671	227	11	3408	13199	236	13.00	50	2.13	CHANGED	pCpCssGaoGspC	......pChCssGaoGtpC..	0	1352	1597	2396
+12497	PF12662	cEGF		Complement Clr-like EGF-like	Wouters M, Coggill P	pcc	Wouters M	Domain	cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin.  Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.20	0.72	-4.29	733	2407	2012-10-03 09:47:55	2009-11-16 13:04:43	2	940	145	0	1458	7661	32	23.80	49	2.31	CHANGED	SapC..s...C..sGYp...........h.........s.-u.ps.........CpDIDE	......SapC.....p.....C...sGap...........Ls.........s.DG.+s.........C.p.DIDE........	0	669	767	1040
+12498	PF12663	DUF3788		Protein of unknown function (DUF3788)	Bateman A	agb	Jackhmmer:Q189D9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 137 and 149 amino acids in length. This family may be distantly related to RelE proteins.	25.00	25.00	27.40	27.10	23.30	21.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.33	0.71	-4.48	39	174	2009-11-19 14:09:27	2009-11-19 14:09:27	2	5	124	0	34	153	9	124.80	26	87.02	CHANGED	sppphPo.cplpsalGpsh...apclpphlpppYt..hph-ashsutphGWslKa+..KtsKsLCslasccshFsshlhlGp+ctpch-thh.shostlpchacpspshss.G+Wlhl-lpspshlp.DlhcLltlKt	...............pphPs.cpltthlup.sh...appLpphlpppYs...phcashsutphGWshK..Y+.........KtuKsLCslasccshFsshlhlGccctt..ph-thh.phos.spclaccspshss..G+..WLhhclpspshhp.DlhcLlpl+p.........	0	18	30	32
+12499	PF12664	DUF3789		Protein of unknown function (DUF3789)	Bateman A	agb	Jackhmmer:Q18DB3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two completely conserved residues (V and C) that may be functionally important.	22.00	22.00	23.10	22.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.34	0.72	-4.63	11	148	2009-11-19 14:19:49	2009-11-19 14:19:49	2	1	103	0	8	89	6	33.20	46	71.96	CHANGED	pllpDhLLsohGsslGVslMCllpsGKtADccMc	......llKDhLLs.hGuhlGVslMClhpsuptADptMc......	0	4	7	7
+12501	PF12666	PrgI		PrgI family protein	Bateman A	agb	Jackhmmer:Q187G3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 116 and 146 amino acids in length. This protein is found in an operon that is part of a Type IV secretion system.	27.00	27.00	27.30	27.20	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.04	0.72	-3.84	74	644	2009-11-20 16:12:33	2009-11-20 16:12:33	2	2	377	0	81	480	60	93.20	27	64.99	CHANGED	pVPKDls+.hcsKlhhsL.ThRQLlshuhushlGlshahhh.+thl........u.........sshushlhlhshlP....hhhhuhachcG.hshEchltthlchc.lps+htsapo	..........VsKDls+.hcpKlhhsL.TpRQllhhssushl.u.ls.lahhh...pthh.................s.......sshuhhh...hl.hsslP....hhhhuhach..cG..hs....hEchlthhl+hc..hpscpRsat.................	0	46	65	75
+12502	PF12667	NigD		NigD-like protein	Bateman A	agb	JCSG target Q5LAY5_BACFN	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroides species. Proteins in this family are typically between 234 and 260 amino acids in length. These proteins possess an N-terminal lipoprotein attachment site. The family includes NigD a protein found in the Nig operon that encodes a bacteriocin called nigrescin. It has been suggested that NigD may be the immunity protein for nigrescin (NigC) because it is directly downstream [1].	21.00	21.00	23.50	23.20	18.80	18.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.50	0.71	-4.51	55	331	2009-11-21 13:39:49	2009-11-21 13:39:49	2	1	107	19	39	282	1	190.80	20	78.62	CHANGED	hsTspssss...t.........htsDc..GsplhPsssss.........hssssupRshss..a....p.htpt.......sshshslplhtlpsllopsst.......hssp...p.p.thusDPltlhsh........Wh...s..ttYLslhaphphs..........sptppHhhsLlhsp.............tt.tsssshlpLpLRHs.....s.u..Ds.psthtp..u...........hlSasL.spl.sppttt.....ptlcl+hpsht.suctph.p	...............................................................s....ss...t.....hhthDc.us..pl..hPsssph............hpsspspRsls...a....s.hppt..........sshshslpl.ptlpsllotsht..........t.hssc...p.c.thusDPlplhsh...............Wl.....s..ssYLslhaphphs..........pptp+..HhlsLltsp.................t..spsshlpLpL+Hs......stu.....Ds.pshhtp..u...............hlSasL.spl..sptttt.....pslplphpsht.suc.p..th.............................	0	11	33	39
+12503	PF12668	DUF3791		Protein of unknown function (DUF3791)	Bateman A	agb	Jackhmmer:Q184Z5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 71 and 125 amino acids in length.	21.90	21.90	22.80	22.10	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.87	0.72	-4.36	45	302	2009-11-21 15:27:16	2009-11-21 15:27:16	2	4	144	0	37	238	2	61.40	24	67.45	CHANGED	lpFslh.....sIEshAcchshssp-shphhp.chsllc.aIhppY-sLHTput-all-Dlhchlcpps	................tahhh.....hIcphAcchslsspcshphhp.chs..llp.alhppY-sLHTpupcall--lhphlppp........	0	18	33	37
+12504	PF12669	P12		Virus attachment protein p12 family	Bateman A	agb	Jackhmmer:Q18C01	Family	This family of proteins are related to Virus attachment protein p12 from the African swine fever virus. The family appears to contain an N-terminal signal peptide followed by a short cysteine rich region. The cysteine rich region is extremely variable and it is possible that only the N-terminal region is homologous.	33.50	33.50	33.50	33.50	33.30	33.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.85	0.72	-3.77	134	610	2009-11-21 15:48:40	2009-11-21 15:48:40	2	2	570	0	65	310	5	50.80	31	79.85	CHANGED	slllslllhshsh.hh...l.hphh.+p.....p+p..G...........s.sC...u..C.........tssCtstt.......................................................pppc	......sIlI.shl.Ihuhsh..as..l.h+hh.K+..sKp...G........pCusCthsps.C............tCssp......................................pp......................	0	25	52	58
+12505	PF12670	DUF3792		Protein of unknown function (DUF3792)	Bateman A	agb	Jackhmmer:Q183N7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. These proteins are integral membrane proteins.	27.00	27.00	27.90	27.70	26.30	26.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.57	0.71	-4.23	64	372	2009-11-21 16:02:30	2009-11-21 16:02:30	2	1	364	0	85	268	3	115.70	27	90.89	CHANGED	sttphtsllpGllhuhhlohlhhllhulllhhss....lsEphhshhhhhlhhloshhGGhhuu++spp+GalhGhhsGllYhlllhlluhlhhss.hhs.hphhhphlhshsuGslGGhlG	........p..hspslhhGllhshllshlh.hlhu.LlLpaos....lsEsslshhlhllsllShhhuGhhuG++sppKGWlhGhhsGlhahlllhLlshlshsp.shs.sptllhhlhhhsuusLGGllG...................	0	42	70	76
+12506	PF12671	Amidase_6		Putative amidase domain	Bateman A	agb	Jackhmmer:Q18BM0	Domain	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.50	0.71	-4.18	83	491	2012-10-10 12:56:15	2009-11-21 16:27:14	2	11	364	0	128	483	20	158.20	30	49.09	CHANGED	tYspttAlp....YAc+assst.................Nss.......YtsF.........uuD...................CTNFlSQsL....puGGh...................................W...................ttss..........Ws.......supshhpYltps.thstthuttshpth.....................GDllpachs.uss.............................sHsslVoshsspshs........llssHTss....phphshs......hhtstphpathh	.................................................................YsRhpAVp....YAc+.ahsst....................................Nst.......YpsF................ssD...............................CTNFlSQsL.....cuGu.h.shsst...................................................W.............ppsthoh............u....Ws.......sA....cuhh.Yl...tss..tps..t...h.ht.tt..sht.p....t...................GDlItY-hp.scs.......th............................sHoslVsuh-spuhs...................LVssHoss......phph.as.....sh.p.ph.....h..........................................	0	61	107	112
+12507	PF12672	DUF3793		Protein of unknown function (DUF3793)	Bateman A	agb	Jackhmmer:Q18C06	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 211 amino acids in length. There are two conserved sequence motifs: PHE and LGYP.	22.80	22.80	39.80	39.30	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.12	0.71	-4.69	77	325	2009-11-21 16:43:30	2009-11-21 16:43:30	2	2	302	0	75	276	6	175.40	30	88.86	CHANGED	lshpC...APsLuGlKsusLhshs.................htstcplhphhp.hst.h...spslphhhLp..pspsphllhlY+pptLcphLpcppspphLpph..GY....pstslpphLppLppRh......ppst...............................FPHEIGlFLGYPlcDVtGFIppsGpshhhsGhWKVYss.pcuhphFppacps+pthhph.htpG.pslpplsss	........hhhpsAPsLsGlKsusLlshs.................hp.ptppl.t...phhp.apptht....tpslphhhLp..ps..ppphllhlY+cctLpphLpppcsppaLpph..GY......pstslpphLppLppRh..........ppp.p........................FPHEIGlFLGYPlcDVtGFIpppGpshhh.sGhWKVYss.pcApchFppYcps+phhhph.htpG.hsltplh..s..........	0	43	67	71
+12508	PF12673	DUF3794		Domain of unknown function (DUF3794)	Bateman A	agb	Jackhmmer:Q185X2	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF01476.	21.70	21.70	21.70	22.00	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.91	0.72	-3.83	173	709	2009-11-22 14:22:34	2009-11-22 14:22:34	2	10	223	0	199	603	18	88.90	18	45.01	CHANGED	sclt.cIlpspsp.lp..lpch.cl....hps..................................+lhlcGhlphpllYl................upcs....pp.......lpshp.tplsF..sphl-l.tusptsh.psp..lpspl-pl..ssslhss.c	................................................................plt.pllp.spsp.lp....lpch..cl......hps.............................................................KlhlcGhlphpll..Yh........................up-s..........pt...............lpshp..tplsFsphl-l...tusppsh..tsp.....hphp.lcp.h..phph....t..............................	0	122	177	188
+12509	PF12674	Zn_ribbon_2		Putative zinc ribbon domain	Bateman A	agb	Jackhmmer:Q18AK6	Domain	This domain appears to be a zinc binding DNA-binding domain.	21.30	21.30	22.00	22.00	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.36	0.72	-3.64	52	343	2009-11-22 14:37:54	2009-11-22 14:37:54	2	16	275	0	77	278	17	80.40	35	52.03	CHANGED	paCQSCGMPlspss...hGoptDGopsc-YCtYCYpcGpFst.phoh-EMI-hss.ahsctst.....hs.-pA+phhpphhPpLKRW+	.........aCQSCGMPhspss...hGoptDGopsc-YCtYCYcsGtFhp.phoh.-EMI-hsst..ahschst.....hst-pA+phhpphlPpLKRW+..................	0	35	59	70
+12510	PF12675	DUF3795		Protein of unknown function (DUF3795)	Bateman A	agb	Jackhmmer:Q186T2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.	22.60	22.60	23.90	23.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.92	0.72	-11.75	0.72	-3.80	72	322	2009-11-22 14:49:21	2009-11-22 14:49:21	2	10	173	0	78	292	7	73.50	32	51.97	CHANGED	hhuhCGlsCstCstahtsp...............................................Cs.GCtstpt.........htsttCp..ltpC..stc+.slspCucCsc..a.P.Cphhpp	...............huhCGlsCs.tC.ta.ttt.................................................Cs.GCtstph..........tsppCp..l+pC..sp..p.K..sl..saCscCsc.a.P...Cchh.t...................	0	46	75	78
+12511	PF12676	DUF3796		Protein of unknown function (DUF3796)	Bateman A	agb	Jackhmmer:Q185I0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	23.00	23.00	23.00	23.70	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.93	0.71	-3.88	13	204	2009-11-22 16:47:27	2009-11-22 16:47:27	2	1	179	0	17	150	2	106.10	38	77.59	CHANGED	ps+luYL.GFlGFlGF...LG.h.FhsppshFs.hhaFsFFsFFsa...uKl...lsDELFhpcV+tAsopAFhVullhssIlllhl...hlhcNlcl....Iclhl....sIshslsLsTFllsLhla-hppcc.hpD.......pp	...............s...hhhh.GFlGFhGF...LG...a..tt..hh...hFsFFuFFo.a......+pV.........ptDEhF.p.lsKu..sp.uFllsLhshhIlhhI.....hlhss.sL.......phpI....slhhusLIhsFuhshhha-+.........s..................................	0	6	10	12
+12512	PF12677	DUF3797		Domain of unknown function (DUF3797)	Bateman A	agb	Jackhmmer:Q18AB4	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif.	21.20	21.20	21.20	23.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.52	0.72	-4.34	9	99	2009-11-23 09:31:14	2009-11-23 09:31:14	2	2	89	0	3	54	0	53.50	77	43.88	CHANGED	M..pshcslpLhpK...YspCPpCGN-plGNGEGsL...l-DDpFKRTCKCGapIc	....MDLIIQTFPLDGKTLYYVQCPVCKNNRILNSGANVSRIISDDTFRKLCGCTCDVK.	0	1	2	2
+12513	PF12678	zf-rbx1		RING-H2 zinc finger	Coggill P	pcc	Wood V	Family	There are 8 cysteine/ histidine residues which are proposed to be the conserved residues involved in zinc binding. The protein, of which this domain is the conserved region, participates in diverse functions relevant to chromosome metabolism and cell cycle control [1].	30.60	29.80	30.60	29.80	30.50	29.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.22	0.72	-3.87	110	903	2012-10-03 15:03:13	2009-11-23 17:28:56	2	21	332	18	628	6919	344	76.70	40	28.82	CHANGED	+hplp.....c...apuVuhW.p.....Wshs....................-..........s..CuICRsph..ssC.....pCphss.................--...Csl..sh...Gt.CsHsFHhHCI..........pcWL..c..pps.......hCPlCp	.........................................................................................htl+.c.WsuVuhW..s....WDl..........................................s.D..........s.....C.AICRscl...h-..hC...l...cC.pusptt............................................................t--....Csl...........sa...G...C.....s............H.s......FHh.cC.l..........ppWL....+....ppp..........sCPLsp...............................................	0	233	348	516
+12514	PF12679	ABC2_membrane_2		ABC-2 family transporter protein	Bateman A	agb	Jackhmmer:Q189I9	Domain	This family is related to the ABC-2 membrane transporter family [1].	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.86	0.70	-5.54	35	2420	2012-10-03 10:13:34	2009-11-24 09:49:33	2	14	1493	0	891	9805	1242	277.90	14	89.44	CHANGED	hslhcpEapchl+s+phhllsllhhll.....................................hhhshhsphssthhsshtsstpshssh.hh.........................................................................................................hhthllslh........uhlhusshlutEhcpGTlchLLupPloRtpllluKhluthsh....lllshlluhll................................shshhhhhusshshtshhhhhhhshhhhhhh.......hululhlS.slh+..osstAhssululhhhhtllhshhshh......l..h..........................................................h.hl.Ptshhphhhpthhtst................................................................................h..ht.hlhhllhhllhlsluh....hhFp+cDl	.............................................................................................................................................................................................................................................................................h..lhtpEhh.p.h..h...p...p...h...h..h......h....h..h.h....h...l.h.hhh............................................................................................................hh.h.h..h....h.......t..h.........s............h...............t....................t......h...........t....h................h....h............................................................................................................................................................................................................................................................................................................................hhh.h.l..h..s..l.h............s.h..h...l..u.......h.....s....h.....l......u......t....E....h..c.p..G.T.lc....h..L....L.s.p.P.l.oR.s..pl.lh...u....K....h..luh..h..h.h...............hh..l.s.h..l.h..u..hhh...............................................................s.h.h...h....h....h......h.......h....s.....s........s.......h.......s......h.....h......t....h......h....h.......h.......h......h....h...h....h...h...h....h..hhh..............h...h.u....l...u...h.....h..l.S...s..h....s..p......p....p....t..h....A..h..s...h....u....l..s.l.....h....h....h......h......h.....l...l..h..s..h....h...h....h.h..........h.......h.............................................................................................................................................................h...h...........h...s....h....h...p..h....h............t...h...h..t.s...............................................................................................................h...........h....h.h....h....h...h.h..h....h....l...h.h.h.lsh.......hhFt+t..............................................................................................................................................................................................................................................	0	334	627	821
+12515	PF12680	SnoaL_2		SnoaL-like domain	Bateman A, Finn RD	agb	Jackhmmer:Q11X43	Domain	This family contains a large number of proteins that share the SnoaL fold.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.33	0.72	-3.61	623	6223	2012-10-03 02:27:24	2009-11-24 16:13:34	2	57	1993	66	2137	7931	2945	104.20	15	64.43	CHANGED	l.pp...a.h.c....s.h.s......st...-...h....c....s.h....t........sh....h....u....sD.h.h...h....p.........ss.....sst...........hp.Gtp.....shtp........hhpthht.................hsshphp.lp.ph..........hss..G....c.........tlss..p.....hphph...........................sup.thph.................pshs..h..acl...c...c.G...+..Isch	...............................................ta.h.p....s.h..p........st...D....h.....c.....t.h....t........sh....h....s....sD..sh.....hp..............ps.....sst......................hp.Gp.p.....sltp.......hh.tphh.t........................th.s.s.h..p..h.p...h..p.ph............hss....G.....s.....................hs...hs...p......h.pht..........................................s.up.th.ph.................phhs...h..h.ph....c...s.G...+Ist.........................................................................	0	618	1329	1765
+12516	PF12681	Glyoxalase_2		Glyoxalase-like domain	Bateman A	agb	Jackhmmer:Q187Q5	Domain	This domain is related to the Glyoxalase domain Pfam:PF00903.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.39	0.72	-3.44	429	20226	2012-10-02 15:00:03	2009-11-24 17:23:30	2	76	3531	174	6614	23813	5121	112.40	17	76.73	CHANGED	lhs..p..D..hpt..utpFYpph.l......Gh..p...htt...................pt...s....p..h......sh...h.ph......s................h..h.............................................t....h..tt.hh.....t......h..t...........................t...t.....ss..........ts........st........h..tl.....t..h.pl.......s.-....l..-s..h...hp...pltst.................G......sph..............h..p....s...s..t.......p...........hsh..............s........p...hhh..l..tDP...-Gshlplh	.....................................................................................................................spD..hpp.u...h.pFY..p...ph...l.........G.h...phtt......................pt.s....s..h........sh..h..ph......s...........t.h..........................................................................................................................t...h...t...hh....t.......t..............................t...st....ss........ss..............st................hp.l............s.h.ts.............s..-...........l....-...s...h....hp.....c...l....tst..........................G.....sph..............................h..p....s...s..t.........p.............tsh...................................u...........p.......hh.h..h...tDP...-Gphlpl................................................................	0	2073	4288	5609
+12517	PF12682	Flavodoxin_4		Flavodoxin	Mistry J	jm14	Manual	Domain	This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.05	0.71	-4.87	5	1133	2012-10-03 05:08:30	2009-11-25 13:20:28	2	15	627	3	273	1382	49	149.40	28	80.50	CHANGED	KsLVAYFSso.....................GNTKhlAEhIAEtTGADLFEIcPscPYTctDLDas-ptSRSSVEMpDspuRPAluscl.shEDYDVlFlGFPlWWYsAPpIVsTFlEuYDFuGKpVIPFCTSGGSGlGsotKcLQ.pAsPcAolLEGptlsRGpl.......oRcpVs-Wlc+L	................................................................+hLlsYaSto.............................................G.sTctlAc.....hI.s......c......t.....h.......s.....u.......D......l.....h....c..I.p.....s...t...p...s...Y..s..p..............s.......a.p......s.t......h.......pp......u..p..t..............E.......h.....p..p..........s.t+..P..t....l.....p....s..p.....h.......s..h.sp....Y.......DslalGaPlW.at....p.hsh....sltoF...L....c...p....h.......-.......h.............s...G.K...pl..h....PF.s.T...p...u....G...o...u....hu..p.......s....h....pp.l...p....p.h.........t.....s.....s..s..p....h.h..p.Ghh..h.....t..s.t.....................t..t...lttWlt...........................................................	0	90	199	240
+12518	PF12683	DUF3798		Protein of unknown function (DUF3798)	Bateman A	agb	Jackhmmer:Q183D5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 247 and 417 amino acids in length. Most of the proteins in this family have an N-terminal lipoprotein attachment site. These proteins have distant similarity to periplasmic ligand binding families such as Pfam:PF02608, which suggests that this family have a similar role.	21.00	21.00	21.80	34.00	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.40	0.70	-5.31	16	148	2009-11-26 10:12:10	2009-11-26 10:12:10	2	1	90	2	26	138	5	260.70	50	68.55	CHANGED	ssa+IGllTuTlSQuEDpaRuA-thhccYGs................hIhpsTaPDNFssEhETTISplluLA-DPchKAIllspuhsGshsAhpKI+EcRPDIlhluusspE.......DsshhupsuDlshssD.lspGhslsptApchGAKsFlHhSFPRHhu.hpslupR+shMccsCc-LGlcFl-sssPDPsoDsGsuusQQFlhEclPchlcKY.GK-TAaFuTNsuhpEPll+plhEtGuhasptssPSPhhuYPuALGl-lstsctGDastlhcplpcKlsctGhsGRhG	.....................................saHIGllTsoVSQSEDshRGAEtllc..cYGsssp...........GGhIpplThPDNFMpE.pETTISplluLADDPpMKAIVVspulPGTstAF+cI+EK..RPDILlhsupsHE.......DPshlsssADlsls..sDtluRGYlIltsA+chGAcpFlHISFPRHhS.YEhlu+RRsIMcpsCc.DLGhcalt.oAPDPsSDVGVsGAQQFILEpVPpWlpKY.GK-sAFFsTNDApTEPLLKplst.h.GGhFlEA-hPSPhMGYPGALGl-ho.c-tGsastILc+VEcsVlttGGsGRhG...........	0	17	25	26
+12519	PF12684	DUF3799		PDDEXK-like domain of unknown function (DUF3799)	Bateman A	agb	Jackhmmer:JCSG target 392282	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in Pfam:PF01930.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.58	0.70	-5.02	19	347	2012-10-11 20:44:46	2009-11-26 15:13:40	2	3	303	2	52	350	410	226.40	26	57.25	CHANGED	cYhSsSpaKpF......hp....CEAtAhApLpGcWp......ppsssALLVGNYVHS.YFES.csc-pFhc.......pcschhoph.....pKGpL+u-FphA-pMIpsLcsDchFtphYp.G......-KElIlTG-lhGl.WKuKlDslNhpcshFl.DLKTsc.sl+.pchWsp..t......ssFlctasY.lQhAlYpEl..lcQ....phG.cphpPhIhAVoKpssPD+sllplsp....phhctuLcplc.pslp+lhpVhpGc.cPs+CG+C-YCRus	..................................................................................................................................................hShS.hcph......h.p......s.A.hhhhc..h....pu...hp.......ppcsps.L.lGshhHs....h.h.Espc......hpp.cFhh............tppp.chh.ppst..........ppshh.tc....-.h...c..t.h...-hMh...ps..l..ht..pshh..p.....h..l..hp...G...................Epp..l..h..h..p..sp.....s.G...l..h....h+s+.Dp.l.....s.......-.......h..p....h....h.....h.D.lK..TTt..D..lp..................pa.....tshh.satYclQhAhYp-h..hct......ph..G..p......t.h.p.h..l..h.lul.Sc.p..h............shplhhhsp......-th..t..pp.....hc.pslpplhcshpsc.p.P..............................................................................................................	0	20	40	44
+12520	PF12685	SpoIIIAH		SpoIIIAH-like protein	Bateman A	agb	Jackhmmer:Q18B63	Family	Stage III sporulation protein AH (SpoIIIAH) is a protein that is involved in forespore engulfment. It forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.  This family of proteins is found in bacteria, archaea and eukaryotes and so must have a wider function that in sporulation.  Proteins in this family are typically between 174 and 223 amino acids in length.	25.80	25.80	25.90	25.90	25.50	25.70	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-10.92	0.71	-4.81	84	427	2009-11-26 16:59:55	2009-11-26 16:59:55	2	2	414	3	98	318	4	186.60	23	93.45	CHANGED	+pthllssLslhls...luuY...................hsYths...tsttpspsttpptp..t.t.............................................................................................................................................ssspsspsssssspsspph.....................Fsph+lpREppRucph-pLppIlsssssop-pKpcAhpphhplsphtcpEttlEsllcuK.GapDulVhlsss.p..lsVlVpspp..LocscsspIt-lVpcp.sslssppltlp	......................................................pp.hllshLslhlslu..sY.....................Yhhs..p..t...sssssts.sp....t...tttt..p......t......................................................................................s...................................spppspppssssspsssph..........................Fsph+hphEppRucphppLppllsss.ssotppKscAtcphttlsphpppEttl.EsllKup.GapDulVphss......s..p.lpVsVpusc...hoppcsspIhplVpppss..t..pl.l...................................	0	48	79	87
+12521	PF12686	DUF3800		Protein of unknown function (DUF3800)	Bateman A	agb	Jackhmmer:Q183E5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 215 and 302 amino acids in length. There is a DE motif at the N-terminus and a QXXD motif at the C-terminus that may be functionally important.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.38	0.70	-4.72	127	700	2009-11-26 17:12:18	2009-11-26 17:12:18	2	2	610	0	183	611	68	214.40	13	82.60	CHANGED	hla.....lDESGshsh...............spshasluulhhppppht..phtppht.phppchhhtt................................................................l+tscltpp...ptt.....................................pplhshltpht...............hhhhs..hlhppthhppt...........htttt...............aphhhphllcclt........................................ppsp.....phtlhhD.....pppppptppltphh..................................htthtppthhpph..lpthhhhcScp...t.....thlQlADhlss....sltpthph...............................................................pptppphhphl...cptht	......................................................................................hahDESGphs..................tp.has..luu.l.hh..t.pp..hh....ph.p.ht...phppphhh.t.................................................................................................l+hsph.pp.....tht......h.................................................................................................................pthhphhtp..........................hhhhhhhh.ppp.httt..................................tt..................aphhhp.hhlppl...................................................................tptp........phh.l.h..hD........pppptpt.p.p.l..hthh.......................................h.ttthhtth...h..p....hhhhpScp........p.......hlQlADhlss......sltphhp................................................................th.................................................................................................................................................................	0	71	127	162
+12522	PF12687	DUF3801		Protein of unknown function (DUF3801)	Bateman A	agb	Jackhmmer:Q187F8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 158 and 187 amino acids in length. This family includes the PcfB protein.	22.80	22.80	23.00	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.32	0.71	-4.75	54	614	2009-11-27 16:03:44	2009-11-27 16:03:44	2	1	330	0	47	447	58	155.40	25	85.15	CHANGED	u+hLttultthLpchcKpp..................................GKpol+pLhcp.stslpslclscp..slKpFc+hAKKYGlcaulhKDpsssss..pa.VaF+ucDs-slstAFccastcplppp..................................................................................................................................................................................................................................................c+PSl+ppLpph+.tptttp.....................php+....pps+pKc+	..............................................p.l..hhtthht..ph....pcttt...............................tGc....plKcLh+.c..up..LpsIplscs...slKchc+phcKaGVsFulhKD+psp......pY.lFFpu+Dhcsh....ptAFcc.hhsc.phc+pcc..............tphpc.hp..................................t................................................................................................................................................................................................................................................................................................ppp............................................................................................................	0	30	38	42
+12523	PF12688	TPR_5		Tetratrico peptide repeat	Coggill P	pcc	pdb_3kni	Family	BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions.  This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the Pfam:PF00515, Pfam:PF07719, Pfam:PF07720 and Pfam:PF07221 models.	21.40	13.60	21.40	13.60	21.30	13.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.62	0.71	-4.07	8	427	2012-10-11 20:01:02	2009-11-30 13:29:35	2	50	408	0	96	763	182	114.00	31	46.94	CHANGED	upAhFERAGAhDSsG+pscAlPLYRcALAsGLsGspRRRAsIQLASSLRNLGcs-EuLALLpsphsthPuDELssAlsuFhALsLsutGRscEAluhlLtAlAsHLP.....RYQRShpsYAptL	.................................................h.a.hA.haDshGh.E.pcAlshY..cp.....A...l.......s.......t......s....L...s.....u...c.....p...h...p...t.....A.h..l.....s......L..u...SohR.sl.......Gp.h-pAlslL...p.s.....s...l...t....c....a.....P.....s.......................s.s....s......h..c..s.F..h...u...h..sLa..s..l.uc..pc..E...Alphh..Lthl.....s.....pps...................ap+ult.Ytt.L..........................................................	2	34	69	88
+12524	PF12689	Acid_PPase		Acid Phosphatase	Mistry J, Wood V	jm14	Manual	Family	This family contains phosphatase enzymes and other proteins of the HAD superfamily.  It includes MDP-1 which is a eukaryotic magnesium-dependent acid phosphatase [1-2].	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.08	0.71	-4.62	43	326	2012-10-03 04:19:28	2009-11-30 15:33:38	2	10	244	6	217	336	18	152.80	32	75.86	CHANGED	.lP+LlVFDLDYTLWPhasDs+..................lssPh+tpsss.........plh........DctGpplphYscspsILt.......tLcs.........+ulplAhASRTssP...clAcphLphLcls................th.hhchF....st.lEIas....G..oKspHFp+lpc......coGl..sapcMlFFDDEpRNhpshop.LGVshhhl..ss...GlohphhccGLppapcp	......................................hP+lhVFDLDaTLWshas-sc.........................................htsPh+..tss....................thh..............................Dp..tup..ph.phascl.tlLp..tLcp.........pul..luhASRT..sts...-hApphLch.hcl.......................................phF.....sh....hpI.as......u......sKhpH....Fpplpp........................poul...a..pp.M....lFFDDEtR....N.........hps...p..............lGVs.........h.........hhl..s...Ghshp.hppGl.tatt.t.............................................................................	0	68	123	176
+12525	PF12690	BsuPI		Intracellular proteinase inhibitor	Mistry J	jm14	jcsg_3isy	Domain	This is a bacterial domain which has been named BsuPI in Bacillus subtilis.\	     This domain is found in Swiss:P39804, where it has been suggested to regulate the major intracellular proteinase (ISP-1) activity in vivo [1].  The structure of proteins in this family adopt a beta barrel topology.	27.00	27.00	28.20	27.10	23.40	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.68	0.72	-4.27	39	149	2012-10-03 16:25:20	2009-12-03 15:47:41	2	11	122	1	58	124	3	82.90	27	39.88	CHANGED	slphplslpNpsscslslpFsSGQcaDlhlh...........DppGcclacaScs+hFTQAlpphslpsG-shsap.tphs.ts........sGsY.plps	..................s.lphpholpNpsspslslpasSGQ+aDhhlh...........spcscclapaS..cs+hFsQshp...spslpsG-ohsap.tphstts.........stY.h.................	0	23	39	49
+12526	PF12691	Minor_capsid_3		Minor capsid protein from bacteriophage	Coggill P	pcc	manual	Family	This family is from one of three adjacent genes, all of which are involved in formation of the minor phage capsid.	20.40	20.40	22.40	23.90	19.20	18.50	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.63	0.71	-4.47	14	101	2009-12-03 17:53:01	2009-12-03 17:53:01	2	1	99	0	8	73	1	131.10	31	98.94	CHANGED	M.....DhhphLtshlps..hthPhKschshl.spp-........ululh.lPuup..sppYh-GscplshpaplshKocsp.cAppsl.tIsstLspl.thc......l.ShssSapacshslhspPthsctsspGhalYhhshssclpl...ttp	......................M....DFhssLhptIcs....thsh.....ch+hshl.spp-........slslh.hPuuc..ppcYhDGsp-hShsFplshK.oK.....sptpupsslatIsshLsph....s......L.StssSapapsh-l.spPhlssts-pGhalYslshps+l.l.c.t..p..............................	0	3	6	8
+12527	PF12692	Methyltransf_17		S-adenosyl-L-methionine methyltransferase	Mistry J	jm14	jcsg_3iht	Domain	This domain is found in bacterial proteins.  The structure of the proteins in this family suggest that they function as a methyltransferase.	18.10	18.10	18.10	18.20	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.94	0.71	-4.55	18	51	2012-10-10 17:06:42	2009-12-07 14:19:28	2	1	41	2	19	80	17	158.40	46	96.81	CHANGED	MSRLDSFIRRhoAQRDsLNaAsspsusls.GsVLELGLGNGRTYcHLREhhPsRRIhVFDRslsuHPsSsPP--shllG-lccTLst.ltthGssAuLsHADlGsGsc-KDsspAshlSPlIAslLAsGGlhVSupPLh.a.uLpplslP-ulssGRYFhYRR	.................MSRLDpFIcRhoAQRDhLsasts.......pl.ssh.s...Gs.V.hElGLGNGRTYcHLREhhPsRcIhVFDR.s.ltuHP........uS..sPsp-c..h.lhG-.lc-TLss.h.thGssAuLsHADlGsG.c-+DsspushLuPLlsslLAsGGlhVSupPL..assLptlPlP-ulstGRYFhYR+...................................................................	1	2	11	12
+12528	PF12693	GspL_C		GspL periplasmic domain	Bateman A	agb	Bateman A	Domain	This domain is the periplasmic domain of the GspL/EpsL family proteins. These proteins are involved in type II secretion systems.	24.10	24.10	24.10	24.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.83	0.71	-4.47	23	933	2012-10-02 17:03:51	2009-12-07 17:13:58	2	6	819	2	175	737	69	154.50	24	39.73	CHANGED	pppht.W..RhlshhhulhLllhlsttshphaphtppupthptpuppla....pphFPsppplhs....ptQhpppLpph...tutssssshlshLutLtshls..sssslclpuLcacupctcl+l..plpusshsth-......phpppsupt.aplp......uphpppssplpuphslc..s..p	..................hthW....Rhshhshhlhlls....h....sstpslphap.lp...ppssthcsp...spcha....pphF..Pppp+..ls..s...h+pQhpppLpph.......pstsss......s.ph...lshL...stlsssLt......ph.s.s.lp..l...puhsacppctpLpL......phpu...tshssh-......phpptLspp..a...lp........sth.ppps.-.sVpGthsl+..p......................................................	0	38	86	133
+12529	PF12694	MoCo_carrier		Putative molybdenum carrier	Mistry J	jm14	jcsg_3imk	Family	The structure of proteins in this family contain central beta strands with flanking alpha helices.  The structure is similar to that of a molybdenum cofactor carrier protein.	23.10	23.10	23.30	25.30	22.40	23.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.75	28	67	2012-10-01 21:16:48	2009-12-08 13:32:46	2	3	58	1	34	73	15	137.60	41	76.45	CHANGED	IlSGGQTGVDRAALDsAlstGlspGGWCP+GRpAEDGslPs+Y..LpETssssYttRTchNVpDSDGTLIls.pGcLsGGTthThchAcctsKP.....hLll...phspsps..sptltpWltppslplLNVAGPRESpsPGIaptspshLppllp	............IlSGGQTGsDRAALDhAlt..hsl..shGGWCPpGRhAEDG.lss...cY.......LpEhss.ssYt........tRTchNVhDSDuTLIls......tu.t..LsGGo...thThphApchtKP.....hLhl..........phst...tps...sttltpWltppplplLNVAGPRpSpsPuIhphshphLpthh.t............	0	17	28	32
+12530	PF12695	Abhydrolase_5		Alpha/beta hydrolase family	Bateman A	agb	Jackhmmer:Q186B9_CLOD6	Domain	This family contains a diverse range of alpha/beta hydrolase enzymes.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-11.17	0.71	-4.44	308	16512	2012-10-03 11:45:05	2009-12-10 17:24:36	2	168	4213	56	5692	81995	21732	192.90	14	59.02	CHANGED	sllhh.....HG....s...........ss.....s...t..p.....s....h.......t....h.u...p.......tL.spp.G.hsllhh..................................ch..s...t.t...ss......s...........tsts......................phpphhpt....................................................................hh..........shp...pl...hlhGcSh.Gut.suh...hhAs...................................................................................p...p...t.....pl.p..ull....hh.u..s....................a...........................ss........hp........plt......p.hph..........................................................PlLllt...Gsp...Dphs.......s...p.ph..pp.........................................................hhpt..hs....sst.....p.h..........................................hhl.p.Gu.sHs	.......................................................................................................................................................................................................llhh...H..G.......h...................ss...........s.......t....t...........t........h............................t.......h....u....p........................tl.....s....p........t.....G.......h.......s..........l...l.h.h.........................................................-h....t...s...h...ut.......s...................tst.........................................................sht..t.hlp..h.....................................................................................................................................tths.......s.p..p.l....s..l..h....G.......t..S.h..G.u.t....h..u.h.....t..h..us......................................................................................................................................................................................................................................................................p.p....t......pl...p.....u.l...l........h..h.u..s.......................a..................................................................sp.......t...........t.ht........t....th......................................................................................................................................................................................................Ph.L..l..l...p........G..p.p.......D..p.hs............sh.....p...t...s....t.p................................................................................................h.h.p..t....ht...........t.h.......p..h.....................................................................h..h..h......s.stH........................................................................................................................................................................................................................................................	0	1991	3619	4800
+12531	PF12696	TraG-D_C		TraM recognition site of TraD and TraG	Coggill P	pcc	Pfam-B_1146 (release 5.4)	Family	This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation.  These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems [1]. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.59	0.71	-4.27	232	1419	2012-10-05 12:31:09	2009-12-11 11:56:10	2	13	918	0	310	4110	322	119.20	22	19.22	CHANGED	tlhhlLDEhuslspl.sphpphluhhtutGlphhhlhQshuQlcp...hYG..c...ptt..cslh.uNsss....pl.hhs.....ss..-.....pTschlSc.hlG....ppol..tp.tpptpt............t.....p..........p+sLlsssEltplsp	.........................h.hhlDEhssl....h..h.....h......p.....t.....h....tp.....hls.........put.......uttltls.lhhQsh.uQlct......paG....c.....tps....pplh.sNs.sshl..hht....sp...ss..pTAchl..oc..th.G...ch..phtp..pohststps......................................psphphttp.llsssclhsh.......................................................................................................................................................................	0	90	215	280
+12532	PF12697	Abhydrolase_6		Alpha/beta hydrolase family	Bateman A	agb	Jackhmmer:Q186D8_CLOD6	Domain	This family contains alpha/beta hydrolase enzymes of diverse specificity.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.69	0.70	-4.48	785	53202	2012-10-03 11:45:05	2009-12-14 16:32:03	2	430	5271	368	19769	83722	24117	238.80	14	74.29	CHANGED	l.l.l.l........H..G....h...........s....s..ss................t.t....ap..t............l.h...p...tL..s............p.....s...........a............p.........l...............hs...h.....-...h.........G.....t...G.....t......o.......s.....................................................t.....t........................................h.s....h....................t...p.h............sp................................s.l........................................t.t........h....l.....p.....p......h.sh............................p....p.....s....................................................h...l..l..GaS.h.G.u.......h.h...s.ht....h.s.......................tp.....t...s..p.............tl..ps..........l..l....hhs....ss.s...........................................................................................................................t..........t.hhp..............thh...............tth.t.........h.....tth............t......t.t.......hht..h....h...................ttpth............p..phh....................................pt........................tht.th..hp.hhtt........................................................................tttth...t....pt.h...sp........h........s.........h.P....s......hh..l.....h.....upp.Dp..............................h.h.....s..............p.th........................pph...t....p..t...h.....s..s.........s.........p...h...h......h..l.s.....t..u.u.Hh....h...h.h...p...p.....s...p.t...l...sph	...........................................................................................................................................................................................................llhl.H...G.....h................s........s.st...............t......ap..t............................h.h.....t...tL..s.......................p.....s...................................a................................p...............l...........................l.s.....h...................D........h...................h....G.............h.....G...........t............S.......s................................................................................................................................................................................................t.........................................................h..s....h....................................................p...p...h...........................s.p...................................................................s...l................................................................................................................................................t..t.......l.....l.......c....p......hsh...........................................p..p...h........................................................................................................h...l....l...G.a...S..h.....G...G............h.l.....u...h.t.....h.u.........................................................................tp.......h..P.p..................................pl..p.s.......................l......l.......lhs......ss.s....................................................................................................................................................................................................................................................................................t.h.h.t.........thh.........................t..h......t..............h..............tth.......................t....t.......hh...t......h.h...........................t.t...t..h.............t.t.h.h..............................................................................pt..........................................t.t.h.h.t.hh................................................................................................................................ht.tsh....h.........t..t..h.....tp............l............p...............h.P......s...............ll...l.......h..................G..p..p...D...........................................................................................................h.hs..................p.hh...............................................pt.h.......t........p...h......h......s.....p...........................s.........................p....h........h.........h...h............................t...s..u.Hh..........h...p.......t......t...h...h........................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	5860	12066	16584
+12533	PF12698	ABC2_membrane_3		ABC-2 family transporter protein	Bateman A	agb	Jackhmmer:Q17ZU3_CLOD6	Family	This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].	31.60	31.60	31.60	31.60	31.50	31.50	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.58	0.70	-5.41	220	16168	2012-10-03 10:13:34	2009-12-15 10:08:38	2	60	3863	3	4148	18062	2565	336.20	12	63.90	CHANGED	+t.h....l..h.tll..h..P...ll.h.h..h...l.hs.......hh..h....h....htht....p..............pshpl.................sl.lsps......................hspp....hh......................................................ptlp........s...p..s..p......hp....................thss....hp.psp..pt.l....ps.t.......p.hp..u.hh.h.......l.spshttth................................................................................................t...phphhh....ssps.h.....pts............................................ttltpt..lp..............................................................................p...l........hpt...................................h..pthshsh..p..h.hsh.................t.ptt.....p..sh....tt.......h.............hhs......hl...h..hhh....hhhs...sh....h..h.sh.......t....l....s....pE..+p.s.ph.h.c...hhh...so..l....shhp.......hhhu+.......h....lshhlh...th...h....h......h..l.h.h......h.......l.......h...hu..................................................lshs.....sh...........h.h...h........l.....lhh.llh.hh...shss..........luhhl....utl....h.p...st.......tp..s.......hh...hshhhh...........h.h.hsh....hh.sh...h..h.......h.s..t.........s...........sh......h..t.h....l.....hp.hl..P.hhs.hhhh..h..hp.l.h................hss.....hp............................................lh.....hslhhl.h...lh...sll....hhh...lshh	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................h.........h..hs..hh.h......h...h...................h.h.............................................................tth..h............................sl..hs.p........................................stt...hh......................................................................................................................................................................pt.ht.............t.................ht.........................h.s.....t.pht.......tt..h......................pp.t............p..h......h...hl...............................h..s.sht.tth.............................................................................................................................................................................................................................................................................h.t.hhh.....stt.........h.....................................................h.th......lp................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.....h........ht................................................................t.........hph...p....h.h..............................................hs.t.......th.....t.............h............................hhs........hh.....h..hhh....hh.hs.....sh......h....h.sh..............l..............s.....pE....+....p..p....t...h...h..c...............hh.h................s.s..s...l.....s......hp............h.h...hu+..........h.......ls....hh..h..l.......sh.......lt.......h...........h...l...h.h.....h.......l..........h..hs.......................................................................lsht.......s.................h...h......h...........h.......hhh....hlh..hh....s.hhs...................huh...h...l.......us.h........h.p...s.................tt..s.............h..hh.......hhhhhh.................................h.hh.h........hu..sh.......h.s..............h.p..t...............h.s...................................th..........h...p..h................l............................t.........hh....P..hth..h.h.ph.....h...tph..h............................htt........p.........................................................................................................................hh.......thh.hl..h...hh..sh.h.hhh.h...h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1433	2455	3318
+12534	PF12699	phiKZ_IP		phiKZ-like phage internal head proteins	Hardies SC, Coggill P	pcc	Hardies SC	Family	Phage internal head proteins (IP) are proteins that are encoded by a bacteriophage and assembled into the mature virion inside the capsid head.  The most analogous characterised IP proteins are those of bacteriophage T4, which are known to be proteolytically processed during phage maturation, and then subsequently injected into the host cell during infection. The phiKZ_IP family consists of internal head proteins encoded by phiKZ-like phages.  Each phage encodes three to six members of this family [1].  Members of the family reside in the head [2] and are cleaved during phage maturation to separate an N-terminal propeptide from a C-terminal domain.  The C-terminal domain remains in the mature capsid.  The N-terminal propeptide domain is either mostly or completely removed from the mature capsid. In one case, an unrelated polypeptide is embedded in the propeptide and also remains in the mature capsid.  The phiKZ-like IP proteins are not discernibly homologous to the T4 IP proteins, and it is not known if the phiKZ-like IP proteins are injected into the host cell, or have some other function within the head. The alignment and HMM model exclude most of the propeptide region, but include the cleavage sites.  The first 100 residues, including the cleavage sites, constitute the most conservative part of the seed alignment.	22.30	22.30	22.30	22.60	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.87	0.70	-5.52	14	27	2010-01-13 14:45:13	2009-12-15 10:40:50	2	2	9	0	0	28	0	299.70	13	68.77	CHANGED	tus.tho........ppstpshhssLEslsppl.thcthshu..hEsasss.pst.tthh.....slE..............slpctlppsscphhchlp+lhphlpphhsphpsulpplpc+hspLhc+hpsh..........tp.s.tpplslp.s..pclhhsGpFl..............shhhhsh.phsshhsptasp.hhshlpphschlsshphscp.hsphppthphhsc....................................htstthhhpustlsGNptlhhssspht.s..................hpa..lpsputsss-........hsl-s.sssp.lppplctlpphlptlpchppttpchp........-plcphh-shpp.sth..scps......hcshp-sstclhcsstshlpshssplsshl	..........................................t....ths.pththh.sshcphptph...pthshu.......hEshs.ss.p....th......sh-..............slppthpphhcchhchlpplhshlpphhpphtsuhpplpc+hspLhpchpph..............................tp.s.tpphplt.s..thlhhsupah.................hhs..phsp.htpshsp.hhphhpphtthhpsh.hppp.h.sthtphhphhtt.........................................hh.ts..lsGNthlhhs..tsthh..........................ttpt..st.p........hplch.sstp.ltphlptlpt......hh....phhtthpthpppht........ctlpp.hhpthtt.ttt..spt.......hphhtps.tchhps..thht.ht..ht............................................................................................................................	0	0	0	0
+12535	PF12700	HlyD_2		HlyD family secretion protein	Bateman A	agb	Jackhmmer:Q182V7_CLOD6	Family	This family is related to Pfam:PF00529.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.97	0.70	-5.28	70	15970	2012-10-02 20:27:15	2009-12-15 12:46:01	2	62	3553	31	4798	25329	5154	298.90	18	77.75	CHANGED	plppsslt..pshshsGhl.......l..+.pEphlpuptsGhl...phhlp-Gp+VppGshlhslsssphtpphhpt.tt.t.....hpphp....................................t.h..................h..thppp.apthht.ppphpthh.phpp.ptt...........................tthptphp...................................................lpushsGlls...hDuhEth......................t.hp.....................ppp..hpss....stlpsusslh+llss.pp........hplsh.l..s.....ccphpplp......p....sps..l...................plphts.spshpup..lp.ltpt......sp....t.hshlphsst.htchhspRhlclplhhpp.psGLpIPpoAlspcs..........................................................................................................stpGVYsl.ppu..hspF+plc.....lltp..sccahlV.................tpG.Ls.hDplll	....................................................................................................................................................................h............h.h.G..p.l...................t.....s...p.p...s...t...l...s.....s...p.....s....s........G........p....l.......tpl.........h........l.......p..............G..pp.......V.......c.p.G.p.h.L.s.....p...l...c...s.......s...p.......h....p....t....t.....h....p......p......s...p...u...t....h...t...t.......p.t...t...h..tp.h.p........................................................................................................................................................................................................................................................................................................................................hp..h.....t.....c.........p.....p...l.....h.......p.......p........t..........h.......h.......s.......p.......p.....p.......h.....c.......p.......s..p...s..p..h..p.t.spsph.........................................................................t..p...th.tp..............................................................................................................................................................................................................................................................................................lp.A.P.h.s...G.....h...ls....................................................................................................................................tht.....s.p....G............ph....l.......s......s........u.......p..........s.........l......h....p...l.....s...s...h....ss..................................h.hl.p...h...p...l......s...................Ep..p....l....s..p....l..p...........................h..................Gp.p...h........l.....................................................................p..h....t...s......h......s..........s.....p......p....h......p...up........lp.t..lsstss................................tst..........s.h..t..s...p...h.....p.........l............s.........s............s.......s........t..........t.............l.........h.......s..........G.....h.......h......s.......p.....s.........p.......l..................h.............t...........p......p.......s............s..........l.....h............l....P.t...p......A..l.....h.....t....p..s...................................................................................................................................................................s.t...t...h.....V...h...l.......h....p....ps..................ph....p.h......p.............V.p...................l..u..t............ss.t.....s...l........................hpG..Lp.G-pll..................................................................................................................................................................................	0	1643	3132	4033
+12536	PF12701	LSM14		Scd6-like Sm domain	Anantharman V	pcc	Anantharaman V	Domain	The Scd6-like Sm domain is found in Scd6p from S. cerevisiae, Rap55 from the newt Pleurodeles walt, and its orthologs from fungi,  animals, plants and apicomplexans [1]. The domain is also found in  Dcp3p and the human EDC3/FLJ21128 protein where it is fused to the  the Rossmanoid YjeF-N domain [1,2]. In addition both EDC3 and Scd6p are found fused to the FDF domain [1,2].	25.80	25.80	25.80	26.80	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.07	0.72	-4.18	156	564	2012-10-01 22:42:21	2009-12-15 16:50:39	2	12	284	5	358	507	3	94.00	40	21.39	CHANGED	..ssssaIGSpISLISKu-.IRYcGh.LasIss...ppST.......luLps.....................V+SaGTEsRtps.......lsspsplY-aIlFRGSDIKDLpVt-ssp........shssDPAIlpsph	..................hssalGSpISLIScsp.IR...........Yp.GhLhsIss...cpuT.......luLpp.............................................................VRSFG.TEsR.sst..........lsPpcpla-.YIlFR..GSDIKDLpVt-sst...........shspDPAIlt...h............................................	0	104	170	266
+12537	PF12702	Lipocalin_3	DUF3803;	Lipocalin-like	Coggill P	pcc	JCSG_target_392987_3hty Pfam-B_17140 (release 24.0)	Domain	This is a family of proteins of 115 residues on average.  The family has two highly conserved tryptophan residues. The fold is very similar to the lipocalin-like fold from several comparable structures.	20.20	19.40	20.20	19.40	20.10	19.10	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.13	0.72	-3.96	17	79	2012-10-03 08:47:39	2009-12-15 17:12:47	2	3	61	16	8	74	2	90.60	30	55.05	CHANGED	sptsllGsWlpPlss.s.sthQGhpLctsGpAoSINMsTLhYcp....................Wc..ppGspLlLoGpShGNst..s..hp-ThpIcpLTscoLlL......cptshplpYs	.....................pllGsWspPhshps.sthpGhplcpsGsAS.SI.NMsoLpYcp.........................Wc..hpGs..pL.lLpGpShGstt..s..hssohpIcplopcoLhL......pstt........................	1	6	7	8
+12538	PF12703	plasmid_Toxin		Toxin of toxin-antitoxin type 1 system	Gardner P, Coggill P	pcc	Gardner P [1])	Family	This family is the toxin of a type 1 toxin-antitoxin system which is found in a relatively widespread range of bacterial species. The species distribution suggests frequent horizontal gene transfer.  In a type 1 system, as characterised for the plasmid-encoded E coli hok/sok system, the toxin-encoding stable mRNA encodes a protein which rapidly leads to cell death unless the translation is suppressed by a short-lived small RNA. The plasmid-encoded module prevents the growth of plasmid-free offspring, thus ensuring the persistence of the plasmid in the population. Plasmid-free cells arising after cell-division will be killed because the stable mRNA toxin is present while the comparably unstable anti-toxin is rapidly degraded. Where the system is transcribed chromosomally, the mechanism is poorly understood [1].	19.40	19.00	19.40	19.00	18.80	17.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.39	0.72	-4.16	6	28	2009-12-16 11:43:50	2009-12-16 11:43:50	2	1	28	0	8	18	0	70.20	59	92.47	CHANGED	Mss.p.hpstpslHpsAh.LuuLcalDQcsARpLu.hAEAVANhFMVVFYQAETGRATptDFpEAMsAlRQuhp	.......................MsTtHsIE..spQAlHQAAhpLAALEaIDQcsARplhPlAEAVANhFhllYYQAETGRAT.pDFpEAhsslRQsh.p..	1	3	4	7
+12539	PF12704	MacB_PCD		MacB-like periplasmic core domain	Bateman A	agb	Jackhmmer:3ftj	Family	This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein [1]. Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.22	0.70	-11.73	0.70	-4.77	1392	21380	2009-12-16 11:56:13	2009-12-16 11:56:13	2	26	4469	3	5700	17502	5573	229.30	13	48.61	CHANGED	Ah+slhpp......+hRoh...Lohl......G..lsl..G..luu..llsh.hu.ls.pu...hppp.htpp..h.....tp....hus..sh.......lh...lpssts..................................................t.tt.t..sl.s..h.ps.hpt....lp............ph.s.t.lpsl..ss....th..s....................hplph..............sspstss...............ph.G..................ss.s.s.hhph............h......s..h..pl.hpG...chhstt.-...............tpss...llu.p.sl.Acp.las.pt.t..........s.....lGcp..lpl...............................s.....s......s........................hpVl...Glh.....p.............sp....st....................t..s................ttlhlPhsshp..........................phhtt...................................tthsplhlp.........hpsss..s.hsp..................s.ppplpp....h	.....................................................................................................................................ttlh..t.p.......ph+.....s.h......l...s...h...l..........u.l..sl...u......l.sh...l.l..s..h...h.u..l.h..pu...h..p..p..t...hppp....h..........tt....hss....sh.........lh......lp.ttt.................................................................................................t.th..s.....p..p..hpp..lp..................ph.s..s..l...p......s.......s...ss....hh...s.................................s.lph..........................sspp.tsh............................................................p.hhG..........................ls..s..s..h.hph....................hs.h....pl.....hp..G.....c..h......h.s...t.......t...........................................pptl.................l...l..s..p......p.......l....A.............cp...hth..p.................................................lGc.p...l.pl...............................................................................s..t.....s.......................................hpl.....s......Glh....p......................st......t........................t.s......................................thlhh.s..h.sshp.........................................................phht..............................................tthsth.hlt........hp.ss...p...tt.h.......h....................................................................................................................................................	0	2422	4192	5077
+12540	PF12705	PDDEXK_1		PD-(D/E)XK nuclease superfamily	Bateman A	agb	Jackhmmer:Q18AP1_CLOD6	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.99	0.70	-5.01	258	8235	2012-10-11 20:44:46	2009-12-16 13:18:01	2	43	4486	8	1945	8551	4890	244.70	14	25.38	CHANGED	phSsSp.lcpatp.CPhpaah..ph.hh............plpttp...........th.pshs...............................hGslhHp......slcp..............hhp......................................................p............hptp.................................th...t.............................................ptt..thtpt.h..pt...................h.h..pp...htp..hht.........................................................................................tttt.......hp...hth.....Ehphp........hph.s..........................................sl...pl...pGplDRl........-tt....ssp.......................lpllDYKTupp..................sh....shp..........................................ch.....h.....h...ph..QLhhY.hhshtptt..........................s.pstsss....hhah.p.hppstht.................................................................................................................hp.ths....ppp..hpt..hp...p...pl....pphh.p.pl.t....p......httt...............................................h..t...psppsC.....p....a....CsapslCt	................................................................................................................................................................................................................................................t...............................................................................tshp....................................hGs.hhH.p..........hh...c.p..............h..t.....................................................p.......h..t..................t.h..............................................................................t.t..h..t..t.t..h..pt.......................h.....h....pp..........ht.p..hh..t....................................................................................................................................................................t.t...........hp......h..th........E.ht.ht.......htht.......................................................sh..hl.....pG...h..l...Dtl...............................pt.....ssp.............................................hhllD..YK..osph...................st...s.t...................................................ph.....t.......h.....ph.Qhth.Y..t....hslpphh.................................shp.h.t....s..t.....hh.a.h.h...h.t..t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	700	1353	1685
+12541	PF12706	Lactamase_B_2		Beta-lactamase superfamily domain	Bateman A	agb	Jackhmmer:Q189N7_CLOD6	Domain	This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.84	0.71	-4.76	268	12584	2012-10-02 15:46:01	2009-12-16 14:03:32	2	97	4382	48	3955	21211	7413	209.10	16	60.92	CHANGED	pt..lLhDss.s........................................tht.thhtt.t....h........tlctl.......lloH.........sHhDHh....hsh..hhpshhth.t..........................hlhss..................sstptlp.................................................................thsh..................p..........ht.hsht.........................................................................lps....h.sspHtsst.h...............................................ahlp........................................stplhau.uDssh........................................h........tth....................................pp...............hDlhlhssshh......................t....hHhsh........ppulphhp.phssc...p....hlhhHh	..............................................................................................................................................................................................................................................................................h..hLhDss..s..........................................................................h......................plc.t.l..........hl.oH.........hHh..DHh..........hs.h........h..h..t..hh..thhsp.................................h.laus........................................ts.s..t...p.h..lp.............................................................................................................................................t.th....................................................h....h...h..p......t.p.........................hh.p.h...t..s.hp................................................................................................lps..........h....ss..p....H.s.s...s.s..hs.....................................................................................ahlc....................................................................s.sstp..l..h.as..GDoth.........tp............................................................h....pth..............ps..................sDl.hl...h....-s.s..hh.....t......................................htH.hss.........................pp.s...h..p.h...t...p...p....h...t.sp.......p.......llhhHh.......................................................................................................................................................................................................................................................................................................................	0	1384	2524	3317
+12542	PF12707	DUF3804		Protein of unknown function (DUF3804)	Coggill P	pcc	jcsg_3hzp	Family	This family is approximately 130 residues.  Dali search indicates this protein carries a NTF2-fold with a hydrophobic cavity as a structural homologue to 1JB2, 2R4I, 3FSD and 2UX0.  In this hydrophobic cavity, Arg 118 provides the H-bonding force to hold a PEG molecule from crystallisation. The interface interaction suggests that the biomolecule of Swiss:Q46KI2 is a dimer. Two members of the family are annotated as putative EF-Tu domain 2 but there is no match to this family so this is likely to be a false assignment. There are two highly conserved tryptophan residues towards the C-terminal end of the family.	22.50	22.50	23.00	44.60	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.65	0.71	-4.56	5	18	2012-10-03 02:27:24	2009-12-16 16:10:09	2	1	11	1	8	19	129	107.30	53	96.55	CHANGED	SDocpIEuLIpGFAsscc.uSFLlsNsTsDFLAIRPSGNPIoAKGLsGMasSuDLVlEsSELlKIHRLEhhuushuaAlFTLsEpFSYKGspNcDLSTYTsIFKKlDGsWKISWMQRSoGTTDLSTWN	........tl.shlpthss.p..toFhhsNsTsDFLhIRPSGNPIsAcGhttMh.osDlV.EtuElsKIH+hEh.ss.shuhshFTLtppFoYKGs.NcDLsohT.IFKKlcssWKlsWMQRSoGsoDhShWs...	0	1	7	8
+12543	PF12708	Pectate_lyase_3		Pectate lyase superfamily protein	Bateman A	agb	Jackhmmer:Q184L0_CLOD6	Family	This family of proteins possesses a beta helical structure like Pectate lyase.  This family is most closely related to glycosyl hydrolase family 28.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.85	0.70	-4.23	90	2481	2012-10-02 14:50:22	2009-12-16 16:15:15	2	119	1227	26	988	3936	234	234.90	16	41.55	CHANGED	aRN.V+D........aGAcGD..Gso....DDTsAIppAIt............ts..ssusosssAlVYFPsGTYlloss.....................Ih.hhhT.........pllG..sstshssl+...usssas...Ghsllsu.s.hht.........................pssFh.ht.....l+N..hhlDhsshsh.st..............sulcWts.........uQuoolpNl..........hhp........hsss....ssspp.Glah-s.....................uu........sshh.sclhhsGGshG...........h..hhus...........Q................QaohcNhp..........hss.spsuIthhhshs..hshps...hslsssts.....................G..ls	..............................................hs.l.p.-.........a.GAt.GD..........Ghs..........DD.T......t...A.lppAl...............................t.s.ss..ss.ss.h...V..a.h...P...s......G..s....Y.....h...lsps......................................................................................lh.l....h..s....s.s.....................................................p.l.....h.G.......s....s...h..........s..................s...h...l...t.......................s..s...s..t...h.t........................t....h..t....h.h.t.s...p....t...............................................................................................................................................................................................................lps.........hhh....s..h.s..sh...............................................................s.hpht.......................................................................sps....s.t..l.ts...l..........h....................................h.......................................s..............t...........................s...h.hpt.........................................................................................h........s....................s.....................................................................p...........................................................h..htp.........................h...................s..........................................................thh.................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	293	584	826
+12544	PF12709	Kinetocho_Slk19		Central kinetochore-associated	Coggill P	pcc	manual	Family	This is a family of proteins integrally involved in the central kinetochore. Slk19 is a yeast member and it may play an important role in the timing of nuclear migration. It may also participate, directly or indirectly, in the maintenance of centromeric tensile strength during mitotic stagnation, for instance during activation of checkpoint controls, when cells need to preserve nuclear integrity until cell cycle progression can be resumed [1].	23.00	23.00	23.80	23.80	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.16	0.72	-3.91	14	100	2009-12-17 14:51:34	2009-12-17 14:51:34	2	2	99	0	76	98	0	82.20	38	10.97	CHANGED	shpcphpppcp-sscplphlA-DLYsQYSSKHEpKVphLKKuYEs+apc+lcclphcspslpcEl-pLcspLp.ERcEKppLlplL-	............tt....phppss+EVpcAVE+VARELHsLYKuKHEoK..VsAL...KKSYEsR...WEK+l+-lcpclcshpcEsEcL+pph...............t................	0	11	35	63
+12545	PF12710	HAD		haloacid dehalogenase-like hydrolase	Bateman A	agb	Jackhmmer:Q18AI1_CLOD6	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.83	0.71	-4.14	272	9618	2012-10-03 04:19:28	2009-12-17 17:10:43	2	102	3541	13	3687	38047	3600	244.60	16	47.47	CHANGED	shFDhDuTL.........hsss..h.............................hhhhhtth..........................hhh............................................................................................................................................hsth...........thhch..hh..............................tthtshttp...hhp..tht........................................................................pshh.................phl...t...............ppt....Gtp..lhllous.........p.....hhcsh............ht....thshst..llusph.....................................................................................h.....ttth...ssp.htt..........tKhp.....tlpph..................................................hhhGD..uh.s..Dlshlp	..................................................................................................................................................................................................................................................................................................................................................................................................................................................hhhDhDuTL..........................hppc.......h..................................h...hsth.h..h..................................h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.h..pt...............sht.p.....ht....................................................tt.h..t...s.h....t..t.t.......hhp......tht................................................................................................................................................................hhtshh...............................chl...........pp..................lp..pt........Ghc.........lhll....oGu.................hp........hspsl.......................................sp..............phs.l..s...t...............h.h..us.ph.......t..........................................................................................................................................................................................................................................................................................................................................h.h.t.sch......ssp.....................t.Ksp...........hlpch............................................................th.thttshuhG.D..us.N..Dlshl......................................................................................................................................................................................................	0	1113	2065	2970
+12546	PF12711	Kinesin-relat_1		Kinesin motor	Coggill P	pcc	manual	Domain	This family is closely related to Kinesin-related, Pfam:PF06548.	26.90	26.90	30.40	30.40	26.80	25.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.79	0.72	-3.58	20	117	2012-10-05 12:31:09	2009-12-18 13:10:42	2	3	54	0	61	122	0	86.50	42	5.74	CHANGED	RE-KIpRLEsLhsGsLss-salh-Es..psLpcEIclL+ppl-+sPEloRaAlENhRLpEpl+phppFh.-pGEREhllpElspL+spL	.......REDcItRLE+Ltcpuhsu.hsppp-p...ppL+-EIphLR-QlE+pP+ls+YAhENppLREEs+RL+thpsVcpspEh.spplupLEctF.....................	0	11	24	38
+12547	PF12712	DUF3805		Domain of unknown function (DUF3805)	Coggill P	pcc	JCSG_target_3hlz	Domain	This family represent the N-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1tui, also of unknown function. The domain carries four conserved tryptophan residues.	21.80	21.80	21.80	21.90	21.30	16.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.89	0.71	-4.43	6	50	2009-12-18 14:33:49	2009-12-18 13:56:41	2	2	50	2	7	40	1	153.60	68	57.55	CHANGED	M...KKaISPGuWFShpYPuDWsEFEDuEsSFLFYNP-+WTGNFRISAYK.....ssussYGp-slcpEL+ENsSApLVKVGcW-CAYSpEhFQEEGsaYTSHlWVTGt-sluhECSFTVPKGEsl+tAEcIIASLclRK-GsKYPtEIIPlRl.EIhpIN	...hQG.KKFISPGuWFSMpYPuDWsEFE.DGEGSFLFYNP-p.WTGNFRISAaK......GsAsYGK-sl+QELKENsSAoLVKVGph-CAYSKEMFpEEGsYYTSHLWlTGh--lAFECSFTVsKGssVcEAE-lIAoLElRKEGpKYPAElIPlRLSEIYpIN....................................................................	0	1	5	7
+12548	PF12713	DUF3806		Domain of unknown function (DUF3806)	Coggill P	pcc	JCSG_target_3hlz	Domain	This family represent the C-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1ma7 whose C-terminal domain is a phage integrase, Pfam:PF00589.	20.70	20.70	21.40	20.80	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.62	0.72	-4.52	25	109	2009-12-18 14:36:53	2009-12-18 14:36:53	2	2	100	2	30	98	23	85.00	28	39.15	CHANGED	pDlsslQpllDpuhlssccpp......s.hpuhGlslGslLssEh.tGh-WhsltDstscs.uLphtsoc.thlh..Phshlhc+hcsGptsslschY	.........................DlpplQpll-puthssccpc......t.htuhGlslGslLssEh..Gh-WhslhDsttcs.sLpht..ssp.hhl...Phpllhp+lcsGp.sslhp.a.............	0	10	26	30
+12549	PF12714	TILa		TILa domain	Bashton M, Bateman A	pcc	Pfam-B_897 (release 5.2)	Domain	This cysteine rich domain occurs along side the TIL Pfam:PF01826 domain and is likely to be a distantly related relative.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.61	0.72	-4.21	42	957	2012-10-01 23:42:56	2009-12-18 15:44:45	2	141	60	0	540	797	0	55.90	33	10.67	CHANGED	GCpDspGshhPsGcoWhoss.CoppCsC.ssGtIpCpsapCsssohCp.p..sGspsCt	.............GCh.hpG.p.Y.a.s..G.c.p.ah...s.ss..CsppCpC.t.s.s.u.tl....pCps..t.p.Csssp.h.Cplp..sGhhsCh..............	0	58	113	320
+12550	PF12715	Abhydrolase_7		Abhydrolase family	Coggill P	pcc	jcsg_3g8y	Family	This is a family of probable bacterial abhydrolases.	20.70	20.70	20.70	20.70	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.29	0.70	-5.54	4	102	2012-10-03 11:45:05	2009-12-22 11:09:37	2	2	85	7	21	133	18	320.60	36	84.06	CHANGED	ppapPp-Hsll+SsRsDGRaLSSYGlVHsMLcchcPphAFpsDMSs+EFspWQctVR+AMpEIMKFPp.pcp.PuPVClKT.pREGYRLEKWEaYPhPcsVSTFLVLlPDsl..ppPVPulLCIPGSGtoKEGLAGEPGlssKLs-.cYpsP.KloMAhNhVKpGYlAVAVDNsAAGEAuDLE+YstGpNYDYDllSRFLLEhGWSaLGYsSYLDMQVLsWMKopsaIRKDRIVlSGFSLGTEPMMVLGsLDssIYAFVYNDFLCQTQERAhVMThPDKpGpRsFPNSIRHLIPsFW+pFNFPDIVAuLAPRPlIhTEGGLDRDFpLlppAYthuGtP-NschaHYPKFADPspRKcl-pLPEGLDRcpYFchVNVDsPsHYFKsELVIPWL+Kl	..................................................................................................................hhtsh...........................................................ppatpWRpp...s.Rchlp.p.hh........h.hP..s.ssh....s.....a...ssch........l..c.pp...c.Rs....u.Y.hsE.Klth.slo..sc..SR..VsuhLLsPcth..........cGPaP..A..llhL..H..G.p....s..h....s....K....EK....hl............t.....h.G.s....s..sc...lss.......sh.sct.........tph..........hG..........c.p.........LA.....K+G....YVVlulD....u.luWG-.....R.....G....s...h.....p.....h.....pp..t................p..sLAsshh.....p.....LG.pShuGhh....uY-....D.M.R.slDFhsoLPpVD+cRIGlhGFSMG.uaR.uW.LAALsDpl.tAss....hhuahsph.....thhhhsssps....htu.tsuhhhLhPGlhp.phDaPDlASlAAPRPhLhh....N......G.........u.....cD.........+.........L.....F..........h..V....c..pAYt.......................................................................shthhhttt...............................................................................	0	4	14	17
+12551	PF12716	Apq12		Nuclear pore assembly and biogenesis	Wood V, Coggill P	pcc	Wood V	Family	This is a family of conserved fungal proteins involved in nuclear pore assembly [1]. Apq12 is an integral membrane protein of the nuclear envelope (NE) and endoplasmic reticulum. Its absence leads to a partial block in mRNA export and cold-sensitive defects in the growth and localisation of a subset of nucleoporins, particularly those asymmetrically localised to the cytoplasmic fibrils [2]. The defects in nuclear pore assembly appear to be due to defects in regulating membrane fluidity [3].	25.00	25.00	26.60	25.90	22.80	21.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.53	0.72	-4.27	34	86	2009-12-22 13:18:28	2009-12-22 11:51:49	2	1	85	0	63	74	0	52.00	27	30.96	CHANGED	hPslssllhlllllalsh+llchhhRhhhhhlhhll+lsaassllshuhhlYhp	....Pclssllhlllhlalsh+lLshhhRhhhhalhhll+lhaassllssshhlYhR...	0	11	31	52
+12552	PF12717	Cnd1		non-SMC mitotic condensation complex subunit 1	Coggill P	pcc	Pfam-B_410 (release 24.0)	Family	The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.06	0.71	-4.43	77	571	2012-10-11 20:01:02	2009-12-23 16:26:08	2	33	298	0	412	1562	22	172.30	27	14.18	CHANGED	sshlRsNhllsluDLshRassll-.a....sstlh......ppLp.....Dp..s.......................shVR+sslhsLo+Llhp-hlKh+Gpl.hchhhsL...tDssppIpshAchhhp-ltp+....s.shl....hNhhs-hls....tLsp..ttt............................hsppphpplhpallshlst..........-+ppcsls-Klst+httsp...............................................stp.hpclhhhLshhp	.................................................................................hlRsNhlluluDlslpa..s.sll....-.h.....sstlh......tpLp...........Dp..s..................................................................V..R+...s...slhsl.......op....L.....I...h....p....s..h.....l..K....l.K....G...p.l........s.c.hs.t.s..............L......Ds..spc...I.sshAc..hhFscLs..pK........sssl...........................aNt...h.s-.hls....pLss..................................................................................................................................thpccphppIhcaL..l..p.h..lp..............................-.c.pt.pl.s..pKlstch.ts..........................................................stp.hpDhhhhLs.h.....................................................................................................................................................................	0	152	231	339
+12553	PF12718	Tropomyosin_1		Tropomyosin like	Coggill P	pcc	manual	Family	This family is a set of eukaryotic tropomyosins. Within the yeast Tmp1 and Tmp2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpmlp spans five.  Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis [1]. The family also contains higher eukaryote Tmp3 members.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.97	0.71	-4.34	41	292	2012-10-03 05:16:33	2009-12-23 16:36:48	2	14	225	0	176	1155	1	117.90	33	58.23	CHANGED	KhpsLKlEs-sAt-+sEphcpchKphEpcshcpEpElpSLp+KsptLEs-l-clEppLp-s+sth--uppttopsE....uLsR+lQLLEEELEcu-cpL...+ETsEKLccs-hpA-chERphpsLEpcppp.EcKhE-hpcphccu+t	...................................KhptL+l-t-su.p+.s-phctchKphEpc.sh.........p....p...Ep..ElpuLp+K...phlEsEl-...Kl.c.p....pLp-scpthc.p....s...pp..t..t.sps-...........shp.++.p.lE....pph-psc....tpl.......pps.p.clppsphtutp.t..Rt..h..hp...p.....t...-t+..t.......t........................................................................	0	56	93	142
+12554	PF12719	Cnd3		Nuclear condensing complex subunits, C-term domain	Wood V, Coggill P	pcc	Pfam-B_484 (release 24.0)	Family	The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.	25.80	25.80	25.80	26.60	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.86	0.70	-5.43	57	330	2012-10-11 20:01:02	2009-12-23 16:51:05	2	9	263	0	236	335	0	307.10	23	30.42	CHANGED	h+CLtlspthLpplp.tslppshpl...sllssLlh...Pulpsp-s.slRchulcCLGLhsLLsc..........plAp-sh.lhhpth.pp.........s.ssplphhAlpslhDllhhaGhphhsspsp........................................stshslhclhh+hLcss......psc......lpshusEGLsKLhLsshlss........................................................spllpsLlltYFsPpopssp.................tLpQsLuhFhPlYsaSphpp..Q..pphtpshhsslhplhph.tch.........ssts.lp...........ssplhphllchTDscphsshsptt...................ttssH.tlu....hplLptl.......t..pscc...p+hlhphLs+Lhls..ps.s...ppphpth	...............................................................+CLhlstthLpphp...ts.hp.shsh........sllpsLllPulpstcs.slRphulhCLGlssLlsc......................phApcp.hsl.hhp..hh..pp.........s..ptslph.sA.....Lpsl..hDllh.ha...G.....hp.hhssptt..........................................................................................................s.ttsllcl.hhch...Lcsp..........ssc....................lpshuscGluKLhLsshlss........................................................sclLp.pL.llh.aFsP..to...pp.s...........................p.L+QsLu.hFhPsas...........h..u.....ph......pp.Q.........pthp..cshlss.lps.lhss.ts....................ss.s.ls...........hsplsphllchTcspths..s.sptt.................................................t.ssH.slu....hclhppl............ht...spt..tt+hhhphLspL.ls...t........th......................................................................................................................................	0	86	133	200
+12555	PF12720	DUF3807		Protein of unknown function (DUF3807)	Wood V, Coggill P	pcc	Pfam-B_6113	Family	This is a family of conserved fungal proteins of unknown function.	25.00	25.00	30.50	59.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.46	0.71	-4.10	19	65	2010-01-04 17:41:02	2010-01-04 17:41:02	2	2	65	0	54	64	0	172.50	31	78.96	CHANGED	DLpuFpAcHFssps.................sssshst................tppshsE-h............DDsLGYYPDGsKRTLTDEQIpIFRHSEIcuLhRc+chpc.-p....t.............hp.ttchps..t..s..tp.tt......................ttpppssptpc+ptpstpcpsspps...........h.ss.ttstssLcYs-csstttpt.......psssshuRRllS..........Y-D	...................................DL.sFaspHFsspsh.................................ptp.ttt................tpsshpE-.t...........DDuLGYYPDGVKRTLTDEQIpIFRHSEIc..uLhRp+chpcppp................................tpstspssspt.pts..stssptpttps............................sppppstppppKp.ppshpcppspts.........tpphsssptuh...ssL.-hsppt...............sp..tR+hls................................................................................................................................	0	8	23	41
+12556	PF12721	RHIM		RIP homotypic interaction motif	Coggill P	pcc	Masci AM	Family	RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins [1]. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI [2].	17.20	5.30	17.20	5.30	17.10	5.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.52	0.72	-3.55	28	243	2010-01-08 12:49:32	2010-01-08 12:49:32	2	18	70	0	89	231	2	48.60	23	10.48	CHANGED	PsPpsss.sssssspss....................ssssshslsIp.sssulQIGspNhMslp	.........................................................................................................s...................................tss...ltIp..su.pslQIGssNhMph.......	2	23	32	39
+12557	PF12722	Hid1		High-temperature-induced dauer-formation protein	KOGs, Finn RD, Coggill PC	pcc	KOGs (KOG2226)	Family	Hid1 (high-temperature-induced dauer-formation protein 1) represents proteins of approximately 800 residues long and is conserved from fungi to humans. It contains up to seven potential transmembrane domains separated by regions of low complexity. Functionally it might be involved in vesicle secretion or be an inter-cellular signalling protein or be a novel insulin receptor [1].	20.50	20.00	20.70	20.00	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	895	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.63	0.70	-6.87	28	348	2012-10-01 19:21:38	2010-01-08 16:35:52	2	7	227	0	260	575	7	599.10	26	91.93	CHANGED	MGso-SKLs..F+pulhcLspp.............................................pth..ss...............--s...aWppFW....chspospDlFs.Lloss-IRplRDps.sNltoLlhtlsp+lhhhspp.ssh..............shs.pp..plLNClRlLTRlLPalaE....tppWcs..taFWusp.c.hh..t...............................tt.psspPLAtpLlcuLlDLLFhssFTlssst..........pshspspa.IWEuGVGsssshsp.......stch-uNRsElL+LLLTlhScshYhsss.......sspss+alsahsosss+p.lLsLhsSLLNsss+Yssss....hslPY.splhapDs+p..............................hLVphsL................QlLllhlsashssssph...................................................shscNhahpYLu+lHRcpDhpFllcGhs+lLppPlp...........................................................................................pohlPsss+.lpa..t.EhLhLhWchhphNK+Fhpalh-opcshDlllhhlYalhpa+sssu+hG....................................ll+hssalLLhLSu..-+sFsh+LNcsass........ppLP.........h+lsshsG.....TauDalIl.hppll.............sosptp.p.lhssLlpllhNlsPY.......................................hpsLShsuuspllpLlsshSoPtFLhu................................sssNacLLthLL-shNshlpapFcs................NtpLlYullRp+clacpLtshsh-.upp.hptpsp.............p.............................................t...tshtsspppsstps.ptss..pssps.t.sphs.p.ssshshssspsptsp..cspss.ssss....................t.s.t.pt.p.tsttp.sthp.thspppsspp.p.sssh..psptpatsossWhcSWtscL..sLpoIhpll....pslhspl.phshppuhss-u.hl.....chhpcsplpulls.......sPpPlpl+paphsshohtWacolhWGhIaspph..............................................................................................................t............................................................................................ssslWssTclKLFcl	.................................................................................................................................................................h..tL.t............................................................................................................................s........................sp.........hatthh.....t...p.p-lht.hhs.tpl+.ht.............ptt...NhtsLhhhhs.plh.hh..pp........................................p....p.....hlNs.Rl..Ls+llPhhh.....E..........thpt..................hhWt..........................................................................................................................t..sLuppLl.slhcLLFh.sF.....Tl.......................................................t.tp....h.lWpsG..luhsts................s..ht.sR...hElL+LLlshh.upshY.s.t................................s.hl.hhss.............sp......hhshhsSllNssh....ths.ss...................tls..a..s.hh.h..t..s.pp..............................................................hl..sh................phL.......h.hl.a...........................................................................tNhhh.a.hsp.lp+.t...Dhp.....hl.....hpuh..plht.sh...............................................................................................thhst......p...h...h.phhh.hhaphhphNppFh.hh.hp...t.s.c....hll...hl..h..hh...ctp..t.p.s.....................................................................lhphs.all.hLSs....c.th...h.p....L.p..hp..........plP.....hc..ls..h..s.......................oat.Dhhl.h.hhp.ll.........................hss......t...............l..h..shhhthl...N..l.sh.............................................hptlu..ss..plhpLhtthSs..a..Lhs......................................................................................s..ph.....hl..l..Lc.hsshlth..phpt....................s..Llasll..+ppphhp..tlts..h..p.st.........t..................................................................................................................................................................................................t............t.................t..t............................................................................................................t..............................t.........................................t.........th..s..a.............h.sW..ph..sLphlh.pll.....p.l...l.....t.....t.t....t.............t................h..h.........................sh..t...hp...............s..h.hhWh.thhWu.la.tt...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	101	146	222
+12558	PF12723	DUF3809		Protein of unknown function (DUF3809)	Bateman A	agb	Jackhmmer:NP_295729.1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in Deinococci bacteria. Proteins in this family are typically between 117 and 157 amino acids in length.	25.00	25.00	42.00	73.70	23.40	17.00	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.94	0.71	-4.28	6	19	2010-01-08 17:04:36	2010-01-08 17:04:36	2	1	19	2	13	19	1	127.90	38	90.81	CHANGED	oFsLphPus.ApuLs....Pthshuth..h+sLpt-uEtlcGELVspsPlLGElDLPFpSRLphpspGt....pLhPhsLsGE.s..WlEVuGpupssEsG.lsaphphRsHLsLPpuEsWGGtAFc+MlcAAhuRTLERVhppL	........................................shs.h...h-Lch....-upplcGpLhtpsPlLGElcLPFtSRL....-Gt....pLpPlPL...ss..hlEVpGpucss....u.....tu....lththclcl+LpLPpGcsWGtRAFt+hlcAhFtRsLERsLst....	0	3	8	13
+12559	PF12724	Flavodoxin_5		Flavodoxin domain	Bateman A	agb	Jackhmmer:Q186N5_CLOD6	Domain	This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.72	0.71	-4.19	70	1747	2012-10-03 05:08:30	2010-01-11 11:17:35	2	13	1363	0	401	2543	510	137.00	25	68.21	CHANGED	LIlYuSpcGpT+cIup...hlu...pplptt....sphsslps..h...t.th..slspaDp..VllGAul+hG+apstlhpFlppa...tstLsst.suhFsVsLs........uccspc.........h...hc.+h......l.p..sh..a..p.....PphhtlFu..GuL.pYs+Ysah-+hhlphI.hph...stup...s-ss	.............................................lIlYu..o.p..p..G.pT+clAp...hl...A....p...pLpp.................sths.....clps.......s..............................p.......p....................s......h.p..sY.......Dp.....lllG.u.u.l.h.h..G...+.h..p...s..t..h..p.c.Fl.c.+.p.....t.s.p.L..s..s.....h...s.u..h..as.l..shs............upc.s.pc..............................h...hp.ch......l.p...p.....h.....p...........st..hthhs..Gtl...h..phthhc+hhhphh.ht...tt.....t................................................................................................	0	140	253	344
+12560	PF12725	DUF3810		Protein of unknown function (DUF3810)	Bateman A	agb	Jackhmmer:Q185R6_CLOD6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 333 and 377 amino acids in length. There is a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterised family of peptidase enzymes.	26.10	26.10	26.30	61.80	25.40	26.00	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.94	0.70	-5.53	60	206	2012-10-03 04:41:15	2010-01-11 13:16:19	2	1	203	0	62	211	151	314.90	30	87.94	CHANGED	hYSpslYPhluthlphlhuhhPFSlGD..lhhhl..hllhllhhlhhthhphhpphtph...............h.hphhthls....llYhhFhlhWGlNYaRhshtpph..........slphtp.Yos-cLhphsptllppsNphptplsp..........spshhhths..s...pclhcpsh.puYpplsppashhp..hp.hspsKsslhShhlShhGlsGhhsPFTsEAplNsplsshphPhThsHElAH.lGaupEsEANFIuYLsshpsss.ha+YSGahhuLhYslspltc.hs.ctapclh.pplssslhc.shppsppaWppa.cs.sl......spltphha-tYLKuNsQpsGhcSYuchVsLLlu	.............hYupslYPhluthlshhsuhhP.FSlG-.lhhhl....hllhll.hah.hht.hh.phhpphpph......................lhphhthls....hlYhhF.....hlhWGlNYhRhshhpph..............................pl.phtt......ao......s-cltphspphlpphNphtsplsp............ssp..h..............ppltpcsh.puYpplsppashhp...sp..hspsKsh.lhS.lhShhGlsGhhsPFTsEuslNspl.shphPhThsHElAH.hGaupEsEANFluYlsCppusshth+YSGYhhsLtYslssltc.hst-tapclh.pplpst........lhc..shp.ppptaWppaps..hl.........spl.tshhactYLKuNp.psGhcoYuchVsLLls...........................................................	0	31	54	59
+12561	PF12726	SEN1_N		SEN1 N terminal	Mistry J, Wood V	jm14	Pfam-B_2547 (release 24.0)	Domain	This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes [2]. The N terminal of SEN1, unlike the C terminal, is not required for growth [1].	20.60	20.60	21.70	21.70	19.40	18.90	hmmbuild  -o /dev/null HMM SEED	727	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-13.27	0.70	-6.48	34	152	2010-01-11 14:18:12	2010-01-11 14:18:12	2	9	140	0	119	164	0	637.60	21	33.42	CHANGED	Wlpp+hsppLpsCspClpsatpuKsphhpphh..cphstpp.lppFhphlspW-hpplhtsLcphppphpss..s..p.s........h.hulaEsLsssshL+sssthcth...FsthFchl.sppphh...h.........pphl.PGhhhhLF-s.ss..ppppWApphhpphtpp...hsppphs.slhptlshtlhpl...........s..ts.hs.shhtp.......FWpshthll..phlsp-hlppthps............htlps.lh+lhhsHLtss....stsLthlLcsLphlLc+hsssF.Ws.thpsho.p.........sll-plFssstFsphLhcsppss.hpppt................hpshh...uWhhsFhpSLsssp.p.................psscpls.hLlpphpp.pp.sp.......t+tsshtsuhshLlpslhs....hpcpcps.......shpsslhsls-shshlssth........shh.sssth..h.tpstslsphshpllppslsh.DhhtLppppttLhps........sth.sss....phhs.......lWpplhpthh.psshs...LuptlLtuht..........slsul.hh........spp..............phsstpppaNphhpphtphhspll............p+lu-h....sPspLpplhs.cp..ssspulhSsl.hSss.plhpAAhsllppsh.s.ssuRhEulpclLppphssslpulshslpplpphcs....apssP+.hl+shhDllssLsDs.sGlL.....pspphht....pssttplt....paWchtWphLshIFppThtWusp..actp.hh-FsRDTL-huchLh-paplhsssls.t.sss...........pssps.............lhpsshpshpshlhWLRLsDc.LLsssVpL	.......................................................................hhp+hpt.LppCs.Cltpaapu+tthhpphh...cphsppp.lpph.phlsph-hpRlhpsLppspthhpph.s.ptt.....................................thhhul.aEsLss.thLppsp.hpth...Fs.thFphlpsppphh..h.........................pphl..PuhhhhLF-t..st........ppppWAhp.hppht.p......hst.pp.h.......s.slhp.l..tlhth.........s...tt.hs.t...hltp............................hWpuhthll..phhsp-.lhpplps.............htlp...s..hhcl.hhsHLthp....s.sL...lL.....p...slphhLc+hsppF.Ws..shtshssp..........sll-.lhtsstapthLhp..psp...pt................................................................h.shh...uWh.sahpSLptsp..p.................psschlhh.Lhpp.hpp..t..t.......sphtChhtuhshLhpslhs....hhptpts...........phpsthhhhsph..h.thltp.h........................phh..ss.h.......t.tlst.shtlltpslth.-ht.htpph.hlhpt....................sh.............ph.t.lWptlhpth...pssht.....LupthLhuhh.............slhul.hh.spt....................tttppaNthhtphtphhspll............t+hu-h..........psppLpplhp.st..ps.tuhhuhl.hssp.phhpuAhplltth..s...tuRh-ulpthlpp.ht.sh.uhshshppl.phth.......atshs+.hl+hhhDllpsLs-s.sGhL.....pstph......ptphhtl........phWp..WphlshlappT.tWt.h..hcht.h.pFsRDshphuc.Lhsphtlhtsslt..t.t.t..................................s.tpp................lltsshtshpshhhWLRLpDp.Lhpshlt...................................................................................................	0	35	71	106
+12562	PF12727	PBP_like		PBP superfamily domain	Bateman A	agb	Jackhmmer:Q18A58_CLOD6	Family	This family belongs to the periplasmic binding domain superfamily. It is often associated with a helix-turn-helix domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.88	0.71	-5.35	186	867	2012-10-03 15:33:52	2010-01-12 08:16:29	2	14	708	0	360	5148	918	188.80	29	45.74	CHANGED	spthtpt..ss.hp..lt..hthsGShsGLtuLt.cGcsclAuhHL..h.......................cs.css..p..........aNhs.hl.......pch.h.ssh.s.hsl.....lphspRppGlhlttG...NPt......s...............................lpshpDL....sc....tslphlNRpp.GuGoRhLlDphL....pp.t....slss......................splpGYsppttoH.hsV..........................AssVssGp...ADsG.............l.G.l......pss.....At..ph.uLcFl.......Pl.sp...........EcYDLll.+phh.pc..stlptllphlp	.............................................................................................................................t............t..ht..lt..ht.....a.hGShsu.Lh.s.Lt....p....G....c....s....c.l.....A...uh.H......L...h...........................................c.s..cs..s..p.........................hN..hs..hl....................c.ch....l.sst....s..hsl........................lph.h.......p....Rp..p..G.l....h....Vt.pG....NPp...................p........................................................................Ips....h...t...D.L.............sc................ssl.+...aV..N.Rpp....G..S..G..o.R....h.Ll.D.p.h...L........pt..t........slss..................................pp.l..s.G..Y.p.....p..p...t...h........o....H..hu....V......................................................Ast.Vu.sGp.......A.D..l.G..............................................l...G....l............c.s..s.......At.......ph.....u...L...-...F..l........................P..l.tc............................................EpY...D.l.ll...+.s...t.h....p..c...h.lptllphh.t.......................................................................................................................................	0	130	258	307
+12563	PF12728	HTH_17		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q18A58_CLOD6	Domain	This domain is a DNA-binding helix-turn-helix domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.41	0.72	-3.71	461	7911	2012-10-04 14:01:12	2010-01-12 09:58:31	2	67	2491	0	2062	7447	1041	50.90	22	40.39	CHANGED	hlospEsA.chLs.l..uppo.lh.c.h...h.....c....pu..pl.sh.......t......t......hthpcp-lppalpppp	...................hospEsA.chLs..l.....SppT.lh.c.h.......h.........p.............pG.....pl.sh..............+.....hGpp....hhhpps-lppalpt..t..................................	0	792	1556	1892
+12564	PF12729	4HB_MCP_1	4HB_MCP_2;	Four helix bundle sensory module for signal transduction	Coggill P	pcc	Ulrich L	Family	This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.64	0.71	-4.93	65	4710	2012-10-02 01:04:29	2010-01-12 14:21:04	2	84	1259	0	1579	4943	147	176.50	14	30.92	CHANGED	sh..plpsKLhhh..hhlhslhhhllG..hlGhhshpphspshpshYpcpLlslphlsplcsshtphcstlhcllhs.p-psc...ppplhppl.pphppchsphhppYcpshhssc.E..+c.hhspacpphppY.pptpppllsLsppsphc.....cAhphhpspst..shhpphhpslpcLhphstphAcpttppspsph	................................................................h.pltp+Lh..hu...Fu.llhll.hl.hlu...shul..h..p...l..sp...ls..ssh...p..pl...h....p...s...p...h...s..sh....phh...s...p....lp...s...s..h....t....p....h..p...hs......h...h...p.............h....l......h....s....p.....s....s...pp..............hp...p....h.t...pp...l....pp....t.....p.....p....p....hp...p....t...h........p....p.....h......p......p.......h........h..........h.....s......s...p.....-......cp...hh.p..p..h.p...pt...h....p.p.a...h...s.....h...h....p..p.....h...h...p.....h..h.....p....p.....s.p..h...p........................p.A..h...t..h.......h.h...s...p.h.t......shh...p...t.h...t..p.tl...p.p...l.h.p.h...pt...p.stt..............................................................................................	0	404	885	1233
+12565	PF12730	ABC2_membrane_4		ABC-2 family transporter protein	Bateman A	agb	Jackhmmer:Q18D57_CLOD6	Family	This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.05	0.70	-5.20	293	7890	2012-10-03 10:13:34	2010-01-13 08:24:29	2	18	2165	0	1696	13517	1344	250.10	12	82.58	CHANGED	psEhhK.h...t...+...s.t..hh....hl.hhlhsll....hsh..hhh......h..hh.t...........................................................................................................................h...t....tt..h.......t....hh..........h..........h...............................................t....hhhh..........hhhs..l...hlsl.hs.uh.hh..s.tEh........psst........hp....hhhstshs+tplhhuK....hlshhl.h.hh....l.hh.ll.hhhhh.hl.h..shl.hs....h.........t.s.h.sh.s.................................hht..h.h...hhhhhh.s...l.hh.h.hh.......hhhl..h.h.....l......uh....hhc.....s....h.hhs...ls...l.sl.h....hh..h...hsh..hh........st..h.h.......................hhh.sh..s......................hthl..h.......h..th..........h.......t.s....h........h.t........s......h..s..h..........hh.s....lh.hh...hhhhllhhh	.......................................................................................................................................................................................................................................................................................................................................-hh+.h.....h...p...p.h..hh....h.h...h..h..h..h..h..h.l.........h.s.h...hhh.........h.h.h..t........................................................................................................................................................................................................................................................................................................h...........tt...h........t.....hh.............................h..........................................................................................................................hhhh...........hhhh.......l......h.hsl.....hs.....s..h.....h...h........s...pEh.............pp.ss...........hp......hhhs..t.s.h.s...+..h.ph.hhuK.......hl...s..h...hh.h..sh......l...hh....l...l....h.h....h.h.s.....h.l..h....s.h.l..h.t...h...........t..s.h.shs.......................................................................h.ht...h...h...h...h..h..h...h.h..h....h...lh..h..hh..................hhhl......hh.........l..........uh......hhc..........s.............thhs.........lh........l.sl..h...........h.h..l......hsh....hh..........sh..h.....................................................hhh..sh.t...................h.hh.....................h....t............h..................................................................................h......h.............................hh......hh..hh...hhhhh....h.....................................................................................................................	0	700	1290	1510
+12566	PF12731	Mating_N		Mating-type protein beta 1	Coggill P	pcc	Pfam-B_4610 (release 8.0)	Family	This domain is found in some fungi and is the C-terminus of a homeodomain-containing transcription factor protein involved in mating.	21.30	21.30	21.50	22.00	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.76	0.72	-4.11	24	64	2010-01-13 13:49:11	2010-01-13 13:49:11	2	4	19	0	5	61	0	90.90	21	18.04	CHANGED	hs.ts......DpplppsLsslcpcFhuuLcs-st.s.LssFhouaspFcshlpShpspLss-TlshlhsFussluslosshl-hpupppsht.cchss	.........hs.........t.DtpltpsLpshcps.alsuLpssst.s.lpsFhsphpp.h..psthp..u.t..p.s..pL...sspThphl.hsFushltslosshlclcsppsplp.sch..t.........	0	5	5	5
+12567	PF12732	YtxH		YtxH-like protein	Bateman A	agb	Jackhmmer:Q18C91_CLOD6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterised.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.56	0.72	-3.61	235	1575	2010-01-13 15:49:26	2010-01-13 15:49:26	2	9	1168	0	352	993	72	104.10	22	81.49	CHANGED	hlhuhllGuslGussuLLhAPcsG+-sRcclpcpsp....chtcphpch.t.....................................lppphpp...........................................spcpspchhsc	........lhuhlhGussGAssuLLhA....P.cpG+-hRpclpcthc.............chpcps..pchp.pp.sppp...............................................................................................hpcphpp.........h.tt....................................hppthp.....ptttt.........................................................................................................	0	141	267	317
+12568	PF12733	Cadherin-like		Cadherin-like beta sandwich domain	Aravind L, Coggill P	pcc	Aravind L	Domain	This domain is found in several bacterial, metazoan and chlorophyte algal proteins.  A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.	22.10	22.10	22.20	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.67	0.72	-3.70	218	661	2012-10-03 16:25:20	2010-01-25 14:57:29	2	169	264	0	277	708	92	93.00	22	12.69	CHANGED	LssLsl......................s.s......Fs..ss..sts.Ys.s..sVsp...sss.s..lslssss.p..............................lplsG...t.........................s...slsL..s............G.ss...lslpV......sup.......sG......s...........................s..pp.Ys.lsl....pRt	.....................................................................ltlp................s.s......Fs...ss....tts.Ys.s..pVst...sss.s....lslsspst....................sss...sp.l..p.l..sG..hts............................s..tslsL...s............GtNp....lslpV.........sup.............cG......s.............................s...pp.Ys.lslpR.................	0	145	224	258
+12569	PF12734	CYSTM		Cysteine-rich TM module stress tolerance	Aravind L, Coggill P	pcc	[1]	Family	The members of this family are short cysteine-rich membrane proteins that most probably dimerise together to form a transmembrane sulfhydryl-lined pore. The CYSTM module is always present at the extreme C-terminus of the protein in which it is present. Furthermore, like the yeast prototypes, the majority of the proteins also possess a proline/glutamine-rich segment upstream of the CYSTM module that is likely to form a polar, disordered head in the cytoplasm. The presence of an atypical well-conserved acidic residue at the C-terminal end of the TM helix suggests that this might interact with a positively charged moiety in the lipid head group. Consistently across the eukaryotes, the different versions of the CYSTM module appear to have roles in stress-response or stress-tolerance, and, more specifically, in resistance to deleterious substances, implying that thes might be general functions of the whole family.	21.90	21.90	22.00	22.10	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.59	0.72	-3.88	88	306	2010-02-01 16:08:54	2010-02-01 16:08:54	2	4	97	0	189	281	0	50.20	33	55.31	CHANGED	s................P.ssYsp.......................t....tppp.sss....................hhpGCLAALCCCClh-hsh	....................................P..uYsp................................ts....sppp.tsu..........................hlpGClAAL...CCCCll-tCh......	2	33	98	150
+12570	PF12735	Trs65		TRAPP trafficking subunit Trs65	Coggill P	pcc	manual	Family	This family is one of the subunits of the TRAPP Golgi trafficking complex [1]. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II. While both complexes contain the same seven subunits, Bet3p, Bet5p, Trs20p, Trs23p, Trs31p, Trs33p and Trs85p, with TRAPPC human equivalents, TRAPP II has the additional three subunits ,Trs65p, Trs120p and Trs130p [3]. While it has been implicated in cell wall biogenesis and stress response, the role of Trs65 in TRAPP II is supported by the findings that the protein co-localises with Trs130p, and deletion of TRS65 in yeast leads to a conditional lethal phenotype if either one of the other TRAPP II-specific subunits is modified [4]. Furthermore, the trs65 mutant has reduced Ypt31/32p guanine nucleotide exchange, GEF, activity [3].	29.30	29.30	29.40	30.00	28.90	28.50	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.72	0.70	-5.11	38	136	2010-02-01 16:49:17	2010-02-01 16:49:17	2	4	134	0	104	139	0	297.20	24	49.38	CHANGED	cssshhs.......hphshtphslshpsG..plp.hsp...h.....hPlphpspDslohhYKLss..................ss.st.s..................lplplphphh.......tsspspIt.hpWpTtlDFuh.h......P..spslppsspss...o.sh.......ssstssts.h........................................................sshsshtttspstst.ulphoFtGs...sVplGcsFsWpl.llNpSs.........................pshcLslhs.s..................ph...p..t..spsts.t........................spslh.pshhthhpp.st.p..........pssllsLosDl+lGPL.Psssaps-lchlsltsGhh.sL-u....l+lhDhpos-sh..-htclsplls	.............................................................................................................................................................................................................hsshhp.hph.hpph..pLthtsu..plcslsps..h....................thPlpshspDplohhY+Lss......................ss...........................s.tlpIslphp..l.l........s.ssp.splp.hpWpTplDFshsh..........................s..sp.slp.p.sppss...phsh...........sss.ssts.h.s....................................................................................................................................................................................s.ssss.t.htsss.s..hGlphoF.us....sVpsGc.FsWplhllNpSs...........................................................................ps+clslhs.s.................................ppph..tsp..ht.sps.ssst.t.tt......................hspslhs..-Nhlpthp...+psthp.............tstllsLSs.DhRlGPL.Psssats-LchlultsGhh.sl-u....l+llDlsosEth........-ltclsslls............	0	30	59	90
+12571	PF12736	CABIT		Cell-cycle sustaining, positive selection, 	Aravind L, Coggill P	pcc	Aravind L	Domain	The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.	20.30	20.30	20.30	20.40	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.67	0.70	-5.37	28	405	2010-02-01 17:20:35	2010-02-01 17:20:35	2	12	102	0	234	418	0	231.50	21	49.09	CHANGED	lPpll+.lp.puphptst............sphlhlpsstp..hpplh.....Apslpppp......hu.plpIPhsYpGpFchhsp..........FpoVp-l........uphhstplhspcshphp.....................s.t................phhlpp...G-plplh......................ttttctttthhp.......................slhshs.pssc....hlpLPhptcGpF.phhspp........paTlc-llc..phcLPhpVclssss.......sh.....t.hstl+Lhshhp-shllsssltpppps..............hclPhp...hplclhtscs..t.ststhhpthhp..p	......................................................................................sp.hhlpptt.........phhh.......hp..htp..tp..........ph.lP.s.Yt.G..hF+hhsp...............asos.-l........upths...c.lhsh..cshpht................................................phslpt...G-plplh.................................t.t.p.t..hhp............................................C.hh..shp..pppc.........tl.LPh.ptcG..pFs.phtstp..........................t.aolpplhp....hcLP.hsVpls.sts..........h...p.ht..h.t.hph..phh.cshlh..hpsh.p.t.h................hch..t...h..ph...pt.................p...................................................................	0	47	66	127
+12572	PF12737	Mating_C		C-terminal domain of homeodomain 1	Coggill P	pcc	Pfam-B_4610 (release 8.0)	Domain	Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.	22.50	22.10	23.80	23.80	22.40	21.30	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.39	0.70	-5.59	20	42	2010-02-01 17:28:21	2010-02-01 17:28:21	2	4	13	0	7	43	0	402.90	27	65.73	CHANGED	sstlEsEFAuItupAcpLYp-KFspSpLAs+LDsAV+DhTPsLKtplpsc+p+++ppsp.pp..sp+ut+sYPoPEpSPss...uphhhSPsssslp.shspssspss++RcsSh...to-sccpsppssKRsRsssspsp...............p....uLPSPusSsh--Lsp.ssss.sosph.Pstsssss.................osKRKR+LSDu....thPAsKRPp.......RspslSDPhPh..tt.ss.spWhpthh.sssplhhhhslPsPVolhsPDss.........sP.............LDlplasFslh..hs.pssssssPsus...................ssspshsssslssssh.ssssssLD.shS.atsssasss......Lpsss.s..h..shP.s.ss......hsts..sh..........................hsshsssshshosLhspPssssssss....ulhssupso.ssssuLs...puphcAKp+ELcELcA+stALcAElA	..........shlEtpFAsltspAppLYspKFppSpLAs+LDsuV+DMTss.......l+tp.............hpp...c+tc..........ccpptp.pt........t.............p..........+A....t............csYPSPp..tSPsu...sphhhoPs.........s..ss.p.....ht.sts.h.......sp+RtpSh.....ssp.ptpsptssKR.Rp.shppp......................ssttsLPS...PssSt.-p.....s...ss.....ssh...sss.s.................shKRKRpLSDu....thPusKRsp......sRspssSDPhPh...tstpp..pa........sspl..hhslPsPVos.ssDss.........sP.............lDlplas.ashh.phs.psssh.sssut...................................s.pshplsuhsp.s.....s.tsssLD.shs.a.ssshs.s.............................lpssp.......shP.s.os......spts..sh...................................ssshshsslhspssssshsst........sl.s.upss.ssshsls........ppphpAKpccLctLpApstAlpAElu.........................................	0	6	7	7
+12573	PF12738	PTCB-BRCT		twin BRCT domain	Wood V, Coggill P	pcc	Pfam-B_181 (release 24.0)	Family	This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair [1,2].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.90	0.72	-4.11	49	1637	2012-10-02 11:51:29	2010-02-01 17:45:22	2	88	308	12	1119	4819	1157	64.10	25	10.14	CHANGED	lhlslouassp-....RptlpphlpthGupastsL.s+.....psTHLls...tpspGpKYctAppas.ltlVshpW	....................................hlsh.os.h.tspp.......+pplt.phspthGu.......p.h..p..ps..l..sp.........csT.H.L.ls....................tp..s...p......u.....p..K....ac..t...A...p........c......h........s...l..........lVsspW..........................................	1	356	574	889
+12574	PF12739	TRAPPC-Trs85		ER-Golgi trafficking TRAPP I complex 85 kDa subunit	Coggill P	pcc	manual	Family	This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport [1]. Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion [2]. The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2) , Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.	25.20	25.20	25.30	25.40	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.55	0.70	-5.82	60	382	2010-02-01 17:51:56	2010-02-01 17:51:56	2	9	271	0	274	400	4	394.30	22	43.06	CHANGED	sop......s.s...sshpshtphhpphpphs..............P.ahpss..t..hh.halLlaDs....stsshppspplhpph+p.....phGh.psplLpl...............................tsppsh.s.t.........................s.assh.cph.t.t.t........................................................................................................t.tshhlshs-h.psl+shlp-hlspsllPa.........................ME+clphhs-plss.RKGl..ss+hhphs...+..+a...as........susssssssssts.............................................................................t.hYshsSsEttlR+LADhuFhLpDa.chAhosYchl+p..DapsD+AWpah.....AuspEMsu....luhhhss.p.s..............................tpp.hp.hl-s........Ah.sYhp........................................................................hp.....huhR.shllssEl....L...................pshsth.sust.hhchs......sc......pht........................pAllhEpsuhsa................................................................hps.ts.hh..thR.....KtuhahlLAu...................ccatpssphppAhpshppAhtlYs..........................................ttsWsthp-a............ltt	.....................................................................................................................tshpth.ph.tp.p.....................P.aht.s...ph..lc.halllHDt.....ttss.pp..........spthhcph+p.....phuh.pshlLpl............................t...sp.....pss.p.............................s.h.ph...pt......t...................................................................................................................................................................................................t.hssh.ls.pDh.sslc.shlp-hshptllPa.........................hE+plphhs-p.lss..........++ul...ssphh.hs.....+..+a...as...................ssptssts.ss.t......................................................................................................................................................................t.hYt.posE.hthR+luDhsFhlpca.clAhstYchh+p..Da..pDpAhhah.....Au..sh.EMsu....lohhhtsts.................................tp...t.hh-p........Ah.sYhs.........................................................................t......huhR.ssllhsEl..............l........................+spst..h..puss...hh+ht.......pp........tlt....................................................................suLlhEpsuhsa...............................................................................................................................................................................................hp..h...h...hR.....KhuhahlLAu...................ppatptsphppuhpshppAhtlap...............................................................................................................................................................	0	83	136	219
+12575	PF12740	Chlorophyllase2		Chlorophyllase enzyme	Coggill P	pcc	manual	Family	This family consists of several chlorophyllase and chlorophyllase-2 (EC:3.1.1.14) enzymes. Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyses the hydrolysis of an ester bond to yield chlorophyllide and phytol [1]. The family includes both plant and Amphioxus members.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.87	0.70	-5.50	21	87	2012-10-03 11:45:05	2010-02-01 17:54:43	2	7	51	0	43	2038	336	210.10	26	60.91	CHANGED	sPPKsLllshPsptGs..YPVllFhHGah.lhNsh.YoplhpHluSHGaIVlAPQ.................hYs........lhs...ssspcElpssAplhsWLsp...GLpshLP.....ss...VcPshp+luluGHSRGGKsAFAlALGh.ss...................plpaSAllGlDPVs.....Ghspstps.P.lLTa.pPpSFchs.hPshVIGTGLGs.t+.s.hhPsCAPsGVsHp-FasEC..psPshHFVApDYGHhDMLDDs.......shhu.thshshCKsGt...s+pPMRRFlGGlhVAFLpshlpGc.tscLpt	.......................................................................................t..............p.....p.....t..tt....a....PVllFh.p......G......hh......h........s....s.....h.....Y.....s.....p....l.....h.....p..H.......l..A...S.....a.G.a.l.V.l..usp..............................................................ht........................hts.........s.s...p.....p...l..p......h..h...t....l......h....s..W.....h.sp...........sL...p...s.......h.s...........................t....s...p..s......D........h......s..+.....l..ul..u.GHSpGGc...s.u.h.s.hs.htt....................................................................hp..s.l..h.hl-....P...s.s....................t............h....................h.sh....p.......h..t...s......h.Ps.hl..h..GoG..hu..............C....sstuhsat....pFapth..tssthth........h..tphG.HhDh..lcss.........................hC.ts..........hh....s..huh..............s....................................................................................................................................................................	0	17	35	39
+12576	PF12741	SusD-like		Susd and RagB outer membrane lipoprotein 	Coggill P	pcc	JCSG_target-390164	Family	This is a family of SusD-like proteins, one member of which, BT1043 (Swiss:Q8A8X4), is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologues in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	20.50	20.50	21.00	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	529	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.94	0.70	-5.92	5	684	2012-10-11 20:01:02	2010-02-01 18:05:50	2	5	145	12	136	1575	477	436.30	24	89.00	CHANGED	MKhpNIKshhph...LSlusLlLGusuCTuNF-.DINoNPhtlTc-DhchDshslGuhhssLpuuVl....s.pssocsNsYQlppsLsuDsauGYau.psTsFsuosNhoNYshsssWss..hlachlaosVYsshpclcphS..-socsPshYALApIlKVAAMHRsTDhYGPIPYSKl....Gp.sohsIPYDSQE-VYsuFFKELDEulplLs-plssupsu.....hpuhDhV.YpG.....cVpKWlKFANSL+LRLAIRIVpVcPuLAKEhAEKAVs.ppuGVI-sNsDNAch...sssshoNPLthIussWs......DTRMuADlhSYMsGYQDPRtAsYF-c.........s.thsssYKGlRsGIsl.ppK-sapsYS.......+PslosocPlhWMNAAEVsFLRAEG.ALRGW.NMGGTAp-LYEpGI+LSF-QaGl.sSuAsoYlADsTssPAsYTDPssscssAsAlSuITV+W-EGAopEEK.LERIITQKWIAhFPpGQEAWSEYRRTGYPKLlPVlsN..NSGGsIsos...sGlRRLPYPpoEYsuNupsVpcAV.uhLGGPDNGAT+VWWDKK	................................................................................................................................................hh.........................h......h...h................uC...t.....t..t...ap..phNp...s.........t.......s.............................t............t...........h.t..h....t...hh...................................h..Q.....h.......s.h...s.s....h...u...s..a..ht...........t.............s..t..p......s....s..a......s..............p....s.....a..t........h.a..p......t.......h......h..t....t...h..h...s.....t..h...p..l.......t.......................t......t....t......s.............h.....h......u...h.s..p......lh...cs...hhh...tp...h.sDhaG..s.lP..Y..s.ph............ut.....t..........t.....h....t....s....................Y.....D..s.pcp.....l..Y....p........t....hhp-.....L.sp...A.hsh...lp...t.......p.t..s.....t...............h.t...ph..D..h.l...a.t...G..............shppWh+aANSL+LRhAh....R...ls..........s....s.....s......t.....h....A.....p......p...........sp.....p..A...l.....p.............h......G...l.....h....p..s.s.s.........-........s...s.hh........................s....h....p.....N.....s.....h..........h....h..............t....as...............................-.....t....h....s....u...s...h.........s......h....h........t.....u......h....p............D........P.R...h.......h.h.....at.............................................................t.t....t....a.........G......h..................G......................................t....t.......t...........h...t.......t......h.S.............................t.........h....t......t.....s.....s...........h....h....h....h.psu..EshFLpAEu...ul..p....sa...sh.s...s...s.......A...p..s...h.Y...cp...Gl.........p........h.........S.......h.......p......p................h...........s...........h.........t..t....h.t.t...Y.h...t.............p.....t.....................t............................t.a........s..s.......................t.................................................s..t...h....s...............t......a......pt........s....s......s...............p...p..p..L-pIlT.QK..al..A......a.P.....u....E.u...Ws-h...R...R...T...G...Y.......P......p....h........h........s....s...h...s............s....s....s........l.sst.......................p......R.h.as.......s..t..p.t..s....t..t.h.t..t.uh....t..h.....L........s.........G...............D......p.h..sTclWWsh..........................................................................................................................	0	64	120	136
+12577	PF12742	Gryzun-like		Gryzun, putative Golgi trafficking	Coggill P	pcc	manual	Domain	Members of this family are involved in Golgi trafficking.	21.30	21.30	21.80	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.59	0.72	-4.16	7	7	2012-10-04 00:47:01	2010-02-02 09:42:44	2	2	5	0	6	116	1	58.60	26	9.76	CHANGED	th.pcs-lh....htV-...ScsFhhpG.pplphplhsGpcpch.asFhPLhsGh.hLPplsI	.............t....tscLl....lpV-p..sctFhlsGhs.phphpl..supphpl.apFlsLpsGhhhLPpIpl..........	1	4	5	5
+12578	PF12743	ESR1_C		Oestrogen-type nuclear receptor final C-terminal 	Coggill P	pcc	Willis S	Domain	This is the very C-terminal region of a subfamily of nuclear receptors that includes oestrogen receptors and other subfamily 3 group A members. The actual function of this region is not known, but the domain is absent from all the other types of nuclear receptors. Oestrogen receptors modulate AP-1-dependent transcription [1] through two distinct mechanisms: via protein-protein interactions on DNA; and via non-genomic actions. The mechanism used depends on the cellular localisation of the receptor. In addition to the more extensively studied cross-talk on DNA, additional non-genomic actions might be very important in target tissues in which membrane-associated ERs are found. These non-genomic actions probably contribute to the overall physiological responses mediated by ligand-bound ERs [2] and might possibly be mediated via this C-terminal domain.	22.00	22.00	22.60	23.70	19.20	21.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.09	0.72	-4.42	17	117	2010-02-02 09:45:35	2010-02-02 09:45:35	2	7	69	0	25	113	0	42.60	53	8.76	CHANGED	Pss+sus.hEEpspSQL.TouSTSuHSLQsYYls.pEtEsh.sTl	...PsuRuuushEEssQSpLuTsuSTSSHSLQsYYIs.tEsEuhPsTl.....	0	1	1	7
+12579	PF12744	ATG19_autophagy		Autophagy protein Atg19, Atg8-binding	Wood V, Coggill P	pcc	Wood V	Domain	Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. In contrast to autophagy, however, the Cvt pathway is a highly selective process that involves the sequestration of at least two specific cargos that are resident vacuolar hydrolases, aminopeptidase I (Ape1) and alpha-mannosidase (Ams1). These proteins are sequestered within a double-membrane vesicle, termed a Cvt vesicle. The Cvt vesicle is fairly consistent in size, and is much smaller than the autophagosome, being 140-160 nm in diameter. The prApe1 is sequestered within either Cvt vesicles or autophagosomes, depending on the nutrient conditions, and delivered to the vacuole. Autophagy and the Cvt pathway are topologically and mechanistically similar and share most of the same machinery. The Ape1 complex is ultimately enwrapped within either Cvt vesicles or autophagosomes at the perivacuolar PAS. The receptor protein Atg19 binds to the Ape1 complex through the prApe1 propeptide to form the Cvt complex in the cytosol. In the absence of Atg19, prApe1 can form an Ape1 complex, but does not localise at the PAS. Atg19 is a peripheral membrane protein with differing binding sites for both Ape1 and Ams1. The Atg8-binding region in the yeast proteins is this very C-terminal residues [3].	25.00	25.00	34.90	32.90	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.57	0.70	-5.11	10	35	2010-02-02 09:48:03	2010-02-02 09:48:03	2	2	24	6	16	35	0	228.10	40	50.46	CHANGED	tsIplPED+PELlsFFo.....clcTscQLp-VaptY+sYE+LhQchDupch+h..h....T.huoscuhKphsIphE........ssPN-cLLplphup+DNSLaFpLaNpTNplluGNCpLcF.....psooQIp..h.IcMGPHEIGIKpaKEhha....FPpsho.hussTh-lVNQDGElIhlGKhusSs.IsL+sP.uphSstShQsu.....Q-Ps.sFcsDoLsp.D-SSIlSTshshphD.....Gss.p+shTWEEl	......................................................s.sIplPED+sELlsFFo.....clcTspQLp-VaptY+sYE+...L.QchDuc.............T..huuscuhKptpIp.E.........sPN-tsLplshsp+DNSLaFpLaNpTNpllsGNCpLcFp......spsooQI......IcMGPHEIGIKphKEhpa..............FP.thsh.us.Tlcl.N...Q.G-VIalGKh..u...s..S.s..IsL.+....sP.uphS....sp.ShQsu...........Q-..Ph.sFphD.sLsp...D-S.SIlSTohohphD.......Gss.p+sh.TWEEl............	0	2	7	12
+12580	PF12745	HGTP_anticodon2		Anticodon binding domain of tRNAs	Wood V, Coggill P	pcc	Pfam-B_20896 (release 24.0)	Domain	This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations.	21.00	21.00	21.10	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.66	0.70	-5.25	30	206	2012-10-02 17:25:11	2010-02-02 10:11:00	2	13	179	0	150	351	11	226.00	26	14.78	CHANGED	W+spRCDVLVuSFssslLcosGlcllppLWupsISADl.hcss.ShE-llsphppDGhsWIVllKQ.................................t.csp.+sLKVKslsppc..DsDlc.h-EllsaLcsEl.....pt.+p..pcptssspsp.hppsspptsshss..........................pppslhl.sstsRuK.KsN++spW.Ehc.tAptuoppllcshh.....suPIhAlDs.RDElL-hIphToLu.pt-pW.R+Vhts.ssss.RpYsspIastLt..+pts+up+...........hAhlYshRTGcsslhDLp	......................................p+CDVLV.sShss...ss.L.o.pulpllppLWstsIoA-lhh-..s...s.......S....E-lhptsp..ccs.hsallll+p....................................sut....lK.VKslppcc.....-h-..l..p...ts..-Llsalppcl...........cp.+......pctt..t...t..t.....t..s...s..s...........................t.....l.l.sstp.h..ut.p.p.+R..h....p....h..t.tplhpp.......p.h...lhsl-h.p-plh.phl..p.....p....hs.p.pta....pplht.......hs.h.+.p.ahttlhp.l.......p.tt...c....t.............hhlas.h+ss...............................................................................................................................................	1	41	80	119
+12581	PF12746	GNAT_acetyltran		GNAT acetyltransferase	Coggill P	pcc	JCSG_pdb_2jlm	Family	Many of the members are annotated s being Zwittermicin A resistance proteins, whereas others are listed as being GNAT acetyltransferases.  The family has similarities to the GNAT acetyltransferase family.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.64	0.70	-5.57	2	486	2012-10-02 22:59:21	2010-02-02 13:52:51	2	2	325	2	48	433	12	231.20	31	95.29	CHANGED	Mh.ph.....cphsphFtDaspsllhohLpGhMGshaVsD.p.PpsA.hhhG...hFsFhAGps+....c-LL+.h.s+.hllV.ps.pWpchlEshYtctIcpFhRYthK+ssE.FDhu+LQpLlssLPcua-h+RIDcNlhpsshlcchS+Dhsupa.sVEpalshGlGYsILaKGpVVsGASSYu.YssGIEIEVsTccsYRthGLAphsuAtLILsCL-+GlYPsWDAtshTShKLAEKLGY.hDKsYpsY...........p.p	.........................................................................................................................................................................................hlh....hl...p.u...h.Gp..lah....ss.......p..s..ssh..h.....h.G.......aha..h..uG....p.....s...........p...............p....c.h...h.......p....t.........h.......t.....p.......t.....h....h.............l.............l.....s....ps.......p...p.W..pphl......c.p..h.....h.p.p......t.l...pp...............hs..Rht...a...p.p..psp........F.p...p.t...hpp...h....s.p.l..p.sYp..........lp.ID.p.ch.hpp.........t.....p..c.....a....o...p....-...h........hs.p.a..p.S.h.c.s.F.....l.p..........t.G.hG....as...I.l..h..s..s..p..l.l...u.s.ssS.hh.s..a.p.st..h..EI-.ls..T.c.sa.pscGLA.ptluuth...I....h....-CL....p.....p...s...lh...P...t...W...D..s..c..N..h..s..St+lAcpLGaphstsYpsa..............h....................	2	21	36	42
+12582	PF12747	DdrB		DdrB-like protein	Bateman A	agb	Bateman A	Family	This family includes the Deinococcus DdrB protein which is a ssDNA binding protein. This family also includes some possibly distantly related cyanobacterial proteins. However, these are not strongly supported. The structure of DdrB is known.	25.00	25.00	33.70	33.50	21.40	20.00	hmmbuild  --amino -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.64	0.71	-4.41	6	17	2010-02-03 15:48:23	2010-02-03 15:48:23	2	1	11	5	15	19	0	133.50	37	80.75	CHANGED	M............pl.ahss.hsKsThsl..tshLhDVpcthsR.s..................hosuE..sssYQaPL-p.hsFDWshIGAR.chossEGtplV.aRG+uacRRc.pssD....KhsAAIhFSpusKs.........sDG-hc.YlpLhhFRstp	.....................................pl...ss.hscsohpl...s.Lh-Vpphhup.s..................hoss-.sssGaphPLspttsFDWshIGAR.hhossEGtphV.a+G+sa+RRcLpssD....cLPAAlKaSRGAKs.-.....chsDGchc..YVoLhhFRst........	0	1	9	15
+12584	PF12749	Metallothio_Euk		Eukaryotic metallothionein	Wood V, Coggill P	pcc	Wood V	Family	This is a family of eukaryotic metallothioneins.	21.80	21.80	22.50	21.80	21.20	21.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.49	0.72	-11.35	0.72	-3.94	4	26	2012-10-05 18:33:37	2010-02-03 17:50:25	2	2	15	0	5	61	0	67.00	50	92.47	CHANGED	Mtt.sp...TpsChCsss.....CpCG..csCsCp.....stCGCssCKs......................uC+CSusssssCKCT...SCpCpp....p	......Mss.spsh.TssChCs.ssps..t.hC+CG..cACpCt.....ssCuCs.sCKs....uC+Css.s.ps.ssC..cCoustsC.Ctp.t.......	0	4	4	4
+12585	PF12750	Maff2		Maff2 family	Bateman A	agb	Jackhmmer:Q187G1_CLOD6	Family	This family of short membrane proteins are related to the protein Maff2. Maff2 lies just outside the direct repeats of a tetracycline resistance transposable element. This protein may contain transmembrane helices.	27.00	27.00	29.30	29.30	26.70	26.20	hmmbuild  --amino -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.41	0.72	-4.45	7	359	2010-02-04 13:16:13	2010-02-04 13:16:13	2	1	171	0	29	229	33	58.10	69	94.26	CHANGED	MtFFsSAlssLpTLVlALGAGLuVWGVINLLEGYGsDNPGAKSQGlKQLMAGGGlhLIGhTLlPLLSuLF	......MtFFspAVsVLpTLVhAlGAGLGlWGVINLhEGYGNDNPGAKSQGhKQLMAGuGlhllGh.LlP.Lushh.....	0	23	29	29
+12586	PF12751	Vac7		Vacuolar segregation subunit 7	Wood V, Coggill P	pcc	Pfam-B_10847 (release 24.0)	Family	Vac7 is localised at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance [1]. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway [2]. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.	25.00	25.00	32.90	26.00	22.70	22.40	hmmbuild  --amino -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.54	0.70	-5.61	7	172	2010-02-04 17:05:01	2010-02-04 17:05:01	2	3	110	0	128	174	0	228.40	26	39.02	CHANGED	IVETETVSSIPQVuLGsGsGERGsuuRsD.uGolRhKsSsETIRP+KEKKKo.RKPsA.LssGssSSKADIFEAKVASAVDEADsSDS-ETFVYESNPPDsaPsRp.RYHSRTPSATSMASQsDQhuGRoRhuhRDs.HulTGKRSMKFTNs.sY..uol-GDh.spcsu+upuRss.Gp.sHTsRHHHIGR.HGR.us...aPSLFDs-SPFspSQ.p.+SsRHalusuhRQupp....R.sssNYRoh.susKKsG-.YsYDFD.uEGADDERTPLVGSs.RssRSRpG.RRPNSASLRQMEYMppRpRShFuRYGhChllhlLlllllGGAToFllulh+PLlDVpVhtIQNVLASEQEIMlDLpVpAlNPNLhsloIsDMDVNIFAKSRYVGoDph.WR	......................................................................................................................................................................................................................................................................oKsDhF.tA+lAsA..Vs-sp.SDStE.....T....FlY-sss..p..............................................................................................................................................................................................................................................................................................................................................................................................................................................................h........hh..h.h.hshhhu..p.L.thtl..hpp.lsSpt.lhhsh.htAhNsshhslsltthphplFA+S.a..............................................................................................................................................................	0	24	64	111
+12587	PF12752	SUZ		SUZ domain	Aravind L	agb	Aravind L	Domain	The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.	27.00	27.00	27.30	27.30	26.80	26.80	hmmbuild  --amino -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-3.44	57	527	2010-02-10 14:08:56	2010-02-10 14:08:56	2	8	208	0	305	471	0	58.00	34	9.30	CHANGED	ptsphpIh+R....................Pstsssps...............tssspsttsptscolEEREtcYpcARpRIFusss	.................................phhIL+R.................................sttsssss.........................tp..pss.pss..ptsKSlEEREpEYpcARcRIFupt.s.............	0	78	133	211
+12588	PF12753	Nro1		Nuclear pore complex subunit Nro1	Wood V, Coggill P	pcc	Pfam-B_4826 (release 24.0)	Family	In fission yeast, this protein is a positive regulator of the stability of Sre1N, the sterol regulatory element-binding protein which is an ER membrane-bound transcription factor that controls adaptation to low oxygen-growth [1]. In addition, the fission yeast Nro1 is a direct inhibitor of a protein that inhibits SreN1 degradation, Ofd1 (an oxoglutamate deoxygenase). The outcome of this reactivity is that Ofd1 acts as an oxygen sensor that regulates the binding of Nro1 to Ofd1 to control the stability of Sre1N [2]. Solution of the structure of Nro1 reveals it to be made up of a number of TPR coils [3]. TPR proteins are composed of three to 16 tandem peptide repeat motifs of 34 amino acids with degenerate sequence. The helical pairs adopt a helix-turn-helix anti-parallel arrangement with interacting helices. In general, TPR motifs are stacked together so that helix A from TPRn is packed between helix B from TPRn and helix A from TPRn+1. In Nro1, the 12 alpha helices forming the six TPR motifs are organised as follows from N terminus to C terminus - TPR1A, TPR1B, TPR2A, TPR2B, TPR3A, TPR3B, TPR4A, TPR4B, TPR5A, TPR5B, TPR6A, and TPR6B with the C-terminal helix (hC) running above the sixth TPR motif with an angle of approx 45 degrees with TPR6A and TPR6B. The corresponding TPRs structural motifs are longer (50 residues) than are canonical ones (34 amino acids) and are organised into two subdomains - Nro1-N (residues 55-225) and Nro1-C (residues 226-393). The Nro1/Etti protein plays a role in nuclear import suggesting that it is residues 4-19 that are interacting with Ofd1 [3]. 	20.80	20.80	21.00	20.80	20.50	20.20	hmmbuild  --amino -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.31	0.70	-5.52	18	53	2012-10-11 20:01:03	2010-02-10 15:57:53	2	2	46	5	37	55	0	357.50	36	97.70	CHANGED	M.A..KRsLGLGKts+tKKpKh.............psspsscpsss....ssplpVELsEthDs-DEluQL+uLWcsYhcS-+DsEl.....llNGIlHECDRLLRpp...............pp-cth........pLsc.FHuIYALALuELshF+st-pp.............plppaF.DsALERs-lG.hpphscS.hLhlspuKIllp+IPLpYISpLss-Spsp....pl.p.L-pAhpsaphsppphp............sh-lLphlDDLLDIl-NFG+c.pp.pEs.DsD-......t-t.-..plcLscpHPLYtlpps.t.N.pWhR-phlthLsslpc...........................spLhRpls++LGQsYLpcAE.PosVFsoLpYD-..t.ps.cp.hph..tcpAQchAppLhccAlcYLccAcs........---P-TWVslAEAhIsLGNLa-s-ScEQEchYpcAEcILpKANpATpGKYcDlL-NLL	........................................................MA..KRsLGLGKts+tKKpKhpp...........ppppsstpsss......pspholEL..s--sDh-DEluQL.......cGLappYhpS-+DsEh.................lLNGIlHECDRLLR.p...............-ppp...........pLss.hFauIYAlALuELshF+st-pc.............plppaF.-sAlERl-hG.Lpphscs..LhlshuKIlhp+IsLpa.ISpLplcScsp.....phcl..p.L-puhctaphh.cpcsp..........................sh-lLp...hlsDLLDIl-NFG+c.pp.p-s..Dp-s......................---.c...plcLp.pHP..la.lpps.phs.pWhRpph.phlcshpp...............................plhtplspplGp.YLpcAE.PsplahsLpY-c..t.tt.pp......pshptppuQchA.chhppAlcYLcpAp.........c--P-TWVplAEAhIsLGNLh-.-StEQEchYppAEcILt+ANpuopGKap-lL-Nl..............................	0	12	24	36
+12589	PF12754	Blt1		Cell-cycle control medial ring component	Wood V, Coggill P	pcc	Wood V	Family	During size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1, Blt1 has been shown to co-localise with Cdr2 in the medial interphase nodes, as well as with Mid1 which was previously shown to localise to similar interphase structures. Physical interactions between Blt1-Mid1, Blt1-Cdr2 and Cdr2-Mid1 were detected, indicating that medial cortical nodes are formed by the ordered, Cdr2-dependent assembly of multiple interacting proteins during interphase. Q5KIH8.1/10-346; Q5KIH8.1/10-90;	27.00	27.00	37.10	29.50	21.10	26.60	hmmbuild  --amino -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.04	0.70	-4.83	29	75	2012-10-03 10:59:06	2010-02-10 16:13:33	2	2	70	2	62	73	0	210.10	38	91.22	CHANGED	Fs.....................................KSFLuuLDS..........................RPlKLs....................................................uDaVhDPcshshpsP.................YTLPRLps.PHP......................................MPKKh...............................KpstsPGSSKSIolp....................LKSARNPsLcloLsNs.sluo.............................TSVp-LK-sVppRl.ssp...........ssplPlDKIK.....ILaK+KPV...sucTlu-lLus..-sthluGGcElEh.GVMIhGGA.pls.s...........................................tttttttp.pp.hss.....ss.u......so...................uppVltTEtFW-D...............................................................................................................................................LpuFlpp+lK.DttpApplpsl..F+tAWpus	.....................Fs.KoFLusLDS..........................+PlKLs....................................................uDaV.DPcsasspsP.................ahLPRhss..+........................................................MsKth...............................ppshsPGo..s...+S...IoVp....................LKSs.RNP.sL.clsLssh.slso.............................TSl.-lKpsVpp.................psplPlDKlK.....lLap+KPV...suKolt-lL........us.......su.spplEF.uVMlhGGAssh..ss....................................................t...t.........................................s.tllts-tFWtD...............................................................................................................................................Lpsah..+l+.s...utph..h..F+tuW.t.t...................................................	0	10	28	48
+12590	PF12755	Vac14_Fab1_bd		Vacuolar 14 Fab1-binding region	Wood V, Coggill P	pcc	manual	Domain	Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.18	0.72	-3.60	35	386	2012-10-11 20:01:03	2010-02-10 16:22:32	2	28	266	0	281	523	5	95.30	42	10.54	CHANGED	NtRpGGLIGLAAsuIALGpc......sspalcpIl.PVLsCFsDpDsRVRYYACE......SLYNIuKVu+uplLh..aFN-lFDsLs+.....LsADsD.sV+sGAcLLDRLlKD	.....................tRpGGLlGLAAsuluLupc..........sstYLccll.PVL.sCFsDpDsRV.RYYACE......uLYNI.s.KV.u...+.G..c....l.Ls....aFNclF.DuLsK.....................Ls.uDs-.s..V+suA.EL.LDRLlKD...................................	0	99	154	226
+12591	PF12756	zf-C2H2_2		C2H2 type zinc-finger (2 copies)	Wood V, Coggill P	pcc	Pfam-B_88 (release 24.0)	Family	This family contains two copies of a C2H2-like zinc finger domain.	21.70	10.00	21.70	10.00	21.60	9.90	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.23	0.72	-11.09	0.72	-3.90	112	2196	2012-10-03 11:22:52	2010-02-10 17:43:06	2	245	346	2	1419	5276	41	77.00	18	19.96	CHANGED	p..CLFCspp.....ss.hc.......pslpHM......hppHuhalP...-pcaLs..DhpGLlpYLtcKlsh......tphClhCppp.tp...ohpul+pHM..psK.sHs+lsh..csptp....h-hscFYDa.psshs	...........................................................................t...................................................................................................................................................................h.t.........................................hpChh......Cspp...ap....................ohp..s..lptHM....p.p..p...t...Hh.t.........................................t.....................................................................	2	388	637	1011
+12592	PF12757	DUF3812		Protein of unknown function (DUF3812)	Wood V, Coggill P	pcc	Pfam-B_8029 (release 24.0)	Family	This is a family of fungal proteins whose function is not known.	25.00	25.00	31.90	31.90	20.00	19.60	hmmbuild  --amino -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.35	0.71	-4.15	39	146	2010-02-10 17:51:15	2010-02-10 17:51:15	2	1	115	0	106	150	0	123.70	26	14.39	CHANGED	spssLhpsApcNscsplpsh-pcshtp..............shphppchpcpAlttAppp.....tptppppssplslG......GGhals.s-l-slApphlpPsLc-Isc+A.......-tpRsp-h-t+hcpcctccptppt+pcEcct+p	..................................pttlhttApcssptpLpsl-pcshtp....................th.p-apppAhthAppp......................tptpppspsplslG......GGhahs.p-lsslApp+lpPlLs-Is-+A.......cppRtc.......-tph+hcpcctccptppt+pc-cphc...................	1	17	53	90
+12593	PF12758	DUF3813		Protein of unknown function (DUF3813)	Mistry J	jm14	PfamB_1273 (release 24.0)	Family	This is an uncharacterised family of Bacillus proteins.	25.00	25.00	45.30	26.00	24.10	24.70	hmmbuild  --amino -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-9.17	0.72	-3.83	4	128	2010-02-11 10:51:27	2010-02-11 10:51:27	2	1	128	0	17	59	0	62.90	68	92.96	CHANGED	MtNpLaQpA+shVpphlSpuuus...EQQpsl.+AKNAlpSAYANSosAE+pQL+phQ-QLppls	...MGNLLFQQARDAVtsAVSCS.S.Gs.......EQQ-L....VYRAKNALpSAYANSSTAEKVQLREMQEQLQsIp...	0	1	9	11
+12594	PF12759	HTH_Tnp_IS1	InsA_C;	InsA C-terminal domain	Bateman A	agb	Bateman A	Domain	This short domain is found at the C-terminus of the InsA protein. This domain contains a helix-turn-helix domain.	21.70	21.70	21.70	22.00	21.60	21.60	hmmbuild  --amino -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.20	0.72	-4.53	4	1328	2012-10-04 14:01:12	2010-02-11 16:39:48	2	7	456	0	75	676	9	42.40	62	42.85	CHANGED	YoYcAppPGhKEpIl-MAhNGAGsRhTARsL+IGINTVlRTLKNSR	..........aTYsAsQP...Gs+p.KIIDMAM.NGlG........sRsTARl.ht.VGlNTll.RpLKNSt............	1	16	31	61
+12595	PF12760	Zn_Tnp_IS1595	Zn_ribbon_3;	Transposase zinc-ribbon domain	Bateman A	agb	Pfam-B_3 (Release 24.0)	Domain	This zinc binding domain is found in a range of transposase proteins such as ISSPO8, ISSOD11, ISRSSP2 etc. It is likely a zinc-binding beta ribbon domain that could bind the DNA.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  --amino -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.85	0.72	-4.15	73	764	2012-10-03 10:42:43	2010-02-11 17:07:24	2	7	279	0	235	786	170	47.70	34	15.88	CHANGED	ssEcpstphLpphRWssG.....hs.CP+CGsp...chaplps.........tthapCpp..Cp+p	...............s-ppChphLpphRWPpG.......hs.C.P+Cusp...tthphpp...............pph..a.pCps......Ct+p..............	0	51	128	153
+12596	PF12761	End3	E3;	Actin cytoskeleton-regulatory complex protein END3	Wood V, Coggill P	pcc	Pfam-B_51079 (release 24.0)	Family	Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release [1]. End3p is part of the coat module protein complex Pan1, along with Pan1p, Sla1p, and Sla2p [2]. The proteins in this complex are regulated by phosphorylation events. End3p also regulates the cortical actin cytoskeleton [3,4]. The subunits of the Pan1 complex are homologous to mammalian intersectin.	25.00	25.00	25.80	25.00	23.80	23.30	hmmbuild  --amino -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.44	0.71	-4.66	21	129	2010-02-11 19:37:22	2010-02-11 19:37:22	2	5	114	0	90	124	0	172.20	38	48.58	CHANGED	sKDtsLsFLHILNQRcc.GhRIPRsVPASLRAoFpKpp.sYsLs......pspsph.tssssssTss.pKtpFu-sYLs+l...Ghusp..........shp...ppGTDFSu.spsoDWEEVRL+RELA-LEshLscspptscsp.........spsspsp.uLlKcEhEQLLcYKccpLpphp...spussutsLpsl+cDlchlcpQVssLcpaLps+pppLpcLcp	............................sKDssLsFLHILNpRc-.GhRIPRslPASLRuoFppsplsYplcs.........tstpph.tsptsspTsou..pKtpFu-tYLs+lGhus.............pstGTDFSs...psp-WEcVRL++pLt-L-pclptspttsppp..........ttpstsp.sLlKc...Eh.QLLcYKccpLpchpp..ucsptutsLcplp-DlpslppQV-sLcsaL...tp+pp.LppLp.t..................................	0	16	44	76
+12597	PF12762	DDE_Tnp_IS1595	Transposase_38;	ISXO2-like transposase domain	Bateman A	agb	Pfam-B_3 (Release 24.0)	Domain	This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.74	0.71	-4.38	78	1888	2012-10-03 01:22:09	2010-02-12 10:55:34	2	15	595	0	571	1721	293	125.10	25	51.91	CHANGED	hLsG..........VE.........lD-sYl..GGcp....p......sp......cG+.......s........t..ssKssVlshl-ps...................t.sh+shstll.ts.hstpsltshl....pctlptsuplhTDphssYsslstt..asHpplsastp......hs.......tt.....sshshlcshhuplKRtlhGsaHtlu.scaLppYlsEhsaRaN	.........................................................................tG......lp........hD-s.hh.....utpp............................tp.......................tG+.......s..............................................ttKh..lhs..hlcps.......................................pshh.hl......ss..hpptsl...h..l...............tpp.lp.s....s..uh......l.h..o.D..s..htu..Y.p.....t.L........p............t...t........a..t.......H.......h........t...l.spu...tp.............s.......................pt........phphlps.hhs.p.hKphl..t....t.aps.ht.tchh........aLtch.a+.................................	0	221	343	458
+12598	PF12763	EF-hand_4	efhand_3;	Cytoskeletal-regulatory complex EF hand	Wood V, Coggill P	pcc	Pfam-B_51079 (release 24.0)	Family	This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.43	0.72	-4.29	13	2526	2012-10-02 16:17:27	2010-02-15 09:18:54	2	126	302	12	1472	3070	25	94.90	32	17.53	CHANGED	MP...+LE-aEIKKYW-IFpGLpPtsNKLoGDpVuPVLKNS+LssDQLu+IW-LuDIDsDGpLDFEEFCIsMRLIFDlVNGshssVPscLPsWLVPuSKAHLIQANc	...................................hht.............p.ap.p.lF..p...s.h....s..s..h..s.....G..h..l.oG.s.p.A....+....s.h...h..h....p.....S....p....L..P..p..s.h...L...u..c.........IW....s.............L....u..Dhcp-G..tLstpEFs..l...AM.+.Ll...........h..h..p..t................................lPt.L.Ps..t.hh..............ttt...............................	0	408	686	1107
+12599	PF12764	Gly-rich_Ago1		Glycine-rich region of argonaut	Coggill P	pcc	Pfam-B_7248 (release 24.0)	Domain	This domain is often found at the very N-terminal of argonaut-like proteins.	25.00	25.00	34.20	33.60	24.10	21.10	hmmbuild  --amino -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.60	0.72	-3.39	12	50	2010-02-15 11:44:43	2010-02-15 11:44:43	2	2	30	0	16	50	0	101.70	50	14.75	CHANGED	GGs.EYpsp...GRGsPP.Q..GGpsth.GGGpuGu.......Pss.....s.R.ssPELHQAT...pssYQA.hss.PhP........SEsusSstP.spsssh..tQQFQQLolpQtu.oSQAIQs.Pu	................GGP.EYQuR.....GRGG..Ps.Q..........GGtsta..GGGRGGu.............PSu...ssP.Rp..oVP.ELHQAT...pss.YQA.VsopPos........SEsusophP..scssss..tQQFpQLulcpt.u.sSQAI.QPhPs......	0	1	8	13
+12600	PF12765	Cohesin_HEAT		HEAT repeat associated with sister chromatid cohesion	Wodd V, Coggill P	pcc	Pfam-B_443 (release 24.0)	Family	This HEAT repeat is found most frequently in sister chromatid cohesion proteins such as Nipped-B. HEAT repeats are found tandemly repeated in many proteins, and they appear to serve as flexible scaffolding on which other components can assemble.	21.00	8.90	21.00	8.90	20.90	8.80	hmmbuild  --amino -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.61	0.72	-3.95	52	424	2012-10-11 20:01:03	2010-02-15 11:48:56	2	36	262	0	276	589	36	37.80	32	2.43	CHANGED	+slstllptDsslLsps....plppslpp+htDsussVR-Asl-Ll	....................+sl..hlthDsplLst................ph.phlpp+h.tDsu.ssVR-AAlpLl....	1	90	146	220
+12601	PF12766	Pyridox_oxase_2		Pyridoxamine 5'-phosphate oxidase	Wood V, Coggill P	pcc	Pfam-B_2486 (release 24.0)	Family	Pyridoxamine 5'-phosphate oxidase catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP), the terminal step in the de novo biosynthesis of PLP in Escherichia coli and part of the salvage pathway of this coenzyme in both E. coli and mammalian cells. This region is the flavoprotein FMN-binding domain.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.53	0.72	-3.69	60	319	2012-10-02 11:35:36	2010-02-15 12:53:17	2	6	304	4	186	1478	2504	100.10	30	42.69	CHANGED	huPW+shlppulcp......p..ssphhQLATls.s.ssp.....P+sRTlVFRGFhtp..............................ssshLphsTDtRocKlpplt...............p..ssts..EhsaaascotcQaRlpGpshlls	..................................h...Wt..htpulpp......t..s.phhpLATls....sup..................P.csRTlVaRuahtp...................................................................................................................sshLphpTDtRSpKltclt.......................p.sshsEhs.a..a...h..........s...........c...........stp...QaRlpGpstll.s........................................	0	55	111	157
+12602	PF12767	SAGA-Tad1		Transcriptional regulator of RNA polII, SAGA, subunit	Wood V, Coggill P	pcc	Pfam-B_319 (release 24.0)	Family	The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II [1,2]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA [3]. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.	27.80	27.80	28.10	27.80	27.70	27.70	hmmbuild  --amino -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.61	0.70	-4.71	65	356	2010-02-15 13:09:22	2010-02-15 13:09:22	2	11	232	0	254	344	0	212.60	22	55.99	CHANGED	hs.....tstRl-ltpl+pplhptlG.cphpcYhptLstFlh..............s+lo+pEh.sp.sptll.................spcp.....l+LHNpLlhuILsNu....htps....ss...ss...............................tptp.hstsssh..ssptspp.pphccphht.s.csptchpth...............................................t.t.t.....ssh.....tth.chs.hpstpphpph......................ppp.............................h.tt...shsscohpLPDspsLptRh.hhshcpGL........sulstssspllshuL-saLKsllpuslshsp	..........................................................st.......t.-lt.hhppltptlG....cphppYhttlphalh.............................t+ls+pEasp.stthL.......................................stcp...........l+LHNphlhuIlsss....tp........Ps...ts.............................................ttt.s....s....s..h..tst.ts.p....hptphh........ptph.ht..............................................................h.............t....ph.....hptspp..t.....................................................................................................................................................................t....h.s...cs.htLP-..ttplptRh..hs..hcpGL..........ssss.pssphlshul-salKpllpsshshht.................................................	0	71	137	208
+12603	PF12768	Rax2		Cortical protein marker for cell polarity	Wood V, Coggill P	pcc	Pfam-B_2071 (release 24.0)	Family	Diploid yeast cells repeatedly polarize and bud from their poles, due probably to the presence of highly stable membrane markers, and Rax2 is one such marker. It is inherited immutably at the cell cortex for multiple generations, and has a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means of coupling a cell's history with the future development of a precise morphogenetic form [1]. Both Rax1 and Rax2 localise to the distal pole as well as to the division site and they interact both with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical markers for bipolar budding [2]. thus Rax2 is likely to control cell polarity during vegetative growth, and in fission yeast this is done by regulating the localisation of for3p [3].	25.60	24.90	25.60	25.20	25.50	24.60	hmmbuild  --amino -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.89	0.70	-5.19	34	157	2010-02-15 13:49:32	2010-02-15 13:49:32	2	7	131	0	124	169	15	251.50	25	23.26	CHANGED	lhVGGsFppAGuLsCsulChashssspWspPuss......lpGsVsslpah..ss.spLlluG.sLTlss.sssslsoYshpspsapshtu.sp..t.ls.uslsuhshhtsDtsphhlsGp..upGssalhta...DGopWpphss.lhts..sTsIpulpllsL..s.ps+pp...sshhsssplLlloGplsl.sca..GpsSuALasGo..shhPalloo..................p...ssspsGslsplFhp..............................ssssaps.p....h....cphupG...hVVLIuhuhALGsshLlslhGlIhshhpp+ppthh.sspt.th-csp.hpplPP	..............................................................lhVGGsF..p.p.A...G..u.Ls.CsulCha.shssspWsp.Gss.......lpG..s.V..ssltas...ss..spLlluG.shs.....lss....s..sst......lApashpsp.s..Wsshsu.s...ttls.Gs.l...suhshstpsss...p..hhhuGp......s....s....u...ss..alhta...cGs.pWpsh...st..hhts...to.lpslphhsl..p...psctt...tshhspsp.hLhlsGpl.l.ssa..G...ssuslasGs..shhPahlos..................p...ssspsGt.hstlF.p....................................pp..hpt...............phhshG...hVVLluhslALGhh.....hllslhGllhshh.+c.ppt...h..t....hhpc...hptlsP................................................	0	45	77	109
+12604	PF12769	DUF3814		Domain of unknown function (DUF3814)	Mistry J	jm14	Pfam-B_10 (release 24.0)	Family	This is a domain of unknown function.  It is often found in combination with Pfam:PF05222, Pfam:PF01262 and Pfam:PF02233 on alanine dehydrogenase and pyridine nucleotide transhydrogenase enzymes.	25.00	25.00	30.30	30.30	22.90	22.90	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.07	0.72	-3.82	159	2249	2010-02-16 09:34:05	2010-02-16 09:34:05	2	12	2099	0	638	1524	1931	86.90	57	21.39	CHANGED	lttlslFlLAshlGa.VlhpVsssLHTPLMSsTNAISGIllVGAllth..u.............................hsplLuhlAlhlAolNlsGGFhVTcRMLpMF++	......h..phslFsLAshVGYaVVWsVo.ALHTPL....MSV.TNAISGIIlVGALLtlGpu...........................tshsphLuhlAVllAoINIF..GGFhVTpRMLcMF+K.........	0	187	373	522
+12605	PF12770	CHAT		CHAT domain	Bateman A, Rawlings ND	agb	Pfam-B_4 (Release 24.0)	Domain	These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins [1].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  --amino -o /dev/null --hand HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.14	0.70	-5.28	82	1893	2012-10-03 02:24:44	2010-02-16 10:52:24	2	520	555	0	959	2220	184	278.30	18	28.37	CHANGED	ptsuppLaphLlt.P.lttt..l.........tshp...pLllssDu......sLptlPhtu..Lhssp.........................paLlEc...asls..hhsShp....Lpphp.tshpstps..........Lshussphs......t........................................................................................................................ssLPusttE.hpslsph.............hhts..............pshhsppu..Thpslppth...........pphpllHlATHu.Fp.........................................ss.tpShlhLt..................................................ssthLshp-ltp..l....sLst...........scLllLSACpTu..........hG.........ss-uhhG....lstshhhAGspusluSLW.VsD..puTttLMppFYppLtp.......shttucAL+pAQlthhpsphh..................................................pc.PaaW...........uuF..hhhGs	.................................................................................................................................................................................................t......h.p.h.h.......s..h.t....l........................................thp..........plhh.h.sps............Lt.lPhth......l.stp.......................................................thlhp.p.......h...lt.....hhss.h..p..........hh.th..t.......tt.t..................................................hhh.u..ssp.................................................................................................................................................................................................................sLs.t.st..tE...h...ptltph.....................................ht.t.........................phh.ht.p.p....s.....ot..p.plhpth.....................pphp..ll..HhAsHGths...............................................................................................tt.s...p.u..tlhlt..............................................................................................tsthLs...h.p.-lhp....h......plpt.................spL..llLSA.Cpou...........................................................hst..........tsc..t..h...h.u..............Lspuhl.t.u...G..s.ps.Vlu...o..h..W..t..VsD...........pss.tt.hh.......pt..FYp.p.Ltp..................shshs.p.....A...L...p..pA.phthhpt...........................................................................................s..W.......ush.h..............................................................................................................................................	1	381	710	898
+12606	PF12771	SusD-like_2		Starch-binding associating with outer membrane	Coggill P	pcc	JCSG structure (Target 390167)	Family	SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.59	0.70	-6.10	5	655	2012-10-11 20:01:03	2010-02-16 10:56:58	2	5	160	4	277	1675	449	427.60	19	89.34	CHANGED	MKKpILlIVLu.....alClSCuNLEEMNINPspPTpTHPpLLLTslphssF+..pGToGlYAQKhllQsDGEsuDQYYKWsRGSFGuYsTLR........NVpKMsEEAERI..NsPs...................YhALuKFFRuYYFYcLTLsFGDIPYSQALKGETEp.YoPsYDuQEDVFcuILpEL+EAD-ILushsolIuG.......DIIYNGNsspWRKLINSFRLKVLlTLSN+S..GElshsSEFcuItTNSPLM-S.sDNGQLVaLDQQsNRYPpFNuuu.WSGhYMDuTFIQRM+ER+DPRLFIYSTQTsKuKs-GKsIsDFSuYEGGDPAAPYG-uh.KsucGDlS.lNDRa+pDPlsEPhhLhGYAEpQhILAEAAVRGW.IuGsAcsaYEcGV+uSFcFYEsaucDYutYLu.NAVApYLpEPLVD..................FopASSTEEKIERIIMQKYLsoFaQhsW-GFYDaLRTGYP-FRRPoGosIP..........+RWhYPQSEYssNosNVSoAIo+QFGuGNDcIspssWWtK	......................................................................................................................................................................h........h.h...h....s......s....s...p...p...h....t..-....l...N....p..s....P..s.....t......s...p.......p.......s.....s.........s.....t.......h.......l.......h..s.......t.......h...........h........p.......h.......h..t...................s.......................t.............h....h...........h.....t...............h.............h......t...........................s..........t.......................t......p...h.......h......t.................t......t.........s....t.........h......s......h...........h....t....t..h.t.................................s.h.....p...h.....h...p....t....s.....p..p..h........t.t..........................................................................h...h...u...l...u...pl.h..p.......uah...hthhsDhaGD.l.P.Y...o..........-..........A.....h.....p.........u........t........t.........................h..p.....P.....paD..s.Q...c.s......l.Y.....t....s.....l.........hp.......p.Lc.p..A........s....h.....l........s.....s.....s......s.....s..............h.....s..u.....................Dh.l.a.....s.....G......s.........h....s..........p......W....h+huso..L+l.Rh.h....h......+...l.s.....phs.......s.t....h.s....h..t..t.h.........h...t..t.....l....h.......s.....s.....t...s...h........h...p.....s......s.-........s.......h...................h...........h..............s...t........t.....s.....s....................s........h........h........t...............t.........t.......................h...............s....s..........h.......h...h............s..........p..h...h..h......s..............h...h...........p........t............h............p..............D.P...R.l..................h........h.........h.........t..............................................................................t..........................................t......................t.......h.................t.......................................................................s.........................................................................................................................................................................................s...h..................h........h..hshuEhtFlhAEu..h..h..+..u..h......h...s....s......s.......A...pph..Y...........p...p....ul.p.u....u...h....p........h..........s........h...................s....s....t..................................h.....h.......s......................................t...................................................................................................................t...t....t..l..p..p.Ih.h.Q.+alu.ha.....p..s..h.-sa.phRR.........o.....G............h......P..........t........h.......................s..................s...............t......hs...............................hRh...Y..P....t..p....p..h..N........th.....t................................................................................................................................................................................................................................................................	0	119	251	277
+12607	PF12772	GHBP		Growth hormone receptor binding	Coggill P	pcc	Pfam-B_7 (release 24.0)	Family	Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme) [1,2]. Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone [3]. The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage [4].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.00	18	1202	2010-02-16 14:01:20	2010-02-16 14:01:20	2	6	789	0	38	1084	0	236.70	57	83.11	CHANGED	KGKL-ElNoILuup.....csYKPphYpDDsWVEFIElD.lD..DssEK..spGSDTpRLL......Spc.p.pcut.sh.GhKDDDSGRsSCY-PDl.-sDh................hL.ttp.sLLshctcstpp..ssspcus.....................sl.tst.cSsp.slps..Qhos..pohsNhDFYAQVSDlTPAGuVVLSPGQps+st.pspsst.............................cpE.hpp.hQh.h..s.ssuYhsEusA+phss.sP...pscst..shcPphsppc.a.ss....sssutsstoshh....uPsup..hPVsDYTsVp.VcS.puLlLNsss.....P......sscp.h	..............................................thap-DsWVEFIELDID....D..sDEK..TEGSDTDRLL......SsD.H.pKSl.sILGAKDDDSGRTSCY-PDI.L.-TDFpsuDhsDu..op.ht.ppL.KtEsDLLCLDpKN.ps....shsts..t...s.......s.csKPpsLl.utsESsp..Q...spT...hSNP...sSLA...N...IDFYAQVSDITPAGuVVLSPGQK.KAG....huQss.h.............................p.E..hss.sQtNa...hssAYFCEuDAKKCIshsP...+hEsps.phcPSFsQEDhYITTESL.TToA.hstss-h....sPsuE..hPVPDYT.olHhVQSPpGLlLNAsu.................sp.h.................................	0	1	5	14
+12608	PF12773	DZR		Double zinc ribbon	Bateman A	agb	Pfam-B_12 (Release 24.0)	Family	This family consists of a pair of zinc ribbon domains.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.35	0.72	-4.14	109	1392	2012-10-03 10:42:43	2010-02-16 17:13:36	2	114	823	0	495	1601	122	52.60	32	16.02	CHANGED	CspCtpt........ssss..upaCtpCGstLt..............................tt....CspCst....s.ssssspFCspCG	............................................CspCGt.t.......................sss.....ucFCspCG.stls............................................................................tt...hCs..pCup...........hs.ssspFCspCG.....................................................	0	174	347	430
+12609	PF12774	AAA_6		Hydrolytic ATP binding site of dynein motor region D1	Coggill P	pcc	Pfam-B_14 (release 24.0)	Family	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D1 unit of the motor and contains the hydrolytic ATP binding site [1]. 	21.30	21.30	21.30	21.40	21.10	20.80	hmmbuild  --amino -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.79	0.70	-4.82	3	2434	2012-10-05 12:31:09	2010-02-17 10:48:36	2	274	341	14	1635	2341	119	209.40	54	6.46	CHANGED	YSYEYLGNTPRLVITPLTDRCYITLTQSLHLlMSGAPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVVAVQVKCVQDAIRDKKctFNFLGEEISLIPSVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDP	.......................................................YuaEYL.G.s.s.s.R..LVITP..LT............D...R........C.Yl.....T..LspA....L...p...h...p.h................GG..u..P......tGPA.G.TG...........KTET.sKDLu+uLGh.s.............lVFN........C...S.-........thD......apu.................hG+hFp.G..L.uQ...s.....G..........AWuCFDEFN.RIplc.VLSV.......lA...p...Q..l.h............s......I........p..........p........A..........l............p........p.............p.............t....................p..................p.............a............................F........................G..............p..............p...............l.....p..L...s.....s...s...s.u...lF....I.T.M....N.P.................G....Y.................A..G.......R........o...E....L.......P-.......NL................K..s............LF.R..slAMhV......PDh.t.lIs.ElhLhSpG.F..h....p..u.c...LupK...hhsh.a.pLs.p..EpLS..p..............Qt....HYDaGhRA.lK.oVLhsAGshKR.......................................................................	0	696	866	1339
+12610	PF12775	AAA_7		P-loop containing dynein motor region D3	Coggill P	pcc	Pfam-B_14 (release 24.0)	Family	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D3 and is an ATP binding site [1].	20.90	20.90	20.90	21.50	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.83	0.70	-5.32	3	2098	2012-10-05 12:31:09	2010-02-17 10:54:55	2	245	278	14	1513	2001	100	255.70	31	7.07	CHANGED	FELDPElPLQAsLVHToETIRVRYFMDLLMERuRPVMLVGNAGTGKSVLVGDKLuSLssDuYLVpNVPFNYYTTSAMLQuVLEKPLEKKAGRNYGPPGTKKLVYFIDDMNMPEVDsYGTVQPHTLIRQHMDY+HWYDRpKLTLKEIHNCQYVSCMNPTAGSFTINSRLQRHFCVFALSFPGQDALSTIYNoILTQHLAhtSVSsALQKlSPsLVuAALALHQKIAsTFLPTAIKFHYVFNLRDLSNIFQGLLFSosElLKoPlDLlRLWLHE	.............................................................................................................t.l.l......V....PTh-TsR.h.p.a..llp.hh.........l.p.........p......p..c...Pl.lllGss.Go.GK.o......s.hl.........p....s...h.L.....p............p...l...........s...............p.....................p.......p......h.............h..................s....h.......t....l..s..........F...Su....t....T..o........u......t...........h..Q.......c.........h....l....-...s......h...l.......-...K......+................p...t............t...............s...........a..G..P......s....t...........u...........K.....+..h...l.l.Fl.DDlNMP.............t....h-p.YG...........sQ.........s.l.p.llRQhh-.h..s..s..a...Y......D...p.....p...c....h...s.......h..hp.l.h..........c......l...p....h.l.u.u..M...............s....P..s.......u.....G........R.....p...s................l.ss...........R...h....h..R+Fs.lhsls...hP..s..p..p..s.lp..pIa...u..s....l..........h..........p.......t....a.......h.......p.........................t..........a...............s..................p.....................l..p....p..h...s..p.....t...l...l....p.u.s.........l..p.l..ap..p..s...t...p..p..hL..P.Tss..K..HY....lFNL...RDlo+....l...hp.......................G.l..h.h....s............p.....p..h.........h....p...s................p.....ll.+LWhHE...............................................................................................	0	634	799	1238
+12611	PF12776	Myb_DNA-bind_3		Myb/SANT-like DNA-binding domain	Bateman A	agb	Pfam-B_16 (Release 24.0)	Domain	This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular Pfam:PF10545 seems most related.  This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  --amino -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.32	0.72	-3.36	73	836	2012-10-04 14:01:12	2010-02-17 10:57:23	2	29	65	0	554	860	0	91.40	20	25.51	CHANGED	pWs..sphp+hhl-lhh-phptGsp.......tssasppuWpp.lhppapp....psttpas+pQL+s+...hcpL+cpaphhpplhppss.............huWDsppptlsAs.cchWcph	................................Ws.st.pphhlchh.h.c.phptGpp.......ssshpppuapp.lhp....phpp.......phsh.p.h......s.p.pQlps+.......hcp.h+cpaph.hppLh..p..p.su.........huWDstp.....p.h.l.sAs..c..c.h.Wpp...............................	0	85	356	454
+12612	PF12777	MT		Microtubule-binding stalk of dynein motor	Coggill P	pcc	Pfam-B_14 (release 24.0)	Domain	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component [1].	24.00	23.30	24.00	23.70	23.90	23.20	hmmbuild  --amino -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.04	0.70	-5.70	3	2476	2010-02-17 11:31:39	2010-02-17 11:31:39	2	258	489	19	1602	2329	102	305.10	29	9.65	CHANGED	ERLENGLhKLQSTAuQVDDLKAKLAuQEVELKQKNEDADKLIQVVGVETEKVSKEKAIAD-EEpKVAVINcEVocKQKDCEEDLAKAEPALLAAQEALNTLNKNNLTELKSFGSPPsAVlNVoAAVMVLhAPsGKIPKDRSWKAAKVsMuKVDuFLDSLINFDKENIHENCLKAIKPYLsDPEF-PEFI+oKShAAAGLCSWVINIVRFYEVYCDVEPKRQALpKANAELsAAQEKLAtIKAKIAELNANLAcLTApFEKATADKLKCQQEAEATuRTIoLANRLVGGLASENVRWAEAVpNFKpQE+TLCGDVLLITAFVSYlGaFTKKYRs-LhERhWlPYL	.........................................................................................................................t..hpsG.LpKLtpsttp...Vt..thptpL..t.......p.....L.t....tp.t.....p.s.p.t.h...h.t...l.....t.......h...p...p..t..t...................s..p......p..p....c..t.........s..t.......t...p.....t............t......h...t............t.t....t...h...............t..t...h.......p.......p.......p.......s....p.......t.......-L.t.pA....Ps..L..p.t..A...tA............Lp...s...l..p..t.........t.sl..sp.l+uhtp.......PP..t.h.V...t.......hl..h..p.u..V..............h........l.l..............h...............t............................................................................................p..........................s............W.......t..s..u..+.....t....h.........h......s.....c....................p..............F...L....p.s.L...h...s......a....D...K......-....s...I..s...p...p....h..h...c..t.....l..p..t...........a......l..p...p..s..-....F.s....s....c............h...l...p..ps..S...t..Astu.Ls....pWVhA...h...t.Yt.c......V.h.+.....V.......t....P....K.+..p...p.......L....t...p...s...p.......tp....L.......pt....stp.p...L.p..ph.ptp.Lpp.l.pp...pltt.Lps...pa.c..p.t..hs...c..K....p..pl...pp...........p.............h.c........h.s........p............p..+......lpp..App...LlsuLuu..E+.........R.........W...................pp....s....s...p....ph.pt.ph..ppL.sGDsLl.......uuu..hluYhGsFstp.aRpphhpt......hhh................................................................	0	659	838	1298
+12613	PF12778	PXPV		PXPV repeat (3 copies)	Bateman A	agb	Pfam-B_15 (Release 24.0)	Repeat	This short repeat is found in multiple copies in a variety of Burkholderia proteins. The function of this region is unknown.	20.20	15.50	20.20	15.60	20.10	15.40	hmmbuild  --amino -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.40	0.72	-4.25	7	141	2010-02-17 11:33:22	2010-02-17 11:33:22	2	4	87	0	42	110	3	22.60	66	23.66	CHANGED	Ghs...APVhs..tPAPVhl.....APtPslV	...........GsP....APVYV..tPAPVYVAP.tPslV.	0	3	14	32
+12614	PF12779	YXWGXW		YXWGXW repeat (2 copies)	Bateman A	agb	Pfam-B_15 (Release 24.0)	Repeat	This short repeat contains the motif YXWXXGXW where X can be any amino acid.  It is generally found in 2-5 copies in short secreted bacterial proteins. Its function is as yet unknown.	18.00	5.00	18.10	5.00	17.90	4.90	hmmbuild  --amino -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.38	0.72	-3.97	88	527	2010-02-17 11:41:07	2010-02-17 11:41:07	2	11	179	0	276	526	23	23.20	37	20.84	CHANGED	shhYlapsGhWah.....u.sa.sGsWhh	...........sYlWssGaWth.........taha..hsGhW......................	3	66	118	207
+12615	PF12780	AAA_8		P-loop containing dynein motor region D4	Coggill P	pcc	Pfam-B_14 (release 24.0)	Domain	The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor [1].	22.90	22.50	23.10	22.60	22.80	22.40	hmmbuild  --amino -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.65	0.70	-5.42	3	2160	2012-10-05 12:31:09	2010-02-17 12:48:52	2	240	286	14	1532	2037	96	247.80	35	7.05	CHANGED	YNEVNAVMNLVLFEDAMpHVCRINRILESPRGNALLVGVGGSGKQSLoRLAAYISSLDVFQITLRKGYGIPDLKlDLAolClKAGVKNlsTVFLMTDAQVADE+FLVLINDLLASGEIPDLFuDDEVENIISuVRNEVKShGLsDTRENCWKFFIDRlRRQLKVlLCFSPVGosLRVRSRKFPAVVNCTAIDWFHEWPQ-ALVSVShRFL-ETEGIcs-VKpSIScFMAYVHTSVNEoS+lYLoNERRYNYTTPKSFLEQIKLYQSLL	...................................................h..sLV.lFp-AlpH.................ls.RIsRllc.p.P.p..G.ps.L.LlG.V.GG.SG+pSL..oR.LA.u.....a.hs..s.h.p..lF..QIp.....l.........s...+..s..Y.s.hs-....a....+...-D..L+plh.tp.....u...............G...h.....c....s...p.t.h.....sFLhsD...spl.............h.c....E.u..FLE..l.Ns..l....L.so.....G..............E........lP.s............LF...s...t.DE....h.p.p.l........h............s..............t........h.....+....s.......t..s........p...................p....t..................s.....h...........s.....o.....t..........p......s.......l..a......p.aF.....l.p.+...........l+.p..NL.....H....l...V.Ls..h..S..P.....lG..c....s...h.R.s.R....h.+..........pFPu.........Ll..N..ss.sIDW..Fp..p..WPp..-ALh..p...V.................u......p.................p.................a.................L....................p....................p.................h..............p...................h...................h..................p...........................p.................h.....................c....................p..........t......l......s.....p...........h...hsh.....h..........H.t.sl.t...ph.s.t....p..........a.h......t..p......p..R.hsa.sTPpsaLchlp.hatth............................................................................................................................................................	0	634	798	1248
+12616	PF12781	AAA_9		ATP-binding dynein motor region D5	Coggill P	pcc	Pfam-B_14 (release 24.0)	Domain	The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution.  This particular family is the D5 ATP-binding region of the motor, but has lost its P-loop [1].	22.20	22.20	22.20	22.30	22.10	21.90	hmmbuild  --amino -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.61	0.70	-5.50	3	2170	2012-10-05 12:31:09	2010-02-17 13:30:02	2	225	287	14	1548	2035	88	214.80	38	6.23	CHANGED	MLTDDADVAsWNNEGLPSDRMSTENATILuNCERWPLMVDPQLQGIKWIKNKYG-DLRVIRIGQKGYLDlIEQAISuGDTVLIENlEESIDPVLDPLLGRNTIKKGRYIKIGDKEVEYNPKFRLILHTKLANPHYKPEMQAQsTLINFTVTRDGLEDQLLAAVVApERPDLEQLKSDLTKQQN-FKIlLKELEDSLLSRLSSASGNFLGDTALVENLETTK+TAAEIE	.............................................................................................................pltpWp....p..GLPs.DphSh.-N..ul........I...l.......p...p.......u.......p............R.......a....P...L.h...ID.PQ...sQ.u..hc.W.I......K.......s................h.........................p.........s.....................p...................L......p........l...h.p.....h......s..p...p.............s...a...h..c.....p....LEpulphGpslLlEs...l..t.E...p..l....DP.sL......pPl.L..t.....+...p.....h....h.....+.....p.....G...................p.......h.........l................+..l....G...D..p..p..l-as.s.s.F+la..loT..K...L....s..N..P...c.Y.....P...E..l.p....s.....+...s.ollNFs.lT......................pGLE..............-QLLuhV..l.tp.E.+P....-L....E..c.p.+sp.....Llh..p.t.....s..................p.K.h...pL+pLE-plL.ptLs....su...............p..G...s...lL......-..D.p....pLl.psLppoKtput-l......................................................	0	635	802	1257
+12617	PF12782	Innate_immun		Invertebrate innate immunity transcript family	Coggill P	pcc	Pfam-B_9 (release 24.0)	Family	The immune response of the purple sea urchin appears to be more complex than previously believed in that it uses immune-related gene families homologous to vertebrate Toll-like and NOD/NALP-like receptor families as well as C-type lectins and a rudimentary complement system. In addition, the species also produces this unusual family of mRNAs, also known as 185/333, which is strongly upregulated in response to pathogen challenge [1].	26.90	26.90	26.90	31.50	21.60	26.80	hmmbuild  --amino -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.36	0.70	-5.20	9	746	2010-02-17 14:14:11	2010-02-17 14:14:11	2	4	2	0	6	908	0	162.80	58	101.52	CHANGED	MEVKVTLIVAIVAALAISAHAQRDFNERRGpENGRERGQGtFGGRPGGMQMGGPRQDGGPMGGRRFDGPsSGAPQ.........................MDGRRQNGGPMGGRRFDGPcFGGSRPDGAGGRPFFGQGGRRGDGEEETDAAQQIGDGLGGsGQFDG.GRtHHGHRQG.PQDpsEEQPFGQRN.SSEEDGRPHPHHHt......+HHpHH...........................................+RNHTEGHQGHNETGDHPHRHHNKTtDtDQDRPMFEhRPFphN...PFGRKPFG-RPFsRRNGTEEGSPRRDGpp+PaGNRGRWGENESEEKE+PTTESlTTSSPsEVVclAhN-	..........................................................u.RQDGGPMGGtRFDGPt.GAPpM-GRRQsGGPMGGRRFDGPtFG................................................................................................................NpTEGHQGHNETGDp.............DQD+.h.-.RPFhhN....FGRKPFGs+.F...................................................................................	0	6	6	6
+12618	PF12783	Sec7_N		Guanine nucleotide exchange factor in Golgi transport N-terminal	Coggill P	pcc	Pfam-B_13 (release 24.0)	Domain	The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF [2].   	25.40	25.40	25.70	25.40	25.30	25.20	hmmbuild  --amino -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.06	0.71	-4.82	70	1211	2010-02-17 14:38:16	2010-02-17 14:38:16	2	22	295	0	824	1186	8	143.70	24	9.89	CHANGED	hshhtpDAhhlFcsLCpLs...p..sppp..shh....tthpschhuLcLlcslLpspts.l..Ftp...............chlp.sl+phLs.sLl+sssS.sh.hslhphshcIhhhLl.pph+stLKhElElhlshlhh...lL.........-.pst....shp..pKhlsLchhpplsp-Pphlh-lYlNYDC-.s..ppNlh	...................................................................................................h..shh.lFcs.LspL......................s...........t...tt...........................................t.................hs+hhuLpLlps.hLps...tss..h..ht..................................phht.hl......+p.lsh....tLhp........hs...........s...s..........................slh......t.h.shplhh.hLl..pp..h............+s.hL+..h........ph.E.............lahp.lhh.ll..............................................pspp.......sht..........p+.h.sl.p.........hlpp.......lh.t....p.s.....p.hlhphahsYDsc.t..ttslh...................................................	0	286	456	677
+12619	PF12784	PDDEXK_2		PD-(D/E)XK nuclease family transposase	Bateman A	agb	Pfam-B_5 (Release 24.0)	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily [1]. These proteins are transposase proteins.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  --amino -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.27	0.70	-5.19	73	2282	2012-10-11 20:44:46	2010-02-17 14:49:08	2	7	653	0	358	1886	49	177.50	20	76.61	CHANGED	spsDauFK+lFGsc.t.NcclLlsFLNslLp..tpppIpclc.llss.......c..t-hts-Ktull....Dlhspss....sGppllIElQhppppsFhcRsLYYhu+shsp...Ql.............p.pG...pt.Yp............pLppllsIsIls.Fshhts.........p....ch+sshplh-ppspp..hhh.........cclphhalElsKFpppppcppsp........h-cWlhalcstsphppt.h.h.....psshhccshpthcphshscc-ht..sY-p+.chhh....Dppsslcpu	......................................................hhp.hh.t.........p.thh.h.t..hlpshLt................t...tlp...lp....h...s...............................p........t.s........+..shh..............Dlhsp.p........sGp..h.lEh.Qh.p........p......p.....t.............h..h........p.Rhh....aYhsphhsp...pl...............................p...pG.......t...Yp..........................pl..t..shhI..l...hs...h.hh.t..................t.............thhp...h...h......p.......p....p.t.........h..............p...t..hh..lph..h.................................hh..hh.......................................h..h...t.h.....s..................................h..............................................................................................................................................	0	126	250	271
+12620	PF12785	VESA1_N		Variant erythrocyte surface antigen-1	Coggill P	pcc	Pfam-B_22 (release 24.0)	Family	This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.	21.40	21.40	33.10	21.40	19.60	20.60	hmmbuild  --amino -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.95	0.70	-5.52	42	227	2010-02-18 13:21:03	2010-02-18 13:21:03	2	2	1	0	141	227	0	260.00	32	38.40	CHANGED	AAVTDLLQSVpLEYH.............GYQG-sK.......tssssKGAsccpVs..c+LNGLFSLVQGLGGTAVVRTYIDQLAQVLSALVGWS+I-KC......................tssspCpssststp........................................................HGppss....CcYLcDVctss.sCscCGCMKWsVsp...spscGppLGRtCTRCpsSGsstt......CpCusuust...Cou.spc.CKCAhsGKC....CKCC.....Cpspss.t........Cptpt............uChpppp..............-....sYhSAYsp...................h.ttttht..hpshWssLhp.s...............ssSp..+RHpCARILLGSVCLIWSGlTYMYWTGKYtpoSPRWNNHILDGSGLDDGTLSQWLQALGFP+-MLNNsGPtNRLDuVIWDGhpsKLaLGFscsushss...s.upDsssNThRsPsGMNYAGaIHTscRsuFsss.AsVFppsssss........ho-psppKpGALaKLYILSCAYFTGL....QKK....................puss+TPKTIREILYWLSALPYSpAY.clLcHuKc+L	........................................................................................................................................................................................................................................................................................................................................................................................................C.tptsss.....sts...cpCpC...s.h..s.G..t.............................................................................................................................................h..hAp.hLGslsLIaSslo.h......s..........s..t....hWpt................................tahtshGas...hp.........................................................................................................................................................................................................................................	0	141	141	141
+12621	PF12786	GBV-C_env		GB virus C genotype envelope	Coggill P	pcc	Pfam-B_19 (release 24.0)	Family	This the envelope protein from the ssRNA GB virus genotype C.	20.40	20.40	20.40	20.80	19.70	19.70	hmmbuild  --amino -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.75	0.70	-6.01	6	568	2010-02-18 13:22:19	2010-02-18 13:22:19	2	10	6	0	0	453	0	191.40	59	45.18	CHANGED	Rls.lPNLTCslcCDhcash.uhsl.....Dh.WshchlhcLPh+LW+GlsuhssLhllVlhhLlLEQRLVMsFLLLhssGpApss..............hapuCpCth.GuRsP.Pshpsh.RGNuTllC-CPFGpMhWhPsLCuGLsW+DGspc...GsspsLPhsCPcpVhGoloVhChWGSAaWhWRhG...shVcLacpLP.tSALCTFauhspucpsaPt.VssLospGsPCASCVVDpRPspCGsCVRDCWEpsGs...sFccCGlGsRlTccLpAVlVcGGsESploTPhGERP+YhuQHGsGsaauAVpthuhshTVoclGGYWHAltCPs.-assGsLPchIPGhPVNACls..scsu+shuuW.APGGaYAPlFT+CNWPpssGVcVCsGFAaDFPGc+sGFIHV+GuhQQlhuGshtssPpWLL	..................................................................................................................................................................uluWGDPIs....tGQsp..........aGusSVss.......................................................................................................................................................................................................................................................................	0	0	0	0
+12622	PF12787	EcsC		EcsC protein family	Bateman A	agb	Jackhmmer:Q186V8_CLOD6	Family	Proteins in this family are related to EcsC from B. subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system [1]. The function of this protein is unknown.	27.00	27.00	27.20	27.30	26.70	26.80	hmmbuild  --amino -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.46	0.70	-4.98	47	901	2010-02-18 14:38:34	2010-02-18 14:38:34	2	5	716	0	203	677	35	219.90	21	83.19	CHANGED	a.pptlp-lppWcpc...p+csthhp+hs+hs.phl....scllPptlpctlssslc....phsphlhsGupalh................................................shpslpphsLpphDplscchhpthpphAsspGAsTGsGGlhhhhuDhPllLulplKhLa-lAhhYGaDsc-hcERlFILplhQluhS.s.tt+ptlhpplpp..........acttpp....t..splp..s....W+ph.ppYRD.hshtKhh........QhlPslGhlhGAhsNhphlcclu-sAhhhY+hRhl	....................................................................................t.....................................................................................................................................................................................t...h........p....h....p..t..h...h....p...p...h..ht..p..ppthA..sspGus.....oG.......h.......G....................Gl..h...........s......h.s....s....-lP.......s....hl....s....lt....h....+....hlt........plAp.hGaD.l...s.c......cpph.hhLt.l...h.t.h...uht....s.p......tc..p..t.h.hth.h.tt...........................................htt.t.t.................t..t..hp...h.s.......................hcpltpp....h...t...s.l...s....h....p...phh.........................phlP.l.l.Gus.lGAssNhhhhpplschApttathRhl...............................................................................	0	69	145	168
+12623	PF12788	YmaF		YmaF family	Bateman A	agb	Jackhmmer:Q181M3	Family	This family of proteins contain 6 HXH motifs and is named after the B. subtilis YmaF protein.\	 It seems likely that these are involved in metal binding. The function of this protein is unknown.	27.00	27.00	27.30	27.40	21.80	26.90	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.59	0.72	-3.84	10	130	2010-02-18 16:13:56	2010-02-18 16:13:56	2	1	90	0	33	113	0	90.10	43	77.47	CHANGED	+hQoHsHEFtuSTchAE-s-.-cHNHRhAGVTGpAI.h.G.sSHVHKI.pspTDFF.DHFH-lClTTGPAIhl.usGKHIHLVpGpTTlNDGHpH-ahFTTLI	.........................pHsHEa.uSTphsp.t..........p.c.HNHRhuGVoupsI.h....G..ssHVHpl.p.s.pTDF.h.sHaHhIs.shTGPAIsl.uss+HlHhlsGhT..ohsD..G..HpHcahhsT.l.....................	0	15	24	28
+12624	PF12789	PTR		Phage tail repeat like	Bateman A	agb	Jackhmmer:Q181M3	Repeat	This family largely contains proteins from the eukaryote Trichomonas vaginalis.  These proteins contain multiple HXH repeats. Some proteins in this family are annotated as having phage tail repeats. The function of this family is unknown.	27.00	7.00	27.00	7.00	26.90	6.90	hmmbuild  --amino -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.66	0.72	-4.13	16	1947	2010-02-18 16:37:43	2010-02-18 16:37:43	2	34	108	0	1744	1922	24	47.00	41	23.61	CHANGED	chScKsHTHoIusITsLQETLspKuDhsHTHTIANITNLQ..ETL..pp..DVGHTHTIusITN	....................................HtHsI...usIssLp-oLsc.Ku.........Dh..s...........H..T.H.s....................................................t..............................	0	1732	1740	1742
+12625	PF12790	T6SS-SciN		Type VI secretion lipoprotein	Coggill P	pcc	Pfam-B_27 (release 24.0)	Family	One of the virulence mechanisms of E coli is the production of toxins which it produces from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to upto more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as ABC transporters (type I), type IV pili (type 2), flagella (type 3), or conjugative machines (type IV). The type VI secretion system (T6SS) is present in most pathogens that have contact with animals, plants, or humans. SciN is a lipoprotein tethered to the outer membrane and expressed in the periplasm of E coli and is essential for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation.	21.60	21.60	21.80	21.70	20.60	19.30	hmmbuild  --amino -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.49	0.71	-4.57	149	1326	2010-02-18 16:39:03	2010-02-18 16:39:03	2	3	848	1	228	812	20	148.70	26	83.77	CHANGED	slhLuGCu........................s..h.tpssplslslpAssslNsst...pGpssPlhl+lYpLcssssFpsu-a.sL..hps...sppsLus-ll.spc-hh.ltPGpptp.ls................hshspsspalGllAtapchs..pup.W+hlhslsttt.........................pht.....lplplsspsl	.............................hlLsGCu.......................................................tsu....ppspplslslhupsslNsss...puc...ssPlhlplapLpssstFpsADa...sl..tss.........tpssLssshl.s.ppchh.LhPGp.t.pp.ls................hpls.p.p.spalGVl.Atapc.s...tsp.W+hlhpltsts.........................chtlhlplpppt..........................................	1	31	88	154
+12626	PF12791	RsgI_N		Anti-sigma factor N-terminus	Borovok I, Coggill P	pcc	Borovok I	Family	The heat shock genes in B. subtilis can be classified into several groups according to their regulation [1], and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes [1]. Regulation of sigma factor I is carried out by RsgI from the same operon, and this N-terminal cytoplasmic portion of RsgI ('upstream' of the single transmembrane helix) has been shown to interact directly with Sigma-I [2].	21.40	21.40	21.50	21.40	21.00	21.10	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.58	0.72	-4.30	52	279	2010-02-18 16:43:53	2010-02-18 16:43:53	2	6	205	0	71	235	0	56.00	24	13.15	CHANGED	lclcccpsllhTscGcFlcl+ppss..hplGpcI.hpppshhphtpthh..hhhhshshh	.......h-lcccpsllLTscGcFlp.lKp+sc...hhlGcEIphsppchht..pptth...hhhh.h...sh................	0	35	63	67
+12627	PF12792	CSS-motif		CSS motif domain associated with EAL 	Coggill P	pcc	Pfam-B_29 (release	Domain	This family with its characteristic highly conserved CSS sequence motif is found N-terminal to the EAL, Pfam:PF00563, domain in many cyclic diguanylate phosphodiesterases.	21.60	21.60	21.70	21.60	21.40	20.80	hmmbuild  --amino -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.17	0.70	-4.99	138	2685	2010-02-19 09:08:36	2010-02-19 09:08:36	2	3	774	0	211	1380	30	205.10	21	40.43	CHANGED	pphppphpshuppslpph-p......llsps.ppshsph...shssps..Csps.hhtLpphshtt.al+slsll.cssplhCSShh.G.h.shshs...s.h......h......shplhhhtssshhsspshl..hht.ts....hsssushsslssthh....hhthh..phsshhlt.......h.spthlttts....t.h.ttssh..........hhhphpSsc.....ashslh.......stsststhhphhhphhhhhl	..................................p..hppchsshuspshcph-p......lhtph.ptstpth...t.htsps...Cs.A.thpLpphutth.hlcslshl...cssphhCSSlh...s...t..shs...h....s.h.ssh..........hp.......ssplhl.hs.sssh..h.sp..hl..hhh..pss..shhssusa........stl.p.shhht...l.hsh.s.phssssls..................l.spshlptts......shhhp.sth...............htpspssc.....hslslh.......lhssstth.thaat.hhh..h..............................................................................	0	15	45	130
+12628	PF12793	SgrR_N		Sugar transport-related sRNA regulator N-term	Coggill P	pcc	Pfam-B_33 (release 24.0)	Family	Small, non-coding RNA molecules play important regulatory roles in a variety of physiological processes in bacteria. SgrR_N is the N-terminus of a family of proteins which regulate the transcription of these sRNAs, in particular SgrS. SgrR_N contains a helix-turn-helix motif characteristic of winged-helix DNA-binding transcriptional regulators. SgrS is a small RNA required for recovery from glucose-phosphate stress in bacteria [1]. In examining the regulation of sgrR expression it was found that SgrR negatively auto-regulates its own transcription in the presence and absence of stress, and thus SgrR coordinates the response to glucose-phosphate stress by binding specifically to sgrS promoter DNA [2].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.38	0.71	-4.08	49	1737	2012-10-04 14:01:12	2010-02-19 13:52:54	2	2	824	0	137	981	7	113.50	39	20.26	CHANGED	+lhppapRLapths.....spstpsTLsElA-hLaCScRHsRsLLppMpptGWLsWpspsGRG+RSpLthhhsspplptphAcchlcpGchcpAlplls..cpttltplLppphGtphppu	...................h.pQa.RLaQtss........GcsppsTlsELA-hLhCScRHhRoLLpphQ-tGWLpWpupsG....RGKRo.pLpFLh.os..sLppphsEchLEps+hppllpLlt...s......tuplpphL.sahGtpapps......................................................	0	24	45	93
+12629	PF12794	MscS_TM		Mechanosensitive ion channel inner membrane domain 1	Coggill P	pcc	Pfam-B_24 (release 24.0)	Domain	The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this domain is one of the inner membrane domains.	23.40	23.40	23.90	23.50	22.70	23.30	hmmbuild  --amino -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.04	0.70	-5.83	72	1372	2010-02-19 14:00:30	2010-02-19 14:00:30	2	5	800	0	153	777	52	322.70	42	30.04	CHANGED	hpshlhhlhhlLlhhhll....hh+pphpptLpphspclGplppDshhhT.pulhhollhuLPhslhhhhsGhhlt.hs.hsts..tslusulhthuhh.hhlathhhphhpspGlhhtHFphsppplpphp.+hhphhhhhllsllhhhshs.....pthssphhpsslGplshllshhhlshhhh...slhctshs.hts......t...phlppllhhhlhhsPlhlhlhshhGYaaTAhtLht+L.tSlhlhhhhhllapllhRhhhlppRRLAacRApt+Rpp..hh......pEt...t.ssc..........hp.l-.Esslcl-pIspQSL+Ll+hlLhlhhlsslhhlWu-llss.huaL-s..IsL.W	...........................h....LshhshLllsGh.h....aptpahptalp+hAutVGplp.pDp.hhT.+slhhsllhAhPlsllhhslGhhLh.ph...hslushlhshspths.h.hhVhhlCh.phhcsNGlhltHFGhPcppsu+hh.R.hlh.hhhllPLhhh.lhh.............-..s..+.h.sssL.GphshllhhhhlAllsh...slp+tuh..h.s..............phhph..lhhshlhhhPlshhlhoAsGYhhTu.tLhuRh.poV.hlhhlh.llYpslhRhh.lttRR..l.....AacRAhtRRtp..hl......cE.........usp..................................uh.ss-.EsplsL-tIstQoLRlsp.llhhlhhl.hhslWS-lhos.FuaL-s..IoLW..............................	0	21	56	106
+12630	PF12795	MscS_porin		Mechanosensitive ion channel porin domain	Coggill P	pcc	Pfam-B_24 (release 24.0)	Domain	The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.	31.40	30.50	31.40	32.60	31.30	30.40	hmmbuild  --amino -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.73	0.70	-5.05	69	1277	2010-02-19 15:07:52	2010-02-19 15:07:52	2	3	738	0	127	672	19	235.70	40	21.69	CHANGED	ppLcplpp..ppssspppthlpsLppsLshLschcctcpcspphpptlsshPpphcplpppLpshpss.......sstshhsshohspLEpplsptpspLtphpcpLpphpsplhplpsp.pphpsphspsppplppIpppLpsh.sss....sslppuppshLpsE.shlpsphp.hchphhussshQ-Lh..phpp-h.hptchppL-pplQtLpstlNppRhppuEpslccspp.tpp..p.sptsshlppp	....................ppL-phpt.....hpst.pt.l.psLpssLssL-chcpstEcspQhpphlsphPchhpphpA.pLssL.cs...........EsRpl.sshShcpLppclhQs.spL.s....tppphtp.psplhplpsp.ppl.pt.hsAppQLppIcp....RLsu....h....ssGp.........ssLp.uQphhhQu-pAhLpAplDp.chu........ussshQ-Lh..............phpp-h.sptpSppL-t.LQhLpptlNSpR.p.uE+shppsp..sEs..phphs.hlhpp................	0	14	42	86
+12631	PF12796	Ank_2		Ankyrin repeats (3 copies)	Bateman A	agb	Jackhmmer:Q183I8_CLOD6	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.45	0.72	-3.64	620	110723	2012-10-02 12:10:21	2010-02-22 09:13:01	2	6024	2889	200	69620	109701	6937	89.50	23	36.39	CHANGED	Lh.hAsp...p..s..p.........h..p.h..........l.c....hL.....................l...p....ps.......s.....shs.....................ps...............................................sL.h......h.....A................s....................t..t...up.....h...........................................................................c..hlch.........L.lp...............................................................ts...s.s..h.............stp.......................tupTs............................Lhh.............A..........st..................psp...h...c..hl.........c.h.Ll.p.p...............s..s.sh.s....hps	................................................................................................................................................................................................................................................................................................................................................................................................h.t.........h....................................................................h.....t.......t..................s...phs..........................................spT................................................................................................sL.p.........h..........A............................u............................................t..p....G...p.....h..................................................................................................................................................................................................................................c....h....l.c.h..........L...l.p...................................................................................................................................................................................................p.G.....A....s...l...........................stps...................................ppGt.T..s........................................................................................L.p.h................................A............................s.p................................................p.u..p.......h....c.......l.....l.................c..h...Ll..p.t..........s..s.p.......................................................................................................................................................................................................................................	0	33547	42383	56433
+12632	PF12797	Fer4_2		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q184V9	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  --amino -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.65	0.73	-7.77	0.73	-3.72	423	1399	2012-10-03 08:56:42	2010-02-22 11:31:53	2	39	752	0	175	6075	978	26.70	70	12.06	CHANGED	hthhhs....ts..p...C...hs...C..tt..C...ht..sC........Ps	...........Y.GFFID.......SS..RCTG...CKTCEL..AC........KDh+sLss.............	0	59	106	145
+12633	PF12798	Fer4_3		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q184V9	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  --amino -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.94	0.74	-7.15	0.74	-2.97	447	625	2012-10-03 08:56:42	2010-02-22 12:42:34	2	99	466	0	231	9841	2305	17.30	47	7.78	CHANGED	C..ht..C.............stCh.psCP..t...ss	....................C..hp...C......................................suCVsAC..s..........	0	69	134	183
+12634	PF12799	LRR_4		Leucine Rich repeats (2 copies)	Bateman A	agb	Jackhmmer:Q187Q2	Family	Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions.  Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.52	0.72	-4.27	569	21961	2012-10-02 21:32:02	2010-02-22 13:07:11	2	3572	1441	188	8913	43842	1514	44.60	29	11.83	CHANGED	p..sLppLp......Ls.p...N......p....l...p...s.....l..s.....s...........l..p....s........L...s....p....LppL.....s...l...s.........p.....N.p..l....p.......s..........l......s...s...l...p....p	.................................pLptLs...............Ls.s....N..........p....l......s.....s.......l..s........................s..............l..u.....p.........................L....s.......s....LppL...s...L...s......................s.........N.p..l.........s.........s..........l.....s.........................................................	0	2700	5198	7123
+12635	PF12800	Fer4_4		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q184V9	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	24.00	10.00	24.00	10.00	23.90	9.90	hmmbuild  --amino -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.47	0.74	-7.83	0.74	-3.15	187	4289	2012-10-03 08:56:43	2010-02-22 13:24:58	2	168	1372	4	663	24462	7195	20.30	39	10.05	CHANGED	t...sp......C.....h.....p......Cs...t.....Ch.ps..Cs.................hp	....................tpC..........l.......G..................C+.........s.........CphA..C...sh....................	0	214	424	548
+12636	PF12801	Fer4_5		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q189G9	Domain	Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	22.00	0.00	22.10	4.40	21.90	-999999.99	hmmbuild  --amino -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.76	0.72	-4.17	217	6537	2012-10-03 08:56:43	2010-02-22 14:38:41	2	113	2159	0	1700	6678	530	48.00	21	19.61	CHANGED	hshhhl.lhhh.hllhhshl.......hGR.haCuWlCPhGslp-hhtp.........hhppph..thp	.......................h...hhh.lhhh..slhlhshh........htR..saCualCPhG.slhslhs.................................................	0	631	1249	1513
+12637	PF12802	MarR_2		MarR family	Bateman A	agb	Jackhmmer:Q17ZV2	Family	The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR.  A large number of compounds induce transcription of the mar operon.  This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.62	0.72	-4.30	266	11347	2012-10-04 14:01:12	2010-02-22 15:12:01	2	65	2832	42	3627	27482	2684	60.70	22	32.41	CHANGED	h.Gl..s..hsphtlLhh.ltptss....................h..ohsclsc..thtlsc.sslsphlppLtp..pGll.........ppp..ts.t.DpRt	........................................................tl.s....tph.pl.L....hh...L...t...ppss......................................................h.....shs-Luc......ph.tl......sp.sslophlpcLpp...pGLl.........p+p......ss.p..DtR................................................................	0	1112	2404	3087
+12638	PF12803	G-7-MTase		mRNA (guanine-7-)methyltransferase (G-7-MTase)	Coggill P	pcc	Pfam-B_40	Domain	The Sendai virus RNA-dependent RNA polymerase complex, which consists of L and P proteins, participates in the synthesis of viral mRNAs that possess a methylated cap structure. The N-terminal of the L protein acts as the RNA-dependent RNA polymerase part of the molecule, family Paramyx_RNA_pol, Pfam:PF00946. This domain is the C-terminal part of the L protein and it catalyses cap methylation through its mRNA (guanine-7-)methyltransferase (G-7-MTase) activity [1].	25.00	25.00	31.00	29.90	21.10	21.00	hmmbuild  --amino -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.86	0.70	-5.29	29	388	2012-10-10 17:06:42	2010-02-22 16:14:03	2	3	87	0	1	397	0	319.70	39	14.47	CHANGED	phuaplYYhRlpGcpphh-YlhshLpRhstssLsslusslSHP+laRRhhssGllpPhpuP.Lso.sahthsh-hlhtuhcpaLs.lhsG..hchphllspsspshls-RhtslhAR+LslLssLassspphPpI+GLsshEKCtlLTcaLpptshts......hsshphslps.plssasssLhYlpRpslppIRhc...s.....s.hhltphhcshsh.ptshtttps..........tsshppssph..hp.....l.spspthpph.hsssttsshp................pHhhRhlGlsSTShYKAlplsphlpphh..pGspLaLuEGSGAhhohhchhlsss	.........shuYQlYYLRlpGhpsIl.Yhsshh+pMsshllsslusTlSHPhIapRhhssGllp.stu.pLAspDahchuscllhoCscphlssLhsG..sca-lLhsss.-DsLs-+h.plluRhhClhssLauss+chPpIRGLospEKCulLT-aLhu-Ahps......tsppspsIhsPpIhsaPusLaYhpR+SLshIRtRp........csshls.hh.sp.sllc.p.spshhuphpt.....shs+pssuhl.ths....Lssss.phcthh..psps.psh.............t..lpahFRsIGhsSSSWYKAsclhol.chpts..pcGsuLYLuEGSGAhMolhEhhlstp..	0	1	1	1
+12639	PF12804	NTP_transf_3		MobA-like NTP transferase domain	Bateman A	agb	Jackhmmer:Q188E0	Domain	This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.11	0.71	-4.16	571	9345	2012-10-03 05:28:31	2010-02-22 16:22:27	2	87	4058	75	2565	24779	11854	170.00	18	55.35	CHANGED	ullLAGG......p...u......p.....Rh...........G.......s...........s.........Ks..l........l.h.......s.G.....p...........s...llp+sl.ptl............psh.......h..s.............................plhls....s..st....p.............p..h.h.....t..................................h............t..th........s.....ht....h.....lt-........t......s..t.........GPh....uu...ltsul.....................................p....t....s........p.....s...sh.............ll..lhssD.hPh...lsssh.lppLhpth...............t......p....s...........s..s.......h..ss..st.t.p.........s..p..h.......................................................hp.P.l......l..h.....stp...h...h...........st.lp....p.h........t..s....s.........p..u......h.......+p...ll.p...............p.h.....t....ps	................................................................sllL.A.u...G.......p......u.......s.....RM....................................t.........s.......s.................Ks..L........hpl........sG.....c......................................s...hl.p+..sl.....cs.h.................p.p.h.....t...s..s....................................clh..ll......s......sp......c.................p....h.t....t.......................................................h..h...............t..t......................s.......lp.....h...........l.h.s.................s..........p.....h.................G.s..h........t..u....l...h...s....u..h............................................................pt......h............t.s.pt........................h.l....l...h....s......u.D....h.......P..h.............l.....s.....s....p.....h.......lp..p.L...hp.th........................................t..........t..s........h....h..h.......h...............................................................................................................................................................................................................hhthhh......................................................................................................................................................................................................................................................................	0	846	1696	2182
+12640	PF12805	FUSC-like		FUSC-like inner membrane protein yccS	Coggill P	pcc	Pfam-B_45 (release 24.0)	Domain	This family has similarities to the fusaric acid resistance protein family. The proteins are lodged in the inner membrane.	20.60	20.60	20.60	20.90	20.50	20.50	hmmbuild  --amino -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.66	0.70	-5.48	75	1796	2012-10-02 19:04:43	2010-02-22 17:07:20	2	5	1161	0	248	1140	37	272.10	36	38.74	CHANGED	sLhhoLlsFhluohslplhhsa..shhFslslhhsoFshshLGAlGpRYuoIuFuoLllAlYThlshs.........ts.thatpP..llllsGAlWYslhollhphlaPppPlQcsLApsappLusYLcsKusLF...cPs.ppppspphphtLAtpNspllsslNps+psLhpRht.us+tp.ssp..+hLphYahAQDIHERsoSSHh.pYppLpcthp.pSDlLaRhp+llphQupuCpplApulhhpp.Yp......asschptuhpplpsuLph.tpp...psttpt.hhtsLptLhpNLps....l-ppL	......................................LIlshhsFhluShss...pLL.h.s.h..shhhslsL.oh..T.hs.hhlluslGt.+a.Aplu.huuL.l.lA...IaThhssu.........h.....h.apps....llllhGulWYslhshhhahlas...pPlp-sLupsYcpLAc.YLEs.Kuph.a.....s..pc.....s-....sptslhsLs.h.tp...t.pl.hst.lsQs+tp..lhhp....us+sppss+..RhL+hahhA.D.laE+hS....uSph.p.Ypplp.ch.hc..+S-lh.hh..hpphhph.ut.shppL....ucsIL.tp.Yp......+tsphc...hshp.ch.uuLE+htpp.....ssst.hhhpluhlhpsL+s.......h.....................................................................................................................................	0	38	107	183
+12641	PF12806	Acyl-CoA_dh_C		Acetyl-CoA dehydrogenase C-terminal like	Coggill P	pcc	Pfma-B_46 (release 24.0)	Domain	this domain would appear to be the very C-terminal region of many bacterial acetyl-CoA dehydrogenases.	26.00	26.00	26.00	26.00	24.90	25.90	hmmbuild  --amino -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.56	0.71	-4.28	470	2011	2010-02-22 18:15:35	2010-02-22 18:15:35	2	6	866	0	708	1823	1503	128.00	25	21.59	CHANGED	thhsclpshhppttt.....t....th.t.shsptLtpu.hpplppssthlhtpst.ss..........s...pts..hAuussY..LchhGhlshuahah+hAhsA.tth......................tt...................................t....ts......Fa.puKltsA+FahpplLPcssuhhstlps..Gsss.lhshst	...........................h.hhtplpphsppttt.........st..th..t.thtp.Ltpu.hpplpp...hTthlht...psh..ss............s...ppssAuussYLphhGhlshuahat+.hAtsAtppl...............ss...............................t.....ts...ts.....FYpuKlssA+FahpplLPcssuhhstlpu..ussslhshs..............	0	183	408	579
+12642	PF12807	eIF3_p135		Translation initiation factor eIF3 subunit 135	Wood V, Coggill P	pcc	Pfam-B_2213	Family	Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation [1].	21.30	21.30	21.40	21.50	21.20	20.80	hmmbuild  --amino -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.30	0.71	-4.32	65	500	2010-02-22 18:22:24	2010-02-22 18:22:24	2	76	258	0	376	485	1	166.80	22	13.01	CHANGED	tsppssPhDGpoLophLHpRGINhRYLGc.......lup......htp....................pLttlppLslpEhlsRuhKHlhpphlp.....................................sl.ss.................sthuusluHhLNCLLGst.ss............................pspsphcpph..................................................t.....spss.satplTs...............ppLhppIppplpp+acasLp...............schhs........p.lp+hpLLRslshKhGlQlhs+-YsFs	.....................................h......PhDG.toLsch...hHp+GINhRY.LGclhph.......htp....................................................................................plpt.l......pplslpEhlsRuhKHlhpshlp....................................................................................................................................................................................................sh.....................hs..ss.luc.hLNslLus..ss......................................................p................................................................................................................h..hs........................ptl.h.p..lp..p.hh.hapapl................tp.hp.........t.hppht.llRths.+hGlplh.+.ca.h....................................................................................................................................................................................................................................	0	144	232	330
+12643	PF12808	Mto2_bdg	Mto1_bdg;	Micro-tubular organiser Mto1 C-term Mto2-binding region	Wood V, Coggill P, Eberhardt R	pcc	Pfam-B_28820 (release 24.0)	Domain	The C-terminal region of the micro-tubular organiser protein 1 (mto1) is the binding domain for attachment to Mto2p.The full-length Mto1 protein is required for microtubule nucleation from non-spindle pole body MTOCs in fission yeast [1]. The interaction of Mto2p with this region of Mto1 is critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis [2].	21.40	21.40	21.50	21.40	21.00	21.30	hmmbuild  --amino -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.55	0.72	-3.86	9	126	2010-02-22 18:30:33	2010-02-22 18:30:33	2	5	97	0	91	132	0	50.50	39	5.17	CHANGED	+WlpRLcELEppLKAER.EARhhD+oGA+cRLp-hptENccLpApLp+p+.pp	........+hl.RLcELpp+L+uER.E.....tRhhDpsuAcpRlpclcsENcpL+ucLph.p.t........	0	13	35	67
+12644	PF12809	Metallothi_Euk2		Eukaryotic metallothionein	Wood V, Coggill P	pcc	Wood V	Family	This is a family of eukaryotic metallothioneins.	80.20	80.00	80.20	80.00	78.60	78.40	hmmbuild  --amino -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.27	0.72	-3.59	2	16	2012-10-05 18:33:37	2010-02-23 09:22:44	2	1	13	0	2	9	0	75.50	58	72.34	CHANGED	sl+.pDCEstCCpcus.pCtSpCh.psStGphCpsph.hGp.pspsChcphpC.........ohs..pCpK.u+pphtKp	ClRNQDCEoGCC+cAPspCESHCsEKGSEGSLCQspsFFGQYRsCPChcNLTChY.KstKW.oIsaGpCQKlu+ppLtKp...	0	2	2	2
+12645	PF12810	Gly_rich		Glycine rich protein	Bateman A	agb	Jackhmmer:Q183Y9	Family	This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.	24.50	24.50	24.60	24.80	24.20	24.40	hmmbuild  --amino -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.36	0.70	-4.79	103	677	2010-02-23 09:42:22	2010-02-23 09:42:22	2	34	107	0	572	663	155	230.70	22	43.92	CHANGED	sCTs.YplpLs.sGhY+hElaGAuGGs.t.............................hpp......ss....h.G......GtGGYssGhlplppppphYlhlGupG............p.s.....tp............h..h...GGasGGGpust..........................t...hu.uuGGG..uTcl+hh...........................ssLtsRl....lVAGGG.GG.u.ss.......st..........t.sp.............................................................................G......GsGG..Gltu....tssh....tt....sp.........ss.s...........uu.sp.puuG..u.............hp...p...........s..t.......sGshshus......ss.....sp.................u.......GGGGGaaGGhuu.............p.....t.s........uu............G.GGGSSal...hsp..su..hh................s..tsslps.......sshhapssthhpss...................tp................pp.................GsGhhpITlLs.h..t.hs..s..phh	................................................................................Y.hph..hG.AtGG...................................................t....uhGs.hh.uhh......l.t.p..t....ha.hhlGtpG.......................p...................................tsh..sG.s.s...s........................................u.uuGGG..uT.l.hh.....................psh..phl....lVA...u..GG..GG.s.s........t.............sp.................................................................................u.....GtGG..uhtutssh.......tt.................st........................susp....h.tsu..tu........................h..p...........t.t.....pGshuhuu.........ss....ss..................................uGGGuGahGGtuu.............................t..ts.....ss...........G..uGGSSal...ts...h.......................................................................................................................................................................................................................................................	0	505	515	542
+12646	PF12811	BaxI_1		Bax inhibitor 1 like 	Coggill P	pcc	manual	Family	The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.	22.90	22.30	23.10	23.10	22.80	22.20	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.90	0.70	-5.24	8	694	2012-10-01 20:22:31	2010-02-23 10:16:08	2	3	645	0	171	575	640	247.90	32	92.43	CHANGED	M...RcoSNPVFRSL.......PK.ppG.GYA........pFGou.Auuhus..QphstpsYtst.....ppssssRshTIDDVVsKTGITLuVLshsAVVSYFLVssNssLuhPhshlGulGGLslVLlATFGRKtDNPulVLsYAuhEGLFlGulSalhuNlhsuGusu..hIsQAlLGThGVFF..GMLVVYKTGAIRVTPKFTRMlluuLaGVlsLhLGNllLAhF.sGss....LpsGGsLAIhFSLlCIGlAAFSFLlDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYlEILRLLSYhpN-	.................................................................................................................................................................................................................................................ttt.ss..p..p.s....MTlssllsK.T.u.l..h..L..t.l.l..h.s.s...u...s...h.....u....a.....h......h...h.....h......s......p.............s...h....s...h.........h.......h....l.....l...G.u.....l.s.u.hl....l.u.h.lss...F..t..p...ph.sPsh..s..l....h..YAhhEGlhLGulSh.ha.p.......t.......h.su........llhpAl..Lu..Thushh.sh.Lh.lY+.sthI+VTs+FpphlhuuhhGl.hlhhLs.s.hlLshF....s...ss...................hlts.....u...G...s.....l.G.Ilh....Sll..s.lslAAhsLl.lDFDh.h-pulct......tAPcp.......h.tWhsAhGLhVTLVWLYlEILRLLShhp..p........................................	0	46	106	140
+12647	PF12812	PDZ_1		PDZ-like domain	Wood V, Coggill P	pcc	Pfam-B_17100 (release 24.0)	Domain	PDZ domains are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates. this is a family of PDZ-like domains from bacteria, plants and fungi.	28.00	28.00	28.00	28.20	27.90	27.90	hmmbuild  --amino -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.45	0.72	-4.09	34	382	2012-10-02 11:12:46	2010-02-23 10:45:31	2	15	206	0	258	391	21	76.80	30	13.96	CHANGED	sITPsRaVpVuGAoFHcLSYQ.ARpaslsl+..GVaVucuuGShph......ss...tspuallpplsspsTPsLDsFlcVh+plPDp	..............lpss+hlphsGAsh+clsaptsRph..s..h..sht...shhs.u.c.u.s.GShth.......ph...lssshlIppVsspsTssL-sFlclh+pIPDp.......	0	56	147	227
+12648	PF12813	XPG_I_2		XPG domain containing	Wood V, Coggill P	pcc	Pfam-B_10579 (release 24.0)	Domain	This family is largely of fungal proteins and is related to the XP-G protein family.	29.20	29.10	29.20	29.10	29.10	29.00	hmmbuild  --amino -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.69	0.70	-4.88	26	211	2012-10-01 19:52:02	2010-02-23 11:52:00	2	8	149	0	162	230	5	227.40	18	35.47	CHANGED	tssFhVsslhEsL+sp.p...................................aushs.llsGEADsaCAhhA.+phGs.sVLTsDSDLLlHDL.G.pGullFhsol-hss...................................................t.hplpAhphpssslsc+Lul....sl.hlAa.........El.ppcsctshspllcpu+t..spssspppspYhsFlcpY........ts...........ss.thptLDs+loElhhph....................tcptsplYLshLl-stuRpsAWt..pupphR.lAYulhshpt.......hspptssltEhhRp...upchsspplsl	...............................................................................................h.s.hhh.shhpsLpph......................................ss.hhhs...u.EADt.hA....slA..pph.s............C.......sVLo..sDSDahla...cl......psualslsslp.hcs..............................................................................................hl.psphap.sphsp.p.hsh..............Ls..hh..Ah................-h.t..s..h..tp.h.....ph.h.th..stt........t......t...tph.thhp.h......................................................................................................................................................................................................................................................................................................................................................................................	0	65	86	127
+12649	PF12814	Mcp5_PH		Meiotic cell cortex C-terminal pleckstrin homology	Wood V, Coggill P	pcc	Pfam-B_1220 (release 24.0)	Domain	The PH domain of these largely fungal proteins is necessary for the cortical localisation of the protein during meiosis, since the overall function of the protein is to anchor dynein at the cell cortex during the horsetail phase. During prophase I of fission yeast, horsetail nuclear movement occurs, and this starts when all the telomeres become bundled at the spindle pole body - SPB. Subsequent to this, the nucleus undergoes a dynamic oscillation, resulting in elongated nuclear morphology. Horsetail nuclear movement is thought to be predominantly due to the pulling of astral microtubules that link the SPB to cortical microtubule-attachment sites at the opposite end of the cell; the pulling force is believed to be provided by cytoplasmic dynein and dynactin.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.76	0.71	-4.20	26	320	2012-10-04 00:02:25	2010-02-23 11:54:51	2	30	183	0	235	344	1	121.30	30	9.25	CHANGED	sllsAIsQTMlGEahaKYsR+p..p..h..............................tpsRHcRahWlpPYppsLhWSsppPtsussptspspp.lhIpuVtsVcDsNshPpGh.......ap+SIlIhTssRslKlTAsoppRHplWhsALpaLhpp	.............................................t.hhpAIspshlG-ahaKYsR+t...t..............................ts+HcRaFW.ls..P..a..pps..LhW..Ssp.pPp.pss....t......hpsp...................p....ltIpu.Vps.V..pD...s...s......s..hP.uh................ap....c..Sll..ll.os.p....R..sl+hTssotp++psWhsuLpaLh....................................	0	67	124	195
+12650	PF12815	CTD		Spt5 C-terminal nonapeptide repeat binding Spt4	Wood V, Coggill P	pcc	Pfam-B_197031 (release 23.0)	Domain	The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe [1]. The repeat has a characteristic TPA motif.	25.40	24.80	25.60	25.10	25.00	24.40	hmmbuild  --amino -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-12.09	0.71	-3.70	33	296	2012-10-02 12:52:19	2010-02-23 14:16:34	2	28	170	1	213	294	3	130.10	32	17.37	CHANGED	uu+TPAasu..........sGu+TPAW...tsGupTssh.h................GuRTPsass....Gu+TPh..................htsGu+TPAauusss...........upTPuast......................................................ssshhuusoPush......sss.TPuu..tusTPu.....................s.uusoP	...............................................................upTPhass...........GuRTPta.....GSpTPh...s...............................GuRTPsat........GopTPh...............................tsGSRTPAauus.s...................spTPu.hstt....................................................................s.....s...ss.....................................................................ss.........................................................................................	0	76	113	178
+12653	PF12816	Vps8		Golgi CORVET complex core vacuolar protein 8	Wood V, Coggill P	pcc	Pfam-B_90 (release 24.0)	Domain	Vps8 is one of the Golgi complex components necessary for vacuolar sorting [1]. Eukaryotic cells contain a highly dynamic endo-membrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering).  Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intralumenal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes [2].	19.90	19.90	20.90	23.50	18.90	17.20	hmmbuild  --amino -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.19	0.71	-5.06	42	312	2010-02-23 17:00:45	2010-02-23 17:00:45	2	13	243	0	230	320	2	182.20	31	13.50	CHANGED	pslFL-sLEsaIlpGplpslPPtlhKsLlpaassppphpplEclIspLDssoLDlDpsspLCccasLYDAlIYlaNpslsDYloPLh-Llphltp.tp..............hsts...........ssuhKlasYLuhlLoG+tYPoGcth.spp..cshpuKpplaphLFSupshshs.ssst............cssFPYLphlLcFDspsFLshLspuF	............................................................................slFL-sLEPaIlpsplp.s.l.sP..tlh+sLlsaa.t.spt.........h...h.........pplEphIh+hDhsoLDl.sQ..llpl.....CpcapLYD..AhIYlaNcu.hsD...YloPl...cLlp..llts.hptt................t.hstt........................................s.u.KlhsYlS..hsLs.GRsYPh.Gc.h..sp.p...............h..s.psKppl....apaLhptp.shphs.t................................c..aPal+hLLcFDsppFLssLs.sF.........................................................................	0	86	132	195
+12655	PF12818	Tegument_dsDNA		dsDNA viral tegument protein	Coggill P	pcc	Pfam-B_48 (release 24.0)	Family	This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.	20.70	20.70	20.70	20.70	20.50	20.10	hmmbuild  --amino -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.51	0.70	-5.53	11	214	2010-02-24 16:15:47	2010-02-24 16:15:47	2	2	24	0	0	95	0	223.90	74	46.53	CHANGED	lppuhhHlHSslpshup.QLpshlFpsoLhPtspspuushGhY.sTssu.sushstshpcplttsspspucsLspsGVPVluGFl+sl....pptuthstsslhpsShLsosspstLshsR.thGQhlVsLGsFpPssGsDssPahYp-SshshN+lhpsLcLFtphhsssClSuhtRshG.soslcHLhuLl.tsGhpLalSpLPp-lhstLtussssp.st..lcphVpsaFLNshss.lFLllspcs......spsps.psL-hLppAuclsGCshhlLGcTsspsGl	................................................IHGAYTHVHSSVQRGIR.GLGNLLFHSTLFPGGQTQGALTGLY.ATEPA.LGPRAHSRFRRIFAKGVQ.....QAEMLQGAGVPTLGGFLKTV......RTIATTP...G.NALAVCS.....IS....TTTSKE....CIS..LRRMI.P...QQ.T.VVC.LGR..FEPTD.GPDTYPNLYRDSSDNAVRILETLKLVQRLA..KG..P..IF..SGL..NRSHDPAPVVRHLQALAP.R.TGLELFVSKLPDEV+s+LsAcPuAsssu..VcusVu-HFLNVYCSlVFsVVu-oG....ulPuDhGcTPLElLQRAARLCuCQlsVLGRToEpPGI.....	0	0	0	0
+12656	PF12819	Malectin_like		Carbohydrate-binding protein of the ER	Coggill P	pcc	Pfam-B_41 (release 24.0)	Domain	Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  --amino -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.84	0.70	-5.36	155	1073	2012-10-01 23:47:32	2010-02-24 17:09:37	2	67	112	0	617	1235	5	284.20	22	44.21	CHANGED	IDCGhsssps..a.-..s.slsasoDs.sahs..sGt...hth....t.t.t.s..h.p.htslR.FP...tsp..+.sCYsl.sh...ttt.+YLlRspFhYGNhp.........s..t.ph....ss.F-LhlGsshWssVph................hhtE.llhss.....t..splslCLlssu....ss..PFISuLElRsL..psshY.................h.ps.sts..LphhtRhsh.uss.................................lRYssDs..aDRhW........s..............ssthpphss.....s......hs..t.st.t..tsPptVhpTAhss..ssss................lphsa......sh.ssss..p............ahlhhHFuElpp...ps.........RpFslhlNst.........shps.hhhstsh..hpshhhph.tst.....hhh.sLttsssS....sl.sPllNAhElapl	............................................................................lsCG................sh.ahsDt..thht......ss.........s.pl.......................h.shR..Fs.............t....p..sY.sh.s....t....pahl.RhhF..h.......sshs............t.............s.a..l.hh.sh....s.hh...h........................hhhE.hh.ss...............s.lplsh.hsps........ss.sFlsslE..lhsh...ss.p.ha.............................ts..Lphh....hRhsh..Gspt................................lphssDs......hsRh..W.........sh...........................ssthtt.hss.............t.p........hp....ststh..hsP..t....V.hpT.......Ahsh...ssst..................hp.hsa........ph...ssss.h.p.............ahlhhaFsElpt...t.................tR.FslhlNsphh......p......sht.s....h..h.t.s...s.h.........ht..hhh.t.h...st..........h.lslt..ss.to........th..ssllNuhElhp......................................................	0	88	348	486
+12657	PF12820	BRCT_assoc		Serine-rich domain associated with BRCT	Coggill P	pcc	Pfam-B_51 (release 24.0)	Domain	This domain is found on BRCA1 proteins.	21.30	21.30	21.80	21.30	20.00	19.40	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.13	0.71	-4.48	83	1101	2010-02-25 13:43:55	2010-02-25 13:43:55	2	15	761	0	20	1126	0	159.50	55	27.54	CHANGED	ADsLstRKEhscQKs..CS-sPR.coQD.lPWITLNSSIQKVNEWFSRSD-hLTS.DsopDttsESNuElAuslEl..Ps-lDGaSuSSEKlDLhAS.-Pcsu..llscSERlpSKPVES.NIEDKIFGKTYRR.KuSLP..NLoHl..TE.sLIlGAh.AsEPQIsQEpPh....TNKLKRKRRT	...........................A-PLpGR+chpKQKssCS-SPR..DoQ-.lsWITLNSSIQKVNEWFSRSD-l.LTS.Dco+DtssE.SNsEsu.sslEl..PspsDGhSuSSEKhDLhAS.-sp.............s.A..LhpcSERspSKPVES...NIEDKIFGKTYRR.KuShP..NLs..+s..TE...sl.llGus......shEPp.lspEp.Ph....TNKLKRKR+h.................................	0	1	2	5
+12658	PF12821	DUF3815		Protein of unknown function (DUF3815)	Bateman A	agb	Jackhmmer:Q183G2	Family	This family of membrane proteins is functionally uncharacterised.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.52	0.71	-4.21	94	3677	2012-10-02 11:53:07	2010-02-25 14:38:39	2	9	2742	0	637	2738	47	132.40	26	47.57	CHANGED	lphlhualAsluFullhsl..P..+..+tlhhsulsGulGWhlYhlh.h.p...hs.hs..h.hh.ushhuulslulhuphhA+hhKsPsslFhlPu.llPLVP......GstsYpshhthl...................p............sp............httu...........hph....................................hlpslhluuAIAlGlhlsshl	...............................h.phlhuhl.u.sluFu..l..lh..N.s..sh...+t..L..hhsull.G.u..lu.a.h.h.h....hlh..h.p...........hs...hs....h....h....h.uoF..h.u.uh.llGh...l..........u....t.........h..h......u..+...h...h..+.........s........P..s....h..l..a..........hl.su..llPh.VP......Gh.huY.p.uh...hshl...............................................p............ts........................hspu...........h.sp............................................................hhpshh..lssAlu...lGlhlsph.h.....................................................................................................	0	196	382	532
+12659	PF12822	DUF3816		Protein of unknown function (DUF3816)	Bateman A, Iyer LM	agb	Jackhmmer:Q188H8	Family	This family of proteins is functionally uncharacterised but are likely to be membrane transporters. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 177 and 208 amino acids in length. A subset of this family  is associated with the TM1506 proteins. In this context, transport through the channel is predicted to be regulated by the TM1506 protein by either regulating redox potential or modification of substrates [1]	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  --amino -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.66	0.71	-4.37	172	3851	2012-10-03 02:46:00	2010-02-25 14:48:37	2	6	1995	2	522	3039	57	168.30	20	85.15	CHANGED	+pl..............shhullsAluhlLh.........hh.hs....l.........p.hshsplssl..lu.....uhhhGPhsGhhluhl...psllphhh...h.................................................s.hh.hh...................hsshlsthhhslsss....hla..tppppptth.............................................................hhuhhluslhhslssslh......shhlh...h.ha...................h...............................................shhthlhhshlshsllcsllssllshhlh	..................................tlshlulhhAlshllt...........hhs.hs.....l...........p..lshsp..lssl...lu...........uhlhG......PhhGhlluhl....psllph.....l....l.....s..sh....................................................s.......................................hhshlsthl.hu.lssu.........hl.a.p..h.h...p..p..p.s....h....................................................................................................................hhu.l.llu..s..l.hh..o.ls.h....ol...l.............shhhh...........h.las................h.....................................................................slhthl..h..s.s.ll.s.hs.llctllsullhhhl.h..............................................................	0	216	361	451
+12660	PF12823	DUF3817		Domain of unknown function (DUF3817)	Mistry J	jm14	Pfam-B_123 (release 24.0)	Domain	This domain is of unknown function.  It is sometimes found adjacent to Pfam:PF07690 and Pfam:PF03176 which are both transporter domains.	27.00	27.00	29.10	28.80	26.10	25.90	hmmbuild  --amino -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.16	0.72	-3.55	149	830	2010-02-25 16:16:58	2010-02-25 16:16:58	2	6	649	0	275	668	179	92.30	31	73.20	CHANGED	sslpt...aRllAhhEulohllLl.luM.slKY...h...........h............shs....h..slpllG........l.........HGhl.FllYllhshtlshch+Wsh.tchlh.shlAullPFuoFhhE.+hlp...+c	........s.slttaRlhAhlpGlshllLl.luM.slKY...h.....................................s..................shs.....t...sVpllG.......h.s..................HGhl.allYllss.h.luh.ch+Wsh.tph...............lh.shlAuslPFsoFhhEphhp+.p............	0	92	210	255
+12661	PF12824	MRP-L20		Mitochondrial ribosomal protein subunit L20	Wood V, Coggill P	pcc	Pfam-B_1364 (release 24.0)	Domain	This family is the essential mitochondrial ribosomal protein subunit L20 of fungi.	30.10	30.10	30.10	30.20	30.00	30.00	hmmbuild  --amino -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.02	0.71	-4.28	34	157	2012-10-04 14:01:12	2010-02-25 16:34:37	2	4	148	0	105	147	0	159.90	28	73.35	CHANGED	hhps+spuohp+s+pphp..lpPs.o...................llaNPPuSuPoshp....TPttFL...PtsDsR+phh.ttt.t.s............................spphPslhptcsp.....+p..YpLos-sIpEI++LRtpDPhpao+tpLA+cFssSshFlshls..pss...p++cthcph.Lpslcs+W.us+RthAR-..DRp+R+Eh.W	................................................................................h....p.pss.tptt.thp..h.Pt..................................hhapPssStsos.h....sPh.hFL...PtsDsRRth..........tt.................................................tphPslhpsppt.................+p....apLssp-lpEh++LRtpDPhpaohppLA++Fss...SthFVthls........psst.....p+pp..cph....hpthpppWs.p+phARc...-RphR+phh......................	0	23	53	87
+12662	PF12825	DUF3818		Domain of unknown function in PX-proteins (DUF3818)	Wood V, Coggill P	pcc	Pfam-B_972 (release 24.0)	Domain	This domain is found on proteins carrying a PX domain. Its function is unknown.	21.70	21.70	22.70	21.80	20.90	21.60	hmmbuild  --amino -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.93	0.70	-5.77	27	228	2010-02-25 17:01:20	2010-02-25 17:01:20	2	11	134	0	189	245	0	268.10	26	34.73	CHANGED	sLtclFpEl+ppsslp-LSP.hpsFsEWs+lplAuTlYphFlusD.NS.Ehasp.....s++lHpLhPYslhtpllRhoNPhulMpshlDLFL......................AQP...FG.u+SLLQphFshhLs--l+shcctlcpLcp.plts.....phhhp+lcpal..ss-.....s....hhstl+c-utp.....pshslllsILpssp......p...stlss.....splpclhpSYhsapshhpp..........................sptppstuhhasplKplhplhh+cRDKchMppLhp-.PthspLlKsllolFY-PLl+la+sAslp.ulpsFppFhsDLIphl-phppt..hhhssshpsVpthhsLls+HpssFacFlHclah+Dst.....lFpslhpWlcpllphL+psh	.......................l.plhtplttptplppLs..hpphh-ahp...l...p...lAuhlaplFlsp-.su.thhtt..........h+clHplhPYthhpphl+hsNPhshhpuhlclhL......................ups....hG..upsLhQ......phhuhhlp-...s...h..pp..hpct.lctl.tt.plts............hhhpplctas..tscp..........pptl+tc.utt.....pshsll..hslLpsp.....t..s.ls..............tthtpl.ps...a.......................................tt.ha..hpphhphhhppRD+t.hhpl...hp........c...s...h.hphh+s.hh.s..hhYpPlh.c.laptusl..slpshttFhsDhIt......h.........lcth...........p................h.....................t........s................ps.........VpshhsLht+HppthapFlHplhhpsst.....latthhtWhpthlthh+p..s......................................	1	59	117	167
+12663	PF12826	HHH_2		Helix-hairpin-helix motif	Bateman A	agb	Jackhmmer:DISA_CLOD6	Motif	The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.82	0.72	-4.09	72	5697	2012-10-03 02:11:09	2010-02-25 17:13:14	2	57	4306	6	1394	5279	3189	61.40	32	9.52	CHANGED	clh..hh...LGIRaVGppsA+hLApcFt.ol-sLtpAohE-Lhplc-IGshlApSlhpFFps.psppll	........................+hlhu..LG.I+pVGtpsActL.A.p.....c.Fs..o.......l.......-....s............l..........t....p..........A............o..........h............E..............-..........L...t.....p.....l...s...slGthlA.pslhsaFtptt..t....................	0	461	920	1195
+12664	PF12827	Peroxin-22		Peroxisomal biogenesis protein family	Wood V, Coggill P	pcc	Pfam-B_15020 (release 24.0)	Family	Peroxin-22 is a integral peroxisomal membrane protein family. The N-terminus is in the matrix and the C-terminus is in the cytosol. The N-terminus carries a 25-amino acid peroxisome membrane-targeting signal. It interacts with the ubiquitin-conjugating peripheral peroxisomal membrane enzyme Pex4p anchoring it at the peroxisomal membrane. Both Pex proteins are involved at the same stage of peroxisome biogenesis.	21.70	21.70	21.70	63.60	21.40	20.80	hmmbuild  --amino -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.56	0.71	-4.39	17	42	2010-02-25 17:17:23	2010-02-25 17:17:23	2	1	41	3	28	39	0	120.70	32	66.90	CHANGED	ptsptp.pp+hsscSlslslSpolhssph..ls.hhhsscshlhllsPsls.t...............phphppp.tthtssaKllpCsshp...................GhapllKpL+schLL...................................lssD-ls.s.......lspD...............ls+Flppllsl	........p..tppspcp+hspKShsIl.lScSl.u....Plph..hss--lVhllPPsho.ssh..............t.thtps.pppts.paKlIpCcohp...................GhauslKpLptpphl...................................lsocDhssu.......lPcD...............ls+Fl+plls.......	0	5	15	25
+12665	PF12828	PXB		PX-associated	Wood V, Coggill P	pcc	Pfam-B_972 (release24,0)	Domain	This domain is associated with the PX domain.	20.90	20.90	21.00	21.50	20.70	20.40	hmmbuild  --amino -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.67	0.71	-4.56	28	179	2010-02-25 17:31:20	2010-02-25 17:31:20	2	11	129	0	143	195	1	138.40	37	14.82	CHANGED	M......................tLossppHaLK+.LlchpLtpElpthspP.....ssLppaGhPFps.t.......s.ppppsp...............................hPlLpahhppFlh..oFPhl..........ptstppcFWps+lQsFlEphsptslSsS.D+p....ploKR+plspKhpshlhLhhsos	..................................s......p.LTspQpHYLK+pLlptQlp.tElppLss.P.......sALppaGhPFpss.......sph..ss.pt....t.p...........................................................................................................................lP.l.L.+alFhcaVh..sFPhL...................ppstpc-.....FWQsKlQs........FlEsFssppl...SsSt...DRt............c..oKR+pLutKhp+lltLhhsS.u...........................................	0	42	84	126
+12666	PF12829	Mhr1		Transcriptional regulation of mitochondrial recombination	Wood V, Coggill P	pcc	Pfam-B_7788 (release 24.0)	Family	This family is involved in the transcriptional regulation of recombination in the mitochondria,	20.50	20.50	20.50	41.20	20.00	18.70	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.78	0.72	-4.16	24	112	2010-02-25 17:49:44	2010-02-25 17:49:44	2	1	111	0	86	104	0	90.70	37	29.53	CHANGED	ausplalF+NlposQVlYSpsPshspppl.pQh.hsshcs+.......sshR+DhW+sMsVlsFs...shphulpsYpsLtchRhhR.pls.tcps.ph++	........aG.plalacNlcosQVlYS.s.tlcpppl.pQhsh....upcsh......PssLR+DhWpPhsslpFs....ssphG....lpsYptLREh+hhR.pls.sc-h.ph...................	0	13	41	71
+12667	PF12830	Nipped-B_C		Sister chromatid cohesion C-terminus	Wood V, Coggill P	pcc	Pfam-B_443 (release 24.0)	Domain	This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.	26.40	21.50	27.30	21.60	25.70	21.00	hmmbuild  --amino -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.88	0.71	-4.65	57	312	2010-02-26 10:34:20	2010-02-26 10:34:20	2	9	257	0	213	314	3	182.20	28	10.29	CHANGED	hsuulsQ+ahpplLc.hshsppsplphhAlcllphll+pGLlpPhpslPslIALpss.spshlpphAhphhpplppKapuhlpsp...hspGlphuapapppl.tp....h...............................ssshhsplapllp.ss+..psRpcFlpslh+hhp.p..............................t.lphhhalspslAhlsaps.-Eslhllppl.....ptl.l	..........................huoulhQhaLcplLc.hhhpppsplphhAlp...........llthhlp.QGLlHPhp....slPhLIA.....LtTs.spsthpphA.p.hpplccKatuhlct.c...hht.G.lphuaphQpsl.ss.pssh.t..................................................................ssuhhutLY..sl.l+..ss+..ppRctF...lpslhpha-tp...................................s.splphhha.lu-NLAhhsYps.-EsLhllppl-hh.................................................	0	73	120	180
+12668	PF12831	FAD_oxidored		FAD dependent oxidoreductase	Mistry J	jm14	PfamB_47 (release 24.0)	Family	This family of proteins contains FAD dependent oxidoreductases and related proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.48	0.70	-5.40	240	2577	2012-10-10 17:06:42	2010-02-26 14:20:32	2	89	1337	8	853	18895	7151	241.30	22	42.20	CHANGED	DVlVhGGGsuGlsAAlsAARtGt....pVlLlE..ppshLGGhsouuhs.sshhu...........h..t........................hhsG.lhpEhhpcl..........tt...t.......................t..........................a-Pcshptlhcphl......tc..s.........slplhhpstl............sslt....t.....p...s.......................c..lpulth..................spt.u....thplpAchalDuTs-GDLsshAGssaph.GcEsps...hsps.....ssh........................hh.......phssh..............................................sptht........h.....hph......thssps.tpth..sh..................stsas.tphph..................thhpt.............................hsup..........hsh...................h-hh.........shscuph..psR..cplh......p.hhtslhpal.....t..................Ghtp....splt..................thu.thhlREoRRlhGpaslTppDl.........hs............t.........ppas......D..uluh.usas.lDhH....ss.pth....................tsh..thtsss..........Ys.I........PaRuLlP.ps....hcNLlluG+slSuoHhAhuohRl.ssshshGpAAGsAAA...l...u....lcpst..........s..s.ppl.......s.....hppLpppL	.........................................................................................................................DllVlG.uGsuG..h.sAA.l....s..A..A..c..t....G..t..........cV..l.L.l..E..........c..........p..........s...........h..........l......G.......G......t.....h...s....t....t....h..h............................................................................................................h...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	296	586	747
+12669	PF12832	MFS_1_like		MFS_1 like family	Wood V, Coggill P	pcc	Pfam-B_20770 (release 24.0)	Domain	In fungal members this domain is found at the C-terminus of putative transporter proteins.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.31	0.72	-4.19	39	546	2012-10-03 03:33:39	2010-02-26 14:36:54	2	10	360	0	338	2373	283	74.60	24	14.28	CHANGED	.hhhLushYFhaFuslGslhPYhulahc.p.hGassppIGhlhsllhhoclluPslauhluD+huptthllhhushhsh	......................................h.lpsh.Y.Fh.a.a.u...sh....Gs..h..h....P..a..h....slah.....c.....p...hG.....hs.ss.p......l.....Ghlh....u.l.h..........h.....h.ch....lu....ss.l.aGhluD+.h.t.pt.thllhhuhhh..s...........................	1	135	186	282
+12670	PF12833	HTH_18		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q17ZT7	Domain	\N	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  --amino -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.61	0.72	-3.88	512	57814	2012-10-04 14:01:12	2010-02-26 15:54:55	2	267	4045	19	12899	44029	2241	79.60	26	23.35	CHANGED	lApthshSt+pLp+hFp.phh.G.hostpalpphRlppApphLh..p.............s...s...h..s.l.pc..lAhphGFsshupFschF+chhGhoPsph...+pp	..............................................lApphshStppL.p...+hF+.p.h......G..ho...htpalp.phRlpp....Ap.ph..L...p...................................s....s.......h...s..l..sc..lAhps..G.a.s.s...s.tFs....+tF+.+h..h..G.hoPspaRp..........................	0	4087	7939	10539
+12671	PF12834	Phage_int_SAM_2	Integrase_l_N;	Phage integrase, N-terminal	Coggill P	pcc	Pfam-B_50 (release 24.0)	Domain	This is a family of DNA-binding prophage integrases. It is found largely in Proteobacteria.	21.90	21.90	21.90	22.00	21.80	21.70	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.84	0.72	-3.60	22	357	2012-10-02 14:21:04	2010-02-26 16:41:55	2	6	239	0	81	331	30	87.30	33	31.33	CHANGED	MscLsh-hKpLA.+.p.s.u.GSapThpsRh+hhpphuccL.ttLshplpssppLKs+HlEuhlpphhupsIottTLpNcMutlRhhhppAGRspls	.................................t.Lttphh.tLA.+..p.s.u..GSa.KT..hpDRh+lhpRhsccL...ht.h.sl..p..lpps..pplKs+HIcsYlpphh.s.p.G......luh+TlpN-MuslRslhptsG+ppl..........	0	14	32	61
+12672	PF12835	Integrase_1		Integrase	Coggill P	pcc	Pfam-B_50 (release 24.0)	Domain	This is a family of DNA-binding prophage integrases found in Proteobacteria.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  --amino -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.13	0.71	-4.53	21	412	2012-10-02 14:09:14	2010-02-26 16:45:15	2	7	286	0	101	918	314	159.80	31	55.67	CHANGED	GluuASRs.GTKhAIss.-capplLspsctpD.pGlAsslpLuRhhGLRocEAVQsspSL+TWppuLtp..G-s+lpVVFG...TKGGRPRcTpll..-p-plhpslppAlthupppsG+LIc..+PsL....+sAhcpa+shspc.uGLsG....pauPHSLRYAaAp-AhpaahppG.hSp+EAhAhsSMDLGHGDGRGcYltpVYs	.......................................................................................................hpthhpt..sp....t......p.....c......t......l...A......s....u.....l..p....Lu.+hh...GLRspEu.......lph.......s.........t.......s.h.......t....................................h....p...........spp...p.l...t...l.h.h.G...........TKG..G.Rs....Rps.......lh..........pp..th...h.p.s........l......p...p.....A.......h...........t..........h....s....t........p...p....s.........s.p...L.Is.......c.s.l...................+ps..h..p......h.....a.c..p.t.h.pc.....h....G....l.s.t............t.h..s...s...HuLRauaAQ.c.th....phh..................tt......s..h......s..........................................ht.thtH.................................................................................................	0	14	48	78
+12673	PF12836	HHH_3		Helix-hairpin-helix motif	Bateman A	agb	Jackhmmer:Q182I3	Domain	The HhH domain is a short DNA-binding domain [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.84	0.72	-4.03	335	8248	2012-10-03 02:11:09	2010-02-28 11:38:54	2	52	4067	5	1906	6460	471	64.20	37	14.92	CHANGED	VNtVGV.....-lNTASssLLp.p.l.u.Gl..s.sslAcsIVpaRcp.p..G.sFpsRcpLh.cV.tlGsKsaEQsAGFLR	..........................tstV...sl.NTA.....Ssp......Lp..p.l...s..G..l..u..tphApsIls.YR-c..p..G.sFps..h..c-Lp...cV..stlG.sK.shEphtshlp...................	0	618	1220	1609
+12674	PF12837	Fer4_6		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q180F8	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	25.00	24.00	25.00	24.00	24.90	23.90	hmmbuild  --amino -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.38	0.73	-7.55	0.73	-3.87	236	737	2012-10-03 08:56:43	2010-02-28 11:44:55	2	86	681	0	169	11950	1256	25.10	45	8.00	CHANGED	hsphc.tspC.h.......p...C..tp..C..hts..CP.....t....t.....sl	........hthD.cpKC.s.......p...C.....h-.....ChcV..CP....E.....................	0	70	132	154
+12675	PF12838	Fer4_7		4Fe-4S dicluster domain	Bateman A	agb	Jackhmmer:Q182B4	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.21	0.72	-3.58	464	18155	2012-10-03 08:56:43	2010-03-01 13:25:32	2	690	4323	11	4999	30460	7729	57.40	30	15.10	CHANGED	pC.......h.....s...C......s.....tC..h..ts..C.................................................P.......hp..s.l.p...........h...p................p...............t......................................t..................t...h....................................t...h...p....s...p...p..........C......h.............t................C.........................s.........t...........Chs.........s..CP..p..ss	............................................................pC.l....s...C.....s.....tC..s..ps..C.........................................................................................................................................P............ts...s.....l.p...........................h.p...........................t....................t.................................................................tt....................t...h........................................................p...l....s...........p....p...............C......h.........................t........................C......................................................................G...........t.............Chp............sCPsth..........................................................	0	1801	3427	4346
+12677	PF12840	HTH_20		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q182F8	Domain	This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.71	0.72	-4.17	108	9773	2012-10-04 14:01:12	2010-03-01 16:12:49	2	62	2904	43	3329	15478	1487	61.20	27	39.10	CHANGED	sphh....ps.....Lus.ssRhpllptL.................ttpshossplucth.....s......hstss.lphHL.ctLpc.uGL.lpspcptc	.........................................hhpA.......Luc.PsRh.p.llph..L.........................tpts.hs..s.s.....cl..spth......s...............lspss.lSpHL.phLpc.uGL.lpsc+pG...................	0	1109	2238	2834
+12678	PF12841	YvrJ		YvrJ protein family	Bateman A	agb	Jackhmmer:Q189G4	Family	This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterised.	27.00	27.00	28.10	27.80	24.50	25.70	hmmbuild  --amino -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.72	0.72	-4.66	46	323	2010-03-01 17:10:41	2010-03-01 17:10:41	2	2	270	0	80	239	0	37.80	44	70.26	CHANGED	phIuNlGFPIsVulYLLlRlEpKl-pLspuIpcLsptl	.........hIuNlGFPIsVolYLLhRlEsKL-sLhpuIpcLspt........	0	33	65	71
+12679	PF12842	DUF3819		Domain of unknown function (DUF3819)	Mistry J	jm14	Pfam-B_986 (release 24.0)	Domain	This is an uncharacterised domain that is found on the CCR4-Not complex component Not1.  Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [1].	21.50	21.50	25.10	24.60	21.10	19.20	hmmbuild  --amino -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.89	0.71	-4.51	61	378	2010-03-02 15:41:44	2010-03-02 15:41:44	2	10	282	0	261	393	2	143.20	37	6.88	CHANGED	psp.L+pll.hAls+A......l+EllsPVV-RSVsIAshTTcpllpKDFAhEsDEs+l+pAAphMlpsLAuSLAhlTC+EP...L+ts....lpspl.+sl......lp..tssts............h........-phlphlssDNl-LusslIE+sAhE+Alp-I..-ctltsththR.+ppRp	.......................p.L+phlp.Al-RA......lpE..ll.p.PVV-RSlpIAshTTcpllpKDFA......h-sDEs+hRpAAppMs+sLuuuhAhlTC+EP...Lphu....lsspl.+sh....ht.tthtts...........phh.......-pththlssDNl-LuCshIcKsAhEKAh.-l..-ctltsphphR+ptR......................................	0	98	150	222
+12680	PF12843	DUF3820		Protein of unknown function (DUF3820)	Mistry J	jm14	Pfam-B_72 (release 24.0)	Family	This a bacterial family that is functionally uncharacterised.	21.10	21.10	21.20	21.40	21.00	21.00	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.25	0.72	-4.36	77	1116	2010-03-03 15:03:50	2010-03-03 15:03:50	2	5	1053	0	236	562	60	64.00	55	65.46	CHANGED	hspctLlcLsptpMPFGKYpG+hLhDLPEtYLlWFtpcG.FPpGcLGphLtlhhElKlNGLEsLlcPL	............M-pEpLlclAssh.MPFGKY.......KGRhLlDLPE-YLLWFARK..s.FPtGcLGcL.hplsL.IKhpGLppLlpPL..........................	0	53	126	190
+12683	PF12844	HTH_19		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q180H4	Domain	Members of this family contains a DNA-binding helix-turn-helix domain.	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  --amino -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.93	0.72	-3.92	149	14559	2012-10-04 14:01:12	2010-03-03 16:22:39	2	171	3576	20	2358	33000	4379	62.70	22	31.97	CHANGED	Gcpl+chRppp..sl.o...hpplup.......phth.....p.....pstlsphEps....pp.phs.....sptl.......hplsphhsls.hp....phhpthpp	..............................ppl+plR.p.p.p.......sl.o.......ppclAp...............pl.sh............s................pstlS.p..hEpG..............pp..pss............hppl....................hpls.p.hh.s.ls.hs.......hh.....p...........................................................................	0	826	1594	1964
+12684	PF12845	TBD		TBD domain	Bateman A, Masci AM	agb	[1]	Family	The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation [1]. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side [1].	21.40	21.40	21.70	22.40	20.70	21.20	hmmbuild  --amino -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.66	0.72	-4.41	10	157	2010-03-03 16:48:16	2010-03-03 16:48:16	2	2	39	2	71	128	0	55.70	39	12.77	CHANGED	.Ltc-RsNlppAahELKEEhuRlphLupsQs-hLpKLshssssspp...QsssPIpCs-+	..........lhccpsNlppsahELKEEhp+lphLopsQs-hLpKLphssststt......................p.t.ssPlpCp-c.....................	0	3	6	21
+12685	PF12846	AAA_10		AAA-like domain	Bateman A	agb	Jackhmmer:Q180M9	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null --hand HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.84	0.70	-4.98	149	6551	2012-10-05 12:31:09	2010-03-04 08:58:08	2	39	2755	0	1413	9633	1186	297.10	16	39.53	CHANGED	ssshhlhGtsGuGKSshhp.thh..hthhttG............................splhll......Dht.scats.....hsph.......................hsuphlths...........hsss.........htlN.....Ph.....pht.........................................................hppptpthhshLtthhpths.stpt.................pshlsps..lptha...................ptths...............................................................................................................................................sls-lhch..lpp...t..........................................ptphpph.tp.........tlpthh..........sthutlFs....t.oshph..........ssplls..hclsslpts.............tphhshhhhhhhshhh..pphht.............................t...........ptppphlh...........lDEs.athhss.......s....thhphlpphhRps.R+hssshhhsoQsh.sDhhs...t.............pslhstsshthhhptss..pphtt......ltphh...sls.s	...............................................................................................................................................................................................................................................phhlhGsoGu.G.K..o.h.....hhp..hlh.......tt..h..h.h.h..s......................................................................sph.hhh.......D.....t.....sp.h.tt.................hsph........................................................hsuphh.p..h.s...............................ssp...................hthN.............Ph..........................th.................................................................................................tpphph....h..h.....s..h..l...t...h..h.h.t...htstthpt...........................tshl....p..ps.......lpth.h...........................p............................................................................................................................................................................slpp..lh..ph.....lp..pt..................................................................p.thtph..tt........................................................tl.p.hh..................st.ht..h..las................................ttss.h.ph...................psph..hs.......h..-..l...s...p..ltpp..........................................thhs.h.s...h...h..h...l..h.ph.hh.....pphht.................................................................psp.thlh...........lDEs.ath.lps....................t.........htp.h...lt.ph...h..+ps.R....K.hssth.hhsTQ...s...h...sD.lh.tt..................pslhpss...s.hh.lh.h.pp.sp..tp.t.....h.t.h......t..........................................................................................................................................................................................	0	450	933	1222
+12686	PF12847	Methyltransf_18		Methyltransferase domain	Bateman A	agb	Jackhmmer:Q18BX6	Domain	Protein in this family function as methyltransferases.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.66	0.71	-3.49	195	8520	2012-10-10 17:06:42	2010-03-04 15:04:54	2	133	3477	116	2843	74852	20479	109.50	19	36.69	CHANGED	sst..pl.lDlGsGsG..phs...lthsp..........stp..lhul.........Dh......stphlphsc..........................pps.........................................tht....splp.....hhp....................uch........hsthst....................................hDh..............lhhss...............hhph......................lp..phh....ptLp.................................s.uGh........lllssh	................................................tpl..lDlG.s.G...s...G......p..h.s......l..th..sc.................................t.u.tc.......lhu..l.....................................Dh.........................u..s...t...h...l...p..h...s.c...........................................................................................................................pph........................................................................................................t......hths.......sp.lp................h.lp...........................................................u.-h..........t.h.s.h.h.tp..........................................................................................hD.h............................l..hh.st.....................................................hhsh....................h...........................lp.....t.hh...............ptLp................................................s...u.Gh...llh...hh..........................................................................................................................................................................................................................	0	981	1879	2441
+12687	PF12848	ABC_tran_2		ABC transporter	Mistry J	jm14	Pfam-B_38684	Domain	This domain is related to Pfam:PF00005.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.97	0.72	-4.14	246	15857	2012-10-05 12:31:09	2010-03-04 15:58:16	2	25	4624	0	3551	11380	1770	86.00	24	14.83	CHANGED	l-l-puclp.tYpG.NYspahpp+ppchptptptacpQQcclp+hppaIcRh+.s...pu........s+up....pAp.SRhKtL-+h....-p...lcts.....p.c....tt..p..hpF	......................h-l-pGcl.p.Y.....p.....G...NYspahcp+ppph...pppt.......p.p....pcppcplpc........p.sa.......lc..+ht.t.........................................u+sp........pu..p...uR....h+tl-....+h........cp....hp..................................................................................	0	1158	2264	2991
+12688	PF12849	PBP_like_2		PBP superfamily domain	Bateman A	agb	Jackhmmer:Q180B2	Family	This domain belongs to the periplasmic binding protein superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.99	0.70	-4.94	148	7526	2012-10-03 15:33:52	2010-03-05 19:02:32	2	29	4026	39	1757	5461	2312	251.70	21	78.69	CHANGED	sssssstsh................................................lhsssooshtshhh....p.hhts..............Fppp.ssh..............................p...........lp................h...tusGoupulpthppG....................................sDlshss..t....thscpch..ts.......................hshpt..........hslshssllllss.ts........................ssst.t.....hsspsltpIht.t............................................................................sstslthhh..RucsSG.....h.sphtpt.............................................t.ht...................ttsh...................................................stsht.s................ps.sGhhsslshssth....t.........shshss.....tshhhsh................ts.hph..............................t.....hhs.........spt.....GsaPlhpsh...hhlhhssthh..........tstsps.......Fhsahh.Ssc	................................................................................................................tst.........................t....................lpss.G.o.....osh.t.s..lhp..t..hspt.......................................atp.p...s.s.s................................................p.................ls................................h......pusG...S.us.Glp.p.h.h.sGs...................................................................sDhusus.....t.......................shpp....p..ch.....................................................thhp..h...l.........uhs.........u.....lslslN..hs.................................sslp..t.......Lo.t.pp.lt....p..I....a...t..Gc.....................l........................................ppWpp.........................................h.thss.ppIt.llp....R.ss.s...S.G..TpthF.pphlhp.t...........................................................................................................................................t.ht..........................................t...............ssshtth.........l............pp..suulua.lphu..h...........................................h......................t............................................tpthph.....................................................hts.....................h.tpsht..sssa.P..l..hp.h...ahhsp.p.p...................sttspp.....Flcahh.s..t......................................................................................................................................................................................................................	0	550	1144	1508
+12689	PF12850	Metallophos_2		Calcineurin-like phosphoesterase superfamily domain	Bateman A	agb	Jackhmmer:Q180F1	Domain	Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.18	0.71	-4.39	139	12839	2012-10-02 19:15:56	2010-03-08 14:03:49	2	60	4473	32	3683	17996	3872	206.20	16	75.47	CHANGED	M+lullSDoHs..................h.c............h...p....................pll.c..th.....p..p....s-hllHsGD...........................h.....s.............s..............p..l....hp.h.........pp.h...s........lhsVpGNs.............................................D........................tt......h....s.pph................................................................hhpl.s......................sh...................ph.hhsHG.........pt......ht......................................................................h..........ht....p..t.......lh....ttsp.pt.sscll.hhGHoHtsth........................p..p......hs..s...hlhlNPGSsshs+.............ht.........t...ohsllclpss	.......................................................................................................................+lhhlSDl...Hh...............................................s.h..p......................t.......h...p................................................p.ll...p..th...............p....p...............sD..h.l.lhs.GD.............................................................l....hs..............................t.........................................................................pph...........hc.tl.................pph..........s.............lh.h.l....t..G..N..c.................................................................................................................D.............................................t..........h...t.......h.....................................................................................................................................................h.......h..p.h.t..........................................st.........................................p.l...h..l..s.H...u..............p........h.s.........................................................................................................................................................................................................ht........................h.s.....p....t....................h.......t.hht....p......t.....s....s....c.....h..h.....l......h..GHs..H....t....s..th.......................................................................h............t.t............h..h...h........s....G...s..................................................t.......................................................................................................................................................................................................................................	0	1293	2430	3172
+12690	PF12851	Tet_JBP	TET_DSBH;	Oxygenase domain of the 2OGFeDO superfamily 	Bateman A, Zenonos ZA, Iyer LM, Aravind L	pcc	Manual	Domain	A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in  various eukaryotes, bacteria and bacteriophages [1]. Members of this  family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids [2], and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine  (hmC) [3], or further oxidation to 5-formylcytosine (5fC) and  5-carboxylcytosine (5caC) [4]. Metazoan TET proteins contain a  cysteine-rich region inserted into the core of the DSBH fold.  Vertebrate TET proteins are oncogenes that are mutated in various  myeloid cancers [5]. Fungal and algal versions of this family are  linked to a predicted transposase and show lineage-specific  expansions [1].	26.00	26.00	26.00	26.00	25.90	25.30	hmmbuild  --amino -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.99	0.71	-4.97	25	327	2012-10-10 13:59:34	2010-03-09 14:18:29	2	10	97	0	200	301	87	374.70	27	38.59	CHANGED	uhshhhsshhpsp............h.s.hht.t.p.......htphlpphsshlsslhctlsPphapttsphhsshh................hh.hhupsaoshols...............psptst.H+Dptsh.tshslhsshtts.........hcGGtltlsp........................................................................................................................................................................................................................................................................................................................................................................................................................................................huhslsspsGslllhsuphhhHussslps..................................................................stRholVaah+c	...........................................................................................................................................................................................................................................................................................hYashpt.sp.......p..sR+hch.hpp.tt...................................lcpphpplushluslYcpluPptaps.Q.h.phpphs..c..scl..............sh.p.GpPFSGlTss...............hcFss+sH+Dh+shts.G.hol.lsTLscpp..............p--phal..LPh..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hGluls.spGolll.su+h.hHusTs.lc.p............................................................s...p..pspRlolVaY.+c........................................................................................................................................................................................................................................................................................................................................................................................................................................	0	64	106	140
+12691	PF12852	Cupin_6		Cupin	Mistry J	jm14	Pfam-B_918 (release 24.0)	Domain	This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily.  Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  --amino -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.12	0.71	-4.68	212	1675	2012-10-10 13:59:34	2010-03-10 15:02:53	2	5	1105	0	494	1685	112	171.80	25	57.25	CHANGED	DsLSc.lLstl+hpushhhpsphsusWul....ph....s...ss...............hphahlhcGpshlp..ss....t.....s....lpLss.GDllllPps...p....sahl....s...ssss..................................................................ts.....................s.s...............................stllsGphphcssts....p.LlssLPsllhl...t...............t..tshlsshlphlttEstpspsGpphllsRLh-lLhlpsLRtalp	.........................................................................................................DsLoc.LLphhp...pusl..tps..h.su....sWtl......th......sst.................t..s........hpaH.h.......lhpGs.shLp..hss..................s......p.....hpLpsG-ll.llPps...s..sHpL.....s...ssss..................................................................................................p..............................................................sspllCGphphp.ps.st.....t.llsuLPchlhl........................ss.tshLpth.lthLtpE........upp.....s.t.sGsssll.spLssslhshslRtal.....................................................................................................	0	123	263	390
+12692	PF12853	NADH_u_ox_C		C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit	Coggill P	pcc	manual	Domain	This family is the C-terminal domain of NADH-ubiquinone oxidoreductase 21 kDa subunits from fungi.	25.00	25.00	49.60	48.50	20.50	19.90	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.13	0.72	-4.28	10	102	2010-03-10 16:33:19	2010-03-10 16:33:19	2	2	99	0	80	97	0	77.00	57	40.60	CHANGED	hhEhhcKlpcGcs.Y..GpSpLsshhQslAsRNSpYStLhlaVlPWFNhsNHs.HGVDhsKYYpptEtEhE................Acpst+tt.p	............M+EMVcKlKcGcPLY..GpSpLosahQGVAARNSRYStLFhpllPWFNhVNHsQHGVDTAKYYpQAEcELE...........................sEp.........	0	20	44	68
+12693	PF12854	PPR_1		PPR repeat	Wood V, Coggill P	pcc	Pfam-B_105542 (release 24.0)	Repeat	This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. The exact function is not known.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.49	0.72	-4.47	433	3378	2012-10-11 20:01:03	2010-03-11 14:22:50	2	1621	145	0	2261	22733	138	33.10	30	7.47	CHANGED	pGhpPsslTYssLIsGhC+sGclccAhclhccMp	..........................shtPssloY.....ssL.ls.u.h..C..+...s...G....c.lccA.hc.lhcpM...................	0	277	1399	1896
+12694	PF12855	Ecl1		Life-span regulatory factor	Wood V, Coggill P	pcc	Pfam-B_42039 (release 24.0)	Family	This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation.	26.40	26.40	26.50	26.40	26.10	26.30	hmmbuild  --amino -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.91	0.72	-4.66	23	165	2010-03-11 15:50:29	2010-03-11 15:50:29	2	2	112	0	132	156	0	43.20	35	21.05	CHANGED	Mu....AFssYChsC-+lh........................sssplYCS-pC+ppDpppshsttp	..............F.paChsC-+Qh.....................................ssstlYCSEsCRhtD.pps......t............	0	28	66	113
+12695	PF12856	Apc9		Anaphase-promoting complex subunit 9	Coggill P	pcc	manual	Family	Apc9 is one of the subunits of the anaphase-promoting complex, or cyclosome [1], which is essential for regulating entry into anaphase and exit from mitosis. The APC is a ubiquitin-protein ligase complex. All APC subunits are members of the cullin family proteins, which bind to a ring-finger subunit via a conserved cullin domain [2]. The APC is made up of four parts, the third of which is a tetratricopeptide repeat arm (TPR) that contains Apc9 [3].	25.00	25.00	28.70	26.80	24.30	24.30	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.73	0.72	-3.92	15	42	2010-03-12 10:19:30	2010-03-12 10:19:30	2	2	40	0	25	35	0	117.30	28	33.36	CHANGED	ssslcs+lhslppscKpt..............................h.tpstp.spYDYulF.scpss.............l+ESpIcuapsuE+hspsllFcps........s.psD.....s..............pssc.ctsp..........tptshl...slPGYTp	...........................................................h....hsh.hslppsph.t..............................slpc...tp.tppYDYSsF.sccss.............l+ES+Icua.pAE+ss+sLlFc+st..................................S.csDh................s..........ppssc.-psp............tssshll..SlPGhsp..................................	0	4	14	24
+12696	PF12857	TOBE_3		TOBE-like domain	Mistry J	jm14	Pfam-B_1384 (release 24.0)	Domain	The TOBE domain [1] (Transport-associated OB) always occurs  as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately  after the ATPase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.57	0.72	-4.11	101	1134	2012-10-03 20:18:03	2010-03-12 10:22:48	2	2	1112	0	221	704	35	57.20	31	16.08	CHANGED	sssp...sslsu.plpplp.shGshs+l..El...phh....ssp.........hlElclspcp......t.thht.GpplhlpP+	...........ps..hsuslPs.pVlcssPhGthspl...l......psh.....hhs-..........lpl.hst-c........s.pt.G-plals................	0	46	110	166
+12698	PF12859	Apc1		Anaphase-promoting complex subunit 1	Coggill P	pcc	manual	Family	Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex [3].	25.00	25.00	27.00	26.70	20.50	20.20	hmmbuild  --amino -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.48	0.72	-3.81	57	240	2010-03-12 11:41:32	2010-03-12 11:41:32	2	3	221	0	182	249	0	101.60	27	6.01	CHANGED	csLsVlh..psphplahh...s........GcsaslsLPFp.Vsssashsp..GLlLpRchs...................ssphtttt.............................................................................sshs+l.aoL...scPLsEhs.Vshps	................................slsllh..psphplahh...s.........GcsallsLPFp.Vsslass.th..GLLlpRpts........................................spphs.sss............................................................................................................p..........pshPph.aoL...hcPLsEhs.llhp.......................................................................................................................................	0	57	95	148
+12699	PF12860	PAS_7		PAS fold	Mistry J	jm14	Pfam-B_21375 (release 24.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.19	0.71	-4.08	164	2444	2012-10-04 01:10:46	2010-03-12 13:50:07	2	265	808	0	913	2460	395	113.00	23	15.73	CHANGED	LcphsQGlslaDs-h+LlsaNp+atclaslPsphl.psGts.hpcllca...spcGphu....sc......h-th....lppcl....p.thpp...tpsphhE+pp.ssGpllclpusPh....Ps.GGaVsoaoDITp..p+cu-p	.....................l-plspGlslaD.sctRLlhhNppa.t.cl.a..s.l..s..s.shl.........p.s.G..hs...hp.p.l.lc.ht....tppu.hhs.........tp........................hpph..........h.pph.h................t..t.hpp.....sps...p..p..h..p...h.p.h..sD.G..+............h..l..c....l..psp..s.h............s...s.....G......G......h....V.....h....s.ap.DlTphpptc............................................	0	225	493	644
+12700	PF12861	zf-Apc11		Anaphase-promoting complex subunit 11 RING-H2 finger	Coggill P	pcc	manual	Family	Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome [1]. The APC subunits are cullin family proteins with ubiquitin ligase activity [2]. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability [3].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.35	0.72	-4.15	5	247	2012-10-03 15:03:13	2010-03-12 14:30:41	2	9	213	0	172	3252	290	81.50	49	56.19	CHANGED	MKVKIpEW+uVATWpWDlPs.................DDVCGICRVuFDGTCPsCKaPGDsCPLVlGp.CsHsFHhHCIh+WLcspoSKGLCPMCRQoFphp-	.........................................................MKVpIp.p...Wpu.....VAsW.pW.t..hsp........................................D-sCG..IC..R..hs.....F.....-.....G..s......C.....P......s..C..............K........h........P........G........D.......D.............C..........P....L......l..h.....G............p........C............s..Hs......FHhHCIh+W...l.p....p...p......p.....s....p....t........CPMCR.ppaph...........................	0	56	98	141
+12701	PF12862	Apc5		Anaphase-promoting complex subunit 5	Coggill P	pcc	JCSG 	Domain	Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multi-subunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1.  Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [1,2]. The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC [3]. This region of the Apc5 member proteins carries a TPR-like motif.	21.00	3.90	21.00	4.60	20.90	-999999.99	hmmbuild  --amino -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.05	0.72	-4.15	26	461	2012-10-11 20:01:03	2010-03-12 16:08:58	2	64	292	0	278	1604	191	89.20	21	16.11	CHANGED	aalpYLpulpsp-Y.sAl-sLHpYF...DY..hhppsscs............................................tYpaA...LLsLAhLHspF...GctccAlpAlpEAlplARENpDpssLsahLsWlhphhcpp	.........................................................................................................................................................................h..t.ph.tuhp.Lhphh.....Dh.......t.tpt.........................................................................................hp.h.A......hl.s..L.A..t.l.ps.ph...Gph..ppA......hts....lpEAl...pl....Ap..c....sp....D.......s.Lthhh.hh.......t..............................................................................................	0	95	155	224
+12702	PF12863	DUF3821		Domain of unknown function (DUF3821)	Coggill P	pcc	manual	Domain	This is a domain largely confined to sequences from Methanomicrobiales found on putative lipases. The function is not known.	20.80	20.80	21.00	30.30	20.50	19.40	hmmbuild  --amino -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.47	0.70	-4.66	20	31	2010-03-15 09:40:29	2010-03-15 09:40:29	2	7	7	0	23	31	0	210.70	28	29.50	CHANGED	sGusVFlGEpGLDlosshs......ssspIuWassuss................................ssssPsphhslss..spsFaVsPshFssps....GsWYthssp.t.........sssFpVc-PslulclhDtsssp-lo..spslspGshlsFpI..cTNLtuh...tpRsusssss....lsIplp........sPsGssassLhss.sGssps................Lssls.....Vss.....................ss.tss..suWsTush.ssust.Y.psGsYslhAcsslNsht-	..GssVFlGEpGLDlosshs.......ssspIuWassGsss...............................ssssPsphhslss..sssFa.VsPshFsscs.....GsWYthsss.t..............ssuFhVp-Pslulcla.Dhs...s..s...pDlo..spplspGshlsF+l..-oNL.ul...hpRsusssss....lsIpVp........sPsGsshosLhss.sussts...........lssls.....lss......hah................tt..suasossh.spssp.Y.psGsYpVhAcsslNsMtD..........................................	0	11	23	23
+12703	PF12864	DUF3822		Protein of unknown function (DUF3822)	Coggill P	pcc	JCSG_pdb_3hrg	Family	This is a family of uncharacterised bacterial proteins. However, structural-similarity searches indicate the family takes on an actin-like ATPase fold.	20.40	20.40	21.60	21.00	19.90	19.30	hmmbuild  --amino -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.50	0.70	-5.15	46	193	2010-03-15 14:40:07	2010-03-15 14:40:07	2	1	190	1	54	196	147	238.40	24	89.79	CHANGED	Mt.t................phshpptp.hp....LSIplshcGhSFsl.....hss.spphhhhpphphp....sstpltpplcphhcpp.phLppsacpVpllhssshaThVPpsLF.-ccphssYLpa..s..hhps-hltach.ltp.shssVash.pslpsalhcpass...hcahHpsosllcthh..pts.pstppcplalplpcpph-lhlhcppcLlhhNsFp...hpo.......scDhlYYlLashcQLsls.-psplhlhGp..l..sc..csphaphlppYl+plp	................................................h................s..pppthp..LoIclutsuhSFsl.......hss.ppp..hhhpphphp....sshsl.tssLcphhppp.phLpp.s..acclpllhsss.hsllPhph.F.cc..cpt..pphhpa..shptpps-hlhhsh.Ltp.sssslashscslpphlp-pasp...hcahptsssllphhh...ppu.ttuspcclYsphcccph-lhsapps+LlhsNoFp...hps.......spDhlYYlLalacQLshst-cscLhLsGp..l....sc...c-plhppLcpalcpl.............................	1	22	47	54
+12705	PF12866	DUF3823		Protein of unknown function (DUF3823)	Coggill P	pcc	JCSG_target_3hn5	Family	This is a family of uncharacterised proteins from Bacteroidetes. It has characteristic DN and DR sequence-motifs. The function is not known.	21.80	21.80	21.80	22.20	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.61	0.70	-4.84	28	92	2012-10-02 19:08:27	2010-03-15 16:51:00	2	1	54	3	14	85	2	225.90	25	92.24	CHANGED	hllhhhhs...hsuCp...h.DNY-.tPcutlpG+l..hhsGEslthch....s..usplplappG..a.s...ph..sshslhlppDGoa.sshlFsGsY+llhhpGsh..............stDolp...lslp.Gs.sphDhcVpPYhhl..cssshshsGsplsAoFplppssss.....slccltlalspophVs............s..thsptt.shsshhs.sp.hohplslsps...............pshhasRlGspsssstph..YSpll+l	.....h.hlhhhhhhsSCp...h.DN.YD.tPp..uslpGcl..hhsGEhlthch....s....usplplhphG..au....pp.....ss.shhlppDGoa.sshlFsGsYclhh.pGsh.............hstDTlp...lplp.Gs..sph-hcVpP...Yhpl..pssphph.s...u...splsApaplppssss..................slpcltlalspsphVs....................spphspts.p.hssths.ss.hshphs...lsss....h.s..........tpphasRlGspss.s....s...p....ph.....YStshcl...................	0	6	13	14
+12706	PF12867	DinB_2		DinB superfamily	Bateman A	agb	Jackhmmer:P72629	Domain	The DinB family are an uncharacterised family of potential enzymes. The structure of these proteins is composed of a four helix bundle [1].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  --amino -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.64	0.71	-3.79	220	3722	2012-10-02 14:44:17	2010-03-16 10:45:46	2	34	1437	16	1256	5855	770	137.90	14	54.56	CHANGED	th..ppsh.p...phhph..lp....sl.....s.p......pphphp..s...................................s.sst................slt.hltHlsh.....spp..hhh....tp.ht................................st.................s.....................................h........tht.ht.h.......................................s...........shs.pl........h...phhp.phppphhphlps..h....st..tp....h...pp.h.....hh.....................................................t.h......s........htphlth.hhtHptpHhtpl	..........................................................................t.th.ph..hp....sl.....s..p.......pp..ht.hp...s..............................................................................t..stt......................................olt.hlsH.l.sh........hpc...hhh....hp.ht.....................................s.p...............t.s..........................................................h........t.htp.t.p.h.............................................shp..pl...........h...p.h...h....p.p.s....p.pph...h...p...hl....ps...h.........st....tp.......h.....tp.h.......................................................................................................................h.............s..............h.t.t.h.l.h.h..hhtHptpHhtph....................................................................................................................................................	0	533	952	1146
+12707	PF12868	DUF3824		Domain of unknwon function (DUF3824)	Coggill P	pcc	manual	Domain	This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.	22.70	7.90	22.90	7.90	22.00	7.80	hmmbuild  --amino -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.29	0.71	-3.24	11	83	2010-03-16 14:05:24	2010-03-16 14:05:24	2	6	42	0	63	89	0	114.80	25	27.75	CHANGED	+pRSRoRDLApAALAAsG.lGYAAHKYo.QRp-RKKt-+ER-+.+aDcD.hppSYt-sY.sPhPYssoP........sssspYYPpoNaFPPPPGosPs..ssssstP.sYNPADYPP.......P..PuAs.sP.psYsY....Pss..PusDsYAPRPRRADENV	......................+SR...sRp........huthul..AAAG....hG...hA..A..tp..hp..p++-+K.........cp-..+cR...ccpcpccc.hppuhpp.s..h..ss.ts..ssss...............st.t.h...st....ssh.as.PPs.t........................................................................................................................................................	0	9	22	47
+12708	PF12869	tRNA_anti-like		tRNA_anti-like	Coggill P	pcc	JCSG_target_390051_3f1z	Family	This is a family of bacterial, archeael and viral proteins that is related to the tRNA_anti family Pfam:PF01336. The major characteristic of families like tRNA_anti is their OB-fold, and many of them bind DNA.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.93	0.71	-4.71	25	205	2012-10-03 20:18:03	2010-03-16 14:53:54	2	8	185	10	48	201	46	146.90	15	77.05	CHANGED	Mt............pphlhhhlhl............hhluhlhs...............................sh.spsphsstptpssh...............shsu.ppLhspapcNpspAsppYh.....sKhIpVpGslssI.pc.tttsss..llhtpp.ts.sslhCphsssp.............ts..lppGpplplpGhspGht...........hsslhLcssh	.....................................................................................................................................................................h................hh.hhh...............................................tttt..h..............................................hss.s....plhpsa.p.p.Nt.h.......sA.......s......p.pY.p......sKhlpl.s.G.pl....t..sl..pp..ttssph......hsh.h.s....s..t..t..s........h..sl....p.sthsssp....................t..t.......lppGpplslpGhhpsh.....................h...............................................	1	17	31	40
+12709	PF12870	Lumazine_bd		Lumazine-binding domain	Coggill P	pcc	JCSG_target_391926_3k7c	Family	This is a family of putative lipoproteins from bacteria.  Many members of the family are defined as having a lumazine-binding domain. Lumazine is a fluorescent accessory protein having 6,7-dimethyl-8-(1'-D-ribityl) lumazine (DMRL) as its authentic chromophore; it modulates the emission of bacterial luciferase to shorter wavelengths with increasing luminous strength. The family is related to the NTF2-like transpeptidase family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.32	0.72	-4.02	26	650	2012-10-03 02:27:24	2010-03-16 16:51:30	2	9	571	4	86	427	52	96.70	23	43.48	CHANGED	suC..ssssPpps....scpahcsltcGchcchhchhs.pspp..........th.thhcthspphppphpphtuhc.hcl.ppp.....sspApVplpssatsupppppshpllK.pc.spWplp	...................................................hs...............................t...p.tth.t....................................................................pl....cp.l...cVh-+s.........sDsAcl..+Vch...s......h........s......s.....s........s..s..p......p......p..p.......l.........L...+...c-...upWcl.h............................	0	35	67	79
+12710	PF12871	PRP38_assoc		Pre-mRNA-splicing factor 38-associated hydrophilic C-term	Coggill P	pcc	manual	Domain	This domain is a hydrophilic region found at the C-terminus of plant and metazoan pre-mRNA-splicing factor 38 proteins.  The function is not known.	22.40	22.40	22.50	22.50	22.30	22.30	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.35	0.72	-11.34	0.72	-3.46	72	139	2010-03-16 17:36:41	2010-03-16 17:36:41	2	24	85	0	82	113	0	102.60	25	19.68	CHANGED	s+sssh......c...pc.h..p-tp..ps..p..-...cpt.ccs....s......p......cs....s..ts.hs..ttp............p.s.s..cppsRspp.........................ps..pc.p.ppp...pp...p+p.cs.......cs..pp..R..p+spt......p....pc+....-+....p...Rp.+..sRs...R.......sRsR.D..Rpcc	............................................................................h..shc...ts.hpp.ppt..p..-....-pt.pp................ps....s....s...sp..htp...........................p...tspsRpps...........................................................ph+p.ptp.s.......cp.......sRc..Rs..................+s......pcR.c+sp.......p.....+-R....-R....s.Rc...+.cRc...R...sR.sR.DRcc.t........................	0	19	37	59
+12711	PF12872	OST-HTH	OST_LOTUS;	OST-HTH/LOTUS domain	Bateman A	agb	Aravind L	Domain	A predicted RNA-binding domain found in insect Oskar and vertebrate TDRD5/TDRD7 proteins that nucleate or organize structurally related ribonucleoprotein (RNP) complexes, the polar granule and nuage, is poorly understood [1][2]. The domain adopts the winged helix-turn-  helix fold and bind RNA with a potential specificity for dsRNA [1].In  eukaryotes this domain is often combined in the same polypeptide with protein-protein- or lipid- interaction domains that might play a role in anchoring these proteins to specific cytoskeletal structures. Thus, proteins with this domain might have a key role in the recognition and localization of dsRNA, including miRNAs, rasiRNAs and piRNAs hybridized to their targets. In other cases, this domain is fused to ubiquitin-binding, E3 ligase and ubiquitin-like domains indicating a previously under-appreciated role for ubiquitination in regulating the assembly and stability of nuage-like RNP complexes. Both bacteria and eukaryotes encode a conserved family of proteins that combines this predicted RNA-binding domain with a previously uncharacterized RNAse domain belonging to the superfamily that includes the 5'->3' nucleases, PIN and NYN domains [1].	25.00	11.50	25.00	11.60	24.90	11.40	hmmbuild  --amino -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.54	0.72	-4.14	234	1690	2012-10-04 14:01:12	2010-03-17 11:05:37	2	67	816	6	797	1608	60	71.30	17	19.68	CHANGED	pt.ppltphlpphl..tpspcp....sG.hspluplssphppph..ssFcs+sY..........GappLscLl.p..s.hsch.hcl....ppttssphhl	......................h....thtp.lhpll...t..pttst........t.hh.lupltsphpcph..shs.psY..........GapplpcLl.p....u..hssl..hcl.....tpttt.....hh.......................	0	219	388	594
+12712	PF12873	DUF3825		Domain of unknown function (DUF3825)	Aravind L	agb	Aravind L	Domain	Potential uncharacterized enzymatic domain associated with bacterial Pfam:PF12872 domains.  Has conserved residues suggestive of an enzymatic role probably related to RNA metabolism.	27.00	27.00	30.20	29.50	23.50	21.40	hmmbuild  --amino -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.72	0.70	-5.22	20	92	2010-03-17 11:31:21	2010-03-17 11:31:21	2	5	85	0	15	78	3	224.80	31	63.68	CHANGED	ppLuplAts.E.........sWthsps........pshsILcsYlphTFpRlhcpsp..............hhhssssspusFNTGLlopptcsIaAlFppsp.........................................tsttsWhhpuFs............tsptphhhpshsplP.shusYac.csp-llF..Dsc.tclpls...h-HI..hs-ph..-RhPsphppht....................................cptltshlpuAlchstp+spRNY+hAVPpaYp.......s+lphLLPlpL...spssps-hALslp+..scph....YcupTILTL.chAYpNARLls+P.-scW	....................................................................LtplA....E...Wt.tss...............ILhsYlhthFpplhcppp..............hhhstcps.hAsFNTGLhopth.psIauhFpppp...........................................pttahFpt....Fh.............pptt.hh....plP.phusY..s...t..p-..llF......Dsc...hshpls...h.Hl..hppp...cRlPphlpphs...........................................cphltphlpuslc.......hhtcphphs.+hslPtaYp.......p+l.lhlPLpL...........ppppsDhslVlc+....ppst....YtspTILs..c.sYpsARllshs.-spW................	0	7	11	15
+12713	PF12874	zf-met		Zinc-finger of C2H2 type	Coggill P	pcc	manual	Domain	This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.	21.10	13.30	21.10	13.30	21.00	13.20	hmmbuild  --amino -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.71	0.73	-7.09	0.73	-3.60	388	5348	2012-10-03 11:22:52	2010-03-17 11:37:56	2	907	368	3	3248	16868	203	24.20	29	5.85	CHANGED	hh..CplC.phphsspsshpsHhpu++H	............h.CplC..phphsopsp.hptHhpuppH............	0	719	1232	2244
+12714	PF12875	DUF3826		Protein of unknown function (DUF3826)	Coggill P	pcc	JCSG_target_393061_3g6i	Family	This is a putative sugar-binding family.	25.00	25.00	170.90	28.90	20.00	19.80	hmmbuild  --amino -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.20	0.71	-4.60	7	68	2010-03-17 11:40:38	2010-03-17 11:40:38	2	2	39	2	14	57	0	174.70	46	54.17	CHANGED	tYlcsl.pRupKIVspLslsDssttppVsplIAN+YhcLsDIaptRDs+lKtlKcsh.LststpppAlcttphctDAsLh+sHhpa.ApLShhLs-cQI-tVKDGMTYGsl.lTYcuh.DhlPoLTEEEKtpIatWLsEAREaAMDAcsScKKHAhFsKYKGRINNYLuK+GYDLpKEpc-WhcRhcu	........t.stSl.p+utcIVspLtLsDsptuppVtslIsN+ahclpDhapt+st..ppl.Euh..ssstt.ptLctt.htcsAthhcsHhta.ssLshhLs-cQIEtlKDtMThGhVthThcua.-hlPsLpEEE+upIhtaLhEAREhAlDhcNspph+AhFsKYKG+INNYLsc+Ghsh+pttc-ahc+hKA.....	0	9	14	14
+12715	PF12876	Cellulase-like		Sugar-binding cellulase-like	Coggill P	pcc	JCSG_target_394744_3gyc	Family	This is a putative cellulase family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.91	0.72	-3.54	18	341	2012-10-03 05:44:19	2010-03-17 13:25:12	2	18	274	2	102	613	180	89.30	29	19.74	CHANGED	llspatp-sRIlhWDLaNE.Ps...s...............h.s.ttsst...hct.hthLppshthhRslcPspPlTuGh......sss..........shss......hpplp..hpsl.DlIoaHsY	...........lspatsDsRlLhWDLaNE.Ps..s.t..............................t....ptst........hp...t....s....tp.Llppsh.pasR.slcP.s.Q.P.l.T.u..G.s..................Wps..................phss...................ls.thp......h.p.ps..Dl..loaHsY.............................................	0	39	77	90
+12716	PF12877	DUF3827		Domain of unknown function (DUF3827)	Zenonos ZA, Mistry J	zz2	jackhmmer:Q9HCM3	Family	This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34 [1-2].  Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion [1-3].	19.40	19.40	20.60	20.00	19.10	18.60	hmmbuild  --amino -o /dev/null HMM SEED	684	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.18	0.70	-6.42	5	150	2010-03-17 13:51:21	2010-03-17 13:51:21	2	4	46	0	75	128	0	484.60	41	45.39	CHANGED	PhpPsP-upFQV+TVLQFVPuuVDlRhCsFoQphEKGLhpAa...tEVR+sopushNlTVpIlNIT...slSspsp.p+sPVsIlFAV+sspGFLNGT-VSuLLRQLSAVEFSFYLGYPsLQIAEPFcYPpLNlSpLLRuSWV+TVLLGVh-pplss+sFptohER+LAQLLuElhshu.ppRhRFRRAToVGNsoVQlVpsoRLsGPDNPlELlYFVEttNGcRLsAsuoAclLNolDlQRAAIlLGYRVpGllApPV-+QAcPss-opPNNLWIIlGVVlPVLVVslIIIILYWKLCRo-KLDFQPDTluNlQQRQKLQ.PSVKGFDFAKQHLGQHuKDDlhlIp-PsPL.ss.hccsoPuEsu-lPoPKSKus.pcuoopssR+RGclSPS-uDSpsS-suSsRuus-cusRsussPusssQQ+so+ccupptssPuSGhDEsLSSuSIFEHVDRlSRsuuDus+RlSuKIQLIAMQPMPAPPl.s...s.csStsD+As-NuKVNKEIQsALRHKSEIEHHRNKIRLRAKRKGHYDFPusEDlpuuhGD....spEp-RlYppAQ.QIcKILcPs-cp..SsasEP+KSsRu+RSP+sRR++QsLNGsu...T-tD+DRLIpoDRDGTYR+sPGVcNpAYlusss.plP-spu.S.ocp........spGHsPS.PusLsoQPSIEEuRQQMH.LL--AFALsSPuS	..........................Pt.hhplpT.......VLpFVs.sssht.CpFsQhhEptL.hAh......thhh...ptp.s.hpl......................p.sVslhasVt.stpshLNGo.sS.pLLppLSs..huaYLsYPsLpIAEPhp.YPpLshSphh+s.WVh...T...V.....l.G.......Vspp.lt.p..ptphtRhhtQhLupl.......hht...t......hhh+tssshGs.sVQhVphpR..l.GscsPspLhYas...sGc.L.ustuucllsplD.QRhAlhLtahl..........h.tcPsscs.ssNLWlIsuV.l.hPlhVV..hlIllIlhhhLC....RpsK.-FpPDshhNl.QRtK.............VpGFDaAKQHLGQpstD-.hl.hp.ts.......l.................shP.csu...sp.+phh.......shphtppschp..S.cusSt.sup..Spcput.p.................s.tsht...pt+.pct.......tpt.s..............s..ss..pE...................ths.hs.....................u+s.s-s.cp..suplQLIuhpPhshPss.......p...tspsh.ssclN+.................AL+pKS-IEHaRNKl..RL+AKR+GaY-FPss-s.ps..tc....p...p+h.p...........chh...ssst...usahcs+p....R..phpsp.hRp+Q.lsuss...s-h-..h.hhhppspcGhhpps.ss...ps.hh.....tss....................s.st...........s.......s...s..hhsspPoI-csRppMH.LL--AFuLsuss....................................................................................................................................................	1	8	17	34
+12718	PF12878	SICA_beta		SICA extracellular beta domain	Finn RD	rdf	Manual	Domain	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  There can be between 1 and 10 copies of this cysteine-rich domain [1].	21.70	13.00	23.40	13.10	21.60	12.90	hmmbuild  --amino -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.91	0.71	-4.46	262	470	2012-10-01 20:19:39	2010-03-17 14:32:34	2	34	2	0	456	482	0	170.50	28	62.21	CHANGED	oLCsplpCAup+.a..........hpppptp....ssss.................s...sa.W..pp....hpsclppLhpphspstp....pps......sss.hCsphtsss...............tspspKpACpalsAGLc+l.h......................pt...ssus..................pssp.FcQTMGClhL+tYAKpl+c..pu...............hCsI.-p.......GIc+A....Fpps.p..shhpss......Cs.......sssssCh.Cph......csc..ac...s.CpIs	...........................shCsplpCsspp.a....hppp.ttt...tsss......................ssh.Wpp......hpsclppLhpplspstppss.....sss..hCsshssts..............tspspKpACphlsAGLcclh................ph.......ssss.....................ss..acQTMuChh.LptYAccl+cpu............tC....sI.-p.....GIccA....Fpps.sph.hpss........Cs.......sssssCh.Cph......cps...ac...sCpI.......................................................	1	0	0	0
+12719	PF12879	SICA_C		SICA C-terminal inner membrane domain 	Finn RD	rdf	Manual	Domain	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  The C-terminal domain is thought to remain in the erythrocyte, found juxtaposition to the single transmembrane domain.  To date, all full length proteins contain a single copy of this domain [1].	21.90	21.90	32.80	21.90	18.30	21.40	hmmbuild  --amino -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.66	0.71	-4.30	3	127	2010-03-17 14:33:42	2010-03-17 14:33:42	2	24	6	0	123	132	0	131.10	61	13.13	CHANGED	KYFG.LhR+tRRY...+RuPspAssPSVQEQlLDHVEEAG......PHEYRLVKERKPsSsPsRTKRS.......GtVNRRTIIcIHFEVLDECQKGDTQLNQKDFLELLVcEFMGSEhM.EEEQVPKEEVLMESlshclVPhE-.VPSLSSGFMV	..............................................................KYFGPLGKGG.RF...RRSPs-IP.GsSVQEQVLDHVpp.su........sHEYpLVKERKPRS..u..PTRTKRS...........GtVNRRTIIEIHFEVLDECQK.....GDTQLNQK.DFLELLVpEFMGSEh..M...EEEQ..........VPK.....E-..VL.....M.....E.....ul.....P..........h.....E......VPhE.....c.....VPsLGSshh..........................	0	12	12	17
+12721	PF12881	NUT_N		NUT protein N terminus	Zenonos ZA, Mistry J	zz2	jackhmmer:Q86Y26	Family	This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations [1-2]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [1-2]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein [1-2]. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [3-4]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation [3-4].	18.10	18.10	18.10	18.90	17.30	17.30	hmmbuild  --amino -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.29	0.70	-5.30	4	167	2010-03-17 15:11:40	2010-03-17 15:11:40	2	10	28	0	77	136	0	260.30	49	37.96	CHANGED	sh.GPsMohpPGsuLSsFsALPFhPPsPsPscpP.hEPss.PllsushSPuNPLlLSAhPSs.LVTtpGGsu.SuAGsupVhVpl+T-sGPscsuQsQNllLTQssLshpsPGs.CGGltsP.PP.alTAusVpsllsupsVGsoQ..EG....GLPh..ssPPsAQLsPIVs.tpuhPsPpGspGEGGPsus.ppsS.sDhupts+uVYENFRpWQ+YKsLARRHLsQSPDsEALSCFLIPVLRSLARhKPTMTLEEGL.RAlQEWp+TSNFDRMIFYEMAEKFhEFEAtEEMQIQpsQlMpGsQsLsPsss.+LDP.Gs.APEVspQPVY	...............................t.shshpPusu.ss.ssLPh..PsssPscts.........s.h.ssshsPssPLhL.sshPps.LVstpsu...s...sus..Gssp.lhlph+o-stsspsspsQshlLTQssLshpAPGs...CG.Gs.sP.sP.hhlsAuss..shhsups......lG.soQ..s..-G..s.G....LP.....sPPPsAQLsPIl.s..puhPhPpGspu...EGu.sss.pt.u.sDpSspsKSVYENFRhWQ+aKsLARRHLPQSPDsEALSCFLIPVLRSLARhKPTMTLEEGL.hAhpEWp+pSNFDRMIFYEMAEKFhEFEAtE.......E.......MQhQ.......p........Q..hhpGspshsPsss....+h-P.GssAsclspQPs...................................	1	8	9	20
+12722	PF12882	NUT_C		NUT protein C terminal	Zenonos ZA, Mistry J	zz2	jackhmmer:Q86Y26	Family	This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations [1-2]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [1-2]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS) [1-2], both located C-terminal to this domain. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [3-4]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation [3-4].	18.10	18.10	52.90	20.10	17.60	17.90	hmmbuild  --amino -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.77	0.71	-4.59	5	230	2010-03-17 15:28:47	2010-03-17 15:28:47	2	8	26	0	96	163	0	127.70	39	25.81	CHANGED	PRL+ssRPQ+PPps+sPpEIPPEuVKEYlDIM-.L.G....hTGEScs.+EE-G.spssQEE--LPuDstLLSYpc+LCSQKlFVSpVEAlIpPQFlu-LLSP-sptD.LALppsLEQEEGLTLAQ...LlpK+pPsLcccusAEAsPs	...............................................th...+sp.p.PspsctPp.hPs.ssp-hhDIMp.h.......sG-s.s.pppct..p.tpp.E.E.-.th.sDssLLSYhccLCSQc.FlopV.EAlIcPpFlppL.LSP-sphD...hA....LppcL..EQE..EGL.olAQ..............lhpK.+hh.hcp.t.sct.sP.........................................	1	14	14	23
+12723	PF12883	DUF3828		Protein of unknown function (DUF3828)	Coggill P	pcc	JCSG_target_392985_3kzt	Family	This is a family of bacterial proteins of unknown function.	24.40	24.40	24.50	24.50	24.00	24.30	hmmbuild  --amino -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.51	0.71	-4.19	23	492	2010-03-17 15:29:03	2010-03-17 15:29:03	2	4	451	2	44	225	5	115.80	42	47.98	CHANGED	P-s.sspsFYpaY..lpphsp......spsshtssss.....lccYVupsslpcLpt..ph...pp-hh-uDYFhpsQDass.-Wlsplplspuph.sssshVtVphG.p..spshplhlhlp+EsGtWKIhcVpsss	...............................s.pQsV+phYpsY..hosh..........ssshhs-Tsp...........ct..hsStcl.ptLsLsssL........sshsh..lDhD...PhscsQDauc.hh...l.c.s.lslsp..scs.spu.cAsV.chpl.......h.....ps-cc+ps.....slp..hltE.s.GRWhIs-lsss.c.................................	0	6	14	28
+12724	PF12884	TORC_N		Transducer of regulated CREB activity, N terminus	Zenonos ZA, Mistry J	zz2	jackhmmer:Q6UUV7	Family	This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [2]. The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS) [1]. The coiled-coil structure interacts with the bZIP domain of CREB [2]. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions [3]. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs [2], but the physiological function of the multimeric complex has not been clarified yet.	25.00	25.00	26.30	30.90	23.70	24.10	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.42	0.72	-3.44	13	158	2010-03-17 15:32:13	2010-03-17 15:32:13	2	5	63	0	75	136	0	64.30	56	11.44	CHANGED	NPRKFSEKIALppQKQAEETAsFEcIM+-Vpuo+hspppspppp........................s..s.u.thhGGSLP	.NPRKFSEKIALHsQKQAEETAAFE-lMpDlssTRhpttplppsp...........................spu..paYGGSLP.........................................................	0	15	25	48
+12725	PF12885	TORC_M		Transducer of regulated CREB activity middle domain	Zenonos ZA, Mistry J	zz2	jackhmmer:Q6UUV7	Family	This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [1]. Although the C- and N- terminal domains of these proteins have been well characterised [1-2], no functional role has been assigned to the central region, yet.	21.90	21.90	22.50	24.70	21.30	18.60	hmmbuild  --amino -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.19	0.71	-4.45	10	208	2010-03-17 15:34:46	2010-03-17 15:34:46	2	7	51	0	92	168	0	147.20	52	26.60	CHANGED	RTNSDSALHQSshsPsPQDsFsG.GuQslpspch...lLho................sPstE-s..ph-KcpsKQhW-tKK..ss.ouRP+SC-VPGINIFPSPDQphosSlhPuAHNTGGSLPDLTNIQFPPPLPTPLDP-Ds.sasohSuusSousLssshTHLGIouuup	..................RTNSDSALHpSsMsPssQ-sasG..usps....hh...p+h........hh.s...................................sP..s..h.EEsh..ps-+sh.cQ.W-sKK...os.uSRP+.SC....E....V...PGI....NIFPSs-Qp.sss.sh.hPushNTGGSLPDLTNlHFPsPLPTPLDPE.-s...sas...uLS..uusSTu.NLssshTH..LGIuus..t.................................	0	11	20	40
+12726	PF12886	TORC_C		Transducer of regulated CREB activity, C terminus	Zenonos ZA, Mistry J	zz2	jackhmmer:Q6UUV7	Family	This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [2]. The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs [1].	21.50	21.50	21.50	22.10	20.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.59	0.72	-3.80	8	195	2010-03-17 15:36:07	2010-03-17 15:36:07	2	8	60	0	94	170	0	73.50	55	12.73	CHANGED	PNIILT...........sDSsP..uLSKDluuALAGVsshsaDu-s....FsL-DEL+..l-PLuLDGLpMLS.DPDhhLsDPAlEDSFRuDRL	.....................................PNIILT...........s-.SsP..uLSK.-lsuuLAGVs-hsh...s..s..-s....FsL-..D.EL+..l-PLoL.....DGLpMLs.DPs.h.lLsD.PulEDoFRtDRL....	0	13	21	43
+12727	PF12887	SICA_alpha		SICA extracellular alpha domain	Finn RD	rdf	Manual	Domain	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  This domain is typically found at the N-terminus, with 1 or 2 copies per protein.  The domain is cysteine-rich domain  and similar to PFAM:PF12878 [1].	21.70	13.00	23.20	13.10	20.80	12.90	hmmbuild  --amino -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.20	0.71	-4.54	71	105	2012-10-01 20:19:39	2010-03-17 16:07:03	2	21	2	0	103	131	1	180.80	26	21.68	CHANGED	sssLhppWhpph........hpss...ut.s.spss.........ppIsscL.+cpLcctaccLp..shLp.p.sp.us........ElsshCus.............hsttt.s...ss..t..pp...ph.KplCKullcl+YFMuGlcsppp..........cp.tsthsthpshctYsRClVGtlALsclYG-HCclccllptlpsplc....pplpsp..tspss..........hspCp.s.lshp-lhhG+slLsspIcpW	................s.stlhptWhpph.tts.t.s.s............tplhpcl.+cpLcchaccLp..phLp..t.tpst.........ElsshCss...............hhttt.sst...t..pp....h.KplCKullcl+YahuGlcpptp............cp.tsthpshpshctYhR...ClVGtlA...Lscl..Y..G..-......H......Cclp.cllpplpsplc............pplptptspss..........hspCc..s.lshpcLhh.G+slLtspIcpW...............................................................................................	0	0	0	0
+12728	PF12888	Lipid_bd		Lipid-binding putative hydrolase	Coggill P	pcc	JCSG_target_393040_3h3i	Family	This is a small family of lipid-binding proteins found in Bacteroidetes.	21.50	21.50	21.50	31.70	21.30	19.50	hmmbuild  --amino -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.42	0.71	-4.25	5	26	2012-10-03 05:44:19	2010-03-17 17:49:49	2	1	23	3	6	26	1	114.50	33	67.72	CHANGED	lGAGalphsTYNTAANssTEMWL-D..huNhWssKlKVsVDYsuRTFouTG....lusplsuDsKVslT.....DGKVLcGAATTPSGMPADSIVahlpFsDDssGhTYKVuGFRRTGFPADD	......................................hstthphpTYNTsssssscMWlc............hsshas..h+sKlssDhsupoFssss....hsst....h.psDs...p..lslT.........................-GKVlhsuuTT..uGsssDSIha.hpFosss..GhTYplsGaR+TGastD-..........	0	3	6	6
+12729	PF12889	DUF3829		Protein of unknown function (DUF3829)	Coggill P	pcc	JCSG_target_393163_3iee	Family	This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL_GvpF family of proteins, Pfam:PF06386.	25.00	25.00	25.30	25.30	24.60	24.60	hmmbuild  --amino -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.78	0.70	-5.21	47	668	2010-03-17 18:27:44	2010-03-17 18:27:44	2	4	523	3	45	381	4	246.60	42	80.92	CHANGED	ssspthpKhNsYlp.hhNplt...tshhpshtpYhshhtchcpst.ptpphhh.sh.th.......cpshpthcps.......ht.psshtslDpss.....pshhsshpplh.shhschpsYappcsYpcDshs+ucpL...psplhtthppapsshpshpstlpchpccppttphpt........hcp.pscththtthphh....tpscpl...ht.h.ttpp.tthchtshp................ttlschpptlpshcphhtt.thpt.........thhpshspapssspphlpcl+s...................hh....tsshsphhpsYNphlsshNpht	...................................................tttshscKhssYIc.saNplp.......hsl.pulscYsch......hc..Dh+pGP.TGcEph..lhslhsl..........htpCpcthKps.......sALsPshpslDusA.....luYI-uAsALusTI.NEM-KYYsQ-NYKDDAFAKGKsL...HpohlKsl-sFcslucpYcsuIpchs-c+phspLKp........lE-.pE..GKohp....YYo.LslM.....loAKQI.....NslI.op-p...FDscAhh................KcluELEohls.....phKchspss......................uFlsS.AspYQhpsKKalRRlRDpV.......hpphpssss.uahs.........p-Sastsl+pYNEhVDsYNph............................................	0	13	26	38
+12730	PF12890	DHOase		Dihydro-orotase-like	Coggill P	pcc	JCSG_target_393237	Family	This is a small family of dihydro-orotase-like proteins from various bacteria.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  --amino -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.86	0.71	-4.51	4	46	2012-10-03 00:45:34	2010-03-17 18:34:02	2	1	46	0	6	1447	801	171.40	49	50.21	CHANGED	K+lllshlshLu..LsthuhpAQsLhsT...........TWsAYGloFpAP........................AulsVE-DoEE...........ualhssssaYlTlQhL-uEGhK+.u-LsptLKshAsDDpVTsQouVpsFELPQFaGs.L+G...sCEs-+ClYuhLLsKsuusGFYlSIlYocEs	................................................................................................KLlsPGLlDlHVHLREP.GsptKETIpoGohAA.................................A+GGaTTlsAM..PNT..p.P....sPDphEphp.ltpt....................IpcpuplpVLPauuI.T..V.c.psGpEhsDht..........................sLhchGAF.A.F..TDDGVGV.QsAuMMhcA.MK+AAcL.c.h.A.l.V.A.HC.ED..s..o.L.h.s.p.Gs...V.HE.G...c.hu...c..c..a....G.......L.pGI......PSlC...EoV...H...I.......A......RDl.L....L....A...E......A.A.uC.....H..........YHVCHlSTKp....................................	0	0	4	5
+12731	PF12891	Glyco_hydro_44		Glycoside hydrolase family 44	Coggill P, Bateman A	pcc	JCSG_target_393205	Domain	This is a family of bacterial glycoside hydrolases formerly known as cellulase family J, and now known as Cel44A. It is one of the major enzymatic components of the cellulosome of Clostridium thermocellum strain F1 and of many other Firmicutes.	25.10	24.70	25.10	24.80	24.90	24.50	hmmbuild  --amino -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.85	0.70	-4.86	27	92	2012-10-03 05:44:19	2010-03-18 13:56:41	2	21	82	14	41	96	9	206.30	32	25.61	CHANGED	NtsNuGsDWhaps............sphssPutssspahcpshttGs.hshlTlphhGYVutDs.s.s..hspstshPss+asp.......................lthspssshuhsPc.............hsss.lYhsEa......Vsalhs+..hGsu..sssGl+hYuLDNEPsLWss..............THsclHPpslohsElls+slphA+slKshDPsAplhGPs...taGasuYhshss...sss.......ss..scusap.al-aYLcph..+pspcssGhRLLDVLDlHaYPpup	........................................................................h.NsusDWh.ps................t.suthhpthhpp.sh.t.ss..shhTl.hhGaVutct.........ttshsss+att.......................hh.ttss.hs.sPs.............h.ss.hYhs-a.....lphlhpp.....hGtu....stsulpuYplDNEPs.LWsp..............TH.clHPsssThsElls+shshApAlKssDPsAplhGPu...taGatu..Yts.ts......t.t........sp.....p.sshp.alsaaLcph...+ptpptt.GhRLLDhhDlHaYPps...................	0	25	33	36
+12732	PF12892	FctA		T surface-antigen of pili	Coggill P	pcc	pdb_3gld	Repeat	The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages [1]. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonisation of human tissues [2].	22.30	12.50	22.30	12.50	22.20	12.40	hmmbuild  --amino -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.20	0.72	-3.18	46	1757	2012-10-02 19:08:27	2010-03-19 11:32:17	2	125	375	11	237	1642	91	84.80	22	26.02	CHANGED	YpYslpEp.p..ssh.sG..lsYDs.p.phplsVp.Vs-ssps.thhhs.thhhsh...pt.s.p..pt..sh.tFsNo.a.......sss...s.....Lplp..KplsGps.......cscpF..sFslphp	.................................................apYslpE......h......t....s......s.......su.....lsYDs...t..p.hpl.sVp..Vsc.......p......s..pG.....th.....h......s....h..sp........................tt.t..............tt...................tF.sNs.Y.........................sss....p............hphp.....K.l...pG...t...t.........tttp...a....pF.l...t...............................................................	1	65	125	164
+12733	PF12893	Lumazine_bd_2		Putative lumazine-binding	Coggill P	pcc	JCSG_target_391417	Family	This is a family of uncharacterised proteins. However, the family belongs to the NTF2-like superfamily of various enzymes, and some of the members of the family are putative dehydrogenases.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  --amino -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.59	0.71	-3.55	61	306	2012-10-03 02:27:24	2010-03-19 16:13:43	2	10	241	22	137	612	378	116.00	21	75.47	CHANGED	s-hpulpsslpp.Yh-Ghhpu.DsstLcpsFHscA...tlhsht.pup...hhthshcpa.hshlpsp......tssusshptpIhsl-lsG.ssAhs+lcsphh..sh............papDaLsLl+.h-GpWpIlsKsap	.............................................s.p.pslppslpp.Yh-u.h.....tpu..DsstlcpsFpssu.............th.hshp..psp.............lp..t...h...s.h.sp.a...hshlppt...........ts..tt....t...p..t.p........tpl......p..lcls..u..shAhsclphphh.....st..............................pa....s....Dh........h....s..Ll.K.h-GpWpIlsKha.................................................	0	49	89	114
+12734	PF12894	Apc4_WD40		Anaphase-promoting complex subunit 4 WD40 domain	Coggill P	pcc	manual	Domain	Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,	21.10	13.40	21.10	13.40	21.00	13.30	hmmbuild  --amino -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.08	0.72	-4.46	29	282	2012-10-05 17:30:43	2010-03-22 10:40:44	2	24	200	0	193	362	3	47.10	26	6.94	CHANGED	ph.p.ls-Kslssp........lp...hhsasPpMDLlAluoccsplhlaRL.NhQ+........l.......as	...........................hspp........lp...hhsasPp.hD.LlAlus.........p.cGp...lhlaRl..shp+........lh.......................	0	65	98	152
+12735	PF12895	Apc3		Anaphase-promoting complex, cyclosome, subunit 3	Coggill P	pcc	manual	Domain	Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1, 2]. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20 [3].	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  --amino -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.20	0.72	-3.85	111	1548	2012-10-11 20:01:03	2010-03-22 11:07:53	2	603	877	14	798	4682	1088	82.70	18	13.86	CHANGED	pptpacsAlFhu-+lhshss..........p...psh........ahh....Apshappspa....ppA.hpll..............tphtt.ps...htspY.....Lh.A..pshh.cLpc...ac-AlssLtps	...........................................................................t...tappAlh.hhc+h.hp.sst...................p.....pst....................................hhh........Apsa.app.spa.......pcA.hphhpp...................................hphps..pp.............ps.ta...................lh...u.......pshh..phpc....hc-Alphlp..h.....................................	0	291	477	677
+12736	PF12896	Apc4		Anaphase-promoting complex, cyclosome, subunit 4	Coggill P	pcc	manual	Domain	Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle.  the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism [3].	21.40	21.40	22.60	22.00	20.90	20.00	hmmbuild  --amino -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.18	0.70	-11.14	0.70	-5.03	36	264	2010-03-22 11:31:27	2010-03-22 11:31:27	2	10	228	0	186	273	1	197.50	24	26.91	CHANGED	pLphlthshshh.p..ttphlhplAppssplpsLlpYlppshpplppta..cshhphh....cchhsshtpt..pt................p.tsshs.sphhcllhoGhss..slc-aLh..spLuE+GhK+hp+ssssuapslpcllhppLlsAhERhhllLscLpGlu+ap.t...........ltl.sspplsch......lpsspslhhhsacllhplspEhctF......pt.FhpWlph.hlchhss-..sp	..........................................t...hh.hchphl.p..th.tlhtlApphsplpsLlpYlppshpphpptW......cshh..h......spplsphst...pt......................................................sspsslt.schhcLllhGpsss.tLpp.aLh.......spL.s-..........+GhK+hspulpsuapslpcLlhppL.s...u...hE.......phhhhLu........cLpGhupap.ph....p.........lGL.sss..tlpps...............................lpsssshhlhspcllhslspphppF.......ps.FhpWLhh..l.hhtpp....t.......................................................	0	59	98	150
+12737	PF12897	Aminotran_MocR		Alanine-glyoxylate amino-transferase	Coggill P	pcc	JCSG_target_390749_3ez1	Family	These proteins catalyse the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid [1]. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyse this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  --amino -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.33	0.70	-5.92	5	444	2012-10-02 18:26:03	2010-03-22 16:02:22	2	1	437	8	94	3944	814	413.70	53	97.54	CHANGED	MTssAhsDALspAcAAY-sFKARGLKLNMQRGQPADADFDLSNGLLolLGEsDsRh.DGoDLRNYPGGVAGLPSARALFApYLDVKuENVlVWNNSSLELQGhVLTFALLHGlRGSsGPW..lu-..KPKhIVTlPGYDRHFLLLETLGFELLTVDMQsDGPDlDAVERLAAsDASVKGILFVPTYSNPGGETISsEKARRLAulpAAAPDFTIFADDAYRVHHLhuEu-+DsPVNFVuLuRDAGHPDRAFVFASTSKITFAGAGLGFVASSEDNIuWLuKYLGAQSIGPNKVEQARHVKFLp-YcsGLEGLMRDHAcLIAPKFcAVsEsLcsELG-.GGcYATWToPRGGYFISLDTlDPVA-RVVcLA-cAGVSLTPAGATYPuGpDPHNRNIRLAPTRPPL-EVcTAMcGVAsCV+LAoEEYRAGp+	.............................................................................................................................................................................ho.--Lssh+pplppcYscLpA+sLsLDlTRGKPSscQL...DL.SssLL.s.l....s.s.s.s....hss...-G.s.D.s.RNY.GGhcGlPElRplFuElLG......ls.....s-plIAusNS...S.L.slMa.D.llsau.hla.Gsssut+....PW.......spp....tpV..KFLCP.VPGYD..R.H...FA.I.oE.ph..G...I...EMIs..V...P..M.s...p.....c.....G....P....D....h....D....h....V.....c....c........L.......V.......A..........t..........D......P.........s.....l........K.........G...................h......W.s........VPhY.uN.PsGsoYS--T.VR+Ls.p.M.....p.s..A.A.P.D..F..R..I..a..W..D.N.A.Y..........A..l...H...p.....L...........t....D.t............p.........s.......h............h............s.......l.....L....t........h....u..p.......c...A.....G.N......P.........s.....R...s..a....h..F..A..S.T..........S.K.I.T.F..A.....G...u..G..Vu..F..l..A..u......S...p.........s.......N.........l....s...........W...........a...h...p...a...h....u.h.c...o.I..G...P..D.K...l.N.Q...L...R..H...s.+.F.F....t.....D..s..-.....G....V....+...t.H...M...c...+..H...t...pI...L....A.P....KFt...h....V.h-.lL...-...c....+....L....u.....s.t...s..l...A....o.W..T.c.P.p..G..G..Y..F..I......S....L...D........V...h.......-....G.........T......A..p....R....l...V....u....L....A..K...-...A...G...lu...L..T.s..A...G...A..o.a..P.....Y...t...+...D....P...c...D...+..N..IRlA.PS...a.Ps.l.-ELcsAh-ul.u.s.CV.hLAAsE+LL...pt............................................................................................................................................................................................	0	32	71	88
+12738	PF12898	Stc1		Stc1 domain	Bateman A	agb	Jackhmmer:O94276	Domain	The domain contains 8 conserved cysteines that may bind to zinc. In S. pombe this protein acts as a protein linker which links the chromatin modifying CLRC complex to RNAi by tethering it to the RITS complex. The region is reported as a LIM domain here, but has a slightly different arrangement of its CxxC pairs from the Pfam LIM domain Pfam:PF00412, hence why it is not part of that family [1]. The tandem zinc-finger structure could mediate protein-protein interactions.	24.80	22.00	24.80	22.30	24.50	21.80	hmmbuild  --amino -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.53	0.72	-3.92	21	74	2010-03-22 17:08:22	2010-03-22 17:08:22	2	3	71	0	62	73	5	83.60	29	26.08	CHANGED	KC.tsC+Kh+spssFSp+QLcchp+shhsp..hpshsspshspCppCs..us.pssEL....................pCs.hCs+sKuL-tFSKsQR+c.-ss..+ChsClpt	....................cC.thstchpshstFSppQlcphppthhpp......thhstpshhtCppCs..up.pssEl..............................pCs.hCs.+s+sL-tFSKsQR+p.scss.........+ChsCsp........	0	16	33	49
+12739	PF12899	Glyco_hydro_100		Alkaline and neutral invertase	Coggill P	pcc	manual	Domain	This is a family of bacterial and plant alkaline and neutral invertases, EC:3.2.1.26, previously known as Invertase_neut Pfam:PF04853.	23.60	23.60	23.60	23.60	23.50	23.40	hmmbuild  --amino -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.66	0.70	-6.09	20	347	2012-10-03 02:33:51	2010-03-22 17:10:24	2	7	135	0	171	342	258	358.00	51	75.19	CHANGED	pAWc.lL-colVaYpGpPlGTlAAhDs.ss...csLNYsQlFlRDFVPSuLsFLlpG..csEIVRNFLhhTLpLQupc+plDsap.GpGlMPASFKVh....ctt.....cEhLhADFG-pAIGRVsPVDSuLWWIILLRAYs+sTGDhohucsP-sQpGl+LILcLCLsssF-haPTLLVsDGusMIDRRMGlaGaPLEIQuLFYuALRsAppLLp.ss.....pss.pp..hlppls........pRLpsLshHlRpYYWLDhp+LNpIYRaKTEEYGc.s.u.hNcFNIhP-SIP.sWLh-.WLPpcGGYLlGNluPuRhDFRFFuLGNhlAIlouLAotpQupAIhcLlEp+W-DLlGcMPhKICaPAlEscEWRIlTGsDPKNpPWSYHNGGSWPsLLWhhsAAslK.............sGRsp.lAc......+Alpl.AccRLs+DcWPEYYDG+sGRhlGKQARpaQTWoIuGaLlA+tLl-.sP	..........................................................................................................................................................AhchhcpulV.apGpslGTlAA.D..sp...p.LNYsp.lF.lRDFlPSulsaLhpG..c.-IV+NFLhhoLpLQ..................u.........hc+......................hD.ap.upGlhPASFKl.........p.....tp-hL.sDFGppAIGRVuPVDSuhWWIILLRAYsK.oG.....Dhsltcp.-sQpGh+hILpLCLsc.uFDhaPoLLssDGssMIDRRMG..........laGaPlEIQ.uLFa..AL+suh.phLt...p.....t.ts..pp...hlptls..................pRLpALoaHhRpYaWlDhpplNpI.Y........Ra+TEEYSp.s.A.hNKF.NlhP-p.IP.sW.l.hD.ahPpc..G.G..YhIGNlpPA+MDFRaFsLGNhhuI.lSSLuTscQ.spuIhcLlEt+Wp-L.l..up......M..PlK.I.....C...YPAl..E..s..c..E..W...+...Il...T...G...sDPKNT..WSYHNGGSWPs..L..LW....h..ssAslK.........................hGRsp.....lAc.......+....A....ltl...uEpRL.cD..p....W..P..EY.Y..Ds+pG+a..lGK.QuRhaQTWoIAGaLlu+hhLcsP......................	0	28	99	142
+12740	PF12900	Pyridox_ox_2		Pyridoxamine 5'-phosphate oxidase	Mistry J	jm14	jcsg_3fkh	Family	Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP).  This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.85	0.71	-4.36	153	1956	2012-10-02 11:35:36	2010-03-23 10:43:58	2	14	1393	22	640	2144	210	137.20	22	77.98	CHANGED	cppphhplLc.sshlu+luhss....s....st..PhllPssashs......ssp......lhh+.sus...uu..+hhpshp............t.....sshsstp....hDs...hshsps.........s.a.SVllpGp.uchl...p-spEctpshpthhpph.hPt....ap..thc.......tthtt..sthlclphsphou+t	............................pphhplLp..ps.p.h.s......+luhss....s........st........Phl..lPlsashp.................ssp....................lYh..H..sut.....su..+hhchlp...........................tt....ssh.shsp.....................h.cs........hh...spp.......................tht.a.p....SVl.spGp.sphl.................p..c..t.p....E.p..t..t...ulchl...hp..p....h...sPt.......hp...h..............tt.htt.....ssll.+lphpphou+....................................................................	0	204	440	569
+12741	PF12901	SUZ-C		SUZ-C motif	Bateman A, Aravind L	agb	Aravind L	Domain	The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.	21.10	21.10	21.30	21.10	20.30	21.00	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.64	0.72	-4.27	26	299	2010-03-24 10:52:53	2010-03-24 10:52:53	2	12	94	0	157	272	0	32.90	42	6.69	CHANGED	phpthshssups.p.sVlRpP+GPD..uop.GFphpR	....................tphphssuss...sVlRpP+GPD..sop.GFptpp...	1	27	41	91
+12742	PF12902	Ferritin-like		Ferritin-like	Coggill P	pcc	JCSG_target_390707_3hli	Domain	This is a family of bacterial ferritin-like substances that also includes a C-terminal domain of VioB, polyketide synthase enzymes, that make up one of the key components of the violacein biosynthesis pathway. Violacein is a purple-coloured, broad-spectrum antibacterial pigment.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.78	0.70	-4.75	38	153	2012-10-01 21:25:29	2010-03-24 11:50:23	2	10	120	2	80	218	6	215.90	25	39.49	CHANGED	LppAl.plEhuTlP.YLsAhYSl.csssstp................................stphltslshEEMlHhslssNlLsAlGus.....Ptlst.p.....hPsYPsp.LP..tht...........shphsLtshohsslp.pFhpIEpP-............................................................oIGpFY.psl............hcul...ppLstpht...stsh..........Gc....tcpls.p.a..............stlhsVssh.soAhpAlshIh-QGEGsstss...........-..........sc.uHYh+Fpclhp	...................................LptAlplEhuTlP.YLsAhaSl..psststp...........................................shphlpslshEEMlHhslsuNlLsAl....GGs.....Pplst.th.........hssYPss.LP..th.t..............................shp..lsLtthohttlp...hFht.I...EpPp......................................................................................................t...th.o.IGt.hY.psl............hpsh.......tth.tth.........th....................Gt..........tpp.hh..t..h...........................................................s..h...lp...sh.psshtulp.IhpQGEGss.ss.........................................t.uHa.pF.pl..h..............................................................................................................	1	40	50	67
+12743	PF12903	DUF3830		Protein of unknown function (DUF3830)	Coggill P	pcc	JCSG_target_392654_3kop	Family	This is a family of bacterial and archaeal proteins, the structure for one of whose members has been characterised. PDB:3kop from Swiss:A0JVT3 probably adopts a new hexameric form compared to previous structures. The putative active is near the domain interface. 3kop is most closely related, structurally to PDB:1zx8, where the potential active site is located near residues E51 and Y53 (conserved in 1zx8). Beyond the two residues above, the other residues are not conserved. Also the shape of the active site differs from that of 1zx8. PDB:1zx8 belongs to family DUF369. Pfam:PF04126, which is part of the cyclophilin-like clan.	21.30	21.30	21.30	21.90	21.00	20.60	hmmbuild  --amino -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.04	0.71	-4.82	13	130	2012-10-02 15:38:38	2010-03-24 14:34:14	2	1	126	6	52	135	16	142.90	36	93.05	CHANGED	lTL-KRGVossA+LLD-cAPcTCsAVW-uL..PhuGplaHuKYARNEIYsLlPsFs......sscPstENsTVTPIPGDlsaFsFps..lss.uaGYcssstststss.lsDLAlFYGRNNLLlNGDsGWVPGNVFATIsEGL-....chApACpDlWhsGspGEoLoasRA	.............plsttuhshhAchh--cAPpTstAhhchL...PhpsphhHs+auGptlas.Lss....as.......hts.GhENsTspP.sGDllaa.........................sG.ho-htIhhuhsshhhsuchG.lsGNhFhTI.s.-.Gh-....pltphspclhhcGAps.shp................................................................................	0	12	33	42
+12744	PF12904	Collagen_bind_2		Putative collagen-binding domain of a collagenase 	Coggill P	pcc	JCSG_target_393067_3kzs	Domain	This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. It is the C-terminal part of the PDB:3kzs structure determined from Swiss:Q8A905 (information derived from TOPSAN).	21.70	21.70	22.30	21.80	21.40	21.30	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.15	0.72	-4.20	12	120	2012-10-02 17:35:21	2010-03-24 14:49:05	2	4	80	4	53	113	4	92.40	34	19.50	CHANGED	lPDQSllstsNGcchc+hhATRGpD..YhhVY.sasG+shplchuKIuGcchcAhWasP+sGctphIGpFcN..sstsFpssut...pGsDWVLllcs	.....................PDpSlls.s...t..s......sp+.hs+hlAoRupD..YhhVY.shs.GcshplsLscl.uG......sp..t.sAhWasP+sGchp...h.....l..G...p.h.....s.....s.......s.ht......sFps.Pus...spGNDW.lLllp...	0	28	43	51
+12745	PF12905	Glyco_hydro_101		Endo-alpha-N-acetylgalactosaminidase	Coggill P	pcc	Jackhammer	Domain	Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.	25.00	25.00	25.30	25.30	19.50	19.30	hmmbuild  --amino -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.58	0.70	-5.85	3	455	2012-10-03 05:44:19	2010-03-24 15:08:58	2	39	408	3	19	333	4	408.30	56	27.05	CHANGED	DsKlDWQDGAIAYRKIMp-PlGuE-VsNpVGYRIsMNFGSQAQNPFL+oLDsVKKluLsTDGLGQuVLLKGYuuEGHDSGHPDY.GDIGpRhGGsKDhNTLIccGKEYNApFGVHINAoETYPEAKtFssDhl....DsssuhGWGWLDQuYsINpctDLpSG..pRFKRL.DhLtscsPDLDFIYVDVWssNQ......WsS+QLu-cINDhGWRLuTEaGGuhEpaSTWQHWAuDhsYGG.p.KGINScIhRFIKNHQ+DSWluNaPcVGGsAD+PLLGGaphtsFEGWQoR+Da-ua..I-shFssNLPTKFLQHYpITpWoNsEulc.Ksshpp.......hEssLKDsSsssslslpRK........DshRpRVhTLNGNsIh-Gt.GDcpYLlPWs.cQshKssoA-SEKLYHWNspGGTTTWTLP-GWpussTVYVYELTDLGRTcVKEV	...........................DpKVDWQDuAIAaRs..IMN......N...PpGhEcVt-lsshRIshNFuSQApNPFLhTLDslK+IsLtTDGLGQtlL...L.KGYsuEGHDSuH.sY.us.IG+RhGGhcD......hcs......LIEc.u+KYsAchGIHVNAoEoYPEuK...aF.NE....cIL..............sss..Y..ph...GWsWL..D..QuhpI.Dt.uhDLupG.....cLhch..c.h.K.....+....h....u...........s..s.LD...aIYVDVWGNutp....suWso+hLA...KEINpp.GWRhuhEWupuhEYDSsapHWAADhsYG...G..........h.TNKGh.NSsIsRFIRNHQKDsWlsD...hts.....s.PLLGGhsh..c-FEGWpG+....oDYNuY......lsNlFs+sl.TKahQHaslopWEs...G..s.ss.......ssp.....................hpsplVsssss...c.Vs...Voct.................Pphp.RTlTLN....Gpsl..........cG...............................................uuYLhPWs................sssp.-.KhYYaNspsGuoTWoLPssWAt...opVaLYcLTDQG+sc.t..ph.................................................	0	9	12	17
+12746	PF12906	RINGv		RING-variant domain	Bateman A	agb	Bateman A	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.35	0.72	-3.92	26	1986	2012-10-03 15:03:13	2010-03-24 18:10:39	2	31	326	2	1289	1950	106	50.00	37	10.43	CHANGED	CRIChpstspss........slhpPCpCpGolphVHpsCLppWlsp........psspp.....CclC	....................CRICh...pp.spppp............................Lh.p.PCp.Cp...........GolcalHp........sC....LpcWlpp......................psspp...............CElC.............................	0	402	693	1007
+12747	PF12907	zf-met2		Zinc-binding	Coggill P	pcc	manual	Family	This is small family of metazoan zinc-binding proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  --amino -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.03	0.72	-3.99	13	251	2012-10-03 11:22:52	2010-03-24 18:12:56	2	6	164	0	171	237	2	36.30	39	40.41	CHANGED	slhCclChpTFhsTsststLpEHA-sKHPK..sshpsCFPph	.....hpCplC+...hphss.tp.....h+pHhEuKHPK..ss..................	1	59	101	143
+12749	PF12909	DUF3832		Protein of unknown function (DUF3832)	Coggill P	pcc	JCSG_target_391895_3k6q	Domain	This is a family of proteins from bacteria and archaea of unknwon function. The N-terminal part of the structure from Swiss:Q0AZ30 shows remote homology to the N-terminus of the bacterial toxin/antitoxin 'addiction module', and the C-terminus is distantly related to the TTHA1013/TTHA0281 superfamily.	21.80	21.80	22.40	22.30	21.50	21.20	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.86	0.72	-3.92	12	47	2012-10-02 16:06:15	2010-03-26 16:28:33	2	2	38	4	18	50	1	91.30	29	62.79	CHANGED	L.pshphpsphht-csGpl.olslspl-..lhssusTh-pAhpcLl-sLh-YupDYhschphahp.uPNRppHaPYlh.................plhhps.sp-clppll	........hh..pshphssplhpEsDGol.olsLspl-..lhususoh--AhscLlcsLl-YAcDahs-hphahs.uPNR+cHhPYlh.................plhlpc.sc-plppll...........................	1	11	14	17
+12750	PF12910	RelB_N		Antitoxin of toxin-antitoxin stability system N-terminal	Coggill P	pcc	JCSG_target_391895_3k6q	Domain	This domain appears to be the N-terminus of the RelB antitoxin of toxin-antitoxin stability system or prevent-host death system. Together RelE toxin and the RelB antitoxin form a non-toxic complex.  Although toxin-antitoxin gene cassettes were first found in plasmids, it is clear that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria, and these toxin-antitoxin loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress [1,2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.21	0.72	-4.60	97	364	2012-10-03 00:18:00	2010-03-26 17:37:23	2	5	297	4	132	2153	384	44.10	28	52.34	CHANGED	M......pslsho-ARspLppllDpsspscpsl...IsR.p..sppsslllSh-php	...............M...tphNhp-A+spLopLl.-ps.t.p.Gc.p.sl...I..s..+.t....scssshllshp.....................	0	38	80	111
+12751	PF12911	OppC_N		N-terminal TM domain of oligopeptide transport permease C	Coggill P	pcc	Pfam-B_1473 (release 24.0)	Domain	Oligopeptide permeases (Opp) have been identified in numerous gram-negative and -positive bacteria. These transport systems belong to the superfamily of highly conserved ATP-binding cassette transporters. Typically, Opp importers comprise a complex of five proteins. The oligopeptide-binding protein OppA is responsible for the capture of peptides from the external medium. Two integral highly hydrophobic membrane spanning proteins, OppB and OppC, form a channel through the membrane used for peptide translocation.  This N-terminal domain appears to be the first TM domain of the molecule [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.74	0.72	-4.59	398	11398	2010-03-26 17:47:28	2010-03-26 17:47:28	2	16	3658	0	2635	7363	2094	54.70	23	17.25	CHANGED	shoh.hp..-sW..+Rh++NKhAlluLhlllllllhA.lhu.Phl..uP....a...................sp.s.hs.......ht...hsPu	.......................hp.....phh.......cphh...+...s+...hA.h.h.ulh.l.l...llll.l.hu...l...h...u...Phl........us........a........s.........st.s....hs............h.......sP....................................................	1	740	1563	2104
+12752	PF12912	N_NLPC_P60	N-term_NLPC_P60;	NLPC_P60 stabilising domain, N term	Coggill P	pcc	Pfam-B_845 (release 24.0)	Domain	This domain, at the N-terminus, appears to be the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b1, the third an SH3b2 and the last, the C-terminal region, the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).	21.90	21.90	22.00	22.00	21.30	21.50	hmmbuild  --amino -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.57	0.71	-4.02	25	228	2010-03-29 10:40:00	2010-03-29 11:40:00	2	6	225	2	40	175	4	120.00	31	26.33	CHANGED	hhhhlhsslLh..suCus+ss.s......................h.....tDlphhPQ-hpsYsps..........lhsttpptt.spcapp+aFuPWppspsphstp-lhhshpth...tpppu...YuENhp.hs.shhcshhpsAshcsa	.................................................................hahshhllhh..suCupKshs...............................................pslShLPQ.spshshs..............................sccYp+haF.......uPWcss.hh.....s.....hps.....ps......lFWs.ashh...........hssps.......Yh.Ntp.hshuaacphIpNAslpca............	0	14	33	38
+12753	PF12913	SH3_6		SH3 domain of the SH3b1 type	Coggill P	pcc	JCSG_target_405735_3m1u	Family	This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).	20.90	20.90	21.00	22.50	20.70	20.20	hmmbuild  --amino -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.41	0.72	-4.73	53	435	2012-10-02 18:48:24	2010-03-29 13:38:20	2	10	430	2	70	327	10	52.70	44	11.45	CHANGED	PhFtsPp.sGpGaPF.DhhQpSslhsGoPVhlsHhSpDt....sWhaVpos.hshGWlcu	.............hapsPp.tsEGhPF.DhhQpShLpsGTPVhlhHhS+Dp....cWtaVhos.sshGWVcS...	0	19	49	61
+12754	PF12914	SH3_7		SH3 domain of SH3b2 type	Coggill P	pcc	JCSG_target_405735_3m1u	Domain	This domain appears to be an SH3 domain of the SH3b2-type, and is the second SH3 domain to be found, downstream of an N-terminal domain that is probably the stabilising domain, for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein.  The last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).	21.30	21.30	21.70	21.30	20.60	20.40	hmmbuild  --amino -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.20	0.72	-4.19	41	382	2010-03-29 12:38:44	2010-03-29 13:38:44	2	5	381	2	47	261	5	49.80	32	10.79	CHANGED	scphlppapsh..p.ahsllp-psslh...-ppGpahhpu+lGslhPlhspstst	.........spchlp.atpL...p.hhs.lpsplsla....stsGsaaFpuRhGslhPhhcpcts........	0	12	30	39
+12755	PF12915	DUF3833		Protein of unknown function (DUF3833)	Mistry J	jm14	Pfam-B_259 (release 24.0)	Family	This is a family of uncharacterised proteins found in Proteobacteria.	25.00	25.00	25.50	25.40	20.80	19.70	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.69	0.71	-5.01	105	426	2010-03-29 12:42:56	2010-03-29 13:42:56	2	1	405	0	121	374	1121	163.30	40	91.88	CHANGED	hhs.hhLsuC..uu..slsD.Ytsp.sPphcLcpaFsGclpAaGhlpchsGcVhRRFsVclsusW....c....GsphsLcEcFhYsDGp....pppRlWpLstsus....GpapGoAsDVlGpAp........GptsGs.AlpWpYslcLPl.....-usshpVshDDWMYLhc-ssllN+ophpKFGlcVGclsLshcK	.....................h.hhhLsuC....uu..pls-Y..psp.pPphDLtpaFsGphpAaGhlQDhoG+lsRRFpVslpGph....-....Gs..phsLs.EcFlasD..Gc....pppRlWplp....+t.u-......spYpGs....AsDllG...pAp........GptsGN.AlpWpYshpLsl.....-usshpVpFDDWMYhhD-pplhNcophpKFGlcVGclTLhFcK........	0	24	63	93
+12756	PF12916	DUF3834		Protein of unknown function (DUF3834)	Coggill P	pcc	JCSG_target_400673	Family	This family is likely to be related to solute-binding lipo-proteins.	20.80	20.80	20.80	21.10	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.34	0.71	-5.31	10	19	2012-10-03 15:33:52	2010-03-31 17:06:15	2	2	13	1	18	29	4	188.30	31	82.80	CHANGED	M...........+llsAP..GPVSYPLIAu.hhcpcDl-I..hFuK.cGpuDV..VLDShVSLsKp...Gl+Ishsll+cLhsIhPclup.+IulWRKGSAADlLsRsllDlpsh+uElVYu-D.ppllcMLscGclsoAllu.ushupGcsF.E-Lhpphsl.lPGSCGAhlpsp..-cFIsAYpcGI-hh+pcPEpsA-YIucpLPhphspcFIcsll+pscas	...................................................llsAP..GPVSYPlIsu..hcpcDlcl...FsK...pspuDl..lLD...ShssLsKh...Gl+lshss...lpcLhhlhPplsp.......+IuVWR.+GoAADlLhRhllchpshc.......u...El.VYs-D.tplhcMhppGclpoAV.....l........s...u.hpc..G.th.E-hhs........hPGuCGs.s.ps.....p....pthlssYpcGI-hh+pcPpssA-hluppL..Phhhspchltslhcpsph...........................................................................................	1	4	7	14
+12757	PF12917	HD_2	HD_1;	HD containing hydrolase-like enzyme 	Coggill P	pcc	JCSG_target_394139	Family	This is a family of bacterial and archaeal hydrolases.	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.47	0.70	-4.55	3	447	2012-10-01 20:28:14	2010-04-01 14:05:03	2	2	442	3	51	577	15	210.00	60	97.87	CHANGED	MGIHQYFQSLSDLENIYRCPGKFKYQEHSVAEHSYKVTSIAQFLGsVEEQAGNEVDWRALYEKALNHDYSELFIGDIKTPVKYATPELREMLSEVEESMT+NFIEREIPEcFQslYRahLKEGKDsTLEGKILAVSDKVDLLYESFGEIQKGNPENVFlEIYoEALATIYEFREMASs+YFLKEILPDMLAEKGIEKTELPQLTscIsScuL+.--	.........................................MGlHQYF.ppLSDhEplhRhPGcFKYhEHsVAAHSFKVTcIAQaLusV.E.....E.h...p...Gp.c.INW....K.uLYE.KALNHDauElF.hGDIKTP.VK.YAosEL+chhupVEEcMs.-sFIc.-...EIPtp..ap.-lY+p.R.L......p.....E....G....K.D..Do.L....E..G.....Q....I...L.SV..ADKID.LLYEoFGEIQKtNPE.plFhEIYc.S.L-TIhp.F.-.c.Ls..SVQ.FIppIlPEM.LsEs..F..hs+sc.LpchThsIlp......pcpt..................................................................................	0	16	27	42
+12758	PF12918	TcdB_N		TcdB toxin N-terminal helical domain	Bateman A	agb	Bateman A	Domain	This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile [1]. The function of this domain is unknown, but it may be involved in substrate recognition.	27.00	27.00	27.20	27.80	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-9.05	0.72	-3.90	20	211	2010-04-04 12:49:17	2010-04-04 13:49:17	2	17	131	14	9	218	0	60.70	39	3.43	CHANGED	scYsLhh-slcpc..l.slo-ppp.cphpplpclpctIspYpsh..pcKNS..ppGpsLLppQuplLppl	.s.p.sLh.-slhpt..l.sho-p.hsKhh.pIp-lpclhspYpth.....sKNS..RpGlcLLpcQu-LLctl......	0	3	3	6
+12759	PF12919	TcdA_TcdB		TcdA/TcdB catalytic glycosyltransferase domain	Bateman A	agb	Bateman A	Domain	This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.84	0.70	-6.02	14	376	2012-10-03 05:28:31	2010-04-04 13:55:39	2	24	176	14	22	503	17	327.40	31	26.98	CHANGED	-KplHhlWIuGs.ss-sshsYIphahcs...sDYsahlWhDssAahssphspslhc.Ahstulpplccshs....sspcFhcch.clphch.................................................QcsFhNYshhps.pshs...D-hRhpYLppth.phsp-clppY.............l.cslschhupspscI+shc.h.phpctp.hphYppEhlhRWNhAAASD.lRlhhLKEhGGlYhDlDhhP.......uhsp-lhcsIpc.u...shh.-ssphccshs-ulh+htph..p.......hpshchspLsppspsplppllsphpphs..............clFpslsshhlp-h.s.....p.h.ppuhhssphlNshhlo+KsStssshlIpt.pptYp.Lpchhp...............................................................................................................................................................................................................................................................................................................................................................................................NshsspFhcolsshpshcp...hsh...p.hhhhuhhssYhpDuh...hPcAhSTLslSGPslhstshhchhp.ht..sc.hlhppth+..........................thsahpPpolhupsss.-cpSoWshsct+s	....................................................................................................................................................................................................................................................................lHhlWluGt...s-...pYhp.ahth.......pash.hahD.pAhhh.phpt.lhp.u.p.s.h.th.pt...................h..h..t...........................................................p.h.............D..hh.aL.p.h.th....p..tth.........................t....t...t......l..t.t........h.....................Y.......thh....R.h....N.hsuAoD.lRh.hLpphGGlYhDhD..hhP.........sht.pl.....h............................t......p.h..c.lhphh..........................t.p.s.l.tt...t.h.p.hhtphp................................................................................phF..ht....p........................hth.NthhhshtsS.h.phl..t.p.tY..l.t.ht................................................................................................................................................................................................................................................................................................................................................................................................p.......h.................................................................................................................................................t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	4	13
+12760	PF12920	TcdA_TcdB_pore		TcdA/TcdB pore forming domain	Bateman A	agb	Bateman A	Family	This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region.	27.00	27.00	33.70	34.40	26.00	25.80	hmmbuild  -o /dev/null HMM SEED	663	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.88	0.70	-6.61	18	84	2010-04-04 13:21:11	2010-04-04 14:21:11	2	19	42	0	12	90	0	620.80	33	30.49	CHANGED	hupchssAspcLppcppLsppWlslhsolccpspstYplpFlN..cssspopalpTp-ppFhcapcahpcph.sslspthhh..psGclhtc...tsls-spsVssLNAuFhIQoLIpa......p.suppts.ssLusALKlpsYlshsQhuhGslpDssclspLlppAhptphphhsTt.......hpsh........hupssspGlullhsGsslGhsIaELupAcsslp+shhuTpLuhsusuhssusuulshuhhuu............ussuulLGshuV.luGlulGlsuLspsauhluEcA+uVucYFsplspuhppsua..phpsppp...llhPhssuVlsplDhpsNplpasoptIaps....tpGpotsGphsaFF...........ssssh-cpp.ulsIppulGhsppphphsh.spupshlLPssPpp.hhpYEYshlPGspopcssGhclL...................................++lcpsp.p......F.acFYsFPu-a..sIspl+.cYhsTslclhLDpcsRpLlVPplsc-h.+s+LpYclpGsGGpYpLsLsst.splplss.......ss......psspWIIDsspl...cssoIp..pssplhlGslhhcl..shs.ppshlhhspp-Ip..........................pl-hsspphpl......llutctpphps...............sspslpp....+lppLuhsppLpsphsh......spsh.....ptptpshspsaaDssppchla...h.DssstpsptshhsslssshAahhststtslWtlD	..............................h.hcplssuhhcLpppppLs.cpah.sFpslpc..ss..p...taplpFIs..cpstcshaVpTccphFscatpalscpl.uplppphh...ssGclhtp...hslspsp.......tVssL.NAAFhIQoLIpa............suspts.ssLusAhKVpsYspLhphuhsslpDus+lVpLlpsAlppshsllsTh........pul.........................s..slusllsGl...slGhsIhELucspssl.+t.htspluh.usshssussulh...suu............hshuushuhhhVPLAGlusGl.suLlps.hhl.t-cAppVscY......Fsclshu.ppGsa.....ph.-.cp.......lhhP.sslVIocIDh....sss..p...lhhsp..ppIa+h....soGpTsosslsaFF...........susshshpp..tlsI........hssltlpppphsh.......sp......clhlLPssPpp.hhsaEhsh.hPGh..pohcssGhclL...................................cRlc-ph.c......FhacaauF.u-h......hIspL+.cY.-TsIcIpLDspsRphIlPhlsp-..........h...+pKLSYphhG...uG..GpYtlsLsph.hslslph.........s......csshWllDscpl.....cssoI....pssplphGsll.sl..pl...shpcstlllsppcIp..........................cVDhhs.p.phpl......llus-hphhh................sspplpp....+lshluhssclptshsh......spp......spppt.hspth.-ssh.phla...hpssp...t..hs.hu..hpshpshsh..hthhsuhahhD..............................................................................................................................................................	0	2	4	9
+12761	PF12921	ATP13		Mitochondrial ATPase expression	Wood V, Coggill P	pcc	Wood V, manual	Family	ATP13 is necessary for the expression of subunit 9 of mitochondrial ATPase. The protein has a basic amino terminal signal sequence that is cleaved upon import into mitochondria [1].	21.00	21.00	21.00	25.30	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.38	0.71	-4.78	14	101	2010-04-06 09:10:04	2010-04-06 10:10:04	2	3	99	0	74	100	0	128.60	24	20.08	CHANGED	spphhssllhuhua.GplphlcphlcplWsIsspsp.tt...........hstssshaPopclLhullsua.shspslpsAlpll-pF.cpYs.lcls....cphWccLhpWuthhhsh+tssttphhttshthhtph.pss	............sEphhsslhhuhu+tGplptl.cphl.c.plW.sIsssth.ppst...............ht.ssslaPos+lLhAlspuF.usN.scl.tAlpllDhluppYs..lsls....pphWpcLhpWoalhos.chs.t.ptp....t..........h.......................	0	11	33	62
+12762	PF12922	Cnd1_N		non-SMC mitotic condensation complex subunit 1, N-term	Wood V, Coggill P	pcc	Pfam-B_15091 (release 24.0)	Domain	The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis. This is the conserved N-terminus of the subunit 1.	21.50	21.50	23.10	22.60	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.85	0.71	-4.63	44	291	2010-04-06 09:13:56	2010-04-06 10:13:56	2	14	238	0	204	298	1	161.40	25	13.28	CHANGED	LssphppplhpLlsSulsshupplps.lpss.................-shspa+ptLEhYuaLlhhllphlp.......................t...ts..tt.hssttppppsspssstpWchs.splpphLpslsplLc.lcLs+lFhTos-+DpFls.LFoRsha.hlhEspth..hKspsl+hhlF+lluhuVK+Hupuhssp	......................................................thhpphh-hlhpslushuptlts.lpss..............p..........tsshspat..phLchhs.aLLthhlpshE.........................t.stps..sp...hstt......sp..ppptps....spspsa......chp.sphpthLphls...plLp...L............cLp.+l.atsos..c-pFls.LhTcssY.tlLE.s..ph......hKspsl+.tlh+lLshul++asHhhus....................	0	68	113	170
+12763	PF12923	RRP7		Ribosomal RNA-processing protein 7 (RRP7)	Mistry J, Wood V	jm14	Pfam-B_1057 (release 24.0)	Family	RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly [1].  It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [1-2].	27.00	27.00	31.00	29.20	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.93	0.71	-4.13	61	327	2010-04-06 11:06:40	2010-04-06 12:06:40	2	9	269	0	220	324	2	124.30	31	42.70	CHANGED	GhpcahppYcpp.hss..ptLppplcpahpta-...pccppppcpt.........tp.s.sDE.DGassVs+s..t+t.............sshspsp...htppttttptppc+c+Kphps..FY+FQhR...Ep++pclt-Lh+KFE-DKc+lpthKtpR.+F+Pa	........................................................ttahp.paptp..h.s......ptLppplcpaMpta-pcptpppcct.........ttp..shsDE.DG...alpVs+p...s+p..............................sshspst...........tspt.pht....tptpp.++..c+Kthts..FYpFQhR...Ep++pclspLh+KFEED+p+lp..hh+tpR.+F+Ph......................	0	71	119	181
+12764	PF12924	APP_Cu_bd		Copper-binding of amyloid precursor, CuBD	Coggill P	pcc	manual	Domain	This short domain, part of the extra-cellular N-terminus of the amyloid precursor protein, APP, can bind both copper and zinc, CuBD.  The structure of Cu2+-bound CuBD reveals that the metal ligands are His147, His151, Tyr168 and two water molecules, which are arranged in a square pyramidal geometry. The structure of Cu+-bound CuBD is almost identical to the Cu2+-bound structure except for the loss of one of the water ligands. The geometry of the site is unfavourable for Cu+, thus providing a mechanism by which CuBD could readily transfer Cu ions to other proteins.	26.40	26.40	28.10	28.10	24.80	26.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.24	0.72	-3.46	17	340	2010-04-07 17:32:00	2010-04-07 18:32:00	2	18	84	23	111	306	0	57.50	64	8.54	CHANGED	pCpF.Hhcph...shCpsapcW+ssApcsCps......cshpL+SauMLLPCG.lDhFpGVEaVCCPs	.............KC+FhHQERM...DhCEoHh......HWHTVAKEuCup......cuhsLHs.....YGMLL.......PCG.lD+FRGVEaVCCP......	0	20	27	61
+12765	PF12925	APP_E2		E2 domain of amyloid precursor protein	Coggill P	pcc	manual	Domain	The E2 domain is the largest of the conserved domains of the amyloid precursor protein. The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix, and bears an unexpected resemblance to the spectrin family of protein structures.E 2 can reversibly dimerise in solution, and the dimerisation occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. The high degree of conservation of residues at the putative dimer interface suggests that the E2 dimer observed in the crystal could be physiologically relevant. Heparin sulfate proteoglycans, the putative ligands for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface [1].	21.90	21.90	22.30	23.00	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.24	0.71	-4.73	11	385	2010-04-07 17:34:15	2010-04-07 18:34:15	2	22	91	16	118	340	1	175.40	59	27.13	CHANGED	sssssPsss.sul.DsYFppsssp........sEH..........ppFpcA+pcLEp+HRc+hscVMK-WpEAEcphcsL.+uD.......+pplhp+FQpplpoLEpEusuERppLlETHttRVtAhLN-+RRtAlEsYhsuLpssPPcs++lLpAL++YlRAEpKDRpHol+HacHlpps-P....E+Auph+splhpHLclI--RhNQSLsLLh	....................................h...sTsts.T..DsV.DhYhEsPuD-........NEH..........A+Fp+AKEpLEt+HRcRMspV..........M+EWEEAE...pQAK.NL.P.KAD.......+pslIQHFQph...VcuLEpEuAsE+Q.QLVETHhARV.EAhLNDRRRhAL.ENYlsALQ.u..s..PPRP++Vh.phL++YV......RAEp.KDRpHTL+HapHVhhVDP....cK.AAQh+s..QVh..THL+VI-ERhNQSLoLLY.............	0	21	30	66
+12767	PF12926	MOZART2		Mitotic-spindle organizing gamma-tubulin ring associated	Coggill P	pcc	[1]	Family	FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear [1].	23.30	23.30	23.90	30.60	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.09	0.72	-4.40	12	71	2010-04-08 11:58:30	2010-04-08 12:58:30	2	2	50	0	43	73	0	86.80	47	58.46	CHANGED	Mu...............................s.h.ph.hpptpsLss-Es..ELaELsphAGlslDs-VF+..........................lllDLl+hNVuPhAlhQhLKShCuupths.t......sssspusuh	....................ss..............s.........p....ushQKhul...++KKVLosEEh..ELaELuQAAGsslDP-VFK..........................ILVDLLKLNVAPLAVFQhLKSMCAGQRlusp......st-ssuhs.h.....................................	0	13	17	27
+12768	PF12927	DUF3835		Domain of unknown function (DUF3835)	Wood V, Coggill P	pcc	Pfam-B_14632 (release 24.0)	Domain	This is a C-terminal domain conserved in fungi.	21.00	7.90	23.20	8.20	20.60	7.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.90	0.72	-3.02	55	188	2010-04-13 08:34:32	2010-04-13 09:34:32	2	10	114	0	149	197	0	71.90	25	17.68	CHANGED	lluDtllE+s..............ssstchspphhpcpls.pahch+pthh.t.t.....................................pssPtKhSRFKuu..Rhs	................................................................................................lhcp.......................thp.thh.ppls.....pahch+pphlppps.t........tttpt.....................sl-c................psss.c+...lSRFKuuRh....	0	35	78	128
+12769	PF12928	tRNA_int_end_N2		tRNA-splicing endonuclease subunit sen54 N-term	Wood V, Coggill P	pcc	Pfam-B_644 (release 24.0)	Domain	This is an N-terminal family of archaeal and metazoan sen54 proteins that forms one of the tRNA-splicing endonuclease subunits.	21.10	21.10	21.10	21.40	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.29	0.72	-4.51	49	270	2012-10-01 20:02:48	2010-04-13 10:50:06	2	9	232	0	196	267	0	78.90	30	17.41	CHANGED	MassL.shsRhpph+shshuhap..s....................................................ppptspVsps+GpaapohG..............hs...pts+ha..LhsEEALYLlERGoLplhhss	..................................................phL.s..Rhp..p....p.shs...huh.ah..P...................................................................cpthspl..h.ps.+GpaapohG..............................hs........ppG+ha...LhPEEALYLlEpGolplha..s.....	0	58	101	158
+12770	PF12929	Mid1		Stretch-activated Ca2+-permeable channel component	Wood V, Coggill P	pcc	Pfam-B_1244 (release 24.0)	Domain	MID1 is a yeast Saccharomyces cerevisiae gene encoding a plasma membrane protein required for Ca2+ influx induced by the mating pheromone, alpha-factor. Mid1 protein plays a crucial role in supplying Ca2+ during the mating process. Mid1 is composed of 548-amino-acid residues with four hydrophobic regions named H1, H2, H3 and H4, and two cysteine-rich regions (C1 and C2) at the C-terminal. This family contains the H3, H4, C1 and C2 regions. suggesting that H1 is a signal sequence responsible for the alpha-factor-induced Mid1 delivery to the plasma membrane. The region from H1 to H3 is required for the localisation of Mid1 in the plasma and ER membranes. Trafficking of Mid1-GFP to the plasma membrane is dependent on the N-glycosylation of Mid1 and the transporter protein Sec12. This findings suggests that the trafficking of Mid1-GFP to the plasma membrane requires a Sec12-dependent pathway from the ER to the Golgi, and that Mid1 is recruited via a Sec6- and Sec7-independent pathway from the Golgi to the plasma membrane.	28.60	28.60	29.10	29.00	27.80	28.50	hmmbuild  --amino -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-13.04	0.70	-5.76	34	145	2010-04-13 13:17:33	2010-04-13 14:17:33	2	5	138	0	108	145	0	402.80	31	66.37	CHANGED	hhlalSsNhCppPs.........tssss.spLplYhS....hspss.tstssuphph....hcsGYhpshhp.sss................................slYIuVpu...............sssos................upasYclusSp.sshhapa-s..csalhhVDoDssuALLsTsNLTssstssts.pphht...............s.Yolasa..shs.cs.ths..uLppSaCAlpssspl.......hsstshps.......................ShTsRus......u....+pQFYlsGLNsSosYhuaLs..............stshsssGGtVapshpFsT+s.................sssCuLlasLsFCspVAYuVPusssh...............stspLsphYDshAtulYpNFohuLpQlsCsssscupYS.h+sCsDCssuYKsWLCAVoIPRCsshsss.salp..........................................tspssoRNshIschIpP.ssYhElLPCh-lCaslVRsCPushGFsCPs....s.hlstSYshcs...sss.hTCNYlGssh	..............................................................................................................................................thlalSuNhCtpPt...................t.stssspLplYhS............hpps....s.ts....ts....sp.sh......Fp.pGahth.hs..sss................................slYlultu...............sss.sp...................................................................................hsu.asaclusS..sshhaphcs.....pshlhhlDoDssuALL.TsslTss.s...st.........pph....s...............s.ashash....shp.ss.thp..GlppShCulpststl........htstshps................................................................uhTpRG........................s.....+pQFalsGLNsSosYhuhLs............pt.....tss.shsssGGtVapshpFpT+s........................sssCtllasLsFCspVAYuVPussph...............ststLuphYDshApshYtNFopuLpplsCsssspshYShspsCsDCtpAYKpWLCuVoIPRCs-h.sss....salt.............pt...........................................hspssoRNs.hI.s..phIpP..usYhElLPC.-lCaslVpsCP.ushGFsCPp....sthhp.SYshtt.....sss..oCsY.Gss.................................................................................	0	27	59	91
+12771	PF12930	DUF3836		Family of unknown function (DUF3836)	Finn RD	rdf	Manual	Family	Family of uncharacterised proteins found in Bacteroidales species. Test.	25.00	25.00	26.80	25.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.66	23	146	2010-04-13 15:35:07	2010-04-13 16:35:07	2	1	61	1	16	108	1	125.20	32	86.98	CHANGED	MKspslhKsllhsuhhhsoslsssAsu....p.ssaIYNpEppsGhlsucTlaKh-.G..phLppah+YsYpYD-psRlopKcAhKWNss+spWpshaplsYs.Yssp..-lsssYucWNp++psYshshppoVY.phDs	..................MKspshhKsll.h.sAhlhssshssssps....t.sshIaNp-.p.psshllupslY+h-..G....ptLspahKYsYpYD-ppRhspKcAhKWsuscppWts..hplsYs..Yssp...plshsYscWNsc+psashsschoVh.h.s.s............	0	2	14	16
+12772	PF12931	Sec16_C		Sec23-binding domain of Sec16	Wood V, Coggill P	pcc	Jackhammer:O14029	Domain	Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.99	0.70	-4.67	37	648	2010-04-13 16:54:12	2010-04-13 17:54:12	2	27	269	2	424	664	2	240.20	24	17.51	CHANGED	plhshL.s....Gc+-+AlhhAlcpR.WuaAhllu......Ssls+sh....WppVlp-Fl+.c-h.p.suss.......h...p........LuslaplFuGNhcpul-E.Lsss..................s.t..hs.ts...............W+-sluhlLsN.....+ss.p....sp..pulhs...........lGcLLsphGphtAAHlCalhA...tssh........s.sts..h...h..s..ss...s...shh.hlG...........h.ps.cuhLho........ElYEauhol........ss...h.....s...hPHLhs....aKLhHAhsLA-hGhpscAppYCDsIuusLK.uts+pS........h.hph...pLh..ppLp....c.lusph....p....s...s....s...o...SWl....SKPsh-KV.Gpl.tpFspFluGD	......................................................................................................h.hpphLlhGph..c.pAlphshcpphaucAlllA...pth...spch...atp.shp....pahppp........t..................p................l.pslht.....lhusph...ps.h.ps...hs..................................................hts...........................................W+ppLAhl...lo.s.........tss..s........p.t...ps.l.ss...............LGc.pL...t...p...c.......G.........h...h...p...uAphCYl....h..A.....ts..sh...................t........h.....h...s...p..p......sphshlu.......................................ph.hs.....csl.hs.........................................E.hhEaspsl............ss.p.h....hlssh.s...hK.h...YAphL.A-hG.hhs..pAhpYhphl.t..h..............................................................................................................................................h...............................................................................................................	0	106	230	333
+12773	PF12932	Sec16		Vesicle coat trafficking protein Sec16 mid-region	Wood V, Coggill P	pcc	Jackhammer:O14029	Domain	Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway [1].	23.00	23.00	23.30	23.90	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.54	0.71	-4.14	58	342	2010-04-14 13:53:08	2010-04-14 14:53:08	2	8	218	2	231	328	0	110.60	28	6.82	CHANGED	stPlhpaGhGGpllsshP...s.................st.sshhpsssuplclpslpsllsssp.................thppFPGPLhst.................KoKKKDlhpWLpspIsthppt...............................stpcpc-chLLWclLclhlc.psGs	.............................ashhpFG.GGpllpshP..........................................s.stp.spsu..Vclcshcsllppst..t...................phpsF..PGPLhpt.................cs+KcDlhpahppphsphtps...............................phtcpcsphLLWplLhlLscpsG...........	0	52	104	174
+12774	PF12933	FTO_NTD		FTO catalytic domain	Bateman A	agb	Jackhmmer:Q9C0B1	Domain	This domain is the catalytic AlkB-like domain from the FTO protein [1]. This domain catalyses a demethylase activity with a preference for 3-methylthymidine.	27.00	10.00	27.20	15.80	26.00	9.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.79	0.70	-5.24	8	102	2012-10-10 13:59:34	2010-04-14 15:13:07	2	3	51	1	40	84	3	255.40	57	61.02	CHANGED	Ds-.FtpshpssYsGFllDsPssLPscLHc-VppAFcoht+cGpFh+DlVpsGsK.lohT.VSRsLlG-pGhTY+Y.cLRLFAhPWss--p.......................chttshcshpRLN-hLspcopphLcchsssph.ssshpupCE..........................aNVTLINhM-P.ptpspstLK-EshFGMGK...hSVSWHpDSuLp-pSTVAVYppost..cs-...............cssWpVAL+.uhDttT.......PuLtlPLcstssYYMhcDFNuTHcHAVLsGsos.RFSSTHRVAhs	...................Ds-.Fap.Wph+YsKLllRcusolPE-LHccVQcAFLTL+KHGChF+DLVR...IpGK..DlhTPVSRlLIGsPGCTYKYLNTRLFTVPWPscGsphKYsp........................................s-ItsACpshlKLNDYLphEolpALct.s....ht-p...ppss.s..s.t....thh.ts.............................tp-.hshpsRsuYNlTLLNaMDP...tpMsYLK-EPYFGMGK...MAVSWHHDE..NLV-RSsVAVYsYSCE...s.-tpspp.....................................................phcGRDPshWHVGhKluWDIET.....................PGLAlPL+QGDsYaMLDDLNtTHQHCVLAG.pP.RFSSTHRVA-C.......................................	0	8	11	20
+12775	PF12934	FTO_CTD		FTO C-terminal domain	Bateman A	agb	Jackhmmer:Q9C0B1	Domain	This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans.  The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure [1]. This domain is alpha helical with three helices that form a bundle [1].	27.00	27.00	31.20	31.10	18.20	23.30	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.23	0.71	-4.69	8	94	2010-04-14 14:20:04	2010-04-14 15:20:04	2	3	55	1	41	75	2	134.40	57	31.48	CHANGED	sTapYI+sRCppALpslsshpsps..........s.thpsh-ssslphhtElHpEVEFpWlR.FWlQGsRHAppHc.YWpptIAELspuWcpMEtshphlLsc.l+pusp.......os-ppscsasslLhsLpEpp-LRcEastRspusAatsLPsDQ+PsshP........taD-ss...PLPFDLcsVIspLcppp	.......................GTL-YIhpRCplALQNlps-scss..........shSLKShEsuVlKQsEEIHN..EVEFEWLRQFWFQGpRYpKCTD.WWspPMspLEthW+KMEthophlLpp.l+pct...........................................s.cppschhsslL..LptRppLRpEWttRppsphhptlP.pptP.shP........happ.pp...PLPhsLp.hl.tlpt..h..........................	0	7	10	20
+12776	PF12935	Sec16_N		Vesicle coat trafficking protein Sec16 N-terminus	Wood V, Coggill P	pcc	Jackhammer:O14029	Domain	Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region [1].	20.30	20.30	23.60	23.60	17.00	16.60	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.08	0.70	-4.50	14	66	2010-04-14 15:49:59	2010-04-14 16:49:59	2	2	59	0	47	69	0	218.80	25	12.80	CHANGED	sshWss...tussp-sstcFFsQlpoQTKPI.............ahPsE.sE....SRaEEGhPLlDpsst.........ssPs-pst.pssplDslFstDcs...............s-sutFFsphpps.s.p.tpsssplpRKsToQVLsShpsst..s...uPhS................sPsup..asphLs..ssstp..ptp..cs.S..--sLutp...E.....h.p...p...sE--..............LAtRWpAhL-sD..D.DLLl-D-h.t........t.tph.stss...stssttsls.....SPhsosp..s.spPhhts..sYTP..............H	.........................................t.....t....s...ptt..F.sp.psQshPh.....................................hs.E.s-....uRaEEuhPLlssspt...........shppst.ttstl-shFptDts...............s-pusFFsp.t.t......p.....pp..s.sshp+KsT.QVLsohphpp.....p.ushs...............ttst.sp.....p.sp.l....ststp...hp....p..p..t-phttt..........................tp...................sE--..............LAp.+....W.p....AhLts..D..D..DlLlDD-h......................ttp..stss.....ss.s..h.s.....p.hsspp..s...tPh.t.......YsP.........................................	1	6	15	32
+12777	PF12936	Kri1_C		KRI1-like family C-terminal	Wood V, Bateman A	pcc	Pfam-B_8372 (release 7.7)	Family	The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus [1]. This is the C-terminal domain of the family.	25.00	25.00	37.90	37.70	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.13	0.72	-4.04	58	317	2010-04-14 16:07:41	2010-04-14 17:07:41	2	6	275	0	236	318	6	94.60	36	14.27	CHANGED	hccph-chl-EhapL-h--hl.........ssthssR........FKYRcVsPps.FGLosc-ILhA.DDppLNpaluLKKhAsYRscctch....+-p+chp++t+hcch++csh	.................p..cphEphl-c.hhpLDhE-ll........sc.hssR..............F+YRcVsPss.FGLosc-ILhA.DDcpLNpasuLKKhusYRscctch...........c-p+phpcKt..c.pph+cph.........................................................................................	0	84	133	196
+12778	PF12937	F-box-like		F-box-like	Wood V, Coggill P	pcc	Pfam-B_22368 (release 24.0)	Domain	This is an F-box-like family.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  --amino -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.40	0.72	-4.23	369	8154	2012-10-02 00:56:31	2010-04-14 17:42:23	2	360	366	19	5916	10186	51	47.30	25	8.94	CHANGED	hspLPsElllpIh.................s....h.....L.s..sp..-.........Lhp.s.u.....tVC+pWppls..tcs.tL.W+chhhp	.................................................tLPsE..l.l.h.p.Ih................................................................................................s.........a.......................L..s.....sp.......s..............................L.hp..s..u.................tVC...+p.Wp.pls....tss...l..Wpph...t...................	0	2058	3220	4628
+12779	PF12938	M_domain		M domain of GW182	Coggill P	pcc	Pfam-B_71410	Domain	\N	21.90	21.90	21.90	23.90	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.84	0.70	-4.55	11	119	2010-04-14 16:45:07	2010-04-14 17:45:07	2	12	69	0	70	104	0	239.10	38	16.86	CHANGED	sHsu.u.tsshussc..........asuGuu..suhsFspNs.....sshuusssssGsG..ssNssls...ulssh......caLs..ps..............ushss.usuGupssGuushsustss...t.s.....tpu.QPSspQlRhLVQQIQhAVpsGaLNsQILNQPLsPQTLhLLNQLLs.pIK.......................pLQtsQpsLpRttsu...........................pshplsltIsphKppIssLQNQIss......pQulalK....t.....t.....................t..hupuusshhtspsshssLpsph	..........................................................................................s.tts...t.sa..p...........uuhh...ttsssu..hsssshp......u..suhs.s.tth.thhst.thQs.........................................Ghhusuuuupupsh..p.p...ss..t...PsstslsusQPs.........hpupsPphh....S.ph.AQ.LQhAs+shtLNsuLLTpP.Is.PQphshLNQLhQ.Qls.......................+LQl..Q.QQhLQs.ptNsot.............................cppppQVuhsIsshpQQIQQhQpQlA........QALhhKQ............................p.shpssuu+SuhDsF....s.s+sphsuL.s...p..................................................	0	16	24	51
+12780	PF12939	DUF3837		Domain of unknown function (DUF3837)	Finn RD	rdf	JCSG_target_388609	Domain	A small, compact all-alpha helical domain of unknown function. This domain is currently only found in Clostridiales species. 	25.00	25.00	28.70	31.00	23.50	21.80	hmmbuild  --amino -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.31	0.72	-4.02	6	18	2010-04-22 13:29:43	2010-04-22 14:29:43	2	1	18	0	3	18	2	102.20	34	95.09	CHANGED	MlohIsKQAlslKsphp..AshsuNYEhYYAlGlhuKuhslshsctchs.hEL+-pL-pclct.p..PtDEp.phLhtlLpcac.sDDsaDtQMhELhpaGhpscp	MlopIA+QulhIKsp.hp.puslTuNYEhYYAsGlluKhhGlshs-......chpshELp-pLppclcphp..PpDEp-+hLhplLpsYc..s--shDpQMhELlpaGhp-p.........................................	0	1	3	3
+12781	PF12940	RAG1		Recombination-activation protein 1 (RAG1)	Mistry J	jm14	jackhmmer:Q6U1Q1	Family	This famiy contains recombination activating protein 1, which is the catalytic component of the RAG complex.  The RAG complex is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [2].  RAG1 mediates DNA-binding to the conseved recombination signal sequences (RSS) [3].  Many of the proteins in this family are fragments.	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.50	0.70	-6.13	3	12026	2010-04-22 13:54:52	2010-04-22 14:54:52	2	13	8629	0	36	11047	0	335.50	71	76.21	CHANGED	LLPGYHsFE........WpPPLKsVSsSTDVGIIDGLS.GhssSV-Easl.-sIu+RFRYDAALVSTLKDLEEDILEGhpcQGL--su.StlFTVVlKESCDGMGDVS.EKHGSGPhLPEKAhRFSFTIMsIoVK+cDGsslpVFEEsKPNSELCCKPLCLMlADESDHET.TAILGPllAEREAMKsScLhLEIGGloRsaRFIFRGTGYDEKLVR-VEGLEASGSsYICTLCDATRsEAuQNLVhHSITRoHoENL-RYEhWRoNPYNESsDELRDRVKGVSAKPFlETpPS...IDALHCDIGNAsEFhKIFQcEIGEVY+..NsNsTKEERK+WQotLDKpLRKKMNL+PlMRMNGNFARKLMTcETVEAVCELVpsEERREALRELlcLYlpM+PVWRuspPAKECPDLLCpYSa+SQRFAcLLST+FKYRY-GKITNYLHKTLAHVPEIIERE	...................................................LPGaH.FE........WpPsLKNVSsshpVGIIsGLS.Ghs.SlDDhPs.DTIs+RFRYDsALVsALKDhEE-IhEGh+tpsl-D.h....susFoVllKESCDGM.GDVS.EKHGuGPAVPEKAVRFSFTlMsIo.........l.....................h.......t.s..............p............-.............s.................l....p.............I.FpEsKPNSELsCKPLCLMhsDESDHETLTAILuPllAERcAMKpScLlLphGGl.RoF+FhFRGTGYDEKhVREhEGLEASGSsY...lCTL..........C.DuTRhEASQNhVhHSITRSHsENLERYElWRoNPapESsDELRDRVKGVSAKPFhET.Po...lDALHCDI....GNAsEFY+IFQ..EIGElYp.......pss...so+EER+pWpssLDKpLRKKhpLKPhMRMsGNaAR+LMotEsV-sVCELl.sEE.Rp.ALpcLMpLYlpMKPVWRuosPs+-CP-.lCpYSapSQpFA-lLuo.FpYRYtG+ls..................................	0	8	10	17
+12782	PF12941	HCV_NS5a_C	DUF3838;	HCV NS5a protein C-terminal region	Mistry J, Bateman A	jm14	jackhmmer:A1YSL9	Family	This is a family of proteins found in the hepatitis C virus. This family contains the C-terminal region of the NS5A protein.  CC The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525.	25.00	25.00	29.00	28.90	18.90	24.90	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.77	0.70	-4.80	17	15967	2010-04-22 15:12:44	2010-04-22 16:12:44	2	30	112	2	0	9643	0	185.50	77	38.13	CHANGED	SHITAEsApRRLuRGSPPSLASSSASQLSAPSLKATCTspssHPDAELIEANLLWRQEhGuNITRVESEsKVllLDSF-PLsAEh.DDRElSVuAECaRPsRPKFPPALPIWARPDYNPPLlEsWKtPDYcPPsVpGCALPPts.PPVPPP.RRK+sVpLDESsVSpALApLAcKoFspsssssct.SssGhsssosssssssstsDssSDssSaSSMPPLEGEPGDPDLSSGSWSTVSpE-D....VVCC	...................SHITAEsAtRRLARGS..PPSlASSSASQLSAPSLKAT....C.....TT...+....H....D....S.....P....DA....DLI.EA....N....L....L.....W....R....Q....E.M....GGNITRVESENKVVILDSFDPLpAEE.DE.RElSVPAEILRKSR.+FssAhPlWARPDYNPPLLEoWKcPDY.PPVVHGCPLPPspuPPlPPP.R+KR.TVVLTESTVSoALAELATKoFGSSpoSu..............hs.sssssss.......................................................................t.S.-.s.t.........................................................................................................................................	0	0	0	0
+12783	PF12942	Archaeal_AmoA		Archaeal ammonia monooxygenase subunit A (AmoA)	Mistry J, Finn RD	jm14	jackhmmer:A7U5N3	Family	This is an archeael family that contains ammonia monooxygenase subunit A.  Ammonia monooxygenase is an enzyme that oxidises ammonia to nitrite and nitrate, thus playing a significant role in the nitrogen cycle.  Ammonia-oxidising archaea (AOA) are widespread in marine environments [1].	25.00	25.00	33.70	33.50	20.80	18.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.03	0.71	-4.50	8	13679	2010-04-22 16:07:26	2010-04-22 17:07:26	2	1	283	0	2	13456	21	177.80	85	90.34	CHANGED	VAsNSTLhTINAGDYIFYTDW.....AWTSFVVFSISQShMLsVGAhYYhsFTGVPGTATYYAhIMTlYTWV...AKGAWFA.LGYPYcFllsPsWlPSAhLlcLuYWAT++NKHuhILlGGsLhGLSLPLF....NMVNLLhVpDPLEsAFKYPRPTLPPYMTPIEPQVGKFYNSPVALGAGAGAVLoVshAALG	..............VAVNSTLLTINAGDYIFYT.DW.....AWTSFVVFSISQohMLsVGA.....sYYL.hFTGVPGTATY.YAhIMTlYTWVAKGAWFA.LGYPYDFIVsPVWIP.SAMLLDLsYWA.T++NKHu.LILhGGsLVGhSLPLF....NMlNLlhVtDPLEsAFKYPRPTLPPYMTPIEPQVGKFYNSPVALGAGAGA..VLoVshAALG.................	0	1	1	2
+12784	PF12943	DUF3839		Protein of unknown function (DUF3839)	Mistry J, Finn RD	jm14	jackhmmer:A2DDZ9	Family	This is a family of uncharacterised proteins that are found in Trichomonas.	20.00	20.00	22.40	21.80	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.70	0.70	-5.21	3	2523	2010-04-23 10:20:04	2010-04-23 11:20:04	2	6	1	0	2523	2523	0	188.50	85	78.54	CHANGED	TTuPNSLVMNP.TSMLVEMKsFIPSSFTFETEIQKIKQELLTSsLDCoAKDETNEQYLYEMQDIIDHLPKLPEIQQQKLTIPEFDEItVKsTDSAEIKKFIRKVNsEFLGFHCNHKVMDKDCDMVYKNISDIYKSEEFKTYDNFVSLVAcCVWEIRDKDKRGKVWNEQIKPTsSELKKTIDALVVLAGQISMYNAKMNPQCSKCKAAIRKYNYSVKEIERMRNDYADLKKEAEKPAEDKMNML	....................TTuPNSLVMNP.TSMLVEMKsFIPSSYTFETcIQKIKQE.LLpusLDCoAKDEpNEpYLYEMQDlIDHLPKLPEIQQQKLTIPEFDEIEVKsTDSVEIKKFIRKVNYEFLGFHCNHKVMDKDCDMVYKNlSDIYKS.tEFKTYDNFVSLVAcCVWpIRDKDRRGKVWNEQI+PAhFEhK+sIDALVVLAGplS.YNAKMNPQ.C.SKCKAAhRKYNYSVKEIERMRNDYADLKKEAEKPAEsKMDML.................	1	2523	2523	2523
+12785	PF12944	DUF3840		Protein of unknown function (DUF3840)	Mistry J, Finn RD	jm14	jackhmmer:Q1H8S6	Family	This is a family of uncharacterised proteins found in hepatitis A viruses.	25.00	25.00	37.80	37.70	23.40	19.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.39	0.72	-4.18	2	2908	2010-04-26 15:16:45	2010-04-26 16:16:45	2	5	19	0	0	947	0	80.40	91	47.07	CHANGED	LSFSCYLSVTEQSEFYFPRAPLNSNAMLSTESMMSRIAAGDLESSVDDPRSEED+RFESHIEsRKPYKELRLEVGKQRLKYAQEELSNEVLPPPRKhKGlFSQA	....................FYFPRAPLNSNAMLSTESMMSRIAAGDLESSVDDPRSEEDRRFESHIECRKPYKELRLEVGKQRLKYAQEEL....................	0	0	0	0
+12786	PF12945	YcgR_2		Flagellar protein YcgR	Mistry J, Auchincloss A	jm14	jackhmmer:Q9KNC3	Family	This domain is found N terminal to Pfam:PF07238.  Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias [3].  This family contains members not captured by Pfam:PF07317.	21.60	21.60	21.70	22.10	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.85	0.72	-4.10	119	585	2010-04-27 15:34:41	2010-04-27 16:34:41	2	3	451	5	179	481	9	88.40	21	37.67	CHANGED	lphGpplp.l....ph.....tss....ttt.....hp.opl..luhpps.thlhlshP.....hhsstthhlh..pGptlpl+hhspss....lhsFpoplhp..hh..ppPh.hl..hlshP	...................phGpclp.l....pl......psss........tpp.......hhhp..oplluh.....cps..thlllshP.....hpsspthhhp..pGhtlplchhssps......lhtFpoplhp..hh..pcPhshlhlphP...........	0	70	123	158
+12787	PF12946	EGF_MSP1_1		MSP1 EGF domain 1	Bateman A	agb	Jackhmmer:P04933	Domain	This EGF-like domain is found at the C-terminus of the malaria parasite MSP1 protein. MSP1 is the merozoite surface protein 1. This domain is part of the C-terminal fragment that is proteolytically processed from the the rest of the protein and is left attached to the surface of the invading parasite.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.15	0.72	-4.17	15	1331	2012-10-03 09:47:55	2010-05-02 12:25:03	2	13	39	10	19	696	0	36.90	71	6.05	CHANGED	sCls.sssPpNAGCFRassGpEEWRCLLGaKK..-usp..Cl	.......pClc..ppsP-NuuCaRaLDtpEEh+..CLLsaKp..EGsK..CV............	0	8	9	15
+12788	PF12947	EGF_3		EGF domain	Bateman A	agb	Jackhmmer:P04933	Domain	This family includes a variety of EGF-like domain homologues. This family includes the C-terminal domain of the malaria parasite MSP1 protein [1].	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.66	0.72	-3.99	174	4024	2012-10-03 09:47:55	2010-05-02 12:53:04	2	685	140	8	1803	4138	79	37.60	36	6.42	CHANGED	Ctssss..sCcspApCsNosG.......s.......asCsCp...sGapGDGhs.C	.............Ctps.s.s...sCc..s..s.A.pCp.pssu..........p.........................hsC.p.Cp......sGah..G..-.Gh.C...........	0	749	845	1435
+12789	PF12948	MSP7_C		MSP7-like protein C-terminal domain	Bateman A	agb	Jackhmmer:Q95VZ1	Domain	MSP7 is a protein family the malaria parasite that has been found to be associated with processed fragments from the MSP1 protein in a complex involved in red blood cell invasion.	27.00	27.00	28.70	33.70	21.00	25.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.71	0.71	-3.89	21	213	2010-05-02 13:01:12	2010-05-02 14:01:12	2	1	10	0	31	191	0	128.40	38	35.71	CHANGED	lKalDpLaD............................-lLss.pspKsplcsspa............+sKYNpF+ccY-...shNppEYcIlK+Llssahppsstss.ttsslh.......clFKKuLpDccapccF+NFlaGlYuFAK++NYLs......................sp+hps.pc.YpplFcNslsL	.................lKhlDcla-............................-VLpp..spcsclssspa............psKYs-FKKca-.F.slNppEY-IIKpLIhsFhpcsspspptpsclh.......plFhKsLcDcca+cpFKNalYGlYuaAKp.+sYLp..................................tc+hcs.cc.Y+plh-pshsL....	0	8	11	27
+12790	PF12949	HeH	SAP_2;	HeH/LEM domain	Mistry J, Sazer S, Wood V	jm14	Manual	Domain	This is a HeH domain.  HeH domains form helix-extended loop-helix (HeH) structures.\	      This domain is closely related to Pfam:PF03020 and Pfam:PF02037.	28.90	28.90	29.10	28.90	28.60	28.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.09	0.72	-7.38	0.72	-4.40	47	275	2012-10-03 03:04:30	2010-05-04 14:05:07	2	13	241	1	131	254	0	34.40	38	7.90	CHANGED	ssoLpVscLRplLsp+slpaPusAKKupLlpLhpc	.....psLTVscL+slLsppsl.sasusAKKu-LltLhp.......	0	35	72	115
+12791	PF12950	TaqI_C		TaqI-like C-terminal specificity domain	Bateman A	agb	Bateman A	Domain	This domain is found at the C-terminus of the TaqI protein and is involved in DNA-binding and substrate recognition.	27.60	27.60	27.60	27.70	27.50	27.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.61	0.71	-4.35	40	635	2012-10-02 00:09:28	2010-05-04 17:03:46	2	18	482	22	163	675	44	141.90	19	16.42	CHANGED	hslLpG.....cs.lp+Yplpas..................spYlsat.cthppsp...................................cchac...........p.KIll..Rplus.pls....usaDpcshhshsshhhlhhpstt..................lshchllulLNSclhp.aaapphh.p...tphh.+lphppLpplPl	.................................................................................h..hhcG......p.s..Ip+a.t.h.p.h.s.....................................t.al...h.h.....pthpptp.................................................................................................................tphac.................ptKIlh...tphss...cst.........FshD.s...p.....s...hhh.....p.......ss........sah..lh..tt...............................hs.h.ca.L.lu.lLNSclhp.aah..cph.htth....tssh..h..chptp.lp.plPl......................	0	70	132	152
+12792	PF12951	Autotrns_rpt		Autotransporter-associated beta strand repeat	Bateman A	agb	TIGRfams:TIGR02601	Repeat	This model represent a core 32-residue region of a class of bacterial protein repeat found in one to 30 copies per protein. Most proteins with a copy of this repeat have domains associated with membrane autotransporters (Pfam:PF03797). The repeats occur with a periodicity of 60 to 100 residues. A pattern of sequence conservation is that every second residue is well-conserved across most of the domain. These repeats as likely to have a beta-helical structure.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.49	0.72	-4.24	713	7020	2012-10-02 14:50:22	2010-05-12 12:53:43	2	164	932	0	1415	6703	697	31.50	41	9.95	CHANGED	uLsKsGsGTLs.L..o...G..sNT..YoGuTsl.suGoLplu	..................LsKsG.s.G.o..Ls.L...o............G....sNo..........Y.......o..G.s...T.....sl.s.u.G.oLtl................	0	364	771	1068
+12793	PF12952	DUF3841		Domain of unknown function (DUF3841)	Bateman A	agb	Jackhmmer:Q189I4	Domain	This presumed domain is around 190 amino acids in length. As yet no function has been given to any member of the family.	27.00	27.00	27.40	27.30	25.70	26.80	hmmbuild  --amino -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.31	0.71	-4.81	31	186	2010-05-13 13:05:00	2010-05-13 14:05:00	2	1	139	0	28	161	0	172.10	25	88.45	CHANGED	plaTtQscpshcplccsGhhhs+cE...Ylchchtp.u.hahpsYcWhlccupctl.shPpsscaPlWh..............uhpsctsh.p.ssssllLpLclPp-pllhh-hpcWshlLNhtYlspc-pDcttacchl....cphGltpphphh.o...thYPpl+pclpcSWcR.............................lF.........sttshs.ptlpuslWcl++E.Wlh	.................hlaThQsppshcplccpGhh.hsppc....alp............p.hhhuY..cWhV+ph.cp.+l...s.....pspaPIWsh...............ssppctsh...p...s.......pchVlLpLclPcchllhoshchWshhhspt.hhs...ppp..-ppthcchh....pp.th............hh.t........hsphh.phpcSac+................hF......................................t.tt.t.....ptlpus.Wp.++E.hl.................................................................	0	11	21	23
+12794	PF12953	DUF3842		Domain of unknown function (DUF3842)	Bateman A	agb	Jackhmmer:Q189S9	Domain	This short protein is found mainly in firmicute bacteria. It is functionally uncharacterised.	25.00	25.00	31.40	31.30	24.00	20.90	hmmbuild  --amino -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.54	0.71	-3.99	37	142	2010-05-13 13:13:52	2010-05-13 14:13:52	2	1	128	0	53	126	4	128.70	46	92.09	CHANGED	+IsVIDGQGGGIGppllcpl.+cphsc..l-IlALGTNuhATusMLKAGAscGATGENAllhsst+..ADlIlGPluIlhAsuhhGElTPtMApAlupStApKlLlPls.+ssh.ll...GspspPLscll-phlp.clp	.pIsVIDGQGGGIG+pllcpL.+cphsc.......lcIlALGTNulATusMLKAGAscGAoGENAllhsspc..sDlIlGPluIlhssuhhGElTPtMApAlupSpApKlLlPl.s.+ssh.ll...Gsp.stPLschlcphlp.l.t...	0	36	50	51
+12795	PF12954	DUF3843		Protein of unknown function (DUF3843)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1].	25.00	25.00	119.70	116.80	18.30	17.40	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.32	0.70	-5.43	12	103	2010-05-17 00:57:42	2010-05-17 01:57:42	2	2	61	0	10	91	1	236.70	27	97.99	CHANGED	h+IYhKsWLplHshspshsTDpaYlshAN+lhslhcpo.Lh.shpt...pKplslhhAhYhEDsIushGhW+tFhptHppLYG+YLPFYshs-sYhsDEINhEDIpFlLWshhp..thht.tctsh.sPh-tslhchAphhYslh-cpaEpAP.s-phsphahs.sphhpt...........................................................................................hss..stpstpchscphcpFhpuopG+.LlYFssYc-LppFhlcsLpWpsccsphLPphppp+pFllaAss.KGlLlutslscYhsDccNPhYsucpAtppuachFs..hhCP.DLL+Yshp+slLPDAQhP......suKcll+cNWDFIARaaLtEY	............p.Whthp.h.t...sD.aahthAsplh.hh............l............thsl.hshahpDhlst.G.Wp.F...h.t.Ysp.LPFY..t....t............Yh.sElN.EDl.FllWth.p................P.s.s..thu..hathhpt.ap.AP.st..t..h...................................................................................................................................................................................................................................t...t.ht.hhthstst.hhahtt.tth..Fhhp..th..t....t..hst....tthhhhss..p.Gh..l...p.s.hhtp..Ns.Y...s.t.Attpuh..hhh....h.s..h...h.tpthls-h.h.........tpthhpp.hcFlsc.............................................................	0	2	8	10
+12796	PF12955	DUF3844		Domain of unknown function (DUF3844)	Bateman, Wood V	agb	Jackhmmer:O74728	Domain	This presumed domain is found in fungal species.  It contains 8 largely conserved cysteine residues. This domain is found in proteins that are thought to be found in the endoplasmic reticulum.	27.00	27.00	29.80	38.70	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.56	0.72	-3.92	32	106	2010-05-17 16:38:42	2010-05-17 17:38:42	2	1	104	0	83	109	0	102.90	41	23.96	CHANGED	CasSpcuCspuTssCSGHGpChcp.tst..............cCauCpCpsoh.pp..t......Koh.pWuGssCpK+DlSs.FaLlshsollllhhlsuuIthLaulGp-cLPuVluA	.CasSpcuCppuTssCS.GHGpChpp.tst..............tssCauCpCpsThspptt..t............+sspWuGssCpKcDlSs.FaLlssholsLlhhlshuIshLaulGpEcLPGVluA.....	0	25	47	72
+12797	PF12956	DUF3845		Domain of Unknown Function with PDB structure	Ellrott K	kellrott	JCSG structure PDB:3GF6	Family	Member PDB:3GF6 has statistically significant similarity  to TNF-like jelly roll fold may indicate an immunomodulatory  function[1] or a bioadhesion role[2]	25.00	25.00	479.30	479.10	17.60	15.20	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.56	0.70	-4.97	3	18	2010-05-17 17:26:20	2010-05-17 18:26:20	2	1	18	2	1	17	0	243.60	89	95.08	CHANGED	hIMNKIIGhAVLLLCLoGCVRDNDAIYYPVGNVDIERGGPALEVGpculLVARSYNEEDYVLDTLAQYPGDPTLGKLTFMINLKNQSuDQEVA-FNGVGKSKLTMSLGYKDGNYPVESQVPVYTSuDVTASYAIKLRLKGELTLTGDEWMIDYVYAQLAGLFQPYPPASFPEVFMCKGGEQsFuTFDSFRRTWTFDITYDRS-LSFSQLYFNLFVNLAGQKRE-RVRLRIDKESYFEIYKpKEEM	.hIMNKIIGLAVLLFCLSGCVRDNDAIYYPVGNVDVERGGPALEAG.KGDLIARSYNTEDYVLDTLAQYPGDPTLGKLTFMIsLKNQpADQEVsGFNGVG+SKLTMSLGYKDGNYPsESQVPVYTSSDVTASYAIKLRLKGELTLTGDEWMIDYlYAQLAGLFQPYPPTSFPEVFMCKGGEQsaATFDSFRRTWTFDITYDRSNLSFSQLYFNLFVNLAGQKRE-RVRLRIDKESYFEIYKEKEEM...	0	1	1	1
+12798	PF12957	DUF3846		Domain of unknown function (DUF3846)	Ellrott K, Bateman A	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain is found associated with an Pfam:PF07275 like domain. This suggests that this family may also be involved in evading host restriction.	24.60	24.60	24.80	24.60	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-10.11	0.72	-4.26	53	201	2010-05-17 20:05:53	2010-05-17 21:05:53	2	10	147	0	52	192	71	95.20	25	44.35	CHANGED	psLllpPsptsts.....hplsss...........LcslQphV......GG.IEslhh..........sc.s....sslhlN-EG+hpuLP.hNpthst...............tth.hhDhlsGshllsG...sspss.hs...sLssctl	...................................sLhlpPtp.s.h.....hpltss...........LcshQphV......GG.IEs.lhh.................pc.s....ssllsN-EGKhpGLP..lNcthts...................t...hh-hlsGshhlsG.....ppptp.hh..sLs.t................................................	0	30	42	50
+12799	PF12958	DUF3847		Protein of unknown function (DUF3847)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1].	40.00	39.00	40.30	40.10	39.70	38.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.91	0.72	-4.22	40	356	2010-05-17 20:46:12	2010-05-17 21:46:12	2	1	216	0	14	212	18	83.20	36	80.67	CHANGED	cp.LEpLppEhE+uEp+Lccsppc.KtLcpQhKpLp...............RKcRTHRLCTRGuhLEShl.csccLTD--lh.LLchIFppp-sp-hL+	...........................pph-cplcpt-cclKpLpNpp+pLcp....t....-....RKpRs+RLIp+GAlhESlhpE...sp-LTc-EhhpLlctl.t.......................	0	6	13	13
+12800	PF12959	DUF3848		Protein of unknown function (DUF3848)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain frequently seen with DUF3849.	30.00	30.00	30.00	35.10	26.40	29.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.39	0.72	-4.05	3	58	2010-05-17 21:43:24	2010-05-17 22:43:24	2	2	36	0	3	54	8	98.70	65	39.48	CHANGED	-LNTALYEKMoAEQ-KFRDWLKSQPPEEILNHAYEYTVREDIVMAMEELELTDAQAQALLDSPSPLADVYRYFEKVETDYMDsIRDCIEsRADDVCRAQcE	.........-LNTALYEKMAAEQDKa..RDWLKSQPPEEILpHsYEYTlREDIVMAMEEL.E.LTDuQApALL-SPSPLADVYRYFEKL.ETGYMDs.IRDSIEsRADDVCRApEE..............	0	2	3	3
+12801	PF12960	DUF3849		Protein of unknown function (DUF3849)	Ellrott K	kellrott	JCSG-Joint Centrer for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain frequently seen with DUF3848.	25.00	25.00	26.10	28.60	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.64	0.71	-4.21	8	86	2010-05-17 21:44:30	2010-05-17 22:44:30	2	8	49	0	8	81	12	131.00	42	25.96	CHANGED	PlYpHsAsYApE+sEL-tYRsSppsNhuCKEAIEsAIp-HYssNRLc.cuAVcpVlEpFGhERshaVLAsTlQpp-aDGRaSpsNK-WA+slshPss.ssh....sctshhhVssspPGLlDLFhcpsR+shtppQp	...............................................................PlY.aSAuYApEcGEl-pYRASppsNlpCKcu...IEtAIppcacs....pLs.csAs+sVlEpaGhERVpaVLANTlQpp.-aDG.RhSpcNK-WAKoIssssspsst....pths.ht.hh.ssspsGllDLFhcptR+phptpp.c.........	0	6	8	8
+12802	PF12961	DUF3850		Domain of Unknown Function with PDB structure (DUF3850)	Ellrott K	kellrott	JCSG structure PDB:3IUW	Family	The search results from NCBI sequence alignment indicates a conserved domain belonging to ASCH superfamily [1]. Dali searching results show that the protein is a structurally similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia coli.  Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the biomolecule of protein NP_809782.1 should be a dimer.	30.00	29.00	32.20	37.80	29.20	26.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.37	0.72	-4.01	10	184	2012-10-02 17:37:24	2010-05-18 18:54:59	2	3	161	0	15	153	9	73.00	46	53.09	CHANGED	HsLKItPEaFpAVlEGpKsFEIRKNDRNaQVGDlLlLpEassG..pYTG+tspuEITYITD....YuQ.p-sYVVLSh+	......HcLKIhPcYFc..sVhpGpKpFElRKNDRsapVGDhLhL.......pE..a..p.p.G.............pYT.Gcp.......htscITa.l.T.D........asp...p-.....GYVlLulp......................................	0	2	8	12
+12803	PF12962	DUF3851		Protein of unknown function (DUF3851)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	23.00	23.00	210.20	210.10	22.40	21.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.62	0.71	-4.13	4	33	2010-05-18 21:24:42	2010-05-18 22:24:42	2	1	27	0	1	22	4	124.70	69	99.32	CHANGED	MKspILppcpMMFFDRAL-sQRotLLTsMADAVSECRTAADQAsELNEsGEsGLhRLsEIWsshhstcGhu..hllEGopsplLu-VVAQlYAYLotp.hhDPlGLAlYsELpaMMuSLMLGEWFE	MNPNILNpNPLMFFDRAVNAQRSQLLTVMADAVSECRTAADQAAELNETGQlGLLRLAElWSsIRAKEGMG.GLlLEGTEAKILSDVVAQFYAYLSGCMFNDPVGMAIYAELHYMMSSLMLGEWFE	0	0	1	1
+12804	PF12963	DUF3852		Protein of unknown function (DUF3852)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain frequently seen with DUF3848.	25.00	25.00	25.70	27.70	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.65	0.72	-4.02	10	46	2010-05-18 21:55:23	2010-05-18 22:55:23	2	1	31	0	11	44	3	106.80	63	97.58	CHANGED	KpKKhhhl.hlsVLlLshhFsssAYAuss.GDVAGAIEGTWpsASsQIKTVVNpVVFPAIDLILAVFFFuKLGTAYFDYRKHGQFEWAAPAILFACLVFTLTAPhYIWQILGM	...................KhK+hhhhlsllLlLshhFsssAaAAs.s.GDVAGAIEuTWssASsQIKTVVNpVVFPAIDLILAVFFFuKLGhAYFDYRKHGQFEWuAPAILFACLVFTLTAPhYIWpILGh..	0	9	11	11
+12805	PF12964	DUF3853		Protein of unknown function (DUF3853)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1].	22.10	22.10	22.10	22.50	21.90	21.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.19	0.72	-4.18	8	97	2012-10-04 14:01:12	2010-05-18 23:13:38	2	2	62	0	5	95	5	90.60	54	87.14	CHANGED	sLpcLLpKPVWpMTGEELlFLh++u....sppEscos.psspss-++aVYGIpGIARLFGCSlPTANRIKKSGKID+AITQIGRKIIVDA-LALELAs+c	.....................lppLLtKPlhQMTGEEhlFLtp+u......ppsc..sp.s.tssscs-++YVYGltGIA+LFGCSlPTANR....IKcS.GKID+AITQl.GRKIIVDA-LALELAG+K..............	0	2	5	5
+12806	PF12965	DUF3854		Domain of unknown function (DUF3854)	Ellrott K, Bateman A	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1]. This domain is likely to be related to the Toprim domain.	21.60	21.60	22.10	21.80	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.67	0.71	-4.50	54	235	2012-10-01 21:47:57	2010-05-18 23:31:30	2	15	148	0	78	233	13	113.00	26	15.36	CHANGED	FWpWVhpp.pIPlhITEGuKKAuuLLStGasAIuLPGIhsGYR..+cph....h.t.pL.lPpLthhApsGRclhlsFDp.DoKscThtsVppAlp+hGpLlpptGCpVpl..lpWs..t.tKGVDDhI........sspGtcsa	...............................................................................lhlsEG.hKs...th...h............p.........sh..slul......Gl.sh............t..................................l...hs.Lt...h.s.......s..+plhlsFDt..D...h.pp....ppVppAl.hchu....phL.pp.t.G.h..p..Vhl...........hs..Ws......s.sKGlDDhl........hst.....h.................................	1	16	59	75
+12807	PF12966	AtpR		N-ATPase, AtpR subunit 	Dibrova DV, Galperin MY, Mulkidjanian AY, Finn RD	rdf	[1]	Family	Membrane protein with three predicted transmembrane segments, two of which contain conserved Arg residues. AtpR genes are found in the N-ATPase (archaeal-type F1-Fo-ATPase) operons and are predicted to interact with the conserved Glu/Asp residues in the c subunits, regulating the assembly and/or function of the membrane-embedded ring of 'c' (proteolipid) subunits (PFAM:PF00137).	26.00	26.00	26.00	26.00	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.04	0.72	-3.84	38	110	2012-10-01 19:47:47	2010-05-19 14:12:51	2	1	103	0	51	134	7	85.70	30	84.35	CHANGED	hshhhulhsGhlLGhhaFuuLWhTl+phhsuppPshhhhhShLhRhulslushhh...l.....sssthttLLsshhGFlluRhlhlp......h...hpsp........t	...h..hhluhhhGhshGshaFsuLhhssR..........hhl..sup...sshhlhho.lhRlulslushhll.....upu..shttLlush.hGFhsARhlsl+hh...st............	0	16	35	44
+12808	PF12967	DUF3855		Domain of Unknown Function with PDB structure (DUF3855)	Ellrott K	kellrott	JCSG structure PDB:1O22	Family	Family based on orphan protein (TM0875) from Thermotoga maritima that has been structurally determined as PDB:1022. The TM0875 gene of Thermotoga maritima encodes a hypothetical protein NP_228683 [1] of unknown function. Analysis of TM0875 genomic context reveals the presence of MMT1 (a predicted Co/Zn/Cd cation transporter) and an inactive homolog of metal-dependent proteases. 1O22 shows weak structural similarity with the phosphoribosylformylglycinamidine synthase 1t4a (Dali Z-scr=4.6), the yggU protein (PDB structure:1n91; with DALI Z-scr=3), and with the thioesterase superfamily member (PDB structure 2cy9 - found using FATCAT), even though they have very low sequence identity.	27.00	27.00	307.40	307.20	25.10	23.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.04	0.71	-4.68	2	5	2010-05-19 16:59:37	2010-05-19 17:59:37	2	1	5	1	1	5	0	157.80	81	100.00	CHANGED	M+LMDSLEIhYh+KsK-htsLE+Kh+EIhpETGloL-sVNSE.hGRIFL+IsVLE-tEplPSFhlKALhPcpsAscLPLG-WssLp.VFVEEhsYL-sYs.MKIhS-tNhYTlYVPaSuVKpKNRsElVt-FMKYFFEoKGWsPGpYpF.VQElDslh	MRLMDILEILYYKKGKEFGILEKKMKEIFNETGVSLEPVNSELIGRIFLKISVLEEGEEVPSFAIKALTPKENAVDLPLGDWTDLKNVFVEEIDYLDSYGsMKILSEKNWYKIYVPYSSVKKKNRNELVEEFMKYFFESKGWNPGEYTFSVQEIDNLF	0	1	1	1
+12809	PF12968	DUF3856		Domain of Unknown Function (DUF3856)	Ellrott K	kellrott	JCSG structure PDB:2HR2	Domain	TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).	27.00	27.00	27.00	28.70	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.75	0.71	-4.37	10	11	2012-10-11 20:01:03	2010-05-20 00:48:56	2	1	11	6	10	16	0	144.00	56	82.41	CHANGED	KPL+EVAtAYhALS-AE+pLp-Gta-EAAtSsR+AM-hSRTIPsEEAFDHsGFDAhCHAuLSuAhutLGRY-EuLpSA-cAL+YFNRRGELpQDEGKLWIAAVFSRAlAL-ulGRp-EAlptFRhAGEMIAERKGEhsGKEpLh	....................KPL+EVAtAYhALS-Ap+pLpsGta-EAAtssR+AM-hSRTlPsEEAFDHsGFDAhCHAuLusAhutLGca-EuLpSA-cAL+YFNRRGELpQDEGKLWIuAVaSRAlAL-ulGRt-EAlttF+hAsEMIsERKGEhsGKEph.h....	0	1	1	7
+12810	PF12969	DUF3857		Domain of Unknown Function with PDB structure (DUF3857)	Ellrott K	kellrott	JCSG structure PDB:3KD4	Family	This family is based on the first domain of the PDB structure PDB:3KD4(residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase (3ebi, Z=10, rmsd 3.6A for 152 CA, seq id 12%), despite lack of any significant sequence similarity.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.74	0.71	-4.68	94	529	2010-05-20 21:30:11	2010-05-20 22:30:11	2	34	361	2	180	535	31	170.10	15	23.93	CHANGED	plp.ssGshph.thphshplhsppGlcph.uphpl..sa...ssphpp..lplhpuplhpssGp..h.clsss..t.hhphpt.tshtt.hasstpphh.lshsslpsGs.hlchpaph...............psps..shhsstasshhthpht............PstchphplphPsshslphpth....ts.stsp.pppsst.pha...paphcpl.shh..Es	...........................................................................................tst.s..hhphtlplhspsulcph..uphpl..........a........stphpp..........lplhpsps.hp...s..sGp...h..p..plsss...p..htshpt.t.st..stshasst.....ct....hs.l....shPslcsGs...h..lchp.aph...............ptpp...shh.sha..h.t.h.h..h...hp..t............PhtptphplphPtp..hslphphh.......s.st.p...p......tsst..phh..phphpph........t.............................................................	0	81	124	159
+12811	PF12970	DUF3858		Domain of Unknown Function with PDB structure (DUF3858)	Ellrott K	kellrott	JCSG structure PDB:3KD4	Family	This family is based on the third domain of the PDB structure 3KD4(residues 410-525).  It is structurally similar to part of neuropilin-2 (Z=4.6, rmsd 3.6A for 83 CA, 7% seq id).  This domain and the second domain appears to be part of peptide-n-glycanase (1x3w, 2g9f).	27.00	27.00	27.60	32.50	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.32	0.71	-10.45	0.71	-4.31	6	27	2010-05-20 21:56:00	2010-05-20 22:56:00	2	3	27	2	6	31	0	115.80	41	20.73	CHANGED	YthhsLPpA+sGhAuhs..hshlNocRssNLLLPtLsDEsYTYhVcssssMcssTssppKcIsNsVGplslTV+ppucchcVsRoL+LpKQhITPAEYssa+pLMoEWtDssspoLLF	...............YhlhsLPstcsGlus.t..hsthNScRosNLLLPuLs-EsaTYsVssspGMc.sTsshcKcIsNslGplslolpspusphcVhRoLcLpKQhITPu..-YssaRpLhsEWtsscspoLla..............	0	3	5	6
+12812	PF12971	NAGLU_N		Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain	Moxon SJ, Bateman A	agb	Pfam-B_6295 (release 7.7)	Domain	Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2]. The structure shows that the enzyme is composed of three domains.  This N-terminal domain has an alpha-beta fold [3].	25.00	25.00	27.20	25.40	23.40	23.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.93	0.72	-4.31	33	349	2010-05-23 13:20:51	2010-05-23 14:20:51	2	28	248	5	145	351	5	87.10	28	10.19	CHANGED	ptsuspsllpRllstcupp.Fphclhss.....stDtFpl..ss.......ssuc...lhlpGsssl...ulusGLpaYLKahC......tscloW..Gsp..lcL.....PpsLPhl	............................ssspsllpRllstpspp...Fphp....lhps.t.........spDhFpl.ss..............pss+...lhlpGsssl...ulAsG........LpaYLK.as......tsploW....s.usp..lpl.......PtsLP................	0	53	90	122
+12813	PF12972	NAGLU_C		Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain	Moxon SJ, Bateman A	agb	Pfam-B_6295 (release 7.7)	Domain	Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2]. The structure shows that the enzyme is composed of three domains.  This C-terminal domain has an all alpha helical fold [3].	25.00	25.00	27.20	26.60	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.04	0.70	-5.01	34	392	2010-05-23 13:23:40	2010-05-23 14:23:40	2	27	266	5	168	383	11	256.40	28	31.60	CHANGED	pWlppYucpRY.....Gt.pstplppAWphLhpolYssst.ssttps....pslhstRPsls.........................................spsphhYsspclhpAhclLlpsus....phpssssacaDLlDlsRQsLu.ptupphhhphhpAYppcDhtphpttuschl.pLlpshDcLLuocspFhLGpWlps.A+uhu...........ssstE..................+chYEaNARs.lThW.....uspGslh.DYAs+pWuGLlpsaYh.RWphahstlppslpts..............pshsttpa..thh.phEhtW.sp....sschass.....pstG-slphupp...lhp+h	.....................pWlppYsppRY......Gs...ts....tphtpAWplLhpolYssst.ttttps.......cslhstRPs.hs............................................tpsp.h.h.Ysssc.lhcAhclh.lpsss....phpss...ssacaDLlDlsRQsLu.phspthhpphh...puappp...............c......h..p.............t.h..ptt..upphl.cLl.shDplLuopppFhLGpWlpp.ARshu............s.stp-.........................cc..hYEhNARs.lThW........usp..G...s.lp..DYAs......+pWuGLl.......p.....cYYh.RW.phahstltpslpt.s..........................t.hsttp.a...thh.th.EptW..sp....sp.phass......psts.sslphupp.lh.....................................	0	58	102	140
+12814	PF12973	Cupin_7		ChrR Cupin-like domain	Bateman A	agb	JCSG target 403193	Domain	Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.93	0.72	-4.14	88	1076	2012-10-10 13:59:34	2010-05-23 15:59:43	2	8	611	11	370	1097	835	89.10	27	55.05	CHANGED	sWhsSPhsGVpRt.Lc.Rhu.s.E.u.+sTolVRasPGopFssHsHsGGEEIhVL-GsFsDEp.GcY..PuGoYlRNPsGSpHsPa.S.cpG..CsIhVKLt	................................................hsGlthh.Lp....t.s..t...p.......tssLl+hs.s.G...s...p...h..s...p...H...p...H..tG..sEp.h.h.V.L..cG....s....F.....p....D.c.....p......G.....c....a.........ssG..salh.ps.s.s.s...p.H.s.P.h...s..p..p..G...slhh............................................	0	92	205	288
+12815	PF12974	Phosphonate-bd		ABC transporter, phosphonate, periplasmic substrate-binding protein 	Bateman A	agb	JCSG target 416811	Family	This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.33	0.70	-4.99	178	3450	2012-10-03 15:33:52	2010-05-23 16:08:34	2	64	2087	10	931	7437	1283	236.80	20	68.71	CHANGED	hullPt.p.sssphhpp.....apslhshL...scpl......G.h...p...lchhssssasshhpsht.sGplDluahs.sh..shlh..h..p..pp.s.s..h.pslsph............ht......pG...p...s.........s...................apul..llspp.-.u..s..l...............................p.......sl............................p..DL.......cGcpluhssssSsoGhlhPthhL..............pp...t.G.l...........s.....p...........p.......h........h.p................h.h..a...s....u..sH-ssh.h.uVh.pGpsDuus.................sts............t............sh..pphh...................pps.....h...............ppl+l...........l...........h...........p.o.s...h.Pst.......s.lss.p.ss....ls....sp....h....ppplppsllshs..p.s................................sps.pphlpsh....s...h.....s...uFhsss.spsY	............................................................................................................................................................................hhs.p..s.tp.h.tp.....hp.s.hhph..l....p.cpl...........G..h......p....lp.h..h.h....s..s.s..a....s...s.h......h...p.u..ht...ts.p....l.D....l..u......h..h...s......s...h....s.h.s..........s....t......pp...s...s.......s...ps.l...spt............................ht........ts.....p.....s.............s..................................................a..p...S...h......l..l...sp.p....-....S....s...l......................................p............sl............................p...DL.........+G.+...p...h..u..h...s.s...s.s.Ssu...G..a..lh.Pt.h.h..L.........................................t.c...t..G...l........................s....sp.................................................p.........................h..p........................................................t.s...h..........s....u...u.....H......-.......s....s.l..h.s.lh.s.Gp........s........D.......s..us...........................................ss.s...........................................s....s.h..pp.ht...........................................................pp.t....h...................pcl.+.l...........l................................................h.................................p..o.....s.......h.....h.....P.s.........................s...h.s.s...p...ts.......l..s.............tp........h........tp..plpp..sh.hshst..s.......................................pt.tth.h.p.h.....t...h......t...th...p..........................................................................................................................................................................................................	0	290	614	788
+12816	PF12975	DUF3859		Domain of unknown function (DUF3859)	Bateman A	agb	JCSG target 416836	Domain	This short domain is functionally uncharacterised.	21.00	21.00	21.00	21.80	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.61	0.71	-4.46	33	110	2010-05-23 15:32:20	2010-05-23 16:32:20	2	7	98	2	33	109	13	130.10	29	51.56	CHANGED	hsthpshlshhpaGIasphsscspphsp..................hpptTphVPAclslpFGhhh.slpcucspp...............lphplhHPtI...hsspGpshpsasuplaspss-hshahh-ph..acsls......GpWph.plthcscllA-KoFpV	............................h.p.hlshhpaGlasphspc.p.h.p..................hhp.TspVPAclshcFGhhh..slp+s.cGpp..................lphhhhHPsl.....spcGphhpsapsplhssssDhthYhhsp...a-sls........GcWRh.tlhhs.scllA-KoFpV...	0	5	14	24
+12817	PF12976	DUF3860		Domain of Unknown Function with PDB structure (DUF3860)	Ellrott K	kellrott	JCSG structure PDB:2OD5	Family	A protein family created to cover PDB:2OD5. 2OD5 is a hypothetical protein (JCVI_PEP_1096688149193) from an environmental metagenome (unidentified marine microbe).	27.00	27.00	32.50	138.50	21.90	19.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.98	0.72	-4.19	2	2	2010-05-25 22:37:37	2010-05-25 23:37:37	2	1	1	0	0	5	106	88.00	26	100.00	CHANGED	McoppLRphI+paLsER..tNThEI.talsppMc.sosPpplsNlLptDcsIl+luTs++uGhh.sch.Is.Ws....lR....sta.-tcp.	McoppLRphI+paLsER..tNThEI.talsppMc.sosPpplsNlLptDcsIl+luTs++uGhh.sch.Is.Ws....lR....sta.-tcp.	0	0	0	0
+12818	PF12977	DUF3861		Domain of Unknown Function with PDB structure (DUF3861)	Ellrott K	kellrott	JCSG structure PDB:3CJL	Family	The 3cjl structure is likely a representative of a new fold with some resemblance to 3-helical bundle folds such as the serum albumin-like fold of SCOP. No significant hits reported by a Dali search. This protein is the first structural representative of a small (about 60 proteins) family of proteins that are found among proteo- and enterobacteria (REF http://www.topsan.org/Proteins/JCSG/3CJL).	27.00	27.00	30.10	30.40	24.00	20.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.99	0.72	-3.88	13	132	2010-05-27 00:12:12	2010-05-27 01:12:12	2	1	130	2	37	96	3	95.10	40	92.80	CHANGED	pppYRITlEpLsstpspstc...sLpFEhpsHDDlFsIVE+lKp+psh-..sppuspFuVGLKLhGEVMhpsRKHPLFt-FtPpFtsFMpsLKsts........p	............a+YRITlp.LpctcGcshsps.slpFEspNHDDIhpIlE+Lcs+csls..p-posuFuVGLKLFoElMhcsRc..HP..LFpshtstFppFMppLKpts.sp......	0	6	20	28
+12819	PF12978	DUF3862		Domain of Unknown Function with PDB structure (DUF3862)	Ellrott K	kellrott	JCSG structure PDB:3D4E	Family	PDB:3D4E shared structural similarity to beta-lactamase inhibitory proteins (BLIP) which already include 1XXM, 1S0W, 1JTG, 2G2U, 2G2W, 2B5R, and 3due. All of structures are involved in beta-lactamase inhibitor complex.  (REF http://www.topsan.org/Proteins/JCSG/3d4e)	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.76	0.71	-4.59	9	255	2012-10-01 23:09:26	2010-05-27 22:46:43	2	2	218	1	31	175	0	130.40	26	74.29	CHANGED	ppp-lRtpF-KIKlushpspFcGGoSl--LcplFG.cPspppppsAGsVpLcsYTWshDsVolslp.LhpNSolsKoIoNFpFs.RD.ploLK-YsslpcGhoYc-VschLGEPDshSpAsSS-cpplQAlWlSGlKuc.spuusloLsFENstLosKoQssL	.....................................................t........................p..usp.tplhthhG.p.tpp..........t..........W............s.t........s.....h.h..h.pst..s.....h.pt..s..h...t......+ptp..lshp.passl.........ppGh.oY..ccVpchlG.-P.-..s.h..spssh...s..s.ppphph.lahpshpus....sushsloF.pssplpsKsQ.sL.............................	0	10	20	27
+12820	PF12979	DUF3863		Domain of Unknown Function with PDB structure (DUF3863)	Ellrott K	kellrott	JCSG structure PDB:3LM3	Domain	Domain based on 1-364 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.	27.00	27.00	27.80	198.70	26.60	25.10	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.12	0.70	-5.85	3	9	2010-05-27 23:42:17	2010-05-28 00:42:17	2	2	9	1	4	10	0	350.70	77	74.19	CHANGED	oslTL-GNRFVTLCIMIRTTPWEVSRDVKLHPRDEsSWHTLEGVRALREAFAKNNP-GRLTWGFTLNALEDpR-NY+QIR-YVVECQKKYGDEVSYFPGYFPAMYLPRERVNREMSEAIQLISKMVGNGYRPQSIMGGFLSADNLRYLAEKENIHVAHAVIWSQHNIDGGGADGSPSYPFYPSTEHFCKPAQGKSDFIDCVNLDGWTMDFICARRSGAMGHGIEGYNSRRGVGPIETYTGWGLDLGpREVMHTQAIHFDKGlELNGFGWVTNIWEAQMVHEFGQEFICKAMETWVTETKERWPDT+FVTFGEFGMLWRcpHKoN-DWNYRFVERGSGLGDSYNNLEIKWFMN	..EsLTl-GNRFVTLCIMIRTTPWEVSRDVKLHPRDEssWHTLEGVRALREAFAoNNPNGRLTWGFThNALEDGRcNYR-IRDYVVECQKKYGDEVTYFPG.YFPAMYLPRERVNREMSEAI-IISKMVGNGYRP.QSIMGGFLSADNLRYLAEKENIHVAHAVIWSQHNIDGGGADGSPSYPFYPSTEHFCKPAQGKSDFIDCVNLDGWTMDFICARRSGtoGHGI-GYNSRRGVGPIETY+GWGLDLGHREVMHTpAIHF.DKGlELNGFGWVsNIWEAQMV.HEFGKD.LICDAMchWVTGTKERWPDTHFVTFGEFG-LWRcQaKoN-DWNYRFVERGSGLGDSYNNLEIKWFMN.	0	1	4	4
+12821	PF12980	DUF3864		Domain of Unknown Function with PDB structure (DUF3864)	Ellrott K	kellrott	JCSG structure PDB:3LM3	Domain	Domain based on 366-449 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.	27.00	27.00	106.30	105.40	25.20	24.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.62	0.72	-3.78	3	8	2010-05-27 23:42:58	2010-05-28 00:42:58	2	1	8	1	3	9	0	81.60	80	17.10	CHANGED	RLALLRDWHpKNAPAYVIDFTRYDLKA+EPADPSPcKPAKDWSLINVINQKGLRPQDKPVLLscL-sEcQ-LIRKYYPELFK	RLALLRDWHTKNSPAYVIDFTRYDL.AHEPADPSPpKPAKDWSLINKINQKGLRPQDKPVLIDKLEKEDQDLIRKYYPELFK.	0	1	3	3
+12822	PF12981	DUF3865		Domain of Unknown Function with PDB structure (DUF3865)	Ellrott K	kellrott	JCSG structure PDB:3B5P	Family	Family based of PDB:3B5P encoded by ZP_00108531 from nitrogen-fixing cyanobacterium Nostoc punctiforme pcc 73102 is a CADD-like protein of unknown function. Superposition between protein structures encoded by CT610 from Chlamydia trachomatis (PDB code 1rwc), pyrroloquinolinquinone synthase C (PqqC, PDB code 1otv) and ZP_00108531 revealed that putative active sites in CT610 and ZP_00108531 are identical. ( REF: http://www.topsan.org/Proteins/JCSG/3B5P).	31.60	30.90	31.60	30.90	28.60	27.20	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.70	0.70	-4.57	3	20	2012-10-02 21:56:19	2010-05-28 01:00:09	2	2	12	2	4	21	2	140.20	31	89.32	CHANGED	hK+lScpLsphLspDaluFSlNNNPll..SpISstSFuQhh.VhpQYSlFPKplluhh.hAthph.htsWsGVuEELLpNlNEEMGushGtIo.....HYTlLR+uLc-ulGlsVsNshPSVATppFlcoVcuLl-+ps.-hVLGusYAlEooAIPELhLl+ELV...tEuApcKcLsappohl.pFF-hHLD-lElEH+DcLtshluuYIpsEE.......QatEFt-GFpAsIDsM-sWWo-LspEth	......................................................................................................................................s.lstEl.tNh....EE.s.....................Hh.hhtpuh.p..h...t....hs...lpshh..P...uTpthh.pl.tlh.hps..phshGshYAhEstul.Eh.lhhcls...tchs..ct..ht........F.aphHl.DthE.tHpstL......tp.hsthlt.tp.............hhtGhhshlshhpsaWptL.....s...	0	2	2	4
+12823	PF12982	DUF3866		Protein of unknown function (DUF3866)	Bateman A	agb	Jackhmmer:Q18B83	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 352 and 374 amino acids in length.	25.00	25.00	112.90	28.00	22.90	22.40	hmmbuild  --amino -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.92	0.70	-5.46	30	119	2010-05-28 08:24:37	2010-05-28 09:24:37	2	3	117	0	62	121	2	317.00	43	87.68	CHANGED	tRAlsYspLsGpscsGDcVlLNsTAlthsLGTGGYcaVlus.sphs.s........ssGHIMKhRYTPhQhpVLusEEpcSPaHchhpssc.oLcGhPVlVu-LHShLsPlssul..+pts.....Ps...........hRluYlMTDGGALPltaSpsVtpL+cpGhlsuTlTsGpAFGGDhEAlNlaouLlAA+pllcADlllVu.GPGllGTGT+aGFSGlptGchlsAlssLGG+PlulsRlShADsRtRHpGlSHHolTslsclsLsssplslPhh.tt-.............ttshlpcQlpsh...sp+Hp....ll..hl.sssthtpsLpphslploTMGRuhp-DssaFlAsuAAuh	.......................+AlsYsplsGpspsGDcVlLNsTAlthsLGTGGYshVl..us.sths....-ss...................ssGH.lhKhRYTPhQhtVLus-EppSPaHshhpp.sc...sLcGhPVlVu-LHShLssls.uul.+........p...t.s.....Ps...........h+lsYlMTDGGALPlhaS+sVttL+cpGhlsu.TlTsGpAFGGDhEuVslaouLluA+cVlcADlslVu.GPG.lGTGT+aGFSGlptuchlsAlstLGG+Pluh.RlShuDtRpRHpGlSHHolTshsclshsssslsl.Ph.h.ss-...................htthlppQlpt.......tp+....H.p..ll..hl...ss....sth....tp...h...L....c....p....h....s.lploTMGRuh-pDssaFlAAuAAu.h..................	0	36	54	59
+12824	PF12983	DUF3867		Protein of unknown function (DUF3867)	Bateman A	agb	Jackhmmer:Q18BR7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.	27.00	27.00	131.90	131.60	22.60	22.60	hmmbuild  --amino -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.29	0.71	-4.31	10	47	2010-05-28 12:03:52	2010-05-28 13:03:52	2	1	46	0	9	31	0	187.50	55	98.74	CHANGED	D+IIDFNELKNKVKDKDlDKFEsYIYSLYYclApGKLoMuDFS+cIhcYMEENNISQEKFhNIQKKhhER....YGhDsu-IEcQhKshGlDssshu...psssY...........................Esl+KohuFQEKYKs+IpsKosopYaIKN-KNDlclllEpEcVlLpSsKKIDLsDsELNEFLCSYKKllcDKKLcIslCEslKpY-Y	.D+IIDFNELKNKA+DKDlDKFEpYlYsLYaSV.spGphoMu-FS+cIhcYMc-NNISQEKFlNIQKchhER....YGhD.....hp-lEcQhKshG..lDhsslG...psssY...........................Esl+Ks..lSFpEKYpuKlpsKslopYaIKN-KNDlclll-sEclhLpSsKKIDL.pDoELNEFLCSYKKhhpsKpLpIslCEslspYsY.....	0	5	9	9
+12825	PF12984	DUF3868		Domain of unknown function, B. Theta Gene description (DUF3868)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_1065	Family	Based on Bacteroides thetaiotaomicron gene BT_1065, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.40	27.30	26.60	26.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.45	0.71	-4.57	11	235	2010-06-17 22:02:38	2010-06-17 23:02:38	2	7	74	0	30	212	2	109.50	21	24.44	CHANGED	+phhhlhhhLhlhsh...sh.AQst...apGtlslssspLcQcG-olhlshslslpslplcSppulslsPhLhS....uspphpLPplllpG+pchKsYcRplAltstpccspath......llht	........................................h.....hhh.h.lhhhsh.......sstAQph.....tstlplssh.p.l.pp..pGc.p..lhlshslsl.s.s.l.plsoscslhLoPlLts.........uscpht..LPslhlsG+p.+.phh..p..Rphuh..ptp................th.h......................	0	7	25	30
+12826	PF12985	DUF3869		Domain of unknown function (DUF3869)	Ellrott K, Bakolitsa C	kellrott	JCSG structure PDB:3KOG	Family	A family based on the N-terminal domain of 3KOG, which shows weak but consistent remote homology with adhesive families such as immunoglobulins and cadherins, suggesting it might form an attachment module.	20.40	20.40	22.30	28.10	20.20	18.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.42	0.72	-3.60	10	29	2010-06-17 22:50:21	2010-06-17 23:50:21	2	2	22	2	4	27	2	110.80	32	32.71	CHANGED	shFTSC.EKEEFNVs.lcsssApATIusTVhDhsoG..sslT............oussTluuuu.....ssplAupotshsA..ostsYho.uospVplPALscGQaAslsVoIhLQchtuAscsss	..shFTSC.EKEE....h..sl.....s..spsssAphhIssoVhDssTG..pslo............oApsTlusuuh........hssplA.tpu.h...slss...ssssYhs.sstsVplstlpsGQhushsVslhLpp.tsst..s..........	0	0	3	4
+12827	PF12986	DUF3870		Domain of unknown function (DUF3870)	Ellrott K, Bakolitsa C	kellrott	JCSG structure PDB:3KOG	Family	A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins [1][2], suggesting it may have a lytic function. 	22.00	22.00	23.00	28.10	21.10	17.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.17	0.72	-3.74	19	200	2010-06-17 22:53:45	2010-06-17 23:53:45	2	2	158	1	42	130	0	94.70	40	81.03	CHANGED	lYIlG-A+os.sNsITcpYphFFIuFllcccsscIl..Dh-souTlpLTpsFl+plFlG+shhc.p-tlhp.ElcpRYaGSSQKAllVAY+cAhpKYpp	................YlsGcAKsPpsNsITchacoaaluhlls+cTGcIl..DA-CosoltLTppFV+pLFls+slpD..stLlt.ElcsRYFGSSQKALlsAlKDAp++Yp....	1	18	33	35
+12828	PF12987	DUF3871		Domain of unknown function, B. Theta Gene description (DUF3871)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2984	Family	Based on Bacteroides thetaiotaomicron gene BT_2984, a putative uncharacterized protein  As seen in gene expression experiments  (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	34.00	33.90	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.83	0.70	-5.73	13	110	2010-06-17 23:00:13	2010-06-18 00:00:13	2	1	53	0	17	109	3	294.40	52	93.83	CHANGED	opNhG.EaAEEAsII..psspspcpspFIEANTpElTLpHLKNDCIlPVFAKDNElTISHpsFIEsVa-AAsoFFuGEpIspP-IRVSHlIKGRIPEAIpKsAspLLEuDKThYYERhAFsI-IPTIYETVsGN+LsLoIGGVRAYNchNLY.SKKusE+FKlFIGF+spVCoNhCloTDGYpsslEVoNopELYpulLELFpsYNPAKH..lHLMQoLusThloE+QFsQlLGRMRLYQsLPpuhQKplP+hLlTDoQINsVAKAYlsD-NFGuh..Gs-lSMWchYNLLTGANKSSYIDSFLDRulNATElusGIssAL.+G.D-+..YpWFl	...........................p.hE-AsIl..ps.t...ppps.FIEANTpElTlpaLcp-CIlPVFuKDNEhTISH.sFI-sV.-AApsaFsGEplppP-IRVSHlIKGRlPpAlpK.sspLLEsDKTIYYERhAFshcIPTIhEslpGN+LsLoIGGVRAYNc.NLY.SKKus.E+FKlFIGFpspVCsNhCl.oTDGapsplcVhssp-LYpusL-LFppYNsAKc..l+LMpsLuso.hoEpQFsQllGRhRLYQsLP.u.pKp..lP+hLlTDoQINsVA+uYhsDcNFush..ssslSMWchYNLLTGANKS.SYIDoFL-RulNATElusGIspAL.pG.Ds.c..YpWFl.......	0	4	16	17
+12829	PF12988	DUF3872		Domain of unknown function, B. Theta Gene description (DUF3872)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2593	Family	Based on Bacteroides thetaiotaomicron gene BT_2593, a conserved protein found in a conjugate transposon. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	29.40	32.30	26.30	23.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.61	0.71	-4.63	21	300	2010-06-17 23:03:44	2010-06-18 00:03:44	2	1	109	2	24	255	3	133.40	51	87.93	CHANGED	hlsplhshss.lshuhlsloAC..sc-LDlQQsYPFoVETMPVsKcIspGETsEIRCpLpR-GcFssTpYTIRYFQPDGcGpL+h-cGTVhhPNDRYPLscEpFRLYYTStS.s-pQoIDlYlEDsa..GphpQloFsFNNcs	........l...phhsh.sh.lshsshsLsuC..-c-.LDlQQuYPFoVEoMPV.cclspGpTsEIRCpLKRpGcFssTtYTIRYFQ.DGcGpL......+h.DsGhsFhPN...........DRY.Lp...........c...........-.pFRLYYTStS.s-pQslcVaVEDNF..GphhpLsFsFNNc.......	0	7	20	24
+12830	PF12989	DUF3873		Domain of unknown function, B. Theta Gene description (DUF3873)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2286	Family	Based on Bacteroides thetaiotaomicron gene BT_2286, a putative uncharacterized protein.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.60	27.30	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.39	0.72	-3.85	9	114	2010-06-17 23:08:19	2010-06-18 00:08:19	2	2	63	0	6	83	0	67.20	61	90.38	CHANGED	tsphshNGVSlCpssGcEKYpKaphslt.t+tpphYQYDYRcs.ssELFSCVusTL-ECRcpRDcWLppKp	.....ppMTlNGVSTCppuGpEKYE+FQ.GlG.RR+RThlQYDYRHs.DGELFSCVKPTLDECRptRDcWLstKp.........	0	3	5	6
+12831	PF12990	DUF3874		Domain of unknonw function from B. Theta Gene description (DUF3874)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4228	Family	Based on Bacteroides thetaiotaomicron gene BT_4228, a putative uncharacterized protein  As seen in gene expression experiments  (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.00	27.20	25.90	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.35	0.72	-3.86	12	222	2010-06-17 23:12:49	2010-06-18 00:12:49	2	4	61	0	19	204	0	72.40	34	14.28	CHANGED	Y+hss.EEVhtsCFR..hstt.sEcsh.LSAusIFphLpctpPAAMRGssshphuplLhuhGlcRpHTcaGNVYpV	........hsshEplFhphFR..sApp...tE-uchLoss-IhphLp+pssh.s.hps.s.plspFGRlLpph.Glpp+HTppGslYpV..........	0	9	18	19
+12832	PF12991	DUF3875		Domain of unknown function, B. Theta Gene description (DUF3875)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4769	Family	Based on Bacteroides thetaiotaomicron gene BT_4769, a conserved protein found in a conjugate transposon. As seem in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.50	27.20	25.40	26.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.69	0.72	-4.28	17	294	2010-06-17 23:17:18	2010-06-18 00:17:18	2	4	123	0	37	265	8	53.20	67	7.11	CHANGED	RNlhKssTLESKFPLLAVEpsCIlSKDADlTVuFcV-LPELFTVTuuEYEAhHS	...........RNh.KhoTLEsKFPLLuV..E.p..GCIlSKDADITVAFcVELPELFTVTuuEYEAIHu...	0	13	32	37
+12833	PF12992	DUF3876		Domain of unknown function, B. Theta Gene description (DUF3876)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0092	Family	Based on Bacteroides thetaiotaomicron gene BT_0092, a conserved protein found in a conjugate transposon. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	28.00	28.00	25.40	24.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.09	0.72	-4.05	19	215	2010-06-17 23:20:33	2010-06-18 00:20:33	2	1	93	0	21	156	1	93.10	42	80.70	CHANGED	hpsspp..shchcplsGsWcSlst+PsVhla+-ucpYplolhthsthstphpPpTY.l.p.ccsGshFIsTGa.Rl.lsYcptpDlLohSstG...-YlRs	...........h..oCp..sspch-tlsGsWcSVp.G.+.PsV.hIY+-....Gcs....Y+VTlhp+SshpRph+PcTY.l.p..E-sGsLFhsTGa.RlsluYscusDlLohSPsG...DYlR.....................	0	6	14	19
+12834	PF12993	DUF3877		Domain of unknown function, E. rectale Gene description (DUF3877)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_0237	Family	Based on Eubacterium rectale gene EUBREC_0237.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	129.70	129.40	26.10	25.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.23	0.71	-4.71	14	33	2010-06-18 21:49:19	2010-06-18 22:49:19	2	2	33	0	4	31	2	175.20	45	90.95	CHANGED	acRLE+sLIDlIKEEQAKLGYRKEpIRLYYPLSSLNHFFpscsss-cMpctLpp............Fschhcp+LGclpVopKs-RFCFpIPEpGu-YVHEphptNEFI+-LIELlu+HGCTh--IhsLF+paS-plhhEcMsNGEFDhhIpFpp-s-DsYYYCFKDEGCHIIYHRFLPEDYsDFGF	..ap+LE+slIDlIKEEQhKLGYc+EsIRLYYPloSLN+Fhps..-s..s.tccMpptLpp............FscphpppLG-lclo.pKs-RFChpIPtcGupYVHEpsscsEFIK-Llplluc.HGCThE-lhclFc....pYS-.plhh....EchpsG.EFDhllpFp-ss.DsYYYCh+DEGCHlIYHRFLPEDYtDFsF...	0	3	4	4
+12835	PF12994	DUF3878		Domain of unknown function, E. rectale Gene description (DUF3878)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_0973	Family	Based on Eubacterium rectale gene EUBREC_0973. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737). it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	63.70	63.50	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.05	0.70	-5.24	3	29	2010-06-18 22:00:08	2010-06-18 23:00:08	2	1	28	0	2	27	1	283.00	34	86.14	CHANGED	pISRAFphLAElFEYQVFELCVuE-....pYlIPYMMNDAVECYLol+GsploGcYp+D-ElEsuupLttcEcRYGLIVHQGEENVFTLWFDELcEHpsCF+YHEIGHFWV-GQEQWRQLVYMIGTItEKYpYLGEEYCNEsEptIMSLIEFAPFRhWoPVsEDLEEa.YPAThEGIDCMEcLARcAuD+DYLKWIc+YR+aPo++hE+LLuR+LtDPKRQcLYEhICccVpsAS-sYPpRNYGEcINpRIQ+KRcpl-KKLLEcGFTGpYPpYpKKphoVsVTEEHPFTluhLEaEDFKFKlQ	................................sh.hLtplh-.p.FE.lh...h.s-p................phhls..YhMNDAVEsaLsFc..su+hoGpYpp..-h........E...sthtApl...ptp......-s..tYsLlV+Q......t-.sVh.T...laFcclp.chphYpYtcIGHFWVcGhE.hRpL.YhluhlpDKacYLGcchCs-pEtcLhpLh-FsPhp..h..YssVsEp.........c-.....asso..t..EulshMpclAtcssDcshl+hLchYc+pPs+hhp+hluthLpcs++tplhchlhcclppAopsYspRsaG...pp...hc...p+hp...c...h...tcphcp...cLhc...pGhpsh....................................................................	0	1	2	2
+12836	PF12995	DUF3879		Domain of unknown function, E. rectale Gene description (DUF3879)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_1343	Family	Based on Eubacterium rectale gene EUBREC_1343.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	27.90	32.60	25.00	26.70	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.20	0.71	-4.70	3	33	2010-06-18 22:08:48	2010-06-18 23:08:48	2	1	13	0	7	33	6	165.70	48	87.36	CHANGED	plNSSSVQcQLKAAGIDTNSKQYKAAlSEMM+sGNGAMYTNIQAIKNLMS+YDKDGDWINPsTGLAGLLVTDENcNS+KRIISIPESS+EEMFELTKKEFLpENGVpNGDTTKRo-VYNNLYRKM-KcDRLAAGYTLEcYERQYRQAFsDAAKsADPsWEAGKPIhAGALDcITRESAEoG.........RKSs-	................................sGIsTNSKpYKA.........s.........l..pp...........MMpstpthhapsh...tu.....IKNLMpQaDpsGDhlss.sGlsGhsVTscs.sSap+IlSlsEs.+pcMF-.sK+EFlpENGh.NGDTTKRpslapsh.hphsK-cRLuAGWTLEQYEtQYRpAhhtAsKsAsPsW+sGpshssuhLDslTRESsEus.......................	0	4	7	7
+12837	PF12996	DUF3880		DUF based on E. rectale Gene description (DUF3880)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_3218	Family	Based on Eubacterium rectale gene EUBREC_3218.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737),  It appears to be upregulated in the presence of  Bacteroides thetaiotaomicron vs when isolated in culture [1].	21.70	21.70	21.70	21.80	21.20	21.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.75	0.72	-4.07	48	247	2010-06-18 22:21:15	2010-06-18 23:21:15	2	10	156	0	76	245	24	76.70	27	17.81	CHANGED	WhsDsPhhtlas.h.sl.hsshN.hIFhFDpsphppa+shGhpplaaLPLAssssRhs.hhtp..................t.ppapsDlSFVGs..hYpp	...............................WhsDsPhah..hs...h.....pl..hs..hs.hlFThDt.s.slpha+.s.h.GhppVa.aLP.LAsssph.apPhhtp.....................ppaps-lsFlGssa....................	1	35	64	67
+12838	PF12997	DUF3881		Domain of unknown function, E. rectale Gene description (DUF3881)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_3695	Family	Based on Eubacterium rectale gene EUBREC_3695.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	106.10	105.20	21.80	20.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.72	0.70	-5.40	28	81	2010-06-18 22:31:02	2010-06-18 23:31:02	2	2	75	0	8	77	13	258.60	41	95.97	CHANGED	LRAIGFSslpp+c-lcclLcplhcphsppphl..p.pcspcasEhp+-ausshGIsVpG-hDc.....sspFch-YYaPYapGssloopt-lslE++s-+EuYsGlCDDh+lGloLIFYLQNsh-Yhcp+....................thsphshphpulsLSGLuspGpILLPlpKscpppcp....pcppscs.RppLlsAA+sGDpsAIEoLTl-DIDhYStlSRRlhsEDlaSIVDThFMPaGlECDpYSllGEIl-lcpppNphTsEplY.hcL-CN-lpFclCINcpDLlGEPtVGRRFKGpIWLQG	............L+ulGFuplpp+p-lcclLcpl..c.p.hsp.pphl..p.pc....tpphsEhpp-h........usshGIslhG..ch-c.....pspFph-YYaPYhpusslooht-sslE++h-+EsYsGls-Dh+lGloLIFaLpNshEYhppc.....................htt..hpspulsLoGLuhpGpILLPlpKsppphcp....p.pptscsRppLlpAA+sGDpsAhEoLTl-DhDhYSplS+Rlh..pEDlaSIV-ohFMPhGlECDpYSllGEIhplcpppNthTtEplY.hplcsN-l.FcVsIscpDLhGEPtlGRRFKGplWhQG................	0	6	8	8
+12839	PF12998	ING		Inhibitor of growth proteins N-terminal histone-binding	Wood V, Coggill P	pcc	Pfam-B_205 (release 24.0)	Domain	Histones undergo numerous post-translational modifications, including acetylation and methylation, at residues which are then probable docking sites for various chromatin remodelling complexes. Inhibitor of growth proteins (INGs) specifically bind to residues that have been thus modified. INGs carry a well-characterised C-terminal PHD-type zinc-finger domain, binding with lysine 4-tri-methylated histone H3 (H3K4me3), as well as this N-terminal domain that binds unmodified H3 tails. Although these two regions can bind histones independently, together they increase the apparent association of the ING for the H3 tail.	23.70	23.70	23.80	23.70	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.25	0.72	-3.76	79	827	2010-06-28 12:29:44	2010-06-28 13:29:44	2	12	279	6	538	851	2	102.20	26	28.97	CHANGED	shL-cal-sl-sLPtElp+hhs.l+-lDtp...hppthppl-pphccalppstt..............................ht.p....pcpphhppIpcphpcsppht-EKlplusphh-ll-++h++LDtchcph	.......................................................hl-cal-s.....l-sLPh-lp+phs.h+-lDtp..........hpshhp.p.l...-phhpca..hppspp...................................................................................t.p...pcpphhppIppshtcstchuDEKlp.lupphh-l.l-++l++LDtclth.................................................	0	154	245	401
+12840	PF12999	PRKCSH-like		Glucosidase II beta subunit-like	Coggill P	pcc	Wood V	Family	The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1].	26.30	26.30	28.10	27.00	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.49	0.71	-4.69	5	445	2010-06-28 12:42:30	2010-06-28 13:42:30	2	22	268	0	317	453	13	145.60	32	32.92	CHANGED	lhlPlLuluLhlusA.lscLRGVuPDcLcLYpPD.ENGN..WKCLNcscIhLSFDQVNDDYCDCPDGSDEPGTuAC.pNG..KFYCsNcGaIPuYIPSF+VDDGVCDYclCCDGSDE..plG+CPN+CsElAcpacchpsE+Nspl+sGLKIKccllltup+KsDElpp+hcELccoLhAcppct	........................................hhhh............................hGl..t..thY.p........t.......a.pC..l.ss..s....th......lshsp..l..ND-aCDC.s.D.GSD.EPGTu.A...C....s...........ps....................tFaCp.....N...t.G..a..hs...h.....h.....lspsp..VNDGlCD...CCDGSDEh.............st....s...t..C......spCtpht.pt..pt..p..t.....p.hp...tu....ht.h.+t..hh....t.....t.h....t....t..............tp.tt.t...............tht........................................................................	0	105	178	269
+12841	PF13000	Acatn		Acetyl-coenzyme A transporter 1	Coggill P	pcc	Wood V	Family	The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.	102.60	99.30	109.50	100.10	102.50	99.20	hmmbuild  -o /dev/null HMM SEED	544	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.79	0.70	-5.99	2	464	2012-10-03 03:33:39	2010-06-28 15:33:01	2	7	252	0	348	478	3	242.70	26	72.83	CHANGED	phYhLIhLYLhQGlPhGLshGolPahLKs...psSaosLuhaShAsYPYSLKllWSPIVDohYs+phGRR+oWllPs.hl.u.sLhhhuasl..........Dsahs+GsuhlpSho....TW.F.LLVFlCATQDIAVDGWuLshLs.EpLSYASTAQTlGLNhGaFhSFTIhLshsSs-FANpahRsIP.scGhIoLuGYhKF.uhhhhlholhlhF..............................aD-us...pQphusIp.ha+shhtsLpLKshRpLhhlHhluKhuF.sNEshT.LKhhE.GhppE.LulhlLIshPhtlhhGhYss+hSs.+s............................Ls.WLhGahGRlsuhlLsohlV.......+pFP........hFh.lhhpahLsu.hsTlQFlulusFHo+luDPhlGGTYMTlLNTLSNhGGoWPphlhhpMhshhTV.pC.ThP...+lhsotsuphptC.phLsGTshhhRDGYYlTsllsIhlul.lhhuhlp.hlh+LpphPISSW+h........T	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p...............................................................	0	113	181	282
+12842	PF13001	Ecm29		Proteasome stabiliser	Wood V, Coggill P	pcc	Pfam-B_682 (release 24.0)	Family	The proteasome consists of two subunits, and the capacity of the proteasome to degrade protein depends crucially on the interaction between these two subunits. This interaction is affected by a wide range of factors including metabolites, such as ATP, and proteasome-associated proteins such as Ecm29. Ecm29 stabilises the interaction between the two subunits.	20.50	20.50	21.00	21.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	501	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.69	0.70	-6.01	45	308	2010-06-28 15:32:17	2010-06-28 16:32:17	2	15	231	0	217	302	1	426.60	25	27.72	CHANGED	ls+V-LRl.ALA-sDccLcphLspaLsPlLLKLuSspsuVRpKVlcllpH.lNpRlp.u.tsIpLPVssLLcQacpss.....ssshV+pFsllYlppGl-RL.sssc+hpllPpllpGI...........S......ptshsptuhhFtllh.+lL..h+h..P.cssp-ppphcsp..htl.t-...p.sthLh.hhsph.hh.......t..................................ss.sssulssppsshhoh.t.....stsssh.s..pLpcsKhslLcFLsuuhh...............................s-tphhlshLlASuD............ss.ppluchu-phLK+hpss........hEsspllppLapLah...........................s.t.tptt.PspssLph+ILshLsKShtAssphspshplhptuLhos.h..ss+lcshshphh.................................spshpphssphlptlpshlhspshshh.......spsp.t......tpshplRshsYcslGhLsp+tsphh.c-......hsllpaLFcuL..cspss-ltsuIpcALuulhsuhsp..p.............................t.thphhh.lh.ttpp...........p.ttssRasAl+aANpsaPasDssuRalsllu	......................lp+l.hRl.uhA-sD.ppLpphlppaLsPll....L....KLuS.s.pt.uVRp..............K.........V...............h...pllt...H.lspRlp.s.splpLPltsLl.Qappss................sshl.ppFsl.lal..phuhsRl.sspcphplhPtllpsh............................p......p.t.hhphhh.h..hhh...+h............p....s.p..p.t....pp.pph.....hl.s....h.phhLh.hh.hh...............................................................tsth......t...shhoh............st..ssh.h....p..pL.pphK....lsllpFl.tut.h...................................................s-.phhh.hlhAu.uD............sp.pp...l.ushu-..L..K+hts.....................hp..s.sllppLaplah..............................................s...t.th.Pspstlph+llshL.+.Sh.Asp....th..st.hpll.t..slh...us.........pt.+hcthshphh................................................h...ths..hlp..ltshlhsthh.hh......................tps.phhshuYpslGhL.upphsp.h...h.ppc..............hsllt.LFpuL.........ppp.tsphthuI.ppALsthhsshtt..t........................................t..hhh.h..lh.t.............................................................................p..htsR.sul+auspshs.pch.uRal.llu..............................................................................................................................................................................................................	0	63	112	179
+12843	PF13002	LDB19		Arrestin_N terminal like	Coggill P	pcc	/wood V	Family	This is a family of proteins related to the Arrestin_N terminal family.	21.60	21.60	21.90	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.25	0.71	-4.80	5	121	2012-10-02 22:29:00	2010-06-28 16:40:07	2	3	103	0	96	133	0	181.80	37	30.53	CHANGED	VpLsLlQKVHFHKPFhsshpuIQTCpNCpoKTTcl+SWDIQsNTs-LsVGoasaPFSaLIPGSlPAoooLGusuETplKYELpAsVsYhD............PctthSs.uKcplLpLsMPIsVTRSlhRGPDKNSLRVFPPTELTAsAVLPNVVYPKSoFPLEMKl-GlSpGD....RRWRMRKLoWRIEEpTRI+uHAC-pHKH-L	...................................hphhtplphpKP..............s..........hpsCtsCpsphs-LppWph....L.spst..s.LppG.p.HsaPFSaLlPGpLPuSss.......s.s.l..sp..lpYcLpAp.uph.....................ss.up...t..lphphPlslpR..ol.h.t.G.s.D..+..sSlRl....FP..P.T.slsAsssLPsVlaPtu.o.FPlph+LcGl..s....s..ts......pRWRlRKlsWRlEEpt+lhu.ACs+Httc...........................................................................	0	18	48	84
+12844	PF13003	MRL1		Ribosomal protein L1	Coggill P	pcc	manual	Domain	This family includes putative ribosomal L1 and L10 proteins and fragments.	21.90	21.90	23.10	22.40	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.91	0.71	-4.34	7	64	2012-10-01 21:21:48	2010-06-29 16:43:58	2	1	40	0	28	58	2	142.90	51	46.98	CHANGED	M..................................................hs..pshc.st.htscppthsplph..............................................................slYh..............................................................................sslhhsp.hhsphppssVs	...................................hhtt.......................h...hs.RpaAAA.....pKs..sKKsKKss.KcKss-EKp.D-lEKhKsYsaMEuEPEDDVYLKRLYPRpIYEVEKAlcLLKKFQhLDFTsPKQ..............sVYLDLTL.DMsLt....K.K...KKVEPFs............................................................SslpLPYPFsSElNKVsVF.	0	2	5	11
+12845	PF13004	BACON		Bacteroidetes-Associated Carbohydrate-binding Often N-terminal	Coggill P	pcc	Rigden D	Domain	The BACON (Bacteroidetes-Associated Carbohydrate-binding Often N-terminal) domain is an all-beta domain found in diverse architectures, principally in combination with carbohydrate-active enzymes and proteases. These architectures suggest a carbohydrate-binding function which is also supported by the nature of BACON's few conserved amino-acids. The phyletic distribution of BACON and other data tentatively suggest that it may frequently function to bind mucin.	20.00	13.30	20.00	13.30	19.90	13.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-10.03	0.72	-3.75	432	1404	2010-07-09 08:33:15	2010-07-09 09:33:15	2	119	153	0	197	1347	35	73.70	18	20.89	CHANGED	sls..............ls...............................................ssss...W...l..........sls.tst.....................tts.lsls....lstN...ss.tp...t....Rp.upl...pl.....................t........tp........ts.......l.sl....p..Qtu	.......................................................................hp...ss..................................spssss.....W........l...........sls.sst...........................tpsplsls..ss.t.N....ss.sp...t..Rs..upl...pl.............pss....shs........tp......l..sl..p..Qt.......................................	0	119	177	197
+12846	PF13005	zf-IS66	HTH_Tnp_IS66;	zinc-finger binding domain of transposase IS66 	Coggill P	pcc	IS-finder	Domain	This is a zinc-finger region of the N-terminus of the insertion element IS66 transposase.	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.54	0.72	-3.99	190	3219	2011-09-20 07:06:31	2010-07-12 16:03:04	2	18	1017	0	565	2843	332	45.40	39	10.71	CHANGED	psptCss..CGs.plp..plGc-.l..sEpL-hlP.uphc.VhcahR.+auCpp..C.c	..................ppsCPs....CGG.pLp...hlG--.s...uEpL-lls..ush+.VI.cphR.KhACsp..C-............	0	111	286	407
+12847	PF13006	Nterm_IS4		Insertion element 4 transposase N-terminal	Coggill P	pcc	IS_finder	Family	This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), Pfam:PF01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain [1].	21.80	21.80	22.00	22.10	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.07	0.72	-3.97	36	1119	2010-07-12 15:15:56	2010-07-12 16:15:56	2	6	317	0	125	971	61	88.10	61	26.57	CHANGED	sshsslusLschlPh-hl-pslptTGpushR+.RcLPuchsVahVluhuLapcps..hp-VhppLshsLss................hphsusSAlspARpRLGscPlctLFcp	.............SL..RNPLTSLGDYLsPELISRCLAESGTVTLRK.RRLPLEMMVWCIVGMALERKEP..LHQIVNRLDIMLPG...............sRPFVAPSAVIQARQRLGuEAVRcVFs.c.....................................	0	19	55	80
+12848	PF13007	LZ_Tnp_IS66		Transposase C of IS166 homeodomain	Coggill P	pcc	IS_finder	Family	This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.91	0.72	-3.32	254	3061	2010-07-12 15:45:03	2010-07-12 16:45:03	2	20	942	0	489	2621	269	73.50	31	17.94	CHANGED	ppLcpplthhcRphFGp+SE+h..s.......tQhpL...h...p..-h-sststht.........sphcptsttsss.............ttt+pc..ss.RpsL.P.scLP.Rtch	.................cLptpltpLpRhhFGppSEKl....sc...............tQhch.........h..p....clptptsphp.....................tp.tc..ts......................t..+pp...ppR+PL.P.tpLP.R-p.p.....................................	0	97	233	341
+12849	PF13008	zf-Paramyx-P		Zinc-binding domain of Paramyxoviridae V protein	Karlin D, Coggill P	pcc	manual	Domain	The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT [1]. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction [3]. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation [2].  The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced.	25.00	25.00	33.20	47.40	21.50	16.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.16	0.72	-4.77	26	152	2010-07-13 14:16:56	2010-07-13 15:16:56	2	5	76	3	0	147	0	46.90	50	16.38	CHANGED	SlsWs..supsplpcWCNPtCuPlsstspptpCsCGpCPphCspCtpDs	......SlsWs..ssclhlpcWCNPhCS.lTsssp+tpCpCGpCPphCcpCcpD...	0	0	0	0
+12850	PF13009	Phage_Integr_2		Putative phage integrase	Coggill P	pcc	Pfam-B_5288 (release 24.0)	Family	This family is found in association with IS elements.	22.80	22.80	76.30	41.10	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.14	0.70	-5.49	22	56	2012-10-02 14:09:14	2010-07-21 11:59:58	1	14	53	0	20	60	8	318.40	30	34.49	CHANGED	PphtpWtphupcalptpsp..uhsp+hpuLspFltpYlh..shPh...sPtsahp........sppph.shlpth...........ssspspphhshlppFlcalLpphho.pD...Dp.Gp.lh.stapNPlsph..shpsh.tt...sETs+ssLPhpaIpph+phLsss..........................papDatWspp..............ssWh.Vs.p..lscsDscClaRshth.p................htplWSPVpshsLashLpLPlRohQlRhLDSGEuDshhY....ppt.spWlhN.ssphA........ppshpcGhh.++hp-st................t.sGLalsTNKTup.............sp.ppGYsIPWt.....pp-lhaWLh+LRpWQpKY.NPIscsTsWp-	.........................................................................................................................phttWtphht-alpsppt..shsp+hpuLstFhppYlhtpshsh...sPttahp............hstpph.phlcpt...........sssptpphhshlpsFlcallpchhoppD...-s.Gphlh.sta+NPls+h.....shps..p.....sEos+ssLPYpYIpchRphLsst..........................pFpDapaApp............ssDWhtVs.p..IDcs..........DPDC..VaRtpps.t................hhplWSPV+hhslashLpLPLRshQlRhLDSGEADshha........pt..spWhhN.psthA........t..ppshppGlh++hpcpt...................sGlalsTNKT...............st.tpGYhIPW........sp-lhYWL.KLRsWQpKY.NPIspPTsWs..............	0	5	9	14
+12851	PF13010	pRN1_helical		Primase helical domain	Bateman A	agb	Jackhmmer:Q54324.1	Domain	This alpha helical domain is found in a set of bacterial plasmid replication proteins [1]. The domain is found to the C-terminus of the primase/polymerase domain. Mutants of this domain are defective in template binding, dinucleotide formation and conformation change prior to DNA extension [1].	27.00	27.00	142.00	142.00	23.10	20.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.86	0.71	-4.54	9	9	2010-07-21 11:16:13	2010-07-21 12:16:13	1	3	5	4	2	12	0	132.40	48	16.02	CHANGED	tG+cEcp-...tc-hEKL+cEhsKYs+a+GKTlEAIRpElCpclK+pl..........ppKhpthhphshpVlC-uKoYu-lGIDRSRGDW+VlphLhoHGVTDlDhlhQLLPpDSKVas.PKWD..KYFlHTLtKAWphVK.aLch	..t.scpEcp-..s-c-hEKL+cEhsKYs+a+GKTlEAIRpElCpclK+pl..........ppKhpthhphshpVlC-uKoYu-lGIDRSRGDW+VlphLhoHGVTDlDhlhQLLPpDSKVas.PKWD..KYFlHTLtKAWphVK.aLch.	0	1	1	2
+12852	PF13011	LZ_Tnp_IS481		leucine-zipper of insertion element IS481	Coggill P	pcc	IS_finder	Family	This is the upstream region of the conjoined ORF AB of insertion element 481. The significance of IS481 in the detection of Bordetella pertussis is discussed in [1]. The B portion of the ORF AB carries the transposase activity in family rve, PFAM:PF00665.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.80	0.72	-3.64	2	445	2012-10-04 14:01:12	2010-07-21 13:08:03	1	5	189	0	209	1294	169	81.90	41	27.81	CHANGED	M.sHtpARLTlhGRsLLVpRVhppphshtpsupthGVShpsua+WlsRFRuEGLcGLhDRSSRP+psP+tsuPEp.cthhptRtQ	........................................M.sHpNAh.LT....htRh...chs..pp..ll..p.p.th.s...lscAAc...taGVS.htT.sp+WhsRaRspGt.s.Gh..s...D..R..S...S........R...P..p.p..o.P.p.p..h.s.s.th.tp.tIlplR..h...................................................	0	121	173	198
+12853	PF13012	MitMem_reg		Maintenance of mitochondrial structure and function	Wood V, Coggill P	pcc	[1]	Family	This is C-terminal to the Mov24 region of the yeast proteasomal subunit Rpn11 and seems likely to regulate the mitochondrial fission and tubulation processes, ie the outer mitochondrial membrane proteins. This function appears to be unrelated to the proteasome activity of the N-terminal region [1].	22.10	22.10	22.20	22.70	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.52	0.71	-4.00	148	1224	2010-07-21 12:18:05	2010-07-21 13:18:05	1	19	336	4	844	1138	8	118.00	23	35.91	CHANGED	pEsEc...........l......ulctLl+............slpcpt........ho.sl....s.p+hptptpuLtsLpp+lhphstYLpsl......ttphshspplhpplpslhsLlP..sh.......................spph...........pcphphpssD..plhlhYluplspsph...slpsllssp	..................................................................Escp....h..........ulptLh+...................slpcpt.........hu..sl....s.p+lptptpuLtsLpp+ltplttYlpcl.................ttph..s.h....s....ppl...hpplpsl..hsL.hP..sh................................spph....................pc.thphpssD.....pLhlhYluplspsph.......slpphlpp...........................................................	0	315	475	695
+12854	PF13013	F-box-like_2		F-box-like domain	Wood V, Coggill P	pcc	Wood V	Family	The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.	21.60	21.60	21.80	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.53	0.72	-4.34	7	39	2012-10-02 00:56:31	2010-07-21 15:07:26	1	2	22	0	34	54	0	97.80	19	19.17	CHANGED	sostos....huosps..tp.l..tlhDLP-ElLphIhphChctphh..hshs.shRpppch.......................................................hl..spsCptl+pl.............p.hpshhsh.s.hhhpshph...stp	...............s..............p..phtsl..plhD.LP.-LLphlhcpCspsphhtl.ppsp.shh..shtph.....................................................................hl....spppphhpt..............................................hh..........................................................................................	0	24	26	31
+12855	PF13014	KH_3		KH domain	Coggill P	pcc	Wood V	Domain	KH motifs bind RNA in vitro [1]. This RNA-binding domain is required for the efficient anchoring of ASH1-mRNA to the distal tip of the daughter cell. ASH1 is a specific repressor of transcription that localizes asymmetrically to the daughter cell nucleus.  RNA localisation is a widespread mechanism for achieving localised protein synthesis [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-7.98	0.72	-4.24	992	970	2012-10-02 00:34:43	2010-07-21 15:11:14	1	161	261	0	679	13179	2478	42.40	26	10.20	CHANGED	hhutlI..G+s.Gp.s...Ipplp.ppo.u.sp.Iplsp..............sss.spchlplpG	...........hGtlI...G+s..Gp.s.......Icplp..ppo.G.sp.Iplsp.............................sss.spchlplpG....................................	0	314	459	633
+12856	PF13015	PRKCSH_1		Glucosidase II beta subunit-like protein	Coggill P	pcc	Wood V	Family	The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1]. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit [2].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.89	0.71	-4.75	5	406	2012-10-02 14:19:22	2010-07-21 15:42:45	1	19	259	0	274	570	7	146.00	26	30.43	CHANGED	Lp+clDEhcc-IcsI-p-lotlhEsLNpcaGhDDIaRAl-GppsscKlGGYsY+lsFhuSlaQ.....-DIpIGsFcctE...........Gs+LhY-cGuKCWNGP+RSAIVcVECGcsN-LlSVuEPEKCEYplpV+SPAuC...sss.hhKSLscE..EphAsF+I........s-hDEL	...................................................................................................................................tp..................t.......................t.......th...G....p.t.....at.....Lts..p...Ch.p..h.ptsp.Y.hYc..hC.........a...pp...spQp....................sttps.......p.........lGp...a...p....p..a.ph.................................................tph..h..s...h..h..ap..s..Gs.pC......W....N.....G.P........s.R.o.sp.......Vp.LtC....G...p.....p....s....c.....l....h..p.......V...s......E..Ps+..CpYthphpTPtsC...p................................................................................	0	110	156	224
+12857	PF13016	Gliadin		Cys-rich Gliadin N-terminal	Coggill P	pcc	manual	Family	This is a cysteine-rich N-terminal region of gliadin and avenin plant proteins. The exact function is not known.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.13	0.72	-3.78	28	2134	2012-10-01 19:46:35	2010-07-21 17:26:44	1	3	145	0	43	2573	0	79.20	44	32.15	CHANGED	QQQ..........hp..l.ppQLsPC+sFLhQQCsP........hhhsahpSphhQpSsCQVhQQQCCQQLtQIPcQsRCpAI+slVpAIIh	....................................................................................................................QQQ............hlQspl..pQQLsPC+sa.LhQ.Q.Css.......sh..sh..s...p.Sp.hhtpS.uC.p.lhQQQCCQQLsQIPpQsRCpAI+ullauII..........	1	0	3	21
+12858	PF13017	Maelstrom		piRNA pathway germ-plasm component	Zhang D, Coggill P	pcc	Zhang D	Family	Maelstrom is a germ-plasm component protein, that is shown to be functionally involved in the piRNA pathway. It is conserved throughout Eukaryota, though it appears to have been lost from all examined teleost fish species.  The domain architecture shows that it is coupled with several DNA- and RNA- related domains such as HMG box, SR-25-like and HDAC_interact domains.  Sequence analysis and fold recognition have found a distant similarity between Maelstrom domain and the DnaQ 3'-5' exonuclease family with the RNase H fold (Exonuc_X-T, Pfam:PF00929); notably, that the Maelstrom domains from basal eukaryotes contain the conserved 3'-5' exonuclease active site residues (Asp-Glu-Asp-His-Asp, DEDHD). However, the animal and some amoeba maelstrom contain another set of conserved residues (Glu-His-His-Cys-His-Cys, EHHCHC). This evolutionary link together with structural examinations leads to the hypothesis that Maelstrom domains may have a potential nuclease-transposase activity or RNA-binding ability that may be implicated in piRNA biogenesis. A protein function evolution mode, namely "active site switch", has been proposed [1], in which the amoeba Maelstrom domains are the possible evolutionary intermediates due to their harbouring of the specific characteristics of both 3'-5' exonuclease and Maelstrom domains.	18.90	18.90	18.90	21.20	18.70	18.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.26	0.70	-4.85	27	133	2012-10-03 01:22:09	2010-07-21 17:42:00	1	4	76	0	89	141	6	189.70	29	46.12	CHANGED	+......sschalPAEluhscaSLcp.G.lhs.apshIsPGpl.hG.hthcsppHop.sTHp.lPlsssshGcpshsplhpplhpalptp.........p........c.hs......................laopscplshVpsChcaLt............spsp...t..............lpVhslp.Lhhsl+ppshpht...p.h.shpls..sshhppsha-apsshuCpaHEc...spspaCshSh.VpRauahhschh...CtDluIphhss+H..........lP.ptcs	.................................................p...spptalPsEluhscaSLpp.G..IhspaHphIs.......P.G.plshG.hthcspttop.soHp.lP.lss........t.huc.shsplhpplhp...alpss.................t.........phs.......................laspscphshVp.Clcahs............ptsthppp..................lplhslppLhhtlhpp....th.........pp.stphs...pshhshsha-asssh..pCcaHEc...Dh.haCuhuh.sp+hu..aslss.h...sp.hulplp..tH...lP.p..s.....................................	2	26	30	64
+12859	PF13018	ESPR		Extended Signal Peptide of Type V secretion system	Coggill P, Desvaux M	pcc	Desvaux M	Domain	This conserved domain is called ESPR for Extended Signal Peptide Region. It is present at the N-terminus of the signal peptides of proteins belonging to the Type V secretion systems, including the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (TAAs). So far, the ESPR is present only in Gram-negative bacterial proteins originating from the classes Beta- and Gamma-proteobacteria. ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation. Deletion of ESPR causes mis-folding of the TAAs passenger domain in the periplasm , substantially impairing its translocation across the outer membrane [3].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.46	0.72	-6.70	0.72	-4.30	290	2495	2010-07-21 16:49:15	2010-07-21 17:49:15	1	530	854	0	281	2182	23	24.40	44	1.62	CHANGED	MN.+.lY+llWNcspss......alsVSE....l..u+	.....MN.K.lY+llWNcspus......alVsSE....l...A+........	0	52	130	207
+12860	PF13019	Telomere_Sde2	Ubiquitin-like;	Telomere stability and silencing	Wood V, Coggill P	pcc	Pfam-B_2457 (release 24.0)	Domain	Sde2 has been identified in fission yeast as an important factor in telomere formation and maintenance. This is a more N-terminal domain on these nuclear proteins, and is essential for telomeric silencing and genomic stability.	26.40	16.00	26.60	16.00	26.30	15.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.01	0.71	-4.55	20	270	2012-10-03 10:59:06	2010-07-21 17:50:03	1	9	236	0	202	1794	27	145.00	31	39.30	CHANGED	lNVLlooFsGhsLPsTLulsLPsooolo-Lhcclss+lPtohsp.....hhLTTsSN+tl.sssssslSsLlussss............shLsLRLss.LpGGKGGFGSQLR.AAGGRMSS++KpN..t-sNuSsRNLDGRRLRTVsEAKALAEYLAlKPEM-..........+K-KEtRR..................cRWcslVctsE+	.........................................................................................................................................................................hhshpLthR...LpGG..KG...GFGShLR.AhGuph...cKosN.......p-uC...RDL.s.GRRLRsVNctKtltE.altppsEc-..............+c...p+.ct....c.+..................pphcth.t.................................................................................	0	73	113	166
+12861	PF13020	DUF3883		Domain of unknown function (DUF3883)	Mistry J	jm14	Jackhmmer:O25123	Family	This is a domain is uncharacterised.  It is found on restriction endonucleases.	22.10	22.10	22.20	22.10	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.28	0.72	-4.25	140	729	2012-10-11 20:44:46	2010-07-22 11:22:32	1	17	639	0	217	541	130	96.80	24	14.27	CHANGED	sEphshphhhpt.ppt.........s.............ahsccs.t.........ps...hGYDItuh...........p..........sGp......p+a..IEVKupt............tttssht.lopNEhthAp..pps-..pYhLhhVhss.........ssps....phhhl	......................................hEphshphhpph.ptp.................s........................hphscspt..........pG.tGYDlhuh.........s...............psp....................pha..IEVKupp..........ptpsshh.lotsEhthup......ph..p..p..cYhlhhVhsh...scts..ph...h..........................	0	88	154	191
+12862	PF13021	DUF3885		Domain of unknown function (DUF3885)	Mistry J, Aldam G	gba	Pfam-B_1173 (release 24.0)	Family	A putative Rac prophage DNA binding protein. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YDDRG sequence motif. There is a single completely conserved residue D that may be functionally important.	21.80	21.80	22.40	24.00	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.82	0.72	-4.25	21	280	2010-07-22 13:00:10	2010-07-22 14:00:10	1	2	244	0	30	151	2	37.40	48	20.14	CHANGED	hHlYDDRGsDllusspcpLpsLYccascWILD..YDRpcI	.aHlYDDRGh-lhssNsEshtchhcKYpDhI.-.aDpEcI.......	0	9	21	26
+12863	PF13022	HTH_Tnp_1_2		Helix-turn-helix of insertion element transposase	Coggill P	pcc	pdb_2ao9	Domain	This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.96	0.71	-4.39	4	30	2012-10-04 14:01:12	2010-07-22 14:02:37	1	1	29	9	7	63	4	133.90	38	93.68	CHANGED	Mu+.hKpLEupLohcQRcAA.LLVtN...ELh.Ess.EKKTQ-ElApELGlsRhsLacWRTQspsFIsYhNhlADchLup+RspVYsQLM+hIpGsQ...PSVKAlDLFM+RaGLLTDKpVIE...Dsssssp+ost-IcpElscLsALl...K.c	...................Mu+.hccLctpLThpQhpAA.lLspN.....Elh.ps...s..cK+..TQ-ElApElGlsRoTLac.W.Rs.cNpsF.I.sa.p...s...clADshLup+RppV.....YspLh.phIhGsQ.......PSVKAhpLah.pRaGLLTD+.p.llc......sc.hssus+oN.t-IccplpcLpclht..c..........................................................	0	3	4	4
+12864	PF13023	HD_3		HD domain	Mistry J	jm14	Jackhmmer:O25415	Domain	HD domains are metal dependent phosphohydrolases.	21.60	21.60	21.60	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.12	0.71	-4.50	143	2536	2012-10-01 20:28:14	2010-07-22 14:13:12	1	13	2105	12	718	2045	280	160.20	26	71.76	CHANGED	h-+LKplhRpshhtss.p.RtEssAEHoW+lAlhuhlluths..s....ttlDhs+slpMh...LlHDlsEl.sGDhhshs....t.hsptt....pptcEppAtc+lash....LPps......tu.........pchtsLWp..............EFEs.......spos-A+a.............A+slD+hpPlltshtspspshtth.plphsphhsp.sptltps.tspla	....................h.s+LKhhpR..Wsh.....h.t...p........p...s...EsluEHohplAh....hA....h...h....l....s....t...hh.....s...........pl.s..h...p...+l...h.hhs.............lhHDhsEsl.sGDlssss.....................s...h...tpp......h...c...t...hE..p.t.A...pc.lh.sh.....lPpp..............hp.............................cpht.s.L.hp..............................Eapt............tps...-.u.ph............................s+thDtlpshl...ps...h.p.t.t..ts...tth...ht.t...................hh..............................................................................	0	211	416	587
+12865	PF13024	DUF3884		Protein of unknown function (DUF3884)	Mistry J, Aldam G	gba	Pfam-B_1352 (release 24.0)	Family	This family of proteins is functionally uncharacterised. However several proteins are annotated as Tagatose 1,6-diphosphate aldolase, but evidence to support this could not be found. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 106 amino acids in length. There are two completely conserved residues (Y and F) that may be functionally important.	21.70	21.70	22.20	22.00	20.20	17.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.88	0.72	-4.57	12	338	2010-07-22 13:17:09	2010-07-22 14:17:09	1	1	312	0	12	116	0	66.60	42	86.39	CHANGED	lacpVYllsFpchsp..phss..cLppLGcWhssoGppWhCHS...cLshs-FcptFhp..pLsssphthhpht.sahPap	........lY.lpF.chs....hsu..ccLKpLGcWhsoTG+.WhCHS...chph-EFKphFLp..hlss-chch.s.sssah.hp.......	0	1	3	7
+12866	PF13025	DUF3886		Protein of unknown function (DUF3886)	Mistry J, ALdam G	gba	Pfam-B_1536 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved L residues that may be functionally important.	25.00	25.00	31.80	31.10	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.50	0.72	-4.01	17	157	2010-07-22 13:20:39	2010-07-22 14:20:39	1	1	157	0	25	101	0	70.30	53	82.87	CHANGED	p......ptppcthoLKDtLss-lhtpLKttKcpLctcEpcRccccctc+tccp+c+EK..sKSFEELLsESpL.DW+c	...............QsccEslTLuDpLN-sLhppLKsKK+ELpscEE+KcAsEhcR+RpEpKEREK..NKSFEELLsESsL.sWKc..........	0	6	15	17
+12867	PF13026	DUF3887		Protein of unknown function (DUF3887)	Aldam G, Mistry J	gba	Pfam-B_1534 (release 24.0)	Family	This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 128 and 167 amino acids in length. The proteins in this family contain an N-terminal lipid attachment site.	24.50	24.10	24.60	24.20	23.10	23.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.40	0.72	-3.73	5	144	2010-07-22 13:28:10	2010-07-22 14:28:10	1	1	102	0	6	78	0	101.00	50	66.99	CHANGED	KEsKEcVcQSAE-pEsM...+sY+-VHcK.YDpKMNKELNpulpLaEpAKEKGGKsIspssaKEDVQKITsSMLEDID...HlRTEIRVPKSKEQEHclYlGFLNEoEQA	...KpsKEKVcpusEps.-h...+cY+tVHEK.aD..KMscpls.....hEsuKEKsucpIspAs.hhE-lpKl.Ts.shlEDhD......c.lpptIpVsK...cEpc+plhluFhsEsEpA...	0	1	4	4
+12868	PF13027	DUF3888		Protein of unknown function (DUF3888)	Mistry J, Aldam G	gba	Pfam-B_1080 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 111 and 149 amino acids in length.	22.20	21.80	22.20	21.80	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.76	0.72	-4.13	23	254	2010-07-22 13:30:48	2010-07-22 14:30:48	1	3	127	0	20	172	0	85.40	40	59.20	CHANGED	hpDslhshLtP.IscslpcaYuc........h.a..ppscllclc+hts.spa...Fhlslclpsa.....Gs+ssshupDplThpls.....stscllcacHhc	.....hEsALhshLashIppslEcQYt.........h.a..pCsclI...slK+lh.p.spal..Fplolphpsap....GspsPP.-KVTlThpsp......sclclpKlppc....	0	4	15	16
+12869	PF13028	DUF3889		Protein of unknown function (DUF3889)	Mistry J, Aldam G	gba	Pfam-B_1146 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (A and Y) that may be functionally important.	25.00	25.00	46.20	45.40	23.20	17.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.09	0.72	-4.33	19	153	2010-07-22 13:45:40	2010-07-22 14:45:40	1	3	127	0	20	104	0	96.20	45	78.51	CHANGED	llhshhhsh.hstsuhspsp...sshuKWt+lAhpcsKc+YPtAcllDYhalGRpptssp.oh-pF+lhL+cssK-FGVaVclpFcshTp+lhpIsl.Ep	..............lLhhsosushhsssulVcAp...PsYAKWGKLAVcKTKEpYPcA-IlDYLHlGR+s+TsphTVEKFKLWLREcGKEaGVFV-VpF-opT-KhIKloap+...	0	6	11	14
+12870	PF13029	DUF3890		Domain of unknown function (DUF3890)	Mistry J, Aldam G	gba	Pfam-B_1148 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 70 amino acids in length.	22.80	22.80	24.40	26.40	21.00	19.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.24	0.72	-3.93	6	114	2010-07-22 13:48:49	2010-07-22 14:48:49	1	1	28	0	9	75	0	76.90	64	51.96	CHANGED	Mspppsss-s.................lsclYpcIltLLslsccclSFpcFp.ahpLLEhIL.oRGIslpsLNhSphhLLlYYaI	..MSEQKsLQsQltuEEE.............LLVTKLHSEVLLLLGIDchALSRQNFLLHLSLLQAILVTRGIDASSLTYEQIFLLTFYHM.	0	6	6	6
+12871	PF13030	DUF3891		Protein of unknown function (DUF3891)	Aldam G, Mistry J	gba	Pfam-B_1216 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.	21.40	21.40	21.40	21.90	21.20	19.60	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.36	0.70	-4.87	29	151	2010-07-22 13:55:02	2010-07-22 14:55:02	1	2	146	0	32	130	3	223.80	44	89.22	CHANGED	MIlp....pptp.sahlIpQpsHuhluGplAtpWpps.hts.sphhtpslhAltpHDcGWhch-..tsPhls.....psutPhsFhchP...sph+lthappulspstpps.YuuLLsShHhstlhpppt...............spphppFlspphp+............QcplhpsLs..................hp........pt.hcppYtLLphsDpLSLhlChsc.....Puspctt-lshhtsu...........tpphpsp.tsssplplsPaPFppc.hslslph+tlspp	........MIhR....Ecs-.c.lLIcQHDHGaLAGEIA++h+-chF..........Es.c..........sahcETlsAIYEHDRGWIELD..+sPILND....ucshPYTFhDsP...........oslRhlFYolGLsEl.EssNPYuALLCS+HahSFshNc-.........................D-EhhuFaptEL-RQKRlLpsLo..................................p-........phshhD+HY+LL+FCD-LSLYVCMNc.........PGscKcpEIslFK-GFctoc...hssppcc.lpAcWlD-pTI+IoPFPFps-.FpshV+YKslsK........	0	13	26	28
+12872	PF13031	DUF3892		Protein of unknown function (DUF3892)	Aldam G, Mistry J	gba	Pfam-B_1252 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 87 and 104 amino acids in length.	22.30	22.30	22.30	23.60	22.10	20.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.94	0.72	-3.58	62	309	2010-07-22 13:57:37	2010-07-22 14:57:37	1	1	292	0	68	216	6	75.70	33	78.93	CHANGED	plsslp+ss.tus....Isplt......hssspth...ohppslphlcs..G..............thssVtVh.......tspsG.pcYl+op..sDuspssNL.sL...P	..............................pIssl+Kss..cGs....lhthp......tssGpph...sh.pulp.hcs.G.....................plstVsVh.........p+pG.pcalRop..sDGtppsNLtsLP.............	0	27	50	58
+12873	PF13032	DUF3893		Domain of unknown function (DUF3893)	Aldam G, Mistry J	gba	Pfam-B_1590 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 123 and 144 amino acids in length. There is a single completely conserved residue E that may be functionally important.	22.10	22.10	22.10	22.80	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.97	0.71	-4.06	15	111	2010-07-22 14:00:18	2010-07-22 15:00:18	1	2	106	0	18	96	1	127.70	47	17.45	CHANGED	lIRINss.....-VPsahsh-..p-pshsps....GLat.........cppslYYSsGphshstss.....p........................hhpppllEIlslGs..c.pcEt-plAchl...Hhhp..pushhhpcslphPhPhHhsKh.lKcYlss..Dshthcp.--p.c.-h	............................................lRI..Nsu....FDVPpYGVIE.....sD.....-sLDss................uLYh..........DQKGMYYSTGEYS...hNsSt...............................................hhp+YILEIhPLGV.............K.sVERsYIAKMl...HYMC.CNS.SMLhcKN..lHMPYsMHMAKV.IKsYhTD.IDAREFKEFDDELDVDl.............	1	1	13	16
+12874	PF13033	DUF3894		Protein of unknown function (DUF3894)	Mistry J, Aldam G	gba	Pfam-B_1594 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 79 amino acids in length. There are two conserved sequence motifs: FNIC and MALLNLT.	25.00	25.00	67.90	67.90	20.90	18.00	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.92	0.72	-3.96	3	82	2010-07-22 14:03:13	2010-07-22 15:03:13	1	1	82	0	3	25	0	52.10	94	74.74	CHANGED	LATFNICSYLVAIVCMALLNLTFVlGAFQQKQYTSFVhALhM.FSFSIVAIlLl	LATFNICSYLVAIVCMALLNLTFVIGAFQQKQYTSFVIALVMSFSFSIVAIVLY....	0	0	1	1
+12875	PF13034	DUF3895		Protein of unknown function (DUF3895)	Mistry J, Aldam G	gba	Pfam-B_1598 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (Y and L) that may be functionally important.	25.00	25.00	25.30	30.80	20.40	24.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.47	0.72	-4.50	11	104	2010-07-22 14:05:47	2010-07-22 15:05:47	1	2	87	0	5	53	0	76.10	69	54.50	CHANGED	L.sphppchlp.alpsp.....ptIoAp-lCEhLIcpsussscpYoTsKsKIYs.VC.aL-aLspcGhlhhlcshshpDRlYtp	...........LSPLQKDILE..LlsS.....EEISALELCEpLIRuGKIsDERFTTNKPKAYGQVCLlLEGFV+EGKLIFVKsDEKRDRVYK.L...............	0	0	3	4
+12876	PF13035	DUF3896		Protein of unknown function (DUF3896)	Mistry J, Aldam G	gba	Pfam-B_1603 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	122.80	122.60	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.15	0.72	-3.92	5	83	2010-07-22 14:08:07	2010-07-22 15:08:07	1	1	83	0	3	28	0	61.00	84	96.53	CHANGED	MK+TYDYsATKKHLELKKQpLCKKLSNh+LSEKEREQIKhEIDNYEYILNLVEMNHYERGF	MK.TYDYsATKKaLE.KKQQLCpKLssh+LScKEREQlKhEIDNYEYILNlVEMNHYERGF	0	0	1	1
+12877	PF13036	DUF3897		Protein of unknown function (DUF3897)	Mistry J	jm14	Jackhmmer:O25995	Family	This is a bacterial family of uncharacterised proteins.   Some of the proteins in this family are annotated as putative lipoproteins.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.84	0.71	-4.66	74	1082	2012-10-01 20:48:06	2010-07-22 15:45:39	1	3	1047	0	176	569	152	184.90	36	90.44	CHANGED	hhhsul...hluGC.............us.s.sphh-..s...............sss.shosshssp........DhphsApcMspshlssPhltphhtpss.t..sl..lhlss..lpNcTsp.pIso..cphssplpptLhpo..G+hph.....ssssphs.shppphp.pppsuhhspsostthGp.luApahLpGplssh..lc...pstpp.hhYphshpLhslpoGhllWsscppl	..............................................................hshAh...hLuGC...........................s...........s.....................sslsp.ssslppp...........s.tst..spchs.shhhpPh.VuphhtssGsp......sVlhV-s....V.pN+Tst..pl......ss.....schT..cs.lp.suL.tss...GKFsL.......Vusppls.hs+pQ.Lshpsp.D.uL.sspS....p....AIuhu.............+tVGA.pYsLYushSus....Vp......................................t.p....hpMpLM.lpTGcIlWoscssl................................................	0	49	94	138
+12878	PF13037	DUF3898		Domain of unknown function (DUF3898)	Mistry J, Aldam G	gba	Pfam-B_1179 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length. There are two conserved sequence motifs: DFG and FEKG.	25.00	25.00	40.70	40.50	17.50	15.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.75	0.72	-4.11	9	132	2010-07-22 15:16:23	2010-07-22 16:16:23	1	2	128	0	19	80	0	88.90	74	25.58	CHANGED	ElQEpaosEQVhEAoAtIlEppPElELKhKLschplKuhLADFG-olHlAKVNGRYVlLIEuDslpFEKGsSPVEFLKP-sLp-Vlc+Ipp	..EIMEQFSTEEVMEATAQIVEHAPEVELKLKADHISVKALLADFGDpIHIAKVNDRYVLMIEADTLTFEKGFSPIEFLKPDELQDVIERIEN.	0	6	12	13
+12879	PF13038	DUF3899		Domain of unknown function (DUF3899)	Mistry J, Aldam G	gba	Pfam-B_1174 (release 24.0)	Family	Putative Tryptophanyl-tRNA synthetase.	21.70	21.70	21.80	22.20	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.11	0.72	-3.83	37	490	2010-07-22 15:18:45	2010-07-22 16:18:45	1	2	484	0	38	179	2	87.20	36	73.50	CHANGED	hlNlhF.llullhlllGhhlhlhpsGh..FcshtauF++hppphtppp.tphhpp......p.....p.hhtshhhshhlss..hlhhlhslhltah	.....alNIhF.hluLhhhIhuhhlhlhQpGh..FDss.pauF+Rlph.........phppp.c.pc.Ipcs.......spc...........ch.phhlupa..hhslllhs....ILhhlholhlohh................	0	11	22	32
+12880	PF13039	DUF3900		Protein of unknown function (DUF3900)	Aldam G, Mistry J	gba	Pfam-B_1279 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 360 amino acids in length.	21.00	21.00	26.90	25.80	18.10	16.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.41	0.70	-4.83	8	130	2010-07-22 15:34:20	2010-07-22 16:34:20	1	2	127	0	19	78	0	246.30	79	69.68	CHANGED	DFTIpaLSFYVlpVEGcuEpssKpaKHaQTLDpspYEcSsLKDFLDGELtKIuKRKV-RHPKSEpsPTKIGRFlVEPGH-LDSNPNYNLFpRhRhAEThEsFp-tSEphV+oYLDTSAVRGGVFLVspA+L+KYaDDsFVFlhKCDFEpKVAsIoDpSTLI+cVEMAITTKNMKSIQYPYMPEEGMVEEuELKIHQuSHARYFEDFLKFVEYscSMPEIlKsQVhsMsp-HIt-Tap-pSEERppFEEslElW	.DFEINYLSFYVVQVEGKGEuVDKRYKHFQTLDAEEYEDSSLKEFLsGELLKISKRKVERHAKTEQAPTKIGRFIVEpGHELDSNPHYNLFNRIRFAETKENFKDMSEPLVYTYLDTSAVRGGVFLIAQAKLRKYFDDPFVFVMKCDFEPKVASISDESTLIRNVEMAITTKNMKSIQYPYMPEEGMVEsGELKIHQASHARYFEDFLKFVEYERSMPEIMKT.QVMDMVYDQIEDVFEE..GT.EEREQFDQAMEVW	0	6	12	13
+12881	PF13040	DUF3901		Protein of unknown function (DUF3901)	Misrty J, Aldam G	gba	Pfam-B_1316 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a single completely conserved residue L that may be functionally important.	25.00	25.00	43.40	43.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.92	0.72	-4.67	32	262	2010-07-22 15:36:13	2010-07-22 16:36:13	1	1	134	0	36	125	0	41.30	48	84.45	CHANGED	+K....p++.....hoFc-LVpENKcpLLsDpcth-cIEc+l-c+attp	..........R+.p+R......KSFcpLlpENKQpLLss+-shccIEERIEKRaph.......	0	8	23	26
+12882	PF13041	PPR_2		PPR repeat family 	Coggill P	pcc	Wood V	Repeat	This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins.\	  The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR [1].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.51	0.72	-3.99	436	33080	2012-10-11 20:01:03	2010-07-22 16:48:00	1	3913	396	0	23020	36618	476	49.20	26	28.42	CHANGED	P.....s....l....l...o.YNsllsu.hs..c.pu.c.h.....cc.Ahclap-Mp..c.p...G.h...p.Pss.hTYshLlpu.hCc	.......................shh.oasslIsu.hs.....c...p.....G...p..h...................cc...A.h.p..l.a....p....c..Mt.....p...p............G...l............p..P..sh..hTa.ss.llsu.hs...............................	0	2730	14486	19222
+12883	PF13042	DUF3902		Protein of unknown function (DUF3902)	Mistry J, Aldam G	gba	Pfam-B_1357 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a conserved LGI sequence motif.	25.00	25.00	92.50	92.40	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.24	0.71	-4.95	10	107	2010-07-22 15:54:01	2010-07-22 16:54:01	1	1	79	0	3	76	0	158.30	69	95.33	CHANGED	KuVLKsIlIShIFulsGhhhLLFsLh....hGsuDWlLsWlGVLMAYLSLahLIsLYs+sTYcKphsKlLlKosllSFshAVLGIhFGIlapLLssWSLolMhWYWLLlLlLaLhTIIoLVILVFVNppspsashlY+hLILLNlhLTLGPVLWPlhloIl.GNGM	......KSVLKSILISFVFSAVGMCWLLFlLF....+GDGDWLLSWlGVLMAYLSLYTLIDLYCKsTYDKKlsKhLIKTsVTSFSFuVLGISFsIIHELLTPWSLSLMVWYWLlMLlLFLTTIIoLV.LVFVNRKNHNFTssYRlLILLNlhLTLGPVLWPLLLoII.GNGM........	0	0	1	1
+12884	PF13043	DUF3903		Domain of unknown function (DUF3903)	Aldam G, Mistry J	gba	Pfam-B_1600 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.	25.00	25.00	51.40	88.80	22.50	21.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.85	0.72	-4.45	4	84	2010-07-22 16:14:07	2010-07-22 17:14:07	1	1	84	0	3	25	0	40.00	89	61.79	CHANGED	hsATSphLAIpKVRsECKRRFGKoLLLQTEIpEElhhcQK	VPATTQLLAIEKVRAECKRRFGKsLLLQTEIKEEIVFEQK	0	0	1	1
+12885	PF13044	DUF3904		Protein of unknown function (DUF3904)	Mistry J, Aldam G	gba	Pfam-B_1386 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in viruses. Proteins in this family are typically between 437 and 448 amino acids in length.	25.00	25.00	190.40	190.30	16.50	16.30	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.50	0.70	-6.06	2	198	2010-07-22 16:22:22	2010-07-22 17:22:22	1	1	2	0	0	189	0	398.50	96	99.09	CHANGED	LVLFLhKEVLCEPChC-NPTCLGlTIPpsGaVRSAPGGVLLTETITEpPtLsEWTTSRs+LE-ohW.sG-sKsGKVSQTLFEAIQGTQMENCAVKAVhDToFVNLT+pDlVLG+lKVS.FGG-pDISKCGRKGLKVFICGGTsGYVTRGCPPEEC+G+KGRMMuLEPTsDCGVEKGhTT-RIKTGhlDlsSCCTQHGCTKGIRVEVPSPVLVSuKCpEloFRVVPFHSVPD+LGFARTSSFTL+ANhsNpHGWSKYsFNLRuFPGEEFIKCCGFTLGlGGAWFQAYLNG.VQGDGAASA-DVKEKLNGIIDQINKsNhLLEGEIEAVRRIAYMNQASSLQNQVEIGLIGEYLNISSWLETpTLTKTEEGLMKsGWCpSssHCWCPPcsshlPTIGYVDsIKEVTGTSWWMVMIHYIIVGLIVlVlVVhGLKLWGCl	..................PChC-NPTCLGlTIPpsGaVRSAPGGVLLTETITEpPtLsEWTTSRsRLEDSsWpGGEVKSGKVSQTLFEAIQGTQMENCAVKAVFDTSFVNLTRHDVVLGRVKVSPFGGEHDISKCGRKGLKVFICGGTTGYVTRGCPPEECRGRKGRMMSLEPTADCGVEKGFTTERIKTGKVDLDSCCTQHGCTKGIRVEVPSPVLVSAKCNEISFRVVPFHSVPDRLGFARTSSFTLRAsLANQHGWSKYNF........N...........LR..........A...........FPGEEFIKCCGFTLGIGGAWFQAYLNGEVQGDGAASAEDVKEKLNGIIDQINKVNLLLEGEIEAVRRIAYMNQASSLQNQVEIGLIGEYLNISSWLETKTLTKTEEGLMKDGWCRSSNHCWCPPDTVGIPTIGYVDNIKEVTGTSWWMVMIHYIIVGLIVVVLVVLGLKLWGCI..	0	0	0	0
+12886	PF13045	DUF3905		Protein of unknown function (DUF3905)	Mistry J, Aldam G	gba	Pfam-B_1447 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	19.70	19.70	21.80	31.80	17.60	16.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.95	0.72	-4.21	7	99	2010-07-23 08:51:41	2010-07-23 09:51:41	1	1	99	0	10	51	0	82.80	83	71.87	CHANGED	csPhLDtThPHQIsh.PSFKGoGhphppPFVNpaGVVIGDSpYsS.NSPLppWSDEhDPulMAGDEWlHPTNDIGWpotENR-LL	.......QSPILDETLPHQMNF.PSFKGTGKpMQQPFVNQYDVVIGDSKYNSENSPLpNWSDEVDPAIMAGDEWIHPTNDIGWISEENQELL.............	0	4	7	8
+12887	PF13046	DUF3906		Protein of unknown function (DUF3906)	Mistry J, Aldam G	gba	Pfam-B_1532 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved EKK sequence motif.	25.00	25.00	51.20	51.00	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-9.01	0.72	-4.36	5	108	2010-07-23 08:53:15	2010-07-23 09:53:15	1	1	108	0	10	48	0	64.00	72	94.54	CHANGED	MaLYRFEAsl.cschlsIVIlApsEEpAF+LAElELEKaaLKlPslpElSLaEKK+Is+GAGYVl	.MDLYRFEAVL.sNSIVPIV..VVApSEEQAFKhAEIELEKHFLPLPEVKEIuLFEKKKIRKuAAFVI...	0	1	4	5
+12888	PF13047	DUF3907		Protein of unknown function (DUF3907)	Mistry J, Aldam G	gba	Pfam-B_1274 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length. There is a conserved AYTG sequence motif.	20.30	20.30	20.80	145.50	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.88	0.71	-4.59	16	138	2010-07-23 08:55:27	2010-07-23 09:55:27	1	1	138	0	20	93	0	147.50	63	90.38	CHANGED	Qs-pstphLpcslpplpsaLNppTLspLhpEp.su-c..sYYcslLusLR+LLVFsE-Gh-uCtllLpppsFccsAAEKsLYclYHQCIpEFFpPKpDsWYEDSRuAYTG+suIcF+ppsPpulcpLhhSlEutFpphREEL-YYETDYpT	..QTEQVuhFLE-sIslIosYlNaHTLPSLLEEossGsE..pYYKGlLuohRRLLVFCEEGtDAChVLLsSQPFRKTAAEKsLYKIYHQVIAEFFSPKuDpWYENSRSAYTGKNSIVFQQTPPASlEpVM+SLEGKFQlMREELEYYETDYQT..	2	5	11	13
+12889	PF13048	DUF3908		Protein of unknown function (DUF3908)	Mistry J, Aldam G	gba	Pfam-B_1533 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 140 amino acids in length. There is a single completely conserved residue Y that may be functionally important.	22.90	22.80	22.90	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.84	0.71	-4.17	9	99	2012-10-04 14:01:12	2010-07-23 09:58:18	1	1	97	0	5	46	0	121.50	72	89.42	CHANGED	shpphcchltpsphhpppsh...clhchh+clp.hL-..pshphhYPKNlFss..scclElhhhhpDs.hhhI.hppppc.thphchhph-slpcsplcpp.s...tshpLplhFssst.pIhhsSht..Ds..pp.ah..asc	...................NMKTIEEWIAESNARcEEDF..GpVVEEMKEVCl..GLD...NATLIYTKNVFCF..GKKVEVhFFFQDH..VVI.GQEK-E.YlEIEKLKYDsITpSNLKT..N..DKNTTLELKFANGQ.SINLDSLN..DNYGTKNWL..FAR.............	1	2	3	3
+12890	PF13049	DUF3910		Protein of unknown function (DUF3910)	Mistry J, Aldam G	gba	Pfam-B_1539 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	21.50	21.50	22.00	72.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.13	0.72	-3.90	6	84	2010-07-23 09:00:14	2010-07-23 10:00:14	1	1	84	0	3	46	0	92.40	90	91.92	CHANGED	MNlQAKVDWIGTPKPYIYK.DDVTYDAToIDFSLppDDNRYKLIVLKHEpssHYKhVQYGlKPGSQKPFPIDIPFcpsMLPLlEpILpDPYVQA	MNVQAKVDWIGTPKPYIYK.DEVTYDATSIDFSLAGDDNRYKLIVLKSEcNTHYKhVQYGIKPGSQKPFPIDIPFEQNMLPIIEQILHDPYVQA.	0	0	1	1
+12891	PF13050	DUF3911		Protein of unknown function (DUF3911)	Mistry J, Aldam G	gba	Pfam-B_1540 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	20.20	20.20	22.30	40.20	18.00	17.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.47	0.72	-3.87	5	86	2010-07-23 09:01:18	2010-07-23 10:01:18	1	1	85	0	3	28	1	76.10	94	94.08	CHANGED	MACVQIKGTRQEVVEMLQLFDLMDTKGFCKFDNYVEVEPNsccHNNFTASIDIQSNssSAQDp.LNDQFVSQMLTGVY	MACVQIKGTRQEVVEMLQLFDLMDTKGFCKFDNYVEVEPNsKEHNNFIASIDIHSNTSSAQDT.LNDQFVSQMLTGVY	0	0	1	1
+12892	PF13051	DUF3912		Protein of unknown function (DUF3912)	Mistry J, Aldam G	gba	Pfam-B_1615 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	21.80	21.80	21.80	148.90	20.90	21.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.29	0.72	-4.23	5	84	2010-07-23 09:02:45	2010-07-23 10:02:45	1	1	84	0	2	28	0	68.00	93	90.32	CHANGED	NFDIVGQKAYIKDGPHRNRIGIVKKNEcQLESpFAIVIGEQsIDVELKDIVLVGVDVGQFHcWCEQNG	NFDIVGQKAYIKDGPHRNRIGIVKKNETKLcSQFAIVIGEQsIDVELKDIVLVGVDVGQFHKWCEQNG	0	0	1	1
+12893	PF13052	DUF3913		Protein of unknown function (DUF3913)	Mistry J, Aldam G	gba	Pfam-B_1619 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	28.80	106.80	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-8.76	0.72	-4.03	2	84	2010-07-23 09:04:03	2010-07-23 10:04:03	1	1	84	0	3	13	0	56.80	97	93.66	CHANGED	KIhFYEKTAQ.DDLLGIWDNVPTIPRIGEKVEILKTlRTVTDIKYlKpGNNF+VEIl	KIWFYEKTAQLDDLLGIWDNVPTIPRIGEKVEILKTVRTVTDIKYVKNGNNFRVEII	0	0	1	1
+12894	PF13053	DUF3914		Protein of unknown function (DUF3914)	Mistry J, ALdam G	gba	Pfam-B_1562 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two conserved sequence motifs: KFDIR and DLW.	25.00	25.00	42.10	41.60	21.30	16.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.34	0.72	-3.83	5	85	2010-07-23 09:05:22	2010-07-23 10:05:22	1	1	80	0	3	51	0	88.00	89	78.88	CHANGED	MQIGLNlHTluQsTKlTPlslE+NTpusssppuKEssND.sIKFDIRSSEKEhKQucHKFTELDLWKMLKDKGVPLWIILEMLpKFRKEKEp	MQIGSNIHTLSQPTKITPSNLEHNTISSTKLESKK.lND.PIKFDIRSSEKEMKQPEHKFNELDLWKMLKDKGVPLWIILEMLQKsRKEKE.A	0	0	1	1
+12895	PF13054	DUF3915		Protein of unknown function (DUF3915)	Mistry J, ALdam G	gba	Pfam-B_1549 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	25.00	25.00	146.30	145.90	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-11.07	0.71	-4.14	5	84	2010-07-23 09:06:43	2010-07-23 10:06:43	1	1	84	0	3	45	0	119.00	86	97.62	CHANGED	MFGSFGCCDNF..RDCHH.....HEREp..HR...hcREKERc..hcspRsAVCNVLANISIGTEISLLolKGNGTFRNVIFEGFCNGVALFSALsh.ssDKD...sNKDDKNNpNpN..+FTGILRVCP-DIVAI	MFGSFGCCDNF..RDCHH...........HEREp....cR...-HREKERE..V+PQQPAVCNVLASISVGTELSLLSl+GsGoFNNVIFEGFsNGVALFSALAR.NssD.KD......NNKDDKpN..QN..R..N..TFTGILRVCPTDIVAI	0	0	1	1
+12896	PF13055	DUF3917		Protein of unknown function (DUF3917)	Mistry J, Aldam G	gba	Pfam-B_1608 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	25.00	25.00	149.20	148.60	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.43	0.72	-3.73	4	84	2010-07-23 09:41:22	2010-07-23 10:41:22	1	1	84	0	3	28	0	71.00	95	82.96	CHANGED	MTLKQNGLKRFVPGSILAGIALITYVsSIFlESlSl-hSTShhFIGITLFAGSlMVLMVAGIIlFIHMNSE	MTLKQNGLKRFVPGSILAGIALITYVISIFIESVSVDMSTSLMFhGITLFAuSIMVLMVAGIILFIHMNSE	0	0	1	1
+12897	PF13056	DUF3918		Protein of unknown function (DUF3918)	Mistry J, Aldam G	gba	Pfam-B_1567 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two completely conserved residues (G and R) that may be functionally important.	21.30	21.30	21.70	21.30	20.90	18.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-7.98	0.72	-4.64	11	120	2010-07-23 10:07:22	2010-07-23 11:07:22	1	1	120	0	13	31	1	42.20	66	98.98	CHANGED	MN+shTSLlAlGsGsAAYphAp+sDhMNsRsMKKhR+Rlh+hh	.MN.LRNSLIALGVGAAAYQYARKQDVFSKRNMKKARKMIKSYL	0	1	7	9
+12898	PF13057	DUF3919		Protein of unknown function (DUF3919)	Mistry J, Aldam G	gba	Pfam-B_1479 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 262 amino acids in length. There is a conserved YLNG sequence motif.	25.00	25.00	76.40	76.00	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.43	0.70	-4.89	13	118	2010-07-23 10:09:05	2010-07-23 11:09:05	1	1	111	0	10	94	0	220.90	57	86.08	CHANGED	cDKpsVlpphspSIPsKlclhsc+WGchslsDcspLppIhshlcpIspspoptss....csss.sIsGslaYLNGcKcoFplushLplssphYuss.hsshIstL+shLlshhYoPssLssllssssclIlhcp.ppspclssssKphIhspIcph+ploDsc-lt+hlspppcs.hhHI+lYhcscpt........cscspsllsIDVY-s.YhVVQYhGDENGpshYhKGsLsslhhK	..NDKQsVLQRVNESLPsElKVRHEKWGEIVlTDEVRLHTIVSFFDRIpIpPs-s.......KsQEQVFTGEVTYLNGpKRTFAVGDLFQYGsshYGKNGtDPMISAhQTYLLSLYYTPERIuDFF.ASApDVlV....RQGDVhRshNLTHILDSIRYAKQITDYGEIQKLLQSQNEP.IAYITAYKTGK........+lKN-REDILTISVYPS.YFVVQYLGDNNGNVMYMKuSLAplFVK..............	0	3	8	8
+12899	PF13058	DUF3920		Protein of unknown function (DUF3920)	Mistry J, Aldam G	gba	Pfam-B_1595 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.	25.00	25.00	26.20	83.30	21.40	18.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.74	0.71	-4.32	3	86	2010-07-23 10:10:41	2010-07-23 11:10:41	1	1	86	0	5	41	0	125.50	85	87.16	CHANGED	VLDSE.LPWDlQRl+sDlFSLIEKpchPVIFCDTCDANpVLhsLGEEEEEFLFPlGGFYHKEKQhIFVCMWEpYEQVLKTLLHEFRHuMQHEp-VLYVGpEsYEERhIEKD..ARtFAERKlDEYtcRs	VLDSE.LPWDVK+LR-DLFSLIElC.KTPVIFCDTCDAN+VLLSLGEEEEEFLFPlGGFYHKEKQLIFVCMWEEYEQVLKTLLHEFRHAMQ.....HKp-lLYVGSEpYEERWIEKD..ARKFAERKLDEYKNRK..	0	1	3	3
+12900	PF13059	DUF3922		Protein of unknown function (DUF3992)	Mistry J, Aldam G	gba	Pfam-B_1628 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 87 and 98 amino acids in length.	25.00	25.00	161.50	161.30	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.80	0.72	-3.79	9	83	2010-07-23 10:11:49	2010-07-23 11:11:49	1	1	82	0	3	40	0	78.90	94	86.70	CHANGED	FGMDKSKKLG-YVNALQALCEQYNVETDKIAIIEATEEYYLFLVKQE-CYDVVKVETVDTNI-YYTKAYKISSFNHTAY	FGMDKSKKLGDYVNALQALCEQYNVETDKIAIlEATEEYYLFLVKQE-CYDVVKVETVDTNIDYYTKAYKISSFNHTAY.	0	0	2	2
+12901	PF13060	DUF3921		Protein of unknown function (DUF3921)	Mistry J, Aldam G	gba	Pfam-B_1624 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	29.40	120.80	21.80	19.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.93	0.72	-4.09	3	83	2010-07-23 10:12:38	2010-07-23 11:12:38	1	1	81	0	3	28	0	57.70	95	91.77	CHANGED	MDGFQLSMIQKAIHRTYDELGKEIDLQGVlADEIQKAQEEYLSALSHETLIDKRYLKS	MDSFQLSMIQKAIHRTYDELGKElDSQGAIVDEIQKAQEEYLSALSHETAIDKRYLKS	0	0	1	1
+12902	PF13061	DUF3923		Protein of unknown function (DUF3923)	Mistry J, Aldam G	gba	Pfam-B_1586 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	26.60	26.20	22.10	20.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.00	0.72	-4.12	19	152	2010-07-23 10:14:53	2010-07-23 11:14:53	1	1	147	0	23	92	0	65.20	41	83.99	CHANGED	h+hahlsslhhlllFlhhuhhIahRcVDGuGlhQThph+hlslhlhslhhlllllhplIWhllh++	...ahsWWluNlhWlIlFshhAslIWlRcVDGAGVhQTsclK.IoLlVllIsallslhhQlIWLlIsh+...........	0	3	10	15
+12903	PF13062	DUF3924		Protein of unknown function (DUF3924)	Mistry J, Aldam G	gba	Pfam-B_1601 (release 24.0)	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	20.90	20.90	22.30	125.80	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.94	0.72	-4.10	2	84	2012-10-02 18:44:02	2010-07-23 11:16:03	1	1	84	0	3	14	0	62.00	96	96.87	CHANGED	MsTLTIELPp-hAEKLDLLKQsYpKKTGAoIS-S....TLISKEFlQtITPFDLQQal.tKE	MNTLTIELPKETAEKLDLLKQAYEKKTGASISESTLVQTLISKEFIQAITPFDLQQFIsGKE	0	0	1	1
+12904	PF13063	DUF3925		Protein of unknown function (DUF3925)	Mistry J, Aldam G	gba	Pfam-B_1644 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.	25.00	25.00	92.40	92.30	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.22	0.72	-3.94	2	82	2010-07-23 10:17:35	2010-07-23 11:17:35	1	1	81	0	4	27	0	65.50	95	94.02	CHANGED	MKTAQ+EhISNREFYFVLYMMLLaVhGWVhDVNGLFLSpYFsLAG.I.LPlVGGlVGhFlMSIsKE	MKTAQHETISNREFYFVLYMMLLYVhGWVIDVNGLFLSSYFNLAGEIMLPLVGGIVGLFVMSINK.Q	0	0	2	2
+12905	PF13064	DUF3927		Protein of unknown function (DUF3927)	Mistry J, Aldam G	gba	Pfam-B_1668 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 50 amino acids in length. There is a conserved SVL sequence motif. There is a single completely conserved residue D that may be functionally important.	18.60	18.60	19.80	21.50	16.30	18.10	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.12	0.72	-4.48	10	463	2010-07-23 10:19:14	2010-07-23 11:19:14	1	1	177	0	1	147	3	44.00	64	83.66	CHANGED	hchRLslAslLLFLVVhVDFTSRIMSVLADGsLVuulVllhWPllK	...........hKLpLhssslLLalsVMlDFTSRIMSVLADGsLVCGIVVLLWPllK..................	1	0	1	1
+12906	PF13065	DUF3928		Protein of unknown function (DUF3928)	Mistry J, Aldam G	gba	Pfam-B_1675 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	25.00	25.00	194.40	194.30	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.17	0.72	-3.70	6	81	2010-07-23 10:20:22	2010-07-23 11:20:22	1	1	81	0	3	16	0	95.00	97	97.76	CHANGED	MYTLKIVSDREAlYQFASYV+VVQGVEDVYVEVGEPLYEHPLMKFYVHIsIcETY-QpKALQEIARLVELGRFTYVHYRN-EIEcAFEAVKYESF	MYTLKIVSDREALYQFASYVRVVQGVEDVYVEVGEPLYEHPLMKFYVHIKLEETYEQHKALQEIARLVELGRFTYVHYRNDEIEEAFEAVKYESF	0	0	1	1
+12907	PF13066	DUF3929		Protein of unknown function (DUF3929)	Mistry J, Aldam G	gba	Pfam-B_1716 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.	25.00	25.00	151.10	150.80	23.80	18.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.23	0.72	-4.20	3	81	2010-07-23 10:22:33	2010-07-23 11:22:33	1	1	80	0	4	17	0	65.00	97	95.14	CHANGED	MVYHLENGETIKDIKEFCYRDpGKMLERVAHRVMDN+EVTAIDKQGTIISIAC-DIVKVELDYIp	MVYHLENGETIKDVKEFCYRDQGKVLERVAHRVMDNREVTAIDKQGTIISIACEDIVKVELDYIT	0	0	2	2
+12908	PF13067	DUF3930		Protein of unknown function (DUF3930)	Mistry J, Aldam G	gba	Pfam-B_1721 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 51 and 67 amino acids in length.	25.00	25.00	63.80	58.90	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.38	0.72	-4.11	4	87	2010-07-23 10:23:47	2010-07-23 11:23:47	1	2	80	0	3	25	0	52.00	82	95.06	CHANGED	M.......p+ppcahaE......IhKhlFlFhpshslshsthhlVQhIhph	.MEYQYE....V....G....QTKEEFMHEDQWADSLIKWLFIFLIIVGIPYTAYVVVQFILSF.	0	0	2	2
+12909	PF13068	DUF3932		Protein of unknown function (DUF3932)	Mistry J, Aldam G	gba	Pfam-B_1731 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	173.90	173.80	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.78	0.72	-3.89	2	80	2010-07-23 10:52:45	2010-07-23 11:52:45	1	1	80	0	3	20	1	81.00	93	97.49	CHANGED	MKEsFRLQTDFSSSFDRWVSSFVSsaPsQLcWoTLKELIHEYTooHTNpolPpYISSuhTYYAQRlSTANNoEIlIapN.T	MKEsFRLQTDFSSSFDRWVSSFVSDHPAQLEWTTLKELIHEYTToHTNDoLPTYISSAlTYYAQRVSTsNNSEIVIFEN.T.	0	0	1	1
+12910	PF13069	DUF3933		Protein of unknown function (DUF3933)	Mistry J, Aldam G	gba	Pfam-B_1720 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	25.10	98.90	22.90	16.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.53	0.72	-4.27	4	81	2010-07-23 10:53:53	2010-07-23 11:53:53	1	1	81	0	3	24	0	52.50	93	95.15	CHANGED	MKQYVICQlIsGsKYLAAYAETKQEAIEKAELLGLRTGsRYlVITAEEA-GLp	.MKQYVICQIINGEKYLAAYAETKQEAIEKAELLGLRTGNRYhVITAEEAEGLT	0	0	1	1
+12911	PF13070	DUF3934		Protein of unknown function (DUF3934)	Mistry J, Aldam G	gba	Pfam-B_1719 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two conserved sequence motifs: GTG and SKG.	25.00	25.00	31.30	31.30	19.40	15.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.29	0.72	-3.73	5	100	2010-07-23 10:55:23	2010-07-23 11:55:23	1	1	99	0	10	25	0	41.50	85	88.81	CHANGED	MSKoK..sKuGTGpGTGKKGWNRWQuSAK+.KKuAKPY..pSKGT	..MSKTKAKPKKGVGQGTGSKGWNRWQSSAK..K..KKAAKPY..KSKGT......	0	2	6	6
+12912	PF13071	DUF3935		Protein of unknown function (DUF3935)	Mistry J, Aldam G	gba	Pfam-B_1715 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two conserved sequence motifs: FVF and LGV.	25.00	25.00	37.30	78.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.19	0.72	-3.59	3	83	2010-07-23 11:43:06	2010-07-23 12:43:06	1	1	83	0	3	36	0	70.70	95	76.27	CHANGED	MTRLKQIFGIhISFFVFWFSMLGVQM.FAEFLDI-SLKFluGKTEsARAFLFsYPaFIlFLl...ShYh.FlI	.MTRLKQVFGIIISFFVFWFSMLGVQM.FAEFLDIESLKFVAGKTEAARAFYSPYPFLIVFLIT..LLSLYF.FVI..	0	0	1	1
+12913	PF13072	DUF3936		Protein of unknown function (DUF3936)	Mistry J, Aldam G	gba	Pfam-B_1705 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue G that may be functionally important.	21.80	21.80	21.80	29.00	21.20	21.70	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.70	0.72	-4.50	7	122	2010-07-23 11:44:47	2010-07-23 12:44:47	1	1	122	0	13	56	0	37.40	68	82.30	CHANGED	MKlahhscullLsGKAWEIRtKLKcYsppaphVp-Wls	MKVYILPNRVTLVGKAWQIRHKLKQYGKEYTTVQEWIT......	0	2	8	9
+12914	PF13073	DUF3937		Protein of unknown function (DUF3937)	Mistry J, Aldam G	gba	Pfam-B_1711 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	22.50	22.50	22.50	75.40	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.25	0.72	-4.09	7	81	2010-07-23 11:45:39	2010-07-23 12:45:39	1	1	73	0	3	31	0	72.30	81	90.49	CHANGED	MFpNKKLIRhGLoLFlhLslIsFTIuYFQoYLcSAssIcWllschW+TILlDAPcGILVlLGAIALY-FTKcs	.MFTNKKLIRFGLTLhVhLhlIsFTISYFQTYLESAAGIKWVIsEhW+TILLDsPEuILVILGAIALYDFTKET.	0	0	1	1
+12915	PF13074	DUF3938		Protein of unknown function (DUF3938)	Mistry J, Aldam G	gba	Pfam-B_1607 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.	25.00	25.00	209.70	209.20	24.40	19.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.36	0.72	-4.17	6	83	2010-07-23 11:46:34	2010-07-23 12:46:34	1	1	83	0	3	21	0	102.00	96	80.04	CHANGED	NlQLGEpIIFNGIEoLVSASILGGYIaFLFNPEENAQKTMLLTMIGIVGGCISYSMTNYTLPLQLSSAFFHGLWTWFIAFCLADVFNLLQDsEE-sGRpIES	.NTQLGENIIFNGIETLVSASILGGYIaFLFNPEENAQKTMLLTMIGIVGGCISYSMTNYTLPLQLSSAFFHGLWTWFIAFCLADVFNLLQDNEEENGRQIES.....	0	0	1	1
+12916	PF13075	DUF3939		Protein of unknown function (DUF3939)	Mistry J, Aldam G	gba	Pfam-B_1535 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.	21.30	21.30	21.90	21.40	20.90	19.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.70	0.71	-4.45	6	100	2010-07-23 11:48:02	2010-07-23 12:48:02	1	2	96	0	9	42	0	135.70	75	85.22	CHANGED	pcpt.ctlcVTlDEVR+AlpcatpshscGIshpsLlpsspcIDhctLtsaLGGhPcQhFYMS+ETaEIF...tEE+-lsh.lDhVQlAVDpYlp-ptchPlhpsspshpVshpKL..ptYLcEhPpa.sLYls-pphlVohcPcp	........F.+TGKEEREITKDELEQAMApFLEp.NANIVYTVLVNDDYTVNYDLLKPYLPAFPTNhFLITKETLEVFEHTEENLNLVKE.IDlVQKAVDQYVTEKEMFPIVEGS......ED......RLICGMKL..GPYLsRlLKR.DLYISEKHYLVSSKPDR.....	0	4	6	7
+12917	PF13076	DUF3940		Protein of unknown function (DUF3940)	Mistry J, Aldam G	gba	Pfam-B_1673 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 50 amino acids in length.	21.70	21.70	21.90	22.80	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.48	0.72	-4.41	29	195	2010-07-23 11:49:13	2010-07-23 12:49:13	1	1	129	0	24	102	0	37.80	50	66.79	CHANGED	pcKphLIppLIppGlaKtpc..RpLaEhohpELcc.Ycph	......+KcaLI-cLIssGlaKhcD..RQLYELSLpELE+EYcs.h.........	1	1	14	16
+12918	PF13077	DUF3909		Protein of unknown function (DUF3909)	Mistry J, Aldam G	gba 	Pfam-B_1537 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	25.00	25.00	211.60	211.50	20.00	18.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.59	0.72	-4.18	11	84	2010-07-23 11:57:32	2010-07-23 12:57:32	1	1	84	0	3	30	0	107.80	93	97.97	CHANGED	MDLQKFDtMIDAVQRATClpIN-KQKEAFKQKYDFEPpFEYGRDEKGHYVIRTSKKMLEEMEFYLALKYDRDGlDLYMcAEIDGlCHVSVSYSEDALHLQELFQFLEE	MDLQKFDEMIDsVQRATClQINEKQKEAFKQKYDFEPcFEYGRDEKGHYVIRTSKKMLEEMEFYLALKYDRDGVDLYMQAEIDGIhHVSlSYSEDALHLQELFQFLEE	0	0	1	1
+12919	PF13078	DUF3942		Protein of unknown function (DUF3942)	Mistry J, Aldam G	gba	Pfam-B_1722 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.	25.00	25.00	99.80	99.70	21.30	19.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.67	0.71	-4.03	5	85	2010-07-23 12:01:07	2010-07-23 13:01:07	1	1	81	0	4	34	0	124.20	88	93.83	CHANGED	LDEFsp+VKEYL-sEK-EKIIK-GHRDVIFpYLYcLEscIGVV+NP-FsFFTSGcRSHIVlENlEFKTEVcsE+NIIEITKIVDpVA.TsLDTIIlQDGELFALGRNEKFTppILp-YLpEsFuEhL	R.FEFTTKlKEYLDDEKDEKIIKDGHRDIIFpYLYsLESEIGlhKNPNFTFFASGRRSHIVLENIEFKTEVNVKSNIIEITKIVDNVV.IPLDTIVAKDRELFALGRNEKFSVQILEQYLFDTFGEKL...	0	0	2	2
+12920	PF13079	DUF3916		Protein of unknown function (DUF3916)	Mistry J, Aldam G	gba	Pfam-B_1564 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a single completely conserved residue S that may be functionally important.	21.30	21.30	21.80	21.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.73	0.71	-4.55	14	109	2010-07-23 12:11:47	2010-07-23 13:11:47	1	1	107	0	11	80	1	146.20	59	82.08	CHANGED	hhcphptph.shPsshasstY..Wph+lPVstualpup+sspplKphClQsLlspAppLhphKsssppphRVsshIslssLasSpIllF..cs..-cYFcsFhsRss.chppWlsLsspcsltpcWsLplssshpphGapElhpDp-...s..tcpElWaIGE	................MIKRIEEHTKsFPSTFYND..EY..W.M.LPVSQsFI-S+KTPRKVKRLCIQTLlspsNHLIph.K.PoDTHTYRVVsLISIpNLWcSQIIlF..KN..-DYFHNFFNRss.EFQKWIhLSNElDFWETWtISIssohphL+FQElIYDED...t...EKEIWFIGE............	0	0	4	7
+12921	PF13080	DUF3926		Protein of unknown function (DUF3926)	Mistry J, Aldam G	gba	Pfam-B_1663 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 46 and 63 amino acids in length. There is a single completely conserved residue P that may be functionally important.	25.00	25.00	26.10	82.60	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.23	0.72	-4.42	8	78	2010-07-23 12:15:49	2010-07-23 13:15:49	1	1	77	0	3	35	0	44.00	80	80.29	CHANGED	MpILcELPsPIQQSAKpMLNILQEELSSYspEpsQspsNLKsII	MHILEELPsPIQQSAKQhLNILQEELuuYPpEQsHHcsNLKNII	0	0	2	2
+12922	PF13081	DUF3941		Domain of unknown function (DUF3941)	Mistry J, Aldam G	gba	Pfam-B_1728 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 30 amino acids in length. There is a conserved YSK sequence motif.	25.00	25.00	28.70	43.80	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-6.85	0.72	-3.95	5	93	2010-07-23 12:21:47	2010-07-23 13:21:47	1	1	93	0	8	35	0	24.00	82	47.55	CHANGED	RccKNpt+..cKNtQpGK+AYSKKTD	.RsQKNEQE..QKNIpQGKRAYSKKTD.	0	1	4	5
+12923	PF13082	DUF3931		Protein of unknown function (DUF3931)	Mistry J, Aldam G	gba	Pfam-B_1734 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	40.30	161.30	21.50	18.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.32	0.72	-4.11	4	82	2010-07-23 12:31:39	2010-07-23 13:31:39	1	1	82	0	3	10	0	66.00	98	78.64	CHANGED	MDNNEKKCNVISIDGKKKKS-TYSYPKLVVEsKTYEFSSFVLCGETPDGRRLVLTHMISTDEFAGF	MDNNEKKCNVISIDGKKKKSDTYSYPKLVVENKTYEFSSFVLCGETPDGRRLVLTHMISTDEFAGF	0	0	1	1
+12924	PF13083	KH_4		KH domain	Bateman A	agb	Jackhmmer:O25768	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.30	0.72	-4.34	211	3577	2012-10-02 00:34:43	2010-07-23 16:26:45	1	7	2027	3	775	2186	412	73.20	25	47.89	CHANGED	cch...l...cplhcsllpp...p...plplptp.....p.c.ppthlplpl.sspD.hGplIG+cG+slpAlphllsss.s.s+...p.s..p...c...h..plpl	.....................................thlpthlcsllst..s.c.....sl.p.lphp......psp..pttplpl.pl...s.s.p.D....hG+..lIG+pG+slpAlc.t.llpsss..s.+....t..s..p....p.h.hl.....................................	0	331	604	701
+12925	PF13084	DUF3943		Domain of unknown function (DUF3943)	Bateman A	agb	Jackhmmer:O25483	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.	27.00	27.00	27.90	81.00	22.90	21.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.20	0.72	-4.48	33	236	2010-07-23 16:14:36	2010-07-23 17:14:36	1	2	221	0	52	187	8	110.00	50	30.54	CHANGED	puhha................DsDsahhNhhuHPYtGuhYassARssGashapShhaohsuShh.WEhusEs..EhPSlpDllsTsluGhllGEhhac.huphl....tsutphhsppshu....hllsPhs	..................p.GPsWDcDpahhNhlhHPYFGulYYsAARpAGas.acShhYShshSThFWEYGlEAFsEVPSWQDlhlTPhhGullGEhhac.hpptI.....hssGGclhGS-hhGthslhhlsPl.G..............	0	21	33	45
+12926	PF13085	Fer2_3		2Fe-2S iron-sulfur cluster binding domain	Bateman A	agb	Jackhmmer:O25214	Domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.45	0.72	-4.23	52	5265	2012-10-02 17:47:23	2010-07-24 12:26:47	1	25	3727	84	1318	3398	2510	108.10	39	42.50	CHANGED	plclhRhss................................................................tt.psahpsaplshc..ptholL-sLptIcpp..........-ssluac..tuCppulCGoCuhhlNGcs......pLACpshlpshhpt...............................................lplpPL..spaPVl+DLlV........Dhsshhc	............................................................................................................................................................................hplaRasP....................................................................p.ss....pPphps.Y..pl...c...hp...pshhlLDuLh.hlKcp...........DssLoFR...pS.CR.E.GlCGSCuM.lNGps...........pLACpsh....lcshs.p..t...........................................................................................lp.lcPL...ssh.PVl+DLlV..DhopFh.t.....................................................................................	0	387	813	1105
+12927	PF13086	AAA_11		AAA domain	Bateman A	agb	Jackhmmer:O25195	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.79	0.70	-4.79	118	5668	2012-10-05 12:31:09	2010-07-24 13:20:17	1	234	1842	10	3094	6877	709	222.70	20	21.82	CHANGED	pLNpsQtpAl...ppslsppt......................hsLlpGP.............P.............GT........GKT...polstlltth...................................................................................................................................................................................tttsp+lLlsusSNsAVDpllp+...Lhp.................hph...............pllRlGpsp.........psslpphs....hpt.h.........................................................................................................................................................................httphtphppthpth.pthtt.ptth............ppllppupllhsThsuu.upthhpph..................pF-hlIlDEAuQ.............usEsssLlPl..hhu.............c+hlL...................lGD.pQLPPslhSp	.............................................................................................................................................................................................................................................................................................................................................................................................Q..uh...........h.h.t.............................h.l...G..P.............P.......................GT...............GKT...........h.hh..t..hh...h...................................................................................................................................................................................................................................................................................................................t..hl.hh..s.s..s......A.hs...hh.t...h.t...............................................................................................................h.h.R..hh..t.....................................h...........h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..h...t..t...h......p.....l......l........h..s..T....h.....ss..........p............h.t.t..h..............................................................th..c..hl.l...lD..E.....A....uQ................................h...h..t.......p......s..hh...s...l.......hhs...........................pphl...l...................................lG...........D..pQLsPhh...................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1106	1755	2545
+12928	PF13087	AAA_12		AAA domain	Bateman A	agb	Jackhmmer:O25195	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.41	0.71	-4.94	125	5685	2012-10-05 12:31:09	2010-07-25 09:30:25	1	268	2107	10	3041	5759	458	189.40	23	15.53	CHANGED	hspSLF-RLhptt.................ttshhLshQYRMHspItp...FsSphFYp...Gc....Lpsus......shtppph..............................................................h.tshtP.lhFhcs................................sssppppppt...............sShhN.sEAphlhpllppLhpptstt..................pcI..GlIoPYpuQlphl+phlp.........p..............................pht.t......................................lclsTVDuFQG+E+-lIIhSsVRo...............s......pps.......................................................s....lG.FLsDhRRlNVAlTRAKptLlllGssp	...........................................................................................................................................................ohh.hh............................................hhLphp.a.R.h.p...p.lhp...h...s.s.....p.hh.Y.p...........s.p.......L..sts..................phtp.t.........................................................................................................................................................................................s...hhh.hss........................................................ts......t..ttt...t...............................tuhhN...tE.u........p.h..l.h.p.....hl...p.t.hh....pt..thtt.................................ppl......u.l..l....o....P...Y..p..u..Q...h..p..h...l..p..ph..l..p..........p..................................................................................................................................t..h......t..t.................................................................................................lp..l.sT.V.-s...a..Q............GpE.p-.l.lll..S..h.....V..cs.........s..................tpt............................................................................................................................s........hG....F..l.......p....s.............c.....R........l....N..VAlo.RA+pt.lhllGs..p..........................................................	0	1103	1793	2543
+12929	PF13088	BNR_2		BNR repeat-like domain	Bateman A	agb	Jackhmmer:O25303	Domain	This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.30	0.70	-5.11	78	2868	2012-10-02 00:45:24	2010-07-25 11:16:42	1	108	1391	46	640	2427	442	267.90	18	47.16	CHANGED	Gp...LlAhWFu.........GscEG..ssDlsIhho......ppp.ss.....p.......W..ussthlssst......................................htshtNPllht...ts.supLhLF...atssssss...............tWh...........uhh......hpSsD.......sGt..o.Wotsp....cLssu..........hsGsl+s....................s....lhhp....sG.pllhP...s.pE.......tt....ashhlthosDsuts.........Wppsphh.................................ph.stlQPoll..ss.......u..plhhhhRs..tps............plhtotSpDsGpoW..ss.......sp..........hslPNss....Sulsuls.LtsG..phlLshN........................................................RssLsl.....th..........SpDt.GpsWp.thhsL-sss......................................................phSYPsllpssc......s..plal	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s...h..........................t....s..lh......h......h..................................................................................................................................................t..................hpSsD..................sG.p.....T.....Wotsp..................pls.t.....................hh.h..h...s..s.spu..............................................................................................l..hp.............sG..cllhs...................shtp..........................ttt........ps.h.h..h....hS...c..DpG.pT.........Wphu.pss.........................................................................................ph..sps...ps...s....l....s..s........G.....slh.h..h.....h...Rs....ss.....................phhh.u.tSpD..s.......Gt.....TW....st............................................sp................................h.s..h...s..s......s...............u..sh..p.....h.h..p.....h.t...ss.........phhlh.hs..........s.pt....................................................................Rt...h..s..l..th...............s..t..Ds...uh.....sW.....hh.....l...p..s......................................................................huYsshh..ss.................................................................................................................	0	246	392	511
+12930	PF13089	PP_kinase_N		Polyphosphate kinase N-terminal domain	Bateman A	agb	Splitting PF02503 into domains	Domain	Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.	21.90	21.90	21.90	21.90	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.49	0.72	-3.96	174	3094	2010-07-25 13:24:08	2010-07-25 14:24:08	1	9	2787	6	696	2356	835	105.30	41	15.31	CHANGED	hahNRELSWLpFNpRVLpEAtD.p.p.hPLLERl+FLuIhoSNLDEFFhVRVAuL+p...............plptuhsphs..sGho.............Ppcp.LptIpppspphhccptphapp.lhstLt.cpuIpllp	......alsRELSWLsFNpRVLppAtD.p.s.hP.....LLERh+FLuIaosNLDEFahVRVAuLKc...............plphu..h...pp....tu....ssu.h.s.............spc..LspIppcsp.chhpcp....tplas-.lhspLt.cp.sIhll.p.........................................	0	209	457	597
+12931	PF13090	PP_kinase_C		Polyphosphate kinase C-terminal domain	Bateman A	agb	Splitting PF02503 into domains	Domain	Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. This C-terminal domain has a structure similar to phospholipase D.	23.90	23.90	23.90	24.70	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.90	0.70	-5.85	174	3665	2012-10-02 13:01:53	2010-07-25 14:32:09	1	10	2915	6	706	2979	1325	303.40	49	47.92	CHANGED	slFssIcc.pDlLLHHPYcSFssVlc.FlcpAApDPsVlAIK.TLYRsu.scSsIlpALlcAAcsGKpVTVlVELKARFDE-sNIpWA+pLEcAGs+VlYGlsGLKTHuKlsLlVR+..Ets.t.....l++YsHlGTGNYNspTA+lYTDhuLhTscpplupDlsclFshL.oGh...uc.s......phc+LhluPhsl+ppllchIccEhppActGc.sutIhhKhNSLsD.plIctLYcASpAGVcI-LIVRGICsL+PGlsGlSENIcVpSIVGRFLEHoRlahFtN.s...........G..........csclYluSADhMsRNLc+RVElhhPlhDspl+pclhch.LphhLpDNspuhtlpsDGsYpphps..p..........pp.h.suQphhhpth..p	......................................................................slFcuIRc.p.D.lLLHHPYcSFs.s.Vlc.hLcQAAtDPpVlAIK.TlYR.su...p.D.....S.IlpuLlcA...Acs.GKpVTVlVEL.p..A..RFD..E...EuNIpW.A.+cLEcAG.sHVla...G..hs..G...l....K.sHuKlhL.lsR+..E......ss....p..............lhcYsHlGTGNap...tTA+lYTD.hulhTss.plsp-spplFs...l..p.s........p..............................p....hp.....pL...hhu...P.sh+ptlhchIcpE.htt..t.p......tG....h......u........tIhhKhNsLsD.....tllctLYtASpuGVplcLll.R......Gh.CsL.hP..s.l.Gl.......S-....N....IclhSIl..sRaLE.HsRlahFts.s.................s..........................p.....plaluSADhMtRNlpp.RlEshhPlhs.plptplhp..hph.htDshpuh.lpt.-hp.thh.......t...........p.t..h.puQ.hhhp..h...........................................................................	0	212	466	607
+12932	PF13091	PLDc_2		PLD-like domain	Bateman A	agb	Jackhmmer:O26029	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.17	0.71	-4.38	205	18675	2012-10-02 13:01:53	2010-07-25 14:56:24	1	85	4401	14	4237	15098	1180	139.20	19	41.80	CHANGED	lhphlpp...up..cplpl.ssh..ah.............ppp.....l....hpsl.ht.ttp+G.lcl+llhsp..............................................p..h.thtthpthtph.hptshp..........h..........................................HsKhhll.D.......sp......................h.sh.l..GSsNhotpuh.........ptNh......Ehs......lhlp.sp........thspphpp..hF...pt...a	....................................................................................................................................................................h..phlpp..Ac.....cplhl.ts..ha.......................................s.spp....l........hpsL...hp....sspc.....G...V.......c..V..+..l..lhs.s..s...............................................................................................................h.....h.ts.hph.h.t.ph....h.p.s.Glc.lhhh..........................................................................tts..hhHpKhhll..D.......sp.........................................................................hsh.l...G.o..h.N....h.....s..s..c.uh...............thsh........................E.hs.............lh..lp...s............t.stthtt..h...........................................................	0	1240	2500	3500
+12933	PF13092	CENP-L		Kinetochore complex Sim4 subunit Fta1	Coggill P	pcc	Wood V	Family	CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2]. Fta1 is the equivalent component of the fission yeast Sim4 complex [1]. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.	21.70	21.70	21.90	22.10	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.85	0.71	-4.46	30	154	2010-07-26 14:40:08	2010-07-26 15:40:08	1	5	141	0	110	144	1	169.30	25	45.25	CHANGED	pshTpLPLLLsRhPssLRpshhoFLupsFDspsSsLRLsophLssshEpalsslspssss.....................plh+-hpLTLuFs.sssss.......................uL+olslsIPtpslssFhptu.....................................tt.psp.s....ssFhsuLusYhcpHLAhcLs.................tttl+LoKlusuuFllusEGRlKlluss	..............................................................................................phspLPLhLsphspshp.phlhsalppsFD...shho..sL....p....lsspsLshhhthahsshsppths..........................................phplhas.sstss.................................slpslsltIs.cchpshhpps......................................................t.s.t.p..pp.pps.....s.FhpsLtsahcc.Hhtlc.Ls.................................................................ss+Ls+lusushsht..s....-G+lKlhs..t..................................................	0	24	43	77
+12934	PF13093	FTA4	CENP-U;	Kinetochore complex Fta4 of Sim4 subunit, or CENP-50	Coggill P	pcc	Wood V	Family	Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1 [1].	24.80	24.20	24.80	24.80	23.50	23.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.38	0.70	-4.90	31	102	2010-07-26 14:45:24	2010-07-26 15:45:24	1	3	88	0	82	102	0	200.70	30	81.33	CHANGED	Msto.p.......olhplKpsFlcsQl...+ILSpsL.........pssccW+shst.ts.pp...............p.............Ls-.......+slpclLpKlNstL+pHsRtlaSsQAlpHVApQItpLYhpphtpsspp.sphpthlc.............................cssDLos...........ptsIppLPp......................................................................ph.t.....ps...ssppptp......................+YpcLppcLlpLsppppptpc+LsphppLpplL...........................EPacsspp........................slQsNLl.....o+supLspEl..p+MRhLls+Vuu+	.................................t......pl.phKpsFlpsQh...+lLSpsL.........tPsc..sW+shst..stpp.........................s........lsp.......+slpcsLt+lNthl.ppHsRtlassQAhp+VApQIppLYhpphpttst.p..p.t.hlp.............................ctsDLss...........tt.IppL.Pt.......................................................................ph.t............t.p.tptp......................+YtplhtcLhpLspp+pphpp+ltph+pLpphl...........................cPapsspp............................................slQ..NLl.....T+su.lttEl..p+MRhLlu+Vss+.........................................	0	14	40	68
+12935	PF13094	CENP-Q		CENP-Q, a CENPA-CAD centromere complex subunit	Coggill P	pcc	Wood V	Family	CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2]. Fta7 is the equivalent component of the fission yeast Sim4 complex [1].	28.50	28.50	31.00	29.90	27.80	28.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.05	0.71	-4.21	38	159	2010-07-26 14:57:46	2010-07-26 15:57:46	1	3	124	0	96	153	0	156.00	22	39.12	CHANGED	pLtp+Lsp.hshPsts...................pcs.hsh-plhpppptLEppLu....s.hcplphLppElccp-sthpp-tcpLpchccsscttcsphccppcp......+.lLpt.ppssspp..tsppp...............tp.ssph.................-p-ltsllpplp......pclcshpsstt.......lpslpctlpcspst.....Ls	................................plhpphtp.h.hPstp.........................................cs.hsh-pl.lptppsLEppls....ss.culthLpp....Elc.ctptphpppptplppLcpsspshppphccppcch..................+plhph....s...pp.ss.p..hsthsppp........................................sssh.................ppElhslhtplp......pchcshpsstp.......hpshhphlpcshttLp.......................	0	14	34	62
+12936	PF13095	FTA2		Kinetochore Sim4 complex subunit FTA2	Coggill P	pcc	Wood V	Family	Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1 [1]. The equivalent higher eukaryotic protein is CENP-P. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2].	20.70	20.70	21.40	21.40	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.49	0.70	-4.73	13	63	2010-07-26 15:12:01	2010-07-26 16:12:01	1	2	35	0	56	62	2	191.60	25	60.04	CHANGED	Ms...........................h.p.L.hspPscpss...............stPpLchFht...Hs..............psIphlpalstss-..........uhVaphclpu+.pYALKl...h..asapss..hh.cltt+th.......hahs...PhssEsRAauRLspltcpGhh....AV+CHGWhhLo..cpphpph................sp.hphhspWAIVKD...alssph........s.pplsplhpchplh+cshlhspDlp.pNYRsuhlVDLGssh	.................................th..................................tPpLt.F.h...pt..............tslphlphLststp..........uhVa+sclpup.....YALKl.............a....htts.....t...phttp.h.............h.ahs..................PFssEsRAauRLpchscpsh.....AV+CaGah..hLs....c...pphp.h....................................tpttphhshhAIVKD...hlssth..................p.psh.c.lhpchphh++htlhstDlpspsYh.suhllDhups.....................................................................	0	3	27	48
+12937	PF13096	CENP-P	ShortName;	CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P	Coggill P	pcc	Wood V	Family	CENP-P is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2]. Fta7 is the equivalent component of the fission yeast Sim4 complex [1].	25.00	25.00	30.30	29.40	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.99	0.71	-4.96	5	51	2010-07-26 16:04:31	2010-07-26 17:04:31	1	1	35	0	27	49	0	127.20	51	60.61	CHANGED	Q+aRLuGsCpuLsFQLEFQlLElQsc-slssslTDLsIlhEssEapDLScFVSRsEEc+sLLLFFRSLpoFuEWCEaR+pTFcHFKEKYP-lVsLPEGspuEpMtlRNPQpPGhELlIVWKIHID-EG.sVlPlLDLLsKlPpQALELDcKuslEsuussFRoLLtlhGIEuoIEsLI	.....................+a+LSGsCp.lsFpLEFplLEh.psp-phSusloDLsIlhEssphuELScFloRsE-ctsLhhFFRuhp.asEWhcaRcpTF.HhKt.KYPphV.LscG.t.up.h.lpssp..sGFELhIVW+lplsE-G.pshPhLDLLsKhPppsLt.ppptsl-suP.tFRshlhhhGlEssl-pLI................	0	6	7	11
+12938	PF13097	CENP-U		CENP-A nucleosome associated complex (NAC) subunit	Coggill P	pcc	Wood V	Family	CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [1]. FTA4 is the equivalent component of the fission yeast Sim4 complex. 	19.50	19.50	19.50	19.50	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.18	0.71	-4.33	9	57	2010-07-26 16:13:52	2010-07-26 17:13:52	1	2	39	0	30	56	0	158.90	39	44.36	CHANGED	p-s-spcpVtssEp.......pspp.pshssss....thsEcPupsVTsppsuspsupsSstctss.AspoppcTQK..p...t+Rp+scptsptocsu-shplW...C.cth+tS..DIpELDVlLutFE+hhLEY+QclEScsC+pAIscFasplKcpLhchlcElQhLKsLK+KNsKlluslEKKRQRL	........................................s-sppcltssc+......hsspppcsh.sss.......phsEcPupsVssppsus.ss..psssEcpsh.....s.pspp.....csQKp......p.t.s++p+s....c..opshs.scs..S-.......ssplW...C.cshKpS..DIpEL-lVLstFEKhhhEY+QplES+sC+pAIspFasshKEpllchlpEsQhLKNLKRKNAKllusIpKKRQRL....................	0	3	7	13
+12939	PF13098	Thioredoxin_2		Thioredoxin-like domain	Bateman A	agb	Jackhmmer:O25140	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.89	0.71	-3.87	144	3289	2012-10-03 14:45:55	2010-07-26 17:16:55	1	21	1889	26	693	17334	6561	121.70	21	46.68	CHANGED	s..p..s..p...s...Kh.hlhhF.ssss.Cs..aCcp..hc.pplhp..sp...ltth......h....................pt.p..hth.hhl................sh...................t.....psp................t.........hht.....................ttt...............h......tpp.......................p..........................................hu..pph.s..........lpu.TPsllh.hs.t.p........G........p.......p....hs.G.hh.s.s.p.phh.phL	.......................................................ts....p..t+h.hlhVF.s.D..ss.C.s.YC.+c....h.c....p...p.h.t.s........st.......l.s.h.t...h...............................................p.....t....hhh....h..h.l.....................................ss...............................................................................t.......s.s.p........p.......tt..t............hps..............................................tttp..................................t.......................................p...................................................................................................Ls...p.ph...G.............................l...s.u...TPsl...lh...s................G............p.........h.......hs..G..h....s..s..pph.th............................................................................................................................................................	0	189	415	577
+12940	PF13099	DUF3944		Domain of unknown function (DUF3944)	Mistry J	jm14	Jackhmmer:O26108	Domain	This short domain is sometimes found N terminal to Pfam:PF03981.	21.70	21.70	22.30	28.00	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.32	0.72	-4.46	19	557	2010-07-27 11:58:35	2010-07-27 12:58:35	1	3	517	0	12	169	3	34.80	69	14.48	CHANGED	Y+.hDsDLEFLscCoscDLpsLVphLT+D.KDGphRh	..YL.pDsDLDFLQHCSEEQLAsFARLLTHN.EKGKsRL...	0	3	5	8
+12941	PF13100	OstA_2		OstA-like protein	Mistry J	jm14	Jackhmmer:O26089	Family	This is a family of OstA-like proteins that are related to  Pfam:PF03968.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.95	0.71	-4.90	30	372	2012-10-01 21:43:16	2010-07-27 14:41:27	1	9	305	0	104	461	481	129.20	26	25.21	CHANGED	Ko+VhL.HuDpLphDp.t.pPDAQlLhG...sVsh+HDushMaCDSAhhaEpoNSlEAFGNV+MpQGDTLhlYG-YLaYDGsTQlAhlR.cNVRMcN+ssTLhTDSLNYDRlhslGYYF-GGolsDpcNsLTScaGEYSPuTKhAlFspsV+LhNPcFsLsSD	...........................................................l...us.h.....hsp......s......s.....s.....h..h..G.....pVth..p.a.pu......hh..hsD....p...shh............p........p...p.....p..........hp...Ah..Gs.....V.p.....h......p....s..D.s.h...p.....lhu-hh.Yss..pp.s.hh....tp.V....h..h.h.p..p........t......p..L..h..s..-..pL.Ysph...p..h...uh......a.p.s.s..pl..h.s..p..t..s.hlh..u....p...G.Y..tsc...h..ts.h..p.t...................................................................................	0	41	89	102
+12942	PF13101	DUF3945		Protein of unknown function (DUF3945)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This is a C-terminal repeated region.	21.90	11.10	22.10	11.20	21.80	11.00	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.53	0.72	-4.67	53	731	2010-07-27 21:34:35	2010-07-27 22:34:35	1	9	130	0	73	590	11	54.20	26	21.58	CHANGED	chhssalslDctTNclhsh.........ss....p.......lpIP.......sclps.lcLosppppsLppGcslhlc.hhspcs	.......................................hlphD..Ttph..h.........ht....p...................ltlP.......pclpG.lcLosppppsLppGcslhlcshhscp..........	0	26	64	72
+12943	PF13102	Phage_int_SAM_5	DUF3946;	Phage integrase SAM-like domain	Ellrott K, Bateman A	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This family appears related to the N-terminal domain of phage integrases.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.17	60	914	2012-10-02 14:21:04	2010-07-27 22:57:47	1	2	196	1	136	888	67	145.40	17	38.17	CHANGED	lplRpKpL.ssGph.SLYLDhY...........suc.....RpaEaLplYlhsc.psttc.........................+cpNppslphAcsI+ucRhlElps.......pptsh.tspp.csctshl-ah...cphtcpppppsp.t........phpsshp.aLcpasttp.......lsFp-lDtcahpsFhcaLh	.............................................................................................................p.h.tpGph..slhl..chh..............................hptp..pph..h.t..lh.l..hsp..hstpp..........................................................pp.t.pp.h.h.t...ht.p..t..l.p.....t...p.chh.p.h.p............................tp.th...hp..p..t....ptp.......ts..hh....sah....cphhpphp....t.....p....s.p.......hp............papss...hp....p.....lppFhppp.........lshp-lshpalpsFcpaLh..........................	1	45	110	134
+12944	PF13103	TonB_2		TonB C terminal	Mistry J	jm14	Jackhmmer:O25752	Family	This family contains TonB members that are not captured by Pfam:PF03544.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.84	0.72	-3.94	102	1325	2012-10-03 21:09:15	2010-07-28 10:51:51	1	14	909	1	457	2915	858	85.30	19	30.22	CHANGED	hssYhspltptlpp.....p..W...s..st......ssshpshlplplss.sGp.l...shplhcsSGsptaDpuVtcAlp....pspshP..s....uth.....phthsF	........................................tahstltpplpp..........p.........a.....s.....ts............tstshp..s..plp......l..p........ls.s..sG.........p.l....h..s...s....pl...s.c.....o.S...G.....ssthD.....p.u.....shpulc........pssshP..s......tt......................................	0	136	268	371
+12945	PF13104	DUF3956		Protein of unknown function (DUF3956)	Aldam G, Mistry J	gba	Pfam-B_1228 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	22.20	22.20	23.90	93.00	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.12	0.72	-4.40	3	98	2010-07-28 10:22:01	2010-07-28 11:22:01	1	1	64	0	4	13	0	43.80	89	99.68	CHANGED	M..shssFVNGQPhLVVSVAGIEIARLEISLQVALTLIALGIPICA	..M-SCVlFVNGQPhLVlSVAGIEIARLElSLQVALsLhsLGIPICs.	1	0	2	2
+12946	PF13105	DUF3959		Protein of unknown function (DUF3959)	Aldam G, Mistry J	gba	Pfam-B_1424 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 260 amino acids in length.	25.00	25.00	25.40	25.30	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.67	0.70	-5.04	5	82	2010-07-28 10:32:12	2010-07-28 11:32:12	1	1	77	0	5	56	0	229.50	81	95.47	CHANGED	MLLSGLFPIAGIhKQIPLEQSLYIGGLLFFTSFGSYFAKKhYSRICSWIAYAPFITLLLlIWcQDITTuSlLANAKIAAC..IALlPsIaRFRTYGlTFGLlALWGALLWDlKEVQSLVILERMoSLMTScalYLLLLlGGLIlGGLLAshIHRKEKD-NKENINLapQKKKRK+LSFKI.LPRLPKL+MKLFKFGtK.oppK..c..+c+pYEEsh.....ch.pp.s.acpp..ol.GQTRMERRRN	..MLLSGLFPlAGlhKQIPLEQSlYIGGLLFFTSFGSYFAKKhYSRICSWIAYAPFITLLLVIWHQDISTSSIIANAKIAAC..lALIPCLFRFRTYGLThGLFuLWAALLWDhKEVQSLVILERMoSLMTSpahYIhLLlGGLIlGGLLAMhIHRKEKDsNKENINLFpQKKKRK+LSFKI.LPRLPKh+MKLFKFGGK.SKpKpPEKI+E+pYEEsss....TYEMpEQIc.YKE.s..slQGQTRMERRRN.............	0	0	3	3
+12947	PF13106	DUF3961		Domain of unknown function (DUF3961)	Aldam G, Mistry J	gba	Pfam-B_1483 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 40 amino acids in length.	25.00	25.00	63.10	63.00	21.50	19.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.95	0.72	-4.39	11	103	2010-07-28 10:37:55	2010-07-28 11:37:55	1	1	84	0	4	33	0	39.10	76	52.23	CHANGED	pslNcaFGI-tstSDpIWFYGhaululhlhhhsYllStll	.QSVNKFFGLD.TKEDCVWFYGFYGVAVSILLFMVFTSNIF..	0	0	2	2
+12948	PF13107	DUF3964		Protein of unknown function (DUF3964)	Aldam G, Mistry J	gba	Pfam-B_1516 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two conserved sequence motifs: FYF and AFW.	21.60	21.60	24.10	179.00	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.39	0.72	-3.81	4	117	2010-07-28 10:39:55	2010-07-28 11:39:55	1	1	117	0	4	44	0	107.70	71	96.81	CHANGED	TRpEpIhpLsFFEDKPtLAEQIL+lE+cEplaLPsQFEIKQsssYphGEKpsllGRlcpFYFlul.to.Espa+hQAFssEhcs+tFFlsLssIpcp.lAFWhNplELl	.TRQERILQLPFFENKRELAEQVLKhEREEHlYLPDQFEIKQVPPYSFGEKpuIIGRIHEFYFlSl.GS.EusWKYQLFKDEMKCREFFVpLPsIsDQQIAFWFNNIELL.	0	1	2	2
+12949	PF13108	DUF3969		Protein of unknown function (DUF3969)	Aldam G, Mistry J	gba	Pfam-B_1576 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	25.00	25.00	40.40	40.30	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.15	0.72	-4.39	9	294	2010-07-28 10:43:29	2010-07-28 11:43:29	1	1	290	0	11	74	0	100.10	49	88.47	CHANGED	htspppl-pahhhhhlGhhpuh+hshIols.hEthlFp.hhhcllpchslcccLl-IItpGhpLEDl........t.lhspcLpcsIcslpspslphLhphp.php..cptlphl.	........htp...LEKhhLhhhhGlhppLKLtllSlDpAc+hlFs..hhEhLtshulccsllDLIHpGsELEDh.............tshshoIE-hlslCLQhhcEh.pphcsVEhp.c.l.l.............	0	5	6	8
+12950	PF13109	AsmA_1		AsmA-like C-terminal region	Coggill P	pcc	Jackhammer-O25308 (H pylori)	Family	This family is similar to the C-terminal of the AsmA protein of E. coli.	22.50	22.50	22.70	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.24	0.70	-5.06	21	213	2012-10-03 05:41:17	2010-07-28 11:44:00	1	5	211	0	30	230	477	212.80	47	23.87	CHANGED	splpssupacsGphsh.hppsp..lplc..ucshsD-FlNplhs.....p.phhptGpFsl..p...u.t.s.s.s.shapGclplpsThl+shphlpNlluFIcTIPSLlsF+sPsFsscGaplcpGpllFthpc-hLslcslpLpGsShDIhGpGhIsLcspplslsLpLpTlKshoshIsKIPlls....YIlLGK-tpISTslplpGsLDsPchpTplspDlLhuPFsllKRll	.........................................................................................s.tlchcushtNAphslh.h.sssc...LpLp....s.p.N.h.s.DpaLNp.hLQ.....K.puVps....GlFsLp......h..t.G....s..s....chF.......cG..pl..cF..p..NTalKDL+sls.p.LISFI..s..T..........lPSLL...........hF.KsP.........sFN.p.KG.lsl+cG+l..lFst..KK....D..lLulpsIsLsGsSlDIhGhGohsL+hNslDhsLELKTLKohScsISKlP..IlN....YlIL.G...Ks...p.c..I.S.T.N.l.+lcGolDcPKh+T...........plloDsLpsPFNllKpIl...............................	0	10	25	29
+12951	PF13110	DUF3966		Protein of unknown function (DUF3966)	Aldam G, Mistry J	gba	Pfam-B_1525 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 86 amino acids in length.	25.00	25.00	111.50	110.90	18.80	17.40	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.50	0.72	-4.16	2	85	2010-07-28 10:46:03	2010-07-28 11:46:03	1	1	84	0	4	20	0	49.80	97	63.60	CHANGED	VIhYISRKFSQERpLEKSEITAEL-MLscEsaKKQKIKEDHEtsHHLNsp	.VIVYISRKFSQERELEKSEITAELEMLADESYKKQKIKEDHEASHHLNAN	0	0	2	2
+12952	PF13111	DUF3962		Protein of unknown function (DUF3962)	Aldam G, Mistry J	gba	Pfam-B_1505 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 233 and 796 amino acids in length. There is a conserved FSY sequence motif.	25.00	25.00	25.30	32.70	24.30	23.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.56	0.70	-4.95	5	80	2010-07-28 10:48:59	2010-07-28 11:48:59	1	2	78	0	5	63	0	214.20	84	34.62	CHANGED	QLLAFKslV-PLhpEsVaYlYFPcEWlsLLctHh+sacLssKLKtLNERLYhMFSDILFIQHNPYsLsEsoPWIVuKEPl+QEQLEYIs+uWY..ElIH-WK...PschlsPscLEWQsshISNLPlLHDNcTaaKWIPALITHlFCEcPLHLslsNcs-EElhFsPLRSQ+lsEAMSEPI+DccTQDYFSYVYRFEsITRGGE.NtPLLKVSIGIRRFYQp	................................................+LLTFENIVEPLLNEpVSFIYFPIEWLDIVEIHYKTFLLTSKLKRLNERLYDMFSDILFIQHNPYVLNENTPWIVSKEPIRpEQLDYIFQSWY....EIIHDWK...PNKLIEsPKYEWpYDLISNLsVLHDpEs....YSKWVPALISHIFCERPlpLE..NhNEE-IYFSPLRSQNICEAMSEP.....I...KDEKTQDYFuYVaRFEhITRGGE.NIPLLNVSIGIRRFYQE.	0	0	2	3
+12953	PF13112	DUF3965		Protein of unknown function (DUF3965)	Aldam G, Mistry J	gba	Pfam-B_1524 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 380 amino acids in length.	20.10	20.10	20.50	21.20	18.90	19.50	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.01	0.70	-5.25	3	85	2010-07-28 10:52:17	2010-07-28 11:52:17	1	2	83	0	3	38	1	284.80	92	75.80	CHANGED	QEIGWYKEAYTFMVs+sLssFVHTSlEYETWDlLTQAVAWNYLIIKYRIGcLEDuDlhIWERIKFNEECIEcCcsLLSHKEVLEFTFFYlCKQAKpLSKEcLNp-MMsLAIYCNTYVYDLYoYDLL+KYRKCTDFLSYYGPSpuVLACQRAVlAQISDRLNPLKTTHVDDYLYVMKEMMEHMoapFMcRY-HFIGKLLSYVPFFEMIQVPQHAYYCEELMYICKGIuYKEEILRNYlFIQLHDCLPSFIKlFLKNKRYATIHDILFYWCDcEQRMuLERKYNLSFIYEKYA	.......QEIGWYEEANsFMlsQGLAEFVHTSLEYETWDLLTQAVALNYLIIKYRIGELTDtDVEIWDRVKFNEKCITDCKHLLSHKEVLEFTFFYMCKRAKSLSKEQLNSDMMSLAMYCNTFVYDLYTaDLLRKYRKCTDFLSYYGPSQAVLACQRAVLSQISDRLDPLKTTHVDDYLYVMK-MMEHMTIGlMDRYsHFIGKLLSYVPFFEMIQVPQHAYYCEELLYICKGIcYKEEILRNYIF...IQLHDCLPSFFKLFLK..NKRYATIHDILFYWCDDE..QRMSLEKKYNLSFIYEKYA............	0	0	1	1
+12954	PF13113	DUF3970		Protein of unknown function (DUF3970)	Aldam G, Mistry J	gba	Pfam-B_1596 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved NPKY sequence motif.	21.10	21.10	21.10	21.50	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.85	0.72	-4.28	7	111	2010-07-28 10:55:07	2010-07-28 11:55:07	1	1	110	0	11	35	0	61.30	65	99.96	CHANGED	Mhp..lRlpGpcE.EI.chlpshsc..taEloa...spcshttsNPKYchSKslhsYlclKh.....pK	MIR..VRIEGTEE.EMLEFMcKMPDIPGFEKTH...hREPR.KGNNPKYDSSKNVLAYLSYKKIE..VANK.	0	2	6	7
+12955	PF13114	RecO_N_2		RecO N terminal	Mistry J	jm14	Jackhmmer:O25605	Family	This entry contains members that are not captured by  Pfam:PF11967.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.08	0.72	-4.26	24	198	2012-10-03 20:18:03	2010-07-28 14:46:01	1	3	198	0	22	850	192	71.10	66	34.33	CHANGED	MQGaILpsp+V+DEDLIVplLTpsplhphY.....RFYGARH......SsIplGaKIDFElEpst.ph.ls+LRslhHLGatWh	..........MQGFIL+TQK..VK..DEDLIVaILSPctL..lKsY......RF.....YGh.RH.........................SoIhsGYKIDF..t..LEcss..sF..LPRLKDVLHLGFlWI........................................	0	6	19	22
+12956	PF13115	YtkA		YtkA-like	Coggill P	pcc	Jackhammer_O25884	Family	\N	24.40	24.40	24.40	24.60	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.28	0.72	-3.63	90	656	2012-10-01 19:30:51	2010-07-28 15:05:13	1	14	358	0	179	609	32	85.10	22	36.73	CHANGED	ptpsps......hplpls.ssp...ph....psGp.s.s..l...hs....t...ss...psGc..sVs.sA.s.l.phphhhst.t..uhtph.pshh...........p.spp...tsGhYphp.ssh.sh....sGpWplplp	.......................................tshplplt.ss......h....psGcs.s..h...pl...........p...hs...pssc......sVs.cA.p..V...p.hphhps........Ghtph.pths.......................p.spp...tsGhYpsc.tsh.sh....sGsaplplp...............	0	58	121	145
+12957	PF13116	DUF3971		Protein of unknown function	Coggill P	pcc	Jackhammer_O25308 (H.pylori)	Family	Some members of this family are related to the AsmA family proteins.	22.50	22.50	22.50	22.60	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.69	0.70	-5.03	104	1538	2012-10-03 05:41:17	2010-07-28 16:08:13	1	12	1521	0	320	1280	259	286.00	26	24.21	CHANGED	htssspshc.YhPt..hhhupsLpsaLssAlp.......u.GpspsuplhapGslsp.aPat.....ppp..G.FpshsslcsuphpFpss..........WPslpslshslhFpNsslthpsspupltsss.hssspssIscl.sppsh...LpIcuchsu.pspsltchhppoPLhsslu..tsL.stlplsGplsupL.pLsIPLp.....st.......tspGphsl.pssslhls....shplpslsGplpFs.s.......sslsupslpAphhspPlslshss........ppptpshtl.....slslpGph....phptl.t......hst.....ltt...hlsGpssapsslslths...........ptshphpl	....................................................................s.ssspshR.YhP......hhucs.LhcaLssAlp........u...Gpscs..uplh.....h.t...G...s....pt...F.....Pap..........tsp.....GpF..plh..s..sl..csupa.tapss...............................................................W.Pulpslsh-Lsa....s.ss.....L......hh.....p.....ss......pu..............p.....l......s.....s......l.....p.....s.o.......s......l.............s..ss.............I.P..Dh.sccp.......LhIcuc.....hpG...sups.l.tsh...h.s.p..o.P...L.t..s.hu..ssL.sth..p...l.s.Gs.ls.u..cL.cLsIPLp.....................st...s....sspG.plsL...psssL.lt...s...s......sLpslsGp.hpFs..s........sslpup..slp..AphhstP..lslc.hss...........pp.tsp.shps........tl.slsush.......ps.tth.s.........hls.t.......l.p...hlsGsssaphpltlt...............................................................................................................	0	70	171	243
+12958	PF13117	Cag12		Cag pathogenicity island protein Cag12	Mistry J	jm14	Jackhmmer:P97245	Family	This is a Proteobacterial family of Cag pathogenicity island proteins.	25.00	25.00	26.20	25.90	21.70	19.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.41	0.71	-4.17	13	185	2010-07-28 15:30:54	2010-07-28 16:30:54	1	2	135	0	10	136	1	109.40	36	56.11	CHANGED	hhhshlLsuC.SSsPcPscl-tsp.tlslNsplhppp.hshVPKss.hlss.sWsYplhlpsh..c-chlssc.hsphFhlAHsuc+IlllGptsphtpYKpahppNGspusIp..lQP	......h.lLsllLoAC.Ss.sc.s.h.pcs+shpsl.Np.Ll-p..aSplPhss..plpshsahhplhl.sa...cDhllcsc.hslpFtLsHpo++IsllGcusphhpYKsYhptNGApusI-..lQ...................	0	2	5	9
+12959	PF13118	DUF3972		Protein of unknown function (DUF3972) 	Mistry J	jm14	Jackhmmer:O25162	Family	This is a Proteobacterial family of unknown function.  Some of the proteins in this family are annotated as being kinesin-like proteins.	22.70	22.70	22.70	23.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.49	0.71	-4.05	47	197	2010-07-28 16:11:16	2010-07-28 17:11:16	1	3	197	0	21	106	3	123.20	63	65.04	CHANGED	EFs+LspLsc-hlhthhspGtLpsKp.EcGKlhI-AspGT.ulV.sstpshhuMspshshht.s..FVEKTIGTILNLHEKVLsAKDETlpAlKNENpFLKDALhSMQElY-ED+KTI-hLppEL+pAR	..................EFCKLVHLsE-VVcuMhssGsLshKE.E-GKIYIEAppGT.h.........SVVPuu..spshsuM.......s.........sShslsupS..FVEKTIGTILNLHEKVLDAKDETL-ALKNENKFLKDALYSMQELYDEDRKTIETLspELK+AR...	0	8	18	21
+12960	PF13119	DUF3973		Domain of unknown function (DUF3973)	Aldam G, Mistry J	gba	Pfam-B_1636 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YCI sequence motif.	25.00	25.00	53.00	52.30	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-8.27	0.72	-4.03	3	87	2010-07-29 08:33:42	2010-07-29 09:33:42	1	1	86	0	4	44	0	41.00	92	51.35	CHANGED	MYYCIsCSEIHHEKusNDKVFKNGFYIDPFLGERYHLGMCK	MFYCINCSDIHHEKHPNDKVFKNGFYIDPFLGDRYHLGMCK.	0	0	2	2
+12961	PF13120	DUF3974		Domain of unknown function (DUF3974)	Aldam G, Mistry J	gba	Pfam-B_1643 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length.	25.00	25.00	38.30	38.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.86	0.71	-4.30	2	82	2010-07-29 08:38:48	2010-07-29 09:38:48	1	1	81	0	3	41	0	124.00	94	45.69	CHANGED	MuFIphVLLLlGTLLLIuFTlVVLlVYFGRKhYhSWsKPYKRAp-Sl-KLSNKShPFLQEFTQHPLFYRWIRTEGKKEQpshNTLFCsusQRTREQVFSMLPK-+QKKVHsMAKoTKKlTNE..DI	MSFIQTVLLLLGTLLLIAFTVVVLVVYFGRKLYFSWTKPYKRApDSL-KLSNKSlPFLQEFTQHPLFYRWIRTEGKKEQ+TLNTLFCASuQRTREQVFSMLPKEKQKKVHVMAKTTKKLTNEDIDV....	0	0	1	1
+12962	PF13121	DUF3976		Domain of unknown function (DUF3976)	Aldam G, Mistry J	gba	Pfam-B_1743 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.	25.00	25.00	83.50	83.00	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.02	0.72	-4.11	3	82	2010-07-29 08:43:40	2010-07-29 09:43:40	1	1	82	0	3	20	0	40.00	94	67.13	CHANGED	MYLFVRKDITKDNTLTKRGFYKLIGCLVVMFIGIIVMIVLl	VFLFIRKDV.QGGTLTKRGFYKMIGCLVVMFIAIIVMIVLI	0	0	1	1
+12963	PF13122	DUF3977		Protein of unknown function (DUF3977)	Aldam G, Mistry J	gba	Pfam-B_1744 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	61.30	61.20	20.00	17.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.67	0.72	-4.17	4	85	2010-07-29 08:51:07	2010-07-29 09:51:07	1	1	85	0	2	40	0	76.40	87	91.52	CHANGED	MKYIEhGIGN+WhVRTETEpEDGTEFEQKGIlKPIYFESlYlRlWFRKTClIhDoKEGFKKh+KpRsEYKFIhGIVS	.MKYIEIGhGNRWFVRTETENKDGTEFEERGIIKPIYFESLYVRlWFRKTChIFDTKEGFKKVKKRRIEYKFIlGIVS	0	0	1	1
+12964	PF13123	DUF3978		Protein of unknown function (DUF3978)	Aldam G, Mistry J	gba	Pfam-B_1745 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.	25.00	25.00	27.00	26.70	19.00	17.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.72	0.71	-4.80	3	84	2010-07-29 08:52:49	2010-07-29 09:52:49	1	1	83	0	4	30	0	143.90	88	98.04	CHANGED	MEAYNMHNFINTNIESpPcETsFNLHICEoNEFDsNLTKSTTLSFIVTK+NIKIlTKKWINScpESMIGKSYIIPTKAFHYlLPIIsEoEEEMsIQVQSFGlsGELLLNERLLIcKNN+hNS.KIsuFFEALNENI+QALRTLQIp	.......MEAYKMHDFINTNVESHQNETVF.NLcICE.TsEFDVSLTKSTTLSFIVSKKNIKIVTKKWINSNQESMIGKSYIIPTKAFHYFLPIISETEDELNIQVQSFGLHGELLLNERLLIDKNNKHNu..KIToFFETLDENVNKsLRGLQI.H....	0	0	2	2
+12965	PF13124	DUF3963		Protein of unknown function (DUF3963)	Aldam G, Mistry J	gba	Pfam-B_1512 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 85 amino acids in length. There is a conserved DIQKW sequence motif.	25.00	25.00	84.10	84.10	18.40	17.50	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.98	0.72	-4.16	4	53	2010-07-29 08:58:40	2010-07-29 09:58:40	1	1	51	0	2	29	0	40.00	86	64.97	CHANGED	MlhINshFIERYFcDIQKWIRNIThCFALLVVsLVuLWIG	MLSIYTAFIEKYFcDIQKWIRNITFCFALLVVVLVALWIG.	0	0	1	1
+12966	PF13125	DUF3958		Protein of unknown function (DUF3958)	Aldam G, Mistry J	gba	Pfam-B_1404 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There are two conserved sequence motifs: RLF and TWH.	22.80	22.80	24.30	24.20	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.42	0.72	-4.11	9	95	2010-07-29 09:08:48	2010-07-29 10:08:48	1	1	45	0	3	73	0	92.20	64	82.10	CHANGED	VFEEQDRNQpAIQpQEpAEtDFaEh+sRssRLFsRILETWHsDKElSpFFhNhpQEuQaIERKLTFELENQKETLlKE+RcLpDLENDLoYppQpLt+E	...............................lFEEQscNp.AlQtQEpAEAsFaEW+sRspRLFsRILpTWHGD+EhspFFhNhhQEspplERKlTFELENpKETLLKE+RcLS-hENDLSYpQQ.QLtRE.......	0	0	0	1
+12967	PF13126	DUF3975		Protein of unknown function (DUF3975)	Aldam G, Mistry J	gba	Pfam-B_1736 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	25.00	25.00	43.10	43.00	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.04	0.72	-3.83	2	81	2010-07-29 09:50:29	2010-07-29 10:50:29	1	1	81	0	2	42	0	78.80	90	93.89	CHANGED	MWKEKGpQllshIhlGIVlLLQhSFHhIE.LFHKslSILTFhPNMsLEllSIVWSIIASIhIlIIW.....uIthLhpplhhKcS	MWKEKGKQlLAWITLGIVILLQISFHIIEWLFHKVlSILTFLPNMTLEhISIVWSIIASIAIVIIW.....SIAKLWNKLFKKDS	0	0	1	1
+12968	PF13127	DUF3955		Protein of unknown function (DUF3955)	Aldam G, Mistry J	gba	Pfam-B_966 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 68 and 87 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.	20.60	20.60	22.50	22.20	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.88	0.72	-4.43	30	317	2010-07-29 10:35:54	2010-07-29 11:35:54	1	6	248	0	29	152	36	61.90	33	75.10	CHANGED	hppahluhlhhl.lGlhChhhashhsShVsssGhLpEP.FaLIPlualhlhhu....llshlhshlp.ph	.......hpphhluhhhhl.hullhhhIpshs.ohlsssGhLcEP.hF...ahlPlGalhllhu....hhshlhshlpp.h........	0	13	21	25
+12969	PF13128	DUF3954		Protein of unknown function (DUF3954)	Aldam G, Mistry J	gba	Pfam-B_934 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length.	22.20	22.20	22.60	22.80	21.60	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.33	0.72	-4.54	12	144	2010-07-29 10:39:09	2010-07-29 11:39:09	1	1	89	0	4	82	0	48.70	54	84.47	CHANGED	MK+.EIshtpNtlYlV.pcGclphl.pPPpoGFGEQslhWpsGKVs+scsppT	......MKt.EIDlppNtIYlV.KNGpVphl.pPPtoGFGEQshsWpsGKVsRs-sphT..........	0	1	3	3
+12970	PF13129	DUF3953		Protein of unknown function (DUF3953)	Aldam G, Mistry J	gba	Pfam-B_875 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 76 amino acids in length.	21.80	21.80	21.80	22.10	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.76	0.72	-4.33	36	454	2010-07-29 10:41:40	2010-07-29 11:41:40	1	1	294	0	22	219	1	41.90	39	68.35	CHANGED	hhhhL...GhhhlhhGlp-h+...ccc....KshGhhshlsuhaslhVul.p	........hLL.GlhslpIGhpphK.....Kcc........KhhuIlshLAGshlllVulh.....	0	5	13	13
+12971	PF13130	DUF3952		Domain of unknown function (DUF3952)	Aldam G, Mistry J	gba	Pfam-B_704 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length. There is a conserved VMSAS sequence motif.	25.00	25.00	52.60	52.10	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.35	0.72	-4.07	19	114	2010-07-29 10:44:54	2010-07-29 11:44:54	1	1	37	0	2	107	0	104.40	60	41.53	CHANGED	usLLSGCuFGE......TKIEYERhVKALDEGDMKTVMSASDDGYAaVcEcsI....aSsaEcKEDGpHp+slYQTT-GlYNhK-KsLYGpToQplsoclcsccp+cp.psYKcEpl	.....SLLSGCuFGE......TKIEYE.hVKALDEGDMKpVMSASDDGYAYVKpcsI.....STaEpKEDGcHppsIYQTTcGlYNsK-KsLYGpToQclsoslcsccp+cc..sY+pp................	0	0	0	0
+12972	PF13131	DUF3951		Protein of unknown function (DUF3951)	Aldam G, Mistry J	gba	Pfam-B_698 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 56 and 71 amino acids in length. There is a conserved YTP sequence motif.	25.00	25.00	39.60	39.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.69	0.72	-4.19	4	137	2010-07-29 10:49:09	2010-07-29 11:49:09	1	1	86	0	5	52	0	50.70	61	82.10	CHANGED	MILhTIGhlLhTlFIFFIIGFlTFpMFVsKATPQIYYTPC-shTsQohpctpp	...hlLhTIG.l.LTlhIhhIIGF..ahhFlcKto.p...aYTPh-slTspohuca+.c	0	0	2	2
+12973	PF13132	DUF3950		Domain of unknown function (DUF3950)	Aldam G, Mistry J	gba	Pfam-B_688 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 30 amino acids in length. There is a conserved NFS sequence motif.	25.00	25.00	36.80	36.30	23.60	23.00	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.39	0.72	-4.42	8	501	2010-07-29 10:51:02	2010-07-29 11:51:02	1	1	257	0	7	125	0	30.00	81	50.68	CHANGED	LL-QIstuhtpEp....ouNFSAWVh-ACRcKLp	.MIEQINIAL-pKG....SGNFSAWVIEACRRRL..	0	2	2	7
+12974	PF13133	DUF3949		Protein of unknown function (DUF3949)	Aldam G, Mistry J	gba	Pfam-B_636 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 69 and 87 amino acids in length.	25.00	25.00	61.30	61.10	17.30	17.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.04	0.72	-3.75	5	147	2010-07-29 10:52:29	2010-07-29 11:52:29	1	1	88	0	5	77	0	60.90	70	78.40	CHANGED	MIPIQYtYIcuLK...Ec++KpGlSQcELY-NMSFEEEQLHYHsQGNlFsIPuuhVAShIY+lKp	.hlPIQY.YlphL+...EKpKKhulSQpELY-pMSatEpQlHaHhQuNsFsIPuuhVA.hIhKVK..	0	0	3	3
+12975	PF13134	DUF3948		Protein of unknown function (DUF3948)	Aldam G, Mistry J	gba	Pfam-B_550 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	25.00	25.00	51.80	51.60	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.47	0.72	-4.48	8	175	2010-07-29 10:54:03	2010-07-29 11:54:03	1	1	80	0	13	52	0	34.70	69	93.11	CHANGED	MpN.cQVLQVTKhDFLGSASGAslLTAhIVFLusVL	...Mps..EQVLQVTKsDhlGShuGAVVLTuhIlFLusVL	0	0	4	4
+12976	PF13135	DUF3947		Protein of unknown function (DUF3947)	Aldam G, Mistry J	gba	Pfam-B_493 (release 24.0)	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	26.90	26.90	21.60	19.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.97	0.72	-3.78	13	175	2010-07-29 10:55:40	2010-07-29 11:55:40	1	1	80	0	4	91	0	77.00	55	98.40	CHANGED	hssYa.sphplt.......suIThuuAQuTlpAVpQAhQ.....MQQQh..th..p.......uh..aYsshtY.......hYPs........sFoTIPaGssY.L	.........h.pYFhstttht.......suIThuGAQuTlpAV.pQAlQ.....MQQQhQ.....Q.......G....YSph.h.......hYPs........oFhoIPYGusY.L..........................	0	0	3	3
+12977	PF13136	DUF3984		Protein of unknown function (DUF3984)	Aldam G, Mistry J	gba	Pfam-B_3236 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 393 and 442 amino acids in length.	21.30	21.30	40.40	30.50	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.36	0.70	-5.21	20	72	2010-07-29 12:40:09	2010-07-29 13:40:09	1	2	68	0	59	69	0	298.50	34	77.17	CHANGED	RSRRSasSLpHlSLAPLTsRFPlDDDss..........s.tst....t.hstsspsspTSYLuShSVPsTPslL..ScSRssSpsRtp.....p+ppoopptphS-.....osLcupsstpshHHppp.............pcptpppsssst............p.ss.tppc.pDsEWLLRAGlALASSTREEKGQSWLVKR-SSTSLV..................uEss.s..ptht+ppc............tppptoRRuR......................SGhSTP...sAhSRRsSpSRsuSRtu.SRs-L..sMTuhch............sttsttths...ss..p-sp...thlPDFVDcclRsEMt.h................tp.cp..........s.............st....u-sDsE-.......-.hDEtEhQRLTRc.cGhGLGuWI.DRlVEWTLFuVE-	.............RppRS.ssLpHlSLAPLTs+hPl-D-s..............................thtsh..poSYLpuhSsPsTPs..lL..Sp..Stssupsphp.......tpss.tt.hSp.......o.h.puhsss..p.hppppt......................pt.tppphspt..........................p....shsppc.tDs-WLLRsGhsLuSpsREpKGQSWLVpRpSS.TSLl.....................spsp.s....cthtcppc......................tspptuRRup.........................Ssh....uoP...hshSRhs....S+s.sS+....hu.SRspL......MTshph.........................tt................psh...hhsPDFV-.s.+.Eh.......................................................................t-p-spp...-..DEtclpRLsRc.pshG..lGuWl.-plltWoLFuVE-...................................................................................	0	12	27	46
+12978	PF13137	DUF3983		Protein of unknown function (DUF3983)	Aldam G, Mistry J	gba	Pfam-B_2658 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 40 amino acids in length. There is a conserved AWRN sequence motif.	25.00	25.00	39.50	39.50	19.90	18.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.56	0.72	-4.27	15	83	2010-07-29 12:42:07	2010-07-29 13:42:07	1	1	55	0	3	48	0	34.70	68	79.89	CHANGED	KK+Kl+KAIsRRuKsl...EK.cRVcpAWRNIFVQAGI	.KK+KlRKAIARRsKsV...EK.aQVsKAWRNIFVQuGI.	0	0	2	2
+12979	PF13138	DUF3982		Protein of unknown function (DUF3982)	Aldam G, Mistry J	gba	Pfam-B_2022 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 73 amino acids in length. There are two conserved sequence motifs: EKL and EIP.	25.00	25.00	34.50	33.60	19.40	17.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.28	0.72	-4.09	20	72	2010-07-29 12:45:00	2010-07-29 13:45:00	1	1	40	0	0	43	0	54.10	58	87.08	CHANGED	M.....hGI.IshtVshTEIlAPAsNVSIVVNESESPI+hEEKLSVATAPLIEIPTPsGAHPGAVV-hDTLIT	.......hGI.IshtVshTEhhsPAspVoIV.pEot.PIph.EKLpVushPh.EIPsPsGtcPGtVV-h-pLIo	0	0	0	0
+12980	PF13139	DUF3981		Domain of unknown function (DUF3981)	Aldam G, Mistry J	gba	Pfam-B_1754 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.	25.00	25.00	186.40	185.60	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.41	0.71	-4.09	2	80	2010-07-29 12:48:28	2010-07-29 13:48:28	1	1	79	0	3	48	0	114.00	96	19.90	CHANGED	hIPWTRuuptLRsVDKcGscKVlKtKpusILhIPlLhWIGIAIYEYhWLIDDRVDSIlTHYSVslAlLIGlVLhSQsphG+LEspLKullMhILLsSYGYFGYLHDIVISQKKY	LIPWTR.SGSKLRAVDKKGDEKVVKGKKSSILVIPVLFWIGIAIYEYFWLIDDRADSILTHYSVAVAILIGLVLFSQDQIGKLEGTLKGLLMFVLLASYGYFGYLHDIVISQpKY	0	0	2	2
+12981	PF13140	DUF3980		Domain of unknown function (DUF3980)	Aldam G, Mistry J	gba	Pfam-B_1748 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length.	25.00	25.00	77.20	77.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.06	0.72	-3.71	3	79	2010-07-29 12:54:34	2010-07-29 13:54:34	1	1	79	0	2	48	0	86.60	85	67.47	CHANGED	MEQEQTSYLSIKILKIMSVIYLIVSILsAlSTGuFIpss..GFs.uISlSGoG.uAlGllhLGSIFQSVLVFCGIWVFILLVETVIKIYEK	.VEccQTSYLSIKILKIMSVIYLIGSILMAFSTGPFIHNl..GFD.EISISGSELGLISIVMLGSIFQSVLVFCGIWVFILLVETVIKIYEK	0	0	1	1
+12982	PF13141	DUF3979		Protein of unknown function (DUF3979)	Aldam G, Mistry J	gba	Pfam-B_1747 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	22.50	22.50	24.50	216.30	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.38	0.71	-4.19	3	81	2010-07-29 12:55:49	2010-07-29 13:55:49	1	1	81	0	3	37	6	113.70	90	95.87	CHANGED	hoLFQsAPhEDtKGGWKYIIQEQNGKYpIsN-IussHMSVELYFNEYDElRITLYKDGpPITTMQRIsIlKlELEEDEEGIQFVLERMPSRMIRLQLKPYLAlEMGLYWEVCED	.MTLFQAAPKE-sRGGWKYIIQEpNDKYEIVDEMLKNQMSVELYFNEYDEVKITLYK-GhPIoTMQRIAISKVELDEEEEGIQFVLERMPSRMIRLQLKPYLALEMGPYWEVCDD	0	0	1	1
+12983	PF13142	DUF3960		Domain of unknown function (DUF3960)	Aldam G, Mistry J	gba	Pfam-B_1431 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 72 and 89 amino acids in length.	21.50	21.50	22.10	22.60	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.98	0.72	-4.21	4	84	2010-07-29 12:59:48	2010-07-29 13:59:48	1	2	82	0	3	37	0	88.60	94	23.50	CHANGED	MhAsp..PNWsLVhDsYhEPNNFADLFSLLVPs+PKGEuKERTILsWKEKEFYKEENLhPFILYGMNKuK-LPQFHKDEIPTLVRIVRL	......MKAVQtDPNWNLVTDTYIEPNNFAELFSLLVPCHPKGEGKERTILVWKEKEFYKEENLAAFIVYGMNKAKNLPQFHKDEIPTLVRILRL.	0	0	1	1
+12984	PF13143	DUF3986		Protein of unknown function (DUF3986)	Aldam G, Mistry J	gba	Pfam-B_362 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	20.30	20.30	22.30	22.30	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.11	0.72	-3.53	12	206	2010-07-29 13:04:43	2010-07-29 14:04:43	1	1	96	0	12	100	1	86.80	50	91.36	CHANGED	hpaDsspHLHlGYY-cshDl...EulAYKphscslWslahsatthshhhpph.pth...hh-thGhpl..aolcspDLs.-tusthFEcWLhcNp	......cYDsShHhHlsYatsthD..l...EshAYKRhNEsVWDlYhsahthss..hcclEpt+.....h.-.hGhhV..aSlcspDl..s..E.upt.FEcWlh+Np.......	0	1	6	8
+12985	PF13144	SAF_2		SAF-like	Coggill P	pcc	Jackhammer:O26012	Family	The members of this family are similar to those in the SAF family, and include flagellar basal-body proteins and pilus-assembly proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.97	0.71	-4.82	119	1927	2012-10-01 20:51:14	2010-07-29 14:46:06	1	4	1667	0	431	1918	464	178.10	24	76.94	CHANGED	lpptlpp....hlppp...hsth........ph.........plpshplc.....s.php..hss....s....ps.hp.....h.plss...spt.tspsslpl....p....s.p..........ssp...sa...p..lalssplph....h....sphl............VAs+sLs+GphlsssDlshpphslsplt.s.shh..s...-..p..llGtps+RslpsGpslptsplt.shlVp+GppVplhAps.suhplpspGpALpsGshG-pl+V+N.pSs+llsupVpusGpVcV	........................................................................h......t.h.tp........h............p.....h.....hp................hs....s...p........ht..ss....ss.t....h...up...h..s..h.....h....p....s................s....p....haltsplp.s............p...ts.hl..................................Vuspsls.+..Gphlss....s.slp..hcp......hcl.s.p...ls..p..shl...s....hs........p...ll..st..h......ut..+.s.lssspslphstlpp..shhVptG.pp..V.lls.ps.suhslsspGpALpsushuppl+V+.....sSs....p..l....lpuhVsu.sGpl...............................................	1	114	243	333
+12986	PF13145	Rotamase_2		PPIC-type PPIASE domain	Bateman A	agb	Jackhmmer:O25628	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.39	0.71	-3.48	206	2673	2012-10-02 13:30:10	2010-07-29 16:26:11	1	27	2057	2	569	6738	2215	123.40	20	28.69	CHANGED	l....s-..p-lcphYc....p..pts..pa....t.ps.pt...p.h.hp.........hhh.hs...sp....st.s...p..tt.....tpt.....hpt..t.........sh...pp.h..ts..h.tp..t..p..shs......hps..hs...........htp.ts.....................p...hst..................................t.htptl..h...sh.....ps..G..p....h.s..s.s..l.......ps..st......u.h..hlh+lssh.p.s..sp.shs.h-..c..s..+.s	.............................................................................................................................................................o-t-lpphY-..............p....pps....pa................t..t....pt...h.t.hp...................hlt..hp............sc.........sp..A.........c....ts..............hpp.........hpt.t...............................t.......ts.F...ss...l..uc...c.....p...uss...............sss..hs................hhp.ts.............................................s..lPt.....................................p.ltp..As...h.......p.h..........cp..G..p.....l.S..s..s....l........ps..ss...........u..a.hll+lsch.p..s...tp..sts.hpcs+..........................................	0	194	373	478
+12987	PF13146	TRL		TRL-like protein family	Bateman A	agb	Jackhmmer:O87326	Domain	This family includes the Swiss:O87326 TRL protein that is found in a locus that includes several tRNAs.  The function of this protein is not known [1]. The proteins in this family usually have a lipoprotein attachment site at their N-terminus.	25.00	25.00	27.90	26.10	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.31	0.72	-4.00	22	210	2010-07-29 16:26:30	2010-07-29 17:26:30	1	1	172	0	33	102	11	77.10	51	73.76	CHANGED	sGhlaspsshPstss.......sspssKpGcACspo..lLslVuh.GDuSl-sAtcpusIsclspl.....Dapspshl..slasphCslVpGp	.........................u.huLYTcVpsPlouT.......slsuoKoGKACApo.....VLGlVsT..GDASI-oAK....KuGcIShVoSV.....DYETTGsa...sh..YGKsCVVV+Gp.	0	9	26	27
+12988	PF13147	Amidohydro_4		Amidohydrolase	Bateman A	agb	Jackhmmer:O25045	Domain	This family of enzymes are a part of a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.94	0.70	-4.37	111	10639	2012-10-03 00:45:34	2010-07-29 18:01:37	1	79	4086	62	2860	18795	7896	309.00	16	70.36	CHANGED	Dsp...G.thlh..PGhlDhHs+.....................hstthsst.ht.hh.........tuhhshh............tsshpssthttthtp........................................hhh.sththtsttthhtthpphhthhtttshsh.th...............................thttsthtthhp...tstpts.hhhhhsttstt.........tt.httththhthh........................hthstshplhpthssthshththhttttsthh.t.............hthstttslssssht.......hhp.h.th................shthhhhssh..................tptshtsltphhpsG...hhhhluoDth.........................sssshhtthhhhhht...hshs........pslphsotssuphhsh........tphGtl..t.GtpAchl	........................................................................................................................................................................................................................................................................................................DspG.thlh....PGhlD.hHsH...............................................................h..t.t.s.s.h...h..h.p....s..h.................................h........t..h.suGhoshhp...............................hssspsthh.ttth.hp.h.................................................................................................................................................hhh.h.h..t..h..h..h..t...t.........h..h...t......th..p...p...h.t....t....h....h..t.......h..t...h...h...s.h....t..h..............................................................................hh.sst..h..h.t.hht..............tt..........t.ths................................hhhh..t.tp..t.......................................t.h.h..ttt..t.h.hh.................................................................sts..hp..h..h..h..h....h..t..t....t.......h....s....h...th.ph....htt..ph.st.......t.ht.................................hths..cttulssst.t.....................................................hhtpth.th...........................................sshhhh..sPsht................................................pppshtsl.h.......p..h.lp.sG.................shs.s.lu..oDa.ssts....................................................................................shts.hl.hh..h.t.hhht....................htl.oh......t...............................phlph..h.o.ts.sA.c.hhsh..........................tptGpl.......tsGtpADls.........................................................................................................................................................................................................................................	0	927	1826	2398
+12989	PF13148	DUF3987		Protein of unknown function (DUF3987)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	27.00	27.00	27.00	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.88	0.70	-5.90	117	899	2010-07-29 17:03:48	2010-07-29 18:03:48	1	19	543	0	189	834	169	314.80	20	61.84	CHANGED	ppspsshshhshusLsslusshtst.sclph....sshht..sssLahhslupuGpt.Kosstphhhtslpphcpphtpphppphppactpt....th..hphctpshcpphtt...t......................ttppPphP......t.pllss-sTspulhptLtpsss.shhlhssEusshhsuhs.h......phhpphshhpcsacGss.lshsRpspsp..ht.lpp..spLolhlssQPshl.phlhthps..hpspGhhuRhL...hshPsstttp...c............shsp....tthpsatpclpplhpt...............tttp.hhlphoscAppha.phasplcpch.t.suph.....hpshsuKhsttssRlAullphhc..............................................ttstpIss-shptAlp.lscahhpcutclhs.hhsssp	..................................................................t....h..shhhhuhLsshuh..shts..........hplth.....sshht.sssLahhhlu.supt.Kos.h.t.h.h.h.t...........hh.hcpthhpphtptht.t.aptt.......hp.p.tth.pt........................................tpts...P.....hhhhlhs.s.sT.pulhp........h...tps.t...shhlhp.sEhss.lhsshs...........pt...sh....hpphas.......Gs.....s...lshsR...ps...pst.....hh..lp.p....splolhhhhQPshh.phhhptps.........sp.....GhhuRhL...hshP.s..s...tphh..p...................................p.....thhptht...p.phpclhph.h..........................................ttp.hs..lpho.sp.Appha.ph..hp.p..ltpch.t.....s.......hps.hhs.+h.st.hhRlAhlhthhp....................................................tph...Is.pshptAht.ls.p.ahh.p.chhhl.s......t............................................................................................	0	73	131	165
+12990	PF13149	DUF3988		Protein of unknown function (DUF3988)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	29.90	29.90	29.90	29.90	29.20	29.80	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.44	0.70	-4.89	252	1094	2010-07-29 20:05:34	2010-07-29 21:05:34	1	66	98	7	150	1009	2	288.40	14	64.34	CHANGED	hhlsuCspsc......................t.t.stststs..........lplsss..................ststTRusss..............tts....-plG........lash..............................t.ssshsstthhsshhhhtss..............stshssss.thaa........s.spphsh.hA....Ya......P.........hpssssss........ht...ssssp......................t......................Dh....lhApsps.........sssssshs........................tFpHthopl.plplp.t..ssshsst.....hh....plpshtsp.................ushs.....h.....sGshsssss............................ssshshts...sssshsh...........hhll..P.......................tsst.........hplphshssp......stphhhsstttt..........................sGppasas.........lslsps...........hhhsssslssWss	..................................................................................................................................hhsuCspcp........................t.....tstpts...............l.phsss.....................ssstTRusss............thpss..........cplG...............lash.................................ts.sst.hhssh.hh.h.tss..........................................shshssss...hha.........s.ssph.sh..hA.............Ya..........P.........................asssssss............shs...hs..........hsspp...................................t......................Dh........hhupsps.....................tsssssls.....................................h.....pF..pHthopl.plplp.s...ssshsss.......................h....hplps..h..tsp...................................ushs...............hs.........sGshsssss..................................................s.sshshtt......sssstsht..................hllh.....P......................tsss...........................hpl.phsh..sst......................shthhhsttth...........................................sGppaths.lplstt......................t.ph..W......................................................................................................................................................	0	23	126	150
+12991	PF13150	DUF3989		Protein of unknown function (DUF3989)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	27.00	27.00	27.00	27.30	26.40	26.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.60	0.72	-4.53	17	195	2010-07-29 20:28:02	2010-07-29 21:28:02	1	1	80	0	16	135	3	83.90	32	85.32	CHANGED	+phlcthpcth-scLRthhstLsPctRlhllLshhshFusLulYhhssuIacl....G+p-tpphpIcHIcpl-L....pp-ohNhhp.hp	............h.hlpchpchhss+L+thhstLsPcpRhtllLsMhshFusLulYhhspulYcI....G+..p-G.pc..hphcHltplcL.........s-ohp.hp....................................	0	4	14	16
+12992	PF13151	DUF3990		Protein of unknown function (DUF3990)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	27.00	27.00	27.10	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.86	0.71	-4.84	47	384	2010-07-29 21:37:02	2010-07-29 22:37:02	1	9	247	0	57	326	11	140.90	29	74.19	CHANGED	hhLYHGSsphlc.pPclttu+.ppDFGpGFYsTp.h-QApcWApph...........tpsshlNhYpl-hsthp...LclhcFp.thspcWLsFlhpsRpstt....................csYDllhGshADD.phashlptahsstIoh-thhctL+htp..spQhshpop+Als.pL+ah	...........................hlYHG....S......s.....h.......l.....c......p.......P..ph.ths.......+...p..h..DF...G....p....GFYhTs.hcQApcWAtph...........................ttpshls..hYphs......phh.......hphhhF........p.....ths.cWlpFlhpsRpt..pt....................ppYDllhGs..hAsD...phh...phlp.ahp...s.......h...........l.......sh...c....p...hhpthp..htp......spQhshtoppshp.hLph.h................................................	0	28	42	49
+12993	PF13152	DUF3967		Protein of unknown function (DUF3967)	Aldam G, Mistry J	gba	Pfam-B_1529 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 249 amino acids in length.	21.60	21.60	21.60	22.20	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.43	0.72	-4.31	15	228	2010-07-30 08:43:20	2010-07-30 09:43:20	1	2	107	0	8	152	0	35.30	50	17.38	CHANGED	RtppRDppLMpsIRElQEoK+LIAAScpK..hpFW	...+.ppRDppLMpsIREIQETKR....h.......lA....Ao..KE...p...p..hhp.a................	0	1	3	3
+12994	PF13153	DUF3985		Protein of unknown function (DUF3985)	Aldam G, Mistry J	gba	Pfam-B_3329 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	25.00	25.00	82.80	82.60	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.38	0.72	-4.15	8	55	2010-07-30 08:48:10	2010-07-30 09:48:10	1	1	55	0	2	11	0	44.00	94	95.65	CHANGED	MEILoIILIVLLIYVVFKVAYVALKILAILLIIFLIVEFGSKLL	MEILTIILIVLLIYVVFKVAYVALKILAILLlIFLIVEhGSKLL	0	0	1	1
+12995	PF13154	DUF3991		Protein of unknown function (DUF3991)	Coggill P	pcc	Jackhammer:O25192	Family	This family of proteins is often associated with family Toprim, Pfam:PF01751.	22.20	22.20	22.20	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.75	0.72	-3.79	113	763	2010-07-30 16:16:39	2010-07-30 17:16:39	1	15	512	0	102	654	29	82.50	24	16.66	CHANGED	sYLpppRtlstpllpthhp.....pshlhp.........sph............t......Nhl........FsttD.............p.pGpspGhphRGs...................ttsa.+uhspG.......sshhashsh.........sps	.............tYLpppRslsppllpthhp.....pshlhp.........sph................p..................sll........Fhth-.....................ppsphtuuphpGh....................ptsa.KthspG.....sshthuhsh.......s..........................	0	36	72	92
+12996	PF13155	Toprim_2		Toprim-like	Coggill P	pcc	Jackhammer:O25192	Family	This is a family or Toprim-like proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.64	0.72	-3.67	328	1811	2012-10-01 21:47:57	2010-07-30 17:17:53	1	42	948	0	254	5018	2583	95.50	22	20.72	CHANGED	hlhEuhhDslShhp....hthps...................slushGsshp.........pthphL..pph...tp............lllshDsD...........pAGppAsp+hh..phhtp.....................hphphhphstt.c.....D...hs.........-hl	.......................................hlhEuhhDhlSahp......lthpp..t..........................lsl.susu..s..h....t..............................phhphL.....pth........pp......................................lhhs.hDsD.............cAGccsspclt.....pthttt...............................................psth.h.h.tt..K......DhN-hL..............................................	0	97	201	234
+12997	PF13156	Mrr_cat_2		Restriction endonuclease	Coggill P	pcc	manual	Family	Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2]	22.00	22.00	22.10	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.61	0.71	-4.24	8	260	2012-10-11 20:44:47	2010-08-02 13:31:32	1	15	227	0	57	253	94	120.90	35	9.82	CHANGED	csDPshpspYscVpTas-WAc..pGhsppDTGIDLVA+hRcsDuasAIQCKFYsssHpIpKsDIDSFhsASGK........c.FopRlIlsTTc.cWScNAEshLcsQplPlsRIsLscLEpSpIDWstats+ucllLp	.............................-Phhtppa.c.pVahWtD......Ws..........p.....t..s.....pp..DsGIDL.VAp..pp..s..........s...s.p.......a..hAIQCKFY....pss..t..pltK.s-.IDSF..hs....s....SG.+...............sh..Fsp.R.lIlo....T...Ts.cWu....p...NA-cs.l....ps....Q.t...hslp+Isht-ltp.....S.IDWshh..t......t.............................................................	0	17	32	42
+12998	PF13157	DUF3992		Protein of unknown function (DUF3992)	Aldam G, Mistry J	gba	Pfam-B_480 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 98 and 122 amino acids in length. There is a single completely conserved residue T that may be functionally important.	22.00	22.00	22.00	22.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.14	0.72	-3.79	10	220	2010-08-02 13:24:37	2010-08-02 14:24:37	1	1	84	0	11	114	0	90.20	46	77.59	CHANGED	VCssWshs..suAsshllYssNlsQsIsGTGaVchDsGsu.....sITVshl...ssGTsVsThTVsPGoStSFThRcFsoIpIls...ssuGoppGcaClTh	.............VCosWSh...ssAhspllYTNNIsQpVhGTGaVKYDVGsu.....PITV-hL...suGTVlDThTVpPGoShoFThRcFsolpIss......Tssss.QGEFCITs.........	0	0	5	5
+12999	PF13158	DUF3993		Protein of unknown function (DUF3993)	Aldam G, Mistry J	gba	Pfam-B_782 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.	22.40	22.40	23.60	63.80	21.20	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.37	0.71	-4.31	5	94	2010-08-02 13:25:49	2010-08-02 14:25:49	1	1	94	0	5	39	0	119.70	79	72.48	CHANGED	hIhLlthlsVAFLVsaulTpl.uK-csKlDRcEVFpTlQouaEsQFSLoEKcRoMs-MhulL-PYFT-uFtslFl-ENups-cpG..haGoDhGEYhIPs....FSFou-TKluhD-E+..lYVYEass	..................GIWLVLFVCVAFLVGYSVTTVLGKEEVKlDRKEVFTTIQKGYETQFSIRGKHLPMNKMIETLSPYFT-NFLQVFTDENSRSDKQS........GEYLLPAKEAPFSFNSETKMSYDEEHK.LYVYERs...	0	0	2	3
+13000	PF13159	DUF3994		Domain of unknown function (DUF3994)	Aldam G, Mistry J	gba	Pfam-B_903 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 97 and 111 amino acids in length.	25.00	25.00	25.40	27.40	21.60	24.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.65	0.72	-3.79	21	98	2010-08-02 13:26:55	2010-08-02 14:26:55	1	1	44	0	2	81	0	109.20	40	32.91	CHANGED	psKphs-cupchlccGschWppsacslcsch.tt.p...............sthptsohossc.p..p......................sspsslspDGpELlGsWGh.pss.tFphulsh+p..DsTFpsYss.uphs	.......TDKEll-KupphlcEucphWt.sFccLcu-h.t..tt...............phssuosSspchpphptKsGl.ps..............NsppNl.KDGTELlGsWGhptus.GaphoLlLKu..DKTFEoYus.GpYP...	0	0	1	1
+13001	PF13160	DUF3995		Protein of unknown function (DUF3995)	Aldam G, Mistry J	gba	Pfam-B_958 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 138 and 149 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	22.70	22.70	24.00	23.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.83	0.71	-4.08	35	198	2010-08-02 13:28:22	2010-08-02 14:28:22	1	1	181	0	58	169	10	119.90	35	82.04	CHANGED	hLssluhlH....lYWAhGGpWshps.shsspss.......tsshtPuhsushhVAssLhsu..Asllhhpsh.h.ht.hh.ttlh..phushsluslhhlRu.....lushtaluhh+chts..shFuchDshlYsPLCLhLuluhh	............................hLhhluhlH....lYWAhGGpWussu.slPscss..............chshpP.sshh...TL.hlAlhLshA..Ahllltpss.h..hththsshll.phuuhls...hllFhlRs..............lG-FpYhGh.FK....+h+s..opFA....RhDThlY.PLChhLuluh.........................	0	16	35	46
+13002	PF13161	DUF3996		Protein of unknown function (DUF3996)	Aldam G, Mistry J	gba	Pfam-B_998 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 203 amino acids in length.	21.90	21.90	21.90	29.80	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.18	0.71	-4.58	16	146	2010-08-02 13:29:55	2010-08-02 14:29:55	1	1	31	0	17	100	1	156.00	34	82.20	CHANGED	ths+pptsppphGhGhulssPIsNhhlphshhsl-IGaGsaNGlpss.........sFhshlhhul......DhlFhpphhcphs..lssulGhGh....GphhhSshpsst................psssphulGhRlPLhlpaslh.Ksl-IhhKssPuIt.shahsss........h.Gh+aphFuuhhl+h	...h.tKcppsppthGhGhulG.PlANhhlshsasshDlGaGuasGlpss.........sFhshlhhul......DhIFpp.lhcshs..lshulGhGh....GslhhSs.ppp.................o.ttclulshRlPLslpYshh.+slpIhhKhsPolt.shhhsss........h.Gh+aNFhushhl+h..............	0	5	7	7
+13003	PF13162	DUF3997		Protein of unknown function (DUF3997)	Aldam G, Mistry J	gba	Pfam-B_1597 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.	25.00	25.00	27.20	25.40	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.45	0.71	-4.26	10	103	2010-08-02 13:32:12	2010-08-02 14:32:12	1	1	101	0	15	57	0	109.60	67	75.10	CHANGED	pls-tYcLlNsussshtlhs.psslhpopa.h.l...sApVs..-IuaD-paIIAKpp..ph+sDshNscsslhscpsE...YWIIDlK......pschaGPasccpFpcKpcphpIscplphlpsahp	...............................................lNDEYELIRTSGNAFELFPoQDAVYATQY...I...PAKIT..DIAWDDKYIIAKQT..EEKSDPNNPDAAIANKKSE..HYWIIDVK........HNKRFGPYNEKQFpEQKDAFKIKVPFQslDuYI.K...	0	4	12	13
+13004	PF13163	DUF3999		Protein of unknown function (DUF3999)	Aldam G, Mistry J	gba	Pfam-B_2128 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 440 and 470 amino acids in length. There is a single completely conserved residue D that may be functionally important.	29.00	29.00	29.30	29.00	28.40	28.60	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.35	0.70	-5.53	34	171	2010-08-02 13:36:19	2010-08-02 14:36:19	1	2	165	0	56	185	19	389.10	29	87.18	CHANGED	stDaupthsLphsuu.usaYpLsLPtsVYttutpsD.LsDlRVFNusGcslPaALhtspst..s.ss..phpslphFsL.....sssuss.spssspltlptsssGsl....hthsssstssptpt..t.aLlDhoth......cs.slptLhLch.ssstps..clsVcASDDLpcWpsl.ucutlhcLspssppltpccIt.....Lss..hpuRYLRLhW..s..susthpssplpttsssshss.........shpaptsltsppsss.....spahaplstshPlsclclsLsQs..Nslssspl.u.......................Rssspt.......sWpslusuhL.aRLttsu..tc.tsssltls..spsscthRlpssp...uGhGsssPsltsuhpstpLsFlApGssPapLAhGssssts........sslshssLlsshpstp........ls.Aphst.....ssssussshhs..sssps...h++hsLWusLllG..VssLuhhAapL	.................................saspphsLphsut.usaYplpLs.sV.htutpss.LtDlRVhsutGpslPaul.s.pst..ttts...p.htlphFsL......sstts.ttsss.hhlph.sssGsl.......tststsuttth......saLlDhSth........ct..slptLhlca......ssshps.tphsl-uSDDLpcWpsl.ucuplhcLshsspplppccls..........................Lsu....tpARYLRLhh.ts.tsuP.tLtsscltsts..sss..ss.............shpWptshtsptsss............schhaph.ss.s.hPl..sclclslsQs...Nsls.spl.tu..............................Rssspt.......sWp.slusshL..YRLtts.s....tphpsstltls....uphs+thRLhlcp.s..sGLus.t..sP.pl...s...l.uh...pstp..LsFl.....ApG.ssPasLuhGssssps........s.slslssLlsshs.pp........ls.Aplus......htsussshh..s..sssps....h++hhLWusLllu...VhlLuhhAhpL.......................	0	10	27	41
+13005	PF13164	DUF4002		Protein of unknown function (DUF4002)	Aldam G, Mistry J	gba	Pfam-B_3350 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 112 and 125 amino acids in length. There are two completely conserved C residues that may be functionally important.	21.00	21.00	24.50	23.90	18.20	17.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.51	0.72	-4.00	26	48	2010-08-02 13:38:04	2010-08-02 14:38:04	1	2	18	0	22	50	0	74.50	36	63.43	CHANGED	CC......p.tppltaphtpst.......Ctshsupts.....tsC.phsICsDGpsl.hGs.aCGpGsCNlFGCsCcGGCl...pGshhpsFhcpssth	............................CCh.ttpltaphttus.......Cthssupts....shsC.chsICsDGpsl.hGo.YCGpGuCNlFGCpCcGG..Cl...pGsh.psFhchst.........................	0	5	5	15
+13006	PF13165	DUF4001		Protein of unknown function (DUF4001)	Aldam G, Mistry J	gba	Pfam-B_3337 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are at least two pairs of cysteine residues in this short family of proteins.	21.70	21.70	23.10	23.00	20.80	17.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.58	0.72	-4.29	32	277	2010-08-02 14:58:05	2010-08-02 15:58:05	1	2	276	0	55	184	1	43.90	66	92.19	CHANGED	KHIKTlsppsLpcohppGG.CGECQTSCQSACKTSCTVuNQsCEp	................KHIKTlNp.psLp..po..lp+GG.CGECQTSCQSACKTSCTVuNQsCEp...	0	36	51	53
+13007	PF13166	AAA_13		AAA domain	Bateman A	agb	Jackhmmer:O25761	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease [1].	45.20	45.20	45.30	45.40	45.10	45.10	hmmbuild  -o /dev/null HMM SEED	712	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.59	0.70	-13.53	0.70	-6.07	43	601	2012-10-05 12:31:09	2010-08-02 18:32:18	1	5	517	0	126	556	33	537.10	15	85.43	CHANGED	shusa.s..tp........ssp..lss.......hp+lNlIYGtNGoGKTTlSplhtshp.....s........cap..............ps.ph............phps.............s....p.............s..plh..VaNp-Flcc..Nh....s.....p...sp..lpul.asLGccsh-tpppIpphcpplpphppp..hpphp....pplpp..tpp.........phpphpsphp..cpshcph.pp...hppthp.pshpu..hpt.cpph........tpphlp..c.hps....hsts......shhs.cclpp.p....hptl.hssshpp.lshl.s....hs.h.s.hpt.l..-p....ssllpppllup...s.slscLlppls.s-WVc.............pGhc.ahp.......p..s...ppCsFCpp..lspphtppLppaFc-.sa...ppphpplpphhpph...psp...hpt..hhpp.lpphh.s.h..............t.hthp......hpplpp....ph.pt........lppt....l....pt...p....ppLppKhpcPsp.slp.l.csh.sshl......s............................plpshlsphNphIpcpNc....hspNhppcppphp.pplhtah.h.........t.chp..pslp..thp....cphp...shppslsshppplsptppclpshppc....lpcLcpplsshp.slcpINchLpsa...GhsshpLp.h....ps.c....c.st.....YcIhR.....p..s....s.p.ss...psLSEGE+ThIsFLYFhptlc...sss..sh..t.cspllVIDDPlSSLDsshlahlsuLI+shh......tp.sp.............h+QlFlLTHNlhFa+clp..h......hhp........p..........p..pts..p..p........spaa.h.......................lc..+...sss....tSpl...p.............sh.p.p.....pshpopYphL.appl.......pct..............t.........pps.....ssh.slsNshR+lLEsY..Fph...sph.....p...........c.plh.phhps..........pcp.th...tpu.lhcal.NctSHst.s.s-l.hshst.shp.chhplhcpIFp	.........................................................................................................................................................................h..............................h..shhaG.NhtGKoshsphh..................................................................................................................................................th...ha.tphht....h...............t...t................h........h.t...............t.h..t..t...h.......................................................................t.h...................................................................t..........................................t.......t.................h..................................................h.........................t...........................................t......................t.a..ht........................................s.ht.h...........t.t......t.C.hCtp.........................h..ht....h...tt...h...hp...p......t.t...........hp..t.....h....t...................h....................................................t.h...........h.t...........h..t.....h......t...........t..h....t...c............t..t..t.........................t....................................................................................................th....t.h.t.thtt..h.t.pp.......t.t.....h..t....t.....t...h....t........h..............................t............................ht.......t........h....t..t..t....t.h....t.t....p......t.htt.hp..t.t.....h..tth.p.t...ph.............p........h.....t.....t.....hst.lpth......t..th..p..lt..h.......ptp......ptt................ht.l...t............t..s.............t.p.........pplScGEcshluhhaFhtphp..............ptp.sh...........ptthlllDDPlSSLDppphhh...lh.sh...ltphh.................sp...............hp....p....lhlhTHsh..Fh.p.lp..p..hp..........................t..tp...............phh.h..........................................................lp.p......ptp.......p.h..................htt........p.h.p...a.t.h..h...ht.l.hph..............t.........t.t.........h..h.N.hRplhE...h..hth....t.........t.........................h.....t.h.t..................................h..phh.p..S..H.....................................................................................................................................................................................................	0	35	78	107
+13008	PF13167	GTP-bdg_N		GTP-binding GTPase N-terminal	Coggill P	pcc	manual	Family	This is the N-terminal region of GTP-binding HflX-like proteins. The full-length members bind and interact with the 50S ribosome and are GTPases, hydrolysing GTP/GDP/ATP/ADP. This N-terminal region is necessary for stability of the whole protein.	21.90	21.90	21.90	22.30	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.10	0.72	-3.86	6	4196	2010-08-04 10:27:35	2010-08-04 11:27:35	1	5	3967	0	960	2981	1188	93.80	42	21.38	CHANGED	DcpFNF-STMEELpuLSpTCQL-VhuQITQNR-pVDcKYYVGKGKl-EIKuFlEh+DI..DVVVsNDELTTAQSKoLN-sLsVKIIDRTQLILEIFA	..............................tpt.......ttsh.pELtsLuco.A.G..s.cl.l.t.s.l.sppRppsc...sphalGpGKl.cEltp.h...........l.......c........t........p...............s..............s....................s.lVlhs.c.c.LoPu.QpRN....LE......ch.h..............p.........s+V..IDRTtLILDIFA.............	0	319	633	820
+13009	PF13168	Poxvirus_B22R_C		Poxvirus B22R protein C-terminal	Mifsud W	pcc	Pfam-B_3510 (release 7.3)	Family	This is the highly conserved C-terminal region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.	25.00	25.00	211.20	210.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.08	0.71	-5.04	19	94	2010-08-04 13:07:16	2010-08-04 14:07:16	1	2	34	0	0	88	0	196.20	58	10.66	CHANGED	cspslhpsVSs.uLoplGuslusuG........hsuuPplAhAGhulpuIuGLIDhupsIYallSGpp...P.DPllcpFssYupalu.oscuGsRhChMPsS-lhlhlAYRp.....cs...p.uhEKhthaahDslsShlhYLpTStIshshplpVsCP.IGtLR.h-sDIsuYshLhhssc-sV+aYhhstlhshLSpaPsVphTCGp-.sLh	..K-EKIFEAVTh.oLSTIGSTLooAG........hhusP.LMIAGlGIohIoGlIDsuKDIYYLhSGpE..+PVDPVIKhFNTYAuLVSDosKhGVRKCLhPGpDTlIYlAY+N.....Do.SFKpssEthuLYFlDVIsScIhYLNTSNllL-YpLKVACP.IGsLRSlDlDITAYTlL.Y-TsDslK+Y+FlRhusLLSKHPVlRLTCGhssTL...	0	0	0	0
+13010	PF13169	Poxvirus_B22R_N		Poxvirus B22R protein N-terminal	Mifsud W	pcc	Pfam-B_3510 (release 7.3)	Family	This is the highly conserved N-terminal region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.	24.70	24.70	25.10	57.90	23.60	24.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.13	0.72	-3.80	18	90	2010-08-04 13:12:09	2010-08-04 14:12:09	1	3	32	0	0	83	0	90.90	44	5.09	CHANGED	pcpChRKhulYHshspshpt.+-phDhpup..ush+YLslscptEppphhpsFNWopIppsl+cpFlppCsssss.......YhYNYolshslolsspssh	...ETChRKoALYHD.phscs..c-NpDssAS..lsYKYLpVVpcRERoRLluoFNWTsIuEuV+N-FI+hC-lsus.......YLYNYTIslShhIcupc..ch..	0	0	0	0
+13011	PF13170	DUF4003		Protein of unknown function (DUF4003)	Bateman A	agb	Jackhmmer:Q188C9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 345 amino acids in length.	27.00	27.00	30.40	29.50	22.80	19.10	hmmbuild  --amino -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.73	0.70	-5.16	20	197	2010-08-04 15:11:32	2010-08-04 16:11:32	1	1	189	0	22	159	1	290.40	39	89.43	CHANGED	csYcplcps.thphssshlphhhAhhashpscphs..hschcclpphIKppouhFSshRuphphsluuhLslcts..psccthpphlplYspLppttFpcsp.ahhLuAhhlhpp..pppshcpplp+spplYcthKccH.FLTus-DhshssL.LAt..sspsl-plh-phEphYphLpc.hsht+uNsLQhLSplLsLtpspsppp.st+shplhptLcccclKlpp.a.hshlGlLullpssc.c.lcslpplh-pLpccctht...hp+chphhlAlsLhhschhsppp........hhcpsLttslphlltspps	.............sYtpLKsp.caphpDsRhthhIAthaAuss+lhs..ht+FhEIspaIKpQlGhFShL.......+.uhpRaslAuhLslc.s..sh+cuhcphlclYcpLlpuGFpRoh.aTYLAAhlLLpp......pp-phsppIp+uhplYctMKK-HhFLTuopDhshAVL.LAs..psEsl-pLh-csEhhYpcLAp.tGF+KGNsLQFLSpILoLtps.c-phhlupsssIhp.LKpc.clKlKphH.YPuIGlLALlpDu-.K.lculpslI-cLptc+hFR....app-tslhlAIpLassppu-c.p........tpspGLts.lclLItAQQA......................	0	9	17	19
+13012	PF13171	DUF4004		Protein of unknown function (DUF4004)	Bateman A	agb	Jackhmmer:Q183T3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 210 amino acids in length.	27.00	27.00	27.00	49.70	21.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.30	0.71	-4.15	9	172	2010-08-04 15:48:56	2010-08-04 16:48:56	1	1	169	0	26	122	0	196.20	57	94.62	CHANGED	EpLISKKELL-hssISYGQLYRWKRKNLIPEEWFIRKSTFTGQETFFPR-KILpRIspIpphK--lSLDELAchFSsp.hp-lplsppcllpcsllScsslchatp.hs.ptpsas.pcllslal...LEcLLpSG.lSl-EuptlstsLcpp.tp.ppKpspLhlhRKLGlshahllussscIhh-sssKVlp+lslsch....hEc	..p.-LISKKDLLELTGISYGQLYRWKRKNLIPE-WFlRKSTFTGQETFFPKEKILERI-KIQoMKEDLSLDELAsMFSPs.lp-lhLT+--lL+KGIsScsVLphFhEpps....css...pFpFs-lLhlYh...LEcL..LQSG-ISLEE.GKhlhpVLc-N.Ypuh.ccKss-Lll..lRKLGloTChLl.uss--llFEcGsKlVlR.slh+h.oE.t............................................................	0	8	16	20
+13013	PF13172	PepSY_TM_1		PepSY-associated TM helix	Coggill P	pcc	Jackhammer:O25020	Family	This family represents a conserved TM helix found in bacteria and archaea.	22.90	3.00	22.90	4.30	22.80	-999999.99	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.31	0.72	-4.10	183	2589	2012-10-01 23:59:14	2010-08-05 10:40:52	1	41	1548	0	728	5088	380	32.10	26	8.70	CHANGED	htphhtphHhahuhhshshlllhulTGhhlsapp	.............hhhphH.hahulhssshlllhulTGlhhha..............	0	180	437	605
+13014	PF13173	AAA_14		AAA domain	Bateman A	agb	Jackhmmer:O25880	Family	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.88	0.71	-4.24	476	3483	2012-10-05 12:31:09	2010-08-05 13:21:57	1	24	1307	0	833	5752	2489	125.60	23	29.71	CHANGED	sptslllpGsRpsGKool...l.hph.hpphh........pphlal.s.h-c.....ph................ht....ht.....t...h.................phhhp.h....h...............tt.h..lhlDElQps......................s.s.h.phl+tlh-.......pt...t..h....clhlTGSsshhl...p.phs.........splsGRhh............hclhPlSFpEah	...........................................t...hlllpGsRpsGKosl...l....tph...hpphh..................................tph..h..h..l..s...h-s......ph......................................................tp...ht.....t..................h....phhhp.t.......t......................................ttth....lhl...DE....l....Q..ph..................................s..p..h...p.h..l.+thh-..........pt.......p.....h..........ch.h.loG..S...s..s..h...h..h......p.....ph.s.............p...h..s..G.R.hh..........................h.p.lhPhoatEh..............................................................................................................	0	327	580	714
+13015	PF13174	TPR_6		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:O25749	Repeat	\N	25.70	10.00	25.70	10.00	25.60	9.90	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.27	0.73	-7.87	0.73	-3.13	402	6355	2012-10-11 20:01:03	2010-08-05 13:32:42	1	1348	2675	10	2337	34545	12501	32.30	19	8.58	CHANGED	pAh.hphu.hshh.p.t........t.pts..pAtp..hhppllpp.aPso	........................................................sh.hphu.hhhh.p.t......................................s.php.....pAhp....happllpp.aPp...................................	0	982	1643	2054
+13016	PF13175	AAA_15		AAA ATPase domain	Bateman A	agb	Jackhmmer:O24997	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.52	0.70	-5.43	19	1024	2012-10-05 12:31:09	2010-08-05 14:14:22	1	20	787	0	211	6175	1983	226.90	14	45.90	CHANGED	l+plpIpNa+shpsh.............................clshsc..........sls........lllGpNssGKoslLcul.........t.h.s.p.....tp...............................................t.tph....pp....hp...................h.tt.ptlplpthlppssschhus.....h...p..h....ppspsp..hhhh.p.lc.thchhh.sphpchchhpphst..................................................ph..h....t...p.......phph.ph.hhtth.p.....h..pt.h.tt.phhpchhssts..phpphhp.shhcthct................ttcthhpshspplpphhpcths................tshthp.spphts...........................st.hp.phplsps.lphhhp.........psp...p......lslpppupGhp.hhhhslhhsphptps.sp..........IllIDEPEsaLHsshQpphlchLpphsp..........sh..QlI.................lTTHSPall	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....p...t......t...u.......G....hp...............h.h...h.............h......h........h..................h..t......t..t.....h..t...t.......................................lhhl-EPEsphHsphQh.....h.h.p.h.l....p.h.ht..................................th.....Qhl.................lo.THSshl.............................................................................................................................................................................................................................................................................................................................................................................................	0	67	124	176
+13017	PF13176	TPR_7		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:O25374	Repeat	\N	25.00	14.00	25.00	14.00	24.90	13.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.64	0.74	-8.06	0.74	-3.73	162	2738	2012-10-11 20:01:03	2010-08-05 14:29:41	1	891	1597	5	1042	30248	7638	35.70	24	5.94	CHANGED	sl.ttLuph.app...tGchccAlphacp.......l.tht........ps.tstp	...............h.hsLGpl.app.......pG.ch-cAlchapp...................h.t.t..................ph...............................................	0	404	612	833
+13018	PF13177	DNA_pol3_delta2		DNA polymerase III, delta subunit	Bateman A	agb	Jackhmmer:O25829	Domain	DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction [1]. The delta subunit is also known as HolA.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.08	0.71	-4.58	82	9575	2012-10-05 12:31:09	2010-08-05 15:02:19	1	36	4883	47	2332	8351	6088	159.20	34	34.48	CHANGED	tpsphhphLpptlpps...+luHA..YL.FpG.pGsGphphAhhhupt.lhCpptt.t...............sCtpCpsCp.pltp.........................tsaPDlhhl...........ps.cst.....................................................................................................................................sI+l..-pIR.pLppphshpshc.up.hKlaIIcsA-phstsAuNuLLKhlEEPs.spslhlLlopshspl....LPTIhSRCpllphpshs	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pt.hhptLtp.u.l..p.p.s......+l.sH.AaLFs.Gs.cGsGKsshAphhA+.sl.Cpps.ss.......................................psC.spCp..s.Cp.....tlpp..............................Gp.asD...l...h.tl...........................cs..sup................................................................................................................................................................................................................................................................................................................................................h..s...l........-......c...l.........R.......c.......l..h....-..p....s.....p..h..s.....P....s......p.....u....p.....aKValI--sc...h...L.....o...p.sAh......NALLK.T.LEE.P.P.sp.s.....h.FlLs..T..s..c..s.p..+l...........sTIhSRCppaphp...s............................	0	792	1517	1986
+13019	PF13178	DUF4005		Protein of unknown function (DUF4005)	Coggill P	pcc	Pfam-B_2171 (release 24.0)	Family	This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.33	0.72	-11.05	0.72	-3.79	69	399	2010-08-05 15:10:13	2010-08-05 16:10:13	1	6	28	0	239	398	0	120.00	20	26.44	CHANGED	soPp...............s...t.ttt.t.sss.p..tt.........................hPsYMAsTpSu+AK..lRSQSuP+.QRsps............tppssp............+RtShss.ss.s...............tttts.+Sss	..................................................................................ts....................t..t.......p.....p.ttppp.h..s...........................................sshPsYMAsTpSA+AK..s.R.....u..p..S.u...P+..pRsp.s..........................pppssp........................+RhShs..sssstt...........................tthtt.............................................................	0	31	151	199
+13020	PF13179	DUF4006		Family of unknown function (DUF4006)	Coggill P	pcc	Jackhammer:O24959	Family	This is a family of short, approx 65 residue-long, bacterial proteins of unknown function.	20.90	20.90	21.00	21.50	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.12	0.72	-4.42	21	189	2010-08-05 15:41:21	2010-08-05 16:41:21	1	1	189	0	21	73	0	65.00	57	90.90	CHANGED	M.ps.pRslFuLNGloGhLlAsVLLLuILssLThhuItsQpssAspsYp....lpcssulKMh..uspNsc+hh	...MENsNRsVFuLsGVTGMLIATVLLLuILVsLTlWGlKsQQEVhQpPYo....LKDl....puVKMh..uSccQDHh.s...	1	4	17	21
+13021	PF13180	PDZ_2		PDZ domain	Bateman A	agb	Jackhmmer:O24877	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.68	0.72	-4.09	52	19233	2012-10-02 11:12:46	2010-08-05 17:07:01	1	162	4727	36	5564	18896	7404	86.90	22	21.84	CHANGED	uslGlphptpps..................sshl.p........VtpssPutcss.lph..............GDhIhplssptl...psh.......spLh......phlh.ptp.GssVplplhR......sscppslplpl	............................................................................................Gh..h...t.............................................................tGs.h.Vsp.............Vh.s..s....u...P...At.......cA..G...lcs......................................GD..lI..l...p..l....s...Gps..l............psh...................p.clh................p.hl...t.....p......t....p....s..G..p...p...l.p.l..p...l..h..R.......s..G...p.p.hphpl........................................................	0	1926	3646	4675
+13022	PF13181	TPR_8		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:O25864	Repeat	\N	25.00	10.00	25.00	10.00	24.90	9.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.62	0.74	-7.70	0.74	-3.77	158	8299	2012-10-11 20:01:03	2010-08-05 17:20:12	1	2662	2423	16	3530	83745	27261	32.40	18	6.01	CHANGED	h.....ps.....hh.thGpl.ahp.hsph..cp...Ahphhpculplss..s.	........................................t...hh.tlup.h..Yhp..hs.ch........cp..............Ahphhpcshph.....t...................	0	1467	2293	2991
+13023	PF13182	DUF4007		Protein of unknown function (DUF4007)	Bateman A	agb	Jackhmmer:O26600	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 284 and 326 amino acids in length. This domain is found associated with Pfam:PF01507 in some proteins, suggesting a functional link.	27.00	27.00	27.90	27.70	25.30	24.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.58	0.70	-5.58	34	141	2010-08-06 09:59:40	2010-08-06 10:59:40	1	6	122	0	41	146	81	259.60	24	81.04	CHANGED	pFuuHE...........TFslRhGWLpKuhctlp.ps....sssFh..ccsuhsphGVGpNMVculRYWhpAsplhc-s.tt.........phTphGchlh.......shDPYlE-.uoLWLlHatLsss....pstAssWYhhFN.hshsc..Fo+s-lhphlpchhsp......tpphsppolpcDlssllpsYs...............ptsphssE-.hssPhsELuLlphs..ttpt.taphshss+ssLsstllhYAllcah...s..pstpolulscLhtps....sSPG+lFpLscpslschLcplpph..stlplscTAGLcplhhpp.......phtshchLcpaY	.............................FutHETF.hRtt....WLpKuhpth..tt..........phF....tppuhs.phGVG+NMVpu.l+aWhtAssllcpstt..........phTth.Gphlh..........................shD.ahEp.solWLlHah...Lsst............tptsssWahhFN.hp..t...p..p....Fscpplhphlpphhtp.........tpt...hupsolpc.DlsshlpsYs.................ttts.E-.hpssls-Ls..Llpth..........tpt.haphtpstp.slsstlhha..ullchh...t........tstpolshpplh.t......suPGclFpLscpslhchLpplpph.....shlp.hscouGlcpl.h.t...........thlt..................................	0	18	36	39
+13024	PF13183	Fer4_8		4Fe-4S dicluster domain	Bateman A	agb	Jackhmmer:O27906	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.92	0.72	-3.94	344	10837	2012-10-03 08:56:43	2010-08-06 11:04:20	1	158	3616	30	2967	16116	5623	77.90	24	15.69	CHANGED	p.hp...pChpC.u..tCt........ss.....C...........................P...................................................hhht.................................ht....h....tttth..t...................................................................t..h.........................................................htC...stCtt.....Cs..phCP.t.....sl	....................................................................t.htpClpC.G...hCh.............ss........C....................P................................................shtt...........................................................................................................................h.s......p.h...ht..ss.pstsht......................................................................t....htt.............................................................pthhsC...ssCts............Cs.psCPhpl................................................................	0	989	2028	2572
+13025	PF13184	KH_5		NusA-like KH domain	Bateman A	agb	Jackhmmer:O27285	Domain	\N	27.00	27.00	27.00	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.93	0.72	-4.17	54	4542	2012-10-02 00:34:43	2010-08-06 11:35:28	1	31	4481	7	1040	3009	2319	69.80	50	16.41	CHANGED	sGpRsKlAVtops.....plDslGuslGhpGsRlpslspELp..............sEKIDllpascD.......ppaltsALsPAcVhsVpl	.....................sGsRuKIAVpo..p-.....ppl...DPVGACVGh+GuRVpuVssELt..............G.E+IDIl......W.....s-.-......PApFlhNA.Lu...PAcVssl..l..............	0	356	687	885
+13026	PF13185	GAF_2		GAF domain	Bateman A	agb	Jackhmmer:O27394	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-11.13	0.71	-3.71	408	8344	2012-10-02 14:34:25	2010-08-06 13:27:49	1	1430	3034	23	3170	13907	1709	140.50	14	25.15	CHANGED	sts...h.pclhpt...h....l.p..tl.hp.......hh..sphuh.lh.......lh..cppp...................thh.hs......htsht..........tht..ht.t.....................................hpptcshhhs......................tt......t.h.htt..htshl..........sl..Plh.tps...p.lhGll.s....lts....tt...................tasp.p..chphlptlupthuhulp	............................................................................................................................................t......hht......h...h...p.....h..hp......hhs..hphuh..lh.............................hh........-tpt...................thhhhs........................h.t.uh................t...........h...t...........................................................................................hpppcshhls........................................................tt.h...........t.phspptsh..p..uhl................sl....Pl.........h..t........p.....s.......p.llGlL.s...........l.su.........tph...........................ttas.p..p....-..hphLptlut.hu.sh.................................................	0	1082	2191	2819
+13027	PF13186	SPASM	DUF4008;	Iron-sulfur cluster-binding domain	Bateman A	agb	Jackhmmer:O26216	Domain	This domain occurs as an additional C-terminal iron-sulfur cluster binding domain in many radical SAM domain, Pfam:PF04055 proteins. The domain occurs in a number of proteins that modify a protein to become an active enzyme, or a peptide to become a ribosomal natural product. The domain is named SPASM because it occurs in the maturases of Subilitosin, PQQ, Anaerobic Sulfatases, and Mycofactocin.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.70	0.72	-3.63	441	4320	2010-08-06 12:57:53	2010-08-06 13:57:53	1	60	2271	0	1134	3391	1345	67.60	24	17.48	CHANGED	C.........h....hpphs....lp.........ssGsVhs....C....................s..hhtph........tlGN.l......p......p....s.lt-.......l....a.pu......pphp...ph.....+pthhpt...............................hC........p..p.............Cs	.....................................stpt.hs..lp.......ss.Gcl.hs....C..................pth.....shsph........plGN.l....pp.........p....s.lpc..........................l............h...pS......tt.hp.ph.................ppt..phtp..............................t.C...p..p..C..........................................................................	0	484	821	978
+13028	PF13187	Fer4_9		4Fe-4S dicluster domain	Bateman A	agb	Jackhmmer:O27418	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.23	0.72	-3.70	188	5796	2012-10-03 08:56:43	2010-08-06 14:12:30	1	300	2244	20	1131	20878	5640	56.40	33	18.14	CHANGED	pChs.C......t....t.....C..hps.C.........Ptthh.hhtthtthhhh......................................................C.ht..Cst.........................Ch.psCPp.ssl	.............................................................ClG...C.....t.....h.....C..hsu..C............................P.h.s..lh.....ph...s...s...t.s...s.t...h.t...............................................................................................................................cC.sh.......Csp..........................................Cs....psCPs.sA.......................................	0	435	821	1007
+13029	PF13188	PAS_8		PAS domain	Bateman A	agb	Jackhmmer:O26558	Domain	\N	21.00	11.00	21.00	11.00	20.90	10.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.55	0.73	-9.73	0.73	-3.93	488	8124	2012-10-04 01:10:46	2010-08-06 15:34:09	1	1381	2453	5	2746	38264	3152	67.80	15	10.70	CHANGED	pphps....l...hc.....shst.ulh...h............h..c......t......................lhh......sNpshtchh........G.......ht...............hhsp.h....t...........thhsthptttt..thtp....hh.........ptht	........................................hps....l.........hc.......shsp.ull.....l...............................l..D......tts...................p.................................lhh.............sNp.sst.c...hh...............G.......hs................hhsp.h..t.........thh.........................tthtthttt......................................................................	2	951	1890	2360
+13030	PF13189	Cytidylate_kin2		Cytidylate kinase-like family	Bateman A	agb	Jackhmmer:O26138	Domain	This family includes enzymes related to cytidylate kinase.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.85	0.71	-4.37	174	1110	2012-10-05 12:31:09	2010-08-06 16:01:58	1	17	600	2	300	3886	1461	168.30	26	77.44	CHANGED	lITIuRpaGSGG+pluctLAccL.Glsh....YD+.-llphsAcc.tGlscphh.pph-Epss.........psh.h.thhht...................................shshs-plaphpp...c......lIpcl.A.p.ct.ssVIlGRCAcalL+-..ps.ss...lplFlt.Ash-tRl...............cR.lhcp....h.sls.c.c.cApchlccpD+pRppa.apaYT..spcW.....GcspsYDLslsoup	......................................lITIuRphGSGGppluctLAccL.Glth...........Y..D......c....c...l....l....p.........h.....A.....c....c.....p.....G.l......s......t......p....h.....h.....pph.sEpts..............tsh....h....hh..........................................................ph.hscpl.a..ph..pp....c......hI....p........c...l...A.....p...c.....t...s...s....V..l......l.G.R.s.A.s......a.l..Lcc........hs...ps........l..p....l..a.l..h..A.s...h-hRl........................cR.....lhcp.............t...s..hs...t....c...cA.....pc..hl....p..c..p..DcpRtpa...Yphas..sp.c.W.....sc.s.psYDLslsou.................................................................................................................................................	0	141	243	275
+13031	PF13190	PDGLE		PDGLE domain	Bateman A	agb	Jackhmmer:O27741	Domain	This short presumed domain is usually found on its own. However, it is also found associated with Pfam:PF01891 suggesting it may have a role in cobalt uptake. The domain is named after a short motif found within many members of the family.	27.00	27.00	27.30	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.17	0.72	-4.30	127	379	2010-08-06 15:35:55	2010-08-06 16:35:55	1	2	367	0	183	378	172	89.10	25	37.34	CHANGED	llsulllushluhhAS............usPDGLE.shtth..........pstp-hsh.pps.....t.........u.hsDYul.s....uhsp.........................................................hGssluGllGshlslsluhuluhl	......................h.lhulllusslu.hhAS............ssPDGL..E.shpph.....................tstp.ch...sh.ttt.....t.ht...................u.hsDYul..s......Ghss...................................................lGshluGllGshlslslshslsh.h....	0	65	130	163
+13032	PF13191	AAA_16		AAA ATPase domain	Bateman A	agb	Jackhmmer:O27636	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.44	0.71	-4.30	217	4712	2012-10-05 12:31:09	2010-08-06 16:51:29	1	525	1445	1	2447	16457	2610	171.70	16	17.45	CHANGED	plhGR-ppl.....ppLtshl..t..thtpups..............thllltG.sGsGKosl......lp........p..lhpthtpp...................thh.hhpspttph.......................shtsh.tphhpplhpp...hhst...........................................................................hh....................................sshsshsssptp......................h....phlp..........ph.l.............................tthspt........pp.......................................lllhlD-lp..............hh-.....pss.........hph.lpt..L.....hpt.........hpt.....................slhll	........................................................hhGRptpl...ttl.t.phl..........t....tht.ts.ps..............................p.s...l.l...l.t...G....sGsGKosL...............lp..............................p...l...hpp..htpp.........................thh...h..hp..s.p.sspt.....................................................sh.ts..h.....tph.l........p..p...l...h..pt...............hht................................................................................................................................................................................................................................................................................................tt.hs..s.t.tht.......................................................................h................thht.........................ph...l................................................................................t.t.httt....................tt.............................................................................................................................................................................................................................................lll...h....lD....-....hp....................hhc..........tts.................hph..lt.....l...hp.............................h........................................................................................................................................................................................................................................................................................................................................................................................	0	925	1663	2175
+13034	PF13192	Thioredoxin_3		Thioredoxin domain	Bateman A	agb	Jackhmmer:O26981	Domain	\N	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.70	0.72	-4.16	112	2658	2012-10-03 14:45:55	2010-08-09 14:50:14	1	25	2065	41	788	3102	540	77.70	30	21.59	CHANGED	hcI+l..l..GsG.C.spCp...pltphscpulpch.u.lsu....plp+....l.pDhpcI..hpaGVhsTPul.lls....sclhhsGp.lPstcc.lpplLp	............................h...cs.hh...Sho..C.psCP.......sVpsh.s...h.h.u...l...h...ss....s...lpt...........shl-........s....sh..h...p-l.....pp..h.....s.lMuVPul..hl....s........G...c.........h...s..p..G+....hsh.tc..ltp.................................	0	267	506	666
+13035	PF13193	AMP-binding_C	DUF4009;	AMP-binding enzyme C-terminal domain	Mistry J, Eberhardt R	jm14	Jackhmmer:O26318	Domain	This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.82	0.72	-3.03	574	45096	2012-10-03 01:00:17	2010-08-10 11:53:00	1	1760	5076	96	14992	41390	10507	76.60	27	9.63	CHANGED	ElEssL.ssH......P....s.V..sEu...AV..lG...hs.Dp...........hpG.ptl.hAaV..lh.........................................t...pc....lpph.......l.....pp......p.lu..........shthP.p...lhhl...s...LP+TpoGK	..................................................ElEssL..hp.a............P......s..V.....t-u.......s.V................lu............hs..ct...................................hhG..ctl...hAal..lhpt...........................................................tshpt......pp........lppa..........l........pp............p..Ls......................sat..hP.........hta...l.......s.........LPhTssGK...............................................................................	0	3967	8666	12279
+13036	PF13194	DUF4010		Domain of unknown function (DUF4010)	Mistry J	jm14	Jackhmmer:O27500	Domain	This is a family of putative membrane proteins found in archaea and bacteria.\	 It is sometimes found C terminal to Pfam:PF02308.	30.00	30.00	33.10	33.10	29.80	29.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.37	0.70	-5.03	138	426	2010-08-10 12:49:28	2010-08-10 13:49:28	1	3	381	0	187	409	49	207.30	28	50.08	CHANGED	VlluuloasGYluhRhhGs+tGlhloGlhGGlsSSTAsThshucpu+p.pss......hsth..hsuulllAsssMhlRlllls.sllss.s....lhh.tLh..hPhhs..hslsshssuhhh..h+p.......tttttt.ssshs....pNP...hpLpsALtFuhlhsllhlhsphhpphhG.ssGlhhluhluGlsDlDAhslSlsph.hsss.plshssAshulhlAshuNslsKssluhhhGs	.....VlluuluahuYlshRhhGscp..GlhloulhGGlsSSTAsshshucpu+p..pss..........sth.hsuuhllAss.sMhlRhl...lll.sllss..s........lhh....tlh...hshhs..hslssh.shuhhh....h+p...........ttttts...stphp.....pNP.hpLpsALhFuslhsllhll....sphspphhG.suGlhhluhluGlsDlcAhslolsph.tsss..plssssushulhlAhhuNslsKsshuhhhG.....................	0	54	131	166
+13037	PF13195	DUF4011		Protein of unknown function (DUF4011)	Mistry J	jm14	Jackhmmer:O26588	Family	This family of proteins is found in archaea and bacteria. Many members are annotated as being putative DNA helicase-related proteins.	22.20	22.20	22.70	22.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.10	0.71	-4.25	100	425	2010-08-10 13:28:15	2010-08-10 14:28:15	1	28	396	0	147	436	75	172.30	23	10.16	CHANGED	cLLDLohR.NpLLNhp...tspp.slplhsss.....ssplt-h..L.sp......upshphhs......hsp.t.....................................ts.p...stthhptpshp..........chttph....htpth......................pcpplh....................................................stlstppL...pp+..LhpLappA+ohh-EsGsNsLYLAlGhLcWhc.spps....cp.hhAPLlLlPVpLpRp...sspp.....sapl..phps--.hthNhoLhphL	......................................................................................................................pLLDhsh.R.Npllsh........stp..sl.lhs.t..........s.l.ph..l.tp......tpthphhs....h.t...................................................................................................t.........t.p.....................p...t.......tth...................................................................tpppl.................................................................................s.h.st.ppL.....ppp...LtpLhcpu+shhcEsGsssLaLAlGhLcWhc...spss......scshhAPLlLlPV.pLp+p..ssts.....tapl...phc.p--..sthN.oLhphL........	0	62	95	120
+13038	PF13196	DUF4012		Protein of unknown function (DUF4012)	Mistry J	jm14	Jackhmmer:O26332	Family	This is a family of uncharacterised proteins found in archaea and bacteria.	28.00	28.00	33.00	31.40	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.70	0.71	-4.04	44	176	2010-08-12 09:26:21	2010-08-12 10:26:21	1	3	119	0	73	178	61	143.00	31	24.84	CHANGED	cGsRsYLlhsQssAEhRusGGlsGuhullps-sGplslsc.h..tsssch....htpssss.hss-pts..has.....t.shhhpDsshsPDFspuAphhpphWppps...Gt.slDGVlulDPVsLshlLpss.GPVsl..s.DGp..........slsusNsschlhsssY	....sGsRsYllhsQssuEhRuoGGllGuhuhlss-sGplslsc.h..tsssch.......hspsshs....hssc..ptp...lau..............hthsh.hpssshsPDFspsAphhpshWptps...sp.slDGVlulDPVsLptlLtss.GsVsl..s..DGp............slsusNssphhhsssY........................	0	22	51	61
+13039	PF13197	DUF4013		Protein of unknown function (DUF4013)	Mistry J	jm14	Jackhmmer:O27260	Family	This is a family of uncharacterised proteins that is found in archaea and bacteria.	26.90	26.90	27.10	27.30	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.40	0.71	-4.92	99	205	2010-08-12 09:39:34	2010-08-12 10:39:34	1	1	98	0	137	208	21	168.40	18	63.89	CHANGED	lllssll....hlsllshhllhGYhlclh+ps....hst.pshPc...a.s..sasphhhcGlhh....hllsllahllshllhhlhhhhshh...........................s..hh.........slhshhhsh....lhhllsllhuhh.hsh....uhspautps.phssuFphsplhphlp...hhhhta......lhshll.hhllshlhshlsslhhhl	......................h.hlhhll....hlsllshhllhGYhhclh+ts....hs..sthPc...a.p...sasphhhcGlph....hllsllYhllshllhhlhshhhhh.................................s..hh................hl...hsh..hhhl......lsh.llsllhshh.hsh......uhsphutps.phtuuFphpplhphlp.t..hshhpa.......llshll.hhllshlhshlhhhh...h..............................	0	37	99	126
+13040	PF13198	DUF4014		Protein of unknown function (DUF4014)	Mistry J	jm14	Pfam-B_4873 (release 24.0)	Family	This is a bacterial and viral family of uncharacterised proteins.	23.00	23.00	23.70	23.50	22.20	20.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.41	0.72	-3.57	5	132	2010-08-12 10:49:27	2010-08-12 11:49:27	1	1	102	0	1	55	0	70.70	74	91.89	CHANGED	Ms+ha+K+YPRKSRsTEFLFLILFIVLM..lPISPLIllWlIG+..........................IlEhVIELYsDVVWuSFNsLHNKINPY.......KEN	.....MsphhcKpYPRKSRsTEFLFhILFIVLM..IPISPLlhVWhIGK............................IIEPVIELYsDVVWASFNTLHNKINPY.......KEN....................	0	0	0	1
+13041	PF13199	Glyco_hydro_66		Glycosyl hydrolase family 66	Bateman A	agb	Pfam-B_3959 (Release 24.0)	Domain	This family is a set of glycosyl hydrolase enzymes including cycloisomaltooligosaccharide glucanotransferase (EC:2.4.1.-) and dextranase (EC:3.2.1.11) activities.	23.70	23.70	23.80	23.70	23.60	23.60	hmmbuild  -o /dev/null --hand HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.87	0.70	-6.11	25	143	2012-10-03 05:44:19	2010-08-16 13:58:58	1	19	112	3	25	168	3	475.00	26	70.15	CHANGED	sTDKApYpPG-.sVphslshpss.......ussplchpHLs.psltpp.phshtht.spshs.....WpsPssDF...pGYhVclhs.ppssstlspsshAlDVSSDWs+FPRYGalus..Fsss...........s.pphpppl-pLsc.aHINulQFYDWta+HcpPlstss..tp..psWsDhu......s.RplttpsVKshIstsHphGhtAMhYNhlYGuhpshtp............sGlp.-....Wtlaccsspt......p.-pasL.....sp.h.ss..lhlhs.PsNssWQsYlhsptscshcphsFDGaHlDQlG.sRusl.a.......shsGpsl..........p..................LsssausFlpshKptl.sstp.........LVhNsVssautpplus.ushDalYsElW............tspssYssL+phlcp.....scph.sps.....upssVlAAYMsa...........................................................stus.ssGt.................................................................FsTsuVLLsDAsIFAuGGsHlEL......G-........phLspEYFPspsLphs.ccLpcphhsYYDFlTAYENLLR.....DGtsp....sssshsssstph.Shs....................sptspVWshuK.cssstc..llHLlNhhGss..shsW+c........ssuspspPpphpslplpl........ptss.plppVahASPDh.tsGsspcLsFpp....sGs.V..pholPpLpYWsMlhl	................................................................................ssKuhYtsup.pV.hphp.t..............hthphphhhht..phltp...ht.....ttph...........hp.Ptpph...pGYhspl.h..ttspth......tshulsVssshtpFPRYGalus..a.pp................tp.tttht.hpp.hplNsh.FYDhh.ctp............Phsts................................tpa.sh.......t.ppl.hpsl+phlpth+phGhhuhhY.shhh.us.ps.h.p.............tsst.p....hhlapsssp...............t..thsl.....st..h..s.....hh...hhs.Psstp.WQpYlhpp.ppshpphuFDGaphDplG...ppssh..h.......shs..up.h.............................lppsassFlpshKpth..sh..........lshNsVst.s.pplst.....up.DhhYsElW.............t.pstatsLpthltp....stth..............thshlhuAYMphtttt...............................................................................................................................ttt.hppsuhlLssAshhA.GG.Hhpl............Gp.........thLtptYaPsps.hphs.pphppt.hhpY.pFlsuYpNlLp.....Dsthp....t.s.phshsshth...uhs...................sptsplhshsK..ps......sshp......hlphlNh.shs....s.sW+s................us...pPth.pphtlph.........htt...spplahsSPD..t........tut..plthp......pst.l...hslPpLphWsMlh........................................................................................................................................	0	12	19	24
+13042	PF13200	DUF4015		Putative glycosyl hydrolase domain	Bateman A	agb	Pfam-B_597 (Release 24.0)	Domain	This domain is related to other known glycosyl hydrolases suggesting this domain is also involved in carbohydrate break down.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.04	0.70	-5.52	62	311	2012-10-03 05:44:19	2010-08-16 14:08:57	1	12	292	0	87	459	246	298.50	31	62.60	CHANGED	GlYlouhsuus.pt.h-cllchlcpTcLNuhVIDlK....-DpGplsapp.psstspthssspsh....hDhpthlccL+ccsIYsIARlVsFK.DshLAct.....+P-huh.ppssGslWpstpu.....u.........alNPapc-VW-YNlslAccAAchGFDEIQFDYlRFPs.....pt.tcpLpastsshpp.......................................................................+ssAIssFlthA+-cL.pshsV.lSsDlFGhssts....cssuIGQshppluppVDhISPMlYPSHassG................aGlc.pPDtcPYclltpuhpptpptlsth........tshhRPWlQsFTssaltt..hhpYGspplcsQIcAltDs..GhspalLWNAuNpY	...................................................................................................ulYlouhshss..p.h.hcphlchhcpotlNuhVIDlK....sDpG.lsa.s.pst....h..s...p.t..h.....s..s....spsh..............hD...h.tt.l...lcph+cpsIYsIARl....V...s.F.......K......D.sh.Lu..pt................pP..-.hul.....pptsG..p.h....Wp..s..tps..........s.....................W.lsPapc.csWcYN.l....s.lA.c.E....A.A.c.h..GFDEIQFD.YlRFPs..........tt.sppl.pa.s...tsptp...p...................................................................................+ssAIssFLphA+.cc.L..t...h..s..l..lSsDl.F.Ghsshs....sstu...IG........Qphpt..l..u..p.....VDhISPMlYPSHas.uh...............huhp..PstcP...Yphlhpuhtcstphh..tt..................tshhRPWlQsFpsshhtt...h.Ys.pplctQlcAhp-t..shstahLWNusNpY.....................................................................................	0	43	66	74
+13043	PF13201	Xylanase		Putative glycoside hydrolase xylanase	Coggill P	pcc	JCSG_target_393205	Family	This is a family of putative bacterial xylanases. Comparative structural data from TOPSAN indicates there to be a C-terminal carbohydrate binding domain similar to those of carbohydrate enzymes such as glucanase and xylanase. There is also structural similarity of the N-terminal domain, according to TOPSAN, to endo-1,4-beta-xylanase (from Streptomyces sviceus) and beta-xylosidase (from Magnetospirillum magnetotacticum MS-1). The N-terminal domain fold is an immunoglobulin-like beta-sandwich.	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.04	0.70	-5.62	30	518	2012-10-03 05:44:19	2010-08-16 14:49:09	1	35	171	3	105	458	18	216.30	18	43.09	CHANGED	oSCI+-EA.NAEADIp....u..s......psssshLhp...........ps.hssspIplhV..pp.ssDloplAPpFsLTsGATI........sPs...u......G......os.p......D......Fos...Ppp..............YTVTSEDGpWc+sYpVsh....hsspl....s.o..pacFEslpht.........p.t.cYplaY.-h.psuspp.....hp..WASGNsGFplouhu.p.ssp-YPTsQsss.G.hpGKClK.LsT+STGshGuh...l..tMP.IAAGNLFIGoF-ls.sAlsssLKAT+FGhPFp+..cPhpLsGYYKYKAGcpap....-.s.Gp..l....ss+KDpssIYAVhYEsscsst..........h.LDGs....Ns..hT..usp..lVulAcl..s..-s+E.........T..DpWTcFslPF.h.p.GKsIDts+LppGcYsLAIVFSSStcGupFcGAlGSTLaIDEVcLI	.........................................................................................................................................................................................................................................................t....t..t..p..l.h.l.............ts...s...l.pt.h....s.h.t..hs.......s..Aol............t.Pt..s......s......s.........................sasp.....t..............apVsuts.....t.th...p...Yp...lph.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	40	93	105
+13044	PF13202	EF-hand_5	EF_hand_3;	EF hand	Bateman A	agb	Jackhmmer:O26668	Domain	\N	25.30	11.50	25.30	11.50	25.20	11.40	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.82	0.73	-7.13	0.73	-4.38	149	5306	2012-10-02 16:17:27	2010-08-17 09:27:41	1	515	903	68	2797	37229	2719	23.80	30	8.51	CHANGED	lp.s..hFp.thDhstDGpIshpEh...pp..lh	...........h....hFp.thDt.s.tD..Gp.lohcEh.........h.............	0	1041	1668	2149
+13045	PF13203	DUF2201_N		Putative metallopeptidase domain	COGs, Finn RD, Sammut SJ, Bateman A	agb	COGs (COG4900)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. However, it is related to Pfam:PF01435.	23.20	23.20	23.30	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.95	0.70	-5.24	16	492	2012-10-03 04:41:15	2010-08-17 13:36:00	1	4	403	0	173	512	550	212.40	15	53.68	CHANGED	phppRhstAlt+hlEstPhhuuLsLhhphp-..ucsh......................tsstTDGc.plaYsPsF....-sLslsppVGllAHEVhHlALcHstRttsht......hD.plaNhAuDuhINssLlpsGa.tLPtsslh.pp.............csshtsasAEclYptl.........................tt.ttttuttptt..sputppstpppscu............t.hthssGtps-hsstsputussEttstput..cWpppltcthptG+usGph.utLtchls-hspsthP.WcplLRshls+slpc.s...chSWpRPsRRalu...........pssa.Pu.hp	......................................................ht.........................hhs..h..h.th.........s.th.........................s.h....ts....c...uh....hlhhsPthh......th...s........p...p...h..t...t...l...l....hH-lhHhhhtH.h..hRt.tt....................................hst.hhshAsDhs...lN...p.h....l.......p....t.h...........h..Ptshh..........................................................th.sEt....h.h.t.l...............................................................................................................................................................................................................................................................................................................................................................................................................t..............................................................................................................................................	0	70	126	158
+13046	PF13204	DUF4038	Hydrolase_6;	Protein of unknown function (DUF4038)	Coggill P	pcc	Jackhammer	Family	A family of putative cellulases. 	22.60	21.70	22.60	22.00	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.75	0.70	-5.08	28	345	2012-10-03 05:44:19	2010-08-17 13:38:46	1	8	222	4	120	308	23	264.50	24	58.13	CHANGED	spRaLhppsGpPFFaLuDTuWthhp+lsp..--hchYLcpR+ppGFNVIQhssLsph-uh....sh.sphsh..tpp.th.....thN..........sYa-HhDthlchAspcGlhlulVslWssts..st.h..........sslhsh-pAcsYu+alspRYcch.NlIWllGGDs............csspthchWpulupslpptsst.......LhTaHPpGp...pssschFcsp.WLDFpMaQSGHpp..psp...............s.hphl..phshpppPsKPllDuEPsYEshshshps........passhDVR+tuYhulhuGu.sGhTYGspuIWQah	...............................................................................t..+hht..tsGpPahhhu.-TsWthh.....p.phsp.............p-...h....phY.L.psppcpG.FNslphslls......p...h.s...h......................sh.s.....h...sh....t..................................hshtthN.........................................sYFc+h-hhlptstphGlh..s.s.l..l.h..a..s.s.h....t...tWh.....................shhs..-p...sptYscalspRatsh.Nl.l..Wh.luGDh.............................sptshphap.thsp..slp.........ph...sstp..............LhohHspsp.........ts.sph.......h...........psp..shlshshhQo.uHtt...tt..................s.hth.l.....t....p.ptt...hKPVlssEs.tYEs.h...........hshts..............hss.-lR+t.sa.ulhuGu...s..GhsYGtpslhph..........................................................................	0	57	94	107
+13047	PF13205	Big_5		Bacterial Ig-like domain	Bateman A	agb	Jackhmmer:O26670	Domain	\N	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.86	0.72	-3.44	269	1557	2012-10-03 16:25:20	2010-08-17 15:32:03	1	286	641	0	798	1779	1039	104.70	19	16.89	CHANGED	DsssP.sls..us.sPsss....us...sl..ss..ss..............slslsFsE.sl....pssshstshhh..............ssstsssls....s.s...................hsu.psl..slsPs..............ss.Lsss.TsYslsl.....ssu......lp.....Dhs...G..s..........h...............shs...a....sFoT	..............................................................................................P..tlh....sh.sPsss......us......sV.....ss..st...................sls...ls.Fsc..sl.........shssspts.l..hh.....................................ssssshslshp.........................................hsu..ppl..sls.Ps..............ss.Lpss.....o.....s...Yslsl.........ssu.....lp......Dhs..G.....s..................................shs...hsFoT....................................................	0	256	541	758
+13048	PF13206	VSG_B		Trypanosomal VSG domain	Bateman A, Jackson A	agb	Jackhmmer	Domain	This family represents the B-type variant surface glycoproteins from trypanosomal parasites. This family is related to Pfam:PF00913.	25.00	25.00	25.00	25.00	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.42	0.70	-5.32	132	958	2010-08-18 11:04:25	2010-08-18 12:04:25	1	4	12	0	708	958	0	291.60	15	75.39	CHANGED	hhlhlhhhs................ssusssssp......................Ntt-FpsLCp...llp.....luptt.....hp.st.sp...psssthpplt....tlNhohusss....ahp.h.ptttttp.ttt..tt.t..................ttWppsttthpp.ttp..........................................................t................thtphshpthsstttpthp................pltppAtplhpphp..ptttpttsss......thppt....lpp...AlYGsssssssst.............hssssspsss............C...........stsssssu.polssslhCLCssss...........................................................ssssphCspt............sssssshtssss...sspssap.pltstC...sttsssplT....ssplpsslt.h..........sthppttsssssphhLGp..........tssssCsG.s.....ssuhC.VpYsshhsst.....shsslsWlppLppAsppLpptppsptptpp.........htp.plptl	.....................................................................................hh.....................................................................................................................................................................................................................................................................................................................................h...h..h.tt.t...........t...tt.......hcpt...............htp.....sla.Gptssts..p...................................................tththsss....+sts......................C..............tsttsp...t....s..G...colssDhhCLCssss...................................................................................tpstpphCstt...................tsttt.s.h....t.s.s.t.t...................t.h.......pp.....s.....Wp..p.........lp.ptC....pttpp..t..h.p.................tplpphl.tph.........................tthhpt..tp.p.p.t.p.........t.....t.......h.h..LGt..................tptts.....CsGpp..................ssshC.V.Yttp...t.....................ttttlsWhpcl.ppuh.p..p.hpp.hpp..ttp..pt......................................................................................................	0	622	708	708
+13049	PF13207	AAA_17		AAA domain	Bateman A	agb	Jackhmmer:O26135	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.06	0.71	-3.29	412	3187	2012-10-05 12:31:09	2010-08-19 09:37:34	1	91	2065	29	1073	22418	10222	153.40	15	55.53	CHANGED	hlhls.G.ssGuGKoTluptL.....uc.p...............h..........s........h......h...l..phss.....................ht..shh.tht..pt....................t..p.....ph.......lpph.......................hhhcs.........................................................h.cht..tss......phlhhs...................hsh...........sttt......hhp..c.............................................cshsp	.........hlhlh.G.ssGoGKo....TlA....ppL....................up..p..............................................h..................................s..................................hs....................h.............l......chDs....l.h................................................ht...sht.....tht.....pt.........................................................................t..h.p.......................ph..............lpt................................................................hll-G..........................................................................................................ht.............................hhhh.............................h..................................................................................................ttthtt.h......................................................................................................................................................................................................................................................................................................................................................................................	0	356	664	893
+13050	PF13208	TerB-N	DUF4016;	TerB-N	Anantharaman V, Aldam G, Mistry J	gba	Anantharaman V	Family	The TerB-N domain is found N terminus to TerB, and TerB-C containing proteins [1]. It has a predominantly alpha-helical structure and contains an absolutely conserved glutamate [1]. The presence of a conserved acidic residue suggests that it might chelate metal like TerB [1]. These proteins occur in an two-gene operon containing an AAA+ ATPase and SF-II DNA helicase suggesting a role in stress  stress response or phage defense [1].	25.00	25.00	38.00	38.10	24.80	23.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.56	0.70	-4.89	152	214	2012-10-09 17:40:07	2010-08-19 12:01:53	1	12	206	0	57	217	8	206.60	24	30.87	CHANGED	Psc.hhphtshth..s.....................hh......u....................ht...sp.....-tsalptuh.h.As....sshsht.hshh.sYaPoYpslospp++uYhsWhupsRps.........ssssluYlFlahYtL.pplhl-ss......pcsht.tlhp.hpch............lshY...........hppah.pshl...hhhsl....s..........................hpph..........hhh.p...s...............................................pp.....hutc.shthhhsLuphhhc..pssl.........................schshhhst.sh.pltt....+ps	...............................tphhthtthhh.s.......hlu...............ht..sp...-tsFlp.uh.lAs.....sphsht.hshh.sYa.PoYsslospp++uYhpWhupsRps.........ps.sluYlFlahYtL.pplhl-ss......pcphstlhp.hp+h............lshY......hppahpshl...hhhsh.st..............hpch.........hhhp.s............................................pp..tutc.shthhhsLuphhhcppsl..........................schshshshsh.tlt.....................................	0	16	35	45
+13051	PF13209	DUF4017		Protein of unknown function (DUF4017)	Aldam G, Mistry J	gba	Pfam-B_2009 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	21.10	21.10	21.30	91.40	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.05	0.72	-4.18	15	75	2010-08-19 11:03:21	2010-08-19 12:03:21	1	1	75	0	4	26	0	56.90	82	94.07	CHANGED	MKNIlPALllYIIVClIAhIlPAS-GYNpVGWKLFVGQAYAIPIFlITAIITFYINKKKS	MKNIhPALllYhIVClIuhIhPASpGYNalGWKLFVGQAYAIPIFlITAIITFYINKKKS..	1	1	3	3
+13052	PF13210	DUF4018		Domain of unknown function (DUF4018)	Aldam G, Mistry J	gba	Pfam-B_2010 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 190 amino acids in length.	25.00	25.00	162.40	161.90	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.26	0.71	-4.92	6	74	2010-08-19 11:48:07	2010-08-19 12:48:07	1	1	73	0	3	66	0	186.50	77	56.30	CHANGED	hpKKsTGFllLhllQIIuCShFLsFSllGoILLPLFFFIVHAhssGhPVQKSLGuIlWFVVSAIFYA.PFPPLWKLlLLsLHIhlTFWLTGuNRNQQLlRFlSIITIGlhShLll.lFPYIRLlhSYlhphVALGFGYAlpPLhSAApLKDT--hWpNKGpLtcspIc-ss.p...FDPhllNSITIIlhTsIAl	...................................MpK+TTGFVILLlhQIlhhSlFLPFSLFGTIhLPLFFFIVHVVGPGYPVQKSLGGIVWFsVSAIFYA.PFPPLWKLLLLllHIMITFWLTGANRNQQLLRFsSIITIGlMSILIVQVFPFIRLIFSFIsEVVALGhGYAlNPLlsAAELKDTEDVWANKGHLLKPpIEDs+t...DFDPTLINSITIIsCTAIAI.......	0	0	2	2
+13053	PF13211	DUF4019		Protein of unknown function (DUF4019)	Aldam G, Mistry J	gba	Pfam-B_2012 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 130 and 183 amino acids in length. There is a single completely conserved residue E that may be functionally important.	22.10	22.10	22.10	22.40	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.24	0.72	-3.77	34	143	2010-08-19 11:48:56	2010-08-19 12:48:56	1	4	124	0	45	144	12	100.90	29	57.03	CHANGED	puAppalpLlDsGcas-sWcpAushh+stlspcpWsstlpssRts.LGsltsR..phhstpthsshsssPcGpYsslpapTpFsstts..shEplohhh-pDutW+lsGY	................sA.phhphlDus.....phsphWp.sAushh+stlsp.s.tasspltstRtp.LGslhsR..t.lsth.phs..sh.sshPsG..YsslpasTpFspssp...shEplohph-pDstW+lsGY.............	0	10	24	33
+13054	PF13212	DUF4020		Domain of unknown function (DUF4020)	Aldam G, Mistry J	gba	Pfam-B_2014 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 176 and 195 amino acids in length.	21.60	21.60	22.60	21.60	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.00	0.71	-4.70	10	80	2010-08-19 11:50:41	2010-08-19 12:50:41	1	2	80	0	5	73	0	175.10	70	16.29	CHANGED	VFIKCVLYWE..........................QKTDWLYPLLlpEsEEsKIKFMpaLCYYVKTLSs+EQQKFWsAWLusFLRERP..KMGsI....TsREYVMlLRhlLaMDEVhEKGLpll.ppF.sVpGcssptEhKQLahchLcKcEphKtahEhYAslFFhLLQsspEAshhEsEIIQIK-hLspapV-+clLshIcNEh	......................................VFIKCVLYWE..........................QKTDWLYPLLIpENEENKIK.FMQFLCYYVKTLSsKEQQKFWsAWLSlFLRERP..KMGtI....TAREYVMLLRIILaMDEIlE+GLsIls+uFSsVpGK.ssppEhKQLahEhLcK.pEShKhaKElYANVFFhLLQThQEAsLhEsEIIQIKELLltYcVEcpVlphI-NEI....................................	0	2	3	3
+13055	PF13213	DUF4021		Protein of unknown function (DUF4021)	Aldam G, Mistry J	gba	Pfam-B_2025 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved YGM sequence motif.	25.00	25.00	29.30	29.30	19.20	18.30	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.47	0.72	-4.33	5	82	2010-08-19 11:51:21	2010-08-19 12:51:21	1	1	81	0	4	36	0	45.50	80	77.05	CHANGED	K-NspcNsTsIpNNNTsNLslEEQAMNGLYGMPETsIEDADHAcT-	.............KENVTENsTsIQNsNTANLsIEEQAMNGLYGMPETsIEDADHAts...	0	0	2	2
+13056	PF13214	DUF4022		Protein of unknown function (DUF4022)	Aldam G, Mistry J	gba	Pfam-B_2027 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 85 amino acids in length.	25.00	25.00	79.30	79.20	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.78	0.72	-3.88	9	74	2010-08-19 11:52:15	2010-08-19 12:52:15	1	1	74	0	3	36	0	75.30	92	97.18	CHANGED	MLLSHIMtMDaIMSIlTLALLLLAElLVAIILIGVSIEICSYGWKKSNGIKYSCLLLSLLLGTASILGLhAAPAYFFIQLTEK	...............MSIlTLALLLLAEILVAIILIGVSIEICSYGWKKSNGIKYSCLLLSLLLGTASILGLhAAPAYFFIQLTEK.	0	0	1	1
+13057	PF13215	DUF4023		Protein of unknown function (DUF4023)	Aldam G, Mistry J	gba	Pfam-B_2030 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved KLP sequence motif.	25.00	25.00	34.40	34.10	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-7.66	0.72	-4.18	6	106	2010-08-19 11:53:06	2010-08-19 12:53:06	1	1	106	0	13	35	0	37.50	69	92.19	CHANGED	MpsTp-FV-Kl+EsQuKsc+N+c+QGpGsPu+KLPNKQ	...MSNSN-FLDTLHEKQAKDEQNRKRQGNGNPAKKKPNKT..	0	3	10	10
+13058	PF13216	DUF4024		Protein of unknown function (DUF4024)	Aldam G, Mistry J	gba	Pfam-B_2031 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved RDE sequence motif.	25.00	25.00	93.50	93.40	21.20	17.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.68	0.72	-4.15	6	71	2010-08-19 11:53:56	2010-08-19 12:53:56	1	1	71	0	2	7	0	35.00	97	94.59	CHANGED	MVGLSVTKlHLFRDENVNFLFCIEFMQKNELLLTH	MVGLSVTKlHLFRDENVNFLFCIGFMQKNELLLTH	0	0	1	1
+13059	PF13217	DUF4025		Protein of unknown function (DUF4025)	Aldam G, Mistry J	gba	Pfam-B_2033 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved EGT sequence motif.	25.00	25.00	33.60	33.40	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.76	0.72	-4.12	17	126	2010-08-19 11:54:36	2010-08-19 12:54:36	1	1	126	0	18	64	0	51.10	49	81.61	CHANGED	Kpppppt.p.lAscpasssshcsss.h.tuLAhTHEQVSDsYtEGTI-shlpcpsp	..........................KQpNKQslp.stpQs.YTScssssup......SVhcEQISDTlAEGTIDsKLs+tS........	0	5	10	12
+13060	PF13218	DUF4026		Protein of unknown function (DUF4026)	Aldam G, Mistry J	gba	Pfam-B_2037 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 450 amino acids in length. The family is found in association with Pfam:PF10077.	21.30	21.30	21.30	29.50	19.50	20.70	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.87	0.70	-5.56	11	104	2010-08-19 11:56:37	2010-08-19 12:56:37	1	3	104	0	8	85	0	295.70	54	65.82	CHANGED	EKcsSpMVAlPuoclTht.LEQRLEp.QThaT-G-IsYhs-t..suFFapC++s-c-L+FalpLsEsDs-.pI.pPYauTDslosELhAcAsAssQ-lhlEsLFps..cPLssYhQQLphlphLsPDLLLulD.SAAGKVhTREWlpFQLEs.DLhP-I-SLYVIHAVYDs-.......E-ssPThYWFHTHGLsRCGLoEsElIIPp.IuSYYGIPDLFpoFVNNuIpNGQIsFNEPIhIGQTpsGhEYLVAVPFEEGLcHVGpSTPlDsL+PLEEMpachpsss.pspFLGDhsDRDEhHQcPSVMLFRsspEpPhLESFFKGaEEQsAhMFhRT	............................................ERHFSDMIAVIPTRI...T..I.EQLKQRLEsIATKVD.-LKI..V....Y....SDE........TSLIVEL.....HMc...-plIPYELHIDEs.s.D..PE.EY...KhYNRQDoT.IVDRsFED.A.AaGTEIFTRT..LFVG....DVL-CFFQQLQFLWNLAP.DLLFVIDSSAAMKVISRsYIE.YHVEN.ELLPDIPDLYVIHSVYEDD.......K-uEPTQYWF.HTHGLLRAGVTEIELI.IP..N..R...ISSYYG..IuDLFQTFANNAVE.NGQVP.MNEPIVIAHSQQG.SIH.TVA.VPWEKGLSYIGHKTshDQLSSIE-EEVKLQPIsAQNTFLGGMDsRD.EYHQSPSVLLFKhsTSEEh.IESF.FKEHEEATGLMFYKT.....................................................................	0	2	5	5
+13061	PF13219	DUF4027		Protein of unknown function (DUF4027)	Aldam G, Mistry J	gba	Pfam-B_2038 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved CLGGF sequence motif.	25.00	25.00	30.40	69.60	24.90	16.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.28	0.72	-7.64	0.72	-4.52	13	86	2010-08-19 11:58:14	2010-08-19 12:58:14	1	1	75	0	2	42	0	36.00	77	90.50	CHANGED	MKuhQNLSYSQGVoLICLGGFsuSVsLAllIKhhpQ	MKuhQNLSYSQGVoLICLGGFAASVTLAVlIKlhHQ	0	0	1	1
+13062	PF13220	DUF4028		Protein of unknown function (DUF4028)	Aldam G, Mistry J	gba	Pfam-B_2040 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 67 and 93 amino acids in length. There are two conserved sequence motifs: IVKI and YVKKWF.	25.00	25.00	88.70	88.60	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.19	0.72	-4.33	12	74	2010-08-19 11:58:51	2010-08-19 12:58:51	1	1	74	0	2	39	0	64.00	92	87.78	CHANGED	MIVKILKDSSNSFLCTVQNKNG-pYVKKWFpKpcNpEELGRPTFKEVEKDWKENRESFMYPNlKA	MIVKILKDSSNSFLCTVQNKNGDQYVKKWFRKHENNEELGRPTFKEVE+DWKENRESFMYPNVKA	0	0	1	1
+13063	PF13221	DUF4029		Protein of unknown function (DUF4029)	Aldam G, Mistry J	gba	Pfam-B_2041 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 119 amino acids in length.	25.00	25.00	170.80	170.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.16	0.72	-3.61	10	73	2010-08-19 11:59:44	2010-08-19 12:59:44	1	1	73	0	2	37	0	94.80	90	89.30	CHANGED	MTKIELMALFLGYVFIFSNLNRIQEQSILEICIFSISIELFSIVSIVLLNELFphIHSFELhKFGNlVLQVICAYIVFVVLDKIlGQQTVFQDpRK	MTKIELMALFLGYVFIFSNLNRIQEQSILEICIFSISIELFSIVSIVLLNELFpWIHSFELMKFGNlVLQVICAYIVFVVL-KIVGQQTVFQDNRK	0	0	1	1
+13064	PF13222	DUF4030		Protein of unknown function (DUF4030)	Aldam G, Mistry J	gba	Pfam-B_2044 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 197 amino acids in length.	21.60	21.60	21.60	45.10	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.71	0.71	-4.48	6	71	2010-08-19 12:00:24	2010-08-19 13:00:24	1	1	65	0	1	48	0	136.00	73	72.54	CHANGED	sDpsRpVDLEIADT.s.oSclKp-INpQLKNQsI+PYTINlsQRsMcIVKpEpRWscVhuoIh--lFsKNGYKGFuIp.hNhEusQPhslsIpTpIssuDsGAKEFGcKIEKElsslLKTcclpKWI-sDSYTIEIYSpDpQK	..D-KpRhVDLEIADSEN.uNEIKKEINKRLQIQGIhSYKVNISQRN+EIVNAE+RWpLVFGQIFDDVFRKNGYEGFGIQQINYKKNQPVTIDIKTKIsDDEVGAREhGQKIEKEVEsVLKTEAVKKWIENDSYAIGIYDI-sR.....	0	0	1	1
+13065	PF13223	DUF4031		Protein of unknown function (DUF4031)	Aldam G, Mistry J	gba	Pfam-B_2059 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	25.00	25.00	25.10	25.10	22.90	24.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.73	0.72	-3.83	53	158	2010-08-19 12:01:13	2010-08-19 13:01:13	1	2	152	0	76	163	23	81.10	42	63.48	CHANGED	VYlDsstaP....h.+GphWuHLluDo.....h-ELHAFAs.plGlscRsFpp......-HYDlstpp+scAl.shGAlsls..sR-....ls+RLpsuG	......VYlDsstaP.....h.+GphWuHLluDs.....h-ELHAF.As.plGlsR.RuFpp........................-HYDlPspchs.cAl.thGAltls..p+c....Ll+plht..s...............	0	22	48	68
+13066	PF13224	DUF4032		Domain of unknown function (DUF4032)	Aldam G, Mistry J	gba	Pfam-B_2062 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 170 amino acids in length. The family is found in association with Pfam:PF06293.	22.30	22.30	22.30	22.40	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.95	0.71	-4.54	44	312	2010-08-19 12:02:02	2010-08-19 13:02:02	1	7	304	0	87	228	135	157.30	46	36.80	CHANGED	cpLWsELTspEsFsssEp.WRlppRIcRLN-LGFDVuElplpost..sGsplplpP+VVDAGHHpR+LhRLTGLDVpENQARRLLNDL-saRAs.......stpshs-phsAHcWLs-VFEPslculPt-L+uKLEPAplFHElLEHRWaLSEptG+DVshtEAlpSYlcsVL.	..............................pLWsELTst-pFsss-h.apl-pRlcRLNsLGFDVuELclpTss.........-GpclplpP+VVDAGHHpR+LLRLTGLDspEtQAR........RLLNDL-saRAp...................sshpsh-.plsAHcWlsElFEPsVptIP......E.....l..p....p...+....h....Es...AQhaHEVL-HRWYhSp+tt.+-VshsEAspuYlcslL........	0	35	64	80
+13067	PF13225	DUF4033		Domain of unknown function (DUF4033)	Aldam G, Mistry J	gba	Pfam-B_2072 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length.	21.40	21.40	23.30	31.30	20.50	18.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.13	0.72	-4.37	27	109	2010-08-19 12:02:47	2010-08-19 13:02:47	1	3	33	0	82	111	5	84.10	49	32.97	CHANGED	WLhGPsc.lpph-..................tptsuVhlcKCRYLEpSsCsGhClNhCKlPTQsFFccchGlPLpMpPNF-DhSCphhFGppPsshp-D	....................................WLhGPsc.V.ps-.......................ssGhpppoGVhlcKCRY.LEpSsCsGhClNhCKlPTQ.sFFpcchGlPLpMpPNFEDhSCphhFG.tPPshppD..........	0	29	63	75
+13068	PF13226	DUF4034		Domain of unknown function (DUF4034)	Aldam G, Mistry J	gba	Pfam-B_2075 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 280 amino acids in length. There is a conserved PRW sequence motif.	21.30	21.30	21.40	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.87	0.70	-5.31	8	236	2010-08-19 12:03:56	2010-08-19 13:03:56	1	9	217	0	29	143	1	257.00	50	39.77	CHANGED	+ppph.clcphLp-pca-ELDchh-pthst.apu+puEpc...Yshshss.s..hhDhsollus...t.ptLAhL+AWppApPcShHAalspupYWp+pAhchRohuWApcVTcstWlsAttss-hslhAtLpAlsLcPR.hhAuhhhhssoshFGpPsWLusllpGpcstspslhts..thctph.pEspAhhuppGLpshsph...st.hPssLPsts-.cchpcsh.YWLpssLuIaPptFhshp-Yl.ahhPRW.GGSac-IccFlsSslCcpLSptE+spLchhlhWD	.........................................................RcWpIsDIsuLLREcRY-ELDEpYsQAL..TcSFTS.R-AE+R......YFhAWspMc...FYDMcTLV-A....GP...pGLALI.KsWQ....+ARP+STHAWL...AEAQYWsHRAWLYR.SYGWA+-TT+AMW..lCAAACNEpMVlAsLpAIDp-PRQWMAAuLhp..TsSpsFGpPsWLsthLsGscssu.PLht-Lt-YaccoPQElsALMAaSGL.uascAlsPslshPulLPcpsD.D..uGpK...YWLtVsLsIFPTsFYlhsEYIPF+MPRW.tG.SH-EIp-hL-SssC-HLSstE+-+LclLIWWD.........................................................................................	0	3	14	21
+13069	PF13227	DUF4035		Protein of unknown function (DUF4035)	Aldam G, Mistry J	gba	Pfam-B_2076 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 67 and 93 amino acids in length.	22.10	22.10	23.20	22.80	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.69	0.72	-4.59	18	233	2010-08-19 12:04:48	2010-08-19 13:04:48	1	2	184	0	14	135	5	52.90	61	63.23	CHANGED	htFDRpsPlGDhRsDh+sAQIup..AshsuQGs+..sslsDhM.tWspc.....-cctpDDu	..hEFDRlSPLGDERGDIRNAQIV+..AVFGAQGhs..VuLcDAMLsWGED.....EDcsEsDP.............................	0	0	5	11
+13070	PF13228	DUF4037		Domain of unknown function (DUF4037)	Aldam G, Mistry J	gba	Pfam-B_2110 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length. There is a single completely conserved residue P that may be functionally important.	22.10	22.10	22.70	22.10	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.11	0.72	-3.78	37	317	2010-08-19 12:59:41	2010-08-19 13:59:41	1	17	297	0	68	282	5	100.10	31	26.79	CHANGED	WLplPpppLups.TsGpVFtDsh.GphophRppL..paYP-DlhhthlAsphhphuQtGQaNhsRshpRsDthuutlshscFlcsshpLlaLLN+....pYhPYa...KWh	.......................................pphlush.psGtlhaDt..Gchspl+ccl..tsYP--LtcphIucpLhhh...sp..........a....Nht....+sL+RpDhluhhtsls-hhcshhsllFhLN+....hatPhh...KW..............	0	36	54	60
+13071	PF13229	Beta_helix		Right handed beta helix region	Bateman A	agb	Jackhmmer:O26996	Family	This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.18	0.71	-12.28	0.71	-4.48	178	5365	2012-10-02 14:50:22	2010-08-19 14:58:07	1	525	1536	7	2617	9515	1881	170.30	13	29.99	CHANGED	sGl....hlpssss.................hp.....lpssplpss......................tssGlhltssss....................hhlp.s......splps.........t..ul.h.t........................spsslpsstl......psss.........................uhhh...sssshlpssplpss........ts..............Gl...h..s................sss....spl....psNplpsss.........................tsGlhltsss....................sh..psNplp............sst........................tsGl.hhssss...............splpsNph	................................................................................................................................................................t...................................lt..t..p.h..t......................................tt..tG.lh..ht..ssst..................................................hhlp..s.........................splts.............................t.tu.l..h.ht.ts.................................................................sss.tlpss.pl......................psst..............................................tGl..hh....t.....s......s....s.....s...s......h..l.p.s......N..plt...ss.....................sss......................................................................Gl..hlt.s..............................sss.....................stl............ps.N.p.lp.s..st.....................................................................tsG...l...h...ltsss..................................ph..h.ps.N.h.lh...................s.st...............................................................G.h.......................................h......................................................................................................................................................................................................................................	0	1057	1738	2217
+13072	PF13230	GATase_4	GATase_II;	Glutamine amidotransferases class-II	Mistry J	jm14	Jackhmmer:Q7LYB4	Family	This family captures members that are not found in Pfam:PF00310.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.65	0.70	-5.71	97	1953	2012-10-03 21:14:07	2010-08-19 15:05:10	1	8	1663	4	535	6397	3754	248.90	35	89.16	CHANGED	MCQLLGMNCAsPTDlTFSFoGFusRGGlT-cHuDGWGIAFFE..........DKACRLFlDpQuuusSPlAEhVKcYP.IKS+NsIAHIRKATQG+lhLENsHPFhREL.WGRHWIFAHNGDL.ps..asPpL....uGsYp..PVGsTDSEpAFChLhptLRctF.s.ts.pPsLsELFc.tlu-Lo+cIsc+GlFNFLhSNGQALFAHCS....T+......LaYlVR+a..PF.usAHLl.DtDlslDFuch..TTPEDRVAVIATpPLT.....csEsWTshpPGELlhFpsG...clstp.hplsss-tlhcchpss	.............................................................................MCpLhu.h.s...s..s...s...P.s...c..l..s..F..S...h...p..u...h.h.......p......R.u...G.....t......T.s...s....H..tDGa...G.I.u...FY-..............................s+.u.s.R..h..F..+....D..s...p...P....u...a......s.S.s..l....A.....c...h...l........p......p.....a.....s......I.......K......S.......p....s....V.......l..A..H.IRp...A..s.p..G.....p...V...s..l.p.N.o.HP.F........s.....R.....Eh...hG......c........p.W.s.a..AHNGpL...ss......a...c...slp................ssha.p........s......l.......G.....p.......T......D..S..Et.....A...F...C..h.l...L..p.....p..L....pp..........c..........h.....s.....t.........s....................ss...........h..s...........t........l.......hc.......hlt...........p.......l.....s............p..........p........l............p...........p.................t.................G.........s.........F.....N.h..l.L..S..D....G.c.h..lhA..as.s..............sp...............................Laals...R.c.s.........P...F...s...u......p.L.....h....D..p..D....h..p....l...c....h....t......p................sss..p..Dh..VsllATpPLT.................t.s.E.s..Wpth.sGphhhhp..Gp...................thh....................................................................................................................................................	0	134	273	423
+13073	PF13231	PMT_2		Dolichyl-phosphate-mannose-protein mannosyltransferase	Mistry J	jm14	Jackhmmer:O26471	Family	This family contains members that are not captured by Pfam:PF02366.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.14	0.71	-4.33	106	4872	2012-10-03 03:08:05	2010-08-19 17:21:47	1	112	2057	0	1921	6160	2870	159.90	15	29.25	CHANGED	c+P.....PhhsW..lh....tlhstlh..G.s.sthulhlssslhsslshhhlatls+ph.hs.ppsulluslhhss.sshhsssuh...ths..Dshhlhhhhhshahhhpshp..csp.h..phh...lhsulhhGluhhoKattshllhs.hll..aLlhs........th.hhpp..thsal.sshlslllh.s.......lhW	.........................................................shhhh..hh................th..h.h...t...l.....h.............G.............s..............h...............s........h.....+......l....h...s....h...l...h....s.h.h....s....s....h....h.l......ah....l............s.............c......c...........h.......h...........s.....p.............p..............s............u.........h.........h.............u.......u....l.l....h....sh....h.s..h.....h.....h.h.........hut.......hsp.....-...sh...h.........h..h...h..h...h.....h...u....h.....h....h.............h.....h...........p.....h......h..p....................pt.......p....h...........t.......h....h..............hh...h..u...l..h..h......u....l..u..h..h...s...+....h....h....s...h...h...h..l...h...s...hhl........hl.lhp.....................pp...hhtp........hhhh...h.......s.h.hh.h..h.h.hh.......hh............................................................................	0	764	1422	1713
+13074	PF13232	Complex1_LYR_1	LYR-motif-like;	Complex1_LYR-like	Wood V, Coggill P	pcc	Manual	Domain	This is a family of proteins carrying the LYR motif of family Complex1_LYR, Pfam:PF05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.	20.80	18.60	20.80	18.80	20.70	18.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.07	0.72	-3.76	236	283	2012-10-01 20:54:40	2010-08-19 18:36:27	1	8	162	0	201	1849	13	65.40	24	34.50	CHANGED	pplLpLYRpl....LRpu.pp......hsshshp........................h...ppp...lRspF+.........................cs+s......hpD......................p.......pIpph.lp.pupc......................pL...phlp	.................................................tshpLYRpL..................LRpu..pp........................hs.s..hshR...................................pas...pc+........l+..ctF+..............................................cppp..........hpc.................................p.........clpph..hp..cuhp......................pLphh.................................................................................................................................................	1	61	104	165
+13075	PF13233	Complex1_LYR_2		Complex1_LYR-like	Coggill P	pcc	manual	Family	This is a family of proteins carrying the LYR motif of family Complex1_LYR, Pfam:PF05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.91	0.72	-3.55	66	376	2012-10-01 20:54:40	2010-08-19 18:48:37	1	4	227	0	259	553	1	103.20	18	73.89	CHANGED	lhplYR..................plL.+pL.p....h................................................s.hcppl...........ppp...hpp.ppphs....................................................................httthpchpphhpalpsp+...tahph...hppY........p.Ght.hsp-cp..l...................chsuphVshp	.....................................................hplYR....................plL..+th.t........h......................................................................shhcphl.......................+pp...Fpp.pptss.................................................................ttthptthpchpp..hhphlpppp.....ph.ph....htph..................s....hs...pp.....................t............................................................................................................................	0	63	125	203
+13076	PF13234	rRNA_proc-arch		rRNA-processing arch domain	Wood V, Coggill P	pcc	Pfam-B_8473 (release 24)	Domain	Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [1].	21.30	19.20	21.30	19.20	21.20	19.10	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.62	0.70	-5.23	86	683	2010-08-20 10:00:23	2010-08-20 11:00:23	1	18	387	9	414	671	13	215.90	22	22.40	CHANGED	EaMLc+.SFaQFQsst.........................ulPtLEcclpclcpchsshpl......s-.........Esslp-YYcl+ppLpphpc-hRpll.......s+PpasLsFLQ.sGRLl+lpt...........ssp-aGWGl.....Vlsap.++p.st..pt....................................hsspppYlVDVLlps..s..cssstttps.................stshcPspts.-..cuch....pVVPlsL.sslpuISslRlhlP..cD.L+st-s..+pslh+sl.........pElp+R..F.P-G...lPlLDPlccMpIcDssFp+ll+KI-sLEs+LhssPLpsu..scLp..clYppapcKhclppcl+plKcclppu	......................................................E.Mlc+SFhQFQspp................................................................................slsthpc..plp.p.h.pp.phstlth...............c............................................pts...ltpY...aplppplp.p.hp.p.....p..h.p.phl.......hp.st.....hs....l..h.Lp...sG....Rlltlpt...............................................tt.p..c.hs.hGl.....llpht.ppt....................................................................................hhh.shh.........................................................................................hh.h.h....lttlsthhh...h...........p..h.....tt.............ht.....t..hhttl.........................tcl.ph........h..sts....shlcPhps..htl....p.s.thhp.............hh.php.hpphh.t.t.h.hp........s....ph..............t.h..htt+.tht.phpthc.........................................................................................................................................................................	0	147	240	346
+13078	PF13236	CLU		Clustered mitochondria	Fey P, Coggill P	pcc	[1]	Domain	The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport [1,2] although the exact function of the domain is unknown [4]. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane [2] suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast [1]. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre [1]. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure [3].	21.40	21.40	21.60	21.50	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.51	0.70	-4.92	42	412	2010-08-23 12:34:58	2010-08-23 13:34:58	1	64	248	0	310	412	5	207.90	35	16.22	CHANGED	DWN-EaQuh+ElPppolp-RlhR-RhltKlhp-FspsAsc..sAhsllpGplhPlNPp-spp........sphalhNNIFaShu.s-shspapphGG........DcA..AptAuspDLpulphlsph.....D.lsslppLsTsllDYtGpRllAQohlPGlhp....................p...slhYGus-.....................supplhscppFtphl.cphuchh+lKpHpV...h.....t.....hplhsSh-sKGlhGsDuR...pYlLDLhRshPhDlsah	.......................DWNEEhQss....+E....lP.pp.....slp..-R............lhR.-..R.......h.l.K..lhsDFssAAs+..GAhtllc.sp......lhs.lNPp-..pp......................hphalaNN.....IFFShu..hDs.h..spapphGG......................................Dp.A.....AhsAsspD.LpGl+shs.p.h........D.lpG....Las.sosllDYtGhRl.sAQ................SllP..GIhpt.........................................................ptpp.slhYGu.h..-.....................tsc...slh.s.p.......c.a.h.phh.pchuc.L+lptHtVh.................................spps..thcLhuos-sKGllG.s.DuR...pYlLDLhRhhP.Dhta......................................................................	0	124	189	271
+13079	PF13237	Fer4_10		4Fe-4S dicluster domain	Coggill P	pcc	Jackhammer:O26799	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	25.50	24.60	25.50	24.60	25.40	24.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.32	0.72	-4.16	189	7356	2012-10-03 08:56:43	2010-08-23 16:55:13	1	391	3234	1	2292	29622	8087	55.40	30	19.67	CHANGED	thhhs.pt.C.....h.tCt.....tChp.....s.C......P...................................h.httthttthth.ss.p.......................Cht.........................C......s.......tChps.CP	......................hh...hs.cp..C........l...sCs.......hChp..s..C............Ps............................................................................................tshp.t.t.p.p.h.h....pl....ss...s.p.........................................................C.h.p................................................C.....................G...............pChps..CP...............................................................	0	833	1631	2006
+13080	PF13238	AAA_18		AAA domain	Bateman A	agb	Jackhmmer:O27656	Domain	\N	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.82	0.71	-3.83	124	2477	2012-10-05 12:31:09	2010-08-24 11:57:14	1	35	1523	30	881	16173	6513	139.40	17	66.84	CHANGED	IhlsGssGsGKoTluctL.....tct......h.......................thhltchhhptshhhthsph..............tpttthshptht.hhpthtpt.........................tp.h...ll-shhsthh..tphh.hh...........................lhLpss..chhhcRlpp..Rshpt.p.............cptpschhp	..................................IhltGssGsGKo....Tls...ppL...............pcph.............................................................................thhh.h..p.........h...h..p..t...s...h.h..t...t.h.ppt.....................................................t.p.t......t.h..s.t.s...t...h..........h.h.p.thtp...t.......................................................................................................tt.t..t...l..........l....l..-....s....h..h...s...h..h.........t.p.h.h.hh.........................................................................lhLps..s...c..hh.h...cR.hps.....Rs.tp.p.t.p.......................t..................................................................................................................................................................................................	0	254	472	688
+13081	PF13239	2TM		2TM domain	Bateman A, Galperin M	agb	Jackhmmer:O27758	Family	This short region contains two transmembrane alpha helices that are found associated with a wide range of other domains.  This domain may be involved in cell lysis or peptidoglycan turnover.	24.80	22.90	24.80	22.90	24.50	22.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.96	0.72	-3.92	128	506	2010-08-24 13:02:44	2010-08-24 14:02:44	1	11	339	0	207	516	126	80.20	23	53.61	CHANGED	phppApc+l...cch+tFat.HLhsYllVssh..LhhlNh.hs.s.sh.................Ws...........l..a....sh...lhWGlGLhhH..uh.p...s.a......hhhup..pWcc+clp.chhp+	.......................pApc+l...pph...psFhh.Hlhsalllssh....Lhhlsh....hs...sssh.h........................Wh.............l.....a......sh.hsWGluLlhH.ulp...s..a.........hhst....pWppp.php.p.h.........................	0	49	140	187
+13082	PF13240	zinc_ribbon_2		zinc-ribbon domain	Coggill P	pcc	Jackhammer:O26621	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. Pfam:PF12773.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.62	0.72	-4.35	442	1062	2012-10-03 10:42:43	2010-08-24 14:40:20	1	99	704	0	242	1992	209	23.00	39	6.97	CHANGED	hCspCGp.pl.s.c.s.spF......CspC..Gsp...l	........hCscCGp.pl.p.-.s.spF.........CspC..Gpt..........	0	98	197	231
+13083	PF13241	NAD_binding_7	Hydrolase_like;	Putative NAD(P)-binding	Coggill P	pcc	Jackhammer:O27094	Domain	This domain is found in fungi, plants, archaea and bacteria.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.27	0.72	-3.77	422	3188	2012-10-10 17:06:42	2010-08-24 15:53:40	1	33	2756	11	874	5098	3558	109.30	30	31.68	CHANGED	lhl.clps..+cllllGGGpVAt..c+lpsLlp.ts..A.c.l..sV........l.u...Pp.............htc.......................................ph.lp..............h........t........p.........+p.................................................a...........c.sD..................................l.p.....s..........sh..........lVl...uAos-..splNcp..ltp....ts..+.....ph..LsN.ssD........ss...ppss...........hhhPu	.................................lhhpLps+plLl.VGG..G..c.V..A...t....RKsphL..lc..sG...A.c......l..pV..........l.u..sp..............hp...................................................sh.lp...............h...........h........p.........c.t....................................................................a.........c.sp.....................................................L.c.s...............sh........Lll...A.AT...s...-....s..t.....l.....N.p.p....V.tp........sA.....ct......cpl.....h..sN.llD.....ss...ptssFhhPu...................................................................................................................................	0	272	556	743
+13084	PF13242	Hydrolase_like		HAD-hyrolase-like	Coggill P	pcc	Jackhammer:	Domain	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.81	0.72	-4.27	437	8522	2012-10-03 04:19:28	2010-08-24 17:11:02	1	48	4225	45	2343	23735	6396	74.00	26	28.24	CHANGED	s.GKP...s.shhhpt......Ahtth..............................shp..............................pp..........shh.lGDp..sDlhuuppsG..h.ps...lLVho.Gh...pst............pthtt.........h..pssh.l..hss.l...s-h	......................................................................................h.htKP..p..sh.h..hpp........Ahpph.................................................s.h.c................................................hpp............shh.V.GDphhoDl.t.u.ut......p......s.......G.............h....p.o.........l.L....V.h..o....Gh.....tp.......................tth........................ssh..h...h.sl....................................................	0	726	1394	1948
+13085	PF13243	Prenyltrans_1		Prenyltransferase-like	Coggill P	pcc	Jackhammer:O27751	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.50	0.72	-4.04	26	810	2012-10-03 02:33:51	2010-08-25 13:25:01	1	65	544	6	312	4104	349	105.50	17	18.46	CHANGED	lpshlphllspQpp-GuW....s..hs......hs......s........s.hssssthh.tshttt.....t.......ss...sstpul.c+us-alhc..pQps..-Guat...tp...stp...............sh....sp.ssh.hs.sh.hht.thht.........scpp.lc...+ulcalhpp....p.sc	..........................................................................h...hhth.lh..ptQ.....p......-....G.u..W.............h...hp..............hs...............s......................................s...h..s..o...s..h...sh....u.Lt.th.............s.....................ss......ssp.s..t.l..p.....+..u..s.p....aLhs...........p.Q..p.t...........D.........G..u...a.u.........ts.........stt.................................................................h....th....h.....h.....h...........................................................tt.........................................................................................................................	0	121	211	269
+13086	PF13244	DUF4040		Domain of unknown function (DUF4040)	Coggill P	pcc	Jackhmmer:O27316	Family	\N	30.00	30.00	30.30	30.30	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.25	0.72	-3.99	434	1807	2010-08-25 15:48:25	2010-08-25 16:48:25	1	9	1353	0	544	1494	224	71.00	34	10.23	CHANGED	hhlllluulss.lh..t.+s+lsAllhhGlhGhslulhFhhhuAPDlALTQhsVEs.loslLhllslppl..............sphtp	...........h.llhlssu.l..h..h.lh..t..+pRLsullhhGshGhslulhFlhhpAPDLALTQh.lVEs.loslLhlL..shp+LPp...................	0	159	338	455
+13087	PF13245	AAA_19		Part of AAA domain	Coggill P	pcc	Jackhammer:O26587	Domain	\N	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.74	0.72	-4.22	209	2781	2012-10-05 12:31:09	2010-08-25 16:49:56	1	100	1622	0	906	20876	4566	80.60	23	8.66	CHANGED	cAlt.uht......ssl...hllsGGPGTGKT.sslptlstlh........................t...sttlLll..uPoscAsc.pl.tpth...........................h..upolcplh	.......................................t.....t.t......psh.......hll.pGsP.GTGKT.s....s.h....l.p..t.lAhLl.............................................................................tt.......s.p..p..l...Ll..l.....u...s...p.s.h.hc...hl.pphL.........................................t................t............................................................................	0	336	668	820
+13088	PF13246	Hydrolase_like2		Putative hydrolase of sodium-potassium ATPase alpha subunit	Coggill P	pcc	Jackhammer:O26582	Family	This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.28	0.72	-4.03	225	1746	2012-10-03 04:19:28	2010-08-25 17:23:33	1	71	1074	0	530	10781	261	97.10	34	14.14	CHANGED	sLCNpup.....h..p...tt..............................................hhG-.soEsALlph....scph..hts..............................................hpt.....h+...pphp+ltp..lPFsSspKhh..ssl.......................t..............................................sst.......hh.hhKGAPEplLc+...Co.pl	.............................................................................................................................................hLCNcup..h..sptpts.......c..............................................hsG-.soE.uA..L.lcs.....s.c.hh.....hts..........................................................................................................................shs..........h+.......pc..........c...+...l...sp.......lP.FsS...s.p.Kh.....ssl...........................t..cs..............................................ssss....t..hllhhK...GAP.EpI..L-R..Coph............................	0	204	318	445
+13089	PF13247	Fer4_11		4Fe-4S dicluster domain	Coggill P	pcc	Jackhmmer:O26500	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.29	0.72	-11.02	0.72	-4.11	103	12420	2012-10-03 08:56:43	2010-08-25 17:37:53	1	136	2648	60	1943	6770	905	93.70	38	31.84	CHANGED	shhhYLPRlCcHCLNPsCluuCPuu....AlYKRpE...........DGlV.LlDpcpCR....GaRhClouCPY+psaaNapoG..+uEKCs.hCaPRlE....sG.s....ssCscoCsu+hRYhGsh	..........................................h...hhshtC.pH...C..p......c..s...sClssCPsu................Ah.h+cp....................s.GlV..h.ls..p-p.Cl.....GCc.hChhACPas........s.....h...............p.........h................s...............p....ss.....................ps.p.K.Cs..hC......h......t......R.ht...................G............................PsClc.sCs.s...p...AlhhG..h............................................	0	603	1190	1602
+13090	PF13248	zf-ribbon_3		zinc-ribbon domain	Coggill P	pcc	Jackhmmer:O26570	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. Pfam:PF12773.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.29	0.72	-4.63	487	1966	2012-10-03 10:42:43	2010-08-26 11:58:27	1	152	1261	0	583	3186	312	25.60	36	8.81	CHANGED	t.hhCspCGp.p.h...sss.......spFCspCGspl	.........hhCPpCGp.p.h......pss...................spFCspCGppl.....	0	221	418	509
+13091	PF13249	Prenyltrans_2		Prenyltransferase-like	Coggill P	pcc	Jackhmmer:O26856	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-11.04	0.71	-3.67	105	3084	2012-10-03 02:33:51	2010-08-26 14:46:15	1	123	1058	183	1552	4407	373	121.60	19	29.92	CHANGED	lchlhs..t.Qp..sDG...u..as..................h.................tp................tsssshTu.hAlh...uL....t.shspps.......s...............hcch................................hpal.p.p.ppp...sGu..ast..........sst............s..tss....hps.shh..sl.t...sh.......phh..spp......................phhpp....s.....lp.........alhs.hQ....s.......s....s.G.Gaph	...........................................................................thlht.h.Qp....t.s.....G....u...au..............................................s..................tp.........................spsssTs...ts..lt....sL.......s..hhuppp......s....................tpph............................................................hpaL..hs..hQ..........p....s.D....Gu..ahs..................p...........................................t..s.s..t...h.h.s...oh....h......ul..s..ul............thh.s.h.tt........................hpc........u.........hp..........al.hs..hQ......p............c.G.Gat.t..............................................................................................	0	523	955	1309
+13092	PF13250	DUF4041		Domain of unknown function (DUF4041)	Aldam G, Mistry J	gba	Pfam-B_2162 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and viruses, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF10544.	21.00	21.00	21.30	22.50	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.39	0.72	-4.41	57	210	2010-08-26 13:56:30	2010-08-26 14:56:30	1	3	206	0	39	173	8	55.90	33	12.28	CHANGED	KhhlRuFNuEsDsslsKVphsNlsphccRIp+uFcplNKlspt..slpIstpYLpLK	....KhhlRuFNuEs-shlsKVshpNlpshpp+ItKua-tlNKlhcss.slcIsppaLclK......	0	15	26	32
+13093	PF13251	DUF4042		Domain of unknown function (DUF4042)	Aldam G, Mistry J	gba	Pfam-B_2172 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 180 amino acids in length.	21.60	21.60	21.60	22.20	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.07	0.71	-4.82	19	156	2010-08-26 14:01:37	2010-08-26 15:01:37	1	11	113	0	95	151	1	167.50	31	16.22	CHANGED	KVRluALthlpsls+sh-++shaGYWpslhP-s.......ttsttpsoLhshlLpDPss+sRssAlpsluthLpGS+.aLsQAsptc..ssptuFTsFSsoLAshlhplHcsLhhhLppEsssshLsQllKCLulLlpsTPYpRLphGllschlppl+.hlcc...pDsslpVuuLhshshLlu.s.t.hsEh	.......................+lR.uAlhsh..shhcp.c.p+.sl..auYWsshlP-s.............................hs.pstss...........oLhT.hhLp.DP.ssKsRssAhpsLuslL-G..u..+paL.......sh........Ap-sp....................spptuFTsh..Ssplus.lhpLHcsLlhuL............tEss...st..........sLs.pllKsLu.....sLlpssPYpRL.....p.............sLlsplh...ppl+shlpc.........pDsslpsssl.hhthlhus...h...................................................	0	38	54	75
+13094	PF13252	DUF4043		Protein of unknown function (DUF4043)	Aldam G, Mistry J	gba	Pfam-B_2174 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 369 and 424 amino acids in length. There is a single completely conserved residue G that may be functionally important.	21.10	21.10	23.50	22.80	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.73	0.70	-5.46	33	188	2010-08-26 14:03:29	2010-08-26 15:03:29	1	2	154	0	29	134	71	315.30	39	84.63	CHANGED	supsusI.chs-LpK.ssGDp.lsasLhspLsucs.shGspplEGptEsLphhspplpIsphR+sVcss..GpMspQRohaslRctA+stLssahschhDphhhlpLuGsp.s...s......s.ttpsphsthtsNslpAPossRhhhuusssstt.............slsu..sDhholchl-phsthuct......s.thhpsh..hs.sucsh..YVhhlsPtQhssL+sssshtp...W.phtpsshsuspu.psPlFp.GshGhasslll+cht.hshphssuss...............................usssslsRAlLLGuQAlshAaGp...........tuuttatasE.......EphDasschtlusstlhGhKKsRFss..st.....pDaGllslDT	........................................t.sssuPlsRhsDLsK.puGDc.lsFslhppLotcP.shGDpclEG..+GEsLpass.sL+INQuRHhVcuG....G+MopQRohasLtppARshLssahschtDpshllHLAGAR.shhss..phhlshstcscapchhhNsVhsPTpcR+hhuussoshp.............plcu..sDlFolsllDshshhl-phshs....slc.h.sst.....hh..sp-sh....YVlhloPtQhschhososs+p...W.phhstssstu+u.ppPLFc.GpsuMapslll+KhsthPIRFhpusp..hstsp.st........................stphsussslcRAhLLGAQAls.AaGp..................cuGtpFphsE.......cphDhsN+sElulshIpGlKKhRFspcsGph......pDaGVIslDT...........................	0	5	12	21
+13095	PF13253	DUF4044		Protein of unknown function (DUF4044)	Aldam G, Mistry J	gba	Pfam-B_2177 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 56 amino acids in length. There is a single completely conserved residue M that may be functionally important.	20.30	20.30	21.00	21.00	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.48	0.72	-4.80	32	476	2010-08-26 14:04:45	2010-08-26 15:04:45	1	1	473	0	39	139	0	34.90	49	77.51	CHANGED	tp++KKosFpKlThlhVhlMlllTluullhuAluu	.....NGpRKKThFEKlTlhlVllMLlsolhGlhAoAluu....	1	5	18	26
+13096	PF13254	DUF4045		Domain of unknown function (DUF4045)	Aldam G, Mistry J	gba	Pfam-B_2180 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.	21.50	21.50	22.00	21.50	20.90	19.60	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.75	0.70	-5.19	12	108	2010-08-26 14:45:42	2010-08-26 15:45:42	1	8	72	0	88	107	0	241.30	29	23.98	CHANGED	RSoSPTKGLGGFVQSAMMKRSDSVSKRWSAQ.........PsshsRs.sShhSsRsShtustt.ss..s...........sp...........................sRPuSSHSEATlV+psp.cs-h.so.ss.........s-shs+ssLs.+stSpSsssss.....sushs.shssosS+TMD.+RWSP..TKuoWLESALN+P-SP+pKtQ..spp..spWhK-.....RQuRuSVDLGRssShK-......htp.s.Gscspssohouhssh.spp-spsscttps.............s.ts...pt...css.ps...csp.ph.pssEtssppss....................tstthtsPs.hsssststssss.....lsu.....pDsl.s+sKPpoP.l.hDFRANLR+RElsp-posp-E.PEFKNVFGKLRKsEopNYVAPD.LK-NIL+GKAALNuTGGPKKop+VDEhKESILK	...........................................................................K..s.................t...s.....................................................................t..................................................................................s.sso+s.p.+RWSP..oK.u.oWL-sALp+.s.-.Pp..................t............t.....................................................................................................................................................................................................................................s........saRusL+.R............t.....t.t...p..s..EhpslhGpL++scsppahsPD.hKtNIhpGKssLs.osGP..s.hhD-h+-ul............................................	0	16	41	71
+13097	PF13255	DUF4046		Protein of unknown function (DUF4046)	Aldam G, Mistry J	gba	Pfam-B_2182 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 64 and 331 amino acids in length.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.31	0.70	-5.67	13	108	2010-08-26 14:47:10	2010-08-26 15:47:10	1	4	56	0	23	94	4	180.70	41	86.05	CHANGED	IE-IYQEILDGKRpRFPsNTWp-DpcNELARRVT+YLIEslLKW-c--I+psWNopLIlKY+LpGlLpp+YsNSPY+MlNDlYPscFKEWEFpMTPLNFWTKEKALEsLKWTIEEKEpLSspcLLclYupKWLccpKLuuPLphaWsGSPYsMIN-LYPsRFKEWEFpMTPNpFWTKEKALEALKWTIEEKEpLss-QLhplYsl+WLpppsLposCplaWssSPYuMIN-LYPspFKEWEFKhTPssFWTKEKALEALKWTIEEKEKLo-EQLLpVYoh+WllKp+LhTPLhRYWpGSPYA	.................................................pIYpplL-GKpp+FP.shW..tpc..s.p..c.h.t+R...s...hpYLlpphLchp.....pp...I....php..hlhpY+L.hhl....pt.s..thlp-haPp...............................................................................hapsSP...athlssLYP.t.+apc..h....................................................................................................................................................................................................................	0	3	21	23
+13098	PF13256	DUF4047		Domain of unknown function (DUF4047)	Aldam G, Mistry J	gba	Pfam-B_2183 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There are two conserved sequence motifs: TEA and FPKT.	22.00	22.00	30.30	30.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.75	0.71	-4.17	5	74	2010-08-26 14:53:30	2010-08-26 15:53:30	1	1	73	0	3	62	0	125.00	72	47.63	CHANGED	VVTYTEAAFVsETKVQuoISTAIVFPKTIDTLscpAcQHEclIL+sYEsMKpElcs-.SlElLEQplssW+pQREKVssEREALQ+IYTEIEsYYsQlpEsl+sccS-SsKcVLpYVNAGF...ppVK-	.hMTYTEAAFIHETKVt.A.TISTA.IFPKTVDpLhEQAcQHKclILHEYcpMKuKLpsp.SspEIEQAlslW+QGREKIsAEREuLQ+VYppIEpPYNQlQEELKs.NpoESsKQVhsYVNtGF+hVKE.......................	0	0	1	1
+13099	PF13257	DUF4048		Domain of unknown function (DUF4048)	Aldam G, Mistry J	gba	Pfam-B_2186 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is typically between 228 and 257 amino acids in length.	25.00	25.00	29.60	29.60	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.12	0.70	-4.74	14	71	2010-08-26 15:06:14	2010-08-26 16:06:14	1	2	69	0	56	72	0	205.90	30	36.84	CHANGED	HTRTLSLLSPsssss.........ss.sssssssssRsoRpPRSATLP.SV-Rosssps.t......uspso--.hspWRRohPP....PopEALMRTG+QMASDLREGLWTFLEDIRQATVGEEGINATcSRs.......ss...+pssspusSRu..............tsGpsupSsoupSupupssssup.......psop...Sss.-sSFWSEFGIDossQp............tsppspsossssp.......pppppsp.....pss.LDl...D.DNWDsWDTPQP.pKoHTPSSSpS	..................................................HhRsLSLLSs....s..................tps...t....Ptssp.P.Sh-ct....................p.hs.WptshP.....spt-tlhpsG.+QhApDh+pGLWTFlEDIRQATVG-EuI....N..u..s..p..sRs.tt..............tpssspuss+s......................ttsssstspoupu.sp.p.s...stt.............sppsp.......stt.p..sF.Wp-hGhss......................sptstss..st..............................t.pt..................-....................-.ps..Wp.WD.oP...............................................................................	0	8	24	43
+13100	PF13258	DUF4049		Domain of unknown function (DUF4049)	Aldam G, Mistry J	gba	Pfam-B_2191 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 310 and 324 amino acids in length.	25.00	25.00	40.40	40.00	20.60	19.00	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.06	0.70	-5.46	3	501	2010-08-26 15:31:45	2010-08-26 16:31:45	1	1	233	0	2	271	0	263.30	60	58.68	CHANGED	pNsNTAYFGDTDGRVGAVLYALLVSGHIGIRuEGWSLLCQLLKHEDMASsAYc+K........NlKsLaoLLNTRDMILNELHQHVFLKcDAITPCIFLGDHTGDRFSTIFGDKYILTLLNSMRNMEGNKDSRINKNVVVLAGNHEINFNGNYoARLANHKLSuGDTYDLIKTLDVCNYDSEpKVLTSHHGIIRDEE+KCYCLGALQVPFNQMKNPlDPEELANIFNKKHKpHMDD+LFHLIRSNol+STPVYsNYFsNTTDFRPKhEcIFtCGQTLKt......I+QKYGHaGsGVDcsQphDNslMGLNShKpA+scRschhhsSGLSCF	.......psspssYFGDTDGpVGAVLYALhsoGHlGIhtcG.shLspLLphED.s.sshh+c........NsphlhslLNpRDhlLppLp.alhlpcDAlTPChFLGDpTGDRFSsIhGDpaIlsLLpphhs........INcNVhVLAGNHEhNhNGNYhtphsphK..stDTYshIKshsVC.YDsch+lhssHHGIhhD-ppKpYhlGslpVshspMpNshDP.ELAsIhNKKH+thhss+hF+h.Ru.ohts...aspYFssoTDaRPK.EslhtCuQhLt.......IpQhhuHpG.Gscpp.t.ssslhGLNuhctthstph......ShhsC.....................	0	2	2	2
+13101	PF13259	DUF4050		Protein of unknown function (DUF4050)	Aldam G, Mistry J	gba	Pfam-B_2193 (release 24.0)	Family	This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 173 amino acids in length. There are two conserved sequence motifs: IPL and FLVD.	22.80	22.80	23.60	25.10	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.19	61	243	2010-08-26 16:15:28	2010-08-26 17:15:28	1	5	148	0	159	242	0	146.50	25	51.54	CHANGED	hssushch-sssshspp.........................................tcpptt...pp.hpp...p......hhNpGLtlWppRRptWsGscppp................................................................................................................................................................pspthRp.......s.hsas.shYcpLlspspshs..pPIsLu-hl.........chLVsGWcp-.Ghas	.......................................................................................................................................t.t...................................t......t.p.p.pp.p...tptspp..pt.......hhNpG........LhlWpppRptWsGsppp.p................................................................................................................................................................p..ppth+p.........s....hsas.sh..Y-pL.ls.........s..scs.hs..pPIsLu-Ml................chLVssWcp-Ghas.............	0	35	92	135
+13102	PF13260	DUF4051		Protein of unknown function (DUF4051)	Aldam G, Mistry J	gba	Pfam-B_2194 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	90.10	90.00	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.93	0.72	-4.63	5	389	2010-08-27 08:24:20	2010-08-27 09:24:20	1	1	389	0	3	31	2	54.00	83	94.76	CHANGED	MFIAWYWIVLIVLVVlGYFCHMKRYCKAFRQDRDALLEARNKLhRRssEEsStp	MFIAWYWIVLIsLVVVGYFLHLKRYCRAFRQDRDALLEARNKYLNSTREETAEK....	0	0	0	1
+13103	PF13261	DUF4052		Protein of unknown function (DUF4052)	Aldam G, Mistry J	gba	Pfam-B_2197 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 220 amino acids in length.	25.00	25.00	61.60	61.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.49	0.70	-4.90	7	72	2010-08-27 08:59:02	2010-08-27 09:59:02	1	1	71	0	2	52	0	212.20	66	97.78	CHANGED	LMKQLKLHINaHYKAILIFWhVALLIKGssoshDlKsI+luFLpDIhNNPSIAIhhFIVlSsFlIQ.DlFRLAVSFGVTRLQFFIGSlCYIlLQSAhFSFLQllhLQshhYpscshSLGupSlcQFFVQFLhYVTlAshFQssVIFppRFpWIGhulGuhFFlGLsSVhYutsGlKtLshpsotsLlsIP.FIhISIsLhllYhllSuIhIRKVSFE	LMKQLKLHIpapYKAILIFWhVALLIKGshsAscLpGlKluaL.-IhNNsSIAIhhFIVsSVFlIQ.DlF.hsVSFGVTRlQaFIGuICaIlLQSAlFShLQllhLQshhYph.plshGppulpQFhlQFlFYsTlAChFQssllFppRFpWlGLhhushhhhuhsSshYutlGIKtLlFhsstsLl-IPaFIslSIsLhhlYIlhSulFIRKVSFE......	0	0	1	1
+13104	PF13262	DUF4054		Protein of unknown function (DUF4054)	Aldam G, Mistry J	gba	Pfam-B_2204 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 120 and 152 amino acids in length.	22.40	22.40	23.20	22.80	21.40	19.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.39	0.72	-3.79	59	275	2010-08-27 10:40:30	2010-08-27 11:40:30	1	1	248	0	36	227	20	106.50	27	80.09	CHANGED	F+ttaPpFss...hP-stlphhls.A.phhlssp.........phuc.hhppuhtLhsAHhhsLsttstt........sus.ssu..hhoStssGplSlS.hssssssss.shh..hspTsYGppahpLhp	............................................F+ttaPpFss...............hscsplphhls.A.s.hlsps..........thsc.hhthhhtLhsAHhhsLtstsst......................................ssutssu...shoS..cosuplSlS.assss....s.....tss.ts..a.....aspT.YGtpahpLh...........................	0	6	22	28
+13105	PF13263	PHP_C		PHP-associated	Coggill P	pcc	Jackhmmer:O27523	Domain	This is a subunit, probably the alpha, of bacterial and eukaryotic DNA polymerase III, associated with the PHP domain, Pfam:PF02811.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.61	0.72	-4.46	143	736	2012-10-03 00:45:34	2010-08-27 12:03:46	1	15	540	9	305	732	62	49.30	25	16.25	CHANGED	spsNccAtphAcchslPhhuGSDAH.hspplGpuhThh.......stshp.....s...c-llpul+cGps	..................s.phApphs.lPhlsuSDAH..thp..plG..psas.h........................s....tthhthlht......................................	0	98	213	275
+13106	PF13264	DUF4055		Domain of unknown function (DUF4055)	Aldam G, Mistry J	gba	Pfam-B_2501 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 140 amino acids in length.	25.00	25.00	27.90	27.70	23.70	22.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.59	0.71	-4.08	30	180	2010-08-27 11:19:37	2010-08-27 12:19:37	1	2	157	0	27	167	145	136.70	29	31.58	CHANGED	PLLsLAplNltHapsSADhcp.lahsupPphhlsGh..ssp..........tslpl.Gupush.LPp.sus.htalchousuls..+pshcchEspMhphGA+llppssss.cTuspupt-pssppSsLtshssslp-AlspuLcasApalG	....PLLsLAplNltHapspuDhpp.lahsupP.hhhpGl...spp........................pslsl.Gupssh.L....sp..s...us.ht.....alptsusult..+pshcchcspMhphGA+..l.lppssss..couspspt-pssppSsLtthssslp-AlspALphsAcah.............................	0	4	12	19
+13107	PF13265	DUF4056		Protein of unknown function (DUF4056)	Aldam G, Mistry J	gba	Pfam-B_2502 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 355 and 380 amino acids in length.	21.10	21.10	22.10	71.80	20.70	19.50	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.70	0.70	-5.40	27	134	2010-08-27 13:34:41	2010-08-27 14:34:41	1	1	128	0	22	109	0	263.80	52	72.18	CHANGED	hsshs.ls.sPpGLRPCCAFGYsL+sclhGlPVPFYplsNVl-s-sLGpH+YNDuhhus...susLlG..lusEpNGLlYTp+GGFIDlAHVRDTADhThYLFopIhs+LGppaplsLssELusRpIpa.ps...ssPhssp-RasLoAaLAApLAFpLAtWHEIAQWYGapSVsGFsEtlSAFSPEDLYSNhLGA+LAhslILpupshShptaspuhsphL.puLppLtAhscspT+ptFcplDGhWWsSp+RlP-KaLVL+RcYclupsRhPshsstp	..................s..ssP..GLRPCCAFGYsL+splhGlPVPFaplsNVl-lDsLGtH+YNsus.uh...ssuLlG....LScEpNGllYTcRGGFIDhA............HVRDTADhThYLFpplhspLGp.thplsLssELtsRpIpa..ps..o..sslsscERhpluA.lAAalAFpLApWHEIAQWaGhpSVsGFsEtsSAFSPEDLYSNhLGA+LAhsllLs............s.stspppaspshsphLcptLpcLtAps.pshTptphppLDGhWWsSpRRlP-KaLlL+RcYcLu.shLPs.ss.s-.......	0	2	7	16
+13108	PF13266	DUF4057		Protein of unknown function (DUF4057)	Aldam G, Mistry J	gba	Pfam-B_2503 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 279 and 322 amino acids in length.	21.00	21.00	33.20	23.10	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.98	0.70	-4.95	13	114	2010-08-27 13:36:17	2010-08-27 14:36:17	1	7	22	0	65	120	0	222.50	44	87.59	CHANGED	RuTPVRKPH..TSTADLLoWs..EsPPssus.....usus.sutRsHQPSDGISKVVFGGQVT-EEAESLsK..RKPCSuaKhKEMTGSGIFussucs-uuEsuuuss.ss.KTslRhYQQussuI.SQISFupEESVSPKKPTSlPEVAKQRELSGTLcoEuDsKhpKQlSsAKsKELSGHDIFAPPPEIpPRsh.ss..Rthth+tshshucsss+shppushhsssAGu.Sph.hsp-sVlKTAKKI.asQKFsELTGNsIFKGDs...sPuSAEK.sLSsAKL+EMSGSsIFADGKu...poRDYlG.GVRKPPGGESSIA	....................................................slRtsH..tsTusLL.Ws.................................ss.ssh.sh.........pPu.tslp.hhh.Gu.lopcEspsLsK......+K.CSs.KhKEhTGSGIFsttupstss-su...sss....+Ts.+.aQth.ssl.SpISFut-tslSPKKPoolsEVAKQRELSGThpo.-s..-sKhp.+.QhSpAKsKELSG.psIFuPP.-..s+s......................t.t....t.........s..ss.....hs.p-sshKT.uKKI..spK..ht..-L.oGN.........sIFK.tD....ssuoA.E.K...LSpAKL+EhoGssIFADG.Ks....sRDhhG.GhRKPPGG-SSIA..............................	2	13	45	55
+13109	PF13267	DUF4058		Protein of unknown function (DUF4058)	Aldam G, Mistry J	gba	Pfam-B_2520 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 244 and 264 amino acids in length.	25.00	25.00	39.30	33.10	16.40	15.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.76	0.70	-5.25	21	75	2010-08-27 13:37:48	2010-08-27 14:37:48	1	3	27	0	25	78	0	216.80	37	96.42	CHANGED	MtsPFPGMsPYLEpPslWP-VHppLIssluDtLsPQLpP+YcssI-cRlYhtsspps...lllu..l..PDVsVhcpp..........ssssssuss.ssspPlsVslshs-.l+psaLElR-Vss.ppVVTsIElLSPsNKRsGcGRt.sYp+KRpclLsStTHLlEIDLLRuGp.....shPh.hsshstucYpILlSRuscRPpA-lYshsLp-PlPshslPLpssDs-shlDLpsllpplYc+AuY-htIDYp...ppPsPP.Lssc-ssWlcphL	......M.sPFPGMsPYLEpsthWs-VHptLIsths-hLtspltPpYhstlp.hlh.tt..pts.......hhht..lPDlsVhppp.................ssssssss.s.stP.hslth.h...s..h+pthlElRplts.tplVTsIElLSPsNK+sG.spt.tYppKRpplhtS..sHLlEIDLLRtGp.................h...ss...ssYhlllSRupcRPt...s-las..hsLppslPshslPLp..Ds-shlsLptllpplYccutYch.tIDYp...p..s.Ps.Ls.p-.tsWlpth.......................	0	7	23	25
+13110	PF13268	DUF4059		Protein of unknown function (DUF4059)	Aldam G, Mistry J	gba	Pfam-B_2521 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DKT sequence motif.	25.00	25.00	43.60	43.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.41	0.72	-3.79	11	344	2010-08-27 15:00:50	2010-08-27 16:00:50	1	1	341	0	20	91	0	69.40	64	96.52	CHANGED	MLlpIFuLYlpGLlLuslhllllullWlhaRAhp+hDKTu+ERQuaLYDhLMIuIhTIPILSFAhMuILLVl	..MLlplFSLYhcuLILToILVLIhLGIWIGLRAhSGVDKTA+sRQAHLYDMIMIGVLllPVLSFAVMSLlLVF.	0	1	3	11
+13111	PF13269	DUF4060		Protein of unknown function (DUF4060)	Aldam G, Mistry J	gba	Pfam-B_2524 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: VEVV and SYVAT.	20.10	20.10	22.70	25.00	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.38	0.72	-4.05	7	128	2010-08-27 15:01:51	2010-08-27 16:01:51	1	1	118	0	14	64	0	72.90	57	90.07	CHANGED	hI.RucpsPlthhAscsALstHhptYG-.GRQth.ssYolthcus+lsVEVVsR+pSYVATsMsGsR+LppLPG	.hI.+.uc.ps..thhsscsAlstHpcpaG-.uRQtasosYpVhhcss+VsVEVVsRppSYVATsMIGsRpLppLsu......	1	0	3	9
+13112	PF13270	DUF4061		Domain of unknown function (DUF4061)	Aldam G, Mistry J	gba	Pfam-B_2526 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 90 amino acids in length. There is a conserved AFG sequence motif.	21.90	21.90	21.90	22.90	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.92	0.72	-3.89	14	156	2010-08-27 15:03:06	2010-08-27 16:03:06	1	3	79	0	89	134	0	85.20	58	39.73	CHANGED	VsDV+cME+uLLsLLsDFHSGKLpAFGpsCohEQMp+lRE.QEpLA+LHF-Lsspt-chs-c...........ttpppspuppNMc+LlppLEpLS.SIpK	..........VoDVpEMEpGLLsLLNDFHSGKLQAF.G............p-C..S..hEQMEHVR-MQEKLARLHF-L.sphE-....sE-...............p++stuDpNl-pLLssLEpLs.SIpp................................	0	20	27	54
+13113	PF13271	DUF4062		Domain of unknown function (DUF4062)	Aldam G, Mistry J	gba	Pfam-B_2536 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.	21.90	21.90	21.90	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.65	0.72	-3.96	28	368	2010-08-27 15:04:52	2010-08-27 16:04:52	1	88	282	0	170	346	35	85.70	28	9.79	CHANGED	plFlSSTapDLp-ERpslhpsl.hchsahPhGMEh..F...sAu.DccphchhpchI.DcsDhYlLIlGsRYGShs....csu...hSaTctEY-aA	................................plFlSSTap..D.hptE......R...p........tlhc........s...l........hp..........h......s...........h.hs.h..th.Eh.....h.................ssp..sppp...hc.ls...h....cpl.cpsD......ha.....lh.llGsRYG.hs.......t.ps...................hSh.sp.Ea..A................................	0	73	110	140
+13114	PF13272	DUF4063		Protein of unknown function (DUF4063)	Aldam G, Mistry J	gba	Pfam-B_3026 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 95 and 123 amino acids in length. There is a conserved RRA sequence motif.	22.10	22.10	34.40	31.50	19.10	21.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.47	0.72	-4.24	16	129	2010-08-27 15:06:18	2010-08-27 16:06:18	1	1	114	0	24	92	1	88.90	52	81.40	CHANGED	sRLssallsullLLhslullSPQQ...LPVllYKLSLlsLAAlsGYWLDRsLFPYARPuuYL....p......ctssh.hupu-aPls...pGYphlFsAAhLRRAlIVu.ushLuVuLG	..........PRLouWLlsollLhulIu.hsSPtQ...lPVVlYKLoLloLuAVLGYWLDRSLFP.a.A.RPsuah....h...............................................................................	0	6	15	20
+13115	PF13273	DUF4064		Protein of unknown function (DUF4064)	Coggill P	pcc	Jackhmmer:O26620	Family	\N	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.74	0.72	-3.90	50	1109	2012-10-02 01:14:40	2010-08-27 16:08:03	1	4	408	0	62	435	1	101.60	24	57.04	CHANGED	KRTsEhlLulIGs...Ilu....ll...huhhhlh...l..u.h.h......u.s...........tp....h..........................................hhhshhullhsIl...uI......luull..lp+....cs..p...luGllhlluullslls	.....................RhsEhlLuh...Iuh...llt....ll...hslhshh...h.h.hl......us................sshtpphttphs..t..................sp.hhshhpsh.h.hslhlhh.l.l.shll....uh......luhl.t...hpt....pp.+..luGlLhlIuuIlsh..s................	0	17	32	58
+13116	PF13274	DUF4065		Protein of unknown function (DUF4065)	Bateman A	agb	Jackhmmer:B5ZAK8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and viruses. Proteins in this family are typically between 155 and 202 amino acids in length.	25.70	25.70	25.80	25.70	25.50	24.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.83	0.72	-3.35	264	905	2010-08-27 15:57:42	2010-08-27 16:57:42	1	8	726	0	195	777	25	106.70	22	56.07	CHANGED	LpKLlY.a.upsht....lth..s....p............s.......lh.s..-ph.pAapaGPV.......h.....p...lYpph+.........tht.....................................................lspppt..c....ll-...pl....hppau....ph...su.hpLpch.oH.....................t.ts.W.........pps	...................LpKLlYaupshtlth.hs...c...................s........Lh.s...pph.pAWpaGPVhsp..........lapth+.........tht......................................................................p.pplspppt.....c.........lls...pl....hppau.......ph..............ss.hpLtch.oH.tp.ts.W...h............................................................................................	0	85	142	174
+13117	PF13275	S4_2		S4 domain	Bateman A	agb	Jackhmmer:B5ZAQ9	Domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.95	0.72	-4.38	202	2674	2012-10-01 23:15:27	2010-08-27 17:10:54	1	5	2633	1	435	1579	178	65.30	38	73.24	CHANGED	lpl.ps.-aIpLsQlLKhssllsoGGpAKhhlt-s..tVtVNG-sEsRRG+KlhsGDhVph......s..spphplh	......................l.p.paIpLsphLKhtGlscSGGpAKhhls-s..pVhVNGp..lEoR..RG+KlhsG.DhVph...s.stphpl..............	1	129	267	362
+13118	PF13276	HTH_21		HTH-like domain	Bateman A	agb	Jackhmmer:B5ZBQ5	Domain	This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.02	0.72	-3.96	515	11498	2012-10-04 14:01:12	2010-08-27 17:18:47	1	58	2749	0	1982	9551	1161	59.50	26	23.43	CHANGED	p....h.c.p.t..h.h.pt.............Ipplap...pp...pt...........pY...GhR+l.pt.tL.c.....c................p....h..t...h........ls+++VtRLM...+.p.hGL....pu......h.h...+..++t	...............................ttp......l.p.pt......ltplap....cp...pt...........sY...GhR.+lt......t..tL.p......c................p..........t...h.......ls++.+VtRLM...+.phuL....ps.....p..h..+.tc.....................................	0	514	1189	1570
+13119	PF13277	YmdB		YmdB-like protein	Bateman A	agb	Jackhmmer:B5ZC04	Domain	This family of putative phosphoesterases contains the B. subtilis protein YmdB Swiss:O31775.	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.62	0.70	-5.36	140	1315	2012-10-02 19:15:56	2010-08-27 17:30:23	1	3	1256	8	347	881	1521	250.70	47	94.97	CHANGED	LFlGDlVG+sGRpslpcpLPpL+cch.plDhllsNGENA.A.uGhGlTtchsccLhssGlDslThGNHsWDp+Elhsal-p.ps.+........llRPhNaPp....ssPGcGht......lhcs..sGp+ltVlNlhGR.lFM......pshs....sPFpsh-pllp...ph.......ttp..sshl......lVDhHAEATSEKhAhGaalDGRlS......sVlGTHTHV.TADppILPsGTAYlTDsGMsGsa.cSVIGhcp-tslc+FlothPp.R...FpsApG..ps..pLsGlhl-hD-pTGcAtpIphlp	.................................................LFlGDlVGcsGRcslpphLPpL+pca.c.shsIlNGENA......A......s.GpG...lT.....ccIhcpll.csG.lDslThGNHsWDp..+.E.lh-.FI-c.t.p.+........llR.......PANaPc......ssP....Gp..Ght........hlps.....Ns....tcl..uVlNL.GR....sFM.........s.sl-..sPFc.ps-pllpph..........pcpsshI......hVDFHAEsTSEK...A.........hGaaLD.....GRsS......AVVGTHTH.VtTADpRIL.....P................pGTAYlTDlGMTGs.Y.DullGhc+-tllc+FlTslPp...+...hps.s.p.G...c..s..hLsGVll-lDc.p..oG+ApcIcpI................................................	0	143	256	301
+13120	PF13278	DUF4066		Putative amidotransferase	Bateman A	agb	Jackhmmer:B5ZBC5	Domain	This domain contains similarities to other amidotransferase families such as Pfam:PF00117. Some members of the family lack the likely catalytic residues.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.82	0.71	-4.98	51	5657	2012-10-03 00:28:14	2010-08-27 17:42:27	1	16	1638	20	2096	9111	779	160.80	25	54.62	CHANGED	Lsa-.GFs-lDhhhshslLspsp........t.t...aplplsusssp.Vp..........Sh.sGlsl.tsptsLpp...sspsD.sVL....lsuGhp.....pthssc.stlhspL.phc................stt...phluutCoGshlLAchGLLsshsAsTchpspshlppttspVh...sp.asssG.........slsTAG.Gsluuh.Luhallt	......................................................................................hhsshphhshsssh-.sh.thss..................................t....ha...p.h...p...l..h...u......s......s.....s......s...l.p.........................................s.s....s.....G.....l....p.....l......s..s....t.s..h..ss................hs..p.....s...D....h.....ll.................V..s.G.uhs....................t.t.h..ts...t....tl....l.....s.....h....l...p.p.tt......................................tpu.......thlsulC.o.G.u..a.l.L.At.A.G.L.L..c...G...+..c.A..T.....T.......H.......W............t..........h............h.......s.......t.......h...t..p...t......a........P....p....l....p....h...t...............s...t.....h...a...l....p...D.u............................................................s.lhTu.u...Gss...A..ulDhsLtll....................................................	0	461	1105	1633
+13121	PF13279	4HBT_2		Thioesterase-like superfamily	Bateman A	agb	Jackhmmer:Q7P2C3	Domain	This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily [1].	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-11.44	0.71	-3.66	179	4845	2012-10-02 20:54:35	2010-08-31 15:04:51	1	19	2807	37	1526	6021	3343	126.80	18	76.66	CHANGED	Vt.s-.hDh................................t...Hh....s..sspYl......................t.h....hpt.up..............phht...............hsh.....thhttt...............th..................uhhhsps....plpah..p........................plp.hs-p.h.........lp..............hpl..hs........hsppphthhhph..............hp..............tsp...h...............Apspthhhhh.shpp.................................................................................ssshP......pt............ltptl	..............................................................t-.hD............................hhs.Hl....s....NupYh......................pa....h-p.ARh...............................................................phh.p..................phsh..........hp.hptp....................................s.h.............................shl.lsch........phpYh..p..........................lt..hs-p..l..............plp.................spl.....hp....................hssp..php.hp..hp..l............hp.................................ssph.....s.........................................up..uph.h..hlhl..-hps...p................................................................................................hs.....................h.h..........................................................................................................................	0	432	883	1254
+13122	PF13280	WYL		WYL domain	Bateman A	agb	Jackhmmer:Q7P457	Domain	This presumed domain is around 170 amino acids in length.\	\	   It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. There are a number of proteins that contain two tandem copies of this domain such as Swiss:Q47P13. This suggests that this domain may form a dimeric arrangement.	25.80	25.80	25.90	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.14	0.71	-4.39	746	6059	2010-09-01 09:50:02	2010-09-01 10:50:02	1	38	2680	0	1655	5249	711	156.10	17	51.55	CHANGED	p.h...l...p.........t.......lt....pAltppc...tlph.....pY..ps..................................pptp.....p................R.p....l..........c.........PhtL.h..h..p..p..s..p..WYL..hu....h........s..p.............................p.......c...........p.........s................h..R...........tF+..lcRl....p..s..lp....hh..s.....p..................................ph..p.......hs...sh....c.......l......p........................p..hh.p......p........h..h.....t..hht................t...hp..l......pl............c..h.........s...sps...sph........lh....p....p.......hh.......t....s.............t.p..........................lt...............p.....ps..........ss.t.h........h.....hp.h...p.....h..t.s.....p.....t.....h.h.thlhua.G..s.p..lcVlp....Ptp..L+ppltpphpp.hh	..............................................................................................t..httltpAltppp....hlph.....p.Yps.................................ttptp......p......................................R.p...lp.......PhtL.hh........t...s..s...p.....WY....L..hu..a........st............................................................p......c.............p...........p........................h..R.........sF+..l..sRI....p..s...lp....hh..s..p.............................................th.t..............t......s.........h..t.................................p..h.h.p......p...................t.....................ph..hl............h.h.........t....th......h..h........h....t.............h..................t......................................................h................t.......t..........pt.......h..........h.....hp.h........h.....t....................h..h...h...l...ht..hu...............t..htllt.....P.t....lht.hht.ht.......................................................................................................	0	652	1199	1458
+13123	PF13281	DUF4071		Domain of unknown function (DUF4071)	Aldam G	pcc	Pfam-B_2008 (release 24.0)	Family	This domain is found at the N-terminus of many serine-threonine kinase-like proteins.	24.10	23.40	24.60	24.10	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.23	0.70	-5.61	14	275	2010-09-01 12:57:33	2010-09-01 13:57:33	1	13	141	0	144	258	14	309.10	37	31.02	CHANGED	LhYcLGVRESFphppNIlLas-ss.p...-sh.tl+..h........ushphlPYhlsspu.......thhps.....pttcthh..s.th..sh.shsLsstlhpLlpss.phppstah+Ephhs-lRpA...R-phsu..cpLpctLpclct+LDssplLos-IlhsLhLSYRDlQDYsuMlcLV-cLpsls.h..lssss.lpapYAFALNRRNpsGDREKALpllhph.......lppccshusDhhClhGRIYKDhFhcSshpcpso.....LcpAIcWY+KuFEsp.PstYuGINhsTLLhhsGpcFpps.ELpplu..hhLssLlG+KGsLsphpDYWDVATahElulLApDhtKulpAuEpha+L+sPsWYL+SThpNIpLlcch++phpt....s.c.phhpFWh-h	.....................................................LhYHLGVRESFsMtpNll.Lhppts......th.uL+..h..........usYhhlsYhlssps...............phhsspst.h.....pthsphh..s.........t........hhsL.sRhhp..lLpsh.php..S..p..t..ah+.E.phhpD.lRpA....Rphapu..........p....pLtttLtclptRlD.s..c.lLos-llh..slLLS.YRDlQDYsuhlcLV-sLphlPshc.hsp....p.pl..pFpYuFALNR...R....N..sG.DR...t+ALplhl.h............lpp.p...tp.....sssD..hhCLsGRIYKDh...Fl.cS..sh..p..Dsps..............h-pAh.pWY+...KuF-hp..s..........sh...auGINhAs..L...Ll......huG.......p.....p...Fc..............so.E.............Lp.p.lG........hpL.ssLlG......+...KG.....s..........lpph.ppYW-VuhahtsslL....As...Dhhc.slpAuEpha.KL.p.sPhW..........Y.Lc.S.....hhpslhlhp+Ftt..t......s...phhpFWhc....................................................................................	0	29	48	89
+13124	PF13282	DUF4070		Domain of unknown function (DUF4070)	Aldam G	pcc	Pfam-B_2005 (release 24.0)	Domain	This is a bacterial domain often found at the C-terminus of Radical_SAM methylases.	21.60	21.60	21.60	21.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.74	0.71	-4.66	55	231	2010-09-01 13:08:55	2010-09-01 14:08:55	1	4	185	0	116	262	53	141.90	28	27.44	CHANGED	TsLWcRLc+EGRLh.......tpssssQ.sshhNFlPshPh-clsptYhcshhpLY-PcpYhcRshphhhphss...sptph..........shtsL+AlhplhW+.Glhp.cpRhpFW+hLhshlh+pPpsl.hhlslsshucHFhcap.phlpcplcppl	...................TsLacRLc+EGRLl.................pstsssp..s..sthNFlP.p.hPh-clhstYhcshtplYsP..ctahcRhhphhtphtss....t..h.t..................s.htsl....puh....hpl.....ha+......G.l....ht..ctRhtFW+hhhthlh..+...s...P..t..h.hthhlshshhscHahpat.p.shpt.t...h...................................................	0	33	79	103
+13125	PF13283	NfrA_C		Bacteriophage N adsorption protein A C-term	Aldam G	pcc	Pfam-B_2015 (release 24.0)	Family	The function of this domain is unknown but it is found at the C-terminus of bacteriophage N4 adsorption protein A, in association with an N-terminal region of TPR repeats.	25.00	25.00	34.10	45.50	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.88	0.71	-4.91	14	355	2010-09-01 13:23:58	2010-09-01 14:23:58	1	21	350	0	31	204	0	175.00	65	19.09	CHANGED	sps.susTGhsTsQGulGsRaKPlpstNLllssp...RhhtlG.shutsDWLLRhuYS....ss.Gs..DL+VstPsWhohplYsEuuaalppsphh.sssEuchG+oaRlsuhss+LslhPassluusaDostssp...hAlGuGsGlshRaWFREscYsAPtSalDlolQYRhpLsss-.RucGlhhcAs	.................G.ENGVMMPVKNPMSGTGLRWKPLRDQIFFLAVE................QQLPLN.GQNGASDTMLRASASFFNGGKYSD......EWHPNGS..GWFAQNLYLDAAQYIRQD.IQA.WTADYRVSWHQKVANGQ...TIEPYAHVQD.N.........G....YRDKGTQ.....................GAQLGGVGVRWNIWTGETHYDAWPHKVSLGVEYQHTFKA..IN..QRNG......ERNNA....	0	2	9	18
+13126	PF13284	DUF4072		Domain of unknown function (DUF4072)	Aldam G	pcc	Pfam-B_2021 (release 24.0)	Family	This short domain is normally found at the very N-terminus of Hyrdrolases Pfam:PF00702.	21.90	21.90	21.90	23.70	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.11	0.72	-3.78	23	106	2010-09-01 13:49:34	2010-09-01 14:49:34	1	2	105	0	40	85	2	47.80	41	16.54	CHANGED	LllQSss.LusschcsLssLupusplpp.lsspAhRltsA..ssspRs-lc	LVlQSsuPLSsuHt+sLsALucusclst.lsspAhRltsA..ssupRsDlD......	0	5	19	30
+13127	PF13285	DUF4073		Domain of unknown function (DUF4073)	Aldam G	pcc	Pfam-B_2039 (release 24.0)	Family	This family is frequently found at the C-terminus of bacterial proteins carrying the family, Metallophos Pfam:PF00149.	25.00	25.00	25.30	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.92	0.71	-4.80	8	102	2010-09-01 13:49:58	2010-09-01 14:49:58	1	6	101	0	3	91	0	136.80	62	22.17	CHANGED	LNLPDWAGKKKIsG.GDcKGFTVVNTGGIETGWMSAGPNGGEKTAPDGhSFKQGLQVKAYGNDVVVTAYDYKRDKsIKKLLISDuKIAQMAPDVTADDsKNVIVGATEYMEYoVEGTNEWpTYs.usPPKFDGDKlVYVRHKGEMNLEPGLTQLLRFSs	..................LNLPDWAGKKKItG.G.Dc...KGFTVVNTGGIETGWMSAGPNGGEK.TAPDGYSFKQGLQVKAYGs.DVhVTAYDYKRDK-IKKLLISsSKIAQMAPN.VTADDoKNIIVGATEYMEYSl-GTsEWhTYs.uNPPKFDGDKhVYVRHKGEMNLEPGLTQLLRFS.s..............	0	1	2	2
+13128	PF13286	HD_assoc		Phosphohydrolase-associated domain	Aldam G	pcc	Pfam-B_2016 (release 24.0)	Domain	This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.30	0.72	-3.71	344	2449	2010-09-01 14:47:52	2010-09-01 15:47:52	1	4	2227	6	684	1967	1173	91.00	22	22.24	CHANGED	lshssp.httthptLKpFlapplYcpsplpphpt+uppllpcLFph....a...hs......c...sp.hLPspaptth....ppssp.........tptRllsDYIAGMTDpaAlchapc	.......................................................................................h..hs.thttththL+phhhphlhpp..p.h..th.p.h..p..s.ppllppLhch....h.....hs...........................................c...sp.hLs..t..p..h.t..thh...............................pttt...................t+hRllsDYIuGMTDpaAhc.app............................	0	235	468	581
+13129	PF13287	Fn3_assoc		Fn3 associated	Coggill P	pcc	Jackhmmer:O26995	Repeat	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.10	0.72	-3.88	342	282	2012-10-03 16:25:20	2010-09-01 16:25:02	1	69	219	0	75	1442	337	63.70	33	7.78	CHANGED	VsLo.o..............spsA.....sIYYTlDGosP....T.s........pSsh.......Y...........s.sPIhl......sp.........ss.s...............................l..KAhAhcpu....hssSslsohsa	....................pLp..o..t...stsu......pIaY.Tl.DG.S.sP.......s..p.............................pSht.........Y...........................s..ss.I.hl......sc......ss..s...................................................................................................l...KAlAhcpu.....hppSslsoh...........................................................	0	29	55	68
+13130	PF13288	DXPR_C		DXP reductoisomerase C-terminal domain	Bateman A	agb	Jackhmmer:Q7P3U3	Domain	This is the C-terminal domain of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme. This domain forms a left handed super-helix.	27.00	27.00	27.20	27.30	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.49	0.71	-4.10	236	3405	2010-09-01 15:25:30	2010-09-01 16:25:30	1	7	3273	79	826	2642	1652	119.10	39	30.61	CHANGED	LGsPDMRhPItYALsaPcR..h.........s..s......ss.ptL.Dhs..pl.up.LsFc.pPD....hc+FPsLpLAh-Ahct..GG..shs.slLNAANElAVpuFLpt+IsFh-Iscllcpslpp..........hps.t..................ssL-sllpsDphARphA	............LGsPDMRhPIuaulua.PcR...l..............s...s......s.s.psL.D..hs......cl....u........s.Ls..Fp.tPD....hc+FPsLcLAh-Ahct......Gs..shs.slLNAANElAVsAFLsp.cItFh-Isplltpslcp...............hsht........................sssl--lLp.hDt.ARch.......................................	0	289	560	710
+13131	PF13289	SIR2_2		SIR2-like domain	Bateman A	agb	Jackhmmer:Q7P447	Family	This family of proteins are related to the sirtuins.	24.50	24.50	24.50	24.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.94	0.71	-4.31	164	1624	2012-10-03 09:55:27	2010-09-01 16:29:03	1	38	1214	0	458	1490	86	152.60	17	27.46	CHANGED	ptllTTNYDsllEpuh.....tptstthh...........................hhspshtt.....................pssphhlhKlH.Gsl............t....s......................psl.llopsc...........Y...tphh......................psh.htphlp...shh.t...sp.....sllFl..GaS..hsDs.slppll....pplhpphss..............pt....ahlh.pst.................tttpt......hhpphslphl	.............................................h..llTTNYDphl.E...psh...........pptshth..........................................h.hpsht........................tpthhtlhKlH.Gsh................................................................................................psl...ll..o..p..s.c.................................Y....tchh........p..........................................................ps...ht..phlp.........shh..p.....sp......sl.lFl..Gao...h..s..D...plp..t..lh...pphhpphtp................h.........ahhh.tt...........................................................................................................................................	0	165	285	360
+13132	PF13290	CHB_HEX_C_1		Chitobiase/beta-hexosaminidase C-terminal domain	Coggill P	pcc	manual	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.68	0.72	-4.19	268	225	2012-10-03 16:25:20	2010-09-01 16:33:34	1	57	161	0	67	1534	350	68.50	26	8.39	CHANGED	sssG.php................st..plslps....sssss.....sIhYThD.GosPoh.........t...S......hY...............t...............s..l.l......t.ss.....ss....l+shuhsss.tps..u.tlh..o	....................t.............pstlplss............sss.ss.....pIaY.ThD.G.o.pPoh..........................p.......S...........hY..................p..t..................................P....lpl..................s..ts........................ss...............lcshshp.s.sp................................................................	0	33	48	57
+13133	PF13291	ACT_4		ACT domain	Bateman A	agb	Jackhmmer:Q7P344	Domain	ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.22	0.72	-3.64	182	5583	2012-10-02 00:29:19	2010-09-01 16:38:22	1	27	3945	4	1173	4363	2094	78.80	25	11.21	CHANGED	sspp.....apsslplpu.hDcpGlLs-lspslupp.psslps.lshps.........pthsphplslpVpshppLpplhppl+plpsVhpVpR	..........s..tta.splclpu.hs.R.pGlLs-lspslusp..psNlhu.lsscsp..p....sphushplslp...l..p..s....h..p....p.L..spllp+l.+plss.VhpVpR........................	0	347	739	993
+13134	PF13292	DXP_synthase_N		1-deoxy-D-xylulose-5-phosphate synthase	Mistry J	jm14	Jackhmmer:Q7P481	Family	This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6).	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.84	0.70	-5.46	331	4453	2012-10-02 16:07:47	2010-09-01 17:03:14	1	13	3512	8	1043	7165	5251	238.80	43	43.01	CHANGED	L-pIssPpD.L+pLshppLtpLApElRphllcsV.Sp.....oGGHLuuNLGVVELTlALHhVFsoPc.D+llWDVGHQuYsHKlLTGR+.-papolRphsGlSGFPcRsESt.aDsFssGHoSTSISAALGhAhA......pc.l.p....G...p.........s.....ppVlAVIGDGAhTuGMAaEALNpA..Gph.p.p..sllVlLNDN-MSIu...........NVGulu.paL...sclhs...sth...Ypph+ptscphl.p.....hh.......hhphhc+h....ccshKshh...h....s......slFE-hGhpYlGPlDGHDlppLlpsLcps+......s.....h....cG.PlllHVlT	.........................................................................................................................ttlpsP.t-L+.tLsh......ppL..pLu...p...ElR.p.h...l.l.p...s.V...S.p.....o.G.G..H.....huusLGs.........V.........E..L.........T.........l......A.....L.........H.........h.........V.........a..........s..........o..........P.........h........D.p..llW..D.....V.....GH....Q....u.......Y....s.....H.....K...I......L....T.....G.....R......c........c....p.....h.....t.....T......l....R......p.h.....s....G.......l....s....G...F....s....p......R.......s......E...S.......p..a.D......s......h.....s.....s.......G.H.....o...S..T.....S....I.SA......u.l.GhAh.A......tc..hp....G..p....................p.....cps.l.uV..I..GD...GA............l.TuGM.AaE.A.h.Np.s....G..t.h...c.t...........s.hl..l.l.L.ND.N...-...M..S..Iu.....................s..V..G...u...l..s.........p..a..L........u..p.l.h.......s.......s...ph...........Y.p..p..h.+...p.th..c..phh..p.................tl.......h.hphhc+h..............cc.t.hKsh..hs........s..sslFE-L..GhpY..lGPlDGH.slttLlpsLcph+...............p.........h.....p.G..PhllHlhT.......................................................................................................................	0	343	706	895
+13135	PF13293	DUF4074		Domain of unknown function (DUF4074)	Aldam G	pcc	Pfam-B_2050 (release 24.0)	Family	This family is found at the C-terminal of Homeobox proteins in Metazoa.	22.30	22.30	22.60	43.30	22.00	19.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.13	0.72	-3.75	14	230	2010-09-01 16:25:41	2010-09-01 17:25:41	1	5	74	0	87	199	0	64.30	67	16.92	CHANGED	PsoGPulFGLsHL....PHssossMDY.sGAssMusupH.H........GPCDP..HP.TYTDLosHH.sSQGRIQEAPKLT	.............PsSGPulaGLsHL....sHssSushDY.sGAsshuuspH.H........GPCDP..HP.TYTDLouHH......sSQ...GRIQEAPKLT.......	0	3	10	35
+13136	PF13294	DUF4075		Domain of unknown function (DUF4075)	Aldam G	pcc	Pfam-B_2028 (release 24.0)	Family	The members of this family are putative mature parasite-infected erythrocyte surface antigen protein from Bacillus spp.	25.00	25.00	65.40	27.80	17.80	17.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.81	0.72	-3.94	12	77	2010-09-01 16:37:33	2010-09-01 17:37:33	1	2	76	0	3	33	0	77.00	93	46.08	CHANGED	KETKEIFSKKKlEstEKPETIEIQAVSPKVDELKAEEEPVVAEDGGMKEARELFMKDSNAEEKKTEAYIELKQDKEEKK	..KETKEIFSKKKVEPtEKPETIEIQAVSPKVDELKAEEEPVVAEDGGMKEARELFMKDSNsEEKKTEAYIELKQDKEEKK....	0	0	1	1
+13137	PF13295	DUF4077		Domain of unknown function (DUF4077)	Aldam G	pcc	Pfam-B_2043 (release 24.0)	Family	This is the N-terminal region of methyl-accepting chemotaxis proteins from Bacillus spp. The function is not known.	25.00	25.00	373.30	372.70	21.40	18.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.39	0.71	-4.55	4	74	2010-09-01 16:52:32	2010-09-01 17:52:32	1	1	74	0	2	55	0	175.00	95	34.95	CHANGED	MEWLKRTCFSNLEKESQKNHLLLFITICSFFLGIIAIGYYGYIFTERAIAFWhCGISVVVFGTLhTFIcSMEuhYKYIMTFMLLhMSFIMVQAFNESPAVFQMVYFTLAVSLIYLSERLllILGGVAVVlTFILCSYWPEQFFAYTAuSEAANFASLLAIVTIAMWGVTKIGSNL	MEWLK+TCFSNLEKESQKNHLLLFITICSFFLGIIAIGYYGYIFTERAIAFWlCGISVVVFGTLhTFIcSMEohYKYIMTFMLLhMSFIMVQAFNESPAVFQMVYFTLAVSLIYLSERLllILGGVAVVITFILCSYWPEQFFAYTAuSEAANFASLLAIVTIAMWGVTKIGSNL	0	0	1	1
+13138	PF13296	T6SS_Vgr		Putative type VI secretion system Rhs element Vgr	Aldam G	pcc	Pfam-B_2052 (release 24.0)	Family	This is a family of putative type VI secretion system Rhs element Vgr proteins from Proteobacteria.	22.40	22.40	22.50	24.90	22.10	21.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.20	0.72	-4.19	159	943	2010-09-02 08:37:27	2010-09-02 09:37:27	1	14	320	0	249	1034	26	106.20	38	12.58	CHANGED	S+phtG.ss..hNpLhhDDssGQ.pspLuo..sa.upSpLsLGaLsct..tsptctphRGpGFELRTDuaGAlRAupGLhloocspstAt....up.LDhspshppLppAtphhcsLups.A	............o+phtuss..hNpLhhDDssGp.+hpLuo.....sa..upSQLNLGaLsct..tsp.ptp.RGcGFELRTDuaGAlRAupGlhlSocspsp....Ap....uphL....Dhstuhp.....LpputphhcuLupsA....................................	0	24	77	152
+13139	PF13297	Telomere_Sde2_2	DUF4076; Sde2_C;	Telomere stability C-terminal	Aldam G	pcc	Pfam-B_2053 (release 24.0)	Domain	This short C-terminal domain is found in higher eukaryotes further downstream from the Sde2 family, Pfam:PF13019. It is found in all Sde2-related proteins except those from fission yeast, fly, and mosquito. Its exact function in telomere formation and maintenance has not yet been established.	21.80	21.80	21.90	23.80	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.83	0.72	-4.70	33	282	2010-09-02 08:39:50	2010-09-02 09:39:50	1	10	133	0	179	257	4	59.10	58	13.20	CHANGED	lDLssasSscELE.sLGl-RLKptLtuhGLKCGGTLpERAsRLF.lKupsh-clD++lhAK	.....lDLssFoShE.....ELt....sLGL-RLKsALhALGLKCGGTLpERApRLFSsKGpsh-plD.sLhAK.......	0	62	92	138
+13140	PF13298	LigD_N		DNA polymerase Ligase (LigD)	Mistry J	jm14	Jackhmmer:Q05W82	Family	This is the N terminal region of ATP dependant DNA ligase.	25.00	25.00	34.50	27.40	21.80	20.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.55	0.72	-3.93	134	675	2010-09-02 12:44:19	2010-09-02 13:44:19	1	11	606	8	296	710	139	106.30	50	16.03	CHANGED	QcH.....cAp+..LHYDFRLEh-GV.LtSWAVPKGP...oh-PssKRLAlp.sEDHPlsYssFEGsIPpGpYGuGs...VhlWDpGsac.sh.............pstp............th..............pcG.clphpLcGc+Lc.G.casLlR	...........QcHcApR..LHYDFRLE....hDGV...LtSWAVPKGP....ShcPs..............sKR..LAVc.....sEDHPL-YusF....EGsIPp..GpYGuGs...VhlWDpGsap.s......................s.tp...........sh..................................cpG.clphpLcGc+LpG.pasLlR......................................................	0	77	177	244
+13141	PF13299	CPSF100_C		Cleavage and polyadenylation factor 2 C-terminal	Aldam G	pcc	Pfam-B_2065 (release 24.0)	Family	This family lies at the C-terminus of many fungal and plant cleavage and polyadenylation specificity factor subunit 2 proteins. The exact function of the domain is not known, but is likely to function as a binding domain for the protein within the overall CPSF complex [1].	22.30	22.30	23.40	22.50	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.07	0.71	-4.05	58	300	2010-09-02 13:14:05	2010-09-02 14:14:05	1	16	262	0	216	303	3	149.10	29	18.79	CHANGED	V+LscsLlppL..+Wppl......cshpVutlsGpLt.............................................................................ht..t.p..pttsptptpsthchlss.....p.s..ssthss.spslalGDlRLuDL+chLts.....pG..hpAEF+.u-GsLllsst...........VuV..RKsus...............GcltlEGshs.....................ssaatV+chlY-tL	..................................................VpLpcsLlppL..papps......cshplshlsG.Lt..................................................................................t.....ht...............t.t..sppp.....shlss................h.s..ssphss..ppslal..G-lRLuDhKphLhp.....pG....h.pAEFp..tGs..L.l.s.sst...........................................VuVR+sss...............Gc.ltlEGshs..............................psaYplRchlY-th....................	0	72	116	178
+13142	PF13300	DUF4078		Domain of unknown function (DUF4078)	Wood V, Coggill P	pcc	Pfam-B_3305 (release 24.0)	Family	This family is found from fungi to humans, but its exact function is not known.	25.00	25.00	26.80	26.80	22.30	18.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.01	0.72	-3.86	34	194	2010-09-02 13:35:35	2010-09-02 14:35:35	1	4	176	0	149	186	0	87.80	36	21.56	CHANGED	ppMpplAc+RD+s.T.P..phHY-ust..ElRs+GsGFYuFS+DEcpRccQM-cLpptRpc.TpccRc.pRcct+tcRcchhc-Rhcclcpc+	.......................h.phpphtcccccshp.P......sshHY-s.t....EsRs+GsGaYuFS.p.DE-pRpcQMcpLcphRc.p.TpcpRp....cR......c....p....h......+ccR....cthlcpRhtclcp++.............................	0	49	73	117
+13143	PF13301	DUF4079		Protein of unknown function (DUF4079)	Mistry J	jm14	Jackhmmer:Q05X76	Family	This is an uncharacterised family of proteins.	25.40	25.40	26.10	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.20	0.71	-4.26	90	277	2010-09-02 14:02:26	2010-09-02 15:02:26	1	3	104	0	136	293	83	147.20	27	80.26	CHANGED	ahth...........lHPllMhll.aslsshshhLGhphRppRstps.......................................................................tphtpLl...pschpt....hHaphu.hlLshhslhslGGhsssahpssp....lFhus.HhasGluhssLhhhSsulsPth..p....up.p.thRplHlsLNslslhLFhhQulTGhcllhcl	................................................hhHPhhhhhh.hshshh.shhhGhphRphR..tt...........................................................................................h..hh.......hhph+ptHhphushhls.hhslhhlGG.hssshhpssp......la.us.HhhsGhshssLhhhusulssth..psp...p.hhRt.....hHlhLNshhhhLFhhpuhoGhpll.ch...........................................................	0	30	94	126
+13144	PF13302	Acetyltransf_3		Acetyltransferase (GNAT) domain	Bateman A	agb	Jackhmmer:Q7P3G3	Domain	This domain catalyses N-acetyltransferase reactions.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.03	0.71	-4.02	406	20736	2012-10-02 22:59:21	2010-09-02 16:53:55	1	153	4229	65	4844	27191	2993	139.30	19	68.41	CHANGED	RLhLRs.h.p....s...Dhsslh.phh.s..s.....sc.lh....ca.....hs.....shppspphl....t..............htt.http....s.hhh............aslt..........................t+s....s...........t.................p.....h.lGh.hul.................ht.............................tspsE.lG.ah.....ltps.hh........Gp.GausEAspshh......pas.....h.p....phs......h........................p...................pl.huhhts..pNhsStpl.hc+hGhp	......................................................................................................................................hhL+...h..p.....p.....D....h....t....t...h....h....phh...s.......s.................p...hh........pa...........h..h.................sh.....p.p....h..p..p...hl.....p...........hhtt..ppt..................hh......................a.s.lh..............................................................................................pcp...s...................t..............................................p..................h..lGh..lsl...........th....................................................tppps-...l.G....a.h........l.s...tp...at.....................Gp...G.h.u......s....-Ah.pth.l................cau......a..p......................phs.................l.................................................p..................+l..hh.ps..t.s........pNh....sS...t+....l..h.c.+.hGF........................................................	0	1518	2985	4028
+13145	PF13303	PTS_EIIC_2		Phosphotransferase system, EIIC	Bateman A	agb	Jackhmmer:Q7P503	Family	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.	27.00	27.00	27.00	27.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.97	0.70	-5.58	67	1977	2012-10-01 19:13:17	2010-09-02 17:03:21	1	3	895	0	191	1006	7	317.10	29	92.29	CHANGED	hcsLsGhAhullsuLlsusllpplsphlhh...........s...................hlhplsslspthhusulGsslAhthphsslhshusshAuhlGussh.h.....................tth...hhuhGs.lsshlsuhlAshlsphls....thsslclllhPllshhluuhlGhh.ltPhls.hhphlGshIsssoshpPllMullluhlhulllsoP.lSSsAlulAluLsG.....................luuGAAslGssushh..shshhoh+.NshGshlAhhlGosKlQhsNll+pPh.lhlPshlsuAlsGslushh........slp..ssssuu...GhGhsGLlGPlssh.................s.us..ss.hlhhllhhhllPhlluhlhthlh.........................+phthh+ss-.hpl	................................................+sLuulAsuhls.uLlssAlLttlhth..hhth..........p..........................hLhp.lush.h..t..uhsuhhlGsLlAhthshsPlhshllusushhus.......................................htGhGcllsshlsuhlushlhphlp....pt.sul.-....lIlhPllsss.l.ushluhl.lhPhlpshhptIGshIpshTshpPllMuIlluslhullhhoP.lSosA..lshhluLoG.....................luuuu.AslGssussh..shlhtsh.+lNs.hG......sslAlslss...shhp...hsslhpp.Pl.Ihlss.hlsuslsGllsshh........slp..ssstuu..............GhGhsGhlu.lshh.....................ss.hs..lllhllshhll.Phlsualsphlh.+hhtlhppt.h................................................................................................	0	71	123	178
+13146	PF13304	AAA_21		AAA domain	Bateman A	agb	Jackhmmer:Q7P3F0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.96	0.70	-4.45	220	6048	2012-10-05 12:31:09	2010-09-02 17:17:35	1	63	2772	13	1685	97673	27953	227.70	14	53.08	CHANGED	lsslhGsNuoGK..Ssllculthh.......................................ththh.hhhptpthptshphpht.hhtpshpaphthphpppth..................t.htthhh.ptt.t.th.th..t.ht.tt.ht..hhh.hthtt...hh.hthhh.hht.h..h........................thphhphhpphhhtpphhphhphhhptht.hththtth................................................................hhhh..ttth.h.h.t......SsG...ppph.h..slhshlhpshtt.....................sl...ll....lDEh.-ss.LHP....phh....ppll.....phh.............pptpp...............................tsQl.lhoTHs.shl.ls	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h....htth..............SsG.........ppph.h..........hlhhhlh.p...t.t.........................................................................................sl.......ll.......lDEP.Ess.LHP.....................ph.........pplh....phl................pphtp...................................ts.Q.l..llsTHu.s.l.l..............................................................................................................................................................................................................................................................................................	0	627	1112	1447
+13147	PF13305	WHG		WHG domain	Bateman A	agb	Jackhmmer:Q7P3F5	Domain	This presumed domain is around 80 amino acids in length.  It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule.  The domain is named WHG after three conserved residues near the C-terminus of the domain.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.76	0.72	-3.41	239	2407	2010-09-03 08:44:01	2010-09-03 09:44:01	1	6	1383	8	710	1956	289	84.90	20	41.89	CHANGED	tshutuYlpFAhppPshaclhF...........ttp.h...................ps...sphpp.h....h...........p..............hhtph...lpp.h..h..tt........hthst......pc...sp.phshs...hW..uhlHG.husL...hhs......sth	.............h.thuhuYlpFAhccPshachhF............ttshs.................................................tt......tphpp.s....h..............p.................................thtph...lpp.h..h..tt....................hth..ss.........................pp...st..thsht...hWuhlHGhss.L.hhss..h............................	0	225	496	610
+13148	PF13306	LRR_5		Leucine rich repeats (6 copies)	Bateman A	agb	Jackhmmer:Q7P2P7	Family	This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.90	0.71	-12.10	0.71	-4.44	205	12012	2012-10-02 21:32:02	2010-09-03 10:37:11	1	746	915	12	6389	30082	1356	113.30	19	48.31	CHANGED	spIs..stsF.hs.s.sLp.s.ls.lP..s..s..lp..p....IuptuFtsC.s.Lp..sl.p..l..Ps..s..lppIustuF.ts.C.s.L.psl.sl.....s.s..s.lppIs.pt.sFptCs..s..Lp.sls..l..s..s..s..lp...pIupt.s..F.ts.s.s.L.p.sl.s.ls.s..slp...pI..ss.ps...Fps.C..sLp	..........................................................................................................................................................................................................................................................h.p....p.....l......l..s........p.....s.........l..p...p...............I.....s.......p........t........s........F..........t.........s....s..........................s.....Lp...........p......l....p.........l......s..s........s..............l...p......p......I........s........p........t..........u.......F......t...s.....s.....................s......L.........p....p......l.......s.l.............s....s....s....l........p........p...........l..........s........p.......t..........s........F......t...t........s.s..........p................L........p..........p........l.....p.....l..........s.....p...........s..........l.p.............t..l...s.......t.................s............F.....t........t....l........t...........h.........h...................................................................................................................................................................................................................	0	5510	5860	6131
+13149	PF13307	Helicase_C_2		Helicase C-terminal domain	Bateman A	agb	Jackhmmer:Q7P4K4	Domain	This domain is the second of two tandem AAA domains found in a wide variety of helicase enzymes.	25.10	25.10	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.04	0.71	-4.30	152	5901	2012-10-05 12:31:09	2010-09-03 10:41:35	1	61	3620	5	1731	4652	739	165.30	27	22.05	CHANGED	lhplh.p.t.hs..ussllhFsSaphhpplhp.t.h...pp............p..h..................th.........t.lh..h..p................s...pt..s..tppll.................ppap....p......s....................................psu.l.Lhust....ph...EGlDhs...sct..hpsVll..stlPa..........ssspsshhpt+tpahc.p.....pt.....................................................tss........hp..p.hhhspAhtplpQuhGRlIRpps...DhGsllllDpRht...p.....pp.htpt.l.....phltst	..............................................................................................h...hhphtt..sthllLFsShphhpplhc.h.h...pp..............................................p.h..........................ph..............ll.hQ.......................................s...pt..sptpll.................pp.Fp..p........s.........................................................................................psu..lL..l.uss...u.....FhEG....lDlt...G....c...t......lpt....V....lIs+lP.F...........................sssssP.....lhps+h.chhc.p.....ps.....................................................................................................................tss...........Fp.p.h.tlsp.Ahh.p.lpQ..ulGRLIRs.ps...D...pG.s........l.l....lh.............Dp............Rlh...p........pp...Y.s...pth..psls..h.............................................................	0	576	1031	1435
+13150	PF13308	YARHG		YARHG domain	Bateman A	agb	Jackhmmer:Q7P768	Domain	This presumed extracellular domain is about 70 amino acids in length. It is named YARHG after a conserved motif in the sequence. This domain is associated with peptidases and bacterial kinase proteins. Its molecular function is unknown.	21.30	21.30	26.20	26.10	19.10	17.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.68	0.72	-4.44	105	463	2010-09-03 15:16:03	2010-09-03 16:16:03	1	33	361	0	77	396	21	81.60	28	22.53	CHANGED	sphhh.sp...sssphlspsplpshs..sp-LplhRNpIYAR+GhpFps.tplpsYFs.spsWYpssh..........................pshLsshEppsl...p.hlpphEp	...................................t....h.t....s.phhs...pplpths....ppcLclhRNEIYAR+GahFps.t-hp.pYFs...pps..WYpssh.........................sshlochEppNlc.hlcphp.......................	0	38	61	67
+13151	PF13309	HTH_22		HTH domain	Bateman A	agb	Jackhmmer:Q7P8J8	Domain	This domain is a helix-turn-helix domain that is likely to act as a DNA-binding domain.	29.60	29.60	29.70	33.10	29.30	29.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.77	0.72	-4.21	187	1886	2012-10-04 14:01:12	2010-09-03 16:51:08	1	5	1465	0	294	997	44	63.90	37	28.64	CHANGED	-hlpphl.ppslp.ph.stss....shhsppc+hpllptLpcpGlFtlKsusstVAptLslS+hTlYpYLc	.............................-llsphl.cpslc.pl..sssh....sl.spscp+pI....VhpLa-+GlFplKcAlspVAcpLsIS+tTVYhYl+...	0	75	143	221
+13152	PF13310	Virulence_RhuM		Virulence protein RhuM family	PIRSF, Bateman A	agb	Jackhmmer:Q7P417	Family	There are currently no experimental data for members of this group or their homologues. However, these proteins are implicated in virulence/pathogenicity because RhuM is encoded in the SPI-3 pathogenicity island in Salmonella typhimurium [1-2].	27.00	27.00	27.10	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.72	0.70	-5.38	118	1101	2010-09-03 16:18:37	2010-09-03 17:18:37	1	10	730	0	253	1002	83	187.10	38	65.40	CHANGED	cusl+cathstp-Gp+.....tcplpaYNLDsIIuVGYRVpShRuTQFRpWATphL+EYllKGFlhDDERLKsss......hstDYF-ELLERIR-IRuSERRFYQKlpDIYA.sSlDYDssuptTppFFupVQNKLHaAlpGpTAAElIhpRADupKspMGLToW+su.....+.lpKsDVslAKNYLsccElcpLNRlVohaLDaAEhpAcR+hsMsMpDWtp+LDpFLphs-pclLpsuG+lSpctAcppAcpEa-cachpp......php.sDa-	............................ushpphhhstt-Gpp........hp...hpaYNLDsIIuVGYRVpS.+u..T.pFRpW.A.TphL+-YllKGashsc..c.RL+pss.......paacchLtclR..p...IR.SEt.hh.a..pl.h-lat.hu.D....Yp...p...s..Fat.hQ.Nh..hhauhtt.....Tus-ll..pss.....huh.thttt.........-h.hu.KNYLt..ph..ht.....hht.hp..h.tt...h.ht.h...hp.hh...t..hL.t...Gthp...h...s................................................................................................	0	95	189	225
+13153	PF13311	DUF4080		Protein of unknown function (DUF4080)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering  human gut metagenomic sequences [1].	22.90	22.90	23.10	23.40	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.24	0.71	-4.27	54	385	2010-09-03 18:13:29	2010-09-03 19:13:29	1	5	375	0	101	364	15	171.30	22	30.98	CHANGED	uccaGhlYpstsPYEVLpTcaLSYc-ll+LKplE-hlEhYYNSupFspolcalhppa..soPFchYppLucaa-ccGahphs+uptphYclLh-Fh.........p......-pthc..t..hh+-lLpaDahhppp..t+shPpFh.tppppt.cpp.hpth.hpctpthph.....ht......pphh+hsHlEhFp........hs.................ppp.hlLF	........................ccaGhhYpshPPYElLpochlSap-lhpLKplEchl-tYYNSspFppolchl.h.p.ph.....tssFcFapphu.p.a.apppshhphshuhpchaclLhcFh..........................................p........pph.t......p.phhppllphDahhh.pp..hc.h..Ptah.tt.......p.....p.t...tpt...hhth....hpp.......................t......................................................................................................	0	48	88	94
+13154	PF13312	DUF4081		Domain of unknown function (DUF4081)	Aldam G	pcc	Pfam-B_2088 (release 24.0)	Family	This domain is often found N-terminal to the GNAT acetyltransferase domain, Pfam:PF00583 and FR47, Pfam:PF08445.	21.70	21.70	23.30	21.80	19.20	21.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.31	0.72	-4.11	49	307	2010-09-06 12:54:03	2010-09-06 13:54:03	1	4	306	0	85	197	16	108.80	45	38.43	CHANGED	Gu-lWGhhtt....GtLsulCauGANLlPltu........sssu...lcAFA-+ApcpuRRCSSlVGPA-sVhsLWcpLcs....sWGsA.REVRssQPLhshsssP...tlssDPt........VR.lR.cEl-hll	.............uplaGhh.t....GtLpuLCasGAN...LlPltu......................................sssslcAFA-+Atct.RRsSSlVGsAcsVLsLWcRLp.....sWGsA....REVRssQPLhAhss.pP....plssDst..........VRplp.c-h-sY....................................	0	28	65	80
+13155	PF13313	DUF4082		Domain of unknown function (DUF4082)	Mistry J, Aldam G	pcc	Pfam-B_2054 (release 24.0)	Family	This family appears to be a parallel beta-helix repeated region that sits between successive Cadherin domains, Pfam:PF00028.	21.50	7.00	21.50	7.00	20.80	6.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.85	0.71	-4.76	61	169	2010-09-06 13:08:15	2010-09-06 14:08:15	1	38	53	0	108	198	22	144.50	38	27.55	CHANGED	lasssssPssss.ssD..ssulELGs+FpusssGplTGlRFYKu...suNTGTHoGoLWousGslLAosTFTsE.ouS..GWQpssFuoPVslsAGTTYVsSYaussGpYusossaFsss.hss.GsLpA.....husu.....N..GVYsYuuushFPs..sSapuoNYWV	...................................lasssssPssss.ssD..ssslELGh+FpusssGploGlRFYKu...uss..TGoH.sGsLWou...s...GshLAo.sTFo.sE....ouS...G.WQpssFusPVslsAsoTY.Vs.SYpsssGtY.ussss.aFss........s.hss..usLpu.usu............NGVYtYuus....hFPs..soa.psoNYWV.........................................	0	31	55	84
+13156	PF13314	DUF4083		Domain of unknown function (DUF4083)	Mistry J, Aldam G	pcc	Pfam-B_2061 (release 24.0)	Family	This is a family of very short, approximately 60 residue, proteins from Firmicutes, that are all putatively annotated as being MutT/Nudix. However, the characteristic Nudix motif of GX(5)EX(7)REUXEE is absent.	21.90	21.90	22.10	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.84	0.72	-4.14	10	78	2010-09-06 13:30:24	2010-09-06 14:30:24	1	2	65	0	3	58	1	57.20	60	92.23	CHANGED	M......ltshIYhh..hhllllhussFshhIRhllpsSstKKQc..slEQKLD+IIpL...LEKp	.........l.shIYTCLVIGLIVLFFlSFT..L..F.IRRVLQSSsA.KKppshsMNQKLDRIIEL...LEKD.........	0	0	1	1
+13157	PF13315	DUF4085		Protein of unknown function (DUF4085)	Aldam G, Mistry J	gba	Pfam-B_2570 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 101 and 269 amino acids in length.	24.10	24.10	27.30	37.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.20	0.70	-4.96	7	89	2010-09-06 14:00:34	2010-09-06 15:00:34	1	2	79	0	6	74	1	167.80	52	85.01	CHANGED	KYFs+-aYccMQlpsalpa.Eo.cEWEph.........-ahppLKEEhc.h.p.-LL+aLPcolaPhlpsso.lsothssscLKchhhEWsp-aEtchpplppuYh-paspItc+LPusVtQLa.phSLHDuhIpslc.+scsoLpIhLDsSGsFSpFsKLplTFhslT+sphsENF.-GuWWLYaEItLT-cG.FEhtVLFDsPhc..EloIhA	......................................KYFs+-WYKcMQl.tFlpF..EolcEWpEh...........hpSL+--hE-+.K.DLLKFLPcSlashIps.T...lsS-.YPStcLKKhhhcWopDYEKRhspLppuYh-.as..SIcc+LspNVhQLa.chSLHDu.lpslc+cS....cDol.IsLDCSGoFsEFDKLplTFhGV.oKCShsENF.EuAWWLhHEIsLs--G.FELGVL..FDsPFc..EVhIsA..................	0	3	6	6
+13158	PF13316	DUF4087		Protein of unknown function (DUF4087)	Aldam G, Mistry J	gba	Pfam-B_3066 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 140 and 280 amino acids in length. There is a conserved RCGW sequence motif.	25.00	25.00	34.60	34.40	19.20	17.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.35	0.72	-3.83	11	83	2010-09-06 14:02:00	2010-09-06 15:02:00	1	1	79	0	19	63	0	99.90	52	52.17	CHANGED	suspsEpRCGWh-NPoPANhoLpDc-GpWpIusQG.Ga..pscG...hPs..hssspaVpT.susaGYuCAChslssDscptplspIpps+phPLupCRpDhuL..pc.	...t..spAEpRCGWhpNPTPu....NhhLsDR-GpWpIGTpG.Gh...pscG......Ps..hu.s..sQaVcT....N...GsaG..Y.uCAClTssT.D.pppRlsplhKApthPLStCRpDKpLKEP..................	0	3	10	14
+13159	PF13317	DUF4088		Protein of unknown function (DUF4088)	Aldam G, Mistry J	gba	Pfam-B_3345 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 258 and 300 amino acids in length.	24.10	23.70	214.20	214.10	24.00	22.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.52	0.70	-5.01	4	61	2010-09-06 14:03:01	2010-09-06 15:03:01	1	1	61	0	20	51	0	229.00	80	80.43	CHANGED	RLR+-F-sFlpVSTGLDtpFlPPpFsDFLRARLLQpDGPLTERAV.RLLuuGEYGWA++VFDKQLPNALAuLMRDApRFGFGLAVQs-WoPpQRhcHAR-WAAQlLuEsGADAAaT-ALAuQluASApDlRsLEERM+TPAWRLAESLRQRAYDlMYALQTEssEshGRu+VGELRuhLsLALpYGShQh-EAsRVLEQlcRs+PcLFpEAPDDVFARLAAWLRRhFsps	S.LRKDYDAFVRVSLKLDPQFsTPSFEDFLRAKLLDsMVPLTEHAVQRhLQGGQYAWAKRTLDKEFPDVVuILhRQAG-FGFGFASRSEWTPDELAKACRDWAAAlVupAQGDAuLVDPLAAQIKSAVpDIQTLEEpMQTPAWRLAESLRQRVYEAKLACEMSVGSsA.REKLGELRGLLRLGlAHGSFQKQEAQQIMEYLRLLKPEIFlEEPYDlFsRlAAWLRShFhsu..	1	1	4	11
+13160	PF13318	DUF4089		Protein of unknown function (DUF4089)	Aldam G, Mistry J	gba	Pfam-B_3700 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	21.60	21.60	22.40	22.30	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.21	0.72	-3.66	33	163	2010-09-06 14:03:51	2010-09-06 15:03:51	1	2	162	0	52	131	2	49.60	39	77.12	CHANGED	YlpphutLLuLslcsphRssVlsphp+IsshAp.lhsFPL.s-chEsAsVF	...YlpphtplLuLsLD-spRsslhtpFp+IAshAp.lhsaPL.s-chEhAuVa.......	0	5	23	35
+13161	PF13319	DUF4090		Protein of unknown function (DUF4090)	Aldam G, Mistry J	gba	Pfam-B_3702 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	22.70	22.70	24.60	31.70	20.80	16.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.88	0.72	-4.04	15	61	2010-09-06 14:04:41	2010-09-06 15:04:41	1	1	60	0	23	58	101	82.80	63	88.35	CHANGED	GsDAVDpAIusGlDLDGoPIPssMLsLYpcVMsLEupRpRSGVpKSMRNRIVRoGAKHhsp-sLNQhLl-AGW-GLK-KEIuFF	....GsDAlDtAIssGlDLDGSPIPsshL-LYpcVMsLEupRQRSGVppoMRsRIVRhGAKHhsQ-pLNQhLlcAGassLK-KEIAFF.	0	2	13	21
+13162	PF13320	DUF4091		Domain of unknown function (DUF4091)	Aldam G, Mistry J	gba	Pfam-B_3704 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	22.50	22.50	23.10	22.60	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.46	0.72	-4.07	63	346	2010-09-06 14:05:22	2010-09-06 15:05:22	1	22	286	0	79	284	31	71.00	34	11.20	CHANGED	hshsGhL+Wuas.ha..sp.......sPap..ss.phth..a.ssGDsallYPGps.........ttshsSlRhchhpcGlpDhchlchLcp	...........................t.phsGhL+WuhN.hW...sc........................-Pht.........Dsphch.......a..suGDshllY.Pusc...........tt.hs.SlRhchLtpGhpDhchl+hlc.p....	0	29	54	74
+13163	PF13321	DUF4084		Domain of unknown function (DUF4084)	Mistry J, Aldam G	pcc	Pfam-B_2026 (release 24.0)	Family	This family of Firmicute proteins is frequently associated with the EAL, GGDEF and PAS families, Pfam:PF00563, Pfam:PF00990, and Pfam:PF00989. The exact function is not known.	22.00	22.00	23.40	23.20	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.97	0.70	-5.18	8	77	2010-09-06 15:42:46	2010-09-06 16:42:46	1	5	76	0	2	60	0	194.50	89	25.51	CHANGED	MINQKKYVHFVhhYIIIFSLWIFLIPK-LNIKEIGILFLFCFAsLFSCYCLYKAIKKMKRGDKLFWVLlLCTCLCGLTMEITLFLHSLSIYDQVIFSYKALPFFIlQYILLFSGFAIKFIKHYSIRGLAQFSFDSIF.IlIMNIYFTLTFILDlSSFRMLTpDTWVLIGYFIAQSLVIYAVISLYRREQYSSSRISLIIGFTIILVYGYIHLFQLNAGhKTSSEVSYLIHTASILLIGLSSILYILDKPMQHETKTKYYRFDYVRFILPYFSIIITFSFIIhQPWDDKFMLIGLVLSLILLFLRQ	..............................................................................................................................................................................................MLTpDTWlL..IGYFIAQSLVIYAVISLYRREpYS..SSRIuLIIGFTIILVYG.YIHLFQLNtGhKsSuElSYLIHTASILLIGLSSILYILDKPhQ...HETKTKYYRFDYVRFILPYFSIIITFSFIIhQPWDD.KFMLIGLVLSLILLFLRQ............	0	0	1	1
+13164	PF13322	DUF4092		Domain of unknown function (DUF4092)	Mistry J, Aldam G	pcc	Pfam-B_2068 (release 24.0)	Family	This family is found in Proteobacteria. The function is not known.	22.20	22.20	23.40	69.80	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.00	0.71	-4.52	16	289	2010-09-06 16:06:56	2010-09-06 17:06:56	1	3	274	0	9	193	2	170.60	77	11.51	CHANGED	lAtpIDppLptp.sthspth.......hsshsssuuplpsslp+Lhsh..t.....a+sVspFHVFHDsosFYGuoGsARupsslNIoNpAFPVlMsRNDpNYWlsFGpppAWD+....suhAYIT...........................-APS........hlpP-+Vop-TATFNLPFlSlGclGcGKVMVMGNu+YNSlLsCPssYSaNGul	..............................................................Q.AKEIDTAICAK.TsGCNEARWFS....LTTRNVNDGQIQGVINKLWGVDss.....YKSVoKFHVFHDSTNFYGSTGNARGQAVVNISNAAFPILMARNDKNYWLAFGEKRAWDK....NELAYIT...........................EAPS........lVcP..ENVTRDTATFNLPFISLGQVG-GKLMVIGNPHYNSILRCPNGYSWNGGV.	0	2	4	7
+13165	PF13323	HPIH		N-terminal domain with HPIH motif	Mistry J, Aldam G	pcc	Pfam-B_2165 (release 24.0)	Family	This family is found in fungi on proteins carrying the PAS, Pfam:PF00989, domain. There is a well-conserved characteristic HPIH motif, but the function is not known.	20.30	20.30	22.40	30.70	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.02	0.71	-4.52	40	137	2010-09-07 08:27:00	2010-09-07 09:27:00	1	7	118	0	92	146	0	149.80	28	13.89	CHANGED	p+plTssLptlu+puCpHPIHTIllsALLASooYlull-sslhc...sspshstps..phsshltGu+sLhhGpsouW....cWphh-stsstsps..........spHhALhTLsFPco...ssssshPthcslshssNhStphLsposshhoshsp......-sulsaslPasps	..............+plotslttlu+huspHPIHTIVlsALLASsoYlull-tslh-....ssss..ssps.........chssh.ltGupslhhupsouW.....pWpshssppststs..........spHhALhTlsFscs...ssssssPthpsl.hssshothhLspo.sshhoshsp.......-sulsaplsasp....................................	1	13	44	76
+13166	PF13324	GCIP		Grap2 and cyclin-D-interacting	Mistry J, Aldam G	pcc	Pfam-B_2169 (release 24.0)	Family	GCIP, or Grap2 and cyclin-D-interacting protein, is found in eukaryotes, and in the protein Swiss:O95273, residues 149-190 constitute a helix-loop-helix domain, residues 190-240 an acidic region, and 240-261 a leucine zipper domain. GCIP interacts with full-length Grap2 protein and with the COOH-terminal unique and SH3 domains (designated QC domain) of Grap2. It is potentially involved in the regulation of cell differentiation and proliferation through Grap2 and cyclin D-mediated signalling pathways [1]. In mice, it is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumours. In vitro it acts as an inhibitory HLH protein, for example, blocking transcription of the HNF-4 promoter. In its function as a cyclin D1-binding protein it is able to reduce CDK4-mediated phosphorylation of the retinoblastoma protein and to inhibit E2F-mediated transcriptional activity [2]. GCIP has also been shown to have interact physically with Rad (Ras associated with diabetes), Rad being important in regulating cellular senescence [3].	21.40	21.40	21.40	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.82	0.70	-5.18	12	246	2010-09-07 13:57:06	2010-09-07 14:57:06	1	4	169	1	171	242	1	213.70	19	65.93	CHANGED	Wpclschu-pVS+pAThluhlW.pG.hPcs-shpcsh-saasuLpGhlLssHGpslGAGsTLppsl+sulKplVDuohpLhptsVS..h.tS.ppshcsslsplsGsVWEACsshc+lPpoNhsAIGpuhoplushlKDlLcEMcchh...............hhspupsstsssp.s-ss..s...spD..hS.E-hcVsp.shullppohsslKclIpsIsshh.......t-spshVspLEcLLclspclusplD-LGsSlY.PP.-hspl+tslp+ltuslcchhp.l	............................................................................................................................................................................................................................................................................................tt.p...t.......t..........sutlWt...sCpth....p.hs....p.p.sh.h.u.h.h.h.h.hp.p....hshlcDsh.cEhcph................................................................tpptp.....s.......t-p..p......t....t.s.......pD.................hp-.-..st.tlhp..sh..sllphsh...s...hlcpl....h........t....h.h.t.t..h......................t..p.......pps....s....p.L-cllshs.pcIssp..lD-lstolY...PPhs......lc.p..ttl.....................................................................................	0	50	78	117
+13167	PF13325	MCRS_N		N-terminal region of micro-spherule protein	Mistry J, Aldam G	pcc	Pfam-B_2099 (release 24.0)	Family	This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1) [2]. In conjunction with DIPA the full-length protein acts as a transcription repressor [1]. The exact function of the region is not known.	22.60	22.60	22.70	22.70	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.22	0.71	-4.80	17	183	2010-09-07 13:59:08	2010-09-07 14:59:08	1	4	121	0	119	177	0	156.60	41	30.57	CHANGED	RWKPhDDLALItulpQTNDLchVHpG.lKFSC+FTLpElppRWauLLY-PslS+lAssAh+sLHPEsltulQs+ALaSptEEpLLuolpSsp.....pPsL-pFQ-LLccpssVFatuRTAKoLpsHWhLhKQYhLLPDQsVpPhtpsp.pslSFS....DAE-plsDs-Lp-scDE....uLEpELtlsDR+pKR-IRhLENELsRWsVLVD	....................+WpPtDDLhLlsuV.psssLptlahG...V+.FSp+FTlpElpcRWauLLYDPsl.....SphAstuMpp.............LcP-h..hs.u.lp..p+slaS.tEEplLtp.lts..sp.....................tsph.ppFpcLLp..ppspsFa.uRTspsL...sHW...hh+pah..LL...DQshtsh...tt...........shs....c.pt.h.p..................................................................................................................	0	38	58	94
+13168	PF13326	PSII_Pbs27		Photosystem II Pbs27	Mistry J	jm14	Jackhmmer:Q05RN1	Family	This family of proteins contains Pbs27, a highly conserved component of photosystem II.  Pbs27 is comprised of four helices arranged in a right handed up-down-up-down fold, with a less ordered region located at the N-terminus [1].	25.00	25.00	26.40	34.10	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.67	0.71	-4.21	61	146	2010-09-07 15:30:42	2010-09-07 16:30:42	1	2	100	3	77	153	105	141.20	29	87.46	CHANGED	hhpcll.......hulsL...sh......sl...h............lsus.............................t.ssss.slo...Gs.....YhcDThsVlpsLpssl..shs.....pDsss+pcstspA+chIs-alu+YRtpsplsu...................h..sSFsshp.oALNuLAGHYssaus+.PLPccl.+pRltpEhppAEpul	....................................................hhhhh.............hshhh....h.......h...h......h.ss....................................h.sssp.sho....Gc...........Yhp-ThsVlpsL+psl.shs.....p-ssshtcstspA+ptIs-alu+YRppsslsu.....................h..pSFsshp.oALNuLAGHYssaGs.p.PlPccl+pRlhpEhspAEtul.................................	0	22	53	70
+13169	PF13327	T3SS_LEE_assoc		Type III secretion system subunit	Mistry J, Aldam G	pcc	Pfam-B_2123 (release 24.0)	Family	This is a family of bacterial putative type III secretion apparatus proteins associated with the locus of enterocyte effacement (LEE).	25.00	25.00	47.40	47.00	22.80	22.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.80	0.71	-4.67	16	253	2010-09-08 13:46:21	2010-09-08 14:46:21	1	2	242	0	12	81	0	129.80	46	81.76	CHANGED	hhpLHpLsWpPupaAHPhWLssl.Glpsps.apYGcustLDssLsphLtphRsa.ppsLPssLsspQpp.lthttRlsshslALGLlpLpCsDYLhLppYRpsLtshLu-ssIpQLhGh.hhpGpp......sspL..sPppLsshAhplGpulhpphtsssslh+AlulhLPP	.............haphh..Ph.hhhs.WLstl.Ghp..s.hthtcp.thcp.LsthL.p.ht...phl.hs..sppth.ht.h.+l.hhshu.ulhtlpCsDYhhL.cYRQhLlphhu-s-IhQLhGa..hGtps.........tt.L..sPphhppsALplGsulL......sp.tpDsslhpAlhlLLPP..........	0	2	6	9
+13170	PF13328	HD_4		HD domain	Mistry J	jm14	Jackhmmer:Q05RX6	Family	HD domains are metal dependent phosphohydrolases.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.08	0.71	-4.50	118	7076	2012-10-01 20:28:14	2010-09-09 10:34:10	1	37	4412	2	1646	5095	2697	149.10	37	23.59	CHANGED	AhthApphat................tppttsGpshlsHslslAt..ll...tph....t...hD...ps.......sh..hAulLacss..........c..............-..........h.............pp............lp..cp....F...GspVApLVpuss.chtplpph..................ttp.......ptph-...slR+.hl...luh.....pD...h....RVl..Ll+LA-RlpslRth.......................tlApEshslausL.AsRLGlh	....................................................Ah.hAtptHp................sQhRp..S..G..-......P.Yl.h.HPlt.VAt.....IL....uch......p........hD........ts.................ol.hAA.LLH..D.ll...............E.................D.......................T......sss.....-c..........................lc..pp......F......Gpp......V.A...p.LV-GVo.Klsclpht..............................................spp...............ptpuE.....Nh.RK.MllAM.s.cD.l......RVl....llKLADRlHN.....M..RTL.....pth.....-...........KptclAcETh..-IYAPL.ApRLGl.t...........................................................................................................................	0	513	1040	1361
+13171	PF13329	ATG2_CAD		Autophagy-related protein 2 CAD motif	Mistry J, Aldam G	pcc	Pfam-B_2170 (release 24.0)	Family	The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex. Atg2 binds Atg9. The precise function of this region, with its characteristic highly conserved CAD sequence motif, is not known.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.02	0.71	-4.65	37	161	2010-09-13 10:50:17	2010-09-13 11:50:17	1	7	152	0	115	168	1	145.80	25	7.67	CHANGED	slslcDCslGLNPhphsuKsllllspuphsssh.tttpsphshpl+cuolhlIDDlps.t..........p..tp.ss.tssphps....hp.shGalslupIoosplslphtp.sppttpp............lDlcl+sDhlhLEsCADSTQTLIsllssLpPPs..Ps..ppKYR.T	...............................................................p.lthhDCslsLpPh.thsu+hllslsssphsssh..tp....sp...p.hphplccuslhlIDDsps......................tt.tstph.p.....hh.spGYVslsplushpls...lph.hpss..ppsppp............l-lclpsDllhLcTCADSspTLlsLlssLt.P...ss..t.Kap..................	1	27	56	95
+13172	PF13330	Mucin2_WxxW		Mucin-2 protein WxxW repeating region	Mistry J, Aldam G	pcc	Pfam-B_2205 (release 24.0)	Family	This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.	22.40	1.00	22.40	1.80	18.40	-999999.99	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.88	0.72	-3.55	91	678	2010-09-13 12:29:30	2010-09-13 13:29:30	1	101	53	0	385	687	1	85.80	34	12.24	CHANGED	tWTsWhstD.pP....s.ssG.DhEThss.lp..tt............hC....ptPs...s.IpCR..sh.........s.tpsGpt.lpCsh.ssGhh...ChNs.-Q..s.......ChDYEVRh.C.......C	.........................tWTpWhshchP........u.ssG..DhEohps.l+....tstp..........lC.........ppPhslcCRsps................sthsh.pp.hG.ps....lp..C.sh..shGLh...ChNc-Q.sth.......ChsYclRhhC..................................................	0	168	181	262
+13173	PF13331	DUF4093		Domain of unknown function (DUF4093)	Coggill P	pcc	Jackhmmer:Q7P4Q3	Family	This domain lies at the C-terminus of primase proteins carrying the TOPRIM, Pfam:PF01751, domain. The exact function of the domain is not known.	25.00	25.00	28.60	30.40	22.30	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.77	0.72	-3.78	141	1316	2010-09-13 13:16:25	2010-09-13 14:16:25	1	5	1303	0	153	724	4	86.40	42	46.33	CHANGED	slGVEpAos-sIpcALpclts...ppp..p.ppp.......................lohpDLhphGLhusssu+............pRRctLGchLsI.GYsNuKQLl+RLshatIocc-hppAlp	.....slGVEHAS.EsIccA.Ltplpp.....hc.p..t.pp........................IopsDLlchGLluGssu+............cRREhLGcpL+I.GYoNGKQLlKRLphFGlTps-lccAh......	0	59	102	128
+13174	PF13332	Fil_haemagg_2		Haemagluttinin repeat	Coggill P	pcc	Jackhmmer:Q7P6T3	Family	\N	22.00	15.60	22.20	15.60	21.90	15.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.39	0.71	-4.48	155	4185	2012-10-02 14:50:22	2010-09-13 16:16:57	1	347	516	0	992	4738	66	124.60	16	23.22	CHANGED	luhs..p..op....opsp...ppss.ss...su..Ssls.uG...ss...lslpAs.......p................uslsltGopl....pus...............s..ltLp.Asp.slsl.puup...ssppppsp.s.............p.SpususGluluhus.ss.......h.sh.su..ssutucu..p..ts..u..sus..shss.opl...s.uu.ss.ls.lpS....Gp..DoslpGAplsu..pplsssl.Gs.....s..LslpShQ..Do.......s..p..h....s..sp......s....tu..u	...............................................h...........tptp...tp.p.p..pt......u..oplp.us......ss.lslpAs......p..........................slsl.p.G..opl.....pu.s..............................................p.s.ls.....l.....t.A.....s.....p..sl.sl..tu.u..p....s..p...p..p..p....p....p...p..p.............................................p....p...t.............t......s.h.........t.............................................................................................................................................................................................................................................................tt..........................................................................	0	79	422	731
+13175	PF13333	rve_2		Integrase core domain	Coggill P	pcc	Jackhmmer:Q7P766	Family	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.76	0.72	-3.89	38	2406	2012-10-03 01:22:09	2010-09-13 16:55:03	1	11	1136	0	213	9884	987	54.10	42	39.33	CHANGED	EuFFGhLKsEhhasp..papohcchcpslp-YIpa.Y....NpcR....L....K....G....LoPlpYRspsL	...................EsFFGhLK.sEh....a....Y..ut......pa...p..o..h..c..p..L.c.p.s.I..h-.Y.I.c.Y.Y.....NpcR.................l....K...........G....LSP.lp.Y.Rpp..................................	0	41	116	163
+13176	PF13334	DUF4094		Domain of unknown function (DUF4094)	Mistry J, Aldam G	pcc	Pfam-B_2504 (release 24.0)	Family	This domain is found in plant proteins that often carry a galactosyltransferase domain, Pfam:PF01762, at their C-terminus.	24.50	23.80	24.50	24.30	24.40	23.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.32	0.72	-3.60	46	197	2010-09-13 16:05:43	2010-09-13 17:05:43	1	6	33	0	130	187	0	86.40	30	23.32	CHANGED	St+h.sllLChsSFhhGllhosRh...W...s....t..............tppppchplhpp-ssspp.......tpppclhtcVscT+psIp...sLDKoIosLEMELAuARup	.......t+h.shlLshhSFhhGhh.ho.sRh...W....s.t.............................pptppchpll....pp.s.sspcp................pppchht.pVscTp.csIt...sLDKslusLEMELAuA+u..........................	0	16	77	104
+13177	PF13335	Mg_chelatase_2		Magnesium chelatase, subunit ChlI	Coggill P	pcc	Jackhmmer:Q7P325	Family	This is a family of putative bacterial magnesium chelatase subunit ChlI proteins. The domain lacks the P-loop region present at the N-terminal of Mg_chelatase, Pfam:PF01078.	22.20	22.20	22.20	22.50	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.03	0.72	-3.59	197	3113	2012-10-05 12:31:09	2010-09-14 12:06:40	1	12	3054	0	770	2544	357	95.70	39	19.76	CHANGED	puEoSssl+.pRVhtARptQhpRhs.................ph.......Nupls......uptlc.ch.stLsppstphLcpulp+hsLShRuhcRlL+VARTlADLpuppplsppHluEALsYR	...........................t.uEoSssl+.pRVhtA.RchQhpRht.......................ch..............................NApls......upplc.p.a..C..t.LsspstphLcp...A...hp..+hsLSsRuacRlLKVARTIADLcs.s...-.......p....IsppHlsEAluYR........	0	270	528	664
+13178	PF13336	AcetylCoA_hyd_C		Acetyl-CoA hydrolase/transferase C-terminal domain	Coggill P	pcc	Jackhmmer:Q7P7G0	Domain	This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.67	0.71	-4.55	251	2410	2012-10-04 00:26:15	2010-09-14 13:36:31	1	17	1795	21	696	2411	257	149.60	42	31.00	CHANGED	GopcLY-al.....-.....p.....NPplth.tsssasN.........s...PtlIu..ppsphluINoulclDLhGQVsu-sl.G.......s+..hhSGsGGQhDFl+GAthS..pG..G+oIlslsSTs..p........s...G....p....l.S+IVPhLs.GusVossRsclcalVTEaGlA.sL+G+ohpcRAcsLIs.IAHPcFR-pLhcpA	.................................................pchYc.h.....-p.....ps.cl.hh.RPt-hoN.........s..Pcl.Ip..+.hsl..lulNsulEhDlaGplNSspl..G.......s+hhsG.lGGpsDF.sRsAhh.........SIhsssSsA..c..............s...G....p.......I.SsIVPh....ls........pVspocpclcllVTE.Gl.A..D.LRGhosppRActlIs..hAHPcaRstLpch.h...............................................	0	268	472	621
+13179	PF13337	Lon_2		Putative ATP-dependent Lon protease	Mistry J	jm14	Jackhmmer:B8D5Z7	Family	This is a family of proteins that are annotated as ATP-dependent Lon proteases.	19.90	19.90	20.10	20.80	19.30	19.70	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.54	0.70	-6.13	53	313	2010-09-14 13:27:09	2010-09-14 14:27:09	1	3	292	0	83	269	74	438.10	48	68.76	CHANGED	sphF.sGhV.....VRKDLs+plKtuss.VPsYVLEaLLGpYCAosD-ppIcpGl.ppV+chLscpYV+scEuchl+S+l+EcGp.a+lID+lsV+Lsp+cDtY.AphsNLGl..c..clhIssphV+c.a-+LLsG.GlWsllslpYp...................hs-.................spcs.......sP..FhlpsL+PIQhsshD.hcphhpuRppFTp-EWlDlLlRSlGhEPss..hsc............RtKhhhLsRhlPhVEpNYNllELGPRGTGKSHlapElSPa.uhLlSGGpsTVApLFhN.ust...plGLVGhWDsVAFDEVuGl.pFc-.+Dsl.sIMKsYMASGSFuRGc..-..plsAsAShVFlGNls..psV-thl+su..H.LFsPhPpthp.Do...AFhDRlHsYlPGWElPKh..+s.-haTspaGhlsDY.LuEhh+phRc..ps..assslpcaFcl.GssLspRDppAV+KTlSGLlKLLaPs....GphocE-.lcchLchAlEsRRRVKEQL.K+luuhEFhcspFSY	.............................................ptF.sGpVVRK.D.L..s+..p..lK.tGA.N.VPsYVLEYLLGhYCuo-D-phIppGlpsVKcILu-sYVRP-EAptl+Sp.l.R.EcGp.a+lIDKloV+LspKcDhY......AphsNLGl..p....ss.lssphV+c...-.+LLsG..GIWsllslpY.....................hc.c..........................................spps.......sP.F.lpsL+P.IQhs.s.hD.h-c.lhpu.RppFop-EW..lDlLlRSlGhE.Psp..h..sp............RsKhhlLsRhlPh.....V.....E...sN....YNlsELGPRGTGKSHl.Y+EhSPp.ulLlSGGQsTVAsLF....YNhus+...plGLVGhWDsVAFDEVAGI..p....FK.D....KDuV...pIMKDYMASGSFuRG+....-.....plpupASMVFVGN.IN..po......V-.s...llKTS...............+LhsPhPpthh..D.o...AFhDRhHsYlPGWElPKh..+P..EaFTspYGhloDY.LAEhhRc.hR+....p.s....a..uDsl-caFcL...Gss......LspRDshAV++TVSGLlKL..LaPs........GpaoKE-.lc.phLphAlEhRRRVKEQL.K+lGGhEFa-lpFSY.........................................	0	38	63	75
+13180	PF13338	DUF4095		Domain of unknown function (DUF4095)	Coggill P	pcc	Jackhmmer:C2D0I5	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.64	0.71	-3.98	231	2088	2012-10-04 14:01:12	2010-09-14 16:14:53	1	8	1014	0	614	1837	131	118.00	17	48.01	CHANGED	Gl.......s.....htlp..chh.cpGplp+lp+GlYh...........h.......sst..................hcp.........hh........hh.stt......h..............s.pu.....l.lu.htoALhhau..l..s.s..p.hP.t.thpls...sspstp...t.php.......tlphhth.p.tphhp..h.Ghpphph....stsltlhshERTlsDhh	................................................tlpchh..ppG.t.l.+l...t.+..G...lYh.............h.ssh...................................hcp.........hh...........hh.ttt..h..............................s.pu......l.l..u..t.t.oA....h.th...aG....l.......s.s....p.hs.....t...th.......p.lh....ssp.stp..................s..tht..................slph.hhh..p.....tphh..........t.h.....t.....h............sl.lhs.t+ThhDh......................................................................	0	204	424	536
+13181	PF13339	AATF-Che1		Apoptosis antagonizing transcription factor	Mistry J, Aldam G	pcc	Pfam-B_2199 (release 24.0)	Family	The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.	24.70	24.70	25.70	25.80	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.99	0.71	-4.00	65	310	2010-09-14 15:30:23	2010-09-14 16:30:23	1	4	266	0	215	308	2	134.70	26	27.10	CHANGED	DstKGh..AVcpQpphaDplL-sRI+LQKulssuNpLP.ptpshp.h..................tspptppslpssppsshpLhsslhsL+psLh................................tttp.spstpppKR............t.shschhpphpp....hcpphpsaRsslLpKWupK	.................................................................-spKGt..AV+pQhtlaDplL-hRI+LQKulsssNpLP..pspshs.h.........................ttspphppslcsspcsht..pLhps.Lh..sLpppLh.............................................................tttpttpttpppKR....................p.phshp.ch.pthsp....hppphpsaRspsLpKWppK..............................................................................................	0	68	115	176
+13182	PF13340	DUF4096		Putative transposase of IS4/5 family (DUF4096)	Coggill P	pcc	Jackhmmer:C2D5Z9	Family	\N	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.52	0.72	-4.12	381	3268	2010-09-14 15:35:10	2010-09-14 16:35:10	1	25	878	0	1120	3161	331	69.30	31	41.37	CHANGED	LoDppWshlpPlL...Ps..........tp....t.tt..........t..phspRpllsuIlalh+oGssWRsLP.pc..au..sap..TlappFpcWpcsGlapc.lh..p	........................loDtpWth.lpshl....Pt..........tp....t.t...........t..thctRtlls...ull.a....l.h....+o.Gst..WR.................t.LP..pc......au.....sap.....TlappFpc...WpctGsapplh.............................	0	323	715	905
+13183	PF13341	RAG2_PHD		RAG2 PHD domain	Bateman A	agb	Bateman A	Domain	This domain is found at the C-terminus of the RAG2 protein. The structure of this domain has been shown bound to histone H3 trimethylated at lysine 4 (H3K4me3) [1].	27.00	27.00	27.10	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.97	0.72	-4.00	6	1007	2012-10-03 17:27:21	2010-09-14 16:38:22	1	3	816	14	26	965	0	55.10	80	13.56	CHANGED	GYWIKCChuCpVD.NTWEPaYSTELs+PAMIaCS+G.uGHWVHAQCM-LoEohLlpLSQuNsKYFC.-HstLs+t..TP	.GYWIpCCsTCpVDlNTW.PFYSTELs+PAMIaCS+G..sGHWVHAQCM-L................................	0	1	3	10
+13184	PF13342	Toprim_Crpt		C-terminal repeat of topoisomerase	Coggill P	pcc	Jackhmmer:C2D5X4	Domain	\N	43.70	43.70	43.80	43.80	43.30	43.60	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.88	0.72	-4.34	157	1275	2012-10-03 10:42:43	2010-09-15 11:56:09	1	20	649	0	258	1109	139	62.40	33	11.70	CHANGED	psCsFplh+p.lsu+plopsplccLLppG+Ts.llcGFpS.KsG+pFsAhL.hlpts...pp............lsF-.Fsp	.......sCcFplh+p.lsu+plopsplccLL...ppu+Ts.ll+GF+S.K.sG+.sFcAhLhhpsc...tp............lsFpFt.........	0	74	171	216
+13185	PF13343	SBP_bac_6		Bacterial extracellular solute-binding protein	Bateman A	agb	Jackhmmer:Q7P755	Family	This family includes bacterial extracellular solute-binding proteins.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.57	0.70	-5.05	82	6234	2012-10-03 15:33:52	2010-09-15 13:11:13	1	13	2738	20	1426	11548	3747	237.10	19	69.13	CHANGED	sphsDllhu......hspthhpphhppshhp..............ssthsphst......tshtDs.cGtah..hhshsshlhhhsppplssp.h....P..psWsDLh.sPpacs..plslssss........shhpslhlslhp......phG.hcsstchhcshttsh+ssp...hschhsphpssp..........lslhshahsphhtppp.........shpllhPc-.GuhlsPhhhhlpps......ptctspthlcahhusc.htphhupsth.........hPs...........hpsshtsph.pstthphlsW-alppp	.....................................................................................................................................................................ADllhs....................hsss.h.t.th..t.p..p.u.l.h.t.s.hp.............................................st.t.h...s...p...l...s......................tthp..cs...p.....s..p..ah.............sh..s.......h.t....s.h....u....h..hh...N....p....c....t....l....p....p..........h.......P...........ps...a......p......D...L........h......c........s......c.........a.......+..s........c.....ls.hs.ssts..............tssshsh.l..tshhp.............................................................thG..tc...t...u..h...p...a...h.p....p....L...t......t....s..h......s.phs..........tsss.sh.p.t..h..t.pG-.................hs..l.s..h...s...a....h...h...s...h..h..t.t...ppps................sl.p.h...h....h......P.......p..........p....G.........s.....h.....h.....p.....s.......p......s.....s...ul..h+s...............upp......ct..A.cpa.l.-ahl...S.sc..sQ.p.h..h.spssh...........hPst....................t............................................th....................................................................................................................................................	0	374	805	1139
+13186	PF13344	Hydrolase_6		Haloacid dehalogenase-like hydrolase	Bateman A	agb	Jackhmmer:Q7P3Y5	Domain	This family is part of the HAD superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.11	0.72	-4.12	179	4798	2012-10-03 04:19:28	2010-09-15 14:26:07	1	25	3106	27	1565	3385	1469	102.30	28	34.77	CHANGED	hlhDhDGVLa....................p.......Gsp..s..lPGAs-slptLcpp.G........................hphhhlTNs..us+otpphtpcL..pp.l...G.ls.....h........s.t.c.....pllsSupsstphLpp..........t..............................spplhllGs..p.....s..htptlcphGhp	....................................................................................hlhD.lDG....sla.........................................................................c.........G.sp....s..lP.u.A.tchlc.t..Lppp.s........................hshlalTNs....ss+o.psls.p+L...pp.h...G.ls........s.................st..c......plhTSuhAss..c....alpc.............t...............................spp..l..allGp..t......u..ltptlpphGh.............................................................................................................................................	0	484	900	1295
+13187	PF13345	DUF4098		Domain of unknown function (DUF4098)	Coggill P	pcc	Jackhmmer:C2D3F5	Domain	This domain is a C-terminal repeat found in many bacterial species.	24.40	7.80	24.40	7.80	24.30	7.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.39	0.72	-4.03	289	4531	2012-10-03 02:33:51	2010-09-15 14:57:46	1	38	1424	0	1491	5507	345	72.60	17	44.79	CHANGED	shp..s.s..pl..plps.s..sG.s.lpl..p.s..l...pup....l.pl.p.ss..s..G.cl.plp..ss.pu.....shphpsssG.c.lp...l..p...s......phs...slph..p...s.s..sG.s.lp..ls	.....................................................................................t.......hphps.s.sG..s..lpl.....p...p...h......psp........h..pl..p..os...s...G..sl...plp.....ss.ps.............slp.l.p..o...ss.G..c...lp.........l....p................t..................tht.........php.h...p...s.....sG.pl...t................................................................................................................................................	0	607	1005	1297
+13188	PF13346	ABC2_membrane_5		ABC-2 family transporter protein	Coggill P	pcc	Jackhmmer:C2CY30	Family	This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.78	0.70	-5.03	126	1444	2012-10-03 10:13:34	2010-09-15 15:17:57	1	3	724	0	151	2276	340	201.80	18	90.65	CHANGED	uLllKDhh...hh+p....h..hhlh..hh.lh.hlhhhh.hh.....ptth...hh...hshh.shhhs..hhhh..h......ss......hp..hDc.p...sch...sthlhoLPlsRcplVhuKYlhsllhh....hluhll.sh.lh.......s.h.l...h..h...htts.....hsh..t.hhhh..h.hhshh..hs....hlh....hulhlPlhacaG.c+up.h.......lhhhhhh...s.......lh..h.....hhh...th...hp...h..........p..tl..........hht...hhshss...h.....hl.hh...hhhhl.h.lh...hhhlShhlSlpIap	..........................................................................Lhhpshh....hh+t.......h...hhl..h..hh..l.h..shhhhhh...................s...h......hh...........hs.h..h....ss...h..hh.....h.hh..h....h...........ps..........hp...h-c.c.........sch...thhlhoLP.ls..Rcpllh..u+..Yl.....h...sllhh....hh..u..h...l.l.s.h..lh...........................s..h..........h...l........lpss......................h..h........h.h.h.......s.....h.h..h.hh....h.h....hhh.....hu.l..h.....hP..h.....h.a....t....h..u.h...cps.p.h...........lhhhhhh..h.......................lh...h.............hhh....sl....ht...h...........................p..th...............................hp...hhsh.s.....h..........ll.hh...hh.hhl..s.ll...hhhlShhlSlpla............................................................................................................................	0	67	117	132
+13189	PF13347	MFS_2		MFS/sugar transport protein	Bateman A	agb	Jackhmmer:Q7P3E5	Family	This family is part of the major facilitator superfamily of membrane transport proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.27	0.70	-6.08	92	6648	2012-10-03 03:33:39	2010-09-15 15:21:27	1	29	2127	0	1465	15146	4138	393.70	22	86.65	CHANGED	p+ls.YuhG...s.hupshhhs....hhsh.alhhFaTDlh..Glss.......uhluslhhlsRlhDAltDPhhGhlsD...pop..o+aG.+a+PWllhuulshulshhlhF.........................................................................................s.P.shshss...........phha......................................h...hlsYhlh.slhYohh..slPahuhssslopcsc..-RsplsshRthhusl.us.hlssslhhsll..........shhussst.................................................................................................................................................................Gahhhshlhulluhl..hhhhshhss+E....................................tpppphshtphhcslhpNc.hhhlhhhhlh..hhhshsltsuhhhYahpYslsss...s...hhshhhh........hhhlssllusslh.sh.lsc+h...u++p.hhhhuhhlhhlshhlhhhhs...........sshhhhhshhslhshshshhh.hlhhshlsDsl-Yuph+..sGpRtpulhhuhhshhtKhuhAlusslsuhhL.shsGasuss.........s..posssltslphhhshlPslhhlluh.lhhhhYpLsc	...............................................................................................................................t..hh.YuhG......s..hutshh.hs..h.hhh..al..hh...a...Y.......T...c..l.h............G..l..ss.....................................shsGh....l.h....l..ls.+l...hD.A..l.s....D....P.h.h....GhlsD...............psp.......o+..a.....G..........+...h..R.P..........a..............l..L..h..u....s.....l.....s....h.u..l...h..h.h...l..h.F.........................................................................................................................................................................................................................................................................................................h.s.....s.......t..h.s.h.ss..........................p.hla....................................................................................................................................................s..........hlsah.l.h.....sl..ha.o..h.h.....sl..P..a.t....u....h....h..s..s..l...T...p......s.....s.p......c..R..s..p..l...s...u....a...R....h..h....h......u.....s..l...us....h...l..s.s.h.h.h...h.s..lh......................shh..u..s..s...p..t........................................................................................................................................................................u.a..h...h...h...s..h....l..h...u..l..h..u..h...l....h...h..h..h....s...h...h..s..s..+E.......................................................................t...t....t.....p.....p.......h.......s..........h........t.......p........t.......h......p.......t........l........h..........p..........N..........c.........h.........h.....h.......l........h....h....h........h....l...h......h..h......h.........u.....h...s.....l....h...s....u....h...........h..........h.........Y......a......h....p......a....h.....l..s...ps...............t.........h....h....s....h.h..hh...............................................................h.h..h....h....s.....s....l....l.....u...s....h...h...h......sh....l...s.c...p.h...............u+...p.....p....h.......h.....h....h....u....h...h....l...h...s...h.....s.....h.....h..h..h..h.hs...............................tsh.h..h....h...h....h.....h...h....h....l....h......s.....h....s.....t..........u.....h....h.............s......l.........h...s.h...h.....u.D...........s....l.-.as.......c.....hp.............s.G.....h..........R.......h...p...G.hha...u..h.h..s.h...h.h...K....hu..u.lu.s.h..h......h.u...hh..L.....sh.....h..G....Y.ss...............................s....Q.ss..t..s..l.s..lh.h.h....h....hh....h....P.s.hhh..hlsh..hhh.hh.a.lp.................................................................................................................................................................................................	0	457	814	1153
+13190	PF13348	Y_phosphatase3C		Tyrosine phosphatase family C-terminal region	Coggill P	pcc	Jackhmmer:C2D3Y7	Domain	\N	22.00	22.00	22.10	22.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.15	0.72	-3.86	223	1604	2010-09-15 14:47:59	2010-09-15 15:47:59	1	18	1059	3	505	1321	176	65.90	20	23.01	CHANGED	ph..hpph.tt.tstspthhp....h.....hhss...p..tp.al.pssh.stlcppaGuhcsYLppslGlsspplppLRpphL	.........................................tht.................ht....hts.....hhss....c...tc.alpssh.ptlcppY.G..uh-sYLpcslGloppplpp.L+phhL............	0	153	323	426
+13191	PF13349	DUF4097		Domain of unknown function (DUF4097)	Coggill P	pcc	Jackhmmer:C2D3F5	Family	\N	23.00	22.60	23.00	22.60	22.90	22.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-11.41	0.71	-4.70	53	1584	2012-10-03 02:33:51	2010-09-15 17:17:30	1	18	1137	0	191	1342	30	157.20	17	50.57	CHANGED	KKh.lhhuhslh...ll.....Gsll.hhh.u..htssu......h.a...spt..pltp..................ppph...cslsplsl.psss.sslpIpp.ussppl..pl..ph........ppp..........hpl........ptss.spLpl.ppp.tpp.hhhh.......shsht......t..tpsplplplPcsh....phs....slplps.s..Gsls...lp.s..l.phc.sl..p.ls.s.su...slphp	..........................................................................hhhh...lh.....uhhh..hhh...s...h...s..................................h.p....................................phsht...pshc..plpl..s............hss...t............s..lplpp..us.s.p...pl..cl..ph.................psp.................lph.................p.s.s..psLpl..ssc....tt...hh....................................hhphts.................tpppl......sltlPcph.........................lc...................plslps....s.......sGslp........lps...l..shc..sh..s.lp.s.ps..G.pl.......................................................................	0	72	121	154
+13192	PF13350	Y_phosphatase3		Tyrosine phosphatase family	Coggill P	pcc	Jackhmmer:C2D3Y7	Family	This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.13	0.71	-3.99	403	1860	2012-10-02 20:12:17	2010-09-15 17:39:40	1	30	1165	3	645	2255	428	158.20	28	56.25	CHANGED	NhRDlGG............a...st............sGp...pl+hGhlaRSusLspl..o.s....s.DhphLt..slGlppllDLRsstEhppp....P.........c.hhh....s......usp.h.hpl..slh..sss.s.s...........................tt..h.t...thht.t...............t...t...stphhtch..Ypphlps....t..tss....appl..hchlts....s.s...s...slLaHCoAGKDRTGlsuALlLthLGV.sc.-s.IhpDYlloN	......................................................................................................................................................NhRDlGG....................................h...st......................sGp..pl+.shlaRSu.p.L...s.p.l....o.p....t.Dh.t.hL....t...p.....hsl.ptlh...DhRo..s.tEhptt......P.................................s.....h..t........ss.p.h.hth..s..lh..stttt..................................................t..h.t...t.htt...............tt.s.phhhphY.p...p.h.lpst.........pps....apph..hp..h.lhs.................ss....s.....sllhHCo.............AGKDRT..Ghs.u.A.L.l.L.t.h.L.....G......V.sc..cs.Ih...pDYlhop.......................................................................................	1	218	425	550
+13193	PF13351	DUF4099		Protein of unknown function (DUF4099)	Ellrott K	pcc	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. The C-terminal repeat region of this family is DUF4098, Pfam:PF13345.	22.00	22.00	22.50	25.60	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.61	0.72	-4.09	51	427	2010-09-15 16:54:58	2010-09-15 17:54:58	1	5	128	0	40	345	4	84.10	31	20.97	CHANGED	ap.pclsWcpLc.phGlo+EpLEp.stp.L-plLpGt+os.llslphshsss.tl.ph-A+LulhpspsG.plsltlaslpp.pspL-p.hh	.....hc.sclsWppLc.phGlo+-p.LEp.ssp.L-phLpGtKos.llslp.hshsst.sh.ph-ARLuhhpss-G.plslshHslRc.c.pL-t...........................	0	13	35	40
+13194	PF13352	DUF4100		Protein of unknown function (DUF4100)	Mistry J	jm14	Jackhmmer:Q05Y37	Family	This is a family of uncharacterised proteins found in Physcomitrella.	21.40	21.40	21.70	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.37	0.70	-4.89	15	2840	2010-09-16 09:21:40	2010-09-16 10:21:40	1	6	1	0	2840	2906	0	132.50	52	29.62	CHANGED	AYIAKSQHEALMEEKRRGNFDDTREGNSSKRQTRGDKAREAASQELPVKDTSsSLtEKTKETKDKGKSIAYKLLSDIEAATNLKGVLEE+ILNAKlEFtLKElLtIsKKEFHDVIIDSIK+KRQLMuEstMsHAIDARIY+DEEEV.D.sYKQsTNEKNuYNQRVRFED.SDKEhEshSHYTRKHWARsTTEVLVKVGDIEEPIVALVDHGSE	..............................................................................................................................................................................................................................................................................................................................................................................................................................................h.....t...hpssh.shKt..........hL-.Ep...l....Lss.KlEFhl+-hLt..IsK.+-.....Fa-lI....I..ssIK...p.Kp.................................l.h......c-.E.E.E....l...s.........h......t...p...........h.........p....p...................t...............................................................................................................hhhc............................................................................................	1	2840	2840	2840
+13195	PF13353	Fer4_12		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:C2CYL4	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.03	0.71	-4.06	147	15922	2012-10-03 08:56:43	2010-09-16 11:21:53	1	90	4368	5	3584	16094	3629	134.80	18	43.59	CHANGED	lNGsG...s...R...s.....oLa..VSG..Cp..+..pCc..G..C...aN...pssW............shs....................tGp.a...s.....pchpcpIlppLp...s....shl......pGLol.GGEPhh....Nt..p..sllpLl.++l+pch...s...sKsIWhaTGYph-.cLt......p....p.........ppclLshlD...V.LVDGcFh.psht.D.....s..Lt.aRGSuNQ+lh	................................................................................h.h....h.p...s...Cs..h...........cCt.a......C............h.s.........p..s..h..............................................p..h..p........................................................................t.s..p.....h.........o.........p-h...h.......c..p....l...l...p..t.h.t.........p..........tth..............ts.l.s...l...o....G....G...E.....P.h..l.......th.......p...hl.h..c....l.h....p....t....h....+....p.ps...............h............p.........h....h......h....p...s....s.G...h....h....h.t..p.h...................................h.th....h....p........h...s........h........l....D...h..................................................h...........................................................................	0	1305	2427	3058
+13196	PF13354	Beta-lactamase2		Beta-lactamase enzyme family	Coggill P	pcc	Jackhmmer:C2D5A8	Family	This family is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.14	0.71	-4.87	138	5244	2012-10-02 21:13:33	2010-09-16 14:09:41	1	27	2386	268	694	10619	1975	200.40	28	66.42	CHANGED	lss..sp...hh...sh...sscph.hssASshK....l....s....l....h..........ptlp....p.....Gcls....Lsc.....plphp.p..pp.......h..s..s..Gu.....Ghhp.hh..s..s.s..p..holp-LhphMlshSDNsAoNhLlchl....G.hps...lsphhpp.hGhps.stlpph......h.........................................................shp...t.....t...p..N.....to..osp-hspllp....tlhp....s..............p..h.ls................hp.......h........l.p.p.....pth.....p.p.t.ls...ts.l.s..............ps...h...p.lu...pKoGs.......l.ss.....hppD...sGll.hh..ssps.allul	...................................................................................ssp..h...sh...ps.c.c+.ash.sSThKlh....l.s........................ttl...........t...........s.p...p....Lsp.....p.l.p..hp....p...s-........................l...s...p......ho.......s..l.hc.....+t....h.....ss...s...h...olt-..L..s..p.u..s..lphS.....D.N.....s.A..s.....N.h.....L....l.p.....pl.............G.Gs......p....t...................l..s....s...h.......h.......+.......p.......h...G...s.......p..s...s..p...lc+h.......cs............................................................................................................phs....ths....s...st...c...c...............oooPtu.hup.s.Lc....pl.ht.....s....................................p..h.Ls.tpp.......................t.lhp...h......................ht....s............s.ps......s...t..h.....lp....us.lP...........................................tsh...h....l.u..c.Ko.Gs..................t.hs.......s.ps.p......luhlhs..stts..hhls......................................................................................................................................................................	0	200	452	595
+13197	PF13355	DUF4101		Protein of unknown function (DUF4101)	Mistry J	jm14	Jackhmmer:Q05S35	Family	This is a family of uncharacterised proteins, and is sometimes found in combination with Pfam:PF00226.	22.80	22.80	22.80	22.80	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.43	0.71	-3.69	63	153	2010-09-16 15:48:57	2010-09-16 16:48:57	1	4	101	0	70	172	95	115.10	26	17.52	CHANGED	AppllppWLssKupshussas.hs.....tLppllssshlsp.hpppsp.........thpppstahpa..hphplpulph.sps...sppst...lcAplpEpsphhs.sGphpsp.ohsssh.pV+Y.Ls+p.ssp.W+Ips	............AppllppW.ssKupAhGssap.hs......tLpplLssshLpp....hppput....................thpppshaapat.hplplpslph.sss....sppAt.lcAplpEssplhs..sup.ppt.ohpssh...pl+YpLt+p....sst.W+Ip..................	0	14	49	65
+13198	PF13356	DUF4102		Domain of unknown function (DUF4102)	Bateman A	agb	Jackhmmer:B3CUZ6	Domain	This presumed domain is found at the N-terminus of a wide variety of phage integrase proteins.	27.00	27.00	27.10	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.12	0.72	-4.10	255	5922	2010-09-17 08:49:24	2010-09-17 09:49:24	1	16	1625	5	949	4352	701	86.60	34	23.48	CHANGED	LT.cptlc.........sh..psps........pp.......htht..D.......t.........GLh.lpVp.s.s...G...sK..sah.hcY................ths..G+..pp......p...h.sl..Gpa....Ps..................l......oLspARppspchpthl.s.p.GhD..P.ttp....+cppct	.....................Loctplcsh....KPpc........K......hpls.....D.....G.........tGLh..Lh.Vp....s...s............G.......s+...hWp..h+Y.................+hs....GK........pc........p...l..ul..G.sY.......Pp.....................l......oL...u.-ARppt.p.c.h+phl.u.p..Gh.D...Ptpp+pttp.h.............................................................................................	0	174	512	736
+13200	PF13358	DDE_3		DDE superfamily endonuclease	Bateman A	agb	Jackhmmer:B3CQR6	Domain	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.93	0.71	-4.45	69	7080	2012-10-03 01:22:09	2010-09-18 09:34:17	1	125	1242	0	3290	6631	624	121.10	21	54.12	CHANGED	pllahDE.sshphph.thttuas.pGpp...h.htstt+tp......phshluA.lshps...hhsh.hhh.......................................ps.shsuptaht.alcphltshhp.................thhllhDNss..hH+u........ptlpph..........lps...............................sshplhaL.....PsYSP-LNPIE.thWuhlKppltp..tthpshcslp	.........................................................................................................................................................................................................................................................t...............h....hhus...hp.....tt......h......h.h......................................................................................................................................................................................tt...thst..t...h.....t...hl.p..p.h...h..........h..p..................................thhllh...D.Nss..............hHps....................................pt.lp.p.h................hpp..................................................................................................................................tp...h.p.....l.h.h.h.......P.s.a.S.P.-.L.N.P.IE..phWth.l.+.p.phhp.............h..................................................................................................................................................	0	1274	2326	3074
+13201	PF13359	DDE_Tnp_4	DDE_4;	DDE superfamily endonuclease	Bateman A	agb	Jackhmmer:B3CSL4	Domain	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.86	0.71	-4.63	61	3886	2012-10-03 01:22:09	2010-09-18 10:01:42	1	51	549	0	1579	4471	221	120.50	28	53.91	CHANGED	lDsocl.l..ppPp...s........pstsasthKppp........olphhl..sssssGhlhh.lstuasGpssDpplhppS.shhph.......................ss.chlluDpuFs..hpp.........h.hshpt...........tttpl.sspc..tphNpplu.phRhhVERshshlK.paphL...pptlthp.............hpphsclltssssLpN	...............................................................................................................................................................hph.h....h........s.s...p..hp.hh....h.h.....h.....s...........h......pDh..p..l..h.p.......u......h................................................................s..hh.hluD.u..GYt.....sh...........tl..................sPh+t..........................................................phps......L......sspc......cthNct..l.u....p......t.............RthlEp.hhup....lK...pa+hh.....ppthc.p.....................hpphsh.h.h..h.hsslhN.............................................................................	0	715	1056	1438
+13202	PF13360	PQQ_2		PQQ-like domain	Bateman A	agb	Jackhmmer:B3CRY3	Domain	This domain contains several repeats of the PQQ repeat.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.25	0.70	-4.91	112	7855	2012-10-05 17:30:43	2010-09-18 13:57:24	1	358	2271	34	2581	8458	4130	182.50	15	45.19	CHANGED	spupl.tuls...t....sGpplWpt.....sh.t...........................................s.............huuGl..sh.sssplhls...s.......stuplhulcsssGphlWpppl..suthhus.....................P.hlssspl.....hlhs...........sDs..plhu.....ls.spsGch.......................hWp.hpts.......s.sshs..ltussssshs....sshl.....lsshs.....uGcl...........hulshpsGph..hWptsl.utsp.............tssphp....plsDlsusPlls....ss...plhssuhpG....p...h.....ssh.-htsGp....hh.W.sps.huu................hps.shsssshlahss.p...................p....uplhslctpsGphhWpp	..........................................................................................................................................................................................................t..................................hWt............th....................................................................................ts.h.......s.h........s..s...h...l...a...hs...........s....................tp.s..t.l.h..A..l...c..s.....t...s....G......c......h....h.....W..p.h...ph......ss.t.h..tss...........................................................P...s..h....s...s...s...tl......................hlss......................................tsu..........pl.hA...............l.....s....tts..G.ph..........................................................................................................hWp......................................................t........h.........s....hh......................tthh......................h.h.s.................................ss....l..........................................sh...t....t.....p...G..p........hh...t.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	857	1659	2192
+13203	PF13361	UvrD_C		UvrD-like helicase C-terminal domain	Bateman A	agb	Bateman A	Domain	This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null --hand HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.30	0.70	-4.99	35	17009	2012-10-05 12:31:09	2010-09-18 16:32:58	1	133	4760	29	3900	14321	6091	300.30	21	37.70	CHANGED	lpLEpNYRSstsILpsANplI.............................ppsppchpK...tLhsspssu.pplphhpspscpc........EAchl...spcItp...............htpp....shp.hpDhAlLhRs.NtpucslEcsLhpts.IP......Y.clsGshpFa-RtEI+DlLuhL+.llsNspDc.............hulhRllssPt.+G....IGssolppltp..hspppplshhphh.............................................................................................................................................................................................hh.ttlstcstptlpsFhphl........................pphp.p..ht...hshpphlcpllcctsh.hphlppt.....cpucp+lpNl..pcL..hshhcca..............pp.t.................p.tsLhsFlpchsLpsptpcpp.......tpt....st.VpLMTlHuuKGLEFPhVFlsGh....pcu............................................hhP.............................ptpuh..tptcplp...EERRLhYVulTRAccpLalotspp	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LppNaRSp..tllphs.s......lh..........................................................................................t..t......t....................t............h...h..................t....t...t.....t.................t..........h............h.....h..............h........s....t...t......................................c...s....p..h...l.......st...p..l.p................................................................................h.tt.........tht..hp-....h..AlL...h.....R....s.....p.....t.........p........s...t..................h...p....p....h..h....h....p.....t.....l..P...............h...hh...s..t.......p..h..h..p..p.......p.l.p.t.h.......h.s.h....L.p.....h.l..........s..............p...p................................s.h........t.h..l.t..........sh.....h.......t.......h..s.........t.p....h..t..l.......................................................................................................................................................................................................................................................................................................................................................................................t..........................h......t..h....h...t...h.h.....................................................................................t...th...t...............................h...h....t...t....h....h..........p.......t..............t....h........p...h.h.tt.......................tst.t.ph..t..s....l......tth.........hp.h.h.p.ph.......................................................t....................................................................................t........t....l..........t...h...l...p.....p......h....t......h........t..tt....ptt................................tt......................st..V....p.......l...h.......Tl........Hsu...KG..LEa.s..h..V.....a.l....s..s.....h.......pc...s..........................................................................h..hP.....................................................................................................................................................................................................................t.t.sh............p.tpp..l..p..........E..E.....p......R....LhYVulTRAccp.Lhlsh...t...........................................................................................................................................................................................................................................................................................................................................................................................................	0	1318	2605	3363
+13204	PF13362	Toprim_3		Toprim domain	Bateman A	agb	Jackhmmer:B3CQ99	Domain	The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation [1].	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.30	0.72	-3.75	51	1268	2012-10-01 21:47:57	2010-09-18 17:02:44	1	39	840	0	288	2429	926	98.00	25	17.03	CHANGED	hlhlsEGlEouLSl....htshsshsshAshus..sslp......slths..t.thccl..hlstD.sDss...........GppAstcl........sc+hps.tuhpstlltP........pu........DaND..slpptGtc	..........................................lhluEGhtTALol................thhss.h.ss....h....A...s.h.su......s.p.Lp.....................................sl.ths.......t..ss..p..pl.........lIs.u.D.sDhs.t...............................Gpp..su.pph.....................s.pt...h...t...t.........s.....h..t..sh..h..l.P.................shs..................DaND...hhpt.G.............................................................	0	65	161	226
+13205	PF13363	BetaGal_dom3		Beta-galactosidase, domain 3	Bateman A	agb	Jackhmmer:Q700S9	Domain	This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain has an Ig-like fold [1].	27.00	27.00	28.80	29.80	25.70	26.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.52	0.72	-4.59	56	193	2010-09-18 17:35:32	2010-09-18 18:35:32	1	10	99	6	137	210	0	80.10	32	8.04	CHANGED	WsPsl.ssss.s.......sp.sllVpGsYLVRoAslp....G..ssLpLsGDhsso.TslEVaus.p.slpslpWNGcclpsspos.hGslpu	...................Wss.h...spss.s.............sp.sllVpGsYLVRoAslp......GssLpL....pGDhsso.....TslEVh..........us..p..slpslpaNGcplptp.psp..Gshh............	0	39	74	112
+13206	PF13364	BetaGal_dom4_5		Beta-galactosidase jelly roll domain	Bateman A	agb	Bateman A	Domain	This domain is found in beta galactosidase enzymes.  It has a jelly roll fold [1].	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.92	0.72	-3.80	105	562	2012-10-03 19:46:52	2010-09-18 22:23:13	1	26	198	12	334	675	18	112.50	22	20.36	CHANGED	Ys-p..uW..ssss..sos.........s...sss.........hsu...hpsGsthYRspF......p....h-..hu....hp.............stsusuat.........splalNGh.hGp.as......shusp........ssaslPp....slLsh.....p........stlhsslhspsuts	................................................................as-p..sW...........sshs..sst...............ttss.........hss.....p...sG.shaYRupF................s.u.ths......hshp.............hs.spuus.s.ht.........splalNGh.hGp.ah.......sshGsp.......................ssaslPp..ulLsh...p........sslhsslhs..t..............................	0	96	180	272
+13207	PF13365	Trypsin_2		Trypsin-like peptidase domain	Bateman A	agb	Jackhmmer:C0AF95	Domain	This family includes trypsin like peptidase domains.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null --hand HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.06	0.71	-4.12	318	12156	2012-10-02 13:45:52	2010-09-19 13:18:49	1	253	4752	80	3773	11497	4680	143.10	28	31.28	CHANGED	GoG..h....ll...ssss............................hllT.s.................tHVlp...................................................................ts.pplthhhhsspp.ht...................................................uplhths.....t.................................hDl..Allplpsstttthshtssstthtssthhhhhh.......................................................................................httstshhhttthtstttttstphhhh.........................sssht.s.....GsSGuPl.hs...ppGp...llGl	..................................................................................................................GSG..h...ll.....sp.s.G...............................allT.N.................sHVls...................................................................................................................suspl.p....V..p.h.scucp..hs.....................................................................................................Acl...l...G.tDs....p..................................................sDl.All+lpssphhshhhhsss....................................................................................................................................sthshsssssshh...ssss.hhs.s.h.s.t.s...s..s..t.t.t......tp...h.....................................l....QTDA.u.IN..s...............GNSGGsL...lN....hpGc...llGI............................................................................................................................	0	1232	2423	3164
+13208	PF13366	PDDEXK_3		PD-(D/E)XK nuclease superfamily	Bateman A	agb	Jackhmmer:C0AD98	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily	22.00	22.00	22.00	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.26	0.71	-4.04	106	398	2012-10-11 20:44:47	2010-09-19 14:41:19	1	8	204	0	173	467	252	110.60	36	80.21	CHANGED	p-loppIluuAhcV+ppL.GsGhLEsVYcpuLthELpppGlshcpQhtlslhY+uhhlsp.apsDllV........psplIlELKu.VcplsshHpAQllsYL+hos..........hclGLLlNFss...h+.t.......h+Rl	.............................t.plshtIlssuhcVappL.GsGhLEslYcpsLhhEL.pppGlthpp...Qh.ls.lhY+s...hh..ls..p.a+hDllV........psplIlElK.u......Vc...p....l....t......s....hHpuQllsYL+hos..........hclGLLl..NFss....p.thpR.......................	0	96	155	171
+13209	PF13367	PrsW-protease		Protease prsW family	Coggill P	pcc	Jackhmmer:B0SDU2	Family	This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. Swiss:B7GHM8, PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Swiss:B7GHM8, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress [1].	21.50	21.50	21.60	22.00	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.73	0.71	-5.11	184	1339	2012-10-01 21:07:14	2010-09-20 14:09:30	1	22	1111	0	303	941	360	189.90	23	55.85	CHANGED	pPhthllh.sFlhGshsuhh......shhlp.......thht..............................hh..hhts.hlhusllEEhsKhlslhhhh.......h.htppph..........sp...hD.Gl.lhusssuhGFAhhENlhYh....h.............................................shhts......hlhR.slhu.shuHsla...ouhhG..huluhst...htt...........t.....hhhhhuhl...huhhlHulaNhhhhh..........................hhhhshhhhl	.................................................................................hhhllh.shhhGshhuhh.......shhlp......................................phlh..h.........................tth.s.tshtsslsusllEEssKhlsllhhl..................................h...tthch..........................................spl...hs..sl.lhG...sss....GhGFAhhEslsYhhp.h...........................tt.s.........................sslsh............................hlhR..shhu.lsuHhla.oul..sG...hulslsh................pptt.............t.hp....hthhhhhl...hAhslHhlass.hsh.ts..h...............hl...hhhh.h....hhhhh..................................................	0	113	225	277
+13210	PF13368	Toprim_C_rpt		Topoisomerase C-terminal repeat	Coggill P	pcc	Jackhmmer:B0SHF2	Domain	This domain is repeated up to five times to form the C-terminal region of bacterial topoisomerase immediately downstream of the zinc-finger motif.	22.30	22.30	23.10	22.30	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-9.05	0.72	-3.49	42	3284	2010-09-21 08:44:24	2010-09-21 09:44:24	1	25	1144	0	1046	2994	3373	67.30	30	21.53	CHANGED	cPtsG.c.sh.V.+-GRFGPYV.....TcG...csN.....s.oL.+s..sss-slT...hccA............hp.LLA.-+.cA....+usu...+...K....p..s.Ap.K	............cPtsG.c.l..l..psGRaG.PY.l.....................p.c..G...........pss....................................u.oL.+...s.......ps......s..tslT........L-cA..................................lc.Llu...t.....+t...........tu.t........................ts.............................................................................	0	338	755	931
+13211	PF13369	Transglut_core2		Transglutaminase-like superfamily	Coggill P	pcc	Jackhmmer:B0SCJ3	Family	\N	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.91	0.71	-4.72	183	1446	2012-10-10 12:56:15	2010-09-21 10:38:47	1	21	1341	0	427	960	170	155.40	32	47.73	CHANGED	pthhtpLcplstcscpp.....lstp........................................................p........plp.tLtchhapchG.....FpGspp....sYhssc..........Nualsp.......VLcpRp..GlPloLullaltlAc+.lslslhuVsh.PscFll+ht.........................hhl-Pas.G.c....hlstppl.pthLpthhs............hp....hpsp.....hLp...sssspplltRhLs	......................................................................................................p..hhscL-pLsp.scpp.............lsp.......................................................................................................................................................hs.cp.............plc..tLhplFY..t-..h.G......................................Fpu..sps.......sYh.s-.................sha.Lcp....VL..c..p..Rp..G.slSL.......uslhLh......lAp+..LsL...PLhsVh.F.....Ps..p...h.lLRhp.....................s.-sp.........................hhIsPFs.G.c........pLspctL...chhLcsphus............sc...lh.p............Lp...tAsshpllt+hL.s.............................................................	0	135	239	341
+13212	PF13370	Fer4_13		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:B0S9J0	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.09	0.72	-3.58	110	1093	2012-10-03 08:56:43	2010-09-21 10:44:49	1	12	947	18	263	2183	451	59.60	39	58.75	CHANGED	V......D..ssCIsCssCtthAPclFphssctttshl.h......c..........p....sp..s..........pp-.....p.....ppshpAhtuCPssuIts	.............VD..-pCIA.CG...tCsshA...P..-...l....FD..a.-.D.-...s...ht..hll.h..........-.................c...sp..s....................-c............h........-shh-A.hc.uCPTcuIc.............................	0	91	192	235
+13213	PF13371	TPR_9		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:B0SCJ3	Repeat	\N	21.00	8.30	21.00	8.30	20.90	8.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.09	0.72	-4.12	103	4976	2012-10-11 20:01:03	2010-09-21 13:12:18	1	1320	2289	0	1951	43963	9522	67.30	16	14.49	CHANGED	LKthh.hppcchppALpsh-hlLhl.....tPc...ssh-hRDRGllhtpLsshpsAhpDLptal....ppsP.....pssssphlctplp	...................................................h.........ttp.h...p.A...h...t....h.h..p.....t..h...l..t..h.........................sP.p.................sst....h.....h.......h.......p........p..........u........h.....h....h.....h.......p.........h........s........p.......h.....p....t...A...h..p..s......l...p.t..hl............p.p.s......................pt.....................................................................	1	652	1138	1559
+13214	PF13372	Alginate_exp	DUF4104;	Alginate export 	Coggill P, Eberhardt R	pcc	Jackhmmer:B0SIJ8	Domain	This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel [1].	25.00	25.00	25.00	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.22	0.70	-5.85	23	682	2010-09-21 12:51:04	2010-09-21 13:51:04	1	7	487	4	258	716	125	365.20	17	76.18	CHANGED	shlshGhslRtRhE.hssssthGstsstcDshllpchplaA-hchss....phphhlphpDsRsaspp.................sssssD..pNtlDlcpAals.......as.ssLs.stshc.lRlGRQchshstpRa....Iusp-h.NsppuFDulhhcac..s....spaRhpuhhspPsphhssph.s........DspscshpFsusphphps.hsssslpsYasthpcpsup..........................hhcssssc+hpshulRhsGpt.......sthDa-hEuhhQoGps....Gspshcua............AhuucsG..YTh.shshpPRlulphDhASGD........pcssDGslpoFssLFssut....aauhAshsuhuNLhpspsplolpP....ssplsh.suhthhWRtsssDulhspstss..............l.ssuGpuu.casGpthclR.............hc.ahhssphthtlcuuaFpsG-sl+susspssshsssp	...........................................................................................................................................................................................................t...phshphR.cht........p.t..........h............................t..t..s..t...t......h......h.........ph...thh.h..hphtt....................thphhhph..ss.h.h...st..t..............................tss-.......ps.thslpp..uahp............hp...tht..........s.....hp....hphGRQph......ths.s...p..+h..................l..u..s...hs........h...ss...t.p.s....a.D.uhththp...h.....................sphp.h........s.h...h...h.h.....p...s.............sth....................................cst..s.t..p.pth.h...s.....h...h....h......p......h.........p...............h......t...........h..t.......h.....p...s..ahh.thp.pptst..............................................ht...t..t...t..s.p.p.hpshGh.+htuph.................tths..a..phphhhQ..t..Gph...............sspshpuh................................uhts..p..h..G......a..ph...t...s.h...pP......ph..s.......h..th..sh...h.....SG.s..................p.t.ss.p........h.t.sF......p.sh....a.sssh...........................hhu...h..th...h.....t...........s.......N......l...sh..t...th.phps.......ptph.shthth.hh.hhh...pttsshhtts...............................................st..p...hGt.hph...........................hp..a.ht..ph..hththshh..up...hht..t............h.................................................................................................................................................	0	94	183	221
+13215	PF13373	DUF2407_C		DUF2407 C-terminal domain	Wood V, Coggill PC, Bateman A	agb	Pfam-B_17915 (release 21.0)	Family	This is a family of proteins found in fungi. The function is not known. There is a characteristic GFDRL sequence motif.	25.00	25.00	25.50	26.50	22.50	24.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.98	0.71	-4.26	28	151	2010-09-22 10:47:12	2010-09-22 11:47:12	1	7	140	0	116	144	0	129.40	32	39.30	CHANGED	hGFDRLLssGFoppElssLRpQFhulaus......ppss-shss.p..............slRpLE-pWh-ssus..................................tssts.s.ssphss.........hsssstps.-DLLhGhllGhFhGlhuhlaLh+--..Glas+Rp+hulhsGlhlNhsauhlRs	............................................pGFDRLL.ss.GFotpElstLRpQFhuhh.u......hppss-shssss...................clRpLE-pWh-ssus......................................................stss.s.tsthst................hssssttshcDhLhGhhhGFFaslhshhaLh+pc..ul..astRpphulhsGlhlNhhhuhh+.....................................	0	38	68	100
+13216	PF13374	TPR_10		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:Q7P422	Repeat	\N	22.00	10.00	22.00	10.00	21.90	9.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.76	0.72	-3.89	291	5651	2012-10-11 20:01:03	2010-09-22 18:02:07	1	1557	998	7	3285	40335	8366	38.20	20	7.91	CHANGED	shsshssL.At..hhtpt.uchpcA.pplhcp.s.lphpcpl....hG.s.....cH....ss	....................................shpsL.ut......hh....tp....t..G.....c....hp.....cA..t...sl....hpp.s.lt.htpth...............................................................	0	1339	2317	2944
+13217	PF13375	RnfC_N		RnfC Barrel sandwich hybrid domain	Bateman A	agb	Jackhmmer:Q7P7C9	Domain	This domain is part of the barrel sandwich hybrid superfamily. It is found at the N-terminus of the RnfC Electron transport complex protein. It appears to be most related to the N-terminal NQRA domain (Pfam:PF05896).	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.17	0.72	-4.29	96	1912	2012-10-02 20:27:15	2010-09-23 09:15:51	1	35	1463	0	364	1936	307	94.90	37	16.91	CHANGED	hsF+.GGlHP.s-s.KphS.pspPIpph...hspclllPLpQHIGAPucPlVphGDcVLpGQhIucu.s.G.FhSuslHASsSGsVpuI-.+sssp.uo..t..s..p..sllIEsDGc	........................................................th..GGlH..P..c...Kt.o.pttslp.ph.s....h.s..p.c..hs.l...PL..p....QH.....I....G......A........s.up..sVpsGD+Vh+GQh..lscu.....p......G..hh.....ss...PlHAssSGsVsu.Isspsss.p.ss.t..h......slhIpsDu.............................	0	145	261	317
+13218	PF13376	OmdA		Bacteriocin-protection, YdeI or OmpD-Associated	Coggill P	pcc	Jackhmmer:B0SHC2	Family	This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice [1]. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S) [1]. YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein [2].	22.40	22.40	22.40	23.10	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.59	0.72	-4.32	168	1185	2012-10-03 20:18:03	2010-09-23 13:04:02	1	11	931	0	364	981	110	61.90	27	33.61	CHANGED	spshplP.sDltsALpssspAtthFpslstst+pshlthlt..sAK+scTRt+Rlpchlphlscsc	...............t...h.lP.p-lpstlp..ppPth.tstFpsLosutp+palhalt..sAK...pscTRp+Rlpchlphl.pG............	0	160	276	335
+13219	PF13377	Peripla_BP_3		Periplasmic binding protein-like domain	Bateman A	agb	Jackhmmer:C0AC70	Domain	Thi domain is found in a variety of transcriptional regulatory proteins. It is related to bacterial periplasmic binding proteins, although this domain is unlikely to be found in the periplasm. This domain likely acts to bind a small molecule ligand that the DNA-binding domain responds to.	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.04	0.71	-4.24	246	26367	2012-10-02 13:57:41	2010-09-23 13:14:04	1	51	3428	168	5469	22392	1655	160.60	23	47.18	CHANGED	scaL.hppG.a++lu....hls..............sttt..hsptRhpu........atpth.pptsht.sphhhhhttttt.tt..t..............................................................s.....s....Alhs..ssDthAht.lh.pshpp.t............Glp..l.P.cDl.ullu.hs........t......hh..phssP.sL.....o.olph.shpphu.ppAschLhph...l.......tstpts.pp.....hh.hss.p.llhR.pSs	.............................................................................................................................paL.lp.t.G.+.c..c.Iu....hls.............................sstph.tsspp.R.h.pG......................app...uh....p..c.t..s.ls...h...st...t...h..h....h..t...s...t......s...t.t.s.s.httht....................................hl......pth...............................................ts...........s......Alhs...ssDt.h..Ah..G..s.l.ps.h.p.c..t...................G.lp.........l....P....c.........D.........l...u..ll..G..aD.............sh.........hu....ph...h....p..P...sL........................T.Tl...p..p..s..h.p.p...h.G..ppAschLlpt.....l........................pt..t.p....h..s....pp.................hh....lss..p.LlhRpSs....................................................................	0	1692	3369	4443
+13220	PF13378	MR_MLE_C		Enolase C-terminal domain-like	Coggill P	pcc	Jackhmmer:C2D1R2	Domain	This domain appears at the C-terminus of many of the proteins that carry the MR_MLE, Pfam:PF01188 and MR_MLE_N Pfam:PF02746 domains.  EC:4.2.1.40.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.44	0.72	-4.09	1015	7138	2012-10-02 01:07:48	2010-09-23 13:18:26	1	22	2468	500	1681	7613	3271	111.80	23	28.55	CHANGED	sEp.h...hshtshpphlp.tsu.s.....t..h.lphcls+sGGlspsh+lush.Acshslt...lhsHs......ssluh.suslp.l..sssh.s.............s......hs..........h.h-................hh...h.............tph....ht..............s.h........s.Gh...l.tl..P.....t..P.....GLGlc	..................................sEhhtshhpht.phlp..ttu.l....Dh..lphchs+sGGlstsh+l..Ash.A.ct.a.s.ls............hssHu......ssluh...utshH.lss..ss..s............s...........hs.......h.pE............t.h.t......................ch........lp..................s.h..t..hc.s...Gh...l.ps...s..p....t..P...GLGlp...........................................................................	0	405	960	1336
+13221	PF13379	NMT1_2		NMT1-like family	Bateman A	agb	Jackhmmer:C0AC77	Family	This family is closely related to the Pfam:PF09084 family.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.43	0.70	-5.00	82	4162	2012-10-03 15:33:52	2010-09-23 14:15:53	1	25	1726	8	1437	7965	1155	236.20	18	65.58	CHANGED	ssPEpspl+lGFIsLTDsAPL.llAtcpGaap+a....................Gls.l..plt+puSWussRDpll....sGplDuAHh.LhshshhhphGh...su.thshhsLhsLshNGpuIslusphhsthh..............hssssl+thhtp.pt........tshphAhoFPsuTHshhlcYWLAusGlcP...............pDlphlllPP.PQMVushcsGsh-uaCV....GEPWstpAl.tcslG..assh....oot-l.......WtsH..PEKs......husptcal-ppPssspAlltAll-AspahD..sstN+pcsApl.l....u	................................................................................................................t......tlp..lG..h...........h.h...t....h..h..sh....h....h.....u.t...p.....p.....s.h.hpct......................................Glp..l......phh...p..h.s...u...s.s.s...l..h..p.....ulh...............uG.plD..h..uth..hss..h..h...h...s.h.s.t.Gt......................s.h..h..s..h...s......s.....h...s...t......s.......G.....p.....s...l...s...l..p.p.t......................sshp.slt-l...............cuhplu.h..s.h.....s..u..s.p.p.h..h..l..p..h..h.L....t.p..s..Glss............................pDl..p.l.h..h.h.sP...s.ph.......s.s..u.h...p...s..G..p...l..D..u...h.s..s...........h.-..P..a...s....s...ts......t......p..s..h..u......phlh............ss..t.p.l......................h.s.sh.........s..t..ps...........hhs.pp....p....a.h..c..p...p..P...p..s.s..ps...h...lp...u.hhc...Atpa.....hp...t...t.....t....ttt.....................................................................................................................................................................	0	383	868	1164
+13222	PF13380	CoA_binding_2		CoA binding domain	Coggill P	pcc	Jackhmmer:B0SEN3	Domain	This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.45	0.71	-3.92	341	4531	2012-10-10 17:06:42	2010-09-23 16:03:17	1	30	2872	8	1431	4521	2487	121.00	29	26.68	CHANGED	+s.........lAVlGhS..s.pss+...suht.lhphLt.t.......pG.hplh.....PVsPp........pplhG.t.......t.....sassLs...t.s........tslD.....................hVslapssptsssllcch.hsh........s....scslWhQ.G...........shspcstphAcp......s.Glp.ll..spChtltts	.............................................................................+olAVlGAS..s..c..ss+.......s..u.ht....lh+.Lhp...........pG.....p...lh......P..V...sPph...................................ppl..h..G...............p................sYsols.........p..........PtslD......................lsslhpsu.c.ts.sllc-h..hpt.....G........s+.s.hh.l...u...................hhp.c.c.h.t.t.hAcc............t.G.hp...llh..s.pCltl...s.............................................	0	459	926	1215
+13224	PF13382	Adenine_deam_C		Adenine deaminase C-terminal domain	Bateman A	agb	Jackhmmer:C0A9T6	Family	This family represents a C-terminal region of the adenine deaminase enzyme.	27.00	27.00	27.50	27.40	26.40	26.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.68	0.71	-5.10	110	1480	2010-09-23 16:28:37	2010-09-23 17:28:37	1	12	1271	6	346	1189	171	167.40	36	29.18	CHANGED	spl.lTcchhhpl......pl.p...sGhh..ss..ppD..l.hKlAVlERapt.s.GslulGhlcGaGl+.pGAlAoolAHDSHNllVlGssDcDMhhAlsplhchtGGhsls........psGc.llupLsLPlAGLMSs.pshcpVscplpplpp.shc.p.lG.s.s.h.p...sPFhoLSF.LuLsVIPcLKlTDpGLhDVppaph	.........................s..h.Tp.h..ph....h..t....ss.h......s...p.p.D..l.shlAVlE.Raup.p....tsh.uhGllpGF....G..l.p..p.G.A.lAoTluHDSHNIlVlGp..ss--MthAsNplhphGGGhslV........p.s.Gp...Vhup..lsLPIAGLMSs.pshpp.lsc.plctLcp.Ahc.c..h..G...st....hs....cPFhphuF.LuLsVIPtLKlTspGLhDspphp...................	0	136	260	294
+13225	PF13383	Methyltransf_22		Methyltransferase domain	Coggill P	pcc	manual	Family	This family appears to be a methyltransferase domain.	21.90	21.90	22.10	21.90	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.90	0.70	-4.84	9	252	2012-10-10 17:06:42	2010-09-23 17:52:57	1	11	100	0	209	288	84	207.40	20	68.36	CHANGED	u.AsKcu.uFFDchhsshhpthpc+hh.Fpphspst.................ppcsttWY.-NlEPshTC...sp.pRlGs..tG.........-GsKWlCDPpRLhp..........pts-CLlYSlGSsscasFE-ulhc.lups.CEIHVFD...tshsps.ssp.pthaap.hGluuuh-.shss................hhsht-h..tLsH.htRTIDlhKIDCEtCEWusYtsWhssDs...cphLlElHu..............................Psppss...........spcFapthhcpsahhFpKEsNl.a...pptClEauaI+	...................................................................th.....................................................................................h........hhu......s.........................DGsp..h..lC.t.sp...t.h.........................................................pC.hlaSh..G.....h.s.sphsF..-tph.hp.hs...CclasaD......s.......t...p...t...t.......p....t.t......p.h..ha.....tph.........ulu....tt...s...s..p.....t...st.............................hsl.tslh.p..t.h...s....H.....t..p.h.l-lLKh.DlE......u....s.E...a....p....s..L.........p..s..h.l....p..p.th...................hpQlhhElH.h.............................................st..............................hh...p...t...htt.s..hhhat........................t................................................................	0	84	110	190
+13226	PF13384	HTH_23		Homeodomain-like domain	Bateman A	agb	Jackhmmer:C0A3L3	Domain	\N	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.52	0.72	-4.18	345	2487	2012-10-04 14:01:12	2010-09-24 17:38:01	1	100	1542	3	717	11862	1498	45.90	20	22.10	CHANGED	stpttpRhp..hlthht...p........uhshpplAphl.s.loppolt.ch..hppa..........p.pG....hpulh	......................................t......h.t...hhhhht......p...........Gho.hppIActl..G.lo.csT.Vt.+h...hpp.........................t.................................	0	199	482	617
+13227	PF13385	Laminin_G_3		Concanavalin A-like lectin/glucanases superfamily	Bateman A	agb	Jackhmmer:C0A826	Domain	This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.36	0.71	-3.99	726	6160	2012-10-02 19:29:29	2010-09-27 13:17:45	1	933	1411	34	2404	8060	5104	168.50	14	16.23	CHANGED	p.u......h.h..h....sus........ss...h...lp..........h...ss......ts.................h.....s....ss.......sh........................T..lssWl..p.hs........s.....h.s......st..tth.....hh......................................s....ss..s.................sht.l...t.....................h.......s....ss.s............ph.t..h...........th...tss....s................................t.t.........php.....s.ss...........sh.s..................s....s.pW.pHlsh.s..hs.............u..s...................s.......hp....lY.l.......s...Gp........hhs...s..........t...s..t..sss........................................................................hs..............s..ss....h...................h....lG.........................ss.t................s.....s............spha.s.......G.....t.....l.D-lplas......p.uLoss-lp	..................................................................................................................................................................t..................t......h.........h....s........................h......s....sp.......sa..........................................T..lss.hl....p.hs......................s.....h.s.......st...tth....hh...........................................................t.sts.....................tht.l.t...................................................................h.........s...sss...............ph.th............thtss....t.................................................................................................thp.......s..ss..........sh.p...........................s.....sp.W.t.+..lsl.s..hs..............s..s......................................p........hp..lY..l.........s...Gp..........hhss........t...s..h..sss.........................................................................................................................ht........ts..ts..th...................h....lG.....................................................sst........................s.s.........tp.h..p.........G.....p.........l..spl.tl.as......p.sLsttpl..........................................................................................	0	1029	1475	2077
+13228	PF13386	DsbD_2		Cytochrome C biogenesis protein transmembrane region 	Coggill P, Eberhardt R	pcc	Jackhmmer:B0SI46	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.80	0.71	-11.67	0.71	-4.57	161	1138	2012-10-02 18:22:22	2010-09-27 14:35:20	1	9	1040	0	354	3522	1325	201.20	26	81.07	CHANGED	sshllGLh.Guh.HC...lGM..CGGlshuh.....sh.....st...........p.......p........p..t.....h...t.........h.lhYslGRlhoYsllGslhG.hlGs....sl..thh....st....h.....t..h....lph.hhu.lhhslhhlhhuhthh.h....h...h....hh..t........l....tp....ls.....ph.l...hphh....psh..tpph.........psh....hs.shhlGhlhG.hL...P.C..G...l..VYsslhhAh.so..G.ushpGulhMhsFGLGT...lPshlsh..uhhssh.l.........pt......hhp.......p.th.h.+..hs..ul..llll.h.Glh	.................................................................................h.hhllG.ll.uu....h..HC........hu.M....CGG.l.s....h.uh............shs............................................t..............p............p.h........h...h............h.lhYslGRl.....hoYsl.l.Ghl.h.G.hlGp....hl....s......st..............h....lph.hht...hlhslh.hl.h..h.u..hhhh..............t....hh..h...............................l........tp........h..s.........th....l...h..p...hl......p.l.hpp..........................psh..h..sshhlG..h..l..h..G..hl......P..C....G........l....VY.s.h....l.h....h.......A.h.s.s........u........s........s...hp.G.uL.hM..h..sFGLG...T.....lPshlhh.....uh...h.u...ph..l..............sp.........hhp...........p..hh...h...+....lu..uh..lll.h.hGl....................................................	0	126	259	317
+13229	PF13387	DUF4105		Domain of unknown function (DUF4105)	Coggill P	pcc	Jackhmmer:B0SCN2	Family	This is a family of uncharacterised bacterial proteins. There is a highly conserved histidine residue and a well-conserved NCT motif.	22.20	22.20	22.20	26.90	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.22	0.71	-5.09	149	716	2010-09-27 13:47:27	2010-09-27 14:47:27	1	1	544	0	199	698	188	171.80	22	36.56	CHANGED	ss......tttpahp...........thtssplphs.hhsu.hhspshshaGHohl+h..............hpsthh.......thshsaus.sh....sshshhh+uhhGpa.phhhshtshpchltpYsphct...RslaphpL.s.Ls.pptptlhtplhctt.shp.t.....htYpahpsNCoTplhchl.ctsh...sttlth......ph....hh.sh.............shhchltph	................................t.......phs.cplphl.hhhu.httpsh..shaGHThl+h................thtD.pp......thshsaushst.......sp..hhhcGhhGpa..hthss.hshpchltpY.sphct...Rslaphp.L.s.Lo.pctptLhtphhcht.phs.......hhY.ahssNCsoplhchl.ctsh...ss.l.hs....ph....hhss.............thhphl.p........................	0	69	127	171
+13230	PF13388	DUF4106		Protein of unknown function (DUF4106)	Bateman A	agb	Pfam-B_5 (Rel 25.0)	Family	This family of proteins are found in large numbers in the Trichomonas vaginalis proteome.  The function of this protein is unknown.	27.00	27.00	27.60	32.80	25.20	26.80	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.54	0.70	-5.51	13	401	2010-09-27 14:06:47	2010-09-27 15:06:47	1	5	1	0	401	401	0	270.60	73	66.03	CHANGED	MQKAMKSAEYIKANNDWLDAQANAKAAQLIGSIRTKIQADEDSSNEALTNADFKNAFEALHSKVK.VNDFSSGKKLKSEGFDKEL+EVAQNMTKITDAATRQAVQSAYDAVRATVVESQEKELQQTKTDLVNAFL+TKSQVGHYAADGTYVPAGGTYIPAGGTYILASGTYIPPNPPREAPAPGLPKTFTSSHGHRHRHAPK....PTQQPTVQNPA...........QPTVQNPA.Q...............QQPsQQPssQ..............PAQQPssQpPA..........QQP..QTEQGHKRSREQGNQEFLKMLKE-YGYPDTlDFSDRYKEAIRKFKEGNTDPNLFSFMAQHQIGYNLKPGKYKLAKGYDLIAYHPNDMsEFTPRYLMSELNDNSTlFMKRVKNRDGTKEERhMssDDLsRELVKNGLGIYEMPA.......DEVQETPQEE.VQIQPDMEEIVQQQQLEEP	..........................................................................................................MTKITDAATRQAVQSAYDAVRATVVcSQEKELQQTKTDLVNAFL+TKSQVGHYAADGTYVPAG.......GTY........I...................................PPNPPREAPAPGLPKTFTS....SHGHRHRHAPK........PsQ.......Q..PT...Q....ss............pPs.Qpss.t...........................s....Q.ss.p............sA......Q...P..osQ..ssA..........Q.QP....QTEQGHKRSREpGNQ-FLKMLKEsYGYPDTlDFSDRYKEAIRKFKEGNTDPNLFSFMsQHQhGYNhKPGKYKLAKGYDLIAYHPNDMsEFTPRYLhSElND..NSTlFMKRVKNRDGTKEERhMssDDLsRELhKNGLGIYEMPs.......DEVQET.Q.....EE......VQIQPDMEEIVQQQQLE..............................	0	401	401	401
+13231	PF13389	DUF4107		Protein of unknown function (DUF4107)	Bateman A	agb	Pfam-B_5 (Rel 25.0)	Family	This family of putative proteins are found in Trichomonas vaginalis in large numbers.\	 The function of this protein is unknown.	27.00	27.00	37.00	35.00	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.88	0.71	-4.54	4	582	2010-09-27 14:17:08	2010-09-27 15:17:08	1	2	1	0	582	582	0	140.50	87	90.96	CHANGED	MGTKALAFGAKALGAYDAVNKMSGGRVSKTLDANKGKIGGWVAKKLRLNKIGLINKASNLVATESENALGKDDEFAKHAKDFNDQMKGETMHLNRVDGTKENVSSPPAVhPYGPYGMYGNPYERPFDPLTGGSNWYHYGRRRKTVKLETDVKKATKKK	..................................MGTKALAFGAKALGAYDAVNKMSGGRVSKTLDANKGKIGGWVAKKLRLNKIGLINKASNLVATESENALGKDDEFAKHAKDFNDQMKGETMHLNRVDGTK....ENV..SS...P......P.....V..............VL.P..............Y......GP.....YG...M.....Y.G.NP.....YERPFDPLTGGSNWYHYGRRRKTVKLETDVKK.ATKKK.........................	0	582	582	582
+13232	PF13390	DUF4108		Protein of unknown function (DUF4108)	Bateman A	agb	Pfam-B_8 (Rel 25.0)	Family	This family of putative proteins are found in Trichomonas vaginalis in large numbers.\	 The function of this protein is unknown.	27.00	27.00	132.80	132.50	20.90	19.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.98	0.71	-4.44	38	686	2010-09-27 14:18:04	2010-09-27 15:18:04	1	1	1	0	686	686	0	131.20	85	97.24	CHANGED	TKFISVNKYMotlKEELDPFsYLNVYFYHFEKS.oFcKVWNIEPVKFAIVTK..NGApFEDL..DIEGLLsVKENFDR+FSpLcEGKAYKLVIPYEPKKADDYEYYESKIVEVQGKLGKKILESK.....PVFAPKEEENIDIDPE	............................sKaISVNKYMotlKEELDPF....sYLNVYFYHFEKS.oFsKVWNI.EPVKFAIVTK..NGAKFEDL..DIEGLLsVKEsFDRRFSNLKEGKAYKLVIPYEPKKADDYEYYESKIVEVQGKLGKKILESK.....PVFAPKEEENIDIDPE......................	0	686	686	686
+13233	PF13391	HNH_2		HNH endonuclease	Bateman A	agb	Pfam-B_14 (Rel 25.0)	Domain	\N	25.00	25.00	25.00	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.40	0.72	-4.19	198	1540	2012-10-05 18:28:12	2010-09-27 15:37:21	1	23	921	0	616	1405	179	64.70	29	19.80	CHANGED	Csl..oGhph................................lcAuHIh.Phu.........................h...tsp.....................................................sspNGlhLsssh..HphFDpthlsls	.....................................CsloGhp.......................................hlcAAHIhPhp.........................t.s....sss...............................................................sspNGLhLssph..HphFDpuhlulp....................	0	118	339	479
+13234	PF13392	HNH_3		HNH endonuclease	Bateman A	agb	Jackhmmer:Q7P8C3	Domain	This is a zinc-binding loop of Fold group 7 [1] as found in endo-deoxy-ribonucleases and HNH nucleases.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.11	0.72	-4.56	226	1385	2012-10-05 18:28:12	2010-09-27 15:51:52	1	43	897	1	251	1201	508	45.20	27	24.40	CHANGED	hhhHRllaphh....hG....thP..s.s.h.........hlcHhs.s.s+....pssph..sNLchsoppcNtt	....................................hhHRllhtth.........hs........shs..p.s.h..........plsHls...s.s+.......tsN...ch.....sNLchsopppN...................	0	83	160	209
+13235	PF13393	tRNA-synt_His		Histidyl-tRNA synthetase	Coggill P	pcc	Jackhmmer:B0SA16	Family	This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.92	0.70	-5.37	129	7540	2012-10-02 14:22:40	2010-09-27 16:44:42	1	40	5007	33	2112	6233	5624	291.80	27	66.39	CHANGED	GlcDlLPtcApph-pl+cpLl-happaGY-hVhPPhlEah..-oLlsGs.....ut.s..h.c......p.saKl.sD.p.oGRhlGlRuDhTsQlARlsAp.p.l....s..pp......tstRLCYsGsVl..+spsst..h......t..ss..REslQlGAELaGps.ulpA.DhEllpLhlcsL....t....sG.l...pplplDLuHsslhcsl.h.p.sss..lststpptlhstLppKshsplp.plst...t.....hs............tsh.t.phLttL....pLtGshcsLp..cAtph.lss.h...s.t..htt.slspLcpltshhpsh.....t.splplDLu-lRGacYaoGlsFssYs.....sG..hu..p..slApGGRYDplstt.F.....G..+..........sc.......PAsGFSl-lctL	.......................................................................................................GhpDhlPtp.hhh..ph....lppthpphh.p.paGappl.cs.PlhE.....h.clh..tp.th.................G-..s...s.c.............c..h..Y..p...........h...........................D......c.....s...............s...........c...............p..............l.......................s.LRs.-.h.Ts.s.h.s..R..hh.hp..p...h..........hs...................tsh+haY.hGshF.Rh.-.+.s..p...t..................G.....Rh..R..pFhQhG...h.E..........hh......G........s.....s..s...t....h......D.u.E..ll..t...hshchhp......t.....LG..l..................pp.h..p.l.clN..shs.h....h.c..........................h....p........t........t....h....p.....p........s....l....h......p...h...l.....p.............p.......h.....p.......h.....t.....t......l.......c.....c.h...h.p....c...........t.....lp..................................................................pp.....h....ch.Lps.h..........ph.p....s...s........t........p.........t.......l.t...........p.s.....h...t...h....l.....s...t...........................p..p.........u.....h....p.c.........h.ptltphLc......sh..............t.hth.p.l-.....s.l....l..R.G....L..D...Y....Y.o....t......slFE..h.......h..s.........................s....s.......hs....s..................slsuGG.....RYDsLlpth....tG...p......................sh.............PulGFuhGl-Rl...............................................................................................	0	694	1329	1754
+13236	PF13394	Fer4_14		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:B0SHY7	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-11.08	0.71	-4.08	151	9987	2012-10-03 08:56:43	2010-09-27 16:54:42	1	73	4097	8	2936	16021	4178	110.20	19	33.66	CHANGED	lFl..uGCsh...........pCp................sC......sttthcF................ssGc.hstphhspll.............hpssth..ttlsloG.GEPhh.hspt.hh.Llcpl+ppt.......hcIa.l.Tshohp...........th..t..hlu......hh-.llscGc	.................................................................h.......tsCs..l.........................pCp..........................................................aC.h...............s.t..t...t..h.sh........................................................................t.t.t..p..h...h...s...h..c..p...l..h..p..h.lt.............................h.tt..t.s.h.......p...p..l.s.lo..G....G.E....Ph..h..........p........t.......l...h....t...l.l.....c...t....l...p...p.ts..................hp.l..p....l..p..T.s.G.h.h...........................................hhttthh...............................................................	0	1066	2000	2532
+13237	PF13395	HNH_4		HNH endonuclease	Bateman A	agb	Jackhmmer:Q7P7J1	Domain	This HNH nuclease domain is found in CRISPR-related proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.68	0.72	-4.33	93	798	2012-10-05 18:28:12	2010-09-28 10:39:15	1	12	747	0	166	2662	2689	53.20	33	6.29	CHANGED	shYoGctIslscLhs..tta-IDHIlPhS.hhhD........DS.hsN+VLstpphNpp...Kusc.sPh	........................shYoG.c...t..l...s..hp.pl.t..........h-IDHllPhS...h..h..hD...................Do..htNhVLsppptNpp....KusphP.......................	0	59	115	147
+13238	PF13396	PLDc_N		Phospholipase_D-nuclease N-terminal	Coggill P	pcc	Jackhmmer:B0SFY4	Domain	This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, Pfam:PF00614. However, a large number of members are full-length within this family.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.33	0.72	-4.29	441	4348	2010-09-28 09:45:17	2010-09-28 10:45:17	1	24	2893	0	835	2871	257	46.90	27	12.42	CHANGED	hhllslhs.llpll.tp......p....tss......ss+hsWlllllh...lP..llGsllY.llhGcp	.........................h.hll.lhs.h.lpll.hp.............c.....+ss.........ssphuWllllhh....lP..llG..hllY.lhhGp.........	0	273	568	736
+13239	PF13397	DUF4109		Domain of unknown function (DUF4109)	Coggill P	pcc	Jakhmmer:C7MCW6	Family	This is a family of bacterial proteins with several highly conserved characteristic sequence motifs, such as: APR, WxC and ERR. The function is not known.	25.00	25.00	58.90	58.50	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.57	0.72	-3.65	79	618	2010-09-28 12:50:06	2010-09-28 13:50:06	1	1	430	0	167	347	96	101.60	49	89.31	CHANGED	RuLRGoRlG......usShEo-+ss-hAPRpplpYhCss.GHphplsFAs...-AEl..PssW-C+.CGt.Aths..cus..sP-sp.tsKPsRTHWDMLhERRS.pELEplLpERLphLR	....RsLRG.plG......uhShEs-Rss-hAPRphlpYhCsN.GHchclsFAs...-A..El..PssW-C..CGh...Aths..cus....sPp..sc..sKP.....RTHWDMLhERRS.tELEtlLsERL-hLR.	0	60	130	159
+13240	PF13398	Peptidase_M50B		Peptidase M50B-like	Coggill P	pcc	Jackhmmer:C7M9M6	Family	This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.44	0.71	-4.93	100	639	2012-10-03 04:41:15	2010-09-28 13:50:45	1	11	589	0	249	815	96	197.80	26	80.07	CHANGED	ll..sh.llA.lhllh.s.....h....lht..........h........+hls....ohhHEhGHAlsAlLoGtclpuIpLpsD........pSGlsho..pG........tGhuhhlsshAGYhusulhGhshhh.hs..t.s..sps...sh...hL.h...lsl.s.l.Llsh.L.lhh.Rshhul...hhlls...huslhhslhhh...sss...ph....s.....hh...shh.....lulhlhl.uult.s....l...........h.-L........h......pt...t.st........pSDAstLAc.lTt............lP..uhhW..ssl.ahhl.ulssl.hhu	........................................hh..hhhsuhhlhhtt..........lhp....h........h........p.h.ls..............shhHEhGHslh....shLsGG.+sc.slhlhs..s.............................................pp..Ghslopu..............thh....u.h..........lo..shu...GYh..h..s.s.l......h.h....hh...h..lh...ss....th.....phs....sh.....hlh...hhl..h.l..hlhh...L.lhs...R.ph...sl.....lslhl......hsh..h..lh.hlhh.......tp........phhh.......hh.....shh.....hhlhlhLstlh.p...................l.........hcL......h...................pp.....ss........p.Du.......stLtc.lot.................lP..hhlashl.ahlhslhsl...h..............................................................................................................	0	91	170	223
+13241	PF13399	LytR_C		LytR cell envelope-related transcriptional attenuator	Coggill P	pcc	Jackhmmer:C7MGV9	Domain	This family appears at the C-terminus of members of the LytR_cpsA_psr, Pfam:PF03816, family	22.20	22.20	22.20	22.30	22.10	21.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.95	0.72	-3.61	203	1654	2010-09-28 13:27:52	2010-09-28 14:27:52	1	14	748	0	494	1394	193	91.50	23	24.14	CHANGED	sspls..V.pVhNuo.sh......sGLAuplustLps.p.GFs.s...sss..uNs....s......ss.....t.....spop.lh.a....usss.pss.A.t..s.lust..l....s...ss.p.lh.t.s....s...tts..s...s...lplll..Gs-aps	.......................tphpV.pVhNuo.sh........sGlAupsustLp.s...t.G...Fss...sss..uNt..s...........ss.....t.....spop.lha.....ssus....pss...A..p...plupt..l........s....ss..s...lt.t..s...........s.......tts....s............s....lplll..Gpsat..................................................	0	156	375	464
+13242	PF13400	Tad		Putative Flp pilus-assembly TadE/G-like	Coggill P	pcc	Jackhmmer:C7ME36	Domain	This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG [1,2].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.38	0.72	-3.93	284	1158	2012-10-01 21:13:59	2010-09-28 16:26:36	1	8	766	0	467	1471	102	51.90	26	14.21	CHANGED	G...sss...lhs..lhhlsllh....hhuhsl.D..huphhhs+sclQsu...uDsAALA..u...........A...ts	......Gshs..lhu.lhhlsllh..hsuhul.Dhuphhhs.+sclQsA...ADsAALA.u......A....................................	0	144	280	372
+13243	PF13401	AAA_22		AAA domain	Bateman A	agb	Jackhmmer:C0A2E2	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.90	0.71	-4.01	168	4268	2012-10-05 12:31:09	2010-09-29 11:23:30	1	160	2155	9	1502	14349	3197	134.70	17	27.70	CHANGED	hp........ppshh......hlhGpsGsGKThshpphhpth.................................pspsl...hlpsssss.......ohppl.hpplhptlshthtt..........................sttphh.ptltptlppptt..................llllDEApp.L....s.....tphLchl..ptl........hs...........ppslsllLhGps.plpphl	.....................................................tt...tthhhlsGpsGsGKTsh..h....pp...hhp.ph.................................................................phphh..........hlp..ssstt...........ssppl...hp.....t...lh....p..p.l.s...h.thss.........................................................................................sttphh.....ptl...t..p...h...lppppt...................................................hllllD...E.scp..L.........s.................tphL.ptL........ch.l...hs..........................pt.h.t.l..l..lh..G........................................................................................................................................................................	0	443	929	1274
+13244	PF13402	M60-like		Peptidase M60-like family	Nakjang S, Hirt RP, Bateman A, Eberhardt R	agb	Nakjang S, Hirt RP,	Domain	This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity [1].	27.00	27.00	27.50	27.40	26.30	26.90	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.71	0.70	-5.52	67	818	2012-10-03 04:41:15	2010-09-30 13:21:49	1	49	547	1	178	859	44	289.90	27	25.67	CHANGED	sshp.sTGlYsssscplslpl.....tsspslplhlusp..scp...........tp.shhtppas....Lssupsplps.shGGllYlh.....ssstst.....slplplsu.uh.sPhahhGppop.p-Wpp.lpphs.uPhsElpscphllTs.sscsl+ph.....sDsptlhchaDchhptts.-lsGhscp..t..pt............+hVsclphs.huhha.uGYslhhsss....shppllsh.stht..ssWG.hHElGHstQps.sapas...u.ssEVTsNlaolhspcthh..sp.tpthp...........tsch.....ppshpalppspsphth................tshhhtLshahQLphhaG	.............................................................................................................................................s.shp.sTGlaA.stpplslph.....tssss......s..slpl.tlu...sc.hs.cchtp........th.tRs.sh..s..s.c.p.as..............Lp.s.s....p.s.phps..s.............aGGLlYlh.............sspsst...........ssphoh...su...ssp.....sPa...a........t.........pp......tc.......Wpp...hhps...................s...u.................P.......h.......sELpo-shlhTs.s...p...cs...lps.......................ss...s......p........ph.......h...cp...h.D..p....h...hps.h...s.c........h.hGhsp......t.s.sppp.hp........................+ass-lplu...huhha.o.GY.slhsssh.........s.s.p.sl......s.......h...ps.......l............s............sWh...hHElGHNtp....ps..shphs...............u..sTEVssNlhuLahpc.phh........sphpp.................htsch...phu..p.alp.p.s.sspt.h.....................sshspLhhahQLp.hht....................................................................	0	67	89	126
+13245	PF13403	Hint_2		Hint domain	Bateman A	agb	Jackhmmer:A3PK18	Domain	This domain is found in inteins.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.27	194	984	2012-10-03 10:25:13	2010-10-01 10:01:36	1	80	208	0	187	918	160	135.40	32	24.73	CHANGED	sCFssGThItTspG..hsVEsLpsGDhVhTtD.....sG...hpPlpWlGp.pp..l........h.sstsph..t.Pl+Ip..sGALGss.....hPp+DLhVSPpHRlLlss...sphhhuptcVLlsAcpL..........l..s...t.ss..l.p...tt......s...s.p....t.VsYaHlhh-pHcll.hApGs.sESahsGs	....................CFhsGThIpTs.pG.....hsVEsLpsGDhVh..Th.-............su......h..p...s..l..pWlG.p.p.p..h........th.ssst.sh..hP.lRIt..t.s.A.luss..........hPtcDllloPpHplhlp..............th.hlsA+tL..........Vs....u..tu..I.h....pp......s....hs..shsYaHl.h-..pHpll.hA-.Gh.sESahss.s....................................................................................	0	22	148	169
+13246	PF13404	HTH_AsnC-type		AsnC-type helix-turn-helix domain	Bateman A	agb	Jackhmmer:A3PS88	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.22	0.72	-7.78	0.72	-4.42	347	5527	2012-10-04 14:01:12	2010-10-01 11:47:45	1	33	2295	47	1669	9314	1799	42.00	35	25.97	CHANGED	l.DclDpcILphLppc...uRhohpcluc..plGLSsssstcRlc+Lc	.........lDclD+pILphLpp-....uR.h.s.h.s.cLAc..plG.....lSsssltpRlc+Lc..................	0	419	1008	1383
+13247	PF13405	EF-hand_6	EF_hand_4;	EF-hand domain	Bateman A	agb	Jackhmmer:A3PLV3	Domain	\N	25.00	14.90	25.00	14.90	24.90	14.80	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.69	0.74	-7.96	0.74	-3.58	793	5737	2012-10-02 16:17:27	2010-10-01 13:55:03	1	526	696	127	3421	36588	2275	32.40	24	8.28	CHANGED	plp..phFphh.D.ps...psG..hls.h.p-l.pp....hlp..............t.hu	.................hp.psFpha.D.p-........tsG......tls.h.pEl.pp....hhp................................................	0	1356	1922	2697
+13248	PF13406	SLT_2		Transglycosylase SLT domain	Bateman A	agb	Jackhmmer:A3PHY1	Domain	This family is related to the SLT domain Pfam:PF01464.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null --hand HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.63	0.70	-5.48	176	3080	2012-10-03 00:09:25	2010-10-01 15:54:35	1	19	1866	9	798	2548	2044	255.30	32	69.52	CHANGED	sapshltsh.pppAtppGlspsslpps....hsss.php...........tpllcht.......ppQs....Ehs.p..s......htcYhsth.ls.spRlppGpphh.ppatshLsclEpcYGVssplllAlWGlETsaGp.hhG..s....hsllcuLATLAa.-..t...........................RRssaF....cpELhssLpllccsp.lss.................pp.hpGSaAGAhGpsQFhPooahpYAV...DhDGDG+tDlass..ssDAluSsANYL.ppp.GWpsG.pshuhplpls..............tshsh.ht...s...hpsh............spht.thGlp.hsst..........s.......thts..pL...tutpG.........ss..aLshpNF.hlIt+YNpSshYAhuVutLA-	................................................................................................s..t..h.tth.pt.stttGhsttthpth..h...sts..ph...................tllph.........................ppQs.........thp..........s.............hhpYhpph...ls...tpl.pp..Ghthh.ppatshLp.chtppYGVssphllulhGlEotaGp...hhG..p....hpl.l....suLuTLua.s.h.............................RRtpaF....ptcLhshLhhhp.pt.p.hs.s...................p..h.pG..S..aAG...AhG.sQF............hPooatpYAV...DhcGDG+h..Dlass..ssDAluSsANYL.....ppp....G..WppG.tshuh.sp.h........tshp......t......h....h...........................................................s....tst..u.lhh.tsttG............t...ahsh.NF..slhcaNp.....S.hYAhulh.Lu............................................................................................	0	186	454	620
+13249	PF13407	Peripla_BP_4		Periplasmic binding protein domain	Bateman A	agb	Jackhmmer:A3PPI0	Family	This domain is found in a variety of bacterial periplasmic binding proteins.	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.69	0.70	-5.03	173	12924	2012-10-02 13:57:41	2010-10-01 18:32:26	1	44	2863	86	3019	24092	3112	255.70	20	75.86	CHANGED	lu.....lsh..stsss.ahpt....htpuhpptspp.hshphhh............ts..upsss.spQhp.lpsh.lsps........sc..ull..lssscs..suls.sslcp.ApstGI.s.Vls........aDss...........ssstphh..........hluh-stph...Gphtu................................chlscthssp............uplsll....sGsss.ssstp...tt....hpGh.pps.....lpp..................hs.plplhs...............................s.s.hssspuppt.hpslLs...ss.........l........sul.hu..sssshsh...........u....shpulpp.tuh..tsp..h...........lsGhDssstth.phl.............psGphp..s...slhpssh...th..uttuhphsh.ph..hp......Gcp	...............................................................................................................................................sh.h..thsss..ahst......hppu...h....p.p....t...u....c....p...huh.phhh.....................supsc....sp..Q....h..p.t...l.csh..l..s.ps............sc.....u.l.l........l..s.....s...s....c.s.........s.u..h...s.....s.....s..l...c...c.....A...p.........p.....t....s.....I....s...V.l.s........................hDpt...............hsp.s.t.h.s.s......................hl...u...s...D...s...h...p..s....G..ph..tu.........................................................................................c.hl.s..c.phstp...............................................uplshl....................t.G..ps..s...s....s.s.sp............tR.............tpG.h...tps...............lpp....................................s...sh.c.lls......................................................p......ss.s...h.s..t...s..p.u....h...ph....h...p.sh.Lp.................sp.s..............pl.......................................................s.ul..hu..ts..Dshuh....................G.........Al.p.A...lc...s...tuh.......ssp.hh................ls.Gh.D...u...s...s...p...s...h...pt.l.........................p.s..G.p..hs............s......o.lh.p.sst....th.u.t.h.uhp.hsh.ph...hp..s............................................................................................................................................................	0	815	1763	2389
+13250	PF13408	Zn_ribbon_recom		Recombinase zinc beta ribbon domain	Bateman A	agb	Jackhmmer:A3PQ69	Domain	This short bacterial protein contains a zinc ribbon domain that is likely to be DNA-binding. This domain is found in site specific recombinase proteins. This family appears most closely related to Pfam:PF04606.	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.33	0.72	-3.71	726	3758	2012-10-03 10:42:43	2010-10-01 18:35:27	1	37	1459	0	677	3269	314	62.10	23	12.28	CHANGED	hL..s..G..l..lhCup.......CG....p...s.......h.....tt..........p.....p....pp........tpt.....................hh..Y....tC.s....st...h..pt.t...................p.....Css..p......plpt.ptl-...phl...hpt...lp	...............hsG..l..lhCup........CG......s.s.......h..tt..........p....p.....pp............ppp...................th..Y..tCs....pt.....t..pts........................p...Cstp......plpt.chl-...phlhptl........................................................	0	325	545	625
+13251	PF13409	GST_N_2		Glutathione S-transferase, N-terminal domain	Bateman A	agb	Jackhmmer:A3PFR8	Domain	This family is closely related to Pfam:PF02798.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.50	0.72	-3.98	315	3673	2012-10-03 14:45:55	2010-10-04 11:15:34	1	29	1984	30	1074	16648	5196	85.80	29	29.54	CHANGED	hs.Pas..p+shlh.Lpht.....ul...s.hp.....h..p.h................l............t.h..................p...th.......................................................h.p.hs......P..t..s..................................................p.....lPsLhh.............................t...sup.............sls..-S....tsIhc.aL.ppt	......................................................sPhu..p+shIh..hc.h...........GL.....-...h.....l..sh.................s.........hh..htps.....................ph..u.ss.F....................................................................................................s.c.hs......s..p..s...................................................p....VPsLhD...................................c...psp...............llss...ES.up.Ilphlsp....................................................................	0	300	612	885
+13252	PF13410	GST_C_2		Glutathione S-transferase, C-terminal domain	Bateman A	agb	Jackhmmer:A3PFR8	Domain	This domain is closely related to Pfam:PF00043.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.27	0.72	-4.08	279	7419	2012-10-03 01:14:49	2010-10-04 11:42:28	1	51	2398	100	2549	11894	3037	85.10	19	31.76	CHANGED	pth..hpp................................................h.htp.....ltpsls..tl........cp.p.hs.......................................pt.............hh.Gs.......phohuD..hsl.h...s....hl...t.h.h......phh.....hh...t.h.......................thh.......p....t.h..spltsah.cp	...............................................................................................................tt................................hhtp.....hhptLs....hL.........-p.t..Lu.............................................................................................ppt............als.Gc.....phohAD......htl..h...s.........hl.....h.p...h........phs........hh...t.h................................hh........t.......s.h....spl.tahp.t........................................................	0	615	1327	1986
+13253	PF13411	MerR_1		MerR HTH family regulatory protein	Coggill P	pcc	Jackhmmer:C2D3E8	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.89	0.72	-4.20	214	18606	2012-10-04 14:01:12	2010-10-04 13:16:52	1	99	4180	5	3931	16622	3391	68.70	27	35.72	CHANGED	hsls-luchhsl........stpslRaaccchh...ltssc....pspsh.+hYsppclpplphIppLhp.pGholptlpchlptt	..............................hpIu-luch.s..u..l..................osco...LRaY.....-.c..pGL.....lp.Ptc..........spsGh...RhY......s.p...p-lppL.phIpphpp..hGh.sl.p.p.lpphlt..h......................................	0	1233	2583	3343
+13254	PF13412	HTH_24		Winged helix-turn-helix DNA-binding	Coggill P	pcc	Jackhmmer:B0SAM5	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-7.77	0.72	-4.57	608	12234	2012-10-04 14:01:12	2010-10-04 13:54:13	1	121	3550	54	3360	26657	3880	46.50	30	21.83	CHANGED	hDphDhcIL.phLpc..su+.lotp-LAcplu..lSsssstpRl++LccpGlIp	........................hsph-hpIL..ph.Lpc........suc..l..otp...-L....Acplu......LSsssstcRl+cLccpGlIp................	0	820	1884	2697
+13255	PF13413	HTH_25		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q87B38	Domain	This domain is a helix-turn-helix domain that probably binds to DNA.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.74	0.72	-4.33	195	2987	2012-10-04 14:01:12	2010-10-04 14:51:59	1	16	2861	3	621	3650	1038	61.70	32	21.10	CHANGED	hL+psRpppulolcclupph+lphphlpAlEpschs.tLP....ss....sas+Gal+sYAchLG.L..Ds...p...tl	........L+puRcphGlSlpplspchplphphlpulEpscas..tlP....us....sasRGalRpYAchlsl.-spp............................................	0	195	382	519
+13256	PF13414	TPR_11		TPR repeat	Coggill P	pcc	Jackhmmer:B0SDR7	Repeat	\N	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.52	0.72	-4.33	458	62040	2012-10-11 20:01:03	2010-10-04 16:34:37	1	8099	4563	105	30435	78055	23252	67.00	19	21.46	CHANGED	p.p...u..t..t..h.pphGpt.hh.p....p.t..c..hppAlptappu.l...p...h......s.......s.s...s....sp..........ha.hs..h...uts.hh..ph....s......p..p..hp....p.A....hpt..h..p.p.u....l.p......l.s..s	...................................................h.hth.G.h..hh..p...................t...s.......c.......a...p.p.A..l....p...t....a...p.c......A..l..................p.............l................s...................................P..p.......p........sp...............................................sa..hs.........h.........uhs..h.h.......p.h........................s..............................p....hp..............p.A..........hpt..h..p.p.A..l.p.ht...............................................	0	11553	19108	25290
+13257	PF13415	Kelch_3		Galactose oxidase, central domain	Coggill P	pcc	Jackhmmer:B0SIN7	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.56	0.72	-3.69	122	3739	2012-10-05 17:30:43	2010-10-04 16:49:49	1	745	564	0	2451	13422	417	52.60	26	10.03	CHANGED	ss..tlhlhGG..hs.........t..tpth....ssh.h..hh....sh....sss........pap......ph........ss...h....ss.....sRtsassshh	..........................................splhlFGG......hs.......................t....tphh....................sDl..a....hh.......cl...........sst.......................................pWp.............pl..........................tus........h...........Ps...........sRssHsssh.h..............................	0	922	1445	1978
+13258	PF13416	SBP_bac_8		Bacterial extracellular solute-binding protein	Bateman A	agb	Jackhmmer:A3PHX7	Family	This family includes bacterial extracellular solute-binding proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.25	0.70	-4.67	141	17239	2012-10-03 15:33:52	2010-10-04 17:51:20	1	26	3652	65	4107	24014	7960	298.20	16	73.07	CHANGED	phscpa.p....c.....p....s..s.......l.p..lp.htp..h..ss..s.-..h..spl...pst....ht..s...s..s..h..ss...h...sl...hhhs.sst..h.tphsp....ps...hlh........-l..s.............ph...t.phsp.........................................h..ss......hhpsh.......sh..cu.........hu..hP.hshs.s.sh..s................hhYspshh.........p.c...............s...........ss...poh.s.......sl......h.......c.....hp.......t..h................t......Gp.h..........................sh............h........p....s...s.....h.s.......hh...........hh.t.hhs........................sGt.t.h..sps.........stsh.......................sps.hphh.pp...ht....s..p..h.....h........hh................s.s..s...s...s..shs..ths......sG..c..sshhh......s....us....hs...hs...s.hp..................pt..s........t......s.hs.....h.........s......h.........s................p...........p.......u..........s.hh.....ss.p...s......hs..l....st....s...ss.pp...ph...tuhcF.l..pah.s.s.s-.spt....p....hhp....ttuh..h.P.sppss..t..t......sst....hp.......ps......st..h.s	..........................................................................................................................hhppF.p....c......p.s...s..........l.c..V..p...hph.......h....st......s...p...............h..h.....t..pl.........pst...............h.t....s..........G...s.......s....s.s......h.....s..l............hh.s.s.....s.s.h.......h....s..p...hhp..................ps.....hlt.......sl.s.............ph...s..phpp......................................................l..ss..........hhp.sh................sh...sG.p..............................hau........l..P.....h.....h..h.s....s..........h....s..............................................l.h..Y..N..p..c..h..h...................c.p....................................t..........................ss....p..o...W...s........-l..................h......p...........t.............ch.........................p..........sp.h......................................sh..............h.........s.....s.s.....p..t...........hh............th..h..hht............................................tGh.s.h..sps................sstph..................................tps..h.p..h..l...pp.......ht....s...p...h........t..........h.h...............................s..s..s.....s......p....h.....ts.......hh..t.............s...G.....c........s.s...h.sh............s..........hs.......hs....hs.....t.hp........................................pp...s.....h...........s..hs.......h...........s........h.........P................................................p.........p........u.............s.h.h.......ts..s....s........hs.....l.........s..p.......s.....up....sp........c.......Ahc.F.l........sal..h..s.s.....-...stt.........p......hsp........thuh...h..s..s.p.p..s.s.h....t..................................hh.............................................................................................................................................................................................	0	1273	2551	3313
+13259	PF13417	GST_N_3		Glutathione S-transferase, N-terminal domain	Coggill P	pcc	Jackhmmer:B0SCP7	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.38	0.72	-3.75	216	16191	2012-10-03 14:45:55	2010-10-05 09:52:41	1	91	2388	143	5495	19464	7212	77.70	24	34.58	CHANGED	La..s..h.t.SPas..p+lph.sLphps....l....s.....hc..h.....h......h..s.......sh.....p...p.......s..t..h........hth..s....shs...plPsL......h.p.s.....up.......slt....-S.t.sIh.ca.L...-pths.........ss..s	...................................................h...h..ss......hs......t..+....l..pl....s...L..pt...p...u............l........s...................ac...h........h...................tl....s...........................ht..........p....p............ss......p..h...........................hph..N...........P.ts..........p.VP.sL..........h..c..s.......st.............................slh.......ES..t...sI.hcY.L.scpas....t.....................................................	0	1291	2807	4225
+13260	PF13418	Kelch_4		Galactose oxidase, central domain	Coggill P	pcc	Jackhmmer:B0SIN9	Repeat	\N	21.60	19.00	21.60	19.00	21.50	18.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.49	0.72	-4.19	84	4909	2012-10-05 17:30:43	2010-10-06 13:08:44	1	961	757	2	3302	16453	618	51.00	22	10.48	CHANGED	sRhtts.ssh.h...ss..s..p.lhlhG.Gpsss.s........thhs-h.a..h..a....sh..ps..s..p..W........ppl.......s..sh..Ps	..................................RhsHo.ssh.l..........p......s..........p..lh.la....G..G....h...s..s..s..t.....................................ph..h...s...D...l...a.......h........a........ch.....ps........p........p.........W.........p.h....................t.............................	0	1424	2079	2760
+13261	PF13419	HAD_2		Haloacid dehalogenase-like hydrolase	Coggill P	pcc	Jackhmmer:B0SBQ3	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.05	0.71	-4.05	169	33740	2012-10-03 04:19:28	2010-10-06 14:29:26	1	189	4905	123	8845	29816	9459	180.80	18	75.44	CHANGED	llFDlssTL..h...s..hph........hhhpth.......p....p..........hh..hcph.......sh..s...........hp.tpp.....hcp.......h.......h.......thsh..t.....ph...................ltp.lh.....pph....s.hp..................st..ht....p.thpph.............th.....th..t...h.hss.ssp.hlppL.p...p...thpl.hlh.oss..s..t..tt.hp.t...hhpp..h....sh.....thac...tlh.su...p..p..ht.h..h...KPpsts.apthhpph.....sh.ss...pp....h....lhlsDsh.psl..ts.Ap.shGhps.l.hl	......................................................................................................................................................................llFDhDGT.L....h.......D.....st...................hh.h.ps.h..........p.p........................................h....h.pp.h...................sh.....p...................hs....pp............htp..................h..............h......................s.hs.h..t................ph.....................................................................hp..t...h...h......t.t.h.....s..hp......................................................htt..hp.....p....hh.tph....................................h.....pph......p......h..h..s...s.....s...h....c...hL.p...p...L...c..............tp.........s..h..p..l....s..l..s....oss...............s................p............ph...hp...t..............hl.p.p......h..............................slt........ph.F.......c............tl.h...su................p.....p........ht...t....t........................K.P.p.......P..c..h.......a....h......t......s....h.p.ph.....................sl...ss........pc.....................s..................lhl.s.Dsh.ssl..tu..Ap.su.Ghps.hh.......................................................................................	0	2568	5341	7324
+13262	PF13420	Acetyltransf_4		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:B0SAL8	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.84	0.71	-4.27	21	5238	2012-10-02 22:59:21	2010-10-06 17:18:10	1	36	2675	35	970	25638	3580	151.00	22	79.81	CHANGED	IRhlppcDht.tlhplh..pp...hhpt..th.s.....hth...sshphhc.chlpph.....p.....s..phhahlhc..sspllGhsplp..th...ch...pppps.lp.hhhh..tpspcpslspc...lhstlh.pah.cphslcplhssl.sss.......Nh....s........uhhFapphGFchhGh.+ssthhts.cahDhhW	.............................................................................................................lR.hp..tDh....t...t........l.....h.....t.....lh.........sp....h....h.........pp.......th...s................h..p.........................s...h...p.......p....h.....p.......p.....h......h.....c.....p...h.............p...................tp.........p.h....s...h.....h....V........t..........c...................s..........s..........p.........l....l.....G.....a..u...s.hs......sh..................cth...................shca.....s.....s.....E....h.........u......l......a.....lp........ssh...p..G..+..G..l.Gpp.........L.l.p.t.ll..ph...A..........c..........p......t.....s.......h....c...p.l.h..s..s.l...hsp................Np........s...............................ul.p.L.a....c.p....h....G.....F...p.h.h.G.t.h.p..p.s.t....h..h......s...p.ahD...h................................................................	0	272	584	802
+13263	PF13421	Band_7_1		SPFH domain-Band 7 family	Coggill P	pcc	Jackhmmer:C1ZGV5	Domain	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.13	0.70	-4.82	24	734	2012-10-01 22:02:33	2010-10-06 18:16:45	1	19	672	0	189	878	126	216.40	26	57.04	CHANGED	VWRF.RasNEIKhGApLsVREGQsAVFVpEGQlAD.VFsPGpYpLpTpNlPlLoTLpuWcaGFpSPFKuEVYFVNTppFssLK..........WGTpNPlhlRDPEFG.PVRlRAFGoYuhRV.sDPupFlpEIVGTDGpFTs-EIstpLRslIVpc....FuchlupotIPlLDhAANhs-Luchltptlssch.scYGLslschhlENISLPp...EVEcALDKRoSMGl	...................................................................................................t.p..IppGotlhVtpuQhslhV...pp....Gpl.h.D...s........h.p.sGh..Ys........lp..o.s..........s............h.............P..............h.........l..............p..o..............l............p.p............a........p.......aG.h.p..o....Ph........c.pcVaFlNhpchhshK..........a.GTs..s.P..l.....ht.....Ds....pa......s...................ltlRA..aGsYoh+l...sD.........P.h...h.F....h..s..p......l...l........G....s...p......s...p...a.s...h....s-........l..........p....p.....pl.pu.........llst................lp...s...s....l....s....p.....p...s...h.....s....h..h...pl...s..u...p.t.t-l.uphl...pp...t.l.s..tp.a...pph..Glplsshtltul.oh.s-......-spchlpph................................................................................................................	1	75	138	165
+13264	PF13422	DUF4110		Domain of unknown function (DUF4110)	Coggill P	pcc	Pfam-B_8504 (release 24.0)	Family	This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.	27.00	27.00	30.90	29.60	26.90	25.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.27	0.72	-4.15	56	186	2010-10-07 10:44:02	2010-10-07 11:44:02	1	38	161	0	138	184	0	96.20	32	14.76	CHANGED	tpsssp-shPpP+.PFEoLR-FasRTuspWtphhhsphc....tt............ssK.................EL+KcuFcLuE-+aW-pR-tlptl...E-ppE-.uGlt-llt.tpct-ss.sss+p..........R	.....................................t...shpDshPpPc...PhEoLR-FasRTstpWtphhhsphc.t...........hssK..................EL++cuF-LAE-+aa-tRctlptL...E-ppE-.uuhtEssshspptp........pt........................	0	37	82	120
+13265	PF13423	UCH_1		Ubiquitin carboxyl-terminal hydrolase	Coggill P	pcc	manual	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.12	0.70	-4.98	21	393	2012-10-10 12:56:15	2010-10-07 16:51:41	1	11	243	0	279	8427	287	334.80	20	34.06	CHANGED	sGLEs.phs.ssYhsuLLQhhah.p.shhphlltps.................p.hcpsLhsELuhlasMLc.s...ss.uhssQsoNhLp.shuth......p............Auslst...............................ppslpp...sppFllcplphslhsh...............hhs.........................................................................................................hpsplsp.hhshph.ppt+s...hpsps.....pp...+.s...shhshslshss.......psp.......................................thshsshLcp..hpppp.pp...hhsppspph..ps.........................................................................................................................................................sp.shphpphP.lLsIshthts.p....h...s..hphsp........................................................hltlPhp..hslsph...............................htp-..tppt........shssphhYpLpulVCc..lss.shp.psH.hVShlRVs.......tp..................pc..................WalFND....ahl	.............................................................................................................................................................................................................................................................................................................................................................GhEs..phs..ssY..hsu......l.....LQ..............h.h........aa....h..............h.......h...p....h...h....l...p..ch...........................................................s.....h....c.........s...L....h.....s.......E......L......u...........a..........l....a....p.....M...L...c...t......................up.....s.........s....s...p....s.....o.......N.....h.....l......p....s....h.........p....p.h.............p.........................sss.lth.................................................................................tphhpp....hp.p.F.l...lp.p.l.p............p....h.h..ph..................t.....................................................................................................................................................................................................................................................................................................................................................................t...............l......t.......p....h.......h...s..h..t..h......t...........p..ps..............p.stp..................pp......hp..s.......t.h...h.....h..s.....ls..hss..............psp..................................................................................................................................................................................................................................................................th..s..h..t....p..h...L....c..ps......h.p........p...p...psp...............shCp...p..C....p...ch.....p.s....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hp..p.p..p...l...p.....p.........h....P....s...l....L....s..l.s..h.ph........s.p...........phh..........hp...t............................................................................................................................................................................................................................................................................................th...ls......hp....hp..h...h.h......................................................................................................................................................................................................................................................................................h.tp........t.t.......................t..s..h..h...Y..pL..u.hV....sc....lts....p..hp.....t.sp.h.........V.u....h...l.+..ss...........p.p.................................................................pp........................................................................W.hhFND.....hhl....................................................................................................................................................................................................................................................................................................................................................................................	0	88	148	232
+13266	PF13424	TPR_12		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:B0SDL4	Repeat	\N	32.60	32.60	32.60	32.60	32.50	32.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.70	0.72	-4.04	266	22703	2012-10-11 20:01:03	2010-10-08 09:43:34	1	4096	2284	44	13792	31171	6927	76.00	21	24.33	CHANGED	p....p...h...s....p.s.h..t...pl.u.thht.phschppAhphhppulph..hp.t..h..u.p...p..p...ph.s.ts..h.tsluphhtt.hs..c..h..pp.Ahphhpculpht...pp	.................................................h..ts.h..s........sl.u.t.sht..phG.c......a......c...cAhp..ha.p.cuLpl...tp........h.......G..p............p........p..s..p.......h....u.ps.........h..ssLuts.a.....tp..hG.......c...........h......cc..Ah.p..hapcuLph...t...............................	0	7608	10139	12329
+13267	PF13425	O-antigen_lig		O-antigen ligase like membrane protein	Coggill P	pcc	Jackhmmer:C1ZFT0	Family	\N	33.00	33.00	33.00	33.00	32.90	32.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.27	0.71	-4.20	326	5848	2012-10-01 22:04:45	2010-10-08 16:03:28	1	44	2998	0	1467	5882	1859	156.00	16	35.08	CHANGED	+.h.......h.......h..h.......hs.hhhh..hhslllotoRs.u....hlshhlsh.......hh..hhh.................ht..h.ph+.............hhlh.........hsh..ls..lhslh.......hhh......................hh.tt..l..............................................p...ps..s.o.hss..Rh.p..........h.h......p..thh...p.hh........tp....t........s...h....hG.....hG.......h.s..sht.........................th...............thhh.s.....csh.............a...hp...hhhp.....hGllGhlh...hhshh	.................................................................h...hhhh..hhhh..hh.s.l.h.h..o.t.S..R.s..u......hluhh.lsh.......hl....hhh.................................................ht.tph+......................hhlh.........hsh..ls..lsslh.......hhh........................thht.h....................................................................................................................tt..ps.s.ohss....Rh.t..........h.a.............p.tuh..p.hh.............tp....p........P....h.......hG.......hG.........hsshh...............................................................hhhtsHNh..................a.lp...hhhp.....hGllGhllhlhh.h....................................	0	494	986	1232
+13268	PF13426	PAS_9		PAS domain	Bateman A	agb	Jackhmmer:A3PI49	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-10.17	0.72	-3.65	245	26423	2012-10-04 01:10:46	2010-10-08 17:13:29	1	3737	3198	105	10645	42862	3384	103.90	18	17.69	CHANGED	ssu...lh..lhst....p................splhhsNpsh...tphh...Gh..s...........t.p.....cl..h..u..p.s................h.p...t..lh............................s....tt.....t...........p...t.p..h.h......pp...........ltp..th.p..............ptp....t....h.....p.h..c.hhh...h...p...p.s.......................G....p......h..hhtlphtsl...........hs.p..p..sphh........th.ls..hhp....D...loc	....................................................ulh.hh-.......c..........Gpl.h.h..s.N...p..s..h.........p.c.hh....Ga..s..............t..c......E.l....l....G...p...s................................h..p..........l.h.............................................................................................................s.....sp......t....................t....t...t...h..h...........pp..................h.h..p....tl..p..........................ps.p.........t......h.........p.t.....-....h..th.....h............p......+..s..................................................G.......ph...........h...hh..p..h...s..h.s..s.l..........................................hs..p..p.......G.p..h.h...............th..ls...hh.p..Dlo....................................................................................................................................	0	3685	7467	9280
+13269	PF13427	DUF4111		Domain of unknown function (DUF4111)	Coggill P	pcc	Jackhmmer:Q2YCQ2	Domain	Although the exact function of this domain is not known it frequently appears downstream of the family, Nucleotidyltransferase, Pfam:PF01909. It is also found in species associated with methicillin-resistant bacteria.	22.20	22.20	22.30	22.40	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.28	0.72	-4.20	35	1222	2010-10-11 10:57:40	2010-10-11 11:57:40	1	5	685	0	86	694	11	106.30	45	40.45	CHANGED	Ap-lFsPVPpsDhhcA.lp-olspW......sDhpGDEpN.......l...lLsLuRlWaolpTGpIuuKDtAApWslpRLP.scapslLptAppuYLGptp-shst.psppltsFlpah+ppI	...................................A-clFsPVPcpDLhcA.Lp-oLshWp.......u.sDas...GDE.....RN..................V...VLTLuRIWYoss..T..G......+IusKDVAA-WAhc..R..LP.spa.psllhcA+p.uY.LGp.c.-Dchts...pssplpcFl+asKscI............................................	0	28	51	68
+13270	PF13428	TPR_14		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2Y691	Repeat	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-8.26	0.74	-8.82	0.74	-2.80	819	700	2012-10-11 20:01:03	2010-10-11 12:02:20	1	232	562	0	291	7605	2621	43.80	22	8.89	CHANGED	h.p.h..h..h..t..h.u..p.h..h..h..p..t..u..c...h..p.p...Ahp.h.hpp..h...h..p....t..t..s...s..s...s..p...hh...hth.up..h	....................h..hhh.tl.Aps..h...h.p...t..G...p.hcc...Ahphhcps...Lp.....t.s..P...s.s.......p..uh...htLu.....................	0	121	209	262
+13271	PF13429	TPR_15		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2Y889	Repeat	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.81	0.70	-5.34	27	995	2012-10-11 20:01:04	2010-10-11 14:33:27	1	217	880	3	284	2894	1122	173.90	17	26.66	CHANGED	+l...t.chts...p..ps.h.th..AshhasptchcpALplL.ssscpts.ss-s.....taWRshApLAhsLpc-DtuptAYcpLLssstA.pssDhsphlth...h-usPhcAtclu.huac+s+ssptLppAl.hhpptcsapcltsLLts..hp..t..tst....Ap...pSshhhssRAchhcppGpspsAh+.h+cAlshssusspl+usLLWhLlDtGppsp..h+.hLstacsph.....pDusLWtsaAuAhLhLscsspALpahpp.ptpptppD.LhhhuYADAh-huGpt-tAhplRRpsa+pLpc	............................................................................................................................................tttt.................................................................................................................................................................................................................................................................................................................................................h............h.h........h....h.....p..h....p.......p....h..t....p.......p......h...hpp......h........p.....t.t..............................ht.............s..s.......h...a....h....t.....h...A...p...l.h.t.p.h.s..p..h..st.A...h..pshcp....A..Lc..l...p...P.....s.....s....s....p....h........t.......s.....h....s.....h....h....L...h.....p....p...t..p..h...tp.........h..t..h..l...p...t...hh...pt..............................ss..s..t....h....h..........t....h......u....h......s...........t..h...t..p...........t..s......th...hp.......................................................................................................hhht..........................................................................................................	0	84	161	223
+13272	PF13430	DUF4112		Domain of unknown function (DUF4112)	Coggill P	pcc	Jackhmmer:C1Z9H4	Family	This family has several highly conserved GD sequence-motifs of unknown function. The family is found in bacteria, archaea and fungi.	21.90	21.90	21.90	24.50	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.20	0.72	-4.12	134	487	2010-10-11 14:44:25	2010-10-11 15:44:25	1	7	424	0	240	486	28	104.40	32	53.33	CHANGED	ptl.p+lc+hAhhhD.ps.h.....plsGh..thRhGhD..u...llGL.l..Ps.l...GDhlshhhuhhll.h.pA.pcl....GlPppllh+MhhNlslDhll........G.hlPl..lGDlhDhhaKuNpRNhtLLccaLp	........................t..hp+lcphAhhhDpsh.....plssh...th+h..Gh-..u...l...lGL.l..Ps.l...GDhlshhluhhl.l.h.pA.pph....GlPtplhh+MlhNlslD..hll........G.hlPl..lGDlh.......DhhaKuNpRNhtllcpal.......	1	66	144	206
+13273	PF13431	TPR_17		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2YD44	Repeat	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.62	0.74	-7.98	0.74	-3.31	374	768	2012-10-11 20:01:04	2010-10-11 16:05:33	1	146	199	0	464	10633	7068	36.70	39	7.58	CHANGED	hhpculph..s..Ps.s...spshh..plu..h.h.h.t.........pp.u...p..ht...pA.tp	.................h.KSlEs..D........Ps.s.......upSaa...pLu.p.s.h.S.......................st.G......p.s..st..............................	0	367	402	433
+13274	PF13432	TPR_16		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2Y5H2	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.35	0.72	-3.19	121	9987	2012-10-11 20:01:04	2010-10-11 16:24:43	1	2573	2894	10	3726	30807	9308	65.00	20	12.94	CHANGED	hthApthhptuc.hppAtphh.pphhptt...st....sspshhhhupshh.pt...sphspAh.thhpthh......ptsstss	..................................hu.thhptsc.hspAhphh.ppslptp.................Pp...............sspAhhhL..G.p..shh..pp.................G.chspAh.phhppsl.........phtPt......................................	0	1425	2531	3216
+13275	PF13433	Peripla_BP_5		Periplasmic binding protein domain	Coggill P	pcc	Jackhmmer:Q2Y8R1	Domain	This domain is found in a variety of bacterial periplasmic binding proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.90	0.70	-5.71	64	1016	2012-10-02 13:57:41	2010-10-13 14:55:12	1	18	666	4	355	8653	3387	355.80	48	85.60	CHANGED	IKVGlLaShoGohAloEpolh-sshhAIcEINssG........Glh....G..+..plEsVlhDPuSDhshaucpAccLls.p-+VsslFGCaTSsSRKuVLPVhEctsuLLF..YPspYEG...EsScNlhYT.GAuPNQQslPhlcaLhsphG.........cRhaLlGSDYVYPRpsN+Il+s.h.Lppp..Gu..c..s..lu..EpYhPl..Gp...o..-..apsllscI+....ph....t....Ps....slhSTlsGDuslsFY+thtst.....G.....ls.sp.c.hPlhuhSluEpElpul...ssp....shsGHhuAhsYFpSlcoPpNcpFlppa.+ph..a........G.s.sp..lsssshEA.uYhtlphWspAVcpA....G.os..-s...ctV+pAl.hGp....phsA...PpGt.l.p.lcs..NpHhthsstIGclpsDGQF-..llacoptsltPcPasshhst	......................................................................................................................................................................................IKVG.lLHS..L.S..G.T..M.A..I.S.E..o..s.l....p.D.sthhs...I......-....-...I..N...s...p..G.................G...V.L..........G.....+......p...l..E..s...V..l..h..D......P..A..S......s.W..P.h.F.........A..E...K.A....+pL..l..s......p.D.+.V......us.VF......G.......C.W.T.......S....s.S......R........K....u..V..L..P..V..a...E...c....h......N......u........L...L....a...............Y....P......V......Q.........Y...........E.........G..............E............S........p..........N.......V......F.......Y....T......G...........A........u........P....N.....Q.....Q....u....l......P......A........l...-.......Y....L......h...p...c..p..G..................s+..+...a.a...L...l...G...o...D....Y....V...a...P....R.T.....o.....N...+.I.l...+.s...a...L...c...sc........Gs...............c..s.....l........t.....E....s.....Y.....s.P....h.......Gp........o..D..a....p....o....Il.u....c....IK..ph.........t..............s.......sV...l..S....T..l.N..G..D....S.N.V....s....F....Y....K.p....L....t....st........G.....l.p.....u....s.....c...h....P.....V...l....u....h......S.....V......u.....E....E....E...l...p..G..I.......s....s.c.............sL..s.G...a......l.......u......A.....W.......N....Y.....F.......p.......S.......l......-..............s........P.......s......N.......c.....c.......F...l...p...p....a.....+sh....h......................G...s.....cp......VT......s....D.....P.....h....E..A...s...Y...l..u...h....a...h....W......t......p.A...VE.K.A.....................G....os........Dl..........D....c....V.pt..A.h.....h..G............p..h...s.A...........P....p....Gh...l.....p.....h...c......t...........N.....H.H...l.....p..K...s..s.h...I...G....c.l..p.s..D.G......Q...Fp...lV....a.p..o..s.pslcs.pPassh................................................................................................................................................................................................................................................................................	0	75	185	265
+13276	PF13434	K_oxygenase	L_oxygenase;	L-lysine 6-monooxygenase (NADPH-requiring)	Coggill P	pcc	Jackhmmer:Q2Y7Z9	Family	This is family of Rossmann fold oxidoreductases that catalyses the NADPH-dependent hydroxylation of lysine at the N6 position, EC:1.14.13.59.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.53	69	1152	2012-10-10 17:06:42	2010-10-13 16:42:34	1	13	829	4	434	10129	2446	319.20	29	71.40	CHANGED	claDllGIGlGPhNLuLAsLhcphs.........slsshFl-ppspFsWHsGMhLssuphQssFLpDLVThssPTS.aSFLNYL+p+.s..RLapFh.tcsahssRpEascYhpWsAspls.s...lpFuppVpslphsp...p...t........h..hpVps.....ts...ppp...phhu+plllGsG.ssPhlPss.hpsh......splhHoo.cY.Lpphsp.........tss+plsVlGuGQSAAEIah-LLpc..hs..s...hplsWloRsssahPhDposhspE.h.FoP-Yl-aFasLsp.ppRppllpppcthsasGlstsLlppIYchLYp.p.clp..u.....p....p.hpLhsppplpshpps...s...tt...shpLshcptt.ps.pp...shcsDsllLATGYch	........................................................................................................................hDhlGlGhGPh......NLul..Ashhppht......................th.pshFh-..p..p.......s......p......F..s...W...H.....s..G.M....hls...s.s..p..h.Qs.s.F.....l.pD........L.............V......o..ht.....s.Ps......s...a...SF.....l....N....YL..tp.p...s.....R.l...h...p....F.h......h........c.....p.....h......h........ssR.....p.....E.a....s......-..Y.h....p.....W.....s..A..p...p..h.....s....s..................lp.....a...u..p.p......V...p....s....lc...hst.....................p...................p........th..................ap....V.p......s.......................t.....................p.....p..p...............p..h....h..u....R........p......l..l..l.....G..s.......G.......s.....p.....P....h........l....P......p..s.....h...p...t..h.....................t...p....l....h.....H...u...o.....p...a.......ht.p...t..t...............................thpsc+lsVlG.u.G.QSAAE...l...hh...sL...hpp.......hs..t....................hpl..s..h.l.s..R..p....s.......s....a....t....s.....h......-....p.....o...........h...s...p...E.......h......F....s.........P...-......as..c...........h......F....a......s....h..sp.....p.t..R....p.p................ll.t.p....p.....+.......h.......h.s...u......l..s....c.h......l.....t...p.....I...Yc.....h.l...Yp..p....p....lh.t............................p.....p..hplh.s...s.p.p.l......pshp....tp..............s...........t.......th......p.L........t......h.p............p.....t.....................p......t.........t.........p................tp..h.csDsl.l..hATGYp.....................................................................................................................................................	0	99	242	354
+13277	PF13435	Cytochrome_C554		Cytochrome c554 and c-prime	Coggill P	pcc	Jackhmmer:Q2YA34	Family	This family is a tetra-haem cytochrome involved in the oxidation of ammonia. It is found in both phototrophic and denitrifying bacteria.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.34	0.71	-12.51	0.71	-4.09	93	858	2012-10-01 23:37:15	2010-10-13 17:17:09	1	116	351	4	437	1110	218	122.30	16	25.29	CHANGED	sCh.sCHsp..tt.ppatp.....ot.Htp.hhpsh.t.....ttt..................h...t...........t.sp..spCs.uCHs.sh.thp.s....tsh.....sht......p.........h..........tsl.sChsCH...ssss.sa...spts.ss.sst............h.t..............................hsts.stsstpsCusCHt	......................................................................................t.....................................................................................ptt..ttCh.pCHs..ss.....htp....s......t.sh........st.s..............p.........tt......................................tsl.sCtsCH.......uss...u...pa........tph.s.t.t..t....................................................................................ht......ht.ptp.C.h.tCH..............................................	0	157	293	384
+13278	PF13436	Gly-zipper_OmpA		Glycine-zipper containing OmpA-like membrane domain	Coggill P	pcc	Jackhmmer:Q2YCQ8	Family	\N	28.90	28.90	28.90	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.80	0.71	-4.44	34	349	2012-10-03 03:18:43	2010-10-14 11:39:32	1	7	288	0	122	1054	136	99.20	26	65.73	CHANGED	uCAshPsGPs......hshPusscs..hppFp..tDcttCRpaAtpps...ss..psp.....pss......p.sussu.uslGsu.lGA....usGA.shGs.....upG.AulGA..usGhLsGuAuGusuuphtshtsQ.tpY-suYhQCMhu+	.......................................................................................................................tsp.........psp.........................ppss..su.ussGAA.lGA....ssGu..shGu.......upG....AshGA..uhGuls.Gu.......hs.....G.......u....s.......ts.....p...p.....t.t..........t.....................................................	0	29	74	102
+13279	PF13437	HlyD_3		HlyD family secretion protein	Coggill P	pcc	Jackhmmer:Q2Y7Y5	Family	This is a family of largely bacterial haemolysin translocator HlyD proteins.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.48	0.72	-3.69	147	4655	2012-10-02 20:27:15	2010-10-14 13:36:12	1	49	2429	0	1181	25718	5084	112.10	18	29.22	CHANGED	tlpAPhsGhl.p..t..h..s...h..p....G.ph...lp.s.Gps....lh..p....lhs.........s...p.....h.t.lcsh.l.sspphstl............Gpplpl.pht....s.hst....p...l...pGplppl..u..s......ss....s.......p....psp.....s..ht.....h.....ph..plsss........................thtlpsG	...........................................lpuPhsGh..l..t...p........h..p..............s...p..............G...ph........l......s.....s.......G....p..s.................l.h....p........................l.hs....................h.....s..p................l.h..lp..sh..l.....s.s.....p.........c....l....s.t.lc.....................G.p..p.........l....p....l....phs............s.htth....s......l................pG.p..lpp..I...u..s................ss........s..........................p.......ppp................h..h............s.....ph..phpt..................................................................................................................	0	360	721	990
+13280	PF13438	DUF4113		Domain of unknown function (DUF4113)	Coggill P	pcc	Jackhmmer:Q2Y7D7	Domain	Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, Pfam:PF00817.	24.00	24.00	24.30	25.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.38	0.72	-4.37	197	1492	2010-10-14 15:22:47	2010-10-14 16:22:47	1	11	959	0	244	1129	1436	51.00	46	13.70	CHANGED	sppLMpslDplNp+aG+uslhhAu..p.G...h.p........p..........sWpM+RchhSPpYTTcWs-LPhl	....................sppLMpslDplNt+pG+GslaFAu..p.G...h..p..........p..........pWpMKRphLSPpYTTRas-L.hl................	0	65	133	204
+13281	PF13439	Glyco_transf_4		Glycosyltransferase Family 4	Coggill P	pcc	Jackhmmer:Q2Y6X7	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.96	0.71	-4.55	52	6671	2012-10-03 16:42:30	2010-10-14 16:40:50	1	54	3442	22	2039	11319	3388	166.90	15	42.72	CHANGED	lllsspphtp.huGsEhhsh-LApthtp.pGapVplh...usphsp.htpp........................hhhthshhhthtphlpph..chDll..+.p.........................hhhshHssh.....................h.......hp.h.hhhhthh....h.tsctllAlSptstcplhp.hs....lsp....pclpVl.Nul-tphFp	............................................................................................................................................h.................hu.G..s.t..p..h.hhpltp..t....L....t.p....p....G...a...p....l...h.lh.................s...t.......t..t................................................................th..........................................h.........t...........t.........h....h...........h......t.......h..........h............h........h.......h...........p.......h.......t.........p.....h.......h....c...ph..............ph.D.ll..........Hh.p..t...........h......s...h...h....h...s..h.hthh.................................hph..h.l..t..o....h.Hshh....................................................................................h...h.....t........h..h...t........h....h..h....thh.............hp...p.sc..t...l..l...s.....l.S.p...h...h..t..c.p..lhp...hs.............h...............pplp.l.l......s....Gl-.t.........................................................................................................	0	677	1353	1746
+13282	PF13440	Polysacc_synt_3		Polysaccharide biosynthesis protein	Coggill P	pcc	Jackhmmer:Q2YCG5	Family	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.76	0.70	-4.92	52	1715	2012-10-02 21:24:20	2010-10-21 10:27:40	1	14	1385	0	471	5839	872	248.50	15	56.48	CHANGED	tssshhhtlhlu+hlshpshGh.athshshhs.lhhhl.s...th.Gh..pssh.ht....t..s.tstp.p..htsh.hthsh..hs..shlluhshshh..hlsh...hh..t.s..thh.hh.hluhhhhshhhpthhpthhhsttchth.sshhshlhshhh.hhshlhh.hhhth...slhshhhs..hshuuhlshlhhh.h....htt...hc.ht.hp........shth.h...c.h.h.p.puhhhshtsh...hshhs.hphsh.hl.lsh.h.us..stlGhaps.st.hlhth.hs.lhhtsltphhhPphu.p.t	......................................................................................................................h...thhhhhhls.+.h.h...s...stt.h...Gh...hs..h...h....hs...hh...h..h.h....l...h.....th...th......p......h...ht...............tt...tstp...p..........ht.p....h....h....p....h..s.h........hh........sh.l..h....h....l...s....h....h.....h....h......h.............h....l.sh................hh..........s....s.....t.....p.....h..........h.........................h...........h..........h.....h..........h......s......h...h...h....h...h....h...s.....h.....h....s....h...h...p.....s.......h....h......p...t......t....p........+.......h...ph.....hu.......h.......p......h.....h..p.....s....hh...t.....h..h..st...l.hh..hh.hsh..................sh.h.u.......h..l...lu..........h....h.........h....u...s...l....h......u.....h.........h....h...h..h..h................hht...........tp..h.p...hp..............................ph.ph..h.........c...h...h....p...p....s....h....h....h.......h..h....tsh.................h.t.h.h....t.....tp.....h.........s......t.....h..........l....l.........s.....hh....h...us.............ss......s.G.....h...as.....h....s....h....ph....h.s.h...hs....hhsts.l.sp.hhhsph...h..............................................................................................................	0	144	297	385
+13283	PF13441	Gly-zipper_YMGG		YMGG-like Gly-zipper	Coggill P	pcc	Jackhmmer:Q2YAQ0	Domain	\N	27.60	27.60	27.60	27.60	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.47	0.72	-4.44	284	420	2012-10-03 03:18:43	2010-10-21 10:38:44	1	7	388	0	100	1126	106	43.70	46	28.65	CHANGED	sss..stGAulG....A.usGAs....lGuhsG........tu.s..p....G...................A....h.lGAusG....ussGu.......shGs........t	................psstGuhlGAusGAlhGshsG............ss+....G........................A.AlGAGlGAlsGhh.....................	0	21	55	80
+13284	PF13442	Cytochrome_CBB3		Cytochrome C oxidase, cbb3-type, subunit III 	Coggill P	pcc	Jackhmmer:Q2Y8Z1	Domain	\N	27.00	22.00	27.00	22.00	26.90	21.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.80	0.72	-3.82	488	9400	2012-10-03 10:02:11	2010-10-21 13:26:28	1	190	2200	132	3123	13490	4902	79.30	23	30.40	CHANGED	sss.psGpplY.p.p....sCt.s.CH.u......sG......ss.....u............sslt.......sp...shs........s.............cplhp.......hsh..p.G.......t.....s.....u...MP....shs.t......p.ho-c-lptlssal	............................t..htpGppla..t.p........sCu..s.CH..u..............ss......ut.....G.............................................PsLt......................ss.......sht......................................................................pplhp.................hlh.......p...G........................t.............s..............s.......MP..............uas.t..........tL.s.-.pc..ltslssYl......................................................................	0	889	1958	2631
+13285	PF13443	HTH_26		Cro/C1-type HTH DNA-binding domain	Coggill P	pcc	Jackhmmer:Q2Y718	Domain	This is a helix-turn-helix domain that probably binds to DNA.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.74	0.72	-3.77	196	4823	2012-10-04 14:01:12	2010-10-21 13:31:50	1	44	2292	4	901	17516	1639	60.70	23	55.90	CHANGED	+.Lpph..htc+....ph....shpcL.....t.....c......ts......G.....lop..sslscLtp..s.p.....p.tlsh..ssLpplCphLsC.p.suD.ll....chh..s-	....................................lphh.htc..+........ph....ohpcL.....u........c.......ps.........G..........lop.......sslsp.....l.tp.........s..c................p...s.l.p......h...ssL.p..p.I......C.c.hL......s....s..p....s-.lh.....ph.................................	0	334	628	760
+13286	PF13444	Acetyltransf_5		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:Q2Y7M2	Domain	This family contains proteins with N-acetyltransferase functions.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.61	0.72	-3.44	244	1571	2012-10-02 22:59:21	2010-10-21 13:46:37	1	11	1299	0	478	1970	489	102.60	30	27.02	CHANGED	LRa.pVFtpEhsusspt......t.hD...hDpFD...shscHLllh....-.ppp...............lVGsYR.lhtsstst....th..ts.hYops.F.....c.h.stlts..hhs...phlElGRSsVpscYRsttshhhLWt	..........................LR.psFtpph....suphps.........t..hD..hDpaD....p.h.s.pHLllh.....Dpsp...................c...lVGsYR..lhhssphh....................th.....ss..hYops.F..c...h..st.hht.......hhs...phlElGRosVp..scYRss.t.sh.hLh........................................................................	0	133	304	401
+13287	PF13445	zf-RING_UBOX	zf-RING_LisH;	RING-type zinc-finger	Wood V, Coggill P	pcc	Pfam-B_49 (release 24.0)	Domain	This zinc-finger is a typical RING-type of plant ubiquitin ligases [1].	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.44	0.72	-4.24	80	584	2012-10-03 15:03:13	2010-10-22 16:12:06	1	39	268	1	422	2209	29	41.40	40	9.31	CHANGED	CPls+-....ss.tp.......Ph.h...Ls.CGHlls+pslp+lsp.......tt.................p.....hKCP	...............CPls+E.....osp.pNs............Ph.h....Ls.CGHsls.+c.sLp+Lhp..............ss......................p......h+CP............................	0	166	244	345
+13288	PF13446	RPT		A repeated domain in UCH-protein	Wood V, Coggill P	pcc	Pfam-B_2127 (release 24.0)	Domain	This is a repeated domain found in de-ubiquitinating proteins. It's exact function is not known although it is likely to be involved in the binding of the Ubps in the complex with Rsp5 and Rup1.	24.10	11.40	24.20	11.40	23.80	11.30	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.82	0.72	-4.56	66	317	2010-10-22 16:03:35	2010-10-22 17:03:35	1	11	124	0	248	350	8	60.80	23	12.16	CHANGED	hhshppAhphLpl.ccsssD-hllosaphKls........-sP.s..phchh++ALphIAcpRpSth..LhpFLps	.......................shtpAhph..L....t..l...s......p......s....s....s.D-..hllssaptphp..........ssP..s...phphhpcALphIAptRpSth..Lhphl..............	0	59	132	216
+13289	PF13447	Multi-haem_cyto		Seven times multi-haem cytochrome CxxCH	Coggill P	pcc	Jackhmmer:Q2YA36	Domain	This domain carries up to seven CxxCH repeated sequence motifs, characteristic of multi-haem cytochromes.	21.90	16.20	21.90	16.20	21.80	16.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.52	0.70	-5.33	11	1428	2012-10-01 23:37:15	2010-10-25 16:31:19	1	16	119	2	112	1635	47	181.40	54	67.74	CHANGED	ppVGCIDCHu.....slst.pphpHppc.......LtMPstssCGsCHlppFAE+EuE+cs......W.........Pptp.........Ws.G+PSHulsacA.NV.EsuhaAuMspREVApGCsMCHsp.QN+CDuCHTRHpFSsAEARcPpACusCHsGlDHNEaEsYhhSKHGslapsptc.pWsapsPLK-Ah.pcGG.TAPTCssCHMEacG.-aoHN.lsRKlRWu.sP.sPtIA-sl..sp.WhEtRh-uWlsTCspCHSspFA+saL-thDpGphpGlshhpEAcplltsLYcDGLLsGQpTNRP	..............................ss....................................................................................................................................................................................................................................................................................tGCT...F.C..HT...........s.....p............p........+.........Cso.CH..p.RH...pF...s.s.t.......AR+...s...E.pCps.CH.h.G........KD........HRDWE..AYDISlHGs.......VYQlN..K........a.D...ashp....ctL.u.D.A.D...YVGPTCQYCH....M.....R.....GG.....H..............HN.VQR.huTV.................Y............TS.....M.....GM..S...........A...D..RG..................A.Pl...WpEKR..DpWsSVCDDCHSPRFAREpLQAMDEAsK.D.AG.LK.Y.pE.TFKVAEsLhhDGhh-PMPKD..Ls...........................................	0	45	90	107
+13290	PF13448	DUF4114		Domain of unknown function (DUF4114)	Coggill P	pcc	Jackhmmer:C1ZAY0	Family	This is a repeated domain that is found towards the C-terminal of many different types of bacterial proteins. There are highly conserved glutamate and aspartate residues suggesting that this domain might carry enzymic activity.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.23	0.72	-3.16	74	320	2010-10-25 15:42:29	2010-10-25 16:42:29	1	61	151	0	82	297	55	84.00	22	9.76	CHANGED	phsuG...splua....hLhssuhssthht.............................h...ao.sshN.............ss....hp.....phtshttsst...h......lGaEDhh.....uD....p..DaNDllFtlphss	..................................................................................h.tG.tluhhl.hssuhttthht...................................................h.aohtshN............................ss............hp.............ph.tshtsss......hh..............luFEDhh.s..........uD.............t....DaNDllhtlph.........	0	26	59	81
+13291	PF13449	Phytase-like		Esterase-like activity of phytase	Coggill P	pcc	Jackhmmer:Q2Y944	Domain	This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins. 	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.38	0.70	-5.17	51	1288	2012-10-05 17:30:43	2010-10-25 17:12:27	1	51	942	0	459	1415	255	314.60	19	66.08	CHANGED	phlGp........hslssshthsu.........sthGGlSGlsass.psstaaslSDcts....sssRaYshplsh....tst..thsslphtshssLpcss..................Gpsa...........h.DsEulth..sssslaluSEGc.....tt.h...Phl..hchs.hs.Gph.hpch.sl.Psthh.t.t.................pGhcsNhuhEuLolss-...Gp......hLasAsEss......LhpDustsp....tt.......sRllpachts.G..ts....htpahY.h-sh...........stsGlo-llAlsspt..hLslERu...au.u...................hGtsh+laplsls.s..upsssshsslt....s....lsslpKpLlh-htp.......s.h...lDNlEGhshGshh.-GppoLlllSDNNF......ss.t.QpTphlshplp	...........................................................................................................................................h.h................s...........htu.h.Sulhh............t........t......s............h....h.sl..sDps...................................t....h.hhh.hph............................t.sth.ph.h..p.h....h...lp.css...................................................................Gt.sh.......................................DsEulsh................ss......u......s......halusEhs...................Phl....hchs.....ts...Gph....h...t.......h.....s....h...Pssh..................................................hthpp..stGaE...ulshs.s..-...Gp.........hLa.shh....pss....................l.h..p.cs.t....t...................hRllpa...sht...s.....t.............................htta..h..Y.h-t......................tshsl.u-hshlsspp...hlllE..Rs....t.s......................................uhhp+.l.ac....ls...ls..t.....t........................h...........t.s........h..tt....t................t..............h.h.hptp...l..h.s.h....................................s..h......h-phEGl....sl.............................................s......s........p.......p..........lhlhs.Dssa.......................t.s.hh..............................................................................................................................................	0	109	269	375
+13292	PF13450	NAD_binding_8		NAD(P)-binding Rossmann-like domain	Coggill P	pcc	Jackhmmer:D2BHP8	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.46	0.72	-3.95	465	10693	2012-10-10 17:06:42	2010-10-25 17:56:16	1	305	3705	149	4167	53665	24260	63.30	26	12.65	CHANGED	IVGu....Glu..GhshA.th..h..s.....c.....p.....s..h....c..l..hlh-...p.c.sc.lG..Gps.h.sh...ph.......p..u........hhh.c.hG.s+.ha.ts.......t........tt...hh.c..hh...cp.l	.................llGuG...hu..G.LssA...hh...L..s..........................c.............p..........G...h.......c.....V...hl...h.E............c....p....s.......p.....h.....G.......G.p.h....h....sh....th.........................t.................h.p..hs...............................................h.......................................................................	0	1314	2568	3528
+13293	PF13451	zf-trcl		Probable zinc-binding domain	Coggill P	pcc	Jackhmmer:D2BIP7	Domain	This is a probable zinc-binding domain with two CxxC sequence motifs, found in various families of bacteria.	21.50	21.50	21.50	22.20	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.73	0.72	-4.33	91	388	2010-10-25 17:00:03	2010-10-25 18:00:03	1	9	215	0	117	275	17	49.10	57	50.87	CHANGED	pDKsLsCKDCGpEFVFTsGEQEFY.tE...KG.F...p.NEPsRCssCRcARKpppss	...tDKsLsCKDCGpEFVFTsGEQ..EFYtE...KG.F...cNEPsRC.sCRcARKpppp..............	0	65	108	113
+13294	PF13452	MaoC_dehydrat_N	zf-MaoC;	N-terminal half of MaoC dehydratase	Coggill P	pcc	Jackhmmer:D2BH16	Domain	It is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.39	0.71	-4.37	39	2537	2012-10-02 20:54:35	2010-10-25 18:06:56	1	31	1010	26	1023	4405	1494	127.80	17	29.40	CHANGED	shlGpph..ss.hp..hplppuplRtFAcAh..Gp......ss..Ph.YhDptsApts.ta.sl.APPTF.hh.sls.....h.....ss.......hh.....ptl...s..ls..h....tplLHG-.Qpapa...cp...s.lhsGDplshpspls-lh-.Kps...Gs.h.calshcopssspcGchVush	..............................................................................t....................h...hsttplh.ash...ul...ss..............tt...s....hhs.t.............................s.h.h.s....P...s.o....a..sh..l.hs....................h..........ts..............................hh..........tl.........s....hs....h..................hpl..l...H..s...s.....p.phph............t+...P.....l.h...s...G.-p...l.psp.sp.l.ss.lhs.+.t.....Gp...s..sh....ls.hc.sp.h.p..p.t.p.G.p.lh..h...................................................................................	0	248	602	865
+13295	PF13453	zf-TFIIB		Transcription factor zinc-finger	Coggill P	pcc	Jackhmmer:D2BJR6	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.48	0.72	-4.76	126	674	2012-10-03 10:42:43	2010-10-26 09:24:28	1	7	520	0	270	585	125	41.10	44	38.76	CHANGED	pCP..pC.p.s.s.hp.....hhcp..............pu.lplDhCs.pCcGlWL.DpGEL-+llpp	..............CP..hC.ps.s.lh.........hs-+..............pu.lcIDh..Cs.pC+GlWL.D+GEL-+llp.........	0	84	174	240
+13296	PF13454	NAD_binding_9		FAD-NAD(P)-binding	Coggill P	pcc	Jackhmmer:C2D2T2	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.08	0.71	-4.45	180	1586	2012-10-10 17:06:42	2010-10-26 10:52:14	1	24	1273	0	358	3901	1444	156.50	25	30.28	CHANGED	AIlGuGspGlsshtpLhpph.......t..ts....lplplh.-s..t.sh..G.G...tsaps..s..p..spthlhNssusph.ohhscps.............ssahcWhp.....spt......................ths.s.ps..assRtlaGcYLpthhpphhp.ph...st.th...plph.h.p...s.cls...s.lpt...ps......ss....h...h.l...hh....s.su..p..s...h..tsDtV.lLAsGps	.............................................................AIlGuGssGlhshh..pLlpp......................tss......lsls...la.-p.....s...th....G.........G.........hsat.s....p.....p....st.h....L.h...N..h..s..u.t.p..h..s.h.h.sp..........................................................ssa..h.cW.hppppt..........................................................t..sh..p..s..p..p.......a..h.P.R.......h..l.......a..G.cY.h....c....p...h.........h..pth......hp....ph......p.hh.......p.l.t.....h.h....p......s..plh......s...l..p.......ss...................ss.........h.....hl.......th................s.ss.....t......s..............h...shDhl.lLAsGp.h......................................................................................................................	0	84	201	290
+13297	PF13455	MUG113		Meiotically up-regulated gene 113	Wood V, Coggill P	pcc	Pfam-B_48720 (release 24.0)	Family	This is a family of fungal proteins found to be up-regulated in meiosis.	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.99	0.72	-3.53	212	101	2012-10-01 19:55:08	2010-10-26 13:41:55	1	2	86	0	70	797	308	100.00	30	25.08	CHANGED	hKIGhTs...ss.pcR...lpphppts......shphpllthh.ht................................sstclEphlHpphps..tRlpt..................EaFc....lsh.....pplpp................s.......lcch	..................................LKIGRus....NV.p+R.lspWpcQC........spplpll+ha.hhs.p.t.............................................................phsscs++lERLlHlELss...............hthpt.....t.Ct.tC....s+.......pH.....pEaFc.lps.........pphtt................l...l............................................................................	0	20	39	58
+13298	PF13456	RVT_3		Reverse transcriptase-like	Coggill P	pcc	Jackhmmer:D2BGL4	Domain	This domain is found in plants and appears to be part of a retrotransposon.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.62	0.72	-4.20	89	3907	2012-10-03 01:22:09	2010-10-26 15:56:17	1	208	854	5	1534	3767	350	81.20	25	12.10	CHANGED	s.h..........AEhhAl..ltGLphAhphGhp.+lhlpuDuphllptlpsp...hpsps.phstllpclcplhpp.Fpphplp+lsRcsNpsAcsLAp..hutpt	......................................s.p.AEhtul...lhuL.p....h..A.h......p...h........s...h.......p....p........l..h.l...hs.D.SplVl...p..pl...p.tp................hpsp....s...p...ht........h..h..pp....l..c..p..hhp....p....F..p....t....h......p..l....p....al.............R....p....p....N..ph....ActLAp.u...t.....................................	0	197	508	925
+13299	PF13457	SH3_8		SH3-like domain	Coggill P	pcc	Jackhmmer:C2D335	Domain	\N	21.00	5.00	21.00	5.00	20.90	4.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.66	0.72	-3.82	69	1627	2012-10-02 18:48:24	2010-10-26 17:18:41	1	78	162	3	111	1462	0	74.30	26	36.50	CHANGED	ss.cslshpuplp..pspsculas.pshthsuspplss...ups....Ysspp...lplh.ccApTs+........u...o......ahph...........ph....supslGWlDpcAhs	...................................................pcslshhshVp....s..ssssu..las.t..Phtss.usp.p.......sst...........lss........Yps+s...lpl...+cApsst..................................s..s........WYpl..........ph.....sspsIGWlcscsh...........................	3	37	65	98
+13300	PF13458	Peripla_BP_6		Periplasmic binding protein	Bateman A	agb	Jackhmmer:A3PL33	Family	This family includes a diverse range of periplasmic binding proteins.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.94	0.70	-5.09	259	10778	2012-10-02 13:57:41	2010-10-27 11:15:08	1	73	2751	52	3781	13919	6511	334.70	19	81.74	CHANGED	sl+lGllhsh.o...Gsh...u...ss..upshhsusphulcphN.t.s.G...............Glt....G..c.....p..lchl.ht.D.sts.ss.stssptucchlp..p...cp..Vts.lh.sshsossstul.ts..hh.pp...ps.h..........hl....s.......ss..........t.....hs........s....t....p.s......ss.t...ha..hh.s....h......ss.t.tp..st......shspa............h......h......p......p.h........G........sp......c.hh.hl.s..ss..hshu.psh.t.p...sh..pph.hp....tt.Gsp..ll.............sp....hhhs...h..ss....s-....h..ss....hltp.lps..u....tsD..................s....lhsss.susssss.hhcth..p.p....t.G.....ls........t..h.hh....u.hs..ht.psp..l..tsh.......us....ts...s.p.......G.....h.....hhs.ss....ah......s......h.....s..s....st..........sptahppa..pp........t....h.............s.....p..t............s.s.t.htt...s...uYhus....thh....h.pAl.............cp....A.........G........s...s..s.....sps..........l....h................ps.l.c.s..hs...h.....s..........s.......s.h...........u.t..hth.........h...s.s.....s.pp..s....h........p.s...hh...lsp.lp......ts..u...p	..............................................................................................................l+lGhhhs.h..o........G.sh.......A....th....G.p.t....h.pGh.p.h...A..l.cc.lNt..t..G.........................slt..........G...c.........p....l.pll...hh..D.....s................t......s.....c............s....p.p........u......s....s...s....s....p.c.....l...l..s...........................cp....lt...h..l.l.G....s....h..s.S.u..s...s.h.s.s..ss.....l.h...pc.......t.t...l.......................shls...........su..................................s......ss.............s......p.........ps....t..t...h.....ha....+h..s........s....................ss....s...tp....ut................s.h.up...a.......................................h.............h..........c........p..h........s.............sc..........+.l.u..ll..t....ss.....ss...a.....G...pu.h...t..p..................sh...pps..h.c........t...t...G.hp........ll............................t.p......t.th..s...........h....ss........pD..........a.....s.u...........h..l...s....p.....l..p..s.......t.................s..s.D...................................................................s.........l.h.h...s.s.......h...t...s...p...s..s........hl.+....p.h....p.p.....h....G............hp...............s...........h..hh........uss......hs...s..s...p....h...ts.h..............................us........ts......s..p.........................G..........h...............hh.s..ts........hh........s...............p...s........st..............................................sp..t..a....h..p..t...a....ct.....................p....h.............................................................s....p...........................s...s..h....h..sh............h....uYsus.......hh.l....h.pA.l......................................pp...s..........................u........s....h....s............stt..........................l.h....................................................p.s...l.p.s.....hp....h.....p............s........s.h.............G.......h.t..h............t....t.p......s..t......h......................h.h..h.h.p.h.......t.............................................................................................................................................................................	0	935	2299	3103
+13301	PF13459	Fer4_15		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:B0SHL0 	Domain	\N	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.71	0.72	-3.41	122	1717	2012-10-03 08:56:43	2010-10-27 11:35:52	1	33	874	0	647	2723	504	59.90	29	46.40	CHANGED	lhVD.c..spClGstt...Csths.....P.csFph-.s.c.u.hupsh...............h.................hssc.ppphp.cA.hcsCPsssIpl	........lhlD.p..spCh.Gsuh......Chths........P....-.l...Fp.hc.-.-..G..hstlh...........................................h.ss.s.tp.ppsp..cA..scsCPspAIp..............................................................	1	174	451	575
+13302	PF13460	NAD_binding_10		NADH(P)-binding 	Coggill P	pcc	Jackhmmer:C2D4U5	Domain	\N	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.94	0.71	-4.28	74	14495	2012-10-10 17:06:42	2010-10-27 11:37:19	1	78	3768	30	5105	51820	16534	186.90	17	65.92	CHANGED	IsllGAsGpsGptlspchhpcG....hpVpuhs...Rs.ss....ths..........thphlphDl..hsh...tthspslp...G..hDsllssh......ush...tt...........c........tp..s..sp....pllcshp.t...s.s..sp.+.ll...l..l.uusu...hhp.....stpth..............h............h.h....ttt..t.ts.....-.....chl....p..s.s..sl.sWThlpPut.hhps.......t...sp....phph.....hts...........ss.....s.t.....st.....shlshpDlApshl-tlps	......................................................................................................................lhlhGA..o...G....h...l..G...p......t....l...s......p.......p......L.........h......p........p......G..............t...p..V.....t......u.....h....s.......................R.....p.....s.p...............p...htt............................ts...h....p......h........h.........t........s........D..........l......p.s......................t.s....l.......t.......p.......s.......l.......p...........s...............h.......D.............s........l.......l...h..sh....................ss.h..tt........................................................-.................................hp.s....sp..........p..l.....h....p...u.......h....p....t...............s...s........lp.......+......h..l.............h...........l...Su...h.u................s...t..................p.t...s.........................................................................h..h........ps.c.......t....ts..........-............ph.l............................p....p....s.......sh.....s....h......s....l....l...R.....s..u......h....l..hss..................t.....tt.............hth......hht..............................................................h...........t.l...t.h...t...D...hAthhht.h..t...................................................................................................................................................................................................	1	1558	3201	4341
+13303	PF13461	C-term_anchor		Cell-wall surface anchor repeat	Coggill P	pcc	Jackhmmer:C2CZF8	Repeat	\N	27.00	27.00	27.30	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.04	0.72	-3.50	178	2550	2012-10-02 15:23:12	2010-10-27 14:32:45	1	182	317	1	148	2314	6	59.40	35	18.55	CHANGED	YlDp.sGpp.ls...ssps..loGp..lGcsY....so.....psc....sIsG.....Y..plsps.....sssts.GsFs.pss.psVsYV..Y	........................YhDp.sG..pp.ls....ssps....loGp........lG-sY....so..................psc.......sIsG.................Y...sLsps................ssNss..GsFs..sss..poVsYVY................	0	51	84	132
+13304	PF13462	Thioredoxin_4		Thioredoxin	Coggill P	pcc	Jackhmmer:B0SES9	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.08	0.71	-4.23	52	3857	2012-10-03 14:45:55	2010-10-27 15:14:37	1	30	2252	39	1197	5536	2874	166.60	17	66.73	CHANGED	ss....s..shh.lGstcAslsllEYsshsCPaCsp.app.p.s.h..p.lhpc.YlcsG..Klpalh+ph....hs.c.s....lhAuhh...ucs.stp...s...phF.h.hhpphhhpp....ppt....hsps.........pt........hs........tp............sssh.....t.cp.h.t.sh.pss.p.hpshl.t.t.pp.p.u.cps.slp.sTPohhl..sGch..h......s.shsh-chpthI-p	.......................................................................................................................................ts........G......s.u.....l.sllt.ahDapCPa.C....t....p....hp............t..p....l.....t.....p....l..h....c...p......h..........s..s........c.l...p..h..h..h+..ph................sh......sps..............uht.A.u..ts..............u.ts...s..tpp...........s.........pha....h.hh..c...p...h...l....h..p.p............p.pt.....hspt................pp............hs...........tp..............................................................tshs......h.pp..hpp...sh......ps....t....p....h......p..p.t..l....p......p......s...........t.p...........h........u.......p..........p...........h.....s....l..........p......u..........TP.o..h..h..l.........sGph.....h.........t..t........s.....p.th.thl........................................................................................................................	0	389	766	1022
+13305	PF13463	HTH_27		Winged helix DNA-binding domain	Coggill P	pcc	Jackhmmer:D2BJI8	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.92	0.72	-3.65	61	2080	2012-10-04 14:01:12	2010-10-27 15:25:49	1	20	1390	11	608	21196	2353	65.80	23	40.16	CHANGED	lot.phhl.Lppls........ttpptph.sclsthhshc.psshs......tslccLhct..Ghl..t..tp..spt.....thhplTscG	..................................................phhl..L.h.tls...............tppthoh..sc....ls.p.t.h....s.lp..pssls......pslcpLhcp........Ghl.....ppp.ts.....p.D+Rp...........thlpLTspG........................	0	154	358	487
+13306	PF13464	DUF4115		Domain of unknown function (DUF4115)	Bateman A	agb	Jackhmmer:A3PK73	Domain	This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.34	0.72	-4.33	73	1846	2010-10-27 16:37:37	2010-10-27 17:37:37	1	11	1803	0	409	1357	405	75.40	29	23.46	CHANGED	ltlhss.tsuWlpVpsADG...pllhpslh...psG-shsl....ssptPhplplGsuu.ulhhslsGpthss.ushup.spsspLohs	...................lshshs..uc.sWlp.Vp....D..u.s.G...+pLh....s..G.hh...+tG..p..s.hsl....supsPhc.l.plGssu.uV.plph.sG.cslcl...uthhp...sp.sschsh.t....................	0	117	257	347
+13307	PF13465	zf-H2C2_2		Zinc-finger double domain	Coggill P	pcc	Jackhmmer:D2BGQ7	Domain	\N	22.50	20.00	22.50	20.00	22.40	19.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.11	0.73	-7.56	0.73	-3.41	163	227898	2012-10-03 11:22:52	2010-10-27 17:41:20	1	6697	1851	312	138033	194266	376	25.80	50	27.05	CHANGED	pLppH...h...p.p.Hp.......sp.c.....s....a.......pCt..h..Cs..tpapp	......................LtpH.......p.............R..l.HT........................GE.K.....................P.....Y...........................cCp.......p..CG...KuFs................	0	21562	34039	60664
+13308	PF13466	STAS_2		STAS domain	Bateman A	agb	Jackhmmer:A3PG87	Domain	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [1].	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.33	0.72	-3.95	89	3458	2012-10-02 18:52:36	2010-10-28 17:48:09	1	38	1847	0	1117	4550	627	79.20	22	51.70	CHANGED	LpLsGplsh.psss.s.Lhptltt..hl........ts..s.....pl.plDhutlpphDsuulslLhphtptstt.ps.pplpl.ps.sss.t.lt.plhplhGls	......................................lsGclDh...ssss...s..lh.pthtp.....hh...............pt..s.....tl.sl..DLuplshlDouGlulLlph.hcp......s...p..p......pG....t.plpl..t.s..s.ss..p.lt..plhplhsl.............................	0	371	742	971
+13309	PF13467	RHH_4		Ribbon-helix-helix domain	Bateman A	agb	Jackhmmer:A3PHV5	Domain	This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.08	0.72	-4.09	57	610	2012-10-02 18:44:02	2010-10-29 13:14:09	1	3	438	4	200	495	214	68.70	37	66.55	CHANGED	t.hpR.......SlplsGHpTSlpLEstFWshLc-lAppcuholspLlucl.....Dtpp.......................cs.NLuSslRlhsLpalp	..............t..hpRSlplcGtsTSlpLEshFWphLc-IAspcshol.spLlucl.........Dtp+.......t..............ch..NhuShLRltsLpal.t.......................	0	50	109	147
+13310	PF13468	Glyoxalase_3		Glyoxalase-like domain	Bateman A	agb	Jackhmmer:A3PMH5	Domain	This domain is related to the Glyoxalase domain Pfam:PF00903.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.42	0.71	-4.36	115	1009	2012-10-02 15:00:03	2010-10-29 13:27:31	1	8	863	2	301	1880	849	182.90	23	72.75	CHANGED	lDHlllssp..sLspussth.p..pLGhshs..........sGGpHs.th..........GTpNtLlhh..u..s.....s.YlEll.u...l.c....Ppts.......................ss....t....ts..p.h.athc......................php.....p......s..sultshsh........cs...sDl..sssttpht..........p.t.G...........p.h..phst............sp.....lpWchs..hhts..sthsh...........tshhPhh....IpWtss....c.s.............p.......ts.ss.shslppltl...sss..cs...stht.thh......stlh	...........................................................hDHllhhsp.....sL-pshph...........h.p..thGh...p..ht......................s..G..GtH.s..th...................GT.tN..p..L.h....h...h....s....p................s..Y..lEll.s....l..c...sspp..........................s.....t.ts..p.hhshp........................hhp...t......stGhtshsl..............cs.....sDl..pshppchp...........p.pult.....................st.h..ph-t...............tp......lcWphh...hhts..tt..t........................phthPFh...I.pWpps....ct..................tp.......a...ss.shslpslhht.sp..p....ppshphh....h..........................................................................................................	0	84	176	244
+13311	PF13469	Sulfotransfer_3		Sulfotransferase family	Bateman A	agb	Jackhmmer:A3PS36	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.13	0.71	-12.53	0.71	-3.29	403	1788	2012-10-05 12:31:09	2010-10-29 13:28:25	1	182	817	11	719	2609	1547	224.00	14	47.11	CHANGED	phlhl..hGhs.Ro.G.....................oohlp.tlh.........................................................................................................................................................................t.tstthhhttt...........thhthhttthh.tthttht.....thhhhh.h.ttthh.............................................h..h.thhhh...thh...............................hh..........csshph...................hh.....lhhh..Rc...Ph.th..hhs....h...htt...................hhtht.....h........................................................................htthhhthtt............................................hp..ph.tt..pthh.ttlht.h.t.....plspt	.........................................................................................................................................lFl..hGhs.RS.G....................TThlp.tlL.............................................................s...t...............................................................................................tts.thhht.t.....................................thhtt..hhthhh......tthtt.ht........th.h..hh.htth.tt.h..................................................................................................................hh...h.thht..................................................................................t.hh....h...KsPtphh.h........................................................lhthaPsA+hlhhh.Rc.....Ph.ss......htS...t.h............htt...............................................................tht....th.....................................................................h.thhhth.........................................................cphhtcP.t.h.pplht.h.......t..........................................................................................................................................................................................	0	256	451	586
+13312	PF13470	PIN_3		PIN domain	Bateman A	agb	Jackhmmer:A3PJ99	Domain	Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.69	0.71	-3.43	201	1089	2012-10-03 20:43:45	2010-10-29 14:04:15	1	5	687	0	443	1286	243	110.50	21	70.24	CHANGED	plV....lDTNVll.....sull.......................................sthllphh.....hpsthpsh...hotpllpEhtpsl.......hc...t....hthttt.....t.h..ht...............................................................thhpsh.hhsh.....t....D...scDp+hlssAls.........u....p...AshlVTtsh+	.................................lllDTNVll..........ssll..t.............................................sphlhphh.....t..psthphhhosphlpEhtpsl.......t+.h.t....h.thpthtt....hhhhhh................................................................................thspsh.....ht.......hp.......D....cDphhlssAls.........u......p......AchlVTtst....................................................	0	161	315	393
+13313	PF13471	Transglut_core3		Transglutaminase-like superfamily	Bateman A	agb	Jackhmemr:A3PJ09	Domain	This family includes uncharacterised proteins that are related to the transglutaminase like domain Pfam:PF01841.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.75	0.71	-4.30	84	283	2012-10-10 12:56:15	2010-10-29 16:51:48	1	7	246	0	123	398	53	113.40	20	54.94	CHANGED	hlhhlshphhhtthshtth...httts.tst.sssstpph......pplspslptsup....hhPhps....tCL.pulusthhLctp.GhssslhhGVppp..........s..htAHAWlp.sssth.....ls.st...tshppasslhs	....................................................................................h.......thhh.hhs.h.h....h.t...ths...tt..t.sptpph......pphspslptsup.............hsshcs....sCL.pulusthhLp.pp.s.h.s.sslhlGltpp.......................shtAHAWlc..sssth....ls..st....tthptas.l..t.......................	0	38	92	106
+13314	PF13472	Lipase_GDSL_2		GDSL-like Lipase/Acylhydrolase family	Bateman A	agb	Jackhmmer:A0LCN0	Domain	This family of presumed lipases and related enzymes are similar to Pfam:PF00657.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.24	0.71	-4.14	323	11620	2012-10-02 11:02:24	2010-11-01 11:55:58	1	260	4043	70	3589	11502	2666	188.90	16	56.62	CHANGED	lhlGDS..hs...tG......h...s..........s.s.....................t..t........t........sa...s..th..l...tp........................p.........t....t........s...h.p.h.h.shuh..sG...s.s...st.....p...........................h...........h.t.......p.htp............................................th...............ttps..c..ll.hl.t..hG.s.NDhtt...................................................................t.....ht....hpp...htpt.lpp...l...lpp.h...........p.s.ps......p........l.l.l..l....s.h...s..shh..tts...................................................ttthp....ph.s.....p...t.l.......p..........p..h...u...p..p.t......s..sh.hl...c.htss.....ht.....s........t.........t.......th......t..p...h.ht...................................sDs....l...HPss.tGhphh	...........................................................................................................................................................hlGDShs.....t.G.....h...t...............................................................................................tt......t.......sa....s....th..l....tp............................................................t.............t...t..s...h.p...l...h...N...hu....h.......s.G...t...s...st....p.................................................h............h.t.......p.hpt...........................................................................................t.h.....................ttps...c........hl..ll.t....hG.s.NDhht.................................................................................................................................................................................................................s........hs...h.p.p....h.tps.lp....p...l......lpp.l..........................................p..sps..........p...........l.l.l..h......s..h....h....s.ht..tht........................................................................................................................................pphhp......ph..s............p....h...h............p.....................p....h......u......p...p.h.............s.....s....hl......s..hhth.............ht......s.............t..............................t........................t.......hht................................................................................................sDs......l....H.st.tGhth.........................................................................................................................................................................	0	1283	2468	3145
+13315	PF13473	Cupredoxin_1		Cupredoxin-like domain	Bateman A	agb	Jackhmmer:B3CV67	Domain	The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.17	0.72	-4.14	62	2319	2012-10-02 17:41:00	2010-11-01 15:20:39	1	22	1660	14	491	3072	708	105.60	23	33.67	CHANGED	thhhlhh..hh.hhsp.....sst..........s..ssptp.....hplplp.ss.........tapPsplplsuGp.hp.lp.lcNpsss..........s..tEac..c.....Lp.hc.cslssGpsspltlssLcsGcYpFhss...hp...p..+GpllV	.............................................................hth........................t.....................t..sshpp......lpls.l..p...st................................tapPt..pls.lpsGp.sp.lh.h.p.N..p.ss.p..................................s...p-h..h.c................................ht..hc....c....s......l..s...s.G......t.p......p..s..l.p.h.s.s..ps.Gc.Y....phsCs.......h.....ph....t...+GplhV...............................................................	0	136	300	392
+13316	PF13474	SnoaL_3		SnoaL-like domain	Coggill P	pcc	Jackhmmer:D2BK05	Domain	This family contains a large number of proteins that share the SnoaL fold.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.52	0.71	-4.07	92	1249	2012-10-03 02:27:24	2010-11-01 16:36:19	1	78	757	19	493	3716	1050	118.60	16	47.55	CHANGED	lpphhspa.tpu.hspsDh-thhshhs.....-csshlG..ssssch..hh....stpphpphhcthh....s.p.s...p..shphph..t..p.hpl....p...t.s.s....ssuhhst..hhph......h......p.h.....t.h...Rs.osl..h.c+pss..sW+lsHhHhS..h..shs	........................................................thhpta.hpA.hpp...tD...hcs.h.h.s.has.................sc....s.......s....h.......h....t.......s.s....s.......th.......hp.........Gh.p....t.h....p...p....h.h.p...t..h..h................s..t..h.....p......sh.p....h.p.h...p......p...hpl.............p......h..s..s....shu...h..st.t....t.h..ph.............p..h.....t...spth............tthh....+s....T...h..l.......h.p+..p......s.s......t.......Wc..lsphHhS......t....................................................................	1	171	331	420
+13317	PF13475	DUF4116		Domain of unknown function (DUF4116)	Coggill P	pcc	Jackhmmer:D2BI90	Domain	\N	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.51	0.72	-4.47	608	1708	2010-11-01 16:51:33	2010-11-01 16:51:33	1	50	79	0	1429	1843	1299	48.20	25	44.03	CHANGED	D+-l...lhps.....lc..ps....s.h.............slpa...s...s...pp.....L....+s........D+......-l...lhp...A..lc.......p..ss....p..............s...l....pass...p................p.l.c	...................................................s+-llhpA..lp...ps....u.h.....................slpa....s...s....cp.......l.+s.........................D+......El.....lhp....Alc............p.ss....h....................s...l.....pahs.t..................................................................................	0	1384	1406	1429
+13318	PF13476	AAA_23		AAA domain	Bateman A	agb	Jackhmmer:A0LBT8	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.82	0.71	-3.99	469	5945	2012-10-05 12:31:09	2010-11-01 17:09:13	1	57	3641	10	1564	18355	6884	299.00	13	41.98	CHANGED	plplps..a.tsa...............p.s.....t...p....l....cF................sp......s.............l..s........lIhG.t.......N.........GuGKoTll.-Al....p..h.s.L.....h.u.....ph......tph...ppt.................................pt...t......tht........ptph.p...........ht.t..........................................ptp.t...tsh.....hclp.............................hpt...tpt...................................................................................................lp......ptp..ht..p...p....pt.pth...............p............tt............t..tp....hh..ph...............pp.h.p.....p..h...lpp................ht..tp...tt.....................................................th...p.....h.....h.h...h..hspp.p.........................................t...........................pp......p....................................................................ph.p.t..h.......p.pt...h.......pp..h..p.p..hpp..........h.......hpp.........................................................................h...........................pt..pp....hpp.......................................php...pl....ppplp...ph.......p..clp	............................................lplps..h.tsh...............p.p......h.....p....l.....-F.......................ss....s.....................l.s...............l.lsG.t...........s...............Gu..GKo........oll...-.Al........p........h...s.......L......h...s...ps.........th..ppt.............................................tt.................ttph.......h.........................................................................................t.p.t....tt.......hpht...................................hp......ttt..................................................................................................................................................................................................................................................h......t.....hh............t....t..t.......................................................t.........................h...th...........................tt..t.....p.h.......htp......................hht...t...t...............................................................................h...t............h..h.ptp..........................................................................................................p...............................................................................................................................................................................................................p..t...h.......t..t......h......tt...............................ht...................................................................................................................................................................................................................................................................................tttt.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	583	1015	1360
+13319	PF13477	Glyco_trans_4_2		Glycosyl transferase 4-like	Coggill P	pcc	Jackhmmer:D2BIQ3	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.05	0.71	-4.34	45	1823	2012-10-03 16:42:30	2010-11-01 17:19:16	1	17	1376	0	466	6381	2986	141.00	15	38.32	CHANGED	Klhhlusss...p...h...a...s...h...+...a....spt...Ltpp....Gh-lclho....css....pphth..ttth.phhpl......p.s......hps....hph..l..p.h....h.pl..p+llcchp.PDllHsHhs..psh.ulhutlh....h.htt.h..shl..losaG.s...Dl...hpt..spps.........hh..ch......lh+.h.shp..pustlh.ssu	.....................................................................................................................................h.........h........h........t...h................hpt.......hh.pt......sh.c..lhl.ls..............psth.......t.............p..hh............t..s...h....p..h..htl..............................s.ht.......................ppt..........hp.......l.....p...h.........................h...pl.....h+....l...l...+.....c....h......p.....D.l.la...s...a......s..h......p.s........s....l.....h....u...t....l.u...s.......p...h....s....t......h.......th.l........h...s..h..p....G...h.........sh........hpp...s.ht................hh.ph.............lh+....h.....ht.....sp.hh.....................................................................	0	196	332	414
+13320	PF13478	XdhC_C		XdhC Rossmann domain	Bateman A	agb	Jackhmmer:A0L5F2	Domain	This entry is the rossmann domain found in the Xanthine dehydrogenase accessory protein.	27.00	27.00	27.00	27.40	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-3.86	296	2511	2012-10-10 17:06:42	2010-11-01 17:23:08	1	15	1622	6	738	2055	1067	138.90	30	40.65	CHANGED	LllhGAGclupsLsplAttl.G.acVsllDsR...................p.....p.....t.....a.......s...........ts.....sp........lh........sh...s........................t..p..th.......ttl.......p..hs..s.ps...h..l..l..h..THsa.p.hDh.tsLpthL.p.p.........s.st.YlGhlGS+p+ttphhppLt..p..Ghs......tpplsc.lpuPlG.Ls.IGucoPpEIAlSIlAEl	.....................................lllhGAGclupslsphushL.s.acltlhDsR...................t.....p.......hF............P............s..st........lt......s.h.s..................................s.th.......tth.......p.lsspo..h..l..l..l.THshp..hDh..sLptsl.cp.........s.st.YlGhlGS+++ptphhccLp.tc...Ghs.........cpclsR.l+uPlG....ls.lGu....coPpEIAlSlhAEl..........................	0	233	476	620
+13321	PF13479	AAA_24		AAA domain	Bateman A	agb	Jackhmmer:A0L701	Domain	This AAA domain is found in a wide variety of presumed phage proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.46	0.70	-4.75	49	566	2012-10-05 12:31:09	2010-11-01 17:32:31	1	4	488	0	83	510	154	223.00	18	78.95	CHANGED	spsh+hllYGtsGhGKTohstsh....scsLhlDh-sG...htsh.....tscslplp..............sap-htc..............................h...htpp...ls..pYcslVlDolophpchhhthhttp...thscp.sts....hpsYGhhs.pthhphls...thhp..hstsllhsAatspcp.....phsthshh..phts....pstsplhshsDhV..s.h.....t..pt..........Rhh.hpsssthhuKs............................................pLss	.................p...hphhlYGpsGsGKT....o....hs..pph.................spsl.....h.....l.D.h..-.tu..t....h.p.sht.........ssss.l.p..lp...............shpphtp.........................................hltth.t.pp......tp..pacslVIDols..ph...p..c.h...h..htthh........tt.cp.sp..........hpsauhhs...pph.hphlp.......plhp....hshpllhs.....u.+psppps.........tss.t..hspht.phps.......phts....tlhs.sDll......sphth......pttst..t....................thh.h.p....p..h...sc.p.................................................htp.hhh................................................................................	0	35	62	70
+13322	PF13480	Acetyltransf_6		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:D2BI49	Domain	This family contains proteins with N-acetyltransferase functions.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.60	0.71	-4.23	211	1584	2012-10-02 22:59:21	2010-11-02 10:42:47	1	24	914	0	667	4625	1145	142.00	14	36.55	CHANGED	pphR...p....pl+ppt...++h.p....c.h....u...th.ph...ph......s...p....ss....p.s.......hp.t.......h....hphh.......h...p....p.....hptp...........sh...hs.p.s...hht.p...ahcplhp...phtt.......ts..t...h.p....lhhlp....h....s....s..c....h...lAsh..hshhpss..phh..h..hhsua..c.p.....h..s...chuPGhlLhhphlcpshp....p....G..hp.t...hDh....st........G.......s....p...........p....YKp	................................................................................................t....tph+pth+ch.t........c..t...u......h..ph....ph............t....p....s.s....p.p................hp...t.......h....hphh.......t....p....t......hptp...............sh.h............hst.p...ahpphhp...th..................ts...p....h..c................l...h.h.lp..............h.......s........s.....c..........h....l.A.s.h.......l.s....h.....h.....p......s............s.........p.......hh.........h.......h..h....s.....u....h......ctp.........h..p.....phus...s..t.lL....hh....ph...l....cts.hp.....p.....G..hp..h.....h-h....sh............s.......t.................................................................................	0	248	474	580
+13323	PF13481	AAA_25		AAA domain	Bateman A	agb	Jackhmmer:A0L707	Domain	This AAA domain is found in a wide variety of presumed DNA repair proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.11	0.71	-4.90	101	6612	2012-10-05 12:31:09	2010-11-02 11:53:00	1	60	4750	17	1429	15488	5931	168.50	30	36.74	CHANGED	ttp..th...phhs.......hs.h.tt....hss.t..ss....hchllp....s.....hls...tus...hshlsGtsssGKohlshsluhslu..........................pGt.hht.......h.s...pt.spVlalssEss...tt.plp...cRlpt.ht..........tp.h.....................st.....sph.hhhp..................t...................t......h...tt..hppltphlpp..ts....ssllllDsl..sp...hh..ss.....sp..ss.s.ss....h....tthlptlppl.tp.ph.s..ss.llllcHssKs...ss	......................................................................h.t.................c...h.o.sh..tE.......hsR.VLG.....G............GlV...sGo......ll.Ll....u.....GsPGhG......KSTL.L.L.p.hs.s.p.lu................................p..............................................t..tp.lL.Y.....l....o.....G..EES........hp...Ql.p...........h.R..A..p...R..ls...............hst........................................................................spl...hl..h..s................................................................................................................................................cs.s...l.c.p..l.t..t..t..l..c.p....tp............Pc.ll.l.ID..SI.....Qs....h.h.....ts.................sh...su...s...ss.....................h......Rcsss....t.Lh...c.h...AK.......pp...s..........hs..lhlVG.HlTK-G.t................................................................................................................................	0	493	948	1211
+13324	PF13482	RNase_H_2		RNase_H superfamily	Coggill P	pcc	Jackhmmer:D2BIZ8	Domain	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.09	0.71	-4.43	108	1043	2012-10-03 01:22:09	2010-11-02 12:04:53	1	24	932	19	331	2850	1595	173.30	19	32.29	CHANGED	lFaDIETs.......Gl..tstt.sh.....l.aLlGlhhh.....ps..sph.t.....hhp..hhhc.p..s.t-phhh......p...........ltph...sh.....lssaNGpsFD.hshlc..phh...........p.hp.hs..............th......t......al.....DL.h....p...hh.....pp..hsh.........pu....uLKslEch.lGh.p+..c..ss..lsGtpulhh...a......p......p......ah...css-......ps.........h..LcpllpYNcpDshsLhpLhshls	..............................................................................................................hhDlEss................s....h.............t.sp............h..hlh.......G.....h..h....h.........st....pph...........................hht....h.h.h..p....s........s.....tcpthh..........................p.h.....................thh.p.pt......s.h..........................h.hs.a..shp........s........a.-.hshl..pphh......................tph.t..hst...............................................sh......t........hl....D..L...h....p.....hl............cc..phh....................pu.huLKs....l........pph....h..Gh.......ph.....c..ps...h.....s....Gt..p..u..h..ph......a.......................p..............p.............ah......p.p.ts.............tp.......................h..h.p....plh.pYNcpD.lhuhhtlhphh.h..................................................................................................	0	128	259	310
+13325	PF13483	Lactamase_B_3		Beta-lactamase superfamily domain	Coggill P	pcc	Jackhmmer:D2BIZ6	Domain	This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-11.10	0.71	-4.53	85	2488	2012-10-02 15:46:01	2010-11-02 12:47:16	1	7	1789	3	832	7626	2715	181.30	21	68.69	CHANGED	plpalGHusaLlc.s.s.....G.hpllsDPa..............p.......t...hGh..h.st........................hpsDlVhhSp.sh.D.Hsss.....ssl.s...............................tspllts......................s.........us..........hp.l..s..sl.tlpsl.sssp................cph...s.Gh...ph..........s.s...Nsha.la..p...s.....GlslsHLGchsp..lstpph..ttlu.clDVlhlPVsG.......s.hshstcpuhclscpLpPplllPhH	.......................................................................................ploahGHushhl..cs..s.............s...pp..lllD.Pa........................................................t..........t.sh...t..t.....................................................spsD.h..ll..l.oH...sHs....D.H.h..ss..................p..h..l..tth............................................................................................................ttps.t.h..l..ss.............................................................................G.........sp............................hp...h.......s.....th...p...l.p....h.s...tuhH...................................................................ss.........p........................................s........s..s....G....h.....l.l.....ph.......t.................sh.p.l...a....H.....s.....G.....D.s...........s.............h.............................t.........h...........t.p...h.......t.....t........lD..l..hh.....l.......Plus.............................sh.sh.s..p.p.A....s..h.h.p..h..l.p..s..p.h.slPhH......................................................................................................................................................................................	0	285	572	722
+13326	PF13484	Fer4_16		4Fe-4S double cluster binding domain	Coggill P	pcc	Jackhmmer:D2BJB3	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.49	0.72	-3.23	562	3179	2012-10-03 08:56:43	2010-11-02 13:29:30	1	73	2633	0	658	3760	1232	65.10	42	16.23	CHANGED	hC.ss.Cst.ChcsCPs.....sA......ls....ts............p..h.c.sp.p....................shsh..................hht..h....c.s..hh...st...hc.sh...h.............hh......huCs...h.....Ct..tlCPaN	.............C.Gs.Cst.Chct.CPT.........sA..........ls....ts............hp...l...D..u.p.+....................ClS.a.........................sh..ph....c..G...hh....s-.p...hR.sh..hu....................scl........YGCD...s.....CQhlCPaN...................................................................	0	209	436	555
+13327	PF13485	Peptidase_MA_2		Peptidase MA superfamily	Coggill P	pcc	Jackhmmer:D2BH64	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.89	0.71	-4.10	226	1955	2012-10-03 04:41:15	2010-11-02 13:30:43	1	88	1162	0	810	8921	2335	137.20	14	25.04	CHANGED	sssu....ht.....h...stt..thlh..............h..........t...h.....t...s............tt..ts.hp.......tlltHEhsHhhhtp.h...........s..........s.....................s.......thP..hW......hsEGlApahs.......................tp..........................h........p.s........t.......ht.tthtt...tht..ps....ph....hs..................hp...p......l.......pt..sh...................pttpss......h...sY...t..puhhh...spalt.....p....p.h....G...p.p......pl.tp.............h.lp.....ph	.............................................................ht..............................................................................t....t.hh.......tl...lsHEl.sH..h...h..ht..th.......................h.s.......................................t.....pts.....hW........hsEG.hAp..ahs......................................tp....................................h...pt.............ht..tth...tp..........hht.......pt......ph.....s...........................................ht...p..........h............ts..........................ttt.htt........................h....sY.........t...tuh.h.h.......h.thlt.......p.....t..h.....G..........t......hh.thh...h.................................................................................................................................	1	380	616	731
+13328	PF13486	Dehalogenase		Reductive dehalogenase subunit	Coggill P	pcc	Jackhmmer:D2BJ91	Domain	This family is most frequently associated with a Fer4 iron-sulfur cluster towards the C-terminal region.	24.30	24.30	24.70	24.80	23.80	24.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.07	0.70	-4.97	89	620	2010-11-02 15:39:17	2010-11-02 15:39:17	1	12	161	0	63	596	74	241.20	24	54.61	CHANGED	ush++PWWVKER-htcPTsElDWslhp+.hD....hppt.th.......................t.t.h.t.h.s..t............t.....htpttp...thtpthppphPGhshps.......................hALt....tuht....s...h.t....sh....t.s.............................shhs........s..sT..P-phG..lP.+WpGT.PEENhpMlRAAh+aaGus.pVGshEl.Dpps+.Klhastst.............................spth.sa.ED..l-..csYp.........sssphlIPs+s+.ahlsasshps....p-hh+ps.............ss...h...t.....ss.u.sh.huYsp..tshlp.sphppFl+uLG.Ypul....s.......s...s.........shsss..suhulhoGlGEhuRhs.hsl.oPcaGshhRh..hthlTDLPL	..................................................................................................................................s.....sWalpph-..p...oh.lDWs.h....t..................................h..................................................thhtp...st.t.t.........................Al.....u.........................h................................h.t............t...tths..hs..hWp.GT.PEEN.thl+sAhphhGus..l.Ghh.l.spp....h...p...phhhtht...............................h.h..h.ps..h......sh...............sstphhhPpphp..hlshsh..s...-hhcps......................sh...ht..ss.sshhs.Y.phs.ht.hhltpFl+sLG.Ypu..h....s.......t...s............shh.s..sshu.hhuGlGEhuR.u..hl.sPca..Gs.hh+h...hthhTDLPL.............	0	25	57	57
+13329	PF13487	HD_5		HD domain	Coggill P	pcc	Jackhmmer:D2BI63	Domain	HD domains are metal dependent phosphohydrolases.	21.80	21.80	21.80	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.90	0.72	-4.00	81	3171	2012-10-01 20:28:14	2010-11-02 15:49:01	1	216	1158	7	1242	5797	561	64.10	32	13.77	CHANGED	ss...Los.p-pt...h....l.p...p+shhshphLpp..l......P..........ht.......pls...cllstppEphDGoGaP.c.uLpu-pIsltuRlL	......................................tLospEhph....h..ppHshhG..hcl.L..pp..h.......................s.............................ht..................tlt.......c.l...s.h.p.H.HE+hDG.o.G.YP.p.G.....Lp....G-pIsl.uRI......................	0	538	906	1111
+13330	PF13488	Gly-zipper_Omp		Glycine zipper	Coggill P	pcc	Jackhmmer:C1ZB73	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.40	0.72	-4.32	279	2160	2012-10-03 03:18:43	2010-11-02 17:37:02	1	18	1426	0	437	2410	297	47.50	42	26.37	CHANGED	hG.ushGA.ssGAhlG....s...s...s....G......s..t.......s.tG.Ahl.GA.u....lGussGu....s....lG....p..t....h.cppp	.........................GAslGA..hlGAsl..G......s....h....s......u.........s.p.......t.cG.AlI..GA.u....lGA....ssGu....h....lG....h.h....h.-.p.....................	0	116	258	352
+13331	PF13489	Methyltransf_23		Methyltransferase domain	Bateman A	agb	Jackhmmer:A0LD74	Domain	This family appears to be a methyltransferase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.06	0.71	-4.52	129	14355	2012-10-10 17:06:42	2010-11-02 17:48:41	1	362	3944	67	5881	52099	19466	173.70	14	51.54	CHANGED	htp.th......ph...ht.......phl.pp...hh.................ttst...................p.lLDhGsGsG..h..h..................................hp.hh....pp...............p..........G.......h.....p..ht...shD........................................................................................h.....................................................pp....................................paD..hlssh.cllEHlt....s...st................phlppltp...h.l..p..s.s.Gh..lhlps......h.................................................ph..htp..................h.t..h.....h.........ts......sHh....saa.......otpslptlh.cpt.G..ap..lhph	..................................................................................................................................................................hhh...............................h...........................tst..................................p..l..L.D.lG.s......G..s....G....h....h.............................................................................................s.t..hh...........tp..................................................t.............s....................h.........p..lh.....GlD.h...u....thhphst.........................................................................................................................................................................................................................................................................sp..................................................................................................paD....h...l....h....s.....h.....p.....s........l.....p.....a....ls...........-.........t...........................................p..h...l...p...p...h...t...p................h...L.........c...P.......G...G..h.....l..h....h..ss..........sh....................................................................................................h........................................................................................................................................................th..............h.h...................t.............h........h.h.....................t......................................................................................................................................................................	0	1716	3566	4946
+13332	PF13490	zf-HC2		Putative zinc-finger	Coggill P	pcc	Jackhmmer:C1ZG19	Domain	This is a putative zinc-finger found in some anti-sigma factor proteins.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.68	0.72	-3.98	461	2372	2010-11-02 17:57:24	2010-11-02 17:57:24	1	52	1229	16	847	2033	89	34.60	27	15.34	CHANGED	C.p..c.hp..phlstalDsp....Lstt.p..p.tplcpHLtpCssCpp	...........C......h.....thltsal-Gp....Lstt.c..p.tplcpHLtsCspCp......	0	368	627	768
+13333	PF13491	DUF4117		Domain of unknown function (DUF4117)	Coggill P	pcc	Jackhmmer:C1ZFF5	Domain	This family is frequently found on DNA-translocase FtsK proteins at the N-terminus. The function is not known but might well be enzymatic.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.19	0.71	-4.81	92	2646	2010-11-02 17:57:43	2010-11-02 17:57:43	1	4	2575	0	664	2313	1905	162.10	24	17.91	CHANGED	p+hhcEhhhlhhhhhulalhluLlSa...s...ssDPu..............W............sp......sss..ss.ts.lpNhuGhhGAalADh.hh.h.lhGhuAahhshhh...h...hhs....aphhpp................p..............p..p............ph......hhch......huhhlhll.sss.ul.h....uh.phhth....t.......th.shs.sGGllGphlush....hhphl..GhsGuh......Ll..llslhhluh..slh....sthS.........................W...l...pl...h-............plG	...........................................t......hh.hl.hhhhhshhlhhu.lhoa.........s....tD.su...............a................................sp......ss..........hpNhsG.hhGAaluDhlh.h...hFGh.hAah.lP.lhl...h...hhs...hhhhpp...................................p......s.tp...........th........sh+.h...........l.G.h....l.h...l.l.l....ss.s....u.l.h................s.l......t.....hs............s.....................h...h.u...uGGllG.t.h.l.u.s....h...........ht..s....h....l....sh.h....G..us.......l.l....Lls..l.hhhul......hlh......s..shohhplht...........................................................	0	226	437	557
+13334	PF13492	GAF_3		GAF domain	Bateman A	agb	Jackhmmer:A0LBX7	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.34	0.71	-10.37	0.71	-4.04	153	4956	2012-10-02 14:34:25	2010-11-03 10:47:51	1	693	1936	7	1590	12597	1586	135.70	16	20.13	CHANGED	sh.c..plhpps........hph.lt.phh.s.sct.....ss.lhh...h.c..ps..pt.th......phh...ssh.....t..ptth..tt.....................................................sl.s.......tsp.s.lhp.....tshppt..p..h..h....h.........s........h.......tt.......p......p............h....................h..s.s..........t............sh.........hh...lPlhs...tt.................pshGlls.l.t.....p.t.........s.tp.p.......h..s..t.pph.phlpt..hushluhulpp	......................................................................................................................................................................................................................................pplhpph...hph..lt..phh..s..hcs........ss...l..hh........h...c......pp.........tt..ph............phh....ssh........tt...p.......................................................................................................................ph.s...........hsp.s.lsp.......ts..h...cpp..........p....s.......h......hh.....................ts...................h..........tp...........p........s...........t........................................................h.s.h...................p.....................sh..............lh...lPLhs.......ss.......................phhGllh.l..t.....p..s..........................p..tp..t....................a...s...t..cph.plLpt....hAshlAhAlpp..................................................................	0	627	1138	1442
+13335	PF13493	DUF4118		Domain of unknown function (DUF4118)	Bateman A	agb	Jackhmmer:A0LBX7	Domain	This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.47	0.72	-3.84	102	1922	2010-11-03 11:55:06	2010-11-03 11:55:06	1	58	1608	1	460	1522	70	101.40	25	13.48	CHANGED	th..l...cshlhhhlshh..lshhlts.tts.....h.t.sh.hh...h...ha..l..lslll.hu.lta.Ght.ulhuull..u.hsh.....hhhhh.h.t.h.............shhhht.p.........hhhhhhhll....lullsGth.ssthppp	........................s....slhhhhh..ssh....hs.hhh.t...hst......h....s..hh....h...la..L.LuVlllA..l.hh.G.h.h.s.ullAull..ss.ls.a.....shaFh.s.s.h..........................ohsltcsp............YllTFslhLh.lullsusLssth+.................	0	139	291	383
+13336	PF13494	DUF4119		Domain of unknown function, B. Theta Gene description (DUF4119)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0594	Family	Based on Bacteroides thetaiotaomicron gene BT_0594, a putative uncharacterised protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2]	27.00	27.00	80.80	80.60	22.10	20.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.23	0.72	-4.00	3	17	2010-11-05 17:33:43	2010-11-05 17:33:43	1	1	16	0	1	13	0	95.60	61	72.61	CHANGED	pcSKKsuKNNsuspph+olE+..-+Qs+-EIIScDELEKRsGITGDt+tYLTsaLRpFhEG-tHpsYsKKLpsLAcYIaDp+ILYIsKHGGYKLMElS	.............puKKGSKNsKsKRNVQThcKAPs+pSKEEIISEEEL-NRIAIoGDIRLYhTMaL+IFIDGaF+HPKKKKLINLAQYIYDQKVLYIHKHGGYKLMELS.	0	1	1	1
+13337	PF13495	Phage_int_SAM_4	Phage_integr_N2;	Phage integrase, N-terminal SAM-like domain	Bateman A	agb	Jackhmmer:A0LBL0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.63	0.72	-3.66	83	3438	2012-10-02 14:21:04	2010-11-05 17:53:17	1	21	1789	4	599	5743	1666	84.40	20	27.95	CHANGED	llcphppth.+h...cthuhpTpcsYhhhlpp....alpah....p......+..........p..P.pphssp-l..........ctFLstLs..pcp.....susuTppps...lsALhFhacplLppshst	................................t.hhp....h..ph......tthS...pThpsYhptlc.p..........Fhp.ah.......t..........c................................p........p..p...l...s...s...p..-....l........................ctalsaLt........c+p.........................hShsThspt......hsuLphh.ap.hlhpp................................................	0	213	418	518
+13338	PF13496	DUF4120		Domain of unknown function (DUF4120)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2585	Family	Based on Bacteroides thetaiotaomicron gene BT_2585, a putative uncharacterised protein.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	27.00	27.00	27.30	38.90	24.70	26.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.42	0.72	-3.97	6	44	2010-11-05 21:26:43	2010-11-05 21:26:43	1	1	29	0	6	29	1	93.80	70	87.90	CHANGED	KIhC.QEHY-pVVpYAKSIsDpTLQpClERLKQWEcNsssPCEIELYYDaAPYSFGFspRYPDGpsGIVGGLLYHGpPDcSFAVhl.pPFHGWoIHT	....KIhs.pEHa-pVtcYAESIGDToLQcCLERLKpWEcNPstPsEIpLYYDHAPYSFGFsp+YPDGRpGIVGGLLYHGhPDcSFAVTl.pPFHGWpIHT............	0	1	6	6
+13339	PF13497	DUF4121		Domain of unknown function (DUF4121)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2588	Family	Based on Bacteroides thetaiotaomicron gene BT_2588, a putative uncharacterised protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	27.00	27.00	27.70	27.50	19.20	18.70	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.67	0.70	-5.38	7	50	2010-11-05 21:42:42	2010-11-05 21:42:42	1	1	30	0	9	43	1	254.20	40	94.59	CHANGED	psps+YslEoLpphNs.aD+tatlsQcDVDhsNRhlplIEpsRSchh.PpsGDplhYloRpGDaaspAhI-thss+p..lpIC..P.lPFsacstsslthsspGGsap.lpscslK.suhppttF+sWGHsGtCuNGuVhFpApV.hWpYpEP-PLYGcaT..Tcsap+aalpKp.-sE..st.hYpu.shshhscp-hcphlt.hcGplFpG.hpsplVlWsaRh-ahhLs.pEWpphc..Ap.Rhh.ht.p.VKIlpDh-pHhshFY	................hpshYslEoLphLNhh.DptaslscpDV-KVNphlp+hEcsRschh.PpsGDslhYlo+tGDYaspAaI-phs..s+p..lpIC.hPpsPFsac...stpshthsspGGsashlsscpl+.suhpptpF+pWGHsGtspNGuVhFcAhVthWcYsE.P-PhYscaTT+pWp+aaIc+ps-.E..su.hYpu-shohhsc-ELcphls.hcGplFpG.hssp.hllWsaRh-hhcl.sstEWpthct.sphRhhahthp.VKIhpDccpHlsThY................................	0	2	8	8
+13340	PF13498	DUF4122		Domain of unknown function (DUF4122)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2607	Family	Based on Bacteroides thetaiotaomicron gene BT_2607, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	27.00	27.00	52.90	41.70	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.46	0.70	-4.97	3	36	2010-11-06 00:25:54	2010-11-06 00:25:54	1	1	27	0	6	28	0	204.50	43	88.78	CHANGED	EEIVYLSIRluCsuYLLYKVaGQK+RIccICDLLYuK.PPVK+ccsEsV.suEPGu-o-VMGSTRFVYLDENAGKTVAPYMSQPLETuuDFIGEEEDVsEEEVECKLPLEEMRMLKEEQEELDucSPEVEAVSPsVTPcDL-NlG-VLh+LN-AspDEsKShRAAhTLHSIRETDLFElFSSQVENKslIEELMGKYLDc-GNPLPLR+c+c.NPVs-sWRQ	...............................................tllYhslRhsChsYlLYpVht.+c+ltpl..CsLLYs....shpp.ctEps...spssss..t...s-VMGpTRaVYLDENAGKTsAPaMSQPLE..p-hIGEDEDIsp-DVECpLsLEcM+hLp-EQEEL...Du.ps...P-sEslo.ulT.cDlpNVGDVLhphstA.pDccKuhpAApTLa.uIR-TslF-lFsSplpNpphlEcLlcchlDc-GNshPL+ppp.p.spssspWR.p.................	0	1	6	6
+13341	PF13499	EF-hand_7	EF_hand_5;	EF-hand domain pair	Bateman A	agb	Jackhmmer:A0LDI7	Domain	\N	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.30	0.72	-3.83	146	22951	2012-10-02 16:17:27	2010-11-08 14:23:57	1	974	2128	881	12350	22877	1126	70.20	26	23.94	CHANGED	plpp....h...................F.pt..hDtsp..sGhlshp.-ltphhppht.......................................ppphpp.........h....hp..phDts..tcG.plshpEFhp.hh	.................................................................................................................................................................................................t..pp.....s...............F..ph....aD.p.D.s......sG.hI...o......tp...EL.pp.hh.p.s.h.s.............................................................................................................................................ppph...c.p.............................hh.....h..hp........ph..Dt.D......sD..G..pl..s..ap.EFhph...................................................................................................	0	4511	6719	9545
+13342	PF13500	AAA_26		AAA domain	Bateman A	agb	Jackhmmer:A0L3M2	Domain	This domain is found in a number of proteins involved in cofactor biosynthesis such as dethiobiotin synthase and cobyric acid synthase. This domain contains a P-loop motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.16	0.71	-4.71	55	5230	2012-10-05 12:31:09	2010-11-08 15:01:41	1	28	3140	43	1197	6492	1083	206.80	25	57.02	CHANGED	+slhloGT-TslGKTllossLspuh.........p..ss.....YaKP.l.QoGht........p.ss.........Dsphl.pp...lhshsp.s.hh....hs....................................................psht.lptPh.oPph.uAph-.s...hsls....lppl................p.lsp.s..s........chlllEGuGulh.VP.lspp.ph.hDlhppL......shsllLVups...sL.G.o.......I.N+s..L....Lolcsl.+.....s.....+....sl.s..lhGllhNs......tss...........c................shptl.pph.st.........l......slL.uplPhhsplss.pp	.......................................................................................thaloGT..cTsVGKTslotuL.hpu..hpp.......................pG.hp..ss......................s.aKP....l...ssGsp..................................p...ss............D..s..thl....pp.............h.s....s....h.....s....h.....s....hp.....th.....................................................................................................................................................s.P.ht....hs...p...s......h......us........pl....uu...p....t..s......h.s.l.............hppl................................hpp..l.s.p..p..s..........................-hllVEGu....GGh.......h.....s.......s.......h.......s........s........p.....t.........s.......h.........h.......-.hspph...................ph.P..l....l..l.Vsss....pl..G..s..................l...sc..s.....h.....L.o.h...p..s.l..p.....p.....c.........s.l..s..lhGll.hNc........h.tss..............c....................................th.t.hl...t...p...h...hs....................h..........Pll..G..tlPh........p.........................................................................	0	335	731	1019
+13343	PF13501	SoxY		Sulfur oxidation protein SoxY	Bateman A	agb	Jackhmmer:A0LE08	Domain	This domain is found in the sulfur oxidation protein SoxY. It is closely related to the Desulfoferrodoxin family Pfam:PF01880. Dissimilatory oxidation of thiosulfate is carried out by the ubiquitous sulfur-oxidizing (Sox) multi-enzyme system. In this system, SoxY plays a key role, functioning as the sulfur substrate-binding protein that offers its sulfur substrate, which is covalently bound to a conserved C-terminal cysteine, to another oxidizing Sox enzyme [1]. The structure of this domain shows an Ig-like fold [1].	22.00	22.00	22.20	22.00	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.32	0.72	-4.01	101	444	2012-10-01 19:22:21	2010-11-08 17:43:11	1	3	280	16	196	483	305	109.60	32	55.82	CHANGED	shhpshhGspsh......ssplplpu...PphAEsGuhVPl..slpss.h.......lcpltlhs-pNPsPhsusFph.Ps.supst..lusRl+lspsosVpAl.ucst.cGphah.usptVKloh.GGC	............................t..hpthhGstsh...t....sstlplsu...PplAEsGusVPlsl....ss..s.hst.........lcpltlls..-p.....N....PsP....hsA...sFph..Pt....sststluoRl+lup.oosVhAlucst...DGphah.usppVKVoh..GGC....	0	44	122	160
+13344	PF13502	AsmA_2		AsmA-like C-terminal region	Coggill P	pcc	Jackhmmer:B8J2T2	Family	This family is similar to the C-terminal of the AsmA protein of E.  coli.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.25	0.70	-4.99	168	2606	2012-10-03 05:41:17	2010-11-10 11:25:13	1	26	1712	0	739	3716	1170	219.90	17	21.31	CHANGED	luplpsplph...p..s..s.........sl.plsslp.hs..hssupl..ss...sup...a..ps..p.........ss..s..p...........sphshplpstslsphh.......pt.hs.hss.......s..l.p.G..p..hs...hshplsh.p.sss.ht....t.h.soLsG...shphpltpG...........plt......p..........................hp.ph.......................shsshhsp...........sh.sa....cslpushplpsGhhps.cs.hplpus.suplshp.GphsLsp..pp..lshphslssphst.hs.hsh...................hh.hhht..htphs....sl........pa..p..lsGshssPp	......................................................................................................................................................................................................................................tphphphth....p....s.s..........tl..plppht.hs...h.h.t.u.pl....pu........sup....hts..s.............ss..t...p..............................sph.p.hp..l...p.s.hs..ls.t.hh.......................................ph.hs..hss....................................s..l...sG...p....hs...hs.h.s..l...ph..p.sss..ht.....s.....h...ssL..sG..........phphp.l.t.pG......................plp.........ph........................................................h.hp............................................................................thshpsh.hsp.......................sh...hF.....cslp.....u..s.....h...pl..p..s....Gl.hp...s.ss.h....h..l......p.....us...t.u.....p......l.s.....hp..G.pl...s......Lsp............pp......l..sh....ps...sls.sphs.t.......................................t...h..tt..h.........l.................ph..p..lsGshspP......................................................................................	0	242	470	596
+13345	PF13503	DUF4123		Domain of unknown function (DUF4123)	Bateman A	agb	Jackhmmer:B5FDW6	Domain	This presumed domain is functionally uncharacterised. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important.  This domain is sometimes associated with the FHA domain.	22.20	22.20	22.20	22.20	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.57	0.71	-4.15	139	819	2010-11-10 11:40:33	2010-11-10 11:40:33	1	3	345	0	199	758	13	123.60	20	45.28	CHANGED	phYhllDusph.s.p.....hhpthh..pt..t.t....t..hts..Latss.shppht.phuPa..Ll......pl..................s............s......h........tphhpp....t...tpsh..........u....h.hlt.......S.s..t.........shp..plhp...HL+p..hl.pl.ph.s.p.G.c.th..hhRaaDsc....lh....tsh......lssh..............tptst.......hh	...........................................................hahllDshhh....p.....h.tth.....th....t...t..hhs.Lattp..sh..ttlt...phuPaLlpl.................ts................s....hl........pphhtp............tt.tt.h.............u....h.hlt.......S.s..t...................................sh.s..pLt.p...HLpphlt..s.ph.s....p..G.c.ps..lhRaaDsclh.sh..hps.hs...tpht.h...............................	0	40	78	125
+13346	PF13504	LRR_7		Leucine rich repeat	Bateman A	agb	Jackhmmer:B5ETY5	Repeat	\N	22.00	7.00	22.00	8.30	21.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.69	0.76	-7.30	0.76	-2.74	1228	2943	2012-10-02 21:32:02	2010-11-10 13:37:07	1	941	590	28	1121	55766	2241	18.00	36	3.46	CHANGED	spL....ppL...p...l..............pp.....s.....p.....l....p......p.....l...s	........................sL...cpL...s...l.......us...N......p.......L..s.....p...LP...............................	0	385	667	922
+13347	PF13505	OMP_b-brl		Outer membrane protein beta-barrel domain	Bateman A	agb	Jackhmmer:B5ESE4	Domain	This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.63	0.71	-4.33	190	7576	2012-10-03 17:14:37	2010-11-10 14:45:20	1	53	2032	12	1809	11637	730	195.60	15	81.14	CHANGED	hshshhss.hu...ss..shu................ssp..........tsh.h...........l..s..s.u...h..shs......sh...s...................sss.......ss.s.t.......................s...s..sh..sltss.a...p...h....s....s......h......hu..l.ps.sh..s.............h......tss.....pttss.......................s.hp....hphht....................hsss......ht.h.p.....h.sh.....ss.............h..p....hYs......tsGhs.............................................hsp.p..hp...hts.................................ptstsp..huhsh..us..G......lpaph......s.....p.....ph....t.l.....ss..cY.p..h..t.ph.........................ss..............hcs.......ss...hpluluY+F	.........................................................................................................................................................h...hhhhh..hs....ss...shu....................................sts...........................th...h.........................l...s.......s.s....h...uhs............ph...p.............................................st..........t..p.s............................................s....hsh..sl...ths....Y.................p.....h..........s.......s.........h.........hu....l....ps..s.h..s.....................................h........tpt........pptss....................................................p..p.....ph.tt...............................................................ht..hp.............st.h.s........h...sh.......sph............hp......h.Ys.......tsGhu......................................................................................................hs.p.h.p..hp......t..............................................................spsps.p...hu.h....s.h........G.s......G.............lp.a.p.h......................s..............p..........sh......s..l............p.h...p..Y...p....h.....h.ph.........................................................ts.................hp.......ts.........h..hh..G..hsapF...........................................................................................................	0	544	1089	1459
+13348	PF13506	Glyco_transf_21		Glycosyl transferase family 21	Coggill P	pcc	Jackhmmer:B8IZF6	Domain	This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.97	0.71	-4.98	54	703	2012-10-03 05:28:31	2010-11-10 14:55:10	1	8	542	0	308	9471	1198	168.40	23	39.16	CHANGED	P...p..l..c....lhhs...ss....shuh.N..P...KlsNhhhshpt....Aca-hlllsDuslhlsschLpplssshpp...psGL.Vou.hsh.ssssp...u....hhutl.t.ssh...h.......s.sh.....thhhu....h...t.....uh..shshGtohhhR+psL-phGGhpulsphLAEDhthu.phlpst.Gh+ltlssts.ht.p.s.ss...tp.htt...hhsR.h..RWu+	..........................................................................................................................lhls..st....hus...N.s......Kls.N.Lh....hhct...........sc.....a......-......h.ll.l.s.Du.D.h.h.l......p...s...c....h...L.p...c..........l.s.......s..s..h.............s................-.............p...........l.....G.....l......V.........o.........s......h.....s..........h........s....t.....s.s..p........s..................h.h.u...t..l...t...tha..h........................s...h........sshhhs.............h...t.........................tt...t.h...s..h...G....t....s......h..........s......h..R......cs......s......L......c..............p......h..............G......G...........h......t.........s......h........t...........p...........t........L..........A.........-...D.a.hh...u.......phl......p.......s........t......G.......h.......+......h..h..h..u..s....s..hh..p.sss............phtp......hhp+....h...pWs........................................................................................................	0	96	178	246
+13349	PF13507	GATase_5		CobB/CobQ-like glutamine amidotransferase domain	Coggill P	pcc	Jackhmmer:B8IZF6	Domain	This family captures members that are not found in Pfam:PF00310, Pfam:PF07685 and Pfam:PF13230.	20.80	20.80	20.80	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.69	0.70	-5.48	255	4672	2012-10-03 00:28:14	2010-11-10 14:55:38	1	18	4440	7	1177	3706	2727	235.40	37	29.43	CHANGED	+P+VsIlpt.GsNschEhAtAFcpAGhcsh-.V..p.........h.s...-.........l.........h.........su.........ch.........s.Lcc..hphlshsGGFShGDsh.GuGcu..hApslhht.......plc-phppFh.s.R..DshsLGlCN.GhQhLspLu...Ll............Ps...............s...........cp.PphspNpSt+aEuRhspl..h....h.ss.p...S...Psl..hh.psh...s..shplP..V..uHGE..GRhhh.....spphhp..plhssstlAhpYVDs.......p..GpsTtp......YPhNPNGSstuIsGlsSsDGRlhuhMPHPERshcshpps.hs............t.t........t............ushhclFcNAhpah	...................................................+lAllt..GsNs-h-h..At.Ah....c.c.u.......G.......h.-.s...ht..Vh..........h...s.........l.........h.....ts.........ch...................s.L.ps..h...csllhsGGFSYGDhL...tuGt.h..hu.tphh........stltptlppah.p.c..ssh.sLGlCN.GhQhLs.chu...Ll................PG..................................shh+Npu........t+........F...u..+..hshl..h..............l........s...p......o........s...lhh....psh...p...thplP...VuHGE..G+ahs............ss.p...p.l....t..pLc.spsp....lsh+Ys-t....................s...t.......................hNPNGSspsIsGlss.psGp.VhuhMPHPERshcsl..s................................................hh.................................................	0	380	751	997
+13350	PF13508	Acetyltransf_7		Acetyltransferase (GNAT) domain	Bateman A	agb	Jackhmmer:B5FCA0	Domain	This domain catalyses N-acetyltransferase reactions.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.38	0.72	-3.82	163	13825	2012-10-02 22:59:21	2010-11-10 15:58:29	1	107	3917	33	2973	41376	6818	86.50	18	43.91	CHANGED	ppp..p.hhsh.pp...........ssc...ll.u...hh.tl.................tt....t........p...ht..........hlt.......tl..slpsphRspGhu...pp...llpt......h.......h...pph.....t...............t.....p...t...h.........h...........l............h............s.....p.......s.......p............t..........h.paYpphGFph	..................................................................................................t....hh.h.h...p..........................ps.p.....l.l...u....hh..pl.........................................................h......t..................p.....hh........................................hlt........tl.....s...V...p.s.php........u..p..G..l..G......pp....Ll.pp..........h..............t...pp.h...........t...............................................................t...........p....s.......l............h...................l...............t................................s........p........p.........p.............................s.............h..sF.Y..p.+.h.GFp............................................................	0	930	1796	2449
+13351	PF13509	S1_2		S1 domain	Bateman A	agb	Jackhmmer:B5FDY3	Domain	The S1 domain was originally identified as a repeat motif in the ribosomal S1 protein. It was later identified in a wide range of proteins. The S1 domain has an OB-fold structure. The S1 domain is involved in nucleic acid binding.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.56	0.72	-4.05	96	2158	2012-10-03 20:18:03	2010-11-10 16:15:05	1	7	1694	1	363	1496	70	60.30	29	26.77	CHANGED	lGphssLplh+ps.chGha.L.......s...ssp....s-lLLPpp..tl..s..cs..hplGDplcVFlYhDu-c..+llATsp	....................lGphthLpVlc..........p.......s.c.......h.Gha.L.................p....tst.......pslhLspp........Eh................pp....hplG-plpsFl.Y.h.Dpps.+lh.ATp..............	0	127	239	313
+13352	PF13510	Fer2_4		2Fe-2S iron-sulfur cluster binding domain	Coggill P	pcc	Jackhmmer:B8J1F8	Domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.66	0.72	-4.17	254	5655	2012-10-02 17:47:23	2010-11-10 16:31:22	1	204	3363	9	1816	5235	3983	79.40	31	11.18	CHANGED	sp.lshphDGpp.hpuhtG-TlAuALlusG................l.p.ls.+.oh.t......htpP...Ruhhsshups.ssLVpl....s.........u....ps...s.h.pAshs.lt-GhplpoQss	...........................................lplplDGp..p..l..p..s.....t.......G....s...ol..lpAs.tp.sG..........................l..p..lP..p..hCa....................p..............stl..s.s......s.G.sCRhCl.V..-.l.....c.........................s....t....t...l...t...uCsssl..p..-..GMhlpopp......................................................	0	630	1190	1513
+13353	PF13511	DUF4124		Domain of unknown function (DUF4124)	Bateman A	agb	Jackhmmer:B5FFC8	Domain	This presumed domain is found in a variety of bacterial proteins. It is found associated at the N-terminus associated with other domains such as the SLT domain and glutaredoxin domains in some proteins. The function of this domain is unknown, but it may have an Ig-like fold.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.29	0.72	-3.92	232	1444	2010-11-10 16:35:35	2010-11-10 16:35:35	1	18	588	0	495	1312	147	82.30	18	43.19	CHANGED	hhhhhh......ss...ss..s...u..u....plY+WsDps.GpspaoDp....Ps.t....s.s.ps.p..pl..........................phts.sss......................hs.t.....s.....ss.tts.......tpt	.......................h.hhhhh.....ss.....ss....s....u...u.........slYcasDss.Gsspao-p...........Pst.....s.s..pt..p..pl.............................................p...........................................................sttttttttttt.............................................................................................................................	0	129	310	423
+13354	PF13512	TPR_18		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:B8IZE5	Repeat	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.92	0.71	-4.16	19	80	2012-10-11 20:01:04	2010-11-10 16:50:44	1	7	80	0	30	1458	1509	130.10	30	50.38	CHANGED	sc-slP-hssuplYspAQcsLpsGsYpsAIcpLEuLDsRYPFGsYupQsQLDLIYAYYKss-hshuhAoIDRFlRLNPsHPNlDYVhYMRGLsshshDcs.h.phh.....phs.t.st..................tAFc...DFppLlp+YPsSpYAsDAppRh	..............................................p.s.splYspupp.tLpc.t.p.ac...pA...hpph.c.t..L.cs+..aP.h.u...au...p...Qsp..L...pL...h.Y..........u....a........a..cs...sc...h.......tAhu......sh-RFl.....+L.pPs.H........s.s.....l.....s.....Y.sh....Y.h....+GLsp..h...t.......s................................tsc+...D..p.sh............................................Aht..phppllppaPsotYu.cup........................................................................................	0	12	19	26
+13355	PF13513	HEAT_EZ		HEAT-like repeat	Coggill P	pcc	Jackhmmer:B8J2H7	Repeat	The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see Pfam:PF00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.	20.00	18.30	20.00	18.30	19.90	18.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.20	0.72	-3.35	261	1731	2012-10-11 20:01:04	2010-11-10 16:59:27	1	168	403	18	1145	5921	533	54.80	25	5.68	CHANGED	.plR......ptAhh.uL...s..........htt.t.ph...ht...hhtpllshLh.....hh..t....sss...tl..Rptu..shuLupl	.......................................................hR....cuAlh.ul......Gs...............lstsshpt.......hps......hls.pllshLl...........phL.pD.......sps.....tV..Rpsu...shsLup......................................	0	376	651	956
+13356	PF13514	AAA_27		AAA domain	Coggill P	pcc	Jackhmmer:B8J072	Domain	This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.	29.20	29.20	29.30	29.30	29.00	29.10	hmmbuild  -o /dev/null HMM SEED	1111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.09	0.70	-13.83	0.70	-6.88	10	1921	2012-10-05 12:31:09	2010-11-12 16:18:39	1	17	1239	0	319	1500	94	415.80	15	69.93	CHANGED	laGsNEAGKSTlRsAlpsLLFGFPtRoshs.FlHs+psL+lGGsLs....tcsGupLcFpRl++sst...oLhsscGc.sls--sLsshLsGhs+phF-ulFulDccsLhpGG+pIl-ApsclGphLFuAuAGlGS..LssVc-pL-cEt-pLaKPp.GppstINsulpphK-lppcl+chpl+scsWccppcsLccuccclppl+ccpcpL-pc+pclERlppltPhlp-c+uhpppLutl.uEslphPscus-Rhtphcschpsspppl-phpc+lpplcschsuIplDc-hLucAssl-uLpppcsphcpupp-lpphpuclsstcc-tsuLttQlG.Pshspsslcuhcsuhss+cplspLsp.......c+psLcptlcsApcpLcEpccclcplcpphsulssh..spsLhtul.ss.thhshtt...thtstcpcltps++cttpulspLG..attsl.t.hthslP.htplpthp+ctpEhtsstppt+cchpcsptpLtpl....tlptpthstssslsoss-ltssRstR-tlWps.................hs..tshs.th.chlppADpLsDphhspsppsupltplRpptEptptRhtthptchtshcpphAthctsWttthtshu.hPh.s.tth.sWltphpthh.t.pth.ptptEhp.hhptttchpttLtt.Lth.u.........t-LsthLptucphlcphc+sutccspL-c+hppscpuhpcAcc+ppcApcpl-sWcccWpphlhphtLsuphosstsls.ul-hhpchppchpcs-chsp.Rlpuhcc-lucFcpclcsLscshssth.s..s...pth+tLpsRLppA+-cupthc+LsEclcphccclspsspslpptptclssLhc....hApssohE-hhssscRu-ptcchccplscLppplsphssulsltuLttchsth-ssplpucl-plspcl-c.hpsphscLsppluctcsplupl-GsosAApltcchppthuplp-tAEcalpluhApplLppsh-RYR-s+psPlLp+AuEhFspLThGcFopLpsDs.-cpP.hLsucRssGpplpltpLSpGTRDQLYLALRlAsLEhhhtpppshPFllDDlFlsFDDsRocAslcsLc-Luc+sQVIaFTHHcHLlshstps.asspspllcL	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................................t....................h........hStush-.lhh.hRhu.h.ht..............................h.P....h.lh.DD.hh..D..Rht.hhthh...p........s.....t.....t..............Q.llhho....t..........................th......................................................................................................	0	119	219	276
+13357	PF13515	FUSC_2		Fusaric acid resistance protein-like	Coggill P	pcc	Jackhmmer:B8IZ01	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.84	0.71	-4.22	286	4566	2012-10-02 19:04:43	2010-11-12 16:27:32	1	34	2561	0	1051	5938	148	130.10	23	22.04	CHANGED	l..uh...hl..s.....t.h......h...s.h..........t.......+sh..........Ws.sls....shhlh.........p..s..s..hssshp+shpRhlGTllGs.hluhh..lh....h........hhs...s..s....h..h....hh......h..l....lhhh.....hhhh........h...h..........................h....s..ts......Y.....sh.ts..hh..l..T........hhsl....h.hhsh...............sssht.................hsh....RlhssllGsh....lulls	..........................................hhh..h..hl.s.p.h......hsh............t............+ua..........Wh.h.lo..s..hhl.h......................p..s...shssotpRhhpRllGTllGllluhs..ll........h.................................h.hs.......s..p..........hh....hl.............h.l.....hhhs........shh.h..........h...h...................................h....p....ts......Y.......uh..us.hh..lT.....hhsl........h....h.h.s.h......................ttshp.............................................hhhsRl.l-sllGshlAhh.s.................................................	0	275	612	877
+13358	PF13516	LRR_6		Leucine Rich repeat	Bateman A	agb	Jackhmmer:A5IFW6	Repeat	\N	23.00	8.70	23.00	8.70	22.90	8.60	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-7.04	0.75	-7.40	0.75	-3.27	889	30484	2012-10-02 21:32:02	2010-11-12 16:29:19	1	2898	807	67	21001	56590	2857	24.90	27	9.82	CHANGED	h.....ps..Lp.....pL.....s.....L....s........p..s.p.....l...ss...pu....h.......p....sl....u.............p	......................................pp..Lp........pL.........s...........L............u...............................p...N.p.........l.....sc......pG....s.......p..tls..............................................................	0	10309	14782	17695
+13359	PF13517	VCBS		Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Coggill P	pcc	Jackhmmer:B8J4T8	Repeat	This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.62	0.72	-3.61	1255	7532	2012-10-05 17:30:43	2010-11-12 16:50:10	1	572	812	12	4031	8611	7152	66.10	25	19.29	CHANGED	Dhss..DGthDll..s....s................s....s.....ss...................spl........h..h...t.p....s......s..G....s........hp............h...s.p......h........h..hss..s.................sts.h....s..........s....s....hu..DlssDGp.hDlls	.................................................DhssDG.h.Dlh..s..s............................s...s.....ss..................................stl.........a.h...s..p......u................s..G.......s..................as...............................t.h.....s.t........h.........thss.s...............................................stsh....u................s.....s.....hu...Dhss..DGp.hDlh.............................................	0	2314	3279	3827
+13360	PF13518	HTH_28		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:A5IDV5	Domain	This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.46	0.72	-3.92	193	5836	2012-10-04 14:01:12	2010-11-15 09:27:30	1	87	2346	0	976	15814	2048	50.90	20	29.02	CHANGED	p+hpl...l.ph.hh..p....s..p...shpp.....supphsl...sp.psl.tpWhppap.p.tG.h..s..uLt.s......c..p...p....psp	......................................+hpl....l.ph.hh..p.......u..p.....ohpp................hupcasl...sp.ssl.tpWl+tac.p..tG.....p..uL............................................................	0	285	617	813
+13361	PF13519	VWA_2		von Willebrand factor type A domain	Bateman A	agb	Jackhmmer:A5II27	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.30	0.71	-4.15	168	10039	2012-10-10 16:07:06	2010-11-15 09:44:16	1	392	2980	5	4071	16696	2611	193.40	16	32.32	CHANGED	slllllDhSsSM...........t..sp.....sh..........................................t.......s................Rlst.s.+tth.........tsl...lp..........p...h.........s.ss.....ph......u.l..lsau.........u.......s..............u.................h......h....h............h..................s........h....o...........s....-....t..ssl.....tsh.....l..ss......lssp.h..................................hs..s......s....u..........os....hs...t.ul.....................................tt..Ah....p.hh....................................p..p...t..s.............................tp...s.s.l.lllo..D.......G.....................ts.s..............sp..hh......p...............hh.p...........................................t..h...p..pp..s...hp.....l..hsl.........sl.G..........ss.......ps..s...............................................................t..s.................t..lpp.l..Ap..ts.....u......Gt.......hhph..psss..psls.............ph...hpp.h	...................................................................................................................................................................................................................................................lhlllDs.S.u.SM...................t.sp.................................................................................................................................................................................................................p..........+l..p....t....s....+p.sh...........................pp..h.....lp..........................................................p.......h................s..ss..........pl...........u...l......l..s....Fs................................................................s.......p....................u...............................................................p.........h........h..........h......................................................................................s.........h.........o....................s......s....t....pt.h...........tpt............l...ss.......lp.s...................................................................................s......s....s...................Ts..l.s....t....u..l.......................................................................................................................................pt....A.h.........p..h..l........................................................................................................................................p.....p...p...t................................................................t..tp.......p...h....l....l....ll....T....D........G.............................................................ps.s...........................st..h......p...........................hhp.................................................................................................................................................................t...h.......p.......pp...s.........lp...........l..hs.l..............sh..u.........s.s.....ts........................................................................................................................................................................................t............h.hpp..l....up.......s.......s..............Gt.........................h..h..h............................................................................................................................................................................................................................................................................................................	0	1621	2750	3486
+13362	PF13520	AA_permease_2		Amino acid permease	Bateman A	agb	Jackhmmer:A5ICF5	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.77	0.70	-5.94	61	23261	2012-10-03 01:44:59	2010-11-15 11:34:15	1	79	4110	20	6607	26829	2040	418.20	16	86.76	CHANGED	luhhsshhlsh.....us.h.....hu...ss......h..h.s...s...........hss....sGh.s..hhlhhh.lsshhh...hshthsh.hEl..u..s....hspsGGhhsas......pts....h...........s....phhu.....hhsshhh..hhshhh..sh.ss...h.s....sh.hhph.h..hth...h....t.................ph.t.t................................................................ph..hh.hhlu....lsllhhhhhlshhuh+hu.splp..h.hshhplh.hslhhhllhulhhh....tt....s..hhs.........................tp....s.................hhss.....shs......t.....h..........h...s...........u.h....hh......s..hauhsGa-ss...................sshspE...hp......p..+..s.h.huh......hhuhhhshllhhl..............hsls..hhh.lls..sp.l........s.t..ss..........................h.shhhpth.s...s.p..hhthlls.lhlsl......shhu....slhshhhuss+hltphuc-..........shlP.......chhsph.............s.c..hss........Phtulhhthlls.lhhhl.hh.........................................hh......tsshs................hlhslsshshh...lhhhlh.hhuhl...hh+...hp...p.....ph.......t+.................hh.h............h....h.lshhs.....hlhh..lhh....l.......hhsh...........hs........t.s.........s......stts...h.hhh.........hl.hhs.hh	.............................................................................shhshhhlsh....us.h........h.G....sG.......h...h..h.hs.................................h..hts......sGs...s.....s.lh..h......h....l.....l.s..sl.hh...........h...h...h..u.hs...a.....ucl...u.............s...t.......hP.....p..s......G...G..h..a.s..a.s...................pts..................h.......................................G.....p..h.hu.....................ah..s...u..a.h.h........hl.s.h...hh....s.s...s..s............h...s............hh....hs..s.h..h.......st.h.....h......s.........................th....t................................................................................sh....hh....hlh...s........................h.s.l...l..h...l.h......s.....h.l...s...h...h....G....s...c...h...s....up...l......s...sl....h....s.......h...........ht........l.......h.....s..l..h...h.h.l..l..h...u...h...h.h.h.............ph........s....hhs........................................................................................................ht..s....................................hhst..........shs..........s.......h.............................h.....s............................................u..h....sh.........s....ha...u.....a.h........G...h....-....s..h.................................................s...s...h..u...p-..........sc................p......+....s...hPp...u.l........................................l.h..u.h..h.l..s..s..l..l.....Y..h..l..............................................s..s...hs......h..h..s....h....l...s......pp..l...................s.t..s.ss..................................................................h..s.h.hh.p.h.h...t.................h..s.....hh.s....h..lls....h.s.s.h.l...............................uh.hu.........................sh.hs...h...h...h..s.............s...s..+...l.h.h.u..h..u.c..-........................................................u.h.hP...............ph.h...u...+..l...........................................................s...c...pt.s..............................P.h...t.......u....l...l..h....t.......s.l.l...s..h.lhh...h.h..h...........................................................h............tth.s..........................................hl..h....s.....h....s..s....h....s..hh............l...s.a..h..h.....s.....h.h....u...h..l..........h..l.p.......hp........t.........ph.........tp................................h.h...............................................................h....h...h.s...h..hs.................hlhs.....h..h..h....h....................h.h..h.......................................................................................hhhhhhhh...............................................................................................................................................	0	1861	3597	5318
+13363	PF13521	AAA_28		AAA domain	Bateman A	agb	Jackhmmer:A5IAR3	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-11.10	0.71	-4.28	115	1816	2012-10-05 12:31:09	2010-11-15 12:03:12	1	15	1500	1	435	2151	632	163.30	27	52.65	CHANGED	+lllsGu.usGKTT....Ll....ptL......u........p.p.........G.hs...hs..sEhuRpllppph.....spst.....thh......h..................-hhths.pthh.ptph.cp.h....p..s.s..........p.s...sphlFhDpuhh-shs.Y..h.chh.tt............................s....hss..p.....lt.p........tsp....ptc.Y...ch.lhlhs.s.hs.......l.....pDst.R..p.p.sh.cc.ttph.tpthtp....thpp....huh.phltl...p.ush.ccR	......................................lsIhGGtSoGKo.T....Ll....sp.L...................A..........p.h...................hs.ss..........ss...........E....h.....u........R.....c..hl.pph........stsp...............t.Lp........hp..................................................Dhht..hu.p........ttph..hs.h.......t.st.................h.u...spl.sFhDs...shl.s....s.p...u...a...s...cth..ts.............................................................c.....t.s..h..........lp.s..........hhp......ch+..a........Dl..Vlllp..s.ss............sa.........ssD.uh.R........s...t...s.......t....-.....cpph..pp....hlhc....hlpc........sh....phlpl...psshppR.............................................................................................................................	0	157	265	373
+13364	PF13522	GATase_6		Glutamine amidotransferase domain	Bateman A	agb	Jackhmmer:A5IAK2	Domain	This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes, such as asparagine synthetase and glutamine--fructose-6-phosphate transaminase.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.94	0.71	-4.20	67	6720	2012-10-03 21:14:07	2010-11-15 13:25:09	1	18	4568	0	1845	12173	7462	149.00	32	26.58	CHANGED	PDspGh..ah..ss......p.....................ssLuHs.RLull-hs.ttus.QPh...stssp....h...hlsaNG-lYNat....cl+ppLtt.tGhs..hps.poDoEVllt.hh....pphG........pcsl.p..........clsG.hFAhulaDp.pppplhls.RDch......G...hKPLaatht.........ssshhFASE	................................................................thttttth...............pG.....s.........................sGIG.HT...RWA....TH..GtP....s..p..t..N.A..HPH.............sssp.......................l.......slVH.NG.lIENat....................pL+....c....c....L.....t....s....p...Ghp..............F.pS...pTDTE....Vls+..Llt............................pphut................puhppsl..p........................................plcG.....ua.A.......h.....s.....l.....hs..t....p........s.......s..pllsA......p...........s.......sP..LllGhs.........pt...h..........................................................................................................	0	629	1210	1572
+13365	PF13523	Acetyltransf_8		Acetyltransferase (GNAT) domain	Bateman A	agb	Jackhmmer:A5IFT1	Domain	This domain catalyses N-acetyltransferase reactions.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.70	0.71	-4.33	54	3083	2012-10-02 22:59:21	2010-11-15 13:26:02	1	23	2166	17	599	11897	940	153.50	19	66.16	CHANGED	lRshc...ppD.hs.hlppWhsps+ls..ha.h.pp.st.sh.pth.cp.hhp.tlt...tssathshlu..........thsu...cPhu.........Yh.....Eh.....Y.spcc........h.....................ts.........p..s....tDpGhH..lLlu.ssc.h..hGtshspshhpulh...calF.t..-..tspRllsEPcscNpphhphhpphG.F.phhtph.c.h...P..cKcAt.Lh	...........................................................................................................................................pD.h...hh.....h.....p..h....h....p...p.....s...c..hh........h.....h.....t..t.....t.............t..................................t.t......h.....p......pl.............tp..p.p..h...t.....s.....h...l.s..............................h.h..c..s..........p..s..h.u.........................ah............ph...........h..h.s.p.ps.............h.....................................................ps..................p.s.....t.s...h...s...h..c.........h.h..h.....s...ssp..h.................t..G..c.Gl.u.pth.l......p...s.....lh..............ch.hh...p.....c.........t.........sp..c.lh.h-s..c..s...s....N....t.t....hh+....h.h.c..+.tG....F....ph..hup..h......h...s..t......h......................................	0	136	318	477
+13366	PF13524	Glyco_trans_1_2		Glycosyl transferases group 1	Coggill P	pcc	Jackhmmer:B8J2T1	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.83	0.72	-3.71	238	1210	2012-10-03 16:42:30	2010-11-15 13:26:32	1	65	678	0	497	17241	5704	98.20	19	21.71	CHANGED	l.sLN............hspp..............................ss.ss.....h.....RhFEshAsGs.hllos.............pslcp..h..FpsGp..................-..llhhp...shp-hhctl.cthh..p.ss.p.t.tp.pl.uptutpcl.hs.cH....Thpp...R..spplhs	........................................................................................................ts...s.....h.......Rh.FEsh.A.sGs..h..llo.s.t...........tsh..pp.....h...a..p...s...s.p..........................................c....ll..h.hp............shp....-.......l....h....c....tl....p....h....h..h.....p...s....s....p....p....t.....p..pl....u.....p.pu.h...p.p...l...hp...c.H..........o...a...p...p....R..hpph..t....................................................	0	190	360	424
+13367	PF13525	YfiO		Outer membrane lipoprotein	Coggill P	pcc	Jackhmmer:B8J028	Domain	This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.31	0.71	-4.85	30	2784	2012-10-11 20:01:04	2010-11-15 13:53:42	1	103	2215	4	696	2342	2289	181.20	26	61.86	CHANGED	s-hsspplYppAppuLppGsYtsAlcpLEsL-sR..YPFGsYupQuQL-LIYAaYKssDhstAhAsh-RFlRLpPpHPslDYshYMRGL.......oshpt..........tcsh..........c...RDs......sth.....+pAFp-FppLlp+aPsSpYAsDAppRhhaL+spLAcaELplAcaYh+RpAalAAlNRuphllcsYPsT.ustc.ALslhhpuYcpLuhsp.ttcpp.phL	.........................................................sspplY.spA...pp.t.l.p..s.G.s.a...ppAh.pthc.sl..p....sc.....a.Ph.u.s.aup.p.....u........p.l.......L......sa...A...a........Y..c...p........s...-.......hstA......hssh-+....F...l...c.ha..Ps..p........s...p......h.c..Ys...hY..hpGl............spht........................................spsh................................p..RD.....pts.....ptAhpshppll....ppYP...s..S..pY.s.s-App+.hh.hl.ps.....tLuth-...h..t..hu.ca.Yh.............p.p.............t...........t.....a.....h...........A.shtRhp...hhpp..a.ts.....h....c.ul.hh..sa..ht..t..........hh...................................................	0	207	426	568
+13368	PF13526	DUF4125		Protein of unknown function (DUF4125)	Coggill P	pcc	Jackhmmer:B8J0H5	Family	\N	25.00	25.00	60.40	59.80	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.18	0.71	-4.77	22	120	2010-11-15 16:02:55	2010-11-15 16:02:55	1	8	113	0	25	111	3	186.40	37	80.57	CHANGED	cppllcpIlchEWphFppspstuG+AsCQss.p.......sFclMRtSQahsWspphLpSYLpDLppActtGRNLlsEKYARMMphss.P....c..............s...........hpsh..ls...........cIsp...........h...........pht...........Wp+-htc+YPplspt..ts.hps...pD.......s...p.....sS....FETYLRuELtTYS.+TlpLYhphl..pchtppppNLscpshcphVphhGYcoL-cAEc	...............................t.cpllcpIlctEWs.FppspN.GGRAsCQssh........s.FplMRtSQahsaspplLpSYhpDLppActtGRNLlsEKYupMMp.os.P....c.a...........sts.hpshIp...........cIsp...........hplt...........Wtc-htc.......+...YPplupthRsltosEDs..tp...TShETYLRGELtTYSpcTlpLYtphl..tch..t..pp..phNLstphhtphsph.Gapsl--sEt......................	0	14	19	22
+13369	PF13527	Acetyltransf_9		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:B8J1N3	Domain	This domain catalyses N-acetyltransferase reactions.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.26	0.71	-4.28	105	3978	2012-10-02 22:59:21	2010-11-15 17:08:39	1	19	2411	47	796	9816	1092	126.00	21	48.77	CHANGED	clRtls.ps-..hcphhpLhphsFphspsth............p.h.phhpthhc......p...s...p.shshh-.....ssc....lluphthhshplsl..G.phhth.uulssVuohPpaRp....+Gl....hppLhpptLpphcpp.utsluhLhP...hp.h...shY.c+aG.aphs	....................................................................................................t..t-....ht.th....t....p..l....h...p......t....u......F.tsstps.......................................h..t.t.h.p....p..t..h.t..............................s........h...s.....h..s...s..h.c...............psp.............l..l..u..p..l...t.............h...............s..........h.......................h............p...........h.....p.......G.....p.....p......h...........p..........h.....h........s..........l..u...s.....l....u...V..t..Pc..a..+t........pGl....up.pL...l...p...ps....l.c...p....h....p.......c....t.....G.......h......s........h..s......h...l......h...u..........s...s.......s..a..Y..t+aG.ap...........................................	0	278	537	676
+13370	PF13528	Glyco_trans_1_3		Glycosyl transferase family 1	Coggill P	pcc	Jackhmmmer:B8J061	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.72	0.70	-5.24	39	1194	2012-10-03 16:42:30	2010-11-15 17:29:34	1	27	910	0	454	4822	1304	259.50	16	66.89	CHANGED	MKILYGVpG.o...GsGHlsRuRslsctL..+..p..H..-VchlhSG.Rs.t.chh...p..c.F..s.........hpph.........pGlohss.ppu...+lsh.........hcThhps.........thscthtphhp.hl..-hpp..hDLlIoD.FEPl..........o.u..hAA.....+hpslPsluluHQhAh...p.asls.ht....hss...hh...t+hhlpt...auPuphplulpaa........cap.ps.l.hPPllcpplhstp..s.t..p..t..st.lLVYLsh-shc.....pls-hLpt.hs....phpFhlY.Ghs.....p....-tp.......puslp......a+shocpsFhpDLtpCsuVlssuGFpL.uEALpLGK.lLhhPlc.G..QhEQp.NAhhLcpLGhGhs..h.sL-sshltcaLpph.......s	............................................................................................................................................................................................................................................................hh.h.h.h.p.s.....G...G.H....hsRsh.s.ls.p.t..L....p..t............h.........p.l..h...h..h.....s...s....t............phh......t....t...h..........................hh..th...............sh.............tt.t........p.hp................................t.t.h..h..............................t.........h..t.....t..........h.p..hl....pt.t......D.l..l.l.sD...h.....h.................h...h....hhs..............p..h........s.....h.....s....h..l.....h....l..s..p..........h........................................................................................................h...................................................h.....................................................................................h...h....................................................................................................................................l...h....h........hs.......t.t......................th.h.t.h....h...t....h..........................h....h.....h..h....t..............................................tplp......................hh...h....p..........t.h....p....h.....h.....t....t....s....p....h.........hlst.uGhp.....h...Ehhhhsh..h.l.h.h.P..h...........t....-...Q.....p.u.....h.t.th..uh..h.............................................................................................................................................................................................................	0	155	304	384
+13371	PF13529	Peptidase_C39_2		Peptidase_C39 like family	Coggill P	pcc	pdb_3erv	Domain	\N	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.15	0.71	-3.83	127	2151	2012-10-10 12:56:15	2010-11-15 17:30:24	1	145	1292	1	439	2081	233	142.70	20	40.19	CHANGED	lsVPhhtQh......s..p................h.sG..CtsToluMlL.....sah....Gh...s...hstsplApp..h.t..pss................t..tsahss.h.....ts....sh.ushs.tsl.tp.hup.pas........pshshsspsh......splh.ptlps..GpPVlshss..ht..................phsh.....ssHhlllsGYcp......st.......lhlsDPh	.............................................................................................................l.hhtQ........t....................................h.ps.CtssShsMlL..............pah.........Gh.........p............ls.t...t.p..l..sp.p..h.h..pts.................................................................hh.tp..............................t....ush.....ts...h...sp.hsp..pas....................................pshs..h..s.st.sh...................ps..l.t..ph.l.s.p.....G.p...PVlh.hh..s......t............................................t.h.st.....ssHhhl.lhG...Y-p................pt...........hhltDP............................................	0	190	306	388
+13372	PF13530	SCP2_2		Sterol carrier protein domain	Coggill P	pcc	Jackhmmer:B8J1N3	Domain	\N	25.00	25.00	25.20	25.30	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.20	0.70	-4.96	41	1071	2010-11-15 17:31:58	2010-11-15 17:31:58	1	4	843	39	229	841	26	209.70	22	53.40	CHANGED	spsGslsRsptWWcph.h.......t.........tttsc..h...p...hslahstsspspGYlhYchps..........sshpVp-hhussstAtpuLWpFlpuhpshhpplp.h.pp.ss--.sl.h..hLsD.P.cs.sp...........p..l..p..sahhsRllDltpsLpuh.sass...........stslsLpVp.Dshhsh.....NsGpapLph.ssGsssspps.........s...ps.s-lplslssLuslhLGspssspLsthGcl.c.....tps.sAlppl-p.lhss.c.p.Pah.-	.............................................................................................t..tGslhRsthhW...p.h.h.......t.........ttt.pp..h.....p.hslhhstst.cs...pG...Y..hh..Ypltp.............pphplpEh.hhhst.cA.ppuLap.Flsu..h.shlp...plp.h.ph.....sc....sL.h..hlp-..s.ch...pp............................p..h......p...shhMsR......IlD.VpthLp...th..sapt......................ptshslclp.Ds.hh.h.....NsGhaplsh...ts.......u......p.......sp.lsct.............................s........ts..sslplslpsLsslhhGhtp....sppLstht+l..p.......ssp..ptlpt.lcp..hhst.t...shh...............................................................	0	85	172	207
+13373	PF13531	SBP_bac_11		Bacterial extracellular solute-binding protein	Coggill P	pcc	Jackhmmer:B8IY91	Family	This family includes bacterial extracellular solute-binding proteins.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.52	0.70	-4.73	225	7719	2012-10-03 15:33:52	2010-11-16 11:58:06	1	25	3267	36	1791	14857	3154	235.70	22	78.01	CHANGED	lpl..hs..uuuh..ptshp.c.l.sstF.p.p......c....su........h.......p..l..plp....hu..so.....ut..lhp.....pl...........ppG..t..............s.....Dlhh.s..........us...phhpp.L.hpp......Ghst..............s.ttsh..sh..s.p....lslhs.tps.s................s.....................h....s.......h.p........s......h.p.s..........Ltp....s.............................sl.......+.....lu..husP....p.....s..sshGt............huh.phh..p...............ph..........................G..........................lhpplp.sp.hl...h..ssss....................pp.shph..........lt.p.G..p.....s.D...h.ul.s....h....to...ts.......................h...........ss..t.lph........l..l.Pssh...t................................h..thshulh..p....pu....tp........p...sA.psF....hpaL.tS.sp.upsl.h.pchGap	.........................................................................................................................................................................................................................................................l.s.sssh...pp...shp...p.l.s.pta.p.p.......c...ss...................lp..l....p.h.s......a.u....u.S......up......hs.p.......pl..............................tpG..t............A.................D.l.hh..s..................................As...t....p.t..h...s.t...l....t.cc........shlt......................................ss.sps.h......ht....s..s...........l.V......l...l...s..pcss................................s....................................................p......s.........l.p.........s..........h..sD.............Lhc....s.............................................sl.............c......ls......h.s...s...P......c............s....s..s.s.Gp...................hu.h..t.h.h.p...................p.h.........................................s.........................................................h..h........p..p..l.t...p.p....ls..........h.....s.s.ss......................................+s..shsh..................lp...p...G....p............u.D......l....h...l....s............a.........p.o....-u....................................h...............tss.....ph.c.l.................V.....h....s..p.....sh.......h.....................................................................sl.....p..h...s.....s....u....l.l...c..........ps.............tpp........p.tA...csa....lc.a.L.h.S.sp.u.p.p.l...h..tchta.....................................................................................................................................................................................................................................................................................	0	472	1088	1474
+13374	PF13532	2OG-FeII_Oxy_2		2OG-Fe(II) oxygenase superfamily	Bateman A	agb	Jackhmmer:A1B8L5	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.47	0.71	-4.48	71	3255	2012-10-10 13:59:34	2010-11-16 16:25:36	1	66	1836	23	1480	2897	465	187.80	22	55.86	CHANGED	G.hhhl.sal...s...t...p........p...hhphhpplh....p.pss....h.pp..th...t...Gpt.h...sl..........t.h....h....h....tthuW.........hs..........ct..t..sYcY....sstp......shsspsasshPthlhplhpchst.tt...................hs.s...hsP...sssLlNhYs.s..........uu.phGhHpDc-.Eh.....shssPllSlSLGssshF.........................................................ph....t..........................stp..css.....................spplhLpsGDlllhuGs..u..Rhta.Hulspltp.s.............................................t..................................ht.ssRlNLThR	..........................................................................................................h......................................ht.h.......t.............h..p....h...............h...................................................................................h.th........................hs..........................t....tY..pa......ss..h.................................p...st...s.h.s..s..h.P.t.....h.t.p.lh..pphtt.............................................................s..h.p.....s.ss..LlNhY.p..s....................Gs..pluhH..........p.Dpc..ch............sh.p.ssIs.S.lS.L......Gss.shF................................................................................................................ph......t........................................................................thp...pss....................................................hhplhLp.p.....Gsll.lh.sGp..s....phta..Hul..hpt.s...........................................................................................................................................................htstRlsLTFR..............................................................................	0	460	838	1193
+13375	PF13533	Biotin_lipoyl_2		Biotin-lipoyl like	Coggill P	pcc	Jackhmmer:B8IZB1	Domain	\N	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.24	0.72	-4.30	99	2242	2012-10-02 20:27:15	2010-11-16 16:33:40	1	39	1526	0	592	25272	6066	54.60	29	15.15	CHANGED	ps..........lsl.s.spl..uG.tlspl......hVp.-sp.hV+cG-lLhpl-s.sphp........hthpp...............sps..p.......l..t	...............................p.....tl.s.ssl......uG..hl.spl....................................Vc..-..s.Q..hV+KGpl.L.h.p.l.Dp...schp.....................ttlpp............................sptt...................................................................................	0	178	334	468
+13376	PF13534	Fer4_17		4Fe-4S dicluster domain	Coggill P	pcc	Jackhmmer:B8J3I4	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.76	0.72	-3.62	126	4064	2012-10-03 08:56:43	2010-11-16 16:34:27	1	53	2739	54	1193	12425	4526	71.60	29	15.95	CHANGED	tChpC..s..h..Css....................Cs......h..............hhh...........hs.t.......t..........sp......p..hhpph.....th..............s....hh.p.p.......h..t.t........p......t.h...ppCstCGh..Cp..htCPt..sls	.............................................pClhC.u..t........Css..........s.............CP.....o....................................ahh.....................ss.c..........c...................................ss.......s..l.h.t.t.h...phh.............................................ts..ph.p..t...........h..pp..t.................h........pl....pC...tsshs.........Cs..psCPpGls.................................	0	417	815	1025
+13377	PF13535	ATP-grasp_4		ATP-grasp domain	Coggill P	pcc	Jackhmmer:B8J4T0	Domain	This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.16	0.71	-4.55	109	4886	2012-10-10 13:17:03	2010-11-17 14:52:06	1	70	2718	6	1546	35532	13206	172.70	17	35.99	CHANGED	th+.cKhth+phhp.ttGls.sst.......thhlpshsshpthhpth........h....PhllKPtpu.su.....S...hslhh...lp...sts-lpsh..hpphttph.................tthllEpals............G...s.asl-uhhh....cGch.hhhsstchhhs.s.ph.....h.hsth....tt.......tthpphspph..lpsh.uhp..pGshHhEhhhssc.G....hhhlElss.Rs.uGsth	.......................................................................................h..psKhhhp.c....hhp...p....t..G..l.s...sst.......................................t.t..h...h......s......s......h........p.......p.....h.......t.....p.....h......h...p.p.hs.............................h...........P...l.l.lK.......P......t....s......u...su...................u...........tu.l...hh.................lp...............s.t.p..-....l...p...p.h.....hp..p.hh.tttt........................................................................thl..lE.c.a.ls..............................................G.......pp...h.......s....h........p....s......h..........s...........sG.........c..........h.........h........h........h........s......h.....t.......p..........h........h....h....t.............................h........................h.s................................................ttl.h..p.h.s....t....t.h.........h.p...t...h....s.h....................u...h...h...p...h...-..h..h.....h.........s........t.......p....s.....................h.h.h..Ehs..R....t............................................................................................................................	0	543	1039	1334
+13378	PF13536	EmrE		Multidrug resistance efflux transporter	Coggill P	pcc	Jackhmmer:B8J0H9	Family	This is a membrane protein family acting as a multidrug resistance efflux transporter.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.59	0.71	-3.88	52	1585	2012-10-02 19:55:49	2010-11-17 16:30:08	1	10	1267	0	447	11223	5450	114.20	18	37.49	CHANGED	AulR...ah..hhhhhhhlllh...h...+t..p...lt..........p....h.hp..th+p...pshh......h....hlhhuhlGhslh...hshhshusph.....u......s.u.hls.s...h.ht..h..sslhsslluhhhh....p.....p...chst+............tllhs.hllhsGl..hllthpp.h.tu...hs	..................................................................h..hp.h.h...h...h..h.h..h.h..h..h..h........h.....pt......p.....h.t..............................t....l....hp......t..h.pp.......p..hh....................h......h..l..h..h..u..h..l.s.h.........ht.....hhhh..h.hA.hth....u...........s..u...hlu...sh.ht..l..ssl.h.ssLluhhhh.............+.........c............+.ls.h.t..................................................ph..l.u.s.hl.hh.h..Gl.hh.hth.......tt..................................	0	132	261	374
+13379	PF13537	GATase_7		Glutamine amidotransferase domain	Coggill P	pcc	Jackhmmer:Q2LTR9	Domain	This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes such as asparagine synthetase and glutamine-fructose-6-phosphate transaminase.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.39	568	6228	2012-10-03 21:14:07	2010-11-17 16:30:36	1	28	3641	10	1948	11436	7426	122.40	33	21.85	CHANGED	HpRLul..........ssGpQPhh........t.ssp...hs..llaNGEIYNa....p-LRp.-Lt..s.t..G.....a...p..F..p.o.p.SDTEV.lhthhtt.................aGpssl.......p+LsGMFAFAla..D....p..c..pp....pLhlARDRhGlKPLYYsh........p.......ut....sl....hFuSElKALls	.....................................................................tRLul....ss..tt..u.tQPhh....t...............t.st..p..........hsls.......aNGE.......lY.........Nh..........ppLR...p...cLt.....p..p......G.................h......t...F......p.....o......s......S.....D......o.EV....l.l.thhpc...............................................ts....t..csl....................cc..l.........p..G..h..FA.F.s..l.h.D...........p.c.pt......tl.h...h.uR.D.hGl.+.PLahup..................pp........ss.....sh......hhuSEhpAL....................................................................	0	640	1243	1641
+13380	PF13538	UvrD_C_2		UvrD-like helicase C-terminal domain	Coggill P	pcc	Jackhmmer:B8J482	Domain	This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.48	0.72	-3.89	132	6202	2012-10-05 12:31:09	2010-11-17 16:43:43	1	104	3952	12	1430	12988	3540	110.90	23	15.99	CHANGED	hths-thlhhhsshpp....................tlhsspltph...tpht.........pttttlpt............................................hsasholH+upGuEassVhlstsstt...ht..........htpch....LYTAlTRApptlhll	..........................................................................................................................h...uc.lh.hhNs.th...................................slhNG..slGhh..h.t.h......t...................................t.t..h.ht...................................................t......p...........................hphuaAhTl.HKuQG.SEFst..Vl.l...hh..ssth..........................................................hhp+pL.........lY...TAlTRA+cpLhl.............................	0	456	937	1217
+13381	PF13539	Peptidase_M15_4		D-alanyl-D-alanine carboxypeptidase	Coggill P	pcc	Jackhmmer:B8J0M5	Family	This family resembles VanY, Pfam:PF02557, which is part of the peptidase M15 family.	25.00	25.00	25.10	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.91	0.72	-3.53	215	1064	2012-10-02 01:02:30	2010-11-18 11:18:06	1	38	858	0	257	963	223	71.80	28	28.71	CHANGED	su.sst..hSpHs..........aGhAl......D..ls........shh.hstp......................................................................thstspp..ls..p.hhtp.........hG....tWGGc.W...............h..h..Dh.HFph	........................................................tts....tp..pStHh..........h..GhAlDls.......t..s.hlt.h.ssp...............................t..............................hphst.h.pp..hs..p..hhpp......hG..h..p....WGGc.W..............................p.....sh...hDt.HFph..................................	0	109	185	224
+13382	PF13540	RCC1_2		Regulator of chromosome condensation (RCC1) repeat	Coggill P	pcc	Jackhmmer:B8J0U2	Repeat	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.26	0.72	-4.24	320	3569	2012-10-05 17:30:43	2010-11-18 13:23:35	1	413	646	32	2155	12729	3878	29.90	34	6.54	CHANGED	l..s..p....lu...s..G.t.tH.....shu.Lp.s....s.Gs.......lhsaG..s..N..s..tGQ	.......................hht.lu...s.....G..t..tH....................ohu.Lp.s.......s.Gp..................lhsaG.....p...N....p...hGQ...........	0	959	1559	1984
+13383	PF13541	ChlI		Subunit ChlI of Mg-chelatase	Coggill P	pcc	Jackhmmer:Q2LRR9	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.31	0.71	-4.59	173	7224	2012-10-03 01:04:38	2010-11-18 16:46:55	1	17	4260	0	1657	8626	2674	111.30	31	23.71	CHANGED	VEVcl..u...sG.L...Ps...aslVGLP-sAV.KES+...-RV+oAlpN......oGacaPsp+ITlNLAPADL+K-GutaDLPIAlG..IL......u..u.....p...t.p...h..s..t..h...........p..p...hh...h..lGELuL-GpLRslpGsLPhsl....tA.p.ctu.h.+p.lllPtpN	........................................................................................................................................................t................sGh...t.......h.......s.......s.....p.....c.....l...h.............lN......l..s...........s.u....s.......l...+.hs.....tsuhDLulAlAll.......ou.....h..p..p....h..s..hs....................p..p..hhhlGEluLsGclR.....sVsu.s.pplt....EA.t.....+....h..G....a.c.p...hllPptN........................	0	556	1110	1418
+13384	PF13542	HTH_Tnp_ISL3		Helix-turn-helix domain of transposase family ISL3	Coggill P	pcc	Jackhmmer:Q2LSW8	Domain	\N	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.06	0.72	-4.77	134	3356	2012-10-04 14:01:12	2010-11-18 17:14:59	1	11	862	0	381	2084	96	51.40	41	17.15	CHANGED	tpss.hlpctsphTpthcp...hlhphhtpp...ohpslActhsluhpTVpclhpchs	..................A-Ts.lV+KNpQIschlsQ...KIAQpLlE+..hSMT-IA+pLulSTSTVhRhLsca.p...............	0	89	236	288
+13385	PF13543	KSR1-SAM		SAM like domain present in kinase suppressor RAS 1	Page R	kellrott	NMR Structure	Family	\N	27.00	27.00	28.00	27.60	26.20	25.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.65	0.71	-4.35	10	142	2012-10-02 20:42:54	2010-11-20 00:12:54	1	6	79	0	70	133	0	111.40	45	15.00	CHANGED	hshlQcMIDISus+LcGLRTQCAs.Ss-LTQQEIRsLEuKLV+aFSc.LlsKp+lsEc.s...AstL.sY.....PcLpQWLcVVGLpscolpulhsplpTL-shLcMs-cEl+plLsc...spsp.EEEp+RLppAhpNLR	.................lQphI-lShspLpG.LRTpCuh.....S...ssLTQpEIRsLEuKLV+YhucQL.sKh+.ls.p.....sstL.sa............PpLppWLclVslp.-slptl...........s.p...h..oL-sLLchs-tcl+phlpc.....husp..pEEstRLstALpsLR...........................	0	18	24	45
+13386	PF13544	N_methyl_2		Type IV pilin N-term methylation site GFxxxE	Coggill P	pcc	Jackhmmer:Q2LVK2	Motif	This short sequence motif appears a the N-terminus of type IV prokaryotic filamentous adhesins or pilins. The N-terminal residue, which is methylated, is hydrophobic (generally a phenylalanine or a methionine), and this leader peptide is hydrophilic. The fifth residue of the mature sequence is a glutamate which seems to be required for the methylation step.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.49	0.73	-7.55	0.73	-4.25	777	9430	2012-10-03 10:38:27	2010-11-22 10:00:16	1	25	2209	25	2394	7502	2666	27.30	43	14.94	CHANGED	M...............h.ppppGFTLlElllulslhull	....................h.................ppppGFTLlElhlVlsIlulL.........	0	899	1563	2033
+13387	PF13545	HTH_Crp_2		Crp-like helix-turn-helix domain	Bateman A	agb	Jackhmmer:A1B3V6	Domain	This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.15	0.72	-4.19	94	8343	2012-10-04 14:01:12	2010-11-22 11:39:05	1	18	3028	101	2466	7943	935	72.00	22	30.98	CHANGED	pR.lApaLlthtschst....................hpls.lopptlAphlGl.pR.ps.lopslppLpppGlIp......h.....p+.s.plplhDhptLpph	.................................................RlsphL..l.t.h..s.pp.hst........................................t.......hpls...loppcl...Aph...lGs.o+.po.lsRhLpchpcc.G.lI.p.......h................pp...p.pl.tl.hchptLtt.h......................	0	769	1663	2072
+13388	PF13546	DDE_5		DDE superfamily endonuclease	Bateman A	agb	Jackhmmer:C0W963	Domain	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.69	0.70	-5.54	14	1337	2012-10-03 01:22:09	2010-11-22 13:29:01	1	10	331	0	429	1483	75	212.80	20	63.11	CHANGED	sLpphhspassh....Fspt..cpppthhthltGhlushpR+ol.tluh..hhutpssp....uhpchlspsca-tsplpttltp.shsph....sssptllslDsTshsKp.....Gp+osuVtRpasGshG..Ktpss.sslalh.sspth.pshlstplalP.ptWhps......t.+pphsslsss.hapsK.plAtthlcphhtsu.h.hth..lssDutYu.tcttFlptLpptt.hthlsplpsspshahtsst.ts.......pGRPthhs.h.....hslpssplh....phhspsapphsh+ttsKG.	..................................................................................................h....................h.t...........t..t.h..hh....s.....hh......tp.+s.h..hut......h....ht..t.t.t.....shpph.lspsp...as.t.t.lht...tlht.h..h...h.............ttttt.h....hhlD-osh...Kp......G..h..po.s....sl.s.+...p..a..ssph.G......+.......h....t....p.s.....hs....l....h....hs.......st........t....p...h.l..shp..l.h.h.P...t..thhtt...........................cp.pts...th....p...p.....h..h...t....s..K......t.....lsh.t...lpp.h..ht......t..h..t.h...lluD..uhYu....pt..th...h...t...h.pp..h...s...h.....hhhtlp.psphh..h............................................................................................................t..............................................................................................................	0	104	270	331
+13389	PF13547	GTA_TIM		GTA TIM-barrel-like domain	Bateman A	agb	Jackhmmer:A1B6L4	Domain	This domain is found in the gene transfer agent protein.  An unusual system of genetic exchange exists in the purple nonsulfur bacterium Rhodobacter capsulatus. DNA transmission is mediated by a small bacteriophage-like particle called the gene transfer agent (GTA) that transfers random 4.5-kb segments of the producing cell's genome to recipient cells, where allelic replacement occurs [1]. The genes involved in this process appear to be found widely in bacteria [2]. According to the SUPERFAMILY database this domain has a TIM barrel fold.	27.00	27.00	27.00	27.10	25.80	26.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.00	0.70	-5.43	66	218	2010-11-22 15:16:03	2010-11-22 15:16:03	1	5	195	0	83	214	30	265.80	48	25.22	CHANGED	WuYRRFILHYAtLst...u.....AGG.V-uFlIGSEh+GLTplR............suss..uFPAVstLtsLAu-VRulL..........Gsss+loYAADWSEYaGapss-GsG-haFHLDPLWAcssIDFlGIDsYhPLoDWR-GpsHhDAt.......................thsulaDhsYLpuNlpGGEGYDWaYsos.........tsRsAQhRoPITDushuc.......PWlaRhKDl+sWWsNsH...a...-RsGGVctusPTuWlPpSKPIWFTEhGCsAVDKGsNQPNlFlDPKSSEStlPhaS..........sGtRDDhhQppaLcAhlsaWs......s......sspNPsSslYG....GtMlD.schalWsWDARPaPtFP	..........uYRRFILHhApLsh...t.......AGG..V.DAFlIGSEh+GLTplR............ssts..saPhVstLpsLAu-lRulL..........G.sss+loYAADWSEYauapstsGsG-hhFpLDPLWAcssIDhIGIDsYhPLoDWRDustp.ss........................thts.aDh.shLptsltuGEGa.DWYYsos................tsRtAphRsPITDGhhuc.......PWlaRhKDl+sWWsN.Ha......sRhsGlc.us...........sTuWlPpSKPlWFTEhGCPAVDKGsNQPNlF.DPKSSEsthPhaS..........sGtRsDhhQcpaLcAhhpaWp......s...pNPhSs.lYG....G.Ml-.pchalWsWDARPaPtFP.............................................	0	18	58	68
+13390	PF13548	DUF4126		Domain of unknown function (DUF4126)	Coggill P	pcc	Jackhmmer:Q2LV71	Domain	\N	27.00	27.00	27.30	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-10.88	0.71	-4.84	52	380	2010-11-22 16:08:38	2010-11-22 16:08:38	1	3	355	0	157	366	68	174.00	31	86.32	CHANGED	slhLuhGLuhAuGlplYlslLhlGl.hut.hGh..lsLPss...h...phLssshslsssulhhllEhhADKIPsVDslhDslpThlRhsAGuhL.sAu..sh....uc...hsP..sh..........p..hshAslhGGuhAussHus+uusRsslNsostsluNslsSssEDssslsh.hlAlhhPllhlll...ll.......lh...l...lhsh..hhlh+lh	......s.lhluhGLuhAuGlRl.a.lslLhhGl.hut..hGh.........l.p.LPss...h........p.hLssshVlsshulhslsEhhADKlPhlDohhDslpThlRhsAGAlluAu...sh.......up.....hsshh.............t..h.hAslsGGsh.Asss+hs+u.usRshlssostshuNh..lsShsEDshsluhhhlAhhhPllhhll.hl.......hh....l.......hhsh.hhh.p..h.......................................................	0	44	105	139
+13391	PF13549	ATP-grasp_5		ATP-grasp domain	Coggill P	pcc	Jackhmmer:Q2LV27	Domain	This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.14	0.70	-5.13	220	2119	2012-10-10 13:17:03	2010-11-22 16:09:47	1	27	1555	1	765	4111	1934	216.30	36	28.42	CHANGED	pAlsc..u..Rsh.LsphEuptlLsAYGIsss.tohl...Ap.ospEAsthAppl...G.aP.VslKlhS.....Pc...Is.........H.........KoDlG...GVtLsLp.ssppVcpAhpplhppl..ppth.........P.s..........................Ap.l.pGlh..VQpM...sp......tupElllGsspDPhFGPllhFGh.GGshVElhpDt.........uhsLP.P..........Lsh.slAcc.h.l.pps+st.plLp.G..hRs..p.P...sD.........hsALtphLl+l....SpLls.....D.h.Pc........ItElDINPLls....ss....p........G..shAlDARltl	..................................................tt.tt...Ls..ptEsp.s.lLpuYG...lssh.sshl............As.ss.sEAlp..hAc.pl..........G..a.P.....V.s.lKlhS..........Pc.......Is.........H.......................KS.-...l.s.....GV.hL.......s..Lp...sspc.Vp...p.Ah.ps.l...h...s....p....s....phh.h........P.p.......................................Ap....l..c....G.lL....V.Q.pM.....ss.........sutE..Lhlu..l..p..c.D..P...s...F..G..P..l..l..h.h..G.....GGl.h.s-.h.h..c.Ds............s.h.t.L.s.P............Lsh....s...A.c...t....h...l....pp..l..+..st.......c.....l...l..t..u.....h+.sp...s....lD................l.s.u.LsplL.l.p.l....Sp.Lls.......-.t..P-...........I..p..c..lDINPLl..s..ss.......s.........t....hsAlDspl..........................................................................................................	0	255	518	663
+13392	PF13550	Phage-tail_3		Putative phage tail protein	Bateman A	agb	Jackhmmer:A1B6L4	Domain	This putative domain is found in the large gene transfer agent protein. These produce defective phage like particles. This domain is similar to other phage-tail protein families.	21.80	21.80	21.80	22.00	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.60	0.71	-4.47	106	1924	2012-10-01 22:58:23	2010-11-22 16:42:01	1	32	968	0	203	1978	371	159.10	38	15.89	CHANGED	sp..pss+sslpsLhpsashsshpps.uplph.htc..s...................s.ps.s..hsl.stsslstssp..t.........t......hphs....Rssps....-hssplplpah-ss...ssYpsss...sp.utp......s...s....sts.....tthsshphshshs.....pspApplupphLtpstsspcs.hpasls.pt.ht......lp..PGDllp.ls...s.................s...p....st..thRlspl...c....p	....................................................................pppcAa-VLsDhsushR.shs..lWsG.p...s...Lsh..lpD..t...................s.-h...V...asa..spusVVhs-p.t...............FcYo...ho.uh.+....DR.asuVcVsa.....hDPs.....Nuapsus.......EhVcD.........s...p......ultR..............hGcNhtch-A.aG.CTS........RGQA+....RsGhWllcTphhEspT.VsFolGhcG.lp......hs..P.GDlIc.lsDst..............huG..h....thuGRlhul..s.....................................	1	37	114	158
+13393	PF13551	HTH_29		Winged helix-turn helix	Coggill P	pcc	Jackhmmer:Q2LS51	Domain	This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.55	0.71	-3.92	85	3523	2012-10-04 14:01:12	2010-11-22 16:50:17	1	49	1390	0	1218	5925	803	103.40	18	36.88	CHANGED	RtpslhhhspGh......tssphuchhul.sppslh+hhcpap.ptG...hsu...Lhs...ptp..tspspp....lsstpcp....tllp.hsp.ppssp....G........shhohphltp.l...........hshplStpslpphlp+.tu	...........................................hlhh.h.tp.uh...........hpph..uchls..l...upp.ol.h+ah......p.p.ap..ptG.........hpu.................Lhs......pt+......ss.p.spp......hstp...hpp..........tl.h.p..hhp.pps.t.....s...................ph.o.h..p.hl..tp.h.....................s..h.t..l..u.....ps..l.tphhht.............................................................................	0	289	753	1056
+13394	PF13552	DUF4127		Protein of unknown function (DUF4127)	Bateman A	agb	Jackhmmer:C0WER5	Family	This family of uncharacterised bacterial proteins are about 500 amino acids in length.	27.00	27.00	46.40	46.20	17.60	17.30	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.60	0.70	-6.10	50	186	2010-11-22 16:53:42	2010-11-22 16:53:42	1	4	127	0	59	185	2	426.60	27	92.87	CHANGED	+llalPLDsRPsshpash.luphs.shpllsPPpchLushppsucs-tLtpWLppp.s..ss-shllSlDtLlYGGLlsSRppphshcpshpRLphL+pl+ppsPshpIYAFslIhRsst.s..sspp-PtYa...tpYGtplaphuh.......hhD+.t....hs.ppttph..tplpttlPtchlpDahs+RpcNhplNtthlcLsc.cGllcaLslspDDss.auhsshEpcpLtphhpphsl.tp+...............lhhaPGADElGhsLluRshsphtt.p....PplhlhYsssputphls.YEspslpcolpp+lpuuGuhhsss.ppADhlLhVsssstttt......tt...........pshpphsppIpphlsp.GcsVulADlAasNGuDppLlphL.tctshltcLtuYuGWNTuuNolGoulApuhlthth...............stpsphphLhtRhl-DahYQusVRsplp..cphtt.....shshhslscpptt.............hpphhpp.......hhpphhtpphshphhthph..............phPWsRhFElslpl	..................llalPlDsRPsshphsh.huphs.shpllsP....Ppphluth..........pps.............ussptlhpWl.pp.ht.pscshllShDhLlYGGLlsSRhpph........s.pph..........t+h.phlcpl+ptpsph.lYsFshlhRs...s..s....sst.-s...aa.tas...tlh.phuh.......l.c+.t.....t.ht.t-ttph...ttlpttlP..phlpcaht+RppNhtlNpthlp.hsp..pGhhshL..slspDDss..hu.ssh-...tptLtthhpp......ht....pc................hhhhsGADEluhhLlsRhhsch...t.h....PplhlhYs.stutthls.YEs.t...sltpolptpltusGuhhsp..tpuDh.lLhlpss.......................................................tshtthsptlpphltp.sh.lulsDlu...hsNG...u-ttLhthL..pts....h.......l.cltuYuGWNTsuNolGhslupuhlhhhh........................s.ttphphLh.chl-Dah...Ypu.lRpplt.pth.t......t.s.hth.t.pttt.t.............hpthhpp......................................hpphhtt....hh...h........h..ph.......................phPWpRhFEhphp.........................................................................	0	21	38	55
+13395	PF13553	FIIND		Function to find	Weichenberger CX, D'Osualdo A	kellrott	Joint Center of Structural Genomics (JCSG)	Family	The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal)\	  [1]. NLRP1 is a member of the Nod-like receptor (NLR) protein  superfamily and is involved in apoptosis and inflammation. To date,  it is the only NLR protein known to have a FIIND domain. The FIIND\	domain is also present in the CARD8 protein where, like in NLRP1,  it is followed by a C-terminal CARD domain. Both proteins are described\	    to form an "inflammasome", a macro-molecular complex able to process  caspase 1 and activate pro-IL1beta [2]. The FIIND domain is present\	in only a very small subset of the kingdom of life, comprising  primates, rodents (mouse, rat), carnivores (dog) and a few more,\	 such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein  failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR) [3].  Upon discovery of CARD8 it was noted that the N-terminal region  shared significant sequence identity with an undescribed region in  NLRP1 [1]. Before getting its final name, FIIND [4], this domain  was termed NALP1-associated domain (NAD) [5].	27.00	27.00	28.40	28.10	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.61	0.70	-4.95	7	140	2010-11-22 18:21:59	2010-11-22 18:21:59	1	31	32	0	69	160	0	224.30	41	24.92	CHANGED	RV+hPsAGoYphPsTGLtFlVpcsVTl-IcFCu..WsQaLc.ch..pcsWhVuGPLFDIKAEP.GAVsulaLPHFluLpsGcVDs.ShFpVAHFK-cGMlLEpPsRVE.aasVLEsPSFSPhGlLLRhlsushh.lPlTSssLlYa+l.a.E-lsFHLYLlPsDsslpKAIDDc..EhKFpFVRIpKPPPlssL..hGuRYlVSGS..spLEIhPcELELsYRSPGE.QlFSEhYlGphtssI+Lplp-K+atsLVWcALlKPsDL	......................................................................VphPsAGpYphssTGLtFVVppsVTlcIpFss..Wspa.Ls.ch...ppsWhVuGPLFDIpA.Es..sAVsslaLPHFlsL.p.s..u.cVDs.ShFpVAHFp-cG.MlLEpPu+VcsaasVL-sPSFS.hGlLL.+.hhpushh.lPlsShsLlY.a+h.......p.--l..p.hHLYLlPsDsslpKAID-c.......E.+F.phl+lppsPPhp.s.L..hGs.cYhVSss.......t.lc.lhP.p.E.Lc..LsY+Sstc.QhFochahtphtp.IpLplppp.....pp.sllWcs.l+ss........................................................	0	20	29	43
+13396	PF13554	DUF4128		Bacteriophage related domain of unknown function	Wahab A, Serrano P, Geralt M, Wuthrich K	kellrott	Bordetella bronchiseptica RB50 PDB:2L25	Family	The three-dimesnional structure of NP_888769.1 (PDB:2L25) reveals\	     a tail terminator protein gpU fold, which suggests that    the protein could have a bacteriophage origin.	27.00	27.00	27.00	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.35	0.71	-4.47	28	150	2010-11-22 18:52:35	2010-11-22 18:52:35	1	2	141	1	34	122	78	121.30	22	89.05	CHANGED	tIppulct+lsphs...tt...sl.lAa.NlsFssssut....sYLpsthhPusTpshsLutct.phhpGlhQlsVlhPsGpGsstspplAspltstFtsspplppsshtlhlppsPphussIssssphplPVolpY	................Ipthl.s+ls.s.hs.....tht..shs.lsa.Ns...s...........Fssssst....halphphhsusotshslu..t..ss...h..hhp..GlhplslhsPsGsGssthppl.AcpLtphFp.....th...s.....h.t..........t..............h.hshph......................................	0	3	18	26
+13397	PF13555	AAA_29		P-loop containing region of AAA domain	Coggill P	pcc	Jackhmmer:C2M2Q6	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.25	0.72	-4.44	68	804	2012-10-05 12:31:09	2010-11-23 10:58:31	1	6	755	0	192	5015	2079	55.80	31	5.90	CHANGED	LpclpllNWGoFcs.cshs..ls.tG...s..sLloGssGSGKSTllDAlpslL..sPsp..t.h..tFNpA.A.sss	......................................apt...p.hs.....h...s...p...t..G.......h...hlIoGs.oGoGKSTllDAlp.hh..L....hsps.................t.........................	0	60	123	166
+13398	PF13556	HTH_30		PucR C-terminal helix-turn-helix domain	Bateman A	agb	Jackhmmer:D3Q4F0	Domain	This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.48	0.72	-4.38	456	5435	2012-10-04 14:01:12	2010-11-23 15:02:24	1	29	2226	4	1399	4584	150	58.40	30	14.07	CHANGED	L.lcTLcsal.pss.tshspsAppLalHpNTlpYRLc+lpclhG.hc.lp...s.sps....th.pLtlAlpl	..........................LhcTLpsa..h..pps..sshspsAcpLalH+NTlpYRL..c+lpcls..G.hs.lp....s..hcs....th...lhlAl..........................	0	544	1037	1249
+13399	PF13557	Phenol_MetA_deg		Putative MetA-pathway of phenol degradation	Coggill P	pcc	Jackhmmer:Q2LTI1	Family	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.95	0.70	-4.57	154	1206	2012-10-03 17:14:37	2010-11-23 16:08:22	1	10	655	0	439	1221	272	237.20	14	76.57	CHANGED	uspssssp.....Gppls........shchph...pssh.phhhhp.s.p....h.hss..thuhthh..l.s.hh...phph.phs......t..........hpss..t.....G.huDhhlushhhhatp.t..........shph.......shthtlthPsGsasts.ps......s...........shhshssphuhs...hs.s.thslssshthsh...tscsss....................phptt.sthphshshsh..t...h.st.....ph.ssGltua.hh..............t..s..........ts..sctpshslGsulsahhsts....hplshphtpph....sspsthtussh.hh+h	..............................................................................................................thth..........h...th.h...............tt.....phsh.phh....l....hh.......phph..ths........t...........................................http..ts................G.hGDltlushhhhhptst...................shth..............................shthtlphP.T..Gshsts.p...........................ut................shash.ssthuhs......ht.......s.....ths.lssph.thth..............ttcsss.....................phptu.st.h...phshshsa.......t.l..ss..........ph..ph...ulssh...hh.........s..................p..s.t...........ss....sctpsht..lss..uhtathstt..........hplphphhhsh........sspsh..t..h.........................................................................................................	0	137	262	362
+13400	PF13558	SbcCD_C		Putative exonuclease SbcCD, C subunit	Coggill P	pcc	Jackhmmer:C2M2Q6	Domain	Possible exonuclease SbcCD, C subunit, on AAA proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.25	0.72	-4.07	152	3904	2012-10-05 12:31:09	2010-11-23 16:14:37	1	21	2832	14	954	3276	186	85.50	31	7.53	CHANGED	pphhDhRsa.hs.aplphp....pts.........u.ppht...h...hpshsshSGGEpthhhhlsLtAAluthh..st...........tss......hchlhLDEAFuphDscphppshp.hhpp	........................................h...........t.hplph.......p..................s...tp......h..........h+pstsLSGGEs.................hhsuLsLu..LuLushh..pp............shs.................hchLFLDEuFusLDs-olcssh-sLc.t..........................	0	313	591	808
+13401	PF13559	DUF4129		Domain of unknown function (DUF4129)	Bateman A	agb	Jackhmmer:D3PZP2	Domain	This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.43	0.72	-4.01	194	1189	2010-11-23 16:26:06	2010-11-23 16:26:06	1	12	838	0	462	1144	159	72.80	18	14.34	CHANGED	ptapthhp.hhtpt.ulspp...s...upTspEh....spcs....sttt.........t..lpp..........lsphacps+Y.....Gscs.sstp.ph......pphtpthcpl	..........................hatthhc.hhtph.ulshp........sucTspEh...spcs..............................spths.........ssshpp................lsphappspY............upps..sstt..ph.........pphhphht...............................	0	148	321	418
+13402	PF13560	HTH_31		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:D3Q8V6	Domain	This domain is a helix-turn-helix domain that probably binds to DNA.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.90	0.72	-3.77	149	10133	2012-10-04 14:01:12	2010-11-23 16:28:26	1	174	2365	13	3830	31197	3989	66.80	24	29.09	CHANGED	pLGttL+p.hRp..ps..........................G.l.otp.plApths........h.Sts...plsclEp...Gcp...s.........shs....hlptls.ch.hs..s..s...........ss.....th.p..tL	........................................................................................hGttlRp.hR.p....p.t...........................G..l..opp...pl.A.p.t.sG................l..S....h.s.....hl.sp.lEp.......Gc.p.....s..............................oh.p..........hlt..t...ls....ps.Lt....l..s.......................hh...........................................................................	0	1127	2704	3367
+13403	PF13561	adh_short_C2		Enoyl-(Acyl carrier protein) reductase	Coggill P	pcc	Jackhmmer:C2M4X7	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.50	0.70	-4.60	47	22490	2012-10-10 17:06:42	2010-11-23 16:43:09	1	80	4615	768	7643	72809	33208	228.60	25	81.38	CHANGED	Gshs-pSIuWtlActht-pGApllloshs......................t...............................hh...stlp.plucph..s.....sc.....l.......l..shDss..st..-c...................lpplhpplpcph.......GplDhllHSIuhusp.t...htpshh-.s.shctahpuhslSuhSahslhpthh...hhscs......GSlluLoYlAupRs.hPsYs.sMusAKAuLEShsRsh.AhchGc.+slRVNsIStuPht.TpA.upuIss........h-p......hhpaupphuPLsp..s.su--lAsssshLhS-LsptlTu.pslalD..GGhs	...........................................................................................................................................................................us.....pGIG.h..u.h.A.....p...t...h...s....p.....t....G.....A...p......l...s...h...s...h.s.t.......................p................................................................................t..........t........h...p.....p...h.....h...p....p...h...s...............tp..........s..........................h..ts..D..l..s....st...pp.......................................................l..p..p...h...h..p...p....h...h...p..p.h.............................G..p..l...D..h....l.....V......s...........s.......A.....G............h............s...............................................s...s....h........h.............c............h.......s..............t...........c........t.............a.........p.............p...............s........h.....s.......l..........s...........l.......h..............u............h.....h.......h.....h....s.....p....t....s.hs..............hh.....p...p...s.................................G..u........I......l........s.......l.........o............S..........h...........s...........u............h............p............s..........h...........s..........s...........h..........s.........s...............Y.......u......s.........u......K.......A.......A......l.......t.............u.........h............s...+........s....l....A...h....-....h...........u.........s.................p.........G.....I.....R...V..N......u.....l.......u.........P.......G.........s..........l..........p......T..........s........h........h.....p....s.....h....h..t..................................h.p.p....................h...h...p.....t....h......t.......p..........p.......s.........P...........l.............t........R......h...........u......p.......s.........c.....-..l.......A..s..s...s.h..F...L.s.S....-.t.u..u....a...l.T.G.p...s.l.hV..D..GGh.......................................................................................................................................................	0	2101	4453	6315
+13404	PF13562	NTP_transf_4		Sugar nucleotidyl transferase	Coggill P	pcc	Jackhmmer:C2M1K0	Domain	This is a probable sugar nucleotidyl transferase family.	27.00	27.00	32.60	31.80	22.90	24.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.88	0.71	-4.58	35	114	2010-11-23 16:46:08	2010-11-23 16:46:08	1	3	114	0	61	123	80	160.00	28	39.69	CHANGED	phlLF--st.tppLhPhTaTRPVu-lRlGIhTl+EKWpphL.s.......ssp.s.ohhsccYL........pp+aP........sph.p.t-...s..........lhlNuphlPsc.tlsphIps..L....c.Gp..ul.hps-.....cllAhc....................h..cp.....schs.............sh.................ttlp....htpshhhlcpsWDlFshNsptlppDach.lo..p.GRsS	.....phlLFDsss.tppLhPhTaTRPVu-lRlGIhTl+EKWpphL.s.......s.ssohlTcsYL........ppKaPh.............sp..t..tp...s..........lhlNushlP.sp..tlhphlpp......L....p.sp...Alhts-........pllAhhhp...............tpp.ss.hs..............ph.................phlp....htpshhhlcpsWDlFshNsptlptDaph.lTpsR..............................	0	29	48	58
+13405	PF13563	2_5_RNA_ligase2		2'-5' RNA ligase superfamily	Bateman A	agb	Jackhmmer:D3Q0T5	Family	This family contains proteins related to Pfam:PF02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.15	0.71	-4.50	139	2076	2012-10-03 21:31:48	2010-11-24 11:46:27	1	31	1509	1	702	2552	184	152.70	17	68.99	CHANGED	sssshttt..lppl+.................thhstt...htths......sHlTLhhshhssp...........................spltptlpphht....................................................phps...Fp.lpl..sshstF.........tst.slalps.........................pstppltpL+pplhps......h.th...h..tt.............................tsapPHlT.....lupthsstsh...................................ptlhptl.......................tth.shp....hpls..plsLhphpsss	...........................................................................h..............h.........htt........HlT.L..th.h..t.c.h.s.pt..........................spltp.t.l.pph.ht....................................................ph.t...s........hp....l.pl....sth.us.Ft...........tss..sla.htl..........................................tssspLtpLpp.....plppt......htth........sh....................................psatPHlT.....lAp.t..h.s.spph...............................tphht.l........................t......hp......h....lp..phtLh......t...............................................................................	0	219	478	611
+13406	PF13564	DoxX_2		DoxX-like family	Bateman A	agb	Jackhmmer:D3Q9W4	Family	This family of uncharacterised proteins are related to DoxX Pfam:PF07681.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.47	0.72	-4.05	115	1334	2012-10-02 13:32:46	2010-11-24 11:51:27	1	7	742	0	518	1577	778	103.00	19	78.74	CHANGED	llsslluhhhhh.uush.+l.h...ps......t..h.....h.....t.....shs.........p.h..G...a..P.tth.hhh.lGshclhGuluLl.....l.s..h.h....h..s...hls.hAAsGlshhhlGAhhsH..l..pts-s..t......t.....hshsl..shh.sl..shus	.............................hthlluhhh.hh.suhh.+l....h...ts................p..h.......h.....p.....ths.................p.h..G.....h....P...th..h....h..h..h..l..G..s....h..ElhuuluLlh.s....h...............hlshhA.uhhl.s.hh......h.l.u....A.h.h.s.H.....h.....tstc.....h............t...........hhhsh..hhh.hh....h.........................................	0	202	354	442
+13407	PF13565	HTH_32		Homeodomain-like domain	Coggill P	pcc	Jackhmmer:C2M820	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-10.26	0.72	-3.18	486	664	2012-10-04 14:01:12	2010-11-24 14:43:25	1	19	411	0	337	3654	468	74.30	20	27.49	CHANGED	Tl...t+aht+...a....pp...tG....ts...........t....tp....sups.....hp......sph..ptlhphht.....pp.................hospplsph.ltp....t............hS.tsolt.R.hL	................................................................oh.+Whp+..a..............pp....tG....tul.s...................h..t.tc....sG+s......pp......hssch..ptlhph.hp.....pps.....................phoscplspp.Ltp......th.h........ShsTlh.+hL........................................	0	104	210	313
+13408	PF13566	DUF4130		Domain of unknown function (DUF4130	Coggill P	pcc	Jackhmmer:C2M6X4	Domain	\N	27.00	27.00	27.70	28.50	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.07	0.71	-4.68	156	594	2010-11-24 15:37:12	2010-11-24 15:37:12	1	4	583	0	199	587	26	164.90	28	52.22	CHANGED	cpsp+hshlachlhhsh.phsp..plhpthucssVhp.ltphs+pVp+EtH+hcuFlRFpcl....ps.........shahAhhEPcaslLshlusHFscRassppWhIhD.c+thusha...cs..pph.phh....s.hs........p.....th...........ph...........s.ppEctappLW+sYacolsI.tRhN.+....hppppMPp+YWKtLsE	...................................t...p+hshlachlhps..h.p..tsp...plhpphuDs..sVhp......lpphsKpVp+EtH+hc.u.F.lRFpch...ts....................shahAhhEPcaslLshhusHFtcRassppWhIhD.p+thuh..ha..-s....pp.lphh....p.hs........s....t.........t...ph...........................s.ppEctappLW+sYapsltl.tRhN.+....hhpppMPp+YW+.LsE..................	0	59	132	167
+13409	PF13567	DUF4131		Domain of unknown function (DUF4131)	Coggill P	pcc	Jackhmmer:C2M1S0	Domain	This domain is frequently found to the N-terminus of the Competence domain, Pfam:PF03772.	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.92	0.71	-4.86	202	2454	2010-11-24 15:48:31	2010-11-24 15:48:31	1	9	2425	0	598	2213	149	162.40	14	22.34	CHANGED	lhGl....lhs.........hh.hhshhhhhlhhhhhhhhhh...hhh..........................................t.thth.........hhhhhhhhhhsshhhthtthphtt......pphsphht................tpthh.....lpG.hl.....tstPphp........spth.....pahlphp............htsttpt.hss+lhlth.ppptt...............hphG..-tlpl...puplptPpsstNP..utFDYppYL.tppsI..huphhspshphh	.......................................................................................................h....................h.....hhh...h.h.h..hhhhhhhh.hh.......................................................................................hh.....................hhhhhh.h.hh.h.hh.h.h..h...t..h..t..t..thtt.........pths.t.ht...........................h.........hps..hl................ss.h......p.hs........................................spth.........phhht.........................................tstpth.h.hcl.h..l.t..hptpt...................................hpsG...pphph...pu...c..lc.sputtN...........uuFD..hp..t..ah.ht.pslhthh.ht.....h....................................	0	189	382	494
+13410	PF13568	OMP_b-brl_2		Outer membrane protein beta-barrel domain	Coggill P	pcc	Jackhmmer:C2M356	Domain	This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.24	0.71	-4.47	110	1717	2012-10-03 17:14:37	2010-11-24 16:11:55	1	14	223	0	538	2059	496	183.40	15	70.26	CHANGED	tAQ......p..................hp..hGhpsG..h..s.h.....sshph..................p...t...p........ph...sh.............ps.uhs..sGh..hs.chth...s..p....t....h..u....l..p..stltasppshph..ptp.....................t...........p...............ttphphphshlpl.Plh..h...paph...sp..........hphtlhsGsthuhhls.ppt.........p...tt...............t...............................t.ph...s..t....tph...pp..hshulthG..huhp....h..h...........p....hh...l...phcapa.GLsshhp	....................................................................................t..........................hphuhpsG..h..s..h.......ssht...........................................p...................p...sh..................ph....uhp....hGh...hs..ch.th.........s..p.....p......h...u....lp.....sslh..as.pp.u.h.ph.ptp.......................................p.......................................................ttphph.p..hs.al.p.l...Plh...h...paph....sp...............hphhltuG.s.hh.uhhls.sph.....................p.......hp.............t.........................................................tph..s...p......tph...p.p....hsh..u..l..s..hG....hGhp....h..t..................p.......hh.......l..phpaph..Ghss..................................................................................................	0	277	479	526
+13411	PF13569	DUF4132		Domain of unknown function (DUF4132)	Coggill P	pcc	Jackhmmer:C2M366	Domain	This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.	27.00	27.00	37.40	37.40	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.03	0.71	-4.75	83	961	2010-11-24 17:18:36	2010-11-24 17:18:36	1	16	526	0	149	754	8	181.60	41	17.24	CHANGED	G.KplKolPtsh+c-........tshpc....hpsh+K...plcphhstptpRLEpuhhss+pWssppa.pp.hhs.HPlhpplsccLlW...h......sss.......t.tshthh...cD..ss.........lsshcscth......p.Lsss.s.t....lpl..sHPlclst.tslssWpchht-hclhQPFcQltRc..lahlTss.Eps..tspspRau.Gthlps.t.ph.hu.hlpp+GWp	............................spRhKslP+.ptsDDp...pAs-AlschKtLKK...Dscplupp...plsRLEsAhpppRRWShtsFpthhVpHPlsRhlTpRLIW.GlY.....s.pp....................pLlssFRVA....p-..ss....................assAp.D-.h......s.LPss.s.......IGI..sHsLElos...pp......tutFuQlFADYElhPPF+QL...sR..p..o.ahLTt...........s..Eps..usp..LsRWtG+.psss.Gpl.hG..hpt+GW...................................	0	46	88	102
+13412	PF13570	PQQ_3	YWTD;	PQQ-like domain	Coggill P, Eberhardt R	pcc	Jackhmmer:C2M3Z1	Repeat	\N	22.00	18.00	22.00	18.00	21.90	17.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-8.19	0.72	-3.55	1244	1943	2012-10-05 17:30:43	2010-11-24 18:25:17	1	236	866	9	946	6594	2060	41.50	27	13.21	CHANGED	G.phh.....Wph...........ph...s..s...th.h...sss....................sh..s.....s...s....h.....lalsst...............suplh.u.l..-....sp..s	............................................Gphh..Wph.........................ps.......s......u.......ts.h.....usP........................sl...u.........s....G..............h.........Valsot............................sGplh.A.l..st..........................	0	381	735	860
+13413	PF13571	DUF4133		Domain of unknown function (DUF4133)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0094	Family	Based on Bacteroides thetaiotaomicron gene BT_0094, a putative uncharacterized protein as seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or vs when in culture [1][2].	25.20	25.20	25.30	26.00	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.08	0.72	-3.76	26	267	2010-11-24 18:36:44	2010-11-24 18:36:44	1	1	110	0	31	216	10	94.30	60	85.71	CHANGED	INKGIG+sVEFKGLKuQYLFlFAGGLLAlFllaVlLYMsGVsQalCluFGssouolLVWtTF+LNpKYGEHGLMKhhAt+pHPRYllsR+plh+Lh	..INKGIGRsVEFKG.LKA.QYLFlFAGGLLAlFlLh.VILY.MsG.lsQalCIuFGssuuolLVWtTFpLNt+YGpHGLMKhuAt+pHPRYllNR.+plh+Lh.......................	0	11	29	31
+13414	PF13572	DUF4134		Domain of unknown function (DUF4134)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0095	Family	Based on Bacteroides thetaiotaomicron gene BT_0095, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or vs when in culture [1][2].	22.30	22.30	22.40	22.40	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.11	0.72	-3.88	27	454	2010-11-24 19:06:34	2010-11-24 19:06:34	1	3	132	0	47	312	15	94.60	48	88.66	CHANGED	pKthlhshhhlhshss..thApssuuuGhst...Ass.lsoYhsssspLhYAIuAVlullGulpVY.KhssGDpDlsKshhuhhGAClFLlssupll.uFF	......................p..thhh.hhhhhhsssu...sshAQG....sG.AGIsc......ATphVoSYFDPuTKLhYAIGAVVGLIGGlKVYsKaooGD.sDsoKoAuSWFGACIFLIVAATlL+SFF.......	0	16	42	47
+13415	PF13573	SprB	PbH1;	SprB repeat	Coggill P, Eberhardt R	pcc	Jackhmmer:C2M2H5	Repeat	This repeat occurs several times in SprB, a cell surface protein involved in gliding motility in the bacterium Flavobacterium johnsoniae [1]	26.00	20.00	26.00	20.00	25.80	19.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.70	0.72	-4.35	113	1000	2012-10-03 16:25:20	2010-11-25 11:10:41	1	88	62	0	782	1180	555	36.20	31	8.65	CHANGED	stssssloCtG....sssGolsl.ss.oGG....o..ssYoYp.Wssuss	......................ssso.C.u...........sss.G.s..l...s.l...s...s...o...G.G............o.....us....Y.oYs.assst...............	0	535	718	782
+13416	PF13574	Reprolysin_2		Metallo-peptidase family M12B Reprolysin-like	Coggill P	pcc	Jackhmmer:C2M7W3	Domain	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.58	0.71	-4.21	49	431	2012-10-03 04:41:15	2010-11-25 14:00:08	1	33	240	11	189	3218	220	181.20	21	27.86	CHANGED	hspshsthssshsplNtlYE.............c.-hu..lph.....sL.l..s.............s.spll.hhssso.....csass...............................sssshhspt.pshhssh.lGpp........sYDlGalh..ssh..ssuts...GluhlG..................slCs..ss.......pps..............oG........hs...........sPhGssh.........thch...lAHEhGHpFGusHohs...............s.ssp..t....o.u..ss..........EsuuGsoIM.u.Yu.....uh...sssp..............sl.s.p	...................................................................................................................................p....................................................................................................................................................................................................................ht..........tt.t.....................sh.s...h.....s.hlh..............tsh......ss.....u....sh..............Gl.Aalu..........................................ulCp..ps........pth....................................s.G............hs............pshssth.................uh.tT...huHEl..G...........HshGusHsss......................................................s..p.sp....s.....s..s..ts...................ps.tp.G....s.h.IM..s..ht..........sp....s.s..p.........F..S.s..o.ht.h......t..............................................................................	0	79	103	149
+13417	PF13575	DUF4135		Domain of unknown function (DUF4135)	Bateman A	agb	Jackhmmer:D3Q4V7	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 380 amino acids in length. The family is found in association with Pfam:PF05147. This domain may be involved in synthesis of a lantibiotic compound.	27.00	27.00	27.50	37.00	26.20	25.70	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.23	0.70	-5.46	79	396	2010-11-26 09:48:42	2010-11-26 09:48:42	1	9	292	0	97	356	22	354.20	24	39.27	CHANGED	YPVLsRhlspphpp.ahptht-lhp+lt.pD...................hppltpp....hhtsp.......sp..lsslph..u.h.uDsHssG+sVhhl..pFs....sG..h+lVYKPRs.Lpl-ttap..........phhpalspp....s..t....h..h.hh.chls.ct.....YGWtEalptpsCp................spp-lpcaYpRhGhlLulhalLsuoDhHaENlIA.......t.hPlllDlETl..h........p..s.........................p.h.....t...s....s...s..h.s.tp.t..p.......................ulhpsG...ll..s.t............h.h.....h.....s..s....t.p..u....................h..sls.hh..s.s......s...ps..hp...h.......hp........t......h..s......h.t...pts..........scsh....lttt.ttph.......................t...ss..tsYh.......ppllpGFppsY.phl..hpp.+p..c.l...hp...hlhp...FpssplRhlhRsTphYuplLp....tuhHPc.....h....hps.cpphhh.phh.......htpp.tttplltsEhpsLhpsDIPhFtsps	................................................YPhLh+hlspthtphhphhhcllppltpD...................hstlppp.............h.htp.........sp..lsslph.s..h....GDsHstG+oVhhlpFs.......su....+llYKP+slthcpthp...................................................plhphlspp....s..t.....hp..lhh.......chls....pss..............YuatEalpttssp............................................stcclpcaYh+hGhLlulhallsuoDlHaENlIu......pGphPllIDhETlhp..s.............t..h.......s....s.s..t...stt..t.t.t..................lhpSVhpoGlLPh.......h...h....t...p...pp..u..............hDlSuh.ut....p....ts.....pp...sh.p..h.h.l..hs.t......oDph....ht.ht.phph...tt.................hpsp.l...phtpYh..pplhpGFpphaphh..hp.p..+p..c.h.....hp...hl.tt...htshpsRhlhRsTphYuplLph.thcPs...........hh...pst..hcccthhpplh..............ttp.pppt.llttEhppLhptDIPhFhsp.s.........................................................................................	0	31	58	86
+13418	PF13576	Pentapeptide_3		Pentapeptide repeats (9 copies)	Bateman A	agb	Jackhmmer:D3PTZ3	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.28	0.72	-4.07	230	524	2012-10-03 04:02:01	2010-11-26 10:13:22	1	41	195	8	233	1940	556	48.40	27	19.80	CHANGED	FspspF.pss...sFp....pspFpsss....p....Fsp.spF....s.pspFpsspFp..ts..ssFppsp	.....................................................................................................FptspF.pss.s.sFp..........pupFpsss....s.......Fpp.upF.....ts.sssFssupFp....ts..ssFtts.......................................................................	0	69	184	226
+13419	PF13577	SnoaL_4		SnoaL-like domain	Bateman A	agb	Jackhmmer:D3Q8I0	Domain	This family contains a large number of proteins that share the SnoaL fold.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.66	0.71	-4.22	175	2151	2012-10-03 02:27:24	2010-11-26 11:07:17	1	22	700	23	793	3721	973	126.70	18	73.54	CHANGED	ppLpscpsIppLhscYstthD..........p...........t..ch........c....th.s.s.lF..sp..D..uthchs...sh..............s..........h.hpG.........t..s..........slhshhps..................h.h..s........shh...........hs...........tH..hhs.s.hl.p.l....c...........G........D..p..Apupsh.hh.......shh.hh.s.s...................s.s.......s.ht..hh..hs.......u.tYp..cchh+p.............su..t......W+lpcpp	...............................................................stttIpp.lhsc.Ysts.hD...............p.............p..ch........c....th.ss.lF...ss.....D..u.h.h.phss.........................t.............hhpG..................t.s.......................slhs.h.hpp.........................................h..h...s.....thh.........................hs...........................tH....hhs..s.h.h.l..p..l......s...................u............-....p..A..p.upsh...h..h...sh.h..hh.ss.................................t.t...........t..t..hh...ts..........utYp....-p...h.h+p.............ss.t......W+ltph................................................................................................	0	154	493	664
+13420	PF13578	Methyltransf_24		Methyltransferase domain	Bateman A	agb	Jackhmmer:D3Q0B1	Domain	This family appears to be a methyltransferase domain.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.37	0.72	-3.21	204	1368	2012-10-10 17:06:42	2010-11-26 12:36:09	1	67	883	14	614	4985	3811	113.70	21	37.53	CHANGED	lElGshpGtSshhlsps...h........pp..s..sh...........................................pl..h..........ulDh.......t........................................p.......htt..hhp......................................p......................tthss.......h..........sphh.........tsss....................tp........s.ht........pht.........................s..s...l.D...........llalDG...sH...s...h..........p...s...sht-..h...pth...h..s..t.l.p.s.s..u.....lllhcDh	.........................................................................................................lElGs.hGh...Sshhhst.s...h....pp..ss...............................................pl..h..slDh......t.t.....................................................p......htt..hhp.............................p............................ts.h.s.s.....h...............lpl.h..........puss......................p........s.ls.....pht.......................................s..s.l..D.....................ll.a.l.DG......s.H...t.....h......................p.....sshts....h......phh........h....s.......p..l.p.s.G..u.....lllhcDh..................................................	0	222	417	536
+13421	PF13579	Glyco_trans_4_4		Glycosyl transferase 4-like domain	Bateman A	agb	Jackhmmer:D3Q529	Domain	\N	27.60	27.60	27.60	27.60	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.16	0.71	-4.09	231	11449	2012-10-03 16:42:30	2010-11-26 14:14:27	1	99	3251	7	4057	16665	3336	167.30	15	40.28	CHANGED	GGhtphs.tplup.sLs...p...t.G..h..c....Vp..l...l..s..............s.s....tss...........................t.............ht.......t..s.........s....s.t....l.h..........t.l......s......hs.........tt..................t............t.......t.............h.t.........h.h.......................h....t.l.................tp....h..................l..................t.....................ttpsD....ll.a....s.p..s...h..h......s...s....hhs....h...h.u..........t...t.......t..s.......hP...h........lh...sh...........................+...............................s........hh........ht............t............tsh.........tt...p......h..h......t.......h.h.....pc......hhhpp..As...t......llsso.ptht..pt..lt.p.h..u....h..sss.clhllssu	...............................................................................................................................................................................Ghthh.h..hpl.sp...tLt.....t..........t...G.....h.....c...........Vp...l...h.s.............................t......t.t...................................................................t.............................s............s.....h..p........lh.......................p..h................s.............h...........................tt.........................t..................h.t.........t...........................h.t...........h.h..............................................................................t....t..l....................................................tp....h.......................................l....................p...............................................................................................................................................ptpsD.......ll..a......s...p......s.....h..h....................s..s........h.su.......h.....h.s........................t........t................................h...s.................................hP...h........V...h...sh................................................................................................H........................................................................................s.........hh...............hp........tt...................sh......................h.t...p................h...h...........t..................hh.........pc.....................t.h.h..pp.........s..c.....t........lls..sS..pt.h.......t........pp...hh..p..h......s.....h.......t....t.p.h.hl....................................................................................................................................................................................................	0	1455	2852	3553
+13422	PF13580	SIS_2		SIS domain	Bateman A	agb	Jackhmmer:D3Q8F5	Domain	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.44	0.71	-4.46	65	4732	2012-10-02 15:05:26	2010-11-26 15:23:47	1	23	2778	42	921	4439	1821	135.90	30	60.55	CHANGED	pYhsph.ppllppl..pp........ptssIppAuchlspul..pssuhlalaGs.GHSthhApEhhhRsG....Gl.sshpslhh.slhLps...s..s.....t.tustlE+h..puhucp.lhpt..ht....l..pssDllllh.SsSGpN......sssl-hAhtA...+cpGhplIAlTo	..................................................................................t......................p.t.................ttI...p.pAuphlspuh..psG.G+llhsGN.G.s....S....u....ss.A.....chAsEhs..........sp...a.p.p....p..R....s.l.s.u...l....u....lss........s.s.............hloslus-hthc............p...l...a...u+....p....l...puh...................u...ptG.DVL.lu.I.SoSGsS.........ssllpAlctA...+pp..GhpsluLTG...............................	0	327	600	773
+13423	PF13581	HATPase_c_2		Histidine kinase-like ATPase domain	Bateman A	agb	Jackhmmer:D3Q5R6	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.69	0.71	-4.34	142	5237	2012-10-11 19:05:54	2010-11-26 17:53:18	1	183	1833	0	1838	7481	882	122.50	20	41.79	CHANGED	hsuphp.pltt.lpphlpph.h..tt.tslstptht........clpLAlsEAhsNslpHuhtpts.t...............t.l.................plp....................hthpspt....lpl..p........lpD.pGts.hsst.th..s.....................................sstttuGhGlhllpplhDpl..ph.............sss...Gsplphph	.......................................................................................................................................t..hth..s..Rthh.tth..h......tp......hs......h.....s........p...t..hp.................................s.l..p.l....s....l.....oE.hs........o....NAlpH.u.....h..t....t.....................................t.l..............................................plp.......................................h.t.h.p.s.sp........lpl...p.......................VpD...p.....Gss....hsht...ph...t...................................................................................sttppsGh.GLh..l.lp.p.l.s..-.....ph.....ph...............tst....Gpplhh....................................................................	0	613	1434	1724
+13424	PF13582	Reprolysin_3		Metallo-peptidase family M12B Reprolysin-like	Coggill P	pcc	manual	Domain	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.01	0.71	-3.60	94	288	2012-10-03 04:41:15	2010-11-29 11:26:57	1	38	237	4	116	3927	262	129.40	19	22.22	CHANGED	huthssslspsNtlac..p-hu....lphpLl....slhh......hsss.......s.s.....shss..sss..................tthls.pt...tsh.hss........t.htpsshDl.uplhss......................usuGlAhl..........ushsssspp..............t.uhss.ss..s.st.h.h................shhuHElGHphGusHo	...................................................................................................................................h...h.t.hshss.h..hp......p.s................lphpls.............th.h..............h.pht.................s...t........shhp..pst..............................................tp.hls..sh....ssh...pth......................t....p.p.ss....s...D.h.sh.h.hpthsh...................................ptssGl....Aal........................uuh.shspts.....................................t.shsh...sp......hst...sss......................................psht..HEl.GHs..hGhpH..............................	0	54	83	105
+13425	PF13583	Reprolysin_4		Metallo-peptidase family M12B Reprolysin-like	Coggill P	pcc	Jackhmmer:C2M7W0	Domain	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.65	0.70	-4.80	9	268	2012-10-03 04:41:15	2010-11-29 11:39:56	1	39	198	0	78	3727	359	164.50	15	27.17	CHANGED	sh+shclulssDhoahpha....ushstlpphhhsslsthNclY.s..................pslGhplpLh....sspph.hTss.pss..as........s.s.spps..spthsshsshhGppshDhuhlhp.h....pss.sGLA.aluphs..........p.st.pu.ushuss.............................tp....pa..pl..hAHElGHhhGAsHshs............ussss.osts......-sssGs...oIMu.Y...sssspt..sh...FSssoIphI.th..hp.ushs	..........................................................................................................................................................................h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s....h..h.................................................................................p.....sh......p..s....hs......HElG.....Hs..LGhsH.s..hs.......................su.s.s.s....spsh.....................pps..p...t.h............olMu..Y.........hp..t.s.......................................th.....................................................................................	0	24	45	68
+13426	PF13584	BatD		Oxygen tolerance	Coggill P	pcc	Jackhmmer:C2M5J5	Family	This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	485	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.53	0.70	-5.90	64	896	2010-11-29 12:52:47	2010-11-29 12:52:47	1	20	707	0	273	880	568	397.70	18	74.48	CHANGED	hlh.h..sh..hs.....hAp.....sphpAp.s..s+stlu.sEplplshph.s..p...-s...c..s...........Fps...ssh....ps.Fc.V..hGP..spSp....sp..ph..lNGcso....psh..oaoYhLhsp+pGshoIssApl.hsGpphpopslplpVss.ssppspts..................................tthsspslalpspluKsssYhpEslhlsYKlYhpsslp..hs...hc.PchpsFhsppl...sp..ptphp..ptphsG+sYpslhhcphllaPQpoGcLpIsshshsssl...th..............spt..............p.s.....hF.G.t..p.hp......php+plpusshsIpV+PLPp..h+PpsFsGuVGpFshpssh.....s..p..splcsG-slohplslsGpGNlKhhphP..clp..hP...ssh-hY-schpppsphsssG.hpGshshpasllPpptGpasIPslpFsYFDspsppYcTlsopshplsVtpGs.......ss...sss....ss.......sspppht..spshphlc..p..sshht.h......p.p..phFa..soh.haahlhllshlh.hhl.hh.lhh+c.pttp..ps..clsth..+t+cA..s+lA.p+t...LppApchh..spp.pt	................................................................................hh..........h..ht......ph.sp.h..sp...tl..h...s-.hplph...s....t....ps....p...t............hph...sth.......ts.h....l...hts...p.sp....ph........ph....h..N...G.php..........ph..phthhl.hs...pp.G.htIPshpl.....G..hto.psltlpVht.tttt.........................................................................ttt.h.lps.p...l..s.......p.p.p..h.Y..tpthhhphclhht...........p.........ht.....................t.....................t........hp.sph.....p.s..h..h.hpph............sp...ttphp.................p..h....sG...tpa...pshp...pp..ahlhP..pp.sG...p..hp.....lsshthpstl.......................................................................u......................h..hphps..tshslp.V.p.sh......Pt.....ps..t...a....su....t.ph.p.lst.ph..................s....s....pp...h.psG-sloh..plpl...p...u....p...Gs.ht....h.p.hP....plt......hs......pshp.hY..s.tps..php.....t...s.t...t...t......h.....t..up.hs.phsllPppsGphpl.P.s.l.ph.saasspspphcph..phsshsl...pVtts................t.................................................................................................................................h.h.h.h.hh..h.hh....h..hh.hh.hh...............................................................s........................................................................................................	0	92	174	227
+13427	PF13585	CHU_C		C-terminal domain of CHU protein family	Coggill P	pcc	Jackhmmer:C2M7W3	Domain	The function of this C-terminal domain is not known; there are several conserved tryptophan and asparagine residues.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.25	0.72	-4.10	160	1085	2012-10-03 16:25:20	2010-11-29 13:23:00	1	223	183	3	619	1204	1201	88.80	27	6.67	CHANGED	lhls.N.shoPN.GDGh.NDhaplp.s....l.......ss.splpIaNRaGshVapsp..sYp....ssW.cGp.p.........ptLPsGTYaYllph........sst....ppt..hpGalhl	.......................h..lPs.sFoP.N..GDG..h..N.D.haplp.s..............h..p..ph......ss..hplpIa.....sRaGph.....l.......apss....shs.....................ssW.DGphps..................p.lPsG..sY.aYhlph.......tsst........t.......hpG.h........................	0	364	565	618
+13428	PF13586	DDE_Tnp_1_2		Transposase DDE domain	Coggill P	pcc	Jackhmmer:C2M1K3	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.48	0.72	-3.80	38	2848	2012-10-03 01:22:09	2010-11-29 14:04:42	1	17	787	0	763	3964	388	82.10	27	46.05	CHANGED	lpsD+hYcsccsRphhcc+..GI..+lusssls+ssp............hp.tttstttR.slEtpFuhhK+t.hpLsphhs+Lspottsh..lslshhlhsLc	..........................................................hsD+uY.ps.p.t...R.phhtpp...uh.......phs.lstp..tpptp............................h...s..hph.h.+p....R.p.h.lEphFuplK.p.a....R+..l.......u.....p..Ra.-Khspsahuh..ltlAshhlhh.................................	0	202	519	633
+13429	PF13587	DJ-1_PfpI_N		N-terminal domain of DJ-1_PfpI family	Coggill P	pcc	Jackhmmer:C2M3D1	Domain	This domain is found at the N-terminus of proteins from the DJ-1_PfpI family, Pfam:PF01965. The exact function is not known.	21.50	21.50	21.60	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.60	0.72	-4.42	59	1421	2010-11-29 14:19:25	2010-11-29 14:19:25	1	12	1169	10	438	1155	114	37.70	42	16.10	CHANGED	t+lLhVLTSHDpLGsTGc....pTGFWlEEhAsPYYsFpDAG	....................h+lLhVl..TS..t.s..p...h....s...s...suc....tTGhWLpEhstPYhshpcuG.........	0	117	250	366
+13430	PF13588	HSDR_N_2		Type I restriction enzyme R protein N terminus (HSDR_N)	Coggill P	pcc	Jackhmmer:C2M5G6	Domain	This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA [1]. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.46	0.71	-4.27	81	1412	2012-10-11 20:44:47	2010-11-29 15:02:48	1	34	1136	1	328	1237	289	110.80	21	20.20	CHANGED	PEEhVRQchlp.hLlpchsYPt.shltlEhtlp..h.s....s.pp.....cR...s.....DlVl...aspc..............tp...shlllEsKssplpl..sp..ps..h-QltsY.st.s..h...pupahlloNGhpphhhp..hs..h...ps...p.......p..aphl..scIP	................................................hl...hh.p.p.hs...Y...s........t..........p...l...h.s..Eh....phs...hs................p.pp..................c+.....s.....Dhll.hpps.......................p...PhhlIEs.......K..s..sphpl.......sp..............s...h.pQhhpY.hp.h.......h.....s........spash...loNGptahhhp........t......................................................................	0	106	235	300
+13431	PF13589	HATPase_c_3		Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Coggill P	pcc	Jackhmmer:C2M6V6	Domain	This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.92	0.71	-4.51	55	9547	2012-10-11 19:05:54	2010-11-29 15:33:13	1	80	4481	84	3019	14695	4507	137.90	25	20.93	CHANGED	ho...psAlsELlcNulD.......As....Aps..................lplhls.......pp.........................tsltltDsGtGMshp..-...hh.p...sh.....p.hup...ss.p..p...t.......p.......p.....pps............hGc.hGl.G.KhAuhphupplplho..+...pp...up.ps....s..hp.......l...shphhpppp..s...h.l...ths..pth...............p.hpp..pppGT	..................................................t.hl+E.L.....l....pNu..hD..................As......s.p..h..............................................................................l.cl.p.lc............ps.......................................th....................pp..l..pl.p..DNG..........h.Gh.s....c-........-...........lh.t.....hh..........p...hsp...........o.u....p....p.........p..h..........p.................-.........hpt.....................................................IGp...aG.....h.....G...........h....h....u.....u.....h.....h.....s......s.......s......+.....l.....s...l....p.o..+......ps......sp..pt.......s..ht...............h...........................................................tstttthttttt........................................................................................................................................	0	999	1810	2464
+13432	PF13590	DUF4136		Domain of unknown function (DUF4136)	Coggill P	pcc	Jackhmmer:C2M2E4	Domain	This domain is found in bacterial lipoproteins. The function is not known.	27.00	27.00	27.10	27.20	26.50	26.90	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.91	0.71	-4.15	166	841	2010-11-29 15:34:22	2010-11-29 15:34:22	1	5	488	0	314	779	367	162.60	18	79.98	CHANGED	o..........h......p..lp...sDa....-pss......sF.s.....s...h+Tasahps..........tss....th...s.....sLpp..pRlppulpspLpt+.Gapt......u...p....s.s.Dhhlshthtscp.p........tss............h.s.s.......h............Gh......u...h.........G........au.....s..h..h............G.................s.s...hs..h............spp...h..pp....uo..Lhl-llD........sps..s.........c.........l.lWcGsupstlps...p.s...s....tppt...lsp...hVpplhspaPPp	...............................................ss......phs.th......sa.s.....sh+Tasahps..................st...th...s...sl...pt...p..p.lpsslsppLsp.+.Gap.......s.....sp....su.Dl.....hVphththppp......psh..........................hs.s.....h.............sh.....u...h.........................G................au....s..h..h.................s.................................hs.hsh..............stp....h....pp..ss....Lh..lcl..hD.......sps...s..............p.........h.lWpusupsthss..ps...s.......pppt...htp...hVpphhspaP........................................................................	0	81	179	254
+13433	PF13591	MerR_2		MerR HTH family regulatory protein	Coggill P	pcc	Jackhmmer:C2M362	Domain	\N	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.43	0.72	-4.38	56	920	2012-10-04 14:01:12	2010-11-29 15:57:16	1	2	905	0	189	833	159	83.90	38	81.93	CHANGED	lslsEhCppsslptshlhELl-hGl.lcs.ptt.s...p.....phh.hsspplt.plc+hhRLppDLslshtGlslllcLL-cl-pLppElppL+p	.....................hTlsEaCh+.s.G.loc-pLsElVslGllEP..cp..p....s..........sWh.Fcsc.....sshhVpRAhRL+c-LuLshsGIAlsLsLl--lscL+pEsRhLp.............	0	60	124	167
+13434	PF13592	HTH_33		Winged helix-turn helix	Coggill P	pcc	Jackhmmer:C2M2H6	Domain	This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.39	0.72	-4.43	87	787	2012-10-04 14:01:12	2010-11-29 16:08:47	1	15	372	0	214	1136	242	57.50	29	30.89	CHANGED	ssthWostpltphlpppaslpa.ohsuhs+lL++hGaSap+Pphh.shctDtctpptFtcph	...............................hppchshsY..ohsuhhpLL+.RtGa.p.hpP+sp.PtK..tD..s.pp..t.........................	0	28	108	155
+13435	PF13593	DUF4137		SBF-like CPA transporter family (DUF4137)	Coggill P	pcc	Jackhmmer:C2M6P1	Domain	These family members are membrane transporter proteins of the CPA and AT superfamily.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.84	0.70	-5.33	59	1645	2012-10-02 17:06:44	2010-11-29 16:51:02	1	8	1426	0	476	3347	1338	293.20	43	89.90	CHANGED	chFhlhLlsslhLAthhPs..h........Gpssshhp.t.hssshu.lullFhlpGhpLupptlhsGhtpWRLHlhlhhhoFllhPllsh.ulshhht..s..h...ls................................st.....lhhGhlaLssLPoTVpSuluhTohAtGNlsuAlssAuhSsllGlFlTPlLl.tlh.h...........s.ss...............ssshs.........htpsltplsLplllPhllGQllp...sh..h.s...p.......................aspp..p.cp.h..........lphl....DpssILLlVYsuFSsAhspGla..pplsh..hsllslhslshhLhhlllshs....hhhuRhL.t.............................as+............................pDpIslhFCGS.pKSLA.GlPh..usllFs.sts......tlGhllLPLhlaHthQLhlsuhLApphs+	...................................................................................D.FhlsLlssVll...Aoh.h.Ps...p............G.s.h...s...s.hh...........................h...o...s.hA...I........u..LL.F....F.h...a...G....A......+..L..S......p.....c..tlls..G..h.t.H...W.R.L...H.L..hV..hs.sT.....Fll...FP..ll..G.l.........h.....h.....t.....h.....h.....h.....s.....s..........ls...............................................s.........LYhGhLaLChL..PuT..VQ.SuI.AFTShAtG.N.VA..A..............AlsuASsSsLLGlF.loPLLV....uLlh...............s.sp..........................Gus.s.s..ht.p.....ltp.Ih...lQ.L..........L...lPFl...lGpL......R.....sa......l..u.......s..............................a..l..pR....p....+p.h........lshs.....D.p.....s.....S.....I.....L.....L.V...V.Ys..A.....F.....S...-..u.h.....s.p..G.lW...pp.luh.............ssL.l.h...l.l..ll.....s.h.lL.L.s.l.l.l..s..ls.......hh.hu.+.h..L...G...............................................................F.s..+............sD..c.I.s.I.....lF..CGS..KK.S.L......As....G..lPM..As..l.....LFs..s............slG.h.hV.LPL..MlF.H.QlQ....LhlCuhLApRat...............................................................................................................................................	0	127	265	386
+13436	PF13594	Amidohydro_5		Amidohydrolase	Coggill P	pcc	Jackhmmer:C2M675	Domain	This family of enzymes are a part of a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.77	0.72	-4.15	1248	3712	2012-10-03 00:45:34	2010-11-29 16:53:58	1	83	2104	48	1323	23661	7737	75.40	25	16.55	CHANGED	lhlcss.+I........st..l...................t......tt.....t................l.D.....u.p.G..p.h.lhPGhID..sH.....sHh......................................hhtsh..tphttt......h.....................................sGs...............................T...T..............l	.....................................................lhlpsG..+I....................hs.l......................stt..hsh...............ss.sp.........................ll..D..............s...s..G...p...h..l..hPGhID..hH.............sH.h................................................................h.ts.h..................h.................................................ttGl.....T.o......................................................................................................................................	0	575	1004	1193
+13437	PF13595	DUF4138		Domain of unknown function (DUF4138)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4780	Family	Based on Bacteroides thetaiotaomicron gene BT_4780, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	25.50	25.50	25.60	25.80	23.60	25.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.40	0.70	-5.42	30	514	2010-11-29 22:10:22	2010-11-29 22:10:22	1	2	140	0	63	427	8	231.40	40	82.80	CHANGED	plpVshsKTsHllFPpsI+YVDlGSspIlusKApss-NllRlKA...................sspsF.s-TNhoVITtDGphY..sFslhYsspPsthshph.....................phtssstpshhpphss.sssthpphhhslapps.+cl+plss+paG.....lphhLpuIYspsDhhah+hslcNpSNlsYDIDhlRFKlsDKKhsK+TssQphtlpPlhshNthp..lpsKpshRsVaslsKhTlPD-KlLplElhEKs.GGRphslpIcNsDllcAcsl	.............................................................................s.lpVoasKTsHlIFPus.lRY.V.DlGSs.p.l.lAsKA-ssENllRlKA...................sscsF.sETNhSVI.TpDGsaY..sFNlpYss-PthLsh-h.p......................................................................................sphspsttplY...hp-lss.pS.....shh....h....ph.h..hpsI..a.pps........pRpl++lus+paG.....hphhLculYscsshlYh+hplcNpoNlsa-lDalpa.K.l.sDKKhsK+TAh...QE.hl.Plcs.hs.st..lsu+ps.R.sVasltKFTlP-DKhLhlEl.E+s.GGRp.ohhl-scDllpAc.h..................................	0	18	54	63
+13438	PF13596	PAS_10		PAS domain	Coggill P	pcc	Jackhmmer:C2M6E2 	Domain	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.14	0.72	-3.77	87	1751	2012-10-04 01:10:46	2010-11-30 10:56:59	1	160	1165	5	368	2524	174	107.80	26	18.13	CHANGED	lsslLsohsl.tlsFlDcs.plphass....s...t....p....plhp.hhssslGRslssh....p...sp.....pt..hstl....cp.ll...pplcsspp..s.p.hchhh....s....p..s....s+h.hhh.phhsh+spsuphtGll.shhDlp	..........................hshlLpshPh..-lTa.lDcssphp..a.ass......s.....t....p.....hl..ap...R...s...s.s..p..l..G.+.....s..l.p..p...s........H.........Ps.......tp...hcp...V.........cp..ll.......p.s...l..+.sGpp.......c..h...h..chhh........s.......t.s......Gp..h...h..h..h..p..Y..t...A..h.+..s.p.s...G..p.atGllEhh.Dlp.......................................	0	125	250	306
+13439	PF13597	NRDD		Anaerobic ribonucleoside-triphosphate reductase	Coggill P	pcc	Jackhmmer:C2M7Y9	Family	\N	25.00	25.00	25.80	25.40	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.94	0.70	-6.43	45	3413	2012-10-01 23:28:04	2010-11-30 14:10:29	1	23	2857	5	604	2408	158	537.40	35	83.84	CHANGED	ptchclspsu.Nhs.huht.....tlsp.....hltphahpp...l.s.s.E.hs.cAH.ppG-laIHDL..sh..h...ssYCsuaoLpplLpcGhsslsG.....pS+PP+HhsoAhuphVNFlhshQspaAGAQAhssF-TYhAPFlRtDt.hsYp..............................-lcQtlQchlaNLNhPsR.hGhQoPFTNloh......sp.s.sh.....cs......lhG.sth...........................h.sttht.....s.hp.Ehchlp+Aah-lhhpGDupGpsFTFPIsThslppc...............ppssspt..lachsAKhuh..htsah.............sph.........-Pss......stuMCCRLpl-lp-htp...us..................................uLh...uus.tTGSIuVlTlNhsRLuhpucs.......ccc.t.h.tcL.......pc.h.p.l.s.......t........Rp.hlpchhp.....pGlaP.....a.hcph......Lhs..............L.cspFsTIGlsGhsEss.t.ph..stp..slp.......s.cuc.......phshclLcal+pphpchpccTGhhaNlEtTPAEusuh+hA+tD+c............c..s......lh..........psts...hh....sshats.ssphslshh-chh....hc.pc.lpshhoGGollHlaL.GE.p.h.sscuhtp.Ll+phh.p.hclsYholTssholCsspGalssc.ptpCPpCGpct.............sEhaoRlhGYh+.PVpu.......aNtGK+p.EatcRphap	...........................................................................................................................hh..s.NsNcsu.p.h.h.....sp.tc..........hhus.......hssc.hhhpp.....hLP....pc..ls.pAHpcGDIHhHDL...Da...h....hhsCshlshcshLppGFphGsu........plcsPKSIpoAsu.hspIluplsup.aGGpohsphDphLAPas...ptsh..pchcph.t............................................................................pths.tpsp+-hhpAhQul.Ypl....NThho.usGQTPFsolsa........GlsT.sh..............................................................................+.h.Ip.culLpsp...h...tG...l...u.p...t.+....T.s.lFP.pll..F..slccGh.Nhp..........................s.s.s..NYD...lhpLAhcsusKRhaPsl...................................................-h...........sssh........hs.sMGCRohLts....p.tp.....sp..................................tl..........tpGRs....NLGVlolNLP...R.lA.lcupG................................-ts....t...F.hcl..........-+.h.t.l..s.......p.............................+t.h.h.pc.htc............stshP......h..hh..h......hhphhtt.p...........t.s...hh..+p..u..p..h..o..l..GaIGlhEsh.p...ha..s..sp.....hhp.............st.pu.+.......thslpIlcch+ptsppap.........cc..h..Gh..tFSlhuTPuEuLssRFs+.hDpc......................c..FG.....ll...........slTD+s....YYTNSFHh.s...V.pp.p.sssa-Klc....hE.ts..a..h.ssGGaIpYsEh.sp..p.t..N.cAlcs.lhcauhp..+lsYh.uhNsslDpChp....C....G.........a...........p..........u.........t......c........s..........h........p..........CPp.......CGscc...........ttssVh+RssGYLs....sssp...................astG+pp.ElppRV+H.h.............................................................................................................	0	214	398	520
+13440	PF13598	DUF4139		Domain of unknown function (DUF4139)	Coggill P	pcc	Jackhmmer:C2M2S6	Family	This family is usually found at the C-terminus of proteins.	25.50	25.50	26.10	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.68	0.70	-5.12	85	674	2010-11-30 15:48:01	2010-11-30 15:48:01	1	18	418	0	391	713	87	256.30	16	54.27	CHANGED	lcloYhlss.A...u.WpPhY-l+ls..s.tp....sp.lplshtAtVpQpTG-DWs.sVpLsLSTupPsps.s..ssPpL.ts.Whlph...hpP......s.h......hst...hssh...........s...ttht..t..tt.h...tts.................s.......h..tt.t..h.....tptsht....s.tlppsshu...ssapls..t.holsusupst.......plslsphshsuc.hphhssPph.s.spAaLhAphsss......s.shslL.sGpss.lahDusaVGpsplsh.hss.......Gpchc.lsFGsDctlplcRphh.c.c..p.ss..p.G.hl.......sp.ppp.h.s.hphplpVcNtp....spshp.lplpDplPlSpscclcVph..................p...p....s...s...................ts..............s.hc............spc......GhlpWclsLssGp.spplphsaplcaPc	...................................................................................................................................................lpY.....h..t.s.....W.s.Ychtht......t...t......................t...htl.h.u.l.ptou.sWp.sstl.lsosps............t.t................s.....h.....s....hth.......................................................................................................................................................................................................................................................................................................t..t.t..t.t............htaph..t....hs.l...sstt..............hh.l..p.ph.....s..p..h...h........h.....h..........h.P.th.....p..............t....s.....h...h..s....p..hts...................t..thsl...G..st.lh...........h.....s.....s.....t......a....l....up.s.lt..hss.......spphp..ls..hG.-.tl..p....lp......hp.....p..t......p..tp..........ts.hh...................st...t..p.........hthphtlpNtt.......tpshp.l.l........-th...Ph...s...t....p..ttl.lt.............................................................................................................................................................................................................................................t.....t.h.athtl.stt....t..h.hth.hp.............................................................................................................................................	0	155	261	359
+13441	PF13599	Pentapeptide_4		Pentapeptide repeats (9 copies)	Coggill P	pcc	Jackhmmer:C2M218	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.59	0.72	-4.17	86	6775	2012-10-03 04:02:01	2010-11-30 16:17:53	1	256	2008	57	1619	10345	2693	77.40	16	36.50	CHANGED	sphpsspFpssp.h........pp.ssFpss.....plcsssFsssp.h..........hpss..........Fpssp.....lpsspFpssp.h...pss....pFpssslp.sspF..p..s......p.lpsss.F	...................................................................................................tspF.p.ss.p.h................pt.s.sFp..ss...............plp.s.ssFp.psp.h.......................ppss...................................F.p.s.ss...............Lp.s..ssFp.s..ss...l............pps...................sF.p.s..sslp..ssph.p..t................................................................................	0	562	1041	1333
+13442	PF13600	DUF4140		N-terminal domain of unknown function (DUF4140)	Coggill P	pcc	Jackhmmer:C2M2S6	Family	This family is often found at the N-terminus of its member proteins, with DUF4139, Pfam:PF13598, at the C-terminus.	27.00	27.00	27.00	27.00	26.90	26.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.27	0.72	-3.58	88	387	2010-11-30 16:18:01	2010-11-30 16:18:01	1	13	299	0	212	388	20	104.20	21	17.80	CHANGED	sVTlassu...ApVsRp..us..l.s...l.ts..Gp..p..plhhpsL..Pssl.st..sSl..pl.s...stus.......ssl...tslp....hptp..h....hp.......ttsst.......plpplcpplcplppphstlpschs...sh...ptphphlp	.........tVTla.s.sp...AplsRp.....sp.l.s...L..ts....Gp......s..c.............lhlp.sL..s..ssl..ct..sSl..+V.p...upus........ssl.....hslp.........hptt...h..................ht..........ttt.st............................plpplcpplcplcppht.......tlpsphsshptphthh.t..............................................................................	0	74	133	193
+13443	PF13601	HTH_34		Winged helix DNA-binding domain	Coggill P	pcc	Jackhmmer:C2M278	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.44	0.72	-3.95	35	545	2012-10-04 14:01:12	2010-11-30 16:59:13	1	7	427	1	221	2120	231	79.50	32	70.80	CHANGED	lRLAlhShLhu...V-cA-Fshl+-phpuTsGNLSlplcpLcpAGYIplcKsFpG++PpThh+lTspGRpAFpcYlcuLcphl	..................................RLtlhuhLhs........scp.s.s.F...spL........+.c...hl..s....l.Tc.........GNLop+lptLccsGY.l.p..h...c..K.s....a..t....u.......+....+..............P.p.T.hhplTsp...G...+.......p...A....app....alpsLcph...............................	0	86	153	191
+13444	PF13602	ADH_zinc_N_2		Zinc-binding dehydrogenase	Coggill P	pcc	Jackhmmer:B3CU33	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.83	0.71	-3.24	420	4473	2012-10-10 17:06:42	2010-11-30 17:15:43	1	149	1864	6	1804	17425	4479	130.70	21	25.39	CHANGED	LGA-pll..Dhp.ptth....................h.t..p.hD....lV...........lDs.lG....spsh..pts........h..hh.......s..Gp.h..lth...............................hhthst.t..tthphhhhh.....................t.......ttp.L.....pplspLlcsGp....l+.shls.ps.aP..Lsc..sscAachl.csG+sp.GKlVl	...............................................................................................................................................................hGAptsl.......Dap...ptth............................th.h.pthD.....h.l.....................hDs.hG.....spth....pts.....................h..phl.......tss..Gp..l......lsls.s.................................................t...hth......t..t..t...h..s..h.ph.thhh.............................ht..........................tpp.L...............pp.l.s..p..L.....l....p.p.G..p..............l.....+......s........h..l...s...p.......s...a..........s........l...pp..........st...cA....a.p....hl....c....s......G....+.s...p...G.KlVl...............................................	0	552	1141	1527
+13445	PF13603	tRNA-synt_1_2		Leucyl-tRNA synthetase, Domain 2	Coggill P	pcc	Jackhmmer:B3CR81	Domain	This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.99	115	4853	2012-10-02 18:00:56	2010-12-01 14:32:33	1	35	4641	29	1125	8298	4984	183.30	43	22.35	CHANGED	+NWIG+ScGs-lpFplpst.p...p.......plp.VaTTRPD..TlaGVTalulAPEHPLspcl...scppsplpsFlccs+ppsshEpshtstE..KcGl.hTGhhAlpPls.Gcc......lPlWlANaVL.h-YGT.GAVMuVPAHDQRDa-FAcKYs..LPIp.VIp...sts.tp..p.p........ppAa..s-.cG...hLlNSu....pFsGls.sppAhptIschLc	................................................................................................RNWIG+ScGscls..Fs..l...p....sp....s......p...........................plp..VFTTRPD..TlaGsTah........slA..P..E.........H..s..L..s.p.pl...........................scp...p...s...t........l.......t...s.......a....l......c..c....s.p...p...p.....u.........s.....h.E....c...p......t......s..t..E.........K..p..G...V.....hTG.....h.....a.A....l...p.P....l...s....Gcc.............l.P....lWl.A...s.Y.VL..h..s........Y.GT........GAVMAVPAH.D.pRDa.EFA.p.K....a..s......L..s..I..h....VIp..............sss................h................................tptAa....Tp...cG......h.h..l...N...S....u............h.sGLs...hp..pAhptlhphL............................................................................................................	0	373	737	963
+13446	PF13604	AAA_30		AAA domain	Coggill P	pcc	Jackhmmer:B3CTP0	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.30	0.71	-4.73	84	5200	2012-10-05 12:31:09	2010-12-01 15:00:29	1	89	3798	11	1137	10491	2582	192.00	29	21.89	CHANGED	pLsspQtpAlcplhsssphhsll.GhAGsGKToslpu.sppshcs.............p.G.hpVhGhA.oupAAcs.Lpcs............hG.......lpupTlushltthsp..................................hssps.....llllDEAGMVuocphtcllptspc.sGA.+llLVGDspQLtulpA.GusFctltcphs....sscLsplhRQc......ssht+.pAsptltpGcssp...uLshh.tppGplptsss	..........................................................................................t..t..Q.t....t....A....h...t....t.....s.....l.......t.......p.......p..................l.....h..........ll..oGG.PG..TG...............KT....T....s.......l...p..t.......l.......l..t..h.h..tp.............................................................................p...s...h....p...l...h..L....s.....A......P....T......G....+...A....A.....p....+.....ls...Es....................................................................h..G........................h.p.A...p.....T...l..H.....+....l...L.t....h....p..s.s...s...p..t.........p...............................................................................hh.s.t.s............lll..l...DE.....uS........M...........l..............D...........h..............h.............h.............h............s...........p.............L.........l...........p........s...........l.........s.......s.......................s.........s..........+.........l.lll...GDp.c.....Q.....L......s.......S........V.............t........s.......G..........s..............l.............h...............t...........-..........l...............h..............p..............t............t..............................h.l..p..p..hh.Rpt.....................h......s..h........................................sh..........................................................................................................................................................................	0	339	718	942
+13447	PF13605	DUF4141		Domain of unknown function (DUF4141)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4772	Family	Based on Bacteroides thetaiotaomicron gene BT_4772, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	30.00	30.00	30.20	30.20	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.78	0.72	-4.77	24	314	2010-12-01 19:13:44	2010-12-01 19:13:44	1	1	144	0	39	229	13	53.60	45	25.74	CHANGED	+p+lhhlhhshh.hhsspA+AQWVVTDPuNLAQuIlNos+pIVpTSsTApNslpNF	...........hpplhhlhsssh..lhsspApAQWVVoDPuNLAQuIlNusKpIlpTSpTApNhlpsF..............	0	10	28	35
+13448	PF13606	Ank_3		Ankyrin repeat	Coggill P	pcc	Jackhmmer:B3CUD7	Repeat	Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.	20.00	17.20	20.00	17.20	19.90	17.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.28	0.74	-7.80	0.74	-3.13	248	446	2012-10-02 12:10:21	2010-12-02 11:06:47	1	179	202	0	271	70923	5071	30.10	27	4.47	CHANGED	p..s..p..os....L..p..h.A..st....p...s....p.....h...p.h..l.chLl.p....p....s..s...s...lst	.........................sp.Ts....L...H...h.A.......sp................p.........u.......p................h......-.l....l.chLl.p......p.......s..s....s..................................	0	129	176	221
+13449	PF13607	Succ_CoA_lig		Succinyl-CoA ligase like flavodoxin domain	Bateman A	agb	Jackhmmer:A3JZV1	Domain	This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.21	0.71	-4.57	213	2340	2012-10-02 00:59:22	2010-12-02 13:50:07	1	30	1654	2	873	4427	2578	135.40	36	17.93	CHANGED	sGs.lullSQSGu.luss.lhshutpp..s.lGhSphlShGN.ps.DlshsDhlc.ahsp...Ds.pTcsIhlYlEulpc..u.ccFhpsA+pss..tp.KPllllKuG+.....optGspAA..tSHT.uuluGsstla-Ash+psGllpVcshc-....lh-suph..l	...............GplAhlSQSuAluss..lLc.hApp+......s......l.........G...FShh.lol.Gs..ps..D....l...s..h..s..-..l..L-aL.uc....................Ds..cT..psIlLYlE.....s..l.p.....-.....u...R+....F.h.s...A.A.....R.pA.u....+....s..K...PllllK.uGR...........os.s.u.....t....c....h..s......sHs....u.u..h........A.....G....s....D.....s....s....a....-....A....s..h...p...cuGllRVpshcE....Lhssscsh............................................................................	0	284	570	741
+13450	PF13608	Potyvirid-P3		Protein P3 of Potyviral polyprotein	Coggill P	pcc	Jackhmmer:P04517	Family	This is the P3 protein section of the Potyviridae polyproteins. The function is not known except that the protein is essential to viral survival.	25.00	25.00	25.10	25.10	22.00	24.60	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.53	0.70	-5.36	65	976	2010-12-02 15:02:58	2010-12-02 15:02:58	1	24	129	0	0	1226	0	381.00	35	16.23	CHANGED	shchLIKula+Pchhppllp--PYlllhullSPslLlshassuulEpAhphWlp+cpslutIhshLpsLAcKVShAcsLhpQhplIppsuspLhchlpss.pss.h.u.h....phuhph....Lphh..tpcscssppLhpsGFss.hp.pphhphhEK....pYhptLcppWp-LohhpKhphhhpsp+hptthpptLp.p..sts-hpst.hshSspthhspstpphpsshs.....pshppspphh....psht.pphhshslp.slpthhsDlhphlNlhlllSlLlslhpslpshlppt+ph+tp.ht.thcpccptpplttha.h.a....sphp.p....c.t...ss...ptpFh-a...lc.....phpPcLhphh..p.hh....tp..pp..VpaQu.KsssptpLE+IlAFhuLlhMlFDsERSDsVaKlLsKlKslhuohspc...............Vp..............a.Q.S..LD..-Its.hh--KphTIDF-lsssttss.sssh.-.sTFppWWspQLppNRslPHYRTpG	................h+hLl+ula+P+hhppll.p-PYlllhullSPulLhuhYpssthEhuhphWIpccpslAhlhslLptLAt+VohupsLhtQhplIppsutpLh-hhtss.p..h.u.h.....hu.hp.h....Lphh..hppppssppLhptGass.hp.pphhphhEK.....Yhp.LcptWp-LSahEKhuhhh.t.+hphthpc.lh.p..stsDltuh.hshSspshhtpshppl+sshp.....thtpchpshhpt.phttl.shhlt.ththhhsshhphlshlllhSlLlplsushpshlppp++hKt.htthctccp..tl.hhathh....tpht.s....ptPohpcFhpalp...thsPcLhphh..ps.h.....tp...psVhHQu.K.pssptpLEpllAFhALlhMhFDsERSDsVaKlLNKhKulhuohspp...............Vp...............a.Q.S..LD..-.l.s..h--+phhlDF-Lppst....p.....-..hpFtpWWspQlp.s..slPHYRopG.......	0	0	0	0
+13451	PF13609	Porin_4		Gram-negative porin	Bateman A	agb	Jackhmmer:A3K5H9	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.28	0.70	-4.91	115	4742	2012-10-03 17:14:37	2010-12-02 15:24:35	1	10	840	14	1423	6841	1393	323.20	20	89.64	CHANGED	As.s....sls....u....s....uus.A.tA.ps.....................sVslhGthc..hslt...................hhs.......s.tt....s..............tsts.....t.tssht....ss....s..cl...........shps..........ptphs...sGhs....h..tuth..pL-...................ss....t........s....................................................ss..s......sh..s..............scpu.....hlu..l.su..saGplphGc.......p..ts................sh..pphhs....th....s..h.t....hs.s.hssh....t................h..shs....ss..s.s...........................................................s......................sttsssl.....hhhs..ss......hu..G.h.shussYshsp.ss..ss...................................................st......sphh......slss.s.Y.s...h.u....shssu.su.....as..................psp.sss.......................phhshu.sp..hsh...us.h.............slsus..........as.......phpssssht..s.......................................scts.sht.....luss...a.sh.....s.s..h.s.lsssY........sphc.s..........s....................sssscspthslussYsL..up..pssl..aup..huh..h.csc...s.s	.....................................................................................................................................................................................................................................h..s.shs.....h..h....u..s.s...A...tA..po...................................................oVoLYGhl-..sulp.......................................ah.s................stts......s.................................................psht.......h...t.s.s.sh.......ss..........S.Rh..............Gl+G..........sE-.LG...sG............h..tAhF..pLE.....................ssh............s............................................................ss...s...shh....................sRpA......aVG...Lss..sa...G...p.ls......hGR................p..hs................................hh.....s.hhs......................s...ht......sh..s....hss.h......t..........................h.....h..hs.......ss.............................................................................................................................s.......................phsssl......tah.o....ss.........au.......G..h.phs.ut..Yu.hus.ss..st.....................................................................................................t..tspsa.............uh.uh.s.Ys......hu.......s.hslu...su.............Yt.............................p.pssss.........................................tp.ptht.h...u..us..Ysh...us.h..................pl..su.s....................................Yp...........ps.p.h.p.s.s.hs..s..............................................................................tchs.sht....l..us.p......Y...ph......s.s...h...s..l....t..u..u..Y......thscs...............ts............................................................................ssssp...h....pp.h........s...l..u....ss..Y.t..L..SK....+Tp..l..Yst..hsh...p....s................................................................................................................	0	153	515	976
+13452	PF13610	DDE_Tnp_IS240		DDE domain	Bateman A	agb	Jackhmmer:A3K4H6	Domain	This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.56	0.71	-4.21	25	3068	2012-10-03 01:22:09	2010-12-02 16:00:46	1	16	1006	0	405	6167	734	118.80	40	59.33	CHANGED	upsW+lDETYl+l+GcWpYLYRAVDpcGp.slDahLop+RDttAA+tFh++slcptt...tpPcsllTDphsuYstAlcclt...t..ch.................tplpphpsK.ahNNhlEpcHphlKp+h..pshpGF+ShcsApphluGh-shpslp+sph	..................................h..pW+h.DE.T..Y..l...K..l..p........G.+..W..t..Y..L....Y..R..Al..Ds............c.Gp..Tl.DhhLp.p.p.R.ss.p.u.A.h.tFl.p.+....l....l.pph..........stP..p...h..l.....s..T.....D......p.......u.s..u..h......t...t......A...h..t.p.lh....p...th....h......................................................................t.h..p..Hp....p.....K....Y...hNN...lIE.pDHthlK.t.h..h..........ht.a...p.....S...h..p..o.A....s.h.l.p.G.h.E.s.h.hslh+tp.t.............................................................................................	0	90	222	337
+13453	PF13611	Peptidase_S76		Serine peptidase of plant viral polyprotein, P1	Rawlings N, Coggill P	pcc	Jackhmmer:Q65730	Domain	This family is the P1 protein of the Potyviridae polyproteins that is a serine peptidase at the N-terminus. The catalytic triad in Swiss:Q65730, the ssRNA positive-strand Brome streak mosaic rymovirus, is His-311, Asp-322 and Ser-355.	27.00	27.00	27.00	27.00	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.79	0.71	-4.00	6	57	2012-10-02 13:45:52	2010-12-02 16:11:56	1	12	13	0	0	162	0	123.60	34	5.04	CHANGED	Esll-.clsssccpsIc............Kp..ALhKp+pp.+l..VAN...lsDLsppLopICsEpGIPIl.lDppKR+AI.Ph...........V+L+Hlht.pl...tpDDhat--RhFLEHhst.ppshRssc..+Is.p.VRPGWSGsVI	...........................................lh-.cl.hhc.hch+.....................p..A.h+ch+...p...ppl...lus....lsDLhppls-IChEcshPIphIsssK++.sl..sh...........V+L+Hsht...ch....hs...tpDDMh.s.-RtalpHhsh.ttshp.sc..KIppp.V+PGWSGsll....................	0	0	0	0
+13454	PF13612	DDE_Tnp_1_3		Transposase DDE domain	Coggill P	pcc	Jackhmmer:B3CSW4	Domain	Transposase proteins are necessary for efficient DNA transposition.  This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction [3].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.75	0.71	-4.48	38	1053	2012-10-03 01:22:09	2010-12-02 17:12:34	1	4	328	0	267	2914	378	123.10	32	58.29	CHANGED	hGcsTGIuFIDSTslsVCHNhRI.c.HKVFcGlApRGKoohGWFaGFKLHLllNcpGElluhplTsGNlDDRcPl..ptLscsLhGKLauDKGYISppLhcpLhpp.GlpLlTplR+NMKspL.hshhDKhhLRKRulIETlsDpLKNlsQIEHSRHRSl	.............................................................h.hlDSh.l.l...Cp.hR...t....t.+h.....h...p....s....h.....A.p.h....G..h......s..s..h.....t.......a.......a...a................G...aKlHh..l..h...s..p.p.G...l.h....s...a..h.l........T..u.sscD..hpsh..........h...h...........p.............t.....h............h.............s............h..........l.h........u..D.........cGY...l.u.........p.p...L...h..ppL...h...t........p......u....h............p...l........h........T......................h.......+.........p.........N......M.........c..........t..........t..............h...................p..................c....c.........h....h....h.t.p....Rth...IEoh..s.Lhp.hph.p.hh.........................................................................	0	82	137	182
+13455	PF13613	HTH_Tnp_4	DDE_4_2;	Helix-turn-helix of DDE superfamily endonuclease	Coggill P	pcc	Jackhmmer:B3CR78	Domain	This domain is the probable DNA-binding region of transposase enzymes, necessary for efficient DNA transposition. Most of the members derive from the IS superfamily IS5 and rather fewer from IS4.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.09	0.72	-4.43	117	1593	2012-10-04 14:01:12	2010-12-02 17:48:36	1	20	366	0	326	1064	32	50.00	44	29.09	CHANGED	p+L.shp-plllsLhaLRpshohppLuhtFsl.upoTss+hlpphhshLttphst	.........+L.shED.LhhTLpYlR-Y+TY.cpIAscF.G.I.p....ESslhRtspaVEssLspsu..h..........	0	161	288	317
+13456	PF13614	AAA_31		AAA domain	Bateman A	agb	Jackhmmer:C4FZU1	Domain	This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.60	0.71	-4.29	61	7392	2012-10-05 12:31:09	2010-12-03 11:32:26	1	25	3411	29	2053	16785	5368	138.30	24	29.84	CHANGED	cllulhSshsphGposhAlsluphLuppt.t.........VLhlsh-thsu.tthh.ptttp.................sls-lLhhht....t.....plsshlh..ph....sshshlsshpssp-hptlstpchtpLlpplpp..tY-..hlllDlushhpthhs...lLphscplhlssppsshutpp	.....................................hlhlsSs.p.sG..G.Koo.lusNL.A....hsl...Aptut+.........................Vll..l..D.u..D.....h.....p....p....s......s..h.......s......p.......h....h...s...h.ssp.........................................................Gl..s....p....h.l....ts.t......................................................p..h.p..p.h.h........th.....................sh.h......l......h......s.........s........s......................s.........s.........s......s.........s.........p.............h......l..........t...........s...........p.........p..........h.............t.............p............l.........l......p..........hpp...............pa-............hlllD....s.s.s.........h..h........s.s....s....s.......h....l...h.p.....h...s...ss.h.lhVsp.t......pt..................................................................................................................................................	0	671	1329	1734
+13457	PF13615	Racemase_4		Putative alanine racemase	Coggill P	pcc	PF09739_manual	Domain	This is a family of eukaryotic proteins which are putatively alanine racemase.	22.40	22.40	23.00	25.70	21.80	20.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.26	0.72	-3.77	39	179	2012-10-03 05:58:16	2010-12-03 16:56:07	1	7	148	0	127	188	5	102.40	37	17.07	CHANGED	lsaL.sp.sLt.GDsLAAEalLLaLlSp......VhsR................ss.shs.lGphoLNL...sshstps....................hsppLtphlppllPtsthlslolpsLNs...hphs.P++Dhpss+LhoGlLQLu	.............h.taLop.sLh.GDpLAAEYLlLHLlSp......VasR................p-..shs.lG+hoLNl...oshspss.................................................................sasppLhpllppLlPtohhlshTl-shNp...hphh.P+......KDYpsN+....LhoGlLQLs..........	0	58	76	106
+13458	PF13616	Rotamase_3		PPIC-type PPIASE domain	Coggill P	pcc	Jackhmmer:B3CTU8	Domain	Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.55	0.71	-3.83	68	3691	2012-10-02 13:30:10	2010-12-03 17:11:49	1	35	2370	6	991	7167	3075	115.00	30	30.29	CHANGED	hplhKllsppp...................hsD.SlpspHIhls.................spsttcA.+ppADSIhsslp.sGu.cFssLA+caStD.t..ttpGG......-lsWhs.....tu......phstpFtsslhss.psucl.t.slcoshGhHIlp...Vh-++	......................................................................................................ttt..............................tp..phpspHILlp..s...................................................c......pp....A....cp.l....h....p....c......L..........c....s........G..........s......c.........Fu....pLA+p.h..S..p..D..s...u......s......t..p..p..G...G...................-L.G...a.hs............tu.................phs.s.t.F.c..c.A.shsL....c...............h.....G.....p....l......o....s.......P......V......+.....o....p.....a....G......aH..II+lp-h.......................................	0	308	613	823
+13459	PF13617	Lipoprotein_19		YnbE-like lipoprotein	Bateman A	agb	Jackhmmer:B8H670	Family	This family includes lipoproteins similar to E. coli YnbE Swiss:P64448. Protein in this family are typically 60 amino acids in length and contain an N-terminal lipid attachment site, which has been included in the alignment to increase sensitivity. The specific function of these proteins is unknown.	22.60	22.60	25.70	25.10	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.87	0.72	-4.34	77	733	2010-12-04 11:44:36	2010-12-04 11:44:36	1	2	727	0	121	293	18	58.00	58	90.54	CHANGED	hhhhhshhsshhlu.uCo.......Pplclp.sPc..cPIsINhNVKI-HEIclKVD+-l-sLlpspssL	..........hhlsuhhuohhLs..GCT.......PRIEVA.APc..EPITINMNVKIEHEIhIKsDKDVE-LLcoRSDL..............	0	26	57	89
+13460	PF13618	Gluconate_2-dh3		Gluconate 2-dehydrogenase subunit 3	Bateman A	agb	Jackhmmer:B8GVK2	Family	This family corresponds to subunit 3 of the Gluconate 2-dehydrogenase enzyme that catalyses the conversion of gluconate to 2-dehydro-D-gluconate [1] EC:1.1.99.3.	23.40	23.40	23.40	23.40	22.60	23.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.74	0.71	-4.00	170	695	2010-12-04 12:21:38	2010-12-04 12:21:38	1	6	483	0	300	712	280	143.80	22	62.23	CHANGED	sspch.phlssls-tll.....Pps.ch...PuAt.....t......................................ssls.tFl-phlss............................spp......................................p..phhptGlst....l-phspppa..sps.FssLssppp.stlLpthptsph.........................................t..........stF....F.phlpshslpGaas.s.h......atGsps.hht.a................hPG	................................................................tpchshlpuhscpll.....Pp-..c......sGAh.....p....................................ssVs..tFIDpplss..........................s....t................................p.phaptGlss....l-phupppa.....scs.FspLs.s.t.pp.-plLpshppsph.................................................t.th..sphFF.shlhp.shpGaas..sPh..............asGsps.hhu.a........hP.........................................................	0	78	182	257
+13461	PF13619	KTSC		KTSC domain	Bateman A	agb	Jackhmmer:B8GXL8	Domain	This short domain is named after Lysine tRNA synthetase C-terminal domain. It is found at the C-terminus of some Lysyl tRNA synthetases as well as a single domain in bacterial proteins. The domain is about 60 amino acids in length and contains a reasonably conserved YXY motif in the centre of the sequence. The function of this domain is unknown but it could be an RNA binding domain.	21.40	21.40	21.40	21.50	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.82	0.72	-4.33	89	426	2010-12-04 12:39:23	2010-12-04 12:39:23	1	7	377	\N	139	373	132	59.70	28	54.38	CHANGED	lsS..SslpuluY....DspsptLplpF.....psGs....h.YpYhsVPtplapshhs..As.......ShGpaasppI.+....sp.Ys	............S.otltulsY....DspsphLclpF.....psGs......h.YpYhsVPtplapshhp....us.......StGpaapphI+.....sp.a....................	0	31	81	109
+13462	PF13620	CarboxypepD_reg		Carboxypeptidase regulatory-like domain	Bateman A	agb	Jackhmmer:B8H1B8	Domain	\N	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.92	0.72	-3.92	622	6052	2012-10-02 19:08:27	2010-12-04 12:41:19	1	501	1121	14	3219	18992	4276	80.30	21	11.43	CHANGED	s..lpGpV...p.D.s...s.G..t...sl......ssAsVp...l...pt............t.....s...........t......s...ts......s...h.T..s.ss.Gpapls..tl...s.s.....G..s..Y..p..lps.....st.G..ap..stp.h.............p..ltl.p.s...s..p.....s..t.s...l...s...l...s......L...p	...............................................lpGpV.........h..-.s.....s..G.....p..........s.l.........s.sAs..Vp.........l......t....................t.......s......................................h.......s.....ts................s....tT......s.....s.s..Gpa..p...ht......t..l..........ss.......G.....s....Y...p..l.p.s...........s.t...s...G......at....stp.h...................................ltlt......s..t...............h..t.h.............................................................	0	1542	2401	2868
+13463	PF13621	Cupin_8		Cupin-like domain	Bateman A	agb	Jackhmmer:B8H2W4	Domain	This cupin like domain shares similarity to the JmjC domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.79	0.70	-4.88	90	2241	2012-10-10 13:59:34	2010-12-04 13:30:07	1	98	579	36	1539	2844	306	243.80	17	46.84	CHANGED	spph...pchlspspPlll+u..hs..p..c..WP...shpt..Wpp............hcYLtpt.hss.htVp.....................sthts.t.t.sth......................................................................h.tt....s..hp.hhs..h.p........ttphshpch..................................lsp.lpptt..........t...................................sh.Yl.................t.....sss...l..sp.ph.st..l.t.......................p.....c...........psls...h.hs...thh......s..t.............................tss.........................................................lWlG..................................stp..s...p...oshHaDh......h-....................NlhshlpGcKcFhLhPPpphs............pL........................Yh.s............................shp......................ts...s..........................................................................................................................................h.....Sh...............lD.h.p................................................psDh..p.........caP..phpps.........ps.hhspLpsGD............sLalPuhWaHcV.............................cu.......h...............ss....hslulNa.Waptt..st	.................................................................................................................................................................................................................................................................................................................................................................h.........h....tpPhll.ps..h.h....t.....t......hs.........s.hp.t..Wp.............................phh.ph...h.s.p.h...l..........................................................h.t...t.....................................................................................................................................................................t...t..................thph.sh....ppa.....................................................................................................................lph....h....pp....tt.....................t.............................................................hhhh.....................t......ppth........p...th.......s.t.l.h...................................................................................................t..c...............ths..........h..t....th.h.........s...pt......t..................................................................ths.................................................................................................................................................................................................ha.h..G.....................................................sts.....s...h...osh..Hh..D............h.p...............................s..h..h........s....l......p.........Gp..K...phhLa.s.P...p.p....t...t.....t.l.........................................a.t.........................................................s................................................................................................................................................................................................................................................................................................................................................................................................................h.s.......l.s..h.t..................................................p.sh....p.........pa.P.....th.tps.............ps..h.cs...hl..p.sG..-..................................hLal.....P..stW.aHt.V...........................................................................................................................psh..........................t......slulsh..a......h......................................................................................................................................................................................................................	0	639	928	1286
+13464	PF13622	4HBT_3		Thioesterase-like superfamily	Bateman A	agb	Jackhmmer:B8GZN3	Domain	This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.85	0.70	-4.64	200	2392	2012-10-02 20:54:35	2010-12-04 15:19:22	1	22	1107	8	1028	4235	1639	249.30	20	84.50	CHANGED	hsssWt............................sthsaGG.hss...ullhpAhppt...............tss.....................hthhplsssalt.ssssu.shpl.....pscslR.........sGRshshlpspl..hp.......sut.....................s..sspupsshhpsp.t..............................................sshP.sP........spp........h......................................h-h+hh......................................hsssss..hphWhRhp.ssh...........................................t.........lhhlsDsh..sshshthhs.........................................hss.slsh.....olp...............h.......................t....phP.t..sp...........Wlhhcs.....psphsssGh..uttpsplaD.................pp.G..hlupupQsshl	..............................................................................................................h..............................ttsaG..G..lhu............p.s....l....hs.Atcss..........................stt...........h.spSl.p.s.hF..lt..su..s.....s..s..P..l.hh.........pVcpl.R..............cG.+o..hsstp...Vps...h.Q.............pGc..........................................s..lhpspso.Ftt...tc.ps.................................................................t...sshP.................s.P-p....h...s..tt.....h.............h................................................................h-hR.hst...............................................sststts...h...thWhRsp..ssh.ss.........t.................................ph......t...........LshhuDhh.........sssh.h.hhtth........................................................................hhhs.....ol-h.....sha................................................h.ctP..hph..sc.........Wlhhpt.............pos.u.s.su..h..uhspuplas............................ps.G.pLlAsstQpuh................................................................................................................	0	253	600	877
+13465	PF13623	SurA_N_2		SurA N-terminal domain	Coggill P	pcc	Jackhmmer:B3CTU8	Domain	This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.84	0.71	-4.21	6	236	2012-10-02 13:36:56	2010-12-06 09:20:05	1	9	235	0	66	1450	838	139.80	32	20.93	CHANGED	LGKIRS..KGslLlhlIGLuLFAFlA.psh.RSCpus+sppRpQVGEVhGEKISlQDFQKhl-EYppsIK.hp.tp.s.....ppE..pQVKDtVWpphVsN+LlEt-AK+lGLTVT-pElQsVLptGsNPhLhQT........PFV.pQ..TGRFDssuLKpFl	......................................................................................LppIRs..K.us..l..L..l.l..l.I..G...lA..LF..AFlh....u.sh....hp.s.....t...s.........t....t...ps..p.p.....V.G.c.Vs..G-.p.Io....h....p-....a....p...p....h....V....-..p........h...s..t..h......+....hp..t.Gt.....ss......................hsp..p............s.......Q..l..+..cpV....WpphVpptll.pp-sc+LGlsV..octE.l.p.s.ll.....t........s..s.s..P...hl.hps..........Phh...ss.psGtFDtstLppal................................................	0	27	54	61
+13466	PF13624	SurA_N_3		SurA N-terminal domain	Coggill P	pcc	Jackhmmer:O66854	Domain	This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.88	0.71	-4.24	9	2783	2012-10-02 13:36:56	2010-12-06 10:42:40	1	22	2338	1	800	3368	1934	155.70	23	29.90	CHANGED	MhchIR+..p..s....c..hhtslhsllshhFhLh..uhtuh.pp.h.upp.ssVApVsGpsIphp-ap+.....chc....h......hpp.hp......sp..........tpch.....lppt.....lLcshIs+cLLhppAp+hsltVoDppVsctIpp.PtFQ..s.GhFstphYpphLtpsshostpaEp.l+cplhlp+ht	...............................................hpt........t...................hh.h..h..h...h.h..l..l.h.l.s.F..h...h.s............G...l..s.....uh.......h........h..............t.....s.......ss....s.......h....s...A....p....V.s...s...pc...I.op..s...c...acp......................t.hp............p......................p.p.p.hp.................p.p.h...........................t.t.pt....................l.+pp..................l.LspLIs.ct....L.L....t.p...h......A.........cc..h...s.l..s...l....S...........-......p....p...l......c.........p........t.........l.........h........p........h.........s........t.......F.......p......s.....s.......G.........p.F..s..p...p..p..a....p.t...h....L....p...p..................u..h..o.....s.....c......p.at......ptl....+pplhhpp..h..................................................................	0	290	539	681
+13467	PF13625	Helicase_C_3		Helicase conserved C-terminal domain	Coggill P	pcc	Jackhmmer:B0SDT2	Domain	This domain family is found in a wide variety of helicases and helicase-related proteins.	32.50	32.50	32.50	32.50	32.40	32.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.37	0.71	-4.38	93	1240	2010-12-06 10:42:54	2010-12-06 10:42:54	1	14	735	0	510	1049	240	129.40	30	19.02	CHANGED	sllVQuDhTlll.s.ups.s.sp.hs.c.tlushA-l.E.Ss.ttspsYRlTshSlhpAhsAGhsA-pllshLppaS...+hsVPQsLhhhlsDsspRaGpL+l.....tt.....s..u...hhlcssD.slLs.clhtstph.pslhhcc.l..uPssl	...........................lllQu.D.t.T.l.lL-s.s.p..t.sc.tA.c.tLsshAEh.c..ps..pplHsYRlTshSLasAhusGhss-pllshLtca...S.......+h.s.V.Pp..u......Lh.h.......hIs-..ssp.caG+l+l.....tp..................sthhlcssD.slLppl......Lpsptltshhht.p.ls.t.................................	0	192	352	454
+13469	PF13627	LPAM_2		Prokaryotic lipoprotein-attachment site	Coggill P	pcc	Jackhmmer:C6QHI9	Motif	In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached [1].	27.00	27.00	27.00	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.18	0.72	-4.14	142	1185	2010-12-06 13:22:07	2010-12-06 13:22:07	1	2	1178	0	174	520	13	24.30	50	36.96	CHANGED	hhlhhhhs..shsL.uGCGpKGsL.....Yh...P	........hlhllls....hhuL.oGCGhKGPLYhP..............	0	30	73	125
+13470	PF13628	DUF4142		Domain of unknown function (DUF4142)	Coggill P	pcc	Jackhmmer:C6QAI3	Domain	This is a bacterial family of unknown function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.45	0.71	-4.15	144	804	2012-10-01 21:25:29	2010-12-06 14:02:49	1	5	412	0	357	1141	171	133.60	25	68.88	CHANGED	ss.Dpp.FlppAutushhElpuu+LAh.p+u.psspVKsFAppMlpDHspsspcLpplAp.....ptslsls......ttlstpppttl....spLpsh....sG.tsFDcs.Yhspt.lssHccsl...slhcp.h..sss......upsscLKsaApp.sL..PslppHLptAcpL	.....................................................t.t-tpFlppsstushhEl.puuclAh.p+.u.pss.p...........V+sFAppMlpDH....sp....ssppl.t.p.l..Ap........................p.t..slp.ls.......................tths.sp...tpshl....................spL..p.sh........pG.tsFDps.Ylptt.lssHpcsl...shhpp..h..tts......ucsspL+shApp.sl..PslppHlptActl................................	0	95	200	267
+13471	PF13629	T2SS-T3SS_pil_N		Pilus formation protein N terminal region	Coggill P	pcc	Jackhmmer:C6QEC4	Domain	\N	21.50	21.50	21.50	21.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.18	0.72	-4.45	188	1023	2012-10-03 16:25:20	2010-12-06 15:01:29	1	19	613	0	374	1013	88	71.40	24	16.39	CHANGED	sspslplshupupllph.spshpp..VhVusPplADspl.h.......ssp.....plhlhGKpsGsTslhla..spsup...lhshpltVs	.......................s..ttlplshupup..hlpl..s.p...s..hpp.......lhlu..sPplA.Ds.pl.h................ssp......pl.hlhG+.phGsTslhlh.....spsup..htshsltV........................	0	99	193	279
+13472	PF13630	SdpI		SdpI/YhfL protein family	Bateman A	agb	Jackhmmer:C7PMJ0	Family	This family of proteins includes the SdpI and YhfL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.65	0.72	-4.27	205	1094	2010-12-06 15:14:03	2010-12-06 15:14:03	1	8	814	0	214	904	57	75.20	21	46.31	CHANGED	sphc.Nh.hhGlRTsho..........hps-csWcpsp+.......huG..hlhh....hsGll..hllhuhh................thhhhlhhhhhllshlls..hhhuh	...........................hc.Nh.hhGhR.osho..........hpsccsWctsp+..............huu....hlhh.......hsGll...hllhuhh...hh...............shhhhhhhhhhllh.hlhshh..............................................	0	82	154	180
+13473	PF13631	Cytochrom_B_N_2		Cytochrome b(N-terminal)/b6/petB	Coggill P	pcc	Jackhmmer:C1Z9G2	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.20	0.71	-4.46	68	102102	2012-10-03 10:28:09	2010-12-06 16:15:23	1	28	38793	95	787	97053	2443	142.10	66	51.21	CHANGED	.hhhlshhlHhhRshahGua+.ts+.phsWhlGlhLLlLshhpuFhGYsLPhs.hShhuhpl.hs.slhpu......lPhlG...shlh.hlaG.........G.hssss...hlsR.hash.Hl.llPhlllulhhhHlhl..l..pppspts............s..h...tp...ps.......sh..........st............hsaaPhashKs..h...hhhh.h...h...lhllh..........sls...........hlsP.....hh.hhsP	.......................................................ShFFIClYlHIG.R..GlY.YGSYh.a......pE.T..WNlGllLLh..hl..MuTAFhGYVLP.W.GQM.S.FWG.A..TV.IT.NLLSA....................lP..Y.lG..............ssL.Vp.WlWG....................G.F.S..V.D..s.A..........TLTR..FF.u..h.HF.lL..P..Fl.........IsuhshlHLlF..L...H.E.T.GSNN.....................................Ph......Gl...sS................ss...............DK...........................................IPFH....PYa.oh.KDl.....LGhh..l.h.....lhhLh...................Ls...........LFsPslLGDP......................................................................................................	0	232	504	660
+13474	PF13632	Glyco_trans_2_3		Glycosyl transferase family group 2	Coggill P	pcc	Jackhmmer:C6QI89	Domain	Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis [1][2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.46	0.71	-4.59	101	2553	2012-10-03 05:28:31	2010-12-06 16:25:28	1	20	1785	0	422	13191	1466	214.50	30	54.65	CHANGED	hllllDuDsh.l....sssplphh....st.h.ht..p..s......c.hs...hlQ...t...hh..s....h......s.h..p..sh..h.pphhshh.......h....sp.thhpthhhtt.shst.sss.......hs..Gssshh.chpu..l.p................cls..............has...st........slu.EDhchuh+L..h.ttG.....hph....has...............................st.s.......th.pct...ss..o.......................hts.hhp..........Q.ptR..WhhG......................................hh.........................................hh....h..........t.h.h.....tph..h...h...th...h.h................hth...h........hh.....hl.t......s..h...h.h......................hhhhh.....hh.h............h.....lhhhh..hh	...........................................................................................................................................................................................h....hDt.-sh.l......s.........l..h......................h....ht...p.....................................hs...........hh...............h........hh.......s.......................p.......p.......ph.........h....s..h...h....h......t..........................h..............h.....h..s....p...t....h....s.......s.....p..s......p..h...G.u....V..h.s............................s.s....G...s......s.A...h.Y..RR.SA...l.h.........................................................................................pst...............................................ha+..GcsS.............c.a..G...E..D...+...H.LTI.LM......L..cA..G...........aRT...........-YV...................................................................Ps.A.........ls..uTl.....VPc...o.........................................................lts...aLR............................Q...p..L...R....W..ARoo...............................hhp....................................................................................................hh......hh...................h.h...h.........hs..l....h.....t.........sh........s.s......................................lhl.......s............lu......sl..u......u..l..s.p.....................................................hhhsh......hh...................hhshhhhhhhh......................................................................................................................................................................................	0	153	264	364
+13475	PF13633	N_methyl_3		Prokaryotic N-terminal methylation site	Coggill P	pcc	Jackhmmer:C6Q9T5	Motif	This short motif directs methylation of the conserved phenylalanine residue.  It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596. It is often described as TypeIV_pilin_GFxxxE.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.19	0.74	-7.04	0.74	-3.62	363	98	2012-10-03 10:38:27	2010-12-06 17:09:35	1	5	70	0	17	1401	206	22.00	46	13.90	CHANGED	aoLlElllulsllu.lshsshhs	.FoLIElhIuhsIlulhAhshh.....	0	3	7	14
+13476	PF13634	Nucleoporin_FG		Nucleoporin FG repeat region	Bateman A	agb	Jackhmmer:Q5A223	Family	This family includes a number of FG repeats that are found in nucleoporin proteins. This family includes the yeast nucleoporins Nup116, Nup100, Nup49, Nup57 and Nup 145.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.48	0.71	-12.53	0.71	-3.85	444	1433	2010-12-07 09:26:20	2010-12-07 09:26:20	1	64	197	0	1107	1448	4	103.60	29	24.15	CHANGED	s......sss..........s.........................sss....s.........u.....uhFG........s........ss.........s.........s...........s..................s.uh...F..Gs.........s..s..........................s.s...s.......ss........uulFG.......s.........s...s......t......................s..................ss.u........u..uLFGs......ss...........t...............t..s..s..............s..s........u..uL.....FG.....................s....s..s...t.................t..s......s.....s...s.uul..FGs....s.s....ss.......................................................................s.......sssuulFG	...................................................s............tssulFG...............s........pss..............s....s...........................uuLFGs.........s.ss..............t.....ss.s........su.........GGLFG...s......s..s...s.......................ts.............ssu......G..GLF.Gs....ss........s.................t..s...s........s.u........G.GL...FG.........................s...s.s.........t........p.s........ss......uuGL...FGs....s..s...ssp................................................................s.................................................................................................................................................	0	342	639	994
+13477	PF13635	DUF4143		Domain of unknown function (DUF4143)	Coggill P	pcc	Jackhmmer:B1L4V1	Domain	This domain is almost always found C-terminal to an ATPase core family.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null --hand HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.61	0.72	-3.81	579	2818	2012-10-11 20:44:47	2010-12-07 09:58:11	1	13	1059	0	687	2443	408	200.50	18	50.27	CHANGED	lpcD..lhp....h...ht...........hpsht..thpplhphlstphup.hshpplupthpssptsstp...............hhphhhthhhhhhh.shtspttpphtps.KlYhhDsGLhss.hhsh.........hh...............s..hGtlhEshVhpcLh...........pp.............t.laa....ac..................sp..st.....t..ElDh....ll.p.........ts.....ph......hslEVKtu	....................................................................................................................................................................................................................................................................h...Dh.t...t.......thtphhphhhsphsp.hshpphsphht.tttph.t..........................................................................hhphh.tshlhhhh..hphptppthtpt.KhYhhDsGLhss.hhshp.................................s..hGtlhEshVhp-Lh.....pp.....................thp..laa..a+..............................sp.....ss..........t...ElDall..p..p.......ss.....phhslEVK...........................	0	283	483	591
+13478	PF13636	Nol1_Nop2_Fmu_2		pre-rRNA processing and ribosome biogenesis	Coggill P	pcc	Jackhmmer:B1L5U4	Family	This family represents an evolutionarily conserved sequence motif of a set of proteins that are involved in pre-rRNA processing and ribosome biogenesis in S. cerevisiae.	23.90	23.90	24.10	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.25	0.72	-3.94	150	1049	2012-10-10 17:06:42	2010-12-07 11:38:25	1	3	1010	7	195	1177	35	103.90	35	24.07	CHANGED	lah.h.....th.t.s...h.pth.......+lhR.GlplGc..h....+Kp+acPoaslAh..s..............ltppph.pp..s...l-..L....sp..-....pht..pYlpG-sl......................pl...s..p............p...t.p..G.alllshcuh....slGaGKh..sss.plKNhaPKGL	...................h..hh...t.h.ss..l..spL....+lhRsGLcLGph......KK...pR...FEPSaALuh..u..........................Lp.s.s....p...s..pp..s...l-.l........sp..-......phhcYlpGEsl........................................pls.p............s..s.pG...ahl.lsh.c....Gh....................sLGFuKh....sG.s..hlKNhaPKGL..................	0	71	130	162
+13479	PF13637	Ank_4		Ankyrin repeats (many copies)	Coggill P	pcc	Jackhmmer:C6QI42	Domain	\N	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.74	0.72	-3.35	86	7425	2012-10-02 12:10:21	2010-12-07 11:59:11	1	2308	729	31	4885	95319	6198	53.50	28	8.01	CHANGED	thss..lphAsh.......psp..hph...lc.hll.....p..p..s..hs........hsth.....s..tt....st..s...slph.As...tts.....p....h.phlphL.l	..........................................................................................os.LahAut.................pGp.......hc.l........lc...hLl..................p....p....G......us.........................................lstp.........s.......pp........................Gt........T............sLah..As..........tpG.............p...........h.phlphLl................................................	0	2429	3032	3970
+13480	PF13638	PIN_4		PIN domain	Bateman A	agb	Jackhmmer:Q5AFK9	Domain	Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.84	0.71	-4.05	147	2263	2012-10-03 20:43:45	2010-12-07 14:09:18	1	39	1676	9	998	2073	447	140.90	26	23.81	CHANGED	aVLDTNVLl..cc.pslhp..h.............................pcpp..llIPhsVl-ELDphKpppp.......................plsphs..c...............ps.h....p...hlppt........hptt..........................t..sp.l........ts.....pph.......................pp.pl.....t...........................p............p..sDsp..ILssshthppph..........................tppl..lLlocDhNLRlKAps.hGltup........s.ap	.................................................................hVLDTNVLL.....p.c.....s..p..s..l.h.p.h...............................................................pcpc...V.llPhsVlcE....LDthK+ttp........................................................clupp.A.R...............p.s.h..+...hl-ph.....htpt.......................................s.tph..........hh.ppt.......................ptph....p............................................p.......tpsDs....p......ILsssht..lppch...................................................................................tppV..lLVoc.DhshRlKApu.hGl...spph...........................................................................................................................................	0	359	614	836
+13481	PF13639	zf-RING_2		Ring finger domain	Bateman A	agb	Jackhmmer:Q5A9Y7	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.26	0.72	-4.13	329	15070	2012-10-03 15:03:13	2010-12-07 14:28:22	1	495	529	19	10132	21355	1292	45.90	34	10.07	CHANGED	tpCsIChpph..................t.ppsh.....tl......s..C.........s....H.h.FH....tp....C...lpp....a...........h..............p...p......p.......t.....................pC..Ph.CR	....................................pCsIChpph..........t........................tcpht..........hL...................s...C.......................s...H....h...FH....tp........C....lpp......W............................l............................p..p.......p.......p.....................................................sC..Pl.CR................................................	0	3177	5561	7989
+13482	PF13640	2OG-FeII_Oxy_3		2OG-Fe(II) oxygenase superfamily	Bateman A	agb	Jackhmmer:B8H030	Domain	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.84	0.72	-3.49	172	3739	2012-10-10 13:59:34	2010-12-07 14:54:39	1	75	1689	20	1686	4120	5084	99.90	24	31.62	CHANGED	htlphh.psGshhs................hHhDs............................sp+tloh...lha.Ls.sp..................pGGplphhst.........................hssh.ttlt...............PphG.plllFpu..........ppshHtVtss........tst..pRhslssaht	.............................................h..h.pY..tsG.p..tat.................................hHh.Dsh.....................................hsp+pl.oh...llY..Lstsp....................................cGGchhhhs..............................................................................tt...tplp.........................PttG..pl..llF.u................psh.HpVpsV..............tpupRhuhshWh.....................................................	0	587	994	1366
+13483	PF13641	Glyco_tranf_2_3		Glycosyltransferase like family 2	Coggill P	pcc	Jackhmmer:C6QF57	Domain	Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis [1][2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.59	0.70	-4.56	37	8712	2012-10-03 05:28:31	2010-12-07 15:09:08	1	130	3503	4	2974	39049	8776	233.50	18	43.38	CHANGED	Pp..lsllls.shppss.....hltc...slp..shl..s....t..a....sp..hclhlhs..ps......ss....pts.h....p...h.hp....thttths..sht..hp.hl.t...s...p....G.tsKstsl.tpshp..t...........h..p.........sc......hlslhDuDshl.ssss.ltthhshh.........tp.......phshlp.s.h..hs...p..s...tp......sh.......................hs.h.....s.......h.chstpph..thhhhp.....pt.....h..s..h.s.s.h..s....G.ss.hhhcpssl..pcht.............t......hs.............hhhs..-Dh..thshpltp...tGhpst..h..h.....s.tsh...............shph......ts......ps....hts.hh+pptRWhhu	....................................................................................................................................................................................lslhl.s..sa..s..Et...............sl.tp........slp.......ul..h......t.........s...a..............sp........hclh.l.l.s.....Ds............................s.s.............-..p..s..h.........................p..........h...h....p............................t...h..........t....t.......h.s......t.h....................h.p....h....l.t.t..........................s.............p........s.................s..K......u.....t..s...l....st..u.h.p.....t..........................................................................s..p................................s-............hl..h.lh..........D.u..D....sh....h...s.....s....s...h...l.t.p..h.l..s.hh.............tss............................pl..u.....h.....Vp...s....h.......th.............t.....s.......ts................sh.....................................................................h.s.p.h.........tp...............h...p...h.....t.....h....h...h..t........h..h...t....t...s.p........................p.t.........................h......s......s.....s....h....h........s.............G...s..........s....h.......h...h....R..+.....s..s..l.......c.p..l.G.................................................................................u......ass.............ts.hs...ED.h......clu..h.+..l...tp........t......G..a......p.....hh......a.......h...........s...ps.h.........................................s.h.t................hs..............ts..........htt...hhtpp.RW............................................................................................................................................................................................................................	0	902	1889	2484
+13484	PF13642	DUF4144		protein structure with unknown function	Serrano P, Geralt M, Mohanty B, Horst R, Wuthrich K	kellrott	Shewanella amazonensis SB2B PDB:2L6O	Family	A family based on the three-dimensional structure of YP_926445.1 (PDB:2L6O)	27.00	27.00	28.80	28.40	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.43	0.72	-3.68	25	104	2010-12-07 17:52:53	2010-12-07 17:52:53	1	2	92	1	28	77	3	100.70	41	86.07	CHANGED	WPulLKhsGcDELlYLsSpp-a.pEs..pphhhsssDhLIDSpGpsYtlpp................ssptssLhhpsphlslpclhpLlpsHshtpupsCssKltFsolpQul-hls	................................................WPslLKL-GDDELlYLsScsDhpsEs...shIhsssDplI..DSpG.sYsl.s................ssstssLhtpspplSl-EsocLIQpHEFsLApsClsKIpFpTlspAhpsL...	0	6	10	19
+13485	PF13643	DUF4145		Domain of unknown function (DUF4145)	Bateman A	agb	Jackhmmer:C7Q403	Domain	This domain is found in a variety of restriction endonuclease enzymes. The exact function of this domain is uncertain.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.09	0.72	-4.13	91	970	2012-10-01 22:14:54	2010-12-08 10:52:41	1	24	854	0	191	795	46	92.90	23	13.40	CHANGED	pcAt.phh.t.s.s.....p.uuu.....shhRpsLEtlhcchs........t.....psp.....................s..........L.........tpcIsplhpps......stpl..tchh.....................cs...lRhlGNpusH...s.....p.........p.lsp.........p.D....stphhc.hlc	.............................h..Acphht.s.s.s.p.sss..hhhRpslEthl+hlh.........p.....psp.....................s..........L....pshlpp...hshpsh.....lsspltp.th.....................chl+phGNpAsH....s.....t............chst.........c-....u.hhhp...h.............................	0	57	112	150
+13486	PF13644	DKNYY		DKNYY family	Bateman A	agb	Jackhmmer:C2M6R1	Family	This family represents a group of proteins found enriched in fusobacteria. These proteins contain many repeats of a DKNXXYY motif. The repeats are spaced at about 35 amino acid residues intervals. These proteins are likely to be associated with the membrane. The specific function of these proteins is unknown.	22.50	22.50	22.50	22.60	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-12.04	0.71	-3.98	31	664	2010-12-08 11:29:52	2010-12-08 11:29:52	1	11	134	0	233	689	10	122.90	17	66.51	CHANGED	asKD+splYYhs.......c.....clcs......sDs........poFch.......ls.......c......p..a....spDKsslYh....tspp..l.........shs..spsh...chl..............spp.....hhtp...stsphh..............hhp..hpp.............t..p...............hpsls.tYht.DKpplYa........t....t..phchlc.......shDhp.........ohc.ls...sh................aspDcsslYa....ts...........p.............plpssDs..soFchl...............s.t..hah+DKsp.lYh..t.s	.......................................................................................................................l.t..s..........oh............ht....................h...........hDp.thYh.....t....h............................................................................................................................................................................................................t......a..........................................p............th..t.t......sh...p.h.................................................hhpDtpplYa.....t..................................p...................................l..ths...tsht.l..................t......h....hDt........t..................................................................................................	0	78	218	226
+13487	PF13645	YkuD_2		L,D-transpeptidase catalytic domain	Bateman A	agb	Jackhmmer:C2M5S1	Domain	This family is related to Pfam:PF03734.	27.00	27.00	27.00	32.50	26.40	24.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.99	0.71	-5.04	56	379	2012-10-02 23:30:06	2010-12-08 12:37:36	1	3	278	0	115	362	40	172.30	39	70.48	CHANGED	applph..p.spl.shpshppAlpuapplppp..h...ppslLTlIDaopPSsp+RhaVlDlppp+lLapohVuHG+NSG......p.ph...A......spFSNpssShpSSLGaYhTspTYpG+pGaSL+..LpGLEcGhNDNAppRuIVlHGAsYsspsaI+ppGRLGRShGCPAlP.plscplIcsI...KsGoslFlY	............................h.......tstl.shpshppAh.puhp.phppp.......ppslLslIDaSpPSsccRhaVhDlcpc+lLapshVuHG+......sSG......p.ph...A......spFSNpssShpSSLGhahTt.ps.Yt..G.cpGhS.L+..LpGLEpGhNDpAccRsIVlHGAsYss......s..hl........p.p.h......G.+LG.RShGCPAlstp.lsc...p...lIstl...KsG...s...llahY..............................................	0	47	79	102
+13488	PF13646	HEAT_2		HEAT repeats	Bateman A	agb	Jackhmmer:C2M4W3	Family	This family includes multiple HEAT repeats.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.37	0.72	-3.70	323	11825	2012-10-11 20:01:04	2010-12-08 13:16:31	1	572	2216	18	5662	13686	1691	88.30	20	24.50	CHANGED	h.p...hLhp.h...L..p......ss..ss...t....l.+.t.t.uh.psLu.............p.h..t..s..t............ps.............................hshLh.p.hl........p..s...s..s....s..t.....lRttAs..p..uL....u....p..h............s..........s.....s...p....s....h.....s.hLhp.......h..h.ps..s..s..s..t...h.hR..ts..s...hp...uLt	...................................................................................................hhth.l..p.......st..s....t.......l..R....t..t..As.tsLu....................................p.h...t....s..t...............ps..............................................................................................lshLh...p..hL..................p...D.....p....s.....s..t..........VRttAs..t.....uL............u......p...l.................................u.............................s.........t..p...........s.......l...........s..hLh.p.............h...h...ps...p..t...............hp..................................................................................................	0	1805	3521	4730
+13489	PF13647	Glyco_hydro_80		Glycosyl hydrolase family 80 of chitosanase A	Naumoff D, Coggill P	pcc	CAZY:GH80	Domain	This is a small family of bacterial chitosanases.	25.00	25.00	616.50	616.40	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-11.95	0.70	-5.16	3	15	2012-10-02 14:50:22	2010-12-08 13:22:11	1	1	13	0	0	15	0	297.50	91	89.83	CHANGED	AAAAAGVIPVGDSRVYGNVFDKGRKLTVNQWQAVLSMDAYPENGTTNYQDPEPWRYCEVDYEAuEGISDYRGDTFGPVGVTTVGDFPDYFKNAYAPYVLGKTGATNTDMKNWGVQVTGIAAADMKADDTRLDPYPNLSRSNSKKRAALTKICQALQSDFDNRQAQYVMSHYAHIDSDKLLPVLDALKKIGFTSFuQYNLVGLAFQVQVNTGSIGSISAFSSVKSAGNCGSMSuETCFATYLTDQYIRWLKSSSLGDDsGNCWRASMALDIYKQDPTMGNVSVVTSIINSKYPNNSGKCPTSGVKWSKN	..AAAAGVIPVGDSRVYGsVFDKGRKLTVNQWQAVLSMDAYPENGTTNYQEVGPWRYCEVDYEAAQGISDYRGsTFGPVGVTTVGDFPDYFKKAFAPYVLGKSNATNADMLAWGVQVTGVTAGNFpADDTALDPYPS+SRSDKsKRAALTKICGALQSAFDTQQDKYVMSHYAHIDQDKLVPVLNALKGIGFTAFDRYNLVGLAFQVQVNTGSIGSISAFSSVKSAGNCGSLSAETCFATYLTDQYIRWLKSSSLGDDPDNCWRASMALDIYKKDPTMGSVSVVNQVINASYPGNSGKCPTSGIKWSKN.	0	0	0	0
+13490	PF13648	Lipocalin_4		Lipocalin-like domain	Bateman A	agb	Jackhmmer:C2M763	Domain	\N	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.97	0.72	-3.41	116	502	2012-10-03 08:47:39	2010-12-08 16:03:31	1	7	182	0	164	533	83	115.20	14	70.75	CHANGED	hhsu.Cus-..-c.....ps.............pss............................lh...G....s.Wpls....p..h.s........tts.t..............................t...ts.h.........sps.ptshhpap..s..s........s.hstt..php......ss.......t.th.t..t..............tpsssasls..ss......pl.slph..............pss..t..t...tp.......hp..hhp......l....s..sspLsh	................................hhuCssc..cs.....ps.............pss............................lh...G....s.Wpls...ph.s.........httt...........................................p..tth.........sps...ptsthpFp..s...s............s..hstt...php......ss.........h..t..t..................................ppstsaslp..ss......pl.phph....................t.p.s..t.................h..hhp......h..s..tpph......................................................	0	68	136	164
+13491	PF13649	Methyltransf_25		Methyltransferase domain	Coggill P	pcc	Jackhmmer:B1L4J9	Domain	This family appears to be a methyltransferase domain.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.54	0.72	-3.65	78	1216	2012-10-10 17:06:42	2010-12-08 16:37:45	1	39	965	11	462	43237	12860	101.60	19	35.92	CHANGED	lL-luCGsG....h..h.tt....hhpt........................h....t................hphhs...lDhspctl..........................ph..sp....................cph..........h........phc.h......ht.....sch......pp.....l........s..........h........ttt..pFDhlhs..................sh.hs.........h.hsptthhphhpchsp.hh..c..s.G	............................................................................hLDl.uCG.s.G....t...h....h...th....h.h.t....................................................h.....t..................tph..hs......lDl......s...p.......p.h..l......................................................ph....up....................................................................pph..................................pl.p...h......lh...............u.Dh......................pp.........L.............................................s............................h.....................tst.....sa.c..l....l.hh...............................................hs.t..hs..................h...h.....t..........p.....p......h......t....t..h.h.p.....ph.h.p.h.l.t.t...............................................................................................................................	0	133	259	371
+13492	PF13650	Asp_protease_2		Aspartyl protease	Coggill P	pcc	Jackhmmer:C6QGC6	Domain	This family consists of predicted aspartic proteases, typically from 180 to 230 amino acids in length, in MEROPS clan AA. This model describes the well-conserved 121-residue C-terminal region. The poorly conserved, variable length N-terminal region usually contains a predicted transmembrane helix.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-10.02	0.72	-3.48	300	2359	2012-10-02 15:32:34	2010-12-08 16:43:30	1	147	973	0	1248	4331	281	91.40	19	17.90	CHANGED	l...sspl....s.G......p..s...h...phllDTG.A.o.t..s.sls....pp..hu....c.p.l.....u.l...ph..t..sh.t............ht.s..p..s...u..s.G......p..s.p.s..t.h...s.p.ls...p..........lp..l..G.s........h.p..hp.sl........p.......s.hl.hs.............s.....t.....h...s........s.......ul.......LGhsh	.......................................stl....s..G......p...s..h...phllDTGA.s.s...s.hls....ps...hs....c.c.l..........u.l...ph..p..s..h......................hth.....p..s...s..s.G...........p..s..p...s....t.h...s.p.ls.....p.............................l..p..l...G..s.................hp...h.t...sh........p..........h..hlhs........................................t................p........slLGhs...........................................................................	0	480	794	1052
+13493	PF13651	EcoRI_methylase		Adenine-specific methyltransferase EcoRI	Bateman A	agb	Jackhmmer:C2M8X9	Family	This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.	22.60	22.60	24.20	24.00	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.13	0.70	-5.36	12	164	2010-12-08 17:00:59	2010-12-08 17:00:59	1	6	134	0	31	164	89	237.20	38	88.75	CHANGED	psLpcA+pu..KsDEFYTphsDIEpElpaYhpa....FcsKsVLCNCDDPhcSNFhKYFAhNFspLGLKKLIsTsYusss.........................s.......phs..........ps......csp.pshhh..-h-.t..s..psschs...............schphphLpGsGDFRSpEslcLLc-uDIVVTNPPFSLFREaluhllcYcKpFlIIGN.NAITYKElFsLI+cNKlWLGhph..GchtFtVPDtYE.....ctTchhlDEsGp+apphuNspWaTNL-ht+RH.EsL.Lh..........++Y..tc....cpYPKYDNYDAIpVs+sp-IPhDYpGlMGVPITFlcKYNP-QFEIlG.htps..t...............................h.h..ss..cpc.h....hlNG..K...phYtRILI++K	.......................................p..LptApt...KpDEFYTph.-IcpEhthY...ph....FtsKhlhhsCDD........s..........Ss........FhhaF..pFtthtlK+Llsspa................................................................................................tt..h..htts.....GDFcStEshp.lhp.p.uDIllTNPPFShFcEals.Lh.ch.pKpFllluN..NulT.YpchF.LlppN+hWhGhth..u...FhlPpth.........tt.t.h....ct........G......t.hhp.tshhWhTNl-..hRp..p.l.Lh..........pph........ptY.hYDsa.puIpVs.h.tIP.Da.G.MGVPlo.Fhp+asP.pQFcllt...t........................................................................t...................ps...p.......a.Rlhlp...................................................................................................	0	6	20	24
+13494	PF13652	DUF4146		Domain of unknown function (DUF4146)	Coggill P	pcc	JCSG_target416819	Domain	This is a family of short proteins which appear to be pre-cursors. All members are from Pseudomonas spp. The function is not known.	21.80	21.80	22.40	180.80	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.21	0.71	-4.25	11	61	2010-12-08 17:32:18	2010-12-08 17:32:18	1	1	61	1	15	44	4	112.00	72	81.75	CHANGED	ASLpEaELs+MLEKVA+ESSVGTPRAINEDILDQGYTVE.GppLlNHLSVRpuHAppMRuNPcsVRsQLGsSVCpNsGYRpLMuKGAVh+YcFTEYKTN+PVsoppFsuuDCs	.AShp-FELSKMLEKVAKESSVGTPRAINEDILDQGYTVE.GNpLINHLSVRpuHAppMRuNPDsVRsQLGsSVCpNsGaRQLMu+GAVLpYpFTEYKTNpPVATppFpAusCp.	0	1	3	10
+13495	PF13653	GDPD_2		Glycerophosphoryl diester phosphodiesterase family	Coggill P	pcc	JCSG_target396624	Domain	This family also includes glycerophosphoryl diester phosphodiesterases as well as agrocinopine synthase, the similarity to GDPD has been noted [1]. This family appears to have weak but not significant matches to mammalian phospholipase C Pfam:PF00388, which suggests that this family may adopt a TIM barrel fold.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.92	0.72	-7.25	0.72	-3.66	73	257	2012-10-01 22:17:21	2010-12-08 18:04:34	1	7	110	10	44	1089	478	31.20	49	10.52	CHANGED	+VhhW.os...........Dp...............s.........sh.........pphh.shGVDtlhTspss	....KVYaW.Tl...........DK.........cu.....oh........RcuL.cAGVDGlMTNaPs...	0	17	31	38
+13496	PF13654	AAA_32		AAA domain	Coggill P	pcc	Jackhmmer:C6QHL0	Domain	This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	25.80	25.80	25.80	26.00	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	509	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.64	0.70	-5.84	125	1541	2012-10-05 12:31:09	2010-12-09 13:32:27	1	8	1299	2	408	1140	169	341.70	25	52.08	CHANGED	Tp-L.ssh.....pt.hlGQcRAhcAlcFGlul.cppGYNlalhGtsGoG+pohlpphLpctA...cp...ssPsDWsYVtNFcsPcpPtsLpLPAGpGpphccDhcpllcpLtpslPpsF-u-cYpp++ppltcpappcppphhpplpcpApcpGhsL.hpossG....hs....hs.Plp...........-.G.........cs....lsp--a......ppL...............sccc+cplc..pphppLppclppllpp.lpph-+chp-clccLc....cclst.slsphl....p....pL+....c+Ypc...h...sclhpaLcslpcDll-Nlp.Fh...............t.tp.......tt...tpt..p...................RYpVN.l.lV.DN...s.......................pppGAPVVhEssPoapNLhGcIEatsphG.slhTDF......ohI+sGuLH+ANGGYLllcAcclLppPauW-uLKRAL+opclpIEsh.....ths........so...h......oLcPEPIPLclKVlLlGs..lYaLLtpaDs-FpcLFKVpADF-schsRss-shppaAphlushsccpsLh.h-+sAVA+l..lE..au..uR.....spc..+..LSs+hspls-LlpEAsaaAptpssphlpspaVcpAlpt+phR	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sphtpLhGp.lc..s..............s..s.h........h...l..pPGhlHpANG.GhLllshpsLLspP....h.....h....W.tLKphlppcchc.h.uh.....s.s......pslslps.sh..P..LclKlILlG-.ccthtt...hpch-P-.ht.c.hht...lh..u-F-.cplp.h.s.s.E.s.h.p.p.a.spalsp.hsp.c.p.p.L..sh.st.s.AhstLlctusR..h......spc...p..LsLp.......l..tp..hl.t-.us.hs........t..............h...p..tl..s.......................................................................	0	112	246	345
+13497	PF13655	RVT_N		N-terminal domain of reverse transcriptase	Coggill P	pcc	Jackhmmer:B3CUZ7	Domain	This domain is found at the N-terminus of bacterial reverse transcriptases.	27.00	27.00	27.20	27.30	25.80	26.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.72	0.72	-3.92	152	753	2010-12-09 14:12:41	2010-12-09 14:12:41	1	5	321	0	163	711	23	79.10	44	18.14	CHANGED	Wp.........sIsWpplccpVh+LQpRIhKAsppGchp+V+pLQ+lLh+..SasAKhLAVRRVTp.Np..............GK+TuGVDGhhhho....Ppp+hphhpp.....Lp	...................WpsIsWpcspppVh+LQpRIh+AsppGphtKV+pLQ+LLs+..SahA+hLAVRRVTp.Np..............GK+TuGV.DGhhh.o....spp+hphhppL................................	0	42	115	138
+13498	PF13656	RNA_pol_L_2		RNA polymerase Rpb3/Rpb11 dimerisation domain	Coggill P	pcc	Jackhmmer:B1L7Q7	Domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer.  The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000).  Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037).  Rpb11 is found as a continuous domain.  Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.	27.00	27.00	27.00	28.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.35	0.72	-4.54	53	756	2012-10-02 13:35:44	2010-12-09 14:24:54	1	6	450	90	495	763	147	75.70	37	58.93	CHANGED	sphphplpsEDHTLuNsLpphLhcs.scVpFsuYsl.sHPh........pschpl+lpoc..ss.........sshcslcculpclhshscplpppa	.............sspFplpcED.HTLGNhLRhhLh+..........s...P........pV.F.uGYpl.PHPh.............-s+hhlRlQTp..ssh........................................ssh-AlppulpcLhs.hshlpcpF...................	0	149	262	401
+13499	PF13657	Couple_hipA		HipA N-terminal domain	Bateman A	agb	TIGRfams	Domain	This domain is found to the N-terminus of HipA-like proteins.  It is also found in isolation in some proteins.	22.50	22.50	22.50	22.60	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.44	0.72	-3.70	185	1769	2010-12-09 14:38:03	2010-12-09 14:38:03	1	10	1109	8	541	1574	195	102.00	24	26.72	CHANGED	LpVhlp.s....p....hlGpLp..p.s...ss....s.....hpFpYsssahs....s..uh..sl..S.l....sh......Plp............sp.................s.a..........p......s..........p.......sl.s.................aFssLLP-uh....hpc.....hl.....sp.....p..h.....phs.....sts..shsl.....L.thlG.p.-.shGAlphh	................................hht..s......p.....hlGpLs...pp.......ss..s.....hpFpYss....palt....t......uh..sl...S...l....sL......Plp..............pt.................sh..................p...s.....p......slhs........a..FsshL...PDuh......hRc.....hl.........tp...c.h..............php.........stsshsh..........L.thl.G.p.c.s.hGAlph.h..................................	0	136	313	436
+13501	PF13659	Methyltransf_26		Methyltransferase domain	Bateman A	agb	Jackhmmer:Q9YEM1	Domain	This family contains methyltransferase domains.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.74	0.71	-4.06	167	9512	2012-10-10 17:06:42	2010-12-10 15:35:54	1	120	4267	26	2887	64631	10679	155.40	18	26.58	CHANGED	ss......plL-PusGsGt.h.h..thhh.pt................................................h........sphhul.El.ssh......................................................................ssph...sp............................th.....h.t............t...t....h.............................................................................................................p....hhtsc.h..t.ph.....................................................t.....h....t.s.....s.p.............h-hlltNs.Pa...................s.....t...............t.t.........t......t...........................................................................hhp...............th.l..tps.hc.hLpsu.Gh.lshls....s.......s	...................................................................................................................................................................................................................t..pllDh.us...G....o.G.s....h..h....lhhs..pp................................................................................................................h........tsplhul.E.l.....s.s.t........................................................................................................................................................................................................................................................................................................................................s.s...p.h....Ac........................................ps......hth................s....t..h.........................................................................................................................................................................................................................................................................................................................................................................................................................t....t.......h..p........l...h...p..s..D...h.....h..ph..................................................................................................................h............h.......t..s..........s...p...........................hD....l...l...l....s...N...P...P.Y...........................................h..t.t.........................t....t..t.........t...t......p................................................................................................................................................................................h.hp.................th..h...t...t.u..h.......p...h.L...p............s...Gh..hshh...p............................................................................................................................................................................................................................................................................	0	966	1897	2456
+13502	PF13660	DUF4147		Domain of unknown function (DUF4147)	Coggill P	pcc	Jackhmmer:B9Z5Y2	Domain	This domain is frequently found at the N-terminus of proteins carrying the glycerate kinase-like domain MOFRL, Pfam:PF05161.	23.00	23.00	24.90	24.70	22.30	21.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.53	0.70	-5.26	229	900	2010-12-10 20:10:12	2010-12-10 20:10:12	1	9	749	3	400	860	424	223.20	39	52.89	CHANGED	phlpplFcuAlpAupPtpsltptLst..p.....................................s...tG+slVlGuGKAussMApAs.-phh........ss.........p......l..p.GlVlT+a.........Ga....s..t..........s......h...p......................p..l...cllE...Au.HPVPDpsulpAuccllchlp.....s.l.stcDlVlsLlSGGGSALLshPss........GloLtDKpslsctLLpSGAsIsEhNsVRKHLStlKGG+LAtss..tP..A..cVloLllSDVsGDc..s.sI.......A.......SGPTlsDs..o.ThtDA..hsllc+Ysl...plPs..s.ltphLpps	..............................t..hpplapsAlsAspPttsltttLs.p.......................................spu+slVlGsGKAussMAtAh.Ephh........ss..........p.l...p.GlVlT+.a.........Ga..s..s.......s.....s.p......................................cl..cllE...Au.HPlPDtsulpAupcllphlp.....s..L.s.t.cD....lVlsLlSGG.GSALLsh.Ps.t........GloL.........p-cpsls+tL.LtSGAsIsEhNsVRKHLSt.lKGG+LAtus..hP..A..pVl...oLllSD....VsGDsss.hI.......A.......SGP.T....VsDs....o.o.....h.....t-....A..htllc+Ysl...plPt..slhthLpps................................	0	128	241	326
+13503	PF13661	2OG-FeII_Oxy_4		2OG-Fe(II) oxygenase superfamily	Bateman A	pcc	Jackhmmer:B8H030	Domain	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.35	0.72	-4.34	39	165	2012-10-10 13:59:34	2010-12-13 14:17:58	1	7	132	0	81	1691	1412	68.40	19	21.49	CHANGED	hsshhsst...............h.hhthtpsshhphHhDtpstts.......................huhllYLs...thsscasGuphhh.cpssptt	......................................................hht........................thhphstu.tp.hshHhD.s.sstts...........................h.hohllYL.s........t.ts-at.....GsphhF.c.ts...h.................	0	36	64	72
+13504	PF13662	Toprim_4		Toprim domain	Bateman A	agb	Bateman A	Domain	The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.42	0.72	-3.97	195	9626	2012-10-01 21:47:57	2010-12-13 14:48:10	1	67	4702	9	2135	8279	5737	85.30	27	20.04	CHANGED	stlhlVEGhhDllulcps...shpsshts.......lG...ssl...shpplt..phph................................pclllshDsDh.........sGppsutt....htc..........h..t.shplshls	............................................................t.plhVVEuhhDVhA......l....cps.....sh.........p..s...th.t.s.........................LG.....ssl.......sh..-t..lt.....chth.....................................................................................pclIlsh.-sst............................sGcssAhhhhc.........hhh....shth...................................................................	0	703	1405	1799
+13505	PF13663	DUF4148		Domain of unknown function (DUF4148)	Coggill P	pcc	Jackhmmer:A9BSV2	Domain	\N	22.10	22.10	22.20	22.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.95	0.72	-4.12	203	1134	2010-12-13 15:52:52	2010-12-13 15:52:52	1	3	104	0	396	1029	56	61.00	30	62.98	CHANGED	ussl..ssshs..........uh..A.ps.............s...lTRAQV+AELhphcpsGh...Ps...ts.s......Y.Pssh........p...s.Aps.plss	................................................hs...h..sssss..........................uh..utps.........................slTRAQV+uELsphcpsGh....tss....ssps.......Y.Pssh........ts.Attp........................................	0	20	104	254
+13506	PF13664	DUF4149		Domain of unknown function (DUF4149)	Coggill P	pcc	Jackhmmer:B9YZD8	Domain	\N	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.27	0.72	-3.95	178	975	2012-10-01 21:57:53	2010-12-13 16:57:40	1	3	879	0	341	687	671	99.80	23	53.21	CHANGED	LhhuhhhGuhhhhu......als................uPhlFps...L.....s+t.psGtltspl................Fshahh....hthsssslhhlhthhth.............h.t..t..hhthhhlhshhlhslhsthhltPhhsphptpttp	...................................hshhhGu.lh..hs......a.ls................u.hlFhs........L..........s+h.psGphtspl.................F.hhhh....lhhsssllhh.hhhhhsh.......................t..h...h.hlllshh.lhslhshahltPhhtphpptt..t............................	0	84	194	285
+13507	PF13665	DUF4150		Domain of unknown function (DUF4150)	Coggill P	pcc	Jackhmmer:A9BLL6	Domain	\N	27.90	27.90	27.90	29.30	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.34	0.72	-4.16	83	382	2010-12-14 12:40:17	2010-12-14 12:40:17	1	24	235	0	135	304	15	106.30	32	34.40	CHANGED	sGhsh.uhPDVChT..P..........lPlP..YPNhuhssssh.s..sstsVhhsGtPshshs.ohh.shosGDp.uGss..tGVhSGslhGtschh..stS.sVhhcGpsssRhsDhshpN....ssNssGt	..........................hsh.shPDVChTPs..s......lPlP..YPNhAhssssh.s..ssssVhhsG.ts.shshs.ohh..shosGDpuGst.........tGVhSuT.lpG..p..schh..stSssVhhpGpsssRhsDhshhN....ptNs.s.h..............................	0	35	71	104
+13509	PF13667	ThiC-associated		ThiC-associated domain 	Coggill P	pcc	Jackhmmer:B9Z987	Domain	This domain is most frequently found at the N-terminus of the ThiC family of proteins, Pfam:PF01964. The function is not known.	27.00	27.00	27.20	27.20	25.80	26.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.80	0.72	-4.42	217	1951	2010-12-14 13:42:45	2010-12-14 13:42:45	1	4	1913	6	496	1521	213	79.30	48	12.96	CHANGED	tshPsS+KlY.lpGs..+sDIRVPMREIsLosT.............s.........pt.....NsPlhVYDTSGPYTDPsspIDlcpGLP.plRpsWItcRuDsEp	..................t.saPsS+KlY....lpGo....ps-..l....RVPMREIpLosT.h..t.st.........ptNtslsVYDTSGPYoDPph..t.....IDlppGLs.cLRpsWIptRuDsE.............	0	124	292	401
+13510	PF13668	Ferritin_2		Ferritin-like domain	Coggill P	pcc	Jackhmmer:A9C0V0	Domain	This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.60	0.71	-4.22	124	660	2012-10-01 21:25:29	2010-12-14 13:44:48	1	9	316	0	446	1025	61	140.50	24	45.49	CHANGED	sDhclLNaALsL..EaLE..............spFYptu.htt.............................sushsssh.....hshhpplttcEhuHlchLpssl......Gsps.......l......sps......pa.....ca.............................hssas.s.......ttsaLtsAtshEssGVsAYhGAus.hls...sts....hLpsAuuIluVEAtHsuhlRshltp	....................................................DhplLphALsL..EalE..............t.saYptuhtths..................................tsshssts.....hphhpphsppEhuH.sp...h.Lpssl...........Gsps...............s..........sps..........p.a.....sa.................................................................shs.s........stsalt.h.ut........hl..Ep..sGsuuY...hG...sss...hls..........sps....h...hp..hsu...slls...sEApHtuhlRph.....................................	0	159	312	398
+13511	PF13669	Glyoxalase_4		Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	Coggill P	pcc	Jackhmmer:A9C2R0	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.42	0.72	-4.04	77	2150	2012-10-02 15:00:03	2010-12-14 14:45:10	1	24	1580	20	829	7043	2394	114.10	24	65.97	CHANGED	pplulsVt...Dl-pshpha...sphlG............h........p.....h..............h..........t.p.h........h..s.............p..............s..............p................s..............s........s..h.........s......h.h.th.sss.....hpl..ELl.p.....Phs.....ss.....s.hpt.......ptsu.lp..Hl.uhh..s...c...D...l-ssltthpp.p..Ghp..hh....t.s...tt..u...s.s.s.tc.hsa	.................................................................pHluluVt...D..l-pAhphaps...hL...G.............h............p......h.......................h...............t..t..................t..s......................p............................p......................p.....................s.................................V....................c...s.........................s..........h...l...th...s.ss.................pl...E.L.l...p........Phs.........ss.......................phlpp...........................pusG.l..a....Hl..Aac......V....c......D....l..c...s...s...h...p...c...Lcp...p....G.hc..ll.....tp..t..sph..G...s.t.s.t.lha................................................	0	282	568	711
+13512	PF13670	PepSY_2		Peptidase propeptide and YPEB domain	Coggill P	pcc	Jackhmmer:C6QGP5	Domain	This region is likely to have a protease inhibitory function (personal obs:C Yeats).  The name is derived from Peptidase & Bacillus subtilis YPEB.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.78	0.72	-4.08	83	928	2012-10-01 23:09:26	2010-12-15 11:13:51	1	7	550	0	229	873	47	80.40	22	77.90	CHANGED	hhhlshssshhu...usAhA.........sspsPtspWh..stsplpptlpp.pGa.plcclcht-sts...aElc.uhspsGc..+hElhlDPtotpllcpc	...................................................................hh...hhhhhhh.u...........ssAhA...................pstt..s...sph.............shsps.tp.h...l.pp....pGa..plpclch..-...c.us...........YElc.s..ts....p..sGp..ch-lhlDstohcllp..................	0	52	120	174
+13513	PF13671	AAA_33		AAA domain	Coggill P	pcc	Jackhmmer:A9BWH5	Domain	This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.74	0.71	-4.31	146	4032	2012-10-05 12:31:09	2010-12-15 11:19:46	1	83	2093	32	1521	12436	3403	138.60	17	34.96	CHANGED	lllhsGhsGSGKooh....spp.h....htth....s........hhh.lspD.s................................h+p..phhs..........tt.t.....p..................................t.......th...sht....hhhphspthL.ptG...ts.s.ll......D.sT.........slp.....t.ppR....p.thhpl..Ap..phus.............h.ph.lhhpss..phhtpR...............tpRptp.................p......ssttslpphhpph..c..P	.......................................................lllhtGhsG.oGK.oTh................ucp...l....................ttt.hs.......................hhh...l.s.p...D.s.....................................................................................hpp....phts................tt.........t...................................................................p.......ht..tt.........s.h.p..............h...h..h.......p....h...s...p..p......t.......l........p...p...G..........ps...l...ll.................D...ss...................................................hp...........t..pt.p...................p...th.h.p..h......sp.......p....h..s..h.p.....................................h..h.h...l.h..h...p...s.....s.......c.h.h.h.p.R.................................h..t.t..R..stt......................................h.....h..................................................................................................................................................................................................	0	467	898	1220
+13514	PF13672	PP2C_2		Protein phosphatase 2C	Coggill P	pcc	Jackhmmer:A9C323	Family	Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.58	0.70	-4.93	68	3942	2012-10-03 01:39:20	2010-12-15 15:10:55	1	30	2499	16	1091	5760	566	219.60	18	65.13	CHANGED	tGpoHh.ppu..tssQDsht......htth.sss...hl...l..A..VADGAGS......u..p..hSchG....uplAsp.ss.....h.ptlpphh.................sptphs...............t.pthhp...plh..pphht.......................................psttp....pt...phpchuoTLlhsl....hs.......s....s.h.......hh..hhplGDGsl.shht.........ps..uph.ph..lsp......s.c...s......GEa.s...Np...............TtFlsss....sshp.ph.......................................phhphp...h.pth...sslhlhTDGlp..........s.sl.....tstp.........sahs.hhpth...hpt...h..spst...........hppp...LtphLp	............................................................................................................................................................................................................................ht...............t..NpDthh.............t....ttt.............l......h......s.....lADGh....GG.........p..p........sGc.h.A............S...ph...u..lp..ph.........h.p.h.h..p.p.ph...............................pttt.t....................................................h.pth.hp....tht....pp.ht..............................................................................................................................pt..tt.p...........pt.....ph.p.s..h..u....T....Tlsshl........hp.....................s.........s.p..................hh..hsplGDSRs.....hhh..................cs......s..p..l.....pp......l..op.....................D..+...........s..................................h.th..s.......sp...................................tt.t.l..s.tp.........p.s.t....ph..............................................................................................c.h.t.php.....h.p.ts....-.h..l.l.L.s.SDGlp...................s.hl........sspp..............h..................................................tht.thttt..t.......................................................................................................................................................	0	376	772	985
+13515	PF13673	Acetyltransf_10		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:A9C0U2	Domain	This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.18	0.71	-10.45	0.71	-3.97	46	6639	2012-10-02 22:59:21	2010-12-15 17:48:46	1	97	3051	5	1600	44588	6348	116.40	17	61.61	CHANGED	Dhstltplhpc.shps.p.s.h.hh.s....tth.......h..s.l.....cphhpp..s......hhhlh.hss.....pl.....s..ua.....s.t......h...p....s...ssc.......lsh.....L..hstsphptpGhupsLls.tltp.th..pp...uhp..hLpsp.......ushhu...psh.ap+.hGa	.......................................................................................................................................h......................................................h........................p...h.............p.p..h..l....t..p.....................h.h...h....l...s.....p....p...s...s..................................p.l...............l.....G.a..................h..s....................................l.........p...........t.........ptp.............................................lst...............l...aV..p..P.p.h..p..t..p..G....l....G....p....t......Ll........p....t....h.hp....t.h......tp........tht.......h.l...p.lp..............ss.......tA.........hs.F....Y.p.c.hGF............................................	0	480	972	1299
+13517	PF13675	PilJ		Type IV pili methyl-accepting chemotaxis transducer N-term	Coggill P	pcc	Jackhmmer:Q47EX4	Domain	This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP, signature towards the C-terminus.	23.00	23.00	23.10	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.61	0.71	-3.75	504	2034	2010-12-16 09:58:11	2010-12-16 09:58:11	1	65	1235	6	420	1339	56	110.10	25	20.36	CHANGED	uh..hh...lt..ust..ssA.cAINhAG.SLRMQSY....RL...h......h.h.....st.u.....p.t..hh...p..thppsht..p.sh..tp......Lpptsst..................s.s.l.psph........tp........Lpp.pW.....pc.lp....s..tl......pp...spp..................tt...shpsh.ssp....ls	.................hhht.sst.tsA.cAINhAGSLRMQSY....RL.......s....................h.h.................st..u..........p...p...t...hh.....p..thpps..ht..p.sh...sp........Lpptsst..........................psl...psph..............tt........Lps..W....pchp....stl..........pp....spt....................httslsphlt...................................................................................................................................	1	105	246	341
+13518	PF13676	TIR_2		TIR domain	Coggill P	pcc	Jackhmmer:Q47BW0	Domain	This is a family of bacterial Toll-like receptors.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.24	0.72	-3.87	214	2056	2012-10-02 18:56:14	2010-12-17 13:44:38	1	344	944	8	1033	5257	266	109.00	18	21.07	CHANGED	lFlSYs..t...p.D..pt...hAchl...ttt...L......p....p..t....Gh...p...Va...h..s......h.ch.h...s...Gssh..hptlpps.l...p.p..uphslsll.Sssah....p.S............s..asp..p.E....hptA......tp......ts......+...llPlh.......lc...s.s........ph...ss....h.ls....plts.....hc	..................................................lFlSas.....p........p..D.........pp..........h.s.....p.....t.....l.....t.pt....L.................p...................p........t........Gh.......p..................sa......h..D..............p.sl..t............s.......G..p.s.h........tpp.......l.p...pu...l......p.p...uc.....h..hlh....l.l..S..sshh....p.s.....................p...aspp..E.....httu..................hp.............ts..........c.....llPlh........hp...s..h..........th................................................................................	0	444	754	932
+13519	PF13677	MotB_plug		Membrane MotB of proton-channel complex MotA/MotB 	Coggill P	pcc	Jackhmmer:P45443	Domain	This is the MotB member of the E.coli MotA/MotB proton-channel complex that forms the stator of the bacterial membrane flagellar motor. Key residues act as a plug to prevent premature proton flow. The plug is in the periplasm just C-terminal to the MotB TM, consisting of an amphipathic alpha helix flanked by Pro-52 and Pro-65, eg in Swiss:D3V2T1. In addition to the Pro residues, Ile-58, Tyr-61, and Phe 62 are also essential for plug function [1][2].	24.00	24.00	24.00	24.00	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.89	0.72	-4.65	1028	2913	2010-12-17 16:12:36	2010-12-17 16:12:36	1	5	2048	0	745	2094	570	56.70	30	19.45	CHANGED	h..hh+.+.p......t.tt.sppssuWhluYADFhThhMAFFllhahlSssstpc...........hptluphFpsshs	..................h..h++p......t.pp.stttssWhlsYADhhThhhAFF...llhahh..St.ss.p.c...............hptluphhpssh.s.......................................	0	250	484	613
+13520	PF13678	Peptidase_M85		NFkB-p65-degrading zinc protease	Rawlings N, Coggill P	pcc	Jackhmmer:B7UNX4	Family	This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65 thereby down-regulating the NF-kappaB signalling pathway [1]. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.	21.80	21.80	22.50	62.20	21.30	19.20	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.66	0.70	-5.00	8	95	2011-01-11 13:03:09	2011-01-11 13:03:09	1	1	85	0	1	39	0	246.90	84	71.65	CHANGED	sppppDsYA-YVlspGpRt..pLSsspLsslh.sVp+AVppShupLlDcHTAhAIEsTlh-ALhpSpTFRcAVuFul+pc+psLGh........IpYRN.YEls-pops+hpclpplohsEIhpSsAspsPIls.h.sE.AsE--s.pcP..aVsISlAPshsStcYPhWQpuLIHEIIHHlTGAuDP..t-s..RlGPTEILApRlApELsWsI..Pp....FpuYssP-RlpAlppRsFpuLhcslhRHcpctptllpRLssIucthcASP-	............PNRAENAYADYVLDIGKRI..PLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEcVHIGC........IKYRNEYELNEESuVKIDDIQSLTCNELYEYD.VGQEPIhP.I.CE.AG.ENDN.EEP..YVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPS.GDSNIELGPTEILARRVAQELG.WSV..PD....FKGYAEPEREAHLRLRNLNALRQAAMRHE-NERAFFERLGTISDRYEASPD.....................	0	0	0	1
+13521	PF13679	Methyltransf_32	Methyltrans_27;	Methyltransferase domain	Coggill P	pcc	Jackhmmer:A9BXC4	Domain	This family appears to be a methyltransferase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.98	0.71	-4.50	63	1223	2012-10-10 17:06:42	2011-01-12 13:55:34	1	19	861	0	577	1525	252	151.10	24	34.50	CHANGED	+Kh+QVp+....hhphlcs...llpph............tpssshsllDhGuGKuYLuFlLh..hhpt.......ssclhGl-s+sclscpupplAp+Ls..a.sphpFhphsltpsh.......................................................................................ssphcllsuLHACsTATDsAlphulp..ppu+hllhVPCCptclspp	..........................................................................................cK.cplpphhphlpt...hht.......................................p...tshpllDaGuGKGYLuhhLth......................t..hshp.lhulE...hc..p......p....l...s.p.t.u..pp..h....u....p.c.l.t.............h.......t...p..h..p...hhp.s..s...hts.h..t.......................................................................................................................................................................spthshslu.LHACss.ho.spslch..s.....l...........p.......t.........p.....s..ph..............ls.....hsPC.Cap.lp..t..............................................................................................	0	197	312	453
+13522	PF13680	DUF4152		Protein of unknown function (DUF4152)	Bateman A	agb	[1]	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in archaea. Proteins in this family are approximately 230 amino acids in length. The structure of PF2046 from pyrococcus furiosus has been solved.  It shows an RNaseH like fold that conserves critical catalytic residues [1]. This suggests that these proteins may cleave nucleic acid.	27.00	27.00	332.60	332.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.53	0.70	-5.34	5	13	2012-10-03 01:22:09	2011-01-12 14:06:31	1	1	13	0	11	17	0	223.80	73	99.79	CHANGED	MRIVSADTGGAVLDEsYEPIGLIATAAVLVEKPYKTAKhSlVKYADPFNYDLSGRQAI+DElhLAIELAKKVKPDVIHLDSTLGGIElRKLDEPTIDALsISDRGKEVWKELSKDLQPLAKKFWEETGIEILAIGKSSVPVRIAEIYAGIYSAKWAIEYA+K..EG+lIIGLPRYMcVEI+-GKIhG+SLDPREGGLYGEIEsEs.EGIcWElYPNPlARRFMVFElW+E	MRIVAADTGGAlLDEsYpPIGLIATsAVLVEKPY+TAshSlVKYADPFNYDLSGRQAIRDEshLAlELA++VKPDVIHLDSTLGGIEVRKLDEPTIDALsISDRGKEVWKELSKDLQPLAKKFWEETGIEIlAIGKSSVPVRIAEIYAGIYSAKWAIEYA+c..cG+llVGLPRYMcVEI+sG+IhGcSLDPREGGLYGEIEs-s.-GItWElYPNPlsRRFMVhEVat....	0	1	1	6
+13523	PF13681	PilX		Type IV pilus assembly protein PilX C-term	Coggill P	pcc	Jackhmmer:A9BNC4	Domain	This family is likely to be the C-terminal region of type IV pilus assembly PilX or PilW proteins.	25.60	25.60	25.80	25.60	24.10	25.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.52	0.72	-3.52	20	47	2011-01-12 14:33:16	2011-01-12 14:33:16	1	2	40	0	20	47	9	97.10	25	40.70	CHANGED	sssth..Psp.tc...suhhhushsp......s..pssppGlCt....tsst........pshWsssc...ts....sshp.s..ps..........s.ssspaGpaT.Gsh......ss.usshlttpts....spssRYhIEhlshts	.........................s....hP....p....ushhushts......shssphppGLCtp...tsst..........pshWssss...hp........ssst.....s.........pstsstYGpFT.Gst......ss.usshL....s......sptsRYhIEhls.p.p....	0	1	13	18
+13524	PF13682	CZB	MCPsignal_assoc;	Chemoreceptor zinc-binding domain	Coggill P	pcc	Jackhmmer:Q47EQ8	Domain	The chemoreceptor zinc-binding domain (CZB) is found in bacterial signal transduction proteins - most frequently receptors involved in chemotaxis and motility, but also in c-di-GMP signalling and nitrate/nitrite-sensing. Originally discovered in the cytoplasmic chemoreceptor TlpD from Helicobacter pylori, it is often found C-terminal to the MCPsignal domain in cytoplasmic chemoreceptor proteins. The CZB domain contains a core sequence motif, Hxx[WFYL]x21-28Cx[LFMVI]Gx[WFLVI]x18-27HxxxH. The highly-conserved H-C-H-H residues of this motif are believed to coordinate zinc; mutating the latter two histidines of the motif to alanines abolishes Zn binding. This domain binds zinc with high affinity, with a Kd in the femtomolar range. Although the function of the CZB domain is not yet known, scientists have speculated that it may function as either an unknown signal input domain, based on its frequent association with signalling output domains, or as a domain that helps to stabilise protein tertiary or quaternary structure.	20.00	20.00	20.20	20.20	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.55	0.72	-3.80	345	1282	2011-01-13 13:31:52	2011-01-13 13:31:52	1	83	938	0	334	896	70	71.70	26	17.09	CHANGED	c.h...-Hhhahppl.hph.lh........ttp..p.pht.scppC.phG+Wa.puts......ppthsph....ss........a.pplcpsHpplHptupphhpt	.........................h.sHhhWhhph.ach.lh............sp...phpp.tsaspC..phG+Wh.pshu....tpphsph......st.............a.ctl.-.ssHpclHpsupphh..h..............	0	135	281	309
+13525	PF13683	rve_3		Integrase core domain	Coggill P	pcc	Jackhmmer:A9BZ80	Domain	\N	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.14	0.72	-4.45	121	4386	2012-10-03 01:22:09	2011-01-13 14:25:37	1	37	1527	0	913	15372	2196	62.80	30	37.29	CHANGED	tulphphhpPGcPhpNualEpFNsph+cEhLstph......h.slscscthlppWhp.cYNppRPHouLGhhTP	......................................tlt.ph.hpsGp..Php......Nu.hhEpast.....ph+.............s.E...h...lstph...................atsh..tc..scp.t.l.tpah........p.hY.Npp...R..PH..p..u..L.shhsP...............................	0	204	552	722
+13526	PF13684	Dak1_2		Dihydroxyacetone kinase family	Coggill P	pcc	Jackhmmer:C9LMG3	Domain	This is the kinase domain of the dihydroxyacetone kinase family.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.68	0.70	-5.49	228	1830	2012-10-02 12:41:15	2011-01-13 14:44:36	1	7	1719	0	319	1574	117	297.40	38	56.58	CHANGED	caGYCTEallphppt.............ch..cph+shLpsl.GD.SllVV..sD-c.............llKVHVHTpcPGpllphuhpa.GpLhclKI-NM+tQ+pphh.................t........................tttp.pp.......ch...ulluVus...GcGl.sclF.cslGsshllpGGQT....MNPSTp...DllpAIcps.sAcplhlLPNNpNIlhAApQAspls...cp....p.lhVlPT+olsQGluAl.lsassst.sh--Nhp.sMp-uhsp........V+oGplThA.VRDTpls...GhcI+cGDhlGl.........h-scIhss...sp-..hhpsshpllcph..ls--u.EllTlhhG.p-sscc.pucp........ltptlccp......a..s.-lEl-lapGsQPlY.alloV.E	....................................................................aGYCTEhhVphpps..........pta-h-cFRs.h.Lspl.....GD.SLLVV.....sD--..............llKVHVHT..-cPGp...V..hphG.pa...GpLhKlKl-NMRp.QHcthl................p.p...........................................................................tptttt.pt.ppt..ph.........ulluVss.......GcGl..s-lF.cuhGsshl.IpGGQT...............MNPSTE........Dll.cA...lcp..s.....sA...c...p.lllL..PN..N.pNIhMA...A...pp...A...A...p..ls........-t.........shVl.o+..o.......lsQ...Gho.....Al.h.....s.....a.....ssst.....sl-.-N..tt.pMspulss.................VtoGplThA.VRD.Tp.l-.....GlcI+csDhlGh...............l-scIlss......ssD......hhpsspphlpcM.........ls-..D....o...E.......I..l..T...lh.hG...cD.uspp...s..p.p........ltph.lpcp.........a......DlElElapGsQPl.Y.YlhSVE..............................................................................................	0	127	230	286
+13527	PF13685	Fe-ADH_2		Iron-containing alcohol dehydrogenase	Coggill P	pcc	Jackhmmer:A0Z2K3	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.73	0.70	-5.07	57	650	2012-10-02 14:41:14	2011-01-13 16:02:49	1	3	514	4	210	15098	4240	260.30	33	66.02	CHANGED	hlupuslsclsphlpch...t.h..p......clhllsDps...ohph...hucpltpsLpptsl...ps.t...hh.........p....s....s......hpsltc...lhpth....t....p....c..s-.....hll.ulGuGpl.DlsKahua...hshPalsVsTAsShDGauSssASlhhp..GhKhoh...AthPhullsDhsllppAPtchltuGhGDlluKhT...A.l...t........DWp..hu.c........th......sc..........l.........sptshp.hl.psh..pps...h.t.....s....p.....c......phl.....ptLhpu....L......s.hu...sluh......S..+PA.....SGuEHhlSHhh......-hh.......h......s.......h.h......HG.pVG	.......................................................................hGpsslp.c.h..u.p.l...lp.ch.....t..h...p.........psl...l..l...s..s..ps.......T.h.tl............s.......G...c....p..l..p..s...s...L..c....s....s....s...h.....ps.h........................ss.p........s..................s..........................h.s.sl.t...p....lt.c.p.h........p....s......h......c.sc...........hllulG.u...Gp.l.D.l..s..K..................h..................A....................u....................h.......................c....................h..................s....................h...................s...................a..................l......s..................Vs.T..............A......A......S....h....D.G...a...sS...s....s...........A...s..lp.t......t.......G...h...K..t.oh..t....s........t.sP...u...l.....lsD.lc.l.....l.....s.s.A......P.p.c.h...h.s.u.GhG..D....ll.......u....K..l..s....A..l....t......................DWh....lAc.....................ch.....sE...........s.l..............s.p.h..s...h...p....h...l...p...s...s...l........cs..s...lp............c..s.c..............c........psh.......csL..h.-u.L................lhS...GlAMth............hssS.RPA.............S...G......u.EH.h.h...SH...hh....-hh...........t.....s.s....hhHGtpVG...................................................................................................................................................................................	0	75	145	176
+13528	PF13686	DrsE_2		DsrE/DsrF/DrsH-like family	Coggill P	pcc	Jackhmer:A5EWY2	Family	DsrE is a small soluble protein involved in intracellular sulfur  reduction [1]. The family also includes YrkE proteins.	25.00	25.00	25.10	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.97	0.71	-4.42	32	864	2012-10-01 20:53:36	2011-01-13 16:37:43	1	15	675	10	260	763	82	149.10	38	44.23	CHANGED	pp++hhllhossh.c..hAhAuaIlAsuAAAhGh-VThFFTFWGLslL++sc.phpl........cpshltphhhhhh..t......hsh.shsGhusthhpthM..............................................Kc+sssoLp-LlchAh-pGV+hlACpMoMDlhGhccEELlDGl.phuGsAsaLpcAt-uslsLF	.........................................................t..p+ssIlhhuG..phD..KAhAuhIlANGAs.AhGp-VTlFFTFWGL.NsL+Kt..p.p.sp.l....c.Kp.hh.t+hFshMhstts.p.....................h.lS+MNhhG.hG.stMh+.tlM...........................+++sls.o.L.pLlc.pAh...-...p...G.lKllACpMoM.DlhGlp.cE.E.L..hD..tV..-huGVusYl.sc.AppushsLF..............................	0	105	187	233
+13529	PF13687	DUF4153		Domain of unknown function (DUF4153)	Coggill P	pcc	Jackhmmer:C9LQV3	Family	Members of this family are annotated as putative inner membrane proteins.	25.00	25.00	25.40	25.30	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.90	0.70	-4.82	46	732	2012-10-01 23:40:40	2011-01-13 16:41:44	1	2	721	0	91	498	28	233.20	38	42.73	CHANGED	lhhGls.lh....lh.ulshLF.hsl......st.pha....h.plh......hhshhhhusshaLuhls....p..p.....p......c...htps..........pt..h.....ph.llpalllPLhhlYshlLah.Yhh+IllshplP.....pGhlu.......hl.lhhh....hh.shlll..hhhhh....p.ppp......+.a.....hpha....h+hhs...hlllPll.l.lhhhuIhhRlspYGlT.sR....halllhslah.hshhlhhhh......p+.pt........p.h.........ls.hsh.sllh.llsshsP.hsshslotpSQhsRlcph	.............................................................................................................lhsGLhWLV....LLLWupLF.......+...LV.........GI.pFF.....s.TLFht........schFhalol..G..Ll..o..ALAV..lL...........u.R....ppp.....h...lcuh.....................p+.L.......ho.LIAsG..LLPLVoL.LsLhFI...h.sLPh.s.G.L.u.u.lu.....c+loA...........As..LLhs.....Lu..h.l.Ll.lhAIV...........p-sp............K.s.......lshh....lRsLh......LlVAPla....l..lAuWALWlRl....uQYGWTsDR....Lhllllhlh..Lsahluhlh............R+.up.........ssh.h.......tthh.lss.L.sLVl.LlLLsSPlLDshRISVNSphARapu.u.............................................	0	35	63	76
+13530	PF13688	Reprolysin_5	Peptidase_M84;	Metallo-peptidase family M12	Coggill P	pcc	Rawlings N	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.66	0.71	-4.38	48	463	2012-10-03 04:41:15	2011-01-13 16:50:21	1	31	230	47	275	3504	182	203.10	22	28.71	CHANGED	ss+plsLl.lssDssasssa..u...s.................spptllshls....sAsslappsh.................s..Is....lsLp...slslsspsssss..................t.sssssshLsph........................sshc...uppps.shuahhhhsssss...u...hGlAal........Gphs............ssss.....sssss...ts...........................hhhtsssp...hplhAHEhGHsaGAsH....Dsssp............tsts.Cshst...............ssss.GpaIMsss.ss........sshsp..FS	....................................................................................................................t..pps.lh.lssD.p....p..ah.pth..ss...c...............................tshphlhp..hls.......................ps.tslh.psh...........................s..ls....htlp..............plp.l.h..s..p..s..s..sp..t..........................................ttss.h.s.sp.phL.p..F..................................................s.p.hp.........t.t.....s.....p..s.....s.l.....u...ah.h........o.h.....p.....s...h...ss............G..............lGLAal.................Gssp...................s.sst.......uuhss.....pt.................................................hs..hh.h..o...tp.s....t.hlhA......HE..lG...........H..saGu.H......Dsss.................................p..Cs..........................ts.ts..upalM.shss.........s.t.FS..............................................................	0	114	164	230
+13531	PF13689	DUF4154		Domain of unknown function (DUF4154)	Coggill P	pcc	Jackhmmer:Q47CB5	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 207 amino acids in length. Many members are annotated as valyl-tRNA synthetase but this could not be confirmed.	24.90	24.90	25.10	25.80	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.64	0.71	-4.59	103	788	2011-01-14 11:37:18	2011-01-14 11:37:18	1	6	728	0	143	407	62	141.30	44	76.62	CHANGED	pct..........pl.c.......Ashlhshhpasc.WP.....ss......s...ss..lp...lClhu.sst..hs.........s.s.Lp...p.h.tspph..ss...c.lpl...........ppl........s..ssst......h..ss........Ccllalupt.p........ttphtplhp.tlpspslLolu-tss.sptGu....hlsLhh.pss+lpFclNlsssp+uGlplsu.plLpLA+p	........................p.....VphhVsGIlSYT+..WPuh......uuP..s+...LCIhu...suc..au.........s.s.Lp...ct.Aspsh..sh...hPlhl...........+s.........p..ptsh......h...us........CsuhYFGsc.o........P.shQh....-Lsc.pas.u+u...LLlIAEp.Ns....EChlGS.........AFCLll.......pNscV+FsVNLDuLoRSGV+VsP.cVLhLARp.....	0	35	89	118
+13532	PF13690	CheX		Chemotaxis phosphatase CheX	Coggill P	pcc	Jackhmmer:A5EYB3	Domain	CheX is very closely related to the CheC chemotaxis phosphatase, but it dimerises in a different way, via a continuous beta sheet between the subunits. CheC and CheX both dephosphorylate CheY, although CheC requires binding of CheD to achieve the activity of CheX. The ability of bacteria to modulate their swimming behaviour in the presence of external chemicals (nutrients and repellents) is one of the most rudimentary behavioural responses known, but the the individual components are very sensitively tuned [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.07	0.72	-4.13	95	880	2012-10-01 19:50:22	2011-01-14 15:54:09	1	12	643	7	333	939	49	97.90	23	51.70	CHANGED	lsu.hluh...sGsh..pGhlhlshspphshpl......s...p.t...l...G....-c....t...ps....pc..pltDslGElsNhIsGss+......sch........uh.....p....hpl.slPpllpGps.htl..phs.............ss.sp.tlslsap	...................sslIGh...sGsh..cGphhlshscphAhcl......s....p.t....h.......G.....pc.........pp.....hs-.s.pssluElsNhlsGssp....shLt.......uh.......s.hcl.usPtlltGps.hpl..p...............t............................................	0	161	258	292
+13533	PF13691	Lactamase_B_4		tRNase Z endonuclease	Wood V, Coggill P	pcc	manual	Domain	This is family of tRNase Z enzymes, that are closely related structurally to the Lactamase_B family members. tRNase Z is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Swiss:Q10155, is targeted to the nucleus and has an SV40 nuclear localisation signal at its N-terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, Swiss:P87168, is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.88	0.72	-4.50	41	279	2012-10-02 15:46:01	2011-01-14 17:05:56	1	11	238	0	197	491	119	61.80	37	7.17	CHANGED	pslossTsDTst.sslhLph-.p.cRYlFGpluEGoQRshsE..p+l+l..uKlpslFLTGph.s...............................................WsshGG	...................hshsotDos...sslhla.h-..p...pR...YlF.NsuEGsQRhhpE..+.+l+l..u+......lcsIFLTths.................................................WsshGG..........................................................	0	71	115	167
+13534	PF13692	Glyco_trans_1_4		Glycosyl transferases group 1	Coggill P	pcc	Jackhmmer:D2BSD5	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-11.02	0.71	-4.01	266	5146	2012-10-03 16:42:30	2011-01-17 13:51:46	1	174	2454	8	1838	35567	12883	141.30	16	28.30	CHANGED	p..hh....hl..Gsh...s..ph....shpsh...l.lp.hh..........l..t.p.......t.......h..s....p....h..p...hhl..h..G.s..........h....s.....s............p.....l..pph........t......sl.p....h..........h..uh...h...........s..c..h.sph...hsp...s.....c..l...s..l......s...P..h.......t.....hss...........s...h.....s.....h.K.lh-hhs.sGhPl..l......s.....osh....s.....hps.h.................h..t.......t..hs...h..h.h..s..s....s......s..pshspslt.ph.hp.....s	..................................................................................................h...hhshh...s.th.....t..psh.phh..lp......h.h...............................tl.....t..p..............................p................................h....s................p.......h......p.......hhl....h..Gt..............................s..s...p.......................p......lpph......................hs........sl..p....h.....................................h..sh..l...............s.....-....h..sp.h....l.s.p.....u...........c...l...s...l.........s.....s...h...................p.........ss..............................s..h....s......h.K.lhE.hhu.sG.h..Pl...l..........s.......osh......s.........hp.s..h.........................................h..tt..........s.ts...h....hh.......s..s..........s................s....pph.hptl.phh..........................................................................	0	731	1269	1619
+13535	PF13693	HTH_35		Winged helix-turn-helix DNA-binding	Coggill P	pcc	Jackhmmer:D2BY08	Domain	\N	25.00	25.00	25.10	25.10	24.00	24.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.44	0.72	-4.19	22	1007	2012-10-04 14:01:12	2011-01-17 14:12:01	1	2	663	2	160	491	4	75.70	59	84.66	CHANGED	DWHsADIIAAL+K+GToLAAlSRpAGLSSSTLANALsRPWPKGEalIAcsLulcPuEIWPSRYaD.psGpll-RchRhR	.............DWHPADIIAuLR.K+G.TShAA.SRcsGLS.S.S.T.LANA..L..o.RP..W..PK..G..EhI..IAcALGscPh.IWPSRYaD.pspphlpRp.h....................	0	10	62	108
+13536	PF13694	Hph		Sec63/Sec62 complex-interacting family	Wood V, Coggill P	pcc	[1]	Family	This is a family of closely related Hph proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER. Cells with mutant Hph1 and Hph2 proteins revealed phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterized. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium [1].	19.90	19.90	20.60	24.00	19.10	19.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.13	0.71	-4.26	7	38	2011-01-17 14:23:41	2011-01-17 14:23:41	1	1	23	0	18	34	0	171.50	38	32.47	CHANGED	pp.pp.hh.DhsSssTGtFSDpMFpss.c....ppp.phsps.ph.pssphpspschsssttttpshstpph.spsh...spsthpphspt..pup.cspp...........t+Shupoh.shD+KRLVsQFLc.SlpsSss.pssppsst.............shpo.Sphshssuhp.p.......................hpsLhYpDLcpsstppppso	................................................................................................pLchpslPshsSspTGhFSDhhFpss.D...............hstu.Sh.cs.plSPK.....psaNsstsh.hushsptphtShsl.......apupcpth.uFpplQupppsp+............+SsusS..F..sh-+KRLVsQFLp.ShtsS.s.sohpppss.t.usshssIh.s.shps.Sphs.sppS............................pSLhYHDL-uSshpcsSs............	1	3	8	13
+13537	PF13695	zf-3CxxC		Zinc-binding domain	Coggill P	pcc	Jackhmmer:A9VEF7	Domain	This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.	22.00	22.00	22.60	22.80	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.27	0.72	-11.41	0.72	-3.77	45	436	2011-01-17 15:42:00	2011-01-17 15:42:00	1	13	129	0	268	393	0	92.60	29	37.05	CHANGED	phhGcFpC..ppC.spsWsSsplhlsh+hh....t.....th................hph+hacQcC+pC..sphppPhh........s.ps.......hs-Rlshchpchsshphpt.............h.t.p.t....tPHppcLCEuC+tG	............thGcF+C..spC..p+pWpSupVhsl.h.................tt.................sphh..hatQpCp.cC....pp..pPph........................p..lpclt.p.p.shpppt...h..t.h................h................tsHcpchCptCpt..................................................	0	64	89	155
+13538	PF13696	zf-CCHC_2		Zinc knuckle	Coggill P	pcc	Jackhmmer:A9VEF7	Domain	This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.	27.00	12.00	27.00	12.00	26.90	11.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.86	0.72	-4.45	5	190	2012-10-03 11:39:54	2011-01-17 17:21:59	1	28	117	0	149	536	7	31.30	45	8.63	CHANGED	P+KsPPPcYLCHLCFpKG.HYIsDCPQ..AsPKuE	...............phPPssYlC+lChpcG.HaIpDCPp......sp.............	0	81	103	129
+13540	PF13698	DUF4156		Domain of unknown function (DUF4156)	Coggill P	pcc	Jackhmmer:D2BXE0	Family	The function of this family is unknown but members are annotated as putative lipoprotein outer membrane proteins.	25.00	25.00	25.10	25.40	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.00	0.72	-4.10	49	839	2011-01-18 10:31:11	2011-01-18 10:31:11	1	1	682	0	94	295	28	93.80	51	79.50	CHANGED	ssphostuppVph.sssps..sppCphLGpVoGopu.sahothhtss..sshhpGAhN-L+NcAAt.hGuNslhhhs.....................spthssssshhGpsYcC	........................S.NpLouAGpsVRl..s-ppP..GuECQLlGosTGpQS.NWhSGpaGpE..uuSMRGAANDLRNpAAA..M..GGNVlYGloSP....opsh.............................LSSFsPTsSphhGQVYKC............................................................	0	14	37	66
+13541	PF13699	DUF4157		Domain of unknown function (DUF4157)	Bateman A	agb	Jackhmmer:C7PSA5	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteristic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.	22.00	22.00	22.10	22.30	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.67	0.72	-3.84	185	470	2012-10-03 04:41:15	2011-01-18 10:44:17	1	49	214	0	257	522	62	74.20	33	11.64	CHANGED	sLsssl+sthEsthG..tD.hosVRlHs...s......tusptspslsApAaTp.GscIhF....s.Gp.tststt..........upclLAHELsHVlQQptu.t	............................................Lstsl+sthEsthG..tD..husV..RlHss.....stusptspslsApA.aTh...GscIhF....s.Gp...ts.t..........spclLAHELsHVlQQppu.........	1	100	177	239
+13542	PF13700	DUF4158		Domain of unknown function (DUF4158)	Coggill P	pcc	Jackhmmer:A8LT43	Domain	The exact function of this domain is not clear, but it frequently occurs as an N-terminal region of transposase 3 or IS3 family of insertion elements.	25.00	25.00	25.20	25.00	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.63	0.71	-4.76	108	1440	2011-01-18 15:32:58	2011-01-18 15:32:58	1	7	737	0	250	1165	105	151.80	26	19.69	CHANGED	lLosppcppl..hslPs..s..cpclh+aaoLscpDlplIp..p.+RtspNRLGaAlQLshlRa.Ghhls....s....spplPtsllpalApQLtls...s..s.s..hppYu.p.RcpTRt-HhtcltphhGa+sFst..st..h.p.pLhpaLhphAhpsscshh.LhcthlshL+pp+llLPuhoslERllucuh	..............................Lo.tpptth..hthst..sct-L.hpaaohs-t.Dlph.Ip...p..+R.tstsRLGhAlQLshhRh.Ghhls....s....hpthsssllpal.u..p..QL.tls....s...t..p....htp.Ys..p..RppT+tcHhtplpphhsac.ast.........st..hp.plh.p.hLh.p.hAht.sscs.h..LhsthlthLhpp+lllP.uhsslpRhhups.............................	0	50	136	189
+13543	PF13701	DDE_Tnp_1_4		Transposase DDE domain group 1	Coggill P	pcc	A8LT71:jackhmmer	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	25.00	25.00	25.10	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.28	0.70	-6.31	10	2054	2012-10-03 01:22:09	2011-01-18 17:04:24	1	6	411	0	238	1429	381	279.80	36	91.76	CHANGED	FsslsG+pVhucF-GGslSSDuGllLl+plDcpltlspRhAsClcDtR+sSYlcHSlc-LluQRIYQIAsGYEDsNDuNpLR+DPhFKlALs+lPhsssst..LASpPThSRLENslspp-lp+huR.............uFVDtFL-SYt+sPc.IVLDMDsoDDtsHGpQEhAFFNuYYpssCYhPLalFEupoG+LLsApLRPGcpcoGctslshLpRllcpIRctWP-T+IllRGDuuFupPElMshCEspsssD.lFGhuGNssLhc+tsslls-sRcpctpptcpshh...ts..t................RhacpsaYsA+SWscsRRVVhKsEhtucGsNhRFllTsL......scssPpcLYcchYCsR.GpsENRIKEhKhDLtSDRTSscsFluNQLRLFlusAAYVLhpulRppsLspT..LAKApsuTIRLpLlKLAARVslotRRIllcLPouCPhpsplthshppLphtp.hs	..........................................................................................................................................................h..................................................................................................................................................................................................................................h.....lDhDso.........u.ppp..................a...h....t....sa..Ph..h..hh.................tt............hR.up......s..tt..t..h.....t..ht.h...h...t....h..........................................hRh...D.ut.....t.h.......h..............................................................................................................................................................................................................................................................................................T.sh..................t....s.s.pp.....h.....p.....h......YptR..G.p.hEN.h.IKEh...p.s.hh.....s-.......+h.s.......op..............shhtN.plRhhhsshAYsLhh...hh..p..h...h..................s.......t........p........h....t.......t.h....p....htp...hR...h...hhl+lss+hs.ps.Rp.hlphsph.h...shtt.h..h..........th.....................................................................................................................................................................................................	0	49	161	214
+13544	PF13702	Lysozyme_like		Lysozyme-like	Coggill P	pcc	Jackhmmer:B0G1S2	Domain	\N	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.01	0.71	-4.75	63	1147	2012-10-03 00:09:25	2011-01-18 18:31:40	1	9	690	0	68	686	23	158.50	43	52.92	CHANGED	lspcVlpacshVcchApchu..ls-.YlsllLAlhhpESGG...cssDlMQSSEShshs.............sNsIpDs-tSIcpGVphaspslcpApppus....-.lcsslQuYNaGsG.alsaltppG.spYoh-LAppFScphs..........upphth....sh..tt.hh..sYGshhYsppVh.pYh	....................................................tpVhsapPhVcchscE.....hslsp..hssllLAlIhsEStG...........ps.tD..V........M..Q....SSEShuhs..................................sNoIps.scpS..I+QGlphhuphLtpApc.tul.....Dl.oslQuYNaG.su.Yls..alAppG....pcaThpLAcpaS+-hs............sGpphsY.pPlul...hsGGahY.NhGNhaYsphVp.............................................................	0	16	35	47
+13545	PF13703	PepSY_TM_2		PepSY-associated TM helix	Coggill P	pcc	Jackhmmer:D2BX46	Domain	This family represents a conserved TM helix found in bacteria and archaea.	30.00	30.00	30.20	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.24	0.72	-3.81	95	2542	2012-10-01 23:59:14	2011-01-18 18:43:04	1	35	1345	0	728	2488	143	87.60	25	18.15	CHANGED	ahhplHhsLh.lsth.....hGthllulsuhhhllslloGllla..............+hh+pha...shR.tc..stcp.hhD.hHshhGlhslPFhlhlshTGlhhhht	....................................hhpLHtsLh..lsts.............Gphllslsuhhh.l.lhll.o.Glhla...h............................p.h...h...p.t.h.h...........thc....h......pp.....st.+p...hh-..hHshhGlhshhhllhhshTGlhh...s..............	0	155	412	583
+13546	PF13704	Glyco_tranf_2_4		Glycosyl transferase family 2	Coggill P	pcc	Jackhmmer:A8LQ72	Family	Members of this family of prokaryotic proteins include putative glucosyltransferases,	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.51	0.72	-3.67	164	934	2012-10-03 05:28:31	2011-01-18 18:44:27	1	33	490	0	305	3098	709	103.40	19	24.61	CHANGED	+NEshh...L.palt...a.a.p.p.l.G....h..s.c..hll..h...sN.sssDso....sphL....tp........h....sc....ls......lhp...ss..................t.sa................pp..tt.ht....h......s..........hhsh......h..hp...p..h......s.........p..s.....cW..hlhlDsDEFlshsstt...tslpsLh	............................hNpt...h.l.ta.lt.......a..a...p..t..l...s.....h....c...c.....hhl..h....ss..s...s...s.D.s..o.......scl.L....cp.......h......ss.....lp.........lhp...p..p...........................................p..th......................tt...tp..ht......h......c............hhpt.......h..hp......p...h.....t..........................t..s.....-W..llhlDsDEhlhsst.....tl....h............................................	0	101	194	240
+13547	PF13705	TRC8_N		TRC8 N-terminal domain	Bateman A	agb	Jackhmmer:Q8WU17	Domain	This region is found at the N-terminus of the TRC8 protein Swiss:Q8WU17. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain [1]. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG [2].	27.00	27.00	27.40	27.30	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	508	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.74	0.70	-5.93	13	190	2011-01-19 10:54:33	2011-01-19 10:54:33	1	7	80	0	116	183	0	433.60	38	72.60	CHANGED	lhull-VsLRVPulhllDhlhphsh.tuhs.........pp.........................................................................................hphphlthslphlGhls...........usslLhLsp++LlplYhahhuhlLhhsuahlsh.h..l..c.....-thlhls.hph.c.suhh............huhllhtl....lhssca..hhhhhshhhh.Pllhplh.lPh.s............Lhhlsshshhhoshtshhhlhpth.hshphsh.hh.....hthhplaGltuLlpshWp+LpVPslLpVFWlschshQhhs.....hhspp-ssh.....s.pphhhllhshlsssCsoshslLGhosllShlA+hluphhphaLtuh-s.cccp...hGhspuVhhhILALQTGLouLpsccRhlhLuhsLhlllTAlLp.lHpIs-PlLhuLuAS+spShpRHhRsLslChFLllhPlhlsahLhpaashshWLLhVsu.slplsl+VlsoLhhYsLFMlDuaRpp.WEKLDDhlYYV+usupslEFlhulhlhu.GAaphlFtu.....hohIpAshhhlHuYFNIWhcApsGW	....................................h..uhlpVsLRVPslhllDhlap.....h..u......................................................................................................h.hhhlth.hp.h.hGhhl...........SsllLh..Lsp..pp.......L.hphYhah.hshLLhhsuh.lsh........h..............................shal-.hu.h.phsshh................hu.lllph..............hhtht....l.lhShahh..llhclh......lPl.s...............llhhsphshhhssh.llhhhhp.hhh...shphsh.hh.....hphhcl..YGL.sLh.shWpplhhPslhhV..FWLshhshQh.hs........hhsspspsh..........shpphh.lhhs.........lhpsCsosholLGhshslS.lAhhlhhhhhhaltuhct..sc..............................hGhstuVhhhILAlQTGL.tLps.cRhhhLSh.hhlllsulLp.hhphsDPllhuLuAS+sp.Sh.h+HhRsl.lshhLhlhPshhuYhlhpaathshWLhhlhu.sl.ssLpVlsoLhlYsLFMl-tap.p...hEphDDhlYYVpuThpllEFlhulslhu.Gs.phlFtp.....hohhtuhhhhlHuYaNl...aLpAp.GW...............	0	31	40	78
+13548	PF13706	PepSY_TM_3		PepSY-associated TM helix	Coggill P	pcc	Jackhmmer:D2BX46	Domain	This family represents a conserved TM helix found in bacteria and archaea.	29.10	29.10	29.10	29.10	29.00	29.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.77	0.72	-4.54	99	885	2012-10-01 23:59:14	2011-01-19 14:09:45	1	19	462	0	319	1056	191	36.90	30	8.04	CHANGED	pphhhhlHpWhGlhhuhllhlhFhoGslhha.....ps..p..lsp	......p.hhhlHpWhGLlhuhlLhlhhloGslhha.....cp-ls..........	0	65	174	255
+13549	PF13707	RloB		RloB-like protein	Bateman A	agb	Jackhmmer:C7PC62	Domain	This family includes the RloB protein that is found within a bacterial restriction modification operon.  This family includes the AbiLii protein that is found as part of a plasmid encoded phage abortive infection mechanism [1]. Deletion within abiLii abolished the phage resistance. The family includes some proteins annotated as CRISPR Csm2 proteins.	27.00	27.00	27.00	27.80	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.54	0.71	-4.63	120	422	2011-01-19 14:48:00	2011-01-19 14:48:00	1	2	358	0	96	390	16	178.60	20	87.08	CHANGED	hlIlsEG.p...TE.pYFctl..................t.hthpphplplhstt...............................ssstpllcpstchtp........................................................................tpphDplasVhDt.D.........t.ptpphp.cshpt........scpp............thplhhSNs.sFElWlLLHapths............thsppthtt...ph..pth.........ssYpKsp.................hthhhpphts...AlppAcpltppt.tppt....................ss.sTslh..pLlctlt	...................................hhIhsEG..p...TE..tYFptl..................p.hhhsp..hpl..phhstt........................................psstpllctshphhp....................................................................................................tph.cpl..ahVhDt.D..................ptpphp...p...shph...........scpp....................phphhhSN...sFEhWhLLHFpthst.............................t..ppphhtph.....hpthh.....................tpYpKsp...............thhp.hhpphtp..........AlppApphhtp...pp.t.....................ss.hopl....pllc.l.h............................................................	0	48	80	92
+13550	PF13708	Methyltransf_27		Methyltransferase domain	Coggill P	pcc	Jackhmmer:Q3IV21	Domain	This family contains methyltransferase domains.	25.00	25.00	25.10	25.60	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-10.97	0.71	-4.77	34	854	2012-10-10 17:06:42	2011-01-19 15:25:22	1	11	411	0	44	544	11	171.00	53	64.67	CHANGED	thp+slDpphWccLhpcoGhhshMsupt+cpWpcplp..ts...........shPshotcNIhuTFppLhts+pchFp+GllslF+pL..........ShcaKTN..pshtFG+KlIl..ssllp.....hp.ph...uhs.......hshu...pps.pLsDLt+hhtllcG...KPhs-..pRpshs.tthtpthptss..t.............................................t.pshEsphFpl+hFpp.GosHlpF..p+s-Ll-+lNpllAcaYP.ssL	........................................................................s.ITRslDRcIW+cLMpcoG.MholMsupsRDpWh+sLE...D....................shPEISEsNILSTFcQLHpNKs-VFERGVINVF+uL...............................SWs.....YK...TN......sPC......+F...G.....p.KI.....Il..NNLVc......Ws.+W.....Ghp.......L.sG....ptD.pLsDLERMLaLh....sG...KPlPD...NRpsIs...lc.Ls-alpssp....s..........................................................p..ppaEDEh...FpIRYFpK.GouHITF..++.-..Ll-+lNDIIA+aaPshL...................	0	7	15	25
+13551	PF13709	DUF4159		Domain of unknown function (DUF4159)	Coggill P	pcc	Jackhmmer:C6VZA7	Family	Members of this family are hypothetical proteins. TM prediction shows them to have two transmembrane regions, with a cytosolic region of about 25 amino acids between the two, and an N-terminus outside the membrane.	25.00	25.00	26.80	26.30	24.00	22.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.58	0.70	-5.21	124	420	2011-01-19 15:53:05	2011-01-19 15:53:05	1	9	358	0	171	402	276	209.10	30	33.09	CHANGED	hplAhl...ho...............G-hpsD...........suLpsLsphl...........sppTslcss..t..hsVclss.s-Lh..haPhlYhsspssh.h........ospt..hspLcpYlpsGGhlhhDsp............t.tsshstsh........pc.hphlhs...ssLp.lPs-Hslh+sF...Yhl..........hsutshhh-ttst...................h.hthhsDG....hhsllhsss.DhusuWshspps.pshhshsss..............................AhRhGlNllhYsL	...............................................plAhl..hs..................GchssD..........psuLpsLsphL...........tp+Tulcsu....p...hsV-hsp...D-Lt...haPhlYhshssss..h..........SspthsplcsYh.pp.GGhllhDsp........c.......t.tushstsh..............pchhphlhs....hssLcslPs-HsLh+sF...alh........-.hP....uphputshWsEstst........................sh.hth.sDG....hssllloss.Dhus.AWuhctpssshhsssss.....p+.........................hAhRhGVNIVhYsL..........................................................................................................................	0	72	126	147
+13552	PF13710	ACT_5		ACT domain	Coggill P	pcc	Jackhmmer:D2BYU0	Domain	ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.88	0.72	-4.16	79	4946	2012-10-02 00:29:19	2011-01-19 17:24:13	1	10	3420	7	1010	2625	1922	62.70	40	43.40	CHANGED	ppstsLpRllpllR+RGFplsshshpt...tssst....hplplsVpu.pRslch...LspQLsKLhDVhpl	.........NcsGsLsRVsGLFu+RGaNI-S.lsVus..oc-ssl.................SRls..l..s..s..s..u.p.-.p.s.l.EQ......lh+QLpKLlDVl+V.................	0	289	629	835
+13553	PF13711	DUF4160		Domain of unknown function (DUF4160)	Coggill P	pcc	Jackhmmer:C6W4D5	Family	\N	23.00	23.00	23.60	24.30	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.29	0.72	-4.12	168	574	2011-01-19 17:56:36	2011-01-19 17:56:36	1	4	384	0	179	516	65	63.30	28	72.08	CHANGED	Glhlhhah...ppHpPPHlHsphuc....tpAhhslps......hph.hpG..phsp+.pl+hlhpalphapccLh..ppWp	...................Ghhlhhah...p.p.H.pPPHlHsp.hus......hcuhhtlps.........hph...hcG...h..ss+..ph+hlhtaht...+pcpLh..ttWp..............	0	63	119	156
+13554	PF13712	Glyco_tranf_2_5		Glycosyltransferase like family	Coggill P	pcc	Jackhmmer:C6VYA4	Family	Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.48	0.70	-5.10	121	312	2012-10-03 05:28:31	2011-01-20 09:28:06	1	21	211	4	52	1116	294	202.30	38	68.24	CHANGED	ILhVsClNs-cl...acQ.Cp+.pIcsL..hVPP..GYlVQlhPIRsA.cSMsSAYNcAlSaPAKYK....VYIHQDsallN...cshhhsLlsLFp-s..E+LGlIGluGAQalPsNGlWWE..GKslV..GK.VIpYpp..psYphhp.hpphh.Y....t.spsFhsVpAIDGLlMATQYDIP........WREDLFpGFHFYDVSQSLEFp+.A.GY...hs...sQ...t...s...h...W...CIHYsu.Dp.h-.s.shhc.ph+p.FVE.+Y	...................................................................h.hlhs.pppth...htp..h.....l.ph....hs.s..sh.....hlph.hs.lR.s.........A..pSMsSuY.Np...Alsp..A...+aK......VYlHQDsallN......pshh...hsLlplF.p.c.p.....-cL.G.....h..I............G..........h.....s.....Gu.p..h...l.P...s..s.....G....l.....Wh.-........up.s...hs........GK.........Vlt..Y....t.p.....h..........a...h..t.....p..phh............tsp...sahsV.psI..D...G.LlMA.TQ.YDls................W.REDLF...pG..F.H.....F.Y..D..VSQShEFp+.A.GY...pl......sp....t.s....h..W.C.I.H......a......st.....-t.......t......s...s........a..c..ht+h.FlccY........................................	0	10	37	46
+13555	PF13713	BRX_N		Transcription factor BRX N-terminal domain	Coggill P	pcc	Jackhmmer:Q17TI5	Domain	The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2].  BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway.  BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot [3]. This family features a short region, also alpha-helical, N-terminal to the repeated alpha-helices of family BRX, Pfam:PF08381 [1]. BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action [4].	24.50	24.50	24.50	26.70	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.72	0.72	-4.50	53	188	2011-01-20 14:44:40	2011-01-20 14:44:40	1	21	25	0	128	193	0	38.00	41	4.56	CHANGED	s-Euu.+scuAK.-sIKSLTuQLK-MAc+l...s.uuhc....pscsss	.........-EuuKs+AAK.ElIKSLTuQLK-MAc+l...s.Guhc...p.t...t..........	0	16	77	103
+13556	PF13714	PEP_mutase		Phosphoenolpyruvate phosphomutase	Bateman A	agb	Jackhmmer:A1B6C5	Domain	This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein Swiss:O86937 has been characterised as catalysing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr) [1]. This enzyme has a TIM barrel fold.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.66	0.70	-5.15	124	2953	2012-10-10 15:06:27	2011-01-20 17:46:56	1	17	1973	94	941	4275	3390	240.70	35	79.80	CHANGED	F+p.LH...pts.p....sl........................................lLsNsWDusSAclltps........G...........apA.luToShulAtuh.GhsDu.........ptlshsph...l.stlppIsps.s.s................lPl..osDhEsGY.....upp....spplscs...lcclhpsGssGlslEDp.........t.......tttlh.sh...........pptst+lpAs+puststs...hhlsARsDsalht............tsstls.......-slcRupAYtc.AGADslFlsGh.....pc..sp.l.tplspth.s.......hP..lNlhs.h..st.t....hshscLtplG.VpRlShGsthhcsA....hssh.tpsspplh	....................................................................................................hRt.Lt...pp....p....sl.lsusasuh..sAhlspps.........G.....................apA..la.h.SG.uu.l.A.....A.....S.....h......G.....l......P..Dl.........G.lsohs-l...l.ps...s..ccI..scs..s...s................................lP.l..lV.Dh.....D..sG.a...Gs...........s.h.N.luRT...V+p.h.h.c.A....G.sA.u.lpIEDQh......................K+CG.....+...ssKtll..st..........................-..E.hl.s.+I.+AAh-A+.......scss............alIhARTDAhh.................................scGl-s..AIcR.Ap...AY.......s....-.AGAD.hlF.s-uh............psh..pp..h...cphscsl.p..........sP...lh..ssh..p.....ut.o...............hosc-LtphG.lshllashus.hRAh.pAhppshpt..h......................................................................................................................................	0	228	531	766
+13557	PF13715	DUF4480	Cna_B_2;	Domain of unknown function (DUF4480)	Coggill P, Eberhardt R	pcc	Jackhmmer:A6L3W4	Repeat	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF07715 and Pfam:PF00593. There is a single completely conserved residue G that may be functionally important.	32.20	32.20	32.20	32.20	32.10	32.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.88	0.72	-3.93	100	11370	2012-10-02 19:08:27	2011-01-21 13:39:15	1	110	309	0	3174	13036	3876	84.30	31	8.98	CHANGED	plpGtVh...sp...p.s...ps...ls....usslhhp...ss.p......ps......sh.Tst......sGpFplp....sp.....t.ss...pLhh..sh..hGaps...hp.h.lp....tp.t...p........l.s.lh...L.pp.ssp...p..Lc.E..Vll	..............................lpGpVh....Dp....p...s.......p.P...l.....GAo..Vhlc......Go.s..................pG........sl...T..Dh...................cG..pFslp....ls.......s...s.s......t..Lh..h...Sa..l..G..Yps.....pp...l.p...l.s.......t...........s.....................l..s.lt...L...pp...c.s.p.....t...Lc.E.VVV..............................................	0	1390	2842	3163
+13558	PF13716	CRAL_TRIO_2		Divergent CRAL/TRIO domain	Bateman A	agb	Jackhmmer:P32525	Domain	This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-11.05	0.71	-4.30	101	1520	2012-10-02 01:12:42	2011-01-21 18:21:51	1	65	240	9	821	2870	21	140.20	22	13.59	CHANGED	hth.h.tup.sppGpsllhhs.uphh..............................................shcpllhYlhpph.pp.....sps..asllh.pssh.................................sp.shshlpph..............................................hphlstt..........................htpp.lptlal.l+ss.....hhh+phht.............................shhphh.stth.ttc...............................................................lhh.................lsslspL.....hphlc....hspL..pls...........tshpa-pp	.........................................................................................................hh......tG..sp..u.ps.lls.as..sp.h......................sttp...............shcpl..h..h.....Yl..h...p....h...h.c.................h.s.tps.........ahll.h..pp.th.................................s..p........h...s....h...l+ph.....................................................................................h..p.hlspp...............................hhpN..L+........s.lhl..l+Ps...............hah+ph..h...............................hhhp.hh...ss..ch..thK.....................................................................................l.h..h.................................l...s.....o...l...p...c..L.....tphls.....hpQl..cls......tshpast.......................................................................................................................................................................................................................................................	0	213	322	549
+13559	PF13717	zinc_ribbon_4		zinc-ribbon domain	Coggill P	pcc	Jackhmmer:Q5HCD9	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, Pfam:PF12773.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.89	0.72	-4.26	74	110	2012-10-03 10:42:43	2011-01-24 12:58:18	1	21	79	0	72	614	889	35.80	31	8.64	CHANGED	MplpCspCpspapls-pp.ls.spGt.pl+CspCpphah	......MplpCspCpspapls-cp.ls.sput..plcCspCtpha.....	0	40	57	69
+13560	PF13718	GNAT_acetyltr_2		GNAT acetyltransferase 2	Coggill P, Eberhardt R	re3	Jackhmmer:P76526	Family	This domain has N-acetyltransferase activity [1,2]. It has a GCN5-related N-acetyltransferase (GNAT) fold [2].	24.60	24.60	24.60	26.20	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.27	0.71	-4.99	88	1293	2012-10-02 22:59:21	2011-01-24 13:23:31	1	20	1187	2	418	1028	31	180.60	42	24.00	CHANGED	chhuLhVuuHY+sSPNDLphlhDAPupplalLh..........................................s.ss............cllssl.lshEGpls.pc...hs.ppshpttpRspGcLlPhslupphtcppFupLsGhRlVRIAscPshpp.........hGhGochlph..lppa..hp..............................................................p..plDalGsSFGhTspLh+FWp+.sGFtsValppstsphoGE+oslhl+s.....Ls	...............................latLLsuAHY+TSP.DLpthhDAPup+hhhht..........................................sts.................clhGsl.......hl.s.cEG.s...LS....pp...ls.pslh.u.G....hR.............RP+GsLlspoLutphsss.tAA.sLpGtRlsRIAVHPshQc.........pGhGpplltthhphh..........................................................................................................................................................................p..plDYLuVSFGh..Ts-Lh+FWp+.sGFl.V+husp+.-suSGpYoshhLhPl.s...........................	0	131	221	337
+13561	PF13719	zinc_ribbon_5		zinc-ribbon domain	Coggill P	pcc	Jackhmmer:Q5FCF8	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, Pfam:PF12773.	27.60	27.60	27.60	27.70	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.94	0.72	-4.37	79	534	2012-10-03 10:42:43	2011-01-24 14:21:25	1	21	487	0	215	626	893	36.50	35	10.00	CHANGED	MplpCspCpspapls-pp.ls.sput.pl+CspCppsahh	........hpCPpCpTpaclsssp.ls.hpst..tVRCupCpplFp......	0	55	128	174
+13562	PF13720	Acetyltransf_11		Udp N-acetylglucosamine O-acyltransferase; Domain 2	Coggill P	pcc	Jackhmmer:C5B7S0	Domain	This is domain 2, or the C-terminal domain, of Udp N-acetylglucosamine O-acyltransferase.  This enzyme is a zinc-dependent enzyme that catalyses the deacetylation of UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine to form UDP-3-O-(R-hydroxymyristoyl)glucosamine and acetate.	24.50	24.50	24.70	24.60	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.68	0.72	-3.76	349	2605	2011-01-24 16:19:52	2011-01-24 16:19:52	1	15	2381	24	620	1760	1696	83.10	37	31.62	CHANGED	DVPPashssG.s..Ap..htGlNhlGL.+R+GFop..-..plp.tl+pAY+lla+.sG.h.....slp-Al.ppl.pp....hsp.......sscl.ppll...cFl...t..sop.......RGlh+	...DVPPYslAp....G....N...cA..p...hGlNl.GL.+..R.RG...Foc......-....plpsl+pAY+hlY+....sG..h......slc-.sh..t...cl.tc....spp...........pspV..pthh....-Fl.....p.....pSp.....RGllR....................................................	0	196	396	518
+13563	PF13721	SecD-TM1		SecD export protein N-terminal TM region	Coggill P	pcc	Jackhmmer:D2BRP0	Family	This domain appears to be the fist transmembrane region of the SecD export protein. SecD is directly involved in protein secretion and important for the release of proteins that have been translocated across the cytoplasmic membrane.	25.00	25.00	25.00	27.50	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.13	0.72	-3.75	100	2015	2011-01-24 16:50:55	2011-01-24 16:50:55	1	5	1305	0	300	1070	399	98.20	35	20.67	CHANGED	lN+YPLWKYLl..llhllhlGhlYALPNLYGEDPAVQIou.p.p.u.s..p..s..s..s..t..s...pV.pssLcpssIsh..c..ult.l.-s....s..s..lLl.Rhsss-sQLpA+-h....lppsL.....G.c.....sYlVAL	....................W..h..h..l.l.h.sl.llulLYA..l.PNl..aG--PAlQIousp.p.G.s..s...h..s..-..t...s......pVpctLpppsIsh..K....Sls..h..cs...........s..slLl.RF..c..so..DpQ.lpA+-sLppsL.....s.c.....pYlVAL...........	0	49	131	219
+13564	PF13722	DUF4161		C-terminal domain on CstA (DUF4161)	Coggill P	pcc	Jackhmmer:C5BCA0	Domain	This domain is found at the C=terminal of most known CstA domain-containing proteins. The function is not known.	23.00	23.00	23.20	23.20	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.76	0.71	-3.83	141	3040	2011-01-24 17:03:47	2011-01-24 17:03:47	1	5	2329	0	528	2010	121	127.00	41	20.10	CHANGED	Ghs...huhhapFAlhatAlFlLTolDuuTRluRahlQ-hhu.......h......htppphh.ssthluoslslshhGhllhtG.............shsslWPLFGhuNQlLAulALhlsosh.Lh+ht+t..p.....asa.lshlPhsahhlsThsA	...............hh....huFWYHFAILFEALFILTulDAGTRuuRFMlQDlLG........sh.............ht..c.s.csl....suslluTshsVs.hWGalLapGshD...........PhGGlsoLWPLFGluNQhLAulALhlsoVlLhKhp+p....p................ahW..VsllP.ssalllsThsA.....................	0	173	322	436
+13565	PF13723	Ketoacyl-synt_2		Beta-ketoacyl synthase, N-terminal domain	Coggill P	pcc	Jackhmmer:D2C0A5	Domain	\N	25.00	25.00	25.90	25.10	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.44	0.70	-5.08	53	581	2012-10-02 12:25:54	2011-01-25 13:01:22	1	2	555	0	160	516	37	202.70	26	79.93	CHANGED	Wp.p.Wup.ss.tth..ss......s.sstPtlstlPsMpRRRhSpho+lulcsuhplh......pt..pss..hlVFuSRHGElpRohsLLpslhsppslSPTuFuhSVHNsuuGhaoIhsppshssTSlAAGp-ohppullEAhuhLp.p.u.sppVLlVshDpPlPphYpsa.s........ppts.hsaAluLlLssGss.hphs..................hpss..ssss..pps.......shs.puL..phlctllssp.....s.ph.shsu.ppppWpWp	................................................................................hsth.s.lP.sh.p.pRRhop.hs+l.ul.p.s.u...h.t.hh.........................pp........t..p.s........s.......llas.Sp.aG-lp+shpllp.s..L..h..s..p..p.....s..l..S..PTsFu.SVHNussG.hoIhtpshsssouluA.upsoappuLhEAhshLpp..u...tppV.Lll.shDp....h......Pph..Yt.............p.s..hsaAlulll.p.s.usp....hp.hp.......................................ht.t.........tt.................tsh....hht.........................h.h.................................................................................................	0	34	79	119
+13566	PF13724	DNA_binding_2		DNA-binding domain	Coggill P, Eberhardt R	re3	Pfam-B_65234 (release 24.0)	Domain	This domain, often found on ovate proteins, binds to single-stranded and double-stranded DNA. Binding to DNA is not sequence-specific [1].	25.00	25.00	25.70	44.70	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.76	0.72	-3.82	15	45	2011-01-25 13:21:28	2011-01-25 13:21:28	1	1	14	0	35	46	0	56.70	41	16.04	CHANGED	MG.paRFRLSDMMPNuWFYKL+DMpKsRs+sstssstt...................ssouphppsSss	...MG..pa+FRLSDMhPNAWFYKL+DMp......+sRtpsssss.pt...................ssosppppsS......................................................................	0	4	19	27
+13567	PF13725	tRNA_bind_2		Possible tRNA binding domain	Coggill P, Eberhardt R	re3	Jackhmmer:P76526	Family	This domain, found at the C-terminus of tRNA(Met) cytidine acetyltransferase, may be involved in tRNA-binding [1].	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.23	0.72	-3.91	114	1005	2011-01-25 13:25:22	2011-01-25 13:25:22	1	12	956	2	333	715	7	106.60	31	13.55	CHANGED	Fc+Rh.....h.tLhu.hphpp..hs..........................h...ts..............................phsthlo.......................................shDh+RL....csYu.pshh.sacsl...lsh...lscLhhtthht..............hplssh....ppslLluhsLQp+sh-plsp-LsLsup...pt..l	................................................RRch..tLhp.as.hcs.ls.................................hts.....................................h.-ssLo.......................................................spDhp..c..L...suaA.hutt.shhss.....lss...LhRLl.ps.............................tl..........thshLhu+l.pptS.uplsppLp.LsGc..+..h...........................	1	106	180	269
+13568	PF13726	Na_H_antiport_2		Na+-H+ antiporter family	Coggill P	pcc	Jackhmmer:C5B988	Family	This family includes integral membrane proteins, some of which are NA+-H+ antiporters [1].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.95	0.72	-4.07	42	1096	2012-10-02 15:12:49	2011-01-25 13:28:17	1	4	1056	0	144	1175	19	88.20	47	20.18	CHANGED	NAVllAVhlMLlLSLhR..lpVVlALhluAlVGGLlGGLulspT............lssFs.sGLGGGAplALSYAlLGAFAlAIo+SGLsclL.....Aptllphlu	........NsVlluVl.lMl.lLs.L..hR..lNVV.luLhluALVGGLlu....G.h....u....lsco........................lssFt.s.........GlssG.A.p.l.ALSYAlLGu.F.A.s.AI.S+SGlschLsppllphl.p............................	0	34	76	118
+13569	PF13727	CoA_binding_3		CoA-binding domain	Coggill P	pcc	Jackhmmer:C5BFR0	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.93	0.71	-4.44	56	4439	2012-10-10 17:06:42	2011-01-25 14:11:05	1	19	2789	2	1096	3621	674	172.50	16	32.80	CHANGED	thhslYps.hph+shhpths.clhtuWh.ls..h.h.h.h.hs..lha..t..h..p......s..h...hSR..lalshW.h.hsuh...sh.llhtRhll...tthl...pp.ht+....p...s....thp....htsl....ssss....uppht...ptl....p..pp.ts.u.h..h....h.l.GlaDDc.......s.ssp..s..h.s........uh..PhlGslspllchsRpsclcplalALPlssEpcIhcllpchtspsVsIRlhP	....................................................................................................h....hYp......h...h.th.h.p.p..hh..p....lh.t.shh..hs...h..l..h..h......hh....lsh........h.....h.....p............p.h.......hs..R.......hh..h..h...h.a........h....lhsh......hh...lh...h..hRh...hh.......+h.h.h.....................pp....hhp....................p............p................pts............hh..ls........usss....u...p...t.l..h....pt.l...........p...p.p.s.p....h...s...h..c......ll..uh....h..D-c...................t..s.tt..sp.....h...t...........................sh...s..l...h.G...s...h..p....p.l...............p....h..s.c.p........t..........p.....l...c.p........lhl...A....l.P.....s..t..t.ph.pc.llp.h.pp..h.s.sp.hhhhP...................................................................	0	367	716	919
+13570	PF13728	TraF		F plasmid transfer operon protein	Coggill P	pcc	Jackhmmer:Q9WTC0	Family	TraF protein undergoes proteolytic processing associated with export. The 19 amino acids at the amino terminus of the polypeptides appear to constitute a typical membrane leader peptide - not included in this family, while the remainder of the molecule is predicted to be primarily hydrophilic in character [1]. F plasmid TraF and TraH are required for F pilus assembly and F plasmid transfer, and they are both localised to the outer membrane in the presence of the complete F transfer region, especially TraV, the putative anchor [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.16	0.70	-4.85	53	761	2012-10-03 14:45:55	2011-01-25 16:40:05	1	4	447	0	91	751	65	167.80	27	71.99	CHANGED	GWhWYs-s....p.pc.t........p..tsss...........ss....s....t.ts.................s....t............pph..ph..h+pthpchhspAlhpPo...ENltpahplQchhhc+uspFupsappslhppPpLDYslc.pP...h..sssutpshhp.tcp.pppp.pslppLu.ppaGLhaFYcu.s..ss.hspthusllpsFucpa.GhsllsVShDGshhs..thPpsch...DsGptp.plsl...p..hhPALhLVsPpo........tphtPluaGhhSp--LhcRlh	..............................................................................................................................................................................................................................................................tt.tpp.hltphs..pca..u..lh..F..Fh..pu.p..Cs.hCc......phsPll....pphu...p.p...Y....G...h.....s.Vhsl...o...l..D..G..tsss...............thP.phhs..............spu......hp....p.h..s.l.........h..hhPshhLlssps..........hph..hPls.Ghhs.spl.tp....................................................	0	24	44	71
+13571	PF13729	TraF_2		F plasmid transfer operon, TraF, protein	Coggill P	pcc	Jackhmmer:D2BTB8	Domain	\N	25.00	25.00	26.00	25.00	23.30	24.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.40	0.70	-5.59	29	545	2012-10-03 17:14:37	2011-01-25 17:05:16	1	3	385	0	74	341	4	257.80	36	66.69	CHANGED	AshhNPALluttp.p.Dc....hu.lllP..ulGspls..D.DplhDc.hDslpDshDthpsshss.p................tssscLsssLpsLcsspAhussGsuhu.....lulPsphlshuhhsKuYssuhstusl.spsDlshLpsht..................sss.ssLsSputshuusls-lGlAlA+ph.s..hss.hslolGlTPKhQ+lpsYNYssolpsaD..ssD.acs......scapsscouFNlDhGhshphscsaplGlsupNLlupc..l-Tpphp.............................uhp.TYplcPhhTs.GsAaps..chhTlusDlD	................................................................................................................ushhNPA...L.lAhhc.p..Ds......hu.llLP..ulG..hphs.....D..csl.sp.lD.clpD.....p.h-..acpss.s.t..............................tssspLscpLpt....hpspp.hpupsGsulA......sulP.spsl......uh......sh.......hsKuYupshVsupl...sss.shphlcph.................................s..ppthsS.sss....upus.hlo-hGlulAKph.s........huu.pplSlGl.............T.............PKlQ.+lhhY......sYss..o..l....p..sYD....tsD..acs.............sch..s-suFNhDhGss..h...ls....-..paplGlsupNLluR-..I-TKslt.............................shppTYpl+PpsTs..Gsuaps..DhhTsusDhD................................................	0	11	30	58
+13572	PF13730	HTH_36		Helix-turn-helix domain	Coggill P	pcc	Jackhmmer:C2JR21	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.65	0.72	-3.84	198	1833	2012-10-04 14:01:12	2011-01-25 17:46:11	1	15	1152	0	237	1777	177	53.80	25	20.10	CHANGED	pp.Lshp..sphlhhhlhshs..........ttt..sas..o..............pppl.......uphh.......shu.cp.....olpctlppLpctGa.....l	...........................................p.t.tthlhht.Lsshu...............sppsh..saP....o..............hppl.....Acph...........thu.cp..........TlppslppLcctGhl.........	0	81	149	191
+13573	PF13731	WxL		WxL domain surface cell wall-binding	Coggill P	pcc	Jackhmmer:C2JPG8	Family	The WxL motif appears in two or three copies in these bacterial proteins [1] and confers a cell surface localisation function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan [2].	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.73	0.70	-4.52	83	1929	2011-01-26 11:14:11	2011-01-26 11:14:11	1	25	266	0	120	1070	0	205.50	24	49.88	CHANGED	ssAtss....so......sso.sspVpFpss..............sVsPsss.s..s.....s...ss.lsP...DP.....sts........uo..sus......Lslsas.s.s.hsFGppp.Ios...ss...pshhup.........................p.h...t...t.st............ptss......hlpVsDhRG..Tpp.....GWpLospts.p...h..psus.....tp.........pLsGu.p..................lshsssphts.ss.ss...ss...................sPsshss.s......hsls......Gs..........susslhsAssupGt.GsWhhpass...........................p......slsLslPupshK......AssYTuslTWsLssuP	............................................................h...............hto....l.h..s................P.ss.s.............shps...s.......sts..........ss..sGsLslsh.s..s.s...hsFGp.p....Ios...ps...psahsp.....................................................s....p.h....t.sss..............ptss...alplsD.....t.R.G..Tps................GWp.Losp.s..p...Fpsss...........tp.........pLs...Gu..p..................lpht..ss..ss..ss..s...sp...ss..........................sPss.pt....s.........hsls....s..ss......................ss.sslh..s...A......s......p......s.........pGt....Goa..h.hphsp.....................................p......slpL.p...V...Pusssp......utpYpsslTWsLsssP.............................................................	0	60	97	102
+13574	PF13732	DUF4162		Domain of unknown function (DUF4162)	Coggill P	pcc	Jackhmmer:C2JJQ9	Family	This domain is found at the C-terminus of bacterial ABC transporter proteins. The function is not known.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.69	0.72	-3.47	129	1360	2011-01-26 13:50:07	2011-01-26 13:50:07	1	3	1176	0	282	884	167	84.40	27	28.07	CHANGED	Gslp-lKcpaGc...pp..lhlc....sc...tshp.t.....Lppl.......sGltph......p.p....p.p...ss...h..p..lp.lp.s.p..p..su.pp.lh.ptlspp..u.h.lppFp.ptPSLs-IFlcpV	....................................................Gslp-l+pp..aGp...pc...lhlp........oc....tshpc.........Lp.sl....................sl.pps.........p.h......p...p....pG.....h..p...lp..lc...s..-..s.......su...pc.lhphlspp.uh.lppFp.ptPoLp-IFhpt......	0	107	202	246
+13575	PF13733	Glyco_transf_7N		N-terminal region of glycosyl transferase group 7	Coggill P	pcc	manual	Domain	This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.	21.30	21.30	23.20	22.20	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.83	0.71	-4.80	4	775	2012-10-03 05:28:31	2011-01-26 16:12:21	1	14	122	59	468	672	185	120.50	40	36.04	CHANGED	CPphsPlLVGshpV.Fp.VPSLs-IVcpss+l.PGGRa+PsuC.sRs.....RsAIIlPaRuRccHLRlLLY+LH.FLpRQQLsYGIaVIcQtGNGsFNRAKLLNVGhhEALp...aDChhLHDVDLLPEND+NLYsCs.p	................................................................................................h.........t........l...GG.pa.p.P....pCh..stp...........+lAl.llPa.R......s............R....p..c.HLhhhl.aLH.PhL......pR....Q....p....l....casIYVlpQs.s.s..t...h.FNRAtLhNV...Ga..h...EA.h+..c........s.....a..D..C...hlFHDVDLlP.s.D+.NhYtC........................	1	160	192	326
+13576	PF13734	Inhibitor_I69		Spi protease inhibitor	Coggill P	pcc	manual	Family	This family includes the inhibitor Spi and the pro-peptides of streptopain (SpeB).  SpeB is produced as a 43 kDa pre-pro-protein, which is secreted via the recently described Sec secretory pathway Exportal. There is tight coupling between this inhibitor and its associated protease: the gene for the inhibitor Spi is located directly downstream from the gene for the streptococcal cysteine protease SpeB, and the sequence of the inhibitor is very similar to that of the SpeB propeptide. This is an example of an inhibitor molecule that is a structural homologue of the cognate propeptide, and is genetically linked to the protease gene [1].	21.90	21.90	22.10	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.30	0.72	-3.88	3	136	2011-01-26 16:26:11	2011-01-26 16:26:11	1	5	74	14	8	126	3	109.20	27	17.66	CHANGED	M.........................................E.pF.RopsEAhtlApoFhupssp.................oKspLRlppLS..hPsDT......LaIlAL.s.GGFlLVSGDTRh.slLuho.csNLDhspssV.shlsVFtcQl....................................NFu-	.................................................t..........pAhphA.p.ah...tps.t..t......................pp.hp...h..psp.thu.........ss..ss..............shYlaNh...sss.GFVIVSGDcRss.pILGYSppGsh..D..h.s....p..t...N..ltsh..hpta.p........hth.........................................	0	2	6	8
+13577	PF13735	tRNA_NucTran2_2		tRNA nucleotidyltransferase domain 2 putative	Coggill P	pcc	Jackhmmer:C2JK63	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.52	0.71	-4.39	46	1530	2012-10-01 20:28:14	2011-01-26 17:21:14	1	13	1500	6	255	1460	430	149.20	25	36.36	CHANGED	hphpspppuWuhLhhtls.h...ppspsFL+sWKhSNchI+pVppllphlphhp.......ppphsth....pl.....YphGpp...hhhhs..ppl....tph...hs.hs............hsh........pplppha..psLPI+.......s++-LslsGtDLlpthshpPGPhlGclLpplEptllpGclsN-cculhpas	.................................................................................................................hhh...t..........pp...spthL+.phKhS.N.p.h.h+p...l...ppllp..hhphh............................ppphp.ph.........l...................Yc.h.s.hc...........hhhps....pl...........tps....ht.ts...........................................ssh.....................ptlpchh.....pp..L.....s.....l.+.....................s.p.+..-....l.....s.....lsGscLlpt.h.uh.p....s.GPh.lG-lLpplEtullp.Gpl...p.Npcctlhpa.......................	0	109	180	216
+13579	PF13737	DDE_Tnp_1_5		Transposase DDE domain	Coggill P	pcc	Jackhmmer:Q6D6U8	Domain	Transposase proteins are necessary for efficient DNA transposition.  This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	27.00	27.00	27.00	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.34	0.71	-3.91	55	810	2012-10-03 01:22:09	2011-01-26 17:53:35	1	3	314	0	228	802	109	97.70	47	42.18	CHANGED	hpRGSLThWlDpch..tW.hs..s.p.G+RGRsptaSDsAIpss.LhlKslFsLPLRtspGFlpSLhcLssLshssPDaSolsR...Rt+slsVslsh+ssstu...lHLllD.STGlKhhGE	...............................hpRGulThWlDtcs..tW.tt...spp.spRGRsppaSDhAIpss.LhlKplFphsLRtspGFlsSlh.pL.hsl.sltsPDYos...lSR...RtKplslsh..............p..s.scu......hHLhlDuTGLKhhGE..................................	0	16	73	111
+13580	PF13738	Pyr_redox_3		Pyridine nucleotide-disulphide oxidoreductase	Coggill P	pcc	Jackhmmer:C2JNY9	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.64	0.71	-4.26	38	7189	2012-10-10 17:06:42	2011-01-27 11:41:36	1	104	2015	19	2924	28500	10134	196.30	22	41.32	CHANGED	hVlGAGssGhuhs.stL....hcp..sh......s.s......llllD....pttp...sGup...at...p..h..h..........spl..hp.....P.uh.h........shs...h........shtth.shsst.s...th....h...tph....sous-.l..s.p...........Yhpplhcph....hl..s.......lp..htspls.tl...p....ts................s..st...ap..lps..ps..t..................plp...sctll.usG...hhtp..P..ph..s..hsu................s....t....ps.l...ths....pl..hsh..t...........c.....h..ts.....pphsVlGuG...+oAhssshtLhct.....u...p......c...lshlt.ppsshh	................................................................................................................................hllGu.G......uG.luhu...hp.L........ppt....Gh.......p................................hhllE.....................p..t....t...p.........h.G..us..........Wt.........p.....h.......................................................................................h.....................s...s.........................................................th....t.h.....s.h.t........................................t............pt.h......................ss...t....s....c....l.......h....p........................................................................................................Y..l...p....p.....h.......s...c..c.a............sl...p...............lp...h..s...s...c.....V....p....s.s......p.......hs................................................s..sp.......ap......lps.....pss.....................................................php.......uch.llh.AoG.....h.h.sp.....P...p..h...P.s....lsG.........................................t.....t........ph..h........H..s.s..............pa......pps....h..........................s.......h....p.u..............++V.s.VlG.uG..........s.SA.......h..p.hs.....p..lspt..............u......t..............p..lshh.Rp......................................................................................................................................................................................................................................	0	721	1687	2444
+13581	PF13739	DUF4163		Domain of unknown function (DUF4163)	Coggill P	pcc	Jackhmmer:A7HM60	Domain	The structure of this domain is and alpha-beta-two layer sandwich, identified from a Fervidobacterium nodosum Rt17-B1 like protein. The function is not known except that it is found in association with Heat-shock cognate 70kd protein 44kd ATPase, Pfam:PF11738.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.40	0.72	-3.23	48	615	2011-01-27 14:33:03	2011-01-27 14:33:03	1	13	479	2	148	539	7	102.50	19	37.12	CHANGED	slphpphp...hp..s..shhp..h.plphPhlps.hp.spphppplNphl..cppstph..............hpc.........h....c....ct.upc.....th.......cpshs........hs..Ythps.....saplphs....ssshLSlhh.shYpYo.GGAHGhTs	............................................................................s.........p..p...hhp..h.plphP.hp.....s...t..spp......hp......p...p....l..Nphh...pp.p.spph..........................hpp.........h....p....pptpc...........ht.............pps............hs...aphps.....saclphs....psslLSlhh.shYpYs.GGAHG.....................	0	60	110	125
+13582	PF13740	ACT_6		ACT domain	Coggill P	pcc	Jackhmmer:Q6D7R4	Domain	ACT domains bind to amino acids and regulate associated enzyme domains.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.02	0.72	-4.26	82	3060	2012-10-02 00:29:19	2011-01-27 17:00:36	1	22	2494	6	650	2293	345	75.40	27	39.29	CHANGED	phLlIoshGpD+PGlssplsplluptsssIlDsp.AhltsphoLhhLlpss.........ts..sh..splppsL.hhupchsl....tlhhp	...........hlITllGtD+sGIlsslophlupt.s.....sNI..hDh..p........s...h....l....s......s....t....F..o..h..h.hlls.ss............ts...sh....s..tlc..ssLtth.utplsl.l.h................................................	0	198	402	547
+13583	PF13741	MRP-S25		Mitochondrial ribosomal protein S25	Coggill P	pcc	PfamB-B_2836 (release 25.0)	Family	This is the family of fungal 37S mitochondrial ribosomal S25 proteins.	25.00	25.00	25.10	25.90	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.54	0.70	-4.89	31	140	2012-10-03 14:45:55	2011-01-28 09:39:44	1	4	131	0	108	137	0	205.30	38	81.68	CHANGED	M..KlphpAspVhppsos.lpu....GhlpppPsWaslVushPPsp..phsRp.hhpp..sppphtph...tp..................hhcsp.pth..+pppssplapss+lpa.EDpLRchFa+pHPWELuRP+lllEss....Gc-..tchDWS+.hpQhsKsLDGESVVQRsLaLlps.....pshohhcAYDhARhEFY+LRhpEEl-ppVAtEEAchaGAsFusopl-hGhphEpchl-sWcphApppoplhpuc	................................thphpAhp.Vhpps.t.hps.....Gh.h.....pptP....sWhsllsslPPsp..hhsRp...pp..stphhtp.......................................hps.p..t.....ppppspclapP.c.lpY...EDpLRp.Fa+-HPWELuRP+lllEss.......GpD..pphDWS...+.lp..Q.G+.LDGE.............SVVQRpLaLhps.................tshohtpAYDhARtEFYpLRhpE-lEp+VAtEEAchhGAhFG.s..tlphGhphEpp.h-pW+thAtpcsphhpt.t.........................	0	28	59	92
+13584	PF13742	tRNA_anti_2		OB-fold nucleic acid binding domain	Coggill P	pcc	Jackhmmer:Q5FCF9	Domain	This family contains OB-fold domains that bind to nucleic acids.	27.00	27.00	27.00	27.00	26.60	26.80	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.21	0.72	-4.14	80	4104	2012-10-03 20:18:03	2011-01-31 09:50:30	1	5	4053	0	822	3044	1031	97.40	34	22.09	CHANGED	hhols-Lsshl+pslcs.s...sphaVpuElSshpt...ps.GH..hYhsLh-............sp..Aplpushapsphptlp.........hp...............................psGhcVllpuplsaat.hG.....hslhlpclcs	............hoVopLsphl+thl-p..c..h..spValpGElSNhpp...sS..GH..hYFoLKD............cp.......Aplp..sshF+..ss..sp+ls...........................Fps..........................ccG.pVlVpuclolYEspG...........sYQlhlcphp.............	0	260	536	693
+13585	PF13743	Thioredoxin_5		Thioredoxin	Coggill P	pcc	Jackhmmer:Q5HAE0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-10.83	0.71	-4.71	36	777	2012-10-03 14:45:55	2011-01-31 10:34:12	1	1	761	6	119	791	73	177.00	31	71.20	CHANGED	YlFlDPlsscCaphEstlpKLth-.....Ysphhpl+alhhspLpslsttttp......................hshssssh..hpp.hsssY.uuLAhKAApLQG++tGtpFLpcLQctlhlp+pslop.-llhphApps.GLDl-.FpcDhcSshApcuapsD.+lupEMsVppsPThVhFN..ps.c-pGlplpGhhsYcla.p	.....................................................................................................................................YhFhDPhsssCaclcshlh+Lph-.....as..p...h..l...p...l..R....a..Ihs...s.....s.l..p..s.lsps.tp....................................ths.p.h.....p.pss..s...s..h..as..s..u.L....A..hK...AA.c.L...........Q.........G..+.c......cu.c.c...F.L.c.tl...Qptl.hlppps.hss.......ph...lhch....h......pss......G.....lDl..-....hF+c...Dh...p...o...st.h.p.c.uhp....p.Dh....+lA.pE.MpIpptPolVhFs...ps.c-pGlhlpGhhshchh...........................	0	33	73	99
+13586	PF13744	HTH_37		Helix-turn-helix domain	Coggill P	pcc	Jackhmmer:Q5HBM9	Domain	Members of this family contains a DNA-binding helix-turn-helix domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.09	0.72	-4.17	55	1158	2012-10-04 14:01:12	2011-01-31 10:40:40	1	9	818	4	307	2718	211	79.70	24	74.93	CHANGED	lapDhuhscucphp.....hKupLhht....ItchlcpppLoQpcAAphhslspPclSplhcu+lsphSl-pLhshLstLGtcl-Islp	...................................................pttt...t..............h+s.p.lh..ht..........lp.phh.cp..pt....h...o..QspsA.phhGloQPpl.Sc.l.p...t...+...h....s....p...h...s...l...ssLhphl.s.t.h..Gt.clcl.h........................	0	67	178	251
+13587	PF13745	HxxPF_rpt		HxxPF-repeated domain	Coggill P	pcc	Jackhmmer:Q6D9B1	Domain	This family is found in non-ribosomal peptide synthetase proteins, and can occur up to twelve times.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.81	0.72	-3.67	1348	6665	2011-01-31 11:02:57	2011-01-31 11:02:57	1	1095	1165	1	2334	7456	120	92.30	29	5.06	CHANGED	sHQDlPFEpLV....-t.L..p.s.p....R.shu...+.s...PLFQVhhsh..p......s..s.....s.......t....s...t.........h.p.l.....sG.......L..p.lp...sh...s...h..s....t..s.....su+FDL....slpl.tE....ps......s.......s....lpsshpYso-LF-psTlpch	...............................tHQDlPFEpLV.......-t.L..p.....s..p..............R...sh...u...........+..s...PL.FQlhhsh.p..............s.t......s...............t.....s.t.............................h.p.l........su..............l...p..lp.....s.h........s.....h...s.......s..s......................su+F.....DL....slpltE......ps..........s...........................s..lpsshcYso-.LFctsTlpph............................	0	609	1300	1915
+13588	PF13746	Fer4_18		4Fe-4S dicluster domain	Coggill P	pcc	Jackhmmer:Q5FDF3	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.46	0.72	-3.55	40	1675	2012-10-03 08:56:43	2011-01-31 11:20:17	1	15	1374	0	499	3018	1748	74.80	36	17.46	CHANGED	lChahCPasR....................hQ.usMhDp...colslsY....................c.ht.hp........................scs..........................ct....ttpp....hcphp...........................pst....shGcClD..CstClpVCPsGIDIR	.................................................................................hChahCPasR.............................hQ..ushhDp.......so..hh.ls..Y.................................................................................c..hc.tt........................tpt...........................p........hh+t...hcpht...............................................c.tt.....shG-ClsCstCVplCPsGIDIR......	0	164	331	422
+13589	PF13747	DUF4164		Domain of unknown function (DUF4164)	Coggill P	pcc	Jackhmmer:Q5HAR4	Family	This is a family of short, approx 100 residue-long, bacterial proteins of unknown function. There is several conserved LE/LD sequence pairs.	27.00	27.00	27.00	27.10	26.80	26.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.84	0.72	-3.85	32	182	2011-01-31 11:46:12	2011-01-31 11:46:12	1	3	165	0	69	156	20	88.10	45	84.00	CHANGED	ssssplptAhpRLcsAlspLEsAl-pRh-tccst......s-hcscl.ptlssDRuRLApELDputsRsp+LccsN+ElucRLssAhEoIRuVLsc	................s...stLcpALcRLcpAlssLEpAV-hRl-.p-pch........uEhEpEl.Q+hsADRSRLApELDpu-uR.u.cRLEtsNREVS+RLs....oAMETIRuVLD................	0	12	39	48
+13590	PF13748	ABC_membrane_3		ABC transporter transmembrane region	Coggill P	pcc	Jackhmmer:Q6D8M5	Family	This family represents a unit of six transmembrane helices.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.37	0.70	-5.33	20	130	2012-10-02 13:23:42	2011-01-31 14:29:18	1	3	117	0	24	160	15	207.20	47	78.77	CHANGED	L+pIs+patt+LhlTasLVlAENsLhlhYPLhuGFAIsullsGsstpAlhYuslVllhWllGuuRRtlDTRsFuRIYscLAVsVllsQRppstssSolsARVsLSREFVDFFEpHLPhLhTSllSlsGuslMLLslEFhlGlusLslLhhhhhllspas++NppLat+LNNcL.....E+-VsllspsptpsLp+HYchLu+LRItlSDREAhuYhhIGlstulLFshslhhhohpssssAG	......................................LKtlsppa+K+LhhTF.LVshENl.LhLhYPlhuGaAIN....A....l.......l.s.G.p.s.......hpA....l.h....Y.A.ll..V...llh....WllGAARRhs....D....TRTFs....RI....Ys....cl.........AVsV....l......l.p......QR......p.......p..........p..h..spS........sls........AR......V.....u......L....S....R.E.F...V.s.FFEcHLPhhhTSllSlhGAslMLLllEFWlGluul...s...ILshhhhl...LPpFsth.......s-pLah+LNNpL............E+-schlppu..st..ppLhRHYshluRLRlhlSsREAhuYLslGhuhulLFuhshshhohpshsoAG..........................................................	0	5	10	18
+13591	PF13749	HATPase_c_4		ATP-dependent DNA helicase recG C-terminal	Coggill P	pcc	Jackhmmer:B0G2L3	Domain	This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	25.60	25.60	25.70	25.60	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.56	0.72	-4.19	156	1792	2011-01-31 15:44:31	2011-01-31 15:44:31	1	38	1018	4	435	1610	115	86.20	24	18.82	CHANGED	GsplplplacDRlEIpsPGslhsslshcp...hhst.s......spsRN.hlAslhpch.............s.......h............h.......E......ptGoGlp.+lhpthcp....tthstPpa.p.s...ss..sp..hp..Vsl	..........................................lplpha....sD.RlEltsP..Gsl...sloh.....-p.....hhst.............stsRNshluplhpph.............s.......h.............h.......E......phGsGlp.+.lhpthpp....hth...tPph.p..p..pt..st..h..hh.........................	0	146	311	382
+13592	PF13750	Big_3_3		Bacterial Ig-like domain (group 3)	Coggill P	pcc	manual	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	27.00	15.40	27.10	15.40	26.90	15.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.96	0.71	-4.80	8	166	2012-10-03 16:25:20	2011-01-31 16:04:29	1	38	89	0	42	589	311	132.50	27	12.60	CHANGED	ssaphsFshssLP-GpYollt.sApDpasN...ssspoht.sltlDsTsPolsl....ttslu-GuslpGLEsLcIoLsDshssu..sLoSlsLsGGPssDpVpLoWsstGcshYtLpYPRlFPSL.csGEoYTLTVsApDstGNssspossFpYhPsNLlplcsL	...................................................hthpas.h..p.tls.-G.pY.s.l.s.s..tApDthsN.....sss.p.s.ht.....p...l.......s.h.D.s..T.s..P...sl....sl........tss...s..s..ss..s.....l..s.l....-...s...l....h...I.s..l..s..D.shs.s...pls..ph...t..L..hGG.ss...s......-..t..l....pl.sh........u.ps.h...a.h...pYs.h...h..F...P..s.........h..p.....s.p..Y..plss.s.DttuNhhp....ts.tFpY...P.............................................................	0	6	17	34
+13593	PF13751	DDE_Tnp_1_6		Transposase DDE domain	Coggill P	pcc	Jackhmmer:B0G2Q7	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.66	0.71	-4.12	60	2925	2012-10-03 01:22:09	2011-01-31 17:05:27	1	17	1173	0	565	4140	496	101.80	25	32.07	CHANGED	hCPtGpph.phptp.thtt..t.p..s.hs...thht.aps..p..sCpsCPh+ppC..sps........pp..sRpl...ph.p.p....h.pp.h.t.pcsccp...h...poc.ttpphhppRs.slEsshupl+pphuhc+h.ph.RGhp+sphphhhsshuhNlc+lh	..............................................................p..t...............................t......................t...Ct..t..C....h........C................................t.....hh......hp.........pt..h...t.tp.hp..pt..........h......ho..t..t....s.p.p.h..ht....p.Rp.slEtsF.uphKph.h.Ghc.+.h..ph....RGh.pp..............sphphhlshhuhNl+Kh......................................	0	215	392	444
+13594	PF13752	DUF4165		Domain of unknown function (DUF4165)	Coggill P	pcc	manual	Family	\N	25.00	25.00	25.00	95.80	24.60	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.54	0.71	-4.36	10	99	2012-10-03 16:25:20	2011-01-31 17:26:11	1	4	41	0	8	59	2	123.90	43	11.92	CHANGED	ssApAplhpYSFTDTsusp+olpPuo.salNPs..oslolsL.uGLDRhl+loVh+ouush.hhoosTo+lhsAschlossGs-YYGKclsLPAL.uEGsaoL+sElLsssGssVuopsYslsIDTTuP	.s.sApAplhEYoFpsssGsp+olsPss.sYlNPs..uslolsL.uGLDRhl+loVh+usGo..lhSTsTo+lhsAschhussGp-YYGKclsLPAh.uEGsaolcs-ILs.sussVsTssYshtlDsTPP.......	0	0	0	3
+13595	PF13753	SWM_repeat		Putative flagellar system-associated repeat	Coggill P	pcc	Jackhmmer:Q6D875	Repeat	This family appears to be a repeated unit that can occur up to 29 times in these outer membrane proteins. It is putatively associated with a novel flagellar system.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.64	0.70	-5.38	14	4913	2012-10-03 16:25:20	2011-01-31 17:42:37	1	401	519	0	1126	8114	1151	233.00	21	45.74	CHANGED	TPss..pp..ssssh..plsls...lpDssGNss..s.s..o.....ts.hs.lDTc.......PpVsls....Iocscl.sutpssssh...oFotssos.hsssshh.hsss.....s.Gsh.....GuL....o......ls.osG.p.Wossh...TP.........ps..slpsu.-soI.pVs..hVpDstGNu..............s..su..sossh.oIDTt.......PpVoVo.............Ioss....cltuGpssTsTFTFsEsV..o.GFstsDs.sho.....sGThG.LssVG...oDGhsWosshTPps..spss-s....slpVs..As.VpDAtGNAs...ou.....S.s....sa.olDT......ps.Pplolsh...uDshls....usEsus.Thshotsls.shsssDs.h.....sos.pG..s...hss.T.....sVss...su..p.aosshssts..stssssT	.................................................................................................................s.................................st.................................h....h...............s..............ht.......................s...............................s.............h......t................s....h..p..................h........t..s..s....t.....t.l....l.h............s.G.t....................h.s.h............s.........hs...ssG.....s...Woh.sh........ss....................................s........sL.ssG...s.h...s..l....sss........ss..D.hs....G.N.s..........................................................s...ss.........o.h..s.h..sl.D...st...................s..s......l...s...l...s..s..................................................................................................hs...ss.............s.l.h..s..s...s...p......h.......s..........s....h.s....s..t.s......s..s.h......t.s....s...p....h....l..p.lsh...........sG...t....h...h.....ts.s...st............s..s.G....sW.s.h..s.h....s.s..s.........t....h.s.su.............sh..s..ls.....ss....spD.huGNss.....os......s..................sh...s..l...D..s.............th...s.....s.....h.....t.....h.....s.....................t........t............................................................................................................................................................................................ss.......................................................................................................................................................	0	251	639	891
+13596	PF13754	Big_3_4		Bacterial Ig-like domain (group 3)	Coggill P	pcc	Jackhmmer:B0G3A4	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	30.80	30.80	30.80	30.80	30.70	30.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.88	0.72	-3.64	416	7056	2012-10-03 16:25:20	2011-01-31 17:55:29	1	431	622	0	1020	10654	674	55.10	32	17.22	CHANGED	Gp.s.h...s..s.ss....s.....ss.....GsWo...h.....s.....s.....s.....ss...s.......-G....s.a..s..lo..l..suoDsAGNs.u.ss..s.s.s.....l..s.l..Dos..sP	.........................................................s..s.s.s.....s........ss...GsWo....a......T.....s.............s........ss..hs............-G.....s.a...s..lo..l..sAoD.s..AGNs.u.ss.......s.s.h.s...l...s..l......DTps..............	0	174	349	751
+13597	PF13755	Sensor_TM1		Sensor N-terminal transmembrane domain	Coggill P, Eberhardt R	re3	Jackhmmer:A3JX63	Family	This domain is found at the N-terminus of the sensor component of the two-component regulatory system. It includes a transmembrane region and part of the periplasmic region, which is likely to be involved in stimulus sensing [1].	21.90	21.90	22.40	22.60	20.80	21.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.40	0.72	-4.47	43	271	2011-02-02 10:44:03	2011-02-02 10:44:03	1	3	271	0	92	230	114	76.40	43	13.15	CHANGED	RtRRuhhslptSsLTR+IlshNLlALslLVuGlLYLNphR-uLltpRspuLlopuclIAsshtAp...ussssshsosDs	.........h..t+hhhphhhSSLTRRIlhlNLhALslLVuGILYLNQFRpGLI-A+lpSLhsQucIIAuAluAS...usssss.hhhDs...............	0	27	58	69
+13598	PF13756	Stimulus_sens_1		Stimulus-sensing domain	Coggill P, Eberhardt R	re3	Jackhmmer:A3JX63	Family	This domain is found in the periplasmic region of the sensor component of the two-component regulatory system. The periplasmic region is likely to be involved in stimulus sensing [1].	29.70	29.70	30.20	29.70	29.30	29.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.46	0.71	-3.68	35	203	2011-02-02 10:46:24	2011-02-02 10:46:24	1	3	203	0	75	162	67	111.60	43	18.97	CHANGED	lsPEpVuPlLRRLhsPT.poRARlYDt-GpLlh....DSRsLh.....spuplhph-LP.Psc.sppsshhcphhphhpphh.ts...............cLPlapE.hssssGptasEVtsALsGp.hssslRhspcG	.......INPE+VuPlLRcL...ISPT.pTRARIYDppuslLL....DSRsLY...........upGtVlRaDL........P...Plc..s.c..........p.ss.lh.......ERhhshlpphh.su...................sLPlYpE.tssusGtsY...EVhpAL.s.Gs..tsshRhsp+G...........................................	0	23	45	55
+13599	PF13757	VIT_2		Vault protein inter-alpha-trypsin domain	Coggill P	pcc	Jackhmmer:A8MTC4	Domain	Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition [1].  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.	23.00	23.00	23.10	23.00	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.48	0.72	-4.52	10	116	2012-10-10 13:59:34	2011-02-02 13:41:04	1	10	54	0	56	544	59	76.80	45	8.33	CHANGED	PGLlNhpotss...............LPLpuSclsuClpGhuLuhTAoLTYtNspstsl-Gs.FlaPLs-sssVlGF-AhluuRhlssplppcs	.................................................PGLhN.tohss...............................LPLosSsVsuClsGhsLulTApLTYtN..p.s...p.P...h.-Gl..FVYPLsE.spsVsGFEAh.lus.RhVohQlps+.u..............	0	11	18	34
+13600	PF13758	Prefoldin_3		Prefoldin subunit	Coggill P	pcc	Jackhmmer:P43573	Domain	This family includes prefoldin subunits that are not detected by Pfam:PF02996.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.10	0.72	-4.22	23	73	2012-10-02 17:27:01	2011-02-02 13:51:44	1	5	73	0	60	162	0	97.40	41	15.65	CHANGED	pcSlh+W+ph.u...EY-uLK-ElssL.............scsuop--llcluR-FsGoLVsEcElctILGc...pp...slpRo+pQVl-lloRRIDYVppNlsTlEKRlcsAEs+Ls	..........................................pcSLhHWphW-AEY-uLKEElpsL.....................sssp--...llc...Iu....R..-...F..s....GsLVsc+ElctllGc...pp....thpRotpQllshlsRRlDYVppNlsoLEKplcsAEs+L............	0	10	27	47
+13601	PF13759	2OG-FeII_Oxy_5		Putative 2OG-Fe(II) oxygenase	Coggill P, Eberhardt R	re3	Jackhmmr:A3JXF3	Family	This family has structural similarity to the 2OG-Fe(II) oxygenase superfamily.	27.00	27.00	27.10	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.37	0.72	-3.73	92	313	2012-10-10 13:59:34	2011-02-02 14:23:49	1	52	193	4	101	350	4039	98.90	26	31.52	CHANGED	ssWsslhp.pGshpssH...hH...ssu...hlSGshYlpss.p..ss............u......shph.ssc........hshh..hs.s.s.h....t.....t...t....tshhh....lpPc.s.GplllFPSaLhHpV.hs.tuc..tpRlSluFN	............................t.hWhsh.hp.pG.shpssHhH....ssu...hlS.....GshYlp.hPp....ss...........................u......shth.ssc..........tthh....hs...t.s.........t......t..t....h..tshhh....hpPp.sGplllFP.SaLhHt...V...s.......t......up.......p.....pRloluFN....................................	0	39	72	89
+13603	PF13761	DUF4166		Domain of unknown function (DUF4166)	Coggill P, Eberhardt R	re3	Jackhmmer:A3JYW7	Family	This domain is often found at the C-terminus of proteins containing Pfam:PF03435.	23.00	23.00	39.70	39.60	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.14	0.71	-4.36	56	283	2011-02-02 14:29:42	2011-02-02 14:29:42	1	4	268	0	77	250	15	170.60	31	72.13	CHANGED	LsstlpchHuh....tss...s..hhpGpsclt..tusp...hhs.....+h.lstl.....ht......hP.....psupplPhplphps.....sss...up.....pWpRpFst.........ptFcSph.h...st..s...sshlhEthG.....s...hthpls....lps....p.s.GuLchpspp....hph....hG....lPLPth.Ltspupsp...Ethc..-......spapFcVclphPhlGh.lhpYpGphp	.............LtPtlpcpasl.......psshshpGphcph..huus.....hhs.....+h.lhtl.....ht.......hP.....cpGpclPhslpsps.....pts..sp.....pWsRpFhh.t.h.+hFsush.h......st..p...........pstll-ahG.....t...lthpLs...lps..............c.p.GulphpSpc...hh......hG...hlPLPpa...Lh..spupsh...EphD..-......ppF+hcVpVpsPll.Gs..LhpYcGpF...	0	18	47	62
+13604	PF13762	MNE1		Mitochondrial splicing apparatus component	Wood V, Coggill P	pcc	Jackhmmer:P24720	Family	MNE1 is a novel component of the mitochondrial splicing apparatus responsible for the processing of a COX1 group I intron in yeast [1]. Yeast cells lacking MNE1 are deficient in intron splicing in the gene encoding the Cox1 subunit of cytochrome oxidase but do contain wild-type levels of the bc1 complex.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.68	0.71	-4.12	10	32	2011-02-02 14:48:45	2011-02-02 14:48:45	1	1	31	0	20	30	1	146.20	25	23.00	CHANGED	s.hpsShhGslhsNLpshpcaIpsHhsYhpppshspshpslFlNslLsHlslapNaouhlphLcsl........phlpssshs...sahcssoF+lIhpSl.SNSsSuKlsuhtLasaLKp..pcl.........plTscsYpsLlpusL+G....ta+-sl.FYlYcYLpsa	....................h.s.phusl.hNLpshpcalpph.p.hpt.pshppsh+shFIsslLsHls.stpsashhlsllcpl.........hL.ssslh...s.hcssoa+hlh+uh.SpssSsKhshhtLasaLpp...sh.........phospsahphlpsshph......p-hh.Fahaphlhs..................................	2	2	9	19
+13605	PF13763	DUF4167		Domain of unknown function (DUF4167)	Eberhardt R	re3	Jackhmmer:A3JZ71	Family	\N	25.00	25.00	35.50	35.50	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.78	0.72	-3.96	45	295	2011-02-02 15:58:01	2011-02-02 15:58:01	1	1	292	0	94	262	1061	82.10	52	35.05	CHANGED	RuR......s.pss..........p....spt.ppss..Ns..hsR..sa...-S....sGPDs.KlRG..oApplhEKYppLARDAtuuGDRVhAENYhQHAEHYhRllsst.ptptp	...............................sRs.pss...........s....Np.s..+pss...Ns.....hsR..sa....-S....NGPDl.KlRG..sAQpIhEKYtpLARDApuSGDRVhAENYhQHAEHYhRllsuAptp........................	0	26	59	71
+13606	PF13764	E3_UbLigase_R4		E3 ubiquitin-protein ligase UBR4	Coggill P	pcc	Jackhmmer:B3KMT2	Family	This is a family of E£ ubiquitin ligase enzymes.	23.00	23.00	41.20	31.10	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	802	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.72	0.70	-13.40	0.70	-6.66	16	189	2011-02-02 16:43:37	2011-02-02 16:43:37	1	17	115	0	133	204	7	616.10	39	20.09	CHANGED	MspNPYSSs-.ulGPLMRDVKNKIC+ph-LluLLEDD.GMELLVsspIISLDLsVpcVYEpVW......................pts.......tp....................ssPMslsYRhpGL.G-ATEphI-pL...pssp-EppDsEtpaphAulh.p-CGGL-shLshltplp.c......hpusp-hlshlL+LLhaCsKl+pNRptLLp..lGALshLLcshppAassss.......htluEplL......................hIhEollpEAs.pssluts.s..hpsss..............................s..pchlthFL-pls.....ss..hh+sNtp...hctlsRllPhLoaGcspsMcsLlcaF....cPhL.p....F-phDp...............c+.s......s-p.............p..ht..lEsFs+lu-ulcssssGc+LK-hIlppGIsptAhpYlccphsss.....tpp...s.SsEWtphLp+PSLPhlLphLpGLupGH.sTQpt.lc.cshI.slLHtLEpVou.-pcIGoLAENLLEsLuc.ppt.....lsc.....plpplRctT+tEp+RhAhtpREchLpsLGMch....sp...tG..pl..l.su.ssllcshE-lc...E.E-GLsChVCREGYsh+PsclLGlYoFoKRsslss...........sp.spt.pts.....................hsYTTVSHFNllHapCHpsAhR....Lpps....+cEWEuAuL+NupThCNsLhPlhGPpVspusaspslspahsslpslup.tsssphph..hs.aDItLLLsRFApptSFSsDs+GGG+ESNh+hlPahlphshaLLsp.......osstp..R..c....p+s..ltualo.s....sspphhps................shph.....-ss..ahhVhSLhs.pSh-pWpppRhsaLpRhltpuah...pah.pstsssch......................s.pspcp....aslh+PhLlaauLl-pl.phFKhth....................o.ssst-sW.hshpE+LppN.pthlsts+clLphh.-EhhsspDhpEhhDlsG	....................................M.tNPYsS.c..hGP.LMRDlKNKICpph-hluLl-DD..G.MELLVssp.Ilu.LDL.....slt.p..VYcplW.......................................................................................................................................h.p..tp..............................s.sMplhYRhpGL.G-ATE.hlc..pL.........ps.p.p.......pcp...c.E..athsssh.tpssGLphhlphlttlp.p.........................hpp.s..p..lth...l.....lcLh.hssKl.chspp.Lhp....hsslshhLtsh.phsh.stt...........st.sEplL.....................................lhE.lhtcus......tpsht...t.....h.t......................................................................s..p.l.hhlpphs...........ss..hhcps..ph..hptlhRllshLsaGp.ttMthLhphF....pshh.p....apphDt........................pp.p......cp.................p..hh..l-.Fshlstul.........p..p.ss...GtpLKshll.phGlh.ptuhp.YhtpphPsh....................................hph....s.us.hpphlp..pPuL.hlLphLpG..........Luh..t.H.s............TQ........hh...l......s..p..............p...l.s.lHtLEtVu.......u..p.......ptlGs..lAENLL.-sLpp.p.t.............................hspplpth....RctT+tEp+chAhthRpc.LttLGMph....sctG...pl...ssp.sshlpphcc.l.......-..EsGLs.ChlCREGYphpPschLGlYsFo.KRssltt......................hp..p...ptp.............................................................sYoTVoaFNllHhpCHhtAhR.....htps+cE.........W-uAsLpNspTtCNslhPlhG.P............p...Vstusassslsca.s.lpp.h..s........t..tpt.....php....h..aDltLLhhRFAht...tSFpsDstGGG.pSNh+hlPahl.hs.hal.lsp.....................ststtpp......tpt...l.s.alp.t..s..pt..ps................................................shp...-ss..ahhh.uLhh..s..cpWpt..+hthLp+hlhhu.h...pthts.....t.........................................tt.p...a.sh.h+s.Llahull-.l.phhhph........................................................................s.ssp.ttW...ht-hlt.ss..hhthscphlphh.--hhsspshtEhhDlhG..............................................................................................................................................................................................................................	0	62	81	111
+13607	PF13765	PRY		SPRY-associated domain	Coggill P	pcc	Jackhmmer:B0V264	Family	SPRY and PRY domains occur on PYRIN proteins. Their function is not known.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.27	0.72	-4.43	191	3648	2011-02-02 16:53:56	2011-02-02 16:53:56	1	109	99	11	2020	2534	0	48.80	38	9.97	CHANGED	loLDPsTAaspLhLS-Dt+.pVph....sppt...p.shP..-sPcR.Fsph..spVLupcuF	......................lTLDPsTAaspLhL.S..-Dp+.pVph.................sppp...............p...shP....-sPc..R.Fsth..spVLuppuF...................	0	51	592	1270
+13608	PF13766	ECH_C		2-enoyl-CoA Hydratase C-terminal region	Coggill P	pcc	Jackhmmer:B9A058	Domain	This is the C-terminal region of enoyl-CoA hydratase.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.55	0.71	-3.95	180	1675	2012-10-02 13:07:06	2011-02-02 17:12:08	1	13	1322	3	662	1647	343	119.80	30	31.65	CHANGED	sL..ttptstI-chFu.....t....s..olpcIlssLcs.........c....s.s....p.....autpshcsl.ppt..SPhShplshc.lcc....u+..p.........h.o.lt-shphEhpluhpshp....p.........s........DFhEGVRAhlIDKD..+s...P.c.....Wp..sslp-..Vs.ss..hVsphFs	........................................tphshIsctFu........t....s..olp...cIlps...Lcp................................s...s.s....p.....aApp....shc.s....l.tpt..SPhSl.plohc...t.........lpc.....ucp.....................hoLt-shphEhplutphhp.....p.........s........D..FhE.....GVRAhL.....lDKD..ps........P..p.......Wps..sslp-..Vs.sp..VpthF......................	0	192	370	537
+13609	PF13767	DUF4168		Domain of unknown function (DUF4168)	Eberhardt R	re3	Jackhmmer:A3JZQ0	Family	\N	25.80	25.80	26.10	25.80	25.20	25.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.50	0.72	-3.35	72	184	2011-02-03 11:39:14	2011-02-03 11:39:14	1	3	138	0	75	191	5	81.90	23	54.79	CHANGED	hocpplppaApAhlplpslcpchhpc.lps..................sps...................p.pphppl...tpcAppph..............l.........p......tl.cssGLolppaNpIsptspsDs..pLpp+l	.........................................ospplppaApAhhplptlppphhpc.lpp........................sps....................................t.sphppl.......tpcuppph..............s.........phl.pssGLo...lpcaNpIsptsQsDs..pLpp+l......	0	26	61	70
+13610	PF13768	VWA_3		von Willebrand factor type A domain	Coggill P	pcc	Jackhmmer:Q3UR50	Domain	\N	27.00	5.20	27.00	5.70	26.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.94	0.71	-4.53	14	1260	2012-10-10 16:07:06	2011-02-03 14:36:20	1	77	395	0	741	6397	466	152.20	22	18.63	CHANGED	tclVlllDsSss.hpsp.....hhppulshhlcs..Lsspc.plsllshGs..ps..hh.ss....hhshssttlpthhthlps...hps..hGusslhsuLc...tsh....p...t........ttsthhcpllllo.cGs...t..ss....tcs..p.lp.p.t...tc..hphhshuh...ss..phs.s..shLptLAphupGthph	..........................................................................................t.cllhll.DtSuS.M.........p.......u.................hphs...+.......p..s.......l...h...h.....h.....l....cs.............L.......s...................p.......s.......p......F........N.........l..l..s..F......us..........p.h...p...t.h.....h.....s.p................................h..t...h......s....p....p...s....h..p..p...A..h.p...h.lpp................lps....hG.....u...T....p......l....h.....p.....s.L.p............tsh.........p......h...............................ttt...s.p...t....l.h.l..l.T..DGp.....sp......sp.......................p.p..l..h.....ph...l....p...p...tt..................tp.........h+..l..a..o...hul..................Gp............sss...t..........thlp...tlAphst.Ghh.....................................................................................................................................	0	248	375	539
+13611	PF13769	Virulence_fact		Virulence factor	Eberhardt R	re3	Jackhmmer:A3K275	Family	This domain is found in conserved virulence factors [1]. It is often found in association with Pfam:PF02985 and Pfam:PF08712.	25.00	25.00	25.60	32.20	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.60	0.72	-4.12	53	419	2011-09-19 00:13:31	2011-02-03 14:42:30	1	9	419	0	60	256	220	81.70	45	25.41	CHANGED	lha+sIPhQVhlspGcc....ps.+htLP-RFppAls+As....ttssDshlt-h+hs-..sst.G-hp.-lAcssspcl-AsYsp-RLcpLl	....hF+sIPhQlKLTsucp....Eh.RhtLPppFh-shspA.....tpssDNlVh.RKWl-..usRYGshE.ElhcsVlEEllAsYsEppLshLV.......	0	15	36	46
+13612	PF13770	DUF4169		Domain of unknown function (DUF4169)	Eberhardt R	re3	Jackhmmer:A3K2D0	Family	\N	25.00	25.00	32.60	32.50	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.72	0.72	-4.03	82	226	2011-02-03 15:43:01	2011-02-03 15:43:01	1	1	226	0	73	181	5	54.80	44	82.85	CHANGED	u-llNLpphRKp+sRsp+ctpA-pNRspFGRTKAE+phscscsc+spcpLDu+.+h	..u-lVNLRphRKp+uRsp+cppA-pNRlpFGRTKsEKshscspsp+Ap+hLDtpRh..	0	19	42	52
+13613	PF13771	zf-HC5HC2H		PHD-like zinc-binding domain	Coggill P	pcc	Jackhmmer:Q5W0A5	Domain	The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains.  The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.92	0.72	-3.84	144	1247	2012-10-03 17:27:21	2011-02-03 15:57:56	1	127	218	0	775	2477	15	83.60	31	6.32	CHANGED	HhhCuLassplh.ps.stt........slpsl.pphsppthphpCth..Cc........pp.....G.AslpCsttsCppsaHhsCAtpss.hhhp......hp.................t...........................phpsaCppHs	....................................HhtC.hl...aS.stlh.pptst...................t.lt.sl..cp..tlp...c..upph.....cCs.h...Cp.........................ch........G..Aol.u.........Cs....t.p..sCp...psaHhs........CAhp.s...t...sh.hp.........tp....................................................hphhC.pHp.........................................................................	0	191	283	499
+13614	PF13772	AIG2_2		AIG2-like family	Coggill P	pcc	Jackhmmer:B3KMN7	Family	This family is found in bacteria and metazoa.	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.77	0.72	-3.87	26	714	2012-10-02 16:39:48	2011-02-03 16:07:47	1	11	571	11	289	659	306	83.90	29	41.81	CHANGED	cVaGsLaclshpshpsLDppEuVp...pGhYh.lplpV.....ps...pss.pp.lhsRsYhlss...p...ss....s....................PSppYLplllcGAhpsGlPpcYlctL	...................................................................pVaGlLacl.s........p..........-hpsLDphE.G.s.........hthYp.+.hp.lp.V...................ps....tsG.p...l..Ahs.Ylhs.s....h.......ps.....uh...........................P.SspY...Lshl...hc.G...Acps....GhPpcYlp.L...........................	0	97	180	239
+13615	PF13773	DUF4170		Domain of unknown function (DUF4170)	Eberhardt R	re3	Jackhmmer:A3K3X5	Family	\N	25.00	25.00	26.40	25.60	21.10	24.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.24	0.72	-4.07	34	216	2011-02-03 16:14:24	2011-02-03 16:14:24	1	3	213	0	76	162	34	68.60	62	81.17	CHANGED	pQLLHLVhGGELp..c..hss.spF+DLscl-lVGlFPsYssAhsAWKucAQpTVDNAcMRYFIlHlHRLLDPs	.....pQLLHLVFGGELp..c..Lss.spF+DLpslDIVGIaPDYtSApsAWKuKAQpTVDNAHMRYFIVHLHRLLDPp......	0	20	45	55
+13616	PF13774	Longin		Regulated-SNARE-like domain	Coggill P	pcc	Jackhmmer:C9J9A4	Domain	Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterised by a conserved N-terminal domain with a profilin-like fold called a longin domain [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.97	0.72	-4.43	180	1355	2011-02-03 16:49:18	2011-02-03 16:49:18	1	14	344	17	898	1268	11	84.60	23	37.83	CHANGED	hu+.pllp+ls.......ss...s...+tohp.pss.ahhHalh...p......su.................lsalsls-c.sa.s++lAFsaLp-lpc-Fhp............pas..........t.phtsss...sauh.......hpFssh	....................................uctlhp+ls.......ps.....................s+hohp..pss...ahh..H...ahs....p.................su........................lsalsls.-c..sa..scclAFsaLpcltc-Fhp...............pas..........p..phtss.....shsh....pFs..............................................	0	294	502	724
+13617	PF13775	DUF4171		Domain of unknown function (DUF4171)	Coggill P	pcc	Jackhmmer:B0QXZ9	Domain	This short family is frequently found at the N-terminus of Homeobox proteins.	27.00	27.00	36.40	36.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.73	0.71	-3.96	4	63	2011-02-03 17:52:59	2011-02-03 17:52:59	1	2	34	0	25	53	0	128.00	76	23.90	CHANGED	DTAMDLLKAITSPLAsGS........KPSKhhup.ssuSSspScS+KE............HH+KhGsuSo......DssSH+SKK.h.hasss...EsLTLREPDGLKMKLILSPKEKu..........pSSssppuhth.uppAosKKsSKKpuR-Ept	DTAMDLLKAITSPLAAGS........KPSKKTGEKS.Su.S....S....S......HSESKKE.............HHRKKlSGSSGEL...sLEDGuSHKSKKMKPLYVNT...ETLTLREPDGLKMKLILSPKEKG..........SSSVDEEuFQYPSQQATVKKSSKKSARDEQG................................................................................	0	2	4	10
+13618	PF13776	DUF4172		Domain of unknown function (DUF4172)	Eberhardt R	re3	Jackhmmer:A3K4N3	Family	The family is often found in association with Pfam:PF02661.	25.00	25.00	27.10	25.80	23.90	23.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.45	0.72	-3.88	93	374	2011-02-04 09:14:32	2011-02-04 09:14:32	1	4	341	0	117	349	80	79.70	41	22.14	CHANGED	aIWQpscWPpFpWDsppltshLppsphpQGtLlGph..pslu.s.pppstL-sLsp-llcoStIEGEpLstpSVRSSlAR+LGl	.........aIWQpscWP........pFpWDtstltshLppsphppGhLlGch......psls.stppptsL.-sLhpsllpS..StIEGEtLNhtSVRSSlAR+LGl........	0	29	64	91
+13619	PF13777	DUF4173		Domain of unknown function (DUF4173)	Eberhardt R	re3	Jackhmmer:A3K0W3	Family	This domain of unknown function contains multiple predicted transmembrane domains.	24.10	24.10	24.40	24.40	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.45	0.71	-5.01	54	229	2012-10-01 23:40:40	2011-02-04 09:19:05	1	2	227	0	76	246	7	185.70	26	36.61	CHANGED	LsllslLahlasslQlshLa..GG...ssl...ss.GhoYA-YA+pGFapLlhsslLshlhlll....s...pth....hp.....c......sp.....l.l.+sLlhlhsshslllluSAhhRhpLYlssYGLThhRlhshhahhhlul....slllllhplh...tthsstalhptsh.hssssslh.shuhhN.-shIAchNls+..t.....pssplDhpYLs.s..Lu..scAhPultch.	....................................hhlshlahhFshlQhshLa..uu......tth...ss.uh.oY..u.pYA+pGFapLlhlslLshsllhs....s.....phh....sp.....c......p+.....h.l.+hlhsll.sshoh.lllhSAhhRh.slYlptYGhThhRlhshhahhhlsl.hhllllhplh....+th.....tthh........hpt.sh.hs.shsshh.hhshh........s.-thlAphNlpp.....................thtthDh..Ylt.t..Lu...sAhshl....h..................................	0	32	57	66
+13620	PF13778	DUF4174		Domain of unknown function (DUF4174)	Eberhardt R	re3	Jackhmmer:A3JZK5	Family	This domain of unknown function is found in a putative tumour suppressor gene [1] and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion [2,3].	27.00	27.00	32.10	33.70	25.30	26.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.38	0.71	-4.00	85	508	2012-10-03 14:45:55	2011-02-04 15:36:30	1	7	241	0	222	467	183	122.10	31	45.45	CHANGED	ssLspatWppRslllFAssssDsphppQhphLpp..pt...ssLs-RDllllss.sssssps...........................sLRpphc....sps...FthlLlGKDGthKlR....tstPh.sscclhcsIDpMPhRppEh	.........................LspFth+pRlLlloAPsssshhap.QhshLpp..st...CslstR+lsllpl.hssssppss.....................p.hss.th..h.pLRphhpls.....pt...FshlLlsKDGpsKpc....astPl.shptlashIDshPhRppEh.....................	0	17	53	116
+13621	PF13779	DUF4175		Domain of unknown function (DUF4175)	Eberhardt R	re3	Jackhmmer:A3K2P3	Family	\N	26.40	26.40	26.60	26.70	26.00	26.30	hmmbuild  -o /dev/null HMM SEED	820	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.60	0.70	-13.46	0.70	-6.84	55	303	2011-02-08 14:41:21	2011-02-08 14:41:21	1	2	262	0	113	278	125	681.10	30	90.41	CHANGED	ERlh.shWPlhollhlhLuhshhGLaphlssthhhss.lsl....hsluhl.suLhhslh+aRhPsRsEALsRLDt.s.......LstRPlsALtDs.AhGssDssutALWpsHQpRMAsphuph+ushPc.+luc+DPaALRhlAlLhlls.A..hha..u...u..h...hRluslsshhsu.sus..s..u.s.usph-uWlpPPsYTGcPslaL..............s...sts...............ss...........slsVPpGSplolRhhG..........t.su...slsls..........ps.sos..p.s.............ss.ssss...........................s...........sp.......pcFs..lsp.sGslslp..usu.....uc....sWplsllPDpsPpIshss.sPct.sspGshplsapAcDDYGVssucApIs.hsh....s.sssc..p.Ghssc......P.........hhcs.plsLsLPhsusRsshstthlcDLocHPWAsh.VplTLsApDuAGQpGpSpshphhLPuRpFhcPLAtAlIEQRRsLhhstssss.cVsplLcAlohpPEc.hhtstssYLtLRshhpRL-......tu......ho--shc-lsstLW-lAltlEDGsLusAcc+LRcAQ-+LpEAlcpGASD.EEIscLMpELRcAhp-Yh+pLAcptppssp..pt..tps....p....ssp...phoQpDLpcMhDRIpELhcpGchspApphLcpLQpMMENhQssQ.....sQ...t..........ts...p.u.ttp...QuM-pLu-hlRcQQpLpDcsFRphQ-.p...p.....s.......QpGp........p.pspp.sp.............s.pt.Gp...s.Qt.................sp...pttp....sp....stp..........psppsp.........tt......p....p..ttps..............LuccQpsLp.ccLpct.p.ppLsstGsp.uttup-uLscAscAMcsApcALtcGchspAlDpQucAh-ALRcGhcsLuEtM.....tpp..........ptpt....pGt....tspt....t.Gp.....ts..s..pspDPLGRstssp.G..ssss.psh.lssE.shpRAR-lL-ElRRR.G-ssRPplEhDYLcRLLc	............................................................................................ERhh.hhh.hhhllslhhuhuhhGlhthhP...hh....phhhlsh.hshshl.hsl...hsh.p.h.R....Pppt-h...tRl..-..t.ss.....tLsppPlss.p...Dp.A...ss...tcsh....u......A.LWptHppRhttpltplpss.....h..P.c..c.hstpDPauL.Rh.hshlhhls.A..hhh...u.......s.t....tRhupshs.h.ssts......h......ssp..l-.uWlsPPtYTGpsPlaL.....................s...sts...................ts...........slslPtGShl..s..lRhh.G..........tss...thshs......ts..st...t..............t....stt...............................................................s...hp.....hph..p..lpp.stsltlp..u.s...st........pWphsshPDpsPplthst...tP...c...t.....t...h..p.G.p.hpLs..aphpDDYGlsp.upuplh.............s..............t....p......P................hts.phsLsLPhtsscps....h.........pDLopcPaAG..VtlsLsspDsAGppGp.Stsh.hhLPtR.F.pPlAtAlhEpR+.Lshstppt..pshphLpAlh.htP-t.hh.s.shaLtLtshhppLp...............hu...hscp..thppssshhWplAltlE.....p.....G..s.....lu..tApcp..LRtAQptLppAl...p..........p..........s.....A......u...p........pEItcLht...-LRpAhpcahpt.hApp.tpssp.t.....t........tst..hppp-LppMhcplpphhcpGptstApphLp....plpphhpNhp...hsp............sp..p........................ttpsphp...pthp...pLs-hh+cQQphhscoa.pt.pp.php...t............p.st........p..ttt.t....................................tt............................................t.......t....t.....t.............tt.....th.....t....p....t.pp...............................htppQptlp...ppLp.p....pt..h.t.thp..............stps.....hscAtpuMtsAtpALt.p..sp..hstA.stQupAl-uLRcGtpphhptM.....tpt..................................ttt.....t..........stt....t.s......................tttttpDPLGR......t...sp.s...t..sp.psh.lssc..shpRARcIL-ElRR+.upt.pPp.EhcYLpRLLc........................................................................	0	35	71	88
+13622	PF13780	DUF4176		Domain of unknown function (DUF4176)	Eberhardt R	re3	Jackhmmer:D3E5E1	Family	\N	25.00	25.00	25.10	25.30	23.20	24.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.60	0.72	-4.26	56	651	2011-02-08 14:46:40	2011-02-08 14:46:40	1	3	430	0	56	331	1	72.40	40	70.15	CHANGED	lLPlGSVVhLKs..usp+...lMIluRt.hh....psppp...haDYsushYPpGhhs..-pshhFNc-DIpcVlFpGYpD--Ehpat	..............slGSllhLcp....sp.pp...............lMIlsRt.lh....pspph.............haDYsushYPhGhlp..-plhaFNc-sIcpVlFcGYpDp-EhpF..............	0	17	34	45
+13623	PF13781	DoxX_3		DoxX-like family	Eberhardt R	re3	Jackhmmer:D3E5H6	Family	This family of uncharacterised proteins are related to DoxX Pfam:PF07681.	25.00	25.00	25.40	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.10	0.72	-3.66	76	297	2012-10-02 13:32:46	2011-02-08 15:41:34	1	3	292	0	87	289	15	100.70	27	34.60	CHANGED	uhlWlhsGllshhlhs.st.phplLsph.Ghssthushhlhhsu.l.h.-lshGlhhlh.thpp.+.hshhhpl.h.ll.luhhlhsshhhPphahcPasPlsKNlsllsLth	...........................shlWlapGllsth.....lhstst.phplLsth.shss..thu...hh..hlhhsuh.h-lhhGlhhLh...hhpt....+.thhhhplh.ll.luholssu.hhtPthahcPFsPlstNlslhsls...........................	0	21	41	65
+13624	PF13782	SpoVAB		Stage V sporulation protein AB	Eberhardt R	re3	Jackhmmer:D3E7E2	Family	This family of proteins is required for sporulation [1].	25.00	25.00	27.10	26.10	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.34	0.72	-4.08	43	225	2011-02-08 15:45:58	2011-02-08 15:45:58	1	1	225	0	34	157	7	103.60	50	80.58	CHANGED	lssLGllPRhuplT+TtcplhhYEsslllGullGshhsla.chpl.h.....ut.hllslhGLhuGIFlGslAsALsElLNVhPIhuRRlplpptlshllhulAhGKslGSLhaahh	....lslLGllPRLsplT+ohcpl.haEhullhGslhGshhslh.phsh.h.....................up.ahLlllGlFsGhFlGMLAAALTEVLNVLPILAKRlGlc.spIllLLhAlVLGKllGSLFaWl...........	0	10	24	26
+13625	PF13783	DUF4177		Domain of unknown function (DUF4177)	Eberhardt R	re3	Jackhmmer:D3E8A6	Family	\N	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.10	0.72	-4.34	50	606	2011-02-08 15:50:16	2011-02-08 15:50:16	1	2	570	0	167	416	98	52.20	41	82.95	CHANGED	paEYcsltl.ht.tts.......tphcplLspaGp-GWELVpllss.......t.t..t..shhshhKRp	................................pWEYtT.lPlhs..+uo.................cp.......ILspaGpDGWELV.pllsu...................st.-phluYhKR.............................	0	58	133	159
+13626	PF13784	Fic_N		Fic/DOC family N-terminal	Eberhardt R	re3	Jackhmmer:A3K4Q6	Family	This domain is found at the N-terminus of the Fic/DOC family, Pfam:PF02661.	25.00	25.00	25.00	25.50	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.70	0.72	-4.12	115	562	2011-02-10 11:07:32	2011-02-10 11:07:32	1	9	506	2	173	510	92	83.30	34	23.18	CHANGED	llphlspAspALucLcuhsphlP.Nsslll..sshshpEAhhSSpIEGT.oTh--lhph-tsts.s........tss-scEVhNYhpALptGhcp	..................................hptlhpAptuLucLcuhuphlP.N.s..lLl....sslshpEAhtSScIEsh.hoThD-Lhphptptst...............ssss+EVhsYtsALptGhc.............	0	67	135	157
+13627	PF13785	DUF4178		Domain of unknown function (DUF4178)	Eberhardt R	re3	Jackhmmer:D3E9P9	Family	\N	25.00	25.00	25.00	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.82	0.71	-4.19	54	460	2011-02-10 11:12:14	2011-02-10 11:12:14	1	3	375	0	119	366	29	142.20	22	59.83	CHANGED	LtsGDhlph.....s.ut..sahV..pGphp.....h..p.pushpWtEahLp..s.sspttWLslE........--splphslhpphsshs...............sssplph....-GppaphsEpGsAp...hpupussshtsu....sphpah-Y..tusss.phLuhEtass........ph-hspGphlsst-	.............................................Lt.Gshsph..........s.sh..papl..hGphp....................h.......p...ps..t..tWh..EahLp..s..spshtaLplE........-cs.ph...thplhsthssht........................................psssphph.........csp.p.Yph.p-p.....hpup.....sssp.spt.s..h..tsu.......pphphh-a....pusst..thLshEh.ss...................ph.h.pGc.l....t..................................	0	36	62	96
+13628	PF13786	DUF4179		Domain of unknown function (DUF4179)	Eberhardt R	re3	Jackhmmer:D3EAG2	Family	\N	25.20	25.20	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.04	0.72	-3.76	49	573	2011-02-10 11:15:32	2011-02-10 11:15:32	1	7	242	1	126	525	5	99.40	20	25.09	CHANGED	p+h.cp...+p....htp.tth....sh..s...sslh....lh.....l...hs....o......ssaAt.h........ts....l.hph..h.p..p....pGhpp..sh.pptaupt..lsp....oho.spGlplTlscllhDcsplhlhYplc.spc	....................h...pp....+t....hhhpts........su..s....uslh.......lh........h....hs.........s...........sshA.ssls................hhss.....lhph...h.s..tc.............pG.lpp.............sh.pt..th.s..pt...l..sp................ohp..spGlslTls-lhhDs.splsltYplcpt.............	0	57	114	117
+13629	PF13787	HXXEE		Protein of unknown function with HXXEE motif	Eberhardt R	re3	Jackhmmer:D3EB69	Family	This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	25.00	25.00	26.40	26.40	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.71	0.71	-3.72	142	380	2011-02-10 11:30:58	2011-02-10 11:30:58	1	2	312	0	94	360	151	114.00	21	63.39	CHANGED	halh.llahlH.phEEhhh....h.tahspph.th.....................hhosptFhlslhhhhlhhllhshlsth...........hhhhhhlhh..hhphl.hHlh.s.hhh+p..YsPGlloulllhlPhulahh	....................................hlh.hhahlH.phEEhhh........h..a.hpp...th.th......................hhsspshhlslhhtallhhlhshhshh.t.........hhhhhhhta...hhphl..hHlh.....s....hhh+p..........YsPGlhTullh.lPhulhh..............	0	33	66	78
+13630	PF13788	DUF4180		Domain of unknown function (DUF4180)	Eberhardt R	re3	Jackhmmer:D3EBG4	Family	\N	25.00	25.00	36.20	36.10	23.70	22.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.34	0.71	-4.43	45	213	2011-02-10 11:34:24	2011-02-10 11:34:24	1	3	206	0	58	178	5	109.50	43	79.20	CHANGED	hc.psshplshlsucssllsstp-ALD.Lluss.aptssstlhlstspls--FFsL+TtlAG-ILQKFlNYcl+lAllGDhSta..sSpuL+DFlaESN+GpplaFlssh-pAlp+L	............h...sshplshlpsspslIsssQsALD.hhuss.aEtsscplllpcshloEDFF-L+TpLAG-ILQKFlNY+lKlAIV.GDFShY..sS+uL+DFIaEsN+GpclaalsocppAlc+L..........	0	25	48	56
+13631	PF13789	DUF4181		Domain of unknown function (DUF4181)	Eberhardt R	re3	Jackhmmer:D3EC26	Family	\N	25.40	25.40	25.40	25.40	24.90	25.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.20	0.72	-10.65	0.72	-4.13	31	197	2011-02-10 11:38:06	2011-02-10 11:38:06	1	1	123	0	28	151	0	94.60	34	86.50	CHANGED	lhhhhh-phl+KKL....sltKpthh...caVNphHchlEhhl..hllhllsh..hhhhhh.c........h.hthhhhhahslhhshRuaMEWKY.s+-oKc...Yllolhthh...hlllhuhhhhhh	.................hhhp.hlR++L....sh.K..ptha...caVNphHhhhphhl..hhhalls...hhhh...p........h.h.thlhhhahhhhhshcu.aMEWKY.D+ESKEYllSlhshh...hllhhullhhh.......	0	3	24	25
+13632	PF13790	DUF4182		Domain of unknown function (DUF4182)	Eberhardt R	re3	Jackhmmer:D3EDS0	Family	This protein of unknown function contains a number of highly conserved cysteine residues, which may form disulphide bonds.	26.00	26.00	35.60	35.40	25.90	25.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.01	0.72	-4.16	13	277	2011-02-10 11:50:17	2011-02-10 11:50:17	1	1	126	0	21	82	0	38.50	73	89.38	CHANGED	MGTIVCQsCssTIsaFE-EKVTsLYGpCsp.C-Ccppcc	..MGTIVCQsCEGTIuHF.E.D.EKsTVLYGKCGo.CcCc+cEc........	0	3	12	14
+13633	PF13791	Sigma_reg_C		Sigma factor regulator C-terminal	Eberhardt R	re3	Jackhmmer:D3EDV4	Family	This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain [1].	25.00	25.00	25.80	27.10	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.76	0.71	-4.18	37	457	2011-02-10 11:53:04	2011-02-10 11:53:04	1	6	316	0	49	336	1	146.30	29	45.71	CHANGED	plpclspsplsEsulSFD+sYohcE..lpphhspt..........sWhhlcTts-ppppt.t........................ttpshGat....spt.ph....tpp.tp...cpFl....stLchhscppphsphhs............hppphchlpp.pslclhGlllTGpsc-ltpLtspshl+uuslGss	...................................Lpch..pspVsEVAlSFDKsYohpE..lpphlPsshp........lWhh..lsotpc.pcpps.t....................................sttshGFt.........ph.p....p..........t.....p..p..pp...ppFh........ctLc.phspp.pct....p..t.p.............................htpphc....hcp..pslclaGlllTGpocphppLpspsal+uAslGsh.................................	0	8	27	38
+13634	PF13792	Sulfate_tra_GLY		Sulfate transporter N-terminal domain with GLY motif	Coggill P	pcc	Jackhmmer:C9JKR6	Domain	This domain is found usually at the N-terminus of sulfate-transporter proteins. It carries a highly conserved GLY sequence motif, but the function of the domain is not known.	25.90	25.90	26.80	26.80	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.49	0.72	-4.31	377	6864	2012-10-03 01:44:59	2011-02-10 11:55:28	1	50	2950	0	2486	5940	1281	81.00	30	13.90	CHANGED	lP...hl..p.....W......l.p....Ys....p.hl.tsDllAG....lTluhhhlPQulAYA.h.lAG..lP..P.hGLYuuhlssllYulaGoS+plslGPsA.s.h.o.l.l.l.us.s.l	........................h.t........hp.......p.ph...ttDll...AG.................lsVullh.lP..............u........lAa......A..l..luG.........ls...........PhhG...L...Yuuhls.sl....lhu.lhGuSp..thls...........G.Psuuh.ulllssh.h...................................	0	663	1334	2000
+13635	PF13793	Pribosyltran_N		N-terminal domain of ribose phosphate pyrophosphokinase	Coggill P	pcc	Jackhmmer:C9JDH0	Domain	This family is frequently found N-terminal to the Pribosyltran, Pfam:PF00156.	25.00	25.00	25.10	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.32	0.71	-4.35	429	6720	2011-02-10 13:49:44	2011-02-10 13:49:44	1	18	4765	46	1992	4453	2459	117.60	47	35.76	CHANGED	lplFoGsus....pLAccIuctL.........................Gl...Lu..p.......splp+FuDG..........EltVpl..........pE....oVR..GpDVFllQoT.s..........s..............P.lN-sLMELLlhlDAh+RASA.p+ITAVlPYaGYARQDR...................K.sps........RsP.........IoAKL.......VAsllpsAG	..............................................................................h+lFuusus....pL.Ap.cl.App...L....................................................ul..t..LGc......sslp+FSDG..........ElpVpI...............pE.....oV.R....G.p...D.V........FllQST.s....s..............................................P.sNDsL.MELLIMlDAh+R....A.SA..pp..I....o......sV..l..P....YaGYARQ.DR...............................+..s+u........RtP.........IoAK.L.......VAshLpsAG...................................................................................................	0	654	1213	1657
+13636	PF13794	MiaE_2		tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	Coggill P	pcc	Jackhmmer:A0JYP2	Family	\N	21.50	21.50	21.50	21.80	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.07	0.71	-4.80	3	288	2012-10-01 21:25:29	2011-02-10 15:50:20	1	1	287	4	74	200	13	176.30	42	79.12	CHANGED	sRYccuVVDLLGALAYGELSAFERLAEDARhAPTLsDRAsLA+MAuAEF+HYEhLcDRLAuhGl-sE-AMcPFVAAaDsFHupTcPuDWLESLVKAYVGDolAADFYREVAcaLDsuTRELVLsVLDDTGHouFAcE+VRAAlAuDPRLuuRLALWGRRLLGEALTQAQRVVAERDALuoLIlGG	................................................................t.......h.cLhuhl...AYuElu.AF.RLsc-.u.chAPsLssR...ht...lAsMAuAEh.t.H.act.LRstLsc.R.Gs-s..htAM.pP.asuu.l-sa+t...T......s..P...psW...hEu........LVK.sYVuDuLAuDFYpclAssL...s.sp.s+sl.Vt.u....s....L....s.-..TGpupFss....ucVRuAls...A.c.sp.+uRLuLWuRRLlGEAlopAQhlh.Ac+ppLsshlh..s........................................	1	24	59	71
+13637	PF13795	HupE_UreJ_2		HupE / UreJ protein	Eberhardt R	re3	Jackhmmer:A3K636	Family	These proteins contain many conserved histidines that may be involved in nickel binding.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.78	0.71	-4.73	99	405	2012-10-02 18:22:22	2011-02-11 10:42:20	1	4	310	0	155	468	1125	151.10	36	51.33	CHANGED	alhlGhcHll..pGhDHlLFlluLlh........................hhtph+cllhhVTuFTluHSlTLslusLshls.....ls...ut...llE..slIulSIlhtAl-Nl...............hhshh.thphhhshhFGLlHGhGFAshLp.phslspss..hlhsLLuFNlGVElGQlhllshlLhlhhhhpcth	....................................alhlGhcHll..pGhDHlLFLlu..llh.............................hhtph+c.llhhVTh.F.TluHSlTLhl.ushshl.s............ls...sh...llEslIulSIlahA.l-Nl....................thht.ht.tphhsshhFG..LlHGhGFAshLt..-.h..s...ls..p...s..........s..l.lhsLluFNlGVElGQlhhlshlLhlhhhhpp.h.............................................	0	58	109	136
+13638	PF13796	Sensor		Putative sensor	Eberhardt R	re3	Jackhmmer:D3EFN7	Family	This family is often found at the N-terminus of proteins containing Pfam:PF07730 and Pfam:PF02518. The N-termini of proteins containing these two domains often function in stimulus sensing.	26.00	26.00	26.60	26.50	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.60	0.71	-4.67	87	465	2011-02-11 10:52:36	2011-02-11 10:52:36	1	7	224	0	205	504	14	172.20	21	46.00	CHANGED	allhuhshulsshshlhss.lslus.slslhhl..G.lslLssslhss+shuthERtt.spthh..sh.plstP........st......suhhstltshlp.-suoWRslhahll.phsluhlshhlsssh..hshulshl..shPLhhhhhsss.hs.hh.............hhlsohspuls..hsh...l.Gllhl.hlsha..ls.sslsp....hpuhhs+uLL	.....................................allhshshulhh.hs.hhlsh.lshuh..slsh.hhl.G..lPlL.s.h.slh.ssRs.huphERtp.scthh.......uh.pl.st.s..........tt............................suhhtp..lt.thLp.DssoWRslhahhl...phsluhlshhlslsh.hshs.lh..hl......hh....Plhhhhhs........h......................................h.lsshstshh.hhh....h.Gllhh.hhshhls.tshsthpshhspthL.................................................	0	68	162	199
+13639	PF13797	Post_transc_reg		Post-transcriptional regulator	Eberhardt R	re3	Jackhmmer:D3EKT1	Family	This family includes post-transcriptional regulators [1].	25.00	25.00	30.60	30.50	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.57	0.72	-4.39	26	293	2011-02-11 10:56:17	2011-02-11 10:56:17	1	1	293	0	38	158	1	86.50	35	87.77	CHANGED	phcta+cp.lpPsLpsKh-EF+hLGYcplot-clWsaLhp+KWK+ppt...hpLaEllsDIhslphs-YMsahTlcuhcssshhhsctspc	..........h..p.hppp.LpsslcpKsEEF+hhGYcplsp-DlWpaLpscKWK+tss...lpLaEhlsDlhplpssEaMsYlslpAhpus...hsph-....................	0	15	28	30
+13640	PF13798	PCYCGC		Protein of unknown function with PCYCGC motif	Eberhardt R	re3	Jackhmmer:D3ELL0	Family	This domain contains a PCYCGC motif and four other conserved cysteines. Its function is unknown.	25.00	25.00	30.10	26.80	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.17	0.71	-4.54	13	157	2011-02-11 11:09:16	2011-02-11 11:09:16	1	2	138	0	31	109	15	151.10	54	89.50	CHANGED	hh.hllshullLuGCussssp-pspscp...........pppssGDIpEpTuSs-pLPoFLcs.ps-slpplYptuupppELL-aIPCYCGCGESAGH+sNhsCFlpEp+cDGslVWDDHGT+CGVCLEIAspShphhpcGKShK-IRphIDEpYKEGYAKPTPTPMP	............................lhu..hlsllSllLuGCGususs-..p.....psucp.pppt.......pto+oppuD.IQEcT..KulDsLPoFL-c...h-spM+cIYslAGpssELL-aIPCYCGC..G.E.SsGHKNN+NCFI+EIKKNGc.V.V.WDoHATsCssCLEIAVESuuM+QcG.K.S.shEIRsaIDsKYKEG.YuKPTPTPMP...........	0	9	22	25
+13641	PF13799	DUF4183		Domain of unknown function (DUF4183)	Eberhardt R	re3	Jackhmmer:D3EMB4	Family	This domain of unknown function contains a highly conserved ING motif.	25.00	25.00	25.10	36.50	24.70	22.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.89	0.72	-4.17	22	220	2011-02-11 11:15:06	2011-02-11 11:15:06	1	6	107	0	31	144	6	77.60	40	52.48	CHANGED	sssh+ahaTss-clthhustsIsust...................suYhNLaINGVLQ.tshY.sls...sutLsLpssss..htGsPIllph	.................h.suc+hh.TsusGhuthushsIsussh...................hoYhNLaINGlLQssshh.sVo.......TGslTls........ssss..lssGoPIhlEF..	0	11	21	21
+13642	PF13800	Sigma_reg_N		Sigma factor regulator N-terminal	Coggill P, Eberhardt R	re3	Jackhmmer:O07581	Family	This domain is found near the N-terminus of a sigma factor regulator. The N-terminus is responsible for interaction with the sigma factor [1].	25.00	25.00	25.00	25.70	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.22	0.72	-3.96	22	353	2011-02-11 14:42:16	2011-02-11 14:42:16	1	4	247	0	37	251	0	91.50	25	27.43	CHANGED	.Kphl++uKhKthlp.h.llslhl.hlllhhhhhhhshl.ah.sp....spch.hpshphhhplopPNshlssp.hp.sphs.hFutshph.sl.KplGscsl.	..........h.ct.h++uK+Kphlphh..llslsh.sllllshhh..h.shhha..sp.....phpcl.p-hhshthplst.PNsphsup..ht.sssp.hFusphph.shhKslsshsl..................	0	6	20	28
+13643	PF13801	Metal_resist		Heavy-metal resistance	Eberhardt R	re3	Jackhmmer:A3K6W9	Family	This is a metal-binding protein which is involved in resistance to heavy-metal ions [1,2]. The protein forms a four-helix hooked hairpin, consisting of two long alpha helices each flanked by a shorter alpha helix. It binds a metal ion in a type-2 like centre [3]. It contains two copies of an LTXXQ motif.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.29	0.71	-4.14	97	966	2012-10-02 12:34:46	2011-02-14 13:53:14	1	3	826	26	248	1113	79	123.10	29	76.98	CHANGED	sSLslNlhllGslsusshph.ssttstt................thht.hhtsLsscppctlppthcstt.t...phpshppph.cpttpplhphltApshDssslpsslsptpptptphppthppthlshhsshss...cpRtt	...............................................................................................th.......hhhul..uhuhss.ss.uhspsup.............................shhp..ps..s..s..sL.....T..sEQpst...h...pclhs-ah..s........ps...s...u.L.....p.....p.....p.......l..hscR........hE.h....s....A....LL.s.As.ssDsu..c.lsAlsc-hcslpppLcchp.lcpslshspshhPct...st.....................................	1	81	156	203
+13644	PF13802	Gal_mutarotas_2		Galactose mutarotase-like	Coggill P	pcc	Jackhmmer:Q8FC64	Domain	This family is found N-terminal to glycosyl-hydrolase domains, and appears to be similar to the galactose mutarotase superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.35	0.72	-4.12	218	2671	2012-10-02 23:57:29	2011-02-14 13:55:17	1	55	1668	60	985	2314	64	65.70	31	7.77	CHANGED	sEphYGlGE.+.s.....s.sls....++.....G................pphch...aNt....Ds..hsh.p..ps.......csh.....YpsIPFhlshp.......ss..p.......u.aGlFasNstcshaD	....................EplYGLGE.+..h.....s..sls....+p........G.............................pshch.....aNp...Ds....hs..p...ss....................pth..........YtslPFhh.................ss....p..............u..a....Glahssstps.h...............................	0	358	606	839
+13645	PF13803	DUF4184		Domain of unknown function (DUF4184)	Eberhardt R	re3	Jackhmmer:D3EE91	Family	This domain of unknown function contains several highly conserved histidines.	25.00	25.00	25.20	74.50	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.81	0.70	-5.06	38	172	2012-10-01 21:01:47	2011-02-14 14:10:33	1	1	170	0	22	182	3	235.70	41	94.91	CHANGED	MPFThSHPAhllPlp+hsh....LshsALllGSMsPDh.YF.....hthp.......tsshuHshhGlhhhsLPlslllhhlaphll+psLhphlPh.hp.phhs.hp.....hh.hcph.l....lhlhShllGshTHllWDuFTHpsGa.hVpthshLpppl..thhs..tlPla+lLQauSollGllhlhhhhh+hhpppspp.t..h......ptKhhhhhhlh...lhuhlhhhhhhhhhs..h.....hhhhsphllshlsuhhhulllsshlh	..MPFT.F.uHPAAVLP.hsK...+p...s.pt...lsloALlLGSMAPDFpYF...........lpF+P..........aGslGHsWhGhlahNLPLshLLAhla+hllKcPhlsaLP+sas.shasa.shs...p..tas..htoh..+pa..h.......VF..shSALhGhlTHVlWDuFTH..psGa.FVhplshLpppl.......h.sIPlYKhhQHGSTslGlllLlahla....+atpc..psp.chhhth.......pcKhpaWhslh...lluhll.hhlashl.s.a.h.....hatlGthIVshlsu.hsuhhlsslla.........................................................	0	7	16	21
+13646	PF13804	HERV-K_env_2		Retro-transcribing viruses envelope glycoprotein	Coggill P	pcc	Jackhmmer:P61569	Domain	This family comes from human endogenous retrovirus K envelope glycoproteins.	19.40	19.40	23.30	22.20	18.20	17.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.16	0.71	-4.74	16	352	2011-02-14 16:01:45	2011-02-14 16:01:45	1	5	6	0	22	230	0	167.60	89	44.44	CHANGED	TPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCP	..........................................TPVTWMDNPIEVYVNDSVWVPGPTD.DRCPAKPEEEGMMINIS..IGYRYPPICLGR......APG......CLMPAVQNWLVEVPTVSPISRFTYHMVSGMSLR..PRVNYLQDFS.YQRSLKFRPKGKP.CPKEIPKESKNTEVLVWEECVAN..S..AVILQNNEF.GTIIDWAPRGQFYHNCSGQTQSCP.............................................................................	0	17	17	17
+13647	PF13805	Pil1		Eisosome component PIL1	Coggill P	pcc	Jackhmmer:O74960	Family	In the budding yeast, S. cerevisiae, Pil1 and another cytoplasmic protein, Lsp1, together form large immobile assemblies at the plasma membrane that mark sites for endocytosis, called eisosomes.  Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalise nutrients in all eukaryotic cells.	27.00	27.00	27.10	27.70	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.76	0.70	-5.25	7	285	2012-10-03 12:17:00	2011-02-14 17:38:51	1	8	137	3	215	271	1	249.20	51	65.78	CHANGED	MHRTYSLRsSRsPTASQ..LpsPPPPsSoTKotpaFGpsulu.aohR+ssAGuhGP-LuRKLuQLVKhEKNVhRShElsuRER+-sA+QLShWGE-.................sDDDVSDVTDKLGVLIYElGELEDQaID+YDQYRlTLKSIRNIEuSVQPSRDRKpKITDpIA+LKYK-PpSP+IsVLEQELVRAEAESLVAEAQLSNITREKlKAAasYQFDAh+E+uEKhALIAGYGKtLLELLDDoPVTPGEoRPAYDGY-AS+QIIhDAEsALspWsLDsAuVps	............................................................h.stst......................ttsss.s...S.osp.s........hh..sp..t..uhu....pshR........ht.s.t..G...shs.P..-Lu....+KLspLlKhEKslhcu....hEhsu+ERhpsApQLShWG.ps..........................s.D.-.D.VSDlTDKLGVLlaElGELEDpas-+.aDpYRlolKSIRslEuSVQP.SRDRKp..KI....o....DcI....A....p.L.......K.....Y...K..........-.....P.......p....S....s....K.......l.......sV.......LEQE....L..VRAEAEoL.....VAE.......AQLSNITRp.......KlKsAasapFDAlhE+uEKhAlIAsaGKtLL-L..l..DDoP....VsP......GEoRsAYDG..a-s.o+pIl.DAEsuLpsWp.s.s.h.......................................................	0	56	115	183
+13648	PF13806	Rieske_2		Rieske-like [2Fe-2S] domain	Coggill P	pcc	Jackhmmer:Q8FCX0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.21	0.72	-4.31	77	1917	2012-10-02 12:49:59	2011-02-14 17:40:20	1	23	1666	11	493	2846	625	103.40	36	52.55	CHANGED	sWpslCslcDlhPsoG..VsALl.s..spQVAlF+s......t.s.s.....plaAlsNhDPhupAsVLSRGllGs.h.tGchsVASPLaKQ+FsLpoGpClE...................sss..hsltsaslRlp.sGpV.Vp	....................................................................WhslC.pl--.lh....P.t....sG.....hs.s..l..l.......s......s.......c..p.....l...AlF+s......pss...........pla.AlsNhsPa...c..u.....ul...L.....S.....c......G.l...........l............u................s.....c........t..............t..............p........................h.......V.....ssPL+KQ+Fc...L.....p.....s......G..t..s.h.-........................................s.-.p...hsVpsYss+.Vc..DGtV.l.h...........................................	0	114	271	403
+13649	PF13807	GNVR		G-rich domain on putative tyrosine kinase	Coggill P	pcc	Jackhmmer:Q8FKJ4	Family	This domain is found between two families, Wzz, Pfam:PF02706 and CbiA Pfam:PF01656. There is a highly conserved GNVR sequence motif which characterises this domain. The function is not known.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.62	0.72	-4.23	72	3261	2011-02-15 09:40:19	2011-02-15 09:40:19	1	7	1874	0	746	2626	476	78.50	26	13.58	CHANGED	pTQQclL...RLpRDVcVspplYspLh.sptQp.hpls.p..AuslGNVRIlDs.A.sstsc..PVKPKKsLlllluhllGhhluluhlllRph	..............................................h....plpRphpstp.plYhtLL.p....+..pp....hpls...p....st.ss....u...s...l.....+..l..l..Ds...A..hs..s....t...Plp...P..++.tL.ll.l.l.u.hlLGlhlu.lshsll+..h.........	0	230	467	612
+13650	PF13808	DDE_Tnp_1_assoc		DDE_Tnp_1-associated	Coggill P	pcc	Jackhmmer:Q2EEQ8	Domain	This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, Pfam:PF01609 and its relatives.	30.30	30.30	30.30	30.60	30.20	30.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.74	0.72	-4.32	95	1944	2011-02-15 10:37:59	2011-02-15 10:37:59	1	5	565	0	251	1556	231	80.30	40	30.01	CHANGED	LhpthsplsDsRp.sp.shcasLsslLhlslsAll.uGucuap-Itpaups+...phLpphh..sh..pG.......lPSccThpRVhptlDspthppsatpWhp	...................hphhp.l.D.Rp.th..phcHpLscILhLslsAVI.uGA-uWc-IE-FGcs+h..-aL+pah..sh..cpG.......lPscDTlsRVlu.pl..sstthppthhpah..................................	0	73	179	221
+13651	PF13809	Tubulin_2		Tubulin like	Eberhardt R	re3	Jackhmmer:D3EKE8	Family	Many of the residues conserved in Tubulin, Pfam:PF00091, are also highly conserved in this family.	25.50	25.50	25.80	26.10	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.16	0.70	-5.50	23	225	2012-10-03 12:11:42	2011-02-15 14:23:36	1	7	203	0	66	232	45	326.50	31	31.02	CHANGED	llIGLGGTGt-llt+lR+hIhppatt..................sthshlsFLhlDT-ps...........hstp.....thshcphcchhthhsspsssshhpphp.........sastlpp.......WhPsch.p...........shpslcsGAGplRslGRLAF......hspappIpptlpsthc...............h........hthcstssulslalVuSLuGGTGSGhhlDluYplRphh......ttpsshtlsuhllhPs...hasshsss......sphpANuYAALtELsaasshsscapsphstttspph.spps....................PFDhsYLluspNspsth..hshcplhphlApsIa.LphosthustppshccNhhpphtpssststs..................ahsFGhusIthPh-pItshlth+lspphlpha	...............................................................................................................................llIGLGGhGuplhtpl.hcp...l.c...........................-p.cp.lt..hhshDTshs..............................................slsphcc.hh..p..hh..sp.sssuph..pchh....................spP..pIsc..........Wh.Ph-.ph............spslspG..A..G..QlRsluRLuL..................s+l...ss..hhpplcchhs..................................ssucts.phul..p...VhlVoSLAGGTGSGMFLplAhhLRphl......htpcshh..ltuhhlhP-...lhspspsss.......hcplpANG...YAuL+E.Lcthphs...sstt..hs...tp.tthsh..php...hpss.....................................Pas..hsaLhsh....cNh.c..G...ptl...tshsphhc.h....ApsIh.hthhsshus.tph..stp......c..s...hpphtpsss.p..sp...................asshGhuplhhPh-clhphsAh+huhphlp..........................................................................................................	0	19	47	55
+13652	PF13810	DUF4185		Domain of unknown function (DUF4185)	Eberhardt R	re3	Jackhmmer:D0L2Z5	Family	\N	25.00	25.00	25.00	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.31	0.70	-5.53	52	408	2011-02-15 14:28:20	2011-02-15 14:28:20	1	10	213	0	128	358	13	297.80	29	69.59	CHANGED	TGs..........spTsp+aslsGTDLGIhacsssG....phhhsFGDTFu.........ssssGs.....sWRSNllhhSs.spslsc..Gl.........thsusst..ss.sp.Acpll.s.s.p.......sh-h......ThIPTuuIsls....s..spYlphMol.+sWus.s.....W.TNaoslshSsDsGpoWspsststpsss...........sG.sp.....h..suhsp.......scG..aVYhauT.ssuR..susshLuRV...tsplhsh......s.....uYEaWssss.......W..upss...usPllsus..sGElSlpap...t.hG+WlhhYhs.........s..s.tslshRsAssPpGsWo.stslssshp..................hs.p..LYGuYIaPhS.p..s..ttLaaslSpWs.........sYNVhhh+s	.................................................................................ps.tcaulsuTDLG.h.h-.sss...........pllhhFGDoFu..........sts.Gt.....tWpssshhpsp..spslss..Gl....................phsusss.........thuppll.s.s.............s....th......ohlPousl.sls..........t.......ppYlphhoh.+s.hss......................hotlshSpD.s.GpsWpshstshpsss.......................st.st....t....h.sshhp....................ssG...alYhhu....o....s........s........R.......s........s.........sshLsRs..s..p.plh..Dh.................s.....papaWsuss.t...................W.....s...pss.....hoPl..h..s......ss.................lG.Eh.Slph.............spalhhYhs.........s...st.....ss...lhhRs...A..s...pPpu..sWu.stslssshp................................hs.t...hYusalpPhS.....h....s...........p.LhhhlS.Ws............sYpVh.hp....................................................................................................................	0	40	89	115
+13653	PF13811	DUF4186		Domain of unknown function (DUF4186)	Eberhardt R	re3	Jackhmmer:D0L5G5	Family	\N	25.00	25.00	40.50	40.40	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.54	0.71	-4.37	43	607	2011-02-15 14:30:59	2011-02-15 14:30:59	1	3	591	0	60	245	5	107.10	72	88.23	CHANGED	ph-plFpRLu+SsFRuRF...+Lstc-psYlpcKGhssIppHApDFlscRLAPAhPsNDGKQTPMR....GHPVFlAQHATATCCRGCLpKWHtIstG+sLotpEQpYlVsVlhpWlpp	.....sh.-sLFARLuRSpFRSRF...RLGhKERQYCh-KGAsVI-pHAADFlA+RLAPAhPANDGKQTPMR....G..HPVFIAQHATATCCRGCLAKWHsIPQGhsLSEpQQcYIVuVIa+WL..Vl............	0	14	31	43
+13654	PF13812	PPR_3		Pentatricopeptide repeat domain	Coggill P	pcc	Jackhmmer:Q9USP3	Repeat	This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. The exact function is not known.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.43	0.74	-7.99	0.74	-3.22	132	5769	2012-10-11 20:01:04	2011-02-15 14:46:39	1	1960	345	0	4254	55882	730	33.00	18	6.79	CHANGED	htsassllpshs..c.tup...hpt....s...hplhpp.Mp.p.p...u......lpP	......................tasslls.s.hu......+..sGp............hcp....................A..........hplhpp..Mt.t.t....t........................................	0	932	2789	3676
+13655	PF13813	MBOAT_2		Membrane bound O-acyl transferase family	Coggill P	pcc	Jackhmmer:O74380	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.18	0.72	-3.91	101	505	2012-10-01 20:09:06	2011-02-16 11:45:15	1	13	129	0	397	1144	83	88.40	25	20.91	CHANGED	aP.s.lFGs...h....hpA.....h...o.....lpp.....FWGc.hW..HQhhRt....hhps....h....u....phl....h+t.lht........p..........ht+hhplh...hsFhlSGllHhhsshhhst............pt.....shh....FFhh	...............................PhF.sp.....htu.....p...S.....LpcFWG+..t............W..Hphhpp..................hhps........s....u....hh.......spt.hht...............pt.......................htphstlhssFhlSGl.hHths...hhhsht...........sh.........hh.FFh.h..........................................	0	152	254	343
+13656	PF13814	Replic_Relax		Replication-relaxation	Eberhardt R	re3	Jackhmmer:D0L6G0	Family	This family includes proteins which are essential for plasmid replication [1] and plasmid DNA relaxation [2].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.29	0.71	-4.45	47	432	2012-10-04 14:01:12	2011-02-16 13:12:31	1	3	244	0	81	370	8	165.50	19	62.86	CHANGED	Lthl..tcHphLoscQltplhhsstt.........tspppLpcL.pphphl.cphp.................ts.uptshhYhLsttG......tchl............st.ts.........t......tt............pttt...hsss......t.pls.HplslschastLh.tts.+pt...s..hp..ltcWh.....sE.psttt..h.............t..p..h.lpPDuhhthptss.......tthtaalEhDpuTEshtp......ltpKlppYtc.hhptt............tt..........s.hPl....l	.................................................................l..hthhshpplhthh...t.h...........sspphLpc.L...p..t......hl.pphhh..........................ttt...hhahL.sppG...hphh..................tt........................................t..hhss...t.plt...HpLhhs-hh..lphh..p.s.....t......................tap..............hEtphthp..h...........................tttt...t..h.lhPDshhhhppp....................hh....lElDpspps.hph.........htcKl.ppYtc.hhp...........................................................................................	0	34	66	73
+13657	PF13815	Dzip-like_N		Iguana/Dzip1-like DAZ-interacting protein N-terminal	Wood V, Coggill P	pcc	Wood V	Family	The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.	26.20	26.20	26.40	26.40	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.20	0.71	-4.29	16	230	2011-02-16 13:19:29	2011-02-16 13:19:29	1	6	105	0	130	203	1	116.60	34	17.34	CHANGED	FpFpsRp-plDWR+luulDl-+l...s+-hDlsTLQcsl.sIoFsclpsEcssp.....s-shhLKLa+LuQLsIEYLlasQ-hLssp...spL--+lpps.pttcptcpphs+ppc-hphl.KcEs+	........FpFp..R..p.cslDWR+luulDl.D+l...spchDltsLQ-plt...s.lTF.CsL-sEcssp..........lDPsl.lKL.hRLAQLsIEYLLH..sQ-......hLssp.........lppLcccLptu.tptpphcppltcpsp-l+tl.+cE.+...........................................	0	52	68	93
+13658	PF13816	Dehydratase_hem		Haem-containing dehydratase	Eberhardt R	re3	Jackhmmer:Q76K71	Family	This family includes aldoxime dehydratase, EC:4.99.1.5. This is a haem-containing enzyme, which catalyses the dehydration of aldoximes to their corresponding nitrile [1]. It also includes phenylacetaldoxime dehydratase, EC:4.99.1.7. This haem-containing enzyme catalyses the dehydration of Z-phenylacetaldoxime to phenylacetonitrile [2]. The enzyme forms an elliptic beta barrel, composed of eight beta-strands, flanked by alpha-helices [3].	25.00	25.00	25.90	25.40	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.94	0.70	-5.38	33	119	2012-10-02 00:20:33	2011-02-16 13:30:49	1	4	97	20	74	142	8	286.30	33	82.63	CHANGED	hAhhGlQhpus.st.........stAhssltphlpt..hssssuPpth.-hsthsDssGhpshlhluYWp-sssacpWhpssshssaWsuhs...tpshGhapElhsssscRaETlaSsp-hh.Gluplhs.shos.hpcHuYWGuhRDRhPhopsDthts.........sspsth.sssstttGRlhls..sh.-NlshIRSGQDWussss-E+chYh-pl-PsLppGMcaLp-putcsGChosRahpshDs....c.ss............h.hccohsluaacsLssLE+Wu+oH.THlsIassFhchs.pshs....thcLRLaHEVuVLcsspthFEYlsCHssTGh	....................................................huhhGlQhpssst..................ssAhpsltphhtt....hstssuPsta.-hsph.sDspGhtshlhluYWps....ssappWhpssshssaWpu.s...t.pps.....hGaapElhssps-RaETlaut.ch.h.Glutlhs.shos.hpcpuYWGuhRDRh.Phops.D.hhts.....................ssp.th..s.sssttsuRlhlt..sh.cNlshIRSGQDWussps.cERphYh-plcPsLppGMsaLcDpGtpsGChusRahpslD...........c.tp...............h.hccohsluaapsLspLE+Wucs.Hs.THlpIFssFhchs.pths.....hpLRLaHEVsVhcstpthaEYlsC+stTGh................	0	10	29	59
+13659	PF13817	DDE_Tnp_IS66_C		IS66 C-terminal element	Coggill P	pcc	Jackhmmer:P39351	Family	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-7.80	0.72	-3.94	114	3268	2011-02-16 13:47:29	2011-02-16 13:47:29	1	17	854	0	386	2560	227	38.70	51	11.84	CHANGED	SLIpTAKLNGl-PpAaLp-VLsR.I.ss..a.st.sRlc-LLPWs	.......SLIuTC+LNsl-P.EuYLRa...VLsh.l..s-.....W...Ps....N......R....Vs-LLPWp............	0	81	201	298
+13662	PF13820	Nucleic_acid_bd		Putative nucleic acid-binding region	Coggill P	pcc	Jackhmmer:Q14686	Family	This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.	21.60	21.60	23.20	21.60	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.64	0.71	-4.61	6	169	2011-02-17 13:43:59	2011-02-17 13:43:59	1	25	69	0	126	158	0	143.50	40	12.42	CHANGED	hSNlaVsspGplc..hhptpLDpL+ppLspLhuscpSplhh+chcha+SlhVcFoIPREssssLRphA-puD.cLhhhGIpS....lQI-u-ssI.slsppushaD..st+p..ssslc.lGsSsRscttps......tShstL.u.sl.ucshsspstsh...ussph	................SslaVsh+Gslc...hp.pLDplhps.lssL.h.p.h...c...........p.Sp............l.Khpthc.apSlhVpFsIPREssthLRhhAppss.pLh.hGlhS......lQI..-uEs...sI.plt.utsh.pshR.........sssht.sGsSs.Rhctths...........tuhstL.th.s..ussh..thtssuS..h.................................................	0	82	87	106
+13663	PF13821	DUF4187		Domain of unknown function (DUF4187)	Coggill P	pcc	Jackhmmer:C6Y4A5	Domain	This family is found at the very C-terminus of proteins that carry a G-patch domain, Pfam:PF01585.  The domain is short and cysteine-rich.	27.00	27.00	27.10	29.60	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.22	0.72	-4.37	53	314	2011-02-17 15:57:08	2011-02-17 15:57:08	1	13	227	0	230	315	0	67.60	35	14.86	CHANGED	--E...............hc-.ptLsspEcLppLlpYLRpcapYCaaCuhpYcspc-l...psCPGss.................................E-DH	...........................pE...sc.-tLssp-+LphllpYLRcpapYCaaCshcY-stc-L...cpCPGss....ptpH.....................................................................	0	65	115	181
+13664	PF13822	ACC_epsilon		Acyl-CoA carboxylase epsilon subunit	Eberhardt R	re3	Jackhmmer:D0L8S8	Family	This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes [1].	25.00	25.00	25.20	25.70	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.16	0.72	-3.62	83	404	2011-02-17 16:15:50	2011-02-17 16:15:50	1	1	355	0	109	286	9	60.60	33	71.49	CHANGED	pshl+Vl+GsPosEElAALsAVLsuh..uusssssssss..........stWuc.sc......htt..hsuPsuW	.......shlpVl+GsPTsEELAALlAVluuh.........uusussstssst...............stWsp.hc......htcshh.u.tua..........................	0	30	81	105
+13665	PF13823	ADH_N_assoc		Alcohol dehydrogenase GroES-associated	Eberhardt R	re3	Jackhmmer:D3EFL6	Domain	This short domain is frequently found at the N-terminus of the alcohol dehydrogenase GroES-like domain, Pfam: PF08240.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.24	0.72	-6.44	0.72	-4.28	120	1545	2011-02-17 16:20:05	2011-02-17 16:20:05	1	5	1130	2	440	1190	19	22.70	51	5.97	CHANGED	MKAlsapGt+cVcV-pVPDPcIp	.MKAlsa+GsccVcV-s.VPDPtIp...	0	117	274	373
+13666	PF13824	zf-Mss51		Zinc-finger of mitochondrial splicing suppressor 51	Coggill P	pcc	Jackhmmer:Q9UTB4	Domain	Mss51 regulates the expression of cytochrome oxidase, so this domain is probably DNA-binding.	27.00	27.00	28.00	28.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.04	0.72	-4.11	25	148	2012-10-03 05:12:49	2011-02-17 17:23:16	1	5	144	0	111	149	0	63.70	44	12.10	CHANGED	hCPhss......+............................clpapCPcCGlPsaCScEHWccD.EtHtc..hCpsLRp.lNE.s-HDL	.................hCPhss...+p..................................tclpapCPcCGlPsaCScEHWtcDhEtHhp.lC-tLRp.lNc.D-HDL......	0	26	56	93
+13667	PF13825	Paramyxo_PNT		Paramyxovirus structural protein V/P N-terminus	Coggill P	pcc	Karlin D	Family	This family consists of several Paramyxoviridae structural protein P and V sequences [1]. From a structural point of view, P is the best-characterised protein of the replicative complex. P is organised into two moieties that are functionally and structurally distinct: a C-terminal moiety (PCT) and an N-terminal moiety (PNT). PCT is the most conserved in sequence and contains all regions required for virus transcription, whereas PNT, which is poorly conserved, provides several additional functions required for replication [2]. P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional. The N, P, and L proteins of SeV and measles and mumps viruses are functionally equivalent. However, sequence identity between proteins from these viruses is limited, and the viruses have been placed in different genera (Respirovirus, Morbilivirus, and Rubulavirus, respectively).  SeV P protein (568 aa) is a modular protein with distinct functional domains. The N-terminal part of P (PNT) is a chaperone for N and prevents it from binding to non-viral RNA in the infected cell [3].	21.70	21.70	22.20	21.70	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.67	0.70	-5.21	8	536	2011-02-17 17:37:57	2011-02-17 17:37:57	1	6	59	0	1	461	0	228.70	56	64.32	CHANGED	EQAYHVsKGLECIKALRtsPPDh.pIcEs.uhhscsssssspsssTscpEEtDoQslscSCpPAhGSspsutshtcspGsGE..sNssssEhttsPc-.tpsusulpCYaVYDHSGEcVKGIEDADSLlV.uGssusssFpGG-suS--SDsDSGEsDoEGsAsoshGSust.pssRAoDVEplpu-ElptLLRoQppsssth+sGKTLpVPssP-sppussSspPIKKGT-cRSsSaGTthsuu.TuGATQsAhKSsuuSStPuASAGNVhpssoNAchhQcsp.ESGTphSP+opNptES-sEYDDELF	.....................................................................EQAhHVppGLECl+AL+tpP.s..tlpEs.uhhsphpssstpptsssh.ppctsspslscsp.sAhGSs..sutsh.ps.GstE..usss..pht.ssts..tsusGlppYaVYD.HSGEtVKGIpDAD...SlhV.uGhsusps..hpsG-sp...-sSs.D.GEs.oEG.A.oshG.u.h.hs.RAuDVphh.ttElptLLRhpppss.h.+.GKTLphP..sP-st..pussppssIKK.G..TctR...ASaGht.Isuh.h............................................................................................	1	1	1	1
+13668	PF13826	DUF4188		Domain of unknown function (DUF4188)	Eberhardt R	re3	Jackhmmer:D0L3R6	Family	\N	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.77	0.71	-4.00	48	173	2012-10-02 00:20:33	2011-02-18 08:00:56	1	3	167	0	98	217	26	116.20	33	56.30	CHANGED	lVVFllGMRlN+hhul.....ppWhslhtAMstMlcE.Ltps.....-.hGhLut.cs.ah.h......csshllQY.WRuhEsLcsaA+..sp.HhtAWcpFsppst.s...s.ssVGIaHETYhl.tGpaEsIYsNM.P.shGL	............................................lVVFhlGhRhN+.huh......tah.lhtuhstMlc-.Ltpst.........chGhLuhp.hh.s............psh.hhlpY.WRuh-sLppaA+..st.Hh..pAWch...aspthps......sspVGIaHETYhl.tGpaEsI.YsNh.P.shGL...............	0	21	61	84
+13669	PF13827	DUF4189		Domain of unknown function (DUF4189)	Eberhardt R	re3	Jackhmmer:D0L9M9	Family	This domain of unknown function contains six well-conserved cysteine residues.	25.00	25.00	25.20	25.50	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.15	0.72	-10.90	0.72	-3.75	66	395	2011-02-18 08:10:12	2011-02-18 08:10:12	1	7	227	0	89	316	4	96.50	27	61.71	CHANGED	paGAlAh..ssssGs....hGhuhshs.ocppAcptAlppCpt..........t.tsCclhshapNt.CuA..lAhstpstt........thususshp....pApppAlppCtptss...........pCplhh.tsCo	................aGAlAh..sss.us.....hGt.uhs..ts..optpApttAl..p..pCtt.............psC+llsphps........CsA..lA..hststh.................tsususshp....sAcpsAlspstt..............tstl.s.hsCs..........................	0	14	46	68
+13670	PF13828	DUF4190		Domain of unknown function (DUF4190)	Eberhardt R	re3	Jackhmmer:D0LA47	Domain	This integral membrane domain is functionally uncharacterised. One of the membrane helices contains two GXXG motifs that are usually associated with dimerisation.	35.00	35.00	35.10	35.00	34.90	34.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.00	0.72	-4.42	107	528	2011-02-18 08:18:59	2011-02-18 08:18:59	1	16	318	0	182	498	26	63.40	31	30.28	CHANGED	hAIuSLVh.ulhuhhh..........lsullullhGalAhspI+css..ppGcGhAlAGlllGhlslsl...hllh	.........hAluuLVh.ulluhhh..........h..lhullullhGhlAhspI++ss.....ppGcGhAlAGlllGhlslllhll.h..............	0	59	137	166
+13671	PF13829	DUF4191		Domain of unknown function (DUF4191)	Eberhardt R	re3	Jackhmmer:D0LAZ2	Family	\N	25.00	25.00	133.10	129.00	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.32	0.70	-5.23	55	434	2011-02-18 08:42:45	2011-02-18 08:42:45	1	1	433	0	112	285	112	229.20	39	91.39	CHANGED	s++s.cpp.....pphpQlhpuaphpR+pDspl.l.hhluuhluslslhlllGllhs..th...hhhlllGlh....lGlLsAhhlFuRRsp+usYsplEGQPGAAussL.p.slRt....sWplss.sVAss.....+p..D.....hVHRllG+PGllLVuEGsssRl+sLlspE+K+lsRlls..ssPl..aslhlGsu..EGQVPLpKLp+plhKL..P+s...lsps-lsslspRLpALs.....ssthsl...PKGPhPppA+.t+sshR	........s..csppttphpQlhpsFphpR+pD.pLl.hhlGu.Flssl.sl.hhllG.llhs.....th....ahhlllGlh....lGsLsAhhlFsRRAp+usYs+hEGQsGAAuhALs.slcp.......tWpsos.uVAhT......+p.D........sVHRslGhsGllLlGEGs.ssRl+sLLupE+KRhtRlss..slPl..acIllGs.G.......-G....QVPLcKLc+pltKLP+.s....................lossplsslssRLcALs....htsssslPKGPhPp..s.h.Kh.spsh...........	0	34	82	104
+13672	PF13830	DUF4192		Domain of unknown function (DUF4192)	Eberhardt R	re3	Jackhmmer:D0LBR8	Family	\N	25.40	25.40	26.00	26.10	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.13	0.70	-4.78	56	428	2011-02-18 08:58:27	2011-02-18 08:58:27	1	2	346	0	131	346	78	282.00	26	82.83	CHANGED	Pu-llAAlPtlLGFhPpc.SlVllsl..................sph.GsshRhDLs.......hst.sptlst.hh...........s...t.....tpscsslsllhss..t.t.s............thpthhptLtpthsst.slsl..hsshhh.plssGphWphh...............s......ssGt..shssssossssA.slhs.Gphs.hssRs-ltAtlt.....s.s.h.tstthstshpttsht.t.ph.......t............th..t..h..chhttsspphspu.............phhsss.....tphutluhsLs-spl.RDthhshsst...csussA.tpLWttluRphsus...h...RusslsLhuhsAaspG-ushAshALstAl.....ps-Ps.ashApLLppALppGlpPc	.......................................t-llsslPhlLGFhPpc.SlVhlsh.......................ts...ssth..Gh..VhRhD.Ls........t.ssthsthAt...h.................h.........sssstslslhhsp.....p.tts............................ht.hhts..Lt....psltth..shs..l..hsuh...tl.ssGthWpsh.......................tsss........pts......hc.sssshhsA.ulh...p.G.ht.l...hssRssl.s.hls..................st...t.....tp.sss.htthsttt..th.t......................................tsh..phhhtshshh..tsu..................................pplss........tthsplu....s.ulpcspl.RDhlht.hh.t....................tpAs...t....s..pl......Wttlschh.ss..h.................tstsLsLhuhsuahpG-GshAulslptuh.....thtss.a.....phsthLpphlpsGl.Pt...............................................................................................................	0	42	92	123
+13673	PF13831	PHD_2		PHD-finger	Coggill P	pcc	Jackhmmer:P55198	Family	PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2].  Several PHD fingers have been identified as binding modules of methylated histone H3 [3].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.41	0.72	-4.63	28	1358	2012-10-03 17:27:21	2011-02-21 11:26:41	1	92	289	2	819	1377	16	35.50	47	3.52	CHANGED	ss.llsCs..pCslpVHtsCYGlsp.sst.....WhCs+Ct	...t.N.llaCD...tCslsVHQ..pC....Y.G...lsh...l...P.p...G..p.........WlC+pC.....	0	223	368	595
+13674	PF13832	zf-HC5HC2H_2		PHD-zinc-finger like domain	Coggill P	pcc	Jackhmmer:P55198	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.48	0.72	-11.31	0.72	-4.06	34	1557	2012-10-03 17:27:21	2011-02-21 11:45:05	1	99	292	0	942	2258	15	113.10	38	10.90	CHANGED	scCsLCshcGGAl.KpTs..-.sp..WsHVhCAlh.lPElpFs...sst...phpPl-.lppls.p..R..hchpChhCcpp.........tGACIQCspsp...CtssFHsoCAptAGlhMchc........sh...................h.hhshCt+H	........................................................s.pChLC.......P.......p.......c.......s.........G.......A.......h.........K.......p........T....s...........s.....s.....+............W......s..HVsCAla.....lP....E.V...p.Fu..............ss.t.......................p.hE......P...ls......l.............p.p.IP......s..........R.........a.p..L.......pC.hlC+pp........................sGA.Cl.Q.........Csptp.........C..h.........suFHVTC.A.p.p.u...G.lh..hch.p.....s.t...................th.hhsaC.hH.......................................................................	0	261	429	688
+13675	PF13833	EF-hand_8	EF_hand_6;	EF-hand domain pair	Coggill P	pcc	Jackhmmer:B4DPI1	Domain	\N	27.00	13.80	27.00	13.80	26.90	13.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.45	0.72	-4.35	49	8724	2012-10-02 16:17:27	2011-02-21 13:12:04	1	472	1753	448	3941	29164	1599	50.10	27	16.73	CHANGED	ppGhIoh-sLpcsh.thh..shp.....hscp-.lpshhpthDhDsDGtlshpEFhshhhch	........................................................pG.Istp-Ltphh....pth.........G.p..................................ho..p...p...-...l.....p....p....h....l....p....p........h....D..t.....D....s......s...G..p...l....s..a..p..EFhthh...t..........................	0	1329	2024	2921
+13676	PF13834	DUF4193		Domain of unknown function (DUF4193)	Eberhardt R	re3	Jackhmmer:D0LBT3	Family	This domain of unknown function contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.	25.00	25.00	25.70	27.20	23.30	17.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.46	0.72	-3.83	55	502	2011-02-21 13:14:06	2011-02-21 13:14:06	1	1	430	0	156	293	158	97.70	59	97.30	CHANGED	MATDYDAPR+s-.D-lspDSLEEL.KucRs-p.touslD.DEs-sAEuFELPGADLSsEELoVcVlP+QsDEFTCuSCFLV+HRSQLAc.Ecs...GphlCpDCA	...........MATDYDAPR+o-...D-lsE.DSLEEL.Kup..Rs-p.tSusVDsDEsEsAE.sFELPGADLS...sE.ELoVRVlP+QuDEFTCoSCFLV+HRSpLAp...Ecs...GphlCpDCA....	0	49	105	144
+13677	PF13835	DUF4194		Domain of unknown function (DUF4194)	Eberhardt R	re3	Jackhmmer:D0LDY0	Family	\N	25.00	25.00	25.00	25.00	24.60	23.60	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.73	0.71	-4.81	69	425	2011-02-21 13:18:36	2011-02-21 13:18:36	1	1	392	0	144	392	34	162.10	19	70.16	CHANGED	llpLLcsshlpsppp....plWptllcp...pstlcshLsslhLcLllDcstGhAahcph..p.tp.ts.........pLlpR.p..sLoh.pollLlhLRpphtctp...t.ts.spchllsp--lh-tlps...ahs.tssscsphtcclcsslp+lt.chuhlcphcs......-sp.......aclpsllcshlss-hls	.....................................tLhpt.hlptpp.......phaphlhcp...pstlcshlsslslcLll....Dcp..tshhalpst...........t.t..................hhpp..p..pLshhpollLlhLRphhp-t.....sh.s..stp..shl..sh-Elhphlps...ahs...pscsthtpcl.cp.sl.pchp.phshlpthcs.........t.csp......htlpPhlthhhssp.l.t.................................	0	48	96	127
+13678	PF13836	DUF4195		Domain of unknown function (DUF4195)	Coggill P	pcc	Jackhmmer:Q8ND82	Domain	This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.	27.00	27.00	29.50	31.50	24.50	19.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.20	0.71	-4.58	4	132	2011-02-21 13:42:38	2011-02-21 13:42:38	1	4	32	0	55	149	0	164.30	43	25.84	CHANGED	IFVGEISSSKPAISNILNRssPSSpS+GlKNGshs.GIoshFKPTSQ+hpNPsSNPVsA.P.sFHPtS+SS-SSVhVQshSKPsaspNSspVsSssSS.LLFD.TQDo.Lsp.QshPslshsGhspoSal.K+PSTScVNSVNPKKPKsSEslSthssSoslsS.pSPSVsSSQshLSpGsNoSSs	...............IFVG.hSsSK..PslS..NIL.NRssP.uS.S+thKpsthpp..shsthhpPsSpchhsPoSps..Vss.P.....s.psESRSocSsl.h.l...pshSK..P..sahpsSsQVss.ssSSpLh.sh.sp..p.o..ls..pss.s...s...lshsGhscosh.lSKR.sSTS-l.N..SlNPK+PKhS-ulsthsuSush.sS..spS.ohsopQsh.upsssoS..........................................	0	4	5	9
+13679	PF13837	Myb_DNA-bind_4		Myb/SANT-like DNA-binding domain	Coggill P	pcc	Jackhmmer:Q6P1R3	Domain	This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular Pfam:PF10545 seems most related.  This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.19	0.72	-3.85	185	1844	2012-10-04 14:01:12	2011-02-21 14:15:41	1	81	168	2	1133	1879	0	91.10	22	25.60	CHANGED	pspWscpEsptLl.plh...sp....hc....hpt............pt+st.lWcplupp....h.......t...p.....p.....G.....h...p....R.osp...QC+pKacsLp+pY+pt..+p......t.t....t..tp.s.....p....s....h...a...............................Fcpl-pl	........................................................t..pWs.t.p.EsttLl.phh.......pp....hcttht...................................sst+s.p..hac..tlupt....h.......................t...c.....p........................G..........h.....t.....R.osp...Q.C+pKa.cs.Lp+pY+..+h..+p............t.t........tts............p.....s....h...a................................apphct..............................................................	0	211	533	829
+13680	PF13838	Clathrin_H_link		Clathrin-H-link	Coggill P	pcc	Jackhmmer:Q8NHS4	Domain	This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain Pfam:PF09268.	27.00	27.00	27.40	27.20	26.50	25.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.10	0.72	-4.08	51	782	2011-02-21 14:58:18	2011-02-21 14:58:18	1	37	456	9	307	484	4	59.40	63	6.54	CHANGED	sLsGA-sLahppFppLhspGpYpcAA+lAAsoPpGhLRTspTIp+Fp..phPstP.Gp.s.PlLQYFuhL	.......................sLsGAE-L..FsRKFNsLFAQGsYuEAAKVAAsAPKGl.LRTspTIp+Fp.....slPsp.s.GQsS.PLLQYFGhL..........................	0	99	161	238
+13681	PF13839	PC-Esterase		GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p	Anantharaman V	pcc	Manual	Family	The PC-Esterase family [1] is comprised of Cas1p, the Homo sapiens  C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing  resistance/coldacclimatization proteins typified by Arabidopsis  thaliana ESKIMO1 [2][3], animal FAM55D proteins, and animal FAM113   proteins. The PC-Esterase family has features that are both similar  and different from the canonical GDSL/SGNH superfamily [1]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [1][3]. The Cas1p protein has a Cas1_AcylT domain, in  addition, with the opposing acyltransferase activity [1]. The C7orf58  family has a ATP-Grasp domain fused to the PC-Esterase and is the  first identified secreted tubulin-tyrosine ligase like enzyme in   eukaryotes [1]. The plant family with PMR5, ESK1, TBL3 etc have a\	    N-terminal C rich potential sugar binding domain followed by the  PC-Esterase domain [1].	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-12.05	0.70	-4.58	109	1574	2012-10-02 11:02:24	2011-02-21 15:50:55	1	22	161	0	1001	1544	2	250.40	20	56.82	CHANGED	LPRFsupphLchhR.............sKplhFlGDSlsRspapSLlChLppshs.............................sppphhptps........t.hhaphpcassolpahhsPaLVp..p..............hlcl-plp.pts.ptht............ssDlllhNo.spWWhpp.thh..hs.h.............tpp.hpchshhtuactulpohtpalptslsstp............................................................opVhFpoh..oPsHhcsstWtt........u.tp.C.tp.............ts.thpsts.phhchltcshp.........th.psslphlsl.TthsphRp.......DuHsuhYtt.......................................pDChHWCLPGl.DoWN-lLhshlht	.................................................................................................................................sphsstphLph.hp..............sKplhFlGDSlsRs...apSl..lC..h..Lppsh........................................................ttt.......tt...........................t.hhhth...t..p.a..s...ho....l.p.a.h...hssaLsp........................................................................hhhcpht....ths..p.tht...............shD.ll.l.h.so.....stWahp..th.................................................................t.....phs.h.ht.u.aphslps..h....hphl...t.t..ph....tt...............................................................sp..l.hh..psh...sPsH....h.p.....st.......h.t..........st...C............................................t....th..t.....h.h..ph.h..p.hht.....................hth.hphl.sl...T....hhsthR........DuH.s..a................................................tDC.HWCls..G..h.DsasplLhthh..h.......................................................................................................................................................................................................................	0	251	600	806
+13682	PF13840	ACT_7		ACT domain 	Coggill P	pcc	Jackhmmer:Q8NAP1	Domain	The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements [1]. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.73	0.72	-4.45	192	6068	2012-10-02 00:29:19	2011-02-21 15:51:45	1	38	4053	48	1523	4779	2087	65.50	33	16.45	CHANGED	phppshttlplhGs.......hshthsGlhAplsssL.......uptsIslhhlS...oaposalLVppcchppAlpsLcp	.....................ppsluhlSlVGs......GM+s....hsG.luA+hFpAL..........ucs.sI......sI.h...hIo..oSEhsIShl.l..sp.cphppAl+sLp........................	0	466	918	1239
+13683	PF13841	Defensin_beta_2		Beta defensin	Coggill P	pcc	Jackhmmer:Q4QY38	Family	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.01	0.72	-3.59	114	633	2012-10-01 20:50:19	2011-02-21 16:25:20	1	2	61	0	227	564	0	30.50	36	38.63	CHANGED	cChpt..tGpCRp.pCppsEhhhth....C..tstphC.C	...pChpt..pGpCRp.pCppsEhhhth....C..tssphC.C......	0	33	34	39
+13684	PF13842	Tnp_zf-ribbon_2		DDE_Tnp_1-like zinc-ribbon	Coggill P	pcc	Jackhmmer:Q96DM1	Domain	This zinc-ribbon domain is frequently found at the C-terminal of proteins derived from transposable elements.	17.60	17.60	17.60	17.60	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.38	0.72	-3.54	30	124	2012-10-03 10:42:43	2011-02-21 17:07:58	1	6	55	0	68	155	29	35.10	32	6.86	CHANGED	ppCthCtp......pt.tp........opatCppC...s.....hsLChp........C	........................ppCphCtp......pthtp........opahCppC..s.......ssLChp...........C................	0	25	31	62
+13685	PF13843	DDE_Tnp_1_7		Transposase IS4	Coggill P	pcc	Jackhmmer:Q96DM1	Domain	\N	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.02	0.70	-5.40	48	1008	2012-10-03 01:22:09	2011-02-21 17:19:41	1	50	126	0	857	1024	6	208.80	14	54.68	CHANGED	sPhphFphhhsc..cllppllppTNtthpph.................t.thpssshpElcsFlGlhllhGhh+..hsp....l..p-aWsss...hhu....hshhpssMohpRFptlhpsL+hs-...........s.t...s........tt...Dphtcl+.Llcthspph..pphYsPupplslDEsh.l....ha+.u+hshcphhs.sK.hphGh.chahhs-spouYhhph.....lhp....sp.ssth..t.................p.s......sspllhcLhp.sht.s.ps...+plhhDs..aasSls.LhppLhpp..shhusGslcps+t....thP.....psl..p.........pp...........h...pp...Gphhhths.......ss...l.hhhpapc..scplh.hloo...hps........psh...lptppps...t.........pp.....h...t..pPthlptYspphsu..V-...ptcphht...p.apsst...ps.ppWhppl.hhallshulhNAa	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	377	459	779
+13686	PF13844	Glyco_transf_41		Glycosyl transferase family 41	Eberhardt R	re3	Jackhmmer:O15294	Family	This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues [1,2]. In addition to its function as an O-GlcNAc transferase, human OGT, Swiss:O15294, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1 [3].	25.00	25.00	25.20	25.00	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.61	0.70	-6.52	5	1950	2012-10-03 16:42:30	2011-02-22 08:01:16	1	478	581	32	949	2116	1664	192.00	16	40.67	CHANGED	LRIGYVSSDFGNHPTSHLMQSIPGMHNR-+VEVFCYALSPDDGTNFRsKlMsESEHFVDLSQIsCNGKAADRIHsDGIHILlNMNGYTKGARNEIFALRPAPIQVMWLGYPGTSGAsFMDYIITDuVTSPlELA-pYSEKLAYMPHTFFIGDHAQMFsHLoERVlVctKssu.c.hDsc..tVlNus-.LcPlL-p.psKchV+-spscuGsclDhs+ocVsLPVl.hsT.sEPlcpMIsoGQIsssl.NGVsVQNGLuT.oQsNsKAATGEEVPpoIlVTTRuQYGLPDDAIVYCNFNQLYKIDPsTLsMWscILK+VPNSVLWLLRFPAsGEsNIppastchGlsssRIVFSNVAAKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWTGTPMVTMPtETLASRVAoSQLsuLGVPELIAKsRpEYpDIAlKLGTDtEYL+pIRAKVWpARsoSTLFNsKQYCp-LEcLahKMW	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	267	562	790
+13687	PF13845	Septum_form		Septum formation	Eberhardt R	re3	Jackhmmer:D0LB95	Family	This domain is found in a protein which is predicted to play a role in septum formation during cell division [1].	25.00	25.00	25.20	25.40	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.95	0.71	-11.74	0.71	-4.80	89	373	2011-02-22 08:02:50	2011-02-22 08:02:50	1	6	246	0	129	352	62	180.70	24	53.38	CHANGED	psGsChsh.......................................................................................................................shsupstshs.......................................sVsCspsHssElh.ushslsss............P....utsshsstspctCs.pthpsYsu...st.h....ssslphhahhPoppSWpsG.sR.plsCh	..............................................................s............................................................................................................................................hpststt.s.ts...h.h.h.....sGsClshssss................hstsVsCspsHshEls.usls.....Lssphst..........P.upsp.sshhpstCs.ptsp.sY.lu..........s.th......ssslphhahs.ots.SWs.s.G.sRtVsC...................	0	33	98	123
+13688	PF13846	DUF4196		Domain of unknown function (DUF4196)	Wood V, Coggill P	pcc	Pfam-B_104093 (release 24.0)	Domain	This is a short region of ccdc82_homologues that is conserved from Schizo. pombe up to humans.  The function is not known.	25.00	25.00	25.70	25.70	19.90	18.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.68	0.71	-3.78	4	51	2011-02-22 13:26:22	2011-02-22 13:26:22	1	5	30	0	23	52	0	98.80	59	24.33	CHANGED	KcLhNosNSSshEEphscoKHp..DLsDpEKt.GQp-schNK+TGQIlE.ED.E.....-E.lp.s++p+lSS..lh.DSDppcpSD.h.+psu.....hK+.R+Vlps..SS.-.EppsPEc..pshhR+	..............................cpLhNousuSshEEEhNc.ccp..DL.Dp.EKHh.SQE-sDLNKpTGQIIE..-DlE.....EEpIKpGKRKRlSS..VMhDSD-SD..DSDILVRKVu.....lKRPRRVVEDE.sSSlEME..pcsP..EK..o.AAR............	0	3	3	7
+13689	PF13847	Methyltransf_31		Methyltransferase domain	Coggill P	pcc	manual	Domain	This family appears to be have methyltransferase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.08	0.71	-4.62	66	11527	2012-10-10 17:06:42	2011-02-22 13:32:39	1	237	4093	66	3510	72499	23508	157.30	17	50.53	CHANGED	hppshplLD.....lGCGsGhhshhlt......hs...puc....lhGlDhopctlphA+p....ptpphshp..slpFht...u-lpp.ls...ht........ppaDl........llsp..................ssl.......thhss.tpslp..............phhclL+ssGhlhhtshs.....................t.......tthppp.p.................................ttpchhph......hppuG	................................................................................h...stplLD..lG.C......G..s...G....h.h.s..h..t..lA.............................p.........ssp................................lh..G....l....D.......h.........o......t........p......h......l......p.....h...A....pp............................p..h....p......t................s.....h.p............s...........l....p...a..h..p........................us...h....p..p......l..s........ht....................ppa..D.l..........................................l...l.s..p...............................................................................................................tsh...........................th.h...t....s..........p....p....h...h..p....................................................p.h....h....p....h....L...p...s...s...G..h..l...h..h....t........................................................................................................................................................htthhhhhh.hh.h...h.h............................................................................................................................................................................................................................................................	0	1293	2284	3027
+13690	PF13848	Thioredoxin_6		Thioredoxin-like domain	Coggill P	pcc	Jackhmmer:Q96DN0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.22	0.71	-4.48	54	1636	2012-10-03 14:45:55	2011-02-22 13:44:55	1	33	412	18	956	2074	42	177.40	17	37.01	CHANGED	Fps..tpptt..hctFpcsApphp.c..htFuhs....ppc....lhpp....hthpt..ssllla..+......t.......cp..pphphstp......h.shsslppalpppphsh.ltchs..c.s.htplhppsh..hlllh...hsp.t.sps.h....p.phppt....l..pplA.pph....p..s...p...lh..Fs.......hscsp...th.sc...hlp.hh.shst..s.chPhlshlc.ts.p...t...hhh....h....ps.p.hss....pplppFlps	...................................................................................tt..hp.ahpsApthp........c......h....Fs...hst........stp................lhpp.............hth....pt...s....s......ll.la......+..............................hcp....t..h.apsp................h..st.pp....l.p....p.a.l.....p.p........p....p..........h..........s......l......l..s......c.....h.s.....t....c.....s.....h.t...p..l....h..p.......s.....s....l................h....l....hhh.......hs.....p....s..sps.h...................p..pht.st..............h....ppsA..cpa...............................+..s..........p...........l......Fs........hhctc.......ph.tc....hh....p........h....sl..pt........t...p...h..Pslhl.hs..tp..p...t....hhh...........h......pp..p...hs.....pplppFhp....................................................................................	0	328	470	733
+13692	PF13850	ERGIC_N		Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)	Coggill P	pcc	Jackhmmer:B8ZZK7	Domain	This family is the N-terminal of ERGIC proteins [1], ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, Pfam:PF07970.	27.00	27.00	27.30	27.50	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.07	0.72	-4.01	79	852	2011-02-22 16:17:28	2011-02-22 16:17:28	1	15	295	0	572	795	24	93.90	31	24.37	CHANGED	pL+plDA.as..K.s....s-Dh...ph+.ThuGullTlluhllhlhLhhuEhttY..hsst..hpscLhVDp...s............cuc+LcIslsloFPplPCp...hLolDshDsoG-pphc.l.....p.c	................................l+phDA.as..K.s.....--h....p.p..TtuG..u.h..............lolls.hllhhhLhhsEhttY..h.s.st..hp..clhVDp...s...................pupcl.cINlDlohs.thsCp............hls.lDlh.DhsGcppht...h................................	0	213	335	474
+13693	PF13851	GAS		Growth-arrest specific micro-tubule binding	Coggill P	pcc	Jackhmmer:O95995	Domain	This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localisation of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages [1]. Gas8 is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells.	30.00	30.00	30.00	30.60	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.31	0.71	-5.12	31	204	2011-02-22 16:46:04	2011-02-22 16:46:04	1	7	130	0	133	196	5	187.80	36	41.80	CHANGED	spLhcpH-pAFp-hKsYYN-ITpsNLplIpoLK--ltph++p-pcsc+hht-lpp-N+cLsEPLppspp-lpcLc+pLppYp+DKtsLppsKs+lpphccclpsLchEp-lLpp+applppER-pLhp+Fcpslp-lpQKsth+NhlLEpKlpslpcpLEp+-spLpcllpsssl-ss.tlptlspclccllpsKNptIcsL	.............................pLhppHEcAF.......s-hK...........sYYNDIThNNLsLIpoLK-phpch++..p-p+.-+.ht-lttc.N++Ls-PLpcApc-hp-Lp+pLt..p.Yc.+........DKp..tLtssKs+lp..hh.ccclcsLpWEpElLppRapc................lppE...R--Lhp+F....p....ssl.-lQQKsuhKNllLE+KLpsLpptlEp+-sQLsElLssusl-Ps.slp.l.s.......p+lcclLppKNptIccL...........................	0	57	72	108
+13694	PF13852	DUF4197		Protein of unknown function (DUF4197)	Bateman A	agb	Jackhmmer:C7PG16	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 228 and 249 amino acids in length.	24.90	24.90	24.90	38.90	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.04	0.71	-4.78	102	258	2011-02-22 16:53:23	2011-02-22 16:53:23	1	3	244	0	119	277	75	201.50	38	83.83	CHANGED	ssusLossphssG.LKcALphGsppAVspLupp...sGFhsNstl+I.LPppLpcssphL+pl..Ghu...phsDchhhshNRAAEsAsscApslhhsAl+pMolsDA+sILp.Gu.-sAATpYhcppTpspLtspFtPllppuhsclGssphasslh.........................s..ph................sslsh....spp....hss.sLssYVTpcAL-GLFthlApEEppIRpsP.supsosLL++VFG	......................sh.ssLops-hsuG.LK-ALspGsptAVspLups...sGFhsNstV+I.LP..sp..Lp.cssphl+ph.....GhG.........s.sDpl.tuhNRAAEsAVspAp.slhlcA.l+pMols.DA+sILp.Gu.csAATpYLcppopppLtscFhPlVcpuhsc.....VG.....hsptYsshs......................s.ph...................sslsh...........lss..hsssLpsYVTpcAL-GLFphlAccEppIRpsP.supsTsLL+KVFG.....................................	0	47	98	113
+13695	PF13853	7tm_4		Olfactory receptor	Coggill P	pcc	Jackhmmer:Q9H342	Family	The members of this family are transmembrane olfactory receptors.	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.99	0.71	-4.39	118	25558	2012-10-03 04:04:29	2011-02-23 09:06:22	1	29	180	0	14828	27096	3	143.20	33	48.90	CHANGED	sssthhsuus..hsuGhLp.ul.l.HT..us.TF...sLshC...p..s.s...c...p.Fhs-hPt.lLK.LSCS-o.al.pEl..slllhus.hlshssFlhIllSYlpIhpAVLRIPSppGR+.KAFSTChsHLsVVSLFhuTshFsYL+P.s......Shu..SsshDlll....oVLYoVVPP	...........................................................................................................hChh.L.s..s.s.u..a..h.h..G..h..l..t..u.l...h..p.s.......h.h...hh......pL.s..FCt........sN...h.I.....s..H.Fa.C..-..hs........sl.l..+....L.u.C..u..D..T....t.l...scl...........hh.....h...h...h....u.s.....h..h.hhh..........s..h.h.h.I..l..h.S.Y.s...h.I....l.t....s.l.......L..+...l...t......S...s.....p.......G..R.p....KA.F....S.TCu.S...HL.s.VV.s.lF....YGss.l...h..h.Y.lpP..p.......u.s.p..............s.........p....h....cplh......ulhYollsP.......................................................................................................	0	416	451	1888
+13696	PF13854	Kelch_5		Kelch motif	Coggill P	pcc	Jackhmmer:A8MU55	Repeat	The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure [3] as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.	27.00	20.00	27.00	20.00	26.90	19.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-8.12	0.72	-3.94	78	1509	2012-10-05 17:30:43	2011-02-23 09:06:54	1	435	312	0	1094	6146	187	42.50	25	6.40	CHANGED	hP.ss..ptp.tss.s.....h.s.....s.............tp......lal...aGGhs...........psps..h..s.cla...lL...slss....h	..................................................P..s..Rhs.Hss.s.......................s.h.......s................sp......................l.al........aG..G..hs.............................psth..........h......s.D...la.....hh..sh......................................	0	445	651	900
+13697	PF13855	LRR_8		Leucine rich repeat	Coggill P	pcc	Jackhmer:JCS-Target417241	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.36	0.72	-4.21	93	70869	2012-10-02 21:32:02	2011-02-23 12:42:34	1	6305	1468	377	38112	83275	1324	59.50	28	22.98	CHANGED	spLppLpLs..p.N.plp.tl..sp.ssFp.sl...spLp.hLsLs.tNpl..p..sl..ss.p.s...hpsLtpLptLpLs.s.N.p.l	.....................................tLptLp.Ls.......p..N...pl....p...pl...........ss...t..s..Fp....s...L..........sp...L..p...t...L.....s.....L.....s...p......N.....p...l....p........sl......ss...t..s...............h..p...s...L.....p.....p...L..p..t..L..pLs..t.Npl......................................	0	11072	17914	27457
+13698	PF13856	Gifsy-2		ATP-binding sugar transporter from pro-phage	Coggill P	pcc	pdb_2pp6	Domain	Members of this short family are putative ATP-binding sugar transporter-like protein.	22.90	22.90	22.90	23.00	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.98	0.72	-3.85	23	319	2012-10-01 22:58:23	2011-02-23 17:08:29	1	1	266	1	22	351	15	88.50	45	95.50	CHANGED	hsssFDphhupsDssIh..phMGpphpIsG.....tshhuVhD-s.s.ht..............slpGsuhoLslaoushht.P++sDpl..shsGcpahVsRhph.s.GphhlhL	.......................s.Fpthh.tcMDslTl...+c..MG.+.pAsINs.......sshs.VlPsEphAEh.s..............ALSGs...ulSLVV..F....Sus.YR...P+RGDpV..Vac......G..pp....aTVTRa-paN..GKPhIal.................	0	5	9	17
+13699	PF13857	Ank_5		Ankyrin repeats (many copies)	Coggill P	pcc	Jackhmmer:P42771	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.76	0.72	-3.57	81	5157	2012-10-02 12:10:21	2011-02-24 13:31:59	1	1642	768	6	3250	58643	3660	54.20	29	7.93	CHANGED	Llpps...shtt.sttt....ssLthAsp.tsphphlphLl....t.thshphpstps.tsslchA	............................................t...ss.hst.p..s...p.p.Gp...............TsLHh...A.u.....t..p.....G....p....h....c......l....lchLL............pt..G.A.c..h....s.h..psp.pG..pTsLphA.............................	0	1425	1883	2549
+13700	PF13858	DUF4199		Protein of unknown function (DUF4199)	Bateman A	agb	Jackhmmer:C7PPF0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 167 and 182 amino acids in length.	27.00	27.00	27.10	28.80	26.60	26.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.20	0.71	-4.32	97	280	2011-02-24 17:30:07	2011-02-24 17:30:07	1	1	202	0	108	296	198	157.40	18	90.11	CHANGED	paGhhhGlhhhl..hhllhhhhh....s.ths.t.hh......shh..hllslshh...hhul+pa+pphhsG.hhoatpuhthGhhhshluullhslhphlahphl..sPsahpphhptt..t...t....ht.s.t.hp.t..htth...ht..t..t..............hthhh.shhtslhhGhllollhuh.lh+..pp	........................auhhhGhhhhl.hhlltahhh.h.....shphshhshl.....shh...hllslhhh...........hhtl+paRp..p..h.hsG..hloatcuhhhuhhhhhhuullsslhpala..hphl..-s.sahtphhpth.hp............t....htts.thhp..tth.pth.....th..p.hps.......................hphsh..hhhtslhhGhllulhhuh.hh++.......................................	0	50	93	107
+13701	PF13859	BNR_3		BNR repeat-like domain	Coggill P	pcc	Jackhmmer:Q99519	Domain	This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.31	0.70	-5.36	201	1305	2012-10-02 00:45:24	2011-02-25 12:47:17	1	12	39	1	486	2085	72	273.70	35	44.51	CHANGED	sPuLlcV.suDVFAVAEAQhp.pp.........................ps...s....s............t...........................st...h....u..htp...........tt....tpt.p....p................p.....p.p.t.hh.cs.........s.......................................p...pp......t....+..............Vs..ls.RPTsllc...Gs..DIYML.............s.....Gp...Y.S.............pp...s...................us.....s.......................sh.s...lh.....................Ls............c........us.....s....s..sp......p.......Wp........................-spsls.......psh.............t..p..........................p......h............LlGGG....GSGVKMc....DG.TLVFP............VE............GT..........KK.p..sstt..........sVSL...IIY.S..pc.....sp...sWpLSKGMSs...........sGCSDPSVVEW...c-...t.KLMMMTACDDG....RRRVYESGDKG-SWTE.......ALGTLS.........RV.WGN..............p............hpushlsut............ss.-....pRs.....VMLVTLPVa......ttst......spc........KGcLHLWL......T..DNTHIVDIGPV.s..pD..D..D.sAASSL.LYKSup........s.sspcEELIALYE	..............................................................................................................................................................................PuLlps..sus.lh.AhA-uphttt.......................tt...t..................................h.hs.t..................s.t.t...p............pt.......h...tt..t...........................................................................................................................................................t.t.t.p...............s.t..l.....p..PT..s.h..sp.....ss.........pla...h...L..............s....Gp....a.s..........................ppt.................ttt..............................................................ph.slh...............ls...........c..........sp....s..tt....p...........Wp......ps..ts.l......t................p...................................................p.......t........h.lu..uG.G.SG...l.h.hp.......D.G....TL....V..FPlp............ut.............ppt...tt..................h..Sh....lha...o.p.s.......s..p...s...W..p...l.o....p....s.ho.s.......................sG....C..t...sP.sl.sE..W.......c.....t....c.....L.h....M.h.........s..s....C.c...s..G...........p....p+.V..Y..E.S.s.DhGpoWT..E.....Al..G..T.Lo..+V..Wu..s...pp............t.tuthlpu.............ss.-.t+pV.ML.hT..sh.......tpt......tpt.....cstL.aLWl......T.DN.....s+.hhslGP.....l.....ts...-...s.s.s....A...S..o.LLYpsst................hh.......................................................................................................................................................	0	14	25	486
+13702	PF13860	FlgD_ig		FlgD Ig-like domain	Bateman A	agb	Bateman A	Domain	This domains has an immunoglobulin like beta sandwich fold. It is found in the FlgD protein the flagellar hook capping protein. THe structure for this domain shows that it is inserted within a TUDOR like beta barrel domain [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.80	0.72	-4.24	102	1909	2012-10-03 16:25:20	2011-02-25 14:24:35	1	97	1529	5	465	1365	1800	80.40	26	23.53	CHANGED	usth..........hsss............tsshp..Lsssusss..plpltDs.sGplV..pshsl...sspsu..GthsasWD.GpsssGp.....................tlssGp.Yslpl..........pu.psss	..........................sttsss.........sss.....tshslp..L.tp.su..s....p..l....slp.IpDp.sGplV........+T.l.s.l............G.s.h..........su....G.s..t......s.....Fs.....WD....Gp.s.ssGs...................................sh..s.s..Gs..Yslplsusst.t.................................	0	162	299	386
+13703	PF13861	FLgD_tudor		FlgD Tudor-like domain	Bateman A	agb	Bateman A	Domain	This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it [1].  However in some firmicute proteins this inserted domain is absent such as Q67K21.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null --hand HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.00	0.72	-3.97	107	1425	2011-02-25 14:57:41	2011-02-25 14:57:41	1	6	1242	5	295	834	103	141.10	27	59.41	CHANGED	sspshpuuuhlG+pVhssus.th..........tsss..................tsshp..lsssusss....plpltDu.sGplV..pshsl...sspsu..G.hsasWD.....GpsssGp....................tlssGp.Yslpl..........pu.psss.....tthshsshstupVsuVphs..u.sss.hLsl.ssst.....lshsslpplt	.............................ssQuLQAosLIG+sVhlsGsslhhssssptsussthsstssphttssspsssslssp...........................................................sluphsuGspshsWsGppssGsssssGpYshshsusssGsphsspshthuhVpuVhhs....u.sss.hLsL.Gshut....ssLscVppl.h.............	0	63	154	224
+13704	PF13862	BCIP		p21-C-terminal region-binding protein	Coggill P	pcc	Jackhmmer:Q9P287	Family	This family of p21-binding proteins is important as a modulator of p21 activity. The domain binds the C-terminal region of p21 in a ternary complex with CDK2, which results in inhibition of the kinase activity of CDK2.	20.70	20.70	21.50	25.50	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.30	0.71	-4.80	87	360	2011-02-28 11:44:46	2011-02-28 11:44:46	1	3	298	0	238	367	11	198.30	28	65.46	CHANGED	-h..lsVDF-hasss.s.sDaHulKp..LLpQLhs...s...sp..hsl.up.........LuDlIlsQ......s...s...lGoslKs............................Ds..c....-.......s.-sau.hlollNlppp.................p...s..p.....slcpLtcalhp+sp................sps.hh....ppLpplLs.............s.s..sp....p......lGLllsERhlNhPspllPPhaphLh-ElptAtp........cp...............c.aphs.aaLllo+sY...........................cp.................tp....ttp.ptt..ttp...pp.................................................sE.......hhah+sEDEhht	.............................-.VslDF-has.p.s.sDacGlKp..LLpQLa....p.....s..hsh.up........................LsDLIlpQ.......sp...lGoslK....................................Ds..c-...............s-s...au.hlolLNL......ppp.......................+...s..p.....slpplpcalhppsp.......................pps.hh....ppLpplLs...............................ss....sp....plGLlloERhlNhPsplssPhap.Lh.cElptAhp........sp....................csaphs.aaLllo+sa......................................pc.....................tt.....ttp.p.pt..ppppp............................................pc.....hhahpsE-Ehh................................................................................	0	82	134	194
+13705	PF13863	DUF4200		Domain of unknown function (DUF4200)	Coggill P	pcc	Jackhmmer:A6NFT4	Family	This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.	28.90	28.90	28.90	28.90	28.70	28.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.52	0.71	-4.18	69	384	2011-02-28 13:40:14	2011-02-28 13:40:14	1	8	119	0	261	380	4	125.20	24	29.05	CHANGED	phlcp+REhhphpptlcpp+.cch...pcppcthpp+ccplpcpppcLpcphh.caspFlp-scsK+pcA.+chppEpptcpphpp-lpclppplspLpppppclcpp.lpphp.YpcaLcp.........Vlp.......tss.......p.......app	......................................hlpc+R-hhhhphsLptK+.pch........p+hppthpp+ccpLppp-ppLccchh..pF-cF...lc....-N-p+phcAh+p....ApcEpct+tp+ptElcclptplptlc.schp+hcpp.lpch.........phYpcaLpp....ls.p.....................................	0	133	157	201
+13706	PF13864	Enkurin		Calmodulin-binding	Coggill P	pcc	Jackhmmer:Q8TC29	Family	This is a family of apparent calmodulin-binding proteins found at high levels in the testis and vomeronasal organ and at lower levels in certain other tissues [1]. Enkurin is a scaffold protein that binds PI3 kinase to sperm transient receptor potential (canonical) (TRPC) channels. The mammalian transient receptor potential (canonical) channels are the primary candidates for the Ca(2+) entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC [2].  Calmodulin binds to the C-terminus of all TRPC channels, and dissociation of calmodulin from TRPC4 results in profound activation of the channel [3].	23.00	23.00	23.00	23.70	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.26	0.72	-3.79	54	314	2011-02-28 14:56:46	2011-02-28 14:56:46	1	5	133	0	205	315	3	96.40	26	32.90	CHANGED	G...clPpYLpcpKc.chtcp..pc......phcp.h.tc.p......ts......suhphlsEcERhphLpsL+pphcplppchp.plshh..hD.Thst+pRKpclEccLpplEcsIchhs+spV	....................................................GplPpYLh.cp.+c.phpct..pc................th.pp....tc.t............t.........................suhphls-pERtphL...psL+pphppltp-hp.plshh..hD..Tltt+p+KtclEccLpplEcsIphhp+.p..................	0	92	109	161
+13707	PF13865	FoP_duplication		C-terminal duplication domain of Friend of PRMT1	Coggill P	pcc	Jackhmmer:Q5T7Y9	Family	Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.19	0.72	-3.54	26	408	2011-02-28 15:48:16	2011-02-28 15:48:16	1	13	203	0	273	388	0	70.80	26	28.25	CHANGED	ss.............tssptGphp..tsptsttG+sRu+ssRpspsttt...tsthopE-LDtELDpYM.......ussKscLDt-L-sYhpttt.p	..............................................................................................ttstt......tGtht.....tupsstsupupu+....utpt...s.p.uttpt.....c.thosE-LDs-LDsYh...........st...................t.....................	0	89	131	201
+13708	PF13866	zf-SAP30		SAP30 zinc-finger	Coggill P	pcc	Jackhmmer:Q9HAJ7	Domain	SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two beta-strands and two alpha-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure revealed a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 zn-finger motif indicated a strong preference for nucleic acid substrates. The zinc-finger of SAP3 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex [1].	25.00	25.00	29.30	28.60	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.86	0.72	-4.33	5	123	2011-02-28 17:15:49	2011-02-28 17:15:49	1	2	78	2	78	124	0	71.50	65	39.79	CHANGED	PuAAGPtsGQlCCL..RE-GE..RCGRPAGNASFSKRIQKSISQKKVKI-LDKosRHLYICDFHKNLIQSVRN+RKRKsSD.D	...........................h.sQ.CCL......l-DGE..RCsRsAGNASaSKRIQKoloQK.KLKLslD+SsR.HLYICDaHKNhIQSVRNK.RKRKsSDDt..................	0	18	23	45
+13709	PF13867	SAP30_Sin3_bdg		Sin3 binding region of histone deacetylase complex subunit SAP30	Coggill P	pcc	Jackhmmer:Q9HAJ7	Family	This C-terminal domain of the SAP30 proteins appears to be the binding region for Sin3.	22.20	22.20	22.90	22.20	21.50	20.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.56	0.72	-4.09	36	333	2011-03-01 09:59:32	2011-03-01 09:59:32	1	8	234	1	224	313	0	51.20	37	25.43	CHANGED	LpsssL......+RYp+.taplstt...sssK.pQLspsVt+HFpots.lsEp-sIstFlhtl+	.....................LphssL......pRYp+..capltsps...shsK.sQLspsVp+HF.ps.h..s..lsE.p-slshFlYtVK................	0	62	112	168
+13710	PF13868	Trichoplein		Tumour suppressor, Mitostatin	Coggill P	pcc	Jackhmmer:Q8NEH6	Family	Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement.  The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs) [1].	27.00	27.00	27.50	27.50	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-12.75	0.70	-6.05	68	564	2011-03-01 11:50:10	2011-03-01 11:50:10	1	11	126	0	380	548	18	306.30	19	64.55	CHANGED	-pp-El+pLppplptAtssp.RssQltE+cthctcpp.cc-pphsphhct-+p+slpppcccEppctpcptctpptlppQl.cE+cpp+tpptcphtpEcphhpphhcplp-E-ptct.tc+pc+ppphtc-lpchpcpptphKctpcpppccE-p+.lhcahppppc+ccphppcppct.ccc.+-chhp+Ltpp.pctpccpp-h-pLptchhtEEtccct....Rp+-pp-tcc+tchpp-lppscppQhptKppphptptpc-cpphpchlp.phtcpcch-phptpc++tpp.catcplpptlpp+cpp+pppcppphp-tpphp...cppppcpphl-ptR.p+hLpchtsp..shhsK	..................................pppcl+phpphlhtspsht.RssQlt-+p.thptp...pt.pc-p.thtph.hctcpppthpcppppcppcppcph....phtptltpQl.pcp.cpp.+t.tt....tcp.pppEtp.hpp.hhcph.p.t....E-.ppct..tp+t.ppppphpptlpch..pppt..ph+pp...ptpppppt-p+.lhph.h..tpc..pp....c...cp.ph....p....t.cppch....ppp..ppth.h.p....t.l..tp.t..p.c..p.pp.p.t.ch-plht..chhtcphpcc..........cpct...p...p...ctp.p+.chhpc.lhpsctpQht.Kt...pt...h...ttpt...tc...ptt.....hpphhp....t.pp.tpc.cp.ptpcpp...tht.phtptlppp....lppppppt.tppptphpch...p.t.t....p..ttt..pthl..pp.h....................................................	0	166	202	285
+13711	PF13869	NUDIX_2		Nucleotide hydrolase	Coggill P	pcc	Jackhmmer:O43809	Domain	Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, di-nucleoside and diphospho-inositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.	27.00	27.00	27.40	27.00	26.80	26.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.97	25	336	2012-10-02 00:00:35	2011-03-01 14:52:41	1	6	247	29	220	316	2	175.50	52	74.87	CHANGED	pslplYPL.oNYsFusK....-shhc.KD...tolscRhpRh+ssYpppGh.RpoVcullLVHcasaPHlLLLQ.l...sss....h.....aKLPGG+L+sGEs-.l-GLKRKLscpLu..............ss......c..sh...................pssWclG-slGpWWRPsFEs.hYPYlPsHIT+PKEppKLalVpLPc+stFtVPKNh+LlAlPLF-LasN.tpYGshISulPplLSRF	............................................p.slplYPL.oNYTFGoK....Es..E.cD.........sSVsuRhpRhc-cacc..hGM..RRoVEGVLlVHEHshPHlLLLQ.l...uss......F....................FKLPGG.cLpsGE-...............E.lEGLKR.hLs-pLu...............t.....s....uh...............................tp-W.ls.DslupWWRPNFE.s.....YPYlPsHl..T..+..PK......EpKKL..a...lVpLsc+.........thhu.V......P.K.NhKLlAsPLFELYDNsttYGP.lSulPplLSRa.........................	0	77	118	173
+13712	PF13870	DUF4201		Domain of unknown function (DUF4201)	Coggill P	pcc	Jackhmmer:Q2M329	Family	This is a family of coiled-coil proteins from eukaryotes. The function is not known.	27.00	27.00	27.00	27.30	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.97	0.71	-4.83	56	290	2011-03-01 17:10:52	2011-03-01 17:10:52	1	9	106	0	186	284	10	165.80	24	35.01	CHANGED	hppp.csplschRLphlphpcplschppplcphEplu-s...LphhDF.plph-stsLscKIEERNp-Lt+L+pphspslphlsHh+cKhp.......hlppphpph+ppLpctpcphpclRcplhpschc+s+lcppppc..L+ppuulhphPsLhtD.Y-pphpplpphccslcpL+c..phcplptplpt	..................tppcp.hschRLc.hplcppht+hptplcpp-plu.-s...LphlDFpQL.cI-Npphtc+IEER.N.....pELhcL+.tp........sspsl............phlsph+..............cKhp................hhtpc.pphcpcltptpc.ltchcccltpsctp+pphcppppc.L.cpptuh...h..th......Pplh.-.a.pphtphtthcpplpthcc..chp.hphph..t............................	0	83	104	145
+13713	PF13871	Helicase_C_4		Helicase_C-like	Coggill P	pcc	Jackhmmer:Q9Y2G9	Domain	Strawberry notch proteins carry DExD/H-box groups and Helicase_C domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes [1].	27.00	27.00	27.20	27.30	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.82	0.70	-4.98	47	482	2012-10-05 12:31:09	2011-03-02 11:29:27	1	25	252	0	257	484	56	240.40	40	21.03	CHANGED	ssLDpllpchG..sc.tVAElTGRptRl...Vpp.p..sG....p.hthcpRsss...........sNlsEppsFMsGcKtlhlhS-AGuT.....GhShHADhpstN.Q..RRRVHhhLEhsWpADpAIQthGRTHRoNQsssPhac.lsTcltGE+RFhSolA+RL-oLGALT+GpRpsusp.h...................h.up.Nl-osYu+p.ALcphap...tlhtsp....h.............................h................tFhpch.puLp.l.l....................ps.psG.......shp.-.....c......s..sIspFLNRlLuLslchQNsLFphFpphlpshlcpA+tsGp..aDhGlps	..................................................sLDpllpphG..s-.tVAEh.....T.GRptRl....Vpp.s....cG....................p.lhh-sRstt.......................hNhtEpptFMsG.c..K..........tlhIh.S.-Auuo.....GhShpA......Dtps....pN...Q....R+RVH................hhLEhsWpADpAIQth...GRTHRoNQss..s.P..ah..hlho-l.tGE......+.RFsShlA....+RL-o..LGALT..+GpRcsstp...h...................h.sp..Nh-spYu+p..ALcthhp...tlhttp....h................................................................................pFh.p.ch.tuLhtltl..............................t.pss..........hhp..-.....c.........sIspFLNRlLuhtlchQNt.LFphFtphlsthlptA+ttGp..aDhGl.......................................................................	0	88	144	201
+13714	PF13872	AAA_34		P-loop containing NTP hydrolase pore-1	Coggill P	pcc	Jackhmmer:Q9Y2G9	Domain	\N	27.00	27.00	27.10	28.30	24.30	23.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.09	0.70	-5.65	39	492	2012-10-05 12:31:09	2011-03-02 11:38:16	1	21	227	0	281	484	52	270.10	45	24.25	CHANGED	utsHP.ssLVESuuMASVuPPtso....Yp...pLPstlls...sGhLSssQLEoVlYAupAHsthLsGta..tt.............t..th..RpGFaLGDGTGsGKGRQlAGIIhDNalpGR+RAlW.lS+SssLlEDAcRDWpslGut..thplhsLu+............................a+.u......cs......s......h......pc......GlLFsTYuTLRus.....t.t....ttctSRLcQllcWhG.p-.............FDG.VIlFDEsHthtN......A......u......uut.........tsSpQGhAGLcLQptLPcARVlYsSATGAoclcNLAYhsRLGLWG.ts.t..PFsstpsFlsAl-pGGlAAMEllARDLKAhGLYlARuLSFcGVEa-llEppLTp-QlplYDsa	.......................................................h...HP.s.lVEouu...h.u..........SVsPPc.t....Yp.....tlst.....thhp..pGhL.SshQLEslhYAspt.Hpt.hL.ssu...........................................R...tGFhlGDGsGlGKGRplA....GlIh-Nal..pG.R.+..+A.............lW.hSh.....SscLh....D.ApRDhp......slG...up....pl.lpsLs+..............................................................hc.u.......c..........hs......h......pc.....G..l...lFsTYu..sLhup.......t.....................tphpoRlpQll....pWhG...pc................................FDG..V...I.lFDE.....sHphpN.....h...s.stt....................tsoppGhAsLcLQ..............ptL.PpAR.V.VYsSATG.A.o..cs+Nh.u.Yh.sR.LGlW................G..ts.t.s.Ft.p............htcFlpAlE.......c..t.G.....VuAMEllAhDhKhpGh..YlA.RpLSFp.GV.pacl.Eh...Ls.......p.hphYst.t........................................................	0	102	162	224
+13715	PF13873	Myb_DNA-bind_5		Myb/SANT-like DNA-binding domain	Coggill P	pcc	Jackhmmer:Q8NCY6	Domain	This presumed domain appears to be related to other Myb/SANT like DNA binding domains.  This family is greatly expanded in arthropods and higher eukaryotes.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.35	0.72	-4.08	40	544	2012-10-04 14:01:12	2011-03-02 13:50:17	1	24	83	0	347	698	0	75.80	23	22.09	CHANGED	Rp.tpFotpEhplLlchlpcppplLhs+tsssss....hptK.scsWcpIspchNu..hus.s.pRohppl+++WpchKppsKc.chtp	..............................Rt.pao.pEpphLlph.lc.pp..hpll...s+pss.t.s.s.....htt.K.p...csWcpIspchNu......hss..s..p..R....shppl++pWpchKtps+cch..t................................	0	96	119	238
+13716	PF13874	Nup54		Nucleoporin complex subunit 54	Coggill P	pcc	Jackhmmer:Q7Z3B4	Domain	This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel.  The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them [1,2].	30.10	30.10	30.90	31.20	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.78	0.71	-4.52	49	335	2011-03-02 14:23:06	2011-03-02 14:23:06	1	13	275	1	231	340	1	138.80	31	29.89	CHANGED	p..Ps..shs.cpWcpAh......pcpPsP.p....hlPV.hhGFp-LtpRhphQcpplsphpthLpplpsp.lspL.p.p+.chpsss+ltct+p+ptpLp+RlLclhsplp..lL+p+Ghs.........Lss-E-clppclpplppclssP.sth......u+lsEL.......hupl........p	................Ps.ssDsthWcpAh......hcsPsP.p..........hlPV.h.hGFp-LtpRhchQcphspptps+Lc.....t....lspp.ls.........p.......L.p+c.phssss+ltph+c+phpLs+RhLpl.....ht+hp..lh+ppGhu............................lps-EEpLpppLpplppplp..sP...sthp..........uRhpELhuph....................................................	0	77	125	187
+13717	PF13875	DUF4202		Domain of unknown function (DUF4202)	Bateman A	agb	Jackhmmer:A1B4I0	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 187 and 205 amino acids in length. There are two conserved sequence motifs: LED and KMS. The function of these proteins is unknown, although many are incorrectly annotated as glutamyl tRNA synthetases.	21.60	21.60	25.70	25.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.19	0.71	-4.64	51	144	2011-03-05 16:24:37	2011-03-05 16:24:37	1	6	142	0	91	151	13	182.80	41	82.94	CHANGED	appAlstIDsApupDPspp...h......p....spshPtELhYup+MochL.............p+hsPs.ASE..............sLpLAsRuQHlcRWclPRusYPhs+sGYhpWRssLtphHAphssplh.....hpuGYsppphpRVutllcKcsl.....K......p.............Ds-sQsLEDVACLVFL-chhtsFsppH...D.--KllcIlcKTWtKMS-cG+phALp..lsLs-phtsLlt	..........................ppAlthIDtApspDPpt...h..........s..spshPhELhYAp+MocaL.............tph.pP.s....A.....S-..............hLp.LAsRuQHlcRWclPRssYPhsRs.GYhpWRssLtptpAspssclh.....hpsGYspp-hpRVusLlpK.csL......K..p..................Ds-sQsLEDVACLVFL-c.Fp..pFtpc+.................D--KhlsIlcKTWtKMSpcG+phALp..lp..hs-phttLl.t....................................	0	23	57	76
+13718	PF13876	Phage_gp49_66		Phage protein (N4 Gp49/phage Sf6 gene 66) family	Bateman A	agb	Jackhmmer:A1B8I7	Family	This family of phage proteins is functionally uncharacterised. The family includes bacteriophage Sf6 gene 66 Swiss:Q716B1 as well as phage N4 GP49 protein Swiss:A0MZD7. Proteins in this family are typically between 87 and 154 amino acids in length. There is a conserved NGF sequence motif.	27.00	27.00	29.70	29.50	25.10	24.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.62	0.72	-3.91	52	176	2011-03-05 16:37:05	2011-03-05 16:37:05	1	4	160	0	15	139	2	88.40	41	69.80	CHANGED	+lT.ppl-shIsppp......Yhsttst...................................plTlCslsLcNGFpVs.GcSAC.lsPpNFDsElGcclAcc....sAhsKlW.LEGY..hL+ppLt	......................+lT.ppI-ulItppp......Yhstts.sh..................................hlThCllsLcNGFsVs..GcSAC.ssPcNFDsEIGc+lA+p....sAhsKIW.LEGYhLppph.t.......	0	4	8	12
+13719	PF13877	RPAP3_C		Potential Monad-binding region of RPAP3	Coggill P	pcc	Jackhmmer:Q8IW40	Domain	This domain is found at the C-terminus of RNA-polymerase II-associated proteins.  These proteins bind to Monad and are involved in regulating apoptosis.\	\	They contain TPR-repeats towards the N_terminus.	23.00	23.00	23.50	23.90	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.81	0.72	-4.01	50	325	2011-03-07 13:33:25	2011-03-07 13:33:25	1	54	161	0	200	314	1	93.70	25	18.61	CHANGED	.ss.Ppsuh-Ftpsa+plt..t......sss........tphpaLppl....ssssLsplFps.slss-hLtpllpslp.....ph...hh.pc....p.s.....hshphLptLscspRFchhl.hhluss-Kp	...........................PpsuhcFtpsa+plt..s........sss..........tphphLppl.......sPsplsplFps.sLsschlspllp.sLp.....................sh...hh.p-.....................t.s................hlhphLppLupspRF....shhl.hhhSps-K...........................	0	70	97	145
+13720	PF13878	zf-C2H2_3		zinc-finger of acetyl-transferase ESCO	Coggill P	pcc	Jackhmmer:Q5FWF5	Domain	\N	21.70	21.70	21.70	22.30	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.14	0.72	-4.39	43	338	2011-03-07 14:47:26	2011-03-07 14:47:26	1	11	245	0	223	333	2	40.40	39	8.27	CHANGED	QhhLDhGQpp.h.s.t.p.pCspCGMhYssuss-DpphHp+aHpph	.............QhhlDh..G.Qcp...hs.t...h.pCspCGMhYssu.ssEDct.HppaHpp....	1	57	100	161
+13721	PF13879	KIAA1430		KIAA1430 homologue	Coggill P	pcc	Jackhmmer:B2RV13	Family	This is a family of KIAA1430 homologues.  The function is not known.	23.00	23.00	23.30	23.00	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.42	0.72	-3.57	46	280	2011-03-07 14:58:15	2011-03-07 14:58:15	1	16	112	0	222	284	2	98.40	23	30.14	CHANGED	tH.pp+lpph+...s........slcsps.......Ppp.ht.......phh...hphpph.phpp.........p+h......pcIp+....-NphLlp+ls..cIt.cppsph...stp.p...........ttp................csls...tp...pRpcE.ht+...IscENpplh+Rlpp	...............................chp+l.php...s........tlDsp.........Ptt.ht......thh...hp..h+ph..phpp...............-+hppI-+....-NphLLp+lsplt..cptsph....sph..pp..........h..................................................pshs....t.pRp+c..t+...IptEN...tlhcRlp.h........................................	0	119	142	181
+13722	PF13880	Acetyltransf_13		ESCO1/2 acetyl-transferase	Coggill P	pcc	Jackhmmer:Q5FWF5	Domain	\N	21.60	21.60	21.60	21.80	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.08	0.72	-4.23	40	326	2012-10-02 22:59:21	2011-03-07 14:59:05	1	6	233	0	213	325	10	69.20	42	14.58	CHANGED	shsAhCGlsRIWVpsppRR+GIAocLlDslRssFl.aGhplspsplAFSpPTssGpthAppYsss....ss..FLVY	......sAlCGISRIWVhshtRR+uIAo+LlDsl.Rs..s.Fl.aGthl.........s.........+p.....plAFSpPTssGphhAppYsss....sp..ahlY......................	1	57	94	154
+13723	PF13881	Rad60-SLD_2		Ubiquitin-2 like Rad60 SUMO-like	Coggill P	pcc	Jackhmmer:O95164	Domain	\N	23.00	12.00	23.00	12.00	22.90	11.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.50	0.72	-4.18	24	319	2012-10-03 10:59:06	2011-03-07 16:02:45	1	4	202	3	206	1807	27	106.70	29	62.84	CHANGED	-.lElKFRLs..DGoDIGPhpass.uoTVusLK-pllu.pW............P+-..Kcp.sP+oss-lKLIsuGK.ILE.NN+TLups+..hPhG-lss...slhTMHVVlp.shs-ppsc+p.....psc..s.+pspCsCs	....................................................lpl+hhLh..sGp..ht...hh.ass..ssolsslKcplhs..pW.............................................Pp.-.....hct....ts..p..osst..l+L.I.tG+..hLc...sst......TL....uph+....hshscs.....................slMH.lVs+....s...sc..psptp...........tpp.....t................................................	0	54	105	159
+13724	PF13882	Bravo_FIGEY		Bravo-like intracellular region	Coggill P	pcc	Jackhmmer:C9J6A4	Domain	This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY.  The function is not known.	23.80	23.80	25.40	24.40	23.60	21.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.22	0.72	-3.07	19	521	2011-03-07 16:52:03	2011-03-07 16:52:03	1	69	100	0	165	423	0	86.90	55	7.65	CHANGED	KRs+GGKYs..V+-KEss.pscs-sp....p-..ssFs.........EYpp.ps..sp.sh.p....tupts..stphpsp...sosDShs-YG.-u..ss.spFNEDGSFIGQYusc+cp	............+Rs+GGKYs....VKEKEDs.psDsEhps..hcD...soFs.............EYS......-.....ED.....cK.PLtt.....................uSpss...st.slKtp...............cSDDS.LVDYG.-G..sp.GQFNEDGSFI...GQYouKK-K................	0	29	43	97
+13725	PF13883	Pyrid_oxidase_2		Pyridoxamine 5'-phosphate oxidase	Coggill P	pcc	Jackhmmer:Q8IUH2	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.12	0.71	-4.49	37	676	2012-10-02 11:35:36	2011-03-07 16:55:50	1	10	508	4	389	722	172	156.70	25	61.64	CHANGED	Ps.tc-sAphARhLVppssausluTl..So.......ps.....hpGhPasslhShuDsss...s...susGsPaahLosls.ospslpps.sp..sSloho.sp..............pshspp.........hDPpsP........s.Cs...RlplsGplppl....s......sp-hph..A.ccshhsRHPchppW.ps......HsaaahKLplpsIallshFGG...sphl...ss--Yap	..............................................ARpLlpp..sp.hu.sLuTl......sp............t.............................hpGhP.au.s.hl.shu....................s....sssGpPhhhlS..sl.u.....ps+NL.tss...s+.....sSLhls.tss..................................................................tsss.................................................t.ss...RloLhGphp..l....s.............ssphtt.....s..cpp.ah.ppH.P..c..upha.hsh........tcFtah+l.p.lpp.lh.hluG.FGt...hthl...sspp...t....................................	0	100	209	301
+13726	PF13884	Peptidase_S74		Chaperone of endosialidase	Coggill P	pcc	Rawlings N	Domain	This is the very C-terminal, chaperone, domain of the bacteriophage protein endosialidase. It releases itself, via the serine-lysine dyad at the N-terminus, from the remainder of the end-tail-spike. Cleavage occurs after the threonine which is the final residue of the End-tail-spike family, Pfam:PF12219. The endosialidase protein forms homotrimeric molecules in bacteriophages [1]. The catalytic dyad allows this portion of the molecule to be cleaved from the more N-terminal region such that the latter can fold and presumably bind to DNA.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.88	0.72	-3.84	244	1011	2011-03-09 16:45:01	2011-03-09 16:45:01	1	59	650	2	275	946	2602	57.10	29	7.10	CHANGED	SDpRhKpsI.psl.ps..s...................Lsplpp..lpshsa.....pa....h..................................ttttsp.pch..GhIAQ-lpplhPc	.......................SDpRhKpsI..psl..ss.u...................Lcplpp....lph..h..pY....pap.........................................................tpstp..pch..GlIAQ-lpplhP.................................	0	109	164	224
+13727	PF13885	Keratin_B2_2		Keratin, high sulfur B2 protein	Coggill P	pcc	Jackhmmer:Q6L8G4	Family	\N	23.00	10.00	23.00	10.00	22.80	9.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.60	0.72	-10.95	0.72	-4.24	95	2411	2012-10-03 03:07:01	2011-03-09 16:51:25	1	24	43	0	981	3770	23	46.10	43	80.47	CHANGED	CCpPs.CCpsoC..CpsoCC.pP..oC...CpsoCC..p.soCCpP.sC....Cp..ss..CC.pPs	..................................CCp.ss..C.....C..p..P..o..C.......C.p.....s..o.C....C.pP.....s.C..........C.p.s....s..C.C.....p...s.....s...C....C.......c.P....sC..........Ch.......ss....CC.ps.............................................	0	183	188	227
+13728	PF13886	DUF4203		Domain of unknown function (DUF4203)	Coggill P	pcc	Jackhmmer:Q9NS93	Family	This is the N-terminal region of 7tm proteins.  The function is not known.	29.20	29.20	30.10	29.50	29.10	29.10	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.66	0.70	-4.87	33	330	2011-03-09 17:08:44	2011-03-09 17:08:44	1	7	171	0	235	299	5	186.80	25	38.80	CHANGED	sllsslhs.lhGllhshhGaRha+shh.Fl.....sGahhuuhlshllh....hphps.........hssththtsshls.GlssGlllhhl.hshh.hshGlhhhGllhGhhluhhhhhshhsph.hhhp.s.hshh..h..h..hhshullsul..lsLthp+.hhsIluoulhGushlhhulDhFhps.tlp.hh.htlhtphhsps..h.thh.shPhsh.........salhLusasllhlhGlllQh+	..................................................t.lhsshhh.lhGlhhshhGaRhh+shh..Fh.....sGhhhuuhhh.hl...Lh.....hp.ps................htpph...htsshhsulhh...Gl.hhshh..hshh.hshulhhsGllhGhhlu.hhh.h..h.h..s.th....p.s.s.hsh.h...............sh..hhshull..hsl..lsl.th.+...hhsll.uoulhGushlshulDhahps...l...h.h.lh................tc.h..p.....h.th........s...Phsh..............hlhluhhshlslhGlhhQh+......................................	0	82	113	176
+13729	PF13887	MRF_C1		Myelin gene regulatory factor -C-terminal domain 1	Coggill P	pcc	Jackhmmer:Q9Y2G1	Domain	This domain is found just downstream of Peptidase_S74, Pfam:PF13884.  The function is not known.	24.10	24.10	24.10	26.90	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.62	0.72	-4.93	31	153	2011-03-10 11:00:22	2011-03-10 11:00:22	1	9	79	0	92	129	0	35.90	68	3.83	CHANGED	LlVNK.....-RIFMENVGAVKELCKlTssLETRI-c.L.....ERh	.........................LhVNK.................-RIFMENVGAVKELCKLTsNLEoRI-E.LE+W.............	0	24	30	59
+13730	PF13888	MRF_C2		Myelin gene regulatory factor C-terminal domain 2	Coggill P	pcc	Jackhmmer:Q9Y2G1	Domain	This domain is found further downstream of Peptidase_S74, Pfam:PF13884, and MRF_C1, Pfam:PF13887.  The function is not known.	22.10	22.10	22.10	23.10	21.50	21.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.18	0.71	-4.38	5	132	2011-03-10 11:11:45	2011-03-10 11:11:45	1	9	52	0	64	109	0	132.00	41	16.50	CHANGED	TIoSIQIlEIQQlID+RYCSsuLpCGPGNYsY+IPVNKaTPTNVKFSLEINTTEPLIVFQCcaTL.GNhCF+uph.....sputsQSpcVstpMTQGYQHIWSLPVAPFpDSTYHFRVAAPDLADCSTDP.as.GpFFTDYFFYFYR+C	.................................................oloSIQlhE.p..IsppYC.ut.s..tCt.......s..G...N..aoYpIPls.ptTP.hp.lploLphNo.o..p..Pl...Vh...Cphs....tp.C.cu...............................uh.p.p..h..c.sp....p..p..TQGh.p....H.hWslslhsFp-.sYHFRVAhs..s....As.CS.o....-s.hh....hTDYaFaFYRhC.......	0	12	16	33
+13731	PF13889	Chromosome_seg	DUF4204;	Chromosome segregation during meiosis	Wood V, Coggill P	pcc	Jackhmmer:Q32MH5	Family	The proteins come from eukaryotes, plants and animals, and are necessary for chromosome segregation during meiosis.	21.60	21.60	23.30	22.10	21.30	19.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-9.00	0.72	-4.09	23	266	2011-03-10 12:01:03	2011-03-10 12:01:03	1	4	170	0	181	269	0	62.40	45	8.09	CHANGED	ssLRYAlHLRFhsP.................p..............................cpRaYLYssIRVVFspRps..DuDEu.............cL+s.hcaPss.......P..........+Yhsh	...............................................lLRYLlHLRFpss..................p...............................................pGRhYLasDIRllFupRs...-sDpu.............cL+s.schPps.......P.+aSPh...................	0	38	76	124
+13732	PF13890	Rab3-GTPase_cat		Rab3 GTPase-activating protein catalytic subunit	Coggill P	pcc	Jackhmmer:Q15042	Family	This family is the probable catalytic subunit of the GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). It is likely to convert active Rab3-GTP to the inactive form Rab3-GDP.  Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. This complex interacts with DMXL2 [1,2,3].	21.80	21.80	21.80	25.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.48	0.71	-4.87	27	198	2011-03-10 13:10:59	2011-03-10 13:10:59	1	5	129	0	135	196	4	158.80	43	18.68	CHANGED	sssppststthcG..thp.....hs.shhLLps.s-slatPhTQcssshTEDhlc-ctphLtphGsstp..upthptp........hQsssLlSDMpAF.................KAANPu.....shhEDFVRWa.S......P+Dal......ppt..sssp..........ps.s...............hsscGpLSpR......Mpt...pG............NhWtclWcsApshPApc.Q+.LFDstcEuEKlLHaLEs	......................................................ts......thpscGphtt....hs..phpLLcs.uEPLYlPlTQ-ss.Ph....TEDhlcEpsEllt+LGsssp..Gsthpsp........hpossLLSDMpuF..................KAANPG.....shLEDFVRWa.S......P+Dal-cp.....shsp..............pss......................................hsh+GpLStR......Mph.....u............NhW....hcsW-sAcPlPAp+.Q+pLFD-s+EAEKVLHaLt.........................	0	51	75	110
+13733	PF13891	zf-C3Hc3H		Potential DNA-binding domain	Coggill P	pcc	Jackhmmer:Q9H9L4	Domain	This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.	27.00	20.00	28.30	20.20	26.20	19.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.03	0.72	-3.91	48	422	2011-03-10 13:43:28	2011-03-10 13:43:28	1	8	116	0	277	413	0	65.20	32	16.65	CHANGED	p..C.....st....ttCpppslshscaChp..HILpDtp...QhLa+tCsh.........ts.ppCs..pPl...psttps......hCshHhp	..................t.C.....ssttCsppsLshscaChp....H..ILpDps...QshF+pCshh........tssppCspPl...csp..ppss.....hCstHh.......................	0	87	123	197
+13734	PF13892	DBINO		DNA-binding domain	Coggill P	pcc	Jackhmmer:P53115	Domain	DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-10.97	0.71	-4.14	27	402	2011-03-10 17:40:01	2011-03-10 17:40:01	1	13	236	0	268	411	1	108.90	33	8.46	CHANGED	t+phspphcplWtsls+KDlsK......spRhhsssppsphtNh+KhApLst+Es......R.+ht.........h+opKs.KDhthRA+RlhREMhsFWK+.E+-ER-hRK+sE....KEAhEptK+-EE.REA+RQpRKLNFLIoQTELYS.HFhu+Klcs...sc..h-	........................................t...............................................................................p....................t..........t......c.....p...p-h..hhK+.-+..pch+.+...t.tp....Kp.t..hEtt+ptEE....t....c...E....sc........R..Q...p.+..+LsFLlpQTELau.HFlsp+hp.....tt.......................	0	78	133	201
+13735	PF13893	RRM_5		RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Coggill P	pcc	JCSG:Target_421317_RF20609A	Domain	The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.54	0.72	-4.12	106	5485	2012-10-02 20:46:34	2011-03-18 17:52:00	1	201	405	27	3107	36633	716	56.70	21	11.51	CHANGED	l.hphhppa.G.p.l..pp.lth.hppp.........ptuhlp...a...s.shpsAppshp..th..s.ssh...h...ts..p..t.lplp...au	.........................................phhsp.a..G..p...l.........tp..l...h..l...hppp...........................sp.A.h..lp..................a........p..shps....A.pp.A.h.p............tL.......s..uph..............h.........tu....p.......lplp.h...................................	0	924	1420	2227
+13736	PF13894	zf-C2H2_4		C2H2-type zinc finger	Bateman A	agb	Jackhmmer	Domain	This family contains a number of divergent C2H2 type zinc fingers.	23.00	9.00	23.00	9.00	22.90	8.90	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.08	0.74	-7.53	0.74	-3.23	594	26727	2012-10-03 11:22:52	2011-03-21 11:17:14	1	4325	623	12	17330	257549	774	24.50	26	7.18	CHANGED	a......tC.......sh......C......s.............p.....p..........a.......ps.....t.....p...p.lp.pHhp..p.p...c	..........................................atC..............sh...........C..............s............................p.......p.....................F..............ss...........p.............p.....p.Lp.pHhp...p.p..................................	0	4311	6366	12692
+13737	PF13895	Ig_2		Immunoglobulin domain	Bateman A	agb	Jackhmmer	Domain	This domain contains immunoglobulin-like domains.	23.80	10.00	23.80	10.00	23.70	9.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.50	0.72	-3.85	70	24350	2012-10-03 02:52:13	2011-03-21 11:49:24	1	2345	524	273	12457	102175	132	89.10	15	18.46	CHANGED	ps..........hlp...sss.......ss.......l..pp..Gpsl..sL.pCp....ss......s......tss..s.p....hp..hh..+.s..............................s......phl.s.......p.s.....................ps..........................a....h.........pp.............s............s...h.s..suGp.YpCps......p..st.s...........s...pt...Sssl.pl.pV	.........................................................................................................................................................h..........................h...........G..p..s..l......sL....p.Cp.....sp.................u............................p..s.......s..p...........h.p.....W...h.......+...s..................................................................................................................................................s.............p..l.s....................p.s..............................................................................pp.......................................................hh...l................ts.................................s......................................s.......h...p......c...s....G...p...Y....p.C.ps............ps...t....h......................t..........p.t..............................................................................................................................................................	0	2991	4093	7204
+13738	PF13896	Glyco_transf_49		Glycosyl-transferase for dystroglycan	Coggill P	pcc	Jackhmmer:O43505	Domain	This glycosyl-transferase brings about the glycosylation of the  alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix [1,2].	27.00	27.00	28.10	27.10	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.83	0.70	-5.33	33	771	2012-10-03 05:28:31	2011-03-21 13:31:38	1	17	123	0	493	733	5	188.60	23	52.85	CHANGED	slThsTHushcaL.csl.sls..c+Wp.GPlSlAlasPGt-hptslssIphlhpssssp....l+chsohHlhFptpc.hs...phs.....h.ps.....hph.shp.....C...sphh.sht....ph...h......t.......acs...ssphsYPlNlhRNlARpuAp.TcalhssDI-lhPSsGhlpph..hphls.p....t.p...........s.p.sppVaVlshFElpss...........s..slPpsKtELhphhpsupAh.FHpclC.pCHpsPshpcWhpts.....cs.s....thsssap...h...sh...p.p....tWEPhYIus...p...s-PhaDERhshcGp.s+hoQsathClhsYp...........FplLssAFLVH+.GIKps...tspts.pt...ch.tp...pt...pphltpchhpEhchhYs	.........................................................................................................................................................................................................................................................................................................hP.N.hRNhAh...........s.hhhh.Dh.-h.h.........shh..h.....t....................................................shhl.hFp.h............................................................................hs...s....p.t....L....h.t.........................t..............h........h.........sp...t.....W.t..........................................h................aEs.hl.............t.......................s...h.h...h..sh.......................h........hth...h..t..hp.....................h.lhs.sa.h+...sh............................................................................................................................................	0	224	269	401
+13739	PF13897	GOLD_2		Golgi-dynamics membrane-trafficking	Coggill P	pcc	Jackhmmer:Q6PL24	Domain	Sec14-like Golgi-trafficking  domain The GOLD domain is always found combined with lipid- or membrane-association domains [1].	27.00	27.00	27.50	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.77	0.71	-3.94	11	231	2012-10-03 07:10:23	2011-03-22 13:37:50	1	7	93	0	147	218	0	111.20	47	29.43	CHANGED	VGRGEllTVRVPTHscGopLFWEFATDcYDIGFGVYFEWTsssSs.....sloV+VSESoD-Ec---spp..................tsu-lEpGs.htt...s+.....PplsEIlPVYRRDsHcEVhAGSHpYPGcGVYLLKFDNSYSLWRSKTLYYRVYYT	...............Vt+G-slTlRVPTp.pG.p.hlhWEFATDpYDIGFGlaF...-Ws.ssss.....tloVplS-Ss----p....t-t.................................................tp.ppup......pp.t......t+.............sphsEllPlY...RRDsHp-V.sGSHpYPGcGlYLLKFDNSYSLhRuKolYY+VYY............................................	0	62	73	105
+13740	PF13898	DUF4205		Domain of unknown function (DUF4205)	Coggill P	pcc	Jackhmmer:A8MYZ0	Domain	The proteins in this family are uncharacterised but often named FAM188B.	21.00	21.00	21.00	21.00	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.93	0.70	-5.71	11	398	2011-03-22 14:02:10	2011-03-22 14:02:10	1	11	139	0	269	395	9	225.10	25	57.41	CHANGED	+plLFGoshpsFsp-W+ppsFsFs-s..tltYGLhQt+GGPCGVLAuVQAhlLKtLL..Fspss............th..tshhpssssp+ppsLstALADILWpAGc.ppcAsVsLsssc.phsss.scYptDslpEpLpLashpph--hptFlppals.Fc.pushGsILhlYSsILSRol-plppDhDsss.s....pLlGu.HG.a.CTQElVNLlLTGRAsSNVFNGs.......cpspssh.....s.L+Glts..RS-IGaLoL.....aEH..apsspVGShLKTP+hPIWVlCuE.uHYSVLFsssp-LlsDa+h....E+pF-LYYYDGLssQpctI+..LTVDspupthpss.p......t.p.....clhPPLEhsIRTKWtpAslsWNG	........................................................................h.at............ul.p..p............sG....s....p.ullssl..Quhllp.hl....h..t..............................................................p.phL.....h...sh....t....ll.....................................ht..............t........t...............h..h...................h.................t.................................................................................................................................p............t.................h..........t..h...................h......p.....h...t......p..tph..h...............h................t..h.....at..........t....Gsl.hhhhShlho+uhp..........l.p.t-hpssp....t.............Llts..hs..h..ss...tllNLhLsGpAsstlass.......................................p...th........hhGl.t..pstl.GhLth...............hpt....p...t....p..VGphhKsP.phPlWlhssp.sHhslhFs...p.....tl...t..........................................................................................................................................................................	1	88	117	187
+13741	PF13899	Thioredoxin_7		Thioredoxin-like	Coggill P	pcc	Jackhmmer:O95994	Domain	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.77	0.72	-3.96	51	3155	2012-10-03 14:45:55	2011-03-22 14:27:14	1	52	1979	19	1031	6223	2371	86.30	24	17.25	CHANGED	shhs..sh-pAl.tpApppsKslhl.hh.p..sshC.pCpsh.ccs.hhss.pplpp.lt.c.calhlphsh............sspct.ph.........thtt.......ph.......sPtlhhlss	......................t......hppul..tp..u..p..s......p..s..KP.V.hl..Dh..t..A-W...CssC+..th..c...ch..s..hsc...s......pVpp.....ht..p..s.h..lhlps-h........................sssss..p.............................htp.................hG.................hPtllhhs...........................................................	0	347	605	827
+13742	PF13900	GVQW		Putative binding domain	Coggill P	pcc	Jackhmmer:Q6ZWE1	Domain	This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.	28.10	28.10	28.10	28.10	27.90	28.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.37	0.72	-3.98	35	1257	2012-10-03 02:24:44	2011-03-23 13:28:18	1	170	16	0	72	778	423	41.40	60	18.50	CHANGED	VuQAGVQW+sLGSLQPsPPtFKpFSCLSLPSSWDYR+sPPpPAN.Fs..lF	.............ssQAGVQ...W.p.c..LuS....LQP...P.P..sFK.pFS.CLSLs...SS...WD.Y.R.....p..P.sp...s....h...................	0	55	60	61
+13743	PF13901	DUF4206		Domain of unknown function (DUF4206)	Coggill P	pcc	Jackhmmer:Q9H714	Domain	This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, Pfam:PF00169	27.70	27.70	29.40	28.90	27.50	27.60	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.74	0.71	-4.77	28	498	2011-03-23 16:23:42	2011-03-23 16:23:42	1	18	131	0	302	495	2	187.10	36	26.38	CHANGED	RhCsYsGcYaCsuCHp.s.stssIPARllcsWDFppasVSptuhphLpphhspPLlslpplNPpLYs+scpLsclpplRppLthlcpYlhsCRhus.p.tptt.........hp..t..s+pa.Lhp.s.schYSltDLlplpsG.shtth...LpplhphsppHlt.sC.LCps+GFlC...EhC......pss...clIaPFpp...t.psp+CspCtulaH+pCap...p..ss........CP+CtRhpp+c	.......................................RhCpY.GpYaCs.s.CHt.s.spslIPARll+.pWDFpch..........V..Sph..uhchLp..tlhppP.lhslp....p....lNst.LYp+...s...ctLsplpp.lR.ppL.hhh...+sa....l.......h.....o...CR......ut....p.....h.hp.........hp....ts.pa.L.h...-....s....c.......haSlpDLh.pl..p.pG..t....Lssh................LpplhphstpHlh.pCp........lCpt.+.G.F.lC...EhC.....................pss.......cllFPFp.....ps...p...Ct..pCtus...aH.p.pCht.....p...tt.........CP+C.Rhp...p........................................................................................................	0	93	124	205
+13744	PF13902	R3H-assoc		R3H-associated N-terminal domain	Coggill P	pcc	Jackhmmer:Q96D70	Domain	This family is found at the N-terminus of R3H, Pfam:PF01424, domain-containing proteins.  The function is not known.	25.00	25.00	32.60	28.10	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.75	0.71	-4.19	32	193	2011-03-23 16:27:11	2011-03-23 16:27:11	1	7	156	0	132	182	0	121.20	23	35.98	CHANGED	++phhtcculcpp-slh..u+cGsR+ppRaENc+lLpshhsp..stspp....sshshps.lP............hthsthW.ssahshst-pppphh...pthcsppcpstsptt.......................s.t.ap+ls+cLRttLK+	................................++t.hhppul+pp-slh..spcGpRpppRaENc..+hLhshhsp..ss.sps..ht.tssh.shts.sP..............hphsthW.ssah.s.tst-cpp..phh......pthpp.ptpppt.tp.tt..t...........................................ts.tthpclspchRthl++..................................................................	0	35	65	100
+13745	PF13903	Claudin_2		PMP-22/EMP/MP20/Claudin tight junction	Coggill P	pcc	Jackhmmer:A6NFC5	Family	Members of this family are claudins, that form tight junctions between cells.	31.20	31.20	31.20	31.20	31.10	31.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.43	0.71	-4.57	37	835	2012-10-03 00:20:40	2011-03-24 16:16:45	1	11	100	0	558	2183	0	182.30	16	73.69	CHANGED	hlAlsLllluhsTspW..lp...ss..spp..............pt..............................t.....h.t.t...hh....pp...Gh.ahhshh..................................................h.hhshshhhluh....shs.hhuslht.h.hussp...ps.t................thhhh..s.uh..h.hh.....suus.hhhhslshasthhp......h.......hpp...th..pp.....tsh....hhthGaSFhLsssushlsllsshLhLh	................................................................................................h.huhhhhhhuhs..o..s..h.W..h......hp.....th............................t................................................................................................................h............tp......Gl..a.p...h....Chh.......t.........................................................................................................................................................t..hhh.tht...hh.s...tsh.h.....hl.ul.......sl.h..lhu..h...l..hs....l..h...u..h..hp.......ps.t....................................hhhhs...s..Gh..h.hl................huG.l..hhll...ulh.ha.h.t.t..hp.......h......................h...t........tph.....................phpauWSa.h..lAhsuh.hhthlu.uhlhh.h...............................................................................	0	115	170	350
+13746	PF13904	DUF4207		Domain of unknown function (DUF4207)	Coggill P	pcc	Jackhmmer:Q96HJ3	Family	This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.39	0.70	-5.01	19	192	2011-03-24 17:00:58	2011-03-24 17:00:58	1	4	70	0	84	188	0	234.00	25	57.05	CHANGED	s.Ss.usSspSp..hSsp.....sspsh.tspspspsps....pps..spShsshhcsh.p.............................pocsps.ssls.hphs..spsSs.....tsp.......sah+.plcth+lc+pst....pAY-sWhuuKptp.p.+.ptc.h....ttcpEcc+pc..sthRp+LAcE+YcpWh+pKspQpppp+p.p.pt......tpp........sup.....pustu...........................ss+phs....t-ps+c+lpcW.hcKhcppppcRpcpcptppp+ppccpcR+phuEtAapcWhpsVsp+PKPVPhNQGhcu..LRGTlS......slYlNPh.W	.........................................................................................................................................................................................................h...tts..u..S........t.p....sppp.pstp....p..............h..tsh..............................pspsts.s.h..hp.t............o.......pp.......s..c.p.cp.ch.cps...........tsa-sWhstKpt...pcppp.......t.h.....tpppE+cccct...tttpRppl.A.pppa..ppWhppKpcppppp+t.p.pt......pppts...psthp.....................................p+ph..t-c..sppchppW.hcKhp....ppp..pc....+...pc....pc..ptpt...p+ptp.pcR+phuptAapcWhppscp+s+Pss.hs.Ghs....LpGhhS.............hahNP..W..............................	0	17	22	47
+13747	PF13905	Thioredoxin_8		Thioredoxin-like	Coggill P	pcc	Jackhmmer:Q5VZ03	Domain	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.07	0.72	-3.87	83	2061	2012-10-03 14:45:55	2011-03-25 14:24:33	1	60	711	33	871	11398	5021	94.50	22	26.84	CHANGED	s..+hlllhFhus......hst...t..s......pp.....hhst.Lp.p...h...hpphp.......................tp....lpllhlsh............D...p.s..t.p..ph...pphhpph..............s.hh.shs.hss..t.t......pp..pl..........tpth.s..lps.................l.Pplllls.psGp.....l	..................................Khlll.Fh.us......WCs......s...C..........pt.....hhPp...Lp.c....h...hp.chp..............................tps..hpl..l..h..l..Sh......................................D........c..s....p...c......p..h..........p.p..h.h.pph.........................s...a.h...p......h.s...hss....s.t.........pp....pl...................hpta....s....l.p.u..............................l.P.s....h.llls.tpGp...........................................................	0	370	608	774
+13748	PF13906	AA_permease_C		C-terminus of AA_permease	Coggill P	pcc	Jackhmmer:Q7Z475	Domain	This is the C-terminus of AA-permease enzymes that is not captured by the models Pfam:PF00324 and Pfam:PF13520.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.63	0.72	-4.10	56	923	2012-10-03 01:44:59	2011-03-25 14:26:22	1	16	191	0	595	2651	76	50.00	44	8.37	CHANGED	FpsPhVPhlPsluIhlNlYLhhpLsshTWlRaslWhsl...GhllYhh....YGhpHS	.................FtVPhl...Ph.lPslSIh....lNlYL.MhpL.....st..tT..W...lR..Ful.....W.h...hl...Ghl.l.YFs....YGlppS..............	0	136	243	422
+13749	PF13907	DUF4208		Domain of unknown function (DUF4208)	Coggill P	pcc	Jackhmmer:Q86WR6	Domain	This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins.  The exact function of the domain is undetermined.	23.00	23.00	23.10	23.10	22.50	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.20	0.72	-3.79	31	331	2011-03-25 14:30:37	2011-03-25 14:30:37	1	14	214	0	224	312	0	101.20	32	7.30	CHANGED	sc...s..t.tp.ptc-.h-spshsp..CKchMcPl++sL++Lc+s.sc....uLs+c.-hlphl+ppLhsIGcc....Icpplpph...pps..p.cchcc+LWhaso.pFhs..hc...upKLhphYc+h	.....................................hst....t.ptcph-.p.pshsh.CK-hh+PlKcsLKpLcps...pc..........sL.spc.-plpch+ppLlpIG-+....IsppLpph..........sss...phcpa..+cpL....WhFVS..pFot..hc........uc+LpclY++.h...................	0	52	94	163
+13750	PF13908	Shisa		Wnt and FGF inhibitory regulator	Coggill P	pcc	Jackhmmer:Q8N114	Family	Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.	27.40	27.40	27.40	27.40	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.97	0.71	-12.11	0.71	-4.10	11	427	2011-03-25 14:59:58	2011-03-25 14:59:58	1	13	55	0	239	379	0	153.30	22	54.82	CHANGED	tpGEhCh..hsshsphcPsa.CPp......p.paCCGoCuhpYCCss.h+psphsps.sCss.-p..sh.t....s.......chtpshc.sPs...pshtssllVulhhhVlhl.lshllshsC.pCsL.Kh.....................pR.ppPshopss.usshpppshsQs.st.........sph.P...usph..QsYps.sspsu.......h.ts.h.sh.hs..Ph.h.ssssssY	......................................................s...p.Ch.hahsh.utap..FpCs.............hhhC...CGsC.hRa.CCt....h....p..hp.Qt.tC.s.....................................ss..............h.lhsulh..hh.lh.h..l....hshlss.h.hs.....p.s.h.h.K.................................................pp.....p.......h..t..p...sh....sp.........h.t......t..s........t........................t..s.........p...tth.s....sst.s...............h.........................................................................................................................................................................	0	51	77	135
+13751	PF13909	zf-H2C2_5		C2H2-type zinc-finger domain	Coggill P	pcc	Jackhmmer:Q6IQ32	Domain	\N	25.00	13.60	25.00	13.60	24.90	13.50	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.10	0.73	-7.42	0.73	-3.42	73	3546	2012-10-03 11:22:52	2011-03-25 15:19:35	1	546	228	2	1708	10506	142	24.70	29	7.43	CHANGED	apCst..Cs.ats..p.tp.p.lp.pH.hphh.Hs	.........a+Cph..Cs.apo...s.pp.s.Lp.pH.hppt.H........	0	489	585	1020
+13752	PF13910	DUF4209		Domain of unknown function (DUF4209)	Coggill P	pcc	Jackhmmer:Q5T6L9	Domain	This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.	22.30	22.30	22.40	22.30	21.90	21.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.34	0.72	-3.91	17	134	2011-03-25 16:11:02	2011-03-25 16:11:02	1	2	110	0	71	124	3	91.10	30	15.63	CHANGED	hl...ph.lcptlhsh.hh.shptpts...h..hLp........-lLtscplpphlspsl.............hhlL+hhlssPp..GLNLRNllaHGFls.sphp.phhshllhLhhsls	................................hph..t.h.Rtlhphhhhhsp..ps...........hhLc........-LLs..s....p.pltplhGpsl.............h.lL+lhhssPp..GLNLRNhlhHGah..ssp-lss...phsshhlhLhhtl.s...............	0	32	42	50
+13753	PF13911	AhpC-TSA_2		AhpC/TSA antioxidant enzyme	Coggill P	pcc	Jackhmmer:Q8TBF2 	Domain	This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.75	0.71	-4.16	82	573	2012-10-03 14:45:55	2011-03-25 16:14:57	1	12	263	0	372	774	179	123.50	20	46.43	CHANGED	tLtpt..t..spLpt.....tG..lp..lhs....lu..hush..s...spcFt.ph.....sta..shp.la...........sDs.stphaptLsht.......................................................................................p.hh.h.th..................h.t.......h..t........th.htthtth...........th..tsh.......................................................................suthtQpGGsalhssss......pllapHc-cs	...................................................................................................s.hpt....ts..lp..lls..lu..hush......ts...hcpFt.ph........sta..s..h-..la.............sDs..p.+..phYptLGht...................................................................................................p.s...th.sh..h...sst............htps........h.p..............th..hpthpph...........s.h..ssh..................................................................................pGshhQtGGhhlh........stss.....plhataht............................................................	0	127	219	297
+13754	PF13912	zf-C2H2_6		C2H2-type zinc finger	Coggill P	pcc	Jackhmmer:C9JL96	Domain	\N	25.00	5.00	25.00	7.50	24.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.09	0.72	-7.35	0.72	-3.91	81	8615	2012-10-03 11:22:52	2011-03-25 16:26:12	1	2303	333	9	4881	167936	200	24.80	27	6.24	CHANGED	hapCshCpppF..sshpslhsHK.ppa.ppt	...........apCs.t..C.s...cs.F......ssh.p.s...L..h.tHh..p.h....t..................	0	845	1687	3070
+13755	PF13913	zf-C2HC_2		zinc-finger of a C2HC-type	Coggill P	pcc	Jackhmmer:Q5TFG8	Domain	This family contains a number of divergent C2H2 type zinc fingers.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.00	0.72	-4.21	111	1078	2012-10-03 11:22:52	2011-03-25 17:14:21	1	55	127	0	709	1684	18	24.70	37	10.97	CHANGED	phh.C.thCGRpF.sscplt+H....tphCp	......hh.C..hCGRpF.ss.s.s.l.ppH........shCp..........	0	305	367	517
+13756	PF13914	Phostensin		Phostensin PP1-binding and SH3-binding region	Coggill P	pcc	Jackhmmer:Q4KMQ1	Domain	Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton [1]. Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [2].	25.00	25.00	25.10	25.10	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.63	0.71	-4.04	5	99	2011-03-28 10:56:36	2011-03-28 11:56:36	1	5	42	0	53	90	0	122.60	49	22.28	CHANGED	APQtAK.Psssh...Pup.pLHPA+PGcsutL.pRGuNTFTVVPKRKPGoL...thSQANsposspsAE---AsuL.......Gs......TLKKRYPTVHEIEVIGGYLALpKSCLoKAGSSR..KKMKISFNDKuLpTTFEYPSESSLlQ	.....................................sp.sh...sh.....sh..hass+sG.ssth....pR...uGpTFTVsP+Rpss.............Asst...s.sp.........Ap.t..-sAs.................ss........shKKRYPTscEI.VlGGYLpLp+SCL.sKu..uspR..KphKISFsEsuLpTTapYPSESSllp...	1	6	12	23
+13757	PF13915	DUF4210		Domain of unknown function (DUF4210)	Coggill P	pcc	Jackhmmer:Q32MH5	Domain	This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.	21.20	21.20	24.10	22.70	20.10	19.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.25	0.72	-3.68	21	277	2011-03-28 12:49:58	2011-03-28 13:49:58	1	5	173	0	185	275	0	63.10	49	7.99	CHANGED	LlGSFEESlLpGRhs..P.op.l-GFhAplGloGut......asPtplplPFsshaap.......hu..ssss.....sPYl	..LlGsFE..ESlLpGRhs..P.st.l-GFsAp....lGsoGs...............aCPsHlTLPhsssFYs........sS..-suP.........oPYh....................	0	41	78	126
+13758	PF13916	Phostensin_N		PP1-regulatory protein, Phostensin N-terminal	Coggill P	pcc	Jackhmmer:Q4KMQ1	Domain	Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton [1].  Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [2].	23.00	23.00	24.40	23.50	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.81	0.72	-4.00	4	58	2011-03-28 12:54:51	2011-03-28 13:54:51	1	4	30	0	30	50	0	83.50	56	14.78	CHANGED	s-ps.hotMPAWKRtILERRRAKLuh.sGt..suP.......GsA-.....PsEptVLhEulGPl+QN.Fhp.EppRpptpptttpcLLtch+tsP	..................AER-RLSQMPAWKRGlLERRRAKLGL....uP.....GE..P.uPh.s...................s-uGss-...........PDESuVLLEAIGPVHQNRFIRQERpppp....pp...p......Qp...p.....p-LLt.chpss........................	0	2	8	13
+13759	PF13917	zf-CCHC_3		Zinc knuckle	Coggill P	pcc	Jackhmmer:Q8TBK6	Domain	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag  proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.34	0.72	-4.22	25	384	2012-10-03 11:39:54	2011-03-29 14:02:14	1	40	191	0	234	1569	12	40.60	31	17.55	CHANGED	ssusspCQKCLphGHW...TYECK..........sc+....sYs.......sRPSRTQpLcps.l	........s...pstCpKCh....phG.........Hh..........TaEC+....................tpp...................................................................................	0	90	133	193
+13760	PF13918	PLDc_3		PLD-like domain	Coggill P	pcc	Jackhmmer:Q8N7P1	Domain	\N	27.00	27.00	27.50	27.00	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.12	0.71	-4.84	5	475	2012-10-02 13:01:53	2011-03-29 14:42:38	1	7	150	0	155	456	3	169.10	38	45.75	CHANGED	SluTIKNLGLYSTN.K+LAhDLMNRYNTFSSMls-PKlPFT...RhCCuM.lTPTATsFHLNHoGGGlFFSDSPERFLGFYRTLDEDLVLHRI-uAKNSIDLSLLShVPVlR+uosVcYWPcIhDALLRAAI-RuVRVRlIIopWKNADPLSVAAARSLc-FG..VGslDlSVRhFulPGR	........................................................SloplKpLGlh..hN.spLAhDLtphFpsaasht..s...p..s..p..l.P.o....h.....phsssh..spsss.hph..p.l..s.p............s.s..u.s......lF.....hS.s..SP.pthh..sh.tRThDhDslL.phIcsA+p.I.lulhshlP....lh....c...h.s....s.s......h...p.YW.PtI.suLhcA.A.lpR.uV+VRlLlo.pWc..psDPhth.s.hl+SLp...sh.s........ss...s..ss..lpV..+hFslP.............................	0	40	55	103
+13761	PF13919	ASXH	Asx-hm;	Asx homology domain	Iyer LM, Aravind L, Godzik A, Coggill P	pcc	Manual	Domain	A conserved alpha helical domain with a characteristic LXXLL motif [1] [2]. The LXXLL motif is detected in diverse transcription  factors, coactivators and corepressors and is implicated in mediating interactions between them [3]. The ASXH domain is found in animals, fungi and plants [4] and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade  of DUBs [4].	25.80	25.80	25.80	27.20	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.73	0.71	-4.38	85	311	2012-10-09 14:14:56	2011-03-29 16:45:12	1	10	155	0	174	299	0	133.90	41	12.83	CHANGED	ptps..++hssu.....Qh+ps+.st.cl..DlEoPcSILlsTNL.RuLlN.pcTF.ssLPtphQppLltLLPc.........VDRpsu......................................ssshl+.LssS.sLN.NEFFscAsppW+-RLu-GEFTPEhQ......................h+l+pEtE+E+.KlDsWKE+aFEsaWGpK	...........................................ht.....cp.ttt..phKps+...st...cl...DlE...oPsSIL.l......sT..NL.RA...Ll.N.pcTF.ssLPschQppLLhLLP-.............VDRpsu.........................................s-uhl+..L...ssS..sLN...NEFFspAspsW+-RLu.-..GEF...TPEhQ...............................l+l+..pEhE+EK.......Kh-.WKE+aFEsaaGp.....................................	0	37	66	112
+13762	PF13920	zf-C3HC4_3		Zinc finger, C3HC4 type (RING finger)	Coggill P	pcc	Jackhmmer:Q9BY78	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.78	0.72	-4.29	585	5985	2012-10-03 15:03:13	2011-03-29 16:58:25	1	423	488	23	3675	15063	738	49.20	31	9.50	CHANGED	ppph....Chl.......Ch.s......p.......p..t...s........s.lhh..P....C..s..HhshCtpCuppl......................ppCPl..CRp.slp..ph	.............................p..ttChl.Ch...c.......................p....................t....s........................s..l.h.h.....P........C..u...Hh..hC...ppCupph..................................................ppCPl..CRp.lp..h...........................	0	1260	1981	2858
+13763	PF13921	Myb_DNA-bind_6		Myb-like DNA-binding domain	Coggill P	pcc	Jackhmmer:Q15361	Domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.04	0.72	-3.86	39	4769	2012-10-04 14:01:12	2011-03-30 11:08:35	1	107	621	51	3074	13999	171	61.90	27	16.83	CHANGED	WTp-E-chL....hphhpp........h....u..t........s...WppI.....upt..l.s...........Ros..tpltpRap..p...L..........p.........s.p.......hppss..asc.p-pppL	............................................................WTp.-ED.phL..........hphl...pp...................................a............G...p........................p.....Wsp.I.............upt....l..s.................................Ros..ppC.c.p....R.Wp....p......hL......................p.............s.p.....................hp.p..t.......as..t-.......................................................................................	0	1464	2097	2635
+13764	PF13922	PHD_3		PHD domain of transcriptional enhancer, Asx	Coggill P	pcc	Jackhmmer:Q76L83	Domain	This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.	25.00	25.00	36.40	34.50	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.03	0.72	-3.73	13	166	2011-03-30 10:10:42	2011-03-30 11:10:42	1	4	63	0	89	168	0	65.00	59	4.50	CHANGED	ppt.....tpsps....pstp..h..Qp....ospNT.........................s...pussspCuCuLpAMVlCQpCGAFCHDDCIGsSKLCVSClI	................................................t..s......uupsts..lslQhFs-pss.........................sEshs.KCsCRLK.AMIMC+GC..GAFCHDDCIGPSKLCVuCLV...	0	12	18	41
+13765	PF13923	zf-C3HC4_2		Zinc finger, C3HC4 type (RING finger)	Coggill P	pcc	Jackhmmer:Q5VTB9	Domain	\N	27.00	20.00	27.00	20.00	26.90	19.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.23	0.72	-3.92	345	3897	2012-10-03 15:03:13	2011-03-30 11:46:46	1	230	817	11	2262	19172	876	41.60	35	7.80	CHANGED	CslC.hp.ph.ps.....s.h..hh.s..C..u..H..h.h.C.p.pC...ht..p..h..hpp.t..........p..p....C..Ph..C	...................CslC...hc..hh...pc.................P.h....hs..s....C......G........H....h.F.C.p..pC........lt...c....h..hps..p..............................p...........C..Ph..C..................................	0	782	1217	1747
+13766	PF13924	Lipocalin_5		Lipocalin-like domain	Bateman A	agb	Jackhmmer:C7PBJ6	Domain	This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5 Swiss:B6SEG2 which is involved in biosynthesis of alnumycin [1]. The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein [2]. The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyse a final cyclisation reaction [3].	21.10	21.10	21.60	21.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.80	0.71	-4.49	68	249	2012-10-03 08:47:39	2011-03-30 13:10:08	1	8	197	0	95	228	57	132.90	25	64.70	CHANGED	hG.sWcLlu...hphpss-Gs...................................hhhPhGp.sPpGhlhYsscGhh.osplhptsR......................h.sss.hpuosp-hsp..shpshluYsGpY.....plcss.........plhacl-suhhPsWl..GspQpRphplc.s.....cp...Lhlt...tstshhhsst.tt.....shLsWcRh	..................................................hGsWpLlS...hph...ss.s...................................hhhPhGp...ss...hGhlhYstpG.hhuspl.hsss...Rst....................hsstshhtss..sp.-h....st..shpshluYsGcY.........plccs..........................thlsHpl-suh.hPNWl..Gs.pQpR...h.aphc.t.........-p...LpLt....phssh.hsst.hh.....shLhWp+................................................	0	26	56	76
+13767	PF13925	Katanin_con80		con80 domain of Katanin	Coggill P	pcc	Jackhmmer:Q9P0V8	Domain	The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles [1].  The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein [2].	27.00	27.00	27.20	27.40	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.66	0.71	-4.51	33	279	2011-04-01 14:39:33	2011-04-01 15:39:33	1	12	127	0	176	262	0	145.60	30	26.00	CHANGED	pcsHsshhpsLpsRhppLpslcphW.ppssl+sulsshtph...pDhulLsDlLsllp..t+ppt.....hsL-hCstlLPhlppLLp.S+aEpalpsuLchLptllppFtshIpsshp..ssstsulDlstEpRh...p+sptshppLpplpphlpths.p...psGplGppupcLphhls	...................................psH-shhpsLpuRhtpL.....psshphW.pppslps...slshhhph.........pDhuVl.sDlLslls.......ptph......hsL-hCsslL....Phlp.pLLp.S+a.EpaltsuhshLphllppFhshl.....pst...ht....s.spluVDlptE-.Rh...............ppsphshppLppl.ph..tht.....h.G.hup..hpclp.hh.....................	0	52	80	127
+13768	PF13926	DUF4211		Domain of unknown function (DUF4211)	Coggill P	pcc	Jackhmmer:Q8N4S0	Family	\N	27.00	27.00	28.00	28.00	22.30	21.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.58	0.71	-4.81	38	274	2011-04-01 15:59:20	2011-04-01 16:59:20	1	7	160	0	173	252	0	146.50	23	14.76	CHANGED	c-Flhp-p................t.s...sstsphshphshpsppsh+-pFcshlchhVpstLcssFhpsh.....t.....chahsuhc+l-sp.lpsppcslltsosWsssapcuLcshPplplhth.........psttCpACpcss+ss.shcl+hsGcsY...........spcT......Lpshppsss	.....................................................................................t.....pt..................t.tss....tt.tpsphshttp.h.hspp..sh+-pFcshlchLlppALDPs.hhpsl.c.ppp........chaLssh++lDsh.lpspp...cplltps.thspp...appuLcsaPpl.h........................t.hsCpuCsps.st...shcl+hsGcsY...........NpcT......Lp..ph...s..................................................	0	40	64	114
+13769	PF13927	Ig_3		Immunoglobulin domain	Coggill P	pcc	Jackhmmer:O60384	Domain	This family contains immunoglobulin-like domains.	27.00	15.30	27.00	15.30	26.90	15.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.84	0.72	-3.46	182	4712	2012-10-03 02:52:13	2011-04-04 12:51:01	1	772	224	45	2131	57861	94	77.20	17	13.25	CHANGED	pPplthp.sts.t...............lsLp...Cpstss..........ssphpWh............................tstttttsspsslsls.........hp.....ppsss..asC....hs...ps	.............................................................................................................P.l.h..t.....hts.................lsLp..........C...pupss..............................ssphtWh.......................................................................................t..s...p...t....t....t...s...t......s....p...u....s...ls.ls...................................ssp........................pcsGs.....YpC..hu.p...............................................................................................................	0	498	693	1156
+13770	PF13928	Flocculin_t3		Flocculin type 3 repeat	Bateman A	agb	Jackhmmer:Q5AF39	Repeat	This repeat is found in the Flocculation protein FLO9 Swiss:P39712 close to its C-terminus.	21.90	21.90	22.20	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.62	0.72	-3.80	149	538	2011-04-06 11:49:32	2011-04-06 12:49:32	1	38	52	0	311	544	0	43.50	44	15.50	CHANGED	sTTllTlTSCs.c........spCspos...........l......oTu.so....sls.........ssp..TsYTT..YCPLo	....................pTTllTlTSCp.s........shCopos................V.......oTu..ss....TVs.........sss..ThYTT..aCPlo..................	0	57	149	285
+13771	PF13929	mRNA_stabil		mRNA stabilisation	Eberhardt R	re3	Jackhmmer:Q03153	Family	This domain is an mRNA stabilisation factor [1].	25.00	25.00	57.90	27.50	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.86	0.70	-5.46	7	26	2011-04-06 12:28:04	2011-04-06 13:28:04	1	2	24	0	15	23	0	267.70	34	48.31	CHANGED	hplhpsLsppD....actuppllsssp..p.p.l+sltsslppL.pph....clsscpWhphh-pphPhlh.pps...aWssRhpaapLL.hss.pph................slp...phh.-YLhhKpuhGtplsccDLlsFLplh.pplpsspp....Y.pLVppNphllcALpLac..psc....llhDspllshLLpoMss.ppp....pL+uhYEhlcals..ppat.pths.ssltpllpsLschpsWscLhpFWctthss.s.tpDpRPWs.Fl+slspsGDpplh+cllccGpLLWIpRspVs..hos-LpstLpcLFppus	...................s..hh.hLpppD....Fctuscll.pss..st.sphc..l+olpcshssLpp.s..tpclcsspWpphFDpp.shlshspst......YWslRhcahhLLNcscPphY....................os+...halpDYLlLK+ShGpcLh+-DLluhLchllps.css+p....YhsLVcpNchllcALpLact.psc...tpllhDppVlohLLpoMlsp-cs....+LcuLYEsI-alh...poas.ccLTsshIlsILpsLAch+-WsKLhphW-shsss.s.sp.......DpRPWscFIpllspoGDsplhpKllssGHLLWI+RhsVs..l..oscLpsslctLhcpss......	0	3	8	14
+13772	PF13930	Endonuclea_NS_2		DNA/RNA non-specific endonuclease	Coggill P, Punta M	mp13	Jackhmmer:D0LUR7	Domain	\N	27.00	27.00	27.10	27.00	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.79	0.71	-4.12	50	1121	2012-10-05 18:28:12	2011-04-06 14:28:53	1	34	776	3	170	1036	12	132.40	26	35.41	CHANGED	PNspYps....sGh....hY.pTDphGRlspspu..pLp..L.h.t..p......scR.NsapQsss..Gp..........s...th.t....Dc.GGHLIustFsGssc.h.cNLVshspp.lNc......GpahphEpcWAs..ulpps..+pV.plcIpPlYpGs.S..RPssFplp.YpIss	...............................................................................t.................hh..phDphsRhttsps.....ht......h........p.................ttR...t.s.h......t...pss......uhh.t......................t.....tp.......tt.h..................h....s....RuH..LI......u........hp..h...............u...............G........p..............ss.....p..c.....NLsstoph.lNp...................sshhh....aE....sp....lpp...........shcps.....ppV...pYcls.PlYp.Gs..p...Lhspthplp.h.....................................	0	44	92	135
+13773	PF13931	Microtub_bind		Kinesin-associated microtubule-binding	Eberhardt R	re3	Jackhmmer:P46863	Family	This domain binds to micotubules [1,2].	25.00	25.00	25.60	25.60	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.08	0.71	-4.04	11	156	2011-04-08 14:37:49	2011-04-08 15:37:49	1	3	133	0	105	156	0	99.50	31	9.52	CHANGED	-LKh.hPTGTTPpR+casYP+sLstTpP+-pIlcRa+pEQshsp.hshsssIsEhscE-ss....pslpulpt.clpsoEslhsspsh.-hs-ssppttth..hQ.ppstsKttpsps.ps.lcp.psp.sppppu..........ls+ShhP.+tss	.....Lpp.hPTG.sTPp++pYtYPssLsRTcPH-pLlp.ph+...ppp.....................................................................................................................................................................................................................................................	0	23	39	72
+13774	PF13932	GIDA_assoc_3		GidA associated domain 3	Punta M	mp13	Jackhmmer:D0LLL5	Domain	The GidA associated domain 3 is a motif that has been identified at the C-terminus of protein GidA. It consists of 4 helices, the last three being rather short and forming small bundle at the top end of the first longer one. It is here named helical domain 3 because in GidA it is preceded by two other C-terminal helical domain (based on crystal structures [1,2]). GidA is an tRNA modification enzyme found in bacteria and mitochondrial. Based on mutational analysis this domain has been suggested to be implicated in binding of the D-stem of tRNA [2] and to be responsible for the interaction with protein MnmE [1]. Structures of GidA in complex with either tRNA or MnmE are missing. Reported to bind to Pfam family MnmE, Pfam:PF12631.	27.00	27.00	30.60	29.20	26.20	24.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.16	0.72	-3.92	60	4262	2011-04-08 14:57:33	2011-04-08 15:57:33	1	15	4143	17	1037	3177	2191	71.90	46	11.44	CHANGED	lKYpGYIcRQpppl.c+hc+hEshplPpclDYsplpuLSpEu+cKLscl+PpTlGQAuRIsGVoPADIolLll	...............lKYpGYIp+Qpppl.-+hc.+hEspplPtslD..Y..s..p..l..s..G..L..SsEsppKLpch+PtoIGQASRISGVoPAsISlLll...................	0	354	654	866
+13775	PF13933	HRXXH		Putative peptidase family	Bateman A	agb	Jackhmmer:Q5A0Y5	Domain	This family of putative peptidases are closely related to the M35 family Pfam:PF02102. In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these proteins is unknown. Members of this family are found to be fungal allergens.	21.40	21.40	21.40	21.40	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.70	0.70	-4.96	28	85	2012-10-03 04:41:15	2011-04-08 16:09:36	1	3	72	0	60	112	0	225.10	40	80.13	CHANGED	hhlllhsusshAussss.............tspsssssssshsWsuuh.....................sssFP.IHpSCNuTppcQLpsGLpEshpLAsHA+-HlLRaGspSpha+KYFGs.........usou-slGha-pll...........................suDKushLFRCDDPDGNCs..ss.WAGHWRGpNATsETVICDLSYp..oR+.LsplCutGYTVusussNsaWAsDLLHRlaHlPslG.pGhl-Ha....A-sY--VLcLAcs.NuohAlRsS-oLpYFAlDVYAaDlAlPGhGCsGc	.................................................h.hhh..............................t....ts..shshpt.sh.....................htsaP.IHpSC.Ns.T.ppp..LptuLp-shplAt+A+-Hl.......LcaG.scSth.a++YFGs.........usshpsl..G.ha-pls...........................susK....u.shLFRCDDs...Ds..sC......t.pss...aAGH.WRGpNAo.sETV..IC-lSYp..oR+sLsslCs.....tGaTVu.s.utss.paa..usDLL....HRhhHlP....slu..cuhVcHa....A-..sYp-llcLAps.Nsohus+socsLpYaAhDVYuaDlulPG.GCsGc...............................................................	0	13	30	53
+13776	PF13934	ELYS		Nuclear pore complex assembly	Wood V, Coggill P	pcc	Jackhmmer:O94384	Family	ELYS (embryonic large molecule derived from yolk sac) is conserved from fungi such Aspergillus nidulans and Schizosaccharomyces pombe to human [1]. It is important for the assembly of the nuclear pore complex [2].	27.00	27.00	27.30	27.00	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.63	0.70	-4.62	41	211	2011-04-11 16:17:10	2011-04-11 17:17:10	1	6	177	0	151	221	1	232.90	25	21.47	CHANGED	spLalDcLLpt....h....ul..............................ps.spthYPPco...L+s.Lhchllssss.....st..p..pKpullhYlLhDh.....cpt..............................phsppFupphtlscphhhhlcuhWhLD+...h-...acpAlchL..scP....ulh.....ssassc....IlpsLhp...............p.tsss...lAhtahpsssPslsos.............pslphhhsh.LspsslsEAFtatRphss...cpt...................p.hhEpllpaslp.t....................p.s.pp.h..hc.LlsLPhsppEEphlpc.h.......Lc...psspp....h.......sc-sllh	.......................................................................hLhlDtllpt....l.....sl.......................................ps.stthYPPpo...L+s.Lhphhh.....s.sh.......................sp....t.....tKpul...hhYlLhDh.......pts...............................p.hppFspshsls.phhhhhpGhWhLD+................t-.........................appAlchL.....scP.....uhh.........sphtsc....IlpsLhp........................p.tctp...hALtYhps..spPslsos...................................pslphhhsh...Ltp....s...slsEAahatRptss....ph.......................hcpLlphhhptpt.....................c.ttt.hpcLlpLPasspE-chlpc.hLp....sssth........spphlhh............................................	0	41	75	118
+13777	PF13935	Ead_Ea22		Ead/Ea22-like protein	Bateman A	agb	Jackhmmer:B2PIW3	Family	This family contains phage proteins and bacterial proteins that are likely to represent integrated phage proteins. This family includes the Lambda phage Ea22 early protein as well as the Bacteriophage P22 Ead protein.	27.00	27.00	27.10	27.50	26.10	26.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-11.18	0.71	-3.85	41	775	2011-04-12 10:52:06	2011-04-12 11:52:06	1	2	384	0	12	500	1	137.90	35	66.99	CHANGED	SpIsp..QALRE......sAcpAttu..h.......h.hh.t.t.t...h............................t...........................pspalst...h...s....PpslLALLDEhEp.......tpphlcthc.........s.cls.shsphpp.....cLcstcph...........................................................................................t.t..hp..hst.t.......RlA-L.E	............................................................ScIsY..QALRE......sAEp...Ahpupah.......h.hh.sppt.h...............................thhcp.hpth........................ssspFlshs...s....PssVLALLDEpE+................................sQphIcch-pc..............Np-lALs...lsKLRs.......-LEsscpph............................................................................................p.t....t................................................................................................................................................................	0	1	1	5
+13778	PF13936	HTH_38		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:B2PKW2	Domain	This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.94	0.72	-4.40	170	4579	2012-10-04 14:01:12	2011-04-12 12:55:48	1	55	1701	4	685	4174	318	42.50	36	15.56	CHANGED	phppLohpERtp....Ip.th...h.p...pG.hShp...p.IAcpLs+ssSTIuREl+Rs	......................ppLThpp.Rhp...........Ip..th............h.p.......pG.hS.R...p.IActLG+u.sTIpREl+Rs........	0	188	368	496
+13779	PF13937	DUF4212		Domain of unknown function (DUF4212)	Punta M	mp13	Jackhammer:D0LH74	Family	This family includes several putative integral membrane proteins.	30.00	30.00	33.60	32.20	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.63	0.72	-3.98	71	560	2011-04-12 12:23:16	2011-04-12 13:23:16	1	4	541	0	211	473	1169	80.10	43	74.54	CHANGED	pptptYW+pNl+LlhhLLsIWFlVSFG..hsll..hscsLsplp..l..hGasLGFWhApQGuIhlFllLIahYuhtMs+LD+caslcE	........c.ttpsYW+pNlp.llhsLLslWFl.VSFG...suIL...h........s........cs.......L......sp.lp...h......uGa.sLGFWFAQQGSIhsFlsLIFlYshpMsp.LD+caslpc.................	0	53	136	183
+13780	PF13938	DUF4213		Domain of unknown function (DUF4213)	Eberhardt R	re3	COG2014	Family	This domain of unknown function has an enolase N-terminal domain-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the N-terminus of proteins containing DUF364, Pfam:PF04016.	23.50	23.50	23.80	27.90	22.60	23.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.83	0.72	-3.85	59	215	2011-04-12 12:28:01	2011-04-12 13:28:01	1	4	184	6	124	217	9	86.60	23	32.70	CHANGED	lh-tlhpt....hp.shplcclslGlt..aTsVphspt.thGlA..hT.hpsh............h..h.hsup..ltGpsspclhphhh..uhs.slcpulGlAslNAlhp	....................hctlhpt....hp..shplpchshGht..aohVpss..s..t...uhGlu..hThhppt.................th....h.hssp..lt.Gpslc..clsphht..Shs..lctolGlAslNAl.....	0	51	88	108
+13781	PF13939	TisB_toxin		Toxin TisB, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:A5A627	Family	TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide. It is a hydrophobic membrane-spanning protein which inhibits cell growth [1]. Its expression is inhibited by the antisense RNA IstR-1, which acts as an antitoxin [2].	27.00	27.00	55.50	55.40	14.00	13.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.61	0.72	-7.09	0.72	-4.19	2	56	2011-04-12 12:59:00	2011-04-12 13:59:00	1	1	56	0	3	12	0	28.00	89	94.00	CHANGED	MushDIhILILKLhVAsLQLLDAVLK.h	MSLVDIsILILKLIVAALQLLDAVLKYL.	0	1	1	3
+13782	PF13940	Ldr_toxin		Toxin Ldr, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:E8XFD8	Family	This family includes the Ldr (long direct repeat) toxins. In Escherichia coli there are four Ldr toxins, LdrA, LdrB, LdrC and LdrD. These toxins inhibit cell growth, decrease cell viability and cause nucleoid condensation. LdrD expression is inhibited by the antisense RNA RdlD, which functions as an antitoxin [1].	27.00	27.00	39.60	39.30	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.68	0.72	-4.18	5	958	2011-04-12 13:02:29	2011-04-12 14:02:29	1	1	369	0	11	214	1	34.90	74	70.82	CHANGED	MTLsQLGlAFWHDLAAPlIAGIIAulIVNWLRcRK	..MTLApLuMsFWHDLAAPllAGIlsuhIVsWhppRK....	0	3	3	5
+13783	PF13941	MutL		MutL protein	Bateman A	agb	Jackhmmer:B2PG71	Family	This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family [2].	27.00	27.00	27.00	29.30	26.90	25.60	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.20	0.70	-6.16	38	371	2012-10-02 23:34:14	2011-04-12 14:12:58	1	3	341	0	69	264	97	432.00	39	94.36	CHANGED	slLssDlGSThT+sshh-...ssphcllupupuPTTV..t.tDVshGlppAlpclpcph....................shts..hshsphhuoSSAAGGL+MslhGLV.chTscAA+cAALuAGAplhpshuh.................clscpclcclpplpPDlILLuGGsDGGspcsllpNAchlu.ph........shshP......lIYAGNpsspcclpcILt..tsptslhls-NVhPcl-plNlpPsRcsIpclFhc+Ih.cA.Ghsc.lpchs......stslhPTPuAVhpsschluc.......thGsllslDlGGATTDlaSls....cst.t..thhhp...-PhsKRTVEGDLGhthustsllcthu...ttlhchhs.....tth.ptlpphhtpsshlPp.sc-Ethh-ptLAptAlphAlcRHsGphpplhsshtphh..ht.G+DLs........plchllGoGGsLs+usp..spplLpthhps.tt....lhPspp.....sclhlDppYlhuuhGlLup.htP-sAhplhccslth	...................................................................p.hlsl-IGSThTKsshFp...ss..thp...........hlupuhsPTTl..t...tclthGhpsAlspltpts...................s........shsphhssSSAuGGL+hsshGLs.shTscAA+cAAhuAGAplttshuh...................................pls.cpDlpp.l.p.cspP-IlLl..sGGsD.s...G-cchslpNA.+hlA.pu...............pL.s.ss...............llYAGNpclpccVpcIhs.....t.tpslshl-NVhPclDhlsltss.RpsIp-lF.c+Is.pu.Ghcs.l.h-hs......s..cplhPTPtAVhpsschlup.......uhs-hlllDlGGATTDVaSss...........tusst.sshllc....PEPhsKRTVEGDLGhhVsAhslsctssc......h....ht.................t.hcchhtp.chlPt..spcEt.hhsphLAt.sVthAspRHAGshpplhTssGps........lthG+DLo........sV+hVlGoGGhLo+sst...htclL+hhph..ssssp.....lL.ssc...................sphhlDpcYlhuulGslAp.s.PptAh+hhtphh..h.......................................................................................................	1	39	56	65
+13784	PF13942	Lipoprotein_20		YfhG lipoprotein	Bateman A	agb	Jackhmmer:B2PEB8	Family	This family includes the YfhG protein from E. coli Swiss:P0AD44. Members of this family have an N-terminal lipoprotein attachment site. The members of this family are functionally uncharacterized.	27.00	27.00	56.70	30.30	25.20	21.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.06	0.71	-4.74	26	543	2011-04-12 15:31:32	2011-04-12 16:31:32	1	2	534	0	41	227	3	177.70	71	74.12	CHANGED	lPcpplsDYRhssCcslWslpstsu.sNsLYWLRshDCA-RLssspARspA+pls...sssWpsuF+puILLssAchTssERRphlspLssaShphPsslRPLhQLWR-pQsLplsLuEERtRYp+LQpsoDucLDpLRppps+LptpLpsToRKLENLTDIERQLSoRKpst....sphs-sscss	.....l.PhYQLADYLoTcCuDIWuLpGKuTETNPLYWLRAMDCADRLMPAQSRpQARpas...DsoWQNsFKQGILLADAKITPhERRQlVuRl-ALSspIPAQVRPLYQLWRDGQALQLQLAEERQRYSKLQQoSDSELDTLRQQppsLQpQLELTTRKLENLTDIERQLSTRKPAGNasPDTPHps...........	0	1	9	24
+13785	PF13943	WPP		WPP domain	Woodcraft BJ	agb	Woodcraft BJ	Domain	\N	20.10	20.10	22.40	24.20	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.24	0.72	-3.80	25	109	2011-04-14 10:02:01	2011-04-14 11:02:01	1	14	29	0	65	111	2	95.70	43	27.43	CHANGED	Sl+lWPPoQpTRchlVcRhscsLoo..sSIlS++..YGsLsc-EApcsA+pIE-tAFusAsp.....thssps-sDGhpslQlYuKEsSKhMLEslKptspspssspss	..............ShplWPPoppTRphlVcRhspsLos..sSlho++..YGslsppEAccsA+tIE-tAFusAsp......thpt..psssDGhpslQlYuKEsS+hhLEhlKptststtt...ss................................	2	10	39	50
+13786	PF13944	Lipocalin_6		Lipocalin-like domain	Coggill P	pcc	Jackhmmer:JCSG_Target393211_GS13544C	Domain	\N	27.00	27.00	27.40	27.10	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.86	0.71	-4.00	21	111	2012-10-03 08:47:39	2011-04-14 14:22:19	1	6	70	1	13	99	0	127.70	22	39.62	CHANGED	clAGsYpGshslolss...sssshsos....ps...pplpIspss-sTlplplsshs.hth...G..lslGchsVsssslcpsssuhhp.hs.ssshp........scspss...............shss.olsGTl.psGshslshshc....s.Gu...hshslpssas	.............plsGsYpGshs.lslss....ssssht.s....hspplplsp.sscss...lplpLpsFsh........G...hplG-lsls.slsVppssss....thh..hs.tpshp.......hpspss...............shss.olsG..Tl..psuphshsls...lp.....sss.......hshslpssa.....................................................................................	0	7	10	13
+13787	PF13945	NST1		Salt tolerance down-regulator	Wood V, Coggill P	pcc	Jackhmmer:Q09863	Family	NST1 is a family of proteins that seem to be involved, directly or indirectly, in the salt sensitivity of some cellular functions in yeast. It does this without affecting sodium accumulation. It negatively affects salt-tolerance through an interaction with the splicing factor Msl1p. This interaction stresses the importance of efficient RNA processing under salt stress conditions [1].	20.00	20.00	20.60	21.70	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.31	0.71	-4.22	7	142	2011-04-14 14:53:59	2011-04-14 15:53:59	1	5	122	0	112	155	0	154.10	34	13.95	CHANGED	hDDpsp..hpspupp.ppphs...ts.hps.ssoKpKKKKKK+p+.upusShpssspps...s.STsps....ts..sLs...........psuh+.hpccc.IWsTSopEEREpI+EFWLpLuE-ERRSLVKVEKEAVL+KMKEQQKHSCSCoVCGRKRsAIEEELEVLYDAYYEELEQYANh.Qsshpsusslssssp	......................................................................spt........................................tttptppt.c...........t.....tt......t......t.....s..t.t............................t............................s..s.........................ps.t...hsppp..IW.s..oSop.E.....ERE......pI+cFWLsLuE-ER+sLVKlEK-uVL+KM.KE......Q....Q..+...............H...........o...........CSCoVCGRK.Rs.....AIEEELEsLYDuYY-.ELE.paApt.................t.................	0	35	64	99
+13788	PF13946	DUF4214		Domain of unknown function (DUF4214)	Coggill P	pcc	Pfam-B_781 (release 24.0)	Domain	This domain is found on a variety of different proteins including transferases, and allergen V5/Tpx-1 related proteins.	23.00	23.00	23.00	23.00	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.25	0.72	-4.29	15	574	2011-04-15 12:34:27	2011-04-15 13:34:27	1	75	127	0	119	497	104	67.10	22	14.25	CHANGED	VApoFluSsEFpp+YGs.slsscsaVssLYpNlLGRcuDtuGhsYWsupLssGsETRtElLLGFu-SsENcuLFoE	.......................................................pppal...p..plYpsll..sR...s..s..DtpGhpa.W.......h....s.......pL..p.....sG.t......o.......ht...phhh...th...h.pStEh.t....t....................................	0	33	86	99
+13789	PF13947	GUB_WAK_bind		Wall-associated receptor kinase galacturonan-binding	Coggill P	pcc	Jachmmer:Q8H7G7	Domain	This cysteine-rich GUB_WAK_bind domain is the extracellular part of this serine/threonine kinase that binds to the cell-wall pectins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.98	0.72	-3.48	243	1199	2011-04-15 14:01:02	2011-04-15 15:01:02	1	68	22	0	725	1166	0	107.00	22	20.37	CHANGED	hssC.s....s..p..C..Gs..l..s.IPYPFGI........G..s...s.....Chh......tuFp..lsC....ss...o.......s.st..lh.............tsshcVhs.IS.lt....p..........uplp....lhs.....sl....stpChs.sss.s...ph.......t.....sh..shst........s...........ahhSs.spNp.hssl.GCss	....................h..sC..s..p...p...C..G..s........l..s..IsYPF....G.l................s....s....s...........Csh............sFp...lsC....sss.........ts.st.lhh...............................ssshpV.hs....Is.....ht.....s....................sp...lp.lhs..........sh.....tt.shs..ssst............................hshsh.............s...................hh.h....s.t.p...N......h.h.hh.uCt..................................................................	0	34	326	531
+13790	PF13948	DUF4215		Domain of unknown function (DUF4215)	Punta M	mp13	Jackhammer:D0LZ65	Family	The function of this family is unknown.	27.00	21.50	27.00	21.50	26.90	21.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.30	0.72	-3.74	207	1195	2011-04-15 14:50:47	2011-04-15 15:50:47	1	70	35	0	1101	1185	279	46.50	39	15.77	CHANGED	ChpC...p..p..G..ap.h..s......pptC........hshC....GDslls.......sp.....EpCD.Ds.......Ntht..h.D.....GC....hp......Cp	.......................................C...........G..a..h...............tt...C..............hshCGDGlls...........st......EpCD..DG............Nphs..t.D......GC......p.....Cp............................	0	1023	1028	1080
+13791	PF13949	ALIX_LYPXL_bnd		ALIX V-shaped domain binding to HIV 	Coggill P	pcc	[1] 	Domain	The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, Pfam:PF03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.	27.90	27.90	28.00	28.80	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.74	0.70	-5.45	97	602	2011-04-15 15:01:10	2011-04-15 16:01:10	1	17	285	9	420	611	2	282.60	22	30.37	CHANGED	lc.s.s.......slPt..slh..c.csppl...p.pp.su.........lpplppthpplp..plpppspphlscsp.chLctEppp-pphRppa.sp..pWs+......sSsph...ss..plppclpchcphlpp.AspoDsplppphcp..hppsl..plLststpp.................................l.pshl.Ps.s.p...t...........................ts....p.s.........pp....tltpL+p.hlpclpplcpcRpp..hhp.cL+.p...th.p..sD.hhsplL..t...hsp......ptt...........s.p.h..c.tlFppcLc+.acshpppl.ppshppQppllpplpps..ppph......h...p.t.+.......ps..ptps.......ppRpphl....pplp.sua.ptap-lhsslpcGpcFYssLtphlp.phpppspsastsR+tEt	....................................................................................................tlP..slh...pchttlp...pp..ss..............hppltp.hppltphhppspphLpc...........st...chLptEptp-pphRtpa.sp...pWpp.........................sSsph.....sp...plpp..c...hpcacphlpp.Asp.....uDsplppphpp..pp...ssl.....plLsts.pp..................................................l.ps..tl.Ps.s.p....t.................................ts...ps.......pt............ltpL+p.hlpclppl...cpcRpp..l.ppL+.p...th.p.pD..hsp.hL.h...h.tp..tst.....................s.p.....c.tlFppcLc+.aps.hpp.tl.ppshppQppllpplpps..tpph..........h...p..+.............ps..ptpt.......ppRppsl.............................ppLt.sua.ptap-lhsslp..cGpc.FYscLtphls.phpppspshs.sRctE....................................	0	137	221	346
+13792	PF13950	Epimerase_Csub		UDP-glucose 4-epimerase C-term subunit	Coggill P	pcc	Jackhmmer:Q3EAY3	Domain	This domain is the very C-terminal subunit of UDP-glucose 4-epimerase.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.17	0.72	-4.03	308	5379	2011-04-15 15:23:58	2011-04-15 16:23:58	1	13	3888	48	1359	4059	1160	61.00	38	18.14	CHANGED	AFE+AsG+plPYclssRRsGDl...ApsaADss+Apc-LGWcAp+.sL--MCpDsW+WQspNPsGY	.....................shc+soG+slP.h.c..l.s.s..R..RsGDh...ushhAss..sKAcccLGWc.sph.sl.-c.......hhpc..u..Wp.W....p..p...ppPpGa............	0	444	849	1142
+13794	PF13952	DUF4216		Domain of unknown function (DUF4216)	Coggill P	pcc	Jackhmmer:Q9LI66	Domain	This DUF is sometimes found at the C-terminal end of proteins carrying a Transposase_21 domain, Pfam:PF02992.	27.00	27.00	27.50	27.60	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.46	0.72	-4.50	55	725	2011-04-15 16:13:17	2011-04-15 17:13:17	1	77	16	0	338	760	0	76.00	44	8.30	CHANGED	lclpa....c.sttph......p.lsLF+CcWhcs.p..spsl+hD.chG.hspVshsphhh.....cc.-PFlLAsQssQVaYltcPp........ppsWplVh	.....................................a..-.sYssh..+VPLF+CpWVcl....p...ssGVhlD.-tG.hTsVDLsKlGY.........pDEPFVLAspVsQVFYVcD.s.............h....h..............	0	0	50	68
+13795	PF13953	PapC_C		PapC C-terminal domain	Bateman A	agb	Bateman A	Domain	The PapC C-terminal domain is a structural domain found at the C-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the C-terminal domain from PapC and its homologues. This domain has a beta-sandwich structure similar to the plug domain of PapC [2].	27.00	27.00	27.00	27.10	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.26	0.72	-4.33	301	5978	2011-04-18 16:06:12	2011-04-18 17:06:12	1	11	820	10	369	3683	29	67.20	28	8.66	CHANGED	hslp.tsGp.slPFGAp...V.............p.......s....p.........p.s..p........p...s.....G.lVGpsGplY..lsGls..s.pupL.pVpW..Gss...ppCplsas.....lstppp	..........lp.tsGp.slPFGAp......V.............p........s..p...........p.s..p............s..s.....G.lVu-sGplY..LsG.ls..t..supl.pVpW..Gpp....stpCplsap..hs....p............	0	32	99	245
+13796	PF13954	PapC_N		PapC N-terminal domain	Bateman A	agb	Bateman A	Domain	The PapC N-terminal domain is a structural domain found at the N-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the N-terminal domain from PapC and its homologues. This domain is involved in substrate binding [2].	27.00	27.00	27.60	27.40	26.90	26.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.90	0.71	-4.63	34	5788	2011-04-18 16:06:36	2011-04-18 17:06:36	1	9	775	12	327	3635	16	143.60	29	18.18	CHANGED	hpFssshLpss.....tss.DlShFpps.tthhPGpYhVDlhlNsphhs..ptplpFpstsst........h.sCLop-hLpphGlphcths...tht.ptsp.........tChs..hstlPtsshpaDhup.tpLslslPQshLt.pscshhsPppWDpGIsAhhlsYshsus	.........................FssphLpss......tpsh...D...L.S...p.Fpps...sth.PGpYp.VDlhlNsphhs..ppsl.pF.h.ssssp......................thhsClo...p.Lp.p.hGl..p...s.ss.h.s....t...ht...ttss..............................tCls....hph...l.ss.ushp..aD.h.up..pLslol.PQshlp.p.p.s.c.s..alsPppWDcGIs.AhhlsYshsu...............................	0	24	83	222
+13797	PF13955	Fst_toxin		Toxin Fst, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:Q9RLG7	Domain	Fst (faecalis plasmid stabilization toxin), also known as RNA I, is a toxic peptide. Its N-terminus forms a transmembrane alpha helix, its C terminus is disordered and is likely to be cytosolic. Its translation is inhibited by the antisense RNA, RNA II, which acts as an antitoxin [1,2].	36.00	36.00	36.20	36.30	31.90	35.70	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.50	0.72	-6.41	0.72	-4.17	13	45	2011-04-19 12:12:39	2011-04-19 13:12:39	1	1	41	1	5	25	0	21.00	62	62.92	CHANGED	FspIIAPllVGlllpLlc+WL	.hpTIIuPIVVGVVLcllD+WL	0	0	1	2
+13798	PF13956	Ibs_toxin		Toxin Ibs, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:C1P607	Family	The Ibs (induction brings stasis) proteins are a family of toxic peptides. Their expression is inhibited by the Sib antisense RNAs, which act as antitoxins [1].	27.00	27.00	33.30	33.00	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.06	0.72	-6.46	0.72	-4.07	4	33	2011-04-19 12:16:39	2011-04-19 13:16:39	1	1	15	0	5	21	0	18.80	77	64.41	CHANGED	MMKLVIILVVLLlISFsAY	MMKlVIILlVLLLISFsAY	0	5	5	5
+13799	PF13957	YafO_toxin		Toxin YafO, type II toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:Q47157	Family	YafO is a toxin which inhibits protein synthesis. It acts as a ribosome-dependent mRNA interferase. It forms part of a type II toxin-antitoxin system, where the YafN protein acts as an antitoxin [1,2]. This domain forms complexes with yafN antitoxins containing Pfam:PF02604.	25.00	25.00	28.40	28.20	22.70	20.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.48	0.72	-4.24	20	200	2011-04-19 12:19:10	2011-04-19 13:19:10	1	1	179	0	23	81	1	104.50	53	80.37	CHANGED	athacpsGs.hs...shhG+Dshaccs...sphh.sclpHlHlt..............t.pssW......h.phhQhpRTSD.saLVYs.thhssppahlluIl.cPsAHcps.......cppsh.hspltchAEpFppph	...........FISYKRDGV.LP...DIFGRDALYDDSF.TWPLIKFERVAHIHLA..................NsNNPFP..........PQLRQFSRTNDtuHLVYC..Q.GAF...DEQAWLLIAIL.KPEPHKLA........RDNNQ.MHKIGKMAEAFRMRF..............	0	7	13	17
+13800	PF13958	ToxN_toxin		Toxin ToxN, type III toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:B8X8Z0	Family	ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI [1,2]. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex [2].	25.00	25.00	25.40	25.40	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.03	0.71	-4.57	31	151	2011-04-19 12:21:31	2011-04-19 13:21:31	1	2	115	10	9	140	2	147.30	27	88.43	CHANGED	hclYpIsscYlsYL+ch.....Ds.+Vh.st...ppppRsalGlllplsshcYasPLSSPKpK+cp....................hcppl......shhKIpp.......phLGllplNNMIPV.-sp..lphlDlp......p.p-p+....Y+pLL.cphpalpp..spccItc+.AcplYpphhppt.............tlpptsssFplLEctsppY	......................phYplspcYlphLpph.....Dp......+V..s......tpp.+salGlll.p.l.s....shpYhsP.loSsKp.K+cp.....................................hp..sph......shhKl.p...........phluslplspMIPVscst...hptlshp..........p.pD..+....Yp..pLltpphpalpp......ppppI.hpp.upplYpphhppt.............hhpphsssFthLEchh.t...............	0	3	5	6
+13801	PF13959	DUF4217		Domain of unknown function (DUF4217)	Coggill P	pcc	Jackhmmer:Q1KS87	Domain	This short domain is found at the C-terminus of many helicase proteins.	27.00	27.00	27.30	27.50	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.03	0.72	-4.43	193	1332	2011-04-19 13:16:38	2011-04-19 14:16:38	1	18	316	0	937	1323	22	64.00	30	9.61	CHANGED	slppp.........l........cp.hlhpc.pltphAp+.........AFhSalRuYtpH..pt+.......pIF.plppL..clspl...AcuaGLhpsPphp..t	.......................lptplcp..hlhp.shtlpp..tAp+.........AFhS..........al+uYspH..ph+...............plF.pl..p..pL..cLscl.............A.pSaGLhpsP+h..................	0	329	530	778
+13802	PF13960	DUF4218		Domain of unknown function (DUF4218)	Coggill P	pcc	Jackhmmer:Q9M233	Domain	\N	27.00	27.00	27.20	27.30	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.50	0.71	-4.70	38	847	2011-04-19 13:36:45	2011-04-19 14:36:45	1	90	37	0	424	907	0	109.80	46	12.19	CHANGED	tsIscLshFFptlspKVl-sppLcpLpspll.sL..CpLEhhFPPSFFDlMhHLhlHLVcEs+lsGPlahR.MaPaERaMthLKuYVRNRA+PEGSIsEuYhsEEslEF....CscYhp-ss.sluh....sss+pcsph	................................................t.sl.cls.F.hptlsp.KllcsppLptLpspllpsL..s.p.h..EhhFPPoFFslMhHLh....sH...LVcp.hplhGPhah+pMaP.aE.RY.Mu.lLKpYVRNRA+.PEuSIscu.YsTEEslE....F....Cs-alp-hp.sIGlPtsR+-spl............................................	0	21	99	119
+13803	PF13961	DUF4219		Domain of unknown function (DUF4219)	Coggill P	pcc	Jackhmmer:Q9C740	Domain	This domain is very short and is found at the N-terminal of many Gag-pol polyprotein and related proteins. There is a highly conserved YxxWxxxM sequence motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.21	0.72	-4.46	162	657	2012-10-02 13:37:57	2011-04-19 14:55:30	1	109	61	0	341	681	0	27.50	37	3.68	CHANGED	hsu.sNYshWsh+McshLpupc..lW.csV-	....hsG.sNYstWsh+MpsaLpupc.....lW.csVp.......	0	83	169	206
+13804	PF13962	PGG		Domain of unknown function	Coggill P	pcc	Jackhmmer:B9DG91	Domain	The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.	23.00	23.00	23.10	23.80	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.62	0.71	-4.46	259	1615	2011-04-19 16:12:26	2011-04-19 17:12:26	1	118	27	0	955	1566	0	108.80	26	29.59	CHANGED	pchhpctpphlhllAsLlATVTasAuhssPGGa..ps...................sGpslL...sph.tapsFhh.sNshAFssSlsslll..Ll....th................hpth..hhh..hhhhhhhlulh.ulhsAasuGshhs	....................p...hpctppslhllAsLlATVoa.sAuhssPGGh.htss.................................p.....p.sGpsllt....p........p...ta..tsF....hh.ssshAh....hsSlsslll..ll..t.th.........................pth...h..hhhhhhhhhhhshh.uhhsAahsu.hh.............................................................................	0	48	486	751
+13805	PF13963	Transpos_assoc		Transposase-associated domain	Coggill P	pcc	Jackhmmer:B3H612	Domain	\N	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.73	0.72	-3.99	127	878	2011-04-20 16:20:45	2011-04-20 17:20:45	1	73	23	0	549	900	0	68.40	41	9.37	CHANGED	RsWM..........thhop-ahcGlppFlphAhsphtppp.....pl.hCPCpcCpNthh...psp.pplppHLh.ppGF..hpsYph...WhpHGE	................................pWMY..........pRhop-ahcGVp.FlphApsptppt......hl.hCPCp.cC+Nph.....pss..cpl+tHLh.ppG.Fh.sYss...Ws.pHGE...........	0	1	262	285
+13806	PF13964	Kelch_6		Kelch motif	Coggill P	pcc	Jackhmmer:Q9CAE9	Repeat	\N	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.23	0.73	-8.85	0.73	-3.57	179	1811	2012-10-05 17:30:43	2011-04-20 17:50:05	1	393	387	0	1125	11207	344	52.00	22	10.77	CHANGED	hpt..ht.sh..ss..ss...s..t..l.alh..GGt.sp................sphhh.as.....p..o..p..p..ap.p...l..s.....s..h.....t....s...p	............h....tt.us...ss...hs.......s...c.....l.Ylh...GGh.ss................................thhsslht.ac....sp....o...p.....p.....Wp.p.....l...s......s...h.............................	0	462	599	827
+13807	PF13965	SID-1_RNA_chan		dsRNA-gated channel SID-1	Eberhardt R	re3	Jackhmmer:Q9GZC8	Family	This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps [1]. They are required for systemic RNA interference [2,3].	28.70	28.70	29.10	29.10	27.90	28.60	hmmbuild  -o /dev/null HMM SEED	570	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.15	0.70	-13.15	0.70	-6.34	8	320	2011-04-21 14:52:42	2011-04-21 15:52:42	1	5	81	0	179	283	11	382.50	32	77.38	CHANGED	SEPhaaahp.......shsp.sssoVhlclsS-Dsl.ChsVSlQsusCPVaDhspslp.sapGhapTho++uuIhlpKp-as..ttFhVFsVlps-DssCopps......pp.ps....sNcsK....oIoFplsh.hpshp...YtsholshlhhlhohhL..lahs.lshplhpspppht..............ptslluhpPs.sop.p...........p.hsh....tpcp.sspssshcEpc....hsspph..pllhs+tsLpVuDLu+csp..phlKp+ShsYhapllslulFYsLPVlQ.LVlTaQ+hlspT..GcpDhCYYNFhCA+PL....hhlSsFNplhSNlGYllhGlLFlllshpRchpa..........sppaGlPpHaGLaYAMGlALIMEGlhSAsYHlCPNpsNFQFDTSFMYVIssLsMlKlYQsRHPDlsuoAYssFulLuV.slLsulIGlhs+ss.hlallFslIallsshhlSh...............phYahGshKl............................csRhhl.Ls..........................h.slsNauhhshGL....ph+...stDFusalLhlFhsNslLYlsaYhlMKl........lspE+IshpAllhhhLAllsWssAuaFFhpcsosWTcoPApSRphNp.CllLcFYDsHDlWHhhSAlAlaFTFhhLhslDDDLhsshRssIsVF	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.....h...................s.s.......hhhh.G..h.hh....p.....................................sh.........hhh.hh..uh.us.hp.CP.s..shp.a........hh.h..hh..a..R.............p...............h.....h.......h.................h......................hh.h.h....h...h..h..hh....h.hs...........h.h....t.........................................................................................h.h...................................................h..hhsh.hhh.......h............t.....th....hhh.hh..h....phhhYhhhYhh.Kh.........................h.t.c....p..h........sh....h....hhhh..h......hh......u......hh..a........t.....th..............ssA.SR.hNt.C.h.th.h....D.+Dh.hHh.suhshhh..h.h..........................................................................................................................................................................................	0	78	96	140
+13808	PF13966	zf-RVT		zinc-binding in reverse transcriptase	Coggill P	pcc	Jackhmmer:P93281	Domain	This domain would appear to be a zinc-binding region of a putative reverse transcriptase.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.14	0.72	-3.67	117	1664	2011-04-21 16:16:41	2011-04-21 17:16:41	1	319	46	0	590	1605	0	79.10	24	12.48	CHANGED	pFSs+ssYph.l.pssss.ts...ap.pl......Whspsss.KhsFFsWhAshs+lhTtDpLp+...+.s.h..t..hs..spCh.LC.p.p.ppEohsHLhhpCshsp.tlW	.........................................ha...................................t..............t.ph..................Wp.t..p..s.P..K.lp.hF..h..W..h..h.hps.+..l........TtspLtc...+..s...h...t...hs......sh..C....h...C..t.t.tt.....EshpHlhh.pCshsttlW...........................................	0	51	342	453
+13809	PF13967	RSN1_TM		Late exocytosis, associated with Golgi transport 	Coggill P	pcc	Jackhmmer:Q39074	Family	This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localised to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface [1].	27.00	27.00	27.10	27.20	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.20	0.71	-4.67	177	1182	2011-04-26 11:55:49	2011-04-26 12:55:49	1	36	266	0	844	1140	1	153.80	22	17.75	CHANGED	slhsslshshsluhhhhhhFslL..Rhp.....hpclYt.PR....phht...........pppss....tuh........auWlsshhchs-ppllppsGLDAhlFLRah+hs.hplhhshsllshslLhPlN.......ss......ssttt.............................th.shhohuNl......psps...........thasallhsala....sh.hshahlhcE	................................................................................hhsshhhshhhhhhhhhhF........hL..R.p....................plYt.s+..........hhh..............................tptt.......puh...................................h.uWlhsh..hc.....h..s..-..ppllppsGlDAhhaLRah+h...........h.ltlhhshslls.....hslLlPlN................hs.............usthp.............................................................psh..spho.huNl.....psss.............................hhWsHslhualhhh.hshahlhp.....................................................	0	239	465	693
+13810	PF13968	DUF4220		Domain of unknown function (DUF4220)	Coggill P	pcc	Jackhmmer:Q9FHJ0	Family	This family is found in plants and is often associated with DUF294, Pfam:PF04578.	27.00	27.00	27.40	27.30	25.10	26.90	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.24	0.70	-5.35	29	828	2011-04-26 13:23:38	2011-04-26 14:23:38	1	24	16	0	517	735	0	247.10	18	46.39	CHANGED	LWlAYhhAD.lAsasLGhLohst.............sst.....pppLhsFWAPFLLLHLGG.DTITAa..ShEDNpLWhRHlLsLssQshhu...hYVhh+.ph...s..u..s.......lhsshlLhFlsGllKYuERs.hA...LptAuh.................pphtsphhp....tscssss.h....s.h......hhcph.t...h.p.tth.sph...hhh.t....................................pphsptphlhtAashhp.hhp.thas.s.hhh....s.........hpcp.ppst..th...hpph.......pt.........h.ppua+llElELuhhYDhLYTKsslla.............o.hhGhh....h....Rh........lolhsss.sAhhL......Fth............t.....spt........th.p..as....psDlhlTYlLLuGAllLElhullh.hlhSsWshshLpp...p......hh..hhs...............hhtthhphlph.................h...pp.R..WSsphuQYNLlptC.hcccs	...........................................................................................................................................................................................................................................hWs..h............h.s......t........................h.........h...hh.h........hh.hh.....h..............................................h....h.hh.h.shh.+..hh.+..h........h..st........................................................t..................................................................................................................................................................................................................................................h....t...................................................h...h.................................................................hh..plh...p.plsh.hh-hha.oth.hh..........................................h..h..h....h.................h...........h.hh...........h..........................................................................................t..h...l..s...hhhh.......hhh.-h....h....h....h.s...h...............................................................................................................................................................t.............................................................................................................	0	6	185	357
+13811	PF13969	Pab87_oct		Pab87 octamerisation domain	Punta M	mp13	pdb:2qmi	Domain	This domain was first characterised as the C-terminal domain of Pab87 serine protease from Pyrococcus abyssi [1]. The domain is reported to play a crucial role in Pab87 octamerisation and active site compartmentalisation. Its up-and-down 8-stranded beta-barrel 3D structure is reminiscent of the one found in lipocalins.	27.00	27.00	41.60	40.40	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.23	0.72	-3.90	6	15	2011-04-26 15:55:18	2011-04-26 16:55:18	1	2	14	8	11	15	0	95.70	34	22.07	CHANGED	Pc.ELPFhhREclL++LEGhYcGY+GTlcapVKscGDhLhL+shGth.pho.hsLhPE-lc........EDal+haTh..GtKh.VEFp......IcsscVcllaERY+LlK	.....Pc.ELPhlhhEchLc+LEGpYcuY+GTlchsVcscGDhLhl+utuchtpto.hsLhP--lc........-DascahTht.sGt+hsVEFp......hcsscVcLlhERa+LlK.	0	4	6	7
+13812	PF13970	DUF4221		Domain of unknown function (DUF4221)	Coggill P	pcc	JCSG_target-390208:A6KZ57	Family	This family of bacterial proteins contains highly conserved asparagine and cysteine residues.\	 The function is not known.	27.00	27.00	27.00	27.90	26.90	23.80	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.12	25	101	2011-04-27 09:58:51	2011-04-27 10:58:51	1	1	42	1	34	143	0	317.50	18	85.45	CHANGED	lhhlhll..hSCusp......pcpp.t.................pshsLh..ps...cslsaslD-psh..........hshslt.h..p...........psscchLh.Fhs..ptp...plphhDLcst.cllcpI.hccE.GPNGIspsh..uhh..s.Dshalh.ss..th.plhhhsppGphhpphsh...pssp..........pht.tphst..hh.....ssh.th.p-shlahs.h.......httc.hpphhs.hAhlDlpspplchhsl.sh.s.hhpp..ht.......phss.....s....h..s.....pssh...ph..ssspllhShssssplah.......s.s..p......tcphphh.pss..uphh.....spht....phpss....pps....hsp.hhc...ths.ppspYuslhaDch+chYaRaup......tsps.tpt.h..p.pphslhlaDc-asllGEsp	............................h.hhlhll..huCspp......pppt...................................................tphpL...tp...cslthsls-phh..........h.htl..h..p...........psuccaLh.h.s..php..tplp..hhDlpst.clhcpl.hcc-..GPsul.s.thh..uhh.hshDuhalh.st...........plhhhs.ppGclhpphsh...pptt...........ph....thss...........psh..hh.tsp.t.h.ahs..................h..t.p.h.ppphh..hshhshps.....pph.ph.hsh...h.s.hhpp...........phts.....s....h...th.....phsh...sh..ptspllhua.spsplal.....hs...p......tpph.chh.shp..Sphh......sph......ph.ss..tp....hpthhp.....hhppspYtslhYDph+plaaRhsh.sh......tstp.h...........p.+ths.lhlhDp-aplluEp..........................................	0	26	32	34
+13813	PF13971	Mei4	MEI4-Rec24;	Meiosis-specific protein Mei4	Wood V, Coggill P, Eberhardt R	pcc	Pfam-B_78600 (release 24.0)	Family	This family of meiosis specific proteins is required for correct meiotic chromosome segregation and recombination [1]. It is required for meiotic DNA double-strand break (DSB) formation [4].	21.70	21.70	23.20	23.50	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.51	7	42	2011-04-27 10:11:47	2011-04-27 11:11:47	1	1	32	0	25	34	1	302.40	31	94.28	CHANGED	Mssp..p.........hhpT........+lAlAlAII+p+PsshsuRpaoEhLtptlppp-psWKpcsctLctclhpl+QcL......L.sp.sss.h..t.t.h.tcl.sQpshpt.sstshhcphtssss.p.ps........................p.sphsh-s.hst+hpFLpplhcL+shp......pph..phplh...........psuhpplLssLhphh+ss+....Lh.sphhppsltslsphhsphshpphhstpppp+lp-hhppLlphlLpppplsphpsQchlsppLlsL.upss..h..lIphLLoplpshscsL.phh.pp...sh.p.tt.......phDssphpNhahhahllEpllppp..t..h.....p....pph.tph-cplh.hu-tFPLFuhhL......................WRlGslLsusc	......................................hh..........+lAlAhAII+o+PsshssRpasp.Lt.phlpt...p-.ph+pphcsLchcshph+pcl..........L.s+h.tst.h.......t.t........t.h.spp.hps.sshs.hc.-ssss.s.p.p................................chspsshppsLos+hpFLQ+lLpL+shp......csst.p.hpls.hp.p..ppl..s-SV.pLLDuLlsFa......+pPK....hshsphhpcAlpsLsphlsshshspthhKps.K+LEEhpcoLlphILpsppINphpstp.hsp.Lhhl.......h..llphlL..lpth.p.L.................................hp....hh.hhptl..t..........................p......ptash.th.h......................hhlt.h.................................................	0	6	10	14
+13814	PF13972	TetR		Bacterial transcriptional repressor	Coggill P	pcc	JCSG:Target_399142	Family	This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.  The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription [1].	25.00	25.00	25.60	25.40	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.64	0.71	-4.76	102	573	2011-04-27 11:46:47	2011-04-27 12:46:47	1	2	496	2	150	441	87	146.10	26	66.69	CHANGED	ppYppplpphhpssps....tt..........sl....-shhhYlcslFphhWpYRFhap-LsslLs+stpLppcapp.htpphhpphttlhpthtptGllp.hsspc.lp..sLspslhllsoaWlsapp..stpsptt....hsptsltpGl..hpllsLhtPalsspuppthp	..................................pYpppl.phLp.sps..pp..........sl--hhtYLpslhshhWcYRFlapD.LscLLsRst.cLppcapp.htpch.hpph.hslhpthhst..ullp..hs............psp.lp..sLspshhllsohWlsapp..shp..pst....lscptlppGl....hphlslltPalpspuRpth.............................	0	36	71	113
+13815	PF13973	DUF4222		Domain of unknown function (DUF4222)	Bateman A	agb	Jackhmmer:B2PP87	Domain	This short protein is likely to be of phage origin. For example it is found in the Swiss:B6DZ51 Enterobacteria phage YYZ-2008. It is largely found in enteric bacteria. The molecular function of this protein is unknown.	21.40	21.40	21.90	25.00	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.36	0.72	-4.56	30	595	2011-04-27 13:50:12	2011-04-27 14:50:12	1	1	284	0	13	250	0	52.30	37	64.10	CHANGED	shhphschY+D.ppGhhVplhussps..RVhahR.-GYpasCshPltpFpp-FphVp	.........hhphsphY+D.paGssVpIpplpcp..+VhYhR.-GY.a.sChhPlhpFpc-Fp.lp....	0	0	2	6
+13816	PF13974	YebO		YebO-like protein	Bateman A	agb	Jackhmmer:B2PQU2	Domain	This short protein is uncharacterized. It seems likely to be of phage origin as it is found in Swiss:Q9MCU2 and Swiss:Q9MCS4. The protein is also found in a variety of enteric bacteria.	27.00	27.00	30.70	30.60	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.82	0.72	-4.20	21	513	2011-04-27 13:58:43	2011-04-27 14:58:43	1	1	509	0	34	129	0	79.70	73	86.41	CHANGED	lslsllsllluLllWFFlNRASVRANEQIcLLcpll-QQKpQss.....LL.................p+Lspssp...tpst..s......custpssp.-atphIsER	...lVSlVVLLlGLILWFFlNRASSRsNEQIELLEALLDQQKRQNA.....LL.................RRLCEANE.....PEKscccss.......-S..pcusEDEDIIRLVAER..................	0	1	5	19
+13817	PF13975	gag-asp_proteas		gag-polyprotein putative aspartyl protease	Coggill P	pcc	Jackhmmer:B8H4J3	Domain	This family of putative aspartyl proteases is found pre-dominantly in retroviral proteins.	32.00	32.00	32.00	32.00	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.83	0.72	-4.15	40	832	2012-10-02 15:32:34	2011-04-27 16:57:49	1	76	77	0	189	1318	75	69.60	42	6.43	CHANGED	tshtptsphplpsplsu.hphp.sllDoGAots..hlspphAp+L.....uhshpths........hplp...hAsupstpspshhpshh	.......................h..hp-sGssTIoVhIGG..p.....hlc.pALLDLGASVN..LlPhslaKpL.....GLstLKsT................sloLp....LADpSl+hscGll-s..l..............................	0	53	73	124
+13818	PF13976	gag_pre-integrs		GAG-pre-integrase domain	Coggill P	pcc	Jackhmmer:Q8S892	Domain	This domain is found associated with retroviral insertion elements and lies just upstream of the integrase region on the polyproteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.52	0.72	-4.33	1103	1961	2011-04-27 16:15:09	2011-04-27 17:15:09	1	257	126	0	637	1866	6	69.40	23	6.66	CHANGED	sLYhl..sh..........p....p.h...s.s...........s...........s...s...........s.........s...........sp........p...s...........ss...shlWHpRLG.Hhuhp...tlpcLs..p..........th.....l...sth...s...h........p.....tp.......hCcsChhuKp	............................................................a.h................................t..................................h...........s...........h.................sp.........t....s..........................ss...shlWHpRLG.Hhuhp...tlpcLhp............pth......l......tsh...s...h............p.........tt.......hCpsC.huKp................................	0	184	260	364
+13819	PF13977	TetR_C_6		Bacterial transcriptional repressor	Coggill P	pcc	Jackhmmer:P17446	Domain	This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity [1]. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.28	0.71	-4.06	258	2956	2012-10-03 00:15:22	2011-04-27 17:17:06	1	10	1376	20	826	2207	181	109.00	18	54.34	CHANGED	P....ppRLpullcsshs..sthst..t...thps.WlsFaupu.hpss...phtclpphh.tpchcspLtthlp.....phhs.........stcscthAptlsAllDGL...alc.ssls.........tshs..hpput...plspphlsthls	.....................................................pthht...h...h...s....p.hs.......t..........shph...hh....phhut..u..h.+.pP....tl.t.pl....hp.tt....pchps.sL.s.phh.c.........pths............t...ps......p.....thu.ps....Ls....Ahl.-.Gl...hlc.hshs.......pshs....tpphh...phhpphlt....t.....................................	0	232	548	713
+13820	PF13978	DUF4223		Protein of unknown function (DUF4223)	Bateman A	agb	Jackhmmer:B2PGT1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. These proteins are likely to be lipoproteins (attachment site currently included in alignment).	27.00	27.00	43.80	43.80	25.90	21.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.85	0.72	-4.24	6	435	2011-04-27 16:27:16	2011-04-27 17:27:16	1	1	432	0	13	47	2	55.40	89	99.28	CHANGED	MpKhlKlAlluuVLo...oLTACTGHlpN+cKNCSYDYLLHPAISISKIIGGCGP....sApQ	........MNKFIKVALVGAVLA...TLTACTGHIENRDKNCSYDYLLHPAISISKIIGGCGP....TAQ..............	0	1	3	8
+13821	PF13979	SopA_C		SopA-like catalytic domain	Bateman A	agb	Jackhmmer:B2PGH8	Domain	This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes. This domain contains the active site cysteine residue.	25.00	25.00	25.70	32.90	19.10	24.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-10.90	0.71	-4.65	9	234	2011-04-28 08:31:54	2011-04-28 09:31:54	1	9	189	13	6	132	0	163.80	49	24.43	CHANGED	.hcscLcshFhpAhppspsplKhl--tpp.pcLtpla.ph...psh.ptapLpscHappIlshYsLsshocpcKAEILFsLusVFs+YSSSslFGsEhDSPphLRtYApALhpKAacLDPplh.opppFs-WpsRLlGpssuF....TC..TulLtspMhcHAcppFsslLpplhPsAWR	.............................................................t.p+GcLpptFluAhspK+SsVKhlsDss..o+LsolF............ss.hhsptpLs....stHYppILoua.....cLsDAo..pKQAEhLFCLSssFA+YSSSslFGTEaDSP.sLRtYApALhpKAacLsPulFsS......s...ppFs-apDRhp.Ghps.sF....TC..TSVlsDsM....pRH..A+c.hFPpVLSphhPlAWt...................	0	1	1	4
+13822	PF13980	UPF0370		Uncharacterised protein family (UPF0370)	Bateman A	agb	Jackhmmer:B2PE90	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DWP sequence motif.	27.00	27.00	27.90	63.70	24.00	23.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.21	0.72	-4.15	13	533	2011-04-28 08:38:11	2011-04-28 09:38:11	1	1	532	0	39	98	0	65.30	86	99.09	CHANGED	MpWL.ADYWWl.ILLlLlGlIlNuIK-LpRlDtK+FLcNKP-LPPHRDNNcpWDDED.DWPp..cKK+	.........MDWL.AKYWWILVlVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDD.D.D.DWPK..KD..QPKK.	0	1	8	23
+13823	PF13981	SopA		SopA-like central domain	Bateman A	agb	Jackhmmer:B2PGH8	Domain	This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes.	27.00	27.00	28.20	29.30	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.64	0.71	-4.14	14	461	2011-04-28 08:38:40	2011-04-28 09:38:40	1	13	337	13	6	257	0	135.00	39	23.85	CHANGED	splKschsccLlpsLspsplslsp..sh.s..LhsIhucssYlpsspIp.palpplp-sahpshsp..............hshhcppspllpshlshFs......+pP-hMlst..NusFIQhlhtshtpt..ssshpppAtcLYppYLphsplp.hhpps-	.............................................h...KshhshcLVhQL..phLshssh.phlEs..h+chhSHsPYIpsslI+.SaI+ssc-shF-shhppa...........Rhscssassp.h.tFlspFs......hNptLhspp..NshFIQlIspshcus..sDth+ppAhtLYcpalppscVSPhhhp.................	0	1	2	4
+13824	PF13982	YbfN		YbfN-like lipoprotein	Bateman A	agb	Jackhmmer:B2PG20	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. Members of this family are lipoproteins.	27.00	27.00	35.70	35.60	22.20	19.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.92	0.72	-3.80	7	463	2011-04-28 08:44:07	2011-04-28 09:44:07	1	1	455	0	19	107	1	88.00	88	81.76	CHANGED	QssAP.EDu+.LKpAYSACINsA-GSP-KltuCQuVLsVLKp-KtHQtFAppEoVRVLDYQpCIpAspTGNsQshsApCsKlWQEIRuNN	.............QSTAPQEDSR.LKEAYSACINTAQGSPEKIEACQSVLNVLKKEKQHQQFA-QESVRVLDYQQClpATQTGNDQAVKADCDKVWQEIRSNN................	0	1	3	9
+13825	PF13983	YsaB		YsaB-like lipoprotein	Bateman A	agb	Jackhmmer:B2PHF9	Family	This family of proteins is functionally uncharacterised. These proteins are related to E.coli YsaB Swiss:Q0TBP2. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. These proteins are lipoproteins.	27.00	27.00	27.00	32.00	22.20	22.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.67	0.72	-3.82	9	447	2011-04-28 08:46:45	2011-04-28 09:46:45	1	1	445	0	15	112	0	76.10	88	78.93	CHANGED	PsQKAQ+sKVSPpRoLsMEpLCK-QAA+RYNTssQKIDVTGFEQFQGSYEMRGpThRKEuFVCSFDA-GQFLHLSMR	.....PVQKAQRVKVDPLRSLNMEALCKDQAAKRYNTGEQKIDVTAFEQFQGSYEMRGYTFRKEQFVCSFDADGHFLHLSMR	0	1	1	8
+13826	PF13984	MsyB		MsyB protein	Bateman A	agb	Jackhmmer:B2PRZ7	Family	The MsyB protein has been found to be able to restore protein export defects caused by a temperature-sensitive secY or secA mutation [1]. However, its exact molecular function is still unknown, but it may play a role in protein export. Proteins in this family are approximately 120 amino acids in length. This family of proteins is found in bacteria.	27.00	27.00	68.40	68.30	25.00	18.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.48	0.71	-4.08	7	458	2011-04-28 08:52:19	2011-04-28 09:52:19	1	1	455	0	27	99	2	121.30	91	97.87	CHANGED	MYsTL-EAIDAAREEFLAsp.t.--D-ssV.sQFNLQKYVMQDGDIMWQAEFFtDEs-pGEClslhSGtAAQAIFDsDYDElElRpEW.sENTLHEWD-GEFQL-PPLDoEEGcAAAsEWD-c	.MYATLEEAIDAAREEFLADNPG.I.DAE-.ANV.QQFNuQKYVLQDGDIMWQVEFFADEGE.EGECLPMLSGEAAQSVFDGDYDEIEIRQEWQEENTLHEWDEGEFQLEPPLDTEEGRsAADEWDER.	0	1	3	15
+13827	PF13985	YbgS		YbgS-like protein	Bateman A	agb	Jackhmmer:B2PG89	Family	This family of proteins is functionally uncharacterised. The family includes the YbgS protein from E. coli Swiss:P0AAV6. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. Some members of this family are annotated as homeobox protein, but this annotation cannot be verified.	27.00	27.00	28.90	28.60	24.50	22.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.71	0.71	-4.22	9	467	2011-04-28 08:58:10	2011-04-28 09:58:10	1	1	463	0	22	92	0	123.50	85	98.29	CHANGED	MsKLAoLFLTAshoLASGAALAADosuposNGpANuAADAGtVAPsAKpNlAPNNVDNopINTsss.........Go.hpsss....ohspcsMopDElHKNoMCKDG+CPDhNKKVpsttu.ss-ssTKTDGTTQ	....MTKLATLFLTATLSLASGAALAA.DSG..AQ...oNNGQANAAADAGQVAPDAREN..VAPNNVDNNGVNTGSG....................GTM.LHsDG.......SSMNNDGMTKDEEHKNTMCKDGRCPDINKKVQTGDGINNDVDTKTDGTTQ...................................................	0	1	2	12
+13828	PF13986	DUF4224		Domain of unknown function (DUF4224)	Bateman A	agb	Jackhmmer:B2PT37	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. The protein is likely to be of phage origin and is found as protein Gp02 Swiss:C8CLF5 in the Xylella phage Xfas53 [1].	21.30	21.30	21.30	22.20	21.20	19.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.11	0.72	-4.41	38	290	2011-04-28 09:01:39	2011-04-28 10:01:39	1	2	222	0	30	167	2	46.30	37	53.99	CHANGED	thLTccElt-LTGh+.......ptupQtchLcpp.GI.ahhpscG+PlVsRpalp	....hLTcsEltpLTG.hc................hto+QpchLpcp.GlsFhhst.s.G...cPlVsRphh....................	0	4	16	28
+13829	PF13987	YedD		YedD-like protein	Bateman A	agb	Jackhmmer:B2PRC7	Family	This family of proteins related to the YedD protein is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. These proteins are lipoproteins.	27.00	27.00	33.90	63.30	21.60	18.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.41	0.72	-4.49	10	460	2011-04-28 09:05:55	2011-04-28 10:05:55	1	1	457	0	23	121	2	110.60	86	80.58	CHANGED	VVKTPAPAtLsGYWQopGPQSuLVSP-AIASLlVTp-GDTLDCRQWQRVIAhPGKLTptsD-hhNVTpKh-VYsLEh-GssLEYDGMTLpRVDRPTsECtphLsKt....PLssP	..VVKTPAPDWLsGYWQTKGPQRALVSPEAIGSLIVTKEGDTLDCRQWQRVIAVPGKLTLMSDDLTNVTVKRELYEVERDGNTIEYDGMTMERVDRPTAECAAALDKAPLPT.P........	0	1	2	13
+13830	PF13988	DUF4225		Protein of unknown function (DUF4225)	Bateman A	agb	Jackhmmer:B2PH01	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 182 and 282 amino acids in length.	24.10	24.10	24.40	24.60	23.60	24.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.99	0.71	-4.79	24	185	2011-04-28 09:36:09	2011-04-28 10:36:09	1	5	122	0	37	140	1	160.80	32	59.07	CHANGED	Ippl+pEppsLccQsphlpppphp.hh.hph............cppphhthhltulGlVuGGsQlhuGhulh...hso......tsshsthhGusLlscGsNslhEsshtlh...tcp..........shpG.l+cuYcpsAp.hlGhscpsushsYssVDluhShYGhhphh........................lp......P..ssaRLa+.YlssDah+thpp.....MopstL	...............................p.lp.E.tphppp.phhpttphchalpsch............EcpplIsYVhtulslVs...uGhQlVuGsGhl...hss......tssluhhsGshLlhcGANslhEuhthLh.....hsc..........psoG.lccsYtssAc.hhGhsp.psu.huYpslDluhShYGhhphh................................h+......P..sshRLa+.YlssDahpphpphsp............................	0	1	11	18
+13831	PF13989	YejG		YejG-like protein	Bateman A	agb	Jackhmmer:B2PI82	Family	The YejG protein family is a group of functionally uncharacterised proteins related to Swiss:P0AD21. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	27.00	27.00	58.50	58.40	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.27	0.72	-3.98	16	534	2011-04-28 09:51:31	2011-04-28 10:51:31	1	1	532	0	39	115	1	106.00	82	93.71	CHANGED	lQLSVVHRLPQSYRWloGasGsKVEPlP..sshss-ssLlGLKLLSHDGssAWplMcpLppoLs-IQlssullEWEGEPCLFl++pDESAshCRLKNhGVAIAEshsu	.......LQLSIVHRLPQNYRWSAGFAGSKVEPIPQ.NG...s.s............s.DNSLVALKLLSPDGDsAWSVMaKLSQALSDIEVPCSVLECEGEPCLFVNRQDEFAATCRLKNFGVAIAEPFSN..	0	1	9	24
+13832	PF13990	YjcZ		YjcZ-like protein	Bateman A	agb	Jackhmmer:B2PJH4	Family	This family of proteins is functionally uncharacterised. The family includes the YjcZ protein from E. coli Swiss:P39267. This family of proteins is found in enteric bacteria. Proteins in this family are approximately 300 amino acids in length. There are two conserved sequence motifs: FGD and MPR.	27.00	27.00	28.10	27.60	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.60	0.70	-5.26	10	540	2011-04-28 09:57:24	2011-04-28 10:57:24	1	1	319	0	13	209	1	258.80	62	90.92	CHANGED	hVDLApG.-ss+sththtppp.pFRpRLppplhupophRpashsushupsLthsLpLlEcLsu.LsPGHLALTplsc+LspLppssustAphossltpQLtsLs-paspRssahEcsLsptsLhspAtcHsEQIFoRWRAGcYsuWSLsGRCYlALEELRWGAFGDACR.LussshsshLlDsLRs....cAsptLApslpAuPsTRHaYHpWLs.ssstsuss-asDhLuWLGDWCssD+HPVsWSVTQpWQsVuLGMPRLCSAcRLu-AMVEEIF	...............lVDhApG.Dst..p...Atpp..pFhcRLhptLhucsthpp.s.su.LstslphpLphlpcLso.LsssphAlTpls.........p+lu.L.p..stR.tph........s-h.pQlhsLh-.hpt+hpahEctLpphs.l.pAt.p.EQIFohWpAGt.YsuaS.sGRCalsLEELRWGAFGDshR..Gps.ttVs.LLs.LRh....KAhpplApp.suusTsRh..hhpWhu.pup......sss-atDhlsWLGcWsot-+pPVhWSsTQthpplsltMPRLCSApRLutuMV-EIF..................	0	1	2	6
+13833	PF13991	BssS		BssS protein family	Bateman A	agb	Jackhmmer:B2PS04	Family	The BssS protein family is a group of proteins that are involved in regulation of biofilm formation [1].  Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	40.70	40.40	26.80	22.00	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.32	0.72	-4.25	16	542	2011-04-28 09:57:45	2011-04-28 10:57:45	1	1	527	0	44	132	1	71.10	83	86.86	CHANGED	HPlVGWDISTVDuYDAhMlRLHYLSotpQs.EsApVscThWLTTDlA+QLIsILpAGIsKIEou-htssshp+	.HPLVGWDISTVDSYDALMLRLHYQTPN+sE.pE.GTEVGQTLWLTTDVARQFISILEAGIAKIESGDa.sNEYR.R......	0	2	10	27
+13834	PF13992	YecR		YecR-like lipoprotein	Bateman A	agb	Jackhmmer:B2PR21	Family	The YecR-like family of lipoproteins includes the YecR protein from E. coli Swiss:P76308. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 110 amino acids in length.	27.00	27.00	27.20	43.20	26.70	24.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.72	0.72	-3.81	19	390	2011-04-28 10:03:24	2011-04-28 11:03:24	1	1	385	0	20	105	2	73.10	73	71.33	CHANGED	ssuSpssGlVcLuYp.....uhhpss.psDthtutthAspcCppWGYssAcsFGpss....psCshhsGph.....ChspplTlpYQC	..S.EssssoGIVRLsY-....QAaLQ+A..+TDcYVS+GlA-RACQQ.GYocAlPFGQPV....GsCSLaAG.SL.....CLNTcFTLSYQC...	0	2	2	12
+13835	PF13993	YccJ		YccJ-like protein	Bateman A	agb	Jackhmmer:B2PKP7	Family	The YccJ-like family of proteins includes the E. coli YccJ protein [1] Swiss:P0AB14 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	75.10	75.00	25.20	24.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.24	0.72	-3.90	6	468	2011-04-28 10:07:47	2011-04-28 11:07:47	1	1	467	0	26	65	2	68.90	92	92.19	CHANGED	KsHHVuEWAsVRcTSsEIAEAIFElAphDEpLAEcIWE.EGSDEVL.hAFuKTscDpLaWG-cTlERKNV	...KAHHVGEWASLRNTSPEIAEAIFEVAGYDEKMAEKIWE.EGSDEVLVKAFAKTDKDSLFWGEQTIERKNV....	0	1	3	15
+13836	PF13994	PgaD		PgaD-like protein	Bateman A	agb	Jackhmmer:B2PKR8	Family	This family includes the PgaD protein from E. coli Swiss:P69432. The homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (beta-1,6-GlcNAc; PGA) serves as an adhesin for the maintenance of biofilm structural stability in eubacteria. The pgaABCD operon is required for its synthesis and export. It has been shown that PgaD is essential for this process [2].	27.00	27.00	33.80	33.70	25.60	24.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.70	0.71	-4.69	34	382	2011-04-28 10:23:42	2011-04-28 11:23:42	1	4	353	0	38	146	4	123.60	45	83.02	CHANGED	LIIspp+hhs..p+hhshhlThhhWshalaLhhsh...hlhhhlsht.hht.h..htshtsthtslthahhlhlhsuslLlhWApYNphRapscp++ph.....ls.c-lAppasls..pptlpphpps+lhs.la.aD-cGclhp	.......LIIspppp.s..phhlDhlsTslhWshFhhhlhhhh..llht.............ahapSputopLpaYhLLAlANAVVLIlWAhYN+L...RFQcpp++Ashp.....hospEY.....AcSLAlP...-ELhQQLQKS++hoVHasspGpIp.h..........	0	8	20	28
+13837	PF13995	YebF		YebF-like protein	Bateman A	agb	Jackhmmer:B2PQW6	Family	The YebF-like protein family appears to be a group of colicin immunity proteins. As well as YebF the family includes cmi, the colicin M immunity protein [1]. This domain family is found in bacteria, and is approximately 80 amino acids in length. The alignment contains two conserved cysteine residues that form a disulphide bond in the solved structure [3].	27.00	27.00	28.60	28.90	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.81	0.72	-3.97	23	531	2011-04-28 10:25:30	2011-04-28 11:25:30	1	2	485	4	22	151	1	88.40	73	73.86	CHANGED	RssKhsuCssLspsQlAApVKcDFLQNRIsRWssD+.KtLGpscP.VsWlssp-I...sGc-ssapVPLTVRGs+sD+pYpVhlDCpsGTIoYs	....p.SVpFPpCEGLDAAGIAASVKRDYQQNRlsRWADDQ...KlVGQADP.VAWVslQDI...pGK.DDKWoVPLTVRGKSADIHYQVsVDCKAGhAEYp.....	0	1	6	14
+13838	PF13996	YobH		YobH-like protein	Bateman A	agb	Jackhmmer:B2PQU4	Family	The YobH-like protein family includes the YobH protein from E. coli Swiss:Q2MB16 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: GYG and GLGL.	27.00	27.00	31.60	31.40	20.10	17.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.22	0.72	-4.05	15	454	2011-04-28 10:29:34	2011-04-28 11:29:34	1	1	451	0	30	97	1	69.00	76	88.65	CHANGED	+hlIRslllLAllWlulLhSGYGVLlGSpcNsAGLGLQCpYLTARGhsTAQYlHoDSGlIGlo-CPLLRK	..RhIIRslhLlALVWIGLLLSGYGVLIGSKcNAAGLGLQCpYLTARGTSTsQYLHTcSGhlGI.oDCPLLRK..	0	1	6	18
+13839	PF13997	YqjK		YqjK-like protein	Bateman A	agb	Jackhmmer:B2PL82	Family	The YqjK-like protein family includes the E. coli YqjK protein Swiss:Q47710 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue R that may be functionally important.	27.00	27.00	28.00	27.50	25.50	25.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.27	0.72	-3.80	39	560	2011-04-28 10:34:02	2011-04-28 11:34:02	1	2	555	0	59	168	6	72.30	73	73.50	CHANGED	LLppIpQQRh-LusptppWhchTsshDRuWpplh....phRpahh.luuulhAlhulR+.Pp+lhRau+R.uhusWushR	....LLSQIQQQRLDLSAS..R..R-WLEsTGAYDRtWNhLL....SLRSWAL.VGSSVMAIWTIRH.PNMLVRWARR.GFGlWSAWR.......	0	6	25	41
+13840	PF13998	MgrB		MgrB protein	Bateman A	agb	Jackhmmer:B2PQU3	Family	The MgrB protein is a short lipoprotein.  The mgrB gene has a mg2+ responsive promoter [1]. Deletion of mgrB results in a potent increase in PhoP-regulated transcription [3]. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.	27.00	27.00	33.40	49.50	19.30	18.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.88	0.72	-7.32	0.72	-4.17	14	404	2011-04-28 10:41:38	2011-04-28 11:41:38	1	1	401	0	18	57	0	29.00	90	61.90	CHANGED	LYLlAlsshCDQG.tpFh.GICsITcalPa	LWAQVFNMMCDQD.VQFFSGICAINQFIPW	0	1	2	10
+13841	PF13999	MarB		MarB protein	Bateman A	agb	Jackhmmer:B2PLW6	Family	The MarB protein is found in the multiple antibiotic resistance (mar) locus in Escherichia coli. The MarB protein is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved GSDKSD sequence motif.	27.00	27.00	28.10	28.00	21.50	20.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.06	0.72	-4.39	10	439	2011-04-28 10:46:09	2011-04-28 11:46:09	1	1	435	0	13	87	1	65.30	69	90.91	CHANGED	uuAslsLLlLsSGQuhAEQTppPsspsscDslllPsupcQSPFDLNHMuAGSDKSDELGVPYYNp+	..SAIAuALILFSAQGVAEQTsQPVVTSCusVVVVPsSQEQPPFDLNHMGTGSDKSDALGVPYYNQp...	0	1	1	8
+13842	PF14000	Packaging_FI		DNA packaging protein FI	Bateman A	agb	Jackhmmer:B2PPD2	Family	This family includes the lambda phage DNA-packaging protein FI. Proteins in this family are typically between 124 and 140 amino acids in length.  There is a conserved EEE sequence motif.	27.00	27.00	29.10	28.90	22.30	21.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.39	0.71	-3.93	13	521	2011-04-28 10:50:25	2011-04-28 11:50:25	1	3	289	0	3	215	0	120.80	49	94.02	CHANGED	TKEc.lpRLcELAshLGREsDhSGSuA-lAQRVAEhEEEls.............suss-ssssccss.supp-psssspsp.....tsps-hVpVcsLtoLHhsAlcsssscsV.phV.sGpslhVsussAsshlssGLA	.......TK-E.ltRLcpLut.LsR-ssloGottElA.RVAEhEEELs.............suupDs.susE...huccs...pssosps-pl.......psousLssVhsLssLHssulcsppsEPV.thVhsGpshhVsuulAspMs-+GhA...................................	0	0	0	1
+13843	PF14001	YdfZ		YdfZ protein	Bateman A	agb	Jackhmmer:B2PLX9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved YDRNRN sequence motif. The E. coli protein has been shown to bind selenium [1].	27.00	27.00	27.40	27.40	21.90	20.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.06	0.72	-3.70	11	477	2011-04-28 10:55:07	2011-04-28 11:55:07	1	2	463	0	21	77	1	63.40	78	94.39	CHANGED	+sYDRNRNAIosGsRVMluuoGpsGVIKAIHu-GhospQlRRuKsVplcGs-t+asPl-LlRLG	.....pTYDRNRNAITTGSRVMVSGTGHTGhIhuI-oEGLTAEQIRR...GKTVlVEGCEEKhAPlDLIRLG...........	0	2	6	12
+13844	PF14002	YniB		YniB-like protein	Bateman A	agb	Jackhmmer:B2PNH1	Family	The YniB-like protein family includes the E. coli YniB protein Swiss:P76208 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 180 amino acids in length. This family of proteins are integral membrane proteins.	27.00	27.00	30.40	30.00	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.86	0.71	-4.79	20	546	2011-04-28 10:57:37	2011-04-28 11:57:37	1	1	541	0	42	162	4	162.50	80	91.65	CHANGED	lhGWllFIPALlSTlISllphhat+u-ctpGINAVh.DFh+lMl-MlRFNTPFLNhFWpNSPlPsasth..uuuNlhFalIYlLIFVGLALpASGuRMuRQl+aIREuIEDQLILEpAKGs-GhTRppLEp+IslPR.HTIFlQhFsLYlLPlllullGYhhlKLLGh	..IlGWVIFIPALlSTLISLLKFM.s+pEpQEG......INAVMLDFTHVMIDMMpsNTPFLNlFWYNSPTPNFs.....GGlNlMFWlIFILIFVGLALQDSGARMSRQARFLREGVEDQLILEKAKGpEGLTREQIESRIVVPH.HTIFLQFFoLYILPVIsIssGYhFFSLLGF................................	0	2	10	25
+13845	PF14003	YlbE		YlbE-like protein	Bateman A	agb	Jackhmmer:O34958	Family	The YlbE-like protein family includes the B. subtilis protein YlbE Swiss:O34958 which is functionally uncharacterised. This family of cytosolic proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a conserved WYR sequence motif.	27.00	27.00	43.10	42.90	22.90	18.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.19	0.72	-3.89	14	143	2011-04-28 13:02:23	2011-04-28 14:02:23	1	1	143	0	20	63	0	64.70	64	81.46	CHANGED	p.-L+pFIRppPhWYRpLoRpPpplsshEh-AhpaYcKTlPc+V-+hssslpMApMMhpMhpAM+	..D.EDLsRYIREQPaWYRKLoRNPEEhEAFELAAMpHaKKTIPDKVEKFQNQLulASlMI-MFQhMK...	0	3	12	14
+13846	PF14004	DUF4227		Protein of unknown function (DUF4227)	Bateman A	agb	Jackhmmer:C0H451	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	33.30	33.10	26.50	26.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.28	0.72	-4.14	18	158	2011-04-28 13:05:32	2011-04-28 14:05:32	1	1	157	0	29	79	0	70.90	58	90.84	CHANGED	+plhcslKVFlLFTGsTlLFYYullWlscEYpsYHRYDEPcGsAVKVhphpssp.ph..sa.h-RLhhFYhsGE	.........KhsaDuIKVFLLFTuCTILFYaAILWlN-EYEsYHRY-KPKtcsVchV..ous..c....EPsKD....ua.lsRhhFFYcNGE.	0	7	19	21
+13847	PF14005	YpjP		YpjP-like protein	Bateman A	agb	Jackhmmer:P54172	Family	The YpjP-like protein family includes the B. subtilis YpjP protein Swiss:P54172 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.	27.00	27.00	56.80	56.00	25.50	18.40	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.89	0.71	-4.40	15	144	2011-04-28 13:07:43	2011-04-28 14:07:43	1	1	143	0	23	80	0	136.90	68	68.73	CHANGED	ssc.spppahct.lhppA.cQSh.hKFGsKIuPhIE-Ea+chILPKlEcsIs-hlsphs---.LppLslS-sPuuGpGEKIFHlYsp+TG-DllRFHVRRD+PPpcGYaFNFHYHot-DsFpsHHELGsIYWcKNTPPpW	........s.+LTsDTFIsY.AMQEAEKQSM.pKFGoKIGPVIEDEFKDVILPKIEEAIAELAs-VPE-.S.LQSLA.ISpKP.AGGNsEKIFHVYDTKTGsDLLRFHVRRDHPPQDGYYFNFHYHcaDDGYouHHELGsIYWNpNsPPKW...	0	6	15	17
+13848	PF14006	YqzL		YqzL-like protein	Bateman A	agb	Jackhmmer:C0H452	Family	The YqzL-like protein family includes the B. subtilis YqzL protein Swiss:C0H452 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	27.00	27.80	26.30	26.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.54	0.72	-3.76	20	174	2011-04-28 13:10:03	2011-04-28 14:10:03	1	1	174	0	37	81	0	44.00	51	92.99	CHANGED	DFoWKlFupTGsIDoYLLaKE....lEccsc.p.sppppE...pchs...shp	...DFTWKhFSpTGSI-TYLLhKE....hE+-sp-ch-pcE-E..hsclD.sh.s.............	0	18	29	31
+13849	PF14007	YtpI		YtpI-like protein	Bateman A	agb	Jackhmmer:O34922	Family	The YtpI-like protein family includes the B. subtilis YtpI protein Swiss:O34922 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 101 amino acids in length.	27.00	27.00	36.20	35.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.66	0.72	-4.06	24	163	2011-04-28 13:12:27	2011-04-28 14:12:27	1	1	162	0	30	111	0	80.50	53	87.64	CHANGED	hlhlIlhShshYlYaKl+t.hRopcshc+phasuKusluLGlFlhhFulNQhhl...hpoTlshlluhlFlllGhushatGa+sa+HYhPhht	...........................................hhlhhoh.hhhaaph+..h+st...shEK........tahSuKSuMALGoFVLFFGINQaFL...phSTsclI.VGllFlLhGuuSlasGaRpYKHahPLA.l......	0	9	21	24
+13850	PF14008	Metallophos_C		Iron/zinc purple acid phosphatase-like protein C	Coggill P	pcc	Jackhmmer:Q9LMX2	Domain	This domain is found at the C-terminus of Purple acid phosphatase proteins.	23.00	23.00	23.00	23.00	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.93	0.72	-3.89	130	888	2011-04-28 16:05:58	2011-04-28 17:05:58	1	20	198	20	604	904	23	64.20	29	12.89	CHANGED	pAPlaIlsGsuGs.....th...ss.....hs..p....s....p...ssao.s.h....cp...s.caGauplphhNpTcLpacalc.s..p...s.........G..p..V..hDph	.....................................uPlalshGsu...Gs...........hh...sp...................hh.p...........s....p...PsaS.sa.........Rp....s.saGaupLplh.NpT....+hhapahc.s.p...D.........G..p..l..hDp.................	0	189	377	518
+13851	PF14009	DUF4228		Domain of unknown function (DUF4228)	Coggill P	pcc	Jackhmmer:Q8GY70	Family	This domain is found in plants. The function is not known.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.22	0.71	-4.14	56	732	2011-04-28 16:07:15	2011-04-28 17:07:15	1	4	27	0	458	690	0	161.80	16	86.36	CHANGED	MGNslsssh.......stssssss+llh..sGplcch..pt....sls..AuElhtphPsHh................sss....tp...s....s.....pclt.........sLssDccLphG..clYallPhpp.htst.hstps....hs..plt....ht..sspstpp........htttpsp.h...............t........ppssss.sp.h.......hh...hhs.cppl...pchh.............p..pt.........sspt..hsp.h......tptt............hp...ppp....p.tspspsW+PpL-oIsE	......................................................MGst.t......................t.tss+lht.........s...........G.plpch......th.............s..hp..suclh....t.t........P.s.p.h.l.............................stsps..ht...h..........s....................tph................hl.t..scppLp.G..plYall.Phpp.h...p.....hpttp.............hs..tht.........ht......sttthtt.....................ttt.tp.h..............................................................tttst...ht.......................t.h....tphh........................................t.....................t...................................................................................h...................................................................................................................	0	45	266	375
+13852	PF14010	PEPcase_2		Phosphoenolpyruvate carboxylase	Coggill P	pcc	manual	Family	This family of phosphoenolpyruvate carboxylases is based on seqeunces not picked up by the model for PEPcase, PF00311. Most of the family members are from Archaea.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.85	0.70	-6.19	27	105	2012-10-10 15:06:27	2011-04-28 17:21:18	1	1	102	8	53	798	438	495.80	36	99.07	CHANGED	IPRsMuTQHPDNs.hP.a.s.psshlsu-DElpEAahsao.....thGs-EhMWDaEGK-sDpaVl+KLlopY.caFpcphLGcDlaLThRlPNPplEpsEtKlLsEshtsIspsaDhuchh.....t.sssPIFEVILPMTsssccl.plhchYcchlt.pt...h.s....htlcEhlG-h.PcpIcVIPLlEDtsuhlpscpIlpcYh....ctt..c.pahRVFLARSDPAhNYGhluAsLhsKhALpclhclpc-hulplaPIlGsGSsPFRGphsPtslpps.lpEYsGlhTaTlQSAF+YDashccVhculcplpp.tphppst.lsp-c...hhplhpphoppYppplcplAshlNplAphlPpRRpRKLHlGL.FGYuRsh.ssl..............................sLPRAIsFsuuLYSlGlPPELlGhusL...sc...cch......-hlpcsa.tltcDLphAscahN.-........ssthhhstctlhtlp-th-hhtp.............pcHp.hsppllpshppt.....................hcshllchuplRtFLG	.......................................................................................................................................IP+sMuTQHPDNsthP.a....s..psshIsup-ElpEAahuao.....tLGs-EhMWDaEGKcsDtaVlc+LhopahcaFppp.LG+DhFLThRlPNsphEcsp..pplhspshtslsps..hDhAchh......t.sttPlFEVILPMoposcplhp.l..t.chapchls..................hthc-..a.h.s.ch..sc.pIclIPLhEDhsuhLpsccIlccYh.........cph.......c..cYhR.......VFLARSDsAhsYGhluulLusKhALsclhchscchulpIaPIlGsGSsPFRG..s..L..o.P..cs..l.-ch....l....pE...Ys....G......lp.ThTlQ.....S....A...F......+...Y...D......a.....s.......h.....-.....c.....V.......p..p....A.....lpp....l.......ps......hph.....sps.....p.lscc-.....thhhclhp.phu.ppYppplcplssslspluphlPcRRcR+hHlGl.hGYSR.s.l.ssl..............................sLP..RAIsFTu......uhY.S.lG.l.P.PE.l.l....Ghu...pl..p..sc....cch......-hlhchYss..h..+cDlphAu+ahsh-............hsthhhspcshtcl...cEDlchhpp..hth........ppcH.sthsppllphhct.h....................hpphIhchAplR+hLG...........................................................................................................................................................................................................................................................................	0	17	31	43
+13853	PF14011	ESX-1_EspG		EspG family	Bateman A	agb	Jackhmmer:A5TZ16	Family	This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis.  These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread [2]. Proteins in this family are typically between 254 and 295 amino acids in length.	27.00	27.00	29.20	27.90	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.35	0.70	-5.12	66	505	2011-04-29 10:18:57	2011-04-29 11:18:57	1	2	116	0	134	371	0	245.10	22	90.72	CHANGED	Lossp......h.hLh-.thuhsp.hP................hsLsls..s.hss..tscRsshpppshs......pLp..ttGlhsst..plcsplsshlpsLscPshpl-sthhh.................sup....hRsh..............sutpss............psVlA..spss.......stlslpsht........ssuLssslsssLss...ss.Pup.hpslolPssphtpstp............t.tsst.htshlpphGl...sssssps.ltphhspspstsu.husptp.sst.......pspsssslshhD..Tsp.GRhlspsppu.ssp...W.solsPus.spplsptlppL	..........................hossshhhltp.hhshsp.hP................hsLslp....shhss........pspctthtcpshs..........pLs.thGllssp..t.....hsstltshlclLspP-hpltsthht................................ssp........hRsl.................lupcus............pt..VlA..hRsu.......shlslpsss.............................spsLsshlsssL....ss.............ss..PAs.hpslolstpphtcssp...........................s...ss.lpphul................ssssht...s.ltphhssspststhlusppc...sss..........ptpssssl.ulhD..oss.GRll.sts..p..puhsuc...a.hshsPuo.sttlttulpp.........................................................................	0	39	97	124
+13854	PF14012	DUF4229		Protein of unknown function (DUF4229)	Bateman A	agb	Jackhmmer:A5TZR1	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	27.00	27.00	27.60	31.20	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.33	0.72	-4.08	62	283	2011-04-29 10:23:44	2011-04-29 11:23:44	1	1	267	0	100	247	24	68.30	33	61.31	CHANGED	hlhYshsRLsLhsslssl...lh.hluhhhh.....shhluslhAllluhsLShhlhpphRpcsstsluth....sppR	.....hlhYshuRLhLhlslsul...lh.hl..uhhhsh......hsllluslhALllAhPLShhlFpslRccsotslAthscpR..........	0	29	76	95
+13855	PF14013	MT0933_antitox		MT0933-like antitoxin protein	Bateman A	agb	Jackhmmer:A5U0U8	Family	This family of proteins contains the MT0933 protein Swiss:O05901 which has been identified as an antitoxin to /protein MT0934 [1]. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	27.00	27.00	27.20	28.90	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.50	0.72	-3.86	58	385	2011-04-29 10:29:15	2011-04-29 11:29:15	1	4	326	0	102	249	0	55.50	39	74.87	CHANGED	lhD.............K..uKchlspp....t...........-plc....pGlDKAu-hlD..........cKTGGKYucplDpup-tAcctls	..................................hhD...........KAK-hlspp.....t...........Dpl-....pulDKAGchVD..........c+TsGKauDpIDpup-us+ctls.......	0	36	78	98
+13856	PF14014	DUF4230		Protein of unknown function (DUF4230)	Bateman A	agb	Jackhmmer:C7QH51	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 203 and 228 amino acids in length.	27.00	27.00	28.30	27.00	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.01	0.71	-4.36	170	626	2011-04-30 09:44:43	2011-04-30 10:44:43	1	1	536	0	162	520	25	157.40	18	73.09	CHANGED	lpplcslucLtshphphpplhshpsppphh.................h.hspp+hlhlhsu..plpsul.DLsclp.p..lph........pscp..................lplp.LPpsclh.ssp...lD...tp..hpha.sppps....hhst..........p.p.-hsphhppu.cpphtcpsh..pss.lhppAc...ppupphlptlhps....hth.......pphplph	....................................................................pplcplucLsshphthpcllshccsthhhh.....................hshsc+phhllhpuplph..sl.DL.pchs.t.lpl........sscp........................lplp.lPp.sclh..psp..lD....tp.....hcha..cppsu......hhs...............hs.p.-tsphhpcA...ccplpcpsh....pps..lhppAccsApsh...lpslhps....hsh.......pphph..................................	0	70	128	153
+13857	PF14015	DUF4231		Protein of unknown function (DUF4231)	Bateman A	agb	Jackhmmer:C7PX93	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 148 and 288 amino acids in length.	24.70	24.70	24.70	24.70	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.35	0.71	-4.08	76	408	2011-04-30 10:14:04	2011-04-30 11:14:04	1	3	361	0	94	240	33	109.30	30	56.78	CHANGED	.shhphhcpputpspptah.......hhphhpllh.hhuuh.....lsh....................h.......................tt.......shthhphsss..llus...hhshhsulhshh........phpcp....WhphRsssEtl+ppph....tah......................hpss.at..........ssppstphh	................................ss...lsaa.++usppR+cY+........lL+lspIlsuhLhAl.....IPh..................................................................sscphpllsl......sLSu...lshlspulhsla........sh+-s....WhsapcTAphLc+E+a..lYt.............sp.sp.Ys......sppc.....................................................................	0	23	60	84
+13858	PF14016	DUF4232		Protein of unknown function (DUF4232)	Bateman A	agb	Jackhmmer:C7PXZ8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	27.00	27.00	27.40	27.30	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.51	0.71	-4.49	69	475	2011-04-30 10:33:41	2011-04-30 11:33:41	1	4	262	0	148	421	0	132.80	20	63.79	CHANGED	CssssLshss.tssps..usGtp....hhhlslsNsuspsCsLpGa.Pu.Vshh.sssGs..............sssuscpss...........ssssVsLsPGpsAhAslthss..ssssss..........tssssss....ltl.tsP.ss........sssl.......tlshsss.........................................ssssplpVsshpss	...................Ctsstlphsh...s.ss...pu.......uhGtp..hhhLslp.N......suupsCtLsuh...Ps.lphh...sssGs.............hss..s..sttpss.............sspslsL.sPGpsstsslpats..ssssss..............shtstt...lhlh.s..st.........tsh.........l.h..h........................................................t...................................................	0	35	120	146
+13859	PF14017	DUF4233		Protein of unknown function (DUF4233)	Bateman A	agb	Jackhmmer:C7Q8C9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	27.00	27.00	38.20	38.10	23.30	21.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.67	0.72	-4.12	61	349	2011-04-30 10:53:39	2011-04-30 11:53:39	1	1	349	0	92	219	71	105.30	33	79.73	CHANGED	Rs.lhAusLlhEulVlhLAhhVshplss.....h......sssshshssslslshllhsul.p+.sWulhlshsLQls.llsushlhPuhhhlGllFuhlWhhslhhtpclccchtct	....tVhAusLhhEsIVlhLAlPVhhtVuu..........h.........sshuhshssshsVlhllhush.tR.s.....WulhlshsLQlh.hlhushlhPsh.....hhlGllFuAlWhhlhaLt+clcpp.t.........	0	28	70	88
+13860	PF14018	DUF4234		Domain of unknown function (DUF4234)	Bateman A	agb	Jackhmmer:C7Q4E0	Family	This presumed integral membrane protein domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length.	23.70	23.70	24.00	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.76	0.72	-4.24	77	247	2011-04-30 12:47:06	2011-04-30 13:47:06	1	8	203	0	77	217	14	81.90	22	50.02	CHANGED	Rslshhll.Loll.......ThGIYslaWhhphsc-......................lsth..ssct..shshshhllls......................ll............................TsGlashaWha+hupcl.pthptp	............................hslhhhll.Loll.............ThGIYslaWhhphsc-.............................lsth...stct..thshhhhllhh.................................hl.............................................Thu..lh.lhWhaphuptl.t.....tt..................................................................................................	0	32	51	61
+13861	PF14019	DUF4235		Protein of unknown function (DUF4235)	Bateman A	agb	Jackhmmer:C7PYA5	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 88 and 119 amino acids in length.	27.00	27.00	29.10	27.00	25.70	26.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.60	0.72	-4.13	66	301	2011-05-01 09:52:26	2011-05-01 10:52:26	1	1	285	0	89	219	10	78.20	30	77.74	CHANGED	aKhluhusuhsuGhlAs+lhptlWcps..sG.ccsP...csp...............................D.ctuhtcslsaAslpGulhull+shssRuuApshp+hssp	..........aKshuhAlusluGhlupKlhptlW+hl...oG..ccsP....pss...............................D...-huhscsLsaAslSGsh..hAssphhscRtss+tat+hs..s...........	0	32	67	82
+13862	PF14020	DUF4236		Protein of unknown function (DUF4236)	Bateman A	agb	Jackhmmer:C7PYP4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 402 amino acids in length.	27.00	27.00	28.70	28.40	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.71	0.72	-3.85	88	345	2011-05-01 10:59:28	2011-05-01 11:59:28	1	20	326	0	69	260	50	54.00	41	22.01	CHANGED	a+FRKol+luPG.l+lNlSKsGl.ShS..lGs+.Ghplsh..stpG.htsosulPGTG..loYpp	........h+FRKSlplsPG.l+lNlSpuGs.ShS....lGs+..Gs.pl.oh...ss+G.thsslulPGTG..LSY+...........	0	24	47	65
+13863	PF14021	DUF4237		Protein of unknown function (DUF4237)	Bateman A	agb	Jackhmmer:C7PYW1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 123 and 781 amino acids in length.	27.00	27.00	27.80	28.30	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.20	0.72	-3.71	68	319	2011-05-01 11:03:08	2011-05-01 12:03:08	1	23	246	0	96	292	2	94.90	31	19.49	CHANGED	pssLssGp.hlDRaG............s.........stGsFluPt.....GssaspRuLP...Pssh..........spsY+hYc.......Vh+.....shs.l...................................htGslA..PWF.sQPG..GGsQ......a...................hh.....stslppLlppG.......hLccls	.......................p...l..Gs.hlDRaG............sstGpalush.....sssa..tpRuLs.sssh.............tpsY+hYp.......Vhc......sh...l..........................................................htG.lA..PaFuQPG..GGhQ.h.................ph................hslppLlcpG....hLcp..................................	0	27	56	81
+13864	PF14022	DUF4238		Protein of unknown function (DUF4238)	Bateman A	agb	Jackhmmer:C7Q0A2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 274 and 374 amino acids in length.	27.00	27.00	27.30	27.20	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.69	0.70	-5.12	94	367	2011-05-01 11:09:05	2011-05-01 12:09:05	1	5	301	0	117	350	7	261.60	15	77.69	CHANGED	+pHaVP..phaL+......pF............t................sppsplh.............................shph..................pppphhttshp.....shstcpphYshps.s.t.........................................................plEcth..spl.Es....phuphlpplhstpt..............lsspppp....tlhtFlshQhhRosthppphhphhpthhp.h........................................................t..t.........t.......tthttpthhhthhpphhp...........................htthhhphphtl....hhspssttFlTSDpPlsh...............................tt.sht.............pthplh......hP..loPchhlhh..........................................................................ttptttthhhhsp.pplp...plNph.hpp....up.......................chlaupspsththh	.........................................................................pHalPph.hL+ta..................t...................tppthlh..............................................................hhth...................tttthh..hs..hp...........phshtpthYp..t.......................................................................................lEchh..uhh.Es....phsphlp.tlhptht..............................................lstpptp.........tlh.palh........h.hhRs.sh....ttphhphhpt.hp.h..........................................................................................................t...tph....t.....................h..t..h..hh.p.th.p.............................................h...h.htphphtl.........stsppthlsSDs.......Plhh.............................t.s.....................phhplh....hPloPplhlhh............................................................................tt.p..hh....h...h..st.p....p....lp...........hNt...h.hpp...u.......................p.lh.tpt.....hh.......................................................................................................................................................................................................................................	0	45	75	102
+13865	PF14023	DUF4239		Protein of unknown function (DUF4239)	Bateman A	agb	Jackhmmer:Catenulispora acidiphila 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 254 and 270 amino acids in length.	21.40	21.40	21.50	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.36	0.70	-4.97	9	249	2011-05-01 11:18:32	2011-05-01 12:18:32	1	4	178	0	136	268	20	198.00	18	72.03	CHANGED	lhsslullaushhuhslshLhppasclpcslssEAslLthlscslhsh.tsc.....cppspthltsYsctl..........lscshshh..pcs..phshh...shs.lsslhshlpthcssspsp.pshtpphl....spltcLpclRtpRlphtthuLsstaalllhhhoshshlsa........hshhsspthhthhuhhlhs.hsushhlFh.h......cLscPFpGsaplsps.shsphl	..................................................................................................h...hluslaullluhshsssh....p....phspsppsltpE....As.s.ltplhpt..s.t.s.h..s.ts...........psplcttlpsYsp.t...l..............lpp-Wsth................pps..ph.s.p.............ssphl..s..p.lhp....p.ltshps.p..sstp...tthhpthl.............splspl....hpsRppRlt.t..s.p.s.sls.s..shWhhllhhusl..h..h.lsh....................hh..hhht.pp..h...hp...h.hh.h...slhu..shluhhlhllh......ph.-pPatG.htls.t.......hh...............	0	41	82	111
+13866	PF14024	DUF4240		Protein of unknown function (DUF4240)	Bateman A	agb	Jackhmmer:C7Q711	Domain	This presumed domain is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain Pfam:PF05406.	27.00	27.00	30.40	30.50	25.70	25.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.58	0.71	-4.29	59	244	2011-05-01 11:23:53	2011-05-01 12:23:53	1	6	205	0	77	229	6	128.60	31	61.94	CHANGED	Mscpc....FWpLlspsp........sss-tp.....thtchL....ps..........................tLsphssc-lhsFpphhpp...hhtc.uaphslW..uAAallpG............s.sSDDuFthFRsWLIupG+chacpsltsP..DsLuph....ptt............................................thEch.thlutcsacct	..................scpc....FWpLlcpuc...........tst-.-.......phtchL....pp...........................pLsphssc-llsFcphhpp...hhpc.u....Ys......sLW..uAAall.hG..............G..sSDDuFsa..FRsWLlupG+-sa-sslps.P..DsLsphht.h.pptt........................................sphE-l.halutcsYcp.t.........................	0	29	53	69
+13867	PF14025	DUF4241		Protein of unknown function (DUF4241)	Bateman A	agb	Jackhmmer:C7Q8Q9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 205 and 315 amino acids in length. There is a conserved GDG sequence motif at the C-terminus.	27.00	27.00	28.40	28.70	25.60	25.50	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.15	0.71	-4.51	46	192	2011-05-01 11:27:02	2011-05-01 12:27:02	1	5	160	0	42	186	6	172.60	31	66.89	CHANGED	plplsoGcllssDPL.............h.h..tstpP..ahpplssGpa.lplslsct.p..t............RhAss+l..................pascpc.....sspachAhhsspsl.ppl...c-u-.a......FGasVDAGhushsDhpstcthpcatpch.pcp.....hshY-DhFsphhpp...shtt.spapppss.shhsashssostslshFpSGaGDGh..YP....sYaGaDcsGplssllh	............lplsoGcllssDPL...............h...pspts....ahpplss.GpYslphtlspt.p..t............RhAss+l..................phscpc.....sstac..hAhhsspc...l.ppl...p-sc.a...FGasVDuGhushsDhpshpthpch.pch.pc.......hs.YsDhhs.phhpc...p..t.spappp..tG.thhs.h.hss...oshslshFpSGaGDGh..YP....sYaGhDpsGplssllh..............................	0	20	32	35
+13868	PF14026	DUF4242		Protein of unknown function (DUF4242)	Bateman A	agb	Jackhmmer:C7PZ36	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	27.00	27.00	27.40	27.10	26.40	26.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.47	0.72	-3.89	75	359	2011-05-01 11:30:12	2011-05-01 12:30:12	1	5	329	0	110	241	112	76.80	43	51.89	CHANGED	pallERc.....lPss..los-pltshpppssshhsch....ssVpWlcSaVs.tps...+.saClYpAPst-ul+ctsccu.GhPscpIscV	...cYLVpas.....IPcu....ITh-phhAp.++KsssthcEl....P-VcFhRoYVsEDhu....K.shCLYsAPDEEAVRRA++ts.stPlDsIp..h..	0	40	81	98
+13869	PF14027	DUF4243		Protein of unknown function (DUF4243)	Bateman A	agb	Jackhmmer:C7QAE2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 348 and 477 amino acids in length.	27.00	27.00	29.30	29.10	20.00	21.20	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.12	0.70	-4.99	118	340	2011-05-01 11:33:20	2011-05-01 12:33:20	1	10	167	0	246	351	4	303.70	23	73.39	CHANGED	tha............N...HhsHtlhulatLGAsssp....lppha...........-pptphhp.h............stphhs......psa....cphLG...cpchhtsalsFFpcElp...........pcG...hcpVlpcYha............ttpt................................h.pllstlhuGhhHPlI+LGaulEhs.pst......................llAEu..................LA.sAsch..s.h.thh..ss....ttts................................................................s.shh...pllpc.lpsstphps....ss.....................ht.thlh..cthcphh.hs...............................u.hh..........pphpcpht-hhpss....shhhsust................t..phDF.....hhlHslTuuhhlphll.hh......sspp+hpllc...hhhthslshYsupupPph.....hpplhphhs.t................................sWpplhpp.hsttps...Ds...HhsKhlRuhtp	..................................hpN...HhsHtlhuhathGAsspp....lppha...........-tttph.csh...................s.p.hst.....psa..........pphLG.................ctchhtsalsFFpcclt................ppG....hptVlpcala...............ttpt..................................phlstlhuGhhHPlI+LGaulEhp..p.t..........................lhuEu..................LA.sAsp....s.htthh..ss......t.t..........................................................................stshh...pllpp.ltt.s.tchps.....sh.....................ht.shlh......pt.cphh.ht......................................u.hhh...............pphpcpht-hh.pss.......................shhhssst................t..thDF.....hhlHhlTuuhhlthl..l..shh.......s.p.+hpllchhhh..hslshYhupspPph.t.ptl.h.s..h.st..t............................................sWptlhpp...sh.ts........Ds........HhhKhhRshh...........................................................................	0	71	141	213
+13870	PF14028	SpaB_C		SpaB C-terminal domain	Bateman A	agb	Jackhmmer:C7QBX6	Domain	This presumed domain is found at the C-terminus of the SpaB protein Swiss:P39774. SpaB is involved in the synthesis of the lantibiotic subtilin.\	\	\	\	  This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 317 and 1029 amino acids in length. The family is often found in association with Pfam:PF04737, Pfam:PF04738. This domain is found in isolation in some proteins. This domain is also found in EpiB involved in epidermin biosynthesis.	27.00	27.00	27.60	29.10	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.08	0.70	-4.85	142	404	2011-05-01 11:47:07	2011-05-01 12:47:07	1	9	270	0	119	365	3	254.40	19	35.28	CHANGED	W.hth+l..hsts.pt...-phlsptlsshlsph.....tts..hpt..aFFlRYtc.....st.....HlRLRl...pss..p.......thhtthhs.....tltphht.....hhtt.............................thhsphphss..YpPEht.....RYGG.ssshshAE...plFttDSthsls..hlt.............tthshph...................................................phlsuhshhp...............hhs.h.....................p..pt..........................................................hphhtchspptttt.ph.hps.tt....thhpltp.....hthht...s...t.th..........hhppttpthsthtphh.....................................................p.t.p..htsllssh.....lHhphNR..hGls.tppE...thlhph	........................W.hhh+l..atst.tt...-phlhctlhshlcph........tps..lsp..aFFlRYhc..................s...sHlRLRl.....phss.t...........htthht..............tlpphhp....thhpp.........................................shhsshphss..Yc.Eht.....RYGG..sshshuE....phFphDSthslp..hlp...............shphph......................hlsuhshhh.........hhp..hsh.......................s.ppt.................hphhpp.hhspth..tp......t.hpthht................thhplhp........ht.ht...t..th..h............hhpptpphhsphpphh.....................................................ttt.tpt.hpp....llsSh.....lHhptNR..hGls..hppEthhh.....................................................................	0	51	92	110
+13871	PF14029	DUF4244		Protein of unknown function (DUF4244)	Bateman A	agb	Jackhmmer:Catenulispora acidiphila 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	27.00	27.00	27.20	28.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.61	0.72	-4.87	53	401	2011-05-01 11:52:36	2011-05-01 12:52:36	1	1	400	0	101	287	10	54.10	44	67.72	CHANGED	tttpthtsttss-pGMuTAEYAluslAAsAFAulLhhllpSssVpshLpullppALs	.........hh....hhhhh.s-pGMuTAEYAlGslAAsAFAulLhtVlTussVhotLpsllspALp....	0	30	74	94
+13872	PF14030	DUF4245		Protein of unknown function (DUF4245)	Bateman A	agb	Jackhmmer:C7QKK2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.	27.00	27.00	56.40	56.30	26.20	24.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.52	59	339	2011-05-01 11:55:11	2011-05-01 12:55:11	1	1	335	0	84	236	22	175.20	31	88.33	CHANGED	Rhhp....ss+DMllSLsllllsshll.hhh........stsss.ss.lssVDssstlptsuc..ss.saPlttPp...lPcGWpssSu..chsshsu............ssshplGalTss......spYlplsQossssss.......hlsthssst.ps....sGspsluGp.sWphaput.........sscsshVtc.h....sssp......lllo.....GsAstc-hcslAsAlt	.........................t.ss+DMllSLuslllsshll.hhh....................stssc..pssl.pV.D.hpssltsstp..sh.uaPlttPp.......lPc...s.WpssSu..chsshss............uss.plGalosp......stYlulsQSsts.tct.......hVuu.lstuspp.........sGshsV.u...Gh...pWshasus-........stppshVsc.l...........Gss.pllls.....GsushcphpshAusl..............	0	26	62	80
+13873	PF14031	D-ser_dehydrat		Putative serine dehydratase domain	Bateman A	agb	Jackhmmer:A5U2B6	Domain	This domain is found at the C-terminus of yeast D-serine dehydratase [1]. Structures have been solved for two bacterial members of this family. The yeast protein has been shown to be a zinc dependant enzyme.	22.00	22.00	22.90	22.90	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.02	0.72	-3.79	98	1102	2011-05-01 13:05:54	2011-05-01 14:05:54	1	7	847	7	478	1062	313	98.80	27	25.73	CHANGED	AlhlhupVlStsp.......spsllcsGt+uluhDs..........u.....h..................th...sh..shs..................t..s..............................shphsth.u...-EHuhL........................p..h..........sss......ss.....................h........plG-hltlhssHsCsThshachhhlVc	..............ALpVhupVlSpsps......spsllDsGp+sluhDt.............u..h......st...............sh.uh.lhs..................ts..............................sh..plssh.s...-EHuhl................................p.h........sss..........st.....................l.......plG-hlplhPsHsCsTsshacthhll........................	0	134	278	399
+13874	PF14032	PknH_C		PknH-like extracellular domain	Bateman A	agb	Jackhmmer:A5U8Q1	Domain	This domain is functionally uncharacterised. It is found as the periplasmic domain of the bacterial protein kinase PknH [1]. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond.  A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	27.00	27.00	27.20	28.50	25.50	26.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.25	0.71	-4.73	68	678	2011-05-01 13:51:53	2011-05-01 14:51:53	1	4	94	0	115	462	0	188.20	19	66.25	CHANGED	sslsssslsslL.....Lsss-l....ssl.hGssthtsstsssshs.............sspsssspChushsssps.sYt........shs..sh+stsh.........tssssssth.lpQulssassspsApphh..sshssphpsCsstshsht...........tts.sttaplusssssss...hlshshsttsst.......hsCt..+shsspsNlll-lpsC...........sssssst...usplssthhs+l	........................................................h.sh.sstlsslL.....Lstucl....ssl.hG.ss.th.hs.th.stsht................sssssss.pCtsshshsts.sa.....shs...uhputsh..........t.s..ss.s...tsph..lsQuVssa.sssssAcpha..pshssphppC.sGpshshh.......................tsststthsluss.sssss....slshshtttss..................hpCt.....+shtlcsNVll-lssC...........ttspssss...usslssthhspl....................................................	0	27	69	99
+13875	PF14033	DUF4246		Protein of unknown function (DUF4246)	Bateman A	agb	Jackhmmer:Q59QG7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 392 and 644 amino acids in length.	27.00	27.00	31.80	27.70	23.20	25.30	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.81	0.70	-5.89	50	374	2011-05-02 10:30:38	2011-05-02 11:30:38	1	6	93	0	324	394	5	341.20	30	77.80	CHANGED	tsshts.hhTlREhsMlplMsplTDKPsWcpKlaDc.sIs.s+W+p...Eslspsp.................................................tlocphh-aslpELcaK....Aphac.cs..Gh.l.s..hss...........sVsKS..Dosls...ssLpppL+sul.phLcss....tsp.D.aHPuosppVlDLVHPSLFPLVYGRT+.llssth..lsl-..ssltt..GpGpllPh...sspppt...................h......ttht.hhaSp+FQWLPspVch.....................ssssss+IsSYINNLHPt+a+sLYpsIEpllspsIPhWNpsLs.h......................tsct.hRIph.ts..........................................p.pp.p.tps--.pch.cchp............pW.ppppphl.......................................P-P.ttFp......................................................sp.pttlsL.pccFp..ppGLQVIVKlAsIELTPEc.PpYsGG.sWHVEGph...............NEHIsATAlYYYDs-NITpS.pLuFRpts..-sp.......p.t...a-pss...........................p.palpplaGhcst...........ssshQplGuV.psppGRLlsFPNsl.................QH+VsPFcLtD+oKPGHR+hLsLaLVDPphR.IlSTANVPPQpp-WWs-tst	.........................................................................................................h...........................................................................................................................................................................................................................................h.....p...............h.........................................................................hh.h..t................................................................................................................hs.thphLPs.hth.......................t.thph.S.YlNNL.p..P.......h.Y...hltphhtt.ls.hp.hh................................................hh...........................................................................................................................................................................................................................................................................................h........................................................................hpl........t..tptlpl......IV+hssIpLT......Pp.p.P.p..a............ts......t.........WHhEG.h......................NEpIsuoslahhs..pN.lsts..pltFR..h.................................t........................................htpl.asht.t.............t.h.Q.lGsl..h....p....G........RhlsaPNhh.................QH+.psFpLhD.opP..GHp+hLshalVsP.....t..hc...l.hSTspVsPQp.pWh.p..h.........................................................	0	160	218	286
+13876	PF14034	Spore_YtrH		Sporulation protein YtrH	Bateman A, Eberhardt R	re3	Jackhmmer:C0H3P8	Family	This family of proteins is involved in sporulation. It may contribute to the formation and stability of the thick peptidoglycan layer between the two membranes of the spore, known as the cortex [1]. In Bacillus subtilis its expression is regulated by sigma-E [2].	27.00	27.00	77.80	76.70	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.19	0.72	-4.09	29	206	2011-05-04 11:44:28	2011-05-04 12:44:28	1	1	206	0	47	114	0	102.90	53	87.53	CHANGED	hsshlhsFFlAhGVllGGullGGlGAhLsscPPLpshhpLAspLKIWAllAAlGGTF-slpslEpGlhpGphcslhKQllhIluAhhGApsGhhlIpalstsp	.hs.hlIlSYFIAFGVlLGGSLIGGhGAaLhG+PsLT........h........hsphApsL+IWALVAAIGGTFDoFYuhERuhFtG-h+DIlKQlLLIhhAhGGhQTGhlII+WLTQE....	0	20	36	39
+13877	PF14035	YlzJ		YlzJ-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:C0H413	Family	The YlzJ-like protein family includes the B. subtilis YlzJ protein Swiss:C0H413, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 72 amino acids in length. There are two completely conserved residues (L and G) that may be functionally important.	27.00	27.00	36.10	36.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-9.15	0.72	-3.92	39	213	2011-05-04 11:51:42	2011-05-04 12:51:42	1	1	213	\N	58	134	0	64.20	40	93.42	CHANGED	LYTlhP.Ehla...ttpcsthpspp...plphs.Gl.llVcthps..sp.....hcllRllSTsPhcYLpschsPGshlp	.............LYThMPpplVa...sss..sps.pspc....Vsls.GVpLhVpp.cp..sp.....YpIVRlLS.TsPhcYLc.tapPGppIp....	0	27	44	49
+13878	PF14036	YlaH		YlaH-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O07632	Family	The YlaH-like protein family includes the B. subtilis YlaH protein Swiss:O07632, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a conserved LGFA sequence motif.	27.00	27.00	61.50	61.20	22.70	22.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.67	0.72	-3.90	23	162	2011-05-04 11:58:59	2011-05-04 12:58:59	1	1	162	0	30	97	0	77.20	63	74.91	CHANGED	scssthGhallYlsIllLullVapLGFA+...KLPlLKslllYllLhlGshlLTFhulh..LPlsEuLlVAAllLhIY+lRL	...D.ENPElGMWLLYGsIllLSAlVYNLGFAR...KLslLKNlVIYl.LAlGCTVLTF.FAVF...LPVGEGLVVAAlVLuIYRlRL.	0	9	21	24
+13879	PF14037	YoqO		YoqO-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O31923	Family	The YoqO-like protein family includes the B. subtilis YoqO protein Swiss:O31923, which is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 120 amino acids in length. There are two completely conserved residues (I and Y) that may be functionally important.	27.00	27.00	39.90	39.80	22.90	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.60	0.71	-3.98	8	164	2011-05-04 12:01:38	2011-05-04 13:01:38	1	1	97	0	11	108	1	108.70	49	88.71	CHANGED	p+pIGaYGllhshhlSlllptFhps-hlsh.IlssssFlFlllYsWD-hKsYS+KslllhuIpFlIlluslsFlLhcGpchh-slslFpGWlhlA+llYllhlLslsssIh++Isc+L	..RcKIGaaGhllsh.L.lI.s.FhpsEWls..IlslhshlFs.hYpWD-hKtYS+Kphhlh.hphVlh..hlsFlLlcGpc.h-thshFQtWh..AKhLYllhllhlhhh..lshplsphl.......	0	2	5	6
+13880	PF14038	YqzE		YqzE-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O32020	Family	The YqzE-like protein family includes the B. subtilis YqzE protein Swiss:O32020, which is functionally uncharacterised. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK [1].  This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.	27.00	27.00	29.40	50.40	23.00	22.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.76	0.72	-4.22	19	154	2011-05-04 12:12:15	2011-05-04 13:12:15	1	1	154	0	26	79	0	49.50	58	82.40	CHANGED	psNDYVKahTpphVpYhDpPK-ERKcc....+ptRKppK.Ph.t.RWFGllPhuhpLha	...ssDhV+ahTpphVpYMDsPKE-RKp+....KEpR+s.EKEPF.hs+WFGlhPLShsLaa...........	0	6	16	18
+13881	PF14039	YusW		YusW-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O32189	Family	The YusW-like protein family includes the B. subtilis YusW protein Swiss:O32189, which is functionally uncharacterised. This family of proteins is found in bacteria, and is approximately 90 amino acids in length.	27.00	27.00	29.40	29.10	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.10	0.72	-3.71	19	189	2011-05-04 12:17:32	2011-05-04 13:17:32	1	1	183	0	23	103	0	91.80	45	49.90	CHANGED	hppF-L-l-ap-s..pph-hpYE..ccpsph-Aclc...cthss.phpG-EAhpclcsll.spLslsssssppcllspVlssFsL-p.shpch-l..........ElpFpD	.asEF-L-s-Yp-s..p-YEssYc.ltuspphEAclE.....DcpADlcLpG-EAhsKlpsLL.pcLphcpsTs-...p-Vl-pVlssFpLDc.cYp+F-L..........ElsFoD.	0	9	18	19
+13882	PF14040	DNase_NucA_NucB		Deoxyribonuclease NucA/NucB	Bateman A, Eberhardt R	re3	Jackhmmer:P12667	Family	Members of this family act as deoxyribonucleases [1].	27.00	27.00	27.20	27.00	25.40	26.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.77	0.71	-3.93	29	243	2011-05-04 12:23:46	2011-05-04 13:23:46	1	15	181	0	66	192	1	103.50	50	43.24	CHANGED	lpasss+YP...ETupHIp-.........AltsG..................cucls.TIDRs..uAcppRcpSL+..........shPs+.........pGhDRDEaPhAhscEGGsG....Asl+hIsPoDNRGAGS.lu......................p.QLusas......DGs+lhhhl	............................................................................tFPppRYP...ETupHIpD.....AIp.p.G..................HS.clC..TIDRs.........GAscRRc.SLt..........shPoK.................pGYDRDEWPMAMC..cEGGpG...........Aplc.....YI...oP..uDNRGAGSWVG.......................ppLspaP.......DGT+VhF.l.........................................................	0	12	39	49
+13883	PF14041	Lipoprotein_21		LppP/LprE lipoprotein	Bateman A, Eberhardt R	re3	Jackhmmer:A5U518	Family	The family includes putative lipoproteins LppP and LprE from species of Mycobacterium. LppP is required for optimal growth of M. tuberculosis [1].	25.00	25.00	25.50	25.40	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.79	0.72	-4.05	49	283	2011-05-04 12:39:40	2011-05-04 13:39:40	1	6	143	0	72	185	0	87.80	29	41.83	CHANGED	sssYsss..........upLShlhlp.hssssssss.........ppshhFcpGcalGososcsh......shlssh.tssssslslpYph.t.s-ssssso.GtssVpF+W........ssspl	............................................s.ssasts.......spLShVhlp.sss.uss.sss.........ppslhFHpGpalGouoscsh.......shlssh..tsosDoVslpYp............sp.....t.....sssu.h....hssVpF+W.ssst.h.....................................	0	13	45	68
+13884	PF14042	DUF4247		Domain of unknown function (DUF4247)	Bateman A, Eberhardt R	re3	Jackhmmer:A5U5U9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 143 and 271 amino acids in length.	27.00	27.00	41.80	41.50	26.20	25.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.99	0.71	-4.17	29	214	2011-05-04 13:10:41	2011-05-04 14:10:41	1	1	211	0	35	139	0	171.20	35	83.97	CHANGED	huslhl........shuss............t.sspsaluspYsptus........s..thhhssstosspVAsplsst..ppPssps......s-............................ssshaLRYs....DclVtl.............................................tscstss.................................hIcV-shc.............................................suYpphs.........hhhhus....thssssP....sGusstuu..........GssGuu	..........hhlssAs.....hhluust............ts.sp.Its+YshESss.........ps...hshhssspSsspVAccLlst..pcPpptu..p-................................psphaLhYs....Dc.Ihsl.............................................p.Dtppsss...............................lIclpNhc.............................................usYpshs.........................................h.t..............thTPss.....pGu.hcpu..........GssGu.h............................................................	0	11	21	28
+13885	PF14043	WVELL		WVELL protein	Bateman A, Eberhardt R	re3	Jackhmmer:O31578	Family	This family includes the B. subtilis YfjH protein Swiss:O31578, which is functionally uncharacterised.  This is not a homologue of E. coli YfjH, a synonym for IscX, which belongs to Pfam:PF04384.  This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length and contain a highly conserved WVELL motif.	27.00	27.00	103.30	103.20	20.40	18.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.51	0.72	-4.35	16	169	2011-05-04 13:47:27	2011-05-04 14:47:27	1	1	169	0	20	74	0	74.40	61	86.64	CHANGED	p-hhE+LTspLLEKNspLSYspARTWVELLWpDFEoThAKAG+tYpGp-hTEclVppWI-pYGupLHpapsppsK	.N-haEpLTpELL-KNc+LSYuQARsWVELLWpDFpoTYAKuG+.YQG-EMTEplVRpWIpsHGu+LHchcosNPK.	0	6	12	15
+13886	PF14044	NETI		NETI protein	Bateman A, Eberhardt R	re3	Jackhmmer:O34700	Family	This family includes the B. subtilis YebG protein Swiss:O34700, which is functionally uncharacterised. This is not a homologue of E. coli YebG, which belongs to Pfam:PF07130. This family of proteins is found in bacteria.  Proteins in this family are typically between 42 and 66 amino acids in length and contain a conserved NETI motif.	27.00	27.00	27.00	43.80	22.60	19.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.76	0.72	-4.46	23	336	2011-05-04 13:56:26	2011-05-04 14:56:26	1	1	336	0	28	97	0	51.50	63	91.60	CHANGED	KFcVpENETIu-CLsRMcpEGYhPlRRhEKPlFcEsKcs...plpsh+QcIlF-GKh	.KFcVpEsETIsDCLsRMK.pGYMPV+RhEKPlFpEpK-G...sVEss+QcIlFhGKh.	0	7	15	23
+13887	PF14045	YIEGIA		YIEGIA protein	Bateman A, Eberhardt R	re3	Jackhmmer:P50742	Family	This family includes the B. subtilis YphB protein Swiss:P50742, which is functionally uncharacterised. Its expression is regulated by the sporulation transcription factor sigma-F, however it is not essential for sporulation or germination [1]. This is not a homologue of E. coli YphB, which belongs to Pfam:PF01263.\	   This family of proteins is found in bacteria. Proteins in this family are typically between 276 and 300 amino acids in length and contain a conserved YIEGIA motif.	27.00	27.00	87.60	87.40	18.70	18.10	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.58	0.70	-5.78	25	191	2011-05-04 14:04:51	2011-05-04 15:04:51	1	1	173	0	39	117	0	277.00	56	96.04	CHANGED	hhsllhGllhGslsRlhhL+sDYRQYPTYPHGhlIHluLGhIAAuLGAlAlPALlcc-aTAlTFLuLAApQFR-VRsMERpTLspL-shELVsRGssYIEGIApsFEuRNYlslhTuhlTohshh.hh.........slhhGslsGllshlls+plhpGpplsDIA-lchuclpF.-GstLaV-cIh.IMN.lGLppp+EhlLccGhGhllpPKshs..utsTlsNlGQRQAIlH-lushLGlh+DsspPshsPlu++Dl-sGclulhllP.cpDh-thlcllcplPlLEoAh+hPpctc	......sllhGllhGhhsRlhMLRTDhRQYPTh.HG+lIHIuhGlIAAALGAIAlPulLcK-FoAITFLTLAAoQFRDVRNMERNTLppLDuYELVPRGsTYIEGIAllFESRNYLuhlTSFsTThAYlhFt.........ShlAGlIhulIuhaIu+pLMSGcpL+DlsDIEal.l+F...-GuGLYlDNIY.IMN.IGLPs+QEcIhKaGMGFIL+PKshD..AhlTIuNLGQRQAILHDVSssLGlYRDSGTPuLVPLAKRDL-..DGRVGIFlLPQ-pDsEKAItVItNVPsLESAl+MsoE..t......	0	21	30	34
+13888	PF14046	NR_Repeat		Nuclear receptor repeat	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	This is a repeat domain involved in dimerisation of nuclear receptors proteins and in transcriptional regulation in general. It contains a  Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan  nuclear receptor Dax-1, which represses the constitutively expressed  protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1 [1]. The domain is subject to structure\	determination by the Joint Center of Structural Genomics.	27.00	20.00	28.30	25.80	23.40	19.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.23	0.72	-4.23	14	140	2011-05-04 15:59:12	2011-05-04 16:59:12	1	6	28	0	57	131	0	47.60	54	39.46	CHANGED	FCGEDHPpQGSILYsh.sSAKQTpAA...PEsp.GushWssSCGup+sl	....FCGEDHPpQGSILYshLTSAKQTpuAs.....pAPEAR.GushWssSsGup.s...............	0	4	4	9
+13889	PF14047	DCR		Dppa2/4 conserved region	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis [1]. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	27.00	29.20	27.10	25.60	20.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.46	0.72	-3.69	8	100	2011-05-04 16:17:40	2011-05-04 17:17:40	1	4	27	0	57	74	1	66.80	62	23.52	CHANGED	GhhWCVVHGp..sssscuWltLph.HuGpsaVPsc..G+sIsLFLLPushhPPstlcDNhLCscCV++Nc	.......GsRWCVVHG+sLPADocG.WV+LQF.HAGQAWVP-p..tRhhuLFLLPA........CsFPsPtLEDNMLCPcCl+RNK....	0	4	4	6
+13890	PF14048	MBD_C		C-terminal domain of methyl-CpG binding protein 2 and 3	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 [1] and MBD3 [2], the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex [3], an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	27.00	29.70	28.40	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.12	0.72	-3.40	26	237	2011-05-04 16:22:55	2011-05-04 17:22:55	1	4	92	1	125	236	0	93.50	48	36.94	CHANGED	cs.ssE.llpsh-LscsLpslu.PshsscsLlpulAouL+hsus.....PlsGQssutptl-psPus...hhsssQPLCpthl.....VT-..-DI+cQEc+VppARcRLp-AL	.....................................................t..stE.llcoh-LPKuLps....VG.PGss--.TL.LpulAoALHoost.....PlTGQhou...AlEKNPuV........aLNssQPLC+....uFh.....VT-..EDIR..+QE-+VppsR+RLpEAL....	0	28	36	66
+13891	PF14049	Dppa2_A		Dppa2/4 conserved region in higher vertebrates	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homologue in Xenopus laevis [1], reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	5.00	27.70	14.90	26.00	4.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.94	0.72	-4.14	2	81	2011-05-04 16:24:09	2011-05-04 17:24:09	1	3	20	0	43	57	0	69.70	47	25.78	CHANGED	ppQshPEhS.Es+LQpCSRKtKhVsK+A+L.+ShchpERtEEoNTVEVlTSA.tuMLAuWuRIAARAsQsKulNSpSIPsSVEsFL	.............hst...Es+.......tK......................p........EcsNsVcVhTSA.EAhLASWARIAARAspPcAVsS..........................	0	2	2	2
+13892	PF14050	Nudc_N		N-terminal conserved domain of Nudc.	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics.  NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger [1].	27.00	27.00	28.00	27.30	26.40	25.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.06	0.72	-4.02	60	308	2011-05-04 16:54:57	2011-05-04 17:54:57	1	5	149	0	172	299	1	55.90	41	17.99	CHANGED	p+aDshLhslAppp.sulpshL-shFuFLpRKTDFap.............................G.hp.spsccllhcsFc+	......paDshLLslhQpp.uslpp....hLsshFuFLtRKTDFap..........................................G.hs.GhAEcllhpsFp........................................................	0	66	83	132
+13893	PF14051	Requiem_N		N-terminal domain of DPF2/REQ.	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	This putative domain has been detected on the human DPF2 protein and was subsequently targeted for structure determination by the Joint Center for Structural Genomics (JCSG). Possibly, the C-terminus extends by 30 amino acids and forms a separate domain. DPF2 interacts with estrogen related receptor alpha (Err-alpha), an orphan receptor which acts as a regulator in energy metabolism [1].  It was also identified as an adaptor molecule that links nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa-B) dimer RelB/p52 and switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling factor [2].	22.00	22.00	22.10	22.10	21.20	21.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.34	0.72	-4.05	13	277	2011-05-04 16:55:41	2011-05-04 17:55:41	1	6	85	0	123	214	0	71.30	70	19.10	CHANGED	lsDshY+EslEsussaNoRLshER..RlRhPFLDsQTGVAQscs.tlahppcpRhPGpstGQlYTYPu+RWRK++Rp	.......L.G-paY+-AlEpC+sYNuRLCAER..SlRLPFLDSQTGVAQsNC.YIWMEK+HRGP..G..l.....AsGQlYTYPARpWRKKRR.....	0	24	34	74
+13894	PF14052	Caps_assemb_Wzi		Capsule assembly protein Wzi	Eberhardt R	re3	Jackhmmer:A7UZC7	Family	Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation [1]. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure [2].	27.00	27.00	27.20	27.20	26.80	26.30	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.44	0.70	-5.63	92	390	2011-05-05 12:32:33	2011-05-05 13:32:33	1	2	294	0	143	386	206	444.60	21	90.03	CHANGED	lphhsphGshtus.hsphPhhhpusptslspspsss..................shlpttltpthp.........ttttphp.......................................................................................huhslcs.hshst....ss........................................shplppuYlshphtshtlssGppcph...Gh.......sGuhhhosNARPlPtlplspsp.hsh.s.hhphhhshphphthGhh...ps........s...........chstps..........hhautphhh+.t..p........pLElGlshsstaGGp..............Gp.ss.....uhpsah..cshhutt.t.....st..........s.GNpluuhDh+hph..hhphshtlYtphhhEDpuuhh.h........................tshlhGlchph......hspsphh..lhhEahpTp.pss...................ssaYspshY.sG.apahGpslGssh...........................ssc..spshplGhptp.......hssphshphphsasct.ssh.t........................h.....phtthhcl.....h....hthhst....h....phsushuhcps..phh.ssshshtlslph	................................................................................................................................................................................................................thhsphGshths.hsphPl.hpthtpsLppscss.......................hstlpttlptthss..................thtths...................t................................................h......................................ht............ashtlps..shpts................................................................t.tchpl.p...puYsshp.....hts.h.hlshGphppahGPGh..........sGullh..osNARPhstlplp.psp..hsh.s.hhph.lsshphphshu..ph........ssp.....................phsscs...................hhhut+h.sh..pPh..p........pLElGhsp.sh..paGGc...................Gc.sp.....uh.psah..cshh....upsss.t........t.s....................p.GNpluu...aDh+hph........h.hsh.....slulYtphhtED.......pu..uh.h.t......t......................pshLhGlc.hph.......sppsh....lhhEahsTpspss......tt.................shhYs.H....th.YtsG.atppGhslGssh........................................................sscupshtluhphp.......hssp.p...hpsphpaschsss.t......................sh...pppp.thlpl....tat........hhtth.plpsshhh..sps..p...sss.sh.hth.................................................................................................	0	48	102	127
+13895	PF14053	DUF4248		Domain of unknown function (DUF4248)	Eberhardt R	re3	Jackhmmer:A7V2Q3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 86 amino acids in length.	27.00	27.00	28.60	28.50	26.90	23.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.01	0.72	-4.39	64	339	2011-05-05 12:42:11	2011-05-05 13:42:11	1	1	64	0	17	200	0	68.30	36	86.02	CHANGED	ahlRs.Ys+sELAhhYhP.....sl.ss.puAhc+LpcWIcts.tLhppLttsGYpppp+haTPtQVplIlcaLGEP	.......a.l+s.Ys+sELA.thYhP.....sl.sspsAhc+Lp+WIcts.sLhppLtssGYpsps.+t.aTPtQVplIschLGEP....	0	8	15	17
+13896	PF14054	DUF4249		Domain of unknown function (DUF4249)	Eberhardt R	re3	Jackhmmer:A7V6V4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 279 and 365 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	27.00	27.00	27.20	28.20	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.95	0.70	-5.06	80	352	2011-05-05 13:08:51	2011-05-05 14:08:51	1	2	162	0	154	373	218	287.50	17	90.65	CHANGED	hhhllhhhhh..suC...pc.l-l.shsss.s+LVlsuhls......sssssttlpLoposshhssp..........lssApVpl.......sssptpshhhtpsss........................shYh....sss..........hspsGcsYpLplph..stpphsApsplstss.sl.pslphpptshhsspp.pp.....................lplpapDss.sppNYYhhphp.pph.hh.........................................................................................tlhsDphh.........sGpphshthhhp..............................phpsssplplplhulocshYpYhpsl.ptpsss.....ss.hhstPsslhuNlhsu...................lGhFussphs.phphpl	............................hhhhhhhhh.suC...pc.l.s.h.p....hsss...spLVlpuhls................ssssthlpLopo.....tsh..hsst..........................lssApVpl............................hssptpphhhtpsst.................................stYh...........sssh.................thpsGcsYpLpl.....ph..st....pph.sA.p.s.p.lstss...tl..pslp..hp...thhs.tt.t......................hplshpDss...spp...sYY...hhp.hp.pth.h...............................................................................................t.h.........................lhsDp.hh..............sspp.hp.hth..t..............................thphtt.pl..tlchhulocphYpYhpsl.thpsss.........................st.h..stPspl...uNlpss......................lGhhsssshs.ph.h..h........................................................................	0	77	140	154
+13897	PF14055	NVEALA		NVEALA protein	Eberhardt R	re3	Jackhmmer:A7V7L0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 92 amino acids in length. There is a conserved NVEALA sequence motif.	27.00	27.00	27.10	27.20	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.46	0.72	-4.27	65	219	2011-05-05 13:17:48	2011-05-05 14:17:48	1	1	44	0	36	174	0	71.20	26	84.01	CHANGED	K.....p..Klhhhhhhusl.sshsGashhps...pptc.....thS.DLuLsNVEALA.sGEss..............s...............................stsshsC	..............phhhhhhh.uhl....sshsuhshhps....pptc.....ph.S..-LsLsNVEALA...suEss..................................ss................h..C....................h...............................................	0	6	19	36
+13898	PF14056	DUF4250		Domain of unknown function (DUF4250)	Eberhardt R	re3	Jackhmmer:A7VAD8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are two completely conserved residues (N and R) that may be functionally important.	27.00	27.00	30.10	37.20	25.40	21.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.60	0.72	-4.24	92	470	2011-05-05 13:27:41	2011-05-05 14:27:41	1	1	362	0	66	290	8	55.00	43	87.76	CHANGED	lshD.....Ph.hLlShlNhKLRDpas.SL-pLCpshslsccpLhpKLsslGYcYctppNQF	..............shDPh.hLhSllNhKLRD.-.as.oLDcLsssa-lDccpLh...sKLsshGacYssppNQF....	0	19	37	53
+13899	PF14057	GGGtGRT		GGGtGRT protein	Eberhardt R	re3	Jackhmmer:A7VAK6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 330 amino acids in length and contain many highly conserved residues including a GGGtGRT motif.	27.00	27.00	46.00	46.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.07	0.70	-5.62	11	294	2011-05-05 13:44:32	2011-05-05 14:44:32	1	2	279	0	48	216	16	313.70	78	97.84	CHANGED	pFEuh-RRhs+IptsLpphGlsSLE-ApplCps+Glcs.pIV+slQPIAFENAsWAYTLGsAlAlK+GspsAu-AAttIGEGLQAFslPGSVADpRpVGLGHGNLuAMLLpEETcCFAFLAGHESFAAAEGAIGIApsANKVRKpPLRVILNGLGKDAAhIISRINGFTYVcTpaDYhTGELclVcE+saSsGs.RAtV+CYGADDVcEGVAIMp+EsVDVSITGNSTNPTRFQHPVAGTYKKtslEpGKcYFSVASGGGTGRTLHPDNhAAGPASYGhTDTMGRMHuDAQFAGSSSVPAHV-MMGLIGMGNNPMVGATVAlAVAVppA	......................h.FESa-RRIcpIpssLsphGIpo....IEEApplCcstGlDsYphlcphQPICFENAsWAYslGuAIAIKK....GC....c....sAA-AApAIGcGLQAFCIPGSVADpRKVGLGHGNLuAMLLcEETcCFAFLAGHESFAAAEGAItIAcpANKVR..KcPLRVILNGLGKDAApIISRINGFTYVpTpaDYhTGE.....LclVpcpuYSs...G.......RAKVpCYGADDVREGVAIMa+EGVDVSITGNSTNPTRFQHPVAGTYKKEplEpGKcYFSVASGGGTGRTLHPDNMAAGPASYGMTDTMGRMHSDAQFAGSSSVPAHVEMMGhIGMGNNPMVGsTVAlAVuVpEA...	0	26	43	45
+13900	PF14058	PcfK		PcfK-like protein	Eberhardt R	re3	Jackhmmer:A7V2F8	Family	The PcfK-like protein family includes the Enterococcus faecalis PcfK protein Swiss:Q82YK9 which is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 137 and 257 amino acids in length. There are two completely conserved residues (D and L) that may be functionally important.	27.00	27.00	33.20	32.90	24.40	23.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.85	0.71	-4.04	18	325	2011-05-05 14:36:51	2011-05-05 15:36:51	1	1	168	0	19	230	7	125.50	39	76.36	CHANGED	K.uo-pFKcsIpsYLppRApsDpLFAtsht+ssKNl--ClsYIlscVp.....+...oGss..........uhsD-ElauhAl+YYc..EcsIcssK.slpCpV......sVN+h...lphotccKtcs+ppAhcphppEchpKhpp+spts+.....ttscs...psQ.SLF...Dh	......................so-pFpcsIppYLspRAppDtLFA.shh+ssKsI--ClTYIlsplp......c.......uGCs..........GhsDsElFuhAlHYY-..E-cI-lGK.sls.CpV...............sVNHh...lcLTpEEK....scARppAlcphppEphtKhppcpt..t..........t....p.oLF.....................	0	8	17	19
+13901	PF14059	DUF4251		Domain of unknown function (DUF4251)	Eberhardt R	re3	Jackhmmer:A7V8X1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 196 amino acids in length.	27.00	27.00	30.40	29.80	26.70	26.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.59	0.71	-4.36	50	228	2011-05-05 15:01:04	2011-05-05 16:01:04	1	1	117	2	32	178	4	144.00	26	81.10	CHANGED	s+ppp+pp..................ptpplpphlsscpaplcsspshP...................ppGpsh.Ls.ss..hlplpsDolhspLsa..aGpsas.sPh...GpGulsapushpsaphp.pcKKGshplshsspsp..tps.hphslslassu.sAslslsss.s+psl.....oasGplt	................................t.....ttt..................thppstptlcscpahl-sspsh....................hpGpshhlo.ss..hlplps-pshsplsh..FspsYs.sP....GhGulshsushss..hphp.h-KKGs.hp...l.shslpsh...t.s...hphplslhssu.sAolslsss.sppsl.oasGpl.h..........	0	12	26	32
+13902	PF14060	DUF4252		Domain of unknown function (DUF4252)	Eberhardt R	re3	Jackhmmer:A7VAG1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 182 amino acids in length.	27.00	27.00	27.90	28.80	24.30	26.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.90	0.71	-4.67	82	269	2011-05-05 15:12:56	2011-05-05 16:12:56	1	2	129	0	88	266	42	153.50	18	87.94	CHANGED	Kph......hllhh.lhlsshsutu................t.t.phas....capstcshsslslspphhphhsph...........p.cspphtchlpplcslplhs.ts............sp..spsphppphpphhp.....s.sacpLhplp...-.ssppsphhh+tsps....tlpElllhsss.................cp........phsllpltGs.hs.pclsplhpp	........................................h..lhhhh.lhlhsh.hstu................t.p.phFs....ca.pcpcslssVtlsppMh.phhsph.............ps.ph.tplhpplcslplhshpc..............sp........hppphppphpplhp.......s.sappLhphp....-.psppsplhh+tpts....tlpElllhsss.................cs.phsllplpGc.hs.p-ltplht.........	0	34	74	88
+13903	PF14061	Mtf2_C		Polycomb-like MTF2 factor 2	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Domain	Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression [1]. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	27.00	27.00	29.90	26.90	26.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.60	0.72	-4.07	11	173	2011-05-05 16:17:15	2011-05-05 17:17:15	1	3	65	0	92	157	0	48.60	61	8.25	CHANGED	ssshscL+sSlssYFGuA.GRlssGE+apVLARRVTs-GKVQYLVEW-Gsss	......s.pLsHLKsSIosYFGAA..GRlAsGEKYpVLARR.VTs-GK...VQYLVEWEGsT.....	0	12	19	43
+13904	PF14062	DUF4253		Domain of unknown function (DUF4253)	Bateman A	agb	Jackhmmer:C7PV89	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.	27.00	27.00	33.60	33.30	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.32	0.71	-4.43	58	204	2011-05-05 16:42:08	2011-05-05 17:42:08	1	17	177	0	57	196	2	108.70	32	25.08	CHANGED	shhlshlPspcsa-lhuhls.h.GuhNpsssssphsAlh+tWp-+aGuhlsulshD.pl-hhlsp....PPtstc-AhplAtEpatFCsDhlcQ...s...............ht..olpsLA.ctLhpsphWaFWW.....D	..................................t.hlshlPsppsa-lhuhls..h.GuhNtsssss-hhAlh+hW.-+aGAh.ssls.a.D.pl-h.lsp....Ps.s.-cAhplAhEpYsFC.PDhl-Q...u................................ht..olppLA.c.sLh.psptWaFWWD......	0	21	46	55
+13905	PF14063	DUF4254		Protein of unknown function (DUF4254)	Bateman A	agb	Jackhmmer:C7P9Y0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 195 and 207 amino acids in length.	27.00	27.00	27.10	27.10	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.64	0.71	-4.59	56	245	2011-05-05 16:45:14	2011-05-05 17:45:14	1	4	231	0	90	244	323	136.60	40	65.79	CHANGED	ltpllhppshhcshpWHhEDlhRcsslsstthhphKRpIDt.NQcRsDhVEhlDsahLpthpsltshs..sA..........plNoEoPuhslDRLSILuLKlYHMp-pspRpD..As.tpHhtpCppKLslLhEQ+sDLusulDpLLsDltsGcKhhKV	.................................................h.tthlah+shl-ssQWHhEDllRcPplss.tshthKRcIDp.NQ-RoDhVEhIDsahhpthpslpshs.....sA..........plNTESPAhulDRLSILuLKIYHMp-pspRsD...ss...s-HhtpCppKLslLhEQ+tDLupAl-pLLsDltsGcKhhKV......	0	34	71	87
+13906	PF14064	HmuY		HmuY protein	Bateman A	agb	Jackhmmer:C7PU21	Family	HmuY is a novel heme-binding protein [1] that recruits heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR.\	   This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 278 amino acids in length.	27.00	27.00	30.60	27.10	25.20	26.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.27	0.71	-4.24	83	274	2011-05-05 16:52:52	2011-05-05 17:52:52	1	4	165	4	92	262	99	176.90	20	72.01	CHANGED	sstssahYhshcssph.........................................................h.ttpttpsssWDlAFpph...slpsNuGs............su.Gpstshh.hs...........................ssasp...........ssshsssssatt..D............................................................................................t.......hshstshssssh................................................................................suWasashs...........................................................................sshhsspsp.lall+s...s-.GpasKlplhsaYssss..................uahoFcYt	.........................................s...spWhYhshpssph........................................................................................t...tpttpsssWDl..AFpph.........pl+sNuGs..........................ts.utstsh....ss.............................sshst.................ssptsssssass...D.........................................................................................................................h.hst....t....hsht.t.shsstth...................................................................................................................................................ssWhshshs...........................................................................sshhssstp..lall+s..........s-..GpYsKlplhsa..hssss..tp..............uhhohpa.........................................................................................	0	37	67	87
+13907	PF14065	DUF4255		Protein of unknown function (DUF4255)	Bateman A	agb	Jackhmmer:C7PSC6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 320 amino acids in length.	27.00	27.00	30.40	29.90	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.97	0.71	-4.83	82	228	2011-05-05 16:56:58	2011-05-05 17:56:58	1	5	188	0	126	237	37	182.90	19	72.26	CHANGED	lstlspsLpsh.Lppthtt.............ssspVsh.ssPsp..........ssttsssplslaLaplpcssth+sts...stpsstt.......hhps.slhlsLaaLloAa..........ssshtpshpl...Lupslphhppp.shl...stpshssth.................................................tthp..plplph.s.hsh-plsclWusL.ssp.apPSlsYplshlhlpssthtsts....sVsphs	..................................lttlspsLpph.Lppth.t.............ssspVsh..ssPsp..........sstt.sssplslaLaslpcssth+spsh.......psspst........hppP.PhhlsLpYLloAa.............spsstpptpl........LupslphLtpp.shl...sspslssth.................................................ttht......tl.p.lt.h.s..hshcplsplWsuL.ssp..h+sSlsYplsslhhtssthts.s..Vtp..s.............	0	38	92	115
+13908	PF14066	DUF4256		Protein of unknown function (DUF4256)	Bateman A	agb	Jackhmmer:C7PN24	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.	27.00	27.00	203.50	203.40	22.20	19.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.02	0.71	-4.77	44	212	2011-05-05 17:00:08	2011-05-05 18:00:08	1	1	211	0	53	180	13	172.10	67	92.09	CHANGED	LLpsLKsRFEcNhpRHpulcWspVps+LcAss-KLWSLp-MEcTGGEPDVVuaDpposcYlFaDCSsESPKGRRSlCYD+cAL-uRKcaK..PcssAl-hAspMGIELLTEEQYRpLQpLGpFDhKTSSWlcTPssIRcLGGAlFsD+RYspVFlYHNGA-SYYAuRGFRGhL...+V	.LLclLcsRFEKNMsRHc..GL-WucVpsKLps.s.sEKLWSLsEMEtTGGEPDVVuYDc.cp-EYhFaDCStESPKGRRSLCYDtEALESRKcHK..PcNsAIDhAssMGIELLTEEQYRpLQpLG-FDhKTSSWlpTPs-IRcLGGALFCDhRaG+VFVYHNGA-SYYAARGFRGsLRV....	0	30	45	49
+13909	PF14067	LssY_C		LssY C-terminus	Eberhardt R	re3	Jackhmmer:Q7UW88	Family	This domain is found at the C-terminus of Legionella LssY proteins, which may be a part of the type I secretion system [1]. This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 182 and 195 amino acids in length. It is often found in association with Pfam:PF09335 and PF01569. There are two completely conserved residues (P and W) that may be functionally important.	25.00	25.00	25.10	27.10	21.70	24.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.14	0.71	-5.32	48	217	2011-05-06 08:39:08	2011-05-06 09:39:08	1	5	202	0	75	233	29	174.90	23	33.97	CHANGED	hs.pthhhcthPspopshDGh..uDPlNlsll.GspsplpsshtpsGWptscshohpo.hphshuslhcpshstAPVSsLahhGRtQDhAaQp.ssssstp...RaHlRhWpssht..................stssp........shWlGusoaDpGlth.ohhospl.o.HcI-s-lDsERDtlhpslp.tss.httsthhtshsss.....thssss-sahTDGcl	..........p...hp.thphhPspppshsGp..tpPlNlths.Gs.s.tlppthpttGWppssphohps...hlthhhhppshsphPV.shhhpu+spslsht+.sss.ss.p...RphlRhWtssht..................htssp........slWlGuhsh-phh...shhtt.l..h.atht.shD..thshlhttl.........................................................................	0	25	43	59
+13910	PF14068	YuiB		Putative membrane protein	Bateman A	pcc	Jackhmmer:O32109	Family	This family of bacterial proteins is functionally uncharacterised.  Proteins in this family are approximately 100 amino acids in length. There is a conserved FGIGF sequence motif, and many members are putative membrane proteins.	27.00	27.00	43.70	30.40	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.46	0.72	-3.70	21	172	2011-05-09 08:23:49	2011-05-09 09:23:49	1	2	165	0	33	112	0	95.60	60	96.48	CHANGED	s.llIShlLFFVLFFGIGFlLNMLLRtTWlMAllYPIVllhIlsp.thhpYhpsPupuFsulhcclhuLthsDllILsuGhsGAllSGhsI+hLR+pGYQMF	..........llIuMhLFFlLFFGIGFLLNMlLRsTWlM.sllYPIVClhIIs+sshhcYFocPpEoFuShGspVupLutADlhILSoGLlGAhlAGllIKpLRKsGYQMF..........	0	11	24	27
+13911	PF14069	SpoVIF		Stage VI sporulation protein F	Bateman A, Coggill P	pcc	Jackhmmer:O31625	Family	The sporulation-specific SpoVIF (YjcC) protein of Bacillus subtilis is essential for the development of heat-resistant spores. Its expression is governed by SigK [1,2].	27.00	27.00	28.30	28.20	23.00	22.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.42	0.72	-4.24	18	195	2011-05-09 08:36:16	2011-05-09 09:36:16	1	1	170	0	38	106	0	78.90	49	91.38	CHANGED	FcslcKKTu..Vs.p-lhKLAsSlpsANhcDEpsVRplI+pVuplAN+PVoKEpEDcIVpAIhsssh.stDhsoLsKMh...KK	.....FsNIEKcsp..VNc-DIFKLAuSVQNANL+DEsslRQLI+pVAhhAs+cVPKEpEDpIVcAIlsssh.PsDFuoLuKMhp..K......	0	10	26	28
+13912	PF14070	YjfB_motility		Putative motility protein	Bateman A, Coggill P	pcc	Jackhmmer:O34438	Family	This family of proteins is regulated in B. subtilis by SigD, and is likely to be involved in motility or flagellin production, Proteins in this family are approximately 60 amino acids in length, and contain two highly conserved asparagine residues.	27.00	27.00	27.10	27.00	26.50	26.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.67	0.72	-4.18	64	334	2011-05-09 08:54:15	2011-05-09 09:54:15	1	1	320	0	92	221	9	58.30	30	94.26	CHANGED	Iuulus.....uhupsphtpp.luhuVhKpuhDspppsutpllph.......h..........t.ussPslGp.slD..................lps	.................huMupupLhps.VshoVLKKuMDsscshh.spLlcs.......h...........ttuspsshGs.slDlhA.....................	0	34	66	78
+13913	PF14071	YlbD_coat		Putative coat protein	Bateman A, Coggill P	pcc	Jackhmmer:O34880	Family	This is a family of putative bacterial coat proteins. Proteins in this family are approximately 140 amino acids in length.	27.00	27.00	65.00	64.80	26.70	20.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.69	0.71	-4.06	18	144	2011-05-09 09:44:54	2011-05-09 10:44:54	1	1	143	0	20	87	0	127.50	56	91.84	CHANGED	ccFKpFV++HPKlIpEVRpGpKTWQ-lYE-WhLhGEDDchWssY+...............tpssspcpc.........pppps-hhsplhshlK+hDssplQpalsphSpuIuulQsllsQFpssspppt.......tptpp.PFSFRKD	.pQFKEFVp+HPKhl+EVRuG+KTWQQFYEEWYLLGEEDPIWssYR..................tp.tEscccp-s.+sE.................EEKouDlMGQMLSahKKLDV-QMQcHLANVoSAIGSVQQVlQQFQGs+oQQc......psoSEsNPFhFpKD............................	0	3	12	14
+13914	PF14072	DndB		DNA-sulfur modification-associated	Bateman A, Coggill P	pcc	Jackhmmer:O34448	Family	This is family of bacterial proteins likely to be necessary for binding to DNA and recognising the modification sites.  Members are found in bacteria, archaea and on viral plasmids, and are typically between 354 and 474 amino acids in length. There is a conserved DGQHR sequence motif.	29.00	29.00	29.00	30.30	28.50	28.90	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.10	0.70	-5.31	64	426	2011-05-09 10:06:35	2011-05-09 11:06:35	1	2	328	0	110	399	165	326.50	18	79.94	CHANGED	aPAl+GhQus+..............paYhshhPh+hl...s+lhhhsp.p..phssphR...........................uQR............sLNcsRlscIscYl.lp.........................N.p..sYl.huul.Tusls...s.shthp...h...............ttts..t.plGhLpls..hDu.c....hhlsDGQHRpsAIc.......pALc......csP...p.......Lup-..............sIuVlha....h-tuLc+sQQhFuDlNptuh+sssSls............hhYDcR-.s..hutls+plh.....ppsshap...shs-hccssluppup+LFT.lsslhpusptLh....................tptttsph..cpttphsppFWptl.spphs-...Wp.lhppphss......tphRpchlpupulsLpAlGhhupt..........lhppt.........spphcptlptLpp....lDWs+ss.......W.....ps...+sh..psp.................lsps..psslpLssstlcptlulsLs	...........................................................................................shph.p.s.t.t......ha.hhh.hp.l....clh.hsp.....p......p.s.p.t...............................hQR..........................slsps....+l.p.c..Itc.Yl....p................................................................................stp.......shl...hs.sl.shshs....t..thphp.....h..............................................tssshGhLpls........cs..p.................hhllDGQHRhtAlp.................................puht.................................p........p..........................lsp..........................................plsVh..ha.................hs.shcc.p.pp....h..FhslNppthhsssslh..................................h.hsp.cc............shlsppls.................pts.ht...............shhc...h.t.....p.....s...s........tpp..ptlh........o..hssl.hph..hp...thh.............................................................sttp.tphhp....hhppaaptl..tphhst......hp.......................................p....p.h.h.h....p.s....h.hh.slu.hh.t.........................h.......................................................................................................................t.......................................................................................................................................................................................	0	27	75	97
+13915	PF14073	Cep57_CLD		Centrosome localisation domain of Cep57	Coggill P	pcc	manual	Domain	The CLD or centrosome localisation domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component.  This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, Pfam:PF06657, is the microtubule-binding region of Cep57.	27.00	27.00	27.40	27.20	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.26	0.71	-4.44	8	162	2011-05-09 10:19:16	2011-05-09 11:19:16	1	3	48	0	73	143	0	161.50	53	39.03	CHANGED	AllSALKsLQEKIRRLELERsQAccslppLSREusca+csL....................cc-ppp+shtpp-hopp.........pp-lspQLsuAEuRCoLLEKQL-YM++MVcs.s-+E+sslhEpQspLpREppppQhclpupLcKL-lLEpEapRLTsTQusAEcKIppLEcKLpEEEpQRKLhQDKAucLQTuLEsN+lll	...........................Alh.ALKsLQ-KI+RLELERhQAE-sl..ptLS+Es....hp.YK..KsL....................-...p...php.ERp.u+pE..Kp...............pp-ls.QL.uAps+CsLLEKQLEYh+pMlhp.sEtE+shlLEp.Q.spLpRE+...p........p.DQh+.l..pupLEKLDlLEpEh.+LTshQthAEcKhpcLEpKL+EEEppRKhhQcKA.upLQTGLEhs+llh..............	0	13	18	34
+13916	PF14074	DUF4257		Protein of unknown function (DUF4257)	Bateman A	pcc	Jackhmmer:O34881	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	27.00	27.00	30.20	30.80	26.30	25.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.67	0.72	-4.33	11	133	2011-05-09 10:32:23	2011-05-09 11:32:23	1	1	114	0	10	61	0	80.20	64	70.66	CHANGED	plllAslIGGlhGlluH.lpp+G+lphP..........................................Rp.....s+phaalGFltDhhlGhhAulLhV.lhs..cspohhpllhlSIluGlGGEuhLhS	..QWLTAlLlGGITGFVSHLINN..QGKLLLP............................................RR.....LKTFFHhGFLTDIFTGSLAALLGL.VLF..DVTsIKEIIKVSIVTAISGQTFLLH.	0	1	4	5
+13917	PF14075	UBN_AB		Ubinuclein conserved middle domain	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone  complex involved in the formation of a certain type of facultative  heterochromatin, called senescence-associated heterochromatin foci  (SAHF) [1] [2]. The domain described here is conserved in many  eukaryotes such as human, rat, drosophila, and zebra-fish and has been  targeted for protein structure determination by the Joint Center  for Structural Genomics.	25.00	25.00	25.00	25.00	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.48	0.70	-4.66	12	163	2011-05-09 11:56:05	2011-05-09 12:56:05	1	5	79	0	96	141	0	196.10	46	21.34	CHANGED	LPpsLsscllpplsslK-hu+.h.chsG+ppFF-sclssLLLclt.phppss..pstRstVapHLEtpLpssK.slh++hKpl+lccpcs+hppsLpKL+cAlscsMPctlssYEhEppphsptpsu..................cpsuEc.P.....ph+hPRKKFpWs-plRpLLhclhpl+hpSatl.t.pRppShE-alpu...aLcpcVhsLWPpGWMphcpLpKEl	................................................LP-.GLPs.Lc++lc-Lp...........AA+hh...-tEG+pKF.Fop-hNslLLDIElQhp..Els....stlRSuVYuHLtuFlPCsK-oLlK....Rh.KK....L...+L...................p.....Q....c.s..RL+EPLpKLK.AlupsMPEQlt+Ypc-CpA+spsKsA.........hpt-.p-.cpp.....................s-.--D-E+ss.......+RlhGPR.....KKFpWsDpl.RpLLCplVclKLtsY-LEt.s+u.......pShED....alKs...........Fh-........s....EVKPLWPK.GW..MQuR.hLaKES................................	0	28	35	57
+13918	PF14076	DUF4258		Domain of unknown function (DUF4258)	Bateman A	agb	Jackhmmer:Chitinophaga pinensis 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 95 and 124 amino acids in length.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.25	0.72	-3.97	112	331	2011-05-09 12:23:19	2011-05-09 13:23:19	1	5	278	0	128	317	58	71.80	19	55.93	CHANGED	hhop.H.Ahpchp..pRp.Ishp-lhpsl..tp.Gclhcphs....sst.tssplhlttstppt............slcllhshsps.....hhhllTlahs	...................hopH.Ahp+hp...cRs..Ishpplhpsl....pp..Gclhct.........pst.tss.phhhthstttp..................lpllhshpps......hhllTsa......................................	0	56	95	118
+13919	PF14077	WD40_alt		Alternative WD40 repeat motif	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	WD repeats are short subdomains of about 40 amino acids and fold into 4 antiparallel beta hairpins. This domain here has been detected on the C-terminus of WD repeat-containing protein 18 during target selection by the Joint Center for Structural Genomics.	25.00	25.00	38.30	64.70	24.30	21.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.27	0.72	-4.33	4	42	2011-05-09 12:27:19	2011-05-09 13:27:19	1	5	31	0	22	35	0	47.50	63	11.27	CHANGED	huush-KslhGst-pL+lRVuELEEEVRsLRKIN+DLFDFSTRIIT+P	..hsooh-KsVLGsQ-pL+lRVoELE-EV+sLRKINRDLFDFSTRlIT+P...	0	1	3	7
+13920	PF14078	DUF4259		Domain of unknown function (DUF4259)	Bateman A	agb	Jackhmmer:C7PLU1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 118 and 145 amino acids in length.	22.70	22.70	24.10	23.40	22.30	21.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.73	0.71	-3.64	61	249	2011-05-09 12:29:06	2011-05-09 13:29:06	1	6	214	0	67	189	4	121.80	20	66.43	CHANGED	GuWuhusF-sDsuhDhls-Ltct.............thhpthhcsshhs..tspchl-s--stsuluuAtllshh..........hsssh.ssthtt.............................ttpssppltphAhphlcplhst...SEhh-LWp...ps..tth-pWhpslp	.....GuWuhthF-sDsuhDhlsplp-h.............ttpthlpth...tpthhhs...tttsth-hc-s...t...s...sluhAtlhhth..........t.sssh.sss..h.t.............................htph.ppltphshphlcph.t........tt.hphW.p.........h.t.......................................................................	0	18	51	67
+13921	PF14079	DUF4260		Domain of unknown function (DUF4260)	Bateman A	agb	Jackhmmer:C7PFK4	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 126 amino acids in length. There is a conserved GLK sequence motif.	27.00	27.00	32.20	32.00	26.40	24.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.56	0.71	-4.26	24	197	2011-05-09 12:52:38	2011-05-09 13:52:38	1	1	193	0	65	166	5	108.60	44	92.15	CHANGED	sctllRlEGhslhssulhhYuhhs..huWhlahlLlLsPDLSMlGYLhGsRlGAhsYNhsHoahhPllLlslGlhhssshs........htlulIWlAHIGhDRhLGYGLKYssuFccTHLGRl	......................+tll+hEshslh.lhslhhYs..h..hp..aS.W...hlFhlhlLsPDLSML.....uY.hhss+lGAh......lYNlhHoYllslllsllGlhhp..shl........lhlu.LI..WhAHIGhDRhhGYGLKYp.ssFcpTHlt+l..........	0	20	46	55
+13922	PF14080	DUF4261		Domain of unknown function (DUF4261)	Bateman A	agb	Jackhmmer:C7PC06	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length.	27.00	27.00	27.30	27.30	26.60	26.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.50	0.72	-4.17	52	353	2011-05-09 12:56:15	2011-05-09 13:56:15	1	16	297	0	40	258	2	77.10	31	21.46	CHANGED	hThGhpsFsh.-lphh...pshcsp-lhpaLhslutYllppsss.lp-G-TI.Ghss......ppphphptppu.....lts..sp.s.LcIp	.........YThGhcsFsc.ElElps...tsh-sp-lh..hlhslshYlLppDss.LcDG-Tl.thp-.........spphphpcspu.....lts..ppts.LcI............................	0	21	29	34
+13923	PF14081	DUF4262		Domain of unknown function (DUF4262)	Bateman A	agb	Jackhmmer:Q50763	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 147 and 227 amino acids in length. Swiss:Q50763 is incorrectly annotated as the KatG protein.	27.00	27.00	30.00	29.60	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.75	0.71	-4.01	54	189	2011-05-09 13:06:11	2011-05-09 14:06:11	1	2	171	0	54	153	10	117.50	29	65.65	CHANGED	pltcpGhslhtVhscppsss...........aua.olGh.pphshPEl.llhGL.shphspshls...plsptht.tsc...h......Gtthpph.......tsh.shhh.lt...ht..hhh.u..hat.............h.slQhlasDtpGhh.......PWc.shs	......................lhpaGWslhtV.s-cps...............auYTlGL.sphshPEL.llhGL.sschupplLNthucc.hh.sGch...hssGhphsth.........ts....lthhpVspschc...hhhA.hhhat...........sph..sLQllWsDpcGpa.......PWpssh.........................................	0	17	40	52
+13924	PF14082	DUF4263		Domain of unknown function (DUF4263)	Eberhardt R	re3	Jackhmmer:Q7UE31	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 244 and 403 amino acids in length.	27.00	27.00	27.70	30.50	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.04	0.71	-4.29	61	136	2012-10-11 20:44:47	2011-05-09 14:08:03	1	3	127	0	43	141	11	162.50	19	47.31	CHANGED	Lpss...t............sEppaQphlcps.shlh...shtasthh...........hh.schp...hssphhsDFlhhstssshh.......llEIKpPs..pslhsp..........ssh...t.up-lspAlsQlhcaht.hlppptsphptptptt...........................shps+slllhGcp.........phhsppppcshchhppph...t.slcIlT...aD-Ll	........................h.....t...sEpphQpahcps..shlh......uhtast.h...........hhh...schs.......hssshhsDalhhstssshh.......llElKpPs...spl.hpp...........ssh..........t.ut-lspAlsQlhsaht.hlppphsthptp.pht..............................shpscshllhGpp.........p.hsppp.pcsh.chhppph....t.plpllTaDpLl..............................	0	15	31	39
+13925	PF14083	PGDYG		PGDYG protein	Eberhardt R	re3	Jackhmmer:Q7UEH4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved PGDYG motif.	27.00	27.00	27.40	30.30	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.59	0.72	-3.65	6	78	2011-05-09 13:16:29	2011-05-09 14:16:29	1	1	76	0	24	63	18	101.70	77	69.33	CHANGED	GP...............NRYtPGDAllTGuTGDRWVVSR-RFDs+Y.shsPs.sHGcsGAYRN+P.lsVLA+cMscsFsIARSs.GGDVL+GssGDWlMQYA........PGDYGllppARFupVYR	.................GPNRYssGDALlTGSTGDRWVVSR-RFDAKYlPsssuhAHGpPGAYRNRP.AVVLA+RMDtPFoIARSA.uGDsLRGsAGDWVMQYA........PGDYGVVQApRFAQVYR.	0	3	7	15
+13926	PF14084	DUF4264		Protein of unknown function (DUF4264)	Bateman A	pcc	Jackhmmer:P54395	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	28.70	28.60	19.80	18.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.31	0.72	-4.59	25	183	2011-05-09 13:37:37	2011-05-09 14:37:37	1	2	183	0	47	86	0	50.80	62	89.49	CHANGED	KlElluohchppscDhYKlVDFLN+TLK-cslhFGLohspc.....cschlhoIYcT	.KIElLuThclchosDLYKIVDsLNRTLK-pcLMFGLALDEc....c+cpAVFTIYRT.	0	22	36	40
+13927	PF14085	DUF4265		Domain of unknown function (DUF4265)	Bateman A	agb	Jackhmmer:Chitinophaga pinensis 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 139 and 168 amino acids in length.	27.00	27.00	28.00	34.10	25.40	25.30	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.13	0.71	-4.35	42	117	2011-05-09 13:38:35	2011-05-09 14:38:35	1	2	102	0	45	106	14	114.70	24	73.85	CHANGED	sEslauc.hls..ssp.aclpssPaashulAhGDllpsppss..tthhhpch.ttuGssTlRlhh.pss.........hpplhsplpthGssh-shpt..shlulslPspsshpslpphLsp.hpcpshlpa	.........Etlaup.hhs..ssp..atlpslPaas.slAhsDllphcpcc..thhhhpcllpsSGNsTlRllhhspt........hpplhsp.lp.p.hGsphEt.st..shlulslPspsshpslctlLsp.hc-pshhta............	0	18	22	33
+13928	PF14086	DUF4266		Domain of unknown function (DUF4266)	Bateman A	agb	Jackhmmer:C7PCX1	Domain	This presumed lipoprotein domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 50 amino acids in length.	27.00	27.00	39.50	39.50	25.10	25.00	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.47	0.72	-3.45	47	129	2011-05-09 13:43:10	2011-05-09 14:43:10	1	1	108	\N	61	131	37	49.90	44	58.12	CHANGED	VpPaE+shLAcs-Msh.spcshcsshspHlY.u+Euu.uGGtGhuGGGCGCN	.VcPaE+spLAcs-MsL.spcshctthspHlY.s+Euu.uGupGhuGGGCGCN.	0	21	45	55
+13929	PF14087	DUF4267		Domain of unknown function (DUF4267)	Bateman A	agb	Jackhmmer:C7PBL0	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.	23.00	23.00	23.50	25.10	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.30	0.71	-4.48	58	194	2011-05-09 13:46:48	2011-05-09 14:46:48	1	5	140	0	133	197	3	111.20	22	73.37	CHANGED	hushhlshGlthllp.PppAhshFGl.......Pts........................pptssuh....hhlhGsRDlshGlslhshhhh...............ust+ulGhhl...................lusuhlsluDuhlshp...........tGssttsh...Hhs.....husllsshGhllh	..............................uhhhlhhGlth.lhs.PttuhttFGl.....Ptt......................................................................pssspuh....htlhGsRDlshGlhlhshhht...............uph.cslGhhl...................lssuhlsluDshlshp..............tus.ttts.hh..Hhs.....suslhhshuhhh.h............................	0	31	77	114
+13930	PF14088	DUF4268		Domain of unknown function (DUF4268)	Bateman A	agb	Jackhmmer:C7PAS6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.	27.00	27.00	27.30	28.50	24.90	26.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.68	0.71	-4.52	63	189	2011-05-09 13:50:04	2011-05-09 14:50:04	1	8	179	0	68	194	80	136.50	22	45.35	CHANGED	pl+p.cFWpphhcphpt...............tshps.scpWlshso.Gl.puhshphhh........spc..cspVpl.lscss..tt.scthF-pLhppKstIE...sphGt.cLpWpc..hs-..+ctsRIh.hhtpsss...lhscspWschhpahscphpph-phatthlpt	....l+pcFWpphhcthttp.......h....t.hpstscpWlsh.ss....Gl.pshphphhh..........spc....pspVpl.Iscss.....ppthF-pLhp.hKstlE...pphut...sl.Wcc....hss.......+csuRIh.hh.t.psls...ht.scssWsphhcahhcphhphcphatth...h...............	0	25	53	62
+13931	PF14089	KbaA		KinB-signalling pathway activation in sporulation	Bateman A, Coggill P	pcc	Jackhmmer:P16449	Family	This family of small proteins is found in the membrane and is necessary for kinase KinB signalling during sporulation. There is a conserved GFF sequence motif. The initiation of sporulation in Bacillus subtilis is dependent on the phosphorylation of the Spo0A transcription factor mediated by the phospho-relay and by two major kinases, KinA and KinB.	27.00	27.00	102.00	101.70	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.26	0.71	-4.73	22	164	2011-05-09 13:52:14	2011-05-09 14:52:14	1	1	164	0	30	125	0	176.80	61	88.75	CHANGED	GulsssIlGhllcaspa..hhhsh-hspllusllahlGlGhh.aSlISQMGFFAYLTlHRFGLuIFRShpLWNtVQllLIhFllFDLlYhRahsFuppspuhhtYlhlslllLlhullVAalKsKpT.NKsAFlPALFFMlVlTslEWhPALpls-pp...aLahhlhPLLsCNAaQLLhLH+lp	................................GGloTsIlGFlLcW-c.YsphFtsF.-stEIluV..FWlhGVGFIFSVISQMGFFAYLTlHRFGLGhFRSuS.LWNhVQLFhIAFVLFDhVYLR.lhh...AsucsSlus.ILlAshLhhFGsIVAYlKoKpT.NKKAFVPALFFMVVVTlLEWVPALRINDsD...WLYLMlIPLLlCNAYQLLlLHRL.l......	0	10	21	24
+13932	PF14090	HTH_39		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:C7PBH6	Domain	This helix-turn-helix domain is often found in phage proteins and is likely to be DNA-binding.	21.30	21.30	21.30	21.50	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.17	0.72	-4.50	51	254	2012-10-04 14:01:12	2011-05-09 14:58:04	1	4	222	0	46	207	80	65.50	28	53.69	CHANGED	sQptclLstLpptss.lTshEAhpphslhc..huuRIp-....LR.ppGa..pIpTph....sppGp.c.+lupY...sLhss	...............ppppllttLppstt..lTsh-uh.pphushc..lu..AcIhc....LR.ppGa....sIhTpp....sphstsptpVstYhL..............................	0	8	24	37
+13933	PF14091	DUF4269		Domain of unknown function (DUF4269)	Bateman A	agb	Jackhmmer:C7PAK4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved KTE sequence motif.	27.00	27.00	28.80	27.30	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.69	0.71	-4.27	29	134	2011-05-09 14:02:34	2011-05-09 15:02:34	1	3	131	0	33	105	1	145.80	57	81.68	CHANGED	acslpchplhctLtsa..sPlLsGTlPlsIDlssSDLDIlCpsp......D.hptFpptlpshauphps.FphcptpI.psh.sllssFphpsathElFuQshPsppQtuYRHMhlEp+LLphttssh+pclhpLK.cpGlKTEPAFuchLul.s....G.DPYtsLLph	........................Y-VLscLsIMEcLAlY..sPVLsGTIPIcIDs.pSDLDIlhEVp......N...aDsFEQch+SLYGoa.cG.FpIK+.KcI.+ssESIp...........VNFcaEGF-FELFAQP+PV+sQNAYRHMlVEHhLLhp+.P+lREEIl+LK.EpGLKTEPAFAQlLsI.s.....G.DPYEtLlh.L..	0	16	28	29
+13934	PF14092	DUF4270		Domain of unknown function (DUF4270)	Bateman A	agb	Jackhmmer:C7PAW4	Family	This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 444 and 534 amino acids in length.	27.00	27.00	61.00	60.80	21.00	20.00	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.91	0.70	-5.86	72	233	2011-05-09 14:05:54	2011-05-09 15:05:54	1	2	191	0	63	235	345	458.80	20	93.05	CHANGED	lGtsllss.s.shssphsshshsspohht.....s.......uVhops......shs...hlGphsDs....aGph.pusahsQlshs....ss..sa.ss.sp.........................................lDSlhlhl.Ysu.................................................................................aG.Dohss...h+lslaclsp...l.................sptaYoshss....ps.........thlush...............sassss...................................shssplplpLsps.............aspplh...ppsp............h.hpsspsFh...shh+Glalpsst.......usGshhhls........ssplplaYphpspsstst................s.....hshss.........hphsphpss.ss...lsplht..pp............sYLKussGhhsplsl.......................slppltp.........p............tp.slNsApLshhh.ss......st..................hshshPpplhLhptcpt..............pshhppsth.sst..ssahuhhp.....................ttpsspYsFs.hs.t.lpshltt.....................pt................ts.chshhlhlsltspss...............tt...........hht......stsshLhGspss............................ppl+LplhYoph	................................lGtslhss.s..phss.phss.hs.ssspohht...s.............ulho..ps..............sss......hlGph.sDs....aGph.pusahsQh.pss....ssh.sF.sttst..........................................lDSlplhlhYsu....................................................................................aG...Dohss...h+lslacLsc..sl.....................tpsptaYoshs..s.hps..........phlust................................sassss.t............................t...................shssplclpLscp.............aGpplh........pttp............t.hpssppFh...phh+Glalpsst.......usGslhhls.........ssplplaY+hptp..sssspst..............hs........hshss.................hphNphpss.ss...lpplhstss................psYL+ussGhhsplsl.......................slsplhp...p........................ppsslNsApLplhh.ss........shp.................hshshPpplhlhptcpt......................pshhppsphssst....ssahuhhp......................spsspYsFs.hst.lpshlps................................pt..................ts.chs.hhlhlslphpts..............................t.ht...................sttshLhGssts............................ppl+lplhYop...............................................	0	23	55	63
+13935	PF14093	DUF4271		Domain of unknown function (DUF4271)	Bateman A	agb	Jackhmmer:C7PG02	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 221 and 326 amino acids in length.	24.20	24.20	24.30	27.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.82	0.70	-4.65	53	191	2011-05-09 14:10:02	2011-05-09 15:10:02	1	1	190	0	53	188	97	205.80	23	75.26	CHANGED	alshlllhshhl....lshs+thhhpphp..sFhhhhhppphhhtpsspph.....haphhhhl.sslhhulhh.....ahhhppht.thhhsh............hhhhshh.hshhhhahlhKhllhphluhlFh.cchhptahhphhphhshh.ul.lLhPlsllhsYhs........hshthhhhhhlhlhllshllhlhpthplhhpphht.hahILYlCALEIhPhllL.aphlh	........................lshlLlssFhl..hhhshs+phh.pphp....sFhhht.tpsphhtspssp-h.....tapl.hLhltsslhhulhh.....ahhhpthtsthhtps............hhhlshh.hshhhhahlhKhllhphluhlFhscpt.sp.ahtshhtlhhhhGh..hLaPhsllllYhs........hslphhh.hhhlhlh..lh.spllhhh.+thplahpphhs.hhhILYhCuLEIhPhllL.aphl.....	0	22	47	53
+13936	PF14094	DUF4272		Domain of unknown function (DUF4272)	Bateman A	agb	Jackhmmer:C7PHI5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 221 and 399 amino acids in length.	27.00	27.00	29.30	28.80	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.53	0.70	-5.33	39	169	2011-05-09 14:13:04	2011-05-09 15:13:04	1	2	163	0	51	163	7	198.20	29	67.51	CHANGED	R+t+ohphLppp.Glshh.ppLPsl..sps-sphRstcElspRAlAlhhlshhAps............tpstphhh.phl.cpasl.hphLTspE+pal...sspss...........cpthhphsW+YEuhasLhWALGhl-..pLshPsplC...Dsshshphhtph.ts.hsphhpp..splRshsEILDttDLhYRh...cWAsVcARl..pstsssu.....slstsVVhER+hALsWLls.............ht...sps.........WDcl	.............R+tpshphLppp.Gl.h...tpLP.l..stppsphRstc-lspRslsLhhlh.tAttl.................tpspp.hh..phl.ppasl.hphLTspEpthlt........ssps.c................tpthhphsW...+Y.EuhhsLhWuLGllc..pLshPschC...........Dsthhh.p.hhtph..t.....p.hpphhpp..sphRshpElL-ttDhhaRh...cWAshcAch.....pspsssu...........sls.ulVhER+huLsWLls.............h.stt.........WDpl......................................	0	21	36	43
+13938	PF14096	DUF4274		Domain of unknown function (DUF4274)	Bateman A	agb	Jackhmmer:C7PQU5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length.	27.00	27.00	31.30	34.00	23.40	24.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.52	0.72	-4.18	39	134	2011-05-09 14:22:07	2011-05-09 15:22:07	1	2	114	0	32	115	6	78.00	25	44.42	CHANGED	hsoscplahhstpaN......aD.s...shplhphllppspCDhuTALhlaWhh.......sstha.hp...........ptptsphhp-t.hphlpplhc+hhs	........soscpLahlsssaN......WD.s....uhcl.ptIlcpspCDhuTALhhFahs.......suhha.hp.t.........tt.sssh.p-h.hphlppltc+hh.t....................	0	10	16	22
+13939	PF14097	SpoVAE		Stage V sporulation protein AE1	Bateman A, Coggill P	pcc	Jackhmmer:P40870	Family	Members of this family are all described as putative stage V sporulation protein AE, although this could not be confirmed. Proteins in this family are approximately 190 amino acids in length.	27.00	27.00	28.00	199.60	21.80	19.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.16	0.71	-4.88	23	159	2011-05-09 14:32:09	2011-05-09 15:32:09	1	1	159	0	34	84	0	178.80	67	93.72	CHANGED	+VILVTDGDphA++slEhsA+plGGRCIStSuGNPohLoGpcLVcLIhpsspDPVlVMFDDsGhhGcGsGEpAhcaVssHssI-VLGslAVASsTcts-hs+VDlSIDRpGcls-huVDKpGhs-hc..t+lpGDTV.sLcpL.slPlIVGIGDIGKMstpDchc+GuPITp+AlchILE....RS	...lhVTDGDEYAKRTIEllsK-hGGRCIStSpuNPT+LTGcclVELIhQTPYDPVFVMFDDSGalGEGuGEcALKYVATHcpI-VLGlLAVASNTHphEWsRVDVSVDRsGsLTEYGVDKaGlP-sE..lGRIsGDTlYCLDcL.sVPVIVGlGDIGKMsGsD-a-+GSPIT+KAIpLILERS......	0	16	26	29
+13940	PF14098	SSPI		Small, acid-soluble spore protein I	Bateman A, Coggill P	pcc	Jackhmmer:P94537	Family	This family of proteins is putatively assigned as a small, acid-soluble spore protein 1.  Proteins in this family are approximately 70 amino acids in length. There is a conserved LPGLGV sequence motif.	27.00	27.00	36.30	49.20	19.60	17.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.08	0.72	-4.05	20	184	2011-05-09 14:51:40	2011-05-09 15:51:40	1	1	184	0	35	94	0	64.70	59	90.65	CHANGED	hNLRpAllsNlpssop-pLccTIsDAIpsGEEKhLPGLGVLFEshWcpussppKpphlpsLcpuL	.hNLRsAVlANVoGNoQ-QLp-TIVDAIQSGEEKMLPGLGVLFEVIWcsAsEsEKcEMLcTLEpGL..	0	9	22	26
+13941	PF14099	Polysacc_lyase		Polysaccharide lyase	Eberhardt R	re3	Jackhmmer:Q7UP23	Family	This family includes heparin lyase I, EC:4.2.2.7.\	\	  Heparin lyase I depolymerises heparin by cleaving the glycosidic linkage next to an iduronic acid moiety [1,2]. The structure of heparin lyase I consists of a beta-jelly roll domain with a long, deep substrate-binding groove and an unusual thumb domain containing many basic residues extending from the main body of the enzyme [2]. This family also includes glucuronan lyase, EC:4.2.2.14 [3]. The structure glucuronan lyase is a beta-jelly roll [4].	29.90	29.90	29.90	30.30	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.68	0.70	-4.69	54	240	2011-05-09 14:57:12	2011-05-09 15:57:12	1	21	167	6	118	254	933	233.50	15	63.76	CHANGED	tshshpushpssshsphpp..ttsstps..........................sssshpGp.................hAl+hphp......hsss.st.......................ut.RuEl.....ptsshphusphaYsauh...hlspsas................ss.p..hlsQa+tps....s...................................................tpPshtlhl.......pssphthphtsss...........................ts.tttphhshsslpt..GpWpchslcs+Wuss........psGhhclWh..........sG..phlhppps.ssthss.................pt......ahKhGlYpsshppsss............laaDplth	................................................................................................................t............................................................t....s...................shp...........tss.......................................sp.RsEl...........tt.th..thGpshhYsauh...hlss.s.at................ss..ptthlsQa+sts...........................................................................stPs.htlth.......pssphhhphpsss........................................................tstphshhhshs..s...hst.....upWhchhlphcasst...................psGhhclah..........sG....ptl.hp...tps...tshhss.................spsh..hhKhGlY+ss.ps........................h.........................................	0	41	77	100
+13942	PF14100	PmoA		Methane oxygenase PmoA	Eberhardt R	re3	Jackhmmer:Q7UPP4	Family	This family is a putative methane oxygenase [1]	27.00	27.00	39.80	38.00	21.90	21.00	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.82	0.70	-5.19	65	174	2011-05-09 15:14:35	2011-05-09 16:14:35	1	6	100	0	95	187	116	281.70	25	73.69	CHANGED	sspslsl...thsG.p......lspYhas........ht......ss....+PalHPlpoh.uGsslTch...........pPtDHsHHpGlhhuhscVs....s....hsFWsspshh................tp.Gphtapshpthps....ssstupl...spclsW.hst......sGph.lLpEpRslshpss....st..............shhl-asssLs.....................sssp.slshs...ss............tY.GGhthRsspsh............................ssuplhsutG............tpGps..........shGpp....us.........WlshsGph.......ssp...............tsslshhscPsN.......thP......s.WasR...shuhhusssssth.........ptshsls...sGcslph+YRlllt-Gsh.sssc.lsshhppa	........................s..thsl.thsG.p.lhpYhhts.........hpss.....+PalHPlpTh.uGss.lTch............pPsDH.....hHHhGlhhuhscVs........GhsFWsspshh...................pp.Gphpppshpthts....ststsph...spplsW..hst......sGp....lLpEpRslshpsh....sst..................sahlDhshsLs.....................sssp.slphs.ss............sY.GGhhhRsscph............................ssuplhsutG...................tpucp...........shGpp....us.........WlshsGph.....................sst...............ts.olshhspPsN.......ths......s.WalR....sts.hhusssuhsh.........ptphsls...sGcslph+aclllt-Gth..stsphsthhpt....................................	0	48	79	95
+13943	PF14101	DUF4275		Domain of unknown function (DUF4275)	Eberhardt R	re3	Jackhmmer:Q7UUJ6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.	27.00	27.00	31.60	31.50	20.20	18.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.03	0.71	-4.11	13	119	2011-05-09 15:22:53	2011-05-09 16:22:53	1	1	112	0	16	94	1	132.80	57	95.41	CHANGED	ME....lhchLcp..+slKlpEhspWGshhRKpWEcpFAsHLohcEKcpIhlhsscshs..GYLWHlFSY-p+...sCLcGcEAcpAFcpcpKssCYlFaQasD-slllEcAspLpAsDL.s.......Eh......DlYVVDc-FsWTaVhTHEscahGPYFs	......................ME.hl-hL++..KshKVREhpp.WGsYFRKRWEDpFAN.HlScEEKE-IaLYsDchsC..GYLWHIFSYE+K...KCLEGcEAEpAF+sEsK+-CYIFYQHsD-VLl.lcDAShLph-Dllp.......Essp...ha+uDlYIVDK-FTWTFVKTHEccW.CGPYFs.........	0	6	10	12
+13944	PF14102	Caps_synth_CapC		Capsule biosynthesis CapC	Eberhardt R	re3	Jackhmmer:Q7UXU8	Family	This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production [1].	27.00	27.00	35.60	29.30	24.20	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.53	0.71	-3.99	31	208	2011-05-10 07:29:10	2011-05-10 08:29:10	1	2	193	0	50	120	38	120.40	43	66.61	CHANGED	slGlllSLlasEpsGlssGGllVPGYlALhh.spPhplhlslhhSllTahll.phlu+ahl.......lYGRR+Fshhlllull........lphlhphh..h......................h..phpslGhIlPGLIAsphp+QGlhhTls	...............lGllLSLlFsE+hGlsPuGLVVPGYL.ALhh.spPlhllsllllSlLTYhIV.pslS+ahI.......LYGRRKFAAhllsGhl........L+hlhchl..h...............l.ssFths..-hpuIGlIlPGLIANoI.p+QGlshTl.h...........	0	18	37	47
+13945	PF14103	DUF4276		Domain of unknown function (DUF4276)	Eberhardt R	re3	Jackhmmer:Q7UYP7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 224 amino acids in length. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	27.40	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.29	0.71	-4.45	56	288	2011-05-10 07:40:08	2011-05-10 08:40:08	1	2	220	0	123	324	17	189.50	16	90.84	CHANGED	llEtsotpphLcslL.+hh........thphphhshthc.slppphscph..+sapphh..........stllllhDpDs.ssstphppp......p.htp.t..tpt..............s+lsspEhEuWaLuD.hpAl..pphhsph.sphsh.......tt.pKhpsP-sl.susppt................tspYp......Ksptuptlustl......shspsp.S.SFpp.....hlpulpph	....................................................................................................hhEs.o.ppthlpt.ll..hh..........................th.h.hh.h.ht.pht.tt....hs..t.th...............pthpp.h.t.....................shlhshhD.....h.s...hss....st...ttph................htt...........t...h.............s...t.......phhshlt....hcEhEuWhhuD.h.p.u.l..tphhsp......tphth...................t.htpht.sP-plpsu..sppt......................thhstYp.............Ksh..tu...tlstpl.....s.phhppp....sspFptalptlt...................................................................................................	0	44	88	113
+13946	PF14104	DUF4277		Domain of unknown function (DUF4277)	Eberhardt R	re3	Jackhmmer:A8ZKM0	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	25.40	25.40	25.40	25.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.27	0.71	-3.89	23	342	2011-05-10 07:59:00	2011-05-10 08:59:00	1	2	80	0	129	362	22	108.60	39	26.46	CHANGED	Mp.........p.pl...+sLDHLGlVAGlhDElslschIDchLspcppc+.lSpGpslKAMILNGLGFsu+sLYLFPpFFpsKslE+LlGpGlpA-aLNDDtLGRsLDcLYchGsoplFtplAlp	.........................................................thpl.pslDHLGlVAullDclGlsclIsph.lsh-..s.p.c.p.losGpsVKAlllNGLGFss..psLYlaspFFpshshE+LlGps..lpPcaLNDDtlGRshDcLYchu.lsplF..lsh.p.............	0	43	106	116
+13947	PF14105	DUF4278		Domain of unknown function (DUF4278)	Eberhardt R	re3	Jackhmmer:A8ZNS8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 58 and 136 amino acids in length. There is a single completely conserved residue R that may be functionally important.	25.30	25.30	25.40	25.30	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.58	0.72	-4.02	53	145	2011-05-10 08:06:48	2011-05-10 09:06:48	1	2	71	0	65	166	197	56.30	30	62.60	CHANGED	M....cL.....sYRGlsY-.hsssslp...............sspsp............hsupYRGhsa.......hpphsh.psp...hsLp.YRGVsY	......................M..pLsYRGlsYs..s.sssp...............htpsp............lphpYRGhsY......phpphppht.s...t.hp.Lp.YRGlsY..................................................	0	5	47	58
+13948	PF14106	DUF4279		Domain of unknown function (DUF4279)	Eberhardt R	re3	Jackhmmer:B0C1A4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	25.00	25.00	25.60	25.40	24.70	23.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.23	0.71	-4.22	48	184	2011-05-10 08:13:26	2011-05-10 09:13:26	1	1	166	0	42	156	3	116.00	23	83.66	CHANGED	lhu-shs......s.-plTphlulpPopsht+Gshhpss...p......hhtphssWtlsoptttpts...lp..cplcpLlppLp....sttstlppltpphsh....p......thhshh.shssspsss....................lsschlphlsslGsplsl	.............................lhG-.hss.-tlTphLslpPTcshtKGchhtppp...........hhpppssWpls...othppshc.....lp..splphllcpLp......scpptlpclppcasl...p.........hlhhlhhp.hpssp.sPs....................lspchlphhuslsu-lch.........................................................	0	13	31	35
+13949	PF14107	DUF4280		Domain of unknown function (DUF4280)	Eberhardt R	re3	Jackhmmer:B0C1L7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 129 and 456 amino acids in length. There is a single completely conserved residue C that may be functionally important.	25.00	25.00	25.30	25.50	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.90	0.72	-3.74	69	265	2011-05-10 08:22:45	2011-05-10 09:22:45	1	18	148	0	84	252	15	112.10	27	38.96	CHANGED	VssGAhlpC.shGsss...utLpVhs....ps.plhspu.....p.hAohtDhhsh.....hNlhsFG.........hCpsh..sssss..................ChPs......ss.Wt...st.sslhl...........suts.sLpssSphhCsa.G..Gh..Iplhss......GQt	.................................lstGAhlpC.shGsss...shLtlhs.....tp.ts.hhss.....................tshushtDphsh.....hNI..sFG...............................hCps...ssssht...............................................ChPs...hs.Wh..sst.ssshl...........ssts.sLspsSphhCsh..G...Gh...IphhssGQ...................	0	24	63	73
+13950	PF14108	DUF4281		Domain of unknown function (DUF4281)	Eberhardt R	re3	Jackhmmer:B0CBE6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 147 and 232 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	27.00	27.00	32.80	32.40	23.50	22.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.70	0.71	-4.04	70	170	2011-05-10 08:58:51	2011-05-10 09:58:51	1	2	128	0	92	165	946	126.70	30	64.30	CHANGED	stlFslushhslPhWhLhl........hhP...php.......hTp.plhpohh..shlhLu....hlYhhlhhsuhss...ssssh...........................hssL.s..ultplF...............usptsshsuWl.HaLshDLFVGpWlhh-upcpu.l......hhh.sLlLshhhGP.lG.LLsa	......................t..lFshushhslPhWhLMl........hhP...php.......................hTc..clhpShh..shlsLu....hlYshLlhhuhsstshthh..........................hssLs.ulsphF...............usptssssuWl.HhLshDLFlGRWlah-utc..ps......l...........hshhsLhLshhhGP.lGLLsa........................	0	45	80	89
+13951	PF14109	GldH_lipo		GldH lipoprotein	Bateman A	agb	Jackhmmer:C7PII4	Family	Members of this protein family are predicted lipoproteins, exclusive to the Bacteroidetes phylum. Proteins in this family are typically between 155 and 167 amino acids in length. Members include GldH, a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii [1]. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Not all Bacteroidetes with members of this protein family may have gliding motility.	27.00	27.00	27.30	27.60	26.00	22.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.38	0.71	-3.93	60	194	2011-05-10 08:59:56	2011-05-10 09:59:56	1	2	190	0	54	193	141	132.50	28	81.38	CHANGED	psplac.papsls..s..uWp+scslpFpl.shtDss.s.YslhlslRssssYPapNLaLllphphs..p.uph.....hsDTlphpluc.ss....GphhG.pGhus.lhppph.h....pshpFs.csGpYplplppsMRcs.......sLpGIs-VGl+l	......t.ptlYc.pYpsls..s...uWp+s-s..lpF.sl..shp..D.sh.ssYplhlslRssssYPY..pNLaLhlp.hphs....ssph......hsDTlphpLs-..ps....GphhG.pGhus.lhppph.h....psh.ph..csGsYplplppsM+cp........LpGIsDlGl+l....	0	23	48	54
+13952	PF14110	DUF4282		Domain of unknown function (DUF4282)	Eberhardt R	re3	Jackhmmer:B0CFB0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 93 and 155 amino acids in length. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	28.20	27.80	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.99	0.72	-3.79	54	193	2011-05-10 09:26:58	2011-05-10 10:26:58	1	3	179	0	82	176	29	83.40	25	68.64	CHANGED	h.hsFccalTspllphlYhlulllhslhslssl.....huuh..............................s.hhuhhtllh.uhls...hlhtllhsRlhhEhhlshh+ls-slppltcpt	...........hpF-palTPpllphlYhlsllhlslhuls..sh........hsuh.......................................hhhhl...h.uhlh....hllshlhsRlhhEhllslF+ls-sLpcItcp.s.....	0	26	54	70
+13953	PF14111	DUF4283		Domain of unknown function (DUF4283)	Coggill P	pcc	Jackhmmer:A0MDU5	Domain	This domain family is found in plants, and is approximately 100 amino acids in length. Considering the very diverse range of other domains it is associated with it is possible that this domain is a binding/guiding region.  There are two highly conserved tryptophan residues.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.61	0.71	-5.13	121	920	2011-05-10 09:46:33	2011-05-10 10:46:33	1	139	22	0	264	872	0	122.60	17	16.68	CHANGED	lplsccth.......hltp....sLl....G+a.......hs.p.......lps.ltphhtptWtLpu...plpltpl..s...p...s......hhlhcFcptt-hc+VLppGshthps.hhlhLc+W.s...spssshp.pthpph.lWVRlhsLPlphasp.phhcplGsthGt.hlplD.pstphpphp..as.....Rlh.Vc	....................................................................h.......................................................h....h.t....a.t.....t...ththh.h...t...t......s......hhhhpFpt.t-h.pplht......t...us..h.h.h..p.s.....hhl..hlp..pW.s.........t.s.....t.....t.ph.h..hWlcl..h..slP.hthhst.phhpt.lu.pthGt.hhtlD.t.s..t....h....hp....hh+lhl........................................	0	25	157	230
+13954	PF14112	DUF4284		Domain of unknown function (DUF4284)	Bateman A	agb	Jackhmmer:C7PJ13	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 124 and 142 amino acids in length.	27.00	27.00	29.30	28.00	25.40	26.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.93	0.71	-3.64	22	158	2011-05-10 12:25:39	2011-05-10 13:25:39	1	2	101	0	24	145	0	117.30	28	81.12	CHANGED	hVolWlG.sFpopp-hppYh-.........cY....-.E-ucplsSpFtp-hsltah..DcDhlEtshhsps.t............slppLLpshSYspphlpph.phh...ph..pphNslIhlYshc..Ystphcpsp............lpalGshpYc	.................VSlWlG.sh.p.oppplcpYh-l...................pY......c.--G-pl.supFhpDFsls.hh..D-D..hlEhphhpps.ps............slptLLpshS.Y.cp.pl.lsphhphh...th..pphNulIhlYsap..Ysppsppspt............hpalGshtY.............................	0	6	13	19
+13955	PF14113	DUF4285		Domain of unknown function (DUF4285)	Bateman A	agb	Jackhmmer:C7PJQ8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 157 and 206 amino acids in length.	27.00	27.00	27.70	27.60	25.90	25.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.93	0.71	-4.10	48	220	2011-05-10 12:39:33	2011-05-10 13:39:33	1	3	185	0	60	159	4	122.90	37	69.00	CHANGED	ssapNsCAl.RhShuLppsG....hshpshs.............hthhh..ss........+hhhh..RspchtsaLp..p...s.......................ssshtsplpu...............+pGIIhF...hthWspu........uG...HlsLW...NGsphs......sps..................................................shtpspplhFW	...........................................................h..apNsCsIRMSYsLNto.G....hslspto................htpluGsDs........KhYha..RVs-hhcaLp+p.......hs...........+P-hIs....................sssppuchhG...............KKGIIlh.pspGWosA........pG...HlTLW...NGohso..DpCah................................................................................	0	19	28	44
+13956	PF14114	DUF4286		Domain of unknown function (DUF4286)	Bateman A	agb	Jackhmmer:C7PK46	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 100 and 112 amino acids in length.	22.80	22.80	22.80	22.90	22.60	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.11	0.72	-3.72	46	171	2011-05-10 12:48:32	2011-05-10 13:48:32	1	2	166	0	61	159	102	97.20	30	86.20	CHANGED	IYNlThpl.-csltccWlpWh.pcpHIP-llsost...Fppuplh+llscp-ts.........GpoYolQYpscspssLppYhpcpuscLcp-shppFusKhluFc....Th.LEhl	........IYNsThpl.-cslccpaltWh.pcpaIP-lhpsGt...hpps+..ls+lLs..cc-pt.........GpsYSlQapscspssLpcahpc....puscLpp-hhchFt..c.KhluFt....Tl.hEll.................................	0	31	56	61
+13957	PF14115	YuzL		YuzL-like protein	Eberhardt R	re3	Jackhmmer:C0H3R0	Family	The YuzL-like protein family includes the B. subtilis YuzL protein Swiss:C0H3R0 which is functionally uncharacterised. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	33.40	33.30	23.00	17.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-7.92	0.72	-3.68	7	211	2011-05-10 13:53:45	2011-05-10 14:53:45	1	1	121	0	23	67	0	42.10	53	90.24	CHANGED	sKhKKsPSKsGlSAssV+Gp.GsT.pcsGuh+psStppphKKc	..KlKKsPS+uGlSAssVcGp.GsT.s+ts.u.st+.sSsNpphK+..	0	1	11	14
+13958	PF14116	YyzF		YyzF-like protein	Eberhardt R	re3	Jackhmmer:C0H3T9	Family	The YyzF-like protein family includes the B. subtilis YyzF protein Swiss:C0H3T9 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	30.60	30.20	21.20	17.50	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.37	0.72	-4.01	25	164	2011-05-10 13:59:09	2011-05-10 14:59:09	1	1	164	0	35	95	1	48.20	47	83.06	CHANGED	sCcEHlElAlDpaVD-hEpsPslpclpcsp......sppCcaC.cptApYlVs	.sChEHlElAlDhhVDEpEluPsIppl-soc....p.ppsC.-aC.pspAsYlVs..	0	11	23	28
+13959	PF14117	DUF4287		Domain of unknown function (DUF4287)	Bateman A	agb	Jackhmmer:C7PKG7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 70 and 180 amino acids in length.	27.00	27.00	27.90	27.00	24.20	23.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.90	0.72	-4.28	59	198	2011-05-10 14:04:37	2011-05-10 15:04:37	1	2	162	0	95	200	86	60.60	38	62.24	CHANGED	uhpoYlss.Icc+TG+slscWhpll...cpp.........sssKat-hVsWLKsEHGLGHGHAsAlVthhctp	...........u.toYhss.IEcphG+sls-Whpllcpp.........shs+ahElVuWLKsEH.GLG..HGHAsAlVshhht.t............	0	33	71	88
+13960	PF14118	YfzA		YfzA-like protein	Eberhardt R	re3	Jackhmmer:C0H3X6	Family	The YfzA-like protein family includes the B. subtilis YfzA protein Swiss:C0H3X6 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	27.00	27.00	32.60	32.50	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.23	0.72	-3.88	4	111	2011-05-10 14:05:57	2011-05-10 15:05:57	1	1	78	0	6	58	0	91.00	59	97.31	CHANGED	MssK...tpPl..hKRsWhpolssFllsQLlFIIhEhTuWhP..sF+-.Gshhs+lVsSpFFTcWFu.YcsPaFNllTlFhuIhhll.slhGAhKDlhspt...N	..........hh....K...tpPl..hhRsWh+hLGsFhlhQLlFIlsE.lTuWsP..NF+..GpFhsR....llN.S..pFFTEWFoPYKhPpFNVhTAFaAIhLl..uLluAhKDhpoRKp.........	0	2	5	5
+13961	PF14119	DUF4288		Domain of unknown function (DUF4288)	Bateman A	agb	Jackhmmer:C7PM87	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	27.00	27.00	27.60	27.00	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.91	0.72	-3.86	22	131	2011-05-10 14:09:39	2011-05-10 15:09:39	1	2	128	0	20	109	2	90.90	45	74.05	CHANGED	aYlsphlhchh..........t.psstpppshhcEphlLlcAcop....-cAac+upc.hut.ppcpsapN..p.sptlpachhsls-lh.l.h-pl-c.G....sElau	...............hYuVKLLFEol..........hspch-cs+coLFEES.IILVKAsSh....EEAHtLuEp.lAh.puEc.TYcN...hh..sEQlTWoFRKl...LcVFEL..spssFEo.G....pELYu..	0	13	19	19
+13962	PF14120	YhzD		YhzD-like protein	Eberhardt R	re3	Jackhmmer:C0H3Y1	Family	The YhzD-like protein family includes the B. subtilis YhzD protein Swiss:C0H3Y1 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved GKL sequence motif.	27.00	27.00	31.30	73.80	23.10	17.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.89	0.72	-4.07	15	141	2011-05-10 14:12:53	2011-05-10 15:12:53	1	1	141	0	23	80	0	61.00	67	97.73	CHANGED	Mp.sYhLTVF-psGEpLL-EpFEAusD-EAKchGcppLcE+shpc+THRhssu.GKLlLFHR	MG.lYVLTVFEKDGoKhLDESFEAATEcEAKsKGEuILpEKGLaEKTHRCTSoAGKLVLFpR.	0	6	15	18
+13963	PF14121	DUF4289		Domain of unknown function (DUF4289)	Bateman A	agb	Jackhmmer:C7PM99	Family	This family of membrane bet-barrel proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. Swiss:Q2S343 is identified by Gene3D as a membrane bound beta-barrel.	27.00	27.00	39.20	27.70	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	614	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-12.85	0.70	-6.10	62	213	2012-10-03 17:14:37	2011-05-10 15:18:18	1	3	201	0	58	222	301	617.50	27	91.63	CHANGED	.slpsapl.s.hht-pphs..sssThpptapp.shhpt.phchhshuNlGpshpshhat.c...p.htshhhhcshchhhhps...............cclpaasshoPhTpLhYpssspp...tpphcuhauhNhsc+.......hshuhpachlhupGhYps........ptsuphN.hphhsuYhuc..RYphpstasspch.pspENGGl.ss-shhptspph.....................ppp......aps.splsspL..pps...pNp.cspchalsHcYplshpp.hsth......................................................................................................................shhHohpa-spphhapps.......t.h..psht..................h.ssshpDpTphhplpNphuls......asph.hh..utlpsahstchhp.Y.....thssh.......................hh.pphpppplslGGpl.t+p.uphhchpupu...c..htl.stshuphplpuphshsh...t-sh.pltushhh.pspsPsFhh.phapSpa..a.WpN......shsp.ppppltup..lshp+htsplpsshsp.........lcNYsYF.......................sspstspQpussIsl.LphplppcFp.hGhaph-NplhaQpsos..psl.........LslPplsshsslYhphpl...hp.KsLhlphGhsh+YFTp..YhAssYsPslupFhlQs.........phclGsaPllcsahNh+l+psRlFlthpHlNsuh.ss........sYFhsPpYPhpshhl.+FGlsWNFFs	...............................................................tlh.apl.p.hhsspphh...ssDThtpta.pp.shhpt.php..hs.huNlGsPh.shha.p+pp.......t.hhhh.psh...shhhhps...............schpahso...oPhTpLtYppuusp...ppphcuhauhNhs+c.......lshGhsachlhucGh...Yps..........ptouphN.hphauoYhuc..+Yp..hpshhsspph.cssENGGI.ss-phlspspph.................ppp...........ap.s..splsshL.sps..............tNp.cspphalspcYsLuhp+ph...s.t....tsth.........................................................................................................uhhHohph-pppppapst.....tpspsaatpshh.....................ssshpDpTphh..s.lpNphuls.........sFsph..sp....usLpuahsachhp.Y..ph.sh..............................h.pphsppplhlGGpl.sKptGphhchpspu..E...hsl....spshGphplcuphshsh.....t-ss.pltApu.h...psptPs....Fhh.ppapSpa.....ahW.cN......shspphpspltup.....ls..hp+h...tspLpsshps.........lcNYsYF..............................sppstspQpu.usIpl.lphplppcF...+.hGhap..h-Nplh..aQpoos..psl.....................LslPplsshsslYhphpl..h..KsLplphGs-s+YF.Tc..YhAs..sYsPslsp...FhlQs............phcl.Gs.Y...PllssasNh+l++.sRh.FlhhpHlNsuhhss.........sYFhsPcYPhssth.l.+hGlsWNFas..............................................	0	25	52	58
+13964	PF14122	YokU		YokU-like protein	Eberhardt R	re3	Jackhmmer:C0H434	Family	The YokU-like protein family includes the B. subtilis YokU protein Swiss:C0H434 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two conserved CXXC sequence motifs.	27.00	27.00	28.10	28.00	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.05	0.72	-4.26	10	136	2011-05-10 14:25:58	2011-05-10 15:25:58	1	1	128	0	14	62	0	83.70	68	95.75	CHANGED	sCcWCsppcAssspsoVYWELPDGT+AIEIs-TPuIsCSuCGMsYQ--sllcEIEDQLlLIDoKKLPcslTYcpLMsp-RlLKRNYF	........................MWCDSTEAKESLNTVYWELPDGTKAIEIQ-TPCISCSSCGMDYQuDpTVKEIEDQLFLIYTKDLPKQLTYEELMuRPRLLKRNYF...................	0	2	8	10
+13965	PF14123	DUF4290		Domain of unknown function (DUF4290)	Bateman A	agb	Jackhmmer:C7PMG8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 200 and 221 amino acids in length. There are two conserved sequence motifs: EYGR and KLWD.	27.00	27.00	50.20	50.10	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.08	0.71	-5.08	48	201	2011-05-10 14:29:21	2011-05-10 15:29:21	1	1	197	0	55	186	178	174.90	47	82.69	CHANGED	L-YNTpRp+LllPEYGRplQpMV-aslslcD+-ERs+sAcsIIslM.GphpPcL.RDssDapHKLWDpLhIMSsFcLDlDsPashsscEpLtp.+P-.lsYPpsph+aRaYGpsIpphI-pAhphEcG-c+-uLlhsIANpMK+salsWNK-oV-DchIhpcLt-LScG+lpLstss.cL	......h-YNTp+c+LhlPEYGRpIQpMVDaslolpD+cERp+sApoIIslM.Gsh.PHL.RD.VsDFpH.KLWDHLtIMSsFcLDlDhPY-l.spc.-s.L.ts.+P-.lsYPpsph+YRHYG+slcphIc+Ahchp-G-c+csLlthIANaMKKsalsWN.K-o.V-DcpIhcDLt-LSsGclpLstpt..h.......................	0	24	49	55
+13966	PF14124	DUF4291		Domain of unknown function (DUF4291)	Bateman A	agb	Jackhmmer:C7PN25	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 190 and 214 amino acids in length. There are two conserved sequence motifs: VYQAY and RMTW.	27.00	27.00	49.30	38.30	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.15	0.71	-4.66	57	206	2011-05-10 14:31:31	2011-05-10 15:31:31	1	4	187	0	91	186	3	173.00	44	83.25	CHANGED	+pIRA..ta.sscTIsVYQAYsspIAcsAlpst+Fs.sP.FphsRMTWIKPSFLWMMYRuGWupK.tsQERlLAlcIpRcGF.-hhLppusLSph..............................tsthh.sptpWppplppus......................VRlQWDPERslphpsL....saRSIQlGLsschlc.cYsc-WIluIpDlTshs+clcphlpsu.....phcpAttLLPt..EcsY	...................pIRA..pa.sppTITVYQAYsssIAssAlcsG+Fs.us.Fph..sRMTW.IKPSFLWMMYRuGWutK.tsQE+lLAlcIpRpuF.-hhLppAsLSph.................................................ps.plasp.tstWcpth...ppus......................VRVQWDPERsl.php..L....taRSlQlGlssphlp.pas--.WI..VuIpDlTshs+ch+pllpsG.....chppAtthlP.Ec.Y..................	0	35	61	79
+13967	PF14125	DUF4292		Domain of unknown function (DUF4292)	Bateman A	agb	Jackhmmer	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.	27.00	27.00	27.20	27.30	26.40	25.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.09	0.70	-4.91	73	228	2011-05-10 14:33:12	2011-05-10 15:33:12	1	1	225	0	80	221	184	198.30	21	75.77	CHANGED	ssphcslsuchplslp..tpppp.sssssl+hc+-ctIhlSs..shlG.hpVu+hhlTP-plhhhD+lpppYhpu..saspLp....chlshs.lsFp...pLpslLlGp..hhhshppphp......hphs......sp.th.lp.pp..........sthphthhhsspshplpphpltptss...ppplphpYtsapph.....stthhPtplplth.p......ttppsplslpasc...hsh.spshphsaslPspYcpl	.................................................................................................................t...hpslsu+hplslp..sppppholsssl+hc+cchlhlol..shlt.hEluRh.lTPDplhhhD+hs+.pYhcu.......saspLp....plhshs.lsFp...pLQsLlhsp.......hhhstppphp.......................hp.t........tt.h.lp.pp.....................tthth.hhhsstphhlt..p.plt..t.st...t.tlphpYtsap.h.....stt.hPtphplth.p.......tpphplplphpp...hph...spsh...p...h.hphsptap...................................	0	33	61	76
+13968	PF14126	DUF4293		Domain of unknown function (DUF4293)	Bateman A	agb	Jackhmmer:C7PP09	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 154 amino acids in length.	27.00	27.00	27.10	29.00	25.30	24.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.91	0.71	-4.28	71	211	2011-05-10 14:35:41	2011-05-10 15:35:41	1	2	209	0	68	197	86	143.70	32	97.01	CHANGED	IQRIQTlYLLlssl.hssshh.hhPlhphssssthhh..t.h..h............................hhhslhhlsullulhuIFhaKpRtLQhpLsh...lshlLhl...hhhulhshhhhshtsph........hshphthuhhlPllullhhhLAt+uIp+DEcLV+usDRL	............................IQRIQTlYLLlssl.lhhshh..hhPlhphhss..shhh.....hthhsh.h....t.....................slhslhhlssllulhoIFhaKpRh........lQhplsh....hshlLhl....shhshhs.hhhhslpsph..........hshphuhuhhLPllullLhhLAh+uIt+DEtLV+usDRL......	0	25	53	65
+13969	PF14127	DUF4294		Domain of unknown function (DUF4294)	Bateman A	agb	Jackhmmer:C7PPB4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 192 and 226 amino acids in length.	27.00	27.00	83.40	82.90	23.60	23.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.85	0.71	-4.63	44	181	2011-05-10 14:42:30	2011-05-10 15:42:30	1	1	178	0	44	172	171	154.90	44	73.32	CHANGED	GDoIs....hlpLspVhlhsph+.Fcsc....c-cppYhhLhRcV+KVhPhAKhsscplh-htchLpolss++s+c+ahKhlcKhlcccaosclKKLThoQGplLIKLlpRQTupToY-LlKshhuGa+AhaYpshAthFshSLKccYcP..stEDhLlEcllhps	.......................tDoI...hlpL.spValas.hc.F+..sc....c-+pcYh+LlcsVKKVhPhAK.ssctllEh.caLpTlPsc+t+c+ahKpVEKtlccpYoschKKLohoQGKlLIKLIcRpospooY-LlKuahGsa+AsaYQshAtlFGsSLKccYDP..ps-DtLhEcllhh.s........	0	15	38	44
+13970	PF14128	DUF4295		Domain of unknown function (DUF4295)	Bateman A	agb	Jackhmmer:C7PPC2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (K and Y) that may be functionally important.	27.00	27.00	27.20	32.00	26.00	26.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.29	0.72	-4.34	27	189	2011-05-10 14:44:08	2011-05-10 15:44:08	1	1	188	0	52	149	49	47.70	61	93.33	CHANGED	AKKs.....VATLpput..uKphoKlIKhVKSsKTGAYsFcEchlss-pVp-al	..............AKKs.....VATL+pGp...G+saTKVIKMVKSPKTGAYsFcEpMVsNEpVpDFh.......	0	24	47	52
+13971	PF14129	DUF4296		Domain of unknown function (DUF4296)	Bateman A	agb	Jackhmmer:C7PRC6	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length.	27.00	27.00	28.00	29.60	26.30	26.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.82	0.72	-3.83	55	193	2011-05-10 14:45:37	2011-05-10 15:45:37	1	1	192	0	54	193	131	86.70	28	35.94	CHANGED	PcslIscccMpslLaDhaLscuhtt.........tsppptstpthshpphlacKaslssspFspShsYYspp.scphpcIYcclpcRLppcppshsp	....................PpslIspscMcslLYDhHlupuhtt.........stshspshpphthh.ptla+KaslopspF-sShhaYscp.s-hhpcIYccVpcRLcscppth..t........	0	23	48	54
+13972	PF14130	DUF4297		Domain of unknown function (DUF4297)	Bateman A	agb	Jackhmmer:C7PUH4	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is typically between 207 and 221 amino acids in length.	27.00	27.00	27.10	27.10	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.55	0.70	-4.39	34	146	2011-05-10 14:49:40	2011-05-10 15:49:40	1	6	139	0	34	124	9	198.00	20	46.26	CHANGED	.pEpuGstutptFcaQhpaAlhpllchhpsps.shtlhhEh+-Dlslhps.t.t.sph..-ahQVKTpcss...pWohssLsch...............................pppp.............Shlu+Lhpp..pppas.stssplthVostsh...shslcshphshppt.......splpsphtpplp...pp...lpsphshsp..h.hstlhhl..hssls.Lcshppplhuplsphl..chhsp.stp.spslhctlhcplcc+us	.....................................p-puGstuhptFpaQhphAlhphhphh..p......p..ps..satlhhE...........hc...........-.Dlsltps......sph......sFhQVKspp.......pt....saoh..ps...lspp.......................................pptpt..............Shlu+Lhpp......ptpht...ptsp......c..lthlospsh........shs.cp..phphtsh.........tplppp.tpplp...pp.....................ltsphs.t...h....phlhhh....hssls..lpsh.tp..hhuphsp.h..phh.p...p.spslhp.lhpphp.+u...........................................................................................................................................................	0	13	24	29
+13973	PF14131	DUF4298		Domain of unknown function (DUF4298)	Bateman A	agb	Jackhmmer:C2M2S9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 94 and 105 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.	27.00	27.00	27.20	29.30	26.80	26.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.04	0.72	-4.11	25	275	2011-05-10 14:52:29	2011-05-10 15:52:29	1	1	267	0	31	183	1	85.70	29	84.60	CHANGED	+IpchpctaschpchlscLpcsl-papcshpchppLpsYY.oppWhcDhps.pps...phss.chptuVLSEDulashhu-phpLAhphLclus	..............+IpcMpphhpchsphLspLpcslpphpct..pphtpLcsaY.op-ahcshct.pps...........phss.phstuVLSEDulashhs-pppLAhphLcl.......	0	10	18	27
+13974	PF14132	DUF4299		Domain of unknown function (DUF4299)	Bateman A	agb	Jackhmmer:C2M3B8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	27.00	27.00	28.80	28.70	25.70	25.20	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.90	0.70	-5.28	20	348	2011-05-10 14:56:01	2011-05-10 15:56:01	1	1	303	0	17	200	0	267.10	50	97.31	CHANGED	SloFaIKNK+p.hh.uhpclhoscclLsLsct..Lppauh-tsppphshpchhtt.ltp.t....sllhGspspSuRGFELuYsccppsY.sVRlhTPSopsDWplALpalpsLupph.sscIhsE.pGcpaoscsIppFDYcsDIhhGlcsl.tplpscpttsh....haGlpRPlshscchl-cIhsupss..lcpFuchlcch..QaLDAY.A+QpFacspsssc..IhGhYsLopslcTILPac..P...V-hpshphlpsc-luhWplsllshsu-csc..ptYphluplcYccFlcpLPc-KYcalDAsYIhVcsLo+-Elpcl	...........................................t.hTFaIsNKpS.lL.GpQclLsAKSILuLlDG...LESHSYDsshLRQsLN.RLp............hIcCulsGpSphhF+VSYsDup.KuY.pVclPDhhT+sDWpIlhsFLcALhuhh.Go-I...........EGL-sF..DFEAaFpuuIpsaLuD.sA+h.shCp......GIhsPlaFS+EpLcuFLcuDu...LApFEspVRsl..QpoDA..YFA+spFYpDu-.GK..VaGlYaLAQGV+TVLP+E..P....aVPss..YlEQLs-+EVp...W-IcLVpIoGDusK.PEsYEuIARLDYscFLEsLP.saY+pLDA.sQIcVQPIhsp-hcsL.......	0	4	6	11
+13975	PF14133	DUF4300		Domain of unknown function (DUF4300)	Bateman A	agb	Jackhmmer:C2M4P8	Family	This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 281 and 303 amino acids in length. There are two conserved sequence motifs: NCR and PYQ.	27.00	27.00	54.40	54.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.64	0.70	-5.11	36	333	2011-05-10 16:08:49	2011-05-10 17:08:49	1	1	320	0	24	172	0	241.20	60	83.36	CHANGED	hsYSNLssppSpcEVpshL......sAslsppslcpFhphVs-YNs.sl.....ppstlpssFssh...tps-YDh.t..IpchWpc+pss.Fh.GsNCRIouFsLhKshIpsssstp.......ssph....LFhDt-uIcss..............plhspp-cpcFpsLFopl.Tc.....sTpDlc.hHtpphpctaKphtlpF....tss+hpllSVhlHsp...-sshLFlGHsGVLlsscsG.aLFlEKluFppPYQAlKFss+p-lpc.YLhs+Ycs..htspsp.A+PFIM-NDchl	...................................u.SYoNLNspsSsEEVKSLL......SAHLDssSVDuFFNLVNDYNs.lV.....GSTGLoGDFToF...T+TEYD.VEK..IScLWspKKGD.FV.GTNCRINSYsLLKNSlTIPKlEK.........sDpL..LFlDNDAIDKG..............KlFDupDKE-FDILFSR.VPTE.....ATT.D.VK.VHA-KMEsaFSQ..FpF.....NEKARMLSVVLHD...NLDG-aLFVGHVGVLVPsDDG.aLFVEKLTFEEPYQAIKFASKEDCYK.YLuTKYsD..YTGEGL.AKPFIMDNDKWV.............	0	8	14	19
+13976	PF14134	DUF4301		Domain of unknown function (DUF4301)	Bateman A	agb	Jackhmmer:C2M610	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 505 and 516 amino acids in length.	27.00	27.00	84.20	83.60	21.10	18.40	hmmbuild  -o /dev/null HMM SEED	513	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.69	0.70	-5.95	43	177	2011-05-10 16:11:31	2011-05-10 17:11:31	1	2	172	0	47	182	62	495.50	53	98.03	CHANGED	hoppDlpQlcp.......+Glo.cplppQlchFccGhPhlpL.puAolscGIhtlsscEpcphlsha-p..tppstcllKFVPASGAAoRMFKsLapFL.............su.hscppssthppFFsslccFsFYccL.ppslpspt.slssLhsstchtt.llctLLstcGLNYGshPKGLL.FHpYs.-ts.pTP.....hEEHLsEuAhYAsss.upsclHFTVSp-HhctFcpplschtsphEpchsspacloFShQ+sSTDTlAVsh-.NpPFRsc-GpLLFRPGGHGALI-NLN-lDADllFIKNIDNVV....s-ph+pcTlpYKKlLAGlLlplQc+sFpYLchL-ps.phscpplpElhpFlpccLshph....s.phpphsppphhpaLpp+LNRPlRVCGMVKNpGEPGGGPFWltstDGslSLQIlESuQIDhssscptphhppuTHFNPVDLVCul+sY+GcpFcLhcaVDppoGFIopKS+sG+pLKALELPGLWNGAMAcWNTlFVEVPltTFNPVKTVNDLL+spHQ	...........h.oppDhc.ltp.......+GIopcplpcQLppFppGFPaLcLpuAAol.p.c.GIhshspcEpcpalstW-s.hppss+plVKFVPASGAASRMFKsLFpFL.............sAth..spPsscFccpFFssIccFAFYccLstsChc.spspslssL.htpspY.KslVssLLpspGLNYGsLPKGLLhFH+Ys.-.ss.RTP.....hEEHLsEuAhYAssp.GcsplHFTVSpEHppLFcphlscphstapc+auVcaploFSpQKPSTDTIAssh-.NpPFRstsGpLLFRPGGHGALIENLNDlDADllFIKNIDNVV....PD+LKs-TlpYKKllAGlLlsLQcpsFpYLchL-su.cho+ppltEllpFlppcLss+p....s.-hcpLp-spLshYL+pKLNRPhRVCGMVKNsGEPGGGPFhshNsDGolSLQILESSQIDhssscppchFcpuTHFNPVDLVCul+DYKGc+FcLscYVDcsTGFIS.KSKsG+-LKALELPGLWNGAMScWNTlFVEVPLsTFNPVKTVNDLLRppHQ..	0	19	41	47
+13977	PF14135	DUF4302		Domain of unknown function (DUF4302)	Bateman A	agb	Jackhmmer:C2M6D7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 344 and 443 amino acids in length. There are two completely conserved residues (R and L) that may be functionally important.	27.00	27.00	40.70	33.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.64	0.70	-4.99	51	186	2011-05-10 16:14:32	2011-05-10 17:14:32	1	2	93	0	30	178	0	240.70	24	56.39	CHANGED	-p-sl.F-c..osupRlspslpphpclL...uutsG.WhhpYYssps..........................aGG.ashhhKFsssp.Vshtu-hs.........sssppssShYplppspu.shLoFDTYN.h.....lHhhupPsssts........pGhpGDa..EFll.....hpsss-..plhlc.......G++stNphhhs....htpstshppahsphppsppthp....hstaphhh...............sspphshthpspppthhhs..hsssp......hphsahhTspG.l.phhpPl....plsGhp.hpphsaspssp	............p-sl.F-c..osupRhppslpchpchL..psuspG.WhhpYasp.ss..........................hGG.ashhhKFsssp.Vshtu-hs..........ssssthsSpYplp.pspu.shLoFsTYN..h.....lHhhusPpttts............tGhtuDa..EFll.....hssss-..plhlc.......G+Kptsphhhs....htpshshcph...hpp.ht.s.hppshp......hhhhphhh.................sspths.hhh.ps.p..t.pthhhs.......hssss.............hshsahhTp...pG....l.p.........hh.pPl.......plsGhp...hppasaspt..p................	0	20	27	30
+13978	PF14136	DUF4303		Domain of unknown function (DUF4303)	Bateman A	agb	Jackhmmer:C2M6J2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 169 and 192 amino acids in length.	21.60	21.60	21.80	21.60	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.89	0.71	-4.58	38	181	2011-05-10 16:15:50	2011-05-10 17:15:50	1	3	156	0	39	155	8	149.60	23	79.57	CHANGED	ltpAs+psapplhp..cpss-shYuauLhosspuhs..lssuAsoc-sLptttp........p..pst..h.........................+Wsss-Wsa...t.sttphFsplsphltphscphp.p.t...........apphhptlhpshlsuLppLcpcGlFust...tph.hlhlslsss-sspt.....ppsctLNss	.....................................................lhpuhpptapplhp..cp.ss-shYua...u...l...h.....oDsssts...lsssANocchlph.pts.........cs...shh...........................+auss.EWsh.......hssht...hFscl...schlpp.h.pphhpps.................aphhhp..plhpthlpsLhcLcp-Gl.Fust....sc..hlhlslsDsssp.hh....ppsphLNs.h..............................................................................	0	6	20	27
+13979	PF14137	DUF4304		Domain of unknown function (DUF4304)	Bateman A	agb	Jackhmmer:C2M6R4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 223 amino acids in length.	22.50	22.50	22.70	22.50	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.55	0.71	-3.98	48	164	2011-05-10 16:19:06	2011-05-10 17:19:06	1	1	144	0	38	153	4	111.30	17	58.01	CHANGED	lsshLKptGFpK.pshsaa+.pppphhtllshQ+sph.........thpFhlNlGlhshthsp................................ph.pthshthpt...Rluslhspt..............s.haplcspp.shp.thhppltp.......tlpphllsah	...................tthL+.hGFpp..pt.s..ah+.pppshhhhlshQ+Sph.................sspFhls..lGlhshtltp..............................................................tt..pp.s..hhhts......+lstlh.pp................hapl..stt....sht.hhtpl.t........lpt.hh..........................................................	0	13	27	31
+13980	PF14138	COX16		Cytochrome c oxidase assembly protein COX16	Bateman A	agb	Jackhmmer:Q5ACH7	Family	This family represents homologues of COX16 [1] which has been shown to be involved in assembly of cytochrome oxidase [2]. Protein in this family are typically between 106 and 134 amino acids in length.	27.00	27.00	27.70	27.70	25.60	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.58	0.72	-3.81	52	253	2011-05-10 16:50:56	2011-05-10 17:50:56	1	11	223	0	174	242	0	79.60	35	58.69	CHANGED	lhaGLPFlhhlVuGSasL..pphoplRY-hpcpKspph.sppEthsht..............pp++cl..slc-E.Yh+l...psh.sh-.........sWE.hRl.R.htE	................lhaGlPhlhllVuGSFsL..ppho.tlRY-ttcpKscp..spc-ththt...............................tpp+cl.....slc-E.Yh............+l....pst..sh-.............................sWEphRl.R.ht-.................	0	47	90	140
+13981	PF14139	YpzG		YpzG-like protein	Eberhardt R	re3	Jackhmmer:C0H444	Family	The YpzG-like protein family includes the B. subtilis YpzG protein Swiss:C0H444 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a conserved QVNG sequence motif.	27.00	27.00	32.20	38.50	17.40	16.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.56	0.72	-4.03	8	104	2011-05-11 07:19:52	2011-05-11 08:19:52	1	1	104	0	17	34	0	49.80	68	98.29	CHANGED	MGp..p+cpaDp...p.YSsPFspPWsNPKHA+uQVNGcTQQoQsLIILcspsRK+p	.......MS...YRDRLDs.....RSELFNHTWTRPKHAKAQVNGQTQQTQSLIILANECKKRQ.	0	3	11	12
+13982	PF14140	YpzI		YpzI-like protein	Eberhardt R	re3	Jackhmmer:C0H446	Family	The YpzI-like protein family includes the B. subtilis YpzI protein Swiss:C0H446 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	27.00	27.00	32.40	58.00	26.20	16.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-8.08	0.72	-4.46	8	121	2011-05-11 07:34:23	2011-05-11 08:34:23	1	1	121	0	13	41	0	41.90	80	91.57	CHANGED	MGKDRQEKKLKtS+RVESDRDQSLpYsGATpL-oPEcARKRN	MGKDRQERKLRESRRVESDRDQSLQYPGATuLDTPEQARKQN..	0	1	8	10
+13983	PF14141	YqzM		YqzM-like protein	Eberhardt R	re3	Jackhmmer:C0H453	Family	The YqzM-like protein family includes the B. subtilis YqzM protein Swiss:C0H453 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	27.00	27.00	33.70	33.60	26.70	25.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.09	0.72	-4.17	11	134	2011-05-11 07:51:06	2011-05-11 08:51:06	1	1	134	0	22	49	0	42.90	79	95.72	CHANGED	NcFE.KDVQsKRNDAlDSuVGFlVSFGFFsslFlIAslIcFlGp	...NDFE.QNVQSKRNDAIDSGVGFIVSFGFFATLFIIATVIKFIGS...	0	6	15	18
+13984	PF14142	YrzO		YrzO-like protein	Eberhardt R	re3	Jackhmmer:C0H458	Family	The YrzO-like protein family includes the B. subtilis YrzO protein Swiss:C0H458 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	100.90	100.80	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.23	0.72	-4.32	2	83	2011-05-11 07:57:22	2011-05-11 08:57:22	1	1	82	0	4	18	0	46.00	90	99.79	CHANGED	MhEuLLFFhusGlsCELAAINRNGRKpIKQQAEhIQlLKE.h.KsI	MLESLLFFFAVGVACELAAINRNGRKKIKQQAEhIQLLKELKER.......	0	1	2	2
+13985	PF14143	YrhC		YrhC-like protein	Eberhardt R	re3	Jackhmmer:O05395	Family	The YrhC-like protein family includes the B. subtilis YrhC protein Swiss:O05395 which is functionally uncharacterised. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine.  Expression of this operon is repressed in the presence of sulphate or cysteine [1]. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	35.80	35.70	25.40	21.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.36	0.72	-4.03	17	134	2011-05-11 08:20:14	2011-05-11 09:20:14	1	1	132	0	19	88	0	71.80	56	89.73	CHANGED	pcLcsKhtDYKpFuhlLLAlSsFLYlGslIP.tuhpsspp.hhhsulslhLshuhhhh+RuhhhpcpLcEt-	...KELppKIEDYoRFGQlLLAVSThLMlGLLIPsGuKEThQhFlMMGoIVIFLuLSFFFFpRVKlhRccLEEsE......	0	2	11	13
+13986	PF14144	DOG1		Seed dormancy control	Coggill P	pcc	Jackhmmer:Q9SN45	Family	This family of plant proteins appears to be a highly specific controller seed dormancy.	27.00	27.00	28.30	27.60	26.40	26.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.77	0.72	-3.94	81	488	2011-05-11 10:20:54	2011-05-11 11:20:54	1	7	52	0	217	469	0	77.90	41	23.87	CHANGED	+plsEL....Rs.ALpup.h...........sDs-L+hlV-sshsHY.pclachKusA...A+sDVF...al.lSGhWpoPsER.sFLWlGGFRPS-Ll+lLhsp	.............................+phsELRsAlpu+h...........sDs-LRh.lV-sshsHY.sclF.chKusA...A+sDVF...al.loGhWpoPuER.sFlWlGGFRPS-ll+llhs.......	0	28	122	175
+13987	PF14145	YrhK		YrhK-like protein	Eberhardt R	re3	Jackhmmer:O05401	Family	The YrhK-like protein family includes the B. subtilis YrhK protein Swiss:O05401 which is functionally uncharacterised.  Its expression is under the control of the motility sigma factor sigma-D [1].  This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.07	0.72	-4.30	57	199	2011-05-11 10:48:16	2011-05-11 11:48:16	1	4	174	0	77	175	13	60.00	30	54.02	CHANGED	hppY-hhth......................lsDhhsulhFllGSlhFhhs.s...ht............hsusWlFllGSlhhhl+Psl+ll+cl+	..................p.ppYchlth............hsDhlhulhFllGSlhFhhc.t...ht........................phGsahFllGSlhhhl+Phl+llpph.h............	1	33	54	71
+13988	PF14146	DUF4305		Domain of unknown function (DUF4305)	Eberhardt R	re3	Jackhmmer:O05524	Family	This family includes the B. subtilis YdiK protein Swiss:O05524, which is functionally uncharacterised.  This is not a homologue of E. coli YdiK, which belongs to Pfam:PF01594.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	27.80	27.80	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.61	0.72	-4.21	20	171	2011-05-11 11:57:29	2011-05-11 12:57:29	1	1	170	0	24	78	0	37.10	43	60.72	CHANGED	llFsYhAlpsss-ss..WshaThllhlhAshDFshul+hl	.hlFTahAlssVsDsh..WshaTILhhlMAshDFslulRLI.	0	6	15	18
+13989	PF14147	Spore_YhaL		Sporulation protein YhaL	Eberhardt R	re3	Jackhmmer:O07520	Family	This family of proteins is involved in sporulation. In B. subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E [1].	27.00	27.00	52.80	52.70	25.70	21.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.60	0.72	-4.52	10	131	2011-05-11 12:12:26	2011-05-11 13:12:26	1	1	131	0	20	58	0	49.50	70	76.14	CHANGED	hPWWVYhlIlGIlFSuYMsl+ouKEE+EhDQcaIE+EGclYMcRlEcERE+R	....hPWWVYLVIlGIlhSGYMVLYTSKKEQ-MDNEFIEKEGEVYMKRLcEEREKR..	0	3	12	14
+13990	PF14148	YhdB		YhdB-like protein	Bateman A	re3	Jackhmmer:O07530	Family	The YhdB-like protein family includes the B. subtilis YhdB protein Swiss:O07530, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 57 and 82 amino acids in length. There are two conserved sequence motifs: LMVRT and FLHAY.	27.00	27.00	74.10	74.00	22.50	21.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.76	0.72	-4.23	6	132	2011-05-11 12:24:37	2011-05-11 13:24:37	1	1	131	0	16	43	0	69.50	71	93.88	CHANGED	Ms.hsDYDKALYYTaRSpWDsLLILMVRTKDDLLSKRIE+FLHAYpFp+Das.V-KpL.sLLpYIDHA..hoshpppEt	...p.h.DYD+ALYYTapspWDpLLlLMVQTsDQLFSKRIEHFLHAYQYSKELPEVDKQLQLLFQYIDHASQKSHlEElE.Q.......	0	1	8	10
+13991	PF14149	YhfH		YhfH-like protein	Eberhardt R	re3	Jackhmmer:O07606	Family	The YhfH-like protein family includes the B. subtilis YhfH protein Swiss:O07606, which is functionally uncharacterised. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response [1].  This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 53 amino acids in length.	27.00	27.00	27.00	30.00	26.90	25.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-7.99	0.72	-4.16	17	140	2011-05-11 12:36:23	2011-05-11 13:36:23	1	1	127	0	25	77	0	36.90	66	75.72	CHANGED	lpphsEFFRNLPsKpCscCGcc.I-EQpEsYtspC-cC	............-pshEFFRNLPoKsCAcCGKE.IDEQHEuYpNcCDDC	0	8	19	22
+13992	PF14150	YesK		YesK-like protein	Eberhardt R	re3	Jackhmmer:O31514	Family	The YesK-like protein family includes the B. subtilis YesK protein Swiss:O31514, which is functionally uncharacterised.  Its expression is regulated by the sporulation-specific sigma factor sigma-E [1].  This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	25.00	25.00	26.60	26.20	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.69	0.72	-3.88	10	127	2011-05-11 12:48:56	2011-05-11 13:48:56	1	1	108	0	12	74	0	76.40	57	81.94	CHANGED	FallGhlohlllFslShll+++aPsKp.h-hlLuhlLIllslhslhlSlFllGGWEGhGlGlluhhlllGolIGhIActhl+	........FYIIGGlTIlLVFAIS..YLLKKRFPDKQ..FDIIFALuLILLCLAoFPVTMhlIGGWEGMGYGFIGFFVLLGTLIGMIAHQLlK........	0	1	8	8
+13993	PF14151	YfhD		YfhD-like protein	Eberhardt R	re3	Jackhmmer:O31572	Family	The YfhD-like protein family includes the B. subtilis YfhD protein Swiss:O31572, which is functionally uncharacterised.  Its expression is regulated by the sporulation-specific sigma factor sigma-F [1].  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	27.00	38.20	26.50	26.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.11	0.72	-3.86	16	145	2011-05-11 12:59:37	2011-05-11 13:59:37	1	1	141	0	27	79	0	54.30	55	99.03	CHANGED	MsRsptpKs+cK.NctphsQsPct....uDuhDVEFSpElADp-DhEApsRupAADtRt........pppcp	........................................scpph.p.sKs......oDGlDVEFS+ELADHsDLEApARAsAADsRQK...p....sp........	0	4	17	19
+13994	PF14152	YfhE		YfhE-like protein	Bateman A	re3	Jackhmmer:O31573	Family	The YfhE-like protein family includes the B. subtilis YfhE protein Swiss:O31573, which is functionally uncharacterised.  Its expression may be regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins [1].  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved QEV sequence motif.	27.00	27.00	36.90	36.50	19.80	18.50	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.75	0.72	-4.05	13	126	2011-05-11 13:10:06	2011-05-11 14:10:06	1	1	124	0	15	42	0	36.60	66	92.22	CHANGED	-.....K++pccs+soLopsQEVpYup-FKtAD+A..u..pt++	............DKKKRDKsKNsLSSTQEVLYQREF+KADRA..AGYRuKS.........	0	2	8	10
+13995	PF14153	Spore_coat_CotO		Spore coat protein CotO	Eberhardt R	re3	Jackhmmer:O31622	Family	Bacillus spores are protected by a protein shell consisting of over 50 different polypeptides, known as the coat.  This family of proteins has an important morphogenetic role in coat assembly, it is involved in the assembly of at least 5 different coat proteins including CotB, CotG, CotS, CotSA and CotW. It is likely to act at a late stage of coat assembly [1].	35.00	35.00	43.30	40.20	34.00	33.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.20	0.71	-4.85	16	142	2011-05-11 14:03:18	2011-05-11 15:03:18	1	2	126	0	22	123	0	159.60	42	98.69	CHANGED	s+cph.....scpcPLLYIsQPchpc.spspMQcsaht+pcppp..................ttppptppp...................p........p..t....t...p..p..t..tppttppp..........................................................h.hcKsFpcMsl-EKIsFLsphPcplPslpCplhocpcoYcGllhshcss...plhltss......tpt..spsplsh-cIhSlphlGF	...............................................ps..Ks.p..sssKPLLYIsQssh-h.ussphpcIllsphcscs....................pcEppscscph......t...pth.E.ppppt..............pcp.tp..p..tp.p.p..ppppc.s.......................................................psh.hpKsF+-Ms.-EKIcFLhshPHalP+l+CcIcTsshoYhGsIluhRNG...hVsIhss......ssh..c-hcLuI--IpSIsMhGF........	0	1	11	14
+13996	PF14154	DUF4306		Domain of unknown function (DUF4306)	Eberhardt R	re3	Jackhmmer:O31651	Family	This family includes the B. subtilis YjdJ protein Swiss:O05524, which is functionally uncharacterised.  This is not a homologue of E. coli YjdJ, which belongs to Pfam:PF00583.  This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 152 amino acids in length.	27.00	27.00	44.90	44.30	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.90	0.72	-4.01	8	123	2011-05-11 14:12:19	2011-05-11 15:12:19	1	2	99	0	11	90	0	87.50	47	78.91	CHANGED	hlQaGhuhhlFlFSAlsoWYpGSpLlsssa-WKaoshFophh.G..slss.cpISQLDaFlYAAKapPshsslMllShlYlLsLlhhhlhp	.....hlQhu.uhhlFlhSAL.ho.WYQGSsLl-sP.EWKYoAKFTshhp.G..TVoshcDIYQIDFFlYAAKFYPsshIVMllSlLYhLlLIlahlh.........	0	1	5	7
+13997	PF14155	DUF4307		Domain of unknown function (DUF4307)	Bateman A	agb	Jackhmmer:C7PZ49	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	27.00	27.00	38.70	52.60	25.50	23.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.34	0.71	-4.28	57	347	2011-05-11 14:48:55	2011-05-11 15:48:55	1	1	343	0	86	210	61	112.00	31	78.09	CHANGED	pscpthhslsslhslsuhshhuh..hsapphusssl..suphluacllsDs.psplphpVs+s.s..upsuhChVcAhspctuEVGRc-lhl....ss......ssppphchssslcTsp.ussuclh.GC	......tcthhhlll.hVLsllhhshhsh...huhp.h.us..ssl..puplhGaphl...sD.s.pssVTlpVpRsDP..ShsusChVpAput-tuEVGR+-lhl...Ps..........ussps.plpssV+Tpp.uVsu-lhuC...	0	26	65	82
+13998	PF14156	AbbA_antirepres		Antirepressor AbbA	Eberhardt R	re3	Jackhmmer:O31697	Family	This family inactivates the repressor AbrB, which represses genes switched on during the transition from the exponential to the stationary phase of growth.  It binds to AbrB and prevents it from binding to DNA [1].	27.00	27.00	54.50	54.40	23.20	21.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.05	0.72	-4.32	6	115	2011-05-11 14:58:50	2011-05-11 15:58:50	1	1	115	0	12	35	0	61.00	70	96.46	CHANGED	Mp+cls...LTpEEppLLLDILFpQpYAhElLusELsDIEsGhKpsDhppY++lsRLasRL+sE	.Mp+EhV...LTcEEESLLLDILFQQNYASEILAVELTDIENGLKpTDVhQYKKITRLFYRLKNK.	0	1	4	6
+13999	PF14157	YmzC		YmzC-like protein	Eberhardt R	re3	Jackhmmer:O31797	Family	The YmzC-like protein family includes the B. subtilis YmzC protein Swiss:O31797, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 91 amino acids in length. There is a conserved ELR sequence motif.	27.00	27.00	35.10	34.60	25.60	20.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-8.97	0.72	-4.15	7	102	2011-05-11 15:18:03	2011-05-11 16:18:03	1	1	94	6	6	68	0	58.60	57	69.31	CHANGED	hNpEpllEh.ssas.....os.psppssMsQltcNpFAlh.......-csplKIa+as.cTNclpLlKEass-E	......spEpsVEh.ssas.....Ss..hsTssMTQlu-NTFAhp......sEsspIKIFKFNPDTNEIKLIKEFhusE...	0	1	3	3
+14000	PF14158	YndJ		YndJ-like protein	Eberhardt R	re3	Jackhmmer:O31813	Family	The YndJ-like protein family includes the B. subtilis YndJ protein Swiss:O31813, which is functionally uncharacterised. This family is found in bacteria and archaea, and is typically between 222 and 269 amino acids in length. There are two completely conserved G residues that may be functionally important.	27.00	27.00	42.30	41.70	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.69	0.70	-5.33	14	139	2011-05-11 15:24:24	2011-05-11 16:24:24	1	2	133	0	21	118	0	248.50	55	50.67	CHANGED	shssspthlhLusLhhlPhshphh.pts......h..shhh+....h.PluAlsAshuhshs.....tshhAssWhshsshhAlhussRl.......hpRshc....hpElulsuullYlssGuhWhhstsuslslhtFu..IlhLTAsHFHauuFshPlhsGLLGRt.t.......tct.hlaphhshhIhluPhh.lAlGIshSchh-hhushlhssAlhuhuhhshtps......hcspsuthLltluuhsLhholshuhhYuhGphhupshl.sIspMlhhHGssNAhuV	...........slsslEAIlLLSlLLFlPhohsllDKcs....RsGu.llFYK.VShLYPIAAIsAhLAFVTs.......thhFAllWFlYTGl.....lAL...FGlsRL.......................LERGh+P.................LEEsAIDSAFIYLFLGGFWFFASVA+lo.IMpFSsDIlLLTAAHFHYSAFLLPLSAGLlG.RK+c............KpS..KlYcsIhalIhISPMT.VAIGITYSRl.....FEFFAVhLYLsAIYuYuh.YVW+s+......FsuloAKILLllSSoTLMlTIhFSLIYSYGNh+pVhTI.TIAQMVWIHGVVNGlGV.......	0	7	14	18
+14001	PF14159	CAAD	DUF4308;	CAAD domains of cyanobacterial aminoacyl-tRNA synthetase	Bateman A	agb	Jackhmmer:B1XK71	Domain	This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids [1]. aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-, and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during evolution.	27.00	27.00	27.70	27.70	25.70	26.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.78	0.72	-4.34	96	289	2011-05-11 16:33:04	2011-05-11 17:33:04	1	7	100	0	141	276	113	86.30	31	38.78	CHANGED	lspl.pthsph..sphphshhshuhhhh.llslhlssullsAIsplPLlsslh....ELlGluYosWFsaRhLlhppsRp-Lhpclp..................shcpp.....lhG	........................h..pl.phhsph..sphphhhhssuh....llulhlssullsAIsplPLlPsl.h....ELVGlG..YouWFsaRaLlhppsRc-Lhsclp...............sl+pplhG........................	0	22	85	123
+14002	PF14160	FAM110_C		Centrosome-associated C terminus	Coggill P	pcc	Jackhmmer:Q8TC76	Family	This is the C-terminus of a family of proteins that colocalise with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.	21.00	21.00	22.10	23.30	20.00	17.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.67	0.71	-3.13	16	181	2011-05-11 17:01:40	2011-05-11 18:01:40	1	2	70	0	114	169	0	111.10	43	28.84	CHANGED	p+.psuLpRSKS..DlSc.RaStutu-lE+FFsaCGLDsp.l-tLGh.-shtpss....S..DhsSl.phcSsossuS-.s......tpopcSs.-.sh.............pE-tts-RlP.GlSlIERNARVIKWLYup+pA+	.................................s.psuLpRSKS..DLSs.Rauc.....shu-lERFFsaCGLDPEtl-sLG.h...EpF.upus...................S..DhsSl....shpSsossoS-.s..............tpSpc.Ss..s.sh........................................t--...pst-RV.....P....u.lSllERNARlIKWLYuh+pA+..........	1	14	22	61
+14003	PF14161	FAM110_N		Centrosome-associated N terminus	Coggill P	pcc	Jackhmmer:Q8TC76	Family	This is the N-terminus of a family of proteins that colocalise with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.	22.20	22.20	22.20	22.20	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.39	0.72	-3.79	5	153	2011-05-11 17:02:04	2011-05-11 18:02:04	1	2	49	0	93	142	0	103.50	38	31.34	CHANGED	s.uK....PluPAGPh.ouAVPLRILNKGP-YF.R.RQA..EssP+RhSAVERLEADKAKYVKSQEVINAKQEPVK..PPVLt.KPhsSPu.....PKRuu....uoP....ohKApss.puKo-SG.u......+RsNLcL	.....................................hs...ssshP.hRlhsKsP...s..Yh..R...R.s...-..s...s..s..+..+.....hSAVERLEADKAKYVKSppVlss+QE.P.Vp.....sslht..pP..hsss......spt.sh.........tP.....sh+..........................................................................................	0	8	16	47
+14004	PF14162	YozD		YozD-like protein	Eberhardt R	re3	Jackhmmer:O31863	Family	The YozD-like protein family includes the B. subtilis YozD protein Swiss:O31863, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	92.00	91.90	23.60	17.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.75	0.72	-3.89	6	127	2011-05-12 07:20:28	2011-05-12 08:20:28	1	1	127	0	15	38	0	56.90	81	96.98	CHANGED	MKEIEVVIDTEEIAEFFYpELlRRGYVPoE-ElEElADITF-YLlEKChIDEEh---	.MKEIEVVIDTEEIAEFFYEQLIERGYVPKREEIEDLADITFEYLLEKCMIDEVFDEE..	0	1	7	9
+14005	PF14163	SieB		Superinfection exclusion protein B	Eberhardt R	re3	Jackhmmer:O31930	Family	This family includes superinfection exclusion proteins. These proteins prevent the growth of superinfecting phage which are insensitive to repression. It aborts lytic development of superinfecting phage [1-3].	26.00	26.00	26.10	26.10	25.90	25.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.42	0.71	-4.64	34	252	2011-05-12 07:43:39	2011-05-12 08:43:39	1	1	226	0	34	153	4	143.90	25	82.81	CHANGED	hhhhLslhsuhLL....hhPpshlphlslsphhsp...at.alGlshllusAallspllshh....hp.hhph......hpp++phctlccp.....lptLsspE+slLppahhps..pphlpLshssssVpsLhppsIlphhust........ssttphplshphpsahpcpltphspt	.................hahllIhhh..hll....lhPsshhphlsltp..hh....t.ahahlllhslSallstslsph.......hcthh.t........pp+ptpcphtph.......hpsL..o.tE..pAlL.t.hltss...p.l....ph.pssPhshpLhc+Gllp+hsss........sspstahIs-papp.hhhthtsc...t.......................................	0	8	16	23
+14006	PF14164	YqzH		YqzH-like protein	Eberhardt R	re3	Jackhmmer:O32014	Family	The YqzH-like protein family includes the B. subtilis YqzH protein Swiss:O32014, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	27.80	40.00	23.90	20.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-9.00	0.72	-4.06	9	119	2011-05-12 07:53:05	2011-05-12 08:53:05	1	1	119	0	12	63	0	60.80	59	94.71	CHANGED	MsEKhIcKhltpshcQYu.s.pshPlosp-hcpLhcpIppthspcs-hDlYEhlcDlVY-YlTu	.MNEKLIEKMIIKSFQQY....QCsPlSpEDQEMLlKHIQslhHSNscIDlYEtlEDIVYDYVTG.	0	2	4	6
+14007	PF14165	YtzH		YtzH-like protein	Eberhardt R	re3	Jackhmmer:O32066	Family	The YtzH-like protein family includes the B. subtilis YtzH protein Swiss:O32066, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved DIL sequence motif.	27.00	27.00	38.30	71.50	20.90	18.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.80	0.72	-3.75	14	132	2011-05-12 07:58:12	2011-05-12 08:58:12	1	1	132	0	21	51	0	86.70	69	94.45	CHANGED	LsppHQLsLL+DILssHpsDCsGTVuEsEQlERLlpSLhsNssl.ssslKslLpcI....YsYuQsGh.utslssHIstppppLspWlssls	..INQQHQLEVLKDILlNHQSDCCGTVSECEQLERLIQSLLANDsI.SSDsKsMLNDV....YSYSQSGKSSSNLDNHISNNQEQLTQWIuGMD.	0	4	13	15
+14008	PF14166	YueH		YueH-like protein	Eberhardt R	re3	Jackhmmer:O32093	Family	The YueH-like protein family includes the B. subtilis YueH protein Swiss:O32093, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	38.30	38.00	26.70	23.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.72	0.72	-4.22	17	252	2011-05-12 08:07:03	2011-05-12 09:07:03	1	1	252	0	16	76	0	75.00	57	93.12	CHANGED	KI...chhptps.hhsVYlaEscccp.hllAIPslpWShplshp.-ppplt-cLhhpLhphh-EppAppLAsplspWlpc	......hl....NKRhlDEGKTIDVYLFEulNsQ.IIIAIPDWFWSYQMAMTL....DEETCFEAILMQLF..VFKEEEEAESIASQLTDWIET...	0	2	5	12
+14009	PF14167	YfkD		YfkD-like protein	Eberhardt R	re3	Jackhmmer:O34579	Family	The YfkD-like protein family includes the B. subtilis YfkD protein Swiss:O34579, which is functionally uncharacterised.  Its expression is regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins, and by the forespore-specific sigma factor sigma-G [1,2]. This family of proteins is found in bacteria. Proteins in this family are typically between 254 and 265 amino acids in length.	27.00	27.00	29.90	29.60	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.59	0.70	-5.29	10	138	2011-05-12 08:22:59	2011-05-12 09:22:59	1	1	137	0	20	94	0	229.10	72	89.47	CHANGED	PsSVlsISKENTYPNPTQDLPhLQPS-LAcpLL-oo-VKIENP-LIRhLNESSIsuoPLAIGYRAoIYLGpWPLsYESsETssNWEYQKVNTNhlDNRGGpuspplpYpQEpQK+V+GGLTAcIPNu--VKKMMLlKAtEKTsLPLAFcTVIGtGTKK-psYsVsPK+lGYLauYsPAVNEKGKVTYGEVYLsLKGsK++LsVKNVTpQGIGAWIPVQD+lSFuFhsSspP+	.....PSSVLNISKDNTaPN-AQDLPRLQPSKFAQELLKTANIKIENPDLIRMFNETTISNAPLAVGYRAKIYLGQWALpYESlDTSlNWEYKQVNRNVYDNRGGD+LYPLRYKQEoQKTVEGsLTAchKcAsDVKKMMLLKAhEKVQLPLSFKTTIGYGTG+ERVYNISPsQLGYLYAYTPAVNEKGKVTFGEVYLVLKGNQK+LVVKNlTSQGIGAuIPIpDHLaFKFlSSS+s.p.............................	0	3	12	14
+14010	PF14168	YjzC		YjzC-like protein	Eberhardt R	re3	Jackhmmer:O34585	Family	The YjzC-like protein family includes the B. subtilis YjzC protein Swiss:O34585, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	25.30	25.20	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.60	0.72	-4.04	20	212	2011-05-12 09:55:35	2011-05-12 10:55:35	1	1	206	0	28	102	0	56.70	51	92.41	CHANGED	M......G............p.....pp.F+PGp+APNsGhYl.ElGt.pGut..VpsP+pVclctGD+FP-ToN+sR..+Wpp.+	..............MGppppF+sGpKA.PNs.GlY.....V.ElG-.sGuh....Vp.sPphlpLstG-+FP-To..N+sR..tWph......	0	8	18	20
+14011	PF14169	YdjO		Cold-inducible protein YdjO	Eberhardt R	re3	Jackhmmer:O34759	Family	This family includes the B. subtilis YdjO protein Swiss:O34759, which is functionally uncharacterised. This is not a homologue of E. coli YdjO, Swiss:P76210.  B. subtilis YdjO is cold-inducible [1]. Its expression is induced by the extracytoplasmic function sigma factor sigma-W [2].  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	28.10	30.90	24.00	26.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.35	0.72	-4.52	15	173	2011-05-12 10:24:33	2011-05-12 11:24:33	1	2	128	0	30	85	0	59.30	52	59.05	CHANGED	MYapK+spEslPcEp...TsVWpCouEDCpGWMRcNFoh--pPhCPLCpSsMhsupRhLspl	........h.RKpshtplP.Ep.....TsVWECpuEDChGWMR......KNF.........o.........a......EEc..........PpCPLC+SsMpsGpRhLPpL..	0	8	19	20
+14013	PF14171	SpoIISA_toxin		Toxin SpoIISA, type II toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:O34853	Family	SpoIISA is a toxin which causes lysis of vegetatively growing cells.  It forms part of a type II toxin-antitoxin system, where the SpoIISB protein, Pfam:PF14185, acts as an antitoxin. It is a transmembrane protein, with a cytoplasmic domain accounting for approximately two-thirds of the protein. The structure of the cytoplasmic domain resembles that of the GAF domains, Pfam: PF01590. SpoIISB binds to the cytoplasmic domain of SpoIISA with high affinity [1].	27.00	27.00	32.30	32.20	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.41	0.70	-5.11	7	118	2011-05-12 10:56:17	2011-05-12 11:56:17	1	1	113	2	13	77	0	239.80	59	97.97	CHANGED	lLFFQhhV..........WlllhuLhlY.VaAsWRaEtplcE+hhsIRKTWYhLaVhGuslaWTa-PpSlFTcWpcYLIlAVhFsllDAFIFLouYlpKluusE..hpTDTcpllEcNs-hL+hhhs+LKsaphLLKs-sIHlY....YGoh-AYhpGlccllttaA-KhslpAulh.assptsKDcLhcp..................hcpptslpscLsRp-VYYpppsKlVlIP.FolpsppaVlKLoS-sllTEFDhLLhsSLssIYDLlhs	...............NIRIG.......l..........FlLAIVFlVL.VF..FYW+NEELYEEKKQRI...RKTWYGLFIlSVTVYFMIKGID.LTLWKNLLMFTAMVIFVDIAFILTPNISEIWGAK....FSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPuVFGT..MEWHTEEEYTKSLNsFLDSYGEKIGAKIVVFEAAKELNTN..F.Rsh+sp.............................FSh.IlPlEaIEQLNEQ+AV..QVENVGIIP.AKIV.SDVFIVI.D...GKKNNLQDRDFENVYNLTIHHSYFS.K....	0	2	8	9
+14014	PF14172	DUF4309		Domain of unknown function (DUF4309)	Eberhardt R	re3	Jackhmmer:O34960	Family	This family includes the B. subtilis YjgB protein Swiss:O34960, which is functionally uncharacterised. This is not a homologue of E. coli YjgB, Swiss: P27250. Expression of B. subtilis YjgB is regulated by the alternative transcription factor sigma-B [1]. This family is found in bacteria, and is approximately 140 amino acids in length.	25.00	25.00	25.10	25.00	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.63	0.71	-4.18	15	166	2011-05-12 12:03:59	2011-05-12 13:03:59	1	4	156	0	29	141	1	131.10	44	57.89	CHANGED	hlpslhchAhcGclss..ssFslspushpDVp+phGcP-psshsusuhshYtsatu.hsluFGasKsspIhElRSFssslc......ulTlpclcptlGpPspshTs....sc-pIh.....sY+sGppYcLcFVassssst......lDHlSlh	.......h.lcsla-hAccGK..VP.N..ssFuspTusI--lcKsWGKs-+s-tuusu..hY.Aoass..+slsFG.aNKGuQlF-lRSacscLK.............uITLp-lcKsLGcPsplpss............uc-cIY.....VY+..lss....paEL+FlIscoTup..................lcHlSVh.............	0	10	22	22
+14015	PF14173	ComGG		ComG operon protein 7	Eberhardt R	re3	Jackhmmer:P25959	Family	This family is required for DNA-binding during transformation of competent bacterial cells [1].	25.00	25.00	25.30	25.00	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.89	0.72	-3.78	18	125	2011-05-12 12:37:24	2011-05-12 13:37:24	1	1	125	0	20	93	0	94.30	38	78.36	CHANGED	hahsEpphhpppcphhch-pLlphulh-lppclt...pspptpssphpa.cGplsa.phscps.tshhplslpspsssGhphsspFhhshtspcIhc.WpE	............hhs-KpFhpEhEQpalh-ELLppulssl.K+-Lp.......pcEK.csshhFpYc+GcsSh.pashEs...-hIhVsLQCphK.ppshYpVsFpYc+KcpKIh-WlE..........	0	4	12	14
+14016	PF14174	YycC		YycC-like protein	Eberhardt R	re3	Jackhmmer:P37481	Family	The YycC-like protein family includes the B. subtilis YycC protein Swiss:P37481, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a conserved HIL sequence motif.	27.00	27.00	28.70	64.30	22.30	21.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.66	0.72	-4.29	13	148	2011-05-12 12:50:22	2011-05-12 13:50:22	1	1	148	0	26	62	0	49.30	75	97.51	CHANGED	MRPLQISsETAl+LucpLsVPLEplMHMPpHILlQKlhEL.................ptppppcccs	.MRPLQISPDTAV+LSKALGVPLEQLMHMPQHILlQKLlEL.............EKpNK-.......-E.........	0	6	15	18
+14017	PF14175	YaaC		YaaC-like Protein	Eberhardt R	re3	Jackhmmer:P37526	Family	The YaaC-like protein family includes the B. subtilis YaaC protein Swiss:P37526, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 320 and 333 amino acids in length.	27.00	27.00	32.80	30.40	20.30	24.10	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.04	0.70	-5.47	27	147	2011-05-12 13:03:11	2011-05-12 14:03:11	1	2	139	0	32	142	3	284.50	38	91.65	CHANGED	hpplthapohphsppaLtppapp..htpspppuhpss.shlaalcpupsaYctuptu.slpl+PlLLaYGhhpLlKAhLLstssshs.....pposlluHGloo+cp+cpsaphhpc......cV+lpcs...G...laschscplh.......thpthpsEc........ashtcLLtpIPElppha........ptpphh.lclthhppp.......hhhspphhsphp...hstpcFhphhpppppthh.........ppppcpthhhp.s........................hp.hhstslhhphpstpaal.h...tpsthhplPplhhHYLlLYsLShlsRYcs-hWt-LLpup.spchshIppFLshstcphPhhltphl	............................WppLshFhSsppsQcaLtcsYpc..shppuccpSacNshsFlYaLcHucsaYchhphu.PhsIpPhLLFYGhsQLhKACLLThDPsYP.....psToVLAHGVTTRKRKKQsYpFh-D......EVKlQ+N...G...LFsHhucpLF...................phcplpsE+........asMhcLhtpIPELpslF......hhppctthhhclpp.ppp.......lshs.pllcph+...MoppRFscYlpp.hpth...............tcppppplhFpss.pt.......................hpshhssslhach.sspYalPh....+s..t.hLPElllHYLLLYNLSMIuRYET-WWh-LLt.uasSc.-YshIhpFLslotpKhPhhlsphl........................	0	10	22	26
+14018	PF14176	YxiJ		YxiJ-like protein	Eberhardt R	re3	Jackhmmer:P42320	Family	The YxiJ-like protein family includes the B. subtilis YxiJ protein Swiss:P42320, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	27.00	27.00	31.00	36.50	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.43	0.72	-3.93	8	95	2011-05-12 13:10:07	2011-05-12 14:10:07	1	1	90	0	7	61	1	103.30	58	87.22	CHANGED	lpELc.+hp..LcpPFPscslp+lp.sh........-ssshssDFhpaaslluGSLSYVLss..K+IPcpQh+hLcKSFFEhYPQYc.LcscItpY.cLacclpsaEcTRcLLlt	.......FpELQ.KM+SPLaKPFPspshpKlp+DhpshF....TEDDCIsADhNaYWMHTAGTLSYVLNNNEQcIsFpQIKWL+KSFFEWFPQYpFLETEIhcYPILYRDFhsYEKTRKLLLY.....	0	2	6	6
+14019	PF14177	YkyB		YkyB-like protein	Eberhardt R	re3	Jackhmmer:P42430	Family	The YkyB-like protein family includes the B. subtilis YkyB protein Swiss:P42430, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There are two conserved sequence motifs: NRHAKTA and HLG.	27.00	27.00	28.50	27.50	19.50	21.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.83	0.71	-4.04	9	140	2011-05-12 13:17:39	2011-05-12 14:17:39	1	1	137	0	20	74	0	135.60	65	88.32	CHANGED	Tl-NLupAlFTVNRHAKTAhNP+aLYhLKK+AlpKLlcEGKA+KlGLHFSpNP+aSQQpSDVLVplGs......YaFHlPPsKcDFcpLPHLGsLspSaRNP+s+MsLspAKpLLppYsGhKpc..pss+...ppppYpKPsa++LG-	........s.IspLAQuIFlVNRHAKAATNPKYLYhLKKpALE+LIs.EcKAlKEGLH...FSR.NPRFS..QQQSDVLI+LGD......YFFHIPPTKEDF+hLPHLG+LE..SS..YRNPK..TTLSLTlAKKsLQ-YlG.cshc.ppp+..scss.............hh............	0	1	11	14
+14020	PF14178	YppF		YppF-like protein	Eberhardt R	re3	Jackhmmer:P50834	Family	The YppF-like protein family includes the B. subtilis YppF protein Swiss:P50834, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved LLDF sequence motif.	24.70	24.70	24.70	43.70	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.73	0.72	-4.44	9	125	2011-05-12 13:26:50	2011-05-12 14:26:50	1	1	123	0	15	45	0	59.80	62	92.84	CHANGED	Msls-L+ppFhphKpYpPtshNELLDFAR+hYlcGcIsIs-YRsLl+ELEtsGAspPspp	MVLGDLKQAFSQKKGYtTENsNELLDFARHhYLEGKICISDYRTlIKELEINGATKPTT.h...	0	1	6	9
+14021	PF14179	YppG		YppG-like protein	Eberhardt R	re3	Jackhmmer:P50835	Family	The YppG-like protein family includes the B. subtilis YppG protein Swiss:P50835, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.	27.00	27.00	28.90	38.40	22.20	21.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.93	0.71	-3.47	18	134	2011-05-12 13:35:43	2011-05-12 14:35:43	1	1	133	0	20	101	0	128.70	55	86.65	CHANGED	psaptsh.sahP.t...........................tp.pPYhp.s.pt...............................tPs.s.p.Ptttph..h.s..h....pPY.Pp.ps.h..p.P....sphpShhuQFKsp-Gs..aDhNKMhsTsGQhhsssN.......QVuullKGlsuhFK	..........................................p.tsYh..p.......................................................Q.pQPYhspt........t...................................hP..s.sPYsNQQuMFYPP.K............QPY.PTtsKQK....QQQP.....SQFSSFVSQFKsSDGN..YDVNKMMNTAGQMMNAMNQVTGIVKQVGGFF.u.......	0	3	13	15
+14023	PF14181	YqfQ		YqfQ-like protein	Eberhardt R	re3	Jackhmmer:P54474	Family	The YqfQ-like protein family includes the B. subtilis YqfQ protein Swiss:P54474, also known as VrrA, which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 237 amino acids in length. There are two conserved sequence motifs: QYGP and PKLY.	27.00	27.00	27.20	29.10	23.30	26.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.35	0.71	-4.20	17	138	2011-05-12 13:47:31	2011-05-12 14:47:31	1	1	131	0	22	119	0	165.80	41	84.95	CHANGED	tGhLu+Lhstu..............thtu........................................................uuusts.suussuu...htshhs..slosMLsNlQKsLulAQpVsPM...VQQYGPLlRNLPuMh+l...a+pLssucs....tsppsspcssspppppp..t.psppppcpccph.pspppctppcppsst.p.......................SpPKLYl	..........................................tGhLu+hh.tt...........s.pthtu...................................................................htssts+GuAsss.....AuuSuGhGuhhuNLhS..N..sosMlNNlpKV.pVsQoVuPh...VpQYGPlhRNLPSllKI...hpthpSscp......spEspsEchoEpsEstossss........ppKc++KKhl.csshc+ph.c.psspphs......................oKPKLYl.....................................	0	4	14	16
+14024	PF14182	YgaB		YgaB-like protein	Eberhardt R	re3	Jackhmmer:P71080	Family	The YgaB-like protein family includes the B. subtilis YgaB protein Swiss:P71080, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	27.00	27.00	37.50	37.20	24.10	23.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.79	0.72	-3.74	11	129	2011-05-12 13:57:44	2011-05-12 14:57:44	1	1	129	0	14	60	0	78.00	63	90.65	CHANGED	pF-+LVuEQhcTMDcLLpLQSELERCQpIE+pLhchpccscLpsIppEIppp+ccL+pIQchFpKQTEpVIpSYppp.....Eh	............DFDKLVGEQLETMDELLKLQuHLEKYQQIEhsE+-pCDKKELHFIRQEIYRTElALKhLHEKFEcQTNsVIQSFcTEK.h...	0	1	6	8
+14025	PF14183	YwpF		YwpF-like protein	Eberhardt R	re3	Jackhmmer:P94588	Family	The YwpF-like protein family includes the B. subtilis YwpF protein Swiss:P94588, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.	27.00	27.00	52.20	129.70	23.70	22.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.57	0.71	-4.45	21	269	2011-05-12 14:41:30	2011-05-12 15:41:30	1	1	269	0	30	86	0	132.30	70	88.58	CHANGED	KTFKLlsLpll...pcpt.....php-hsLhDGLIINKEcupspWLlEsllsppatshFcphhppppplplpVsIT+tsN-PAthhssV+sIscl...scplSVLh-Gpllpp+.pshuEplLcsLlcEGlsG-pLlcp.FKpph	..KTFKAVRFQIV...NEHG.....RIIEYELEDGVIINKE-SGTGWLLEIVISNEHYETFKEYQDNEQLLDIRVVITRPANDPALF-oTVKSIKNF...KTTMSIVFECHIY.TLR.QQYAESLLEQLIDDGLSGEELKKoFNRMM...	0	7	17	26
+14026	PF14184	YrvL		Regulatory protein YrvL	Eberhardt R	re3	Jackhmmer:Q7WY71	Family	YrvL prevents expression and activity of the YrvI sigma factor. It may function as an anti-sigma factor [1,2]	27.00	27.00	27.40	27.20	22.70	21.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.77	0.71	-4.36	16	154	2011-05-12 15:00:41	2011-05-12 16:00:41	1	1	131	0	16	108	1	118.50	39	91.84	CHANGED	htphhhlhlhhslhhhllhuhhhhshsulFplhGhpYpShsullLFhllhhlL...uhhl-hht+sllpslhph.hhsphhhhlLhhhl-hhhsahslahsDpahcSlplsshsclllulhhallshhhsp..............cpp	............h..hhhlh.hhhlhlhllFuh.hFFlhhGlFplhGlpYpShsuLLLFhLlhhhL....shhh....hh+hllhshtpt..hsphlslhL..hull-lhhsWhsIHhAD-aI-SVplSshsElslsLhhalLsKhhsc.....c.....ct.........	0	5	9	11
+14027	PF14185	SpoIISB_antitox		Antitoxin SpoIISB, type II toxin-antitoxin system 	Eberhardt R	re3	Jackhmmer:O34800	Family	Members of this family act as antitoxins. They bind to the SpoIISA toxin, Pfam:PF14171. They are disordered proteins which adopt structure only when bound to SpoIISA [1].	27.00	27.00	48.60	48.40	24.20	23.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.84	0.72	-4.22	5	24	2011-05-12 15:08:58	2011-05-12 16:08:58	1	1	24	2	5	17	0	55.60	70	98.31	CHANGED	MEpAFQscpps.++tpPFKhlKK+SpTSlAcYcVSPHTcRIFKcNERLIDEYKpKKA	..........MEpAFQNspp..+tAKPFKhhKKRSpTSlASYQVSPHTARIFKENERLIDcYKpKKA.	0	1	2	3
+14028	PF14186	Aida_C2		Cytoskeletal adhesion	Coggill P	pcc	Zhang D, Aravind L	Domain	This is the C-terminal domain of the axin-interacting protein family, and is a distinct version of the C2 domain. This domain is critical for interactions with cytoskeletal in the context of cellular adhesion points [2].	25.00	25.00	40.30	27.90	23.70	22.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.66	0.71	-4.95	11	105	2012-10-10 12:23:49	2011-05-12 16:14:55	1	12	62	3	71	90	0	136.50	53	24.73	CHANGED	uohhPshsppsGsstLslhI-+lu.lKDAspahsPahoVoVhDssGpslpssQ-TPlu..pp+sssalhFs.sslplQsslcchsc.GuAlhhEF+HYKsKK+KhSs+CWuFMEhD-l+sG....ssslElYtKPTDh+R.KKlpLlotKshaL+lphp	.......................................uoLlPtlsppPGhThLol+IEKIG.LKDAuph..ID..PahTVS.VKDhsGhDLsssQDTPVA....s++E-sYlaFs.sslclQ+pl....EKLsK.GAA.IFFEFKHYKPK..KRhTSTK...........CFAFMEM..DEIKsG............PlVIELYKKPTDFKR..KKLpLLTcKPLYLHLp.o..............................................	0	20	28	43
+14029	PF14187	DUF4310		Domain of unknown function (DUF4310)	Eberhardt R	re3	Jackhmmer:B0P5U5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 231 amino acids in length.	27.00	27.00	29.30	29.30	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.47	0.70	-4.83	9	318	2011-05-13 07:18:32	2011-05-13 08:18:32	1	2	315	0	37	122	2	207.80	80	95.54	CHANGED	ppp+sFWaADWoFPlhVulhuAulFAGTHMYhsYGlGAFNElAlVAMLcAGlssGsYGAAAAFGASFLFARILEGsLVGILDlGGSl.TGlGlGlPAlLLuuGhstslsNFsLSLlTGuVlGLlIGhlIIhlRKhTlsQusSTaGADlMMGAGNsoGRFLGPLIILSAhsASIPlGIGShlGAAlFYhacKPIAGGAILGAMlhGulFPl	..cpsKuFWYADWSFPIFVGLLSuGVFAGTHMYYLYGlGAFNEVAFVAMLKAGhDTGsYGAVAAFGASFLFARIIEGSLVGILDIGGAIQTGVGLGVPALLLGAGhlaPVuNFhASLlTGLVlGLAIGYIIILARKFTINQSsSTYGADVMMGAGNsSGRFLGPLIILSAhoASIPIGlGSLlGALLFYIWpKPITGGAILGAMILGuIFPl.........	0	4	9	23
+14030	PF14188	DUF4311		Domain of unknown function (DUF4311)	Eberhardt R	re3	Jackhmmer:B0P5U6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 260 amino acids in length.	27.00	27.00	98.70	98.40	23.00	22.70	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.23	0.70	-4.83	9	329	2011-05-13 07:36:43	2011-05-13 08:36:43	1	1	314	0	38	136	0	202.20	82	82.56	CHANGED	ARMFHAPssQuMGAFRTLGELNACpGDPhSHFSFGLGFhFNAWASsVGAGAhTQDVpHRIIPNWAAAsLLhKNKsVpETL+DPKKMuIuGAlIGslVVshLNsTAuuIPESLQslAscVLVPAANhLINsVMPIlFWLAAlDAGK+TGhWGTlhGGLupLIMGNAVPGlVLGILIGKGVD-SGWN+lTKsMhsslllLFllSGFFRGFDhpLl	......ARMFHAPTTQGMGAFRTLGELNSCEGDPASHFSFGLGFFFNAWASSVAAGuFTQDVDHRIIPNWuAAALhlKNRNVu-TLHDPKKMAIAsAlIGMlVVsFLNhTASuVPEALQVTAVKVLVPAANlLVNhVMPVIFWLAAIDAGK+SGFWATlFGGhAQLIMGNAVPGLVLGILIGKGVEESGWN+VTKlMMsAIVLLFVLSGFFRGFDhKMI.......................	0	4	9	24
+14031	PF14189	DUF4312		Domain of unknown function (DUF4312)	Eberhardt R	re3	Jackhmmer:B0P5U7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 99 and 118 amino acids in length.	27.00	27.00	60.20	59.90	18.70	16.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.53	0.72	-4.15	20	309	2011-05-13 07:57:18	2011-05-13 08:57:18	1	1	308	0	38	108	1	84.80	62	80.17	CHANGED	phspoVpVsGKGcoKpcAFAsALuplQ+pVl+ssspllLRIEPh-VpllcAcEpspsEKFLFFFhPRcRppYpVcL-loVsVThI	....phTTTVpVpGKG-sKs+AFAsALNcVQssVh+E.oshlLLRIEPpDVcIlQA+EsVppEtFLFFFL.RcR+oYuVEL-VTVsVTAI..	0	4	9	23
+14032	PF14190	DUF4313		Domain of unknown function (DUF4313)	Eberhardt R	re3	Jackhmmer:B0P650	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 171 amino acids in length.	27.00	27.00	28.00	34.50	22.30	19.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.20	0.72	-4.32	20	120	2011-05-13 08:28:26	2011-05-13 09:28:26	1	1	84	0	7	94	5	103.80	32	61.26	CHANGED	lpLpVssYhssss....LhItLhpp-...psphEsausLTVNLsshh.....spAFIsssss.c-hhpFlpcppLucsoGhptpSGaspYsthtFshc+LpcLDP-GhpcYtcphs	......hhlspYhsNst....LhlsLhs.c....tp.E.assLTVNLsshss.....sscuFlssNps..s-hhcFlpcNcLucso.....Ghpt+SGaspYshhhFslscLtchsPcshpchttt.s.....	0	2	7	7
+14033	PF14191	YodL		YodL-like	Eberhardt R	re3	Jackhmmer:B0P785	Family	The YodL-like protein family includes the B. subtilis YodL protein Swiss:O30472, which is functionally uncharacterised. This domain family is found in bacteria, and is approximately 100 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.	24.00	24.00	25.10	24.50	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.38	0.72	-3.53	50	285	2011-05-13 08:42:40	2011-05-13 09:42:40	1	22	147	0	33	244	34	101.40	33	14.67	CHANGED	tcsasIYQL+t..tscstsh+Fhsh-pLpppGh......pschpsYchVYsutlp........spsLEslap+FNhc+.P.tDacGHSLSlSDllhLppsGcsosaYVD.shGFpplstFh	.......................t.csauIYQlpt...spstsh+F.sh-tLpttsh......plctpsYclVYsusLs.........spsL.Ecl...appFNl..c+..P.tD........acG+SLSVSDlVslcp..sG.c..sosaY.l.D.ohGFpplstF..............	0	20	28	29
+14034	PF14192	DUF4314		Domain of unknown function (DUF4314)	Eberhardt R	re3	Jackhmmer:B0P797	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 56 and 93 amino acids in length.	24.00	24.00	24.30	24.40	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.42	0.72	-3.74	61	138	2011-05-13 08:50:07	2011-05-13 09:50:07	1	4	85	0	31	127	2	97.20	22	44.82	CHANGED	stGoRshLht...................hs.....cs.t.h.tusp..........................................usl.tVD....................Dhupl................p....................sh........hDs.GpuL............sll.Gc-hhphl	........................................ssRshhhh...................hs..........ss.t.ltpt.sh....................................................usl.sV-....t..hhssht....t..sttpl................p............................hh..h..st.hDs.Gpuh............tl..Gp.hhph.........................	0	22	28	31
+14035	PF14193	DUF4315		Domain of unknown function (DUF4315)	Eberhardt R	re3	Jackhmmer:B0P8U3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	27.00	27.00	27.20	27.20	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.83	0.72	-4.06	19	219	2011-05-13 09:28:17	2011-05-13 10:28:17	1	1	101	0	16	153	27	84.00	38	94.37	CHANGED	sKlcKlptEI-Ks+pKIsEhQu.......+L+ELEppKTEhENLEIVplVRuhsho.p-LsshLpth.........uGpssPtst.......ppc-ttcEc	.....sKl-+Icp-IcKs+...cKIsEhQp.......+L+pLEspKsEtENl-IVphVRuh+hoPppLsAhLpsh...................shtssPtsps.t....ppEcp....t..................................	0	11	16	16
+14036	PF14194	Cys_rich_VLP		Cysteine-rich VLP	Eberhardt R	re3	Jackhmmer:B0P8U5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. It contains 6 conserved cysteines and a conserved VLP sequence motif.	27.00	27.00	29.30	29.30	22.90	21.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.02	0.72	-4.23	20	192	2011-05-13 09:48:24	2011-05-13 10:48:24	1	3	84	0	20	140	9	54.90	55	41.26	CHANGED	TtpQ+++lptLl+phCsNY.Ds..GNCLhLD-G-spsCsQsIS.aSlhC+YFRpAVLPtD	.......tQp+psppLl+tpCCNYDs..GNClhLDDG.-sCsCsQoIS.aSlh..C+WFRtAVLPhD..	0	11	20	20
+14037	PF14195	DUF4316		Domain of unknown function (DUF4316)	Eberhardt R	re3	Jackhmmer:B0P8U6	Family	This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 56 and 95 amino acids in length.	25.00	25.00	25.20	25.20	24.40	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.70	0.72	-3.90	15	205	2011-05-13 10:04:25	2011-05-13 11:04:25	1	13	99	0	14	169	30	83.90	37	10.96	CHANGED	+pNPLKsAElohE...QNYNMlDGllNN....sPsh.....................................s--KPSlhD+LKpspp+pcu+c....................ccEp	......-NsLKsAEhshE...pNYNMIDGlINN.....tsPohs-lEtt.pt..................................................................tt.pttp.ccKsSlhcpL+stpcpppp.+p.......s..ppp.....p............................................................................	0	9	14	14
+14038	PF14196	ATC_hydrolase		L-2-amino-thiazoline-4-carboxylic acid hydrolase	Eberhardt R	re3	Jackhmmer:B0P9R4	Family	This family of enzymes catalyses the conversion of L-2-amino-delta2-thiazoline-4-carboxylic acid (L-ATC) to N-carbamoyl-L-cysteine [1]. It cleaves the carbon-sulphur bond in the ring structure of L-ATC to produce N-carbamoyl-L-cysteine [2].	25.50	25.50	25.60	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.26	0.71	-3.81	62	369	2011-05-13 10:27:15	2011-05-13 11:27:15	1	8	272	0	100	357	53	152.10	18	73.90	CHANGED	lt+cth.............................hpAthhthlhcpht.cchup..cpuppll.pcAlpphut....ttGps.httph.t.....ssshp.sFts.hhhshtpssshc...chhc..........tscschthchpcCshscha+chGh..pphthhhCch....Dtshspuas....slc.hp+spTlscGsspCcFpa	............................................................................tththht.......................A.hhh...hhctht..cphs....ppspthh...tculp.t.huh.........ptucp..hstt..t...........pshp..patp...ht...htht..t..s..ts.hc.....chhp..........ssc..p..p..hthchpcCshschh+chGh....tcht.hhCph....Dt.shhpsht.........slp.h.p.R....s....pT.lu.p.G.sspC-apa...................................	0	56	76	86
+14039	PF14197	Cep57_CLD_2		Centrosome localisation domain of PPC89 	Wood V, Coggill P	pcc	Jackhmmer:Q10218	Family	The N-terminal region of the fission yeast spindle pole body protein PPC89 has low similarity to the human Cep57 protein. The CLD or centrosome localisation domain of Cep57 and PPC89 is found at the N-terminus. This region localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, Pfam:PF06657, is the microtubule-binding region of Cep57 and PPC89.	27.00	27.00	27.60	27.60	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.10	0.72	-4.03	24	78	2011-05-13 10:39:40	2011-05-13 11:39:40	1	5	64	0	67	80	0	72.30	30	8.30	CHANGED	p+L-upp.sL..ps+L.DhhpR+sphp-....tthKpLsp...ERDtshppLus.Ah.csp-L+sE.-sLcpE...........Lcpph.tp	....cLEsphtsL..Qs+LDphsR+sssp-....tp.cpLsp...ERDpshppLs..AhtcspcL+pEh-sLppE...........Lcphp......................	0	13	34	55
+14040	PF14198	TnpV		Transposon-encoded protein TnpV	Eberhardt R	re3	Jackhmmer:B0PBU6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 114 and 125 amino acids in length.	27.00	27.00	27.10	28.20	26.10	26.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.24	0.72	-4.17	56	477	2011-05-13 13:11:50	2011-05-13 14:11:50	1	2	167	0	34	365	68	101.40	42	88.22	CHANGED	sYphhGD.Y...........alPsLp..lsc-pc....sl............G+YGch++pYL+Ea+sshYspLllsGcLhp+Ls-l-cpAp-ph-hllpQhtcppGlTEpLKspspMcWVppMNsl+spAEEIVhpEll	....................................pYh..GD.Y...........hlPsLplsppcp....sl..............GtaGph+ppYL+ca.+.shYspLlhoGc.LhsaLs-lscpAp-Rh-tllcpMtptpGl...T.EpLKspstMcWVtphNsI+spAEEIVhpElI...........	0	17	30	33
+14041	PF14199	DUF4317		Domain of unknown function (DUF4317)	Eberhardt R	re3	Jackhmmer:B0PBX6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 225 and 451 amino acids in length. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	36.80	27.90	21.50	26.40	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.04	0.70	-5.67	45	203	2011-05-13 13:17:54	2011-05-13 14:17:54	1	2	155	0	33	197	9	334.90	34	95.75	CHANGED	M...N......KK-lsEI.+KpF+.-s..ssIo+lsGCYVst-.+-lhpphp-sFlsLp-EEh.KYLpIFKKsLSGolGcNLl-lcFsh..................cp-tpuupQphLhpL+pSpLcD-..thl-cFYc+lIcsYsY.ssNalIllh+ssYDlPsKssDs.pph.DsS-EVY..caILCoICPVpLsKsuLsYptp-NphcsRh...pDWlVpsPptGFLFPAFsDRusDlaslLYYo+csc-.c.cFlEplLGsshshTAt-QK-sFpsIlc-slG--sch..-slpslaEpLschIE-pc.t.....psEP.htLspp-lcclLppSGVs--ph-ph-psac-shss.......................csshhAsNll...soKplcl.........................................................................................................................................cT.DlslpVsPc+schVcophID.G++CLlItl..s-psplNGls	.....MNKK-lhEl.++..paphsp...ssho+lsGCYVct-.pphhtphppsFhpLsp-Eh.K..YlclhKKsLoGslspNLhchpFsh..................pppttsup.....QphLhpL+pSpLc--....tLh-pFYcpll.-sY..pa.s..........tsahIllhHstYDlPsKssDs.tph.-.tS-EVY..callCulCPVpls+.uLta..tppphtsch....shhlphPt.GFlFPuFpDRssDlpplhYYoppspp.p.phh-phLsst....oAttpKtsFptllpcshupc.ph..chhhpl.-plsph..l-ppp.......p.-s..hLs.pplpplLtpuGl.p..htph-ptatp.h.t.......................p...hApslh...ss+phph................................................................................................................................ps.sl.lplpPpc.h..lcp.hlc.GpchllI.l..s-psplsGh........................	0	20	32	33
+14042	PF14200	RicinB_lectin_2		Ricin-type beta-trefoil lectin domain-like	Coggill P	pcc	Jackhmmer:Q8X123	Domain	\N	35.10	35.10	35.10	35.10	35.00	35.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.72	0.72	-3.66	49	1501	2012-10-02 19:42:32	2011-05-13 14:20:14	1	251	412	51	644	2662	47	100.70	22	25.03	CHANGED	ssQpWphp....h....s..........ss.....t.......aplh...ss..s....o....uphLssss.ss.tpustltth.s.s.......sssppWplps.ss..s..G..t.apl.hsh...ss.s....h.sLc.lts.s.s.ss......susslhhaph...ts.ss...sQpWphp	..........................................t.............................su........h...........a.p.lh...st..t.....o.....GpsL...sl..ss..ss....s..s...sGs.p.l...tta.ssss......sssQpWpl.....ss....su..............s....G.....h...apl.tst........so.s.......................hsLD...lts..u..u..ss........sGs.s..lh.as......ss...ss.....sQpWph......................................	0	285	489	608
+14043	PF14201	DUF4318		Domain of unknown function (DUF4318)	Eberhardt R	re3	Jackhmmer:B0PDG9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a single completely conserved residue F that may be functionally important.	27.00	27.00	27.30	27.50	25.30	24.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.37	0.72	-4.15	13	131	2011-05-13 13:28:57	2011-05-13 14:28:57	1	1	104	0	4	69	0	70.70	52	79.81	CHANGED	+KuFhI-L-DuhpYPoscsICpAlEpYstcsppslcFlu+scPl.hhl-sshYElcl...phuRGsYa.lpC+El	..........pKSFFIELDDuLTYPSuEs........IsoAIEpYssEsNEpL+FESKsKPIhFYL-ss.hYcsEl...+MARG.GYY.ISCpEV...........	0	1	3	3
+14044	PF14202	TnpW		Transposon-encoded protein TnpW	Eberhardt R	re3	Jackhmmer:Q9L782	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 54 and 75 amino acids in length. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	26.90	26.30	24.00	23.60	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.44	0.72	-4.36	31	347	2011-05-13 13:45:03	2011-05-13 14:45:03	1	2	153	0	30	225	25	36.90	36	58.15	CHANGED	sshp++IGpTTYhVplpFscsupEThpDKlpRllcs-	.....hhpp+IGposahVplaFscsus-ThpDKlt+llctE.........	0	16	28	28
+14045	PF14203	DUF4319		Domain of unknown function (DUF4319)	Eberhardt R	re3	Jackhmmer:B0PDI8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There are two completely conserved residues (E and K) that may be functionally important.	27.00	27.00	27.30	35.90	22.70	25.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.85	0.72	-4.43	27	181	2011-05-13 14:14:01	2011-05-13 15:14:01	1	1	81	1	7	129	22	64.30	37	90.68	CHANGED	pFTlEEpNLhslYps.uoRpphIcslpth.hsah...Ds-.....MtpLsppslsKLpshoDsEaspLplhss	.......pFThEEhNLhslYss.......uoRpslI-slpth.hs..h....-s-......hRcLsspslsKLpuMTDu-FucLplhs..............	0	4	7	7
+14046	PF14204	Ribosomal_L18_c		Ribosomal L18 C-terminal region	Coggill P	pcc	Jackhmmer:Q9FL18	Domain	This domain is the C-terminal end of ribosomal L18/L5 proteins.	23.00	23.00	23.10	24.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.23	0.72	-3.43	90	635	2011-05-13 14:31:27	2011-05-13 15:31:27	1	8	464	10	360	612	6	87.50	41	31.06	CHANGED	AEshRcaIaGtHVA-YMcpLpE-D-EpY+pQFSpYIK..pGlsADslEchYpcAHtAIR......tDPsh.ccpp...........pcph.hpp....K+apppKLThcpR+pRVtpK	..........AEshRcaIhGtHVA-YMctLtE-...D..E......EtY+cQFSpYIc...pulss-sl.E-hYccAHsAIR......ts.Psh.ctp.......................pc.p.h...pp..........K+apt.Klohtp++s+ltt.........................................................	0	121	192	283
+14047	PF14205	Cys_rich_KTR		Cysteine-rich KTR	Eberhardt R	re3	Jackhmmer:B0PDJ5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length. There are 4 conserved cysteines and a conserved KTR sequence motif.	24.50	24.50	25.00	24.90	24.00	23.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.82	0.72	-4.51	23	165	2011-05-13 14:39:52	2011-05-13 15:39:52	1	3	119	0	10	88	7	52.00	56	84.28	CHANGED	pscWlLCPlCGNKTRsKIRcDTlLcNFPLYCPKCKQEsLIsVcpLpIoVIKEP...DA	.......t.WlhCPlCGsKTRlKIRcDT.L+NFPLaC..PKC+pEsLIclc.phcloVIpEPDA.........	0	7	9	9
+14048	PF14206	Cys_rich_CPCC		Cysteine-rich CPCC	Eberhardt R	re3	Jackhmmer:B0PDW3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 68 and 104 amino acids in length. There are six conserved cysteines and a conserved CPCC sequence motif.	24.50	24.50	24.90	25.00	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.02	0.72	-4.42	25	243	2011-05-13 14:50:38	2011-05-13 15:50:38	1	7	210	0	43	194	2	68.40	37	67.44	CHANGED	patCPCCGYhTlspcsst...a-ICslCFWEDDslphpss-ht.uGuN.clSLp-ApcNFtcaGAC-pchhph.VRpPts.--h	................hpCPCCGhhThp..s..........a-ICslCaWEsDsh............t.tps........s.................h........t..uGsN.phoLpcA+pNahthts...................h..................................	0	15	33	40
+14049	PF14207	DpnD-PcfM		DpnD/PcfM-like protein	Eberhardt R	re3	Jackhmmer:B0PE77	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 57 and 153 amino acids in length. There are two completely conserved residues (E and A) that may be functionally important.	25.00	25.00	26.80	26.10	24.00	23.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.12	0.72	-4.21	18	267	2011-05-13 15:01:36	2011-05-13 16:01:36	1	2	239	0	12	86	7	48.60	53	41.50	CHANGED	K....YcVcIsETLp+hVpVcAcoc--AhphspchYpsp-..IVLss-DFps.s-	.....KKYsVEIsETLSRlVSlEAE.s.D.EAccLVc-pYpspE..IVLDADDFpsh-................	0	7	10	11
+14050	PF14208	DUF4320		Domain of unknown function (DUF4320)	Eberhardt R	re3	Jackhmmer:B0PFN6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 120 and 131 amino acids in length. There are two completely conserved residues (G and Y) that may be functionally important.	25.00	25.00	25.10	25.20	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.13	0.71	-4.14	20	145	2011-05-16 07:46:53	2011-05-16 08:46:53	1	1	99	0	15	97	0	116.10	30	89.67	CHANGED	llLsshllIALuVclhPlalsKppLDsFAsELVRpAEluGplu.......sETsp+ttsLcE+TGlsPp..lpWS............psG+IQLNp-lsVTlThchclGlFu....sFu...SFPlTlpApAoG+SEVYaK	...hlhhulllIsLhspsshhhhph.chcsaAsphlc.AEpsGGhs.......scssshltslp.c+.httpsh....hsWc.-..........ppG+lpaNpslshplpuchc.hhlFt....shs...shclslpAptsGhuplYa+................	0	11	15	15
+14051	PF14209	DUF4321		Domain of unknown function (DUF4321)	Eberhardt R	re3	Jackhmmer:B0PGC7	Family	This family of proteins is functionally uncharacterised.  It is found in bacteria, and is approximately 50 amino acids in length.	27.00	27.00	27.50	27.50	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.15	0.72	-4.27	43	156	2011-05-16 08:00:46	2011-05-16 09:00:46	1	1	155	0	48	130	27	48.70	31	56.63	CHANGED	hlsaLshshs..lGhsss......slDLtllplohG.lslclNlhoIlGlllAlhlY	............lsaLshshs..lGhsssh.....sLDLtllploFG.lslclslhoIlGlllAlhlY.....	0	29	43	46
+14052	PF14210	DUF4322		Domain of unknown function (DUF4322)	Eberhardt R	re3	Jackhmmer:D2PCT9	Family	This presumed domain is functionally uncharacterised. This domain family is found in archaea, and is approximately 60 amino acids in length. There is a conserved QTV sequence motif.	27.00	27.00	28.20	33.90	20.30	22.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.13	0.72	-4.50	7	162	2011-05-16 09:56:38	2011-05-16 10:56:38	1	1	13	0	20	159	0	58.40	72	22.23	CHANGED	hTPsh.pp.shpQIsaKLLShlsFpGRKuEEVpKsLVSAuLhpDSVENKuptaslSPQTVRNYsEE	...lh..LPHQNNlQQIGYKLLSMLNFpG+KuEEVA+TLISACLWNDSVEsKSRAYsVSPQTVRNYVEc............	0	18	18	20
+14055	PF14213	DUF4325		Domain of unknown function (DUF4325)	Eberhardt R	re3	Jackhmmer:C4FKE5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length.	27.00	27.00	27.10	27.40	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.24	0.72	-4.33	60	205	2011-05-17 10:57:51	2011-05-17 11:57:51	1	5	197	0	61	187	21	71.20	22	43.03	CHANGED	ppupclhpp.lpphlptst...VhlDFpul.phhspuFhsphhuplhtphs......tthcpplphhshscsspthlp+.lhsp	................pupplhpp..l.....t....phhpttp....lh.lDFcGl.stlusuFhcEsFushhp.c..hs.........t.hcpplphh..shspphpthlth.h................................	0	19	43	52
+14056	PF14214	Helitron_like_N		Helitron helicase-like domain at N-terminus	Coggill P	pcc	Jackhmmer:Q9S9S3	Family	This family is found in Helitrons, recently recognised eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.	28.70	28.70	28.80	28.80	28.40	28.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.11	0.71	-4.56	42	666	2011-05-17 12:28:46	2011-05-17 13:28:46	1	43	74	0	525	652	26	155.40	26	14.84	CHANGED	Ya..sa+l..phRpsphshhhp...st+LhpQa..hVDtaspl-ps..RLpalp..p..pQpplRschhpulpDA............hppups.cs...sphGc+ll.LPuSasG.u.RahhppYpDuh.....Als+taGhPclFlTFTs.Ns+WsEItct...............lt........sppspD.....................RPDllsRVF+hKlcpLhc-lhpp...phFGp.shs.hhaslEFQKRG.LPHsHlLla	...........................................................................................................h...h.....hp.....h.pt....phthht..........pp.tph.....pt.................h.tt..l.pt...................................ht.tttt..ph......p.t...h...pphh..hstshhG.....s...........phhhpph..-sh.....Ahspp....hGt..P.slFl.Thos.s....s....p.Wt-.l...hph...................lt...........tp.psp..D...................................cPshssRh..Fph+......hpthhp.lhtt...................thh.Gp...l.t.hhhhhEaQtRG.sHhHhll..........................................	0	194	351	473
+14057	PF14215	bHLH-MYC_N		bHLH-MYC and R2R3-MYB transcription factors N-terminal	Coggill P	pcc	Jackhmmer:A8MSG2	Family	This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, Pfam:PF00010. Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species (DOI:10.1007/s11295-009-0232-y).	22.20	22.20	22.20	23.20	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.04	0.71	-4.04	95	661	2011-05-17 12:29:08	2011-05-17 13:29:08	1	12	127	0	262	681	0	164.70	31	30.79	CHANGED	Lp....ppLpsllp.......stpWsYAlFWp.s..........................................lLsWuDGaap.us.p.t.t......................t.t.t+pp.hpch.p.hs.........................................hth...-lsssEhaahssh.asa.....GpG...........lsG+shssupphWlssspp........h..ssphhs.........R.uh.Ap.tuh...p..............Tllsl..Ps..s.GVlELGSochlhEshshlppl+shF	.....................................................................................pptLthhsp.......s.p...WoYulFWphsspp...........................................................hLh.WsDGaas.Gshcscpt...........t...................ththpRsctLc-Lht.h..s...............................t.sssshss--ls-sEha..alhshsasF.........GpG.....................LPG+shusspplWlssspp................................s....ssphht...........R.uhhAp..tuh......................TlVslPh..hsG..VlELGoTchl.E-.shlppl+shF.................................	0	48	172	220
+14058	PF14216	DUF4326		Domain of unknown function (DUF4326)	Eberhardt R	re3	Jackhmmer:A8ZQW0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.	25.00	25.00	27.30	25.30	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.28	0.72	-3.41	43	174	2011-05-17 12:59:55	2011-05-17 13:59:55	1	3	156	0	61	180	43	92.70	29	68.43	CHANGED	splspp.+ttphss...........t.h.YlGR..........sop.....W.GNPFshsp.................sssR........ppslcca+pal.................tppshhhptlt.cL.......+G.+.sLuCaCs......P.........CHuDVLt-l	.......................................p..ht.ths...........h..al.GR..............soh.....a.GNPFthtt..............................................ttsR.........ppslcta+palh..................................tssphhhptlt..pL.......c.G...+..pLuCa.Ct..................P.ts.............CHuDVlhc................	0	19	47	56
+14059	PF14217	DUF4327		Domain of unknown function (DUF4327)	Eberhardt R	re3	Jackhmmer:B0BYV4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	75.80	75.60	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.14	0.72	-4.16	39	113	2011-05-17 13:09:37	2011-05-17 14:09:37	1	1	41	0	44	101	0	67.60	45	88.51	CHANGED	paol-hIp-EARpLVcpGllpRpQPIasLspalPuREWshlEpELEcp-FLLRDpIsDLlu.sEsWc..-D	...YolchIp-Es+pLVcpGllsRpQPIYsLCpaIPuREWstlEpELEcp-FLLRDpIuDLlu.sEsW-pD...	0	5	32	44
+14060	PF14218	COP23		Circadian oscillating protein COP23	Eberhardt R	re3	Jackhmmer:B0C7I3	Family	This family includes the circadian oscillating protein COP23 from Cyanothece sp. (strain PCC 8801), Swiss:Q54702. The levels of this peripheral membrane protein display a circadian oscillation [1].	27.00	27.00	30.90	30.40	17.60	16.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-11.05	0.71	-4.60	63	131	2011-05-17 13:43:54	2011-05-17 14:43:54	1	6	38	0	42	156	4	146.20	22	65.35	CHANGED	pFhCt.........................................hssp............sTlstpsp..uph...slltWs....s.h.suuaoPppRCppVosRhpphtss....h.................th.hlps..Ghh.NspsVlCsssptss.sC.....pslLhTL..pssss.....sppsLpplhs.......t..p.................................ttstp......hlshsshLsss	.................................................pFhCt........................................tsp.......sTlshpsp....uph...PllhWs....sth.susaoPppRCppVSsRhpphhps....h...............................thphlps..Gph.Nsp.sVICsssptss...sC...pslLhTL..pssss.....Pppslpplhshht....t....s....................................psstt.......lphp.hlt..t.....................................	0	1	33	42
+14061	PF14219	DUF4328		Domain of unknown function (DUF4328)	Eberhardt R	re3	Jackhmmer:B0C5R9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 218 and 342 amino acids in length.	24.80	24.80	25.30	25.00	23.40	24.10	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.49	0.71	-4.96	51	224	2011-05-17 14:05:06	2011-05-17 15:05:06	1	7	194	0	73	216	1	164.40	23	55.87	CHANGED	lltphpssh.............ht.sthstu-thssh.....suhsthlhhlsssllhlhWlhRs+tsApsht............ts.chsssh....slsuahlPlsNLhhPhphhtElapuotths.............................t.sthlhlW...W.....hhWl.................lutslshhshshs.....htsssptls..............tsshhslhsslhsls..sulhslhllcplsp..hp	..............................h..............h...hhttushhssh.....su.lsshhshlsshllhlhWLhttRssAhhhts...........hs.Rhust..hhuGhhlPhlNLhhshhhlhElhtspsphs.............................phpthlssW....W.....hsWl.................lussl.s.h..hs.hshp......hss..sspshs...................ssshh...hlluhlhuss..usshshhlhcthpp.....................................	0	29	57	68
+14062	PF14220	DUF4329		Domain of unknown function (DUF4329)	Eberhardt R	re3	Jackhmmer:B0C699	Family	This domain is functionally uncharacterised.  It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with Pfam:PF05593 and Pfam:PF03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.	27.00	27.00	30.70	30.30	26.70	25.90	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.62	0.71	-4.17	20	415	2011-05-17 14:18:05	2011-05-17 15:18:05	1	16	244	0	18	432	7	126.10	48	15.32	CHANGED	tpshApshLpplpscSIspspEYsGhIsp..sssGchhuo..psppG..........ppsushsths.s..shphVAuYHTHGuasps...........YssEl.SstDlpus........tpptlsGYluTPuGRlahlc.psppsp.phsshusl	.........................I.DDhuh.ALshhNucSIsEsKEYuGLICK......ppG.cYF.so...sP.su.........s-pcus..hNhtCPpGoE+VusYHTHGh.Scs.............sYss..FSuKDhp.sh............uhspp.hu.Y...LGTPsssahthss+u+t.s.........sp............	0	8	12	15
+14063	PF14221	DUF4330		Domain of unknown function (DUF4330)	Eberhardt R	re3	Jackhmmer:B0C6A2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 165 and 177 amino acids in length. There is a single completely conserved residue G that may be functionally important.	27.00	27.00	30.40	28.90	23.30	21.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.97	0.71	-4.40	43	119	2011-05-17 14:26:20	2011-05-17 15:26:20	1	2	109	0	50	119	32	159.90	25	88.80	CHANGED	M..t...llDspG+LFG+lSllDlsAslllLhslsGlhhhPtt..osss...Aph...ssspslpV..sl.lhsltsssPpshhtp.hpt.......spcssllIRNQPh......GplpltsVp.ls+plssspPDGsVhshsD...Pp.t..hphDhhhTLcGpupho.ssGs...VlGspclKIGsslELEGpsYphsGoVh...slcl	..................................M.llDpcG+LFGplsllDlhshllllhs.lsGlhhhstp.ssss.....Ap....ssspslcl..shhlhslpstsspthhtp.hpt.......sspsshhh+spshG....plpslp.h..spsh.hsspsDGp.Vh.thsc...P.....hthDhhlTlcupupho..ssGs.....llG.spcl+lGps.lpl-stsaphsusVhslp........................	0	17	36	47
+14064	PF14222	MOR2-PAG1_N		Cell morphogenesis N-terminal	Coggill P	pcc	Jackhmmer:Q9LFV8	Family	This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.	20.30	20.30	20.50	21.50	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.96	0.70	-5.83	35	407	2011-05-17 14:28:14	2011-05-17 15:28:14	1	28	236	0	259	372	3	456.00	35	21.39	CHANGED	u-..R+uhlSl...YllCRVLIEIhpQss.hp.slsp-htc+LEsllFsQL..KssD.s.....p.ls.sSsl+huNWslaApLLGhh..SchpF..sSVocRFls-Lcc........hp.p......pps......cs-sphthLIhGMRaL+l+saP.Esa-cSs-Fhpulu+hFspup.pc..lKpAaspllpplLLPlAussss-....lspP...pWs-slstlhschsphhs..K.s+HWss..u.FPLtssLLClSsp-hFhspWh....thlpsL.s+lKD+..spR..sluLpulsRLlWsYL..apss-ossssh++L-plhchhl..Psu+.........+..shlssD..shh-PLlpllphIuac+.Dash+pIIaPLlssshhtss.....lcplpPE+hllGIRuaLsIhsshppspt......................................t.h.tsppc......hls......s...ssth.spslppaa.chschlsc.IhllhDsshGupshh....s.....cphst.p..ssht...................h.hthpsD.ph...o..sp....+pth...-L.h+sslpAlPRCL..us..pIPa..ssLIslLspsssHlpssIupouupuL+uluppp..tsppVhhGFA+FlFs.FD-+asoh.s.th.Ls..cl-ssL+L.YlELLplWl	......................................-R+shs..aIhshVLlEllpQhs..hp.sh.c.....th......hpcl.slsFpph..Kht-..s.........s.sush+.h.hslaApllGhhup.t+.......F.uVpc+Fhs-Lcchp.p...........p.s......s.tphh.LlhGM+ah+l+hhP..EtaEtShpFhp.phuphFhcs...pc.tlKpAhstlhsplLlPlAuss.psE.............lshP......phtphlp.lh.pshph.s..+...p................+H.....................hs.........h..aP.LhssL.....LClSppphF..hs.pWh...................thlppLh.........K.................D......ph..p..tluLpulhRLlWsYh..hhps-o.s.....sT..p..+L.plhphlh.....Ppsp...................+..shlspD...h.ls.hlpllphIu.c+.D..ash+pllhsLlsssh.hp....................................h.plpPE+hsIGlRuaLsIhsslppt-t.ss...p...............................................................sssshpspph..pphls...........p.ptsps.uhp.Yasphpchlsp.IhhhhDpphGp.hhh.....s............ph..h..s..p...............................................c.cD..hh...o.....sp.....Ksph..-L.F+osltAlPRhl.........sc.........shsh.................ppLl-lLs+..h.olHh-pplpt.u.poLpslhhph..atpsVhhGFspFlhc.hsDha..sh.....................l-ssl+hhlpLlp.Wh....................................................	1	76	133	204
+14065	PF14223	UBN2		gag-polypeptide of LTR copia-type	Coggill P	pcc	Jackhmmer:A5B9L3	Family	This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.43	0.71	-10.24	0.71	-4.31	123	1538	2012-10-02 13:37:57	2011-05-17 15:37:42	1	195	75	0	589	2426	5	103.70	21	14.09	CHANGED	coAKchW-sLcpha.Gss..+s+tuclppLcpca-plcM+-sEolc-ahs+lpslssclpslGp.phs-pclVcKlLpoLP.p+appllsul-pt..hDhpp.hol--lhupLpstEp+h.ppppsp	...................................................................stthWphlpt.atss..p..p......s...ph..lppph..t.thp........h.p.ss....c.s.l...p...-aht..+hp...sl.ss...p.l.....p.............s.l.....G.............p....s....h......s.........-p.........cl.lp..+..........lLp.....u.....L....s..pc..ap..hhss...lppp...sht.....ohp-lhspLh.shE.ph......t...................................................	0	132	305	345
+14066	PF14224	DUF4331		Domain of unknown function (DUF4331)	Eberhardt R	re3	Jackhmmer:B0C6N1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 526 amino acids in length. There is a conserved FPY sequence motif.	27.00	27.00	32.60	32.40	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.61	0.70	-5.29	47	155	2011-05-17 14:40:04	2011-05-17 15:40:04	1	2	121	0	70	177	49	349.20	25	90.04	CHANGED	SoHc-uP....htttsphDhTDhYhFpS.............tcsstlsllhNh.Php.......sssshhthsssuhYcl+l...........DscG......-..uht......D.lsapFpFss...............................................................................h..sshGptsh.........shtthtst.l.t...h...s......shpsFsGpRpDsFhhs....l.thapl.........................th...t.s.sshtsh.NVpolulclPtstls.t..........t.slGsWsossh.........................h.sGsasQlsRlGpPhlNcl..h...hsh...t.-.KDpaNsspPspD...upahshhtsshhstlhth...h..........................hsRsDllsshlsshst..........................h..s-hLclssuhPss........................................uuaPNGRphs.......DDVlDlsLphlhG.h.....................................t.hshs..cssshsss..shhssFPYLusP	...................................................SsHh-uP........hst...tsphD.oDhYsFpu.............tpsstsshlhNh..Pht.......sss.sh...hshs.sshYcl+I............DssG...D.uht.................D.lsapapFps...s...............................................h.p.ht...........................h.hs.sthGttshs..............shtth.tst.lht....hss..........shpsFsG.tpDsFhhs...htthhclht..............................h..sh...t.s.sshtsh.NVtolslclPpshlstt.................tsslusWsosph........................................sGsahQlsRlGtPhlNpl..h.hs.........t.s.KDtaNsstPtpD...spahphhhps...hshhht...hh...........................................................scschlshhhtsh.t..............................s-hLplssuhsss............................................suaP.NGRp.s.......DDVlDltLphlhG...................................s.....t.shh..sssshsst...h....ssFPYLs.P............................	0	19	44	65
+14067	PF14225	MOR2-PAG1_C		Cell morphogenesis C-terminal	Coggill P	pcc	Jackhmmer:Q9LFV8	Family	This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.	25.00	25.00	25.50	25.50	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.63	0.70	-4.64	38	388	2011-05-17 14:50:41	2011-05-17 15:50:41	1	28	236	0	230	364	0	247.40	32	10.74	CHANGED	cLltaPQLFWsssACLsolaEpEFlEuLphLs+hLsKlDLcsssshphLhsshPsp...........................Wp...GsF-GLQsLlhKGL+SSsoh-hTLclLs+Lshlsssplluss.po.RLlh.sllAsLPphLpph-pss..............pphhpsAptLuplA...cspshssLucllsuaucs+a.+opcDFlsphlshlpstaFPchpspslsaLlGLLpNshsWh+lpohplLpsllstlDhc....ps....hGs....D....LIuPLLRLLpT-hs.pALcVL.-plhshSGu.hhsc	...................t...hhsplFWsssuhLcSs...a...EhEal.uLcLLs+lLs+.....ls.Lcc....s....pspppLtphpsph.......................................................h....ssFsG.LQpLllKGh.....pSss..oh-hTlplLspLssl..spp.sll......ssu.......p.......s..t.....h.h.sllshLPphlpph-sss...................................................phsp..psA.pplAp.ls.............cstphs...sLAchhshYupppa.+sspsalshlsphL+.-sahschshphlsa.LhpLL.pp..uhs...hp.plLpllhslLsh....hDhp.............ps.............hss-.......l.lpsl.h+hl.posahtcALplL.chllohSuo.h..h.................................................................................	0	68	115	177
+14068	PF14226	DIOX_N		non-haem dioxygenase in morphine synthesis N-terminal	Coggill P	pcc	Jackhmmer:Q94JV6	Family	This is the highly conserved N-terminal region of proteins with 2-oxoglutarate/Fe(II)-dependent dioxygenase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.52	0.71	-3.55	783	5634	2011-05-17 14:57:58	2011-05-17 15:57:58	1	32	1392	66	2627	5670	1247	113.90	22	34.09	CHANGED	lPlIDlu.............s.....ss......c......p...ph.....h.p.p...ltpAspchGF.F....l...sNH...G...ls..p.......p.llpchhp.huccF.F.s.LPh-...c.Ktc.h.....tp.....s....s......th...pG...Ys.sh...htpph..ps.................phDa.cEt.h.phtt.p..........s.........p............................h.sh...WPsp	....................................lPllDls........................ts...tp.......p..tph....hpp...ltcAsp..p..hG..F.F.............l..............s..N..H......G...l....s..t........................p...l...l...c.ch.hp.......hs..ccF.F...s.L...P...h-...p..Ktch.........tp.....s.....s.................th..pG...Ys..s..h...h.t.p.p.h.ps................................th-a.c-h.h..t.h.th................................................................................................................................................	0	523	1614	2211
+14069	PF14227	UBN2_2		gag-polypeptide of LTR copia-type	Coggill P	pcc	Jackhmmer:Q1PE19	Family	This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.25	0.71	-4.55	97	1112	2012-10-02 13:37:57	2011-05-17 16:31:27	1	127	81	0	605	2057	3	105.80	19	15.57	CHANGED	ppoutplWppLcphahspshss+lhl...hp+lhsh...+Mp-sps.lp...palscFppllscLpsl.slpls-E...spshhlLsSLP.ss..acphhss...lh.st..splohcpltstlhs...c-hphppppppsps	.........................................................pstphWptLpt.h...att....p.s.....h...s...s...c...hhl.....hcphhsh........+ht.-.......s.......ps..lh.......palpch.p.ph...sp.cL....p....s....h....p........h....t....l...s.-c...........h.s.hhlls...sLP..ss........ac.shhts....l..hp...t......p.p.h...shpt.lhstl..........c-.thttt.....st.............................................	0	306	380	445
+14070	PF14228	MOR2-PAG1_mid		Cell morphogenesis central region	Coggill P	pcc	Jackhmmer:Q9LFV8	Family	This family is the conserved central region of proteins that are involved in cell morphogenesis.	27.00	10.00	27.10	10.00	26.60	9.90	hmmbuild  -o /dev/null HMM SEED	1120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.43	0.70	-14.01	0.70	-6.99	3	1087	2011-05-17 15:34:39	2011-05-17 16:34:39	1	28	226	0	651	1024	4	217.20	9	27.26	CHANGED	tEuSEFRASEMDAVGLIFLSSlDVQIR+TALELLRCVRAL+NDIRDYStpEphDspLKs-sEPIFIIDVlEENGEDIVQSCYWDoGRPYDLRREhDslPlDlTLQSIL.ESuDKuRWARCLSELV+YAAELCPSSVQ-AR.....LEVIpRLApITPsELGGKApQSQDTDoKLDQWLlYAMFACSCPPDSRE-uuLRAARDLaHLVFPSLKSGSEuatLAAThALGHSHLEVCEIMFGELTSFlEEVSSETEuKPKWK......SQK..t.RREDLRVHVANIYRhVAENIWPGMLoRKPlLRLHFLKFIEETsRQILsuPSENFQEIQPLRYALASVLRSLAPEFVDAKSERFDLRsRKRLFDLLLSWCDDoGSTWGQDGsSDYRREVERYKASQHsRSKDSlDKLoFDKEluEQVEAIQWASMNAMASLLYGPCFDDNARKMSGRVISWINSLFhEPAPRAPFGYSPADPRTPS.YSKa..TG..EGsRGuuGRDKQRGSHLRVLLAKoALKNLLQTNLDLFPACIDQCYSSDuuIADGYFSVLAEVYMRQEIPKCEIQRLLSLILYKVVDQoRQIRDDALQMLETLSlREWAEDGuEGuG+YRAAVVGNLPDSYQQFQYKLSuKLAKDHPELSEtLCEEIMQRQLDAVDIIAQHQVLTCMAPWIENLNFV+LKESGWSERLLKSLYYVTWRHGDQFPDEIEKLWSTVASKsRNIlPVLNFLITKGIEDCDSNASAEISGAFATYFSVAKRVSLYLARICPQQTIDHLVCELAQRMLEDssEPVR.ussKsDTSuNsVLEFSQGPssS.QlAolVDSQPHMSPLLVRGSLDGsIRNVSGNLSWRTAAVTGRSVSGPLSPMPPElsIlNVTTGRSGQLlPA...LMNMSGPLMGVRSSTGSLRSRHVSRDSGDYaLDTPNSuDDILHuG.sGsHGlNApELQSALQGHpQHhLSRADIALILLAEIAYENDEDFREHLPLLFHVTFVSMDSSEDIVLEHCQcLLVNLLYSLAGRHLELYEV.EsSDuENKQQVVSLIKYVQSKRGSMMWENEDPTLVRTELPSAALLSALVQSMVDAIFFQGDLRETWGuEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNPVPAVLG	........................................................................................................................................................s.tts...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tttt......................................................................................................................................................................................................................................................................................	0	151	278	466
+14071	PF14229	DUF4332		Domain of unknown function (DUF4332)	Eberhardt R, Bateman A	re3	Jackhmmer:B0C7H1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 134 and 356 amino acids in length. This domain contains helix-hairpin-helix motifs.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.12	0.71	-4.15	49	244	2012-10-03 02:11:09	2011-05-18 08:15:57	1	15	232	0	88	272	276	105.00	25	30.05	CHANGED	.GlsptptppL.ppsGIpospsLLptucs.tuRhtLApphtlstpplh+htshADLs.Rl.uluhpausLL.pAGlsoVspLApps.sppLpppltclptppphs+ph.....Psls.VppWIppA+pl	..........................................................h..t.sl.p..th.t.t....tp..h...tt..ht.t.l.th..t.s.phh.ph.GluppastlLpcAGlsolp-L.sp.ps.sppLpppltclNcph.clttph.....PolpplppWIppAp..........................	0	31	58	79
+14072	PF14230	DUF4333		Domain of unknown function (DUF4333)	Eberhardt R	re3	Jackhmmer:B0C9G5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.	27.00	27.00	27.80	27.30	24.10	25.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.65	0.72	-4.02	37	334	2011-05-18 08:13:58	2011-05-18 09:13:58	1	5	143	0	89	229	0	79.00	32	49.87	CHANGED	sssssusuhhhss........slDtsplppslpphLs....sshGhpsss.VsCP..ss.cscsGsohpCs.hs..lsGpshpVsVTlpss.DG	.......................h..h.hhhuh.hss....hs.p......slDpspltstlpphLs....sshGs...+sss.VsCP...ss.pscpGAshpCp.ls..ls.Gp.shpVsVTlsss.-G........	0	18	65	80
+14073	PF14231	GXWXG		GXWXG protein	Eberhardt R	re3	Jackhmmer:B0CA20	Family	This domain is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. There is a conserved GXWXG motif. This domain is frequently found at the N-terminus of Pfam:PF14232.	25.00	25.00	26.60	25.10	23.00	21.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.91	0.72	-4.32	50	169	2011-05-18 13:18:05	2011-05-18 14:18:05	1	2	133	0	86	180	1	58.80	39	34.55	CHANGED	hslFDpLssVss-.hl.GpW+Gutl.TGHPh-GhLpshsWaGKpFhss-sVcPLlhhss...cG	.......phassLssVps-thl.GpW+GsthsTGHshsGhLpthsWaGKpFpsspcVcPLlhhsssG.......................	0	9	53	72
+14074	PF14232	DUF4334		Domain of unknown function (DUF4334)	Eberhardt R	re3	Jackhmmer:B0CA20	Family	This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. This domain is frequently found at the C-terminus of Pfam:PF14231.	25.00	25.00	26.80	25.50	21.10	17.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.87	0.72	-4.33	50	165	2011-05-18 13:43:53	2011-05-18 14:43:53	1	2	132	0	85	176	1	60.60	45	35.32	CHANGED	sppupApLRhhpaRGtsoAoMlYDphPIhDhFR+VD-....sslhGlM-hKs.........tspsaFFhLcR	...h.ttupApLphhcFRG.....ploAoMlYDtpPlhDaF++lD-....solhGlMshKs.........psp.a.aFhLcR.............	0	9	52	70
+14075	PF14233	DUF4335		Domain of unknown function (DUF4335)	Eberhardt R	re3	Jackhmmer:B0CBF9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 204 and 480 amino acids in length. There are two completely conserved residues (G and D) that may be functionally important.	27.00	27.00	52.70	52.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.20	0.71	-4.83	55	113	2011-05-18 14:47:08	2011-05-18 15:47:08	1	1	70	0	44	125	119	193.20	27	57.39	CHANGED	+pYs.PsCoLplpGhss.h....stspscshlslLsts-sp.h....sp...lcGs+-aLcsLhpsVssYspphLS...........................uhs.p.......phst-ssh.............................................lplps........psh.tH...cLhLpu........ttsssss.................hplpLsssQLaDLlpALDphtsDspsLsshshshp.......h++ht...h..sstshhpphsssslG............................ssulslsuhhh...hhlPhPp	........hpYs.PsCoL.l.uhss.h....st..sthpshhthLp.s-sp.h....st...lpGs+phLEsLhpsVssYspphLo...................................uh.........tptph...........................................................................lplps.........sh.tH......cLhlts.................tspsss.....................htlpLsssQLFDLlpAlDpahsDspsLsshshphp........++ht....tsstshhpphsssslG.........................shulshsuhhh...hhhs.P...................................................	0	7	31	42
+14076	PF14234	DUF4336		Domain of unknown function (DUF4336)	Coggill P	pcc	Jackhmmer:Q8RWI4	Family	\N	27.00	27.00	27.20	27.10	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.86	0.70	-5.23	47	413	2011-05-18 16:09:10	2011-05-18 17:09:10	1	4	339	0	204	422	226	203.30	28	65.88	CHANGED	ssplWoFEQlQGlhY...VsVPIRMTVlKLps.GGLhVauPlAPTtEhlphlcc..L..t.cG....sVcaIlLPTsSG........lEHKlalGPhARtFPpApVWVsPsQWSFPlsLPLs..WLGhP....ps........+s..L.s........h....sss..........ssPas.DEh-athLsPlsLGlG..s.....FtEluhaH+tSpTLLVTDullulstpPPt.lhshDP............hPLLF.........HAR-p..us...csltDosps..R++GWpRhsLFuhYhpPs..sL.................pss....................ph.phh..t................h.a..tWp.sh..sFptlps.....+...LhVAPlLpsLlasRs.ptlhsWl-cl............up.W..s.....hc.........pllPuHasAPlts.sspchppAFsa	...........................................lshssRMTVl+Lss......G.......u.....LhlaSPls.TpclhptlppL.........G.sVcallsPsh..h..........H+lalssapctaPpApla....ss...P.......s...................t......ph.....h....p........hhsh..........t..t....h................t....t.pt............ss...as.s-h.-..hhhp......t..t.........hpElsFaH+sSpTLllTDhl..sh....p...........................................................................................................................................................................................................................................................................................................................................................................................................	0	66	121	171
+14077	PF14235	DUF4337		Domain of unknown function (DUF4337)	Eberhardt R	re3	Jackhmmer:B3DVT1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 201 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	27.00	27.00	30.20	28.80	24.00	26.20	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.82	0.71	-4.39	47	143	2011-05-19 08:31:57	2011-05-19 09:31:57	1	1	133	0	74	139	31	162.60	30	84.08	CHANGED	hspplAlhsulLAsluAlsshtuss.......hpscuhhppscAuspWuaYQAKohKpslhEhssphhthph............psthppclpcYppcppchcpc......ucpLppcAcph-ppp-pthcpacpashAsshlQIuIsLAulslLT+.+phLhhhuhuhussGlshhshuh	......................spplAlhsAlLAshuA.lsshtGss.......hps-A.slppscAuspWuaYQAKohKpsls-husphsthph................psthppclpcYppptpch+pc......................ucplppp..Acct-cpp-tthcpaHcashAsshlQIuIsLAulolLTc.....pphLhhh....uhslussGlshsshuh.......................	0	19	47	62
+14078	PF14236	DUF4338		Domain of unknown function (DUF4338)	Eberhardt R	re3	Jackhmmer:B3E1A9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 206 and 475 amino acids in length.	27.00	27.00	27.30	28.60	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.73	0.70	-5.75	26	167	2011-05-19 08:39:33	2011-05-19 09:39:33	1	8	64	0	33	167	423	198.60	25	54.41	CHANGED	php+cslhpLstsppp..phttpptthst.........hssspsshschhs.pLphVcstsp...pLFphhhtp.a.LsaspshGc+LRYLVhsptp....t...llGhLuhuussapltsRD.caIGWsppsR+ppLhplshsu+hL..I.Pasplhsht.hlLuhsspclpsDapcpYstpshllEs........hVsssphhG..osYptss..................Wh.lGtTpGpG+hcht..................................................hhh+ts.h+-lalhPLscshcchLps	............................................................t..................................................thht..lp.Vpp.pt........p......thap..hhtp...H.Lshp.hhGppl+Ylshsttp...............hluhl..uauusshphtsRD.paIGWs.pt+pppLhhls.ssRhL..IhPh.hpl.shtShhLuhshccl.pDatphYshp.hllEo............................alsspp..hh.G....osYptsp.......................Wh.lG...TpGhuc.t...................................................................................................................t...................................................	0	15	25	29
+14079	PF14237	DUF4339		Domain of unknown function (DUF4339)	Eberhardt R	re3	Jackhmmer:B3DVT0	Family	This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.	26.00	26.00	26.00	26.00	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.06	0.72	-4.38	59	701	2011-05-19 10:27:33	2011-05-19 11:27:33	1	48	515	0	277	694	67	44.80	29	6.35	CHANGED	paahsp.NupptGPashppLpphltsGplss-oLVW+pGMss.Wpsh	...............Wah.sp....s..s......p...p......tGPhshpplpphhtpGplst.sThlWppGhss.Wpsh......	0	109	177	238
+14080	PF14238	DUF4340		Domain of unknown function (DUF4340)	Eberhardt R	re3	Jackhmmer:B3DYU8	Family	This domain is found in bacteria, and is typically between 183 and 196 amino acids in length.	25.00	25.00	25.00	25.00	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.31	0.71	-4.60	71	627	2011-05-19 11:01:47	2011-05-19 12:01:47	1	8	364	0	213	647	246	159.80	14	62.45	CHANGED	sWp.ls.s...s.hs.......hssDpsplsshlssLpplphpchls.....ssss.h.scaGLsss........thplsltsss.......s.p..tplh.lGs..sss.s.....sp.....hYs+h..stpsplah...lss...shhshh..s.tshss....a.hspp.lh...s.h....ptsp...lpplplpt.....tspt.........hph.........spps...s.....tWph.ss....s....tt......pss.ssps..sphls.slspLpsps..hhstps......sphtthsh.ss....Pth	.........................................W..h..t......t.......h.hs.t.t.t.lp.phhptltthph.p.hp.........s.spp.htpa..GLsps............................thplplp.tts.......................t.p....hplh..lGp..s.ss.s......................sp...........h.Ys......ph......t...s...........p..s.....p....lah.....lst......shhp.h...s..ts.t..p....h.hppp.lh......p..h......t.tp....l.pplplp............tt.................hph.........................tttt..t.......th.h.tt..............................ht....h..tthht...h..h.h.t....h........................t.......................................................................................	0	128	169	184
+14081	PF14239	RRXRR		RRXRR protein	Eberhardt R	re3	Jackhmmer:A8ZLD7	Family	This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with Pfam:PF01844.	25.00	25.00	25.50	25.60	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.09	0.71	-4.86	49	361	2011-05-19 12:12:55	2011-05-19 13:12:55	1	6	102	0	87	389	36	159.60	40	43.18	CHANGED	VaVLspst+PLMPs+s.u+ARcLL+pGKAtVh+..hhPFTIpLptp..tss.tsQP.lpltlDPGu+hoGlul....hssp..cslhsuclplhhtpl+ctl..................tspRphRRuRR.sR+h.....RYRpsRFsN..R....c+..s...tW..Ls........PSlpp+VcsplphVpcLp+lhPlosIshElV+FDhQthps..P-IsGhpYQpG	...................VhVlspptpPLhPsps.u+ARhLL+pG+AtVh+....thPFTIhLpp......p....sss.........sQP.lpltlDPGu+hoGlAl..............hppp..............ps..............latuElphRtp.pl+ctL.................ppRRthRRsRR.pR+h..............................RYRpsRF.NR................p..+...p...GWLs...............PSlpp+lpshhshVp+LpchhP..lss....ls.....ElV+FDhQthpN....P-l..sGhpYQpG..............................	0	33	62	83
+14082	PF14240	YHYH		YHYH protein	Eberhardt R	re3	Jackhmmer:A8ZMB4	Family	This domain family is found in bacteria, eukaryotes and viruses, and is typically between 141 and 198 amino acids in length. There is a conserved YHYH sequence motif.	25.00	25.00	26.00	25.40	23.00	24.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.42	0.71	-4.58	57	242	2011-05-19 12:29:31	2011-05-19 13:29:31	1	18	133	0	117	242	1052	161.80	25	17.45	CHANGED	shsaplPhs..P.thu...........sps..sshsh....sshGlAlNGVsh.ssss...................t.t..s...s...hhs........................slDpssuHspssG.sYHYHuh.Ps...shhp.t...tt...ssc.............usllGaAhDGFPIY..u...hs.sss..p............................................suDLDcCNG+hsss.......GtY+YalTssa...Pal..pCa+Gs	.................................................................................p...h.lshp..P...t.............tps..pths...........sslGlslNGlsh.sshs.............................t...s.....t......................................shD.ts..sGHs....p..s.u....sYHY..H.........t......ss...shhp....tt......ssp.................................usllGaAhDGFPIY..Gs.hs.sss.p..........................................................................................t..s...s.......D..LDpCsG+hsss........................utY+....Y....asT....tsh....shh.tshhG............................................................	0	65	96	111
+14083	PF14241	DUF4341		Domain of unknown function (DUF4341)	Eberhardt R	re3	Jackhmmer:A8ZP08	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF04143. There are a number of conserved glycine residues that may be functionally important.	25.00	25.00	25.30	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.99	0.72	-4.27	233	845	2011-05-19 13:03:03	2011-05-19 14:03:03	1	3	766	0	330	765	339	64.00	36	39.15	CHANGED	sPhhuLhGGhLIGluAslLllhsGRIAGIS.......GIluu.....l........lss...................pssts.W.RlsFlsGLlhushlht	.........h.uhhGGhLIGluuslLllhs......GRlAGIS.............GIluu.l.......lss.............................tts.hs..W..c....lhFllGllhushlh...............	0	101	209	276
+14084	PF14242	DUF4342		Domain of unknown function (DUF4342)	Eberhardt R	re3	Jackhmmer:B0C276	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 97 and 206 amino acids in length. There is a single completely conserved residue P that may be functionally important.	25.00	25.00	25.80	25.30	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.78	0.72	-4.21	24	177	2011-05-19 13:27:51	2011-05-19 14:27:51	1	2	141	0	62	144	7	82.10	31	52.91	CHANGED	Epppc.shsE..chpsoss-llpplKcllcKGNVpRIhlK+--.+sll-IPVsuGlhhGsI.u.sllhPhlshlGs...luAlsschTlEIp+	.....................pph.-phphssscllctlK-llcKGNVsRIhl+K--.+sll-I..Plsssl.hGs....l....u.slhhPh.lhhl.us...huAllschplcl.+.............	0	36	55	60
+14085	PF14243	DUF4343		Domain of unknown function (DUF4343)	Eberhardt R	re3	Jackhmmer:B0C6A8	Family	This domain family is found in bacteria, eukaryotes and viruses, and is typically between 127 and 142 amino acids in length.	28.50	28.50	28.90	28.50	28.40	28.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.71	0.71	-4.30	33	270	2011-05-19 14:59:22	2011-05-19 15:59:22	1	1	245	0	46	151	7	125.30	54	49.75	CHANGED	ppshFlKPsstsK.............tFsGpVhptsp.............-ls..........ths......s.......hspc.....p.lhlS-shp.htsEaRhallsucllssuh..Y.................+ss....hchcs.....-...scshppshphh.t.....hshspuaVlDluhsp.stp..htllEhNsh.uuGhY.uscstphlp	...........................................N.WGKFIKPKAGSK...............VFTGR...VVNsT+.............DLI..........GI.......G.......LPFD.....YPIWISEVVE.FIA......EWRCFVLDGRVLDVRP..Y.................................TGD....YHAQF........D.ASV.IDEA..ISCW.K........DAPIAYGLDIGVTR..DGR.....TLVVEVNDGYALGNY..GLSPLK...ohs........	0	20	36	43
+14086	PF14244	UBN2_3		gag-polypeptide of LTR copia-type	Coggill P	pcc	Jackhmmer:Q9SKR1	Family	This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.86	0.71	-4.66	45	858	2012-10-02 13:37:57	2011-05-19 16:31:48	1	147	45	0	183	1298	0	123.20	19	15.91	CHANGED	uDsssh.Iss.h+L..sGsNYttWSpslphhlsuKsKhGalsGsl..stP.tpsD......acpWpppNuhlhuWlhNohssplhpshlhhssApplWcslt..ppappss...ssplhp....l+p..pltphp.Qs.stslppYasc.hhp.LW...-hpphp......hpsstsp	..........................................................................hL..st.p.N.Y..Wptth.hhl..tu.p.s.....h.h.....s.a...l..........s.......G....p..h..................P..................p........s....p................s..tht..pWptp.......sshl......h.uhl....h.sohs.p.l..h..pp...h....h....h..h.p.....o.up..ch...Wptlp..ph.a..sptp....tp.hhp.........lpt.....tl.thp..pt.t.pl.tah.th.....h..............................tt.......................................................................	0	20	109	161
+14087	PF14245	Pilin_PilA		Type IV pilin PilA	Eberhardt R	re3	Jackhmmer:Q59589, Jackhmmer:B0C6E0	Family	This family consists of proteins which form type IV pili. In M. xanthus these pili are required for social motility [1,2].	24.50	24.50	24.60	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.36	0.72	-3.52	48	287	2011-05-20 08:28:23	2011-05-20 09:28:23	1	8	84	0	98	303	30	100.80	20	62.61	CHANGED	pssKA+QSEA+shluulN+AQQuYhhEp..spFs........ss..lssLslsh........t..poppY........sYshsssss....................................sstt.......sssstssslpsYsuulhhsss...........ssssuslCcsssss	.............................t+u+poEA+ss.L.pulhpAQpuaahEp..spau.....................ss....hscluhss.................p....psspY..........sYplssuss.........................................h.......h....t..................................................s............................................................................	0	40	72	96
+14088	PF14246	TetR_C_7		AefR-like transcriptional repressor, C-terminal region	Eberhardt R	re3	Jackhmmer:B0C7Z3	Family	This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae [1]. It is found in association with Pfam:PF00440.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.53	0.72	-3.75	164	1183	2012-10-03 00:15:22	2011-05-20 10:40:53	1	4	683	4	387	1012	42	54.30	26	25.21	CHANGED	GpLp.lsDsphAApQFhuLhcu.th.ah..plhs....sp....ss....tt-h....ppllcsAVchFLutY	............GtLp.hsDsthAAppahuLlpu.ph.hh..tlhu......hs.....ts.s..spch...cphscpAVchFLttY.................	0	84	213	288
+14089	PF14247	DUF4344		Domain of unknown function (DUF4344)	Eberhardt R	re3	Jackhmmer:B0C924	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 247 and 291 amino acids in length. There is a conserved EED sequence motif.	25.00	25.00	29.50	28.10	23.60	23.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.59	0.70	-4.69	33	149	2011-05-20 10:11:40	2011-05-20 11:11:40	1	5	108	0	52	149	25	172.00	24	70.55	CHANGED	Y..sspssptpphpchlppsph......hEshsshhssh.hhlPpslslth.ts...u-ssshYDP-spsl..plsYchlspshp...hFtp........ts..pssptht..cs....A.ls.s.hh.aolhHEhGHAhIshhplPllG+EEDAsDplAullLlph..s-..s..Gs.......hsluu..AshFthpucc..cs.pht-hs..........ahD-HSlDhQRaYshlCllYGSDPcpas.sLlc..cut.Ls..p-RA-hCttEYpplspsWppLLp	.............................................h.ttth.......p....ht..pt..h.hstsl.l.h..s...up.sshassptttl...hsYphh....t...hh.t..............t......tt.........s.hs.shhhhhhHEhGHhhlt..plPhhG..pEEDssDphAsh..hhlp.......p..ptt..........hhhs.s.st..ah.htt.tt..t..th..p..s.........hhstHuhchpRhashhChhYGussptht.tlhp......pht.h...pcRtthC..patthtpsW.phl.t.......................	0	8	18	36
+14090	PF14248	DUF4345		Domain of unknown function (DUF4345)	Eberhardt R	re3	Jackhmmer:B0CDG7	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 125 and 141 amino acids in length. There is a single completely conserved residue E that may be functionally important.	25.00	25.00	25.00	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.37	0.71	-4.67	33	186	2011-05-20 10:55:15	2011-05-20 11:55:15	1	1	172	0	55	174	304	121.30	22	89.27	CHANGED	cthhphhLslsulsslshGlshslsssshhsstsssssss.........hcuphRahuGhalulGlhhlhuhhphphtphshhhlshhhhsuGlGRllShhhsG.hPssshlsuhlhELllsslhhhhhtth	........h....phhlhlhuhhhlshGlhhhhsstthh.s.sh.s.ssthss.........shssphR.h.h.u.Glh..hGlGlhhh..h..ssh..p..h.phhshslhhlhhhhhssulGRLlol.h.h..cG.sP.tshhhshhshE...llhs..slhhhh....h...........................	0	16	36	46
+14091	PF14249	Tocopherol_cycl		Tocopherol cyclase	Eberhardt R	re3	Jackhmmer:B0C447	Family	This family contains tocopherol cyclases. These enzymes are involved in the synthesis of tocopherols and tocotrienols (vitamin E) [1].	25.00	25.00	25.40	25.20	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.49	0.70	-5.73	22	180	2011-05-20 12:58:36	2011-05-20 13:58:36	1	3	160	0	72	189	73	263.30	27	72.89	CHANGED	sRRFFEGWYaRVTLP.EhtpoFAFMYSIEDP.hG............GpsaSGGuAQILGssDpYlCRhFP-VcpFWAStt....tpLuluH.ttps.ph.sphLsPptFpcplppGYQsTsshpQGhItDsu......osphsRWpYphpPlYGWGs.sp.QpSTAGWLSahPIFEPGWQILMAHGLATGWIEWsGcpY-FpsAPAYSEKNWGGu.FPpKWFWlpCNsFpsp.sDLALTAuGGhRpVLhh...hEsVAlIGlHY.pG+..FYEFlPWs......uploWplsPWGpWphpAcNpp.apVclpusTp.ps......GTsLRAPT.pp...GLtahCRDThpGclpLpLhp..........ppsclIlcupSshuGLElGG	......................................................................................................................................................................................................................................................................................................h...................................uhhGhhu.hl.PhhEstWplh.hhtGh.us.Ghl.....phs.Gcpa-F..s..su...u..YsEKNWGtu.FPpcWhWl.Q.sNsFp....st......ssl....ulssuGuh.htl.hhh.......hcs.su..ll.u.l.ah..pGp..hYcF.sshs..................utl.....ph.p.l...p...s.h.u..p.Wplpu..p......s....pp....a.tlplpu.ps.p..p.......G.p...L...p..A..P..s..tp....sht...tsc-ohtGplplplhc.................psphlhpspo..phuulEhGG...................................................................................................................	0	30	57	67
+14092	PF14250	AbrB-like		AbrB-like transcriptional regulator	Eberhardt R	re3	Jackhmmer:A8ZQN0	Family	This family of DNA-binding proteins is likely to act as a transcriptional regulator [1]. This family does not include E.coli AbrB, Swiss:P75747, which belongs to Pfam:PF05145.	25.00	25.00	25.30	27.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.40	0.72	-4.07	31	183	2011-05-20 13:30:59	2011-05-20 14:30:59	1	1	74	0	80	187	216	70.60	55	54.51	CHANGED	sFhsALL-Ac....GlsLssps....supsptGRpsoYRloVQsNGNLLIGuAYT+pMsLpPGDEFEIpLG+..KH..I+Lh	.sFYcALL-A+....GlsLsssu......tupuptGRpsoY+soVpuNGNLLIGpAYTcphsLcPGDEFEIcLG+..Kp..I+Lh.......	0	12	53	71
+14093	PF14251	DUF4346		Domain of unknown function (DUF4346)	Eberhardt R	re3	Jackhmmer:B0BZ08	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 127 and 502 amino acids in length. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and Swiss:Q57571 has been shown not to possess dihydropteroate synthase activity [1].	25.00	25.00	25.10	25.20	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.45	0.71	-4.37	36	151	2011-05-20 14:28:43	2011-05-20 15:28:43	1	4	138	0	83	154	139	92.90	40	30.70	CHANGED	pslDcpLSpRaIsLDPuGYFlIhlD+csuhIsAcHasNsIs-+GLAsDPETGEslsC+G.psp.R.sssslapGRTAKELulplhEp.ppssPlopLDHAhYLGREhp+AEhsLlsGpcYlQD	...........................................t........................................................................h.h.........p.pspthhpG+oAKclh.plhEp..t.s.....lopLDHAsYLGRELt+AElALhpG.p.pY..lQD.......	0	20	55	73
+14094	PF14252	DUF4347		Domain of unknown function (DUF4347)	Eberhardt R	re3	Jackhmmer:B0CAL0	Family	This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	24.60	24.60	24.70	24.80	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.91	0.71	-4.75	113	300	2011-05-20 14:50:08	2011-05-20 15:50:08	1	150	158	0	134	354	204	155.90	31	6.72	CHANGED	pllhlDusVs-hppLlsulh..........s........ss........c.....lllLDsspDG....lpQIsphLpsp.....s.slsulHllSH.G.ssGsLpLGss.pLstssLsp..hssp...Ltphup..sL.stsu-lLLYGCsVAu..G.....stGppFlppLuplT.GAcVAASsshTGssthG.Gc.WsLEhp.sGs.lpssh......shsttshssYsulL	....................................................llhlDusVpchpsLlsulh............................s........ss........p.....lllL-sspDG....lpQIsphLpsp...........s.slsulHllSH.G..ssGplpL.Gs.........s...hLsts.sLts..hssp......Ltp..h..sp..........sL...stsu-.....lLLYGCslAs...u...................ttGppFlppLup...lT.GAsVAASss.hTGssthG.Gs.WpLEhp.hGp..lpst........hh.....tta..................................................	0	34	87	114
+14095	PF14253	AbiH		Bacteriophage abortive infection AbiH	Eberhardt R	re3	Jackhmmer:B0CCK0	Family	This family of proteins confers resistance to bacteriophage [1].	24.90	24.90	24.90	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.12	0.70	-4.79	44	409	2011-05-23 08:00:20	2011-05-23 09:00:20	1	3	336	0	51	289	12	245.00	19	82.16	CHANGED	LaIIGNGFDls.HGLpTpYpcFt.pYl.....................................ppp................................................cpp...lh...ct...lt......................chh...p..ttp.hWs-hEpsLu.cls.....hc.........................pp...............h.tth..p....chh.-..shpc........hhphp..p....pt.h.p.hh..phphpp...........hhp.chh.p......hphhp.....p................hhtpph...hp..ph...h..pppshF.loFNYTsTLEplYsls..pl.alHGt.pt................pplhhsHG.......st...pt...s.hh.........s.hs-c...................pchpptp..........h.h........tps...hh.phhh+shc....spthh.p..pppthhptl.s..sl.........pplhlhGaSluclDhsYhpcIhppl....sssph.hhhaas	................................................................................hIlGNGFDlt..a......GL....p........TpYp.-Fh..pah.............................................................................................................................................................tp.......................................................................pt.hh...p....l.......................................p.h.........t.p..tWsDhE.plu.phs....pp.....................................tp..............................................................h...h..p..p.hh..s..p.hpc................hhtht...p.....p...h..p.......t.ph.p.........................................hhp.phh.p............h.hhp.....p.............................................................h.htth......p..p...........pp.s.h.lsFNYT..p.s.......lp.p.h.ht............th...pt...................t..hhhHu.....p....p....s.hh...........s.hscp.............................................p...p........................pp.....p.hhpthh...........h.p.....p....t.l..t..s...........................p.lh.lhGhSl...ut...s...Dh.happlhpp.......ss...hh.......................................................	0	18	37	44
+14096	PF14254	DUF4348		Domain of unknown function (DUF4348)	Coggill P	pcc	Jackhmmer:Q64RZ7	Family	\N	21.10	21.10	21.10	21.10	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.78	0.70	-5.29	14	97	2011-05-23 09:07:11	2011-05-23 10:07:11	1	1	93	2	12	80	0	259.60	43	95.51	CHANGED	lhl.ulhh.LhlhsuCssp.psctcP.h.us..optlDSspscssDo.s...phlsEpPh.PtsADEhFDDFhFNFAuscKLQ+pRlpFPLPhY.pGcp.spcIcKcpWKhD.hFp+QsYYTLlFDpccpMchsKDTslsSVhVEhIaLcp+pVKpYaF-RhcGpWhLpuIshpsh..ccstNtsFlpFYp+FusDShFQtppl+pPLtFsssDPD.D-FshlpsTlsspQW.uFpPt.L.PpsplhNIhYGQK.s-.ospKIlsl+GluNGhps.LhF+++tspWcLhK	.......................................hshhl.lhlhsuCusp..psshDP.h.so..op.tl.DSh.t.pps-o.p....shlsEpPh.PtpADE.FDDFhaNFAusctLQ+pRlpFPLPhY....succ.....pspIcccpWKhD.hFp+QsYYTLlFDp-cpM-hstDTsL..sSV.VEhIalKp+hVKpYaF-RlcGtWhLpuIshcsh..cpst.NtsFlcFap+FssDShFQtpplppPLt..Fls.sDPD.D-FuhlpTTlshsQW.uFpPt.L.Pt-tl.NI...YGQ+....s-.SspKIlsl+GIuNGhps.LhF+.++sGpWcLhK................................................	0	5	10	12
+14097	PF14255	Cys_rich_CPXG		Cysteine-rich CPXCG	Eberhardt R	re3	Jackhmmer:B0C8L0	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are 5 conserved cysteines which occur in a CPXCG motif and a DCXXCCXP motif.	25.00	25.00	25.10	25.50	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.99	0.72	-4.14	50	377	2011-05-23 09:38:52	2011-05-23 10:38:52	1	1	360	0	122	303	213	51.30	39	80.52	CHANGED	lsCPaCGcphclhlDsSsG.sQpYhEDCpVCCpPIphpl.pl.D.-s.phplplts-	.......hpCPaCGctlpl.hlDsSsG.sQpYhEDC.lCC+PIplsl.pl.D...ct..c.plplh.-................	0	34	63	97
+14098	PF14256	YwiC		YwiC-like protein	Eberhardt R	re3	Jackhmmer:B0C8C3	Family	The YwiC-like protein family includes the B. subtilis YwiC protein Swiss:P46909, which is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	26.00	25.90	24.30	23.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.97	0.71	-4.06	64	369	2011-05-23 10:22:13	2011-05-23 11:22:13	1	1	357	0	79	307	2	127.30	34	50.68	CHANGED	lPsQHGAWuMlllPhlhGh.huu................shhp.lh............L..hluWhh..hYlhpaPh..hhhlKp.+p........ptp....ahph........h....hlY......u.....sluhhhslhslh.hps.pllhash.sh.lPLhhlshaastp+cERuLlN-lsullshulhuhs..ua.hh	.....lPpQHGAWsMlllPFlhGhhlus.....................P..shhH..l.............L..hluWhh..hYLssYPh..hhhlKp.+p..........pcc....ahph........sllY......h.....sluhlhulhsLl.hp..pllhash..shlPLhhVshYas+pKpERuLlNDluullshslhGhsuhh............	0	19	48	66
+14099	PF14257	DUF4349		Domain of unknown function (DUF4349)	Eberhardt R	re3	Jackhmmer:B0C5Q6	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 282 and 353 amino acids in length.  There is a single completely conserved residue D that may be functionally important.	24.40	24.40	25.50	25.10	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.40	0.70	-5.16	99	422	2011-05-23 10:50:48	2011-05-23 11:50:48	1	4	385	0	188	435	178	256.80	18	81.31	CHANGED	l..su.Cuusss............................s.............ss.......s.............tsssus........s..ss...sts.sutts.................................sss...s..ss....sss........ss....ss.......s........s...................p.p..lIp..su..sls..lps..ps...hspshsplpshspptu.Ga.lssps......p..t......tts.ssptpuslslRVPssph-shl....spl.p......s.l.....G.pl..pspshsucDVTpphlDlcuRlcshcspppRLhpLh.p.+As...slpDllplEppLuplps-lEulpuphchLpspluhSTlslslpp......t.ss....sp...s.....shh..sthtsuhpsuh....sshh....s....hhthlh....hhl....s.sllshhshl.h..lhs.h.ls.hhhh+	...........................................................................................................................................................................................t................t.......t.t..t...s................................................sss.s..ts.......sss.......ss....ss...........s........p....................................pp...llp..su..slp..lps..ps...lspshsplpshspph..s.Gh.ltsps...............t..p..................tsstptpuplslRlPs.s..phcshlsplp.......ph.....G..pl..p.scshpupDVTp.......phh.Dlpu.RlpshptpppRlhplhp...cAp....slp-.llplcpcLu...plpscl-phpuphp.lppplshuTlslshpp......................s......ttt..........sh....tthh....p.u.ht.tuhpshh....thhthhh....hhh....s.h.hlshhshh.h..hhhhhh.hhh.............................	0	92	150	173
+14100	PF14258	DUF4350		Domain of unknown function (DUF4350)	Eberhardt R	re3	Jackhmmer:B0C323	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.32	0.72	-3.77	163	383	2011-05-23 12:43:26	2011-05-23 13:43:26	1	4	379	0	148	374	7	71.10	21	18.23	CHANGED	sssssGs.tuhtp....hLpp....p...Ghpl......pthpp..s.hs...th..s..s................s....ss.....ol....lllsss..ht..hst...tphp.pl...hpalp..pG.s..plllss	..........sspspGs.tAhtp....lLps....p....GhpV......phhps...s..hp...ph..s..s.................p..ss.....oL....lllsss......t..hsp......tphp.tL...hphsc..tG.scllls.....................	0	44	100	136
+14101	PF14259	RRM_6		RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)	Coggill P	pcc	JCSG:Target_421663_WS20613B	Domain	\N	27.00	18.00	27.00	18.00	26.90	17.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.07	0.72	-3.99	76	8811	2012-10-02 20:46:34	2011-05-23 13:46:14	1	359	393	72	5363	52886	951	69.90	20	16.00	CHANGED	lhlpsl.s....s.sst.pclhphhst....h.s.p.....l....p.slphh....t..p..............pst..Ahlph..s...stp.sAppshpp...h...p...hh..l..ps+hlc	..........................................lhlpsL..P..h......s..s..o....p....p....-.....l........t.....p....h....F.p.p..........................h..u..........................l..............p..sl...p..lh.....................h......s......t...t.....................................pu...h..........A.a.......V..........p....F.........t.................s..tc....p....Ap...p...A.l.pt......h......p....h......h...tsp.l.................................................................	0	1680	2599	3942
+14102	PF14260	zf-C4pol		C4-type zinc-finger of DNA polymerase delta	Wood V, Coggill P	pcc	Jackhmmmer:P30316	Domain	In fission yeast this zinc-finger domain appears is the region of Pol3 that binds directly to the B-subunit, Cdc1 [1].  Pol delta is a hetero-tetrameric enzyme comprising four evolutionarily well-conserved proteins: the catalytic subunit Pol3 and three smaller subunits Cdc1, Cdc27 and Cdm1 [2].	24.00	24.00	24.20	24.10	23.20	23.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.34	0.72	-3.97	123	623	2011-05-23 13:01:37	2011-05-23 14:01:37	1	15	346	0	405	635	5	74.40	35	5.48	CHANGED	Cl....s.Cc.s.lppt................slCppC.t..spp....sslh.phhschpphEp+...hscLhshCppCp..............ushtpplhC.sSpDCPl.FYpRt	.................................................................................Cls.C+s.lpptt......................slCspC..p....spp.....splh.phlsclppLEp+ascLhotCQpCp.................Gohc.p-VhC.sS+DCPl.FYhRh......................	0	141	227	345
+14103	PF14261	DUF4351		Domain of unknown function (DUF4351)	Eberhardt R	re3	Jackhmmer:B0C7B5	Family	This domain is found in bacteria, and is approximately 60 amino acids in length.	25.00	25.00	25.00	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.76	0.72	-4.10	123	513	2011-05-23 13:20:27	2011-05-23 14:20:27	1	8	115	0	203	604	76	61.60	34	25.98	CHANGED	p-Gc....pc....................tt....t.sLlLR.LsRRhGplssp......ppIpsLSlpQLEsLu........EALLDFsslsDLpsWL	.............................................pGhpc............up....tpLllR.LpRRhG.plssphp....ppIppL.s.l.ppLEsLu........EuLLDFssl...pDL.tWL.............	0	62	162	200
+14104	PF14262	DUF4353		Domain of unknown function (DUF4353)	Eberhardt R	re3	Jackhmmer:B0P678	Family	This family is found in bacteria and archaea, and is typically between 262 and 279 amino acids in length.	25.00	25.00	25.60	25.00	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.05	0.70	-5.18	51	568	2011-05-23 14:50:37	2011-05-23 15:50:37	1	12	299	0	137	543	7	204.70	25	61.88	CHANGED	Glslsus....s.V.TIosuGTYhlSGohs..sGQIlVsA.sc...scpVpLlLcGssIosossusIhVps.AcclhlsLu-GTpNoloD....uupas........tsspssAAIaS+sDLTl.sGsG.sLsVsushssGIp..S+DsLhIsu.GThsl....sA.scculpGKDuVpI.....ssGs...lsl.sAssDGl+Sc.....N--D.....sscGhlhIsGGslTIsAG.sDGIpAssslhIsGG.s....lslss.......................uscGlcutt.l...slsGGslslssu...DD..Glpust.........................plplsGGsh..slsuuc...DGlc	.............................................................................................................................................................................................................................................h.s...h.h.....t.......s...l....lt.u...t...tp...ul...sp.....s.s......lhlt.s..G.....s..h..pl.....p.u....s.....tcul.....pup....s....tlpI............psGs.....hsl....su.......s....s.......D...ulcus...............ttp.p...........................tt.G.h.lhIsG.Gsl....sl.........s....u...u....s......D.....G.lcA.........s.........ss....l.hIsuG.s..........ls..lps.............................................................u.cGlcu..t.slslsGG..sls.l.us...sD....ulpus.......................................................st...............................................................................................................	0	82	123	133
+14105	PF14263	DUF4354		Domain of unknown function (DUF4354)	Coggill P	pcc	JCSG:Target416839_SP17692A	Family	Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop) proteins, but this could not be confirmed. The one PDB:3NRF structure solved for this family exhibits an immunoglobin-like beta-sandwich fold.  Crystal packing suggests that a tetramer is a significant oligomerisation state, and a disulfide bridge is formed between Cys 125 at the C-terminal end of the monomer, and Cys 69.	25.00	25.00	25.80	29.00	24.90	24.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.57	0.71	-4.43	10	100	2012-10-03 03:07:29	2011-05-23 16:13:37	1	1	97	3	13	46	1	121.80	51	96.22	CHANGED	MKp..thhluulALsuh....shsAsAsssDslhVaATppopGolSlGc+shYTKsFcVsVsNhucpsIDLsph..Ch+AauscG+cF+lDTVDEcLspGoLKsGpsVKGhAVFAS-scSVYpAshVKlSss	...........hKp..hhhhshluhsuh....sShApsAussslMlhATscopuus..SsGDKsFaoQTFDluVANsuuoDI...sLcKl...CFlAluscGKoFssDTIDpKLToGlLKsG-SVKGFAsFAusDcSlYcsplVKhS-.s.......................	0	3	8	11
+14106	PF14264	Glucos_trans_II		Glucosyl transferase GtrII	Eberhardt R	re3	Jackhmmer:B0P6U7	Family	This family includes glucosyl transferase II from the Shigella phage SfII, Swiss:O21944, which mediates seroconversion of S. flexneri when the phage is integrated into the host chromosome [1].	25.00	25.00	27.00	27.00	24.00	21.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.26	0.70	-5.43	56	371	2011-05-23 15:20:29	2011-05-23 16:20:29	1	1	254	0	42	303	10	302.20	21	64.26	CHANGED	hhshlhsshhh.hD-....stsh.h....uhtsW..........hp...GR.hhphlhphh....hpsh....hsh.s.hstl...Luhlhluhuuh.ll...sp.hh...shp..........p...phh.sslhshh.h.hssPhhl.pph.uapasuhthululh.husluhhhh..........p.............pp...p..h.thlh.uslhlh.huhshYQuhhs...lalslhlhhhlhph.............l.csp.....tshpthhh.tlh....p.lhh..hlhuh..slY..hlhhplh..hhhh.psphssh..t..spht...h...tshhps.lhpshpph..hphht......t.sh.hhhh..hlhlhllhhlhh..hhhhhtpph.....p...t.h.thhlh.l.lhhhhhP..hhh.h.....lhlh...hs.s.......shhps.........hhshshs..h.hh..hhh.llh	.......................................h.hhhtsh.h.lDD....t+tht..........uhtsa..........sp...uR.h.phlphhh....spth...hsh.shh.s.l.....Luhhhlulssllh...hh.hh.....stp..........p....shh..shlsshl.hhhs.PhFl.psh.uFpasu.hhululh.huhlshhhh..........p..................ps...p..h.hhlh.uhlhlh.hhhshYQushs...lalslllhh..hhhpl.............l.ptp.......htthhh..hhh....t.hhhhlhuh..lhY..hlhhph.........ss..ptsth..ts.tpht....h...........tch.ps.lhpshpph......hp.hht.........psh...hl..hll..h....h.llhllhh....hh.thhp.p......t.....hh..thhhh.l...lh.lhlss..lh.h...h......lhlh.....hsp........hhts.........h.tashsh.sh..hhhh..h...................................	0	14	20	26
+14107	PF14265	DUF4355		Domain of unknown function (DUF4355)	Eberhardt R	re3	Jackhmmer:B0P709	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 180 and 214 amino acids in length.	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.81	0.71	-4.17	85	633	2011-05-24 07:17:12	2011-05-24 08:17:12	1	2	519	0	57	462	6	126.50	21	66.38	CHANGED	ppp.pt...cphscp-.....lschls..............cphpchcpc.....pp.....................Eu...........c+...l.uchss.c-.......+.tc.....h-hcph.......pc.......cl...pchctphpppchp.....spspphLs-pul..sss........hhs..hl.........l..ss..DsEp....sppslcsh...pph....hs...pslpptlc.cp....l+us	........................................p......pphsppc......lsphlp...............cphpphcpc..tpct...................hp..Es...........ccl..sc.hst.cc........c.tp.......hchcph.......cp........-l.......pph....cspht....ppchp.....sps.pphls-tsl...sss........lls..hl.........l..ss..ssEp....scpslcsh...pph.......hpphlppthp.tthpt...................	0	17	36	47
+14108	PF14266	DUF4356		Domain of unknown function (DUF4356)	Eberhardt R	re3	Jackhmmer:B0PD80	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 540 amino acids in length.	25.00	25.00	25.30	26.40	24.80	24.30	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.67	0.70	-6.09	10	232	2011-05-24 08:09:00	2011-05-24 09:09:00	1	3	178	0	31	192	2	426.50	34	89.65	CHANGED	sps...hsasplAsRlLGsPp....Dcs-YaNpLacLpps.pshphhpppLcKpIsscc.h...QclpcIHs......lspcp...oVs+hlAaLsucpll....s+cssslh+Rpl+pAhhpVl..E.ha...+cp.sLs+s....c..s.....hlVcLls...Wlpsalsphhcshchc...cphPKVVWYG-sscSplYFLaaLhhlGCDVLlFHP..s.pscDsFpcsD.E.p.h.hl.hphs.sossLEPFPsEc..sRpuTV.AY+uo+ElEplLas.DSul.YKPWQF+casPhoVTLKTTYDELFllsKE+AhlRPsFcsscs.oVsIPNlFAKIsGVoc.DppEYWs+l+sLt.s.p-Tphlps.FP.FTcpp..puNap.aapcsls...csGcIcs-cLhpSslWpYpcLs-GlQcuIAcsIpchCcpPhlK...tE..p.spD.ltlalFsQlsplssslLcLIQsFDYoQslPKlVlYpo-psspLoRsDAssLlFLNclGlDIllYNPsGapsIEpYI-cstFDsHaL-EhlFsLpa+EsSt......ppll+KLF	.............................................................p...htashlhsRllGl.p......D.s-YhscLachsp....s.h....t..t....h....hpt.pslsc..sIsscp.h....pc.l..t.l+p..............tt.pt........sss..ch.lupLssppLl....hpss..cLt+h.l.+psFhslL..cla.....ccp....p.ppl.....K..s.....Fhlchlp..h.ppalsphhpshshc..........cphP+IlaYG-..hp.csclYFLhaLhhlGCDVLYhpP........c.sc-sapp....l......Dpctp.h..hh..h...phs...tphslpsFP..ccc......p.RhuTl.AYpAo+EI-plLaptsShlYKPWQFcsass.shTLKTTYDElhllhcEcAhlRPsFhspsp..plhIPslFAKIsGVpp.spc-Yapclcslt.s..pso...h...hl......pshP..ascpt....psshp...pYp.ph..ls....................ptGplc.-hlhpSpha..appLspslQptIhctI.chhcp.hhh.............................p..p.pp-..htlhlhtpl.pls.plLc.lppFDYspplPKlllapspps.plo+pDuhlLhFLNplGhDlhhasPsGhssIE.aIp...tthaD.HhL-chsas.phpt.s...........hhptlF.................................	0	12	24	26
+14109	PF14267	DUF4357		Domain of unknown function (DUF4357)	Eberhardt R	re3	Jackhmmer:B0PED6	Family	This domain family is found in bacteria and archaea, and is approximately 60 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.	25.00	25.00	26.10	25.20	24.10	24.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.51	0.72	-4.37	54	287	2011-05-24 08:19:50	2011-05-24 09:19:50	1	13	270	0	82	286	23	52.60	34	16.61	CHANGED	RppLlssGll.tt.ps...sp.hlFscDhhFs.SPSsAAullhGpssNGhhpWK.stsGpTLc	......................phhtpthl......t..........tt.hhhscDhhFs.SPSsAA.shVlG.p.o.sNGhspWK..stpGpoL.........	0	37	65	72
+14110	PF14268	YoaP		YoaP-like	Eberhardt R	re3	Jackhmmer:B0PGJ1	Family	The YoaP-like domain is found at the C-terminus of the B. subtilis YoaP protein Swiss:O34983.  It is found in bacteria and archaea, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00583. There is a single completely conserved residue A that may be functionally important.	25.00	25.00	30.30	29.10	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.11	0.72	-4.73	37	211	2011-05-24 08:34:33	2011-05-24 09:34:33	1	4	169	0	37	184	5	43.80	38	17.89	CHANGED	PlphI+lcohEcApssPssFssaulFYsGcFlTscl..l.scppFcK	........hphIcl-ohcpApssPssaTsaulFYsGcFlTscl..h.spp+hc+..	0	22	32	34
+14111	PF14269	Arylsulfotran_2		Arylsulfotransferase (ASST)	Coggill P	pcc	JCSG:Target416597_Pfam-B_1234 (release 25.0)	Family	\N	27.00	27.00	27.00	27.30	26.60	26.80	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.97	0.70	-5.27	23	447	2012-10-05 17:30:43	2011-05-24 10:41:10	1	8	258	0	240	647	295	268.60	28	56.51	CHANGED	+sQhLpspsVlsaWsGshht..hGaGaGtlplLssoYppIapVTlsss....aho..-.psh.SalDhHEupl.oscGTllV..ouhNlTptDLpslGG..p-sahhDuhhaEIDIpTNcllFcWSAl-Hlsplslp..........up..tslsssssspcpPa-haHlNSV...........spas-.sYLlShRahsSlahlp.ps.......GsVhWplpG.pG.GDFph..sss..FsaQHDsRlhppo.....c-shslSlaNN.......sNosh.......ststsTTGllhslDhp.s+psohh+plh........sspcsltSsoQGsaQlLss........uHlllsaGshs+.lcEaDssGplVhp...spFG	.......................................................................................................................................h.......................................................................................th...h..c...hH-hp.....h...h...ssu.s.h.Lh......ss.h.p.......h...t.........D....l..s......s...h....GG.........s....p....p...G......h.........l.ssl.....h...............p..................El.......s...h...c....G....-lla-.Wpuh-Hl.s....p.c.h..................................................h.ts...h..........................s.....t.hcahHINul................sh.s.p.-......G....p...h.L.l.ShRpssulhhls...t..po.................G.cl........lWch.....t.......G....................................................................t..........s....h...u................Q....H.sschh............................ss..s..sIhlFDN..................us..h.........tssss.s..spu...h.....l..l..c.l.D..........p.........pths..h....h.cph.h..............................sss...h...hSs...GusQ.h.LsN...........................GNshl.......s......ush....ut...lhEhss-G..c..slhch...h............................................................................................................................................	0	43	114	194
+14112	PF14270	DUF4358		Domain of unknown function (DUF4358)	Eberhardt R	re3	Jackhmmer:B0PFB1	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length.	25.00	25.00	25.30	25.30	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.17	0.72	-4.16	55	201	2011-05-24 09:45:12	2011-05-24 10:45:12	1	3	148	0	17	159	5	106.10	19	57.92	CHANGED	pplppsss.....h.p..phpchssptlcph..a.slssschcshhhhtust..sspssElhll+sp-sp.scsVcsslpp+lpsppps.acsYhs..-..phphlcsuhlpp..cGsYlhhllup	................................t....tsh....h....phpphs...sptlpph..a.uls.sthpshhhhhsh...shpss-lhlh+sp-tcth-slcpslppphcspppp.apsYhs...c..phphl.csutlps..cGsalhhhh.............	0	14	16	16
+14113	PF14271	DUF4359		Domain of unknown function (DUF4359)	Bateman A	agb	Jackhmmer:B1XKA9	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. There are two completely conserved residues (P and S) that may be functionally important.	27.00	27.00	30.00	29.80	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.16	0.72	-3.67	39	182	2011-05-24 11:53:38	2011-05-24 12:53:38	1	2	174	0	36	127	19	107.00	39	71.17	CHANGED	usshshTNPupp-YppaAuppLsph..hpp-lCt...pphshhLt........hhpsCspLlsst..pstltpllsptTpRpNahlFSlYpT-lshps.......hstaphp..TlGlhspFhshpsp	.h.lhLA.oNPo+s-Yp-aAucphhpp..ls+clscs..csppu.hLss.......lsussc+Lscph...scPplshlI-phT+RssYlhFSsYpTEaclss...............pY+al..slGhuphFlsl-h.s...	0	8	23	32
+14114	PF14272	Gly_rich_SFCGS		Glycine-rich SFCGS	Eberhardt R	re3	Jackhmmer:B0P5U8	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There are a number of highly conserved motifs including an SFCGSGGAGA motif.	27.00	27.00	144.60	144.40	26.40	25.20	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.43	0.71	-4.21	9	314	2011-05-24 12:25:02	2011-05-24 13:25:02	1	1	314	0	37	103	2	114.80	81	95.98	CHANGED	lpVVIGDRLGKGppVAKGVEpAGGpAlVIPGMGADMKLGDVMppEsADlGISFCGSGGAGAlTApTKYGY.s+aGMRSV-EGVTAIp-GppVLGFGFMDpEELG+RlsEAahKKa	...ITVVIGDRLGKGQKVAtGVEpAGGRAVVVPGVAADMKLGDVM+uEsAsFGISFCGSGGAGAITAQsKaGYKAKYGMRSl-EGVTAINEGssVLGFGFMDKEELGcRLVpAapKKa..	0	4	9	23
+14115	PF14273	DUF4360		Domain of unknown function (DUF4360)	Bateman A	agb	Jackhmmer:B1XRI1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 200 and 228 amino acids in length. There is a conserved GCP sequence motif near the N-terminus.	27.00	27.00	33.10	32.00	26.40	25.10	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.37	0.71	-4.63	14	198	2011-05-24 12:27:51	2011-05-24 13:27:51	1	4	87	0	146	193	13	174.30	29	79.62	CHANGED	sspplpIhssshuGoGCPpGosus..slSsDpT....hhohuFDpF.s.lGs...Ghs.ss-ppKNCpLclsLp.aPuGFQaull-usY+GaApL-tGlTGohhooYaFSpssspsss...........oppohpGs...hpG.sYshp-plsssuhlaSsCG...ssu.Ls.INsplsL...Tu.ssusssGphopDsssls...hsQplpltW+.......sCs	...........s.stplpItssshsGoGCPpGosss..slosDpo.....shTlta...s.pahAp.hGs...sss.ss-pRKNCQLslslp.hPsGa.pau..lhs.s-Y+GaA..pL..ptGsoG.s.pusYYFsG.tsppss...........sppshs..GP....hss.saphpDpssh....s.s.....hhWSPCG......sps.LN..lNsplpl.....su...ss..tp.s...tuh.hs.Dshsss...hpphhphtWppC................................................................................................................	0	54	101	127
+14116	PF14274	DUF4361		Domain of unknown function (DUF4361)	Coggill P	pcc	JCSG:Target_416718_SP15308B	Family	\N	25.00	25.00	27.20	26.40	24.90	23.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.08	0.71	-4.58	20	68	2011-05-24 13:04:20	2011-05-24 14:04:20	1	1	29	8	8	59	0	161.40	39	48.06	CHANGED	YpKALL+lhPFNDYSGsYSuTsh..pla..h.sGs......spshstss+puaVVD-pTIFFYAGhlsE-h..pDRcpYKlhhpF.........s..pc.........t......slplpss.ssssslpFcl..........hs..psoYplspphDss+PYLc++alolp.lsYcasDhTos....Puh.lpY+VcGohoMpRpI.NTpIPD	..YpKALLRlhPFNDYSGsYouosh..pla..hpss......ssshspss+pu.aVVD-pTlFFYAGhhsE-h..pD.RcpYKIhhpF.........s.s-.................s......slslpss.sssschpFcl...........hs..sPoYplspphDsspPYLcH+alsIp.hsYpasDhTos.....sh.lpYcVcGolohpRpl.NTpIPD..........................................	0	7	8	8
+14117	PF14275	DUF4362		Domain of unknown function (DUF4362)	Eberhardt R	re3	Jackhmmer:B0PHJ6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 93 and 146 amino acids in length. There is a conserved IRIV sequence motif.	25.00	25.00	25.40	27.70	22.90	24.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.32	0.72	-3.95	8	109	2011-05-24 13:06:54	2011-05-24 14:06:54	1	2	92	0	9	83	0	89.60	44	60.27	CHANGED	KKNDVVVK.GstISNLDKFEpFVlNV-QGcVDKIRIVpYTcEGDPIFQTLEaSGpDIlYV.DNRpschhAGcpKGLaKDSCKSIVK.EQREsposYRLI	....................psD.ll.p.tst.l.Nlc+h-pFlhNl-pscs...DcIRIVpYTpEGDPIFQsL....Easu....p....cIhYshDsRcD.p.FsG.cpKsl..h..KDSCKpIVK.cp+EstssY+Lh...............................	0	5	8	8
+14118	PF14276	DUF4363		Domain of unknown function (DUF4363)	Eberhardt R	re3	Jackhmmer:B0PHJ0	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	26.40	26.40	26.50	27.50	25.30	26.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.21	0.71	-4.41	34	185	2011-05-24 13:21:49	2011-05-24 14:21:49	1	1	150	0	49	144	2	115.50	22	93.11	CHANGED	hlslhlhll.llhhshastphltpsspclppplsplpptlcp.pcapcAtpphpch.ppWpcppphhslhlsHpElDsIshpls+LppalppcspspuhuplptlKhhlp+lhctEphslpNI	.............................h...hhlhhl.llhhshh..phltp...t..s...cplp.pp...lsplppplpp.ccWppAtpphpclpppWpchppthshhlcHp-lDp.lshslt+lppalpscscstuLuplphl+hhlppl.p.p..plpNI...............	0	26	44	47
+14119	PF14277	DUF4364		Domain of unknown function (DUF4364)	Eberhardt R	re3	Jackhmmer:B0PBH9	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 180 amino acids in length.	25.00	25.00	25.00	26.20	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.74	0.71	-4.63	61	224	2012-10-04 14:01:12	2011-05-24 14:37:29	1	1	223	0	42	169	12	161.20	32	91.48	CHANGED	hKLllLYhLc+lchPLoNsQlochlL-psassYFpLQpslsELhcushlphc..pcspshYplTcpGccsLphFpscIspslcccIcpalp.p.p.hph+c.-ss.lpuDYh..p.sssspYh.VchplhEs..sssLl-LpLsVPsccpActlCspWcpp..sp-lYshllshLh	..............KLllLYlLc+lchPloNsQlochlL-.ppahNYFpLQQhLsELhcushlphp..tpspp..........hYplTccGccsLphFts+Is..tshhcclcpalppp.t..pl+p.Esplhu-Yh..t.pssspah.VphplhEs..spsLl-LplsVsoccpActICspW+pp..up-lYshllptLh.........................	0	27	38	40
+14120	PF14278	TetR_C_8		Transcriptional regulator C-terminal region	Coggill P	pcc	JCSG:Target403231_MJ9673J Pfam-B_17743 (release 25.0)	Domain	This domain is a tetracycline repressor, domain 2, or C-terminus.	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.33	0.72	-3.60	44	1050	2011-05-24 13:50:59	2011-05-24 14:50:59	1	4	678	0	160	662	5	77.60	21	39.73	CHANGED	thh.hpplhphltcppchhphlhstp.tsssa..hpplpphhpphhhphhppthhptst........hh.hpahsuGhlullppWLp	............hhpplhpalt-Npcah.+sllpsp..tsspa....pp+lpchh..p.pp.h.h.p.h..h..s.htp.ptsh................hh.hsahsuuhlulIphWl..............	0	55	104	138
+14121	PF14279	HNH_5		HNH endonuclease	Bateman A	agb	Jackhmmer:B1XMH2	Domain	This domain is related to other HNH domain families such as Pfam:PF01844. Suggesting that these proteins have a nucleic acid cleaving function.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.55	0.72	-3.97	15	136	2012-10-05 18:28:12	2011-05-24 16:05:27	1	1	131	0	21	135	168	68.00	50	23.01	CHANGED	CIlC+c-hscpshs..-EHVIPsoIGG.....ph+hps.lCcpCNscLGpslDsplscphh......phhpthhcIcpc+Gpss	............CIICR.....KDTKE.LS.......EQ.aVIPEILCG.....aYF.T..NS...I...CD..oCpEpho....TNIDRPLIRHKLu...........hKIEpMKtp..hp.s....................	0	5	11	15
+14122	PF14280	DUF4365		Domain of unknown function (DUF4365)	Bateman A	agb	Jackhmmer:B1XQ96	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.	21.90	21.90	21.90	22.60	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.46	68	263	2011-05-24 15:26:30	2011-05-24 16:26:30	1	15	243	0	94	248	14	142.10	19	38.93	CHANGED	pptuhshlpth........hsph.salhc...psptDhGlDu........lEl....hs...ssp....soG..thls...VQlKuspshh.................psstshphthp........ppchsYWhp.tslPVllV..lhssssp........pha......Whplppthh.........sppptplplspss.hhsspshsplhphsttt	...........................p.u.shhpth........hspt..shhhp....ptptDh.G..lDsh.....lch.............hs......sup.............ssu.....hhls...VQlKsss..shh.........................ssssshsh..hp........spclsahhp..pslPl..lLV...lhssssp................psY...............Whplpspshp....................sppphplplshpp..hsstshpplhp.h..sh.......................................	0	24	59	79
+14123	PF14281	PDDEXK_4		PD-(D/E)XK nuclease superfamily	Bateman A	agb	Jackhmmer:B1XMR1	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily.	21.80	21.80	21.80	21.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.33	0.71	-4.42	92	355	2012-10-11 20:44:47	2011-05-24 16:36:41	1	7	324	0	99	367	61	175.10	18	46.51	CHANGED	hNlFplhph..........EhtpSshluaLLsPp...ts.........HshsshFlctal.chhttptt..p...................................hpshpVp+E...............ttp..+lD..lhl......pssph....hllIENKlh.....up-pp....................s....QLpcYhp.....hlppch..................................tttphhhlaL............psssppshss..............................t.tahtlsa.......pplhpaLcphhpp.......tttpthpthlppYhp	............................................................................shaphht.............E..pothlshhls.p......tt...........Ht....t..t..a..lphhl.chhttp....t.......................................hpphplppE...............................tttp...+lDlll..........pssph...................hllIENKlh.......up-pp........................s..........QLpcYhp.........hlppph..................................t.pphhh.laL..p..t..............ppssp.shtp...........................................tahhhsa.......tplhph.lpphhp.....................h.....................................................................................................	2	34	64	86
+14124	PF14282	FlxA		FlxA-like protein	Eberhardt R	re3	Jackhmmer:B0PBA7	Family	This family includes FlxA from E. coli, Swiss:P77609. The expression of FlxA is regulated by the FliA sigma factor, a transcription factor specific for class 3 flagellar operons. However FlxA is not required for flagellar function or formation [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-11.15	0.72	-4.09	18	424	2011-05-25 07:16:36	2011-05-25 08:16:36	1	2	376	0	79	227	8	98.60	31	75.65	CHANGED	SulS..uossSoo.tsusss....supIppLppQIpsLpcpLpcLsss...psh.os-cK..p...pQpphIQsQIptLQAQIuQlQpQpupcsppp....pppsh.p.....spssss-GsNp.Pos.ssp	....................ssh......potsSsp..tStsss........supIsclspQIppLoppl.p.clss........suh.os-pK...p...cQtpLlQpQIphLpsQl.....u...QL.QpQp.A-Ktpcp........ppt..........................h.......................	0	12	40	57
+14125	PF14283	DUF4366		Domain of unknown function (DUF4366)	Eberhardt R	re3	Jackhmmer:B0P8U4	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 227 and 387 amino acids in length.	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.74	0.70	-4.92	37	374	2011-05-25 08:16:00	2011-05-25 09:16:00	1	13	188	0	39	339	46	197.90	28	65.93	CHANGED	Rhh.u.A.LsAu.l.lls.GFossAaAtGs-ssst........hssss.t......s....c.......pcstslTP-GNhsLVDDh....sst..ssKQFITlsTKuGNhFYllIDRs.sc.s.c......s.VHFLNtVDEADLhALhE-tpst..s.............................thtps.........pspst.p.........p................................cP.Ec.................c.s..shus.....lhllLllu.....l.hGG.GAh.aYF.Khh+sKpppp.s...ssDh.--.hD.hs-..........-p.pp-Dtss.s--	......................................................................................................................t....................................................t.s.h.o.spGs..h..t..hhDch.....................t....ss+QFIThpTKsGphFYllID+spp.sc......s.VahLspVsEsDLhsh..hEctptt.t................................t...phpcsst......t.psc..p.tp........tp......................c...Ec............pu..shGs...hl.ll.llls.h.suu..GAh.YY.FKlhKs.Kpc.pp.t.....cpD.h.-p..h-...s-.....p......-p.-pp-t.t.t..pp............................................	0	25	36	39
+14126	PF14284	PcfJ		PcfJ-like protein	Eberhardt R	re3	Jackhmmer:B0P892	Family	The PcfJ-like protein family includes the E. faecalis PcfJ protein Swiss:Q5G3N2, which is functionally uncharacterised.  It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	25.00	25.00	25.00	25.00	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.01	0.71	-4.76	32	550	2011-05-25 10:31:24	2011-05-25 11:31:24	1	2	378	0	44	395	28	152.40	26	36.54	CHANGED	hWpDYlchhcchtp.Dlp..ssthlpPpsL+ttHDchhtchpthpcccctpchpc+hhc.pthh.c.lKt.+a.....pFoDsplhlpVhcSlp-hhpEGpsLHHCVs...s.ptYh...t+tcohIh.hRhcsc.hE...TlEl..p.csh..VlQsRGhpNp.....sschp-cIhphlpp.tphIppRh	...................................................................................a.Dhlphh..h...t...hp..p.....hhP...s..h..tHD.h.t..php..p...........p.p.p.tp...........p.....ch..p....................hp....h.................hp.s.th.....hhs.cohpEhhpEGpthp.HCVu............u..p.Yh....tptco.hIhShR.h..p.s..p..h..c........TlEl.........s....ps......h....plsQh+GhpNc.....p..p.chtccllsllpp..t.h.....................................	0	18	35	42
+14127	PF14285	DUF4367		Domain of unknown function (DUF4367)	Eberhardt R	re3	Jackhmmer:B0PHJ7	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 229 and 435 amino acids in length.	25.00	25.00	25.10	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.12	0.71	-4.93	52	440	2011-05-25 12:10:07	2011-05-25 13:10:07	1	11	247	0	86	388	10	174.10	15	56.36	CHANGED	hhp.+htshhhsshlh...hhss.........sh..ssp..Ahpttlh..p.hl.hphhs...phsphphpspptp............................c.....phthp..hp.s.......YlP...cGaphp..........p....hp...hss...t....hp.....hh..haps...sss.phhpa.pppth..p...s....tsh.sh...ssE....ss....ph..cplpl..s.G.......hp.uhh.hc..p.ps.........pph.......lhWpppshha...pl..t.......us.ls.......p-EllKlscsl	.......................................................................................................................................h..........hh.h...................h...........t.....hh..t...h......t...............h.hp.stt................................................................................tpht..t.htht..hhtss.hlP...c.G.hphp.....................................s..............hps...s.........hp...........hh..haps....p.pt..thhhh.t.tth...s....p..........tss..sh.ssp.....ts.......ph..cphpl...s.G........pc.uhl...hp....pps.............pts............lha..pppshhh...pl..t........usls...........c--hlclscol....................	0	50	74	77
+14128	PF14286	DHHW		DHHW protein	Eberhardt R	re3	Jackhmmer:B0P7B6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 404 amino acids in length. There is a conserved DHHW motif.	25.00	25.00	25.40	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.30	0.70	-5.14	8	368	2011-05-25 12:28:32	2011-05-25 13:28:32	1	3	220	0	48	338	15	202.40	15	68.82	CHANGED	EKRcLAcFPsFShpuhhDGSYFcDlupWYuDTaPhRDtFluhsAshcpLYGlch.sssclhussstptpDts.-sspsssspsh.s..sssspsso..........................sSsspsuospsss.sps.ps..sDsss.pshh-t.........shhpsphtsslalhsspuapLYsFsp-sucpYAuhlNshspcLs.sls.VYDMllPTuhslhLP-s.hpc.h.sousQcpAIsYhYuhhscsVKpVslY-pLtsHs-EYIYFRTDHHWTALGAYYAYpsFscstGlsshsLScacKc-hssFlGSaYutTpps.uLcpNPDTlpAYlPhsTNshchhss-us..pachlh.s.s..casuuspYSsFlGGDsslscIpNPslpDGSsllVlKESYGNAFlPFLV-HYppVYVl	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.h.t..........t.h...t........lph............t.....h.....t.......t.....t.c......l...Ya+TDHHWs..G.....A.......ahuap..........hh..........p....t......h.......t............p.............t........p.........p....h..p.........................t......t..h........hGs........h.tt...........h......t..-...h.....h.h........t.............t.......h.........................p................................t..........h....h......p...........t.........ts...Y.t...h.ah.ts.s..s.h..l...ps.....t..........s...........t.....p..hllh+DSausshhshhh..atph............................................................................................................	0	32	45	46
+14129	PF14287	DUF4368		Domain of unknown function (DUF4368)	Eberhardt R	re3	Jackhmmer:B0PC15	Family	This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00239 and Pfam:PF07508. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	25.00	25.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.09	0.72	-4.16	35	694	2011-05-25 13:00:02	2011-05-25 14:00:02	1	13	232	0	54	600	82	68.50	34	13.31	CHANGED	pplsphcppptcs-+FlsllcKYsshpELTsshlsEhl-KIlVHcs-+..psu.pRpQcI-IYasalGplchPp	......................t.plsp.pppssssc+.Flpllc+YsshpELTsshlNEhI-KIlVHEt.....pc.....css..p+......pQcIEIYasFlGphp..............	0	36	50	52
+14130	PF14288	FKS1_dom1		1,3-beta-glucan synthase subunit FKS1, domain-1	Coggill P	pcc	Jackhmmer:	Family	The FKS1_dom1 domain is likely to be the 'Class I' region just N-terminal to the first set of transmembrane helices that is involved in 1,3-beta-glucan synthesis itself [1]. This family is found on proteins with family Glucan_synthase, Pfam:PF02364.	27.00	27.00	33.00	28.20	24.40	26.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.62	0.71	-4.18	84	502	2011-05-25 13:11:19	2011-05-25 14:11:19	1	19	190	0	335	501	5	109.40	43	6.37	CHANGED	pcplhplALYLLIWGEAsNlRFhPECLCaIF+...hAh-.......h.t.hps.......ht............tts-tsFLsplITPlYphl+spsh.......c............htpct..c.........HsphhsYDDlNphFW..tscsht+lths.p	.........................cclhpluLYLLlWGEAsplRFhPECLCaIF+.............hA.-....................hht..ts......h.p.............ss-tsaLspVITPlYphl+spshc.................................hctcpc......HsphhsYDDlNphFW.scsht+lsh...p.................................	0	90	208	296
+14131	PF14289	DUF4369		Domain of unknown function (DUF4369)	Eberhardt R	re3	Jackhmmer:A7UYJ0	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00578.	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.45	0.72	-4.02	232	931	2011-05-25 14:05:07	2011-05-25 15:05:07	1	13	192	0	223	886	222	108.30	20	31.00	CHANGED	hsl...su.s.....s.pp.....t.........s....aplpGplssh.......ss.....splYL..hth....ps...st...h....s.....lDSstl.p.s..G.pFsFp..s.p..h..s.p..s....phhhl...............hh.p....s............tpp.........hhs.......hhl-.sG.p.lp.lps...........st..t...p...........hp.l..sGo.tt....scphp	....................................h..hsuC...spt......t................p....aplpGplpsh.....cs..........splYLtth......ps...st....h......s................lD...ostlp..s..G..pFsFp...s.s..h...s.p...s....phhhl................ps..................tpp...................hhs.........hhl-.sG.p..lplph.............stt.p...........hpl..pGo...scth...............................................	0	117	201	223
+14132	PF14290	DUF4370		Domain of unknown function (DUF4370)	Coggill P	pcc	Jackhmmer:	Family	\N	25.00	25.00	169.20	169.00	20.40	19.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.50	0.70	-4.89	7	36	2011-05-25 14:53:12	2011-05-25 15:53:12	1	1	20	0	17	31	0	219.80	54	96.89	CHANGED	M.....c+.hhtlRslhRuAshtSup.uuh..tpttl..cpth.tpRohhsLsusu................ttlsu-hp..sshuhuhGspRhFSEDVoHhPsIpDPcl.sAFKDLMAASWsELPsullp-AKpAlSKNTDDKAGQEsLcNVFRAAEAsEEFGGlLhoL+MElDD.lGlSGENVKPLPs.htsAl+TsapRYssYL-SFGP-EsYLRKKVEhELGoKMIHLKMRCSGLGuEWGKVTlLGTSGLuGSYVEQRA	................................................h............hR..shtu.t...h...t..h....h....tshssLsps.....................thsu..t..us.uhShs.RRhFSos.pHLPsIpDP-lcsAFKDLhAsSWsELPDSlVp-AKKAlSKsTDDcAGpEALcNVFRAAEAsEEFuGl.LVoLRMtLDDLsGLoGENVtPLPsalccAl+ouYpRYhsYL-SFGP-EsYLRKKVEsELGoKMIHLKMRCSGlGuEWGKlollGTSGluGSYVE.RA....	0	2	10	14
+14133	PF14291	DUF4371		Domain of unknown function (DUF4371)	Coggill P	pcc	Jackhmmer:Q9C842	Family	\N	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.41	0.70	-4.82	19	987	2011-05-25 15:07:50	2011-05-25 16:07:50	1	37	67	0	777	904	0	167.60	21	32.17	CHANGED	-uFVspGapsa.p..c+pR..hcpHlGp.l.sSsHp.ApcKh-shhppppsIspshpppocptKtpYhsRLshSIcssRaLL+QGLsFRGHDESc-ShN+GNFlEllsalAcp.c-lp+llhpsuspsshhss.pIQ+plhpshApcspp.Ih--lGsshFulLsDESpDsspKEQhAlsLRYVDKpGp........VhERFlGlVHVp-TTSssLKsAI-uLLscasLSLpplRGQGYDGASNM+GchNG	................................................................................................................................................................................................................................................................................................................................................h....s......................................................................................h......th.h.t.hh...t..................h......h...h......................................................h...p......................p.......h.pp.l..phh.u...pt.l..h.p...lh...pp..l...p..s.....p....h...F...u.l.h.hDcstD.h.u.p.p.c.Qhsl...hlR.a.l....p.t.p.t............ltE.cF..l...shht.h...p...p...............t...............s....u..tl.hphl......p...h..l.t..p...h.sls...h......pp..hh..upsa..D...suush.s............................................	0	218	578	708
+14134	PF14292	SusE		SusE outer membrane protein	Eberhardt R	re3	Jackhmmer:A7V649	Family	This family includes the SusE outer membrane protein from Bacteroides thetaiotaomicron, Swiss:Q45769. This protein has a role in starch utilisation, but is not essential for growth on starch [1].	25.00	25.00	25.00	26.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.71	0.71	-4.29	45	304	2011-05-26 07:22:16	2011-05-26 08:22:16	1	4	133	0	53	283	22	120.30	19	29.15	CHANGED	lhhh.hhhhsuCpcDp..phtsh...psps....s.pLthsssssslsLst...us....s....A..lphsWssAshtss..s.slpYslphsttss.sFuss.lshs.psss...tpphohTspcLNs.l.h.s.p.h.Gl.tsspsssl..phclpu	...................hhshhhhsuCpc........Dt..p.ssh...p.ss.....shsLstss.s.s.spl.sLst...tss..s...u..lphsWop.s.....s......hsss.............s........s.....l..s...Y.........plp......hsh.....ts.t......sFsss..hths..pstt........ptphshottpLNp.h.h.s.......p.h....sh....tss......ptspl...hpl.........................................................	0	23	47	53
+14135	PF14293	YWFCY		YWFCY protein	Eberhardt R	re3	Jackhmmer:A7V7D7	Family	This family is found in bacteria, and is approximately 60 amino acids in length. There is a conserved YWFCY motif. It is often found in association with Pfam:PF02534.	25.00	25.00	28.40	27.40	24.00	23.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.72	0.72	-4.13	13	298	2011-05-26 09:50:59	2011-05-26 10:50:59	1	4	115	0	29	252	8	59.80	61	10.31	CHANGED	QpEDDLRALAKIMDFhRAlSIlllllplYWaCYpuh+tWGlslsVlD+ILhNFpRTuGLFu	......QQEDDLRALAKlMDFhRAlSIlhlllNlYWFCYpuhctWGlslGVlD+ILhNFpRTuGLFp...	0	13	26	29
+14136	PF14294	DUF4372		Domain of unknown function (DUF4372)	Eberhardt R	re3	Jackhmmer:A7V8G9	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF01609.  There is a single completely conserved residue G that may be functionally important.	25.00	25.00	26.40	25.00	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.26	0.72	-4.10	46	284	2011-05-26 12:17:13	2011-05-26 13:17:13	1	3	143	0	79	290	118	72.30	32	23.51	CHANGED	ppupslFuQllchls+ppFccllc+.apG-ptl+pFosasQhlsMhauQLotp-SLRDIpssLpuppsKLYHLGhpp	...........psphlFuQllphlspppF.pphVc+..apuc+asKpFosasphlsMhauQLoppcSLR-lpssLpupp.t+haHLGht.t............	0	33	60	73
+14137	PF14295	PAN_4		PAN domain	Coggill P	pcc	Jackhmmer:Q2FN86	Domain	\N	27.00	7.00	27.00	7.00	26.90	6.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.18	0.72	-4.25	64	1029	2012-10-02 11:41:37	2011-05-26 14:20:17	1	128	214	14	794	1625	53	47.50	22	13.28	CHANGED	sDh.GsDh.psh..h.......s.s.......s..psCtttCp.psspCp..uaoasp...............s........s....upCaLK	........................................ph.G.s..h..tt...h......ts.s........................s.spsCpphC........p....s........s.....s........s....Cp..hao.ass.........................t...........t......tp..CaLK...................................	0	389	539	755
+14138	PF14296	O-ag_pol_Wzy		O-antigen polysaccharide polymerase Wzy	Eberhardt R	re3	Jackhmmer:A7V9M7	Family	This family includes O-antigen polysaccharide polymerases [1]. These enzymes link O-units via a glycosidic linkage to form a long O-antigen [2]. These enzymes vary in specificity and sequence [2].	25.00	25.00	25.30	25.10	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.83	0.70	-5.90	29	375	2011-05-26 13:28:48	2011-05-26 14:28:48	1	3	336	0	31	222	10	415.20	39	91.97	CHANGED	ls.h.hha.llshhh......sshphlh...hslh..hlhlh.shlas.h.........pphphh.hhh...hFhhshFlFlhup.h.lshh.....h.s.h..........hshp.ahp.phhh..ps.....hhlhhluL...lhhalGhll...hppp..phph...pptptpp....pph...hpthphl..shhlha.lshl..th....lht.hpplhhhtssuYhuhYts..htpp......h.s......t.hhhhhu..shhhhu...hhlaL..sohss++c..hhh.hhlalhhtll..slltGpRs.hlhslLhlhhYahhpph............hlshhphhhlhlh.sshlhhh.........hshhshlRsp.............p..htt.shh.sslhcFhhsQ..........GlShtlluh.........shphp...splstpt..sYsh..hhph.h..t.l.tt.lhuh.hsh..tspshc.sh.ssshucplsY..hl.ssstYLtGhGhGoSal..AEhYhDaGhlG...lhlhshl...lGhl.l.....thhpp..hh..pps....hhh.hhh.shhhlsslhahPRushhs.l..hhhhhhhhhllhlh	.........................................................................................................hl...h.h.hhhhh..........sp...ll....slh....hl.l.ls..sllhs.h..........scl+hhhl.aa......lFhlolFlFL.lo.R..Ps.lsYF.........t.s..s...........ulc.s...Yps......shp....aA.....alllhlSl...LGlshGulL....hs++...+.lKh..tshusshc.....csa.....lKpL+hl....S.LslFl.Lsa...s..ah.......hlc.ap......cLla.p..lp.......so..Y.hAhYss...acSp................L.P.....a.FshhLS......saslhu....hshYL....uo+P..+K.hp......u.ptl.......L.ls..alssssl....pLslG.oRss.FILoILhsFlYY.ahRcp.........+........tKaIuhKcplsIalu.usILhl.u.........MGl..l.sYlR-ss.................p..loas.uhh..-lllDFlYcQ...............G.sSau...V...Lup.........uhhas....spLPhcc...NaTaGsll-a.Fspus.L.us.IFus..pu.h....hsssSl-lulcuNSaAHsLSY...ll.lsc.cY.L.pGa..GlG...SS.....Y...I..hE....lYs.DaG..hlG....VFL.lSF.L...LGlL.l.....uhLps.....sh.....+..s+....sIl...hsl...uL.llL..ssLF.F..hP..RuSFop.sahsLhshpFhslllllh........................................	0	12	22	27
+14139	PF14297	DUF4373		Domain of unknown function (DUF4373)	Eberhardt R	re3	Jackhmmer:A7V2U9	Family	This domain is found in bacteria, eukaryotes and viruses, and is approximately 90 amino acids in length.	25.00	25.00	25.70	25.50	23.40	24.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.77	0.72	-3.69	44	354	2011-05-26 15:13:09	2011-05-26 16:13:09	1	4	157	0	42	290	6	91.60	23	32.64	CHANGED	YFsh-sshhpDpplphlht+.h.G.hcGhuhhhhllpplhp.pssY..hsshpt...h.......ph.hApch..s..hst..........splcpllp......-a...sLF...s...hpp....p..t..hpS..t..lp	.........YFshssshhpDtclctlttc.a.G.hpGhulhhhlLsp.l.Yc.psta..hh.hcp....h........hhlupph...s..hst...................ctlppllp......ch...sLFs...hpp......p..t.lloSttl............................................	0	14	33	41
+14140	PF14298	DUF4374		Domain of unknown function (DUF4374)	Eberhardt R	re3	Jackhmmer:A7VA08	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 406 and 466 amino acids in length.	25.00	25.00	27.00	25.50	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.65	0.70	-5.90	8	125	2011-05-26 15:24:25	2011-05-26 16:24:25	1	2	81	0	32	115	0	283.90	23	80.97	CHANGED	oSCoDs-s..P.....usus..ssssKusYVIAuosssSsussshLLTAESLDEGolSolsNGL.ssDGuT.WVFYcspYLYuLsYNQGsAGTTpSYILsuNsclcpRstoYslpRFTTYGIYscaIlTsSTGDGspEhsDpNGYlPpuFLlSYLDVscpThTTNs.ppppshLuENFLGNGEaVTLAGIlEsNsKlYouAIPMGLSpYGsp..s-sGt..hlLssspDLVKTEsGGSGSGuYcKGEL.WTQYPNcsaVAIasssoFsscKlI.cTDKISYACGRhRSQYYQTIWuADNGDlYVFSPSYAKTM........oDt+QQT.TLPAGVVRIcAGuE-FDssYYsNLEppouG..+uFlRCWHIosDYFLLLMYD+.....s....lTt.TuhsAsELAlFKAEspKLTYV.oGLP..Ss.lISGFGNTPYsENGhAYhAV.TTT-G.pPAlYKIDPsoAoATKGloVE	.................................................................................................................t..........................................................................................................................................................................................................................................................................................s.asspsalAlas...........shp.p.ll.pss.+hu..hhsuh..h..h.hp.tlh.hs-sGD.lYlF.S.suhsth...........ts..t.o.phPuuhhRIptut......p-FD.sYahshpt.sss.....t.....hhphhalsts.h.Fll.hh.sp...s..........hst...ps.....hsspp.h..u.l..h..cs....t.stp.hh.l.pGlP...st......s...s...h.u..t...t...s..h...s.-..p..G...h...sYhsl..ssp...pG......s.h......lYplDstsupAs+Ghpl..........................................................................	0	10	31	32
+14141	PF14299	PP2		Phloem protein 2	Coggill P	pcc	Jackhmmer:Q9C8U9	Family	Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances [1].	25.00	25.00	26.70	25.50	24.00	24.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.04	0.71	-4.83	88	511	2011-05-26 16:48:35	2011-05-26 17:48:35	1	14	50	0	261	487	0	150.10	27	61.38	CHANGED	Gt+CaMLSARs.LsIsWu-s...sp.YWpWhsh..............spSRFtEVAcLhsV.sWLEIpG+lssphLSPsTpYusYhlh+l.............s-p..saG......h-..h..Pl...............c.h.....slsh.....................................................s..ss.............................................p.p..p.....................p.p.php...........h..p..............................................cRs......DGWhEl.-lGEFh....s.s..p.....s.....pss....ElchSlhEsc...ssph..KsGLllcGIEIRPK	..........................................................t.shhlsu+.s.Ls.I..sh....hs...s....p..YWpahsh..............spu..ca........clA.L.pl..hW....l.-lpGplphph..h...ssspYsshhhhph.....................tcp...shG......hc..h....sh................p...hplsh...............................................................................s...st.................................................................p.p.........................t..tthph..p..............................................ptt......-.sWhEh.chG.-Fh....sp....p.........t.........pss.....clp.hsh..h-h.c...ssph..KsGLhlcGl.tIpP.........................................	0	40	141	190
+14142	PF14300	DUF4375		Domain of unknown function (DUF4375)	Eberhardt R	re3	Jackhmmer:A7VAK3	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 156 and 204 amino acids in length. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	25.20	25.30	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.57	0.71	-4.13	41	346	2011-05-27 08:18:22	2011-05-27 09:18:22	1	4	298	2	55	291	11	119.00	25	63.69	CHANGED	-.shppLss-Q+sLlAhphLcpEVpsGGFsQhhtNuhGtalh.pshhcuh+paGhcchscllpcupplYtpp.t.sl-c-pp..tcph.shh.cp.....a..st.....F--hDcpah..-hEE..phsphlspYlcpHh-pF	.......................ht.Lsscp+pLhAhphhcu-VtsGGFsQhltN.uhG..th.l..h.pshs....cuL+phGspchspllc+At.s..l...a..pppttsl-pp.tp...tp......ch.shh..cp.........h..tp.....h-ph.Dctaa..-ht-...phhthl.stalptp.t.F...........................................	0	24	34	43
+14143	PF14301	DUF4376		Domain of unknown function (DUF4376)	Eberhardt R	re3	Jackhmmer:A7UZK5	Family	This domain family is found in bacteria and viruses, and is approximately 110 amino acids in length.	25.00	25.00	25.20	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.34	0.72	-3.94	46	601	2011-05-27 09:01:56	2011-05-27 10:01:56	1	7	328	0	48	539	8	107.00	30	60.69	CHANGED	L-ps+stKhsEIsshRsptpss..u..hshp..u.tchtsspps..p........hp...hssslt.....h.upps.shs.tsh.....hWpssssts..lshs.......hh..shttslhp..p...sp..phapcppph+pplpuhpshcslpuh	...................Lcts+pt+hp..EIpshRspppst.s..hsac.....s..tph.s..ssss...p............hp...l.sslh........h..Apss..sh...sth..............hW.sD.....uDNpp....V.p.loh....-hht....sh.spuhss..+...spcIap+pcphKpclps..hsshpplps.................	0	8	29	41
+14144	PF14302	DUF4377		Domain of unknown function (DUF4377)	Eberhardt R	re3	Jackhmmer:A7V378	Family	This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	25.00	25.00	25.40	25.20	23.30	17.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.49	0.72	-4.08	59	285	2011-05-27 09:46:05	2011-05-27 10:46:05	1	11	240	0	66	282	16	80.30	31	37.50	CHANGED	lhVsspp..ssC..s........Gh.....hshpChtV+pp...spp..........sWp.haYssIcGF..s..a-sGacYtL+V+c..hpltss.....PADuush.pYpLlcllpKp	.......................................Vuspp...ssC...s........Gh.....sshpCLpVRcs...tts..........sWp.haa..us..IEGF..s..acsGhcYhLcVpc..hphtNP.....PADu.uu.h.tasL.pllpp.........................	0	15	38	53
+14145	PF14303	NAM-associated		No apical meristem-associated C-terminal domain	Coggill P	pcc	Jackhmmer:Q9SKG8	Family	This domain is found in a number of different types of plant proteins including NAM-like proteins.	27.00	27.00	27.10	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.40	0.71	-3.90	48	509	2011-05-27 10:45:57	2011-05-27 11:45:57	1	15	25	0	377	488	0	144.70	18	46.12	CHANGED	+sFshhHCWplL.+spsKWpsch.p........................t.pp.ppt..........psssps....sssss...pts..sss....sp....ssstp........................................cRP.GpKpuKpthp..........................th.c..................................c.tp.........................cc+ht...p..p.......hppt....p......cc+h..........p.................hccc+h-hcphp....pEccIMhsDhosl.ss.pppa...hcthpccI	..................................................................................................Fph.asWplL.+ppsKWpsh.tp..........................pp.pt..........................tstspp...sstss......sts..sss......sp.......ss..ttt.......................................................................pRPhGpKtAK.pphppt........................h....th.............................................................t...........................ppcht..p......thtp.....p............ppph........p.................hppcp..hphp.h...........t..plh.hDhssh.s...................................................................................................................................	0	143	254	311
+14146	PF14304	CSTF_C		Transcription termination and cleavage factor C-terminal	Coggill P	pcc	Jackhmmer:Q8VYM7	Domain	The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.	23.00	23.00	23.00	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.16	0.72	-4.68	4	329	2011-05-27 10:51:39	2011-05-27 11:51:39	1	13	212	1	210	290	1	43.80	49	10.15	CHANGED	spp.tupAtLl.QVhpLopspIshLPPtcRppIh.LRpQlp+ut.sp	.............cpsALlhQVLQLos-QIuhLPPEQRpsIlhL+pQltps...th.....	0	56	96	153
+14147	PF14305	ATPgrasp_TupA	Glycos_tran_Wfd;	TupA-like ATPgrasp	Eberhardt R, Iyer LM, Abhiman S, Burroughs AM, Aravind L	re3	Manual	Family	A member of the ATP-grasp fold predicted to be involved in the  biosynthesis of cell surface polysaccharides such as the O-antigen  in proteobacteria, the capsule in firmicutes and the polyglutamate chain of teichuronopeptide [1]. 	25.00	25.00	25.80	25.10	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.53	0.70	-5.06	14	355	2012-10-10 13:17:03	2011-05-27 14:24:01	1	11	269	0	99	342	80	230.60	28	73.88	CHANGED	pKlQahKlh...scs.hhshhsDKhpl+calpcphGpp.hlIPhluVhsph...psIcapplP.ppaVlKssHsSG..shhlspscsphshhpsp.....pch.pphLpp....shhhhsREa.Ypplp.+lIlEchhtcpss........cDYKhaCFpGpsphl.lplcR..psppptshashsaphlsh...stpa......stpphpKPsshc-hlplu....cpLSpc..hPaVRlDhYpsssplYFGElTFh...suuGht.chhPc-aDchlGchhp	......................................pKl.ahh..h......ppshhsphsDKhtVRc....altpph.s....p....p....hllPhl.s.hhssh.....p-ls..a..spLP....ppFVlKssHsoG.......sshls...pDK.sph..s.hp.pht.....................pph.pphLpp.................sahh..hs+Eh.p.Y+slps.+.Il.sEchlt....sp.s.s.....................tD.Y.....KhasF...s...G.....c....s.....p..hl..l...sh.s.R.........tsp.p.p....h..s...ha.D....h.s.W.phhsh......p.phs.........stp..h.s..+..Pp.ph....cchlplA....cpLups......hs.a.V.RVDhY.t.s....ss........c.lYFGElTFt...ssuG..h....ph....hspp....hDhhhGphh...........................................................................................	0	37	55	77
+14148	PF14306	PUA_2		PUA-like domain	Bateman A	agb	Bateman A	Domain	This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes.	27.00	27.00	27.10	27.10	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.81	0.71	-4.83	89	1267	2012-10-02 17:37:24	2011-05-27 16:48:36	1	16	994	50	512	1155	428	155.00	30	31.10	CHANGED	ltPHG..G.....pLh........shllpsp.ptpphhpcutp...L.Pp..lplospph...........sDLphlutGsFSPLpGFMscpDYpuVl-ph+L.s.............s........Ghh...WolPIsLsVsp-ptpp..lptGscluLppt...Gph.lAllp.lp-hYph...-KppEAppVatTs-..t............HPGV.phlh...ppschhluGslpllpp	.....................................lhphhs.tt...phpt.hhtc..App.....h...p.lplsphpl....................................s-LpllupGhaSPLpGFMscc-Ypp...Vl.cph..+L..s.........................s...........................Gsl.......aolPIsL....s....ls....cc....ptpp...................lc....s....G...s....c.lsLhtp........Gph..lAllp.l.p-hap....cKpc...cstplauTss..t.............HPuVp......hlh...ptGchhlGGslpllp.....................................	0	175	312	427
+14149	PF14307	Glyco_tran_WbsX		Glycosyltransferase WbsX	Eberhardt R	re3	Jackhmmer:A7V083	Family	Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases [1,2].	26.10	26.10	27.00	26.40	24.70	26.00	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.38	0.70	-5.28	84	380	2011-05-31 07:37:58	2011-05-31 08:37:58	1	33	282	0	99	359	61	323.30	31	59.13	CHANGED	+lIAaYLPQFHPl.P.E.NDcWWG+GFTEWTNVs+A+PhFcGHYQP+..lPs.-.LGaYDLR.s-shctQAcLA+caGIpGFCaYHYWF.sG......K+lLE+Ph.cp.lL.p.ssc.DhPFCLsWANEsW.o+.pWcG...t....spcl....LlpQpYssccD..ppHh....phll..hF+DpRYI+l-G.KPlahIY+P.......ppl.PchpphlphWcph.Ap.csGlsslahlsht.......................tth.tt......p......hphGaDussph....t..........stt......h.tth..................s....htt.......thtph...hppt............h....th....sph.h..........c.Ys..phhpphls.p..t.t.....p....h..phaPslhPsWDNosR..........+sp.p.uhl.hhsuoPctFcpaLppsl.p.p.sp.p.p.......pcchlFINAWNEWAEGsaLEPDh+aGhuYLcAl	......................................................................................................................................................................................hlAaYLPQaHsh...E....ND....tWWGcGFTEWsNlt.pAp..PhFpGHhQP+..hPh.p.hGaY..DLp.sc..shptQsclA+phGltGFsaaaYWF..sG...........+pl....LE.pPh...pp.hL.....p.st..c.D.hPFClsWANcsW.s+pWsu.............t.....ppcl...............LhtQpYs.st.pD.....htpah....phlh.thFpDpRY.l+l-.....G..+.Pl.hhlYcP..............ttl...schpphlphWc.ph.sp.c.tG.h.sslahhtht.................................sth.t.........p..........tphu....a....Dushph...tshh.h..ht................................h.t.......ph..hp.h.hppt...................h...........hph..h..........cYp..chhp...t.hhpp...p...t..........s.....hphaP.s.lhs..sW.DNo..sR..............ptt..p.uh....l.....h..hs.uoP.cta..ppalppt.hp.h.st..p.p........ppch..lFlsAWNEWuEGsaLEP.Dh.+.aGhuaLcsh.................................................................	0	40	76	89
+14150	PF14308	DnaJ-X		X-domain of DnaJ-containing	Coggill P	pcc	Jackhmmer:Q93ZH5	Domain	IN certain plant and yeast proteins, the DnaJ-1 proteins have a three-domain structure.  The x-domain lies between the N-terminal DnaJ and the C-terminal Z domains. The exact function is not known.	27.00	27.00	27.80	27.50	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.16	0.71	-5.05	53	402	2011-05-31 12:29:53	2011-05-31 13:29:53	1	12	193	0	305	409	4	194.00	27	43.07	CHANGED	ptpccRlpcLuppLhc+lp.as........c..ssp........cp.........Fpp+.hppEsc.sL+hESFGl-lLHsIGtlYppcAspaLtppp......pahG.lut...........haspl+.sKGcsh...Kssa.......sslsoAlcAppsh-p.hp+.......hpppt...................s.c..h....spcc.....hschpcp...htu.............K......hLsshWphs+aEIpssL+cVCpplLpDcsV..spcpRhpRAcALhhlGchFppsccs.s..c...-pppt.psFEc.lhs	........................................................................h..ppcR.ppLuppLhc+lp.as......................c..ssp..............cp............Fppp.hc.Es........c.pL.phpSFGh-.....lLcsIGhsYhppAsphL.ppp..........ta.hG.lst...........hhp.th+...s.Kuphh....+sph..........ssh.ssAlsh.phhcc.ht+.......h.pppt...............................................................................................t.p.......spcc............htchtcp.hts..........................................................................p......hLsuhWphshh-IpssL+cVCpplL.....p.D..p.sl.......s.p..cphhtRAcALhhlGplappstps..p...cttt..................................................	0	122	199	273
+14151	PF14309	DUF4378		Domain of unknown function (DUF4378)	Coggill P	pcc	Jackhmmer:Q9FIS0	Family	\N	25.70	25.70	26.00	26.20	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.02	0.71	-4.18	103	449	2011-05-31 13:05:52	2011-05-31 14:05:52	1	9	28	0	299	412	0	156.50	19	19.00	CHANGED	p-...hpYlp-lL.tsuGl.h.pst.t............h.....p..h..psssp..PlsPslFcpLEppt.........s..................................ttsptt+.scR+LLFDhlNEsL.......s.......chht........hshpshhp.....th......shphp.........h...su..pp.Llc-lhpplpphht.......ps....h.pp...p.....t........ll..scD.hspp.....tt....hh.....shpp......-sppluh-lEchlhc-LlcE	.............................................................hpYlpclL..sush.htp................h...........t.h..h.ssp..slssplFpplEpphs...................................t.tttpp.c++LLFDhlNEsL.............s..chht.........hshtshhp.......htht.h............h.....ss...pp...Llcclhp.plpphht...............ppt.....h.pp.....p.....t.........ll...tcD.htpt.........tt..hh.....shpt......-hpplsh-lEchlhc-Ll-E..................	0	50	182	249
+14152	PF14310	Fn3-like		Fibronectin type III-like domain	Eberhardt R	re3	Jackhmmer:A7VAA0	Family	This domain has a fibronectin type III-like structure [1]. It is often found in association with Pfam:PF00933 and Pfam:PF01915. Its function is unknown.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.23	0.72	-4.04	1123	4829	2011-05-31 13:39:53	2011-05-31 14:39:53	1	85	1882	11	1761	4491	425	70.70	32	9.16	CHANGED	EVVQ...LYl..p......s...s..s......u.........s......l..s..cP.s..+pL+GFpKl.p.Lps.GEoppVsh.s.ls.t....c.s....luhac.t.......p...t....p..........ahl-...s......Gp..aplhl..Gs..SS	...................EVVQ...lYl.p........s..s.s.........u...............................s......h....s..cP....s....+pL+GFcKlp..Lp........P....G........E.oppVsh.s.ls.h....c.s......L.uhast........p...t....p.................asl-...s..........Gp...aplhlGssS...........................................	0	582	1136	1550
+14153	PF14311	DUF4379		Domain of unknown function (DUF4379)	Eberhardt R	re3	Jackhmmer:Q7UL48	Family	This domain is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. It contains a CXXCXH motif and a CPXC motif.	24.50	24.50	24.70	24.50	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.21	0.72	-4.15	113	571	2011-06-01 07:26:03	2011-06-01 08:26:03	1	19	105	0	218	533	412	55.50	29	36.58	CHANGED	scLspEas.....csp.....hpPspVshuSph+shW+Ct..pC.uH.cWcAplssR.o.....spssGCPtC	...............................clhpEWs....tcNt........hsPpp..lsh.s.S..p...pcs..a..W.cCs.........ps.uH..pWpuplpsRs........tpspsCPhC.....................	0	153	193	213
+14154	PF14312	FG-GAP_2		FG-GAP repeat	Eberhardt R	re3	Jackhmmer:Q7UNP1	Family	\N	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.48	0.72	-3.95	180	1055	2012-10-05 17:30:43	2011-06-01 10:35:36	1	62	110	0	582	1179	1780	50.20	34	23.05	CHANGED	asppsKLsA.oDGuusDhF.G..hSVulsus..s.hlVGAh...t-Ds...ts......s.GuAY.lF	.................tthlhu..s....s.....s...s...s..sD...t....F.G....h.S...Vul..su-..........s..llVGA.................t--s................sus...............s.u..GusYlF.........................	0	432	550	571
+14155	PF14313	Soyouz_module		N-terminal region of Paramyxovirinae phosphoprotein (P)	Coggill P	pcc	Karlin D	Domain	The soyouz module moiety is the N-terminal region of the phosphoprotein (P) from the subfamily Paramyxovirinae of the family Paramyxoviridae viruses. The main genera in this subfamily include the Rubulaviruses, avulaviruses, respiroviruses, henipaviruses, and morbilliviruses, all of which are enveloped viruses with a non-segmented, negative, single-stranded RNA genome encapsidated by the nucleoprotein (N) within a helical nucleocapsid.	21.30	21.30	21.30	21.30	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.66	0.72	-4.41	16	410	2011-06-01 10:13:34	2011-06-01 11:13:34	1	9	40	3	0	415	0	56.90	54	14.64	CHANGED	MshhsDsEIscLl-pusslI-pIppupspssc..ThG+SsIstGsTcsLssAWEccsssp	...MATFTDAEI--LhETSGTVIDSIITAQGKssE..TVGRSAIPQGKTKALSsAWEKHGs.............	0	0	0	0
+14156	PF14314	Methyltrans_Mon		Virus-capping methyltransferase	Karlin D, Coggill P	pcc	Pfam-B_840	Family	This is the methyltransferase region of the Mononegavirales single-stranded RNA viral RNA polymerase enzymes. This region is involved in the mRNA-capping of the virion particles.	20.20	20.20	20.30	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	675	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-13.08	0.70	-6.68	10	144	2012-10-10 17:06:42	2011-06-01 13:38:09	1	2	69	0	0	167	31	660.80	50	31.64	CHANGED	l+.p-G-W-sLossEKSYHVGRslGFLYGDLshp+Ssps-DSSLFPLSIptKlcGRGFLRGLlDGllRuSulQllHRRolspLK+PtsAlaGulhYLI-KlossssFhsLlRcGPIR-ElpoIPHKIPoSYPToppDhGtllRsYLKpph+plccupYposhss.lWlFSDltSpc..alGshulSoplLchLhcssLSK+s+spLRcLusLppplRoscs..h..s-hclcplhpchL....hCspElRHAsKF..shsKpssspthh.......WG.pEhhGslpplPV.Yoossss....chhphs.PRlQNPLISGLRlsQlATGAHYKlRoILsshcIpacDsLssGDGSGGhTuslLRhNspSRuIFNSLL-lsGpsh+GopPsPPSAL.slGs-.psRCVNt-osWEcPSDLScppTWcYFhcLKpphuhpIDLIVhDMEVpD.phsppIEppl+calhpLL-csGsLIaKTYGThlsspsps.slshLGshFcoVpLlQTphSSShTSEVYllh++h+phl.DssalDasoL..pchhpplasFps.+pEFcRA+plpppchlhGlPsplIPDPhV-LpTlLpIuGVsSGluHplsp-lppupush.phAlllsslIsa.p.shslo+hhs.p..phpPPSDucll+hhsslsGlshWLSltppDlshapphppllscsh.sI+atptht+.uphhhpW	.................................................................................................IcL+sGDaEoLoscEKShHIGoAQGLLYSILVAhHDSGYNDuoIFPVNIYuKVSPRsYLRGLARGlLIGSSICFLTRMTNINIsRPLELISGVISYILLRLDNHPSLYlMLREPsLRuEIFSIPQKIPAAYPTTM+EGNRSlLCYLQ+VLR....YE....R-sl...os...SP-sDhLWIFSDFRSsKMTYLoLlTaQSHLLLQ+l.-+sLSKpMRspL...RQhuSLMRQVLGGHGE.sh....-SD--IppLL+DuLp+.........T+WV.DQEVRHAA+o..Mpuc.h.S..P..s.c.+.hSRK......hGsSEWlCSAQQlAVSTSu.NPAPhS-hDlRsLS....+RhQNPLISGLRVVQWATGAHYKLKPILc-LslaP.sLs.LVlGDGSGGISRAVLsMFPDu+LVFNSLLE...VsDLMASG.THPLPPSAIhoGG-DIhSRVIDa-SIWEKPSDLRN.sTW+YFpSVQcplNMoaDLIICDA.......E..V.......TDIu.Sl.N+.......IsLLhS.......DFuh..SI.-.GP.lhLlFKTYGThLlNs.-Y+.Alp.HLSRAFPoVsGalTQhTSSFSSElYL+FSKpGKFF.RDuEaLTuSTL...REMSLV.LFNCSSsKSEhpRARSLN.YQDLlRGFPcEIISNPYNEMIITLIDu-VESFLVHKhVDDLEL...p+GsLSKhuIIlsIhIlFSNcVFNloKsLs.-P.hFaPPSDPKlLRaFsIpsuThhaLSsshGDlssFs+LH-LYNpPl..oaYFc+Qsl+.GphalsW............................................	0	0	0	0
+14157	PF14315	DUF4380		Domain of unknown function (DUF4380)	Eberhardt R	re3	Jackhmmer:Q7UYS3	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 288 and 372 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.	26.50	26.50	26.90	27.00	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.73	0.70	-5.22	21	128	2011-06-01 12:55:25	2011-06-01 13:55:25	1	2	114	0	49	125	11	260.80	25	81.04	CHANGED	tua.pslpLuNsslclslTsslGsRIlta.uhpG.upNlL............s.htsthttsstschhhhuGpRlWhuPE.........t..+p.....a.PD....ssshphp......ppsltlpssssshoGlphphplplsssp.splplppshp......Ntstt.slphshWshThlss.uGhshhPlsstsph.........pl.hhshophtps.phphpcchlslpssstst......tKlGhsspsGWhAh.htpsplFlcpashhs.sA..pY.P-hGhshEh..Yss.......pshlEhEshuPhtpLpPGpshpapEpWpLhc	...................................................h.pslplssshlclhlssshGsRllpa..uhps..ttNhh...................tt.hh.ss..tsphhhhGGc.+lWh.....uPp...........................................cp......a.PD....s...tshphph......pssl..tlppssp......t.h..sslphphpl........p....h.pss.............p...spl..plptplp...................Nhssh.....sl.....p.....huhWslohls..........s..s.......uh..hlPhs..stss....................pl..hhshs.phts..Rhhhscphlhlctssp.ps.........hKlGhss..p..tG..W...hAh....hs..sspla..lcpath.....su..tY.P-h.........G.phEs..Yhs......................shhlEhEshuPhhpLpPGpphpa.E.WpLh.................................................................................	0	27	42	45
+14158	PF14316	DUF4381		Domain of unknown function (DUF4381)	Eberhardt R	re3	Jackhmmer:Q7ULH4	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 158 and 180 amino acids in length.	27.00	27.00	27.10	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.19	0.71	-4.09	111	458	2012-10-09 19:59:19	2011-06-01 14:55:13	1	4	391	0	131	402	66	145.10	27	87.80	CHANGED	sLtpLpDltlPsslu.aWP.A.GWWllhsl...llhhlh..hhhhh....hh.++ppp.p....t..h++t..ALptLsplpt..............sssphhsplspLLK+sAlshh...P+p..plA.sLsGpsWhpaLcspts..........hssthtp..tLhp....thYpstst...............hpp..lhptsppWlcpp	...............LtpLpslhlP.pssu..WaP.A.GWWlllsh...llhslh....hhhhh...........hhp+tpp....p.............t....h++p..ALptLsph.............................sssphhpplstLL+csAlsha....P+p...thA.sLs.GcsWhsFLDspss..............t..hsshtp.....hhhpshYpspsh............ps......hspLhptsppWlcp...............................................	0	28	57	95
+14159	PF14317	YcxB		YcxB-like protein	Eberhardt R	re3	Jackhmmer:Q7UN84	Family	The YcxB-like protein family includes the B. subtilis YcxB protein Swiss:Q08793, which is a functionally uncharacterised transmembrane protein.  This family of proteins is found in bacteria, and is approximately 60 amino acids in length.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.92	0.72	-4.72	258	600	2011-06-01 13:57:44	2011-06-01 14:57:44	1	4	461	0	124	522	35	62.50	16	34.41	CHANGED	l..sccslth.....ps....spspsph...pWsplpp.lhcscphhhl....hh.......spt.phhhl...P+.c.shs........ttph.....pphhphlp	........................hpppulhh......ps....tpspsph...tWspltc.lhcscphhhl....hh.........spt.pshll...PK.c..shs....ttph....pphhth......................	0	41	86	104
+14160	PF14318	Mononeg_mRNAcap		Mononegavirales mRNA-capping region V	Karlin D, Coggill P	pcc	[1]	Domain	This V domain of L RNA-polymerase carries a new motif, GxxTx(n)HR, that is essential for mRNA cap formation. Nonsegmented negative-sense (NNS) RNA viruses, Mononegavirales, cap their mRNA by an unconventional mechanism. Specifically, 5'-monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate between the large polymerase protein L and mRNA. The V region is essential for this process [1].	21.70	21.70	22.00	41.60	18.00	21.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.57	0.70	-5.34	63	729	2011-06-01 14:32:24	2011-06-01 15:32:24	1	9	223	0	2	766	0	237.80	32	11.27	CHANGED	sCSsslActLRphSW.....GRplhGlTsPcPlEhhss..hh.ttp.Ct...................Cp..t..sppp.....hohhh...hss...lspstp.spu.tsPYlGSpTpE+p...hhphhphcstsshlKpAl+ltsshpWhhssssp.hpphhplhpstssl...shsphphl.sh.poushtHRhssupsppthhsus.sthsoahphosDshphhsct....pshslhaQp...llshuhhpshhth.pssshpstshHhHhpsssCl+clpps	...........CSsplAchLRppSW....tGRpIlGlosPcslEhhcs.tllpsotsCsh........................Cp..s..Gspp.....hohhh...lPuthplsssspts.u.+lPYlGSpTpE+p...shphhphtsho.plKsAl+ltsshtW..saucs-.sphpthhplupu+ssl.....oh-.l+hl.Ph.pouNlhHRLcDutsphpassushsplusalplSsDshshhtp-..tsp-tNllaQp.hh.LhGLulhcohh.hppspshsp.hslHLHhchssCl+.h.............	0	2	2	2
+14161	PF14319	Zn_Tnp_IS91		Transposase zinc-binding domain	Eberhardt R	re3	Jackhmmer:Q7UXQ4	Family	This domain is likely to be a zinc-binding domain. It is found at the N-terminus of transposases belonging to the IS91 family.	25.00	25.00	25.00	25.30	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.33	0.72	-10.87	0.72	-4.56	72	995	2011-06-01 15:28:09	2011-06-01 16:28:09	1	9	449	0	150	849	144	105.20	32	30.65	CHANGED	t-Ihcp...ahssa...p...p.pa....sttls.spt+shpuIhpCRT.sshGsphhpCps..Csppc.hhhpSC+sR.aCPpCQspssppWlppppsclLP.ssYFHl.VFTlPtpLpslshp.spchlYs	........................h..lhpt...hhs.h........p.t.......tttltsh.hcshschhtCGo.thhGh.pphpC..ss...Cs+p+.hlshS.C+sR.tCPpCGs+tsspWlthhhscl..s.ssahHl.VFTlPpplhslhhpsp..h..h...........	0	56	94	121
+14162	PF14320	Paramyxo_PCT		Phosphoprotein P region PCT disordered	Karlin D, Coggill P	pcc	Jackhmmer:Q4VCP9	Domain	The N-terminal half of the phosphoprotein P of the Paramyxovirinae viruses.  The very first 60 residues have been built as the family Soyouz-module, Pfam:PF14313. The remaining part of the region, here, is disordered, and is liable to induced folding under the right physiological conditions. The region undergoes an unstructured-to-structured transition upon binding to Measles virus tail, C, unstructured region.	27.00	27.00	317.60	317.20	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.87	0.70	-5.53	3	49	2011-06-01 16:08:56	2011-06-01 17:08:56	1	3	3	0	0	53	0	296.20	78	57.10	CHANGED	ERRNLEDLSSTSPTDGTIGKRVSNTRDWAEGSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDHoSGANNGNVCLVSDAKVLSYAPEIAVSKEDRETDLVHLEDKLSoTGLNPTAVPFTPKNLSsPAKDSPVIAEHYYGLGVREQNVcPQTsRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSsGpKP.ESVG+sIEGQSlRDsLQl.KsNKssDsPGAGPKDSAVKEcs....PQKRLPMLAEEFECSGSEDPIIQELLKENSaINuQQGKDAQPPYapGIEuSpSPDKTEITuDA	EGRNVEDLSSVTSSDGTIGQRVSNTRAWAEDPDDIQLDPMVTDVVYHDHGGECTGHGPSSSPERGWSYHMSGTHDGNVRAVPDTKVLPNAPKTTVPEEVGEIDLIGLEDKFASAGLNPAAVPFVPKNQSTPTEEPPVIPEYYYGSGRRtDLSKSPPRGNVNLDSIKIYTSDDEDENQLEYEDEFAKSSSEVVIDTTPEDNDSI..NQE..EsVGDPSD.QGLEHPFPLGKFPEKEETPsVRRKDSLMQDSCcRtGVPKRLPMLSEEFECSGS-DPIIQELEREGSHPsGSL.+LREPPQpSGN.SRNQPDRQLKTGDA..	0	0	0	0
+14163	PF14321	DUF4382		Domain of unknown function (DUF4382)	Eberhardt R	re3	Jackhmmer:D2PI33	Family	This family is found in bacteria and archaea, and is typically between 142 and 161 amino acids in length.	25.00	25.00	25.20	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.90	0.71	-4.10	62	266	2011-06-02 07:47:30	2011-06-02 08:47:30	1	4	221	0	121	260	33	151.60	24	46.45	CHANGED	ssGs....lslslTDA...P..ss..sh.....ppVhlslsplplp...t....sss................sps.......shh...shs.......spp...lsl...........................thhsus.tp.....Ls.........ptslP.uG.p.YsplRLhl.s................s.........ss.......................ls.h...s...G....sphs.LpsPSut...ps.sl.Kl....s......s..hslp..uss.sshslDFDsppSl.......s.tG.ss..pYhLKP	.......................suslsltloDA...P..ss..sh..............spVhlslsplplps....sss......................................................sss........shh..sls............spp...lDLh..........................thtsus.tph.....lu....ptslP.sG.p.YpplcLhls................s..sp..............................lsh..s..G.....sphsLpsPSst.................ps..tl.cl.....p................shslp.sss.sshllDF-hp+ul.......s.pG..ss....pahL+P...........................	0	39	73	106
+14164	PF14322	SusD-like_3		Starch-binding associating with outer membrane	Coggill P	pcc	JCSG:Target390309 Jackhmmer:Q8A1B4	Family	SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.65	0.71	-4.24	44	6539	2012-10-11 20:01:04	2011-06-02 11:11:39	1	8	205	26	1561	6470	663	202.60	17	36.62	CHANGED	caLDhp.Ppup....h..sps......h.chps.....hls.....sh.h...ssh.s......hht...thh....thsp.hh..ss...hsss.h...s.t...tsh...h.t......ht..h.........pphsh....s.....s......sss..s......shWsshYp.sI...hssNhlLcp.........s...pp........p.hs....t.....lh.GEAhhhRAataahLssha.............u............t..l..Ph.s............p....sss...........s.............p...............t..s....h........s..Rs..Tlp-lYppIhsDLppAhsl.Lspst...............ph..+hsh..puA.hAhhARhYL	......................................................................................................................................tt.................phpt........hht...............sh.h........tth...t...........................t....h..................t.......hh..........sp.............hhs.s............t.....t.......t.s.h..t.t................h.......................tp..h..ss.......s.........s.............sth....p...........................sh..W......p......t.......h...Y......p......s.......I..........ppsNh...h...lppls.........tth.s...pp..........................p.tp...p........hh..uEAh.......hlRAahY.a.pLlpha.........................G...............s...l..P.l..h...................s......psp....................s...................s....................h....p......h..........s.....R.s....o..h.p.-....l..h...s.h....I...h.p...D.L...p.....p.......A..h......s......h......L..s..tptst.................................hs...R...hsp...suA.hulhu+hhL................................................................	0	739	1439	1561
+14165	PF14323	GxGYxYP		GxGYxY sequence motif in domain of unknown function	Coggill P	pcc	JCSG:Target393069	Family	This family carries a characteristic sequence motif, GxGYxYP, but is of unknown function. Associated families are sugar-processing domains.	27.00	27.00	64.20	29.60	23.30	22.90	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.69	0.70	-5.78	18	103	2011-06-02 10:20:36	2011-06-02 11:20:36	1	8	61	1	42	97	11	377.40	22	66.51	CHANGED	hlsoLQGlVNp.opspIY.l..psp.s.....s.pphhcphppp..hG.lsasc..lss..sasLLs+a+p..tlcGhVlYDsp...pssSlNlAsolAGlcsulslspsLhsplpstGlpt..l.t.DlRs..hs.......tp.......ahYsp.YhsphsHphlltLs..Pc...ph.stLRDYAl...h....op.uhlFhDssss...-..........psLhcphhusMss.u.uhshGWa......s.D.Et.sVphuSpaGluhluuDashNLoVhSuhsp.osshp....ptsshst.....hpNKhYVoFlhSDGDNlQas....ashpphassPs..RGplPlGWolSPuhh-luPslLsaYYcoA...osN..DsFIuGPSGsGY..hYPsph.............sp.s.p.LssahphspsYMp+ssh+llsIhD....ssshs.stsl.hsp.........astp.ssl.ulah.sasppss.......Gplhh..NstPslupcshhh.tlps..ph....pslpspIspuhsshss.sPtFhhl.lcsWsp.sh.sslpslhspLs....pN....lcVVsPDpFhpLh+c	......................................................................................................................................................hsolpGllsp..pp........pla.h....t............p.t.hhtth.pp.....ht.lt.hp....hps....tllphapp....hpGhllasst......ohs.Asol.Aulpsulsh...s.t..h.th.lp.thsh.....h...Dh+s..hs...................ht.......ahhpp.h.sthspphl.h.hs..sp......h..h.lp-ash....hsp..hh.a.h.pss.......p...........hslhpplh..st..h....t....s..u....hhGW.............s.c....Eh..lphsSp.h.G..h.h.lsuDa....Nhohhosh.....p...h................p..t..........pshhYlsahhSDGDNhQa.......ht..p..hasss...RGph......shsW.olu.P.slh..hsPslhphahpsu........s.N...D.hlsusSGsGY..hYPsth.............sp.s.t.httahphhppahpphs.phh..lh.s.......t.t.......t.th....hpt...hh....th.uhhh.tht...........h.h.h......sth....sh.t.p................................tth.t.ltth.t..tt....a..l.h.sWt.......pth..hht.ht..........h..h....h.............................................................................................................................	0	34	40	41
+14166	PF14324	PINIT		PINIT domain	Bateman A	agb	Jackhmmer:	Domain	The PINIT domain is a protein domain that is found in PIAS proteins [2]. The PINIT domain is about 180 amino acids in length.	27.00	27.00	28.00	30.60	24.60	26.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.77	0.71	-4.11	38	474	2011-06-02 13:21:12	2011-06-02 14:21:12	1	9	214	1	256	469	0	149.60	39	24.75	CHANGED	shtsslpFKcsPFYclh.chlpsos.h.ts.....................sp..p+ppsp..hpFpLsspphpplpst..........p...shplhLhst...........sh........hssss.spphpFP..slpl+lNsp.lphshpu.psKsGs.....sRPsslTs..al+hs...sh.Nplplsass.....ssc.............pYhlhlhLVc	..................................+P-lphppLPFYcllspLl.+P....osLssss............................................sp...+h.p-sp..hhFsLTP.p.Q.lppIpssh-.........t.h-hslQV.LR............................hCh........s-TSs.sQEDpFP..sslplKVNsc.ss.lP........sh.hPssKsGsE................KRPsRPlNITs.........hl+LS..ssssN..pIsloWus.....hs+...............sYshulYLV+.............	0	53	96	175
+14167	PF14325	DUF4383		Domain of unknown function (DUF4383)	Eberhardt R	re3	Jackhmmer:C1CUZ6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	27.00	27.00	27.10	27.20	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.72	0.71	-4.11	66	192	2011-06-02 14:11:15	2011-06-02 15:11:15	1	1	132	0	100	202	10	124.70	29	79.76	CHANGED	sphsAhshGslalllGllGFl..PGlss..st......................hsstputuhLhGlFtlshLHNllHLlhGlsGLh..hups.ssuARhahhshGhlYhsLhlhGlhhs.......tp.oh..........sshlPl...............NsADsWLHlslulshlslGhhh	...............................phsAhllGslaLllGllGFl...Puhss...........................hsttstuhLhGlFs..lshLHNllHLlhGlsGls..huts..tssARsahhssGslYhllhlaGlhss.......ts..sh................sshlsl.................NsADsaLHlshulshlslGhh.h.......	0	32	69	93
+14168	PF14326	DUF4384		Domain of unknown function (DUF4384)	Eberhardt R	re3	Jackhmmer:C1CXC5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	27.00	27.00	27.00	27.00	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.51	0.72	-4.15	69	228	2011-06-02 15:09:03	2011-06-02 16:09:03	1	22	137	0	127	233	36	83.10	23	20.24	CHANGED	ssYphG.-plphtlps.....scsuYlhlhsl..sssG.plshlhPNthpts.........NhlpuupshshP........sstas.....hplssPhGp...pplhslsoppsl	.............................aphG.-plpltlps.......spsu.Y.lhlhsl....ss.sG..pl.shlhPNthpts.........shlpuspsh.plP..........sstap........hpls.sPh..Gp....-plhslsopp......................	0	39	84	118
+14169	PF14327	CSTF2_hinge		Hinge domain of cleavage stimulation factor subunit 2	Coggill P	pcc	Jackhmmer:Q8VYM7	Family	The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localisation. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex.	27.00	27.00	27.40	27.20	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.37	0.72	-3.90	52	428	2011-06-02 16:18:23	2011-06-02 17:18:23	1	16	266	3	292	397	2	82.30	36	19.13	CHANGED	..lPsshs...sshpss-sIopsLuslsPsQLh-llsphKp.LsppsP...spAcplLtpsPQLuh.AlhQAhllMshl-spllppslpp	..............................................h.sshs.s..ss.sus-.sIopsluoLPP.pQhh-lhpQMKh...hspssP....pcA+phLhpNPQLAY.ALhQA.llMplVD.sphhhphlp.t...........	0	85	153	229
+14170	PF14328	DUF4385		Domain of unknown function (DUF4385)	Eberhardt R	re3	Jackhmmer:C1CYW3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 149 and 163 amino acids in length.	27.00	27.00	32.30	32.20	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.87	0.71	-4.27	28	238	2011-06-03 07:02:05	2011-06-03 08:02:05	1	1	235	0	57	138	307	138.60	63	93.28	CHANGED	FDYshDatpIDa..RppPEhYRVGRGEQGVLLVEPYKSEILPaWRFKTP-lAcpSS-KIYphFhsYhcpsDFlGMDMARKFLQMGaTRARRY.ANaKGG+KY..p..............sptcl.cpptD...scKAcuApIF+ppWcps+scppYhchKccapc...cY	.............FsYp.DFssIDF..RppPELYpVGRGEQGVLLVEPYKSEILPaWRaKstssAhcSAEpIYQLFEsYRpQDDFVGMDMARKFIQMGYTRARRY.AN...YKGGKKY.s...........................--GpLsscssD.......PlKAAAAslFKuhWD.+lRpDEDYL++K+pHQt+a.............	0	18	30	46
+14171	PF14329	DUF4386		Domain of unknown function (DUF4386)	Eberhardt R	re3	Jackhmmer:C1D3W7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.	24.80	24.80	24.80	24.90	24.50	24.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.58	0.70	-4.86	69	193	2011-06-03 07:11:31	2011-06-03 08:11:31	1	2	136	0	112	204	60	194.10	19	88.70	CHANGED	+huGhlaLlhhlh.....ulh.uhhhhtshl.........sssshssltsptshhphuhhhthlhslhslslAlhLahll.+..thspslAhsssshRll.tsslhslullshhsslhlh.ssssh..s.t.............th.shshhhhshashs..a.luh.lhh.....GlphllluhLhhRSthlP+hluhhhlluuhhhlhsshhphhhss.....thhshhhhlshhlsEluhslWLll+Gh	..................................................hsGhhhlhhhlh......uhh.u.h.hh.shl.........ssthht.thhspt..s.hh.hhuh.h.h..hlhslh.lshulhLa.ll.+...ths.......shuhhhs.hhtll.tus.lhshul.lthhshh.lh.pt.....................th.thshh.hht.htshs......hhlu....lhh.....Glthllluhlhh+ot....hl.........P+hluhlshluuhhhlhss..hhthhhst..........ht..hhhlshhlhElshslWLlhhG...........................	0	62	87	107
+14172	PF14330	DUF4387		Domain of unknown function (DUF4387)	Eberhardt R	re3	Jackhmmer:B5YEU8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are approximately 110 amino acids in length. There is a conserved RSKN sequence motif.	27.00	27.00	37.00	36.90	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.03	0.72	-3.67	38	189	2011-06-03 08:26:29	2011-06-03 09:26:29	1	5	181	0	59	130	55	98.20	54	62.14	CHANGED	Lt-lAcsIRSKNAGPa.lThDIhFcspcsY-plKposslspchlucLYtlss-cl.phh.a-sApAlKholsR.....shs.uGuhG-pDlaGuQQauPLLslpl	....ssLApVIRSKNAGPYELslDIlFKo+EsY-RVKsSutLTsElIAcLYclcP-hIhcIVaFDPusAlKIshPR.....slh.SGslGDsDVYGAQQHAPLLshp.h.....	0	19	37	50
+14173	PF14331	ImcF-related_N		ImcF-related N-terminal domain	Eberhardt R	re3	Jackhmmer:Q7UL74	Family	This domain is found in bacterial ImcF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the ImcF-related domain, Pfam:PF06761.	25.00	25.00	26.10	25.20	23.90	24.60	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.54	0.70	-5.49	110	1314	2011-06-03 08:45:58	2011-06-03 09:45:58	1	12	877	0	250	1135	43	257.20	27	22.64	CHANGED	sssptDpstWpuFLsLL++pR.sRpPlNGlllslu.lscLlsss.stp...ptpApslRtRLpELpppLuhchPVYlllTKsDLlsGFs-aFssLspp.pRp.QlWGhT.h....shs...p..sss..sst..........hpp-astL.hpRLsspl.s+LppE..p...Dhp....cRstlasFPpQhuuLpshLtpalpplFtsspapps....shLRGlYFTSusQpG..s..s.h..s..p..ht..sh........s.p.......ph.......s....hs....ts.......s..s...s......s.....t...t............ss...s+.oaFlccLhpcVlFsEusLsu.ssh+hpt.....t.R...hh.t.ht.st.h...ssh.ss	........................t...t.ptt.WtthLshL++pR....s+pP.l.NGlllslsls-L.lssstpt..t...pphupsLRpRLpElpppLthphPVYlllTKhDLLsGFspaFpsLs..pp.pRs...plhGhT.hshp..t..ppsssh..................tthspp..ap.pL.hp+lsttlss.thttp..h....ssp.......pRstlasFPppht.u.LppsLtphlptlht.sst...apts....shLRGlYFT.........SuhQpG....ts.....s...h..sp...sh...............sp.......pa.............ths..tt..............s.....t....t.................................ss..sps..aFh+pLhspllhsEs.s...Lss..sh.p.hth....pt.R.hh.h.hh.hhh.....hh..................................................................................................	0	47	109	179
+14174	PF14332	DUF4388		Domain of unknown function (DUF4388)	Eberhardt R	re3	Jackhmmer:B5YCM3	Family	This domain family is found in bacteria, and is typically between 102 and 135 amino acids in length.	25.00	25.00	25.10	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.31	0.72	-4.18	165	493	2011-06-03 11:45:10	2011-06-03 12:45:10	1	42	129	0	296	484	46	131.50	20	34.04	CHANGED	pG.sLp...sh.sLs-llQhlptsp+oGsLpl.....pt.st............................lah..ccGpllp..Apt.s.............................................................thpupcAlhpl.l....thpp....GpFp.................ht.tthstttslph.sh..ppllh-uh+ph...DEhpth	....................tG.sLpph.sls-llphlptsp+oGh.Lpl..pttstp..up...............................lahppG..pl..ltApts............................................................................phps.pcslhpl..h.......shpp..Gp.Fp.............ht.ss.ttttplph...sh....ptllh-uh+hh..-ch..h...................................................................................	0	125	211	281
+14175	PF14333	DUF4389		Domain of unknown function (DUF4389)	Eberhardt R	re3	Jackhmmer:Q0EYR1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 104 and 223 amino acids in length. There is a single completely conserved residue R that may be functionally important.	25.00	25.00	25.20	25.10	24.00	24.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.65	0.72	-4.27	51	266	2011-06-06 07:50:20	2011-06-06 08:50:20	1	2	225	0	91	250	268	80.10	31	48.89	CHANGED	hpppshahRllaMllhslhhpluphllhllsllQalhhLls.GpsNppLtsFussLupahhchhpahoaso-c+PaPF.....scaP	.................h.....hh+hlhhl.a.....hlVhhhhphshsslsllthhhhLho.GchspsLhsFssul.pahh+l..u..tYs..s..h..t..oDchP.PFs.............	0	38	59	83
+14176	PF14334	DUF4390		Domain of unknown function (DUF4390)	Eberhardt R	re3	Jackhmmer:Q0F0K5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 192 and 203 amino acids in length.	27.00	27.00	29.00	28.30	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.70	0.71	-5.06	70	309	2011-06-06 07:59:00	2011-06-06 08:59:00	1	1	306	0	114	259	83	164.20	31	82.02	CHANGED	utAsshplpp.hplp.tsc....sslh.LsuslphpLsttlc-ALpcGlsLhFsh-hpltRsRhaWh...Dcplsp.....tshph+LuYpsLT+paclstss............hspsasoLs-ALpslt.clpshtlhstu.........plpssp.sYplplRhcLDhspLP+PhQlssh.spssWslsos.hhp..aph	..........................tApslplpcsphp..sss....ushp..lsuc..hch-Ls..spLc-Alp+GlPLhFshchpLs+sRh.....aaa...-cplsp.....sshsh+LSapPLT.ccYRVosuu............hphsasoLcsALpslt.cls..sW+V.hsps.........plpsup..s.apuplRhpLDsupLP+.PFQlsAl.sspsWpLsSs.Wpph....h...................	0	35	76	95
+14177	PF14335	DUF4391		Domain of unknown function (DUF4391)	Eberhardt R	re3	Jackhmmer:Q0F339	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 220 and 257 amino acids in length.	29.90	29.90	30.10	30.20	28.70	29.80	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.06	0.70	-4.95	57	203	2011-06-06 08:05:32	2011-06-06 09:05:32	1	2	194	0	61	189	15	216.40	22	92.12	CHANGED	lslPpsst....ls+p........lPKpthh..cpsshssppKchhs-sl..-pIhahhplsspoh.sls....sspphpEItlhplpL+s..t....phspclh...cllp+tlPh.llh.lhp.....h.sschthshsaK...Rhsps-tschsl.pphhtosW............thhpslshs.h..thshtslYpshlpplhthps..............t.ht...........shtpphpthcphpclpcclspLcschp+E+Qhs++s-lNtcl+clcpcl	...............hslPpsst....ls+p........lPKphhh.....pps..shosp.Kphhhppl..-pIphhhtLpsssh.sls....sspph.El.llplpLps....p...............phs.pclh...clIppt...l...hsllh.hlp.......................h.ssphphshuh+...Rhttscts+hsl.tphatosW........................................................th.sp..lphp.h..sh......sltslYpslhpplhhhssph...................t.....................slstphtphpplppLppclscLcpchp.+-+phs++sElptcl+chcppl............................	0	25	44	55
+14178	PF14336	DUF4392		Domain of unknown function (DUF4392)	Eberhardt R	re3	Jackhmmer:Q0EY62	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.	27.00	27.00	27.80	37.10	25.30	24.90	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.69	0.70	-5.61	49	194	2011-06-06 08:24:43	2011-06-06 09:24:43	1	6	147	0	85	191	48	279.00	31	62.43	CHANGED	pl-pll..ssDhstcG...ltthh......ssu.hhpAup.......hL..................ppsppllIsTGFsl.....ssssETDGPsGAhsLupALpt.lGtcshlls-p.stpslpshhpshsh..ps..h...............................................tt.hpphp.shlluIERPGpusDG.pYasM+Ghslsth..ssshD....tlhhpupp...slsoluIGDGG.NElGMGsl.pptl.phlshusp..........hhusspsDpLllAsVSNWGuauLsAtLshhts.................................hl.shcpctp..hLctllptG.ulDGlotps.sho..VDGlsh.phptpllctLpph	............................................lpphh..shD.Gt.+G...ltplh..........t.st...lh.c.AuhtL.........................spsppVlls....TGFPs...........ttsstETDGPsGAlu......luthLpt.lGtcsslls......Dpp..shshhpthhpsts...psh.th.hs...........................................ttps..pp..p.hctlluIERsGpAsDG.pYaNhRuhsI.pph..ssslDpLFhtApp.......GlsohGlGDGG.NElGMGpl..cptlpphl.pGs...............IAsslpuDhhllAu..............VSNWGuYALsssLhhLts................................phl.s.hppc.ct..hLphllptG.shsGhott..shp..VDGlsh.phatphlptLh..h............................	0	28	37	58
+14179	PF14337	DUF4393		Domain of unknown function (DUF4393)	Eberhardt R	re3	Jackhmmer:Q0F0Z8	Family	This family of proteins is found in bacteria, archaea and viruses.  Proteins in this family are typically between 254 and 285 amino acids in length.	25.00	25.00	25.20	25.80	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.25	0.71	-4.85	48	194	2011-06-06 08:50:57	2011-06-06 09:50:57	1	3	178	0	46	155	1	182.20	21	69.96	CHANGED	c+lpplsp...cs..ltpss..splssssl-supat.ss-pLpchaupLlAsuhspspsppsHPuFscIlcpLossEAplLphlt................tsthshhshthhh..............pstshphhhsshhhhspp............s.pphss.lsNLpRLGLlphs...........h.h.ppthhpthcstphhpphttpht................................................thlplTshGppFhpssh	............................th......pt....h.ps....plhhssl-sspa....hspcpLpphaApLl.usuh-pp.pss.sH.uFlcIlcpLoss-AplLphlt.............................................ppp.hPhsphthhh................pststth.hhpsh.hhspt...................pphsh.lsNLhRLGLlphs.............hspps.hphh.t.s..thhpph.pth......................................................t.lploshGptFhpsC......................................................................................	0	11	32	40
+14180	PF14338	Mrr_N		Mrr N-terminal domain	Eberhardt R	re3	Jackhmmer:B5YBC5	Family	This domain is found at the N-terminus of the Mrr restriction endonuclease catalytic domain, Pfam:PF04471 [1,2]. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition [2].	24.00	24.00	24.20	24.20	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.91	0.72	-3.90	132	557	2011-06-07 07:50:11	2011-06-07 08:50:11	1	9	518	0	145	476	56	89.00	25	28.56	CHANGED	sapp............hh....hPlLchl..p-.Gt...ptphp-lhctlscphpLo-c...ctpphhs...oupph.hapsRluWApoaL.......p+AGLl.cs...sp.RG..haplTcp.......GpplLtpss	..................hpphhhPlLchL...ts.sp...ststc-lhc.tl.sct..h..s..ls-c.....pts.ph.hs....SGpp..hhpsRlsWApshL.......ppAGll..pp...sp...RG..haplTpt.......Gpphltt..........................	0	60	101	124
+14181	PF14339	DUF4394		Domain of unknown function (DUF4394)	Eberhardt R	re3	Jackhmmer:C1D3Q3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 262 and 476 amino acids in length.	22.50	22.50	22.70	22.80	22.40	22.20	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.58	0.70	-5.08	47	116	2011-06-07 10:49:46	2011-06-07 11:49:46	1	11	90	0	47	134	22	221.50	32	63.35	CHANGED	sphLh.hsssssspstpshploG.h.ssppLlGIDaR.........PssGpLYul....usp.upl..YoIsssoGt....uohl..........uthssslsus...shulDFNPsADRLRllos...sGpNLRlssD.......sGs......hshsD.........ssLshsssshp.u..............ssslsAuAYTNshsssp.s......TsLasIDsstst..LlhQs.........sPNsGsLsslGsL...Gl..ch.ssssGFDIs....sstt......ssssuassh....u..t.s..pLYpl-.........LtTGpuo.......thus..........lss..t...ltslAl	..................s..hl..h.sspssthhpshtloG.h.s.sppllGIDaR.........PssGpLYul.......sss...uplYolsssoGs.........AThl..............uthssslsus...shulDFNPss...D.....RlRllus...sGpNLRlss-.........sGs.........hs.sD...........GsLshs.ss.t.u.............t..ssslsAuAYTNshsssp.s.......TsLasIDsshs..tLhhQs.........sPNsGsLsslGsL.....Gl.....sh...ssssGFDIt..........s.ts..s.sttAatsh....s..s..s..pLYpls.........L..t.....T.GtAo.....thup.................lss.......ltslAl.................................	0	22	37	43
+14182	PF14340	DUF4395		Domain of unknown function (DUF4395)	Eberhardt R	re3	Jackhmmer:C1CVW5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	24.00	24.00	24.50	24.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.66	0.71	-4.08	65	233	2011-06-07 11:45:19	2011-06-07 12:45:19	1	8	221	0	115	246	199	131.10	30	78.15	CHANGED	lD.pusRhsAslsslllllsLlsu........shh........lLsl.slsFslsshhGs+huPau....hlh..tplltPpL...ssschEsssPhRFAQhlGhlFussu.hlu.ahh.....GhssluhlssuhslsAAhLsAuhGhCLGC.lYhhlp+h	....................................................................ls.pusRhsAhlsslllhlsllss...................thh........llsh.slsFsls.shhG.s+hsPau.....hlh..t...plltsclt..sssc..h..EsssPhRFAQhlGhlFsssuhlu..ahh......................Gh.shl..uhlssuhslsAAhLsushGaCLGC.lYhhlt+.h........	0	40	87	105
+14183	PF14341	PilX_N		PilX N-terminal	Eberhardt R	re3	Jackhmmer:C1CZZ9	Family	This domain is found at the N-terminus of the PilX prepilin-like proteins which are involved in type 4 fimbrial biogenesis [1].	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.35	0.72	-4.30	69	454	2011-06-07 12:24:02	2011-06-07 13:24:02	1	4	373	0	154	436	62	50.80	32	22.54	CHANGED	pGhu.Lll...uL......llLll.lollulushps...shhpp+huuNppppppA....a.uAEuulp	.....pGhs.Lll...sL......llLll.lolluluuhps...sshpp+huuN.pcpphA.....hpsAEuuLp..............	0	45	102	134
+14184	PF14342	DUF4396		Domain of unknown function (DUF4396)	Eberhardt R	re3	Jackhmmer:C1D417	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 167 and 310 amino acids in length.	27.00	27.00	32.00	31.90	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.77	0.71	-4.07	54	240	2011-06-07 12:30:05	2011-06-07 13:30:05	1	4	225	0	106	237	1104	138.70	29	53.90	CHANGED	shWppustuTlHCLsGCulG-lhuhhlsps................huhshhsth.sluhshuhhhGhhlphhslh..hpshshtpAl+tAlts-hlSlsshElu.ssshhhl...............uhshshssshFWhs.htluhhsGFlsshPhNhWhlp+GtKc	.............................WppsshuTlHClsGCslG-lhuhhhhph................huhshhsph.slshshAhhhGhhlphhslh..hpsluhtpAl+pAhts-hlSlsshplu..sshhhl...............uhshshssshFWhs.htluhhsGFlsshPhNhahlc+GhKc............	0	27	58	87
+14185	PF14343	PrcB_C		PrcB C-terminal	Eberhardt R	re3	Jackhmmer:C1CVC9	Family	This domain is found at the C-terminus of Treponema denticola PrcB, Swiss:B8YNY4. PrcB interacts with the PrtP protease (dentilisin) and is required for the stability of the protease complex [1].	24.00	24.00	24.30	24.00	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.72	0.72	-4.26	96	234	2011-06-07 13:08:52	2011-06-07 14:08:52	1	11	210	0	92	220	20	60.10	26	27.35	CHANGED	phall.lshGp+sTuGYulpl..pph.t.s...pssl...hlpsplhsPstsphssps.....h........TaPa...hllclpt	...................hlh.hshGppsTuGYulpl....ppl...ths......pssl.hlp...schhsPp..ssphssps.....l........TaPahllph..t...........	0	50	74	87
+14186	PF14344	DUF4397		Domain of unknown function (DUF4397)	Eberhardt R	re3	Jackhmmer:C1D258	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.	26.00	26.00	26.30	26.00	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.58	0.71	-3.79	91	801	2011-06-07 13:44:06	2011-06-07 14:44:06	1	13	358	0	263	753	167	108.00	22	64.45	CHANGED	sutlRVhH.....uuPs.......uPsVDVal..ssph.........hlsslsapshos.YlslssGs.aplpl..hssGss.s.sss.lhsssl.sltssppYTlsAssshs.....s..hph........hshsDsh...p....t.hssspu.plplhHsuPs..A.PsVDlhl	............................................s.lRhhH.....hsss.......sPsVDl.h.l...sGpt............lhpsls.ap....p....h....o......s..Ylsls.sGs.aslpl....sss..uss.............s..l..h......s.ssl.sltssptYTlhAl.spss...........s....hph...........................hhh.c.....................................................................................................	0	85	185	241
+14187	PF14345	GDYXXLXY		GDYXXLXY protein	Eberhardt R	re3	Jackhmmer:C1CYU2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 171 and 199 amino acids in length.  It contains a conserved GDYXXLXY motif.	27.00	27.00	28.70	30.30	25.70	18.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.91	0.71	-4.34	106	394	2011-06-07 14:04:33	2011-06-07 15:04:33	1	4	391	0	107	331	16	153.40	27	55.03	CHANGED	lplshlshhlhpppthltpGcslhLclsPVDPRsLhpGDYhsLsY..slup.....................................tthtps...spsalhL..p..-spul...........sphhphpps...........s.tssplhlps.php...................................t.pl.....phu..h.-saahsEGpupphcp.sph.................uph+Vssp.GpulLhsLh	..............tlshlshtlhpppthLppGpslhLpltPVDPRsLhpGDYhsLsY..slss.s......................................t.p.tts........ppsalhlc...Dspsl...................................sshsphspst..........shsssphhlps.cht............................shpl..phu........h-pYahsEGpucphpp.u+h.................................................uth+Vssp.GpslLhsLh...............................	0	30	60	86
+14188	PF14346	DUF4398		Domain of unknown function (DUF4398)	Eberhardt R	re3	Jackhmmer:Q0F2G1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 127 and 269 amino acids in length.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.85	0.72	-3.97	51	449	2011-06-09 10:03:32	2011-06-09 11:03:32	1	13	287	0	153	393	38	104.80	24	52.41	CHANGED	hsshhluG..C...Au........sshs.spphptucpAlppApss..sAsp..hs.s......cLptAppcLtpA.ctshsppchp........pAcphAppApsc...AclApspupstpsppthpchpps..lppLcp	..................................................hhhhuG.C..us.............tshs.spphstAppulppAcps...susp.....A.sh........phcpAp-pLspA...ctu....h.p.c...t.pYp........cA.+plAppAptc...AclApp+u.sspspptlpphppt..hppl................................	0	42	68	114
+14189	PF14347	DUF4399		Domain of unknown function (DUF4399)	Eberhardt R	re3	Jackhmmer:Q0EYV0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 135 and 1079 amino acids in length.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.07	0.72	-3.96	72	404	2011-06-09 12:43:37	2011-06-09 13:43:37	1	27	222	0	152	401	417	86.80	32	24.73	CHANGED	VpFGLcG.hslsPAGp.tpss.....TGHHHLLlDsst.........shspslPts............tptlHF.....GsG...QTEs...slp.LsPGcHTLpL.hGDttHhsa........ssslhScpI	.........................................hGlps.hslsssup..hpss.....TGHHHLLlDsps.........sh.spslshs.............stlHa.....GpGpT-splp.L........sPGcHTLpL.h.uDt.Hhsh........t....o........................	0	22	100	127
+14190	PF14348	DUF4400		Domain of unknown function (DUF4400)	Eberhardt R	re3	Jackhmmer:Q0F326	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 209 and 249 amino acids in length. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	30.40	29.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.20	0.71	-4.93	58	389	2011-06-09 13:00:12	2011-06-09 14:00:12	1	2	295	0	93	325	19	189.70	27	84.40	CHANGED	huhhahhs-puhp+upphhppphshLusphs.cullhp..........psu..h......hh.......haphhFVc.oGhhshhpp...................s.tt.ttshphhsshhhphhpsalhushhsshhhhlRLs.lLhhslPlFlhsslsullDGLspR-lR+auuGhESualYH+A++hlh.shshs.hhlYLuhPh.ul.Phllhl...PsAlllGlslslssusFK	.................................................................................hhh.s-ts...hpp.pt.hphphshLusp.hspslhhp...................pss.....................haphhhVc...oGhhphhpp..........................ttttp.t.s.pshp..h.sshhhshhpsal.AhhhshhhhhlRls.lLhhhlPlhlhhhhsulhDGLspRclR+auuGhESualYHpApthlh.shhhls.hhlYLshPh..ul.Phllhl.....PsAhLlGlulshssusFK........	0	13	43	74
+14191	PF14349	SprA_N		Motility related/secretion protein	Eberhardt R	re3	Jackhmmer:B2KAY0	Family	This domain is found repeated three times in the N-terminal half of the gliding motility-related SprA proteins. The role of this domain in motility is uncertain [1]. It is also found in proteins required for secretion [2].	27.00	27.00	54.90	27.30	22.80	24.20	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.77	0.70	-5.23	88	445	2011-06-09 13:24:56	2011-06-09 14:24:56	1	3	146	0	160	475	719	425.90	19	52.43	CHANGED	tahshts.hh.h.tt..............hhs-P.............Yph.ahtp.......pl......................hp+Yh..................h...p.ttpshsssEc....pcsshsphpp..ah...pa+lsh...pssp......hhhG.ps..........hhlc.ps.splshss.......pahphc.P.........................olphhphahosFshshhlphushshVtuchp...sYsp...sh.s.s..sp.h..pht..............................pph-lusVslppNssh.........l..h..ssh.ptps.ss....sstlphscpsLohhlsp...........psucu+sV.....hpsps..lshcpYcchchF..............................tlGpsapsNY.p.pls.......s.....tpshshst...plW..hsNp...........s...t..sshc..h...................................ttphslhu.sslG..csh..tlpN.s..........................hsthsp.....sssslssshu-hsssshsuph...thhs.ppssp..ctppshpphsh......sth...s.phshphshh.utpp.........p..s.pasPhhsslpLpstLs	..........................................................................................hs....hhhh.tthst...........hhhss-s.............att.ahtp...................pl.........................hp+Yh.....................................ht.p..tp..shssscp.....psphschth.hspachsh....s.tp............h.hGst..........hpl.s.pGssplshGs..........ph...c.P...................................slp.tpcahssa......shsphlp..hs..uhlsuphphphsYps...sssa.shpsp..hhhshp...........................................................p.phspphplGslshp.spph............h....h..ssh.ttpstsolaGhssphpts.cptLohhlsp...........tsspspsl..phshpsp.h.lpstpYcp.pha................................hhupsah-sapp...sh...............t.....posl.slsp...plW..lsNp........s........ss.hp................................................tppRslluh.slu.....psh......h.t............................h...........ss....ssl.ssshu.shts.hp.hstph...thhs..p.p...tsp..ptppshpshsh...................t.phshh.st+t...t..papassths.h.Lp.......................................................................................................	0	73	145	160
+14192	PF14350	Beta_protein		Beta protein	Eberhardt R	re3	Jackhmmer:B2KEQ4	Family	This family includes the beta protein from Bacteriophage T4, Swiss:P13057. Beta protein prevents the gop protein, Swiss:P13058, from killing the bacterial host cell [1].	27.00	27.00	27.30	27.20	25.70	21.10	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.24	0.70	-5.26	43	134	2011-06-09 13:40:16	2011-06-09 14:40:16	1	1	129	0	34	119	2	313.80	20	94.46	CHANGED	YhPlL..+h+puEhpALpp.L..ssps+sp.lhPllplsthststpp.................pptspcltpshspt..shhsssp.......................pphhpsssthhs..hhhphhpptstp............llPVlshspss.....ph.psltpth......ttttlslRlptsphts.....phtptlspllstls.htss.phtlllDhtshp.sts.sthtthhsth......lpplsph..tapslslsuoSaPps.......hsshst.....ppstl.RtEhplapplts.......sttshaGDYusspspht......sstsspsss+lcY....ot.csp.ahlhR.stthpt.tht.......phh.sluppll...spst..a...ussaSWG.DphIpps.Aps..........ss.......GssopWhplssspHlshhlcp.l	......................YhPhL..+h+.puEhpALp.....pL...s.phtst.hhPlhpl....hs.p.................................pphhppltp.hstt...hh..sh........................tthhpsspt.ht......hhp.hpthsh.................llPVlthspss.....phhptltphh........tttlslRlp.t.th.s..........t...lspllsphs..h..s..ph.lllDhtslp.stst...th.tphhtth......lsplsp....hpplh.lsusuaPss.......hsshst.....t.tpl.RhEhplapplhp........hpshauDYushpsph.......s.thhp..ssplcY.....oh.csp.ahhhR..tthpptsht............phh.phsppll...sssp..ap..s.sp...asWG.DphItps.ups.........tss..............GssspWhplshspHlshhlcp................................	0	7	23	31
+14193	PF14351	DUF4401		Domain of unknown function (DUF4401)	Eberhardt R	re3	Jackhmmer:B2KEA1	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with Pfam:PF09925.  There is a single completely conserved residue K that may be functionally important.	25.00	25.00	25.20	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.54	0.70	-5.44	44	202	2011-06-09 14:25:50	2011-06-09 15:25:50	1	7	199	0	48	196	9	311.50	20	56.27	CHANGED	sWalplh................huhuuWlAulh..hLsFlhhshhhh.c......hshllhGllhhuhAhhlh....+tp.............thFhcQhulAhsluGphhlsaGlhphh.......thhshhlhhhhlhslhhhlh.s...hlhphL.shhhshshhhhhtthhh..........h.lshhhlshhhshl......hhth.........ttstththhpslshuhhlshlshhhhhsht.hhhh.................................th..hhhhhhhhlshshshhhlhhphph.l..ssshthslhhslslluhh.h..hsulshulllllluhhtspphlhululhsllhhluhYYYsLploLLtKShhLhusGllLLshthllh+hh	..................................................hhlphh................huhuualAulh..hLhahhhhh.hh.p......sshlllullhlshAhhlh................+t..............shhhpphulshhluGp..lhhhaslhp.h...................hhhhlh....hhhlhslhhhlh.s.....hhhphL.shhhshshh.hhhshhhh.................h.lh.hhhhshhshl.......hh.hh............tthhtttlp.sltauhhlshlshhhhthh.hhhhh..............................hh....th.thhhhhhhhhshhhhhhhhhhh...h.h.hh....ptth...th.....hhhh.slhlhs..hhhh..hsulshslhllLluhhtspphlhululhshhhhluha.YYpLthoLLhKShhLhssGllLLshthllt+..h................................	0	11	24	39
+14194	PF14352	DUF4402		Domain of unknown function (DUF4402)	Eberhardt R	re3	Jackhmmer:B2KBI6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 182 amino acids in length.	25.20	25.20	26.00	25.60	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.87	0.71	-3.68	65	129	2011-06-10 07:19:46	2011-06-10 08:19:46	1	2	54	0	66	133	13	131.50	20	75.21	CHANGED	lslsps..ss........LsFG........hhsssssGoVsl..sssG....shshsGssshhsssss.....sApFslsG.psspshslols.........sshslss........sssshslsshs.................sshstssthsssG..............stshslGGoL.......sls.usps..sGsYo.Go..asVoVsY	..............................................................plsps..ts........LsFG........hhss.ssssslsl.....sssu.....hs..sssh..hsssss..............sApFslsG.ps...spslslols...............sshslss..........ussshslsshs.................................sthsssshhsssG...................stslplGGoL..........sls..usps......sGsY.o.Go..hslsVsY......................	0	21	42	59
+14195	PF14353	CpXC		CpXC protein	Eberhardt R	re3	Jackhmmer:B2KC69	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea, and is typically between 122 and 134 amino acids in length. It contains four conserved cysteines forming two CpXC motifs.	24.00	24.00	24.00	24.80	23.90	21.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.84	0.71	-4.18	43	128	2011-06-10 07:51:50	2011-06-10 08:51:50	1	3	105	0	30	113	9	122.00	21	47.72	CHANGED	plsCPpCtpphchclhstlssspcsch+cpll.sGplhphpCPpCGpphhl..shshlYpD.p.c.chhl...hhhPc......tphppthphhtshph.........t.tttthphRllhshsplhEKlhIh-sGl-....D+hlElhK	.......................lsCPpCtpthphphh.shlssspcPchppplh.ssphhthpCPpCGpph.t.l..shshlYhD.p..c.chhl...hhsPp...........p.ttpphphhtthp...................htthphRhshshtplhEKlhlhcsuhscchhEhhK......................................................	0	18	30	30
+14196	PF14354	Lar_restr_allev		Restriction alleviation protein Lar	Eberhardt R	re3	Jackhmmer:B2KDC9	Family	This family includes the restriction alleviation protein Lar encoded by the Rac prophage of Escherichia coli, Swiss:P33229. This protein modulates the activity of the Escherichia coli restriction and modification system [1].	28.60	28.60	28.60	28.70	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.92	0.72	-3.67	63	206	2011-06-10 08:38:13	2011-06-10 09:38:13	1	6	176	0	44	148	11	60.10	35	47.56	CHANGED	tcLcP......CPFC.Gssslthps.......ppt.t.............................hhlt..........Ctp......C....Gu.................tsshtpscpp....AlctWNpRs	...............cLKs......CPFC.Gssplhlcs.......s.shs.....................................hhsc...Cst.......C....tu....................csshsssttt........AhcpWN+R.........	0	10	24	35
+14197	PF14355	Abi_C		Abortive infection C-terminus	Eberhardt R	re3	Jackhmmer:B2KEQ6	Family	This domain is found at the C-terminus of the Lactococcus lactis abortive infection protein Abi-859, Swiss:Q48620. This protein confers bacteriophage resistance [1].	24.00	24.00	24.40	24.50	22.10	19.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.67	0.72	-4.04	92	373	2011-06-10 09:57:38	2011-06-10 10:57:38	1	2	341	0	82	267	10	78.90	23	29.98	CHANGED	lspLh..phspptLshtsspttp..........t.hppll...sultsll........pulsslRN.ctu.suHG.....ts....pthtlsspcAcLslssusolst.allcs	....................................................h..pLh..ptshphlthp.ppp.t..........p.l+pll....puhssll....sulsplRN.ctu..suHG.....pst.....pthtl.s.pcc.AcLslssusolstalhc....	0	18	51	68
+14198	PF14356	DUF4403		Domain of unknown function (DUF4403)	Eberhardt R	re3	Jackhmmer:Q8KCF8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 455 and 518 amino acids in length. There is a single completely conserved residue W that may be functionally important.	27.00	27.00	46.10	46.00	24.40	22.90	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.13	0.70	-6.18	41	97	2011-06-10 10:29:55	2011-06-10 11:29:55	1	1	88	0	59	107	9	419.20	20	89.72	CHANGED	stshSslslPlpls..lsslpphlNpplstphhspssh.ts....................ptplphplsRtGslslsus....ssplhhohPlpsphphthuhtshh.th.......................shstssphssslshsspsslsssWclssphp.....shshhppsslslu.sh+lslpshlcshlcpthpclpstl-pplppshsL+pplpphWpphpcPl.lsp......s.ssWLclpPpclhss...phsspslphslGlpupspsssus.pPt.....hPLPshphhs..shssphclslssplsas-lsphlspph...ts+sFs...sssh.plplcslplhu.ssc+Lhlsl...pspus.........hcGslalsG+PsaDssspplplpDl-aslcocu.h.Lhpsushlhpstlpctlppph...shslpsplspsppplpptlup..psspslclsuplpslphsclhhsscslplhlpAsGpsslplp	...............................................s..t.ShlslPlpls..lsslpphhsptlstphhtcss..ss....................ttplphpl..h.R.Gslslsss....ssplhhshPLphphphthuhtshh...........................hstssphpsslphsspspls.sWplpsphp.....shshhpssslplu.Ghclslss.lcshlcpthsphtstlspplpcshsL+ppspphWp.phpcPl.lsp........shWLplpPpclhss...phss.sslphslGlpspschssus.pPt.....hslPs.hhths....shssthplslssplsas-lscllppph...tu+sFs...........ssshplplcplslhu..sss+Lllslplpup............hpuslalhGpPhhDstspplplpDlchslcocs.h.Lhpsushlhpstlpptltpph...shslpstlspspppltptlsp..pstpGlplsuplpslplsclthsssslplhspApGplplpl........	0	21	40	52
+14199	PF14357	DUF4404		Domain of unknown function (DUF4404)	Eberhardt R	re3	Jackhmmer:Q8KFC4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved residues (P and G) that may be functionally important.	27.00	27.00	27.00	27.90	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.83	0.72	-3.57	40	107	2011-06-10 10:45:52	2011-06-10 11:45:52	1	1	105	0	38	91	6	83.50	38	92.69	CHANGED	cLpppLppL+ppLp...psss.lD-sppstLpsLtc-IpphLpp...tsssttpcpsls-plsp.Alp+FEscHPpLutslcplhsoLusMGl	...........pLpcpLssLRcpL-...psss.ls.Epp+tpLcpLhppIEtplp........tstt..p-soLsDslNh.AlERFEspHPsluuTLRsIlpoLusMGI.	0	9	17	30
+14200	PF14358	DUF4405		Domain of unknown function (DUF4405)	Eberhardt R	re3	Jackhmmer:Q0F3T2	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There are two conserved histidines that may be functionally important. This family is N-terminally truncated compared to other members of the clan.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.14	0.72	-3.84	112	320	2012-10-03 10:28:09	2011-06-10 13:45:22	1	10	262	0	150	342	33	63.50	23	31.21	CHANGED	lphhlshhlhlshlhlhloGlll.hts.shh........hhuhstthhc.plHhhsuhhhhlhhslHl.hlpW	...........phhlshhlhlshlhhhlSGlll.hhs.shh......................hhshs.phhp.pl.HhhsuhhhhlhhslHl.shpW.....	0	53	92	121
+14201	PF14359	DUF4406		Domain of unknown function (DUF4406)	Eberhardt R	re3	Jackhmmer:B2KDC7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 98 and 145 amino acids in length.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.10	0.72	-3.91	41	334	2012-10-02 19:28:18	2011-06-10 13:54:17	1	3	282	0	34	299	91	89.40	37	77.64	CHANGED	lYIAGPMo..Ghs........-hN+ssFppsAccL+tpG...ahVlNPAph......Pssh.......s......acpYM+lslshLh.sCD..sIhhLsGWppScGAphEhtlAcpLGhplhht	..........................................................hYluGsMo....Gh...........saN+..AFp.p.stptL......+....p..cG....asV..l..NPAhh.............s-uh.......s...........scYM.c.hshshLp..ssD..sI.Y.h..L..p..GWppStGAptElslAc+LGhsVhh.t...........	0	12	23	30
+14202	PF14360	PAP2_C		PAP2 superfamily C-terminal	Coggill P	pcc	Jackhmmer:Q56Y01	Domain	This family is closely related to the C-terminal a region of PAP2.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.79	0.72	-3.71	54	511	2012-10-02 00:53:37	2011-06-10 14:41:37	1	8	174	0	334	550	26	72.40	38	19.26	CHANGED	tCGDllaSGHThhhslshhhhhcY....ssphh........h+hlhhllshhshhhIlhu+tHYTlDVllu..halsshla.hhYHt	....................hCGDhhFSGHTlhlslhhhhlpcY.............ss+ph.........................h+hls.Wllshh...u.hhhIlsu+..cHYolDVllAaYlostlF.hhYH................	0	123	175	264
+14203	PF14361	RsbRD_N		RsbT co-antagonist protein rsbRD N-terminal domain	Eberhardt R	re3	Jackhmmer:Q8KAB8	Family	This domain is found at the N-terminus of a number of anti-sigma-factor antagonist proteins including B. subtilis RsbRD, Swiss:P54504. These proteins are negative regulators of the general stress transcription factor sigma(B) [1]. It is found in association with Pfam:PF01740.	23.00	23.00	24.10	24.10	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.06	0.72	-3.58	74	220	2011-06-10 14:14:43	2011-06-10 15:14:43	1	6	201	0	98	227	5	103.70	21	39.90	CHANGED	slt..clLpc...ccpplLppWhpph.tphstcssth.ptc.hpp.ssslhpsltpulpsh.......hDhhssph......pplpphLssls+hRAhQGFoPscsssalasLKpslhchlppp	.........t.h.phLppccptllppWhcth.tp....hs....hp..sst.h..c.pc.hcppspslhpslspulpps..........hchtsssh.........splcphLsp...lu....+sRAhpGFoPscssshlhuLKpslhphltt............................	0	39	65	88
+14204	PF14362	DUF4407		Domain of unknown function (DUF4407)	Eberhardt R	re3	Jackhmmer:Q8KC28	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.	28.30	28.30	28.90	29.00	27.60	28.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.66	0.70	-5.46	54	204	2011-06-10 14:37:50	2011-06-10 15:37:50	1	6	166	0	93	182	38	296.40	23	61.13	CHANGED	s.slLcp.sss-psKasulGAslhhTAlhAsluuuaAlhhshsss.............hhulhhG.llWGlhIhsLDRaIVsohp+pst...............hhpphh.uhPRlllAlllulVIScPLpL+IF-pEIsppltptppppttphhsplss...........................thssphsthpsplsslppphsptpsplsthhpthpsEhpGs............ssoshhGhG.shhcp+ppphcstt.......splpslpsp...ssthsthc......................pphsphptsppthhsppp.t....sstsGlhsRhpALscLs.....tts..hhhsphhlhLLF.lulEhhPllsKLhsstus...YDhtlppp-pt	.............................................t..........t-cspasshGshlhhsuhhA.slsuuhA.l.tts....hpss.........................hhul.hu.llhGLhlhsl-Rhlso....u.t+tps.....................................h....h..t..sss..RhhlAlhlu..hVluc.ltLhlFp..spIs...pclpcp.t.pptpst.stlps..................................................ssplpphpsth...ssLcsplpptcsclspth..shhpsEhpss.................ptoGhsGtG.P.scptpphh.sstp...........................................tcLsshhsp...hspptstlc...............................................pptptltpsppt..hhst..............sstpGhhsRh.AhscLs......ts..s..hhhsphhhhhhh...hhlthhPllh+Lhpstss...aDhthttpt..p........................................................	0	31	59	77
+14205	PF14363	AAA_assoc		Domain associated at C-terminal with AAA	Coggill P	pcc	Jackhmmer:Q9M0V8	Family	This domain is found in association with the AAA family, Pfam:PF00004.	22.10	22.10	22.10	22.50	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.34	0.72	-3.94	102	409	2011-06-10 15:51:54	2011-06-10 16:51:54	1	12	26	0	238	417	0	98.40	24	20.91	CHANGED	hlP...t.p....lcp.....h.....l....t...shhtph.........hs....th.hss.hh.slsIpEhs.....u...........hp....pN............c.............hapAscsYLusph..ssp.....s....c+L+sspsc...pspt...................hslolcc.s-clsDsFc.GlclhWphsspp	..........................hP..plpth.....l....h.....phhtph.........ht....h...hs.shh.plslpEhs.....u...........hp.ps............c.................hapAspsYLu.s.p.s..ssp.......s....c+L+..sstsc.p.sps...................lslshcc..s-clsDsF.....p.....Gspl.hWphh...p...............................	0	25	137	200
+14206	PF14364	DUF4408		Domain of unknown function (DUF4408)	Coggill P	pcc	manual	Family	This domain is found at the N-terminus of member of the DUF761 family Pfam:PF05553. Many members are plant proteins.	21.50	21.50	21.50	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.57	0.72	-4.39	37	166	2011-06-10 15:57:58	2011-06-10 16:57:58	1	2	20	0	93	164	0	36.80	33	13.20	CHANGED	hPplaushtua.............lsPshL.FlllNll...IhsIsupS+h	.....................................hhsshtsa.......................hoPshL.FlllNlI...IlsIssoS+h..	1	11	54	74
+14207	PF14365	DUF4409		Domain of unknown function (DUF4409)	Coggill P	pcc	Jackhmmer:O64569	Family	\N	23.90	23.90	23.90	24.10	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.73	0.71	-3.92	35	420	2011-06-10 16:12:37	2011-06-10 17:12:37	1	21	28	0	255	418	0	104.60	32	27.44	CHANGED	oIpSPD.GDlIDCV.hp+QPAFDHPhLK....s..hp....hcPs.p.pPcuhh.tc........p....p...........ppps.....spshsQlW+psG.c.CP-GTlPIRRTpc-...DlLRA..sSlp+aG+Kpppsh..sts.p..t..ss..hspsGHcHAluYs	.....................lpo.D.GDllDCVshpcQPAFDH..P.hLK..........s...hp......hcPs.....hPpsht.tp........................................ttt......tp.hhphWp.pss...p.CPcGTlPIRRs.pcc.......DllRs....p....S....ht....phsh..+..t.................................................................................................	0	51	132	159
+14208	PF14366	DUF4410		Domain of unknown function (DUF4410)	Eberhardt R	re3	Jackhmmer:Q8KCX4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 238 amino acids in length.	26.00	26.00	26.00	26.10	21.60	25.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.53	0.71	-4.43	38	82	2011-06-13 11:52:46	2011-06-13 12:52:46	1	1	73	0	41	82	7	130.50	18	64.47	CHANGED	lhVtsF...thpstth....t...........................ttstpppppstphscphusplspc.Lppp..ulhutpsssss....tsslllcGshtphctGspttRhhlG.hGA...Gpoplpsslplhs..................soG+hsuth.ssssssuuu	..................................................................................t...........................ptttp.ppphtt.hcphtpplhppLppp...slhsttsssss.....tshhlpsplpshchGssttRshlG.hGA...Gpsplsuslplh-..................sss+..sthpsssshuhuu...................	0	8	17	33
+14209	PF14367	DUF4411		Domain of unknown function (DUF4411)	Eberhardt R	re3	Jackhmmer:Q8KAB2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 153 and 170 amino acids in length. There is a single completely conserved residue D that may be functionally important.	23.50	23.50	23.70	23.50	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.13	0.71	-4.53	58	237	2012-10-03 20:43:45	2011-06-13 13:14:28	1	1	225	0	61	213	14	150.70	26	96.66	CHANGED	Yl.LDoNlhI..putppaYs.h-lsPuFWchLpphhp..sGplhohcpVt-Elpps.....sD-Ls.pWscppts...hhpss-...tshpphtplhpa....psspaptss....ttah.......shADsaLlAtAhs.pst.....slVTpEt......tsstpp............phKI.PslC..pthsVphhshaphl.+chshpF	............................................................Yl.hDosshl...........puhpphYt...shhsuhWphltphhp..ssplh..shctVtcEltpt.............sDchp..cWhctpts..........hhhs...t-........tph.pthtclhph....sppthppt...................ptADsalIAhAhs..pst...........slVTpEpt..........sss.pp............th+I.PslC..pth.s..V...hlshhphl.cp.shp............................................	0	23	39	52
+14210	PF14368	LTP_2		Probable lipid transfer	Coggill P	pcc	Jackhmmer:O49645	Family	The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.36	0.72	-11.38	0.72	-3.85	72	1249	2012-10-01 19:46:35	2011-06-13 13:37:29	1	18	64	3	722	1872	6	97.10	20	61.47	CHANGED	hlA..h..hhsssts...s....sss....................sssssC.......sss...hh...ss............hs...h.........hs.....s...s...ssPsssCCssl+s..h.....h.t.sp..ssClCthhss.s..............ts...h.sls.hspuh.tLs.ptCsls..sss.....tC	.................................................................hhh......................ts..........................ss.s.s.sC........ssp.....Lh...ss.................hs...h.........ls............s.s.....ssPossCCsslcs..h....................t......ss...........tCLCthlpsss...........................hs..h.sls.h.s..pAh.t.l.P.stCslsss......C..................................	1	104	420	582
+14211	PF14369	zf-RING_3		zinc-finger	Coggill P	pcc	Jackhmmer:A0MEB9	Domain	\N	29.60	29.60	29.60	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.18	0.72	-3.95	96	381	2011-06-13 12:47:51	2011-06-13 13:47:51	1	8	114	0	221	364	0	33.60	39	9.85	CHANGED	spYWCapCsphVpl..t..tss........s...CPpC.s.u.GFlE...El	...paaCapCsp.Vph..t....ssh.......h....CPpCp.u.GFlEEl....	0	46	116	169
+14212	PF14370	Topo_C_assoc		C-terminal topoisomerase domain	Coggill P	pcc	Jackhmmer:B3H4K2	Family	This domain is found at the C-terminal of topoisomerase and other similar enzymes.	25.00	25.00	27.80	27.80	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.40	0.72	-4.32	47	743	2011-06-13 13:44:24	2011-06-13 14:44:24	1	10	600	16	275	707	30	65.80	64	12.18	CHANGED	lcc+lcphplphpsK--NKpVALGTSKlNYlDPRITVAWCK+a-VPIEKl.FoKTLRc....KFsWAhcs....cpcap....F	....................L.c-QLhKLElQtTD+.....-ENKslALGTSKLN...YLDPRISVAWCKKa-VPIEKI.aN.......KT.R-..................KF.WAht.........................	0	90	146	221
+14213	PF14371	DUF4412		Domain of unknown function (DUF4412)	Eberhardt R	re3	Jackhmmer:Q8KCD3	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.	28.70	28.70	28.90	28.80	28.30	28.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.94	0.72	-3.47	91	199	2011-06-13 13:44:51	2011-06-13 14:44:51	1	7	134	0	99	199	11	89.20	21	35.07	CHANGED	hpchG.scslsGhpCp+hcl................tssptptph...Whop-...............................................tGhPlchptpsssssh................htslchpsh.ssuhF..plPs.GYp	..........pchG.scslsGhsCpcaph.....................tssptpsph...WhopD...........................................................................................Ghslphptpssss.s...t.......................hhplphts..ssuhF..plPs.GYp....................	0	51	80	93
+14214	PF14372	DUF4413		Domain of unknown function (DUF4413)	Coggill P	pcc	Jackhmmer:	Family	This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.	27.00	27.00	27.00	27.00	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.38	0.72	-4.03	79	377	2011-06-13 14:32:42	2011-06-13 15:32:42	1	27	37	0	208	358	0	97.30	25	17.07	CHANGED	lSusphPTuNhaapplhclct.......hL.pc..h.p.sp...-.s.h.lp.s.hspsMppKFcKYW.......c......phshh....LslAslLDPRhKh....p.h...lcathpph...aGp...c.sp...ph...l.pcVcsslpcLappYp	.......................................................ss..sTus.hhh.phhplph..........................hL...pp...h...t..sp.......s..h.lp.s..hsppMpp.......KFcKYW..........................p............phshh....lslAslLDPRaKh....c.h...lcathpph......hut....c...st...ph...lpplpptlpplappY..................................	0	9	80	136
+14215	PF14373	Imm_superinfect		Superinfection immunity protein	Eberhardt R	re3	Jackhmmer:Q8KCM5	Family	This family includes the E. coli bacteriophage T4 superinfection immunity (imm) protein, Swiss:P08986. When E. coli is sequentially infected with two T-even type bacteriophage the DNA of the superinfecting phage is excluded from the host, into the periplasmic space. The immunity protein plays a role in this process [1].	27.00	27.00	27.20	27.20	26.80	23.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.03	0.72	-4.32	60	264	2011-06-13 14:42:33	2011-06-13 15:42:33	1	5	229	0	62	205	39	42.80	40	38.53	CHANGED	lYFlPsllAhhRp..+ppthsIhllNlhLGWThlGWlsALlWAlp	..........lYFLPsllAhtRc..+psphsIhllN....lhhGWThIGWllsLhWuh.........	0	17	30	48
+14216	PF14374	Ribos_L4_asso_C		60S ribosomal protein L4 C-terminal domain	Coggill P	pcc	Jackhmmer:Q9C6F1	Domain	This family is found at the very C-terminal of 60 ribosomal L4 proteins.	27.00	27.00	27.20	28.20	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.60	0.72	-4.10	64	472	2011-06-13 14:55:20	2011-06-13 15:55:20	1	6	336	8	266	449	5	78.60	42	21.13	CHANGED	psYpLPpshhsNsDLsRlINS-EIQullRsPptpspp+...ltKKNPL+Nhpshl+LNPYAtsh++pplhsppppttt+ttt	......psYsLPpshMsNsDLoRllpSsEIQpslRss.......+ppsp++......shK.KNPLKNhplhL+.LNPYApsh++ptlhtpttphttp...h.............................	0	101	154	217
+14217	PF14375	Cys_rich_CWC		Cysteine-rich CWC	Eberhardt R	re3	Jackhmmer:Q8KFY4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 74 and 102 amino acids in length. It contains eight conserved cysteines, including a conserved CWC sequence motif.	24.00	24.00	25.10	25.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.19	0.72	-4.04	76	321	2011-06-13 15:01:50	2011-06-13 16:01:50	1	4	317	0	117	296	51	50.50	33	57.01	CHANGED	CPhCGsshpCu...........ttstssCWCsshshs.shh......tth.t.......................psClC.sCLpph	.........CPtCGpshpCs............tss.tsCWChs..hshtsshh......tth.tth.....................psCLC.pCLpp.h..	0	25	54	87
+14218	PF14376	Haem_bd		Haem-binding domain	Eberhardt R	re3	Jackhmmer:Q8KBS9	Family	This domain contains a potential haem-binding motif, CXXCH [1]. This family is found in association with Pfam:PF00034 and Pfam:PF03150.	27.00	27.00	27.40	37.50	26.80	25.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.79	0.71	-4.48	89	710	2011-06-14 08:17:18	2011-06-14 09:17:18	1	4	650	0	123	370	30	137.10	48	34.47	CHANGED	llshlslQhhshpps...........ssshtp.hpsspplptlhcpuChDCHSspTpaPaYuplsPsuahlppclpcG+cphNhopatsh...........spptppscLsclhphlcpscMP.tpY..hh..hH.pAcLopp-+ptllsWlpptp	.................................h.lsYLGLuGYVaaaDppRucp...ucspu...SsluENsclluhl+EKGCDYCHTP.S.A.ELPh.YhhlPsAKQLMDYDIchGhKu..F....NLE..sVcuAL........hsspPVspS-L..sKIEhVhphpTMPPoRY..sA..L..HWuu+lSD-ERs-ILsWIucQR......	0	33	82	109
+14219	PF14377	DUF4414		Domain of unknown function (DUF4414)	Coggill P	pcc	Jackhmmer:	Family	This family is frequently found on DNA binding proteins of the URE-B1 type and on ligases.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.90	0.72	-4.13	25	383	2011-06-14 09:48:55	2011-06-14 10:48:55	1	45	242	0	276	400	2	103.50	29	3.48	CHANGED	IDPsFLtALPE-lRcEVltppls............t..p...sssspsss-lss...........EFLsALPs-IppElLpQEptpppRppppttsp..............ss-MDsAShlATlPPsLRcpVLh-psE	......................lDPpaLsALP-DlRpEV...ltpp..ht.ptsp.................t..p.......sss.....ss...t..ss-lsP.........................................................EFLsALPs-lppElLtQpptppp.ppp...ttttt............................................................hD.sshh.sh...tlRtthh.........................................................	0	75	144	227
+14220	PF14378	PAP2_3		PAP2 superfamily	Coggill P	pcc	Jackhmmer:Q9LVZ7	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.27	0.71	-4.78	12	684	2012-10-02 00:53:37	2011-06-14 15:22:55	1	10	432	0	300	1471	163	172.80	19	49.31	CHANGED	shslhsh-cslthshptsLpph.lsp+PhL.slhush..sohhhththhhlhashhsc.s+hRshhshhhhhshhullshshh.shPs....phLsst.sF.s.hhshsssuha..th.t.h..............hhPShHsuhAhhsulshh+.hthhthhh.lssshsllhslsllustsHYhlDhssGssluhlhhtL	.................................................................................................................................h.........................h.......h................h...hhshh..Y........h...h..h.....h..h.h.h..h..l.h...h.....h..h...h...t....c....t..p..............h....p....t....h.....h..t..sh.h...hs..s....h..h..uh..l...h...a.h.....ha.P.s.s...PP..............................th.h.............................t.......s......h..............................s....h....h....t..........s......h..s.s.h.......s....h....h...........................t.........h......tth.......................ss.h...s..A...hPSlH....s.u...h....u....l....h..h......u...l.......s.......l..........h.....p.....h.....t...........t.............t.............h.........h..............h...h....h.........l....h.h....h.a.sh.h.h.hh..s..sls..s..upHYhlD.s.lu.Ghhhshhh...hh......................	0	97	194	260
+14221	PF14379	Myb_CC_LHEQLE		MYB-CC type transfactor, LHEQLE motif	Coggill P	pcc	Jackhmmer:Q9LG13	Family	This family is found towards the C-terminus of Myb-CC type transcription factors, and carries a highly conserved LHEQLE sequence motif.	27.00	27.00	29.00	29.00	26.90	26.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.69	0.72	-4.38	46	474	2011-06-14 14:51:50	2011-06-14 15:51:50	1	10	53	0	259	459	0	49.60	52	15.20	CHANGED	uhpls.EALc....hQhEVQ++LHEQLE..lQ+pLQ.lR.I......EupG+aLppllEctpcshu	...............hpls.EAL+........hQMEVQ++LHEQ..LE........VQRpLQ.LR.I.......EAQGKYLQpllEctpch..s......	0	43	156	213
+14222	PF14380	WAK_assoc		Wall-associated receptor kinase C-terminal	Coggill P	pcc	Jackhmmer:Q5XVH3	Domain	This WAK_assoc domain is cysteine-rich and lies C-terminal to the binding domain, GUB_WAK_bind, Pfam:PF13947.	27.00	20.00	27.00	20.20	26.90	19.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.86	0.72	-3.48	53	366	2011-06-14 15:07:24	2011-06-14 16:07:24	1	27	20	0	205	376	0	92.30	23	22.47	CHANGED	hsCssps.....s..st.....sh.hh...h........s...s.................s....s.........hsttCppsltlPVhssth..tt.tt.......ssss...htpsLcpGFpLpWp......tsssCppCts........SuG.pCGasps.........s.ptFsChCsDsh	...........................................................................................................t.....h.ttC..p.....h.lPV...tt..h.t..t...........s.ss....htpsLppGFpLpap.....sssCppCps........S..GG.tCGasps...........t..tta.tCh.Csst...................	0	22	113	156
+14223	PF14381	EDR1		Ethylene-responsive protein kinase Le-CTR1	Coggill P	pcc	Jackhmmer:	Family	EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation [1].	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.55	0.71	-4.75	46	364	2012-10-10 12:56:15	2011-06-14 16:27:23	1	45	119	0	219	341	1	179.40	30	21.50	CHANGED	sssu-slSpRaWspssLsY...t-KlsDG..FYslhGh........t.....pts+hPSLpsLcuhs.s.s..ssshEllLVDRptDspLpcLcphAhsls......pss.....ss.ss.....ptllp+LApLVsspMGGssts.sps.hhs....p.Wpp..op...L+s...ppusls..lGpLslGLsRHRALLFKVLADsl.....slPCRLVKGs..su..........c-suhslV+hs.s....sREalVDLhusPGsLh.P	........................................................................................hu..hh..s..ls.....p.l.sG..FY.lhs...........................................phPsh.pL...pt......tt.th-slllst...D.tL.t.l.phs.t.hh..........................ts..........ss.....tthlppLAplVscpMG...........Gss.....s..tp..hhh........pap....hSp......ph+p.........psssls..lGplp....hGl.sRHR.ALLFKlLADpl.......s..l.PC+LV+Gphhsu..............pstshsllt..ht.s..............sp...E.....alVDLhttPGpLh....................................................	0	41	119	175
+14224	PF14382	ECR1_N	ECR11_N;	Exosome complex exonuclease RRP4 N-terminal region	Coggill P	pcc	Jackhmmer:	Domain	ECR1_N is an N-terminal region of the exosome complex exonuclease RRP proteins. It is a G-rich domain which structurally is a rudimentary single hybrid fold with a permuted topology.	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.74	0.72	-4.66	79	613	2011-06-14 16:29:30	2011-06-14 17:29:30	1	16	360	11	439	594	35	39.40	35	14.59	CHANGED	lllPGp.hLus.s.s.pa.h.s.GpGTYh......cs.splhASlsGhlplss	....llsPG-.hls......s.s.s.p.....a.h...t.GcGTYh.......................ps..s......plhuSluGhVph.......	0	131	226	350
+14225	PF14383	VARLMGL		DUF761-associated sequence motif 	Coggill P	pcc	Jackhmmer:Q1PFF9	Domain	This family is found frequently at the N-terminus of family DUF3741, Pfam:PF12552.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.56	0.72	-4.78	10	212	2011-06-14 17:36:40	2011-06-14 18:36:40	1	5	19	0	148	189	0	29.80	43	3.81	CHANGED	suosssscuhuh+uPulVARLMGLDSlPssppsp	.........t...............+sPulVARLMGLD.uLPs............	0	20	93	122
+14226	PF14384	DUF4415		Domain of unknown function (DUF4415)	Eberhardt R	re3	Jackhmmer:Q8KF70	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 82 and 104 amino acids in length.	26.10	26.10	26.10	26.30	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.08	0.72	-3.81	196	801	2011-06-15 08:14:51	2011-06-15 09:14:51	1	2	572	0	237	649	74	66.50	32	69.83	CHANGED	Dhsphsct...tpht..............................................Kp.p..lolRlDsDV.....lcaF+u..p.GcG......aQo+lNtsL......Rchh	.................................................-.s..sct.h.tpAp.ht.....................................hhpPh.....sKp.p..lolRlDsDV.....l-aF..Ku.....s..GcG......aQoRlNthLRchh..............	0	53	137	182
+14227	PF14385	DUF4416		Domain of unknown function (DUF4416)	Eberhardt R	re3	Jackhmmer:C9RKS1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved DPG sequence motif.	27.00	27.00	43.60	96.40	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.83	0.71	-4.53	29	85	2011-06-15 09:02:56	2011-06-15 10:02:56	1	2	82	0	53	88	19	163.40	33	87.51	CHANGED	tst.spLlh.slhss...pphhpp..lhttLpc+FGsl-hhSs.hsFc.aTsYYpcEMG.sslh..++hluFccLls.-pLs-lKlhTNplEppaut.cup....RplNlDPGYlstpplVLAosKsasHRlYLscGIaA-lTLhYppGc.apshsWTYPDYpspphtpaLsplRch..Y	.........................h....spLlh.ulh.hs...cthhpp..lhstLpppFGslchhSs.hsFp.aTsYYpc.EMG.ps..Lh..++hluFccLlp.ppLsclKhtosplEcpaup..puc....RplNlDPGYlstpplVLAosKsasHRIYLscGIYAElTLhYpcGc.apshsWTYPDY+spchtpahpplRchY......	0	29	46	48
+14228	PF14386	DUF4417		Domain of unknown function (DUF4417)	Eberhardt R	re3	Jackhmmer:C9RLL4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 220 and 340 amino acids in length. There is a single completely conserved residue G that may be functionally important.	27.00	27.00	31.00	30.60	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.13	0.71	-4.98	22	148	2011-06-15 09:37:46	2011-06-15 10:37:46	1	2	121	0	11	123	1	194.50	25	76.35	CHANGED	pll.p................h.hsuphclPhlt.sphhsts................hlsFshtpppcp.....................pstslHFalcDhpFcclassPc.......phlppLpp..apulloPDaSlYhDhPhshQlaNhYRs+hlutahQppGlpVIPslsWuspcoa.......casFcGl.sctuslAloohG.....phpspcpcphFhpGhpchlp+l.pPtplllYG....th..pphass.....hpllphpsatpp	...........................................................p.......h..psthplPhlp.sphhs.t................hhsashhtpp.p...............................psshlHFahcDhpFcp...laspsc.......phlpclpp.......asullsPDaSlahD......hPhshplaNhY+sRh.lutahQ.ppGlpVIPslsWuspcoa.......casFcGl..ctuhh..AluohG.....hhpsppphphahpGlpchlc+l.pP.phlll.YG.....th..c.hatp..t..hphhph.sh...p...........................................	0	6	9	11
+14229	PF14387	DUF4418		Domain of unknown function (DUF4418)	Eberhardt R	re3	Jackhmmer:C9RQ28	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 132 and 150 amino acids in length.	27.00	27.00	43.30	43.30	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.07	0.71	-4.38	32	145	2011-06-15 10:24:38	2011-06-15 11:24:38	1	1	133	0	26	122	2	125.30	29	87.92	CHANGED	hl.lllGlLlslsPhh.hhslCss..h.tst..................hMtCaasupAhhslGsllhllullhhhh..ppthchuLslsshshulls...hLlPshl...............IGlC.ttstMtC+sh.ohPslhllullhllhuhhs...hahpcc	..........h..tlllGlllsluPph.hAssCts..h.pst.....................................hMtCaaoupushslGllIhllullhlhl..sttl+huLsluslslulhs...hllPssl...............IGlC.ttstMpC+sh.ThPhlhllullhllhusls...lahpp.p.......	0	17	19	22
+14230	PF14388	DUF4419		Domain of unknown function (DUF4419)	Eberhardt R	re3	Jackhmmer:C9RQB5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 348 and 454 amino acids in length.	25.00	25.00	26.90	26.70	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.12	0.70	-5.20	59	188	2011-06-15 10:35:06	2011-06-15 11:35:06	1	7	78	0	151	195	7	271.50	28	70.40	CHANGED	ssuFlpu.shpAYupHhsLhlpPD-lWhsIlsphuhalsspu..EpLRphFVsa.cGKcpLhVp....stssh.p..............sasplh.chsppIpcpltss.h....cchhh..s.sFSTTTtsD+lsuslshMush+pYFcYp.......hhhhCGlPs..........VTLLGph-DWppLtp+lc+Lt-.....as.p..............hppWt.phLpPllccFlpohcsps....s.......hpFWspIschpus...uuGssh..l......oGWIosFhhasp..pGphhttttt............................................................ts.h.hlshpplPsGhsplPlplp...s.stt...hptphhuGhhGhph.....ppp............................psslpPthsWhlh	...................suhlpuhhpAYspHptLhlcPD-lWhsIhpQhshal....Ntpu..E..plRphFVsa..pG.KcpLhVp........ssh.p..............satthh.phsppI.pppltss.l.......tshlh...P.sFSTTTtsDphsuslhhMu.sh.ppYFpat.........hhhhCGl..Pp..........lTL.GphpDWtplhp+lccLt-.......as.t...................hptWh.phLpPllcpFlpuhcsss........s............hpFWpplhchpst...........huGssh.....l.....sGWl.ssFhhaspcGph.t..................................................................................h.hls......hpplPsuhspsslhhp...p..t......h.h.hhuGhhGhph.....pp............................t.slpP..sWhh.............................................	0	78	120	139
+14231	PF14389	Lzipper-MIP1		Leucine-zipper of ternary complex factor MIP1	Coggill P	pcc	Jackhmmer:A8MS81	Family	This leucine-zipper is towards the N-terminus of MIP1 proteins. These proteins, here largely from plants, are subunits of the TORC2 (rictor-mTOR) protein complex controlling cell growth and proliferation [2]. The leucine-zipper is likely to be the region that interacts with plant MADS-box factors [1],	26.00	26.00	26.00	26.40	25.80	25.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.98	0.72	-3.88	39	340	2011-06-15 10:44:33	2011-06-15 11:44:33	1	11	25	0	185	326	0	83.90	31	13.80	CHANGED	pcpps.p..pp+t....sLEp-VtpLpcpLpcEpslRtsLEpAlsp.......ssus.hsp.hst.plPppspELlpEIAhLEt-VspLEppl.sLttplhppp	.............................t......ppt+.sLpp-.VppLpcpLp.pEpsl+tuLEpA.hst.....................s.us...hsp...ss..hlPspsp-LltElAlLEtEVs+LEppllsLppplhpp...................................	0	35	109	149
+14232	PF14390	DUF4420		Domain of unknown function (DUF4420)	Eberhardt R	re3	Jackhmmer:C9RS82	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 310 and 334 amino acids in length.	27.00	27.00	33.00	32.70	19.40	18.60	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.77	0.70	-5.58	41	142	2012-10-11 20:44:47	2011-06-15 11:48:59	1	1	139	0	58	155	70	293.10	20	92.56	CHANGED	pplpphWpplptp........t.thstphlptstt.hslhluhshpsphthhl..............hshthhsphsphpuhc.lp.......t.tttphhlslphpsss.hpclFstlssDllppl...t.pstpphhpshhtplpcWpcLht..tttpslopcp.hGLhGELhhLcp..h.sthsspts..lpuWsGPptsppDFphss..sslEVKooh..psspplpIou.cQ.L-ssstt.....LhLshhtlppsss....Gh.olscllsclpphl...t..tshptapp+Lh.phGYh.tpt....htphpatlpphch.apVc-.sFPRlspss.....lP.pulsslpYpl-Lss	...........................................................................................................................t............................hh......hthhhuhs...s.p.thhh.....................tph.sphpshp.lth................tttthhltlhh.tptt....tclFttlspsllppl.......tstpphhpshhpplppWpplht..tttptLspcp.hGLhGELhhLcp...l....tthsssss...lpuWpGP..ptsp....pDFphss..tslEVKooh..p..pspplpIuu.cQ..Ls.sstss........LaLhshplppsss....Gh..oLs....s...llpplpptl...ttspshptFpptLh.phGahstpt....htptpa....tl.ps.h....ph...apVs.c.sF.P+lspss......lP..pulsslpYplsLs.t................	0	17	45	52
+14233	PF14391	DUF4421		Domain of unknown function (DUF4421)	Eberhardt R	re3	Jackhmmer:C9RSA4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 336 and 370 amino acids in length.	27.00	27.00	27.40	27.10	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.69	0.70	-5.22	31	119	2011-06-15 10:56:27	2011-06-15 11:56:27	1	1	103	0	25	121	5	295.50	33	84.70	CHANGED	sphDTs...........YIcspcas.hshhlpssssh.Ehaplsssp................tpslshsPsssh+lGshhuaRala........LGaohshptlt.tppspspppphslsL....Yos.+lulDlaY++ssu.Yphpphphts..t..s....shsF.sshpsphhGhNlaYIFNp+.+FSYsAAaSQSshQ++SAGShlhGhuastaplphshstlst.hppp..h................ththpphcahshslusG..YuYNWVFu+.salhss..SlssuluYp.sh.php.pp.tt.sshphpshshchluRhGlsaNss+aauGhShlhcsasYpcpsao....ssshF...GslslYsGa.....pF	...........................................................................................................t.phDTs...........YIpPp+YN.aslMlppsssa..EhYplsspp.................QplsFuPsssh+..lGhYFGWR..WIF........LGaolDlsplh..pppcs+tp-hsLSL.....YSu.clGlDlaYR+TGssY+l+phphhs...phssp.....stsF..sGlpsph+GhNlYYIFNp+.+FSYPAAaSQST.QR+SAG...ShlsGhuhopHpLshDaspLsthlppp..ht........................shthpclKYsshulssG..YuYNWVFA+.Na.Lhsh..SLssuluYKts.h...ph...pppp....sphhhp.shNh...DhlsRhGlVYNss+aasGhShlh+sYsYc+s.sFS....hsNhF.......GslplYsGaNF..........................	0	15	24	25
+14234	PF14392	zf-CCHC_4		Zinc knuckle	Coggill P	pcc	Jackhmmer:Q9SHW6	Domain	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. This particular family is found in plant proteins.	27.00	6.00	27.00	6.60	26.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.58	0.72	-4.29	79	629	2012-10-03 11:39:54	2011-06-15 13:56:05	1	98	80	0	325	3156	20	38.20	30	8.98	CHANGED	lcls+PLpptltlp....hs...ss...p.p..th...hplcYE+lspa.ChhCGhlGHspp..pCst	...............................................................................h.h.YEhh........h..Ch.pCsthGHstp..pC........	0	67	167	281
+14235	PF14393	DUF4422		Domain of unknown function (DUF4422)	Eberhardt R	re3	Jackhmmer:C9RPD5	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 255 and 371 amino acids in length.	25.00	25.00	29.50	29.50	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.66	0.70	-4.76	90	376	2011-06-15 13:10:07	2011-06-15 14:10:07	1	7	289	0	76	365	474	224.80	37	67.37	CHANGED	+IhlusHKphp.hP..pc.shYhPlpVGss.t...............p...........sahtDsoGD.NISp+NPtYCELTulYWAWKN...h.csDY.lGLsHYRRaF....shppp......................tthptllsppplpphl..p.pa..DlllP...c+Rp..ahlc..........olhsHYtcs.Ht.tccL-hscclIpcpaP...-Yhsua-plhpppp.uah..aNMFIM++clFcpYCpWLFsIL.ElEccl..Dh....os.YsshptRlaGalSEpLhsVWlp...p....pp.lc...htE	.....................................pIhlusHKpht...hP...ps.shYhPlpVGtshp....................sh..............shhtDso.....G.D.NISp...+NPhYCELTulYWAWKN....h..csDY.lGLsHYRRaFshppt..........................................tthphll.spp...p.l.pphL...p..ph..DlllP.......c++p.......ahhc..........ohhs...HYtps...Hp...tcsL-hscplIpcpaP...-Yhsua-p..hh.pppp..uah..aNMFlM++chFscYspWLFsIL.clEccl..Dh................os.Y.....sshptRlaGalSEhLhsVWlt....p....pp.h....t...........................	0	23	47	56
+14236	PF14394	DUF4423		Domain of unknown function (DUF4423)	Eberhardt R	re3	Jackhmmer:C9RKJ5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 170 amino acids in length.	30.00	30.00	30.80	31.50	29.80	28.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.62	0.71	-4.72	52	72	2011-06-15 15:22:47	2011-06-15 16:22:47	1	2	5	0	70	73	44	168.50	24	60.39	CHANGED	hhphsptpph+hlsscpacaapsWhpsllRp.Lsshhsss...ssttlActhhstlostclpcuLphLhchullc+sts.ssYtpTppsls.sst-shshul+shp+phhchAhcul-phshpcRshSulThulsccsaccltcplcchR.+clh...sluspp.pc.sccVYpLNlQLFPL	............................h...hhpttph+hlsscpacaappWhpsslRp.Lhshhsss.....ssttlAcphhstlostplccuLphLhchuhlc+sts..spat.oppsls.sstcshshul+shppphhchAtcul-phshpcRshSulThulsccsaccltctlpcFR.+clh...plssps.pp.scpVYpLNlQLFPl..	0	70	70	70
+14237	PF14395	COOH-NH2_lig		Phage phiEco32-like COOH.NH2 ligase-type 2	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A family of COOH-NH2 ligases/GCS superfamily found in the neighborhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis [1].	25.00	25.00	29.50	28.70	20.00	17.90	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.63	0.70	-5.33	8	44	2012-10-02 17:21:26	2011-07-19 19:39:50	1	2	41	0	16	48	0	234.20	36	50.04	CHANGED	osloLGADPEFMLppspGc.MlsAS.cFaspsGslGCDsp+lttc.....hPlAELRPuPspsPcpLltplcplLppAsphlsctslcWlAGuhPasGYslGGHIHFuGl.lohpLlRsLDsYLuLPLhhlEDPss.ttpRRp+YGaLGDaRhKsaGtFEYRTssSWLVSPtsA+AsLpLA+llAcpaccL.ppshhsschpcAFYpG-+chLtsplstlhp-lpuhssYsshtttI-.lashl-cGpoWDEcsDlRptW+IPhh.	.............lhlGhDsEFhLhp.psp.hl.AScah.s+tG.sGsDshphptch....hPlsElRPtPsssPttLhhplpphht.Att..hlsp....psl.WhAGuhPhtsaslG.GHIH..F..S...G.l...........sL.....sh....pLlRsL....DsYLALPLsLlEDsps..thRR.s.pYGhLGDhRtpsaG...GFEYRTLs.S.WllSPtls+uslslAhll..ApphtpLpt...psl.p..phpcAaYpGs.+thL+thh.tlhtcl..thstYtpa...........pt.lt.hhphlcptt.WsEptDlR.hWpl...s............................................	0	10	14	14
+14238	PF14396	CFTR_R		Cystic fibrosis TM conductance regulator (CFTR), regulator domain	Finn RD	rdf	Manual	Domain	\N	22.50	22.50	24.10	23.90	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.44	0.70	-4.97	9	137	2011-07-19 22:39:50	2011-07-19 23:39:50	1	9	75	46	32	131	0	200.10	67	15.53	CHANGED	DFSSpLhGh-uFDpFSAERRsSILTETLRRhSV.DtD..uusshsEsc+QSF+Q.......s.......G...-.....asEKRKsS.ILNPlsSsRKFSllQpu......QhsuhE-ss..cE.sER+hSLVP-sEQGEssLPRSNhh.ssGs.shpu+.RRQSVLsLMTp.S.pQGpphatptsuShR.KhSlsPQssL..SElDIYoRRLSpDSsh-ISEEINEEDLKECFhDDh-shs...ssTTWNTYL	.......DFSSKLMGhDSFDQFSAERRNSILTETLRRFSl...EGDAslSWsETKKQSFKQ...............T..............G.E.....FGEKRKNS.ILNPlNShRKFSlVQKTP.......LQMNGIE.Ess..-EPhERRLSLVPD.SEQGEuILPRuNll.soGP.ThQu.+.RRQSVLNLMT+.Sl.sQGQsl+++ssuSsR.KhSlAPQusL..oE.lDIYSRRLSQ-ouLEISEEINEEDLKECFhDDhEsIP...sVTTWNTYL.........	0	1	3	11
+14242	PF14397	ATPgrasp_ST		Sugar-transfer associated ATP-grasp	Iyer LM, Abhiman S, Burroughs AM, Aravind L	rdf	Manual	Family	A member of the ATP-grasp fold predicted to be involved in the  biosynthesis of cell surface polysaccharides [1].	31.40	31.40	31.40	32.50	31.30	31.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.79	0.70	-5.32	11	400	2012-10-10 13:17:03	2011-07-21 22:10:43	1	5	364	0	135	342	56	268.40	35	78.98	CHANGED	phhhppphtphs.....NspphhtlhccKshasph..hp-h..................hspchhshp....h.p.p-hptahpsp....pplhlKslsG.u.GpGlthhptss......................htpctpslhphhpssc.....pallpEtIpQHpthspLss.sSlNTlRllThhcs..spVclhhsllRhu..tuutssDNhus.GGhhsslDtsus..lpp.A.sh-.ptpta...phHPsotthhssapI..Phaspslphshcsupp.lPplthlGWDlAITspG.PllIEuNss.........sshs......h............ulhs.thsclhshphp	........................................................................................hth.....pRNhsalh+Y..NtR.phYslVDDKlhTK.h...A.p.t.Gh...........................h.hslp....tptplcplpph.....l.tsh.....ssFVIKP.A.p.GuG.GcG.IlVl.s.scptshahp.......ss..hs.pc..lpcc.....l.oshLsGLaSLuGp.......Dsul.lEphlp.cshFpuhSa..-GVPDlRlIl..........h...........pt...........hslhAMhRLu.....psuss.KA.....N.L...H.....Q...G...A...lG...VG.l....D.l.uTG..tlps.....s.........ph...s....p....l.................scH...PDTspplsslpl..PpW-pllpLAusshhE.hsGL.....GYlGsDhVLD.c-.c..GPhlLELNAR.......PGLsIQ.lANst............Glh.............pphtt............................	0	43	84	118
+14243	PF14398	ATPgrasp_YheCD		YheC/D like ATP-grasp	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the ATP-grasp fold predicted to be involved in the  modification/biosynthesis of spore-wall and capsular proteins [1].	100.00	100.00	105.30	105.10	93.00	92.90	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.47	0.70	-5.59	14	572	2012-10-10 13:17:03	2011-07-22 00:11:06	1	7	188	0	184	583	0	256.60	26	65.71	CHANGED	pphppt.th.has.shhsKWcVactLpcppplp.aL.PpTchhpshsslcphlspapplalKPhpGstG+GIhplpptpt...phhschpssptp..p.passhtthhshltpthsppcalhQQulsLhphpG+shDhRshhpKNppGpWploulssRlAupsplsoplssGGpstthpchhs.ct..p.....ppshtppLccsuhpluptl-cthssp....luELGlDlGlDspG+lWllEsNoKPu+pshpp....p..tpppohpp.lpYutaLs	........................................p.......th.hhs.......s..h..h.sK.WplaphLtpstplp.sa.L.PpTphh.pp.h..c...p...lp.phLppa...p.tlalKPhpGohG+GIhplptpp.......s............sahh..phppppp.....t..........hh.php.s.hp.p....L.hphl..p.....p.....h.h...p..t..p.....p.....YllQpG.IsLhph..sGcPhDhRlhspK.s.t.p.Gp.WploulsuRlus.ps.slsT.sl.s..sG.Gp.sth.h.p.phht..p......pc......ttplhpclcch...ulplupt...l-..cphst.....luElGlDlGlD.ppu.plWlhEs..No.K.Pu.+pshp.ph......t.t...p......p.shph.hpYuhaL.............................	0	94	141	147
+14244	PF14399	Transpep_BrtH	BtrH;	NlpC/p60-like transpeptidase	Iyer LM, Abhiman S, Burroughs AM, Aravind L, Eberhardt R	la_psag	Manual	Family	Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases. They are predicted to function as transpeptidases in peptide metabolite biosynthesis [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.78	0.70	-5.14	49	388	2012-10-10 12:56:15	2011-07-24 22:26:28	1	12	298	0	113	426	19	290.20	18	77.47	CHANGED	HCtosshssLL.phtGhtl.....sEshhFGLGuGLsahaht..hhphsh...hlssRst......phhpphtptLGhchp....hpphsssppuhctlcphlspGpsVhlt.sDhaaLsYhss...phHFsuHhlllhGhD..pcphhlsDs.spsshhpss............hssLtpARtupu.........shss+sphathpt....ssshss..ltpslh....pulppsspphlsss...................hGhpGlpphupcl.cW.....tspcphpthhtthhphhcch...............GTGGuhFRtlYupFLpcsuphhst.t.htphuphhpchuptWspl.ushhtphststp...tshpphuchlpplsctEcphhctLt	................................................................................C.sssht.hh.p.hGhth.....s-.hh.hhhstuhsh....hh.......pht....h..hshph........thhpphhph.lGh.php.....hpphs.s.......ppu.....h....p.tlcphLs....pG.hPVhl....t.hDhh..aL..s.......Yh..ss...................phph...............s.............s...HhlllhGhD.....ppthhl..t.....Ds........t...s...h.h...phs............hppltcAhtup.s..............hs..s.tshh.hthph...........st..p......hhptht.....pslpp.shp..phhsss.............................hGhtuhpphsppltp......h.......s.............tpphph.h...hh.......h.hthhtph.......................hR.hh.up.aLpchtt...h........h..p....hup....hhpphuphapth.thhhhc.......t.t.....pthtphuphltplsphEpphhp.h........................................................................................................................................................................................................	0	44	85	99
+14245	PF14400	Transglut_i_TM		Inactive transglutaminase fused to 7 transmembrane helices	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A family of inactive transglutaminases fused to seven transmembrane  helices. The transglutaminase domain is predicted to be extracellularly  located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The  ATP-grasp is predicted to modify the 7TM protein or a cofactor that  interacts with it [1].	100.00	100.00	106.50	106.10	91.80	91.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.88	0.71	-4.73	93	271	2012-10-10 12:56:15	2011-07-24 23:33:47	1	2	269	0	71	210	16	166.30	42	33.13	CHANGED	YRthshGlPhsPGEppplWslEA+lcFsAsGc.Pl+........VohslPphpsuasllsEsssS.sGYGl...........oh..hcsc.s.s..R..+Ap.W.ShRpAsGpQsLYY+splh.s.csps....chs...ths...sP.....................s...hssh.s..h.suP.ppsAA.psLlspspp+SADsho..........FspELI.Kpl.N..sss.sQNspLLLs.s..t....s.+	....aRt.shGlPhTPGETcplWslEA+l-FsApuc.slK........VShusP.pppuasllsEosuS.sGYGl...........Shhps-..u..sRRspW.SlRpA.sGsQTlYY+sphhscspu..cts..phs..ss.....................t.hss.s.h.-uP.EcsAApALlspspp+SADshT.....FspELIKplNssp.sQNspLLLsp......scsp...	0	20	34	56
+14246	PF14401	RLAN		RimK-like ATPgrasp N-terminal domain	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	An uncharacterized alpha+beta fold domain that is mostly fused to a RimK-like ATP-grasp and is found in bacteria and euryarchaea. Members of this family are almost always associated in gene  neighborhoods with a GNAT-like acetyltransferase fused to a  papain-like petidase. Additionally M20-like peptidases, GCS2,  4Fe-4S Ferredoxins, a distinct metal-sulfur cluster protein and ribosomal proteins are found in the gene neighborhoods. Contextual analysis suggests a role for these in peptide biosynthesis [1].	25.00	25.00	31.30	30.40	24.00	19.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-4.71	87	317	2011-07-25 16:00:10	2011-07-25 17:00:10	1	6	294	0	83	259	20	151.70	37	31.83	CHANGED	osp-YLpps....htps...........+...spllNLC+sYpYhopGYYsSLLAEARGH+Vl.PoVpsls-.......LppppLhshshtplp..............................................phltptl.t..p............hssphhplp............laFGps..ptp..slcclARplF-tF.sPlLclphpcppp......................Wplpslps...hslscLscpcpshFtp..uL-	....................osppYLpps....hhst...........+..pspVINLCRsYpYhSpGYYsSLL.AEARGH+VI.PoVpsIs-.......lsptphhphslt.c.lc....................................................chh.p.lpp.............ss-shslp............lYFGps..stcsLccLARpLFEtF.sPlLclphc+pps.......................WpIpsIps.hshpcLp-scp-hFhpuL..................................	0	37	61	73
+14247	PF14402	7TM_transglut		7 transmembrane helices usually fused to an inactive transglutaminase	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A family of seven transmembrane helices fused to an inactive  transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it [1].	25.00	25.00	42.00	41.50	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.98	0.70	-5.50	34	285	2011-07-25 16:28:49	2011-07-25 17:28:49	1	4	280	0	75	224	26	309.70	52	62.39	CHANGED	sphlhpLLspAsIPARhVpuLpLE.Du+RcQplpsalpVass.cc....WhhFsPpoGppGhP-shLlWppustsLL-lpGGpsupVsFShhppphsshphup..pptp.ssp..hhsF..SlasLPlcpQslFKslLLlPlGsLlVVhlRsllGlcTSGTFMPVLIALAFlpTpLlsGllhFlllVulGLllRuYLs+LNLLLVsRluuVllhVIhlhuhlSlluaKlGlspGLolohFPMlILuWTIERMSIlWEEcGs+-VlhQGsGSLhVAlluYLsMssshlpHLsFsFPtL.LllLAllLLlGpYTGYRLsELhRF+shhcs	................................................................s.hhppLLuhAtlPs+hVtsIpLE.DsR...R+Qolp.hlcVasG..pp....WllF.....NPpTGpQ.uhssN.hL.lWppussuLL-VsGGpNSQVpFShlspchss.pssp.....scspsss..hLsaSlauLPLE-QuhFKslhLIPIGALlVVhLRlllGLKTSGTFMPVLIAlAFlQTpLssGIluFlLIVuhGLllRSYLS+LNLLLVuRlSAVIIsVIllIulholluaKlGLscGLoIT...FFPMIILoWTIERMSILWEEEGu+EVhhQGuGSLhsAlLsYLuMosshlpHLsFNF.ulpLllLAhlLLhGpYTGYRLoEL+RFKsLsc-.............................	0	22	37	60
+14248	PF14403	CP_ATPgrasp_2		Circularly permuted ATP-grasp type 2 	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Circularly permuted ATP-grasp prototyped by Roseiflexus RoseRS_2616  that is associated in gene neighborhoods with a GCS2-like COOH-NH2  ligase, alpha/beta hydrolase fold peptidase, GAT-II -like  amidohydrolase, and M20 peptidase. Members of this family are  predicted to be involved in the biosynthesis of small peptides [1].	191.00	191.00	195.90	195.60	187.90	187.50	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.30	0.70	-5.83	6	58	2012-10-10 13:17:03	2011-07-26 05:57:10	1	2	52	0	30	57	2	428.80	25	95.00	CHANGED	LspAlAD.YculL..s.slthtuW.psLstchRuspLhaGsRPlsslh.............RPpllocsQY-lLp+sscplspAlpclspthLsss....ulRphLtLoPhEE+LlshDPGYhtsp.AtuRhDoFLolDGs.LpFVEYNA-SPuuh.AYtDhLAchFlshPshpEFpK+YsltPLPuRphhLcTLLssaRpuGusstcPplA.IVDWpu..sPstoEFEhFpcaFt.......-aGl.sVIsoPp-Lsa.RDGpLls...........GshPlslVa+RllTsEhLsHas...LsHPLVpAYtsGAlslVNSFRAcLlHKKulFALLoDEphcs.hsA--RuAl+sHVPWTRlVpPu.TTapstsIDLlsFAhANRE+LVLKPND-YuGKGlsIGWEsos-tWcpALppAhco.PalVQERVpIshpPaP..thscGcl.ht-h.VDscPaLFG..scVpGChsRLS...TsslLNlos.uGuTlPsFll--	........................h.....................tsa..th.tthctsthhht...sc.s.lstsa.............pPhhhsppshcphpphspplhpllp+lhpchlpss....phRchhshsst.ccLlhhs.GYsthl.shuRhDlFhs..t.ss...hpFsEhNsDuuuuh.scsctlsphhhph.shpcFtcc..aplp.shs..h..hp.hlcphhshYcp.hts.psppPplA.IlDaht...hsshsEFc..hFtchap.......cpGhsshIsssccLpa..csspLhs...........ss.h.lDhlaRRhVTs-llpphs...thcsllpAhtssslshlsSFpupllHsKhlFslLpD-p..spt..h..Lss-EpshIccHlPaTphlps............h-lhphshss+-chllKPsDtYuucGVhlGh-hst-cWcptlpc....shp....p....sallQEahph.s.ppth........th.p.-uc.s.....h.sphhhssu.salas...........tphsGshoRlG...sssllsssh.tshsssshhlp................................................	0	18	26	29
+14249	PF14404	Strep_pep		Ribosomally synthesized peptide in Streptomyces species	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A ribosomally synthesized peptide related to microviridin and  marinostatin, usually in the gene neighborhood of one or more  RimK-like ATP-grasp. The gene-context suggests that it is further modified by the ATP-grasp. The peptide is predicted to  function in a defensive or developmental role, or as an antibiotic [1].	25.00	25.00	103.10	103.00	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.89	0.72	-3.75	7	17	2011-07-26 15:33:21	2011-07-26 16:33:21	1	1	17	0	3	19	0	62.90	72	98.35	CHANGED	MpPFALNYARPAsthpsssPYsYDuuhQLNVLhDGRsAApD+ALLtclGTTTSTAGSKTHFDD	MQPFALNYARPAsph-sssPYsYDSGLQLNVLhDGRlAAsD+ALLRElGTTTSTAGSKTHFDD	0	1	3	3
+14251	PF14406	Bacteroid_pep		Ribosomally synthesized peptide in Bacteroidetes	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to\	a papain-like domain. It is often present in multiple tandem  gene copies. The gene contexts suggest that it is modified by the  ATP-grasp as in the biosynthesis of microviridin and marinostatin.  They might function in defense or development or as peptide antibiotics [1].	25.00	25.00	34.10	39.50	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.51	0.72	-3.81	17	17	2011-07-26 16:09:42	2011-07-26 17:09:42	1	1	5	0	0	17	0	50.80	32	80.28	CHANGED	MKKLsthp.S..hhpNpKLsstptpultGG.hpsthpphs.....hsssc.s+DsDsh	MKKLsthp.S..hhpNpKLsstptpultGG.hpsthpphs.....hsssc.s+DsDhh..	0	0	0	0
+14252	PF14407	Frankia_peptide		Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide linked to cyclases in chloroflexi.  It may have a link to cyclic nucleotide signaling [1].	48.00	48.00	48.70	48.50	41.00	36.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.77	0.72	-4.21	10	16	2011-07-26 16:57:07	2011-07-26 17:57:07	1	1	13	0	10	14	0	60.90	37	80.85	CHANGED	plE+lIGRAVoDssFRppLlsDucp......Ascs..YDLTsEELcAL-clcsssLpuhAtsLDtcLs+	.thEclIGRAVsDssFRppLlssscp......Ascp..YcLTsEELcAL-phcssshpshAtplD.plp+.........	0	6	10	10
+14253	PF14408	Actino_peptide		Ribosomally synthesized peptide in actinomycetes	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp and an aspartyl-O-methylase. Gene contexts suggest that it is further modified by the ATP-grasp  and the methylase. It might function in defense or development, or  as a peptide antibiotic [1].	25.00	25.00	28.00	30.10	24.80	18.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-9.06	0.72	-4.04	16	32	2011-07-26 17:11:13	2011-07-26 18:11:13	1	1	26	0	15	34	0	61.30	36	65.68	CHANGED	sPhssss.........lDPsTQhulhsDphG.pllE.hGKH.GTussstTsosTss..DGps...ptss-sDospD	.................Phssss.....lDPsTQhuhhhDptG.pls-.hG+H.GTuosspTsTsTus..DGps...spssDp-sspD...........	0	2	12	13
+14254	PF14409	Herpeto_peptide		Ribosomally synthesized peptide in Herpetosiphon	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to a papain-like domain. It is often present in multiple tandem gene  copies. Gene contexts suggest that it is modified by the ATP=grasp. It might function in defense or development, or as a peptide antibiotic [1].	50.00	50.00	50.60	50.00	28.70	27.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.98	0.72	-4.21	6	8	2011-07-26 17:54:10	2011-07-26 18:54:10	1	1	1	0	8	8	0	57.80	39	73.45	CHANGED	MEFcsh...KTEElPlI.....FGLTYLEEEAAEIsDVVGCLMPIDG..YosTGCDDSDts.....IP	Mchcsh...+hp-h.lI.....FGLTYLEEEAAEIsDVVGChhslDG.uYosTuCDDuDt.......P..............	0	8	8	8
+14257	PF14410	GH-E		HNH/ENDO VII superfamily nuclease with conserved GHE residues	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	A predicted nuclease of the HNH/EndoVII superfamily of the treble  clef fold which is closely related to the NucA-like family. The  name is derived from the conserved G, H and E residues. It is found in several bacterial polymorphic toxin systems [1]. Some GH-E members preserve the conserved cysteines of the treble-clef  suggesting that they might represent potential evolutionary  intermediates from a classical HNH domain to the derived NucA-like  form [1].	25.00	25.00	25.60	25.60	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.33	0.72	-3.83	51	101	2012-10-05 18:28:12	2011-07-27 20:41:42	1	24	88	0	22	106	0	70.40	29	13.00	CHANGED	sssGphhs...ssstpsl...............sphDMGHp...uhcatchhtph.pht..hopcEhp-ahp.sPcNYRlEp...sosNRS+ttE	........................t..pG.hhs....tstp.l......................t.hDhGHp....uhcapchhtth.p..tt..hopcphh-ahp.sPcsaRlEp...sSsNRSHtsE..	0	8	12	17
+14258	PF14411	LHH		A nuclease of the HNH/ENDO VII superfamily with conserved LHH	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems [1] and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved  histidines of which, the first one is predicted to bind metal-ion  and other three ones are involved in activation of water molecule for hydrolysis.	23.30	23.30	23.30	29.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.01	0.72	-3.77	25	102	2012-10-05 18:28:12	2011-08-10 22:52:37	1	25	88	0	22	112	2	81.20	35	12.15	CHANGED	TNhchhp...pGpuPhs..psG..cslpLHHlsQppsGPlsElopspHc...tspphLHshtpsups.......cspasp.+psYWKtRupphht	..........TNl-hMp...pGpAPls..pDG..pslpLHHltQcpsGslsElopstH...p...........tt....pphLHthhpss.psh.......+spFsp.RppYWKhRApp..p...	0	3	9	12
+14259	PF14412	AHH		A nuclease family of the HNH/ENDO VII superfamily with conserved AHH	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	AHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, AHH. It is found in bacterial polymorphic toxin systems [1] and functions as a toxin module. Like WHH and LHH, the AHH nuclease contains 4  conserved histidines of which, the first one is predicted to bind  a metal-ion and the other three ones are involved in activation of a water molecule for hydrolysis.	18.20	18.20	18.30	18.20	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.76	0.72	-4.07	49	340	2012-10-05 18:28:12	2011-08-11 01:08:44	1	41	221	0	113	345	45	106.40	19	19.54	CHANGED	spth..pttshtts...tshpuHHIlspps..........hhsttcplhcchGlc...........lssstNhlhlst........................hHp..GsHspp.....YpptVtcclppspp...............sppthhcpl.ppltccltsst	.......................tt...................shpsHHllspp................hh.th.p..pllpchG.hc...........lssspNtlhLP...........................................hHp....GtH..spt.........Ypphl.tppLpphpp..................ttsppthh...ptl.ppltpph............................................................	0	29	46	89
+14260	PF14413	Thg1C		Thg1 C terminal domain	Anantharaman V	la_psag	Manual	Domain	Thg1 polymerases contain an additional region of conservation  C-terminal to the core palm domain that comprise of 5 helices and two strands [1]. This region has several well-conserved charged residues  including a basic residue found towards the end of the first helix  of this unit might contribute to the Thg1-specific active site [1]. This C-terminal module of Thg1 is predicted to form a helical bundle  that functions equivalently to the fingers of the other nucleic acid  polymerases, probably in interacting with the template HtRNA [1].	26.30	26.30	26.70	26.60	26.00	26.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.85	0.71	-4.42	152	419	2011-08-11 14:39:21	2011-08-11 15:39:21	1	10	336	8	274	424	17	123.10	34	44.55	CHANGED	stpplpDYhsWRQ.sDsHlNNLYNssFWsLl.csGhospcApppLpGohuu-KpElLFpchGINYNs.P.tha++Gohlh+.................................................................................tt..pt.ttt+p+....pthhshat...........Dhh...ppFhcph..h..	........................................ppl+DYhuWRQ.sDs.............HINN.....LYNTsFWtLl...puGhospcApppLpGThuu-KN....ElLFpcaGI.NYN.s..Ptha+KGoslh+........................................................................................................p.......p..pt......pp.tht+p+....tt.hsha..........chht..ptFWpp.....p................................................................................................................	0	90	164	224
+14261	PF14414	WHH		A nuclease of the HNH/ENDO VII superfamily with conserved WHH	Zhang D, Iyer LM, Aravind L;	la_psag	Manual	Family	WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems [1] and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion  and other three ones are involved in activation of water molecule for hydrolysis [1].	25.10	25.10	25.20	25.20	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.40	0.72	-4.74	35	277	2012-10-05 18:28:12	2011-08-11 20:50:36	1	34	251	0	50	331	2	44.80	34	6.85	CHANGED	tttppspuaTWHHppcs......ssMQLVspslHst......htHsGGhuhhpst	.....s..htpspGaTWHHh.s-s........ssMpLVspphHps............htHs...GGhuthpt.t...	0	11	27	38
+14262	PF14415	DUF4424		Domain of unknown function (DUF4424)	Bateman A	agb	Jackhmmer:Q7P768	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 310 and 361 amino acids in length.	27.00	27.00	29.60	27.00	23.90	25.40	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-12.02	0.70	-4.88	97	165	2011-08-18 09:52:12	2011-08-18 10:52:12	1	4	135	0	43	147	14	218.20	25	71.31	CHANGED	pclpVcYhFpNsosp-lph.luFPh......P.............................h.hs.....s........sspshlpsF+lhVsG+.lpsph...........p.hs.................t.-lostLtppG..........h...t..h..........t...............tthh-tst..t.tashphhY.hWppsFsAGcsV.lcHsYpPs......lusul.......................t...tthChp.t.htthtth.............t..ht.pplsYVLoTuusWp.tsIt-FpLplc+sssspllshCa...ssl+Klssp........................................papappcNFsPpcD	..................clpVcYhFpN.osp-lp..luFPh......P.............................h..s..............sptshlpsFchhlsG+.ltsphp.hs....................................-lostlhttG.........................h...t.............t............thhctst....thshp.ha.hWppsF.supsl.lcHsYpPs......sutul.........................t...t..C.t.t..t.h.th................hh.pplsYlLsTussWt.tsItcFpLplctts.pt..llshCh...tsl++lssp.....................................phphppcsFhPpcD........................................................	0	15	27	31
+14263	PF14416	PMR5N		PMR5 N terminal Domain	Anantharaman V	la_psag	Manual	Domain	The plant family with PMR5, ESK1, TBL3 etc have a N-terminal   C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain [1].	29.20	29.20	29.20	30.30	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.22	0.72	-3.92	63	964	2011-08-19 17:52:04	2011-08-19 18:52:04	1	11	31	0	619	937	0	55.20	41	12.91	CHANGED	sppCDlhpGcWVhDsst..P......LYpspsCs..alppthsCtcsGRPDpsYhp.WRWpPcsCs	...............s.tpCDla..p.GcWVh....Dss......t.....P........LYs.s.p.sCs..alppphsChpsGRPD.p.s.Yh+.WRWpPpsCs.......	0	64	359	499
+14264	PF14417	MEDS		MEDS: MEthanogen/methylotroph, DcmR Sensory domain	Anantharaman V	la_psag	Manual	Domain	MEDS is prototyped by DcmR and is likely to function with the PocR domain in certain organisms in sensing hydrocarbon derivatives [1][2] The MEDS domain occurs fused to Histidine Kinase and as standalone version [2]. Sequence analysis shows that it is a catalytically  inactive version of the P-loop NTPase domain of the RecA superfamily [3].	28.70	28.70	29.50	28.70	28.00	27.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.09	0.71	-5.24	30	260	2012-10-05 12:31:09	2011-08-24 23:25:56	1	51	146	0	138	283	15	172.90	20	39.54	CHANGED	hctthRpSGl-llG.-lPaGTHhCQFYpTcE-Lh-lllPYhKuGLEsNEhChWlsop..P.plE-AKpuL+cslP-l...-hYL-+GQl-Ilsh..hh...hp-ushDspRllsshlcK.hscAlt.....pGYcGLRlsGsshWhtKp..-asshssYEpclDuslssp...phhuLCsYsl-chsus-llDllssHpFsLlK+ct+Wpp	.......................................................h......................sH.shhYp.sp.p-hhshhssFlppGLts.sE.....shhhss...stpht.lp.ptL....................hh.ssup.l.plh...s...h...............spushss..schlsthtph...hspuht......tGhpslRlhG-.hs.Ws..tcs....sphs.thh.paE.shlNphh.sst...shh.hL.CsYDt.......pphssp...s....lt-shtsHshhh.........t........................	0	61	101	117
+14265	PF14418	OHA		OST-HTH Associated domain	Anantharaman V	la_psag	Manual	Domain	OHA occurs with OST-HTH [1]. 	25.00	25.00	25.40	26.60	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.28	0.72	-4.48	28	75	2011-08-27 06:30:04	2011-08-27 07:30:04	1	8	27	0	69	81	0	74.20	23	9.32	CHANGED	...tps.hhFs..GGRYuhActL+cps..th+shoLGpls+lVQlAlp.ppllh.Ypps.sLhP...hpssppsssshhstssppp	..............s.......hs..sGRYshAcpL+cps..hh+shsLGclhclVpluls.c+hhh.Ypss.tlhP...hptstthspshhs.....s................	0	29	45	59
+14266	PF14419	SPOUT_MTase_2	SPOUT_MTase_11;	AF2226-like SPOUT RNA Methylase fused to THUMP	Anantharaman V	la_psag	Manual	Family	SPOUT superfamily RNA methylase fused to RNA binding THUMP domain [1].	28.40	28.40	28.60	28.40	27.80	27.60	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.93	0.71	-5.08	28	37	2012-10-01 22:53:19	2011-09-01 23:30:29	1	1	37	0	31	42	0	175.20	55	49.03	CHANGED	KlslVQMPYhGDhcus+phGE+IGRAAQuFEVKELIIAP+cplsAaELhpFl+GV+cGQcSRYpIQ++uYshcVc+VPVhVhDLYQllRDK+R.pscllIlTDPKGcplocVK-+Lucsh.....+tu+EVllFlGSREGIPpGlFRFADaVlDLAPahTFATEauIPusLlALholYEEtt	........................KlslVQMPYhGDhcusRphGE+IGRAAQuFEVKELIIAP+cphsAaELhpFl+GV+cGQESRYpIQ+cuYshcVcKVPVhVaDLYQllRDK+R.ppcllIlTDPKGcplscVK-+LAcsh.....+hu+EVllhlGS.REGIPp.....Gl..FRFADaVlDLAPa...hTFATEauIPusLlALholYEEth.....................	0	11	15	21
+14267	PF14420	Clr5		Clr5 domain	Bateman A, Wood V	agb	Wood V	Domain	This domain is found at the N-terminus of the Clr5 protein which has been shown to be involved in silencing in fission yeast. This domain has been found to often be associated with proteins that contain ankyrin repeats and large regions of disordered sequence [1].	22.30	22.30	22.30	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.67	0.72	-4.07	93	327	2011-09-06 09:24:57	2011-09-06 10:24:57	1	30	74	0	281	320	0	54.30	29	10.23	CHANGED	tspcW-th+shIpcLYh......pcphsLc-VhchM.....cpcasFpA....o...................c+tYcp+hc.cW..GhpK	............spsW.-sh+shItcLYh......pcphsL...c-VhchM.....cppasFps....o...................................................................p+tappphc.cW..shtK................................................................	0	54	142	232
+14268	PF14421	LmjF365940-deam	CDD_CDA_1;	A distinct subfamily of CDD/CDA-like deaminases	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A distinct branch of the CDD/CDA-like deaminases prototyped by  Leishmania LmjF36.5940. Members of this family are widely distributed across several microbial eukaryotes such as kinetoplastids,  chlorophyte algae, stramenopiles and the alveolate Perkinsus. Domain  architectures suggest that these proteins might possess mRNA editing  or DNA mutagenizing activity [1].	45.70	45.70	134.30	59.00	32.40	23.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.63	0.71	-4.92	12	36	2012-10-02 00:10:39	2011-09-07 19:24:38	1	2	20	0	17	35	0	133.90	25	37.19	CHANGED	shhslhh-p.psahsphsshh.p....ppscs.Wh+Ks.p+PVlssLh..Vchc....sthst.sup.p................................hhhulNhElShPoGShCSEpNAlGp...............lAslul.........................................................................................................PTps....................................hRt.................................h.s............tst+ps.........................NPLaPCGsCpphL+Klsc.....hssshplhhF-ss.pscplhhhsls	...s.....hhp..t.....h............t..ah+ps..+.Vls.lh..h..................................................h..uhNhElShPoGShCuEpsshup.hs.........................................................................................................................................................................................................................................................................t...........................pP.h.shs.s.phL.+ltp......ss.hhlhhats..p..t.lh............	0	10	14	17
+14270	PF14423	Imm5		Immunity protein Imm5	Iyer LM, Zhang D, Aravind L.	la_psag	Manual	Family	A predicted Immunity protein, with an all-alpha fold, present in bacterial polymorphic toxin systems as an immediate neighbor of  the toxin [1] .	25.00	25.00	35.50	35.50	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.17	0.71	-4.67	12	38	2011-09-07 22:45:15	2011-09-07 23:45:15	1	3	23	0	12	41	0	171.10	29	58.91	CHANGED	ppIEK....Lpc.IspsuhGHLsLshRlcLM+pIsssph...........lpKlhhpCspKssuhascpFss-s.l.plLtchp..paLYpscGsh-pl.s.s-RhcsYlpps.-ps.-hssaslluL..GaAltsDAuolls.tDYsu.ED....DssaD.EuWssDFlsulAhSGu..PFs..-sGssE+R+cYWhWYlphslphsp	.......................................................lp+....hht.lttss.GcLsLshRhplhpthspsp...............lptlthhCsc+shshWscpFsssp.l.thLp...phL.pscus.......hcphts.ht+.p.asp.h.ppshshsthshhhl..uaAAssshs..osl.p..p...a..ss..cD.....Ds-hDPEua-ssalsu.AhuGGhsa....s-psssEtRRtaWhWYLs.sls...h....	1	3	10	11
+14271	PF14424	Toxin-deaminase	DEAM-TOXIN1;	The  BURPS668_1122 family of deaminases	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Burkholderia BURPS668_1122 [1]. Members of this family are found as toxins in polymorphic toxin systems in a wide range of bacteria and in the eukaryote Perkinsus. Members of this family typically possess a DxE catalytic motif in Helix-2 of the core fold instead of the more common C[H]xE motif.  The Perkinsus versions are predicted to be inactive [1].	29.60	29.60	31.20	31.20	27.30	28.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-11.09	0.71	-4.18	14	120	2012-10-02 00:10:39	2011-09-08 05:48:19	1	24	101	0	32	108	0	131.10	30	15.23	CHANGED	ptphscl+tshs............hchtNhulAchchph......stphhuhSt.spstt......t.............h..ps.....ssplhps....................tsssphh.....sRhsDoEhKlLcpltppltssshss.................GplslFoppssCpSCts.llppFptcaPpIphssh....s	.............................................................t....tph+.phst........thpp.uNhAlAch.pltuh......pphh.A.Sthsphpt......t.........................hs.ps.........ps.hFcs..t..................tpssh.h..................Rsh..DoEhKlLpsIAppLss..sppss..................Gp..IcLaTEhssCsSCs.........s.VItpFpp+Y.PNIplplh...t.................	0	5	25	26
+14272	PF14425	Imm3		Immunity protein Imm3	Iyer LM, Zhang D, Aravind L	la_psag	Manual 	Family	A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene [1] .	25.00	25.00	25.40	26.40	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.48	0.71	-4.13	26	52	2011-09-08 18:59:05	2011-09-08 19:59:05	1	2	39	0	8	34	0	116.30	55	95.29	CHANGED	McDWEYNELF-AIpEsYcEhL---R.Ga+YAIA+luDE.F...D...NL...GKIEDVIVDTAIGEIslsHc.+VFlGhIcGITKRLShFN.pEAp.....sELThEEI+DLopRINpVlEGLcNVclDYpPSs	..................MKDWEYNELF-AIpEsYcElL-E-R..GY+YAIAKLuDE.F..D...NL...GKI..EDVIVDTAIGEIulsHc.KVFlGhI-GIT+RLSpFNsQEAt.....sELTlEEIKDLSpRINKVIEGLKNVclDYsPSs..............	0	4	6	6
+14273	PF14426	Imm2		Immunity protein Imm2	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene [1].	35.70	35.70	39.80	39.60	35.20	34.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.72	0.72	-3.97	5	9	2011-09-08 21:17:19	2011-09-08 22:17:19	1	1	9	0	1	7	0	59.30	46	73.66	CHANGED	MLEVlsLILSAGRuPD+V-haHpctI+cLLpEIsLssLLcDlPuDEAuELRcDLRlLKLl	MhsVIhhILSGGhaPDh.-.hh+ctIhchlhsIsLssLLpslPuEEAE.hRaDLRlLKhl.	0	0	0	1
+14274	PF14427	Pput2613-deam	Pput2613-DEAM;	Pput_2613-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Pseudomonas Pput_2613 [1]. Members of this family are predicted to function as toxins in bacterial polymorphic toxin  systems  [1].	25.00	25.00	28.40	54.70	22.70	17.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.47	0.71	-4.42	4	6	2012-10-02 00:10:39	2011-09-08 22:47:24	1	5	5	0	2	7	1	116.50	34	4.32	CHANGED	pF.uSu+Gs.HpAhsslpDssGplpspuhhh.SGNMTpsEttLGFPcsSLATHTEuRhs+pls.pp....GDhhlI-GpYsPCspCKGtMphtupcoGAclpYpWspsst..schWpsGph+cp+	....F.uSu+Gs.HsAshslaDssGslpspuslh..SGsMTcsE+pLGFPcsoLATHTEuRhl+cls.ss....GDhhlI-GpYPPCs....uC+GtMpttupcoGupIpYpW.psts..scpWpttp.pp.p........	0	1	1	1
+14275	PF14428	SCP1201-deam	SCP1201-DEAM;	SCP1.201-like deaminase	Iyer LM, Zhang D, Aravind, L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Streptomyces SCP1.201 [1]. Members of this family are predicted to function as toxins in bacterial polymorphic toxin  systems [1].	25.00	25.00	36.00	35.40	22.00	21.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.00	0.71	-4.46	25	44	2012-10-02 00:10:39	2011-09-08 23:43:07	1	10	31	0	24	53	0	131.40	25	15.12	CHANGED	spphsPshsssthtth..............sthTpGplFctsGp....lsshh..Su..ccp.tpthhshhtspu.........s.hshssHVEsKhAhhMpc.......suhccuslsIN..ssPCst............CcphlPtlLPcGSoLpVahst......sstlcGtu.t	...............................sP.hhsshh.th..h..........ts.hTpGplaptss.t...hsshh...Su....pcp.hptlhphhtshs.........s.hshssHVEsKhAhhMpc.........suhcpuslhIN..ssPCss.........t....CcphlshlLscGupLpVhhst......thhhtuh..h................	0	11	21	23
+14276	PF14429	DOCK-C2		C2 domain in Dock180 and Zizimin proteins	Zhang D, Aravind L	la_psag	Mannual	Family	The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated  cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the  Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain [1][2].	25.30	25.30	25.70	27.50	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.24	0.71	-4.65	45	1118	2012-10-10 12:23:49	2011-09-09 02:18:47	1	34	216	2	631	942	4	187.60	30	10.24	CHANGED	h.ssapNpLalthpphshs.....Kpsp.............t+Nlhlslplpsscsp.......pshpsIastsss.....phpsphtoslha+scpspat-plKlpLPhplspptHLhFohhcsssp......psppt....p.huaualPLhc..sGph.............lpssphsL.lh..............tp..ttYhphs.t....................hhcss+shhplpsplsSohhspsssl	............................sshRNcLYlh.pphcas............+ttp............................spsRNlpVplphhsu-sp......................phhpsI..astuus.............htsph.ho.s.....V.haHs.p.s...........Pc.ah-plK..lpl....P.....hph........hpp.......p.HLhFoFhHhSsp.......................pppcpt............Ep.hGau..alPLhp...c.Gp................................lpsup..apLsV................ttp.sssY.L.sl.ssst.tht........................................................................shphscu.sKssFplpohlsSThhTQsspl....................................................................	0	183	251	418
+14277	PF14430	Imm1		Immunity protein Imm1	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A predicted immunity protein, with an alpha+beta fold and a conserved C-terminal tryptophan residue. The protein is present in a wide range of bacteria in polymorphic toxin systems as an immediate gene  neighbor of the toxin gene [1].	25.70	25.70	25.80	26.20	25.00	25.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.51	0.71	-3.98	26	58	2011-09-09 15:11:35	2011-09-09 16:11:35	1	1	41	0	26	66	2	125.30	16	90.44	CHANGED	lpshhstt.......pssshhlso.s-l....-tllcchsthshs.....hsplhhs.s-...st....hshlssGl...s.sshuh.hhhhs....ss.s..sthhstssss.......tt..hhashssssp-..a..Ps....sppls....l-ssppAstpFhpsG.p+PsslsWppt	.........................................................h................tt.h.hts.tpl....pthlpth.tt.t.............hhplhhs.ss....s.........shlssul...p..sphuh..lhhhs.........ss.s....tthhssssss.....stt......hp...hsssss-.....a..Ps....sstlsl-psppAlp-Fhp..ou..p+PsslpWp..h...	0	7	19	25
+14279	PF14431	YwqJ-deaminase		YwqJ-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Bacillus YwqJ [1]. Members of this family are present in a wide phyletic range of bacteria and a few basidiomycetes. Bacterial versions are predicted to function as toxins in bacterial  polymorphic toxin systems [1].	25.90	25.90	25.90	28.00	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.86	0.71	-4.27	14	91	2012-10-02 00:10:39	2011-09-09 18:36:12	1	16	76	0	42	98	2	125.80	27	22.31	CHANGED	hshhtspshstpchs.sshuuslchp......sGchhpuhstttp.............sslHPhlpshlsph...............pthpp.a..........tsGppAEltulsptLhp..........................tstchhshthpth.....hshtpGthh.sCssCshllpphsh	...................................ttp...........th..sssAuulshc..Gp.....hhputuspss............sssLHPhlpchLDshss.........................sppcp.a...............sGpCAEshhluctLtsh-tt...............t.tttshp.tu+lpstplRps.....scshcG.....s..htsPCcsCsslhsphs.........	0	8	31	38
+14280	PF14432	DYW_deaminase	DYW_Deaminase;	DYW family of nucleic acid deaminases	Iyer LM, Zhang D, Aravind, L	la_psag	Manual	Family	A family of nucleic acid  deaminases prototyped by the plant PPR DYW proteins that are implicated in chloroplast and mitochondrial RNA transcript maturation by numerous C to U editing events [1]. The  name derives from the DYW motif present at the C-terminus of the  classical plant PPR DYW deaminases. Members of this family are  present in bacteria, plants, Naegleria, and fungi [2]. Plants and  Naegleria show lineage-specific expansions of this family. The  classical DYW family contain an additional C-terminal metal-binding  cluster composed of 2 histidines and a CxC motif and are often fused to PPR repeats. Ascomycete versions, which are independent lateral  transfers, contain a large insert within the domain and are often fused to ankyrin repeats. Bacterial versions are predicted to  function as toxins in polymorphic toxin systems [2].	25.60	25.60	25.70	25.60	25.50	25.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.90	0.71	-4.10	17	1779	2012-10-02 00:10:39	2011-09-09 19:11:19	1	778	129	0	1096	1827	0	121.80	40	20.51	CHANGED	sssshsps.....hphhuG.ts+...........phhpRh.ps.shh.spsp.hhH.slcspcpp...................hhhpHuEK.tlshuhhp.................hhhps.....................................................................................................................................+lCsDCashhphluphhsp-IhVpDs.sph+hFc	.................................................................................................................ht.hh.............HtFhssDp.sHPptppIh.......t.Lpclht.c.h..c.p.t..G..Y..h...P-op.h.V.La..Dl.-.-....E.pK..................................h.L.t...hHSEKLAlAFG...Llsossu.....................sslRlhKNL....................................................................................................................................RlCsDCHsuhKhIS+lh.sREIllRDs.sRFHHFc.........................................	0	111	754	916
+14281	PF14433	SUKH-3		SUKH-3 immunity protein	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems [1].	24.60	24.60	24.60	25.50	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.46	0.71	-4.41	35	175	2012-10-01 20:46:44	2011-09-09 19:50:34	1	3	133	0	43	157	2	134.00	22	81.79	CHANGED	spplhphLppuGWh.......tsRplshshhhpthtpt.....ua.lhssstp..FLpcFGsLplt.......................tppssstshphsPhhsh.....tpppphpphtph.....lssplhPlGpht...ssthhLhls....-sGplashtp...........thhhlGsshppulpsllpupt.t	................................................tl.thLptuGWh.......psc..p..h..s...hsh......hhcthtpt..........tatl..hs..ushc..hhpcaGuLpht..t....................tpphsstshthcPhpsh.............h.tpphtphtpt.....ls.pplhPlGptt.....psphhlhls....ppGclYuh.cs.............h.hhhGsshppulppLltut..t.......................	0	11	30	39
+14282	PF14434	Imm6		Immunity protein Imm6	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A predicted immunity protein, with an alpha+beta fold (mostly alpha  helices). The protein is present in polymorphic toxin systems as an  immediate gene neighbor of the toxin gene [1].	25.00	25.00	30.70	30.60	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.36	0.71	-4.41	29	64	2011-09-09 19:11:10	2011-09-09 20:11:10	1	1	38	0	18	54	0	119.00	28	74.73	CHANGED	hspstahLsluptlhshl.cppp.p...........ph..ccuL-tCW...pal-s.cphsuDpLYshL-s.pD.pslhhahp..pc.ccpp.shWssIhsAluhsuhhA.YphEscca.lPpslEslD.-ppl-hahpphpchh	.................h..hstahLtlu-tlhshlppppht...........phh.ccuL-tCa...pal-s.cphsuDpLYshL-s.tD...pslhhahp..p-.ccpt.shWssIhpuluhsuh.A.Yph-sc+a.lPpslEslD.pphlchahpshpch..................	0	5	7	10
+14283	PF14435	SUKH-4		SUKH-4 immunity protein	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems [1].	25.50	25.50	25.50	25.50	25.20	24.40	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.03	0.71	-4.56	32	180	2012-10-01 20:46:44	2011-09-09 20:14:07	1	4	115	0	50	183	1	163.60	18	61.38	CHANGED	stppltphasttt...............lhphpptsh.....sthhp.pspcFLppsGlPpss......hhhhtss................hstlsph.h..........................stthtpahhlGpss....ts.lslct.soGpVhhlssss.......phhhlNoslspFspslhhhtphhtthtt.tt...................................tpp.pshstphppplptlDstAht.........stsaWstlhppl	.......................................................................t.........s.t................lhph.ttth.....t..h...stphL....sGlP.p.......hh.hts.................h..htph...........................stphtpahhlGpsh.........ss.lslp....ssuplhh.ls.ps..............p.hhlNoslspFspslhhhtchhpthhths.....................................tpt.tphhtp..hp...p.....plttlDsssht..........tsaWs.hhpp.............................................	0	11	35	48
+14284	PF14436	EndoU_bacteria		Bacterial EndoU nuclease	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	This is a bacterial verion of EndoU nuclease. It is found at C-terminal region of polymorphic toxin proteins. 	25.50	25.50	25.70	25.70	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.70	0.71	-4.30	57	308	2011-09-09 20:44:37	2011-09-09 21:44:37	1	33	244	0	65	277	3	120.20	21	21.59	CHANGED	sspshpHlhpG-hspt........thsGhHttsth..................sp.l.p.ht.........ss.pGlhpsphph.t.stt.............tstoohFPpp..WospclhstlppAhpspptpt.................ssphtutsss..............Glplc.shhpsp....GplhosaPhh	..................................................................s.....tHh.tsp..t..........h.GhHt.s.....................ht.lhttht..........pGlhphphph.t.stt...................tstpohFPcs..WocpcIhptlppAhpstthht.................sphhtstsps..............Gl+lc.shhcst....GplhohaP.....................	0	13	31	47
+14285	PF14437	MafB19-deam		MafB19-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Neisseria MafB19 [1]. Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems [1].	28.90	28.90	29.00	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.99	0.71	-4.56	20	53	2012-10-02 00:10:39	2011-09-09 23:23:34	1	17	53	0	8	55	3	145.10	37	12.83	CHANGED	hsshsphtshp.tlG.shstt...............tsshsslApscIsGppFhssNpsu+s...lus....spsshhssplthp.t.........spsshsssHAElsslQQAa-t..Ghsh.GpshshhVs.+-lCshCp....uslsshAcchGLcpLslaspt..oG..pshhasss	...........................................h...................................psp.pVlAcusIsG..cpFhDsNQoA+....lus..sspPTLhutplphchp.....t..tPN.sshusuHAEIulIQQAYsA..GhTt.GtsMshhVsGK-VCuaCp....GslsuhAcpoGLcpLslpsss..oG..pohYap..................	0	3	3	4
+14286	PF14438	SM-ATX		Ataxin 2 SM domain	Anantharaman V, Eberhardt R	la_psag	Manual	Domain	This SM domain is found in Ataxin-2 [1].	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.49	0.72	-4.05	52	367	2012-10-01 22:42:21	2011-09-11 08:17:31	1	11	227	28	216	462	1	75.30	29	8.85	CHANGED	cRhhahhssllGppVpVplpsGsh.YcGlhpohssp...........phsllL.chs+hlsss.t..........ppstspphhcslllpspDllp	...........RhlahlssllGppscVp.l+.sGsh.YcGlF+ohos............chslsL.chs+chsspss.............ssspppsls-ohlhpssDls......................................	0	66	108	163
+14287	PF14439	Bd3614-deam		Bd3614-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Bdellovibrio Bd3614 [1]. They are typified by a  distinct N-terminal globular domain. The Bdellovibrio version occurs in a predicted operon with a 23S rRNA G2445-modifying  methylase suggesting that it might be involved in RNA editing [1].	38.50	38.50	39.20	130.90	37.70	37.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.65	0.71	-4.31	4	4	2012-10-02 00:10:39	2011-09-11 22:36:34	1	1	4	0	4	4	0	124.00	36	37.69	CHANGED	pshacRDRcVsAhLlssp.GtlhssAsNoNucNtsLHAEhNLLhPhhhtp.......................t+sl.sGspLhVTLQCC+MCAAhlsthu-t.ut...hcVsYhpEDsGuLARcTtLcp+GhEp+hst	.pshacRDRcVsAhLlssp.GtlhssAsNoNucNtsLHAEhNLLhPhhhtp.......................t+sl.sGspLhVTLQCC+MCAAhlsthu-t.ut...hcVsYhpEDsGuLARcTtLcp+GhEp+hs..	0	2	3	4
+14288	PF14440	XOO_2897-deam		Xanthomonas XOO_2897-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Xanthomonas XOO_2897 [1]. Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems [1]. The Xanthomonas XOO_2897 lack an immunity protein and is predicted  to be deployed against its eukaryotic host [1].	32.60	32.60	33.40	36.00	31.40	31.40	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.97	0.71	-4.39	16	52	2012-10-02 00:10:39	2011-09-11 23:02:42	1	9	41	0	20	57	0	113.50	36	17.59	CHANGED	h.s.sshshsG.......sptsshhtpss................pphlhtp........................................tssHuEcpllpplpp....tsltPsplhclYoEhpPCst.t....Ctphlcs.h.ssscloaohs..aGt-ttst...hppuhspLhp	...................................................................s......s.hG.......s..sshhhps...............t.tp.hhtpu.t...................................ssssHsEhphhppLcs.......hsVsPppVlELaTELEsCchPGsh....Cuchl+cpa.PpsRlopsss..YGsDpsu...RppGhppLl.t..........	0	5	14	19
+14289	PF14441	OTT_1508_deam		OTT_1508-like deaminase	Iyer LM, Zhang D, Aravind L, Eberhardt R	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Orientia OTT_1508 [1]. Members of this family are present in a wide phyletic range of bacteria,including several intracellular parasites and eukaryotes such as fungi, Leishmania,  Selaginella, and some apicomplexa. In bacteria, these deaminases are predicted to function as toxins in bacterial polymorphic toxin  systems [1]. Versions in intracellular bacteria lack immunity proteins and are likely to be deployed against their eukaryotic hosts. Eukaryotic versions are predicted to function as nucleic acid (either DNA or RNA) deaminases. Among eukaryotes, some fungi show  lineage-specific expansions of this family. Many fungal versions are  fused to a distinct N-terminal globular domain. Various fungal  versions are fused to domains involved in chromatin function.  Apicomplexan versions are fused to tRNA guanine transglycosylase  domain [1]. 	25.00	25.00	25.10	25.40	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.54	0.71	-4.39	23	207	2012-10-02 00:10:39	2011-09-11 23:54:14	1	6	86	0	171	219	0	165.50	15	29.16	CHANGED	htttthphtshph.sht.....................phts.thhtthptpt...tt.......................pshhhthppp..............................................t.psplHAEhhllcplppp...................st..YlG....sSKhsCssCphhlpths.............ttpsshhts....cspsa.tW.phss...............tpspthpphh	..........................................................................................................................hh.t..................................................................................................h........t.......................................................phpstlHAElpllpahtppt.............................hhss.pYIG.sSK.uChhCphahpths...............phhhhts.....HsplY..pW.phPs......................ht.h..........................................	0	35	93	140
+14290	PF14442	Bd3614_N	Bd3614-N;	Bd3614-like deaminase N-terminal	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	This is a globular domain that occurs N-terminal to the Bd3614-like deaminases, which are predicted to be involved in RNA editing [1].	25.00	25.00	65.00	63.60	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.75	0.71	-4.20	4	5	2011-09-12 09:35:36	2011-09-12 10:35:36	1	2	5	0	5	5	0	126.80	35	37.92	CHANGED	puSscccDVAFLlAsssu-...u-AcssVaaApussssss.cSAlV+LlLG..........AppuusRspusuW..hRtRIhTT.tulSshDRAhVKVsApRsTth......slcscDcuAsA......st.sssDDscs........LphhDsTshAptAlpRGh.s	...puSscccDVAFLlAsssu-...u-AcssVaaApussssss.cSAlV+LlLG..........ApEuuGRspucuW..hRpRIaTT.+ALSshDRAlVKVsApRATsl......clcsDDDuAsA......st.sssDDDDDDDAs......LEhcDlT-aARtAlcRGAp.s	0	3	4	5
+14291	PF14443	DBC1		DBC1	Anantharaman V	la_psag	Manual	Domain	DBC1 and it homologs from diverse eukaryotes are a catalytically  inactive version of the Nudix hydrolase (MutT) domain [1]. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction [1].	25.00	25.00	26.30	26.40	22.70	21.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.61	0.71	-4.62	13	186	2012-10-02 00:00:35	2011-09-12 21:55:47	1	8	89	0	108	182	0	122.50	51	12.57	CHANGED	.sHPs+llKFLVGp+sK.EsMAIGGpWSPSLDGsDPpsDPpVLI+TAIRssKAhTGIDLSsCTpWYRFsEl+YhRstppt.....sss+lETVVlFLPDVWshlPTcp-WcsLptshpppLscphptspppss	............pHPs+hlKFLV.G..hKu+..E..........sMAIGGpWSPSLDG..sDPppD.PsVLI+TAIRssKALTGIDL..SsCT.............pWa...RFAEl..........+YhR.stppt.............................sPs+lETVVlFhP..DlWphhPohpEW-slppthppphs.cphpt.....s.....................	0	32	49	73
+14292	PF14444	S1-like		S1-like	Anantharaman V	la_psag	Manual	Domain	S1-like RNA binding domain found in DBC1 [1]	25.20	25.20	25.70	25.30	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.61	0.72	-4.24	11	185	2012-10-03 20:18:03	2011-09-12 22:52:37	1	6	68	0	90	173	0	56.30	57	7.05	CHANGED	QRVF..TGh..VTKlp-sFGFlD--VFFQhSs.VKGthPpVGDRVLV-AuYNssMPFKWNAsR	......QRVF..TGlVT+L..H.DsFGhVDE-VFFQl.........Ss.VK...G+.hP.p.VG-+VLVcAsYNPs...sh.WNA.+..............	0	18	26	48
+14293	PF14445	Prok-RING_2		Prokaryotic RING finger family 2	Burroughs AM, Iyer LM, Aravind L	la_psag	Manual	Family	RING finger family found sporadically in bacteria and archaea, and  associated with other components of the ubiquitin-based signaling  and degradation system, including ubiquitin and the E1 and E2  proteins. The bacterial versions contain transmembrane helices [1].	22.10	22.10	23.00	91.00	21.20	21.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.31	0.72	-4.02	2	3	2012-10-03 15:03:13	2011-09-16 18:03:25	1	1	3	0	2	3	0	57.00	53	61.96	CHANGED	DPcSFupasCDLCpoutslutLRQCVlCGRWuCsuCWpDEYYhC+SCuGlhplh.Lc	DPcSFSRYoCDLCNooaPlu-LRQCVLCGRWACuSCWpDEYYsCKSCuGIIsLHLLc..	0	1	2	2
+14294	PF14446	Prok-RING_1		Prokaryotic RING finger family 1	Burroughs AM, Iyer LM, Aravind L	la_psag	Manual	Family	RING finger family found sporadically in bacteria and archaea, and  associated in gene neighborhoods with other components of the  ubiquitin-based signaling and degradation system, including  ubiquitin, the E1 and E2 proteins and the JAB-like metallopeptidase.  The bacterial versions contain transmembrane helices [1].	29.10	29.10	29.10	29.30	29.00	28.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.56	0.72	-4.23	14	24	2012-10-03 15:03:13	2011-09-16 19:23:01	1	3	21	0	11	26	7	52.80	34	12.45	CHANGED	.phpsstCssCGcpht.p-DlVVCPcCGAPYHRpCapchGpChphs.pssshshp.	......phpsspCshCGcphh.p-DlVlCspCGAPYHRpCapchGpChh.s.pttshph.h......	0	7	8	11
+14295	PF14447	Prok-RING_4		Prokaryotic RING finger family 4	Burroughs AM, Iyer LM, Aravind L	la_psag	Manual	Family	RING finger family domain found sporadically in bacteria. The finger is fused to an N-terminal alpha-helical domain, ROT/Trove-like repeats and a C-terminal TerD domain [1]. The architecture suggests a possible role in an RNA-processing complex [1].	27.00	27.00	27.00	27.60	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.18	0.72	-4.42	10	46	2012-10-03 15:03:13	2011-09-16 19:42:08	1	2	46	0	15	52	1	54.70	37	7.14	CHANGED	hhhQpP-QPClhCutsuos+slsPCuHlVCcsCFDGscYSuCPlCts+l-sucPF	...................h.p..hshlhshhsspp.sshLsCGHl.I.PcsTFPh..-RYN...GCPFCGsPF-sus...........	0	10	12	14
+14296	PF14448	Nuc_N	NUC_N;	Nuclease N terminal	Zhang D, Iyer LM, Aravind L, Eberhardt R	la_psag	Zhang D, Iyer LM, Aravind L	Family	This is a conserved short region that is found in many bacterial polymorphic toxin proteins [1]. It is often located before C-terminal nuclease domains [1].	25.00	25.00	27.70	26.20	18.80	17.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.92	0.72	-4.42	2	47	2011-09-16 20:53:49	2011-09-16 21:53:49	1	7	29	0	1	42	0	54.40	79	19.80	CHANGED	hDpsoshh+G..ElL.DGSVhR.uGTNaStphpEAHDuSKASIQSRISNLESGGVKGTtc	....hDoVoshhKG.VEIhPDGSVsR.oGTNYSGKFQEAHDASKASIQSRISNLESGGVKGTG..............	0	0	0	1
+14297	PF14449	PT-TG		Pre-toxin TG	Zhang D, Iyer LM, Aravind L, Eberhardt R	la_psag	Zhang D, Iyer LM, Aravind L	Family	PT-TG is a conserved region found in many bacterial toxin proteins. It could function as a linker that links N-terminal secretion-related domain and C-terminal toxin domain. It contains a TG motif [1]. 	23.50	23.50	23.50	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.43	0.72	-4.20	37	309	2011-09-16 21:38:00	2011-09-16 22:38:00	1	46	140	0	52	270	1	81.40	27	17.49	CHANGED	pppthshhh-hss..lushp-shcshpGpD..hTG-cl.shh-Rshuul.hh.uh.hs..huKlsphstth.thh....+uhcsstcsp	..............t.hchsh-hss.ElsGhhDhtRshsGhD.PsTGE+L.osh-Rl.h.Aushslhuh.hP.....hG+suphsp.sshths........+shtts....t............................................................	0	11	25	33
+14298	PF14450	FtsA		Cell division protein FtsA	Bateman A, Mian N, Griffiths-Jones SR, Anantharaman V	la_psag	Pfam-B_1177 (release 5.4)	Domain	FtsA is essential for bacterial cell division, and co-localises to  the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains [1].  The FtsA protein contains two structurally related  actin-like ATPase domains which are also structurally related to the ATPase domains of HSP70 (see PF00012). FtsA has a SHS2 domain  PF02491 inserted in to the RnaseH fold PF02491 [2].	31.80	31.80	31.80	31.80	31.70	31.70	hmmbuild  -o /dev/null --hand HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.43	0.71	-4.27	219	7122	2012-10-02 23:34:14	2011-09-17 14:26:47	1	10	3572	5	1490	4911	2477	177.60	22	77.84	CHANGED	lshlDlGuupsshslhct.....sshtt..........hpllslG.............ustlo..cclupul......ppslppAEcl...chphu..................ss..hh.........sthp.tppphp.lsh................t.spplsppclscllpsthp..........Ellchlspph........hpssh.ht...p.hssshVlTGus.utlpsl.tchspchh...............lcls..t....................hltsP........aA.ouhul	....................................sslDIGsupssshlhct..........t.t.tt...................hsllshG................ssh....ls........ccl......u......pul.............pp.s.h......p......p.A......Eph...ch.p.h.u.......................ss..hsslsupp.phtsspshsshsppthpppthphh.....................................................thh.ch.phhcp.hshtshch.stuhllTGusuhlpsl.hcsspcsh........................l+ls..p.............................hl.hp.P...husuhu................................................................................................................................................................................................................................................................................................	0	491	953	1235
+14299	PF14451	Ub-Mut7C		Mut7-C ubiquitin	Iyer LM, Burroughs AM, Aravind L, Eberhardt R	la_psag	Manual	Family	This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role [2].	23.00	23.00	23.00	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.45	0.72	-4.46	22	253	2012-10-03 10:59:06	2011-09-19 19:24:29	1	2	245	0	99	309	28	79.60	36	34.19	CHANGED	MssssFRFatELNsFLs.spRp+thupssscsATlKHhIEALGVPHTEVthlhVNGcssshs+hlp-GDRlsVYPphcshc	..............................lphRhasELscFls..h.t.t.R..t......t.s.ht.p.....sht.sssTlKcllEuLG..V..PHTEVsllL....VN....Gcsss...a....s....a....h....ht....sGD+luVaPhhcs.....................	0	31	68	89
+14301	PF14452	Multi_ubiq	Bac_multiUb;	Multiubiquitin	Iyer LM, Burroughs AM, Aravind L, Eberhardt R	la_psag	Manual	Family	A ubiquitin superfamily domain that is often present in multiple  tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification  system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain [1]. The E2/UBC fold domain appears to be  inactive. The JAB domain in these operons is usually fused to  the E1 domain [1].	24.50	24.50	25.20	24.70	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.88	0.72	-4.00	24	160	2012-10-03 10:59:06	2011-09-19 22:07:54	1	7	84	0	69	158	3	72.20	21	64.51	CHANGED	pshphplsscphshscshloGpplhtlAthssss......phshhphh.ssppcslt.s-sV-LtppGhc+Flshpsc	.......hphtlsscphphscstloGpplhplAthssss......thsh.hphh....s.sptpplt.s-s.l-Lp....ppGhE+Flshp.............	0	22	43	59
+14302	PF14453	ThiS-like		ThiS-like ubiquitin 	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the ubiquitin superfamily that is often fused to the  ThiF-like (E1)- ubiquitin activating enzyme and is present in gene neighborhoods with components of the thiamine biosynthesis pathway [1].	26.00	26.00	28.30	27.10	25.60	24.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.46	0.72	-4.12	8	166	2012-10-03 10:59:06	2011-09-19 22:35:31	1	2	166	0	20	104	3	56.80	56	21.39	CHANGED	M+IhlNEcplsVc-ssoLatl+sphKs-ADVlIlNGFPlp-DhtLp-sDclhhI+RG	..................................MRlKFNGKELDTchpTSL-FFcslSKN..END..VW.IINGFATKENItLpENDELFCIE+N.	0	7	19	20
+14303	PF14454	Prok_Ub		Prokaryotic Ubiquitin	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A Ubiquitin-superfamily protein that is present across several  bacterial lineages, and found in gene neighborhoods with components of the ubiquitin modification system such as the E1, E2 and JAB  proteins, and a novel alpha-helical protein, which is predicted  to be enzymatic [1].	25.00	25.00	25.20	27.80	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.88	0.72	-4.32	7	94	2012-10-03 10:59:06	2011-09-20 00:17:57	1	1	75	0	32	85	3	66.90	41	79.77	CHANGED	lphppLpRsFpa....NGhsLsDPsPpho.cpV+DFYSspYPELhsAsl-GPpscsshtpYoF++usGs	....hplpsLpRsFpa.....ss..l.p..LsD.P.ss.shSs-pVh-aYosp.YPELTTAsVcGPpl..cs-ptlYpF+pslGs.....	0	7	22	29
+14304	PF14455	Metal_CEHH		Predicted metal binding domain	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A predicted metal-binding domain that is found in gene-neighborhood associations with genes encoding components of the bacterial homologs of the ubiquitin modification pathway including the E1, E2, JAB  metallopeptidase and ubiquitin proteins. The domain is characterised  by a conserved motif with a CxxxxxEYHxxxxH signature.	25.00	25.00	95.30	30.90	22.90	22.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.97	0.71	-4.87	5	8	2011-09-20 03:51:40	2011-09-20 04:51:40	1	2	7	0	5	11	0	143.90	36	90.99	CHANGED	VDPAVSRAKFDR-IGpFcspAsAYRtQGCFLIEAsFPTAFFIFAsPKV+PplIGAAVEIDFoNYDLRPPSVVFVDPFTRpPlARKDLhLsMLRRPpLPGTPP-MISVLhQQpALSLsDFLQANSsEcTPFLCMAGVREYHDNPAHSGDsWLLHRGSGEGCLAFILDKIIKYGTGPVE	..............Vc.tlSRApF-RpluphpspssuaRhpGhhLlpApaPsh.hIFssspltP....htlclshsNaDhpPPSVshlDs.Tt.............ct.tLstsPPthhsshht..........pApssptpPFlCMtGsREYHspsuHoGD.W.haRGSG-hsLuhIL-pIh+hhpssl...........	0	1	3	4
+14305	PF14456	alpha-hel2		Alpha-helical domain 2	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	An alpha-helical domain found in gene neighborhoods encoding genes  containing bacterial homologs of components of the ubiquitin  modification pathway such as the E1, E2, Ub and JAB peptidase  proteins.	25.00	25.00	34.60	28.10	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.62	0.70	-5.66	11	36	2011-09-20 04:45:34	2011-09-20 05:45:34	1	2	31	0	19	34	1	298.60	19	85.51	CHANGED	lsslsLuhhctGshptu-l..s.ssss-hhtpslptWhcsphsshthhs.............t.sssss.hhppsssss.ps.hhhshshssp.lahl....csplpsLcuspPsLupslhsllpcuuups.htlhoPshhhshhuhhaWcucs...Dpcpshphhctps-..sEtthpthh.s.sh.................hhphhsthspphhph.pptphphhtppcshssplssAlscltshlpctp.c.p.s.hshssst.tp...........sltsushltWc-s-hspcllDDahEhttpuusuppt.shl.ls..ssspulpphhcshcthhphhtul-cLLshlup	............................................hhhhhhptsslp.sDl..s.ssstchhppuhptWhpcpsushphlphth.........ht.stsththhpsssc.ss.ps.lahshshsp...s.latl....tsplcsLcsspPsLutTslsllpcAuths.h.lhTP.shhhshhuhha.WcG-s...D--sshphhpcp.t-s..s.tphpthhsu.sh.......t.........hhphh.chhtpshph.t.pp...hphh..tpppshhtpl.....ss.....tlt.....plts.........h.lptsphp.....thhtsshpsp...........shh.hshlthpp.s........-hstcllDDah-hhspus.spsh.shl.ls..ssspultp.hpchptthphhptlDpLlshlu...........................	0	4	10	16
+14306	PF14457	Prok-E2_A		Prokaryotic E2 family A	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in several bacteria. The active site residues are very similar to the eukaryotic E2 proteins [1,2]. Members of this family are usually fused to E1 and JAB domains C-terminal to the E2 domain. The protein is usually in the gene neighborhood of a gene encoding a distinct metallobetalactamase family protein [1].	25.00	25.00	27.40	26.70	22.90	22.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.68	0.71	-4.78	12	50	2012-10-02 15:28:41	2011-09-20 18:18:15	1	5	48	0	22	55	8	146.50	22	21.40	CHANGED	ttchhtshhtptsstsht.htspttptshthphhVths.psshsstssssI+phEsl..hhhssshshphP.shhLRpDFPhp........sH.p.sh.sps......ss.Clh-ssh.....s-hhhphsh.....pullpplhhWLpcuApGsLhpsspshEPhhhsstss.hlhs.shthtttss	...................................h................ht..th.t..p.ht..t.h.phhl.hsspsthts.ssssl+phEpl.hlhhsss..hshssP.s.shRpDFPsp.......hPHlpss..st.......hplClacssh.....s-h.hshuh.....puhls+lhtWLpcAAtspLpp.ppshEshhh.s..t.lh..........s..........	0	9	16	20
+14309	PF14460	Prok-E2_D		Prokaryotic E2 family D	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in several  bacteria. Members of this family lack the conserved histidine  of the classical E2-fold. However, they have an absolutely conserved histidine carboxyl-terminal to the conserved cysteine [1,2]. Members  of this family are usually present in a conserved gene neighborhood  with genes encoding members of the Ub modification pathway such as  the E1, Ub and JAB proteins. These neighborhoods also contain a  gene encoding a rapidly diverging alpha-helical protein [1].	25.00	25.00	28.90	28.50	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.22	0.71	-4.80	17	151	2012-10-02 15:28:41	2011-09-20 19:31:56	1	1	122	0	43	142	4	171.90	23	72.96	CHANGED	shpshhphlctlspp.....hshssalss.ssLs......hussthhWWs...........PsspRtlaFcst........thtppstslPhPuLVFhsstp..........shhVaAl+ss.cPs.sTpLapsPaaNVappGplChGs..splP.ctssssphpsWcttFFsSt..............FTHPNstspphhht......shshapchh-sph.psFPpssLlshc	.............................................t..............t..........t.hh.s.shLh.........huspphlWas...........PstpRplaFtp..........hthtstpsshPsllatss.tp..........shpVaAl+s...s.cP.stsT.LapsPahNV.....h.s.p.GplChGs..sp..l..P...chp.s...hpt.lptWcphF.a.sSt..............Fo.H.ssspp............hhphhtphhct.t..psFstphLh...t.........................................	0	11	31	39
+14311	PF14459	Prok-E2_C		Prokaryotic E2 family C	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A divergent member of the E2/UBC superfamily of proteins found in  bacteria. Members of the family contain a conserved cysteine in place of the histidine of the classical E2/UBC proteins [1,2]. Members of this family are usually fused to an E1 domain at their C-terminus. The protein is usually in the gene neighborhood of a gene encoding a JAB peptidase and another encoding a predicted metal binding domain [1].	25.00	25.00	83.70	82.40	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.59	0.71	-4.07	4	5	2012-10-02 15:28:41	\N	1	1	5	0	3	5	0	129.40	59	25.17	CHANGED	AFDDQAASCAEGQATLDLAVRLLARLYPVLAILPLGSAAShQAQALERLAKSINPKlGIRRSGKS.AolClVAGsTRPsLRCPTFFhGSDGWAAKLSRTDPVGSGSSLLPYGAGAASCFGAANVFRTIFAAQ	.....AFDDQAASCAEGQATLDLAVRLLARLYPVLAILPLGSAAShQAQALERLAKSINPKIGIRRSGKS.ATlCVVAGsTRPsLR.CPTFFlGSDGWAAKLSRTDPVGSGSSLLPYGAGAASCFGAANVFRTIFAAQ..	0	0	2	3
+14312	PF14461	Prok-E2_B		Prokaryotic E2 family B	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in several  bacteria. The active site residues are  similar to the eukaryotic E2 proteins but lack the conserved asparagine [1,2]. Members of this family are usually fused to an E1 domain at the C-terminus. The protein is usually in the gene neighborhood of a gene encoding  a member of the pol-beta nucleotidyltransferase superfamily [1]. Many of the operons in this family are in ICE-like mobile elements and plasmids [1].	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.60	0.71	-4.40	15	108	2012-10-02 15:28:41	2011-09-20 21:03:45	1	3	103	0	27	835	18	129.40	22	23.12	CHANGED	t.....h.pasps.sphhttsphsppssptshhtphhht.............pssshslpLVhscp.FshlPstlhls.-.pph...l.sHhts.s...GtLClh...ptsh-papssusst-ll.cphpplLp.pshsuss......ptchhuEasuYWptppssh........hh	..........................................................................thhhh.h..h...................................putshsltlsl.ss..a..t.h.P.th...h.lp...p.s..cphh.......hl.PHlph..s.....upLChhsp.psshs.sps....cush.t-s....h.cphpthLc..sulsusp............cs-htsEFtuYWptppp....h.....................................	0	7	18	21
+14313	PF14462	Prok-E2_E		Prokaryotic E2 family E	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteristic catalytic residues of the E2 enzymes [1,2]. They are usually fused  to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as  the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.	25.00	25.00	25.70	25.40	21.80	21.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.50	0.71	-4.53	5	36	2012-10-02 15:28:41	2011-09-20 22:59:24	1	4	35	0	15	40	1	123.80	31	52.33	CHANGED	LPEsDccYL-o+GaTaEsVsDGu++Glll+pFpLPpG+FssspVDlLllLPsGYPDssPDMFYlpPsL+LVsGs+hPpAo-sscpFpG+sWQRWSRH...NssWRsGlDGlaTMLKRVEcALcsAs	...................L.ptDppaLcshGhpa....Eslt-uutphll.lcsasLP.......pG..Y.....stsp.........s-lhlhlPs.uY.Psstl.DMFYspPsL.......phs..sGtt.......lP.s.....sp.sscshp...G+sWQRWSRH...pssWcP...shDslhTalthl-psLttth.........	0	4	8	11
+14314	PF14463	E1-N		E1 N-terminal domain	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	An uncharacterized alpha/beta domain fused to E1 proteins. This protein is usually present in gene neighborhoods with genes  encoding a JAB protein and a predicted metal-binding protein. In related E1 proteins, the E1-N domain is replaced by an E2/UBC superfamily domain [1].	25.00	25.00	46.30	45.70	24.60	21.70	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.87	0.71	-4.62	2	3	2011-09-21 18:21:18	2011-09-21 19:21:18	1	1	3	0	2	5	0	148.00	34	32.41	CHANGED	M.pssQpNAhMLAulLGssEs-AuERLsRsVLlTAsPGhtsuhhst.sthlh.RTVtVs.pp.sp-spLELVIG-sssRTsh.RlaAslsutGAssslcPVu+huG..PHsLhAAsAACssuAssl+hllDsssLPtsthPhRLDasQLGVP	M.pssQpNAhMLASlLGlsEsE.AuERLsRoVLlTAPPGsssA.thAp-VtALLuRTVsVVtpSsss-PsLELVIGDVsPRTS.usRLYAuluSsGATlulcPVuRsuGP.PHuLLAAlAACsVSAAVl+tVlDss-LPtVchPLRLDFDQLGVP.	0	1	1	1
+14315	PF14464	Prok-JAB		Prokaryotic homologs of the JAB domain	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [1]. Prokaryotic JAB domains are predicted to  have a similar role in their cognates of the  ubiquitin modification pathway [2,3]. The domain is widely found in bacteria,  archaea and phages where they are present in several gene contexts  in addition to those that correspond to the prokaryotic cognates of the eukaryotic Ub pathway. Other contexts in which JAB domains are present include gene neighbor associations with ubiquitin fold  domains in cysteine and siderophore biosynthesis, and phage tail  morphogenesis, where they are shown or predicted to process the  associated ubiquitin [2,4]. A distinct family, the RadC-like JAB domains are widespread in bacteria and are predicted to function as nucleases [5]. In halophilic archaea the JAB domain shows strong  gene-neighborhood associations with a nucleotidyltransferase  suggesting a role in nucleotide metabolism [5].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.66	0.72	-4.46	111	2146	2012-10-10 14:49:21	2011-09-22 01:37:47	1	14	1332	8	470	3074	346	105.60	29	49.36	CHANGED	stphhptlhtpupps.....hPpEssGlllGpt.....................tpphhhhthh.......................................ssppphphht.................ttpppshphluhaHSHPssss...hPSppDtphstt..................shhllssh............th.........shphh	...............................................................................................................................hp...h.ptlhtp.upts.....hP.tEsCGhlhtp............................ptp.hh.h.s.hs...............................................................hcPpt.hhcht.................................hts-hps-lVulhHSHP..s.....uh.....s.....h.S...csD+ch.phpss............hsaallsps.....................ttpthtsh.....................................	0	149	304	409
+14316	PF14465	NFRKB_winged		NFRKB Winged Helix-like	Godzik A	adam	de novo domain prediction, confirmed by X-ray structure determination	Domain	This domain covers regions 370-495 of human nuclear factor related  to kappaB binding (NFRKB) protein.	22.20	22.20	22.20	28.60	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.45	0.72	-4.17	10	81	2011-09-23 07:25:46	2011-09-23 08:25:46	1	5	64	2	52	80	0	100.70	48	8.17	CHANGED	FFSLLRDllsSTspH..R..Lo..h..LcppLpsWp.ps...PsusLN-Wao.pss.D.WopLLpSAlpFLoG..-sss.hPs-FVPYlEaKsphs.YQWIGAuRDSD.ucLssLCphW	.......................FFSLLh-llhhcupso..Ls..h..LE-+VhcWQ.uS.....PASsLNsWaS.hsP.s.WucLVhsALpaLAG.........-sps....lP.S.....uFsPaV.EaK-csQpW+hlGt..upDs-.K-LuALhQlW...........	0	12	15	32
+14317	PF14466	DUF4425		Domain of unknown function (DUF4425) 	Godzik A	adam	BVU_3708 from Bacteroides vulgatus, JCSG target GS13500	Domain	A small family of bacterial proteins, found in several  Bacteroides species. Structure determination (NMR and Xray) shows an immunoglobulin beta barrel fold.\	Multiple homologs have been found  in human gut metagenomics data sets.	27.00	27.00	28.60	111.90	24.60	23.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.59	0.71	-3.98	7	32	2011-09-24 22:47:10	2011-09-24 23:47:10	1	1	30	5	3	26	0	119.80	39	79.95	CHANGED	tslslhhullhVSCus-Dspsss..psula+IslctSGc.cshthulhlssss.....sKlhsE.sGp.lupShss...chhss+hohpTstpsh.hTstGslhSppc..ustpLphhV..YhDGKEV.p.	.pslhlshuLlhluCsc--ppsss...+uGhY+IslpQSGshcSFcsSVslsuss....ss+Lhs-.sGc.lusuhSls..EhtosKsohsTstsuh.hTsuGulhStp-..uscpLplslhsYpDGKEVp+p.	0	1	3	3
+14318	PF14467	DUF4426		Domain of unknown function (DUF4426)	Godzik A	adam	Pseudomonas aeruginosa PA0388, JCSG target SP19004A	Domain	Members of this entry are found mostly  in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase  RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine  biosynthesis protein MetW. On the other hand, in most Vibrio  species it appears as a part of a conserved operon involved in possible response to stress.	25.00	25.00	79.60	79.40	19.90	17.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.33	0.71	-4.31	62	249	2011-09-24 22:49:33	2011-09-24 23:49:33	1	2	249	4	64	191	80	120.60	46	83.76	CHANGED	phcphG-h-VHYsuFsSTFLsPclApsYslpRSchpullNIoV.lcps...ttsp.suh..sAploGpspNLlGptppLsF+ElcEGs.AIYYlAphsasscEphpFpIslpsssp..stslcFpQchas-	....QhcsltDh-VHYsAFNSTFLTPcVApuYpLpRusYpullNISVLDpu..ph...up.sAs..pAploGpA+N.LlGphppLsF+cV+..EGs.AIYYLAEhPhss-EhlsFsIcVcsGsc.hstpLpFsQKFYs-...	0	13	28	48
+14319	PF14468	DUF4427		Protein of unknown function (DUF4427)	Godzik A	adam	PSYMP_19184 [Pseudomonas syringae pv. morsprunorum str. M302280PT]	Family	This domain is often found at the C-terminal of proteins with  Pfam:PF10899 domain, for instance in STY1911 protein from a  multiple drug resistant Salmonella enterica serovar Typhi CT18.	22.70	22.70	23.20	24.70	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.51	0.71	-4.43	3	112	2011-09-25 08:35:22	2011-09-25 09:35:22	1	2	109	0	2	45	0	125.80	91	33.30	CHANGED	LSuusVKsYsccIN-YIspLYSsKDahsDsYuhEFGNAWVWIHDNQs-VTRALLQcGhVSVN+EGRYLLKlsLtuScWPLR+KEshAKaVA+WL+pRFsLEuGYFSVhGu-DYDcIPaYNssLcENHPFYNs	.......LSASKVKNYADSINDYVSELYSKKDFLNDsYAMEFGNAWVWIHDNQSQVVRALLQAGMIKVNKEGRYLLDVNLASVDWPLRRKEAFASHVAGWLKHRFDIEAGRYSVpGKDcYDAIPSYETPLK-QHPFYNH.....	0	1	1	2
+14320	PF14469	AKAP28		28 kDa A-kinase anchor 	Jaroszewski L, Godzik A	adam	Q86UN6 A-kinase anchor protein 14 isoform a [Homo sapiens]	Family	28 kDa AKAP (AKAP28) is highly enriched in human airway axonemes.  The mRNA for AKAP28 is up-regulated as primary airway cells  differentiate and is specifically expressed in tissues containing  cilia and/or flagella [1]. Homologs of AKAP28 are present in all  animals and in some, including mice the AKAP28-like domain are  preceded by another uncharacterized domain 	21.60	21.60	22.10	22.00	20.20	21.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.51	0.71	-4.54	15	76	2011-09-26 09:21:28	2011-09-26 10:21:28	1	2	64	0	52	77	0	111.90	30	49.52	CHANGED	pWhTtGEFshpsulppI--FlspWpls...csWlass-.lp+--h.+uphYhhcV+aShPTtRpPlPpAoApVhFsIpVSKhcPtchPV.VoYhFEup+Lla.....Rssps.pFREpWL+cIlcoKhthh-	..............................hhoht-FphppuhppIccal.p.pWphp..........csW.latscalpccsh.puhhYhapV+aShPTsppPhPpsoAslaFhl.p.loKhcP.ph.Pl...lh......YhhEspphl+.....Rst.s...pFp-pWlcslhcsKh.hh.....................	0	22	24	36
+14321	PF14470	bPH_3		Bacterial PH domain	Bateman A	agb	Jackhmmer:C8LJ44	Domain	Proteins in this family are distantly related to PH domains.	23.00	16.00	23.00	16.40	22.90	15.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.14	0.72	-3.72	68	691	2012-10-04 00:02:25	2011-10-26 16:08:13	1	14	480	0	99	818	44	95.00	24	64.96	NEW	Lp..ssEplhhhs...hu...hh.p......................tpsshllsTs+Rllhhsp..phhtt.hp.h.pshsapcIsslphc..psl............hh.sc.lphts...sspplpl...p.l..s+sss.cphhphlpp	..............................................tE.h...h....hs....hhch..................h.sthpGhhlsTNc.R..Llhhth....sh.tp...hh...h....c..ph..s..ascIpsl.chc...................hs...pp..Ihhph...sttp..l.h...cpI..ppssV.phhlchlp............................................	1	34	63	82
+14322	PF14471	DUF4428		Domain of unknown function (DUF4428)	Bateman A	agb	Jackhmmer:C9XSR9	Domain	This putative zinc finger domain is found in uncharacterised bacterial proteins.	27.20	27.20	27.60	27.50	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.82	0.72	-4.22	24	71	2011-10-26 15:21:41	2011-10-26 16:21:41	1	8	57	0	10	70	4	49.50	28	20.98	NEW	pCslCspclGh..h...pt...hclpDG.h.lCcsChpKl....ssh.....h.pshph.p.hTlpcI+ch	..CslCspclGh..ht.....KlpDG.a.lCcsChpKl....psh.....h.tshp.h.pphTlpplpp............	0	6	9	9
+14323	PF14472	DUF4429		Domain of unknown function (DUF4429)	Bateman A	agb	Jackhmmer:Q9L067	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and viruses, and is approximately 90 amino acids in length.  This domain is often found in two tandem copies.	25.00	0.00	25.10	5.60	23.80	-999999.99	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.17	0.72	-3.69	66	192	2011-10-26 15:23:52	2011-10-26 16:23:52	1	7	87	0	61	208	3	93.40	26	61.81	NEW	hsFDGpp.lplphs...htstth+pu...tG.spslslsslsuVpac.s.....sth....................................................tsGaL..Rhhhts....................ussstst.................ssppDPtsl...hhs.tcptthshhhsstVps	...............hsFDGcs.lplpap...hts.phptt..hG.-pplPlssluuVphc.P....sth....................................................tsGhL.Rhhh+s................................ussshtths...............ssspDPhsl...hhh.tcp.t.st.hsstl..t....................	0	19	48	59
+14324	PF14473	RD3		RD3 protein	Bateman A	agb	Jackhmmer:RD3_HUMAN	Family	RD3 is a human protein that is found preferentially expressed in the retina [1].  Mutations in RD3 causes Leber Congenital Amaurosis type 12 [2].	27.00	27.00	31.20	30.80	23.20	18.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.61	0.71	-4.68	17	73	2011-10-26 15:48:09	2011-10-26 16:48:09	1	1	43	0	55	70	0	130.30	43	66.10	NEW	hsWh.......p.hsp.s.ppsupRssp-.........lVscsLhhELphpl+ctE+.ppE+EpEtR+tc....otsDYSWLhoss...+tphplsssE+hpLEsLCu+lpPspsu.lIsRFRcllspp-spspElsplF+sVLp-hLpphccptp	..............sWh.......+.hspss..+.opRssuE.........hVh-TLMhELshpl+EsER.pcERcsEhR+hc.....TGVDYSWLsSsP...+ssaslossE+LQLE-lCuKlpPspCGslI.RFRpllAEp-P-spEVsplF+uVLp-sLcphcpEp......	0	7	15	33
+14325	PF14474	RTC4		RTC4-like domain	Bateman A	agb	Jackhmmer:Q59X99	Domain	This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres [1]. This domain is also found in proteins that contain a DNA-binding myb domain.	21.80	21.80	24.40	23.40	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.65	0.71	-4.18	38	169	2011-10-27 11:39:00	2011-10-27 12:39:00	1	4	127	0	125	175	1	120.40	28	26.24	NEW	ILsspp....sShY.............+shhcsphps.u+cpshphs...............t.thpphssGYYG.+Gtph.......hsptlhs+.auscLc+hAspsp........llpthGsssFsQtVLVPElhlhLltEDM......sls.......s.cc....................ARpIhc-Ss-hGshls-p	...........................................h..t...sShYhshhcpthpp..uppth.hphs.................thpph.ssGY..YG.+Gtph.............hsptlhsc..ats..t.lcphsstst........llp..hh....G.sssasptVLVPElhhhLlhEDM.........sls.........s.cp............................Acpllc-SschGplls..............	0	28	59	104
+14326	PF14475	Mso1_Sec1_bdg		Sec1-binding region of Mso1	Wood V, Coggill P	pcc	manual	Domain	Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction [1], and this binding domain is towards the N-terminus of Mso1. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane [2].  Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p [3]. The C-terminal region of Mso1 (not built) assists in targetting Sec1 to the sites of polarised membrane transport [4].	29.10	29.10	31.30	30.40	28.60	27.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.07	0.72	-4.55	22	111	2011-10-27 17:28:36	2011-10-27 18:28:36	1	3	109	0	80	103	0	43.90	40	17.97	NEW	Sulpplp..l...p....sEpDGDTtsDTlVH+sLlpYYppp..tpsaPsWL	...................phtph.....h.....p.........sEs.D.GDoEDsThlp+sLhsYYscK..GpsFPsWL	0	13	39	67
+14327	PF14476	Chloroplast_duf		Petal formation-expressed	Coggill P	pcc	Pfam-B_480 (release 25.0)	Family	The members of this plant family from Arabidopsis thaliana appear to be proteins found in the chloroplast, expressed in the pollen tube during the petal differentiation and expansion stage. The function is not known.	25.00	25.00	44.50	25.00	21.90	21.30	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.03	0.70	-5.63	14	101	2011-10-28 14:10:21	2011-10-28 15:10:21	1	4	16	0	67	104	1	250.10	52	75.27	NEW	KLaAlhEAVADRlEMHcNIGcQRDNWN+LLLsSlNslTLTAAsMAGLA...stuusshhALKlSSTlLasAATGhhslMNKIQPSQLAEEQRNAsRLF+QLcppIcssLulsss........spsDVp-AME+VLALD+AYPLPLLGuMLEKFPpoVEPAsWWPppcppptcppt................tttpuNGWSpELE-EMRcllpVLKtKDpp-Yl+LGclALKlNKlLAIoGPlLTGlAAluSAFlGss.....ssWAuhluVssGALAosVNTlEHGGQVGMVFEMYRssAGFFphMEEoIESslpEp-Vc+RENGElFEhKVALpLGRSLS-L+	......................pLhulhEtssDRhEMHc.IGcQRsNWNpLLLpShN.lTLsAusMuulA....s.sussllALKhSuslLh.uAsshhhhhNKIQPSQLsEEQRNAsRLa+pLptpl.pthluhsss........optDVppsh-+VLALDpAYPLPLLs.sML-KFPpphEPAhWWPppc.ptt.pptt....................t.psNGWs.-LE.EMRclltVlKtKD.p-Y.+lGplsLplNKhLAluGPhLsGhAAhuouFlGss.......tsWushlulhsGuhAusVNshEHGGQlGMVFEMYRssuGFaphhpEsIEuslpEt-lt+RENGElFEhKVALpLGRShStL+.......................................	0	3	46	59
+14328	PF14477	Mso1_C		Membrane-polarising domain of Mso1	Coggill P	pcc	PF14475	Domain	Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction [1]. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane [2]. Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p [3]. This C-terminal region of Mso1 assists in targetting Sec1 to the sites of polarised membrane transport, the SNARES and Sec4 [4].	23.20	23.20	23.20	23.20	22.50	18.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.78	0.72	-3.64	7	18	2011-10-28 14:29:35	2011-10-28 15:29:35	1	2	18	0	12	17	0	60.30	31	34.86	NEW	hSup......uSsslp.....+suSclpDsaNSp+DsS.hp..Gosptuh...PAps.sssustpGS.LRu	........................................................tusshp........RSSSRLQDhYNKSRQQS..hPGsGYso................................	0	2	7	12
+14329	PF14478	DUF4430		Domain of unknown function (DUF4430)	Coggill P	pcc	JCSG-Target:417407-SP17946A	Domain	Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.	30.00	30.00	30.20	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.20	0.72	-3.92	123	701	2012-10-03 10:59:06	2011-10-28 15:57:49	1	52	462	4	173	592	41	69.30	29	19.69	NEW	usolh......csLc.....p....pt...plpt..p...pt.........thG....alsuI...sG.....h.p.p.........c..tsss.ph.....WhapV.N.Gphssh.....Gusphpl.c.sGDp.lpat	..............................................................polhslLp.......c........st....clct..p.......s............G.....alsuI....sG....................ltp...............c..ssp.sh.......WhapV..N.Gphssp......GAsph.....pl.c.sGDplpa...........	0	62	111	129
+14330	PF14479	HeLo		Prion-inhibition and propagation	Greenwald J, Coggill P	pcc	Pfam-B_407 (release 25.0)	Domain	This N-terminal region, HeLo, has a prion-inhibitory effect in cis on its own prion-forming domain (PFD) and in trans on HET-s prion propagation [1]. The domain is found exclusively in the fungal kingdom. Its structure, as it occurs in the HET-s/HET-S proteins, consists of two bundles of alpha-helices that pack into a single globular domain [1].  The domain boundary determined from its structure and from protease-resistance experiments overlaps with the C-terminal prion-forming domain of HET-s (PF11558 [2]. The HeLo domains of HET-s and HET-S are very similar and their few differences (and not the prion-forming domains) determine the compatibility-phenotype of the fungi in which the proteins are expressed. The mechanism of the HeLo domain-function in heterokaryon-incompatibility is still under investigation, however the HeLo domain is found in similar protein architectures as other cell death and apoptosis-inducing domains. The only other HeLo protein to which a function has been associated is LopB from L. maculans [3].  Although its specific role in L. maculans is unknown, LopB- mutants have impaired ability to form lesions on oilseed rape. The HeLo domain is not related to the HET domain (PF06985) which is another domain involved in heterokaryon incompatibility.	23.20	23.00	23.30	23.20	23.10	22.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-9.98	0.70	-11.20	0.70	-4.58	65	227	2011-10-28 17:51:32	2011-10-28 18:51:32	1	30	76	5	198	232	0	189.70	16	32.69	NEW	GlulGsh...ul..............uulFssslc.....saphlpsu.........+sau.cDhphhp.l+L-lpchRLhpWGcul.....GLhpss.tpp...........................hssthh...tptlpplLspIpplhp-s..pphpp+athptsssstt................................................................................ppphpphspp.tppp....pshhp+sp......WslhDKcp........FppLlpclpshs-s.LpsLh..Pstptpp............phtptchpth..pptpsLphLpcs	........................................................................................h.sh.ul........htlapsslp...................shphlpss.............pphs.p-hphht.hcLclpphRLhtWucss.....Gl.psttttp......................................................tp..h...tptlhplLtpltphhpph..pphp.p+ath.tst.ttt...............................................................................................................................htthpthhtp.tppp.........hphhp+hp......Ws....lhD+pp........hptllpphpthsspLpplh.....s.ttp.p..........................................................................................................................................	0	27	88	173
+14331	PF14480	DNA_pol3_a_NI		DNA polymerase III polC-type N-terminus I	Eberhardt R	re3	Pfam-B_853 (release 23.0)	Family	This is the first N-terminal domain, NI domain, of the DNA polymerase III polC subunit A that is found only in Firmicutes. DNA polymerase polC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria [1].  Purine asymmetry is a characteristic of organisms with a heterodimeric DNA polymerase III alpha-subunit constituted by polC which probably plays a direct role in the maintenance of strand-biased gene distribution; since, among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased [2]. It has been predicted that the N-terminus of polC folds into two globular domains, NI and NII. A predicted patch of elecrostatic potential at the surface of this domain suggests a possible involvement in nucleic acid binding [3]. This domain is associated with DNA_pol3_alpha Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF11490.	22.00	22.00	22.60	22.00	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.31	0.72	-4.34	58	1166	2011-10-31 08:26:54	2011-10-31 08:26:54	1	22	1163	0	129	779	4	76.00	29	5.33	NEW	cpFphLhpplp..hssch...thhpsu.plp+lslpcps+pWcFplphcplLPhchapphpppLpps.Fpphs.plphplps	............ppFplLhsQlp...hssph.psthlpsu.pIc+lsVppts+hW-FHlshsplLPh-hahthpptLppp.Fpchu.psshplp..............	0	42	81	105
+14332	PF14481	Fimbrial_PilY2		Type 4 fimbrial biogenesis protein PilY2	Jaroszewski L, Godzik A	lukasz	Pseudomonas aeruginosa PAO1 gene PA4555, JCSG target SP18988A	Family	Members of this family were experimentally shown to be involved  in fimbrial biogenesis, but its exact role appears to be unknown.	25.00	25.00	118.80	118.60	22.00	20.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.41	0.71	-4.67	9	19	2011-10-31 17:44:58	2011-10-31 17:44:58	1	1	18	2	2	11	0	112.70	67	99.54	NEW	MKsL.hL......LALAsPshsaAp-spTFEsuGVV.-VplEpsLVsIDtphYRLPNussps....GhPslFQV+PGSVVSaSGoVSpPhspIssIYIhKQhS...hu....cEp...tuE.ps+	.MKVLPML......LALAVPGLCWAE-PQTFEGAGVVFEVQVEKNLVDIDHRLYRLPNSTVRN....GMPSLFQVKPGSVVSYSGTVSQPWSTITDIYIHKQMSEQELAEMIEKEQPRQDGEEQPR..	0	1	1	2
+14333	PF14482	Cut8_N		Cut8 proteasome-binding domain	Eberhardt R	re3	Wood V	Family	In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome [1]. Cut8 comprises three functional domains. An N-terminal lysine-rich segment (this entry) which binds to the proteasome when ubiquitinated, a central dimerisation domain (Pfam:PF14483) and a C-terminal six-helix bundle (Pfam:PF08559), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding [2]. Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8 [1]. Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome [1]. In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 [1]. Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum [1].	22.00	22.00	23.70	23.70	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.84	0.72	-3.97	19	98	2011-11-01 13:47:55	2011-11-01 13:47:55	1	3	96	0	68	85	0	55.20	33	17.09	NEW	phpspps.tpR...KRpus--.......pp..hsP....ssp.t........h.spth.........................ts++Kh+.tsplpGpP	...........ppss.ssR...KRKA--D........t.sschohSP.......osSPu........hssRsls.........................sp++hR.psplsGRP.	0	10	27	51
+14334	PF14483	Cut8_M		Cut8 dimerisation domain	Eberhardt R	re3	Wood V	Family	In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome [1]. Cut8 comprises three functional domains. An N-terminal lysine-rich segment (Pfam:PF14482) which binds to the proteasome when ubiquitinated, a central dimerisation domain (this entry) and a C-terminal six-helix bundle (Pfam:PF08559), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding [2]. Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8 [1]. Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome [1]. In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 [1]. Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum [1].	22.00	22.00	22.30	22.30	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.54	0.72	-4.15	19	126	2011-11-01 13:49:00	2011-11-01 13:49:00	1	5	124	3	91	116	0	37.70	39	11.94	NEW	LPLsRLLEsLDpspLpslLpslsppHP-lupplhptsP	..LsLsRLLEoLDpspLpslLpslsc+HP-lspEVhppuP.............	0	14	41	74
+14335	PF14484	FISNA		Fish-specific NACHT associated domain	Eberhardt R	re3	Jackhmmer:A5PF24	Family	This domain is frequently found associated with the NACHT domain (Pfam:PF05729) in fish and other vertebrates [1].	22.90	22.90	23.40	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.26	0.72	-4.00	25	1153	2011-11-03 14:27:53	2011-11-03 14:27:53	1	57	42	0	826	627	0	71.30	49	11.79	NEW	paKssl++KapslhEGsuppussshLNcIYT-LYIsEGcSspVNpEHEVh.QhEppu+ppssp-TPIpCpDIFp	.............phKssLK+KapplFEGIuptGssTLLNcIYT-LYITEGtotpVNpEHEVR.QIEssS...Rp....p..............sp.-oslcs..cDlFc..................	0	2	385	784
+14336	PF14485	DUF4431		Domain of unknown function (DUF4431)	Coggill P	pcc	Jackhmmer:E7X0E8	Domain	\N	24.00	24.00	24.50	24.00	22.90	21.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.20	0.72	-4.35	23	127	2011-11-04 10:52:06	2011-11-04 10:52:06	1	4	112	0	11	66	0	49.00	47	13.24	NEW	plQLsl.sssphshhcp.....hlGKcVpVs.GclhhupouaHaTPlLLs.lspls	..........h.VQLlL.sPEcashapp.....alGK+ITlp.G+VMlAcShaHhTPVLLs.lpc..p....	0	4	7	9
+14337	PF14486	DUF4432		Domain of unknown function (DUF4432)	Coggill P	pcc	JCSG_target390294_A6THE6	Family	\N	32.00	32.00	32.30	32.40	31.50	31.30	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.59	0.70	-5.87	63	706	2012-10-02 23:57:29	2011-11-08 15:18:22	1	2	605	3	123	495	53	292.50	33	85.99	NEW	scGschlplps...uGLphsllPsRGMDlh.....csphp...Ghs.luWpSPs.s.hlsPshhs...psGhGWLcuFs.shlspCGLptsGsPs..s.-s..........ut..............h..........sLHGRlustPAcplsh.ph..p...-..p.s.htlplpGplcEsphFGtsLpLppplpsphGps...plplpDplsNpust.spsh.hLYHhNhGhPlL-csuchh..................hPs.pplsst....s...spAtp...shssapphtsPps...s.a...sEpVahhc..tuDtsG.pshshlhNtph...shG...lslpFspppLPhhs.WKshss..tsYVhGLEPu.Tshshs.+sht+cpGplhtLtPGEs+saplphpl	................................s.pGlculclpN..upG.plhllPhhG....Ih.....cA..pac...Gps..Lshpshh..p....pPt.ht.......ph.lcoas.sahh+sG....L.....ts....GsPu....s.-D......................ha..........sLHGchsssshcc.shl.ch..c...s.....tlplsGchc.shs.F.Gcca.hspsslshchuSs...hFcIp.pVTNhu.sh.shPLQhhhHhNauas.......ssAphp.............................tPs..tphhsh....N....pch.hp.........G.s.s...hpols.tPph...h...............sEhVahhc...h.sc.......ps.psthth..hsscu........ps...hss+FsospLshhTpWhhhsup......ppshshuL...Pu.Tsp.P.-.G..hhst....pt.pGp.LhpLpPtpo+sFslohu.................................................................................................................	0	40	61	87
+14338	PF14487	DUF4433		Domain of unknown function (DUF4433)	Bateman A	agb	Jackhmmer:A0YHY7	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 201 and 230 amino acids in length. There is a single completely conserved residue E that may be functionally important. This family is distantly similar to Pfam:PF01885 suggesting these may be ADP-ribosylases.	22.50	22.50	23.30	24.20	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.41	0.71	-4.59	53	218	2011-11-08 17:28:40	2011-11-08 17:28:40	1	5	201	0	55	181	25	184.10	25	79.79	NEW	aHIsHlcNLsSIlpsGhLhucsplhppthshssIu.spIpp+Rhtp.slsstsutplt-YVPF...YFsPRSsMLYtI.ppss.....htttp...psIlhLtssl.ptlst.....t.phsFo..susAusphschhs.............sL...ppLt.pl-Wshlpu........p.Wp.........pp+ct+QAEhLlc.pphPhphlppIsVhspshtspVpphlttts....................hp.sVplpss....WYa	...................................................................aHhTHhcNLssIl..psGhLhucstl....hshsplu.s.lhphRtt......sh.ssshhpDaVPF...Yh.s.spS.sMLasl.pttps...........pt........ttslVhLsssl.chlst...........thsasao..sssAss.sh..sphh.s..............pl......spLt..lcas.hlpt...................cpapps........t...p..s.sp.pcppAEhLlh.pplPhphlpt..lsshspphhpplpphlt.hs.............h...h.hpst..hYa.............................	0	20	35	44
+14339	PF14488	DUF4434		Domain of unknown function (DUF4434)	Coggill P	pcc	JCSG_Target_393000_GS13553A	Family	\N	30.00	30.00	30.00	30.40	29.80	29.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.19	0.71	-4.52	39	420	2012-10-03 05:44:19	2011-11-09 11:13:28	1	8	375	0	32	218	17	167.10	53	52.21	NEW	loGTFlp.hp.s........c...........pshssspWcpchpth+plGhcsll.....lp...............hsuhps.tshhP.oph......t..h......s...shlphhLstAc+hGMclahGlhhss....paWc..p...pshph.......p..hthspt........lhcE.lhp..haup.at..uFt..GWYlshElspt...s............hss.......ssth....ptls.ph.hcplus.......shPsh..lSsahsst	...................MKGIIWQPQNRDS............QVTDTQWQGLMSQLRLQGFDTLV.....LQ...............WTRYGD.....AFTQP.EQR..................sLLFKRAAAAQQAGL....KLIVGLNADP....EFFM.HQ...KQSSAA..............LESYLNRL.............LAAD...LQQA.RLWSA.sPG..lTPD..GWYISAEIDDL....N..............WRS............EAAR....QPLL.TW.LNNAQRLIS.DVSAKPVY..ISSFFAG.N......................	0	10	23	26
+14340	PF14489	QueF		QueF-like protein	Bateman A	agb	PF01227	Family	This protein is involved in the biosynthesis of queuosine.  In some proteins this domain appears to be fused to Pfam:PF06508.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.67	0.72	-4.03	30	2821	2012-10-01 20:59:24	2011-11-09 15:46:40	1	7	2788	25	550	1754	742	79.10	46	38.24	NEW	PDFAolhlcYhPspphlEhKSLKLYLhSFRscshFHEpssNpIhcDllpthcPcalcVhucFsPRGGlshslhsppsctss	...................PDauolhIpYhss.p...l-pcuLhhYLhSFRpHs.-FHEpClppIhs.DLlchh.pPchLpVau+.aT.RGGlsIsPaps.s...sh......................	0	155	323	442
+14341	PF14490	HHH_4		Helix-hairpin-helix containing domain	Bateman A	agb	Jackhmmer:A0YV56	Family	This presumed domain contains at least one helix-hairpin-helix motif. This domain is often found in RecD helicases.	27.00	27.00	27.00	27.00	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.02	0.72	-4.22	189	1795	2012-10-03 02:11:09	2011-11-09 16:09:58	1	16	1618	4	349	1402	107	94.40	34	12.36	NEW	shpcpps..hcclhhhLppaGlss.p..hAh+Iapp..Yu..s.....pul..cllccNPYpLsp-l......pGlGFppADpIAp....p.h......GlstcsspRlpAulhasLpp.s.t.ppGHsa	.................................tppshcplhhhLpsaGlus..pluhpIapt..Yt..p.........co.l..pllcpNPYpLlcDI......cGIG...FppADplAc....p.l...................GIs.s..s...sscRl+Aulha.sLpp..sh.ppGcTY.....................	0	137	248	310
+14342	PF14491	DUF4435		Protein of unknown function (DUF4435)	Bateman A	agb	Jackhmmer:A0YK45	Domain	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 285 and 362 amino acids in length. This domain is sometimes associated with AAA domains.	27.00	27.00	27.10	27.20	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.79	0.70	-4.54	54	311	2011-11-09 16:32:35	2011-11-09 16:32:35	1	5	276	0	51	265	2	230.50	19	66.66	NEW	c.+lhsaVEuh..DD.h.aacslls..ph....ps.c...h...c.h.ap......................stGKcsVL.phhphh......ppt..sspshlh.hVDsDa..........Dhl.......h.tt.........ps.s...hla...pT.sYu.....IENhhs.hs.pulcclhsth.sls-..............hh.c..apphhppapctl..hslhl...a.hhhh......cpt.....phhshpps..l.ph..............ps.hphpph.hph.......phpplphp...hphpplpphh.p...th..............................c...ps...h.pplppclppl..s...ps..h.....p..hhh..pG+.....alh......hl.h...hlp.plhpph...pp..cppp	.....................chhhaVEGh...cDh.aapsl...ls..ph....ps.c.....h.....p.h.h.......................stGKppVlts.thl.......psp......hspshlu...hlDsD.a.................Dhl......httt..............psp....lahT.sas..........lENhhh...hs......pslcclhs...ph.....phss.....p......th.......hc...h.p.t.hh..pp.hp....phl.hslhh.h.hhhh...ppt.............thpph..l.ph.............pphphpph...p......p.tphphp...thhpplpphh.p...th...............................p...t....h.pthppphpth.....t...ts..h..........h....hh..pGH......lhp..l.h..hhh...htp..........pp...................................................................................................	0	15	34	48
+14343	PF14492	EFG_II		Elongation Factor G, domain II	Bateman A	agb	Jackhmmer:A0YMC3	Domain	This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679).	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.15	0.72	-4.13	129	11565	2012-10-02 20:07:24	2011-11-09 16:50:22	1	54	5577	56	3004	8396	3438	73.30	37	10.91	NEW	hPcPVlshAlcP...cs...csDp-KlupuLp+lhcEDPohplppcpETspslluGMGELHL-lhl-Rl+ccatl-lplup	...........................PpPVlphu.lEPKs......psDp-Kh............sp...........ALp.+LscEDPoh+lps.....cp.E...o...u...p...pl.....luG.....h.......GELHL-lll.-.Rhc+Ea..p.l-spht.t.............................	0	1071	1868	2539
+14344	PF14493	HTH_40		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:A0YXF4	Domain	This presumed domain is found at the C-terminus of a large number of helicase proteins.	27.00	27.00	27.00	27.30	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.76	0.72	-3.77	166	1114	2012-10-04 14:01:12	2011-11-09 17:27:19	1	26	983	0	236	851	57	91.20	26	16.58	NEW	sotphThpLa....p.p..G.holc-IAp....pRs......LphuTI.sHLschhpp..Gt.....l....s....l....p....ph..l..sp.....c.....c.hppItpsh.......pp..hs...........................s...p.......pL+sl+E..tLspp.hoYtpI+lshs	.................othhTaphh....p.p..G.holc-IAp....pRp......LphsTIpsHllchhhp..Gh.....h....s....h....p....ph......l.st.............-.....c..ptlh...p..hh.......pp...hp....................................s...p.........cL+.lK-..thst....p.loYhpl+lhl...............................................................	0	89	170	209
+14345	PF14494	DUF4436		Domain of unknown function (DUF4436)	Coggill P	pcc	Pfam-B_6430 (release 25.0)	Family	This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	23.00	23.00	23.00	23.00	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.69	0.70	-5.09	15	176	2011-11-09 18:28:06	2011-11-09 18:28:06	1	3	96	0	47	101	5	244.90	40	77.13	NEW	ushlhspo..ssshsps-suh..u-posVplslEclcossscLsVsVhVtPssuLlDschpsLssDluVRlpusss.u-lpascGphPushsss.lshsGchpsWPFDpYcoss......lss......-lhsGsGss+tshPupVchsGs.LsGWslshspsscss.........sssshplsLcRStuslsFslsIshVLIuLPslALhVAIphspsRRpFpPPhsTWaAAMLFAVVPLRNhLPGoPPhGuWIDhsVVLWVLlALVsuMllYIlsWWRph	...........................................................s..hhhpo...s...psshup..sDsTsVhl+hEpLpTltshLssplh.V.PssphlDpp.hp.sLpsDhoVp..lh.s.s.p.schpassGpLPu...hsss.lp.h.p..Gs....Pus..WPFDpYposs......lps...............plhhGu...u.............+t..h.s......pVp...hssp..L....G..Wslshs..t.Vu-us.................tssshhlsL+.....Ruhusls...........F..slsIshVL.Is.Lsslu...L.F.V.Al..QhhpGR.RpF...Q...PP...h..sTWYAAMLFAVlPLRNhLPGuP.P.....h.GuWIDhsVVlWVllALssuMVlYIlsWahch.......................	0	27	37	43
+14346	PF14495	Cytochrom_C550		Cytochrome c-550 domain	Bateman A	agb	Jackhmmer:Q55013	Domain	This domain is a heme binding cytochrome known as cytochrome c550, or cytochrome c549, or PsbV [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.73	0.71	-4.71	49	117	2012-10-03 10:02:11	2011-11-10 14:07:10	1	1	98	25	35	180	43	133.90	48	82.64	NEW	hcLDc.........pscTVsL.......sssGcTlsloscQlppGK+LFsssCupCHsGGl...TKTNPNVuLs.-sLuhAoPsRDNltuLVDYhKsPToYDGpcsIuElHPuhcSuDlaPcMRsLo--DLhslAGaILlpPKlhuppWG....GGK........lYa	.......................hpLscpohTVslsspGpTlsloscQlppG++LFsssCupCHsGGl...TKTNPNVuLs.EsLuh.A..T.Ps..RDNltuLVDYhKsPToYDGp-sIuElHPSlcSuDlaPcMRsLT--DLhslAGaILlpPKlsuppWGGGKh....................................................	0	10	26	33
+14347	PF14496	NEL		C-terminal novel E3 ligase, LRR-interacting	Coggill P	pcc	Jackhmmer:E7K2H2_PDB:3ckd	Domain	This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred [1].	23.00	23.00	23.10	23.40	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.43	0.70	-5.06	37	676	2011-11-10 15:41:18	2011-11-10 15:41:18	1	44	233	6	57	677	1	198.20	45	29.38	NEW	WLtssstps.p..phttWpshppEpsussFsphLscLppossaptts.....shpppVhphLpthspcspLRpphFshAtssp......toCpDplsltasshchshhl....tsscssph-ss.....LlphuRphaRL-tL-plApc+ltph.t...............sD-lEVhLAapspLtcsLsLss..spcMhahslSslopsDltpApspV.........ppppspthhpalup.pshWcshLcchpssca	...................................................Wh.s.pcps.....sp.W+uF..-pEppA..ssFStFLDRLu-T.ss+pss...........sF+cQVuAW....LtpLus...........s....spL..RppsFsl..At-AT.......tSCEDR.VsLsasphcpshLV....H.pApcGhaDsch..stLlshGREhFRLE.LEsIAR-..KV+pL..h............................................h...lDEI...EVaLAaQsh....Lt-pLpLoo.hsp-MRFas...VS.GVTssDLcsAEthV.........+stEpp-FpcWhuh.WuPWHsVLcRpts-ca......................................................	0	4	12	27
+14348	PF14497	GST_C_3		Glutathione S-transferase, C-terminal domain	Bateman A	agb	Jackhmmer:Q7WQ90	Domain	This domain is closely related to Pfam:PF00043.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.62	0.72	-3.52	199	1536	2012-10-03 01:14:49	2011-11-11 11:56:35	1	53	641	37	886	5329	1288	117.80	14	30.20	NEW	tpthphsh........hs.....Whs..................................................................tptsppcl.ptlphh.....sptL...stps...............alhGsp..h..................ohsDl....s...las....hl........tshp..at.....h..................tsh.......................p......lhp........ahsplpp	.....................................................................................................................t.........................................................................................................t..t....t...h...t...p...ts...p...p...c...l....p....h.h.pth..........pptL.........spps..................alhGsp.....................ohADl......s........l.au..........hL...................tsht......hs.....hs...........................pphs.......................sltpahpplp..............................................	0	254	427	678
+14349	PF14498	Glyco_hyd_65N_2		Glycosyl hydrolase family 65, N-terminal domain	Bateman A	agb	Jackhmmer:B5CKV7	Domain	This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	27.00	27.00	27.30	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.62	0.70	-4.68	86	1312	2012-10-02 23:57:29	2011-11-11 13:22:47	1	57	676	9	328	1063	38	230.20	29	29.24	NEW	LaaspP...............Asp..................Wp......cuLPlGNGplGAhlaGsss.....pEplplN-colWoG..uspssps.s..............................s.thlttlRphlhpscht.........pupplhtphhtstst.................t..YpshGsLhls............ts...pssss.............sYpRpLDLssulssssaph..su.............spa..........pR-hFsSh...PD.........sVlV......h+l.puspsttl.shslplsss...................psssssspssplphpGph.....................tssulpaputl+l.hssuGsl...tsps................sslplp....sAsplslllsssTsapsp	..........................................................LhYppP...................Asp.................................Wp...-ALPlGNGpLGAhlaGshs.....pEplQhNEco.lWsG......ustsps.sst..............................th.hL.p.lRp....hl....p.schp...........................tAp.p.Lhppphhu..p...........................up.Y.shGclhlc........................ths...tspho.......................sYpRpL-lspAlus..ssaph..su.......................spa...........pREhFsSh.....sc...................slll......h+h.ous.t........t.p.......l..sh..s..lplsps.......................................ppthhshsssplhh.p.Gps......................................................tpsslp..at....sh..h..th...htss.Gpl......ps.s....................spltlp...sAs.psslhlsutTsat.....................................................................................................................	0	123	253	301
+14350	PF14499	DUF4437		Domain of unknown function (DUF4437)	Eberhardt R	re3	Jackhmmer:B2J7U5	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 152 and 283 amino acids in length.	24.00	24.00	24.00	24.00	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.45	0.70	-5.47	17	81	2012-10-10 13:59:34	2011-11-14 11:54:57	1	2	76	2	32	109	79	171.00	22	81.08	NEW	-llhus-lcWshLNPhRG-tuPuAupLWGDRsssssoGhLV+FpcGFpSPPHIHNloYRGlVIpGtlHNDD.cAtphWhPsGSFWTQPAG....EsHlTAAcuspslhYlEIssGPYLV+PsppsFDsGERPlNlcpsNlVWLsspclsWlpss.......usphsaLWssssstthpGhhl+LPsuFpGplpopussh+AVllpGplsap..p.spspsLtsGSYhsustc..Hpl..ps-pssslYlRosGcaplp	..................................................usthusLaGD.tppushshhl+hssGapssPHhHshs.p.h.hVIpG...t...h......h...s.....s...c....s.t.......hssGuaah.PuG....t.Hhshspst.p.h....h.htpsPh...............................................................................................................................................................h.............................................	0	9	18	26
+14351	PF14500	MMS19_N		Dos2-interacting transcription regulator of RNA-Pol-II	Wood V, Coggill P	pcc	PF12460	Domain	This domain, along with the C-terminal part, Pfam:PF12460 [1], is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2].	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.65	0.70	-5.13	55	354	2011-11-14 16:18:51	2011-11-14 16:18:51	1	16	268	0	250	358	4	225.50	28	24.04	NEW	VpsLGphLTsp-sthRs+ulp.hLosVLppLs.ssh..LscpplplLhsFYps.......Rl..cDptslhss.LpGltuLs.phpp.......hstst...stpllculhpchps..puhhpssRhtsapllpslhppatctL......pshus-Flh.GhlphhsGEKDPRNLllsFplhp.hlhppa.s.............l.spasE-LF-lhhCYFPIsFpPPsNDP.h.sITp-DLptsLcsslsuoshFAphshPhLlEKLsSos.s..sKhDoLpsLttChpsa...sss.slppahhslWsuLKhElhps	................................ht..lts...p..hRt+.uhp.hLstll.th...ph.............Lpppp.....l.thLhtFat.s.......+l..p.Dtth.l..s..hpul.......ttL....h.tt................................hs.s.......s.plh.p.sl..h.p......phps....ps........h.t...t.p...Rhtsapllp.th..h.pp..hp..t.tl......................pths.s..p..ahh..shlp.hhsGE+DPRNLhlhFplhp....hlhppas........................................h..sthsE-lF-sh.sYFPIsFpPss...s.Ds..h...sIotc-Lt.sLptsls.usshF.A......hshPhLl-Kls...Ss.....s......sK..h.....DsLpsL...t..Ch...t....Y...s.....p..pl.ttah.plWsul+hElh..s..........................................................	0	84	137	208
+14352	PF14501	HATPase_c_5		GHKL domain	Bateman A	agb	Jackhmmer:B5CQB8	Domain	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.36	0.72	-4.30	80	2619	2012-10-11 19:05:54	2011-11-14 17:49:38	1	17	1244	0	315	12868	2588	102.70	24	25.87	NEW	l.pshDlsslhuNlLDNAIEA....spc.........h..p..p...c..+h.Iplpht.t.pp..sh..lhIplc.N.s.....hss.....................ph......sp.....hh......oo..K.p.c.tphH.GhGlpSlcphlcKY.sG.slp..hp.hcss..hFphplhls	..........................................h.p.hDls.pll.u.llDNAI.E..u......u.tc.......................h..p.............pth....l...p...l..s..h.h.....p....p....p.......sp.........h......h.........h.......h.....l.p...Ns........hpp.............................sh..........sc...........lh..........sh....p....s......c.....s..p.....s+....G..l..G..L..p.sl...cc...l.l.c.....p...a...ss.....l..p....h..p....h...p...s..s.....h.F.p...plhl...........................................	0	158	232	280
+14353	PF14502	HTH_41		Helix-turn-helix domain	Eberhardt R	re3	Jackhmmer:D2A9I0	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-7.96	0.72	-4.34	19	338	2012-10-04 14:01:12	2011-11-15 11:51:03	1	2	335	0	28	586	65	47.90	75	16.35	NEW	psG-RlpTIsEhucchsluhGslQsALKhLcspsAlpL-pRG+.GTal	...........KCGNRLKTIDELATECRSSVGLTQAALKTLESSGA.IRIER.RGRN.G.SYL...........	0	8	14	23
+14354	PF14503	YhfZ_C		YhfZ C-terminal domain	Eberhardt R	re3	Jackhmmer:D2A9I0	Family	This domain is often found in association with the helix-turn-helix domain HTH_41 (Pfam:PF14502). It includes YhfZ proteins from Escherichia coli and Shigella flexneri.	27.80	27.80	27.90	49.80	26.90	27.70	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.42	0.70	-5.02	20	369	2011-11-15 11:54:42	2011-11-15 11:54:42	1	2	339	2	28	144	1	210.60	73	75.69	NEW	chphLLphAslsslVssMPLPYS++YEGLATGLpppFcp..slPh...hAaMRGustRlcsLpsGhYDaAllS+LAAcpalcp...cslclshphGs.poYVupHhlla+csppppI....hRlGlDssShDQplLTchhhc.scclEhVElsYsphlptlhpGpIDAslWNh-..chchps.hslphhslpp...pp..hhpcsocAVlllcp-spslppllpphVstcpllphQpcVlpschhPsY	...DNKALLoHVDINNVVCAMPLPYTRLYEGLASGLKAQFD...GIPFYYAHMRGADIRVECLLNG..VYDMAVVSRLAAESYLTQ...KGLCLALELGP.HTYVGEHQLIC.RKG...ESANV.....KRVGLDNRSADQKIMTDVFFG....s.S.DVERVDLSYHESLQRIVKGDVDAVIWNVV.AENELT.....M..LGLEA..TPLTD...DP.RFLQATEAVVLTRsDDYPMQQLLRAVVDKHALLAHQQRVVSGEQEPSY.........	0	8	14	23
+14355	PF14504	CAP_assoc_N		CAP-associated N-terminal	Coggill P	pcc	JCSG:target_417453-SP18049A	Domain	The function of this domain is unknown, but it is found towards the N-terminus of bacterial proteins carrying the CAP domain, Pfam:PF00188. All members that do not otherwise carry an additional Cu_amine_oxidN1, Pfam:PF07833, domain are likely to be extracellular as they start with a signal-peptide. Most other non-bacterial proteins with the CAP domain are allergenic [1].	24.30	24.30	24.40	25.00	23.90	23.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.76	0.71	-4.46	63	757	2011-11-15 12:29:15	2011-11-15 12:29:15	1	5	529	0	63	374	0	139.40	32	41.03	NEW	IGpstpplppphG.pPpRhpsspYGacWalYpppstp.Yl.luh.pc..s+VsulYssuspls..hsshclGpstpplhcphshpPphslptssppYphchscc-h.hcslhph.sshY.splahDpa.ssplsul+hlsccshhchpsYt	...................lGpshcslpppaG.pPc...Rlhssta.GachYsYppcspp.YhhVuh.tc..c+VsulYsssptls..luPlKlspppuclh.p.+hulpPEhshphspppYchEh.-c-h.hpsll+h.sclYAplaaDpp..ssplhuVphlscphhsclcPY..................................	0	21	43	57
+14356	PF14505	DUF4438		Domain of unknown function (DUF4438)	Eberhardt R	re3	Jackhmmer:D2C4U6	Family	\N	27.00	27.00	319.50	319.20	21.60	17.70	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.62	0.70	-5.61	31	62	2011-11-15 14:52:22	2011-11-15 14:52:22	1	1	58	35	28	65	22	259.40	51	88.24	NEW	sYcVst-GpshlLPusGGITYNVplGDsshGhsGDHlEPGVSh....+s...sscp......NsuLphhuClGNpAcVlSG-AKGtpGhVTG+HGGl.-HVlVpFscEshEKLslsDpIhI+AhGQGL+LhDaP-lplhNlDPcLLc+hsIcp..ccGtLcVPVsshlPAhlMGSGlGussshpGDYDIhTsDpcssccaGlccLRFGDlVAlhDpDNcaG.RtYpcGAloIGVVVHSDChpuGHGPGlTslMTutsutIcPhlDspANIAshL	....YcVst-GpshllPusGGIoYNlplGDsshGhsGDHlEPGVSh.......+s.......sscp.NsuL.hhuCIGNpApVlSG-AKGtpGhVTG+HGGl.-HVlVpFsc-shEKlslsD+IhI+AhGQGL+LhDaP-lplhNlDPpLL-+hsIpE..ccGtLcVPVsshVPAalMGSGlGuusshpGDYDIMTsDtcssccaGlccLRFGDlVAltDpDNpaG.+tY++GAloIGlVVHSDChpAGHGPGVTslMTutsutIcPhlDspANIAshL..	0	8	16	25
+14357	PF14506	CppA_N		CppA N-terminal	Eberhardt R	re3	Jackhmmer:E0TM64	Family	This is the N-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity [1,2]. It is often found associated with Pfam:PF14507.	25.00	25.00	25.00	25.20	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.50	0.71	-4.45	12	394	2012-10-02 15:00:03	2011-11-16 09:00:13	1	2	368	4	25	213	1	117.00	61	50.78	NEW	hhsPVL+VNNRclN.sFYppoLGhKhL.EEsAhh.hus.t.ptt-+hllEESPShRTRtV-GsKKLscllIKsssPpEIEtLLApGsp.hcpLFKGppGYAFEslSPEsDhhLlHAEDDlppLp.lt-	.........p.IlPsLKsNNRcLNpsFYhcTLGMKsLLEEuAFlS..LGD.Q.oGhEKLVLE.EuPSMRTR......+VEGhKKLu+llVKVpNP.hEIEulLu+s...c.u...l.....c+LYK....Gp....NGYAFElh.SPEsDLlLlHAE..DDhssLhclt.c.......................................................	0	2	7	15
+14358	PF14507	CppA_C		CppA C-terminal	Eberhardt R	re3	Jackhmmer:E0TM64	Family	This is the C-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity [1,2]. It is often found associated with Pfam:PF14506.	25.00	25.00	28.40	25.60	22.10	24.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.43	0.72	-3.83	13	384	2011-11-16 09:02:29	2011-11-16 09:02:29	1	4	382	4	26	177	0	99.50	49	40.97	NEW	LSpFpl-slsLNVPs..c.ucuFYcs...splshsl-FppupGsDLslssslTWDLEhLEapVs.-aDlsuL+sphEs..pps..YlDK+cKlLVhoDsSpIElWFp	.............................................LSpFEI.ShELplPs..c.hcuFL-s............................scl.............s........soLcFl.AQGpDLsVDNslTWDLoMLKFhVs.-hDlAuLRp+FEu..p-a..FIPKS-KFhLscDpsNlELWFE..	0	2	8	16
+14359	PF14508	GH97_N		Glycosyl-hydrolase 97 N-terminal	Coggill P	pcc	PF10566-seed	Domain	This N-terminal domain of glycosyl-hydrolase-97 [1]contributes part of the active site pocket. It is also important for contact with the catalytic and C-terminal domains of the whole [2,3].	25.00	25.00	29.50	29.50	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.95	0.70	-5.41	243	798	2011-11-16 12:22:34	2011-11-16 12:22:34	1	17	279	12	179	796	147	258.40	27	38.27	NEW	lsSPDGplplsl.......shs.s............p.sYslpa.....puctllpsStLGlphptss........................hspshp.lhssppssh.ccsap.sh.GcppplcscaNElslshp.ptts..............t.htlpFRlasDGlAFRY.p..hstp.tsht.......hhl.sEtTpFsh..ssstpuah.....hs.t.t................hs.........saEt.Yppsslsph............pt.............................hsphPlhhcst..s.s..halslpEAsLhs.YsuhtLp.ss......ts.shpuths.ssts....................t.tsh.h..........psshsoPWRslhlucssssllp.osllhsLs.-P	............lpSPDGplplsh......slsts............pssYplsa........cscsllpsStLGlphpsss.............................h.spshp..lpssp.ps.s..D-sap.sh.Gcpppl+scYNElslshppsts..............tth.lpFRlasDGluFRYp......hPpp..tsht.......hhlpcEtTpFsh..s.sst..p..uahhs.s..s...................ap.................saEt.Yppst.l.sch.........pt.............................hsphPlh.hcss...c..G...halslpEAuLh...s..Ys..uhpLp.ss......pstshpuths.ssts............................s.tsh.h......psshsoPWRslhluccstsllp..oslhhsLscP............	1	71	152	171
+14360	PF14509	GH97_C		Glycosyl-hydrolase 97 C-terminal, oligomerisation	Coggill P	pcc	PF10566-seed	Domain	Glycosyl-hydrolase-97 is made up of three tightly linked and highly conserved globular domains.  The C-terminal domain is found to be necessary for oligomerisation of the whole molecule in order to create the active-site pocket and the Ca++-binding site.	25.00	25.00	40.20	38.70	20.50	24.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.13	0.72	-3.92	195	791	2011-11-16 12:46:07	2011-11-16 12:46:07	1	17	276	12	177	794	106	99.50	33	14.68	NEW	ssWD-TchLpuc.sG-YlslAR+s.......ss.sWalGuhospsuRs..lplsLs.FLs.pG..tp.YpAplYpDG.sAsh......sspsa...plpp...ppV.sspspL.plphAsGGGhAlplh..	....ssWD-o+hLcuc.sG-......YlslAR+p...........us.sWalGulss..p..psRs..lplsLs...FLs..tG..............pYpA....plYpDutsAph.......sspsh...........phcp............tpV..ssp.spL..plphusuGGhAlplh.............................	0	71	153	169
+14361	PF14510	ABC_trans_N		ABC-transporter extracellular N-terminal	Coggill P	pcc	Pfam-B_101 (release 25.0)	Domain	This domain is found at the N-terminus of ABC-transporter proteins from fungi, plants to higher eukaryotes. It would appear to be an extracellular domain.	25.40	25.40	25.60	25.50	25.30	25.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.63	0.72	-3.89	317	1186	2011-11-16 17:21:30	2011-11-16 17:21:30	1	43	200	0	805	1238	0	101.70	20	7.47	NEW	Lspphsp......................................................t..............D.....s..pL..s.........spsc............s.F-.scpal+plhchhspsuhp.h....phGV.sFcsLsVpG.u..suschtsTl.sNhhhs	.........................................................................................................................................................................................D.....tpL..s...........spsc.......................................p.ac.s.cpal.c..p..h...t...c.t...h.c..p..s......Ghph.....plGV.tacsLsVpG.u..sssp.h.sTl.hNhhh...........	0	147	445	691
+14362	PF14511	RE_EcoO109I		Type II restriction endonuclease EcoO109I	Coggill P, Eberhardt R	pcc	pdb_1wtd-Jackhmmer:Q9RPJ3	Family	This is a family of Type II restriction endonucleases.	22.50	22.50	22.90	23.20	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.10	0.71	-4.91	22	53	2012-10-11 20:44:47	2011-11-17 13:56:36	1	2	52	4	15	47	3	194.80	28	76.72	NEW	pl.ppscpalcppIsphHp+phppL.ppLcLhclLc.KNPaLF+.spslLous-llcullcAa.....LuSs-EThFGs.alEsLAhalsptshts.p......SshpGIDlEF.....ppDup+hhlslKSGPNhhNusplpphpscF+pstphlRos.t.shphsslsGssYGccpp.sps....................cYhchsGQcFWphlo.G-cshYhclI-slGctAcEps	..................................................t....thpphht..I...p.+thp.h.pphp..pl....NPaLac.hpsl.sup-hsculhcAh.....luouc-TsFGs.hhppLhhhlspssh.................................SshsuhDlEh.....ppDGphhllplKSGsNshNpspl....pplp....pcF+phtsphR.....shs.psl.sGlsYGcssp.sst.p.h...........................t.cYhhlsGpcFWpalo.G-cshYtclhcsls.hApEhs.............	0	5	11	14
+14363	PF14512	TM1586_NiRdase		Putative TM nitroreductase	Coggill P	pcc	Jackhmmer:Q9X1S2_pdb:1vkw	Family	Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.35	0.70	-5.14	5	84	2012-10-02 14:48:17	2011-11-17 16:31:20	1	1	81	1	19	82	2	203.90	23	84.37	NEW	MNIFEAIENRHSVRDFLERKMPERVKDDIENLLVKFITKKLDWKINLSSFPSYIYAKAEKHFDELVEYGFQGEQIVLFLTAQGFGTCWMARSPHPDVPYIIVFGYPRTRNFTRKRRPITSFLENDLEELPPEIVKIVEMTILAPSALNRQPWKIKYTGGELCISSERPVDLGIALSHAYLTAREIFKREPVIQKREEDTYCLILNP	.......................................................................phh-hh..R+SVRpa......pctl........s......pp.......l......h.....p......pl...........p..........s..........l...................h....p....h............l.......h...c.p.......h.....t....h..p....h....p....h................s...............p..........h......sp...Y.....l...........s.hh...ucc.pt.........s...h...h.p.............p.hGYhuEplVLhhpslGLuTCW...l.........u........h........s.....................p.....t...........c.............l.........s.......h..l..I..s..hGa...s........p.s..p....sh......s..c.....+..........p..+.sh.......pp..h.hp...t.............h....p-..hs..p.......h..h..p.hlcushLAPoAhNpQ.a.......h..h.........h.p.s.s..pl...........h.........h..............................................................................................hthttt............................................	0	13	19	19
+14364	PF14513	DAG_kinase_N		Diacylglycerol kinase N-terminus	Eberhardt R	re3	Jackhmmer:P23743	Family	This domain is found at the N-terminus of diacylglycerol kinases.	23.00	23.00	23.00	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.00	0.71	-3.97	9	283	2011-11-18 15:00:42	2011-11-18 15:00:42	1	30	72	2	119	251	0	118.70	37	20.79	NEW	tpccWspLSPpEFsQLQKYsEYSTKKlKDVLcEFptsGshspYsPc-.......sIsaEGFchFMKsYLEs-.lPccLspHLFhSFps+.pp..................................ss.sscSKst.hpush+.................p.ssVlpLKDlVCYLSLLEsGR	................................................ph..loPt-FtQLQcY....-..Y.S.oK.KlpDVLptF......t..s..G...h....t....pY...tt...................sIsa-GFchFh+saLEs-.lPpchst+LFhSFppp....p............................................................................................................................s.t.....t...tp..................t..........................................h..l.LpDlsCYhSLLEtGp....................................................................	0	22	32	67
+14365	PF14514	TetR_C_9		Transcriptional regulator, TetR, C-terminal	Coggill P	pcc	pdb_2qtq	Domain	This family comprises proteins that belong to the TetR family of transcriptional regulators. This family features the C-terminal region of these sequences, which does not include the N-terminal helix-turn-helix.	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.63	0.71	-4.33	4	174	2012-10-03 00:15:22	2011-11-21 15:07:58	1	2	158	5	45	121	5	127.00	28	58.91	NEW	DMSPpAKLRRHlutsIcTYacYPYLpRLLhtLhRDusEtpARcIAcpYlpPLtcAYpRhIptGVtsGsFRPlDPQLFYFsVhGAsDphFSuRhVL+asaG.DplsEpLRcpYpEpsl-hIMuGlLA..tc	.......................................................s.....tthphhlptl.hctYh....ch....P.h.RLl...p.s....hpp...st..tt....t...p.ppl.....lcp.....hlt..P.lscslp.sll.EcGlctGlhR.p.lDP.hhalolhuLshah.a...sp.sLttla.Gh-..hup.phhcphlctshpLlhtGh......th...........................	0	12	24	34
+14366	PF14515	HOASN		Haem-oxygenase-associated N-terminal helices	Coggill P	pcc	Jackhmmer:Q9HY91, pdb_3bjdA	Domain	This domain represents a pair of alpha helices, which are found at the N-terminus of some Haem-oxygenase globular domain.	25.00	25.00	123.70	121.40	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.01	0.72	-3.61	2	32	2011-11-21 16:17:14	2011-11-21 16:17:14	1	2	16	3	2	30	0	86.30	68	26.25	NEW	hopRshS..th.....stutllA-ALtsuAohcQIp.AhpAlhAlTtKuLtGDtpAYAtYQtLLh.LplusDs.Tt.TRRWhAstlYhVE-RF	.hspRshS.Pth.....ptutllA-ALtstAo.cQIs.AhptlhAlsttGLtGDtpAYAtYQtLLh.LplusDstTt.TRRWhAptlYhVE-RF	0	2	2	2
+14367	PF14516	AAA_35		AAA-like domain	Bateman A	agb	Jackhmmer:A0YLR5	Family	This family of proteins are part of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.97	0.70	-5.80	99	465	2012-10-05 12:31:09	2011-11-22 16:51:27	1	74	91	0	172	633	10	318.70	25	46.18	NEW	hPpGsls.LsSsFYlERs.....PlEppsYppIhpP.Gu...LIRIKAP+pMGKTSLlsRlLspAppp....uYpoV.LshppADpsl.hssL-+....FLRWFCsslo+pLpLt.....s..pL.....--YWD..-thG..SKhsC.otYFccYLLppl........s.pPLVLuLDEVDclFpaPclApDFhsLLRuWHE.cu+....ppplWpKLRLllVHS..TElYls.LslNQSPF.NVGLsIcLscFohpQVp-LApRasLs.hstsp.....lppLMshVGGHPYLl+LALYalsp..............p...plT........LcpLLppAsTps..G.IYscHL+cphhpL.pppP....-LspAhppVlp.us.pslpL..-shtuaKLcShGLVphp..GsplhspCp.LYRpYFpc	..............................................................................h...s.l..ss...Yl.R..........h-p.hhptl.....hp..Gp...h.hhlhssRQMGKoS.L....h.hch...h.....pphp.p.p..............s.hts...s..h....ls.hp.t...h..s...s....t............hs.s...hpp.............ah.p..hh...s..tpl...sp..p...l..p..L................................t......pl.......p..ph...W.p....c..p..hs.........sh...ph.....sp........ahp..p..h..l..Lt...ph...............s..ps...l....V.lhlD....E....l..D...p...l...h....ph......s.....h..h.......p.-F...h...shlRthap....ppt.......p.ps.a.p+.Lphsl....ht....s.......Tp.s......l......h.....hc........h.......s......p......oP......F.....Nl..G.h..s.lc....Ls..sF....sh.pp....l....p.s....L....h....p....t....h....t....h.p.....hspsp......lpplh.t.hs....uG..p.P.aLspth.hhhl.sp..........................................................p....phs................lpp.l.l.pp....t.h.h...ps.......t.......s.....p...HL....cp.h......h..ppL.....p.p...............cLht....hhp......pllp.........t.....t.....p..............h..t.h..........p.....s.......t.t..h..pL....h.GLlhhp...ts.tlh.ts..lYpthFt........................................................................................................	0	31	126	171
+14368	PF14517	Tachylectin		Tachylectin	Eberhardt R	re3	Jackhmmer:Q27084	Family	This family of lectins binds N-acetylglucosamine and N-acetylgalactosamine and may be involved in innate immunity [1-3]. It has a five-bladed beta-propeller structure with five carbohydrate-binding sites, one per beta sheet [2].	25.50	25.50	25.50	25.70	25.30	25.20	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.88	0.70	-5.03	8	90	2011-11-23 07:54:36	2011-11-23 07:54:36	1	9	23	1	14	107	1	124.10	40	56.07	NEW	auVspDhclptGssPcstsDsa...hsRAsplG+..hsshchlhhuPsGcLYuVcuu...pLYpG.pshsosuspWh.upu++IGcGuWspF+......FlhFDPsGlLYAVotsGpL..YRussPss-spsWhttpAshIGspGWssF-sLFFcPpGhLYuVs.scs..cLhKph.PPsussDcWLu.uoollupuuW.cs.s+FluFossGsLauV.cssGtl..Y..RstsPppssssYhccAphlGs.uaspa+h	.....................................................................................................lYulp.ss....hYpt.....pps..ssph....h.tss.....thIGpu.WttFp......hlhh.ssG.LY..GVss.s..pF..Y+RsP..PTHuSDNWL..G..SAchIGoGGW+s...FphLh.................................................................................................................s............................	0	6	9	14
+14369	PF14518	Haem_oxygenas_2		Iron-containing redox enzyme	Coggill P	pcc	Pfam-B_412 (release 26.0)	Family	The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase [1].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.40	0.72	-3.87	140	559	2012-10-02 21:56:19	2011-11-23 09:10:08	1	8	409	3	220	662	254	104.50	24	27.19	NEW	Lhp.....shhD.Eh.G.sGp.scp.h................HspLa.......tchhpshGlsss.h.........shhct..hs.s.....t.....sl.u.....hsNhh..hhuh.p.+.p.hh.sthlGths.s.hE....hsss..h....hpphsp....u.lc.R.h.G...h.stts...hpaas.Hlp	.....................hhpshh-.E.h.G.....sGp..pp.s.................HspLa.......tcllpshGls.s.h..............................thhpt.hs..s..........t........sh..t..........hs.shhh.hhsh.p.c.phh.sthlGhhh.uhE....hhss.t...hp.phsp....sLc.c...h.G.....h.s..t...htaashHlp...............................	0	52	127	189
+14370	PF14519	Macro_2		Macro-like domain	Coggill P	pcc	Jachmmer_A6ZME4, pdb_1njr	Domain	This domain is an ADP-ribose binding module.  It is found in a number of yeast proteins.	27.00	27.00	27.00	27.00	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.93	0.70	-5.29	3	54	2012-10-02 00:07:53	2011-11-23 11:38:38	1	1	53	3	34	65	2	231.40	30	93.76	NEW	MTts.s++p.hN...phRIVLCDTNEVVssLW+KhlPKuLlpssKhVClHHGsLESLhcSMRKscspH..........sGcKYAIVSPGNSFGYLGGGFDLALaNYFGGKPFETWFRscLGNRYHTVGSATVIDLpRChLsch.EsRDGIRYIIHVPTVVAPS+PIFpcupPLKTGYEPVFNAMWNSLMHuP+DlDGLIIPGLCTGYAGVPP-ISCKSMAFALoLYMLsD+ISKEL+NlLIMYYLGYPFEPFFLESCpEECQtLGIDIEpLcSFNVE+DsI-tLIP++lLs..L	................................................................................................................hp...h................................spsh...uIVSPuNSaGahGGGFDhAlh.......p.........h.F..G.....s.....+....s..h...E......s...hhR..ppl..s......sc........Y.......t....s...l...GS.sTl..lcLt.......cth.t.p.............tptp.......sl+YllcsPThlsP...pts......has.p...tshps.shp.l.....Fs.s.hW...N....sl......h.........p.s....s.p.c.I-sLllPGLsTGauGVss.lus+pMsFAlpLah...h...t..........................................................................th..................................................................	0	6	17	29
+14371	PF14520	HHH_5		Helix-hairpin-helix domain	Bateman A	agb	Jackhmmer:C6UUJ1	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.79	0.72	-3.80	554	12686	2012-10-03 02:11:09	2011-11-23 13:36:33	1	143	4845	77	3277	11596	4688	61.00	23	15.86	NEW	p..th..............h..p...t....L..h.......s...l.........sG........lG......s.p......hu.tt...l.............hpt..........ht...............................................o...l..p....p.l....t.p..............s......s.....h..c.p.........................................Lt....p....l....................G...............................l....u..p.c...pAppl...l.tph+.c	.............................................................................h....ppl..h......s......l.....sG........lG..sc......hs.tt...L...........................hsp........t..ht...............................................o....h..p....c.l....t.p......................h......s.....h..c..c...................................................Lh....p.....l...................................tG..................................l.....u..cc...sAppl...l..thc...........................................................................................................................................	0	1019	2066	2740
+14372	PF14521	Aspzincin_M35		Lysine-specific metallo-endopeptidase 	Coggill P	pcc	Pfam-B_2237 (release 26.0), pdb_1g12 	Domain	This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS:M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054, His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner [4].	30.00	30.00	30.10	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.18	0.71	-3.69	34	226	2012-10-03 04:41:15	2011-11-23 14:29:17	1	8	116	9	119	217	3	142.80	27	48.57	NEW	u.Lpptsss..pp....apsWFGshssp...........+hsslhsphsshstsh.s..s..hthsCs......sst..s...sshthshPsph.tp..IhlsssFhs.hss.....sGhDSpsuTLlHEhSHFss.........shGTsDh..............sYs..pssupsLupssPspAlpNADshEhas-	..........................................................s..........t.p.....appWFGshssp...........+hspspst.hhphcpshts.tt..h...hhsss.........sp...s.......sthAhshssph.hp.....lal.ss.t.....Fhp.sss............oGp...-.S......+....suTLlHEhSHh.s...................ss..t..opDh..............sYu..ppssp.p....LApspP.spAlpNADsaphah..................	0	87	97	113
+14373	PF14522	Cytochrome_C7		Cytochrome c7	Eberhardt R	re3	Jackhmmer:Q74BP5	Family	This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated. In c7-type the last haem is His-Met co-ordinated [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.26	0.72	-11.57	0.72	-4.34	198	1003	2012-10-01 23:37:15	2011-11-23 15:49:51	1	52	372	25	549	1372	400	72.40	23	23.15	NEW	shFsH.......ptHhp........th.....s..........Cs..sCH.sp................hh....sspt.....hshsph.......t..s............ptCss.CH..............sup.....pu..........................sssCs.pCHt	.................................FsHphHht............th..s..................Cp..sCHss.............................ht.....ttph....................hphssh...t..s..........ttChs.CH..................................stp............s......................hssssCs.pCH................................................	0	172	394	505
+14374	PF14523	Syntaxin_2		Syntaxin-like protein	Bateman A	agb	Jackhmmer:E7Q9M8.1	Domain	This domain includes syntaxin-like domains including from the Vam3p protein [1].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.27	0.72	-3.99	91	588	2012-10-03 05:55:03	2011-11-24 17:46:35	1	10	286	1	374	673	2	97.20	24	35.43	NEW	luspl...hplsss....lsplp+hhpplG.Tt.....+Ds.clRcpl.c...........phhppssphhcphsptlpplsph.......................t.....pppphtppKLsp-FppslppapphQcp.htp+ppsts	....................................ustl.plsps........ssplpch.lspLG..Tt..........pDoscLRcpl.p...........phpppss.pls+cssptl+phsph..............................t.pppp+hppp+Lsp-FpssLppFQtsQ+pss-+p+t..h............................	0	100	169	281
+14375	PF14524	Wzt_C		Wzt C-terminal domain	Bateman A	agb	Jackhmmer:A8A1Q5.1	Domain	This domain is found at the C-terminus of the Wzt protein [1]. The crystal structure of C-Wzt(O9a) reveals a beta sandwich with an immunoglobulin-like topology that contains the O-antigenic polysaccharide binding pocket. This domain is often associated with  the ABC-transporter domain.	22.00	22.00	22.00	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.65	0.71	-4.49	236	837	2011-11-25 13:44:43	2011-11-25 13:44:43	1	9	707	2	260	731	162	141.70	17	33.12	NEW	thts.sttphGsspApI..pssplhs.tpGp.ssh...lpsG-plplplp..hph...ppslps.sl..hGhhl.+..sppG..h.lhG.sNohhpp....ttls..hht..........upphplpaphph...Lss..G.pYhlssul...................t..ptp...stp.hchhpcs.hhF...pVh.s..................spphhGlht.lss	............................................th........tpttspltpsplhs...tpsp..hp.h...lps.G-p.lplclp..hps....pps.lpp..sh..hGhtl..+.......s.ppG.........thlhG..sNo.hhps.......hplshh...........ssphphphphth....Lts..G.pYhlslul..................pppsth.h.chh.pp..s..hhh..pVhs..........p..h.Ghh.h.....................................................	0	95	178	225
+14376	PF14525	AraC_binding_2		AraC-binding-like domain	Bateman A	agb	Jackhmmer:D9V2D0	Domain	This domain is related to the AraC ligand binding domain Pfam:PF02311.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.69	230	1819	2012-10-10 13:59:34	2011-11-25 14:10:04	1	6	746	0	600	1693	67	174.60	16	52.75	NEW	hcchluphhs...s......t..........clpst..s...ts..shp.....uphpthplGs..lslstlp......hs........sps......pl.....cs.sp............psh..hhlplslpGpuplp.ps.sp.pstsssup..sslhsssp.s.hp...h.p.hss.........ss.c.....plhlpls.............................c.......ph..ls.pshp.t...........sht.hs...sp.................hshs.sshu......thhtp.....hlptlhs.phsths.....s......hhpps.h..hspph...p.s.Llh.shLh	...........................................................phhsph.hs.s......h..........p..hps...s....tp...thp.....uphpt.ht.hss......lplspls........hs...............sth............tl.....ct..ss................sth..hhltl....l..sGps.t.h.p...p.s.....sp...ps.t.hs.sGc.....hslhcs..sp.s.hp...h.p..hpt................ss...c.....plsl..t.....lP.............................csh.Lp.phhs.t...........sh.h.hs...p.........................l...shs...sshs.......phhtp......h..lpplhp..phst.hs.............tt.t..t..htpth.....p.Llh..h..h......................................................................................................	0	118	310	451
+14377	PF14526	Cass2		Integron-associated effector binding protein	Punta M	mp13	CATH:3gk6A00	Domain	This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown [1] to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-11.05	0.71	-4.20	24	758	2012-10-02 11:08:51	2011-11-25 15:11:58	1	8	542	1	127	2424	50	145.20	18	79.49	NEW	clpchsuhslluhth..phppspt.....hptchsphapphh..p..pt....hsph.tpp...pchaulhts.t......psthshhsshssps......hsps.......hphhphPsupYhshps.p...uphs.p.lt.chatph.htth.ppp.psat........psss.s........p..hEhY........hpss................p....lElhIPV	...............................................................................................l.ph..thtlhuhtt.....hp.ptptt............tt.h.s..shapplh.....p.....ps...............hsp..l...t.t..........ssh.....a..u..l..a..p.......sh.t........hpsc.....h.s..h.........l.s.h..s..sps..........h...p.s....................hphh.p..l......s.s.c.Yhs.h.ss.p..........sphs..p..ls..p.....h..a...pth....hthh...p..p...ssht............hsss..s................s...hEhY............hpss........................s-lhlPl.......................................	0	51	88	110
+14378	PF14527	LAGLIDADG_WhiA		WhiA LAGLIDADG-like domain	Bateman A	agb	COG1481	Domain	This domain is found within the sporulation regulator WhiA.  It is a LAGLIDADG superfamily like domain [1-2].	23.20	5.00	23.20	5.00	23.10	4.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-10.04	0.72	-4.12	23	1981	2012-10-03 01:41:40	2011-11-28 15:47:47	1	15	1950	3	344	1568	111	93.00	42	29.70	NEW	tpualRGsFLuuGSlscP.pss.YHLElssssp-hspplpcllp..ca.slsuKlhcR+spallYLKcuEpIschLpllGAppuhhcaEslRlh+-hR	.................t.+uYLRGAFLA.sGSlssP....-po..YpLEIho...h.p..-aA.psLspl.hp.......pa.tL.......s.....A.......K.s.......l.......E.......R.....+.......p.......u..........hls..Y...L....+..-...u........E.c.Is-FLslIGAhpu.hl.c.F.EclRIhR-hR............................................................	0	139	249	304
+14379	PF14528	LAGLIDADG_3		LAGLIDADG-like domain	Bateman A	agb	Jackhmmer:P21505	Domain	This domain is part of the LAGLIDADG superfamily [1].	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.61	0.72	-3.74	233	970	2012-10-03 01:41:40	2011-11-28 17:32:55	1	236	486	19	348	1219	203	81.20	21	10.86	NEW	t.sFLpGl....asuDG..sl.....p..t..pp................tlplss...s.sp....p........llc........plpp.l.L.h.p.hGIhu..plh.......t............c.......................p...................p....................psh...a..pLhI....su..cs..ht.pFhcpIG	....................h.taLpGhasuDG...sl.....p..t..ppt..................plphs.s......s.sp.....p........lhc........slpp.l.L.h.p.h.Gltu...plh...................p...........................p.....................p.............................................................psh...a.plhl....su..cs..h..tahp.l......................................................................................	2	97	192	286
+14380	PF14529	Exo_endo_phos_2		Endonuclease-reverse transcriptase 	Coggill P	pcc	CATH:1wduB00 	Domain	This domain represents the endonuclease region of retrotransposons from a range of bacteria, archaea and eukaryotes.\	\	These are enzymes largely from class EC:2.7.7.49.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-11.03	0.71	-4.49	204	2004	2012-10-02 01:25:08	2011-11-29 14:09:45	1	110	233	3	1603	5329	1737	121.10	19	18.41	NEW	lhlhusYhsPst.............hpphhpplpphhpphs.......hllsG.DFNu..........tp.hWuu................ss..........................pcGptL....hphhpptslthh............sp.s..pt.sTahstps..............t....Shl.....Dlshs...ssshhtt..................h...hh.....SDHphlh	...................................................hlhslYt..Pstt................................pth.h.pt.L.pt.h.hpph.........thllsG.DF.Ns...........................................................h.p.....s.....t.....hss...................tp.........................tp...............................................ppu..p...tl..........hp.h..h.p...p...t...s.L.t.h............................................................pt..t.....pt..hTahsspt...................tstl.....Dhhhs.sp.shhtt........................thh.t......hh.....................SDHp.l.............................................................................	0	649	1047	1503
+14381	PF14530	DUF4439		Domain of unknown function (DUF4439)	Eberhardt R	re3	Jackhmmer:Q7TXQ6	Domain	This domain has a ferritin-like fold.	25.00	25.00	25.30	25.40	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.59	0.71	-3.67	37	325	2012-10-01 21:25:29	2011-11-29 14:31:28	1	1	321	2	85	267	7	124.60	31	52.61	NEW	ALpsALAAEHAAlYuYGlluu+l.ssstpstApsuhstHRARRDslhthlpstGssPssstAuYtLPh......sVsssusAspLAuplEpcsAssatsll.tsssushRshAspALp-uAlRus+Wpusss......AFPGhsp	..............h.tsls.hEauslauh..ul..s..t....u....h.......ss......t.hp............sttshttH+spR-pltptlpst....usTsss..s..s..s..G...Y..tl.sh............s..ssssAuutpLhstl.Es.csssuWtsVs..tAssu..ssRshAlsuhspsAhhhs+httshs.........saPG.............................	0	28	64	81
+14382	PF14531	Kinase-like		Kinase-like	Eberhardt R	re3	Jackhmmer:B6KSS4	Family	This family includes the pseudokinases ROP2 and ROP8 from Toxoplasma gondii (Swiss:Q06AK3 and Swiss:O15693). These proteins have a typical bilobed protein kinase fold, but lack catalytic actvity [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.70	0.70	-5.45	8	140	2012-10-02 22:05:25	2011-11-30 11:55:51	1	3	7	6	79	15114	247	263.20	26	50.30	NEW	shpVsSpLGptsRsLl+sshlshschulhapssDpETsEshsl+Vhhhss.-sopp-l-ph+cpsLAlsL.hhul+NPppApsahRhlhPaDLVplssKshhhptpscppshhVhNhFhLhPsspssL.........phlschltppssp..ctsLsptARLhLTlQhIRLsAsLQscGlVHuchpssshhLcpcGGlaLssF..ssLsRsGs+ssh.upss....puauPPEhpup+tt..at..sssphTauhDAWsLGlsIahIWCtcLPhshsssthu.-a.............hFspCp.shP-sV+hLltphLphspcsR	...........................................................................................................................................................................s...........h..l.hhht.lt..t..hhh.spc.tp.p...htlh......h.....h............t....p.........s....st....tt...hpp.........hp...c.t...htht....h.........p...s....s.........A....p...h.....hR...hlh.....P.....D....h.l....tl....t........ps.........p..ht......t..ps.....h...h..l.......s..h.h..h..L..h..P..t.....h.....p..s...s...h.............................................tt.h..h..p....l.ht...h...ss.........p.p.t..h...s.h..h...s..+...h...h...L...T....h.....Q....h.l...+.L.........l...A...p...L......p....s........p....G....l....V.H.u..........c..lpP..p......s.h..h......l........t......p.......c........G...........t..........l...h......L...u....D......F............u.p.......l...h....+....s....G.......s....p..h..s........upss................................s....a......s.....P.......P..E.......h...h..s...p.......................................................p........p....s.........t......h......T......a..........u.....h......D.....A....WtL.Gl...s..l...a.h.l......W....C....t.c....h....P.....h......s......h....s......s......s......t......h......s.........p.h......................................F..s.....t....C.....t.....s........h.....P........-..........V......c.....t......Ll....pphL..phs.ppR....................................................................................................	0	57	58	79
+14383	PF14532	Sigma54_activ_2		Sigma-54 interaction domain	Eberhardt R	re3	Jackhmmer:D1EI59	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.45	0.71	-4.12	21	695	2012-10-05 12:31:09	2011-11-30 16:25:51	1	32	602	10	154	18102	4682	141.20	25	30.88	NEW	LGsSsslp-lpcpLEtsu..ppssPlLLsGEsGSshEhlA+al+psssP....Wlp.schppls...c...hP........h-...lLpp....A....sGGhLals-lsphuKshQpulhhlLs+.........u-.+hsl...Rllssuupshsp.htsssh-scLhphLSshslplPsL	....................................................................................lGpSthh.p.p.hppp.l...p...p.h.A........p...s......s......h........s......V...hl.h.GEsGo.G+pp.l....A....+.....h.....l...H.....p...h........u.s.p................tpt...s...hh...h..h..phs.......s........s...........................................tp.........h.lpp.........................u...........pG.GT..Lh.lsc..l..ctL..s..c.p...t...Qp..pL.s.phLpp.................................tc...cp...sh...........R.l..l...us.s..s...t.sht...p.......h..t.t.sph.t..t-La.h.hhs..s.pl.hs.L....................................................................................................	0	50	105	137
+14384	PF14533	USP7_C2		Ubiquitin-specific protease C-terminal	Coggill P	pcc	Pfam-B_1954 (release 25.0)	Family	This C-terminal domain on many long ubiquitin-specific proteases has no known function.	29.40	29.40	29.40	29.40	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.44	0.70	-4.90	69	415	2011-12-01 14:48:45	2011-12-01 14:48:45	1	20	259	1	265	395	4	201.30	27	19.14	NEW	ptlaYElLs.hslsEL.Es++s...lKlhWlssshpc-.......p.hplhlsKsuTVpDllsclpc+hph.....s-ststclR..lh...Eh......tt.Khhchhs.p-psltsl...schh.t.............................hhhE...clPp-Ehpht.p..tt.....plltVhHFp+-ss......p.aGlPFhFhlppGEsFs-sKcRlpc+h..slss.KpFp.KhKFAl.lphsph..........pYlpD..cc..ll.shhhptc..........p..LG.LDH.scss+p	............................................hlaYphLs.hsls-h.-sp+s.............hKlhah........p.sshpc.............phplhlsKpusltDllpclppp.spl...........scpt...stclR..lh............-l.....hsp..Klhplht..tcph..lpsl....sct..p..............................................hhhE....clPp-c.hshs....t-..............................hllsVh...H..Fp+-st..........psaGhPFhhhl+p..uE..phtcs+cRlpp+h....tltp.cpFp.K..hKFAl.l..hsp...................pYlp-..st...l..h..p.p................p.hLG.L-H.sps............................................................	0	84	139	212
+14385	PF14534	DUF4440		Domain of unknown function (DUF4440)	Eberhardt R	re3	Jackhmmer:Q11v67	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.37	0.72	-3.83	216	1968	2012-10-03 02:27:24	2011-12-01 15:55:36	1	41	1054	19	759	4175	1032	109.10	15	69.00	NEW	lhphcp.p...hh.p.u.h.....s.p..sD.hs...th.tpl...h..s.......s.-.h..hhh.....sss........Gth..h..s.........+pp..hlpth.........tp.......sh...h.t..h..t.ph.....ph.ps.......hp.l..p......hh...ss...sA.hlt....sp.hp.h.......pt...pt..s.....s...t.h.t.......tphth.splW.p+.p....ss..pWpl	...........................................................................h.tth...p.u.h.....s...p.....s-..hp....sl..tsh.....h..s...............s..-..h.....hh.l.........sss................Gth..h...s...........ppp....hh.pth...............ps.........tt.....h..p...t...t.sh........ph..ps..........hp..l...p........hh.....sc......sA....l..lp....hp..hp..h............ph.......ts...s..................s.....t.h..t............hp.st.h.stlap+.p.....ss....tWth................................................................................	0	280	490	656
+14386	PF14535	AMP-binding_C_2		AMP-binding enzyme C-terminal domain	Eberhardt R	re3	Jackhmmer:A6L0Y5	Domain	This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.06	0.72	-3.94	244	1758	2012-10-03 01:00:17	2011-12-02 13:31:06	1	7	1084	15	662	1569	228	94.80	32	21.53	NEW	GVNlFPoQIEplLhph.stlu.scYplllsR.p..s..s..hDplplpVEhsp..t.h.s.c.ph.............tp......hpp......lpcclpcpl+sh.lGl...s...s...cVclVpPtolsR.....S.E.G...K..A+RVlDpR	.......GVNVFPoQIEcllhp..h..t.t.l.s....s..c..Y..plh.l...s+.c......s...p......hD.p..lplp.VEhpp..th..s...p.................tp........hpp......lpcpltccl+sh.lGl.s...s...c.....Vpl.lpss....olsR.....o.p.G.....K..ApRVhDhR............	0	235	477	589
+14387	PF14536	DUF4441		Domain of unknown function (DUF4441)	Coggill P	pcc	Pfam-B_1275 (release 25.0)	Family	This family is largely made up of uncharacterised proteins from the Ciliophora.  The function is not known.	22.40	22.40	22.50	22.40	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.73	0.71	-4.12	66	94	2011-12-02 16:40:58	2011-12-02 16:40:58	1	2	2	0	94	142	0	118.40	24	42.38	NEW	pNh.hKNI.l+uF...tpalh...............pppcp.....................................hlhphhpph.........tpp.p.......hpphp..Kphppahcppshs.N.p.....lppllpsppaspl.FpaaLpptsptWL.ppS+lpstppahhhIphlhpshpst..phlpplpha.K	................................................................................................pNhhKNI.lpuF....hpalh...............pppc.p...............................................hlhphhpph.........t...p.......hpphp..Kphpphhp.ppshs.Ntp......lppLlppppapph.FpaaLptpsptWL.ppSKlpspppahhhIphlhpshpst..phhs.lphhp...............	0	94	94	94
+14388	PF14537	Cytochrom_c3_2		Cytochrome c3	Eberhardt R	re3	Jackhmmer:Q8EDL6	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.81	0.72	-11.87	0.72	-3.64	85	1009	2012-10-01 23:37:15	2011-12-07 10:41:39	1	39	603	40	274	1023	144	93.50	36	38.08	NEW	hHtptu.hsCt.sCH.......s...sst..ttst....s.hpspp................ClsCHs...sh.p.....ph......sp.ptt......................s.Hs.......sH..........spls.CssCHps.Hp...........ts.........hC.s.s.CHs	..................................th....hslsCs.sCH.................u.....pss....spp...cp.......ulcssh......................................Ch..S..CHh..sp.p....h.......pc..s.............................................hhPH.c.........sH...s.........scls.Cs.uCHu.h..Hs....................................c.tt.....phCs.s.CHs.......................................	0	87	186	233
+14389	PF14538	Raptor_N		Raptor N-terminal CASPase like domain	Bateman A	agb	Jackhmmer:F5H7J5	Domain	This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure [1]. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.	27.00	27.00	27.00	34.30	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.82	0.71	-4.37	48	343	2012-10-03 02:24:44	2011-12-08 19:24:50	1	25	255	0	246	365	5	148.00	52	11.29	NEW	+hKTsslsLllCLNIGlDPPD....lhKssPsA+hE....CW.....lDPps....hs..........t..KulcsI.upsLppQYcph..p.+.....s+a+.tlDPol--l++hCtshR+sA+s...-RlLFHYNGH..GVP+.PTssG.....EIWlFN+saTQYIPlslh-LpsWlssPslaVaDCSsAGhllpsFp	......................................................hKTsosALslCLNlGVDPPD....llKssPsA.+lE....sW.........lDPhs....hss.............p..KAlEpI.GpsLQpQYEph...p.R...............sRYKptLDPoV--lK+hCtoLRRsAKc....ERVLFHYNGH..GVP+.PTssG.....EIWVFNK.......sY..........T.......QYIPlSlYDLQoWluuPoIaVaDCSsAG.IlpsFp.......................................................	0	98	147	214
+14390	PF14539	DUF4442		Domain of unknown function (DUF4442)	Eberhardt R	re3	Jackhmmer:Q9I2R0	Domain	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 139 and 165 amino acids in length.  There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.48	0.71	-4.17	66	935	2012-10-02 20:54:35	2011-12-09 10:57:25	1	2	624	4	278	1704	374	137.40	21	84.79	NEW	GptlFStshsh+APYFuT.lpPplpcLcPs..hsplpl.c++tVpNHIGTlHAIAhCNhAEhAhGhhsEAolPs...stRWIPKGMsVpYlAK.AposlpAsAphs.s..........sa............pp.....s..s.-...lsVsVplh...D.psG.hp.V.spupIsh.WV	.....................................................h......hhht.hhP.h.h...hs.sshcl..hplsss.....pscl.pl..hp..h.ts.c.N.a...l...s..o.....h..auGulh.shs-.s....s.hG..h...h....h..h...t....plsp.............chh...h..h...s...K..u..hplc..a...l.+.........u..c...u..s...l.p.Ap.spls.p..........tph............tp.....p...tt...h.h.......l...p....lh....-..pp.G...ph...l..spsphph.h.............................................................................	0	97	182	244
+14391	PF14540	NTF-like		Nucleotidyltransferase-like	Coggill P	pcc	CATH:3c18A01	Domain	Structural comparisons with PDB:1kny indicate that this N-terminal domain resembles a nucleotidyltransferase fold.	27.00	27.00	38.40	37.70	22.10	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.33	0.71	-10.24	0.71	-4.50	23	78	2011-12-09 13:30:00	2011-12-09 13:30:00	1	1	78	3	27	80	0	118.80	40	40.16	NEW	MEslLRPIYQE+ASpssTLGllhlE++..pppsslTDsFDslLLVIscc.sEpshalKHYphssc+suL+lVs-cpLpcWllhGoNR+llDWlhpG+llFDRNEYlppL+pcLppFP.ppRc	.............M-slLRPIYQE+AScssTLullhIE+c..ppp..uulTDsFDslLLVIVcp.s-pshalKHYphcpc+AuLahVo-ppLpEWlLlGosR+lIDWllpG+llFDRNEYlppL+pcLppFPhtpRc.....	0	7	18	21
+14392	PF14541	TAXi_C		Xylanase inhibitor C-terminal	Coggill P	pcc	CATH:1t6eX02	Domain	The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylasnase.  Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.92	0.71	-4.69	112	1552	2012-10-02 15:32:34	2011-12-09 14:54:42	1	19	111	13	878	2503	14	147.00	24	35.70	NEW	tYalsl.puIpls.....sppl.s.lss.shh.........u...tGGshlsosssaThLtsslYpsltpAFsp.thst........h.p.ssssssFchCassss.h........tt..hshslP.sl.sLhhpu.....us.....phpl.us.shhlp.s..s...s.s.........sh.CLuFlss.................sstssslIGuhQhpsphl.FDltssplGFss	...................................................................Yhlsl.pu..IpVu.................sphl..s....l..ss...shh...............s..........suG..sllDS.GTs.hThLs....sss.Ypslppsh.tp...t..hst......................ss.s..h...s.s..h....c..h.C...ashss.........................ttstlP.s.....l.slpFps...........Gu.......shpl.s.s.p..sh..hh.t..s..s......s.s...........................hh..C.L...u.hsss...................................ttshsllG...sh...pQpshh.lhaD..ltpp.plGFt.....................................	0	106	490	698
+14393	PF14542	Acetyltransf_CG		GCN5-related N-acetyl-transferase	Coggill P	pcc	CATH:1xmtA00	Domain	This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterised by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site.  It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.46	0.72	-4.09	355	2309	2012-10-02 22:59:21	2011-12-09 16:30:00	1	16	1990	7	555	1626	130	78.60	29	78.76	NEW	Ratlth.s............t...uhh...sY..................pt...............sst.........hh.slsHThVssshcGpGlAspLlctulctsRppGh.+llPhCsalt.s.ah..c++P.-.a.p-l	..................................pa.lts-......Gpth..u.l...s.Y.............pp....................sss......hhhlsH.T.hVscshcGpGlupp.Llct.sl-psRc.p.s.....h.Kl...l..PhCsasp.phh..c+ps..-..a.p-l.................	0	176	360	478
+14394	PF14543	TAXi_N		Xylanase inhibitor N-terminal	Coggill P	pcc	CATH:1t6eX01	Domain	The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylanase.\	      Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.35	0.71	-4.29	111	1620	2012-10-02 15:32:34	2011-12-09 16:34:32	1	20	98	13	922	3319	9	167.20	27	38.32	NEW	YshplphGs............P...........h.hslDhu.ushhW.hpC....................................t...Ssoa....psl.C...........sSs.Ct.ht......................sssts..ssCthhs..s.....stsssG..pl.spDsl.hssst.t..................sshsshhFuC......ussth..............uh.t...........................sssGlhGLu.pst...hSLsuQlutt.....hsp+FuhCLss..............ssssGhlhFGs	..........................................YhhplslGT..P.sp.........hhlhlD.TG.S-lsW...l...p..Cpss.................................................................tshtt..shas.PspS.ooh..........ptlsC.................ss..s..h..Cptht.....................................tsss.s.s.s....s.C...s.....Y.p...h..p......Yus.......sosotG.......hl..spDslslsss...........................ssh.s.s.hsFG.C........upssp.............Ghht....................................sssG.l...lGLG....pus...................hS.......l.......s......o......Q......l...tt................hsstFSaC.Lss.................sssuhlhhG.............................................................................................	0	113	501	731
+14395	PF14544	DUF4443		Domain of unknown function (DUF4443)	Coggill P	pcc	CATH:2p8tA02	Domain	This is a family of archaeal proteins. The domain is a putative gyrase domain.	18.50	18.50	18.60	19.00	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.59	0.72	-4.16	8	29	2011-12-09 16:41:01	2011-12-09 16:41:01	1	1	29	1	20	33	3	105.00	30	52.94	NEW	FS.EsttV.u.VEGaPAYAIVVKNPPpFKSIELRDEAIRFFAKGAMILlVKNGElVFPEDtRPL+EThPELAE+L...l+h..--...GDhlVVTWAENPuDAhKSAhHVALsLKp-EI	.........................................hulhhtt.sp.h.c.u..l...-LRDEAIRasAcGAhIlhhKsGcllFP..E..DtcsL....c-hhs..cls..ccl...tph....c-...GDhlllThu-s.spAhpuhh...............................	0	4	5	13
+14396	PF14545	DBB	BCAP_N;	Dof, BCAP, and BANK (DBB) motif,	Coggill P	pcc	PROSITE, Pfam-B_2980 (release 26.0)	Domain	The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerisation. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions [1]. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling [2].	22.20	22.20	22.90	22.20	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.82	0.71	-4.67	13	113	2011-12-12 13:27:38	2011-12-12 13:27:38	1	1	63	0	61	137	0	136.40	37	17.33	NEW	FsVtP+Kl+sGps.+VhllLsp...sLpccsslpVphcpssps.....lssscpcNPYTlphssP-thhplSthVslplcpsshsLGs+slKCcScLcElpplLps...sssPlEFMCQulsIsPsspEpLDplLhpoFp+.NlPss.apLhu	.........sV.Pc+lpCGpptplalIl+s.....cLpcpso.sElEFpspsp.hh...phpsphcNcYTlshpAP-h...suGsVslplYssslslupssIpYYoshcElpplLpp...sssPlEFhCQAhtlsshspEsLDplLTpshKc.NlPssthpLht......	0	12	16	33
+14398	PF14547	Hydrophob_seed		Hydrophobic seed protein	Eberhardt R	re3	Jackhmmer:Q9S7Z9	Domain	This domain has a four-helix bundle structure. It contains four disulfide bonds, of which three function to keep the C- and N-terminal parts of the molecule in place [1].	23.40	23.40	23.40	23.50	23.20	23.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.24	0.72	-10.80	0.72	-4.08	24	532	2012-10-01 19:46:35	2011-12-12 14:20:06	1	8	71	0	253	530	0	81.10	49	49.60	NEW	sCPhssl.cLssCssVL.slhplhlGs..tsptCCsLltGLssl-AAsCLCssl+hplLs.lsl.lsl..slplllshCG.+s..PsGFpCs	................................pCPh..Ds.L..KLusCuslL..G.............L.l.p.lt.lG..s..........s...s......spsCCsLlpG.LsDL..-.AAl.CLCT.AlKAsl.L.G.......Isls.l.Pl..sLs.LLLNhCG.Kps....PsGFpCs....................	0	18	110	191
+14400	PF14549	P22_Cro		DNA-binding transcriptional regulator Cro	Coggill P	pcc	CATH:1rzsA00	Domain	Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth.  It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.62	0.72	-4.25	33	735	2012-10-04 14:01:12	2011-12-12 15:55:30	1	3	468	8	62	374	11	58.40	33	75.46	NEW	pKsDllpaFGuts+lApALGlopsAVSpW....G-hlPEhRAaplEclTsGpLKss...sslhpcss	.............h...cslsaa.G.o.ps.KlApAhG..ls..suV.spW.....sch..lPc.......t.......R.......Ah.plppsou.Gtlphp...........p...........................	0	11	27	42
+14401	PF14550	Peptidase_U35_2		Putative phage protease XkdF	Coggill P	pcc	Pfam-B_5816 (release 26.0)	Family	This domain is largely found on phage proteins.  In a number of cases the domain is associated with a SAM-dependent methyltransferase.	24.00	24.00	24.60	29.60	23.90	21.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.75	0.71	-4.50	35	118	2012-10-01 19:43:34	2011-12-20 15:14:30	1	3	106	0	21	108	166	123.60	35	38.81	NEW	hppplclh+........psp....--cplVaGlVhpPs......hhDucGDh....hss-EIEKAAapFhcp.....hpplDtpHch...psusuplVESaIsss.DhplsG...p..slp+GoWlhss+s...sD..p-lW-p....l+cG..choGaSluG...sAcph-h	...............tppVclh.ppsp....--p+lVaGlVhEPc......s.DuHGDa....hoA--IEKAAasFhpp.....hpplDhpHsh...psusupVVESalsPs..Dhplss.....p.plpKGoWlhss+ssD......-lW-p....lKcG..clTGaShuG...sAch..h...........	0	10	15	18
+14402	PF14551	MCM_N		MCM N-terminal domain	Bateman A	agb	Jackhmmer:O27798	Family	This family contains the N-terminal region of MCM proteins.  This region is composed of three structural domains. Firstly a four helical bundle, secondly a zinc binding motif and thirdly an OB-like fold [1].	24.90	24.90	25.00	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.38	0.71	-3.62	340	2275	2011-12-20 15:49:09	2011-12-20 15:49:09	1	42	484	10	1550	2224	62	132.50	20	16.40	NEW	hpcpF.ppFlpp...............ht..................................................................hYhpp................lpphhpp....p...p.........................................psL.lchp.cLtp..a..s..................................p....................pL.sp.t.lhppPtchl.s..hhcp.ulpchh.t.............................................................................h.spht...pc......tp......h.plphhsh............sp.............thslRsL.c..us..clspLlslpG	.................................................................................h..ptFppFLpp........apt................................................................phhY.hpp..........................lp.phhph......pp...........................................psL.Vsh.p.c.L.tp..a..s.......................................p.......................pL.sp.t.lhppPtchl.s..hhpp....Al...pchhhp.............................................................................hsstht..tp........pp......h.plp..hhsh.................sp...............hhslRsL..p..ss..plspLlslpG........................................................................................................................	0	540	876	1300
+14403	PF14552	Tautomerase_2		Tautomerase enzyme	Coggill P	pcc	CATH:3c6vA00, Pfam-B_819 (release 26.0)	Domain	\N	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.50	0.72	-3.96	157	646	2012-10-01 20:38:22	2011-12-20 16:17:50	1	4	541	17	193	1070	117	79.40	31	61.58	NEW	D+Fpllppa..csschhhs..sp.h..ls....sRocshllIpIssttsRohEpKptLYctlscpLpppsGlpspDlhlslsEsst.-sWSFG	...............................Dpaphhppa..p..s..pphhasst.h..Ls...hpRo.-s..h.lhlpIssttsRohcpKcpLYptlsppL.pppsGlpspDlhIolhEss.t.-sWSFG.......	0	42	99	150
+14404	PF14553	YqbF		YqbF, hypothetical protein domain	Coggill P	pcc	CATH:2hjqA01	Domain	This N-terminal domain is found in Bacillus and related spp. The function is not known.	27.00	27.00	33.20	33.00	26.40	17.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.93	0.72	-4.29	9	66	2011-12-20 16:42:37	2011-12-20 16:42:37	1	1	59	1	3	36	0	40.30	59	71.20	NEW	ltGpTYsshGp..hFhhs.EppVscchapYLpsNcaFplpc-.sp	..IpGpoahAas+..+FLhupEEcVSEKlYNYLRRNEFFEVRKEE..a...	0	1	2	2
+14405	PF14554	VEGF_C		VEGF heparin-binding domain	Bateman A	agb	Jackhmmer:B4YYD6	Domain	This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.	27.00	27.00	51.00	51.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.92	0.72	-4.16	5	153	2011-12-20 16:57:28	2011-12-20 16:57:28	1	2	59	5	32	137	0	54.20	78	25.52	NEW	cpcENpCEPC....SERRKRLFVQDPtTCKCSCKaTDucCKSRQLELNERTCRCDKPRR	................t...ps.CtPC....SER..RKHLFVQDPQTCKCSCKsTDSRCKuRQLELNERTCRCDKPRR......	0	2	5	13
+14406	PF14555	UBA_4		UBA-like domain	Bateman A	agb	Jackhmmer:A2AT02.1	Domain	\N	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-7.92	0.72	-4.42	201	1716	2012-10-01 23:03:33	2011-12-20 17:19:24	1	62	362	9	1068	1687	15	41.70	26	10.41	NEW	cphlspFh.slT.G..s....sp.....ppAppaLctssWsLctAlstaappspss	...................thlppFh.slT.G...s.....sp......stAtphLptssW..sL....p....tAlstaapt..............	0	328	522	821
+14407	PF14556	AF2331-like		AF2331-like	Coggill P	pcc	CATH:2fdoA00	Domain	AF2331-like is a 11-kDa orphan protein of unknown function from Archaeoglobus fulgidus. The structure consists of an alpha + beta fold formed by an unusual homodimer, where the two core beta-sheets are interdigitated, containing strands alternating from both subunits. AF2331 contains multiple negatively charged surface clusters and is located on the same operon as the basic protein AF2330. It is suggested that AF2331 and AF2330 may form a charge-stabilized complex in vivo, though the role of the negatively charged surface clusters is not clear.	150.00	150.00	155.20	155.10	29.70	17.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.18	0.72	-3.64	3	3	2011-12-20 17:20:05	2011-12-20 17:20:05	1	1	3	2	3	3	0	93.30	46	100.00	NEW	MPTYVFsKESFLKFLEKNLtEDsVVVVSSDVTDlDccpuESa.LGcK-aahVcFAlsADVFKEsDlDEFDEhhKYsVVFVESDEL.SEAG+KA.hR	MPTYVFsKESFLKFLEKNLtEDsVVVVSSDVTDlDccpuESa.LGcK-aahVcFAlsADVFKEsDlDEFDEhhKYsVVFVESDEL.SEAG+KAhR...	0	1	3	3
+14408	PF14557	AphA_like		Putative AphA-like transcriptional regulator	Coggill P	pcc	CATH:2rkhA02	Domain	Members of this family are putative transcriptional regulators that appear to be related to the Pfam:PF03551 family. This family includes AphA-like members.	27.00	27.00	27.10	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.72	5	13	2012-10-04 14:01:12	2011-12-20 17:41:38	1	1	12	0	5	54	17	175.10	40	93.05	NEW	asDNoLTPKEAVRLsALG.hIARuPhRYuDLAuAVRHFloRIsGPSLDLhGoSlELLRaEGLlEPlsGcGMEDNApLuIT-uGRpELpcLlTAsLRAu.SD.LuKLVIuLKLRFLDLLsscsRpcQIDsLLchsEoELARLsDL.RAAhuu-Gs..Lht-WLDp-IsQlEpRLuWLcuLt	.................................................atDNoLsP+EA.VRLssLG.hlAcuPt.R.Yu-LAu.u.V..RH.FhoRIhGPS.LD.LhG...oSlEhLR.aEGLl..E...shs...G..p..G.M.E...Ds.Ah..L.uIT-uGRpEhpsLh.sAslRss.oD.Lu+LVluLKlR....FLDLLss-pppsQl-tL..l-hsETELARLhDL.RA..A.s...s.s..s.G.s........hht-WLDp-I..sQsEpRLuWLcsL.h....................................................	0	3	4	4
+14409	PF14558	TRP_N		ML-like domain	Bateman A	agb	PF06011	Domain	This domain is distantly similar to Pfam:PF02221 and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding.	27.00	27.00	27.10	27.00	26.90	25.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.92	0.71	-4.16	62	432	2012-10-01 19:31:57	2011-12-21 11:00:42	1	8	131	0	325	430	0	145.30	28	17.73	NEW	chlposulssCh-s.Sphsss...............hFclpasssspolsaslsus......................................oslssp.VssplplhAYGhplh.scshc.Cs..hs..ht........tlCPlssGphsspus.hh..sp..phsspIP...uI.AYslPDLDApl.+lhlhsss........sspplAClpusloNGKTsp	.................................t.ltosuhssC.....hss.Sthsss...............hFslsass..s..s..p.o..lphslsus.....................................................................................os.hssp..lshplplhAYGhphh.sp.s.hc..Cs.....hs.....hp............slCPls.sG.p......hshpss.hl.....sp.....sh.sspIP...................uI.AYslPDl-Aps+lhl.tssp.............sspplAClpuploNG+Ts.....................................	0	61	158	265
+14410	PF14559	TPR_19		Tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q87RI8	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.06	0.72	-3.63	300	8943	2012-10-11 20:01:04	2011-12-21 11:26:45	1	1648	2991	20	2662	21075	6378	65.60	19	13.54	NEW	hltpu.....chspA....hplhpp...s.h....pt.....psp....sspsth..t.....L..Acshlpt.sphcp...ApplLsplstppps....sphp..sl...hApl	.................................................tps....chspA.........hphhcp.......s.h........pt...................pPp..........ssphtl.......t....................L.....Apsh.hpt.G...c.......hpc...........Ap.p...hL...pp..hhtpp.s............................h...................................	0	874	1638	2192
+14411	PF14560	Ubiquitin_2		Ubiquitin-like domain	Bateman A	agb	Jackhmmer:1t0y	Domain	This entry contains ubiquitin-like domains [1-2].	23.10	10.00	23.10	10.00	23.00	9.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.81	0.72	-3.73	85	602	2012-10-03 10:59:06	2011-12-21 11:57:51	1	38	292	5	409	5698	192	79.70	20	19.48	NEW	sVplplTpstsp..htsE...tRashshTlpplKpKLphhsGsssssMpLpL..h.spssphlssl..........s-..DsthLGtYs.lcDGhclHVlDpsPss	..................................................c...h+.ls.shTl.....sp........lKp+Lphl.sGl..ss.sshcL..h....h....t..p..s...s..t...h...tph.......................cp....sp.phLst..as.lps....s.....plhl.......t...............................................	0	159	216	322
+14412	PF14561	TPR_20		Tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q87RI8	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.76	0.72	-3.87	216	1831	2012-10-11 20:01:04	2011-12-22 16:10:40	1	21	1796	5	436	1379	539	89.00	34	30.03	NEW	pussss-lppLctpls...ssPsDh..pAphpLAhthhtsGch--AlcpLlpll++Dpsh........s-ssARppLlclFpslGss...DPhssphRR+LsolLa	..............................tssss-ltpLppplA....t.sPp.Dh..phthpLAh.th.htsG+s.E-Al-hLhshl++.D.h..st.................................s-...sp.sR+phh-lhsslGss.............Ds.lssphRRpLhulLa..............................................	0	116	257	352
+14413	PF14562	Endonuc_BglI		Restriction endonuclease BglI	Eberhardt R	re3	Jackhmmer:O68557	Domain	This restriction endonuclease binds DNA as a dimer. BglI recognises and cleaves the interrupted DNA sequence GCCNNNNNGGC and cleaves between the fourth and fifth unspecified base pair to produce 3' overhanging ends [1].	25.00	25.00	25.10	25.30	24.80	20.90	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.80	0.70	-5.56	3	4	2012-10-11 20:44:47	2011-12-23 09:30:11	1	1	4	1	2	6	2	287.50	47	97.46	NEW	RpclapSYppsRsYLlsNh-pLIclEpYsLsllsNlI+-NtEEI+ADYNE.AsaLaPFWpNYPPE-RGRtP+GDQIPWLEVGEKsVGSKLsRLVsp+hE.sVR-lGLPTGuDlRallos.pI.plTNshTDSsalFlDIKSVGPRDsDs-lVlSPNQVSGsG-.W-sFpsGIpNNphTI..pGsRu.NasFhPoLPPLYILSDGpIVPVVplaIKPVYuMlSLp.psDGGQPLp+IclASVPNGLLLFsNPsYuaspAacsLFpPGKDEhTKDsppRRlRVcLclLuRIusWRshcIDp	........................Rpcla.SYpps+pYL.sN.-...clEhYsLsllsplIp-NtEEI+ADYNE.AsaLaPFWhNYPP.-RG+hP+GDQIPWlEVGEKsVGSKLsRLVsp+.-.sVR-lGLPTGsD.Rallos.pI.plTNshTDShhhFlDIKSVGPRDsD.-lVlSPNQVSGsG-.WsthpsGIpNNp.TI..pGsRu..sp.FhPolPPLYILSDGpIsPVVplaIKPlYuMhSLp.psDsGQsLh+IclASVPNGLhLFsNPsYuaspAachLFpPGKD-hTKs.hp+RlRVcLclLs+Ius.RshpIDh..	0	0	0	1
+14414	PF14563	DUF4444		Domain of unknown function (DUF4444)	Eberhardt R	re3	Jackhmmer:Q1GJN9	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved LIPL sequence motif. There are two completely conserved G residues that may be functionally important.	25.00	25.00	42.90	42.20	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-8.06	0.72	-4.57	20	30	2011-12-23 10:42:36	2011-12-23 10:42:36	1	1	30	1	4	32	8	42.20	56	19.81	NEW	lGE-lThsG.....tTGTFlGVDEcFGMLLRsss.sTHLIPLTolLEs	.......lGEplThsG.....tTGTFLGVDEcFGMLLR-ss.sTHLIPLToLLEp.	0	0	3	3
+14415	PF14564	Membrane_bind		Membrane binding	Eberhardt R	re3	pdb_1yhp	Domain	This family includes the C-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 (Swiss:P54657), which has an immunoglobulin-like fold. It tethers the protein to the cell membrane [1].	25.00	25.00	28.70	75.60	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.42	0.72	-3.88	26	35	2012-01-03 14:41:10	2012-01-03 14:41:10	1	3	21	2	25	36	0	112.10	26	45.68	NEW	slsl+lh....sssssstpYphslpsapls...ssshposs-...Yshlslhshs..sspllsplsl+sppt.....GthlssGSlYF+Yssssuplshsc.s...psaPp..sLclppsspspFshsLhs	..........lsl+hh...sssssssppYphslpshpls...ssslhSsss....Yshlslh.hs..ssplVsplslR-pph.....GthlssGSlYF+Ysssssplshsc.s...-saPp..slclpcsspssFslsLh....	0	11	19	23
+14416	PF14565	IL22		Interleukin 22 IL-10-related T-cell-derived-inducible factor	Coggill P	pcc	Jackhmmer:Q9GZX6	Domain	Interleukin-22 is distantly related to interleukin (IL)-10, and is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family.	30.00	30.00	30.00	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.10	5	53	2012-10-02 01:28:15	2012-01-04 14:53:14	1	1	36	14	29	136	0	136.60	54	77.25	NEW	CRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNAC	...................................C+LcpSsFQpPYIsNRTFhLAcEASLADNsTDVRLIGcc.LF+G..V...s.h.s-RCYLMKQVLNFTLEEVL.......h...P.......p..S..D+...F.....p..PY....Mp....-V...V....s....F....L....u....+.....L.Ss+LSp..CHIp.G...D-...pH......I...Q+...N...VppLK-T.VKKL.G.E.s.G-.IKAIGELDLLFhsL+sAC...	0	1	2	6
+14417	PF14566	PTPlike_phytase		Inositol hexakisphosphate	Coggill P	pcc	Pfam-B_194 (release 26.0)	Domain	Inositol hexakisphosphate, often called phytate, is found in abundance in seeds and acting as an inorganic phosphate reservoir. Phytases are phosphatases that hydrolyze phytate to less-phosphorylated myo-inositol derivatives and inorganic phosphate. The active-site sequence (HCXXGXGR) of the phytase identified from the gut micro-organism Selenomonas ruminantium forms a loop (P loop) at the base of a substrate binding pocket that is characteristic of protein tyrosine phosphatases (PTPs). The depth of this pocket is an important determinant of the substrate specificity of PTPs. In humans this enzyme is thought to aid bone mineralization and salvage the inositol moiety prior to apoptosis [3].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.84	0.71	-4.16	103	540	2012-10-02 20:12:17	2012-01-04 15:56:02	1	4	197	33	220	698	17	143.50	25	39.58	NEW	lsLREEshs...............asNst....hshct...hps.tpp..l.t..hpuhsstplpphEpth+pclhtps........pphssphhh.................................t...................................................................hc.p.thspshslpYhRlPlTDcpsPpspslDthlphlcsh.sp..................sshlhFpCptGpGRTTohMlhhsllp	........................................................................................................lsLREEshs.................ahs.Gts....hoh+phps.hps...h.........h.shstppl-...phEt........tl.+pclhtps........pphtsthhhhpp.pph..........................ph.tl..............................................................hhc.p...hs..p..th..sh.p.Y..hRlPloD.p.p....t.P.p.p.pshDthlphlcph..sp.....................................................sshhhFpCpsGpGRTohhhshhshh...........................	0	90	144	182
+14418	PF14567	SUKH_5		SMI1-KNR4 cell-wall	Coggill P	pcc	Pfam-B_7167 (release 26.0)	Domain	Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	27.00	27.00	27.00	27.10	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.37	0.71	-4.70	27	120	2012-10-01 20:46:44	2012-01-04 16:35:07	1	2	109	1	35	225	9	129.90	51	92.78	NEW	Mc-lI-pLpphspssslsl-LPsp-pls-lEcplhlslPt-aKcaLhpsSDllhGslEPlolsDs.oHoY..LsEsss.Ahs.hGlP+-hlPI.CpssssaYCls.....p-Gp........VhhWs..cG...s-EpWtshapWsccVWl	......................Mc-lIEpL+E.hsE.sVPV..PL.EL.P.-.-.-pLVElEEpLhIslPhpaKEFLLps..SD.V.........lY.....Gs.l.............EPVT..lo......D..Pp.SHTY...........LPEV...su..pA.W-...lG..l.PR.-lIPl.Cp.-..G..csYYCl-........pDGp.............VhlWs...-s-l..o--sW-SlWpWscDVWL......................................................................	0	3	8	24
+14419	PF14568	SUKH_6		SMI1-KNR4 cell-wall	Coggill P	pcc	Pfam-B_725 (releawse 26.0)	Domain	Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.35	0.71	-10.69	0.71	-3.63	86	516	2012-10-01 20:46:44	2012-01-04 16:50:21	1	4	281	2	92	1001	10	112.20	18	72.41	NEW	ccpIpcsEppLul.....phPpsYKpFLcpYGu.ut.......hsGh-lhu.....h.................tsshhhtshh.t.ptthpp.htl.p.h.........llhpsssGphashc.........ps.scs.lh...........h.stptp.hhussFtEaL	......................................pIpphEppLsh.....phPps.Y+pFLcp.hsu.st..................h.s.u..p.lhs.....h......................................t.sh.hhpp.h...............htp.....ph..pph...............llh..p..s..s..s..s...s..h.hshc.........ptsps..lh.............................t.....p.....h.....h....hsssht-al.......................................................................................................	0	24	55	61
+14420	PF14569	zf-UDP		Zinc-binding RING-finger	Coggill P	pcc	Jackhmmer:A9T9M4	Domain	This RING/U-box type zinc-binding domain is frequently found in the catalytic subunit (irx3) of cellulose synthase. The enzymic class is EC:2.4.1.12, whereby the synthase removes the glucose from UDP-glucose and adds it to the growing cellulose, thereby releasing UDP. The domain-structure is treble-clef like (PDB:1weo).	27.00	27.00	42.80	42.10	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-9.87	0.72	-4.23	6	380	2012-10-03 15:03:13	2012-01-05 15:54:05	1	6	85	1	128	405	0	75.90	53	8.56	NEW	PKPLpNlNuQlCQICGDDVGVTl-GElFVACsECuFPVCRPCYEYERKDGsQuCPQCKTRYRRHKGSPRVcGD--EDDsD	...............suplCpICGDpVGls.ss.G-.sFVACsECuFPVCRPCYEYER+EGsQsCPQC+..TRYK.RhK.........Gs...Ptl.GD-.-.-.-.t....................	0	18	88	109
+14421	PF14570	zf-RING_4		RING/Ubox like zinc-binding domain	Coggill P	pcc	Jackhmmer:A5BM39	Domain	\N	27.00	27.00	27.00	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.35	0.72	-4.38	58	462	2012-10-03 15:03:13	2012-01-06 18:22:44	1	17	256	2	313	530	12	47.80	51	5.58	NEW	CPlCspch..DhsDpshhPC.pCuapIChaCapclhp.....s..t.....sGpCPuCRcsYc	.............CPLChE.h...DlsDt.sFhPC.sCGYQ...ICpFCapcIcp......s..t.........sGhCPuCR+sYp...........	0	101	187	261
+14422	PF14571	Di19_C		Stress-induced protein Di19, C-terminal	Coggill P	pcc	Di19_old	Family	C-terminal domain of Di19, a protein that increases the sensitivity of plants to environmental stress, such as salinity, drought, osmotic stress and cold. the protein is also induced by an increased supply of stress-related hormones such as abscisic acid ABA and ethylene [1]. There is a zinc-finger at the N-terminus, zf-Di19, Pfam:PF05605.	26.00	26.00	26.40	31.30	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.53	0.72	-3.72	49	170	2012-01-09 11:51:23	2012-01-09 11:51:23	1	4	26	0	88	170	0	98.50	30	47.24	NEW	slSlLp+...-L..R.-upLQuLL.GGu......sss.s..s...uo.ssusDPLLSSFlhsh.ss.scs.p...c..ssc..s...sssst....pc.s.Stpcphs..pp..sh..p.t.s..pss.LStc-pE....EpspRucFVQsLLlSTl	.......................hShLt+-Lc..-upLQsLLGGu.......tsts...s...ss...s.sssDPLLSSFlhshss.scs.p...pssp..s...sssst....ss.sshtpphs..pp.sh.p.....pss..Lopc-p-....c+spRupFVQtLlhSTl..........................	0	14	55	73
+14423	PF14572	Pribosyl_synth		Phosphoribosyl synthetase-associated domain	Coggill P	pcc	pdb_2c4k; Jackhmmer:Q14558	Domain	This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.	27.00	27.00	27.20	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.17	0.71	-4.54	11	6166	2012-10-10 14:25:38	2012-01-09 15:06:51	1	16	4467	28	1767	4367	2278	127.90	40	39.16	NEW	DYRNAVIVAKsPuuA++ATSYAERLRLGlAVIHGEsK-u.EsDh.sDGRpSPPsh.cs.............sslsssht..lPhhhsKEKPPlTVVGDVGGRIAIIVDDlIDDlpSFVAAAElLK-RGAYKIYVhATHGLLSuDAPcLlE-SsIDEVVVTNTlPH-lQKhpCpKIKTVDISllluEAIRRIHNGESMuYLFR	...............................................................................................................ptsssp..............................................................................................................................................................................................s.......M....p....l.I.G.D..V..c.G+..ss..lll...........DDhIDT...uGTlsp.AAc..s......L.c.-.p.G.Ap.c.VaAhs.TH.....ulh.S...G......s.......A...h.....-....p....l....p....s....S....s....l....c....E..lVVT.........D..T..I...s........l....s..c...t.........p..p....h....s....+.l.........c.hl.o...lu...s..l..lAEAIc.Rla.pp..cSlSsLF.p........................................................	0	573	1057	1460
+14424	PF14573	PP-binding_2		Acyl-carrier	Coggill P	pcc	CATH:3ce7A00	Domain	\N	32.00	32.00	32.00	32.00	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.40	0.72	-3.95	5	15	2012-10-02 01:16:24	2012-01-09 15:11:50	1	2	10	1	12	80	1	91.30	44	35.82	NEW	SPVVDTDINAVTNYIVGMCQKFLQKGEKVTPSSKLEELRTREDRLWDCLDTVEFVLDVEEIFDVTVPDEVADNFQTLQEIADFVVSERAKAGKFMK	................................................lpphllGhhpKaLpcspclTssoKLE...EhRT.+-sRhWDsLDTVEFVlDVEEhFDVTIPDEsADNhcTlQEIADaVVupRt................	0	7	8	11
+14425	PF14574	DUF4445		Domain of unknown function (DUF4445)	Bateman A	agb	Jackhmmer:C9L8Q5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 525 and 664 amino acids in length. The family is found in association with Pfam:PF00111.	27.00	27.00	29.30	40.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.02	0.70	-6.24	215	536	2012-01-09 17:49:09	2012-01-09 17:49:09	1	11	362	2	223	535	496	400.20	34	68.91	NEW	haGlAlDlGTTTlsutLlDLp...o.GchlussuthNsQhpaGsDVlSRIsaAt..p............sGhppLpptll.pslNpllsplhpp.......ss............................lshpcIhplslsGNosMpHLhLGlssptl........utsP........ahPsh..........sps..h.lpAp-l..Gl......phssputlalhPsluuaVGuDllAull.uss..ht.....p....p..cc..hs...LhlDlGTNGEllL...G.sp.cpllusSsAAGPAFEGusIspGM+AssGAI-cVpl....csss.............ph.psIG......................s........................ttP....................pGICGSGll-hlAplhcsGllcpsG+hsps...tt.............t.h.h.t.t..ttttalls...tt.......t.......t.h.......scslhloQpDI.cplthAKuAlhAGlphLlcc.sGlshs-l-clhlAGuFGsalshcsAhslGllPc.h.hp+lphlGNuuhtGAphsLls............................pptpcchpplscph..p..alEL...usp...ssF.pctFlpuhhh	............................h.aGlAlDlGTTTlsstLlDLp.........s.GcllspsuthNsQhpaGsDVlSRIsauh..p............sGhppL....ppslh.pslNpllpplhtpss............................lstppIhphslsGNosMtHLhLG.lssppLutuP........ahss..h..............pps..htlpAp-l...ul.............plps.tutlalhPsluuaVGuDhsAull.ust..h.t..................p....p..cc...hs..LhlDlGTNGEllL......u.sp....spllusSsuAGPAFEGusIssGhRAssGAI-cVplssps.................phpsIG...............s........................tts..............................................tGICGSGll-hlAphhcsGllcpsGchtps....t...............h...h...ttttphhls.t........t..th.spslhloQpDI.+plQhAKuAlhAGhphLlcp.hGlphpcl-clhlAGuFGsalshcsAhslGllPc.h.hp+lphlGNuuhsGAphsLL.s............................pp..ttpch..pclsppl..p..hlEL...usp...ssF.pctFlpuh.................	0	111	190	207
+14426	PF14575	EphA2_TM		Ephrin type-A receptor 2 transmembrane domain	Coggill P	pcc	CATH:2k9yA00	Domain	Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor.  This domain oligomerises and is important for the active signalling process.	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.87	0.72	-3.58	64	1068	2012-01-09 18:22:38	2012-01-09 18:22:38	1	47	82	50	462	762	0	77.70	37	8.58	NEW	hllsu.ss.su..llhLllllh.l....h.l.hht..RRpp.hp..........+s...pp.p..s-c..h......th.pssp.....h..h...su.....l....................Ks...............YlDPaTYEDPspAV+EFA+EIDs	......................................................h.lhssss.su..lhhlls.l.l.s.h.....hl....lht....R+.....pp...hp...................................+s..pp..p.....s-c.....................ph.tpsp.........h..h.PG..h.........................................................K.s...........................Y.....lD....P....aT.YEDPNpAV+EFAKEIDs............	0	46	86	226
+14427	PF14576	SEO_N		Sieve element occlusion N-terminus	Eberhardt R	re3	Ruping B	Family	Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation [1]. This domain represents the N-terminus of SEO proteins.	27.00	27.00	63.20	32.00	22.90	22.40	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.82	0.70	-5.13	34	105	2012-01-10 14:54:50	2012-01-10 14:54:50	1	6	13	0	58	98	0	247.50	32	38.72	NEW	t.sDsplhcplhtTHssDs.cchDVcsLhsllpsIlp+us.hs............h..tt......t..p..cp...s.hshhcs.hhslc+ISCch.sKssutp.sAH.............pTThsILphLssYoWDAKsllsLAAFALpYG-FWhLsph.hsos.LAKSlAhLKpl.s..hp.ts...+sR.ss...lssLlcshlpVhcsIhEaccLssp.Y.....spDVPuLstAhpcIPlsVYWsItolVACsupIssl.........hspp..csaELS.shspKLssIhs+L+ppLshCcppI--...hEsYppLhclFpps+p	................................................sDs.hhcplhhTHs.ss..pchDscsLhpllpsllppss..h.....................t..p......hs.hc.s..htlcpIusphhsps..utt.puH.............tTThsll..sh.LssYoWDAKsVlsLAAFAlpYGcFWhLsph..s..ss.LAKSlAhLcpl.P..hp......+s+hps...lssLl+shhpVscsIhEaccLsst..Y......spDlPsLssAhpcIPlsVYWsItolVACsspIssl................h.t......................p..pt..........a-LS.shspKls.IhpcL+ppLphChppItc...h-tat.hhphhpp.p....................................	0	3	46	55
+14428	PF14577	SEO_C		Sieve element occlusion C-terminus	Eberhardt R	re3	Ruping B	Family	Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation [1]. This domain represents the C-terminus of SEO proteins.	26.00	26.00	31.60	35.60	25.20	22.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.61	0.70	-4.99	35	115	2012-01-10 14:55:34	2012-01-10 14:55:34	1	6	13	0	69	112	0	213.00	34	34.22	NEW	pscEEsLhpc.sWhh-llsc.lDPhlhpWlp-s..+YIhlYGGsDh-WIpcFTpsscslu.......psAclslEhhaVGKt............................pD.shlhaFWsclEShh.hoKh.ph.............cpscsDslhQE.lpplLSacts-pGWAlLSKG...ss....lhlpG+Gsshlpols-a-t.WKcpV.p.cGFshAFc-Yacplp...s..sccCs+l.l.Psss..GcIP-plsCP-..CuRsME.palsY+CCHc	........................s..ccctLhpc.pWhhpllhc..........lcstl.phlc-s.+aIhlYGGsDhcWIpcFTpssctlt.......psAcl.lEhhaVGKtp..........................h...pD.shlhhFWh+lEShhhSKh..ph.h...........ppspsDshhpE.lppLLsac.t.sptGWAll.o+G...ss....lhlpG+Gsshhpols-ast.WK-pl.p.cGFshAhp-ahpphp.....s...sc.Cs+h.h.ss.ts...Gplscp.lhCs-..CtRsME.pal.YpCCp................	0	3	56	66
+14429	PF14578	GTP_EFTU_D4		Elongation factor Tu domain 4	Coggill P	pcc	CATH:1xe1A00	Domain	Elongation factor Tu consists of several structural domains, and this is usually the fourth.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.66	0.72	-4.34	11	354	2012-10-05 12:31:09	2012-01-10 16:40:20	1	15	284	4	219	555	91	86.20	37	11.07	NEW	hpssGKhpV.psaslht+-.slVG.cVlpGlIhPGYKl...KG+c.VGhIhpIp+p+KpV-FAlsGD+VAl.lEG.hh...psc-GDlLEV	.........hh...Ps+l+IL..PpalFppp....DPlVlG.VcV.sGhlK.G.sPls.....pccG..h.c...l...G.h..lp.oIcp.sc.K.sV-.A+cGpcVulpIcs.......................................	0	72	122	170
+14430	PF14579	HHH_6		Helix-hairpin-helix motif	Bateman A	agb	Jackhmmer:C9L7X9	Domain	The HHH domain is a short DNA-binding domain [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.89	0.72	-3.94	364	7029	2012-10-03 02:11:09	2012-01-11 15:39:14	1	48	4452	9	1533	5939	2559	91.90	30	7.87	NEW	GlpllsPDlNpSp.h.c.asl............................................pst.........s......IRhGLsslKGlGpssscpIlp.tRp...tus...Fp.sltDh..hpRs..............tls+cslEsLhpAGAh.D.sh.....u..h...p..Rt..tL	...................................................GlplhsPDlNp.St.h.c.Fpl...............................................................................................................pst.........ts.........IhhGls...Al+GlGps.sscpIlc..sRp.....p.....G................Fp.sl.Dh..tpRs..........................ttls.+.+s.l.EsLhpuGAh.D.sl....s......p.Rt..........................	0	538	1027	1307
+14431	PF14580	LRR_9		Leucine-rich repeat	Coggill P	pcc	CATH:1a9nC00	Repeat	\N	30.50	30.50	30.50	30.50	30.40	30.40	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.95	0.71	-4.71	6	1482	2012-10-02 21:32:02	2012-01-11 16:43:36	1	116	303	11	910	1732	20	148.50	27	32.21	NEW	MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIA	.....................................................h....................................................................h.p.t.lt......h......p....h...c....h...L...s...ls..pN.t.l..p....p...l....p..........s...l...s.....................p............L........p...p........Lcp.L.......Ls..sNpI....s..p..l...........p..s..l.t.....t.....t..l..s...s..Lp.........p...Ls..L..s.sN..p.I...p..s..l.s.............s......l..p.......L..p..p.l...p..p.LppL..s...L......h.....s.....N...P..........l............s............p...........h............p.........p.Y....R.....hllhh.lP.p...Lc.hLD.hppl..ptp........E.+.t.A...............................t.tt..............................................	0	313	425	643
+14432	PF14581	SseB_C		SseB protein C-terminal domain	Bateman A	agb	SseB	Domain	This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli [1] and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon [2].\	This presumed domain is found at the C-terminus of SseB proteins.	19.90	19.90	20.00	20.30	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.07	0.72	-4.20	72	744	2012-01-11 16:51:14	2012-01-11 16:51:14	1	7	695	0	82	441	11	108.70	51	42.24	NEW	p..shp....sGsplpls...cP..pc...Psphhsulsp.hhppptsVppAalthhpp.......tsppsshhlsl-hss....chppl.hpshup.hssshhss.hslchshls.s..tsluchhhpcspPFYpR	................EGGESLlLS...EV....AE......PPuQMIDSLTT.LFK.TlKPVKRAFlCuIKE......pp-AQPNLLIGIEADG.....DIEEI.IpAsGs.VATDTLPGDEPIDICQV+.c.GE....cGISHFlT-HlsPFYER............................	0	15	39	61
+14433	PF14582	Metallophos_3		Metallophosphoesterase, calcineurin superfamily	Coggill P	pcc	C0ATH:1uf3A0	Domain	Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	28.20	28.20	28.20	28.20	27.80	28.00	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.62	0.70	-5.23	6	31	2012-10-02 19:15:56	2012-01-11 17:04:52	1	2	31	9	11	163	10	169.80	37	57.98	NEW	M....thhscKlLAlSsh+Gch-hl-+LlclltEp.ssDAllllG-lhpspA+ucEYt............................pFFRtLuphslPsahlPGspDAPlchaLRtAaNhElVhPpl+sVHcoFAhhtG.allAGhGGElT-cucs-...thtL+YPuWEAEYpLKhL+-L+DhpKlhLFaTsP.......hcKGhccuGSpsVAcLlKTasPclVls.....uGsstcH..E.LGsoLVVsPGuLuEG-YAllDlcp+cl-hGsl	......................................................................................................................................................................................................................................................................................................................................................................................................h.L....p.....-.............h.......c..c.........ph.......I.....hl.F.Ht..PP.s.............htp..sh..u..csGS+sVtcLIpp..a.pPlls.Ls.....GHltcsp.t.h-plGs.Tl..lVNPGu.L.tp.G..-..aS..l..lshp...t............................	0	5	9	11
+14434	PF14583	Pectate_lyase22		Oligogalacturonate lyase	Coggill P	pcc	CATH:3c5mA00	Domain	This is a family of oligogalacturonate lyases, referred to more generally as pectate lyase family 22.  These proteins fold into 7-bladed beta-propellers.	30.00	30.00	30.00	30.40	29.90	29.20	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.16	0.70	-6.01	4	173	2012-10-05 17:30:43	2012-01-11 17:11:27	1	3	156	4	47	139	10	353.20	48	90.58	NEW	MAKGKhlsLsFcTa.DSsTsscVsRLTPsDVlCHRNYFYQKCFTpDGpKLLFuGsFDGshNYYLLDLsTQpAsQLTEGpGDNTFGGFLSP-DcuLFYVKNt+NLMRVDLsTLEEssIYpVP--WVGYGTWVANSDCTKlVGIEIpKcDWpPLTDWKKFtEFYaTNPpCRLI+lDLcTGEupVILQENpWLGHPIYRPhDDsTVAFCHEGPHDLVDARMWhINEDGoNhRKVKpHA.GESCTHEFWlPDGSALAYVSYhKGpopRaIhpssPsTLENcplhpMPsCSHLMSNaDGoLMVGDGssAPVDVpDsuGYKIENDPFLYVhNhKstpha+lA+HsoSWcVh-GDRQVTHPHPSFTPDDKtVLFTSDs-GcPALYhAclP-pl	......................................................................MAKG..l.Lpacsh.DspTGspVsRLTPs-lhCHR.NYFYQKCF....spD..Gs+LLF.uut...F..D..G.hNY.YLLDLtoppAsQLTE......Gt.....G...DNT..F.G......GFLS.s....-.D..culaY.VK..........st...+......sL.hcV-LsT..L.........c.....Ep.slYpVs..........-cWVGY.GTWVANS...D...CT+.lVG.I...E..I....t...+p.....................DW...pPL....s....DWp.hFp-...FaappPpCRLh+lDL....c.....T..GE...s...pVIhp.-spWLG.HPIYRPaDDsTlAFCHEGPHDLVDARM..WhlN.cDGoNh..RKV..+....pH.s.t.G...ESCTHEFWlPDG....SAlsY.V.......SY.h..K.G...ppsRh...IhphsP.............p..T......h...cs..c..t..l..hpM...P.s...CS...HLMSNaDGoLhVGD..G...u..ssPVDV....p......D.ss.u...YpI...-.N...DP.aLY.l.h.sh.p.s.........tp....t...+..lu+.....Hs..o......SWpV...hcGcRQV.T........H.....PHPSFTPDs+tVLFoSDh..cGp.PAlYhsplPt............................................................	0	7	25	36
+14435	PF14584	DUF4446		Protein of unknown function (DUF4446)	Bateman A	agb	Jackhmmer:C9L935	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 165 and 176 amino acids in length.	24.00	24.00	24.40	24.30	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.70	0.71	-4.38	123	292	2012-01-11 17:19:42	2012-01-11 17:19:42	1	2	289	0	74	243	26	149.80	32	86.90	NEW	.shl.....llulh.llslll.hl...hhlhhhh+...hp+lp++Ycthh....cGpsup.sL....Echlhphhcclcclppptcph.ccphcplppphp....pshpKlGlV+YcAFp....-hGucLSFulAlLDspssGllloula.uR-sshsYsKslppGpSp.htLSpEEppALcpAh	.............................s.hlllslh....llhllh..hl..hllhhhh+hp+Lc++YcthM....cGpssp.sL......Echl.hphhcclcclppptc.ph.ccphpplcpphp....pshpKlGlVRYsAFc....-hGucLSFulAlLDspssGllloula.uR.-p.ohsYuKsIppGpSp.hsLSpEEppuLcpAh..............	0	44	65	69
+14436	PF14585	CagY_I		CagY type 1 repeat	Bateman A	agb	Bateman A	Repeat	This repeat is found at the N-terminus of the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells ([1]).	25.80	25.80	100.40	25.80	17.60	25.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.27	0.72	-4.04	7	210	2012-01-12 14:30:43	2012-01-12 14:30:43	1	33	32	0	3	213	0	62.60	78	9.99	NEW	ETSKKsQQcSPQDLSNEEATEANHFED..KESKESSDpHLDNsTET.KTphD-s...KopETpsphspp	.........ETSKKTQQHSPQDLSNEEATEANHFEDSSKESKESSDHHLDNPTE.....T.....KTNFDE.KSEEhpsp.ss.............	0	3	3	3
+14437	PF14586	MHC_I_2		Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2	Coggill P	pcc	CATH:1jfmA00	Domain	Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.	27.00	27.00	27.40	27.20	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.17	0.71	-4.69	3	89	2012-10-03 22:02:01	2012-01-17 15:53:59	1	3	17	5	26	189	0	164.60	45	74.91	NEW	DAHSLRCNLTIKAPTPAD..WhEVKChVDEILILHLSNINKTMTSGDPGETANATEVGECLTQPLNDLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGDLVQQLKYFIPpCRQKIDEFLKQSKEK	........................................sHSLshNFT.I.Ko.ho+PGp.WCEuQs.hsc.phFLpa.s.ss.N.hsh.P.L.G..l.GKK.VNATpsWs-LTQsLs-lGc-LRhhLh-lKsp.h...K.TS.Gs.s......T....L.QVpMlsQ+cstphsuASWpFs.IssphshlF...D.s...hNMoWplIN.-AscIhEpWKcD+sLtc.ah.+.h...h.s.DCsphLcEFLt.....t.........................................	0	1	1	7
+14438	PF14587	Glyco_hydr_30_2		O-Glycosyl hydrolase family 30	Coggill P	pcc	CATH:3clwA02	Domain	\N	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.38	0.70	-5.53	4	205	2012-10-03 05:44:19	2012-01-18 13:33:11	1	21	143	6	97	244	11	287.10	27	49.98	NEW	cppLslshposaQpIDsFGASDAWRsQalGKNWP.EK+ppIADLLFSpEhDppGNPKGIGLShWRFNIGuGShEpGcsuGlsspWRRsECFLot-GsYDWsKQuGQpWFh+AARERGVpphLsFS.SAPhaMT+NGpuhoo-cs.phNlppsKhcsaAcFLs-sspph.pc.GhslNYlSPlNEPQW-W.usuuQEGo.sTN--hpchVphLD+cLpcRplsTp.IslsEsGsIpYLacs.sNtpsRDN.IcshFspsuphSlhpLssVtpsVouHSYWSsaPhspLVspR+pLspclup...ush+aWtoEYC.hEp..Ns-.spGsGs.RDLGMpsALYVARlIHpDLTlANASuWQWWTAlSthsYKDGLIalDcsp.tsG.Sh.........KpDG	...............................................................................................................ht.....lp.tt.hQ.phcsaGsS.sW...hp..h.h....G...hst....t....pp....p.pls-hLFo..p.p........................p...G...l...GLolhRaNlGuG............us.t..p.....t........p............s...........s..t....l..t.........s...............h...h......p....s...p.........s.a.......h.......s...sc.........s...s.........a.........s......W...s..t...s..t..u.QRh..h.l.p.t.A.+.p..+..G.ls..p....hh...uFu.NSP...PhahTpNGt.....s...s.s.....s......s....t....s.....s.....s.............NL..cs....-p.apsFApYLusVsc....th..pp..........t.......G.l.phshlsPhNEP.s...h..s...........W.....s..........s.....s........p..........QEGs..ths.s.p.p..sphlp.h.Lspp.lpppsl..s.sp..l.h.h..s-...................................................................................................................................................................................................................................................shttst.....................................................................................................	0	34	71	91
+14439	PF14588	YjgF_endoribonc		YjgF/chorismate_mutase-like, putative endoribonuclease	Coggill P	pcc	CATH:2otmA00 	Domain	YjgF_Endoribonuc is a putative endoribonuclease. The structure is of beta-alpha-beta-alpha-beta(2) domains common both to bacterial chorismate mutase and to members of the YjgF family. These proteins form trimers with a three-fold symmetry with three closely-packed beta-sheets. The YjgF family is a large, widely distributed family of proteins of unknown biochemical function that are highly conserved among eubacteria, archaea and eukaryotes [1].	35.00	35.00	37.20	36.70	34.20	34.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.80	0.71	-4.28	2	1260	2012-10-01 19:40:00	2012-01-18 13:58:18	1	6	1017	15	475	1093	1483	146.50	44	92.19	NEW	EoRLhAhGL.LPcssAAlGsYEPauhhus.lhTShQhPa.ttpLha.G.LGsshosp-GhAAsRLssLNulAQLtpAsGpLupl.plhRL-GhlsspQsh.-hPhsLDuAScLL.-lhGEtGRHuRhhhsp.VMPLsu.shlhhFAEl	....................................................t+LtpLGlpL.P..t.s.....ss.P..s.A.sYVPsl...p.o....G....s.h.l.a.sSGQlP...h....h..s..G...p.....l..h.hsG..K.....l...G.......s.........-.............l....o..s...Ep..upp..A...ARh...sAlNhLAs.lc...u...........t.........l....G......s.......L..-+.lpRlV..KlsGFVsS..sssF.....s.pQ...s......tVhNGAS-LlscVFG.-.s..GcHARSAVGVusLPhsusVEl.Eh...................	0	150	300	384
+14440	PF14589	NrfD_2		Polysulfide reductase	Coggill P	pcc	CATH:2vpzC00, Pfam-B_200168	Domain	Bacterial polysulfide reductase is an integral membrane protein complex responsible for quinone-coupled reduction of polysulfide, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfides are a class of compounds composed of chains of sulfur atoms, which in their simplest form are present as an anion with general formula Sn(2-). In nature, polysulfides are found in particularly high concentrations in extreme volcanic or geothermically active environments. Here, the reduction and oxidation of polysulfides are vital processes for many bacteria and are essential steps in the global sulfur cycle. In particular, the reduction of polysulfide to hydrogen sulfide in these environments is usually linked to energy-generating respiratory processes, supporting growth of many microorganisms, particularly hyperthermophiles.	27.00	27.00	28.90	28.60	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.74	0.70	-4.72	3	4	2012-10-01 19:35:38	2012-01-18 15:02:00	1	1	4	8	2	10	1	254.00	66	99.22	NEW	TEFYGLPNApEFWHWTNLLHFlLVGLAGGsAFLTALLHLKGcAEARRYTLaALuLIALDLFlLWAESPARFRFTHVWLFLSFHPTSPIWWGAWGLALSFLouGLLYLGKGPuRsLAWuLLlFSLVALAYPGhALAVNLNRPLWNuLLAGLFPLTALVLALGVAVLLKSuWALaP.LRVLAGASLhLAhLYPlTLs...sEAR..GHLWEEGGhhYGLFLLLG....LGAFhpERLAPWAGhLAAAG...LRALLVtsGQWQGL..G	......TEFYGLPNAtE.FWHWTNhLHFlLVGLAGGsAhLsALLHL+G..psE..ARRYTLh..A..LuLIALDLFlLWAESPARFRFTHVWLFLSFHPsSPIWWGAWGLA.LuFLouGLLYL..G.KG...P......pRhLAW......uLLlFSLVALuYPGhALAVNLNRPLW...Nu..L.hA.GLFPLTALVLALGlAsLL+SsWA...LaP.LRl.LA....GASLhLAhL.YPhTLs...sEAR..tHLhEE..GGhhYGLFLLL.G....LGsFhpERhAPWAGhLAAAG...LRALLVhsGQWQGLG.........................................................................................................	0	0	1	2
+14441	PF14590	DUF4447		Domain of unknown function (DUF4447)	Eberhardt R	re3	Jackhmmer:Q8EAP9	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length.	27.00	27.00	314.00	313.80	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.13	0.71	-4.66	5	28	2012-01-18 16:17:44	2012-01-18 16:17:44	1	1	28	4	13	19	1	166.00	82	99.49	NEW	MSKNlGLNAIEMQYLRpSLGLTsAQVAplTKsSE-DVlAWEAGEppAPtLAQKKLLEIDEIIEMQVLNToDGIEELFKKEPKRRLAFVVYPTQAlYTQYNPEFLSSLPLTELYNTAAWRIKKECKLVLEVDVoLVPLDVEuYKAYREcNGLuESRESRAKWAATQL	MSKNIGLNAIEMSYLRQSLSLSsAQVGpLTsHSEADVLAWEuGEpsAPELAQKKLL-IDDIIEMQVLNTCDGIEELFKKEPKR+LAFVVYPTQAlYTQYNPEFLSSLPLTELYNTAAWRIKKECKLVLEVDVSLVsLDVEAYKAaREpsGhSESRESRAKWAATQL	0	1	2	8
+14442	PF14591	AF0941-like	NTP_transf_5;	AF0941-like	Coggill P	pcc	CATH:1yozA00 	Domain	Members of this family are of unknown function.	22.60	22.60	22.60	23.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.74	0.71	-4.08	6	11	2012-01-18 17:29:05	2012-01-18 17:29:05	1	1	11	2	9	11	0	107.20	28	84.46	NEW	hpsTal-KltELh+.....t.hl.-stcclEclscpLh........scEsItEh..F+pDhE.IlchapsGchocEEAhppLp.Lc.hA.spLppah.clt-lLcchEtchpchltch.c.........ls..l.Y.hcp....lcpstcE	....ohl-KLtELlp.....pplIsDlp-cL-EIhcpls........scEpIcEh..F+sDhc-llc-hpuG-I--EEApcllc.l.......................................................................................	0	1	6	9
+14443	PF14592	Chondroitinas_B		Chondroitinase B	Eberhardt R	re3	Jackhmmer:Q46079	Family	This family includes chondroitinases. These enzymes cleave the glycosaminoglycan dermatan sulfate [1].	24.00	24.00	24.20	24.00	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.61	0.70	-5.66	6	114	2012-10-02 14:50:22	2012-01-19 10:54:16	1	13	78	4	66	132	31	320.70	28	50.89	NEW	VSo.sELtcAlspsKsGspIlLKsGlaKDVQIKFpGcGTK-pPIsL+AETsGKVFIEGsSpLEluGcYLlVcGLaFKNGaoPspsVIuF+su.cs....luNas+VTNCVIp-FspssR-psspWVp..thhG+HNclspChlsGKsNhGPTlRls......lcGsp.ultNYHpIVpNHFGPRPpKGGspGETIQlGsSaoSMoPu+ThlsNNLF-cCNGEVEIISSKoNFNla+NNlFacSEGSlVhRHGNYsslDGNaFIGssssEsYGGIRlINTGHWlsNNYFYtlKGppFRSslAlMNGIPKSPLNRYNQVTDVVVAYNTalDss.SPaQFGVGpNlsppDVLPcSEIRSARPhRhplsNNllaNcc.scphPllcp...Dcs...sFKsNhlssp.ss.......Lhsp.ctshTclutNhps.ps.....sshK.DlEsh.pGFDF-	......................................tplppAl..p.sspsGDpIlLtsGsa....s...s...h.p...lhh.p.s.pGTpspPIslpAps..sG.pVhl.s....G.....pu.......p.....lpls...........G..p............alhlpGLhF.p.suh.....ss.t..tth.hthp.s..........husps+lT..pssh....t..a....s.................tp.....t.......t...........al..............hhGppspl-ps.h.s...K..pshGsh.lhl...................tstt...s.tp..hc..p.I....cpNaF...t........p..........h........u....u........N.uu....Eslpl.Gh..S..t.u..h.s...u.shlppNhFcpss..GE.sEllS.KSstNhhptNshhpspGslshRHGp.shlpsNhalGst.......................hGGlRlhspsphlhsNYh.sh..........p..G........h........t........h..h..ushs..........hps....................s.t....s.........s.ta...s.p.s.l..Nshlsst....h.hs...................................................................................................................................h...........................................................................................................................................................................	0	19	53	64
+14444	PF14593	PH_3		PH domain	Eberhardt R	re3	Jackhmmer:O15530	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.21	0.72	-4.14	31	202	2012-10-04 00:02:25	2012-01-19 14:29:39	1	8	127	7	132	503	8	102.20	47	18.57	NEW	shWcpFlp...sclIlKpGhlpKR..+GLF..uR+RhLLLT-u.....P+LhYlDPspMhhK.GEIPWo...ppLpsEsKNhKpFalHTP.....sRsYYLpD.......scupAhcWscsIpclppphhp	........................................WcpFl-....splILKhG.VcKR.....KGLF.......uR+RpLLLT...-G................P.....+L.......hY.V.DP.s...s......h..l.l..K......G..E..I.PWS.........p.-.L..+....s...........E......s.......KN.....F.......K......p........FaVHTP...........sRTY.a.L...D............sp.u.p..A.hc...Ws+tIp-lhc....p........................................	0	58	76	109
+14445	PF14594	Sipho_Gp37		Siphovirus ReqiPepy6 Gp37-like protein	Bateman A	agb	Jackhmmer:C9LCM0	Family	This family includes numerous phage proteins from Siphoviruses. The function of this protein is uncertain, but it is related to Pfam:PF06605. In Rhodococcus phage ReqiPepy6 this protein is called Gp37 [1].	26.10	26.10	26.30	29.60	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.90	0.70	-5.20	43	160	2012-01-19 16:55:40	2012-01-19 16:55:40	1	2	128	0	25	151	20	326.20	24	86.66	NEW	shphlG.......................l-sap..SLpasc+a.tssGsFE...lclshsppp.................hphL.ppsshlhh...pstp...p...........ssllp..phphsp-p...tpsplsVpGhs.hpshlscRlshss..........h.......hhsussEslhcphlspsshssspssRtIs...sLt..lussts...tupplshp.spa.csLh-tlppl......spssslGaclh.........hc.p..............p..pch.lF-lhpGpDh.......sssllF.....StcasNlpstpatpos.sapNssh.VuGpGEGp.sRthsp............l....us.....s..p...GhcRcEhalDA+-ls.................................phhspLpp+GppcLs.Ettthtshcsplpssst......hhYtpDasL.GDhVolpscth..GlphsspIoEl.........p-ha-..psGh.plpssFGs	....................................p.hu..l-.apSlphpcpa.tssusFE...lhhshptt..................hchl.ptsshlhht..ss..............sullp..thplpps-...ttphlslpGhs.hpuhlscRIlhs...........h.......phoGpsEslhcphlppphh.s...tRpls...tLh..lsssts...ps.tsl.p.hp..spa.pslh-tlppl......spssshGaclh.........hs.p....................................p...tth.hhchhpu.pDh.......ssslhF.....St-ac.Nlhstpapcst.shpsssl.luGcGEGp.sRphsp.............................l................ss.....h..s.........GlcRhEhalDA+-lp.................................thhspLpp+Gpc+Ls..Ettph.hshpsplp.ps.......hhYttDacL.GDhVshtsp.h....Ghphsshlspl.........ppphc..psGh..plpspaGp........................	0	10	23	25
+14446	PF14595	Thioredoxin_9		Thioredoxin	Eberhardt R	re3	Jackhmmer:Q9I4A4	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.63	0.71	-4.58	80	573	2012-10-03 14:45:55	2012-01-20 08:05:38	1	3	547	1	117	2556	1082	127.40	35	70.61	NEW	Ghshs-alp.........phsp..........spc.chpclhcphplsp-tpp...hhpthspsh.phLllsEsWCGDuhhslPllp+lu.chs..slcl+llhRDcsh-lh....-paLT..ssu+uIPhhlhhD..........ps.hp.l.shWGPRPptlpc.hh..........sph+	...............................................................shspalsthpt..........Nppph.h..plYps....ap...lsp....-..p....hhch..h..p.t....s..h..+.l.L.V..l..o...E...sWCGDAhhsl.....Pll....c....+I.u...E....s....t..........Nl...-...l...+l..h....t..R...D......-..s.p..c..L.h..............DQYLT....sspu.....R.....u......IPl.F.lFls...........cp...hcp..ss.W....GP....R.ssclpc.hl.pph.t.................................................	0	40	85	105
+14447	PF14596	STAT6_C		STAT6 C-terminal	Eberhardt R	re3	Jackhmmer:P42226	Family	This family represents the C-terminus of mammalian STAT6 (Signal transducer and activator of transcription 6), it contains an LXXLL motif which binds to NCOA1 (Nuclear receptor coactivator 1) [1].	25.00	25.00	26.20	25.30	24.00	21.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.35	0.71	-4.37	2	54	2012-01-20 10:05:42	2012-01-20 10:05:42	1	5	26	1	17	45	0	168.10	78	23.30	NEW	PLPTPE.phPTMVPSYDLGMAsDoSM..QLusDMs...YPPpSHSI.saQsLs.EESlsVLsAFQE.PHLQMPPshuQMSLPFDQPHPQGLL.CQsQEHAVSSP-PLLCsDVsMsEDSCLoQPVsuFPQuTWlG..........EDhFPPLLPPTEQDLTKLLLEGQGEuGGGSLGAQPLLQPS.YGQsGISMSHhDLRsNPSW	....PLPTPE.QMPTMVPSYDLGMAPDS..SMsMQLuPDMVs..QVYPP..HSHSIss.YQuLs.EESVsVLsAFQE.PH.....LQ...MPP.....sLuQhoLPFDQPHPQGLLPCQPQEHAVSSP-PLLCSDVTMsEDSCLoQPVsuFPQGTWlG..........EDhFPPLLPPTEQDLTKLLLEGQGEoGGGSLGsQPLLQPSpYGQSGIS.MSHhDLRsNPSW......................	0	1	1	2
+14448	PF14597	Lactamase_B_5		Metallo-beta-lactamase superfamily	Coggill P	pcc	CATH:2p97A00	Domain	This is a small family of putative metal-dependent hydrolases.	28.40	28.40	28.80	28.70	28.30	28.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.30	0.71	-4.92	4	14	2012-10-02 15:46:01	2012-01-20 10:58:09	1	2	14	2	5	21	24	190.30	39	92.85	NEW	MKSLHRPDLYSWSsFNPARNIDFNGFAWIRPEGNILIDPVALSNHDWpHLESLGGVVWIVLTNSDHVRSAKEIADQTYAKIAGPVAEKEpFPIhCDRWLSDGDELVPGLKVlELpGSKTPGELALLLEETTLITGDLVRAa+AGuLplLPDEKLhN+pcsVASVRRLAuLEKVEAVLVGDGWSVFRDGRDRLcELVATL	.........................................................................RPDLasWShFs.t+NlDFNuhhhhRP-GNlLIDPlsLSscDhp+LpulGGlsaIVLT..NsDHlRuAcchAcphtA+lhuP.......su-.......c....cph.....PlssD+hLsDG-..pllsGlpVlpLp..GpKTPGElALL.L.--..s.sL.IoGD.Llhuh.uGsLshLPDcKhhshpcshtSl+RLAth..ch-slLsGDGWslh...pcupttLtpLh....................	0	0	2	5
+14449	PF14598	PAS_11		PAS domain	Eberhardt R	re3	Jackhmmer:P70365	Domain	This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6) [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.09	0.72	-4.11	22	2159	2012-10-04 01:10:46	2012-01-20 11:08:31	1	50	589	39	703	2822	16	106.50	29	13.98	NEW	p-pFoo+hshsGKIlplDpsslphsh.tahp.c-.lhspshaphhH.pDhp...hpp+h+phhp..........pGp.s..tSsh..YRlphpss..salhlpTpuplhp..sppssp.phlhssppllsEpps	.......................................h..pFhoRHsh..s..sphtalDp.+...s.............s..shl..GYhP..p-..L.l.G..p.s...hh.c..a.aHscDhp....lp..c.sac..p..lhp....................................pGp..s.....po..s.........Y..Rhhs+sG..salh.lc...............Tphpshh......Nsh.op..c.......c.a.llspppll.....t...............................................	0	147	210	422
+14450	PF14599	zinc_ribbon_6		Zinc-ribbon	Coggill P	pcc	CATH:2k2dA00	Domain	This is a typical zinc-ribbon finger, with each pair of zinc-ligands coming from more-or-less either side of two knuckles. It is found in eukaryotes.	27.00	27.00	28.00	28.00	26.30	26.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.45	0.72	-4.18	75	401	2012-01-23 11:24:43	2012-01-23 11:24:43	1	18	217	1	260	390	11	59.80	44	12.44	NEW	lsDMsphachLDpEItspP...MPppYpsphshIlCNDCss.pSpVpaHhlGhKCsp..C...sSYNTpp	.............h.hDMsthactLDtpluspP........MPp-Ypsp..pshILCNDCs..........s.cS.p.V.p....FHhLGh.KCtt..CtSYNTpp...............	0	67	148	216
+14451	PF14600	CBM_5_12_2		Cellulose-binding domain	Coggill P	pcc	CATH:1aiwA00	Domain	This C-terminal domain belongs to the CAZy family of carbohydrate-binding domains that are associated with glycosyl-hydrolases. It is suggested to bind cellulose.	27.00	27.00	27.30	28.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.12	0.72	-4.34	5	106	2012-10-03 03:17:01	2012-01-23 14:37:49	1	26	74	1	33	110	1	59.30	49	6.53	NEW	TssCANsNVYPNWVSKDWAGGQPTHNEAGQSIVYKGNLYTANWYToSVPGSDSSWTLVGSCN	.......................sss.lN...sYPsWsppDatu.ssoHAssGDpMla..puslYpANWWTsShPGSDuSWohlh...s....	0	2	22	27
+14452	PF14601	TFX_C		DNA_binding protein, TFX, C-term	Coggill P	pcc	CATH:1nr3A00	Domain	This is the C-terminal region of TFX-like DNA-binding proteins.	27.00	27.00	30.10	29.60	22.70	19.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.49	0.72	-4.19	28	73	2012-01-23 14:39:50	2012-01-23 14:39:50	1	3	69	1	53	84	0	82.70	30	56.08	NEW	ARETLpFhpsLsAPlplslcpGTDla-lPchlaspuDcsGlKVpasoh-Lhphlp-sAs-tlcsRhl+cchhlhlspcG-lplp	..A+pTLthacplpAPlplplctGTDla-lPchlaccuDctGlKVpYsohplhphlp-pAsphlcsRhlccshhlhlspsGclpl.........................	0	9	29	42
+14453	PF14602	Hexapep_2		Hexapeptide repeat of succinyl-transferase	Coggill P	pcc	CATH:2rijA03	Repeat	\N	27.00	11.00	27.00	11.00	26.90	10.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.50	0.72	-4.39	86	8656	2012-10-02 11:29:45	2012-01-23 15:54:45	1	152	4074	116	1925	24566	14688	33.80	33	14.21	NEW	sltIGcsChlGAN.us..l..G..lslGDssllsAGlhlos	.......................................lhItcss.h..I....G......u......p..uh......l..............G..............l......p.....lG-......ss.ll.u......sGshls.......................................	0	584	1174	1585
+14454	PF14603	hSH3		Helically-extended SH3 domain	Coggill P	pcc	CATH:1ri9A00	Domain	This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent.  It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides [1]. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered [2]. The binding partners of the hSH3 domains are still unknown [2].	25.70	25.70	25.90	25.80	25.20	25.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.95	0.72	-3.97	3	112	2012-10-02 18:48:24	2012-01-24 09:38:00	1	4	35	1	63	125	0	81.50	52	13.02	NEW	FRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND	.....FRKKFKa..-GEIpVlhpshlsss.hso++hGs+DLsI+sGEtLEVIp..hT-..c..sclLCRNpcGKYGYV.RotLh..-...s-lYDDl....................................................	0	4	9	20
+14455	PF14604	SH3_9		Variant SH3 domain	Coggill P	pcc	Jackhmmer, JCSG:target_422527	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.26	0.72	-4.38	37	9839	2012-10-02 18:48:24	2012-01-24 16:52:14	1	624	319	119	5343	17510	50	51.00	31	8.53	NEW	Alasap.sps..p.s..E..LplptG-hlhl..h..pp.....t..p...ssW.hh.u..p....h..sG..ppGhhPssYlp	......................Alasap..u....ps........s...c.......E......Lsh.p.t...G.-..l.ltl...l...pp...................s...-.....cGW..ap.G....p..................h.....sG........pp..G..h.FPusYVp............	0	1250	1872	3407
+14456	PF14605	Nup35_RRM_2		Nup53/35/40-type RNA recognition motif	Coggill P	pcc	Jackhmmer, JCSG:target_422743	Domain	\N	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.33	0.72	-4.19	21	98	2012-10-02 20:46:34	2012-01-24 17:02:17	1	12	56	0	66	283	2	55.80	26	9.42	NEW	spWlsVoGat..hcpt....thVhc.....aFp.s.hGpIlc...pphs................tsshhYlpYtsphssptAL	..................phlsVsG..as..scpt.....phlLp.....HFp.s.hGcIsc........hpls.........................tppshhhlpatschsA-pAl.....................................	0	23	29	47
+14457	PF14606	Lipase_GDSL_3		GDSL-like Lipase/Acylhydrolase family	Coggill P	pcc	Jackhmmer, JCSG:target_416889	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.03	0.71	-4.54	20	244	2012-10-02 11:02:24	2012-01-24 17:22:51	1	7	172	2	67	573	133	161.20	31	41.20	NEW	cK.PlVhYGTSIsQGAsASRPGMuaTsILuR+hstsllNLGFSGNu+hEsEls-llu-l.DA.ulallDslPN..........h....ospplpcRhtshV+tLRstHPcTPIlllEchh.hsps.hhcpptpcchpppspslpcsacp.LppcGsKslYalsucsh.lGpDuEuolDGsHPoDLGhhRaActaptll+	.................................................................................p.hlhYGoSIo.QGus....A..o+....P......u.....h.sasslhu......R.....p.....h.......s............h.....c.......l.......l.......NLG.....FSG...s..u....h....L........-.......................h..A...c.h.....l..s....-.....h...c.....A...clhs.....l....-.hhsN...................h....ssc...thppphpsFlcplRptH..P....sT.Pll...llps.hh..h.tt.....h..pt........................t.t......t....tt.p..t..hhtphhtt....h...t......t....t..sl..h....h..l...t...t...t...p......h.....s.......s............t....h......h.....s.....D....h.h.H.sshGh.hhup.h............................................................................	0	27	58	67
+14458	PF14607	GxDLY		N-terminus of Esterase_SGNH_hydro-type	Coggill P	pcc	Jackhmmer, JCSG_target_416889	Domain	This domain lies upstream of SGNH hydrolase, but its function is not known. There is a highly conserved GxDLY sequence-motif.	27.00	27.00	51.80	44.00	25.90	24.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.84	0.71	-4.73	44	142	2012-01-24 17:32:33	2012-01-24 17:32:33	1	6	85	0	28	136	91	147.60	34	36.76	NEW	sphpahsstph...sltG+uh.ssp..shYpRLPsptpst...lptsVhsLuppSAGlslpFpTsSspIps+aplsss.hshspMsssussGlDLYsts..sGpWpasus.up.sht....s.stshlhpshss......pt+EahLYLPLYsslpsLEIGlspsuplp	...........t.phpahsspph....slhG+uhtsp...shYcRlPsshpsh....sptslhpLu+sSAGlAlpF+oNSspIpl+apltss..hphsHMsssuhpGlDLYshp..sGpWpasss.up.sst....s..spshlhpshps......pt+EahLYLPLYsslpoLcIGVsssApl.p.................	0	16	27	28
+14459	PF14608	zf-CCCH_2		Zinc finger C-x8-C-x5-C-x3-H type	Wood V, Coggill P	pcc	Pfam-B_880 (release 26.0)	Domain	This is a zinc-finger of the type C-x8-C-x5-C-x3-H.	27.00	8.00	27.00	8.00	26.90	7.90	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.79	0.73	-6.70	0.73	-3.78	44	1117	2012-10-01 21:35:20	2012-01-26 16:52:10	1	44	235	0	664	1211	11	18.40	40	10.59	NEW	.C+.hhss.Cp.s.cChatHP	..........C+.ah..ss..Cpp.s..cChFtHP..	0	185	320	526
+14460	PF14609	GCP5-Mod21		gamma-Tubulin ring complex non-core subunit mod21 	Wood V, Coggill P	pcc	Pfam-B_276835 (release 26.0)	Family	GCP5-Mod21 is a non-core subunit of the larger gamma-tubulin ring complex that effects microtubule nucleation from both centrosomal and non-centrosomal sites. This subunit, unlike GCP2 and and GCP3 and others, is not thought to be essential for viability in the fission yeast, and may not be expressed in very high concentrations.  Fission yeast can form a large gamma-Tubulin complex C similar to that found in higher eukaryotes and this complex is important for maintaining normal levels of microtubule nucleation in vivo [1].	27.00	27.00	28.80	27.90	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	653	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-13.14	0.70	-6.41	4	5	2012-10-02 13:20:28	2012-01-31 09:18:48	1	2	3	0	4	28	0	519.00	25	90.96	NEW	VhsplEuls-K.phpshps.ANshcs+h--.lDR..VpsustsS.LHhpILHhLLEhSssPocss..KpPs.KclNsslEpEA.hspDsp.hpp.spGD+WD..ls-WSp......VTcsEEoEp.ss-NEchs-susaPcIPs..+hcNapp.chhhlFccpuQplhD+h.EKc..........lhRIuEQshhtE.oIhhLhG..............plLchlP....h.csLph.Ippo.LhchpsaG+sh-lhN.QVAsp+pCphahsDss...........DpEKpEsFls.hhlhQphTPphpuhlK....cLL.L.TpVRKht..Ihp...LptsspH.pKF......FR.AalchuppVhDhLpohhFIahpRhpN...........SLhhuthhpphYtEuh.Is.lhhpllsls+.TssasIuo.hLsILhpp..s.hpthcSlL.-aS..FLhKcCh..........ASQt.sFhhlV.sas.phsNhpp-pEshIcpslshpss..lsshc.uLsL.a-l.............ppaosRF.sL.pt.-EsacpLspKhFuKhlhtc.salsT.+salhp.ppcFTc.-plu.F.GVats..p-lssppVhtE.EK.....hlLKp+pKpLhsFhhsRstsL.su-hsshHK-.LtslM-......NsYKTplup.ID.pRhV....Dsp.shhlupluDllhc.up.lhscshpa+SsLs-tIhpshs	....Vh-pIEulsDKhphpshps.ANshcs+h--.lDR..VpsustsS.LHhpILHhLLEhSssPo......css.........KpPs.KclNsslEpEA.hs.pD.s.p.hp..p..spGD+..WD...ls-W...Sp...........VTc..s..EEoEp..s...s-...NEchs-su.sa..P.c.IPs..+hcNa.pp.ch.h......hlFc..c..puQplhD+h..EKc..........lhR.....Iu.....EQshhtE.oIhhLhG..............pl..LchlP....h.csLph.Ippo.LhchpsaG+sh-lhN.QVAsp+p.....C.....phahsDss...........DpEKpEs.Fls.hhlhQphTPphpu..hlK....cLL.L.TpVRKht..Ihp...LptsspH.pKF......FR.AalchuppVhDhLpohhFIahpRhpN...........SLhhuthhpphYtEuh.Is.lhhpllsls+.TssasIuo.hLsILhpp..s.hpthcSlL.-aS..FLhKcCh..........ASQt.sFhhlV.sas.phsNhpp-pEshIcpslshpss..lsshc.uLsL.a-l.............ppaosRF.sL.pt.-EsacpLspKhFuKhlhtc.salsT.+salhp.ppcFTc.-plu.F.GVats..p-lssppVhtE.EK.....hlLKp+pKpLhsFhhsRstsL.su-hsshHK-.LtslM-......NsYKTplup.ID.pRhV....Dsp.shhlupluDllhc.up.lhscshpa+SsLs-tIhpshs........................................................................	0	2	2	4
+14461	PF14610	DUF4448	GPI-anchored_2;	Protein of unknown function (DUF4448)	Wood V, Coggill P	pcc	Pfam-B_5686 (release 26.0)	Family	This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, Pfam:PF10342.	27.00	27.00	27.10	27.30	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.44	0.71	-4.81	53	151	2012-10-04 12:14:07	2012-02-01 17:11:59	1	2	119	0	114	146	0	188.40	21	49.05	NEW	ssstsusss...hhtCsspph..........ttPFCtPccssclhsspTYa.lTWsspaF............tp..VplplsYssssstpt..........................................................sha...sS-h..lsNspGaaslplcppWL........psp.h.........sslolp..thsstssh..s.h..........pGPpVtltsp.s....ph.s...t...pt..........................hlhlulPsslsh..hhlhhhhhhhh.p+cpRclu	............................t.ssh.tCpspph............tP.FCtPpcsspltsspTYa......lTW.spaF..........ssss..Vpltlsahppstspt........................................................tha...soch....lssst.GhhslplpppWl...........psp...........sslol.p.h.thss.ssh..ssh...........................pGsplhhssp.sh...thts...t..st...................................hlhlulPlslss..hhlhhhhhhhh.p+.cpRch................................	0	30	66	99
+14462	PF14611	SLS		Mitochondrial inner-membrane-bound regulator	Wood V, Coggill P	pcc	Pfam-B_1679 (release 26.00	Family	SLS is a fungal domain found bound to the mitochondrial inner-membrane [1]. It reacts physically with fungal Kar2p to promote translocation across the endoplasmic-reticulum membrane. This action appeared to be mediated via the promotion of the Sec63p-mediated activation of Kar2p's ATPase activity. This indicates that the Sls1p protein is a GrpE-like protein in the endoplasmic reticulum. In S.cerevisiae the SLS1 gene (ScSLS1) is not essential but is also involved in ERAD and folding [2,3].	33.70	33.70	33.80	34.20	33.60	33.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.24	0.70	-11.20	0.70	-4.91	34	140	2012-02-02 14:41:00	2012-02-02 14:41:00	1	3	113	0	84	142	0	207.30	21	25.97	NEW	sKptLsc+Ilc-sWpLslpscl........Gplplplp......sp.hslLhhspphhlppl.....hpppss+Iclppphs.hlcIouscpssphlpptlpchhsclcppplsls.h..h..t.pt...........hpsthLphlpphtpshhchssssp.hhhhhht................tsppps-pscRhLhhAl.s.pspsppshhss.hs..tst.h.h.sh..........pslsWhsRp.cpWhRWt	...sKttluttIlcchWpLplpcp..lp............Gch.....lplp.................st.htLLhsp....sp.h.Lcsl..........................st.tt+lsspppps.tlpIpu.scushphlhpplsclhpslpopplslp.h.....t.pt...............p.....hs.pthL.splsphosshhcpsss..sst...lp..lpaht..................tsccss-hshRhLhhAh.s.tsp.ss.p.phhsphhs.............pstpuphhshss........................cshsWh-+..+pWhRah......................	0	13	41	71
+14463	PF14612	Ino80_Iec3		IEC3 subunit of the Ino80 complex, chromatin re-modelling	Wood V, Coggill P	pcc	Pfam-B_3771 (release 26.0)	Family	This is a family of fungal chromatin re-modelling proteins found in one of the chromatin-central complexes, Ino80. The function was identified in Schizosaccharomyces pombe but there is no orthologue in S. cerevisiae. 	27.00	27.00	39.30	36.80	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.57	0.70	-4.30	22	99	2012-02-03 15:55:25	2012-02-03 15:55:25	1	3	72	0	83	95	0	161.80	30	59.05	NEW	Y+SaKKKYtKh+IpF-.tM+-S-uLh+EEh+hp-huKRlpEQNDQLL-lLLEhNsSh+lPschRac...Luh..Pss..s.hhss..t...s...s.thhpt.Lp.u+sph.sGphp.pthp.lttshhpspsh.sPsh.phssLlp.VPHos.sstppp.....sDh-h.......sp.....shGFLoPEc-sEYhhshDu+lus.s...t.tphsp......pPshu.............p.-R-hslRNPsSVYNWLR+ppPplFLQDsE	.....................................................................................+Sa++KatK.+lhF-.tM+csptLh+p-.+h.shs+Rlt.pND...............pLL-hLL-hNpo.pls.phRhslsh..ssp.............................................................ts.h.phtpL.p.hPH.t.............p.p...................t..........s.sahss-c..pYhhthD.ths.................................t...t........................................ppph.l+NPsSVhNWLR+ptPp.hFLpDt-...........................	0	15	41	68
+14464	PF14613	DUF4449		Protein of unknown function (DUF4449)	Wood V, Coggill P	pcc	Pfam-B_1378 (release 26.0)	Family	This is a fungal DUF of unknown function.	27.00	27.00	27.10	27.10	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.83	0.71	-4.32	28	110	2012-02-03 16:32:29	2012-02-03 16:32:29	1	2	90	0	89	117	0	152.00	33	17.97	NEW	sVclcsLcIKlKKSpHKlLF.slFKPlLhpl..lRPulpKslEppIR-shp+sDuhhacl+pEAcRut-tucp..DPpp.ssNIYs+YhsAhpcchtpt+.cKAptt...ss....DpKlphAhTpc-SlFscIpLPGG..ISoKATEY+-........LAc+G-+.WESPlFoIGsAucSsslPp	.....VclcsLclKl+cSpHKlLF.slFKPlhhpl..lRsslpKslEctI+sshpphD.t.hhapl+pEAc+A...tctucp..sPpp....t.shascYhsAhppphhpt+.pcupth...ht....................-pclphshopccSlF.plpLPGG.....lSsKATEYc-........LAt+.....G-+...WcSPlFuIGpAtpSpslP.........................................................................	0	35	55	76
+14465	PF14614	DUF4450		Domain of unknown function (DUF4450)	Coggill P	pcc	JCSG:Target_393004-GS13576A	Family	This is a family of bacterial proteins of unknown function.	27.00	27.00	30.00	27.50	26.80	25.90	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.43	0.70	-5.19	8	86	2012-02-06 10:27:07	2012-02-06 10:27:07	1	3	47	4	14	68	0	154.60	27	20.87	NEW	MPshuGohRhGlssGscSpWlc-.hpKhcupa.hssp.hhhhps.......plplslhuLuDocGFIlElcucclP.-slsLhWuFGGssut....hscDsDIsu-st.......t.ChcNlaolcpssFTlhY.G.cuh......pL+s.......lsGlhPsto-IRLuDuctpsoPLpLapStKKossPVluu+hslsspp.........shYFshYp.psu+A-Ysha.hLspLFpKpcp	......................uGshphtl.pus.p.o.hhLcs.tpphcupahst+h.Y.l.c..h.ttGplpltshAhsDscGhIhchpsp....shs.c.ushLhWtaGsspst..phspsuDhss..p.......................................................................................................................................................................p.......................................................	0	6	14	14
+14466	PF14615	Rsa3		Ribosome-assembly protein 3	Wood V, Coggill P	pcc	Pfam-B_11864 (release 26.0)	Family	This is a family of 60S ribosome-assembly proteins, from fungi.	27.00	27.00	27.90	28.30	25.70	26.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-8.10	0.72	-4.67	29	100	2012-02-06 14:52:56	2012-02-06 14:52:56	1	3	96	0	77	91	0	47.10	37	24.20	NEW	phpshYLphhsppFu-DL-pLR.pusDF.sspoLshLsps.LcpGsshFs	..phpshYLphhsppFu-DL-clR.pssDF.ss...coLslLscu.LppGsshFs..	0	28	52	71
+14467	PF14616	DUF4451		Domain of unknown function (DUF4451)	Wood V, Coggill P	pcc	Pfam-B_5126 (release 26.0)	Family	This is family of fungal proteins up-regulated during meiosis.	27.00	27.00	27.60	28.90	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.22	0.71	-4.37	35	127	2012-02-06 15:39:06	2012-02-06 15:39:06	1	3	102	0	103	133	0	115.60	36	20.33	NEW	spsht.sDhYpPcalRspssp+.........pGhCshCt.........phhahshKsSuYh.aHhshpHGIsu.sGhhhssPpthtphp..p..............................cthp...............thpuhCt..pCpc....hlslps........t+...p.hhsaa+Htpc.pH	..........p..phpsDhYoP+alRspusc+...................EGhCshCc.........sscWLsLKNSuah.YchuasHGIou.sGps...att.Ppph+chp..........................................tpsp...................hh-GlCs..sCpc....Wlslss........sp...pthhsaaRHshcsH..................	0	37	66	92
+14468	PF14617	CMS1		U3-containing 90S pre-ribosomal complex subunit	Wood V, Coggill P	pcc	Pfam-B_3046 (release 26.0)	Family	This is a family of fungal and plant CMS1-like proteins. The family has similarity to the DEAD-box helicases. 	35.00	35.00	36.50	35.30	34.90	34.50	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.56	0.70	-5.31	5	248	2012-10-05 12:31:09	2012-02-06 17:00:37	1	7	211	0	174	236	2	221.00	27	77.70	NEW	TToscRKRpup....pcpuGKKcK.pt.........+RpK+ccRKcu-Lhpht.DVcuG....LNpAhA+MsPcLLADYlAsplKRFtoDLSSVELED+YIsASAIpDTTSFTKPRTLDNLP-F.LEcFSchssKLspusKoNGSPHTLlLTuAALRAADLuRulRKaQ...TKsscVAKLFAKHIKLcEpIoaLKsSRlGIAVGTPsRItDLl.-sESLoVDpLK+IVlDASalDpKsRGILDh+ETpcslhc.lLGpKplp-Rac..-cKlcVlFY	........................................................................................................................................ttpt.......................tp......................tptp.t..........p......t...th..........p...t.................t..p...........psp....h..-hh.tph.h.p..............t......h.......p.h.osl...ELp-h.............ls...........p.ss..h....h.......sssph..p........p.t...h.cs..l..ssa..l.c..t...h....s.......t..................p........l...........pt...p.....p...p...toPh......hlllssuulRus-lh.Rulpsap......stssplhKLFAKHhKlcE.........plph.L...............c.....p.....p.......p....sp....lulGTPsR............lpcLl...c.....p........s..uL..p..l..s..pLchlVlDhsahDpKtpslhDh.-h..p..lhc.hLt........................h..............................................................	0	52	92	139
+14469	PF14618	DUF4452		Domain of unknown function (DUF4452)	Wood V, Coggill P	pcc	Pfam-B_6056 (release 26.0)	Family	This fungal family has no known function. However, it is rich in paired, as CXXC, cysteines and histidines, but these do not fall in the conformation that might suggest zinc-binding.	27.00	27.00	49.30	44.50	25.00	23.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.15	0.71	-4.43	14	83	2012-02-06 17:08:27	2012-02-06 17:08:27	1	2	81	0	67	81	2	156.30	44	82.24	NEW	sHH....GGRsRRus+hSuupssp+QFR.GV+SM+-L.sEusulsuFRtRFEAuRSFDLEDDhEFCP.sLLTEsDLsSIpS.tuS-RSSLuSsSPpuSPtQp..ps.....ssuhSLsuuussh.sPsh.......pp..sthKlHQPuAsRsRNAIPIVNPsTGhshoSPPsSlsP.t.M........htRRW	....................................pt...ssRsRRss+huspps.p+QFR.....GV+SM+-L..sEusuloAFRsRFEAGRSFDL-DDhEFCP.sLLTEcDL.................pSIpS...tuS-RSSLuSsSP-oSPhQp.hps.....ssuhSLssu..o.ss.h.hsssh......pt....sth+lpQP.oAsRs.RN.A..IPIVNPsTG....hploSP.Ps....ShpP..................................	0	9	32	54
+14470	PF14619	SnAC		Snf2-ATP coupling, chromatin remodelling complex	Wood V, Coggill P	pcc	Pfam-B_4045 (release 26.0)	Domain	This domain appears to play a crucial role in chromatin remodelling for yeast SWI/SNF. It binds histones. It is required for mobilising nucleosomes and lies within the catalytic subunit of the yeast SWI/SNF. It is found to be universally conserved [1].	27.00	27.00	29.30	29.30	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.65	0.72	-3.81	109	470	2012-02-07 11:49:24	2012-02-07 11:49:24	1	26	242	0	281	441	0	79.00	40	5.41	NEW	pE....Rppp..ct.................................t.hs.RLhp-sELP-hhhp-tsth..............hpt-pptt.......GRGsRc.RK......p.VpYs.DuLT....E...-Q......WL	.............................................................................................................h.-Rc+c-t......t.........................scphP.RLMpE-ELPshhhcDcscl..............hppE--Ept......GRGuRp.RK......c.VcYs.DuLT...EcQWL...............	0	80	142	228
+14471	PF14620	YPEB		YpeB sporulation	Coggill P	pcc	Pfam-B_309 (release 26.0)	Family	YPEB is a protein that is necessary for the functioning of SleB during spore-cortex hydrolysis.	27.00	27.00	27.10	27.20	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.90	0.70	-5.44	62	303	2012-10-01 23:09:26	2012-02-07 14:26:29	1	9	272	0	84	258	0	334.50	35	74.40	NEW	hll.ssuhWGapppp.......c+sshphthpNpYQRAFa-LstpV-plcspLuKslsssSppptt...hhs-lWRhuutApssluQLPlsths...hscTpcFLuplGDFuYplut+shssp.sLocc-apsLppLappusplpppLpclpppl..hpsplc.Wh-.............lctth......ss..phppss........................sshlsstFpsl-cpl.ppYP.sl.a-GPh...S-ph.pcpsP+tlsG..plopc-ApphAppalshp.p.tphpsspssptsphssYshplts.tpptt...hhh-lo+pGG+llahlss..Rslu.........psp.lshscAhppAppFLpptGa..psMpss.stph.-........NhushsF..s.hppssVhlYPDhlKV+VALDsGcllGa-ApsYLhsHpp.Rsls	...................................................................h.llusuhWGYppap.......E+sslhhts-NpYQRAFa-LshpV-.LcsplupolshsSppphs..ssLs-lWRhoupApssluQLPls.hs...hscTpcFLuplGDFoYphuh+shptc.sLscpEacsLppLappusplpppLpclpphl..hpssL+WhD...........................lchshus...ptp.sc.........................ssllsu.hcsl-+sl.psYs..shta.GPh.......Ssph.pcpsshthpG..+tISc--AtcIAcpFlshp.......t.....s.....p......plp.l.p....p.....us.psuph.shYolplpstsppst.....hhh-lotKGGaslahh..ss......Rpl.p.............cp+.lSls-Ats+uhpFLcc...pta..psMphhpoppaD..............Nlulaoa..V..s.s..pssVhlYP-tIphKlALDsGpIlGFsApcYLhsHpc.RslP.............................................................	0	35	63	71
+14472	PF14621	RFX5_DNA_bdg		RFX5 DNA-binding domain	Coggill P	pcc	Pfam-B_20855 (release 26.0)	Domain	RFX5 and RFXAP reveals molecular details associated with MHCII gene expression.	27.00	27.00	119.70	119.70	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.45	0.70	-4.73	7	47	2012-02-07 16:00:39	2012-02-07 16:00:39	1	2	30	0	16	42	0	211.40	75	35.26	NEW	PGPGpAPPGGLTQPpGTEsREVGIG.GD.GPHDKGVKRTAEVPVSEASGQDPPAKAsKQ-hEDTuSDAKRKRGRPRKKSGGSGERNSTP-KSAAAh-SuQSSRLPhEsWuSutEus..uuuGsERPGssGEAEKGsVLsQGQtDGAVSKGGRGPuSRHAKEAEDKIPLVssKVSVIKGSRSQKEALpLVKuEs-susQGsKDLKGHsLQoSLs+E+KDPKAs	....PGPGRAPPGGLTQPRGTE.NREVGIG.GDPGPHDKGVKRTAEVPVSEASGQDPPAKAAKQDlEDT.uSDAKRKRGRPRKKSGGSGERNSTPpKSA..AAh-SAQSuRLPWETWGSGGEuN..SAGGuERPGPhGEAEKGsVLAQGQpDGsVSKG.GRGPSSpHsKEAEDKIPLVsSKVSVIKGSRSQKEAh..LsKGEs-TAsQGNKDLKtHVLQuSLopE+KDPKAT.	0	1	1	2
+14473	PF14622	Ribonucleas_3_3		Ribonuclease-III-like	Wood V, Coggill P	pcc	Pfam-B_6419 (release 26.0)	Family	Members of this family are involved in rDNA transcription and rRNA processing. They probably also cleave a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; they are involved in polyadenylation-independent transcription termination. Some members may be mitochondrial ribosomal protein subunit L15, others may be 60S ribosomal protein L3.	35.00	35.00	35.10	35.00	34.90	34.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.63	0.71	-4.18	70	4780	2012-10-03 08:45:47	2012-02-07 16:33:03	1	23	4550	5	1167	4144	2037	128.80	40	47.56	NEW	cppLLppALTHpSa....s....p.....t....p..p....p....p....NERLEFLGDAV...Lp..L....s.....s.oc..........a.l.a.cp............h.s.h..s..E.G.t.........h.s+hR.A.s...lVs.cp........oL.AphA.+clp..........LucalhL.....t+GEtt.psupsc..cs..ILuDshEAllGAIYLDtGhpsApcFl...tch...llssl	..............................................pLLppALTH.p.S..h...........s...............................t....t....t.................p.......p.........NER....LEFLGDuV...Ls.l.....l............l.u.c........................h.L...a.cc............................s.t...s...E...G.c.................................L.o+hR..A..s....l.Vp.pp..................oL...Ap..lA.+.chs...................................................Luch.lhL........................GpG...E.tp.....oG.G.p....c.+......sS............I.Lu..DshEAllGA.laL....D...p...G......h..p..s..scphlhphh....h.....................................................................................	0	402	757	987
+14474	PF14623	Vint		Hint-domain	Coggill P	pcc	Burglin T	Domain	This short domain is a conserved region of intein-containing proteins from lower eukaryotes	27.00	27.00	27.40	27.90	26.50	25.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.34	0.71	-4.75	14	51	2012-10-03 10:25:13	2012-02-08 11:39:37	1	9	47	0	42	56	43	164.60	36	22.29	NEW	sCFsGso.VpLuuscs.............l.........plcplRtG.pVhsPp....Gs..ccVtsVLpTsVpp..tplCcl...........G.sLhITPWHPl+h..tuc..WtFPsslu.....pscs......lYSlLL-ss.....HAlhV..sGhhsVTLGHGlpt.......pDltuHtaFGs.ppVs+sLttLsthtpG..hlhstuh..pRsst.TGhVpG	..................sCFsGps.Vplussps......................lplcpLRtGhpVhTPp....Gs..R+VtsVLpTsVpp...tslCpl...........................G..sLhlTPWHPlph..ssc...WhFPsshupt.s.h...sss........lYSVLLcssss...........spAHAlhV.....tsh.hsVTLGHGlps.........spDlRAHtFFGsYptVhcsL.tpLst.h...sG..llhstGh...Rs..oGhh................................................................	0	16	26	36
+14475	PF14624	Vwaint		VWA / Hh  protein intein-like	Buerglin T, Coggill P	pcc	Buerglin T	Domain	VWA-Hint proteins carry this conserved domain of around 300 residues, now named the Vwaint domain. Such proteins do not seem to have a signal peptide for secretion. Generally, this domain lies between the N-terminal VWA domain and the more C-terminal 'Vint'-type Hint domain. The exact function of this domain is not known.	23.50	23.50	23.60	23.50	22.20	23.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.82	0.72	-3.87	28	182	2012-02-08 15:26:40	2012-02-08 15:26:40	1	17	64	0	112	174	28	78.50	32	12.02	NEW	DptspuLhtDLpt...............QlphAhsspphYc+WG+pYLhSlhsAHshQhsssFKDsus..a.G..oshFppsp.............tphsshaDtLssPps	................D.hstuLhtELp............................chppth.....tsp.phYEppGRuYhLSuloSHuhQRs..su..Rs.Ds..........................os.h.hh.....................hphsshhc.l..sp..............................................	0	19	51	92
+14476	PF14625	Lustrin_cystein		Lustrin, cysteine-rich repeated domain	Coggill P	pcc	Jackhmmer:O44341	Domain	This repeated domain is found in proteins from lower eukaryotes in lustrin, perlucin, pearl nacre, and other similar protein-types. Each repeat lies between Kunitz-BPTI repeats, in certain species, which are also cysteine-rich. The cysteines may form the disulfide bonds observed for other members of this superfamily.	27.00	15.00	27.00	15.00	26.90	14.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.27	0.72	-3.88	56	1210	2012-02-08 16:11:41	2012-02-08 16:11:41	1	138	35	0	833	1225	0	45.60	27	22.43	NEW	ssCshG.pPhl.s.ssp.htC....sssss...CPssaaC.ahGss.ps.olCC.s	...............Cst.G..pshh.......t.ssp.shtC.....sspss......C.P.s.s..ah.C...p.....hu.ss.s...pp...sl....CCs...................	0	301	402	824
+14477	PF14626	RNase_Zc3h12a_2		Zc3h12a-like Ribonuclease NYN domain	Coggill P	pcc	Jackhmmer:O18125	Family	This family is found to be a divergent form of the NYN-domain- containing RNAse family.	21.00	21.00	23.80	22.00	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.66	0.71	-4.25	5	17	2012-10-03 20:43:45	2012-02-14 17:06:22	1	2	7	0	15	17	0	116.20	32	19.74	NEW	Y+ssLNLPVKALsDIIhhFLIRGHKTsVYLPKYY-Dalo-sGlSKVDDlVAFc................+Ll-LsaI..Kh..Ip.s.ca+WFNEVuchAD+sGAVFVSSsE.YRpRchclcYsKsSERIITPC.FLNA-DRLM	...............L.V+sLh-IllpFllcGHKTslaLPcaYpshhs...hpKVDDl.sFphLhsLchI+F...lpp...csccthhppVhtcA-+ssGlhVSssE.hhtp........................................................	0	5	6	15
+14478	PF14627	DUF4453		Domain of unknown function (DUF4453)	Coggill P	pcc	Jackhmmer:C9CWS7	Family	This short domain is found only on a small subgroup of proteins from Gram-negative Proteobacteria that also carry a YARHG domain, Pfam:PF13308. They carry three conserved tryptophan and three conserved cysteine residues.	26.10	26.10	26.10	98.00	25.30	22.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.46	0.72	-3.92	11	12	2012-02-14 17:36:03	2012-02-14 17:36:03	1	1	11	0	4	12	2	107.00	41	57.09	NEW	uC+VDTupppL..DlpDlthR.+pLhcLPlpD-hESAClGWhGsPlsLpAG+uh.soshIGpIpsGDslpauHhs..hGGWoYVola.ss.DWtlhouGWhc..hsths-pCspFAG	.uC+VsTppppL..slpDhthR.+pLhsLPlpD-hESAClGWhGsPlsLhAG+uh.soshIGpIpsGDsltauHhs..hGuWoYVosa.ss.DWtlhouGWhc..hsths-pCppFAG	0	0	4	4
+14479	PF14628	DUF4454		Domain of unknown function (DUF4454)	Coggill P	pcc	Jackhmmer:A8RR49	Family	This C-terminal domain is found only on a small subgroup of proteins from Gram-positive Clostridiales that also carry a YARHG domain, Pfam:PF13308.	25.00	25.00	97.50	97.40	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.49	0.70	-4.71	5	9	2012-02-14 17:48:16	2012-02-14 17:48:16	1	2	8	0	0	9	0	198.90	40	43.06	NEW	caDcs+uctt.KpGY-uLPPAPYLsLLsc+sEhGVpLYSDluHAsD+GlYYsAcGTISVPloITsEQYculLs-GuElclVlNELTGEo+hL++ss.so-YG-s...hLlY-tGsEP.pssGE-TGtYh.loY-PsSGsYoLWssSsDTVFKTVYcGsVYVLKGA.........sEEaYsYFshP-+upsE..o..u.RVMpFs-.sshGssGY.sGNpLsaDuKGYlKAIYaLGD	...phDcsphctt.phth-sL..APYLphLscasEhtlpLhuDhspAhDhGhYYsspGoISVPholTtEQhps.httGuplclshsELTGEpthLphs..sschsth...hhha..Gp-s.ts.G.-sG....loh-.pSGpYpLWpsSsDTlhKTVYcGslYlLKGA.........spphYshhshsscupsE..s..u.hs.phst.ts.G.psh.hGNpLhasu+GYhpAlYaLGD	0	0	0	0
+14480	PF14629	ORC4_C		Origin recognition complex (ORC) subunit 4 C-terminus	Eberhardt R	re3	Jackhmmer:O43929	Family	This entry represents the C-terminus of origin recognition complex subunit 4 [1,2].	25.30	25.30	26.10	27.40	24.50	25.20	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.26	0.71	-4.93	87	326	2012-02-17 08:55:20	2012-02-17 08:55:20	1	17	258	0	210	324	1	202.70	22	39.47	NEW	hclscphLt.lssp...............................................tpphhptWNptlpp....Lhpsp.phpphLpphatts.+sh.....pphhs.h...hh..sl..splsssps............hlsssphh..........thsph.hsc..................phph.lpuLSsL-LsLLlAhs+Ls.thh-..............shNFsh.sas.EYpphhpptphp............................................psas+slsh.........puaE+LlphsLlhs............................t.ssststt-h.phhplplshppl.pslppt	........................................................h.plhpphLp.Lssc...............................................sptahppWNpplpp....Lhpsp...phpphLpphaphs.psh.....pshhthl................hh.......sl....spls..s.pps...................hlsssshh........pssphhp.D....................schph.lpuLSsLELsLlIAhp+Ls..cha-.............tshNFph.sYs.Eapchhpptptp............................................phat+slsh.........cAaE+LhphtLlhs............................ttsssphth-h.phh+l.ls.pplhpslt..h..................................................................	0	68	114	172
+14481	PF14630	ORC5_C		Origin recognition complex (ORC) subunit 5 C-terminus	Eberhardt R	re3	Jackhmmer:O43913	Family	This entry represents the C-terminus of origin recognition complex subunit 5 [1].	25.00	25.00	30.80	27.80	23.80	23.00	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.78	0.70	-4.94	68	327	2012-02-17 09:01:59	2012-02-17 09:01:59	1	12	261	0	243	309	2	262.10	25	53.50	NEW	lhFPsYo+cEhlpILtps..........tss.h.....................p.s.plaspFlshlhcshhsss.pclsplppls..cphWspaspPltsG.ph.....s..................tp-hs+Lapphpshhpp...thpslh..spphsss.....p.t............................t.t...............ttht........s.ss..s.p.....hcLPhhuKaLLlAAYLASasPs+hDtphFu.Ktp..u.....+p++.........p.pp.t...........................................................p......pp....tc...h...........................ssp..h...L..uPpsFsLERLLAIapuIh.....................s.p.t....ss..................................sss-......lhspluTLssL+LLsps..u.u.....s.................ssLD.u..sKa+sN..........Vuh..........-hltplA+uluh-lscYLh	...............................................................................................lhFP.Yshtph.pIL.ts................s.............................................p.s.phaspalshlhsshhtss.ps.l.pLppls..thhaspa...sp....Plhpsph.....t......................................p-h...p.+Lhpp.hps.hhpp...thp....plh...p...t.h.sstp.t.................................................t........t..........................tphp.......shts.ttp.............hpLPhhuKalLlAAYLASaNss+hDtphFs.+tps......................+p++p..ttt......................................................t..tp...tp..h....................................spp..h...l...sPcsFsL-RLLAIa.uIh...................sp...ss........................................................sss...lhtpluoLhpLpLlshsus.....t................................................s.h-.s.s+a+ss..........lsh..........-hlttlu+..s..lshpltpal..........................................................................................	0	72	122	203
+14482	PF14631	FancD2		Fanconi anaemia protein FancD2 nuclease	Coggill P	pcc	Jackhmmer:Q9BXW9	Family	The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.	27.00	27.00	27.30	27.10	26.80	26.60	hmmbuild  -o /dev/null HMM SEED	1426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.09	0.69	-14.36	0.69	-7.47	4	248	2012-02-21 15:25:38	2012-02-21 15:25:38	1	8	108	1	170	249	6	667.60	19	82.83	NEW	MlSKR+hScs-scEs.TEDuSKTchpshStcoKKS+luccsp......EN-SVFVcLLKtSGlhLKsGEsQNplAVDQlhFQKKLhQsLRKHPuYPplIpEFlSGLESYIEDp-pFRNCLLsCp.hpsEpu.ohusSYscSLIKLLLGI-ILQPAlIphLFEKlPEFhFEstspDGlNhPRLIVNQLKWLDRlVDGKDLosKlMQhlSVAPVslQHDIITSLPEILtDSQHu-VuKELusLLhQNTpLTVPILDsLSSLcLDsshLuKVRQhVMspLSSV+LEDLPVllKFlLHSVoAsDulEVIu-LRcpL-LppCVLPupLQASQsKLKSKuhA.SSSssQpoSuQsClhLlFDVIKSAIRapKTISEAWlKAIENhsSsu-HKVlDLlhLhIIaSTNo.po+KtsE+VLRsKIRpGCIQEQLLQssFpsHhhVlKDhhPSILuLAQoLLHS.DpsllsFGShhYK.AFphFDoYCQQEVVGALVTHlCSGsEuEVDsALDVLhELVlLpPStMhh.AsFVKGILDYh-NloPQQIRKLFalLSTLAFSQ.pppuuHIQDDMHlVIRKQLSSTV.KYKhIGIIGAVTMsG.MAtcRscssu..pcpusLSpEpssQVooLLpLV+SCoEpSPpAuALYYDEhANLIQcpK..LDPpsL-WlG+olhpDFQDsFVVDhssss-GsF.FPVKuLYsL-E.-TQsGIAINLLPLhhppp.uKsusphoutpSppRhVSPLCLuPaFRLLRLCstcQHsGsLEEIDuLLsCPLaLTDLEssEKL-ShStpERpFhCSLlFhTlNWFREVVNAFCQQssPEMKGKVLTRLpsIsELQslLpKhLAsTPsYVPP.AsFDsEohDhhP.SsoslsAKttpKtKsG.+KpKuDuSKsSSuDphptEcsS-s-.ssochucl.sKctstKEs.KohlpLpsY+sFFRELDlEVFSlLHCGLlTKhILDTEMHTEAoEVVQLGPAELLFLLEDhspKLEphLTss.A+RlPFLKsKGs+slGFSHLpQRSspEIspCVspLLsPhCNHLENhHNaFQsLhsENpGVVDtsslslQE.plMuSCYQpLLQlhHsLFAWSGFSp.EppsLL+SALpVLusRLKpsE.ps.PLEELlSpSFpYLQNF+pSlPSFQCALhLhpLLMsl.EK.usssspp+EKlASLAKQFLCpsWs..uG-KEKuspaN-pLHsLLsIYLEHTDslLKAIEEIuGVGVPELlNusKDAsSSTaPTLoRpTFlVFFRVMMAELEKoVKpI.sGpsuDSQplppEKLLhWNhAVRDFpILINLlKVFDS+PVLpVCLKYGRLFVEAFLK.sMPLLDaSF+KHREDV.SLLcThQLsTR.LHHhCGHSKI+QDTtLTpHVPLLKKSLE.hVhRVKAMLsLNpCpEAFWLGsLKNRDLQGEEIlSQs..S...pEusAE.-SE-shpSpAucsc	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...............................................................................................................................................................................................................................	0	80	98	142
+14483	PF14632	SPT6_acidic		Acidic N-terminal SPT6	Wood V, Coggill P	pcc	pfam-B_9510 (release 26.0)	Family	The N-terminus of SPT6 is highly acidic. The full SPT6 protein is a transcription regulator, but the exact function of this acidic region is not certain.	23.30	23.30	23.40	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.86	0.72	-3.82	58	252	2012-02-21 15:38:02	2012-02-21 15:38:02	1	29	221	0	193	259	0	90.40	37	6.20	NEW	pDSSEE-.......----DEEEt+c......l+EGFIVD....-DE.......----p..pptp......c++++K++++cc+ctE--...tLDEDDL-LltENsGhttpp.........sKaKRLKRupc--	.................DuSEE-.......-p-DDE-ct.cp......................hcGFIsDp...-DE........E---t....pctt...........cpccc++++.++c.......+..........p.p.t--..........pLD-DDh-LItENhGsphcct........pKaKRLK+hpc-.......................	0	57	100	160
+14484	PF14633	SH2_2		SH2 domain	Wood V, Coggill P	pcc	pfam-B_9510 (release 26.0)	Domain	\N	27.00	27.00	31.50	27.10	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.36	0.70	-5.28	4	312	2012-10-01 22:44:06	2012-02-21 16:35:46	1	42	265	11	230	336	4	211.70	35	14.81	NEW	..+soYaDh-AEtcDscpEcc.pptpQRsphl+RVIsHP.F+slNh+QAEchhcoM-pGDlVIRPSSKG-sHLsVTWKVu-GlYQHlDVpE.tKENsFoLGpsLhls......opcapDLDEIlscYlQshAphhc-hhsHchF+c...Gs+KchEchL.chp+tpPsh.sYahshs+-hPGhFlLsapspups+lph..VplTPsGFhhpuplaPoVsuLhphFKshY	......................................................h......aD.ptE..t.t.D.p..c...p...cc.t.p.c.p.p.t.R......h.h.p.RVItHP.F+.shshppAEchLts...t...s..t..G-slIRPSSKGt.sHLslTWKVs....Du......laQ..H..lD..VtE..s..K.....-.....N....t.....a....olG+pLhl.s.......pppapDL.DEllscaVpsMuphlc-lhs.H.c+.a.pc...........Gs.+p..c....h..-..c..............hLpp.ppts.Psp.sYhh..sh..sp..c..hPG..h..FhLs.....ahs......ssp......s.+h..ph...VplhP..cGac..h....p.tp.........asslptLhp..hFKph......................................................................	0	79	131	193
+14485	PF14634	zf-RING_5		zinc-RING finger domain	Coggill P	pcc	Jackhmmer:Q495C1	Domain	\N	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.55	0.72	-4.23	118	801	2012-10-03 15:03:13	2012-02-21 16:43:03	1	78	214	0	571	6385	343	47.50	29	12.65	NEW	pCs..hChpth...............ppt....hhlssC.uHl.hCp..pChpptt.................ttpCPh..Cpp	....................................Cs..lChpph........................t.ppt............shlhs.C..uHs.hCp..pClpphh...........................ttphpCPh..Cc..................	0	166	222	455
+14486	PF14635	HHH_7		Helix-hairpin-helix motif\	\	   	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.25	0.72	-3.91	4	299	2012-10-03 02:11:09	2012-02-21 17:03:10	1	47	257	2	231	2357	68	104.10	41	6.91	NEW	-DlhsLphHPhQchlspEpLhpAL.stFlshVN.VGVDVN+AlspsYptullpYIsGLGPRKusalLKhLppsNsRL-sRoQLlThshMu.KVFhNCAGFlhIs	.................................c-IlsLph.H.P.hQp.h.ls...p-cLhptLcpthV..shVNt........VGVDlN..cAls.......c.sap.sslLpaVsGLGPRKAstLl.......K.......hl.p..p.s...s..stlp.......sRppL....ls.........h......s......hhGs..+VFhNCAuFLpIp...................................................	0	87	136	196
+14487	PF14636	FNIP_N		Folliculin-interacting protein N-terminus	Eberhardt R	re3	Jackhmmer:Q9P278	Family	This is the N-terminus of folliculin-interacting proteins [1,2].	25.00	25.00	25.70	29.30	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.96	0.71	-3.68	40	205	2012-02-22 08:14:46	2012-02-22 08:14:46	1	9	140	0	136	194	0	126.80	33	11.18	NEW	plRlllhQ-sptcspp..lLFDSpsspphspsssss.st..s.......................tsphspttt...hpssssp..............shttp.p....hpspsppsthpa.t+....ssDlshL.u-hlFGSss.MuY+G.oohKlHhls...us.sphhhopsh	.........................................plRlIlhQDsppcscp..lLFDSpshp+.spphs.spphs.sss....................................................sphsp........ssssp...............................puhpsosss......pscpptsc.aphsRs...usDsshL.uEMhFGSlA.MSYKG.SohKlHhlp...oP.splhhopl.......................................................................	0	27	49	88
+14488	PF14637	FNIP_M		Folliculin-interacting protein middle domain	Eberhardt R	re3	Jackhmmer:Q9P278	Family	This is the middle domain of folliculin-interacting proteins [1,2].	25.00	25.00	27.10	26.50	23.70	21.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.54	0.70	-4.78	17	166	2012-02-22 08:15:25	2012-02-22 08:15:25	1	9	87	0	101	150	0	226.90	48	22.26	NEW	ptsstssppsssht++t+lulullhpl...........s-sptpph......cpFhhpHhsllEochs+L+stlcp..............ushptptalphlhpAhpch.pphlssLaou........PRlppPVWLshho................sppppplspcFhppLspLlpphsp+popaFlSsLlTAVLTaHLuWVsTVtsssts..........p.hh.hp.ppplsplspsaPY.NsLWAQLuDLYGulG..............sPs+Lu+TlVsGspp...llp+lL.lLSYFIRCSElpc	...................................................................................sh.st-osusssuhlR+KKIAIulIFSL....................scp--tpp.........pFp-FFFSHFP....LFESHMN+LKSAIEpAMh.......................p+hutsu.php..hhh.sRlh-ALsEF.RsTIpNLYoh.........PRIsEPVWLTMMSu.........................................o.EKspLCpRFhKE.FshLhEphsKNQ...FlsALlTAVLT.HLAWVPTVMPsspP........PI+hF.EK+oSQSVshLAKTHPY.NPLW.AQL.G..DLY.G..AIG..............SPVRLuRTVV.VG+cp-..hVQRlLYhLTYFIRCSELQc........................	0	30	38	64
+14489	PF14638	FNIP_C		Folliculin-interacting protein C-terminus	Eberhardt R	re3	Jackhmmer:Q9P278	Family	This is the C-terminus of folliculin-interacting proteins [1,2]. This region is responsible for binding to folliculin [1].	25.00	25.00	29.90	28.70	20.10	21.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.25	0.71	-4.95	16	160	2012-02-22 08:16:55	2012-02-22 08:16:55	1	7	88	0	99	144	0	183.60	49	17.82	NEW	clPhPpsp.hp.s.s...............shuRSLhuGhs-sYsPDFVLpG..hsssc.hcpp.....................LtsD........LthusppSsl--s..luEuVsIlADsDsWsVplhSSpppshs.......uh.VusSplVs...........uMLpShhsLachshssp...FClhaLED+LpElahKScsLuEhL..............pssst.lshcclspsLGl-tuDlPLLluVAusHoP.Vs	........................................................lPhPt..Sp.lpsptst.s.t............NFG.RSLLuGYCsoYsPDhVLpG.husD-+.h+Qs...........................LhuD.....LsHuVpHPVLDEP..IAEAVCIIADhDKWoVQVASSQR+ss-..K.............LGp-V...L...VSSlVS...........sLLcShLQLYK.h.sLsss...FClMHLEDRLQElYhKSKMLoEYL............................................+GphR.VHVKELusVLGIESsDLPLLsAlASTHSPaVA........................	0	26	34	62
+14490	PF14639	YqgF		Holliday-junction resolvase-like of SPT6 	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	The YqgF domain of SPT6 proteins is homologous to the E.coli RuvC [1] but its putative catalytic site lacks the carboxylate side chains critical for coordinating magnesium ions that mediate phosphodiester bond-cleavage [2]	35.00	35.00	35.00	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.64	0.71	-4.65	4	495	2012-02-22 14:01:54	2012-02-22 14:01:54	1	42	441	2	270	514	14	143.20	28	12.53	NEW	pGKh.+VLuluhupGR..scslhCshVNscGEssD.L+L........shc.c-+ppptp.hEsLcpFl.spKPcVluVuG.NhcAphlhcclpcslpch-..spph.slsl.hV-sElAlLY.NSc+utsEF.shPPll+.sVuLARhlQsPLlEaApls	..............................................h.....................sh.h.h.shlctsGcll-phpl.....................................h.s...t.psp.p.p...c............p...pshpp...L....t....ph....l.p...p....+.csclIul..s...G.t.u.t...cop.c..l....hcclt....c.......h...l......p.........c...........h..............p....................t..............t.....................p...................lt.......l..hlVs-psAplYpsSchAtpEFP..c.h.s.s.hlRtAVSlARpLQDPLsEhs...t.........................................	0	95	154	231
+14491	PF14640	TMEM223		Transmembrane protein 223	Coggill P	pcc	Jackhmmer:A0PJW6	Family	\N	22.00	22.00	22.30	22.20	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.93	0.71	-4.32	14	99	2012-02-22 14:08:19	2012-02-22 14:08:19	1	4	75	0	62	100	0	152.60	31	73.24	NEW	+DVlLFca-ps+FF+hLslFuhsQhhFWsYLuaFu..ho.....cs.ss.p.c.ppchshhptl...............s.LupspaR.Glshhs....lhlGshlLhsuhhFoLRSVptllLp+GGppVolhTYuPFG..ppRthsVPLcplSshtsRpps..pu.lPlKVKG+tFaalLD.pcGcFpNspLFDhTVGlpRp	.......................................................................pDlhLaca..cps.+FathlshFshsQhhFWs.huhhu.hs.........ps.s..........tc...ht.h.................s.htsshaR.Glshhs....hhhGhhlL.hssh..h..FshRSVp.lhLppGGp.....p........VslsT..auPFG...h.tpph.s..........V.......PLppVSsh.spRtps...s.lPlKlK...G+p....haalLD..+tGcF.NspLFD.TsGhhR............................	0	23	30	44
+14492	PF14641	HTH_44	HtH;	Helix-turn-helix DNA-binding domain of SPT6	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	This helix-turn-helix represents the first of two DNA-binding domains on the SPT6 proteins.	35.00	35.00	35.20	35.30	34.40	34.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.59	0.71	-4.12	4	227	2012-02-22 16:49:36	2012-02-22 16:49:36	1	29	207	2	176	238	0	131.10	33	8.87	NEW	LpshsshsuEDDELEEpstWIhcphhss.shshptsh........hosFp.......ptI+pAlpFhpppphEVPFIhhYR+-Yl..........pP.Ls.NDLWclaphDpKappL+s+KpslpRLapchph..........DcPLs	.............................................h.hp.-..-..ELc-EApWIhphhhsc.p.s...hs.h..ppsh....................ppsFp.....................ptItcsLcFhp..spphEVPFIhhaRK-Yl...........................................................................c..............Ls.hsDLW+laphD.KappLhp++psLp+ha-p.hpt...............h........................	0	58	92	143
+14493	PF14642	FAM47		FAM47 family	Coggill P	pcc	Jackhmmer:Q5HY64	Family	The function of this Chordate family of proteins is not known.	27.00	27.00	27.70	27.40	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.90	0.70	-5.09	2	239	2012-02-22 17:41:02	2012-02-22 17:41:02	1	10	33	0	65	246	0	127.20	33	63.46	NEW	MGDpRPQDRPpS.GMDSpPWYCDKPPSKYFAKRKHRRLRFPPVDTQNWVFVTEGMDDFRYuCQSPEDTLVCRRDEFLLPKISLRGPQAD.KSRKKKLLKKAALFScLSPsQPARKAFVEEVEAQLMTKHPLAMYPNLGcDMPPDLLLQVLK.LDPERKLEDAhu.CEupEKTT-.PTEsGKYPCGE.sPRPPET.VSpL.Pp.PKTPVSShRPEPPcTtVSpLRPpPPKTpVSSLH.EPPETtsSHLRs-PPcTtVSp	........................................................................................................................................................................................................................................................................................................................t....hsp..........t...sps...hS.p..Lp.E.P..Pc...T.t.s.SpLp..EPsco......s.Splp.-P..c...t.h..s...........................................................................................	0	28	30	38
+14494	PF14643	DUF4455		Domain of unknown function (DUF4455)	Eberhardt R	re3	Jackhmmer:Q9P1Z9	Family	This domain family is found in bacteria and eukaryotes, and is approximately 480 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	28.40	28.40	29.00	28.80	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	474	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.31	0.70	-5.86	16	121	2012-02-23 13:51:07	2012-02-23 13:51:07	1	10	67	0	82	82	0	353.80	27	33.39	NEW	ht-s++c+appslsuhpc-hsplup-hEstltcsutthhpplucsDpplsplhspl-s-ssLhchohppLhpla-pVsp.ch.h+pphIcpL-psLpphEppRt-pLcssLc+hhptLpchualhps-VpRhlscEAMtlNpslLtNRRAhAcLhhpLhpsclcpEtspctcWppthccW+sL+ppphlppFp-hhtStchtsPsphpphhEshtcpQtslpppRhchlpslsslhP................Pshopsp....lpcWhsslpslscph....sphptpthtcl+tph-csppcshsplpph+ppLhphts..hsp-ctpsLVstchh.hssphpppscchLEthcphhEphutphcppspsLhpahpclspha-tHppthtpp-t-lppclcptRppasppppppEspLDthlcplpptusEpsLctplcpshshLcplcppYcsF+pphsplsppYPstlhpphpsYppsLsphhtlcchhcpshtsph	.................................................................pppta.thh.th.ppht.ls.php..hhp.tt.h.t.l.p.stthp.hh.thttp..h.thphpt...l.plhppltt.....ppp.IcphcttLtphE.pRhppl...pthLpchsthlpchuahh.s-l.+llppcuh.hNtslLuNc+uhupLhhpLhpsplpp-h.ptphc.WpthhpsW+tlp+pthlppFpphhts.tphppP.th...............p........hpthhppQ..lt.p.pRhph.Lpplp.shhP......................................Pshspsp....lpcWhpplpslppph....sthphphh.pl+h.h-phhppsht.hpph+......ppLhphth....h.spcchpphlp..h..h........hhtthttphct.lchhtp.h-t..ttp.p....tplhpahtthsthh-.pt...h...p.ph.pphtphptt.p...t..ctthp..htphp.tsp.tttLt..ht.s.t.Lt.hp..h.............t.................................h.................................................................................................	0	37	50	60
+14495	PF14644	DUF4456		Domain of unknown function (DUF4456)	Eberhardt R	re3	Jackhmmer:Q9P1Z9	Family	This domain family is found in bacteria and eukaryotes, and is approximately 210 amino acids in length. There is a single completely conserved residue E that may be functionally important.	25.00	25.00	25.10	26.80	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-10.93	0.70	-5.10	19	84	2012-02-23 13:52:56	2012-02-23 13:52:56	1	8	59	0	55	72	0	181.90	26	14.14	NEW	hhshs-.aYcpct.p+tlsRPppl.psh-phs-slppplpph.pppupcappsslpchRsQlpphpphhpplsthlhpshhppahpphppuhpslppc.Fpph.pphppp+pp+tppLRPsLucPsphpELcsLpppEpcRppch.phlpphpptlh-sttp.uptFlppLsphspphlhhhD.phlhh-Dltssshssspp+pthhhpp+h	.....................hths-taacpc..pc.hptPpth.psh-pss-tltptl.ph.pppsppYtspslhchRtQhpphpchl............spl...........s.llhpshhppphpphppshpplptp.Fpp..pphppt+ppptppL+ssLu+PtphpphcsLpppEppRppch.phlpt.pptl.cphpp.uphFlspLsshscphhh.LD.plloh-Dltssphts.ppphphhhppc.......................................	0	30	38	46
+14496	PF14645	Chibby		Chibby family	Eberhardt R	re3	Jackhmmer:A6NI87	Family	This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila [1].	23.00	23.00	23.70	23.30	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.34	0.71	-4.20	14	172	2012-02-24 08:43:10	2012-02-24 08:43:10	1	5	85	0	109	173	0	115.10	33	58.82	NEW	MPLFup+...FSPK+sPhR+suShSsh.pslDppTcphEhuhsaGssphcLu.spplhF..csGpWh.........s.us.sssssspcst+L+KcsppLpEENNhLKLKh-lLLDMLoETTA-sHLhEKEl-	..................................................shht.p....Fus+phP.R+.tS.ssh..psh-+soc.p.s-LtL-.Y.ssPphpLu.spphhF..psGpWl..............................tp.u...ptssstc...-spp.L+ccsptLcEENNhL+lch-lLlDMLsppss.c.p...................................................................................	0	25	35	60
+14497	PF14646	MYCBPAP		MYCBP-associated protein family	Eberhardt R	re3	Jackhmmer:Q8TBZ2	Family	This family of eukaryotic proteins includes the mammalian MYCBP-associated proteins. These proteins may be synaptic processes [1] and may have a role in spermatogenesis [2].	24.50	24.50	24.70	24.70	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.34	0.70	-5.76	34	181	2012-02-24 13:32:21	2012-02-24 13:32:21	1	5	93	0	112	180	2	330.40	21	48.95	NEW	ss.phDpRL+pWpchLppR++hQp+lp+chGKpss-lLhNpssTl.....Rsppph.....+cllD...hsp.Psp..ppcs.....hp.hu....thhpp..p.phspp......lstLt.ThP+sEctt..slE.hlGLPpss.ppElhu........p......tptphpspWp+..SphLppRlcctppslccllp..ah..PDl-..sLpV....lGps..h.......hpss..................pspphph.pps.........................ppt...spp-ph..pp...sth....pp..ps.c.....s..p...sh....ps......ulph....supsh......hhh.s....tssp.p.....................tphshthplhFcC.......cPhp.+s.h+tlh.lcNlGspslphpWpphshhtpht...........s..hhhspspcFhF-ppshhlhPGEs+phplhFpPppsulhpppWc..Lp.h.pPslhu................ppt.lhl..pL....pGhChssspatp+hpchpptlhsKpppphsppL..h..pch.....LssllpPspsh......CPY.-RhlsEcElFsstN....PG.a+....s.R.a-DLEsL+pLapplK	............................................................................................................................................................................................................c.hLp.Wpp.ht.ppt.pttlt.phht+.sp..phlhp.spph.....Rphtp.hphh-...h....h...........t..s.....hhp...................h.th...sh.sphp.......l.p.hhths..h..p..Eh.h.........................a.p..S.hL..+hpp..t.htpl..........s..hs..tLpV....hGps.................................t.tt....t...........................t......t..tt............t...................t................................t....sh.h....ts..h..................tt.t......................t.s..h.plhFps.........hp.ph.pplh.l.N.GshslhapWpph......t.....................................................p...hh.s.p.ppFhF.sp.p.thhlhPGchpphthhFps.psG.lhpphWphts..pP.lhs................tt...h.lpL....huhs.h......h..tthp.hpp........h.tptt..hhppl..h..pph.....l.sl..s...s.......s.Ph.pt.hpcp-hFt..N.....t.h......h.p.t.h..l.tha..............................................................	0	45	53	80
+14498	PF14647	FAM91_N		FAM91 N-terminus	Eberhardt R	re3	Jackhmmer:Q658Y4	Family	\N	25.00	25.00	27.10	26.00	22.40	23.40	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.75	0.70	-5.37	14	179	2012-02-24 15:46:41	2012-02-24 15:46:41	1	12	117	0	114	165	0	259.20	44	36.29	NEW	ptIRpNhsWppLPssl+ptLGsSp+-Y-KtVlcYS.l+sQLRa+sNlV++lt+cEcpYY-cLlcYSpppLhLYPYHLuDlll+tLRlTPFsYYhsllsclLpsE+SYDuLPNFTAADCLRLLGIGRNQYI-LhspsRSs.......+phFt.++ss+chLPppPl.hth.-PWWhVpsGhlhEsDl+h....Lo.tE+shlDpLIDpGsp.....................h.AGpLchslVpuLYpKGLlYL-VPlss-DhIsVPPL-G.FVMNRV.GDYFEsLLYKIFVolDEpToluELAplLplDlppVKsAlSlaCRLGFA+KKs.sslsp.......spl..HsSWts	...........................h.tlcpphsWppLPtplpp.Ltsopc-Yc+pll.Yu.l+ppL.cacssh....sp+lhpcEpcYYEcLlcYspppL........hLYPYHLu.....Dh.....hs+shRlTPFpYYhslht.....-lhpsE+SYDoLPNFTAADsL.RllGIGRNpYI-lhNpsRSp.......+.h.h....h....h.........+p.hs+-hLPhpP.lchsl.EsWWhlphs.lsp--l+h....ho.tEtshl........Dcllcpss..p....................................................................................................ss.h-hpllpuLYp+GhlYhDVPlps-s.......plt.VPsL.EG.FVMNRs......p..s......D.hEsLLY+lFVohDEp.ssVuE..............LAphL.......plDLp..lpsAlShhCRLGaApKc.............................................................	0	41	62	89
+14499	PF14648	FAM91_C		FAM91 C-terminus	Eberhardt R	re3	Jackhmmer:Q658Y4	Family	\N	25.00	25.00	33.10	26.90	23.90	23.50	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.63	0.70	-5.65	9	246	2012-02-24 15:50:15	2012-02-24 15:50:15	1	12	117	0	173	235	0	274.80	26	51.76	NEW	s.sKRIAFLFDSTLTAFLMMGNLS..PsLKsHAVTMFEVGKLSDESLDSFLtEL-+V-p.suEGEAQRYF-HAlTLpsTlLFLRpscclh.p.s.Pc..shshulDLLRsESL.uLDssTpSRVLsKNYpLLVSMAPLStElRslSs.ssPsHhGPsIPEVsSsWFKLaLYphhGpGPPSLLLsKGoRL+plPslFpca-+LLlTsW.......................GHDsulVssSNsLlhLNDALoHSAVhlQuaG.hhsp....u-..............olplPFPFpcs-hth...Fohsphph.H.ulppLcpplsLpa.pCGYlThLs......tspph.tst.......st.ttsthpsshs....ht.t.poFshstc...pth........ss.uppp.pptsssps-Wh.L-lsFGlPLFcu-LNpclCc+IsuppLhpc-slpplhpusRcLuhplhpFlppaQshspssc.pst...su....lspss..........ttuslPhPspsLlFcsGcLs.W-	....................................................................t............................................................................................................................................................................hlp.tth......t..ph..htY..hh..........................h.......................h.h..........t.s...............shhh.hG......h..hP..h.............t..ph.....h.......................t.p...hh..t..h..hNp.h..tslhlp.h.......................................................................................................h.s........................................................................................................................................................................................................................................................................................h...th.hGhs...l.t..hs..hh..h...th......................................................................................................................................................................................	0	57	98	136
+14500	PF14649	Spatacsin_C		Spatacsin C-terminus	Eberhardt R	re3	Jackhmmer:Q96JI7	Family	This family includes the C-terminus of spatacsin.	25.00	25.00	25.70	27.80	24.80	21.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.89	0.70	-5.54	28	154	2012-02-27 09:55:58	2012-02-27 09:55:58	1	4	102	0	95	154	0	263.60	33	14.19	NEW	ohlGppLl..................ch.spu......................................................s.........pct.p...........hsshVELLIp..AHpCFstsCsh-GIspVLpts+phs.shLspspcasLlVRLloGlucYpEhpYlFDlLlcscQFEhLLp+.p..h..........Dp.......t........sG.......L+hAlLsaL++hpPp-p.-taphlsL+FsMa+ElAphhcpcAc.ptl.chlts..............p.s...............p............ppsphpppL.p.uhcpahcAA-sYhp-sshphAppCsppApLluLQlclh...............................ph...pllsLs................csphcchlspphsF.pALIlAcAYsh..pssWupsLapQhlhtGsh.pYLp-Fhphhslssslhp-ls+pYptc	.........................................................lG.tLhch.h.s..........................................................s.......ph.............hps.sELLIh..AHpCFshsCph...-GIh..plLptsphhs.sths...spcauLllRLLoGlucap-hpalF-lLhcpc..FEhLhp+.t............-...........ts....l+hAlLsal++h.pPtDp.-tashl...........sLpFsMh+Elu.p.hEstAp.tl.chl.s........................p.s............................ps.phpp.LhpuhphhhcAAEsasp-sshppAp+stphspLlsLQl+hh.........................................................sh.hllsLs................cpphhchlhthspF.pA.IVAcAYs.h....s.s-Wu...plLapphlh.ssh.pYLpEahp.h.Lpsshhp-ls+hap.............................................................................................	0	35	50	71
+14501	PF14650	FAM75		FAM75 family	Eberhardt R	re3	Jackhmmer:Q63HN1	Family	\N	24.00	24.00	24.80	24.40	22.40	23.60	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.21	0.70	-5.07	23	316	2012-02-27 11:20:10	2012-02-27 11:20:10	1	7	25	0	203	266	0	228.50	24	29.28	NEW	Qphsas+shpD.pLppKssQLFWGLPSLHSESLsusshlssssSshp...hlFNchSss.Ph..psphos....................hLopspPLshsphQsQs..hh.shPQ.Qs...PlsphpsQApLpsslPlls....PSs.sQl+sCGVsa.ssQscspsLhPoEIppLEaslLpKQ.EpthsLPolVc+SQcsFs.ssPshspcs.....ts.psphssSIhPssFslosEL+++LEpHLpK+lIQcp..WGLPpRIpcSlplhpPQsEhstsspucuppG.....sSp.ShhpucuspsspK.st...stp........hphcpchs+.shspsltph.KDhsts...psossscl.tsssEpphps...........t..pscstts..hu.s+ccLEssLcsHLs+KhspIsEG.lPsoV+pSh	.............................................................tp...phFhGlPshpSESl.s.h.........h......t..................................................................................................................................................................h..t.p....t................t...p...th....+t.p.....hsshhpp.....t................p...................................hshhst...p.h...h...c.h.pp..h-.+lpc.hh....p.p...s.st+lp.S.ph.h.........t....t..................................................................................................................................................................................................................................................................................................	0	20	20	30
+14502	PF14651	Lipocalin_7		Lipocalin / cytosolic fatty-acid binding protein family	Coggill P	pcc	Jackhmmer:P51161	Domain	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.78	0.71	-4.42	3	209	2012-10-03 08:47:39	2012-02-27 14:48:16	1	2	77	40	108	690	0	119.60	38	94.68	NEW	MAFTGKYEhESEKNYDEFMKRLGLPSDVIEKARNFKIITEVQQDGQNFTWSQpYSGGHoMTNKFTIGKEC-IQTMGGKKFKATVQMEGGKVVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA	................MsFsG.p.aph.p..op.ENa-tFhKs..l..G...lP..p...-.h..I..p..+...u..+..shK..slo.Elp.Q.sGpcFsh.ot.....h.s..s.u.+..s..h.s.N.p.FT..lGc...Es..E..hp.T..hs..Gc....KhKss.....V.ph.EG......s....K.......L.....V.....s........s...h.............s......h.......p.......p........s......p......E....l.....s.....G....s.p..lsp...s...Th....u...sh....sh.RhSK+..........................................................	0	29	39	68
+14503	PF14652	DUF4457		Domain of unknown function (DUF4457)	Eberhardt R	re3	Jackhmmer:O60303	Family	This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.	24.00	24.00	25.60	24.30	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.96	0.70	-5.47	14	419	2012-02-28 08:56:53	2012-02-28 08:56:53	1	6	92	0	292	386	5	183.50	19	50.48	NEW	plplhpoWGDtaYlGLTGlEl.....l.spptp.lslshpplpApP+DlN-lssapsD.RTLDKLlDGhNlTT-DpH..MWLlP....as..tpcphlsIchsptpsluulRlWNYNK..Sh-.....DoaRGsKhlpl.lDsph.lss...........ssallRKAPGs.spFDFuQsI.h.phppp...........pshp.hsphpt.h...............h.........pp-YpsshhPsGalh+h.LloTWGD.aYlGLNGlElaDtpGppI...plp.psls..AhP.SVslL...shpsDsRTs-+LlsGlNs.TasspHMWLu.........Phhsu......................psNplYlhF-pPlslShIKlWNYSKTPpRGV+EhtlalDDlLlYpGhLcpssp	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s................h..h.h.hpsaGs.....hultthphhs.......................................................................................................................................................................................................................................t.......................................................................	0	118	148	223
+14504	PF14653	IGFL		Insulin growth factor-like family	Eberhardt R	re3	Jackhmmer:Q6UXB1	Family	This family includes the insulin growth factor-like proteins. These proteins are potential ligands for the IGFLR1 cell membrane receptor [1].	25.00	25.00	26.50	31.60	24.00	24.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.01	0.72	-10.83	0.72	-3.97	9	151	2012-02-28 09:38:21	2012-02-28 09:38:21	1	5	23	0	106	129	0	68.80	44	82.70	NEW	hs.u.ssschhhCp.hPRCGc+hYNPhcpCCscssllsLs+T+h............CG.sCTaa...PChchCC.tphs.spp+aVVKLKshGhpu.p..sPloppC	.................u.hhPchh...hC..hPRC.Gc+FYNPhcapCscsphl..s+T+p............h..................................................h.......................	0	74	74	74
+14505	PF14654	Epiglycanin_C	Mucin_C;	Mucin, catalytic, TM and cytoplasmic tail region	Coggill P	pcc	Pfam-B_ 91014 (release 26.0)	Domain	This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins [1].	22.40	22.40	22.50	36.30	21.30	21.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.52	0.72	-4.03	5	31	2012-02-28 11:02:14	2012-02-28 11:02:14	1	10	13	0	14	32	0	100.60	66	14.78	NEW	SAoTPVsEsKPSGSLKPWEIFLITLVSVVVAVGLFAGLFFCV.RN.SLSLRNsFsTAVYaPHG.N..LGs..........................GPGGNHGssHusuWSPNWFWRRPsSSlAMEMpGthsRP	.........pAoTsVSEsKPuGSLhPWEIFLITLVSVVsAVGLFAGLFFCV.RN.SLSLRNsFsTAVY+PHGhN..LGs..........................GPGGNHGsPHRPpWSPNWFWRRPVSSIAMEMoG+tsG.P.	0	6	6	6
+14506	PF14655	RAB3GAP2_N		Rab3 GTPase-activating protein regulatory subunit N-terminus	Eberhardt R	re3	Jackhmmer:Q9H2M9	Family	This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily [1].	25.00	25.00	25.20	25.10	24.60	24.00	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.42	0.70	-5.47	21	180	2012-02-28 14:10:59	2012-02-28 14:10:59	1	8	138	0	125	175	0	330.20	31	32.33	NEW	WL.ssssl..ulussu-hlslAtsp+hslLsstW...pps.stsshthshpusl-sts....ppITulphlPhsstt..........-hsslulGhoSGalhFYoppGsLLhpQhhp.pcsllpl+l+ssppht..t.........cELsllYP.sslshIsGhsLhshLpsshppls+sthstpt........sts.ssLsapKWsh..scts...slsDsulsGshhsshF-.h.............h.ppos.phsphlssGscPhluaahspE.Gtspslluslhp.uVuuploohl.........huhh...uts.pppppssppp................ps.sshssRhsLhDttRcGpslsluPs.spLAAlTDsLGRVlLlDstpslllRlWKGYRDApCuFlpshpcpsp............sppscpchu..............................LFLlIaAPRRGlLEl.Wshps.GsRVsshss.uKss+Ll	.........................................................................................l..t..h...hs.t.phhshu.ttp.hhh...h...............h.h.h.t.hp.............p.louh.hlsh.t.t.................-.hhslslGhssGhlhhaot.tG..hlhtphh.............p..p.lhtl+hps..h....................ppl.llas.sslshlpG.slht.Lptthppltpst...htt..............s.lsapKath..pp.s....h.Dts....h....G...h...s.a-.h...........s.h.pto....s.thsphlssGtsPhhuhahs.E..s..tsp...sh.lucls.h.uluuph..sshl...............................tuhh..u.ht.tppppps.sppt.t.....................pss.sshs.s+h..sL..DscRcups..lsluP......s.s......p.LAAl.T.DshGRVhLlDstpslslRh...WK...GYRDAphuWlphhpphtc..............................t.t..pchu................................................................................................................................................................................................aLlIYAPRRGllEl.Wshpp.GsRlsuhsl..u+tspLl..............................................	0	51	69	103
+14507	PF14656	RAB3GAP2_C		Rab3 GTPase-activating protein regulatory subunit C-terminus	Eberhardt R	re3	Jackhmmer:Q9H2M9	Family	This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily [1].	25.00	25.00	27.30	26.60	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	595	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-13.12	0.70	-6.38	9	135	2012-02-28 14:11:58	2012-02-28 14:11:58	1	6	90	0	89	126	0	456.10	34	43.64	NEW	cDLLoLllsaWLpKshchhpps...-shscltphlphLschtush-p..sashpslSPWWQplRchllpScph.uuLLsAlVs+sVAsphh....cstp-tp..hspsshtss....pEpWEplShDtptWsLLhtpLEDlhlLtslLsps....hssppshssph..-.hsc...sSLKslLpuG+.GhVsEhlAKWlhpstLcP.cll.tlssscppp-s.........................s.....p.....htp...t.pt.....cls.h-.............sl.-hLplLpp+FPhSL-ssVLluphuWEYhVpWsKs.pp...hcaLptulcpLctltss..tlpHGICtMlWNshLhh.hpAs.shLhpKVG+hPKD+hCppDlsMSs..stlspFLchsl-hLpph.suslscDchph........caE-uh..sEG......shPlp.LALpQ+psphsLlphHppLsoVLahlspFpl+ssKPLo.LFDuh.GppAFFtDlsp..hhs.sssD.slhp.RppFLp+VVoushch......hcps.pplh....ccltahsphscLAppWplsps.l+++.VsELYuaGhDt.Ac-lLhsls-cEhLup.LL.lAGpRLs..Lhsp..poppsh.h...lAslsspLhsaLcshp................sphcs.........splslssls+Llp+lhcpLsc	..................................................................................................h..hhplhl.hWhph....t.h..........htphtthl.hlspht..s...p......ht.pt.....l....S.WWpph.Rt.hhhpSpp.htu...Ll...sAhls...+tsuhph...............................pph.tc.tp............................p.......ppWEtlS...h-.....p.WtllltpLEDhhlLpslLtp........................hs.......p..hsp...hSl+pllpuG+.G....hls-.luKWlhppshsP.phL..p.h..ppp.-..p.........................................................p..................t.t..t......................phlt.hhhppFPhS..Lp.slLhuphsWEahspWsKc.pp.................hphh.tulphL.pt..l.ss...tlppGl...........sh........hhWssalhthhpus.shLhpKV..G+.PKD.....+hCppDlGhu-..tthspFLt.ChphLphh...hpusht..-chph............hphEchh.....s-..G.......................s.slspLA...l...pQp.....h.hsLlphH..LsslLahhhpF..pl+..sKPLs.LFDuh..uppAhFp-..l..ssh...hh..s..sphD.sh.p.Rp.pFLh+llsu...shph....................tth..................tt..a...thshpLAp.hp.lst-.l+c+.VsELYphGhDt.ucphlhplp-p-hLuspL.L.hl.sGpRLs...Lhpp..psppshth...luplsspLhsaLcshp..................htp.............thsl..htpLltphh.hLs...................................	0	31	37	66
+14508	PF14657	Integrase_AP2		AP2-like DNA-binding integrase domain	Bateman A	agb	Jackhmmer:C9L423	Domain	This family includes AP2-like domains found in a variety of phage integrase proteins.  Presumably these domains are DNA-binding.	22.10	22.10	22.10	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.27	0.72	-4.18	212	1784	2012-10-03 08:51:45	2012-02-28 14:47:41	1	10	978	0	198	1338	40	45.30	27	12.51	NEW	pWhhph...thpshsGK++pppK.pGF+TK+EApphtpc....hhtp.....hp.....psht	.............ahhph...thcs.sGKc+ppp+.p....GFc.TK+EAptthtc....h.tp....hp.p...t.............	0	77	133	168
+14509	PF14658	EF-hand_9	efhand_7;	EF-hand domain	Coggill P	pcc	Jackhmmer:Q8N6L0	Domain	\N	37.00	37.00	37.00	37.00	36.90	36.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.14	0.72	-4.06	8	82	2012-10-02 16:17:27	2012-02-28 15:26:37	1	13	55	0	37	112	0	65.20	37	17.67	NEW	-shFcsCDsp+sGcVslS+llsYL+tsTup..sPp-s..cLpsLsp.LDPsGc..csslsLDTFpsVMRcWI	.................sFphhDsp+TGhlsltclhshLcusst...sPp-u..cLQsLhsplDPpup...uplshDsFhslMpphh..........	0	9	10	18
+14510	PF14659	Phage_int_SAM_3		Phage integrase, N-terminal SAM-like domain	Bateman A	agb	Jackhmmer:C9L423	Domain	This domain is found in a variety of phage integrase proteins.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.77	0.72	-3.70	221	5045	2012-10-02 14:21:04	2012-02-28 17:25:28	1	28	2378	11	835	4073	332	57.40	19	15.31	NEW	oFpchh.cha..hcp.hc..tpl+.tsThtspcphlcp+IlPhF..GphclscIs..stplpc.ahNchh	..........................Thpchh.cpW.....hc..p..hp.....p.......p.......l.....c...........s........T.hpphpp.hlc..pal.h..P..h..h....G.ph..p..l.scIs..stplpp.hhpph.h...................	0	320	580	723
+14511	PF14660	DUF4458		Domain of unknown function (DUF4458)	Godzik A	adam	Jackhammer:Q8ABA0 	Domain	this domain is found in tandem repeats on the N-terminus of secreted LRR proteins from human associated Bacteroidetes domain boundaries are based on the JCSG solved 3D structure of JCSG target SP16667A (BT_0210)	22.40	22.40	24.10	29.30	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.50	0.72	-4.06	25	61	2012-02-29 08:06:47	2012-02-29 08:06:47	1	11	24	3	2	57	0	115.00	32	26.05	NEW	GhVpFKLhKsh.......pt..pts.soRA............s..sc..h.h..hu-hpKlc.lslpp..stTphspTl.....t.Lpsh.s................ps...u-.....................hGhco.....-pL.pLhAGsYplsuYphY......c+pc...pp...lhs.upss.pspsFsVhsssls	...............GhVpFKLhKsh........t......soRA............h..sch.h..hS-hpplc.lslpp..shTphspTl....t.lcshhs................Es..s-.....................auhpo.....-pl.pLhAGoYplhuYhhY.....Dchs.....ps...lht..upss.pspsFsVhsssl...	0	2	2	2
+14512	PF14661	HAUS6_N		HAUS augmin-like complex subunit 6 N-terminus	Eberhardt R	re3	Jackhmmer:Q7Z4H7	Family	This family includes the N-terminus of HAUS augmin-like complex subunit 6. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].	26.30	26.30	26.60	30.90	23.90	26.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.66	0.70	-5.02	27	214	2012-02-29 10:59:24	2012-02-29 10:59:24	1	4	158	0	141	215	1	211.80	21	32.99	NEW	hlapsLphLuhch.sst........shpthhshshF.KsNhpAh.hlhaaLFphhDssch+.c+Ft.hWP.hDp..tpcssFRssshchLpc..Lpcpt.tLsphspl+sshlspssG.+FhchLhphusaVlpchl+p.....h..pssssshths.spphtsss..t.hhshhtthcsphhphhpcpsth.t.apchsphlppphcslsucptt.ppth.......thpsppcpttcth.p...tt.......h.t.hpphpphWsph	.......................hhh.l.hLthc...............s.p...t.s...ht+...phpshphshaaLhph....h..D.st....tp..p...........thp.....haP.h-t..hpshphRtthhphLpc..lpcps..sLs.........p.sp..l+tohlhpssG.+FhclLhphuphVLpchlpp........h...........p...........s.ssh............p........hs.ttphtspp..t.hhshhhht..+.pphhp.hhpcpsth....t.apchs...phlpt....phcplttcp.thhppp..................p..pp.tp.......................................................................................................................................................	0	34	66	108
+14513	PF14662	CCDC155		Coiled-coil region of CCDC155	Coggill P	pcc	Jackhmmer:Q8N6L0	Domain	This is a small family of eukaryotic proteins of unknown function.ThiS is the central coiled-coil region.	30.90	30.90	31.50	32.00	30.40	29.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.38	0.71	-4.70	15	48	2012-02-29 12:47:12	2012-02-29 12:47:12	1	8	33	0	25	66	0	163.10	59	29.74	NEW	PATADLLSSLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEIpALRKQLRSTQQALQhAKAlDEELEDLKTLAKSLEEQNRSLLAQARQTEKEQQHLVAEMETLQEENGKLLAERDGVKRRSEELATEKDuLKRQLaECE+LICQRDAlLSERTRHAESLAcTLEEYRoTTQELRLEIS+LEEQLSQTpE	.....ATADLLSoLEDLELSN+RLsGENAKLQRSlETAEEuSARLGEEIhuLR+QL+..ST....Q....QALQhAKAlDEELEDLKTLA+SLEEQNRuLhAQARpsEKEQQHLVAEhETLQEENGKLLAERDGVK+RSpELAs..EK-sLK+QLhEsEcLICQR-slLSERT++sEuLspTlEEYRssTQELRhEIS+LEEQLSQo.p.........	0	2	4	9
+14514	PF14663	RasGEF_N_2		Rapamycin-insensitive companion of mTOR RasGEF_N domain	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.	27.00	27.00	27.90	27.40	26.40	26.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.35	0.71	-4.14	35	251	2012-10-02 12:00:54	2012-02-29 13:10:47	1	25	215	0	179	269	0	112.50	36	8.19	NEW	phssa.ppWulcLLl...sQLhDsss....pVsthA.lplLcEsCppp..ssLEhllph.+.PsLspLG-hGt.Llh.+FLSpspG.a.phLsp.hsalppEh-pWh.pptNpcYVtllEsslppuhssptcs	..............s....hppWuIcLLV....sQLaD.sh....pVsptA.lclL-EACpp+..s.Lchl..lp......h........+.P........s.L.........s....H.................L..G..-..h.....G.t...........LLl.....RF.LShstG.a.p..Y.........Lsp.h....salspEh-cWh..pthNppYVsllEtpLscuhsp..........................	0	57	94	147
+14515	PF14664	RICTOR_N		Rapamycin-insensitive companion of mTOR, N-term	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.	27.00	27.00	35.40	31.00	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.00	0.70	-5.87	30	301	2012-02-29 14:25:56	2012-02-29 14:25:56	1	28	234	0	209	292	2	316.30	29	26.27	NEW	lp+uNsLVpLh+cpPpl+h-lshuhhs.clps...hLLscs.+-VsAAuYRhsRYhlsDtpslptlppLphDhlllhSLs+-p+s.plEREQALKhlRsh..l-l.tulpch..opulVRsllulA-c....p-DRL+shsLpTLsElhlhsPpLlhpsGGlpsLtcsLh-.usap..huEolhsslLaLLDsPpTRpalpssh-LcslhusFTD..............pscpt...t+lpsSshuIushL+oWsGlhhLupssh.psL+SLlssLplPpsp.lRcsll-Lla-lLRI+sPsWossFhsup+hsshup..h...hplp.....spspp.h...s.....t.tt.slhspahALlLhshlcuGL...lpuLlpllpssp..........ttLspKusl......LLuElL+LAsplLP	..................................................tphNphspLhpp.hs..+.c...hsh..h.c..l.h........hlLscs..ppVhAAuhRhhRYhlts....p...lphlhplp..h-hhlhhslsh......p...........p.....p...............s..phERp.............QAL+hlRt..h..lsl.............s........sp..............h...............spulspsllulupp............................pcD...c..hhphslthlsElhltsPpllhhsGGh.pslhcs.lh-...sphs.....hs-s..lhsshLalLspPpoRpalcss..h-.L-h..lhusao-h...........................hpppp.........+hpssthslhshh+oWsGll...........hst..ss...ps...lp.....u.....L.ls..............sL...ph......P.p...p......hRchll.-lla-lhp........l.......s.....s.....htpphh.u.h.h.ss.sp...h....php.........tt..t.h....t.............................tp.slhppahuLlL.hhlcsGL...............lpsLhplhpsp.s..........................lph+uol......Lls-lLphupphLP.............................................	0	76	116	174
+14516	PF14665	RICTOR_phospho		Rapamycin-insensitive companion of mTOR, phosphorylation-site	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site.  Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.	27.00	27.00	38.40	37.20	25.90	18.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.63	0.71	-3.98	4	57	2012-02-29 14:26:48	2012-02-29 14:26:48	1	8	36	0	29	52	0	105.60	69	6.89	NEW	PFshhuSS+LV+NRhLNSLoLPsKKtRSoSDPKG....uKL.os-ohsuhRRsRTlTEPSl.s.spu-sFsPl.p....P+p.TlsLETSFsGhKsl--ssSTsSIGEN-lKhs+s.u	....................sFPFFASSKLVKNRILNSLTLPNKKH..RSSSDPKG....GKL.SSEsKoSNRRIRTLTEP.Sl...DFNHSDDFTPlS........ssQKTLpLETSFVGNKHlEDTGSTPSIGENDLKFsKs.hG............................................................................	0	1	4	12
+14517	PF14666	RICTOR_M		Rapamycin-insensitive companion of mTOR, middle domain	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.	27.00	27.00	30.00	27.20	26.60	25.20	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.40	0.70	-5.34	51	266	2012-02-29 14:49:26	2012-02-29 14:49:26	1	27	232	0	188	271	0	212.50	34	15.33	NEW	hDDtpF+phlt-.opVLssK-apcWNWsllhpllcGPLhNsKRl-Esh..+ssKF....l+RLluFYR...Ph+hRFosl.hssc....s.......p+YlplGCtLhcsLLso.sEGh+hLt.cs..+llpQlucsLspl..........hsGhsstp.slFSpp+LpsTlstGYFthl.GsLSsstpGl..plLE+aphFshlhplhph.........p.s+..ssllpl.llssL......DYsh.supsRhlLsKALssusc.plRlaATchLthhlps	...............................................p-tthpphlh-.opV..Lpp.p.phhcWsWslIhpllcuP....h.hN.+.phc-t....phs+Fh+RLlsFY+......P.phpaupl.hstp.....s............ppaspsGCthhchLLpo..Eu.thhh...s.........cllpplsphLsps..................hoG.hps.p.lhspppltsTLsttYFhhl.GsL.SspspGl..phL-+hp........h........Fphhhplhph............................p..sc...scLlpL.llusL......DYoh..-u.h.s.RllLoKsLTsuoc.shRlaATchL+hhl.....................	0	62	101	155
+14518	PF14667	Polysacc_synt_C		Polysaccharide biosynthesis C-terminal domain	Bateman A	agb	Jackhmmer:C9L817	Family	This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.98	0.71	-4.40	347	5970	2012-10-02 21:24:20	2012-02-29 15:39:12	1	27	2511	0	1351	15273	3365	133.80	17	27.14	NEW	hLtlhuhshlhh.ulh.t.h.h.s....s.l.Lp.uhs+tphshhsh...hluhllpll.lshhL....l.........hG...h.........hGAuluTsluhh.l.s.shlt.h.hhlp+..h...h.p.hp....h.....h.t.p.hh...hth....h.hsuhlMslsl....hh.hthhh.....................t......sh...l...th....llsls...lGs...hl...Yhhhlhhh....ph	.......................................................h.hhshs.hlhh..u...lh.t...h...h.s....s...h..Lp.uh....s...c.p.+h.s...hh.s.h.....hh....u.s.l...l.p.ll..l...s....hhL........l............................h..a..G......h...........................hG.Aulu..T.h.lu....h....h....l....s....h...h....l.t.....h.....h...h....l..........p..........+..........h..............h.....t.....hp..........h......h.....h............h..............h....h..h...................h...h...h....s...h........h...h..h...h...h..h.............hh...h.......h.h...............................................................h.........h.....h........h.h.hhh....h.uh......hh....ahhhhhh...h.....................................................................................................................	0	455	917	1153
+14519	PF14668	RICTOR_V		Rapamycin-insensitive companion of mTOR, domain 5	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.	27.00	27.00	27.00	27.10	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-8.91	0.72	-4.05	32	251	2012-02-29 15:53:02	2012-02-29 15:53:02	1	30	216	0	185	260	1	73.00	41	5.33	NEW	lhcLKuuLWAlGal.GoophGlshLp...ptslltpllplAppsplhSlRGTsFasLuLIupTppGsclLpchGWpS	............hclKusLWAlGsl.GS.sphGhshLp..........pp..slltpIlclAcpspVhSlRGTsFaVLGLIu+TppGt-lLpchGW-.....	0	65	101	153
+14520	PF14669	Asp_Glu_race_2		Putative aspartate racemase	Coggill P	pcc	Pfam-B_34791 (release 26.0)	Family	This is a small family of vertebrate putative aspartate racemases. The family lies on TOPAZ 1 proteins.	27.00	27.00	28.00	27.50	26.80	26.50	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.47	0.70	-5.04	3	28	2012-10-03 04:39:14	2012-02-29 18:32:59	1	2	25	0	16	34	0	222.80	63	15.17	NEW	EAGhVhssEas-hl.hhLcphpssppElssslssKS...RupAosP+puaLs-LApsVVEVELCKcpEDWs+LGslFhSVCpGsccsu-LpRFCuCVAhALLcEsKD.K.uVPFstFAETVCQ-sppDElsKTaLGRIGVSLMapYHRTppWoKGRKVL-VLScLKlEFToLKGLFGsEcGASRCQLVTlAAElFIpSGSIEGALNsLR.ENEWFlSSSoWPCEpADVpsR+RVLstL	...................................................................EAGMlLDsEHFNYIVKLLYQlQASKQEIoAVLEhKS...RLphRQFKK..NWps...DLcSALsclEHCKEKGDWTKLGsLYlNlKMuCEKF.ADhQpFCACIAEsLTK-h.K-ERPslPFCEFAETVsKDPQNSc....lDK.s.lLGR.IGISAMYFYHKLLQWSKGRKVLDKLYELKIHFTSLKGLhGPEKLAsRCQIVNlAAEIFLKSGSLDGAIWVLR..ESEWIIsTPLWPCDRhDVLNRHNLLCTI..................................................	0	2	3	5
+14521	PF14670	FXa_inhibition		Coagulation Factor Xa inhibitory site	Coggill P	pcc	Jackhmmer CATH:3kl6_B_0	Domain	This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].	33.40	33.40	33.40	33.40	33.30	33.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.59	0.72	-3.83	204	5651	2012-10-03 09:47:55	2012-03-01 14:05:28	1	1176	167	166	3003	5435	0	36.70	41	5.65	NEW	Cphs..N..G..G...C.s....c..h..C.h..s.s.......s.s...........s..h.p....C.sCs..p..G.a.p.L.s........s.D..sp...o.C	..............Ct.s..N...G...G....Cp...+.h.Ch.ss.......s.u.................u..a.p...CsC...s..G.a.p.L.t......s.D..t+o.C..............	0	870	1089	1827
+14522	PF14671	DSPn		Dual specificity protein phosphatase, N-terminal half	Coggill P	pcc	Jackhmeer:CATH:1ohe_A_01	Domain	The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, Pfam:PF00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity [1].	28.20	28.20	28.60	28.30	27.60	28.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.67	0.71	-4.19	42	431	2012-03-01 14:48:06	2012-03-01 14:48:06	1	5	262	3	265	410	10	128.20	43	23.61	NEW	lEhIpsRLYasshpp.....pP+ss...sssaaFslDc..-LsYpsF....atDFGPLNLuhlY+astpLschLps...shppKplVaYou.hcs....c+RsNAAhLlusYhllhhshoPccAhpsl.pphp....s..sahsFRDAohusssaplolhDClpGlp+A	.....................................tphhhh.h....................pspss........shhaFslDc..pLhYpsF....atDFGPLNluhlYRassclpchLps............hshtcKtlVaYou.hDt......................+cRANAAhLlusYhVlhhshoPcpA.apsl.hpss....s..sahPFRDAuaGsssaplTlhDslpGlpKA........................	0	99	145	213
+14523	PF14672	LCE		Late cornified envelope 	Eberhardt R	re3	Jackhmmer:Q5TA76	Family	This is a family of late cornified envelope proteins that are expressed in skin [1].	24.50	24.50	27.00	24.90	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.13	0.72	-10.95	0.72	-3.50	10	255	2012-03-02 13:07:00	2012-03-02 13:07:00	1	2	22	0	94	230	0	71.30	56	80.19	NEW	sPPKCP....sPKCP...PKsss.Ch....PPsSSC.CussS..GGCsGs.............SuuGGCCLSHHR.RRSHRC.RhQSSsCC-pGu.....GQQSGGSGCCHuSGGCs	.........................sPKCP.....PKCP...P.pss......s.C.........PssS..SC..CusSS..GGC.Cu..s..................Su.GGGCCLSHHR..+Rp.+Rp..R.psSssCsp.................uG.u.S.uCstuuuGp...........	0	20	20	20
+14524	PF14673	DUF4459		Domain of unknown function (DUF4459)	Coggill P	pcc	Pfam-B_10980 (release 26.0)	Domain	This family appears only on sequences from Salmonella spp.  These sequences also all carry a YARHG domain, Pfam:PF13308.	27.00	27.00	45.80	45.70	23.20	18.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.00	0.71	-4.53	2	68	2012-03-02 13:31:19	2012-03-02 13:31:19	1	3	66	0	0	26	0	148.70	97	33.39	NEW	MKKCFLFIFhCLFIFSANAELKFRPEhENKKIYFQGKVTDYTLNDFhFFGDSREPFYGSENDDYTATADEWLtFYAELPDVRKWQRVVPDDFShM.GAPWCDIQFFEQENDHSVITGSEHhRCIDFLVTPKRKGLIPMGTKGTLhDYGSYLAFAPQIc+	..MKKCFLFIFVCLFIFSANAELKFRPEFENKKIYFQGKVTDYTLNDFTFFGDSREPFYGSENDDYTATADEWLGFYAELPDVRKWQRVVPDDFSTMYGAPWCDIQFFEQENDHSVITGSEHMRCIDFLVTPKRKGLIPMGTKGTLMDYGSYLAFAPQIKR.....	0	0	0	0
+14525	PF14674	FANCI_S1-cap		FANCI solenoid 1 cap	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein [1].	25.00	25.00	31.60	31.60	22.50	18.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.43	0.72	-3.91	5	57	2012-03-02 15:30:47	2012-03-02 15:30:47	1	5	31	6	20	47	0	51.90	63	4.80	NEW	MDQKILSLAAEcosD+LQEaLQsL+Es-LoslLTsQAVKGK-sGALLRAIFKG	..MDQKILSLAs-KTsD+LQEFLQTL+-DDLTsLLpNQAVKGKssGALLRAIFKG.	0	1	3	6
+14526	PF14675	FANCI_S1		FANCI solenoid 1	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein [1].	25.00	25.00	25.40	26.90	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.36	0.70	-5.00	16	138	2012-03-02 15:31:51	2012-03-02 15:31:51	1	23	93	8	82	125	0	194.60	35	17.27	NEW	pstp+Rhplspsslptlcss-Lshchs.DlIuRLhhDlssassppLlcls-hCl-ul........................RtG-spshsWK-LLPplLss......Lusp.tplshsshtloGsEY+cpllssLssh+WsspIlsslssMFRDlsLSpEEhphVlsKlsstlpc.ls..ElPPLsaQLhplC.psuupll..L.uLp+YFpcpahc+h.sptsopoo....Dl-sI.......................shSscELR-sEtTlLaHls.ssph	.......................................................................t...+Rhtlhp.hlph.hp..ssclp..c.st-llshLhh-htphPs...Lsplsp.hl.ssl...............................+.p.ushhssp.....h-LlPhhLos...........Lssp.pplsh.....s...t....st..lsG........pEhKcpllsslCo.scWst....ph.llplssMF+Dls..Lo.s-Elp.hVlpKllphhpc.lsLQElPPLVYQLLlLuoK.G.s+.+tl..LpGlltaFsphppp....ptp...ppp.s...sp.h.....-l...l.......................s.hst..tELRclEGTlllHlsaAlc.................................	0	29	38	60
+14527	PF14676	FANCI_S2		FANCI solenoid 2	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein [1].	28.50	28.50	28.90	29.60	27.90	28.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.60	0.71	-4.33	25	145	2012-03-02 15:32:28	2012-03-02 15:32:28	1	27	102	8	94	147	1	152.00	36	12.64	NEW	tllpulVphuFhLL-..........uttssptpsht.hpt.....................LGlplLhphF+hHphsRscIl-plhsRllsppsp.sspal...................cLLuhlspstshhllEpsuplp.....-hh-al.salssssuptllsAlhPLlKlS.tsl+DtlILVLRKAMas+-hssRhsAVsGalp	.....................................hVspGLVpLuFhLh-...................................uhssp+h.s.stshps..shtp...........................................LGtslLlchF+hHchhR.......p..cIl-plhsRllopsss....s.p.a.l....................................-LLupllhtsPhhl.psss+lp.....-hhDal.saLPhps..sptLlpAl.PLlKlS..hshRDuLILVLRKAMFup..ph...s..sRpsAVsGFl.h....................................................	0	34	44	72
+14528	PF14677	FANCI_S3		FANCI solenoid 3	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein [1].	25.00	25.00	25.80	25.90	24.80	21.80	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.21	0.70	-4.96	13	99	2012-03-02 15:33:04	2012-03-02 15:33:04	1	14	71	8	57	106	0	205.40	38	17.27	NEW	lLohphlScLLshLFcDssp.u+pEsLulLRSss-ah.RYuVsVslQKlQQLc-p..sDss-upssc+hFcpLCDIT+VLhhRhsshsssl.c-sG.....polSlLslEshhclhsslpppYss+hspFLpslDssssstpc...........slTppsthhI+pFQ+slhs.hs.us-DsFsuKpslhLlslLohLucpLsPuSsphs.QhhsWslplC+cpsl-DsuhsKGLl.sLLF	............................................lhshthlspLLphLacDsst.uppEslslLRSsp-Fh.+YslslslpKlQplcpp.....sshsptppsc+hFp..pLs-IT+VLhW.R..Y..TslPosV.E-sG++.KtcolSLLCLEG..Lpclhssl.pphYps+lppFLpul.....Dsssppspc.t.......hslsppsth.I+pF...Q..Rsl....h......s.LS...upc--F.sSK-sl.lLlslLosLo+hL-P..uSsphs.p....hhoWs.+lC+-ssh....-Dst..hsKuLh.sLLF.............................	0	15	19	37
+14529	PF14678	FANCI_S4		FANCI solenoid 4	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein [1].	25.00	25.00	66.30	32.60	24.40	23.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.40	0.70	-5.28	19	132	2012-03-02 15:33:39	2012-03-02 15:33:39	1	22	97	8	84	138	0	235.70	35	20.15	NEW	sshLpclupsltspLGslc..p-sps.....-pps..pauhlshcTAu.olhtlllup.lp+lL--V-Whls+hps.httsphs........psspsthtsshcshE+ulhtQLspllpslpcLspsslPsGush-slhKtLt+hYshLosLsKaYlphssspts...thsscFEcL.l+h.............sGopLsspsYshIoY......lpttpp-p.spppp.....p........tttspsthAKlLRET+.IPslIauIEpaEKalIpLSKKoKl..NLhpahKhSTsRDF+IpuspLcsAl	.........................................................h..hhpclupclpt.lGslc....pD.pl.........-pss...pashlshcTus.olhhhllup.s-csL--VDWlls+lKs.hstpphs........ptspsphph....tpshE+ulhhQLspllphhpcLlpsulPs.G...o.ssDsLLKtLs+hYshLosLsKaalpsppspts....hstph-+L.V+l.............oGpp..LTs.hYsFIoY.......................lpp...p...p.....p...pp...t..t....ttpt........................tt.ststhA...+lLR....ETK.IPsLIFsIEpYEKaLIpLSK......KoKl...............NLhpahKhSTuRDF+Ipss.Lp.sl..................	0	33	41	61
+14530	PF14679	FANCI_HD1		FANCI helical domain 1	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the helical domain 1 (HD1) of the Fanconi anemia group I protein [1].	25.00	25.00	25.20	29.20	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.65	0.72	-4.25	19	101	2012-03-02 15:34:20	2012-03-02 15:34:20	1	17	66	8	57	95	0	85.00	44	7.08	NEW	pLGREll+alKsst....tpsLsPFslulLLSVuplpRFc-plh-hL+oslh+sh+D.phppsu+WLpchl.ppssltshll-slpso	..........-LGREllKtLKssp..t.ssssLsPFSlALLLSVsRIp.RFpEQVhDlLKsullKuaKDhQlhpuSKaLpsLlPpc..s..sVushILEVV+NS.............	1	17	23	38
+14531	PF14680	FANCI_HD2		FANCI helical domain 2	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the helical domain 2 (HD2) of the Fanconi anemia group I protein [1].	25.00	25.00	35.80	30.60	23.90	22.70	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.36	0.70	-5.25	16	147	2012-03-02 15:46:03	2012-03-02 15:46:03	1	24	99	8	94	147	1	212.30	33	18.07	NEW	su.....Sp.sSp.tsshoQlplss+ophsss...sN.-sLsLEIlG.LRRCLsQQA-VRlhLY-GhY-slcpNupLusplLphLhsph+paa-s........-.DhlsPl+l-sClsupG-p...lhLpEPLu+LlpslspCLthhpps.sstss.s..............El..splLESlopRMl+s-..LEDFpL..........................Dcss-hs.pssssuhcpshhshhhhulhEsLIpaphht..sshscsph...cclLuLFcsYpKLs-hLKc	..................hs..spphSt.t..shSQ.splsspuphsss......tN..-shsLEIhs.L.RRCLsQQA-VRhhLY-GhhcllppN....s.pLusplhphLhs.p.h..+.p.a.acs..........c.DhlsPlKl.-tClh..........spusp.............l.LpEPLspLlpslppCLthhppt..shptt..........t.p...............h.pcl...........pphL..-ohspRMl+s-....LEDhpL.......................................Dcst...-hs.psos.huhcsphh.s.hlhulhElLl-aph.h.....sphscp..ph....cpll.sLF.papcLp-hhp...............................................	1	32	42	72
+14532	PF14681	UPRTase		Uracil phosphoribosyltransferase	Bateman A	agb	Jackhmmer:B0C7X6	Domain	This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.12	0.70	-5.12	113	5012	2012-10-10 14:25:38	2012-03-05 13:22:09	1	28	4240	67	1505	3471	1360	199.90	43	83.73	NEW	ls.s+PhlpthhohlRspsT.ssspFcthhcclsplLshEAhs.p..Lsh.p..pt..plp.....TPl......utth....s.s....h.h....h.st......plshVsILRAG.................................uMhpulpsl.hPs.s.plt+lhl.R.-c..pT..................hp..P.........aYp+LPppl........sppp..................llllDP...hlATGuoshtAlchL.hct...sst.ppIhhlsll......u....usp....Gl......pplttpaP..c.lc.lhsuulDppL..s.-puaIlPGLGDhGDRhFGT	.........................................................................................................................sHPLlpH.KLollR..-.p........c..T..uop..c..FRc..LssElupLh.............s.....YE...............so+..D..L........h..c.......cs...pIc.............TPh..........ut.sp...sp.....p.l............t..u+..........KlslVPIL...R.A...G..l................................G.Mh-.....Gl.L.p.l...l.......P...u.......A...+.......l.......G.......h.......l..G..l..aR....D.E....-T.............................................Lc..P.s.............Y.a...t..KL...P.p.cl......scRt...................................slllDP...MLAT..G............G.Sslt.........AlchL.Kc+......Gs.....ppI+hlsLl......A....APE......Gl......cslpc...u.HP.....D....Vc....l....asAul..DccL..N..-+......G.................Y.IlP.G.....LGDAG......DRlFGT...............................................	0	468	899	1262
+14533	PF14682	SPOB_ab		Sporulation initiation phospho-transferase B, C-terminal	Coggill P	pcc	CATH:1ixm_B_02	Domain	Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain, represented by this family. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate hereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor.	27.00	27.00	29.60	28.60	25.00	24.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.57	0.71	-4.29	12	140	2012-03-05 14:41:45	2012-03-05 14:41:45	1	1	137	10	21	74	0	113.40	51	61.89	NEW	hPphAthlLTaNWcs+.hpLEaEVLG-l+sLpth-ppLhshspplFshhcpuls.tsENHLslolphp..-......ptlplaFDFpGhls.shptlpp.hpp.tptp.thphhphcls-cEssl	...MPLFSEWILTYNWKQQPsLLEYEVLGc..L..+N.LS+hDEpVCTWosQFFSMLQHSLDVY..VENYVCITIEsDu........-NARFFFDFRGKLT..slEELQs.WLu.spNN..cahsISYoVRDEElSl..........................	0	5	13	15
+14534	PF14683	CBM-like		Polysaccharide lyase family 4, domain III	Coggill P	pcc	CATH:1nkg_A_03]	Domain	CBM-like is domain III of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain possesses a jelly roll beta-sandwich fold structurally homologous to carbohydrate binding modules (CBMs), and it carries two sulfate ions and a hexa-coordinated calcium ion.	27.00	27.00	28.00	27.80	26.00	25.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.08	0.71	-4.61	56	304	2012-03-05 16:42:11	2012-03-05 16:42:11	1	23	130	5	211	322	1	176.50	27	28.84	NEW	sslWcIG..DtossuFhsu-...............phhR.H...sc.schtshtsLsYTVGsS.tssDashAphpchs.......sshpIpFpLsssp.hs..tshTLRlulstA.........suucspVplNs...hsus......ssu..tshthDspshp+GsapGhhclYshslPuutLhp..Gs...NTlplssss..........uo......s.h..uhhaDslcL	.....................slWcIGhsD+oustFhhs-......................................pphRta....p..c...schhP.t.t.slsYTlGpS..tpDa.aup..hsths...........................ssapIpFsLssspht...tshsLclul..AsA..................ss..u..ch..pVp......lNs...sss...............hss.......ht.pcsshsc+Ghp.Gh...ht.....hap..hslsushLhpGs...Nsl.hls.sp..............us..........t....shhaDhlcL....................................	0	52	129	181
+14535	PF14684	Tricorn_C1		Tricorn protease C1 domain	Eberhardt R	re3	CATH:1k32_A_03	Domain	This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain [1].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.23	0.72	-4.10	129	801	2012-03-06 14:27:51	2012-03-06 14:27:51	1	45	538	24	226	719	107	69.70	30	8.07	NEW	ttEhpphFc-sWRhh+-p..FYss.....c.h+Gl.D..WpultccYp.hlsplsspt-hscllsEMlGELssSHshhpss	....................tEhtthF-csW+hhccp...F....ac......s..hpGl..D..WpultspYp.hlsphp...sp..p-.ht-lLsEhluELssuHstst...........................	0	99	185	216
+14536	PF14685	Tricorn_PDZ		Tricorn protease PDZ domain	Eberhardt R	re3	CATH:1k32_A_04	Domain	This domain is the PDZ domain of tricorn protease [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.81	0.72	-4.19	47	349	2012-10-02 11:12:46	2012-03-06 14:32:34	1	16	297	24	103	348	96	86.50	37	7.96	NEW	GhLGADhph.c..s..sp..acls+IlsG-shsscs+SPLstPGlplptGDhllulsGpslssstsPttLLsspuu..ptVpLolpss.su..ssRclsV	.................................GhLGA-lsts..s..ss..h+ls+lhsG-spsspttSPLstsGlslppGDlIlAlDGptlsss.......ss.htpLLpG..p.A.G..+.VpLolppsss....ttRplsl...............	0	39	75	94
+14537	PF14686	fn3_3		Polysaccharide lyase family 4, domain II	Coggill P	pcc	CATH:1nkg_A_02	Domain	FnIII-like is domain II of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain displays an immunoglobulin-like or more specifically Fibronectin-III type fold and shows highest structural similarity to the C-terminal beta-sandwich subdomain of the pro-hormone/propeptide processing enzyme carboxypeptidase gp180 from duck. It serves to assist in producing the deep pocket, with domain III, into which the substrate fits [1].	27.00	27.00	27.00	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.28	0.72	-3.87	51	306	2012-10-02 19:08:27	2012-03-06 16:19:16	1	22	139	5	207	340	67	90.20	27	15.07	NEW	pRGsVoGph....Ghs......st.s.hhVGhs.............spshQYWspAt.ssGpFslssl+sGs.YsLhsat.........u-hpst...ssslsVo.uusst.slush	.....................................tRGsVsGplh....th.................h.t.shVGht..tt........t....spshQaWsp.....sc....ssG.....p.FsIssl+sGs..YsLhsas.........su...hG-ath....psslsls.supsh..p....h..............................	0	50	125	175
+14538	PF14687	DUF4460		Domain of unknown function (DUF4460)	Eberhardt R	re3	Jackhmmer:Q8N3R3	Family	This domain family is found in eukaryotes, and is typically between 103 and 119 amino acids in length. There is a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important.	25.30	25.30	26.10	28.30	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.87	0.71	-4.32	31	156	2012-03-07 14:34:13	2012-03-07 14:34:13	1	4	113	0	111	150	0	103.70	33	20.81	NEW	hhppRphtssclpsAL+PFYhtVHPDhFsp.aPp.p+psNEcSLKhLsuaL-sLpp.t.......scstpLpFYlpcssssp..t........pa+hVplpl....s...ppD...........scphlpplLcsCsL	........hh...+thtsschtsALRPFYhtVHPDhFup.aPp...p+plNEsS.....LKtLssaL-sLpp.t.............shpstpLsFYl+pss....pst.................ta+hlphpL.....p........spc..............phl..llppCpL..............................................	0	44	61	90
+14539	PF14688	DUF4461		Domain of unknown function (DUF4461)	Eberhardt R	re3	Jackhmmer:Q8N3R3	Family	This domain family is found in eukaryotes, and is approximately 310 amino acids in length.	24.00	24.00	25.40	24.80	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.79	0.70	-5.09	24	123	2012-03-07 14:36:20	2012-03-07 14:36:20	1	6	90	0	86	118	0	275.60	30	57.36	NEW	cpsLssWLccsttpApp+tcsstsl+cElp+L+ppLspphsLpclpasCGWsltH..hpus..LpoLp+L..sp...ppsp.....hpsL+...s+sllFu.shoGlShpGc..VMLsosDVpcsWhcllcpls.pacth..lptlshhEptlSplLtsIpls+hchh..PthpsptYtspLpplhsultca..hsttth.p.hPps.Lpshplslpo-u..ushhl....usoGphllPuosssshLlsFlspphcpApc+hpcacp.pthEcpLhspChcphpLppLsKD-ulTs-pMIsssp+LLpt...........t............hpGlpLplopYYS..VhoDGsl...CIPW-Wc	....................................................................sLpsWLcpsttpAhp.+hcpshsl+pElp+LcptLsppLtLpDlpappuWslsH..hpup....LpoLpRL..uppp.p....hhpth+...GpsllFs..stoGhoh.Gc....VMLsohDV..ppWhchhcpls..pa.sh......ptl.hhEcplStlLtuIplshhc.h..Phhph.ptYhshLpthhspl.c......hh...h.........Ppo.Lps..h.....ph.llpo-t......hs..l..........pphGpF.lPs.sCssspL..Fl..pp.hpp.Apcphp+hpp.................phhEppLhptshcchpLppL.hK.-.sul....osspMlsCsc+Llp..........t.h...............shLpGhpLplo+aYS.....VhpDGsl...CIPWsap...........................	0	31	42	66
+14540	PF14689	SPOB_a		Sensor_kinase_SpoOB-type, alpha-helical domain	Coggill P	pcc	CATH:1ixm_B_01	Domain	Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, Pfam:PF14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.96	0.72	-4.41	56	2392	2012-03-07 16:11:40	2012-03-07 16:11:40	1	29	1272	10	403	1561	22	60.90	32	12.52	NEW	htt.th...ppllcsL.+ppRHDahN+LQlIpGhlpLs+h-+spchIcplspchppp.ucl.spl	.....................ph...tpLstlppYs-uL.RspsHEahN+LpslhGLLplppY...-...cl....h....phlpptspt.Qp.........h.t..................	0	139	263	333
+14541	PF14690	zf-ISL3		zinc-finger of transposase IS204/IS1001/IS1096/IS1165	Coggill P	pcc	IS-finder, manual	Domain	\N	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.23	0.72	-3.93	135	4025	2012-03-07 16:36:10	2012-03-07 16:36:10	1	22	1094	0	544	2757	127	47.00	38	15.25	NEW	pshtCPpCG........pps...hhtpsp.pppph+.clshtsptshltlc.ppRapCp...p..C	...........p.sssCPcCG..........sph....t+hchp...+so+Is.hLcs.sG.hPohlhL+...KRRF+Ch...p..C..............	0	144	375	439
+14542	PF14691	Fer4_20		Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	Coggill P	pcc	CATH:1gte_A_02	Domain	Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyses the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds [1]. This domain carries two Fe4-S4 clusters.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.44	0.72	-11.01	0.72	-4.44	327	6849	2012-10-03 08:56:43	2012-03-07 16:55:41	1	286	3369	26	1619	4929	2276	110.70	35	17.58	NEW	Rtps.F.pEVshGaotc.pAhtEApRCLp.....C....t.ss...Ch.p.....uCPlslsIPpFIctltpGs......hptAhchIppsNsL.PulCGRVCPQEp.CEus.....Clh........t.....p..s.p....PVsIGpLERaluDhthpp....sh	...................................................h...t.a..Eh.....s.h.s..t....ps...t..pus.R..C..h..p....C..........s..ss.......Cp..p............uC....P....l....pst....I...Pp...a...lcLl..t.....cuc..............h.ppAhch....lp.p.........TNsh.P.t.lsG.RVCPps..CEuu.....Csh.........s....s.p..s............sVsItslE+alsDpuhp.s.h................................................	0	581	1077	1386
+14543	PF14692	DUF4462		Domain of unknown function (DUF4462)	Eberhardt R	re3	Jackhmmer:A8MTB1	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length.	25.00	25.00	35.40	25.90	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.61	0.72	-7.06	0.72	-4.69	24	153	2012-03-08 11:34:24	2012-03-08 11:34:24	1	11	7	0	148	149	0	26.80	66	21.88	NEW	uAKSR.sWNhLPRAusl.......GIGCQEQVQLE	....sAKSRhsWNhLPRAGsl.......GIGCQEQVQLE....	0	148	148	148
+14544	PF14693	Ribosomal_TL5_C	ShortName;	Ribosomal protein TL5, C-terminal domain	Punta M	mp13	CATH:1feu_A_02	Domain	This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, Pfam:PF01386. Full length (N- and C-terminal domain) homologues of TL5 are also known as CTC proteins. TL5 or CTC are not found in Eukarya or Archaea. In some Bacteria, including E. coli, this ribosomal subunit occurs as a single domain protein (named Ribosomal subunit L25), where the only domain is homologous to TL5 N-terminal domain (hence included in family Pfam:PF01386). The function of the C-terminal domain of TLC is at present unknown.	27.00	27.00	29.80	28.70	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.84	0.72	-3.78	195	2672	2012-03-08 13:20:59	2012-03-08 13:20:59	1	2	2591	91	749	1875	2003	88.30	28	43.06	NEW	EclplcVPlphhG..-...usGhp.t.G.Gllpp.hpplplpsh.PsslP-plpVDlssL.c.l.GsslpluDl..p..l..P...p..G..lpl.s.......s.....-...s-t......sllolssspstc	................plplcVPlphhG..c...usGlK.p.G.GllppshpplcVpsh.spslPEtl-lDlosL.c.l.G.cslpluDl..p..l..P...p..G..lpl.h...............s..c...s-.......slsslhtsp.........................	0	274	534	658
+14545	PF14694	LINES_N		Lines N-terminus	Eberhardt R	re3	Jackhmmer:Q8NG48	Family	This family represents the N-terminus of protein lines [1]. In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator [2-3].	25.00	25.00	27.70	27.70	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.26	0.70	-5.17	9	107	2012-03-08 13:57:56	2012-03-08 13:57:56	1	4	78	0	67	108	0	284.60	32	45.46	NEW	hslohsDsESa.DooplKs.slKtLts+WssLlcth.spllpp.........ssspstsslloFLcLWEslISV..KANLSlh-T+PFaupLsphlhLLssslsshla+phLsLFN........EsLCYGSTLALQ-...hLs--ssuLActll+sV+chRlL-pLPhpptsu.................................phuuupus............sshD+sLLQKMuLLVLKSlAlpl+EhR.ssSSDSSlcSpc.D..t-hthIpRSIR-VLppL-salKspLpFHP-sphuchLl+lFtDQDD.hlEAMVCoLDltsGloa.cssAsssLs.........th....LNPshoFltFL+hluaDocVLLDhLlSsETCFLLYLLRaLKalRcNWshFlpsCt	............................................................................................................................hlshh.pE.h..Dost.Ks...hlpph.p.asshhcsh.splh.s.p.............tsth.p.lhsFL.pLhE.llus....thpLpht....pp+.hahp.sth..ll.sh.s.l.shlh+phlhhhp........EsLsh..G..S..s...s..L.s.......hls.-hhtLAptllptV.shthLcplshpt..s.....................................hGsspst...st..t..t.DpslLpthsLlllKSltlphp....sso.S..ssp..........hc..s............lpp.hpclLthL.c.hlp.php.p.......p.schl....plF....-QDDphlEuhhs.Lslh.....t...lsh..ttps.h...pLs.......................th.........hNPhhhFl.hLc.huasss.lL.LDhLlSsE...TC..FL.YhlRaLKhlpts.Ws.Fhp.C................	0	21	27	46
+14546	PF14695	LINES_C		Lines C-terminus	Eberhardt R	re3	Jackhmmer:Q8NG48	Family	This family represents the C-terminus of protein lines [1]. In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator [2-3].	27.00	27.00	37.70	36.80	21.40	19.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.76	0.72	-4.71	20	93	2012-03-08 14:10:50	2012-03-08 14:10:50	1	4	76	0	64	97	0	38.70	47	5.50	NEW	cshssLlcL+huIpRLhpKsLFPYNssPLLR..LLcpsEpL	.....cshpsLhcLphsIsRLppKsLFPYNsssLL+..LLcphEsl.....	0	17	24	42
+14547	PF14696	Glyoxalase_5		Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal 	Coggill P	pcc	CATH:1cjx_A_01	Domain	This domain is one of two barrel-shaped regions that together form the active enzyme, 4-hydroxyphenylpyruvic acid dioxygenase, EC:1.13.11.27. As can be deduced from the disposition of the various Glyoxalase families, _2, _3 and _4 in Pfam, Pfam:PF00903, Pfam:PF12681, Pfam:PF13468, Pfam:PF13669, these two regions are similar to be indicative of a gene-duplication event. At the individual sequence level slight differences in conformation have given rise to slightly different functions. In the case of UniProt:P80064, 4-hydroxyphenylpyruvic acid dioxygenase catalyses the formation of homogentisate from 4-hydroxyphenylpyruvate, and the pyruvate part of the HPPD substrate (4-hydroxyphenylpyruvate), derived from L-tyrosine, and the O2 molecule occupy the three free coordination sites of the catalytic iron atom in the C-terminal domain. In plants and photosynthetic bacteria, the tyrosine degradation pathway is crucial because homogentisate, a tyrosine degradation product, is a precursor for the biosynthesis of photosynthetic pigments, such as quinones or tocopherols [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.70	0.71	-4.24	17	1091	2012-10-02 15:00:03	2012-03-08 15:28:49	1	6	816	6	336	996	193	140.50	36	33.00	NEW	FENPhGl-GFEFVEFuuP-..s..ttLcslFctMGFTtVA+HRSKDVsLYRQGsINFIlNtEPcS.AthFup-HGPuACuMAFRV+D.AppAYccAl-hGApPlpht.sGsMELplPAIKGIGGuhlYLlDRas-us..........SIYDlDFE	................................................hthsGhEFlE.F.s..s..ss...s...pp..Lt..t.la.p.p.h.GFstl......A......+......H......Ro...K..s..l..h..La..RQG....s..Ishll.......N......u................-..P...c..S....h..AppF....s...p..pHGPulCuhAhRVcD.AppAap+AlphGA....t....s....h....p....s....t....s....u....s.t....E....Ls......l....P.A.I.p.G.l...GsSllYhVDR..h..tt..t..........slY-.DF..........................................................	0	72	164	254
+14548	PF14697	Fer4_21		4Fe-4S dicluster domain	Coggill P	pcc	manual	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	35.00	35.00	35.00	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.04	0.72	-4.11	63	3437	2012-10-03 08:56:43	2012-03-08 16:17:41	1	136	2521	25	833	2684	375	57.90	41	22.32	NEW	AhIcp-tCIsCs+CahAC.DsuapAI.......t..h...s..sc..p.....t..h.......s......l.l...p.-.-.CsGCsLCsslCPl...-CIsM	...........................hIsp-pCI......G...Cs.p..Chp.A.CP.......l.cAI..........................h.....s...s.c...p........h...p.................................s......l.h....s..-..pC.s.G..CpLCsssCP..s..cCIp.............	0	245	478	670
+14549	PF14698	ASL_C2		Argininosuccinate lyase C-terminal	Eberhardt R	re3	CATH:1k7w_A_03	Domain	This domain is found at the C-terminus of argininosuccinate lyase [1-2].	24.00	24.00	24.40	24.10	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.29	0.72	-3.90	617	4020	2012-03-09 08:50:06	2012-03-09 08:50:06	1	16	3666	53	1083	3103	1579	70.50	40	15.17	NEW	assATDLADYLV+.+.GlPFR-AHclsGphVt......hu.pcs..hs.Lp-LoLc-hpp....h.....s......shl.......s.p....D...lap.sLsl-suVsp	...........ausAT-LADYLVpK.GlPFR-AHclVGcsVh..............huhppG....hs...Lp....-...LsLp-hpp........h.........s......shl...............s..p....D........lap.lLshcsslp.....................................................	0	329	677	908
+14550	PF14699	hGDE_N		N-terminal domain from the human glycogen debranching enzyme	Godzik A	adam	Jcakhammer:GDE_HUMAN	Family	this domain is found on the very N-terminal of eukaryotic variant\	     of the glycogen debranching enzyme (GDE), where it is immediately  followe by the aldolase-like domain. The eukaryotic GDE performs  two functions: 4-α-D-glucanotransferase (EC 2.4.1.25) and  Amylo-α-1,6-glucosidase (EC 3.2.1.33), performed by the,  respectively N- and C- terminal halfs of eukaryotic GDE enzyme hGDE_N domain is involved in the glucosyltransferase activity,  probably\	    as a substrate binding module (by analogy to other  glucosyltransferases)	22.10	22.10	22.70	26.40	21.30	20.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.97	0.72	-4.14	68	237	2012-03-09 12:36:43	2012-03-09 12:36:43	1	12	206	0	168	232	0	94.70	30	6.56	NEW	pLRFt..G.u.S.lsRcGslasNhPtsup..pFcRsp..apphclp.............s.......s...........hspshplclslppsGuFsaYhsY.......................csp........cosphYhsVsPtLplsu	.........................LcFt..Gs.S.lu+psslaoNh.....P.......pGp..pFpRsc..F+phphp................s............s.................hspchhhcl.s.lppuGuFpaYhsa..........................sspt......tcosshYlsVsPtLpls.s............	0	45	81	132
+14551	PF14700	RPOL_N		DNA-directed RNA polymerase N-terminal	Eberhardt R	re3	CATH:1msw_D_01	Domain	This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme [1]. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex [2].	25.00	25.00	27.60	25.90	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.02	0.70	-5.17	126	554	2012-03-09 13:37:42	2012-03-09 13:37:42	1	14	381	20	280	574	278	279.60	19	28.13	NEW	p+QhpLEpcuh..ctAhc+a+cthc....chpcp.uh..shsh........lpslhhpWapsLtstlpc-hc...............h..........................................ptppptpstassaLp....................hlss-chAsITlppllshhs.sts..httsh...................plsphshslGculEpEhchpphhcp........t.p.........ppppttpp.................................+php............phlcppphpt...........htthhttt................................................Wspss...ps+lGuhLlphLhc.s........uhlpsst.......tssts..........t..PAFhHthph.........sp+h.Ghlchsstlhch.....lscpstt..h......s.ah......P....MllsPcPWs..uhspGGYh.hht...o.lhRs+ss.........tppphhhpshpp.splp.......pVacuLssLGp	...................................................................................................................................................tQhthE..psh..ttuhtchpp..p.......ph.ph..t........h......hpthhhpWht.lhttlppphp........h..................................................................................tttttp..hhsalp....................hlsscp.h...u.hlshhphhthhh.stt...................................................phhphhhtlGptlpp-hph.pphhpt........................t.p.h........t...ppt...t............................................pthh.....phhptt.t.tt....................................................................................................W.s.t...th...phclGshLlphLlp.s.........shlphpt.........tt..s...............................................t..sshhp.hph.t.............spph..shlchps.lhph......l....pppsh...............s.hh.......PMlsPPpPWs..u.hppGG..Yl..ht.........stlhRspt...........ppp.hhtthtp...sp.hp.......tlhcuLshLup..................................................	0	86	164	238
+14552	PF14701	hDGE_amylase		glucanotransferase domain of human glycogen debranching enzyme	Godzik A	adam	Jackhammer:GDE_HUMAN	Domain	this is a glucanotransferase catalytic domain of the eukaryotic  variant of the glycogen debranching enzyme (GDE).\	\	The eukaryotic GDEs performs two functions: 4-α-D-glucanotransferase  (EC 2.4.1.25) and Amylo-α-1,6-glucosidase (EC 3.2.1.33),\	performed by the, respectively N- and C- terminal halfs of  eukaryotic GDE enzymes. hDGE_amylase domain is a catalytic domain responsible for the glucanotransferase function. It belongs to the  alpha-amylase clan and is predicted to have a structure of a 8  stranded alpha/beta barrel (TIM barreal) where strands are  interuppted by long loops and additional mini-domains. In most other amylases, the catalytic domain is followed by a beta- barrel substrate binding domain, but presence of such domain cannot  be verified in the human (and other eukaryotic) GDE enzymes	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.38	0.70	-5.57	65	321	2012-10-03 05:44:19	2012-03-11 07:14:19	1	22	258	0	228	1087	85	363.10	35	27.98	NEW	c.LPLsulsl.oVlSKahGs.h..s.-W-c+lpsluc+GYNMlHFTPLQpRGtSNSPYSIaDQLpaDsshFss.......s..p........pDVpphlc...chcc-..aulLSlTDVVaNHTAsNSpWLpEHPEuGYNhpTuPHLcsAhELDssLlcaScpL.....pph.G..LPsplco.p-DLtplhssl+pcVlspl+LWEaYslDVccsscphhctap...........ssp.........s.shs...p...s............................s.hpp.pt.....ph...............lpc..t............hhp....RaupclDsp....h....sh....sl.hsph.....tps....ssc......h...cpstp..phpclL-clNlshYcEaDsDlppIlpplhsRI+YhRl--cGPKLGs.loccsPLlEsYFT.+..h.p.pt.p.............ptpphsLANNGWlWs.usPLhDFAu.sp...S+uYLRREVIVWGDCVKLRYGspP-DsPaLWc+MscYochhA+hFsGFRIDNCHSTPLHVAEalLDtAR+VpPsL	...............................................................t..lPLsslsl.ohluKhhG...h....s.cWc....p....cL.phhpc...pGY...NMl...HF...T...P.l......Q.........p...h......G......t......S......p.........S..sYSlhDQLphssphh.s............................sp...........p-l.tphlp...ch...cpc.....aslLsloDlVhNHT.AsN...SpWLp...-...HPEs..uYNhhsu....PaLp....sAh.LDptLhphuppl....................pph...GlP.s....l.cs..p.cl.........tlhphltpplhsplcLWE..aa.l-Vppthp.thhp.hp...ptp.............p.....p...........................................................s..p..hph............lpp.................hpRhsppls.p.h....sh....thh..h........ttt.......st......ppstphhpphlctlN..hhpphp.t.chp...............thlpplhsplpY.RlsspGP+lG..lopc.p.P...LhptY...FTh..tp..........................pttphhhApNGWlhs.sssLhshAt.st...SpsYLRRElIsWGDsVKLRYG.ppP-DsPaLWpaMpcYschhAphFpGhRlDNCHSTPlHVuEahLDtARclpPsL................................................................................................	0	81	124	184
+14553	PF14702	hGDE_central		central domain of human glycogen debranching enzyme	Godzik A	adam	Jackhammer:GDE_HUMAN	Domain	this is a central domain of the eukaryotic variant      of the glycogen debranching enzyme (GDE). The eukaryotic GDE performs   two functions: 4-α-D-glucanotransferase (EC 2.4.1.25) and  Amylo-α-1,6-glucosidase (EC 3.2.1.33), performed by the,  respectively N- and C- terminal halfs of eukaryotic GDE enzyme The hGDE_central domain follows the glucanotransferas domain and  precedes the glucosidase (GDE_N) domain. It is very likely that the current definition contains two or more domains, by analogy  with baterial GDEs, this domain should be involved in substrate  binding either for the N-terminal glucanotransferase  and/or the the C-terminal glucosidase (or both) 	19.80	19.80	20.70	20.40	18.80	17.30	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.78	0.70	-5.21	58	283	2012-03-11 08:10:09	2012-03-11 08:10:09	1	19	228	0	207	282	0	236.10	34	16.88	NEW	GIuslKphLNcLHpphupcua-.....EsalHp.-scaIslpRhsPcTp+GhhLlA+TAFssssss......tslsP.lpLsG.opschlhuhpL......pttssp..........c............hhpDcphLpGlPsplh-lps.............th..pt.tppstlhh..psFsPGSIhlFcTplssss....t.Lcp.l..................................hps..ustcAhspLsLhDLNhlLYRC-sEE+D..ss.Gps...GsYsIPs.aGpLVYsGLQGWhSlL.cpIhtpNDLGHPLCspLRpG..pWAlDYllsRLp	.................GIhssKphLNplHpphutcGas............psalcp..-sphl.sVpRhpPpo+puhhllA+TA.Ftsspss......ttlss.hpl..sG.phtchlhphpl.........t.p.ssp..........t........................hhpDpphlpGlPsh.hhplpt.h..........hth..ps.tp.sp.h.hpphsPGSlhlFcsplss...ts......s.Lpp.l....................................hpp..shtph.hsp...LsLh-.LNhlL...YRC-sEEp-.s..ttsGsYsIPs...aGtLsYsGLQ..........GhhSl.L.pcIh....p.NDLG..HPlCs.NLRsG..pWhlDYlssRL...................................	1	73	112	168
+14554	PF14703	DUF4463		Domain of unknown function (DUF4463)	Godzik A	adam	Jackhammer:Q9P1W3	Domain	This is a cytosolic (predicted) domain present in integral membrane  proteins, such as TM63C_HUMAN TRANSMEMBRANE PROTEIN 63C. This domain usually preceeds a DUF221 (PF02714)domain and follows  a RSN1_TM (PF13967) Fold recognition programs consistenly and with high significance  predict this domain to be distantly homologous to RNA binding  proteins from the RRM clan.	22.80	22.80	22.80	22.80	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.76	0.72	-3.46	198	880	2012-03-11 09:12:07	2012-03-11 09:12:07	1	21	225	0	638	834	0	88.20	22	10.30	NEW	lsp.sspcLpcLlccRcphhppLEtshsch...h+ps.p....th.ptps..ptph..........................................t....hh..shhs..cKVDuI-ahppclpcLs	.............................................................................................lshsspcLtcLscc.RcchhppLEth.sch...h+psp.....th.ptcs..ptph................................................................................................................................t..........hh..shhu...c+VDuI-ahppclpcL.....................................................................................................................	0	150	321	507
+14555	PF14704	DERM		Dermatopontin	Eberhardt R	re3	Jackhmmer:Q07507	Family	Members of this family mediate cell adhesion via cell surface integrin binding [1]. They also induce haemagglutination and aggregation of amebocytes [2-3].	23.00	23.00	23.40	23.00	22.90	18.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.01	0.71	-11.30	0.71	-4.25	29	166	2012-03-12 10:48:15	2012-03-12 10:48:15	1	26	61	0	112	165	2	137.80	28	24.10	NEW	NsacpshsapCssspulsslpShasN.tppDRRWsFsCsshus.t.ss.sssphsu...hNp..acpshsasC.....ssNhalpuhpStassstc......DRhWpatCpch..sss...ph..psCh.ps..sahNsacsslsas...........................s...ssspsIsGltS................hasss..pcDRcW+hpsCpl...sC	..................cpshsapCsp.spslstlpShasp.ptpDR...Wsa..t..Ctssst......tp.....ssp.shhp......lNp.....hs......tthshsC.....sss.thlsGhpSha..ssh..............DRcWpFhCsch..sst..................sshsCh.to..sasN..p.aspphshh...........................s.s.shhlpGhto.....................................hasss..pcDRpWpahh..Cph................................	0	78	82	94
+14556	PF14705	Costars		Costars	Eberhardt R	re3	Jackhmmer:Q9P1F3	Domain	This domain is found both alone and at the C-terminus of actin-binding Rho-activating protein (ABRA). It binds to actin, and in muscle regulates the actin cytoskeleton and cell motility [1-2]. It has a winged helix-like fold consisting of three alpha-helices and four antiparallel beta strands. Unlike typical winged helix proteins it does not bind to DNA, but contains a hydrophobic groove which may be responsible for interaction with other proteins [3].	24.00	24.00	24.80	24.20	23.70	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.44	0.72	-3.99	49	232	2012-03-12 11:46:56	2012-03-12 11:46:56	1	6	126	2	163	217	1	77.80	45	36.18	NEW	hpVpcEltpLsphIcchGp........p..sss.GphsVpFGhLF..-phssl.-........t..LVGsLhsA+K+plVcF-GEhLhQGtcDcVsIsLL	..................................plp+EltpLsp.IcphGp.......c.stD..GphpVpFG.LF..-+hspI...-........t......lVGhLhtA+K+clVsF-GE.hLhQGtcDcVsIsLL..................	0	52	71	117
+14557	PF14706	Tnp_DNA_bind		Transposase DNA-binding	Eberhardt R	re3	CATH:1mus_A_01	Domain	This domain occurs at the C-terminus of transposases including E. coli tnpA (Swiss:Q46731). TnpA encodes a transposase and an inhibitor protein, the inhibitor only differs from the transposase by the absence of the N-terminal 55 amino acids, which includes most of this domain [1]. This domain consists of alpha helices and turns, and functions as a DNA-binding domain [2].	24.00	24.00	25.50	24.50	23.20	22.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.68	0.72	-4.25	54	483	2012-03-12 14:11:11	2012-03-12 14:11:11	1	8	172	5	115	435	60	55.90	43	15.95	NEW	sWAppEhtpssLGDtRhscRLlplsppL..uppPstSlPpusp.shApscAAYRFhsNppl	.....tWApcphupAcLGDsRRs+RLlsLussL.......Ap+sGhSIspusp.shApscuAYRhlcNspV..............	0	23	63	79
+14558	PF14707	Sulfatase_C		C-terminal region of aryl-sulfatase	Coggill P	pcc	CATH:1auk_A_02	Domain	\N	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.93	0.71	-3.86	86	772	2012-10-03 20:55:17	2012-03-12 17:14:39	1	9	252	8	368	739	322	119.10	24	23.28	NEW	Ss+c.....hlFaYsust.............LhAVRhtp.......aKAHahT.shtspss..........................s.s.st.tlptH-P.PL.LFcLspDPuEphPL................ssps....spatpllpp.......lppshcpHppol.........s.s.sQhshhs.....hhhPhhpstp..h...s.ss.C	.................................+c..l.Fa.Y.s.sst.............LhAlRhtp.........aKsa...Fho.th..pspst....................................hhtp..hsppcs..PL...lFcLppDPtEph.s.l.................ssts..............s.a.ph.ltp.......hpthhtpa.psh...................h.........................................................................................................	0	105	153	227
+14560	PF14709	DND1_DSRM		double strand RNA binding domain from DEAD END PROTEIN 1	Godzik A	adam	Jackhammer:Q8IYX4 	Domain	A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)   	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.55	0.72	-3.69	24	349	2012-10-02 17:51:51	2012-03-13 07:27:26	1	29	109	0	202	525	123	73.20	32	9.36	NEW	psAsphLcplCpKNpWGpPhYplp.ppsGPcthhh.FhYKVhlPuhss...s....h...sschsssh--AKphAAphsLppLs	......tssphLp-lCpKppWssPpahLh..pssGPcppph.Fla+Vhlsuhsh.......................hh..sschpsthcpAKphAAphsL.tL.......................	0	40	70	122
+14561	PF14710	Nitr_red_alph_N		Respiratory nitrate reductase alpha N-terminal	Eberhardt R	re3	CATH:1q16_A_01	Domain	This is the N-terminal tail of the respiratory nitrate reductase alpha chain. The nitrate reductase complex is a dimer of heterotrimers each consisting of an alpha, beta and gamma chain. The N-terminal tail of the alpha chain interacts with the beta chain and contributes to the stability of the heterotrimer [1].	24.00	24.00	24.30	25.30	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.01	0.72	-3.71	73	1502	2012-03-13 09:33:31	2012-03-13 09:33:31	1	5	1099	12	150	902	20	37.10	58	3.07	NEW	HFLDRLpaFp+t......p.-sFusGHGtsssEsRsWEcuYRpRW	......+hLDRhRYFKp+.......s.ETFADGHGQlhpssRDWEDuYRpRW.	0	32	70	112
+14562	PF14711	Nitr_red_bet_C		Respiratory nitrate reductase beta C-terminal	Eberhardt R	re3	CATH:1q16_B_03	Domain	This domain occurs near the C-terminus of the respiratory nitrate reductase beta chain. The nitrate reductase complex is a dimer of heterotrimers each consisting of an alpha, beta and gamma chain. This domain plays a role in the interactions between subunits and shielding of the Fe-S clusters [1]	27.00	27.00	28.70	28.60	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.87	0.72	-4.46	141	1906	2012-03-13 09:34:22	2012-03-13 09:34:22	1	7	1444	12	235	921	18	80.90	52	16.13	NEW	LSPlhssspussh.....s......slhPslcsLRIPlcYLANLhTAGDstPVttuLcRhhAMRuYMRupslstp.D...tslhcpVGLotp	.................................LSPIpShs-AGsh...sss..............ulLPsl...-oLRIPVpYLANLLTAGDTtPVhpAL+RMhAMRpYMRupsVcs....hsD....spsl-cVGLot.t...............	0	59	130	189
+14563	PF14712	Snapin_Pallidin		Snapin/Pallidin	Eberhardt R	re3	Jackhmmer:O95295	Family	This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion [1]. It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting [2]. The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles [3].	25.50	25.50	25.70	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.17	0.72	-3.68	53	266	2012-03-13 14:00:15	2012-03-13 14:00:15	1	10	143	0	176	242	0	88.10	27	51.76	NEW	tptLupG..lhplhpPslcphcsplppltpsQppLtpplcpLspcLcchpc.pp.s.s..hshsp.YhpKLhsl++clhslpphlpplpcRht+lpp	...................h.p.lupG..lhshhtPslpphcpplpplpps........QstLhppl-p.s....sc...Lpchpp.tphs.h..hshsp.YhpKLhsl++chhhlpphhpplpcR.htcLp...........................	0	61	86	132
+14564	PF14713	DUF4464		Domain of unknown function (DUF4464)	Eberhardt R	re3	Jackhmmer:Q6V702	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 224 and 241 amino acids in length. There is a conserved YID sequence motif.	27.00	27.00	53.90	44.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.45	0.70	-4.95	44	173	2012-03-13 14:47:19	2012-03-13 14:47:19	1	4	102	0	115	188	5	188.30	38	93.70	NEW	hhs.slhpFsTYEDYLDShlo.pDhhYLpspclsRpLlc..LG.aRssupllpR-EFttp+pthctthps...................plsuh...Gcpl..pst.PhLpALApREchshstcLoTIIFlc.css+GpEISGYIDasppL+s..........psacshFpG+++........LhPpsoDLSaaNWcoppshhNsSsNapVls-st.pGLlF+pKtD+KlIsVssps..s.u-NspRsh.lposhYspVVlYDHhsR++s	......................lhpFtsY--YLcS.lo..DhhYLtspphh+pllc..LG.h+sptphhpc--F.tt+ttht.th.s................................htt........up.h..ps..shLhtLAtREc.shptpl...............ooIlFlp.pspp.G.ElSGYIDasppL+p............psacshFpt+++........LhPp.sDLSaasWcsphsh.NsosNa...........pVlscs....GLlFppKtD+KhlsVsspt....ucNspRp..l..o..Yh.slhaDHhhR+p..........................................	0	45	55	85
+14565	PF14714	KH_dom-like		KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	Coggill P	pcc	CATH:1mky_A_03	Domain	The KH-like domain at the C-terminus of the EngA subfamily of essential bacterial GTPases has a unique domain structure position. The two adjacent GTPase domains (GD1 and GD2), two domains of family MMR_HSR1, Pfam:PF01926, pack at either side of the C-terminal domain.  This C-terminal domain resembles a KH domain but is missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2.	25.30	22.20	26.70	23.70	25.20	22.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.45	0.72	-4.02	596	4526	2012-03-13 15:50:54	2012-03-13 15:50:54	1	12	4425	2	1039	3025	1279	80.60	40	17.34	NEW	RlsTupLNchlpcslttp..s.PP.s...p...G.+c....lKlhYsTQ......ss.spPPsFllF...sNp..schlptoYpRYLcNplRcsF.sh.pGoPl+lhhR	.............................RlsTuhLNcllppA..lttps.PP.s..p...G..+R...lKlhYAoQ.......su.spPPsFVla...sN.p.schlp.SYcRYLpNplRcs.F.sh.pGTPI+l.h+................	0	365	699	892
+14566	PF14715	FixP_N		N-terminal domain of cytochrome oxidase-cbb3, FixP 	Coggill P	pcc	Pfam-B_28684 (release 26.0)	Domain	This is the N-terminal domain of FixP, the cytochrome oxidase type-cbb3. the exact function is not known.	24.90	24.90	26.00	25.30	23.80	23.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.82	0.72	-4.57	213	1066	2012-03-13 17:05:29	2012-03-13 17:05:29	1	15	961	0	306	849	102	52.10	41	16.65	NEW	tssspsoGHsWD...G....IcEhsNPLP+WWhahFhhTIlaulsYhlh.YPuhshhpuh	...........stpspssGHpaD...G.....IcE.hs.....NPLP+WWhhhFhsTIlaAlhYhlh.Y.Puhu.hpu.h.........	0	83	189	248
+14567	PF14716	HHH_8		Helix-hairpin-helix domain	Coggill P	pcc	CATH:1bpe_A_01	Domain	\N	30.00	30.00	30.10	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.15	0.72	-3.79	351	1491	2012-10-03 02:11:09	2012-03-13 17:38:04	1	43	1116	210	618	1303	285	67.70	29	13.24	NEW	Npcl..s.phL.pclAphhEhpt....ts..sa.+spAY++AApslcs.h.sp.slss...h...pt...tl.....pp.lsGlG...cslApcI.pEhlp	....................ppl.h...chL.cplAphhEhpt....ts..sa+lpAYR+AApslcs.h.sc..slsph....p-.........h........pp.lsGI.G......cphAphI.pEhl...........	0	202	354	498
+14568	PF14717	DUF4465		Domain of unknown function (DUF4465)	Godzik A	adam	JCSG structure SP13250B	Family	A large family of uncharacterized proteins mostly from  human gut bacteroides, but also some environmental  and water bacteria (Planctomycetes) as well as  metagenomic samples Most proteins from this family are secreted or  located on the outer surface and may participate  in cell-cell interactions or cell-nutrient interactions This function is supported by a solved structure of a Bacteroides ovatus homolog, which adapts a galactose binding (jelly-roll) beta barrel structure	25.00	25.00	63.10	62.60	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.50	0.71	-3.86	22	101	2012-03-13 22:58:36	2012-03-13 22:58:36	1	7	65	1	16	68	17	185.20	31	39.28	NEW	ssY......spaG.......t.h......uGauhostT-ss.....ossass...p.huuhsGtGps....sssh.hh....s.sas.uhst...shlth.........sshphcGhalTNooYshhshhpGssh.........ut.......tshp..c.s.DaFplolhGa..c.....ss.....ssl-hhLADaR..ssp...p.lVssWpahDLosLusssplpFphpSSDs..Gp.aG.hNTPuYFslDsl	......................h....sphG...t.....s.uuashSthsp.t......sssass...p.hus.h.....sts.Gps.......Gs.sa.sll...hGYssuaspt.......st.chh......................ssstplpGlalsNToYsYsshppGspa.............................sth..........sshpc.s.saFplslhshD.......ssG..hhpshchhLADYR.ssp.......s..lssWpahDLsul..s..s.VpslcFshcuSDs..us.YG.hNTPAYhClDcl....	0	13	16	16
+14569	PF14718	SLT_L		Soluble lytic murein transglycosylase L domain	Eberhardt R	re3	CATH:1qsa_A_02	Domain	Soluble lytic murein transglycosylase (SLT) consists of three domains, an N-terminal U domain, an L domain (linker domain) and a C-terminal domain (C). The L domain may be involved in the interaction of the enzyme with peptidoglycan [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.33	0.72	-4.18	96	1072	2012-03-14 10:47:09	2012-03-14 10:47:09	1	2	1057	3	180	738	113	70.40	40	10.99	NEW	.pttlttpssltRlpELhthsc.........stA+pEWthLlsphs....p.p.p........pt..tLAtaAtcppWachuVpAoIpuKhWDpl	............................ss...tlspsPphARlcELhhhsh........cssARuEWspLlcstS....c.s.E........pttLA+YAasppWaDLoVpATIsuKhWDpL..........	0	31	85	137
+14570	PF14719	PID_2		Phosphotyrosine interaction domain (PTB/PID)	Coggill P	pcc	Jackhmmer:Q6ZT52	Domain	\N	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.44	0.71	-4.64	10	195	2012-10-04 00:02:25	2012-03-14 13:07:17	1	2	88	0	123	471	1	164.10	34	47.36	NEW	TYsVlYLGNVLTlhAK.GEGCl-KPLupIW+sYspp.+.sslpMKLsVosSGLKAsTcc.........+GLTEYWuHRITaCsAPscaPRVFCWlYRHEG++hKsELRCHAVLCpKpppAppluppLpppLpsALpEaKREKlp.....tQpA+Lshu.slhs..sPs.lP+RKLL..sGs..pNaRP.PVERSKSAPKLuSI-E-	...........................................apVhYLG..ps..sT.....ht.sp..G.cG.CT-csV.sc....l....W.....p+..p......p...u......+.....tss.....ph...c...Lplss...pGl..+h.p..p...h..-tt...............pps....h.c..t..Y..h..ltRIoYC.sA.D..tp.h.P+lFAWl..............YR.H........p.s....cc..............h....s..h........LcCHAVls.p+ttcActlAhhLhpshtpA..h..p.-.a.K..+.p+.........+ppt.......................................................................................................................................	0	38	48	82
+14571	PF14720	NiFe_hyd_SSU_C		NiFe/NiFeSe hydrogenase small subunit C-terminal	Eberhardt R	re3	CATH:1wui_S_02	Family	This domain is found at the C-terminus of hydrogenase small subunits including periplasmic [NiFeSe] hydrogenase small subunit, uptake hydrogenase small subunit and periplasmic [NiFe] hydrogenase small subunit. This C-terminal domain binds two of the three iron-sulfur clusters in this enzyme [1-3].	27.00	27.00	31.20	30.90	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.47	0.72	-3.95	163	2101	2012-03-15 09:29:21	2012-03-15 09:29:21	1	5	1192	65	410	1124	51	85.00	50	22.89	NEW	aupplH-s.C.RpsaF-tGtFscpaG-.ttt.GhCLaclGCKGPhTassCsphtWNt.ss..uaslpuGpPCIGCoEPsF.Dphssahpt	...........YGppIH-p.C.RRsHFDAGcFscpasD-utRpGaCLY+lGCKGPpTYssCSohcaNs..Gs..uaPlpuGHsClGCsEsGFhDctu.a...hh..................................	0	144	296	359
+14572	PF14721	AIF_C		Apoptosis-inducing factor, mitochondrion-associated, C-term	Coggill P	pcc	Jackhmmer:JCSG-Target_422903	Domain	This C-terminal domain appears to be a dimerisation domain of the mitochondrial apoptosis-inducing factor 1.  protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerisation and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.78	0.71	-3.91	23	200	2012-03-15 13:49:27	2012-03-15 13:49:27	1	9	126	9	116	198	7	98.30	44	20.11	NEW	AGENMTGAtKPYhHQSMFWSDLGP-lGYEAIGlVDSSLPTVGVFAKuospD.......sP.cusscsossslpscspspussssstsssps.sss.t.......tt....-DaGKGVlFYLRDcpVVGllLWNlFNRhslAR+llp-s	....................................................................AGENM.sG.A...t.......K..P..YhHQSMFW.SDL.GP-lGYE..AIGllDSS.L.sTVuVaAcsotpp.........p....tt..t...............................................tcpasKGVlFYL..+.sc..hVVGllLWN...lFs.+.hslARplltp.s......................	0	49	64	92
+14573	PF14722	KRAP_IP3R_bind	SSFA2_N;	Ki-ras-induced actin-interacting protein-IP3R-interacting domain	Eberhardt R	re3	Jackhmmer:P28290	Family	This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein) [1].  This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells [1]. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [2].	27.00	27.00	28.10	27.20	21.70	25.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.88	0.71	-4.66	8	175	2012-03-15 14:06:43	2012-03-15 14:06:43	1	4	68	0	90	165	0	137.00	44	18.07	NEW	.hhs+GpShNSou.SusousTsSSlSElL-hapEDsEElLasLGFGpDEPclso+IPuRFFsssSsA+GIsh+lFLcuQlpRIchEsPshuLsSRFRQlElLssVANAFSSLYSaVStpPsQKlussch.......E.hshssPlp+pS....p...cspusht+ltsp...s	..........................................hhphGpShsSst.st.pouussS.SlsElL-hhccDPE-ILhsLGFG.....p.....-.E.sDlsS+IPuRFhsssStA+GIDhclFLpAQh.pRh-hEsPs..LhuRF+QlphLshsssAF.sLhs.VSths.pt................hs....shphss......................s..............................	0	12	20	45
+14574	PF14723	SSFA2_C		Sperm-specific antigen 2 C-terminus	Eberhardt R	re3	Jackhmmer:P28290	Family	This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2 [1].	25.00	25.00	25.70	25.70	22.00	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.14	0.71	-4.54	5	106	2012-03-15 14:07:22	2012-03-15 14:07:22	1	3	38	0	47	107	0	157.40	49	15.79	NEW	HhsospTHSVPhsSGh.....uuSsHhoPAuCsaSs+HsPaPapspusssPssshst.......tplEMQLRRVLHDIRsThQNLuQ.s.h+G.Dhshs..hsT.p.SVpPLYEsThpELQshRRsLNlFRTQMMDLELAhhRQQoLVYpHMSEEERcEA-QLQTLRcAVRQELQELEhQLEDRLLuIcEQl	.....................................................................Hhtp..T+SVs..SGh.....ssosassPhtCshsp+H.tsasa.p.pssss..Pss...............lEhQLp+sL+slpso..........................oV.h.Lhp.sThpEhpsMRpsLshFRpQhh-LEhshhcQQshVY+HMoEEERhEs-QLQoLRpuVR.Elp-LEhQLp-RlhtlcEpl...........	0	3	7	16
+14575	PF14724	mit_SMPDase		Mitochondrial-associated sphingomyelin phosphodiesterase	Coggill P	pcc	Jackhmmer:Q9NXE4	Family	The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.	23.70	23.70	24.20	23.70	22.10	23.60	hmmbuild  -o /dev/null HMM SEED	765	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-13.23	0.70	-6.74	4	286	2012-03-15 16:48:53	2012-03-15 16:48:53	1	4	90	0	124	270	0	315.60	27	82.32	NEW	QPSFLLAoLKADslsKPFhQpCQDLV+VIEDFPAKELHsIFPWLVESlFGSLDGsIVGWNLRsLQuRhNPsEYslsh-FLDPSGPMMKLVYKLQAE-YKYDFPVSaLPGPVKASIQEpVLP-CPLYHNKlQFPsSGGluLNLALNPFEYYMFaFAhSLITQKNhPluhHlSouDSAYFILVDpYLKaFLPTEGSVPPP.SossGGolPSPsPRoPulPFsSYGhHHTSLLKRHISHQsSVNADPAuQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPphKLElLHYRLSlSShhh.sPhps.u.tuLHuYQEsFpPTEEHVLVVRLLVKHLHAFSNSLKPEQlSPSAHSHTsSPLEEhKRVVVPRFVQQKLYlFLQHCFGHWPLDASFRAVLEMWLSYlQPWRYssEKssPso.-.psRsVsEKWusFVQENLLMYTKLFlGFLNRsLRTDLVsPKNALMVFRVAKVFAQPNLuEMI.KGEQLFLEPEhVIPHRQHRLFhoPshGGSFLSuW.PslTDsSFKVKSHVYSLEGQDCQYpQMFGsEsRsLVL+LAQlIsQA+QTAKSISDpSAEosAspSFhSWFGhuSsDhNGSYsGsDLDEhGtDol+KTDEaLEKAL-YLCQIFRLNtuQLsQhhhslGouQD-sGKKQLPDCIpuEcGLILTsLGRYQlINGLRRF-IEYQGDPELQPIRSYENAhLVRhLaRLSSslNcRFAspMsALCSRcDFLGphCRaHLTsPthsp+t+hSPltpcps.ucstuPRlSLR	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	44	55	91
+14576	PF14725	DUF4466		Domain of unknown function (DUF4466)	Coggill P	pcc	Jackhmmer-JCSG:target_419245-SP18803A	Family	\N	25.00	25.00	394.90	394.70	21.50	19.70	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.00	0.70	-5.14	6	11	2012-03-16 11:55:18	2012-03-16 11:55:18	1	1	11	2	3	13	0	315.10	48	94.39	NEW	ACcDp.....-scSsL+NDhIK+Tl..uPslsGpcIEFAYAMu..sppG+lssApscASIAGAsGThF-hpSaYT............uoGpDVPVQsscDusTsGssoTsshhccss..................AATLRYaYllPc-A+GKsVSFoFSApSSsGpplSYphssY+ISKMDMK+slslpNtsACYlSltD....MpsYTKt-VssN.sLAsKIDhlYlYp.plsshDasHAhVoPuosscYls.ushlPuGhsNs.TthcKphsV+DtQLpshph.uVYIDDlDFcplDhusAsDYslsL+p-sGAaVcTADGKYtAYVYlNplssSuKphTVSlKRYsL	.....uCp-......-scssL+NDhIK+Th..GPslVGppIEFAYAMu..spcG+lssApsEASIAGAsGThh-ppSaYT............uoG.DVslQsussolTsGssoTsshhccss..................AATLRYYYllPEEA+GKsVSFoFSApSSsGppVSYphssYcISKMDMK+slslpsuuuCYlSIAD....MpsYocs-lssN...usKIDhVYlYp.plsshsFsHAlVoPuusspYls.uVpLPuGlsps.TtlcKthsV+DtQLtthph.uVYIDDlDFpplDhssAssYAlNL+p-sGAaVcTADGKYtAYVYlNslssouKphTlSlKRYsL	0	3	3	3
+14577	PF14726	RTTN_N		Rotatin, an armadillo repeat protein, centriole functioning 	Coggill P	pcc	Pfma-B_645 (release 26.0)	Family	Rotatin and its homologues such as Ana3 in Drosophila are found to be essential for centriole function [1]. A deficiency of rotatin in mice leads to randomised heart tube looping, defects in embryonic turning [2], and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homologue - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localises to centrioles and basal bodies and appears to be essential for cilia function [3]. This family represents the N-terminal domain.	25.00	25.00	26.30	26.30	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.23	0.72	-3.42	25	85	2012-03-16 13:05:11	2012-03-16 13:05:11	1	3	68	0	57	75	0	97.60	43	5.77	NEW	tEIRhRALcsIpsKlp+sLlphp-ls.ppp.LL+pLlc..WFsassss.tp-cVLsLlpc.LhcpshuspllpclGs.cF...Lscl+....phlssph.ptplppllcsL	.......EIR.RAL+sIlsKl-HsLlshsDLl.pc+hLhlpLLE..WFNFsslP.hp-EVLsLLpc.LlKaPsAsphLh-lGAl-F...LocLR....ssl-Ppl.pscIDslLDsL........	0	17	21	35
+14578	PF14727	PHTB1_N		PTHB1 N-terminus	Eberhardt R	re3	Jackhmmer:Q3SYG4	Family	This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis [1].	25.00	25.00	27.50	27.00	23.40	21.20	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.26	0.70	-5.52	25	181	2012-03-16 15:04:53	2012-03-16 15:04:53	1	9	114	0	104	189	5	348.90	39	50.44	NEW	MSLFKsR-WWoopssp.sEcaDp.usLsVuNlDNssstp.......DpIlVG..SasGhLRlYpP.........ppssacsp.DLLLEppLppPILQlphG+F.........luus.pslpLAVLHP++LslYsl.....pshsGp..sppust.......hpLpLhYEHpL......p+sAhNhshGsFGGscs...........+DhlCVQShDGtLpFFEQ-shuF.s+hLss.aLLPGPlsYss+sDSFVTsooshpl-sY+.........YpsLAsuspsppppt...p...........................su++lsssWohslGEpsl-Ip.................lsphsp....spssIlVLGE+oLFslccsG.pl+a.K+L.-asPsshhsYss..hscsshp........................lllsocospLhlYpDssLtWuAph...spsPVAlpsusht.............sl.pGhlVsLspsGpLpssYLGT-P...........shhhsPshp..s+-hsY-chpcEhpcLpclI+pussspch.......psccclplpsplsspl-	.........................MSLFps+-WWss..hs..tEpa....c....t...u..sLhlushsspts.t..p......................DpIlVG..Sh.Gh.LRIapP..........ptpshpsp.clLLEsplp.tPlLQltsG+F..........lssp.p....pLAV.Lps+plslYsl..............tth.Gt....hthusp.............................hphplhaEHpL......p+sAhshshGsFGssps...........+chlClQShDGhLhhaEQ-shs...............F.sphLPs..hLLPGPlsYss+oDoFlTsoSshplpsY+..Yps.Luhussttt..................................ss+plss-WohslGEpslDlp.................lsphsp................stsslhlLGERshasLc-.s.G.pl+ah++L.-hsPsChh..s...Yss...hppsshp........................hlluscsshLhlYpDssLtWuspl...sthPV.Alplushp.....................................sl.cGhIVoLussGpLpsuYLGT-P...........sha.p.ss.lp..s+..pl.sYpphphEhpcLpchI+chptstsh.......pttcpltlph.l...........................................................	0	45	55	82
+14579	PF14728	PHTB1_C		PTHB1 C-terminus	Eberhardt R	re3	Jackhmmer:Q3SYG4	Family	This family includes the C-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis [1].	25.00	25.00	33.70	25.20	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.16	0.70	-5.67	6	158	2012-03-16 15:10:26	2012-03-16 15:10:26	1	7	107	0	92	177	5	312.30	34	42.03	NEW	solKlsl+s+hphppspLolssptP..LslopDshhFcslus.tho+shshslYl..psshhPssLpsplVsSYsosp.....GlPRllQppspLPL+LhhcPsQPsKsAsHKLTlssNpsPVs......LhsLFPEFhp..EcusssAlGFQhlu....Gp+..VTlLAuKoSpRYRlQSDpFEsLsLlscchlhRh............ccpas+pshhDtF..plohuGshPlpphh-hIDsHF-lRhshccLcspLpptusQaRsIQRRLls+FK-KoPsPLpsL-hLL-uTYsplhtluDplcEhccsLh+utscLsuuspLllLlltLhhsL.ssctlplLEushsPllhDhpE.uWEEhsDAuloaLL+TsLuKSSK-Quhs..........hpsshc.PpDsS........+L+KHlshlsDRls	.............................................h.hp.t...hptspltl.st.P..l.hspsp.h..sh..p.hss..t.spp...hthshah....ptth....Psphcsphss.oasp.sp...........G.....hP+llQpphpLPLpLls..hssp.PsKsA...sa...KlTlc.TNp.s.sls................LhslF..........s.t.Fst............pc....s...ps...ssh......Ghphls.................Gsp......lTlLASKsSp..R.YRIQS.-phEsLaLlspELlhRl...........................................pph..hpc.t...hs..h....thsh.s.....ssh...P.........lpcaachlDpHac.lRhphcchpchLscpAhQFRu.lQ+RLLs+a+-+sPssL..p..tL-sLL-sTY..cplhths-thpp.ptphhpthstLpssspLh..h..hllth...p.h.p.pththlpshh.s...p.............p........uWEE.stsulshLlphs..pp.pttt..................s...t...sht........ph++phshhh-+h.....................................................	0	35	45	71
+14580	PF14729	DUF4467		Domain of unknown function with cystatin-like fold (DUF4467) 	Godzik A	adam	JCSG target SP18127A; Pfam-B_491 (release 26.0)	Family	Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan	21.90	21.90	23.90	30.30	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.19	0.72	-3.66	24	517	2012-10-03 02:27:24	2012-03-18 08:21:19	1	1	217	2	13	123	0	94.00	44	78.01	NEW	YsccIDclhKhppcppcch.tp.s.scsppc.a-+ccuNhYVY-cGKhIllu.Yp.hK.sscpl.hYhhYchps..cKhph.ccch.....s..s+pYhccH.cPDY+EpN	..YpK-IDcshKlQspppcph.uKhs.schhschc+cDuNhaVYccGKlIllu.Yp.hp.sc-ch.aYaAY-hpD..cKsph.pp-h.....D..sc+YhppH.cADYc-EN..	0	3	3	11
+14581	PF14730	DUF4468		Domain of unknown function (DUF4468) with TBP-like fold	Godzik A	adam	Jackhammer: JCSG target SP13279C	Domain	A large family of (predicted) secreted proteins with unknown functions from human gut and oral cavity.\	Typically forms a N-terminal domain with FMN binding  domain at the C-terminus. Experimentaly determined 3D structure of this domain shows a variant of a TATA box binding - like fold, but no detectable  sequence similarity to other proteins with this fold	22.60	22.60	24.50	24.10	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.89	0.72	-4.29	50	160	2012-03-18 18:57:27	2012-03-18 18:57:27	1	3	125	0	29	156	6	92.60	26	32.94	NEW	aopplpssuh..op.splYsphhpWhsphhps...h.sSplshssccpGhIsupu..pthllFs.....s.shLS.....ls+sphpYpltlcscDs+hclohoclp.YpYp	.........Fscphpls.uh..Sp.spIYcphhpWhspphpp..........t.sS+lshsscpcGsIsupG..cchl.lFs.....s.sslu.....LD+splpYplplsCc-s+splphscIp.YpY............	0	13	24	29
+14582	PF14731	Staphopain_pro		Staphopain proregion	Eberhardt R	re3	CATH:1x9y_A_0	Domain	This domain is the proregion of the cysteine protease staphopain. Like many papain type peptidases, staphopain is synthesised as an inactive precursor and cleavage of the proregion is required for activation. This proregion has a half-barrel or barrel-sandwich hybrid fold. The proregion blocks the active site cleft of the mature enzyme on one side of the nucleophilic cysteine [1]	27.00	27.00	47.30	46.60	23.30	22.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.13	0.71	-4.49	6	356	2012-03-19 09:54:49	2012-03-19 09:54:49	1	2	195	4	4	96	0	167.80	64	43.35	NEW	KpscVNVcsKcVPpcV+cLApcQYLSaVsuLDKtSNpcsuuYTLGEsFKIYKFNpcSDGNYYYPVLNK-GcllYlVTISPKssss.KtSppsusYSINVSPFlSKsLNQYKsQ..pITILTspKGYahhsEDsKl+LVLKTPhsssKppKpsscpsss+.hpphKQTuolTK	...KplplNVcscpVPpcV+sLAQppahuYspuLDK..N..t.cpupYpLGEsFKIYKFNtcpDssYYaPVl..p-GpIsYhlTlSPKsp...ppSpps.pYolplSsFluKsLsQhKDp..pIT...lLT.spKGaY.hppstKs+LVhtTPh.pshK.Kcotphsoup.hppLKppsosTh.........	0	2	2	4
+14583	PF14732	UAE_UbL		Ubiquitin/SUMO-activating enzyme ubiquitin-like domain	Eberhardt R	re3	CATH:1y8q_D_03	Domain	This is the C-terminal domain of ubiquitin-activating enzyme and SUMO-activating enzyme 2. It is structurally similar to ubiquitin. This domain is involved in E1-SUMO-thioester transfer to the SUMO E2 conjugating protein [1].	27.40	27.40	27.50	28.00	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.67	0.72	-3.88	74	271	2012-03-19 13:18:53	2012-03-19 13:18:53	1	9	228	6	191	271	5	89.30	29	14.34	NEW	pltlsspchTlpcLl-clL+ppLuhspP-lhl...ssslla-s--..........t.hssshpKpLu-l............GlpssohLslpDhpQc......hplplhlpcpcphcp	................lplssc+sTlpsLh-cll.....KpcLuhst.......P-lplp....spuslLhss--..........t.h-sN.pKpLu-h............Glp..sGo..hLpscDh.p-......hsl.l.lhcpcp...t.................................................	0	58	97	153
+14584	PF14733	ACDC		AP2-coincident C-terminal	Woodcroft B, Eberhardt R	re3	Woodcroft B	Family	This family is found at the C-terminus of apicomplexan proteins containing the AP2 domain (Pfam:PF00847).	25.00	25.00	25.10	25.30	24.00	22.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.84	0.72	-3.86	28	106	2012-03-22 12:53:11	2012-03-22 12:53:11	1	4	11	0	100	116	0	94.70	22	6.97	NEW	sssptLpltKpAlphlLpDLppsClspl...tthts.............................hpphlptHlphlpsu.tshpplhsYlplFssplppshLPSshshptQthllpuL	.............................................................................................t.tphlpltKtAlhhlLpDLpppshsph.....hh.s...................................................................hp.hpphlctHhphlpsu.pshppltsYlplFspsIppppLPSphshptphhllpuL.....	0	37	47	88
+14585	PF14734	DUF4469		Domain of unknown function (DUF4469) with IG-like fold	Godzik A	adam	Jackhammer:JCSG target GS13689A	Domain	A C-terminal domain in a large family of (predicted) secreted proteins with uknown functions from human gut bacteroides	22.60	22.60	22.60	23.10	22.30	21.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.24	0.72	-4.15	29	126	2012-03-23 06:08:24	2012-03-23 06:08:24	1	2	44	0	33	111	1	97.60	31	43.92	NEW	IspVsDssTGptssslTsGtshplpGsplKls.Gs-......susGlhhss.........ppG........s.htlssshlstNpPSpLhhhlPstLssGp.YpLplsTpauu.usphLKssRospa	......................tlpD.sTttts..GslTsGtshhlpGpplKls.Gs-......s.ssGlhhss.........ppu........s.stlshs.lshNsPSclhhhlPssLscGp.YpLplsTQaus.ssphLKsPRoh.................	0	15	30	33
+14586	PF14735	HAUS4		HAUS augmin-like complex subunit 4	Eberhardt R	re3	Jackhmmer:Q9H6D7	Family	This family includes HAUS augmin-like complex subunit 4. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].	25.00	25.00	25.90	25.20	23.80	22.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.44	0.70	-5.06	12	109	2012-03-23 08:46:42	2012-03-23 08:46:42	1	3	76	0	61	109	0	209.10	34	62.65	NEW	stphsspsshsss.stlLGlsttpLhphhssp.sh.....thptpL.pElEppL+cKC.sLlsaapPsspssucshptsKss+Lsphlctcp..cphpptctphpcshhhhc+phppYhpsLhpsLplLppllp-a+LcpQs-hDchpppaLpsKC-sMhhKl+s.phplLpDTYTtEolsAh+pIRchLpsAhcptcp-hppupptLpsYEslG.cF-slscEYsclhpcl-s+pWsLpclpps	......................................................................................h.p.....tss.tt..s.hLGlp.t.Lhph....p....sh......hptpL..ElEtpL+pKC.....sLhshas.ss.......pssup..th.ptspsh+LsEhlhtth..pphpctcs.....t.pEph.hhh-+p.upY.pVL.ppLslLpp...Ll...p-p+LcpQ......schDchptpaLph+CpsM.hKL.Rh.Ehc......lLp-.TYT.sEpltsh.+h.IR...cpLptuhc.tppphpcupph.LpsYc.sls.c.........F-p..........ls+pYpplhpthEshp.Wslpphph..............	0	16	30	44
+14587	PF14736	N_Asn_amidohyd	N_Asn_aminohyd;	Protein N-terminal asparagine amidohydrolase	Eberhardt R	re3	Jackhmmer:Q96AB6	Family	This family of enzymes catalyse the deamindation of N-terminal asparagines in peptides and proteins to aspartic acid [1-2].	24.00	24.00	24.00	24.10	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.78	0.70	-5.53	19	160	2012-03-23 10:23:26	2012-03-23 10:23:26	1	4	114	0	93	169	0	232.10	37	83.22	NEW	thtSpsspsVsstslLYVpQREaAsT...sPpDpsVsllGSDDATTChlVVlRHTGSGsssLAHhDGos.Tcsulshhlstlpshs.s...tpGRLElHLVGGFpD.................scphScpLshpILpuFc+pp--IHLpTsClsEhNshlc.sGlphPllYGIuVNlKTGclFPAoF..ss+GPDctLRpARhh.......ssuphlslYDsppphl+IGPhpasPhhs..sshWLppsDchILppLSTSPtsEPPHFVppl+uslpFlh-HPps.sslFPcspP+ha+Rsc.sGpWc+l	...........................................t...p.sss.thLYVtQREhAss......sP.t.s....tpl.sl......lGoD-ATTChlVVlR...csusG......s...ssLsHhD..........uss.scttls.hhpplpshs........puRlEl..HLlGGFsD.......................s.cthSppL..s...hpllptFccpp.....c.....lc....Lho.hCVs..-hNsh..............c....st.......phPllaGluVsl+Tucla..AoF......s+GP-c.LRtARhh...........sst.hlsl.YDspht.l+IuP..hsapPh.t....ssha...LppsDp.lLpphSTSP.sEPPHFltphRtslhal...cp..s..thF.s.ppshhac+sp.sGh..W...........................................	0	32	46	69
+14588	PF14737	DUF4470		Domain of unknown function (DUF4470)	Coggill P	pcc	Jackhmmer:Q8N9W5	Family	This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, Pfam:PF01753, at their very C-terminus. Others are also associated with DUF1279, Pfam:PF06916.	25.00	25.00	27.80	26.10	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.40	0.72	-4.27	100	314	2012-03-23 14:25:58	2012-03-23 14:25:58	1	21	155	0	250	334	1	98.50	23	12.55	NEW	haGsos...Ahsl...hpp....................tt..s.ppslslLhh..GsG.DhRpllpTlsshs.pp.p............p...lplhlsDts....tllARNlllLpl.....lhs.s......ppssphhhc.laasshls	.....................................................................hG.osAhslhp.........................................s.ppslslLlh.............G..sG.DhRplltTlspt..tp.tt...........................plphhlh-hs.pllA.RslllLpl......hhc.s...................pptsphhhclahshhh...................................	0	118	170	216
+14589	PF14738	PaaSYMP		Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1	Coggill P	pcc	Jackhmmer:Q7Z4T9	Family	PAT1 (proton amino acid transporter 1), also known as TRAMD3 of AAT-1, is the molecular correlate of the intestinal imino acid carrier. It is a proton-amino acid co-transporter having a stoichiometry of 1:1. Due to its mechanism, PAT1 activity increases at acidic pH, which correlates well with the acidic micro-climate close to the brush-border in the intestine. Glycine, proline, and alanine are the preferred substrates of the transporter. The maximum velocity is similar for the three substrates. All substrates are transported with low affinity, showing Km values in the range of 2-10 mM. The transporter does not discriminate between L- and D-isoforms of these amino acids; in addition, beta-alanine is transported with similar affinity as alpha-alanine. Similar to the IMINO transporter, the amino acid analog MeAIB is recognized by PAT1. The transporter is strongly expressed in the small intestine, colon, kidney, and brain.	21.60	21.60	26.40	21.60	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.97	0.71	-4.49	32	172	2012-03-23 16:23:11	2012-03-23 16:23:11	1	10	109	0	105	175	2	146.70	38	20.68	NEW	usQT.YRES-AQTsPYoP..-.aslp.s.ss...sP..ElLsLssLpasc.G.L.PuGhtEVEhIERARc+RsaEssLP.s..........hs....Dts..ph...p......pR...+phh-t.hEhcEWthREp-IpchQchRL-llpchlpcREcppcphsppRl-phtpphppc+pttlp+lctctl..cthR+	.............t.sQT.YR-u-sQTsPYpP..Ehhspp.ss...hs..............ElloLusLpa...........uc..G.......L...PsG.tEVEhIERARcKRAaEssLPs..........hsDts....ph...p.......cR+chhpthEhcEWt.REp-Ipc..lQchRL-llpchLccREcpppphstpRl.ptthpphpcp+ctpltplphphhpshR+..........................	1	44	53	77
+14590	PF14739	DUF4472		Domain of unknown function (DUF4472)	Coggill P	pcc	Pfam-B_085261	Family	This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, Pfam:PF00225.	22.70	22.70	23.40	28.70	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.25	0.72	-3.59	12	44	2012-03-23 16:37:54	2012-03-23 16:37:54	1	2	35	0	29	51	3	107.70	38	21.45	NEW	SEEp+LpISKELVDLQIcsp+l+EQaEAEhFELKNc..................lLpLEsRlLELELct-.....phststsshtcphphspp.p+chttphh.h+pph.s.spsh.p.pscpccLu.pL.	.SEEp+LQISKELVDLQIpTp+LpEQaEAEhFELKsc..................lLpLEsRVLELELcs-.....pss..spss.tctht....spc....+pchtsphh.hcpph.s.scsh.s..tcppcLu.tL.h...............................	0	10	13	18
+14591	PF14740	DUF4471		Domain of unknown function (DUF4471)	Coggill P	pcc	Jackhmmer:Q8N9W5	Domain	This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, Pfam:PF01753, at their very C-terminus. Others are also associated with DUF1279, Pfam:PF06916. This domain is more C-terminal in many members to DUF4470, Pfam:PF14737.	25.00	25.00	26.40	26.20	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.83	0.70	-5.18	18	137	2012-03-23 16:41:55	2012-03-23 16:41:55	1	9	98	0	86	142	4	253.10	29	55.42	NEW	hlslptLKaKERDtLEthFpaWpst...ppsaclschW-...pRlRphLGsRYDpRsGlaDWDhsMpL+-.ptup.IssQEYRpWRcsGlAFsa.......sE.t.-aspPNKThssuhl...psGpsahpRGYlGDIpTGPFhuFG...lcss-.....E+h.h+ohcG.....pscapuTDloE+Nlhplh........aELp.....sp...........ssap.hsts...........-....................sps.p..th..psptsh....sp.p.....hhsstpVpl+Fl.slph.lchhpp.+p+apphFDllFlups.hspaLpss....hhp.sh..+ss.AllllETt+alssh+K-phppatscl+clh+pushcsstshs	...................................lslptLKa+ERDtL-thhphWt........t........ps...........ashsphWD...pRlRphhupRYDtRpsh...hDWDhp..MpL+c..pt........uphIp.pcaphWRpsGlAFph..........................h-t.tYp.hPN+Thsshhh............pp.............GpphhtRGYhGDIhsuPahuFG....lcspc.....pph.hph.ps.....p..hsut-lspcNlh.phh........hpltst..................ttht.hs.t..........p........................................................................................................tp.t..t......tt.t.........t.......h......thplpal.sh.s..hpp.l................p.+.ppa......pthFphhahuss.hsphlpsp..........htt.hh.......tst..uhlhhEht.pahhshpp-phtta.ppltchsptsGht......s.......................................................	0	38	48	71
+14592	PF14741	GH114_assoc		N-terminal glycosyl-hydrolase-114-associated domain	Naumoff D, Coggill P	pcc	[1]	Domain	This short domain is also a very small family found at the N-terminus of GH114, glycosyl-hydrolases.	22.00	20.50	22.90	38.90	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.67	0.71	-4.42	9	17	2012-03-23 18:28:37	2012-03-23 18:28:37	1	5	7	0	16	17	0	124.80	26	28.58	NEW	shssp-lssopDshspYlchus.........GuphphpFshPu.husssstsLslsssht.s.ttSutcWph-hash...ssssWsplGD.utAsShsWosssLsls.ssst.cFV.ussplplphs...psssspushlDh	.......hsstshssotDs.sp.lchus.........uuphphhFshPu.sus....sphhololsspht.ssttsuscWph-hasa....sussWsplGD.otssohsWosh.sLsls.ssP.....s.sFl.ssstlphphp...psusspu.hlD...........	0	13	14	15
+14593	PF14742	GDE_N_bis		N-terminal domain of (some) glycogen debranching enzymes	Godzik a	adam	Jackhammer:YP_001865398	Domain	This domain is found on the N-terminal of some glycogen debranching  enzymes and is usually followed by the GDE_C (PF06202) and in this  sense it is analogous (but probably not homologous) to the GDE_N  (PF12439). Its exact function is unknown	22.10	22.10	22.80	41.80	21.10	22.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.12	0.71	-4.93	158	381	2012-03-25 04:19:21	2012-03-25 05:19:21	1	3	312	0	197	416	23	191.80	27	27.41	NEW	sL+cussF.hls-ppGDI.......s..ssspGLahpDTRaLSchpLplsGppshh...L.uusspps.ttshh..tlss..........l.t.s...st..hscsslplpRpRhl.t...su..hhEclslpNasspssphplplphsADFsDlFEVR..Gtp.ct..c+Gphh...sp..h.ps.s...p....................lthpYpG.D.....shpR.poplph.....t.........s.sssp...lss............sp....hsaplpLsPppphpltlpl	.......................L+pussFhlsDtpGDl.......tsssspGLahpDTRhLSphpLplsG.....ptP.h...L.uusspps.t.tuhh.pLss..........l...t.s...st..hscsslplcRpRhlt................ss..hhEclslpNasspssplplslphsADFsDlFEVR..Gsp.ct....c+Gpht...sp..spss...t.........................l.php.YpG.D.....shpRssplph.......p...........stPsp..lss..................................sp....ssaplplssptphslhlp..........................................................	0	54	119	159
+14594	PF14743	DNA_ligase_OB_2		DNA ligase OB-like domain	Eberhardt R	re3	CATH:1fvi_A_02	Domain	This domain has an OB-like fold, but does not appear to be related to Pfam:PF03120. It is found at the C-terminus of the ATP dependent DNA ligase domain Pfam:PF01068 [1-3].	25.00	25.00	25.00	25.10	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.01	0.72	-4.30	136	673	2012-03-26 11:48:33	2012-03-26 12:48:33	1	11	649	7	120	539	455	66.90	42	21.06	NEW	.G+GKapGhhGALhl..............ch.ss.....G..hcFclG.....oGFoDpp...RpsPP...........lGohlTY+YpGhT.psG.....hPRFssFlRlR	...............GcG+apGthGAlls..............ch..ts.....G......hpFpIG..SGasDp-...RcsPP.......................hIGollT..Y+YpGlT.p.pG.........hPRFssFlRlR..................	0	40	76	108
+14595	PF14744	WASH-7_mid		WASH complex subunit 7	Coggill P	pcc	Jackhmmer:Q2M389	Family	This family is the central, conserved region of proteins that form subunit 7 of the WASH complex [1]. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes [2].	25.00	25.00	32.10	31.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.96	0.70	-5.60	29	153	2012-03-26 12:33:06	2012-03-26 13:33:06	1	10	116	0	104	160	4	310.00	48	31.51	NEW	FLYWpR.slh.Phahpplacsshpsp..+l.ahhsAhpDshshltt.........spHhps..stslhcs.....apct.lhpplcccllcPLCpclEs-LRLpsHu.cL...phs.spsPhps....s....hp..Dlsp...hl.plsPl+hhsphlsl+pclE+YLspTFYNLsslAhHDWKTYtEMRsLApp+YGLphh-s+LPsQTL-QG.LDVLcIMRNIcsFVu+YsYNLNpQlFlEc..sS..s...uKHLsTIsI+HIANSIRTHGsGIMNTTVNasYQFLpKKFhlFSQFLaD-aIKSRLlK-hRaa+cp.+cp...hs..tpYPa-RA-cFt+pI+KLGl.......sss...GpoYLDpFRhLITpIGNAlGYVRMlRSGGlchsucuhpFlP.slpsh.ssap	................................................aLaapR.shhPhahpplappshpst..pl...YhhsAhpDshs.hhp..........upHhps....p.Llps.....appp.lhphlpcpllc.LCp-IEpDLRL.psHo.HL....pls.sp...sPh.cs.................u..h+..Dlsh....ah..plpPl+.hhscalcl+.shVp+YL-psFYNLoTlAlHD..WtTYpE.MRs.LApp+YGLths-sHLPsQoL-.........QG.LDVLpIMRNIHlFVupYhYNLNsQlFlE+..sS...........s........sKHLsTIsIRHIANSIRTHGTGIMNTTVNF.sYQFLppKFhlFSQFhaD..-+IKSRLlK-hRaa+Eh.K..cp....................ts....ppYPa-RA-+Ft+sIRKLGl.........................os-...GpoaLDpFRpL......IopIG.NAhGYlRMlRSGGL+ssusuhpFlP.chcs............................	0	37	50	80
+14596	PF14745	WASH-7_N		WASH complex subunit 7, N-terminal	Coggill P	pcc	Jackhmmer:Q2M389	Family	This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex [1]. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes [2].	25.00	25.00	32.80	27.90	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	567	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.86	0.70	-6.33	14	161	2012-03-26 12:44:04	2012-03-26 13:44:04	1	8	111	0	105	164	3	456.10	29	49.95	NEW	GpFhp-asppLpplccsl..s.so..lsps.....hshth-PlsLphhsh......EphslhcL.l.......co-.pKlhNKllsslAuLCsph+pLpccAc.pah.sLlhaGEt.hs..........-st.s........tcs.hphuphlshhpcL.talpRshsllpslhpQluAlhs......h.hshspVHh.sVa-sls-LLshLlolDElhptposlsspWsLY++hl+olppssupa..s.ls.c.cLptL-+hLtcl-spLLsGsIFpphlpphhD...t.hsVscNsths.pEhst.l+plhsplEu+...s-.pp.h...pppcphltlsuLhVlhapLatp.....hD+KLhKplh-lt++hstlslssNllWhPssFLhp+hssh.h..Kthscts.p.shp..+pphLpphstsht+pspphthQlutWhlcMposhsps.....h.hctLpspspLllpGlhhAtplSpllcsllNLHsuLstPhoKosVhslC+llEhLKsIptTFappphhlschlspllQalshhhhphLpssK++lst....DppYocc+LDlLSuLpLupcsLpGssTp-RlhllpLuLushhph..csl+s.......-chcplp.lhp+Lctlu-lppplptts...DsS	.....................................................................................................................................................ssltl.hhs...................cp.s.l.pl..l........................ppc..splhsKllsshusLstEhptLp.pApp........phh.s..Lhh.aG-t....hp......................................................-st....p.......tcs.hphu+hlshLpcl.talpRshp...Vlh...sllpQLuula.s.....t................t..h..........t.hp...t..........l+hp.shac..plucLLthllslDEllppp.slpstaphY+.+h.lpplppssspa.........s.ht..pccl.c.hcphlhpl.....c..tpllss.lhp.tslpp.a-....................h............lpp...sphhspchtt.lcphhspl-sph...spspp.h................pp+pphlslsuLhslh.hplahs..............................h-p+hh........Kplhchp.p+.hPhltlh..uplhahPstFlhpph..Ps...h...+.h..h.s.ppt.t....sht................pp...t...hhppt.stp.h....p.....phpphhh.lssWh.hc..Mpohhstp................th.tp..l....pptsplhl..p.GhhhA.plpphltshh......sL.....ahs....hp...tPhopssVpsls+hlphLKslppha..hp+th.hl..spshshlhQplph.h.p.ltsh....+pplht........ppp.sp.pp......h.-.....hL...uulhls.phl.p..us...o..hp+hhhlpLslshh.hp.....p......hhpt.....................pch..h..hhtplphlsp.htt.h....s...................................................................................	0	40	49	81
+14597	PF14746	WASH-7_C		WASH complex subunit 7, C-terminal	Coggill P	pcc	Jackhmmer:Q2M389	Family	This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex [1]. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes [2]. The C-terminus is predicted to include a transmembrane region.	25.00	25.00	50.50	25.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.87	0.71	-4.66	22	137	2012-03-26 13:08:12	2012-03-26 14:08:12	1	9	112	\N	97	142	2	166.40	44	15.89	NEW	ThpAucpLDsllpsLtc.sao-Go-YF+hLlssFu.phRs...s+NtHL+NFYlIlPsLTlNaV-ahlpsK-KlhKKsKs....susF.TDDGFAhGlAYILKLLcQhppFDSLHWFpolcp+app-ppplp..............pp.ttp.psp...........tD.....-+h.pshp....LTh++lpshpcEasLLhhohoSARIFFc	....................................................ThpAu+pLDsVlushsc.s.uE.Go-YFKhLV-.....VFuschRs.............s+NhHL+NFYlIVPPLTlNaVEaplssKEKLtK....KNKh....uusF..TDDGFAhGlAYILKLLDQappFDSLHWFpSV+p+YtpEhcslt................cp.pspssp.....................pD.....-chhpThp....LTt++Lcsh.p.EapLLhhoLoSARIFFc................................................	0	36	48	74
+14598	PF14747	DUF4473		Domain of unknown function (DUF4473)	Coggill P	pcc	Pfam-B_8489 (release 26.0)	Family	This short family is largely confined to Caenorhabditis proteins. The function is not known. There are two well-conserved aspartate residues.	25.90	25.90	27.20	26.70	25.10	22.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.60	0.72	-3.76	42	147	2012-03-26 13:48:54	2012-03-26 14:48:54	1	3	5	0	145	125	0	80.40	28	75.08	NEW	ushs.s.....s--h+uELhuAGlSppussGlhplspcatsph.hh...pssccsscphhpchps-scsalco.StpD.QpsYpsalc.c+	................s....t-ch+AELhuAGlSpsuscGlhplupcapsphsts...psspcuucphhsphps-scsalKo.oppD.QstYpsalc.Khp.................	0	21	42	145
+14599	PF14748	P5CR_dimer		Pyrroline-5-carboxylate reductase dimerisation	Eberhardt R	re3	CATH:2ahr_A_02	Domain	Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (Pfam:PF03807) and a C-terminal dimerisation domain. This is the dimerisation domain [1].	25.00	25.00	25.60	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.17	0.72	-4.04	862	5462	2012-03-26 14:57:42	2012-03-26 15:57:42	1	17	4352	40	1427	4011	1723	105.90	36	39.32	NEW	hsEp.hDulTAlSGSGPAYlahhlEAhscuulp..hGLscchAtpLutQTlhGuAph...lh.............................p.....................pPu......pL+cp.VoSP...GGTThsulpsL..Ecs..u.lcsslhcAlpA..AspRupEL	...............................................sEphhcslTuloGSuP............AYl..a.hhlEAh.s-..A.uVp..hG.ls............+.ppAhclssQsl..hG.uAphlh...........po.sp.......................cPu.........pL+-p.VsS.P...GGTThtulpsL..Epp...u.hcsslhcAlpu..uhp+upch......................	0	448	860	1182
+14600	PF14749	Acyl-CoA_ox_N		Acyl-coenzyme A oxidase N-terminal	Eberhardt R	re3	CATH:2ddh_A_01	Domain	Acyl-coenzyme A oxidase consists of three domains. An N-terminal alpha-helical domain, a beta sheet domain (Pfam:PF02770) and a C-terminal catalytic domain (Pfam:PF01756). This entry represents the N-terminal alpha-helical domain [1].	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.53	0.71	-3.83	150	617	2012-10-02 12:47:07	2012-03-27 09:42:00	1	15	250	8	432	619	22	114.30	24	17.60	NEW	sscclsthltGuccp...hcc++....clpphlt...p-P...apc..pshhahoRpEpacpulcKutthhphhpp.hth............s.p-.................hhhh....tshhspstPhs..LHhsM..FlP....slpsQuosEQpccWLshApphcIl	...................................................................scphsthltGutpp...hchpc....cl..phlt...p-P...hpp..tsh..h..ho+p-phctulcKstphhphhp.p.hth...........s.p-...............................................hhhh....hshhst..shshs....lHhuM..Fls....slpsQGTsEQhpcWl.hu.phpIh.....................	0	160	230	355
+14601	PF14750	INTS2		Integrator complex subunit 2	Eberhardt R	re3	Jackhmmer:Q9H0H0	Family	This family of proteins are subunits of the integrator complex involved in snRNA transcription and processing [1].	25.00	25.00	36.40	27.30	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	1049	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.73	0.70	-13.76	0.70	-7.04	13	186	2012-03-27 12:41:57	2012-03-27 13:41:57	1	7	101	0	136	185	1	667.70	34	87.28	NEW	lspLuphscpEIRPlLPCLVRMSLhSPLDpopchs-sRKplLplLsGlElVNSI.VuLLSlDFHtLEsDlKKEQQlRpKlGhtpp-SlhhpuLps.ulsLEFERS-ssR+lRlVLSELLtlhuQlp-..........pss-..hh+sS.....-LFDs-lYLEEluDllCIAlAELPuLLsIp-lsEsLL+lcNGsplIChlVANhPDsFcEVCpuLIsNG-p.DE-sssG+hRhssLptLspMNPoQALthRupsVEhC+MPuLAltLoL-ps......p.........uDLVAFlSGLLLGsDpplRoWFAhFIRsuQKR+s-....ALphLRccLLcplpslhsp......................uh..putLs-ppVVpuuuLLRLYCALRGIAGlKFs--EsssLlQLlTS+PPPosAGlRFVoLGLCMLlACPSLI.....uspEhEppslcWlpWLl+EEAYFEssSG.........soASFGEMLLLhAIHFHSNQLSuIs-LVCSTLGMKlslRPsoloRhKplFTQEIFTEQ...VVsuHAV+VPVTssLsAslsGFLPlHCIaQLLKSRAFuKH+VPIKsWIY+QICsSVoPLHPlLPuLlEV..YVNSlls..Pss+s..p..........ppsNcPlSEpEIppVFps.....................s..pp..ph.pp................................pssLTsQLLlLYYLLLYEDsRLsNhpshlsts+p...hKsYSscFhScLPIKYLlppAp+cQpcYuuLFSPLLRLLATHaPHLslVDDWLc-Etlssp...ps.....thpss..tssloppslscAFsplpspPsp.sh+llcpLhphsspsLhPaAphllpahphlLscslPRhlpc.hhpplWhRLNoVhPRpLWVhTlNA..Lhspt......p..sLTp-slslDPLpVLRCDcRVFRCsPlhsIlLRlLpuhLAASRopLupHlp-p....Phsp.....hupts.s-s-REEL+hALlAAQESAAVQILLEsCLcTc-D+s................................pssphhtLREl+ullCSaLHQhFIADPsLAKLVHFQGYPpELLPloVpGIPSMHICLDFIPELLuQs...cl-KQlFAIsLsSHLulQYuLPKSLslu+LslNsLsTLLuVLsospRhpLFpslLPuLVRhscAFPPLs-DslslLhQlGRlstSQuuL	..............................................................................................................................................................................................................................................................................................................................................................................................................................hh..............................................................h.h........h...h.h............................................................h...t.lh..t....................t......p..............hlh.l.ph....s...h..h.h.....p.ht.s.h.hh.lthph..................hl.hhpshlh........................................h..........................................................................................................................................hh.hhssh.....hp............hht.........p.............th..h.hshlhs.....h..h..........................pt........hhphh.pt................................shtphhlhhthhhhstphttl..hhpthlt..hc......................t.h..ht.hh.h..pthh.p.....ls..s..ph.sss..t...hs....s.t........................hshh.....sl.tL.....ptp.a...pht..h..ht.hh...ph...t....Php...h..llp...hht..h.................................................................................................................................................................................................................hhhhhahh....ht..h...t...........................................................a.....th.....hshp.hh...hpt......th...lh..hh...hh...hs...........h.....................................................................................p.................................hh.................h............h.......ha..h..h...............................................hs.......P....h..t....h..p....hh.hhl.hl.........p..................h..t.........................................................p.lt.shh..p.s.hhphLl-hh.................................................................thpt.hs..lHphals............lh+llhaQ...................ths.t.l...st.lPuhh.h...l.ph.......p....hhsl..hhs.l...pa..l.pshths.p..hh................phh..hh..t..h............................h.h....hh.sh..h...a..h.....................h.................................................................................................	0	65	79	112
+14602	PF14751	DUF4474		Domain of unknown function (DUF4474)	Godzik A	adam	Jackhmmer:JCSG target SP18061A	Domain	Domain found on N-termina of few families of uncharacterized  Clostridia proteins. Typically followed by a proline-rich domain  or other kinds of repeats	21.10	21.10	25.70	24.10	17.30	16.20	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.65	0.70	-5.19	12	51	2012-04-03 19:57:09	2012-04-03 20:57:09	1	9	45	0	8	47	1	222.40	33	41.00	NEW	LNphhc.sGauY-hppDlFYSthcAWQRchGYs+LYDEAAshhsMlhDCEPlaFsYsGKpWLIEhWKGQYGlsTGuElGVYpss+..ls.s.ha+sTFYcslpDc-hlslShsLh+ssKslaph.pshHWWLTGFpLGpFSpPppLhh-hoITh.DppMppAFlcuLhch.G.Yp.pcEhhlpsNoVplpascP+osQPhs+sphs-shlQhpN+h.CpLYphh..T+sasps..hD+lthlpthhP-la	.........lst.ht.hGas.Y-..ppDlFaSp..h-sWQ....RchGYscLYDcAusshuMlhDs-PlhFsYssKcWhIphWKGQY.s......l..sTGuElGlYpssc.s..l.......s...hhpssaYpsh......pD.s-hh..hohsLcK.s..G.+.......s...l.a...p...............p.......pstHWWLTGFp.....hG.c.F..Spsp-LshshsIsht.c.t...MhpAFlcuLhph.G.Yp.pp-h.h.tppV.hhhs.spp..t..hhps.h.cthlQhhNp..CthYp.h..Tt.h.ph...-+l.hl...hP.ha.......................................................	0	4	8	8
+14603	PF14752	RBP_receptor		Retinol binding protein receptor	Eberhardt R	re3	Jackhmmer:Q9BX79	Family	Proteins in this family function as retinol binding protein receptors [1].	25.00	25.00	26.70	25.20	20.90	22.50	hmmbuild  -o /dev/null HMM SEED	617	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.21	0.70	-13.14	0.70	-6.20	10	202	2012-04-10 09:35:04	2012-04-10 10:35:04	1	7	52	0	108	188	1	404.80	30	72.30	NEW	sssC..csoVs.sLaptChAslSllllLlLuhLsRRcphpsc.....sh+GRhGLlsPlDFLustssRhshuAsFGAlhsslshL.LhoEshhPht....sPoh......s+uhh....hlluhl.hushYYPlhAChost.a.hlutlLGhhhShsahsVpVaQplpCP..........pusplh+YhoLls.lPhLLCLuFLslpashllV+Sl+s.+tG...susp.....slp.sSa.ccYl+s...LLp+p.Lpp.t...tsc.phhSWhpsh.p.pIYsP-PsF+FPh+hlhoslLohluLYphALl.lsullsTlcclRsslsssls.aLLsuhsllhSp......sppclltpVKcaLaulEssalsollLusLlolshLh+sLVsaRppLKtLaRGsph.Lsspa+oPpPoppulsshMpaSuaQsAFlhhGhLIQpllFFLsslslsahlVlPllHGcsLhLL+uLs.hh.shalslllsllLQslhAphhFLps......+ptshsLsNRRuhashoYFLFhhNVLlGlhsulWRlLlSuLhsshhluRlDhSlLppshEohDPGYpoYhGhL+lEsupSHPVhluFCpLLLpupp..pcs..t....psol+.s..cpuhQhlpp.ccspupGuss.uuRuRsRWhLhYTLLpNPsLlshRKst	..........................................................................h.......................................................th..Phshht.........h..hhhhhhh.sthh.h....s.t...sh..................................h....hhhh.hh.h...s.h..hhPhhhChs.....hu.hhG..hsh.hh.h.hh.h....C..........................t....h....h......h..h..hhsh....hhl.h.a.h.............h....t.......t.....................................................h.t.....h........................................................................F.hs.phh.s.....hh....hh.hh...h...............................................................................................s.....hh.shh.s..h.h.h.hp.hh...ha.Rtph.thhtGt...h.....t.t....shhshhtasuaphA..hhhh..Ghhl.phh....lhh.hhhhh................l...h.hPhh.t....p..h.....hh.p....l...h....hh........hhhhhhh...lQ.hhuthhFlp........tt..tlsNR...+sha.h...sahlF.hNVllGhhssh..RllhoslhshhhluphDholh..thtsh.D.Ga.sahshLhh-h.popPshhsFCtlLlpstt.....t.................................h................................h.+W.lh.tLhpN..l.....................................................	0	55	60	74
+14604	PF14753	DUF4475		Domain of unknown function (DUF4475)	Eberhardt R	re3	Jackhmmer:A4D161	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.	25.00	25.00	25.20	25.00	20.90	24.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.80	0.71	-4.80	11	195	2012-04-10 10:52:20	2012-04-10 11:52:20	1	2	81	0	110	177	3	126.00	34	61.63	NEW	Yp+IVG-.DDGG+LFo.cEYEcYKKpVhPhRlKNRlasSWpsssGhDCKlIGPEThCFCsHR.aKpHcTDhpp.lspcRPhtlPC+sstCpC+saaYlPhpGSpslRCp.CKHhss-Hss..hsa+Cs+ss....pCsG.FcSsaoCuCGpss.cHpTllE....T+-ERhupGKPVup.D.......VPYtuMG.GlTGFSSLs-Gh.R....lDsSGhGsss	.................................................................................................................stohCFCsHh.h+pHph.........p.....tlsCp.ttCtC..a.alP....................s..h+C+.C+H.hppHss.....shh.Cp.t.ss....tCss.FpSsah.C.s.Csp.h.tH.T.hhE....Tcp..h.t.t.....................................................t...........................	0	42	49	67
+14605	PF14754	IFR3_antag	PPRSV-IRF3_ant;	Papain-like auto-proteinase	Coggill P	pcc	Pfam-B_8065 (release 26.0)	Domain	The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase Pfam:PF05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.	25.00	25.00	573.10	572.10	19.50	18.40	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.71	0.70	-5.38	2	79	2012-04-10 11:02:07	2012-04-10 12:02:07	1	4	2	0	0	81	0	249.00	97	12.89	NEW	MATFSATGFGGSFVRDWSLDLPsACEHGAGLCCEVDGSsLCAECFRGCEGVEQCPGLFMGLLKLASPsPVGHKFLIGWYRAAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTsVYAusWlsSPAANSLlVTlDQEQDGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGlNAsSGGLKFHIMRuSPQRAWHITTRSCKLKSYYVCDISEA	MATFSATGFGGSFVRDWSLDLPAACEHGAGLCCEVDGSTLCAECFRGCEGVEQCPGLFMGLLKLASPVPVGHKFLIGWYRAAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFhSTDHASAKRFPGARFALTPVYAssWVsSPAANSLIVTlDQEQDGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGsLKFHIMRSSPQRAWHITTRSCKLKSYYVCDISEA	0	0	0	0
+14606	PF14755	ER-remodelling		Intracellular membrane remodeller 	Coggill P	pcc	Pfam-B_2813 (release 26.0)	Domain	This domain represents subunit nsp3 of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, and is a tetraspanning transmembrane protein that contains a cluster of four highly conserved cysteine residues. These are predicted to reside in the first luminal domain of the protein. Arterivirus nsp3 proteins are uniformly predicted to contain four transmembrane helices, with the N and C termini of the protein residing in the cytoplasm. NSP3 are localised to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.03	0.71	-4.13	5	141	2012-04-10 13:33:59	2012-04-10 14:33:59	1	8	7	0	2	101	1	140.80	66	10.05	NEW	GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRsRPSAoSS.GDVKDPAsVPPVPKPRTKLAKPSPTQAPTPAPRTRhQuA.....SsQEPPsGsusAPASAPKWRVAKTVYSSAERlRTELVQRARSlGDVLVQALPLKTPAVQRY	..................................GPPPAPVSASVLDHILEAATFGNVRVVsTEEQQRPVPAPRsR+SsoPP.GD.V.KDsAsVP.PVPKPRTKLAKPSPsQAPTPAPRTpPQsA.....Pp.EPssuTAAAPuSAP+WRVAKTVYSSAERhRTELlHRApSlGDoLVQALPLKAPAVQRY............................................	0	0	1	1
+14607	PF14756	Pdase_C33_assoc		Peptidase_C33-associated domain	Coggill P	pcc	Pfam-B_535 (release 26.0)	Domain	The nsps or non-structural protein subunits of the arteriviral polyproteins such as porcine arterivirus PRRSV and equine arterivirus EAV are auto-cleaved into functional units. the function of this particular domain is not known.	25.00	25.00	27.10	25.60	21.90	18.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.16	0.71	-4.48	4	550	2012-04-10 15:06:29	2012-04-10 16:06:29	1	10	6	0	0	558	0	108.70	91	8.18	NEW	sSPDAVEVSGFDPACLDRLAtVMHLPSSsIPAALAEhSGDssRPsSPsTTVWTVSQFaARHpGG-HPDQVCLGKIISLCQVIE-CCCSQNKTNRsTPEEVAsKIDQYLpGAsSLEECLA+LE+ARPPSshDTSFDWsVVLPGVEAAs	...SPDAVEloGFDPACLDRLAcVMHLPSSsIPAALAEhSsDss.RssSPssTsWTVSQFaARHtGGsH.DQVpLGKIISLCQVIE-CCCpQNKTNRsTPEEVAAKID.YLRGATsLEECLAKLERVSPPSAADTSFDWNVVLPGVEAAN.	0	0	0	0
+14608	PF14757	NSP2-B_epitope		Immunogenic region of nsp2 protein of arterivirus polyprotein	Coggill P	pcc	Pfam-B_58 (release 26.0)	Domain	This domain is in a non-essential part of the nsp2 (non-structural protein) subunit section of the arterivirus polyprotein. This domain carries seven small sequence-regions that are predicted to be potential B-cell epitopes.	25.00	25.00	42.60	27.50	20.90	24.90	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.77	0.70	-4.92	22	1615	2012-04-10 16:54:06	2012-04-10 17:54:06	1	14	11	0	0	1542	0	119.20	49	22.05	NEW	VKsYPRWTPPPPPPRVQPR+TKsVKSLPEsKPVPAPRRKVRSDCGSPlLMGDNVPsuhEDLsVGGPLshPTPSEPhTPhSEPsLsPu.Q+ls+PsTPLStsAPVPAPRRTVSRPhTPLSEPIFVSAPRHKFQQVEcAN.AusTLTpQDEPLDLSASSQTEYEAsPLAP.QNhGlLEsGGQEAEEVLSEISDlLNDhNPAPVSSSSSLSSV+ITRPKYSAQAIIDSGGPCSGHLQ+EKEACLSIMREACDAoKLuDPATQEWLSRMWDRVDML	................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+14609	PF14758	NSP2_assoc		Non-essential region of nsp2 of arterivirus polyprotein 	Coggill P	pcc	Pfam-B_6704 (release 26.0) 	Domain	This non-essential region of the nsp2 subunit of the arterivirus polyprotein of such as porcine arterivirus PRRSV and equine arterivirus EAV may offer immunogneic surfaces to B-cells. It is associated with Peptidase_C33, Pfam:PF05412.	25.00	25.00	29.10	145.00	21.80	19.00	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.45	0.71	-4.19	18	61	2012-04-10 17:03:01	2012-04-10 18:03:01	1	4	4	0	0	61	0	167.70	66	15.20	NEW	KtFEtsAsEEVQEuGHKAVHSALLAEGPNsEQVQVVAGEQLcLGGCGLAlGsAp.................SssDSMKENMhNShEDEPLDLSpPAPAuTTTLV+EQTPDNPGSDAGALPVTVRcFVPTGPhLRHVEHCGTESGDSSSPLDLSsAQTLDQPLNLSLAAWPVKATASDPGWVHGRREPVFVKPRcAFSDGDSsLQF	................................EEVQESGaKsVHSA.hAcGPNcEQVQVVsGEQLKLGGCsLsVGNA+tss.sSuu.h...................shtsEPLDLSpPAsAATTT..tEpTP-NPGsDAGALPVTsRcFVssGshL+HVEHCGTESGDuSSPLDLSDAQs.DQPLsLSLssWPV+sTASDPGWVhGtpEsVFlKPRtshSDG-SshQh	0	0	0	0
+14610	PF14759	Reductase_C		Reductase C-terminal	Eberhardt R	re3	CATH:2gqw_A_03	Domain	This domain occurs at the C-terminus of various reductase enzymes, including putidaredoxin reductase, ferredoxin reductase, 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component, benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit, rhodocoxin reductase, biphenyl dioxygenase system ferredoxin--NAD(+) reductase component, rubredoxin-NAD(+) reductase and toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component. In putidaredoxin reductase this domain is involved in dimerisation [1]. In the FAD-containing NADH-ferredoxin reductase (BphA4) it is responsible for interaction with the Rieske-type [2Fe-2S] ferredoxin (BphA3) [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.77	0.72	-3.69	153	1813	2012-04-11 08:06:00	2012-04-11 09:06:00	1	26	1065	20	581	1646	395	82.00	28	19.73	NEW	WFWSDQa-h+LQhAGl......ssutDp...sVlRGs.ss.t...t..sFol.a.....ah.+supLlAlculNp....sp-ahhu++Llsput.ssssstLA...DsussLKsll	..........aFWSDQYs.hplQhsGh.......s..p..u.h..Dc......h.l.lRGs..ss...p..........p.....phhs.a........ah..psu.....pllussulNp.......s.c.p.h....t.hs.+.chltsut..sh..s..s...t...lh.c.t..L.................................	0	153	355	470
+14611	PF14760	Rnk_N		Rnk N-terminus	Eberhardt R	re3	CATH:2pn0_A_01	Domain	This domain occurs at the N-terminus of Rnk, an RNA polymerase-interacting protein of the GreA/GreB family (Pfam:PF01272). It has a coiled coil structure [1].	23.00	23.00	23.00	23.10	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.40	0.72	-7.89	0.72	-3.88	110	932	2012-04-11 13:03:29	2012-04-11 14:03:29	1	4	909	6	162	424	20	41.70	54	29.57	NEW	pPsIhlophDhcRL-pLl-.....shstps.sstptLpsEL-RAclV	....+PoIIIs-LDsERl-tLLE......psAhushPlA-ALsAELDRAph....	0	32	73	117
+14612	PF14761	HPS3_N		Hermansky-Pudlak syndrome 3	Coggill P	pcc	Jackhmmer:Q969F9	Domain	This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072 [1].	25.00	25.00	26.30	25.30	23.80	24.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.64	0.70	-4.94	10	92	2012-04-11 15:52:16	2012-04-11 16:52:16	1	4	66	0	50	89	0	187.50	42	18.61	NEW	RlhssHsFsSQcVssscp.EPsthCsu...GtDtLFlu..suuCpVEVasls.pppspshssFuTlupVlplsYScsGDYlVTIEcKspso.............alRsYlNWcsp..pscsstVslRhsGhphpssps-ss.pcQhEllElPL.scsPhCIuCCsloGsLLVGssspLllF.pLKspsl....scchphlDF-cpLI.hhsuasPscluhCssYIAlho-LEVhllKLsp	................plhshHsFtuQpls.sp...EPt.hCsu...G.-tLFl...suuCc..VEsaslt...pEhsp.+ssFuTl.GcVl.plsYo-u.GDYLlslEcKspso............................FlRsYsN.WRpt...................psppshVsl..Rhh.....G....hpsshspsh...cpphpllEhPL.scsPhsluCCsspGsLLVusps+llLapLphphh.........spchuhlDFE.pplhhhh.shsPhcluhCssalAlho-hElllhKLp.s................	0	11	15	30
+14613	PF14762	HPS3_Mid		Hermansky-Pudlak syndrome 3, middle region	Coggill P	pcc	Jackhmmer:Q969F9	Domain	This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072 [1].	25.00	25.00	34.40	34.00	17.70	24.20	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.10	0.70	-5.86	9	100	2012-04-11 16:43:41	2012-04-11 17:43:41	1	6	68	0	54	97	0	358.40	41	36.33	NEW	ptpPhElLG.csp.ssls...lslc.oTslss-hppthpV.............ppLLaRRFsPchpshhhs-ph..+LHSLQLhPhYpps...................thtss.ppsspppcLhulhCFFShPppGYLYslspu......ssLlS...sYtYspcsppsVLsspFLHsITpsuLpsaTlRsSssss.cpsshlDshhcsCPshohcVChltlp.FIGLpslsphcsallLLops-spph.ph.......................ttsuWsLYhl.sssohhQLYp-hl-huppYcsspspohhHLLuEAHLLlRsAL..hchs.tcsscKpEL..............hpAapESCuhLGDhaSR.-.spchcLALPYY+MSGLphs-llpR..h.ht........shppuh.sRGhIaaLpHuL......hcchsEpLScphAspVlphFthu-PcpL	................................................................................t..Ehlup.sppsuhs...lhlE.sTuhts-tht.hpl.............ppLLa+RFs.PDhsph.s..s.--h......+LHSLQ..LhPIYQpu...........................................thpsctps.o.p..c+chlul..FCFFShPcsGYLY.lsps.......VcLhS...sYpYs-+spQAVLospFLHVITS.........ssLQsaTVRCSAssA+cc...DsY..hDTT...hKuCPPVSh-VCsLRlQlFIGL+slCph+sHllLLTKAss.Esh.cRpps.hphhph......................................t.tssp.t.sssspsuWsLYll.sshsshpLYc-hl-YupoY.+os..po..po..hhHLLuEAHLLlRuAL......h-ssphc...s....s.c+t...EL............................................................hcAF+-SCu+LGDpa....SR.........hs..ppp..cL..AlPYYKMSuLshs-V....lsR.hthshp...........st.pph....tcGLlaYlp+sL.........hcphspp...L...scphu..s..cllpha.ht-Ppp..............................	0	16	19	34
+14614	PF14763	HPS3_C		Hermansky-Pudlak syndrome 3, C-terminal	Coggill P	pcc	Jackhmmer:Q969F9	Domain	This domain is downstream of the mid domain family, Pfam:PF14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072 [1].	25.00	25.00	27.90	27.50	22.30	20.70	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.17	0.70	-5.46	4	71	2012-04-12 10:25:22	2012-04-12 11:25:22	1	4	47	0	35	70	0	308.80	58	33.88	NEW	MKNlsPLpAlpYLRKL-s..hsSVLVTLTKAsMALKMGDLDMa+NEMpSHSEMhLlCGFlhEPRLLhpp+cGpllPTEhAlaLK-sQPGLLVASlluLpcNsKIslEEAD.FFKsLCsK..DEDsVPQLLVDFWEAhLVAC.P-sVLpELhFKLTSQYVWRlSK+phP-ThPL+TsEDLINoCSHaGLI.PWVshlMSs-ShhsKshsEDl.KLQSllsGPShDltshLPaLEsLu-ssNsGLolH.lLChTRLtpYEcsIDpLLc+hPEAVl.YApHELKE-spslWWpKLLPELCpRl+pstschplalSSLKETLSVVAsEL-LRDFLNlLPEDGTAAFFLPYLLaCS+KK.Ls	.............MKNlsPLsAhpYLcKL-ssGhsSlLlTLTKAAhALKMGDLcha+sEMcpHuEMpLVhGFILEPRLLlQQ....+KG....QllPTELAhaLK-TQPGLLVASlLGLQKNsKIulEEADuFFKV....L.CuK..DEDslPQ......LLVDFWEApLVAslP-lVLQELhFKLsSQYlWRLSc.........+....ps....P.DT....hPLRTuEDLINuCSHYGLlhPWVplLhSs-ShsDKsasEDL.K.LQSLlCGPShDlASIlPFLEPLS.ED.ThA..G.LSlH.lLCpTRLpEYEpsIDpLL-RCPEAVIsYANHELKE-.scsLWWK..KLLPELCpRl.+...s.....G...GE+.p...LaL...SuLKE..TLSllAsEL-L+DFlNlLPEDGTAAFFLPYLLaCSpKK.l.................	0	5	7	18
+14615	PF14764	SPG48		AP-5 complex subunit, vesicle trafficking	Coggill P	pcc	Jackhmmer:O43299	Family	This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments [2]. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs [1].	25.00	25.00	26.50	25.30	21.30	22.00	hmmbuild  -o /dev/null HMM SEED	460	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.59	0.70	-6.00	14	140	2012-04-12 10:55:25	2012-04-12 11:55:25	1	4	79	0	89	136	0	309.70	30	54.76	NEW	-LQcACLlEuVtlLchlC+p....DsS..hlhRshPpl+pLasRls......ussu.......pu....psLLsIhQFFLsHGEs.sshDu-ushcphFspl.ucpFpcPhLAa-hlpFhhpNp.plLssp.sslhpp.FPsLLK...........hLAWsu.sLhscFVtlLPsLlsssTAlElLHslLDLPCLoAAL-hphRuus......su..tpslhs.p........................scssush-uhpsPhtcsLFpalLRsEuu..ssh.-R...Lss.LHplLtshussP...RVhQCupslPsLLclaFsslhcpAsssLlspLl.lLLERsstLa.lpsapt-V++VLSptlLtLsph+PsLlV-Lp+-lL-FlG.ospsh.pu+p-hasallWAlGEYhSsuhD+RCos-hhspaFEsLEs.lLaElopop.............ssushspsssRllssLMTsLsKLAoRsp-LlP.RV...uLhLoKhpo...psh.t.s.s-ps..sttlhpRAs-LlsLLKhPuVAthVLs..Posss	............................................hhpsl.hh..hsp.....ssp..hlh+shshhptlhtRh.......ss.s........s....hhlLslhpFaLsa.u-h..shhDs-s.ht.hhtt..h.s..a.s.hhs.thhthh..p....h........h...hP.lh+...........hlA.ps..h.t.h..lhP..hhsstohh.hh..lhDLPhlshsh...........................................................................................................s.ts.......hpsha..lL+scss...s.htp.........s.h.thht.h.t.s...............RhhtshphsP.lLphaFsssh.p.s...st................sLhs.tLh.hlhtR.s.ha....aphp.......lpphh.p.hh.hhphpPthlh...tp.l.t....t........tt.hh.plsWhlGEa.us..........t.h.thaEsLEh.hhac..................................................................phhh.lhsshsKlAsh..-h.s.+s....l..........................................................s.....................................	0	26	52	67
+14616	PF14765	PS-DH		Polyketide synthase dehydratase	Coggill P	pcc	Pfam-B_852 (release 26.0)	Domain	This is the dehydratase domain of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products [2].	27.00	27.00	27.10	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.91	0.70	-5.26	177	5569	2012-10-02 20:54:35	2012-04-12 14:52:00	1	1171	1046	21	2255	5792	232	275.10	19	12.09	NEW	HPLL.G.tplths..sssphhapspLs.hps.PaLsDHtl.tGpsllPGsualEhAhpAuppht.....tt........shtlc..-lslppsll.ls.pss....shplplslpss.stst..............phplhSpsssst...............WshHspGplt.......................sh..h..tpt..s.s...ls...stthYpph...t.phG.ltY.GPsFps.lc.plhp.............s..p.shApltls....pshtttt.........ahL.HPulLDuslp.sh..................tt.ttshLPh.ulsplplh........t.....t.hhscsch.....tsts......htsclplhD.ssGpslsplcuLph+tlsstshts	...............................................................................................H.ll....t....s.....t.tth...h..hp.s.p.l.s..hp...p..h..s..a...L.........s.D.H.t...........l.....t...........G...........p............s...........l..hPu...sual-...hAl.p....Au..p..pht..............................................................shplc....-lsh.t.p.sLh...ls.......t............s..........s........s...............hplp..l....s.....lpss...tttt............................p.h..plhopss..sst...........................................hshHupGtlt...htttt................................h......s.................h....t......t.........h...............................t............t....................s......................................ls........................ssp...h...Y..pth............t...phG...h....p.Y..Gs....s..F...pu..lp..phhtt.........................ss..p..shAclt..ls....................psht.t.t.tt....................................ahl...HP...u..........lL......D.ushp..sh....hhhh...............................ttsts..tshlP......h....uh.pplplh..................................ssth.hsh.sph...............................stts....................h.t.s.s...l.p.l..........h.......D....t........s......G.......p........s...l...h...plpulthp.ht.....t........................................................................................................................	0	518	1299	1894
+14617	PF14766	RPA_interact_N		Replication protein A interacting N-terminal	Eberhardt R	re3	Jackhmmer:Q86UA6	Family	This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta [1-2].	24.00	24.00	25.30	24.50	23.60	22.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.87	0.72	-4.49	25	123	2012-04-12 14:36:35	2012-04-12 15:36:35	1	4	80	0	63	129	0	41.10	45	19.07	NEW	ss++s.hKt.psPsWK-plRccChcRlRcpRscLLp+hRtss	.............+RshaKh...soP....sWKEsaRpcCl-RhRssRs+LLs+aRps....	0	20	32	47
+14618	PF14767	RPA_interact_M		Replication protein A interacting middle	Eberhardt R	re3	Jackhmmer:Q86UA6	Family	This family of proteins represents the middle domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA [1-2].	25.00	25.00	25.80	26.00	24.10	23.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.86	0.72	-3.23	27	109	2012-04-12 14:37:26	2012-04-12 15:37:26	1	3	65	0	48	112	0	74.40	36	36.46	NEW	p.hlp-lhp-EhppLppsspsh..................hh..psh.phh......pEh--.Lt.h-.....-lppEhhpp.EhphhtphEpthphE-phLsthlp	............h..lVQEVMEEEWpsLpssps.............................hscshst....pEh.-.LusLE.....EIpQELlpp..Etsl...lp.EaE.cshph--phLs.hl........	0	8	18	31
+14619	PF14768	RPA_interact_C		Replication protein A interacting C-terminal	Eberhardt R	re3	Jackhmmer:Q86UA6	Family	This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger [1-2].	25.00	25.00	25.70	25.70	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.40	0.72	-3.58	50	138	2012-04-12 14:38:09	2012-04-12 15:38:09	1	4	109	0	85	130	0	80.90	31	35.91	NEW	lCPVCppspLpt...spph...lhC.......sC.G.lplspp.............thshc.pLpshLppslspHtpp..C..spsPpFslp..ssss.t....sLhhpCpsCcahpll	......lCPVCpptsLph......sssh......lhC........pC.G.Lplssp................................ttplohp.pLctpLppslscHttp..C..spsPpFslp...........sssp.p....sLhhpCtsCchhsll...................	0	27	41	66
+14620	PF14769	CLAMP		Flagellar C1a complex subunit C1a-32	Coggill P	pcc	Jackhmmer:Q6P047, Pfam-B_2704 (release26.0)	Family	This family represents one small subunit, C1a-32, of the C1a projection (the seventh projection of flagellar) [1]. Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules in flagellar plays a distinct role in regulating eukaryotic ciliary/flagellar motility. The C1a projection is a complex of proteins including PF6, C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin. C1a projection is involved in modulating flagellar beat frequency and this is mediated via the C1a-34, C1a-32, and C1a-18 sub-complex by modulating the activity of both the inner and outer dynein arms [2].	22.70	22.70	22.70	22.80	22.20	20.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.32	0.72	-3.86	50	207	2012-04-12 14:49:21	2012-04-12 15:49:21	1	5	87	0	139	195	0	94.30	27	33.37	NEW	hpslhFspp.psaohppsSshhs..lhpplhp..sht...pthshtcshpha+pll.hppulp.+Pshs...htlFohppl+tlh..-ahhpo...aaRHY+LYpasFosphphshpt	......................................................pshhasht.psFoh.phothhs..lhpplhp.sh.........t..t.thslp-shphhppll.hpausp....cs.hs..............htlFshcpltslh..DYhhpo......aa+HaKLYcalFssppchpl..s.........................	0	59	70	89
+14621	PF14770	TMEM18		Transmembrane protein 18	Coggill P	pcc	Jackhmmer:Q96B42	Family	The function of this family is not known, however it is predicted to be a three-pass membrane protein.	26.90	26.90	28.90	28.50	26.00	24.80	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.61	0.71	-4.58	43	161	2012-04-12 16:07:47	2012-04-12 17:07:47	1	4	128	0	104	149	2	117.70	37	69.08	NEW	cshhsFhpulDWp.EPWlluLlsFH.llhllsslhoR+phsh..QhslFhlhlshVahuEplNchuupp...W..+pFupp..pYFDspGlFlSlVaSsPLLl.shllllshlhphsplhlclKptpL+c+t+p	...................s..h.shhhslDWp.EPWLhuLhsFH.llhllhslhoppphsh..Qlh.lFlhhlhhVYhuEhlNchuAtN.W.....+.FSpp..pYF...DspG.hFISlVaSsPLLlsshll............llphlhphsp...lMsclKptpl+c+t+.h...............	0	37	58	81
+14622	PF14771	DUF4476		Domain of unknown function (DUF4476)	Coggill P	pcc	Jackhmmer:Q86XN7	Family	\N	22.50	22.50	22.70	22.80	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.08	0.72	-3.95	42	221	2012-04-12 16:46:32	2012-04-12 17:46:32	1	12	125	0	88	194	12	93.60	26	26.52	NEW	tspshsshphpplhphlpph.sF-s-+lphlphhtts....p....hosspssp.llphasFsss.+lchLchlhspIhDh...p.stptlhssFs....Fs.ss+p+spcll	.........................h...hhs..phcphhphl+hh.sas-sphchlcshhpp.....hs...hosspssp.llshaoFsc-.+lpslclltspIlDt...p.Nhp.l.chhp....hs.SpKc+h+chl.......................	0	51	59	71
+14623	PF14772	NYD-SP28		Sperm tail	Coggill P	pcc	Jackhmmer:Q96MC2	Family	NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation [1].	22.10	22.10	22.10	22.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.16	0.72	-3.94	28	241	2012-04-13 08:02:08	2012-04-13 09:02:08	1	6	113	0	152	239	2	101.00	27	17.72	NEW	+VusDtREtpRRhcEppt+pphpp+LcpEstpshpchppIst+WsplhphphPp-LpcplppQ+ptCpcllppK-plIs-hpp-LcppD-cYlpsl+cQucDl-	.......................t.thcE.pR.Rtc.pp..h.pp.hhcK....Lp.pEtcp.optphscI....spcWcphhcp..tpspELpcplpt.ppphpcllcpKcplIp..........p.L.pp........-Lcpt--pYspsl+pphcslp.......................	0	60	76	113
+14624	PF14773	VIGSSK		Helicase-associated putative binding domain, C-terminal	Coggill P	pcc	Jackhmmer:A4D997, Pfam-B_8865 (release 26.0)	Family	The function of this short, serine-rich C-terminal region is not known. However, as it is frequently found at the very C-terminus of P-loop containing nucleoside triphosphate hydrolases, it might possibly be a binding domain.	19.30	19.30	20.10	19.50	19.00	17.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-8.99	0.72	-4.06	20	116	2012-04-13 08:13:48	2012-04-13 09:13:48	1	6	103	0	91	108	0	58.80	41	6.30	NEW	SQLAAhlp..........tpsptttppppsstsKpDPIQAIL.AuAGVEYTHENSEVIGoSKlEEpLSRRAE	...................................h.................ptths.t.+pDslpuIL...usuGVpYTHpNsEVIGSSKlEppLSRpAt......	0	15	36	60
+14625	PF14774	FAM177		FAM177 family	Eberhardt R	re3	Jackhmmer:Q8N128	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 205 amino acids in length.	25.00	25.00	25.10	25.40	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.45	0.71	-4.20	23	150	2012-04-13 08:18:13	2012-04-13 09:18:13	1	4	89	0	91	148	2	107.10	36	57.19	NEW	tssshppsE.......pcctps..hpsP+RllaFuDG.sMEEhSo-EE..-cp-..ttppsh.hss.lDsscLshGPalhapsh+lusssluuCDalGtplAohhGITss.KYQYtl-EY.Rhpcccpccpp-schs	...............................sp.......-.....t..t...hphP+RlI+FssG.sMEEYSo-E-...pt.p....pps..hss..lDs..scL...sWGPalhahhh+huosolusCDaLGE+lAshhGIosP.KYQYsl-EYhRhppccpccppcpp.......................	0	27	40	66
+14626	PF14775	NYD-SP28_assoc		Sperm tail C-terminal domain	Coggill P	pcc	Jackhmmer:Q96MC2	Domain	NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation [1]. This short region is found at the very C-terminus of family members of family NYD-SP28, Pfam:PF14772.	27.00	27.00	27.60	27.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.85	0.72	-4.27	38	177	2012-04-13 09:00:41	2012-04-13 10:00:41	1	6	106	0	122	167	5	57.70	34	9.39	NEW	caWpphupllspcphclWcsLpcuLp+YhclLpcRtpllp-s...ppLcpQNsEL+sLLpQYl	...........taWpths.pshstpp.clWcsLtpuLp+Yp..p..lLppRspLlpEs...psLcpQNpELcpLLpQYl....	0	56	73	100
+14627	PF14776	UNC-79		Cation-channel complex subunit UNC-79	Coggill P	pcc	Jackhmmer:Q9P2D8	Family	This family is a component of a cation-channel complex.	27.00	27.00	32.60	31.50	26.70	22.00	hmmbuild  -o /dev/null HMM SEED	525	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.82	0.70	-6.12	7	116	2012-04-13 09:36:58	2012-04-13 10:36:58	1	3	72	0	67	108	0	431.60	53	21.57	NEW	.p.DssRhuhYPNL-YpsLYsALs.LlDVsPLIQhG.psFGpAlLQCLuCLLPFL-+DlIDsLPYLsASoluVLPspLHp-IlNhLCaYILPFTI..TRpp-.ppEshssQSVouVIMhVhQYosNPuHHCQLLECLMsLKpsVhKDlLsVIAYGTusuRuSAAKLLFYYWPsFsPNlaDRKslhsKhs.shsPFsCQR-tCPNAGNAEAsKVCYDHsISIsausDoPPPLYLCIECANcIHREHss.hFhDILHPMQplShlCENKNCRSp-KpAlSICFSoECASaNGNHPIRYCpQCHsNRHNsRRGuD.....HlsHpuLssshphDuEhQsahVEulVSLL+EAc.hs.psp+-spp.pt.....................tsssssssDshohEERQLLGRYGlWLLVGhCTPs-sTPsElLGRLLuMLFHWFHsTAY.aD..sQs..ESolEKLKs-aVCsWLp-ls+sHacVFISCLLPHPsEYuRVGGHW-T.LsS+ToHLKEGLpRLlCLlPYEVIop-lW-hVMP+WhEAIsNDVPE+ELsELKI	.....................................cstphs.aPsLpYtsLY.sls.LlDlhPhlphu...shupulh.sh....tslh.FL.pp...-.lppLPhhh..Sslu.shPs......LHpsIlphLsh.hLPhsI...op..+pp..s..stss..SsSShl.MhshQ.YosNPsaHCQ.LLECLMphKppVhKDlLhVIAYGsups+ssAsphLFaYWPshpPshh.pchhh..hphT....sasPhpCQ+.cC.NA.hN.t.AsK.hChD.olSlshu...DpPPPLY..LC.ECupcItt.............-Hsph..hh.....DlLhP.t.p..lShlCp.pKNCpSp.....s+pAlshCFSst.........Csuhp........GN+PlRYCppCHoN+HsschGus.................................a.sp.s..sshphssE...sphVEAVl.......SLL+EAc.hstppphEhscpcpht..p.....................hsssshs.s.....cspstc-p+lLupaGIWhLVuLCT.Ps-sTPsEsLuRLluMlFpWFHsTAYhhD.............DpV..GShlEKL.....KspaVsc...............WLKslCcl+acVhl.C.LLP+P.EaARVGGaW-p..sSpsopLKEGLsRllCLlPYsVIo....ppl............W-plMPcWhEAIps-VP-ppLpEh+.t.............................	0	23	27	48
+14628	PF14777	BBIP10		Cilia BBSome complex subunit 10	Coggill P	pcc	Jackhmmer:A8MTZ0, Pfam-B_35417 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. BBIP10 localises to the primary cilium, and is present exclusively in ciliated organisms. It is required for cytoplasmic microtubule polymerisation and acetylation, two functions not shared with any other BBSome subunits. BBIP10 physically interacts with HDAC6. BBSome-bound BBIP10 may therefore function to couple acetylation of axonemal microtubules and ciliary membrane growth [2]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3].	26.00	26.00	26.70	26.20	22.80	21.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.27	0.72	-4.60	4	68	2012-04-13 10:27:55	2012-04-13 11:27:55	1	3	62	0	48	71	0	65.60	41	58.35	NEW	MuEs..KsshRE....VLPKQG.L.hEDssshVLCKPKLlPLKSVTLEKLEKMQpEAQ-sVRpQE.ApKpp	.............................t.......ll.Pcp..G.La.hE.-.h.hshVLCKPKLlPLKSlTLEKLEKM..p+cAp...cpl+ppc.spp..t................	0	17	22	39
+14629	PF14778	ODR4-like		Olfactory receptor 4-like	Coggill P	pcc	Jackhmmer:Q5SWX8	Family	In C.elegans, odr-4 and odr-8 are required for localising a subset of odorant GPCRs to the cilia of olfactory neurons [1]. Olfactory receptors (ORs) are synthesised in endoplasmic reticulum of the olfactory neurons, trafficked to the cell surface membrane and transported to the tip of the olfactory cilium, where they bind with odorants. Various accessory proteins are required for proper targetting of different ORs to the cell membrane. ODR-4 was the first accessory protein to be described.	24.50	24.50	24.60	29.60	22.90	24.00	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.36	0.70	-5.76	38	177	2012-04-13 12:22:49	2012-04-13 13:22:49	1	5	117	0	110	194	1	313.30	28	78.69	NEW	GLllGp.tssp+..saVlplspTPpc-ssss.................................t..shpslDp-Wls-HAppVoRMLPGGhsVlGlal..ls.scsshcpss.hpthpplls.......................tsphhhhhspchspphhlalshss..p.phsC+shshts..ssuoh+PsDaKht..pt.spWhplpsshsl-hhlPlt..tspsst.shc......cplppslphhscplpsuhsl..lsGchhptp..l...........................................................psh.plplllP..............tpsspppstplpsssuslphpGslps+ualps.+solu-.AhpslKpDIl+SLpoRl-lhhDsLhpspsssss....t................................hppLPRRVhhsl.st..............sl.hsDYLFtsEsspcshtphp-lLshphsspslstshE	............................................GLllGp..sspc..shllhhstTP.p-pttt............................................t.p.tslDpcWhs-HApQ.VoRMLPGGh.VlGlal..hs...s.thh.pp..p...phhpplhh.......................tpphhshh..p..pphs-plhlals.ss..+...+hhC+shsh.s...spush+PsDaKap......th.spWhplcCshphshhlPls......tsss..shc......cphppsl.pth..s+.pl.psuhhl..lsGp...lhtpctsL....................................................................................s..tttpt..plpllh.h.......................tssppp.stplp.ssGslphpGslps+Aalps.+splp-.AhpslKcDllpol..tsRh-lhh-slh.sp..tpt....t.................................h.hP+Rlhhsh.ut..............slhhsDYhFtsEsspchhpphh-hLshphp.pth............................	0	38	54	83
+14630	PF14779	BBS1		Ciliary BBSome complex subunit 1	Coggill P	pcc	Jackhmmer:Q32MM9	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS1 predominantly localizes to the basal body and or transitional zone of ciliated cells. It has been found in a heptameric complex with BBS2, BBS5, BBS7, BBS8, and BBS9, termed the BBSome. Mutations in BBS1 can lead to retinal inadequacy [4].	27.00	27.00	38.60	33.40	24.30	22.90	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.66	0.70	-5.41	14	145	2012-04-13 12:46:37	2012-04-13 13:46:37	1	7	104	0	91	136	1	216.40	41	43.55	NEW	KWLcA..phDssusLaThSoClsLuDlpuDG-h+LlluDlG..s.tstph...KLKVa+GsplhoEpsLsDlPoulsoFhh-ppEPRhPsIAVAsGsslhlYKNh+PYaKFTlPuh-lssLEp-lW+pst.tsclss.sLcphL-s.L+s.hutt.pLos+S.caLpLc.c-htuFlppapsssltRposITsMsolKKsou-psulSCLVluTEsG-lalLDspAF....slLhp.......hslsSl........so..Gpas...l-aRlsVusRsGslh..hLRR	........WLpA...hh...-shAslpshSuClsLu..DlpGDG-h+LlluDhu.........t..p.....+LKVh+GstlhpEpsL.slPsuhssFh.h-p.p-.P...+.h.....P..slAlAuGsslalY+NL+PaaKFolPtl..ssh.Et-lWppht.ps.plss...shtp...hLcs.l+p...hst...L.ShpShchL.tl.c.........p-.....h.ttFl..pp...a...+s..pslt+pssI...Tshssl++s.s-csusSCLVlGTEstclhlLDspuF.slltp..................hpls..usPs....hltss..Gpap.l-aRlssusRsGplYhl+............................	0	37	46	72
+14631	PF14780	DUF4477		Domain of unknown function (DUF4477)	Coggill P	pcc	Jackhmmer:Q6NW34, Pfam-B_4074 (release 26.0)	Family	\N	24.90	24.90	25.10	25.70	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.85	0.71	-4.92	18	140	2012-04-13 15:23:06	2012-04-13 16:23:06	1	4	103	0	86	128	0	160.00	28	39.79	NEW	WNchcLppPshsoh......psppshhlcslhtslschlppLpu....pph-pEuAlLsRllY+h+NpF+pp+uapulpplppsLpRLhphsLspslpslpshLPs......sspstssslPo+sslEalLVRlLGhsKLhhRlh-sCppAhphhspplp.saFhphsslhhuhluRla.lL.s+slhppsssLYscLhs	.........................................................................hh..hpp.....ptLptEssll.ptllYpp+Nphtppp.ahtLppVcpsL++LpphsLpsslpsl........hplh..ss............................pst.th...lPo......ps......s.....h..-......h.lhh+lLGss+LlhRlh-sCpcshhhhsppLthp.Fh.hsllhhulluRlh.lL.hptlLtchh.lYp.L..t.......................................	0	21	37	62
+14632	PF14781	BBS2_N		Ciliary BBSome complex subunit 2, N-terminal	Coggill P	pcc	Pfam-B_5448 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [5].	26.30	26.30	27.80	32.80	24.70	23.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.62	0.71	-4.54	26	130	2012-04-13 16:13:47	2012-04-13 17:13:47	1	10	98	0	86	119	1	128.20	45	19.35	NEW	l.slG+aDGppP..sLssAT.suGKVhlHsPappttts............ppsslshLNlNpploulsuGtLp....ssspDhLllGoposllAYDVcpNsDlFYK-lsDGlNulll.G...plus..ppPLsllGGNCulpGFDtcGsEhFWTVT.GD	...........................slG+aDGh+P..sLssAT.puGKVhlHsPHppsth.st..................s.cuclshLNINpslosLsAGhLps......p.shDsLllGTpTsLLAYDVhsNsDlFY+E................ls.DGsNul.llG................pl..Gs.....hss........PLsllGGNCulpGFDt-Gs-lFWTVTGD......................	0	36	44	70
+14633	PF14782	BBS2_C		Ciliary BBSome complex subunit 2, C-terminal	Coggill P	pcc	Pfam-B_5884 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [5].	25.00	25.00	25.60	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.15	0.70	-5.91	25	156	2012-04-13 16:18:48	2012-04-13 17:18:48	1	11	100	0	98	140	0	345.70	40	60.16	NEW	oGEVlaKDshsu..ulAulltuDYRhs.GpspLIssSlDG-VRGY.........sstpppssthpsssppctlccL.p+KQsLhhELcshEcshctt..............tssspsshIPssTplpsslpss.....ppspl-LsluTsN...-olI+usllFA..EGlFc.GEoaV....pssssosslclsLhss..+Dssl-l+lKshVGhp.sSspa+VFElohpLP+FsMYthspss.s................pPsuhVsFpls-..RhpRlshWlspsF..hlsptlp.......tssshclphhsLR...ssps.Lhlchssss.........plpIpoDch-lAGDllQuLssFl......slc.-lpspu-FPtphccLcplLp+Vs-hpulRt+Lou-hADpushlKslllRAEDARllsDhcsM++hYsELhslN+-LlspaphRssN+scLlssLKclNphIQ+Au+LRlGpsKspllusCRsAIKsNNlpuLhcII+	..................................sGEVlaK-shsu..slAullpuDYRhs.Gp.pllssos-Gc.lRGY.............stt.psshhtts.ppphlccL.p+KQsLh...............hELpshEpp.t................tttsphshlsssTplpsshtsp.....ptsph-Ltlssss.......sslI+ulllFu...EulFt..GEohl................ss.pp.ss..plplslhss..KDssl-lclKsh....VGht.sus................papVFEloppLP+FsMYth.t.....................P.uhVphtls-..R.p+l.shWlppsF..llsptht.......pttshplpahslR..sst...lhlphp.ss......................plpl.sDshchsG-llQuhstah.......tlp.chps.spFP..hcchpphh.cVcphppl+t+Lou-hA-pushl+shllpAEDARlhtDhpsM+phYhpLhslNp-Llstapl..........RpsNappLhssLKtlNphIppAu+LR.lGpspspllstCRsAI+ssNhpsLhplhp....................................................	0	45	54	82
+14634	PF14783	BBS2_Mid		Ciliary BBSome complex subunit 2, middle region	Coggill P	pcc	Pfam-B_5884 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [5].	27.00	27.00	27.00	27.20	26.90	25.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.34	0.72	-4.29	24	129	2012-04-13 16:52:41	2012-04-13 17:52:41	1	11	96	0	83	119	1	109.30	52	16.03	NEW	sVsulslsDhssDGp..sELlVGS-Da-IRlFcs-.-lltEhsEsstlssLsslps.sp.....FuYuLtNGTVGVYcp...ppRhWRlKSKpp.ssultsaDls..u-G..-LIsGWusG+l-sR	.......................pVpSLsLsDasuDGc.....pEL.....LVGSEDF-IRVFKcD.ElluEhoET-tlTuLs.shhs...u+...............FGYA.LuNGTVGVY...-+.......ssRhWRIK..............SKsc.shulpuFDls..uDGVsELITGWSNGKlDsR.......................	0	33	41	67
+14635	PF14784	ECIST_Cterm		C-terminal domain of the ECSIT protein	Godzik A	adam	Jackhammer:Q9BQ95:268-396	Domain	This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain	25.00	25.00	27.00	27.30	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.62	0.71	-4.18	23	98	2012-04-15 05:32:46	2012-04-15 06:32:46	1	4	81	0	63	105	0	119.00	40	31.59	NEW	SspQpcLLpcpshscPlaVEGPaplWL+cpslsYalL+u-..s.....pshs..p..pp--.hD.....Dssslhhs.h.hhchphpp......p.t.stthoVHEQ-DGTIaA.hCsTGsuo+sSLLuWIRhLpc..sNPsLsplPVlF+Lp	.......SP-QpthLucHsss+PlaVEGPFslWLRs+sl.YalLRAD......hP.p.....-cc.p-.hc.....-..slhhP.h.h.chchsR......psh.shphsl.c-..--GslFA.hChsG.spspsoLhpWIptLQc..sNPsLuplPVlFRL.....................	0	21	26	46
+14636	PF14785	MalF_P2		Maltose transport system permease protein MalF P2 domain	Eberhardt R	re3	CATH:2r6g_F_03	Family	This is the second periplasmic domain (P2 domain) of the maltose transport system permease protein MalF [1-2].	22.00	22.00	22.00	22.90	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.99	0.71	-4.37	57	692	2012-04-16 10:16:57	2012-04-16 11:16:57	1	2	684	8	63	308	12	159.70	61	31.20	NEW	LoaERAQsVLhsRpaQu..GcsasFsLY..ssssp.apLtLpss-ttph.........hlStsFsl..stsss............pplsLs.sss..spGEtAsl+sIspsR..pALsslshhLPsGs.cLpMSuLRpFuuspPLYo............lpcDGpsLpNspoGpha+PNh-hGFYQslstpGpa.tu-plSPGFTVslG	..........................................................................................................LTFERAQpVLhDRSaQA..GKTYNFGLY...PuGDE.WQLALoD..G..E..TGKp..........YLSDAFpF..........GGE..............QKLpLKETsA...PpGERANLRlITQNR..pALSsITAlLPD....Gs...KVhMS..SLRQFSGTpPLYT............Ls.sDG.TLTNNQSGVKYRPNNpIGFYQSIsADGsW.G-EKLSPGYTVThG........	0	11	23	46
+14637	PF14786	Death_2	DEATH_2;	Tube Death domain	Coggill P	pcc	CATH:1d2z_B_00, Pfam-B_14779 (release 26.0)	Domain	This Tube-Death domain has an insertion between helices 2 and 3, and a C-terminal tail compared with the Death domain of Pelle proteins in Drosophila. The two N-terminal Death domains of the serine/threonine kinase Pelle and the adaptor protein Tube interact to form a six-helix bundle fold arranged in an open-ended linear array with plastic interfaces mediating their interactions. This interaction leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis, and is assisted by the significant and indispensable contacts in the heterodimer contributed by the insertion and C-terminal tail described above [1].	25.00	25.00	27.50	32.70	22.80	24.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.84	0.71	-4.46	4	45	2012-10-01 21:41:45	2012-04-16 14:44:21	1	2	33	2	20	49	0	117.20	54	27.18	NEW	YoRsTElR+Vp-.Dl.cLApIL--s..WRpLh.lIP++l.DVptsuGuhh..a..h.....hKYsupp.pplDctApRl..spupuphhl-EWtTSGKLsERPTlGhLLpLLV+uphapAADaVAlchLpEspPARPssGPAAhIsl-	...........ElR+l...th..pLsplL..p...st.W+plMshlPpt.......................hKYoupcl..I-psApRh.PcQStSQlMIDEWKTSGKLNERPTVGVLLQLLVpAELaSAADFVALchLNEspPsRPsDGPuA.ISL-.......	0	5	7	17
+14638	PF14787	zf-CCHC_5		GAG-polyprotein viral zinc-finger	Coggill P	pcc	CATH:1cl4_A_00	Domain	\N	27.00	27.00	27.00	27.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.84	0.72	-4.46	12	108	2012-10-03 11:39:54	2012-04-16 15:14:35	1	20	40	2	36	128	1	33.90	51	5.38	NEW	ssslCPRCtKGhHWAs-C+S+hDhpGpPLss.cpps	....sPsLCPRCKKGpHWAs-C+SKhDhpGpPLss.ptp...........	0	16	19	23
+14639	PF14788	EF-hand_10		EF hand	Coggill P	pcc	CATH:1djx_B_01	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.58	0.72	-4.30	12	227	2012-10-02 16:17:27	2012-04-16 16:04:36	1	18	55	20	99	189	0	50.60	47	6.86	NEW	.KMSh+ElKphL+.lNlElcDpYAcpLFpcCD+SpoupLEupEIEcFY+hLT	..............KMSF+ElpslL+hlNl-hc-pYAhp.LF.....pcs..D+..S.p.o......spLEscElcpFY+hLT........	0	12	24	51
+14640	PF14789	THDPS_M		Tetrahydrodipicolinate N-succinyltransferase middle	Eberhardt R	re3	CATH:2rij_A_02	Domain	This is the middle domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [1].	25.00	25.00	26.00	25.20	20.20	24.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.85	0.72	-4.01	68	856	2012-04-17 07:42:46	2012-04-17 08:42:46	1	5	812	32	164	575	309	40.80	44	11.94	NEW	LsNVAW.TstGPhpl-tlcpsclphRh.pGph.lpVhuVDKFPR	....LsNVAW.TspGPhclstlcpschc...h.....Rh.pG.........t.........h...lsV.sVDKFPR........	0	42	107	149
+14641	PF14790	THDPS_N		Tetrahydrodipicolinate N-succinyltransferase N-terminal	Eberhardt R	re3	CATH:2rij_A_01	Domain	This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [1].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.92	0.71	-4.63	21	296	2012-04-17 07:43:41	2012-04-17 08:43:41	1	2	295	22	35	170	92	135.90	44	36.33	NEW	-cFKshVc-lpup.pGYK-PlAFGIARVDhGQhsucKlLQAoYPllNWc.ENaGSAAlFlpAlpcsGlplDFosSEhVhslspcFlppALphFsPalsEAhu-..uHKNlQVlpsLppthccst......pscF+lVFlFEDssPcSVEulYLKLYALSLuKAsLRSlNLsGAFG	.................................................................................pcFh.hlpphppp.stY+cPhuFGIARlDhu.h.ppKlLpAoasllNap.pNhGShAlhhpuh.pp......t...h..c.ptSEhV..lp.p.l..ALtha.pPalpE...p...uHpNIp....llh..lhct.hc-.s.................................ashVhLaE..DccP.SVEusYLKLhLLSp+KVsLRSlNLsGhFG.....................	0	10	27	34
+14642	PF14791	DNA_pol_B_thumb		DNA polymerase beta thumb 	Eberhardt R	re3	CATH:2van_A_03	Family	The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the thumb domain [1].	25.00	25.00	25.20	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.85	0.72	-4.28	209	1268	2012-04-17 13:11:18	2012-04-17 14:11:18	1	39	923	222	528	1126	238	66.10	35	12.07	NEW	ALhYFTGSctaNhplRphApcc.Gh+LsEaGlac.................sp..........tp..................h....l..ssp.....................oEc-laptLGLsalsPchR-s	..................................uLhaFTGS+paNhphRph.App+.uh+lsEaGlhp....................h..ss..........sp...........................................hl.php..............................................................oEcclactlGlsalsPp.Rc....................................	0	177	300	418
+14643	PF14792	DNA_pol_B_palm		DNA polymerase beta palm 	Eberhardt R	re3	CATH:1bpd_A_03	Domain	The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain [1].	25.00	25.00	25.00	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.76	0.71	-4.01	47	629	2012-10-02 22:47:23	2012-04-17 14:17:36	1	31	308	209	368	663	146	118.30	26	21.74	NEW	RIPRcElptltshVp.ptspplsPs........hpshlsGSYRRGtsoSGDlDlLIT+scspst..................hp.........shLspllppLpp.......psFLscsL...........ut........us............sKahGlCpLss........................s...............thaRRIDlhllPt	..........................+hPRpEspth.tphlp.c.t.s.p.tlsss..........hh.sslsGSYRR.............G+.t.s.u.G.DlDlLlT+sctss........................................p..............tllppllppLcp........ps.alp.p.s..L........................................s.........t.....................................ta.hG.t.h.....................................................................................................hRRlDhhh........................................................................................................	0	113	187	273
+14644	PF14793	DUF4478		Domain of unknown function (DUF4478)	Eberhardt R	re3	CATH:3bq9_A_01	Domain	This domain is found in bacteria, and is approximately 110 amino acids in length. It is found in association with Pfam:PF03641 and Pfam:PF11892.	25.00	25.00	25.20	71.90	19.80	24.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.33	0.71	-4.48	51	869	2012-04-17 14:13:23	2012-04-17 15:13:23	1	3	864	10	131	454	72	111.60	69	24.98	NEW	hpsplsPtGoh-lLSQhEVs+L.ppsususLYpLFRsCuLAVLNoGupoDsucplh-pYp-F-IpllpcERGlKLELhNsPtpAFVDGchIcGIpEHLFuVLRDIlYlssclpp	......Is+lSPh.GSMDhLSQLEVDhL.K+.TA.SSDLYQLFRNCSLAVLNSGShTDNSKELLsRaEsFDINVLRRERGVKLELlNPPE-AFVDG+IIRuLQspLFAVLRDILFVtuQIcs....	0	22	52	94
+14645	PF14794	DUF4479		Domain of unknown function (DUF4479)	Eberhardt R	re3	CATH:3bu2_A_02	Family	This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01588.	25.00	25.00	27.20	27.10	24.20	20.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.12	0.72	-4.44	90	1013	2012-04-17 15:01:32	2012-04-17 16:01:32	1	4	989	4	85	461	0	72.60	40	36.05	NEW	tsssstctshE++GsVs+Ihs.tcsspslGaNlFssSshl.plpu.sGpVpLoc-plspLNptLpcsGFsppLpsDh	..........tpsstuchsh-RKGsVsRlhp.c-sGpsVuaNIFclSs...hl.pIpp..pGpltLTDE.VsplNptlpcsGFsccLssD.......	0	18	42	65
+14646	PF14795	Leucyl-specific		Leucine-tRNA synthetase-specific domain	Coggill P	pcc	CATH:1h3n_A_03	Domain	This short region is found only in leucyl-tRNA synthetases. It is flexibly linked to the enzyme-core by beta-ribbons structures [1]	25.00	25.00	38.20	83.10	18.90	16.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.66	0.72	-4.11	9	12	2012-04-17 15:26:50	2012-04-17 16:26:50	1	2	12	10	6	14	0	55.90	70	6.37	NEW	.WTDaGPVEVEGspVR.LsEssRlRLEl.EutLSLE-V+KMGAELRsHEDGTlHhWKP	WTDFGPVEVEGstVR.LPEPTRIRLElsputLSLE-V+KMGAELRPHEDGTLHLWKP	0	1	4	6
+14647	PF14796	AP3B1_C		Clathrin-adaptor complex-3 beta-1 subunit C-terminal	Coggill P	pcc	Pfam-B_195384 (release 26.0)	Family	This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules [2].	27.00	27.00	27.40	27.50	25.70	26.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.77	0.71	-4.50	25	196	2012-04-17 16:02:19	2012-04-17 17:02:19	1	7	100	0	118	173	1	141.10	38	13.89	NEW	s+ss.s.LLDL.DD.......sPsssP.....lloPSLsusLpshohosssssss............lsuPual...sh+spELLp.+loGcGLulpYRFoRpPplauspMVSlplpFoNpospclpsI+lup+.pLsuGMplpEFspIsp.LtPptShosslGIDFsDSTQ	................................................................s..tpph.LLDL.-Dat........s.ss.P......hlosSLhuDLpGLslosos.s.s.............................lhoP..shh...ssKppELLH.+h.s.GcGLulcYpFsR....p....Pph.......hs..spMVo.....lplphsNso-.p.pIcsI+lGpp.cL..ssGh.plpp...Fs.I-s.LtP.tt.o..hT.sshGIDFsDSTQ................................................	0	25	42	75
+14648	PF14797	SEEEED		Serine-rich region of AP3B1, clathrin-adaptor complex	Coggill P	pcc	Pfam-B_195384 (release 26.0)	Family	This short low-complexity, highly serine-rich region lies on clathrin-adaptor complex 3 beta-1 subunit proteins, between family Adaptin_N, Pfam:PF01602 and a C-terminal domain, AP3B1_C,Pfam:PF14796.	23.00	23.00	25.70	24.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.39	0.71	-4.00	16	46	2012-04-17 16:15:25	2012-04-17 17:15:25	1	3	27	0	20	41	0	130.00	69	12.64	NEW	sssKKFYSESEEEEDSSDSSSDSESESGSESGEQ...sEEGDSoEDSSEDSSSEQDSESGSESEsEsKRsAKRNSKoKGKSDSEDtEKENEKSKTSDSSssESSSlE-SSS-SESEStSESESESR+VTpEKE	...NsuKKFYSESE.....E....E..EDSSDSSSD..........S................E............SE..SGSE.SGEp...sEEGDSSEDS...SEDSSSEp.-SESGpESthEsKRsAKRNSKsKGKSDSEDGEK.E.NEKSK...TSDSSsuESSSlE-SSSDSESESESESESE...SRKVTKEKE.....	0	1	1	4
+14649	PF14798	Ca_hom_mod		Calcium homeostasis modulator	Eberhardt R	re3	Jackhmmer:Q86XJ0	Family	This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels [1].	25.00	25.00	30.70	27.20	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.78	0.70	-5.42	30	292	2012-04-18 15:03:15	2012-04-18 16:03:15	1	2	49	0	174	237	0	231.90	33	77.89	NEW	M-pa+hlhpahpspcsolhsullulLTluupclFShhsFpCPCssshNhhYGlshLhlPAlsLhllGhhlNspo......W+lssG.............+.hpptppssh.hhlhssIhtpAhlAPlsWlsVuLLsGpaY.CAhSs.ssssth....t.hss...psscstchLu+lP.Ctc.hss.....pcplhphL+spSQlLGWhLlsllslluhl.spClppChS.loaLQhcaWppYhcpEcc....lF-ppsppHAcphAccNl+pFF-shpsp.	......................-tFphlhpah...spptslh.ulhulhsluutplaSshsFpCP.C.sshN.hhYGhshLhsPslsLhllGhhlNsps......WchhsG.......................ppt.p..ssth..hhhhsplhtp..AhlAPlsWlsVsL.LsGp.....h.a..CAhSt..ssspth.......hsp....hp....sspstchLs+hP.Ctc..h..s.......p.ctl...hthL+spSQhlGWhllhlsslhshl.spslppChS...l.oaLQtpaWppYhppEcc....lF-psspcHActhAcpslcpFFtthp..p.............................................	0	21	35	73
+14650	PF14799	FAM195		FAM195 family	Eberhardt R	re3	Jackhmmer:C9JLW8	Family	\N	25.00	25.00	26.30	25.60	23.40	23.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.48	0.72	-4.15	32	165	2012-04-19 08:00:36	2012-04-19 09:00:36	1	2	77	0	90	155	0	98.80	36	68.81	NEW	.pssssP+sVFpp.ss+ph.....tts.pptpp......pEshostHEE.l+aIp-uWppV.pp.tts.....................................sss......tstpusshYhpcsPsssLpsFpPhDLEpWWucRhhsNIsp	...........................................................h.pssss+hVap....Nu+Rt......ss.s.s.pss.....pEsaTssHEENVRFlhE.........AWppVppphpst................................ss......tpssts.pYh.EcsPsPpLpsFpPhDL--aWupphhssIt........................................	0	16	22	55
+14651	PF14800	DUF4481		Domain of unknown function (DUF4481)	Eberhardt R	re3	Jackhmmer:Q5VZI3	Family	\N	25.00	25.00	26.70	37.70	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.93	0.70	-5.51	5	86	2012-04-19 09:33:35	2012-04-19 10:33:35	1	3	66	0	51	93	0	236.00	39	63.81	NEW	WRNGQsVhuVPTSShhoP.SFDLSlCRsLLEocGFQIPAu-FEsPLElALDcPSVRRYLlFNSplF+FIMAPIlYlVlWCAlYSTLHLY...SlucYWlLCLsVSLVSIhLTssIlLIlcYSNKEINMNTDVRLluVNERLlRH+LLLGVADWVcsCpGsLQLFhVYWDlu+CL+uLTEoL-EM+FupDpuQphL+KRMSHLlLVsEVsoh-PsA..u....sEG.S-..EEpPLLsusEE.suE.polSQR-DoKLTcNaSLVP-shLsspshApQLLlsYGAlYVRLLVSs+L.sssppPpssu+NHCsuu.slChCQYIc	.............................................h..NGpV.lss.L..hs.s....hhsPhtFc.ths.EpL.s.Glp....lss-pYhshhEohl.-..hhRahlYN.p.hRlhh..s..hlh..a..lVlhu.laS...s.......Qhh....uLushhs.uhLhlshA.Al.LshhlhLhhp+tpcKhNhNh-hpLAtsNttLhRH+lLLGlsDpschspphlpLhFlYFDhppCVpaLs-alp......chcpst.-..sh....hcp+Ls.....................................................................................................................................................................................	0	11	15	31
+14652	PF14801	GCD14_N		tRNA methyltransferase complex GCD14 subunit N-term	Coggill P	pcc	CATH:1i9g_A_01	Domain	This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [1]. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.	21.90	21.90	21.90	22.50	20.70	21.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.70	0.72	-4.39	11	435	2012-04-19 10:01:56	2012-04-19 11:01:56	1	2	432	1	112	324	79	53.60	53	14.52	NEW	.RRGsLpAGEKVQFTDRKGKKITDQLVsGGVTQTEHGlILHDDVIG+oEGsVlT	.....t..pGPFpsG-RVQLTDsKGR+aTlsLpsGupFHTH+GultHD-lIGts-GoVV....	0	33	82	104
+14653	PF14802	TMEM192		TMEM192 family	Eberhardt R	re3	Jackhmmer:Q8IY95	Family	The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome [1-2]. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time [3].	25.00	25.00	25.30	25.00	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.48	0.70	-5.51	19	137	2012-04-19 10:17:44	2012-04-19 11:17:44	1	2	88	0	80	139	0	206.00	32	76.71	NEW	D.ss.hhsssLtSt..cspFcslsTVhhssl.llls...lslslsuhlhshhhsspptcC........csahlllYh+sshWllshlh-phs+p+HpplRhpGYhcFYRpTpph++lPLhlhShsNssLLhltslhpphh...............tpsh.t.t.....Loshhaltlls.lEhllhlsshlhYhs+Vh+FN+t+s.PDlhc--ph...h..s.phssphGh.pcusshEEllEKQADlIcYL+cHNspLu++lhpLs	...........................................................h.t..h.s...p.pFp.l.Th.hhslhhhlp...........shlshhshhhs.h.....tp.pC................ps.hlhlhh+shLWllphlh-palph.pHp+lR.pGYhphacpT+pl+plPLhlhShGNsslLllhsh.tph................t.sh..........L...hhlslhs.lEhlsshhshhhYhs+..lp+.FNpt+spPDllcppt..........s.phhsphGh...+pssshc-llEKQuDhIpYL+cHsthLsc+lhth..........................................................................................	0	16	28	57
+14654	PF14803	Nudix_N_2		Nudix N-terminal	Eberhardt R	re3	CATH:3cng_A_01	Domain	Ths domain occurs at the N-terminus of several Nudix (Nucleoside Diphosphate linked to X) hydrolases.	25.60	25.60	25.70	25.80	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.89	0.72	-4.26	89	442	2012-04-19 11:54:43	2012-04-19 12:54:43	1	3	377	4	170	392	347	33.50	47	17.74	NEW	+aCspCGss.l.ph+lP.tGDs+.RhVCssCstIHYp	......+FCstCGps.l..tt+IP..tGD..sR.RhVC..s..s.CusIHYp...	0	43	94	138
+14655	PF14804	Jag_N		Jag N-terminus	Eberhardt R	re3	CATH:3gku_C_01	Domain	This domain is found at the N-terminus of proteins containing Pfam:PF13083 and Pfam:PF01424, including the jag proteins.	25.00	25.00	25.40	25.10	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.10	0.72	-3.95	270	1458	2012-04-19 14:54:28	2012-04-19 15:54:28	1	7	1341	3	281	989	174	51.90	36	17.81	NEW	chpG+Tl-EAlppAhpcL.sls.c-cl.-l..-Vlpcs.spGhhG..lGpKsAhlclphc	......hpGpTlEEAlppuLppL.sl....s.+pcl...cl..cVlpc..s.+KGFLG..hG.+KsAhlclp.....................	0	137	226	247
+14656	PF14805	THDPS_N_2		Tetrahydrodipicolinate N-succinyltransferase N-terminal	Eberhardt R	re3	CATH:3gos_A_01	Domain	This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [1].	25.00	25.00	25.20	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.31	0.72	-4.11	262	1625	2012-04-20 07:44:11	2012-04-20 08:44:11	1	6	1605	15	423	1040	1377	68.40	52	24.78	NEW	spLpphIEsAaEs.Rspls..t....sssscl+cAVppslshLDsGplRVAE+.h...s......Gp............WhVNpWlKKAVLLuFRlp	.....................pLpslIEsAFEc..RApIo..ss.....sscstsR-AVppsIshLDsGtLRVAEKh....D..............Gp................WsspQWLKKAVLLSFRlp.........	0	118	254	339
+14657	PF14806	Coatomer_b_Cpla		Coatomer beta subunit appendage platform	Coggill P	pcc	PF07781	Domain	This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.	25.00	25.00	29.80	29.20	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.62	0.71	-4.44	30	371	2012-10-01 20:40:43	2012-04-20 16:04:06	1	9	303	0	267	372	4	123.70	54	14.51	NEW	uDcssVlLNDIHIDIMDYIpPAp..CsDspFRsMWsEFEWENK.VsVpT.sls.sL+sYLcHlhcsTNMpCLT...P-uuLsG.-CsFLuANLYA+SlFGEDALANlSIEK....sscGpIsGalRIRSKTQGlALSLGD+Is	...................................s-pssVlLNDIHlDIMDYIpPAs..Co..-spFRp.MWsEFEWEN..K.VsVso.......sh...p..........sL+-aLpclhcuTNMpCLT.................P......c...t.........u........L........sG....c.............CtFluANLYA+Sl.FGEDALANlSIEK.............ts-u.l.sGal.RIRS.KoQGlALSLGD+l...............................	0	99	154	223
+14658	PF14807	AP4E_app_platf		Adaptin AP4 complex epsilon appendage platform	Coggill P	pcc	Pfam-B_21377 (release 26.0)	Domain	This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.	27.00	27.00	29.90	28.50	26.50	25.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.34	0.72	-3.80	12	75	2012-10-01 20:40:43	2012-04-23 09:50:09	1	2	55	0	53	74	0	102.90	41	9.81	NEW	RPLploT--FGthWhSh.up-hcQslp..psstsslsshLpthpppL+LHsVplIGs....EsIhAspLLssss......CLlHs+lsus.slslhl+osspsLs-slltpCppshp	....RPLpIoT--FGchWlSh.us-sKQslp..spot..ssLs.ssLp.sLpp+LpLHlV-lI.Gs....EGllACpL.Lsohs......CLLHsRl.....pus..sluLWhRSssssLsDhLLhpCQ+sh.................	0	22	26	36
+14659	PF14808	TMEM164		TMEM164 family	Eberhardt R	re3	Jackhmmer:Q5U3C3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 214 and 330 amino acids in length. There are two conserved sequence motifs: LNPCH and DPF.	25.00	25.00	25.30	26.70	20.40	21.40	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.59	0.70	-5.18	10	165	2012-04-23 10:24:12	2012-04-23 11:24:12	1	5	104	0	108	146	1	193.00	37	75.81	NEW	hhDWsYGGVDsSls.GNGGPECAsFLospQRllEollhhsLuhhtlhhulc+lt.................spsssttppcssu+plLLlhLslsFGlElGFKFAo+TVIYLLNPCHlsTslQIYLLAss.PS+psTslFRLpMahLNGAlLAlLFPllNTRlLPFEhEIYYIQHlLla.VVPlYLL+hGGsYssEPlsDapWulLuhGLhhhYHFslLQlLullTpVNLNNMLCPAlSDPFpG.aYRIaAssHQsLLshlpuKLhshlh	..........................................................................................................h........................hhs..p+hhE.hhh..h.hh.hhhsh..h......................................tp..c.hllh.....hhsh.hhuhphuaKhsp..t....ph..l....ahLpPCHlho..hhp.l.hlLhh.........p...hshhlF..pl..hthl.GshlAhl.FP.h...ssRhls.hEhthYalQHhhlh.llPlYLlh..sG.sYs...........Esht..shtWshl..u.........hulhhhYHFshLp.lul....h..............TtlNLNpMLCP....A..hpDPF.......G..YRlhA.hHQslhh.hhsKhhhh..s...................................	0	50	56	84
+14660	PF14809	TGT_C1		C1 domain of tRNA-guanine transglycosylase dimerisation	Coggill P	pcc	CATH:1iq8_A_02	Domain	This short region of the tRNA-guanine transglycosylase enzyme acts as the dimerisation domain of the whole protein [1].	25.30	25.30	25.30	110.90	25.20	23.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.34	0.72	-4.16	5	13	2012-04-23 10:52:57	2012-04-23 11:52:57	1	1	13	8	11	15	0	70.00	73	12.05	NEW	PITKKSAFFKISEESL+WPIVRRAKERAERVsuKFPEpVcHPIFGEIPKYLSLTYPFAQSEuEEDFoIEK	PITKuSAFFKVSEEuL+WPIVpRAKERAERVppKFPEslpHPIFGEIPKYLSLoYPFAQSEGEEDFTIEK.	0	1	1	6
+14661	PF14810	TGT_C2		Patch-forming domain C2 of tRNA-guanine transglycosylase	Coggill P	pcc	CATH:1iq8_A_03	Domain	Domain C2 of tRNA-guanine transglycosylase is formed by a four-stranded anti-parallel beta-sheet lined with two alpha helices. It has conserved basic residues on the surface of the beta-sheets as does the C-terminal domain PUA, Pfam:PF01472. The catalytic domain, TGT has conserved basic residues on the outer surface of the N-terminal three-stranded beta sheet, which closes the barrel, and it is postulated that these basic residues from the three domains form a continuous, positively charged patch to which the tRNA binds [1].	25.30	25.30	25.50	26.50	25.20	24.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.27	0.72	-4.13	62	193	2012-04-23 13:13:56	2012-04-23 14:13:56	1	5	144	8	131	194	27	71.10	29	20.27	NEW	lpplRsIADYQFGtGAGcsLFs-p...hplphS.pTG+lRplhsssc.plATl+usDGhhoLultGAcRLpcshshPp	.....................tl+slA-YQFGtGsu.c.tLhsct....hplphS..pTs+l.Rplh.....t.....s.........sc..pls.olRupDGhlsLoltGAchLpphh..P..........	0	31	81	109
+14662	PF14811	TPD		Protein of unknown function TPD sequence-motif	Coggill P	pcc	Jackhmmer:Q9Y2V0	Family	This is a family of eukaryotic proteins of unknown function.  A few members have an associated zinc-finger domain. All members carry a highly conserved TPD sequence-motif.	27.00	27.00	29.60	30.20	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.81	0.71	-4.65	33	149	2012-04-23 14:17:28	2012-04-23 15:17:28	1	2	114	0	101	150	64	132.30	41	47.79	NEW	ls-pcLtt-ltpsl..hsDp.huPls-ph+.......cshGpEaEhhLcchLcptslsFhsEcc.LRtpGasK........TPDl+LplPlslcGp.....lVsWIESKA.FGD...pcsH..pphhccQh.uYhNRFGP.GhVIYWaGal-.....pl..sp..t.........lll.........hD.pFP	....................................D.hLutpl.pCl..hsD.stauPlsDph+.......+shGpEaEhhLcchLhptsl...sFhsEcp.LRtcGYDK.........TPDhhLp...lPl......ul..cGp.........................llpWIESKAsFGD.......cpoH....psa.lccQahSYhNRFGP.GhVIYWaGalp-l..st..p...tlhlhs.t....................	0	43	56	78
+14663	PF14812	PBP1_TM		Transmembrane domain of transglycosylase PBP1 at N-terminal	Coggill P	pcc	CATH:3fwl_A_01, Pfam-B_367 (release 26.0)	Family	This is the N-terminal, transmembrane, domain of the transglycosylases ()penicillin-binding proteins), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The TM domain is a single helix, several of whose residues lie in close proximity to hydrophobic residues in the TGT domain. The TM helix seems to be necessary for stabilizing the protein-membrane interaction, and the resulting orientation limits the interaction between PBPb1 and lipid II in the membrane in a 2D lateral diffusion fashion [1].	27.00	27.00	27.00	27.00	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.37	0.72	-3.67	26	562	2012-04-23 14:23:22	2012-04-23 15:23:22	1	8	557	2	46	248	3	78.00	74	9.53	NEW	MS.sDDREPIGRKGKts..pss+ppss.+pRRRcDD.....................--..DDD..p..E.--csMsRKsKs......p.s+pKR.RW.LhLLlKLhlV.FsVl	............MA.GNDREPIGRKGKPo..RPVKQK..VSRRRhcDDD........................D...D..D.YDD....E..DEEPM.PRKGKGK........GR.KPRGKR..GW.LWL.LLK..LhIV.FAVL................	0	3	11	28
+14664	PF14813	NADH_B2		NADH dehydrogenase 1 beta subcomplex subunit 2	Eberhardt R	re3	Jackhmmer:O95178	Family	This family represents an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis [1-2].	25.00	25.00	25.90	27.00	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.59	0.72	-4.31	12	105	2012-04-23 14:29:09	2012-04-23 15:29:09	1	2	86	0	61	100	1	69.70	46	65.04	NEW	u.stusHl.shYRphPp.ls+tphhtuElluGhMWaWlLWHhWH-s-tlhGHFsYPDsSpWTDEELGIPPDDpE	.................u.tusHl.spYRphPp..lT+p...phhtuEhh.SGhMWFWILW+hWHDs-t.VlG.HFPYPDP..SpWTDEELGIPsDDt..............	0	16	21	42
+14665	PF14814	UB2H		Bifunctional transglycosylase second domain	Coggill P	pcc	CATH:3fwl_A_02	Domain	UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle [1].	27.00	27.00	27.00	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.38	0.72	-4.26	119	1054	2012-04-23 14:40:43	2012-04-23 15:40:43	1	9	1036	2	158	684	84	84.40	46	10.57	NEW	LhsGtslotpplhpELchLsYRps.s.p...sp...psGpa......shpu....splplhpRsFsFsDG.t.Essp+lplsFss.splsplpshps.sp.shuhhRL	.......LcPshslS+sEhlplL-uhpYRpV.o.p...hs...+PGEF......oVpu....so.IEhlRRPF-FPDu.c.Eup..hRsRLoFss.s+LusIhsh-s.sR.phGaFRL................................	0	32	68	118
+14666	PF14815	NUDIX_4		NUDIX domain	Coggill P	pcc	CATH:3fsp_A_03	Domain	\N	35.00	35.00	35.00	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.66	0.71	-4.65	286	3169	2012-10-02 00:00:35	2012-04-23 16:31:00	1	22	3080	6	661	3685	1180	115.00	24	31.12	NEW	shl.lhp.pssp..lL.Lc+RPspG.LhuGLaphPph.-....h..t..................tp.th.................t..t.h...tp...h.shp...sp..h.h.p.....hs.....shcHsFoH.acLcl..p..shh....spls.....pt....t...........s.sshhWhshpp.h.p.p..huLPsshcKllp	........................................hllhp.pp.sp...lLLpc.RPsp...G........L..h.uGLapF...Pt.h.c........t...................p........tppl.........................................................p..p.ht.....pp....h..s.h.s.......ss.........h......p......phs.......slpHs........F....S........H..h+l..cl....pshh..........spls.........st..tst...........................ssshhWhshpp..h.s..s....hulssshc+lh...................................................................	0	191	386	534
+14667	PF14816	FAM178		Family of unknown function, FAM178	Coggill P	pcc	Jackhmmer:Q8IXR5	Family	\N	25.00	25.00	25.10	30.60	23.40	22.20	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.42	0.70	-5.75	7	112	2012-04-23 16:07:15	2012-04-23 17:07:15	1	2	42	0	51	106	0	318.10	44	44.42	NEW	tuusphspspusoYsNoL-aLLQEKcp.th.pEhE+.Lhp-h.php..s.D...t-Es......sLs.EHRtllcRFSVohpuIPshHPGEsVF.......l.ppasLs..LcpSplpP+StlEpLhLpSssspQLohlppGLLoshYhpss.CPlslL+WLFQhhoh.P-..sSsthhuhLa-lolcuh.p.oDpssp...hWsPSLp-VstsFashGA+..uLaPLsshQ.sh..csLhuchphopscpQ..ssssphu.DhS......LtplhKFLsLCshspPsAYTDppLLhLItLLC+huL-spL+LLPpsDhQpLLl.LLcNIp-WssKlppLCpsLSplSsHHHNLLtLVQlhP-hoSRuRpLRppLSLVlIA+hLsppcph	...................................................................................................................t..pYhNsL-hLlpEhccp.....t..h..pEh...pc.L.p-h.ph...p.........p.s...t-p.............sL........EHR.hlc.+FSVo..l.psIPshHPGEplF.......l.pp.asLs..Lc..sSthhsp..SslE...pLhL.pSs.spQl.hhppGhLoshY.h.as...CPlPlLp....WLFphhoh.s-..sSsphhuhLh-l.olcs....p...s.Dpshh.....WhPSLp-lstlFhshGh..p..uL.aPLtshQ.sh..csL.....h.u-.sph...o.ttpp.....stspp.ht..hS............lhplh.KFLu.LCs....plpPp..uYpDp-lhhLI.hLh+h.uL-tpL.+.lP.hsDhQpLLl.L.hcNI..+-..WssKl.cLChulsplSsH.HNLLhLVQhhPshToRuR...QLRp.pLSLVlIu+hLsppc........................................	0	7	11	19
+14668	PF14817	HAUS5		HAUS augmin-like complex subunit 5	Eberhardt R	re3	Jackhmmer:O94927	Family	This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].	25.00	25.00	25.30	25.30	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	632	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.22	0.70	-5.98	8	103	2012-04-24 09:49:48	2012-04-24 10:49:48	1	6	59	0	65	103	0	479.50	25	90.83	NEW	p.ucELtRWAsEEMslPsuu..........tPs-sth++LClGpGAcIWtYllpHV+SpRoV+sIRGNLLWYuttsss...................................clp.........R.........+hELppplpcLRAElpcLDpplpthEpEssup-tuhppuh.......pphp-sp+RpLLLcAastpsc+pp+sLp-shp+LpsQhcpLQ-hpR+Acs-...lsFGsss...SAu...................suLEPtVLRDVRcACshRspFL....QsLLpspsptsSshssp........cDphusSaQpWh.....SuVEslLss.....HPPsplLuALptLsucpcsplcp.LsosD........shp.Ds.....Ehp+........sphsD...................pScsppsLPuhppLlQEuWppVspllsppuplpp..cpQsLsp+LpuhlcEsccc.hlsS.sppssh..............hhpL..cpsslhsslc.uL+spsppLpptsuc+pctl.......RpLQsppQpIh-aRpLs-c+QEQIRhLIK.GNSuuKocLsRsstEltphlpcKLlPshpsVsspSpcLpcslpcEs+HFsplsLu..................................sLh+ppssGhphlPssh.SIHRL.pst..h.......suuhtsLscoLulPh.h+APEtLLspAsoh+p-LlaLpcphuLpupuLhs..l..+suL.Pus..sTQtLLphtppp-Kcph-sLsPpL++LhppscpsLEts.plQullsDWWEQPuQhALsp.pppGLolpQWppR	..............................................................................................................................................tWh.pEhth...............s....t.h....pplChG.p.hh.lWtalhp+Vhppcslphh+tNl..hat..t.t.................................................tht......c..........+..htt.tltpLcs.ltp.ppp.lp.h..pht..tp-.thpp.h.......tphtp.pp+thhLpu.ttthptttp.htp..pplp..hpphpch.t+.tt..t......h.............t...............................hhEs.h.tslRthCp.h.t.h....ptl..s..t.ts.................th.htthh......p.sp.hhts.....hsP..lLtulthhs.c.tt.lpp.hpths........hht-h.....ch.p........................h.s.........................usp....hss..pLlpcth....ttlt.hhsptt.h.p...ptp.hppcL.thhct......hptt..h.t....t.......p...t.tsh...............hhth..chsshhuplp.sLhsps..ppLpphstppp.h........ppLpt+.pcI.cacthhpchpp.hphLl+.uN.sutshhppt.hts.thht...tpllP..t.l...spp.hphlpcEhtth.t...s..................................sl.ptpstt.....Pshh.SIp..pl..psh............................................s.shh.l.ptLths....pusE..h.tshsht..p.hh.hhpp.....t..l.p..h.....tst.....t...stp.hlph.tpp-p...cphh.tl+ph...hppshp..h..lpshltcWa-QPuthsls...h..tG.sh.tW......................................	0	21	36	49
+14669	PF14818	DUF4482		Domain of unknown function (DUF4482)	Eberhardt R	re3	Jackhmmer:Q6ZU52	Family	This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF11365.	25.00	25.00	25.40	29.70	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.85	0.71	-3.53	13	155	2012-04-24 10:34:25	2012-04-24 11:34:25	1	3	38	0	83	137	1	130.10	34	10.45	NEW	MDL+cQlcpoE+NWp+EKhELL-+FDsER+EWEsQhK.hQ+KIEcLp+EVchRRp.......uphhs.p+-pshpspshpusss.Ppsup....s-hpuhspcDshtpcpKcppslhupp....................s.hscp.phsccscsshhss.sh-.cK	...........................MDLppQlp.poE+NWs+EKlELL-RhDpERppWEpQhKE...Lpp+lc......Q............LpKtsssh......................sl+.t.hptp.p..c..st...h.pDt-shs.t-h.hsphKcscpsou..p....................s.hhcshpLsspst.s..t...h-.p......................................................................................................	0	6	11	31
+14670	PF14819	QueF_N		Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term	Coggill P	pcc	CATH;3bp1_A_01	Family	The QueF monomer is made up of two ferredoxin-like domains aligned together with their beta-sheets that have additional embellishments. This subunit is composed of a three-stranded beta-sheet and two alpha-helices. QueF reduces a nitrile bond to a primary amine. The two monomer units together create suitable substrate-binding pockets [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.42	0.72	-3.98	126	1208	2012-10-01 20:59:24	2012-04-24 16:18:52	1	5	1189	25	217	794	335	110.50	60	39.70	NEW	Y.spYDPsLL.PlPRshsR-pLGlss..sLPF.p.GtDlWsuYELSWLNs+GKPpVAluchplPssSsNLIESKSFKLYLNSFNQT+Fso.hcpVppplpcDLSssAsusVsVpl	......................................YtcpYDsSLLQsVPRoLNR-sL....G.....Lpu....psLPF.p.GsDIWThY...EL.SWLN.u+GlPQVAlGclplshsSsNLIESKSFKLYLNSFNQTRFss.....h-p.....VcpTLp+DLSsCAtupVoVpL..............	0	41	94	159
+14671	PF14820	SPRR2		Small proline-rich 2	Eberhardt R	re3	Jackhmmer:Q96RM1	Family	This family of small proteins is rich in proline, cysteine and glutamate. They contain a tandemly repeated nonamer, PKCPEPCPP [1]. They are components of the cornified envelope of keratinocytes [2].	25.00	25.00	38.50	26.20	21.80	23.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.64	0.72	-4.10	4	108	2012-04-25 10:24:47	2012-04-25 11:24:47	1	3	16	0	43	102	0	59.60	78	98.41	NEW	SYQQQQCKQPCQPPPVCPsPKCPEPCPPPKCPEPCPPPhC.PEsCPP..CQcKCPPV...PPCQpKCPP	........SYQQQQCKQPCQPP.PVCPsPKCPEPCPPPKCPEPCPP.PKC....PEP.....CP....P.....ppC.....QQKhPPVp..PPCQ.KhPP..	0	6	6	6
+14672	PF14821	Thr_synth_N		Threonine synthase N terminus	Eberhardt R	re3	CATH:1kl7_A_01	Domain	This domain is found at the N-terminus of many threonine synthase enzymes [1].	25.00	25.00	25.00	26.60	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.61	0.72	-3.96	302	3034	2012-04-25 12:31:21	2012-04-25 13:31:21	1	15	2909	4	759	2286	1521	77.50	33	16.58	NEW	cYlSTRG.p....s...sslsFp-slLp.GL.AsDGGLalPc..phPp.lsts.plpphpsL....oYt-LAhclhphFl....s-....Isps-L+sllscuY	..................a.STRs..p........s.......pploFupAllp.GL.Ap.D.GGLahPp..s.lPp.hshs...l.c...ph...tsh..........sa.-hAhclLssFl....s-.....lsp..-pLcphlppAa.................................	0	214	441	611
+14673	PF14822	Vasohibin		Vasohibin	Eberhardt R	re3	Jackhmmer:Q86V25	Family	This family of proteins function as angiogenesis inhibitors in animals [1-2].	24.00	24.00	42.30	25.10	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.45	0.70	-5.29	10	165	2012-04-25 13:13:52	2012-04-25 14:13:52	1	5	72	0	95	174	0	192.10	48	64.09	NEW	GGVPFalNRuGhPls-tTW............ERMWpHVAKhHP.DGcchsp+IRsAsc...LPKlPl................PoVPsF.....psot..oVs-tLcAlQpYl+cLQYNHTGTQFFEIKKsRPLoGLMElAKEMs+ESLPIKCLEAVILGIYLTNuhssLERFPISFKTpFSGsaFRHIVLGla.huGRaGALGlSRRcDLMYKPLpaRTLS-LlhDacsuYccpaHsLcKVKIGtsVsH-PHSsEpI-WKHsVLslp+.hu+EDlRKELE+auRDMR	...........................................s............h....t.hW............ppMa.ashp.ps.pstp.httl+sss....Lsc.sh.................PplPsa.....p.sh..slsphLpslQpYhppLp...YNaTG.sQFFplcK.RPLsuLM-hAKEMh+EuLPIKCLEAVILul......Y............LTsu.ssl-RFPISFKo.F.uG.....sh..........F+HlVLGlh..h...s...G+...Y..GuLGh.SRRt-LM.KPhsa+oLS-Llh-act.uYpphhHslpKVKl.G..VsH-PHShp.IpWKp.lLshp+.hhtt-hc+pLE+asR-hR................................................................	0	28	39	58
+14674	PF14823	Sirohm_synth_C		Sirohaem biosynthesis protein C-terminal	Eberhardt R	re3	CATH:1kyq_A_03	Domain	This domain is the C-terminus of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241 [1].	24.00	24.00	24.00	24.00	23.30	23.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.26	0.72	-4.67	15	193	2012-04-25 14:50:59	2012-04-25 15:50:59	1	7	134	3	147	186	0	66.60	29	18.74	NEW	PcNhGsAl-sVGpLRp+LRc...lAPss..c-GsKRMcWMoplCEtaoL--Lsphs-pDh.-sLLsaahssplsohp	..........................thttAl.plG.LRttlRt.........hsss.........ppts.+..R.McW.................hsplC-hWsLcclspl..s-pDh..csLLphY.psp....p................	0	37	78	123
+14675	PF14824	Sirohm_synth_M		Sirohaem biosynthesis protein central	Eberhardt R	re3	CATH:1kyq_A_02	Domain	This is the central domain of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241 [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.97	0.72	-7.03	0.72	-4.96	20	356	2012-04-25 15:03:26	2012-04-25 16:03:26	1	10	344	3	153	298	5	29.90	43	11.74	NEW	cs.usLQIMISTNGsuPRLuuLl+ccIcptl	.........G.LpIhVSTsGtSP+LAphIRccItsph.......	0	50	98	134
+14676	PF14825	DUF4483		Domain of unknown function (DUF4483)	Eberhardt R	re3	Jackhmmer:Q6ZQR2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 326 amino acids in length. There is a single completely conserved residue N that may be functionally important.	24.00	24.00	24.70	24.40	21.90	22.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.35	0.71	-4.65	27	116	2012-04-26 08:48:36	2012-04-26 09:48:36	1	10	64	0	94	109	0	165.70	23	57.40	NEW	shpsohtpNsLL.hKsclG+sppssasLPstc...asYGhhstt.pstGstEsh.pW.........ptptss.sppssp.........DFhphN+tAlppG.lsTA+.......-.htaRpp+s...l+hKs.t.....stptt.........ptssphssshs...aGhso+sso............PltpllptpYtppahpppttpptthppppp.........ttp.....lttT+AShh......++ht..spspp......aKMs+F.cpVss+lpo	............................................psclG+s+.psh..sLPs.s...asYGh..tt..stGs.-.........sh.pW.............................p.ht.p.st..th..........sahthN+tulptG.hhoup.................-.h.aRp.ps...l+hp.tp......tt.t...........................p.s.thssshs...aGh.s+sso..................shhpllptpYtp.ahppttt.t.ttht.pptpt.........................hhps+us.h..........................ppht...p.pt......a+h.+F.pph..th.............................................	0	65	74	81
+14677	PF14826	FACT-Spt16_Nlob		FACT complex subunit SPT16 N-terminal lobe domain	Coggill P	pcc	CATH:3biq_A_01	Domain	The FACT or facilitator of chromatin transcription complex binds to and alters the properties of nucleosomes. This family represents the N-terminal lobe of the NTD, or N-terminal domain, and acts as a protein-protein interaction domain presumably with partners outside of the FACT complex [1]. Knockout of the whole NTD domain, 1-450 residues in UniProt:P32558, in yeast serves to tender the cells sensitive to DNA replication stress but is not lethal. The C-terminal half of NTD is structurally similar to aminopeptidases, and the most highly conserved surface residues line a cleft equivalent to the aminopeptidase substrate-binding site, family peptidase_M24, Pfam:PF00557 [1].	27.00	27.00	27.50	35.30	23.20	26.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.01	0.71	-4.71	75	332	2012-04-26 15:17:54	2012-04-26 16:17:54	1	12	266	8	243	336	0	156.80	32	16.08	NEW	IDtssFtcRLptLaspWcpsppt.....hausssulllssGt.ss-..-stYpKosALphWLLGY.EFPcTlhlFs..pc..plhhlsSpKKAcaLcslp..p...........s..ssh.slclhsR..stpD...tpspp.Fpcll-tlc...p....sG.pp.lGslsK-..shpGpFh-pWpphhp....ppsh.cpVDlosul	................................lDtpsFhcRlpplaspWcpspp..........aus....ssul.llhsGt..sc-..-..YtKos........ALp..hWLhGY..EhscTlhlFs.....pc..plhhlsSpKKs..............caL....cplp..p.............sut.slpl..l..lRs.p-......pscp.Fccllctl+...p........sGpp.lGshsKD.....p.pGpFhcpWpchhp....ppsh..cplDloss.............................................	0	81	133	202
+14678	PF14827	Cache_3		Sensory domain of two-component sensor kinase	Coggill P	pcc	CATH:3by8_A_00, Pfam-B_120 (release 26.0)	Domain	Cache_3 is the periplasmic sensor domains of sensor histidine kinase of E. coli DcuS. This domain forms one of the components of the two-component signalling system that allows bacteria to adapt to changing environments. The ability of bacteria to monitor and adapt to their environment is crucial to their survival, and two-component signal transduction systems mediate most of these adaptive responses. One component is a histidine kinase sensor - this domain - most commonly part of a homodimeric transmembrane sensor protein, and the second component is a cytoplasmic response regulator. The two components interact in tandem through a phospho-transfer cascade [1].	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.42	0.71	-4.19	258	2633	2012-10-01 23:40:40	2012-04-26 17:59:26	1	59	1299	16	414	1784	44	115.40	31	21.38	NEW	hslAcslApsPtlh..pu..lp..s.ssss...............................Qshscplppp.ssssFlVlhDhpGlRhoHP.sspp...IGcphh.....sD....ptAL.....pG.csasu.p.....spGoL..G.SlRuhsPlh...s..ss....G.cl.lGhVuVGhhhssl	.......................................shAchlAsssplh..pu..lp....p..ps.p...............tl........pshsp.plpc.p...ss..hsalV.lsDt.pul.Rh.sHP....ss..p+....IGpshp...s..sD........tAL....pG....c...p...hs.u..h.............................scG..ol.....G...ul.Rshs..PIh.........s...ps..............G...cl.IGVVulGh.lsp........................................	0	115	250	340
+14679	PF14828	Amnionless		Amnionless	Eberhardt R	re3	Jackhmmer:Q9BXJ7	Family	The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake [1].	26.90	26.90	27.00	26.90	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	437	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.78	0.70	-5.99	16	114	2012-04-27 08:29:45	2012-04-27 09:29:45	1	8	76	0	77	100	0	313.20	24	83.41	NEW	hKhWsssssFssAuNWss.sphPCupDhl.FPuphsssl.l.psh.olsshlLPpsGtllLApsu..hhhuusss.sssCts...ttpAhF+sPcpppWaDPss..Wpstsspsuh.........hss-hERVPCpp..........-cVlF..up.ushplsLp.ssphl+ltplphuGpoho+sp.LppaLuochGphhFH.supslpVp.h+....CspsptCsC...............spschh-hlCusl......pCst..spChsPlRP.GpCC.lCGAllplsps...sshDhcphps+lpcthhppshhp.plphtVuhVsppp.........hssplQllllD..pGs.otpuschhtp.hhtchpsphtshtt.shplptuGpPhssssuhs.............lsshlLhsLlLVullusllLh+h...........p.shls+lspWh+c.chhth.t....thspsFh.spFDsss...........ttsssltpls..............uhcutsspspc.psFsNPhF-p	................................................................+.a...shphpsstsW.p.tthPp.ts.l.Fst......h.l.l.....tsh..tltthhlP.hpGthllsptu...h.h.......s.s..tt....t...........t..h.h.....st....p....WhsPt.Wtstst...........................h..c.EplPCp...........-pVhh...sp.......sshtl..tlt...t.lpltpl.hh..s..pp..hstt..htth.hsp.p.....Gp...Fh...s...ttl.......lt..t.........phC.C...............s...t..........lCt.h.........pC.....stC.tslhP..GpCC.lC..Gu.hl.hpht....t.shpphpttl.phh.......t...tlththphh.p......................lp..hllhc.......tt..st.tht.ht.....tp.tt.h............hph..stt........h..................h..hh...hh.hhhhh.......hh.h........................................................................................................................................................................................................	0	29	34	59
+14680	PF14829	GPAT_N		Glycerol-3-phosphate acyltransferase N-terminal	Coggill P	pcc	CATH:1iuq_A_01	Domain	GPAT_N is the N-terminal domain of glycerol-3-phosphate acyltransferases, and it forms a four-helix bundle [1]. Glycerol-3-phosphate (1)-acyltransferase(G3PAT) catalyses the incorporation of an acyl group from either acyl-acyl carrier proteins or acyl-CoAs into the sn-1 position of glycerol 3-phosphate to yield 1-acylglycerol-3-phosphate. G3PATs can either be selective, preferentially using the unsaturated fatty acid, oleate (C18:1), as the acyl donor, or non-selective, using either oleate or the saturated fatty acid, palmitate (C16:0), at comparable rates. The differential substrate-specificity for saturated versus unsaturated fatty acids seen within this enzyme family has been implicated in the sensitivity of plants to chilling temperatures [2]. The exact function of this domain is not known. it lies upstream of family Acyltransferase, Pfam:PF01553.	25.00	25.00	26.00	48.40	21.00	19.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.34	0.72	-4.29	19	48	2012-04-27 10:01:24	2012-04-27 11:01:24	1	2	38	2	14	50	0	73.80	53	17.95	NEW	+S+oFLcscsEQ-LlSsI++ElEuG+LPsslAsGMEELYpNYKsAVlpSGsPpAcEIlLSNM.sshhDRlhLDVc-PF	........SRsFLcsRsEp-LLusI+KEsEuG+LPssVAsGMEELYtNYKsAVlpSGsPpAcEIlLSNM.sshhDRlhLDVc-PF......................	0	3	9	12
+14681	PF14830	Haemocyan_bet_s		Haemocyanin beta-sandwich	Eberhardt R	re3	CATH:1js8_B_02	Family	This antiparallel beta sandwich domain occurs in mollusc haemocyanins. Each mollusc haemocyanin contains several globular oxygen binding functional units. Each unit consists of an alpha-helical copper binding domain (Pfam:PF00264) and an antiparallel beta sandwich domain [1-2].	24.00	24.00	24.60	24.00	23.10	22.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.09	0.72	-4.32	27	179	2012-04-27 10:19:59	2012-04-27 11:19:59	1	15	36	7	0	211	0	99.90	40	24.82	NEW	R+p+DRVFAGFLLcGltsSAsVca.lCps..s....scC.pc..AGhFhlLGG-tEMPWuFDRLaKYDITcsLcphslc......hc-sFplclplsusNGotLsucll.sPollapP	.........ppc-RlFAuFLLpGItsSAsVph.lCts....s......spC..phAGpFhlLGGp.pEMPWsFDRlaKaDITcsLcclslp......hcssF......plclclhulsGotL.s.ssllPpPolla.P...........................................	0	0	0	0
+14682	PF14831	DUF4484		Domain of unknown function (DUF4484)	Coggill P	pcc	KOGs (KOG4704), PF09804	Domain	This domain is found, in a few members, a the the C-terminus of family Avl9, Pfam:PF09794. The function is not known.	25.60	25.60	27.00	26.20	18.40	25.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.43	0.71	-4.17	13	120	2012-04-27 10:43:25	2012-04-27 11:43:25	1	6	101	0	85	117	0	151.50	27	30.65	NEW	lEPlSWscLAYouFIWWASAGEpc.....cppE..ph-pDopLLAss-sssoP...................................sp.s...........pt.sElulVAYFHRLTsplFssLuDlIscpDsc.....ss.-s-......s........................-s.spD.................tD-s.uPL...................psp.slclTspDhs-MGLDsWSsuDh.FVcElVtpaWGR+AhV-uscIcsCGluIs	...............................................lEPlSWsthhasuFhWWASAGpph........t..p.tpDttlh.t............t.....................................................................................tpsph..tlsllsYF+RLToplhshltDlltppppp....p....t..................................................t.......................................................................ptt.lplsspshtpMsLDsaSttDt.FVc-ls.haa.tRp..h.lpshtlthsh..............	0	13	43	71
+14683	PF14832	Tautomerase_3		Putative oxalocrotonate tautomerase enzyme	Coggill P	pcc	CATH:3c6v_A_00	Domain	4-oxalocrotonate tautomerase enzyme is involved in the anthranilate synthase pathway.1	25.70	25.70	25.70	25.70	25.60	25.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.69	0.71	-4.16	26	117	2012-10-01 20:38:22	2012-04-27 13:13:24	1	3	81	22	87	147	121	130.80	28	84.02	NEW	MPLWpIaHPsssFo.s.p.-KpsLApsITchY........ssh.GLPsFYVsVhFhclsss...shalGGcspss.................FlRIslsH.IARp.........hssc..-p..ppchhp.tlstsLcPal...tD+.GhcWEaHl-EsspcLW+IsGlhPPsssStsE+cWsp-N+	............MPhaplaHs..ssho.s.ppKpplApsIT.p.hY........ssh..sl.PtFYVsVhFh..clsss....shalGGctpsp..................hlpl.hlpH..lu..Rp..........hpst..-t..ppphhp.tlsthl........t.shh........tpc...uhchp........hhls-sshphhh.sGhh.P..tptt...Wht.s.................................................................................	0	13	44	69
+14684	PF14833	NAD_binding_11		NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	Coggill P	pcc	CATH:2cvz_A_02	Domain	3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidized to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold [1].	30.00	30.00	30.30	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.37	0.71	-4.05	132	7339	2012-10-10 17:06:42	2012-04-27 14:05:12	1	47	2857	51	2191	5638	4290	121.10	28	40.35	NEW	GuGpssKhsNshlsAsslhAsuEAlshut+.sGlDspthhcll.su.usupS...ts....h....p......sh......hsphll....s....psF.ssG.FslsLhhKDlslAhsh..ucphsssh.Plsuh.sppla.p.s.u.t.s.p.hs..s.s.t.Daoul.l.+h.l	..................................GsGpssK..lsNphllusphtuhuEA.........hsLA.p+..sGl.c..pt...lh.cs.l........ss.....u...s...u.....s.S......hh.........h.....c..........sp............hst.h....hh...........s..........ps.a....s..P......u....F...t...l.....c...lhhK...D...........L.....slAlcs............Ac....p...hs...h..s.l..P..l.s.ut...s....p.pha.p.p.h...t...s...t...Gh...upt...DhSulhph...........................................	0	558	1233	1760
+14685	PF14834	GST_C_4		Glutathione S-transferase, C-terminal domain	Coggill P	pcc	CATRH:3bby_A_02	Domain	GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants.  Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain [1].	30.00	30.00	30.10	30.00	29.80	29.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.50	0.71	-4.16	7	561	2012-10-03 01:14:49	2012-04-27 14:19:54	1	4	556	1	52	223	10	116.50	75	54.87	NEW	DlQKRARARQlQAWLRSDLMPIRtERSTDVVFAGsKhuPLSpsGptSAcKLhAsApsLLuHGp.NLFGEWCIADTDLALMlNRLlLpGDcVPEtLsDYAoFQWQRASVQRalALSAK	...DLcpRARARQIQAWLRSDLMPIREERP....TDV..VFAGAKK.APL....os....cG.KASA...EK...L.FA...h...AE...+.L...L...u.h.GpsN...LFGEWCIADTDLALMINRLVLHGD-VPEpLsDYATFQWQRASVQRFIALSuK.................	0	5	15	38
+14686	PF14835	zf-RING_6		zf-RING of BARD1-type protein	Coggill P	pcc	CATH:1jm7_B_00	Domain	The RING domain of the breast and ovarian cancer tumour-suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. A dimer is formed between the RING domains of BRCA1 and BARD1. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level [1]. The corresponding BRCA1-RING domain is on family zf-C3HC4_2, Pfam:PF13923.	35.00	35.00	35.00	35.30	34.80	34.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.37	0.72	-4.19	5	67	2012-10-03 15:03:13	2012-04-27 14:43:25	1	22	45	1	38	63	2	62.10	57	9.95	NEW	LDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGSGCPVCYTPAWIQDLKINRQLDSMI	....LtclEpLLRCS+CssI.LREPVCLGGCEHlFCSsCl..uD....ClG..o..s..CPVCaTPAWlQDlKINRQLDuMI............	0	5	8	18
+14687	PF14836	Ubiquitin_3		Ubiquitin-like domain	Eberhardt R	re3	Jackhmmer:Q6K1E7	Domain	This ubiquitin-like domain is found in several ubiquitin carboxyl-terminal hydrolases [1] and in gametogenetin-binding protein.	24.00	24.00	24.50	25.10	23.70	23.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.98	0.72	-4.32	6	283	2012-10-03 10:59:06	2012-04-27 15:38:54	1	13	52	9	133	242	1	86.40	46	9.70	NEW	uhKLClPGhssLpSPlpKtFRSoDTVGFlEuELKKLLul..Q+EoRLWKhsus-GhELLspP-lTlpEAGlh-..............GQpLLLEEhsEMGNWPP	......................-.hpLC.sss..hsssloppFS+sDTIs.sIE+EhRclFsIssEcE.T..RL..WsKh.hsN.oa..E.LscsDsTlpDAu...Lhp................................................G.Q.lL....VIE.+NcDGTWP.........	0	23	31	57
+14688	PF14837	INTS5_N		Integrator complex subunit 5 N-terminus	Eberhardt R	re3	Jackhmmer:Q6P9B9	Family	This family of proteins represents the N-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing [1].	27.00	27.00	27.20	27.50	25.00	26.20	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.42	0.70	-4.92	17	78	2012-04-30 08:33:14	2012-04-30 09:33:14	1	5	69	0	57	82	0	214.30	46	23.26	NEW	tpslls-LptFlpsss...tp..shp......pLs+sALpLLcslPuuRsAVh-ahshlFccuVppahsshE...............t.ptstssss.-sslpElpssLpp.hlpssPpAWuslIssWulcLlGclus+hstRts.h.t...sls-hlphWhu.CpAh+pLlslhspClspllspss-sClssLLsouspHoPpFDWVVAHluosFPtsllo+lLssGlccFsst	....s.QpL.pElKsFlsulsshhupp.ssc......-hs+suLhLL+sLPsARsAVL-ahpsVF-EuVptalssl-.t..t................sscsssssssl--llpEVpplLpc.FlcsNP+AWAPlISsWS..l..........-LhGpLSSpYosR+t.hPpus.ulNElLQLWMu.CpATRoLM-lhspCLusLlsussDACV-ALLDTSVpHSPHFDWVVAHIGSsFPsTIIoRlLuCGLKDFss.p.	0	14	18	40
+14689	PF14838	INTS5_C		Integrator complex subunit 5 C-terminus	Eberhardt R	re3	Jackhmmer:Q6P9B9	Family	This family of proteins represents the C-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing [1].	27.00	27.00	28.70	27.30	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	696	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-13.19	0.70	-6.24	6	104	2012-04-30 08:33:54	2012-04-30 09:33:54	1	5	74	0	78	100	0	471.50	28	62.76	NEW	KlsSVVGILGHLAupHucsIRKtLLcMFptSLhst........ssshsus.pl++...ATVPFLLQLAuhSsTLLuAlSs-llchL+Pssl..Lsphtscapua.+p-h-shhsLsVHLl.psssGGA.+llphLlDTuossSslhstsssus.psl+EsCccLLQhLLh+LccLV+s+.............s..spsIPFL-ulpscluplssphLplccpRp.htpQLLsLLu.assPSlss-uhsaLLspApssEcLALhhpLhTp.ss.............shuGllshslcpsLupI......aspsls.p-htQLhpNLuphlp..aEcssphss....sh.uphlupAluuNLpshosLL.hps-sslucAhspLLuhhslPp.....sLSss.lLpLoRAsVpaFFhCLpppupstKs.........shpssspLLsRLsuh...SssupthsLppLlEsALa+usscLFGu..cpspcspppuhl........LL-pN++hsTolshstph.SVFHAGVIG+GhK.hhsspphs.-hVspNsppLlslIhpCCSssusss..............sp.ssIshEAsphVulhLVE.VsPDVhhstLsWPsEEauKsTlERDl+IRRpFcctPlLapLLclVAssRPALCYCSVLLRuLhATLlupWcoopc......ossS.hhLpsoshLVslMu.GQLLPPsLusl+-lhPpLsPFEVplLLhs.VWsYMR-NsP.PthFshsucpGhaaRDhoh-u..ssupYsssl+.VLp+NIcpL	......................................................................................................................................................................................................................................................................................................................................................................hh....u..ps..t.s.h.plht.......................................tp..h.p..................h...........hthh.Nl.hh.t...p.......................ht.th......l...h............hh........th.p.hspllt...hs........t....hL.ls...lphFF..hslp.ps..t...................tlL.c.sth...p..shhhsLp.llcsul...tt.thhGt....t......s.........................Ll..N.+......hstt..SVh.....HuGlI..G+......Gh+..............t...s.p.....p.t.hlphl.tCCts...t..t............................s..c..uhphlulhLV.E.l...ssD........s...h......stLsaP...sE-a...s+.s..ThERDltIt+tF.ppPlLatlLtllAtt.PA....LsYsSslLRuLhAshltpWcu...p..p...p......sst..ps....hh.soppLltlh.....u.upLlPPsLsphp.lh..htshElthlLhp.lWsah+...-psP..PthFh....stpu.hhhRshs.......tt......s..ahssl+.lhppplpp...........................................	0	26	33	57
+14690	PF14839	DOR		DOR family	Eberhardt R	re3	Jackhmmer:Q96A56	Family	This family of proteins regulate autophagy and gene transcription [1].	25.00	25.00	25.90	29.60	20.70	24.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.04	0.70	-4.59	12	132	2012-04-30 10:33:17	2012-04-30 11:33:17	1	3	62	0	75	135	0	175.90	37	79.55	NEW	ps-c--DtWllV-h.s....................................................................shsttssstpsP.....stsuhPss..........sh...................MEESWFVTPPPCFTAtG...ssstlEoSPhEsLLIEHPSMSVYsspssp.tsst..................cs...stsss.tsptppp...h.cps.spsAth.ss.puthLEpspphRtsQpspp+tE+ptLs+pslpRQNhsR-ppsRph+pp..ushlHQPs.Rp	...............................................p-.-.DtWhll-h.s................................................................................................................................h...s.sttss..........s.tshsss................ph........................M-ESWFlTPPsCFTAtG...ssh+lpoSPhEsLLIEHPSMSVYsstsohst.st..................................tsth....spt...c.p.psp.....hptp.t.......tthp.phsAsh.su.psshLcpspph....R....Qhh+p+sE+ptLs+pslpRQNhsR-pps+ps+pp..u.hhaQPs.p...................................................................................	0	11	18	37
+14691	PF14840	DNA_pol3_delt_C		Processivity clamp loader gamma complex DNA pol III C-term	Coggill P	pcc	CATH:1jr3_D_02	Family	This domain lies at the C-terminus of the delta subunit of the DNA polymerase III clamp loader gamma complex. Within the complex the several C-terminal domains, of gamma, delta and delta' form a helical scaffold, on which the rest of he subunits are hung. The gamma complex, an AAA+ ATPase, is the bacterial homologue of the eukaryotic replication factor C that loads the sliding clamp (beta, homologous to PCNA) onto DNA.	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.72	0.71	-4.01	3	1110	2012-04-30 11:55:48	2012-04-30 12:55:48	1	2	1105	10	199	712	93	123.50	45	36.20	NEW	PFHWVDALLuGKSKRALHILQQLRLEGCEPVILLRTLQRELLLLVsLKRQSAHTPLRoLFDKHRVWQNRRsLLo-ALsRLStTQLRQAVTLLTRsELTLKQDYGQsVWAELEoLSLLLCHKALAD	.............PF+WlDALLhGK..upRAh+ILpQL+hEG.sE...PVIL.LRTLQREL..hlL.ls...L......+....+.........p.....p..u..........p.....s..........P.........L.c..s.L..F.D.+.a..R..VW.Q.NR.R.s.hhspA..LpRLo..s...pLp...pAlp...lLs+hE...lplK....p.sa.upslWs.pLcsLSLhhCt.........................................	0	36	94	149
+14692	PF14841	FliG_M		FliG middle domain	Eberhardt R	re3	CATH:1lkv_X_01	Family	This is the middle domain of the flagellar rotor protein FliG [1-2].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.33	0.72	-3.97	335	2392	2012-10-02 13:19:07	2012-04-30 15:19:29	1	7	2070	8	564	1518	436	79.20	35	23.40	NEW	-spplsshlpsEHPQslAllLuaL.csspAAplLutLPp.....c.hps-lhhRlAphcsl....sPcslcclccsLccclsuhsspptsp	......-PpplAslIpsEHPQhIAlILuaL.csspAAclLuhhs-.....c.h+t-VhhRIAshssl....pPssl.pElsclLpppLsu.stpp..p...................................	0	185	361	455
+14693	PF14842	FliG_N		FliG N-terminal domain	Eberhardt R	re3	Jackhmmer:O66891	Family	This is the N-terminal domain of the flagellar rotor protein FliG [1].	25.00	25.00	25.80	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.03	0.72	-3.94	137	2340	2012-10-02 13:19:07	2012-04-30 16:08:09	1	5	2032	4	556	1742	439	106.20	30	31.40	NEW	ttppLoGtpKAAILLluLGc-tuuplh+c.LspcElpplotphuplpplsppphcsVlcEFhp..hhhupshlshGuhcas+plLpcuLGs-+Appllpclt.tshpspsh-	...........h..ppLoGh-KuAILLh.olGE-tAAcV.h.+H.LspcE.....lpplottMApl....pplsp...c...p...l...p...s...V...Lp.E....Fhp.....h.p...p...p..ss...ls......hs..ut..-Yh..+...plLh..+ALG..p-+Assll-clh.tstp.....p.....................................	0	183	356	449
+14694	PF14843	GF_recep_IV		Growth factor receptor domain IV	Eberhardt R	re3	CATH:1m6b_A_04	Domain	This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.16	0.71	-12.29	0.71	-4.54	30	1237	2012-10-02 14:20:19	2012-05-01 10:27:03	1	65	119	40	458	1185	9	117.10	34	13.30	NEW	lCsshCossGCWGPGPsQCLSC+sasRs..........spCVpsCshhpG.sREats.sppChpCHsEC...ttt...tTCsGPGsDpCscCsHap.......D..GsaCVpcCPpGl..utpt..laKYuDtsshCc.CH.NC.opGCsGPs.psCh	...............................Ccs.Cs....s.u..CaGsssspC.l.sC...p....p.....a..p...h..t..........................ppCl..spCs..h...........s...tt...h......tt....pppChtCHPcC.............poC.sGs....Gu....D.pC...........h..........p.C..t....p....hp...............................-....s.pCVsp.CPps.......................................pY..s..s........ps.hCp.Cp..sC.....t..s..Ctt.......s................................................	0	183	209	322
+14695	PF14844	PH_BEACH		PH domain associated with Beige/BEACH	Eberhardt R	re3	CATH:1t77_A_01	Domain	This PH domain is found in proteins containing the Beige/BEACH domain (Pfam:PF02138), it immediately precedes the Beige/BEACH domain [1].	27.50	27.50	27.70	27.60	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.17	0.72	-4.20	47	917	2012-10-04 00:02:25	2012-05-01 14:40:39	1	50	255	6	593	862	7	103.80	25	4.48	NEW	pllhohpsphlsPhsshpGplplossclhFhss..........................ttppthhs.stshphcW.hsplcpla.hRRYhL+coALElFhsDposhhhsF..sppsppclhpplh	.....................................................................................................s.hltsh..h..h.GhL................ls..pp..p..hY.h.ss........................................................................t.t.t......hst.s..pthstp.Whhscl+pla.pRRaLLp.ssALEl.Fh....s..............s......t.....p.....s...h....h.l..sF..spps+pclhptl.h..................	0	218	303	448
+14696	PF14845	Glycohydro_20b2		beta-acetyl hexosaminidase like	Coggill P	pcc	PF02838	Domain	\N	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-11.26	0.71	-3.48	183	633	2012-10-01 20:56:08	2012-05-01 14:42:21	1	14	263	35	389	763	42	125.00	26	22.32	NEW	lW..PtPpt..hph......uspshtlsstshpht.tss...ttt......................................................plLppAhp.Rah...................phlh...............................................s.t.tshh.........................................................................hpt.............................................................................tl...ppl.................p...........lpl...ps.t.t.........l....phssDES............Y.sLpl.................phs.......spIpApohaGAh+G.LEThoQL	...........................................................................lWPhPpp..hph......usthhh.l.s...thphp.tsss..........................................................sppllppAhp.Rhh..............phlh..............................................................t..t.hhshh.........................................................h..tstt.............................................................................................tl....ppl.................p..lpl........ss.s..ts...........h....phssDES............YsLsl.......................sps..t...tsplpAposaGAl+G.LEThSQL..........................................	0	139	213	310
+14697	PF14846	DUF4485		Domain of unknown function (DUF4485)	Eberhardt R	re3	Jackhmmer:Q8N8E3	Family	This family is found in eukaryotes, and is approximately 90 amino acids in length.	24.00	24.00	26.40	24.50	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.81	0.72	-4.27	27	127	2012-05-01 14:06:49	2012-05-01 15:06:49	1	7	65	0	79	139	0	82.30	36	12.52	NEW	pLDppFphhlthlcshltpLs.ct.-+hhsstWlpKLpps.....psht.+cpRNtYhthLlttlp.psplp.sPFsc.PPsGsL.slsphh	.......................................................LDtEFcphlhphcshlhpLspcp.-+ppsshWlcKLspss...tsshht++sRNhYuclLLchLp.cGhL-.uPFscpP.sG.sLtsLspa............	0	37	42	59
+14698	PF14847	Ras_bdg_2		Ras-binding domain of Byr2	Coggill P	pcc	CATH:1k8r_B_00, Pfam-B_3317 (release 26.0)	Domain	This domain is the binding/interacting region of several protein kinases, such as the Schizosaccharomyces pombe Byr2. Byr2 is a Ser/Thr-specific protein kinase acting as mediator of signals for sexual differentiation in S. pombe by initiating a MAPK module, which is a highly conserved element in eukaryotes. Byr2 is activated by interacting with Ras, which then translocates the molecule to the plasma membrane. Ras proteins are key elements in intracellular signaling and are involved in a variety of vital processes such as DNA transcription, growth control, and differentiation. They function like molecular switches cycling between GTP-bound 'on' and GDP-bound 'off' states [1].	27.00	27.00	28.90	27.40	26.60	25.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.31	0.72	-4.11	35	148	2012-10-03 10:59:06	2012-05-01 16:35:46	1	5	140	2	96	150	0	108.10	33	12.03	NEW	pslphIhpsGpo+tVNlssChsupplhc+sLKKhulpp............p.psashalhss......................t.ssssh+hLsDsELlsICpu..ssRsE+pRLIL...sppsc..Pstctlpputplhh	.......llplIhssGsTKsVNlpsCpsu--lhcpsL+Khshpp................pp.psYshaVLsu......................pssssss+hLsDsELhpICcu..scRsERsRLIL.Rplpts-...Pstcplpputtlh.h................	0	24	53	83
+14699	PF14848	HU-DNA_bdg		DNA-binding domain	Coggill P	pcc	JCSG_Target_393235 / GS13689A, Pfam-B_2593 (release 26.0)	Domain	\N	30.00	30.00	30.00	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.02	0.71	-4.40	21	175	2012-10-02 15:10:05	2012-05-01 17:10:52	1	2	71	0	39	179	1	122.40	23	58.18	NEW	hLKhhLh-NhlT.-spsDahu.pltsssolslc-Il-chhKc.sosl+pETltpslplhpchls-hlhsGhuVNTGlhpssssl+GVaps.sspass....p+poltlshssuspL.RpslucspVphhs.t	........................phhLhcNh.hs....-stsch.hu.ps..pt.ssslslc-lsccltpc.sosl.ppt..slhsllshhpcpht-hlhsGhsV...p...h...G...lhphslpl..p..G.s.h.s......sssa..ss....php..pl...tVsassupcL.+ctltphth.....h.......................	0	16	36	39
+14700	PF14849	YidC_periplas		YidC periplasmic domain	Eberhardt R	re3	Jackhmmer:P25714	Domain	This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins [1,2].	24.00	24.00	24.10	24.00	23.90	23.40	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.91	0.70	-4.50	388	2338	2012-10-02 23:57:29	2012-05-02 08:46:08	1	6	2296	4	565	1722	2667	274.10	26	49.21	NEW	plslcTchlp.hsI.s....spGGclschpL....t..pY..tsh...........ssps........s...hpL....lsssst........ahuphGhh..s.........s.t.ss......ps...t.apsss...s.....ht.hp..........sphs..ls.Lshsss.s.G.l.....php+sashc.s...s........Yhlslphplp.N.pustslss..p.as..plpps............tt.........t....h.h.....sa.pGssh.............p............h..pchsa.....s-h.p.........................hp....tt.st......Wluhhp+YFsoAh.......l....P.p.........ss...shhsp.hh........................hhth..sh...................h..s..shslssG.sstsh..ssplasGPK...........chchL....................p.......t.........................l................s..........pL-hslD......aG.Wh........halu+PlFhl	.......................................................................................................................lslcT-slc.lsI.sspG.GclpphhL....h..pY...pph........................sssp.....................s.......hpL...lpsssth......................Y.ApsG.Lssts........s.ss........spsh.asspt.......s.sh...l..ptp.................................................sphp....Vs.hoasss..s....G..h........phpKsashccs.....s.....................YhlsVshplp.......N..s....u.......spslph.....ssas...plpps.......s.t...................tss....hsh....oa.pGssh.ssp...........pphpKhpa....cclpc..........................................tp.phssp..sG..........Wl.Ahhp+YFsoAa.......I....P.p.......................ss..p.ssh.hsp.phs........s.....................hhth..uh...........................p...s.....shsltsG...psssh..supLasGPc............pctl....................t......s...........l....ss..........pL-.h.s.VD....Y..G..Wh........hFIupPlFhl.....................................................................................	0	177	356	464
+14701	PF14850	Pro_dh-DNA_bdg		DNA-binding domain of Proline dehydrogenase	Coggill P	pcc	CATH:1k87_A_02	Domain	This domain lies at the N-terminus of bifunctional proline-dehydrogenases and is found to bind DNA.	27.00	27.00	30.40	29.10	22.00	20.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.16	0.71	-3.89	114	1463	2012-05-02 13:07:34	2012-05-02 14:07:34	1	7	1420	13	300	1184	316	113.30	63	9.56	NEW	uhl-uhLpEYuLSocEGlALMCLAEALLRlPDstTtDtLIcDKlusucWppHlG.pS.sShhVNAuTWGLhlTG+llsss.....c..pt...shsusLppllpRhGEPlIRpAlppAM+lMGcQF	...hVpuLLpEFSLSSQEGVALMCLAEALLRIPDpATR...DALIRDKISsG..sWpSHlG...pS...sSLFV.NAATWGLlhTGKLVusp........s.....-ssLSpuL..sRlIuKuGEPlIRKGVchAMRlMGcQF.............	0	58	149	224
+14702	PF14851	FAM176		FAM176 family	Eberhardt R	re3	Jackhmmer:Q9H8M9	Family	Members of the FAM176 family regulate autophagy and apoptosis [1-2].	25.00	25.00	25.00	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.01	0.71	-4.53	13	190	2012-05-03 10:05:55	2012-05-03 11:05:55	1	8	53	0	110	149	0	132.10	37	48.52	NEW	-MsLLSNSlAAYAaI+sNPEphALYFVhGVChGLlLTLChLVlpISC...Rscs+t.psPc++ph+-ss..ss--ss-p--s-p--suDlcssc..............psph-tTL.ssNVFTSAEELERAQRLEERERIIREIWhNGQPDlh..GTtolGRha	..............h.ll.SN.LAuauaIp.spPEpsALYFVsGVChGLlLTLChL.VlRlSC....ppch+.....pts...p.cchh.tppp...psp.-ss....-..s.p.-t-.p.-.sss-.sh.t................pt.pts...shsVa.oShEthEhApRlEcREpIlpEIWhsut.Dh...hstshs.........................................	0	5	14	58
+14703	PF14852	Fis1_TPR_N		Fis1 N-terminal tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q9Y3D6	Domain	The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the N-terminal tetratricopeptide repeat [1-2]	25.00	25.00	25.00	25.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.27	0.72	-4.65	63	299	2012-10-11 20:01:04	2012-05-03 11:57:25	1	4	237	10	204	283	0	34.80	37	21.62	NEW	tpopFpYAWuLl+SpttpDh.pcGltlLpplh+sss	....popFpYAWuLl+SptpsD..pcGltlLp-lh+ps.......	0	51	100	164
+14704	PF14853	Fis1_TPR_C		Fis1 C-terminal tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q9Y3D6	Domain	The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat [1-2]	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.39	0.72	-4.08	60	363	2012-10-11 20:01:04	2012-05-03 11:58:45	1	12	284	10	239	400	24	52.10	39	30.22	NEW	R-tLYYLAlGpa+lt-YscA++alctLLchEPsNpQAtsLcphI-c+lp+.-GL	............R-hLYYLAlGp.Y+LscYscAc+Ys-tLLch.EPsN...pQAtsLcphI-cclpK-Gl...........	0	73	128	198
+14705	PF14854	LURAP		Leucine rich adaptor protein 	Eberhardt R	re3	Jackhmmer:Q96LR2	Family	This family of proteins activate the canonical NF-kappa-B pathway, promote proinflammatory cytokine production and promote the antigen presenting and priming functions of dendritic cells [1].	25.00	25.00	25.10	25.00	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.66	0.71	-4.40	7	138	2012-05-03 13:55:31	2012-05-03 14:55:31	1	3	62	0	88	131	0	103.30	40	36.75	NEW	psstsussppssspushctL-sKlhhL+.EMAaLRAlDVKlhQQLlslNEGIEulKWlhEE+uslTSRsSSLouS.YSLstup.soShRGSasSLpDss..DcLDuISlGSYLDTLA.D-lsE.s	...............tss...........ts.s.hpsL-splthLRpE.MssLRulDl+LLpQLhslNESIEul+WhlEE+usloSpsSSLouS.h.SLhtup..tpp.cGShs.......................................p...........................	0	12	18	43
+14706	PF14855	PapJ		Pilus-assembly fibrillin subunit, chaperone	Coggill P	pcc	Pfam-B_9717 (release 26.0)	Domain	PapJ is part of the Pap pilus assembly complex that plays an auxiliary role by ensuring the proper integration of PapA into the fimbrial shaft. PapA is the major shaft protein of the pilus.	25.00	25.00	50.30	50.10	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.10	0.71	-4.82	3	54	2012-05-03 16:50:17	2012-05-03 17:50:17	1	1	37	0	1	26	0	178.40	63	99.69	NEW	M..NRTTsGLYLAALLlSuSMsoVLQA-ELllRDDFFVADEsRHQWVNE+NGRTGoLNVKGALVSSPCIL-TPEVsLPLpcDNG+YV....LNLKLS+CGDGtS-lPE+cussphNlsVKQSlVLKcGcsslLLS-+KsuGpsRcll+cGDNQLlYhlN+cQYEKIAcsQpcsTt+.chSDu+os..sL+LsIhYE	MVV.NKTTAVLYLIALSLSGFIHTFLRAEERGIYDDVFTADE.+HYRINE+GGRTGoLsVSGALLSSPCTLsoNEVsLSLR.-N+....shu....LhL+LuGCGDGGAl.Pu+cuss...MsVsuSlVhusGpsusLLP-+KhuGscHhVl+DGDs.Llhhss+cQp-hLAuhppcsTtc.tcYSD..u+os..hLRLsIcYE............	0	0	0	0
+14707	PF14856	Hce2	Ecp2;	Pathogen effector; putative necrosis-inducing factor	Stergiopoulos I, Coggill P	pcc	[1]	Family	The domain corresponds to the mature part of the Ecp2 effector protein from the tomato pathogen Cladopsorium fulvum. Effectors are low molecular weight proteins that are secreted by bacteria, oomycetes and fungi to manipulate their hosts and adapt to their environment. Ecp2 is a 165 amino acid secreted protein that was originally identified as a virulence factor in C. fulvum, since disruption reduces virulence of the fungus on tomato plants. We have recently determined that Ecp2 is a member of a novel, widely distributed and highly diversified within the fungal kingdom multigene superfamily, which we have designated Hce2, for Homologs of C. fulvum Ecp2 effector. Although Ecp2 is present in most organisms as a small secreted protein, the mature part of this protein can be found fused to other protein domains, including the fungal Glycoside Hydrolase family 18, Glyco_hydro_18 Pfam:PF00704 and other, unknown, protein domains. The intrinsic function of Ecp2 remains unknown but it is postulated by [3] that it is a necrosis-inducing factor in plants that serves pathogenicity on the host.	25.00	25.00	25.60	25.10	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.54	0.72	-4.08	39	124	2012-05-04 15:03:41	2012-05-04 16:03:41	1	6	44	0	97	117	0	102.60	27	20.68	NEW	spCss.So.ap.spTss.sSP..hssDCtplhpslt..ps.....G....p.W..s..lt.....s.tsp.........+plsphGoCsFGlps......h.p..ush...th.t...lGspDlhDllps..uIs..pau......ps......G+..VGApGphpC	................Css..oo..ah..spTos..uSP...hssDCttlhpslt..ss...........G....p.Wpht...........s..ssp...............pplsphG.....oCsFGlps................tp...ssh.....th.tlGspDlhcllpp..ulp..pas................ts.......G+..VGupGphpC....................	0	17	47	73
+14708	PF14857	TMEM151		TMEM151 family	Eberhardt R	re3	Jackhmmer:Q8N4L1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 338 and 558 amino acids in length.	27.00	27.00	28.90	33.20	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.62	0.70	-5.88	9	144	2012-05-08 07:39:01	2012-05-08 08:39:01	1	4	59	0	100	128	0	347.60	50	78.89	NEW	QRPlKQSLotSLCRESHWKCLLLSLLMYuChGsluWCpLspVT+Luhss.......u.....apGpS..hlYH......DSPCSsGYlYIPLAFLsMLYlVYLVECWHCas+sphthKs-lsoVhERlpRhQQAsPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHsAcuEFDYupCGVKDVSKpLhGL-sassTRLRFTKCFSFAsscuEsuYLTQRARFFs-NEGLDDYMEAREGMHLKNVDF+EahlAFsDPs+.PWYspphsFWhAuhhhLSWPLRVlsEYRTAaVHYHVEKLFG.......h-hs........u.oPss....sshtttlsRVsTlDoTELEWHIRoNQQ.LVPSYSEAlLMshuptsstsstos..........................psYut...........hhpsC-RCpR..........osSSSSl..................hSRsuht.s..s....ssRLu........husS+FSLGRlaGSRpo..sLaRSRS	.............................................................................................QRPlp.ShstSLCRESH.WKCLLLoLLhauC.huslsWCplspVs+Lshss...............u..ht.Gps..hh.Y.......sSP.CSsGYlYIPLAFlhhLYllYLs..ECWHC.psRppht.h+s.DspoVhphlpRhQQAsPCIWWKAlSYHYVRRTRQVTRY..RNGDAYTTT..QVYHERVNTHsAcuEFDY.....uppG.V+DVS.....K.p......LlGLptt..ssTRLRFTKCFS....FussEuEsuYLsQRARFFs-N.......EGLDDYMEAREGM+LK.s.V.DF+E..hls.as.DPtp..PW.YspthsFWhsuhhhLSWPLRVlscYpTAasHYpVEKLFG.....................................................s.ssst.......s.t..l....sRVsTlD..T.E...LEWH....Ip..sNpQ.lVPSY..SEAhlMshst........................................................h..h..p..ssppC.....p+..........s.opsuh.....................tt.t.....................................................................................................................	0	23	34	67
+14709	PF14858	DUF4486		Domain of unknown function (DUF4486)	Eberhardt R	re3	Jackhmmer:Q96N23	Family	This domain family is found in eukaryotes, and is typically between 542 and 565 amino acids in length.	25.00	25.00	25.50	25.50	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.84	0.70	-6.25	5	92	2012-05-08 08:35:29	2012-05-08 09:35:29	1	4	58	0	60	81	1	326.70	35	26.02	NEW	pcaEh+RRGAsTLFNIWsKYcPRLPssYYNEKLLKVGDSLsQIK.................EYKLALhQCYGRYLQQFso.NsDEspsD..lspFKssFFPcGFcDcTAtLTFHALpG+NlCsYQLVC-SDsNLQNcESVppCL+ILSSLRLIMQAALPQEsLCWIIFNGTlHIYoICR+LMsIGQSSKVLEYLLWASMCMESSVPLLSlRYLTWRATLYsAVCQCYYDC+AGIHGEuFARRALuKINEL+QLEpMSSScuopEop+hFREATIKMAVMIFKRuVFESRRKPKulFRPKlRlNLKEsQsLPWPRTsTERLLsEhFDGTASQFLAVLEALSDSNRRlLQTGP.VoD.EsEI+DVVSELFhAGhE.L...LIhuNl+ss.............upLDFPpoSLLEpllsc+NsISV-AAVKFlKLAFoYEEWulF-SLustLlpFLQpQ-DPpuKKAEK-LcLLtAlEPLlss+Rs+.Ghhlsp-s-K-uQospsaLKHhss+psphhssta....oEDlFpLAsTLHsCVCsssQsI..pPDKDIVlDllhFLWQKCKlGlQRlsIs+h-ssKYspKhu	.............................................................................................hl.hu-.h....t...........................................................................h....h..hpsh.....s.hth.htts..h.p...sh..hh....p....hLt.....hRhhhphsl.s.t.-.....phhWllaNGolhlYplCcpLh..hh..G......oscslthl.hh.s..hshE........l.L.s.+YL.WRhpLhshlstsh.c.....t.h...pu.hhAp+ul.+lp-L.pLE.hs......t.tt.hh.s................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..........................................................	0	23	31	41
+14710	PF14859	Colicin_M		Colicin M	Eberhardt R	re3	Jackhmmer:P05820	Family	Colicin M is a toxin produced by, and active against, Escherichia coli. It catalyses the hydrolysis of lipid I and lipid II peptidoglycan intermediates, therefore inhibiting peptidoglycan biosynthesis and leading to lysis of the bacterial cells [1].	27.00	27.00	32.20	38.40	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.77	0.70	-5.51	2	47	2012-05-08 11:57:22	2012-05-08 12:57:22	1	2	30	16	4	47	0	223.20	56	87.11	NEW	phpl....PuT.l.s.t.Gs.p.ou.pVPusGsllsphV......Yuhhp.ssMh.ptLpthcs.h.taGhss.....hI.sslthhpsADh.LlhpPtlSshDAap..hpcsu..Q.shp.hs.pphSGsshTPhhAltHaLhGNGsptSVpIupIGlp.oP.KIsplhsIIpouhlGphsVshphoahTGp.sVIsthYLGsITLphpGplThsssGohoasGVV+uasD+YDhNASoHRsshsEuhT....clGthhsuK-YtI.lsGEl.I..ShtR	.....................................................................s.....................................................MslpsLptlcDalcpHGhss.....hI.sslthhpsADh.LlhpPtlSshDAap..htcsu..p.shpphsh+phSGNVhTPIsALAHYLaGNGA-RSVNIuNIGLKISPhKIsQIpDIIcS..Gs.V..GTFPV...Soc..Fo...+AT.....Gc...hsVI...o...uuYLGNITL+TcGTLTISAsGoWTYsGVVRSYDDKYDFNASTHRGlIGESLT....RLGAMFS.GKEYQIllPGEIcIp.SGKR................	0	0	0	2
+14711	PF14860	DrrA_P4M		DrrA phosphatidylinositol 4-phosphate binding domain	Eberhardt R	re3	Jackhmmer:Q29ST3	Domain	This domain binds to phosphatidylinositol 4-phosphate. It is found in Legionella pneumophila DrrA, a protein involved in the redirection of endoplasmic reticulum-derived vesicles to the Legionella-containing vacuoles [1,2].	27.00	27.00	49.40	49.30	25.80	18.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.55	0.71	-4.36	3	23	2012-05-09 07:41:44	2012-05-09 08:41:44	1	1	8	9	3	20	0	112.70	42	28.65	NEW	cNLcEsl..KhupccKhtuRpHcaTA...s+psspshKE+YpQlKGDuLK+sILs-LKDcLAEIcsh-sLK-hltEFKuSsEYpILAKGQGLTTKlLGLKTSSp+uVEcIFcEAcEcIpSscp	............pshc.sl..c...stKhtuR.Hhass...s+hhs.phpEpYptlKGDhLK+sILp-LKssLtcIssh-pLc-hhtEFKsSsEYpILucGQGLhT+shsLKTSSh+ulpchhcEscccIpsp.....	0	3	3	3
+14712	PF14861	Antimicrobial21		Plant antimicrobial peptide	Eberhardt R	re3	Jackhmmer:P86698	Domain	This family includes plant antimicrobial peptides [1-2]. They adopt an alpha-helical hairpin fold stabilised by two disulphide bonds [2].	27.00	27.00	36.50	30.10	24.90	21.20	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.86	0.72	-4.47	22	86	2012-05-09 09:58:20	2012-05-09 10:58:20	1	7	8	0	22	72	0	31.30	45	52.48	NEW	spspccCc+pC.pHHp..D.hc+QpClpcCcp+c	..scupccCR+pC.pHH+..D.W++QpChp-C+p++.	0	0	8	15
+14713	PF14862	Defensin_big		Big defensin	Eberhardt R	re3	Jackhmmer:Q0H293	Family	Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure [1,2].	25.00	25.00	25.00	25.00	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.97	0.72	-3.91	4	41	2012-10-01 20:50:19	2012-05-09 13:58:57	1	1	10	2	2	47	0	78.80	58	67.17	NEW	AIPllYhGAsVuPsVWsWLVshhGAAAVsAAulp.......puSsDsHSCAsNRGWCRSpC..FpHEYlDsapSuVCGpYcCCRs	.................Ll..PlA.YAGhTVSsPVFAALVusYGsYAVhRYsIR....................pusp..DSHSCANNRGWCRsoC..FSHEYpDWaN.ssVCGSYcCCRP.............	0	1	1	2
+14714	PF14863	Alkyl_sulf_dimr		Alkyl sulfatase dimerisation	Eberhardt R	re3	Jackhmmer:Q9I5I9	Domain	This domain is found in alkyl sulfatases such as the Pseudomonas aeruginosa SDS hydrolase (Swiss:Q9I5I9), where it acts as a dimerisation domain [1]	26.00	26.00	26.00	26.80	25.90	24.80	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.37	0.71	-3.95	196	988	2012-10-11 20:01:04	2012-05-10 11:46:15	1	8	790	10	240	798	507	139.00	47	22.62	NEW	hTssEIA.-plp.LPssLsp.paasRuYYGolsHNs+AlYptYhG.WaDGNPAsLpsLsPt-pAc+YVchh..GGs-pllppAcp...saspG-..........YRWuAplls+lVa.............A-PsNp.p.........ARpLhAc........sh-QLGYpuEsusWRNhYLoGAhELRsGs	........................hThsEIu-hl+..LPsuLsp.sWtsRGYYGSlSHNs+AVYphYLG.aaDGN.P.AsLpPhsss-huc+YVphh..GGu...spVlphApc...uhcpG-..........YRW....uAcllcpllh.............AsP.ssp.s.........A+sLpAs........shEQLGYQAESu.sWRsaYLoGApELRpG.l........................................	0	55	123	185
+14715	PF14864	Alkyl_sulf_C		Alkyl sulfatase C-terminal	Eberhardt R	re3	Jackhmmer:Q9I5I9	Domain	This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.44	0.71	-4.14	140	895	2012-10-02 14:08:01	2012-05-10 11:49:45	1	6	760	10	211	992	282	122.00	34	19.64	NEW	sssos-hltshssc.hhDhlAl+lsus+At.......st.clslshhhs.....Dh.s.....c...........patlplpNuVLst....hpstp.......ssA-sTlol.s+ssLhslh.hstsshsphhtsspl...pl.pGDtstlppLhuhLDph-.....stFsIVsP	.....................................................s.suSsDslpuMos-hlFDahu..VRL..s.usKAs..........Gp..slslNashs.....-...s.....-................shpLpLpN.uVLsa........pcshp.......spADsoltl.sRpsLpsll..h....G...psphsphlp.u...tcs..+l...tG.ssstLpclluhLDsFD.....hhFNIVTP...............................	0	53	111	163
+14716	PF14865	Macin		Macin	Eberhardt R	re3	Jackhmmer:B3RFR8	Domain	The macins are antimicrobial proteins [1-3]. They form a disulphide-stabilised alpha-beta motif [3].	27.00	27.00	28.00	34.10	25.00	18.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.69	0.72	-3.87	6	15	2012-05-10 12:11:02	2012-05-10 13:11:02	1	1	8	2	2	17	0	57.30	45	63.35	NEW	sCa-sWSRCoshoSthTGlLW+oCs-pCK.cLG+psGpCh.sPS.sCP..sch.pshQCpCa	sCa-sWSRCothoushTGILWcoCssRCK.ChG+ssGsChpsPS.sCsh.pc..csaQCpCh....	0	2	2	2
+14717	PF14866	Toxin_38		Potassium channel toxin	Eberhardt R	re3	Jackhmmer:Q9NJC6	Family	This family includes scorpion potassium channel toxins [1-2].	27.00	27.00	27.00	27.00	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.51	0.72	-3.88	13	40	2012-10-01 23:31:40	2012-05-11 08:49:57	1	1	17	0	0	57	0	56.80	41	66.59	NEW	splKstLpplhcKlht....l.upSpaGCPs...I-paC-DHCps.c+t.GpC-shcCpChp..u	.................s.pl+phlpsVlHKl........uKopauCPs...hpsaC-cHCps.c+ccGhCHG...h...K..CKCsh..s...	0	0	0	0
+14718	PF14867	Lantibiotic_a		Lantibiotic alpha	Eberhardt R	re3	Jackhmmer:P86475	Family	Lantibiotics are two-component lanthionine-containing peptide antibiotics active on Gram-positive bacteria [1-2].	27.00	27.00	37.50	36.90	25.20	24.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.73	0.72	-4.70	14	26	2012-05-11 09:53:12	2012-05-11 10:53:12	1	1	26	1	4	22	0	31.70	45	48.22	NEW	ssssssshslShsLGNcGthCThThEC.ssCp	.h.sshsphhhlSpsLGNcGtlCThThEC.ssCp.	0	2	2	4
+14719	PF14868	DUF4487		Domain of unknown function (DUF4487)	Eberhardt R	re3	Jackhmmer:Q9NSG2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.	25.00	25.00	31.00	25.90	21.80	23.80	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.86	0.70	-5.80	12	134	2012-05-14 11:54:13	2012-05-14 12:54:13	1	2	71	0	67	136	0	387.30	29	64.66	NEW	hslhssoWKhlIp....pt+sslcsplphp...-IlssLhpslh.Sh+sshp.........hhpsshp-...shshp.hp+shh.s+FahsslV+hspta.s.h.tsspplhpLhl.l.hSpFh.uLpttplscstpE.luphh.hshssLlspLLsts.....hhpphhtphLs.......hssc..p.....hsp.shhhh.s.hD+lso.s.plhslassss...tphpcl.lhp..slFtshhpsSsElp.sspLt..............................Gs.upupt..lh.olYptlhhpLpsah..ss.hsss.tascLEthLLpslLpsphlst.lsh-lWCFlu.Rausu-LssphlshlspLlKsh........P........usshphhs..LshL..LpR....hhh.hssphpsphlpphpsp...psps..........hhlhcthsL..puLssp....l+p...pstcplhsshhu.hhppa.p..........sosohGtlt..stsLSusLtsppsussslDt+plsslltllsphhshl..cpltsc..h.pphhshhLslluhh.hphhpsphlppllptL.psLhhppsssp......l+hs...hhpFluuLGch.hsps.psthsstl.....pLaphLLp-cpWhlhphAlpAFshFApcTspppl	........................................................................................hhhp..........h.....h.....h....h......h....................tt......t.t.h.hhhh.h+ahh..hhph.t.a...s.h.t.h.tp.htLhl.h.tS...tF..SL.ttphsKutpE.hsshh.hshssLlstL.Lsht.....hhp.lh.sh.L-........h.sE..p....hs...hh.h...hDphspts...h.slhshss...pptspl.Lhp..hlF.sh.phSsELp.sspLt..............................t..sputt..h..shaptlh.tLpshh..h...h.ss.ha.tl-hhLLpshht..p..s..l..-hWsFhh.+..............hup.phs....hh..lh..lht.h........s...............t......h.......ht.h..ltp....h....h.................................hht..........................h..h....t.h........t........th..................................h.........................................................................................................................................................................................................................................	0	18	30	46
+14720	PF14869	DUF4488		Domain of unknown function (DUF4488)	Coggill P	pcc	Pfam_7936 (release 26.0)	Family	In most members this family covers almost the whole sequence, but a few member-sequences also carry a TonB_C domain, PF03544.	25.10	25.10	25.10	36.00	24.70	23.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.68	0.71	-4.59	11	63	2012-05-15 08:09:31	2012-05-15 09:09:31	1	4	49	0	9	41	0	130.40	55	67.57	NEW	psLpGVWQhCh.hspss-lsucLcsuss.LKlLS-DspFhNlhh...hs.suAIIhupGpYch.SDs.......sYsEplEK.slaLshlsGp-N.lphEhhc.....DsLhhl+ahlsschs....spWhpEhW+RV..PshhP.s...hsc	.....u.sLcGIWQLCaYVS-sP-lPGtLKPSNo.FKVLSDDGphlNhTh...hPsus.AIITGYGTYcQhoDs.......oYpEsIEK.NIHLPhLcspDNlLcFEht-.....ssll+LKYFlcsDhNGNElNsWaaETWKRVpMPshaPcDlVR......	0	2	8	9
+14721	PF14870	PSII_BNR	PSII_YCF48;	Photosynthesis system II assembly factor YCF48	Coggill P	pcc	Pfam-B_547 (release 26.0)	Domain	YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localised within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII [1]. YCF48 is found predominantly in the thykaloid membrane [2]. It is a BNR repeat protein.	27.00	26.00	27.00	26.00	26.90	25.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-12.09	0.70	-5.43	23	762	2012-10-02 00:45:24	2012-05-15 10:59:18	1	27	377	1	329	819	370	140.60	23	53.77	NEW	hsshsssPWchlpLso-s..slLDluFs..sspHGaLVGoptolLETsDGGcoWctRs...LDls--.saRhpSVSFsGsEGWIlGcPulLLHTsDGGcoWoRlsLSsKLPGsPhhIsALGss.sAEMsTss...GAIYcTpDuGpsWcAtVpEsl...................GslRslpRus-GcYlAVSSRGNFYuTWpPGQshWpPHsRsSSRRlQsMGFs.c...GpLWhlsRGGplpFos....sss.-sWsc..........shhPlhosGaGlLDLAa+ss.s-lWsuGGuGoLlsSpDGGcoWp+Dpss-slPoNhY+IhFhss.....spGFlLGpcGlLLRYs	.................................................s.....................h..pt......lhs.lhFh..stp..pGas.......V....G...p.........t.......u.....h...l.....LpTs.DGGpoWp..ttt................s....h....t...p................................h......s..l...t....h......s.p..p.....s..a..h.....s.......G.........p.........u....h........lh+..op.D.sGtsWpt........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	128	201	276
+14722	PF14871	GHL6		Hypothetical glycosyl hydrolase 6	Coggill P	pcc	Naumoff D [3]	Family	GHL6 is a family of hypothetical glycoside hydrolases.	35.00	35.00	35.10	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.66	0.71	-4.13	13	111	2012-10-03 05:44:19	2012-05-15 14:59:04	1	3	70	0	59	240	54	134.20	26	19.46	NEW	Dscphscth+ch+usolslFupstaG.hsaYsop.l....ts..c..HPtL..p.t....DlLtEtlcAs+ccGl+Vslhhshs.hccplhppHP-WthhstsGt.........stthstst.a.p...lChNSsYh..-.ahttpl.cEslc...th..slDGlFhDh	............................................................tphhphlcpuplsulsl.upsttG.huYYPoc..l...............tp..h.......pPtL.....p..p.....................Dllu-hlcAs+ctGl+lhs..h.h........sh.....s.....h....-...p......p..............h.h.........c.pHP-Wh...hh....stsGp...................tphhpss...aht..........hCh.N.u.s.Yh..-..alhppl.cEllp...pY...ssDGlFhDh...........................................................	0	36	52	54
+14723	PF14872	GHL5		Hypothetical glycoside hydrolase 5	Coggill P	pcc	Naumoff D [3]	Family	GHL5 is a family of hypothetical glycoside hydrolases.	23.70	23.70	26.50	24.60	22.80	22.20	hmmbuild  -o /dev/null HMM SEED	811	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.45	0.70	-6.77	10	27	2012-10-03 05:44:19	2012-05-15 15:19:15	1	1	22	0	6	24	9	739.50	52	96.71	NEW	ppLL-WAssI-p.S-sThFEKAQplAsRLGAHYRs.DGLTEIGFWTPELuu-lIQs.+sIaLEVFTPl-sIDhpts-QslpF+RDplpLc+QGEYtWGVVuGL+AGTR-QhGSFYWLRYlD.p.sclpsIRDsLAYSLPYGVFAPAELYDhcsLQccRADLsYFcppuup.............p..s.....sss..........lsRVPAPpNILQLHVsTASPsGTLuGLTclYQRIucKLusupPLTPAEpNYlGYDAVQLLPIEPTlEYR.sE.pss.cHcFFslcs.........c-.sphss.s..l..pstcl.....clsL+KP-TQNWGYDVsIlGSuATNPAlLpTLRPDElVDFIATLHNFsTGPIQlIYDLVYGHADNQul-LLNspFLKGPNMYGQDlNHQsPsVRAILLEMQRRKlNTGADGIRIDGGQDF+FFNPLoGcVEYDDsYLLAMuDlVQ-IGstpRhLFTIFEDGRPWPsEGWEEISTYRDLIEL+P-SFQWGPLIFAHNTPsLpGFWD+KWRRVCEVMhpG-+WITGCGNHDTVRRGNQlssst.sINWpLGsTLPEVLpNAYDNPAlsLWVYGFuPGLPMDFINusMRAPWGFFRNTDDRYGVKVVAEEh.GFLDWQloPElYppsp.lFs+LKpLGFo-L-tLRQFh+ALppAht-oDYDL-cVAphCQpslGssst.p-.............Lpclshs-tssFLssLDVuKLKpFAhAFMEDsH-hCNVp+apDpl-ssQsuFNLALRcFR+u+PWL+cNLs..s.s.DRFN+Io-cppTlFYGlRssPh-t-......sptpspplAMVAHMGGEPhTVsLG-WLpLDLscWplAIASPGLc....l....c...D....L+u..FEL+DSQulLLE	.............................t.pLhsWAtslpp.SstshFptApplAp+LGAHaps.DGLTplGFWTPcLsup.hhpp.tpIaLEVaTPhptIDhpusp.QslhF+R-hlpLtppGEahWuVluGh+sGoR-phGSFYWLRYhD.t.sphphItDPLuYSLPYGVFAPAElYDlcphQtpRsDhsYhcppss......................................p.........t...............ls+lssPtNILQlHlsTAospGTLsGLTclYpRlucKlhpt.sLoPsEpNYlGYDAlQLLPlEPTlEYR.hc..p..tptFFshts.........c-...............tpl.....plpLpKPcTQNWGYDlsIh....GSuATNPulLtThRPDElVDhIATLHNFPsGPIplIYDlVYGHA...DNQu.hpLLNtpahK....GP..N..MYGQDLNHQ.PhVRAILLEMQRRKh.NoGsDGIRlD..GuQDF+aFNPloscVE.DDsYLhtMuDlVQ-IusscRhhFsIFEDGRPWPp-GWE-hSTYR-LI-hc....P-uaQWGPLIFAHNTPsLpuFWp+KWcRVCEVhhpG-pWITGCuNHDTlRRGsQls.p.....t.pINhpLGsTLsEVLpNAYDNPAstLhsYGFsPGLPMDFlNAhh+APWGFhRNTD-RYGVKVsuEEs.GFLDWQlsPEhYptst.hFspLKtLGFpcLt.LppFhcuLtpAhhpsDYsLptlAchCptshs.pst.pt.............hpphthsp.sthlppLsVsKLKpFAcAFMEDsHEhCsVSpat-pl-stpssaNLtLRpaR+s+PWL+cNLt..ss.D+.Fs.pIps.sspTlFYGlRssP.ptc......s...stpVshVsHM.tG.-PhpVslGDWLpLDl..s..cWplAIAoPGlp....l....-...s....Lps..FEL+DuQullL..............	0	1	5	6
+14724	PF14873	BNR_assoc_N		N-terminal domain of BNR-repeat neuraminidase	Coggill P	pcc	Pfam-B_13890 (release 26.0)	Domain	This domain is usually found at the N-terminus of the BNR-repeat neuraminidase protein family.	25.00	25.00	25.60	25.80	22.30	23.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.24	0.71	-4.41	37	147	2012-05-15 14:59:52	2012-05-15 15:59:52	1	11	89	0	21	137	9	139.20	24	23.46	NEW	tus-s....lhlcpsplPlLlc+psNslhhlRlpsppspt...LsclsLshstsssLsDIpul+LYhuGo.cuhpcps+thhtPlshh..........................spplsLp.....us.pLh.sGsNaFWlSlphK.sssoLts+lssphsplphsspph	......................tp.....lhlcpsplP.lL.lc+psNslhtl+lpsppsps...LsclsLshstssslsDIpulcLYhuGs..cuhpsps....+hhhss.lsh...........................spplsLp.....sp.pLh.sGsNaFWlolph+.ssssLts+lssslsplphsspt.h..............	0	6	16	21
+14725	PF14874	PapD-like		Flagellar-associated PapD-like	Coggill P	pcc	Pfam-B_1987 (release 26.0)	Domain	This domain is a putative PapD periplasmic pilus chaperone protein family.	27.00	9.40	27.00	9.40	26.90	9.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.40	0.72	-4.07	5	621	2012-05-15 15:06:52	2012-05-15 16:06:52	1	29	105	0	426	554	6	86.70	17	7.00	NEW	sPpLEVpPspVcFGpVlPGpRYltTVcLTNsSTVPCRYRVRlssss+shLpVpYs+QFVAPGLTscscVELsGoQPhGsMcupLsVsHEGGsl-VsVchcTs	..............h...hplps.s.plcFG..slh.hsp........s.h.s.p.s..lpLpNsu..hl..s..s..pa.c...l........p......h...s..p............t....t.....h.....h...ph........................s.......lss.t..p........h........l.h......................................................................................hhh...................................................................	0	201	249	315
+14726	PF14875	PIP49_N		N-term cysteine-rich ER, FAM69	Coggill P	pcc	manual	Domain	The FAM69 family of cysteine-rich type II transmembrane proteins localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases [1]. It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished).	21.00	21.00	21.00	21.00	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.23	0.71	-4.57	15	182	2012-05-16 11:38:45	2012-05-16 12:38:45	1	5	71	0	108	161	0	138.70	34	35.20	NEW	uRLshh+hKYLlhsWlullluSWVlYhpYs..oYoELCRGpsCchhI...C-+Y+pGlloGSsCpsLCspcolh.ht+C......lSsssspQl.....aouhWp-p.llIKCthpcsh+tchs.p.hs+p-hshacpPT+GTShpEF+EMV+salKsKlG-QssLssLlspllsl	.........................................Rhshh+h.hhhhshlslhl.ushl.hhhtYs...saoEhCpsc.s.+hhl..............C-cY+pGhlsGshCpsLCspcslh.at+C......Lss.pssppl.....atuh.Wps.p...sllKsthcpshc.s.htsp....scc-hs.h..h-tP....ohpcF+EMlhshhKspLG.phs...sthls.ll..h....................................................	1	21	29	61
+14727	PF14876	RSF	RSF1P;	Respiratory growth transcriptional regulator	Wood V, Coggill P	pcc	Pfam-B_36578 (release 26.0)	Family	This is a family of transcriptional regulators that determine the transition from fermentative activity to growth on glycerol [1].	27.00	27.00	35.70	34.80	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.26	0.70	-5.66	5	29	2012-05-17 09:46:49	2012-05-17 10:46:49	1	1	16	0	8	23	0	327.70	73	82.81	NEW	MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMETPRTLNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAVQRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPKRRDIKGNHLSKLLFAKSPLTINTYCQFYDRRTKRICNQEMIWKDKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQSKIAMNDLIEILIDLNIPFSVLDYQPMRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNNSNSGTPHNHNQNQH	.............................................MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMET.RhLNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAV...QRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPK..RRDIK...G.NHLSKLLFAKSPLTINTYCQFYDRRT....KR.ICNQEMIWK..DKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQScIAMNDLIEILIDLNIPFSVLDYQPhRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNN..SN..SGTPHNHNQNQH................................	0	1	4	6
+14728	PF14877	mIF3		Mitochondrial translation initiation factor	Wood V, Coggill P	pcc	Pfam-B_22619 (release 26.0)	Family	This is a family of mitochondrial initiation factors IF3.	31.10	31.10	32.80	62.20	30.30	29.60	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.06	0.71	-4.91	14	37	2012-05-17 10:23:41	2012-05-17 11:23:41	1	1	36	0	26	37	0	177.60	35	49.66	NEW	+KslphcasoGS-+AppAhpsllsclathsppspl+hlsspssclEppslhchspslDLscpGlthVssp...pspt...plPLVKhVcsppAlKpYSDcLAppKEcELlphG..hs.+phtp+.cs-+ccsshKhl+lSWpISssDLspQKspEItspL...cKGp+lhl.alscKsshsss..stsc-p	.......+.hhhpasoGo-+A+pAhpsllsclaphsp.ptplchlsssssplcpsslpphspslDLscpGLplVshc..................pssptp.plPLVKllcs+.hlKpYSDhLAppKEpELhphG...sh+phtpphps-+Kc.sshKpIplSWpIsssDLppQKspEIhphL....cKGp.+lhl.alssKpshsss.........................	0	3	14	25
+14729	PF14878	DLD		Death-like domain of SPT6	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	This DLD domain maintains the characteristic overall topology of death domains, as it consists of a six-helix bundle with three stacked antiparallel helices and an additional helix inserted between the final two helices of the bundle. Although it is unlikely that the Spt6 DLD functions in an apoptotic process in yeast, its prominent location and the observation that it displays the most highly conserved region of the Spt6 surface suggest that it mediates important intermolecular interactions [1,2].	35.00	35.00	38.40	38.40	31.60	32.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.53	0.71	-3.98	4	271	2012-05-17 11:48:29	2012-05-17 12:48:29	1	35	233	2	208	285	1	113.10	46	7.70	NEW	h-lLDuoRlHPEsYEhARKMAsDALEYDEs..AEctsstGslpElLE.......pst+Lc-LsL-uaAEELERpsatcKt.TL.cIRhELpstYc-LRssa+s.ss-EIFpMLTtEoPET	....-hLDsTRlHPEsY...-hARKMAsD...AL.E..hD........E-........t.p..-...p..s...s...sG....A.l.cc.l.l.c..........................s.s.-.+Lc-Ls..L-taA-pL...E+p....thtcK.+tT...L.sIRsELpssYc-LRpsap...ss-..ElFsMLTGET.-.........................................	0	70	117	174
+14730	PF14879	DUF4489		Domain of unknown function (DUF4489)	Coggill P	pcc	Pfam-B_28643 (release 26.0)	Family	\N	27.00	27.00	28.20	76.20	26.50	18.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.86	0.71	-4.51	17	32	2012-05-17 11:57:03	2012-05-17 12:57:03	1	2	17	0	15	29	0	140.70	37	79.89	NEW	spsIlKCG.ssGusslPssos....hussasluolTlDTsshpsPCl+LEFsSNIsssssh....solNFQlaKpCcsQhsPlPVGPsao.Fut..........hluhhtopoF.SFhVCDC.DhCss-.CCTYSVssTssu.hsssushoIsNAsLuAIss-s	...spslLKCG.ssGu..sslPhsos....husshslAololDTsshcsPslpL-FuSNIsssssh.....thsLNFQlFKpCcsQhhPhPVGPsas.Fsp..........................hlsshsopoF.SFhVCDC.DsCssc.CCTYSVssossu.hsssusssIsNAsLuAlhss...	0	6	15	15
+14731	PF14880	COX14		Cytochrome oxidase c assembly	Coggill P	pcc	Pfam-B_122767 (release 26.0)	Family	COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase [2]. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14 [1].	25.00	25.00	25.20	25.00	24.30	24.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.73	0.72	-4.34	45	167	2012-05-17 14:06:12	2012-05-17 15:06:12	1	2	159	0	124	156	0	57.10	23	37.66	NEW	thhsttc+lhDtsHRssVhoLlGhTshuushhsas.....haphhpa.+pp+t......h.tpccpt.t	......h....hucphsDhsH+ssVhollu..hTlhuGhlsshs.....hhphhphp+pp+t......h.ppph...................................	0	27	55	96
+14732	PF14881	Tubulin_3		Tubulin domain	Coggill P	pcc	Jackhmmer:Q9P6K5	Domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Misato from Drosophila and Dml1p from fungi are descendants of an ancestral tubulin-like protein, and exhibit regions with similarity to members of a GTPase family that includes eukaryotic tubulin and prokaryotic FtsZ. Dml1p and Misato have been co-opted into a role in mtDNA inheritance in yeast, and into a cell division-related mechanism in flies, respectively. Dml1p might additionally function in the partitioning of the mitochondrial organelle itself, or in the segregation of chromosomes, thereby explaining its essential requirement. This domain subject to extensive post-translational modifications.	30.00	30.00	32.00	30.20	29.40	29.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.21	0.71	-4.81	18	276	2012-10-03 12:11:42	2012-05-18 09:44:05	1	11	230	0	183	277	1	185.30	29	35.18	NEW	sPpLTo-oVRYWSDFNRVFYHPRSIVQLN-Y.EL..NSp..lM...P...F...EcWssGE-LFssLDKEHDLLDRDlRPFAEECDQlpGlQlFTGsDDAWGGFAA+Yl-RLRDEYGKpuh.hWsa.ul....psshptptph.h.+.phtt.h.NpARSlppl.us...QuShalPl........s........p........l.........s.........c....s......pS..t.....WasSALlusAlESsTLPoRL	................................................psl+hWSDa.+lhaHP+Sls.lp.........pa..ph.........ssp.............hh.................t.........F.........-s...au..hGpslap...p..s...hp...c...-hh.D.......R...........lRhalEECD...tLQ...GhQllsDhcsuauGhuu..phl.-pLpDEY.......spps....h.....h.....a.s..h...sh................t.ss...t....t......p..t.p....t..........pp....h.h.chl..NsAhuhsplsp.....puo.....lhsPlu.............p.................s.............ss.................pp.a.asSAlhAsAl.-oholPhRl.............................................................	0	53	95	145
+14733	PF14882	GHL12		Hypothetical glycosyl hydrolase 12	Coggill P	pcc	Naumov D [3]	Family	GHL12 is a family of hypothetical glycoside hydrolases.	27.00	15.20	27.70	16.40	26.00	15.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.80	0.72	-3.87	38	137	2012-10-03 05:44:19	2012-05-18 09:59:44	1	19	28	0	72	140	139	48.70	34	25.22	NEW	EYpc+YKcDP+LPSsPsphY..pc.-Wp...uWhsFLGsp..pchYsTht-AppAshpL	............Yhp+Y+cDP+LPusPpp..hY..ps.-Wt...uWhsFLGs...t......t...hY.ohttAptus.t.......................	0	16	28	48
+14734	PF14883	GHL13		Hypothetical glycosyl hydrolase family 13	Coggill P	pcc	Naumoff D, [3]	Family	GHL13 is a family of hypothetical glycoside hydrolases.	27.00	27.00	47.50	45.90	23.10	22.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.90	0.70	-5.26	12	474	2012-10-03 05:44:19	2012-05-18 11:51:12	1	3	410	0	61	295	6	291.70	52	48.30	NEW	HIDLDYVYDsD.tQps+NLshLlpRlhchtlooVYLQAFuDPDGDGhADAlYFPNRaLPhRADLFsRVAWQL+TRAuV.p.VYAWMPVLuaDL....P.s.sp..ptphlssp....ph.t.....t...cs.......hh..RLSPass+spphlppIYEDLAht.AtF-GILFHDDAhLs.DhE..................hs....th.p...st....u..............s........t.................h..........KopsLlcFThpLsstl+....th....c...Ppl+TARNlaAtsllpPpuEsWFAQsLsshhpuYDhTAlMAMPaMEs..sp.....p.....scpWLtpLlstVcspssuhcKolFELQuhsW+..s......pps.lspspLhsa.hphLQtpGlhsaGYY	........................HlDLDYVYD.s.pQ.-+NlDhLIpRlpDMploTVYLQAFA...DP.......D......GDG...h....l.....c....p.VaFPNRhLPM+ADlFuRVAWQL+TRuGV.p.lYAWMPV..Lu..a..-L.....P.s..ls...c.h..chlsst.......pt.c......scp........Yh...RLSPFcscsRtplt.lYEDLAta.AsFDGILFHDDAlLS.DaEDASssAlpA.......YpphGhssslucIR...ps....sp.....pht............pWsR.................................a..........Ko+sLsDFThELsspV+sh....R...uPplKTARNIFAh.PllpP.-.SEAWFAQNhsDFLc.sYDaTAlMAMPY....hEs....ls........-..u-pWLhp.Lsspl+shPtuh...cKolhELQApsWp..p......pps..I.soppLApWMphLphs.GspsaGYY..................................................................	0	14	31	46
+14735	PF14884	EFF-AFF		Type I membrane glycoproteins cell-cell fusogen	Podbilewicz B, Coggill P	pcc	Podbilewicz B, [1], Pfam-B_25631 (release 26.0)	Family	EFF-AFF was first identified when EFF1 mutants were found to block cell fusion in all epidermal and vulval epithelia in the worm [1]. However, fusion between the anchor cell and the utse syncytium that establishes a continuous uterine-vulval tube proceeds normally in eff-1 mutants and thus Aff1 was established as necessary for this and the fusion of heterologous cells in C. elegans [2]. The transmembrane forms of FF proteins, like most viral fusogens, possess an N-terminal signal sequence followed by a long extracellular portion, a predicted transmembrane domain, and a short intracellular tail. A striking conservation in the position and number of all 16 cysteines in the extracellular portion of FF proteins from different nematode species suggests that these proteins are folded in a similar 3D structure that is essential for their fusogenic activity [3]. C. elegans AFF-1 and EFF-1 proteins are essential for developmental cell-to-cell fusion and can merge insect cells. Thus FFs comprise an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle [4].	25.00	25.00	58.70	28.00	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-13.15	0.70	-6.45	4	33	2012-05-18 13:38:09	2012-05-18 14:38:09	1	2	10	\N	29	26	0	393.20	31	92.34	NEW	MhlhphlLhhhh.hhl.h..............s.Shh...hCscoh.hpu....psctsusplspThphQhpIGLppThCFhLp..sspc.S...sl..uh.sp.pslLHsLpYEplEpcYPlcppYpFulPcl-osClC-CsuhuDhCsscstphscpt.ssTspp..shCapTYHPsQsstGC....sutpuclCCcl.hpPhps+.YVAh+lpQPhssssapas...hasppuhchap.hscpphps.sstspph..hschtplplth.s.ups.pQLcpGMYahs.psps.hh-ht...INclsE.shcKLGWhR.ptss.casVRsuclplpsAHhlpscNC+sQhphsphsupahhs.pts.s.pcaa.GptVEch.sWlRoV+l.-..souRplpVhpppusslsVtLp.hpossshshhactScLs-FouolplDt+SNRFhNlThhsspGolhGpl..Yp.sss+pssspatFosalG.pspspNsshRIuLPuhIN.GsphlCLpP.pcPs...pElC+hlsFpppALppshl.poWppu..cutCspsNp.sLtsFlu.LNPspWhpsls.......uhhEhhthslclshhlshhhlhhhlpp+slssl	....................h......................................hp..aCsc.s.hpup.....pts.pth.phhph.hphsLppshCh.h.......................ps.lHslph.phEppaPlptpY.FulP.lpssChCcC.t.tp.ss.p....................Chppahst.ts.sC.....s..sphCCtl......sh.ahAh+ltpP.s.hhhhat....at..s.t.h..ht.p.hp........tt.t...h.t.tphplth.s.uts.pph.pGMYa..ppsts...clt...lNEls-sshc+LGWhR..c.ss.ca.VtsuhlhhpshH+shlcNCKtQhahs.hsup..h.......................tch..tt.lp..psWlpsscl.-..to.RphhlsHtcGTslplulp....sp..s...p................shh+stScltsFsGoIhlDpcSNRhhNlThatupGpltGpl..hh.sst.hp.s.ashoh.hu.....phtsps.hlsLPu.ls.tsphlCl.ssp.ss...tplC+hl.a.pps.lc.sh....tpWpth...u.Cspspp.shtshht.h.P..Wh.shp.......shh-hhhhshclslhhhh........hh.h...............	0	14	16	29
+14736	PF14885	GHL15		Hypothetical glycosyl hydrolase family 15	Coggill P	pcc	Naumoff D, [3]	Family	GHL15 is a family of hypothetical glycoside hydrolases.	27.00	27.00	27.00	51.50	26.80	26.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.52	0.72	-3.77	16	26	2012-10-03 05:44:19	2012-05-18 17:04:23	1	2	26	0	10	26	0	76.50	32	17.93	NEW	hssussa.ttpsh.s.psssaau+chsGppl..pWpGast+aphhshs.....ssaRttWVstlsctlp..ss......saDGVhhDNsshs	..........pus.a.htpph.p.pptsWhA+cssGctl..EWp.s.YstHaQhtVWs.....ssYRttWlcpVsptht..so......saDGVhADNDlh..	0	3	6	9
+14737	PF14886	FAM183		FAM183A and FAM183B related	Coggill P	pcc	Jackhmmer:Q6ZVS7	Family	The function of this family of metazoan sequences is not known.	27.00	27.00	27.10	27.10	26.80	26.40	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.63	0.72	-3.52	36	120	2012-05-22 14:57:57	2012-05-22 15:57:57	1	5	77	0	86	127	0	103.70	30	53.97	NEW	plh+EhlcKEp+p...+lhsp.FslsPhpph..slTpKP.sph.......................s.tc.ppstphhphhp.....ctpppPpcKash.PhTpuQEhGWhspshhp..........tpcpphpas+pps-lTpas	...................................................................tlhpEhhhKE.+p...+lhsp.aplsPhp.........phh..slTcKPhuhp...................................................ssh-t.ssscaLphl+.....+sspsPpcKYsh.PpTEuQElGWhspsllp.t................ppcpphpa.+hps-lThah.............	0	40	49	66
+14738	PF14887	HMG_box_5		HMG (high mobility group) box 5	Eberhardt R	re3	CATH:1l8y_A_00	Family	Nucleolar transcription factor/upstream binding factor contains six HMG box domains. This is the fifth HMG box domain in these proteins. This domain has lost DNA-binding ability [1].	25.00	25.00	25.00	25.00	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.05	0.72	-4.20	4	102	2012-10-02 14:16:02	2012-05-23 15:39:34	1	15	38	3	41	95	0	82.70	69	13.76	NEW	uKLPEoPKTAEEIWQQSVIGDYLARFKsDRsKA.KAMEuTWpNMEKKEKIMWIKKAAEDQKRYE......REL.EMRossAus.suuKKhKF	................uKLPEoPKpAEEIWQQSVIGDYLARFK.NDRsK.A.LK.AMEhTWsNMEKKEKLMWIKKAAEDQKRYE......RELSEMRuPPAus.sSuKKhKF....................	0	2	7	23
+14739	PF14888	PBP-Tp47_c		Penicillin-binding protein Tp47 domain C	Coggill P	pcc	CATH:1o75_A_04	Domain	Domain C is the largest domain in this unusual penicillin-binding protein PBP), Tp47. This domain is mainly characterised by an immunoglobulin fold with two opposing beta-sheets that form the typical barrel-like structure. In contrast to the classical immunoglobulin fold, however, this has an additional beta-strand inserted after strand 3. Also, the strands are connected by rather large loops. Helices are inserted between strands 2 and 3 and between strands 4 and 5. Domain C interacts with domain B via a surface that has a slightly concave, goblet-like shape. Tp47 is unusual in that it displays β-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP [1].	25.00	25.00	47.30	45.40	24.70	17.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.07	0.71	-4.63	14	25	2012-05-24 12:59:46	2012-05-24 13:59:46	1	11	25	2	2	24	2	159.30	51	20.57	NEW	ssTNGLKTAsKsuDGoFoFSAR.ssGTpSGlKDpsLKsA...sslsssVKpAo..GSYGEFLRVDLsGs.YGsLGAsMQAVKWTYYGsDSTYTpslAoYGTKFAADNWMHKuMGIQLGLTDSlRCpLPtGTDGTGYWolTVYALGYsDhTapFpATcpNIVKspsssss	..NTNGLKTAhKppDG.aoFSAR.psGotSGl+DtslcTA...oshpspl+suu..GSaGEFlRVD...Ls.G-.YGDLGuNhQuV+WsYYGDDuTYTsshASYGTKFAADNWMHKuhGIQLGLTcShRCpLPcGsDGTGYWpLTlhALGYpDsshcFpssttNlsp.t....pt.....	0	1	2	2
+14740	PF14889	PBP-Tp47_a		Penicillin-binding protein Tp47 domain a	Coggill P	pcc	CATH:1o75_A_03	Domain	This is the first domain in this unusual penicillin-binding protein PBP), Tp47 is mainly composed of beta-strands and is sequentially non-contiguous. The first three domains in Tp47 interact with each other through intimate domain-domain interfaces. Domain A contacts domain B through its N-terminal segment. Domain A also interacts tightly with domain C, Tp47 is unusual in that it displays β-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP [1]. 	25.00	25.00	55.60	49.50	19.40	18.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.13	0.71	-4.93	13	26	2012-05-24 14:39:44	2012-05-24 15:39:44	1	12	25	2	2	25	2	163.80	45	21.76	NEW	ptpsEYsYVYAGLTWuEYWAuEGVYAAGDTSSSsptDSHsEhDKGAFDsVTRATsNHGLHRGSaQ..CtAsIhscsGs..pYplSaWss.........ssphlLTDGos.loas.....RGs...ITpsDGootphscYcVsGlKYVPVKVKouDasAFcucYsVVENGupLsGGauENsLpSYp	........u.pcEapYsYAuLoWu-YWAuEtV.uAs.ssuuss-tDp+sEhDtGuFDsVoRATsNHGLHRGSFQssshlhuc..cuh.......saslptWpt.............tsp.slTcssp.sohs.......................Ruo.hhsDupphclspYcVpGhKYVPVtVtspDhsshKpKaplVEsut.L.GGauEtpLpsYp............	0	1	2	2
+14741	PF14890	Intein_splicing		Intein splicing domain	Eberhardt R	re3	Jackhmmer:D7E146	Family	Inteins are segments of protein which excise themselves from a precursor protein and mediate the rejoining of the remainder of the precursor (the extein). Most inteins consist of a splicing domain which is split into two segments by a homing endonuclease domain. This domain represents the splicing domain [1].	26.50	26.50	26.60	26.50	26.40	26.40	hmmbuild  -o /dev/null --hand HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.82	0.70	-5.54	5	448	2012-10-03 10:25:13	2012-05-25 15:14:27	1	159	235	3	197	474	68	305.80	19	35.05	NEW	DSLVpLsDsGh.VsIK-LVGcs-FsVlAlNpcThKLEoApVo+sFsTGsKPVFcLKTRLG+oI+ATANHKFLTI-GWKRLDc....LsssppIuls.........................................................................................................................................................................................................................................................................................................................................................................................E.htplushsQs..l.thspocIYWDcI.lSIpPsGVEpVYDLTVPsLHNFVANNIIVH	............................................................................................................................................................t........................................................................................h.t..h...h....p....s..p....lhc.....lpht.Gtpl.psTssH.hh..s...h.p...........s...............h.....p.........l....tp...........Lp.G-h.lshs....................................................................................................................................................................................................................................................h....h.................................t....t.......h....h.......huhhhu....-...G....h......................t............................................h..............p.....................h.t........................................................................................................................................................h..........................................t...t.....h...Pt.lh.t.........h..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....................................................................l......h.h..p.....s.c..h....h....a......c....pl...h...pl.p..............s....p.....VaDh.p.l...t..Hsal.uss..h.......................................................................................................................................................................................................................................	0	47	107	153
+14742	PF14891	Peptidase_M91		Effector protein	Eberhardt R	re3	Jackhmmer:D3QNI8	Family	This family of proteins contains an HEXXH motif, typical of zinc metallopeptidases. The family includes the E. coli effector protein NleD, which cleaves and inactivates c-Jun N-terminal kinase (JNK) [1].	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.19	0.71	-4.20	13	118	2012-10-03 04:41:15	2012-05-28 13:09:29	1	14	96	0	40	155	31	175.40	23	37.51	NEW	ssstlphcGo-.cFtc+lcAuLD+luSosTGcphLpsl.....pohsp....s+pcclsIsEtsscpsssspsshstp..............................GsssplshNPs.p..ht.s.tts.hp.s...t.ssslLhHELhHsachLsGop.....tsp...s.....spssssst-EtpAVGLstasa-..tps...............hoENulR-EhGhP+RspY	........................................................................................................................pss.p..phhpphpssLphltss..sGpthLptl.........pthtt..........tpcplslp...t.s.p.ss.s..ttshsht.ht.......................................stGsssplphsss.......ht....s..sssshp.....t.t....t..hssLhHELlHAhchhsGsh.....................tsch...st.................pptsshsppEhcsVGLst....aspp.................................................hoENtlRpEhGhshRppY......................................................................................	0	19	23	33
+14743	PF14892	DUF4490		Domain of unknown function (DUF4490)	Eberhardt R	re3	Jackhmmer:Q5BN46	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 101 and 220 amino acids in length. In mice, a member of this family whose expression is induced by p53 may play a role in DNA damage response [1].	27.00	27.00	30.40	29.70	26.30	22.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.31	0.72	-4.39	11	94	2012-05-28 14:49:04	2012-05-28 15:49:04	1	1	70	0	62	110	0	94.10	31	61.20	NEW	hpppssctptp.hps+sss...+TS-hY+lscsLPpR..FsNPspF+GYus.ps.ssshYRTSNppYGphsPTsHEhPpsFaPpspKFSpclstuGMaRssuLNThl-KSh	........................................................................pptphh...tp..l.tR..hpsP..F+GY...ts.pc..ssshY+ToNpsYGth.sP.......osaphPppaaspsppFS............pplstsGha+sssLNshh-cp.h...............	0	31	36	49
+14744	PF14893	PNMA		PNMA	Eberhardt R	re3	Jackhmmer:Q86V59	Family	The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders [1,2]. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis [3].	25.00	25.00	25.00	25.00	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.42	13	255	2012-10-02 13:37:57	2012-05-29 14:18:52	1	13	30	0	128	295	0	253.30	30	58.05	NEW	M....ALsLLcDWCRGMslNs+RuLLIlGIP--CuEsEhpEuLpAuLtPLGcYRVLG+hFRRE-NuKAALVEluptlNhoLlP+cIPG+GGsWcVVF+P.ssDsEF..Ls+LscF.LcsEGpsh..p-luRsLGssstsssst.s....p...Wscslupsl..shQPhh.EshtYpcL+lFSG....p-pPusGEEoFEsWL-Hss-hlph...................Wp.VSEpE+RR+LlESLtGPALcllpsLhtpNsshost-CLtALtplFGsp-sptsspl+aLsssQcssEpLpA....aVlRLEsLLQKAVcKuAlp.sssssQsRLcQVLutAphspsLps.......+L+hhphcppP.PuFLpLL+	.............................................................h.hLp-WC+..ths.p+shhlhGIP.tht........-hptslp.sh...s.aplhthhhhpp.t...pssllphstthshshlPpch..GpG..GsWcVlhps.s.-s-h..hpplp.F.Ltt-G.s.h...tshst..hlt.ts...s....t.........hsc.hs.h...h.ts.pshh...hhh...pphp...lFSG....pt.st..t.cEsFc...sWh...pssp..h..l.........................Wp...h..s-.E+h++lhcsLtGsAhpl.hphlttpNsths.stphLpuht.sFGs.-s.....hshph+hhps...Qt.sEphps....alhRLEshLppshppssht..ptss......psRlp..phh.tu.hst...........phc....h...h....t......ttt..Pshhthh...........................................................	0	32	35	40
+14745	PF14894	Lsm_C		Lsm C-terminal	Eberhardt R	re3	Jachkhmmer:Q8ZVU2	Domain	This domain is found at the C-terminus of archaeal Lsm (like-Sm) proteins [1].	27.00	27.00	63.20	62.30	20.90	17.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.02	0.72	-4.46	14	43	2012-05-30 08:12:54	2012-05-30 09:12:54	1	3	42	28	23	37	0	62.80	46	43.66	NEW	h+EFA-hlp+...lhPshVKlh-EsslVhV.-+l+VoEpGV.EGoGPhApRlhclacEYlcp+Kc	..REFA-hlpKphtlhPu.VKlhEEssVVhlh-+l+VScsGV.EGSGPhApRlhcLYp-Ylpc+K+..	0	6	11	16
+14746	PF14895	PPPI_inhib		Protein phosphatase 1 inhibitor	Eberhardt R	re3	Jackhmmer:Q96LQ0	Family	This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes [1].	25.00	25.00	27.10	26.00	22.60	19.50	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.13	0.70	-5.71	17	94	2012-05-31 15:19:19	2012-05-31 16:19:19	1	3	58	0	59	99	0	304.60	35	76.71	NEW	asDLpc..AcERYIpTNG..............aKFLRTlsQEEElIFRptFsRscsoaDt........DTVllsDlRDLVLFhMPcEFLo..hKFlpFMHpPsVaRLLHuLlIYFEYaLRhVEFlLIRRDELuGphuQlQSEQTN-MKRlaShYLSQYRhLVARNYshIlpGEGDhscaYHh....KcllNI..SuTI+D+hFHEQFLAVuTQIVWIsMHRRAYhlIEMEMNRLFRSEHFlhsR.EYL.........cFTssERSLLYGRssKlhNYRsQhSPLlQELpplscEDhPILWIGERKYRGoDhRIsplELEYlVPGsQL+hIDVuHGILGHPKpLYN..TlL............sLDWPuVRauNaS.paDPYallRQPpLcIPpIs-hphRKh	.......................................................sh.p..hcE+hh.spu..............h+Fhch.s.tp-hlhcpth.st.tpsp.s.................sslslpDl+.lsLhLh.pp.....hp..hpF.hpFM+p.slcphLhALlhYhpaaLchsph......Ehpsp...h.lt..ppp-hchhhSh...LpthphhlAppYshllhG...u.hschaHM....Kp..pI..SsT.+DhtFaEpFhshss...lsWIsh+Rpta.p.I..............E.Ehs..............RLFRochFshs.Rtch.....................ch..T.sphph.h..hu........+pst.lh.p.......hhs.pSPllppLh.s.cEch....lsc+KY+tssh+lsthp.c.hlsshspl.h.sV..GILGcP+pLas..TlL............sL-..t....shp...hc...lhcpsthpI.ph.th.h+p......................................................................	0	16	18	37
+14747	PF14896	Arabino_trans_C		EmbC C-terminal domain	Bateman A	agb	Pfam-B_4670 (release 7.5)	Domain	Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the   macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1]. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate [2].	25.00	25.00	28.20	27.20	18.40	24.40	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.30	0.70	-5.87	7	454	2012-06-06 15:10:05	2012-06-06 16:10:05	1	7	175	1	94	412	0	346.80	41	34.95	NEW	EluShstGhVtpYPsYosGpANltALsu....ssCuhADDVLVEsDsNAGMLpPlPut.aGs.GPLGGhsslGFsPsGVs-clpu-PVhppPGpsso-s..sps.ls.u.pssT.uGshussGlNGS+shLPaGLDPsRTPVhGSYsps.p.sAphoSAWYpLP....spst..s+PLVVVoAAGtIhuhp..tsh.hGQolcLQWusscPsGsh.PhuplpPhDl.GspP.AWRNLRaPLo.hPs-AsssRlVApD.sLosppWlAhTPPRVP.LpTLQphlGSpsPVhhDhtsuhsFPCQRPFscphGVsElPcaRIlPDhhtttssSshWpsutsGGPhhhhphLLRsoslsTYL+cDWaRDWGSlc+ah.lVP.DttP.Atl-.GohThsGWhpsGPlRhh	..................................................................................lsShst.uhltQYPsaSsutuNlpAl....sG....ssCulA-DVLVEsDsNsGhLpP..l....s..u...p........h.....us.....................s...L..........u.u......s.......s.....s..hGFsPsGls.....p.clp........u.-........s...............hh.....t.......ps......u..............ts.s.s..............s..s.........s....ts.............s........sts....u...s............T.........s....G.t.t...ussGlN....G.Sp.stLPasLDPu+sPVhGSa.sp....s..........p...........AplsSuWYpLP.....tp.st......stP...L.lV.VoA.AGplts.hc........t...h......Gp...pl......hlpauh......s...t.....s...s..G....s...h...p....s.h.G.p....h......hD...l..G.s..........tP...uWRNLR...hPhuthPscAsslRlVApD.sLsscpWlAhT.PPRlPpLcoLpphlGSssPVL.lDWsVuhsFPCQRPhsc.t...GVsE..lPc..aRIhPDt.sttssoshatsttsG.GshGhs-hLhcspslsoYLpsDWhRDWGulpcap.hss....stt.....P..Ap..lphGohT+oGhWpP.GslRh.h....................................................	0	15	64	85
+14748	PF14897	EpsG		EpsG family	Bateman A	agb	Jackhmmer:B0MX13	Family	This family of proteins are related to the EpsG protein from B. subtilis Swiss:P71056. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.72	0.70	-5.51	270	873	2012-10-03 03:08:05	2012-06-06 16:27:04	1	2	639	0	156	806	120	316.40	15	89.49	NEW	hhhhhhhhlhlhhhsuh+h.ss........s..Dah...sYh.phapp.ht................................hthE......Gahh..lshlhph.lsts......hthhhhlhuhlhhh..hhhhhlp+hsp..........hhhshhha..hhhhhh.h.....hRQslAhu.l.hhh...u.ltalh.....c+c.....hhtall....hlllAshF.H.tSu...llhlsh....hhlhp.hchp..........................hhhh.....................................................................................................hhllshh...........lhhhhhhshlhphhs.h...................phstYhptsthstsh.........hhthhhhhhhhh..........hhhhhhhhtppht.....................phhhhhhhhsh.hhhhlhhhh............hhhsRlsh......aahhhhh......hlhshlhp.............hhptp...ppp..................h..hhhhhllhhhhhhhhthh.h................hhPYps	..............................................................................h...hhhhhhhhhhhsuhRh...th........us..Dhh..sYh.pha.pt.htt.................................hth.E....ua.hh..l....hl.h.ph..h..s.ts.......h.hhhhlh...sh.ls...hh....hhh.......hhhtc.h.spt................hhlslhla....hhhhhh.hh.ph.stl.Rpsl.Ahu..l.hhh.......u.lh..hlh.............pcc......hhphhl....hlllA.sh.F.H.hSu.....llhl.h..........hhlhp...hphp.................hhhh.....................................................................................................hhh.h..hhh.........lhhh...hhh.s.lh..shhs..h..............h.t..............phshY.hptt.tttth........................hhthhh.hh.hhhh........................h..hhhh.hhhttpht........................thhhphhhhsh.hhhhhhh.h..........hhhsR...hsh..hhhhh.h..hhlshhlhp..........hhtpp....tpt..............................h.......hhhhhllhhhhhhhh.hh.....................................................................................	0	50	103	133
+14749	PF14898	DUF4491		Domain of unknown function (DUF4491)	Bateman A	agb	Jackhmmer:B0MXX8	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.	27.00	27.00	42.80	42.60	21.70	20.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.11	0.72	-3.84	40	168	2012-06-07 11:57:47	2012-06-07 12:57:47	1	2	159	0	29	132	11	92.20	53	89.23	NEW	hsapGllIGlsoFlIIGlFHPlVIKuEYYFGp+hW.lFLlhGIsslssSLhlpsllhSulLGVlGhSsLWSItELaEQc+RVcKGWFPcNPKRK	....phsGllIGlsTFLIIGlFHPlVlKuEYYaGo..+.sWhlFLllGIsslluSLhlcslhlSulLGVhuhSshWoItElFEQccRVcKGWFP+NPKR+......	0	18	27	29
+14750	PF14899	DUF4492		Domain of unknown function (DUF4492)	Bateman A	agb	Jackhmmer:B0MUW2	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. The function of these proteins is unknown.	27.00	27.00	35.40	35.20	21.80	19.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.02	0.72	-4.47	47	245	2012-06-07 12:06:30	2012-06-07 13:06:30	1	1	244	0	25	127	0	64.10	55	83.98	NEW	hh+lachYhDGFRsMT.LGKTLWhlIlIKLFIMFslLKlFFFPshLppp..tscp.p+.usaVtppLhp	.....pIFsFYhEGF+shT.LGKTLWtIIhIKLFlMFhILKLFhFss.hsoh..psDpEKusFVhcpLh....	0	11	22	25
+14751	PF14900	DUF4493		Domain of unknown function (DUF4493)	Bateman A	agb	Jackhmmer:B0MWC6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 264 and 710 amino acids in length. Many of these proteins have a lipid attachment site suggesting they are lipoproteins.	27.00	27.00	27.30	30.50	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.71	0.70	-4.74	66	146	2012-06-08 12:54:42	2012-06-08 13:54:42	1	5	36	0	25	139	5	229.40	19	45.16	NEW	pspGhLp.....Lslsss..............ssstT..+ussstt.t.......ssssatlpIhsss....sthhpptphsphs......ttlpLssGs.YslpAp.hu..-ssss..uhct...PaY.tGpp.shslpp.spsssss..lsCpluNstlslsa....sps.htshF.ss.....aplpVssu.........ssslsa.......tscs...cssYatssp.........pl..phslpuspp.s.s...spstph...................pslpsssph.plshshs..................psGss......slslslsps.spshshslplssph	......................................tpGhLp.....Lslssp..............ssstT.+usspt.................phpsaplpIhsss.........sslhp.sshschs......ppltLssGs.Ys.lpAh.hG.......-ssssuh-p.....PYY.tGpp..shslpp.spss.sls..lpCpluNstVolpa.........scs.htphF.ss.........aslsVssu..........ssslsa......ttsps...cssYapssp...........pl.phslpuspp.s.s....spptsh...................pslpstppa.plshshp...........................psuth......slslsl-ts.hpphshshtls...........................................	0	5	20	25
+14752	PF14901	Jiv90		Cleavage inducing molecular chaperone	Coggill P, Hetherington K	pcc	Pfam-B_1192 (release 26.0)	Domain	Jiv90 is a fragment of the DnaJ protein in eukaryotes and in J-domain protein interacting with viral protein (Jiv) located in the N terminal region of the pestivirus viral polypeptide.  The viral protein interacts stably with non structural (NS) protein NS2, causing a conformational change in NS2-NS3 and stimulates NS2-NS3 cleavage in trans. Cleavage of NS2-NS3 increases cytopathogenicity and consequently aids viral replication. Jiv therefore acts as a regulating cofactor for NS2 auto-protease. The efficient release of NS3 from the viral polypeptide by Jiv is considered crucial to the pestivirus cytopathogenicity [1]. In eukaryotes, it usually lies 40 residues downstream of DnaJ family Pfam:PF00226. However, the function in eukaryotes is still unknown.	27.00	27.00	27.90	27.90	26.20	16.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.33	0.72	-4.00	20	161	2012-06-08 14:47:20	2012-06-08 15:47:20	1	17	91	0	88	157	0	93.00	51	11.91	NEW	puupsItCspCsshHhthtTc+.stupARaCpcCphhHsA+-GDlWsEsshhGhha.........+hYsCh-upVYDIT.............EWAsC..Qthth.......psNTHpVpa+lshs	.....EshNThhCo+Cts+Hh.RhphcR.p.tsARaCs-CsphHsAc-GDhWAEoS.hh.GL+h.........pYFAhMDGKVYDIT.............EWAsC..Q+sul.......sPsTH+VsYHIshu..........	0	20	36	62
+14753	PF14902	DUF4494		Domain of unknown function (DUF4494)	Bateman A	agb	Jackhmmer:B0MZU7	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 172 amino acids in length. There are two conserved sequence motifs: VDA and EAE. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	77.50	77.40	23.30	22.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.69	0.71	-4.57	28	161	2012-06-11 12:23:02	2012-06-11 13:23:02	1	1	137	0	32	137	51	139.90	55	85.59	NEW	WFEsKl+Y-KshE.sG..........hpKpVoEsYlVDAlSFTEAEspIhEEMusal..o.GEFclssI+pAsYuElFFs-h-ssD+....................WaKuKlpFITlDEKotKEK+ossshLVQAsolppAlcpl--sMu..sThlDYsIsulsETpIMDVF.ap	.WFECKlRYEKshE.sG.............hpKKVTEsYLVDALSFTEAEuRIIEEMosaI..S..GEFsVosIK+AsY..uElF...S-t-suDR....................WFKsKLhFIT...lDEKS..G....tEKKTssphLVQAssl+-AlK+l-EsMc..uTMuDYpIuulsETsIMDVaPY......	0	12	28	32
+14754	PF14903	WG_beta_rep		WG containing repeat	Bateman A	agb	Jackhmmer:B0MSK5	Repeat	This repeat contains an N-terminal WG repeat motif. The extent of the repeat is poorly defined. This repeat may form a beta solenoid structure (Bateman A pers. obs.).	25.00	11.50	25.10	11.50	24.80	11.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.34	0.73	-7.86	0.73	-3.53	486	4416	2012-06-11 14:25:50	2012-06-11 15:25:50	1	86	508	0	1201	4277	336	36.40	27	39.14	NEW	aGh.....lsp..pG......ch.l..l......s.s.p...Ycp..............h.....t.s...a...p..s....u........................h.shV..............p..p..s................s.....................................c.........a	...................aGa..lcp.pG.......ch..l..l......s.s.p........Y-p....................................s.........t.s....F....p..p......G..........................................h.AhV..............p.....t...............t.........................................................................................	0	586	987	1110
+14755	PF14904	FAM86		Family of unknown function	Coggill P, Hetherington K	pcc	Jackhmmer:A6NEL3	Family	Function of this protein family is not known.	23.50	22.10	23.50	22.10	22.90	21.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.28	0.72	-4.26	3	140	2012-06-11 15:45:07	2012-06-11 16:45:07	1	5	47	0	46	98	0	79.80	52	31.85	NEW	MAPEE+AGAspLLQGFERRFLAARALRSFPWQSLEEKLRDSSGSELLLDILQKTVKHPVCVKHPPSVKYSRCFLSELIKKHEAVHTEPLDcLYEALAEVL	.................................ttt.lLpsFpR+FLAsptLtoFPWp...S...LEtKL+...-SSs........S..E...LLp...DI.L........p.KT...V......tHPlCl+aPPSl+YtppFLoELI+KpEusth-slDpLYcsLsph..................	0	19	21	28
+14756	PF14905	OMP_b-brl_3		Outer membrane protein beta-barrel family	Bateman A	agb	Jackhmmer:B0MXY4	Family	This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-12.97	0.70	-5.81	316	2158	2012-10-03 17:14:37	2012-06-12 10:57:21	1	25	394	0	605	5700	1826	472.30	13	60.34	NEW	s..tp...h.p...p......p...s.p...s..p...sp.s.p..s..h..sh..phuh..s.Yp..l......ss.....pp.sluh....phshp...hst..tpt...ps...................sspsp..........................tth..............ths..pppppp.ptppt..shshsltYptphs.p.sp..p..lsh..sh..s..a..sht..ps..ss.......ppp..hpp....p..h...............t....ppph....t..sps...pp..p.phhssplsaspsl.s..c......t..plphG.hchshspsp.ssh...h....t.hp..............s.t...th....................................................................s..........s..ssp.......hphpcphh..usYssas...t.p.h......s..+....h.sh..psGlR....hE..h....sp..h......................ph...pp...........t..h.t.p.......p.....p............psa.hs..hh..Pohs..lsa...phspt...p..lplshspchhppPshtpLss.hhp.ht.s.s.hshppGNPtLcPp..hspshpls...a....s.h.....c..pt........h...phs....hsh..pa..s...pst...h.........th...s..h.h...........pt..........s.p..ss..........................................hh..hhp.tN..h.spp.pph..shslshsh...ph................sph...hphs...........h...shshhht.p.p....s.................s....st..hs.................................................................................hs.....h..........sp..h...s....hth....ph..s..s..s..............................................hp..l..s.....p..s.hphphsht..ap...sps..hps....................p.........................................h...t....h.psh.hh.hshulp+shhc.c+.hslslpssDl....Fssp...p.pt..tpht....hss...hhp....p.....ph...pspt.hhlslsY..pF..spt+	.....................................................................................................................................................................................................................................................................................................................................................t......................................h.....phthp.a..p..h......s.p.......p..tl.th.......th..t.h.t..htt....pt....t..........................................t..t........................................................tttt..t.......pt...thp.hsh..h..p...t.....p.h........s.......tt.....p....l..s..h.........sh..p......h...th...pp...pp...............pp........htp.........h......................................................t..........pps.................pt..p..t....p...h......t.h.p....hs....a....p......hs......h...s........p..............h....pl...ph..G...hp.h.p...h..p...p..pp...s.s.h........h.....ht...............tt..................................................................................................................................................................................................................s.......t.......t...s.s.p...........h..p..h...p......p...p..h....h....shah..p..hp.....h...p...h...........s...c..........h..s..h....ps..G....l+....h-..........s.p...h.....................................................................ph....p...................................t.t.........p......p...............................psh...h.....p......hh....P..sh...p..l..p..a....................phspp....p....lp..hs.a..sp......p..........ptPs....h........t.........p.........L.........s.............s.......h...........h.................p.......h.............t.........s..........s.......h..........p..............h............p.........t.............G..............N............P......p......L..cP.......p...hspshpls.........a.....p..a................p..pt..........h........hs......hsh...thp........pst...........................h....t...h.h...........................t..ss..............................................................................................hh....hh..p.....t.....N......h..s......p.s...pp.....h....s..hp..hsh..sh..ph...............tph.....h...p.h.p...........h...sh...s...h...t...h..p..p...p....s...................p.......t..................................................................................................................................................................p..........p..t.....s....h..th.........ph.....s.sp...............................................................................................hp...h....s........t...s......h....p.h.p.....h..s...ht.....hp........stt...h.s.....................................................................................................h..h...........ps......h.h...h........shs..lp.h..p.......h......h.p....p........p....h.....p....l.....p..l..p..sp..s..l........hp......pt.......h..h.......p..h.......s.t...............p.............................tp.....hhlshpYpht....................................................................................................................................................................................................................................................................	0	234	513	586
+14757	PF14906	DUF4495		Domain of unknown function (DUF4495)	Coggill P	pcc	Jackhmmer:Q8IV33	Family	This domain family is found in eukaryotes, and is typically between 322 and 336 amino acids in length. There are two conserved sequence motifs: QMW and DLW. Proteins in this family vary in length from 793 to 1184 amino acids.	25.00	25.00	28.60	36.10	21.80	17.90	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.16	0.70	-5.48	10	82	2012-06-12 11:20:08	2012-06-12 12:20:08	1	3	65	0	58	84	0	292.90	43	32.31	NEW	scFVpllsKsAsplLE+L+plupEslc+AsLssL.....pusLuuAuhV+NpLhpYsphhp.......ssscpshlphSYcpYpEhsEuLsEpllDhHsRlluhhILQDADShaW-s.+sFaEGERCSFsIQMWaaYhpuh+pDLWshlPPKhAQ+lhAuMLp-SLolLosRYoQupPShsRosQlhlDIsslLLCosphLhSlCsoupchlss........p.sspSKIh+.IHs+CspLhssLllcuoPLssLYKlF++Gl-.shs....hhpspttpPs.Wlhhh...hPsLhp...........hchoslssshAlplpLKlLLuQPpssWsLLL+lLLM+cshls+lLL+pohps	..........................s.pFVphssKsAstlLp+LpchupEs.s.+AsLpsL.....pshLusAshVhpphtpYpphhp.........pspKpshhhlshppYpEhhpsLt..plhDhpsRlhuh.ILQDA-ShHW-Dh+sFaEuERCSaolQMWaaahhuh+pDLWshlPP+hAQcIhuphLpcoLulLssRYspspPShtRosQl.hhDlsslLlCstphL....hulCpSs..pthls...........p.tspspIh........+.IHs+CppLhssLllhsuPLs...LY+sFpcGhc.shp.......hpshht.PhhWl.hh...hPphht............................ss..ssphshp.hpL+lLLupPtssWsLLLcsLLh+DshLhpIll+p.h.t.............................	0	15	19	38
+14758	PF14907	NTP_transf_5		Uncharacterised nucleotidyltransferase	Bateman A	agb	Jackhmmer:B0MX79	Domain	This family is likely to be an uncharacterised group of nucleotidyltransferases.	24.60	24.60	24.60	24.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.51	0.70	-5.04	171	654	2012-10-02 22:47:23	2012-06-12 14:18:15	1	9	531	0	265	712	105	226.80	16	64.96	NEW	ssh-WpplhphAptpplhshlhpslp.phs...........................hss...t....tlht.ph...ppt..hptsttpshthttchtclhphh.ppp.sIpslhLKGhsl..u.p.hYs..sst.h.....RthuDlDlLl........pc...hp..c...........................s..pp..lL..tph.Ga.p..........h....p..t.....p.......................sp.p.....................................cth.a.h.p...........................ps..hh...lE..lH.ap....lh............t.t.h.........ph.h.....p.....p.h..htp...................ht..h...ph..ssps...l.........hshs..spchhla.hhhH.h.h.c...H..h.h.......t..........tth..sL.RplhDl.thh.lpp.........h.pp.h.........-..apt....lh.pphpchshtc.hhhhshtlspphhs	.................................................................................................p.......hh.....tth.shh...h........................................h..................h.....tt..h.tthtplh.phh.ppt.slthlhlKGhsh...s..t.has...p.t.h.............R..hsDlDlllt.....pc..htp...........................s.tp.hL.tph.Ga.p......h..pt....t......................stp...............................................p..hhht.............................ps...hh...l-..lH.ap.......lhtt.............h.........t..h.....s.....p.h..htp...................tp..h..pl..sstt...h.........hh.hs.spphhl..h.h.hhH.h...h..p...c...h.h.t............t..tl.p.lhDlth.h.hpp.........h...p..h....................................s..hpt....lh.thhpphth...h..hh.h...........................................................................................	0	93	196	230
+14759	PF14908	DUF4496		Domain of unknown function (DUF4496)	Coggill P	pcc	Jackhmmer:Q6ZN84	Family	This domain family is found in eukaryotes, and is typically between 134 and 154 amino acids in length. Proteins in this family vary in length between 264 and 772 amino acid residues.	28.50	28.50	28.50	31.20	28.40	28.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.37	0.71	-4.29	29	151	2012-06-13 13:08:07	2012-06-13 14:08:07	1	19	72	0	104	143	8	135.60	24	18.56	NEW	lpplWpslspalpcplttp+uVplsshGsFohph.p.th.s........................tcPsFllsccFhppaslpttp........t...........sptssspl.sasplu..ttsshs+-.hlcsslccllptluctlp..stpsl.plsh.ulGpLph.+spplphpF	.............ptlWtslupalpcpLthp+GVpIsshGsFohpppphphsstph...................hhhp+PlFlhsccasptasLpps+h..........s...............................schshhtl.Nastlu..hts.s..hs+c..slcsslcchlthluctlp..................ttpsl.phsh.ulGhLhh.+spphphpF................................................	0	55	65	85
+14760	PF14909	SPATA6		Spermatogenesis-assoc protein 6	Coggill P	pcc	Jackhmmer:Q9NWH7	Family	This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family has similarity to the motor domain of kinesin related proteins and with the Caenorhabditis elegans neural calcium sensor protein (NCS�2).	27.00	27.00	27.20	27.10	26.50	26.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.66	0.71	-4.13	17	142	2012-06-13 13:52:55	2012-06-13 14:52:55	1	3	68	0	70	133	0	124.80	47	36.03	NEW	tl-Lpl+AVT..CPGVaLss+sclYLslplhGpahcTpshPshFPlLhp-+hpFEKsFhsssssupls-hLcschlhlELlQhssss...GplLApapsssRDFLaPtsphhssh.sGssR-lLMcpo......sFPG.I.uPKlEFSTcosI	.................h.ltLplculo..CPGVhL.s+p-laLulhlhsQYhcTpshPssFPlhhpppMhFEK...lF.pAlDPusVsphLE..hhhhELlQls.ss....u-pLAhY--NTRDFhFPtPp.hsua...sssRpVLM+ph......uFsG.I.APKlEFSTposI..........................................................	0	16	20	34
+14761	PF14910	MMS22L_N		S-phase genomic integrity recombination mediator, N-terminal	Coggill P	pcc	Jackhmmer:Q6ZRQ5	Family	MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication.  MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse [1]. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants [2,3]. This family is the more N-terminal region of the proteins.	27.00	27.00	27.60	27.10	23.60	21.00	hmmbuild  -o /dev/null HMM SEED	704	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.34	0.70	-13.29	0.70	-6.29	4	99	2012-06-13 15:05:30	2012-06-13 16:05:30	1	8	63	0	55	96	0	462.00	36	57.13	NEW	PPCFoCsa-.sppss.phSupuYLusGuLKRllL+LDPtPssF-tDsl-lFuFtWVTETALVESC...phLFsLhRQQlhpLEsLlQ..SpDFGpAAoLHscA-plRpQClhFLHYlKVFIaRhLcs.ps.sc.tshHPacchEAQLPShLV-EL+uLhLhIG+lssLPussluAF.s.Q+QsKlFPPSWHLLHLaLDhHWLVLEILHlLuc+h.tQVVYuppFls.sG-sLTNlSLFEspsEpLhsDLIsLuhp+YsKV+PoEsLpopHa.CpCsKELWlLLI+LLtaRsKh.tsc..sFWshlNKhLpolhcpsostcp.suhuhspsKDPhuFohWlhsHLApLhpasRpG..ss-cpKQhEsNWpFltpLLKp.lssQsuh.EEQlRhaLpCCLoL.sphWpPNlSVlThLWEYYSKNLNSsFoVsWLsLcGLssIs+osLuhLphs+sCCSc.....pphssLY+ousSahIFLpILA+hlK...cpuGspPW+QlKGRIYSKFHp+RM.ELoEsGLppFhpLFLlL.AtsAElEDlAS+lhDLLthLs.suhs.supRALlW+GphAhLLlYspKsLDlushAEKLustFpptA+EFh..Ks.-.sp+.sLWslluhYl-GVQEVFETSssLshSEE+LLN-GFuhLLPACRpuELspVLsFLQsVlARLRpVHppsuQs.p..sss..s..s.sAKE+..A.VAuALWpHFFPaL+SQRho	............................................FpC...t..tt.t.....h...tualtpG..h.ph.....t.c....thp.t..ph.th.hVtphhhs.ss...p.Lhthht...tp.....p.hp........s.hsshp...th...phRp.psh.Fhphl....h..................................h.hctl..tl...hsp..th..s......hh........h..................................................................hh.hu...att........-..h..t.h.C.C.+EhWlhl..hh........tp....sFWthhpphhpthhpt....pt.............shs.htF.hWlhhplu.hhpa...sppG......pp....hpht.ssh..htplLKp.hss......ps......Ep....phRhhl.hhhsL.hthhps.sh....shls.LW-Yap+pL.N.ssFslsh..hptls.h.poshshlc.hpphhs.......t..pL.....sSahhalhlLuhhhp....ttstst..hpp..lhGRlaSKFptt+h.tLsE.Gl.phh.LFLhl..ht..-hp-lss...+h...hp.hL..h....l....t.........pt..lh.h.+GphuhlLha.p+thshsshsthh.t.thtthtp-.................hthhs.ahtsl.pplhphu....ph..upphLl..s.hhshhl.tst.sp.p.hhphlp.lhtplp.........................................................................................................	0	17	19	36
+14762	PF14911	MMS22L_C		S-phase genomic integrity recombination mediator, C-terminal	Coggill P	pcc	Jackhmmer:Q6ZRQ5	Family	MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication.  MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse [1]. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants [2,3]. This family is the more C-terminal region of the proteins.	28.40	28.40	48.30	29.50	27.70	25.90	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.89	0.70	-5.40	15	86	2012-06-13 16:19:41	2012-06-13 17:19:41	1	7	62	0	52	90	0	316.60	36	35.01	NEW	EplscLTphVhpLsEh+plh.cus.....hhpss+-PLstFFcAlG++hpp.cssuc..h+hphspKhcsYlscF-pWlsss...tp.ssthhpRhYshLulllhpCuslhYs+SKusChh+hhhs+hLLP.opLQsspsspspllpsl+KhaPllLQGlu...phsapsDsYLscpLcsllp+asP+Fhhsossthss+........h..hhpsss..spcLspalLppltspFlplpp.stsss+suhlLsllppLlcsh........pspsplhshlchltsulL-plhhVs-...s+thshslhphlVpssphppusts+pphssslpuhscKaLuhsTh.YFphLtcLAchsPclVtsLlspl+pplppsEhKRGsGcDsulRcsLpRLpssLp	......................................plhtLTphlhpLsEhctlh.cst........ssppsLh.FhcAlGhpattlQshu-...+oshspKsLpYlGclhKalpP.L..........tph.stuLplsYthhGhlVKphu.lhhT.SKuQpLLapllDsLLLP.s.Lppppt..s.hhpulpcsLPlaLQGhs...p.s.s.ssYLpphLtpllppYhs+FlsuSs..s.sht...............l....htsssss.hs....tLp+hllp...hlpcsalphcu.ptssP+LuslLsFl.pLhcc...............ps.tht.lchlLPulLcClhhV..s.......psps++hus-.lphhVpssp...htspttstsphsulhRpFlpcahhhashplaplLcslAhLs.plVhtLlsplppsL+poEhKhGlGcshu.Rpshp+L.shL.s................	0	16	18	33
+14763	PF14912	THEG		Testicular haploid expressed repeat	Coggill P	pcc	Jackhmmer:Q9P2T0	Repeat	This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions [1,2].  Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice [3].	27.00	8.00	27.00	8.30	24.90	7.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.12	0.72	-3.42	37	329	2012-06-13 16:25:20	2012-06-13 17:25:20	1	8	58	0	222	470	0	51.20	24	50.06	NEW	W.......slspuALcupsopRlppLAp...P+hhtshh.hphs..................tls.tAhtht......sosRlhcLupPpp	......................................l..tshph.sopRltpLAp...PKhhtshh..tps........................l.................................ch..hs........................................	0	93	104	146
+14764	PF14913	DPCD		DPCD protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9BVM2	Family	This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD) [1]. This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants [1].	27.00	27.00	43.90	43.60	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.13	0.71	-5.19	18	117	2012-06-14 09:39:13	2012-06-14 10:39:13	1	3	97	0	68	121	1	179.00	46	89.83	NEW	sWLshL+uAcKTullQDG+RKVHYpFsDGpEMAEEYDhcTspLlhR+WRpKusLGupGpWplElGEP.sssst..................psphlKEsuosPlFsR+sTKsuFpWRIRNLPYPh-sYoVTV-tcpRslllRToNKKYYKKhslPDLDRspLsl-pssLoasHtNNTLIIoYKKPcplLphEcplLpEL+KlKss..p-GDl	.................Whp.lpsupKoullps.G+RKlHahFsDGpEMsEEYDhcTspLLlRKWRhKs.s.L.Gu.upWplEVG-sss.ttss.h....................ssphlcESsusPlhhR.+DTKpuFpWRIRNLPYPc-VYuVsV-pcc....R....sIlVRToNKKYaK+hsIPDL-Rh.plsLcpstLSasHtpsTLIIoYpKP.tllt.hEppl.pElpplcstp....t............	0	26	31	49
+14765	PF14914	LRRC37AB_C		LRRC37A/B like protein 1 C-terminal domain	Coggill P, Hetherington K	kh6	Jackhmmer:A6NN04	Family	This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1) [1]. The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation [2].	27.00	27.00	37.10	35.00	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.91	0.71	-4.78	5	149	2012-06-14 09:49:06	2012-06-14 10:49:06	1	7	25	0	80	93	0	137.50	61	14.63	NEW	YPuLsSPG-QFEuQLNQQLRSLIPNNDVRRLISHVIRTLKMDCS-o+VQLoCAKLISRTGLLMKLLSEQQEsKlSKAEWDTDQWKTENYINESTEAQSEQKE.csSELsKEVPGYGYNNKLILAISVTVVVTlLIIIFCLIEICSHRRApcEDE	.....................................................P.h.SsGDQFEhQLsQQLpSLIPNNsVRRLISHVIRTLKMDCS-spVQls..CAKL....ISRTGLLMKL..LSEQQEsK.sSKs-WD.T-QWKoENYINESTEsQoE.QKE..c.sp.Eh...pKE.VPGaGYs.pK.LILAl.VTs..llhlLIIlFCLIp..l............................	0	13	14	15
+14766	PF14915	CCDC144C		CCDC144C protein coiled-coil region	Coggill P, Hetherington K	kh6	Jackhmmer:Q96IX9	Family	This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.	27.00	27.00	27.00	28.80	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.93	0.70	-5.50	17	241	2012-06-14 12:50:39	2012-06-14 13:50:39	1	41	38	0	86	211	0	241.80	46	28.85	NEW	NphLQ-EIAhLRLEIDTIKspsQEKEpKYhEDIcIlKEKN-sLQ+slKLNEEsLTpTlhpYssQLNsLpAENTMLsS+L-pEKpsKERLEs-lESa+uRLAuAlpDp-pSQsoKRDLELAFQRs+DEah+LQ-KMsh-lSsL+DpNEhLSQQLScsEuKhNoLEhELH+sRDuLREKoLhLE..plQR-LsQsQsQtKEhEphhQsEpsKlsKahu.KQESlEERLuQLQSENhLLRQQL-DApsKs-sKEKsVhslQcphpshlppLQA-sEKpsLhLcE+NKELhsEssaLKERhhpYEpEKsERE	...............NphLp-EIAhLRLElDTlKppspcKEpKYhcDlchlKEKN-sLpKslKLN..EEslT.......cTh.pYstpLpsLp.s....ENshLsScLppcKps+pRLEsEhcSapsRLsuAlp-tppp.ssc+shclshppst-..hplptphs.chuth..pschLoppLScsctKhpsLc.ch+.sp-sL+EKoLhlE..psQp-LpQsQpphKEhcphapstpsphpchht.KQpsl-ERlsQlppcNhLLpQQL-DAppKssspE+hlhsIQtph........h-scKp.hhLcE+NKcLhschsaLKEphhpYEpEKsEp..........	0	26	28	36
+14767	PF14916	CCDC92		Coiled-coil domain of unknown function	Coggill P	pcc	Jackhmmer:Q96LY2	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.	28.30	28.30	28.80	29.20	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.03	0.72	-4.38	15	147	2012-06-14 14:55:10	2012-06-14 15:55:10	1	2	59	0	90	137	0	59.70	42	20.86	NEW	hpp+lpslp+slpFLQppHtpsLcuLHpEIc+Lpccs+-LpacLhhppssps.ps.ss...o.sp...ph	......ppplpshpKsL.FLQp-HusTLcsLHt....EIc+Lpp+spDLpacLhhppsppp..tps...t.t..t...................	0	25	31	52
+14768	PF14917	CCDC74_C		Coiled coil protein 74, C terminal	Coggill P	pcc	Pfam-B_23141 (release 26.0)	Family	This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer [].	25.00	25.00	25.40	53.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.53	0.71	-4.08	6	31	2012-06-14 18:18:57	2012-06-14 19:18:57	1	2	22	0	19	42	0	124.20	59	34.53	NEW	tPhMsL...P.tLRKPTTLQQCEVlIRQLWNANLLQAQELpHLKSLLEGuQRP+AssEE.........AGhuuP.+DQ-.....uppLPKVosKulSKKCLlLS.ssV.AE+uILPALKQoLKsNhAERQ+RLQAVQpRRlHRo	...................PsMhL...P..LRKPTTLpQCEVlIRpLWNsNLLQsQELQHLKSLLEGoQR.PpAsPEE...........A..S.P.+DQE.....AhphPKVoo.KulSKKCLlLSP.PV.AERAILPALKQThKNNFAERQKRLQAhQ+RRLHRS..................	0	5	6	9
+14769	PF14918	MTBP_N		MDM2-binding	Coggill P	pcc	Jackhmmer:Q96DY7	Family	MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle [1]. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner [2]. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells [2]. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4) [3]. It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920. 	25.00	25.00	31.40	31.40	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.66	0.70	-4.99	14	53	2012-06-15 13:15:41	2012-06-15 14:15:41	1	4	37	0	28	41	0	239.20	56	30.94	NEW	MDRYLLLVhWtEtKh.usAutEhE.ts-houhcsopppPclpAsNlYHLLKRSIosSlpP-DSTFPACSVGGhPGS+KWFFAlQAIhGFYQFCSSD..WpEIaFssEKDcIEDVLQTNlEECLuAlECFEEEDSNSRESLSLA-LYEEuAEsLHQLSDKLPAPGRAMlDlILLsSDKDPPKLKDCLPslGALKHLKEWaSAKITIAGsHCEhs......sQKIAEYLSAsVVohE-l+NsID..S+ELWRGcIQIhERKFG.ElSFPEFCLKGVTscNaSs.NLNo	........................................................MDRYlLhl.a.............t...t.s...t......s.hs.AsslYchLKcShssSlps-sSTFP..ACSVuGhPGo+KWFFAlQAIhGFYQFCSSD..WpEIphsspK-c.EDsLQTslEECLuAlpsFEE-DsNSRESLSLs-LYEEuAEsLHQLSDKLPAP.GRAMlDlILLsS-cDsPKLKDCLPslGALKHL+EWaSAKITIAuscschs......hQKIA-YLSAslVu.--LpNsID..u+ELWRGKIQIhERKFu.ElsFPEFCLKuloscpass.plp......................	0	3	5	11
+14770	PF14919	MTBP_mid		MDM2-binding	Coggill P	pcc	Jackhmmer:Q96DY7	Family	MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle [1]. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner [2]. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells [2]. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4) [3]. It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14920.	25.00	25.00	39.20	39.00	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.09	0.70	-5.76	6	58	2012-06-15 13:23:16	2012-06-15 14:23:16	1	5	40	0	30	45	0	303.50	55	40.32	NEW	pcVFHYYGsALEaVQMVpLSDLPuhalSDhEFEL....uls++usKt.StLLL-QlsSLpGKVGALFsLsCslSslshPssuQLSS+KWREYhA+KPKsIsVPDVEVKGEpusYahLlQGsGsut...C+ATLlHSAoQINGuAALshlpuhl+.pscsupsuhshsshlpSLP+FsGEQllpRE+pLAplQsLALKEhLKR+ctsppssulsssELKuLLsLTREpaLchaDosLPcus..phtphpsshhlscsosssSspSstMcsNshEWPERpVLQNLENhEKhKQKhRsuhL.stSSEQLLG+KDG.R-ShTLLDAKELLKaFTs-GLPlG-LQPLplpRG..-sAF	................s.cVFHYYGPALEFVQMlpLSDLPShahS...DhEFEL.........sLo.ppss+tpShLLL-QlSSLpGKVGALFsLsColSslhlPsss.Q..LSS+KW+EYlA+KPKoI.sVPDVEVKGEpuuYYLLlQGsustt...CKATLlHSAsQINGuh..ALshlpG+h+.ps..ppuchu..hshc..lhSLPpFoGEQllpRE+pLA..pl..QsLALKEhLKR++hupQPps...lSssELKoLLhLTREpFLcha..-uhlPcss.....hp.hsph.ps..shlss..hs.ssp..sssSshhEsNs..LEWPERpVLQNLEshEKsKQKhRsu.......L.s+SSEQLLGHK-G.R..-ShTLLDAKELLKaFTsDGLPlGD.LQPL.lQ+G-psF.........................	0	3	5	13
+14771	PF14920	MTBP_C		MDM2-binding	Coggill P	pcc	Jackhmmer:Q96DY7	Family	MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle [1]. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner [2]. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells [2]. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4) [3]. It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14919.	28.40	28.40	30.40	32.10	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.59	0.70	-4.89	7	57	2012-06-15 13:45:35	2012-06-15 14:45:35	1	5	42	0	33	45	0	234.50	59	31.44	NEW	P-LoPcKL+tLPFEKAutC+YHGIEYCLDsRKALERDsGFuELQSRLIRYETQoTCsR-ssPlPh.......sLSPLPSPAVLSEPtSVPDGEuLQsElRs-sscLKRRS+DhssLhPtKRlsKScSSDSLlStsSssoupa.hshsoRp.puERshSs.............t.tlstpsuuuppssppocoopstKESRSQKHsRhLKEVVucTLpKHGIspcHtCFsuCSQRLF-ISKFYLKDLKTSRGLh-EMKKsAsNNVh.QVI	.............................P-LSPtKLpsLPFEKAusCHYHGlEYCLDsRKALERDsGFuELQSRLIRYETQTTCT..+EshPlPh.......lLSPLPSPAV....hSEPGSVPDGEsLQsEh.......+...sEsuRLKRRS+Dlssl..a.P...pK.RLsKSESSDSLlSQsSGsos....pptthsssR+.psER.Shuss.....s.ts.....pss+hspps.uuup+ssppscs......s+phKESR...SQKHTRhLKE.....VVscTL+KHuIsE...sHcCFsACSQRLFEISKFYLKDLKTSRGLaEEMKKsAssNsh.QVI.............	0	8	10	17
+14772	PF14921	APCDDC		Adenomatosis polyposis coli down-regulated 1	Coggill P	pcc	Jackhmmer:Q8NCL9	Domain	The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo [1]. APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region.  The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling [2].	27.00	27.00	31.60	30.40	25.90	26.40	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.74	0.70	-5.02	11	205	2012-06-15 15:05:53	2012-06-15 16:05:53	1	3	56	0	131	192	0	199.50	39	81.35	NEW	pCpp.hpclppts+lT.s.shPPcLcGpWlSppCEVRPGPEFLTRsYpFa..sNppF+AhQaYYsD.uCppPoaoLlI+Gpl+LRpuSWlspGATEA-aaLc+VsIl.HSppshp+lspclNpoCss.....h.s.spsWhPhh.YpLh....stpsppc............................ChsAhGFuhpELpLlRlppphhhps.........phspELaLGDIHTshspRtpYRPTuYQ.PLpsshcp.spsCPsCullh+uoEppPPlLPs	....................................s.tLpGpWVSptCE...VRPu........s.....FLTRpapFa.....s.N.p.oacua.aaYuDstCpp.PTaTlhs+G+hph..t.psShhlpGGTEhsaclp+spVssh.spsssphLsh.h.sp.oCuu.........tssWt.Gst.-lh...psp...t................................Ch.t.ulphs..hpEhpLh+hEpc...hhtp..................LalGph.TD.so..p..R...p..hRPTS...YQ.PL.ps............................s.............................................	0	27	35	74
+14773	PF14922	FWWh		Protein of unknown function	Coggill P	pcc	Jackhmmer:Q5TG08	Family	This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.	25.00	25.00	28.80	28.80	23.40	21.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.90	0.71	-4.74	18	109	2012-06-15 15:39:53	2012-06-15 16:39:53	1	3	49	0	68	108	1	146.90	32	28.93	NEW	l-htshsshcsschssLP...tplchpplhsplhcutph.tth.......................tt.ap.....................phh...Sct.tulhhDoFWahahctap.c...................p.phps+LFsRlApsYVplhhslt.sch+Dtahpha.phlApslahshhpsFPpuhphasps..F+tpLhphhhhhhoGlps..p.hphscWs	...........................................................................................................................hphstaptpc.stLP...ptlphpphh..llcupp...ph........................c.hc.....................pah...S.tshAlhhDoFWWhFhccapPs..................................................................................................c.QspLFcRIupsYstLhhph..s..sph.....c-...s.hhchhsshLupAlYssFppsFPpSh....Fssc..FKpslssph.hWho.GhhP..p.t.appW.........................	0	35	37	46
+14774	PF14923	CCDC142		Coiled-coil protein 142	Coggill P	pcc	Jackhmmer:Q17RM4	Family	The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.	25.00	25.00	31.60	31.00	23.70	22.20	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.52	0.70	-6.17	6	80	2012-06-15 16:15:37	2012-06-15 17:15:37	1	2	63	0	52	76	0	357.80	33	57.08	NEW	hLWsthGtuLsphh.............sslslas.shshslhphLppshspssLPppsppsLpsls+sLpppushpsWDpuFCtsLGSuspspsl.........th..sshuotTspLltpLF.PLlslLp......p..............sp.RspLhLphP.....LsRhlsTLpooplWlho+sppaLuuWuhspFLLllQ+DL.sLLc.......sscsLshLsps.......tshshslhspLstElp+hhscLptloccslplFot-C+KhoTphFp.sMPpG+aWR+chps-lPspPSpYAthsVppVLtPVlcGlptL.spAphsALopAloAhh-AWL-HILpccI+FSlpGAlQLppDFusVR-hlpuEp.uLStEh+QpLLSLclF+plDGAlhhLLpQPhsKptlscps....+pstsspsQshpplsoSS.LsSLcuh..psshpssl.ssp...s.................us..-.YhluNQQtWL	......................................................................................................................hWs.hu..L-..................lshh..pp.pthtp.L..p..s..splPp.s.ppLtsls.ctLhtpsh.htWDQh.Fp.ALsSu..tsps....................................s....so.Tsp..lh.p....lFssLlsh........................psp.slh..p.Ph....lthh.polposhLWhhtcupphhssWs.spFhhllppDl....hLp..........phpsLp.htpp...............lsltlcppLshElpp.hsplphhscEslp..lhup.C+p.uhtsFphhhPpupaWRhpltsp..stsS.Ysshslcpll.PVlpuhp......phshLs.hLphhhtAWLDHIhp+..tI+FSlpGAlQLhpDFssVRphlpp.phsLo.-l+ppLh.hplhpph-GshhhLLppP.st.plppp........pts.ptthp..p..thsst....s.............................................................................................................	0	15	18	35
+14775	PF14924	DUF4497		Protein of unknown function (DUF4497)	Coggill P	pcc	Jackhmmer:Q9P2G4	Family	This domain family is found in eukaryotes, and is typically between 107 and 123 amino acids in length. There are two completely conserved G residues that may be functionally important.	23.00	23.00	23.20	23.90	22.10	22.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.21	0.71	-3.75	29	85	2012-06-15 16:57:50	2012-06-15 17:57:50	1	8	45	0	74	80	0	109.70	25	15.98	NEW	ppsph.pFppGKSCLFshsspslppphpshslph.shhch.s.h.hsss..ph.............lGsstlslsph......htpl..hpp........hp.p..................stu...cshcspasLhs.psp.ps.GplslhlRloshG..psl..lT	.........h..t..tFspGKSCLFphpsssLpptlhphPLth.hlhplsssh.hsss..pl...................lGssslslsst......hppl....htt........ht.p............................................sss.psh+spasLh........s...tsup.ps.GslslhhRLosLGppl.......	0	26	33	60
+14776	PF14925	HPHLAWLY		Domain of unknown function	Coggill P	pcc	Jackhmmer:Q9P2G4	Family	Members of this family carry two distinct, highly conserved sequence motifs, CPPPLYYTHL and HPHLAWLY. The family is found in eukaryotes, and the function is not known. This family lies at the C-terminus of members.	25.00	25.00	38.90	35.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	640	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.98	0.70	-6.53	5	43	2012-06-15 16:58:46	2012-06-15 17:58:46	1	4	29	0	26	37	0	485.50	48	70.18	NEW	CSNuSSsRSVSPPNQEVTELDlETNIFCPPPLYYTHLTQEKsPPsQGKITIEPQINAPEELDGsFhEEcRVNPPTHTssLKHTsSAT+ESPPMLINPPHVQDlGASNQTTDHsQTEQNRINTIRQLPLLNALLVELSLLYNQPVASPTHIHPHLAWLYRTEDKKSPESSAKSTCKSESKKDKLShGGNEKSVSLQYKKNQsENLKKGKYFEKsSGAPPKRVPRGKLLYGLTNTLKLRLKQTNPDMLVVHEKREQYRKMQAQMLGTKLRIPSSKVKlLSFAEQaQKPHQLPKDKCLESDASFAENSDTSKQISGVlDDPSTopETKLKCATE.KTVDCuENRoNNGLLEEIVSPANSIVsE+FTsAsILEGKh..EMKVQSPsVFQQVAVVDRhlVDKEIDDKQVKTTDsDILTsD..ISEK+PSKNSCSESISELKYSDDFTSPCsSEDFsTSEDTSRILQAHDSSPGTENPKHSQaTSKSSETtLSIRKNSSEKSSILSPPFSAGSPVaSaKRFHISKTQDKSLEEASSISTSDLSSSHWTEEKENQIDQNSMHNSKVIKRDQ..DISlK.KTRTGCKSSEKSQSPRTSQVSSYLPSNLSELELNVLDSSTSDHFEEssDDlGSLNISKQCKDICELVINKLPGYT	........................Cssu.s.pslSs.spEVTELDhETNhhCPPPLYYTpLopEK.ss..spsphTh.sQhN.sE-h-sh..EpphlssPh..ps.ctspssspEpPshL.s.P.phps.utsspss...QsEQstlssIRQLPLLNALLlELSLLhsQPhsoP..splHPHLAWLYRs..E...D..pcu.P-sSsKuTspoEo.psKhshttpcK..sls.Qh+Ksph.p.s.pcs+a.EKpuus..p+Vs+t+LLYGLTNTL+LRLKpTNPsMLlVHEKRE.YRKhQsQhl.Gs.KhRlPSSKsKlhS..A.cQp.Qhs..QLPcDc.l.-ucushsEso-TStQlSssh-csSsocE.sch.p.h.shc.cplc.scs+hssh.lct..hsshtslhs...Ec.h.sshhtt.ph....ch+lpSPsl.tp.shlDp.hls..ct.hs.cplKsht.-..hus..hu-.p+.s.upsSs.EslSELpYSDDh.....s..S..P...CYSEDFsosEsou+....hpAhDSSst.....sE..sspps..phs..sKSS-splSh+csoS-.pSSlLoP..PF...SAGSPVpSh++.+l.Kt.pcpSLEEsSs.lS....sSDh........SS.pWTppKE....sph........Dpsuhpp....Sclh+psp....D.ss..psp.sshKS.EKSQS.pTSQVSSYLPSNlSEL-LsslDs..SsuschpE.pDplGSLsIocQCKDICELVINKLPGYT...................................................................	0	1	2	6
+14777	PF14926	DUF4498		Domain of unknown function (DUF4498)	Eberhardt R	re3	Jackhmmer:Q9BRQ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 308 amino acids in length.	27.00	27.00	28.20	28.20	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.66	0.70	-5.23	16	119	2012-06-18 07:58:32	2012-06-18 08:58:32	1	3	86	0	74	116	1	184.50	36	75.31	NEW	sFs.LstpsFstl..pD+-lpchL.hKWulpsplphpsFpacpp...ap.shppschltsFFpDpsVtpsLpl.p.pssthst.lutp......ssclcsp.lssohhShsFFD+Lhs..su...IVR.psGc.Is+ChD-hh-sh.lSDELRchLL.EDSEpYclFS-s-RpEhLFcLFcpLlLG.GslCQaEDplpPYl-soKplYK-LVulpKsspT.cpIpls.StVa+Vsuh.s.pss..sh...ps....ssHtQshsYlllDPt+RclpllYH	................................................sh.t.phphptFtasp......................ap..hptpphhhsFFpcssVh.pLthh......ts..h....s.t.........stplph..lsso.hohshFppLhs....tsll+.tsGp.lhpChcp.h.tsh.hsDpLRphLL..........p..-S-papl.aop.-RpEFLFplFp+LslG.GslCQaEDslsPYL-ssKhlYKcL......Vu.......lp+ssps......p.......plt...............l..o.lhcV.sh........s.t.t..h....tt..........t.p.tshsahhlss.p+.h.hh.p........................................	0	28	36	55
+14778	PF14927	Neurensin		Neurensin	Eberhardt R	re3	Jackhmmer:Q8IZ57	Family	The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2 [1]. Neurensin-1 plays a role in neurite extension [2].	25.00	25.00	25.50	25.80	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.80	14	169	2012-06-18 09:29:10	2012-06-18 10:29:10	1	2	52	0	110	147	0	131.00	32	57.78	NEW	haGVRuYLHpFY-..........-Cs.......suh.cppc....sh...hphssp+hsulhWKV.......ulssGhLlLlhGlssLhlGYh......lP.+hEhh.....s...............p.uph.hlDspAspaNpsLDsh+LsGssLhClGGlhlAhsLl..lsshtps.tcpE.hhpts.ppt.	.................................................................................................................hch...................uhlSuhlFLlhGlhllsluYh......VP.clcs......s....................p.t-h...hl-p...pu...s...phsutLDpChlAGhsLhslGGhlLushLh..hSha..ttp...............h....................	0	15	24	50
+14779	PF14928	S_tail_recep_bd		Short tail fibre protein receptor-binding domain	Eberhardt R	re3	CATH:1ocy_A_02	Domain	This domain is a receptor binding domain found on bacteriophage short tail fibre proteins. It contains a zinc-binding site and a potential lipopolysaccharide-binding site [1].	27.00	27.00	31.40	42.40	22.50	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.50	0.71	-3.90	9	26	2012-06-18 10:30:31	2012-06-18 11:30:31	1	5	24	2	0	30	0	119.20	54	23.35	NEW	ssstcIh..ss+GsDuKsKPtLGsGsuGhslGpVQtQQlphHKHAuGaGE...psssusFGsTspssalGoppt.DWDNtpYFTN-GaEl-us.pRsshsTLNocsLIGsEsRPWsMSl.aIIKV	.................ssGsHIh..ss+GpDuhGKsRLGsGCsGhhVGpVQsQQhpYHKHAGGaGE...pcspu...sFGsTstssYlGTRKthDWDNtSYFTNDGaE....lsss..RsuhsTLNpEGLIGsETRPWNhSLNYIIKV.	0	0	0	0
+14780	PF14929	TAF1_subA		TAF RNA Polymerase I subunit A	Coggill P, Hetherington K	kh6	Jackhmmer: Q15573	Family	TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilises nucleolar transcription factor 1/UBTF on rDNA.	27.00	27.00	28.30	27.60	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	547	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.85	0.70	-6.06	13	157	2012-06-18 12:06:50	2012-06-18 13:06:50	1	5	65	0	85	134	0	250.30	21	84.78	NEW	chpsst-tpshpssstppchhhphhhshpt.shh...........pcs+hhplLpchlpp+pWspAushhpshlcsht+s.shpt..sc.hh.tlts-llhphsps.......huschpshuthhslhhpp..............h.....p.phhlhLppuLahlppsthttsshphoh......h.ppp.t.shpslhphahGLltYcpWhpsl.cph+hccpsh................phtts.hsppst....pps..........hspphspsshtsssspsslhphsts..................lDphlps.spthpFhpspcthcpsho.hs..E+hssss..t.h..............................................shaphl.+aL..+....uss.s........................hhlhutclp-t...hpp.s.sstssh.hchtshhhp.hs...ps.sshlhSslcchhphsPspphhl-+tphh+cp....hpphh-h...+hp.h.sp..hW..hs.sh.p.htphtp.tEcpppuhplhF.hLDauss+pN.pAWphhtphlpplhh.....saltppWcsRpsWW.saHFSp.h....h.p.......tts...chhspKAssAuhhhG.thtYh........p...hp.h.hLtcphpp.....p+lhpsh	..............................................................................................................t...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tt........................................	0	12	24	48
+14781	PF14930	Qn_am_d_aII		Quinohemoprotein amine dehydrogenase, alpha subunit domain II	Eberhardt R	re3	CATH:1pby_A_02	Domain	This is the second domain of the alpha subunit of quinohemoprotein amine dehydrogenase [1,2]	27.00	27.00	57.60	56.70	26.00	19.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.41	0.72	-4.10	20	36	2012-06-18 12:07:57	2012-06-18 13:07:57	1	4	31	4	13	43	1	108.10	38	20.58	NEW	tsssLsGpWsluG+hPG+G-apGsMolsuuut.DpYsVshsh+.aADGsshsupGsAllYTGYEWRAslslG...........ssshRQVhAhs..ssphpGRhF.tspDchGuchhAs+ss	..p.ssLsGpWshoG+hPu+G-hpGsMolssuss.DsYpVplchc.aADGsshsupGsAllYsGYEWRuslclG..........ssshRQVhAhp..suphpGRhF-sscDEhGhchpAs+t........	0	2	9	10
+14782	PF14931	IFT20		Intraflagellar transport complex B, subunit 20	Coggill P	pcc	Jackhmmer:Q8IY31	Family	IFT20 is subunit 20 of the intraflagellar transport complex B [1]. The intraflagellar transport complex assembles and maintains eukaryotic cilia and flagella. IFT20 is localised to the Golgi complex and is anchored there by the Golgi polypeptide, GMAP210, whereas all other subunits except IFT172 localise to cilia and the peri-basal body or centrosomal region at the base of cilia [1,2,3].  IFT20 accompanies Golgi-derived vesicles to the point of exocytosis near the basal bodies where the other IFT polypeptides are present, and where the intact IFT particle is assembled in association with the inner surface of the cell membrane.  Passage of the IFT complex then follows, through the flagellar pore recognition site at the transition region, into the ciliary compartment.  There also appears to be a role of intraflagellar transport (IFT) polypeptides in the formation of the immune synapse in non ciliated cells. The flagellum, in addition to being a sensory and motile organelle, is also a secretory organelle [5]. A number of IFT components are expressed in haematopoietic cells, which have no cilia, indicating an unexpected role of IFT proteins in immune synapse-assembly and intracellular membrane trafficking in T lymphocytes; this suggests that the immune synapse could represent the functional homologue of the primary cilium in these cells [6,7].	27.00	27.00	27.90	28.70	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.40	0.71	-4.21	26	146	2012-06-18 12:46:22	2012-06-18 13:46:22	1	2	119	0	100	147	2	114.40	42	85.21	NEW	tGlahD-hs+lRVl-P-htspoppL+-EspcFlc+lspFpcllpphhphlcphA+cVEpEKl+AIGsRNhlcoh.scpRcscpQplQshItEKpsELERLpsEacuLp+lEpEQpphIpph	........GlaFD..-ls+lRVLDP..............-ssppT.cLK-ECccFlcKls...pFp+lVsshlcll-plAKc...sEsEKhKAIGsRNhLcSh.ucpRcsppQplQshItEKphpLERh+sEY-uLpKlEtEQpEhIpph...............	0	40	50	77
+14783	PF14932	HAUS-augmin3		HAUS augmin-like complex subunit 3	Coggill P	pcc	Jackhmmer:Q8IY31	Family	This domain is subunit three of the augmin complex found from Drosophila to humans [1]. The HAUS-augmin complex is made up of eight subunits.\	  The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity [2].	27.00	27.00	29.70	29.30	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.64	0.70	-5.20	25	132	2012-06-18 13:04:39	2012-06-18 14:04:39	1	2	88	0	88	120	0	228.30	27	43.67	NEW	Wlh.ps.-phcpFhcWlspsls-sNlLo-p-Lppa-pLp.ppGc.lLcup-L-.sLpplpspsssh....ph......s..-......p-lctLcppltsl.tchpp.htpLh.schp.phcph.hspph...spLpspp...tcsstthptspph..ltsphpc+sppLpplp.pcssphsp-hpc.tp....ps.sslFlpQhslcpYhhps-phhphLshYh++pFpht.hchs..psssps....lp.......t....c.pc..th.ppp...ptELppLpptht.hsphpaIctcscs.p	..................................WhF.ps..-scsFLcWhCssls.ppNlLotpElpta.ppLp....cpG+.l.....L....-utsL-tsLcs......hps.s.ph.......ph...............p..-........................ppl-tLcpplpsl.tchpphphphh.pchp..hsph..tupp.....hplpscp......tpsstphppstth.......lps..sphspplptlhsplsphh......t...............h............pp......t.s...................pp...ssl...aluphsLcpYltp--p.ottLs.ahpKpFhpG.tchs..Essspppa......hD.hpt..hp.........cppc...hpcc....phEhtRL...p.ha.........h.huppphIphpsp...........................................	0	22	36	61
+14784	PF14933	CEP19		CEP19-like protein	Coggill P, Hetherington K	kh6	Jackhmmer:Q96LK0	Family	This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organise the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase [1].	27.00	27.00	27.00	28.50	25.00	26.50	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.02	0.71	-3.94	20	94	2012-06-18 14:37:52	2012-06-18 15:37:52	1	4	74	0	64	86	0	149.40	38	67.25	NEW	++sGlRhpPPslllhYpsp....ssKhRpRh....lPl.Rshppposssths-cLtpp.......s++psaLpplsphQlc.........+hhphL.........................psphpuhshspshpthtpctsls................pcDLNKlDDppLpctKstM-ctFc+Npl+PGDssFlYDhcl-Fspsc..psSuWD	....................................................................++sGl+hpPPslllhYppp....ps+.RpRh....hPl.pshpp.Sss...sphAEpL+ps.......s+H+sYL..pplshtQlc.........+lhphL...............................................................................................pshhpGpolspshpphppctsl-..................s-cDLNKLDDcELt+pKshMDEhFc+Nph+.sDPsFVYDlEl-Fspsp...pssuWD................................	0	32	38	48
+14785	PF14934	DUF4499		Domain of unknown function (DUF4499)	Coggill P, Hetherington K	kh6	Jackhmmer:Q8TBM7	Family	This family contains a protein found in eukaryotes. Transmembrane protein C10orf57 is encoded for by the gene chromosome 10 open reading frame 57 (C10orf57) located in chromosomal position 10q22.3. The exact function of this protein is still unknown, however it is thought to be an integral membrane protein. The protein sequence is 123 amino acids in length and has a mass of approximately 14.2 kDa.  The family also includes some longer proteins that possess an N-terminal dehydrogenase domain, Pfam:PF01073.	21.90	21.90	22.60	24.90	21.80	20.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.06	0.72	-4.04	28	133	2012-06-18 14:45:52	2012-06-18 15:45:52	1	4	93	0	76	130	1	88.90	31	42.66	NEW	luhshahhslFtsstlPht.lGPluhh...hchhlhpphpllphsahhAhllHlsEAlYAhhLs+ptsl.csssphtWFlQThlhGasSLplLlc	.................................................h..hshhhhslFhst.lP...lGPlu.h...sphl.l.p.phpllp.hsahlAhllHl.sEulYAhhLC+cp.sl.sspsphhWFlQTFlhGhsSLslLl.t........	0	30	43	54
+14786	PF14935	TMEM138		Transmembrane protein 138	Coggill P, Hetherington L	kh6	Jackhmmer:Q9NPI0	Family	This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells [1]. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.	27.00	27.00	31.60	31.60	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.53	0.71	-3.78	16	91	2012-06-18 14:53:30	2012-06-18 15:53:30	1	1	76	0	59	79	0	117.90	48	73.53	NEW	stllLFllQDssIlhshlllhLshauTaVaQsGhsplLlc+F+hhlllsslYFhLSluhHhWlls.hRh..tssspa.Ws.pGLhALaVlQRlsSVhYYYhYKRTALphuDPRaYc-pl.Wlpcph	.................lQLVLFIIQDlsllhslIllhLhhFsT...aVFQuGLlsLLh++F+ssllloslYhsLSIulHsWlhs.lRW.....pssspalWT....cG.LpsLFVhQR...l....uAVlYaYhYKRTAlpluDPRFY.pDSh.WLRcpa......	0	14	19	40
+14787	PF14936	p53-inducible11		Tumour protein p53-inducible protein 11	Coggill P, Hetherington K	kh6	Jackhmmer:O14683	Family	TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis [1]. The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation [1].	27.00	27.00	37.90	37.60	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.27	0.71	-4.33	6	94	2012-06-18 15:01:03	2012-06-18 16:01:03	1	2	50	0	42	69	0	143.60	62	78.27	NEW	MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQlLGNEIKFAVREPlGLRlW.hl...SAslFTulAlMALsFPsQLY-sVF-pt.s......oo+lSlRLYGGALLSlSLIhWNuLYTuEKVIIpWTLLoEACYFulQhLVTolT.LlEhGhhu.us.llLLluRlLFlhlolsYYYhLGR+PKK	..............MKKHSQTDLVSRLKTRKILGVGG.E.DDDGEVHRSKISQVLG..NEI....K.....FsV.REPLGLRVWQFl...SAVlFou.lAlMALsFPD..Q..LY-sVF-tups......sSc.ssl.RLYGGALLuluLlhWssLhssE.+s.IphsLLspAsaaulQhlV..................................................................................................	0	8	11	24
+14788	PF14937	DUF4500		Domain of unknown function (DUF4500)	Coggill P, Hetherington K	kh6	Jackhmmer:Q96KF7	Family	This family is found in eukaryotes. The function of this protein remains unknown. The gene which encodes for this protein is named chromosome 6 open reading frame 162 (C6orf162) and is found between the chromosomal positions 6q15-q16.1. It is thought that this protein may be an important part of membrane function.	27.00	27.00	28.20	28.10	23.50	22.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.05	0.72	-4.15	16	85	2012-06-18 15:12:04	2012-06-18 16:12:04	1	2	73	0	57	80	0	83.80	51	80.74	NEW	ppsps.t...htusGlRSl+TToLFRAlN.ELalKPNKslMuhGLlAlohCsGYluYM+sph-spp...hYsAlcuDGpc.hh..+KpS+W	..........h.....pcpshtssGLRusRTToLFRAVNPELFlKPNKsVMAFGLlsloLCVuYIuYhHAppENcp..pLYEAlcS-GcphhR..RKoSKW.....................................	0	13	18	35
+14789	PF14938	SNAP		Soluble NSF attachment protein, SNAP	Eberhardt R	re3	CATH:1qqe_A_00	Domain	The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus [1]. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor) [2]. They are structurally similar to TPR repeats [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.82	0.70	-5.26	62	864	2012-10-11 20:01:04	2012-06-18 16:23:28	1	81	388	5	519	1551	81	229.00	25	66.89	NEW	scupplhtc.A-KKlpsstuhh.uhF..Gupp.KaE-Au-LappAANtaKlsKpaccAGpsah+uAcsphc.hsspc-AAssas-AucsaKKs........ssp..cAlpsLppAlph.asctG+appAAcappclAElYEp-........tD...........hcpAlcs..YcpAu-aaps-p.usutANpChlKlA.pl.uAphp..pY.cAl-laEclAcpSlsNsLhKaSlKcYaLpAuLCpLsts.DsVusppuLp+YpchDPoFssoREt+hLtsLlpAh-ptDs-tFosslh-aDpho+LDpWKTolLL+lKpslp	.....................................................................t....th.tp.Ac+hhp........th.h...................chcpAsphatpA.As.ha....+...h......t..+p........hppAs.psa...hcs.A.p...hp.....p....hp...s....................c...A...A.......p.s.h..h...p.Au......p..s.h.+ch.................s..p...................cA.l.p.h..l...pp.Al....ph...Y...t.....c....h...G...p...h.p.h....A...Ap.th...........t.plAc...........lhE.s....p......................c...................hccAlp.h..Ypp.Au..-....h....a...p..t...-p.......pp....t.......t...A.s........c...hhh....+...sA............p...h...hs.p.h...p.................pY.pcA.h.ph.a.c...p.......h......tt.......h...p.p...h...h....p.....h..s..h.+..t......hhhtt.hl.s...hh.......h..................D.........h.....ts........p.shp.ph...t.....tF..t.oc-ht.h.httl.htuhc........pts......................pthtphh......................................................................................	0	197	301	426
+14790	PF14939	DCAF15_WD40	ShortName;	DDB1-and CUL4-substrate receptor 15, WD repeat	Coggill P	pcc	Jackhmmer:Q66K64	Repeat	DCAFs, Ddb1- and Cul4-associated factors, are substrate receptors for the Cul4-Ddb1 Ubiquitin Ligase. There are 18 different factors, the majority of which are WD40-repeat-proteins [1].	23.90	21.80	26.50	23.10	23.70	21.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.46	0.70	-4.98	11	84	2012-06-18 15:44:06	2012-06-18 16:44:06	1	3	69	0	57	80	0	186.10	44	29.51	NEW	stppptphFp+.lPs+lplsLKslls.s..LhsGHlFLGhTKCGQaLLSYoh.h-h-ss.h.....sshY+YcLaWWpFpP...........+ppLpKltpVpLFs-c..tlsstLplslspW..sDpppllVaG..hp...........susc-spcsYlTlssVPsls.Cp-C+plssu.............ssh.hp.....CLcHshTlHopYpllsPaPsFpPplsLppsshlllNoushlhsLplplshsc	...................................u.tphp.phFc+.lPsRlplsLKsllsps...LhtGHIFhGFopCGpYlLSYssssssss...........shYhYpLYaWtFps...........+p+L+hltpVRLFpDc............tl.splhlo...lspW..sDtphllVaG...............husEspcDhYlohVsVPs.s.ChtCpchspstsh......................ss..up.......CLpHuahlHTKYpll.PaPsFpPshpLppsphlLlNTuh.lhshtlslcs.st......................................	0	18	22	39
+14791	PF14940	TMEM219		Transmembrane 219	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NWD8	Family	This protein belongs to a family found in eukaryotes.  Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention [1].	27.00	27.00	28.10	30.70	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.37	0.70	-5.25	9	99	2012-06-19 15:03:32	2012-06-19 16:03:32	1	2	50	0	54	95	0	210.30	46	75.39	NEW	L+salspRPPhVlFhlslhshAluhlsLuhah..phptlpsPDhspDWNphLhphuphcFCs.........tpstshphhhs-oss....................hpspsshslolshhLsls.hhs.sGhspNhsh.lpusltGpplGLpGt.utEplNlTFpLsssh....s...sth..sphtTChshoAssplhPsoh.PPpC.spphssssh.p.hhhsh.pp...........hshpsssh+lhps.sPcLTVhl	....L+lhlup+PPLVshhlsl.hhuluhLsLGhFh..+hptl+SP-hspDWNoFLhpFspLcLCs........................ps.s.t..hN-TsT.....................................hc..ppGPhslolhhTLsls.....sG.sR.NhT+.l.uTlhGpQlGLpGppApEplpIThplsssh..................shsTChshoAssslhPso..P.pCss-shuNATL...h...hs.................s.ttthhphh.t.p.hLo.hl.............................	0	11	15	25
+14792	PF14941	OAF		Transcriptional regulator, Out at first	Coggill P, Hetherington K	kh6	Jackhmmer:Q86UD1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes [1]. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response [2].	27.00	27.00	56.30	34.30	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.66	0.70	-5.22	7	85	2012-06-19 15:11:22	2012-06-19 16:11:22	1	3	68	0	59	91	0	210.50	50	81.54	NEW	u-L+VpVRLsDGQVTEEsLpADSscDhIoLEF+psDGTLITalADFKp-VKIFRALILGELERGQSQaQALCFlTRLp+NEIIPSEuMA+LRQKNP+slRpAEEhRGhEphoMslAVNho+uhQLSsHI+NlCuEA+-AlYTRctDV+aWL-+.....Gh-uShFEhhPpsuphssLppCppspDhWpPClCoYsLsLEWYPChLKYC+uRDs..+s...........osYKCGI+SCpKuYpFsaYVPQKQLCLWDE	................................pLhl.Vp..sGplhpEslpus.stD.IoLEhp+sDGTLlo.hhDF+p-VpIh+ALlLGE.E+GQS..QaQshCFlT+hp+s-hIsS-AMAKLRQKNP+slRpAEEs+GhEphpMsshVshopuh.lS.HlpslCAEAh-AhYsRptDl+hWhEp...............us.tus..hEhhPp.s...........p...................RCtp...sushhtPClCphthsluWYPChLKYC+u+s....ts.................osY+CGI+oCpKsapFsaYV.Q+Q.CLWDE.....................................................	0	16	21	40
+14793	PF14942	Muted		Organelle biogenesis, Muted-like protein	Coggill P, Hetherington P	kh6	Jackhmmer:Q8TDH9	Family	The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms.  The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system [1].	26.00	25.70	26.00	25.70	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.90	0.71	-4.32	11	90	2012-06-19 15:23:15	2012-06-19 16:23:15	1	3	76	0	64	85	0	139.90	38	76.07	NEW	llKDlGEIaSRLLDHRPVlQGEI+YFl+EFEEKRuhRElchLEslpphlsEhsEchLP+CppshpspLsplhppLpsAssslp+Lpp+EpcpcK..uspLpsucctRptcWEcFhp-Qpp+ptcVDcEaccthc+lpEQYs-hc+cL	............lh+DlG-IaSRLLDHRPllpGEh+aFlKEFEEKRGhREh+sLcslpphlpEosEphLP+Cpcs....h....p......cpLsp..lhp+L.....psAscslp+Lpp+Epcpcc....sspL.tsccp+ptpW-cFhcc.ppcptclDpEacct.ccLp-pYschphcL.................	0	21	25	44
+14794	PF14943	MRP-S26		Mitochondrial ribosome subunit S26	Eberhardt R	re3	Jackhmmer:Q9BYN8	Family	This family of proteins corresponds to mitochondrial ribosomal subunit S26 in eukaryotes [1]	27.00	27.00	30.40	29.90	26.10	21.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.00	0.71	-4.70	24	113	2012-06-19 15:32:32	2012-06-19 16:32:32	1	6	90	0	71	118	0	151.90	34	68.71	NEW	KPRalPsAKSKhaRVspts.hs.-EhhELpchappY+sthpulRphhp...cEshppphpscssplh.p..cppcE....pEapphhthN-phNtcltchREtRlpcEpEcpcphhhcphhtcppcppphhcptEppVhp.p....EpuKoFITtENLDptIEcALssPssYNaAlDhpGslh	..................................KsRa.PsAKSKhhR.l.h.s.hsstEhh.lhchap..pY+phhpul....Rt.ht...pElhppt.pspss.thh.p.pttpp......pEacplhshNctcNtchtphR.tRlppEtccpcph.hpphttctpctpthhppt-pcVhphp....EcuKsFITtENL-ttIEpALs.s.P.hsYNaAlDhpGph........	0	23	29	52
+14795	PF14944	TCRP1		Tongue Cancer Chemotherapy Resistant Protein 1	Coggill P, Hetherington K	kh6	Jackhmmer:A1KXE4	Family	This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length [1].	27.00	27.00	109.60	30.10	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.01	0.71	-11.41	0.71	-4.37	3	109	2012-06-19 15:33:00	2012-06-19 16:33:00	1	2	39	0	56	76	0	203.30	71	99.36	NEW	MNPVYSPuSoGVPYuNsKGMGYPAGFPsGYAAAAPAYoPNMYAGuNPAFs..........................P..........................................GYTPGTPYKVSCSPooGTVPPYSSSPNPYQTAVYPlRSAYPQQNPYA.......QQGAYYTQPLYAAPPHVIHHTTVVQPNGMPAAMYPAPIPsPRsNGVAMGMVAGTTMAMSAGTLLTSPpPTPVuPHPVSVPTYRPPGTPTYSYVPPQW	.....................................MNPVYSPspsGsPYuNsKshuYs..GaPhuYsAAAPAYsPshYPsssPoat............................................s................................................................tYT.sGTPYKVsso.osuAsPPYSsSPNPYQTAhYPlRSAYPQQN.YA........QGsYYTQPlYAA.PHVIHHTTVVQPNuhPu.slYPAPl..s..sPRsNGV.sMGMVAGTTMAMSA...GTLLTs.p.TslusHPVohPTYRA.GTPsYSYVPPpW.............................	0	2	7	23
+14796	PF14945	LLC1		Normal lung function maintenance, Low in Lung Cancer 1 protein	Coggill P, Hetherington K	kh6	Jackhmmer:Q9H1P6	Family	This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis [1].	26.10	26.10	26.40	27.30	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.69	0.71	-3.79	8	54	2012-06-19 16:02:06	2012-06-19 17:02:06	1	2	41	0	42	55	0	111.30	41	84.16	NEW	hVapDEIaKDHl++EptApKpWspcWGaLp..sphcclt-cpcchpss+s+lshtpcphhppLPPhcs.ht......tsuPPVPpTTuGhIGWRSupPphNLEhYt+aspstpsKGull+cLpWPpEG	.............................hVspDEI.WKh+l+sEpcAppsWsppWGFLs....sshcE.Llcpc.cc....s.sKPKlcLPp+......hplcPloPl-KYIKl.........hPSP.PVPpTTQGFIGWRSulPths.cphc+ptchtpCKGuas+cLpWPcpG............................................................	0	19	19	24
+14797	PF14946	DUF4501		Domain of unknown function (DUF4501)	Coggill P, Hetherington K	kh6	Jackhmmer:Q96HA4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 167 and 308 amino acids in length. The exact function of this protein remains unknown, but it is thought to be a single-pass membrane protein. This family contains many highly conserved cysteine residues.	26.50	26.50	53.90	26.50	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.12	0.71	-4.79	9	65	2012-06-20 08:49:22	2012-06-20 09:49:22	1	2	30	0	24	54	0	129.60	50	72.75	NEW	SotStuQpPECCsDss-lNuoCsGouLCGPGCYR+WstDGSuSCV+CtNGT.....shaNsSECRshuGRGhphPhN+SoGsPG..phGGPpVAASLFLGThFISoGLILSVAuFFYLKRSSKLPcVFYRRN+APlLQPGEsAuMIPsPQSSVRKPRYVRRERs.-psssPushSosEARlSNV	.............................................sp.sECCs-hhshNsoCsssshCuPGCat+htt-us.sClpC.sts..............................s.st.h.su.Gh.hshNpSossss....p.Gu.PpV.AASLhLGThFIS.hLILSVAuFFYLKRo..sKLPcl.h.YpRsKAssLQPuEsAuMIPs..PpS.SlRKPRYlR+-p.......................................	0	2	3	9
+14798	PF14947	HTH_45		Winged helix-turn-helix	Eberhardt R	re3	CATH:1r7j_A_00	Domain	This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerisation of this domain [1].	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.45	0.72	-4.16	27	290	2012-10-04 14:01:12	2012-06-20 10:24:33	1	6	113	3	147	420	77	75.80	24	67.77	NEW	+Ro+h-IIh-ILcsh..pusspKT+IhYpANLsachhpcYlshLhcpGl...I....pp.ssspYplT-KGpclLcphcchhchhp	......................................pl.hhcILph..h.......p.......sstp....h...T..cl.....h..hps.s.....L.sapp....hp+Y.lphLhcpGL...l.......................pp..psp.....p....Y.p..l.TcKG.p.c.hL.c.p.h.cph.p...t.......................	0	48	87	120
+14799	PF14948	RESP18		RESP18 domain	Eberhardt R	re3	Jackhmmer:Q5W5W9	Family	This domain is found in the glucocorticoid-responsive protein regulated endocrine-specific protein 18 (RESP18) and in the N-terminal extracellular region of receptor-type tyrosine-protein phosphatases containing the protein-tyrosine phosphatase receptor IA-2 domain (Pfam:PF11548) [1,2].	25.00	25.00	25.40	27.50	21.50	24.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.31	0.72	-3.98	6	113	2012-06-20 10:28:28	2012-06-20 11:28:28	1	3	36	0	39	121	0	96.30	40	14.55	NEW	GQuQVGVGQhWPL.GhsTPVFQ+LQsVLQQIsPpGLFWKDDhTQcVMoQKMt+IS+LHPp-P.....CsRsspAusPT+TstshuKQEEKLpLLhP...tpSPhVKVNR-pC	.............GQsQsussQhhshhpVosPVLQ+LQs.VLpQLh...sQG...LoW+D.DlTQaVloQEME+lPR..L.+..P...-P.....ps+DtpulsPp+s....s.ttp......P.............................................................................	0	3	5	11
+14800	PF14949	ARF7EP_C		ARF7 effector protein C-terminus	Eberhardt R	re3	Jackhmmer:Q8N8R7	Family	This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells [1]. It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.	27.00	27.00	33.40	33.40	19.50	20.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.15	0.72	-10.99	0.72	-3.61	25	126	2012-06-20 11:48:40	2012-06-20 12:48:40	1	4	78	0	92	118	0	103.30	45	54.39	NEW	csp+pLcpLthpsssp.hl.....ssFsPpsopRcKR+h...scp.p......shsccsplYDcpGhLhpsu...t...DLCDCL-h-CsGCaaPCscCuSsKCGscCRsNRKWhY-plEh-u	....................................................................p.t+tL+sLtFpNPG.ps........-.Fs....Pcs...t.p....RcKRth..hpphs..................hpsh..tps+hYDppGhLltss......h......DLCDCL-c-ChGCFYPCPpCsSsKCGsECRCsRKWlY-pIchEu.......	0	20	26	51
+14801	PF14950	DUF4502		Domain of unknown function (DUF4502)	Eberhardt R	re3	Jackhmmer:Q14159	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.	27.00	27.00	37.90	37.30	26.10	23.90	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.31	0.70	-5.29	4	71	2012-06-20 15:14:56	2012-06-20 16:14:56	1	5	36	0	34	68	0	196.00	42	38.14	NEW	KRKRshchEpPSFPsEps.phRRuGh+TstsusSLScAWLRCGEGF.coush.SL.TuEKKohTEKHLELss+PKpE.TTSK..uTStLssIsWSSStSDhSDEDKThs..........phQR.........................D-LQhIDWElDSD+t-ss-sD.EhE--c.sl-ISDCsSsA...SLTs--p.sE.PcssssEILEYSSDSEc--DsEpsLhIDSESsHKYcssFtSDuR.lh.p.hs.cscSsEsILpTPQK.Ts.....KhPKTPEsSuK+.KKLLRGGLAERLNtLQNRcRSAISLWRHQClSYQpT.uGcKSGVLTVKILELHEECuMQVAhCEQLst..hsusstuhA..sGAsLKVLFTKETAspLpG+PQDlV+IaPPWQKL	...........................................................................................................................................................................................................................................................................................................................................................................................................................hplshC.c.h..........ssts...........ts.lhVLFo+ETsthL.s.tPtDhlhIaPPWp.............	0	5	7	14
+14802	PF14951	DUF4503		Domain of unknown function (DUF4503)	Eberhardt R	re3	Jackhmmer:Q14159	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.	27.00	27.00	122.80	61.50	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.32	0.70	-6.32	4	70	2012-06-20 15:23:30	2012-06-20 16:23:30	1	4	36	0	29	74	0	325.50	56	58.67	NEW	QDAhGMFuEVHLpushhK.......u+QLEGKSCSLsGMKVLQKsTRGRTsGLFSLIDoLWPPllPLKsPGpuQsspplcTaLPPPuFCYILoAHPslGQIDhI-tD.IsKLYQPPVsRsLR-IlQhN-hSTRCSFYApVIYQ+PQLpSLL..tQ+EIWLhVTDlTLQhp-EpssuLPKTLsVhlAPSCVLusEVlEALsstssauLLF+DAlR-pGRIVClERTVLLlQKPLLussSuspSC-LsuPVpLD-LDusT.VNSICSVQGTVVGVDESTAFSWPVCDhCGNsRLEQpPEDRGsFSCGDCSplVoSPll+RHLpVFLDCsSRPpCTV+VKL.QpSIS.LLRhAAuEDGSYEVcSVLGKEVG.LNCFVQSlTop.uSC.VsLEEIELLSAs	..............QDuhGhFuEVpLph..sh.p.......s+phEG+oCpLsGhKVLQ+sTRGRssGlFSLIDoLWPPshPLKs......PGps.Qs.s.cEh+sp...LP...PPuhCYlLoApss.upl-lh-...............t-sIspLYpPPss+sL+-ILQhssh.u.sRCSFaApVIYQR...PQLp.ull.lp.QREIWLlVTDsTLQhp-EpcspLP..KTL.VhVus.CVLssEVlEALssuus+slhFKDALR-p.GR.IlC.sERTVLLL..QKPl..LsssSu..........ApssE...LssPVh...........LDpLDSsT.VNSICSVQG..sVVGVDEsTAFSWPVCshCGNu+LEppPc..c.pGsFpCupCuplVsSPlh+hpLpVFLsC.SpPps.pVKVKLhQpo.ISSLLt.uAt.E...D...GsYEVcsVLGpcVG.L.saVpuhotp.s.h.hsLEElpL...........................................	0	4	5	13
+14803	PF14952	zf-tcix		Putative treble-clef, zinc-finger, Zn-binding	Coggill P	pcc	Jackhmmer:Q9NWW7	Domain	This domain resembles the zinc-binding domain of prokaryotic topoisomerases, family DNA_ligase_ZBD Pfam:PF03119. The function of the eukaryotic proteins it is carried on is not known.	31.20	31.20	31.90	39.20	27.60	31.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.54	0.72	-4.62	12	74	2012-06-20 15:35:29	2012-06-20 16:35:29	1	2	59	0	45	72	0	43.10	65	7.99	NEW	pplu+hTlRGl+KCPcCGshN..GoRuh.CKNcsCstlhpthsstp	.SDLGKATLRGIRKCP+CGTYN..GTRG.LSCKNKsCGslFRhuucK.p...	0	8	11	26
+14804	PF14953	DUF4504		Domain of unknown function (DUF4504)	Eberhardt R	re3	Jackhmmer:Q96LT6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.	25.00	25.00	25.70	25.10	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.71	0.70	-5.10	29	96	2012-06-21 08:33:36	2012-06-21 09:33:36	1	6	77	0	61	96	0	236.90	26	75.63	NEW	stpshhttt+p+hstssshcLss-lLAlspGL+PslLhDhs...usssspLQpaLppL.....Qssuhl......hp.........sL+lh.Ip-.sh...........hllpscthsp+lcpsLhupst.ll.VshppppPslso..p.sslts.ltsllsphp...................................................shppst.ssshssplpsopasLsTl.GhLLGYPVsYh....Fspsput-..pCLohpsL+la..........pshl..sapsspst...t.......p.pLhSFSVPpsL.sthps.h-sWtcphhs+hppp.....ssassLplpspssphsulsL	..........................................................h.......thphp...s.phpLtt-llAVspG.L+PulLhDhs...ss..hsplQphL.ppL.......pshshl...............hp.......sL+l.h.ls-.s............hllssctht.p.a.l...cpshh...up.t...hlpVs.pptpPplhs...p..ps.ltshltp.lhpthp.................................................................................t.pps..hhs..sthpssshsL..sTlhGlLLGYPVsYh...............Fp.spspc.......sCLuhssLcla..........pshh...sh..t..p......................................LhSFSlPtsl..thpp......p.W.pph.tphptp........p.hts..lphp.p.hp..s.............................................................................	1	20	33	46
+14805	PF14954	LIX1		Limb expression 1	Eberhardt R	re3	Jackhmmer:Q8IVB5	Family	This entry represents the limb expression 1 (LIX1) family [1].	27.00	27.00	31.40	31.20	25.90	18.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.57	0.70	-5.40	8	135	2012-06-21 10:00:33	2012-06-21 11:00:33	1	3	70	0	80	111	0	228.70	68	83.86	NEW	c-ulsulspshAcaspGaucVNVVEALQEFWQMKpARGAch+sGALVlYESlPSsuPPYVCYVTLPGGSCFGSFQsCPTKAEARRSAAKIALMNSVFNEHPSRRITD-FIEKAVsEApASF..............pG.sss-s-sPsTGIGAFRFMLEuNKG+TMLEFQELMTVFQLLHWNGSLKAMRERpCSRQEVlAHYSpRuLDD-MRSQMALDWlsREpE...o.PGlLSpELAhAE+ELEpARLAGRELRFPKEKKDIL.LAtuQl	....................p.........s.tp.s.sh.t..c.....lNVVphLQEFW.phKQsR.....G.......As..............h...pstuLVVYE.lPSsuPPYVCYVTLPGGSCFGsFQhCsTKAEARRsAAKlALMNSVFNEhPSRRITcEFIp+SVpEAlASh.....................sG..sh--ADsP.sTuIGAa+aMLESNpGKoMLEFQELMTVFQLLHWNGSLKAhRERpCSRQEVluaYSpRuLD-cMRspMALDWltREpp...s...PGhlupELt.spREL-cARhAGpELRFaKEKK-IL.LAhsQl.....................	0	15	21	43
+14806	PF14955	MRP-S24		Mitochondrial ribosome subunit S24	Eberhardt R	re3	Jackhmmer:Q96EL2	Family	This family of proteins corresponds to mitochondrial ribosomal subunit S24 in eukaryotes [1-2].	25.00	25.00	27.80	27.00	22.60	21.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.58	0.71	-4.33	19	118	2012-06-21 10:09:16	2012-06-21 11:09:16	1	4	92	0	73	109	0	125.70	48	78.56	NEW	tKspuGRa+lo.+ts+PLTYEMAp.PHhIuHRKoWNSWpTuNLcsttp.suEs.........slEDhFIR+FlpGTaHshls...SEllIKRppNhIhIAull..hpplsspKhYFLlGYTEElLShaL+CPVKLElQoVssKpsVlaKYI	......................s.+spuuRh+ls.+ts+PlTYE.ApsPHaIuHRKuW.ShpTuNLcGp.......t+.su-p.........slEDhFlR+FhhGT.a.uhls...sEllIKRptNhlcIsull...hpplss+KhYFLlGYoEpLLSaahKCPV+LELQTVssK..VlaKYl................	0	29	35	54
+14807	PF14956	DUF4505		Domain of unknown function (DUF4505)	Eberhardt R	re3	Jackhmmer:Q6P1X6	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 166 and 225 amino acids in length.	27.00	27.00	43.60	33.10	19.30	22.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.32	0.71	-4.65	12	106	2012-06-21 10:49:48	2012-06-21 11:49:48	1	2	92	\N	71	107	2	161.30	42	81.20	NEW	slpYsQGQSPpP+lREYFYYIDHpGMLFLDDu+hKNFTSCFKEK+FLcFFFpRLRhNc.....ouRYcp-FPalS.CGRERNalRCDDhPlVFTHllpcsssppp.....LsYsHuG-hLoV.F-Pp+lhMhPtoGRVYHPAPE+sGGlGLlRSpLAIELSppFsFssG-s..pP.PTHFpWsGppaELspcWhcs	...........................t............t.phREYFYalDHpG....LF........LDDu+hKNFhoCFK-h.pFL.FFFpRLR.Np............................osRY.pt.......pFPalS.CG+ERNFlR.....C-D..pPlVFT.cl..lttspt.t.t..................Lsastu.uptLslP.FpPppLhh.spsGRlYH....PA.....P....p.....p......s......G.....u...l.....GLV+StLAhE.LStpFpats.....st........t...Psph.WpspphtLp......s...........................................................	0	30	37	54
+14808	PF14957	BORG_CEP		Cdc42 effector	Eberhardt R	re3	Jackhmmer:O14613	Family	The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton [1]. They may function as negative regulators of Rho GTPase signaling [2].	25.00	25.00	25.20	25.20	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.70	0.71	-3.20	13	233	2012-06-21 12:15:36	2012-06-21 13:15:36	1	5	43	0	137	195	0	116.20	30	44.46	NEW	hlKNAlSLPhLsspputphsstph................sKS.SSSPsKpsp.ttt...........p.hNuuuutus...hc.phsEppFGpLTDhs.............................sstspssuhc+A-SlhSFHlDLGPShLuDVLulMDKpth-pc	.................................................................................................................................................................hlKNAhSLP..lst...th..hs..p................................................t...sPs+.sp..ht..t............................hp.s.ut.st..........p.s...stpt...sphps.............................................................................................................................................s.spps..hh.cpu-SlLS...h+..l....DLGPSlLs-VLslMDpt...............................................................	0	7	23	57
+14809	PF14958	DUF4506		Domain of unknown function (DUF4506)	Eberhardt R	re3	Jackhmmer:Q9H8K7	Family	This domain family is found in eukaryotes, and is approximately 140 amino acids in length.	27.00	27.00	27.60	27.50	26.40	24.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.71	0.71	-4.60	14	90	2012-06-21 12:23:39	2012-06-21 13:23:39	1	1	68	0	65	83	0	134.90	33	35.56	NEW	p-tslLhs..ss-sp.sPC.LplphsPc...cIuulsllsSA.slEla.lG..pEYptTshGcslp...pppsc.tlphYRhclcl-.SshsshplKLLo....upchCVasu+lhls.pssslsop.....hsptIDlp+VQplLpphGo	..............p.sllhp...pspsp.pP..ChLhlpssPp...pcIsulsllSsARshEVY..l...G......p....EYCGTsR.Gc...sVs......................tssppcplhlY+p.LcL-...os..spuCclK..LLSh........uc+.psValu+lhVphpssssss..s.t..slsstlDLp+VQshhpshGo................................	0	14	21	35
+14810	PF14959	GSAP-16		gamma-Secretase-activating protein C-term	Coggill P	pcc	Jackhmmer:A4D1B5	Family	GSAP, or gamma-secretase-activating protein, also known as PION, regulates gamma-secretase activity. The holo-protein is a large, approx 850 residue protein that is rapidly cleaved to an active 16 kDa C-terminal fragment that is the stable, predominant form. GSAP is expressed in inclusion bodies and is important in brain function. It dramatically and selectively increases neurotoxic beta-Amyloid production in the brain through a mechanism involving its interactions with both gamma-secretase and its substrate, the amyloid precursor protein C-terminal fragment (APP-CTF). Accumulation of neurotoxic beta-Amyloid is a major hallmark of Alzheimer's disease.  Formation of beta-Amyloid is catalysed by gamma-secretase, a protease with numerous substrates that catalyses the intra-membrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) [1].  The secondary structure of GSAP is largely alpha-helical, lacking well-defined tertiary structure. GSAP represents a type of gamma-secretase regulator that directs enzyme specificity by interacting with a specific substrate [2].	27.00	27.00	30.40	42.60	26.40	20.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.29	0.71	-4.34	14	77	2012-06-21 13:25:58	2012-06-21 14:25:58	1	3	66	0	53	85	0	111.40	39	13.83	NEW	L-hsptLhpLlp+hhthshp.....hpph+shsh.lsphssspc...htlFplhpRhhpAspsLshPhP.GFpohashLGhRsLshcsFLQYl-psVhpLotsslptlhpDl.-so.ccs..pphKa	........................L-h.ptLhpLls+hhthsh+.......hcph+uh.L.....hsphuust.c...aslFclhpRhhpAs.polshPLPsGFpohaThLGh+CLshcshLpYl-suVh.Lopsslpplhp.Dl.-so.pp.s...chKh.........	0	17	22	37
+14811	PF14960	ATP_synth_reg		ATP synthase regulation	Eberhardt R	re3	Jackhmmer:Q96IX5	Family	Members of this family are subunits of mitochondrial ATP synthase (F-ATPase) [1-2] and vacuolar ATPase (V-ATPase) [3]. In F-ATPase, this subunit regulates mitochondrial ATP synthase population [4].	25.00	25.00	25.90	25.20	24.30	18.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.45	0.72	-4.77	11	92	2012-06-21 13:36:47	2012-06-21 14:36:47	1	3	58	0	53	100	0	46.90	48	42.08	NEW	MAu....tt.thpGhp+hFNupThsGRANsAKATYAuluLlhlaa+h+.pK	...........MAG.....tt.phpGhpKaFNShThsGRtNsshATYAuluLlllaa.+l+.+K.....	0	15	18	32
+14812	PF14961	BROMI		Broad-minded protein	Eberhardt R	re3	Jackhmmer:Q96NH3	Family	Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth [1].	25.00	25.00	25.30	25.00	16.30	22.50	hmmbuild  -o /dev/null HMM SEED	1296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.44	0.70	-14.11	0.70	-7.43	2	151	2012-06-21 13:57:55	2012-06-21 14:57:55	1	4	62	0	96	138	1	532.70	29	89.28	NEW	LQshLRpLhpSVK-+IoGAPSlECAEEILLHLEETDcNFHNYEFVKYLRpalpsoLGuhIE.EhEpaTpspsps.tSG.DTlVptVTKpTpESppYKpMMpoLKphMMhVVEShINKFEEDpMpppEhp+KIQ+ppS.S.hsDNCSDSDSSFNQSYtFh.ptpLQlIh-pLDPGpP+EVRaEALQoLCpAPPSDVLsCEsWTsLpcpLosuLoDPDP.hSD+lLpFaApTFo.SPLphTK-IYsSl..sKhLchaFL.+c.phPohoTuIDhspPshhpLLKphRLhN-aQKEssoFWIRHPEKYMEEIlENTLSLLul+p-Q..Sp.sSpK.L-PIahhuLlDhKAsWFKKWMHuYYSRTsVLRLLE+KYKSLlssAlQQCl.Yh-.C-Ahp.-EhLth.+phtppp....tphhYoupELpalYFlHSLClLGRLlhYTpGR+hFPIKlKpR+D.VoLTDLlVlhhplhY.pPp.PphspsAhhDshSPsshVhEVLRhLCDppECAVECLYp.sVIEsLLtPlhsLhpGphst.ss.EoALhHhADhLARIAos-cGLoLLLYscNhsSuEtcS.ouAHlIsQFopKLLsc-lpl.suSpM....pGAFI.VCRQhYsTCEGLQVLhPYSLHEsIApAW+pTS.hSERlPTPV.sussh.u.SQE.QsshAWEE.LLDsLLNFAATPKGLLhLQpTGAINECVTaMFsRasKKLQlSRpcKFGYGVhVTQVAoTAsGhlALQSSGFlpTllsELWusLECGR-DVRlsHP+STPhDPIDRSC.KSFLuLVNLLs.P.AVaELlGppsLPNKpEYsLREhsTsVlDlhDRLIIlNS-AKI+SLFNYEQSHhFGLRLLSVlCCsLsohLLLEuQYplo-lLLpuQc-NlhEsspuct-FIIDGLSVERNHlLVRIshlGGP.ERhLPPRsLpKGsDPYPWPMhSoYPLPphYl.-VsK.hchKQ-s-lGthLhp.K.o-+pspWh-sCRRQFCKhMtsKsshloG.sLh-LLEhhVLHLSpSss-CaFPssE.pssDssVKscSLSSVpQLGlcholRYGKFLpLL+-suEpDLsLlLKHCpcFLpQQps.lpSpL............ssYsGHDWFsSolFhlMhGDht+oLphL.+FSRLLsSAFLW.PRLH.ShaLsh-hhpSuIHPlY.CosHYlEMLLKsEVPLVFSAF+MSGFsPSQIClQWluQCFWNYLDW.EICpYlsTCVhhGPDYQVYhCluhhRHLQQDILQHTQTQDLQVFLKEEslpGFRVSsYhEYMEhLEpsYRshVLpDMRsIhspSo	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	33	35	68
+14813	PF14962	AIF-MLS		Mitochondria Localisation Sequence	Coggill P, Hetherington K	kh6	Jackhmmer:Q8TDB4	Family	This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with Pfam:PF07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor [1]. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.	27.00	27.00	32.20	28.80	25.10	24.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.24	0.71	-4.63	7	112	2012-06-21 14:32:17	2012-06-21 15:32:17	1	4	39	1	56	87	0	138.80	31	31.37	NEW	MahpRAV.+pLA..hRAssssAPLt...KDA.........olRthSSsthPGsSGoNMlYallVGsoloAGGhYsYKTVoucps+asE+hsplcp+TKuElpP..hpucpEslupsEcAssE.......As..olsEus.....sl-sEEsPsA.shssscEus.ssssps..EAs.sEssslsuEstPcVsD...AAs..Eos..ssEss.EVp	..............................uh.ppLs..hRsss.....sht...+st...................hRphuSsussGu.sG.sNhlYhLlVGlossG.uGhYAYKTlppDppRYsERlssl....pp+s+.tp.h..p.......................................................................................................................................................................t.............................	0	2	7	21
+14814	PF14963	CAML		Calcium signal-modulating cyclophilin ligand	Eberhardt R	re3	Jackhmmer:P49069	Family	Calcium signal-modulating cyclophilin ligand was originally identified in a screen for cyclophilin B-interacting proteins. It is likely to be involved in calcium signalling [1]. It has also been shown to interact with many other signalling molecules including proto-oncogene tyrosine-protein kinase LCK, tumor necrosis factor receptor superfamily member 13B and EGFR [2-4].	25.00	25.00	25.60	25.50	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.69	0.70	-5.03	5	67	2012-06-21 15:17:21	2012-06-21 16:17:21	1	5	46	0	39	60	0	205.50	50	78.87	NEW	SASQRRAElRRRKLLMNSEERlNRIMGhH+PssGsp-Espp-oc..h-.DKosPLoLsSlSKRo.llpGDuVp..ouss-.psuSuu-t+ssplG-KLD.a.Kssphpu-DsutlRcRNRGDlsS-ussRss+cGL-pYLSRFDEAMKLRsQLssEKPSQDcGsssEE....FDSFRIFRLVGsALLAlsVR.hFVCKYLSIFA......PFLTLQLAYMGLSKYFPKGEKKVKTT..VLTAALLLSGIPAEVINRSMDTYSKMGDVFTDLCVYFFTFIFCHElLLaaG	..........................................oAuQRRAElRRRKLL.NSEpRhNRIhGap+s.ssssp-.Es.phpth......-.-+.pshsh.sSsSKR...sshGssss........suss-.p.ss...hhs.t.h.tp.p..........cs.htlR.RpRst..ssp..shtpss+.GLppYLSRF--AMKLRtQLhsEKPsQ-sGsssEE....hDsFRlFRLVGssLLAlhVR.hFVCKYL...S.IFA......PFLTLp..LAaMGL.KYFPKsEKKhpTT.........VLTAALLLSG.IPA..EVIsRSMDTYp...+Mu-.VFsDL.CVYFFTFIhsHElh.hhG...........................................................................	0	6	10	23
+14815	PF14964	DUF4507		Domain of unknown function (DUF4507)	Eberhardt R	re3	Jackhmmer:Q96N11	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 434 amino acids in length.	27.00	27.00	28.30	28.20	25.10	23.10	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.19	0.70	-5.71	18	101	2012-06-21 15:24:45	2012-06-21 16:24:45	1	3	82	0	69	102	0	311.90	35	86.20	NEW	M..scl+psL++hcFPpsApEALt+l-.......pLhssR..s.pttchsh-llsEFlFtEhc.ccspttp.................phsslQELQLlplLs-a...Fsps.us-AsRsslFhuLFuspts.t...........................RhplLu+LVShAVussssslLsuAGhWMQQ..lGssSs.SlcLApsllsDYhsLs......ssos-pLKpLshluP+FsusFlTAVs-LY.s.....tpsp.tsPPssLL-lIs-Wlo-NPp.LClss.p...thsLPs.........Gulshs.hTPlsGLlRW.CVLAPLspspppp..........................lYSKLHLulLpuL....................phssssspttslsupcLspllcsLpphhpp......sssssspthplul-RhAQAlQVAhuosClhsNpppLhshLppLPtp	......................................h......p.shh..ph.tsAhEsLhpl-...........p..hpp.......hpphshpllpEFlF...p...ccss..p.................phsslQELQLlclhssY...Fpcp..scDusRphlF.uLFuspts.t..........................p....RhplLu+LVShAV...............u.ssphPlLpsAusWhQp...........s..ss...hslcLApslVcDYssls............................ssohppL+pl.psuP+FsspFlTuVssLY.............sst..h.PP.sLL-hIspWlhEsPp.lhhs.hp....shsL....Ph...........Ghlth....TPLsGLlRW.sVhAPLs.ppp.......................................hYSpLHLulLpsL...............................hp.ps.hsphthl.hpchsslV.cplpphssp.......hss.psspthphul-RlAQAlQlAhuosslhsspppLhslhppLP...........................................................................................................	0	23	29	50
+14816	PF14965	BRI3BP		Negative regulator of p53/TP53	Coggill P, Hetherington K	kh6	Jackhmmer:Q8WY22	Family	This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours [1].	27.00	27.00	66.20	65.00	25.20	21.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.07	0.71	-4.90	26	99	2012-06-21 16:19:23	2012-06-21 17:19:23	1	2	38	0	51	85	0	172.40	45	78.46	NEW	hpphupohppTLsshlGtEsh+slpchhSplh.thspulsVhh.sL.tIhspLLssLGLDuspLTQ..hhSPupVpo....hLLhsuusLlAYWhLSLLLGhshuLL....GRhhWhl+lsLFhhuhVhll+ph.sssp+AlL.Lshlsshhhhot.sGshhpt..........spLEtKlcpL-pQlc.LphRhpR	........................pphupuhhtolsshhG.-sh+hltchhoplh.thspulsshhtsLhtlhscLLcsLGLDu..spLoQ.....hhSPupVpo.....hLLhsuusLlAYWhLSLhLGhshulL....GRhhWll+llLFhhuhVhllpp.h.s.sp+AlL.Lshllhhhhhot.sG.hhpt................spLEtKlctLEpQlc.LphR.pR....................	0	2	5	18
+14817	PF14966	DNA_repr_REX1B		DNA repair REX1-B	Eberhardt R	re3	Jackhmmer:Q96EN9	Family	This family of proteins includes Chlamydomonas reinhardtii REX1-B (Required for Excision 1-B) which is involved in a light-independent DNA repair pathway [1].	24.00	24.00	24.00	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.13	0.72	-3.61	20	102	2012-06-22 07:42:38	2012-06-22 08:42:38	1	2	75	0	64	107	0	91.40	35	42.95	NEW	stsLL+pFhplQpcRApsYscaccGFpsalpsusp...ssYppLCsclTp-FsshScp........llplEstLp..chsRs-lApllcslQppEKpKLpLTAplQlLK	...............h..tLlpphhtlQpcRsphapphccGappYlpousp...stYpphspc.lTptFsssS+p..........................VltlEutLtt..hspssLAphl+slQptE+p+LphsAhlQlh...................	0	26	39	49
+14818	PF14967	FAM70		FAM70 protein	Eberhardt R	re3	Jackhmmer:Q8WV15	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 241 and 349 amino acids in length. The function of this family is unknown.	27.00	27.00	33.10	27.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.22	0.70	-5.23	7	144	2012-06-22 08:12:48	2012-06-22 09:12:48	1	3	39	0	58	143	0	275.00	57	97.69	NEW	h.s...s.sssl.h.sshuuFs+RK+sSlahssoLLlVSlhILTlGLAATTRTENVTVGGYYPGlILGFGSFLGIIGhNLlEN+RQMLVAuIVFISFGVVAAFCCAIVDGVFAARHI-.RPLhuGRCpaaSSssuahhD...h......................EVTCpo.s.stCpLKV+SNTCYCCDLYNCtsp.E.ssuYYEalsVpuCQDVlHLY+LLWuuslLNllGLFLGIITAAVLGuFKDM..sshup.shu.ss.Ppl.YssstQlhuYsuFh.ossslPshouY..sLQ.suhFPu.........ossSsLu...DsQssusS....hhsspsPPpYuPsYa.PsEKPPPYoP	...................................htsFsRRK+sSlahssoLLlVSlLILTlGLAATTRTpNVTVGGYYP.GlILGFGSFLGIIG.sLlEN+RQML....VAuIVFISFGVlAAFCCAIVDGVFAARHI-h+PLhs.s...RCpah.spssth..h-.h.t.........................pV.sC.phs.s.Cp.+l+uNTCaCCDLYsCGsp.EhssuY.....YEalsVpSCQDl.lHLY+LLWuuTlLNllGLFLGIlTAAVLGuFKDM........s....u..........s.s....ss.Ppl.Y.st..Q..lhuYssah.osspLPsh.SuY..shQ............s.usFPu....ossos...lS....-sQ.sso.ssS.ahh..sssAPPpYuPsYa.PhEKPPPYsP.......................................................................................	0	3	7	22
+14819	PF14968	CCDC84		Coiled coil protein 84	Eberhardt R	re3	Jackhmmer:Q86UT8	Family	The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.	25.00	25.00	25.50	25.50	24.50	24.60	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.54	0.70	-4.93	13	109	2012-06-22 08:26:03	2012-06-22 09:26:03	1	3	64	0	60	112	0	256.10	32	89.59	NEW	aCplCRpNHsp.G++H+Y.ssH+puLsshLs+FpsKls-lRthL+sPsl.c.t..pscs+hWChFCct-lt-psS....ohssusAlpHLASs-HlKsl++Fhh+aGushcph-pFpIocs-hu+acppsppshsphpsps-shhsptsssl+cl.cs.........p.pp.phh.pshpss..p..ppP..sst...pssshshhhhssp.t..httotts.....................................................ssshshs.ss...shshtts..G..sL....sslus..shsut.GNVHoGAsPPWLpss-cs.....tssp..phsPSspuhhpppcptKh+KLNPcR..V...GAsascc...p+................ssssWLPsFGRVWQSGsRpcSR+EFc+E+pphcc	..............................................C.lC+.sa.p.GctHhY..pHpppLpthLp+hh.plpssRhhl+ssps.p..............tpcpphW.ChhCst-lpcp.S.....ohhhushlpHLA..Ss-Hh+sspcFhhcptuphp.h-..pFhlo..p-ht+acpph...phhpph..tppp-t.h.tt.hs...pphcp.........p.p.p.h.psh.ps.......s.......p...........................................................................................................................................................................t..s.........h...h....s.lu....t.ssh.GNlHoGA.PPWh.tp-t..........t.........p..s...t.hhppp....p.ptK.+KL.sspR..V...GAsascp...pp................ssssWLPsFGRVWpsGpRhpSR+pFctctt....p....................................................	0	14	28	41
+14820	PF14969	DUF4508		Domain of unknown function (DUF4508)	Eberhardt R	re3	Jackhmmer:Q9NWQ9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 253 amino acids in length.	27.00	27.00	28.30	27.80	25.70	24.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.49	0.72	-3.99	12	83	2012-06-22 08:49:40	2012-06-22 09:49:40	1	4	70	0	53	78	0	98.90	44	54.48	NEW	stpEhRhllpWFtpWSthQRpcFLpsLlpK........Asss.p......lsuLlsuLpsLsl..pD+PPSlFpCpl+LaspWFpsWs-p-+sphLppLcchDscFst+ahpclu	....spEh+ClLpWFssWSssQR-cFLpDLVuK........................AVPG.K..............lpsLLcuLppLuV...sD+PPsIF-CQL+LacQWFpsWuEpERNcFlcpLEtt-scFssKaaptlu..............	0	11	15	33
+14821	PF14970	DUF4509		Domain of unknown function (DUF4509)	Eberhardt R	re3	Jackhmmer:Q86SX3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 212 and 449 amino acids in length. There is a conserved WLL sequence motif.	27.00	27.00	27.90	27.50	25.90	24.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.33	0.71	-4.63	8	80	2012-06-22 09:10:21	2012-06-22 10:10:21	1	4	45	0	38	72	0	151.30	42	43.60	NEW	DR..PEAshsLWplLa................phL.psLs-hph........hsssts-sp.hpl...VKpALtspGY.PphphhQLPpDsupGSRELLLALuWLLA+ssllEph..Ltpp+Vphucthslsp..........................sEs.sS.u.P.ustht..scts...s-l+clpWLhG+LRapaRsLhopppEQstLlsKIHhhTp.ss+Sc....QsLuH..LSVsEschL+DPEshpp	...................................................hWplLh................t.L...l...t.........htp.h.psp..hph....VK.sLt..GY.PphthhpLPpDus....pGSRELLLALuWLLucssl.-ph....LtptpV...l.ucph.s.lsp................................s-shsS.s.s.....ustht....scss......sDlRtlpWLhG+LRapWRpLhspQQEpCtLLsKI.H.hTt.usp.p....psLsH..LSVsEschl+cP-shpp......................................	0	11	15	24
+14822	PF14971	DUF4510		Domain of unknown function (DUF4510)	Eberhardt R	re3	Jackhmmer:Q86SX3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 242 and 452 amino acids in length. There are two conserved sequence motifs: LEA and WMD.	27.00	27.00	91.90	91.90	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.07	0.71	-4.07	4	44	2012-06-22 09:22:30	2012-06-22 10:22:30	1	3	20	0	11	48	0	161.10	69	41.03	NEW	TCusEsPsssuQPsFLPhlsE.sGuscL-hVsppLQALpEELppssEsRRAAWEA+lGGsupGsEWSAuR+AspEAVppE..L.uALp........tsWEcuusPu....QPp.sP+RLV+u-sGAuss.tsLpAApVItsLRu+EACLctsL+pLQpQCRQELARLAuAhPGLIWI.PPt	.....................TCuPEsPAAASQPTFLPhlPE.pGsGELELVsRELQALpEELp.......EAsEpRRAAWEAKAGGCGpGPEWSAu.RRASREAVE+E..L.uALQ........psWEpDuGPA....QPH.GPHRLVRREDGAAGs.psLRA.AEVIRTLRSQEACLEAVL+pLQGQCRQELARLsGALPGLIWIPPPG.	0	1	2	2
+14823	PF14972	Mito_morph_reg		Mitochondrial morphogenesis regulator	Eberhardt R	re3	Jackhmmer:P17152	Family	This family of proteins regulate mitochondrial morphogenesis via a mechanism which is independent of mitofusins and dynamin-related protein 1 [1].	27.00	27.00	52.90	31.30	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.88	0.71	-4.84	10	101	2012-06-22 10:12:39	2012-06-22 11:12:39	1	3	80	0	70	99	0	156.30	54	87.21	NEW	Sso....stlIREVYDuENAHEpFEhEL-+ALEAcsshIVIEPo+LGDETuRWIsVGNCLHKTAVlSGlAuLhouLlWh.-Rh...llusPhuulSlhCsuLYslSWpaDPCCcYQV.EpDspcLs+LP.Ls..ssSSPVVLVR+DsppRKhLHpsloluuAuaCAW+lYcsa.K	.................h.sssaIl+ElYsuENAp-pFEhELEpALEAphcaIVIEPoRlGDETARWIsVGNCLHKTAVLuGsusLho...sL.................hh......s....chp........aIulPuGsLSlsCssLYulSWQFDPCCKYQV..Eh.Dsh+Lu+LP.LpsLos.SoPVVLVR+DDh+RKhLHsoIALuAhsaCsh+lYchY.t.....................	0	23	28	50
+14824	PF14973	TINF2_N		TERF1-interacting nuclear factor 2 N-terminus	Eberhardt R	re3	Jackhmmer:Q9BSI4	Family	This is the N-terminus of TERF1-interacting nuclear factor 2. It is required for the formation of the shelterin complex. The shelterin complex is involved in the protection and maintenance of telomeres [1-3].	27.00	27.00	27.50	28.70	26.50	24.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.74	0.71	-4.06	12	102	2012-06-22 11:39:58	2012-06-22 12:39:58	1	18	37	0	46	84	0	124.00	38	29.97	NEW	WQVlppRslcHaG+ltEFVshlspsVP-Llsh+p+tpLhhGLRA+hlLEhhcppcshs..hptlp.Hlsph....ps.psptpDhch..............cpscssFhcLVpsLlcDspt+cpahpphh.tEYGssasssLcpLhhEFLp+L-plL...PlPshpp	..................WpVlctRpVcHas+l.EFlp.lptssP..sLlpa+c+t+LhhGL+A+lllEhhhttps..hs..Lpslp.Hhsc...........tsptptpDhch...............cuppsFhp.VcpL....csP.chtphhQ...h.t-YGpsF.s.uhcpLhhEaLspLEphLPssphpp..............	0	3	7	24
+14825	PF14974	DUF4511		Domain of unknown function (DUF4511)	Eberhardt R	re3	Jackhmmer:Q99622	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 116 and 127 amino acids in length.	27.00	27.00	28.90	30.40	26.50	19.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.33	0.72	-4.29	16	82	2012-06-22 12:03:31	2012-06-22 13:03:31	1	5	71	0	61	72	0	99.00	47	71.78	NEW	shosEpAKslLs-lLpulspP-Nut+lp-A+csuG...N-MlKhMQhVaPlssQIQh-VIKsYGFs..sstEGllpFspll+phE+-DsElApLpsplRohaLPP.....lslss	.......hosEpAKslLs-lIpAhssPENuh+hsEA+-sAs...N-MhKMhQaVhPlssQIQ.EVIKsYGFs..sstE.GllpFupLl+phEppDsEIApLpupl+ulaLPPhsls.s..................	0	18	24	42
+14826	PF14975	DUF4512		Domain of unknown function (DUF4512)	Eberhardt R	re3	Jackhmmer:Q8TCD1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 74 and 104 amino acids in length. There are two completely conserved residues (C and P) that may be functionally important.	27.00	27.00	29.90	32.10	22.10	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.66	0.72	-3.16	36	88	2012-06-22 12:35:03	2012-06-22 13:35:03	1	2	72	0	54	79	0	80.60	34	93.55	NEW	VClPChlIPlLLala++FlpPllh+hhsP.....W..KcA.tp....ts..ph.hpscsssCsh..........................................pspspst............tt.st.tssssspsKK	..VCIPCIVIPlLLWlY+KFlpPhlY.hluP....hWs.Kss.pp..psts..ph.hpspssss...............................................................................tt...............................	0	13	17	37
+14827	PF14976	FAM72		FAM72 protein	Eberhardt R	re3	Jackhmmer:Q86X60	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.	27.00	27.00	34.70	29.40	25.70	23.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.92	0.71	-4.37	7	81	2012-06-22 13:09:17	2012-06-22 14:09:17	1	2	54	0	52	72	0	127.70	55	75.13	NEW	MSss.thsFpD+sVohLsC+FCcpVLspRGMKAlLLADT-h-LaSTDIPPspslDFlGpCY.Tp.CKCKLKDIACLKCGNlVGYHVlsPCpsCLhSCNNGHFWMFaSpuVhshsRlDsoGsNhLLWGsL.P-h-Ess-Eph.....phstEEhlR	.....................Ftp+pV.hLsCpaCcplLssRGMKAVLLAD.Tcl-LaSTD........IPPsss....VDFh......G.........p........CY.h...........T..............chCKCKL+DIACLKCGNlVGYHVllPCssCLLS......C...N....NGHFWMFHSpAVhslNRLDu.oGh..shLLWGsL.P-h--sps-p......p.stEphlR..........................	0	26	28	34
+14828	PF14977	FAM194		FAM194 protein	Eberhardt R	re3	Jackhmmer:Q7L0X2	Family	This family is found in eukaryotes, and is approximately 210 amino acids in length. There is a conserved YPSG sequence motif. The function of this family is unknown.	27.00	27.00	29.80	31.30	26.80	25.10	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.27	0.70	-5.34	13	112	2012-06-22 13:34:15	2012-06-22 14:34:15	1	4	50	0	70	110	0	189.40	30	29.71	NEW	ssppshhtchYcpGshF.hhhhPDGoupl..aYPSGNlAllhlss.ctsp..hhsllhEDsspss.....lLALFssoG+ussYasNGs...lhLsls.tGGhhsDppGs+h+pWsW.........sspscss....shpslplplNchlslRlhsQDKlslsFtshspps........plslGo+hhhlpP..ctlst.+p......p..c-hhhsspttK...hp+Lls+hcsplshssophh-plt.PutL	..........................s..ptp...phhpps.ha.hh.F.DGos.l....aYPSGNlAlhhlss...phst..hhshlhpDtspss........lLAlhsspGpussYassss...hhlhls.tGGphtDp.pGphl+tWsW.........sspsp.s....shpsl.hplNc.ltl+lhsQDpI.loFh.uhs.pps........plslusp....pP..cthsh.+h..........hst..c...h.sph.K....hpphhtclpthhphsss..hpphh.ss......................................................................................	0	22	27	36
+14829	PF14978	MRP-63		Mitochondrial ribosome protein 63	Eberhardt R	re3	Jackhmmer:Q9BQC6	Family	This family of proteins is present in the intact 55S subunit of the mitochondrial ribosome. It is not known if it belongs to the 28S or to the 39S subunit [1].	27.00	27.00	27.80	27.70	26.90	25.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.11	0.72	-3.55	11	74	2012-06-22 14:28:01	2012-06-22 15:28:01	1	2	68	0	49	75	0	88.20	41	79.01	NEW	PG..+QWIGK+RRsRsVohptKcshl+RhEhEtcspaaLs+PYLThEQEtGHApph+t...thhcthctppppKastH+hltDpL.sHLNlscpW	.........PG+.ahGK+Rhs+.Vohptppshh+cLEhEtcNpaaLs+PYhTtEQEtGHAtch..+p....................ts.hcthcttphpKa.sHhhlt-pL.sHLplscpW..............................	0	14	17	33
+14830	PF14979	TMEM52		Transmembrane 52	Eberhardt R	re3	Jackhmmer:Q4KMG9	Family	This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 160 and 236 amino acids in length. There is a conserved LLCG sequence motif. The function of this family is unknown.	25.00	25.00	25.00	29.40	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.10	0.71	-4.32	5	88	2012-06-22 15:00:50	2012-06-22 16:00:50	1	1	32	0	42	84	0	134.20	47	70.79	NEW	--sCcsoDpCs.sAcWlsLWYVWLILVslsLLLLCGlTAuCVRFCCL+Kps.sQsapsuAhQPCEVTVIAhDsDSTlHSTVTSYSSVQYPhuhRlhhsFu-hDssuMsPPsYSLYAsEsPPuYEEAlKMhKoRpEVAtsSQKsscLsuloEpEs	.....................................t.C...sp...C...t.s.cWspL.WYlWLlllhshLLLLCGlTusChRhCCLp+p...Qstps.u..Ph-lTVIuhDpDS.olpSTlTShpSV.hPhuhR.l.hshtphss...u..hP.......u.-h.PuYEEAl+M..sR.psshsupKss.L.ssst.c..................................................................	0	2	3	11
+14831	PF14980	TIP39		TIP39 peptide	Bateman A	agb	Jackhmmer:Q96A98	Family	\N	27.00	27.00	34.30	37.00	21.80	19.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.50	0.72	-4.33	3	29	2012-06-22 15:25:55	2012-06-22 16:25:55	1	2	23	0	16	22	0	49.80	68	39.08	NEW	u-WuSPuuspsKRNLVVADDAAFREKSKLLTAMERQKWLNSYMQKLLVVNS	........tsWus.usshsRRSLALADDAAFRERARLLAALERR+WLNSYMpKLLVLDu.	0	1	2	5
+14832	PF14981	FAM165		FAM165 family	Bateman A	agb	Jackhmmer:Q5T5W8	Family	This family of proteins known as FAM165 are found in eukaryotes. Members of this family are as yet uncharacterised. Proteins in this family are typically short membrane proteins between 55 and 70 amino acids in length.	25.00	25.00	58.00	57.60	24.50	23.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.57	0.72	-4.46	4	34	2012-06-22 15:39:24	2012-06-22 16:39:24	1	1	30	0	19	29	0	50.50	72	86.55	NEW	pAL-NVPLLhYILAhKTLlLCLAFAGVKIYQuKK.EtKLK+pctEK.+R.AE	..KVLEHVPLLLYILAAKTLILCLAFAGVKlYQRKRLEAK....p+l.EAE+.++puE..........	0	2	2	6
+14833	PF14982	UPF0731		UPF0731 family	Bateman A	agb	Jackhmmer:Q4G0N7	Family	The UPF0731 family of uncharacterised proteins is found in mammals.	27.00	27.00	35.90	35.90	22.80	21.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.68	0.72	-4.07	2	39	2012-06-22 15:48:12	2012-06-22 16:48:12	1	1	24	0	23	39	0	75.90	66	83.69	NEW	shp.ssQsRRFPlEuGDS.....PGLuSuspsp......up-.sPsR.LRRCPGsHCLTlhcVPIsVYhAMttsP.....ch+sp	.PFcFGTQPRRFPVEGGDSSlt.EPGLSSSAuss......uKEhSPsRQLRRCPGSHCLTITDVPIsVYATMRKPPApSSKEM+P.........	0	2	2	3
+14834	PF14983	DUF4513		Domain of unknown function (DUF4513)	Bateman A	agb	Jackhmmer:Q6ZNM6	Family	This family of uncharacterised proteins is found in chordates.	27.00	27.00	53.30	31.80	25.30	25.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.73	0.71	-4.33	3	32	2012-06-22 15:50:45	2012-06-22 16:50:45	1	2	28	0	22	28	0	117.90	62	82.57	NEW	SGKDTsPlLPKLNNNsS-ENoYKPu+......Ks--IHLPRFSLKQGMIPRRYVMPWKENMKFRsVNLK+AEACGIHAGPLEDSLFLNHSERLCHGEDRKVVLKKGPPEIKIADMPLHSPLSRYQSTVISHGFRRRLV	........................shP.hPKls.sststEs..+..p......+hp-lHLPRFSLKQGMIP+RYVMPWKENMcFRNVNLKpAEssGIa.sGPLEDSLFLsHSERLCHGEDRKsVLpKu.PP.EIK.IADM..PLHSPLSRYQSTVISHGFRRRLl.......................	0	4	4	7
+14835	PF14984	CD24		CD24 protein	Bateman A	agb	Jackhmmer:P25063	Family	\N	27.00	27.00	35.40	34.90	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.51	0.72	-4.16	5	28	2012-06-22 15:58:32	2012-06-22 16:58:32	1	1	16	0	14	53	0	51.80	61	65.88	NEW	SNQTTVuTsSs.SSQoTSs...APNPoNATT+uuGGoLQSTASLFVlSLSLLHLY	................SNQT.oVs.ssSs..oSQsTSs...uPNPoNATTKAuGGALQS.TASLhVVS.LSLLHLY.	0	1	1	1
+14836	PF14985	TM140		TM140 protein family	Bateman A	agb	Jackhmmer:Q9NV12	Family	This family of uncharacterised membrane proteins are called transmembrane protein 140. They are found in mammals.	27.00	27.00	68.80	68.60	22.30	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.29	0.71	-4.60	3	37	2012-06-22 16:07:53	2012-06-22 17:07:53	1	2	29	0	20	35	0	151.50	64	96.16	NEW	RPRRt-QLLFMuIMVLVAsVISLMFYALLWKAGNLTDLPNLRIGFYNFCLWcEDTGSLcCHQFPELEALGVPRVGLALARLGVYGALVLTLFVPLPLLLAQCNSDEGEWRLAVGFLAsSSVLLAGGLGLFLoYVWKWlRLSLLGPGFLALGlAQALLILLLMAMVVFPPRAE.KuEs+LESC	............hhtppLLFhuIhlLsssVIsLhhYALLW+AGNLsDLPNLRIGFYNFCLWNEssusLQCHQFPELEALGVPpVGLALARLGVYGALVLTLFss.PLLLA.CstscttWpLAVsFLAhuShLLAuGLuLFLoYsWKWlRLSL.GPGFLALusAQALLlLLLhAhshFP.Rupcs.Sph-sC.............	0	1	1	3
+14837	PF14986	DUF4514		Domain of unknown function (DUF4514)	Bateman A	agb	Jackhmmer:Q5T292	Family	This family of uncharacterised proteins are found in mammals.	27.00	27.00	51.40	50.50	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.03	0.72	-4.16	4	27	2012-06-22 16:13:00	2012-06-22 17:13:00	1	1	17	0	11	30	0	58.40	77	55.09	NEW	DlGGAQVLATGKSAGsEIDhKYAlIGTALGsAISAGFLALKICMIR+HLFDsDSSDL+STs	.DVGGAQVLATGKssGsEIDaKYALIGTAlGlAISAGFLALKICMIR+HLFDsDSSDL+ST........	0	1	1	1
+14838	PF14987	NADHdh_A3		NADH dehydrogenase 1 alpha subcomplex subunit 3	Eberhardt R	re3	Jackhmmer:O95167	Family	This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic [1-2].	27.00	27.00	29.60	29.60	26.20	26.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.96	0.72	-4.07	6	72	2012-06-25 07:58:29	2012-06-25 08:58:29	1	2	38	0	27	63	0	76.80	64	83.37	NEW	MAuRluAFLKsAWsKEPVLVVSFsIGGLAlIlPhlSPaTKYosMINpATPYNYPVPVRDcGNMPDVPSHPpDPQGPSL-WLKsL	..............u.luAFLKNAW..sKEPVLVsSFsluuLA.lILP.lSPYTKYusMINp...ATPYNYP................VPVRDD....GNM..PDV.PSHPpDPpGPSLEWLKpL............................	0	1	3	7
+14839	PF14988	DUF4515		Domain of unknown function (DUF4515)	Eberhardt R	re3	Jackhmmer:Q6ZUS5	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.	24.30	24.30	25.40	25.30	24.20	24.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.23	0.70	-4.66	11	151	2012-06-25 08:27:04	2012-06-25 09:27:04	1	1	48	0	91	151	0	173.10	28	47.21	NEW	Es+hFLEYLpc+sEcppcph-pLWpsYlQpppEI-c+RpELsScaspppupLpppLhQpcKh.pusL+pcLQAlcsluplKEpQ-pcIpsLccEhcchpu-puhpc+Es+hQFLcEKutLE+Qlp-hchhphGccts+ELppKspAhchtAKphhp-aspulp+ENppL++cLhQLhpEhpcLcsp+p+LEpp+QplpcpQWYLEuL	.......................................hhpaLpppspcppp.hppL.pph.ppptph.p.pc+p.ch.pp...YstphstLc.tphhpppp...s.lppcLpslcphpth.............K.p.-p-lpsLccphtphptcpppphpchctpFhpEKttLEc-s.Epcl..h...Luc+Ac+E.............A.hhtl.phspslhcENhpLpctLh.hhc......csptLptppppL.pcp+ptLhppp.h.p....................................................................	0	23	28	48
+14840	PF14989	CCDC32		Coiled-coil domain containing 32	Coggill P, Hetherington K	kh6	Jackhmmer:Q9BV29	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 188 amino acids in length. The gene that encodes this protein is C15orf57 but its protein product is called Protein CCDC32 (Coiled-coil domain containing 32). The exact function of this protein is still unknown.	27.00	27.00	27.90	34.60	19.70	25.40	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.81	0.71	-4.37	14	92	2012-06-25 08:39:40	2012-06-25 09:39:40	1	2	70	0	54	88	0	137.80	41	74.06	NEW	D.Wsphsss..psppt......pssppFcDsFpsshstt.tptp..................p....tPLsDS-sYLAsLER+Lp+l+uts......chLcoLuptKc-Chc+LLps.....shsspha.ph.-hDpsshpp.L+RaLhP.c.AlsstEl.aLl.h-tLppp	......................D.WsEhssslspstpp.....sssssuFpDSFhss.stsptppps.t.................s.tsa....tPLpDSEsYLASLE+.KL++IKGhs.......p.-VTSK-ML+oLuQAK+ECWDRF.Lp-.........phsuEhF.-s...l-sDcs.......slpp........h+..RaLtP-+sAlospElpaLl.s-t..p.p............	0	13	15	35
+14841	PF14990	DUF4516		Domain of unknown function (DUF4516)	Eberhardt R	re3	Jackhmmer:Q69YU5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 56 and 69 amino acids in length.	27.00	27.00	29.10	29.10	22.60	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.29	0.72	-4.41	14	71	2012-06-25 08:52:15	2012-06-25 09:52:15	1	2	61	0	43	70	0	47.90	43	66.80	NEW	MPuG.........suhspYhhhhssulhSMhAGAplVHphYKPDLolP.l.scssp	...............MPuG.............VshssYlphhusulluMhAGApVVHpaY+PDLolPpl.sc.t..........	0	8	15	25
+14842	PF14991	MLANA		Protein melan-A	Bateman A	agb	Jackhmmer:Q16655	Family	\N	27.00	27.00	81.80	81.70	23.80	23.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.57	0.71	-4.08	5	35	2012-06-25 09:02:05	2012-06-25 10:02:05	1	1	30	12	22	30	0	108.70	59	98.78	NEW	PRcDhHa..G.aF+G+GRoYsTAEEAlGIGILIVVLulLLllGCWYaKRRSGYKpLhsKoI+lGo.psl.....+sRCspEusc+p-SKlShQEassh.pPVVPNAPPAYEKIAAEQSPPPYSP	.PRE-sHa..GaP+KGHuHSYlTAEEAAGIGILsVILGlLLLIGCWYCRRRSGYRsLhDKol+sGTQs.sl.TtRCspEuhsHpDSKlshQEpss..cPVVPNAPPAYEKlSuppSPPPYSP.	0	1	1	5
+14843	PF14992	TMCO5		TMCO5 family	Eberhardt R	re3	Jackhmmer:A8MYB1	Family	The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.	28.10	28.10	28.30	28.60	27.50	28.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.89	0.70	-5.27	9	134	2012-06-25 09:09:25	2012-06-25 10:09:25	1	2	26	0	62	136	0	210.10	29	85.47	NEW	NlpSLN.DLE+DhQRlDEANQ.LLpKIpEKE-sIQsLE+EIs.oht.uc-c..E-.Nchs.tE+EpALp-LE.ETA+LE+cNcpLs+slsELQ+Klo++pps.sssEptshcptlpE.K..s+LQp.ppSCAsQEKELsKl.p...DYppVspLCEDQAhhIK.KYQEhL.+chEc.EKEshlLE+ElsKs.sp....sSph..cssSh.hEshtpNhEcshlpKpp...p...........tFWh+hFRh.LhFhVlhFIRLLuYlhFH.lpaINPDLLVc.sLPhlLSRsoLhcLRchlFPFLTLEsE-lLP	.......................................................................................................................sLp.ch-tc.QplsctNp.hL.plp.pEtthppL.....p-lh...t.hpcp..-c...s.h...p.pps.h...h...cp.shLEhps..ph......-lppp..sct..p...h........-t.t......pt..p..c..splp...tphh..p.EpplhKl.p..................-ht...s..tphp..tD...ts..h+....chpE....hL.cphEp.ph-hhhLppc.lphh........t.......s.........p..t..h.ptt...............hh.hphhph.hhh..hhhhhtlhshhhha.h.al....h.p.hLPhhhu+thhhcLRphh.P.LsLpsEthLP.....................................	1	5	5	9
+14844	PF14993	Neuropeptide_S		Neuropeptide S precursor protein	Bateman A	agb	Jackhmmer:P0C0P6	Family	\N	27.00	27.00	89.30	88.90	26.90	15.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.13	0.72	-4.30	4	24	2012-06-25 09:09:30	2012-06-25 10:09:30	1	1	20	0	12	31	0	64.00	73	77.25	NEW	YPVssS...KVsGKsDYFLILLNSCPuRl-tS-cLAhLKPILEKsFhKRSFRNGVGoGhKKTSFRRAK	....YPVssS...KVSGKSDYFLILLNSCPoRlDRS-tLuhLKP.ILEKhFhKRSFRNGVGTGMKKTSFRRAK	0	1	1	3
+14845	PF14994	TSGA13		Testis-specific gene 13 protein	Bateman A	agb	Jackhmmer:Q96PP4	Family	This family of uncharacterised proteins are found in chordates. In humans this gene is found to be expressed specifically in the testes.	27.00	27.00	29.40	44.50	20.50	24.80	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.78	0.70	-5.24	5	31	2012-06-25 09:19:14	2012-06-25 10:19:14	1	1	24	0	18	28	0	260.70	55	92.14	NEW	Gs.....KcpoKhQ..sGtSKsuKoSul+FEKpll......sDu-EIhDAVGQSKFVLc................................NLRHYTV.........HPNLAQ.....................YYEPLKPTALQKFLAQN+KI.........................................................pSFMLKVTEYDQDKTLLIMTNNPPPCsIDHQGK-usPKYFSsELL.............LK..EosaQH....KPT-NhaLPpMPQK.............KKL+stLK............PlFPlpLl-DPsSK+EQWFRFSTDcDFKSEGRYSKVYALR+QKKMYPQLsFAPVscRph..........+ssVSKKSuS-sPT........SQVIWEPLTLSSLLEEKPTRTAPGESsFRsGRAQQWIIKsATVI	......................................................................................................................++poKhQ..pstu+h.csssh+hEKthh.........ssscEI.DsVGpSKFVLc................................................................................................................NL+HYTV.........HPNLAQ...............................................YYcPLKsTALQKFLApN+Kh.........................................................pSFMLKVT-YDQDKTLLIMTNNPPPssIspQsK-ssPKYFScELL.............lK....ppp.aQH....KPo-shhLPhMsQK.............KKLRstLK............PlFPlhh.-DPsSK+EQWFRFSTDNDFKoEGKYSKlYALR..pQKKMYPQL...sFAPVpcRph..........+ccsS..hKStSphPh........Sph...hhEPLTLuSLLEchPTRo..sPGcusFRpGRA.Q.WhlcpAsl............................................................	0	4	4	4
+14846	PF14995	TMEM107		Transmembrane protein	Coggill P, Hetherington K	kh6	Jackhmmer:Q6UX40	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 138 and 164 amino acids in length. There are two completely conserved residues (H and E) that may be functionally important and four transmembrane helices. The domains in this family vary in length from 124 to 126 amino acids. The precise function of the protein family is still unknown.	26.00	26.00	26.20	26.10	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.52	0.71	-4.00	37	76	2012-06-25 09:47:02	2012-06-25 10:47:02	1	4	60	0	51	85	0	114.90	39	64.62	NEW	L.lPsRFlslhsHhlhl..lslhauc-pslpush..........hshspt....p........Ysptcp......plsssLslohhhhslEhhGhhoGlShFssspslhphssHsuAuVhL.hFhhppWcssp..hWalFshh.SslPshhEhhhhh	........LVPuRFLoLlAHLVll..ITlaWS+-sNlp.A.sLP.........hpao.p.....p.......................Ysppct.......p.LlsuLuloluhhslElsGhhoGlSMFssopuLl....slssHsuAuVhLshalhcpWcsst..aWalFshh.ShhPshhEhhhh...........................................	0	24	30	40
+14847	PF14996	RMP		Retinal Maintenance	Coggill P, Hetherington K	kh6	Jackhmmer:Q96NL8	Family	RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively [1].	27.00	27.00	27.70	27.70	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.37	0.71	-4.28	14	77	2012-06-25 10:04:19	2012-06-25 11:04:19	1	2	67	0	52	66	1	137.00	40	62.04	NEW	LDshls-..........lspcss.ssh.s.phssppsssssshss..s...........p++Cssl.hLuGsphshGlsoshpp......+sCspLRCssCDFcVlpasshcWcpssDYLFFRNNhPchpKLpsKLhpc.GspAYuCQCsWpos..schsslps..spl+WVCuuH	...........................................................sshlp...........h.pp.t..t.......s.p..ts.sstss........................................tppCssl.alGGoshspGluoshsp........RuCDpLRChsCDFtVlpasDhhWDc........S...sD.YLFF.R.NNhP-hpKL+s.......K...............LhccpGsRAYACQCSWpol.....p-lscLpst...ppL+WVCutH...............	0	20	24	33
+14848	PF14997	CECR6_TMEM121		CECR6/TMEM121 family	Eberhardt R	re3	Jackhmmer:Q9BTD3	Family	This family includes Cat eye syndrome critical region protein 6, a protein which has been identified in a screen for candidate genes for the developmental disorder Cat Eye Syndrome (CES) [1]. It also includes the TMEM121 transmembrane proteins. The function of this family is unknown.	25.00	25.00	25.10	25.10	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.45	0.71	-4.70	17	120	2012-06-25 10:07:15	2012-06-25 11:07:15	1	2	66	0	90	116	0	190.60	31	45.76	NEW	saAhl....sWhlY.shsLh.Klshlapshhs-t....h.sh-h.hu.psLclsLulo.shLFlLLltsc+.phspu........p++hhlpshhhtlslDLLDslshlphLhcspt....hsLslhl-shllhhshlsl...hLPsluLhElshsph........t.hspchl.aslLthlhVNlPhlhIRs..hLa.......atpspssSlFhhKNlhhlhhtspphhpt	....................................................................................................................................................................................taAhl....hWhlY.hhsLphKlhhlapshh.tc........................htsh-s..h...u.p..pslplhLuls.l.P.hLalLlsuhs.chphsps........pc+cchpsphhhVsLDLLDhl.s.h......t.Lhcspp............hsLP.lahcslhhhhsalhL...slPslu....LsElshps...........................t.hsp+hh...aslLulhhVNlshlhlRs..hll.......app..p..pssoIFlhKNlhhluh+shphlp.........	0	25	39	65
+14849	PF14998	Ripply		Transcription Regulator	Coggill P, Hetherington K	kh6	Jackhmmer:Q5TAB7	Family	The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4 [1]. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins [2]. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog [3].  This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.	27.00	27.00	40.80	39.90	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-3.87	16	104	2012-06-25 10:24:52	2012-06-25 11:24:52	1	1	41	0	57	95	0	82.20	50	63.51	NEW	sshWRPWl..osp-stppspt..............stsstpspsspts.sFpHPVRLaWPKS+saDYLYppGEpLLpNFPVQATIshY-.-SDS---EE	.......................................................s.hWRPWl..sst.c...ph..t..............stu..sthstsstt..tFpHPVR.LaW.PKS+saDYLYppGEtLLpNFPVQATIsFY-.D.SDSE-Ep................	0	5	12	21
+14850	PF14999	Shadoo		Shadow of prion protein, neuroprotective	Coggill P, Hetherington K	kh6	Jackhmmer:Q5BIV9 	Family	This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases [1]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.	27.00	27.00	49.40	49.00	26.30	25.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.93	0.71	-4.29	5	54	2012-06-25 10:39:11	2012-06-25 11:39:11	1	1	32	0	11	48	0	121.80	75	86.49	NEW	CDSGAAKGGRGGARGSARGGlRGGARGAuRVRVRPAPRYu..GSSLRVAAAGAAAGAAAGAAAGLAAGSGWRRAsGPGEpGLEDsEDGAPGGNGTGRGVYSYWAWTSGAGPTssh+LCLLLGGALGALGLLpP	.......CDuuAAKGGRGGARGSARGG.....RGAuRVRVRPAPRYu..GSSlRVAAuuA..A.AGAAAGA...AAGLAAGSuWRRAAGPuElGLEDs.EDGAPGuNGTGRGVYSYWAWTSGA...GPTsph...+LC.LLGGALGALcLLRP.......................	0	1	1	3
+14851	PF15000	TUSC2		Tumour suppressor candidate 2	Eberhardt R	re3	Jackhmmer:O75896	Family	This family of proteins are candidate tumour suppressors [1-2].	25.00	25.00	26.90	26.30	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.68	0.72	-4.01	13	77	2012-06-25 10:40:10	2012-06-25 11:40:10	1	1	56	0	45	65	0	102.30	56	97.96	NEW	MGuSsSKt.cuhh.h.ssss.sssss......tssc.p..p.schcshRsusP...FVaoRRGShYaDEDGDLAHEFYEE.lls+sGp++uph+Rlp+N.LpPQGpl+hshPplHVDFPlllC...Es	.......................................MGsSuSKs.+GhWPFsusuussssts..........tssc.p..shscs+s..RsssP...FVFTRRuShaaDEDGDLAHEFYEE.TlV...TKNGpK+AKL+RlpKN.LlPQGIVKLDhPR..IHVDFPVlLhE.V........	0	11	15	26
+14852	PF15001	AP-5_subunit_s1		AP-5 complex subunit sigma-1	Eberhardt R	re3	Jackhmmer:Q9NUS5	Family	This family of proteins are subunits of the adaptor protein complex AP-5 [1].	25.00	25.00	26.00	25.90	20.80	22.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.12	0.71	-4.35	10	72	2012-06-25 10:41:30	2012-06-25 11:41:30	1	1	55	0	47	67	0	166.60	42	86.40	NEW	MVhshlIHolp........sps+VLaSphYus-.....tp.pp.shcpcR.hpKEpl....tslA+pVcSpsshp+ps......su+sss-phhp.s-psluhtEts......sGsFplhsG-sFsscphVLWhuVsuluFsLVC-sHENlhLA-sTLRpls+hLhcpl..+sLss....uuclLh.....KuD+lcAlLc+FLPpGQLLFLNcphsptLEKElp	..............................MVpuFLIHTlpss.....tss.sRVLYSphFGs-p.....spp.c.hssEccRlhcKEpl....hsVARQ...VcShspLpppA......uGcssh-htst.u-EslsLpEAs......pGsFpLtsu-PFpps+.sVlWLuVhuLuFsLVh-sHENLLLAEsTLRhLs+hLL-pL...+lLss....usplLh........+uDcltulLpcaLPpGQLLFlNppasptLccch..........	0	15	18	29
+14853	PF15002	ERK-JNK_inhib		ERK and JNK pathways, inhibitor	Coggill P, Hetherington K	kh6	Jackhmmer:Q9H6E4	Family	This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38.  CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival [1]. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival [2]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerisation.	27.00	27.00	29.10	28.10	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.25	0.70	-4.95	8	99	2012-06-25 10:48:46	2012-06-25 11:48:46	1	7	72	0	62	88	0	174.20	39	69.01	NEW	pscsppspsppssssppstKlacclFspKRcEHhpAlcplhplpph-KRhcLlchllcclh+llpcu+ptLEcusasu-.SsFP.c-p.sLpDALupllENTAFFG-LlL+hP-hoccllcpss-WpsLhpWulsaoppos.lL--socchLcLlsQEls.hscRcssYhNPY.......pct.+cphcpppcsphKKKp+Kc......hpKtPpL.....+pEL	......................................cha++hFchKR+-ph.A.lcsLhpls-hpppYKll-lhLcslh+VLc-S+thL.sushh..Pc.ssFP.pDc..plK-AhSpllENTAFFGDllLRFP+IlHphac+s.s.sWs.Ll+Wul.sFCspo...u..la...........s.p..s.p.p.l....LpLhuQELs.lsE+sssa.NPa..........ptc..p.cthptpcppcccccp+Kc.........pKtPpl.....p.....................................	0	22	28	48
+14854	PF15003	HAUS2		HAUS augmin-like complex subunit 2 	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NVX0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organising centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis [1].  This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis [2]. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.	27.00	27.00	27.00	27.10	22.30	26.00	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.68	0.70	-5.33	7	100	2012-06-25 10:53:06	2012-06-25 11:53:06	1	3	62	0	56	102	0	194.40	34	89.31	NEW	sssWsstp.h.phuGhh.uh.lASslshp.h.s.Spcss.shs............hphLpploslQtcIhphplElphhK.-KssAcLsHso.ht+KhcsLt..phsshLcsVlppK-cIhtRL.pPhsh-ClPlEAcYp+phsc...............LLhhAso.hutLpsslpshp...phc-s.phhuchLt.hslhlspspchhEsl.thREp.tplpphhsth.s.p..lp..........................................................................+clshPP.shpsp	........................................................p...phuuh..sh.lAushh.t...s..spcp..shs............hphLpploslQtcIhphplElphl+h-KcsADlsHs.hltpKhcsLp..phsspLcsVlppKcplhpRL.pPh...st-sLPlEA.Yp+.hsc...............LL.hAss..h.ttLpsplpshp...ph..pts...p.h...sphLt.hshhlspspch.hEsh.thRcp.tph....s...................................................................................................tt............................	0	11	22	32
+14855	PF15004	MYEOV2		Myeloma-overexpressed-like	Eberhardt R	re3	Jackhmmer:Q8WXC6	Family	This family of proteins is found in eukaryotes. It includes human myeloma-overexpressed gene 2 protein. Proteins in this family are typically between 45 and 74 amino acids in length. There are two conserved sequence motifs: MKP and DEMF. The function of this family is unknown.	27.00	27.00	27.40	28.80	23.30	22.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.06	0.72	-3.42	8	78	2012-06-25 11:40:17	2012-06-25 12:40:17	1	3	63	0	48	69	0	57.70	71	54.98	NEW	MKPulssDEMFPEGAGsYMDL-E.......uGGuoGhhhD.L..sANEKsVHuDFaNDF-DLFDDD............sh.	....................MKP.uV...DEMFPEGAGPYVDLDE..........AGG.STGLL.MD.L...AANEKAVHADFFN................DFEDLFDDDD.....................	0	7	9	27
+14856	PF15005	IZUMO		Izumo sperm-egg fusion	Coggill P, Hetherington K	kh6	Jackhmmer:Q6UXV1	Family	Izumo is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization [1].  There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204) [2]. There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific [1,2]. This family of proteins is found in eukaryotes and are typically between 193 and 305 amino acids in length.	27.00	27.00	42.40	41.80	22.60	22.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.18	0.71	-4.19	8	129	2012-10-03 02:52:13	2012-06-25 13:02:24	1	2	29	0	53	139	0	145.10	28	60.57	NEW	aGu+GCLpCDPphlEslspLcusLlPpch.VsshpthhptlhppMpchhF+shthsshluhlslppL-clsoalKschp+LtssohKsshllp.ELlslRcplh+cLcchL+saphc.sCsccCtlhctslLDChsCp+hos+Ch+ucaCtc-c.p+sph+	....................................uhGCl.Ccsph.-thp.hcpphhspph..s.tp..htshhphlhpthcshhhpsat.s.uhhuhlspppL-pluphlhpphppLhpsshpsshhlp.ELhslhcpthcplppsltpaphc......hC.ccC.slht..hl.C.sCpc.hhtCh.uh.Ctppt....thp...........................	0	4	4	8
+14857	PF15006	DUF4517		Domain of unknown function (DUF4517)	Coggill P, Hetherington K	kh6	Jackhmmer:Q9GZN8	Family	The function of this protein remains unknown. This family of proteins is found in eukaryotes and are typically between 160 and 182 amino acids in length.	27.00	27.00	30.50	30.00	23.70	24.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.19	0.71	-4.38	16	94	2012-06-25 12:06:34	2012-06-25 13:06:34	1	2	70	0	54	82	0	136.30	48	83.71	NEW	p+HVHFDpp.......hHDssl.............h.hp.pscu.shhV+lGFLplpHRYcIchslPs.s.hhs.....ts.sshs....slPshps+ll.....shs.....ssssscp.hcshlEahAaKEtlL+EcltLsuppssspplcllltARVLu+t+GTPML+sGIHClGVEh-.p-S.EtSDWpGFc	..............................................................................ppHVHFDpp........h+DS.sV..............hspppuDs.sh.lV+lGFLpIhHRYcIsFoLPs.s.hhs.....pshpphs.....sPslHl+lh.....sls......hsEt.....hphEa.AaKEtlL+EchhLsspsss...........spplplhlpARVhs+p+GTPMLhsGl+ClGs.Eh-..-S.EtSDWtGFD...........	0	18	22	36
+14858	PF15007	CEP44		Centrosomal spindle body, CEP44	Coggill P, Hetherington K	kh6	Jackhmmer:Q9C0F1	Family	CEP44 is a coiled coil domain found localised in the centrosome and spindle poles.	27.00	27.00	28.00	27.00	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.65	0.71	-4.44	13	98	2012-06-25 12:15:38	2012-06-25 13:15:38	1	3	67	0	57	87	0	127.10	46	34.24	NEW	Dl+ssLc+LcptLRslpYP.....tclDhstLcpGDPuAhLPllcYsLhsYSppluchLlcpGaE......L..hu.KoDLRFlEslaKlLR-pFsY+PhLotpQFhp.pGFAE+KlhllsDIls...hlhc+H+Els+tp+tpspphpp	..............DLKpsLRpLEpsLRhLsYP..............p-VDhsGLhKGDsuA.LPIISYuhTuYSshVsElLh-.s.slE......L..hu.KNDLRFl-sVYKLLRDpFsYKPlLTKpQFlp.sGFAEhKIpIlCDIls...tVhKKHKELsphpKh.spttpc.....................	0	22	30	38
+14859	PF15008	DUF4518		Domain of unknown function (DUF4518)	Coggill P, Hetherington K	kh6	Jackhmmer:Q5JPI3	Family	The precise function of this protein family is unknown but it is thought to be involved in apoptosis regulation.	27.00	27.00	37.10	31.80	26.40	26.20	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.75	0.70	-5.35	14	96	2012-06-25 12:29:39	2012-06-25 13:29:39	1	4	68	0	56	90	0	239.00	41	84.87	NEW	LS-pc+pGhR-LLtphss.ssLhpLscoVTppllc..l-sp-EAlchIlsaopsspcLL++++IpR-lLF+YLtp+tsssssshsKssLlp+llpaWppphstp......spps.ppsptstpsth..t..............tppp.slchLAccFscWFFshLNu.............-shu.pcFWsDssL+lphhss-tss-ph..puAptV.ptLlultpp.thhFNPNLspsGlpGph-saGhVlVhssGTlHpsppClGlFEpsFGLlRDP....hssNNWKhKpsclpL+upt	..................................................St.EhpGh+pLLt.hcs...splhuLscTlTsp.llp..spspp-AlcAILsYSpsscELL+R+KVpRElIFKYLuspulhlsPso-KpsLIp+shpaWppp..p.p...................hppsspss...ppp.....pp.p...pp..............................................................ptpphs.hppLuccFspWFFtlLNu.t...............spaGPpHFWpDspL+h..h..h..psu....-p.ss..ch....pGAp.Vuh+LluLspp-hlhhsPNLsspGl+st.ssHGLVhVtVsGTlHc.....s.s.......s.......C.LGIFEQlFGLlRsP....hhpNsWKIKhlplplhup.s...............................................	0	14	18	32
+14860	PF15009	TMEM173		Transmembrane protein 173	Eberhardt R	re3	Jackhmmer:Q86WV6	Family	Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA [1-4].	27.00	27.00	62.70	35.70	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.89	0.70	-5.62	16	77	2012-06-25 12:34:37	2012-06-25 13:34:37	1	2	63	7	51	89	0	271.20	37	83.39	NEW	chlpplsh......h..hh.thChhs.p.hppha.h.csphWpll+psashshpsshhhhuhllluhhhassssshssls.shhhh......hp................lsppsLoahlhl+psp......h...tls...sL....shAsGhAhSYaaGYL+LlLP........uLpcRhcpapcppN...hphss+RLaILlPp-shVsssl..p..ss..hlchtcsLpsphlsRAGlctRsY.KpuVY+l...tcctsspshhhshEhATPLlThach.pp..usshhh+E.+pE.hhhFh+pLc-lLp.....shPEo+spscLIhYssh.-sp.Gs.hsluclllp+lcpppc	.........................................................................hhhh.h.ls.llpt..h..C...ht.p..hpphp.h.psp..hhphhptshshs.tth....hhhl..lshhhh..h.phssh..s..h.hhhh.......................hhsphLshhlhlpt..t..............h...ph.tls..tsh....shApGhAaSYYhGYL+LlLP........GLptRIptY.pppps........hshss+RLaILlPhcshVsssL...p.sDs....slchhcpLsppphsRAGl+sRsY.pNolYcl....hcssppshhCllEhATPL.TLFsMspp..upuuhu+EpRhEQsplFhRpLc-ILt.....ssPEspspscLIlYp...-st.usphslup.lLpHlpppp................	0	11	14	32
+14861	PF15010	FAM131		Putative cell signalling	Coggill P, Hetherington K	kh6	Jackhmmer:Q96AQ9	Family	The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways [1]. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.	27.00	27.00	32.10	31.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.95	0.70	-4.66	5	167	2012-06-25 12:34:48	2012-06-25 13:34:48	1	2	38	0	87	138	0	229.00	44	79.80	NEW	VEDTluMLPKSRRALoIQEIAALARS...ShpGISQVVKDHVTKPTAMAQGRVAHLIEWKGWuKPsD.....oPpAl.cSDFsSYSDLSEGEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDso--SY-EDhusNa-ssoQpLhpst.....t.lhpsphsShPpphsSps..s.sSpss.E..hSs-oLsAS.sohs..........sp...hs........stpGuuup.uuphL...ts...tsGElpLA+uPsppcpsAh+tht....sscpDSssYssshoEouLSPtE-......Dptsh....ss..pEh.huachsR+VSDVoSSGVpShDE	......................................hLP+.+.Rs..shhtIuALA+S...SL.s...GIS...pshKDHVTKPTAMAQGRVAHhIEWpGWuKsss..................u.tsh.cp-hsuYSD.LS-GE+EAR.F.......AA..GVhEQFAIuEAsLhAWSShDGE-.s.s.sShp-s.hs..tt.p.......................p..hhps.h...shs.hp.su.t...s.sSpss.....sspolhuS.sshp..........................................t..s........h...........t....h.p......................................................................................................................................................................................................................................	0	4	13	36
+14862	PF15011	CK2S		Casein Kinase 2 substrate	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NX04	Family	It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterised. It is found to be localised in the nucleus and cytoplasm [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	27.10	27.50	25.50	25.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.87	0.71	-4.46	18	90	2012-06-25 13:10:52	2012-06-25 14:10:52	1	3	72	0	58	89	0	155.10	31	72.95	NEW	ppL+ptFpslcpppctWpuslscstsLluSLusLsEQLpAhpclphtss..LcsFPsLppRLptK.htAl-tlLscLsEcLspLpcVpcsluptlpsshplYcpph..ssLslssshpRuulsPSlADhLEaLQDl-RaYRppalp++.lLpsLshcsLsshpuhs+pW	..............ptl+ppF.hlccppshWpsshpcs.shlsuLusLsEQLpAhpslc....htsss.LpsF....P.sLp-RLhtKQht.......Ah-hlLspL.tEpLspL.pVpcslsptlcpshplhcpps..sslslc.slhptuulsPSlADhLEWLpDl-RaY+p.p.........Y..lp+c.lLssl.phs..sLsshpuh.pth....................	0	15	25	41
+14863	PF15012	DUF4519		Domain of unknown function (DUF4519)	Eberhardt R	re3	Jackhmmer:Q9NRQ5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between  and 59 amino acids in length. There are two conserved sequence motifs: KET and VLP. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	54.70	54.50	21.60	21.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.76	0.72	-4.05	12	70	2012-06-25 13:22:02	2012-06-25 14:22:02	1	2	63	0	47	63	0	55.60	62	84.22	NEW	MRQL+.GKsKETpKpK+ERKp-.hEhpp+lhTVVLPslushhlhIlVaVYLKTRPp	.MRQLKGp.spKETsK-KKERKpshpEu+QQIsTVVLPTLAVVlllIVVFVYlsTRP.....	0	10	12	28
+14864	PF15013	CCSMST1		CCSMST1 family	Eberhardt R	re3	Jackhmmer:Q4G0I0	Family	This family of proteins was discovered in a screen of Bos taurus placental ESTs. The B. taurus member of this family was named cattle cerebrum and skeletal muscle-specific transcript 1 [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 97 and 157 amino acids in length. There is a single completely conserved residue D that may be functionally important. The function of this family is unknown.	26.10	26.10	29.20	27.50	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.67	0.72	-4.06	15	66	2012-06-25 14:36:52	2012-06-25 15:36:52	1	2	57	0	39	66	0	74.40	37	49.36	NEW	scpPl+aooSpAu..+Wcsppohusspsc...PWapsalluhSlsshllYFCllREEsDlDptLc........psLh-c.l.uLEcpphp	...scPI+FSuSpAs........pWpspcohutsppc...PWapshslSsSLsshlla.ChLREEoDlDphLc........psLh-p.l.t.pp....t.........	0	13	15	26
+14865	PF15014	CLN5		Ceroid-lipofuscinosis neuronal protein 5	Eberhardt R	re3	Jackhmmer:O75503	Family	\N	27.00	27.00	33.60	53.90	18.50	21.50	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.13	0.70	-5.06	4	59	2012-06-25 15:14:48	2012-06-25 16:14:48	1	2	42	0	40	54	0	283.40	61	85.46	NEW	ppWPVPYKRF-FRPcsDPYCQA+YTFCPTGss...IPVMK--DlIpVaRLQAPVWEFKYGDLLGHhKIMHDAlGF+SoLTGKNYTMEWYELFQLGNCTFPHLRPsMsAPFWCNQGAACFYEGIDDsHWKpNGTLVhlupIS.GsMFNcMA+WVKpDNETGIYYETWTVpASP-tsSssWFDSYDCSpFVLRTYpKLh-LGApFs.KspTNYT+IhLYSGEPhYLGN-TSIFG.oGNKoLAhsIRcFYYsF+PHpSh+EhllSLLcIh-+Vllc+pFYhFYNhEYWaLPMKFPYlKlsYEEIPLP	............................WPVPY+.RFsaRPcsDP.YCQ.A..+YT.F..CPTGSs...IPVM+s-DlIEVaRLQAPVWEFKYGDLLGHlKIMHDAIGF+STLTGKNYTMEWYELFQLGNCTFPHL....R..P-...hsAPF....WCNQGAACFFEGIDD.hHWK....EN....GTLlhVATIS.GshFNpMA+WVKpDNETGIYYETWsVpASPp..+sAcsWF-SYDCScFVLRTapKLAEhGA-F.K....pI-T..NYT+..I.FLYSGEPsYLGNETSlFGPsGNKTLuhAI++FY..aPF+...P.HhSsKEFLloLLpIFDsV..Il++pFYLFYNFEYWFLPMKaPFlKITYEElPLP.......................	0	9	14	22
+14866	PF15015	NYD-SP12_N		Spermatogenesis-associated, N-terminal	Coggill P	pcc	Jackhmmer:Q9BXB7	Family	NYD-SP12, also known as SPATA16, is a germ-cell specific participant in the Golgi apparatus, and its expression is confined to spermatogenic epithelium, not being found in interstitial cells [1]. Computer analysis of the protein-sequence showed that NYD-SP12 contains a cluster of phosphorylation sites for protein kinase C as well as for cyclic nucleotide-dependent protein kinases [2,3]. It is postulated that since the mutation of some Golgi apparatus’ proteins are responsible for male infertility that NYD-SP12 might play a role in modification and sorting of acrosomal enzymes [3]. OMIM:102530.	27.00	27.00	27.30	36.70	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	569	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.15	0.70	-12.83	0.70	-6.28	3	107	2012-06-25 15:20:51	2012-06-25 16:20:51	1	1	36	0	24	105	0	196.80	46	99.32	NEW	MDSGsSRSLEsoVsRlY+DpLLPKINTSKKMSTLssuP...sILEsopEIKKNsG-tQVEsosERlKhTKoIKEKQSNDLEKAAhKRKAEuEEK.sGKKEAKIhELDNQLl.TsPLPHIPLKNIMDVEMKLVYlDEp-VuYEFApPsMspGpQsTsQsAphsDPsSs+shSsLPQIDKWLQVALKDASSCYRQKKYAVAAGQFRTALELCSKGAALGKPF-AaAEDIASIASFIETKLVTCYLRMRKPDLALNHAHRSIVLNPAYFRNHLRQAAVFRCLERYSEAARSAMIADYMFWLsGGoEcSISKLIKLYWQAMIEEAITRAESFSVMYTPFATKIKsDNIEKVKDAFTKTHPuYs-aIYTDsQGLHlLPQTsDWSSFPPQQYLLTLGFKNK-DGKFLEKlSSRKLPIFTEHKTPFSPLTREDTVRQMETlGKRILPILDFIRSTQLNGsFsACSGVMEKLHYASLLSRLQRVKEQSQVINQAMAELATIPYLQDISQQEAEL...LQSLMADAMDTLEGRRSDKERVWNpIQKVGpIEDFLYQLEDSFLKTKKLRTARRQKTKMKRLQTVQQ	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	3	7
+14867	PF15016	DUF4520		Domain of unknown function (DUF4520)	Coggill P	pcc	Jackhmmer:Q96MH7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.	27.00	27.00	27.00	27.70	26.80	19.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.89	0.72	-4.41	13	57	2012-06-25 15:24:44	2012-06-25 16:24:44	1	3	53	0	36	59	0	90.00	38	13.52	NEW	ushsssVlp-sslsGsGpFhAYoDG+VRshFsDRshLsLsh..pt...................spshscllhPDGppshlplsps...sshccY..VssAlpas+as	........s.hhslllp-ShIsulGRFhAYoDs+V+ulFhDthhLoLsashss................................shuhC+LshPDGppplIplp+P...tsac.RY..VssslpasRh.........	0	8	14	21
+14868	PF15017	AF1Q		Drug resistance and apoptosis regulator	Coggill P, Hetherington K	kh6	Jackhmmer:Q13015	Family	AF1q is an oncogenic factor involved in leukaemia development, thyroid tumourigenesis, and breast cancer metastasis. AF1q plays a critical role in the regulation of apoptosis and drug resistance. Initially identified as a mixed-lineage leukaemia fusion partner (MLL11) in infant acute myelomonocytic leukemia carrying t(1;11)(q21;q23) translocation. It is located in chromosome 1 band 21 [1]. AF1Q may be a novel mediator of metastasis promotion in human breast cancer through regulation of the MMP pathway and RhoC expression [2].This family of proteins is found in eukaryotes. Proteins in this family are typically between 25 and 482 amino acids in length.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.30	0.72	-4.08	10	164	2012-06-25 15:33:04	2012-06-25 16:33:04	1	8	61	0	89	141	0	74.70	26	19.11	NEW	+sspps..pssssppP-stEFSSFhFWRsPLPsI-c-LhEhL.scthssss.........stp-pc..................t-ccp--s-sDssGWITP.SNIKQIQp-	..............................t............t.p.ps.p.asSFhaWRsPLPsIDh.s..lE.hL.....h.sp....ps...........................ttcpp.....................................................................................................................................	0	8	16	38
+14869	PF15018	InaF-motif		TRP-interacting helix	Coggill P, Hetherington K	kh6	Jackhmmer:C9JVW0	Motif	This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron [1].  InaF is a protein required for TRP calcium channel function in Drosophila [2,3]. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types [3].  The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.	20.00	20.00	21.50	21.00	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.64	0.72	-4.50	26	111	2012-06-25 15:53:43	2012-06-25 16:53:43	1	3	57	0	78	107	0	37.50	40	22.29	NEW	spKhlRlhTVluYlhuVSLuAlhLolYYhFlW..ssshts	...pKhhRllTVh.sYlhuVShsAlhLulYYlFlW..-ssh.....	1	24	30	61
+14870	PF15019	C9orf72-like	FTDALS;	C9orf72-like protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q96LT7	Family	The precise function of this family is unknown but members have been found to be localised in the cytoplasm of brain tissue. Defects in the gene, C9orf72, are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexa-nucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci [1]. This domain family is found in eukaryotes, and is typically between 230 and 250 amino acids in length. There is a single completely conserved residue F that may be functionally important.	27.00	27.00	39.70	32.90	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.23	0.70	-5.12	18	93	2012-06-25 15:54:28	2012-06-25 16:54:28	1	2	61	0	64	77	0	237.90	45	51.15	NEW	p.ls+hsLus.hppppsthsshl.sphhplsppslhlhuhlF.h.spsspp...shauloll..lsppclpthhphhpslppphpplstph+thhpp.....................ppslpchss.ltphhp............hlsthhpsslhs..........hpItsoshs...............FhupsloSHLpTQhsolI.usshcpspphhshLuhFhhstphphSphphpss......hpssLaLQslpcpssss....hphllp.ppPhThIcLcpcpVhposshcppp	................................pFLAppTLssEIh..csupsssl-sKFaVLsE+ullllS..hIFsu.shsGc+...........sTYuLSlI..LPpoc.LuaYLPLHplCs-R......Lscll+K.sRlhhpK..............................pupslIsh...LTuEllslMc............LLuSh+oauVscc.........I-Is-TlLND-cIus.........psapsFLhpAISSHLQTsGCSVVVG..SssEc..VNKllcTLsLFLTPsER+CSRlsps-up.............pYpsGLFlQGLLK-uoGShshPhcplhhuPaPTTaIDlDhs.TV+QhPPpHEHh.....................	0	28	33	46
+14871	PF15020	CATSPERD		Cation channel sperm-associated protein subunit delta	Eberhardt R	re3	Jackhmmer:Q86XM0	Family	The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport [1].	27.00	27.00	32.60	28.20	18.50	23.70	hmmbuild  -o /dev/null HMM SEED	733	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-13.31	0.70	-6.52	7	107	2012-06-26 07:21:54	2012-06-26 08:21:54	1	4	32	0	57	111	0	504.10	29	86.63	NEW	.l.ss.hhhssstpclhtpsschp.shhhshplhLThs.hpss.lPhhlPhSh.sGsP.lsShch.suShlLLVsstcsa.hs.phpoWop.pu..c.lScsptc.................................................................sssaots.hhlshos.hFAhlpssph.ps.lhhSssushphpphpYstps..lusLhuhhphpohopsh.lllhspshtpapYpDasLshoh......cshLphhht.uthshLllWsc+slhhuhpshplstsVpshpGptsL.SSlscuslhhpslsss.s-lsVhhcpNslaYuplsI..oshlKhtt.s.aopcsslhFsssGplplLhslcD....uhsappshs.l.th..ssphphshC.h.hhpsphhsphYplDhsppLplhA.hl...shuLhslV.s.sP+.Lshpssl.aE.u....G.sp+pLsIphpQppcatpsDs.FpsphK+sslsslplc.ushphoCsshK.hsh.IuVGCD.pK+IslQs.phSuC.........LpcsaSYlIEK-hhc.....ppsSccLcVpYpapchGCPLhl.asp.a+PVVELac-sta.Ell-ApallhElpGh.sYoashThppusChspsQsWsohhc.sht..h..sWs.ENYhsCas.shspP.t..s.PYpILsupstN+llas.p+sGhYlFhlpIlDP.YSaCpLpThFul.saGhhPhs.h.hssshlhllhhhhholhl..................hshhhhpRhh	...........................................................................................................................h.........h.....h.............h..................................................................................h.........h....................h.h.hs.....t.h.h..t.....th.h..h.........t.hh.h.......p...hh......ptt...a...ph.h...s...........pt.h..hh..u.hs.hlhh.p.phh...pth.....h.h..t.......h..tt.hht.hh...s...phh..hhh..s.h.ha....phth..p.hhhh......s.p...shhhhptsG.h.hlhsh.s....hh...pph..h.th....s..tht.C.h..hhpsph...hahlDhtptLphhs.hl...shu.h.......l......l.s.sPc.Lt.ptph.aE.uh...G.sphpl............plhhhQp.pa...tthps.Fp.p.ppsshshlplc.sphth.Cs..p...sh.luVGCs.pKhIhlps..phptC...........hpc...sasalI-+.phhc.....pp.....pcs...lt...V.Y.hpphGCPlhl.asp.a.pPllpLacpsta.c.ltspallhElpGh.sYoas.Thtpu.hChppsQsWpohhp..p.t.........h..hWs.pNYhpCas.s.sts.h..s..YpIlstpst.Nplhas..t.sGhYlFhlpllDP.YSaCpLpshhul.shG.hs...h...h....hh..hh..hhh.hhh...................................................................	0	10	10	23
+14872	PF15021	DUF4521		Protein of unknown function (DUF4521)	Bateman A	agb	Jackhmmer:Q8IYI0	Family	This family of vertebrate proteins is functionally uncharacterised. The family includes the Chromosome 20 protein C20orf196.	27.00	27.00	67.40	67.30	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-4.73	5	40	2012-06-26 08:56:18	2012-06-26 09:56:18	1	1	28	0	21	29	0	170.30	61	98.08	NEW	MAoQEATPGSpSEESSsLDLPSVCDIRDY.lLQRPSQEosSEAFSSlEupShPsSSDVDPDoSNLNTEQssSWTSENFWLDPSVKGQsETKEEDDGL.....RKSLDRFYEsFuHPQPGSuNPLSsSVCQCLSQKIoEL+GQESQKYALRSFQMARVIFNRDGCSILQRHSRDAHFYPlcEGSoSL-DEKPTPGLSKDIIHFLLQQNVMKDp	..Msup-ATsuS.hSEES.S.sLDLPSsCDIRDY..VLQ+PSQEAsSEAFSSlEhaShPsSSDVDPDoSsLNsEQss.SWsSENFWLDPusKGQsE.ppEDDGL.....RKSLD+FYEhFGpPpPuStssLSASVCpCLSQKIopLcsQESQKYALRSFQMApVIhsRDGCollppHs+-s+FYP.t-Gssul-ccc.sPGLSc-llpFLLpQshhKc.......	0	2	2	4
+14873	PF15022	DUF4522		Protein of unknown function (DUF4522)	Bateman A	agb	Jackhmmer:Q96KX1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. In human this protein is known as C4orf36.	27.00	27.00	34.70	33.20	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.67	0.71	-4.38	3	26	2012-06-26 11:36:54	2012-06-26 12:36:54	1	2	18	0	11	23	0	97.20	68	81.83	NEW	MAYGLPRKNTVKTILRGSCYKVQEPWDLALLTKTWYTNLANIKLPFLEEIoFGSPVpLpKspTpK-spLPSAESIKLEREYEsKRLsKLKCQENVuKEIQhSLRERPVGLRRPLPPK	MAYGlPRKNTVKTILRGSCYNVQEPWDLALLsKTWYoNLANI+LPFLtEIsFGuslpLpKspThK-uLLPSAESIKLEREYEhKRLscLKsQENsucEIQh.LRcR.sGLRRPL.sK..............	0	1	1	1
+14874	PF15023	DUF4523		Protein of unknown function (DUF4523)	Bateman A	agb	Jackhmmer:Q7Z4U5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals.	27.00	27.00	29.10	36.10	26.70	24.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.13	0.71	-4.73	4	34	2012-06-26 11:58:47	2012-06-26 12:58:47	1	1	22	0	14	28	0	139.70	58	77.70	NEW	NLHKLLPN+LMElLaSa+SEEDK+KCENsEFSGLERILtRHQhPKEINLTPKPSpMPLW+RKh.NNhspGWKKC+LWsKsTKEPPMSTIVVRWLKKNMQPoEDLcSVhpRLSsFGPIpSVTlCGRQSAVVVF+DhsSACpAVoAFQSRsPGoMFpCuWQQRFMSK-	......................................NLHcLLPN+LhEhLaSh+SEEDKcKCE.NPEhSGLERILARHQLPKEINLTPKPs+MPsWKRKIINNlo-GWKKCHLhc+NhKEPPMSTIVVRhL.pKNh..pcsL..+sl.p+LpthsshtpsT.sG+ppshV...................................................	0	2	2	3
+14875	PF15024	Glyco_transf_18		Glycosyltransferase family 18	Eberhardt RY	re3	Jackhmmer:Q09328	Family	Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme [1].	26.00	26.00	26.60	26.20	25.20	24.30	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.84	0.70	-6.17	11	229	2012-06-26 12:02:26	2012-06-26 13:02:26	1	8	75	0	150	195	2	376.20	35	73.28	NEW	CYA.-aGVD.GS.CSFllYLSEVEsaCP.h.tRt+ps.....s.......pp..sslRcslt.L...h...pcsphpah+pRIpRhWspWlpAucp.Lpc.ppshppR++h+lLValGhLusEsuh+huppuhpGGPLGELVQWSDLluoLplLGHpLclSsspspL+ulls.hhstspssssssscpphDLIaTDIhGLs.h+pphs.hhh.pa+C+lRlLDSFGTEs-FNhpsYspppsh......ppp..WGuasLphpQahTMFPHosDNoFLGFVV-pcs...........ps.++pspul.....VYGKctYMWc..spcchlcllp+ahclHATVss.tp.....pslPoh...VpNHGlLsupElppLL+csKlFlGLGFPYEGPAPLEAlApGsVFLNsKFcPP+SRhNpcFFc-KPTlRclTSQHPYsEtaIGcPHVhTVDIsNpc-lEtAlKcIlphK.lcPalPaEFTspGMLpRVsshlpKQsFCsp.s...................pWPPlsAL+lhtuspup.SCcpsCpspsLlCEPoaFPhINsppthp+...phsCsuscspss..lAPuh.....sCslQussLLFSCAussP...phpRlCPC	.............................................................................................................................................................................hhh.Rh.th.........Wh..u....ht............................thplhhh.t.h..t......h...s.pGGPLGEhlQWsDl.ssL.hlGHtl.hs.p..ph.........................hhh.Dh.G...hpt.....h.......pC.hRllDoFGTcstash..h............tt...aG.hshp..Qa..ThaPHo.s.D..N.oFhGFl.pp..................p.ht..ullYGK.t..h.a..p.......sp......p......h.....lthl....pp.h..h.plH...uTV.....t..........hPsh....lpNHGhlst.-h..LLpcs.+lhlGhGFPhE.GPAPlEAlu.Gs..hFlps...chp...s.csp.s.thh..................tK..Ps.R.c..h.SQpP.Yhp.hlG..PaVhslshps.tthctslpthht..p..h.................p....PahP....h.....EaostGhLpRl.thhlpp.p.....h...............................................aP.Ph.ps.lph.hhu.....up.uC.psC..ppthhC-PshF.hlNppp.h.p...hth...Cps.......p.............................p....h.............hP.........t...........ttChh.p...tp..l..aSCsutt.......phpRlCPC................................	0	54	67	108
+14876	PF15025	DUF4524		Domain of unknown function (DUF4524)	Coggill P	pcc	Jackhmmer:Q96MH7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.	19.50	19.50	19.70	19.50	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.81	0.71	-4.73	7	59	2012-06-26 12:02:50	2012-06-26 13:02:50	1	3	49	0	40	58	1	132.60	45	25.25	NEW	phllhsD-pVpspasDGspLpLSPCGStFlhEptss.stHPLptscpl+QRT+FslSpa+pplhpAL-FRNpasspPaLsppllpsE....Rptphhscloclc.WPssssss....hpstpsGpVploSlDGhApLhLsppQcEFTVcFlC+lup	......................................Mlla-D-SVpVpYhDG...opLpLSPC....GoEFlhc+sss.u............sHPl.ptscRlRQRTcFslSsa+ppl.pAL-FRNp.us......p.P.a.LspplIss.-...............+Kp.....p.lhhc.....hoEsc.WPs.ssss...........thhh...hpsGpVcIsSlDG+AhLsL.spsQcEFTVcFLCKlSp................	1	8	13	23
+14877	PF15026	FAM74		FAM74 protein	Bateman A	agb	Jackhmmer:Q5TZK3	Family	This family of uncharacterised proteins are found in humans and are known as FAM74 proteins. Members of this family contain several short protein repeats.	27.00	27.00	31.40	48.50	25.10	22.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.11	0.71	-4.50	2	11	2012-06-26 12:07:12	2012-06-26 13:07:12	1	2	3	0	8	9	0	84.70	64	100.32	NEW	MWRELRGCPGGDVETAQRLSQRRRGKSSEAVPEKTWRAQRMSQRRRGESSEAVPEKTWKELRNSETVPEKTWKQLRtCLQEDVpRVQRLShhhHhts.hhlhhth.hp.pGs+..ssTaL...hhht	........cLRsCPGtDhETAQRLSpRRRGcSSEAVPEKTWRsQRhSQpR..cSSEsVsEKTW+p...SEsVsEKoW+pL+tC.pEDVpRVQRLS.hhHhts..hlhhth.hp.pGs+..ssTaL...hh....	0	8	8	8
+14878	PF15027	DUF4525		Domain of unknown function (DUF4525)	Eberhardt RY	re3	Jackhmmer:Q09328	Family	This domain is found in eukaryotes. It is often found at the N-terminus of glycosyltransferase family 18 enzymes (Pfam:PF15024). It is also found in coiled-coil domain-containing protein 126.	27.00	27.00	63.10	62.30	23.90	22.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.68	0.71	-4.64	7	96	2012-06-26 12:10:43	2012-06-26 13:10:43	1	3	41	0	56	75	0	130.60	64	31.53	NEW	shshshK..SQKLuhhLlsFGhIWGhMLLHaThQp.sp+pSSspLRpQILDLSKRYlKALAEEN+slMDGs.uuoMsuY.DLK+TlAVLLDsILQRLsKLEsKVD.llsNGousNhTNuTusshsslsssc+sssuuslp	...............hhhhshK..SQKLuhhLlsFGhIWGhMLLHaTlQQ.spppSSuhLREQILDLSKRYlKALAEEN+Nl.VDG....s.uusMsuY..DLK+TlAVLLDsILQRlsKLEu...KVD.lVlNGousNoTNuTo.slss.lss.c+lNsus.I........................	0	5	8	21
+14879	PF15028	PTCRA		Pre-T-cell antigen receptor	Bateman A	agb	Jackhmmer:Q6ISU1	Domain	The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation [1]. This protein contains an immunoglobulin domain [1].	27.00	27.00	31.40	67.40	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.07	0.71	-4.65	3	29	2012-10-03 02:52:13	2012-06-26 13:13:27	1	1	19	3	13	51	0	146.70	75	63.73	NEW	GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLDSsIWFSAGNGSALDAFTYGPSPAsDGTWTSLAQLSLPSEELAAWEPLVCHTGPGAGGhSRSTQPLQLSG.EASTARTCPQEPLR...............GTpGQsLRLuVLRLLLFKLLLLDVLLTCSRLC	.........GVGuTPFPSLAPPITLLVDGKQQhLVVCLVLDVAPPGh-SPIWFSAGNGSuLDAFTYGPSPAsDGTWTuLAQLSLPSEELAuWEPLVCHTGPGAtG+SRSTQPLQLSG..EASoARTC.hEPLR.................Gh.utsLhLGsLRLLLFKLLLhDlLLTCS+L........	0	1	1	1
+14880	PF15029	DUF4526		Protein of unknown function (DUF4526)	Bateman A	agb	Jackhmmer:Q8WUU8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals and includes the human integral membrane protein TMEM174 protein.	27.00	27.00	175.40	175.30	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.83	0.70	-4.78	5	34	2012-06-26 12:24:07	2012-06-26 13:24:07	1	1	32	0	23	31	0	233.20	66	96.34	NEW	-DFulNVFSVoPYPu.SpSDupVSDGDKAGATLLFSGIFLGLVGITFTVMGWIKscGpoHFEWTQLLGPILLSVGVTFlLISVCKF+ML.SCKPCKpoEEss...LDhEQoSuGQSFVFTGINQPITFHGATVVQYIPPPYuopDssGGso....PllSNsNulaSuau..sssusGPPQYYsIYPMDNPAFVpD-ssPupluts-....lcsSpPDAuhp-E-tLGsscosEhSPPuYEEIFPTsR	.EDFPlNVFSVTPYTP.STADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKML.SCQhCKESEERl....Do.EQTsGGQSFVFTGINQPITFHGATVVQYIPPPYuSpEPhGhsosYLQsslsPCGLlsSGGA..sushPSPPQYYTIYP.DNuAFVsDE.shPuas.suus.....cRsssDAcpLE.EspL.t--.ssssFSPPPYEEIYuls.p..	0	1	2	7
+14881	PF15030	DUF4527		Protein of unknown function (DUF4527)	Bateman A	agb	Jackhmmer:Q6ZRC1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates.	27.00	27.00	33.40	33.40	26.90	23.80	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.79	0.70	-5.09	5	28	2012-06-26 12:29:08	2012-06-26 13:29:08	1	2	22	0	14	26	0	239.40	52	67.78	NEW	QLRDsEA-soEEDLRLRVQQL+HQVLTLQCQLRDQsuAHRtLQAuh-EATsLQDcLQuKL-ELQKKQHEANLAVoPLKAKLASLVQKCRERN+LITHLLQELHRHGluNHLLSEhAQuMVsDVALAEYAATFLAPGlPETSHH..LDVESEcTAsc+A.QKYLLNPEtDSV..LQssLpSESWPlPEAEWPAQTApLDS.hKLPLPSGsTPsPGTC.AuVAVEPuLPAQsL+EcGGsSCPl.LpADsLPPPsELLSPARILAFHQELRQSICSNSQVNKSPLE	................................................pDsEApssEE-.RLcsppLHHpVLTLQCQLRDQuuAH...QAuh-E.As+LpccLpscL-ELQKKQHEApLAVTPLKAKl.ASLVpKCpERN+LITHLLQEL+RHGhsNhLLSElAQsMlsDVALAEYuATFLuPGlPETSHH..LDVcSEhTAshRA.QphLLNPchDSV..lQpshpSEShPlPcsEWPApsApL-S.lK.LPLs.ssT.DPGsC.AusssEsGLsAQpLQEcGGhsCPs..LpssslsssSELLSPARILAFHpELRQSICSNSQVpKSPLE...................................................	0	2	2	2
+14882	PF15031	DUF4528		Domain of unknown function (DUF4528)	Eberhardt RY	re3	Jackhmmer:A6NNL5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 95 and 154 amino acids in length. This family includes Human C15orf61.	27.00	27.00	38.50	38.50	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.83	0.71	-4.38	13	65	2012-06-26 12:31:18	2012-06-26 13:31:18	1	1	59	0	42	60	0	119.40	64	85.25	NEW	KPtASEVLTuaL+QRscPsWTSYFV+YpcVtNDQaGhSHFNWsV.sGsNYHILRTGCaPaIKYHCT+RPhQDLohEDpFFphlKllNLGlPsLhYGlAAhhLI+HpEhVcsuc..GsVsIYFLhcED+G	...............+PpASEVLTpaLhQRphP.WTSahV..YusVpNDQFGhSHFNWsV..pGuNYHlLRTGCFPFIKYHCSKtPhQDLuhpD+FFpsLKVlNLGIPsLhYGLuuhhhh+hTEhV+TSh..GPVTlYFL.KEDcG......	0	10	14	29
+14883	PF15032	DUF4529		Protein of unknown function (DUF4529)	Bateman A	agb	Jackhmmer:Q6P387	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.	27.00	27.00	43.80	43.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.48	0.70	-5.87	5	37	2012-06-26 12:32:13	2012-06-26 13:32:13	1	1	27	0	20	36	0	334.60	49	98.13	NEW	MDL...CpKsET-LENuENsEI-SoEETELTYTCPDERSEKNHVCCLLslSDITLEQDcKApEFlIuTGWEEAVcGWGRTSPTACIWPRKKsKKARVGEuAs..SsCLLCssLSpGSLEuRP.opuuK......AEsGPEKDpGSsSQTpusPQGPosASRE.INKICFPTYhpGEKKSLQIKEFIWChEDWAoPETlRGKssRsPSpGscphLSISDuLTSRALLVLPPLKuSssNuLDVLGKKSKNhFLQPEEKVLuVEKDECVAhsYGLKoVDGKGEKpssELA+Hs+VsDhhPFPPsVApTsLL.A-sEpCCLHWSLLPEKNLlCPPsPoNl+YLATlQLLQKQGsQNYKA+hKA+EPRPPhpTpK+lLTEAKQENRPQMLETKVFPRPLLPSLTVSRVVIPVSTHRlL	....MDl...CQKsET-LE.tcssEIppsEETp..ohTCPDt+SE+sHVhCLLslSDlTLEpDp+A..pEFhIGTGWEEA....VpGWG+sSPsACIW.P.RKpsKKu+sGEus...SsCLlChsLsp.....ho...h..-s+P.hps...............sspcspuossphpusstu.tsuSRt..hsplshPs.hpuEKKSLQlKEFIWC.ccWshPpo.+s.Ks.ts...sstsspp.t.ohsssLoS+ALLVLPPLKuS..NsLDlluKKo+s.hhpsEEKshsVcK-tshuts.GhKos-GKGEKR..E.....LApH.hVsDh.s.PsssApTsLL.scsEpCCL+WSLLsEKshhsPPs...s...ssl+YLAsLQLLQKpGhQsaKs+h+A+-PRsPh.opK+hh.cAKQEsRPphLEoKVFs+PLLPSLTVsRVlIPh.sHRhL...........................................................................................................................	0	1	2	5
+14884	PF15033	Kinocilin		Kinocilin protein	Bateman A	agb	Jackhmmer:A6PVL3	Family	This family of kinocilin proteins is found in vertebrate. In mouse it has been shown that this protein is expressed primarily in the kinocilium of sensory cells in the inner ear [1].	27.00	27.00	34.50	34.30	22.90	19.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.60	0.71	-4.60	6	31	2012-06-26 12:53:32	2012-06-26 13:53:32	1	2	22	0	16	38	0	105.50	75	99.54	NEW	MDIPISoRDFRCLQLACVALGLVAGSIIIGVSVSKAAAAVGGIFlGAAGLGLLlhA.YPhLpu+FphshlhPsI.........GsLRIHPpsGPDHGEGRSSsNuNKEGARSuLSTVoRTLEKLKPGGRGTEEG	...MDIPIS.oRDFRCLQLACVALGLVAGSIIIGlSVSKAAAAhGGlFIGAAuLGlLlhA.YPFLKARFNLDHILPsl..........GsLRIHPpsGPDH.GEGRSSsNGNKEGARS....SLSTVoRTLEKLKPGs......RGsEEs....................	0	1	2	4
+14885	PF15034	KRTAP7		KRTAP type 7 family	Bateman A	agb	Jackhmmer:Q8IUC3	Family	This family of keratin associated proteins are found in vertebrate.	27.00	27.00	123.30	123.20	21.10	17.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.17	0.72	-3.34	5	24	2012-06-26 13:00:44	2012-06-26 14:00:44	1	1	19	0	12	27	0	85.90	84	100.00	NEW	MTRFFCCGSYFPGYPCYGTNFHGTFRATPLNCVVPLGSPLNaGCGCNGYSSLGYuFGG.SNFsNhGCCYGGSFYRPWGSGSGFGYSTY	MTRFFCCGSYFPGYPsYGTNFHRTFRATPLNCVVPLGSPLNaGaGCNGYSSLGYuFGG.SNFsNLGCsYGGSFYRPWGSGSGFGYSTY...	0	1	1	2
+14886	PF15035	Rootletin		Ciliary rootlet component, centrosome cohesion	Coggill P	pcc	Jackhmmer:Q86T23	Family	\N	25.10	25.10	25.40	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.00	0.71	-4.30	29	212	2012-06-26 13:02:07	2012-06-26 14:02:07	1	5	88	0	120	189	1	174.70	35	10.71	NEW	++Rl-AspEpQccpAsLhutLQpK.....ltpY..Rp+hu-lEppl....................ssp..........+.sccphshslcc................................hls+LEEEcpRs-p.......LR.ph-ptphpNppLps-lp+Lpppapt...plppKEchappcEcshspYlssEpp+.hhsLWp-lppVRRQhuEh+spTERDLpp.+sEas+ss+sl	...............................................++Lps.pEuQpcQApLVp+LQuK.....lhQY..+..p..hCt-LEppl............................................................................ttp...t....p..hpstpc...sL-p.......................................................................................................hLhRLEEEpQ..RspsLspVN..s.LRtph-puphsNcuLpcDlpKLTs-asphpcELtp+E.spap..pEpct.....ap.sYhp....sEHsR.LLtLWRpVVshRRph..tEh+ssT-.RDLtch+sEhsRhutp.............	1	24	33	72
+14887	PF15036	IL34		Interleukin 34	Bateman A	agb	Jackhmmer:Q6ZMJ4	Domain	\N	27.00	27.00	161.00	160.70	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.31	0.71	-4.70	5	39	2012-10-02 01:28:15	2012-06-26 14:07:47	1	1	27	13	17	42	0	160.20	69	72.21	NEW	GLElWslAus-ECulTGaLRDKLQY+NRLQYMKHYFPINYRVuVPYEGVLRsANITRL.....p+ApVSpRELRYLWVaVSLsATEpVpEVLLEGHPS.WKYLpEVcTLLccVcpuLu....pDVEls.P+VEulLoL...LopAsG.Sl.KLVRPKALLDNCaRVMchLassCC+pSSl	.........LEhWPLTQs-ECslTGaLRDKLQYRNRLQYM........KHYFPINY+ISVPYEGVhRlANlTRL.....QRAcVSERELRYLWVLVSLSATESVQ-VLLEGHPS.WKYLpEVpTLLLsVQpuLh.....DVEVu.P+VEuVLSL...Ls.APG.sL.KLVRPKALLDNCFRVMELLYCSCCKQSS.......	0	1	2	4
+14888	PF15037	IL17_R_N		Interleukin-17 receptor extracellular region	Eberhardt RY	re3	Jackhmmer:Q6ZVW7	Family	This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain [1]. Human putative interleukin-17 receptor E-like consists only of this domain.	27.00	27.00	28.40	28.00	24.50	23.80	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.55	0.70	-5.48	7	139	2012-06-26 13:28:15	2012-06-26 14:28:15	1	5	37	0	62	140	0	299.40	33	61.25	NEW	sluC.h....pT+C.Ls.Rhssphssputh...c...t.....cs.h..................pGlpsuhhphhV.tShpua.hthCthachsssAphplhup...Sptut+hsshpsslup+shhop+TQPs.scsh.......SQ+ptsP.................cauasl.s-scslpVTls...susEhslRLCapWslpCp-hupPhss.K.loGs+sVsLsYphLLPCLCIEu..Lp.DoVRpchCPFps.PcAahp-hWcuh+asshSt...hVhtLshhCPLKlcAoLC.Rps.to.CcsLssAhupEu...-thhlhptVDhHPpLChKFShtsuoalcCPapss..ohssWsssMshpspQhhLchSShstssFSuuhshPt.u.st.h.ss..hSpspsps.Pssh-LllshL+sGsCl.VWRsDV.FuhhtL.Cs	.............................................................................................................................pt...p.s.hph.s.........thChhhch.ssut.hh..up.....s.tshhhsshpsslupcshhhphTpPphtcth........s.ppthP.......................a.hsl.s-ucslpls...ls...su.-.phtLsh.W...psps.spPhhh.+.lousptlsLsap.LlPCLCIp.s.h...h.p.....DslR..pphCP..Fpp.....scAa........ps.............hWcsschp.ho.........shthps.Csl.s.csuLC.pts...ts...CpsLsssht..ps...pthh.h.hlchHPpLCh.phs..p..p.p..lppsh.ts....shs..shpssh.h.......p.tohh.ht.Ssshs....................o...s.s..h.hp..lh...t.t.C..h.................................................	0	3	6	22
+14889	PF15038	Jiraiya		Jiraiya	Eberhardt RY	re3	Jackhmmer:A6NGB7	Family	Jiraiya inhibits bone morphogenetic protein (BMP) signaling during embryogenesis [1]. The human member of this family is TMEM221.	27.00	27.00	33.30	28.20	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.09	0.71	-4.85	11	78	2012-06-26 14:47:06	2012-06-26 15:47:06	1	3	63	0	58	82	0	135.70	31	46.85	NEW	LsuLuLLsllSllhAlLSLIhLL+lpssstpstt.hhtstt.th.ss.....-thhhlY-lohALsALuLoLNLsCLLVCAlQhhFAs+llRus.sssuRs.....spaLtcSpssRpsAluuFFluIsVaLoulhLYohlpFcspPuIsoShllGsGllF.......CsuuMlHslalWp+tcspuh+phshs	......................hhhhsl.uhlhuhluh.hlhphps..ht.....................t.h.hlh.lshsLsuLsLsLslsslllsslphhhsschh+s......tRs..................shaL.cs.ph.RhsAluhF.hhulsVaLsul.lYs.hl...Fc.psuhssu.llGsGhlh.......h.sssh.sHslhhht+tpp.uhpt...s.................	0	14	20	42
+14890	PF15039	DUF4530		Domain of unknown function (DUF4530)	Eberhardt RY	re3	Jackhmmer:A6NGS2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically around 140 amino acids in length. The human member of this family is C19orf69.	27.00	27.00	77.20	130.50	23.20	21.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.59	0.72	-4.16	4	23	2012-06-26 14:53:34	2012-06-26 15:53:34	1	1	18	0	9	24	0	111.20	69	85.98	NEW	MELW+QL+QAGLVPPGLGPPP+ALRtVPPVtpsGQTLhSsGADTGGAREpLLWIWEELGNLRRVDVQLLGQLCSLGLEMGsLREELVTlLEEEEEppppEEcp......tPEcKQE	..MELW+QL+QAGLlPPGLGPPPpALRtlPPs-pPGQTLhouGADsGGARESLLWIWEELGNLRRVDVQLLGQLCSLGLEMGALREELVTILEEEEEsscEE.EEs.....ppsppKQ-.............	0	1	1	1
+14891	PF15040	Humanin		Humanin family	Bateman A	agb	Jackhmmer:P0CJ71	Family	This family of proteins is found exclusively in humans. Humanin is a short anti-apoptotic peptide that interacts with Bax [4].	27.00	27.00	43.70	43.50	24.20	17.70	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.62	0.72	-6.71	0.72	-4.70	9	21	2012-06-26 14:56:28	2012-06-26 15:56:28	1	1	4	2	11	26	0	24.00	75	97.68	NEW	MAsRGFSCLLLSTSEIDLsVKRRh	MAsRGFSCLLLssSEID.LssKRRh.	0	11	11	11
+14892	PF15041	DUF4531		Domain of unknown function (DUF4531)	Bateman A	agb	Jackhmmer:A6NCJ1	Family	This family of uncharacterised proteins is found in mammals. This family includes the human protein C19orf71.	27.00	27.00	85.80	85.80	18.10	17.50	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.23	0.71	-4.52	3	25	2012-06-26 14:58:44	2012-06-26 15:58:44	1	1	20	0	15	25	0	164.20	65	88.51	NEW	PcsLYSDDYLSLEGPRWsPAIRQAVRWKYTPMGRDAAGQLWYTGLTNSEoREAWYsLPRALDSPYREAYsRWHGCaQ+RERoMPSAYTQHLRETAWaDPlIPAQYpsPSTRWGSTLWKDRPIRGKEYVVNRNRYGVEsPWRuSDYVPhLSAPQRPRaTTQsYRQWGLEPYCPSTsQRPPPuaTP	....PsPLYSDDYLSLEGPRWsPAI+QATRWKYTPMGRDAAGQLWYTGLTNS-spEAWYsLPRA.sSPaREAYsRWHGCap+RE+ohPSAYTQ+LRETAWaDPllPA.QYhsPSTRWGShLWKDRPIRGKEaVlNRpRaGlEs.WpuSDYVP.LSsPQRP.hTsQsYRpWsLEPYCPSTsQts.P..TP.....................................	0	1	1	3
+14893	PF15042	LELP1		Late cornified envelope-like proline-rich protein 1	Bateman A	agb	Jackhmmer:Q5T871	Family	This family of uncharacterised proteins is found in mammals.	27.00	27.00	60.80	30.30	26.70	25.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-11.23	0.72	-11.72	0.72	-3.87	3	23	2012-06-26 15:02:28	2012-06-26 16:02:28	1	2	18	0	11	14	0	85.90	71	91.06	NEW	MSSDDKsKSuDPKNEPKNCDP+CEQKCETKCQPSCLKKLLQRCSEKCsh-KCPsPPKCsPCPPCPP.........SsPssPhCPP.CsPPCPuP...CPPSCPPKPCVKPCPPKCPS....PCPPPE	.MSSDDKsKSs-PK....sEPKNCDP+CEQKCEoKCQPSCLKKLLQRCSEKCPREKCPsPPKCPPCP.s..ss.........................Cs..Cs.....CP..CP........................	0	1	1	1
+14894	PF15043	CNRIP1		CB1 cannabinoid receptor-interacting protein 1	Eberhardt RY	re3	Jackhmmer:Q96F85	Family	This family of proteins interacts with cannabinoid receptor 1 (CNR1) and attenuates CNR1-mediated tonic inhibition of voltage-gated calcium channels [1].	27.00	27.00	28.40	30.10	25.70	17.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.93	0.71	-4.96	11	73	2012-06-26 15:23:00	2012-06-26 16:23:00	1	1	58	0	49	64	0	150.20	52	97.72	NEW	Mus....hstlh+lolSL+hpPssuPVFaKVD.GpRFuQs.RTIKLLTsSpY+l-VshKPush..pshulGGsslsLEp.po+..DtppsVYou.asT-GlssoKSG-RQPlplslpFsshGthcss.......hQsKaYshpcp-H....CpWGsshpsIEaEC+ssEsRolhhl.........pKEsF+	................Mu-lPsll+loluL+hpPN-GPVFaKVD.GpRFGQ...........s.RTIKLLTGSpYKlEVplKPsTlp..sp..sluIGGlhlPLE.+o+...DspplVYoGhYDTEGVssTKSG-RQPlQlsh.FschGsFETs.......WQVKaYNYcKR-H.......CQWGssFssIEYECKPNETRoLMWlNKEoF.h.............	0	10	14	33
+14895	PF15044	CLU_N		Mitochondrial function, CLU-N-term	Coggill P	pcc	Jackhmmer:Q96NS8	Family	CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organisms.  The function of this domain is not known. It family is found in association with Pfam:PF13236.	22.60	22.60	22.60	22.60	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.42	0.72	-3.82	51	327	2012-06-26 15:24:58	2012-06-26 16:24:58	1	45	226	0	243	326	1	76.20	35	5.87	NEW	lss..p-plp-l+phLhpt..sposhhTsapL.p..h..c..G.tp......l.scas-lspltsl.......ps....ss....p..Lpll..c-..sYsp.+pAchHlpRlR-ll	................................................ssp-pVp-l+QhLh-p.ssTsahTsFsLp.h..c..Gpp........L.ccasElpslpsl...................pt........ss....pLplV...........E-PY.Tt.+-ARhHVp+lR-Ll.........	0	60	122	197
+14896	PF15045	Clathrin_bdg		Clathrin-binding box of Aftiphilin, vesicle trafficking	Coggill P	pcc	Jackhmmer:Q96F83	Family	Aftiphilin forms a stable complex with p200 and gamma-synergin. This family contains a clathrin box, with two identified clathrin-binding motifs.  This family of proteins is found in eukaryotes.	22.50	22.50	22.50	25.00	22.10	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.52	0.72	-4.47	36	120	2012-06-26 15:31:09	2012-06-26 16:31:09	1	2	65	0	69	134	0	73.40	46	10.68	NEW	EhhcVWspLQDlcsuauLRYQWuuSHSNKpLLsSLGIDoRNILFoGsKp.......pslhVPhaAAGLGM..LEPTKtslc.P	...t..hclWppLQDIcsApuL+YQWuuS+ss+pLLsSLGIDoRNIhhoGsKt.......pslhhPhaAAuLGh..LEPsKt.lp..s......................	0	12	17	38
+14897	PF15046	DUF4532		Protein of unknown function (DUF4532)	Bateman A	agb	Jackhmmer:A6NCN8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	52.20	37.60	22.60	19.00	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.77	0.70	-5.41	5	36	2012-06-26 16:18:15	2012-06-26 17:18:15	1	1	29	0	24	26	0	228.90	52	89.88	NEW	MVHApEoLPTsQTWAQREFLLPuEopEaPGFTpQAYHQLALKhPPCT-hKuKVRQRLhpPWKDAAQHTWGFHTWLDVGRLPATFPTRPDRPYDSNVWRWLTDScAHRpPPAEPPIPPPSWMGQNSFLTFIsCTPIFVDhNRKKQVIlRTVKELKEVEKLKLRSEARAPPLDAHGNILPPKNFKKYRHISAGGRaEPQGLQLMPNPLPNNFARSWPCPNPLPHYQEKlLKLALLPSAPLSQDLVRsYQTLIEsRVALPLHHLS+ApPGKTssRKhKRRPG	.................MhpApE...s.pTWsQR.EFhLPscohchPGFT.QuYHpLALK.PPsT-hKScVRpRLhpPWKsu..s...p..H.TWGFHTWLDVGRLPATFPoRPD+PYDSNVWRWLTcop....AH+pP..........P...........uc...P..I..PPPSWMGpNSFLoFIpstPlFl.DhpRKpQVIhRThKEL+E..lEKLKLRSEuRAPPLDupGNIlPPtsFKK...ahss..................................................................................................................................................................	0	5	6	9
+14898	PF15047	DUF4533		Protein of unknown function (DUF4533)	Bateman A	agb	Jackhmmer:A2RU48	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. This family includes two human proteins: C12orf60 and C12orf69.	27.00	27.00	52.20	52.10	25.70	25.50	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.35	0.70	-4.93	4	54	2012-06-26 16:22:02	2012-06-26 17:22:02	1	1	28	0	35	55	0	208.40	41	92.27	NEW	c+pcLlpht+phF.pMpD.hphTNpLhElhNuphsspItpIpMKEDusVK-sh-.Ilphh+ElQstlpthpspMpcc........h.sohhcK.pslKEhpppthtlh+pVhosllspshsoush..lKhLpSSLohlhhs.lhsL............tp.uuol.tuhSsus.tlGhs.IL+tl.sAlcpsplpssl+Sht-pLtphhcs.c.hhchlpcshsTlc	.c+pcl.phtpphh.plpD.hssTNpLs-lhNtphssplh.lphKc-uoIK-sh-.l...lpshpchQptlpphc-slpcc............h.solhcKhpslKEhcppthslhppVhosllspAhsuush..lchltSslophhh..lhslh..............tp.u....so.htShus.us.thshc..hl+tl.sAlcppphpssI+ShtccL.phhpA.c.hhcslpcshpTlc.......	0	2	2	8
+14899	PF15048	OSTbeta		Organic solute transporter subunit beta protein	Bateman A	agb	Jackhmmer:Q86UW2	Family	\N	27.00	27.00	39.00	37.80	26.70	22.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.64	0.71	-4.05	9	37	2012-06-26 16:25:08	2012-06-26 17:25:08	1	3	31	0	24	34	0	122.30	45	82.98	NEW	-HSpssptAsssshVPQEL.......................LEEMLWaFRsEDAoPWNYSILsLusVVslISFlLLuRSIpANRNpKhp....ss-KppPEs.pLs-u.h+-sssLshLRET..LLSEKP...sLAQ.............sEhElcp+Dssh.shLsDP	.........................pt.pss.tsssussVPQEL.......................LEEMLWFFRsEDAoPWNaSILALusVVlhlShhLLuRuIpANRpcKhp........s.-KpsPEshphsEu.....t.h......+.-csuLss....LcET....LLSEKP...sLsp.............sphELK-+Ds...shhs-..........	0	1	1	6
+14900	PF15049	DUF4534		Protein of unknown function (DUF4534)	Bateman A	agb	Jackhmmer:Q8N7C4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.	27.00	27.00	73.40	73.10	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.93	0.71	-4.61	10	43	2012-06-26 16:29:12	2012-06-26 17:29:12	1	1	23	0	28	31	0	158.00	42	85.33	NEW	u+MhSlLsGlFSllsTp.aLIFEhpalsphshp-phshYpsTpshltsallsaphsIshsLShlTIllSCFLLYslasphYhGLLhYslWIlhYEhlNhsl.lLTNs..cpphKElphL+Whh.lSRhlLHhFhL.FVlpHAYhlYKspppssllua+RRhSs	.A+hGolLuGlFoIhsTh.aLIFE.palsphssp.-p.hshhpsspshlssallsaphsIslhLShlTIllSCFLLYSVasplYpGLllYslWIlhYEhhNhsl.lLTNs..cpshcEl+hh+WhGhlSRhhhHhFhl.FVlpaAahlYKspppssllua+RR.Sh............	0	1	2	2
+14901	PF15050	SCIMP		SCIMP protein	Bateman A	agb	Jackhmmer:Q6UWF3	Family	This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling [1].	27.00	27.00	29.60	28.50	26.90	26.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.74	0.71	-4.26	4	30	2012-06-26 16:34:01	2012-06-26 17:34:01	1	3	24	0	16	30	0	121.40	61	67.48	NEW	MsWWRsNFWlILAVAIIsVSsGLGLILYCVCRh.LRQG+KWElAKPLcpcpRDEEKMYENVhNpssVQLPPLPPRuh..PEcouPQEsPSQPsAsYS.VNKV+NKKsVuIPSYlEPEsDYDDVEIPAshEpp+	.....MsWWRsNFWIILAVA.IIlVSluLGLILYCVCRhpLRQGKKWEIAKPLKpcQtDEEKMYE...NVlNpSPVQLPPLPPRsh.S.Ecs...SPQEsPS.tP.PATYSLVNKl+NKKsVSlPSYlEPEsDYDDVEIPANhEpt............................	0	1	1	2
+14902	PF15051	FAM198		FAM198 protein	Eberhardt RY	re3	Jackhmmer:Q9UFP1	Family	This family of proteins is found in eukaryotes. The function of this family is unknown. Murine FAM198B is downregulated by FGFR signalling [1].	25.00	25.00	27.50	26.70	24.10	23.30	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.23	0.70	-5.74	8	108	2012-06-27 07:44:34	2012-06-27 08:44:34	1	3	42	0	61	111	0	277.00	52	64.22	NEW	usIRlYutpuPPWFSc-DIpsMRhLADupVsuhs+.........lPu+uts.hllLc.......pussssuptCssp.CGlIKRPhDhoEVFAFHLDRVLGLNRoLPAVuR+Fco.......hssGpspPVlLWDPSlp...ssss-psShpLsWspYQphLKp+ChtsGpl.....PpsphsCosIHHpEWu+LALFDFLLQIa-RLDRsCCGF+PcspDsCVppGLHt+CcNpcclpLsHIlpR+pDP+HLVFIDNpGhFc+sEDNLNFRLLEGIcEFPEoAVSVLpS.u+LRp+LLQSLFlDQhYWESQGGRpGl-+LIDVIE+RAKlLLpYIptHsl+llsMN	.....................................................................................................................utpsPsWhoccDlpth+LLAputVssht..........ls..u+utsh..lshp..............ts....s.s..hs.hCu.u.CGLlKpPhDhsEVhAFHLDRlLGLNRoLPuVuR+hc..............hpDGpspPlIh..Wss...slp...sss...spsp...sSltLsWhpYQpLL+p+Ch..sGps........sp.sCstIHHpEWu+hALFDFLLQlasRLDp.CCGFcP...c.pDsCVpptL+.KCcs.s.pltLsHIl.RppDPpHLVaIDNtGhhp+sEDpLNF+LLEGIcpFP-SAVpVLpS.tpLpphLLpSLhhDpVaWESQGGtpGlcpllcslEpRuplLlpaIptHshplh.................	0	8	13	29
+14903	PF15052	TMEM169		TMEM169 protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q96HH4	Family	This domain is thought to be structured transmembrane helices and includes the intermediary cytoplasmic domain. It is found in eukaryotes, and is approximately 130 amino acids in length.	27.00	27.00	98.30	97.90	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.81	0.71	-4.25	9	66	2012-06-27 09:45:27	2012-06-27 10:45:27	1	1	59	0	48	53	0	133.10	58	41.06	NEW	pt+psCphGlspG.HllLWSllClPlVFllSFlhSFYYGTlTWYNlFLhYNEERTFhHKIolCPhLIlhYPllIhssoluLGlYuAlsQlSWtaspWhpslpDhEKGFhGWlCuKLsL-DCSPYslVELhDs-s	....p..ppsCpsGscpGPHllLWoLlCLPlVFllSFlsSFYYGTlTWYNlFLVYNEERTFaHKIohCPhLILFYPlLIhshuhuLGLYuAVsQLSWuauuWWpuspDhEKGFhGWLCSKLGLEDCSPYolVELL-SDs...	0	9	14	28
+14904	PF15053	Njmu-R1		Mjmu-R1-like protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9HAS0	Family	This protein family is thought to have a role in spermatogenesis. This family of proteins is found in eukaryotes. In humans, it is found in chromosome 17 open reading frame 75 (C17orf75). Proteins in this family are typically between 217 and 399 amino acids in length.	27.00	27.00	50.10	33.60	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.26	0.70	-5.70	4	77	2012-06-27 09:53:00	2012-06-27 10:53:00	1	2	48	0	46	60	0	278.80	51	84.02	NEW	asLYuYRuuRhoQptuDo-DGpsuGsss-oPSG-DFSLSLVDTNLPuEsEsELRSFIAKRLSKGAVFEGhGNVASVELpIPtY+VGCYYCLFQQEK.LPEsAshESEpNssEYVVCFLGGSEKGL-..LFRLELDKYhQuLKsshssEp+sLEsclpsYLsSWFEssVCPIQRVVhLFQEKLAFLLHAALSYTPVEVKpuDE+Tc+DINRFLulASLQGLlpEGTMTSLChAMTEEQH+SlIlDCSGsQPQhHNAGSNRFCEDWMpAFlNGAEuGNPFLFRQlLENFKLKAIQDhNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHtEMPEA+sVVsVLEEFM+Eu	.......................................t.......t.t...stss........tth......t.ss.....stpDF.S...LoLhDosLPuEsEPELRoaIuKRLSK.GAlatGhGNVAoVELpIPt.t.VGCYhCLhpp..E+..sE.t.....ssh-u..p......t.....ss-YVlCF....LGGS..EKGLc.......hF+.L...ELDKYlQGL+ssh....s.sEp.p..sL-scl..+.sYLspW.aE-sVt.IpRVV.LhQcplsFL.LHAALSaT.VEVp..poD..-+TKpD....lpRFlpsASLQGL...p...ps...........T.h....s.SLCh..AhoE-p+psl..llDC.S..ss.Pphh..N.A.s..........S..N+FC-DWhpsa.Ls..us-tuNPFLhRQlLENFKL.KAIQDhNsLKRFIRQAEhsHYALF+CahFLpsCGsGDlLLp.hs+sEH..p..-hPEApsllsVLEEFhpE...............................	0	16	19	28
+14905	PF15054	DUF4535		Domain of unknown function (DUF4535)	Coggill P, Hetherington K	kh6	Jackhmmer:E0CX11	Family	This family includes the uncharacterised protein C7orf73 that is found in eukaryotes. Members are generally less than 100 residues in length. Although the precise function of the domain is still unknown, members have a predicted N-terminal signal peptide sequence which suggests they are short secreted peptides.	28.30	28.30	28.30	29.00	25.40	27.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.32	0.72	-4.55	29	115	2012-06-27 09:58:10	2012-06-27 10:58:10	1	2	61	0	77	131	0	45.20	40	60.68	NEW	+ushoFhhGsssGlYlAQNYpVPNl...pKLhpshh.hAKclE-pY+...KP	.........shhsFhsGsssGlYlAQNYpVPNl...pKLhpph..htKcl--ph+K...........	0	16	35	54
+14906	PF15055	DUF4536		Domain of unknown function (DUF4536)	Coggill P, Hetherington K	kh6	Jackhmmer:Q96GE9	Domain	This domain family is thought to be a transmembrane helix. It is found in eukaryotes, and is approximately 50 amino acids in length. In humans, it is located in the chromosomal position, C9orf123.	27.00	27.00	27.50	27.30	25.50	25.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.28	0.72	-3.89	11	53	2012-06-27 10:01:04	2012-06-27 11:01:04	1	1	48	0	35	58	0	46.50	40	47.33	NEW	-ChuCRllSGsGLIGuGsYVahpA++R.p.stphuhholsphssulG	.sChuCRllSGhGLlGuGuYVahtA++..h.K.shs.u.tolsphshulu...........	0	5	11	20
+14907	PF15056	NRN1		Neuritin protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NPD7	Domain	The domain family Neuritin1 (NRN1) is a GPI-anchored protein expressed in post-mitotic-differentiating neurons in the developing nervous system [1]. NRN1 is a glutamate and neurotrophin receptor target encoding a neuronal protein that functions extracellularly to modulate neurite outgrowth (OMIM:607409).\	\	  This family of proteins is found in eukaryotes. Proteins in this family are typically between and 158 amino acids in length.	27.00	27.00	29.80	29.20	25.40	22.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.22	0.72	-4.03	10	92	2012-06-27 10:04:05	2012-06-27 11:04:05	1	2	40	0	51	83	0	84.20	50	38.75	NEW	C-ulaKGFSDCLLpLGDsMuNYsQcl--cpslpoICoaWDDFHsCAsTALuDCQEsAu-lWEpLRpES+plsFQGSLFELCuuuouAssu	.......CDslaKGFu-CLlcLGDuMus.sp..t.......p.sppplcTlCp...W-DFHuCssoALssC..EtAsslWEpL+pES+phshpGsLa-LCuusst...ss...........	0	2	9	25
+14908	PF15057	DUF4537		Domain of unknown function (DUF4537)	Hetherington K	kh6	Jackhmmer:Q9NQ32	Domain	The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.	27.00	27.00	27.00	27.10	26.80	26.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.61	0.71	-4.34	24	111	2012-10-02 16:56:36	2012-06-27 11:18:52	1	15	44	0	74	124	2	127.80	31	19.59	NEW	sppVlARps...pDGaYYhGsVppph...ssstalV-a...........spptptltppclIths.ssh.ppsLpsGDtVLAh......hsstp.p..........YsPGhVh.............sspscplsVpFasGp.....psp..lPpppshhl.sp.shacpssthl	...............sppVlARp-...p-Ga.Y.a.G...plKpss....spsphLVcF.....................tttpppsVstppll.hu.suh..s.sLpsGDhVlAh......hpspthp..............YsPuhVlhh.ptp..........ssp-c.hTVhhhNs+........pth..lPtsslhhl.s...shathusph...................................	0	38	40	47
+14909	PF15058	Speriolin_N		Speriolin N terminus	Eberhardt RY	re3	Jackhmmer:Q76KD6	Family	This family represents the N-terminus of the sperm centrosome protein speriolin [1-2].	27.00	27.00	37.40	31.70	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.29	0.71	-4.41	7	60	2012-06-27 10:18:56	2012-06-27 11:18:56	1	4	26	0	35	66	0	166.50	43	42.05	NEW	Moh.ssaEGhpHphcRLV................pENp-LKK.VRLl+ENpcLKpA................LuEusts.stRtspsVhhP.uPAsApEss...psGhhshuPhAsh.soPp......Sst.tslhs.hTuoLssLLsu.ushSpps..ss.h............................os.h........ssuPGt.hAoSLulPppu.Lossu.........................shsuplAVShuSPLLoSTss..thsQphLtsP....................lushsLsEsPR	............G.pc.hpRLh................pENt-LKK.VRLl+ENp.L+ph................Lu-usttsss+.....t....slhhP..uPAhs..........Ess...tsGl.shu.hssh.sosp.................TusLpsLLsu.uP.hSpps.....................................................sssPu...hAoShtlP.pu.LoPsp.................hsspsssph.SPLLSs...........Ltss....................hsshsL.E.PR...................................................................................................................	0	3	3	7
+14910	PF15059	Speriolin_C		Speriolin C-terminus	Eberhardt RY	re3	Jackhmmer:Q76KD6	Family	This family represents the C-terminus of the sperm centrosome protein speriolin [1-2].	27.00	27.00	32.70	31.80	23.50	18.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.78	0.71	-4.18	4	66	2012-06-27 10:19:36	2012-06-27 11:19:36	1	4	32	0	39	68	0	137.60	60	35.82	NEW	lVGEIAFQLDRRILuhlFPt.hsRLYGFTVS.NIPEKIhQsSlps.saplDEchspsLTpRYVolhs+LppLGYNtcVHPshoE.LlNtYGILRpRP-LtAS.spS..sshLp+lLl-sV.PphLsDuLLLLSCLspLS+DDuKPhFhW	.........................lVGEIAFQLDRRILu.lFPt.hsRLYGFTVS.NIPEKIhQsSlps.DtplDEchhppLTQRYlolhsRLpp.LGYstcVHPu.hoE.LlNsYGIL+pRP..-LtAs.hto...sshLp+lll-sV.PphLsDuLLLLsCLspLu+-DuKPhFhW.................................	0	5	7	14
+14911	PF15060	PPDFL		Differentiation and proliferation regulator	Coggill P, Hetherington K	kh6	Jackhmmer:Q8WWR9	Family	Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells [1].	27.00	27.00	29.20	29.00	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.51	0.72	-4.06	7	87	2012-06-27 10:23:41	2012-06-27 11:23:41	1	2	40	0	40	71	0	95.70	50	94.60	NEW	MAAIPSSGSLVATHDYYRRRLGSTSSNSSCGSuEYsGEsIPHpPGLPKuDsGHWWASFFF.GKSThPhMusVlESsEpp.tohpsSsu.lsCsLApcsh......ppQ.uupsuKossu	....................MAAIPSuGSLlATp-YYRR.R.lGSoSS.sSS...CuS.sE.asGEsIPHp....PGLPKsDsG+WW.uSFFF.uKps.Phhssl.Epspp......tssts.h.s..h...s.........p............s........................	0	2	5	17
+14912	PF15061	DUF4538		Domain of unknown function (DUF4538)	Coggill P, Hetherington K	kh6	Jackhmmer:Q8N5G0	Family	This protein family is thought to be a transmembrane helix. Its function remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are typically between 58 and 87 amino acids in length.	27.00	27.00	33.60	33.60	25.60	24.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.80	0.72	-4.66	13	61	2012-06-27 10:24:17	2012-06-27 11:24:17	1	2	50	0	36	71	0	56.10	51	54.00	NEW	hhRGh+hslhlGGlVuhlGhAhYPIhlcPhhpsEEYK..clQplNRsGIcQE-lQPssh+	.................huRshRouLIFGGFlullGAAhYPIaFRPLh+hEEYK..+pQtlNRAGIhQE-lQPsGlK.........	0	9	12	22
+14913	PF15062	ARL6IP6		Haemopoietic lineage transmembrane helix	Coggill P, Hetherington K	kh6	Jackhmmer:Q8N6S5	Family	ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p [1].	27.00	27.00	27.70	29.50	22.30	26.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.01	0.72	-4.08	11	55	2012-06-27 10:28:35	2012-06-27 11:28:35	1	2	49	0	35	58	0	75.40	48	36.26	NEW	Qplps.VQuphshsh.WS.......+L.PLLsGLllsuFuYslVYLDSs.PGlhPPoPFSPps+pRhp..pupShHLuYhsAlhsG	...........................plpppstschshhsFWoh.......LllSLhuGh.CCSFSWTlTYaDSaEPGhaPPTPLSPu+hK+hs.....spSaHhGY.hAlLsG........	0	6	9	19
+14914	PF15063	TC1		Thyroid cancer protein 1	Hetherington K	kh6	Jackhmmer:Q9NR00	Family	Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma [1]. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle [2]. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor [3]. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.	27.00	27.00	28.80	56.20	23.20	17.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.71	0.72	-4.44	9	80	2012-06-27 10:42:52	2012-06-27 11:42:52	1	1	39	0	49	70	0	77.50	54	59.15	NEW	tot.hh.SsSlRVuPSspG.+FD..TAsRK+AsANIFcsVsp-sLQ+LFc+oGDpKAEERA+lIashspDsEEhA+ALhAL+	.............s.....h.ssSlhsuPSsh..hpt.s........stuRKpAsANIFpss-..plQpLFpp....SGDppAEERA+IIaphstDhc.hAcALhtL+............	0	2	5	18
+14915	PF15064	CATSPERG		Cation channel sperm-associated protein subunit gamma	Coggill P	pcc	Jackhmmer:Q6ZRH7	Family	This family represents the gamma subunit of the CATSPER, or cation channel sperm-associated protein complex. The complex appears only to be expressed in the flagellum of sperm. The complex is activated at alkaline intracellular pH, and being restricted to the flagellum is the mediating calcium channel.	27.00	27.00	73.00	28.20	25.30	24.80	hmmbuild  -o /dev/null HMM SEED	825	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.36	0.70	-6.81	4	89	2012-06-27 14:03:08	2012-06-27 15:03:08	1	3	30	0	42	80	0	504.50	38	85.95	NEW	Mhp.s....s...........shhlhhhVLLlsh+shutpshpcCoWhVslscap+lucphs.pp.....PlssV.p.hth..ssS.lpsoc.Y.uFPYaL+IphsCssKsSc-luRhhtLpGlpPhV+lhhp....ssssahphphE............................plph.h-sAsh+Ss.s....sC.s-hhCp.uWhsPhPhcsGoll.pV-lhssGlGsaI.ppR.hlphsGFhp.pstssssthultp-..l.t.thapshpuhPl....shuPVhILGGhsspchlLaosopFpcasllphpIsSphsuShhCshhuhssTIassluh.uoLhIppsphVh.asGsaosLh-+spuS....Rhh.scCI++Lpss..susGp..lLAlsst.pcGhlalGslpDu.hph..hsc.................taSsCphlsu.......uph.ssptTlLLLVths.hptotpaallpa..ssupcshElLYpIP-hIPpt+ph-aLhhLsocoass.......shhhscs.FhsslsshlalWGNhlL.p.............................................................................................................................ppss.h.loh.p.CPaphhph.plPp.Q+.oc.cpa.hhPshl..p.shHssNoLAlYpGLVaYhhah+s..-hs.h-shp.sshp.atp.ht....DpDYaFahhSNp...tslalsMsuYp+lashpushpl.Pp+hFLDpGspasaslhh.hasso.+sppp...thp..pplsLSlslu-PsslsVosppEhLlppsolLhpIsltDp+hsh-QshsGc+lptsSh.hpslsssGhphthTahhsHhp..t.h.hsVhIssPsGhRhth.lohoLpasht.spahhDpl.hstE.ssFhaRD.........D.shssSt.uhpGSash.VVsssshlpohpshh-pEI.Rhpushcp	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	9	10	15
+14916	PF15065	NCU-G1		Lysosomal transcription factor, NCU-G1	Coggill P	pcc	Jackhmmer:Q8WWB7	Family	NCU-G1 is a set of highly conserved nuclear proteins rich in proline with a molecular weight of approximately 44 kDa. Especially high levels are detected in human prostate, liver and kidney. NCU-G1 is a dual-function family capable of functioning as a transcription factor as well as a nuclear receptor co-activator by stimulating the transcriptional activity of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) [1].	27.00	27.00	30.60	28.30	23.90	23.20	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.10	0.70	-5.76	20	84	2012-06-27 14:54:08	2012-06-27 15:54:08	1	2	63	0	54	97	0	305.00	35	82.60	NEW	ssLlHlcA...sGsscTlHYlWss.hGsPolLlsh...Tsssso...lplsWschLssp.....hsuulphssps..pYotullhs+lhEFsDsNDouhhs..sssp.h.sYsLppFsWsphshs....sstslssshsut.hpp.......sGolshplsAFsspsRssphP+LLHouNSoQl-lslsslss+uspS...RFAlE............llsVssstsssssp...............p+SIDDEYTPuIFclsplhs.....hstsssssGalQW+PVuYspspRshssu..s.spps.......phpslps.....sshssoslshAaaGsp....h.hpuhNlSFGhssDG.FYpsosYhoWThllGhGpPPs-phSshVlhlhulGLGlPhlhllhGGlalsl++t+tpp	.....................sLlHlRA...sGsssTlHYlWss...hG..sPullllt.....Tssspo...lslsWsphlusp..................sssulhl.sps.l...paStAllFs+lhEasssssoshhs.........sp......hssYsLtpFsWsphs.s.....hs.tslssshp..Gpshpps.............sGSlshclpuFspssRssp..P+LLH.Tus.osQl-lsLsshss+....u..spS...hFuLE............lh.slupsssssphp...............pcSIDDEasPulFplspl.......................huo.ssGahQW+PVuasp.tp.tshpsu....hsspts.......shpss.s.........hshspsslhpAaaGsp.....................thpshNloFGsssss.hYhsppYloWohllGhG.PPsDthSsLVlslhuluLGsPhlhllhGGlhlhlt++p...p.................	0	19	23	36
+14917	PF15066	CAGE1		Cancer-associated gene protein 1 family	Coggill P	pcc	Jackhmmer:Q8TC20	Family	CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues [1].  CAGE-1 is predominantly expressed during post-meiotic stages. It localises to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa [2].	27.00	27.00	68.40	68.40	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	527	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.66	0.70	-6.06	4	63	2012-06-27 15:13:07	2012-06-27 16:13:07	1	3	26	0	23	63	0	325.00	48	63.21	NEW	hSEu-oMNhsuhSQDloaScSPhhMEToSTTSDLPQsEhKNscRENESc.TLsEDIYGTlDshLsDhsItN.ucNlLTQPVDT.SlSShRQFEPICKFHhhEAFNDE.hshpsLptuhsYTEKPEhQSpVYNsAKDsshKpDSFKEENsVET..SsSsscDQLupEhVRQ.ssRSPPLlHsSGET.KFsEsShsKSsuhEuALpPSQPQSFLhhENsppsscps..ptNsFp.LDLRA.YptEEhsVSSKtlQshG-IPEhsVsapKEVshEGV-SPtIsSPWSPAGIsWpGuAs.-suhMPDhEQShES.QPlEEDMAL.ElLtKLcHTN+KQpspIQDLQsSNhYLE++VcELQhpsTKQQVFVDIINKLKsplEELIEDKY+lhLEKsDTsKTLQNLpElLsHTQKHLQEu+N-KEoLQLplKKIKuNYV+LQERYMTEhQQKs+oVSQCLEM-+TLScKEEEVcRLQQLKGELEKAToSALDLLKREKcTpEQEFLSLQEEFQK+-KENLEERQKLKSRLEKLLAQVp	...................................................................................................................................................tpPt..s.hht..tcs..p.t...Eps.h....sh..pp-.hs.t.h.p..spS....h.p..tc.....h.E.sh.ts...tssht..ps.sh....................................hsspthp...-hschsss.tc..-st.-shpp..thhSshssssl.hpsts..-ss.h.DhE.shEuLpPl.p.ED.hALNEsLp+LppsN+cQphpIQ-LptpNhhLEp+lcELQhphs+QpVhlDlIsKLKtplEcLI--KYplhLEKN-hp+pLpslpEh.spop+pLpES+p-KchLpLphKKhKspYhpLQERYhsEhppKscs.ophlEhp+sLSpK-EElpRLQph+t-hE...+sT.SALshLpcEKc.pEpEhLuhp.EFQ+h-+tpLpERpcLK.plpcLlsQl.........	0	2	3	5
+14918	PF15067	FAM124		FAM124 family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9H5Z6	Family	The exact function of this protein family remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are approximately 480 amino acids in length. There is a conserved LFL sequence motif.	23.50	23.50	23.60	41.90	21.60	23.00	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.51	0.70	-4.93	13	111	2012-06-27 15:31:04	2012-06-27 16:31:04	1	4	44	0	66	93	0	222.70	50	52.79	NEW	lolHlls-sG-uphLQpAlDpLLsaIcPDlpLFpVS.ERtssh+tpcstptp..........tsphPuLuVlLFLpEs.hG..EEplhplpctLppPPW..paHHTppspG+..h............PahsssQDFaoLusthPlWAlRpVHYGpEIlRhTlYCsa-NYsDhl+hYElIL++csst+KsDFChFslYos.sh-lQlSLKpL.PhGhsPpPp-SulLpFRV+-lGQLVPLLPsPCoPIScsRWQTpDaDGNKILLQ	.....................holHllAssGcuphLQpslDplLshIpP-lpLFpVS.ERtush+hpct.ps..............st.PuluVlLFLp..Ep.hG..EE.....plhplpcsLQ+PPW..paHHTppspG.R..hh..................PYhsssQ-FaoLss..thPlWulR.VHaGpEIlRhTlYCpa-NYtDslRhYEhILpRps...otpKssFChFslaSsh..shslQhSLKpL.Phu.sssPp-SSVLpF+Vc-IGpLVPLLPNPC..sPISpsR.WQTpDaDGNKILLQ............	0	12	16	34
+14919	PF15068	FAM101		FAM101 family	Hetherington K	kh6	Jackhmmer:Q8N5W9	Family	This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilise peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes [1].	27.00	27.00	32.50	29.40	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.45	0.70	-4.88	12	102	2012-06-27 15:39:28	2012-06-27 16:39:28	1	2	41	0	55	78	0	169.70	52	92.01	NEW	MVG+LpLQsh..s-sLctpsR.-GlLDSPDSGLPspPSPS..aasLusGhh........ssh......p.ptspput..s.PhhL.ss.uspspPRhpPl.FGEuIElcPhPs+EIRhsSpVKYDSE+HFhDcVhhhPls.slouhSpTllulPNCTWRsYKoplphEPRp+shRFpSTTIlaPKHs+ohYpTTLsYss...tpstRhFhSSVpLEssE	.....................................................................................ss...........................................s.....h..ss...ssthpPRh..hPl.FGEulEhsP..PspEl.R..hsSpVKYDSE+.HFhDcV.hhPls.sVsuhSpTllssPNC...TWRsY+uplphEPRp+shRFpSTTIlaPK+s+ssYpTTLsYss...t+s.hRhFhSSVpLEhsp...........................	0	4	7	22
+14920	PF15069	FAM163		FAM163 family	Coggill P, Hetherington K	kh6	Jackhmmer:Q96GL9	Family	This protein family is alternatively named Neuroblastoma-derived secretory proteins. Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow [1].	27.10	27.10	27.20	27.10	26.90	27.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.33	0.71	-3.61	13	90	2012-06-27 15:45:19	2012-06-27 16:45:19	1	2	40	0	58	70	0	148.20	51	97.46	NEW	MTAGTVVI....................TGGILATVILLCIIAVLCYCRLQYa...CC++p.......-s-p-.....ccp.shshpsh.s...................su.shhs....s.sppptpsp.hCsoC..o.at.s.Falpss............GGcRlsatshp.......................h...h.thhp.spuIST-V	............MTAGTVVI....................TGGILATVILLCIIAVLCYCR...LQYY........CCKKs.......coE--......EEE.Dhs...scs+hPshpusps.sh........sstsuLhPhtspshuppsstupshCsoC..S.YpsP.Falpps-............stNGGERlsatshp.c-ht.Ps...................hthus.Quhsssh.uuhREuFopsRuISTDV.......................................	0	5	10	22
+14921	PF15070	GOLGA2L5		Putative golgin subfamily A member 2-like protein 5	Hetherington K	kh6	Jackhmmer:A8MS94	Family	The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.	27.00	27.00	27.20	27.20	26.20	26.70	hmmbuild  -o /dev/null HMM SEED	617	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.33	0.70	-13.17	0.70	-6.03	8	690	2012-06-27 15:46:46	2012-06-27 16:46:46	1	6	83	0	210	470	0	199.30	19	59.74	NEW	QLpESl+QLQsERDQYAEsLKEEuAlWQQRhQQMSEQl+pL+EEKE+uhuQVQELEoslAEL+NQhsVPP...sPpPPA...GPSEsE.ppLQuEsEQLQKELEsLutQlQAQV+DNEsLSRLNQEQEpRLLELERsAEpWuEQAE-R+QILESMQSDRsTISRALSQNRELKEQLAELQNGFVKLTNENMElTSALQSEQHVKKELAKKLGQLQEpLGELKETVELKSQEAQuLQpQRDQYLuHLQQYsAAY.......QQLuuEKEhLHKQhLLQTQLMDRLQHEEVQGKsuAEhApQELQEoQERLEAssQcNQQLQAQLSLhAsPG........EGDGLDSE-c-E.........EsspPpluIPE-LESREAMVAFFNSAlApAEEEpARLRpQLKEQKhRCpcLuHLlAssppp.ccc.AsuP..........tsuGD.SVPsEoHpALQVAMEKLQuRFTELMQEKsDLKERVEELEHRCIQLSGETDTIGEYIALYQsQRAVLKpRH+EKEEYISRLAQDKEEMKlKLLELQ-LVLRLVsERNEWpuKaLAAAQNPus.sosussA......QELGAA-sQGsLcEVSLAp.ss.........ltPsQGEA..Gsss......PpENPTAQQIMQLL+EIQNPQERPG..LGpNPCIPFFYRADENDEVKIMVl	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	122	129	171
+14922	PF15071	TMEM220		Transmembrane family 220, helix	Coggill P, Hetherington K	kh6	Jackhmmer:Q6QAJ8	Family	Transmembrane 220 (TMEM220) is a domain of unknown function. It is thought to be a transmembrane helix. The length of this protein is typically between 150 and 160 amino acids. In humans, it is found in the chromosomal position 17p13.1.	27.00	27.00	29.30	28.40	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.53	0.72	-3.58	29	81	2012-06-27 16:25:50	2012-06-27 17:25:50	1	1	72	0	51	95	19	97.70	30	68.70	NEW	hFshsAhlQlNDP...........DshlWlslY.....hlsull...shhhhhthhsphlhhhhss............shhhhhhhhtsslhttht.t.th............phE.uREhhGLhlsshhhhlhhhhs	.........hFshhAhlQhNDP...........Ds.lWhslY.....hlsAll....hl..hhs.tlssp.hlathlushah........hhshhhshhlsshlhtcsppshh.......................ppEcuREhhGLlIlsshhhlpt...p...........	0	17	29	34
+14923	PF15072	DUF4539		Domain of unknown function (DUF4539)	Coggill P	pcc	Jackhmmer:Q8N3J3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 230 and 625 amino acids in length.	27.00	27.00	27.70	42.00	26.70	26.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.70	0.72	-4.29	32	116	2012-06-27 16:39:42	2012-06-27 17:39:42	1	2	98	0	75	119	2	86.40	37	17.40	NEW	stKVsplssll+slst..........sst.Ds.hlhlpD..PTGphpuslH.+clh.p..p..asstlssGusLlL+cVs.Vas...........ss......tptta.LslThpNllplass-s	..p.sKVsphsshl+Slst..........ssh.Ds.tllhKD..PT.G.phpuolH.+pllp..p...htspLpsGuVLlL+pVu.VFs..................PS......hpspYLNlT.pNLlplass-.s.........	0	27	38	56
+14924	PF15073	DUF4540		Domain of unknown function (DUF4540)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A4D263	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 302 amino acids in length. In humans, it is found in the chromosomal position, C7orf72.	27.00	27.00	28.30	28.10	21.20	17.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.81	0.71	-3.60	6	31	2012-06-28 09:34:24	2012-06-28 10:34:24	1	3	28	0	21	43	0	119.80	47	33.03	NEW	PsKPlsFVSsSoRSKYIPLYTG+VQSTsADDlDNPhGDIsSlApPRsSchhYTNoSRoAsIPGYTGKsHasAT+PsNschPSpoPSsD.SEhHRlhh+cMtV.....DhFtHQuPLS+MVTTVpPYNPFNKKDKET	.............................s+PlsFVSsSoRSpaIPhY..oG+V.pSssu.DDlDNPhGDhtulupsRpS+.h....Y.Tsoo+usNIPGYTGKV..HFsATHPAN.SsIPsT.sPSsD....SEh+RslhcEMtV.......DhFRHQuPLS+hVTTV+PYNPFNKK-KET.............	0	11	11	11
+14925	PF15074	DUF4541		Domain of unknown function (DUF4541)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A4QMS7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 100 and 163 amino acids in length. There is a conserved KLHRDDR sequence motif. There is a single completely conserved residue Y that may be functionally important. In humans, the gene is found in the chromosomal location, C5orf49.	25.00	25.00	26.40	25.10	24.30	22.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.01	0.72	-3.44	12	46	2012-06-28 09:38:35	2012-06-28 10:38:35	1	1	39	0	33	52	0	87.70	51	61.98	NEW	YFssspppsphoh....YDplFph.ppsa...ssKLHRDDRp+hpslGLclppEEpp+sVPlLsSS.YG+.h..cpPl-..s+.casRls+Vps-FYp+ssI	.......Ya.p.tpsGllSL....YDslF++.c.sY...sQKLHRDDREHAKolGL+VNEEEppRsVsVLoSSVYG+Rl..ppPlEPhsR.casRssHVpsDFYRKNsI........	0	16	19	22
+14926	PF15075	DUF4542		Domain of unknown function (DUF4542)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A8MV24	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 123 and 173 amino acids in length. There is a conserved IPPYN sequence motif. The gene that encodes this protein in humans, is found in the chromosomal position, C17orf98.	27.00	27.00	28.20	33.80	26.60	23.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.63	0.71	-4.22	9	48	2012-06-28 09:40:34	2012-06-28 10:40:34	1	2	36	0	36	51	0	121.10	49	77.44	NEW	LE+uFVLDuluVuolupshp+tpPKhhoAIPPYNAQpD+HApsYFcS.sVpslL++TtQ....spsGsohsGhllD+ahhhG........tGttYlspRNhsGAG..........HSpptVsGHs.ahsshpshp.GapGhFGaRRNTPpLRppPSsF	..hEKuFlLDuVAVuohucs.as+tpPKlhSAIPPYNAQpDhHAcsYF......pS+sV.slLRKTsQ....c+GGTutcGhllDhhalhG........tGpcYLs+RNhA....GuG..........HShppVsGHs.a.usl+sh..GaNGpFGYRRNTPsLRppsSsF.................	0	16	18	22
+14927	PF15076	DUF4543		Domain of unknown function (DUF4543)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0P5P2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 90 amino acids in length. The human member of this family is C17orf67.	27.00	27.00	75.00	75.00	22.30	19.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.80	0.72	-3.95	4	35	2012-06-28 09:57:32	2012-06-28 10:57:32	1	1	31	0	22	30	0	72.90	78	80.11	NEW	aT.DASPILsEKpAKQlLRo+RpDR.pKsGaPDEPMREaMLaLQtLEQRuEEQFLEHWLNPHChPHCsRNlVHPV	.ht...-uSPI.LpEKQAKQLLRSRRQDRP.SKPGFPDEPMREYMHHLLsLEHRAEEQFLEHWLNPHCKPHCDRNhVHPV..	0	1	2	8
+14928	PF15077	DUF4544		Domain of unknown function (DUF4544)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q3KP22	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 118 and 256 amino acids in length. The human member of this family is C11orf85.	27.00	27.00	28.60	28.50	22.20	17.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.24	0.70	-4.85	6	50	2012-06-28 10:05:16	2012-06-28 11:05:16	1	2	29	0	21	34	0	161.40	51	91.32	NEW	MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRsVLGNLDsLQPFATEHFIVFPYKSKWERVSHLKFKHGEsVLVPYPFVFTLYVEMKhFHEsLSsGKPhsDSPLGLVLAERKAAtAsM+..KRKpsEVPSSPSRPGLDRs.........uKc........KP.p+cs+R.hphhsshstscVtsQ..h.csu.tGphlP.pppos.h.L+sPpphtssu.hGF	...MSLKPFTYPFPETRFLHAGssVYKFKIRY...GpuIRGEElEsKEVIhpELEDSlRsV.LtNhDsLQPFs..T-HFllFPYKu+Wppsu+L+FKHtphhLhPYPFVhTLYlEhKhFp.EsLssG+..hps.s.ths.scp.....cs.ts.h.hc...KR+hh-....sostpst.....pR...........tpc........p..pcps.pp.h.......hsh.shscl.pt.....tps..G.h....pps.........c.....t..u.hG..............................................	0	3	3	5
+14929	PF15078	DUF4545		Domain of unknown function (DUF4545)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JVX7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 417 amino acids in length. The human member of this family is C1orf141.	27.00	27.00	30.80	30.70	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.61	0.70	-5.57	4	51	2012-06-28 10:14:33	2012-06-28 11:14:33	1	2	20	0	18	46	0	233.80	39	100.21	NEW	MsE+IL-KhDhL-EpA+hLhAhRtKpsshppplKKKs.lhPLhFDaplcFt-sIssShSKT.upIpKD+upslKKsKR.VSFK.pPcPp+SDFEcSsLRPPhLsTsIphpE.K.hE.tEE.LKSRSh.Sh+YLKDpsETE.AKPh...h.....................................sQHcpps++ohcSTsaSusSSppsptp+.Ess.h.TKEsEhhRNDQhpch.sV+Qp.LLPLshED.LKsPchKhIDluPscTVpopMcpNcsNPIIFa-TcYVQMLhLTK.RhsPauhc......ap+pNlVLE+NCEhLKolhpDps.TsSKsppThsssQpKcl.slShElup+sls-Kh+KKpc+.s.cpIS.spLYNlSQTFSSLoKKFVGahDKsVIQEKSsKss+FE+.FSpsKPss..KFos.PlKYsSKP.+NILclHKlNNlTPLDsLLs	.....................................sphQsph+Kps.hhPLTFDFplpFEcs.s.s.htKt.spIpcs+.sh..shp.psch.ssh+.....p.......s.pspFpp.slt...h.s.hp..pE..c.............................................................................................................h............pEsp......hp....htpp.hhPLshED.LhpsphKhl..t...p...ph..........................................................................................................................................................................................................................................................................................	0	2	2	2
+14930	PF15079	DUF4546		Domain of unknown function (DUF4546)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5T0J7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 88 and 212 amino acids in length. The human member of this family is C1orf49.	27.00	27.00	76.30	35.60	21.70	26.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.23	0.71	-5.17	5	48	2012-06-28 10:17:19	2012-06-28 11:17:19	1	2	20	0	16	49	0	178.30	66	92.20	NEW	MSAKRAE.KKTsL.......SKNYKAVCLELKPEPTKTYDYKGsKQEGhFTKsGsT+ELKNELREVREELKEKMEEIKQIKDlMDKDFDKLaEFVEIMKEMQKDMDEKMDVLINIQKNsKLPLRRuPKEQQELRLlGKTD+-PQLRl+KMD...GuDGsPLALHKKlVAPQpT.+sPLDPLHpCsoCCEKCLLCALKNNpNRG+.saHAWusFSPL	..................MSAKRAELKKTpL........SKNYKAVCLELKPEPTK...TaDYKuVKQEG.FTKsGsTp-LKNELREVREELKEKMEEIKQ..IKDlMDKDFDKL+EFVEIMKEMQKDMDEKMDlLINhQKN.KLPLRRuPKEQ.QELRLhGKTcp-PQLR.KKMD...GssGAPhuLHKKsMAsQKs.pssLDsLHpCtoCC.EKCLLCALKNNhNpGt...................................	0	1	1	1
+14931	PF15080	DUF4547		Domain of unknown function (DUF4547)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q147U7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 144 and 206 amino acids in length. The human member of this family is C3orf43.	27.00	27.00	101.90	101.70	20.10	17.50	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.38	0.71	-4.89	3	28	2012-06-28 10:20:18	2012-06-28 11:20:18	1	1	22	0	16	37	0	189.00	76	93.09	NEW	DHKLQALETQFKELDFIKDNLTQKFEHHSKTLASQAAQDElWTAVLALpFTSMELNILYSYVIEVLICLHTRVLEKLPDLVRSLPTLASVLRRKVKNKRIRsVWESILEEaGLQEGDITALCTFFVAHGNKAEHYTAKVRQMYIRDVoFMITNMVKNQALQDGLLRAVQVIEKGKAsRTPEcpKSPLKELIPSVKu	.D+KLQALEsQFKELDFTKDNLhQKFEpHSKoLASQAAQDEhWTAVhALcFTSMELNILYSYVIEVLICLHTRVLEKLPDLVRGLPTLASVLRRKVKNKRIRVVWESVLEEpGLQEGDlTALCTFFIAHGNKAEHYsAKVRQMYIRDVTFhITNMVKNQALQDuLLRAVQVIEKGKAVRsPEcQKSSLKELIPSVKN.......	0	1	1	3
+14932	PF15081	DUF4548		Domain of unknown function (DUF4548)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95561	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 178 amino acids in length. The human member of this family is C1orf105.	27.00	27.00	65.70	65.70	22.80	21.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.06	0.71	-4.71	4	26	2012-06-28 10:27:17	2012-06-28 11:27:17	1	1	16	0	9	25	0	132.00	63	89.87	NEW	PWLSEASLVNKPLlLSlP+RYP+tSushLsSsKKsMsLPlLhQsP.DshSKARRNQs-sMLlRNpQLCSTC...QEhKMVQPRTMpIPDc.KsSFENsMSaR.MSLHpPKhQssscs.+sDIPTESI+YRLPILGPRTAVFHGLLT-AYcTL+EpQ+SSLPRKEPhGKTsR	...PWhsEAShlNKPLlLSlP+RYP.tSushLsSs++shshPhhhQsP.DshSKARRNQpssML.hRNpQLCSTC...pEhKMVQPRshpIPD.D.KsSFENhMSaR.MSLHpPKhQssscsa+cDIPTESIH.YRLPILGPRTAVFHGLLo-uYKTLpEpQpSSLPRKEPhuKThR..........	0	1	1	2
+14933	PF15082	DUF4549		Domain of unknown function (DUF4549)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5T699	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.	27.00	27.00	35.90	40.40	21.30	18.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.81	0.71	-4.55	4	24	2012-06-28 10:34:07	2012-06-28 11:34:07	1	2	20	0	19	27	0	128.00	53	23.05	NEW	DplYKlSSTERV..LEKELtspLsELKsplE-pGlL.GTsNRsaSSlthPKDssaFR+EREhhLKKsLQVAEuKPLVIQADlhpRELESCLpREYTstsLPLLLhQaYT-RItQLuQSKYLHhLRWKRFCp+SphhEpLYPLYp	.......................DplY+lsSoERlp.LE+cLthpLsELKsEIEEpthh.sst..p+s..aSSVphPKDltaFR+EREhALK+sLQVAEuKPLVlQADVMQRELESCL+REYTsENLPLLLhQaYs-RIpQLsQsKYLHMLRWKRFCpHSphhEQLYPlYp.........	0	8	10	12
+14934	PF15083	Colipase-like		Colipase-like	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NCL2	Family	This is a family of colipase-like proteins.	27.00	27.00	31.50	28.80	25.70	25.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.80	0.72	-4.05	9	62	2012-06-28 10:57:55	2012-06-28 11:57:55	1	3	22	0	35	60	0	71.90	41	90.69	NEW	polh.pClsapKsNuhpCs+HSECpSsCClpspppsttFC.sP+o.IhhpClPhRKsstsh...CpptpEChSpsCl..pE....+Cs+RstlL	...................hpK..s.hCpcHsECpSsCClhss.ssppFC.ss+o.IhhpClPW+Ksshth...Cp.t.pC.p.p.h..............................	0	3	3	7
+14935	PF15084	DUF4550		Domain of unknown function (DUF4550)	Bateman A	agb	Jackhmmer:Q9ULG3	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 100 amino acids in length. This domain contains an N-terminal HXE motif.	27.00	27.00	52.70	51.30	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.13	0.72	-3.89	8	33	2012-06-28 11:36:29	2012-06-28 12:36:29	1	3	30	0	20	49	0	98.00	47	16.75	NEW	spsaaHIEY.hhPcD.cspKlDlVlassVAKl.......Fh-sph.Kssp.h+.ssDpsW.lsWspsaslsVsp-hlpchh.+tlsl+laDo+-KVSs+ARaDRsKsht	.....h.ppaaHIEYaLLPDDt.EP+KVDlVlF.shl.AKV.......FL-Sus.KTV+PWc.EGD+sW.VSWpQTFsIsVTKELL+Kls....h....HKITL+lWDoKDKlScKsRY.R.Ksh.s....	0	9	10	11
+14936	PF15085	NPFF		Neuropeptide FF	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O15130	Family	\N	27.00	27.00	34.50	32.50	23.70	22.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.78	0.72	-3.76	9	43	2012-06-28 11:36:44	2012-06-28 12:36:44	1	1	29	0	15	40	0	90.30	49	79.89	NEW	stuhpp.ppshsc-D.tP.ssp-thscphhphsup.......................lLRuLL.u.QR.sRs..SsLaQPQRFGRsopGsh.sEpph.psRsWEussuQhWShAsPQRFG.KK	...........................................................................................-sph.so..........LLRsLLQAMpRPGRS..uFLFQPQRFGRN.opGSWusEcL...SPRAhEul..........supFWSLAAPQRFGKK.	0	1	2	5
+14937	PF15086	UPF0542		Uncharacterised protein family UPF0542	Bateman A	agb	Jackhmmer:Q7Z3B0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved LSWKL sequence motif. This family includes human protein C5orf43.	27.00	27.00	47.90	47.80	24.20	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.57	0.72	-4.26	3	46	2012-06-28 11:42:20	2012-06-28 12:42:20	1	2	45	0	33	41	0	73.30	71	82.43	NEW	M..FDl.KAWL-pV....VcWAA-DPGuFlTTVLLuLTPFFLlSAVLSWKLAKtIEAE-KRcKp+pK+ptNlAcsRRpKKD	.............MhDl.KAWAEYV....VEWAAKDPYGFLTTVILALTPLFLASAVLSWKLAKMIEAREKEQKKKQKRQENIAKAKRhKKD........	0	8	9	18
+14938	PF15087	DUF4551		Protein of unknown function (DUF4551)	Bateman A	agb	Jackhmmer:Q8IXR9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa. This family includes human protein C12orf56.	27.00	27.00	36.80	62.90	17.10	23.60	hmmbuild  -o /dev/null HMM SEED	617	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.20	0.70	-12.95	0.70	-6.15	7	68	2012-06-28 11:45:46	2012-06-28 12:45:46	1	2	35	0	29	57	0	424.10	47	94.34	NEW	MA.....tsuhsstpNu+LDuFL+RshssplY-plRuaEPClVVS-p.c+sFhaVlLSD-plYLTEpPPRslphsVsh+cIhuI-LIsDhP-FLSGpDREpsQHIRIhY..................ussp.shPtptthutsppssc.sst.h.h.sphS.ohspu..sLtuspcposthtsspst.stsL.c.p.tt........................hPp.s..sspss.spcpstshPsssssshtsps.ssstss.spts.p.ptssptht.hsSllup.lppspshc............cc-uELHLYhlSsTSplaL+LpSoWNsYIIRuT..Lh.DPlYhpcpss....pusp.........p.EcphplFsQLpuELL.csssLEplahLLQEL+sAApRNhsLK+LFWKosDLF.FLVppLp-..L.tscstpshpt..ppADcLhlsh.lsQTLuhMFRET-l-ssRLshLsAcpGshh.pLLlhLlscPph.h.....p.p..tp...............cs-lQtLht-YhDsAsuLLFEllLlsQpushsssss...............phhsluWlhphLpspP..lhsFluh.scpsVhsLSsot.t.LSPuQAlLLYQphhlLhuCLQaSppLupaIRssa+EEFRYFl+hPslEcKLPspYPIopPsh+LlpplLphl.	.......................................................................................................lsDhPpFLps.ppphsQHIplha...................................st..p....h.hth..t..ppphp.....p..s......h...p....p.tts...h.......................................................................................................................................................................t.................................................................................hchY.lp.tS.h...hps.Wpsh...h...................................ppEcphphFsQL+uELh....cs.olc+lh.Ll.EL+sAAp+shhL++LFWKosDLFhFLVspLcE.hLstsp.stpuhpstsp..csDcLh...hsh.llQTLshMFRETEhEsuRLNhLsA++usLh.pLLllLlscPpl.p..tss..sh.p.sss..........st.....hsh-scLQpLlhEYhssAouLLaElLLlhpQushs.s..us...............pF.uluWhhphLQspP..lhsFlut.VcplV.p................sLSss..p.LoPsQAVLLYQphhlLhuCLpaSppLupalRssa+EEF..RYFl+hsslpc+LP.pYPIopPThpLhcElLpll............................	0	9	10	15
+14939	PF15088	NADH_dh_m_C1		NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O43677	Family	\N	27.00	27.00	39.60	39.40	22.20	21.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.49	0.72	-4.46	7	40	2012-06-28 11:47:20	2012-06-28 12:47:20	1	1	32	0	17	39	0	47.10	70	65.75	NEW	hFhspcPspupPNWL+VGLsLGTolFlWhhLhKQHN-DVhEYK+RNGLE	.......KFYVREPssuKPsWLKVGLTLGToVFLWlYLIKQHNEDVLEYKRRNGLE..	0	1	1	2
+14940	PF15089	DUF4552		Domain of unknown function (DUF4552)	Bateman A	agb	Jackhmmer:Q86WS4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. Proteins in this family are typically between 425 and 649 amino acids in length.	27.00	27.00	150.10	149.90	22.70	21.80	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.66	0.70	-5.58	5	29	2012-06-28 11:47:55	2012-06-28 12:47:55	1	1	23	0	14	25	0	374.50	62	67.71	NEW	SsGN+sFLT+os.uVVMGEDCGShDERRQSDFITEKpSlQHIWGENRKEhSNFLEDVNQsTssLLSENCDSFIScNMINLLNIDQQ+IKKTFDKCDYDoMuDsssVlSSDKNHsTDRCIRSIFTDPELsFSNSTFNKoSYPEKCQPNK.CQKEYsNNERNsLSTSFEKDaYPASS-+KGKFENDYQEKTPQ+co..QKYPVNHMuNIPLEELHSKQSWDFGlGE....ILMcEGGhsSLKu+sTSTKKs.YLDSSQSSQSTSYSPRPTD.SCFSSSSEMPSEDEDQI.QQIEDSNRpSIKsKETTNNFYLEsM...sKLPsD+IIKNNAKhHKQNENFHQFShKNNTDQFPQSQCNSAHILQNKTosNCILQlARCDAWVQTESEsVMEEKLDlAIQCDIISKCKCRS.......-VSsLCNVERCoENlKADTTGGQEILKNN	...S.GNRNhLTcpP.sVlMsEDCtSMsEhRQSDaITEKpSlQHIWGcNtKElSNFLEDVNQssPslLSENCDSFVSQNMINlLNIDQQ+IKKTFsKCsYDSMGDhCsVTuSDKNcsTDRCIRsIFTVPELT.FSNSThNKTSYPEKCQPNKphQ+EYNsNERNDLSTSFEpDhYPuSSE+K.GKhENDYQEKsPQKsI..QKYPsNoMssIP.EELHtKQSWDFGlsE....ILMcEGGhsSLKup.PTSscKI...LDSuQSSpSoSYSPRPTD.SCFSSSS-h.SEDEDQl....QphE-SN+hsI+scEptN.....NhalEpM...sclss-cIlKsNsKhHKQNENFaQaShKsNoDpFspSQCNSAHlLQNKTssNClLQsuRCDAhVQTEoEslhcEKLDAAIQCDlIScCpC+s.......-lS.LsshcpCotNlpuDTTGGQEIhpNN..........	0	1	1	2
+14941	PF15090	DUF4553		Domain of unknown function (DUF4553)	Bateman A	agb	Jackhmmer:Q8N655	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. This family includes the human protein C10orf12.	27.00	27.00	45.20	45.10	24.00	22.70	hmmbuild  -o /dev/null HMM SEED	463	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.77	0.70	-5.49	7	61	2012-06-28 11:50:07	2012-06-28 12:50:07	1	1	32	0	32	58	0	389.50	41	45.00	NEW	shDslhsspPthhhWssptpNppLltEhNspa.plppuWlQ..lpt-ptssshs+s+scphp-.haKspp.hcpChhtLEV...SPVpMLF.KpapLsclCpWFhpTTETpSLslV+KhNsR.Ph-l.ss+t.h.phpsSs.....hpsphh+KHhKKFAhuoPu+sshKhphLathlppss.pscup.....oLu..tcsphcclpp-Rhup.tppl.o.uoschhpKhpNlRhhhpsQh.......hpss.G.tsusEsppsppols.pslhsP....shpstspphsspschss+sph..........pto.psppshpKtps.schpssphpupo.+cs+lhh+Khsplcp.ps.phsshhhpPtuh-psu..s+ps..cEs+hh..+ppss+pss.p+ppcEppsh+sspPs..ottlst..cpptLscusspspps..sscthuphppRtRP.hKosE.sstpR+++.psptsp.tuhhs+hpst	.....................................slDslhsppPphh.WsspppNppLltphNspa.plppuWlQ..lp+-ttsssht+s+s.cp.p-..haKspc..cpChspLEs...SPVpMLF.......ppacLsplCpWFhpTTETpSLsIVKKhNsR.Ph-l.ss+tsh.thpsSs......hpAphl+KHhKKFshuoPu+sshKhp.hLath.hpps..p.lcsp..........s.u..pcsphcclp....c-R.p+.s.t.l.s.uoschhpKhpNlRhhhpsQ........hpps.u...u.spsp.uppoVs.pslhsP....shpss...spthsshsc.ppthph..........ptspp.hpc.h.Ksph..p.chptsphpot...s.....pcs+h.hhKhsp.cphss...phsshhhpPtuhDpsu..s+phphcEsKhhh..+ppsu+pss.p+pp+E.pst+ssps...s-thst.hpppth.scssshspps..tsch.uphpp.....+tRP.hK...osE.ss.pR+++.psp.sp.tshhp+.......................................................................................................................	0	2	5	16
+14942	PF15091	DUF4554		Domain of unknown function (DUF4554)	Bateman A	agb	Jackhmmer:Q8N6T0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.	27.00	27.00	52.30	43.80	18.70	23.80	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.37	0.70	-5.75	4	51	2012-06-28 11:52:02	2012-06-28 12:52:02	1	2	24	0	17	40	0	291.10	58	83.54	NEW	MTDsLVIK+FL+KIlhVHsKl+FpFSVKVNGlLSt-IFus....ENEPsLsLuNGISLhlshpHYVS+PpFshsE.pCSRIHPVLGHPl.LhIPsDhAsMGLLGELhLTPAAALCPsPKsaSNQLNRISS.lp...IFLYGPhGLPLlhss.EQPpTohF+DhuhhlDWKKapLsMlPNLDLsLDpshlLPDVsYpVE............ssEcsQSQs.cuQtQTLLLFLFVDFpSsFPVQQsElWulaTLLTsHLssILsES+SsVQsSIQssVDpsLEpHaQtAKs+Q+LQASLSVAVsSIMSIlTGSTsSSFRKhCLQoLpAsDTQEFpTKL++sFp-ITpHpFLs+CSC-hcQclT.ccp.oAQsTcDthcs.suLEhhh-ouGQsENKRLK...cuS.phutccopThPsuc-usssEsssppssPTstutpsp.upuphtssGsththsupssth.-sLWLQEVSNLSEWL	................MTDCLVIKpFL+KllhVHPKlRFpFSVKVNGlLSpElFGs....EpEPsLsLsNGIuLlss.pHYh.psthsshE.hCSRIHPVLGHPVhLhIP-DhsshsLLGELhLTPAAALCPs.Kl.uNQL.s+ISo.lt...IFLYGP.GLPLh.sp.tp..hshhps.s.hlsWKKapLphlPsh-.pLpps..hhPDhsYplE............s.p.ts..psps.t..tpsLLLFlFhDFpssF.sQ.hEhhts.sLLpsHLssILhcs+shVQsslphslDpsLpQHpQtsKs.Q+.............................pshps.pspEhthpLtp....hh....h..h..t.t.......................................................................................................................................................	0	1	2	3
+14943	PF15092	UPF0728		Uncharacterised protein family UPF0728	Bateman A	agb	Jackhmmer:Q8N6V4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa. There is a conserved GPY sequence motif.	27.00	27.00	76.20	32.00	19.90	18.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.92	0.72	-4.11	10	35	2012-06-28 11:54:29	2012-06-28 12:54:29	1	2	30	0	25	42	0	85.10	57	77.93	NEW	MPppuhVslRYGPYsusGl.V-HRTtRL-GLQAVLtpDGHpVlLEch-DaNsVELlVNGEhVFpCsIp-L-......FGGDG+LDP.......LCcEAhpAV	.......MPcpAlVhlRYGPYSAs.GLsVEH+TaRLpGLQAVLspDGHcVILEKIEDWNlVELhVNtElVF+CNIpDLE......F.GGDG+LDP.......LCccAhhAV................	0	7	10	13
+14944	PF15093	DUF4555		Domain of unknown function (DUF4555)	Bateman A	agb	Jackhmmer:Q8N865	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa.This family includes the human protein C7orf31.	27.00	27.00	75.20	64.90	25.50	23.70	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.96	0.70	-5.51	4	43	2012-06-28 11:56:23	2012-06-28 12:56:23	1	1	32	0	29	47	0	246.30	53	49.21	NEW	MtsTtshP.....hh+Es.ulshLSsTahSs-LaoPLpospR.TssEspappaRtplt+ss...+sP....WGpc+.cYGGhtPl.LPspaRPKsEPPphVtKuH+HYGSGhp.aP................cthPlpQ.YphTp.phSclRhNDpLLPpP.puslhsh.lctPaPtEHPYtSHIs+hulFPs.sSPc-..ttltstpp......PhPspsPTpP.p.hl..Ko+GsPaRaEl.Dhspcs.+++ALsW.GpssYp.hptssptsR..hYPtPPKohtPN.s.ps.hs.ths.+pssshRslcKSthhToYppc	...........Mtshpshs....hhp+EhpGsDlLSsTahSNclaTPLppshRsT..sSpcRYpELR-oLpps....RLP....WGu-R.EYGGlhPloLPE-H.RPKsEPPplMuKGHpHYGFGG-sW..P............................................................................................................RclPIEQaYaLTQsKKSclhsNDSLlPKPP.sS.sltc..IshPaPlEHPYpTHIsRsAMFPoFsS.PcDhhTGlcARsp.....QPFPPTlPT.....KsaDsslL.KT+GNPYRa.EllDhPhDS.KKKALsWPGQslYashP+sspKs+.lF...YPKPPKohAPNoohps.hDsh.sh+pANIpRNLERSpWlToYs+..........................................	0	11	11	15
+14945	PF15094	DUF4556		Domain of unknown function (DUF4556)	Bateman A	agb	Jackhmmer:Q8N9H9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. This family includes human protein C1orf127.	27.00	27.00	36.50	36.30	18.80	17.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.45	0.70	-4.77	3	33	2012-06-28 11:58:33	2012-06-28 12:58:33	1	2	21	0	11	33	0	196.40	68	35.49	NEW	+CPMhsARLGcESV+CcPpFIQVSRPlPhhsDusQTPWLLSLRGELVASLEDASLMGLpVDlGATsVTVQSPRQELLQR.E.........PLhhVSGuhhh.hpQAlPLVSpQPtSEVuVHIPKQRLGLVKRGShlEEoLS.RFLcVpQo-oFpVs...Es+DFVlVSIPouslLQsQsCQcuc-oPGTQAFYRVDLSLDFAEMAuPVhWTVEsFFQC	.....KCPMlpSRLGQESVHCGPhFIQVSR.PLPLhpDspQTPWLLSLRGELVASLEDA.SLMGLYVDlNATTVTVQSPRQsLLQRhE.............VSGt.....psAhP.s...VShQPESEVLVHIPKQRLGLVKRGSalEETLSLRFLRVHQSNhFhVT...EN+DFVVVSIPAAuVLQVQpCQEssGoPGTQAFYRVDLSLEFAEMAuPVLWTVESFFQC......	0	1	1	2
+14946	PF15095	IL33		Interleukin 33	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95760	Family	\N	27.00	27.00	78.10	27.40	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.77	0.70	-4.94	4	41	2012-06-28 12:02:12	2012-06-28 13:02:12	1	2	23	1	13	44	0	204.20	59	97.66	NEW	MKYSTsKISPAKhpsoAuKALV.ssKLRKSQQKscEVCphYaMpLRSGLhIcKcsCYFRKEsTKRaSL+o..tpptpppthslsuppcphpt.......sFshth.hltsastuhthsSIph...lTEasASLSTYNDQSITFVLEDGSYEIYVEDLtKsQEKDKVLLRYY-SQpPSspoGDGVDG+pLMVNLSPTKDKDFhLHANsKEHSVELQKCEspLP-QAFFVLHcpSSpCVSFECKssPGVFIGVKDNpLALIKhtDpsps....NIhFKLS	..........MKYSssKhSsAKhpsoAu+ALs...Klt+SQQK.scElCphYaMpLRSGLhIcKcuCYFR+EhTKR.S.+o..tt....tthshsupppp..................h.thttth...t..Sl......lpE...ASLSTYNDQSloF.shEstuY.I.VEDhtKspcKDKVLLpYY-SQpsSsEo...GDGVDG+hLMVsLSPp..KDFhLHANsKEHSVELpKCEpsLPDQAFFlLHpp.....sSpCVSFECKssPGsFIGVKDNHLALIcs...-.opp.....NIhFKLS.......	0	1	1	1
+14947	PF15096	G6B		G6B family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95866	Family	\N	27.00	27.00	161.30	160.90	22.00	18.00	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.58	0.70	-4.83	5	39	2012-06-28 12:10:19	2012-06-28 13:10:19	1	1	24	0	16	49	0	203.90	70	89.65	NEW	NPGASLDGRPGDRVNLSClGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFuGRLRSLDoGIRRLELLLSAGDSGTFFCKGRHE-ESRTVLHVLGDRAYCKA.........PGPTHGSsYP+lL.IPLLGsGLVLGLGsLGhsaWR+RRlPPpP.cPhPRFA...PllsT......EuQRPl+EQDuKhPGcLDQEPuLhYADLDH.sLpR.RRhSsssPuDA.STVYAVVV	......ssGASL-G.RPGDRVNLSClGVSHPIRWsWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFsGRLRSLD.sGIRRLELLLSAGDSGTFFCK...GRHE-ESRTVLHVLGD+s.C+s.........PG.PT..HGSsYPQlL.IP...LLGAGLlLGLGALGlVWWh+R+.PPt........Ph.P+hA.....Phsps..........................EsQ+..ss+..c.p-s+hsGc.D...p.EsuLhhu.............s.h.stc..sTl.uhss................................	0	2	2	3
+14948	PF15097	Ig_J_chain		Immunoglobulin J chain	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P01591	Family	\N	27.00	27.00	75.90	57.10	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.95	0.71	-4.57	4	36	2012-06-28 12:14:02	2012-06-28 13:14:02	1	2	26	0	21	57	0	126.70	71	78.70	NEW	-DEpTVLVDNKCpCsRlTSRIIPSs-sPsEDIVERNIRIIVPLNsRENISDPTSPLRTpFVY+Lo-LCKKCDPVElELssQlhpAoQSNlCsEDs...ETCYTYDRNKCYTThVPhsY+GpT+MVpAALTPDSCYPD	..EDEchVLVDNKCpCsRlTSRII.Ss-DPsEDIVERNIRIIVPLNNRENISDPTSPlRTcFVYHLS-LCKKCDPsEVEL-NQlVTATQSNlCDEDs...ETCYTYDRNKCYTssVPLsYsGcT+MVpTALTP-SCYPD.	0	1	1	6
+14949	PF15098	TMEM89		TMEM89 protein family	Bateman A	kh6	Jackhmmer:A2RUT3	Family	The function of this family of transmembrane proteins, TMEM89, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are approximately 159 amino acids in length.	27.00	27.00	162.40	44.70	20.00	18.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.87	0.71	-4.14	5	25	2012-06-28 12:19:38	2012-06-28 13:19:38	1	2	22	0	14	28	0	126.50	69	84.98	NEW	WSRPLWYQVGLDLQP..........WGCQPNSLEGC+uSLGCPGYWMGLGuNRIYPVAGVTITTTMMLllSRslhQRRRSQAoKuEHPQVTssPCssWKRR.uPISDRTLLLGVLHMLDALLLHIEGHLQ+LAoQcQIQIKGTPs	...WSRPLWYQVGLDLQPWGCQPsSlEGCcuuLuCPGYWhGLGus.RIYPVAGVhITTTMMLlhuRhlhpRRRSQATKu..EHPQVTTpPCGPWKRR.sPISDRTLLhGVLHMLDALLlHIEGHLQ+LATQpphQIKGTss..	0	1	1	2
+14950	PF15099	PIRT		Phosphoinositide-interacting protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:P0C851	Family	The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane [1]. Proteins in this family are approximately 140 amino acids in length.	27.00	27.00	39.00	38.00	26.80	26.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.85	0.71	-4.92	10	80	2012-06-28 12:20:04	2012-06-28 13:20:04	1	1	40	0	50	69	0	125.90	42	88.69	NEW	hssPsu.s-.shhEKssps........ssslslPLVsEsQLTAATGGAELSCYR...CTlPFGVVlLIAGIVVTAVAYoF...NSHGSlIShhGLVLLSuGLlLLAsSAlCWKsRhc+K+c+RRESQTALVsNpRslFs	..........................t..hPKs..pssphp.psps........ssshsls.h..SEspLTsATGGuEhShYR...CIhPFGsllLlhGlVlTuVAYoa..............Nops.....S...l...lphhGlslLShGLhLLssuhLCWpsp.++Kpt+RpcSphhhshpph.Lh.t........	0	3	6	17
+14951	PF15100	TMEM187		TMEM187 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q14656	Family	The function of this family, TMEM187, is not known, however it is predicted to be a multi-pass membrane protein. Members of this family are as yet uncharacterised. This protein family is also alternatively named ITBA1. This family of proteins are found in eukaryotes. Proteins in this family are typically between 239 and 267 amino acids in length.	27.00	27.00	36.50	34.50	21.20	24.50	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.62	0.70	-4.99	10	38	2012-06-28 12:20:47	2012-06-28 13:20:47	1	2	35	0	21	36	1	226.10	56	86.68	NEW	ALhHVslssCLClulshTGlFDuVhV-lGY-HYAEpPVss...LPuaLAMPFNSLVNluYlLLGlYWLpppsssspsst.............cAcYlKDVFAhMAlsYGPVQWLRlsTQpRssAVLDQWhTLPIFAWlVsWC.aL-+..GW+sphhLulEslSlsSYuLuLLHspGFElA.LGhHIssAVhpulp....sQtRaGs.ssStpYLsLAVLSCuGFVVLKLhDHpLA+a..cLFQpLTGHFWSKVCDlLQFHauFpFLTs	.........................................................................................................AhhHVAluusLCsssVaTGlFDuV.V.pVGYEHYAEsPVsu...LPAFLAMPFNSLlNlAYsLLG.laW.Lp+ssss.stss................+YlKDVFAuMAL.....lYGPVQWLRls....TQh+hsAVLDQWhTLPIFAWsVAWChaL-+.....GWcPWhhL....ulEslSLsSYuLALLHPpGFEVA.LGsHlsu...AVupAL+......................spp+aGs.ssSspYLsL....GlLSCL.GFVVLKLhDHpLApW..pLFQpLTGHFWSKVCDVLQFHFAFlFLTp................	0	7	9	11
+14952	PF15101	DUF4557		Domain of unknown function (DUF4557)	Bateman A	agb	Jackhmmer:Q8NHR7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved TVF sequence motif.	27.00	27.00	27.20	27.10	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.26	0.70	-4.49	5	40	2012-06-28 12:20:57	2012-06-28 13:20:57	1	1	29	0	25	36	0	188.00	62	92.08	NEW	FpuQ+AWFSuSVSpDlpphWVcEGGsISD.s+sADFLFSsDASHsDTtRIYpS-DYlcDpATVFHupaLtAssNscSpsSVs..LGHYVL.........PP-s............lQcElRuKIGSF.IWEQDEpFl....lp+c-chsPsc...pslpcpupsos-Hspcpp+Ss-aatTRTslscKspsash+s................YPVNNM..VoGYlSIDAhcKa.GE..L+DFlPGsuGahVh+sscs	......FQGQRGWFCsSVSp-LRQFWVAEGGoISD.s+AADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANA..EI..KsSVA..LGHFlL.........PPAC............LQK.EIRRKIGSF.IWEQDp+Fl....lcKHDEVsssE..lcshpEsS.cluT-HcKELScSsE+HhhRTPVlEKQMYFPLQs................YPVNNM..VT.GYISIDAMKKFLGE..LHDFIPGSSGYLAYHVQsE............	0	4	5	6
+14953	PF15102	TMEM154		TMEM154 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6P9G4	Family	The function of this family of transmembrane proteins has not, as yet, been determined. However, it is thought to be a therapeutic target for ovine lentivirus infection [1]. This family of proteins is found in eukaryotes and members are typically between 138 and 320 amino acids in length.	30.30	30.30	30.30	30.30	30.00	29.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-11.17	0.71	-4.49	7	50	2012-06-28 12:21:22	2012-06-28 13:21:22	1	6	36	0	27	44	0	129.00	39	50.53	NEW	sE-sppSuc.slpstsh.csos...................soshuoVT.sE.....slssshs.sph...pssssQhEh...............lLMlllP.llLsLLlL.llhllhhh+R+RsKpc..p.spppt...p-lssEslh.P............IFEEDTPSVMEIEMEELDKWMNSM.....N+NADhEsL	................................................................................ph....................sshsulT.sp.....slssshssop..h....st-ps..QhEF..........................lLMVlIPh.lLLsLLlLsV.lhlshhh.+RKRs.Kp-soSpGSpssLQ.o.E.lusEsl+sP............IFEEDTPSVMEIEMEELDKWMsSh.....N+Nssh-t......................................	0	6	9	14
+14954	PF15103	G0-G1_switch_2		G0/G1 switch protein 2	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P27469	Family	This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers [1].	27.00	27.00	66.30	66.20	21.80	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.47	0.72	-3.79	8	46	2012-06-28 12:22:18	2012-06-28 13:22:18	1	2	34	0	23	43	0	103.30	54	90.29	NEW	METlpELIPhAKEMhuQKPSRKhVKLYlLGSVLAFhGsVlGLVETVCSPFTuupcL.DpEtA..lAEhcsAhERptlppp...........slhEcsKpppss.psRulSpRpHA.S	METlpELIPhAKEMhuQKPstKMVKLYVLGSVLAhFGVVlGLVETVCSPFoutupL.DpEtt...lsEhcsA..htRpthppp......................hlhEpuKppsss.tpRulSpRpHAS..............	0	1	3	9
+14955	PF15104	DUF4558		Domain of unknown function (DUF4558)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VU69	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 78 and 121 amino acids in length. One member is annotated as being a flagellar associated protein.	27.00	27.00	27.40	27.00	26.20	26.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.86	0.72	-4.06	11	43	2012-06-28 12:22:34	2012-06-28 13:22:34	1	2	40	0	28	44	0	85.30	39	79.28	NEW	pchsptcchspc.cpssphs.WpEphppp....ssht.sspph...pcphcpElplAN+plhtlRpAtL+cLaEcEtppaEQELstpGhAhYccRt	..................pchhthcKhlp+hcssppcshWp.sLspR......cssh.Ahl+h...pcshspELsLAsKpLLhVRQAtL+pLFE+EappYpQELsph.GKAFYhER....	0	10	15	16
+14956	PF15105	TMEM61		TMEM61 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N0U2	Family	The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 150 and 211 amino acids in length.	27.00	27.00	27.80	41.90	25.60	23.80	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.28	0.71	-4.78	3	25	2012-06-28 12:22:48	2012-06-28 13:22:48	1	2	21	0	12	21	0	172.70	63	95.11	NEW	ASTLRYCMTVSGTVVLVAGTLCFAWWSEGDAusQPGQLAPPTEaPlPEuPsPLLRSVSFlCCGAGGLLLLlGLLWSIKsST+GPPRtDPYHLSRDLYYLTVESSEKESYRsPKVsAIPTYEEAVsCPLAEGPPTPPAQPsEEuLEs+AScDALLGoQss.PPPSYESIlLAtsAVSGpTs..PSPGpSCsGLlQsARGGs	.ASTLRYCMTVSGTVlLVAGTLCFAWWSEGDA......usQPGQhA...P....P.TtaPlPEuPusLLRSVSFhCCGAGGLLLLhGLLWSlKASopGPPRWD.YHLSRDLYYLTVEoSEKESCRoPKlssIPTYEEAVsh..PlA..EGP.PTPPAhPhEEsLcsSA.....stDALL...........uTQsshPPPSYESI.hAhsulSuETs...usstoCsG.sphstGG.......	0	1	1	4
+14957	PF15106	TMEM156		TMEM156 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N614	Family	The function of this family of transmembrane proteins, TMEM 156, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins are found in eukaryotes. Proteins in this family are approximately 310 amino acids in length. In humans, the gene encoding this protein is located in the chromosomal position, 4p14.	27.00	27.00	61.40	61.10	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.47	0.70	-5.12	6	34	2012-06-28 12:23:08	2012-06-28 13:23:08	1	1	28	0	19	29	0	213.80	56	78.32	NEW	EVCLQsNFTaSLsSlNFSFVTFLQPl+ETQTI.MGIFLNHSNFQNFTcICQsITuEhKhCSsCLsCESKGshDFISQEQTS...KVLlMRGShEVKusDFHSPCQHFNFTsAPhsDcLEEYNhTCpLKTHssRSsIhEE-Ps+EpSlN+TC..RhMEp.NNChpISL+LEMDVKNssCSMKITWYlLVLLVFIhhlIllI+KILEuHRRVQKWQSHKYKPTSsLLRGuDSEK	..EVCLpsNhTYSLsSlNaSFVTFLQPlRETQsI.htIFLNHSNFQNFTRICQsITuEhKhCSpCLlCESKGshDFISQEQTS.................KVLIh+GShEVKAsDFpSPCpHFNFTVAPhVDcLEEYNsTCpLKsHTt+SslhE--Ps+cpSlN+TC..RhMEh.NsCh+ISLHLEMDlKNhoCSMKITWYlLVLLVFlFLlILhI+KILEuHRRlQKWQ..S..H+.+sTS.sLLRGpDSEK..................	0	1	1	3
+14958	PF15107	FAM216B		FAM216B protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N7L0	Family	The function of this family of proteins, FAM216B, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins are found in eukaryotes. Proteins in this family are approximately 150 amino acids in length. In humans, the gene encoding this protein is located in the position, C13orf30.	27.00	27.00	35.30	35.70	25.80	24.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.51	0.71	-4.20	6	56	2012-06-28 12:23:32	2012-06-28 13:23:32	1	2	26	0	25	61	0	106.40	50	55.52	NEW	Mspchp+.QcLhNlP+IPpI+VPpShsDTSLLK..DLTQGQpRYhYSIMRIYNSRPQWcALQsRYlHSLQHQ.QhLGYITQ+EAhusAhVLRcST+RASApsuP....Rol.pRssuho	..........hsppht+.QcLWpsPQ..pI+lPpShh..DsShhK..DLTpGQpRYhhSIh+IYNup..hphhpppYhHsLQHp.Q+...G.........hlTp+cuhhs.......o+huptphhP....Rp..c+psuh.......................	0	2	2	3
+14959	PF15108	TMEM37		Voltage-dependent calcium channel gamma-like subunit protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8WXS4	Family	This family of transmembrane proteins, TMEM37, has a role in stabilising the calcium channel in an inactivated (closed) state. It is a subunit of the L-type calcium channels. This family of proteins are found in eukaryotes. Proteins in this family are approximately 210 amino acids in length.	27.00	27.00	123.00	122.80	25.00	24.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.36	0.71	-4.59	6	38	2012-06-28 12:23:58	2012-06-28 13:23:58	1	1	31	0	23	39	0	179.50	68	93.16	NEW	QAQRLLupRRPp+uFFESFIRuLIILCsuLAVVLSSISICDGHWLLAcD+LFGLWaFCTsSNp...........ousHClRDLSpApVPGLAsGMlLARShuoLAVVsAIFGLELLhVSQVCEDhcSR+KWAhGSsLLLlSFlLSuGGLLSFlILL+splTLhGFTLMFWCEFTASFLFFLNuISGL......HINSlTpP	..........QAQR.LuQR+PpRSFFESFIRoLIIlCsALAVVLSSlSICDGHWLLA.ED+LFGLWHFCTsoNp...........osspChRDLupApVPGLAVGMuLsRSlGALAVVAAIFGLELLMVSQVCEDtHSRRKWuhGSlLLLlSFlLSSGGLLoFVILL+NQVTLlGFTLMFWCEFTASFLFFLNAISGLHINSITpP.......	0	1	3	7
+14960	PF15109	TMEM125		TMEM125 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q96AQ2	Family	The function of this family of transmembrane proteins, TMEM125, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 55 and 232 amino acids in length.	27.00	27.00	30.80	63.40	22.50	20.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.54	0.71	-3.96	6	45	2012-06-28 12:24:17	2012-06-28 13:24:17	1	1	33	0	25	36	0	109.40	73	53.85	NEW	slLEEQVELWWFp-P++SLLCYssuVsLILuCGhGGVGLLSTToShSGE...WRLusGTsLCLLALsVLLKQLLSSAVQDMNClRsR+RI-hLKSGGhuDsLllLloGLsLLlCG	.slLsEQVELWWSQpPRRShLCFsVAVuLVsGCGAGGVuLLSoTSSRSGE...WRLAsGTsLCLLALLVLlK.QLhSSAVQDMNCIRpt+HVuLLRSGGGADsLVVLlSGLVLLVsG	0	1	4	11
+14961	PF15110	TMEM141		TMEM141 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q96I45	Family	The function of this family of transmembrane proteins, TMEM141, has not, as yet, been determined. Members of this family remain uncharacterised. TMEM141 protein family is found in eukaryotes. Proteins in this family are typically between 103 and 124 amino acids in length. There are two completely conserved residues (C and W) that may be functionally important.	27.00	27.00	27.00	34.80	20.00	26.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.16	0.72	-3.70	12	53	2012-06-28 12:24:45	2012-06-28 13:24:45	1	1	44	1	29	54	0	88.90	47	74.94	NEW	ssI..p+lc-t.tsKHPGhspYhs......C.o+AhhpGluTFsLGhuusahlQ+hlp++lPYPhpaNlLVSslsuoVsSYpVTphcTppCpshWhhhEstp	............l..p+lcDt.tsKHPGhtpYhs......C.S+AhhcGlhTFlh.GouusFhlQhhlp+KhPYPhQWslLVusls..uSluSYtVTpsEop+CsslWlaLEsG.p..........	0	7	10	17
+14962	PF15111	TMEM101		TMEM101 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q96IK0	Family	The function of this family of transmembrane proteins, TMEM101, has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 257 amino acids in length.	27.00	27.00	37.30	30.80	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.54	0.70	-5.08	7	47	2012-06-28 12:25:10	2012-06-28 13:25:10	1	1	42	0	29	47	0	235.60	71	95.47	NEW	ssR+phLphhsplGsFllTRaPFWpsFshLMhaAERA-s++hP.....DltlP...al.YlDLusAVlCASFMSFslKRRWFAlusAlQLs.ISshhuhhutpshYu-WLKVRhaSRslAlIGGaLhluSGsGEhYRp.KPRoRSLQpTGplFLGlYLIC.AYsL.aS+EDRhAaLpHIPGGp.hl.lhhVlaslLuLuaLSGa.hphhuplLAllLshshLllDGslsYWa+o+.+VEFWsQh+LlucNluIFGAllIL..AsDu	.......u..R+hhLpLlhQlGuhLLTRhPFWsCFS.LMLaAERA-u+RKP.....DIPVP...YL.YF.DMGAAVLCASFMSFGVKRR.W.FALGAALQLA.lSTYAAYlGGaVHYGDWLKVRMYSRTlAIIGGFLVLAS..GAGELYR+.KPRSRSLQSTGQVFLGIYLICVAYSLQHSKEDRLAYLNHLPGGELMlQLaFVLYGVLALAFLSGYYVsLAAQILAVLLPsVhLLIDGNluYWHsTR.RVEFWNQMKLlGEsVGIFGAAVIL..ATDG.........................	0	7	9	13
+14963	PF15112	DUF4559		Domain of unknown function (DUF4559)	Bateman A	agb	Jackhmmer:Q8TB03	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes human protein CXorf38.	27.00	27.00	65.20	27.60	25.40	23.40	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-11.92	0.70	-5.26	8	62	2012-06-28 12:25:15	2012-06-28 13:25:15	1	7	37	0	32	49	0	241.90	51	64.70	NEW	RhNstsYKNWLKsGpuLLlLRsuLQsFlt+EscsaHpuLpsKlss..ssppCp....Css+uRp.pstCplCc.W+cEIlpaHsscsucIHWsNCcPstW...ss-hWEVAKAFMPRGp.sD+sGPEcsDsSALLNFlstCcHFph...chcpVpcVIcVRNclMHSsDLKhSspshpcahsKIpphlp...hsslPslptstccIpplpss-apltssptspcDGsclpT-sh.shpclL-lEpctLcD+lpcLhsphEpsps.s.Echhpslpslh-FLpsNpDLppsLpscl.......sKLpplps+lpKh-tpls-l+sphsQL	..................RLNsspYKNWlKAGpCLLlLRssLpsFlspEshsFHptLlsthss......spssCpt..tCsP+u+phpspCpl...CtpW+pEILpHHhscsus...lpW.uNCcPshW...ss-...WEVA......KAaMPR..Gh..sc+pu..s-pCDAsALLshlstCc+Fhs...DtcpVpc.VIcsRNc.lMHSu-hKVSstWhp-at.+IpsFLs..pFpplP-lssshp+IEplLssDaslahsttDphD.....Ghch-htshls.pp....lp..-lEhphL+E+LpEhhhphccpphhs..Ec..pplpsltpFLcpNcDLppsLpt-h.......pKLpsh..p.phtp...............t...................................................	0	6	9	16
+14964	PF15113	TMEM117		TMEM117 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H0C3	Family	The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 504 amino acids in length.	27.00	27.00	32.60	32.60	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.54	0.70	-5.88	4	63	2012-06-28 12:25:37	2012-06-28 13:25:37	1	2	39	0	38	51	0	317.70	70	79.75	NEW	t+DFRYYFQHPauRLhVAYLVlFhNFLlFAEDPVSHSpTEAplIVVGNsFSFlssKYP.GhGWplLKVlhWLLAllhGLlsGKFlhH+hLFGpLLRLKMFREDpGSWMhMFhoTllFLFIFSpIYNhhLLhAGs..tsahIoDhMGIRNpSFMKhAAlGTWMGDFVTAWMVTDMMLQDp.YPsWA+usRtFW+p.GpsRIILFWoVLloLToVVVhVIoTDaISWDhLNRGFLPosElSRAFLASFILVhDLLIVMQDW-FPHFMGDLDlpLPGhpTsHh+h+lPhppplaK-EapIHITGKWFNYGIIhLVlILDLNMWKNQIFY+Pa-YGQYlGPssKIaTVc-.-oLts..hNRTpLTa-WRuNphsPcTNcoYlEcDhahHSRYlGhoLsVKsLAFlPSLhAFVhFGhhIWhaGR	..........................s..cFRYYFQHPWSRhllAYLVhFhNFLIFAEDPlSHSQTEAphhVVGNCFS..FlhsKYP.uhGWthLKVlhWl....LAIlhGLlAGKFlFHp...pLFGph....lRLKMFpED.cGSWMsMFhSsllhLFhFSplYNhhLlhtGs.htsahlsphMGIcNpsFMK..hAAlGTWhGDFlTAW.M.VTDMMLQDp.......YPDWG+uAR.....tFWK+..Gp.RIhLFWoVLhoLTSVVVLVIoTDWISWD+L.......NRG.....FL...PSDEVSRAFLASFILVFDLLIVMQ.DWEFPHFMGDlDl.NLPGLpTsHhpF+lPhhp+IFKEEY+IHITGKWFNYGIIFLVLILDLNMWK.NQIFYKPaEYGQYlGPGp.KIYTVcDsEoL+D..hNRTpLSWEWRSNpTNPpTN+TYsEuDMFLHSRahGuSLDVKCLAFlPSLlAFVhFGFFIWFFGR.................	0	8	12	19
+14965	PF15114	UPF0640		Uncharacterised protein family UPF0640	Bateman A	agb	Jackhmmer:Q8WVI0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 70 and 80 amino acids in length. There are two conserved sequence motifs: PGK and YRFLP.	27.00	27.00	66.50	66.40	26.60	25.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.37	0.72	-4.50	10	56	2012-06-28 12:25:59	2012-06-28 13:25:59	1	1	50	0	38	56	0	68.10	56	89.06	NEW	Mhh.+..Spsl+plLcpWPGK+phGlYRFLPlFFsLGAuhEasMINhRlGcpsFYcsY+R+QAE+hhEp+hcp	.................h..ptpl+RlLpphPGKpRFGlYRFLPhFFVLGushEWhMIplR.V.Gc.EoFYcsY+R+puEc.hpc+lcp......	0	7	11	22
+14966	PF15115	HDNR		Domain of unknown function with conserved HDNR motif	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VZQ5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 219 amino acids in length. There is a conserved HDNR sequence motif. The function is not known.	27.00	27.00	35.40	35.30	20.10	19.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.34	0.71	-4.34	6	73	2012-06-28 12:27:26	2012-06-28 13:27:26	1	2	36	0	47	64	0	150.10	36	84.54	NEW	Ms+uhh..ssssctcGpWFsphh........cuHhsoph+psas..apc...pscspsPshFtpRpKpssspph........FShHDNRHoFpspGs...YFssGLGK++hs.sp.....p+t+.SpNhhpWss..hsuspDs..hSoYpsuaht.......cpss.ssthRphPRhhscp.puuphtssppsspa..hsppPcs.........chslstpsp	.......................shsGpW.asphh.........puhh..puphKp.psschpp...pscsp.PslathRpKpsssppF.........FShHDNRaSapssGh...Y.L.spGlG.RKpl........p+.t.p+sF.hWAss...l..p.p.t...Ss.Qhsah.......................................................................s.................................................	0	11	12	17
+14967	PF15116	CD52		CAMPATH-1 antigen	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P31358	Family	\N	27.00	27.00	40.70	40.10	19.80	17.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.08	0.72	-4.15	4	22	2012-06-28 12:27:31	2012-06-28 13:27:31	1	1	17	0	8	20	0	44.90	48	65.52	NEW	LGpsTTut.sop...........+SussAhusLuGGShLFFlANTLIpLFYLS	................GpssTot.........................pSussA.SsluGGsFLFFlANslIpLFhhS	0	1	1	1
+14968	PF15117	UPF0697		Uncharacterised protein family UPF0697   	Eberhardt RY, Coggill P, Hetherington K, Bateman A	agb	Jackhmmer:Q96E16	Family	This family of uncharacterised proteins is found in vertebrates. Proteins in this family are typically around 100 amino acids in length.	27.00	27.00	61.40	61.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.29	0.72	-4.23	4	50	2012-06-28 12:28:25	2012-06-28 13:28:25	1	1	39	0	30	41	0	93.30	77	93.22	NEW	uDsGoIDYSVHEAWNEATNVYLlVILVShuLhMYAR+NKRKIMRIFTlPPTAEossEsNFYDohpKIRLRQQLEMYSIARKa-.Q..Q...tQsDSVQLSlE	....uDDGSIDYoVHEAWNEATNVYLlVILVSFGLFMYAKRNKR+IMRIFSVPPTtETLS...EPNFYDTlSKIRLRQQLEMYSISRKYDhQ.QPQ...sQuDSVQLSlE..........	0	2	4	12
+14969	PF15118	DUF4560		Domain of unknown function (DUF4560)	Bateman A	agb	Jackhmmer:Q96HG1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 66 and 78 amino acids in length. There are two conserved sequence motifs: FCK and RTL.	27.00	27.00	74.90	74.70	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.99	0.72	-4.17	5	46	2012-06-28 12:30:52	2012-06-28 13:30:52	1	1	23	0	30	64	0	62.80	76	75.50	NEW	AsALSGLAVRLuRoAAsRuSYGVFCKGLTRTLLsFFDLAWRLRMNFPYFYIlASVILNVRLQV+I	........AAALSGLAVRLSRSAAsRuSYGsFCKGLTRTLLsFFDLAWRLRhNFPYFYIlASVMLNVRLQVhI..	0	1	1	4
+14970	PF15119	APOC4		Apolipoprotein C4	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P55056	Family	\N	27.00	27.00	58.70	58.60	24.60	19.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.27	0.72	-4.02	6	27	2012-06-28 12:31:28	2012-06-28 13:31:28	1	1	21	0	14	24	0	92.60	62	78.88	NEW	CQ.t.sEto.SPsPtPcpS+.WSLVPu+VKEhVpPLVTRTRE+WQWFW..GPuAFQGFhQTYYDDHL+DLGsRT+AWLpSSKDsLLNKAHSLCPRLlCGD+D	.....................................h.pto.SPsPt.c.Sp.WSLVpu+hKEhlEslVsRTR-pWQWFW..uPusFpGFhQTYY-DHL+DLGPRT+AWLhpSKDSLLNKTHSLCPRLlCGD+D..	0	1	1	2
+14971	PF15120	DUF4561		Domain of unknown function (DUF4561)	Bateman A	agb	Jackhmmer:Q96E40	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	34.30	33.30	24.10	21.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-10.90	0.71	-4.79	6	65	2012-06-28 12:32:32	2012-06-28 13:32:32	1	3	39	0	34	54	0	160.90	60	76.91	NEW	MsEl+cpL+hlpQ+YKLFpQQQFTFlsALERsREsAaD+hcPVuoIsQVQpYh-HaCsNuTDRRILhLFLDICsDLsshpp+lEsLp......SssssosphL-pC+sLls.SNDlSslRA+YPHDVVNHLSCDEARNaYGGVVSLIPllLDhlpEhht..psc+Lt.tpp.ssstppp	................MNEVKEsLRslEQ+YKLFQQQQFTFIAALEHCRENA..HD...KIRP.ISSIuQVQsYMEH....aC.....NNSTDR.....RILlMFLDICoELs+LCQ+FEuLH................SGTPVTNsLLEKCKoLVSpSNDLSoLRA...KYPHDVVNHLSCD........EARNHYGGVVSLIPllLDlhKEWIA..+oEKLPp...........th...t.........	0	8	10	18
+14972	PF15121	TMEM71		TMEM71 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6P5X7	Family	The function of this family, TMEM71, is not known, however it is predicted to be a transmembrane protein. This family of proteins is found in eukaryotes and located in the cell membrane. Proteins in this family vary between 41 and 291 amino acids in length.	27.00	27.00	27.00	39.90	26.90	26.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.98	0.71	-4.47	10	47	2012-06-28 12:32:51	2012-06-28 13:32:51	1	1	32	0	21	39	0	131.30	62	55.16	NEW	MY..phStlhSTPVussopp-tththp.SPsslhsSasCD.LD......GDSSFECsSlDPLTGShasCRRSPRLLTNGYYlWTEDSFLCDcDGNITLoPSQTSVhYKENLVRIFR+K+Rh+RSLuSLhS..hpAScSWL+GSIFscV................sSsPSEDsWLEGsRp	............MYRlopLMSTPlASpst....pt..tphosp.plhsS.FsCD.LD......GDpSFECsSlDPLTGSaasCRRSPRLLTNGYYlWTEDSFLCDcDGNITLsPSQTSVhYKENLVRIFR++++hp+shuSLFs..lssScSWL+uoIFscl................cS.s.sEDsWL-Gh+p......	0	1	3	6
+14973	PF15122	TMEM206		TMEM206 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H813	Family	The function of this family of transmembrane proteins, TMEM206, has not, as yet, been determined. Members of this family are remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are approximately 350 amino acids in length.	27.00	27.00	149.50	149.10	19.20	16.40	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.82	0.70	-5.51	3	51	2012-06-28 12:34:56	2012-06-28 13:34:56	1	2	39	0	31	44	0	287.80	75	84.57	NEW	PIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFRDKLKHPVMSVSYKEV-cYDAPGIALYPGKA+LLSCcHHaYDsIPPLsuPGQPG-RsCsTQ-IsYpcPYoN+TMK+ALIVQGPpDVR+RELVFLQF+LNETcEDFSAIDYLLFSSFc-FLcSsDKAuFMQDCESuYSSWKFSGGFRTWVKMSLVKTKEEDGpESVEFRQETSVVNYID+RPssE+osQLFFVVFEWKDPFIQcVQDIITANPWNTIALLCGVFLALFKAADFAKLSVKWMIKIRKRHLK+RuREhNHIS	..........SIRFSKACLKNVFSVLLIFIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEV.DRYDAPGIALYPGQAQLLSCKHH.Y-VIPPL..suPGQPGD....hsCTTQRINYTDPFSNQThKoALIVQGPpEVKKRELVFLQFRLNposEDFSAIDYLLFSSFQ..EFLp...S.........P-+sGFMQuCESAYSSWKFSGGFRTWVKMSL.VKTKEEDGREAVEFRQETSVVNYIDQRPAAE+SsQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRaLK+RuQAsNHIS.........	0	2	4	12
+14974	PF15123	DUF4562		Domain of unknown function (DUF4562)	Bateman A	agb	Jackhmmer:Q96LM5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved HRYQNPW sequence motif. This family includes the human protein C4orf45.	27.00	27.00	41.50	41.10	18.10	17.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.46	0.71	-4.21	9	43	2012-06-28 12:35:21	2012-06-28 13:35:21	1	1	30	0	24	42	0	109.70	47	59.28	NEW	lFTGPDhl+Dahs+lhpassYIG.tp.u.EtTuDLpYLWRPAsspshPhthKpchlGEIGWGIs.ashhs+p+Lpo....GhpIKhGEhppAs.D+hTHRYQNPW.Pt...P.hl-tpsthuR	....lFTGPDYl+DahPKlppaTsYlGEpp.uLEpTuDLcYLWRPAsspShPschKacYVGEIGWGlPpasalN+oRLpo....GFpIKhsEhppAu.DphoHRYQNPWQPpPplhDhpst.S.............................	0	10	11	13
+14975	PF15124	DUF4563		Domain of unknown function (DUF4563)	Bateman A	agb	Jackhmmer:Q96PS1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes the human protein C3orf24.	27.00	27.00	120.30	27.30	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.23	0.71	-4.70	3	35	2012-06-28 12:37:45	2012-06-28 13:37:45	1	2	29	0	24	35	0	167.80	73	99.93	NEW	MAsYQLWSPWSPLDENLQWLRHTTPThuSKHPFRuSPsFPaTPuDVEVQtCFHEVslVpDpPhlcAG+SPcLPsHshEP+..ThsNhpupIRKPQPIRLlGVDSVFGRVITuQPPKWTGTFRVS-KSAFSKIIS+EpQWPpGLKEPQIEMTlsMCKQMLRSILLLYAIYKKCTFALQHSK	......MAGYQLWSPWTPLDESFQWLRHTTP...TPSS.KHPF..RASPCFPHTPSDLEVQLCFQEVTLVLDSPhLEsGhSP..KLPC........HTSELR..ThsspKGLVRKPQPVRLSGVDSVFGRVITAQPPKWTGTFRVSDKSAFCKIISREHQWPTGLKEPQIQMTVTMCKQMLRSILLLYATYKKCTFALQHSK...................	0	1	2	10
+14976	PF15125	TMEM238		TMEM238 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:C9JI98	Family	The function of this family of transmembrane proteins, TMEM238; has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 61 and 153 amino acids in length.	27.00	27.00	29.80	29.30	26.10	25.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.25	0.72	-4.07	9	40	2012-06-28 12:38:05	2012-06-28 13:38:05	1	1	24	0	26	43	0	67.20	55	48.09	NEW	GRCphhhh.lAVlhDslGlslLLlGlFAsL.....sFaDhLlYoGALllhLSLlhWlhWYoGNIE..ls.cEL	....GRC+hhLh.LAVshDlsGhssLLsGVFApL.....sFhDhLlYoGALllFLSLLhWIhWYTGNIE..lohpEL.....	0	2	6	13
+14978	PF15127	DUF4565		Protein of unknown function (DUF4565)	Bateman A	agb	Jackhmmer:Q9BSF0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  This family includes the human protein C2orf88.	27.00	27.00	35.00	35.00	22.80	18.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.07	0.72	-3.65	5	31	2012-06-28 12:40:36	2012-06-28 13:40:36	1	1	29	0	18	24	0	91.00	58	99.30	NEW	MGCMKSKcphPhssThcu-K.....s+cuEEAa..tchh..........lsssEEs+cPsuPp..huPVLLEYAcRLSEEIVs+AVQQWAElDp+YuDIPYIESDuP	MGCMKSKQTFPFPTshEuEK.....pH-SEEsF.MPEE+hL.+....st.lslpEElKcP..suss....sVlLEYAHRLSQEILsDALQQWAssNlKYtDIPYIESEuP.	0	1	2	4
+14979	PF15128	T_cell_tran_alt		T-cell leukemia translocation-altered	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P57738	Family	This family of proteins is required for osteoclastogenesis [1].	27.00	27.00	43.00	32.50	20.20	24.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.26	0.72	-4.54	4	48	2012-06-28 12:40:48	2012-06-28 13:40:48	1	2	35	0	24	42	0	84.70	61	85.78	NEW	opllsuh.uFhSEFlc-W.usDMRVoIFKlLLuWLVlSLlAIphAW+sYGNTVNshYYRQGhuGQNGGTPDsss+hsuWEpuus-sLKTHpE	.......splLsuLsuhuSEFlcEWEApDMRVoLFKLLLhWLVLSLLuIQLAWthYGsTVTGLYaRs................GhG.G..QNGuTPDsusHFsuWE.susEshKTHRE.....................	0	2	4	9
+14980	PF15129	FAM150		FAM150 family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6UX46	Family	This family of proteins known as FAM150 is found in eukaryotes. Members of this family are as yet uncharacterised. Proteins in this family are approximately 143 amino acids in length. The function of this family has not, as yet, been determined, however it is predicted to be a secretory protein family.	27.00	27.00	50.70	30.50	18.50	23.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.81	0.71	-4.24	6	65	2012-06-28 12:42:58	2012-06-28 13:42:58	1	1	30	0	34	58	0	92.10	66	77.03	NEW	-cpoLLcLIh-llp-hpppcpspspp....l..hupcspsss+ccsttlsshssEphlEIhPRDLpMKDKFlcHLT.GPLYFSPKCpKcFHRLYHNTRDCTIPAYYKRCARLLTRLAsSPhChE	.............................................................................................................................t.ppps..EIhPRDLphKDKFlKHLT..GPLaF.SPKCSKHFHRLYHNTRDCTlPAYYKRCARLLTRLAVSPhChp........	0	2	7	16
+14981	PF15130	DUF4566		Domain of unknown function (DUF4566)	Bateman A	agb	Jackhmmer:Q9GZU0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes human protein C6orf62.	27.00	27.00	177.20	61.80	18.70	18.30	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.68	0.70	-5.20	2	54	2012-06-28 12:43:17	2012-06-28 13:43:17	1	3	40	0	33	38	0	209.50	86	92.76	NEW	M.........uDP.oRKppslsRLRtpLR+K+ESLADpFDFKMYluFVFKDKKKpsALFEVs-VIPVMTNNYc-sIh+GV+-puYSLESS.ELLpKDVVQLHAP+YpsMR+DlIGCsQ.hDFhLWPRpDI-KIVChLFSRWKts.DtsaRPVQscFEFcHhDYEKQhLHlLuR+DpTGlllNNPoQShFLFlDRppLpTPpNKAshFKLsSlCLal.Q-QLhHWssGoI-chLc.YMP..p	................MGDPNSRKKQALNRLRAQLRKKKESLADQFDFKMYIAFVFKEKKKKSALFEVSEVIPVMTNNYEENILKGVRDSSYSLESSlELLQKDVVQLHAPRYQSMRRDVIG.CT...QEMDFILWPRNDIEKIVCLLFSRWKtS.DEPFRPVQAKFEFHHGDYEKQFLHVLSRKDKTGIVVNNPNQSVFLFIDRQHLQTPKNKATIFKLCSICLYLPQEQLTHWAVGTIEDHLRPYMP...E.................	0	3	5	15
+14982	PF15131	DUF4567		Domain of unknown function (DUF4567)	Bateman A	agb	Jackhmmer:Q9BTX9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in some mammals.	27.00	27.00	37.50	115.50	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.42	0.72	-3.84	4	11	2012-06-28 12:52:58	2012-06-28 13:52:58	1	1	11	0	6	2	0	75.90	76	84.43	NEW	pRLDEs.AsLRLQHaLQLtEGLAVPLPPLVVpuPAAHaVAGGuLuDFTLDIALGARRItLAhVRQVAQDGPVAFLA	.RRLDEsPAsLRLQHHLQLREGLAVPLPPLVlQSPAAHHVAGGShuDFTLDIALGARRVRLALVRQVsQDGPVAFLA	0	1	1	1
+14983	PF15132	DUF4568		Domain of unknown function (DUF4568)	Bateman A	agb	Jackhmmer:Q9H693	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	51.10	51.00	21.10	19.40	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.71	0.70	-5.13	4	25	2012-06-28 12:54:36	2012-06-28 13:54:36	1	1	20	0	13	23	0	132.50	44	81.24	NEW	GsGh.psWha.......GRs+h+sLschChu+hss.VspTVHpEsICCECpsKFGGaLPVPRA-AsLPYWVPLSLRPpKQIQKMVRhYIPKooKAC.CPCHpFGGRLPMPRDQAVMPYWVPQVLRSpKKVVKRQQshcslPEsslDlRShYspWRICG-G+hLLKWQQLQALHQsc..PlAsGpPtSh.AsLLPlshSLLTLLQAlLRVllAIRpLFWs	...................................................................................slCCECQs+FGGRLPVsRsEAALPYWVPLSLRPRKQh.+h..hph....................................................................................................................................................................................	0	1	1	2
+14984	PF15133	DUF4569		Domain of unknown function (DUF4569)	Bateman A	agb	Jackhmmer:Q9HAI6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  This family includes human protein CXorf21.	27.00	27.00	38.20	36.40	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.96	0.70	-5.03	8	57	2012-06-28 12:56:17	2012-06-28 13:56:17	1	1	36	0	37	43	0	279.10	45	97.54	NEW	MLuEGaLopLsYpsphcts....hpopsppsspppthcpp.ssh...shushDcsphcslhsuscsstch.uuVHspts.ps.p....tphlpsspsPshpussSsulcIPccs.cps.thaLVPS.SC..cSICpNYsDLHIuGDpVhslsssuGsh..ssssshpcGPlLhSsDIP.uhpsphps.sp.h....h.pshSShW+ssps+E+.ShL.ppc..PlSNSlLNsYLEpKlhELYKQYlhEsss+suSs........splLuSELlMTNVDQISlQlSREpNlEToKA+DhlLssL....LplsSph.pSEISTPsLpISs.us	................MLuEuaL.slhYhpphahs....hsshsppsstcct.cpp.ht....ohSSs-csp.cshhhpspossch.oolpsptsppshp..pphsslpss..ssshpuss.sAlpIs+csp+-p...aLVPs.SC..cSIC+NYsDL+IAGspVhshsssossF...scsshp.GPLLpSs-IPLshEsulssp.s.h..hsh.pphSShW+hsSI+EK.S.L.hpp..PlSNulLNcYLEpKVsELYKQYlh-slh+suSs........TplLASELlMosVDQISLQlSpEpNlEsoKA+DhVlspL....LphsS....oElSTPsLpISp.o..........	0	1	4	11
+14985	PF15134	DUF4570		Domain of unknown function (DUF4570)	Bateman A	agb	Jackhmmer:Q9HBI5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. 	27.00	27.00	29.00	28.70	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.43	0.72	-4.21	9	41	2012-06-28 12:59:01	2012-06-28 13:59:01	1	1	37	0	28	40	0	107.30	54	85.97	NEW	MsS.hsp........El+Luc+HEEILupRthLLppMEs+hpspppc+ppphpsspsAppRNtpLLpDl-ssEcpLpsR...hscPslluLETpYWASVEc......lPtWEpaLLuRu.hPhu	.............MoShasQ........El+LSKRHEEIlSQRLMLLQQMEs.+huDQpsE...KA.SQhQusEsAa+RNhoLLpDIEAAEKSL..QoRhaslPpP.ElVoLETpYWASVEEa.....lPKWEQFLLGRAsYPh.u.....................	0	5	7	11
+14986	PF15135	UPF0515		Uncharacterised protein UPF0515	Bateman A	agb	Jackhmmer:Q9NUL5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There are two conserved sequence motifs: PLT and HSC.	27.00	27.00	39.80	39.80	25.90	25.40	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.11	0.70	-5.33	4	53	2012-06-28 13:38:07	2012-06-28 14:38:07	1	2	34	0	27	52	0	227.20	68	88.44	NEW	REKFHG+lu.csAssLMRRasssHptVut.lshhscscssl-hpsphcLpssP.uh.V..thht--.ptpt..t......................D+DIpslA.p+hshLPLTpcNl+MFscAptshIPu.s+QFACcuCDhhWWRRVPQRKcVSRC++C+K+aDPVP.ss+MWGluEFpCspC++pF+Ga.uphsspSPCYGCppsl....YPh+ILPPR..Rs....ss.+opNpHSChAE.CYpRhEPaVPGspCsHP+SRptNphPKVlaPS.hHISoGSTluTCLSQGSL.E.-lspLIL-Dl	..........REKFHGKV.osc+AssLMR+FuSDHTGVGRSIVYsVKQcDGQ-LSNsLDAQDPP...........EDhKQ................................DpDIQAVA...TSLLPLTcsNLRMFQRA.Q-DLIPAVDRQFACSSC.DHVWWR..RVPQRKE.VSRCRKCRKRY-PVP.sDKMWGlAEFHCPKCRHNFR....Ga.AQMGosSPCYGCGaPV....aPTRILP.PRhDR-....scRRSsHTHSCS.AtDCYNRREPHVPGTSCAHPKSR+QNHLPKVLHPSssHISSGSTVATCLSQGuLlE.DLDsLILEDL............................	0	4	7	11
+14987	PF15136	UPF0449		Uncharacterised protein family UPF0449	Bateman A	agb	Jackhmmer:Q9UFG5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There is a conserved LPTRP sequence motif.	27.00	27.00	27.40	28.20	24.40	26.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.27	0.72	-3.78	9	48	2012-06-28 13:41:22	2012-06-28 14:41:22	1	2	39	0	29	50	0	89.30	47	80.26	NEW	uKKRsVLPTRPsPPoVEQILEDVcsA.usDPVFpsL....sss.s.pstss-uptEph.............Y.QSRpYlshNpRLppAtssLcp+p-pL+pAGEcLEp-lspV	.......KKRVlLPTRPsPPTVEQILEDV+uAsscDPVFThL..........cssss....t...p...tcss..-uttEph..........................................YQQS+sYlshNpRLppAt..s.Lpp+p-tLptsGppLcppl.p.................	0	5	8	16
+14988	PF15137	DUF4571		Domain of unknown function (DUF4571)	Bateman A	agb	Jackhmmer:Q9NYP8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrate. This family includes human protein C21orf62.	27.00	27.00	122.70	122.30	25.50	24.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.34	0.70	-4.91	6	34	2012-06-28 13:43:34	2012-06-28 14:43:34	1	1	27	0	20	29	0	213.10	65	94.93	NEW	MAPPSuHsLLLhuALGlFALssFTcGQ+NSTLIFTKENTIRNCSCSADIRDCDYSLANLMCSCKTVLPLAlEpTSYsG+LTIWFTDTSALGhLLNFTLVpDLKLSLCGTNTLPTEYLAICGLKRLRlsTEAKHPSsEQSLLIHsGGEucsREKsh.La+GWQTChYISFLDMALFNR-SuLKSYSIENluSlAssFPsFSYFcTFPl.oNKSYVVTFIY	........Ms.P.tasLLLhusLGlFALssFT+GQKNSTLIFTKE.NTIRNCSCSADI..RDCDYSLANLMCoCKTVLPhAl....E+TSYs..G+LTIWFTDTSsLGpLLNFTLVQDLKLSLCuTNTLPTEYLAICGL+RLRIssEA.KpsaPEQSLLIHSuu-o-sc-cshhLpKGWQsChYISFLDhALFNR-SuLKSYSIEN..VoSIANsFPsFSYF+oFPhsSNKSYVVTFIY.....	0	1	2	6
+14989	PF15138	Syncollin		Syncollin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VAF6	Family	This family has a role in zymogen granule exocytosis [1-2].	27.00	27.00	27.90	27.60	26.40	26.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.59	0.71	-4.17	6	27	2012-06-28 13:46:15	2012-06-28 14:46:15	1	1	23	0	17	28	2	110.00	61	83.22	NEW	ACPsPA-LKs-sGo+hCARhaE+SssYYDpsCGGu.LsVcPGsDhPYhPSsWsNpISSLVVupRCpLTVWSppGKpGssRKFSAGoh.+LcEY++GlFGsWscSIuuhYCpC	........ACPssA.DLKcsDGTRsCA+LY-KSDPYY-NCCsGApLSlEPGsDLPYLPSsWsNssSSLVVusRCELTVWSppGKuGKT+KFSAGoYPRLEEYR+GIFGsWuNuISulYC+C..	0	2	5	9
+14990	PF15139	DUF4572		Domain of unknown function (DUF4572)	Bateman A	agb	Jackhmmer:Q5VTT2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 220 amino acids in length.	27.00	27.00	36.50	35.80	25.50	24.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.43	0.71	-4.48	10	47	2012-06-28 13:47:15	2012-06-28 14:47:15	1	3	40	0	31	48	0	169.10	43	81.23	NEW	ERKGSLsL+Ss+hcYSsssLlpsWHpsREAcPKDYDlcshsstKpNLHpSTY+RlG..oDcsshslSpT+-thuQ.Vhlpc-apchh....++uhlchpo...hspshlE+Ds-tssouhcslhhc......psschcp.cYcTThppDYpsPYPYp....PssssP...sshslspRKh+spFsDL-up+RhGhspWpD-s.....tlht.pts+pclYcsp	........ERKGSLhLRSp+hpYSpssLs.sWHpsREA.PKsYDlcs.s...ts+pLppSTYpRlG..TDcsshhhSET+-phuQ.lhLpp-atchc....p+sLLs.-T...hspullERs.suhPtoGFGulhsR......HPP-hpKhph.TThppDYssPYsY......s.s.P...tsaSlsaRKCpSQFsDlss..+RhGhpoWpD-s.....tlhs.p.h+tpla...s........	0	10	11	19
+14991	PF15140	DUF4573		Domain of unknown function (DUF4573)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6P6B1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.	28.20	28.20	28.40	28.70	27.80	28.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.32	0.71	-4.66	10	82	2012-06-28 13:48:36	2012-06-28 14:48:36	1	15	39	0	62	80	12	137.60	21	37.03	NEW	AsDPstsTccTpPLcGlpEs-PPQPuGKDDs.sspppK+DlcAlTEspPLKGsAEsEPltstschpPLRssuEpDustAVcshEsPQsAuEMKPLpTAEpI.PLEuApEhpPpEAsGKscQsQlsEslPKEssSPEI..LEGSQ.lEsucppQLpEsLGcsEQsQsLEsVPKENto	....................................hps..s..t.ts.ps.tt.ps.t.s.tthcsspssopspPlpssspscPhts.sphpPlpsssphcshpslpss.csspsssp...hcPhpsspplpP....lpsspphpP.pshstsc.sp.hp.h.....................................................................................................	0	34	39	43
+14992	PF15141	DUF4574		Domain of unknown function (DUF4574)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6UW78	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between  and 86 amino acids in length.	27.00	27.00	29.40	28.70	26.00	25.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.81	0.72	-4.25	11	54	2012-06-28 13:51:19	2012-06-28 14:51:19	1	2	48	0	30	53	0	82.10	39	95.11	NEW	MsulRplLhusullGhG.GlGYulaslloPGEERKpEMLKshPEusPhRh-EscKpstLlhpsLcEAApTsENlAR....hhGu.t.......ppp	...............MtuhRhhh.slsllGhG.GlGhuLhsLloPGEcpKp-hLKphPppsPtpp-Est+pptLhhtsLQEAAsTpENlsh......h.s......stt.........	0	4	7	13
+14993	PF15142	INCA1		INCA1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VD86	Family	This family of proteins inhibits cyclin-dependent kinase activity [1-2].	27.00	27.00	37.60	36.90	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.32	0.71	-4.48	6	29	2012-06-28 13:54:22	2012-06-28 14:54:22	1	2	21	0	12	36	0	149.10	70	64.37	NEW	Phs+CSRVVSRSsPPuLPSQSLtLMPQ+YGDlFWENLSQRPoPTWhEEQYsPPLLRATGCSQPGLYPPEGLPPPEhLCRRKRRRPpLuGM.QQGsGuIPARVRAVTYHLEDLRRRQRIINELKKAQWGSSGAAsEPLsLsE-GCthPSTocY...DlEEERAsYPQEEs+hLTsGRsQLLW	Phh+CSRVVSRSsPspLPSQshR.MPQpYGDlFWcNLSQRsSssWhEEQaIPPhL..RATsCSp.uLa.P.EtLPPPEhLhRRK+RRPpLttM.QQG.GulPARVRAVTYHLEDLRRRQpIINELKKAQWGSSGAAsEPlslsE-GCthsSTscY...DLEEERAsYPQEEsphLTPGRsQLLW....	0	1	1	2
+14994	PF15143	DUF4575		Domain of unknown function (DUF4575)	Bateman A	pcc	Jackhmmer:Q6ZSN1	Family	This family of uncharacterised proteins is found in eukaryotes.	27.00	27.00	148.00	38.40	20.30	18.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.94	0.71	-4.42	4	8	2012-06-28 13:55:04	2012-06-28 14:55:04	1	1	1	0	2	14	0	73.10	36	95.59	NEW	spGGpcuhLSlPuShGVPPssAMGVLRARGspGAGSQS.PRsGs..P..........pctlhLS.PpLhGsAS..CDGuPKuQGGKRuWhSV.sSR...........................GVPPPsAhGVLtARGGRG.AGSpSLPRGsshP.hch	.............................................................ttctlhlS.shL.......s.Gs.+spGsptsh.ph.sStGlPPPsAhGVLtARGtcG.s.spp..............	0	2	2	2
+14995	PF15144	DUF4576		Domain of unknown function (DUF4576)	Bateman A	pcc	Jackhmmer:Q6UWT4	Family	This family of uncharacterised proteins is found in eukaryotes.	27.00	27.00	69.40	67.80	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.90	0.72	-4.36	5	24	2012-06-28 13:56:29	2012-06-28 14:56:29	1	1	19	0	13	22	0	83.00	70	99.75	NEW	MAVSVLRLTlVLGLLlLILTCQADDKPp-...KPD-KPDDSGKNPEP-FPKFLNLLGSEIIENAVEFILRSMTRSTGFMEaD...DKQGEHSoK	MAVSVLRLTlVLGLLlLILTCpADDpP.-.....+PD...cKPDDSuKsPcP-FPKFLsLLGTEIIENAVEFILRSMoRoouFhEht...sppsp+...........	0	1	1	1
+14996	PF15145	DUF4577		Domain of unknown function (DUF4577)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N8F7	Family	The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.	27.00	27.00	125.50	70.50	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.44	0.71	-4.23	3	33	2012-06-28 14:01:31	2012-06-28 15:01:31	1	2	26	0	19	25	0	118.50	71	98.86	NEW	MTHsSQDAGSRGhPE-RKLYVVDSINDLNKLSLCPAGSQHLFPLQEKIPDsGTsPGNGuRGLFFMGLIlVLIVSLALVSFVIFLIVQTGNKMDDVSRRLTAEGKDIDDLKKINSMIVKRLNQLDAEQN	............MsHSSQDsGSpGl..pEDtKLYVVDSINDLN.KLNLCPAGSQHL..FPLE-K..lPshG...TN.SG...NG..S....+SLFFVGLlIVLIVSLALV.FVIFLIlQTGNKMDDVSRRLsAEGKDIDDLKKINsMIVKRLN...QLDuEQN....	0	1	1	2
+14997	PF15146	FANCAA		Fanconi anemia-associated 	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VG06	Family	This family of proteins plays a role in the Fanconi anemia-associated DNA damage response [1].	27.00	27.00	27.30	47.50	20.90	26.70	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.57	0.70	-5.58	6	50	2012-06-28 14:04:41	2012-06-28 15:04:41	1	2	34	0	23	52	0	384.00	58	57.07	NEW	supAGQ+IK-LLSuIGsVSERVS.LKKAVDQ+N+ALssLNpsMNVSsALLSuppGs+P........IuCTlosoWSpL.hpDsLhATClLENSSuFSL-pGWTLCIQVLsSspAL-h-SusSAhTYThPVDpLsPGs+REVTLPLusucsGsLDLPVTlSCsLaYSLREllGsuLsss-shcs...tp.s..lLP-Q-GlCLPLscpTVDMLQCLRFsuhssspstus..s.huPspDPVcTFL+ospssssp.uGsu.S.p.....spYhPPSsASI+VSuELL+uAL+.soaSulsLssATLpWLLAENAAssllpupsloSlpGhAPDGs-V+Lhl+EVuloDLsPAGPIQAlEIQVESSSLAshCRhHHAllpRlQsLVhEQAApGSusPDLRhQYLpQhpsNHEoLL+ElQoLRD+..LCsED-hS.psuTup+LLplY+pLRsPSLlLL	..............s.tpsGp+IK-LLSGIGslSERVShLKKAVDQRN+ALssLNEsMNVSCAL.....L...SS.tpGs+P........ISCTsoTsWSRL.hpDsLhATClLENuSsaSL-pGWTLCIQVLsSSpAL-hDussSAhTYTlPVDpLuPGs+REVTLPLGPuEsGsLDLPV.TVSCsLaYSLREVlGuAh.ssS-u.-ss.h.-csPsshLP-Q-GlCLPLScpTVDMLQCLRFPuLA.....ss.pspuP..u.huPspDPVsTFLcos+t...P..uups..uGPu.SLR..........AcaLPP..SVASI+VSAELLRAA..Lc.D........ucSG..l..........s.....LCCATL.pWLLAENAAlDll.......+A.....p.....uLSSlQGlAPDGs-V+LlV+...E.....VAhTD..LC....P..AGPIQAVEIQVESSSLAshCRsHHAVltRhQs.MVsEQ.AAQGSSsPDLRlQYL.RQIauNHEsLLREVQoLRDR..LCTED-uS.SsATAp+LLQVY+QLRpPSLlLL.............	0	2	4	10
+14998	PF15147	DUF4578		Domain of unknown function (DUF4578)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96A22	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 137 amino acids in length.	27.00	27.00	27.50	72.50	25.20	24.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.80	0.71	-3.76	4	27	2012-06-28 14:06:32	2012-06-28 15:06:32	1	2	21	0	13	26	0	116.80	67	94.04	NEW	MGNRLCCGGSWSCPSTFQ+KKKhGSpsRhTLphQp......p.ht.NsoKsH-Tpu+TYEQVLpQPuSQcRS.puLpSEESsLHYADIQVhppspPRShpEVKHLpLENATEYATLRFPQATPRYDSKNGTLV	.....MGNRlCCGGSWSCPSTFQ+KKKTGSQsR.pTL+..Q............QQlpQNusKG+-TpGHTYEpVLpQ.sSQcRS..GLhpE-SsLHYADIQVCS+spsR...EVKHlpLENATEYATLRFPQATPRYDSKNGTLV......	0	1	1	2
+14999	PF15148	Apolipo_F		Apolipoprotein F	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q13790	Family	\N	27.00	27.00	27.30	31.90	21.40	26.80	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.38	0.71	-5.01	8	40	2012-06-28 14:12:08	2012-06-28 15:12:08	1	3	28	0	20	37	0	180.80	47	61.13	NEW	PloCQsLLspu..shsphAPLPcFLs.LALclsLEphGC.sEsa.LQLQLhchGGh-uTETLI+c......S++oscchulsslpuhLptLutpsssh+RscRSl.ssEsCcpEpc.sl+clAQL.......LPulshhhpLtTAlh.ATQpCoDcuhE+hc-suhcLshs..hp.AshshsspshlIupulpslh+ssVphlhpYaQ	.....................................PhoCQ.Lh.pu....sphAPLPcaLssLALcssLEcsGC.s-shsLQLQLh+.GGlsATpsLIpaLpt..LppuppspcpsSlcALsSALQLLAp...Ep.uspRspRSl.ssccC-sEcEQsVHsllpL.......LPuVGTaYNLGTALYYAoQNCssKA+ERGpDGAIDLGYDLLMsMsGhoGGPhGlsIoAuLKPAl+uGVppLIpYY..........................................................	0	1	3	4
+15000	PF15149	CATSPERB		Cation channel sperm-associated protein subunit beta protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H7T0	Family	The function of this family of transmembrane proteins, CATSPERB, has not, as yet, been determined. However, it is thought to play a role in sperm hyperactivation by associating with CATSPER1 [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 220 and 1107 amino acids in length.	27.00	27.00	182.50	52.80	25.30	21.70	hmmbuild  -o /dev/null HMM SEED	541	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.77	0.70	-6.31	5	43	2012-06-28 14:14:55	2012-06-28 15:14:55	1	3	29	0	29	39	1	462.60	52	59.02	NEW	+FcsIHhGKVIHSSKTGpAYIRcVhpHcT.PKGFhoSVIAElIEPFGlEss+ESsCLsSsLpIsauGNlaYpLoLpSQsspupFcuTDlEKTVlIPGYSSFLITcIlDspTAlAlATMPpolssNLsFLpuSWFLYNF..GptsGRoWpItoKPCNYWl.QQDphDuhSLNlVKYIDlGNolsFphKVIPssKuhpThEIP....LloVlVGNPsLLEVKApGaFDss-NYhLsIaluuKshppGSTSLAlIlWEuSocCaVoTllPTlKSSCSYLRoMHHIPu+aIP.EDWISGVHKDSQGFNMIKTLPINYRPPSsMGIuIPLTDNFYHADPS+PIPRNtFHpSKcTGKYKQCANVooREcCNCTccQKFSHAVAFSDC+EKVaRFKFPVTQYPVuLEIaNER-+IolEoPYLVTlTEVNMRcNWcLKHoVPENVKKMKsYLEPlL+oPVYNPLGLNLSIKGSELFHFRVSVV.PGVTFC-LpEEFQIYVDEsPLPFPGHsLIAVATAVVLGGLIFIAFlFQL+NIHPl+shp+.I+sNssphSoool	................................pFpslHhGKhIp.tpoGpAhIcKlhpHsh.spGFhSSVlsEhhcPFslEphp-SsCLsSSL.I.s..psGsh.Y+LoLp.p..sh..pu.FpsoDIEKTVVlPGYSSFLITpIlDspNALAlATMPppsssNhTF.csoWFLYNF..Gp+sGRpWpIhs+PCNYWh.Qpc..-o.SLNllKYIDLGsohshphKlI..p.s+.uhphhclP....LLpVhVGNPsLLE.VcscuhFD-oDSYlhpIsssSKhLppGSTSlAhlhWpASscChVTThVPTLKSSCSYL+oMHHlPu.......phIP.EDWlS..Gl..H+DSpGFNhIKTLPlNYRPPSNMGIAIPLTDNFYHADPSKPhPRNhF.hSKco.GKaK.QCANhooRcECNCTpcQKhSaAVAFSDC+EKVPRFKFPloQYPluLcIhs.Ec.splPlc.....sPYLVTlTEVN.RpNWcLK.H.slP-sl++hKpalEshltssVYNP.GLNLSIpGSELFHFRVoVl.sGVTFCsLlEEFQ.IYVDEsPLPFPGHsLIAluTAVVLGGLIFhAFh.FQlpsIHP.hpshpphhhpp........h................	0	6	7	12
+15001	PF15150	PMAIP1		Phorbol-12-myristate-13-acetate-induced	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q13794	Family	This family carries a BH3 domain between residues 23 and 40.	27.00	27.00	27.50	33.80	25.10	24.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.66	0.72	-4.20	3	17	2012-06-28 14:17:15	2012-06-28 15:17:15	1	2	13	4	9	25	0	50.50	67	80.49	NEW	MPGRKSRKSsQ..PuPTRV..PsDLEVECAIQLRRIGDKLNFRQKLLNLISKLFRLGT	......MPG+KARKsAQ...suPsRs...s-LE....VECAhQLRRhGDKLNFRQKLLNLIuKLFp.GT....	0	1	2	2
+15002	PF15151	RGCC		Response gene to complement 32 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H4X1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 130 amino acids in length. There is a conserved KLGDT sequence motif.	27.00	27.00	30.50	72.90	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.66	0.71	-3.68	7	49	2012-06-28 14:17:28	2012-06-28 15:17:28	1	2	36	0	28	52	0	124.20	66	97.60	NEW	M+Ssssp.tstshhh..................-.ts-Lu-lLpEF-sVlc-F.tSPhpppp.tY-cHLcphKRRoutSlSD.SGlsDSE.Su-o.htsShshS-EcLNososs..........TssKAKLGDTKELE-FIADLD+sLtp..M	.............................tstsshh..................ssstDLoDsLCEFDAVltDF.uSPhccRHF+Y-EHLE+MKRRSSASVSDu.SGFSDSE.SADSLYRNSFSFSDEKLNSPTsSoPuh..oPssoPpKAKLGDTKELEDFIADLD+TLAS.............	0	1	5	13
+15003	PF15152	Kisspeptin		Kisspeptin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q15726	Family	\N	27.00	27.00	29.80	29.20	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.84	0.72	-3.29	10	51	2012-06-28 14:20:42	2012-06-28 15:20:42	1	2	34	0	12	56	0	74.40	49	58.57	NEW	ssh.puLRss-p+Pss..Ap.ss+hou.s..scS.usGtphsuhshspSRlIPuPpGtlLVpREKDlSuYNWNSFGLRYG	....sWppu.pCsE+KPss..At.psRtsu.ssPsES.SuG.ppsuhs..uspSR.IPAPpGAlLVQREKDLSsYNWNSFGLRYG	0	1	2	5
+15004	PF15153	CYTL1		Cytokine-like protein 1	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9NRR1	Family	The function of this family of proteins, CYTL1, has not, as yet, been determined. However it is thought to be a secretory protein expressed in CD34+ haemopoietic cells [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 145 amino acids in length. There are two conserved sequence motifs: PPTCYSR and DDC.	27.00	27.00	75.40	27.90	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.56	0.71	-4.46	9	49	2012-06-28 14:21:46	2012-06-28 15:21:46	1	2	38	0	26	39	0	123.40	55	96.34	NEW	phsLhhLhsllu...hhhhup..ssPPTCYSRhLsLS+EIhsthpcLpsspsscsClchLPclalDlHNsClhoKLRDFlh......sspCtchs+lshLKc+lppLYsIhsphC+RDLVFhoDDCpALEsshsss.......phhs-.pp	....................h....hLLhLls...hs.hup..s...sPPTCYSRhLuLS+EIspsFppLQsoEPs-sCVchLP+LYLDIHNYCVLsKLRDFVA......SPpCh+hspVcsLK-KlRpLYTIMNSaCRRDLVFLoDDCsALEhPIsss.Ts.sD.............	0	1	3	9
+15006	PF15155	MRFAP1		MORF4 family-associated protein1	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9Y605	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 127 amino acids in length.	27.00	27.00	58.40	35.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-3.80	2	52	2012-06-28 14:25:25	2012-06-28 15:25:25	1	4	22	0	17	44	0	117.90	79	68.99	NEW	MRPlDhsEhtEPcE....EPtp.....L.Ps.pthREslAuLpRE+uRAahRsRpKLhEhpshL.tIKopVEApEcuAhs.h.pPtsts-tRsA+hstcA-cKAtEhA+MuchlVELhpRIttsEss	.....................MRPLDIsElsEPEEVEVLEPEEDFEQFLLPVINEMREDIASLoREHGRAYLRNRSKLWEMDNMLIQIKTQVEASEESALNHlQsPustA-tRsuchCEKAEEKAKEIAKMAEMLVELVRRIE+SESS..................	0	2	2	3
+15007	PF15156	CLN6		Ceroid-lipofuscinosis neuronal protein 6	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9NWW5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 190 and 310 amino acids in length.	27.00	27.00	127.10	46.60	24.00	23.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.82	0.70	-5.30	4	65	2012-06-28 14:27:27	2012-06-28 15:27:27	1	3	39	0	31	62	0	249.00	76	86.16	NEW	RtGStcscs.sspsu.FHhDLWhhFTLQNWlLDFGRPIsMIlhPL-WFPLNKPSsGDYFHMAYNIITPFLLLKLhERSP+TLPRSslYlSIITFVMGASIHLVGDSlNHRLlhSGYQhHLSVRENPIIKsLpPtTLIDSFELLYYYDEaLGHsMWYIPFFLILFlYFTGCFTplKAEp+MPsSAWlLLuPSulYYWYLVTEGQIFIlFIFTFFAMlAhVhHQKR+GhlLDSNGLFLhYSFulTLhLVulWVAaLWNDpVLRKKYPGVIYlPEPWAFYTLHlpsp	...............ps--.sspsu.FHLDLWFYFTLQNWVLDFGRPIAMllhPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSP+TLP..RShhYlSIITFlMGASIHLVGDSVNHRLlFSGYQpHLSVRENPIIKNLKPETLIDSFELLYYYDEY....LGHsMWYIPF...FLILFhYFSGCFTssK..uE.u.pMPssALLLluPSuLY..YW...........YLVTEGQIFILFIFTFFAMLALVLHQKRKtLaLDSNGLFLF.SFuLTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSS.p...	0	2	5	13
+15008	PF15157	IQ-like		IQ-like	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q1A5X6	Family	This family of proteins includes Human IQ domain-containing protein J (IQCJ).	27.00	27.00	27.90	36.20	26.30	22.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.32	0.72	-3.79	3	41	2012-06-28 14:29:59	2012-06-28 15:29:59	1	4	29	0	21	50	0	89.20	78	58.91	NEW	MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWRcYLpRQ-....sLGKRSPSPPSl...SSEKLSSSlSMNTFSDSSTP	.....EELKRLQNPLEQV......NDGKY.hENHQLA..MDsENNI.EKY.LNLQPLESKVKIIQRAWREYLQRQ-.....PLtKRSP.SPPSl...SS-KL.SSSVSMNTFSDSSTP	0	1	3	6
+15009	PF15158	DUF4579		Domain of unknown function (DUF4579)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q2WGJ8	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 192 and 239 amino acids in length. The human member of this family is C8orfK29.	25.00	25.00	25.90	25.60	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.14	0.71	-4.77	4	30	2012-06-28 14:36:54	2012-06-28 15:36:54	1	1	24	0	22	27	0	156.90	47	77.13	NEW	Gh.psERpluppLppNpFaPFtp..pPssFhLEYhhsoLaKull.FIlhhlhlshthlscVp+Q-..........TWsF.sYGlulGLWLhISShPpRRLVLNHsRGsYHFSIQGRTVCQGPhHLVYVRLALsSDA.tthFapLlLsGaplEshlLspho-Rh-ph-hLGRhIAR+lNlNYFDshs.......sShRpVVRHWs	......................p.ccpltp+LppN.FaPFhp....pPssFlLEYhhcsLaKGhLhFllsllh.lsht......lppspcQ-..........TWsF.saGlsVGLWL..l..lS.S.LP+RRLVLNHs+GhYHFSIpGRTVCQGPhHLVYVRLALsSD..u.GphaapLVLsGa+lEshsLspho-+h-phEhLGRpIARKLNlNYFDhhs.......sShRHllRHWs..........	0	6	6	10
+15010	PF15159	PIG-Y		Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q3MUY2	Family	This family of proteins represents subunit Y of the GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex. It may regulate activity of the complex by binding the catalytic subunit, PIG-A [1].	25.00	25.00	25.10	25.20	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.48	0.72	-3.76	10	56	2012-06-28 14:46:25	2012-06-28 15:46:25	1	2	51	0	36	65	1	68.90	33	66.62	NEW	hhGsLhllhGllhFluhhauAVlscllPsussshlSulp.DhYYsLLlPlTLPVhlssVYapWLShKlFKHA	.....................huhhhllhshl.hsshhYus...s..ls...c.............hPps.sssh...hshh....aYsLLlPlTlPVhlhhshasWluhKhF+Hs....	0	15	22	29
+15011	PF15160	SASRP1		Spermatogenesis-associated serine-rich protein 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q496A3	Family	Spermatogenesis-associated serine-rich protein 1 is a serine-rich protein differentially expressed during spermatogenesis [1].	27.00	27.00	31.60	36.20	25.90	26.40	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.72	0.70	-5.14	3	40	2012-06-28 14:52:34	2012-06-28 15:52:34	1	3	28	0	18	50	0	193.70	59	77.00	NEW	Ap+SDFLESKGCFANTTSS..GRSVSsSSSVETGLSVo-uPGLPRVhsYlDTAADLDpKoSSSHS........DHSSEsSLPEVQKDKYPEEFSLLKLQTKDGQRPEWTFYPRFSSNIHTYHVGKQCFFNGVFLGNRRSLSERTVDKCLGKKKYDIDPRNGIPKLTPGDNPYMaPEQSK-FaKAGSTLPPVNFSIVPYEKKFDTFIPLEPLPQIPNLPFWVKEKANsLKNEI+EVEELDNWQPAVPFLHuLLso	.....................................p..h.tSpts.Apthss..sppsS..SsstpG.plpts.u.s+s.s..s.sstLs.K.S.opS..................s+S.chSLPEl.KccaPcEFSLLp.QTpDGpRPEWTFYPRFSSNIHTYHVGKQCFFNGVFhGN++SluERTVDKshG+KK..YDIDPRNGIPK.LTPGDNPYMaPEQSKsFaKAGSTLPPVNFS.lsPYEKKaDTFIPLEPLPplPsLPFW.KEKANpLKNEIpEVEELDsWQsuhPhhp.hh..................	0	5	5	9
+15012	PF15161	Neuropep_like		Neuropeptide-like	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5BLP8	Family	This family contains putative neuropeptides [1].	27.00	27.00	29.90	58.60	25.90	19.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.05	0.72	-4.49	3	42	2012-06-28 14:58:50	2012-06-28 15:58:50	1	2	30	0	23	43	0	60.10	73	47.24	NEW	A-p-AGSAIPAESRPCVDCHAFEFMQRALQDLKKTAYNLDoRTEoLLLQAEKRALCDChPAs.L+	........t..uGoslPApSRPCVDCHAFE.FMQRALQDL+KTAaSLDuRTETLLLpAE+RA...LCsChPA.....t....................	0	1	3	10
+15013	PF15162	DUF4580		Domain of unknown function (DUF4580)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VVC0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 63 and 185 amino acids in length.	27.00	27.00	41.10	62.70	26.50	26.00	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.87	0.71	-4.88	6	41	2012-06-28 15:08:27	2012-06-28 16:08:27	1	1	33	0	25	38	0	157.00	62	91.64	NEW	sssp.ssslIIsuSLpsSElsphLps..psHKlRhScoltcsollFPLSGVAFLLlss.ph.h.......lsclppFlsh+pNuallLsuslas.pphthh..l..pRFLG.psLplLPVHssupslphMtTIAKhTsKPhhssIppRhpph+uhhlsp..usVWchLpplsLsp	........EphcWoTTlIISSSLcuaElATALEN..RSHKVRYSDSVEsGSIIFSLSGVAFLLMDscEChhSs...........EEhFLsKIEKFINIHpNSFLVLsAALHGPEEWcLMFRI.QQRFLG.sNLRILPVHNTsNAlsLMCTIAKoTSKPalDsICYRMIssKAYIIEQ..SPVW+TLQKIpLs.................................	0	4	6	9
+15014	PF15163	Meiosis_expr		Meiosis-expressed	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JSS6	Family	This family of proteins is essential for spermiogenesis [1].	27.00	27.00	50.90	50.80	20.40	17.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.78	0.72	-3.62	10	56	2012-06-28 15:09:45	2012-06-28 16:09:45	1	3	50	0	36	56	0	75.20	66	74.37	NEW	hoRAKcWScElEssYRFQpAGYRDElEYpplcpss.sERWPsp..GFVKKLQR.+DGsFhYaNKpREC-DK-lpKVKlYs	......hSRAK+WSEEIENLYRFQQAGYRDElEY+QVKQVuhVDRWPET..GYVKKLQR...RDNTFYYYNKpREC-DKEVHKVKlYt............	0	10	13	20
+15015	PF15164	WBS28		Williams-Beuren syndrome chromosomal region 28 protein homologue	Bateman A	pcc	Jackhmmer:Q6UE05	Family	WBS28 is an integral membrane family. These proteins have been identified as being linked to Williams-Beuren syndrome, OMIM:194050.  This family of proteins is found in eukaryotes, and are typically 266 amino acids in length.	27.00	27.00	27.10	62.60	19.60	26.80	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.07	0.70	-5.31	5	30	2012-06-28 15:40:57	2012-06-28 16:40:57	1	1	22	0	16	30	0	239.20	61	99.54	NEW	MEAlPsVRSSLhGILLlVlKLSVLLVQNRlHLYNFLLLKIsLFNHWLSGLAQEApGSss.Qs.HPPusIAACPLGRlLRAGLALlEVPsWLlLRGPRLsWAGhLGCARALGLAPKaLuAWEQLGLSAATWTDLFLSCLHuLMLAALLLLLLTWRLCQKAHCCuLGRLLSKALLtN+VVhcLLALLKRLYWWVEopTALTSWHLAYLITWTTCLASHLLQAAFEHTAQLAQAQEsEPQKu.SGsSSEoPLPEPsuPEAGPVLPEPGTPGE	....................MEAhP.VRSSLhGILLpVh+LSVLLlQNRsHLYNFLLLKIsLFNHWVSGLAQEApGSts.Qs.h.P.sh.suCPLGpALRAGLuLlpVPhWLlLpuPRLsWAuhLsssRslGLAh.hLuAWE.LGLSs.AsWpDLhLSCLHuLMLVALLLlLlTWRLCQKAHp.huLGhLh.SpAL..NplVhchLA.LRRLYWWVEohsALTSWHLAYLlTWTTCLASHLLQAAFEHTAQLAQ..AQEsEspcs.SGs...tssLsts.ssEuGslLsE.tTPtE........	0	1	1	1
+15016	PF15165	REC114-like		Meiotic recombination protein REC114-like	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z4M0	Family	REC114-like members are necessary for meiotic DNA double-strand break formation. It functions in conjunction with Mei4. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 259 amino acids in length.	27.00	27.00	49.40	27.60	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.66	0.70	-4.63	7	59	2012-06-28 15:59:42	2012-06-28 16:59:42	1	3	38	0	29	53	0	177.40	46	87.50	NEW	WPLpRYGRFh..sptcssssups.uttssPsWKVF-SNEESGpLlLTIVlSGHFFISQGQTLLEGFSLIsSpsWLK.IVRRhDCLLFsTshK....scSRhFRVQFuGs.ScEpALE+CCuCVQKL.upYVTVQssDshsppLp.u.Pu..psscSQsccp..phs.p.us..thppppsshshtsuhss..sphSh..........ppLAQolLssc.c.LPhsYcpSuWsAEELGPFLRLCLMDQNFPAFVE-VEKELKKL	........................................................................+lhtptcpt..h.hsll.uGahhl.pGpt.lLEG.FSLlsuppWLK..IsR+hDCLLFssphK....sc.SRhFRVQFuGp.S+EpALEcCsSCVQ+L.upYloVQhsDs..ppht.....Pu..tsstpp.pst...h..p.t..............tts..t..tphSh..........tpluQ.t..hLspt.t.LP.sYcp.....usassp-LtshLRLCLhDpsFPAFVEcVEcELKKl..............	0	5	9	14
+15018	PF15167	DUF4581		Domain of unknown function (DUF4581)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N3F0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically 131 amino acids in length.	27.00	27.00	39.80	38.80	20.70	16.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.71	0.71	-4.24	3	37	2012-06-28 16:04:52	2012-06-28 17:04:52	1	3	31	0	20	34	0	108.80	82	93.65	NEW	cpLADsAEKWCossPFDLIAsE-s.ERRhDFYA-PGlSFYVLCP-s..GssDpFHVWSESEDCLPFLQLAQDYISSCGKKTLHEILEKVFKSFRPLLGLPDVDDDTFEEYNADVEEEEPEADHQQMGVSQQ	..............ppLsDsA-KWCSssPF-LIhsE-s.ERRMDFYADPGVSFYVLCP-s..GCGDsFHVWSESEDCLPFLQLAQDYISSCGKKT.LHEVLEKVFKSFRPLLGLPDADDDAFEEYuADVEEEEPEADH.QMGVSQQ.........	0	1	3	9
+15019	PF15168	TRIQK		Triple QxxK/R motif-containing protein family	Eberhardt RY, Coggill P, Hetherington K	rdf	Jackhmmer:Q629K1	Family	TRIQK member-proteins share a characteristic triple repeat of the sequence QXXK/R, as well as a hydrophobic C-terminal region. Xenopus and mouse triqk genes are broadly expressed throughout embryogenesis, and mtriqk is also generally expressed in mouse adult tissues. TRIQK proteins are localized to the endoplasmic reticulum membrane.  This family is found in eukaryotes and members are typically between and 86 amino acids in length.	27.00	27.00	48.80	48.80	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.66	0.72	-4.06	6	38	2012-06-28 17:39:22	2012-06-28 18:39:22	1	1	32	0	21	31	0	75.90	70	94.04	NEW	MGR........KDASos+hPVDQYRKQIGK.QDYKKTKPlLRAT+LKAEAKKoAIGIKElhLh...lsAILsLLhAaYAFFaLplSsshsl-	.........MGR........KDAuThKLPVDQYRKQIGK.QDYKKTKPILRATKLKAEAKKTAIGI.KEVuLV...LAAILsLLLAFYAFFYLpLos-lD.s................	0	4	6	9
+15020	PF15169	DUF4564		Domain of unknown function (DUF4564)	Bateman A	agb	Jackhmmer:Q9BQA9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes the human protein C17orf62.	27.00	27.00	32.10	31.30	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.00	0.71	-4.56	8	54	2012-06-29 07:58:34	2012-06-29 08:58:34	1	2	47	0	41	65	0	171.20	52	93.47	NEW	M.YMplEc+TushLHLcRuPuIRSWSLhVGIuSlGLAAAYYSoDohLW....KlFYlsGClFVALQNlE-WEEAlFsKpKsclpLcohsLYchlLTh.+tGpEp..VVl-LcclRDlsVQEE+lRYhGcGYlll...LRassGhSaPLTQoushGsRSDVEAlAshls+FLphcpltup...phspopssDsDpspDpu	...................................M.YMpVEp+TuohLHL.KRuPGIRSWSLLVGIhSlGLAAAYYSuDSlhW....KLFYVsGCLFVAlQNLEDWEEAlFsKssGcVhLKTFSLY++lLTL.+sGH-p..VVl.Lp-lpDVsVEEE+VRYFGKGYhVV...LRhuT..GF.SaPLTQSAshGp..RSDVEAlAcLIssFLcLcplps.t....p.spopsu-sst....st.................................	0	10	14	24
+15021	PF15170	CaM-KIIN		Calcium/calmodulin-dependent protein kinase II inhibitor	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z7J9	Family	CaM-KIIN is the inhibitor of Calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII plays a central part in long-term potentiation, which underlies some forms of learning and memory. CaM-KIIN is a natural, specific inhibitor of CaMKII [1]. This family is found in eukaryotes.	27.00	27.00	30.90	30.50	22.50	21.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.52	0.72	-3.99	5	59	2012-06-29 10:35:08	2012-06-29 11:35:08	1	1	33	5	31	45	0	72.70	70	98.10	NEW	MSElLPYSE-KMusYGsDu-VGQlSFSCRLQDTsuFFAGuQuKRPPKLGQIGRAKRVVIEDDRIDDVLKGMoDKuPPGV	...........MSElLPYu--KhutaGs-s-suphSFSCRLQDTNsFFuusQuKRPPKLGQIGRuKRVVIEDDRID.D.VLKsMs-KsPsGV.......................	0	2	6	14
+15022	PF15171	Spexin		Neuropeptide secretory protein family, NPQ, spexin	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9BT56	Family	Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors [1]. Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance [2].	27.00	27.00	40.40	39.90	20.80	18.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-9.99	0.72	-3.99	3	34	2012-06-29 10:43:10	2012-06-29 11:43:10	1	3	27	0	20	24	0	79.00	66	73.58	NEW	APQRLFERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLuDRPPLERRSPNop.LTLPEAAALLLASLpKuQEsE-ENhD+ocaLEDsLhNW	.APQthhERRNWTPQAMLYLKGAQGRRFISDQSRRKDLuDRs....PERRSPNsphLolsEAAAlLLASLQKspEstEcNhDp.sphL.DpLhsh....................	0	1	2	5
+15023	PF15172	Prolactin_RP		Prolactin-releasing peptide	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:P81277	Family	\N	27.00	27.00	32.60	32.20	23.90	18.30	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.46	0.72	-4.74	8	46	2012-06-29 10:46:53	2012-06-29 11:46:53	1	1	34	0	17	37	0	46.20	57	48.59	NEW	SRuap......Hsh-hRoP-IDPhWYsGRGlRPlGRFG+Rputhtcuupsph+	.........Rsap......HShEhRoPDIsPuWYsGRGIRPVGRFGRR+ushtcsspst..........	0	1	3	6
+15024	PF15173	FAM180		FAM180 family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6P0A1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 182 amino acids in length. There are two conserved sequence motifs: ELAS and DFE. The function of this family is unknown.	27.00	27.00	34.90	34.60	22.40	18.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.68	0.71	-4.39	7	69	2012-06-29 10:48:52	2012-06-29 11:48:52	1	1	38	0	40	57	0	133.30	48	77.10	NEW	LaPuAhRsKRu.uuhlNPs.....hQpolE-VpLLaElLLAGlphsst.tthplpDtELASLR+spcLcsICpcllP+pLs-I+RLoupLusphG..sL+hEDFERTlLThVYTA.plspu.pspQR-hWupohlpLapAlKtDL	..........LaPuApRsKRuuu.PlNPs........LQpShE-VELLaEhLLAtL-lsss.hplpIcDEELASLR+Apch+hlCpclIPKsls-I+RLsupLush.u..sL+p-DFERTlLThsYsAYRhshu.pucQ+-hWApuhspLaQAl+aDL..................................	0	2	3	11
+15025	PF15174	PRNT		Prion-related protein testis-specific	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86SH4	Family	PRNT is a family of prion-related proteins expressed in the testis [1,2].  This family of proteins is found in eukaryotes. Proteins in this family are typically between 52 and 94 amino acids in length.	27.00	27.00	37.50	87.20	17.80	16.80	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.66	0.72	-4.31	3	15	2012-06-29 10:52:38	2012-06-29 11:52:38	1	1	15	0	1	13	0	49.00	70	73.43	NEW	NTsLhHSAWPLShLHQTVSTLKAVAVTHSLWHLQIPVDCQACNRKSKKIYC	NhPILLSHYPLP...QQTETWKAAsAllSLWaLQSPGDGQACDRESVKIYC	0	1	1	1
+15026	PF15175	SPATA24		Spermatogenesis-associated protein 24	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86W54	Family	This family of proteins bind to DNA and to TBP (TATA box binding protein), TATA-binding protein (TBP)-related protein 2 (TRF2) and several polycomb factors. It is likely to function as a transcription regulator [1-2].	27.00	27.00	52.40	29.70	22.10	26.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.15	0.71	-4.52	6	45	2012-06-29 10:53:44	2012-06-29 11:53:44	1	1	33	0	24	40	0	148.00	65	69.24	NEW	uKEEFpAlcKcL.-EKstHAKTKsLLAKEpEKLQFALGEV-VLSKQLE+EKhAFEKAhusVKsKAhQESuc+DQLloKCsEhp...pcll....+QEDlLNuKE.cI+-LpphlupQKpsh..............H+sphS-hc..........IQppQ-tYh..sp.h.scs+hpputphsGp	.....................SKEEFQAVEKKLV.EEKAAHAKTKlLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKS+VLQESSKKDQLITKCNEIE...SHII....KQEDILNGKENEIKELQQVISQQKQIF....................psphSshR..........IpK.Qtphh..ApslstKpKhssuh.....s..............................	0	7	8	10
+15027	PF15176	LRR19-TM		Leucine-rich repeat family 19 TM domain	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IVY1	Domain	LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity [1]. This family of proteins is found in eukaryotes.	27.00	27.00	45.60	44.30	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.58	0.72	-4.33	9	67	2012-06-29 10:54:56	2012-06-29 11:54:56	1	8	31	0	41	50	0	103.90	48	43.54	NEW	souSssuPusuoG...uRuWPlLVGVVluAlllSLLIALAAKCpLC++ahsSYpH+PLsEs.....................GpuspPsVs.....csE...............DDDGFIEDNYIQPutst.Es	..........s.outsshstsups....u+uWshLVGVVlsslshSLLIhlAhKC.lhhpahhSYpH+.LpEp..........................GhsspPpss.....psc...............DDDGFIEDpYIpstphp........	0	2	6	12
+15028	PF15177	IL28A		Interleukin-28A	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IZJ0	Family	The protein family, Interleukin-28A, plays an important role in modulating the immune system. This protein family is induced by viral infection and interacts with a class II receptor [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 195 amino acids in length.	27.00	27.00	30.10	30.10	25.00	19.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.85	0.71	-4.73	10	96	2012-06-29 10:56:35	2012-06-29 11:56:35	1	3	32	6	51	94	0	145.40	55	79.55	NEW	ssuKGCHluQFKSLSPQELpAFKKAKDAlEESL.LKsWsCSSRLFPRshDL+QLQVhERPVALEAELALTLKVLEshADo..uLuslLDQPLHTL+HIHSpLQA..ClpsQPTAGP.RP+GRL+HWLHRLQEAsKKEStGCLEASVTFNLFRLLTRDLKCVASGD	........pt+uCclupFKSLSPp.ELpAFK+A+DAhE.-SLh.KshpCpS+lFPRshDL+pLQ......V.hERPlALEAELsLTLKVL.pshscs..uLsclL-QP....L+TL+HIpSpLpA..ClpsQPTAuP....+P.pGR.L++WLHRL.....pEA..cKESsGCL.EASVhFNLFRLLTRDL+CVAsGD.......	0	3	3	14
+15029	PF15178	TOM_sub5		Mitochondrial import receptor subunit TOM5 homolog	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N4H5	Family	This is a family of transmembrane proteins thought to form part of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex) [1]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	30.20	30.10	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.55	0.72	-4.27	4	39	2012-06-29 10:58:52	2012-06-29 11:58:52	1	1	25	0	14	50	0	46.20	79	78.66	NEW	MF+lEGLuPKhDPEEMK+KMRpDVISSVRNFLIYVALLRlTPYILKKLDSI	..........MFRIEGLuPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPallp.............	0	3	4	6
+15030	PF15179	Myc_target_1		Myc target protein 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N699	Family	This family of proteins is regulated by the c-Myc oncoprotein. It regulates the expression of several other c-Myc target genes [1].	27.00	27.00	27.70	27.20	25.10	24.80	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.33	0.71	-4.72	7	50	2012-06-29 10:59:41	2012-06-29 11:59:41	1	1	38	0	29	42	0	176.40	62	89.94	NEW	MApNsTshh.phhcsF.apsllLAFslSMllGLllGulIahllThhS.RRRASApIoptsspppppp...pS.s.hts+hGaYR.souh-R+Ss.SL..AuLohpRQsSlE.s...sshsRKsSFcuSTF+Phhpss.hs..s-psuQh...........sshssssssssshs.sss..pRssFahussuLRshhsoQTPPPAYDSlI+AF.E..o	..................MApNsTslh.sWscsF.WEDLIhSFTVSMAIG.LVlGGhIWALhsCLS.RRR.A.SA..sISQWSsSRRoR.......SSasHuLNRTGFYR.HSGCERRSNLSL...ASLTFQRQASL.EQA...NSFPRKSSFRASTFHPFLQCPPLP..VET-SQL...........hTLPuSs...sossl..sosHSLuRPDaaWSsNSLRhuhST.sPPPAYESIIKAFPD...S.....................	0	1	5	13
+15031	PF15180	NPBW		Neuropeptides B and W	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N729	Family	The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes [1,2].	27.00	27.00	31.90	31.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.68	0.71	-4.47	8	57	2012-06-29 11:40:11	2012-06-29 12:40:11	1	3	30	0	29	48	0	111.70	41	85.80	NEW	sphshlslAlsLLlus.PutAWYKpsAGPuYYSVGRASGLLSGlRRSPYsRRS-scuuAts.ut.............suspsp.pssLRShslCVpDlsPNLpSCEhLsDGsGsa............QCKA-VFLSLcShDChsA	........t...shhslhLhLLlhs.PuhAWYKpsAuPpYYoVGRAuGLLSGlRRSPYh+Rupspsssts.u...............tsshp.pssl+ohs.........lhlpshs.pL.pschh.sstGhh............ptps-shLoLcuhDt.t........................................	0	2	4	13
+15032	PF15181	SMRP1		Spermatid-specific manchette-related protein 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NCR6	Family	This family of proteins, SMRP1, is thought to have a role in spermatogenesis and may be involved in differentiation or function of ciliated cells [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 260 amino acids in length.	27.00	27.00	85.50	85.50	25.50	25.20	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.92	0.70	-4.99	5	38	2012-06-29 11:41:30	2012-06-29 12:41:30	1	2	28	0	21	48	0	226.30	62	93.33	NEW	MFLFSRKTKTPISTYSDSYRAPTSIKE.VYKDPPLWAWEANKFVTPGLTpTMcRHVDPEAL.QKMsKCAsQDYTYKuSISGHPYLPEKYWLSP-EtDKCsPsYLss.......D+YNTWRTuPYSsh.WNKYTTYLPRLPKEsGMEThVRGMPLEYPPKPERLNAYEREVVVNMLNSLSRNpsLPQIsPRCGCVDPLPGRLPFQGYESsCSGRHYCLR..GMDYhsoGsPsT-RRLRPLCscpPThpolLpsssRsulsC.........YsSPslIlPhSEP	..MFLFSRKTKTPISTYoDSYRAPTSIKE.VYKDPPLhAWEANKFlT....PGLTpTM.cRH.VDPEAL.QKMsKCAsQDYoY+uSIsGHPYLPEKYWLSp-E.....t......DK.......CsPsYLsu.......DRYNTWRhuPYNsosWNKYTThLPRLPKEAGM.ETsVRGMPL-hPPKPERLNAY.......EREVhVNMLNSLSRNQ.LPpIsPcCGCscsLPGRLPFpGY-SsCSGRHYCLR..GMDYhssGsPss-R.+Lpshs.pp.T.pss.......tRsshpC.........Ys.Pslhhsh.p...............................................	0	2	2	6
+15033	PF15182	OTOS		Otospiralin	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NHW6	Family	This family of proteins, Otospiralin, has a role in maintaining the neurosensory epithelium of the inner ear [1,2]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 90 amino acids in length.	27.00	27.00	60.30	60.10	22.10	20.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.42	0.72	-4.31	4	41	2012-06-29 11:45:03	2012-06-29 12:45:03	1	1	35	0	27	29	0	66.30	70	77.66	NEW	A+Pl.tEtsPYtEsPAhPYWPaSTSDFWNYVpaFpolGAYsQlpDhARTFFAHaPLGsTLGacVs.p-E	......A+Pl.EEuDPYsEsPAMPYWPFSTSDFWNYVpYFQoLGAYsQIpDMARTFFAHFPLGoTLGaHVPYpE-....	0	1	3	11
+15035	PF15183	MRAP		Melanocortin-2 receptor accessory protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8TCY5	Family	This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.	27.00	27.00	54.50	50.30	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.20	0.72	-4.38	6	76	2012-06-29 12:32:18	2012-06-29 13:32:18	1	2	40	0	41	79	0	84.20	54	53.03	NEW	MANpTNuSs.aaSYEYYLDYlDLlPVDE+KLKAsKYSIVIAFWVSLAsFVhhLFLILLYMSWSGSP.Qs..Rsusppa.hCsWs+uhsLPLCl	...........pusss..Ss.h..apYEYY.-h..h.PVs.ctLKAHKYSIVIuFWVuLAsFVlFhFhlLhhhohoGuP.Q....csut++aphssaspshsh.Lp.................	0	2	5	14
+15036	PF15184	TOMM6		Mitochondrial import receptor subunit TOM6 homolog	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96B49	Family	TOMM6 forms part of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex) [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 74 amino acids in length.	27.00	27.00	36.20	49.70	24.20	18.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.22	0.72	-4.64	3	36	2012-06-29 12:33:59	2012-06-29 13:33:59	1	1	28	0	16	40	0	70.80	80	98.87	NEW	MSuSsVKs.uAGSuG........VuDWlRusCRFATDRNDFRRNLLVNLGLFAAGVWVARNLSDFDLMSPQPlT	..............MASSGVsVoAAGSANEsPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV........	0	1	1	2
+15037	PF15185	BMF		Bcl-2-modifying factor, apoptosis	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96LC9	Family	BMF is thought to play a role in inducing apoptosis.  It is thought to bind to Bcl-2 proteins [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.	27.00	27.00	27.30	27.00	17.80	17.20	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.50	0.70	-5.05	4	51	2012-06-29 12:35:41	2012-06-29 13:35:41	1	2	32	1	21	64	0	159.20	56	91.31	NEW	-hPpCsEpshpphct..........................ccDsapu-sup.............sspsushhAuulhspspphDs..tchph.PlophhGsshRshptp-+ATQoLu.usuup.............ulhhsCGlptpP+tLFaGNAGaRlHh.PAsFthu.shhEpspptQ....................p.thpsEVQIuRKLppIuDQFpp.HlQ....pHppN.sthhh.lhhFhc.Lh.p.t...pssG.p	.............................................................................CVE........L.........................EDDVFQPEDGE............PusQPGuhLSADLFAQS..LDCPLSRLQLFPLTHCCGPGLRPsuQEDKATQTLSPASPSQ.............GVMLPCGVTEEPQRLFYGNA.GYRL.l.PAuFsss.shtEpP.EuQ......................pHRsEVQIARKLQCIADQFHRLHhQ.......pHQQNpspsWWQlhLFLpNLALNtctNRpssG...........................	0	1	3	7
+15038	PF15186	TEX13		Testis-expressed sequence 13 protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BXU2	Family	The function of this family of proteins has not, as yet, been determined. However, members are thought to be encoded for by spermatogonially-expressed, germ-cell-specific genes [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 177 and 384 amino acids in length. There are two conserved sequence motifs: FIN and LAL.	27.00	27.00	82.70	79.20	21.80	20.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.74	0.71	-4.64	12	77	2012-06-29 12:37:16	2012-06-29 13:37:16	1	2	22	0	44	57	0	147.00	52	44.30	NEW	cs-DsoSGF+HucVlhFINEchu+pu+GPEFYL-NlSLSWEEVEDKL+sIL-DopVPpplKcACsWuoLALGVRFAtRQsQLQu+RVpWLpDhupLH+SAAhuLAS-LpcLpcQpEhEppEAAhQLp.spspLtEsp+ERDlhRh+lhpsEL	.....s-DPuSGFRHucVltFINEchspps+GPEFYlpNhShSWcEVEDKLRuILpDopVPppsKcACsWuuLALGVRhApRQtpLQs+RVphLp-hsc.H+oAu.ALAS-LpcLppppEh-ppEAAhQLphspssLtcspcERDhLph+Lhph..................	0	2	2	4
+15039	PF15187	Augurin		Oesophageal cancer-related gene 4	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H1Z8	Family	Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterised by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation [1]. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF [2]. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.	27.00	27.00	81.90	81.80	24.00	23.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.58	0.71	-4.22	9	52	2012-06-29 12:39:44	2012-06-29 13:39:44	1	1	39	0	31	47	0	112.90	68	82.25	NEW	spLc+lLpKR-sst...sPu+ssVAVstuKAKEFLusL+RsKRslWDRSRPDVQQWIQQFMYMGFDEs+LEsDLSYWMDpuRuuDQG....RQHHYDENAsIGPRsP.....poaRHGAsVNYD.Y	....NKL+hhLQKREAs....sPoKspVAV..sEsKAKEFLuSL+RpKRQLWDRoRP-VQQWYQQFLYMGFDEAKFEDDloYWhN+sRsGc-YY.sYaQ+HYDEDuAIGPRsP.....toFRHGAuVNY.DDY	0	1	6	13
+15040	PF15188	CCDC-167		Coiled-coil domain-containing protein 167	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9P0B6	Family	The function of this family of coiled-coil domains, has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 103 amino acids in length.	27.00	27.00	28.20	27.60	26.50	25.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.76	0.72	-4.04	11	60	2012-06-29 12:41:00	2012-06-29 13:41:00	1	2	48	0	40	60	0	83.00	45	80.04	NEW	hSVs+EIDphEEclspC+ppl-plEp+L+cpcLocEpRpslE.......cEhstlpppLps.EccLptL++......ENpKshhlusAlhhlphLlYs	............uVs.EIDGLEEKLupCR+cLEsVss+L+ptELSsEsRcuLE.....................cE+ssLhs+hpshE+ELphLRp......ENRKshhLusulhllhsLlY......	0	8	11	21
+15041	PF15189	DUF4582		Domain of unknown function (DUF4582)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A2RUB1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 126 and 788 amino acids in length. In humans, it is encoded for on the chromosomal position, C17orf104.	27.00	27.00	34.80	28.40	19.60	24.50	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-10.69	0.71	-5.03	10	105	2012-06-29 12:45:26	2012-06-29 13:45:26	1	4	56	0	70	98	0	140.20	36	32.71	NEW	pRousus-LHhpLEEChEQaRpLEKERKKTEA-LARpshGK+VS.SoNNhPlPRLsssPSRVDRLIVD.hREHAR..VlTLLuKMEpLRusslssslapALcpaLEAI+hlQspRpsEhhNhlpp.R...tth..h+ap-D+DlhsLAuAlpplspAsR+ARTAhWCuL.hTLshssssp	.........p.G.hpplph+h.psh.Q.pth-.cE.c.pKpp.uLupNh.tctlp.SpsphslsRh.sus....sSRV.s.Rhhlsphpp.up..lhs.Lt+....cp...LtSs.sh.hphopshs+pl.slh.s.shhpp-hh...................................................................s..........................	0	16	21	38
+15042	PF15190	DUF4583		Domain of unknown function (DUF4583)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N6I4	Family	This family of proteins, also known as UPF0694, is found in eukaryotes. Proteins in this family are around 135 amino acids in length. In humans, it is found on the chromosomal position, C14orf109.	27.00	27.00	33.10	32.20	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.86	0.71	-4.50	3	53	2012-06-29 12:59:36	2012-06-29 13:59:36	1	3	42	0	32	56	0	123.10	77	85.96	NEW	MNFRQRMGWIGVGLYLLASsAAsYYVFEIS-TYNRLALEHIQp...........suppsPSuTTWppTLKTRLLuLPFWhWslIFLlPYLQVFLFLYSCTRADPKTVGYCIlPICLAVlCNRHQuFsKAS...NQISRLQLI	.MNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQ...........HPEEPhEGTTWTHSLKARLLSLPFWLWTlIFLlPYLQMFLFLYSCTRADPK.TVGYCIIPICLAVICNRHQAFVKAS...NQISRLQLI............................	0	7	9	16
+15043	PF15191	Synaptonemal_3		Synaptonemal complex central element protein 3	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A1L190	Family	\N	27.00	27.00	67.30	67.20	23.10	19.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.30	0.72	-4.25	2	24	2012-06-29 13:00:14	2012-06-29 14:00:14	1	1	22	0	14	28	0	84.90	78	98.03	NEW	Mssu.s-.p.h-sh.p...pLNpcLEKhhEpMEclSVphohMsYDMVVhRTsPsLAESh+pLEstF.pCK.........pEhcpp.t-..p.o.p	...MADuDPsERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCK.........EEMEKNWQELLpETKp........	0	1	3	3
+15044	PF15192	TMEM213		TMEM213 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A2RRL7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 154 amino acids in length. The function of this family is unknown.	27.00	27.00	99.80	99.70	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.07	0.72	-3.97	3	30	2012-06-29 13:01:11	2012-06-29 14:01:11	1	1	27	0	20	29	0	78.70	73	69.80	NEW	uAusSs.SssouuTsH+PcsGTLSs..Cs-VDFCPQAARCC+TGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPKDLQA	.............t..tAou.SssSolTsHHPDs.GTLEp..C.NVDFCPQAA+CC+sGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPKDLpA.	0	1	1	4
+15045	PF15193	FAM24		FAM24 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NFZ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 101 amino acids in length. There are two conserved sequence motifs: FDLRT and CLY. The function of this family is unknown.	27.00	27.00	37.60	37.60	17.10	15.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.64	0.72	-3.79	6	38	2012-06-29 13:01:55	2012-06-29 14:01:55	1	2	16	0	19	39	0	68.70	51	71.62	NEW	LY.KIuKALKsA+.....-sEssh....DPsKssp-phIp.............AKsIssEoCtsLQCC-sCuhatsssSLPPChCshNEGL	...LYhKlu+ALKAAK.....-s-ssA....NPsKshh.sKs..p.............AcohssESCPuLQCC-sC+MYAsaDuLPPChCDlNEGL.	0	2	2	2
+15046	PF15194	TMEM191C		TMEM191C family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NGB0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 302 amino acids in length. There are two conserved sequence motifs: QDC and RLF. The function of this family is unknown.	27.00	27.00	36.00	36.00	23.50	22.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.45	0.71	-4.23	3	23	2012-06-29 13:02:45	2012-06-29 14:02:45	1	2	17	0	11	31	0	105.90	59	74.86	NEW	MEAAAALDAoRSGpEPCDSQLRRVQDCoGSLMEEVARADCEKRLFGGAGAGuIRLWALGALQTLLLLPLGFLuLPLLYLVLlcPsAlusGLtSLoS-AsLRRLRYTLSPLLELRARGLLPA	.....................................................MEAAAtLDAhpuGpEPhDup.RtVQ.sstSLMEEVARADp.EhRLFGG.ssA.............hul.RhhsLuALQsLLhLPLhFLsLsLLahsLhcPsAlpthL.tpLsS-sshRRLRYTLSPLLELRApGLLPs.............	0	1	1	1
+15047	PF15195	TMEM210		TMEM210 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NLX4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 149 amino acids in length. The function of this family is unknown.	27.00	27.00	27.00	60.70	26.90	18.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.62	0.71	-3.96	3	17	2012-06-29 13:03:35	2012-06-29 14:03:35	1	1	15	0	8	14	0	105.80	72	79.88	NEW	TYCECSLGLSREALIALLVVLAGVSASCFCALVIVAIGVhRAKGETCPRHs-NRLVGsYGVQEDRMDLHTVaVESHLMDPDLEVSMMPPLE-QGLhsMThPl-P.sP....PPPPPLsPp	TYCECSLGLSREALIALLVVLAGlSASCFCALVIVAlGVlRAKGETC.Ptth-sRLVtpFGVQEDpMDLHsVaVESpLMDsDLEVShMPPLE-puLhsIsM-sssEEP....PPPPP..P............	0	1	1	1
+15048	PF15196	Harakiri		Activator of apoptosis harakiri	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O00198	Family	\N	27.00	27.00	126.40	126.10	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.41	0.72	-3.74	2	15	2012-06-29 13:04:25	2012-06-29 14:04:25	1	1	14	2	9	12	0	91.20	88	100.00	NEW	MCPCPhHRGRGPPAVCuCusuR.GLR.uAAQlTAhRLpALGDELHpRsM.RRRARsRc.PhPuhLPsh...WPWLCAAAQVAALAAWLLGRRsh	MCPCPLHRGRGPPAVCACSAGRLGLRSS.AAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGA.......LPTY...WPWLCAAAQVAALAAWLLGRRNL	0	1	1	1
+15049	PF15197	Leukemia_assc_2		Leukemia-associated protein 2	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O43262	Family	\N	27.00	27.00	53.80	89.80	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.77	0.72	-4.30	6	9	2012-06-29 13:05:10	2012-06-29 14:05:10	1	1	7	0	1	6	0	53.30	76	83.92	NEW	MKMSFERCTARNKMFVNSAFTK.VDNYCTFL.KKhhhKshF.lphhpKtKK.DLNF	MKMSFERCTARNKMFVNSAFTK.VDNYCTFL.cKhhFKshF.lphhpKtKK.DLNF..	0	1	1	1
+15050	PF15198	Dexa_ind		Dexamethasone-induced	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95424	Family	\N	27.00	27.00	138.80	138.60	22.60	16.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.43	0.72	-4.07	2	27	2012-06-29 13:05:54	2012-06-29 14:05:54	1	1	27	0	19	18	0	90.90	90	99.92	NEW	Mssu.VhhpLDultsLls......LP.MaYlGLFFVNVLILYYAFLMEYIVLNVGlVFLPEDMDQALVDLGVLSDPuSh.YDsDoELDVF-GYLE	..M.GARVAAHLDuLGPLVsaVPPPLLPSMFYVGLFFVNVLILYYAFLMEYIVLNVGLVFLPEDMDQALVDLGVLSDPGSGLYDADSELDVFDGYLE	0	1	3	7
+15051	PF15199	DAOA		D-amino acid oxidase activator	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P59103	Family	\N	27.00	27.00	53.50	52.80	18.70	16.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.85	0.72	-3.35	2	15	2012-06-29 13:06:51	2012-06-29 14:06:51	1	1	6	0	2	10	0	67.10	71	58.39	NEW	MAQRHLQRSLCPWVSYLPQPYAE......H.uKVhhstNhc...................Cpapp.pp..ssHh..ssTc.t	........MAQRHLQRSLCPWVSYLPQPYAELEEVSSHVGKVFMARNYE.....ASKDRRQPLERMWTCNYNQQKDQSCNHKEITSTKAE.	0	2	2	2
+15052	PF15200	KRTDAP		Keratinocyte differentiation-associated	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P60985	Family	\N	27.00	27.00	76.00	68.30	25.50	18.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.76	0.72	-4.21	3	29	2012-06-29 13:07:40	2012-06-29 14:07:40	1	1	23	0	16	20	0	76.80	71	78.34	NEW	AALGoPp...EDTThuNYPoGTEGLNuEFLNFcKLQSAFKSD-FLNWHVLTDMFK+ALPFINWDFFPKVKGLRSAsPDSQ	AuLGusE....EETTIsNYAutPEAFNspFLNlDKLRSAFKs-EFLNWHALFESIK+KLPFLNWDAFPKLKGLRSATPDAQ.	0	1	1	2
+15053	PF15201	Rod_cone_degen		Progressive rod-cone degeneration	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q00LT1	Family	This family of proteins is involved in vision [1].	27.00	27.00	29.70	29.70	18.40	17.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.61	0.72	-4.12	5	14	2012-06-29 13:13:08	2012-06-29 14:13:08	1	1	12	0	8	16	0	49.10	76	96.08	NEW	MCTTLFLLSTLAMLWRRRFANRVQPEPScVDGAVVGSuSETDLQSSGRE+..uPVK	MCTTLFLLSTLAMLWRRRFANRVQPEPSsVDG..AVhGSS.-sDhQSSGRcc..pPlK...	0	1	1	1
+15054	PF15202	Adipogenin		Adipogenin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VDE8	Family	This family of proteins is involved in the stimulation of adipocyte differentiation and development [1].	27.00	27.00	36.10	81.80	26.30	22.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.98	0.72	-4.11	2	20	2012-06-29 13:14:00	2012-06-29 14:14:00	1	1	14	0	8	23	0	73.80	79	66.89	NEW	MKYPLhPLVNDLThSFLVFWhCLPVuLLL.LhIlWL+FLLSQDScEsDSslChsWEPWSKGPuE.shcGThpGQEcc+..W	.MKYPLhPLVNDLTFSFLVFWhCLPVGLLLFLLIIWLRFLLSQDSEENDSsVChDWEPWSKGPAEFCWcuTLHGQEcERPC.h....	0	2	2	2
+15055	PF15203	TMEM95		TMEM95 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q3KNT9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length. There is a conserved LGG sequence motif. The function of this family is unknown.	27.00	27.00	86.10	33.20	21.10	19.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.91	0.71	-4.81	3	20	2012-06-29 13:14:47	2012-06-29 14:14:47	1	2	16	0	8	32	0	134.10	68	76.95	NEW	CVFCRLPAHDLSGRLA+LCSQsEA+pKECGASssFsAFALDEVSMN+VTEKTHRVLRVMEIKcSlSSLPLYWpWLRKTKLPQYTREALCAPAC........RGSTTLYNCSTCcGTEVSCWP+KRCFP.......GSQDLW-A+ILLLsIFGtsLLLGuLSLLVEp+	..CVFCRLPAHDLSGRLARLCSQMEAp.K.ECGASPDFSAFALDEVSMNKVTEKTHRVLRVM.EIKculSSLPsYWpWL+KTKLPcYTREALC..sPAC........RGSThLYNCSTCcGhEVSCWP+KRCFP.......GSpD.h.h+lh.hss.Gss...Gsl.............................	0	1	1	1
+15056	PF15204	KKLCAg1		Kita-kyushu lung cancer antigen 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5H943	Family	This is a family of cancer antigens [1].	27.00	27.00	37.10	87.60	18.90	17.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.14	0.72	-3.95	2	17	2012-06-29 13:15:39	2012-06-29 14:15:39	1	1	13	0	5	20	0	87.10	72	78.31	NEW	QpssGEMSSNSTuLALVRP.SSoG.hpSNTDpN....LuVhsLShDIL.N.P+oIshQKRhLVNLphhp.KLsELEHhLl.KGhpGA.sphKS	....QRNTGEMSSNSTALALVRP.SSTGLINSNTDNN....LSV.cLSRDIL.NNFPHSIAMQKRILVNLphVE.KLsELEHhLVSKGhRGASsHRKS...	0	1	1	1
+15057	PF15205	PLAC9		Placenta-specific protein 9	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JTB6	Family	This family of proteins was identified as being enriched in placenta [1].	27.00	27.00	28.30	27.70	22.00	20.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.45	0.72	-3.70	4	31	2012-06-29 13:16:29	2012-06-29 14:16:29	1	1	23	0	14	30	0	68.10	66	72.19	NEW	AEP.sPutGDsutSsuCDRaMAVpcRLDVhEETVEKTVEHLEAEVKGLLG.LEELAWNLPPGPFSPhPDLLGDs	...........AEPhsPspGDsApSTsCDRHMAVQpRLDVhEEhVEKTV-HLtsEVKGLLGLLEELAWNLPPGPFSPsPDLLG-s.........	0	1	1	3
+15058	PF15206	FAM209		FAM209 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JX69	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 170 amino acids in length. The function of this family is unknown.	27.00	27.00	123.80	123.60	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.79	0.71	-4.39	5	40	2012-06-29 13:17:50	2012-06-29 14:17:50	1	1	24	0	22	48	0	149.80	61	88.16	NEW	FMFSSLREKsKEPQGKVPCGGHFRIRQNLPEHTQGWLGSKWLWLhFVVVLYVILKFRGDSEKNKEQoPPGLRGCoaRSPlRKpQNASPNKDYAFNTLTQLEMDLVKFVSKVRNLKVuMAT..uSNLRLQsLEuPADPaNNVTIYEIWGEEDS	.FMFSSLREKspE....PQGKVPC....G.GHFRIRQNLPEHAQGWLGSKWLWLlFVVVLaVILKF....ptDu.EK..NKEQo.PsGLRGssFRSPLKKsQNASPsKDhsFNTLspLEh-LVKFVSKVRNLKsAMAT..uSNL+LppsEhPADPap.lTIYEIWGEEsS...	0	2	2	3
+15059	PF15207	TMEM240		TMEM240 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5SV17	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 54 and 175 amino acids in length. The function of this family is unknown.	27.00	27.00	94.00	93.90	26.60	21.00	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.32	0.71	-4.70	2	25	2012-06-29 13:18:38	2012-06-29 14:18:38	1	1	21	0	18	34	0	141.90	78	98.56	NEW	Mph.ssThhhMlhGAslVhAIsCl.DMNALLDRFHNaILP+hRG.-RVCHCsCGRHHVcYVIPY-GstSLssuSts..susSVoKQEhDLhLGLLhGFCISWlLLWLDGAhHCAlRhWRuSRaYss...SWpWlsphCNLR-LRRRhQhRp....-suusNhVHl+QKLYHNGHPSPR+L	.................lhGtshh.tIsClMDMNALLDRF.HNYILPHLRGEDRVCHCN.CG...RHHlHYVIPYDGDQSVVDuSENYFVTDNVTKQEIDLMLGLLLGFCISWFLVWMDGVLHCAVRAWRAuRRYDs.....SWoWLPKhCsLRELt+RsH...a...EEssGNMVHlKQKLYHNGHPSPRHL....	0	1	4	9
+15060	PF15208	Rab15_effector		Rab15 effector	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6BDI9	Family	This family of proteins has a role in receptor recycling from the endocytic recycling compartment [1].	27.00	27.00	78.90	78.60	17.90	16.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.66	0.70	-4.91	2	26	2012-06-29 13:19:39	2012-06-29 14:19:39	1	1	25	0	16	26	0	232.30	61	97.83	NEW	MGQKsSQQls.pDSpEV.uhCEVVStAIsHAAQKlKEYLGFE.PLSpLC.AusoLsElFLlHFVTFCQ-+GsDEWLTTTKMTKHQAhLFGADWIWTFWGs-KQIRLQlAVQTL+MuSLP.s-PKsC.....ESRuEE.ShK+uRFDKLpEFCNLlGEDCLGLFIIFGVPGcPKsIRGVVL-SV+pthhpuQLsGRKAVtQFlLETcDClSI+ELLGNCLSK+DGLp-hG+VYIpIL	.......MGQKsSQQls.+DSpEl.slCEVVSpAlVHAAQKLKEYLGFEsP.S+LsPAuNTLNEIFLIHFITFCQEKGVDEWLTTTKMTKHQAhLFGADWIWTFW.GuDKQI+LQLAVQTLQM.....uShPP.sEucss.chsssES+....uE.EsSh+KoRF-KLEEFCsLIGEDCLGLFIIFGVPGKPKDIRGVVLDSVKsphs+upLPGtKAVtQFVL-TE-CVsI+ELLtNCLSKKDGL+EVGKVYIsIL........................	0	1	2	5
+15061	PF15209	IL31		Interleukin 31	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6EBC2	Family	\N	27.00	27.00	27.40	73.30	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.63	0.71	-4.57	4	23	2012-06-29 13:20:31	2012-06-29 14:20:31	1	1	20	0	10	18	0	131.70	46	85.76	NEW	opohshtt.hsppDlp+hl-.Lpp.S+sLhcDYpccE.oGlssspshpLPChS.Dpps.sNI..SuIhAYLcpl+sLScpoV.hsclIcpLsclph.ss.psNISVP..TD.oa-CKsFILTlLpQFSsCMspl.tp.Noss	.........SHshPhthL.P.s.DlpKIlcELQsLSKhLLcDh.ccE...cGV.sSp.shpLPChosDuQsPsNIpSuAIhsYL+sI+p...Ls....s+oV.I-cIIEpLDKLh...FQcsPETNISVP..TD..oaEsKpFILTILQQFScCM-hshtuhsss..........	0	1	1	1
+15062	PF15210	SFTA2		Surfactant-associated protein 2	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6UW10	Family	\N	27.00	27.00	54.80	53.90	25.80	20.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.85	0.72	-4.39	4	17	2012-06-29 13:21:16	2012-06-29 14:21:16	1	1	15	0	6	19	0	57.40	70	70.04	NEW	sGPGMTLQLKLKEoFLssSSYsSSFL-hLpKlCLLLHLPSGTNVTLHpAGS.HHVTCRs	......TGPGMTLQLKLKESFLsNSSY-SSFLELLEKLCLLLHLPSGTsVTLHHAtSpHHVsCps...	0	1	1	1
+15063	PF15211	CXCL17		VEGF co-regulated chemokine 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6UXB2	Family	\N	27.00	27.00	32.80	32.30	22.70	19.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.31	0.72	-3.59	6	23	2012-06-29 13:22:01	2012-06-29 14:22:01	1	1	20	0	12	17	0	89.40	67	76.13	NEW	SPNsGVARGHRDp+QAspRWLpEGGQECECKDWFLRAP+RKhhsV.GhP+KQCPCDHFKGphKKTR+Q+HH+.............Ksp+PSRsCQQF...L+pCp	..................SsNPGVARGHRDp+QAS+RWLQEGGQECECKDWFLRAP+RKlMT..VsGLPKKQCPCDHFKGsVKKTRHQ+HHR.............KPNKHSRACQQF...LKpCQ.	0	1	1	1
+15064	PF15212	SPATA19		Spermatogenesis-associated protein 19, mitochondrial	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q7Z5L4	Family	\N	27.00	27.00	74.00	28.90	18.50	17.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.62	0.71	-4.10	3	31	2012-06-29 13:24:21	2012-06-29 14:24:21	1	2	22	0	17	29	0	101.30	63	85.84	NEW	SSDIEVsESEAVSVVQHWLKKTEEEASRuIK.............EKMSTNsPPTHGQDIHVTRDVVKHHLSKSDLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEsp-DlMRDRIEQVRRSISHLoD-SuQDhShRsSsSEC	...............SSDl-VlEoEAVSVlpHWLKK..............TEEEASQuIK.............EKMShssPPTHGpDlHVTRDVVKH+LSKoshhus.SQEVLEERTRIQFIRWSHTRIFQVPSEhhp-hhp-RIEQVRRShspl.s......t.pss..pC....	0	2	2	4
+15065	PF15213	CDRT4		CMT1A duplicated region transcript 4 protein	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8N9R6	Family	\N	27.00	27.00	82.10	81.90	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.85	0.71	-4.08	6	29	2012-06-29 13:25:57	2012-06-29 14:25:57	1	1	21	0	14	25	0	134.80	61	89.10	NEW	cLTENIGLPlsLLEKHsPWPAYVTYhSPhVKRLIEKSKARDLEChpAlEcsp+su+QSKPSSlhQLKRRKSSKsSGphsLKDThSETMLSsWuuhSsssVuPohlPEPtpLHsDSREsPTuNYNKIIFuR+PhMRhLP	..............t.LTENhGLPhpLLEKHDPWPAYVTYTS.sVKRLIEKSKsRELEChpAlEEsp.hsSRQsKPSSlIQLKRRKSSKSSGcssa+DsLSEosLShWGsYSl.AhuPThlPEPT+lHoDSR-sPTpNYNKIIFuRKPhMRMLP..	0	1	1	1
+15066	PF15214	PXT1		Peroxisomal testis-specific protein 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8NFP0	Family	This family of proteins is testis-specific [1].	27.00	27.00	28.40	48.10	20.30	18.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.64	0.72	-3.71	2	16	2012-06-29 13:26:47	2012-06-29 14:26:47	1	1	14	0	6	16	0	50.90	72	56.96	NEW	MQLRHIGDslsHRhlpEcLtQ-stDsLs.FVhhhFhRsQVLL+FFWNNHLL	.MQLRHIGDSIDHRMVpEDLQ.QDGRDALs+FVhFFFRRVQVLLHFFWNNHLL...	0	1	1	1
+15067	PF15215	FDC-SP		Follicular dendritic cell secreted peptide	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8NFU4	Family	\N	27.00	27.00	75.20	75.00	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.42	0.72	-3.67	2	10	2012-06-29 13:27:30	2012-06-29 14:27:30	1	1	9	0	1	10	0	65.10	68	77.32	NEW	hPVspDQEREKRSh..SDELspth.h.Pas.PFtshPPh...t.PWahh.a..Ph.lP..sPTT.hP	FPVSQDQEREKRSISD..SDELuSGFhVFPYPYPFRPaPPIPaPRaPWFpRsF..PIPIPESsPTTPLP	0	1	1	1
+15068	PF15216	TSLP		Thymic stromal lymphopoietin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q969D9	Family	\N	27.00	27.00	27.90	30.90	20.20	16.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.85	0.71	-4.40	5	25	2012-06-29 13:28:18	2012-06-29 14:28:18	1	1	18	0	10	23	0	101.00	53	84.64	NEW	YNFTNCNFE+IpcIYpslIF+DLpsYlNGhKSscFNphVsC-sRPuCLTKIEpaTFNPlsGCsSLAKKtFAp+TKAALssaCPGYSETQIN.uTQAM+KR...cVssNKCLcQVSQLLcLWRpFsR.....p	.....YsFosCsFpKIpttY.psI.psLhpYMsGsKSopFNpsl.Cps+spCLscIpphTFsPs.tCsSLucch...FAh+TKAsLslaCPGYSETQIN.uTQsM+KRhcccVssNKCLEQVSQL.GLWRcF.R..s....	0	1	1	1
+15069	PF15217	TSC21		TSC21 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q96LM6	Family	This family of proteins is testis-specific [1].	27.00	27.00	176.40	176.20	17.90	17.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.28	0.71	-4.60	5	23	2012-06-29 13:28:57	2012-06-29 14:28:57	1	1	21	0	15	23	0	175.40	72	99.63	NEW	MAGVVYPpQAPVDLDIYQSSYMVDYKPYGKHKYSRVTPQEQAKLDAQLRDKEFYRPlPsPNPKLEDGYPAFRRPHMTA+DLGlPGFFPPQ-HVTTsEDEsRFTSTC+olYPASHsLYLAQGDPNRl+QSADFPCLLEPERQPAsEVGKGYFLLPGCsCsYHppVKVPILNRWGPLMPFYQ	.........MAGVhYPtQsPVDLDIYQSSYMVDYpPYGKHKYSRVTPQEQAKLDAQLR-KEFYRPlPsPNPKLpDGYPAFKRPHMTAKDLGlPGFFPsQ..-+sATtEDEs+FTSTC+hsYPASHsLaLAQGDPNplpQSADFPCLLEPE+QPAuEhGKGYLLLPGCsCsHHp.hVKVPILNRWGPLMPFYQ.	0	1	1	2
+15070	PF15218	SPATA25		Spermatogenesis-associated protein 25	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9BR10	Family	This family of proteins may be involved in spermatogenesis [1].	27.00	27.00	127.00	126.90	17.50	16.60	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.59	0.70	-4.92	3	28	2012-06-29 13:29:44	2012-06-29 14:29:44	1	2	25	0	16	25	0	204.40	78	100.09	NEW	MSYFsSPQTHPGLLPSGQGGAASPGSSLGLYSPAEPVlVASGGQGPLSQKAEQVTPVAQAWGPALAV.EARGCPGGVSWEPPRRKEYNRYCHKhPsARQLESLGWEDuCSRSRAPaLGGPSRPpPLLLCGLSPGALPhPSEAGGKEAuSQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGAQWpQ..A+oHhASGPMALVRSRRGQPPGSCL	.MSYFhoPQTH.G.LPSGQGGAASPG.SLGLhSPsEPVVVASGGhGPLSQKAEQVsPuAQAWGPALAhPpARGCPGGsSWETL..RKEYu.RYCHKFPasRQ.ESLGW-DGsSRSRAP.cL.....GG.....PSRPtPLLLCGLSPGVLPhPSEAsGKEAuSQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGspWEQ..A+A..HTASGpMPLVRS+RGQPPGSCL..	0	1	1	2
+15071	PF15219	TEX12		Testis-expressed 12	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9BXU0	Family	\N	27.00	27.00	31.30	30.80	23.10	20.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.19	0.72	-4.03	3	27	2012-06-29 13:30:40	2012-06-29 14:30:40	1	1	24	0	16	28	0	96.60	76	82.11	NEW	Ms-SP..QlSSLGK.....SDSShLESSGLFYK-EuLEKDLSDMSKEINLMLSTYAKVLSERAAVDASYIDEIDGLFKEANsIENFLlQKREhLRQRFTVIoNTLH+	........................PDSP..QLSSLGK.....SDSSFSEsS.GLFYKDEuLEKDLNDhSKEINLMLSTYAKlLSERAAVDASYIDEIDtLFKEANsIENFLIQKREhLRQRFTVIANTLHR...	0	2	2	2
+15072	PF15220	HILPDA		Hypoxia-inducible lipid droplet-associated 	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9Y5L2	Family	This family of proteins stimulate intracellular lipid accumulation, function as autocrine growth factors and enhance cell growth [1-2].	27.00	27.00	28.90	43.00	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.94	0.72	-3.99	3	15	2012-06-29 13:35:03	2012-06-29 14:35:03	1	1	15	0	6	18	0	62.40	76	95.12	NEW	MKaVLNLYLLGVVLTLLSIFVRVMESLGGLLESPSPGSSWTTRGQLANTEPTKGLPDHPSRGV	MKHlLNLYLLGVVLTLLSIFVRVMESLEGLLESPSPGoSWTTRuQLANTEPsKGLPDHPSRuM........................	0	1	1	1
+15073	PF15221	LEP503		Lens epithelial cell protein LEP503	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9Y5L5	Family	This protein may be involved in lens epithelial cell differentiation [1-2].	27.00	27.00	27.80	44.40	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.01	0.72	-4.27	3	18	2012-06-29 13:35:43	2012-06-29 14:35:43	1	1	16	0	10	19	0	61.10	81	92.36	NEW	MQPpTQPLAQALPFSLRcALpDTGLRVPVIKMGTGWEGhQRTLKEVAYILLCCWCIKELLD	MQPRTQPLAQsLPFSLtGALRDTGLRVPVIK..M.GTGWEGhQRTLKEVAYILLCCWCIKELLD	0	1	2	2
+15074	PF15222	KAR		Kidney androgen-regulated 	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P61109	Family	The function of this family is unknown.	27.00	27.00	171.80	171.60	22.00	19.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.30	0.72	-3.94	2	4	2012-06-29 13:37:42	2012-06-29 14:37:42	1	1	3	0	2	3	0	102.80	75	85.09	NEW	FP..-lsSINcELQsSIhDlLNSs.D.QLuSYcsopuP.ED.T.p-.sTD...hMphT.utshQ.SEhSsssETVSSuFLEEhTEso-.TVchPLA.ssshSsTS	FPLSELVSINKELQNSIIDLLNSVFD.QLGSYRGTKAPLEDYTDDDLSTDSEQIMDFTPAANKQNSEFSTDVETVSSGFLEEFTENTDITVKIPLA.GNPVSPTS	0	1	1	1
+15075	PF15223	DUF4584		Domain of unknown function (DUF4584)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A6NHQ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are approximately 835 amino acids in length. The family is found in association with Pfam:PF02437.	27.00	27.00	29.50	29.50	21.00	26.20	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.55	0.70	-5.20	8	68	2012-06-29 13:50:24	2012-06-29 14:50:24	1	3	37	0	39	59	0	321.00	50	52.29	NEW	pPPlhhpssF+hpssssssspps....tssssGhDsppp.Kspss-ph.s.pthssuusssssPsSl..s.s.hppp............t.pssspRTD..........ss......oPsPptspsF.Ppp+h.......Pupsspsssus.ss.ss.pp............s.ssp.t+c.+hs.s.phsoslc+hp.-.........PpssucpsAcoPssh..s.s.PFpL+Nl+lKlE-....-EaEhthpssclpCcscsuctp..s...hKptD......p......stpcssu....s.s.......sLcsPss--Gtp+sss+..Ksh+s.l.tp+...t...ssA+sstKssRps+ssu+ossspto.t.............tht.h......sRRK+...AssssuPsKpsFSLMANFPsPPoLllGpDGDLsPAYSLNop+sspPPP.uHPlW+WQlGGsslP.PPu........pKhRKh	..............................................................s.ssh.hpssF.Yp.tsttt.pt........p.tt.....pp.ttpp...h.s..thsshss.h.p.suhssshschppc....t.....c.p..sssppTD..........................ss.t.ss.SPusppspsF.s.pRh.......htpspKC.psh.ss.sspsp...................................................................p.t+.s+h..s.ch......sosl.p.ps-s.................................tstssttsts..........t.PF.LHNlKIKlE-su..-EYE.ph.....spplKCcssssctph.s.st.cpp-hhh..thc............sppcssuh.s......hs.....ps.......sLsoPps--GEhK.sA+VpKNaRoLVLGK+..h.ps..sPsKsshKssRSPRPsuKo.............popEu.oLc.............shssh......sRRK+..sAuNs..sSssKpsFshMANFPCPPSLllGcDGDLhPAYSLNop+DSpPP..AHPlW+WQlGGsAlP.P.Pu........pKFRKa........	0	4	7	14
+15076	PF15224	SCRG1		Scrapie-responsive protein 1	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:O75711	Family	This protein family has an important function in acting against the prion protein, Scrapie [1,2].This family of proteins is found in eukaryotes. Proteins in this family are approximately 98 amino acids in length.	27.00	27.00	126.90	126.70	20.80	19.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.92	0.72	-4.16	2	33	2012-06-29 13:53:27	2012-06-29 14:53:27	1	1	27	0	19	25	0	76.80	81	79.22	NEW	hPupR.SCY++IL+s+sCHSlPEGhAsLp+lD.slQDHFW-GcGCEhlCYCNFpELLCCPK-lFFGPKISFVIPCNsc	.MPuNRLSCYRKILKD+NCHNLPEGVADLTpIDV.NVQDHFWDGKGCEMICYCNFSELLCCPKDlFFGPKISFVIPCNNp.......	0	1	2	5
+15077	PF15225	IL32		Interleukin 32	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P24001	Family	\N	27.00	27.00	69.50	63.00	22.50	18.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.45	0.72	-4.09	2	18	2012-06-29 14:50:41	2012-06-29 15:50:41	1	1	7	0	1	29	0	92.30	85	50.78	NEW	E.TPLL.c.RptLRsRspRSsVPslED.uhE..-PtESFhD+shRhFQthLppLQphWpuVLAWV+chVs....ALspAVpAlWp.FQsFCs.luplhhSuhQu	.ELTPLLEKERDGLRCRGNRSPVPDVEDPATE..EPGESFCDKVMRWFQAMLQRLQTWWHGVLAWVKEKVV....ALVHAVQALWKQFQSFCCSLSELFMSSFQS...	0	1	1	1
+15078	PF15226	HPIP		HCF-1 beta-propeller-interacting protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NWW0	Family	HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localisation. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus [1].	22.10	22.10	24.20	22.10	19.20	17.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.66	0.71	-4.05	9	35	2012-06-29 14:59:46	2012-06-29 15:59:46	1	1	28	0	17	37	0	118.50	66	81.84	NEW	ILQQPLERGP.GtAQRDPRAAoGsohGLDs...................REPLRKQFLSEENMATHFSRLSLHNDHPYCSPPhsFPP.ALPPLRSPCSELLLWRYPGsLIPEALRLLRLGDTPoPaYPAoPAG-	......................................ILQQPLERGP.GtsQR.PRAA.GsotGLDAs........................pEPLRKQFLSEENMATHFScLSLHNDHPYCSP..PhsFP...P.ALPPLRSPCSELLLWRYPGsLIPEALRLLRLGDTPoP.YPAoPAGD.....................	1	3	3	5
+15080	PF15227	zf-C3HC4_4		zinc finger of C3HC4-type, RING	Coggill P	pcc	manual	Domain	This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development [1]. This domain is likely to be DNA-binding [2]. This zinc-finger domain together with the RDM domain, Pfam:PF11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme [3].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.66	0.72	-4.08	13	3078	2012-10-03 15:03:13	2012-08-03 15:33:49	1	84	232	5	1547	3331	31	42.10	42	9.14	NEW	CPICh-YLccPsolpCGHsFChsCIsshpc-scut....hhCPhC	.....CsICL....-.hh....p..-.....PV.o.l.s.C.GHsFCpsC.l....p...p...h.......a...p...p.....t....p...t.t..............hsCP.C....................	0	267	479	886
+15081	PF15228	DAP		Death-associated protein	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A0PJW8	Family	\N	27.00	27.00	31.40	30.90	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.73	0.72	-3.26	49	159	2012-08-06 10:09:36	2012-08-06 11:09:36	1	2	102	0	88	149	0	90.50	37	87.26	NEW	KuGHPPAVK.AGGMRIs.p++.........t..pscpcp.psc.sppcs.hpphssss.h.......lhloGslsKts+DFP...spAspshH.p....KPpPul-ptsss...pth....h...............pQPRK	....................KuGHPPA...VK.AGGMRIs.pKp..........sscpcpppp.ttppp..ps.ssss.h.......shloGslsKhs+DFP...ssuspsAH.p....KPpPul-Khsss....cp....I.....QQPRK.........................................................	0	22	29	56
+15082	PF15229	POM121		POM121 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NNC1	Family	\N	27.00	27.00	27.50	27.20	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.36	0.70	-4.93	32	248	2012-08-06 10:20:27	2012-08-06 11:20:27	1	5	42	0	92	193	0	179.20	33	32.00	NEW	L+Es.t++ss.ccE-.hhs-u.......-s+RRps-ostpu.SAFcPLhssGs.uSFVP+PGsLKRulpspsS-cshsK.RSpsSShSSh..ssh.sthP..opRNAIoSSYSSopGhsphh..KRs.........suoopsQhPcpPsKKtpcc...tpp..s...ssPhhosp..ttt............s..p..s..sussosuuStp.++.....RKlPLL..ssppG-.LsLPPPPQLGasVTsEDL.-LEKKAulphhNpsLEs	.............................................................................................................p...t...p.c-.h..pt.......psp+p..psstt.h.Ss.cPL.tpGs.sshhspP..tsLptsh.pspp.o.-.p.sp.+upsS.hSSh............spRNAIs..SSaSSotGhsthh..+Rps...............Puoupsphs.psuKphpcc...............ss.hssst...ptptc+......ss.sshpp.s.tsu.s.pst..uSt..p+......+.K..h....Ll..........pttt-.l.LPPPspLGa.lstcDl.sht+cuthph.pphh.................................................	0	25	28	36
+15083	PF15230	SRRM_C		Serine/arginine repetitive matrix protein C-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A7MD48	Family	This domain is found near to the C-terminus of Serine/arginine repetitive matrix proteins 3 and 4.	27.00	27.00	30.50	30.50	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.59	0.72	-3.89	14	73	2012-08-06 10:34:30	2012-08-06 11:34:30	1	2	35	0	39	59	0	67.70	64	12.36	NEW	hSt.p+p...sRE+-pcscspc.pcsctsRtRRRpRSYSPl..RKRRRDSPSahEsRRIT.......SA......RKRPIPYYRP	......................................hS+ao.....uRERDschpp+c.pppc+pR.ARRRRRSYSPh..RKRRRDSPSHLEARRIT..........................SA...RKRPIPYYRP...........	0	3	5	16
+15084	PF15231	VCX_VCY		Variable charge X/Y family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O14598	Family	The variable charge X/Y (VCX/VCY) family of proteins has members on the Human X and Y chromosomes, is expressed in male germ calls and may play a role in spermatogenesis or in sex ratio distortion [1].	27.00	27.00	43.00	28.30	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.17	0.71	-3.80	5	104	2012-08-06 10:46:14	2012-08-06 11:46:14	1	6	8	0	12	91	0	92.90	61	104.49	NEW	MAPKhRASGPPAKAKETRKRKSSSQsSPSoPKK....sPKlAKKGKAuRGGRGGKKRAA.cKM..AAVsAPEAGSGPAPPGPScPPSQELPQHEL.P.PEEPVSEGTQPDPLSQETQL....................EDPLSQETQlEEPLS-tt....lpps.p..opl.p.........-PLS	.............................................................................................................................-PLSQEoplEEPLSQEoplEEPLSpEop.lE-P.pQpoph..................................	0	12	12	12
+15085	PF15232	DUF4585		Domain of unknown function (DUF4585)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:E7EW31	Family	The function of this protein domain family is yet to be characterised. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs.  This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells [1].	27.00	27.00	36.70	39.10	22.90	18.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.68	0.72	-4.12	13	64	2012-08-06 11:01:28	2012-08-06 12:01:28	1	2	28	0	39	60	0	71.60	48	6.08	NEW	pssassTQ+KlL.DPcSGcYalVDhPl..Qs+hKphaDPETGpYVcVslPsSttu..tssss.shs.uPhsLhPuhaPs	...p.shstTQtKlLlDPpoGpYYlVDsPl..QPph+pLFDPETGQYV-VslPs.sp.s...shssh.hs.sPlALuPGhYss.........	0	3	9	13
+15086	PF15233	SYCE1		Synaptonemal complex central element protein 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A8MT33	Family	This family of proteins includes synaptonemal complex central element protein 1, a component of the synaptonemal complex involved in meiosis, and synaptonemal complex central element protein 1-like, which may be involved in meiosis [1-2].	27.00	27.00	27.20	27.20	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.83	0.71	-4.23	17	64	2012-08-06 11:54:32	2012-08-06 12:54:32	1	2	29	0	32	68	0	134.00	58	50.35	NEW	tGSLEPpIE-LIsRIN-LQQ...AKKKusEELGEspslh-ALp+ELDSLsuEKlHLEElLs..KKQEsLR.ILQLHCQ-KEoEuphp............................RhcF...Ep.QLEpLhpp...........HKcL......WEF+h.sppLupEIssl-su..KEQLLpE	.....................................GSLEPplEsLINRINElQQ...AKKKusEELGEApslhEALp+ELDSLpGEKV.+LcElLs..KKQEsLR.ILpLHCQEK.......ESEApRp..psh...h.....................RLsFEE.QLE-LMGQ...........HKDL......W-FHh.sc+LA+EIssL-SS..KEQLLpE.......................	0	2	3	5
+15087	PF15234	LAT		Linker for activation of T-cells	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O43561	Family	\N	27.00	27.00	28.90	36.50	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.73	0.70	-4.88	10	45	2012-08-06 12:03:20	2012-08-06 13:03:20	1	2	25	0	17	36	0	221.60	68	95.17	NEW	MEsslLl.PssLGLLLLPLLAVLLhALCVRCRELPG..SYDSA..........ooDSLaPcSIlIKpPt...TluPWPPAs.Ys.VTSaPPLSQPDLLPIPRSPQPPGGSHRMPSSRQDSDG.ANSVASYENE...........................EPACEDsDEDEDEEDYHNE...GYLlVLPDSoPATSou....VPs.APVPSNPGLRDSAFSMESG-DYVNVPESEESA-ASLDGSREYVNVSQELQP...sARTEPATloSQ.......ps---EEEsAPDYENL..QE	...........MEtshLl.PslLGLLLLPlLAh.LhALCV+C+cLPG..SYDSs..........SSDSLYPRu.I.lK+Pp...TlsPWPPAh..P.VTSYPPLSQPDLLPIPRSPQPLGGSHRhPSSRpDSDG.ANSVASYENE..............................................EP.ACED.-tD..EDEDDYpN....GYLVVLPDSoPAoSou....ssu.APs.SsPGlRDSAFSMESh-DYVNVPEStESA-ASLDGSREYVNVSQELpP...sA+TEPAslsSQ.......Et.-psE-EtAPDYENL..QE...........	0	1	1	2
+15088	PF15235	GRIN_C		G protein-regulated inducer of neurite outgrowth C-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O60269	Family	This represents the C-terminus of the G protein-regulated inducer of neurite outgrowth proteins [1].	27.00	27.00	63.80	59.70	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.10	0.71	-4.09	16	86	2012-08-06 12:19:08	2012-08-06 13:19:08	1	1	34	0	51	88	0	133.70	48	21.15	NEW	+SVATuPhpss.............s...pststsa...............PEVplc.........s.pcspp.PVR-VsWDEcGMTWEVYGASlDsEVLGhAIQKHLEhQIEpa..QhtP.....st.t.pts.....................ppssspppt+Rps...FRshhpslR+PsCCsRuusss..E	...............................................................+uVtsuPhhst.................sutsthh...............Ppsphc.............s..ctspPVRDVsWDEcGMTWEVYGASlDsEVLGlAIQKHLEpQIcEatcphts.....t.....ts........................................................p.spssspttt+Rt.sh.FRuhlQslRRPsCCsRuusu..............................................................................	0	4	9	16
+15089	PF15236	CCDC66		Coiled-coil domain-containing protein 66	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A2RUB6	Family	This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure [1].	27.00	27.00	27.00	27.40	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.18	0.71	-4.61	19	118	2012-08-06 12:25:34	2012-08-06 13:25:34	1	2	69	0	69	126	0	148.20	35	16.22	NEW	sssssttspsspptpsspsspssshps.p....p.saLRuhoA.LLDsup.....lpER-cRRpKthEaQcAIttQlEE+c+hKphEcpp+ppEEppEEpRltRE+pphpcpaEc-hhcp+pKEEhhppKTptLhpshp+ApEhApc.K.pc......................pRh+cltpcsc-hpph	..............................................................p.......tptp......saLRu.ss..lDstp.....ltE...R-c+RpKQhEappAlptQlEEK+p++phEcEp++pEEpcEE..pRLAc-Rp.chQcp..aEE-hh.+p+pKEEh......phKspcL....hpshpcApc.Ap+hK.pc................................................pRh+chtpctpt....h.......................................................	0	20	24	41
+15090	PF15237	PTRF_SDPR		PTRF/SDPR family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95810	Family	This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway [1]. PRKCDBP appears to act as an immune potentiator [2]. PTRF is involved in caveolae formation and function [3]. SDPR is involved in the targetting of protein kinase Calpha to caveolae [4].	27.00	27.00	28.60	28.10	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.65	0.70	-4.97	30	215	2012-08-06 12:39:37	2012-08-06 13:39:37	1	2	43	0	103	180	0	216.10	41	68.95	NEW	QlsAlTVloLLDKlsshlDsVQpsQpphEpRQt-hEsu....V+sIQu-lsKLo+uHssTSsTVsKLLEKsRKVSsplKsVRsRl-+QusQVKKLEsNcscLL+Rs+F+VlIaQ-EsElPuplsspp.psh......................t.t..t.....pch.tshcL.SSDEE..h.l.............................p.hEESRAcRlKRSuL++VDsLKKAFS.........................................................................Rp..................sl-KKhs+luT+I.VsPERREKI+......cKShpss+t.stc..KposhKlsPh	...........QlsulhVloLLDKlhshlDplQtsQtphEpRQ..tphEsu....VpuIQs-LsKLo+uHssTSsTVsKLLEKsRKVSspsKsV+tplE+QssQlK+LEsNcscLL+RppF+VlIa.Q-EsclPupl.hpt.t.h............................t..s.ptpt.cct.tshpLSSD--.h.l...............................-ESRAp+l+RSuhc+VDslKKAFS....................................Rp..................sl-+Khs+lsT+l.VssERRE+h+........pShp..+...tp..Kps..pssP.........................................................	0	4	15	39
+15091	PF15238	FAM181		FAM181	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:A6NEQ2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 426 amino acids in length.	29.00	29.00	29.00	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.20	0.70	-4.35	20	80	2012-08-06 12:48:17	2012-08-06 13:48:17	1	5	39	0	48	70	0	248.20	35	73.36	NEW	tsscpss+sLLsFls.ASSsIKhALDKsu.s+RpVsHRKYLQKQlKRhSthhsthP.t....Pspsspsps...+...tstststp...pspssspppustus.........shp.........pcSLuu.......................................t.h.tt.s.s...scp.VPLR+RsLPsSFapEP.....psspsh.....sussssslss...............scsschh-lLGP-..................sshsscps.h..ss...t...olss+..ssshss.....sPh.acupslhtu...hstsh....s.....sssshssls.hp..ss.s...........sscshp.sttss..up.hh.pssl.cs.sspsu	................................hsscpss+.LLsFls.ASSsIKhALDKsu.s....+RpVsHRKYLQKQlKRhSthhuthP.s............Pspssts.h.......+........us.ts........s.ht..h.s.ssspp.ustss...........tsshp.........pcsLut......................................tt..ttpsstu....stpVPhRpRpLPsSFapEP......p.spuh......sG.psuLss........cutcsschhE.LGP-...................ts..tp-shhh.ss.......uhssh..sss.ph.....pPh.acspshhsG.....s...sh......s.s.hssLsh.+..ss.............shc.ha.sttss..up.........................................................................................................................................................................	0	12	15	25
+15092	PF15239	DUF4586		Domain of unknown function (DUF4586)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A7E2U8	Family	This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.	27.00	27.00	27.00	31.40	26.80	26.20	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.38	0.70	-4.87	41	143	2012-08-06 12:48:46	2012-08-06 13:48:46	1	5	80	0	94	135	0	260.60	27	87.27	NEW	csch-RhGLFS-.sa......lolGDpYhp.tpp......scssscsKpMLsuusKpts.shpsuYFs.pahplhpGEsY........tD.s+hcRphclcptKK..slu.KsFhPusGtKp.s.GhGsaaGsass.h...h........hss.p+spcthh.sts+........NhhTNPuK+Go.aGYsslTlup...sass..DsY-pt+chtccctpc+cphh......cG.ssF+h..shaspcaFDss.Pa.........h........pppsl..sPhcp.t.ttpphstP........FKPosP.....sc..t......ut+sGsFss.aPpapsDPhs.chpp..t..hpspp..............tt+hF+PssssK.o........pPssSIhstslp..+ph	.....................................................................hhGlFSp.sa......lsl.G.....DpY.p.htt.......tstsps+phls.s...ssKp.h...phpsuaF-.pah.plhpG-sY........hs..........p..hp+ptthcptKK.........sls.psFhPss..s.Kcss.GhGsaYGshst.h...h..............hsstt+spcthh....s.s+..............NlhTsPuK+Go.YGY..ss...l..slup...pat..........-.Y-ttc...cpppppccphh......hu..ssF+....shhstt...hFDts.sh........h.............ppsh....s.pp.....ph..ht.s........a+P.pP.....s...t...........uhhtGshs...aPpa.tDPh.ht.tp........pt...............tc.ahPssssp.s........h...Sl..........h.................................................................................	0	50	62	78
+15093	PF15240	Pro-rich		Proline-rich	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P02810	Family	This family includes several eukaryotic proline-rich proteins.	27.00	27.00	28.10	27.00	26.50	26.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.38	0.71	-12.12	0.71	-4.18	16	217	2012-08-06 12:57:24	2012-08-06 13:57:24	1	10	16	0	45	325	0	107.60	39	99.71	NEW	MLlILLoVALLALSSAQs.sE-VupE-ssSllu.....tt...........tsps.t.spp.Qt...........PP.GG..spsP...........................................................................................P.sGGPQp.pPPQsGp....................PpGPPP.GG...........................................ts.......tp.QGPPPQtGsp.....tPP.Ps......................pPQGPP....................t.........................s.sGss...................QtPPP.........PPsGpPQG..PP........................tPPQsG.pPptPPQ	.................................................................................................................................................................................................................................................................s..t..tsQt..PPpsGp..............pGPP.PQGs.sp.......t..sspP.....Gp.QGPPPQGGsQ....tPP.ss.........pPpG.PPsQt...s.........................................................................................................................................................	0	21	21	21
+15094	PF15241	Cylicin_N		Cylicin N-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P35663	Family	This is the N-terminus of cylicin proteins, which may play a role in spermatid differentiation [1].	27.00	27.00	31.90	30.20	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.40	0.72	-4.18	22	69	2012-08-06 13:08:30	2012-08-06 14:08:30	1	1	23	0	27	48	0	108.90	52	24.53	NEW	QclNhsTYDNhIPlSE.S+KSWNQpHFuLsFPKPPpPG+K+RS+PSpLp...sVP....+p-ccKlccspKs..lWh++SLh+I.pRPSlYLAsRRQs.Ph+.shsspscscpApsc	...................cVNhtsYDN.IPlSE.S+KSWNQpHFALsFPKP.pPGpK+RS+PSplp..TVs....hhDccKLcpspKs..lWh++SLh+I.pRPSlYLAAR+Qs.Ph+.sassKscsKpAE.......................	0	2	2	3
+15095	PF15242	FAM53		Family of FAM53	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q14153	Family	The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation [1]. It is known to be highly important in neural tube development [2]. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.	27.00	27.00	28.70	27.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.39	0.70	-4.88	20	155	2012-08-06 13:28:35	2012-08-06 14:28:35	1	2	41	0	67	126	0	256.80	38	76.63	NEW	MVhllTcpLpppuh...DDlss+ohshs..apsccho.pussLFshsls..-s..pWpslstsssl.....ptcss...usShtshhssh.t......h..tuhpW.........p.-uss.ssslouLlpcLSLs....-ssu.....sPsAPPSKRpCRSLShsDELupC.RSsWRPtGSKVWTsVcKRRCpSGGSlphts.......p.tsG.sshQRSoShSLPupus......h....hspt..h..shsutss.sssstuupsss......t.t.hs.pRpLSLSpEpl.shsc....suAs..SoPsSTPELuRRsGt.......LsRSRSQPC..VLsc+KsuhKRRRsEDs+hpRPSLD..hsKMTQ	.......................................................................................MlhllocpLpppsh...Dpltpptht.t........scphs.pussLhshtl....-s.s.W+sLs.ttssh....p.pts...s.sh...................u..W.........p.puss.sst.pshhpsLshp............-pts.....................sPsAP.PoKRpCRSLS.s-E.hu..psRosWRPtuSKVWT.PVpKRRCtSGGSsph.p..........ss..thpp.pshsLPppss.hs.........h.pt.hh..s.t.tsu.hs...supusps.u....s..t.s.hs.pRphSLSpEph..phsp.......PSAs................SoPsSTPELsRRtu........L.RsRSQPC..VLss+KsthKRRR.EDs...p..pRPSLD..hhKMsQ.................................................	0	5	10	25
+15096	PF15243	ANAPC15		Anaphase-promoting complex subunit 15	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P60006	Family	This is a component of the anaphase promoting complex/cyclosome [1].	27.00	27.00	30.50	37.60	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.53	0.72	-3.92	25	114	2012-08-06 13:34:13	2012-08-06 14:34:13	1	2	81	0	67	91	0	93.20	45	78.43	NEW	Ms.....shFPsLhPRls-shWFsl.D...............cPCsEEsELp.........p.EQpHQsWLpSIuc+sssLlPIGKsssE.............pct-s---....-sp--s..-csEptpp-p-Eh--h	........Ms..shFPSLhP+lT-oLWFNl.D...............+PCsEEoELp.........ppEppHQsWLpSIuc+ssNL...lPIGKPsoE................tp-c--pD-E....-s--Du......--sE-..pD.DEhsD.......................	0	11	20	40
+15097	PF15244	HSD3		Hydroxy-steroid dehydrogenase	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9P0W8	Family	This family also goes by the name of Spermatogenesis-associated protein 7 or SPAT7. It is an aldo-keto reductase (AKR) human type 3 3-alpha-hydroxy-steroid dehydrogenase (H3-alpha-HSD3, AKR1C2), and it plays a crucial role in the regulation of the intracellular concentrations of testosterone and 5-alpha-dihydrotestosterone (5-alpha-DHT), two steroids directly linked to the aetiology and the progression of many prostate diseases and cancer [1,2]. Mutations in the gene cause Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP), the most common hereditary causes of visual impairment in infants and children [3].	27.00	27.00	28.10	27.50	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.49	0.70	-5.23	10	108	2012-08-06 13:52:06	2012-08-06 14:52:06	1	3	48	0	44	107	0	234.10	43	66.25	NEW	+VRuosVLPRYuPPCLFKGHLSTKSNAFCTDSSSLRLSTLpLlKNHMAVHYNKILSAKAAVDCSVPVShosSIKYADQQRREKLKKELARCEKEhKLoKouhQANSKssSKSlhNoLQKPuGEPQsctshllEchNpFsSFu+SllsSSE+LcLu.LsKSscslosGocKNuSSS.oSh.............-hssSsPR+ssSussauR...+PRSshssSHR.FQLVlSKAPSGDLLDKHSEhFSNKQLPFTPRTLKTEAKSFLSQYRYYTPAKRK.KDhoDQcIEAETQTEL.SSF+S-hsTAEpKshT-SElNIpQA..SsCsTaGTK-KhsPhstptpsLsW-cl.K-ssLQpSSsRu.lCpYSlQ..Pus+KIaS-EEELLYLSFIEDVTDEILKLGLFSNR.FLERLFERHI+QNKHHLEEcKMRHLLHlLKVDLGChS	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p....t..c.......-EhhYlpFhtslTp-llphGlaos+..LpplFcpHlppp+.pLpttph...h..Lp.p..................................................................................	0	11	13	27
+15098	PF15245	VGLL4		Transcription cofactor vestigial-like protein 4	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14135	Family	These proteins act as transcriptional enhancer factor (TEF-1) cofactors [1].	27.00	27.00	28.30	27.20	24.00	25.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.90	0.70	-4.50	18	112	2012-08-06 13:52:32	2012-08-06 14:52:32	1	2	63	0	55	101	0	186.70	47	66.05	NEW	LLNaQYLDKM.NNNIG...lLpYEG....pstLRuEsRhpoLs......................thoscRTuPPPlsPoKRKhSt-QuDsch-p-s-HhoKMSRhFusp..Lsp....s.st-..Rpc......php+u+......SPh-phsss.o.ulhus.HlYuoh............sshu.hDQPLAL.TKsoh.-us+o.....tthsspssssER.QNRPSVITCAPAssRNCNLSHCs..shsusss....s.++.s....sTuCDPVlEEHFRRSLGcNYKEs	...........................................................................................................................................h....ht.......pt..............pstL+.u-sRhpsLsh.....................shospRTsPPPlsPsKRKhSh-.uDpch-p-s-HhoKMSRhFss+..Ls+....ssNGDp.Rc-.........R-RSR..........SPIER.usus.ohoLHus.HlYsSh.................h-QPLAL.TKNSh.-uuRs......ths.shsssERQQNRPSVI...T.CAsAs.sRNC..NLS.HCs.hsHsuCss.hss............................t.ssssssCDPVlEEHFRRSLG.KNYKEs........	0	9	14	35
+15099	PF15246	NCKAP5		Nck-associated protein 5, Peripheral clock protein	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:O14513	Family	NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role [1].	27.00	27.00	82.30	38.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.26	0.70	-5.05	20	107	2012-08-06 13:52:54	2012-08-06 14:52:54	1	2	37	0	48	83	0	261.60	41	20.62	NEW	slpsoIEEKVMhGIpENVpKsQtQsKu.sosEsKQKsuPSlASWFGhRKSKLPALSuRKsDsuKsK-EKK-hKhhuhssppthscc++ccKctppphplss.hs+sp-htc..p.-puhhspps.cpspcstsp.........hppttpph.s.sstsspDsFMpELLNRVDcKsstpscpssspsshpshp+uSspupsh.ssshuspusp++.hps+hphptsppsh......htpts-phpc-Epss.sDos....hQsHhlsSusQhRTLDSGIGTFPLPDSssRusuRpsspppps.cp-s.sshp.shsssssl.+....ApTLEREVPSss	.............................................................................................................................................................................s..pssIEEKVMhsIpENV.+hQsQp+u.susEsKp+s.ssShASWFGh+KS+LPALs.R+h-soKsK.t....thhu....s.pp..schctc.Khtt.phplpp.ht+spc.tc..p.-puh.spps..pspshhst.........ht...tph.u.ht..stDsFMppLLN.R..VDtKth..pp.tpspsphtsh..soopsps...suhuspss....hhs.hphpt....th.......................ssEshpc-E.ss..-sh.....psHhhtsss.hRTLDSGIGTFP.PDpGsp.ussph.h.tsps.ch-s..sl.su..t.sssh.+....ApTLEREVPu..p..........................	0	2	5	16
+15100	PF15247	SLBP_RNA_bind		Histone RNA hairpin-binding protein RNA-binding domain	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14493	Family	This family represents the RNA-binding domain of histone RNA hairpin-binding protein [1].	27.00	27.00	37.20	39.80	26.90	24.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.61	0.72	-4.21	52	232	2012-08-06 14:32:12	2012-08-06 15:32:12	1	2	135	1	151	227	1	76.20	47	23.06	NEW	hEsD.p......pLtpRQKQ....I-aGKNThGYppYlppVP.+ppRp..p.....tHPpTPsKapphSRRuWDupl+hWR+tLHp.a......D...........Ps	......................EpDpp....hLtpRQKQ....IsYGKNThuYc+YlctVP.+c..tRp.......shHPcTPsKap+hS+RuWDtpl+lWRptLHh.aDs........................	0	62	84	119
+15101	PF15248	DUF4587		Domain of unknown function (DUF4587)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:P58505	Family	This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.	27.00	27.00	44.40	44.40	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.13	0.72	-3.38	28	70	2012-08-06 14:40:19	2012-08-06 15:40:19	1	2	34	0	36	68	0	68.60	47	28.36	NEW	RsGuI..KEDMVEhMLhQNAQMHQllMpshMl+ALPPhs....s..................stssslcspc.....pcPssVHHHHaa	.......+sGplKEDhVEhMLhQNAQMHQllhpNhML+ALPPs.s....st........p....s...p.hhhcspc...pcPssVaHHHa................	0	4	7	14
+15102	PF15249	GLTSCR1		Glioma tumor suppressor candidate region	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NZM4	Family	This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. There is a single completely conserved residue F that may be functionally important. Mutations in the gene for this protein in humans leads to the development of oligodendrogliomas [1]. There is evidence that these protein interacts with SH3 domains [2].	27.00	27.00	27.60	27.40	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.51	0.72	-3.95	54	193	2012-10-03 11:11:44	2012-08-06 15:41:14	1	6	115	0	126	197	0	109.40	33	10.45	NEW	htpphttcptt.......shpP...........Dh.p...sPFpo..hpDAlcRL..LPYHlhtp.p.s..........pDhpt........................hDcp......hcspssp.h..hp+hpphhp+aphllhccut......cts...spEtlh...lpphhhp-E+pplpc	...............................................hppLppcpst....................shpP...........Dh.poPFpShcDAlpRL..LPYHVhpss.sst.................pDhpp.......................................................................hDpc......aEshusp.h..hc+hpthlsKaphlLhc-uh......chss..osEhlM...l-phhlp-E+tplt............................................................................	0	38	57	88
+15103	PF15250	Raftlin		Raftlin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14699	Family	This family of proteins plays a role in the formation and/or maintenance of lipid rafts [1].	27.00	27.00	30.90	41.60	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.61	0.70	-5.96	19	145	2012-08-06 14:45:02	2012-08-06 15:45:02	1	6	38	0	65	124	0	348.00	40	86.42	NEW	MGCGLRKLEcsDDsSPGKIaSTLKRPQVETKsDsAYEYhhLDFTl..pu..ss.sssl+luSlhDlPsplp-hYpQGalluAlHPhlpPsscpcplPtpplaRAlLl+hp.p..ppcss.hspct.pLhlEECs.stcshss-hlppLIcK.lp-AAcpGh+FVGhl.........spths.spssssos....sstsh-.c.s..........................................tthcpss-css+s.......spush.sspss-suhcpchptpss......h.......ss.s.sp.........ch+LaslFNt.c......c.spsChpYapsslsh+VoRpGpslSoL-AsWLEhhohaa+pG.hSLVDuasphshs+.Dpls+sl-GlFIaEEtuousstosp.G.DAIVVEQWTVIEGsEVKTDYsPLLpoLApFGWhLTCVLPTPIl+ps.SEGNLATKQlVFLQRPsh.pp..stpp.p..........cppsRph+p..cpppsuscp.s...tp..ssE	...............................................................MGCtL.KLc.c.--.p.pPGpIaSTL+RsQVET+ht.sYpYhhL-F.h....tu..stspslplsSlh-lsspl.-hY.pGa.lsAlHPhlpPsttpcphP.phlaRslL...+.p.p...ppp.ss..tpp..t.hL.l-pCs.h.p..spchh.thlcK.lp.uAppGh+FVGhl.........................p.hs..t.ss.ss.........p....................................................................t.....................spsp...s.t.p..pthp..pp.pt.pt..............t..p.shst.........c.claslFNt.c......s.pppshpY..shlsh+Vo+pGps.losL-AsWLEhho.aa+pG.h.Llsuhhhhth.s.p....-p.h.t.h-GlFIaEt.ustssto.p.G.DAIVVE.QWTVlEG...sElpTDYsPLLpoLAtaGW.LTsVLPTPll+ps.pEGsluTKQlVFLQRPsh.pp..htpp.p..........cht.t+..pt..t.t..sttp.t..........tt...................................................	0	3	9	26
+15104	PF15251	DUF4588		Domain of unknown function (DUF4588)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14CZ0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 274 amino acids in length. There is a conserved LYK sequence motif. There is a single completely conserved residue A that may be functionally important.	27.00	27.00	27.20	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.82	0.70	-4.38	18	156	2012-08-06 14:50:59	2012-08-06 15:50:59	1	2	115	0	102	137	0	208.80	31	89.72	NEW	EppCl..s-up.ccp..........................t.pssphpsppp+LWptFpsuAsAVApLYp...................t...................t.thohWssFpsAAtuVTsLYK-Ss.DuppRSh-hGhpsGhpc......Rs+DllpWs+.+tRphIRRE-LluaLsG+sPPs......+s.sps..............sscs........ss..sssp.....p..ts.t.s.s......l-ssLpsF+-AluLtt..hsshhsshuh.susPsossp.pt.t.......................uhpcscLsshhs...--lshp.............pRKRppspss-s.............sSPoHKRsR.hh	........................................................................t....t.....pplh..FptsApulApLYp.........................tp.shuLWssFQsAAsuVTsLYKpSs.-spp+oh-hGhphGhpc............................cs+-lhsWs+.KpR.ph..IRRED...LluaLsGKssPs......ps..pt.............................ssp................st.......t.....tssss........spsshp.sh.ppsluh.....st.hss.phtss...Ps.sst....t.............................t...............tpht.................p...t.............................h.......................................................................................................................	0	24	37	70
+15105	PF15252	DUF4589		Domain of unknown function (DUF4589)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q2T9L4	Family	This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.	27.00	27.00	97.90	60.20	20.50	25.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.70	0.70	-4.53	13	97	2012-08-06 14:54:27	2012-08-06 15:54:27	1	2	37	0	58	73	0	209.90	48	85.56	NEW	EVVsQID+LTSDh-aELE..sDDWTTuTlSSTSSS-+...sGss.-Lt+LDFhsuDhLSD..........SW-FCSFL-tSsPsssssssssspsts...................ssapLMNGGl................IPNGPth.TPDSSSEEA.sss........Ksp.....pRTsGTRERVRFSDKVLYHALC..CDD-p-tsppp...ctp..t....p............................sPc..sssuhssutstshsst.....s..++lhRNoSTQTVuDKSTQTlL	........pVVsQIDpLTSDhphE.E..sDs.pTsTlsSoSSSsp.........s.sLt+lchhsss.L.c...........s.thhohLchssPssssst.pss+st.ss..................sshpLhpsGs................IPNGshsphPsSs.-cA.sts....s.Ksp.........p.p.sGsRERVRFs-KV.YHuhC..CDsc..s.tpcEht....ct.-..st....sp...p.........................sh.h.ssshshs...pp.p.shssh....Ptps..sTtspsppTl.cKSTpTsl.................	0	2	7	22
+15106	PF15253	STIL_N		SCL-interrupting locus protein N-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q15468	Family	\N	27.00	27.00	28.10	27.40	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	410	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.48	0.70	-5.76	17	97	2012-08-06 14:56:12	2012-08-06 15:56:12	1	3	58	0	54	91	0	313.50	46	33.79	NEW	LWsssPhG-hhh.+lthh.RNs+.Lh..lsEKslRLApRHs+Q......sptpshsCFLlGolhVDpDEEGlolslDRFDPGRE........stt.t+hPss.LPGDhllPChl.tpshusspsl.sHsspDhstsFpsLQppls.o+psL-hspLl..slRuplpsp-s.Dtl.hshpWuuVThusshcssPV+slPIIPTALARNL.so.hs.lsplpGshKpGaLTMDpTRKLLL.lLESDPKshoLPLVGlWLsGlsHlpoP......VWusCL+ahaSuulp-R...VhS-sspFlllLaslsa..ppPpFYcC.hspsspt..LpaQLl...ospcslpLa.ppVcsspcp.lphE..LSupspsspts......lFpps.tsh..oh........psssppssss.phssoc...pDSulEDcDlSPR.......P.PoPHPssQpssplhPpVPELSllhDssFhs	.......................................LWsshPhG-hhhLHlsha..RsP+...Lh..lsEKslRLAhRHA+Q.......s.cps.sCFLLGolhlDpDEEu.....lolslDRFDPGRE........sts.thsPss.L.PGDhllPChlphpt.sspphh.scssp-hstshpsLpppls.u+p.l-hsphh..th+sphh.pp...t.h.hphphtuVs.usshchsPl+slPlls.TALARsL.so.h........s.luplpGshKhGaLTMDpTRKLLL.LLESDPKshoLPLVGlWLuG.lh..HlhoPp.............VWAsCLRYhasuulp-R....Vho-sGsFlllLashT+..pp......PpFYcC.hsppsp...hpaQLl...osppslpLa.ppVcssppp.lphE..Lospspshpsp......hFpph.psh..sh........ppsspp.sss.phshpc...psSslEDEDhSPR.......P.PsPHsssQphptl.sphscLulhhs.ph..t..................................................................................................	0	17	20	34
+15107	PF15254	CCDC14		Coiled-coil domain-containing protein 14	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q49A88	Family	This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.	27.00	27.00	28.40	28.30	21.10	25.90	hmmbuild  -o /dev/null HMM SEED	861	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.69	0.70	-13.43	0.70	-6.17	11	77	2012-08-06 15:03:12	2012-08-06 16:03:12	1	3	40	0	44	93	0	449.60	39	86.45	NEW	DSESQs-sVp.GLDGCASLL+DIL+NEDo..GsEhsaScs......Rssu+PLEuKtst.KKKG.cK+hsPshVpKEILSSssKK.IsN-uSsusc+DsSsltQpWSLQDH...Yph..YSPlIYQALCEHVQTQMSLMNshuSKsssNGIPslPCH..ssSsu-oQu.ostSsYGLsTSssVhSPQpPsCP.hVHSEV....QTsu-sQhuSQspssSVsss.slspsshsspPulsC.uLPtsspsAlPshptLshsstlhP.Q...pphsKEsDLLKChQTahuLhpuH......s..hpsDsQsppSsophQsu.hlAosEEcsAcEpIt-ssSEtc-LN.hpltDuchsKslQ........KucNlscTAcKV+hlKYLLGELKALVs-QEDSElpRLlTElEAClSlLPAVuGsTNlQVEIALAhQPLRSENAQL.R.RQLRILNQQLREQEKTcKsoGsh-CNLELhSLQSLNhSLQsQLpESLKSQELLQSKNEELLKVIENQK-ENK+asslFKEK-QTLLENKQQFDIEhT+lKIELEEALsNhKohQFKLEoAEKENQILGITLRQRDAEVsRLRELTRTLQsSMAKLLSDLShDoARsKstssLTKSLLNIY-KQLQcDPsPupTS..IMSYLsKLEss+oh.sHuEsl.shcscEshtPs+.YEssLsScsPp...pusststEEhSAstllsshSKp-SDp-SEohTLlE-csNL.DpTlYIPFARSTSKK+SsLScR.......lSPQPQhsVAssQLssssGl.sSc+Es+hssPsVCSuppp-u...E-uspcLuRsu-hEDcQLLcKIKEsIsKIPsuh.......................-c.c-puspHuPuApppsslplK..GssVsDuSFLNSDLM...SDWSlSSFSTFTSRDEQDFRNGLAALDANIARLQKSL+oGLLcK	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..-.s.Lh..+.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	11	13	23
+15108	PF15255	CAP-ZIP_m		WASH complex subunit CAP-Z interacting, central region	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5SRD0	Family	This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.	27.00	27.00	27.60	27.40	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.75	0.71	-4.25	19	184	2012-08-06 15:04:32	2012-08-06 16:04:32	1	4	61	0	91	153	0	131.50	38	14.78	NEW	PhKsKEPS.oRIGKlQANLAINPAALLPGAsPpluGsKslhPthuhssucPstspuscssss.stsuuEtGVSFDtPAQADTLaSANKoRlKhpGKRRPQoRAAR+LAAQ-SsEs..--sssscss..s.htpsssssssppP	................................................sS.shItK.lQ.A.NLAlsPAALLPu..A...u..Pp.sslKssls.hs....P....sSpss...tu.ts.........hsh....s.........tutEsuVSF.D.Ps.p.u...s.TLp.S.s.N.K...sRs+hpuKRRP.oRtuRR.Au.pcSsts.....pshs.scts.....................................................................	0	16	23	45
+15109	PF15256	SPATIAL		SPATIAL	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q53FE4	Family	SPATIAL (stromal protein associated with thymii and lymph node) proteins may be involved in spermatid differentiation [1].	27.00	27.00	48.40	28.50	24.20	26.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.56	0.71	-4.24	23	106	2012-08-06 15:09:08	2012-08-06 16:09:08	1	2	40	0	49	103	0	171.60	38	56.60	NEW	FFSRHsPHP+RVsHIpGLNGhPICsVsD-..............shh..p..hP.sth....ssshhthP...hs.lus........PRsspcP.h.........psW+cEL+-huSclslshKcpEhKsKc...................p.s.YSspTGRlhPsuopusoccssp.t.+schptpsh..phssa.DQElhILEhLCQILpTDSLutlQpWLLpAusK..EK-LV.uLlpoAlA	..................................................FhsRHpPHPp+VsHIpsLssh..PlCsVpDc..............s.h......lP.uph....Sts.ht.Pshsls.lus...........PpssppP..........................pthp+EhhchuScsshhhK.cpEhKsKc....................................................sspss+hhss...ssps.uchpop.......pspsptps...ph..h.DQElhlLthLCpILpTDSLstl..WLL.AssK..EK-hs.uLlpstlu...............................	0	11	13	19
+15110	PF15257	DUF4590		Domain of unknown function (DUF4590)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q5RHP9	Family	This family of proteins remains to be characterised and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.	27.00	27.00	35.50	34.40	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.57	0.71	-4.28	11	71	2012-08-06 15:24:02	2012-08-06 16:24:02	1	3	46	0	40	56	0	114.30	64	13.59	NEW	VHLuac....DhRDEIKVYQQHCGGENLCVa+G+.LLEsETFpFlS+RHhGFPFSLTFaLNGlQV-RLSSCCEYKH...++GSRLGG..+pGaFGFlsVEGASPCY+C.Il.........uhG.LDKKPpPPh++	...................................VHLupDp...DaRDEIKVYQQHCGGENLCVYKG.....K.LLEp...ETFQ..FISKRH+GFPFSLTFFLNGhQVsRLSSCCEYKH...RKGSRLGG..K+GYFGFVsVEtuSPCY+C.II.........AMG.LDKKsosPp..c.............	0	14	16	22
+15111	PF15258	FAM222A		Protein family of FAM222A	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q5U5X8	Family	This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.	27.00	27.00	93.40	51.40	20.70	24.70	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-13.00	0.70	-5.28	19	161	2012-08-06 15:29:42	2012-08-06 16:29:42	1	3	37	0	87	116	0	305.50	34	95.79	NEW	KWDTTQ+MRS....ApYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHlRRTVNGLDT..SGQRYSPYP.sQuuu+sGLLAIVK.............sP.sKGllK-h-GsR..sRLh..scuhMNPssuPY..susSTLs......H....Pt......tl.h..Qt..............HsQ.............................oLtp...................................................h.H......sQuh.p...............................................................p..shtp.ps.st........t................h..GuRKhPDuD..AP.PNVT..VSTSTIPLSMAAsLpQ...sc.sDLuSIVHQINQaCQARA.GhusTShC.EGQIANPSPISRNLLIsAsoRVSsHs......sss...suC.hlss.-p...u.AslPsust.s.s.hshsthssuY.s..p.....................sWsQH....QLsahQphspsut.........sppsthctstspsFss+s..sYP.chs.huQsaslKs...sh-+ssPSsPV..Ns..ushs......YsNGpYap..PhWssI....LsTPsSDuuGu.QDLshsFpGutsuuss.................................................ssGs+YRhusuu...su.....QsshMQohDYLu.GDFQ..PCF+-QshuhhtKhp.....R.sshs+ss.-sscupshHIQHPGYR	.........................................................s.aPosApLDAaAp+sAppPLoIpIFPssl+VPQ+pplpRTVNGhDT..os.RaSPYs..psss.tGLLAll+..................ss..sKullKs.cGtR..s+h.....s..p...ssY..s..sshs.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sPh..ss............hssGpYht..s..stl.....sssssss.ss...h..hs................................................t...t...............sp.hpsh-hh..t-hp..s.hp-p.h............c......h........t...t...p...............................................................................	0	3	13	41
+15112	PF15259	GTSE1_N		G-2 and S-phase expressed 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NYZ3	Family	This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localised to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis.  This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.	27.00	27.00	30.30	29.20	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.99	0.71	-4.23	25	105	2012-08-06 15:40:42	2012-08-06 16:40:42	1	1	43	0	46	87	0	128.60	40	24.70	NEW	DlhLLsDEKFDFDLSLS............su...........Susc.....DDEVFhGPVGHKERClAssl.....st..stts..sstssphoWSPLsGEKFsElaKEAHhLALQlEssu+sptspssp.....ptstspssEpFlp-octKlslhppppchcpSPhslKRETasl........p-S	.....DlhhlsDEphDFs.lsLSso...................supE....pDspVhhuPht.hcRslutth.....sp...sptss.sspss+hohuPLosEKh.ElhcEAphLAhQlEpsuhpcpppusp...............h.pt.t.plsh..t.pchp.SP...+RETahlp-..........................	0	5	7	17
+15113	PF15260	FAM219A		Protein family FAM219A	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q5XKK7	Family	This protein family, FAM219A is a domain of unknown function. This protein family has been found in eukaryotes. Proteins in this family are typically between 144 and 191 amino acids in length. There are two conserved sequence motifs: QLL and LDE.	27.00	27.00	30.30	29.00	25.80	23.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.09	0.71	-3.78	11	124	2012-08-06 15:42:48	2012-08-06 16:42:48	1	2	49	0	67	112	0	120.40	62	71.42	NEW	QK+R-hAR+uL+K+Gh..GsslspQP+pss+....R.oV+aNKGYsuLSQ.os-Es.LVoLDSD.SDsEl-.ppa.SSGYSSA....QVspDLo...+QLLpDGY+LDEIPDDEDLDLIPPKsluossCsC.....s-ssSCslQ	.................................................................................pKpR-LARpu.h+pGsh.GuslspQP+pssh.....R....Vh..NKGYouLsQ.SPDEp.LVuLDoD..SD--h-.S......RY.SSGYSSA.........EQlNQDLs...hQLLpDGY+LDEIP......DDEDLDLI.PPKshsso...shsCp...hssSouCplQ...........	0	11	15	32
+15114	PF15261	DUF4591		Domain of unknown function (DUF4591)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6NUN7	Family	This protein family is a domain of unknown function. It is found in eukaryotes, and is approximately 120 amino acids in length. In humans, the gene encoding this protein lies in the position chromosome 11 open reading frame 63.	27.00	27.00	29.30	27.40	25.80	26.80	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.24	0.71	-3.90	15	75	2012-08-06 15:52:54	2012-08-06 16:52:54	1	2	55	0	47	70	0	117.60	37	20.44	NEW	KLGGLGPDh.-uh+s..KhpKLppQKEYA+plKEaNhKsluh..h.ppspss+s-scssls+....+K.ALEYAKoIPKPK...stp...................sQtsKc...tpp..s..stppsslPcIohLEhLpsRHE+EKpsVAAFKsLHIl	................+LGGLGPDh.ps.c...KhpKlhpQKEYAcpl+EhNh+slsh..p...pst+spspsslsc....p+.ALEYAKsIPKP.K...ssp.s...........................................cpssKc....ppp..p...stc-tshsclo.hLEhLpsRHE+EKpsVAuh+hhhh.....................................	0	19	24	29
+15115	PF15262	DUF4592		Domain of unknown function (DUF4592)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6NV74	Family	This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.	27.00	27.00	28.10	28.40	26.80	26.60	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.64	0.71	-3.60	27	118	2012-08-06 16:00:45	2012-08-06 17:00:45	1	2	40	0	57	103	0	116.20	39	13.35	NEW	tpsI+hGps....Ph.hptpc.psussssE-DslPpSP.Ehss.p-sh.ssspppsssh.t.pp....stsupp.p..pssss+sspshps................suuo..slshsusspshupLDNSAA+HKLulKP+pQRsup+	........................................pNlKhG.s....Ps.s.lshK+sp....susso.E-DhlspSP.Ehsh.p-lh.usspppsss.s.sp.p....st.tsc.p..tssss+sSps.t.hu..............suush.slshsssPpu.upLDNSAAKHKLuVKP+pQRsS+...............	0	5	13	25
+15116	PF15263	DUF4593		Domain of unknown function (DUF4593)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6ZR54	Family	This protein family is a putative uncharacterised protein family. Its existence is uncertain and its precise function is unknown. This family of proteins is thought to be found in eukaryotes. Proteins in this family are estimated to be around 155 amino acids in length.	27.00	27.00	279.40	279.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-10.97	0.71	-4.33	2	2	2012-08-06 16:06:49	2012-08-06 17:06:49	1	1	2	0	2	1	0	155.50	50	89.11	NEW	GpLLushGPSTlPhh.suGuCpPpPLuPGGppPPPPPRAHhuP.EAs.utsPus..LPPTRGl.hKsh.opsuPshpLGGPGLPG+uGPCGPRupPsQs.uGptsssGtGspoPhhTLPCSlstSptlh+GRSHLttsLuslGEARGshAhhsWGQ	GpLLushGPSTlPhh.suGuCpPpPLuPGGppPPPPPRAHhuP.EAs.utsPus..LPPTRGl.hKsh.opsuPshpLGGPGLPG+uGPCGPRupPsQs.uGptsssGtGspoPhhTLPCSlstSptlh+GRSHLttsLuslGEARGshAhhsWGQ	0	1	1	1
+15117	PF15264	TSSC4		Tumour suppressing sub-chromosomal transferable candidate 4	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9Y5U2	Family	This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted [1,2]. This same cluster is associated with the Beckwith-Wiedermann syndrome [3].  This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.	27.00	27.00	28.20	27.30	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-11.01	0.71	-3.64	50	121	2012-08-06 16:07:49	2012-08-06 17:07:49	1	2	89	0	70	104	0	142.80	25	47.58	NEW	pculFssL-sspc.....................hsssshsp...sssps......................................................puhFK+P.sPssp..............................................hphsplPDYh.tcP-+WTKYSL-D..Vs.p..hS....-poNpAAAluFLtphctp+t............s..sshsp-sssssp...............s+	..........................................................................................pslFspLpsstp.........................sh.p......sp..p.................................................puhFc+P.sPssp.s..........................................sps.slPDYl.tpPc+WT+YSL-D...Vsc..sS..........-poNptAAhuFLpphppppt.................tph.sp.p.........tth....................................................................	0	22	36	54
+15118	PF15265	FAM196	FAM186A;	FAM196 family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6ZSG2	Family	This protein family is a domain of unknown function.  This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.	27.00	27.00	62.30	52.30	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-13.01	0.70	-5.26	27	99	2012-09-25 05:53:12	2012-08-06 17:11:43	1	2	35	0	61	62	0	405.70	40	97.84	NEW	Msp+............ps-scPsh..........h+.uLDssctlK....+RNKu.QVRFKD.spuQNppt.spls.p....st+-upshssK.tA.R+ahsss.sppSlPpspK.....ShulQTSPsL+K+a.oF..cRKK...upsl+phssssshptQsNGhLs-tc.ht...p.ht.st....-uscpst.spshtsps.hhpSstshsht............h.sutpsosuspsP-...pSss.p...sh.ssspssttpsph.......hhstsptcttth.sp-...tsssshsps.t...........ppssplhhPpssspsspssh.s...spscpstsPusspp+pps.s.Ls..shpp.shsttsu.Css.s....pshoscs.ust..shps..............ps...tp.....t..ss........tostthpptsQphls+sE.lsDLpupLQshEphlpSsQEpIKVLLsVIQ-LEKucAhpEGho.YRTGQDhsNCsTCpNoACIIYSVEhDF+QQ..EsKhpsV..L+pLc.shEpsphss.PhppEshsssPcpKoKscp..KKctRhphWaL	.......................................................................................................spp.............p.cscPsh.........h+.uL-ssc.lK....+RsKu.QVRFK-.spupN.pt.tplsst.....ttc-stsh.h+.tA.R+ahsss.hphShPpspK.....shulQTSPsL+Kpa.sF..cRKK.......up.lhphsssps.t.QsNG.L.-.c.h.......t..t....-u..pst.stshhsph.hhpost.hshh.......ss.pssts.hpsP-....u.s.t....h.p.sps..st.psph.......h.shs.tc..ttt..spp....sssshtth.t...........................pthsplhhP..t.ssps.t.s..s...stsc..hsPus.pp+pps...hsuhp..t.s.st..t.Css...s....phho.psspt..s..s...............p.............................ss.............sshth.st...sp.hl...spsE.lsDLpupLQ.hEp.lpSsQEpIKVLLsVIQ-LEKucAhpEGhs.YRTGQDhsNCsTCpNoACIIYS.VEhDF+QQ..Es+hp.l..LppLc..hE...sp..s.P.p...t.s..sssP..cp..pshpcp..KKht+hphWal..........................................	0	4	12	25
+15119	PF15266	DUF4594		Domain of unknown function (DUF4594)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6ZUT6	Family	This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.	27.00	27.00	35.30	35.30	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.63	0.71	-4.14	14	111	2012-08-06 16:19:33	2012-08-06 17:19:33	1	2	45	0	55	87	0	163.10	40	33.26	NEW	Ps.pscssRpEGScctsRNWuGssacsV+phs-pp+.c..utRss........stsshDhshuhotpEptEYlRWKpEREQIDpERLARHRsupGpWRRtWDh-Ks-sMh+-ssp.tsptsshstpptt.....cc.p+PPpsPshts.h.pstp.upsp.pstspS+upGpph.......ot+ccRWEtcp-.tpc.p	...........................Ph..scpptpEGSptpsp.shusss.ptlp...-pp+....GtRts..............tssschsh.uh..s.sccptEYhpWKQEREpIDp-RLARHRcupGpWRRtWDh-K...s...csh.hpDs.st.t...tcss....pchss.............ptht.PPhsPshtt...hhspttttspsp.t..ttpS+spu+tt.......os+scRW-h+Et.t...tt................................................................	0	5	8	21
+15121	PF15268	Dapper		Dapper	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5SW24	Family	This is a family of signalling proteins [1-2]. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers [3].	27.00	27.00	27.10	27.10	20.30	24.60	hmmbuild  -o /dev/null HMM SEED	748	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.49	0.70	-5.74	24	169	2012-08-09 10:45:45	2012-08-09 11:45:45	1	4	40	0	81	188	0	446.60	32	88.35	NEW	ERLcAsLAGLpELphLRpRQphhVpusLt.....s..ss.hs.....................hpEphLEtslhsL+cQL.....spLRRpDsGLhspLppLDpQIS-L+LD....VcKsopEtL-oDSRPSSGFYELSDGuSsSLSNSssSVaSEslSS.........hhsusph....csphshuDsRP+S.AD................s............................hGpL-p.h.upst.ppsut.c.p.ss.hspuhcl.sc.lcPKYQs.DLVSKsGp-VY.YPSPLHAVAlQS..PhFhLsh..........Ep.tsssp..ssttst.sss..sssh.p....hsssh.sss..hcuYI.pLLQ+ppptspss+spsu.pus...thhtt.......sss..tpupsss.csptphss.ssGtsshs.....ushpphstcppu.p.pstt...........ssssp.pssshscptspssspphttps.sss...........................psp..ssssptp..pssh................ppspshtP.ppls.ps.........................................s..t.G..thVpupalsu.psp.s+l+p.GsppsKssK.+ppsopKstt.utpt..ts.pp.Rp...............+spthsphsRhP....o.tppspt..pSspppp.hssshh.shlsuR..u....uptpuh..hcutshu.ts..uts++Kp....RRW........................pSosEIShcpt.pp..............s.RRstt.ph..uhhts.hsh..sps.h..u.S-...SEYSAECtSLFHSTls-TSED..EpSsaTTNsFGDSESShS-s-hsspSosoS.o............-uusLlWsphs.t...shp.sssuu.....c.t.sPs.phs+IKAS+sLKKKIhRFpsuSLKlMThV	........................................................................................................................................ptL.....GL...l.pLs.Ql.scLpL-.........tt....h-p-St.SSGFY-.ssususs.t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................aG-tESS.up.p.s..........................t....hs................................hhs+IKAS+sLKKKIhRFpssuLKlMThV........................................................................................................................................................................	0	5	15	30
+15122	PF15269	zf-C2H2_7		Zinc-finger	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q32MQ0	Domain	this is a family of eukaryotic zinc-fingers.	27.00	27.00	27.00	117.80	26.90	20.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.90	0.72	-4.10	2	69	2012-10-03 11:22:52	2012-08-09 12:40:46	1	2	37	0	49	53	0	54.00	86	8.43	NEW	ptRKPKKPHYIPRP.GKPapYpCFQCPFTC..KSHLaNHMKYsLCKNSlSLl.p	..KERKPKKPHYIPRP.GKPapYKCFQCPFTC.EKSHLaNHMKYuLCKNSloLl.p.	0	2	6	19
+15123	PF15270	ACI44		Metallo-carboxypeptidase inhibitor 	Coggill P	pcc	Pfam-B_261362 (release 26.0)	Family	ACI44, a metallo-carboxypeptidase inhibitor, is one member of a battery of selective inhibitors protecting roundworms of the genus Ascaris, common parasites of the human gastrointestinal tract, from host enzymes and the immune system [1].	27.00	27.00	28.10	154.10	26.50	18.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.37	0.72	-3.99	3	3	2012-08-09 11:46:34	2012-08-09 12:46:34	1	1	1	1	0	4	0	64.70	93	86.22	NEW	DQVRKCLSDTDCTNGEKCVQKNKICSTIVEIQRCEKEHFTIPCKSNNDCQVWAHEKICNKGCCWD	DQVRKCLSDTDCTNGEKCVQKNKICSTIVEIQRCEKEHFTIPCKSNNDCQVWAHEKICNKGCCWD	0	0	0	0
+15124	PF15271	BBP1_N		Spindle pole body component BBP1, Mps2-binding protein	Wood V, Coggill P	pcc	Pfam-B_31027 (release 26.0)	Family	This N-terminal domain of BBP1, a spindle pole body component, interacts directly, though transiently, with the polo-box domain of Cdc5p. full length BBP1 localises at the cytoplasmic side of the central plaque periphery of the spindle pole body (SPB) and plays an important role in inserting a duplication plaque into the nuclear envelope and assembling a functional inner plaque [1]. Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge [2].	20.00	20.00	27.20	66.80	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.02	0.71	-3.83	14	27	2012-08-09 11:50:23	2012-08-09 12:50:23	1	2	27	0	16	22	0	154.40	47	40.10	NEW	sus.sGla+WThDALFGs+lSPSpKY.+-.........auQDDTNYphpt............pstps+oR.SsSWss............DssFhc+YDLLssppppshp................................................ptLhsPlclhsp.............................s..pcsTDTFup+............t.pphsstph.hcsPptD....DsllS+LFt+t	.....u.GGhhGLFKWThDALFGoclSPShKY.K-.........aAQDDTNash+hspsp.......s+pssshSRSNSWSGl...........DSoha+KY-LLP-hsEsshs........................................s.cspcclcSLhSPsslsPR............................pPhps-PTDTFupR.........pRpshschussplsFhsPpcD....DPLlSKLFsK...........	1	2	7	13
+15125	PF15272	BBP1_C		Spindle pole body component BBP1, C-terminal	Wood V, Coggill P	pcc	Pfam-B_58229 (release 26.0)	Domain	This C-terminal domain of BBP1, a spindle pole body component, carries coiled-coils that are necessary for the localisation of BBP1 to the spindle pole body (SPB) [1]. Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge [2]	22.90	22.90	22.90	22.90	22.40	21.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.38	0.71	-4.75	12	35	2012-08-09 11:51:47	2012-08-09 12:51:47	1	3	34	0	23	31	1	176.50	32	43.31	NEW	c-aos-YlcLLDpLspNs+pLcpLpp-lcp+ppchpppEpoY+pKYhphRtELIpELKQSK+laDNYacLapKYppLKc........hspcs.chppplssL-splVppslpKs+chpphpcclhplcl+tpchp.t+ch-thtYEoRIc-LEppL...pNp.ptpshhup.s.os........s.............p.hpc.N.solDopFlcpls	..........t.capptYhcLhsphshNs+sLccLsc..-lcppccphccpE.....poY+pcYpphRsELlsELK+SKpLa-NYYpLhpKY+sLK+.............................shcpshshpsclu..s.cccLhpcts.KshcIpsLp.pcL...shcl+hppLp.t+p...hpc...sYEScIcDL.hpLp..pss.ptssshsophhSs........s.................c.s.tshssph.cp..............................................	0	4	12	20
+15126	PF15273	NHS		NHS-like	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5SYE7	Family	This family of proteins includes Nance-Horan syndrome protein (NHS) [1].	27.00	27.00	27.20	27.00	26.00	26.90	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.51	0.70	-5.89	26	237	2012-08-09 11:54:02	2012-08-09 12:54:02	1	3	40	0	110	185	0	389.90	30	41.26	NEW	stp+SpTRDSuCQTE-lhI...ssPShRRIRAQ+GQ.GIAAphSp.o......GNhSl..LoDsusshF.ssphstssp.hpp.LPRpGuRss.ps.pthts......p........phuphps.-shh..tss.R.....tscspEspspput.......suhhhS.Hus...........Pstolsppucshh.+p.tshGps-hpssSsohsSs.hp.psshs..ttth..K-sHpSSSGsW..sposssppo.pohsssuusshssSShsDSplSLNsss.st-ss..........sps.thpsppssSFsSpstD..scspsutossst.s..tspcph..aps.ssttsps..sphssP....uhoossop.Stss.cpsSsKsDosShYSVDs-GYYT.SMHhDsGL+uspph..s...s.s.thttstpsh.shh-httppp.t...htpc+php+sISL+KsKt.PhPPpRosSLR+hsp............Kpp.p.uph.pEshluohppoLQLsL.tpss.....SSsspSssssh-s.hlhpscSposlussSS.hS...........phhShsssossapDsSulpS-YAD.Whh..Dhpusstc.ts.ossuoAoussshp..pustus.sps............SRuosPsl........PSspsc.KluSPEKhttLsSPSSGYSSQSpTPTuuhPl...shF.pshs.usGtGKhKPKVPERKSSLhSssphSSSSTSLSSsoSc-	...........................................................................................s....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..........p.p.ht.shSh+KsKh.P.PP.RosSLhc......................................................................................................................asc.Whh..Dhps.p.s.ts...sssssssus.ssht..ps..pp.p.s............sRss.Pp.........uh.psc..+.hsSPt.+.ttlhSPSSGYSSQSpTPTs.hsh...sh.h..t..s....ssu....ts+.+PhVPERKSSL............................................................	0	4	14	43
+15127	PF15274	MLIP		Muscular LMNA-interacting protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VWP3	Family	MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localises with lamin A and C in the nuclear envelope. MLIP also co-localises with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP [1].	27.00	27.00	81.60	48.00	21.30	25.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.66	0.70	-4.89	2	110	2012-08-09 12:06:34	2012-08-09 13:06:34	1	3	32	0	43	83	0	137.00	44	42.14	NEW	ptMQQSDLFKAEYVhIVDSEGE-EAsuRK.-ptPssG.GpuhsRPKSLAlusu.losl.+P+..tsDhpsssps-h.pshAs.QKphQQYKhKSSYKAFAAIPTNTLLLEQKALDEPuKoEploKDsTL-s.lEhh.PAQLRQQTEELCAsIDKVLQ-SLSMHSSDSPSpS.pThLGSDssKhPsTlPRAAGRETKYANLoSPSSThu.SQLTKPGVIRPVPsKS+IlL+KE.EEsYEPNPFSKYLEDsSsLFutQD	.........................................................................................................s.h.t...P........p.t..s.st.h..uhus.ppK+sp.......................................................................................................................................................................................................................................	0	2	4	10
+15128	PF15275	PEHE		PEHE domain	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q68DK7	Family	This domain was first identified in drosophila MSL1 (male-specific lethal 1) [1]. In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3) [2-3].	27.00	27.00	27.00	27.00	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.04	0.71	-3.67	27	274	2012-08-09 12:08:56	2012-08-09 13:08:56	1	2	88	5	145	277	2	121.70	32	15.40	NEW	lhsP..sWRsl..slpshsssp...t.t.........hEsLSDpsFspRHpKYE..EpERpRWshhp.pc.pRppp...Rphpcs.............s.sp.ss.shsp..............sps.psschsscsss.shtcsh...lptsp-...................hslPW	........................lhsP..oWRts....slpslcsps.......st-................................hEsLSDssFstRHtKhE..Ep-R..p.....RWsh.pp..pc....p+hpp.....R.hcpp.................t..s.p...spsphoo...hs.................psc.s..ts..h..hs.....s..shtps....h..pp...............h...W...........................................................	0	36	50	92
+15129	PF15276	PP1_bind		Protein phosphatase 1 binding	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q69YH5	Family	This domain contains a protein phosphatase 1 (PP1) binding site [1].	27.00	27.00	28.60	32.40	26.40	20.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.19	0.72	-3.95	12	102	2012-08-09 12:15:31	2012-08-09 13:15:31	1	17	45	0	50	96	0	62.80	49	4.09	NEW	tK+KRVoFGtcLSPElFDcsLPsNTPL++GuTPs+ppssts.ssslh.cu......t..c.h.QP..sF-s	.....KRKR.VoFGscLSPElFDEsLPsNTPL++GsTPs++pshsst..o...s...lLcc...........c..sQP...........................	0	10	13	21
+15130	PF15277	Sec3-PIP2_bind		Exocyst complex component SEC3 N-terminal PIP2 binding PH	Wood V, Coggill P	pcc	Jacckhmmer:Q10324	Domain	This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the PIP2 head group are conserved. The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables [1].	25.30	24.10	25.30	24.10	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.09	0.72	-4.12	101	335	2012-08-09 12:23:49	2012-08-09 13:23:49	1	8	228	7	232	344	0	91.70	31	10.66	NEW	pp+Ks.Rhlhlu..lpps.s...lplp...KsKpss........sGs...aplu+oWsLc-Lptl-shsst..................sFslsh.sK.......sYhWpussspE+p.hFlpsLh+lhpca	.......................tcKsphlsls..Vppp...s.........lplp...KsKpss.........sus...aphtcsWtLc-Lptl-uhss................psspFsLph.sK.......sYpWhAsospE+s.tFlpsLh+lhp+Y.............	0	54	101	171
+15131	PF15278	Sec3_C_2		Sec3 exocyst complex subunit	Coggill P	pcc	Jackhmmer:Q10324	Domain	This small Sec3 C-terminal domain family is based around the fission yeast protein, and is rather shorter than the budding yeast/vertebrate domain Sec3_C, family. Pfam:PF09763. In fact it is only this coiled-coil region that they carry in common. The full length fission yeast, UniProtKB:Q10324, protein Sec3 is redundant with Exo70 for viability and for the localisation of other exocyst subunits, suggesting that these components act as exocyst tethers at the plasma membrane. Sec3, Exo70 and Sec5 are transported by the myosin V Myo52 along actin cables. The exocyst holo-complex, including Sec3 and Exo70, is present on exocytic vesicles, which can reach cell poles by either myosin-driven transport or random walk [1].	27.00	27.00	29.40	28.40	25.70	19.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.81	0.72	-3.85	2	2	2012-10-03 17:31:52	2012-08-09 13:28:37	1	1	2	0	2	3	0	86.00	29	14.06	NEW	hp+L.pLcWsttsshccs.pph..ShstuhhpsVEpLhcpchphpplps.LpDshhGC-ol.STlNLaShpLSssLssVINhEQQ.	...hp+L.pLcWsttsshccs.pph..ShstuhhpsVEpLhcpchphpplps.LpDshhGC-ol.STlNLaShpLSssLssVINhEQQ..	0	1	1	2
+15132	PF15279	SOBP		Sine oculis-binding protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9Y5P3	Family	SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif.  SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis [2]. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein [1,2].	27.00	27.00	28.30	27.80	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.80	0.70	-4.04	17	146	2012-08-09 12:36:43	2012-08-09 13:36:43	1	5	65	\N	86	127	0	243.80	35	40.11	NEW	sCDWC+HlRHsssYVDFQDGtpQLQFCSsKCLNQYKMpIFh+ETQAHLsh....sPHl+stupstt.........sLITP-LW......L+sC+SpSsus.sssh..ssussPu.............s.ptSP..............pshlosu.sopLhs.p...st...sss...........................................................................................hshsshss...............hppph.tp.psPhhs.ss..............hs..........psshhs.sPttt.hhpPa.p.ss.......s.PPh.h..ssPtshh..sh.s......Ps..............................lPPVTlLVPYPl..lIPLPlPIPIPlPl	............................................................................................................................................................................................................................................................................................................................................................................................................................................................ts.s.hlhs.sp.u.Ps.lP.hhh...E.....pphhQplp.sPhlh...Pspt.........ssssss.shsN.h.s..........ssss...t.....h..s.ss..p..htPa.tss.......sh..s..Psth.h...s.PP..Pst.....suhs.P.s.s........hP.s....P...........hs.h........................VPPsTlL.VPYPV..IVPLPVPlPIPIPl.............................................................................................	0	14	23	43
+15133	PF15280	BORA_N		Protein aurora borealis N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6PGQ7	Family	This family of proteins is required for the activation of the protein kinase Aurora-A [1].	27.00	27.00	28.00	27.30	22.60	26.20	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.56	0.70	-4.98	25	110	2012-08-09 12:38:03	2012-08-09 13:38:03	1	4	81	0	72	106	0	195.70	37	39.28	NEW	husptps.hphTPpssuh..............plhNPFE.ss.hppL+pshh.SPSlF...poss.........spposspFcWSIDQhAhLtPs-I.Dpc.-hpppuhhh......s.........-hE-+hQpAI-pFF.opssIVPSPW......................................s.thh.pp..hhphs..t.oshspph..p..stppssusQ..TsLoLPssh..-LEclLG.caapspcss..ct.............tt......hosSSLRRKLFhsssss.tsspsssssus	.......................................................thphTPpo.sshh.................lhNPFE..ss.hspLHpthlsSPSlF...+o..............osspFcWSIDplAhlpPs-I..Dsc.-hpppshhh......s.t........-lEcKtQcAI-pFF.scssIVPSPW.........................................ts..hpphh..tshp.....sp...oPhspph...t..spppssssQ..ThLSLPssh..sLEplLu..sYFpsc-hs..-ps.......ts.........lSsSSLRRKLFhsssssh..........ss.....................	0	24	30	53
+15134	PF15281	Consortin_C		Consortin C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6PJW8	Family	Consortin is a trans-Golgi network cargo receptor involved in targeting connexins to the plasma membrane [1].	27.00	27.00	33.00	31.90	23.20	21.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.54	0.71	-4.58	12	60	2012-08-09 12:38:45	2012-08-09 13:38:45	1	3	36	0	31	52	0	109.40	64	19.29	NEW	ElsPupGLVSILKKRpss.Gpp......lsp.ppcpoKRRVRFpEs-DshDQ.DEsuGsSClLLlLLClsTVhlSlGGTALYCThGDhcSsVCpDFusNhDFYhsplhQslpcL+HWls..hS	...............................ElsPsEGLVSILKKRs-olGcp......sAQhQpKsSKRRVRFQEhDDsLDQ..DEVGGGSCILLlLLCIATVFLSlGGTALYCTFGDMESPVCTDFAcNhDFYYT+LLQGhAELKHWIh.lS.......................	0	2	5	12
+15135	PF15282	BMP2K_C		BMP-2-inducible protein kinase C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6ZSR9	Family	This family represents the C-terminus of BMP2K and related proteins [1-2].	27.00	27.00	27.00	54.70	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.76	0.70	-4.17	17	79	2012-08-09 12:40:07	2012-08-09 13:40:07	1	4	35	0	45	64	0	232.80	47	35.62	NEW	tD-hDVFoKAP..........FspKs.............pssstpPcp.sDVFhpuPFp.........................................Kp+ShpcLoshQtpo+p.ssp....u.pphusssss.hs.pPsapo.E+shppptsu.Rsp.SsspFlphos.spcslps..shssups+usshps..............cEshlsPhu.uKPF+PQsLu+aupH.u.pD..................s.shpup.huAa+sssphp.ps.hGuVsh.TsLsspo..........sphsph.DPFuuAPFPSKt	....................--hDVFoKAP..........FspKs.............pshPspPcp.sDlFhpsPFp....................................Kp+SlpcLoutQppo+p.sup.....u.pphGsssssphs.pPsapo.ERAhpppt.stRsp.SospFlphSs.spcslps..sLssupsRGssLps..............cEullsPhu.uKPF+P.sLuhaspH.u.pD..................tpshpsp.huua+sssthp.hsshGuVPh.TpLsspo..........op.spl.DPFGAAPFPSKp..	0	3	5	14
+15136	PF15283	DUF4595		Domain of unknown function (DUF4595) with porin-like fold	Godzik A	adam	JCSG target SP16885A/PDB 4ghb	Domain	Large family of predicted secreted proteins mostly from  CFG group, but also from Burkholderia, Pseudomonas and Streptomyces. Function of these proteins is not known. A 3D structure of a representative of this family from  Bacteroides uniformis was solved by JCSG and deposited to PDB as 4ghb. There is some overlap with RHS-repeat (PF05593) family despite lack of obvious repeats in the structure	23.10	23.10	23.10	23.60	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.42	0.71	-4.65	26	98	2012-10-09 19:20:05	2012-08-14 01:41:03	1	6	71	0	9	96	5	188.50	20	52.61	NEW	apYsspG+lsuhsts.pphsst.p....phpss.sshsYssspl...lh......Tcctssss.....sah..LsppGalppCs.....p..phs....u.....phcsasFoYs.....scspLhplscst.........ss...ht.phslsYpsGslsplppphss.tp..............pshhths.hss..sphss.h.s...hshlhlt..-hhs.lsh...hhhAhYuthLGcssppLsh.phhsc.....ss..p..cspsY..oYshDpcGhsos	............................................hst.splhphh...pp..t........hppp.hsh.sassspl......sh.........ss.cttshh..............shh....LsspGasppss.........phss...........p.csapFoYs.....sps.Lsplpcsh.........ss......hp...phslsYps.Gslsplpsp.ps.p................................p.hhphtYss..sphts..hhp...hshlh....hh...chhs.lsh.....h..uhauth..lG....cssppL.h.p.hsp..................ss......pptpa..oaphcppuhss.......................................................................................................	0	4	8	9
+15137	PF15284	PAGK		Phage-encoded virulence factor	Coggill P	pcc	Pfam-B_45688 (release 26)	Family	PAGK represents a new of virulence factors that is translocated into the host cytoplasm via bacterial outer membrane vesicles (OMV). Members are small proteins composed of ¡­70 amino acids. In Salmonella they are secreted independently of the SPI-2 type-III secretion system, T3SS. The OMV functions as a vehicle for transferring virulence determinants to the cytoplasm of the infected host cell. OMVs are released from the cell envelopes of Gram-negative bacteria and comprise a variety of outer membrane and periplasmic constituents, including proteins, phospholipids, lipopolysaccharides, and DNA [1].	22.80	22.80	23.30	22.80	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.19	0.72	-4.23	3	81	2012-08-20 15:00:40	2012-08-20 16:00:40	1	1	70	0	3	21	0	65.20	61	93.70	NEW	MK+hNSVFLALVLlLSAoTFSALsMAA-SusHph.psIFPh...WCplWPAGIshPE..h.KhCp	........MKKLKEMAAISLFTLLAAGFSASVMADDQA.....P.....ERVPAAEVKPVGE....HVHWCT.LFDPDGMELPPLP......GMEW.....	0	0	0	2
+15138	PF15285	BH3		Beclin-1 BH3 domain, Bcl-2-interacting	Coggill P	pcc	Manual	Domain	The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.	25.50	25.50	25.80	25.50	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.56	0.72	-6.70	0.72	-4.39	8	70	2012-08-31 13:46:58	2012-08-31 14:46:58	1	3	47	9	34	58	0	25.10	89	6.09	NEW	suush-sLS+RLKVTocLFDIMSGQ	...DGGTMENLSRRLK.......VTGDLFDIMSGQ..	0	5	7	15
+15139	PF15286	Bcl-2_3		Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like	Coggill P	pcc	Jackhmmer:P89884	Family	Pfam:PF02180.  Bcl-2_3 is a small family of eukaryotic proteins associated with autophagy. The family is found in association with Pfam:PF00452,	25.00	25.00	25.00	25.00	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.70	0.71	-3.68	3	4	2012-10-03 11:38:54	2012-08-31 17:02:54	1	1	4	5	0	9	0	125.20	59	73.14	NEW	TYWATLITAFLKoVSKVEELDCVDSuVLsDVSKIITLTQEFRoHYDSVY+tDYGPALpNWKssLo+LFTSLFlDsINpGRIVGFFDVGRYVCEELLCP.GSWTE-HDLLN-pMTpFFIENNLMNaFo	...............................TYWATLITAFLKoVSKVEELDCVDSuVLsDVSKIITLTQEFRpHYDSVY+...tDYGPALpNWKpsLo+LFTSLFlDsINpGRIVGFFDVGRYVCEElLCP.GSWTE-H-LLN-pMTpFFIENNLMNaFs.............................	0	0	0	0
+15140	PF15287	KRBA1		KRBA1 family repeat	Coggill P	pcc	Jackhmmer:A5PL33	Repeat	KRBA1 is a short repeating motif found in mammalian proteins. It is characterised by a highly conserved sequence of residues, SSPLxxLxxCLK.  The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins.	27.00	0.10	51.90	0.30	17.70	0.00	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.11	0.72	-4.60	21	189	2012-09-03 08:46:19	2012-09-03 09:46:19	1	6	22	0	74	223	0	44.00	32	25.27	NEW	Gshup...u...sSs.u.SSPLQGL.sCLK-I.lsG..Pp..pPps.....sss..hsPtP	....................tp...u...sss.u.sSPLpGL.sCLK-Issst...Pp..tsps.........ss..........................	0	6	6	9
+15141	PF15288	zf-CCHC_6		Zinc knuckle	Coggill P	pcc	Jackhmmer:A6NNH2	Domain	This Zinc knuckle is found in FAM90A mammalian proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.38	0.72	-4.28	25	289	2012-10-03 11:39:54	2012-09-03 09:47:41	1	25	154	0	191	274	0	37.10	43	3.39	NEW	RVKCKsCGAFGHpu+SpRCPhKp..WpusLsPQslGs+c..tKE	..+lKCssCGAhGHh+TsKtCPlhp..tp..ss.ss.shu.pp..pE....................	0	65	91	131
+15142	PF15289	RFXA_RFXANK_bdg		Regulatory factor X-associated C-terminal binding domain	Coggill P	pcc	Jackhmmer:O00287	Domain	This C-terminal domain of Regulatory factor X-associated protein binds to RFXANK [1,2], the Ankyrin-repeat regulatory factor X proteins. RFXA is part of the RFX complex, Mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes [3].	26.10	26.10	26.70	26.70	24.70	25.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.75	0.71	-3.93	7	62	2012-09-03 08:49:35	2012-09-03 09:49:35	1	1	48	1	31	50	0	118.50	71	58.86	NEW	oCTYpGCsETooQsAKQRK.PWMCK+HRNKM.YKDKYK.KKKsDQAhussuh.................hp-....ss-sslSlsKQRsGuhG-RPARPTLLEQVLNpKRLSLLRSPpVlpFLQpQQphLopQshtQppQphpG	.......................................................................oCTYEGCpETToQVA...KQRK.PWMCKKHRNKM..YKDKYK.KKKSDQAlssuGsus........................usss.s+hEESsDshl............SlsKQRTGShG.DRPARPTLLEQVLNQKRL.SLLRSPEVVQFLQKQQQLLNQQVLEQRQQQFs.G................	0	5	8	14
+15143	PF15290	Syntaphilin		Golgi-localised syntaxin-1-binding clamp	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O15079	Family	Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.	25.00	25.00	25.60	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.28	0.70	-4.93	19	130	2012-09-03 08:50:22	2012-09-03 09:50:22	1	3	41	0	54	139	0	285.30	55	52.53	NEW	+sssuPsss+cs..YGsoS.s.....SSSNSuShKGSDoSP.phpRssRYpoCGDNHGI+PPsPEQYLTPLQQKEVsIRHL+sKLKESpspLp-..REoEIcELKoQLuRMREDWIEEECHRVEAQLALKEARKEIKQLKQVlETM+sSLs-K.....DKGIQKYFlDINIQN+KLEoLLpSMElAQsGs.hpDEssh-hhC..sSPu+oLs.SsshsKlu-.........uhtht-Q..usEc..huDSGlLssD-h...sspsDlhpp..hhos...sssc...........sssulhpstsh.st..ps..h.th..........ptsh........h.pEpulQTDs......lshSsDlcsll..plhp	.............Rpp.sPlsh+su..YusS.S.s.....SSSN.SGShKGSDsSP.......hhRRS...............s+YhsCu-NHGl+PPsPEQYLTPLQQKEVslRHLKs+LKEopcRLp-..R-oEIs-LKoQLuRMpEDWIEEECHRVEAQLALKEARKEIKQLKQVIETh+ssLh..DK.....DKGlQKYFVDINIQNKKLEoL.LpSMEhApsGs.h+-Ehsh..........-........ss.sSPt+SLshusshs+huD...........shshpppssE-..sADSthlssDsh...sstsDlh-p..hlou...sss-...........phpLhpohshssh..h.t..sh.hh.....................t.psus............h..EpAlQTDh......V.YsPslspllpplh.........................................................................................................................................................	0	2	7	21
+15144	PF15291	Dermcidin		Dermcidin, antibiotic peptide	Coggill P	pcc	Jackhmmer:P81605	Domain	Dermcidin is a family of peptides produced in the sweat to protect against pathogenic Gram-positive bacteria.	22.00	22.00	22.00	23.20	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.34	0.72	-3.81	2	11	2012-09-03 08:51:23	2012-09-03 09:51:23	1	1	10	1	2	10	0	94.50	73	82.66	NEW	AYDsEAASAsGSGNPs+EASAAQcENAGEDPtLARQAPKPRKQRSSLLtKuLcstcKulsGLtpLGK-AV-sLEssGKGt..........Vp.sp.sLsSV	...................................AYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAlGGLGpLGKDAVEDLESVGKGA...........VHDVKDlLsSV................	0	2	2	2
+15145	PF15292	Treslin_N		Treslin N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z2Z1	Family	This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation [1-2].	27.00	27.00	29.80	29.80	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	803	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.59	0.70	-13.42	0.70	-6.67	11	59	2012-09-03 08:52:17	2012-09-03 09:52:17	1	3	43	0	36	60	0	621.90	46	46.02	NEW	LYWVDTTEhuKLh-SPDHhGYWTlsELLpplGGTlLPsEohstshscstpslhssshcho....spPpLSsW.....hosLPhDSoLNsLLhssscYcAoFPphEGsLFLslctGKc.Q....cossVTLEPLuMpQRphppPVpI.hLKGoVsp......WshPtuuoLGT-SWlLpSs.-p.spssp.....phLFQQLspcLssEcLHLVA-Vsss-uhPPhTGllSPLSsoAslLTVhpsccs.EhQcahLQssssE.sspDssshhsDlVpsVLsplcsu.....-sssss....ssPVPEWsQQEL.....uRTs.PWosAVlE+W.FPhSNlSGASSsLMESFhLLQAsSss.cEEuS+oEuELT+pLSEhYQRKScE-us.susQc-s+KKRG.lPRTPVRQKMpTM....sRSLcMLNVARL...NVKAQKLpPDGuPssu.uEKuhQKssttRosDKlEs+GRsL+SSKsp-FKTEEELLSaI+ENYQKsVusG.-hhLhoCApshloTIKtFLKSpsTK-lEhsC..lsplKspLLKTSKsLRQp.lGpc..hDKEsKVRECQLQVFLRLEMClQCPSlppssD-hEQlVEEVT.-LLRhlsLTEDsuYLucFL.EEILpLYIsSIPcTL.......GsLYpSLGh.IPpKLAsVLPsDFFSDDSMTQEscSPh.shshsSs.sppulssuoEoDQLEELRTRSAKKRRKNALtR...H+SluEsSQNLRQIElPKVuKRss+pE.NS+ss......QQ..PhPpK-sVQEVTKVRRNLFNQEhlSPSKRshK+.hPRS+SVSAVEGLcaK.tphp+s+spth..sa+KLLTKpVuETPlHKQlS+.RLLHRQIKGRSSDPGPDIsVVEESPEKs	.....................haWlDotp..phhtssDHhGa.ph.clLt.hGGsllP..sh...hsp.h..................t.s.......hp.lPh-uslsh.Lh.ps..aptsFP.hpGhLhhsht.sp.......pshsVhLEPlshpQ+.h.psVpl.hL+Gshtp......hshs..sthso-oW..hLpss.tt.ttttp.....t.hFQpLhppLsscplahlupVs...uhsshTullSPlSssshlLTlhpsc.s.thpthhhpsshsp.ssp-s..ss.hs-llsslLs.h.p....psssss....sssVPEWsQQEL.....upst.saosullEpW.FPhSshSGuSSsLMESFhLLpAsstp..p...-..-sScs-sELhptLuEhYQppsp-pss...ttpcppKKRG.lPRTPVRQKMpTM....sRS.LpMLNVARL...NVKAQKhpPDussssu.spKshp+hsttRss-+hcs+u+hh+o.ut.t-F+o.EEELLSa.lpcsYQKsVust..-hhL.ssApshlSslKhFLKScssc-lEhsC.......lspl+.spLLKTSKuLRQphupc...hDc...EsKVRECQLQVaLRLEhChQsPSlpps.--hEplVEEVs.-LLRhls..LTcD...suYLucFL.EEILtlYlsSIP+sL.......GplYpSLGh.lPpc....LAuVLPsDFFSDDShop-shSP....s..Ss.sppusssuscuDpLpELRsRSA+K......R.R.pssLhR...H+SlsEsSQsLRQIElP.......KhoKRs.s+pc.sspss.......................p.s.shKpslQEVTKVRRNL..FN..QEhhSPSKRuh+p.hPRS+SVSAlEGLcp.K......hsp.tp...t.sh++LLT+pVsETPhHKQlSp.RLLp+QhhGR.p.Ssss.-htlVEESP.K.s.......................	0	5	8	17
+15146	PF15293	NUFIP2		Nuclear fragile X mental retardation-interacting protein 2	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z417	Family	\N	27.00	27.00	34.40	34.30	20.90	23.00	hmmbuild  -o /dev/null HMM SEED	599	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-13.23	0.70	-5.79	8	69	2012-09-03 08:53:03	2012-09-03 09:53:03	1	2	37	0	43	47	0	452.40	49	85.05	NEW	ppKKTGaG-lNGsAs-tts.oPKsLsos-sssPs.ShVhNGsQphsDoNlp.KsotKuhThuKsGl+sKshhpKssMDKKN..-KoaESKs+Es.plDKpEslsl.NGVloNNSGYITNGYsGK.GADNDGSGSESGYTTPKKRKAR+NusKGsEsLshhp-KhhQQc.ss..slt.pL-s.Ks..shscttGsRlEGhKPsaKh-sssuG..hupuc.sss-lQRKNSDsKs.GssuKKFEDRsKGKhuossuSKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKsAQss....u...........GEs.s.s.ts.......sRLSQVPMSAhKSVTSAoFSNGPVluGsDGsshss...ustslhss.AAuolss..ssuutssshs.-tussou.......AsEp+KsSLFIY...PSNMQslLPussQ....lshsup.TNQQsLGDIFQNQWGLSFINEPSAGPEsusscssccch.sEVoFQGE.pssshsopusphhPoGsp.hPsFPKAYELDKRTsPQ...uuhlKsu..ossE...uuuhspchph.h-.pKsDsuupGu.hVF.S+sp-l-..ss.AsPossLhuSAK-Q+Yp+GLER+-SWGSFDLRAAVlYHTKEME.IaNLQKQDPKRllTYcE	....................................................................................p+sG.htclNssss-tth.s.+s.sus-hspP..S...NG.spph.cssl....K.o.Ks.o.ststlps+sh.pKpsMDhKN..tKohE.pstEspshDKp-shsl.NGVls.NuGhITNGYhuK.uADND...GSGSESGYT.TPKKRKARpNusKusEslshhp-KhhQpcssss..lt.tL-t.+s..shscptGsRl-usKshaKhEstsuG..sspG+shhu-h.RKsSD.Ks.....GhsuKKhD-Rs.KuKtuosssSKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKssQssos.uss...........GEo..ts.ss...........sRLSQVPMSAhKolTSAsFSNGPVluss-ssh.ss......shhss.AAsolss...hssu.sss...-hshsos..............AhE.hKsoLhlY...P.NMQshL.ustp.....lshPup.TsQpsLGDIFQNQWGLSFINEPSAGPEsshupsscpph.hploh.tc.hst..shsopusphhsoGsp.hssFscAh-L-KRTsPp...hushhpsu...spE...utsh..c.p.h.s-.pKs-spopGu.hsh.Spsh-lc..ss.usPossLhuSsK-ptap+shERp-SWGSFDl+AAlhYHTKEME.lhpLQKQDPp+llhYpE..............................	0	1	6	20
+15147	PF15294	Leu_zip		Leucine zipper	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86TE4	Family	This family includes Leucine zipper transcription factor-like protein 1 (LZTFL1) [1] and Leucine zipper protein 2 (LUZP2) [2].	27.00	27.00	27.10	27.10	26.80	26.20	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.87	0.70	-5.29	18	148	2012-09-03 08:54:27	2012-09-03 09:54:27	1	4	59	0	78	120	0	222.00	42	84.38	NEW	FA+pKRshpLKoVDsCFpDLK-SRLs--TaTsDEVs-hLDGLpsVV+uEVEsELINou+TNVLLLRQLFpQAEKWaLKLQ.sDISELENRELLEplAcFEKp-houus.....p.s.-..ps.K....LpPLsEu.GsutLLs+EIpRLQEEN-KLKsRLKolEppATssL-EKsKLcpsL+-LQh...sp.cs....hhcuQ-ls-LEsplAslKsEhEKshpcposppKsLc-sLhssKHcLL+VQ-Q..LphAEKELEKKFppTuAY+NhKchLopKN-QIK-LR++Lp+	........shpchthpLKpV...Fp-.+pohLh.p.p.TaT.cEl.phLsGLpsslpo.hc.ELhNssaoshLLl+pLhppAcK.h.h+Lp.p-luElEs+pLlEplt..chEKtpho.s.......................Lts.s..Et.......hsK.ItcLQpENcpLKs+Lhohph.ss.th-EppKlpttLp-Lph............s.....hh...+uQplssLEpplAsh......K............s-hpKs.h.Dppp....p.KuLcEslths...hps....lh+sQ.....Lp.hhppp.pp.......hh..p...pshhpph.phhsppp.Q.pt....................................................	0	18	24	40
+15148	PF15295	CCDC50_N		Coiled-coil domain-containing protein 50  N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IVM0	Family	\N	27.00	27.00	27.00	29.30	22.00	24.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.92	0.71	-4.23	11	129	2012-09-03 09:22:21	2012-09-03 10:22:21	1	1	71	0	74	106	0	127.30	47	30.86	NEW	MuElpIDQSNLP.tVpEVCpsFAVLEDtuLAHNLQEQE..IEpahuoNlp+N+LVQ+DlpVAKpLQ-EE-....psps.hpppp+-LEcpDsEhAp.IQEcLhppAEctRppEpcDE-IA+pLQEcEhpEp+...R+p+ph	........................LP...tV.pEVC+-FAVLEDtsLAHsLQEQE..............IE.cHhuoNlpRNpLVQcDlpVA..KpLQ.EEDh...+Aps.p...h...p+ch+.....-l..Ep.........pDsElApEIQ..EcL.th..-....AE.c.pR....p..pE.c..cD.EcIA+hLQEcEhppc.++pp...h.....................	0	13	22	50
+15149	PF15296	Codanin-1_C		Codanin-1 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IWY9	Family	This domain is found near to the C-terminus of codanin-1 [1]. 	27.00	27.00	31.90	29.20	21.60	20.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.59	0.71	-4.25	23	96	2012-09-03 09:23:55	2012-09-03 10:23:55	1	1	75	0	64	95	0	117.00	46	10.95	NEW	ppslDshss..lspplLhssCPaLsEh+slltsshsstsps+....ushh+.pIT.......................Psusp.........t.sppplQt.pLE-AFF+sQPsSlRRoVEFVsERlsSNsVKchpssllhshhppupshlpphh	........p.puLDshsl..VDppLLYsCCPaluEhRpLL.uuhlusosu+...........suGhhR.KIT.............................................Psosp..t.hssps.spspptLQt.pLtpAFFHsQPsSLRRTVEFVAERluSNCVKHIKATLVs-llcpA-shLp-.h...........	0	19	24	43
+15150	PF15297	CKAP2_C		Cytoskeleton-associated protein 2 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IYA6	Family	This family includes the C-terminus of CKAP2 and CKAP2L. CKAP2 is a microtubule associated protein which stabilises microtubules [1].	27.00	27.00	47.50	30.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.45	0.70	-5.63	19	145	2012-09-03 09:24:35	2012-09-03 10:24:35	1	2	41	0	87	116	0	252.30	36	51.18	NEW	Apsssppsp+hhtps+shsppphpsspusss...........pRsstsKEoscE...R.+A+LsEW+suK.G+slKRPPhshh.......t..p.ptpp..EcsstSFWTThsEEDEQ+L....FT-KlNpThuECLpLIs.-GCP+EElLshLsclIpsIP-A+KLsKYWlCLARLEshpuslpclIuIYEcAILuGAp...PIEEhRcsls-ILp.hKsptp.sphupNhpptsssppplp-lp.........pt.shs..cstc.tp-ppcc+ssh.ppspppp-cppc.ssssslp.Tssp-sptuslIKYNVSoTPhLQShKKKhQh-pssu..sh+-LKFLTPVRRSpRlpcKss+LPDMLKDH.PCVSSL-QL.........sElssp.TssFlhR.NsAL	..............................................t.p..t...t.p..ts.h..................pst...Kpsst-....c.+tpLpEWptuK.G+shK.....RPP.phh............tttp..cp.shSFWpoh.....tcE-Ep+h....hopKlNpohoECLpLIp.pGs.tp-lhshLp....pIP.pA.cKhsKaWlChstl...push..pll.slYEcAlhsGAp....PlpEhRcslhsI.Lp...............stphp.pt..t........................................................ts.p...c.tpppp.....p.....p.pppp.th.sss.pht.psppcst..shIKhpls.shPhlpuh..................thp-hKhlTPVRRStRlpct...ss+hP-MLp-H.......sVuSLppL..........-ltt....spsalhR.NtAL...............................	0	10	16	33
+15151	PF15298	AJAP1_PANP_C		AJAP1/PANP C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IYJ0	Family	This family includes the C-terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration [1]. PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha [2].	27.00	27.00	29.70	33.30	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.60	0.71	-4.44	9	85	2012-09-03 09:25:14	2012-09-03 10:25:14	1	2	35	0	49	74	0	163.40	48	56.79	NEW	IsWGPTusD..lE-ss.suhhsssssssst..shTssossuToTstssps.sh.hThp..G...........P.thSThtss.s.sts.....sh.Pphhscsu.GLAVHQIITITVSLIMVlAALITTLVLKNCCuQSupsR+sSHQRKIpQQEESCQNLTDhoPupVsSslDIFTAYN-SLpCSHEClRsslPlYT-Etlp..ossaKouFNGNR	........................IsWGPTssc...Esss.Ps.hsPsh.sl......sh.suspshsTstss.ssth...phpspGlh.s.sP.........................ss.h.PhlhGspu.Glssp.hlTITlSlIhVlsA..TsllhK..C..hspStppRRsStQpth.p...QEESpQsLTDhoP....uulslhsAas-o.pso.-p.cspsssh...sh...pschtssFphNR....................................	0	2	6	17
+15152	PF15299	ALS2CR8		Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N187	Family	This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein [1].	27.00	27.00	27.30	28.50	26.90	25.80	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.60	0.70	-4.76	33	110	2012-09-03 09:26:01	2012-09-03 10:26:01	1	15	36	0	86	153	0	199.60	31	36.09	NEW	psshspsssclpWctt...........s.hlshsuhP............Fh........lhspthht.Cpa...Gpc+ctttpc+pppp.........................ptphphptocKhsCPA..plhl+...................clhpFP.................ca+lp...................................................................cspptp+cpshppL+pslhpt............hpsph.caalphPs.ppH.psHshtp.s...............................................shpptlc..............splhpKIccLVppG..lssl.plcc.pL.....ctalpcpha.pspphP.hpsp............pahPohpDl.....cschtpsppphc	..............................................s....ttstp+lhWcsp.............hlPa-GlP...............Fl...........htup..tsh...CQa...G.cRcthphc+hppp...........................pppspp.hKtsCPA..pIhl+...................cV.+FP.................-Y+lsst.................................................................c.h+hppccshphL+pslhs.............hsshh.RaYlpLP..sppsH.phH.htp.sh..............................................sh.pplc..............spltcKIp-LVupG..lpplhtl++.pL.....+pFVcc-LF.cscphPpppNh............paaPTspDI.....pN+htpsphph.p...........................	0	53	55	69
+15153	PF15300	INT_SG_DDX_CT_C		INTS6/SAGE1/DDX26B/CT45 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N7B7	Family	This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.	27.00	27.00	33.30	32.50	26.50	24.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.90	0.72	-4.52	36	206	2012-09-03 09:26:55	2012-09-03 10:26:55	1	3	71	0	105	190	0	64.00	48	9.46	NEW	cchNs-l+pplhKElR+sGRsYcpIFplL.cpVpGsl-l+ppFlchsIKEAsRFKR+sLlpp.LEch	.....pclNs-lKtQlhKElR+.GRcYE.+IFpLL.cpVQGslcs+ptFlc.sIKEAuRFK+RhLIpp.LEc......	0	23	29	55
+15154	PF15301	SLAIN		SLAIN motif-containing family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8ND83	Family	The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1 [1]. They are a family of microtubule plus-end tracking proteins [2].	27.00	27.00	33.20	30.90	26.80	25.20	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.75	0.70	-5.29	13	195	2012-09-03 09:27:58	2012-09-03 10:27:58	1	3	43	4	93	159	0	316.00	44	81.31	NEW	hLY......ss.pp.hssspKshSPlpWC.RplL-pPoP-hEsA+.psLph+L-Qh............................................................................h.s...ppsslSPQSSlD.....SELSTSEh--..su.uhsY............KLpDlTDVQIhARhQEES....LRQ-YAoTo..ussSRRSSShShpSh+...............R.ushSDQEhDt.ShE.-c-EphcpLshPpsphhssSP.........hp..s.P+Spo.Soh.................cpsR+Sspu..hs.tt.s.hpp.........................DKLRRShPNLs.Rssuhss.......................spsV+NSpShDSsLpsssuGluRhQSp.s.....l.pps+...usup.PlulRQPhKAsu.husslp..................us...t.hsssu.....shsspss.......s.s.....ossRSuLPRPusssssu.ssPRSKluQPsR..........................phLssPKo...h......usl+DsuW+DGCY	...........................................................................................p.up.psLh.+L-.h..................................................................................................................................................................................p...htssLSsQSSlD.....SELSsS-.....DSIu.sY.........................KLpDl.TDVQIhARhQEES....LRQ-YAuTo...........SR+SSusShpSh+...............+..GThSDQEhDt.SL-.D.--phcphs.Ptsph.psSP..........p..s.P+Spo.uph.................ppsRhS.pup.hs..ppp..ppp.........................-KLRRShPNLu.Rhssh................................oV+sSpS.DSshpssssGls.RhQsp.s...................l..p.h+...............ssu..PlslR.QPl...K...Ahu.husss..s....................st......sssu............tsstss..............h.......hhhR..SuLPRPuhs..h..s...G.sl..PRSKluQPsR..........................p..L.sPKs...h......ushpDtsW+DGCY...........................................	0	17	24	54
+15155	PF15302	P33MONOX		P33 mono-oxygenase	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96A73	Family	This family of proteins contains a flavine-containing mono-oxygenase motif. It may have a role in the regulation of neuronal survival, differentiation and axonal outgrowth [1].	27.00	27.00	77.10	32.50	19.00	18.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.82	0.70	-4.80	13	91	2012-09-03 09:29:03	2012-09-03 10:29:03	1	3	39	0	48	87	0	232.10	60	95.71	NEW	uGhLG+MSLPlGhpRRAhSYDDsLEDsAPMTPPPSDhuSplhWKpPVIP-+KYQcLucs..E-scssh......ssls.Suus-shsKlPVVKAKATplIMNSLITKQTQESIQ+FEpQAGL+DAGYTPHKGLosEETKYHRlAEAlH...KL+hQSG-.sKE-+QsoSAQS....TPSoTPpSSPKp............+.RGWFsp.......GSSsuLsGP-hS....ohDuGus-ts+ssu-KWSlFGPRo.lQKSso..G.......GFolQuY+GAQKPSPMELh+AQATphuEDPAsF.KPPKM-IPs.hEuK+..sPRsHNLKPRDMNVLTPTGF	..........hGtMSLPIGhhRRAhSYDDsLEDsAPMTPPPSDMuS.l.WK.PVIPERKYp.cLuc..hE-Gpsshs.....suhs.usuh-s..hppsPVVKAKATplIMsSLIT..KQTQE.SIQ+FEpQAGLpDuGYTPHKGLTsEET+a.hRluEulp...KLphQSGE.s+E-+.suSuQS....TPSoTPpSSP+p............p.R.GWFsp.uuosslsuss.s.....ohD.G....ssp......sts.s-+WShFGPRs.lQKsso..t.......uFuhQuY+GAQKPSPMElh+sQAsRhs-DPAs.h...pPPKM-lPs.hEu++...ss+sHpLKPRDhNVLTPoGF........	0	1	4	14
+15156	PF15303	RNF111_N		E3 ubiquitin-protein ligase Arkadia N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96B23	Family	This domain is found at the N-terminus of E3 ubiquitin-protein ligase Arkadia [1].	27.00	27.00	30.50	30.40	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.03	0.70	-4.87	13	116	2012-09-03 09:29:48	2012-09-03 10:29:48	1	3	41	0	57	120	0	236.70	51	37.61	NEW	hKuE.ssDAspptpsLct..ssPcshtsucshsschEshsuKsGs-h.p....-ot....t.susphpo..sLlhch+RcSpputsussp.....................-psSssctpc-SS.ScChpSPSSShHhGDSDTLSSs-Eptsstttuttt.ssts.............upopuuRpp+hsRSEoEoss..hMtt.p.+.........tpp++sssRhphVK......upRoQKQKERIhL.RpKREshAR+KYsLLpsSSoSsp.DLosDSSoSSSpEuE--l.....SGsS+s.ouslP	..............................................................tucshPttsEh.suKsust.sc.Lp.sp.ppptshsus..pp..sLlhch+RcSpput.u.sp.....................ppPos....pssS.scCh.SPSSShHhuDSDTloSsE-pEss.tcots...sut.............utoh.uRpp+hsRoEoEos...hMtt.p.+.........pS.c+.ssRhphVK......upRoQKpKERIhl.RpKREshAR+KYsLL.sSSoSsp.DLos-SSoSSS.-s-E-l.....oups+p.suplP.....	0	2	6	23
+15157	PF15304	AKAP2_C		A-kinase anchor protein 2 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96FF7	Family	This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds [1].	27.00	27.00	28.00	29.40	26.90	26.10	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.28	0.70	-4.83	18	145	2012-09-03 09:30:27	2012-09-03 10:30:27	1	7	47	0	79	126	0	242.10	23	39.72	NEW	I.sRPLLopsuhs...ssP.c...+-RuRs.SlalQRDltpETpREcDhRRp.Gh.......ttsusPshhspssp.stLpRthSS......cslLu.ssDupstsPsPEs...++Vs+hsscuYQshLssGss..chss....uhstPst..stttsps.t.spuths.t..hs.sssps.spp.t.....p..t...pst.shl..-..hlp...ht.ph.s....sph....p.hs.chs....ussslRht+sQuSsLLEcElcsVLcRERElpEpRRsshh.sE.......shsPss..s..hc.psup..uSopuuG..hsGohSVSES.hasslphaStLsasspsPs.ts...tpppctthYAGIps.Dtls.EllpuoRVoRHKNuhApRWEuGlas	..........................................................................................................................................................................................................................................................................................................................................................................................................h...h.s.t......tph..........t..t.........ushhlRtp+ppo.shlEcEl+uspEREcELpcQR.phh..sp..........................hhtPs..............c.................Ssotpss..........psshuspps...shtp.....p..ps.h.hh.h.......pt...tt......tpphp.................s.spllcuhRVsR+KsshA.RWEutIhs.....................................................	0	8	11	34
+15158	PF15305	IFT43		Intraflagellar transport protein 43	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96FT9	Family	Intraflagellar transport protein 43 (IFT43) is a subunit of the IFT complex A (IFT-A) machinery of primary cilia [1].	27.00	27.00	27.90	27.70	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.95	0.71	-4.17	34	125	2012-09-03 09:31:47	2012-09-03 10:31:47	1	2	100	0	81	136	0	137.10	37	64.49	NEW	Wu-c.......................u......pcpsppsscphp.tppphpstshp........t..............DIPl..IPDL.--lp.....-EDhhsplAsPPolpss.+VhTh+-LD.sDLhptsuhpsl.........DstlD............LpLLT+.sLsscpplc.EcDpsW-WDpLFTEVouElps-h.stpt	.......................................................................................t.tp..t.......tpthpt...p..........t.t.....................DIPl....IPDL--.lp..........-EchshpVAsPPolpss.RVhoa+-LD..sDLhc.hsAapsl........................DG-lD............LpLLT+.sLsPEcp.lc.EcDssW-WDpLaTEVoSElhs-hp...h........	0	33	39	60
+15159	PF15306	LIN37		LIN37	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96GY3	Family	LIN37 is a component of the DREAM (or LINC) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [1-2].	27.00	27.00	38.90	28.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.32	0.71	-4.22	48	143	2012-09-03 09:33:57	2012-09-03 10:33:57	1	3	106	0	95	141	1	153.20	28	60.56	NEW	hpps.sps.tt.ppo.............hlhcLa-RuV-Luphppp..ss..........LYs.lCRuW..hcNpsp...hstt.t..............................tsttspplhpLPpP..........tss.h.phPs.hp.ppppttppt..............................hotpsLlppHhpRWKclRp+....Wppp.pppphpR....YppohplLpt	......................................t.pp.....ttt.p.pps..............alh+LFDRSVDLupasps..oP............LYs.lCRAW..h+Ns..Pps.tht.tpst.s.............tp.............psscspslhpL..P.P.........ssssshs.plPsshp.ppptptspt.....p..........................o.ssLltpphpRWK+lRp+Wpct.pppp..RYppshplLp...................	0	31	41	71
+15160	PF15307	SPACA7		Sperm acrosome-associated protein 7	Coggill P	pcc	Jackhmmer:Q96KW9	Family	SPACA7 is a family of eukaryotic proteins expressed in the testes. Proteins in this family are typically between 104 and 195 amino acids in length. There is a conserved DEIL sequence motif. The function is not known.	27.00	27.00	81.90	81.70	19.40	18.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.50	0.72	-3.92	8	19	2012-09-03 09:34:46	2012-09-03 10:34:46	1	1	11	0	5	25	0	104.90	59	62.33	NEW	WQt.sphpPpp....pssGSsTEts..FsSppEDluElLDEILVQEIL-......uKTTspEhsSTuTTLpTth....AGh-ENYQtsu..oENYHEhLENlpaSSGTccclSsD-tsAsANLHu	........WQ..sp.cPpp....tssGSsTEIP..FSSKpEDhuELLDEILVQEILDh.....NKTTPoEMPSTASTLST.lH...AGIDENYQAGG..SENYHELLENLQFSsGhEsKlSNDEAsANANLHu.	0	2	2	2
+15161	PF15308	CEP170_C		CEP170 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96L14	Family	This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170) [1].	27.00	27.00	61.90	48.60	20.60	22.80	hmmbuild  -o /dev/null HMM SEED	691	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.26	0.70	-6.27	14	215	2012-09-03 09:35:26	2012-09-03 10:35:26	1	6	39	0	63	196	0	476.50	42	45.21	NEW	suchshphp.ss.s.p.sshusts.p...u.FVRQESFTKEpuSusls.sKLPHISSHPh..........LpDLpss+usph-h.opDT+LlLKETEosLAALEAKLhsppspt-st..........sssst..-DSLSG-SDVDTASTlSLlSGKstsssos...pt..shuuhQKEKSSossusQD....ss.sSARERLoEKp+p..ssts.tpsEss+R.hph+RupGspGSLDhTDD-+uSuhsa.PsoDhsoSDpEp.....uuRstsR+KP.st.....ssK-Epu+sotssp+s..........QQsLTRSNSLSTPRPTRAS+LRRARLG-ASDsEsADs-+us.u...ss.sussuKssspsKKLSRLDILAMPRK.RAGSFTsPSDoEus.s.RouFSGR..SlEthhsuRKs.osu-u...+suu++sAsus......s+QPh..oRsRouSs+YoSsosp....RRQpGSDYoSTSE-EaGSs+sSPK.H.....pRSHsSTAhQTsRspss.utsp.h...ss.u.....sppp---.pcEs-sY..hhs.TuchA.EI.ARL.SQsLsKDlAILAREIHDVAGDGDShoSuGsu.Sool..SolP..sTPASTISsREE..............LVQ+IPEASLNaQKVPPGuhu........sc.shDQs..hsDsp-cshup+pRshsR-E...............VlhDNLMLNPVSQLSpsIRENTEpLApKMKILFQNptRsWEElEAKIsoENEVPILKTSNKEISSILKELRRVQKQLEVINAIlDPsGsLDlhsuN+usu	..........................................................tp.................t..s........t.hlRQtSFTh-.soss...s.thlP+Isp...............tphtttptth....s.DTthlLK-oEsshAhLEA+l.pp..................tss....psSlSs-SDVDTuSTlS.hsucst.ps............s..+-pss.sss.ps.......sss+-p.pc+t+.....................puth..sShDhss-ppsss......s-.hsss.p.......s...spp....................p.pts+..s..................ts.s+psoLstPRPTRsShLRRARLG-sSDs-.s-s-+hs.t....t.....sst..s.tt+tlSRlDhLA.PR+.RhGShss.SDsEss.s......pss.SsR..ss..E.h.t.th.....sts....+.ss+httssh........s+.s...s+s+s.ssthssss...............................................sshp..p.t..s................t.pcc...cE.-.Y..hhs.Tsc.t.EI...A............Rl.......SQ....DlAllAREIpDVAG-hDS.sS..su.su..uso....tshs.ssPu..osl..ss+-E........................LVp+l.-tS.......LNapKlPPhshs...........st.s.c.p.....s-..c.....+pRsh..sR-E...............shhDsLhLssV.QhSptIRpsh-phAtKh+ILFpsptRsW--lEuKlpuEsElPllKTSshEISSILpEL+RVpKQLpsINshlDPsGsL-h.h.s...h.....................	0	4	11	30
+15162	PF15309	ALMS_motif		ALMS motif	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96L16	Family	This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), KIAA1731 and C10orf90 [1-2].	27.00	27.00	27.00	27.00	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.76	0.71	-4.33	17	152	2012-09-03 09:36:21	2012-09-03 10:36:21	1	5	71	0	88	160	0	123.80	34	9.40	NEW	shl+hoLQEALph+RPDFIS+StcRlKRL..cLlscER+hQphhppERctLFs.s....cp.tt....s..hshp...hth.+..pRslsKKEMlpRS+RhY......cpLPEVp+++EEE+RcscYpo.RL+AQLYKK....KlpN...plhG.++s.hp	...........................................phoLQEuLph++PpFluRSppR...hK+L...chhsp..p.R+hp.phhpt...cpp..thhs....................tt.......h.h.shp.s.hhhs+.....pRhloc+EMptRo+RlY......ppLPEVpp++.EEp+..+ctt.......hpoNRL+AplF+K....plhsplht+p....s.....................	0	24	31	49
+15163	PF15310	VAD1-2		Vitamin A-deficiency (VAD) rat model signalling	Coggill P	pcc	Jackhmmer:Q96LK8	Family	VAD1-2 is a family of proteins found in eukaryotes. The family is expressed in testes and is involved in signalling during spermatogenesis.	27.00	27.00	165.10	48.60	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.65	0.70	-4.71	8	28	2012-09-03 09:37:07	2012-09-03 10:37:07	1	3	21	0	13	30	0	218.50	53	65.13	NEW	EE-QV.sssHRSIRVQTSKHLFWADKLIQASEHSLQ+thshQ.t+posscTsup.spp.l.pcshsSc.cQLQsPSspPs.PuTsS.Q..P.oPp..SS..sLoPAIGLAELlNFASSLAlASSSKhDLPNLEHMIKuPPQ...KAppPST-Pss...p.As-pp-tcpp.....sch.sEKP.LEss..EspKuaKQEDKNls+PYLDFSKPGhKRATIEGEVKLLQsPAhSPp.QGApKDSVPGTKKGoPLLLKIHFKLSSPoSPE	..........EEpps..Sus++SIpsQTSKHLFWAsKLIQASEHSLQ+slshQ.pptSsspshpp.hppslspsshsSc.cQlQ.PsupsuPPsTuSQt..PSPh..SS..sLsPsIGLsELIsFASSLAhASSS+hDLPsLEHMhKAPPQ...cAhEPSTEPhh....p.ss-cp-scpp.........sEt.sEKP.tEAt...ts.KuWsQEDKNhspsYhDFSKPGlKRATIcGplpLLQsPApSP.LQGuccDSVP.GpcKtsPLLlKIHFKLSuPo.PE............	0	1	1	1
+15164	PF15311	HYLS1_C		Hydrolethalus syndrome protein 1 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96M11	Family	\N	27.00	27.00	27.10	27.10	26.60	25.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.22	0.72	-3.75	20	80	2012-09-03 09:37:52	2012-09-03 10:37:52	1	2	70	0	59	82	0	79.30	40	26.71	NEW	IRPthpt.pppt....tKsDPVs+YapY+cpWcph+sP.GEcpRpsLRWplREpMhpps....s..+s.+hhl.PNsYlVPTpKKRpALRWplRspLA	.............IhPhhsp.pppp.....tKsD.Vu+YapY+c-Wcph..+..hP.GEccRppLRWsVREpMLp+s....s..hs.+hhl.PssYlVPotKKRpslcWtlR..hs...................	0	20	22	41
+15165	PF15312	JSRP		Junctional sarcoplasmic reticulum protein	Coggill P	pcc	Jackhmmer:Q96MG2	Family	JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalises with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.	25.00	25.00	30.60	29.70	23.40	18.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.11	0.72	-4.01	17	32	2012-09-03 09:38:57	2012-09-03 10:38:57	1	1	26	0	19	27	0	67.50	50	25.24	NEW	s-ELPWG-lTLNKCLlLASlVALLuSuFQlh+......DslsGptssst..sPt.Wl..Pou.ss+c..st.sPtP......c	..p-ELPWGDloLNKCLVLASLVALLGSAFQLC+......DAVsG-ssh.t..sPtsWV.PPSS.sP+c.ss.uPhPc.........................................................	0	1	2	7
+15166	PF15313	HEXIM		Hexamethylene bis-acetamide-inducible protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96MH2	Family	HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.	29.00	29.00	29.70	41.00	28.90	28.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.59	0.71	-3.95	25	120	2012-09-03 09:39:46	2012-09-03 10:39:46	1	2	80	4	79	116	0	132.50	41	43.16	NEW	WK.PY.K.LoWc.............E+pph-Epps..pRAsRl............hu+GpPlAPYNTTQFLM-DH-tpE................................scLssssthpcttss.........................sspst.hsup-Dp....................................................FLp+-FS-sYEph+.sEpLpsMSKpELlpEYLcLE+chuclc	.............................................W+PYhc.LoWp...........................E+pph-E+po.....pRAoRlRt.....pMFA+GpPVAPYNTTQFLM-DH-.cE........................Pc...Lcssph.p+ss..sps.................................................ssssp.tspscsct-.........................FLp+DFSEsYE+hH.sEpLQsMSKQELlpEYL-LE+phSph......................	0	23	29	50
+15167	PF15314	PRAP		Proline-rich acidic protein 1, pregnancy-specific uterine	Coggill P	pcc	Jackhmmer:Q96NZ9	Family	PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homologue. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression [1].	27.00	27.00	54.30	30.00	24.00	21.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.76	0.72	-3.67	15	33	2012-09-03 09:44:09	2012-09-03 10:44:09	1	2	22	0	16	31	0	44.80	55	28.18	NEW	PE.D+DsLYH..PtspE...sQtEscPhsp...sl.s+pVLp..GPEED+DHIYH	..PEPD+DuLYH..P.s-E...sQsE-pPhhh...shss+QVLp..GPEEDpDHIYH	0	1	3	5
+15168	PF15315	FRG2		Facioscapulohumeral muscular dystrophy candidate 2	Coggill P	pcc	Jackhmmer:Q96QU4	Family	This family of proteins is found in eukaryotes. The family is localised close to the D4Z4 repeats on chromosome 4 and 10 that are associated with the autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). FRG2 are transcriptionally upregulated in FSHD myoblast cultures suggesting involvement in the pathogenesis of FSHD [1].	27.00	27.00	29.00	28.50	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.39	0.71	-4.31	8	40	2012-09-03 09:44:56	2012-09-03 10:44:56	1	1	15	0	18	49	0	172.50	58	68.15	NEW	GSEPppcE.-sSpEo-hptps.SsusoEsESuophEusRKRKhSS+DSopsssGus...st..EsSsohcpK+.Rsss.us+ssEspcsusu+pcspu..tsG+pcRpRsRs.sscPPPlRKSLVToLRuhSEAIYpDlsQhpAQQttSPLT.EQLstLuQLpGPLsAslQTlYoMAsQAAaAFPAEGWL	..............................GSEPsPNc.ENScEoKL+usN.SoAsSEsESSShpENsRKRKISS.+DSspDpAGNC......Pc.cEsSloLpKKu.RuST.uVHsSEIQETs-uH+RGpSRApoG+u+RHRSRuhuspsPsLRKSLVTSVRuhSEAlYQDLAQVhAQQh+SPLTpEQLohLoQLRGPLCAtVQThYoMAoQAAasFPAEuWL.....	0	3	3	3
+15169	PF15316	MDFI		MyoD family inhibitor	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q99750	Family	Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors [1]. They affect axin-mediated regulation of the Wnt and JNK signaling pathways [2], and regulate expression from viral promoters [3].	27.00	27.00	50.20	49.80	25.30	24.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.44	0.71	-12.10	0.71	-4.27	9	115	2012-09-03 09:45:47	2012-09-03 10:45:47	1	1	42	0	61	106	0	162.80	51	76.62	NEW	QPps..........lPh.ssustcs.ptEhGphps.......sGs.....Gsh....ss..............p+hp+KlposhSlsSsuu+KSKsuo.....sppsuphP..tp...DCCVHCILACLFCEFLTLCNlVLspAoCGh.CoSEs....CCCCC.GsshGsDC....sCPCDMDCGIhDACCESSDCLEICMECCGICFPS	......................................................................................p..thps.....lsNGs..Gh.p..Gstphuus........h.u..Assu..pKhH.RKlQ.op.SlsSpsSKKSKssu.....pppsup.P...tE..DCCVHCILuCLFCE...FLTLCNIV...LspAoCG.......CoSEs.....CC......CCC.......Gst......s...sDC....shPCDhDCGIhDACCESuDCLEICMECCGlCFsS.....	0	2	9	21
+15170	PF15317	Lbh		Cardiac transcription factor regulator, Developmental protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BQE6	Family	The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart [1].  More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions [2]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.	27.00	27.00	28.10	33.50	26.60	17.70	hmmbuild -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.47	0.72	-3.73	18	80	2012-09-03 09:46:51	2012-09-03 10:46:51	1	2	40	0	42	78	0	86.90	56	67.14	NEW	MTEV.hso..ssh--hsls.......PccspLohQIFPDsu-h....-cssK......LKcRLPSIVVEPTE.uEVESGELRWPPE-hLlp.p-pc-ptt-pthpsppp	........................MTEVhMso..ssM--huLs.......PcKDtLSaQIFPDPSDF....-RsCK................................LKDRLPSIVVEPTE.GEVESGELRWPPEEFLlpED-p-pspEsttpsp..................	0	2	8	19
+15171	PF15318	Bclt		Putative Bcl-2 like protein of testis	Coggill P	pcc	Jackhmmer:Q9BQM9	Family	This family of proteins is found in eukaryotes. The family may represent a set of Bcl-2-like proteins involved in apoptosis, see UniProt:Q9BQM9.	25.00	25.00	69.60	40.30	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.37	0.71	-4.28	6	22	2012-09-03 09:50:31	2012-09-03 10:50:31	1	3	17	0	10	20	0	140.00	60	88.05	NEW	MGNsSSHKRTKAPKQA+KE+PPDMDKA+t.+QFFSHLKpK........KPus..................uhhsKIVLLFPLDKRQQLAEA.......ut.s......-cssG.....As.s....uhPA.APMLRGAGDus-RR........c.......ch.plhlLL...hlt.-uhhttc.........G.......GuKuAQsWQcLas+LLocuEA-sEuss.AEEQPRKRR+CPR	.....MGN.SSHKRTKAPKQA+KERPsDMDKAha.KpFhsHLpRK.............KPus..........................+IVLlhPLDKRQ.LApA........sp..-.ssG.....As.h....u.PA..APhLRGAG-Gs-Rc..........ch..lhlLl...h...-sh..t-..........G.......GA+us.sW..Lhs+hho.tcsstEuts.tcpQPRKpp+s.R...........	0	1	1	2
+15172	PF15319	RHINO		RAD9, RAD1, HUS1-interacting nuclear orphan protein	Coggill P	pcc	Jackhmmer:Q9BSD3	Family	RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins [1]. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N [2].	25.00	25.00	37.30	32.90	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.76	0.70	-4.55	18	48	2012-09-03 09:51:53	2012-09-03 10:51:53	1	2	35	0	26	42	0	219.60	49	98.14	NEW	MPP+KKRpppspKAQLLF+ppPLEGPKHchuSPQhsh.THT..RQVPoKPID+sTlTSWVSPQFDsTsEoaFPuppK....H.R.......c........pA+pSSRKSsos..KFPpLoFEospoS...S.S.-.sL..uls..hs+......-s.PsQscKDlopRPLVPhLSPQSCGElSs+.....sLpohPhVFlPPDIQTPEsS......sl+p....s......slPs-p+csuLsu.CshHssoPpSP-PGPVLVcDTPEEKYGlKVTWRRRcHLhsYLRERGKLS+SQFLV	.......................MPP..+..KKR...pp.opKApLLF+ppPLEGPKHphuSsQhsh..THT+QVPSKPIDps...TlTSWVSPQFDssupoh.FPstpK....Hp..............s...............pA++uSR+osos..KFPcLoFEospsS...S.S.-.sL..uhs....hh+...............cs.Psps...cKslsp..RPLlPhhSPQSs.uphSsp.....t.pshshVhhPPDlQTPE.S.......s+p............p..ls.spppsph.s.s..tssoPt.ss-PusVLVcDTPEccYGlKVTWRRRpHLhsYL+-RGKLspuQhLV........................................	0	4	5	10
+15173	PF15320	RAM		mRNA cap methylation, RNMT-activating mini protein	Coggill P	pcc	Jackhmmer:Q9BTL3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 154 amino acids in length. There is a single completely conserved residue D that may be functionally important.  RAM is a family of eukaryotic proteins that are an obligate component of the mammalian cap methyltransferase, RNMT (RNA guanine-7 methyltransferase). RAM consists of an N-terminal RNMT-activating domain and a C-terminal RNA-binding domain. Either RAM or RNMT independently have rather weak binding affinity for RNA, but together their RNA affinity is significantly increased. RAM is necessary for efficient cap methylation, maintaining mRNA expression levels, for mRNA translation and for cell viability.	25.00	25.00	25.90	28.30	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.06	0.72	-3.72	24	82	2012-09-03 09:53:27	2012-09-03 10:53:27	1	2	67	0	60	71	0	82.00	43	64.28	NEW	pchE-hFssRFT--DpEapcahp..+PscsPPlV-sW..p.....u...p....suGsp.........+sp.ssphp.s..pcph....pGpstpt...shpstsR..pp.pa.ps.R...saup	...saEEhFAsRFT--DcEYQEYlc..+Ps-sPPIVEpW...p.....u..R....uGGsp.........................Rsc.sNphp.s..sRpa....cGcss+t...GWsscs+..tp.pa.ps.R..sht....................................................	0	10	14	33
+15174	PF15321	ATAD4		ATPase family AAA domain containing 4	Coggill P	pcc	Jackhmmer:Q9BU68	Family	ATAD4 is a family of proteins is found in eukaryotes. The family is also known as PRR15L, or proline-rich 15-like. ATAD4 is expressed almost exclusively in post-mitotic cells both during foetal development and in adult tissues, such as the intestinal epithelium and the testis. Its expression in mouse and human gastrointestinal tumours is linked, directly or indirectly, to the disruption of the Wnt signaling pathway.	25.00	25.00	25.00	60.40	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.29	0.72	-2.98	28	78	2012-09-03 09:54:15	2012-09-03 10:54:15	1	2	41	0	44	68	0	89.60	47	75.69	NEW	WWK.LThhRKKps....ps.+VhhpsP.................................sp.....us.........ss..sspp.......s......s.....p....sst.stcs........phssRL....-Kls.ccp...sppRplKVS+SGRFKEK+KVRATLs..p	...................WWK.LTh.RKKcu....ps+Vhh-hP.................................sph....us............ss..uusc.......t......s...ps......sst.sssu.........shssRL....EKls-cp...optRplKVS+SGRFKEK+KVRATLs-p.	0	4	8	19
+15175	PF15322	PMSI1		Protein missing in infertile sperm 1, putative	Coggill P	pcc	Jackhmmer:Q9BUN1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 249 and 341 amino acids in length.	25.00	25.00	26.10	26.10	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.20	0.70	-5.34	11	35	2012-09-03 09:55:01	2012-09-03 10:55:01	1	2	23	0	14	27	0	272.00	60	89.90	NEW	AQG.Tpo.Tu....hQRVSFRFG.....GP.ho..RoY+oTu..RT...shPR+hR..VThEDEsDssAsADRLAGPAAAELLAoTVuTGhu+sp...ss.s....-EDGSLEEGVVIsARKsso....shct.sssspT.stusoo..RFhANoQEPEIRLTosl.suoh+sTt..-.lsS-sTLopWSTAGSTPsRWPsPSPTAMPP.PEDLRLVLMPWGPWHCHCKSGTMSRTRuGKLpGLSGRLRVGALSQLRTEHRPCTYpQCPCNRc+EECPLDouLCsDosCoopsosp...ohsshPslahRhpPs.h....s...SP..SPALAFWKRVRhGLEDIWNSLSSVFTEMQPl	..........AQG.TpTsTt....MQRVShRFG.....GP.hs..RSYRoTu..Ro...slPRKhR..lhLEDENDAhAsADRLAGPAAAELLAuTVuTGhSRSS...s..s....EEDGShEEGVVIsAtKsso.........stchsSssssT.sGuSST..RFhANoQEPEIRLTosLPposh+sTp..D..sS-sTLopWSTsGSTPsRWPsPSsTAMPs.PEDLRLVLMPWGPWHCHCKSGTMSRoRuGKLpGLSGRLRVGALSQLRTEH+PCTYppCPCNRh+EECPLDouLCsDosCuopsTTp...ossshsslHhRppP..h...Pss...SPsPALAFWKpVRIGLEDIWNSLSSVFTEMQPl...............	0	1	1	1
+15176	PF15323	Ashwin		Developmental protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BVC5	Family	This family of proteins are found in eukaryotes. These proteins have an important role to play in developmental biology, particularly embryogenesis. It plays an important role in cell survival and axial pattern [1]. It is also thought to be a crucial subunit in the tRNA splicing ligase complex[2]. Proteins in this family are typically between 141 and 232 amino acids in length. There are two conserved sequence motifs: HPE and PQR.	27.00	27.00	32.40	32.40	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.46	0.70	-4.34	17	75	2012-09-03 09:55:43	2012-09-03 10:55:43	1	3	67	0	50	70	0	183.50	38	84.61	NEW	ss.hLLHPEL..LSc-FLlLhLp.p+sIhscs....p.sKDpLT-LYlpHslPLPQRcLPcsRWGKhhEKpRt.p.th......tspp............ppssss-s.RKRPLI.........VFDGsSoso.slKl+Ks-su....ss.DRLKPPP.s..hossl+KLSssospsSsss..ss................p.s........spsshts.ps.P.o.........hstssssKL.....................KRsuspp.-sssss-hKssEsK+KIQHV..TWP	.........s.-hLLHPEL..LSpEFLLhhLc.p+....sIsVEs....+hsKDsLsDLYlQHAlPLPQR-LPcsR..WGKhhEKcRp.pp.ch......pspp..........................ppss..ss-s....RKRPhI............VFDG.sSooo...olKl++s-su......ss.DRLKPPP.t.......hossh++lptsss.psus.....s....................p..........tpt.....p....p......ht.sssspL.....................KRssspp.t.p..tphpsspsK+KIp+l..TWP..............................................................................................................................................................	0	12	15	32
+15177	PF15324	TALPID3		Hedgehog signalling target	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BVV6	Family	TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.	27.00	27.00	34.00	33.50	24.10	25.60	hmmbuild  -o /dev/null HMM SEED	1252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.39	0.70	-14.02	0.70	-7.21	10	106	2012-09-03 09:56:21	2012-09-03 10:56:21	1	3	35	0	35	97	0	709.20	48	82.78	NEW	sDIFISQYosGQKDALRAVLKQKAQShPVFKEVKVQLLEDAusEKcsl.uQEsRhSPuGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVoELLsKLQETDKQLQRVTEQQTsl.QsKpEKlHCHDH....EKQMNsFMEQHIRHLEKLQQQQIDIQTHFISAAL+ouS...aQPsslPsSRsVEKaslKs-psslGuushSS+ssFss+p..As...................h+psEDhuFDcQKSPLETPAPRRFAPVPVSRDscISKRENPhEEKENh-hssp+GssRLLEQILNspDo.oRKSESS-.tTSLopSKhGWNPE...+ps........pFPSsEELGTAcVTVQKu-DlLpDLGQK+KEoculLQ...KpS.shlcLuDhPQsss.+.............LQoTpsTRSlLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSFINALoTNREhoEKIRIRKTVDEWIKsISAEIQDELuRKDYEQKRFDQKspRsK+ApsM.......SK-IKsNTQ-Ks...lN+ssh.tK..pKQlE..-phcs..lpshs.Sshp.+cR+-GhLKussllQDEDYhhQlYGKPVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIEpVKGTKVKShRTQTDhaATKPlKhDSKhpHSlshLP+u-.QQYLFSPSREMPThSGTLEGHLIPMAILLGQTQSNSDShPPAGVlVsKPHPVTVTTSIPPSSpKscTGVKKPNIAVlEMKSEKKDPPQLTVQVLPNVDIDSISNGSu-sS.s.ssSPcEAS.sPlpsWIQsPEhhKsDEEElKFPGoNFDEVIDVIQ-EEKsDE.IPEaSEPlLEFNRSlKVVSTKYNGPPFPPVASssQPTsDILDKVIERKETLENSLIQWVEQEIMSRIISGhaPlQ.pQsssslSVSsSEsSEPlTSDIVEusuGGuLQLFVDAGVPVNSDMIsHFVNEALAETIAlMLGDREu++ssPsAssVPGsloosET.L.ARlsTPVATPQPTPPpS....PsSssKEhVLVKTP-SSPCsS-HDsshPlKElhAEcGsD.hPAlTLVsTPsVTPsoTPPPA.AuhTPThSEhSI-KLKhsSPELPKPWuDuDLPL-EENPNslpEEshaPRAlVMSVAKDEEPES.chPs.PusPc.PlPhpPhPsus+APSsspsPSS-SST.ESoLShT.sTETETLDRPISEGEILFSsGQ+LAs+.luDuG.LaLsNLNDSLSSTLpDAhEMEDDPPSEGQV.IR+PHKchHpDslLSLLAKQNQcslsSQQulYHSEDLENSVGELSEGQRPpLsAAAEsIhMGp	.................................................................................Psh+tV+Vplhtsst..+t...s.c.t.s.pthpsssolAAATAAAIAssAPLlKsQpphpAplspVsphLpKLppspt.l..h.t.t.t....p.p....tp................................sphIsuAhp.tt...h.......hssst...h...c.t......t.....p.h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	5	11
+15178	PF15325	MRI		Modulator of retrovirus infection	Coggill P	pcc	Jackhmmer:Q9BWK5	Family	MRI, or modulator of retrovirus infection, is a family of eukaryotic proteins that regulate the activity of the proteasome in the uncoating of retroviruses [1].	27.00	27.00	27.70	41.30	21.10	25.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.51	0.72	-3.07	14	32	2012-09-03 09:57:11	2012-09-03 10:57:11	1	1	25	0	17	32	0	99.20	66	70.21	NEW	TVYCMNEAEhVDVALGILIE.uRKQEKPhEpsslAGADKPEhSP....ssStSPtsSS.GusSE-EDsGpDu.sP..GLuPspsPuGScSACScSPEc...-EDsLKYVREIFFS	.TVYCMNEAElVDVALGILIE.uRKQEKshEQsuLsGADpPEhSP....ssSsSPaoSS.GSoSE-EDuGc-u.sP..GLSPSQtPuuSsSACSRSPE...E..E-EDsLKYVREIFFS...	0	2	2	2
+15179	PF15326	TEX15		Testis expressed sequence 15	Coggill P	pcc	Jackhmmer:Q9BXT5	Family	TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination [1]. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population [3].	27.00	27.00	307.70	44.90	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.58	0.70	-4.73	12	63	2012-09-03 09:57:43	2012-09-03 10:57:43	1	4	25	0	32	57	0	220.00	40	16.72	NEW	N..hsKR..c+pGchKs.SpcsQo.spth..phshh.SKPulh.tlsphPlhct..+Schscs.s....pss...s-LcEpHsosspsuhlscLSpILQRADEASSLphLQEEocsCQNlLPLFVEAFERKQcCShcQILISR-LLVEpNLWsN.CKa+LKPsAlDoLVELQMMMETIQFIENKKRLLtGEPTFRSLLWYD-oLYuELLttP+GaQQQSsFYPuFQsRLKYNAFsELQpYHsQLIELh	...........................................................................................p........p...hh.tcst.h..thsp.slh.tppcsspls........pcsss.hpphK.pps.h.s...Hss.IsslSpILcpA-.susLphLQE.ThhCpshL.lhhchFphhQEssl-pIhIocE...llD..sl.pN.sp.hhLKPpAl-ohlEl.Mh.ETIpFlcNpht+hhsc.pFRuhLWaD.SLhsELltp.c..............................................	0	2	3	5
+15180	PF15327	Tankyrase_bdg_C		Tankyrase binding protein C terminal domain	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BY89	Domain	This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyses poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase [1]. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.	27.00	27.00	28.00	28.00	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.49	0.71	-4.08	17	95	2012-09-03 09:58:28	2012-09-03 10:58:28	1	3	38	0	50	89	0	166.70	50	15.10	NEW	s.cFuF..tpTslLDS.SAL+oRsp....Lu++.pp..+RAPsStuhRt....sR..ts.sthshs--ss.sWhFpDS....sppp+ss.p--u-.t.E.t+s.+ocpssssps.+lslFPGhDPSALKAQLRKRs-u........-u.s-t...ussQhSKSPKsPh.h.G..usRVLPPus-K-suSE-.sSPpWL+-LKSKK	...............................t..DFSF.I-pTplLDS.osh+oRsp.Lu++.pt.+RAPs...........Rsuto..t.s.ts-sD.sWhFpDS....sptp+sP.pp-p-..EE.pspRochosso+s.+lslFPGhsPSALKApL+pRscu..................-S.upp...ShsQpuKSsKsPh.h.G..tshlLPspsEKspt.....SEt.sSPpWLptLK.KK......	0	2	5	16
+15181	PF15328	GCOM2		Putative GRINL1B complex locus protein 2	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BZD3	Family	This protein family is named Putative GRINL1B complex locus protein 2. GRINL1B is short for: glutamate receptor, ionotropic, N-methyl D-aspartate-like 1B. The name indicates what sort of receptor it is thought to be, a ligand gated ion channel specific to the neurotransmitter Glutamate. This family of proteins is found in eukaryotes. Proteins in this family are typically between 325 and 463 amino acids in length. The protein is thought to be the product of a pseudogene with a role in helping assemble a gene transcription unit [1].	27.00	27.00	27.00	27.00	26.40	26.70	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.46	0.70	-4.60	48	192	2012-09-03 09:59:30	2012-09-03 10:59:30	1	2	70	0	83	176	0	245.50	28	63.40	NEW	hLcRQp+lLpN.........++hlpcLPDKGcKIpchhp+lpstlsc+.c-l-pp............uphhpsLslssp....tth..sphphpttt.pcphhphsshh.tsp..sppcpstht.hsQ...........ss.ctpthhhhpsssshhst...........................ts.t-htphh......t......t..............................................p....................p..p+ht.hhpppp++..................................cshchcsKhpshpssp	..................................................................................................hpcp.phlpp.....................................cchhtphs-htp+l.p.htcl.ht.tpp.c.lcpp............sth.psls.s..sh....tth..sshphpttt.p-thhphpph..tss..p....p-ppp.hpssQ..s.hh+hp.tpopctsspVhhEhotplhsp...........................tshpEuspthpt...tEhshp.p+-pcluEl.......p+hltthppEpptL..ph...........................................h..t...s.u-ppc....pp.LEc.tsssL+E+I+HLcDMlcsQQ+KV+tMl.............................tEs.Ehps+hc...........................................................................................................	0	13	17	43
+15183	PF15330	SIT		SHP2-interacting transmembrane adaptor protein, SIT	Coggill P	pcc	Jackhmmer:Q9Y3P8	Family	SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.	27.00	27.00	27.40	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.69	0.72	-3.90	36	122	2012-09-03 10:10:56	2012-09-03 11:10:56	1	3	34	0	64	132	0	102.10	28	42.21	NEW	hhLhslhullL.Ll.Lshslhtahtt++pp+ssph...........................tslE-sPlYGNLshhps...sshspsshcphpspPppSspspp...Ehss.s..hscpphsYASLshss.sp.c	...hhLhsllulLL.Ll.lsssLhtWphh.p+ppKhsph............s......ppsttsh.E.ss.h.YuN..Lshh.s...tshsppshpphps..Pppusptt....Ehss.s..hsccphsYASLshss.tt.....................................	0	5	5	14
+15184	PF15331	TP53IP5		Cellular tumour antigen p53-inducible 5	Coggill P	pcc	Jackhmmer:Q9Y2B4	Family	TP53IP5 suppresses cell growth, and its intracellular location and expression change in a cell-cycle-dependent manner.	27.00	27.00	77.00	38.00	23.80	21.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.46	0.70	-4.43	14	41	2012-09-03 10:11:55	2012-09-03 11:11:55	1	3	28	0	22	33	0	185.80	51	80.98	NEW	pQPVSKlIERNRLKMVLKNLSLLKLLKSSNsRIQELHNLA+RCWNSLLRVPKILpISSGsssVssKscQNNcEhQE.AsssccpLESKKhE.SsuEPK.....t.csc.tst.pstsptSPuAVsp+EcQhEsElP+TS+ucGL..s..PGApu+QssTtsPpVlhLKTapp+TPhtDhKQL-.sADQasWFEGLPTRIHLPGPRVMCRuSoLRWVKRCCTRFCSASL	...........................QslsKhlERNRL+hVLKNLSLLKLLKSSN.RIQELHpLA+RCWpSLLp..VP+ILpISSupsssss+scQsscEhQE.hssspcpLcSK+l-.usu-PK.........c.ps..t.thpsttptS.uAhs.+-cphcs-lP+Ts+spuL..s..ssApu+Q..TcsPpllhlKsappRsPhtch+Qh-.hAcQahWFEGLPTRIHLPuPRVMCRuSsLRWVKRpCTRFCSASL........................................................	0	1	1	5
+15185	PF15332	LIME1		Lck-interacting transmembrane adapter 1	Coggill P	pcc	Jackhmmer:Q9H400	Family	LIME1 is a family of eukaryotic transmembrane adaptors. It plays an important role in linking BCR stimulation to B-cell activation and is expressed in primary B cells. LIME localises to lipid rafts in T cells in response to TCR stimulation [1], and is phosphorylated by Lck and recruits signalling molecules such as Lck, PI3K, Grb2, Gads, and SHP-2 [2]. LIME acts as the transmembrane adaptor linking BCR-induced membrane-proximal signalling to B-cell activation [3].	27.00	27.00	32.50	35.30	26.00	21.00	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.71	0.70	-5.12	8	37	2012-09-03 10:12:49	2012-09-03 11:12:49	1	2	22	0	14	35	0	187.90	51	73.69	NEW	LCTsC....HR.D-.L..RKpupRQpuRLQGohMPuEhSLLRQspLCSLSKSDTRLHELHRGPpsS+A...RPASMDLL+PpWLEsSRussRs...PsAFsHRELPQu.PuA....s.husEATYSNVGLAAIPRAu...........LAAsP.VV................AEYAClQK.hKGT-pGP.....Qs...LpQuKAclpPAsQVDILYSRVsKPKRRssuPs.....sDQ.DPKupusILsL........GSD.uYEsL.PLpGpuh-su.LENVYESIQE	.................................Ktspcppst.psshhss-hsLLRps+LCSLSKSDTRLHELHRGspsohA...RPASMDLL+P+WLEhSRusops.ssssAFs.ppLPpA.PAA..hssshusEATYSNVGLAAlPRuS...........LAASP.VV.....................AEYAslQK.hKGTcpGs.....Qp....tQ.KschhPAsQhDlLYS+lpK.t++s.tss.....ss..s.pstts...h........tss.tYpsh.s.hu.thppt.hENhYESlpE...........	0	1	2	2
+15186	PF15333	TAF1D		TATA box-binding protein-associated factor 1D	Coggill P	pcc	Jackhmmer:Q9H5J8	Family	TAF1D is a family of eukaryotic proteins that are members of the SL1 complex The SL1 complex includes TBP and TAF1A, TAF1B and TAF1C, and plays a role in RNA polymerase I transcription [1,2]. Alternatives names have included 'JOSD3, Josephin domain containing 3'.	27.00	27.00	153.10	70.30	23.90	23.00	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.71	0.70	-4.55	12	58	2012-09-03 10:13:26	2012-09-03 11:13:26	1	2	34	0	33	42	0	201.10	57	79.67	NEW	SuSSLF+TQClP.oPpp+pR.ss..Rp.slpustslp.pDSSSDSS.hE.P.pP..LsLKA.IFE+FKK+....KK++.K..RKYKP...Tt+.h.GRPcG++s..s+hSp..h-K.+plKDKG.pFPFlESE.s.+KsLPW+KILoaEQAVARGFFNYlEKLKYEpHLKESLpQMcsGEDLEcEDh-sR+YKYLDDDGuISPIEEsssED-.ssss..cp.s..-CDlKLV.E.sS.FIlSo-hP+K	...............SsSSLFKTQClP..hSPKpppR.Ns.hRK.hVcss.tsVpspDSSSDSS.hE.P.hP..LTLKA.IFER.FKp+.p...K.K+KK..RK...Y+P....oGRP+.GRP........cG++s.........sphS...l-K...KQh+-+GssFPFLESE.s.cKslPW+KILoaEQAVARGFFNYlEKLKYEaHLKESLKQMsVGEDLEcEDhDSRRYKYL.DDD...GSISPIEEStsEDE.sssph...cp.s.-CDIKLV-sopFIlSSEhPp.....	0	1	2	6
+15187	PF15334	AIB		Aurora kinase A and ninein interacting protein	Coggill P	pcc	Jackhmmer:Q9H7T9	Family	AIB is a family of eukaryotic proteins necessary for the adequate functioning of Aurora-A, a protein involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and aspects of tumourigenesis. AIB is likely to act as a regulator of Aurora-A activity.	27.00	27.00	191.40	185.70	17.90	17.10	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.13	0.70	-5.37	12	28	2012-09-03 10:14:07	2012-09-03 11:14:07	1	1	23	0	14	29	0	319.50	66	92.02	NEW	QTHLIKsuTKMLTLhPGERKspISFTQRphPsAGsRQTSIASFFTLQPGKTNGGsQ+SVSSHtESQhNKESKcDsTQL.DHLhQGLcDDChAsPLATSTPADIQEA.GLSPpShQ.sSGHHphtTPhLThhSL.QP-TL.VCAG-SKASLAhSFTQDlEsSCLLDQKEuc...DSShK+EWLpGSK.K.N.hQuhERHs+PsGGKsHQsLDKsKlE.KVSAKENRQuPV.lQTYR-.SaSGcNT.uVKQSPCPVslFSWDSE+sDKDSWSQLFTEDSQGQRVIAHNoRAPFpDVTNspNQGLGQFPsSPtAQsQtsssph.NLQPDLLFTQDSEGN	QTHLIKPGTKMLTLLPGERKspIsFTQRRsPssGI+QpSIASFFTLQPGKTNGuDQ+SVSSHsESQlNKESKKsATQL.DHLI.GLtcDCMuuP..LATSTsADIQEA.GLSPQSLQ.TS.GHHRhtTPFLT.L..SLhQPDTL.sCAG-SpssLAhSFTpDLESSCLLDQKEtc..tDSupKtEWLHGSK.K.N.YQuME+HsK.PGsKCpQPLsKTKLE+KVSAKENRQAPVhLQTYRE.SWsGENs-uVKQSPCPVSVFSWDsE+NDKDSWSQLFTEDSQGQRVIAHNoRAPFQDVTNNhNpsLG.FPNSPWAQCQ-c....ssp.NLpPDLLFTQDSEGN.	0	1	1	1
+15188	PF15335	CAAP1		Caspase activity and apoptosis inhibitor 1	Coggill P	pcc	Jackhmmer:Q9H8G2	Family	CAAP1, or caspase activity and apoptosis inhibitor 1, is a family of eukaryotic proteins involved in the regulation of apoptosis. It modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.	25.00	25.00	25.10	27.30	24.80	21.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.12	0.72	-3.77	14	90	2012-09-03 10:14:51	2012-09-03 11:14:51	1	1	71	0	60	86	0	61.70	53	16.01	NEW	shKPluhYIpDK+EMLcQCFpVlGEKKLpKMLPDhLKssolc-lccLCh-QLphlScKplh..pIL	...sLKPlSaYIsD++EMLpQCFsllGEKKLpKMLPDlLKssSl-EIKcLC.EQLEhLScK+lLpIL...........	0	13	17	36
+15189	PF15336	Auts2		Autism susceptibility gene 2 protein	Coggill P	pcc	Jackhmmer:Q9HAH7	Family	Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism [1] and with influencing the number of corpora lutea produced by breeding sows [2].	23.00	23.00	23.10	23.10	21.40	22.50	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.48	0.70	-4.30	17	176	2012-09-03 10:19:03	2012-09-03 11:19:03	1	3	48	0	86	152	0	197.20	53	25.25	NEW	KPGKWCAhHVplAWQIh+....H.QQKlK..QMQLDPHKL-.huhKhDhhSRPPuPulFsuhHaPpDLARP..LFSu...o.GuuHPussPFGPssHH.uuFL.PsuHL..DPFSRsuoFuGLGsLuSsAFG.....GLGs.sLo..ssSlFu.K-GP.slpsh...uuP.HEsWNRLHRTPPSFPT.PP......PWPKsuDsERsuusssH-tc..........R-s-K.........uK--+-..RDhL-KsR.Hss+uSP	....................KPGKWCAMHVpIAWpIY+....H.QQKhK...MQhDPHKLD.huhK.-hLuRPPu...Pu.......l..F....uu.......lt...aPpDL.ARP...sLF.S..u...s..G..A.sHP.u.usPF.GP.s.P.HH.usFL..PuuHL...-PFuRPooFuGLuuLuusAFG.....GLGsPols...ssSlFupK-uP...ultsF.......usP.H-.PWN.RLHRoPPSF.P..TPP......sW....KPs.-h..ERou.u.hss+D+-................R-s-+c...ph.sK-....-+-...R-.l-+p..h.s+sSP................................................	0	8	15	39
+15190	PF15337	Vasculin		Vascular protein family Vasculin-like 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9HC44	Family	GC-rich promoter-binding protein 1-like 1 or Vasculin-like protein family 1, is likely to be a transcription factor. The domain family is found in eukaryotes, and is approximately 90 amino acids in length.	27.00	27.00	27.90	48.40	22.40	21.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.33	0.72	-3.52	16	123	2012-09-03 10:19:58	2012-09-03 11:19:58	1	1	40	0	69	117	0	95.20	68	21.42	NEW	-s-hLSpSLEAEH.RLLKuMGWQEYsENDEshLPLTEDEL+EFphKoEQL++NGht+NGhLtp.pshs.hFssWRsoscschpcspDoETSS.S-TS.DDD	...............t.s-VLSpSLEAEH..RLLKtMGWQE.sENDEsChPLTEDEhREFQshoEQLp.+NGhpKNGhLps..hhss.hFuPW+sosht.s.-s..pDTETSS.S-TS.DDD.	0	5	8	20
+15191	PF15338	TPIP1		p53-regulated apoptosis-inducing protein 1	Coggill P	pcc	Jackhmmer:Q9HCN2	Family	TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localised within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.	27.00	27.00	66.20	66.20	23.40	17.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.68	0.71	-4.26	2	7	2012-09-03 10:20:35	2012-09-03 11:20:35	1	1	5	0	1	11	0	101.70	89	91.40	NEW	MGSSScsSFRSAQASCSGsRRQGLGRGDQNLSVM.PNGRAQTHT.GWVSs.LVLGAQVHGGCRGIEA.SVSSGSWSSATVWhLTGLGLGLS+PFLPGshVLRDRPLtSAhELSYDQKKA.LpLQ	.MGSSScASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSs.LVLGsQVHGGhRGIEA.SVSSGSWSSssVWhLTGLGLGLS+PFL.GshVLRDRPLtSAhELSYDQKKA.LpLQ........	0	1	1	1
+15192	PF15339	Afaf		Acrosome formation-associated factor	Coggill P	pcc	Jackhmmer:Q9NQ60	Family	Afaf is a family of single pass type I membrane proteins. Afaf is a vesicle factor derived from the early endosome trafficking pathway that is involved in the biogenesis of the acrosome on the maturing spermatozoon head.	27.00	27.00	91.10	90.50	21.50	19.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.32	0.71	-4.72	11	38	2012-09-03 10:21:37	2012-09-03 11:21:37	1	1	22	0	16	39	0	182.00	62	66.58	NEW	PANEKoGNYYKDIKQ.YVFTTQNPN.GopSEISVRAT...TDLsFuL+NaKhlstosh....tppusE-csshpEspcsphp+oT..PN.PAFWTMLAKAlNuT.ssp...--KDQLFpPIPsSDlNATsEDplu-Lp-lKLKLMLGISLMTLhLFlhLLAhCsATLYKLKpls.K.spES.QYSlNPELAoLSYFHPSEGVSDTSFSKSAESS	....PANEKoGNYYKDIKQ...YVFTTQNPN.GTpSEISVRAT...TDLsFuL+NaKhhNtTsh.....tpssptpt..pE.pcpp.pcsT..PN.PAFWTMLAKAlNuT.sst...--+DQhFpPIPsSDlNu....TpE.Dphu-Lp-lKLKLMLGISLMTLhLFVsLLAhCsATLYKL+plphK.sCES.QYSVNPELATLSYFHPSEGVSDTSFSKSAESS..............................	0	1	1	1
+15193	PF15340	COPR5		Cooperator of PRMT5 family	Coggill P	pcc	Jackhmmer:Q9NQ92	Family	COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyses the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.	27.00	27.00	93.50	93.30	19.20	18.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.17	0.71	-3.84	8	37	2012-09-03 10:22:24	2012-09-03 11:22:24	1	1	26	0	19	38	0	146.60	76	88.73	NEW	EAGhATADHSG..EpETEtAsDRLupGAQSlPs-sPs+GEGopuEEEGa...AhDcc-uDGEhNsWELs-Gs..ssPPpEpsus.lFNEDWDhELphDQGN..PYDADDIQGSISQElKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED	........AuFATuDHSu.pERETEKAMDRLApGAQSlPND.uPA+GEGTHSEEEGF...AhD-EDSDGELNTWELSEGs..sCPPKEQsuD.LFNEDWDLELKADQGN..PYDADDIQtSISQElKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED	0	2	2	4
+15194	PF15341	SLX9		Ribosome biogenesis protein SLX9	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NSI2	Family	SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences [1].	27.00	27.00	28.30	27.30	25.00	26.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.86	0.71	-3.67	125	252	2012-09-03 10:23:41	2012-09-03 11:23:41	1	5	220	0	174	248	0	135.90	22	65.24	NEW	psththoKK-....Kpph.K+ppFlpK....lpps..t.sp..........p....pp+p...++R........tpp...tls.s.....shcsLtcuL..Pp...........................................ttptth.pptt.....................hpppthst.........+p+cplh.ppEtpRFsplLsp.sa.................................................pssPhuAlcpalppsh	............................................................t..thh.oKK-....Kpph.++ppalpK....lptt....sp...................p....pp+p...++R...tpp.....tls.s...sLpsLt-uLP-................hp...t.............................tttp.t..ptts.............................hppp.hst....................+p+cplh.ppEppRFpplLsp.sa...............................................................pssPhuAlppalppp...........................	0	49	92	138
+15195	PF15342	FAM212		FAM212 family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NTI7	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length.	27.00	27.00	29.60	29.60	24.90	16.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.13	0.72	-4.36	8	105	2012-09-03 10:24:18	2012-09-03 11:24:18	1	2	41	0	47	82	0	59.60	62	20.65	NEW	Rs+P+SopsssL-phpuhs.ts-ucDWTooLhSpSRNRQPLVLGDNsFADLVtNWhDLPEss	..........................hP+Sps.ssshpphpuhc.hs-s-DWTooLhSRGRNRQPLVLGDNsFADLVtNWhDLPEh...	0	2	6	17
+15196	PF15343	DEPP		Decidual protein induced by progesterone family	Coggill P	pcc	Jackhmmer:Q9NTK1	Family	DEPP is a family of proteins expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels are found during the first trimester.  Its expression is induced by progesterone, testosterone and, to a much lower extent, oestrogen. The family is alternatively known as fasting-induced gene protein, FIG.	27.00	27.00	30.40	29.60	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.21	0.71	-4.68	10	32	2012-09-03 10:25:33	2012-09-03 11:25:33	1	1	24	0	16	26	0	159.20	52	85.86	NEW	GGPspEPP.......uSPSLDDYVRSICQLAQPTSVLD..cAsstspss+spR.PAp.............usEKSsPssSLQDITs+FSGQQPsLPtssTsDPLDWLFGESQEKQsS+RDhsRRTGsSAssWGsHRQhDoGKutusPRGRhC-ARsPGHSLuRhSpDtpQutp..Sh..suppstpssuSstpsRsSSlLRTLa.HLPVIHEL	.......GuPGQEPP.......sSPSLDDYVRSIspLAQPTS.VLD..cATApupPpsPaR.PAp................uscKupPAsSLpDlTs+FSuQ....QPsLPhssssDPLDWLFGcSQEKpsspRDhsRRTGsSus.hssHRQh-ssKs.sssRGRhs-A+hstaSLsR.spchpQs....S...s.tp.tpthuu..tsp.uShL+oLh.cLPVIaEL.............................	0	2	3	5
+15197	PF15344	FAM217		FAM217 family	Coggill P	pcc	Jackhmmer:Q9NTX9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.	27.00	27.00	85.50	33.40	20.10	23.60	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.39	0.70	-4.80	21	73	2012-09-03 10:26:04	2012-09-03 11:26:04	1	2	32	0	40	62	0	213.10	41	51.55	NEW	SDLSDSERls.lssSPhTPPDLsLRAEEIDPVphp...cPtpupsps-ahYPDFLPPPFNSWDL+chAlhhpoEshpsslPpssuhLtKYI-RLLQLEWLQhQTIQsEKsK.ss+uRssousus....ptshKSPG.+oKhhsusls.cs.s.hQ.p.Gs.sKsssp.....R.....KpshtppcscPshht.apsSspshchhus..oR....sS.+Qosph+p.....ctK++cssK.ss+.QphshsCs-...susKhposuNlRhPp	...SDLS-sE+hs.h..S.h...p.sDLNL+sEpI-sVp..............c....sh...ptcsp..a.YPDFLPPPFsohDL+chAl..poEshptsls.stu.lt+hIsRLLpLEhLQh.TlQpE+s+..hs.sp.sTssuo....pts.pS.u.psKlhtstls.csLs.hQ.p.us.sKot.p...........R...........Kps.tppchc.stht.aphSsts.chhhs..oR....sS.+posps+p..pppcssK.ssK..phhs.sCp-....SsKspsstshp.............	0	2	5	10
+15198	PF15345	TMEM51		Transmembrane protein 51	Coggill P	pcc	Jackhmmer:Q9NW97	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 253 amino acids in length.	25.50	25.50	25.60	25.50	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.68	0.70	-4.66	17	64	2012-09-03 10:26:44	2012-09-03 11:26:44	1	2	40	0	32	46	0	218.10	49	87.87	NEW	puuGSHYALsALGlGhlALGllMhVWslVP..Gtus..u.ssssssu.ss.ts..sss......tt+oKoSSVAaVLVGsGlhlLLLSlCLulRsK++pppst.p....ptpsss....pp.spppEc.t.-.tsupYsVPSYEEVlsost...ss..ppssh..ptspS...pLPSYEsLsshsp............spss.....s.....sssth.ssssps..........PsRpsSRsuRhL+PL+VRRIKS-KLHLKDhRlslt....p.ss..p.sslTIEPLTPPPQY-	................uNGSHYALTAIGlGMLVLGlIMAhWNLVP..GhSs..up+ssspu.N.po.suuG......hhKSKTFSVAYVLVGu.GVhLLLLSICLSIRcKR+pRQu--...chQptsussPpspcpcuQpE-....E-suuRYhVPSYEEVMsosh..sps..Rttpp..psphS...hSLPSYESLsulDE.................ssss.....ssputspssssps..................PsRpsS+..hu..++L+PLKVRRIKSEKLHLKDFRlsLs....s..ts..h.sPsoIEPLTPPPQYD................................................................	0	2	5	13
+15199	PF15346	ARGLU		Arginine and glutamate-rich 1	Coggill P	pcc	Jackhmmer:Q9NWB6	Family	ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.	27.00	27.00	29.20	30.20	26.80	22.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.29	0.71	-4.43	19	163	2012-09-03 10:27:43	2012-09-03 11:27:43	1	6	106	0	113	158	1	130.50	45	54.99	NEW	pEhEtKllEEEsA+RVEchlcKRVEEpLp..p-EIcpElpRRlEEu++th-cphht-lE+c+cttlp-t+p+EEcE+pc+E-LEclhpENpRKlEEAQ++.AEEchph.......hEEph+.hE.......-Rt+hcp-cc++h+-.E.....Qth...lLGKppoRPKLSFuL	...........pEhE.KhlE.EE.sA+RlEchltK+VEEcLp..p-EIcpEl.RRlEEu++hhccplhtpLE+p+pttlttt+t+.....E............EcE+pc+EELEchLEENpRKltEAQtKhAtEp.th.EEphp..E.......pR.+hcttcp+p.cc.E.....Qhh.....lLGK.s.p.....uRPKLoFsh...................................	0	37	59	85
+15200	PF15347	PAG		Phosphoprotein associated with glycosphingolipid-enriched	Coggill P	pcc	Jackhmmer:Q9NWQ8	Family	PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.	27.00	27.00	30.30	94.20	25.70	19.70	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.24	0.70	-5.38	5	46	2012-09-03 10:28:35	2012-09-03 11:28:35	1	2	37	0	27	40	0	401.30	61	99.17	NEW	MGP-GGLLSoGpVHIIlWGSLAAVuThLlITFLIFLCSSC-REKKPKQQNGDHENLMNVPSDKEVFSHSVTSLATDsPASSEQNGGLSNGDILSEDSTsAChQPYEEVQTSlSDLLEuQDSlGKSlKCHQSRELPRIPPNsTlETILSTRNsEsDQGLGMEGPYEVLKDSSSQENMVEDCLYETVKEIKElGAoAssEKupsG+us..uusAs+Es.uslsts+lESAEYASVDRNKKSRQSsNuESlLGNosDlEEEAPPPVPVKLLDENENVQEKEs-Es......EtpATEGsu-ssKRLSSLSYKSREEDPoLTEEEISAMYSSVNKPGQA.R..hsPESoYTCIpElAPpRSPSSCNDLYATVKDFENsPsu..ThPPu..u.RsNGEPEPDYEAIQoLu+DEERss.hPpos+lshspENDYESIGDLQQsKDVTRL	...........MGP.GuhLu.uGQh..Q..lsLWGSLAuVuhFhlIo.FLIFLCSSC.-REKKP+..p..puGDHENLMNVPSDKEhFS+SVTSLATDAssSSEQNGuLTNGD....ILSEDSTh.TChQHYEEVQTS.uSDLLDSQDSoGKs.KCHQSRELPRIPP-uAVDThLssRssDuDQGhGhEGPYEVLKD..SSS..QENMVEDCLYETVKEIKEVuAssp.-+G.....psu+u+.......Ss.sulKElsuPpsps+...s-F.AEYASVDRNKKCRQSsNsES.........lL.Gso..sDs........EEEuPPPVPVKLLDENENlQEKEs.tps.......EcpAsEsT.u.-ssK.....Ra.SSL..SYKSREEDPTLTEEE.IS.A.MYSSVNKP.G.......Q.....s.....h.....p......p.............ssES......s....YosIpt..sspRSPSSCNDLYATVKDFEKsPsu...ohPPA..u..RPstE.PEPDYEAI...Q...oLsREEEKss.tssu.ppshssK.ENDYESIGDLQQsRDlTRL.....	0	1	3	10
+15201	PF15348	GEMIN8		Gemini of Cajal bodies-associated protein 8	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NWZ8	Family	GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm [1]. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer [2].	27.00	27.00	31.30	31.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-4.28	39	92	2012-09-03 10:29:33	2012-09-03 11:29:33	1	2	65	0	64	84	0	197.70	35	87.38	NEW	psWaspssYu+.................YWpHYppAMtWhppHptA.hptthpthhssshhhsss.....psphsppstp.........................t.t....s....p.tttp.....t.pp.cc-t.-oco-sc.hcsDhs...NMElTEEL+QaFA.pTE+HREEh++.....QpQ...l-scp.-s..........YVpAD+sLhhs.h+.SspsPsEpPucpRpAE.MK+LYG.cuAs....KI.AMEsAlQLsFD+pC.Dc+pPKYWPlIPLKh	.......................................................................................Whtp.hatc.......aWpHYppAhtWhppHp....p..ht.hht.shhhs.s.....psphsppttt...............................................................t.tp...t..t.p.ptpp......t.pp.c--.-o-SDs-.lEsDlo......NMEITEELRQYFA.pTERHREEh++......QQQ...l-scchcs.....................YVsAD+sLhhstp+..SspsP.sEcPu..c+RpAE.MK+LYG.csAs....KI.AMEsAlQLoFD+ps.DcKpPKYWPlIPLKh.....................	0	18	22	40
+15202	PF15349	DCA16		DDB1- and CUL4-associated factor 16	Coggill P	pcc	Jackhmmer:Q9NXF7	Family	DCA16 is a family of eukaryotic proteins that interacts with DDB1 and CUL4A. The family may function as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex [1].	27.00	27.00	349.80	349.70	20.50	18.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.68	0.70	-4.98	2	16	2012-09-03 10:30:57	2012-09-03 11:30:57	1	1	14	0	8	12	0	207.10	95	100.00	NEW	MGPRNPSPDPLSESESEEEtNANYLNESSGQEWDSSEtEDPVVPNloPLESLAWQVKCLLKYSTTWKPLpPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVP+LEPIPEWPPLASCGVPPFQKPLpsASRLSRDHATLNGALQhATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVN+LLTASL	MGPRNPSPD+LSESESEEEENhSYLNESSGEEWDSSEEEDsMVPNLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGALQFATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVNKLLTASL.....	0	1	1	1
+15203	PF15350	ETAA1		Ewing's tumour-associated antigen 1 homologue	Coggill P	pcc	Jackhmmer:Q9NY74	Family	This family of proteins is found in eukaryotes, where members are expressed at high levels in the brain, liver kidney and Ewing tumour cell lines. Proteins in this family are typically between 648 and 898 amino acids in length.	27.00	27.00	75.90	40.40	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	814	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.85	0.70	-13.37	0.70	-6.52	8	53	2012-09-03 10:31:34	2012-09-03 11:31:34	1	2	34	0	31	50	0	614.10	41	89.43	NEW	RYETPKRlLKMDLLSSTFSSP.NDPDGQNDIFWDQNSPMTKQLGKGRKKQIYoTDSDEISHIVNRIAPQDEKPTTNSMLGhWIGETAIPCTPuVAKGKSRAKlSCTKLKTQNQEEELMKLAKQFDKNMEELDVIQEQDKRNHDFIQMISEsETLNNYKDNVQMQhLp-I...VPEIDsuIIKKPhKtNTKISVs.NDQsSSQKPFDQNAEAAFNAIFDGSTQKCSGQLSQDLSDAFLNTSNTTFGKKssLKEEKIIoNETlVTE+L.NK.......TPsSLSsQVDTPsMTKSCVTSsTKEPcshsKalDsFsTSDFEDDWENLLuNEPFVMQNlEhsELhP.u.KTsQhsDQKuICoFN.uKNDKSKSthNoSLDsRLRDSKILQDLPScTpNpELhDAtKapF.P...sPNDKPNKL.S.TGNKhKFEKSFNKlVlQDKIQD...sAlASsLTKVKEDhpT...K...Fs...ss..SpKKSuLNTGYSN-Q.......KNKsIFNQSFKsPAslcPFGSAsLusET.SVsNsNQTNASKLsSFFDDWNDPSFANElVKACHQLEsTWEADDVDDDLLYQACDDIERLTQQQDlRKDSKTSEShL-lNNSSpHGA.KNhFTTSKQuSQLlQSKHLNLuSISsp.T.SlTNSSQlsKSVKMEKGEhCGNSPuFLGATTNLoIYSKNSssQhsN..VuhNNTcVPlQVNSSKSlLsGSSSLNVsSDHMoTEIATspKKLSTppLSHsTlTDEuQocLN+sV+hSKYTFTKhKNsQhhSQhNQNCl.sGSlSDTKIoQsLEKNK..T..VNsLhGcAVQQQSLh+.hSESLKQPSKEEEEKNRKYSPEEIQRKRQEALVRRMAKA	............................................................................hcTPKRhhphchhSss.FSSP.NDsDsQp-IFWD.sSPhTppL.GcuR.+KQh.hspsosEIScIVN..RIAPQDEK.Ps.s..s..ShLshWIG-sAIPCTPsVsKtKSRsKhsss+.h......K.spspEEELMKLAKQFDKNM.ELDslQEQspcsasFhQhhSEsthL.ssa+D.shphp...shpsh...lsEls...ps..t.cshctso.pluh...pspsSSQKshD.sAEAAhsAlFDGSTQKCSGQLSQtLs.-s.hssopshh..hcpss....LhcEp........st....cohl...-ph.sc............oshulos......psDoshhspSp.lT....ppc..s....t.h.c.....s.....hsssDF-DDW-..s.hLss-sFsMQ.sp.sELhss..cosp....s.....ppth..ht..spsspshsthsts.....th.htssp.h.shsSph.stph.ss..p..h..pst.c...pl....tNp.ph.pps...h...sch.p...h..stshpphpEs..hs.p.........s..stccsshspt..sppp.......ps..s.h....pshpsssphp..sShtlspps....thsp.spppssK.s.s...aDDWNDPphusEllcthpp.-shW-u.sD..DDDLLYQsCDDlE+LTQpQshpcssctoEs...hs.sS.pGt.ps.hshScpt....p...hhQs.cHh....N.ssh.Shp.h...o.hpps.phsK.hthp.c.t.htsssp.hss.pNLoh..t.ss...p...h..sssssshthstop.hhstp.s..h....tpsthtsphs...pphpsppLstpshsst.sp..st.sp...st.s.casFp+hKssp.h.phsps.h.ssphs.sschh..pthtpp+..s..ls.shhtp...s......pp...h+..hSESht.ssp..t..pEE+N+KhS.EEIpRK+QEALsRRhu+.......................................................	0	2	5	13
+15204	PF15351	JCAD		Junctional protein associated with coronary artery disease	Coggill P	pcc	Jackhmmer:Q9P266	Family	JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells.  The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localises close to the apical membrane in epithelial cells. This family is found in eukaryotes.	27.00	27.00	191.40	27.20	17.50	17.20	hmmbuild  -o /dev/null HMM SEED	1356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.15	0.69	-14.27	0.69	-6.96	15	60	2012-09-03 10:32:28	2012-09-03 11:32:28	1	3	35	0	36	53	0	1002.50	39	97.42	NEW	MYSVEDLLISHGYKlSRclPAP+E-ch-G+ppARocsRAGpG.LLNGCEDGsAAhspSK....suhG+GalS.soE......s++p.sPRuHsEsQS.sSAuRsSEuGFYcQPsLsWSSQPQoucDpAY.RRR.GQ-sSu.lLGPRDR--LEsRGMAQAHSLPsHsREGPWEVGGRTEpVMKKAVWEEELRMuGPuKWQNlSLESWNQPRKLGRQMSDGDGEKLFQD....LYPFhpGEcsLsSQsKGKSQSLPRVLSPESLSChEIPIPLNDGHhPuVPKMPsYPPNCAPsLEsTRNsEKuGSSsPLPRPKFGRPLKPPS..YsSHppSRuGsEsSchpDSpQsD...hsssh...sppP.RpEhsssDsGLEPPVYVPPPSYRSPPQHIsNPYlE.DssP+sVsuGppQQpps...sE+suAusplPuGshuoGsEYGAusp.SPpGh.spPRPsssa-uSVQYIPFDDPRIRHIKLApPpGFs--sKh--psYsuuPlsssEPApGptQpDGAlhsPpulssssGsERu....ssh.AsPSPpWLWGQLPRDuENuGhPDQRDHCss.RGQ.PsspGSp+t+sEG.VSSPsPQ.GESTCETpTKLKKFE..TGhQTKKSSKKKhNETIFCLVSIPVKSESHLPDpDpNNNDLKQSADKKNGhDKSsALQEQSLLSMSSTDLELQALTGSMuGRTEhQKQ-LGEPE-sKQTNDLRFIHPsKHRELKYSGSWPGHQYRDQQTQTSFsEESKSsQhLPupKsGuss.cssLoP+psDP.......sA.S-.sphHsALuSSDpsQRPsAhsLKGQhS.LSPSSNSAFSRTSsshsQAPsPKAupoQP...shDspG+suuPsP+uEVVKGEo.T.GPCNS+QLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESusSS......SsSuSE....-S-sEhppEspAssps+shGhpcsSt-hRsctts+tls.EcPsh+SGRVKSKSESWSEE.csG..aspupP.S..GsspstsGRGpshhsAcGSLlsEp+cQEscsRhschslSPuPV+R.h..SSRu..SDs+PsssupsAE.REPQEspcLss.....shsSVplSpuuPPcssuutERuo..slsLSLuuKsRGLSAPDLRSVGLs.u.EpSAscLDGSLG-AsAIEIPP..NESLQARAARILGIEVAVESLLPGspRsGQsQsPEPDuSApssEuPREE.osuSsA.ss..sPososDAFYGRRKCGWTcSPLFV..GERDushRuP.AsE....pSsVDuslsSpsssPEPpPss.EspshppKDhts+PPFRSTLFHFIERTPoVuGSEKRLRSTSKVIESLQEKLASPPRRADsDRLMRMKEVSSVSRMRhLSsRSADSsEEAEELKA..RG.us.PtG.sohssuDhup+sGpssulSKGslSLEEsGHPAupR.EKs.scQDFWCP	.........................................................MaSVEDLLlSHGYt.....spp.s...s............th.........t..t....u.t...NGh..........................t..t.ssp......tt..................................thhpps..hhsup.s..tps.hh.hpR.ttp...u...t.p.t.tt....t.tthut.s.uhshp.......+Eu.h-VutpsEpVh..+pshhp-ph+hss.t+WQslshESWppP+clGRQMSDGsGE+hhp-....LYshh.u-pslsopsKtKSpSLPRsLSPESLphhElPhshs-ta......sKhs....as..Pspsssh-.ss+p.c.pssp.sPhP+PKFGRPLKPPS..Yp.pppoRussc....s..pDpp....phc...............sRp-hsh.D...s...G...LEPPVYVPPPSY+S..PPp.ph.ssPah..stsPh.hssspppQpp....hE+stsst......ssss.ususphssssp..P.uh..pP..p.ss.sasu.VQYIPFDDPRlRHhKlApstsh.hp-hchtcp.hss.us.ssst-sshtthp.cuAhhs.spshhs.sssp+u....ss..sss..SspWLhst..stss...Ess.uhPcQR-ps..ss.psp..Pss.psu..ptpstt.sos...sp..u-u.....o.CET.TKLKKFp..TG....hpoKK.SS...KKKhNETIFCLVSIPVKSESpL...PD.pDpNNNDLK............us-..ppsG.cp.s.suLQEQ.SLLShS..STDLELQALT.GSMus+schp+QshtcPctt+QssDLpFlc.sKHRELp.aSGSWPGcQYRDQQTQTSFsE-sposQ.hPus+.Gtss.sss.oPp.t.-s...............................ss.oc.sthpsuhsssD.pp+spu.slKGQhS.LSPSSNSAFSRTS.shsQuPhsKus.uQs............th.s.pt.sspPss..+tEVVKGEs.s.usCNSppLFGQFLLKPVSRRPWDlISQLESFNKELQEpEESpssu.....p.sssE....-u-tc...p..shs.st.cs.t..t.t.t.cht...thhs.-tPshpsGRhcspSpSWS.cc.p.s..t.ts.....hs....s..p.ttutu.sh..spush.s-...ptp.-..pthpp.shp.shPs.c.h..u....stps.s.....t.+.stt..c..t......ht.sp.ut.s.s.p.sth.ptts...h.LsLss+spGhStPDlpsltL..s.t.ts.p.....s.tsshEIPs..sESLQtRAsRILGIEVAVESLLPsstp.sttp..stsssssht.tsstpt....t...s.....th.tsua.uRRKCGWTcSsLFV..G-.......hs.t.......sthpt..ssp...PE.............ps.t.......sPh+uslh...phh-+ssss.ssEKRlRssSKVIEoLQtKLsSsPp+ss.-RLhRMKEVsSlSRMRhLS.+ss-S.--s-t.K.........................t............tt.t.................................................................................................................................................................................................................	0	1	7	15
+15205	PF15352	K1377		Susceptibility to monomelic amyotrophy	Coggill P	pcc	Jackhmmer:Q9P2H0	Family	This family of proteins is associated with a susceptibility to monomelic amyotrophy.	27.00	27.00	32.60	32.40	21.20	23.00	hmmbuild  -o /dev/null HMM SEED	982	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.99	0.70	-13.80	0.70	-6.61	18	67	2012-09-03 10:33:30	2012-09-03 11:33:30	1	3	37	0	32	60	0	648.90	38	85.13	NEW	QQRKQKFEEVTEKFQRAHlPhSQRRRu...Va....QKPVPPLEEALKQIQcSsLKSElNL.PsS+RPTlNWRsI...DsAL.PSuLS+N-a++Q+pLhS+l...sC-KEMpENs+ssLsos+.ssFQLKLEETQ+LLEDQ.HLSsLQ+Fp-E.VNQITNSETLSSIDSLEAGE...+.EEIYlTL.sKEs..SoSsQ.pNo.lSLcS...u.NlQSsN..hsCFDcDKLsaSKTQ.HINNWLpNLcspNTQosoPFoDILuKsNVL..PshEa....hNuKEQNs..sshspss-..RsTsTu.sNoluFV.pSPssFlpscKsE+sSEoSohpoTDu.oStsFK+E+PhVTESPsFKFSKAWsTPDSlTpEhsphSDQE+hSElTQcNRTTSl.TShlPhATPLlL.Po...........NpQSu.+sLsKsslH.lKEIcPlQ..CSDpLsELcDhKDE..+lKahssscccLP.LFSDshpsuhl...sp...Ns-scD.cKp+.hscTu.oL.SshhSNhDLVuQHKKhKaNIaERNGV+FLKSILKKESKYEHsYhKALllNpGhphGNQKAAAIRDSIELTK..cKGcsuEIsKT.IKKLRWFDEsuph.cpss--spSLKNpstlopQhSQ.hH..sp...SuAsSNlhSlPAsAlNSAsscpsK-............s.u.lS.csssslGtSspDpVPLNsF.lPSGYshAKQAW.sSK+EEu+sPV+.s.DSKsQKssPQRGtsKlIRRs+SAKVQSu.hlppsRK..GTllRPQSAS+AsshlQsQGKLllPHPPP+ssoN.RuuKshpsSp.CQsVhP.-sSQN.hhTp.ssh.NS+alLPsEaplNphsQESS.Pl.sssC.SDhVTVhPSLP.YsoSECpTlAK.lNaS.susQslApQDuolaCT.pRsPVhEEuh.oloL+sT-EEsssLWK+t+ssLsQN-+uADS.TVsRRKpIl...EN...KpRsLLEQKRQssGSlupKasEQhsNFup....oVpLSSSEPKQosRGTSsh.EEVS-STSpFLMAENLVKuSVPEDEILTshsSKQhpKssLsLNKTQph.NICALSAEEQKILQSLs+LNERLa	..........................QQR+p+hpEsTEpFQRAHlP.SQR+p.s...s.....p+ssP.LE-ALcQIptSs.lp..hsh...tp+shh...sh...cps...Sshsp.t....pt..t.....t.pc.hpEs.hhslsspp..hFp.pLcEhQphLccp.Hlsslpphpc-.lpphspSEoLSSlDSLEss-...p.pp.h.oh.s.p...u.shp..sp.h.hts.....p.p.tp...sh...h.ts.hthu+st...pph.hshts.sspss..ht-ll.K.s.......ph....hpspctps..s..pt.hp..t.hss..sst.s.s..p...h..shpt..tssp..th..st.............hst....p.s+s.sssp..s.th.....pt...p.p..pt......s..s.h..hhL.ss...........s......t...pt.h....thps....s.sthtph..hppt..php.hps.ttt....h.s..ps.............p..p.pt.....s..sh..t..st.s..tp.p..p.s.hc.pts+hl+uILKKcu+.c.s.h+slhhspth.htpp.stsl+DSlELsK.+t...E..+s..+KL+WhDEht........ph...t.t.tt..psh.t.......................p......ts...tp..t................h..p..........ttp....s.h.hssG.p.s+pAW.sst.tt.......ttsp..pt..pps..+hh+psts..s+sp.s..h.tpp+..ssh.p.QSspcsp...tsQu+h.hPpPP.ts...............................................t..h......ps.......s..s...s.....s....s......p......p.......ppt............tpt...............................s.....h.p......t....p.t.l.pQ++p.st.pht.+.....pph......sh......ss.p.Phps.ps..h.....tplS-STspFLhAEpLsptshsEscILshhpshp.tp..h..ppstp..sh.ssLShEEQ+lLpSLpcLNpRL.......................	0	5	9	16
+15206	PF15353	HECA		Headcase protein family homologue	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9UBI9	Family	HECA was characterised first in Drosophila where it regulates the proliferation and differentiation of cells during adult morphogenesis. In humans, HECA affects cell cycle progression and proliferation in head and neck cancer cells. It by slows down cell division of oral squamous cell carcinoma cells and may thereby act as a tumour-suppressor in head and neck cancers.   	27.00	27.00	31.10	31.10	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.34	0.72	-10.86	0.72	-4.34	14	102	2012-09-03 10:34:47	2012-09-03 11:34:47	1	4	77	0	66	93	0	102.00	54	20.64	NEW	hstCCsPhus..............p.tt.hphschpss.....+VhCsNEpCst.upaMH+pCF-tWEpslLs......hL+ohGRARSWS-+QRpQNLWTKKGYDLsaKhCuC+CG+GpL+KDh-Wh	......................................s..CssPhhs..............shhtslchpc.cDh.KVlCNNEpCPh..upaMHhpCF.cWEuolLs......phps.....hGRA.RSWsEKQpRQNhWTKKGYDLAF+hCSCRCGpGHLKKDhDW.h.......	0	17	22	45
+15207	PF15354	KAAG1		Kidney-associated antigen 1	Coggill P	pcc	Jackhmmer:Q9UBP8	Family	KAAG1, kidney-associated antigen 1, or RU2AS (RU2 antisense gene protein) has been found in mammals. It is expressed in testis and kidney, and, at lower levels, in urinary bladder and liver. It is expressed by a high proportion of tumours of various histologic origin, including melanomas, sarcomas and colorectal carcinomas.	27.00	27.00	88.30	88.30	25.00	19.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.95	0.72	-3.65	2	9	2012-09-03 10:36:12	2012-09-03 11:36:12	1	1	9	0	3	2	0	79.60	84	100.00	NEW	MDDDAAPp.EGVPVAVHpHALH.tLRQVsGPGAuAsHLPRhsP.pLAAs.t.AP.LSQhPHRTpGAGSsPETNtp.TNPpV+EK	MDDDAAPR.EGVPVAVHKHALHDGLRQVAGPGAAAAHLPRWPPPQLAAsRREAPPLsQRPHRTQGAGSPPETNEKLTNPQVK....	0	1	1	1
+15208	PF15355	Chisel		Stretch-responsive small skeletal muscle X protein, Chisel	Coggill P	pcc	Jcakhmmer:Q9UHP9	Family	The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.	27.00	27.00	82.10	74.60	20.30	16.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.02	0.72	-3.97	9	43	2012-09-03 10:37:14	2012-09-03 11:37:14	1	1	39	0	28	31	0	84.40	77	98.29	NEW	MSKQPuSNV+ulQANINIPMGAFRPGAGpPPKRKEhTsEs.Eps.P...sstt.EEKK.lPGAhKLPGPAVNLSEIQNlKSELKaVPKAEp	.....MSKQPsSNVRAIQANINIPMGAFRPGAGQPPRRKEsTPEs...EE.u.s.P.....PTo-.EEKKPlPGAKKLPGPAVNLSEIQNlKSELKYVPKAEQ..	0	1	3	11
+15209	PF15356	SPR1		Psoriasis susceptibility locus 2	Coggill P	pcc	Jackhmmer:Q9UIG4	Family	SPR1 is psoriasis susceptibility locus 2 protein family.	27.00	27.00	123.90	123.70	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.10	0.71	-3.73	5	32	2012-09-03 10:38:06	2012-09-03 11:38:06	1	1	23	0	15	26	0	113.20	79	84.46	NEW	SpDHPSPPusEA+EEsuuPTLPQGPPIPGDPWPGAPPLFEDPPPPGPSRPWRDLPESGVWPPEPPoTDPPQPPLPDDPWPAGPQPPENPWPPAPElDHcPQcEPDLDPPREEYR	....StDHPS.sssEspEEtGSPTLPQGPPlPGDPWPGAPPLFEDPPPPGPSRPWRDLPEoG..VWPPEPPpTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDHtsQEEPDLDPPREEYR..	0	1	1	1
+15210	PF15357	SEEK1		Psoriasis susceptibility 1 candidate 1	Coggill P	pcc	Jackhmmer:Q9UIG5	Family	This family is considered a candidate for susceptibility to psoriasis.	27.00	27.00	28.40	32.70	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.95	0.71	-4.30	3	13	2012-09-03 10:38:49	2012-09-03 11:38:49	1	1	6	0	1	14	0	128.30	85	94.99	NEW	TDQKSHSQRALCTQTPALQGPQLLNTDPSSEETRPPHINPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKsRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTsAPTLLYSPPPSHSPFGLSSLI	...TDQKSHSQRALsTQTPALQGPQLLNTDPSSEET+.P.l.PDRLCHMEPANHFWHAGDLQAMhSKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRT.APTLLYSsPPSHSPFGLSSLI............	0	1	1	1
+15211	PF15358	TSKS		Testis-specific serine kinase substrate	Coggill P	pcc	Jackhmmer:Q9UJT2	Family	TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ [1]. Recently it has been shown in human testis to be localised to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function [2]. TSKS is localised during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis [3].	27.00	27.00	87.10	87.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	558	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.87	0.70	-6.35	3	39	2012-09-03 10:39:39	2012-09-03 11:39:39	1	2	26	0	19	39	0	447.70	73	95.07	NEW	ESRopLuPEsPGusooPsKGhsKKKKAVSFHGVEPRMSHEPM+WCLNLKRSSACTNVSLLNLAAsEhsDSosp-oTTDD..PshsASGspSsPl...PPuuPo.sWAsDDPDIo-lLsGVNSGLLRAKDSITSLKEKTTRVNQHVQoLQSECSVLSENLERRRQEAEELEGYCoQLK...........ENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRFLQRQLQDEsPRRQEuELQELEQ+L-AGlSRpsLuhousSouss.sPPsSE-cPsPP.........cuLulAthsupsRAGEGsEVS.pEhQKVoAGL......EELR.........REVSSLTARWaQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAARGLQELRGRADELCTMVERSAVSVASLRuDLEGLGPVKPlLEELGRQLSSuRRGS-LSMsLDR..sGSCuRCuSQ.GQQLSTESLQQLLERALTPLVDEVKQRGLA.PACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKVAoLDYLHLKMCSLHDQLSsLPLEGSssohGGGSuGGAPPKRGGPsPEQ	................................SpsQLsPEsPtusos.sKGIsKKKKAVSFHGVEPpMSHpPMHWCLNLKRSSACTNVSLLNLA.Ah..Es.DSoGTDSTsED........SG.hsLss...PPuSPo.PWss-DsDIoElLSGVNSGLV.RAKDSITSLKEKToRVNQHVQoLQSECSVLSENLERRRQEAEELEGYC.QLK...........ENChKVTRSVEDAEIKTNVLKQNSALLE...........EKLRYLQQQLQDETPRRQEuELQE.E..............Q.K....EAGLSRpGLuPss.s.GCs.GPPGSP-cPsRP.........RuLsPuGWGMGsRAGEGPhlSEQ..ELQKV.sGl......E.ELR.........REVSSLTARWHQEEGAVQEALRLLGGLGGRlDGFLGQWERAQREQAQTARGLQELRGRADELCTMVERSAVSVASLRSELEGLGPlKPILEEhGRQhQsSRRGsDLSMNLDRu.QGsCuRCASQ.GpQLSTESLQQLL-RALTPLVDEVKQRGLs.PACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKhAsLDaLHLKhCSLHDpLSpLPLEGSTGoMGGGSuuGsPsKpGG.ssEQ.....	0	1	2	5
+15212	PF15359	CDV3		Carnitine deficiency-associated protein 3	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9UKY7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 251 amino acids in length. CDV3 is also known as TPP36 - tyrosine-phosphorylated protein 36. The function is not known.	27.00	27.00	30.90	30.00	25.60	25.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.82	0.71	-4.06	9	101	2012-09-03 10:40:36	2012-09-03 11:40:36	1	1	63	0	53	93	0	118.10	51	57.56	NEW	KE--EWKEFEQK.EVDYSGLRlQuhQh..sEKE--EsEK+--.t-shEEsGth........uuDKSSGPWNKSA.A.sPsAssh..VpEs.EP.spsuGVYRPPGARhTs.pRtssQGPPEIaSDTQFPSLQSTAKHVEoR	.............---EWKEaEpc.chDYSGL+lQshQI..s.EKE---s.EKc.p-.su-sh-EsGus.........Gs-Ku.S..G.PW.NK...........oA.s.......s...pAPsussh.......VsEsP.cP...sh..TuGV....YRPPGA......Rhos............sR+ss.........Q...G...P...PEIaSDTQFPSLpSTAKtl-oR..............................................	0	13	17	31
+15213	PF15360	Apelin		APJ endogenous ligand	Coggill P	pcc	Jackhmmer:Q9ULZ1	Family	Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control [1]. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes.  It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis [2]. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis [3].	27.00	27.00	27.00	27.00	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.76	0.72	-3.75	8	19	2012-09-03 10:41:47	2012-09-03 11:41:47	1	1	18	0	11	19	0	54.80	67	72.82	NEW	GPLhpssDGK-LEE.GolRpLVQP+suRsGsGsWQGGRRKFRRQRPRLSHKGPMPF	.GPLhpssDGpsLEE.GNlRaLVQPRsuRsGPGsWQGGRRKFRRQRPRLSHKGPMPF	0	1	2	3
+15214	PF15361	RIC3		Resistance to inhibitors of cholinesterase homologue 3	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z5B4	Family	RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.	27.00	27.00	27.10	27.30	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.10	0.71	-3.98	27	152	2012-09-03 12:43:49	2012-09-03 13:43:49	1	4	75	0	80	140	0	158.40	28	37.52	NEW	lVL.ClulllP+hh.....hsts....pp.....p..............hspssssphsPhhp........tts.ss..ss.t...ss..t.s+scshcuhspscsts.tt.ts.....supppuhhupllPlYuhGllLallYhlaKl.p.+scp..p.ppppps.............................s.t...........pss.........t...+pc..hs-hcLspLQ-RLppTEchMppIlo	.......................................................................................hhs.............................h..hths...P.hhc...........................pts.ss...ss.s..sthh.tRst.h.uht.shGuu.stt.ts............tsptpuhhG..lhP...l...YshGIllahlYhLhKl..ptKp..s.pc.ttss..............................................................................................tt.............tp...........hcpt...sphcLtpLpp+LppTEptMppll.s................................................................................................................	0	16	26	50
+15215	PF15362	Enamelin		Enamelin	Coggill P	pcc	Jackhmmer:Q9NRM1	Family	ENAMELIN is involved in the mineralisation and structural organisation of enamel. It is necessary for the extension of enamel during the secretory stage of dental enamel formation. The proteins are expressed in teeth, particularly in odontoblasts, ameloblasts and cementoblasts.	27.00	27.00	34.50	34.50	16.30	16.20	hmmbuild  -o /dev/null HMM SEED	906	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.82	0.70	-13.77	0.70	-6.46	36	250	2012-09-03 12:45:25	2012-09-03 13:45:25	1	2	199	0	21	246	0	720.00	60	93.29	NEW	PYYSEEMFEQDFEKPK.EcDPPKsESPs.TEPouNSTVsETNSTQP...s...sGGSQGGNDTSPTGNss.G.NsGsNPssQNGlhssPsVNlSG...QulPRSQIPWtPsQPNIaENYPNPN...lRsFPsGRQWpPTGTshGpRQsGPFYRN.psQRGspWNSFAhEuKQsA+PGNPsY+KsYssToRuN...PNaAGNPANFRRKPQGPNKpshGTNls...PluPKp.GTls+sEKlQNP+EKsl.GQKERhVhPT+DPoGsWRNSQsYG.lN.KsNYKL..PpPEGNh.lPNFNSlDQ+ENSYYPRGDSRRsPsSsuQsQoQNh.PKGIsLEPRRIPYEoETspPELKHuTapP.hYPEEIPSPsREaFPsGRNTWNcQEISPsFKEDPt+QEcpLPa......PShGSRGsVaYsEYNPYsPR....ENSPYhRSNTWDERsDSPNTh...GQPcNP.Y.PhN...TP.D.QK-TlsYNEEDPlDPT.GDE.FPGQs+WG.E.E.suFKtuPTVRaY.EGpQYs...S...NQP...KEYLPYSlD.NPsKPREDhPYuEFYPWsPDEsFPSYNsuPTloPPsEsRGYYs.NNAltQEESolFPSWNSWDa+IpsQuQKE+pPYFNRNaWDQuTNLHKsssssPsQKENpPYSSNsPAGLQKNPTWpEG.EN.LNYsM.QITRLNSP-+-HLuFsDllPQsYPssQcEsaLFH..SQRusCCAGuSsG.+D.NPLALQDYTPSaGLsPGEsp-osPhYTEuSHTKHARalISPTSILPuQ..RNSSEK+L..PGESQs..P..FRDDVSTL++NTPCSl+sQlGQtGhh.sFPEAuSLQSKNTPCLKuDLuGDGNN.lLEQIFEuNQ.lNERTl.sLTPEQLlIsTP-EuPKPEuIQSEl.QGsEGE+QQpR.PPSILQlPCFGS+LsKa+sSSTGTPSopGRpGsaDGDssMPTEpP.sTLsGLATGEQFpulNVD.LNA	...........................................................................PYYSEEMFE.QDFEKPK.EcDPPKsESPs.....o-PosNoT..ssETNSTQs...s...stGuQGGNDTSP....TGsss...u.NsssNsssQNGl.s.PsVNsSG...QssPto.QlPh......t..PuQPNIaEN.aPNPN...hRsFPsGRQWp...............TGo.shGpRp..suPFYRN...........sQRu..pWNoaAhpuKQs.s+PGNPhY+KsYsss.uRuN.....PNaAGNPuNhR...R...KPQuPNKpPh.sTNs.u...sh.uPKp.s.T.ss+sEplQNP+EKsh.uQKERhlhPT+..sPousWRNSQpYt.sN.K............sNYKL..P.PEush.sPsFNSlDQ+ENSYYPRsDS..R+sPsSssQhQsQNh.PKGlhLcP+RhPaEoEsp..pPElKHuoap.P.s..............Y.......sEthPsss+EpFPs.G+NTWNpQE..ISPsFKEDPGRQEEpLPH......PS.hGSRGsVaYP-...YN.PYsPR....ENSPYhRuN.oW-ER.sDSPNTh...tQscsPhY.PhN...TP.D..KcTlsYNEEDPlDPT.GDE.FPGQsRWG.-E..SFKt..sPTVRaY.EG.cQYs...S............NQP...KE...YLPYSLD.NPsKPRED.FPYuEFYPWsPDEsFPSYNsuPThs.PPsEspGYYh.ssA.htp.E.Eus.h.PSWsSWDp+hpspspcEptP.YasRNhWspsspLpKs.sp.spQ+cNpPYsss.PsG...LQ+NPhWpEu.Es.LNYsh.QhsRlNsP-tpp.sF..-hls.sYPssQpEuphFH..SQRusCCsGushG.+-.s..PLALQDYTPuaGLsssEst-ssPhYo-sSHoKasR.hlSPsuh.ssQ..RNSSEKp......tEsts..P..FRDDsuoL++ssPCShps....plsQhthh.shsEssS.Qs+NhPCL+sDLuGDGss.lLcplF-ssQ.hsERTs.sLsPEQLlh...ssP-EsspPEsIpsEh.ttpEschpQpR.sssIhplPCFsSplsphhsSosGsPsu.uR.sshst-.h..hPTc.P.sohstLATttphpshNlD.ls.......................................................	0	1	1	6
+15216	PF15363	DUF4596		Domain of unknown function (DUF4596)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9UPP5	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.	27.00	27.00	37.00	37.00	25.90	18.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.28	0.72	-4.04	10	87	2012-09-03 12:47:34	2012-09-03 13:47:34	1	3	38	0	49	63	0	45.80	71	4.71	NEW	-ThuRWuELhSPLDDSosSl.T.VoSFSP.ED.ssSPQGEWTIlELETaH	...pLuRWuELhSPLD-SpASI.T.VsSFSs.-D.suSPQG-WTllElET.H	0	3	8	19
+15217	PF15364	PAXIP1_C		PAXIP1-associated-protein-1 C term PTIP binding protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BTK6	Family	This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localise at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length [1].	27.00	27.00	42.40	42.00	24.70	24.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.17	0.71	-4.27	21	81	2012-09-03 13:14:09	2012-09-03 14:14:09	1	1	71	0	53	71	0	129.70	44	61.23	NEW	-WplssSD-Eh......................sW.PsPpEItcL...Ychl...spstsLELpaps.sRRs....PoPp.tsp..csppsp....pttctt.-pcs.ps.oEFDF.DD-.s..p............sphhsRRpssuo..ttSspK+pAphDcVLscM+RH+..........+l.ppthpps	....................-WslsCSD-Eht.s......p..................sWhPsPpEIpcL...YEhL...sspssLELQhchhsRRs....PoPEspsptpcs-c......cscEpt.Ec+PphP.oEFDFDDE..s.osp..........sshhsRRRTPGo..ss+Sp.KRpA+hDKVLSDMKRH+..........+l.pppI...hcp.........	0	16	20	35
+15218	PF15365	PNRC		Proline-rich nuclear receptor coactivator	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NPJ4	Family	The PNRC family, proline-rich nuclear receptor coactivator, is found in eukaryotes, and is approximately 60 amino acids in length. There is a conserved YAG sequence motif.	27.00	27.00	27.10	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.06	0.72	-3.96	36	209	2012-09-03 13:16:56	2012-09-03 14:16:56	1	1	132	0	140	210	0	56.20	38	22.51	NEW	ssssYAGu+FopsPsPosLPhPP.cWhtsss....................p..shpthop.............pL+tlL.clp	....t.tppYAGup.F.us.sPuPSsLPhPs.ahhsss..............................................t.stp.hs.........................................pL+tlL.pl.......................................................	0	27	56	92
+15219	PF15366	DUF4597		Domain of unknown function (DUF4597)	Coggill P	pcc	Jackhmmer:Q96GX8	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 63 and 76 amino acids in length. There is a conserved TPPTPT sequence motif.	26.50	26.50	27.60	82.30	25.30	18.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.15	0.72	-4.39	4	25	2012-09-03 13:30:01	2012-09-03 14:30:01	1	1	22	0	15	24	0	61.10	81	62.28	NEW	MCVSS.suSp-EAPVLsDKHLDVPsIIITPPTPTGMs.lPRDSp+sVWhDEsGShsDDGElDsE	MCVSSsSSSHDEAPVLsDKHLDVPsIIITPPTPTGMM.LPRDSppTVWLDETGSCPDDGElDPE..	0	1	1	2
+15220	PF15367	CABS1		Calcium-binding and spermatid-specific protein 1	Coggill P	pcc	Jackhmmer:Q96KC9	Family	CABS1 is a family of proteins found in eukaryotes. It is also known as NYD-SP26. It binds calcium and is specifically expressed in the elongate spermatids and then localised into the principal piece of flagella of matured spermatozoa.	27.00	27.00	50.90	50.90	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.29	0.70	-5.60	9	23	2012-09-03 14:10:36	2012-09-03 15:10:36	1	1	20	0	11	26	0	382.60	67	87.66	NEW	MAEDG.PKIYSHPPTESSKTsTEATIFFGADNTIPKSETTITSEGDHITSVNDahhEuDFSTTssNKLTssKE+lKSEDDlEu.hlKSoThhEKEITTLTuTsNShAs-SITENFIPVKIGNISSPVATVSLIDFSTNhAKEDILLsTlDsGDc-Vs.hTSElSGol+-STsslsDTPsLPscpscsDs...sSSsKSsssADtsVQlTDS.lPEAEIsPoTE+NlTTIPDITslTEEKITEIDLIlsEDDPssVsKLTDSDEEKFITVFELTsoAE+DKDNPEDh.LsDEESTDElNVWMER-pssEAEoHsVLLTAVESRYDFlVPsSlAhNlpE-Ss..T..c..EDLsENspsESVTKsTEshS....tsTs..Ds.spcEDs.TTEoGlFKLLKE-PDEFhI	.MAEDGLPKIYSHPPTE.SSKTPTtATIFFGADNsIPKSETTITSEGDHVTSVN-YhLESDFSTTTsN..............KLTssKEKLKSEDDhtochIKSTT.HLpKEIToLTGTsNShs+DSI...TENFhPVKIGNISSPVsTVSLIDFSTsIAKEDILLsTIDoGDtEls.ITSEVSGTLKDSoAulADoPAhPccKDEuDhsNYsSSlKSNVPADEAVQVTDShIPEAEIPPusEcsFTTIPDITALpEEKITEIDLsV.EDDssAVupLTDSDEEKFITVFELTTSAEKDKDN.EDTLLTDEEST-GANlWMER-oANEAETHSVLLTAVESRYDFVVPASlATNL.sE-SST-..EDLSEs-pTEoVsKlTEPFS....uTTSlLDTPsaKEDTSTTETsIFcLLKEEPDEFMI..........	0	1	1	2
+15221	PF15368	BioT2		Spermatogenesis family BioT2	Coggill P	pcc	Jackhmmer:Q96M83	Family	BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis [1,2,3].	27.00	23.80	57.00	23.80	24.70	19.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.08	0.71	-4.49	9	46	2012-09-03 14:16:37	2012-09-03 15:16:37	1	2	17	0	13	36	0	153.80	67	46.74	NEW	MKsuKa.hsoSsKl.ssVPELs.KKGlh.s.shSscsKEK+SuKll+sKlEPMVLRS.PPTGESllRYALPIPSSKT+-llucDEhl++IT++LKMlVSTLE-TYGhs..hpsGEcshsKsEpE-h...sLSVGDDlsSFLhpCSphAuQLEEAVKEEcsILESL..FKWFQtQVNQMEE	...MKPsKHLLToSsK..ssVPtLshKKGLh.N.PlSPchKEKHNAKLl+DKIEPMVLRS.PPTGESIVRYALPIPSSKTKsLlsc-EMItKIhKHLKMVVSTLEETYGtC..spNGEcshlKpEpEEL.........oLSlGDDhsSFLhhCSQFAuQLEEAlKEEpN.....ILESL.....a.KWFQhQVNQMEE............	0	1	1	1
+15222	PF15369	KIAA1328		Uncharacterised protein KIAA1328	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86T90	Family	This function of this protein family remains uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	28.00	28.00	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.40	0.70	-4.62	8	73	2012-09-03 14:28:52	2012-09-03 15:28:52	1	4	37	0	31	57	0	214.80	46	55.11	NEW	DLCPEDKRRIANLIKELARVSEEKEVTEERLKsEQESFEKKIRQLEEQN-LIIKEREALQ...QYRECQELLSLYQKYLSEQQEKLohSLucLuAA+tpEQplSu+KSshpsus.c.....LDGSYLulAtspshhpsp++sKuuspupuupohsshpNs.sh+sphhppPp-shcc.P.Es...RoCssctssh+.tsst.hcp.....h...-.+hpEh.shpPsssocsCuH+putsuspl+-upasophu.ppstophcoCsasphshsS.hptpsh.ts.ETpluKplSE-RRQQLLLQKMELEIEKERLQpLLAQQEsKLLLKQQQL.HQSRLDYN	........................................sRlscEKE...pch+sEppphE..lp.Lcppp.hh.pE+..h............................................tts...pp..osccs..pps..p.....LDGSYLulutst.h...ptt.pss..s.ss.s...hpNp.s.p...h..spcthtc.s.cs...tsss.t.sshc...s..hc..........-hphpEh.phpss.p.psCu.c+hu..ss.spps.pstphs.phstop.coCsasthshsS.hpstsh.ts.Ep..t+p..E-++ppLhhQKhpLEhE+E+LQthLspQEtKLLhppQQL.pQSphpYs..............	0	5	9	15
+15223	PF15370	DUF4598		Domain of unknown function (DUF4598)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N5I9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 159 and 251 amino acids in length.	27.00	27.00	27.60	27.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.51	0.71	-3.78	7	138	2012-09-03 14:34:31	2012-09-03 15:34:31	1	2	125	0	98	135	0	109.00	27	54.16	NEW	sLLSRLSAFLPpMKsAN--LpREItAGR..uKDlpLD-lD-.p-GQ....YIEMNLGLGVLEEKR....ssDssusstp.scupc......s.stpts...pDSslL-+LhGp+csossp.......KPoIpEhs	...........................lLs+lpsFLPphtpAN-cLccchss.us..stchsI..E..sl--..scsp......................hIEM............sluLG.lh-p..pp...............stcs.ppssp.spp.sspc............ts.tppp.p.ttpt...........................................t...........................................................................	0	32	44	69
+15224	PF15371	DUF4599		Domain of unknown function (DUF4599)	Coggill P	pcc	Jackhmmer:A6NFA0	Family	The function of this family of eukaryotic proteins is not known.	27.00	27.00	28.70	28.10	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.12	0.72	-3.92	56	185	2012-09-03 14:35:58	2012-09-03 15:35:58	1	4	23	0	114	144	0	88.00	33	9.50	NEW	tRs+pRp+s...ssh+u....pR..p..spcEsE.cspcLlSlLcS.h.u...........hLspc...s...shRpLLCsDPsCpVCNssssElp.....pLLhtEshp.s.uss.ss.usssu.sus	...........................t+s+pRt+s...ts.+u....pR..pspcEhE.ch.......pcLlSlLpS.h.G...........hspcu...sh+pLLCsDPssclCpsssschp.....phh.tEshp.s.uss.sluPhsusss.......................	0	15	15	15
+15225	PF15372	DUF4600		Domain of unknown function (DUF4600)	Coggill P	pcc	jackhmmer:A6NNP5	Family	\N	27.00	27.00	29.60	29.60	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.74	0.71	-3.93	11	65	2012-09-03 14:38:42	2012-09-03 15:38:42	1	3	40	0	35	65	0	99.30	45	50.06	NEW	cEuNEWKTRYETQhElNcQLE+QIhhL+c+lEph+s.NspD..+hu....SlRs............h-ph..ospuLpphlKpLE+EKptLpsQL+-hEhRL-QEuKAY+Kss-ER+tYlsElspsp.ss.php++Qphs...thpcsscs.scs	.......s-hphpYcs.hEhNppLpcph..hppphpph+u.sspD.ths....sl+s............h-pM..ss..-SLNpLLKQLEcEK+sL-sQlK.hth+LEQEuKAYpKhssER+sYLuEhopsS.s..phs++Qphsth.chpEp...s..............	0	9	11	15
+15226	PF15373	DUF4601		Domain of unknown function (DUF4601)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NA69	Family	This protein family is a domain of unknown function, which is found in eukaryotes. In humans, the gene encoding this protein is found in the position, chromosome 19 open reading frame 45.	27.00	27.00	31.60	27.50	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.46	0.70	-5.62	11	46	2012-09-03 14:42:42	2012-09-03 15:42:42	1	2	32	0	25	42	0	319.10	42	85.36	NEW	LFppDsRWsupE+VSEs+RAF..PPPs..shp..pEpsRERohAhQuSsL+lHADuRstssLSoARusYGWPElPs+A+EpIRGARLlFDRDSlPsGDR-KLRIPsTTaQshFPP+DA.sPQPRAPspHL.GGPNsL+W-YcpQ.-sTSYQ+QFQALPuPPALMCKRASSSVcLGDsKIGYuPhCSEQKpAYpPQsLPPD..RYDKAQAuAHIHpVNIpPGDuLF+DRTTpu-HFYu+EP.EPFVLHHDpTPESHILcGNWsPG.PGSLsTShphFYG.QPsPsTpPPuRHlsH-pLQSHl.sLG-PcLLGpFFQToMuoDYsPs....phs.......p.p+AsNL+LhpSpLPpsouEhDFLToN.QpMlKPHphssASsTEEhLQRCKYSHlEPPLGpQRFFSTQYcDEFPaKYQGPsVL+.hushQESHVPLGTs+phGChtcKlDPpAPQhPhYPCPSQ	..........................................s.....a..................t.......sphph.ts.p.t...o.hp.t..h.t...t.....ttst.hatpDohPsGD+p+lchP.osaptha.sa-h..psts.+sPshHh.uGs.sslphs.hptp......tToYpppFp..uh.usPAh....p.+ch.t..Spl..hGD.phsht..so..pphhts.t..s.t..R.Ys+tpAsu+lp.ss..ltsGDshh..c.p..TThscpFh.spcs.-Phhlc+c.ppstSpIhcGshsPG...suu...ls....T...hphFau.psss.s.......spPsscclspc+Lp..SHV.pLG-scLhtpFFpTohsoDYhss....ph...........p.p+s..sshph..Stl..s..ssp.salThs.pthh.hPH.t..h..t..hoc-hlQ+s+hSHh.sPhst.+aFSTpap-pas.K.Y.uPhs.p..tp.Qcu.lPlGo.t.............................................	0	5	7	11
+15227	PF15374	CCDC71L		Coiled-coil domain-containing protein 71L	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N9Z2	Family	The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.	30.00	30.00	30.40	32.10	27.60	29.80	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.17	0.70	-5.14	18	76	2012-09-03 14:45:56	2012-09-03 15:45:56	1	2	35	0	40	87	0	232.80	33	89.74	NEW	sEEKAVHSWSR..ISoAGpKALEEAL+VFNPMSpDLosTEsQLVAFLQGLR--GFQPTILRSKDVYGYSSCTAssPSQTKhpspssssss..sSsPs+ssppuhthssu+ustlshslssp.uKsustslsK.tsoTNLLLsSLKQopuspupssshuFPsphYPGVYPAMRLSVVLEALVP..LKssssCLpuKh......pphtLulusSslKLhKssu.s..ps..Ks.......hpsKu.pplhp+ust..............GPptsshppSpssKuoG.LsGhhhpsuSphssptspspt......................................................................................+spt.s.sphsh+stpsp.EshG.pKRK+s-EsK-hss+K+s+.hP....s.K.....splspuThsLL+FpsIKVs+....psSDDEVRp+AQ+ILRVNLSPVIRlQPL	.........................t+sVhuhup....ssuppsht-AhhlF.PhSp-h.so-tphhsFlptL+cp.hpPhlLpStDVYGYsSsps....................................................................................................................................................................................................................................................................................................................................t....hh..t............................h.tt.........t..........us..phhph.sI+Vst....p.S.stsRppApplLpVNLpPhlplp.h.............	0	3	5	10
+15228	PF15375	DUF4602		Domain of unknown function (DUF4602)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NDD1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 173 and 294 amino acids in length. This family includes Human C1orf131.	27.00	27.00	27.00	27.00	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.55	0.71	-4.10	42	158	2012-09-03 14:46:48	2012-09-03 15:46:48	1	3	126	0	111	162	0	137.30	22	56.05	NEW	VsFps.p..........p+cpp.........................p.stspspst.t...t..tp...................ptp.tpchslc+.s.......+h-VpcFGhouapt.cp++phctppslpLGAKsP.KpphlNYKhlhpppKppKtcccc.ctphtptsshhptppp......tpppppc+ppcpcsss	.....................................................................................................................................................t.tt.pptpt..t.t........t.................................ptpppchslcK.s.........+hEVccFuhos.h..st.tc++phEpccsltLGAKPs..KpphlNYKhLppphKcpKttccc.ccch..tptss..hhppppp..........ptpcpppp.ppp.....t........................	0	43	58	85
+15229	PF15376	DUF4603		Domain of unknown function (DUF4603)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q92628	Family	This protein family is a domain of unknown function. In particular, this domain lies at the C-terminal end of a protein found in eukaryotes.	27.00	27.00	39.70	38.70	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	1286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.37	0.70	-14.36	0.70	-7.37	11	83	2012-09-03 14:47:49	2012-09-03 15:47:49	1	3	49	0	49	72	0	742.60	54	88.25	NEW	GPlSsSEMSLL+ALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQ..ENDIFLGWEKGuhKKWGKSKKKC.oDLoLEEMKKQAAVQCLRSASDESSGIETLVEELCS+LKDLQSKQc.EK..IpKKhEGS.SPEs-.SPoAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKuKlCSYSSSSSSSTAP.TSTDTSSPKDCNSEuEssKERsspA.s...ssspE+uQ.pRSKpEKEN+hssuss...EEK.sshhKKQsRH+SEGKhRPRSWSSGSSEAGSSSSGNQGEhKsu.hKhVKVRHKsREs.RNKKG.RuGQsRhshKss-KsER+stuG.....sSuSuuuGul+.QLCKRGKRPLKEltRK-uGspEuK-lhsEu+s-KEYKEEPLWYTEPIsEYFVPLS.RKSKLETTYRs+p-ssshs..SEAVE-LSEuV+GLCISNsNlH+TYLAAGTFIDGHFVEMPA.VlsEsh-LsGTShCS.PEDspaLDDlHLSELTHFYEVDIDQSMLDPGAS-shQGESRILNMIRQKSKEcsDFEAECCIVLDGhELQGESAIWoDSsSSlGAEGhFlQ.DLuNLAQFWECCSSSSSsDADGESFGGDSPlRLSPlLDSThhsschLAGNQE..LFSDssEGS.GlNSs.FSVFEVQCSNSVLPFoFEoLNLGsEN.TDSsSosNhLGKTQSRLLIWTKNSAF-ENEHCSNLSTRTCSPWSHSEETRSDNETlNlpaEESoQFsuEDINYVVPRVSusYlDEElLDFLQ--oCQQppcoLGEhPo..LlFpKKSKLESVCGIQLEQKsEsKsaETsps.sssuS.pGDsYSSGVIKDIWTshuDRsSsAsl-s-ch-..-cLFSsDVNsY.CCCLDsEAKhEslQ-.spKAVQRSEYHLWEGQKtshEKRAFlss-LSKVDG.GDYTTPSKPW-lspDKE.sSFILGGVYGELKTFuSDGEWAVVPPucs+GSLLQCAA.......SDVVTIAGTDVFMTPGNSFAPGHR.LW+PhVSFEQuEQs.KuG-sGLNKGFSFIFHEDLLGuCGNFQsEEPGLEYsFSSFDLsNPFSQVLHVECSFEPEGIASFSPuFKPKSILCSDS-sEVFHPRICGl-RTQYRAIRISPRTHFRPISASELSPGGGSESEhESEK-EuSlPlsSQsDVF-DPQADLKPLEEDAE+EGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQE-SuGlLPhscQs.CL-Cshp-olpss.hESScusCKlhpppppEhschCSCcsuCphPshp-s..luust.hpEFPlLNsDlQshstuQpcpsWWpKALaSPLFPuSpC	...............hsss-MS.LpuLGPVQoWLGQELEKCGIDAMIYTRYVLSLLL+DSYDYD..L..p-Q..EpsI.LGhtc.......Gsh++.hs...+u++..Ks...shs..hE-...hKKQAAVQCLpSASD-sS......GIEoLVEELCs+LKDlQ...scQ........c...EK...hp+K.-tu.sP.Eht..S.ss+...DpsEMYY-AFPsLspp.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	8	10	24
+15230	PF15377	DUF4604		Domain of unknown function (DUF4604)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96AT1	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 141 and 174 amino acids in length and contain a conserved LSF sequence motif.	27.00	27.00	28.70	28.10	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.42	0.71	-4.02	68	196	2012-09-03 14:49:01	2012-09-03 15:49:01	1	3	171	0	140	196	0	148.90	26	88.71	NEW	ppsloYsc..sEPsFLp+h+.sphGhppss..................s+cpth......................sscscss.s.-..cp.....D-tPpVVllc.ss.-Lot.-Ehpthhpt...........................ttppppptsstsuclha+ps................pKRpsscthssts.......................t.ttt..............tt.tp+ppp+pp+..tpshLSFs---	..............................tpsloYsc..sEPuFLp+h+.pphGhppss.....................spcp.h........................sscscsss.-.......cc.........D-tPpVVshc.ps..cLot..EEhpthhpp..............................................................tttptppp...ssssuclhh+ps..........................................tKRps..schh...ss.s......................................ttt.t.............ppp.ptp+pppKphK..p..LSFs---.......................................	0	42	66	108
+15231	PF15378	DUF4605		Domain of unknown function (DUF4605)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96D05	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 82 and 137 amino acids in length.	27.00	27.00	27.30	27.00	24.40	26.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.63	0.72	-4.27	13	84	2012-09-03 14:50:09	2012-09-03 15:50:09	1	2	46	0	54	67	0	59.00	54	46.72	NEW	olFuplNcpLlshGFPphphGs+lVEPlsslhhhhlLhhlGlpGLLLVGllhlVhhhs.Qc	...o.Fu-LN+pLlNMGFsphahGp+lVEPVhsIhhhhhLhhLGlpuLhLVullhLV.hhsQp....	0	8	11	25
+15232	PF15379	DUF4606		Domain of unknown function (DUF4606)	Coggill P	pcc	Jackhmmer:Q96LL4	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length.	27.00	27.00	31.90	31.50	22.10	19.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.35	0.72	-3.96	13	38	2012-09-03 14:51:17	2012-09-03 15:51:17	1	1	33	0	26	26	0	100.60	56	38.32	NEW	CsVPcELlNRIahKNhRsslKQsusu+pHlsSQCPsCN+KRAELAQusFLRpKKTLLEShLLpEKIDEHLaTKDhLThIGEAHpuLPRLSDDP+IIWKRLsEKu	...........................CTVPDELlNRIYhKNhRso.KQhusAKQHlSSpCPsCN+KRAELApuAFL+pKKTLLEShLLQEKIDEHLaT+DFLThIGEAHp.s.hPRLSDDPRhIW+RLspK......	0	5	6	9
+15233	PF15380	DUF4607		Domain of unknown function (DUF4607)	Coggill P	pcc	Jackhmmer:Q96LP6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 207 and 359 amino acids in length.	21.00	21.00	95.20	95.10	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.82	0.70	-4.94	4	19	2012-09-03 14:52:14	2012-09-03 15:52:14	1	1	13	0	6	20	0	243.90	63	81.77	NEW	hAhKRLL.sTpQhllPRs.sVSTsSF---SYtEhtspPsPSSEhDEsPhhFTsctEhp+csRtsP+QAWSSshLEQ.hst+PshsHSVNPlHLEAtGhHIpRHsRPpsQPLsssKtsSGSsARPaTAIGLCRRSQTPhA.QSsu.SsoE.E.EERhAAPAGu.AHPD.lQSRLLGAoGssVs+GAVAMAPEMLPKHPHsPccRRPRADoSLHGNLAGAPLPLLAGASTHFPSKRLIKVCSSAPPRPoRtFHTVCSQALSRPVVNAHLH	......huhKRLL.pTCQYIVPRS.oVSTsShDEE..ShtEhpSSPuPSSETDEAPLIFTAcGEsEcRARGsPKQAWsSSFLEQ.hspKP.shs+SVNPlHLEAtGIHIsRHTRPKuQPLSssKpNSGSuARPhTAIGLCRRSQTPsA.QSsusSsoEhE.EERhA.sPAGu.AHPD.lQScLLGASGNPVGRGAVAMA.PEMLPKHPHsPccRRPpADoSLHGN.....LAGAPLPLLAGASTHFPSKRLIKVCSSAPPRPoRRFHTVCSQALSRPVVNAHLH..	1	1	1	1
+15234	PF15381	DUF4608		Domain of unknown function (DUF4608)	Coggill P	pcc	Jackhmmer:Q96MR7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 85 and 157 amino acids in length.	25.00	25.00	26.90	116.20	22.20	16.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.57	0.72	-3.84	3	10	2012-09-03 14:53:25	2012-09-03 15:53:25	1	1	8	0	2	4	0	72.90	90	60.65	NEW	SSAETLRTVSRRSVPSSSMPYLALAHSRVSSLNHAASVDGsuTSHRNVADSFSRTSRSCSRFLKGTAGSAGR-Gs	SSAETLRTVRRRSVPSSSMPYLALAHNRVSSLNHAASVDGWGTSHRNVADSFSRTSRSCSRFLKGTAGSARR-..s..	0	1	1	1
+15235	PF15382	DUF4609		Domain of unknown function (DUF4609)	Coggill P	pcc	Jackhmmer:Q96N06	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 70 and 139 amino acids in length.	27.00	27.00	122.40	122.30	19.60	17.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.32	0.72	-4.27	7	23	2012-09-03 14:54:21	2012-09-03 15:54:21	1	1	18	0	10	23	0	69.40	74	58.25	NEW	EKPDsKtKSSKKKsVIPQIIITRASsETLlShuS.sS-EQRTI+EpADWGPYtRHRNPSTssAYssQs+E	.EKPDVKQKSS+KKsVVPQIIITRASNETLlSsSSoGSDpQRTIREpcDWGPYtRHRNPSTsDAYssHhKE..	0	1	1	2
+15236	PF15383	TMEM237		Transmembrane protein 237	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96Q45	Family	This protein family is found in eukaryotes. The function of this protein is to aid the production of new cilia in ciliogenesis. Mutations in the protein cause a disease, named Joubert syndrome type 14 (JBTS14) and also affect cell signalling using the Wnt pathway[1]. Proteins in this family are typically between 203 and 512 amino acids in length. There are two completely conserved G residues that may be functionally important.	27.00	27.00	27.50	31.90	25.50	26.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.54	0.70	-5.25	22	115	2012-09-03 14:55:22	2012-09-03 15:55:22	1	7	77	0	76	122	0	207.20	32	51.64	NEW	sstpt.sscltscs-Dhhs..........-.t....pp.s.hsssph.SQP............ss+laVE+s..pcFpssc+schh+spp.h........cshh-.csh....aooh-lAlplacuF+hlulasHGFLAGaAlhphlllasLsupphst..............sLLppYphLAhPhpulhYhLLslSoVSAFD.............Rl-lu+sshs...lRshlplsssuLs.hlYFsuLlloLSpphhs-+lshh......s.ssshasssscpp...........llpsWhhlNllhAlLsuLuWlhluhpPspDhs	.....................................................t.................................................s.P.........................splalpts..ttFpthc.......hpt......................p...c.c......hoshclAhsVp+sa+hluh....hsHGhLAGhAlhpllhlasLsspphstl.................................................................sLLppYpslAhPhpshhYhLhsluhlSsFD.........................Rh-hu+hohu...hpth.ls.hcsssls.h....lYhssllLolspp.hs-+ltLh.................ss.N.olh..thtpp.............llpsWhslslshulhshhuWlhluhpPt.Dh....................	0	19	27	53
+15237	PF15384	DUF4610		Domain of unknown function (DUF4610)	Coggill P	pcc	Jackhmmer:Q9BUH6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 164 and 206 amino acids in length. There is a conserved NPG sequence motif.	25.00	25.00	30.50	59.20	22.60	23.10	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.30	0.71	-4.78	6	40	2012-09-03 14:56:59	2012-09-03 15:56:59	1	2	28	0	21	47	0	176.00	56	94.80	NEW	ssLCTLs.sGsspPRaVCYCEspputt..stGlFNltlTsus-lWSTphos-SLuphKu+FGLsuTEDhssRFRsACpQQsVuloLQED..pAsLpLuGsPSsLoF-LSKlPssEAtPRLpALhLpLA-+VpsLEpRLAssEpoAhSPRKSsp.uusp.FhP-.-+QRGGsGsGVR+RhPGESLINPGFKSKKPAoGVDFD-	....................................................sLChls..sGstsP+aVCYCEs-tst..hstusaslhVTDAsELWSTsFoPDSLusLKA+FGLousEDhssRFRuACcQQAVsloLQED..+ASLTL.SGusSuLsFDLSKVPuPEAAsRLQALTLuLA-+VpsLERRLA..AsEcs..A.......sSPRKSsp.uGsQ.LFLPDsD.QRG.GsGsG....VRRRC..P.GESLINPGFKSKKPAuGVDFD-.........	0	5	6	7
+15238	PF15385	SARG		Specifically androgen-regulated gene protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BW04	Family	This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue [1]. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.	27.00	27.00	33.60	27.90	23.30	26.70	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-13.05	0.70	-5.13	31	124	2012-09-03 14:58:22	2012-09-03 15:58:22	1	4	37	0	65	113	0	341.50	32	92.15	NEW	ps.sDpShcaL....otEEK-sLLFhEETIsSL.-s-h-s....slss..Dputpsp................uPp.........s.EEosspp...sEPcclh-hsps.......u.shput..shuLPcshp.hu...pspsh+cs....s.......t.pppth....s.P....pst.s.......s.Pstsssustsss.ch-hl..sPPtt....pPchtp.......psspPhs.upp.........................pcc.susEuhS.pusp+sscss.t..ps.su.sspsu.............................t.pt..sP.sAPK.s++hPsNIslpsSpu...shp.s.t......Nh.pR+spshss.sus.....sps..pcppKuRhpuLcKhGLPpDp.p-suht.......................................................................................ssuptssstshsh.hsppttspus.op....................sss........hsGhp..p.shKSpohchsusGhoshhps-...hssp.p..pp.uptShh-+hsP.sshpssR.RsuSLs...............................Rsth.RP...sloVphS....s+Gss-EpRREAL+KLGLLKE	..................................................................................sDpShcaLotEEK-sLhFhEETIsSL.-t-h-p..h.s..Dps..s...................ss.......t.cts.sp........tspphhp.sps..........s.t.t....tl.p..t.hs.....s..hppt...........................s.....t...................s......chp.h..sPP......p.p..t..............t....s...upp.........................pcp.htspshs..s.ptt..p.......t...ss...tph...............................t...ss.ssPK..p+hPsNI.lpsstu...shp.p.t......ph.ptpsps..t..s.................................p.p..t.tp.s..tp.............................................................................................s.........................................................suhp......p.shKSts..h.shGho.hhpst.................sh.t...h.s.sh.ps.R.RssSLs................................................ts.h.RP...sloVphu....s+GsspEtRREAL+KLGLL+E...................................................................................	0	3	8	27
+15239	PF15386	Tantalus	PRR14;	Drosophila Tantalus-like	Iyer LM, Aravind L, Eberhardt RY, Coggill P, Hetherington K	pcc	Manual	Family	An alpha+beta fold domain found in metazoan proteins such as   Drosophila Tantalus [1]. Drosophila Tantalus binds the chromatin protein Additional sex combs (Asx) and also binds DNA in vitro [2].	32.80	32.80	32.80	32.80	23.20	20.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.25	0.72	-4.21	13	121	2012-10-09 15:10:48	2012-09-03 16:02:35	1	2	64	0	68	111	0	61.80	60	8.38	NEW	sslTPh.GLP+stR.l...pKKEhSL.EEIYTNKNYKsPsst+sLETIFEE..Pcp................+sGslhhh.s+Kh	.............NLTPM.GLPRP+R.L......pKKEFSL.EEIYTN.KNYKSPsspRsLETIFEE..P+E...................RNGoLI.hSppKh...............	0	9	12	35
+15240	PF15387	DUF4611		Domain of unknown function (DUF4611)	Coggill P	pcc	Jackhmmer:Q9BXV9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 71 and 100 amino acids in length. There is a conserved AKR sequence motif.	27.50	27.50	27.50	57.60	24.40	27.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.14	0.72	-3.84	9	26	2012-09-03 15:05:01	2012-09-03 16:05:01	1	1	20	0	11	34	0	90.10	53	94.44	NEW	LlGEaVspDGppQ+lRlsCEusu-usshQuLLSGlAQM+EhVoELhusLVppEtpstlsuss-Eul-.GsDEDDuED.EsNhcs+T.....sSsGPsAKR.KP	.LLGEYVGp-GpsQ+LRVsCEAPGDuDPFQGLLSGVAQM+ELVoELFusLVppEsQppVAAuP-EuLD.G-DEDDuED.EsNhss+T.....s.sGPsAKR.Ks...........................	0	1	2	2
+15241	PF15388	FAM117		Protein Family FAM117	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9C073	Family	This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.	27.00	27.00	27.60	35.90	22.30	26.10	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.52	0.70	-5.20	19	194	2012-09-03 15:06:59	2012-09-03 16:06:59	1	3	59	0	110	184	0	263.60	45	73.36	NEW	lRRTuSLDsIsusYLpGpWP+-.scs..hssp.hpDKuTQTPsuWsEpstp+p...........t....tH+RSASWGSs-pL......+E.........luKL+QQ..........LQ.Ro+p..us.........tspc+cppush.Gspus.....hstsp.........t....shss...sshtphssphRpSlEGLNQELEplal+......ppsc-phht.......l-lPDGHRAPlPs.t..t..................susspo.sspss.........u....Ssssuss.s.........s...ps.ssssp.tpsh...hs..........................................tsssP....h.thuoSP+PN+ohhFpREPPEGCE+V+l.hpE.ts.sp.spth...sCPDcNKVsFpP...sGSAFCPV.ol.hpPLh....Pos-hhh.ps.	.................................................................lRRT.SLDsl.husYL.GpWPR-..sph..hssh.hpDKAT...QT.psWsEptt-+p..............................sHpRSASWGSsDpl......KE..........IuKLRQQ..........LQ.RoKp..sSR.........pt+-K-RpSPhp.....GsHss..........hspsp..............ssPhs.h..s.s..hs..tp.ssphtsSlEGlNpElEtlhlK......tptcEplh...........-lPDG+..RAPhP.....p....................SusopolsopoPs...........tpsSs......ssp.pssss........h.....tstptSPpst.cshh..p.t.............................h-sGssSP.......l.taAoSP+PNpSYhFKREPPEGCE+V+V.FEE..h..sst..hth....h.CPDKNKV..sF.P...oGSAFC.V.pl.htPLh.....Ps.shhh...st..................................................	0	18	29	58
+15242	PF15389	DUF4612		Domain of unknown function (DUF4612)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H246	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 109 and 323 amino acids in length.	27.00	27.00	31.70	28.90	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.78	0.71	-3.48	10	88	2012-09-03 15:07:59	2012-09-03 16:07:59	1	3	69	0	58	69	0	104.90	46	53.32	NEW	GCsSAKpVusV.s--............-.spuKsauNGDshsD...EY+hKsVEcVKYh+s.....EEp+hsupsppsh........cppsptt+s+spscsuutsst.h...............slHlSESQQEFFRMLDEKIEKGRDYCS..tEE	.................................................................................................GCspuKphstl.ppc............cst+t+satsuDshsD...Eh+hcssEcsp..ps................-Ep+hsupspcsh.....ccpsssph+hpsstchsu.spt.h..............tshcI.ScSQQ-FFRMLDEKIEK.G+D..YsS-pE..c.....................	0	11	15	34
+15243	PF15390	DUF4613		Domain of unknown function (DUF4613)	Coggill P	pcc	Jackhmmer:Q9H6R7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 625 and 725 amino acids in length.	25.30	25.30	134.10	25.30	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	671	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-13.21	0.70	-6.35	23	69	2012-09-03 15:11:50	2012-09-03 16:11:50	1	3	41	0	44	65	0	614.70	48	94.99	NEW	ELGKGKLLRTGLNALaQAlHPlHGlAWTDG+QVVLTsLpLpsGEsKFGDSpVIGQFEHVpGLoWuPhssuDs....PuLLAVQHKKHVTVWQLs.SssEpuKhLhSQTCEIpEshPlLPQGCVWHPKpslLsVLTu+DsSVhhsVHsDuoRVKADI.pspGhIHCACWTc.DGpRLVVAlGS..uLHSYIWDssQK.TLptCSFCPVFDVsu..hlCuIpATVDSQVAVATELPLDKICGLNAutsFDlPssuE...sss..hto.s.lhs.-.hshD..ptussSEss.St.sSlu....SS....osPLDLTHIhhs+p+S-sSuLlpLR+KDaLTGoGQDSSHLlLVTF-+.cVTsTRKVoIPGILVPDlIAFssKuQlVAVASNTCNlILlYSlhs.SshPNIQQIQLEssERPKGlCFLTDKLLLILVGKQK.sTDsAFLPSScSDpYhIRLhl+Elhh---sSsosstsQsshss......hsshLspus++KhhEsLSs.-hp.ps.+sLLLsusss...pSspstRpL.IcEI......+SP.........soSss..s.....uS....l..................s...L-...scPsspssol......................s....psS......usP..s.....tssp...Es............................ss..lPp..p...psL...ppEKEsppLo+pLEtLSpshs-lQpsLSELpDhLpNGK..Ks..sssYPhSpDPPYVHIsYQKshssssls.EKRuVLLCcGKLRLSsVQQhFGLSLVEMhHu.SpWILLsADoEGFIPLTFoAsQEllI	.................................ELGKuKLLRTGLNALaQAlHPlHGlAWTDGpQVlLTsL.hpsGE.sKFGDSpV...IGQFEHVpGLtWuP.sssDo....PsLLAVQHKKHVTVWQLs.SssEp.sKhLhS.QTCEIp-shPlLPQGCVWHPKpslLsVLTtpDsSVh.sV+sDsoRVKADI.pspGhIHCACWTp.DGpRLVVAlGS..uLHSYIWDssQK.oLptC..SFCPVFDVsu..alCuIpATl.-uQVAlATELPLDKICGLNAu.sF-lPssuc...sss.....s.s.lhs.E..shD..ctussu-ps.u...Slu....SS...ssPLDLTHlhhspp+S-sssLlpLR+KDhLTGoGQDSSHLlLVTF-+.tVTpTRKVoIPGILVPDllAFs.+uplVAVASNTCNhlLlYSlhs....SshPNIQQIpLEpsERPKGlCFLTDKlLLILVGKQK..sD.ssFLPSSpSDpYhl+Lhl+Elhh-c-sososstsppsh..ps......hss.lshssc+KhhEsLus.-hp.ps..+sLLlsssss...QSspstRpL.IcEl..+Ss..........ss.sssSh..................s.Ls...scPsspssol...............................sp.o......sss.s..tsph...ps...............................sphsp..p...psh...tpE+phtpLo+plEhLstshs-lQpsLSELp-hhpNG+..+s..sssYP.Sp-sPaVplshQKs.h..sssh..E+RsVLLCcGKL+LsslQphFsLollEMhas.s.WIlLsADs-GFlPLpFpupQElhl...................................	0	7	9	21
+15244	PF15391	DUF4614		Domain of unknown function (DUF4614)	Coggill P	pcc	Jackhmmer:Q9H6X5	Family	This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a conserved EALT sequence motif.	25.00	25.00	26.60	26.60	19.20	18.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.30	0.71	-4.51	21	53	2012-09-03 15:12:47	2012-09-03 16:12:47	1	2	44	0	35	45	0	166.20	47	32.84	NEW	psossssYS.-DFEpSsp.spsspss..spSpposspohs..opS-tS...ushposhs........tshps...pcppsps....spclhlK.EsAVQT.....csshsh.Wsp...ssuhAslGPslGuuYVDPsPIAoHVlSsDAlEALTAYSPAslALsDMLKQQLsLTQQFlEsSR+LHtSLlpSL-t-saHYpTLEETKEYIRcHRss	..................................s.s.sssYS-DFEpSsp..psopsp..spScpS.s+Tls..shS-.S.........uShposhs..................pshps...p+cpscp....ssRlhVK.-sAVQT.....-PuFsYpWsc...suuhAshGPuLGu.uYVDPsPIAsHVlSADAIE..ALTAYSPAslALpDhLKQQLsLTQQFlpsSR+LHtSLLpSL-t-sFHYHTLEEsKEYIRpHRP.s....	0	9	11	18
+15245	PF15392	Joubert		Joubert syndrome-associated	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H799	Family	This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis[1].	27.00	27.00	30.50	30.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.12	0.70	-5.21	12	56	2012-09-03 15:16:48	2012-09-03 16:16:48	1	1	35	0	30	46	0	293.90	54	20.35	NEW	PLQMTGLTDIADII-DLITKcGVSS-ELGLTEpQA+sISRIQ+oSGR+PQRT-cERREIQlWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRSsPFYMTSREIRhRQKMKHEKDRLLLS-HYSRRISQAYSLMNELLSESsQLPssAQKPLPs+PpTsphsRpQ+ssSPRRENpHGHNFPlNRPGKsRaIS.KsSahpKG+PhspspGSsh.................................+GSssPspShQps+s+tuAGLsP.ocQVClEYEREETVVSPWhlPS-I+cILH-sHuSLLQDlSPs.EEEPEsP.....htluGhDSlSESTGSILSKLDWsAIEDMVAuVEDKuLSVHWA	................................................PLQMTGLTDIADII-DLIsKcGVSS-ELGLTE.QA....pshSR..I.Q+sS.G.R..+s..Q...R.T-KERREIpsWMKRKRKERMAcYLspLAEKRuQEHcPFC.PRss.P..hY...MTSREIRh+QKMKcEKD.RLLLS-HYScRISQAYuLMNELLSESVQLPsss.pK..PLPs+s.ps.sp.sppQ+.ssSPRt.ENpaGHsh.lspsuKs+ahS.+PSahpKtcshs..spGss..t............................................................cuSssPs.p.p.h+pptsstlsP.sppsC..lEhERE-pVVSPWtlPs-I+pIL+cspsSLLQDhS...ss.EEc.c.s.......hsGhDSlSESTGSILSKLDWsAlEDMVAuVEDpt..s................................................................................	0	4	6	14
+15246	PF15393	DUF4615		Domain of unknown function (DUF4615)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H7E9	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 161 and 229 amino acids in length. There is a single completely conserved residue F that may be functionally important.	27.00	27.00	28.80	28.80	26.40	25.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.94	0.71	-3.89	33	85	2012-09-03 15:17:45	2012-09-03 16:17:45	1	3	70	0	55	85	0	127.30	38	57.03	NEW	cQhcpELsWClpQLEhuL...pstK...opKQtc...-sh+sl+sL+SspsPLlKKRQlM+sthGDYRsKMppEc+Khh+shpshtho.upsps....s+Ku.Fh++uthh..................................sotc.s.phsa.hspp..................................................................pF+FNF	....QhppELsWCVcQLElGLcppKs...o.KQtEpuhpsI+oL+Sp+sPLs+KRQlM+shFGD....YRupMctEppchh+shcsstho.upsps......s+K...h.++sthh.................................pst.t...phphshshspp....................................................................................pF+FNF..............................................	0	20	25	39
+15247	PF15394	DUF4616		Domain of unknown function (DUF4616)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H972	Family	This protein family is a domain of unknown function found at the C-terminal domain of the proteins. This protein family is found in eukaryotes. Proteins in this family are typically between 166 and 538 amino acids in length.	27.00	27.00	27.50	27.50	23.30	26.60	hmmbuild  -o /dev/null HMM SEED	537	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.88	0.70	-5.49	7	55	2012-09-03 15:20:01	2012-09-03 16:20:01	1	2	30	0	25	44	0	360.90	66	96.47	NEW	SFSATILFSPPsG.uEA+CCCCuCKSEssuusous.sGs.P...ssTPITVTGcGLAVQSoEQLLHlIYQRV-KAVGLAEAALuLA+ANNELLK+LQEEVG-LRptpssp.--ssputtpssPscpss.hctSsGcA.pshs..u.EEEs-ulGoGVQVVIEELRQLGAAuu.ssGsLG.FsssQcchchPGCsLAu...sEuuPLLNPh.....DDYluoEGslQRVLsPuaAKQLSPuoQlAhppusu-su.EshschssspPcshLuusAsL....DuAL-..-ssPGuo.......GElphSLG.......assoPsRsRGoGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSESIKSSWNISVVKFLLEKLKQELVoSsHNYTDKELKGACVAYFLTKRREYRNS...LNPFKuLKEKEEKKLRSRRYR.LFANRSuIhRpFuPEDQ+LWcsVTEELMSDEEDSLsEPGVWVARPPRFRAQcLTcLCY+LDANSKHGTKANRVYGPPSDRLPSAEAQLLPPcLYNPsFQp-.s-uGspsuPsSsshspsHKohCPDLNSFIEIKVEKDE	......................................SFSATILFSPPuG.SEA+CCCCACKSEssuussGSpGGs.PP...suTPITVTGHGLAVQSSEQLLHlIYQRV-KAVGLAEAALuLA+ANNpLLKpLQEEhG-LRptpss..tct...s.ttt.P....t..c.u.Gcs.p.......................................h.assspp.hRhPGCsLsu...s-usPlLsPh.s...DDYVASEGulQRVLVPAYAKQLSPATQLAIQRAouEousEsGsKLPssRPEDhLsusAsL....DuALE..EusPGus.......GELphSLG.......hssSPsRsRGoGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSE...SIKSSWNISVVKFLLEKLKQELsoSPHNYTDKELKGACVAYFLTKRREYRNS...L..NPFKGLKEKEEKKLRSRRYR.LFuNRSpl.hchhusE-QphWpsVTEELMSDEE.DShsE.PGVWVs+sPpaRu......LTpLsh+lDAts.cpG.sKtpRh.G....S-RLPSsEsQhhP.cLaN.pap....tt...............tss.......+cs.s...sSFlplKVEcD...............................................	0	6	7	11
+15248	PF15395	DUF4617		Domain of unknown function (DUF4617)	Coggill P	pcc	Jackhmmer:Q9HCM1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.	27.00	27.00	48.00	48.00	15.90	15.40	hmmbuild  -o /dev/null HMM SEED	1068	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.01	0.70	-14.29	0.70	-6.51	14	45	2012-09-03 15:22:00	2012-09-03 16:22:00	1	2	30	0	25	50	0	865.30	45	67.36	NEW	SMELLATCLSLWKKQPSEssE........EKQsN....pSppNpT..ulGlS+Psc.lss+uspSssGN...SQsKhl..s.ppThLSsllQNaESSusslsKGTELQIAVVSPLILS-l+TLS.hKslsPpslPEssYPVIKEGSlCSLQsQ.hsENs.lsA.sLKssl....spPVuSossSsKl.s.LhQ....KEKQ..scsopuss-sssssspGpp.t....p....sshuspQss.co+...........................................cSslVsuDhLQI-sICSLVEGDsSYNSQIAcIFNSsPhp+VEPQKsShPsppslSstpQcEQl-ps...TEs+DhuhQc-ch.lpsTDlSpc.ls-.scs...P.......tc.u..............Stphlcsssuhl.EEuslE+..............hspc...sssslsSs..AuhpQDspspEsDssu...Nhsu.ps.PstsEl.s-.ppslhYL+DQLSELLKEFPYGIEulN..s....+csSVupphspplsc-QTssKps..sDSK-...ssDQIpITlLsS-QhKELFPEpcppss.......csD+lsEsQp.EKsls.....EsusQCDsQss.ppsEopDSs.hsSEKDcl+CC.ALGWLSMlYEGVPpCpCsSlcp.sSpE-Ksc-Qsush.-oNSsKQGEpsScsDlslhc...sss.lsss...PKss....ss...cs+hschcp..c...sh...........................KDtopT+...csoph+sEQ-...ss..QhpS.....KsD.Kh................-shQspK+p.pLpaHEVsFpousK.pt...c.hSQEu......Lp+KhhsQsspPlKsKsshhss..K..D......hh+cssSlhQolSsEKhKlKhpu....hp....pt....EKRKlDpsphh-..ElKKKKp-KQEQN+NsG.ss....hKLssplspsNERA.lpEp.s.....luss.....cSSD.K...sSSsKhp+VlospEY.LQRpKcK-shu.ppsuK+hpl....csVsscSpah+sS..Khsspl.tSssKss-+..psSuhpTsKEshNshss+uKsLKhH+..SE..pSKoaslSpNsKGpsDGKQsDKhhh-Koh.DK.lsplsNEhp.s.hs.QsK-QRKpYLNRVAFKCTERESICLTKL-sSP+K..Lp..K-..K+..p......-sKscs...lssK-socKssMLEFKLCPDlLlKNTsosE-ppshpspPcKEQAsVQVSGIKSTKEDWLKClss+.K+M.EusQE.....D.s.l..sS+Lu+RShSADGhEsLQNPVKDSKsMFQTYKKMYLEKRSR	...............................SMElLATCLuLWKKQPS-ssc........-Kp.s....p.ppspT..ssuhSpPsp.hp.csshSshGN...Spschs.s..ppTsLshlsp....saESouhslsKGoELQIAVVSPLlLS-l+ols.sKslsPt.s.lsEslYPVIKEGSVCSLQsQ.hsEN..ssA.uLKssl....stsVsuossuschhs..hp....KEcp..scsspsss-ssss.spspp......p....sshsspQ.s....ps+...........................................sossVuuD.hLQIssICSLVEGDsSYNSQIAcIFsS.PhphlEspKsShPsppshus.p.ccQl-ph...sEscDhshppsp..lpsTDlspc.ls-tsc....P........c.u..............o.p.lcsstshh.Ecssh-+..............hscc...sssssCS...uuhppD..spEhDsss...........shss.pc.PstsEl....s-.ptslhYL+DQLSELLKEFPYGIEsls..s.......+csSVsQQhs.phsc-p.TssKss..sDSK-...ssDQIpITlLsS-QhKElFPEpcpps.........sDcLtcspp...-csls.....-s.s.ss...phstttc..s.Dsh..so-KD-ltCCALGWLSMlYEGVPpCpCsuhpp.sSppcKtcpQsu...cssSscpsE.psucpslshhp....ps.lsss....Pchs.....st...cschschpp..p...sh...........................+phspp+...cps..psEpc...ssph.S.....psc.p.................ss.pppKtt..lph+ElpFpspsK.hh......SQEs.......ppKhhsps.tPl...KsKsth...ss..p..D.......hh+psShsQolSsEKhKLKhtu....hp.h....pKRKlDpsphhD..ElKKKKa-KQEQppssG.so....hKLssplopsNERAhlpEK.tloss.....cSscsK.....sSSsKhs+llTspEY.LQRQKcKEshu.spsSKchpl.....csl.scSpah+sS......Khsspl.tSsGKssE+..psouspTsKEShsshosHGKslKhH+.....Sc.....-S+oasl.+NsKtpssGKQsDKhah-Ko.h.DK..sphsN-hphsphs.Qs...K-Q+K.YLNRVAFKCTE+ESICLTKL-sSP+K..Lp..+-+c..p....-sK.ps...hss+css-KssMLEFKLCPDhLl.KNosos--ppchpstPcKEQAsVQ.VoGIKSTKEDWLKtlspcp+h.c.ssQch...D.sl..sS+ls+RohSADshEhLQNPlKDS+tMFQTYKpMYhEKRSR................	0	1	1	5
+15249	PF15396	FAM60A		Protein Family FAM60A	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NP50	Family	This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression [1]. Proteins in this family are typically between 179 and 324 amino acids in length.	27.00	27.00	58.70	45.90	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.78	0.70	-4.59	17	107	2012-09-03 15:23:46	2012-09-03 16:23:46	1	2	64	0	60	90	0	190.90	61	71.84	NEW	FuFHKPKlYRSssGCCIC+AKSSSSRFTDS+KYEc-FhtCFtLpE..pRsG-ICNACVLLVKRWKKLPsGScRNWpH.VVDAR.AGPGhKshspthpK.+pht....................hcp+ph..+http++pp.............ss...shsp.........spssSpspSPs.SspS--sspt...................................c.............tptpsp.sl.ss..FlD.oYWKRpclCCGhIF+G..aGEl..llDPcLhKPCssspc	..........FGFHKPKhYRSh-GCCICRAKSSSSRFTDS++YEK-FppCFGLpE..sRoG-ICNACVLLVKRWKKLPsGSKKNW.NHVVDAR..AGPuhK.hsh+PKKhKshs.........................tp....thppp.hp+lpKchKpp..................................sSD......ApSo..........TSSsSPsQSPshSNpSDDuu-s.........................................................Eh............tstpscssl.hS..FLDhoY..WKRp+lCCGIlaKG.paGEV..lIDs+LaKPCCsp+.p................................................................................................................................................................................	0	14	17	36
+15250	PF15397	DUF4618		Domain of unknown function (DUF4618)	Coggill P	pcc	Jackhmmer:Q9NUD7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.	27.00	27.00	27.00	30.80	26.20	25.80	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.67	0.70	-5.05	17	62	2012-09-03 15:26:35	2012-09-03 16:26:35	1	2	38	0	31	53	0	217.00	45	74.36	NEW	l+sR+soL....pELppHcshLschNt-LhcpIQDhEcoTshpVRphLpQQ-lhsollslLEauNc+cLpphKsELQEWcEKpcs+hspLcpQlcpLcu+IcKspEElsFLSTYMDHEYPVKuVQIAsLhRQlQplKDsQQ-ELD-LsEhpctVLtolus+hppKccplLpulshKs.pPhppsLlp+s.hcsQshhKphspaRchIcphcE-lPhL+AEVcpLpsphp.csRElIFtDl.LLR+PKCTPDMDVlLNIPsEEhLP	..............l+st+suLpELps+csaLsKhNp-LlcsIp-hEsSTsLpVRtlLQQQ-hhsollDILEYsN+K+LQph+uELQEWEEKccsKhshLpQQs-QLsu+IcKspEEVsFLSTYMD.HEYslKuVQIusLhRQLQplKDsQQDELD-LsEMR+pVLpoLSs+IQcKc++lLpolVscsppshpp.sLlphh.hcspthh+ph.ta+c.htthpp.h..L.tplptht.p...p.pp.ha.ph.hhphsKCpsp.tl.lpIs.pp....................	0	9	10	15
+15251	PF15398	DUF4619		Domain of unknown function (DUF4619)	Coggill P	pcc	Jackhmmer:Q9NVL8	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 299 amino acids in length.	27.00	27.00	33.60	33.40	25.60	25.00	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.00	0.70	-5.00	10	52	2012-09-03 15:31:30	2012-09-03 16:31:30	1	2	30	0	27	46	0	211.30	53	96.47	NEW	MGLuaSKuHPRVTKVAPLQsKEtETPsAGslDFshsQNLEE+S.aohARLQDpsKuLEGQLPPLREThYGRYSo...ssRsMYFDIPLEpGETSIIKRHPPRRhQKLEPlDLPQVlTScRLLSQpEAc.ssp+AK..QELEK+MQospYoSGKRQYLHKMQMLEMNRKRQEAQhELKKoLH+EARINKQ+.R-HKAKKlLpolPRNDDt.DllThLP-c...sLNRsPGNupNuEFL.pHQstNsYsPRKsGKhEsWlpEQEApGQLhWDSSSSDSDEhG+-EKK...PRALVRTRTERIPLFDEFFDQE	..................................MGLu+SKsH.RVhKVAPLQs+E.Eossss.ltFshppsLEEco.h.hsRLQ-pp+shEGQLPPLpEshhGRh.s...ssRsh.FDIPL.-p.tETSIIK+HPPpRhQ+LEPh.shPpshTutph.spppst.thp+t+....hEK+hQs.hasstpRQaL+KMphLEh.p++QE.....sQhE.....L.K+sLpt-s+lsppp.c-cpucKhhpshs+...sssh....chhshlPsE...hlsc.ssGs..stth..t.p......s.p.s.ht.h.hpp.hptph.h-sSSosS-t.tc.p++.....sLVRT+Tp+IshaDpFhD...............................	0	4	4	7
+15252	PF15399	DUF4620		Domain of unknown function (DUF4620)	Coggill P	pcc	Jackhmmer:Q9P2W6	Family	\N	27.00	27.00	149.60	51.40	25.40	19.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.70	0.71	-3.94	2	9	2012-09-03 15:33:08	2012-09-03 16:33:08	1	2	6	0	1	5	0	98.40	84	76.38	NEW	VPRWPHLS.QSGlcsPshWTtoPG.PSRDQpAPGs.MPPsAAQPSshG.LVPPATA.E.lDcPA.HWLACsCCLuLPuQLPLAIhLGhsL.LcuuP.sGKLCP+ARRWQPLPS	.VPRWPHLSSQSGVcPPDRWTGTPGWPSRDQEAPGShMPPAAAQPSAHGALVPPATAHEPVDHPALHWLACCCCLSLPGQLPLAIRLGWDLsLEAGPSSGKLCPRARRWQPLPS....	0	1	1	1
+15253	PF15400	TEX33		Testis-expressed sequence 33 protein family	Coggill P	pcc	Jackhmmer:O43247	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 147 and 280 amino acids in length. There are two conserved sequence motifs: NIRH and SYT. The function is not known.	27.00	27.00	46.70	45.70	26.10	19.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.60	0.71	-3.78	7	37	2012-09-03 15:36:24	2012-09-03 16:36:24	1	1	29	0	23	35	0	134.30	63	56.81	NEW	SlIPsNIRHKFGSplV-pLlSEEQstp....slschhEtppt.souhPs.hTcs.scl.oohhssYaDLGhshRssLh..GsspETKSLMpuSYTsEVhE+uVRDlEHWH.GRKTDDLGRWHcKNAhshNLQKALEE+huEpsKs+us	...........ShIPsNIRHKFGSphVDpLVSEEQAp+....AIsEshEGQKR...sSuWPS.RTQoPhcl.oSlFSDYYDLGYNMRSNLF....pGuPp.ETKSLMKASYTPEVIEKSVRD..lEHWH.GRKTDDLGRWHpKNAMNhNLQKALEEKYGE+SKS+u...	0	3	4	6
+15254	PF15401	TAA-Trp-ring		Tryptophan-ring motif of head of Trimeric autotransporter adhesin	Coggill P	pcc	Jackhmmer:Q48152	Domain	TAA-head_Trp-ring is the tryptophan-ring motif of some Gram-negative Enterobacteriaceae. The Trp-ring folds into a beta-meander type on the top of the head domain of its trimeric autotransporter adhesin proteins. In conjunction with the GIN domain it is thought to be the region of the head that adheres to fibronectin.	18.60	17.30	18.60	17.30	18.50	17.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.38	0.72	-3.75	23	175	2012-09-05 12:42:40	2012-09-05 13:42:40	1	29	47	1	31	163	2	64.50	44	11.54	NEW	VssspKsNGKtsc.....VKlGsKh.hhpcc-hclhTGKs.................p.ss.sssssssssssspGsGlVTupsVh-..Al	..............hpsKsNG+pTp.....VKlGAKT...uhhp.cKDucl......hTGKsh....................................................s..sss..ssTspGpGLVTAppVl-Al................................	1	1	1	31
+15255	PF15402	Spc7_N		N-terminus of kinetochore NMS complex subunit Spc7	Coggill P	pcc	Jackhmmer:O59757	Domain	\N	27.00	27.00	27.60	27.60	24.60	26.40	hmmbuild  -o /dev/null HMM SEED	927	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.08	0.70	-13.83	0.70	-6.54	19	122	2012-09-06 11:41:45	2012-09-06 12:41:45	1	10	72	0	106	126	0	496.30	28	58.18	NEW	hDKENsTsDluusp..ts.....hsup-KKSRSKSLGPGGLD.ALpsuNGNRRKSsss...hPLKSILKPTlPVSPlpsIPoF-ETR++oPs.........t.t...ptptt.hIshsssstsshsus-p.sNPFDsFsssu..p.......stt-.p.AAAREREE+ER+E+E+c...sILE+R-ARRKSM...................ANRRVSFAPEATLHTWNVVEls-DSToSSuu.NSTRRASSLs.ts......ppsststp.sps.s....pt.t-sshu.SPsp..cLpphppp..pu..s...ss...pphuSSPaSGuSssus-.tulps.t............-.sssSosss.DupuTsMSh--hTspSsuosts.s..tsSosSSu+L-EuLRpAApc.AGTpuID.D-s.s-hSMEhsspEIsGAFpPWlKKu.pppsh-hE.........................DlouchDQENlsP...sstshp.ppsssppsss-..pts.................p.....DhSMDlTpAlGGIlsptpsppp.....shspRpS.u...............t.oshs-QTMEFTsVVGGItpstSstputsssps.ttDE-MTMEFTSslGGVLspshspssspptptt.s......t.........ppssstpss.-MEMTuAVGGILsshpEptp..p..........DpThGM-hT.sAlGtILssthsspsc..ppthhthps-tst.p.sSSPFQtslh.SPs+.ssss....+hsslsSEsGSPoluSl+s+psR.pS.sppsusosssp.os.psSPh+.sshpss............pptsspsspssTPs+TPPSp.phshRuuSP+Klhps-hptsuop......ttssspc......sLFppss.TGpoTPtFVLpPp.....pRRSSGlGID+-GLGSPRVAtlLDRRRSIGE-AtcFlPpp.....ppuVRF-DPhcLpEElD+ERp-EEp+Esu+..lpt.sst...-+DsThNL+-MISSLT...PKKNKL+GRKSLHVGAA+GLLGKRPsELDpD----ssps...sKRLKG.+p.uSPVKsI+LPAPPSKsETs	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................-hsM-hTpshG.tI..h....................................................................p.sh-h...h..tu.........................................................................................................................hc.p..........................................................t...hchp..s.ttlh..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	21	52	87
+15256	PF15403	HiaBD2		HiaBD2_N domain of Trimeric autotransporter adhesin (GIN)	Coggill P	pcc	Jackhmmer:Q48152	Motif	HiaBD2_N may represent the GIN domain of the Head region of TAAs - trimeric autotransporter adhesins. Not all TAAs carry this domain; however, in those that do, the GIN in combination with the Trp-ring domain is necessary for adhesion to fibronectin in the host cell.	25.00	25.00	30.40	30.40	18.80	17.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.35	0.72	-3.82	19	46	2012-09-06 14:40:45	2012-09-06 15:40:45	1	14	15	3	0	47	0	53.10	45	7.47	NEW	TNVsSGL+sYGDTs...hsssssussshs+ps-..sAapGLlNLsEKuu.....s.ps...shVuD	.TNVsSGLKsYGDsN...FsshssSsssls+psD..sAYcGLlNLsEKuu.....sKp..hVAD..........	0	0	0	0
+15257	PF15404	PH_4		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:Q03868	Domain	This Pleckstrin homology domain is found in some fungal species.	27.00	27.00	30.50	35.60	22.80	19.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.26	0.71	-4.76	32	91	2012-10-04 00:02:25	2012-09-10 15:36:12	1	3	89	0	65	98	0	169.50	38	15.94	NEW	hsGhLYpKs++HosFpchhVlLssGhLllFpshhRs.hoGhthp...plcap+hhslsLp-CYlYSGhlTc.DLLppspsaDs...........hsPGp+ulPRlY..sDGWpSs---sspsFslWasp++shhcppts.tp.........................................t..tpstsph+hVspLGssG+S.hVFhARSRtERDhWVhuItsEl	.......hSGhLYpKs++HusFpch.VlLssGhLllFpshhRp.hoGhths...psaap+hhslsLpDCYlYSGhl..Tp.DLLhpspohDs...........spPup+ulPRlY..sDGWpSsD--sspsFslWasp++slhpsppp.tp............................................tpsppph+plspLG.ls.G+S.hVFpARSRtERDhWVhuItsEI..........	0	21	37	56
+15258	PF15405	PH_5		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:Q9Y7U6	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.87	0.71	-4.22	42	284	2012-10-04 00:02:25	2012-09-10 15:41:14	1	12	152	1	212	344	0	136.40	27	11.08	NEW	llaKG.LKK+sssptps....DlpsYLFDHALLhlKhKtlsKtEpaKVY+RPIPLELLhls..........h--hsst.t......pps...........sshlsppssssst.s......pt..pssasITFpaLG+pGYp.lTLYAushsuRppWlEpI-pp.Q	.................hlhputLp+tsspp...s...-l.psaLFD+h...LlLs.+..........h...+s......s......s......K...p...c...p..ac..Va+.......cPIPlcLLhlp.....................................shp-s.sthuh..........................s...............................sshhs.stssssst................tps...p.haPlshp+LG+psh........hTLYAssttsRpcWh-pIppt....................................................	0	62	116	179
+15259	PF15406	PH_6		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:O94356	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.20	30.00	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-4.02	13	72	2012-10-04 00:02:25	2012-09-10 16:46:12	1	1	72	0	58	96	1	108.00	51	19.22	NEW	NFlYoKcFFWFGo.-A...VE..sKsLSuahcu.....-h..tss...AHHssAWAocTGKGLLFFuc.tsDKA.uPsGlIpLADASEPssDGssKFHFTu.KGHKHTFKAuosAERDNWVuQLKsK	............................hhFoK+FFaFus.-A....VE..sKpLosYhps.....EK.....ps.AHsssAWASQTGKGLLFauK.+spDKu.sPsGlINLAD..s..o..-lsp-G.usc...FpF...ph.pGpKHoFpAussuERDsWluslcsK...................................	0	10	27	47
+15260	PF15407	Spo7_2_N		Sporulation protein family 7	Coggill P	pcc	Pfam-B_51974 (release 26.0)	Domain	Spo7_2 constitutes a different set of fungal and related species from those found in Spo7.  This domain is found in general at the N-terminus. In many members the domain is associated with a Pleckstrin-homology - PH - domain.	25.00	25.00	26.10	45.50	24.20	24.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.97	0.72	-4.51	30	67	2012-09-10 15:57:22	2012-09-10 16:57:22	1	2	66	0	46	70	0	65.60	35	6.14	NEW	cthsIP+sSFTAhRLsYsSspcLShoS+slhLGsIPphWhps+ppshh+sh..hph.sppps+ppspssp	......p..hslsppSaTA.+Lp.........asSPpcLphoSRphFlGsIPctWhps++cpha+sh..hph.pphpsRptohss.p...	0	6	20	38
+15261	PF09061	Stirrup		Stirrup	Sammut SJ	Bio::Pfam::PfamLiveDBManager=HASH(0x4ef6130)	pdb_1dq3	Domain	The Stirrup domain, found in the prokaryotic protein ribonucleotide reductase, has a molecular mass of 9 kDa and is folded into an alpha/beta structure. It allows for binding of the reductase to DNA via electrostatic interactions, since it has a predominance of positive charges distributed on its surface [1].	25.00	25.00	25.20	150.50	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.62	0.72	-4.07	3	5	2012-09-10 18:18:52	2012-09-10 19:18:52	1	3	5	1	3	5	0	79.00	80	4.54	NEW	GuFGLoLNFNAFKEWAS+YGVEFKTNGSQTLAIIsNEKVSLGQWHsRGRVSKAVLVKMLRKLYEsTKsEEVKRMLHLIE	GsFGLoLNFNAFKEWAS+YGVEFKTNGSQTLAIIssEKISLGQWHTRGRVSKAVLVKMLRKLYEATKsEEVKRMLHLIE	0	1	1	2
+15262	PF15408	PH_7		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:P78953	Domain	This Pleckstrin homology domain is found in some fungal species.	20.00	20.00	20.10	20.20	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.23	0.72	-4.15	2	2	2012-10-04 00:02:25	2012-09-11 13:50:59	1	1	2	0	2	11	0	103.00	27	10.99	NEW	EGYLYh.Ecuulp+RFshLpuK.hsh.t-KGG..LsoFpLppolluhPhsphppAssN.GlsA.GhLhhusstc+lphFAsStcshppWlpshNp.uhtls+uo	..........EGYLYh.....E..cuulp....+R..FshLpuK.hsh.t-KGG...L.soF.pLppolluhP.hs.phppAs.sN.....GlsA.Gh...Lhhuss.tc+lphFAsStcshppWlpsh.Np.uhtls+uo........	0	1	1	2
+15263	PF15409	PH_8		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:O13944	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.96	0.72	-3.91	11	458	2012-10-04 00:02:25	2012-09-11 14:08:28	1	13	185	0	226	895	10	89.10	43	10.24	NEW	GlLLKKRRK+hQGas+RaFsLshptuTLSYa+sssus..sLRGphPlslu.lIuANtcsREI.IDSGhEVWpL+ApNcpDFpsWscAhp+s+	..............GalLKK.R+h....LKGW+KRaFsL...-s..GhLpY...h+...sp...pc..h.........+l..+....Gu....I.s......l.u....Lu....lh...S.....l.p....K....+.u...+...c........I...-...L....D.o...t....p..c...I...YHLKspopc.FptWVspLcp..pp..........	0	44	84	151
+15264	PF15410	PH_9		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:O13690	Domain	This Pleckstrin homology domain is found in some fungal species.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.46	0.71	-3.95	16	917	2012-10-04 00:02:25	2012-09-11 14:15:48	1	73	189	3	531	1121	1	111.50	33	7.42	NEW	YKpGalhRKhhh-ssup+sPhG+RuW+hhYshL.+shVLYLaKs......Ep.................thcsuphpp..o...........hpNu.....IplHHuLApp..AsD....YsK.KpaVF+LpTA-tupaLFQTssscEhQpWlcsINaVAA	..................................................................cGhLtRK.p.c..h-s..s..s.K+..s.........upR..uWcph....YsV.L..cst....LhhaKD.......pp.............................................................................p..tpu.h.st.....t............................................hcps........lsl....+.c.A.lssh......As-..........Y.p..K...+paVF+L.....p.hs...D..sspaLFQApsp--MpsWlptI..................................................................	0	135	197	357
+15265	PF15411	PH_10		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:P40995	Domain	This Pleckstrin homology domain is found in some fungal species.	27.50	27.50	27.70	27.50	27.10	26.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.47	0.71	-3.91	39	249	2012-10-04 00:02:25	2012-09-11 15:43:54	1	24	148	0	185	253	0	117.60	29	12.77	NEW	l-pFGpLLLaGhhsVh..K......s.......ct..E+EaclYLFEclLLCCKEhpss..+......ppsp....p.uht....p.t..........p....ppps+LpLKGRIahp.s.l.sclhsh.u.c........s..GpasLpIhW+uDst.l-sFhl+FpsEEphcpWtssl	.............................ppFGcLhhaGphpVt..+.....................s.....pp..pE......hcsYL.....F..pchLlCsKEhpss...p...................pptp....ttt.t.t........................................tppps+hpLKGRIhhp..pl.pclhsh..s.p........................sphpLplth..............usst..lssFhl+aps-cphcpWppsl......................................	0	52	101	157
+15266	PF15412	Nse4-Nse3_bdg		Binding domain of Nse4/EID3 to Nse3-MAGE	Wood V, Coggill P	pcc	PF08743	Domain	This family includes Nse4 and EID3 members [1], that bind over this region to the Nse3 pocket, in MAGE family Pfam:PF01454 [2].	18.50	18.50	18.70	18.50	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.40	0.72	-4.12	87	205	2012-09-12 13:26:22	2012-09-12 14:26:22	1	7	173	0	145	200	1	64.60	27	16.30	NEW	DuchLV.so-Lutc+sppLphs...ssuhDs-cFls+hhsaMttp..............ssttsssppp	....Du+hLV.AoDLutc+sppLp.s...tsuhDhccFlsphlsaMttp.ht............tp..........ttt.p.....pp...........................	1	37	65	107
+15267	PF15413	PH_11		Pleckstrin homology domain	Coggill P	pcc	PF00169	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.50	0.71	-3.82	7	262	2012-10-04 00:02:25	2012-09-12 14:36:45	1	17	124	6	153	1119	8	108.70	26	18.63	NEW	hcGalh....+pts+..hpsW+pRahlLc......sshhcYYcs.................................pcshhptshphuhphhplps.t....sshphphppphth.............s.tpphhhpscsp-pphsWlptlppt	..................pGhhp.....Kh..s....sp.....tc....ua+pRWFsLc.......-tpL.YaKs............................................................................................s......h.c..sh..t.p..........tp..s....t..h.....u.s.c..t..p..t........h..s....s..hpsh.........ssp..u.p..p....h....t.c.s..h..ol.......................................hTs.p.+.phhhpscocc-pt-Wlpulp..s................................................................................	0	36	80	107
+15268	PF15414	DUF4621		Protein of unknown function (DUF4621)	Coggill P	pcc	JCSG:Target_394740-GS13541A	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 350 amino acids in length.	27.00	27.00	767.00	766.80	21.10	18.70	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.15	0.70	-5.75	4	5	2012-09-14 08:43:32	2012-09-14 09:43:32	1	1	5	0	1	6	0	329.00	99	93.47	NEW	YDLSDVNTDDAVMGESWVAPLGTGYVTSDDVVNVEKVPSIREVDGAYVMIYDGEMKIKGKSLRAASsKVEIASEDITTGDIDGLFDGDFVLALTNPHITLKSNVKNASLDCSLSIEAENTSKKEATSSDFTLSTVSPNIWIGPLDPKTDAFKFVKNEKLPGIVQIVPQKIHLSLSADSKQWTNAPADALSELRYAVELPLTPAPEFSAVSVERIEDAFDEDFVDYIFSDGSARIYGEVTNEMPFDMSIEMVIMDENNVPVDIQFPAQEVKGQSGEVIFEITKEDMPKMKDARHIDLNLHLTGRDQGEALKKGQKTTFNLKLKKEGGISI	YDLSDVNTDDAVMGESWVAPLGTGYVTSDDVVNVEKVPSIREVDGAYVMIYDGEMKIKGKSLRAASDKVEIASEDITTGDIDGLFDGDFVLALTNPHITLKSNVKNASLDCSLSIEAENTSKKEATSSDFTLSTVSPNIWIGPLDPKTDAFKFVKNEKLPGIVQIVPQKIHLSLSADSKQWTNAPADALSELRYAVELPLTPAPEFSAVSVERIEDAFDEDFVDYIFSDGSARIYGEVTNEMPFDMSIEMVIMDENNVPVDIQFPAQEVKGQSGEVIFEITKEDMPKMKDARHIDLNLHLTGRDQGEALKKGQKTTFNLKLKKEGGISI	0	0	1	1
+15269	PF15415	DUF4622		Protein of unknown function (DUF4622)	Coggill P	pcc	JCSG:Target_390149-GS13960A	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 348 and 360 amino acids in length.	20.00	20.00	21.90	495.10	18.10	17.70	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.03	0.70	-5.65	3	9	2012-09-14 08:50:26	2012-09-14 09:50:26	1	1	9	0	2	9	0	313.90	71	89.46	NEW	GKVpV-sQLGGpYuIhS....PDAQTRAssssG.ssL+D....splhLLs-GSTLWLshhcpAKsGTTptT...QGYVVR.TGTGGssoLYPC.psDE.NGcl.I..su..SuTPLYLcAGTYpF+hISPAKAlsoDGKssIcNGEYLlATDsRYTQTtSTslsIotlsp....sNVQslhLNPIIsQTARMpFTI+uG-GVaTLEhLpAGIEISGIQpPlDs....TouaNWos...GDsLPsKlGDKpupVplPupphpTsA-GoLsG-TGVLPTDsRSTPVuVLlNltVNGVPTQYphLlsGpaLLsGHSYNYTsTVKIcsG.ITVlTWQNpSWTsDI-	..DRVRIDPVAGGYYPSIS....PSAQTRGATPDG.ETLKD....RPIFLLEDGSTIRLVVYDDAKNLLEEYS...KAYLVRNAGTSGSSLLYPC.EVDD.NGAV.I..SS..SSTPLYMKAGTYYFRILSPAKALNSKGFVNIGNGEYLLATDDRYTQTAMTAVTITKIDEGGTLNNVQTLYLPPIINQTARMQFTVRAGEGVHTLEMLAEGIEISGIQQPLDN....TTSFDWVN...GDVLPVKVGDQSASVRIT..pATpNADNSLVAHTGVLPTDARSHSISVLLNLKVNGNPTQYQMLLTGLYLTAGHSYNYTATVKISNG.VTVLTWQNRSWTENV.V	0	0	1	2
+15270	PF15416	DUF4623		Domain of unknown function (DUF4623)	Coggill P	pcc	Jackhmmer:269656	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 470 amino acids in length. There are two conserved sequence motifs: HLL and RYL.	27.00	27.00	699.10	698.90	26.80	25.60	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.49	0.70	-6.11	6	9	2012-09-14 09:54:18	2012-09-14 10:54:18	1	1	9	0	2	9	5	445.00	55	94.19	NEW	-DYPtShs.uPY-T-LLSIKIlNAGssGspVVEGTIDE-sKpINFPRLDstTNFSAL+lEAcLSsGApLpppVhDhoM-EtsspKTlVLRVlNpsRYK-YhhKlRK+VPVaGADFEpPTVYsFS....GDs....lYssFsohLTRsAuFDGcaVLlVoRsss....tPHLLKVS-LKtGcIsPI.LDlTGVoGGTasYNMGALsNGHlYlASLSGups.SPLKIYYW-TPTSsPEVIAcINVusIPGAGsRHGDNhSlNLDcNGNGYIFFGDNAuoclLRlsluNaKols.s-spllPssscsshhoslaRltNTupYLaoGlchPloLlDpuhsspa...phs...ls...sEulAPRlhsFNpERYLIsCTAGpGuAoKAossLhVYDITKGsTlp-ALppF-pu-pHpPVYpFlLGGuGNsAPusQTsaYIEKDANGKDAKLhlFASRo-SGFVIsEFPlK.	-DYPcSh..uPYDT-LLuIKIlNAGssGspVVEGTIDEspKpINFPRLDstTNFSALplEAcLS-GApLpppVhDhoM-t-sspKTllLRllNpsRYK-YhhKVRK+VPVaGADFEcPTVYsFS....GDN....lYsDFs.sh.hTRCAuFDGcHVLlVoRsss....tPHLLKVSDLKtGcINPI.LDlTGVoGGTFsYNMGALsNGHlYlASLSGu+s.SPLKIYYWETPTSpPEVIAsINVusIPGAGsRHGDNhShNlDcNGNGaIFFGDNAAochLRlsluNaKTVs.spsplLPucscsshsoNlYRltNTspYLaSGlchPlTLlspuhsppa...p.s...ls...sEAVAPRlhsFNpERYLlsCTAGhGuASpAo.sL.VYDloKGsTlpEALc+FDpu-pHpPlYpFhLGGuGNGushsQTsaYIEKDtNGKDAKLhlFASRosSGFVIsEFPlK..	0	1	2	2
+15271	PF15417	DUF4624		Domain of unknown function (DUF4624)	Coggill P	pcc	JCSG:Target_390388-GS13780A	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.	25.00	25.00	122.10	112.60	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.48	0.71	-4.54	4	12	2012-09-14 09:57:47	2012-09-14 10:57:47	1	1	11	0	1	10	0	126.80	68	85.31	NEW	KsNtsphNsu-stEstpholEMEhstNYssSDPF.NuRLFCVScDl-sLsAEloFQMDG-pGIVEIKDpcoD-VLWSNsWcG+VsuDTaolSLsNLpK-KEYsVpFTGTKINHAlVcVSFESsLVpEKERPS	KoN-S+hNshsscEoupTTIEM-LDKNYDTSDPFVNuRLFCVSpDIDlL-sElSFpMDGDSGIVEIKDNKTDEsLWSNTW+GpVssDTFoISLsNlQKEKEYslpFTGhKINHAVVKVoFESsLV+EKE+PS.	0	1	1	1
+15272	PF15418	DUF4625		Domain of unknown function (DUF4625)	Coggill P	pcc	JCSG:Target_390125-GS13882B	Family	This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.	27.00	27.00	27.00	27.00	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.81	0.71	-4.03	44	136	2012-10-03 16:25:20	2012-09-14 11:44:52	1	3	77	0	34	134	4	125.00	28	71.81	NEW	sSC.sc--..........Ds.pcPsIsht................PpssphhptGcs..lpFchploDsttLuuasl-IHpNF.DtHoHsspstts...............spsasappsa...........slststp.....shph+pcIsIPs-.....sssG-YHhhlplTDpsGpppht.shsIpIp	.........................s.uCsps-p......DsppP.hIphh.................pssphhphGsc..lHhc.hplss.sstlpshpl-I.......HsHstp...................stsasappsa...........shsstpp.....shpa+ccIsIPus.........sssGcYHhhlhlsDtsGspsh.hstslpl.........	0	19	30	34
+15273	PF15419	LNP1		Leukemia NUP98 fusion partner 1	Eberhardt RY	re3	Jackhmmer:A1A4G5	Family	This family of proteins includes leukemia NUP98 fusion partner 1, the gene encoding this protein is involved in a chromosomal translocation with the NUP98 locus in a form of T-cell acute lymphoblastic leukemia [1].	27.00	27.00	56.30	56.10	19.30	23.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.33	0.71	-4.18	12	48	2012-09-14 13:29:50	2012-09-14 14:29:50	1	2	25	0	18	37	0	150.80	60	94.99	NEW	DDDDV...SFAKWMSSFWGHSWh-EcE+tlRc+..+puQpsupR+sSLPCP...h..ssL.........P....................phhsS-ph...................PRRHS+EDQsFRs+sHh+shRcsSsDuSF+-PhcscsRSHS.IQcFSESFEQQLChRTKRSVSLuPEuRKERpEREsLRh.ch+S+KKscERRsS+KEEctEA.hssLhcK	.DDDDV...SFAKWMSSFWGHSWp-EcpRuLRc+..+psQssscRKsSLP..CP....h...shh..........P..............+h.SSDph.PRRHSHEDQcFRC+oHh+shRchStDuSF+-PhcscsRSHSKIpcFSESFEpQLCFRTKRSsSLGPEuRKERsEREpLRh.ch+S+KKscEcRsS+KEEcuEAhMusL.EK...	0	1	1	6
+15274	PF15420	Abhydrolase_9_N		Alpha/beta-hydrolase family N-terminus	Eberhardt R	re3	COGs (COG4425)	Family	This is the N-terminal transmembrane domain of a family of alpha/beta hydrolases which may function as lipases. The C-terminal domain (Pfam:PF10081) is the catalytic domain [1].	27.00	27.00	37.50	28.00	26.00	26.20	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.14	0.70	-4.58	27	350	2012-09-14 14:16:58	2012-09-14 15:16:58	1	4	283	0	95	257	8	196.00	35	35.63	NEW	LTPSLlPRsalhQGlluGlshAlGYulGs......hhthlh+hhtlsphtshssp.....thphshsssssssslhhlh.ustWQsslpslMGhtshsshshhtsshlAllshssllhluRLlpthh+hlsthltRh..lPtcl...utslGlslllsLhhslssGVlhRthhpshspsapthsthhcsssstPppPt+SGSssSLlsW-sLGppGRsFVuuGP	............................................hTPSLlPRs.hhQullsGhstAhGYulGs.........hhhhlhc...hh.h......p.t....s.p...................................hhh.shhshsshhhlhhh.lhs.s....tWQcslpclhG.ls.phsh.h.shsl.sshlullshsshlhluRhltth.hR....hLsp.t.lpRh....ls.t..l...usslslslslsL.hlh.l.hNsVll.+tshsuhspshutsNs.psssspssPs.oPhRSGSPuSLhoW-u.LG+pGRsFVssGP..............	0	22	67	84
+15275	PF15421	Polysacc_deac_3		Putative polysaccharide deacetylase	Coggill P	pcc	JCSG:Target_416920-SP13771A	Family	\N	27.00	27.00	28.00	84.50	26.10	23.50	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.26	0.70	-5.79	8	18	2012-10-03 16:37:10	2012-09-14 15:30:07	1	3	16	1	3	20	1	428.50	40	52.98	NEW	uEIsIshsssl.stsslslEIPPLKYNKchlhhhTQDDCp.AAashTWAAINGKPlosp................haacls.......HLptsDhP......PDhYhhs+sLusTDGsGpEVRFuhTsolus-...-pYMspcstlphGaTp-YaRFah+shlhWc-l+-hhNYGsuIAaHDVssh-h-ss.splht+aslupsl.Ihc+LsGRsCKhLuE.PNGs+sYlsAAhspDsIQTITAQuGs...hKlYPFpsstsLpK..sslpRhFhsss-.........h+psItcphu..pssE-RpAI..sIGsHs.......TDusWss...hLhWLNssYG+cGsDslWFPspEEYYEY.YhRpaopss.Kplspssl+LTVplPutcs..FYYPSlTlNLsGlp.h-hsSlpSs-sVTGLSYu......stcstlMlNlDCR+hLsEHAE+FVcpYEAs.ostus+ADAhYFVsMLK-SsKKstLhpRIp	..sEIsIchpssl.stptl.p..lEIPPLKYNKchlhhhTQDDChpuAashTWAAINGKPlSpp................haacls.......HLptsDLP......PshYshs+oLusTDGsGsEVRFuhTsTlus-...-paMspcohlp.GaTp-YaRFah+shLhWc-l+EhhNYGsuIAaHDlpsh-hcss.splhtcasluQsh.Ihc+LsGRsCKhLuE.PNGs+sYl....pAAhshDsIpTlTAQuGs...hKlYPFpsstsLpK..sslcRtFhsusc..........hKpsItc.hp...Ps.E-RpAI..sIGsHs.......TDspWss...FLhWLNcsYG+DG-DSlWFPopEEYYEY.YYRhpophs.KplsssolKLplpLPup.cs..FYYPSlTlNlpGlphh-IhSlpSs-sVTGLSYu......sacstlMlNIDCR+hLhEHAppFVcpYEAs.ost.s+ADAhYFVsMLK-SsKKstLhpRIp.....	0	2	2	3
+15276	PF15422	DUF4626		Domain of unknown function (DUF4626)	Eberhardt RY	re3	Jackhmmer:A1A4T8	Family	\N	27.00	27.00	57.80	57.70	25.60	22.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.91	0.71	-4.22	3	11	2012-09-14 14:52:08	2012-09-14 15:52:08	1	1	8	0	2	6	0	102.50	74	87.51	NEW	MTGRMATLEKSHSSACWRKRSSRTCVEPDRTQDAIHEPRGLSRSHTVLRHRHFVFLPLSSGA+PSVPPR.....shhtscssGslphssPu.hhhhps.hhpthpphhh..hL....tKQhAcscsppPRuspSlhcsAD+LsW	hTGpMATLEKsHoSACWRKRSSRTCVEPDRTQDAlpEPRGLSRSHTVLpHRHFVFLPLSpGA+PSVPPR.....s.hh.c...............................................................h.	0	1	1	1
+15277	PF15423	FLYWCH_N		FLYWCH-type zinc finger-containing protein	Coggill P	pcc	Jackhmmer:Q96CP2	Family	This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with Pfam:PF04500. There are two conserved sequence motifs: EQE and QEPS.	27.00	27.00	29.90	29.80	18.80	17.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-3.88	10	49	2012-09-14 15:06:59	2012-09-14 16:06:59	1	5	20	0	23	51	0	98.40	64	23.19	NEW	MPLPEPSEQEGESlKAGQEPS...scPGT-VVP..AAPRKPcEFScLVLLTsSpps.sDsssocPp-VHCVhSLEMuuPATLAs.TLQILPsEEQspllQPsPp.sEQK+SKlD	..MPLPEPSEQEGESVKAGQEPS...PcPGTDVVP..AAPR...K..PRcFSKLVLLTASpps.tcssGuK.ptVHClhSLthsGPATLAp.sL.hl.sEtQ.RslpsuPptPEQKRSK.D.....	0	2	2	2
+15278	PF15424	ODAM		Odontogenic ameloblast-associated family	Eberhardt RY	re3	Jackhmmer:A1E959	Family	\N	27.00	27.00	43.60	43.60	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.82	0.70	-4.90	12	37	2012-09-14 15:07:17	2012-09-14 16:07:17	1	1	24	0	16	27	0	246.60	65	94.37	NEW	APLIPQRLlSASNSNELLLNLNNuQLh....PLQlQ.GPhNSWIPPFoGlLQp.QQQAQIPGLoQFSLsoL-.pFAGLhPNQlsFPGQsuFAQGsQssQlDPSQ.QTPsQTQQGPspVMPYVhSFKhPQEQuQMhQYYPVYMLLPWEQs.QTsspSP.QTGp.Q.F...EEQlPhYspFGYIPQQsEPshPGGQQQhsFDP.hlGTAPEhAsMPsttVlPYLQKEhINF+HssAGlahPSTS..KPSTsshFTSulDP..TIsPchhEcKAKTDSL+EP	......APLIPQRLhSASNSNELLLNLNNuQLh....PLphQ.GPhNSWIPPFSGlLQQ...QQQAQIPGLoQFSLSsLD.pFAGLhPNQIPFPGQsSFAQGsQAGQhDPSQ.QTPsQTQ.GPs.p.VMPYVFSFKMPQEQuQMhQYYPVYMLLPWEQPQQTlspSP.QTtQ.Q.a....EEQlPFYsQFGYIPQ.AEPslPGGQQQLAFDP.hLGTAPEhAlMssGt.lPYLQKEsINF+HssAGlFhPSTS.sKPSTTNsFTSAlD...TITPcl.EcKsKTDuL+EP.....	0	1	1	2
+15279	PF15425	DUF4627		Domain of unknown function (DUF4627)	Coggill P	pcc	Jackhmmer:217257	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 230 amino acids in length. There is a conserved WYK sequence motif.	21.80	21.80	23.80	23.40	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.64	0.70	-4.82	3	20	2012-09-14 15:08:15	2012-09-14 16:08:15	1	1	20	1	2	15	0	213.20	76	92.30	NEW	sGlpAQNLIKNscFD.T-LsTEhTsAspsTsG-WFAhNDEssGsTTISactTsDcK+GNAlcl..SussKssSWYKAFLGQRlpsGlEKGlYsLoFaAKAc-sGsQV+VFIR.....+ssNGKssspFFMRcsaDh..-SQPNpSuApYstsIKKA...GKWTKVolsFDFGKVVNAIuShKu..Ncst-VT-TDsssAhLKDFsIsIQ.SQoKsSsVLIDsVSLKK	....VSVSAQNLIKNEKFA.TEVKTKVTNANKATAGEWFIMNNEADGVTTIAWEpTGD..AKYPNAMKLDNSGAEKNlSWYKAFLGQRITDGL-KGIYVLTFYAKAKEAGTPVSVYIKQTNEEKNDNGKYNTTFFMRRDYDA..DAQPNASGAQYNFKIKDA...GKWTKVVVYYDMGQVVNAISSKKA..NANLEVSDTDDDAAILKDCYVAIL.SQNKGGVVEISDVTLKK.......................................	0	1	1	2
+15281	PF15427	S100PBPR		S100P-binding protein	Coggill P	pcc	Jackhmmer:Q96BU1	Family	S100PBPR is a family of proteins found in eukaryotes, and localised to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridisation shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.	27.00	26.40	48.50	26.40	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.44	0.70	-5.39	9	68	2012-09-14 16:09:37	2012-09-14 17:09:37	1	3	29	0	29	67	0	252.40	51	84.12	NEW	NAPF.SWu..SL..DEDtLDDSLLELS-GEEDDGHFSaTEEEIpELLKDDD.SsEpp.ht..hhcDD..uscsEKGE+tSQILLDTPQEKNSLYSLGPsAETPulaKLPQLSTSlGHGPoPoKsLNR+FsLEKNLIKlT.V.APFsPTVCDslLDKDKTD....SSKDTEK.......sSSLGE-hRE-sLusNESKLCTESEsISPsNSAW-GPshsS.SNssFpQTVSDKNhP-SK+PTPVFSQI.DHSEoPs.su.Sh+NuGSHKSusEhR.PVVSSSSp.K.csLDKDSGKhKGpERRLGKVIPVLQsKsRTNVsTFSQS-LEQQKQIYL+sVIAHIEDPhDSNQGsLGELhALMDQV....HHMQN.+WQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNhRSHHRFQRL	......................................................................................................................................ssh.SWs..o...DEDtLDDSLLEhS-GEEDDGchsaTEEEIp.LLK-D................t..st...p.Eht.+tSpIh.-sPpE.N..S.hSLGPsAETs.shhKLPQLsss.upt.......sR..s.EKshlKlT.V.sPFpshlhDshLsKcch-....SSK-hpp........usht-phpcts.t.sptp.hot....pst...........................................................p.stthp..hspospt.p..hhsh.....s.tp..........h.pp+hupl.sh...sttR......hSpspLEpp+.p.YlppVhtHlpp..t.pps..hEL.sLhsp.....h..p....p..hQHPSDhThRNY.h.ppp.h..hSLppW.......................................	0	1	3	6
+15283	PF15428	Imm14		Immunity protein 14	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with mostly all-beta fold and several conserved hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1 or Tox-HNH family [1]. The protein is also found heterogeneous polyimmunity loci.	23.30	23.30	23.30	23.40	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.90	0.71	-3.74	70	172	2012-09-18 20:10:21	2012-09-18 22:06:20	1	3	152	0	38	165	2	121.50	18	51.88	NEW	..GDlFslsLs..sspauhGpll...shtths+............hhshhhsps.......p.hph.hpphp.shs..lcth.....hh..hhh.hcpshhpGc.....Wc.lIGppshtptptt........slhahh..shs................hpthp.h....sh...ph..p........t.....	........GslFshsl...tspauaGhll...shttht+............hhshhhshs.......p.hph.hsp.p.sl.s..lp.l...t.hh.sthh.hcphhhpGc.....a..IIGphshtptch.........sh.a.h..shs..............htthpth....s..ph..p......t..........................................	0	15	24	26
+15284	PF15429	DUF4628		Domain of unknown function (DUF4628)	Eberhardt RY	re3	Jackhmmer:A1L170	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 152 and 673 amino acids in length.	26.00	26.00	27.60	26.20	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.04	0.70	-4.97	10	42	2012-09-19 13:37:54	2012-09-19 14:37:54	1	2	32	0	24	34	0	220.80	60	57.31	NEW	MFENhNsApsPKLQpS+ShspLo+ssususu.shGssEPuGPulhsGSSQHLK...NLGKAVGAKVNDFLRRKEPuuLGs.lGVhEVNKoAuApLuuusssspsshh....psctSh..EuFPRLDPPPPss+KRTPRALKTTQDMLISuQPVlSShEtuppsssupspco.spsps....sptsstpsE.ussppttpscsLsNG...................EsoL.SVPDLIHK........Dup--s+l+so-sR+uSoPs.hEpsGlKlSLS.hsLtE...psuuPsspuRTsSLDsEGPHPDLLSFE	.................MFEN.Nss.sPKLQtS+ShspLo+ssusssh.s.ussEPuGPulhsGSSQHLK...NLGKAhGAKVNDFLRRKEPouLGu.VGVhElNKTAuApLuuGscsssssh.....pscpSs.pEuFPRLDPPPPlT+KRTPRALKTTQDMLISSQPVLSShEhusp.ssupsp-o.stsps.......t....c.sshth.tpscsl.NG...................E.sL.SlPDLIHK........-sp-.shhp.sp.R+sSSss.hcp.uhK.SlS.hpLhE...psssss.tsRssSlDsEuPHPDLLSFE......................	0	3	5	10
+15285	PF15430	SVWC		Single domain von Willebrand factor type C	Coggill P	pcc	Jackhmmer:P0C5F3	Family	SVWC is a family of single-domain von Willebrand factor type C proteins from lower eukaryotes. The canonical pattern of most von Willebrand factor type C (VWC) domains is of ten cysteines, however this family, largely but not exclusively of arthropod proteins, contains only eight. SVWC family proteins respond to environmental challenges, such as bacterial infection and nutritional status. They also are involved in anti-viral immunity, and all of these functions seem linked to SVWC expression being induced by Dicer2.	27.00	27.00	27.30	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.59	0.72	-3.53	127	301	2012-09-19 13:48:04	2012-09-19 14:48:04	1	5	52	0	121	307	0	67.30	24	53.12	NEW	Ch..a.p..sp..hlss.Gtt.....hp.....pp..sCpphpCp.....pp..tplp..lpsCsth..s....st..sC...phtp...sssts.a.PpCC...phhC	........................C.hp..st...hltsGpp.....hp......ps...CtphpCp......pstplp..lpsCshh..s......sssC...chts.......shsts.a.PcCCs..phhC........	0	34	41	86
+15286	PF15431	TMEM190		Transmembrane protein 190	Coggill P	pcc	Jackhmmer:Q8WZ59	Family	\N	25.00	25.00	89.10	80.50	23.90	21.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.72	0.71	-4.23	3	18	2012-10-03 17:26:12	2012-09-19 14:49:08	1	1	17	0	10	16	0	125.60	72	76.72	NEW	GNGIQGFFYPWSCEGDVWDREACGGQAAIENPNLCLRLRCCYQEGICYHQRPDENMRKKHLWTLSLTCuGLLhLIFLICFFWWAKRRGLhKpLKMPGhLS+hKKsKlSRsVSpoSssphoLpcKcpSPLLus.sG	......GNGIQGFFYPWSCEGDVWDRESCGGQAAIEsPNLCLRLRCCYRDGVCYHQRPDENMRRKHMWALGWTCGGLLhLIsSICLFWWAKRRDh...LHhPGFLtG.+CD.LS+oVSLLSKcRGTtcp...........susss.......	0	1	1	1
+15287	PF15432	Sec-ASP3		Accessory Sec secretory system ASP3	Coggill P	pcc	Jackhmmer:Q9AET7	Family	Sec-ASP3 is family of bacterial proteins involved in the Sec secretory system. The family forms part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell-wall glycoprotein adhesin encoded upstream in the same operon.	27.00	27.00	39.30	39.30	26.00	21.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.50	0.71	-4.18	38	390	2012-09-19 13:50:34	2012-09-19 14:50:34	1	2	375	0	22	205	2	123.30	46	50.80	NEW	oYhYGSplpapspspVpFpNsLhPSGphI+sWtStsNaQu.sRtsPsLPLL++GppYclphsh-sp..Ppsulal+lhFaD+hscplpphlh+spp..hpFsYPccAYsYpIpLlsAGhpplsF+plpIp-hp	......TaMYGSpVsaps.scVpFhNPLMPSGhsIHpWh.hppFpp..h+.osPsLPlL+RGpcYpLphsF-sp..PtsoVYhhIhFas+pupcLuppIlKsps..hshpYP-EAYuYclphhsAuspSLhF+sloIpEh.s.......	0	7	8	18
+15288	PF15433	MRP-S31		Mitochondrial 28S ribosomal protein S31	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q92665	Family	MRP-S31 is the mitochondrial 28S ribosomal subunit S31. This family of proteins is found in eukaryotes. Proteins in this family are typically between 246 and 395 amino acids in length. There are two conserved sequence motifs: RHFMELV and GLSKN.	27.00	27.00	30.40	30.40	20.30	25.20	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.18	0.70	-4.99	29	122	2012-09-19 13:52:14	2012-09-19 14:52:14	1	6	87	0	76	120	0	254.30	40	76.53	NEW	spccLhslltuMKl-.lssp......p.h......pps.c..tpp.h.cshpsssuhhp+spp-us...p.ps-slss-LlsAApsVAsoLs...s-+p.pTESELLppLhpHcspspspppt....................pppcls.......hu.slIusMK.......ls+ssst+...hss...................Rssp...pIpFc-p.tcshs....pcc........c.stsh+p..........chsLFsG+pLsIFssts....cpsspstst.olW-h.ht+pLuhsspQPPtNtFEEMIQWTcpGKLWcFPIsNEtGh--E.ss.cFpEHIFL-+HLE.sa.P+pGPIRHFMELVssGLSKNPYLoVcpKhEHItWFR-YFppKcDlLKEs	.........................................................................................................................................................................s...................................................tt...t.t.hpct.t.t.......tc..shs.plltAspslAs.Ls.....cpp.p...scSELLtpL.t+pptststttt.............................................................................tt.ph..p.......hp.pll.sshK.......ls+ptt.p....t.........................................p.p........p.phcpt.pt......tpc...................p.t.hpp.....................................phslap..u..c...Ls..IFp.tt.....t.....s.st.shWsh..t+...pLsh.hs.........p.ps..s.tNtFEEhIpWTcpGKlWcFPIsNEt.Gh---.ss.pFpEHlFL-cHLE..sa...P+pGPIRHFMELVssGLSKNPYloVppKh-HItWFRsYFppKc-lLp-...........................	0	27	33	55
+15289	PF15434	FAM104		Family 104	Coggill P	pcc	Jackhmmer:Q969W3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 113 and 185 amino acids in length. There is a conserved SLQ sequence motif.	27.00	27.00	43.40	43.30	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.57	0.72	-3.86	10	68	2012-09-19 13:53:57	2012-09-19 14:53:57	1	1	32	0	30	93	0	113.20	66	80.69	NEW	RKRRR............sGsEEDsalsPQsKRss......+NslhQDsaDTE.....................SSSSDstp.......SSSuINSP-RA...........SG...PEsSLNQhssssusNh.PQ.hp.EpSAlC..QGPYsHINQlLKEAHFaSLQpRGRP.PT	........................RKRRR.NGsEEDNHlsPQoKRSS......RNPlFQDSWDTE.....................SSuSDSGG......SSSSSINSPDRA..............SG...PEuSLsphhsGSuPNT.PQsh..EQSALC..QGsYFHINQTLKEAHFHSLQHRGRPsT....	0	2	4	9
+15290	PF15435	UNC119_bdg		UNC119-binding protein C5orf30 homologue	Coggill P	pcc	Jackhmmer:Q96GV9	Family	UNC119_bdg is a family of eukaryotic proteins that probably plays a role in trafficking of proteins, via interaction with unc119 family cargo adapters. The family may play a role in ciliary membrane localisation.	27.00	27.00	221.20	221.00	18.30	17.10	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.26	0.71	-4.96	5	39	2012-09-19 13:59:18	2012-09-19 14:59:18	1	1	37	0	25	31	0	196.10	83	95.14	NEW	MDINGsSRoslSlLP..AAElpSTLKPEAEKPRCSSTPCSPIRuTVSGYQILHMDSNYLVGFTTGEELLKLAQKWSsG-ssKu...EAhPS....slsKsVDlGLHRSSRIYKuKSRYYQPYDIPAVNGRRRRRMPSSGDoCpKSl.Pa.EPtKALHGPLPLCLLKGKRAaSKSLDYLNLDKMsIKESuDTEVLQYQLQHLTLRGERV	.........VDINGESRSsLoTL..PhPsAEssSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEESKG...E.Ah.Po....LRSKQLDuGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSL.PY.EPYK....ALHGPLPLCLLKGKRAHSKSLDYLNLDKMsIKEPADTEVLQYQLQHLTLRGDRV	0	1	3	10
+15291	PF15436	PGBA_N		Plasminogen-binding protein pgbA N-terminal	Coggill P	pcc	Jackhmmer:O25249	Family	PGBA_N is an N-terminal family of bacterial proteins that bind plasminogen. This activity was identified in In Helicobacter pylori where it is thought to contribute to the virulence of this bacterium. Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a Pg activator.	27.00	27.00	69.90	69.60	23.00	22.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.48	0.70	-5.07	27	196	2012-09-19 14:39:47	2012-09-19 15:39:47	1	5	194	0	21	117	2	213.50	51	74.30	NEW	hpslcsslhtV-stt.sh.lphpu.clpVGpSGhVlpph.ss.pssIlApAsVhph..p..sGhApl+apsF-sLpQcALPpPphhPptGDcllLsahYsRullIAPsp-hYpplpssas.slpFlHsDlhuuaL...ss....sPp+cDF++hCst.ulGLlalshssch.hlDCpSFplLp.pphs.ts.spphphPFYSRlpsI-sshas......hsu.pchpsY.sYYcpLl	....................l.+PlKscLlcVDDhh..Ga.I+.DSsDIKlsSSGVVlp+F.ssspSIIARAuVIsK..c..sGlAKLcFoVFsuLKQ-ALPLPsllP+tGDEVVLNFLYDRuLlIAPD-pTYsclstsFP.pIhFsH.DlhGApLhhsss.h.uPKRuDFRcFCs-sAVGlLhlAL-NpupllDCQsFshL..hEls.lScsossQlPFYSRIuGh+osFFD......FNS.pclsNYYcYYDALl...................	0	5	17	21
+15292	PF15437	PGBA_C		Plasminogen-binding protein pgbA C-terminal	Coggill P	pcc	Jackhmmer:O25249	Family	PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium.  Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.	25.00	25.00	27.10	25.60	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.31	0.72	-3.85	7	118	2012-09-19 15:07:48	2012-09-19 16:07:48	1	5	44	0	3	126	0	85.50	60	25.41	NEW	hcEssspsNuo.....ppptpcN.....APs.KEsNA.KEtsKLssKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALEhNKK	.................................t......ppspts.....ppptscN.....APs.cEsNspKtEpKLsuKEEKRRLKEEKKKAKAEQRAREFEQRAKEHQERDEKELEERRKALEhsKK....	0	3	3	3
+15293	PF15438	Phyto-Amp		Antigenic membrane protein of phytoplasma	Coggill P	pcc	Jackhmmer:Q7M1T6	Family	Phyto-Amp is a family of phytopathogenic wall-less bacterial antigenic membrane proteins [1]. The bacteria are limited to the phloem and pose a major threat to agriculture worldwide. They are transmitted in a persistent, propagative manner by phloem-sucking Hemipteran insects. Phytoplasma membrane proteins are in direct contact with hosts and are assumed to be involved in determining vector specificity. Phyto-Amp is thought to be one family of proteins that mediates such specificity. The proteins appear to be encoded by circular extrachromosomal elements, at least one of which is a plasmid [2].	27.00	27.00	48.60	47.80	21.50	20.40	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.26	0.71	-4.67	3	24	2012-09-19 15:22:09	2012-09-19 16:22:09	1	1	22	0	3	23	0	179.30	70	82.31	NEW	MQNQKTQKSLVAKVLVLFAAVALMFVGVQVFADsPLDLSTLcC-ssLELTANDASDAEKVVsQWKVQNTSLDKKVTKDSVKVtVADNKVTVTPVDuSATSALoGSKVLoLVGVCELNKLTLGTDKKLTLTVKDDKVDAEAGLKALKEAGAKVPATVTKDDLTFTVGKGDDANKVTVKAVDGKTTVSGQVTFEFNV	MQNQKsQKSLVAKVLVLFA...AVALMFVGVQVFA.DDKLDLuTLEC.KssLELTAA.DAuDAEKVVKQWKV..QNT..SLsAKVTKDSVKVsV....AD.NKVTVTPADuDAuKALoGSKlLsLVGVCELNKLTLGTDKKLTLTVKDsKVDAEAGLKALKEAGAKVPATVsKDDlTFTVGKsDsANKVTVKAVDGKTTVSGpVsFEFsV......	0	1	1	2
+15294	PF15439	NYAP_N		Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter	Coggill P	pcc	Jackhmmer:Q6ZVC0	Family	NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8 [1]. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice [2].	27.00	27.00	137.40	34.80	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.86	0.70	-5.28	20	174	2012-09-19 15:53:14	2012-09-19 16:53:14	1	16	37	0	86	128	0	321.70	41	37.94	NEW	AREsDRlRschstshhpcphp.t...stpp-........ssK.tp-tsuht.............RHFR...ushshPhu.Dplsps......su.u.uhRS.SLHSVhSh.D-uuuhs...........SsRKQPPPKPKRDPsTRLSAShEA...........Vu..AsLss......usKcuupt.....hs+PRPHS...D-..ohKKIPP.KPKRSPNT+LSuSaEElsuts...P...u.....spsu.ss...........sht.ph.spsspsssp....................pp.cs.E-EPVYIEMVGssh+stu.........................scuss-puEAVYEEMKY.hs.E-ss..sts...shssuS.Pshpsp..p.hs..h...psth.sttpus..ppssCDIPsPFPNLLsHRPPLLVFPPsPsTCSPsSDESPLTPLEVpKLPVLEs.............s.pashQssuSSP.Ss.Qhstsp.Kusss....Psus.shsshss..usRspSpuTPhP.Pp	...........................................................................t+Ep-thRpp.p.sh.tt..t.....th.t...........sh+.ht..-.tsht.............+Hh+h..u.hohPs.s.-p....h.....sps...........ss.u.usRS.Sh..HSVtuh.Dss.uuhs...........tsp+.pPPsKP+RcPsT+LShS.cs........................................ss..uphss...................................spptssp..........+PpPcu...c-....+KlPP.KPKRsPNTpLSsSa-E.hh.t.......s.........stt...s...sh...........sht.t.....upsss........................sp--EPVYIEMVGshhRsht..........................tpps-puE.ulYEEMKYsl..--hs.......t....s..t...hss...........sS.....s.p.p..................s.h.t...ss..pt..C-IPPPFPNLL.HRPPLLsFPsusspsSssuDpsPlsPlpVp+LPVLp..............s.pa.c.pssuuoP.u......phstppptps.........tsshhh.ss....ssps.opusP.Ps.s.........................................	0	3	11	30
+15295	PF15440	THRAP3_BCLAF1		THRAP3/BCLAF1 family	Eberhardt RY	re3	Jackhmmer:A2AJT9	Family	This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay [1]. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) [2].	27.00	27.00	27.30	27.30	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	646	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.67	0.70	-13.46	0.70	-5.86	22	245	2012-09-20 09:01:36	2012-09-20 10:01:36	1	8	42	0	94	181	0	501.30	34	75.82	NEW	uRSRSRSP..K+RSh.SPtsR.spp+..acp+pSps+h.ssp.......R.....+csppss.phR.hcs-K.pspscp+hssctsst..h+ph..E..c+ususshc.tsh-shhs.ps.p..................p.sh.Pt...tsD.sspRuph.Pphsps.sshccppps.......shs.psps+hh.sshp.ptstpst+ssp.........RSh......usS......+apsp............h+.........psphc.tpph..pppphspS..+cu....s--hpsRoSFpK..RYP..E..Dp-hcphs+ppcRsp..DhE+h.........c.....s+cssR.....ssch......c.cc.uhss...hp-cc...cphshu.psc.RhstR-h.-p.....ups..sK......ohDYc+K++p.hs..cs-pcFsDs........csp+hsccEDpKappptt...s.hs.+.EussFs......ssRsccoc-tps........+c.s.K...scKcshsps....p..ssps-lchcssppKhcp+hc..pp....shR+p.ssspppphspspch..sthKsSssph+c.....cplslKlDst..shDphR..suuShssERphu+DLVtsu+KpppF+slF-HlcS.sQs.pppPotpFsQcIlTIlHpVKtpYFsSsshTLpERFo+hp...css..p-s.+pppsPEIHRRIDhS.upLpp+pph......hpE.......oppshhK........h...DPsDLRHDIERRRKcRhpsc-c+thp......hsSuspRspppS..phpph.ps.cs-tFpKss+hh.+.sphRph.ppPpps........oppppcshpp...ctathcsppcs..cp..ppsFc	..................................................................................................uRSRSRSP..K+RS..S.tsR.spp+..p..+pS.....p..s....ppp.....p.......sp.ss.p.R.hpppK.ptptt.t.........s.ptps....tsh.p...ppt.psp.p..s.ts..php..p..................t.t..st.....ths.sp.pu....s..tt..s.pppp.p.......s.s....s.....s..s..p.t..tsh..tts..p....................puh..................ttu.................phpsp......................p............ps.hp....h..p.tph.ts..pt..............pt.tttuua.........Y...-.....-pcht.......phtch.p+.p..-..cp..................p+tshp.....p.th......................t.c.s.........tc.pp...ths..st+.t..+p.t..pp......sph..tc........p...D.pphcp.t..hh...tpptc...st.............t..p..s.tts.+.p.t.t..........hp.h.E..hht..........ptct.chpp.t.....................tt+pp.t.tt....p..s....h..ph..........ph.......st........c.p..p.......hp...s.s.pp.h....s.ttp.....s.hc....S......h+..........tp.pV+...hc.h..s.D..p...............su..hsp-R.hspsLVtss+Kpp.pF+slFpHlp..sQs.ppssSc.FhQcIlollH.pVK...tpaF.SsshTLpERFoph.......+usppc...p.ppsPEIHR..R.IDl.S.ushpp+.thh......htE........ppts.K.............h.tDssDLRhDI-RR+K....c+.pp...cp.hp......htSs.s...pRppppo..p.pp......cscthpK..p...p...........tp...s...........p..................................................................................	0	3	12	34
+15296	PF15441	ARHGEF5_35		Rho guanine nucleotide exchange factor 5/35	Eberhardt RY	re3	Jackhmmer:A5YM69	Family	This family includes Rho guanine nucleotide exchange factor 5 [1] and Rho guanine nucleotide exchange factor 35.	27.00	27.00	69.70	36.70	23.10	18.80	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.70	0.70	-5.69	11	32	2012-09-20 09:25:48	2012-09-20 10:25:48	1	5	22	0	18	32	0	418.10	51	33.63	NEW	MEAEEPpHGASTPlPAlcEhullPEulMRSSQIPAL-PEAQEGpDPSapWsEGHRLltsQp+-LRDssDaAs-Shs.FPK.EuSsssEosQEsLVAEAsD.TPEpQEuVsQSLsDcpARTlAsPEhhACPlQuEaLDh.sshSocLsoR.VEsEhpPELTSLsLusupA-E..cEEsSPssSspstaaPsCc.cHPuETsps.csutussl+QGEcLQhctsQES...p...G...L...LpPQEAQGLEEQttQEsthQtEGTlpEslCsDGLhGE.p.QhsEp.ssGsEtEQ+QKQEQlQ.D.sh.LG+QGEppGLs..GELEGLssuEhs.EppEpcspspcssEptEppcpEhpuPEEpcssoQstEsQSLlEKSEcVotKQEscGlp...GcshsVEGQE.......E.......EEPGsWDuushushscppsspEpcE+cGPSsL.AhVAPEVsSPsDLFP-sShPhopIPGTQpEP..tAEELSPtALsPsLEPscWSaQPlS.PuSFPstESLDscT	..MEAEEsQHGASsPIsAltEhSlIPEA.MRSSQlsALs.EAQEscDPSYKWpEtHRL.tTQQp-LRDVsDaAhEoMsSFPK.EuSu-VEssQEslVAEssD.TPEp.EAsPQSLAsRQARTlAsPELhACPlQuE+LDh.sshSS-LGSc...EVEFhPtLTSLsLGouQAEE..cEEoSsDsSuQTpaassC-.-HPsETsQs.csutSGolRQGEEL..c-hQESp...GLlpP..QEsQsLEEQGpQE.sshptEGTLtEslCuDGLLGE.p..QMhEQ.lNspcGEQ+QKQEQlQ.DshLG+QGER.tLs..sE.EGLNsuEhtpEphEpcspsQts.cptEtpcpEhphPEEpcssuQspcsQ.ohhtKSEcVotKQEspGhp...tcshslpsQE.t.......cE.tshDusthss.s..ttpstEEtpEHcGPsh..s.lAPEsss.sDlFPsssh..ho.pI..PtTQpEs..pAEELoPtA.sPsLEPhthSaQPhS..uSFsstES.DpE..........................................................................	0	2	2	3
+15297	PF15442	DUF4629		Domain of unknown function (DUF4629)	Eberhardt RY	re3	Jackhmmer:A6NCI8	Family	This domain family is found in eukaryotes, and is approximately 150 amino acids in length. There are two conserved sequence motifs: MHML and LGKK.	27.00	27.00	44.60	42.40	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.08	26	89	2012-09-20 12:35:51	2012-09-20 13:35:51	1	2	25	0	50	72	0	142.30	49	19.49	NEW	usS-psRKNKHKASE.lsuAPcAKIQscs.-sLltGEss.lssAsuS-+AstshAK+pssKs.KsAsuRss..ps+upGQ-+s++spENsoKKstEpKQSss+V.KAEEKPsIPKpKRK+s.PELSQEsFKKPRosLGMHMLESVQVFHsLGKKs	..........s.SDQsRKsKHKASEPlpGAPcAKIQscss-sLltGEss.lssAsuS-+AssNhAK+sssKspKuAuSRss...psKupGQE+sKpsp-NsSKKspEpKQSss+V.KuEEKssIPphKRK+s.PELoQEoFKKPRosLGMHMLESVQVFHsLGKK..........................	0	1	1	5
+15298	PF15443	DUF4630		Domain of unknown function (DUF4630)	Eberhardt RY	re3	Jackhmmer:A6NCS6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 124 and 286 amino acids in length.	25.00	25.00	25.50	25.50	24.00	24.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-10.98	0.71	-4.41	6	29	2012-09-20 12:49:22	2012-09-20 13:49:22	1	1	25	0	18	23	0	138.90	47	63.95	NEW	GA..ALVGVLVAEAuPEDAVAP....tLRLLEALLRsVFGRQAGG....PVQAAAYsPGpPA.SSLAVQsAACRALQAAGPu+PAEGAWERPGLPuLLACFSWGPWS.RtKs.ssous.suPsQschQ-sEEELALTulaPNGDCED.sG+GStApDGlsp.sPs-PsGDo	....................................hlGlhhh.st.c-u.su........tlplLEuLLRsVF..G+psGG....sVQAAsYsPGpPA.SsLuVQtAACRALQAAGsucPs-u..AhERPuLPuLLsCFSWGPhp..++Kspsssus.psPup-shQ-sEEELALTul.aPNGDCED.hGpGocApDGshH.sPs-PsG-................	0	1	1	5
+15299	PF15444	TMEM247		Transmembrane protein 247	Eberhardt RY	re3	Jackhmmer:A6NEH6	Family	This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 197 and 222 amino acids in length. The function of this family is unknown.	27.00	27.00	30.50	30.40	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.58	0.70	-4.52	7	30	2012-09-20 13:25:11	2012-09-20 14:25:11	1	2	23	0	16	41	0	198.90	71	95.41	NEW	MAsEDREhMEuRGAGESCPThPKhVPsDshsEGKP+ApLEAEs.KPDSSYDaLEEhtsCEDGuCsGPPK........s.sstuuPs.TKGQAGDGP..EssELsh........sPGsEHssEMELEKlRMEFELTRLKYLHEENERQRQHEpVMEQLQ.....pQAss................FSGGLQDLLLPQNQFAMFLYCFIFIHIIYVTKEMlFFLFSKHYLFCIAAILLCLIKTLWS	..........MAsEDREMMEARGAGESCPTFPKhVPuDshSEGKPRAsL...EAES.KPDSSYDaLE..EMEsCEDGGCsGPsK........SLSsKusPs.TKGQAGDGP..cs.uELP.........sPGT...E+.NsEMELEKVRMEFELTRLKYLHEENERQRQHE.VMEQLQ....pptp.....p....l.p......h.s..FSGGLQDLLLPQNQFAMFLYCFIFIHIIYVTKEMVFFLFoKHYLFCIAAILLCLIKThWS............	0	1	1	2
+15300	PF15445	ATS		acidic terminal segments, variant surface antigen of PfEMP1	Rask T, Coggill P	pcc	Rask T, [1]	Domain	ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) [1]. this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.	27.00	27.00	29.60	29.10	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	437	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.78	0.70	-5.37	35	168	2012-09-20 15:35:02	2012-09-20 16:35:02	1	33	2	0	22	173	0	348.00	56	19.28	NEW	STlsaulGluhuohsahaLK...KKTKosV.sLFplLpIPKuDYsIPThKSsNRYIPYsSs+YKGKTYIYMEGD....ouuD-.KYsh.scooDIT.SSESEYEElDINDIYVPuSPKYKTLIEVVLEP.................................o.p........sTQNDIssDsl.PSs..................lTDsEWNpLKcDF......ISphLQsp..Ns.P.pshhssslshNTpP..Th.ccsh............EKPF......IhSIH.......DRNLYoGEE....YoYNl....sM........STNohs............D.shsssN..........................sl.......YSGIDLINDoL..Gsp.lDIYDElLKRKENE....LFGT.NHsKp.TSspSVAKpT.sSDPIhNQLsLFHKWLDRH...........RDMCEKW...NNKEElL-KLKEEWpp-sp........SuNh............................................................spN......................+sLNTDVSIQIcMDNPKPhNEF............oshDo.sptssMDoI..L-DLEK.aNEPYa...hpDD.IYYDVNs-cssosps...................................hspNs.hDV...PoKVpIEMcl.s..p..cllcEcYPIuDVWsI	........................................Tl.aululuhu.uhsahalK..KKs.KosV.sLhpllpIPKuDYsIPThhSsNRYIPYsSspY+GKpYIYhEGD....pusDp.tYh..schoDIT.SSESEYEEhDINDIYsPtuPKYKTLIEVVLEP.................................o.s...........c.T.p.NDI.sDsh.Pos.................phTDsEWNpLKc-F......ISphLQsp..ps.P..shhpssls.NTps..Th.hcs..............-EKPF......IhSIH.......DRsLYoGEE...hsYsh.............sNs.p...........................p..h.tpN....................................YSGIDLINDsL.sGs..hDIYDEhLKRKENE......LFGT.pasKp......To.psVuK.s.psDPIhN.QlpLhHp.WLD....RH...........RsMCEpa...pscp-hLsKLpEpWpp-sp.............ussh..................................................stN.........psLNTDVSIpIcMDpsKshpph............o.........sMDshhps.hc..................sD.IYaDVp.p.t..........................................spN..h-h...PpKlplEMpl.s.......t.hc.paPI..........................	0	22	22	22
+15301	PF15446	zf-PHD-like		PHD/FYVE-zinc-finger like domain	Wood V, Coggill P	pcc	Pfam-B_5236 (release 26.0)	Domain	This family appears to be a combination domain of several consecutive zinc-binding regions.	27.00	27.00	27.20	27.80	26.20	25.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.84	0.71	-11.46	0.71	-4.98	28	70	2012-10-03 17:27:21	2012-09-20 16:37:26	1	6	70	0	57	73	0	166.90	44	10.80	NEW	sCcoC...usstp+G..sLlaCQGCosSYHKsCLGsRSsR-HhVTKVGs-sFVLQCRhClGlh+cKDstAP+putCpsC+ppGhuCtPFpp+pTs+QEpplR--NuGsDPITsV-ssL..lNNs-NVLFRCs....pC+RuWHhcHLPshup.s.sssssps..........p.h..pppRhcEYShcWpC+-Ct	.................................CcsC...uss.p.+G..sLlaCQGCosuYHpsCLGsRusR-HLVTKVup...-pFVLQCRhClGhs+pKDspAP+putCptCpp.Gt..hscPh.Rp+hTs+QEpplR--NuGtDPITsV-.sL..lNN.....s-NV.....LFRCs....sC+RuWH.hcHLPshspss.t....t.p.p...........p.htppRhpEYohcWpCc-C..........................................	0	10	27	45
+15302	PF15447	NTS		N-terminal segments of PfEMP1	Rask T, Coggill P	pcc	Rask T, [1]	Domain	NTS, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors [1]. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1α1), shows this region is directly implicated in rosetting.  NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1α domain that is found to be the important heparin-binding site [2]. This family is closely associated with PFEMP, Pfam:PF03011, and Duffy_binding, Pfam:PF05424.	25.00	25.00	25.40	25.20	22.90	22.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.49	0.72	-3.56	205	318	2012-09-24 07:58:16	2012-09-20 17:12:31	1	36	2	2	14	324	0	37.30	39	3.36	NEW	sAKclLDpIGcpVa.cc.l+...p.........c.....A..cpY.ps.pLKGsLspApa	..SA+slL-pIGcplpcc.scp.........c....A....ppY.pspLKGsLopApF..	0	14	14	14
+15303	PF15448	NTS_2		N-terminal segments of P. falciparum erythrocyte membrane protein	Rask T, Coggill P	pcc	Rask T, [1]	Domain	NTS_2 is a family of the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) [1]. However, in this group of proteins conservation is high. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors.	25.00	25.00	29.60	98.10	22.50	17.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.60	0.72	-3.67	6	14	2012-09-20 16:26:11	2012-09-20 17:26:11	1	6	2	0	0	16	0	50.70	79	1.93	NEW	MDSKoTIAsKIEAYLccKSs-ScIDQSLKADPSEV-YYsSGGDG.YL+pNI	MDSKoTIA-KIEAYLttKSsDSKIDQSLKADPSEVpYYpSGGDG.YLKNNI	0	0	0	0
+15304	PF15449	Retinal		Retinal protein	Eberhardt RY	re3	Jackhmmer:A6NGG8	Family	This family of proteins is found in the photoreceptor cells of the retina [1,2]. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy [1-4]. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina [2-3].	27.00	27.00	60.30	40.20	17.70	26.80	hmmbuild  -o /dev/null HMM SEED	1287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.27	0.70	-14.14	0.70	-6.91	14	48	2012-09-21 07:43:49	2012-09-21 08:43:49	1	4	32	0	29	36	0	990.40	43	96.82	NEW	MGCTPSHSDIVNSVAKSGIQFhKKPKAILPG+QusSE+sSIPLLVpSSTCaDsGtshptG.......pc.tpEpPus+hsQosucuhpQhstsPhsuptKDhEGhhPEscoo.SQLscSQSHhAcDlsh+TQuSHtoQGuuFuG-EucEssoQcoSpht+KP+CHpsucQ.GHs..sQT....hhPAhtscuKVDFPEPLVKAHQ+AYsYLHosLSKYEAILplscQAoQTpELLQPMVoFLLLCF-ElNQLLGEISKDGEsLLQEV+tDLAWP.+KGEPpEQPDLLQQLLQYTVuKLQlLpGTVAoLTuShLEGSuSYLposASHL-sKLSsKRGhDE+LLRALGQLESLASGHuDPGlpshPLCSEDSGIGADNESVpsl...DKLGKQuSWDhssEPuEWKsshsP.psEA+hsGpuWQpuPahhGuDRPQDCPLSRPhtAKlQPAAQGpAsssssSuouPEssoo.RPhthuKSssp....-Shusssss-A+hsKu.StlhsoPSLSEsEDSSsE.E.-ED-huuhs.sshpcpss.sRPpSSPAssESsFQP+s+RLRSPQAQEMILKMKEAISERIKFVPVPSu+QDWAEE.EEt+ThVssRPSTsSGSRRAPtRQRRSQSEuCLKSasEDPTLQELRRVQ+DLSQRLEsFYALGs+pQGQu........pEplL.PRAAs.LhP-sssRVsPSoTISKLKASLTKNFSILPSQDKSILQ+ssPpP.......EuEps.Q...scAEtLPss...hPsuE+......s.EA......PGspDhssRGCPTRTSVKKLIETFSPsEuLRT.GDS+ssGsSPCLRKWGlPIMPPRFPIYRGLAPLYPKPQISPAuGp-sLphG.uWRPhAPhFPPL.sAEAscs-D..h..ssEs-ED.EcLPPPPLEILMDKSFsSLEsPESSpsuGSSsEsTtsPGLupssss.+RTWASPKLRASMSPhDLLPSKsssoPsRspuTGPGsoKsssssRKLsLDLsp...sPAsutsPEsEu...tu...Q..sp..A-+AsSLuKpPpKAlPWHHsSpTSGQs.RTpEPSlARPopGP.....+SPEAs......RpopERSPsllRKASPTRuH.WsPpuD+Rp.S.PSoHRP........AQPSlPsVpuSP....SPPl.........SP....Rs............hSPPss++hsSPPsp+KhPSPP...s.............huSPPsQ+sEAuSPuSuPSsSPPsSPSQGpK-sp...cS.EDupuusu+suuNTpSIFCPATSSLFEA+...sP.Sss+PhoP....PEuGGshtpPsGsWRuSuGPRhRu-SQRpsuLCALNPQPFlRRTASDRpP....Gs..+LpLP.usuhsupsspsthSpSSS.S.EESPKK-sEPWsuPsuPEL+G.uuRtASPPELCVLGHGLQ	.......................................MGCoPSHotIlpolA+sGlphh+KPKslhss.ttss-+hslPLLspsSohhs.st................ppt..t.ph..thtps...........ptcthpt..stsps...ph.cuQp+hscch.h+pQuSptoptsshss-pspEpsspt....t+p.+spppupQ.s+h...pT.....hss.tsctKVDFPEsLVKAHQpAYsYLHssLSKYEAILplhcQAoQTp.lLQsMloFLlLpF-ElspLLtEIucDGEhLLpEVttcLAWP.pKt-spEQ..............PDLLQQLLQYTVsKhQhLpuTVAsLTuohLEsSsuYLposAs+LppKLpsKRshDEpLL+sLupLEuhAsupucPthpshPLpSEDSGIGADNESlpth...DKLG+QsSaD.ssc...phc.hhts.phEst...psWppsPhhhu.tpspDs.Lpt..hshhpPtspststsss.S..shsstshss..shthtpStst....sShshshshcsch.cs.st.hsssShs-sEDSos-.E..--p.ushs.p..pcpt...RPpSSPAsh-usapsps+Rlcu.QApEMILKMK-AISE+IKFVPs.sspp-WsEE.E-tpshlssRPSTssG..up+sst+Q+RSpSEtsLpSpsEDPTL.ELpRlQ+DLSp+LEhFYshst.+tpsps........pcp.hpPRsss.lh.ss.spsssSsohS+LKASLoKNFSILPSQDKslhQ+sssps....csc...p.spAEtL.ss...hsssEh......pcsstspchsscuC.ss.RsSVKKLIETFSP..sEplth.tso+s.GsssClR+hGhslhPPRhPhYRGLAPLYPK.pIoPusutp..phs.uW+PhAPhFPPl.tuttscpp-..h..pt.Eh-t.s.EpLPPPPLElLMDpSFsSLEsPEospsstsSscts.t.Pu.spssss..++ThsSsKL+AShsPhDLLPSKssssss.t.pus.usGss+stspsRc.sL-lpp...sPssstssEhps...tt....sps-cAsuL.+pspKslshppsu..s..SGps.ps.Esuh...uRs...............+pupE+SPshsRKsSPoRsp.Wssps-+R..S.PusaR.........uQPS.sslpp..P....SPPh.........SP+s............hSPP.st+c.sSPPhp.KhPoPP....s............pp.sSPPsp+.EsusPsshso..PSPPhSPSps.Kpsp....co.--spss.uKsuuNspSIFCPAoSSLFEA+...ss.s.sp..ss....PEsGs..ttss.shRsS.tsh.hu-pQRphslsAhNP.PFlRRohSD+p.....t.t.t......t.....t....p.t.spssu..t.EEus.p-sts.hssspss-lpt.us+.su.P-hhVlGpGLQ.................................................................................................................................	0	1	6	14
+15305	PF15450	DUF4631		Domain of unknown function (DUF4631)	Eberhardt RY	re3	Jackhmmer:A6NI56	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 394 and 668 amino acids in length.	28.00	28.00	29.70	28.60	27.90	27.60	hmmbuild  -o /dev/null HMM SEED	532	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.85	0.70	-6.22	8	50	2012-09-21 08:26:51	2012-09-21 09:26:51	1	3	32	0	23	51	0	415.00	42	75.89	NEW	LsSosssPEQDTsKRWcQLEQWVA-LQAEVssLRGHKpRCE+AoLSLLRELLQVRA+lQlQsSELcpLppEl+.psAhsPEKEA.EhSGsQ..sQNQMQALDKRLVEVREALTQIRR+QALQDoERKGuEQEAsLRLs+LoshL+QEEQuREsACSuLQKsQE-uSQKVDcEVARMQAQlTKLGEEMSLRFLKREAKLCGFLQKSFLALEKRMKASEooRL+sEsuLREELEuRWppLQELsEERLRuLpGQpEVususp.QpEEu+LLEQCRGLDpAVVQLTKFVcQNQsSLNRVLhAEQKAR-AKspLEESpApELAuYlQENLEAsQLA......u-LApQETpssLELLQ.EKSQsLEsSVApLspQLKDLsDHhLALSWRLDLQEQTLuLRLoEs+s.EWEGsER+SLEcLAphpcEspAHL+EVpEKVD.uLPQQIEuVSDKClLHKSDSDlKIsAEG+AREaEVcslRQELAsLLSSVQLL+E-NPGRKIAEIQGKLA..TsQIhKLENSIQsNKTIQNLKFNTETKLRoEEhAoLRESh	.......................ppt...pQDs.pph.Q.pp.hspLps-lsplRtpppp..s-pthhtL.p-lhpl+sphphQso-Lhplpp-h...hs.s......-..st.....psthphLDpRLhEl+EtLsplp+p.s.pps-RctsppphshRLs+Lssh...LpQE-psREsACusLpKsQE-sup+ls.E...sA+hp.AplscLuEEhSL+FL+REAKLCuaLQKsFh.ALEpthKspEssR..hEtsLttELEs+WptlpthhE-+ltuLpuQp-..........tEcu+LlEQCpuLDtAVstLT+FVppNQsSLs+lLhAEtKAh-u+splEcopst-LsshlppslEAhphu......uc.ApQEhpspLplLp.EKspsLEsSl.spLsppl.+-Lss...+h.ALS.+...............lDLQEQhLsh+Ls-s............ps.Eapusc+csLcclsphpcEspscLctlpEKV-....ulPppIcslSsKCllhKsDsDh+IssEu+sRch-ltslRQELAslLpulQLL+EcsPu.....RK........IAEhQGcLs..ppQIhKLEsslQssKTlQNL+FNsEs+hRhp-hAsL+Eph...........	0	6	7	11
+15306	PF15451	DUF4632		Domain of unknown function (DUF4632)	Eberhardt RY	re3	Jackhmmer:A6NIN4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 59 and 190 amino acids in length.	27.00	27.00	126.50	126.40	24.00	18.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.45	0.72	-4.05	5	14	2012-09-21 10:53:32	2012-09-21 11:53:32	1	2	12	0	8	17	0	69.60	77	70.53	NEW	AGuPAKESGDsDGEAD.EEGESEKGAGPRSAGWRALRRLWDRVLuPARRWRRPLPSNVLYCPEIKDIAHMTR	hGsPAKESG-.DGEsD.-EtESEKGAGPRSAGWRALRRLWDRVLAPARRWRRPLPSNVLYCPEIKDIAHMTR	0	1	1	1
+15307	PF15452	NYAP_C		Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter	Coggill P	pcc	Jackhmmer:Q6ZVC0	Family	NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8 [1]. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice [2].	25.00	25.00	33.40	33.20	23.70	18.80	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.17	0.70	-5.42	3	80	2012-09-21 12:13:01	2012-09-21 13:13:01	1	6	35	0	40	66	0	245.10	47	38.50	NEW	LASPHSLPDPTusPL.sPLWTYPoT.AGLKRPPAYESLKAGGlLsKGCGVGAPuPMVKIQLQDQGTsGGAFASISCAHVIAS..SGTPEEE...EEEVGsuTFGAGWALQRKVLY.GRKsKDp.-TEssEGuRAWNGSuEGPSKsEREEK...GsLoSGIPVRSQGAEGLLARhHHuu+....GGSRTGLPlPCQTFPACHRNG.DFTGGYRLGRSASTSGVR..psslHTPRPCSQPR-ALSQsHPAL..sLPLPPQPu+ERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRGPEPRKSGTPPCRRQQTVLWDTAI	...............................tSPHuhP..cspuus..oPl.h.h.u.s.shuLKRPPsY-Sl+uGul.ppu...usPpshs+.plQ-tu.p...suAh.so.h..usupshup...utTPpp.....EE.hsuhFsuGhuL.RKs....GtRptc...h.-..cspDth+shstSs.Es.sKlEpc-R....Gs..su....St.P....V+....uQth-Gh.....tss............suSRhuhs.ss.Th.Asp+su.-.psuh.RLGRSASTSGV....su.l.p.s.R.sSps.p.s................................................................................................................................................	0	1	3	13
+15308	PF15453	Pilt		Protein incorporated later into Tight Junctions	Coggill P	pcc	Jackhmmer:Q5JTD0	Family	Pilt is a family of eukaryotic tight junction-proteins that binds to guanylate-kinase. Pilt is a component of TJs (Tight junctions) rather than AJs (Adhesin junctions). The protein is incorporated into TJs after TJ strands are formed, thereby suggesting the name Pilt for 'protein incorporated later into TJs'. Pilt binds to the guanylate-kinase region of hDlg otherwise known as Disk large homologue [1].	27.00	27.00	27.00	27.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.36	0.70	-4.74	15	99	2012-09-21 13:25:27	2012-09-21 14:25:27	1	3	38	0	48	81	0	224.40	47	54.09	NEW	Moss..ss..........sus..tstpsspQ.pNGpCpSpuoh-uss..E-.hslPuFEKLNPYPTPsPPHPLYPGRKVIEFS.-DKV+IPKNSPLPNCTYATRQAISLSLVQs--..c+.s.........+s.ussPs.......o..P..uSs......s..........uSsQssP.S...............................s.PQ.sPSshASSuSSEEDL.LAsWQRMFVEKssPou-tull.pRTuFS+-TAtELQ++h.sh...us..ushspsssAa...........................................................us..u.-Eus.pll.........sttssstps+-c...p-lslPsSspEE..+..p.LLptpcttppsss.stp..scs....................stssSuRPQRSPKRMGVHHLHRKDSLTpAQEQGsLL	......................................................................................................................................st...........us..hstpst.Q..NGpCps.uostuss..E-..shPuF..EKLsPYPTPsPPHPLYPGR+VIEFS.-DKV+IP+NSPLPNCTYATRQAISLSLVppss..cp.t.........p..sssss.............s..s..tus..................tuspppP.s......................................s.s..h.Ss.ASS.uSSEEDL.LusWQRhFV-+hsPsu....s..h..spRTuFuccshs-L..Q++h...sh....us....sshst.h.s........................................................................h..............s......ptt.............th.ls.Sst-p..pp.l...t...t.h...t.....t..............shss.pRPp+SPKRMGVHHLHRKDSLTpAQ..GsLL.................................	0	1	7	18
+15309	PF15454	LAMTOR		Late endosomal/lysosomal adaptor and MAPK and MTOR activator	Coggill P	pcc	Jackhmmer:Q02205	Family	LAMTOR is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes. It is found to be one of three small proteins constituting the Rag complex or Ragulator that interact with each other, localise to endosomes and lysosomes, and play positive roles in the MAPK pathway. The complex does this by interacting with the Rag GTPases, recruiting them to lysosomes, and bringing about mTORC1 activation.	25.00	25.00	25.20	25.50	24.20	24.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.53	0.72	-3.69	45	181	2012-09-21 14:43:52	2012-09-21 15:43:52	1	2	170	0	125	166	0	75.80	28	44.32	NEW	psEpo+LLscs...ps...shstht....st.s........pssspphp.Rc.pAL.ssIlpcTu-slIDlsuhpsps...ht..ppp.hs.s.phhst	...............sEpp+LLt-s.....ps..s.stht..pssp.s...........pppspphp..cE.pAL.psIltcTusslIDlsuhsspsh...tpp.h...p....s...........	1	25	52	91
+15310	PF15455	Pro-rich_19		Proline-rich 19	Eberhardt RY	re3	Jackhmmer:A6NJB7	Family	This family includes proline-rich protein 19.	27.00	27.00	40.10	40.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.14	0.70	-5.42	8	30	2012-09-21 15:10:35	2012-09-21 16:10:35	1	2	24	\N	15	29	0	307.60	61	73.26	NEW	MDPRGPAPQPFQQPEKPGRVRRRKTRRERNcALV.......GSRRPLA+Q-PPVASRDP......P......VuPsAPKLVVITQGRLSREHRGLFNHEVKSLDVARLLSSGoLEPsTPsLsTKPSPSPGRuQEPu...QSRGKENQVPGGSGPGPPSsPELPGlGQLLpELQCQLlLPQAFPRRNLVQEARDAIVGTLQACHGCVPDLuLVLRGCQPPLP..GsKPpssERpRMTPSWINSPEQ..APtEGRQRRp..QGTKElTFsMPHT.SSTPTsHRsSLsPP+GPW.....PPsLPSLsSPSGsAWGPPTAFDLLKSIWLVATPP...PP+PWGVGPPQPLPQPPSPLLPRTSALDWSPSPPAPLPSLSWVVAQSSPEAWSFPPMRLY	.........MDspGPssQPFQpPEKPGRVRRRKTRRERNcALs.................GSRRPLs+pDPslupRDP.............P......VsP..sAsKLVVITQGRLSREHRGLFNHEVKSLDVARLLSutsLpPsoPsLPsKPSPS.......PuRuQEPu...QSRuKE....NQVPGGSGPGPPSs..P-LPulGQLLtELQCQL.LPQAFPRRNLVQEARDAIVtTLQACHGCVPDLuLVLRGCQPPLP..GsKPtssER.+MTP.WINsP-Q..sPtptRQR+p..pGTKEhsFshPaT.SShPssHRsSlsPP+uPW.....PP.hs.hsSPSGsAWGPPTAFDLLKSIWLVATPP...PPpPWslG.sQPLPpPsSPLLPRTSsLDWSPsPPAPLPSLSWVVAQSSPEAWSFPPMRLY..................	0	1	2	2
+15311	PF15456	Uds1		Up-regulated During Septation	Coggill P	pcc	Jackhmmer:Q9P6S3	Family	Uds1 is a domain family is found mostly in fungi, and is typically between 120 and 138 amino acids in length. The GO annotation for the S.pombe protein describes the protein as barrier septum assembly involved in cell cycle cytokinesis, GO:0071937. Many of the uncharacterised members are listed as being involucrin repeat proteins, but this can not be substantiated.	27.00	27.00	27.00	33.30	26.90	24.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.42	0.71	-4.13	55	148	2012-09-21 15:33:05	2012-09-21 16:33:05	1	4	90	0	122	149	0	126.70	34	15.67	NEW	tlcLLscsAlsDSppaElLohEEV-sLKKEhphLspRlcss+cpLs.lcsKhR-.AAtS..ls+Lhsstptt.......................t.sppshpcs-cpLstss++s-Ehsp-LhplEpRhtclcp+LLEHsAulLphop+	............hcLLpcpAhs-upcaElLshEEV-sL+......+.....Ehph..............LspRl-hh+cphs.lctchRc.usts.lsphhpssptt.............................................sphspcshhcpEEtLup.-pph-EhspcL.phEpRttcl+p+LLEHsAulLphs........	0	32	66	100
+15312	PF15457	HopW1-1		Type III T3SS secreted effector HopW1-1/HopPmaA	Coggill P	pcc	Jackhmmer:Q8RP17	Family	HopW1-1 is a family of bacterial modular P. syringae Avr effectors that induce accumulation of the signal molecule salicylic acid (SA) and the transcripts of HWI1 (HOPW1-1-INDUCED GENE1) in Arabidopsis. Thus HopW1-1 elicits a resistance response in Arabidopsis [1].	27.00	27.00	64.80	64.70	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.11	0.70	-5.39	5	28	2012-09-21 15:54:11	2012-09-21 16:54:11	1	1	20	0	1	31	0	288.10	65	38.93	NEW	MMPSQITRSSHSSLP-sSPASuDAsSSpEQSPQQsRT+AFVASGELusAFGRTSTAPAQDsVRLLusLQREL-KcsPSaP-VApLuppLAEAAMTEQGhHhLAoEE.Q.psLKslLDRCT+QLADTPAScASHDuLSQACEGLKTARLHQSlApLTGcoHApsRGVPDLLALsHLDP-VLA-KPsuhsSYspFGSFIpTAKsRTA-Ls-SLpcsuuEVsuLLRuHADTLpuLE+LPuALAALTENCPDsPTpcDLRuLAEsAGELLQQLRssDLLPRSEEISSEsGEosV+u+EsVE...P+LTpuQALLhAGGNLVRKFDAYGAl	.MMPuQITRSSHSSlP-susASuDAsuspEQoPQQsRThAFhASGELusAFGRTSsAPtQDsV+LLusLQREL-KppPSa.sVApLsppLAEsupTEQGhH.LAoE-.Q....sL+-lLDRCpppLADhPAucASHDsLSQACEGL+TARLHQSlApLTucspuhsRulsDLLsLsHLDP-sLutcPsshoSYshFupFlpTAKpRTA-Ls-sLpcpPstVsuLLRuHADTLp-LEhLPuALtALTENC.DsPsps-LRpLAEsAGuLLQhLREpDLLPR.EEIS.EsGEuPs.u+EssE...P+LTppQALLKsGGNLVRKFDAYGAl......	0	0	0	0
+15313	PF15458	NTR2		Nineteen complex-related protein 2	Coggill P	pcc	Jackhmmer:P36118	Family	NTR2 or Nineteen complex-related protein 2 is a family of largely fungal and plant proteins that form a complex with the DExD/H-box RNA helicase Prp43. Along with NTR1 it is an accessory factor of Prp43 in catalysing spliceosome disassembly.  Disassembly of the spliceosome after completion of the splicing reaction is necessary for recycling of splicing factors to promote efficient splicing [1]. NTR2 and NTR1 associate with a post-splicing complex containing the excised intron and the spliceosomal U2, U5, and U6 snRNAs, that supports a link with a late stage in the pre-mRNA splicing process [2].	27.00	27.00	27.80	28.00	26.30	26.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.71	0.70	-5.14	41	137	2012-09-24 10:30:19	2012-09-24 11:30:19	1	6	131	0	107	140	0	244.70	26	44.95	NEW	spYsp-YlsELpsuTsss.P..............tp-tp...........hsl-shph.st.h.................spsstIPocuEIcEtKpRRsRL...spcp...............pc.alSLpD....p-ctth..............cpppt-oRLsc-D--h..sEGh--asp....Ds+luL.G++sc+pppp++RcphpEhIps...........p-s-sEcpts..aEssQh+tGhsshp.................th.p.s..................PphssLP...pLsssl........p+Lppsl...sshptpppphppplppLpcE+tcIspRcp-lpphlpc	...................................................YspcYlpELpsso.ss..Ppt......................ts.p......................hpl-..t....th.sthh..................spsssIPocucIcctKpRRs+h.........tpcp..................tc.aIuLp-......tsp.pph............t.cppptcoRLlp-D--h..sEG.h--asp....DspluL.Gc+sc+cpcc+...+Rppht-hIsc..................ttts-s-sEcptt....aEssQhRtGhsshp.................................t...t..p.s...................................sphssLP...pLsssl.............t+Lpptl...sthctppsphttplpp.LccE+t-lttcct-lpthlp..........................................................................................................................	0	34	59	89
+15314	PF15459	RRP14		60S ribosome biogenesis protein Rrp14	Wood V, Coggill P	pcc	Pfam-B_10508 (release 26.0)	Family	RRP14 is a family of nucleolar 60S ribosomal biogenesis proteins from eukaryotes. RRP14 functions in ribosome synthesis as it is required for the maturation of both small and large subunit rRNAs and it helps to prevent premature cleavage of the pre-rRNA at site C2 [1]. It also plays a role in cell polarity and/or spindle positioning 2],	22.40	22.40	23.20	23.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.32	0.72	-3.90	54	167	2012-09-24 12:25:37	2012-09-24 13:25:37	1	6	153	0	128	164	0	56.80	45	11.77	NEW	c-cL+pHuptFDsLlsLIPAKaYhs.-csp.............cphKp..KKpo...KcptKpA...K+sKLDP-	...p-RL+sHupuFDuLLuLIPAKaYas.--ss................cQh+p......KKpT...K-ps+pA...KRuKLDP-....	0	43	79	112
+15315	PF15460	SAS4		Something about silencing, SAS, complex subunit 4	Coggill P	pcc	Jackhmmer:Q04003	Family	SAS4 is a family of largely fungal silencing regulators. This silencing is mediated by chromatin. SAS4 specifically silences the yeast mating-type genes HML and HMR [1]. SAS4 is found to be one subunit of a complex, the SAS complex, that interacts with chromatin assembly factor Asf1p, and asf1 mutants show silencing defects similar to mutants in the SAS complex. Thus, ASF1-dependent chromatin-assembly may mediate the role of the SAS complex in silencing [2]. Co-expression of Sas2, SAS4, and Sas5 in Escherichia coli leads to formation of a stable SAS complex that acetylates histones. SAS4 is essential for the acetyltransferase activity of Sas2, and Sas5 is also important [3].	22.50	22.50	22.90	23.20	20.90	22.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.33	0.72	-4.14	48	116	2012-09-24 12:56:10	2012-09-24 13:56:10	1	1	114	0	88	119	0	97.90	40	18.86	NEW	DPLsDshYpshH++hcRpE+phpNt-+tRuppEt-pLpclL-tLpsh.............DWlRsh.slTs.Is-.s-cc-hEsKRphhlcplpslLcKFcpW+ccccchp.tcpc	........DPLsDshY.hhH++hERpE+plRNtE+tRupaEp-pLp+LL-pLpuh.............DWLRlh.Glou..ls-..s-++phEsKRphh.......lctlpulLcKFctW+ccE++p+hc..c..............	0	15	43	73
+15316	PF15461	BCD		Beta-carotene 15,15'-dioxygenase	Coggill P	pcc	Jackhmmer:Q4PNI0	Family	BCD is a family of bacterial and archaeal proteins is found in bacteria and archaea that catalyse or regulate the conversion of beta-carotene to retinal [1]. Characterisation of BCD proteins shows them to cleave beta-carotene at its central double bond (15,15′) to yield two molecules of all-trans-retinal. However, the oxygen atom of retinal originated not from water but from molecular oxygen, suggesting that the enzyme was a beta-carotene 15,15′-dioxygenase, rather than a mono-oxygenase that catalyzes the same biochemical reaction [2,3].	27.70	27.70	54.90	54.90	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.98	0.70	-4.97	56	106	2012-09-24 13:25:51	2012-09-24 14:25:51	1	1	93	0	33	115	1588	261.10	23	85.69	NEW	llullhlGlPHGAhDthlsh+h.h.........phpthhtahshYlslushhlhlWhhhPshuLhlFlhlohhHFGpuDhtth...........ssh...chh..th..........ls+GGhlhhhls.hh.ph.....sc........shtlh.shl.ss......ss.tsh..............shp.......s.....lhh.hhhh....hh.luh.h...h......hh...htthp........tc.tht.h.....hsEhs...hLhhh.FhhlPPlluFulYFslhHShRHltchh................ppl....st.ts...st.t...........h.............hhp.puhsh...olsuhlh..hs...slhh..hhss...shsh......tss...h....lthhhlhlAuLTlPHhlllshhc+c	.................................lullhlGlPHGAhDhhlsh+h.h..........php.hhhahshYlslsshhlhhWhhtPshuLhlFlhlohhHFGpsDhthh...........sph..phh.h...ls+Guhhlhhss.hh.phsp........shtlh.shlss.......ss..sh..............hht..h....hhhhhhh....shlsh.h...h..hh...htt.ht........tptht.h....hs-hhlLhhhhhhlPPlluFulYFslhHSh+phhphh................ttl.....pt.tt....ht.............h...hhtpshsh...shhuhhh..hs...shhh..hhss...s.........tst...h....lthhhlhlAuLTlPHhllsshh...................	0	12	25	29
+15317	PF15462	Barttin		Bartter syndrome, infantile, with sensorineural deafness (Barttin)	Coggill P	pcc	Jackhmmer:Q8WZ55	Family	Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.	27.00	27.00	47.90	46.70	18.70	17.30	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.71	0.70	-4.69	11	35	2012-09-24 13:54:09	2012-09-24 14:54:09	1	1	25	0	16	28	0	204.70	63	69.83	NEW	SHDRPQVYGTFYAMGuVMVIGGVIWSMCQCYPKITFVPADSDFQGlLSP..KALGLLENGLusEhK...u..PQPPYVRLWEEAAYDQSLPDFSHIQMKVhGYSEDPRPLLAPc.up...p.tuuDGGcG.uPp-uQAWlEAAVVV......HRGSDEcEGcRss.oQSpsuPPssPQGP...APLASFQDDLDhGSSEGSSPsPSPPstEEPpsPs.tEP..hAsRs.LDRFcDFALID.uP.TsED	...SHDRPQVYGTFYAMGulMVIGGlIWSMCQCYPKITFVPADSDFQGILSP..KAhGLLENGLusEhK..S..uPQPPYVRLWEEAAYDQSLPDFSHIQMKVMuYSEDPRsLLAP-huQ...chGsSDGGEG.GPtDsQAWhEAAVVl......HRGSDEsEGERph.oQShPuP.u..CPQGP...APLASFQDDLDhuSSEGSSPssSP.-tEEspsPp.pEP...uCRs.LDRFpDFALID.APThED...................................	0	1	2	4
+15318	PF15463	ECM11		Extracellular mutant protein 11	Coggill P	pcc	Jackhmmer:Q04110	Family	ECM11 is a family of largely fungal proteins. ECM11 interacts with Cdc6, an essential protein involved in the initiation of DNA replication, and is a nuclear protein involved in maintaining chromatin structure [1]. It was previously identified as a protein involved in yeast cell wall biogenesis and organisation, but is also found to be required in meiosis where its function is related to DNA replication and crossing-over [2].	25.00	25.00	26.20	25.50	22.80	22.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.47	0.71	-3.89	53	98	2012-09-24 14:36:33	2012-09-24 15:36:33	1	3	98	0	76	99	0	135.80	26	27.89	NEW	DYssptLpphsas-LpspsFD..hsPssht...............................ttsssss...shpp.+....lpphhpt..sppp...pc....phFushohc-W--sGDhhl-pFspllp+lpcsRpp+RchhphFEsEIscRpcsVptcsptlscKLpch+ptGpcll	......................................................................................................DYssthL.phsas-LpspsFD..hsPssst..........................t..ss......slp-.+....lpphhsh....scpp...pc..........paFusholsEW--sGDhhl-pFsplhp+h+csRpp+RphsthFEsEIpcRt-sVctcspt...lsc+Lcch+ptGtcll...	0	12	36	63
+15319	PF15464	DUF4633		Domain of unknown function (DUF4633)	Eberhardt RY	re3	Jackhmmer:A6NJI1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 123 amino acids in length.	27.00	27.00	69.70	69.50	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.52	0.71	-4.24	6	20	2012-09-24 14:54:23	2012-09-24 15:54:23	1	1	18	0	12	20	0	109.70	68	95.26	NEW	MGTuLRSQSLRGPpPSYGKLQEPWGRPh.....EGRLRRALSLRpGREKSRSp..-.tGPEtLDssGQEhLPGoLGDTEQLIQuQp.usSRRWLRQYQQpVRRRWcS.FVuSFPsVTLSpPAS	MGTGLRSQSLRGPRPSYGKLQEPWGRP......EGpLRRALSLRQGREKSRSQsL-...tGsEGLDssuQEtLPGoLGDTEQLIQAQR.uGSRRWLRQYQQpVRRRWcS.FVu.FPSVTLSQsAS	0	1	1	2
+15320	PF15465	DUF4634		Domain of unknown function (DUF4634)	Coggill P	pcc	Jackhmmer:Q8WWF1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 98 and 133 amino acids in length.	27.00	27.00	33.40	48.00	18.80	17.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.76	0.71	-3.94	9	32	2012-09-24 15:04:50	2012-09-24 16:04:50	1	2	22	0	14	26	0	117.90	64	98.13	NEW	MDVLFlAILAVPLILGQEYEDEEtLEED-YYQVsY.YYTVTPoYDD..FusNFTlDYShFESEDRL.N+.LDK-V..TEAVETTI...SLpTcttD+p+PVTlKPVThE.P...........SPDLNDA.VSoLpSPlPLLLShsLVQuGMY	.MDVLFVAILAVPLILGQEYEDEEtLtE.D-YYQVlY.YYTVTPsY.DD..FuusFTlDYShFESEDRL.N+.LDK-l..TEAsETTI...SLcTttsD+.KPVTlKPsThE.P.............SPDhNcA.VSuLpSPlsLLL.hshlQsGha.................................................................	0	1	1	1
+15322	PF15466	DUF4635		Domain of unknown function (DUF4635)	Eberhardt RY	re3	Jackhmmer:A6NLE4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 120 and 154 amino acids in length. There are two conserved sequence motifs: LEQ and DLE.	27.00	27.00	110.20	110.00	22.10	21.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.78	0.71	-4.88	6	26	2012-09-24 15:10:22	2012-09-24 16:10:22	1	1	19	0	12	15	0	130.80	70	94.84	NEW	MslQ......cVGsRtRsuA..........E.....lhERRccS.+C-.....DKKQoLLuLLILVLYLGTGI..SG+SWEVSERIRECNYaQNsVsSQGhEYQTsEPuEEPlKslRpWLKENLHVFLEKLEcEVRELEQLV+DLE.WLDALLGDsahEEPCS	.........MshQQVuuRtpVAA...............E.....LlEpRRsS.HC-.....D+KQTLLALLILVLYLuTGI..SGSSWEVSERIRECNYaQN.VsSQGhEYQTsEPSEEPIKslRsWLKENLHVFLEKLEcEVpELEQLVpDLEhWLDALLGE..s+.EE.Cu..	0	1	1	1
+15323	PF15467	SGIII		Secretogranin-3	Coggill P	pcc	Jackhmmer:Q8WXD2	Family	Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed.  These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells [1]. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells [2]. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion [3].	27.00	27.00	60.80	60.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.79	0.70	-5.40	8	53	2012-09-24 15:34:09	2012-09-24 16:34:09	1	2	36	0	27	59	0	404.80	72	96.68	NEW	plpAFPsPsuu.cDKulYNRELoEERPLpEQIAEADolKt....ucopsttspp-pcN.pDsDDLslLKSLAEppK.sKcsuslpsoh.-cphssDDoDSTKsRRLsDDYDSTKsGhDY.KYQDDP-uhRQLDGTPLTAEDIVQKIAs+IYEEsDRGVFD+IVSKLLpLGLITESQAcTLE.EVAEALQcLITKpAKNNEh-stshsttss+u-p......................ssscpscp+h..........h..ts.p........--o......susoWs..pshEcRNElsPEDshpDLQYFPNFY+LLKSLsS.EpDscE+ETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIAlQTKNKLGKuLu...ssshssPs-..Ksh-EsDsTKsEAAKMpKEYEsLKDSTK-E.Qsso-.s-cP.GKSEoYLEAIRKNIEWLKKHNK-GNKE..DYDLSKL+DFhDQQsDuYl-KGIL-KEEuDsIKRIYSSL	..........lpAFPpPsuu.pDKslHNRELSsERPLpEQIAEAEuDKh....+cshssENKsuppNYSFlDsLNLLKAlsEKEK.EKE+pSlRSSsh-s+Lsl-DsDSTKNR+LlDDYDSTKSGLDa.KaQDDPDGLHQLDGTPLTAEDIVpKIAsRIYEENDRGVFDKIVSKLLNLGLITESQAaTLEDEVAEsLQcLIoKEApNhEc-....scPsS+oEs........................psschsEc.h.....TshAuhQ.DuhspsEND-T..lSNThTLoNsLERRscsasEDsFE-LQYFPNFYALLKSIDS.EKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLD-MIALQTKNKLEKNsTp..hS+LFsuPoE..KSpEEoDSTKEEAAKMEKEYsoLKDSTK--psssus.T-EPKGKTEAYLEAIRKNIEWLKKHsKKGNKE..DYDLSKMRDFINQQADAYVEKGILDKEEA-sIKRIYSSL......	0	1	3	11
+15324	PF15468	DUF4636		Domain of unknown function (DUF4636)	Coggill P	pcc	Jackhmmer:Q8WWF3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 196 and 244 amino acids in length.	27.00	27.00	59.00	58.60	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.47	0.70	-4.91	8	36	2012-09-24 15:38:09	2012-09-24 16:38:09	1	1	27	0	19	25	0	224.10	63	98.88	NEW	MG-LhSLFWEVDPPPlPLoaoIPsQDaECpKDDSCGAIGSFLLWYFlIILVLMFhSRASVWMS.EpKcDEDSGTSASVSKASKDsSYKRQsK-GsWDSsQhM..KKPKQsQLoPVTDSEVALVNAYLEQRRAp+HSQhsQVNQlppDSDTTEsDSEESNSGASSWKESESEHHPSPAuI+RRKlAQRQ+slGSYQIRERPCLHCKAMRTNEWLTRHFLQssSsssPhKuDhQEENSlPEINTKFSK	....................MGcLaSLFWEhDPPshPLshsIPsQ-aECt..KDD..SCGslGsFLLWYFlIlhV...LMahsRASlWMS.EsK+...DEc..SGT.SsSluKASK-sShKcQSK-u.sWDs.QhM...K.KPKQsQLoPV..TDSEVALVNAYLEQRRAR+pSQFspVNQsQ+DSDTTECDSEESNStASSWKESESEHHPSPsSIKRRKhAQRQRNl.GSYQlRERPCLHCKAMRTNEWLsRHFhQpsSlssPMKG.D.QEEsShs-.INTKFSK.....	0	1	1	4
+15325	PF15469	Sec5		Exocyst complex component Sec5	Wood V, Coggill P	pcc	Pfam-B_353125 (release 26.0)	Family	This Sec5 family of eukaryotic proteins conserved is not representing the Sec5-Ral binding site.	30.00	30.00	30.60	30.70	29.40	29.80	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.89	0.71	-4.55	80	361	2012-10-03 17:31:52	2012-09-24 17:03:10	1	14	260	0	261	467	2	197.60	24	22.04	NEW	scplcpLlcsNFspalpsKsslDslapph..............pp...pptp.ttpt..........................................shppLpppl.pp...stppusphhpslLcppp+scphRsslshlp+h+hlFsLP...pplccs..lpc.s-Ycthlp-Y.......p+u+slhppp.................................psplhc+.....las-VEphh..pph+pplhppLhsss....................pshcp............hpphI.chLlcL........ps..........pt............cPhhhhlssp	...................................p.tthphlVcsNaspFlpspsolcslhpch............................................ct......ptpp....tt........................................................................hsppLpsslpp...ssspupplapslLsp+p+t-pl+sslshlp+h+hl...FsLP...sslpcs..Ipp.t-Y-tslp-Y...............p+A+slhtps..................................pl.lhp+..............................hhp-VEphl.....pph+c..pLhc+Lhpss.................................pshcp......................ttchl..phLhcL....................ps......ps................sPhW.hl..................................................................................	0	99	153	221
+15326	PF15470	DUF4637		Domain of unknown function (DUF4637)	Coggill P	pcc	Jackhmmer:Q8WW18	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 142 and 178 amino acids in length.	27.00	27.00	43.00	42.30	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.32	0.71	-4.64	5	25	2012-09-24 16:10:32	2012-09-24 17:10:32	1	1	22	0	13	24	0	151.70	67	90.85	NEW	MDKHGVKTPLWKKElEEPRAcEsEtEEAcEGSE-EDEsppRPPEESAAEGEt-uR.AEtsEGRERRSVSYSPLRQESSTQQVALLRRADSGFWGWLSPFALLGGLAAPADRKRSLPEEPCVLETRRRPPRRGGCARCEILFCKKC+oLHSHPAYVAHCILEHPDLGKAsAuGu	................MDK+..GVKTPLWKKEsEEscAcEsEtE..c..tcEGS....E.-c-p..pRsstESAsEGE..E.s.R.A-EsEGRERtSVSYsPLRQESSTQQVALLRRADSGFWGWLuPhALLGGLsAPsDRKRShPEEPCVLEhRRcPPRcGGCA+CEILFCKKCRoLHSHPAYVAHClL-HPDLG+AtAuGu.....	0	1	1	2
+15327	PF15471	TMEM171		Transmembrane protein family 171	Coggill P	pcc	Jackhmmer:Q8WVE6	Family	This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.	25.00	25.00	25.20	172.40	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.04	0.70	-5.64	10	40	2012-09-24 16:12:44	2012-09-24 17:12:44	1	1	32	0	22	37	0	297.50	63	97.65	NEW	SPsAAAEPDG-ppDRpVSKLIFFLFVFGAVLLCVGVLLSIFGFQACQYEsLsDCShVLKlAGPuCAVlGLGsVILARSRARLQl+ptphQGpQsDPDpAFlCGESRQFAQhLIFGFLFLTSGMLISILGIWVPGCuSsWsQEPLN-TDouDuEPQICGFLSLQIMGPLIVLVGLCFFVVAHVKKRNNLNsuQDASEsEEtpoQSsEPVQVTVGDAVIIFPPPPPPYFsEoSASAso.pSPGANuLLPsENPPSYYSIFsaG.RT..P-..sQGssSERDpESIYTISGTssSSEISHsPHLsSE.PPRYEEKETssuTsLSsSS	..........SssusAEPDG-ppDR+lSKLIFFLFVFGAlLLCVGlLLSIFGaQACQYcslscCuhVLKlAGPuCAVlGLGAVILARSRA+LQLRptphp.GpQhDsDpuFlCGESRQFAQCLIFGFLFLTSGMLISlLGIWVPGCuSsWs.Q-sLNETDou-uEPphCGFLSLQIMGPLIVLlGLCFFVVAHVKKRsNLNsuQDu.SEpEEtpsQosEPVQVTVGDuVIIFPPPPPPYFsESSuSA.ls.pSPGuNuLhPsENPPSYaSIFNaGpT.hP-sQGsAoERDpEoIYTISGssSSSEhStss+LsSELPPRYEEKEsssss.Ls.SS.....	0	1	2	7
+15328	PF15472	DUF4638		Domain of unknown function (DUF4638)	Coggill P	pcc	Jackhmmer:Q8WTQ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 240 and 272 amino acids in length.	27.00	27.00	41.20	41.20	22.40	21.80	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.02	0.70	-4.80	7	31	2012-09-25 09:50:52	2012-09-25 10:50:52	1	1	25	0	16	34	0	224.40	51	86.44	NEW	MoEps.DhcsLMPTERKShWRTAEERRMSDLTRVLEWLERRQGKK+Qs.p+pKpcsps...ss.tKtpKKspGhpc.tpttsp+ss.hspphlp.ht...+cs..ssth++h.ts-.KG+RLShlsusYs+Dus+K....S............DlDIKDsIALES.sQRsssaRRQSo.lDPhlQEs.hFGsRRuolLR-W.osKsPDssYERKLKSLMEKGhEPKhEhsKMLKPEEVLSCRYLRLSKNNIRTLLKLCKDAGMsVDIHPHMVEuEIDAKKVFupp.SVA	..............................MoEps.sh+slMPTcRK.hW+TsE-RRMSDLTRVLEWLERRQGKKKQs.pK.pKscshs......ctp.tKctKKspGhhptp......ttsp+.........ts.hs...p....psht.......++s...ssta++h.sl-.KG+RL..Shl.s.usY.h+Dus+K....S............-hDIKDsls.ES.TQRsssaRRQSh.lDPhLQ-...s.hFuuRRsohhRDW.ssKhPD.sYERKLKSLMEKusEPKhEsh+MLKPEEVLSCRYLRLSKpNI+TLlKLC+DAGhsVDIHPHM.lEt-IDs+KlFst..shA........................	0	3	3	4
+15329	PF15473	PCNP		PEST, proteolytic signal-containing nuclear protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8WW12	Family	PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation [1].	27.00	27.00	28.30	31.90	26.70	26.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.99	0.71	-3.90	11	113	2012-09-25 12:41:17	2012-09-25 13:41:17	1	5	66	0	63	106	0	125.80	61	77.26	NEW	GPEEcuEcsh+p+slSS.........osGGcuSS..RSuE+tust..............-tspsssssPsPsKlSKhGFuh..............sothh+Ks..ssISIKLGAo.....KEss..lss.p.slAuVFNtD.DDSEPEEMPPEAKMRMKNIGR-TPTSAGPNSFsKsKaGFsDspKlaERclK	.....................................................................pEtttp.hppphssS............ssuGEuoS..+SuE+pusp...........--stshssc..PsKhSKhGFu...l................uoQ...ssKKu....suISIKLGus...KPKEss......PolsPK...phoVAusF..NED...-DSEPEEMPPEAKMRMKNIG....R...DTPTSAGPNSFNKGK+GFSDsQKLWERslK..............	0	16	20	37
+15330	PF15474	MU117		Meiotically up-regulated gene family	Coggill P	pcc	Jackhmmer:Q9Y7V0	Family	This protein was identified as being up-regulated during meiosis in S.pombe.  This family of proteins is found in largely in plants and fungi. Proteins in this family are typically between 128 and 920 amino acids in length.	27.00	27.00	32.10	31.30	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.18	0.72	-10.87	0.72	-3.50	16	50	2012-09-25 12:57:57	2012-09-25 13:57:57	1	5	20	0	46	50	0	101.90	29	25.76	NEW	shsCKGSulCus........ts......ssuCssAlspa..psssl............Y..............pshsu.............hspus.....ChA............hapCss..s.ss........uho......Gpplhsthpsl...csssCptCGohtass.....pCplslsYCo.sC	....s.hsCcGSuhCus.........st.....tssCcpAlsp.h...ssssh............Y.......sshou...........................hssGp.....Chs............hapssG..s.ss........slo........Gsplhssappl...cspsC.p.hCGstta..ss.....uCphslsYss.sC..............	0	11	31	44
+15331	PF15475	UPF0444		Transmembrane protein C12orf23, UPF0444	Coggill P	pcc	Jackhmmer:Q8WUH6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 119 amino acids in length.	27.60	27.60	27.70	71.40	25.50	27.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-3.93	8	68	2012-09-25 12:37:30	2012-09-25 14:34:08	1	1	40	0	44	43	0	91.50	75	79.89	NEW	sKDHPpsps....GMlWRVTGGLFuVTKGAVGATVG....GVsWlGGKSLElT.KTAVTo...VPuMGVGLVKGGVSAVAGGVouVGSuVAuK.VPhT.uKKKDKo	............KDHPQQ.QP....GMLSRVTGGlFSVTKGAVGATlG....GVAWIGGKSLElT.KTAVTo...VPSMGlGLVKGGVSAVAGGVoAVGSAVssK.VPhT.GKKKDKS....	0	2	8	23
+15332	PF15476	SAP25		Histone deacetylase complex subunit SAP25	Coggill P	pcc	Jackhmmer:Q8TEE9	Family	SAP25 is a family of proteins found in eukaryotes. SAP25 is a core component of the mSin3 co-repressor complex whose subcellular location is regulated by PML. mSin3, the transcriptional co-repressor, is associated with histone deacetylases (HDACs) and is utilised by many DNA-binding transcriptional repressors. SAP25 is a nucleo-cytoplasmic shuttling protein that is actively exported from the nucleus by a CRM1-dependent mechanism. It binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA [1,2].	27.00	27.00	155.10	155.00	19.80	14.90	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.49	0.71	-4.81	5	25	2012-09-25 13:48:04	2012-09-25 14:48:04	1	1	22	1	14	27	0	186.90	67	79.86	NEW	MTLLAPWDPNYEAKAGPQLVWGPSCGSGASFSGRTLCHPSFWPLYEAuSGRGhRPps...PuuGHQsGEQAPRDAGFPVMCsEDVFLLDPLLPsGQRVPLYLSEAPQQVMGSLKLLLPPPIMSPpVhPhPSpspGCSTAWLSGPELIALTGLLQMSQGEPRPuSSGuP..ussussPussS-sPusS...GGP.SCSHuTDPSLPpTPDTHCP	MT.LAPWDPpYcAKAGPR.VWGsuCuSGASFSGRTLCHPSFWPLYEAASGRuLRPhs...PuTGH.NGpQAPtDAGFPVMCsEDVFLSDPLLPpGQRVPLYLSEAPQQVMGSLKLLLPPPIMSPhVLPp.SsspGsSTAWLSGPELIALTGLLQMSQGEPRPuSS..uus..ss.sGsPsssS-.PuPs...Gus.SsSpssDsSlPtTPDsp.............	0	1	1	2
+15333	PF15477	SMAP		Small acidic protein family	Coggill P	pcc	Jackhmmer:G2TRQ9	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	23.10	23.10	23.60	23.60	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.49	0.72	-3.71	65	309	2012-09-25 13:57:31	2012-09-25 14:57:31	1	6	154	0	194	283	0	74.90	31	22.26	NEW	p.W..ssu...s.......h...G.ssp+p..pKFhRLMGupK.......................tsss.s..ts......p..s...............stu....tsppcppclppcLEpQaptu..hph+......G..p+.+..GLG	.......................Wcss...sF....s..sc-pp..tKFh+LMGstc..................................................csss.sts.......p.s...............................sth....tstcppcclppsL-pQYptuhstp.......tpp.+...GLG...........................	0	51	78	127
+15334	PF15478	LKAAEAR		Family of unknown function with LKAAEAR motif	Coggill P	pcc	Jackhmmer:Q8TD35	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 119 and 235 amino acids in length. There is a conserved LKAAEAR sequence motif.	27.00	27.00	37.50	36.10	24.00	19.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.76	0.71	-3.91	8	31	2012-09-25 14:00:14	2012-09-25 15:00:14	1	2	25	0	19	27	0	117.80	48	65.91	NEW	.PKNWpphospcLpKhuPQpRSRYLAYE-ssK-lt-..shuhshKRl+-..hptch.scPR.shsp-h.l-+-+ps+LIGQLKAAEARNRlRlMRLRYpthRApElpHLIuCQPTAhKAlRLEuhlPPplcsspssDhLDKh-	...........s.s+shhtho.ptLtth.stp+p+hhhatc..ccl.t..thuhhspcShE.........sh+h.sDPR.shopslplssc+pspL.lG.LKAAEARsRlRshRLRYs+hR.A-EIshLIppQpSARAAIRLEhFLPPQLKPs+IsDPLDRpE................	0	8	9	11
+15335	PF15479	DUF4639		Domain of unknown function (DUF4639)	Eberhardt RY	re3	Jackhmmer:A6NN90	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.	27.00	27.00	29.70	29.20	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	576	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.86	0.70	-5.86	12	53	2012-09-25 14:32:57	2012-09-25 15:32:57	1	2	36	0	32	52	0	368.20	40	88.05	NEW	QERQsR.DRGVTRSKAEKARPPTVPVPQVDIVPGRLsEAEWhALhALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPFTISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPhACTTDuWAQGSVPVLHAPAs.GlE-pFQuE......D.GusDph.LGRSWhsRGSQE.hpShE.SsEh+hh..susssTsELFQEAGPtssLEEsDsQtp...........uth.....AtS.ssShQ....SsEhssstSPcsSLELo.VASsQAsscRuQPhuSpLSLEDLYhChPQ.DAAGDRL.chcpEGhPplASss..ussShGssT.hsPSsShps.ppPh......ss.p.Rhs+KssssRLDPARLPRHWVRPLAEVLlP............DSEs+PLEsYRGRpRspKTcA...pAtPQusssGsRVSsAsF.....FPLpPusPFRALGss...tlp.PTLNLu.sSPshsSKlPFPSPGlRFLssHPshPDVARSPSPKLWPuAKWPSGWEtEAELLGELWAGRTRVPPQGL-ssD+..cuQDsttWPpssPQVLEATSQVhWKPhLLPEAhKLAPGVSMWN.oTQVLLSS....uVPppEcccGosssP....-QpPIQTGsPKP	.................................................s+o+sEKs+........s.ss..VP....pV..D.......IVPGR.lsEuEWhshhshEEGEDhVuDIluDllscVM-ssa....clYLspQslPFTlsQA+-AMLQIsEWRFLARDEGEssVApDP........TWsEDEE.P.sssTDuWAQGSVPV..Lpsss........u.cp..........hpsp..............................p.tt......ht...hht..ptSpp...............................t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	12	13	15
+15336	PF15480	DUF4640		Domain of unknown function (DUF4640)	Eberhardt RY	re3	Jackhmmer:A8MTZ7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 306 amino acids in length.	26.00	26.00	26.70	26.70	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.97	0.70	-4.84	11	31	2012-09-25 14:47:49	2012-09-25 15:47:49	1	2	21	0	18	37	0	230.50	51	92.00	NEW	SSscSNLSLSVGYFPCE-TaSYE-TsSpEDssS.ssSlHFLPPIQGoWpTESTtRLhtRRDQlpDsPEQFCKLSITLAWDlDVuSssSDSluNWDLsucsQWhDKaPE-cTpLTLuKLDsLVQKLEpFLENcKssccDDSlhPESsQE......EDhpLsSSoPPchAQl...SHQEHsoCQDLPph+s.ENE-lhQhPphP.RLpcpE.sc.hoQuoGSptssosETSSlSoGpsEc-s.....ssSshQsLSCLNFtW.VFRWLRpQVhSSLhRRccPp.cATcusHphAtK+RhSaRuKRIQPQE	...........................SpspSNLSLSVGYFPCEDT..hE-TsuhED.ssSpss.SlHhlPPIQGsWtTEphtRhhpRpDQIQDpPEQFCKLSIhLAW....DlDluSsso.DShsN........h.LsucNpWhDKhPc-cTpLoluKLssLVQchppFLEN.Ks......DDulhPcosp................cDhQLsouSPPchsQs...SHQEassC.QD.s.hps.cNcclh..........t.Eh.........sphhsQuTuSQpTsssEhSSl.StpPEc-D.....TsSpTps.sCLNFtW.sFpWLRpplhSsLhRRccP..pATcusHp.A.p+Rh.aRuKRIQPQE..........	0	2	2	2
+15337	PF15481	CPG4		Chondroitin proteoglycan 4	Coggill P	pcc	Jackhmmer:O16883	Family	CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification [1]. The family is rich in conserved cysteines.	27.00	27.00	28.00	27.00	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.52	0.72	-11.24	0.72	-3.65	15	49	2012-09-25 14:50:01	2012-09-25 15:50:01	1	3	10	0	44	41	0	91.60	21	27.44	NEW	sCh+pChsslhcslpthhp.hsp..ps-phcslCspaspuppCl.pp.ttpCcp...phFsshTSuhcahCl-pc-sassphsClptssuslppcC-ppCpsp	....................C.ptChpshhp.hpthht..tp.......shpphpplCptasputpCl.pp.ptpCsp...tthhpthosuhcahCs-pct........tFppphsClst...ss.h.ptCcppC...t.....................	0	17	22	44
+15338	PF15482	CCER1		Coiled-coil domain-containing glutamate-rich protein family 1	Coggill P	pcc	Jackhmmer:Q8TC90	Family	This is a family of coiled-coil family proteins found in eukaryotes. Proteins in this family are typically between 160 and 397 amino acids in length.	27.00	27.00	38.10	37.50	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.68	0.70	-4.70	7	24	2012-09-25 14:58:47	2012-09-25 15:58:47	1	1	22	0	14	25	0	187.80	59	55.95	NEW	Tlsp+EDPLNL........GG..GWApSssLpoWSSCHRRRRGAPhY+RRaRYGPKsEYEPPRKQPKQQHuPGsWFQ.PPRpP.h.VhSNWG+WGGPW+PPPssFhKPPs.VQhIRVYGLpPlCL.CCCSCWsGPWNPGWhRPPGRKKRWGRR...GRGLRRpPRRShPRuPP...sDLShLLRPVNLYGWRAPGMRAPpNTTQFIMNQIYEDMRQQEKLERQQEALRAQQA	.................................Tlsp+EDPLNL..........Gs.GWApSssLpoWSSsHRRR.GAPhapR..aRYuPKsEYtPPRKQPKQQHuPG.WFQ.PP......lhsNWGphGGPW+PPPssFp+..s.VQhhRVYGLHPLCh.CCCSCWsGsWNPGWsRPPGRKKRW.GRR...GR..GLR+H...PRRS.P.RsPP......sDlSpLLRPVNLYuWRAPGMRAPpNTTQFIMNQIYEDMRQQEKLERQQcALRAQpA........	0	1	4	6
+15339	PF15483	DUF4641		Domain of unknown function (DUF4641)	Eberhardt RY	re3	Jackhmmer:A8MYA2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.	27.00	27.00	122.20	85.00	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.43	0.70	-5.77	16	39	2012-09-25 15:14:33	2012-09-25 16:14:33	1	2	19	0	19	45	0	376.40	41	87.67	NEW	pEGcPGo.PsD-cts.slD..h...Lu..-psAAIhp.LoshpshtVp+pPSPEus....ss-suslWA-lEsGPuuRGA.u.............SssEup.pASAusLalsGPttGRAWsss+Ruop.SRhshsss.QpssscG.sthsS-sE..SSDEho-lQhMRVoIphKc...GuQAKssSsccsuDosRHosspsREsFlpVPGshLoSAsRGLoss.lERQA.sGEh-sS...s.KKhpShlWGKtsuRPSasGuAs..................uGuLP+uoPR+KhAQEKKSLGsASchsLGR...sFPsWGQRlSAuPsEPATFPPlSGVsLLG+Sp+.u.ls.tPKpsKpsusGKKsu.u++sREsps...sutEDNDPsRDssspuQlPTHRPtss.....shpsH+GEhSSG-sNhRusQsPGsSpssALSQuulhPRtsAsSGD....QpPss+ssRP-....R.QQpPPGtQGCPRClhLQ+EI-DL+-QLuuhpuLu-+FQ	........EGpsuo.PsDcpts.sl-..h...Lu...pssslh..ho......lpc.Ps......P-ut....sttsus.hssh-sGsstRuuhu.............ussctp.psouushahsG.t.tGRAWtsPcRusp.uRhshp.s.Q.Ps..........o.c.s-..SoDE.s-l.hh+VslphKc...ssQA+ssu.pc.s-ssR+sshps+-sah.lPushLoSsspGLoss.hER.u.sGE.-sS...s.KKh.uhhWGK.tsRPShsssss..................sGsLPpsssR+K.sQEKKS.ussSphs.G+...sFPsWGpRlpuAP.-PAThPPlSGVsLlG+op+.......sKpsKptssG.KKss.u++sREsps...sstEDN-PsRD.sspuQlPTHRst.s.....shsha+GEhSSGD.NhRusQlPGsSp..uhSptslhPRt..uPSGD....Qps.scsstPc....R.QQ.s.GspGCsRChhLQ+EI--L+-QLushp.h.t...........	0	1	1	1
+15340	PF15484	DUF4642		Domain of unknown function (DUF4642)	Eberhardt RY	re3	Jackhmmer:A8MZ97	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 196 amino acids in length.	27.00	27.00	88.90	88.80	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.13	0.71	-4.25	11	23	2012-09-25 15:24:08	2012-09-25 16:24:08	1	1	20	0	13	25	0	142.90	58	83.00	NEW	Capu+pcEETEKsPCTsuNsGEDC..sAANsEpsNscDQEK.hlhphhshshPhRPGILVQRpsK-.hsTsLtNpc-hEsccEs+hK-+QcPcsutEssQE.sD.lpKs.Isloto.SVs-sQKRPLKGVTFSREVIVVDLGpEa.PsPRSYTREHKERK	.......hhpsppscETcKsPChssstG.cC..sAAps.psNstDpE+..llhQlhshssPMRPGILVQRpoKEshsT.PL-N+c-hEsEEEsphpEKQEPc.NAGEsuQE--D.LQKh.IslT+TsSslEsQKRPLKGVTFSREVIVVDLGpEY.PsPRSYTREHKERK	0	1	1	1
+15341	PF15485	DUF4643		Domain of unknown function (DUF4643)	Eberhardt RY	re3	Jackhmmer:A8MZF0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.	27.00	27.00	163.60	129.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.07	0.70	-4.92	10	19	2012-09-26 07:55:05	2012-09-26 08:55:05	1	2	16	0	10	13	0	231.20	53	73.08	NEW	spDuDtuPssPosQPLlPVAHIRPLPsuAQ......ssSPpPEEPsV.......s+sPPuFQAS...VsREuusRVVV.PIAP..ThRSsuPSsaSlsPsuP-up+lEc.Ph....AuPusEAcpVsSsstuSosu.sSsPHPsPsP+VAPKP.............+hSGWTRLKKQLhEEAEEP.aPp.ptsLEsp..t...ppEsstP.........ss+sPsSRAS+MWDAVLY+MSVAcs.ps+.sGPssuE+oh..............uul..oRLP.FLYRPRFNARKLQEAA.RPPPTlpsllEL........sPpPKNFNRTAsGWRL	.....tDuDtsPssspsQPLlPVAHIRPLPTusQ......usSPhPEEPsl.......sRPPPuFQAS...VsREuusRVVV.PIAP..Th+S.tsSsaShsPhuPttcplE-.Ph....AuPAsEscpVsSsshASuPs.sSGPHPsPsPKVAPKP.............+lSGWThLKKQLhEEs.EP.hPt.p.sLEsp..t.....cssts.........sspsPsSRAS+MWDAVLY+MSlscs.psp.sGsssup+s...............usl..oRLP.FLaRPRFNARKLQEss.RPPPTlpsllEL........sspPKNFNRTAsGWRL..	0	1	2	4
+15342	PF15486	DUF4644		Domain of unknown function (DUF4644)	Eberhardt RY	re3	Jackhmmer:A8MZG2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 191 amino acids in length.	27.00	27.00	54.80	54.60	16.90	16.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.07	0.71	-4.28	7	34	2012-09-26 14:07:21	2012-09-26 15:07:21	1	1	24	0	17	35	0	151.20	72	86.36	NEW	.AVShAtG+PuHsDsPPNIYEGGLGspQpQCPSsQGSKPKNFRLRHLRGLALYLPuHMQPAGQCESHWLuRLMuGGCLPp....PE....GsAWsLc..LPQGsLuPsNShCoAhLEAplPRDSLGsTASSSShDPsKGs.sQPuPsEG.GlRPKRSWGshEEuhCPLCKR	....................DAVS.AtG+PuHPDsPPNIYEGGLGuQQp.QCPSAQGSKPKNFRLRHLRGLALYLPGHhQPAGQCESHWLGRLMAGGCLPp....PE....GoAWsL.D..LPQGTLGPGNShCSALLE.ApLPRDSLGsTASSSSMDPsKGs.sQPuPsEGLGLRPKRSWGs.EEshCPLCKR....	0	1	1	3
+15343	PF15487	FAM220		FAM220 family	Eberhardt RY	re3	Jackhmmer:B1ANY3	Family	This protein family is a domain of unknown function which is found in eukaryotes. Proteins in this family are typically between 217 and 277 amino acids in length. There are two completely conserved residues (S and L) that may be functionally important.	27.00	27.00	41.40	38.80	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.70	0.70	-5.03	11	40	2012-09-26 14:59:18	2012-09-26 15:59:18	1	5	26	0	18	42	0	241.00	47	83.03	NEW	+DtRsslslsLhsh+suct.......DsD+Lhpslppp..............pcssh...........p-..ssshsspPsst.pGsSptpth.Ssch+pstShu..u.lh+uuppsLP....l+posptsSsuuuups.................cuVsh..tP..tcE.pFssl.ssls-AllsDWLt+ss+ssssh+sWsppG-s.......WlStlPspQKl....hEhGllcDE..sAhhcGlusc.lp.ssLculLSAllppYP..psLhssEs+pVFL-hLpshhScpThEYKKhLSsl+soosshQlshhLLAlpuFsLh	...............................................................RD+RGsLGoCLApVptutGu......DSDKLshuLKKR...............EusaP..........uD..sPSWhsKPsV..DGNSQuEuL.SlEM+ps.StA..uLhLHuGsslLP...al+ESlRRNsASAAo.S.................pAVuLhsAP..oE..pFApVuCussEALh.p.DWLutusRATcupRGpC.KGEs........hlScLPp+QKL.....EMG.hpD-PPsAhscGLGoE.LE.SsLHSlLSAsL+shP..-VLLs-ETKplFLDpL.............pPhFScQThEaKKML...KsTocsLQIsLuLLALpsFpLh....................	0	8	9	11
+15344	PF15488	DUF4645		Domain of unknown function (DUF4645)	Eberhardt RY	re3	Jackhmmer:B1ATL7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.	27.00	27.00	52.20	52.10	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.85	0.70	-5.25	7	21	2012-09-26 15:18:55	2012-09-26 16:18:55	1	1	18	0	11	21	0	273.50	64	98.88	NEW	MAClENVLGGHAsSPhsVss-cNuspEs+..sh.LQC.SSh.+...-DsEsWG+PpVsLRPPhsVLoDLsRpQLEpPSERTGSCIPVsssRAL+pPYsPPPAlAEESLATAElNSSEGLAGhRQcGQDSI.NVSQEFSGuPPALMlGGTRVSstGTERGGNNA+hYssLPRGQGFFPPRGPQlRGPPaIPTLRSGIhMElPPGNsRMAs+c+LA+VSFP.GuPRHPhcNWPRP..lPLSSSTsGLPspooAHCFIPPp.PPSFNPFLAMPhAFAPPPlFuPPLPSYFupFPShGMPsPussN	..MACIENVLGGHAPSPhlVssDcNGNpE.+..DhPLQC.SSh.c...DDAEsWGpPpVsLRPslNVLTDLspcQLEtPSERT.GSCIPlcS...RAh+HPYGPPPAVAEESLATAEVNSS-uLAGWRQcGQDuI.NVS.EhSGuPPALhlGGT+VsNtGTERGuNNARLaVALPRGpGFFPPRGPQVRGPsHIPTLRSGIhMEVPPtNTRhAs.+t+LAHVSFPLsGPpHPhcNWPRP..lPLSSSTPGLPsCSTAHCFIPPR.PP.FNPFLsMPlsFAPPPIFGPPLPSYFupF.ShGMPAPAssN..	0	1	1	1
+15345	PF15489	CTC1		CST, telomere maintenance, complex subunit CTC1	Coggill P	pcc	Pfam-B_19246 (release 26.0)	Family	CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. Mutations in human CTC1 have been recognised as contributing to cerebroretinal microangiopathy.	25.80	25.80	26.50	25.80	25.30	21.30	hmmbuild  -o /dev/null HMM SEED	1144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.30	0.70	-13.98	0.70	-7.22	13	86	2012-09-26 17:22:21	2012-09-26 18:22:21	1	5	45	0	49	95	0	701.10	36	91.14	NEW	sLPLSYSFVSVQ-L+TaQ+LPCCSHLSWSSosYQAWApEAt........PsGsPLPREpLLLLGTLTDLsuDhEpEsRsGuLYVRDNTGsLsCELlDLDLSWLGHLFLFPoWSYLPPAphsSst...pGHLELhusPVPVhPLslSPsPhTPlPVLYPEpASpLLphRsKhRsspsNLAG+LVRlSALV+oppKsYFlLSLG.t.s....sAsopVslIVQlPuQLVWH+ALpPGcuYVLTpLRVoplRG.+ppRVWsTosSScLhsLcPpsVREhEl-htt..........shL-AsspshstPosSQDt......t.psLlRpS+lLsYpGTVTcVLNpsAGLYELDGQLsLCLAYQQhpuhRRVlRPGssLELpDVHLLQSlGGGTp+PVLAsCLRGuVhLpuFSppc.PtspsSaps.GAuLaEpLlWE+pLGLPLYLWAs+ALcELupKLCPHhLRHcQhLpaSuPGsPuLGLQLLAPsL-lLtsP.ssstRNsaoEILEEPH+CPLQKYopLQTPsSFPTLssLpEE..uQ..p+AWASFDP+uLLPLPEAuHLTSsQLNpRLAWSWlCLhPosFpPA..VLLGVLVASScKGsLQLRDpo..GSLPCLsLscspQ...PhhDs......plIGCLVRlE+FQLVlERpV+SsFPSWKELshssFIQK+pARVYlQFhLuDALILsVPRs....ssssso.Ppst.........................spPEGPphGQSRLFLLpHKEuLMKRNFssssusSs-sspPsLSFpVsGoWLGGTQR.KEGouWGPPEspt-...EspDQKVhLlFhGSSVRWFtFLHPGpVYRLVAsssssPtlhcttsuSslSpRsLELuussSCLTVQc-WTLEhtuup...DlsssLshs+sLs..ESSLo-LLSuN.ssSLVSFS.AEILSR...sLCpslssshhh+s........Gsusus+psVKLTVAL-sADschPPH.LDVYIE-PHhPsPLGLLPGARVaFSpLEK+VSRupNVYCCFpsoThVpVLSF....PsEoshSsPLPHIaLAELhpGspsPF.pAosSCHlVsVhSLpLhWVCAHCTSlCsQG+CoRQuPsCPoQooVSQAsI...RLLVEDGTAEAsVTCpsHpVAsALGLsPoEWsuLL-tVRsPG+VALQFpGsGA..QsESsucs--PLohFLpTL.CTSsuVLRPlhLoFcLER+Po.clhPLEPPRLQRFQCGEhPhLTRVNP+LpLoCLSI	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................shhlpa.GhlTtllp...s.ulY..hDt..plhLChsa..h.t.hthhR.Gsplpl.psHhh...t......h.h..C.hutl.l.taot...s..............................................h........................................................................................................................................................t.......hl.Gh...tt.pu.h.l.Dtp..ttl.Cl......t...s..ss.......................hhushl.phpch.llhEp...sthso..................pph.hYl.h.hscshll..s.s..................................................................................................................p.......h.hhh.thchl...............................................................................................................t..h.......sh.l..t...p..........................h.phhtsp....sphlshp.s.h.......hh......................s...t..h..thtltlphtt.t.....lplYhp.sths...hGLLPGstlhhpthp++lS+.ttslYsp..s.so.lplhuh...............s...............PhhhLh....ttt.............u.h.splsslh.lpl.WhCshCt.........slh.ts.t...........C........C.s.tsh.ps.h...phhh-.DGoupAhh.hps.t.lh.hLtls...htsl.t.h...Gpl.............................................................................................................................................................................................................................................	0	16	19	31
+15346	PF15490	Ten1_2		Telomere-capping, CST complex subunit	Coggill P	pcc	Jackhmmer:Q86WV5	Family	Ten1_2 is a family of primarily plant and vertebrate telomere-capping proteins that is evolutionarily related to the mostly fungal family of Ten1, Pfam:PF12658.	27.00	27.00	27.90	28.10	26.20	26.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.19	0.71	-10.21	0.71	-4.51	29	82	2012-10-03 20:18:03	2012-09-27 10:45:23	1	5	69	0	56	78	0	112.70	36	82.16	NEW	hspsGshhhh.E.l...uusth.pGpolRshGRLppYDhtpuhusl...........ssspppltVsTph..lcshps.........plGSlY.hlGElppp...pssts..............llpARVhpsVDGlDlsLhcpAlp.pRpahpc+	....................................h..psGhhhh..E.l........uus.h.pGtolRshG+LptYDhtpuhssl............tssppplhVsTph....l.cshph.........plGSlY.hlGELptp....pssss..............................llcARVhpsV-GhslsLhcpAlp.pRpa.pc..........	0	19	30	42
+15347	PF15491	CTC1_2		CST, telomere maintenance, complex subunit CTC1	Coggill P	pcc	manual	Family	CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. This family largely represents sequences from plants species.	27.00	27.00	35.20	39.70	24.10	19.90	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.89	0.70	-5.40	11	18	2012-09-27 10:28:16	2012-09-27 11:28:16	1	3	14	0	13	19	0	276.80	36	26.22	NEW	sslspPslLsGpLtLs.....ots.s.sspppChthoD..........uuusVCCsllch-hsslG+cIpVhuWNalPstp......ssG.....hLEllchphs-sss........hs+...........ssslcolPLt.....ssppssuKsRhslpGlLcSVSPlhslPpt.stpsu...............................ss.hGFlsplhsCtCc.hhtt.............psHpFsp.hh.........VYFsGu.uupW+PVLs+hVGphVslSGLKKKlVhlGccsSpl.haVuTpcohlthss.t.phh...hpps.h.h.GcChGpYpGlVoGlYhQGhllELDc....pVWLLlTDp.Ls....ssHuLRVGAl	......sPlspsslLsGsLsLP.....ups.s.sspppChphSD..........uuuoVCChlLcF-.cAlG+cIpVLuWNaLPshpp.....uuG.....hLEllcW+hs-sss........hsc...........suhlpolPLt.....ssppsctto+hpVhGVlcSVSsVhsVPptsttusus..............................sN.sGFlsclhsCtC+.hph.............spsHpF-tphF.........VYFssu.uupW+PVLs+hVGc.VslSGLKKKlV.ls+csShh.hhVoTccohlphssst.thh...hsps.....GcChGsYsGhVoGlYhQshllELDc....pVWLLlsDQhLs....ssHSLRVGAh..................	0	4	7	11
+15348	PF15492	Nbas_N		Neuroblastoma-amplified sequence, N terminal	Coggill P	pcc	Jackhmmer:A2RRP1	Family	Nbas_N is an N-terminal family of metazoan sequences. This domain lies at the N-terminal of several WD40-containing proteins. The human protein is over-expressed in neuroblastoma cells [1].	27.00	27.00	27.00	29.90	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.78	0.70	-5.30	4	74	2012-10-05 17:30:43	2012-09-27 13:19:37	1	8	57	0	54	74	0	243.70	51	15.14	NEW	WHLVLASNGKLLAsVQDQCVEIRSA+DDFGSlIGKCQVPKDPNPQWRRVAWSHDCTLLAYA-STGTVRVFDLhGSELFVIsPusSFPGDhSYAlAGLlFLEYpuSAQWSAELLVIsYpGpLKSYLV..SVGTNQuFQEsHoFSFSSHYsHGIToAIYHPuHRLLLVGGCEou..-sGhSKASSCGloAWRVLSGSPaYKQVTShEDDlus.sp+pGhh+h.Sh+haSRpupEpDGVF+MSLSPDGTlLAsIHFSG+LSlWsIPSLKQpGpWtQsEQPGaD-INPEW	...............................................................................W+llLu..ssGKLLAslQDpslEIRSA+D-FsSllGKC.Q.V.PKDPpPQWRRlAW...S...DCTLLAYA-SoGTV+lF..DLhG.oc.LF.lIsP...u...s....o....h...s....G.....D........l....ShAIAGLlFLEY.+.u.S...A...QWSAELLVIsYcGpL+SYLV..SluT.NQuaQEsHs.FSFuuHYspGIsoAlYHP.uH.R...LLL.....VGGCEss......-..suh.S+...AuusGLoAWRlLSGSPYYKQ.Vo.sttDplsssspphulh.+..hh.s...........hphao.+p...spcpDGlF+MSLSPDGplLAsIHFSGcLSlWslPSL+.ptpWp.sEQPGaschsP.......................	0	18	22	35
+15349	PF15493	YrpD		Domain of unknown function, YrpD	Coggill P	pcc	JCSG:Target-418961/SP17457A	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 236 and 351 amino acids in length. The member from Bacillus subtilis, UniProtKB:O05411, is named YrpD.	26.40	25.50	28.00	26.20	25.90	23.80	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.55	0.70	-4.69	8	35	2012-09-27 13:15:57	2012-09-27 14:15:57	1	1	27	0	9	35	0	192.80	53	73.28	NEW	AstlscGIGGRshlNSo....GuhlsTKlpLPosspls.....ssGssYIYoGF..oG...........ssEuDhGLpYS.......ssYsV..WKP..hhKlGucsppsstYlp.....GhschTYpNGF+PGosVQLTlYKNhNGsT.....RholhGT..........ssDsYsspIIpElssoNluSlopWKhLATlAsossstpp.......hpupFoNIslDupuhTPV......lDspDaApVTl.SGNoVolsV	..........ASQLscGIGGRAYLNST....GulhsTKIpLPoohpl.......SsuTsYIYSGF..oG.........GTEADIGLQYS.......cpYNV..WKP..lMKVGSKspsp..YlE.....GtspFTYsKGFRPGSTVQhTIYKNLNGNT.....RhThWGT..........NNDGYTGRIIoElptTNlGoISKWKsLATlAsotpsQp.h....usFSTuFsNITIDNKAlTPV......lDTQDFAKloV.SGNsVohSV........................................................	0	2	3	3
+15350	PF15494	SRCR_2		Scavenger receptor cysteine-rich domain	Coggill P	pcc	Rawlings ND	Domain	SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.44	0.72	-3.75	47	411	2012-10-03 20:35:02	2012-09-27 15:58:16	1	29	62	0	195	605	1	92.80	28	15.67	NEW	utshlLpVhsstpssWhsVCp-sWssshGptsCppLGa.....p.sappuhslsshpht.uppFhpL.......ssshs..ltpthp....pssCsSuplVSL+Ch.-CGhps	.................p.lLpVhsstpss.WhsVC.tD.sWspshu.ptsCpplGat.....p.s..tp...p.s.l....t.l.....s.s.....h.p.t...............p.ahpl..............ssp.s.s...l.phh.........pp...sC...sStp..l.VSLp.C.....t..CGhp.s...........................................................	0	14	28	87
+15351	PF15495	Fimbrillin_C		Major fimbrial subunit protein type IV, Fimbrillin, C-terminal	Coggill P	pcc	JCSG:Target-417041/SP13489F	Domain	Fimbrillin_C is a C-terminal family of major fimbrial subunit protein type IV proteins largely from Bacillus species. The family is associated with family P_gingi_FimA, Pfam:PF06321.	27.00	27.00	27.10	27.10	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-10.01	0.72	-3.83	35	193	2012-09-27 15:57:20	2012-09-27 16:57:20	1	3	69	0	26	187	4	85.60	27	16.60	NEW	lphYpsGls.YYphhI+H..Dstssssh.................thuca.GVVRNshYslslsslps.GpP................sssssspss-cscsaLslcIpV.PWshhsQsh	............................hY.puhs.YYphhlcH..sstsssth.................thhca.ulVRNNhYplslsslps.GpP..............................tssssssss-ppp.s.alslplplhPWshhpps.........................	0	7	23	26
+15352	PF15496	DUF4646		Domain of unknown function (DUF4646)	Coggill P	pcc	Pfam-B_61885 (release 26.0)	Family	This is a family of proteins largely from fungi.  The function is not known.	23.10	23.10	23.10	23.50	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.77	0.71	-4.06	20	64	2012-09-28 09:46:54	2012-09-28 10:46:54	1	1	49	0	50	68	0	125.70	22	31.09	NEW	PsuFuRsPssslsYs..sF.pPhplhuh..usp....LssGFshl........PpsL.ssHDVsppDWtRFlcDlptAuhhospp..hhuuhhPlh.hls.........lsuhhhstthccthcs+c....sshlsclI-hWNpsFFpPRt	...........................................h..tshpl.oh..ssp......lssGFsh.........sphL.hppcVs.p-WppFhc.......-lstAspLostp.....phstss.uhs.shhlu....................hG...hsuhhsu+..shcptt.tcp....................puplpshlcpWNpshFpsRt............	0	19	27	41
+15353	PF15497	SNAPc19		snRNA-activating protein complex subunit 19, SNAPc subunit 19	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O75971	Family	SNAPc19 is a family of proteins found in eukaryotes. It is one of the five core components of the snRNA-activating protein complex or SNAPc that helps direct the nucleation of RNA polymerases II and III. The core RNA polymerase II snRNA promoters consist of a single essential element, the proximal sequence element (PSE), whereas the core RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. The SNAPc binds to the PSE of both of these. SNAPc recognises the PSE sequence common to all human snRNA genes, irrespective of polymerase specificity. SNAPc is also known as the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAP19 and SNAP45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAP190, SNAP43 and SNAP50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialised regulatory roles for snRNA gene transcription [3].	27.00	27.00	29.10	29.10	26.20	26.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.22	0.72	-3.78	22	69	2012-09-28 13:02:45	2012-09-28 14:02:45	1	1	56	0	43	67	0	82.80	46	84.02	NEW	EL+pEEcpLL+lhsslp-QLN+LKVEELtL+Shlsspp..tps.sttss.............sppp.shhh...plDsp....spINpppLp.Lshtssh...........pcptEEEc-sD	....EL+KEEEsLLRl+ssLpDQLNRLKVEELtLpShlsupp..sph.ss.ss.............sppphch.h...tl-sp.........spINQppLc.Lshtsph............cp.EEE--p...................	0	7	10	24
+15354	PF15498	Dendrin		Nephrin and CD2AP-binding protein, Dendrin	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O94850	Family	Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.	27.00	27.00	109.60	47.40	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	657	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.28	0.70	-6.02	4	28	2012-09-28 13:42:25	2012-09-28 14:42:25	1	2	22	0	17	28	0	508.80	67	94.99	NEW	MDhQASaWApGPQSRTCt.RPGSPEPPPRRPWASRVLQEATNWtsG.PsElRAREQEKRKAASQEREAKETERKRRKAGGsR..RSPLGp......sR.EPRNu.RsAQPsGhssPsRPERhG.sGRsPRPuAQPQuDPG.AAWAGsWuGRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGoKRGPEhspuPssuAPAPT.suRTEGGRsKKRLDPRIYRDVLGAWGLRQGRGLLGGuPGCuuAtsR.EhuKGuuEKSsGlssAGLNSuuDu+.QucssuuPGsptA.AtuAsuosusPRssPRsR.pL+GScEGKEupEQ.WLPcCWlPSPK+QPsRHSQTLPRPWAPGGTGW+ES.GpR-G..suPch.EsWKtTRRAHTLPRSuRGsAttEGVFVIDATCVVIRSQYVPTPRTQpVQLLPSGtsRssGDu.u.PpPu.cEEGEtAuAhsSsCQKLL.SSRlhcQ.StG....htpEAEuGpstDSSL.cERuS+lLGhPlGEVsltsAP....uQPGSPE+sA.GsAAsssAuss+GSE.ssusPRRAGsGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.tELSV+SGSSDGSDTEAsGASWpsEpo.PthusspPt-GGKTAELpDSIREILDVISQsEEuLFtscDoptsPQGsRc	...................MDhQASaWARG.QsRTCtPRPGSPpPPPRRPWASRVLQEATNWRuG..AEsRAREQEKRKAASQEREAKETERKRRKAGGAR..RSP.Gp......PR.EPRNA.RsAQ.sGhsus.RPERhu.sGRsPRP...sA.PQusPG.uAWAGPWGGRRPGPPSYEAHLLLRGuAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPt.SQsPsSSAPAPs.sARTEGGpsKKRLDPRIYRDVLGAWGLRQGpGLLGGSPGCusu+sR.EsuKGssEKS.GLAAAsLsSGucuHsQA+.ssGusuochsPAGuAsussssPRPsPRSR.HLcGSpEGKEG.pEphWhPKCWlPSsK....KQPsRHSQTLPRPWAPGGTGW+ESLGhtEG..sGPEsLEsWKsTRRAHTLPRSSpG......sutGEGVFVIDATCVVIRSQYVPTPRTQpVQLLPSGssRlVGDuPoQsKPs.KEEGEGAsshPSsCQKhL.SSRl.HQPutG....+shEAEGGcsuDSSL.EERssRILGLPssEVNLpDAP....oQPGSPEHpALGPAAsustutscGSE.ssss.RRuGtGWARTPGPYAGALREAVSRIRRHTAPDSDoDEA.tELSVHSGSSDGSDTEAsGASWRsERT.P.hus..spPpEsGKTAELSDSltEILDVlSpTEE.sLFtscD.+tT.QGsRc......................	0	1	1	3
+15355	PF15499	Peptidase_C98		Ubiquitin-specific peptidase-like, SUMO isopeptidase	Rawlings N, Coggill P	pcc	Jackhmmer:Q5W0Q7	Family	Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes.  Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalise with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology.	27.00	27.00	27.60	30.00	24.90	21.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.99	0.70	-5.11	14	62	2012-10-10 12:56:15	2012-09-28 15:54:51	1	5	41	0	33	64	0	238.60	57	27.06	NEW	hCLQW+NspuLCWLDCILoALVHhEsLKcsl.sphssc.........pcSlht+Lhp+YsQAstLLpssppst.hp.s.t.s..............hhphss-lLscsEo.pLN-lRppIFtpLQPpL+CcL.GchESPVFAhPLLL+h-splEcLFhaSFSWpFECspCGapYQsRshKoLsTFTNllPEWHPLNAsHhuPCNsCpsKSQ+R+MVLE+lsslFMLHFVEGLP+NDLppYSFpFEGshYQlooVIQYpsp.cHFlTWlhsuDGo.WLECDDLKGP.hCp+Hp+hEVPASEIHIVIWE	.............h.slQW+Ns.uLCWLDClLoALVH.csL+psl.sthssp.........pcSlhhpLhpcYspAstLL.spphsthp.s.tp...............hhphssplhsch-s.pLsclRtplF.pLQPpL+C.pL..GchESPVFAhPLLL+h-shhEpLFhhSFoWpF-CspCGapYpsRphKoLsTFTNllP-WHPLNAsHhuPCNsCssKSQhR+MVLE+VSslFMLHFVEGLPpN.DLp..cYuFpFEGshYQlToVIQYpsp..pHFITWlLsuDGo.WLECDDLKGP.pscRHc+FEVPASEIHIVIWE...............	0	5	7	16
+15357	PF15500	Toxin_39		Putative RNase-like toxin	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and conserved cysteine, 	25.00	25.00	148.20	146.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.25	0.72	-3.86	3	3	2012-10-01 01:44:25	2012-10-01 02:44:25	1	2	2	0	3	3	0	100.30	33	10.51	NEW	tE+cssAc+KPADGGHDVVVTP-GVG+CSPPPCPVI+VEYKKELuAcP-LKpWNEoVQuhRKsDPchAAD.............EAAKLIpALEsARsNGG+APsEchV+	tE+cssAc+KPADGGHDVVVTP-GVG+CSPPPCPVI+VEYKKELuAcP-LKpWNEoVQuhRKsDPchAAD.............EAAKLIpALEsARsNGG+APsEchV+	0	1	1	3
+15358	PF15501	MDM1		Nuclear protein MDM1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8TC05	Family	This family of proteins is present in the nucleus [1]. The function of MDM1 is not known.	27.00	27.00	27.30	27.30	23.30	26.60	hmmbuild  -o /dev/null HMM SEED	577	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.29	0.70	-13.10	0.70	-5.57	20	126	2012-10-01 08:54:23	2012-10-01 09:54:23	1	4	65	0	65	137	0	377.30	29	69.79	NEW	SEYpRsFpW+cshhscphsss.t...........pKssaAGL+S....Dph..GIs+EPshhuKRRVPhpcs.plscphcWptsss.p.ssss..csps..sspsppsppptshsptph..s.-ssphs.+spuhussSt.c...s............stpp.thssstts.spps.h..ssp...spphssths+hLpt+AGls.sh.tpphh+s.SEYQpQFsWKssp.ctuPhhsAp.pshtsps.t.hs..saps.sph.tcoEYpppFps.t.sc..p.cpphtt..............ppshcths.pp..pspKts-.hph.csctts.hstsp.c+p.p.h.hp..ph............t+hsoEY+u+FlSPupYhYccGuWs+s................................+pssssp.......st...lsshWYtEVpELREKActYRpRs.pGTHFSR-HLs.QlLocssslWDsSSsoSS-uslSsslpshcLus.............t.cp.p................................h.st...cpp.shccpspcssTtclshustsssPs+..R+LsWtpscss.pcctpppsptptp.........pppppttttpp.hpp.pc.c.pp..................psptsh.stuossuS.lS.........................uscsGRLPTPcL+...ph.sGspRoHaDhTTPAsG.GAVLlSPoKh+	...............................................................................SEYppsahW+p....pt..st.............t....su.h..................u.spEP.h.p+++sP.hs............t.p...........st........t..tt...................................................................................t........ptt.....s..........t..t.p......ss...........h..oEYp....pa...................hhsts..................sthptt.........................................t.hs..t.....p.tc...........php........t...p...t.....................tph..p.t.p.....p.t.a.hptttahh........................................................................lhELRc+At.Y+......pRs..Gschs.c.....lhpcppphW-.sSppSS.t.......slS.s.p...hts.........................................................................................................sh.....t...pcp..psst.pht.st..s.Ps+..c+Lh.s.tptt..p...pp.t.................tt...t.......p.t...........................st.p..tts.tss...t.........................sttstRhspPphh...th....pRh+ts.h.ss.t..t.hss........................................................................	0	20	23	44
+15359	PF15502	MPLKIP		M-phase-specific PLK1-interacting protein	Eberhardt RY, Coggill P,	re3	Jackhmmer:Q8TAP9	Family	\N	27.00	27.00	27.00	27.00	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.74	0.71	-3.51	24	90	2012-10-01 09:08:51	2012-10-01 10:08:51	1	2	77	0	63	81	0	150.70	23	75.75	NEW	P.hs.......t.s....ssph..tt..........hu..tt.......t......s.P...p...........tP..........tt.......................shpptptht.sttp+pstpss...........ps.hG.......pt.t.pt....s.ppYa+PSMLEDPWtpLh.hp.sthspphsssptss	............................................................................................................s.tsssst......................t...t.........p....hG..tst.....s................ts.P...................tttPt.......p.stsPss.........................................................spppthu..hssu...tpppt.pss............sths.ssh.G....phpsRppphsp...........sl-pYa+.P.SMLEDPWtsLpshp.hths.p.ppp....ht.............	0	15	25	44
+15360	PF15503	PPP1R35_C	PPP1R35;	Protein phosphatase 1 regulatory subunit 35 C-terminus	Eberhardt RY, Coggill P,	re3	Jackhmmer:Q8TAP8	Family	This is the C-terminus of protein phosphatase 1 regulatory subunit 35. This protein interacts with and inhibits the serine/threonine-protein phosphatase PPP1CA [1].	27.00	27.00	30.40	29.50	26.00	24.90	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.68	0.71	-4.68	21	62	2012-10-01 08:54:13	2012-10-01 10:52:41	1	1	54	0	42	66	0	138.20	29	58.61	NEW	PphpoolsLppELp.....httt.........chsut+ulpcpLppo...ps+stlp...spsscslNhspsppla+sLVslsVscppll...pptlpc+........pt.s..pchstspPsltpFhcs..p.hhhpssphtscths..phphpspPs.cshhshac+hp	...........................................................Pthpoolslt.Elp....thttt.........phsu.+slpcpLcpo...ps+sulp.....tplscsLNhstscplF+sLVsLpVs-ppll...sttlp-+.thh..t.ptss..pcsssstPchs.hhcs..pphhhpssphhhpsls..plphp.pPs.tshF.ha+ph......................................................	0	12	16	25
+15361	PF15504	DUF4647		Domain of unknown function (DUF4647)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAL5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 282 and 480 amino acids in length.	27.00	27.00	30.50	29.90	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.60	0.70	-5.63	13	45	2012-10-01 10:03:11	2012-10-01 11:03:11	1	2	27	0	21	50	0	351.10	52	88.73	NEW	MDLPDESQWDETTCsLAlCQHPQCWAolRRIERGHPRILuSsCKTPl-sEDKLPsLTlVNIoDSCFtA+R.lspppLstFTFTKs+SLLSpuSKFcSKFQG.Rs.KuLPDK-LIsposRsPKLSVLNLNETpLPsspDVRNMVVlWIP.......EEsEpp...........sSQsGKK+RKKSss.......Ks+s.lhhsG+Qpscoph..psPuhlVPPPSPV+hhEQLSoEulPhWsQhDhLPQDLLK-LLsscGKohPssEMKhQLAMMKKshPLEKsRPDSAISSKMFLSlHRLTLQRPuLRYPEHLKKLa.NLKoE...uh+KQQthQQpp.......VKTPsKKQEAKKKuKuDsGSQsTS+KpsusssaDPhh..spRTL.sppS-hK.QQpthpptGsshppsSTcRsph-hu-pshs.h.....ppcsPELschEsopKDlssphEslLEu.t.....sscsLSsShuphuWNPELKLLRILQATD-EDEE	.......................................................................................McLPDESQWDETTCshAVCQHPQCWAolRRIERGH......P.......RILuSssKT.Ph-sEDKLPsLTlVNIs..DSCFts++......LsthTFoKs+SLLS.tSKh.SKFpG.Rs.KsLsDKslhspspR.PKLsVLNLNETpLPsspDV+NMVVlWIP.......EE.Ehp...........spQptKc+RKp.sscp+..h.....hstpQ.s.t....tsPuhhVPPPoPVph.EQhss-.lPhWsQ.-hLPQDLLc-LLssttpoh.s.EhKh.pLAhMKKshPLE+sRPDSAIS...oKMFLolHRLTLpRPuLRYP-+LKKLa.NLKpE......uhpcppth....Q....p..pp.........sKTs.++QEsK+KuKu-st.Qsspccpssshhhs.hh..t.csL.tppsphc.pp..htp.u.t.ppsppcpsh.ph.ch...........hpssch..hEsspcDlss.h-hh.cs....ptp.shshot.hsphuWNsELKLLRILQsTD-E-EE....................................	0	3	3	4
+15362	PF15505	DUF4648		Domain of unknown function (DUF4648)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAG6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 207 amino acids in length.	29.00	29.00	95.90	95.60	28.60	28.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.27	0.71	-4.05	8	38	2012-10-01 10:06:50	2012-10-01 11:06:50	1	1	27	0	20	35	0	148.90	73	78.47	NEW	VVI-SDLY.spRPLELLPHRoDRhp..ssEuc..RhGRLQsupQ.Gs.sAKTsARPVGISEPKsopLCGNRAYGKSLlPPs....uRIoVKAPs..shEssAsGo-psAlLsRGSRHLKKMsEEaPsLPQGAEASLPLTGSuSCGsPSILRKMWh+HKKKSEYVGATNSAFEAD	...VVIESDLY.sppPLELLPHRuDRRD..sGDuR..RFGRLQsARPPssHPAKssARPVGISEPKoSNLCGNRAYGKSLIPPV....sRISVKsss..slEAsAhGoEpGAVLhRGSRHLKKMTEEYPsLPQGAEASLPLTGSASCGVPuILRKMWTRHKKKSEYVGATNSAFEAD...	0	1	1	3
+15363	PF15506	OCC1		OCC1 family	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAD7	Family	The human member of this family, overexpressed in colon carcinoma 1 protein (Swiss:Q8TAD7) has been shown to be overexpressed in several colon carcinomas [1].	27.00	27.00	44.80	44.60	25.30	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.98	0.72	-4.09	3	14	2012-10-01 10:37:31	2012-10-01 11:37:31	1	1	11	0	8	20	0	57.00	77	93.44	NEW	MGCGNSTAuSAGsGpGPAGoAKDVsEESVoDDDKRRNYGGVYVGLPSDAsNMVSGQTKos+K	MGCGNSTATSAGAGpGPAGAAKDVTEESlTEDDKRRNYGGVYVGLPSEAVNMVSSQTKTVpK...	0	2	3	4
+15364	PF15507	DUF4649		Domain of unknown function (DUF4649)	Coggill P	pcc	Pfam-B_83 (release 26.0)	Family	This family of Firmicute sequences has members that are annotated as ribose-phosphate pyrophosphokinase; however there is no evidence for this attribution. Member proteins are all shorter than 100 residues in length.	27.00	27.00	27.00	28.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.34	0.72	-4.21	14	556	2012-10-01 12:54:17	2012-10-01 13:54:17	1	1	311	0	28	149	0	67.10	50	97.61	NEW	IElTYLDAhKpERploFEsYpEF.pu.puC.lslsD.asVpKlsYpG+cLsYpGsYGDlahahhc.DLopYc	..............ElTYhDu.+sERTlpaEsaE-h.ho.puC.lslsDhh.VppLTa+G+plsYpGhhGDlahaL.+tDh..........	0	4	6	14
+15366	PF15508	NAAA-beta		beta subunit of N-acylethanolamine-hydrolyzing acid amidase	De Vivo M, Coggill P	pcc	Jackhmmer:Q13510	Family	NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, Pfam:PF02275.	27.00	27.00	27.00	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.00	0.72	-3.64	85	283	2012-10-01 15:26:22	2012-10-01 16:26:22	1	8	132	0	173	266	14	88.30	28	24.28	NEW	sslP.ha.slsLDhPPpcRWpplhpsap..splpt.lhp.hlcpllss..hhst...hlhphlsphh.sthh..phl..sps....ascEl+GIAcss...ulsLG-llhhNlhYEl	........................s..sPhaslsLDhsP.cRWtplhppht..stlp...lhp.s.hpphlss.....hhPp...hl.hphlsphl.stlh.....pth...P..pP....ap...-El+GIAsss...slsLu-llhhNlhYEh.......	0	62	81	126
+15367	PF15509	DUF4650		Domain of unknown function (DUF4650)	Coggill P	pcc	Pfam-B_31507 (release 26.0)	Family	This family of vertebrate proteins lies to the C-terminus of Ubiquitin-specific peptidase-like protein family peptidase_C98, Pfam:PF15499. It might be acting as the exosite for the peptidase.	27.00	27.00	27.20	28.70	22.60	23.10	hmmbuild  -o /dev/null HMM SEED	520	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.66	0.70	-5.58	16	46	2012-10-02 09:43:10	2012-10-02 10:43:10	1	3	31	0	24	45	0	485.10	45	49.01	NEW	plLSGscsLVDssllsLTLpEh........QVsSEuh..LEspPVt......EssslscssoLQsQ-...ShhuS.louPscEKlspsphlshSF.oQslssshpssQ.Nstsossstslss.spsss.LhQtlKslch............E......+ssphcphLsscsE...KLpscpsspSQsS.NLKc+pssA.pSpsssupSsQNp...shK-sQKKsFVGSWVKGLLS+GsSFMPsCVSApsRst.........lTDLpsoVKG..AsNFsGFKTKGl.pQ+up+sS+Ksp+ssspssssupssPt..tsssoustsp.ssssAsstlh++p-ssStssphs+sopssEsslSSus+s-usEuQlHKLRLKLLKKLKAKKKKLAuLhSSsps..............GphsS-shEplSps.......GSPNDCESl-DLLpELQaQIDlADsKSusTTssssS.hSuQoHEEILAELLSP.oTlsSoEhScssEsDhRYLEM..GDsphsuPs.PoEhsslspsshLpQDHNYCSPsK+sQsEVQsDSLsNsuCl+TLNLESPhKTDIFDEFFSTSALNSlANDsLDLPHFDEYLFE	.............................................lLSGscsLVDssIlsLTLEEs........plsSEuh..LEs+PVu......ENssllcssohpsQE...ShhuS.lSuPsc-KlhpsthlDhSFsSpslssshp.sQlNstsossspslss.spsos..LlQslKslch............E......+DsphcphLosKsE...pLcPcp.lsSQsS.NL++ppssA.pSQossucShQNp....shKEsQKKsFVGSWVKGLLS+GuSFMPsCVSApsRss............lTDLQsSVKG..AsNFGGFKTKGl.pQ+up+sS+Ksp+ssscPsshupsPst..usssssuhs..spspAsstshcKstssS..t.............suphsHsopsp.sulSSus+t-.sEuQlHKLRLKLLKKLKAKKKKLAuLhSSspp..............tsssS-slEplsps.......GSsNDCESl-DLLpELQYpIDhADscSusTosssso.hSoQoHEEILAELLSP..oTssSoEhScssEsDh+YLEM..GDsphssPs.PoEhsslspsspLpQDHNYCSPsK+s.pEVpsDSlhssuCl+TLNLESPhKTDIFD-FFSoSALNolAsDs.DLPHFDEhLFE............................	0	1	2	9
+15368	PF15510	CENP-W		Centromere kinetochore component W	Coggill P	pcc	Pfam-B_49340 (release 26.0)	Family	CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.	25.00	25.00	38.10	38.10	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.42	0.72	-4.02	6	38	2012-10-10 12:36:46	2012-10-02 12:47:25	1	1	26	0	16	43	0	87.60	64	99.88	NEW	MAlSTTVSQRK.IKRKAPRGFLKRVFKR+KPHLRLE+ssDLL...............VHLNCLLFV+RLAEESRTNACEsKCGVIKKDHVLAAAKVILKKSRG	..........................MA.oshVsp+K.IKRKAPRGFLKRlhK+pKP+LRLppsuDLL.......................VHLNCLLFlHRLAEEoRTNAsEsKCtlIKK-HVlAAAKVILKKSRG..	0	1	1	2
+15369	PF15511	CENP-T		Centromere kinetochore component CENP-T	Coggill P	pcc	Pfam-B_9162 (release 26.0)	Family	CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore.  Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure.  The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.	30.00	30.00	30.80	30.70	29.90	29.50	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.63	0.70	-5.23	40	140	2012-10-10 12:36:46	2012-10-02 17:33:53	1	3	109	5	91	148	1	349.70	26	78.83	NEW	ssTP+uhtu...hphh.t+Rsuh.TPt..psRR+Sspt.............................p+-TPcslL+sLu+sLA.sSpslssSssps......................................ss..ppthp.scp-cs-sp.plptPRLSlPlst..............tcccp.............................-ssc.tPP+hShL.sts............Thp...SlEhsRRsho....p.tshhpchs......ussphSc.....h.s.spl.....ttspsh....sss.....hpssssppshsps.tstsphsppsss....................................................sh..tht........--.tphshths.ssssusstsphtpsps.....s-hptt.sstssstsp.s.t.s..tssssssstpsssptsss..........................stt..ph.hpssssssssspsstsh...sh.......................ppp+lS++.GlshPshPsssVK+lAppau+h.uthuKs+ls+-uLpAlppuo-hFFEQlu-DLpAYAcHA.GRKTI-EoD	.................................................................................................................................................................................................................................................TPht.tu......pRshh.Ts.......psRRhS.p............................pcpTshslL+plhhshs.po..h.pSs.......................................................t.cp.ptp....hPcLp.shs.................tcp.........................................ps....sschS.h.p...s...............ohp..p.thsR...Rs.s......tshhpchp.........ss...t.........ss.s.h......ttppsh...shh.....h.p.p..ps.sp...ptst.st..tsts..............................................................................................................................c-...hsh..th.ssts...s....tptt......tp.t.t..s..shts..p........t..ststtsstpsp..t.......................................................................................psssssttt..h.tst................................................htp+hs+......t...thshPphstssh.Kphhppas+..shhuKh.ls+cslthlpps.-haFcpls-DLpsaApHA.GRKTlc.pD....................	0	15	33	59
+15370	PF15512	CAF-1_p60_C		Chromatin assembly factor complex 1 subunit p60, C-terminal	Coggill P	pcc	Pfam-B_74766 (release 26.0)	Domain	CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family Pfam:PF12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, Pfam:PF00400.	27.00	27.00	29.40	28.50	19.10	20.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.32	0.71	-3.84	16	48	2012-10-03 13:48:41	2012-10-03 14:48:41	1	6	35	0	27	42	0	156.60	48	29.99	NEW	GIPLKEKPVLuV.RTP-TA.KKsK.uQsppsSSPGPR.sEGTPoSRspDPSSPssTPspu+.uPAssu.KDsPuossus+ushsssSEEK.s.QP.ouQNsKup.PRRVTLNTLQAWSK.TTP..RRINLhPLKTDoPssusPssls.SoPSoEclQ......s...EsPuDPpssPPE.KRPRLsEpptuspu.-	........GlPLKEKPVLsh.RT.Ps.TA.KKsK..uQopps.SSP.GPR.sEGTPsu.RspDPSSPssTPspup.uPAsss.h+DsPshssus+us.ss..sSEEK.s.QP.uuQNsKut.sRRVTLNTLQAWSK.TTP..RR.IsL....hPLKT-oPssusssss..osPusEphp......spsPsDs.spPPE.KRPRhpEp.tsspu............................	0	1	4	11
+15372	PF15513	DUF4651		Domain of unknown function (DUF4651)	Godzik A	adam	JCSG target SP18156A 	Family	family of short, secreted proteins specific to the Streptococcus genus, with distant homologs, not recognized by this HMM, found in other cocci. In all sequenced genomes, proteins from  this family appear in a conserved genomic context with an thioredoxin, tRNA synthase and tRNA binding protein, but the functional implication of this is unclear	22.00	22.00	22.10	61.00	21.10	18.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.81	0.72	-4.52	20	335	2012-10-09 15:12:14	2012-10-04 05:16:11	1	1	332	0	21	126	0	61.70	63	63.01	NEW	-+c+EclhpplRpaFSshGpIuVLYlssaESspcplsGGlVhEDGRpapFsYcpGplsYEEE	..M.KTQEELTpIVRDaFSDMGEIATLYVQVYESSLEoLVGGVIFEDGRHYTFVYENEDLVYEEE.	0	1	5	12
+15373	PF15514	ThaI		Restriction endonuclease ThaI	Eberhardt RY	re3	PDB:3ndh	Domain	This family of restriction endonucleases belongs to the PD-(D/E)XK superfamily. It cuts the recognition site CG^CG leaving blunt ends [1].	25.00	25.00	42.40	42.40	21.30	19.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.37	0.71	-5.03	2	3	2012-10-11 20:44:47	2012-10-04 10:36:20	1	1	3	2	2	4	1	154.70	49	96.47	NEW	LFpDc.IIsKlpp+LPYhFQLAELESSRAGKlGMpVGShREcIlSuLLIYKFGEpNVETslPITEPElDVKLFGs.ISIKTIoG+EPsGVKLIWTVDupKA+.FLETW+P+aDhILsHINWuS.GulYYIPs.VQpplFDplG+-KYIKLPKQGTNPRGVElSN-Ah+.lhss-cTMSIpIEWKKT.lpYssFKRWV-LWu-	...LFpDc.IIsKlpp+LPYhFQLAELESSRAGKlGMpVGShREcIlSuLLIYKFGEpNVETslPITEPElDVKLFGs.ISIKTIoG+EPsGVKLIWTVDupKA+.FLETW+P+aDhILsHINWuS.GulYYIPs.VQpplFDplG+-KYIKLPKQGTNPRGVEISN-AL+Ellsc--TMSIsIEWKKT.NlcYSPFKRWVELWu-.	0	1	2	2
+15374	PF15515	MvaI_BcnI		MvaI/BcnI restriction endonuclease family	Eberhardt RY	re3	PDB:2odh	Domain	This family of proteins includes the restriction endonucleases MvaI and BcnI. These enzymes both function as monomers. MvaI cleaves the sequence CC/WGG, where W is an A or a T nucleotide, leaving sticky ends. BcnI cleaves the sequence CC/SGG, where S is G or C, leaving sticky ends [1-2].	25.00	25.00	25.90	25.00	24.10	23.10	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.57	0.70	-4.33	21	77	2012-10-11 20:44:47	2012-10-04 10:53:55	1	2	72	13	23	80	38	220.60	24	68.37	NEW	llschcplpptGalp.....pRsusTGlGcTLEcLLGIpcNN.ctPDat.slELKopR.....p..ssohlTLFopsP....ss.h+usppl.hp+YGY.pcttp........tpLasTlpssphNsh...u...........hh.Lc.......l.c..pspp..l....p.lhhp.c.............phhs.hhshp......tpKppchhaV.Acoc.......hpsspEpF+atcu..hhhss..h..s..p..hhpLlEpGhItlDlcIsph.s..t.s..t.s+D+GsuFRIppcch.shLF	..........................hltpl+pltphsal...........stttss.s.u.l..........GpTLEshLGIttNs.ptPDht.s.hElKut+.....t..ssohhTLFs.pP............ss...pps...s.tth.hppaGa.pppt..........tplapoh..ps..sp.....ss.s...........hhlp.......................hs...ppcp..l....hthp.s..............................th.sh.ph.....................tpKhtpshaV.Acsc.............hpsspchFp.as.....ch...hhh..ps.....h....s..p..FlphlcpGhlhhDhchppt.t..h..t.h+c+GstFRIp.ppsl.thLa.........................................................................................................................................................................	0	5	13	19
+15375	PF15516	BpuSI_N		BpuSI N-terminal domain	Eberhardt RY	re3	PDB:3s1s	Domain	This is the N-terminal (nuclease) domain of the BpuSI restriction endonuclease [1].	27.00	27.00	57.30	247.20	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.78	0.71	-4.54	4	4	2012-10-11 20:44:47	2012-10-04 14:08:44	1	2	4	0	1	4	0	159.80	43	18.68	NEW	.sYsDDEVusFHPICcoALNpALpphGLDspYcVlH..HpslGol.sDFVlhpKsTcKalLhlEVKRp.utVpSTRY+hQApSYl.EAsp.plEpP....YYslTNLEVhshFKaDusRPsVspQllpPSPhcsGsFscshSEhaspLVcsFpslIshsVsDoGoa	..sYsDDEVusFHPICcoALNpALpphGLDspYcVlH..HpslGol.sDFVlhpKsTcKalLhlEVKRp.utVpSTRY+hQApSYl.EAsp.plEpP....YYslTNLEVhshFKaDusRPsVspQllpPSPhcsGsFscshSEhaspLVcsFpslIshsVsDoGoa.	0	1	1	1
+15376	PF15517	TBPIP_N		TBP-interacting protein N-terminus	Eberhardt RY	re3	PDB:2czr	Domain	This is the N-terminal restriction endonuclease-like domain found in several archaeal TATA-binding protein (TBP)-interacting proteins [1].	27.00	27.00	146.40	146.10	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.44	0.72	-4.35	9	13	2012-10-11 20:44:47	2012-10-04 14:39:59	1	1	13	1	11	16	0	99.50	55	43.95	NEW	YpELss+lKKVYu+VRhLDDYHWcIps-pIhGIHKKSsl+lcIclAcu+EcA-KLu.c.K.cssGIcIlVlPsKGTFYl+NGsFIhoh+aL+uTLtDIsDHI	YpELss+lKKVYu+VRhLDDYHWpIp--pIlGIHKKSslRlcIclA-u+EcA-KLAc.c.cssGIcIlVlPsKGTFYl+NGAFIhohKaLRuTLtDIsDHI	0	1	1	6
+15377	PF15518	L_protein_N		L protein N-terminus	Eberhardt RY	re3	PDB:2xi5	Domain	This endonuclease domain is found at the N-terminus of many bunyavirus L proteins [1].	25.00	25.00	25.30	25.20	24.20	24.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.04	0.71	-4.90	11	334	2012-10-11 20:44:47	2012-10-04 15:37:54	1	2	46	8	0	196	0	165.00	60	28.09	NEW	MDstchsQahsRIpss+DsplAKDIssDLLhsRHNYFGRELCpulsIEYRNDVPhhDIlL-hlPuhsshshcIPNlTPDNYllhsG+lhIIDYKVSVusESophThEKYsclhtclhspLslsaElsIIRhsPVspplHlsS-sFhptaPsIslslDFohFF-L+shLYcKFtDDEEFhhhVu	.................................Mp...ht.ah.RI.tsppsp.AKDI.sDLLhsRHsYFG+ELC+SLNI..EYRNDVPhlDIlLDlhP.............slD..P..hsl-sPaITPDNYLalNsh......LYIIDYKVSVSNESShITh-KYhElhcDIts.LulshEIVIIRIDPlScsLHIsS-cFKchaPslslDIsFspFF-L+phLa-KFtDDEcFL.hls.........................................	0	0	0	0
+15378	PF15519	RBM39linker		linker between RRM2 and RRM3 domains in RBM39 protein	Godzik A	adam	Jackhmmer:Q14498, residues 339-411	Domain	A conserved linker between the second and the third RRM domain in human RBM39 (CAPER) protein, also present in other RNA binding proteins, especially those involved in RNA splicing. This linker was implicated in interactions with ESR1 and ESR2. Preliminary results from JCSG suggest that this is a structured domain with a well defined fold.	22.60	22.60	22.70	22.60	21.70	22.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.67	0.72	-3.69	26	417	2012-10-05 14:20:47	2012-10-04 21:53:55	1	17	220	3	225	369	2	75.20	32	17.17	NEW	LD..-sDsuGlshNshSRsALMpKLAR..o-p...ssss...sst.thht.t.th.......sh..s.........hASRCVlL+NMFDPuEEsspsW	.......................................-.-hsGlshss.t.uRhtL.Mt+LAc.......sss....hphss...............ssp..psh.th...sssh.................................s..s................................lAopChhLpNMFsPp...pEppss..............................	0	66	110	164
+15379	PF15520	Toxin_40		Putative toxin 40	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the type 2 secretion system [1].
	25.00	25.00	32.00	303.10	22.50	19.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.09	0.71	-4.83	2	4	2012-10-05 01:29:56	2012-10-05 02:29:56	1	2	4	0	0	3	0	177.20	72	11.02	NEW	RsPhoPhs.Thst.L.sA.AlAhcpA.Gphs.hphlG...GphAhDssspsshAhhs.GhthhputphlsNslPpphARVIPsth.hs.LGhPspSDVFlTAAcDItGLsshQIup+LTIPtSso.FplIcF.TP.sGlASPI.RssPGFlGtGRTLGGAREFsIPNt.IP.sAhhpIl	RSPMSPLGSTFNQ.LDVAQAIAYDKANGTMTSAEVIGNQWGDIAFDAVTTAVGAGVGRGTGLYKGQTLVTNSIPQKVARVIPDGIKTSMLGAPNQSDVFVTAAKDIKGLNAMQIANKLTIPQSSSGFKVIEFRTPMNGLASPINRTNPGFVGKGRTLGGAREFTIPNQQIPKDAIIKIV	0	0	0	0
+15380	PF15521	Toxin_41		Putative toxin 41	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin contains two structural domains, an N-terminal alpha/beta domain and a C-terminal all-beta domain. The domain contains conserved GxR, RxxxoH GxE and GxxH motifs and a conserved histidine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	48.30	46.40	16.60	15.80	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.97	0.70	-5.24	12	19	2012-10-05 01:45:39	2012-10-05 02:45:39	1	2	16	0	7	21	0	254.30	26	28.37	NEW	phhtpppcutplLppVhhlLptG.lphhssptp.............tschphhstsVApsLuHGGRVsIplPshsstpt.........................................shhlsphL.Glspssh................p.sstVhpRhhuTHchplspN................tpFKEptu.....................................hsslpstl...................tpschaGhNlulGGlGppD......................asGDllLPD.GuHGHhalsa+sPosc+sGuL.lGlETsuPuthsshGahHsh+uoEt..ossPhusht.hKsDKlGsh.........thstRhVDLsphst......tDWpthlcchtppatstlt...ttpstppptthhpEhl	.............................................t.h.tpt.pthtlLpplhhlhp.G.h.hhptpt................hsphp.hp.slsphLuHGuRV.IplPshsstpt............................................l..hL.Ghp.tt...................tttV.pRhhuTHphphtps.................phcEptu.....................................hhsltstl....................t.chaGhNluhGGhGppc......................hsGcllhss.GtHGHhalhapsPssc+.GulhlGlETotP.......uthsshGhhHshpuopt..phsPtush...Kss+lGs..........phsshhVDLstht........chhthhcph.ptatttht....tp..ppth.....-...............	0	3	5	7
+15381	PF15522	Toxin_42		Putative toxin 42	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	163.70	163.70	303.20	302.10	25.20	16.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.37	0.71	-5.13	2	2	2012-10-05 01:46:05	2012-10-05 02:46:05	1	1	2	0	2	2	0	201.00	29	8.90	NEW	PtlsAchpsL..AK.RltllGhtssssIa-pcch+hps..AF.++hR-hl-.........AlsusplssWppYspTs..Ss.......VGhHGQl.Gh.hG.hs.c.ssGpthG.......tsRtSHHhsQYLLlpYLpNh+us.p.hsH....+.hh.PshssoGspspuhou.sG+phD..Rl-.Gss.sDRGtshPAI.lAt+THQhGplHIsAt	PtlsAchpsL..AK.RltllGhtssssIa-pcch+hps..AF.++hR-hl-.........AlsusplssWppYspTs..Ss.......VGhHGQl.Gh.hG.hs.c.ssGpthG.......tsRtSHHhsQYLLlpYLpNh+us.p.hsH....+.hh.PshssoGspspuhou.sG+phD..Rl-.Gss.sDRGtshPAI.lAt+THQhGplHIsAt	0	1	2	2
+15382	PF15523	Toxin_44		Putative toxin 44	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved [DNE]xxH motif and arginine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, or Photorhabdus virulence cassette (PVC)-type secretion system [1].
	26.90	26.90	29.20	28.00	25.70	24.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.06	0.72	-4.10	26	28	2012-10-05 02:16:07	2012-10-05 03:16:07	1	16	27	0	6	33	0	83.80	26	8.40	NEW	tssGsC..sstppscLpc-hs+h...Cp.pst..sCtss..sptplht+hcthppCtsuRpplspKCFsG.GDpGHppphspAapshspCpphl	.....t..sGsC..sstppscLps-hsch...Cp.pst..sCtss..sptplht+hcthppCtsuRpplspKCFuG.GDpuHppphspAapshssCpph..	0	2	4	5
+15383	PF15524	Toxin_45		Putative toxin 45	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly all-beta fold and a conserved ExD motif and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 7 or TcdB/TcaC-type secretion system [1].
	25.00	25.00	27.00	57.20	23.00	16.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.28	0.72	-3.85	4	13	2012-10-05 02:17:50	2012-10-05 03:17:50	1	4	13	0	0	17	0	79.20	69	8.50	NEW	WolTuRIphAcLPspG+IRYIPP+sYpsStsLP+GPsNGYlDKFGNEWTKGP...SRT+GQpFEWDVQLScpG+cQhGhho+DGp.HLNlSlDGpITH	.WSITARIQYAKLPRQGRIRYIPPKNYSPSAPLPKGPNNGYlDKFGN.WTKGP...s.p+s.pFEWDVQLScpGhcphGhho+sGp.alNlu.DGpIoH.......	0	0	0	0
+15384	PF15525	DUF4652		Domain of unknown function (DUF4652)	Godzik A	adam	JCSG target SP18005A	Family	This family of uncharacterised proteins from Clostridia and Bacilli classes has an unusual structure of three beta propeller repeats that do not form a barrel, as in well known 6-, 7- etc beta propeller barrels, but instead are stacked in a three-layer beta-sheet sandwich. The function of all the proteins from this family is unknown.	22.60	22.60	23.70	22.60	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.29	0.71	-4.88	7	33	2012-10-05 17:30:43	2012-10-05 06:04:42	1	1	33	0	5	28	0	166.80	35	75.33	NEW	NTspppspccs.ssstcpssscKpspcst...KspssssKphothpFlKKc..lscsocspFsTpWKsSpsspaSACIEGKGs-A.EEGlGKIaIKs.pspphathpIppsp.K.oPKYIEWhDDcNLhVlIupuaGTVSpGGsLYhlNlpTGpso.lhpspD+KpQllSApKpGDp.....lsLpl.VY-DDsh.cSHhEshTIssh	............................................................................................................EuIGclYlKppsssch.hhLpIsp............pp...........phoPK.alhWlDDcNLhVIIGpuaGTVSKGGNLYplNlpssphs.lYcsp-p.KppVlSscpst-p.....L.LplslY-sDsh.csH.EphsIt..t.....................................	0	2	5	5
+15385	PF15526	Toxin_46		Putative toxin 46	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	An RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine residues and and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 4, type 5 or type 7 secretion system [1]. This is also referred to as the E. cloacae CdiAC and has been shown to target tRNAs.
	25.00	25.00	32.80	32.50	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.57	0.72	-3.82	12	100	2012-10-05 10:45:44	2012-10-05 11:45:44	1	7	98	0	10	56	0	71.80	61	27.41	NEW	AppAAKcLGY.pcsp......hSHGphlFhppKs.....shYIo.DhDu......Hs.GGsWKtAso.+sL........spKpsR.GTYDtsLpRIGD	..........A.htAAKKLGY.pthKc.....sppGttlFKKspp.......YIShDhDu......Hp.GGAWKtASS.KNL........spKcTRsGTYDtNLp.RIGD....	0	2	3	6
+15386	PF15527	Toxin_47		Putative toxin 47	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly beta fold and two conserved histidines, two aspartates and a glutamate residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 5 secretion system [1].
	25.00	25.00	218.70	218.70	24.20	19.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.66	0.71	-4.36	4	4	2012-10-05 10:46:14	2012-10-05 11:46:14	1	4	3	0	3	4	0	128.80	57	4.74	NEW	ltPDYATlssGlLSuuuSulVNLYDGTpYlAGGVuQosPSuVSapPGlouTlGWIaGApsApusNSFLNGDGNQAFVSIPTPashNVlGAVTHAYGGuTAIElGlGpPGsloaGlsPWSHosPVsssuK	ltPDYATlssGlLSuuuSulVNLYDGTpYlAGGVuQosPSuVSapPGlouTlGWIaGApsApusNSFLNGDGNQAFVSIPTPashNVlGAVTHAYGGuTAIElGlGpPGsloaGlsPWSHosPVsssuK.	1	0	0	3
+15387	PF15528	Toxin_48		Putative toxin 48	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system [1].
	26.20	26.20	26.80	47.80	23.00	25.50	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.41	0.71	-4.41	9	16	2012-10-05 10:46:39	2012-10-05 11:46:39	1	5	13	0	6	13	1	172.10	31	18.04	NEW	lshGhNhshsaps.G......sFphusGlGlts....sh.GaGcsu..httuathua.....t.sphuYs.sshh.ph.stQpoGslshth.scaplhhEND........hh.Gs.s+D+aRTuAlplsls.....phohGhtlaTGcstcps.hcs.s.shst...................shhshppp.hGshppG...ppY.phushalGhps.....hRlGhsu-p.lRphhQN.lhHc	........................................................shGhshthsaps.G......sathssGhslhs.....h.G.stps..hhhuhhhsa.....t.hphuah.th.h.ph.ttQpoGhltht..scaphhhEND........hh.Gs.spD+aRTuAlplsht.....phshGh.laTGct.p..ps..ct.p...st...................GhhstphphGhshphG.........cpY.RhushalGhss...........aRIGhDu-p.VRchlQNhhhHp.	0	3	6	6
+15388	PF15529	Toxin_49		Putative toxin 49	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system. Interestingly, the toxin is also found in type-II toxin-antitoxin systems [1].
	38.30	38.30	51.40	51.40	25.30	24.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.16	0.72	-4.05	15	25	2012-10-05 10:47:04	2012-10-05 11:47:04	1	8	24	0	6	28	1	88.70	40	7.83	NEW	tpuRstssushPputGpsc.sl.hc.cs..G..plspYsTYsscGh......l.KcaRss..G+sHGslssPpVhE.tppNpsPcushhh..sptc..sRtspPcElP	....h.puRs+ssGP.PcApGssH.Th.a+t+s..G..+lTpYuTYspsGs.....hhKQaRGp..GKPHGsVPRPNVKp.sphNpsPtsppth..PKp+..VRpPh.cEhP...	0	1	5	6
+15389	PF15530	Toxin_50		Putative toxin 50	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly all-beta fold and conserved FGPY motif and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 5 secretion system [1].
	25.00	25.00	143.30	142.70	22.30	20.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.81	0.71	-4.34	5	24	2012-10-05 10:48:05	2012-10-05 11:48:05	1	9	20	0	2	21	0	155.40	71	9.16	NEW	sPPRVQQDsSLAhDhuQcGhsptEIscAlDtSHlGPSWGTEYKV+ssVKupVuuGhusGYpl-GoIDsc+lSVNsG-ThulGA+AGASIGLoFGPYFPGllsss-RDYShulGhGVhSVulSsGKDGlGFSFGVGPSWGaSuopo.stscpVDlNGooToElY+YDFK	SWNQYAQDNNLTPEQVQEGMNRIAIGE.......GPSWGTTYKVHPVVQAGGDVSFIRGYTLSGTIDDNHISVNQGDIYSIGAHGGASIGLSFGPYFPGLINSNDNDYSINGGFGVGAVGLSTGKDGVSFTFGFGPSWGWSATEI....KGVDVNGTSTSEVYRYDFK.....	0	0	0	2
+15390	PF15531	Toxin_51		Putative toxin 51	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and conserved aspartate and glutamate residues, and an RxW motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system [1].
	25.00	25.00	27.70	27.70	22.60	21.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.63	0.71	-4.34	6	8	2012-10-05 10:48:58	2012-10-05 11:48:58	1	5	6	0	5	10	0	125.20	25	7.22	NEW	hGlNspu-sL...sus.Gu..cTasspsYuts.stuhsls-...tPlWpssVcsAltNPsV+IuloLDGh.su..........pshsEAhpsshp+Gcuht.scWc...ttGhGTAWEMscltpAlRhts..............RsW-SIcWYhssccs	...............hGhNshs-tL...sus.Gt..coasshsYups.shshsssp..stshWhssVcsAltNPsV+lpVsLDGhssu..........psh.-AFhsshppGtsh..tsa....ttGtGTsWEMuplupAlRht-..............RsW-SIcaYhsscp......	0	2	2	5
+15391	PF15532	Toxin_53		Putative toxin 53	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and two conserved histidines present in an RxH and THIP motif. The domain additionally has a highly conserved arginine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6 or type 7 secretion system [1].
	25.00	25.00	49.00	46.50	24.30	23.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.35	0.72	-3.81	11	20	2012-10-05 10:50:16	2012-10-05 11:50:16	1	6	20	0	5	21	1	103.50	39	15.15	NEW	scPhshlscssppps..h......psss..pshchKWt......ss..shsaclRlHssDsssstGsNuusG.IaRlp.............hGhcY.hDssGpaa+putlp......hp...sPpasppAuNcTHIPl.	..................................u.sPtchls.sh+ppG..Lp....scshP...thKtKas......su..shpYcVRsHsssPoAPsGSNuusGsIYRIut........tpQGhGhEY.hssDGsWaHpSsL+......spSPsYNssAANDTHIPls.	0	5	5	5
+15392	PF15533	Toxin_54		Putative toxin 54	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and [DN]xHxxK and DxxxD motifs. It is usually exported by the Type 2 secretory system [1].
	26.30	26.30	26.30	30.30	26.10	23.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.20	0.72	-3.72	8	17	2012-10-05 10:51:18	2012-10-05 11:51:18	1	2	17	0	3	16	0	62.90	47	25.94	NEW	NstQDKhLohuDIc+LKcuGhDhH-LK....Gt+.NuS+hDLYKD+c.GNIYlKPKGGpGtG-PTGlNIN	...hptsK.lshs-.chLKcsGlDhH-LK....Gtp.ssSKhDlYhDcp.Gplalh.KGGpGts.sTs..Ip..	0	2	2	3
+15393	PF15534	Toxin_56		Putative toxin 56	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a conserved histidine residue and a KH motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 secretion system [1].
	25.00	25.00	29.90	29.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.55	0.72	-3.49	14	39	2012-10-05 10:52:08	2012-10-05 11:52:08	1	4	37	0	3	32	0	76.20	35	26.79	NEW	hssNKh.pHIhssKHsWsplhct...sapplpslhppsh+pGppsshppushpc.....shphsGpslsVThth.hcGphcI.SsuWVp	...psNKh.pHIht....sKHsWsplhKt...sappVpslhp+sM+pGpposYppS...uhp+.....shphsscsVslThsh.pcGpl+I.SsuWVp....	0	1	2	3
+15394	PF15535	Toxin_57		Putative toxin 57	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and a conserved glutamate residue, and [KR] and Hx[DH] motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system [1].
	25.00	25.00	32.00	32.00	24.70	23.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.81	0.72	-3.93	15	22	2012-10-05 10:52:50	2012-10-05 11:52:50	1	5	21	0	8	21	1	79.00	29	16.33	NEW	ucssus.sspEhht....hssccGhp.ass.sPs...tsG+.uuWhcscsGcsahPssptssst....ptGPHWDVpcPpGt.....apsshPpsh	.................ucs.ss.sspEhh.....hssccG.p....ats.sPs...hsG+.suWhssc.Gpsah.shttsstt....ptGPHWDVpcsput.....acsshPtt.....	0	3	7	7
+15395	PF15536	Toxin_58		Putative toxin 58	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved aspartate, arginine, histidine and cysteine residues that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	32.60	160.10	24.70	18.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.72	0.71	-4.30	3	5	2012-10-05 10:53:14	2012-10-05 11:53:14	1	2	2	0	4	5	0	128.40	56	13.54	NEW	RAGIuVPsAthRYERQEPsAcLQtRARIlASPDVRVAV.PGTRITYsLs+su-.LHApuu.YpYQWYhLNDP+TopTaG+P..ARV-Gu-GP+u-FRAGFVGNHKIICK.Vh..AuGDuQAPVFYEaPQsVVSEGK	RAGIAVPDAALRYERQDPAAELQGRARIVASPDVRVAV.PGTcIoYALAHGoQuLHASSSPYRYQWYhLRDP+ToRsHGEP..ARIDGPDAP+A-FRAcFVGNHKVICK.VTPRAGGcAGVPAFYEFPQTVVPEGK.	0	4	4	4
+15396	PF15537	Toxin_59		Putative toxin 59	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 or TcdB/TcaC-type secretion system [1]. A  of this, the Pseudomonas RhsT-C has been experimentally characterized.
	25.00	25.00	45.80	72.00	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.61	0.71	-4.04	4	7	2012-10-05 10:54:46	2012-10-05 11:54:46	1	6	7	0	1	9	0	117.90	37	7.14	NEW	GohhutsshpcGulssppush+.GSGPssGhlEVS-uhpSoKul+Nats...uGs.-FVFDPppppFshGsst......hpsHptlA+uhG...As-usllGGRh.R.psGplhTsEaSGHYGcpW..osEhRpQ	.......t.ht.hhhhpGuls..sp.shhp.GSGPssGhltVS-pspSstAl+NatP...pGs.-FVFDPppspFssGssp......htsHptLAculG...AscusllGGRhhRsssGpl.TsEaSGHYGppW..ssphRp............	0	1	1	1
+15397	PF15538	Toxin_61		Putative toxin 61	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1].
	25.00	25.00	27.70	27.10	22.80	19.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.07	0.71	-4.23	8	33	2012-10-05 10:57:02	2012-10-05 11:57:02	1	3	32	0	5	32	0	150.90	47	35.76	NEW	RRsYLNcKFGRTGDLs+DINIRGN+EsAssFaKSpGhspsc.hEsYMsGIDFocPVpVETIN+GKpLaQaQsPGuhQ.GsWYSLossVtPTcLGINPpGplauT-hlVPKVhssYQSpcKVplLRSTAAPsLDTWSV.cpPYpAcGGApQhhSspK-lF	..................................RRtYLNpKFGRoGsls+DIshRuN+EhAscFF+Sc..sls.tc.hcsYMpGlDFs+PVpVETlssGKpLWQaQsPG..u..hQ.GNWYoLoPsVpPT-LGINPhGphhtssh....hhsKVLNsYpoTpKVpVLRSTAAPslDpWS....V..tpsYsAcGGApQlhSsp+t.F.................	0	3	3	4
+15398	PF15539	CAF1-p150_C2		CAF1 complex subunit p150, region binding to CAF1-p60 at C-term	Coggill P	pcc	manual	Domain	CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork [1,2].	27.00	21.60	28.10	21.60	26.30	18.60	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.01	0.70	-5.29	4	69	2012-10-05 10:57:55	2012-10-05 11:57:55	1	8	48	0	39	64	0	238.00	41	28.17	NEW	AKEWDEFLAKGKRFRVLQPVKIGCVWAAD.RDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPlSLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDCMIVDVPDAsEVQAPCGAASGAGGGVGVDTGKATLTASPLGAS	....................................................................AKEWD.EhhuKGK+h+VLQPVhlGClW..tut...ts.s.....ss-LclLQpFs.ACh......L-s..s.......spE.-.p......s.P.c.s...o.p+p....p.+..DpQlLsQLLPLLHGNVNuSKhIIpEFQEh.C...Rp.....Gh..h..u..p.t..ss.......S..s................Pup.......oh...p..oPt.sps.sslPSKu+LKR...lISENSV..Y.E.KRPca..R.h.CWYVHsp.VLc..pF..pQ-cLP.VPCQWsYlTp........s........Ps.ss...+.-.D.sG.s.....s..ss.ss.s.p.usP....h....ShKRKssuSMsITpFMK+.tt.t.h.....-.DGFQuD............-Chhht.........................................................................................	0	8	10	20
+15399	PF15540	Toxin_62		Putative toxin 62	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a two conserved aspartates, a glutamate, a histidine and an arginine residue and an RT motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6 or type 7 secretion system [1].
	26.60	26.60	27.20	84.40	26.00	24.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.42	0.71	-3.97	6	18	2012-10-05 10:58:54	2012-10-05 11:58:54	1	6	18	0	5	18	0	113.50	57	17.75	NEW	stspaphNsspDlDhRGpGpoY+-....ALDEAF+RTGlPKcpFsVTK...WuKDcsGKShPVEa...pGPN.GApVNlDlP+hs.....sshssGPcpPHlGYQTsGK.uGuutsRGHIhlDslPssR	.N.LYpYAPNPIRWIDPLGLAILEHQ....SNFDAARRTGFENAGMTNPEDVTFSKVDPKTGTVVEF...KGPN.GAKVAYDAPHAD.....MDVTAGHDKPHVGWQSAGKRGSGGANRGNITYDGPQHPH........	0	1	1	4
+15400	PF15541	Toxin_63		Putative toxin 63	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	140.00	139.00	23.40	18.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.37	0.72	-4.07	4	4	2012-10-05 10:59:14	2012-10-05 11:59:14	1	2	4	0	2	4	0	97.80	47	14.68	NEW	LKGWERAH..GsGhGsEAKtGIhYAP.tVNQElQNRGhEKaIRELa.lspssslKlFhpscshAaP..........GpLhLcolpYcV.tEttstRRIl..F-ASl	LKGWERAH..GsGhGsEAKtGIhYAP.tVNQElQNRGhEKaIRELa.lspssslKlFhpscshAaP..........GpLhLcolpYcV.tEttstRRIl..F-ASl	0	1	2	2
+15401	PF15542	Toxin_64		Putative toxin 64	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains two conserved histidine, a serine, two lysine, and a threonine residue and a HxVP motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7, and MuF-type secretion system [1].
	26.90	26.90	26.90	28.10	24.00	26.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.48	0.72	-3.45	34	374	2012-10-05 11:00:33	2012-10-05 12:00:33	1	12	254	0	20	174	0	87.00	40	46.17	NEW	psp+Qs+HhhGpp.Ycpph....hsstth.Sahh.lsscclpcLlpphuusGpllhs.ptG.appKElIDF.sphIGcsa....hsGca.l.cTshGplHYSK.sG.sHIVPth	......................tQt+H..spp.Y.ppK.....sst.hh....SYhh..ls.pphpclhcc.hhsGsllhs..ccs.FchKplIsa..pplIGKsa.....hsspY.l.ETphGKlHYSK.TG.sHIVPal..	0	6	9	18
+15402	PF15543	Toxin_65		Putative toxin 65	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	206.90	206.10	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.75	0.71	-4.52	2	2	2012-10-05 11:01:05	2012-10-05 12:01:05	1	2	2	0	2	2	0	130.50	37	12.91	NEW	MRRR.ht.hASs.-p.LsFLLstcGpa.......RStRsh+t+.hhpcPD..IVQhGHhhSs....thucc-alMLpsu..N.hsshT....chpGuVhspsAV.ItGhsVDl.TAphWEshGhL.tGTVusuPhVp.P	MRRR.ht.hASs.-p.LsFLLstcGpa.......RStRsh+t+.hhpcPD..IVQhGHhhSs....thucc-alMLpsu..N.hsshT....chpGuVhspsAV.ItGhsVDl.TAphWEshGhL.tGTVusuPhVp.P	0	0	1	2
+15403	PF15544	Toxin_66		Putative toxin 66	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	486.60	485.90	17.50	16.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.59	0.70	-5.13	2	2	2012-10-05 11:01:34	2012-10-05 12:01:34	1	2	2	0	1	2	0	269.50	35	70.37	NEW	hsTulsPph............ulhupspstsppspuhGQslhA.sEl+LhDERshhssLsGR..NLGu-GTYhINPpISATLGts.uch.usPplFhG-polGuHV+LMVpNPQT.pch.sGGapth+FoApYpLKNucoWpTPNMshNhtstNpRtLcGSlsAsusL.Itt.lsVpusApIGss.ooEpshcAsl-EFpLGGosoYasHhHclphhlsSuG.Asup.h-SsGcG.pTscsVaspphstucph-spcGS+sh.p.tphP.RVpMPL.+	hsTulsPph............ulhupspstsppspuhGQslhA.sEl+LhDERshhssLsGR..NLGu-GTYhINPpISATLGts.uch.usPplFhG-polGuHV+LMVpNPQT.pch.sGGapth+FoApYpLKNucoWpTPNMshNhtstNpRtLcGSlsAsusL.Itt.lsVpusApIGss.ooEpshcAsl-EFpLGGosoYasHhHclphhlsSuG.Asup.h-SsGcG.pTscsVaspphstucph-spcGS+sh.p.tphP.RVpMPL.+	0	1	1	1
+15404	PF15545	Toxin_67		Putative toxin 67	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and HxR and HxxxH motifs that is usually exported by the type 2 and type 6 secretion system [1].
	25.00	25.00	44.10	43.20	24.30	23.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.36	0.72	-4.10	7	8	2012-10-05 11:02:03	2012-10-05 12:02:03	1	4	8	0	4	8	0	69.90	47	10.05	NEW	LAsD.KQsphlRGWl+pElp+lcp....sp..........+pslRlP........PGh-LAHhRGhEupKGYuYpYosLQstcLHKhQH+hD	LAsD.KQsphlRGWl+pElp+lcp....sp..........+pslRlP........PGh-LAHtRGaEupKGYuYpYSsLQstDLHKhQH+hD.	0	2	3	3
+15405	PF15546	DUF4653		Domain of unknown function (DUF4653)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAB5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 229 amino acids in length.	27.00	27.00	90.20	81.70	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.78	0.70	-5.08	6	45	2012-10-05 12:37:08	2012-10-05 13:37:08	1	2	32	0	24	42	0	196.70	64	97.68	NEW	MF.AlQPGhs......ctupaLGu.PsuVsp.EhpPDSNSNFVppuhDANENWpth.utl-shh.+SpSE............ScNpshtu.t...........P.......EutVRSPPEGAEIs...GscPEKsscsssss...SPLEDNGYASSSLSlDS.sSSP-susuosp......uP.u.P................sDsLhPoVupAhQQLQApERYKEQEKEKHHVHLVMYRRLALLQWIRuLQppLsDQQsRLQESFDTILDNRKELIRsLQpttsPotsQ-pu	..............................................................................................................................................MF.hhpPshs......ctup.lGs.Psulsp.EhpPDsN.NFhtp.shDsNENWpth.uts-shh.pSpsE............psNpshts.t..................sEttVR..SPPEGAEls...GscP..Ec.sssussp...SPLEDN..GYASSSLSIDS.uSSP-suCuTPp.......sP.u.P.........................sDsLhPoVApAVQpLQspERYKEQEKEKHHVHLVMYRRLALLQWIRGLQppLlDQQsRLQESFDTILDNRKELIRCLQQttsPstspptu...........	0	1	3	9
+15406	PF15547	DUF4654		Domain of unknown function (DUF4654)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NEQ6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 169 amino acids in length. There is a conserved IDC sequence motif.	27.00	27.00	28.00	71.60	21.10	18.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.87	0.71	-3.85	12	24	2012-10-05 12:39:56	2012-10-05 13:39:56	1	1	21	0	14	21	0	132.00	62	78.91	NEW	AppQKAlPsAHLTFlIDCupGKQLSLAAPssPPpuP....pPp.GPVsPPMKTYIlFCGcsp.P.hTQcssLGtssLApA+sTLPPpRGhsAPsS.PsSshsPQEsPcAKGsPlKssss.RSSsWGTVKGSLKALSSCVCGQA-	..At+QKAlPsAHLTFVIDCspGKQLSLAAssuPPpAP....uPspGsVTPPMKTYIlFCG-N..PpLTp.sPhGGGsLAQARuTLPPCRGssAsAS.PlSPhsPQEsPEAKGpPlKssPs.RSSsWGTVKsSLKALSSCVCGQAD..	0	1	1	1
+15407	PF15548	DUF4655		Domain of unknown function (DUF4655)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NEP4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.	27.00	27.00	439.50	198.90	24.50	21.00	hmmbuild  -o /dev/null HMM SEED	532	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-13.08	0.70	-5.60	13	28	2012-10-05 12:43:12	2012-10-05 13:43:12	1	3	21	0	15	27	0	485.20	57	91.37	NEW	lKTNKsGSKVAVSAp+GuEV.ossoPQRGpGY.lhASSQRSAAlSlSPsspR..RSEAApsTo.+SsSDaPRosSPQoGPulSussoP.RGTE......TRoRsEs.............RpsSPpRKsQQsQ..TssSHsluh....pRNVSPsREEuTRRGuEsKsGR.ElopRsSlssDAKSSRRLSFlDpKDNlp.......s.l..E-DPPSKVQsPQGVRVPRRh.laPKDEAVQT......EPIR+.hTsuElRSP+sPsoPE+uSSRhssD.RsspR+lPuQEuEhGPpSSIhoEPKAL+RN..hsLESSLKLSVLKDLDuGHRV.ShRs-PESh+KpSVYsETKPSsKVLIuS-VEosh+SShRuDsEluRRVTISsGsQSlpsspRsTuRssSESP.+KSolasoP-..aKt....p..+Pscsshh.stss.RYs......Es.SpKPSlHA..ELELTPRPLPPRSLPRYGPDSSWWALLNPElEhP.QSpPTT.........PD.....FEPK...SPP.....PLDPhlShaEMDSSPFCEDLhFQREKA........ossP....PssPKESPSpA.PLREVPQ...uP..........KaTsKQPlQRFSAFFLDVSEEMYNRVIWWL	..VKTNKsGuKVAVSApRGuEV.TsToPQRGpGY.llASSpRSAAlSlsPS.pR..RSEAAHsTo.+SuSDYPRSsSsQsGPGh.ussoP.RGoE......TtsRoEu............uRHsSPHpKoQQ.............oQ..ThASHssoh....pRNVSPsREEusRRGGESKsGR.-lup+sS.hPDAKSoRRLSF.DQKsNLp.......o.l.hE-DPPSKVQNPQGVRVPRRhLsaPKDEAVQT......EPIp+hhTsuElRSP+sPo.PEHuSSplusD.pTAQRRlPspEuEsuPhuSI.oEPKALaRN..hNL-SSLKLSVLKD.DGsHRV.Ss+s-PESl++aSVYsETKPSsKVLlSSpVESNVRosIRGsoEVGRRVTISPusQSlpssp+VTupuVSEus.+KSShaVTPEshYKQ....pTp+PscsshMS.GPs.RYP......E..SpKPSlHA..ELELTPRPLPPRSLPRYGPDSSWWsLLNPElEhP.QSpPTT.........PD.....FEPK...ssP.....sLDshLShachDSSPFCEDLhFQREKAS.SP............PssPKEsPShA.PLpEVPQ...sP..........KaTsKQPIQRFSAFFLDVSEEMYNRVIWWL..	0	1	1	2
+15408	PF15549	PGC7_Stella	DPPA3;	PGC7/Stella/Dppa3 domain 	Iyer LM, Aravind L, Eberhardt RY, Coggill P	re3	Manual	Family	The domain belongs to a fast evolving family known only from the placental mammals [1-3]. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization [3]. This suggests that it might bind methylated DNA sequences directly [4]. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion [4]. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins [4].	32.30	32.30	32.30	36.00	22.70	27.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.22	0.71	-4.25	11	48	2012-10-08 22:59:17	2012-10-05 13:55:24	1	1	21	0	18	71	0	155.40	37	88.99	NEW	MD.P.QKhNPshss-S.....S.htstEsSp-ssus..SQPshSEpLhhsLusLosuPGsc.s.sPLPEuLLpQ+YR--..KThpERphERlt....asQRK+phLtplRR++hcHhAPY.....plcc....cu...+lssu.sD..RcQNtFRCcC+YCQSpR.NhsG.Pu-pp......SW-sLspGLouLslSlGTNpss	.....................MD.P.QKhNPs..scS.....S.MsstEsSp-ssusSQP.hSEpLhhsLSsLo...sPusp.s.sP..LsEuLLppphRpc.....cohpE+hhE+lt....F.pR+hthLtpVcRc+hs+Mtsa......tlt+...........ct...+hs.h...s-..+spp...FRCpCpYCpupt.........................W-......su.shplGsspss...................	0	2	2	3
+15409	PF15550	Draxin		Draxin	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NBI3	Family	This family of proteins inhibit Wnt signaling and act as chemorepulsive axon guidance molecules [1-2].	27.00	27.00	33.60	33.60	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.44	0.70	-4.77	10	51	2012-10-05 13:15:45	2012-10-05 14:15:45	1	2	36	0	31	52	0	272.10	61	88.17	NEW	tpshssNshppppPththspusHp...........+RpGhuKKcRusGhhu..t.thssscsss-uoslpuLssVtLEt.tP...uuLhp..cK-sahGhchP.stR-Np.sG.pc..+s+K+uR-H++..........sRRD+lRpp+Gc...stP..SSlh...Kcscs.EDth.ss..............s-ssosluPslh.hoshtss.shoEcsssLPssSs+PQh..u.Rs+ssGDVMPTLDMALFDWTDYEDhKP.-hWPSuKK..KEK+RSKshSsGNpTosA-s.EPCDHHLDCLPGSCCDLRcHlCKPHNRGLNNKCaDDCMCpEGLRCYAKFHRpRRVTRRKGRCV-PEolNuDQGoFIsV	......sps.PEN+lsh.tPtLapspuuHH...........+R+G.uKKcpusGhsu..t.ptssspss+puotLstht..h.tp.uP...AuLhQ..cK-lhLGhthPasE+ENpsPG..E...+s+K+uREH+R...........RRDRL+hHRG+shstuP..SSLh...KKsEhsEsth.su............shpEuSTSLAPThhaLToh-su.suTEEs.lLPsTShpPQt....psRsDGEVMPTLDMALFDWTDYEDLKP.-sWPSAKK..KEK++uK..sSsGNETSsAEG.EPCDHH.DCLPGoCCDLREHlCpPHNRGLNNKCFDDCMChEGLRCYAKFHRNR.RVTRRKGRCVEPEoANGDQGSFINV..............	0	2	5	12
+15410	PF15551	DUF4656		Domain of unknown function (DUF4656)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NAX2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 286 and 398 amino acids in length.	27.00	27.00	37.50	37.50	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.31	0.70	-5.27	3	51	2012-10-05 13:20:37	2012-10-05 14:20:37	1	2	35	0	29	42	0	317.30	55	90.92	NEW	sh+cuuQPPssRpTRRP.sPKDPGt+tPESITFISGSAEsPPEsPACC.LsRPWVWshCKAVFCFR+CRuClQRCGuC.VRuC-sCLuusssPEuhuEtuWuKEHNGsPP..SPshAPPSRRcGpRLKsTs..GSSFSYPDVKLKGIPVYRYRsuhuPusDsDSCsKEPsAEsPPhRaSLPuTLuuS...PRSSE.EYYSFHESDLDLPELS..SGSMSSREIDVLIFKKLTELFSlHQIDELAKCTSDTVFLEKTuKISDLISSITQDYHLDEQDAECRLVRGIIRISTRKSRoRPu..TsEGRpoRsutsuGsAPDSGsDTMluSVL.SQDDLsVQISQETTSDAIAR+LRPYGTPGYPsSHDSSFQGTETDSSGAPLLQVYC	.......................................................cp.sQPPssR+TRRs..DPKDPGt+GPESITFISGSAE.sss.Es.PsCC..hpshsWshC+AsFC......Cl.pCGsC.h+uCssCLuss..-ss..Ests-tshsc-H..NGh.Ps..SPspusPsc+c..upc...hKp.sh....GSSFSYPDVKLKGIPVY.Y..s.u.h.DsDSCsKEPlscssPhRpSlss.ThssS...PRuSE.EYYSFHESD.LDlPEhu..SGSMSSREIDVLIFKKLTELFSlHQIDELAKCTSDTVFLEKTuKISDLIsSITQDYpLDEQDAEsRLVRGIIRISTRKSRsRPp.....sspG.ppp+.tutssusAPDSGpETMlsSsL.SQD-..LsVQISpETTADslARphR..sau....ssGhPhu+DS.SaQsT-TD.SSGAPLLpVYC.........................................................................	0	2	5	12
+15411	PF15552	DUF4657		Domain of unknown function (DUF4657)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NAV2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.	27.00	27.00	27.60	27.00	19.10	18.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.99	0.70	-5.13	14	41	2012-10-05 13:34:09	2012-10-05 14:34:09	1	1	27	0	22	38	0	262.30	55	77.22	NEW	MuVGDSsLAs.PGLSQDSLshEPsGSP........EPPApluRLLAS+KLEQVLERS+pLPouPASLStpppshp..uKPcsEhslhuAGcQEuTcAEo-LEAGLEEuEVV......tGhtP-AWACLPGQGLRYLEHLCLVLEQMARLQQLaLQLQoQRP.tDPEEEEp......slAPuPsPS+sPGspVpGshEhLSQTccT.GuKsAuPsKVGsPSssPPRLsEAPsEPAHohPSSQGHKpDLSHWsKVKVLLNRIRWRSP+pPEPsAPPs..Gs.uPRhESR-.LPE+P.spshRKTFMPSLVVKKQR.AKNLSV	..........................................................................MsVGDSsLAs.PGLSQDSLshEssGSs........EPPAplsRhLASpKLtQVLERS+pLPssPsolStpppshp..sKPcpEhPlhuAGpQEuhcA-o-LEAGLEE.EsV......uuLsPtAWACLPGQGLRYLEHLCLVLEQMARLQQLYLQLphQRPPsDPtEEEp.........shAP.PsP.+sPGstspsPhELLSQTcp......T.GAcuAuPPKVtlPoANPPRLsEsPsEPsaphPSSQGHKpDhSHWsKVKVLLNRIphRS.+tPEPsAsPD..Gs.sPRh-S+c.LPE+P.spshRKTFMPSLVVKKQRAKshs.....................	0	2	3	5
+15412	PF15553	TEX19		Testis-expressed protein 19	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NA77	Family	This family of proteins is expressed in testis [1].	27.00	27.00	61.40	41.80	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.24	0.71	-4.37	12	30	2012-10-05 13:48:42	2012-10-05 14:48:42	1	2	17	0	16	24	0	142.80	58	56.18	NEW	MCPPVShRastEGMSYLasSWhYpLQHGsQLplCFuCFKuAFL-lK-hLE.EDW.....E-E-WDsE.ME.hoEAtsEQtussG..t.uW.GpG.hp.spusS.shGsGsLssus.t.p-..hs.phVPTELtPQ-AVPLuLGsEDADWTQuLPWRhsslPsCoHWPo	..........MCPPVShRattEGMSYLYuSWhYQLQHGsQLplCFsCFKAAFL-hKchLE.EDW..........E--sWDsE.ME.hoEAtu...........EQtu..ssG....t.uW.Gpu.GpsspusS.uhGsGsLssus.s.E-h.LssphVPTELtPQ-AVPLuLGsEDADWTQuLPWRF-GLssCSHWPo...	0	1	1	2
+15413	PF15554	FSIP1		FSIP1 family	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NA03	Family	\N	27.00	27.00	30.80	28.00	24.90	23.10	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.61	0.70	-5.66	19	68	2012-10-05 14:32:29	2012-10-05 15:32:29	1	4	46	0	43	69	0	301.10	34	73.22	NEW	DIIKGsLDuIS+PASs....SRs+PuS.RsSsu..............SLEVLoPEP...s.........htl-o.s.p.susc-................spopssssEccR.........spts.p....tt............p..phsccupD-chshsppph.sppoc-.c...........c...phDspLpcAIcKM++LD+ILs+K....h+EKEVK+QGlEh+hKLWEE.Lp.php....ppshpSsEEhcNT+KFLuLTsssppss.....ph..p.pssahsVFtTQ.....lPs-c...hEpphpphtp.chTtssppscShh+sc+p.hspppp.ch....................K+sQDFIKRNIELAKsuss.lsMhDcEK+RLtELLcDlD-tsushssspu.Dp.sshLlPGcGYT.ss.spppQLAEIDoKLQp.lssss.th...oShs.sthpspssQ....cs.hppp.psschsPGE+lLRsTKEpRD.QppRL+EI-pcLcchcEs	..............................................h.cGs.c.h.p.tts........stp.R..................slEhLss-s................hp....t.p.tpp...................tpsppp.tEppp..................s..........................hscptpcpp.sh.ptph.sttscp.c..............tphDsplpcAIpKMc+LDpILsc+....h+EKElK+psh-h+h+LWc-.lp.t......ttt.t.pcp.tNTppFLuLss..tt...........p.ptsh.slF.TQ............ls.pp....ctt.pt....s.ohcsptscuhhcst+p.hppppt.p.t..................t++spDFIKRNI...........E...........LAcputp.l.sMh-cEKcRL.ELL+Dl--tsss.sstpu........s..sshlssspGYs.ss.sppppLAEI-.KLQp..hssts.h.....s.s.st.tpp.sp.............................t.....p.tt.p.tsG-plL+ssKcpR-..ppRL+cI-ppLp.hpc.........................................	0	11	17	27
+15414	PF15555	DUF4658		Domain of unknown function (DUF4658)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8N912	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 161 amino acids in length.	27.00	27.00	88.90	88.90	22.20	20.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.60	0.71	-4.27	9	27	2012-10-05 14:35:39	2012-10-05 15:35:39	1	1	19	0	12	30	0	122.60	61	69.82	NEW	hsRAtREssR+CPsSILRRS.sE+ps.GsEPQRToRRVRFREP.EVAVHYIAsRssT..sTspu....PuRPRP+tGSLLLRLoVClLLllALGLYCGRAKPlAhALEDLRApLLsLlLRLpHsALoCW+sLLpL	......sRApREssRKCPPSIL+RSpPE++pstAEPQRTSRRVRFREP.tVsVHYIAs+ssT..uTl+s..........PuRP.R...P+G..........GSLLLpLslClLLslALGLYCGRAKPVAtALEDLRApLLsLlL+LhHsALoCW+sLLpL.....	0	1	1	1
+15415	PF15556	Zwint		ZW10 interactor	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95229	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.	27.00	27.00	81.60	61.20	24.20	23.30	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.82	0.70	-5.13	8	45	2012-10-05 14:41:10	2012-10-05 15:41:10	1	2	23	0	17	49	0	188.50	66	88.54	NEW	QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDssQGLDPLASEDTSRQKAlAAKEQWKELKATYQEHVEAIouuLTQALs+hEEAQRKRsQLQEALEQLQAKKQVAMEKhRsAQKQWQLQQEKHLQHLAEVSAEVRcRQoGsQQELEpLhQELGsLKQQAGQERDKLQRHQTFLQLLYTLQGK.LFP....EAEAEhPQ......L-LPEDK....sQ..TpPQEQ......NTGDTMGRDtuVopKAsG.hQPAGDsoLP	....QEEAELPApILsEFVhDSpKKDKLLCSQLQVVDFLQNhLAQEDTs.puLDPLASEDTSRQKAlsAKEQWKELKATYpEHVEAIphuLTpALsphEEAQRK+sQLQEAhEQLQAKKQhAhEKh+hAQpQWQLQQEK+L....QpLAcsSAEV+pRpptsppcLpt..QcLtsLpQQAtpcp-KLQR.QoaLQLLhoLQuK..hsEu-sEh.......................................................................................................	0	1	1	3
+15416	PF15557	CAF1-p150_N		CAF1 complex subunit p150, region binding to PCNA	Coggill P	pcc	manual	Domain	CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork [1,2].	25.00	25.00	37.10	34.40	21.00	16.10	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.54	0.70	-5.02	4	49	2012-10-05 14:44:19	2012-10-05 15:44:19	1	4	31	1	24	45	0	203.20	44	23.92	NEW	MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTSVQSKSPDLEASLDTLENNCHsGSDIDFRsKLVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPSREAlNG...QREDTGDQQGLLKAIQNDKLAFPGETLSDIPCKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAG	................................hAM-CKD+suhP..sKKLlQARLPFKRLNhVPKEK..s-......-t..u..-..s.....p.........s....s.S.....spS...psPD...L-...s...S...L..DsLENcCchuSDlcFpPKLVNGKGPLDsFL.pp.cl.csSl.upo..hVIIDLTEDSN..-p.s..........Du....scHscL.socASsup.cslNG....tpcstsp.u...pu.ppsphs..tET.oslPscsctt..s.t....tpp..s.t.u..shP.L....p.....t..sWSt................................................	0	1	3	9
+15417	PF15558	DUF4659		Domain of unknown function (DUF4659)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8N715	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.	27.00	27.00	32.50	31.10	25.50	26.70	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.45	0.70	-5.80	21	78	2012-10-05 14:49:01	2012-10-05 15:49:01	1	2	41	0	48	66	0	313.20	35	59.61	NEW	tslPpRD+KIsALMLuRhcctphhpE.pptAthtWEp.++p-pph+.p.E+E+phtLtQupctWppphEpR+s+h.........spEp+sptccppppsh......pE.p+W+ctsEcQEp.Rp-+l-+s..phpscp+KppQEppL+ppEchtpsh+Eppp.hthpc+hppAspK+ph+p.hptQ+clptpNh.uphlpHpAhKhhl-pQp+sEc.hh+hSLEpphp+uQEsappLlccRs+EL+EKApKE-pQhp+A+htAEcpEc.p+pc+hcsLsclu-pKlppApphuccsspcKAp+ltp.ph.+E+sp+l.KpKlEcEEcs+hctlppuIc+K-pRsEQIp+EKcsslEpuRplARAShpsR-+l+p.htspoFD+MAhEApLpAshpct	..........h.slspRDpKIsALhLsRhpctphhtE.pttAthtWEp.+tpspphp.p.E+E+phhLtpupctWptph-pR+sp..........s.Epctttccpppp........sEpch+t.s-cQp..Rtp+h-cs..ttpsch+K.pQ.ppL+ppEchhpphREptp...hpc+htpAspp+phpt.hphQ+chpphNh.uphhpapAhh.hhspQtctEc.hh+hSLEtshtRuQ...E.aptLh.cpRp+EL+E+...Ap+E-.QhppA+.tAccpEc.pppt+hchLschu-p+lppApphsccssppKsp+ltp.ph.+E+sp+h.K.KsEc-Ecs+hctlhpuIt+K.pRscplpcp+csshpphpphupAShp.+ctsht....pohDphshEApl.Ap.tt...........	0	9	14	23
+15418	PF15559	DUF4660		Domain of unknown function (DUF4660)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8N6N3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 189 amino acids in length.	27.00	27.00	32.20	31.90	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.14	0.72	-10.72	0.72	-3.97	14	53	2012-10-05 14:52:51	2012-10-05 15:52:51	1	1	37	0	28	47	0	103.20	61	53.36	NEW	SSDS-scupscpppt..ts.sssssSsupsttt.........hLPcPDELF+SVS+.PAFLYNPLNKp...IDWE...s+......sl+APEEPsKE......FKsWKTNAVPPPEoYssc..-pK......ssPPuhDMAIK	......SSspE.DssEPE-ssp+sss..supuuG..Gptspuc.......tRLPGPDELFRSVoR.PAFLYNPLNKQ...IDWE...RH......VVKAPEEPPKE......FKlWKoNhVPPPEoYosE....KK.....PPPPthDMAIK....	0	5	7	13
+15419	PF15560	Imm8		Immunity protein 8	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and several conserved charged and hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family [1]. The protein is also found in heterogeneous polyimmunity loci.
	25.00	25.00	154.00	153.80	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.40	0.71	-4.49	7	13	2012-10-05 15:01:24	2012-10-05 16:01:24	1	1	12	0	1	11	0	133.00	45	92.86	NEW	MElhlssVlGGplssp....+slpsllhcMRKplKcpFtshphEuLs+hKIslahSGDlSpYsspoGIhpsRYapcKKEalspFCID+phWoup.h.Dlp.KFLhhlps.hlpLGslI+pKLcptsYsFDschaK-hl	MElslshVhGGplssp....KslpshlhpMRK.lKcoFpsh-.EulsphKlsLahsGDlSSYhspTGIYQsRYastKKEalspFCIDRspWousKhcDls.hFlhhlpshhIchGsLIcpKLtKhpYsFDhpsYKchV..	0	1	1	1
+15420	PF15561	Imm9		Immunity protein 9	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and several conserved polar and hydrophobic residues. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1]. 
	25.00	25.00	34.30	33.70	21.70	21.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.86	0.71	-4.64	5	11	2012-10-05 15:02:01	2012-10-05 16:02:01	1	1	10	0	1	10	0	140.10	38	90.75	NEW	KIlTspt.......hcEIpchlc.+sstFEEIPIIoRasRtchLp+sIu+E-lslaLLNlALFaLNNIpLaA+clLsp.psssLFICITlVD...lE-EhsDl.GFsIPNILIS+cK.htsplppcstlNL-cpcaLpcphupluhpshFphY+opoDDGaGt-IhRIYllPK	..Kl.+shQ.cpI.phlt.hsstFEEIPIIophtR.chhhcshu+c-hslhhLNsuLFhLsNlpLhs+clLspppppsLFhCIThss....p..hsDl.GF.lPNIhISppt.hhphhppt.thslcp..aLpp.hppluh.shFthhhshosDsaG.-hhRlallsK................	0	0	0	0
+15421	PF15562	Imm10		Immunity protein 10	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with two transmembrane helices, and a WxW motif and a conserved arginine between the two helices. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1]. 
	25.00	25.00	27.00	26.70	24.40	23.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.14	0.72	-4.21	46	149	2012-10-05 15:02:37	2012-10-05 16:02:37	1	2	105	0	21	102	0	59.30	30	73.33	NEW	llhlhlGllhLluuIhsWcWhhssp.ss......ph.....hl.chhGcpshRlhh.ul.lulllIhsulhha	....lhlhlGllhLluulhsWc.Wh..asspss......ph.....hl.cphG+pttRlhh.ul.LGlllIshulahF......	0	4	16	18
+15422	PF15563	Imm11		Immunity protein 11	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved HxxRN motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1]. 
	25.00	25.00	65.90	65.60	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.53	0.70	-5.25	3	9	2012-10-05 15:03:45	2012-10-05 16:03:45	1	1	9	0	2	8	0	221.80	47	96.85	NEW	MN+IpshEhshSNshFWNFhhsaa.RGaDEE+EsNlDEVh-......lVEscchKuY.W..sWFsQlDlKTsEsttElE..NPRTlshPIsDDlsaslEFHPsEThYFlNDTYIGNlGGHFHLpaLTaoELhuI..pcEKYuSLLFaLLLPLTuIcEsEKsIl+sEIspHLpcIPlFKsHSsYIuDC..ILNGLllu-SsFQppcGIGhlsspNHShRNthsY---+csIpELN+LLV+	.MNhIpphEhshSNshFW.Nhhhpaa.cuaDEE+DsNhDEVh-......ll-pcchKpY.W..sWlsQlDlK....TsEspGEIE..NPRTlsLPIssDlsholEFHPssThYFLNDThIGpluGsFHL+aLTaoELhcI..TcEKYuslLFaLLLPLouI+EpEKshhhstIhp+LppIPlFKpHSsYIucC..ILNGLllusSshQph.tIGhlsspNHShRNthhY---+ppIpELNhLLs+...	1	1	1	2
+15423	PF15564	Imm13		Immunity protein 13	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in heterogeneous polyimmunity loci of polymorphic toxin systems [1]
	25.00	25.00	235.30	235.00	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.69	0.71	-4.44	2	3	2012-10-05 15:04:31	2012-10-05 16:04:31	1	1	3	0	0	3	0	131.00	66	79.39	NEW	.ps-FtSVlsEFtpLls-asFpCPcKLWYssLlsLSKpl.DIYYCYlIsRVYKpsGSLEsThWVGsIsRPDDGLENLSANIKhQIGYsQshD.hFF+pCESKIl.lIESG.LhsLlssSQ.EhKh.ShHNh	..oDDF+SVVAEFGNLINDFGFSCPEKLWYsNLISLSKNVcDIYYCYVIARVYKsDGSLETTLWVGPINRPDDGLENLSANIKIQIGYTQVsDPLFFRNCESKIIsLIESGILKTLLssSQNELKaPSIHNh.	0	0	0	0
+15425	PF15565	Imm16		Immunity protein 16	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly alpha-helical fold and a conserved DxG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-SHH family of HNH/Endonuclease VII fold nucleases [1].
	23.00	23.00	23.00	24.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.30	0.72	-4.18	6	55	2012-10-05 15:06:40	2012-10-05 16:06:40	1	1	47	0	13	56	0	98.40	38	65.46	NEW	ccLhuscphtsQs-CccF.ullcAlpcpl-tcllcsLLpTFuDc.cDa.GlQ-plVpVl-ps-sphahsclstthsplh-pAs.+EWAhhLlGRllNSsstcpthttlh	....................Lhp.Rhhcsp.p-.h.c.FppsLtclhphsssplIs-LCllh-D-.....pp......-VMFsLlahlE...p.....th...-ct...LhplsculP+MlpsA...EWsclLahRILNscthR.tYscl.h.........	0	0	5	7
+15426	PF15566	Imm18		Immunity protein 18	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved histidine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox12 or Ntox37 or Notx 7 families [1].
	25.00	25.00	51.80	51.40	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.63	0.72	-4.63	9	13	2012-10-05 15:10:02	2012-10-05 16:10:02	1	1	13	0	6	12	0	52.50	36	65.01	NEW	tcGLthLhcpLppLps+.....spHhHLMTsuWuGsELo....-ppQupcs.pLlsHl+l	..-GLchLtcplppLtp+.....scHhHLMTPuWGG-ELo....EccQup-s.pLlpHl+l.	0	3	4	4
+15427	PF15567	Imm19		Immunity protein 19	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a protease domain such as Tox-PL1 and Ntox40. In some instances, it is also fused to a papain-like toxin, ADP-ribosyl glycohydrolase and a S8-like peptidase [1]. Based on these associations the domain is likely to be a protease inhibitor.
	25.00	25.00	31.20	30.50	23.40	22.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.87	0.72	-3.98	20	224	2012-10-05 15:12:48	2012-10-05 16:12:48	1	6	217	0	16	64	2	85.00	73	70.53	NEW	hccAhtpAppaLpt....ss-hs.........lll..ststchshGWlFsasotcaLcoGD.tspLsusuPllVc+ssGclt.........shusspP..htcalpcacspt	.................Y.HDAFAKANHYLD.....DADLP.......VVI..TLHGRFSQGW..YFCFEAREFLETGDEAARLAGNAPFIIDKDSGEIH.........SLGTAKP..LEEYLQDYEIKK............	0	8	11	13
+15428	PF15568	Imm20		Immunity protein 20	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved GR, and GxK motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family of nucleases [1].
	25.00	25.00	43.50	43.50	24.40	19.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.48	0.71	-4.25	2	3	2012-10-05 15:13:23	2012-10-05 16:13:23	1	1	3	0	1	5	0	96.70	50	94.16	NEW	MAcpRhhl.GGVuLhhGRV+pu..shh..pDclE.hL.D.sFhp-hPFKhluhlhhaGpKs.LhPpY-.INK+au-LPltlELchthLchAsp...-llhshFhhusl-sLlcVucKYtLPst.Lcp.suh	MAHNRKYVPGGVALVMGRVRNS..GKVVEQDElE.hL.D.sFhp-hPFKhluhlhhaGpKs.LhPpY-.INK+au-LPltlELchthLchAsp...-llhshFhhusl-sLlcVucKYtLPst.Lcp.suh...	0	0	0	0
+15429	PF15569	Imm21		Immunity protein 21	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved phenylalanine and tryptophan residues and a GGD motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox19 family [1].
	22.20	22.20	24.20	24.20	20.30	17.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.12	0.72	-4.21	11	48	2012-10-05 15:14:00	2012-10-05 16:14:00	1	1	45	0	6	26	0	84.30	53	77.70	NEW	sLt.lGltphAashpDsLchlshhcppphsILGGDVYphpsstlclTYDuWaas...cpss-sshp...psh.hAh-YIspYhs..psup.phlasl	.......s.LhulGIcEsAhPlshAIDILNLalsERILVLGGDIY.IKKDN..YFYQTYDNWYYE...GSNLFNSI-.......KAMHYLSQlKhENAYVSFV...Lph..............	0	3	6	6
+15430	PF15570	Imm24		Immunity protein 24	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold with conserved tryptophan, proline, aspartate, serine and arginine residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-AHH family of HNH/Endonuclease VII fold nucleases [1]. The gene for this toxin is also found in heterogeneous polyimmunity loci.
	23.40	23.40	24.10	27.00	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.69	0.71	-4.39	11	23	2012-10-05 15:15:18	2012-10-05 16:15:18	1	1	15	0	11	23	0	119.60	29	55.27	NEW	hshpW.......aphs.stphs.......p.....hPppLa.lCs++hctLpFDah..as.shaIlS-cFlchlpchphspphptshlplss+cGc.pls.cchYYhlRhhahsp-.F...ctSph.pp-hpcsh...........l..Y.clpL+-ps.	....h.phpW.......apspstth........phPspLYhlCsKKsttLpFDah..as.phhIlS-cFLchlpc.shsccashupltlls+Ksc..ls.cchYYhlRl.ahsp-.Fh..ct.ph.pp-hpcpl...........l..Y.chpL+-psh......................................	0	0	7	11
+15431	PF15571	Imm25		Immunity protein 25	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1, Tox-URI2 or Tox-ParBL1 families [1]. The gene for this toxin is also found in heterogeneous polyimmunity loci that show variations in structure even between closely related strains.
	25.00	25.00	27.10	27.00	23.00	22.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.81	0.71	-4.01	3	30	2012-10-05 15:15:50	2012-10-05 16:15:50	1	1	30	0	3	20	0	125.40	37	95.19	NEW	MKaFIGGEIE....psIsDKFR+sRNsV.....I-aLDsL.GscIpSINElSFhVas.LKcFphsPlo+YpKKpNRlELEIhI-F-pFEsANDspssELLKQsILAVIpcYcNKsI.psSlDlIhoKlEsEIpp	.M+hFloGELE....psIu-c....FRcsRspl..........hch..ssh.ts-l.ppIs..lshhVhh..hKpap....t.pEhphap+Kppch-hRLhI-a-pF.oANDSppspLllpsIlpuIcpht...sKs..pp.h-s...KhctsI.......................	0	1	3	3
+15432	PF15572	Imm26		Immunity protein 26	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved C-terminal tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-ColE3 family [1].
	25.00	25.00	26.70	26.50	22.20	18.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.12	0.72	-3.86	19	24	2012-10-05 15:16:50	2012-10-05 16:16:50	1	3	21	0	11	26	0	95.40	35	75.88	NEW	hKLl-apschlpRGslhRhsut...............aPaE.clVDFMVh-h.s..tt....shuLllsSGaKAGhlh.hhhPpEuhsppst..ulSTpWllcNWp+WlYscCslccVal	.....+Ll-atschlpRGslhRhsuh...............aPa-.plVDFMVh-t.s.tt....shuLllsSGaKAGhlh.hhhPpEuhsppsh..ulSopWllpNWp+alYspsssccVhl....	0	2	8	10
+15433	PF15573	Imm27		Immunity protein 27	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved KxGDxxK motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1].
	25.00	25.00	26.20	101.60	23.80	18.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.50	0.70	-5.18	10	46	2012-10-05 15:17:35	2012-10-05 16:17:35	1	1	40	0	5	43	0	234.00	55	96.89	NEW	sLhsuIWaG-loshols-LKpsLLsspTE+EsllLIlELhKtGDFoVKsLLIpLMNpTcDEsVLNLCIRLFCSVuTHDDL+-oNNL+FLusASEhuVaTFsuuAlsTLSYEVIPYLLsLLEEWE-..oDlEhuIRDuLDhFLNacspluE-ATlEElGshYh-hlcspDhspYYY+ssLAFPGDLTKcLhpclhlAAp+EEpa+hhlIPSLLSIaTGEKVPlDhcTIIoscch+chlsYIDsLocKsWccGpKYFYGahV	..LhpsIWaG-ho.hshpplKpplhcusTEpEslh.lhELhKtGDFo.KsLLlpLMNpT+DEsVLNLCIRlFhSVATH-DLc-oNNL+FLSpsoE-sVcTFsuuAssoLShEVIPYLLALLEEWE-..o-stphIRDulD.alsacDpluE-Aol-ElGphYhcaspppDsppYYapppLuFPGDLsKclhpcVMhAApsccphph.lIPSLLSIWoGh+sPh-YsTIIospph+-hhsYIs.LopcpWccGpKYFYGahl.....	0	1	4	4
+15434	PF15574	Imm28		Immunity protein 28	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an all alpha-helical fold and a conserved HRG motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1].
	25.00	25.00	70.50	70.40	22.30	18.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.59	0.71	-4.56	8	15	2012-10-05 15:18:14	2012-10-05 16:18:14	1	1	15	0	0	16	0	117.70	43	93.88	NEW	alsEuhphsschlphlpl..DlpDE......hpRQlluuYlFGhLNuLAh-cshsPsDlQusMIclhIcpLsYsspsAsphspFlIcuTDKpFHPThaAIIHRGlEGYahYp-c.+.s-LpcDFp-IlpllK	..lsEulchlschlpllpl..DlpD-......h-+QllAuYlFGMLNGhAa-csIsPsDlQuhMIcIuI-KLsYosEsAsQhoQFlIcuTD+pFHPThaAIIHRGlEGYahYp-p.c.ppLpcDFp-IlpllK.	0	0	0	0
+15435	PF15575	Imm29		Immunity protein 29	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an all alpha-helical fold and a conserved proline residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-REAse-1 or Tox-REase-6 families [1].
	26.00	26.00	26.00	26.30	25.30	25.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.29	0.70	-4.73	81	217	2012-10-05 15:19:04	2012-10-05 16:19:04	1	2	129	0	57	210	3	198.40	19	70.51	NEW	csshsph...cphthhssthphhsshhtsst...........................h............h...s.t.hhs...sts........Wh..ssh..hhAllscspp.hhshLsphss.........ph.hppstsths..............hshshhttLpshhhsps......shhcplhpthp..tsts.....................phhpthhh.s.hphahslh...p.pDpssappuLtptLph+pthhttpcttt............sscs...........hlshhsluhAplAacp.G.....hplpl-SsYlPppLl	...................................................................tth.hh.sththht.h...t..............................................s.....hs...hhs........h...ssh...ahslhscs.p..hhchLsph.s.........sh.hppspshhs.............thshshhhhhpshhhsps......t.hccLhpphpts.hs.............ts..tchhpphhh...hchhhuls...p..pDtpshctuLpthlch+pthhttpcp.p............hhct...........alshtllshAplAhpp.G.....hplsl-sthlPptLl................................	0	11	28	42
+15436	PF15576	DUF4661		Domain of unknown function (DUF4661)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95873	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 281 and 302 amino acids in length.	27.00	27.00	56.40	29.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.68	0.70	-4.73	7	26	2012-10-05 15:20:41	2012-10-05 16:20:41	1	2	20	0	13	29	0	232.20	69	83.25	NEW	RRKss+PD.ssPEsRhhDSSPENSGSDWDSAPETMGDsGPPKsKDSGsp+ssGsAPE.SR....csps-QLGS+RMDShKhspsssshpEStRLEAuGslsplGpDPhsusGshc.tVs.Etthss.GPEAPVEKsuR+Q+LLGWLpGEs....GAPspYLGsPEEhLQISTNLTLHLLELLASALLuLCSRPLRAsLDALGLRGPLGLWLHGLLSFLAALHGLHAVLSLLTAHPLHFACLFGLLQALVLAVSLREP	.............RRKsh+PD.PsPEPRplDSSsENSGSDWDSAPETMGDVG.PKTKDSGshRsStAAsEPS+....EspVEQLGS+RMDSLKh-pssSsTQESGRLEAGGA.P+LGhD.VDSuGs++sGVSPEGshSsPGPtAPlEKPGRRpKLLGWLRGEP....GAPspYLGG..PEEsLQISTNLTLHLLELLASALLuLCSRPLRAALDsLGLRGPLGLWLHGLLSFLAALHGLHAVLSLLTAHPLHFACLFGLLQALVLAVSLREP...........	0	1	1	1
+15437	PF15577	Spc7_C2		Spc7_C2	Coggill P	pcc	manual	Family	Spc7_C2 is a short family to the C-terminus of fungal Spc7 proteins. The Ndc80-MIND-Spc7 complex plays a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle [1]. The N-terminal region of Spc7 co-localises with the mitotic spindle, and it has been argued that Spc7 has the potential to associate with spindle microtubules and that this association is regulated by the C-terminal part of the Spc7 protein [2,3]. However, this family represents only the conserved region towards the end of the C-terminus; the majority of the C-terminal part is in family Spc7, Pfam:PF08317.	22.30	22.30	24.00	22.90	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.70	0.72	-4.32	16	47	2012-10-05 16:37:54	2012-10-05 17:37:54	1	7	47	0	42	48	0	66.50	29	5.52	NEW	hchLs.lpptWspuphlsp-l+tlphpaP.ssssc.so.Dpolplpss.lhlsslco+Vclshslst.pltp	.....t.plLphVpsuWspAptlsppl+hlshsaPTsls.......c.oS..Dsol...sls....uS.lLLsslpT+VclshsLpt.....p........	0	10	26	37
+15438	PF15578	DUF4662		Domain of unknown function (DUF4662)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95567	Family	This family of proteins is found in eukaryotes. Proteins in this family are approximately 290 amino acids in length.	27.00	27.00	201.10	200.90	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.76	0.70	-4.81	8	21	2012-10-05 16:38:14	2012-10-05 17:38:14	1	1	20	0	13	24	0	259.30	75	91.71	NEW	HPIYVRR-PSIPTYGLRQSILLNTRLQDCYVDSPALTNIWsuRTCAcpNIpAPsPGTTSSWEVVKNPLIoSSFSLVKLVLRRQLKDKCCPlPsKFG.EAKspK..RLKsKDsSssKAT.puRhRNSIssKSKpPuGQhPG..SscpR+PAGulpESKESSKEKK.uTVsQDLE-RYAEHVAATQuLPpDotTAAWKGQA.LPETpKRQpLSEDsLTIHGLPsEuY+ALYHuVVEPMLWNPSGTPKRYSLELGKAIKQKLWEALCSQAAsPEsAQcD	............HPI.VRRDPSIPhYGLRQSILLNTRLQDCYVDSPALTNIWhARTCAKQNIsAPAPuTTSSWEVV+NPLIASSFSLVKLVLRRQ.LKsKCCPsPpKFG.EuK.SK..RLKpKDsSshKATQpuRhRNSISSKSKpPAGp.........RRPAGGIpESKESSKEKK.lTVRQDLEDRYAEHVAATQALPpDSGTAAWKGpsLLPETpKRQQLSEDTLTIHGLPTEGYpALYHAVVEPMLWNPSGTPKRYSLELGKAIKQKLWEALCSQuAhsEGAQ+D..	0	1	1	1
+15439	PF15579	Imm32		Immunity protein 32	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved tryptophan and phenylalanine residues, and a GT motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-REase-5 family [1].	25.00	25.00	36.10	35.90	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.24	0.72	-4.45	36	138	2012-10-05 19:59:56	2012-10-05 20:59:56	1	1	70	0	44	152	0	95.40	43	46.47	NEW	hpllpsls.ttasshalplsspsY..hpcpVF.sD+suVGWMLYLP+hITtpQVPEApsLlPV.ssscp..pGTIIVS.TDtsFoscNsEHlchANcIEIRLlDtsLL	....................h..hlpshh..hhps.hh.sssptY....hpcplF.sD+.uVGWMlYLP+hloppQVPEAcALIsVss.....t.....scp..pGTIIVS.TDsPFoscNPEHVtlAN+IEIRLlDtsLL.	0	4	9	25
+15440	PF15580	Imm33		Immunity protein 33	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved tryptophan, and WE and PGW motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox24 or Ntox10 families [1].	25.00	25.00	60.60	59.90	21.40	19.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.18	0.72	-4.50	33	42	2012-10-05 20:00:33	2012-10-05 21:00:33	1	2	40	0	18	47	1	89.90	36	81.91	NEW	lpWLpcWYtspCDG-WEHpaGlcIsTLDNPGWplpIDLscTshpshpht.lplcps..........c.sDWhtsplcssp.....FpusuustpLpclLphF+pWl	..lpaLQsWYtspCDG-WEHpaGlpIsTLDNPGWplpIDlspTshttpthtplplcps..........c.sDWhtsplcstp.......FpuhsusppLpclLphFhpW...........	0	7	12	16
+15441	PF15581	Imm35		Immunity protein 35	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and YxxxD, WxG, KxxxE motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene [1].	25.00	25.00	137.30	137.10	21.80	19.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.04	0.72	-3.97	4	5	2012-10-05 20:01:14	2012-10-05 21:01:14	1	1	5	0	3	5	0	93.00	41	86.43	NEW	l.sslhhAYhhlD+SIoLoYhpQuhEoucuslcsLppLIEcEWRGLsptQVh+KLcsVAtppsttchVlK+..EsslIWF-pVRFpFspGRLspV	VssslhFAYhWIDRSISLSYucQGpETAcuoV+sLppLIE+EWRGLPEsQVh+KLcAVAApustu+IVVKK..EGslIWFD-VRFNF--GRLcSV	0	1	3	3
+15442	PF15582	Imm40		Immunity protein 40	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved YxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-JAB1 family [1]. The immunity protein typically contains a signal peptide and a lipobox.	25.00	25.00	33.10	32.00	18.90	17.60	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.17	0.70	-5.73	2	16	2012-10-05 20:02:21	2012-10-05 21:02:21	1	1	13	0	1	14	0	222.90	40	87.58	NEW	lpQtVttQsclLlDSGhlhspYl.l.Elh.sDSNplY.IttuDsPus.thEhPS+lIKYK-+YLCFIELDEs.MStpEhhEt.....SsaptNLslp..tG+sWLLslpKht-K+ILlch...hhh..hFphsELWsYFSG.l.ptpss.MGlhSHDl.lssSYlss.h-..hcsL.......pshlcph.Gphal+NpTDSVlhLSpsot+p..YAVlsG.DoLhLsLpDSLPlhluPp-hK.LcYcS.P.ps..Fhp.h.ccD.W..hYpLFscSTasFlNlNsh.pph+lMapD.ssYu.slp.o.sph.h.IhN+GlYDKc.t.hphF+a.	....................................................lpQtVttQsKlLlDSGhl.s.Yl.l.Elh.NDSshIY.IpsADsPus..thEhPSKllcYKs+YLCFIE.LDE..MStpEhhEt.....SsaptNLhlp....csWlLslpKhtptphLlch....ha..hFphspLW...............................................hshlpph.GphahpN.hDphhh.spsoh+p..aAVlsG.DoLhLsl.Dols........p..........................hYpLhtcSTa.hhs.psh..thpl.apD....a......t..s..h...l.pcuh..........................	0	1	1	1
+15443	PF15583	Imm41		Immunity protein 41	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved glutamate residue. The domain is often fused to one or more immunity domains in polyimmunity proteins [1]. 	25.00	25.00	30.00	39.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.92	0.71	-4.42	13	63	2012-10-05 20:02:45	2012-10-05 21:02:45	1	12	59	0	9	44	1	147.30	48	27.96	NEW	MYI-.KYWGsaIGGoDDSLsLlsYLtspc+-cIoLsEIFsDhGLDcL.....shsF+pTsp..ltap....sp-G.h-h-FcaAIDllsDLAAllLECptsGpVsLp-L.t.ss.psRhIRIsAosEEhshlspALtDFspsPhcYDLsEMhs--DhtEhApcs-pLRpEL	....MhI-.pYWGpahGsSsDShsLspYLtspc+E.lslsEIFpDhsLDcL.....shNapps............phDG.sthcFc.AhplVhDLAsLlLEsctsGphNLtcl....tss.sRhhRIsATsEEhhslshALpcFAhuP.-YcltEhhD--.-hhEhuphsEplRtpL.......	0	3	5	8
+15444	PF15584	Imm44		Immunity protein 44	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly all-beta fold and GxxE, WxDxRY motifs and a glutamate residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox48 family. This domain is often fused to the Imm71 immunity domain [1].	25.00	25.00	28.90	51.50	22.40	17.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.36	0.72	-4.13	17	44	2012-10-05 20:03:57	2012-10-05 21:03:57	1	2	19	0	19	51	0	100.50	46	32.10	NEW	sFPssLPtlP..s.stssllpSGcclPssGIWEPhss.psKl.................GChNYhltGohAPphttpsss.................pthsspWRLlWEDpRYpDGoIP-EEpsYlh	.......hFPssLPcVP...pstsslIpSGpclPC-GIWEPVshtpsKlhulhsh...spt.h..sGChNYFltsstAPphtp-sss.................t.lsspWRLLWEDcRYtDGsIP-Epphal....	0	0	0	5
+15445	PF15585	Imm46		Immunity protein 46	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved GxaG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Tox-REase-3 domain [1]. 	25.00	25.00	27.90	27.60	21.20	20.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.43	0.71	-4.09	17	27	2012-10-05 20:04:40	2012-10-05 21:04:40	1	1	21	0	9	26	0	115.60	35	94.69	NEW	MaEaHGWhTIptospppDs...tph-pllsclpphlschshs.......shlcLphhNGphhlphuGhsNH+spph.pllslappluclAPGSYGLLYh+DDE..-.....thsNpFRVahhtRGplocppDsaLSPslPhlED	........MhEaHGWholptostttDp...tp.cthhpclpthlschsh........shlsLphhNGphhlphuGhsNH+st.h.pllslappluclAPGSYGLLYh+DDE..-.....thsNpFpVhhhsRGplspppDsaLSPslPslED..	0	5	8	8
+15446	PF15586	Imm47		Immunity protein 47	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved Wea (a: aromatic) motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox7 family [1]. 	26.90	26.90	28.30	38.20	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.38	0.71	-4.26	29	121	2012-10-05 20:05:12	2012-10-05 21:05:12	1	1	87	0	25	68	1	107.40	38	93.43	NEW	+splKulpss..chs...LcsahP-csssFshhlplpIGs.pspp.Gu-.FplhlCTPcWLppphtptthh.htR+hLlVpc.Y.chcpIhshlpchlspCpupsWtclupKLuRhhtWEaEDYp	...........+lcLKshsh...DhD...hEcFsP-h.-NFphhlsLsIGh.-spp.G.ush.FplhICSPcWlpp...phpc.t..h......h...pstllhpp.a.shchIhp.IscIL-hC.sp.poW-cohspLtRaFsWEFEDYp....	0	7	14	22
+15447	PF15587	Imm48		Immunity protein 48	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved lysine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family [1]. The protein is also found in heterogeneous polyimmunity loci.	25.00	25.00	35.30	35.20	20.70	19.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.98	0.71	-4.84	7	30	2012-10-05 20:05:35	2012-10-05 21:05:35	1	1	29	0	2	21	0	153.90	43	97.65	NEW	Mc.clpl...hl..plPpL.Ehsslcsl....+.tLpsalpslhstINlpc.Ls-WpLhlhl...shhus..NtIGlaK+uppaoSsKEhphSIulslPspccshaGlsch.cpuahs.lscppFh....lLpss.FspYsNLtcYIlEsuKluIh.hhppGhphpGhKIph.	..................Mp.Qltl...LlssplspLhEhspl.pl....pc.lpsYhpDlsNtIphD-.L...sDWpLhI.l...shhss..stIGIaK+uh.pasSsKEhploIuIPlPspcpsRaGlsch.....puahs.lsccsFh....lLsss.FuKYDNLhpYIl-suKhAIhshFphGFThpGhKIKK+.	0	1	2	2
+15448	PF15588	Imm7		Immunity protein 7	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly all-beta fold and a conserved arginine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Pput_2613 deaminase domain [1]. The protein is also found in heterogeneous polyimmunity loci.
	25.00	25.00	32.80	31.90	23.80	21.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.20	0.71	-10.31	0.71	-4.05	32	42	2012-10-05 20:13:00	2012-10-05 21:13:00	1	2	40	0	14	45	1	117.50	21	78.64	NEW	.hpFpAphlsspt-sc...hhhlGhAD.cc.ssppallhQRsh....c-pDtptshsuha..sps....sstssYsslcplpLppspltlplpssshh.....slsls..plplsh........ph......hphhpphhpplLp.	...thpFpAphlssph-sc...shhlGhAD.cc.ssppYlllQRsh....--pD.p.shssha..hch...tsspssYsslccltLppsplhlplpcss.t.....slshs..plplsh........sh.......hphlpphhpplhth.........	0	5	8	12
+15449	PF15589	Imm12		Immunity protein 12	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved WxG and YxxxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the NGO1392-family of HNH/Endonuclease VII fold nucleases [1]. 
	29.00	29.00	32.50	32.20	25.70	24.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.46	17	45	2012-10-05 20:14:09	2012-10-05 21:14:09	1	1	43	0	16	45	1	144.10	33	88.74	NEW	pWVEShGGPLlsVPtosLshWsGss........s.spsssDYDRACsVDGhsGllslGs..up.....ALVLGDEPAsTsYL..PcHtsF..lRW......hAADS.....Es-Llusscssls..uspW-..spspWpss...GPsVLhDuA..........aPG.usss...sphtVsLssGRatVRAscscs-tcoh.	..........pWlcotGGPllhl.psshthWpGsp.....................s.sDYsRACsVsshlGllslss..tp.....ALVLGDEPhsTsa..l...scc..tsF..lRW......hsA-s........Es-llsuscsshs....sstWp..spsp..Wpss...GslVLFDSA..........hPssphs...spl.lsL...sGpatV+ssphpss..s..............................................	0	4	10	15
+15450	PF15590	Imm15		Immunity protein 15	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved aspartate and GGxP motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox10 or Tox-ParB families [1].	25.00	25.00	69.80	69.60	19.20	16.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.29	0.72	-4.89	5	9	2012-10-05 20:14:46	2012-10-05 21:14:46	1	2	9	0	1	8	0	69.80	37	13.46	NEW	Dsls-RIEsLIsNp..LpclAh.....pPD..uWEsLYpDPcDGRaWE+lhscSchcGGGPPpLpslSQsss+s+Ypl	..Dsls.RIcsLlsNp..Lpcluh.....pss..GWpphapDPsDGRaW.hshspSchcGGGPPpLpslSQ.ps+spYph.....	0	0	0	1
+15451	PF15591	Imm17		Immunity protein 17	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly all-beta fold and a conserved GxS motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox17 or Ntox7 families [1].
	25.00	25.00	73.40	73.30	23.10	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.27	0.72	-4.21	6	26	2012-10-05 20:15:26	2012-10-05 21:15:26	1	1	26	0	3	9	0	77.40	76	97.53	NEW	M...KhsFYp.Vclhp..ssst.....cltGc+GVVlGhSE-DsthaGYuVlIa.-hcpsh.l-cc-ltsTGphhsR--FY	..MTNLKLDFYSEVIIKDSCPNDLLENGETIKGKKGVVLGISEEDGIIYGYTILLF.DIKYCIYIDKKYIIPTGKKFSRDDFY	0	1	2	2
+15452	PF15592	Imm22		Immunity protein 22	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved SF motif and tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox21, Ntox29 or Tox-ART-RSE-like ADP-ribosyltransferase families [1].
	23.30	23.30	25.40	24.90	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.65	0.71	-3.77	13	133	2012-10-05 20:17:06	2012-10-05 21:17:06	1	1	76	0	12	78	1	110.90	58	90.11	NEW	+Nlsps.pa-EsSFIuplh-pupWscccYW+LEpsLhpl...sp...phphsc-lspplhhuhhpllshlh.thsstc.apIps..h...........cshc....I.shhERhchlhptlFs..scslcpstF.hh	............RNIPsFEcYDENSFIGKWYD.DGVWDDEEYWKLENsLIEV...R+...KYPYPMDIPRDIVIGIGTII-FLM..VsNWKLFcIKu..SP.......WLPcSVt....IpERYERh+sMLRYIFT..-hDl.NspF.Y.....................	0	5	8	9
+15453	PF15593	Imm23		Immunity protein 23	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox18 family [1].
	25.00	25.00	26.00	25.80	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.98	0.71	-4.00	26	70	2012-10-05 20:18:30	2012-10-05 21:18:30	1	1	56	0	16	50	0	150.50	23	94.87	NEW	MIaG-...P.pFulhh-h.lppWs.sss..a.....ppGhFsaaIsuchhPs.hhsso..LtssltpL..pph..........thhsthpsppLFshsstchhphl..............hphh.sphts....pt.ch.......aphhloh..shsDs...Gh.lFh..lps.s-ph+llatp.................pstslp..-hhLptsphppllppl.t	.......hhGp....pcFuIhh-p..pchs..ts..a.....h.GhhphhIssphaPp....t...hho..LssshpsL..csp..........th.pphhssthhsL-htc.thh.l...............hchsp.phss.......ph.......hshhhsss..shp..-...shslhh..hps.s-p-RLhath..................sspshc..Ehhhc+Gplppll.pl.p.......................	0	2	7	11
+15454	PF15594	Imm30		Immunity protein 30	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an all-beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-HHH or Ntox24 families [1].	23.20	23.20	25.00	25.00	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.47	0.71	-4.03	40	70	2012-10-05 20:22:57	2012-10-05 21:22:57	1	1	61	0	24	80	1	120.60	23	86.37	NEW	pplhssptlpplasp.hPshpcsclhslplc+pss.........pLslph.....hhpchsps..Pp+W..spass........hhlslsFhslppLpl.....suhuppshlsplplppssst.h..........plslps.sssh......phpC....cahplpsls.sa	.....hhssptlhslaGp.hPshccs-lhslplpRsss.........pLslph.....hspc.spsh.Pp+W..scass.........hhlplsFhslpsLpl.....puhuspsllsphclp.ph--p.h..........hlcIcs...psph......hlpC....cahclcsls.s.................................	0	4	11	16
+15455	PF15595	Imm31		Immunity protein 31	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved tryptophan and Dx[DE] motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-RES or Tox-URI1 families. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1].	29.80	29.80	35.20	34.10	25.50	25.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.41	0.72	-4.28	33	97	2012-10-05 20:23:36	2012-10-05 21:23:36	1	2	91	0	16	77	0	106.30	27	70.46	NEW	p.hhhlcpc..tshslsL.l.tctchp.hsp+hc-..Gh-u..sGYsWtulhpsalpcct..PcL..h-clcaDPEAGhFsA.Y....upst-sLcchsthlcchh-scphlhcll..pts-lp.	...................................h.lhphp...shslsh...pppcshthsphhpp..shcu..sGYsWcuhhphalpcht..Pcl..h-thphDPEAuhFsA.Y....upsh-slpclsphlpshh-s-chlhphl..pts...t...........	0	5	12	14
+15456	PF15596	Imm34		Immunity protein 34	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly alpha-helical fold and conserved aspartate and cysteine residues and an SE motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the LD-peptidase or Tox-Caspase families [1].	26.50	26.50	26.50	70.30	25.60	18.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.32	0.72	-3.89	3	76	2012-10-05 20:25:01	2012-10-05 21:25:01	1	1	76	0	2	35	0	91.60	92	74.39	NEW	MA-+uILsSLlusposEu+uACSto.aACsuA-hAELGLAhluuSc............................ScAuscuLVNLhRaRlDGALSE-YsCYLLo+G+ulsstLc+LsAKpLAucChpTFsclK+R.sht	......................hADKuILWALISASspEGRKACSLSYFuCKAAE.AELGLAYMAAND............................NKEFLTSLSNIMRYKIDAGLSESYTCYLLSKGKIIRPYLKNLNPLQLAADCIETVNKIKDKNKK...	0	1	2	2
+15457	PF15597	Imm36		Immunity protein 36	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved [DE]R motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox13 or Ntox40 families [1]. In some proteins this domain is fused to the Imm38 -like (PFAM:PF15599) immunity domain.	25.00	25.00	26.60	26.40	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.22	0.72	-3.86	31	66	2012-10-05 20:00:33	2012-10-05 21:26:13	1	3	33	0	6	64	0	92.00	35	93.27	NEW	.slcp.Kp-l.ppIcchGY-SL+YslFs..Epp..pt.Wts+l.Ycs..sca.V.upcDRu.lsG+.hEFssFp-AKc+FlchL-hhVptN+htlcpGhss.YsSPLWD	.................phtp.+t.l.ptIp.hsapsL+.YslFp..cpp..ph.ats+l.hpp..spa.VYsTsDRuShs.GK..hpFpsFp-AhcpFlphLp.hVh.N+htlcpG.sspYssPLWp..........	0	3	3	6
+15458	PF15598	Imm37		Immunity protein 37	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved arginine. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox40 family [1].	25.00	25.00	30.30	29.60	22.00	23.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.76	0.71	-4.37	27	97	2012-10-05 20:27:06	2012-10-05 21:27:06	1	2	64	0	16	59	0	153.10	32	84.76	NEW	..tchhphsttuGhshssssss................hhhssssptthhlhppsut....ah.h.....sps-Rupttt.....hh...hssshsslc+allhhhusplRts..hpLPtlthPhs.pslssuaslpphs.t.........ht.lhsspssslshshsst.....hphssLSahhshshp-Lhs.ualc....ssG....tPLh	.....................................scl.sahphuGhshhtsscs...............hhhhspGucsthalpchsGh....ah.l......spo-Rhsccs....hph...uuuShsllEKYLhshaGsslRuc..+cLPsl...psPaps--lhPpaolsshshs........hss.LlsssGosluhssssp.......LlpLSHhLslolsslcc.SaLDs-G...pPLh.............	0	8	13	16
+15459	PF15599	Imm38		Immunity protein 38	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved E+G and ExxY motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox40, Tox-CdiAC and Tox-ARC families [1]. The protein is also found in polyimmunity loci in polymorphic toxin systems.	25.80	25.80	25.80	26.80	25.40	25.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.43	0.71	-4.59	30	130	2012-10-05 20:27:51	2012-10-05 21:27:51	1	2	118	0	19	109	1	116.40	27	77.94	NEW	.tclpsclhclut+lusss..ths.hhstp....t....hs-uts.lhhssst....Y+hhhhERGphhpccpTssh-ElLYWlhcslspshAhchthpptss.........c.pshR+lhascph..cLlsslssc...WupcttpchsthL	.....s.chpphh.chttchsh.p...phs.hhhtp.....t......stGp..h.hsppt....YhhhhhERGpt.schpTssh-EhhY.lhpclshh.huhcathc+tht.........c.pctR+ltFpKpl..pLhstlNss...Wtccstpphsthh.....................................	0	2	8	12
+15460	PF15600	Imm39		Immunity protein 39	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved DxEA motif and arginine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-ColD family [1].	25.00	25.00	27.40	32.10	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.36	0.71	-4.43	8	16	2012-10-05 20:28:56	2012-10-05 21:28:56	1	1	16	0	4	13	0	175.80	43	95.36	NEW	MuSaIulG...........hVYc..s....csphpslIcha...l-LlusIssl.........Kh.s.hscsh-u-lhpshsl-chch.cssauplo.......cIpscllp.cslphhlRh.cEpcY.GlLhDIuE-cLltspSs-plE...pcLIsllhpIYpsssY-auFCDsEAEl-h..sPpslcPl.cssYullhhPc..Nsch+VhhssWcIDGlTpRpc+...	MuSalSsG...........CVYK.......puShKNllKhY...IDLluShANl.........-IENllChssEu-lppTcsLEElch.-ssFSplT.......cIsCK.lc.csl-hslRhhcEpsYpGVLFDlS.DaL.EhhSscpLE...NcLIsIlhsIYshhPY.FuFhDoEAEl-h..NPpslcPl.csPYAhLlhP+..Nsch+VYhssWcIDGlopRpc.......	0	2	4	4
+15461	PF15601	Imm42		Immunity protein 42	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved tyrosine and tryptophan residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-REase-10 family [1].	25.00	25.00	30.90	30.90	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.59	0.71	-4.74	33	74	2012-10-05 20:38:09	2012-10-05 21:38:09	1	1	69	0	17	69	1	125.60	35	92.37	NEW	VGhclshhha-lGpsshlauFFSTlshpLEpstWGo+aPhLhscL.YpGpLph-clppAhpELcpIcptLpphs.PspVl..WDh-sl.sppPPW.usplusslssLusYFhTscGcshh-lltcAl-pA.............hcpphclhIp	........VGhtlshhhaplGpsshlauFFSTlshplEsptWGo+aPlLMpcL.YpucLphcclppAlpELcpIpp.Lpphs.PspVl..WDh-cl.sppPPW.GssIssclssLusYFhTssGpshhcllhculppu.............hc.phsl.I.p.........	0	4	10	13
+15462	PF15602	Imm43		Immunity protein 43	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly alpha-helical fold and conserved arginine and phenylalanine residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox48 family [1]. This domain is often fused to the Imm72 immunity domain.	27.20	27.20	29.70	29.20	25.30	19.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.10	0.71	-4.30	15	39	2012-10-05 20:41:16	2012-10-05 21:41:16	1	2	20	0	15	42	0	171.40	31	51.90	NEW	hss-hpRRplFaLLK+hoSaThWpRhh-hapsFAsshEcsl+phsts...-.stl.sschssILcsLA+hEcGlpcLp+G......................s+pla+hstshE.....huhsc.....t...pss......uaW.cth.phtshts.pls.sh.th.......hphsPhtsth.ppsltpLtssht.lssshhEstFh-.shP.ha	..s--hsRR+lFaLLp+hTSaohWcRth-hattFAstaEpsV+shPps........-.ptl.ssplstIhchLAth-cGlpcLt+G......................sRhVaphGpsh-.....huhcc.s.hsshhasps......saWccth.phtsh.s.pls.shsth.......hphuPhtst..ppshtpltshth.l.sstY-ptFhshshP.sa......................................................................................................................	0	0	0	6
+15463	PF15603	Imm45		Immunity protein 45	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-ARC family. This domain is also found in heterogeneous polyimmunity loci [1].	25.00	25.00	29.20	28.20	23.80	22.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.59	0.72	-3.84	16	55	2012-10-05 20:41:55	2012-10-05 21:41:55	1	1	53	0	12	43	0	75.10	44	98.95	NEW	Mhlss.ssutlpl-lspGthhph.pGEhlhs.............spFllahsolppW-sPa-s..lotsEhppIlctlpcphscpshplsF-	........MKIoG.spStlpFDLENGallKA.pGEhLls.............GcFVVa+DSMcsWEPPaEscplopsElpcIIppVcppps-pTlplsF-....	0	6	8	9
+15464	PF15604	Toxin_43		Putative toxin 43	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a most all-alpha helical fold and a conserved HxxD motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion systems [1].
	25.00	25.00	27.70	27.00	24.50	22.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.16	0.71	-4.17	30	88	2012-10-05 20:43:07	2012-10-05 21:43:07	1	8	64	0	11	97	2	123.50	36	39.38	NEW	..sppcttEFcRQLcsQEcGLNcLTV-EalcNRptahsss...psp-sssspcARcc..hpcclc-phpppl....utp.....h..pAcppApcphpolAALHNPDhlAGGcsh......................IushGD+plNSSIGuQW+.......sRIssL-ptAccsspsh....ppssthNlKLp	.......................................t.p.tEFt+QLpsQppGhNch...TVcEalps.t.hhtts...........hthpsthtppstpc.....hppclpchhppth...ph.........tApptAtch......hps.AALHNPD.lAGGps.......................IsshGD+plNSSIGsQW+..............RlttlDtthpp.hscph....htsshhNl+L........................	0	3	6	8
+15465	PF15605	Toxin_52		Putative toxin 52	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all alpha-helical fold and conserved aspartate and glutamate residues, and K[DE] and[DN]HxxE motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5 or type 7 secretion system [1].
	25.00	25.00	27.70	27.40	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.21	0.72	-4.14	8	23	2012-10-05 20:49:50	2012-10-05 21:49:50	1	7	23	0	4	26	0	91.40	45	7.60	NEW	stLosuQpssls+l-Nh.......IpsHLTDtDhoGThRDLsGsPV.PKss..GGYWDHlpEMpDoh+GLpNhp+sLcs....LsNPshsppstthhQutLscAspplcKIEshhcs.	.......stLsppQcuulc+IDNs.......IcstLpDpDl.GTL+DhsGpPV.PKps..GGYWDHhQEMpNoh+GL+NptcTLcs....lsNPp........hQutascAoctlsKIEshl+.u.	0	1	3	4
+15466	PF15606	Toxin_55		Putative toxin 55	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved lysine and cysteine residues, and GNxxD and WxCxH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1].
	25.00	25.00	28.40	27.60	20.90	17.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.49	0.72	-4.01	5	65	2012-10-05 20:50:46	2012-10-05 21:50:46	1	10	64	0	3	72	0	75.50	87	9.54	NEW	GhAlu...shMAuPGNQADTGIsccVs-lhs-thhsuGK+PDRC-VLQpLID....sGsIuAKs.AKuTQKAWGCRHSRHS+D+	.....GLALD..ITMIASRGNVADTGITDRVNDIINDRFWSDGKKPDRCDVLQELID....CGDISAKD.AKSTQKAWNCRHSRQSNDK.......	0	3	3	3
+15467	PF15607	Toxin_60		Putative toxin 60	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha-helical fold with conserved DxK, GNxxxG, and DxxxD motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6 or type 7 secretion system [1].
	25.00	25.00	32.20	29.50	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.48	0.71	-4.04	62	137	2012-10-05 20:52:01	2012-10-05 21:52:01	1	12	114	0	26	125	1	105.80	30	31.36	NEW	shhhahppVpssusWDaK.pht.th............................h....tth.hhh-sauNhHYGalGpAh..GhspshLhpuAGhsQhhssstp......................................shhDDssDphsIphGlchapp.	..........................................................shahttVpssusWDaK.pht.th...........................hhhp..tphthhaDsauNlHYGYVGhuh..Ghs-shLLtuAuhtQhhsstt.......................................shhDs.sDptsIphGhphapp.p....	0	10	18	24
+15468	PF15608	PELOTA_1		PELOTA RNA binding domain	Anantharaman V	la_psag	Anantharaman V	Domain	This RNA binding Pelota domain [1] is at the C terminus of a PRTase family [2]. These PRTase+Pelota genes are found in the biosynthetic  operon associated with the Ter stress response operon and are  predicted to be involved  in the biosynthesis of a ribo-nucleoside  involved in stress response [2]. 	25.00	25.00	25.10	47.60	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.34	0.72	-4.24	65	343	2012-10-10 14:40:03	2012-10-06 20:01:06	1	7	333	0	72	266	2	102.60	39	24.86	NEW	psps.sp..ht.hhs..spps..phpuh.pslcpltpcasIsslNhlKPGlGEsTRVLLRRVP.+lLl+.stss....s-lsHlhhLAcc+GVs..Vcphs..sh..sYsslulI+slt	............................tsh......hth.hpsspshphpuhpslppl.uccapIsslNhIKPGluEsTRslLRRVP.+lLVR.sh..ss....PDlshllhLAc-KGlsVcEhs.sh..tYpslslIKplh...........	0	20	44	60
+15469	PF15609	PRTase_2		Phosphoribosyl transferase	Anantharaman V	la_psag	Anantharaman V	Family	This PRTase family, with C terminal TRSP domain, are related to  OPRTases [1], and are predicted to use Orotate as substrate. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	35.20	35.20	39.00	40.70	31.40	30.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.26	0.71	-5.00	67	330	2012-10-10 14:25:38	2012-10-06 21:18:51	1	4	322	0	70	261	4	196.20	43	44.89	NEW	slscL.....hshAtR.+NPKRuFLFVS+VLGKHlPlsPsshhsshppLApthstpl...........................................................................sts................slhIGhAETATuLGpuVacsh..p.s..tp.........YLHoTR+s.lss.....p..hspFcEpHSHAosHlla.sss.shhps....su...s.LVLVDDEhoTGpThlNllpuLppt..hP...h.cchllsoLlDW............ps.t..ssltpcls.l.....lssVSLlpGph	..............................s.lcsLhslAtR.R.NPKRAFLFVS+VLG+HlPlpPushhpshppLApphss.sL...............................................................sss.............lLhIGhAETAsGLGtuVacplptpp......hYLpSTR+slsu.....shhspFcE-HSHATsHLlYhsss....th.hpp.....uc.slVLlDDEhTTGsThlNllpAL+sp..hs...hcphlssoLsDW........pt.......sslscch.s.l..lssVSLlpGp.........................	0	20	44	60
+15470	PF15610	PRTase_3		PRTase ComF-like	Anantharaman V	la_psag	Anantharaman V	Family	This PRTase family is related to the ComF PRTases [1]. These genes are found in the smaller biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	110.50	110.50	192.20	191.90	29.10	28.50	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.79	0.70	-5.48	17	23	2012-10-10 14:25:38	2012-10-06 21:57:01	1	1	23	0	9	24	0	273.30	30	91.63	NEW	Mhs.thSLHpItsss..phsFssssYSRaKaGDsphAcpFGppLhcuFIsp...........htstphps-plVhlsSsapplPTAopsLppaFlppLNpaLhppstpsslpsKlhRsto.hp..DYusLshE-R.pl.ts-saaIDpphl...pG+sllFlDDI+lTG.S+Ectlhp.hpphtlcs...chhaLhhs-..ppsh..csslEspLN.hsVcohpD..ltplhpussFphNpRhVKalLsts.s-.ashFlp..p.scshhppLhchAluNsYH.p.ppYpsNlphLt..l.....shtuh.................	......h...thuLapIhsss..phsFssssYSRaKaGDsphActaucpLhcsFlsp...........apsthhps-plVhlsSsapslPTAossLppaFVccLNpaLscput.sslpsKlhRhto.sp..DYusLshE-R.pl.tsssaaIDp-hl...sG+plIFlDDl+lTG.S+EcpVhp.htphslcu...chhalhhs-..spsh..csslEs+LN.hsVcshhD..ltpllsussFphspRhlKalLutsppc.hssFlp..phssshhppLachAluNpYa.p.ppYtsNLshLp..l......h.......	0	3	5	7
+15471	PF15611	EH_Signature		EH_Signature domain	Anantharaman V	la_psag	Anantharaman V	Domain	This domain with a strongly conserved glutamate at the N-terminus  and a histidine at the C-terminus [1], is found in a SWI2/SNF2 four gene operon [1]. Its strict-neighborhood association with\	\	    SWI2/SNF2 ATPase strongly suggests a function in conjunction with it [1]. The other genes in the operon are a OmpA protein and a TM protein [1]. This has a DNA related function along with the TerY-P triad [1].	25.00	25.00	41.50	40.40	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.60	0.70	-5.41	79	135	2012-10-09 15:52:58	2012-10-06 22:16:26	1	1	129	0	40	115	7	383.70	22	79.64	NEW	h.phshcplhstlppht...hstplps..........phhhhshs..h.h.....p...th.t..sp.........t.hhshlhp.........ht...ph..pptshtsLhpsYhstas............pthtshh..........lttph...thppt..........hhphhpphp....tlhsspss.th.lspphhp..st.ts.hptl..t....phslss....ssahtpshhthhlpphtphp....spthl.............ccl.ph.h...lh....ps......hhphtsphhpthLphah.p..pt..t..pphcpt.lpphl....ls...hhG-Ppltss..p......Wtt........lsc........pstphlptWLscp...slchFFpllp..t.st................h.ptRtpFWhpahcp..lspshlhhuss..Ahp.hppthtt...tth.s.phu.php........p.s..spsshlhpl...s....sh.hhVE............asssupshhhap.ps...ph...........s..pthp....h.....thstpl.....+pts..........sh.t................ph....sH.ps...............sWpt+hpphL	................................................................................................................................ht....shtplhstltphp...htp.lss..........plhhhslsh.h.tt.tp..tph....sc....plhstlhc.........hhpp.pphshpuhhptahspas..s...t.cshtsah..........lttph..pspcp.............ph.p....pllsssus.phlucphhp..sp..hsh.chl..t....phtlpp...tupahstshhhhhlcplspls.....-cshl..............-cl.ch.h..lh..cu.........phctpshlhptlLphhh..t..ps...s..sphpcshhphl....Ls...hhGDP+lsssssp....Wpp.........lp.............shhphlhsWLsch...DLchFhchlpths.t.............thh.sRcpFhpthhct..lsps+lhLu.c..Atphhpppht....cph.spauplp......csspuhlhhph.s....sh.hhVE...........a.csu.ssh.asYp.hs.p..............s.pphp..h.....shssph...........pchs.p.....sht...............+lsHss...........uWppKhht.................	0	10	19	29
+15472	PF15612	WHIM1		WSTF, HB1, Itc1p, MBD9 motif 1	Iyer LM, Aravind L	la_psag	Manual	Family	A conserved alpha helical motif that along with the WHIM2 and  WHIM3 motifs, and the DDT domain comprise an alpha helical module  found in diverse eukaryotic chromatin proteins [1].Based on the  Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins [1][2].  The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes [2]. The conserved basic  residue in WHIM1 is involved in packing with the DDT motif. The  module shows a great domain architectural diversity and is often  combined with other modified histone peptide recognizing and  DNA binding domains, some of which discriminate methylated DNA [1].   	16.70	16.70	16.70	16.70	16.60	16.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.02	0.73	-8.48	0.73	-3.75	36	528	2012-10-09 18:07:10	2012-10-07 01:56:28	1	70	195	2	305	505	1	49.50	21	3.66	NEW	pptshspthpptsa.............hplsspp+lplLphLschh...hsssshpshlppptctt	.....................................h....hh.thpppsa.............hplssppKlplLphLscph...lsottl+shlppp....h........................	7	53	121	197
+15473	PF15613	WHIM2		WSTF, HB1, Itc1p, MBD9 motif 2	Iyer LM, Aravind L	la_psag	Manual	Family	A conserved alpha helical motif that along with the WHIM1 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [1]. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins [1][2]. The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes [2]. The acidic residue from the GxD signature of WHIM2 is a major determinant of the  interaction between the ISWI and WHIM motifs. The N-terminal portion of the WHIM2 motif also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.77	0.73	-7.97	0.73	-3.82	15	298	2012-10-09 15:57:33	2012-10-07 05:24:23	1	45	177	0	195	286	0	41.60	35	3.52	NEW	RppsLGhDRpts+Yahh........................tsspslhltcp.s	...RtpPLGpDR.tNRYWaF.....................................s.....t..tpsthahp.........................................................	0	38	95	146
+15474	PF15614	WHIM3		WSTF, HB1, Itc1p, MBD9 motif 3	Iyer LM, Aravind L	la_psag	Manual	Family	A conserved alpha helical motif that along with the WHIM1 and WHIM2 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [1]. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins [1][2]. The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes [2]. WHIM3 along with  WHIM2-N constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA. The module shows a great domain  architectural diversity and is often combined with other modified  histone peptide recognizing and DNA binding domains, some of which  discriminate methylated DNA [1].	18.10	18.10	18.10	18.10	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.32	0.72	-4.18	35	259	2012-10-09 17:50:33	2012-10-07 06:11:50	1	43	130	0	154	252	0	77.50	32	6.14	NEW	WthhpstcplcpLh..csL.................................................................................................................................................................................sscGhR...EppLpppLtphh....pplpssh	.....................................................................................................................................................................Wthhscscpl-pLl...puL..............................................................................................................................................................................................pPpGhREtpL+ccLpp............................................................	2	27	51	96
+15475	PF15615	TerB-C		TerB-C domain	Anantharaman V	la_psag	Anantharaman V	Domain	TerB-C occurs C terminal of TerB in TerB-N containing proteins. This domain displays multiple conserved acidic residues (TerBC) [1]. The  presence of conserved acidic residues in both TerB-N and TerB-C  suggests that they, like the TerB domain, might also chelate metals. These two domains might also occur together in the same protein independently of TerB [1].	26.30	26.30	27.20	27.40	25.40	24.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-11.01	0.71	-3.94	140	224	2012-10-09 17:52:00	2012-10-07 20:41:01	1	11	214	0	64	226	6	149.20	21	22.62	NEW	slcshts........................tpptst.ss...................lplDhsclsplcp-sspspthlss...........lhs--c............tp.........................................-.t...p......................ht.p..p...ts..............pssss.......................................................G..L-s.......sctphLchL..........lsc.pp..W.ctchpphstph.............pLhhsssl-pIN-hsa-ths-sllE...s..s-shtlst...-hhccLp	..................................................................................................................................................s........................p.......hplDhsplstlcp-sppsp....ss...........lhs--p.....t...............................................p..p..................t.t.ps....s........t.tss..........................................................h.u.Lsp.......schphLchL.....lsc.ps.a.htphpphspsh.............plh.lsshl-pIN-tha-hhsssll-...s..s-shtlsp-htpcL........	0	21	41	52
+15476	PF15616	TerY-C		TerY-C metal binding domain	Anantharaman V	la_psag	Anantharaman V	Domain	TerY-C is found C terminal to TerY-like vWA domains in some proteins [1]. It has 8 conserved metal chelating cysteines or  histidines [1]. It occasionaly occurs as solos [1].	28.40	28.40	29.30	75.20	27.60	27.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.31	0.71	-4.22	48	97	2012-10-09 18:02:15	2012-10-07 22:23:15	1	2	92	0	17	68	6	127.90	48	40.28	NEW	ssshD-shVllsG+C....s+T++PYLhKYER......t..sh.t....h.plphpta..p...lsGsaPlD.csYhsa.SDspssstplNTo-LhGs..PGCPaCGNthuaAhC..s.CG+lhC.l.sG.sc......pssCPWCsp.sssau.sss....ss.FDlsRGcG	..spAaDENCVTLsGRC....SKTRRPYLhKYERP....sspl.ouLs....F.pLNlsuF..NluGCYPID.EDYFuWS.Dtosou.QVNTS-LhGs..PGCPaCGNtsAFAhC.s.CGKLhClsG.sc......cVhCPWCtpshsausss...tssFDlsRGRG.....	0	5	11	14
+15477	PF15617	C-C_Bond_Lyase		C-C_Bond_Lyase of the TIM-Barrel fold	Anantharaman V	la_psag	Anantharaman V	Family	This family of TIM-Barrel fold C-C bond lyase is related to Citrate -lyase. These genes are found in the biosynthetic operon, with other  enzymatic domains, associated with the Ter  stress response operon  and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	217.60	217.60	221.30	220.40	214.70	214.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.11	0.70	-5.63	70	344	2012-10-10 15:06:27	2012-10-07 23:05:45	1	2	337	0	72	251	6	324.30	42	93.39	NEW	phhsauLGATLYhPATRpclAcslhcp+hsGlpSlVlCLEDAlu-p-VshA.pNLhphLppLsst............................ptsshPLlFlRsRssc.hppLssth......slphlsGFVlPKF...............stpshpsah-hltp..ss...............LhhMPsLEo.-lh....csppLtpltphLspa..+-plLAlRIGusDLhulhGlRRs+chTIYD.ssluslIsslVslFutt....uaslouPVaEaa.ss.p..............................................sLhRElsLDhANGLlGKTsIHPSplssVpuhhhVopE-apDAhcILs.s.s.p......uVhKSs..spMsEstsHppWApclLtRAclaGV.hscstshsphh	.......c..sasLGATLYhPATRpcIA-sllcp.Kh.....s.GlpSlVlCLEDAlu-s-lshA.pNLhphLppLusthtt.........................stsshPLlFlRsRpsp.hptLhsch..............slptlsGFVLPKF...............T.sshssah-hhsssp...............LhhMPsLEot-lh....cstphtpluptLcpa..+-RIlALRIGusDLhulhulRRs+chTlYD.sshu.lIt.lVsVFu.t....sFslTuPVaEahsspp...........................................sLh+ElsLDhApGLlGKTsIHPuQIpllpshhhVopc-asDAhcILss..sp......uVhKSp..stMsEstsH+pWAppILpRAchYGlhs-pss.....h........	0	23	45	62
+15479	PF15619	Lebercilin		Ciliary protein causing Leber congenital amaurosis disease	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95447	Family	Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localised at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia.  Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.	26.00	26.00	26.00	26.00	25.50	25.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.94	0.71	-11.35	0.71	-4.88	31	158	2012-10-08 11:36:17	2012-10-08 12:36:17	1	4	81	0	93	142	1	180.10	39	32.43	NEW	hls+RlLSARLhKIp.ELcN-ls-lph+L--ltpEN+hLKpLQhRQcKALs+aEsopsElPQLlspHpsEl+sLRccLRKoQE+ERshc++L+-s-scLh+s+ssLp+Lp+Lu-D+pLsER-ELsc+Lsthps+hpps-++IppLEKpLcLsspuFpRQLtsEp+KstpApppsctLppElppLppKLKEKEREL	..............h.hs+RlLSARLhKIp.cLpN-ls-lph+LpplhpENchLKpLQhR.ppKAL..sKaEsspsclsQLl.t+HpsEl+sL+ppLRKSQEcERssp++l+-s-s-Lh...+.......s+ssLp.......c....LpcL.u-s+pLsE.R..--L...sc+Lsthpt+h-ss-++Ipp.........Lp+...pLcLsspsapRQLhsEp+KshpspppschLphElppLppKLKEK-+pL...............................	0	25	30	57
+15480	PF15620	CENP-C_mid		Centromere assembly component CENP-C middle DNMT3B-binding region	Coggill P	pcc	Pfam-B_64009 (release 26.0)	Family	CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability.  This middle region of CENP-C is the binding-domain for DNMT3B. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats.  CENP-C and DNMT3B regulate the histone code in these regions [1,2].	27.00	27.00	183.80	183.80	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.95	0.70	-4.67	13	40	2012-10-08 12:56:00	2012-10-08 13:56:00	1	5	23	0	16	32	0	248.70	59	31.10	NEW	hKL.LEDEFIIDESDpSFASQSWITIPRK.ussLKQpoVsPsESTAlLQuKKSREKHH........slSPpTLTSDKHScKA+PVEKSQPScp++LupSCsLosEhENssRSTKpEhaSENAcKsSGsKRTlcQK.Q++KhKsNlsEEplchtQSK-cNlNh..SHIsQDKLQRNSDRNMc-sEEhpNsslSKKQhPsV.GsKKpoo......ppKK-K.cuKKK+FSstSpKNKlVP-EVT.TlTRSRRISRRPSsWWVVKSEpSsl.SN.oSlRNELsV	....hKLlEDEFIIDESDpSFASpSWITIPRK.uGsLKQ+slS.PAESTAlLQu+KSREKHH........sl.PpTLsssKHScKsHPVEpSQPS-cphLssShALosEhENshRSTKaEMaScNAcKsSusKRTIKQK.QRRKaKApsuEEQLDhGQSKDENIph..SHIsQDKhQRNSDRNMEEpEEhtN-sl.SKKQMPPV.GSKKsSs........+KDKtEuKKK+FSsES.KNKLVPEEVTSTVTRSRRISRRPS-WWVVKSEESsV.SN.SS.lRNELsl...	0	1	1	1
+15481	PF15621	PROL5-SMR		Proline-rich submaxillary gland androgen-regulated family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:P02814	Family	SMR is a family of proteins found in eukaryotes. The family of SMR proteins is expressed in the submaxillary gland. SMR members may play a role in protection or detoxification.	24.90	24.90	25.00	24.90	23.10	21.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.82	0.71	-3.64	16	60	2012-10-08 13:28:38	2012-10-08 14:28:38	1	1	16	0	13	58	0	99.30	40	68.32	NEW	MKsLsLlhGLWsLhuCFpsuEspRGPRt.asPt.......ssPPs..PatsthhPsPsPPsaGsGhssP.P.......husGhh.Pss..............s.htsh.......l.ssss.P..sPuhP	.MKsLshlLGLhALhuCFpsuESpRGPRtPYsPG........sPP...PatPtaVPPPsPPPaGsuphsP.s.......assshh.Pss....s.s..........s..................................................................................................................	0	3	3	3
+15482	PF15622	CENP_C_N		Kinetochore assembly subunit CENP-C N-terminal	Coggill P	pcc	Pfam-B_21609 (release 26.0)	Family	CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].	27.00	27.00	126.40	104.90	17.80	17.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.74	0.70	-5.16	10	50	2012-10-08 13:43:13	2012-10-08 14:43:13	1	6	23	0	19	35	0	223.80	58	35.09	NEW	DHLKNsYRRRFCRPS.RAPsINTEQGQNlLEILQDCFEEKShANDFSsNSTKSVlhSTPKlKDhClQSPSKE..CQKSHP....KSlPVSSRKKEusLQhhlEPSEAusRSVQAaEVHQKILATDVuSKNTPD.+KhSS+KhcD+HuEuDEEFYLSVGSPSVLLDAKsSsSQNAlPSsAQKRETaoScNSlNhLSSSTEIShKT+KRLNFEDKslLKKlEIEscVSclEDKlSEt.QE+KsScTSQKRlQDoEhEIQPQAKKSFSTLFLETVKRKSESSsVVRHsATsPPHsSP	...........DHLKNtYRRRFCRPS.RA.sINTcQGQNlLEILQDCFEEpShAssFSsNuTcSl..ST..KhKD.plQSsSKE..sQcSHs....KSlPVSS++KEusLQh.....sEP....sEssscSVQAHEV+Q+hlusD.VtS+sTss.p+hSS..+ph.pshcs-AsEEFYLSVGSPsVLLD.AKsS..s.QpslsSsAQKRETYT.cNSVNhhsSST-lShKT+KRLNFEDKshL+phEItNpVSc.EDKhSEt.QE++sStoSQpRhpDoE.EIQ.puKKSFSoLFLETVKRKScSSslVRHhAssPsp.sP.............	0	1	1	1
+15483	PF15623	CT47		Cancer/testis gene family 47	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:P0C2W7	Family	CT47 is a family of proteins found in eukaryotes. Proteins in this family are typically between 262 and 291 amino acids in length. There is a conserved HIL sequence motif. The function of this family is not known.	27.00	27.00	149.70	149.60	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.89	0.70	-4.66	14	37	2012-10-08 14:01:00	2012-10-08 15:01:00	1	1	15	0	12	35	0	262.80	50	96.59	NEW	MSsTGDtDPspssQEuPso.tGuQuttutAt-uhutDSuPssG-.....ssPtscsuGlsGP.tG.pEt....EG............GsAEEDSDItss.........E-tptpppstuhshhVsA++FPMsGFRhhFLDLVHShLpRlYaNDHILIcspp.shlhht.ptst.............up.tpstlhhhsphhssussshEGpu.sLh....p.ht.hP..EPs..u-.sE.ApE.........tcssEEusthEsApctscE.....................u.E.tspEsstPE..........chsctQsEc.cEEAQsstu-tcccp.pccppc	..MSATGDtcPsQsDQEAPVSQEGAQAEAutAGstEGuDSGPcSuD.....hVPsAEssGVAGPhcGLuEE.....EGEQt.....tuLAAsPhsGuAEEDSDItss....E....EEEEEtppAsNhDlsssuRRYPhsGhRhhFLDhVHSLL+RlYHNDHILItsRp.uRLMhts+sus............Ps.h.spsslLLlspRLGsGAsuhEGcuLGLl......pEAAoVP..EPsVPA-.AEhApEPt..............EEuAEEt.sEEsAE-.spEc...........u...........uEEPs.....spEAsAPE..........ElTK.Q.EKW-EEAQsusuEEcK-ptpcKstc........	0	2	2	3
+15484	PF15624	Mif2_N		Kinetochore CENP-C fungal homologue, Mif2, N-terminal	Coggill P	pcc	PB002175 (release 26.0)	Family	Mif2_N is a family of fungal proteins homologous to mammalian CENP-C. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].	23.50	23.50	24.00	24.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.99	0.71	-3.57	44	123	2012-10-08 14:07:44	2012-10-08 15:07:44	1	7	115	0	94	122	0	132.60	24	21.73	NEW	cahslGhpuR..........KTGlslc-pGpRDEaGMEslDshFSSP-c..oslp.........................ttt.ppuSp..sMchsss.ssssPsshlss.........tpp.th.sPpu.poP...........t...h....p.tht...toSshppsstpss...................ts.hppch-..h	................................phhplGhtuR..........KTGlsl+cpsp+DEaGMEsl-shFuus-c.ushp........................................p...tp..ssptsSp....shshsss.stssPsshlps.........tpp.hh.s..Pps..pos.............ht...s.ht..us....spR.........s..ht.........pSsh.p....tt..............................................................................................................	0	20	50	80
+15485	PF15625	CC2D2AN-C2		CC2D2A N-terminal C2 domain	Zhang D, Aravind L;	la_psag	Mannual collection	Family	Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition\	zone of cilia [1]. This is the first C2 domain of ciliary CC2D2A  proteins which also have another C2 domain (CC2D2AC-C2) and  a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).	25.00	25.00	26.80	25.90	24.60	24.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.47	0.71	-4.78	20	138	2012-10-10 12:23:49	2012-10-08 22:33:14	1	4	88	0	84	110	0	160.10	33	11.78	NEW	tPG-sphhspLsssssls......ssspsPpsEtsRRpphpphphalplhlNs.......ppVspopsp.L...tssFssphscthplpl.p+.hPcslplplaEsss...htsphlupVhlPlPsstssh.hs...............tspphpFoocp.hp.sh.h.s....................ppssphhsGslhhsssWsptpstt.s	.............................PtEshlhs.Lshssslo......ssptssp.sEh....RR.pclp+pphalKlhaNs.......KcV.u.pTps+sL..ssDF+lpFsplFsl........pl.hp.hPESlsLplaEsss...sssslLApV.alPlPpsosspups.............................shcphEFSSsptlthsapusGu.............hpsssssphhh...hTSGplshssuWuhscss..l......................................................	0	31	39	59
+15486	PF15626	mono-CXXC		single CXXC unit	Iyer LM, Aravind L	la_psag	Manual	Family	This is a solo version of the zf-CXXC domain with a conserved  CXXCXXCX(n)C, zinc-binding motif. This is, thus far,  only detected  in the plant lineage in diverse chromatin proteins [1].  Structural  comparisons show that the mono-CXXC is homologous to the structural- zinc binding domain of medium chain dehydrogenases [1]. The regular  zf-CXXC domain binds nonmethyl-CpG dinucleotides.	20.00	10.00	23.30	13.20	18.10	9.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.49	0.72	-4.02	7	7	2012-10-09 00:30:47	2012-10-09 01:30:47	1	4	4	0	7	8	0	44.10	22	4.97	NEW	cssuC.hCpsCtt.s.ssps.s.ttt.tsp...............tsspsspClplcsh	cssuC.hCpsCtt.s.ssps.s.ttt.tsp...............tsspsspClplcs..	0	4	6	7
+15487	PF15627	CEP76-C2		CEP76 C2 domain	Zhang D, Aravind L;	la_psag	Mannual collection.	Family	Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia [1]. This is the new C2 domain that is contained by ciliary  CEP76  proteins [1].	47.00	47.00	47.60	81.10	40.00	46.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.73	0.71	-4.72	16	82	2012-10-10 12:23:49	2012-10-09 01:37:56	1	2	63	0	49	79	0	157.60	51	25.06	NEW	hsphssscphLalclhsG+AFl-als.......................ssssophplplpatsQRFsSpsVssssEPsFsEpFLhcLcppshtts...............htsllslspPl+llllpsc.stpp..............pLlusphl-WRplLppss.............shslELtGhsspt.phssGlLplplELlPshpshh	...........p..plDPsRRYLYLpVLGGKAFLEHLp-s-s.................LsGQssSTFTLsLHFRs.QRFRS+PVP.CACEPDFcDGFLLEl++-uhGcusch..........................ssuTTMLSIuDPlHhVLIKTDhhGET..............TLVuSaFLEWRoVLuSpsGhs..........sLoVELhGVG...sEu.KVsVGILsl+LEhaPsLspsL...	0	18	23	34
+15488	PF15628	RRM_DME		RRM in Demeter	Iyer LM, Aravind L	la_psag	Manual	Family	This is a predicted RRM-fold domain present at the C-terminus of  Demeter-like glycoslyases [1]. These proteins  are involved in  DNA demethylation in plants where they catalyze removal of the 5mC  base and subsequently cleave the backbone through lyase activity.  Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic  domain with ssDNA or regulatory RNA [1].	34.60	34.60	34.60	35.00	18.20	34.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.40	0.72	-4.34	21	84	2012-10-09 00:46:22	2012-10-09 01:46:22	1	10	25	0	52	90	0	95.50	62	7.39	NEW	GTlLIPCRTAMRGSFPLNGTYFQVNEVFADHpSShNPIsVPRshIWsLsRRhVYFGTSVsSIF+GLosEcIQtCFW+GaVCVRGFDRcoRu............P+P...LhARLHhsso	............GTlLIPCRTAMRGSFPLNGTYFQVNEVFADHsSShNPIsVPRphlWsL.RR..hVYFGTSlsoIFKGLosc-IQpCFW+GaVCVRGFDppoRu............P+PLhs+LHhsss................................	0	10	30	41
+15489	PF15629	Perm-CXXC		Permuted single zf-CXXC unit 	Iyer LM, Aravind L	la_psag	Manual	Family	This is a permuted version of a single unit of the zf-CXXC domain  that is detected in the Demeter-like proteins of land plants.  Structural comparisons show that the mono-CXXC is homologous to  the structural-zinc binding domain of medium chain dehydrogenases  [1]. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.79	0.72	-3.95	10	47	2012-10-09 00:22:00	2012-10-09 02:18:17	1	4	17	0	28	56	0	31.40	54	2.09	NEW	PcppCsS.pEoG+LCs-pTCFSCNSlREspSQT	...PcppCsS.pEsG+LCsppTCFSCNSlREspoQh...	0	4	17	23
+15490	PF15630	CENP-S		Kinetochore component CENP-S	Coggill P	pcc	manual	Family	CENP-S is a family of vertebral and fungal kinetochore component proteins. CENP-S complexes with CENP-X to form a stable CENP-T-W-S-X heterotetramer.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.57	0.72	-3.80	46	231	2012-10-10 12:36:46	2012-10-09 13:40:56	1	9	190	12	158	473	3	72.70	38	43.37	NEW	p+LKuAlaasVGc.ls-E..p.sh....cpshs...so.phl......uALoEllapQ....lp.sl.upDLEsFA+HAtRoT.Iss-DVhLluR+Ns...sL	...........................pcLKuAlahsluplsc-.....s............ctshp........ho.phI......uAlsElsapQ.....................hc.sh.upDLEhFA..............+........HA.tRsT.lss-DVhLlARRsssL...........	0	47	84	126
+15491	PF15631	Imm-NTF2-2		NTF2 fold immunity protein	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein of the NTF2 fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-NucA family [1]. This domain is also fused to ankyrin repeats and the PFAM:PF14025.	26.00	26.00	26.00	32.10	25.90	23.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.32	0.72	-3.99	17	170	2012-10-09 13:50:12	2012-10-09 14:50:12	1	1	121	0	11	48	1	67.30	70	58.81	NEW	sAlclAEhhlh.lYGppl..ppKPahlshpssp..WllpGoh........ssp........hhGGshhIhIpKpDG+lLplhHsK	...AlpLAEIYV+.RYGpch.AEEEKPY.ITELssS..WVVEGsh.......hs.p.........lAGGVFIIEIsKpsGplLNFhHuK...	0	10	10	11
+15492	PF15632	ATPgrasp_Ter		ATP-grasp in the biosynthetic pathway with Ter operon	Anantharaman V	rdf	Anantharaman V	Family	This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo-nucleoside involved in stress response [1]. In press. Mol. BioSyst. 2012, DOI:10.1039/C2MB25239B. "Ter-dependent stress response systems: novel pathways related to  metal sensing, production of a nucleoside-like metabolite, and  DNA-processing" Anantharaman V, Iyer LM, Aravind L;	182.70	182.70	192.60	190.40	175.00	167.50	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.94	0.70	-5.69	99	206	2012-10-10 13:17:03	2012-10-09 14:55:16	1	1	201	0	43	148	9	327.20	42	96.59	NEW	hlWFhcGhSupppllpul+s..s.................................tslplhASHpppcstlhthADhuhh..EPp....sspc...............hlpalLchscppslclllsu+psph..httpRspFput.....GscLhs.ssshpslphh--Kspahtthcp.....t.Gl...sssssht.lsos-EL.psuh.ss....lth...s......sp.lClKPssGlhG.hGFhhlcp........sssshc.shtp...ssspp.lshpthlsuhpts....-ph.....shllMPYLsGsEhSVDhls.cp................Gc...llAAV.sR.+Ks.....G..hh.Qplppcsph.hplApchActhshcGlhNlQhRpc.ssGp.Ph.LLEINsR.SGGlshot.ts....GVNLPtlhs.thtLGhht..-....h............h....psh.pVpslosslth.s	...........pIWFhcGhSSpR-lIpul+shs.............................pshulplaASH+sp+spILphADhuhh..EPp.....Dspc.................hlpalhchspsasIchIhsGRssph..hEpHRuth-st.....GspLsTGusssshlslsD-Kspasphhcp.....pGL.PVlPohp.VsohsEL+stlus.....sas......sp.lClKPVoGIYG.hGFW+hDc........osushssFs+...s-pRhVosppYlsAhptu....EshpPhlLMPYLPGPEaSVDhLs-+................GcllAAVuRRKp......G..slQhLh.p-usAhELApcsAchhpsDGLVNVQTRsD.ssGp.PlLLEhNhRPSGGlsYTh.co....GVNLPGLFA.thpLGLhsp-h..sh......h.pslsVRulTssl.h.p....................	0	13	28	36
+15493	PF15633	Tox-ART-HYD1		HYD1 signature containing ADP-ribosyltransferase	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and aspartate residues that comprise the active site. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, or type 7 secretion system [1].	25.00	25.00	45.30	43.40	23.00	22.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.31	0.72	-3.18	18	25	2012-10-09 14:47:52	2012-10-09 15:47:52	1	12	21	0	9	25	0	97.30	27	14.38	NEW	lYHYTsccGhsuIh-Sshlp.....hpu.s.hp.thssGpYhoshuPGp......hp.ucuht+hsh.sss+ss+.al..ElDsss..Lphlcs..pcsshh.h.psslDlssct	.....laHYTsccGhpuIhcosplp.....hpupsshp.utssGtYloshuPsc.....................hphucuhtphsl.sssKsoH.aI..ElDsss..Lphlcs........pcsshhhh..ptslDlssp...............	0	4	8	9
+15494	PF15634	Tox-ART-HYE1		HYE1 signature containing ADP-ribosyltransferase	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and glutamate residues that comprise the active site [1].	25.00	25.00	530.80	530.50	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.96	0.70	-5.44	2	8	2012-10-09 14:52:20	2012-10-09 15:52:20	1	1	8	0	1	2	0	284.60	86	32.52	NEW	GLsL.pMlRNss.TLps....tPpKsEDGYYYHlopupNL.ShlppGFhPQGS.GPTLSttDhppRKhGlI+hIYohlATplN+schuK.KISpsNFhMPp-FWpEFK..hpsIsspssI-..sphLpcSIscuIst.LDpscFhcKHs-+Kpp.IsppR.tlhppDE.INcIIop+shh.QQREAtNTcGYIYLAsp+NTL.cYhhphpppps.hllLAl.-sIFotKhLEpD.QEPcsAVRYpGul.ot-LpFVNpEGQlssh.hShu....G-hILs..pVIsFh+K	GLNLFRMVRNNPITLRDDDGLEPKKAEDGYYYHLTNARNLMSIVEKGFIPQGSQGPTLSAGDLENRKKGVIRYIYTKVATELNRGEISKNKISSNNFKMPSDFWSEFKLEGSSITNDNDIESVNKKLNDSIVRGISAVLDKGEFKKKHNEKKSEDITRSRMRVMDDDE.INKIITQKPLLEQQREAANTKGYIYLAATRNTLEKYAINYKSSNDDMILLAIPDSIFSAKILEEDEQEPDCAVRYSGGVLSADLRFVNREGQVVPFEYSAS....GEIILDYPSVINFIRK	0	0	1	1
+15495	PF15635	Tox-GHH2		GHH signature containing HNH/Endo VII superfamily nuclease toxin  2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic s[AGP]HH signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type secretion system [1].	25.00	25.00	49.60	48.70	22.40	19.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.50	0.72	-3.68	21	50	2012-10-09 14:59:33	2012-10-09 15:59:33	1	7	48	0	12	40	2	100.90	30	23.52	NEW	pTGHHLIsspphpstst...............ptYspspAPslCs-Gssps.sGoHGphHsthpshththt............t.t.spastusspsssuhs..csastspCsccClctQLssaac	...QTuHHLIsspth+stup...............ssYocscAPslCsEGssps..sGoHGthHsthsshhtcpp...........hstp.tsassAcspshsuhu..pshstspCs+cCLcuQL-saap..........	0	1	8	11
+15496	PF15636	Tox-GHH		GHH signature containing HNH/Endo VII superfamily nuclease toxin	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive  of this domain at their C-terminus [1].	25.00	25.00	27.50	26.40	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.36	0.72	-4.34	38	392	2012-10-09 15:03:10	2012-10-09 16:03:10	1	43	112	0	171	362	1	78.50	52	3.34	NEW	-cE+pRllccA+pcAlcpAWpcE+ptlcsGtt.GstsWocsE+ppLLssGpVs............GY-Ghahhsl......ppYPcLA-sstNIpFh+	.......-EEKsRlL-hARQRAlspAWs+EQQ+l+-GcE.GsRtWTEGEKpQLLosG+Vp............GY-GaaVlSV......EQYP...ELADSusNIpFhR............	0	29	40	94
+15497	PF15637	Tox-HNH-HHH		HNH/Endo VII superfamily nuclease toxin with a HHH motif	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteristic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system [1].	27.10	27.10	29.80	29.00	25.30	23.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.37	0.71	-4.31	9	31	2012-10-09 15:05:23	2012-10-09 16:05:23	1	6	29	0	6	30	1	111.30	43	22.97	NEW	phsshssthlsDP+hsV-MsahG+GpssTNut.GWhRssKhFWpchhctpP-hhSpsNptpI.cpGh....uPhlDssalKaFPpa..sshhsDsLhHHHlGtGupAsslPssLHsG....GGlHshc	................chsph.sphhhDP+lsV-MsahGKGptsTNAt.GW.RssKhaapphhcp.pPE.haStpNpt+I.cpGh....sPllDppFlKHFPQY..sshhsDsLhHHHIGt.GGQAsAlPpsLHPGh...GGIHNhE.......	0	0	1	2
+15498	PF15638	Tox-MPTase2		Metallopeptidase toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	25.00	25.00	33.30	32.50	22.80	22.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.34	0.71	-4.78	6	10	2012-10-09 15:10:23	2012-10-09 16:10:23	1	2	9	0	2	10	0	186.80	24	14.59	NEW	DYFsssG+FI+ss.ps+ssNIYIpsssGN.llhSsYsh+.......pucNhQhhANIsuHYAKtlGlc.........ttsolGspu.tcpsspuchssss.pGtpIpsushNGahcphhsNhYNLpSTLtHEshHp..spRstsc.....scll+..Vlh+phps.cFu+TTpsF+puhAthhpchlpsAYtpssp..Ntshscs.Khlsphspssshphh	..........................DYFsspG+FI+ss.ps+ss.IYIppspsN.llhSphshp........tpshphhhpIshHYAptsGlp.........ttsslGssu.tspsspuphsAss.pstpIphtlpsGahs+phsNhYNLpSTLhHEshHp..ptRGssc.....scllc..Vlh+phcs.cFs+TTpsF+cupAshhpchLpphhtpssp..pthhtcs.chlst.thpss.ph..........................................	0	1	1	2
+15499	PF15639	Tox-MPTase3		Metallopeptidase toxin 3	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	25.00	25.00	26.50	157.80	23.60	20.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.86	0.71	-4.41	6	6	2012-10-09 15:10:47	2012-10-09 16:10:47	1	2	5	0	5	6	1	138.70	31	33.31	NEW	pt+KYP+LsaYLKasls..sl.l+sPsllpAhtKhutlscuplp-uLsWGKGPpIpIsshss......................AhGthoPsppuppl.pIctcLVspaEpups.c..pththallttTlLHELlHWuccpsGlD.PGEE.......GctFEc.lYGp	..t+KYP+LsaYLKasls..sl.l+sPsllpAhtKhutlscuplp-uLsWGKGPpIpIsshss......................AhGthoPsppuppl.pIctcLVspaEpups.c..pththallttTlLHELlHWuccpsGlD.PGEE.......GctFEc.lYGp.	0	1	5	5
+15500	PF15640	Tox-MPTase4		Metallopeptidase toxin 4	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	25.00	25.00	31.90	31.80	24.90	24.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.64	0.71	-4.51	7	110	2012-10-09 15:11:08	2012-10-09 16:11:08	1	13	105	0	3	60	0	125.40	78	16.88	NEW	-th.VSGQs.+ls.sGpRlhslp-hKsa+K-MsphGIKV.IDKKspIL.....PpssAuGFDPhTGcIhLRpcsohlsshHEshHAcQWhcLGKEsYhpQotLEREEaVaNEIMKNKthFscuEIhaup+YIapLRst	..........DGRRVSGHTGFL..DGVRLSR.SQINNIAKEMEKLGIKV.IRKADKYL.....PPNARAAFDYGLRNIYLRKNATLYEVYHEVIHAKQFAKIGREAYEALGRLSR..........EEHVLNEILKSK...NLFNEAEIAHAIKYVEGLREK...	0	1	2	2
+15501	PF15641	Tox-MPTase5		Metallopeptidase toxin 5	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	107.40	107.40	190.70	189.70	25.20	18.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.35	0.72	-4.08	5	5	2012-10-09 15:11:30	2012-10-09 16:11:30	1	3	3	0	1	4	0	109.20	79	12.30	NEW	DLGHVTGSTARARNKEITAILKEDFAYLKLTYIPQYNPFMRTGIAKLGEGTQFGKNSFSSRAELRDVIIHEELHHRWWKRGLNDHHPK.GTEMEQKFYETIRRYKRMRGW	DLGHVTGSTARARNKEITAILKEDFAYLKLTYIPQYNPFMRTGIAKLGEGTQFGKNSFSSRAELRDVIIHEELHHRWWKRGLNDHHPK.GTEMEQKFYETIRRYKRMRGW	0	0	1	1
+15502	PF15642	Tox-ODYAM1		Toxin in Odyssella and Amoebophilus	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted all-alpha fold toxin present in bacterial polymorphic toxin systems of the endosymbionts Odyssella and Amoebophilus [1].	25.00	25.00	665.80	665.80	23.20	21.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.22	0.70	-5.80	3	3	2012-10-09 16:09:44	2012-10-09 17:09:44	1	3	1	0	3	4	0	385.30	52	22.38	NEW	LKEHFKTtAoQuo.GAWKAulPV..KDI-psLSlpEQcALQQADKIVLDYNAKYpQsVp.NLSRFS+uKQQFSKAFuKTAQVoKDAVLGP-INSLp+LQQcVNuAYGSEVlKLDpGRhERNHcERps-lTTSHQQ+EEuLE+K+-cISuQL+..lsP++RlEL++cpspLssQLtEEEElYclALKRLsNPAQoALEDFYDWKRSVFHDFTKLHLGNaLITYEALALGTVARHPEAYEpsLQGSTAIGSVLADAFLPLGGLLGNVIGKIAEcGAELYADKQIRIKAAKIGSLYGHKGLEGMVALTREVANGLLFRLKDVIIDLTPESLDKLAKVATTQMIDYALKh..WEcNs.sQTINAhNLLL+GTQHQPSWhKuFTQsssLEpEDGRaVDG	LKEHFKTtAoQuo.GAWKAulPV..KDI-psLSlpEQcALQQADKIVLDYNAKYpQsVp.NLSRFS+uKQQFSKAFuKTAQVoKDAVLGP-INSLp+LQQcVNuAYGSEVlKLDpGRhERNHcERps-lTTSHQQ+EEuLE+K+-cISuQL+..lsP++RlEL++cpspLssQLtEEEElYclALKRLsNPAQoALEDFYDWKRSVFHDFTKLHLGNaLITYEALALGTVARHPEAYEpsLQGSTAIGSVLADAFLPLGGLLGNVIGKIAEcGAELYADKQIRIKAAKIGSLYGHKGLEGMVALTREVANGLLFRLKDVIIDLTPESLDKLAKVATTQMIDYALKh..WEcNs.sQTINAhNLLL+GTQHQPSWhKuFTQsssLEpEDGRaVDG	0	3	3	3
+15503	PF15643	Tox-PL-2		Papain fold toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A papain fold toxin domain found in bacterial polymorphic toxin systems [1]. 	25.00	25.00	26.00	90.80	24.00	23.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.37	0.72	-4.03	10	11	2012-10-09 16:10:18	2012-10-09 17:10:18	1	3	9	0	4	16	0	98.80	33	18.26	NEW	s.spl+QtIusIusc.F.p..laQChcCApAlcpaLppptIsGKlI+LpTt.spssa..Ias-tl..p...poIopNGpH.GItVt....shVFDNlascGlsRc-Wlpshps	....spltQtIspIssp.a.t..lhpC.pCApAltpaLppptIpGKlIcLpTt.pptsa..Ihs-tl..p...poIopNGpH.GltVt....shVFDNlpspGlsRc-Wlpsht...	0	1	4	4
+15504	PF15644	Tox-PL		Papain fold toxin 1	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A papain fold toxin domain found in bacterial polymorphic toxin systems. In these systems they might function either as a releasing peptidase or toxin [1].	24.10	24.10	24.50	24.10	23.40	22.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.64	0.72	-3.32	46	104	2012-10-09 16:13:10	2012-10-09 17:13:10	1	16	86	1	28	91	0	112.80	19	12.33	NEW	pNChsCslAstssht..GtshsAtPph.tt..................sppsshshhpphhu..............tp.ht.h...................sshptltptlpstspGupullhsph.............tsts......GHshsll..ppsGs..lhalDsQsGpss	........................................................NC.sCshuhthpht..GhshpAtsth.t...................stpsshshhpphhu..............t...h......................sstphhpphlpshspGutshlhhth..............tsts........uHshssh..hpsGp..lhalDsQsGp..h......	0	11	22	26
+15505	PF15645	Tox-PLDMTX		Dermonecrotoxin of the Papain-like fold	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A papain fold toxin domain found in bacterial polymorphic toxin systems [1]. 	26.10	26.10	26.80	27.00	20.70	25.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-11.04	0.71	-4.12	14	38	2012-10-09 16:45:02	2012-10-09 17:45:02	1	5	35	0	8	29	1	134.70	47	14.49	NEW	ssPhspCcsuhp.lsshh+.ptsh..psl+htslhh......W.psu...sc-hshNHalVlu+hsshcYVhDsTAcQFpsht................sp..sPlltstssWh.t...+aptuhpcKhlhhtchss...sphutssapt..t...hss.cslpssphLspPpWY	..............h.NPlGQCESLMTPVSsFMp.-KGF..-NIRYRGIaI......W..Dcs...TEElPpNHFAVVGsK-GKDYVFDlSAHQFcN+Gh...............SsLsGPLILoAD-Wls....KYRh..Ao++KLIhYsDFuN...uulAusuacALsc...chpsEohsGclhlTSPRWF.......................................	0	1	4	6
+15506	PF15646	Tox-REase-2		Restriction endonuclease fold toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 7 or PrsW-peptidase dependent secretion system [1].	67.30	67.30	109.90	109.20	25.30	21.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.60	0.71	-4.25	7	7	2012-10-09 16:47:01	2012-10-09 17:47:01	1	2	6	0	4	7	0	127.40	32	25.86	NEW	spsAYQhclAGYPEhclslP...upcpslhsDGhRsp...DGhhl-AKaVscPspsph..........p.lcplchpppupht.....DhhhcpDccELp+YstAhsss.spph+GlEIVTNs..................-ussYWpshMAhhGVs	spsAYQhclAGYPEhclslP...upcpslhsDGhRsp...DGhhl-AKaVscPspsph..........p.lcplchpppupht.....DhhhcpDccELp+YstAhsss.spph+GlEIVTNs..................-ussYWpshMAhhGVs	0	1	2	4
+15507	PF15647	Tox-REase-3		Restriction endonuclease fold toxin 3	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or PrsW-peptidase dependent secretion system [1].	25.00	25.00	36.00	68.00	22.20	20.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.19	0.72	-4.25	5	39	2012-10-09 16:47:57	2012-10-09 17:47:57	1	7	38	0	3	32	0	108.70	62	15.12	NEW	puuKh+sstscpYEDhlREKLGGpS+lltu.....REaDAVTDchlAQsKcolSuIcpPKNFLNKKsRcQIKATIEAApQQGK+ApFWFKhc....VpscV+EYIEp+GGcVIIsocs	........ppuKhREALDlHYEDLlRRKLGG.Sp.IsG.....REaDsVTDchIAQsKRThSuIDpPKNFLsKpsRsQIKtTIEhAcpQGKcApFWFKYG....VpsKV+EYIESKGGcVllGhG.s	0	1	2	2
+15508	PF15648	Tox-REase-5		Restriction endonuclease fold toxin 5	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or PrsW-peptidase dependent secretion system. Versions of this domain are also found in caudoviruses [1].	25.00	25.00	34.30	33.40	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.38	0.72	-3.70	66	128	2012-10-09 16:49:27	2012-10-09 17:49:27	1	5	85	0	41	164	2	94.30	33	27.11	NEW	tshpYQtpITG.hs.......hshphtht..t.............................h.h.slcFDGapss...pslLhEAKu..sY.c.pFhc.pst...p.st.h.............hpuhcsh...hcQupcQspssps.t.s.splcWaFtp.	....shcYQtplTG.hs.......hsh.-.ht.hs...pp............................h.h.slcFDGFpss...cChLhEAKu..sY.c.pFhs.ssh...p..t.h.............hpGhpsh.hppApcQsssscs.s.sssplcWaFtp...........	0	3	9	21
+15509	PF15649	Tox-REase-7		Restriction endonuclease fold toxin 7	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or type 7 secretion system [1].	25.00	25.00	27.60	28.40	23.30	22.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.87	0.72	-3.85	21	52	2012-10-09 16:49:57	2012-10-09 17:49:57	1	10	43	0	15	60	0	86.20	34	11.40	NEW	tGptuEppss.sht.......tspcplsstss.......tpRIPDshsp.spplsEVKNVpcl..shopQl+s.sphApppGhphsLlVs..csTplS.psL	........................h.GctuEhtAuhhhs.......us++plssshs.tt....tppIPDhls..p.sc..slsEVKNVpc...uhTcQlptplchApp.thchhLlss..chTclst.........	0	4	9	14
+15510	PF15650	Tox-REase-9		Restriction endonuclease fold toxin 9	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system [1].	25.00	25.00	30.10	29.10	23.10	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.81	0.72	-3.78	11	16	2012-10-09 16:50:23	2012-10-09 17:50:23	1	7	15	0	9	17	0	83.00	43	6.76	NEW	thopSuh+hGRphHKsYKsu.h.....st.KEFpLPSG+RhD..FlDa-s..KhIYELKPsNP+uIKcGhKQLcsY+pElcphh........GtsWpslL-TY	.t.hopSuh+hGRphHKsYKhs.......shpKEF+LP..SGK..RhD..hlDhps..+hIYELKP.NP+uIKpGhKQLcsY+pElpph.........GtsWpshl-sY......	0	4	9	9
+15511	PF15651	Tox-SGS		Salivary glad secreted protein domain toxin	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	An alpha+beta fold domain with four conserved cysteine residues and a conserved [DE}xx[ND] motif. This domain is mainly present at the c-terminus of RHS repeats containing proteins in insects and crustaceans. Although no bacterial homologs have been identified, the domain architecture suggests an origin from bacterial polymorphic toxin systems [1]. 	25.00	25.00	29.20	27.80	18.20	17.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.35	0.72	-4.23	18	21	2012-10-09 16:50:45	2012-10-09 17:50:45	1	2	6	0	14	21	0	97.10	33	3.39	NEW	pNCa....ssss-tsplpCYppcupsplFs+ss........phhspDpassChPlpapGpPSluCcGppooalYTPhps....s+hFDhlDGWLhLApVuPsslRNlppsh	......................NCa....s.ssphshlhCapppuhshlFs+ss........pshspDpassChPlpapGpPSluCcGppooalYTPhps....schFDhlDGWLhLApVuPssl+slpph................	0	3	4	14
+15512	PF15652	Tox-SHH		HNH/Endo VII superfamily toxin with a SHH signature	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6 or type 7 secretion system [1].	22.70	22.70	23.80	24.60	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.63	0.72	-3.42	14	38	2012-10-09 16:51:09	2012-10-09 17:51:09	1	12	37	0	9	38	1	91.60	36	20.28	NEW	.suhlQSHHsIQDtWAc....pslssYspc..tAPshLl.Ssst.sHAtloA...tpRscRsupG......WsoslpcEFstuhpE.Mh-.AGVsppssc+sh+c..uY+YFD	...su.lpsHHul.DhWAc....pNlssYstc..tsssslh.otc...Hshhpss.pthhhc+sucs.sGK..Wpos.pcEhpphscc.Mh-.AsVscpstpphhcs..pYpah...	0	1	5	8
+15513	PF15653	Tox-URI2		URI fold toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the URI nuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1].	25.00	25.00	25.60	25.20	22.10	20.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-10.04	0.72	-3.79	13	44	2012-10-09 16:52:12	2012-10-09 17:52:12	1	9	34	0	16	47	0	76.20	23	13.91	NEW	.chupccshuYphhcKs-....laKlGEos.....ppps.sh+sRhstphLc+ssup...................hphlpcss....t..sKpsspphEst+lppapcppG	.......p.spcpshsYthhccss....lhKhGcos.....tpts.ssctRhphphLpcpssp...................hphhspss........s+pphpphEptclpth................	0	7	13	14
+15514	PF15654	Tox-WTIP		Toxin with a conserved tryptophan and TIP tripeptide motif	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin domain with two membrane spanning alpha helices and RxxR, Wx[ST]IP motifs. The domain is present in bacterial polymorphic toxin systems. The toxin is usually exported by the type 2 or Photorhabdus virulence cassette (PVC)-type secretion system [1].	25.00	25.00	81.00	79.70	21.00	19.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.82	0.72	-4.35	7	9	2012-10-09 16:52:36	2012-10-09 17:52:36	1	5	9	0	1	10	0	54.00	48	9.63	NEW	.phsssssshsss-sussssAusGsuYllYRslRhlPSLhPPLW.TIPANlAhP	.p.phssssoshoTs-sussssAslGsGYlIYRslRhlPSLhPPLWhoIPANlssP	0	0	0	1
+15515	PF15655	Imm-NTF2		NTF2 fold immunity protein	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein of the NTF2 fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-JAB-2 family [1].	25.00	25.00	27.70	27.40	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.00	0.71	-3.68	32	92	2012-10-09 18:50:36	2012-10-09 19:50:36	1	3	74	0	15	92	2	130.10	21	66.80	NEW	.ppscphlhs...FhttMppWEp...h.....ppht.pp.t.............hppclpsIappasTcK...pRptut....shSh...G.PspYs.ppt....hl-h..pptspsplhl.hp..pps...thptc.acahlhhpsscWhIDp....hppc........-pWppsh.	.............................................h...hpphl.tFhtthppaEt.h.......pt.s.pp......................t.hppclttlappaso-K....+htst...hshSa...u.supYss.p.....hl-h..cphscsclhlht..ppp....hphc.hpFlhhhhsspWhIDp....hppc........ctWpps..h.......	0	2	9	9
+15516	PF15656	Tox-HDC		Toxin with a H, D/N and C signature	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted alpha/beta fold peptidase domain with a strongly conserved triad of a histidine, aspartate/asparagine and cysteine residues that are predicted to comprise the active site of the predicted peptidase. Proteins bearing this predicted toxin domain are particularly common in both intracellular and extracellular pathogens [1].	25.00	25.00	28.30	27.40	20.40	19.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.73	0.71	-3.90	9	20	2012-10-09 19:11:59	2012-10-09 20:11:59	1	5	16	0	5	19	0	116.40	28	18.40	NEW	tlaGscsphtshc.lptslpsIs+p.S..spsIhIlSGoHGhssG.........pNWhtps.........lRcPpl.h-hpFhtpDhpshpt....hscplhlhDlssss.tchss..lpss......ssphILuYCaStsDpsht.	.........................lhstptth.sht.lptshphlt+p.s.sstcIhIlSGoHGtssG.........pNasups...............lRcPsl.hE+tFahEDlpsap.t...........hstpV+lhDlushop.pEhss.plpss......spplIhGaCaSpsDchhh.h....	0	1	2	4
+15517	PF15657	Tox-HNH-EHHH		HNH/Endo VII superfamily nuclease toxins	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic conserved [ED]H motif and two histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system [1].	25.00	25.00	26.70	26.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.70	0.72	-3.83	33	80	2012-10-09 19:15:32	2012-10-09 20:15:32	1	26	69	0	26	75	0	66.90	30	8.65	NEW	tlhcpsspshhsRpYcFpsscG.....ppllIp-HotGHths.....tspsPHFNsts.cs...........................hpsGphsspcsHYsa	.......hhsspspshhsR.acapshcG.........pKhlIp-HotG+th.......spuPHapsts.pp............................h.c.puphstp.psHY.a.......................	0	2	9	18
+15518	PF15658	Latrotoxin_C		Latrotoxin C-terminal domain	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A toxin domain present in arthropod alphaproteobacterial, gammaproteobacterial endosymbionts and also at the C-termini of the latrotoxins of the black widow spider. The domain is characterized by a conserved, hydrophobic helix and is predicted to associate with the cell membrane [1].	25.00	25.00	46.20	43.40	24.70	22.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.46	0.71	-4.31	8	23	2012-10-09 19:27:40	2012-10-09 20:27:40	1	16	8	0	8	25	0	126.00	38	6.65	NEW	phDsNuslhLLDlLIRKlTspKYhsT....sc.polSPLEApGYALsIsKcFEcVlc.QAulKSGISh+cLNIDhlElQcpIssK..ItSGKFsEISulLsSYlEcAhPs......ucLS.Kph-KFhspFNscl-.....slLNp	......hDVNGslhLLDlLIRKhoupKYhss....sc....pSISsLEAQuYALsIsc+FEcVLp.psulKuGlShcpLNlDhstlQpcIhtK..lhuG+FsEIuthLsSasccAhPt......upLp.KphcKFh.pFppthc.hlp.............	0	0	2	2
+15519	PF15659	Toxin-JAB1		JAB-like toxin  1	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	\N	26.40	26.40	26.40	26.60	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.36	0.71	-4.36	13	24	2012-10-10 14:49:21	2012-10-09 20:38:55	1	2	16	0	6	24	1	153.20	26	34.55	NEW	p+ss+las....phtsusps-phhssp.ts..psIpl.spsll...uphsp..tpsppG....thpoas....oTssspsAtslFcFsA-NTo..VEWpLsshp.-sGs.pshsltTspcptuspss..hsph.pc.htssuphlhc..IHSH...........Ptss.....tsS.....hsDhphup.tps..........huhYhpc.......tthhphYs	......................ppssclhp.....hhpssps-phh.hp.ts..psIpl.sppll...sthhp..tpsppG....hhpoas....sTss.csAtslFcFsA-NTo..VEWpLssht.-p....Gs.pshhlsTsppppuVt....hs.htpc.h.stsphlIc..hHSH...........Phss....tsS.....spDhpshp.hps...........shahcc........t.h..Y................	0	6	6	6
+15520	PF15660	Imm49		Immunity protein 49	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	\N	25.00	25.00	168.90	168.80	24.80	19.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.79	0.72	-3.94	4	10	2012-10-09 20:02:34	2012-10-09 21:02:34	1	1	10	0	0	10	0	82.90	99	96.96	NEW	hRALVALKRELLPGVTTFIDSVRLEAIDDKADRLMVTTSVGEEARLVYFNPDFAGTPTFGRRLYRLRDWTDDLADWVDRLRRER	VRALVALKRELLPGVTTFIDSVRLEAIDDKADRLMVTTSVGEEARLVYFNPDFAGTPTFGRRLYRLRDWTDDLADWVDRLRRER	0	0	0	0
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/pfamA.txt.gz
Binary file pfam_annot/pfamA.txt.gz has changed
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/pfam_annot.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/pfam_annot.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,13 @@
+<tool id="pfam_Annot" name="PFAM output annotator" version="0.">
+ <description>Generate synthetic reports</description>
+ <command> /home/inmare/galaxy/tools/pfam_annot/annota.pl $prot $pfam $out</command>
+ <inputs>
+ 	<param name="prot" type="data" format="fasta" label="protein file used as input with pfamScan" help="fasta only"/>
+ 	<param name="pfam" type="data" format="tabular" label="pfamScan output" help="this file should match the protein file"/>
+ </inputs>
+ <outputs>
+ 	<data name="out" ftype="tabular" format="html" label="annotated pfam file"/>
+ </outputs>
+ <test/>
+ <help> This tools produce a synthetic report, in fasta format, containing a description of PFAM domains annotated to each protein. A separate report is generated for each fosmid. Fosmid names are inferred from the heades of the input fasta file, using the naming convention described in the "Sanger Fosmid End" annotator tool.  Therefore contigs should be assigned to fosmids prior to perform this step and ideally prior to the annotation of functional domains. The output file contains links to the PFAM wiki, where a more comprehensive description of the domains can be found. A pfamScan output table is required as input.  The output of this tool is compatible with the PFAM search utility, which might be used in order to perform keyword searches on the annotation  </help>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/pro
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/pro	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,646 @@
+<html>
+<head></head>
+<body>
+Proteins with PFAM domains:
+<br><br>
+<div>
+<table cellpadding="0" width=650>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00001</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSAQRLGFSLDEIAELLRLDDGTHCEEASSLAE
+HKLKDVREKMADLARMETVLSELVCACHARKGNVSCPLIASLQGEAGLARSAMP
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00376> PF00376</a>
+<p align="justify">merR; <br>MerR family regulatory protein. Prosite & Pfam-B_3021 (Release 7.5). </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF09278> PF09278</a>
+<p align="justify">MerR, DNA binding<br>Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold  .. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00002</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTVLEPYRPLFIGAALVALFFAWKRIYRPVQACKPGEVCAIPQVRAT
+YKLIFWIVAVLVLVALGFPYVVPFFY
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02411> PF02411</a>
+<p align="justify">MerT mercuric transport protein<br>Pfam-B_1796 (release 5.4). MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic  MerP (also part of the transport system) to mercuric reductase (MerE).. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00003</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKREAVVTFDDTKASVQKLTKATADAGYPSSVK
+Q
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>
+<p align="justify">Heavy-metal-associated domain<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00004</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQYEGLFISRLLPLFAALAFLANALGWFSHRQWLRSLLGMIGPAIVFA
+ATVWLLGNWWTANLMYVGLALMIGVSIWDFVSPAHRRCGPDGCELPAKRL
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03203> PF03203</a>
+<p align="justify">MerC mercury resistance protein<br>Pfam-B_2720 (release 6.5). </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00005</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIEVGTSPDALTAAVAGLGYRATLADAPSVSTPGGLLDKMRDLLGRND
+KTGSSGALHIAVIGSGGAAMAAALKAVEQGARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIAATTPTIQRTALLAQ
+QQARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQLNDGGERVVAFDRCLIATGASPAVPPIPGLKDTPYWTSTEALVSETIPK
+RLAVIGSSVVALELAQAFARLGAKVTILARSTLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYINGEGDGEFVLTTAHGELRADKL
+LVATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVEHIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALNLTAMPAVVFTDPQV
+ATVGYSEAEAHHDGIKTDSRTLTLDNVPRALANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLT
+MVEGLKLAAQTFNKDVKQLSCCAG
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>
+<p align="justify">Heavy-metal-associated domain<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF07992> PF07992</a>
+<p align="justify">Pyridine nucleotide-disulphide oxidoreductase<br>This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a>
+ <p align="justify">FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site  .  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00070> PF00070</a>
+<p align="justify">pyr_redox; <br>Pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a>
+ <p align="justify">FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site  .  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02852> PF02852</a>
+<p align="justify">pyr_redox_dim; <br>Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00006</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDAALQRLCFVRAAFEAGIGLDALARLCRALDAADGAQAAAQLAVLRQ
+LVERRRAALAHLDAQLASMPAERAHEEALP
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13411> PF13411</a>
+<p align="justify">MerR HTH family regulatory protein<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00007</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+VNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAGAFLGEHWGVAALALTGLFVLAVTRLLRAFRGGS
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF05052> PF05052</a>
+<p align="justify">MerE protein<br>Pfam-B_5840 (release 7.7). The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2]. . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00008</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALMRWRHPRLGLLPPGQFLPLAESFGLMPEIGAWVLGEACRQMHKWQG
+PAWQPFRLAINVSASQVGPTFDDEVKRVLADMALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDFGTGYSCLQHLKCCPITT
+LKIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLHQLIGRNGCCAASS
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00563> PF00563</a>
+<p align="justify">DUF2; <br>Alignment kindly provided by SMART. This domain is found in diverse bacterial signaling proteins.  It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function  . The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site  .. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00009</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVYVLIRRARQGSGLVTDLVPGQSGGGKGKGRL
+PEPVERVIHELLQKRFLTKQKRSLAAFHREVTQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQV
+QIDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVACDKRPWLEGLNVEMDWQMSGKPLLLYLDNAA
+EFKSEALRRGCEQHGIRLDYRPLGQPHYGGIVERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVH
+NGLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHCCK
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13518> PF13518</a>
+<p align="justify">Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00665> PF00665</a>
+<p align="justify">Integrase core domain<br>Pfam-B_10 (release 2.1). Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site  .. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a>
+ <p align="justify">Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00010</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHSTIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAY
+LYRAVDSRGRTVDFYLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHRQIKYRNNVIECDHGKLK
+RIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPLGEMRLVSRVFEM
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13610> PF13610</a>
+<p align="justify">DDE domain<br>This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a>
+ <p align="justify">Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00011</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00126> PF00126</a>
+<p align="justify">Bacterial regulatory helix-turn-helix protein, lysR family<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00013</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFTFDASLQSLLMLTFFSSIGLSSDFSRLIKGG
+KPLVLLTIAVTILIAIQNTVGMSMAVMMNESPFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVAR
+HLLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKDTFLQLPTFVWCLFVGIIIRNTLTHVFKHEV
+FEPTVDVLGSVALSLFLAMALMSLKFGQLASMAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTV
+TKAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03616> PF03616</a>
+<p align="justify">Sodium/glutamate symporter<br>TIGRFAMs, Griffiths-Jones SR. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0064> CL0064</a>
+ <p align="justify">CPA/AT transporter superfamily This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB  . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00014</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLATEGKMLSLSWWENEYAVLQWKNHVLHAKAQQEGRESIFDFYKISI
+AHITREYSFKKDKDNV
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03992> PF03992</a>
+<p align="justify">Antibiotic biosynthesis monooxygenase<br>This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is  suggestive that the other proteins function as  multimers. There is also a conserved histidine which is likely to be an active site residue.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0032> CL0032</a>
+ <p align="justify">Dimeric alpha/beta barrel superfamily This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel.  The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00015</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHFLVEQGKEAKIALEQAGLLVLAIRTPLIRKLKQEKPGELGEIARVL
+AENNINILVQYSDHANQLILITDNDSMAASVTLPWAIK
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01842> PF01842</a>
+<p align="justify">ACT domain<br>This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.  The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine  . Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0070> CL0070</a>
+ <p align="justify">These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains  . The relationship between these two families was first noticed in  . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00016</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESMMGISLNHGVHARVSTPV
+HLRKARTCYDHLAGEVAVKIYDSLCQQQWITENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKG
+WLTRHLGYREVTITEKGYAAFKTHFHI
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF12840> PF12840</a>
+<p align="justify">Helix-turn-helix domain<br>This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00017</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCAL
+LSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQ
+GAEPAFLFGLELIICGLEKQLKCESGS
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00440> PF00440</a>
+<p align="justify">tetR; <br>Bacterial regulatory proteins, tetR family. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02909> PF02909</a>
+<p align="justify">tetR_C; <br>Tetracyclin repressor, C-terminal all-alpha domain. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0174> CL0174</a>
+ <p align="justify">TetR protein, C-terminal domain-like This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4]. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/prots
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/prots	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,80 @@
+>PROKKA_00001 Mercuric resistance operon regulatory protein
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSA
+QRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHAR
+KGNVSCPLIASLQGEAGLARSAMP*
+>PROKKA_00002 MerT mercuric transport protein
+MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTVLEPYRPLFIGAALV
+ALFFAWKRIYRPVQACKPGEVCAIPQVRATYKLIFWIVAVLVLVALGFPYVVPFFY*
+>PROKKA_00003 Mercuric transport protein periplasmic component precursor
+MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKR
+EAVVTFDDTKASVQKLTKATADAGYPSSVKQ*
+>PROKKA_00004 Mercuric resistance protein MerC
+MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQYEGLFISRLLPLFAAL
+AFLANALGWFSHRQWLRSLLGMIGPAIVFAATVWLLGNWWTANLMYVGLALMIGVSIWDF
+VSPAHRRCGPDGCELPAKRL*
+>PROKKA_00005 Mercuric reductase
+MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIEVGTSPDALTAAVAGL
+GYRATLADAPSVSTPGGLLDKMRDLLGRNDKTGSSGALHIAVIGSGGAAMAAALKAVEQG
+ARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIAATTPTIQRTALLAQ
+QQARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQLNDGGERVVAFDRCLIATG
+ASPAVPPIPGLKDTPYWTSTEALVSETIPKRLAVIGSSVVALELAQAFARLGAKVTILAR
+STLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYINGEGDGEFVLTTAHGELRADKL
+LVATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVEHIYAAGDCTDQPQFVYVAAAA
+GTRAAINMTGGDAALNLTAMPAVVFTDPQVATVGYSEAEAHHDGIKTDSRTLTLDNVPRA
+LANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLT
+MVEGLKLAAQTFNKDVKQLSCCAG*
+>PROKKA_00006 zinc-responsive transcriptional regulator
+MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDAALQRLCFVRAAFEAG
+IGLDALARLCRALDAADGAQAAAQLAVLRQLVERRRAALAHLDAQLASMPAERAHEEALP
+*
+>PROKKA_00007 MerE protein
+VNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAGAFLGEHWGVAALALT
+GLFVLAVTRLLRAFRGGS*
+>PROKKA_00008 Phytochrome-like protein cph2
+MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALMRWRHPRLGLLPPGQF
+LPLAESFGLMPEIGAWVLGEACRQMHKWQGPAWQPFRLAINVSASQVGPTFDDEVKRVLA
+DMALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDFGTGYSCLQHLKCCPITT
+LKIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLHQLIGRNGCCAASS*
+>PROKKA_00009 Transposon Tn7 transposition protein TnsB
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVY
+VLIRRARQGSGLVTDLVPGQSGGGKGKGRLPEPVERVIHELLQKRFLTKQKRSLAAFHRE
+VTQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQV
+QIDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVAC
+DKRPWLEGLNVEMDWQMSGKPLLLYLDNAAEFKSEALRRGCEQHGIRLDYRPLGQPHYGG
+IVERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVH
+NGLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHC
+CK*
+>PROKKA_00010 Integrase core domain protein
+MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHSTIYRWVQRYAPEMEK
+RLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDFYLSSRRNSKAAYRFLG
+KILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHRQIKYRNNVIECDHGKLK
+RIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPLGEMRLVSRVFEM*
+>PROKKA_00011 DNA-binding transcriptional regulator LysR
+MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH*
+>PROKKA_00012 hypothetical protein
+MPSRFLTPYIPLVNLFSLHVYELILVTTKPKFEL*
+>PROKKA_00013 Sodium/glutamate symport carrier protein
+MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFT
+FDASLQSLLMLTFFSSIGLSSDFSRLIKGGKPLVLLTIAVTILIAIQNTVGMSMAVMMNE
+SPFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVAR
+HLLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKD
+TFLQLPTFVWCLFVGIIIRNTLTHVFKHEVFEPTVDVLGSVALSLFLAMALMSLKFGQLA
+SMAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTV
+TKAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT*
+>PROKKA_00014 Antibiotic biosynthesis monooxygenase
+MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLATEGKMLSLSWWENEY
+AVLQWKNHVLHAKAQQEGRESIFDFYKISIAHITREYSFKKDKDNV*
+>PROKKA_00015 hypothetical protein
+MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHFLVEQGKEAKIALEQA
+GLLVLAIRTPLIRKLKQEKPGELGEIARVLAENNINILVQYSDHANQLILITDNDSMAAS
+VTLPWAIK*
+>PROKKA_00016 Helix-turn-helix domain protein
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFR
+LAGKDIAELMESMMGISLNHGVHARVSTPVHLRKARTCYDHLAGEVAVKIYDSLCQQQWI
+TENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKG
+WLTRHLGYREVTITEKGYAAFKTHFHI*
+>PROKKA_00017 Tetracycline repressor protein class B from transposon Tn10
+MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEML
+DRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFL
+CQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQ
+GAEPAFLFGLELIICGLEKQLKCESGS*
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/prova
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/prova	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,536 @@
+<html>
+<head></head>
+<body>
+Proteins with PFAM domains:
+<br><br>
+<div>
+<table cellpadding="0" width=950>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00001</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSAQ<br>RLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHARK<br>GNVSCPLIASLQGEAGLARSAMP*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00376> PF00376</a>merR; <br>MerR family regulatory protein Prosite & Pfam-B_3021 (Release 7.5) 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF09278> PF09278</a>MerR, DNA binding<br>Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00002</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTVLEPYRPLFIGAALVA<br>LFFAWKRIYRPVQACKPGEVCAIPQVRATYKLIFWIVAVLVLVALGFPYVVPFFY*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02411> PF02411</a>MerT mercuric transport protein<br>MerT mercuric transport protein MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic  MerP (also part of the transport system) to mercuric reductase (MerE). 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00003</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKRE<br>AVVTFDDTKASVQKLTKATADAGYPSSVKQ*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>Heavy-metal-associated domain<br>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00004</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQYEGLFISRLLPLFAALA<br>FLANALGWFSHRQWLRSLLGMIGPAIVFAATVWLLGNWWTANLMYVGLALMIGVSIWDFV<br>SPAHRRCGPDGCELPAKRL*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03203> PF03203</a>MerC mercury resistance protein<br>MerC mercury resistance protein 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00005</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIEVGTSPDALTAAVAGLG<br>YRATLADAPSVSTPGGLLDKMRDLLGRNDKTGSSGALHIAVIGSGGAAMAAALKAVEQGA<br>RVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIAATTPTIQRTALLAQQ<br>QARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQLNDGGERVVAFDRCLIATGA<br>SPAVPPIPGLKDTPYWTSTEALVSETIPKRLAVIGSSVVALELAQAFARLGAKVTILARS<br>TLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYINGEGDGEFVLTTAHGELRADKLL<br>VATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVEHIYAAGDCTDQPQFVYVAAAAG<br>TRAAINMTGGDAALNLTAMPAVVFTDPQVATVGYSEAEAHHDGIKTDSRTLTLDNVPRAL<br>ANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTM<br>VEGLKLAAQTFNKDVKQLSCCAG*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>Heavy-metal-associated domain<br>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF07992> PF07992</a>Pyridine nucleotide-disulphide oxidoreductase<br>Pyridine nucleotide-disulphide oxidoreductase This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a> FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site  .  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00070> PF00070</a>pyr_redox; <br>Pyridine nucleotide-disulphide oxidoreductase Sonnhammer ELL, Griffiths-Jones SR This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a> FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site  .  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02852> PF02852</a>pyr_redox_dim; <br>Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00006</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDAALQRLCFVRAAFEAGI<br>GLDALARLCRALDAADGAQAAAQLAVLRQLVERRRAALAHLDAQLASMPAERAHEEALP*<br>
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13411> PF13411</a>MerR HTH family regulatory protein<br>MerR HTH family regulatory protein 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00007</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+VNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAGAFLGEHWGVAALALTG<br>LFVLAVTRLLRAFRGGS*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF05052> PF05052</a>MerE protein<br>The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2].  
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00008</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALMRWRHPRLGLLPPGQFL<br>PLAESFGLMPEIGAWVLGEACRQMHKWQGPAWQPFRLAINVSASQVGPTFDDEVKRVLAD<br>MALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDFGTGYSCLQHLKCCPITTL<br>KIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLHQLIGRNGCCAASS*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00563> PF00563</a>DUF2; <br>Alignment kindly provided by SMART This domain is found in diverse bacterial signaling proteins.  It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function  . The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00009</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVYV<br>LIRRARQGSGLVTDLVPGQSGGGKGKGRLPEPVERVIHELLQKRFLTKQKRSLAAFHREV<br>TQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQVQ<br>IDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVACD<br>KRPWLEGLNVEMDWQMSGKPLLLYLDNAAEFKSEALRRGCEQHGIRLDYRPLGQPHYGGI<br>VERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVHN<br>GLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHCC<br>K*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13518> PF13518</a>Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00665> PF00665</a>Integrase core domain<br>Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a> Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00010</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHSTIYRWVQRYAPEMEKR<br>LRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDFYLSSRRNSKAAYRFLGK<br>ILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHRQIKYRNNVIECDHGKLKR<br>IIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPLGEMRLVSRVFEM*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13610> PF13610</a>DDE domain<br>This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a> Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00011</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00126> PF00126</a>Bacterial regulatory helix-turn-helix protein, lysR family<br>Bacterial regulatory helix-turn-helix protein, lysR family 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00013</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFTF<br>DASLQSLLMLTFFSSIGLSSDFSRLIKGGKPLVLLTIAVTILIAIQNTVGMSMAVMMNES<br>PFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVARH<br>LLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKDT<br>FLQLPTFVWCLFVGIIIRNTLTHVFKHEVFEPTVDVLGSVALSLFLAMALMSLKFGQLAS<br>MAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTVT<br>KAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03616> PF03616</a>Sodium/glutamate symporter<br>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0064> CL0064</a> CPA/AT transporter superfamily This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00014</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLATEGKMLSLSWWENEYA<br>VLQWKNHVLHAKAQQEGRESIFDFYKISIAHITREYSFKKDKDNV*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03992> PF03992</a>Antibiotic biosynthesis monooxygenase<br>Antibiotic biosynthesis monooxygenase This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is  suggestive that the other proteins function as  multimers. There is also a conserved histidine which is likely to be an active site residue. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0032> CL0032</a> Dimeric alpha/beta barrel superfamily This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel.  The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00015</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHFLVEQGKEAKIALEQAG<br>LLVLAIRTPLIRKLKQEKPGELGEIARVLAENNINILVQYSDHANQLILITDNDSMAASV<br>TLPWAIK*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01842> PF01842</a>ACT domain<br>This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.  The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine  . Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0070> CL0070</a> These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains  . The relationship between these two families was first noticed in  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00016</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRL<br>AGKDIAELMESMMGISLNHGVHARVSTPVHLRKARTCYDHLAGEVAVKIYDSLCQQQWIT<br>ENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKGW<br>LTRHLGYREVTITEKGYAAFKTHFHI*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF12840> PF12840</a>Helix-turn-helix domain<br>This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00017</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLD<br>RHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLC<br>QQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQG<br>AEPAFLFGLELIICGLEKQLKCESGS*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00440> PF00440</a>tetR; <br>Bacterial regulatory proteins, tetR family 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02909> PF02909</a>tetR_C; <br>Tetracyclin repressor, C-terminal all-alpha domain 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0174> CL0174</a> TetR protein, C-terminal domain-like This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4]. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+</table>
+</div>
+</body>
+</html>
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/prova2
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/prova2	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,660 @@
+<html>
+<head>
+<style type="text/css">
+span {
+	text-decoration:underline;
+	color:blue;
+	cursor:pointer;
+}
+</style>
+<script src="script.js"></script>
+<script>
+	show(elementID)
+</script>
+</head>
+Proteins with PFAM domains:
+<br><br>
+<div>
+<table cellpadding="0" width=650>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00001</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSAQRLGFSLDEIAELLRLDDGTHCEEASSLAE
+HKLKDVREKMADLARMETVLSELVCACHARKGNVSCPLIASLQGEAGLARSAMP
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00376> PF00376</a>
+<p align="justify">merR; <br>MerR family regulatory protein Prosite & Pfam-B_3021 (Release 7.5) </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF09278> PF09278</a>
+<p align="justify">MerR, DNA binding<br>Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00002</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTVLEPYRPLFIGAALVALFFAWKRIYRPVQACKPGEVCAIPQVRAT
+YKLIFWIVAVLVLVALGFPYVVPFFY
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02411> PF02411</a>
+<p align="justify">MerT mercuric transport protein<br>Pfam-B_1796 (release 5.4) MerT is an mercuric transport integral membrane protein and is responsible for transport of the Hg2+ iron from periplasmic MerP (also part of the transport system) to mercuric reductase (MerE). </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00003</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKREAVVTFDDTKASVQKLTKATADAGYPSSVK
+Q
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>
+<p align="justify">Heavy-metal-associated domain<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00004</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQYEGLFISRLLPLFAALAFLANALGWFSHRQWLRSLLGMIGPAIVFA
+ATVWLLGNWWTANLMYVGLALMIGVSIWDFVSPAHRRCGPDGCELPAKRL
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03203> PF03203</a>
+<p align="justify">MerC mercury resistance protein<br>Pfam-B_2720 (release 6.5) </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00005</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIEVGTSPDALTAAVAGLGYRATLADAPSVSTPGGLLDKMRDLLGRND
+KTGSSGALHIAVIGSGGAAMAAALKAVEQGARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIAATTPTIQRTALLAQ
+QQARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQLNDGGERVVAFDRCLIATGASPAVPPIPGLKDTPYWTSTEALVSETIPK
+RLAVIGSSVVALELAQAFARLGAKVTILARSTLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYINGEGDGEFVLTTAHGELRADKL
+LVATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVEHIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALNLTAMPAVVFTDPQV
+ATVGYSEAEAHHDGIKTDSRTLTLDNVPRALANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLT
+MVEGLKLAAQTFNKDVKQLSCCAG
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>
+<p align="justify">Heavy-metal-associated domain<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF07992> PF07992</a>
+<p align="justify">Pyridine nucleotide-disulphide oxidoreductase<br>This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a>
+ <p align="justify">FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme. The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction. Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site . In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00070> PF00070</a>
+<p align="justify">pyr_redox; <br>Pyridine nucleotide-disulphide oxidoreductase This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a>
+ <p align="justify">FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme. The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction. Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site . In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02852> PF02852</a>
+<p align="justify">pyr_redox_dim; <br>Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00006</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDAALQRLCFVRAAFEAGIGLDALARLCRALDAADGAQAAAQLAVLRQ
+LVERRRAALAHLDAQLASMPAERAHEEALP
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13411> PF13411</a>
+<p align="justify">MerR HTH family regulatory protein<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00007</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+VNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAGAFLGEHWGVAALALTGLFVLAVTRLLRAFRGGS
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF05052> PF05052</a>
+<p align="justify">MerE protein<br>Pfam-B_5840 (release 7.7) The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2]. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00008</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALMRWRHPRLGLLPPGQFLPLAESFGLMPEIGAWVLGEACRQMHKWQG
+PAWQPFRLAINVSASQVGPTFDDEVKRVLADMALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDFGTGYSCLQHLKCCPITT
+LKIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLHQLIGRNGCCAASS
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00563> PF00563</a>
+<p align="justify">DUF2; <br>Alignment kindly provided by SMART This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function . The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00009</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVYVLIRRARQGSGLVTDLVPGQSGGGKGKGRL
+PEPVERVIHELLQKRFLTKQKRSLAAFHREVTQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQV
+QIDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVACDKRPWLEGLNVEMDWQMSGKPLLLYLDNAA
+EFKSEALRRGCEQHGIRLDYRPLGQPHYGGIVERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVH
+NGLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHCCK
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13518> PF13518</a>
+<p align="justify">Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00665> PF00665</a>
+<p align="justify">Integrase core domain<br>Pfam-B_10 (release 2.1) Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a>
+ <p align="justify">Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00010</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHSTIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAY
+LYRAVDSRGRTVDFYLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHRQIKYRNNVIECDHGKLK
+RIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPLGEMRLVSRVFEM
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13610> PF13610</a>
+<p align="justify">DDE domain<br>This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a>
+ <p align="justify">Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00011</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00126> PF00126</a>
+<p align="justify">Bacterial regulatory helix-turn-helix protein, lysR family<br></p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00013</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFTFDASLQSLLMLTFFSSIGLSSDFSRLIKGG
+KPLVLLTIAVTILIAIQNTVGMSMAVMMNESPFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVAR
+HLLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKDTFLQLPTFVWCLFVGIIIRNTLTHVFKHEV
+FEPTVDVLGSVALSLFLAMALMSLKFGQLASMAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTV
+TKAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03616> PF03616</a>
+<p align="justify">Sodium/glutamate symporter<br>TIGRFAMs, Griffiths-Jones SR </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0064> CL0064</a>
+ <p align="justify">CPA/AT transporter superfamily This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00014</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLATEGKMLSLSWWENEYAVLQWKNHVLHAKAQQEGRESIFDFYKISI
+AHITREYSFKKDKDNV
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03992> PF03992</a>
+<p align="justify">Antibiotic biosynthesis monooxygenase<br>This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0032> CL0032</a>
+ <p align="justify">Dimeric alpha/beta barrel superfamily This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel. The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00015</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHFLVEQGKEAKIALEQAGLLVLAIRTPLIRKLKQEKPGELGEIARVL
+AENNINILVQYSDHANQLILITDNDSMAASVTLPWAIK
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01842> PF01842</a>
+<p align="justify">ACT domain<br>This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme. The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine . Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585 </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0070> CL0070</a>
+ <p align="justify">These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains . The relationship between these two families was first noticed in . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00016</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRLAGKDIAELMESMMGISLNHGVHARVSTPV
+HLRKARTCYDHLAGEVAVKIYDSLCQQQWITENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKG
+WLTRHLGYREVTITEKGYAAFKTHFHI
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF12840> PF12840</a>
+<p align="justify">Helix-turn-helix domain<br>This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%></HR>
+<center><b>PROKKA_00017</b><br>
+</center>
+</td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFLRNNAKSFRCAL
+LSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQ
+GAEPAFLFGLELIICGLEKQLKCESGS
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00440> PF00440</a>
+<p align="justify">tetR; <br>Bacterial regulatory proteins, tetR family </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02909> PF02909</a>
+<p align="justify">tetR_C; <br>Tetracyclin repressor, C-terminal all-alpha domain </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0174> CL0174</a>
+ <p align="justify">TetR protein, C-terminal domain-like This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4]. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+</table>
+</div>
+</body>
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/script.js
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/script.js	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,11 @@
+function show(elementID) {
+    var ele = document.getElementById(elementID);
+    if (!ele) {
+        alert("no such element");
+        return;
+    }
+    var pages = document.getElementsByClassName('page');
+    for(var i = 0; i < pages.length; i++) {
+        pages[i].style.display = 'none';
+    }
+    ele.style.display = 'block';
diff -r 000000000000 -r 68a3648c7d91 pfam_annot/table
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_annot/table	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,51 @@
+# pfam_scan.pl,  run at Fri Jun 19 13:56:11 2015
+#
+# Copyright (c) 2009 Genome Research Ltd
+# Freely distributed under the GNU 
+# General Public License
+#
+# Authors: Jaina Mistry (jaina@ebi.ac.uk), 
+#          Rob Finn (rdf@ebi.ac.uk)
+#
+# This is free software; you can redistribute it and/or modify it under
+# the terms of the GNU General Public License as published by the Free Software
+# Foundation; either version 2 of the License, or (at your option) any later version.
+# This program is distributed in the hope that it will be useful, but WITHOUT
+# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+# FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+# details.
+#
+# You should have received a copy of the GNU General Public License along with
+# this program. If not, see <http://www.gnu.org/licenses/>. 
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+#      query sequence file: /home/inmare/galaxy/database/files/000/dataset_62.dat
+#     cpu number specified: 2
+#        searching against: /home/inmare/galaxy/tools/pfamScan/hmm/Pfam-A.hmm, with cut off --cut_ga
+#    resolve clan overlaps: on
+#     predict active sites: off
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+#
+# <seq id> <alignment start> <alignment end> <envelope start> <envelope end> <hmm acc> <hmm name> <type> <hmm start> <hmm end> <hmm length> <bit score> <E-value> <significance> <clan>
+
+PROKKA_00001      9     46      9     46 PF00376.18  MerR              Family     1    38    38     43.1   2.2e-11   1 CL0123   
+PROKKA_00001     51    113     51    113 PF09278.6   MerR-DNA-bind     Domain     1    65    65     67.9   7.2e-19   1 CL0123   
+PROKKA_00002      1    116      1    116 PF02411.10  MerT              Family     1   116   116    214.7   1.7e-64   1 No_clan  
+PROKKA_00003     25     85     25     86 PF00403.21  HMA               Domain     1    61    62     60.3   1.4e-16   1 No_clan  
+PROKKA_00004      8    121      8    123 PF03203.9   MerC              Family     1   114   116     81.1   7.4e-23   1 No_clan  
+PROKKA_00005      3     62      3     63 PF00403.21  HMA               Domain     1    61    62     37.8   1.5e-09   1 No_clan  
+PROKKA_00005    100    410     99    412 PF07992.9   Pyr_redox_2       Domain     2   199   201    140.8   4.8e-41   1 CL0063   
+PROKKA_00005    271    345    271    354 PF00070.22  Pyr_redox         Domain     1    74    80     51.6   9.3e-14   1 CL0063   
+PROKKA_00005    440    548    440    549 PF02852.17  Pyr_redox_dim     Domain     1   109   110    104.5   2.9e-30   1 No_clan  
+PROKKA_00006      4     72      4     73 PF13411.1   MerR_1            Family     1    68    69     44.0   1.3e-11   1 CL0123   
+PROKKA_00007      2     74      1     75 PF05052.7   MerE              Family     2    74    75    142.4     3e-42   1 No_clan  
+PROKKA_00008     13    218     11    219 PF00563.15  EAL               Domain     3   209   236    169.6   7.3e-50   1 No_clan  
+PROKKA_00009     26     78     26     87 PF13518.1   HTH_28            Domain     1    46    52     26.9   3.4e-06   1 CL0123   
+PROKKA_00009    173    313    172    313 PF00665.21  rve               Domain     2   120   120     85.4   2.9e-24   1 CL0219   
+PROKKA_00010     75    212     73    213 PF13610.1   DDE_Tnp_IS240     Domain     4   139   140    170.7   1.6e-50   1 CL0219   
+PROKKA_00011      3     40      3     41 PF00126.22  HTH_1             Domain     1    38    60     48.8   4.1e-13   1 CL0123   
+PROKKA_00013      2    366      1    366 PF03616.9   Glt_symporter     Family     2   368   368    544.8  6.1e-164   1 CL0064   
+PROKKA_00014      1     76      1     77 PF03992.11  ABM               Domain     1    77    78     48.0   8.8e-13   1 CL0032   
+PROKKA_00015     78     98     74    115 PF01842.20  ACT               Domain     9    29    66     20.5   0.00024   1 CL0070   
+PROKKA_00016      5     55      1     55 PF12840.2   HTH_20            Domain    11    61    61     35.6   5.6e-09   1 CL0123   
+PROKKA_00017     10     55      9     55 PF00440.18  TetR_N            Domain     2    47    47     53.5   1.3e-14   1 CL0123   
+PROKKA_00017     68    201     68    201 PF02909.12  TetR_C            Domain     1   139   139    165.1   6.5e-49   1 CL0174   
diff -r 000000000000 -r 68a3648c7d91 pfam_search/annota.Filter.pl
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/annota.Filter.pl	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,206 @@
+#!/usr/bin/perl -w
+
+use strict;
+my $d_file="/home/inmare/galaxy/tools/pfam_search/pfamA.txt";
+open(IN,$d_file);
+my %decode=();
+my %clan_decode;
+my $id="";
+my %c=();
+
+
+my ($prot_file,$pfam_file,$prefix,@search_T)=@ARGV;
+my $searchP="";
+while(<IN>)
+{
+        if ($_=~/^\d/)
+        {
+                my @vl=(split(/\t+/));
+		$decode{$vl[1]}="$vl[3]<br>";#$vl[8] $vl[9]";
+                my $cc=0;
+		my %repeated=();
+		foreach my $v (@vl)
+                {
+			$v=~s/\[\d+\]/ /g;
+			$cc++;
+			last if $v=~/hmmbuild/;
+                        last if $cc>10;
+                        next if $v=~/anon/;
+                        next if $v=~/Bates/;
+                        next if $v=~/Cogis/;
+                        next if $v=~/Bateman/;
+                        next if $v=~/Sonnhammer/;
+                        next if $v=~/Finn/;
+			next if $v=~/Studholme/;
+			next if $v eq $vl[3];
+			next if $v=~/Kerrison/;
+                        next if $repeated{$v};
+                        #next if length($v)>=30 && $cc<=10;
+			$decode{$vl[1]}.="$v " if length($v)>=20 && $cc<=10;
+                	$repeated{$v}++;
+		}
+        }
+}
+close(IN);
+
+my $clan_file="/home/inmare/galaxy/tools/pfam_search/clans.txt";
+open(IN,$clan_file);
+while(<IN>)
+{
+        my @vl=(split(/\t/));
+       	#$clan_decode{$vl[1]}="$vl[3]";
+	my $cc=0;
+        foreach my $v (@vl)
+	{
+		$cc++;
+		$v=~s/\[\d+\]/ /g;
+		$clan_decode{$vl[1]}.="$v " if length($v) >=30 && $cc<=10;
+	}	
+
+}
+close(IN);
+open(IN,"$prot_file");
+while(<IN>)
+{
+        if ($_=~/^>(.*)/)
+        {
+                $id=$1;
+		$id=(split(/\s+/,$id))[0];
+        }else{
+		chomp;
+                $c{$id}.=$_;
+        }
+}
+close(IN);
+
+foreach my $s (@search_T)
+{
+	$searchP.="$s ";
+}
+
+open(OUT,">$prefix");
+print OUT "<html>\n<head></head>\n<body>\n";
+my $color="\"#czb9dz\"";
+my %printed;
+open(IN,$pfam_file);
+print OUT "Proteins with PFAM domains matching the keywords:\n<br><br>\n";
+print OUT "<div>\n<table cellpadding=\"0\" width=650>\n";
+my $ntokens=0;
+while(<IN>)
+{
+        next if $_=~/^\#/;
+        my ($name,$domain,$clan)=(split(/\s+/))[0,5,-1];
+	next unless $name;
+	next unless $domain;
+	$domain=~s/\.\d+//;
+	my $sd=$decode{$domain} ? $decode{$domain} : "MagnottaPantaleo§§";
+	my $sc=$clan_decode{$clan} ? $clan_decode{$clan} : "SciarrattaCalogero@@";
+	my $continue=match($searchP,$sd,$sc);
+	#print "$name $domain $clan $sd $sc\n";
+	next unless $continue;
+        unless ($printed{$name})
+	{
+		my $seq=$c{$name};
+		
+		$seq=~s/\*//g;
+		$seq=form($seq,90);
+		print OUT "<td>\n";
+		print OUT "<HR SIZE=3 WIDTH=80%>\n";
+		print OUT "<center><b>$name</b><br>\n</center>\n";
+		print OUT "</td\n<tr></tr>\n";
+                print OUT "<td bgcolor=$color>\n";
+		print OUT "<pre> \n$seq\n </pre>\n";
+		print OUT "</td>\n<tr></tr>\n<td></td>\n<tr></tr>\n";
+		$ntokens=2;
+	}
+	my $hd=uc $domain;
+	#<a href="http://www.canoro.altervista.org/" class="nav" target="_blank">www.canoro.altervista.org</a>
+	if ($decode{$domain})
+	{
+		my $ddes=$decode{$domain};
+		if ($ntokens % 2==0)
+                {
+                        print OUT "<td>\n";
+                }else{
+                        print OUT "<td bgcolor=$color>\n";
+                }
+	
+		print OUT "<p align=\"left\">\n";
+        	print OUT "<a href=http://pfam.xfam.org/family/$hd> $domain</a>\n<p align=\"justify\">$ddes</p>\n\n";
+		print OUT "</p>\n</td>\n<tr></tr>\n<td></td>\n<tr></tr>\n";
+		$ntokens++;
+	}
+        if ($clan_decode{$clan})
+        {
+                my $clanD=$clan_decode{$clan};
+		my $ddes=$decode{$domain};
+                if ($ntokens % 2==0)
+                {
+                        print OUT "<td>\n";
+                }else{
+                        print OUT "<td bgcolor=$color>\n";
+                }
+
+                print OUT "<p align=\"left\">\n";
+		print OUT "<a href=http://pfam.xfam.org/clan/$clan> $clan</a>\n <p align=\"justify\">$clanD</p>\n\n";
+		print OUT "</p>\n</td>\n<tr></tr>\n<td></td>\n<tr></tr>\n";
+		$ntokens++;
+        }
+        $printed{$name}=1;
+}
+
+#print OUT "<br><br>Proteins without PFAM domains:\n<br>\n";
+#foreach my $seq (keys %c)
+#{
+#        next if $printed{$seq};
+#        print OUT "<>$seq</pre>\n\n<br><br><left>\n$c{$seq}</left><br>\n";
+#	print OUT "<HR SIZE=3 WIDTH=80%>\n";
+#}
+print OUT "</table>\n</div>\n</body>\n</html>\n";
+close(OUT);
+
+sub form
+{
+	my $string=$_[0];
+	my $len=$_[1];
+	my $outS="";
+	my @vl=split('',$string);
+	for (my $i=1;$i<=$#vl;$i++)
+	{
+		if ($i % $len==0 && $i>0)
+		{
+			$outS.="$vl[$i-1]\n";
+		}else{
+			$outS.=$vl[$i-1];
+		} 
+	}
+	$outS.="\n";
+	$outS=~s/ //g;
+	return $outS;
+}
+
+sub match
+{
+	my $terms=$_[0];
+	my $d1=$_[1];
+	my $d2=$_[2];
+	$terms=~s/AND/ /g;
+	my @t1s=(split(/OR/,$terms));
+	my $print_out=0;
+	foreach my $t (@t1s)
+	{
+		#print "$t\n";
+		last if $print_out==1; #OR non serve se 1 è verificata;
+		#permute
+		my @vl=(split(/\s+/,$t));
+		my $nm1=0;
+		my $nm2=0;
+		foreach my $v (@vl)
+		{
+			$nm1++ if ($d1=~/$v/i);
+			$nm2++ if ($d1=~/$v/i);		
+		}
+		$print_out=1 if ($nm1==($#vl+1)) || ($nm2==($#vl+1));
+	}
+	return $print_out;
+}
diff -r 000000000000 -r 68a3648c7d91 pfam_search/clans.txt
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/clans.txt	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,515 @@
+1	CL0001	EGF	\N	EGF superfamily	Finn RD, Bateman A	anon	Members of this clan all belong to the EGF superfamily.  This particular superfamily is characterised as having least 6 cysteines residues.\	\	\	\	   These cysteine form disulphide bonds, in the order 1-3, 2-4, 5-6, which are essential for the stability of  the EGF fold.    These disulphide bonds are stacked in a ladder-like arrangement.  The Laminin EGF family is distinguished by having an an additional disulphide bond.  The function of the domains within  this family remains unclear, but they are though to largely  perform a structural role.  More often than not, there domains are arranged a tandem repeats in extracellular proteins.	2008-09-03 15:50:29	2004-03-17 16:02:08	26	325	6259	696	88541	1
+3	CL0003	SAM	\N	Sterile Alpha Motif (SAM) domain	Finn RD	anon	SAM domains are found in a diverse set of proteins, which include  scaffolding proteins, transcription regulators, translational  regulators tyrosine kinases and serine/threonine kinases [1-3].   SAM domains are found in all eukaryotes and some bacteria [3] .   Structures of SAM domains reveal a common five helical structure.  The SAM domain is involved in a variety of functions. The most widespread function is in domain-domain interactions.   The SAM domain performs domain-domain interactions using multifarious  arrangements of the SAM domain.  More recently, the SAM domain within  the Smaug protein has been demonstrated to bind to the Nanos 3' UTR translation control element (Rfam:RF00161) [3]. This clan currently only represents the diverse SAM domain family and does not contain the more divergent SAM/Pointed family (Pfam:PF02198).	2008-09-03 15:50:29	2004-03-17 16:21:50	20	126	742	467	11010	1
+4	CL0004	Concanavalin	\N	Concanavalin-like lectin/glucanase superfamily	Bateman A	anon	This superfamily includes a diverse range of carbohydrate binding domains and glycosyl hydrolase enzymes that share a common structure.	2008-09-03 15:50:29	2004-03-17 16:44:11	19	1631	2750	3131	34755	1
+5	CL0005	Kazal	\N	Kazal like domain	Finn RD	anon	Kazal domains are found in both serine protease inhibitors and extracellular regions of agrins. The structure of the Kazal domain is a small alpha/beta fold. Typically the Kazal domain consists of 2 short-helices and a  3-stranded anti-parallel sheet.  The fold is contains several disulphide bonds. 	2008-09-03 15:50:29	2004-03-17 17:00:11	26	106	337	450	6552	1
+6	CL0006	C1	\N	Protein kinase C, C1 domain	Finn RD	anon	The members of this clan are all variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content.  The C1 domain is the N-terminal region of conservation found in protein kinase C domains.  This domain is involved in binding many ligands, which include diacylglycerol, phorbol  esters and zinc [1].	2008-09-03 15:50:29	2004-03-17 17:47:56	19	30	728	396	10495	1
+7	CL0007	KH	\N	K-Homology (KH) domain Superfamily	Finn RD	anon	The KH domain is thought to be the second most prevalent RNA  binding motif in proteins.  The motif is characterised by a  conserved GXXXGXXG in the middle of the domain.  Structures of KH reveal that the KH domain is arranged as either a  beta-alpha-alpha-beta-beta (mini-KH domain) or  beta-alpha-alpha-beta-beta-alpha (maxi-KH domain).  The secondary elements are separated by at least four loop segments. The second loop is located between beta-1 and al  The KH domain can be found either as single or multiple copies.  The KH domain usually binds RNA as a multimer.	2008-09-03 15:50:29	2004-03-17 17:58:30	17	312	491	5344	38636	1
+9	CL0009	ENTH_VHS	\N	ENTH/ANTH/VHS superfamily	Bateman A, McMahon H	anon	This clan includes the related ENTH and ANTH domains as well as the VHS domain. The ENTH domain is approximately 150 residues in length and is a solenoid of alpha-helices. The various ENTH domains have various lipid specificities but the key feature that distinguishes it functionally from ANTH domains is its ability to bend membranes. It does  this by folding an additional N-terminal helix on lipid binding. The ANTH domain is approximately 300 residues in length and is a PtdIns(4,5)P2 binding domain. It has no membrane bending properties. The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking [5].	2008-09-03 15:50:29	2004-03-18 10:53:33	19	75	85	345	4028	1
+10	CL0010	SH3	\N	Src homology-3 domain	Finn RD	anon	Src homology-3 (SH3) domains are comprised of about 60 amino acids, performing either an assembly or regulatory role.\	       For example, SH3 domains in the Grb2 adaptor protein  are essential for protein-protein interactions and\	\	      signal transduction in the p21 Ras-dependent growth factor signaling pathway.  Alternatively, SH3 performs a regulatory role in the Src family of tyrosine kinases. SH3 domains bind a variety of peptide ligands, many of which  contain a PxxP motif.  This PxxP motif is flanked by different specificity elements [1].   Structures of SH3 domains, both free and ligand complexed, have provided insights into the mechanism of ligand recognition. The SH3 fold consists of two anti-parallel beta sheets that lie  at right angles to each other.  Within the fold, there are two variable loops, referred to as RT and n-Src loops.  When SH3 binds to its ligand, the proline rich ligand adopts a PPII helix conformation, with the PPII helix structure recognised by a pair of grooves on the surface of the SH3 domain that  bind turns of the helix.  The SH3 grooves  are formed by a series of nearly parallel, well-conserved aromatic residues [1].	2008-09-03 15:50:29	2004-03-18 11:12:55	20	564	2030	4044	40209	1
+11	CL0011	Ig	\N	Immunoglobulin superfamily	Bateman A, Finn RD	anon	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases.  Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The superfamily can be divided into discrete structural sets, by the presence or absence of beta-strands in the structure and the  length of the domains [1]. Proteins containing domains of the C1 and V-sets are mostly molecules of the vertebrate immune system. Proteins of the C2-set are mainly lymphocyte antigens, this differs from the composition of the C2-set as originally proposed [1]. The I-set is intermediate in structure between the C1 and V-sets and is found widely in cell surface proteins as well as intracellular muscle proteins.	2008-09-03 15:50:29	2004-03-18 16:23:40	25	3370	4292	3474	136715	1
+12	CL0012	Histone	\N	Histone superfamily	Bateman A	anon	Members of this clan all possess a histone fold. Generally proteins in this clan are DNA binding.	2008-09-03 15:50:29	2004-04-19 14:28:04	17	742	154	9904	23976	1
+13	CL0013	Beta-lactamase	\N	Serine beta-lactamase-like superfamily	Finn RD, Bateman A	anon	This superfamily contains proteins that have a beta-lactamase fold.  This includes beta-lactamases as well as Dala-Dala carboxypeptidases and glutaminases.	2008-09-03 15:50:29	2004-04-19 15:42:28	17	961	303	5474	58501	1
+14	CL0014	Glutaminase_I	\N	Class-I Glutamine amidotransferase superfamily	Bateman A	anon	Most members of this clan are glutaminase enzymes. This superfamily is shown to be related in [1]. The clan also contains the DJ-1/PfpI family that includes the peptidase PfpI that has a catalytic Cys-His-Glu triad that differs from the class I GAT Cys-His-Glu triad.	2008-09-03 15:50:29	2004-04-28 09:27:01	21	334	418	7216	67224	1
+15	CL0015	MFS	\N	Major Facilitator Superfamily	Bateman A	anon	The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].	2008-09-03 15:50:29	2004-04-30 16:48:27	19	22	846	6356	249360	1
+16	CL0016	PKinase	\N	Protein kinase superfamily	Studholme DJ	anon	This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.	2008-09-03 15:50:29	2004-06-11 14:28:37	21	3279	6514	9586	173964	1
+18	CL0018	bZIP	\N	bZIP-like leucine zipper	Studholme DJ	anon	This family of eukaryotic transcription factors contain a basic region adjacent to a leucine zipper.	2008-09-03 15:50:29	2004-06-16 18:30:26	14	321	111	611	8901	1
+20	CL0020	TPR		Tetratrico peptide repeat superfamily	Studholme DJ	anon	Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.	2008-09-03 15:50:29	2004-06-21 18:12:39	24	947	20914	6771	404043	1
+21	CL0021	OB	\N	OB fold	Studholme DJ, Bateman A	anon	The OB (oligonucleotide/oligosaccharide binding) was defined by Murzin [1]. The common part of the OB-fold, has a five-stranded beta-sheet coiled to form a closed beta-barrel. This barrel is capped by an alpha-helix located between the third and fourth strands [1].	2008-09-03 15:50:29	2004-06-22 18:31:10	17	1592	988	7656	210543	1
+22	CL0022	LRR		Leucine Rich Repeat	Studholme DJ	anon	Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.  This Pfam entry contains Leucine Rich Repeats not recognised by the Pfam:PF00560 model.	2008-09-03 15:50:29	2004-06-23 16:13:12	31	250	9511	3145	175606	1
+23	CL0023	P-loop_NTPase	AAA;	P-loop containing nucleoside triphosphate hydrolase superfamily	Studholme DJ	anon	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	2008-09-03 15:50:29	2004-06-23 17:05:20	33	5523	12211	50680	1511292	1
+25	CL0025	His_Kinase_A		His Kinase A (phospho-acceptor) domain	Studholme DJ	anon	This is the dimerisation and phospho-acceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea.  It comprises one of the fundamental units of the two-component signal transduction system [2-7].	2008-09-03 15:50:29	2004-06-29 14:19:46	13	497	5781	7648	242300	1
+26	CL0026	CU_oxidase	\N	Multicopper oxidase-like domain	Studholme DJ, Finn RD	anon	Many of the proteins in this family contain multiple similar  copies of this plastocyanin-like domain.	2008-09-03 15:50:29	2004-06-29 16:37:59	19	1015	245	19953	63536	1
+27	CL0027	RdRP	\N	RNA dependent RNA polymerase	Bateman A	anon	This clan represents the replicative  RNA dependent RNA polymerase. from a variety of RNA viruses [1].	2008-09-03 15:50:29	2004-08-26 14:33:23	14	852	1801	12549	220781	1
+28	CL0028	AB_hydrolase		Alpha/Beta hydrolase fold	Bateman A	anon	This catalytic domain is found in a very wide range of enzymes.	2008-09-03 15:50:29	2004-08-29 17:32:06	21	1989	2396	7428	180167	1
+29	CL0029	Cupin		Cupin fold	Bateman A	anon	This clan represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). The cupin fold is found in a wide variety of enzymes, but notably contains the non-enzymatic seed storage proteins also.	2008-09-03 15:50:29	2004-09-06 15:03:53	19	945	1162	6529	112082	1
+30	CL0030	Ion_channel	\N	Ion channel (VIC) superfamily	Bateman A	anon	This superfamily contains a diverse range of ion channels that share a pair of transmembrane helices in common. This clan is classified as the VIC (Voltage-gated Ion Channel) superfamily in TCDB.	2008-09-03 15:50:29	2004-09-08 16:21:26	15	718	809	5250	44250	1
+31	CL0031	Phosphatase	\N	Phosphatase superfamily	Bateman A	anon	This family includes tyrosine and dual specificity phosphatase enzymes.	2008-09-03 15:50:29	2004-10-26 13:53:48	12	480	558	2966	20482	1
+32	CL0032	Dim_A_B_barrel	\N	Dimeric alpha/beta barrel superfamily	Bateman A	anon	This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel.  The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases.	2008-09-03 15:50:29	2004-10-26 16:31:17	14	510	186	4601	39476	1
+33	CL0033	POZ	\N	POZ domain superfamily	Bateman A	anon	The POZ domain is found in a variety of transcription factors.  POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.	2008-09-03 15:50:29	2004-10-27 13:52:11	13	223	1167	1178	26677	1
+34	CL0034	Amidohydrolase	\N	Amidohydrolase superfamily	Bateman A	anon	This family includes a large family of metal dependent amidohydrolase enzymes [1].	2008-09-03 15:50:29	2004-10-27 17:19:50	14	704	479	5687	79783	1
+35	CL0035	Peptidase_MH	\N	Peptidase clan MH/MC/MF	Bateman A	anon	This clan contains peptidases belonging to MEROPS clan MH, MC and MF.  We also include Nicastrin that is part of the gamma secretase complex and not known to be a peptidase.	2008-09-03 15:50:29	2004-10-28 13:48:22	15	680	539	5405	63766	1
+36	CL0036	TIM_barrel		Common phosphate binding-site TIM barrel superfamily	Bateman A	anon	This large superfamily of TIM barrel enzymes all contain a common phosphate binding site. The phosphate is found in a variety of cofactors and ligands such as FMN [1,2].	2008-09-03 15:50:29	2004-10-28 15:12:01	23	3964	973	10099	253453	1
+37	CL0037	Lysozyme	\N	Lysozyme-like superfamily	Bateman A	anon	Barley chitinase, bacterial chitosanase, and lysozymes from phage and animals all hydrolyse related polysaccharides. The proteins little amino-acid similarity, but have a structurally invariant core consisting of two helices and a three-stranded beta-sheet which form the substrate-binding and catalytic cleft [1].	2008-09-03 15:50:29	2004-10-28 15:30:21	13	1502	527	5612	33680	1
+39	CL0039	HUP	PP-loop; PP-ATPase;	HUP - HIGH-signature proteins, UspA, and PP-ATPase.	Bateman A, Anantharaman V	anon	The HUP class contains the HIGH-signature proteins, UspA superfamily and the PP-ATPase superfamily [1]. The HIGH superfamily has the HIGH Nucleotidyl transferases and the class I tRNA synthetases both of  which have the HIGH and the KMSKS motif [1],[2]. The PP-loop ATPase  named after the ATP PyroPhosphatase domain, was initially  identified as a conserved amino acid sequence motif in four distinct groups of enzymes that catalyse the hydrolysis of the alpha-beta phosphate bond of ATP, namely GMP synthetases, argininosuccinate synthetases, asparagine synthetases, and ATP sulfurylases [3]. The USPA superfamily  contains USPA, ETFP and Photolyases [1]	2008-09-03 15:50:29	2004-10-29 14:36:02	11	1108	838	6582	177746	1
+40	CL0040	tRNA_synt_II	\N	Class II aminoacyl-tRNA and Biotin synthetases	Finn RD	anon	Aminoacyl-tRNA synthetases are key components of the protein translation  machinery that catalyse two basic reactions. First, the activation of  amino acids via the formation of aminoacyl adenylates and second, linking the activated amino acid to the cognate tRNAs. The aminoacyl-tRNA synthetases generate AMP as the second end product of this reaction, which differentiates them from the majority of ATP-dependent enzymes that produce ADP. In addition, there is a specific  aminoacyl-tRNA synthetases for each of the 20 amino acids and there are  two structurally distinct classes of aminoacyl-tRNA synthetases, each\	\	  encompassing 10 different specificities. The two classes have alternative modes of aminoacylation: class I aminoacylate the 2'OH of the cognate tRNA; class II aminoacylate 3'OH (with the exception of PheRS). Each class contain a conserved core domain  that is involved in ATP binding and hydrolysis and combines with  additional domains that determine the specificity of interactions with\	       the cognate amino acid and tRNA.  The class II core domain consist of a mixed-beta sheet, similar to that found in the biotin synthetases, hence why this family has also been included in  this clan.  The core domain contains three modestly conserved motifs  that are responsible for ATP binding.  The class II aminoacyl-tRNA  synthetases can contain additional nested domains, found inserted in the loops of the core domain [1] (and  reference therein).	2008-09-03 15:50:29	2004-11-08 11:24:57	16	514	340	5927	72316	1
+41	CL0041	Death	\N	Death Domain Superfamily	Finn RD	anon	The death domain superfamily is composed of three families: the death domain (DD); the death effector domain (DED) and the caspase recruitment domain (CARD).  All of the members perform a pivotal role in signalling events that regulate apoptosis.   Protein-protein interactions are mediated by self-self associations, in which CARD-CARD, DD-DD and  DED-DED contacts are formed exclusively The three families possess remarkably similar structures, each comprising an antiparallel six helical bundle in the Greek Key topology.  Structurally, the DD and CARD families are the most dissimilar.  The former is comprised of two perpendicular three-helix bundles, whereas the latter CARD domain contains six helices that are almost parallel with each other.  Interestingly, the interactions in CARD or DD containing heterodimers are quite different [1]. 	2008-09-03 15:50:29	2004-11-11 10:28:31	12	135	742	249	6544	1
+42	CL0042	Flavoprotein	\N	Flavoprotein	Finn RD	anon	Members of this clan are FMN or FAD-binding redox proteins.  Flavoproteins act in various electron-transport systems as  functional analogues of ferredoxin.  They are characterised by an open twisted alpha/beta structure consisting of five parallel  beta-sheets connected by alpha-helices which surround the sheet.	2008-09-03 15:50:29	2004-11-12 15:13:12	11	497	221	5019	35666	1
+43	CL0043	Chelatase	\N	Chelatase Superfamily	Finn RD	anon	Metallated tetrapyrroles are used as prosthetic groups in  proteins involved in biologically important processes such as  photosynthesis, oxygen transport, drug metabolism and  nitric oxide synthesis. In living organisms, metallation is catalysed  by a group of enzymes called chelatases. This clan contains  ferrochelatase (heme) and cobalt chelatase [1]. 	2008-09-03 15:50:29	2004-11-12 16:49:49	11	77	45	4178	7625	1
+44	CL0044	Ferritin		Ferritin-like Superfamily	Finn RD	anon	The members of this clan all share a distinctive four helical bundle. The four helices are arranged antiparallel with a left-handed twist. This helical bundle is distinguished from others by the long connection between the second and third helices.  Some of the members contain a Fe or Mn dimer at the centre of the helical bundle.  The ferritin fold was first described by Murzin AG and Chothia C, Cur Opin Struc Biol 1992, 2:895-903.	2008-09-03 15:50:29	2004-11-12 17:32:27	13	2058	121	6054	34310	1
+45	CL0045	Rubredoxin	\N	Rubredoxin-like	Finn RD	anon	The Rubredoxin clan is comprised of three families:Rubredoxin, COX5B and desulforedoxin.Rubredoxin domains are small domains  (5-6 kDa) and bind one iron atom tetrahedrally bound by four cysteine  residues.Similar, desulforedoxin domains are small (4 kDa), but  usually form homodimers.  Each monomer binds one iron atom, but in  a distorted tetrahedral arrangement.  COX5B domains are membrane-anchored  rubredoxin-like domains. The domain in the Rubredoxin clan are usually comprised of 2 alpha helixes and 2-3 beta strands.	2008-09-03 15:50:29	2004-11-15 11:37:59	11	172	52	2672	4680	1
+46	CL0046	Thiolase	\N	Thiolase-like Superfamily	Finn RD	anon	Thiolases are ubiquitous and form a large superfamily. Thiolases can function either degradatively, in the beta-oxidation  pathway of fatty acids, or biosynthetically. Biosynthetic thiolases  catalyse the formation of acetoacetyl-CoA from two molecules of  acetyl-CoA . This is one of the fundamental categories of carbon  skeletal assembly patterns in biological systems and is the first step  in a wide range of biosynthetic pathways [1].  Thiolase are usually dimeric or tetrameric enzymes.  Within each monomer there are two similar domains related by pseudo dyad.  The N-terminal of these two domains contains a large insertion of about 100 amino  acids.	2008-09-03 15:50:29	2004-11-15 12:47:24	15	575	1810	7516	102610	1
+47	CL0047	CuAO_N2_N3	\N	Copper amine oxidase, domains 1 and 2	Finn RD	anon	Copper amine oxidase (CuAO) are comprised of three of four domains. In the case of the four domain CuAO, the N-terminal domain (termed N1, and is not present in the three domain CuAO) and the C-terminal catalytic domain sandwich two repeated domains (termed N2 and N3).  The function of these two homologous domains is uncertain.  N2 and N3 both have a cystatin-like fold [1].	2008-09-03 15:50:29	2004-11-15 13:04:24	11	186	31	504	1887	1
+48	CL0048	LolA_LolB	\N	Lipoprotein localisation factors LolA/B	Finn RD	anon	Gram-negative bacteria lipoproteins are anchored to the periplasmic  surface of the inner or outer membrane depending on the sorting signal, which is the residue at position 2 of the polypeptide. Five Lol proteins  are involved in the sorting and membrane localisation of lipoprotein. An ATP-binding cassette (ABC) transporter, LolCDE, releases outer  membrane-specific lipoproteins from the inner membrane, causing the  formation of a complex between the released lipoproteins and the  periplasmic molecular chaperone LolA. When this complex interacts with  outer membrane receptor LolB, the lipoproteins are transferred from LolA  to LolB and then localised to the outer membrane. The structures of LolA  and LolB are remarkably similar to each other. Both have a hydrophobic  cavity consisting of an unclosed beta-barrel and an alpha-helical  lid [1,2].	2008-09-03 15:50:29	2004-11-15 13:13:26	11	10	5	2158	3976	1
+49	CL0049	Tudor	\N	Tudor domain 'Royal family'	Finn RD, Bateman A	anon	This clan covers the Tudor domain 'royal family' [1]. This includes chromo, MBT, PWWP and tudor domains.  The chromo domain is a comprised of approximately 50 amino acid residues. There are usually one to three Chromo domains found in a single protein. In some chromo domain containing proteins, a second related chromo domain has been found and is referred to as the Chromo-shadow domain.  The structure of the Chromo and Chromo-shadow domains reveal an OB-fold, a fold found in a variety of prokaryotic and eukaryotic nucleic acid binding proteins.\	More specifically,the chromo-domain structure reveals a three beta strands that are packed against an alpha helix. Interestingly, a similar structure is found in the archaeal chromatin proteins (7kDa DNA-binding domain).  These are sequence neutral DNA binding proteins.\	The DNA binding in these archaeal proteins is mediated through the triple stranded beta sheet. These archaeal domains are though to represent an ancestral chromo domain. Homologs of the chromo domain have been found in fission yeast, ciliated protozoa and all animal species, but appear to be absent in eubacteria, budding yeast and plants [2]. The precise function of the chromo domain is unclear, but the chromo domain is thought to act as a targeting module for chromosomal proteins, although the chromosomal contexts and functional contexts being targeted vary.  In all cases studies, the chromo domains are found in proteins that are involved in transcription regulation, positive and negative [2].	2008-09-03 15:50:29	2004-11-16 16:02:09	14	325	682	504	17304	1
+50	CL0050	HotDog	\N	HotDog superfamily	Bateman A	anon	The HotDog fold was first observed in the structure of Escherichia coli beta-hydroxydecanoyl thiol ester dehydratase (FabA), where Leesong et al. noticed that each subunit of this dimeric enzyme contained a mixed alpha + beta 'hot dog' fold. They described the seven-stranded antiparallel beta-sheet as the 'bun', which wraps around a five-turn alpha-helical 'sausage', This superfamily contains a diverse range of enzymes. Membership includes numerous prokaryotic, archaeal and eukaryotic proteins involved in several related, but distinct, catalytic activities, from metabolic roles such as thioester hydrolysis in fatty acid metabolism, to degradation of phenylacetic acid and the environmental pollutant 4-chlorobenzoate. The superfamily also includes FapR, a non-catalytic bacterial homologue that is involved in transcriptional regulation of fatty acid biosynthesis [1].	2008-09-03 15:50:29	2004-11-19 13:30:09	11	673	1411	5349	52323	1
+51	CL0051	NTF2		NTF2-like superfamily	Bateman A	anon	This superfamily contains a variety of enzymes such as Scytalone dehydratase, Delta-5-3-ketosteroid isomerase, Limonene-1,2-epoxide hydrolase among others. The family also includes presumed non-enzymatic homologues such as NTF2.	2008-09-03 15:50:29	2004-11-19 15:35:00	13	603	332	4350	23892	1
+52	CL0052	NTN	\N	NTN hydrolase superfamily	Bateman A	anon	In the N-terminal nucleophile aminohydrolases (Ntn hydrolases) the N-terminal residue provides two catalytic groups, nucleophile and proton donor. These enzymes use the side chain of the amino-terminal residue, incorporated in a beta-sheet, as the nucleophile in the catalytic attack at the carbonyl carbon. The nucleophile is cysteine in GAT, serine in penicillin acylase, and threonine in the proteasome. All the enzymes share an unusual fold in which the nucleophile and other catalytic groups occupy equivalent sites. This fold provides both the capacity for nucleophilic attack and the possibility of autocatalytic processing [1].	2008-09-03 15:50:29	2004-11-19 17:25:18	17	2263	255	5468	47927	1
+53	CL0053	4H_Cytokine		4-helical cytokine superfamily	Bateman A	anon	Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.	2008-09-03 15:50:29	2004-11-21 12:08:45	14	272	33	865	5160	1
+54	CL0054	Knottin_1	\N	Scorpion toxin-like knottin superfamily	Bateman A	anon	This clan includes a number of toxin families that share the knottin structure. These families come from scorpions, plants and arthropods.	2008-09-03 15:50:29	2004-11-22 17:39:28	12	164	12	369	2025	1
+55	CL0055	Viral_ssRNA_CP	\N	Positive stranded ssRNA viruses coat protein	Finn RD	anon	The clan contains a set of viral coat protein families and peptidase A6. The only known peptidase  activity is an autolytic cleavage releasing a 44-residue  C-terminal fragment. The reaction is very slow and only occurs  within the assembled virion. There is debate whether this is actually a true peptidase. The virion with these coat or capsid\	proteins are icosahedral viruses containing sixty triangular  coat protein units, each unit consisting of three proteins. The coat  protein consists of two subdomains, an eight-stranded beta-barrel on  the surface and a three-helix bundle on the inner face.	2008-09-03 15:50:29	2004-11-24 13:16:32	12	790	144	9475	53300	1
+56	CL0056	C_Lectin	\N	C-type lectin-like superfamily	Bateman A	anon	This clan contains domains that have a C-type lectin fold.  Many of these are known or expected to  mediate interactions with sugars.	2008-09-03 15:50:29	2004-11-24 13:34:58	11	581	825	748	15749	1
+57	CL0057	Met_repress		MetJ/Arc repressor superfamily	Bateman A	anon	This superfamily contains the MetJ and Arc repressors that feature a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA [1].	2008-09-03 15:50:29	2004-11-24 15:10:49	13	185	88	3932	18127	1
+58	CL0058	Glyco_hydro_tim		Tim barrel glycosyl hydrolase superfamily	Bateman A	anon	This large superfamily contains a range of glycosyl hydrolase enzymes that possess a TIM barrel fold. This CLAN merges clans GH-A, GH-D, GH-H and GH-K from CAZy.	2008-09-03 15:50:29	2004-11-25 11:37:58	15	2459	2481	7032	114169	1
+59	CL0059	6_Hairpin		Six-hairpin glycosidase superfamily	Bateman A	anon	This Clan includes CAZy clans GH-L, GH-M and GH-G. The members of this clan share a common structure composed of 6 helical hairpins. Most members of this superfamily are glycosyl hydrolase enzymes.	2008-09-03 15:50:29	2004-11-26 15:47:32	14	530	867	4822	41246	1
+60	CL0060	DNA_clamp	\N	DNA clamp superfamily	Bateman A	anon	Sliding DNA clamps are ring-shaped proteins that allow DNA polymerase to achieve high processivity during chromosome replication by tethering the polymerase catalytic subunit to DNA. All of the structures share a 12-fold symmetry around the ring consisting of a simple structural repeat, though there is structural divergence in some of the repeats. Bacterial beta-clamps contain six repeats per subunit with two subunits per ring while the eukaryotic and bacteriophage clamps contain four repeats per subunit with three subunits per ring. Pairs of these repeats form a domain, which has been termed the 'processivity fold'; thus the ring of the sliding clamp contains six domains and therefore is often described as having 6-fold symmetry. A structural representative of a fourth family of processivity fold proteins, namely the herpes simplex virus UL42 protein, is also available. UL42 does not form a ring-shaped clamp, however, but rather functions as a monomer and interacts with DNA quite differently than do sliding clamps; it has been suggested that UL42 resembles a primitive ancestor of sliding clamps [2].	2008-09-03 15:50:29	2004-11-26 17:13:41	11	241	64	5243	18116	1
+61	CL0061	PLP_aminotran	\N	PLP dependent aminotransferase superfamily	Bateman A	anon	This superfamily contains a variety of PLP-dependent enzymes.	2008-09-03 15:50:29	2004-11-29 11:27:35	12	1560	574	7712	152775	1
+62	CL0062	APC		APC superfamily	Bateman A	anon	This large superfamily contains a variety of transporters including amino acid permeases that according to TCDB belong to the APC (Amino acid-Polyamine-organoCation) superfamily.	2008-09-03 15:50:29	2004-11-29 18:13:15	12	36	417	5587	126928	1
+63	CL0063	NADP_Rossmann		FAD/NAD(P)-binding Rossmann fold Superfamily	Finn RD	anon	A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site [1].  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD.	2008-09-03 15:50:29	2004-11-30 13:45:28	24	8681	8330	18998	984446	1
+64	CL0064	CPA_AT	\N	CPA/AT transporter superfamily	Bateman A	anon	This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB [1].	2008-09-03 15:50:29	2004-12-02 10:12:55	11	10	163	5252	48799	1
+65	CL0065	Cyclin	\N	Cyclin-like superfamily	Bateman A	anon	This Clan contains cyclins, Transcription factor IIB (TFIIB), and the Retinoblastoma tumour suppressor proteins. These were predicted to be related by sequence [1].	2008-09-03 15:50:29	2004-12-02 13:15:02	14	236	144	804	14080	1
+66	CL0066	Trefoil	\N	Beta-trefoil superfamily	Bateman A	anon	This family corresponds to a large set of related beta-trefoil proteins [1].  The beta-trefoil is formed by six two-stranded hairpins [2]. Three of these form a barrel structure and the other three are in a triangular array that caps the barrel. The arrangement of the secondary structures gives the molecules a pseudo 3-fold axis.	2008-09-03 15:50:29	2004-12-06 15:34:20	13	659	720	1705	12929	1
+67	CL0067	SIS	\N	SIS domain fold	Bateman A	anon	This catalytic domain catalyses isomerisation reactions of a variety of sugars [1].	2008-09-03 15:50:29	2004-12-06 16:11:44	12	275	84	6149	42474	1
+68	CL0068	RIIa	\N	RIIa-like fold	Bateman A	anon	This clan includes both the RIIa dimerisation motif as well as the Dpy-30-like motif [1].	2008-09-03 15:50:29	2004-12-07 15:58:47	11	37	67	303	1405	1
+69	CL0069	GFP	\N	GFP-like superfamily	Bateman A	anon	This superfamily has an unusual fold of an 11 stranded beta barrel enclosing an alpha-helix. This superfamily includes green fluorescent protein as well as a domain from nidogen.	2008-09-03 15:50:29	2004-12-08 17:25:21	11	623	171	194	602	1
+70	CL0070	ACT	\N	ACT-like domain	Bateman A	anon	These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains [1]. The relationship between these two families was first noticed in [2].	2008-09-03 15:50:29	2004-12-08 17:26:00	12	241	221	4906	47783	1
+71	CL0071	His_phosphatase	PGM;	Histidine phosphatase superfamily	Finn RD, Rigden DJ	anon	The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue.\	Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches [1].	2008-09-03 15:50:29	2004-12-09 14:54:21	11	292	168	4773	26470	1
+72	CL0072	Ubiquitin	\N	Ubiquitin superfamily	Bateman A	anon	This family includes proteins that share the ubiquitin fold. It currently unites four SCOP superfamilies.	2008-09-03 15:50:29	2004-12-09 18:04:44	19	1053	1522	6169	107825	1
+73	CL0073	P53-like	\N	Beta-sandwich DNA-binding domain	Bateman A	anon	This clan contains a variety of DNA-binding domains that contain an immunoglobulin-like fold. It includes the DNA-binding domains of NF-kappaB, NFAT, p53, STAT-1, the T-domain and the Runt domain [1].	2008-09-03 15:50:29	2004-12-10 09:44:45	12	340	136	553	5385	1
+74	CL0074	Matrix	\N	Retroviral matrix superfamily	Bateman A	anon	This clan brings together matrix proteins from a variety of retroviruses.	2008-09-03 15:50:29	2004-12-10 10:07:15	12	41	88	280	38433	1
+75	CL0075	Defensin	\N	Defensin/myotoxin-like superfamily	Bateman A	anon	This clan includes diverse defensins as well as myotoxins.	2008-09-03 15:50:29	2004-12-10 13:40:46	12	146	13	137	1375	1
+76	CL0076	FAD_Lum_binding	\N	Riboflavin synthase/Ferredoxin reductase FAD binding domain	Finn RD	anon	Riboflavin nucleotide coenzymes and flavin adenine dinucleotide (FAD) are essential cofactors for a large number of flavoproteins involved in a diverse set of redox reactions.  There are thought to be four different FAD-binding folds [1].The FAD-binding fold of this clan is a cylindrical  beta-fold. More specifically, the domain forms a flattened six-stranded  antiparallel beta-barrel organised into two orthogonal sheets  (1-2-5 and 4-3-6) separated by one alpha-helix. The cylinder is open  between strands strand 4 and 5. This opening of the cylinder makes space  for the isoalloxazine and ribityl moieties of the FAD, to which hydrogen  bonds are formed from the open edges of the strands. The other end of  the cylinder is covered by the only helix of the domain,  which is essential for the binding of the pyrophosphate groups of the  FAD [1].The structural differences in the FAD-binding domain are  manifested mainly as loops of different length and extra extending  structural elements, which may be important for interactions with their  redox partners [1]. The structural core of all clan members is highly  conserved.	2008-09-03 15:50:29	2004-12-10 14:19:14	11	202	346	5130	31559	1
+77	CL0077	FAD_PCMH	\N	PCMH-like FAD binding	Finn RD	anon	The FAD-binding domains contained in this family fall within the PCMH (p-cresol methyl-hydroxylase) family of FAD binding proteins as defined in [1].  In this family, the structure of the FAD binding domain is comprised of two subdomains.  Both of these subdomains have an alpha-beta fold.  The first subdomain is comprised of three parallel beta strands,  surrounded by alpha helices.  The second subdomain contains five antiparallel beta strands, also surrounded by alpha helices. The junction between these two subdomains forms the FAD bind pocket, where the ligand is bound by hydrogen and van der Waals bonds [1].	2008-09-03 15:50:29	2004-12-10 16:27:25	11	247	229	5425	25538	1
+78	CL0078	DNA_ligase	\N	DNA/RNA ligase superfamily	Bateman A	anon	This superfamily contains both ATP-dependent and NAD dependent DNA ligase enzymes.  The family also includes mRNA capping enzymes.  The members of this clan were shown to be related by sequence in [1].	2008-09-03 15:50:29	2004-12-10 18:04:20	12	72	170	5269	10191	1
+79	CL0079	Cystine-knot	\N	Cystine-knot cytokine superfamily	Bateman A	anon	The cytokine families in this clan have the cystine-knot fold.  In this 6 cysteines form three disulphide bridges that are interlinked.	2008-09-03 15:50:29	2004-12-14 17:03:09	12	253	73	2754	10562	1
+80	CL0080	Mss4-like	\N	Mss4-like superfamily	Bateman A	anon	This clan contains TCTP, Mss4 and SelR families [1].	2008-09-03 15:50:29	2004-12-14 17:24:43	11	51	31	4242	6196	1
+81	CL0081	MBD-like	\N	MBD-like DNA-binding domain	Bateman A	anon	This clan contains proteins with a distinctive three stranded DNA-binding domain [1].	2008-09-03 15:50:29	2004-12-14 17:44:54	12	24	149	2355	10578	1
+82	CL0082	MIF	\N	Tautomerase/MIF superfamily	Bateman A	anon	This clan groups 5-(carboxymethyl)-2-hydroxymuconate isomerase (CHMI) and 4-oxalocrotonate tautomerase (4-OT) with macrophage inhibitory factor (MIF).  Interestingly they all share an amino-terminal proline. Members of this clan for homotrimers [1].	2008-09-03 15:50:29	2004-12-15 11:44:36	11	347	29	3218	5290	1
+83	CL0083	Omega_toxin		Omega toxin-like	Finn RD	anon	This clan contains a set of related small protein toxins and what appears to be the functionally distinct Albumin I domain. All members of this clan have a knottin-like fold.  Additional information about this clan may be found from [1].  	2008-09-03 15:50:29	2004-12-16 13:53:46	14	83	23	290	1853	1
+84	CL0084	ADP-ribosyl	\N	ADP-ribosylation Superfamily	Finn RD	anon	The members of this clan all represent ADP-ribosylating catalytic domains.  The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is  thought to have an "unusual fold".	2008-09-03 15:50:29	2004-12-16 14:31:35	12	208	320	842	3271	1
+85	CL0085	FAD_DHS	\N	DHS-like NAD/FAD-binding domain	Finn RD	anon	The members of this family adopt a Rossmann fold, similar to CLAN:CL0063. However, the members of this family are distinguished in that the FAD/NAD cofactor is bound in the opposite direction.  In this arrangement, the adenosine moiety is found bound at the  second half of the fold.\	   In addition, the conserved GxGxxG motif found in classical NADP binding Rossmann folds is absent.  Finally, another distinguishing characteristic is the formation of an internal hydrogen bond in the FAD molecule [1].	2008-09-03 15:50:29	2004-12-16 15:32:59	13	399	174	5116	30822	1
+86	CL0086	FAD_oxidored	\N	FAD-linked oxidoreductase	Finn RD	anon	The members of this clan adopt a TIM barrel fold, which is reminiscent of flavin mononucleotide binding proteins, rather than one similar to other flavin adenine dinucleotide binding domains. However, the way the FAD cofactor binds in quite different compared to  the binding of FMN in the TIM-barrel structures [1].	2008-09-03 15:50:29	2004-12-16 16:43:38	11	60	30	4179	7837	1
+87	CL0087	Acyl-CoA_dh	\N	Acyl-CoA dehydrogenase, C-terminal domain-like	Finn RD	anon	The Acyl-CoA dehydrogenase FAD binding domain forms an mostly alpha helical domain, comprised of four helices\	arranged in up-and-down bundle. In Acyl-CoA oxidase II this domain appears to have been duplicated.	2008-09-03 15:50:29	2004-12-17 10:15:37	12	254	148	3538	31652	1
+88	CL0088	Alk_phosphatase	\N	Alkaline phosphatase-like	Finn RD	anon	The members of this clan all share a common structure of their catalytic domains, which contain conserved metal binding residues [1].	2008-09-03 15:50:29	2004-12-17 11:25:45	15	217	321	5028	38421	1
+89	CL0089	GlnB-like	\N	GlnB-like superfamily	Finn RD	anon	The members of this clan are characterised by the fact the domains, each comprised of four beta-strand and two alpha helices, tend to form tetrameric structures [1].	2008-09-03 15:50:29	2004-12-17 12:10:20	12	264	47	4170	11982	1
+90	CL0090	Globin	\N	Globin-like	Finn RD	anon	The globin fold is an evolutionary conserved six helical fold that is  found in bacteria and eukaryotes.	2008-09-03 15:50:29	2004-12-17 12:17:06	11	2247	121	4808	13282	1
+91	CL0091	NAD_Ferredoxin	\N	Ferredoxin / Ferric reductase-like NAD binding	Finn RD	anon	The Ferredoxin / Ferric reductase-like NAD binding domain is  adopts a Rossmann like fold.  However, these families have been excluded from the classical NAD(P) binding Rossmann clan (CLAN:CL0063), due to a divergence of the GxGxxG motif.  In this clan, the motif phosphate binding motif is G-T/S-G-A/I-P.  The changes in the motif are a reflection of the different way that the NAD(P)H is bound by this fold and the classical Rossmann fold [1,2].	2008-09-03 15:50:29	2004-12-17 14:54:00	11	192	335	4749	22088	1
+92	CL0092	ADF	\N	Actin depolymerizing Factor	Finn RD	anon	For motile cells such as Amoeba to move, there must be the rapid recycling of their actin cytoskeleton to enable a dynamic change in their shape. Gelsolin (PFAM:PF00626) and Cofilin (PFAM:PF00241) are  two key domain families in this process.  Both of these domain are  structural and functional similar [1,2].  In particular, the beta sheet found at the core of the domain is structurally well conserved, with the helices that surround this sheet less conserved[2]. 	2008-09-03 15:50:29	2004-12-17 17:36:22	11	154	175	529	7818	1
+93	CL0093	Peptidase_CD	\N	Peptidase clan CD	Finn RD	anon	The members of this clan are all endopeptidase that have the catalytic dyad histidine followed by cysteine.  The catalytic histidine is preceded  by a block of hydrophobic residues and a glycine, where as the cysteine is preceded by a block of hydrophobic residues and a glutamine and an alanine. The members with a know structure adopt an alpha/beta fold [1].	2008-09-03 15:50:29	2004-12-21 13:25:00	13	474	1163	1706	9782	1
+94	CL0094	Peptidase_ME	\N	LuxS/MPP-like metallohydrolase	Finn RD	anon	All members of this clan are characterised by a HXXEH motif, which is  is involved in zinc binding.  Furthermore all members adopt an alpha and  beta fold. More specifically, there us a four to six stranded antiparallel beta sheet surrounded by five helices. However, LuxS (PFAM:PF02664) is not a peptidase, although its hydrolytic mechanism of catalysis appears to be conserved [1].	2008-09-03 15:50:29	2004-12-21 13:57:38	11	224	73	4739	30361	1
+95	CL0095	Peptidase_ML	\N	Peptidase Clan ML	Finn RD	anon	This clan contains HybD-like domains.  HybD is a nickel binding  endopeptidase.  Structural and sequences analyses have highlighted the  presence of two highly conserved motifs that are shared with germination proteases and HybD [1].  Members of this clan adopt an alpha/beta fold,  comprised of a central beta sheet, surrounded by alpha helices.	2008-09-03 15:50:29	2004-12-21 15:54:20	12	12	11	1706	3673	1
+96	CL0096	Pept_Inhib_IE	\N	Peptidase Inhibitor Clan IE	Finn RD	anon	The members of this clan are all cystine rich domains, which form a knottin scaffold.  This clan should also contain alpha-amylase but currently this family is a singleton and can not be put into Pfam. Also see [1].	2008-09-03 15:50:29	2004-12-22 12:16:32	11	34	2	22	52	1
+97	CL0097	TypeIII_Chap	\N	Type III secretory system chaperone	Finn RD	anon	The translocation of pathogenic proteins into a host cell is mediated by the type III secretory system. A component of this system is a  chaperone, which binds to the protein which is going to be secreted in the bacterial cytosol and is involved in translocation of the secreted  protein, although the chaperone is not translocated itself. An individual  chaperone associates with one or two specific proteins [1].  There are a large number of type III secretory system chaperones, which are small acidic proteins and exhibit significant sequence divergence.   This clan groups type III secretory system chaperones. Members with a  known structure form small compact globular domains with an alpha-beta(3)- alpha-beta(2)-alpha like organisation [1].	2008-09-03 15:50:29	2004-12-22 12:58:31	11	45	14	1697	3343	1
+98	CL0098	SPOUT	AB_Knot;	SPOUT Methyltransferase Superfamily	Finn RD	anon	A distinct class of methylases that includes the SpoU and TrmD  superfamilies and two superfamilies of predicted methylases defined  by the YbeA and MJ0421 proteins in bacteria and archaea,  respectively [1] (PFAM:PF00588 PFAM:PF01746). SPOUT is  structurally  distinct  compared to more classical methyltransferases [1]. More specifically, the members of this clan form alpha/beta knots. Knots are extremely rare in protein structures as they pose a\	folding problem. The mechanism that allow a domain to be folded as a knot are unclear, but are discussed in [2] and reference therein. All members with known structure form homodimers.	2008-09-03 15:50:29	2004-12-22 15:38:51	13	112	85	5028	32567	1
+99	CL0099	ALDH-like	\N	ALDH-like superfamily	Finn RD	anon	The aldehyde dehydrogenases (ALDHs) are a superfamily of multimeric  enzymes which catalyse the oxidation of a broad range of aldehydes into  their corresponding carboxylic acids with the reduction of their cofactor, NAD(P) into NAD(P)H.  The way that the NAD is bound is distinct from other NAD(P)-dependent oxidoreductases.  The domain represented by this  clan consists of two similar subdomains.	2008-09-03 15:50:29	2004-12-22 15:45:47	12	614	141	5455	48240	1
+100	CL0100	C1q_TNF	\N	C1q and TNF superfamily	Finn RD	anon	The members of the C1q and TNF superfamily are involved in a diverse set  of functions, which include: defense, inflammation, apoptosis, autoimmunity differentiation, organogenesis, hibernation and insulin-resistant\	obesity [1].  Both C1q and TNF domains form a compact jelly-roll beta- sandwich.  The core of these structures are conserved between the two families and corresponds to the detectable sequence similarity. Proteins containing both of these domains, form trimers before they are active.  However, the surfaces of the domains are quite different and  this difference is thought to give rise to the function difference between the clan members[1].  	2008-09-03 15:50:29	2004-12-22 15:46:56	12	294	48	443	3534	1
+101	CL0101	PELOTA	RNA_ribose_bind;	Pelota - RNA ribose binding superfamily	Finn RD	anon	The members of this clan are all involved in binding to ribose sugar of RNA[1].  Indeed, the key RNA binding residues are conserved across the different families [1].  Members of this clan form mixed alpha-helical and beta-sheet structures [1][2].	2012-10-06 18:35:16	2005-01-04 15:00:27	11	212	56	5002	13986	1
+103	CL0103	Gal_mutarotase	\N	Galactose Mutarotase-like superfamily	Bateman A	anon	This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase [1]. All these enzymes act on a sugar substrate.	2008-09-03 15:50:29	2005-01-28 16:18:34	11	539	313	4717	24927	1
+104	CL0104	Glyoxalase	\N	VOC superfamily	Bateman A	anon	This clan contains the VOC metalloenzyme superfamily [1]. The known types of reactions that are catalysed include isomerizations (glyoxalase I), epimerizations (methylmalonyl-CoA epimerase), oxidative cleavage of C-C bonds (extradiol dioxygenase), and nucleophilic substitutions (fosfomycin resistance proteins) [1].	2008-09-03 15:50:29	2005-01-28 18:11:34	12	363	157	4720	43346	1
+105	CL0105	Hybrid	\N	Barrel sandwich hybrid superfamily	Bateman A	anon	This superfamily contains proteins with a hybrid motif [1]. This motif is embedded in structurally diverse proteins.	2008-09-03 15:50:29	2005-01-31 16:15:18	12	394	669	6221	139176	1
+106	CL0106	6PGD_C	\N	6-phosphogluconate dehydrogenase C-terminal-like superfamily	Bateman A	anon	This helical domain is found associated with Rossmann domains.	2008-09-03 15:50:29	2005-01-31 18:34:00	12	232	123	5955	39015	1
+107	CL0107	KOW	\N	KOW domain	Bateman A	anon	This superfamily includes proteins involved in translation that have a KOW like SH3-fold.	2008-09-03 15:50:29	2005-03-18 14:03:54	11	584	79	6487	23716	1
+108	CL0108	Actin_ATPase	\N	Actin-like ATPase Superfamily	Finn RD	anon	The actin-like ATPase domain forms an alpha/beta canonical fold. The domain can be subdivided into 1A, 1B, 2A and 2B subdomains. Subdomains 1A and 1B share the same RNAseH-like fold (a five-stranded beta-sheet decorated by a number of alpha-helices). Domains 1A and 2A are conserved in all members of this superfamily, whereas domain 1B and 2B have a variable structure and are even missing from some homologues [1].  Within the actin-like ATPase domain the ATP-binding site is highly conserved. The phosphate part of the ATP is bound in a cleft between subdomains 1A and 2A, whereas the adenosine moiety is bound to residues from domains 2A and 2B[1].	2008-09-03 15:50:29	2005-03-22 09:34:28	15	1022	508	11461	141414	1
+109	CL0109	CDA		Cytidine deaminase-like (CDA) superfamily	Finn RD, Coin L, Iyer LM, Zhang D, Aravind L	anon	This clan contains both free nucleotide and nucleic acid deaminases that act on adenosine, cytosine, guanine and cytidine, and are  collectively known as the deaminase superfamily.  The conserved fold  consists of a three-layered alpha/beta/alpha structure with 3 helices  and 4 strands in the 2134 order [1,2].This superfamily is further  divided into two major divisions based on the presence of a  helix (helix-4) that renders the terminal strands (strands 4 and 5) either parallel to each other in its presence, or anti-parallel  in its absence [2]. Structurally, the deaminase-like fold is present in four other superfamilies including the JAB-like metalloproteins,  the C-terminal AICAR transformylase-catalyzing domains of PurH,  Tm1506 and the formate dehydrogenase accessory subunit FdhD. The active site of the deaminases is composed of three residues  that coordinate a zinc ion between conserved helices 2 and 3. The  residues are typically found as [HCD]xE and CxxC motifs at the  beginning of helices 2 and 3. The zinc ion activates a water  molecule, which forms a tetrahderal intermediate with the carbon  atom that is linked to the amine group. This is followed by  deamination of the base.  	2008-09-03 15:50:29	2005-03-22 09:57:40	11	208	1010	5319	27014	1
+110	CL0110	GT-A		Glycosyl transferase clan GT-A	Bateman A	anon	This is the GT-A clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].	2008-09-03 15:50:29	2005-03-22 10:54:55	11	713	1496	7680	127750	1
+111	CL0111	GT-C		Glycosyl transferase GT-C superfamily	Bateman A	anon	This is the GT-C clan that contains diverse glycosyltransferases that possess 8-13 predicted transmembrane segments [1].	2008-09-03 15:50:29	2005-03-22 13:52:31	10	19	303	4345	19864	1
+112	CL0112	Yip1		Yip1/YIF1-like	Finn RD, Mistry J	anon	Yip1 and YIF1 are members of an integral membrane complex which bind to Ras-like GTPases and are required for membrane fusion of ER derived vesicles with the Golgi [1].	2008-09-03 15:50:29	2005-03-22 15:32:52	12	4	63	2706	5788	1
+113	CL0113	GT-B	\N	Glycosyl transferase clan GT-B	Bateman A	anon	This is the GT-B clan that contains diverse glycosyltransferases that possess a Rossmann like fold [1].	2008-09-03 15:50:29	2005-03-22 17:19:24	12	539	1601	8102	141567	1
+114	CL0114	HMG-box	\N	HMG-box like superfamily	Bateman A	anon	This clan includes the DNA-binding HMG-box proteins as well as the YABBY-like transcription factors.	2008-09-03 15:50:29	2005-03-23 13:44:43	11	62	241	1493	10953	1
+115	CL0115	Steroid_dh	\N	Steroid oxidoreductase superfamily	Bateman A	anon	This clan includes several enzymes, including steroid dehydrogenases and isoprenylcysteine carboxyl methyltransferase enzymes. These protein contain a varying number of transmembrane regions.	2008-09-03 15:50:29	2005-03-23 14:15:40	11	1	60	2542	7438	1
+116	CL0116	Calycin	\N	Calycin superfamily	Bateman A	anon	The calycin structural superfamily [1-3] includes the lipocalins, the fatty acid-binding proteins (FABPs).	2008-09-03 15:50:29	2005-03-23 14:57:38	12	662	102	3233	10920	1
+117	CL0117	uPAR_Ly6_toxin	\N	uPAR/Ly6/CD59/snake toxin-receptor superfamily	Bateman A	anon	This superfamily contains snake toxins as well as extracellular cysteine rich domains.	2008-09-03 15:50:29	2005-03-30 14:52:26	10	228	28	268	2910	1
+118	CL0118	Ribokinase	\N	Ribokinase-like superfamily	Bateman A	anon	All of these enzymes are phosphotransferases that have an alcohol group as an acceptor (EC:2.7.1.-). However, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMPP kinase) catalyses two phosphorylation reactions: one to a hydroxymethyl group of hydroxymethyl pyrimidine (HMP) and the second to the phosphomethyl group of HMPP [1]. The common structural feature for the enzymes in this superfamily is a central eight-stranded sheet that is flanked by eight structurally conserved helices, five on one side and three on the other [1]. The active site is located in a shallow groove along one edge of the sheet, with the phosphate acceptor hydroxyl group and -phosphate of ATP close together in the middle of the groove, and substrate and ATP binding at the ends [1].	2008-09-03 15:50:29	2005-04-01 13:48:37	11	400	155	5041	42135	1
+121	CL0121	Cystatin		Cystatin-like superfamily	Bateman A	anon	This superfamily includes cystatins and cathelicidins [1]. The cystatin superfamily comprises cysteine protease inhibitors that play key regulatory roles in protein degradation processes. The progenitor of this superfamily was most probably intracellular and lacked a signal peptide and disulfide bridges, much like the extant Giardia cystatin. A primordial gene duplication produced two ancestral eukaryotic lineages, cystatins and stefins. Stefins - included in Pfam:PF00031 - remain encoded by a single or a small number of genes throughout the eukaryotes, whereas the cystatins have undergone a more complex and dynamic evolution through numerous gene and domain duplications [2].	2008-09-03 15:50:29	2005-04-05 16:56:37	11	86	26	392	2322	1
+122	CL0122	UTRA	Chor_lyase;	Chorismate lyase/UTRA superfamily	Bateman A	anon	This clan includes chorismate lyase as well as the UTRA domain	2008-09-03 15:50:29	2005-04-05 17:05:44	10	71	33	3574	14169	1
+123	CL0123	HTH		Helix-turn-helix clan	Bateman A	anon	This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif.	2008-09-03 15:50:29	2005-04-05 17:52:07	17	2812	5699	10949	1020775	1
+124	CL0124	Peptidase_PA		Peptidase clan PA	Bateman A	anon	This clan contains a diverse set of peptidases with the trypsin fold.	2008-09-03 15:50:29	2005-04-06 15:44:18	14	2540	1159	7202	60527	1
+125	CL0125	Peptidase_CA		Peptidase clan CA	Bateman A	anon	This clan includes peptidases with the papain-like fold.	2008-09-03 15:50:29	2005-04-06 17:40:48	14	814	1796	6922	76571	1
+126	CL0126	Peptidase_MA		Peptidase clan MA	Bateman A	anon	Clan MA is one of two zinc-dependent metallopeptidases that contain the HEXXH motif.  The two histidines are zinc ligands. The structures of this clan show the active site is between its two sub-domains.	2008-09-03 15:50:29	2005-04-07 08:52:20	17	981	1676	6188	88418	1
+127	CL0127	ClpP_crotonase		ClpP/Crotonase superfamily	Bateman A	anon	This family includes several peptidases of peptidase clan SK as well as crotonase like proteins.	2008-09-03 15:50:29	2005-04-07 12:12:33	11	1093	331	8610	70137	1
+128	CL0128	vWA-like		von Willebrand factor type A	Finn RD	anon	To add.	2008-09-03 15:50:29	2005-04-07 17:59:38	11	223	1340	4970	35661	1
+129	CL0129	Peptidase_AA	\N	Peptidase clan AA	Bateman A	anon	This clan contains aspartic peptidases, including the pepsins and retropepsins. These enzymes contains a catalytic dyad composed of two aspartates. In the retropepsins one is provided by each copy of a homodimeric protein, whereas in the pepsin-like peptidases these aspartates come from a single protein composed of two duplicated domains.	2008-09-03 15:50:29	2005-04-08 09:36:39	13	1842	629	2629	138509	1
+130	CL0130	Peptidase_AD	\N	Peptidase clan AD	Bateman A	anon	Members of this clan are peptidases that are integral membrane proteins. The catalytic aspartate is in the conserved GXGD motif.	2008-09-03 15:50:29	2005-04-08 11:13:31	10	5	33	3841	6449	1
+131	CL0131	DoxD-like		DoxD-like	Mistry J	anon	The families in this clan are all membrane proteins.  The DoxD family is found on enzymes involved in elemental sulphur oxidation [1].  The other families in this clan are poorly characterised.	2008-09-03 15:50:29	2005-04-08 11:57:52	10	0	56	3235	10608	1
+132	CL0132	AbrB	\N	AbrB/MraZ DNA-binding domain	Bateman A	anon	This superfamily includes the DNA-binding domain of AbrB as well as the presumed DNA-binding protein MraZ (per. comm. A Andreeva and A Murzin).	2008-09-03 15:50:29	2005-04-08 13:53:50	12	50	24	3586	11690	1
+133	CL0133	AT14A-like	\N	AT14A-like	Mistry J	anon	This clan contains plant proteins.  DUF677 family members are AT14A-like proteins that have sequence similarity to fungal, insect and human integrins [1].  The other members of this clan are poorly characterised.	2008-09-03 15:50:29	2005-04-08 14:00:57	10	0	14	26	879	1
+135	CL0135	Arrestin_N-like	\N	Arrestin_N-like	Mistry J	anon	The families in this clan are involved in vacuolar protein trafficking, G protein signal termination and sporulation.  The Arrestin N terminal domain has an Ig-like beta sandwich fold which binds to receptors and impairs their capacity to active G proteins [1].  Arrestins have also been implicated in the endocytosis of receptors and cross talk with other signalling pathways [2].	2008-09-03 15:50:29	2005-04-12 14:27:53	10	34	59	768	5476	1
+136	CL0136	Plasmid_toxin	\N	Plasmid toxin-antitoxin system	Mistry J	anon	The families in this clan are plasmid encoded toxins involved in plasmid maintenance.  The plasmid encodes both a toxin and an antitoxin.  Upon loss of the plasmid the antitoxin is inactivated more rapidly than the toxin.  This allows the toxin to interact with its target thus killing the cell or impeding growth.	2008-09-03 15:50:29	2005-04-14 09:55:24	11	91	44	3558	18077	1
+137	CL0137	HAD		HAD superfamily	Bateman A	anon	This clan represents the haloacid dehalogenase (HAD) superfamily that includes a diverse range of enzymes that use an asp carboxylate as a nucleophile [1].	2008-09-03 15:50:29	2005-04-15 16:57:28	14	780	821	6664	120193	1
+139	CL0139	GADPH_aa-bio_dh	\N	Amino acid biosynthesis and glycosomal dehydrogenase	Mistry J	anon	This clan contains the C terminal domains of dehydrogenase enzymes involved in the biosynthesis of arginine, aspartate and aspartate derived amino acids.  It also contains the C terminal domain of GAPDH, a dehydrogenase involved in glycolysis and gluconeogenesis.	2008-09-03 15:50:29	2005-04-18 13:42:09	10	525	39	9289	24271	1
+140	CL0140	Viral_NABP	\N	Viral nucleic acid binding	Mistry J	anon	This clan contains viral nucleic acid binding protein families. Two of the families in this clan are known to contain zinc finger motifs [1][2].	2008-09-03 15:50:29	2005-04-18 14:24:28	10	0	5	71	578	1
+141	CL0141	MtN3-like		MtN3-like, vesicle-trafficking cargo-receptors	Mistry J	anon	The clan forms a large and diverse family of proteins with seven transmembrane helices, common topology and, most likely, similar function. Their coding genes exist in all eukaryota and in several prokaryota. Some are responsible for metabolic diseases (cystinosis, congenital disorder of glycosylation), others are candidate genes for genetic disorders (cleft lip and palate, certain forms of cancer) or solute uptake and efflux (SWEETs) and many have not yet been assigned a function. Comparison with the properties of well-annotated clan members suggests that the proteins could be involved in protein trafficking and serve as cargo receptors in vesicle trafficking [3].	2008-09-03 15:50:29	2005-04-19 09:24:39	11	0	74	1425	7738	1
+142	CL0142	Membrane_trans		Membrane and transport protein	Mistry J	anon	This clan contains membrane proteins involved in the transport of molecules including amino acids sugars and signalling molecules. It also includes integral membrane cell cycle proteins and some putative ammonia monooxygenases.	2008-09-03 15:50:29	2005-04-20 13:47:04	11	10	78	4928	72098	1
+143	CL0143	B_Fructosidase		Beta fructosidase superfamily	Mistry J	anon	This beta fructosidase superfamily [4] is composed of glycosyl hydrolase families.  The members of this clan adopt a five-bladed beta-propeller fold [2-3]. The beta-fructosidase superfamily is also known as furanosidase superfamily [4].	2008-09-03 15:50:29	2005-04-25 11:24:48	15	191	281	2992	11034	1
+144	CL0144	Periplas_BP	Periplas_BP-like;	Periplasmic binding protein like	Mistry J	anon	This clan includes proteins involved in chemotaxis, membrane transport of sugars and allocrites, and the LacI family transcriptional regulators.  It also includes some antigenic basic membrane lipoproteins.	2008-09-03 15:50:29	2005-04-25 15:04:24	12	462	379	4786	70533	1
+145	CL0145	Golgi-transport	\N	Golgi-transport	Mistry J	anon	This clan contains families that are involved in intracellular transport and signalling.\	\	    Arfaptins are proteins which interact with small GTPases involved in vesicular budding at the Golgi complex.  They form an elongated dimer of three helix coiled coils and are structurally very similar to the BAR domain [1][2]. The Sec34 family is involved in tethering vesicles to the Golgi [3].	2008-09-03 15:50:29	2005-04-25 16:18:47	14	49	165	766	6140	1
+146	CL0146	Herpes_glyco	\N	Herpes glycoprotein	Mistry J	anon	This clan contains herpes envelope glycoproteins [1][2].	2008-09-03 15:50:29	2005-04-25 16:48:44	11	0	3	78	288	1
+147	CL0147	Traffic	\N	Trafficking protein	Mistry J	anon	The members of this clan are involved in protein trafficking. The Sec20 family are integral membrane proteins involved in ER to Golgi transport [1] and V-SNARES are involved in membrane fusion [2].	2008-09-03 15:50:29	2005-04-26 10:46:36	10	7	29	336	2129	1
+148	CL0148	Viral_Gag	\N	Viral Gag protein	Mistry J	anon	This clan contains Gag proteins which are involved in viral assembly and replication [1][2].  	2008-09-03 15:50:29	2005-04-27 12:13:23	10	185	102	374	45347	1
+149	CL0149	CoA-acyltrans	\N	CoA-dependent acyltransferase superfamily	Finn RD	anon	All characterised families in this clan are involved in CoA-dependent acyltransferase. All families have a characteristic HXXXD motif.	2008-09-03 15:50:29	2005-04-27 14:03:23	11	193	1986	4892	38354	1
+151	CL0151	PK_TIM	\N	Pyruvate kinase-like TIM barrel superfamily	Bateman A	anon	This superfamily consists of a number of TIM barrel domains found in enzymes such as pyruvate kinase, malate synthase and citrate lyase.	2008-09-03 15:50:29	2005-05-03 14:40:00	11	507	138	6403	40855	1
+153	CL0153	dUTPase	\N	dUTPase like superfamily	Bateman A	anon	This clan contains dUTPase and many viral proteins that appear to be related. dUTPases are important in virus replication.	2008-09-03 15:50:29	2005-05-04 09:16:52	10	268	42	4817	8241	1
+154	CL0154	C2		C2 superfamily	Bateman A	anon	This superfamily includes C2 domains and C2-like domains.	2008-09-03 15:50:29	2005-05-04 15:46:49	10	222	791	571	27805	1
+155	CL0155	CBM_14_19	\N	Carbohydrate binding domain 14/19 clan	Bateman A	anon	This clan includes two different carbohydrate binding modules.	2008-09-03 15:50:29	2005-05-04 15:50:34	10	1	158	335	6959	1
+156	CL0156	Nucleocapsid	\N	Mononegaviral nucleocapsid superfamily	Bateman A	anon	This clan contains paramyxoviral and ebola type virus nucleocapsid proteins.	2008-09-03 15:50:29	2005-05-04 16:11:33	10	4	2	470	5978	1
+157	CL0157	Kleisin	\N	Kleisin superfamily	Bateman A	anon	The kleisin superfamily includes ScpA, Scc1, Rec8, and Barren [1]. Scc1 interacts with SMC proteins through N- and C-terminal domains to form a ring-like structure [1].	2008-09-03 15:50:29	2005-05-04 16:26:02	10	4	11	3187	3510	1
+158	CL0158	GH_CE	\N	Glycoside hydrolase/deacetylase superfamily	Bateman A	anon	This superfamily contains diverse enzymes that act on carbohydrates including both hydrolases and deacetylases.	2008-09-03 15:50:29	2005-05-04 16:44:41	11	125	249	4786	20178	1
+159	CL0159	E-set		Ig-like fold superfamily (E-set)	Finn RD, Bateman A	anon	This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.	2008-12-15 16:59:57	2005-05-09 16:19:14	15	1072	9593	6497	213896	1
+160	CL0160	Methionine_synt		Cobalamin-independent synthase	Finn RD	anon	The N-terminal and C-terminal cobalamin-independent synthase domains are structurally similar, adopting a TIM beta/alpha barrel. However, the two domain perform functionally different roles. The N-terminal domain and C-terminal domains both define a catalytic cleft in the enzyme.  The N-terminal domain is thought to bind the substrate, in particular, the negatively charged polyglutamate chain.  The N-terminal domain is also thought to stabilise a loop from the C-terminal domain. The C-terminal domain contains the active site residues[1].	2008-09-03 15:50:29	2005-05-09 16:58:23	10	56	28	4455	12453	1
+161	CL0161	GAF	\N	GAF domain-like	Finn RD	anon	A clan of related transcriptional regulator domains.	2008-09-03 15:50:29	2005-05-09 18:32:14	11	220	3047	6850	47618	1
+162	CL0162	FBA	\N	F-box associated	Finn RD	anon	Clan containing related F-box associated families.	2008-09-03 15:50:29	2005-05-09 18:41:19	10	0	47	50	1557	1
+163	CL0163	Calcineurin		Calcineurin-like phosphoesterase superfamily	Bateman A	anon	This clan contains the calcineurin-like phosphoesterases. This clan also includes the apparently inactive homologues from the small DNA polymerase subunits [1].	2008-09-03 15:50:29	2005-05-10 16:59:39	10	274	576	5495	51255	1
+164	CL0164	CUB	\N	CUB clan	Bateman A	anon	This clan contains the CUB domain [1,2].	2008-09-03 15:50:29	2005-05-10 17:23:26	12	31	892	190	13225	1
+165	CL0165	Cache	\N	Cache-like domain	Finn RD	anon	The Cache domain an extracellular domain that is thought to have a role in small-molecule recognition in a wide range of proteins, including the animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors [1].	2008-09-03 15:50:29	2005-05-10 17:26:33	10	40	407	2883	12801	1
+166	CL0166	PRD	\N	PRD domain superfamily	Bateman A	anon	The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator of the BglG family as well as in activators such as MtlR and LevR. The PRD domain is phosphorylated on a conserved histidine residue. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators (Pfam:PF03123, see also comments for this family)) or DNA (for activators), and a duplicated PRD module which is phosphorylated on conserved histidines by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations are thought to modify the stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain.	2008-09-03 15:50:29	2005-05-11 14:46:29	11	9	110	2060	16551	1
+167	CL0167	Zn_Beta_Ribbon		Zinc beta-ribbon	Finn RD	anon	A clan of zinc-binding ribbon domains.	2008-09-03 15:50:29	2005-05-11 16:19:40	14	628	1382	6834	87461	1
+168	CL0168	PAN	\N	PAN-like	Finn RD	anon	PAN domains have significant functional versatility fulfilling diverse biological functions by mediating protein-protein or protein-carbohydrate interactions [1].  These domains contain a hair-pin loop like structure, similar to knottins, but the pattern of disulphide bonds differs.	2008-09-03 15:50:29	2005-05-11 16:56:50	14	59	399	404	5383	1
+169	CL0169	Rep	\N	Rep-like domain	Bateman A	anon	This clan includes replication proteins for viruses and plasmids. This domain is known to bind DNA. The members of this clan have three motifs.  The central HXH is conserved in most families in the clan.	2008-09-03 15:50:29	2005-05-13 18:23:32	10	25	62	3938	11895	1
+170	CL0170	Peptidase_MD	\N	Peptidase MD	Finn RD	anon	This clan is comprised of carboxypeptidases and the N-terminal domain from Sonic hedgehog proteins.  The structure of the latter is similar to the peptidases, but the N-terminal domain of hedgehog has been demonstrate not to be involved in peptidase activity, but is more likely involved in signal transduction [1].	2008-09-03 15:50:29	2005-05-19 09:30:19	10	53	142	3407	9216	1
+171	CL0171	Phospoesterase	\N	inositol polyphosphate 1 phosphatase like superfamily	Bateman A	anon	Members of this clan show metal-dependent / lithium sensitive phosphomonoesterase activity. The clan includes inositol polyphosphate 1 phosphatase and fructose 1,6-bisphosphatase [1]. 	2008-09-03 15:50:29	2005-05-19 17:12:45	10	289	56	4585	15156	1
+172	CL0172	Thioredoxin	Thioredoxin-like;	Thioredoxin-like	Mistry J	anon	This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.	2008-09-03 15:50:29	2005-05-20 15:54:37	16	2327	1079	7198	142836	1
+173	CL0173	STIR	\N	STIR superfamily	Fenech M	anon	Both members of this clan are thought to be involved in TOLL/IL1R-like pathways, by mediating protein-protein interactions between pathway components. The N-termini of SEFIR and TIR domains are similar, but the domains are more divergent towards the C-terminus [1].	2008-09-03 15:50:29	2005-08-11 10:18:06	10	27	1046	1412	7537	1
+174	CL0174	TetR_C	\N	TetR protein, C-terminal domain-like	Fenech M	anon	This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4].	2008-09-03 15:50:29	2005-08-11 10:47:22	9	244	37	2464	10523	1
+175	CL0175	TRASH		TRASH superfamily	Fenech M	anon	TRASH-like domains contain well-conserved cysteine residues that are thought to be involved in metal coordination. These domains are thus expected to be involved in metal trafficking and heavy-metal resistance. It has been suggested that the members adopt a 'treble-clef' fold, with 3/4 beta strands preceding a C-terminal alpha helix [1].	2008-09-03 15:50:29	2005-08-15 13:59:13	10	149	389	2803	12513	1
+176	CL0176	Chemosens_recp	\N	Chemosensory 7tm receptor superfamily	Finn R, Fenech M	anon	The members of this clan are families of various gustatory and odorant receptors. They are described as being seven-transmembrane receptors, and in fact all show characteristic regions of hydrophobicity on the alignment.	2008-09-03 15:50:29	2005-08-15 14:20:45	9	0	50	129	5871	1
+177	CL0177	PBP	\N	Periplasmic binding protein clan	Bateman A	anon	Periplasmic binding proteins (PBPs) consist of two large lobes that close around the bound ligand. This architecture is reiterated in transcriptional regulators, such as the lac repressors. In the process of evolution, genes encoding the PBPs have fused with genes for integral membrane proteins. Thus, diverse mammalian receptors contain extracellular ligand binding domains that are homologous to the PBPs; these include glutamate/glycine-gated ion channels such as the NMDA receptor, G protein-coupled receptors, including metabotropic glutamate, GABA-B, calcium sensing, and pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors [2].	2008-09-03 15:50:29	2005-08-22 13:15:50	15	1664	837	5964	242652	1
+178	CL0178	PUA	\N	PUA/ASCH superfamily	Bateman A	anon	This clan consists of the RNA binding PUA domain and ASCH domain. It also contains uncharacterised protein families.	2008-09-03 15:50:29	2005-08-22 16:11:13	15	169	216	5007	19669	1
+179	CL0179	ATP-grasp	\N	ATP-grasp superfamily	Bateman A	anon	The ATP-grasp domain is found in a wide variety of carboxylate-amine/thiol ligases [1]. It is composed of two subdomains, with ATP being bound in the cleft between the two.	2008-09-03 15:50:29	2005-08-23 14:07:58	13	397	518	7468	61819	1
+181	CL0181	ABC-2	\N	ABC-2-transporter-like clan	Fenech M	anon	These families are similar to the ABC-2 transporter subfamily, as described in [1] (Pfam:PF01061). Members of this family are involved in drug transport and resistance. CcmB protein family (Pfam:PF03379) members are also transporters; they are required for haem export into the periplasm [2].	2008-09-03 15:50:29	2005-08-23 16:06:40	9	3	239	5481	49701	1
+182	CL0182	IT	\N	IT (Ion Transporter) superfamily	Bateman A	anon	This superfamily of secondary carriers specific for cationic and anionic compounds, has been termed the ion transporter (IT) superfamily [1].	2008-09-03 15:50:29	2005-08-23 18:40:04	12	0	126	4842	49966	1
+183	CL0183	PAS_Fold	PAS;	PAS domain clan	Bateman A	anon	This clan contains PAS domains that are found in a wide variety of bacterial signaling proteins.	2008-09-03 15:50:29	2005-08-24 15:20:49	13	311	6949	5998	88093	1
+184	CL0184	DMT		Drug/Metabolite transporter superfamily	Bateman A	anon	This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1].  Many of these families contain a characteristic glycine rich motif close to the C-terminus.	2008-09-03 15:50:29	2005-08-25 11:36:38	10	12	341	5620	114318	1
+186	CL0186	Beta_propeller		Beta propeller clan	Bateman A	anon	This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled.  The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.	2008-09-03 15:50:29	2005-08-26 09:32:54	13	1163	8240	11212	356413	1
+187	CL0187	LysM	\N	LysM-like domain	Fenech M	anon	The LysM domain (Pfam:PF01476) is thought to be a general peptidoglycan-binding module. Although originally described in bacterial proteins, it has been also found in some eukaryotic sequences. It takes up a beta-alpha-alpha-beta conformation, with the beta strands forming an antiparallel beta sheet and the two alpha helices packing on one side of this sheet [1].	2008-09-03 15:50:29	2005-08-26 09:44:43	10	8	614	4599	29820	1
+188	CL0188	CH	\N	Calponin homology domain	Fenech M	anon	The calponin homology (CH) domain is found in a variety of contexts, ranging from proteins involved in signalling pathways to cytoskeletal proteins. They seem to have diverse cellular functions, which are thought to include actin binding, involvement in the MAP kinase signalling pathway, and regulation of GEF activity in Rho family GTPase pathways. Structurally, they are organised into three layers, with two parallel alpha helices in the core being sandwiched between another two helices, one on each side [1].	2008-09-03 15:50:29	2005-08-30 18:32:49	9	107	636	512	11687	1
+189	CL0189	Endonuclease	\N	Endonuclease V-like superfamily	Wuster A	anon	This clan contains DNA repair proteins.  In E. coli endonuclease V initiates DNA repair of deaminated DNA bases and has similarity to motifs required for the catalytic activity of the UvrC endonuclease [1].	2008-09-03 15:50:29	2005-08-31 14:14:38	9	20	27	4568	5628	1
+190	CL0190	HSP20		HSP20-like chaperone superfamily	Fenech M	anon	The small heat shock proteins (sHSPs) prevent protein aggregation during heat shock and oppose regulated cell death. A conserved arginine residue in the HSP20/alpha-crystallin domain (Pfam:PF00011) has in fact been implicated in the development of cataracts and myopathies [1]. The CS family (Pfam:PF04969) includes proteins that are known to bind HSP90 [2], as well as p23 (Swiss:Q15185), which is an HSP90 co-chaperone [3].	2008-09-03 15:50:29	2005-09-01 14:25:02	11	201	170	4085	13158	1
+191	CL0191	POTRA	\N	POTRA domain superfamily	Fenech M	anon	The polypeptide-transport-associated (POTRA) domain is predicted to be organised into three beta-strands and two alpha helices, the latter being found between strands 2 and 3. It is usually found associated with a beta-barrel outer membrane domain. It is thought to have a chaperone-like function; the proteins it is found in are involved in processes as diverse as bacterial septation and protein transport across membranes [1].	2008-09-03 15:50:29	2005-09-01 14:31:22	10	20	53	4354	20069	1
+192	CL0192	GPCR_A		Family A G protein-coupled receptor-like superfamily	Fenech M	anon	This clan contains various seven-transmembrane receptors and related proteins. A major member is Pfam:PF00001, members of which have been considered to be typical members of the rhodopsin superfamily. Many members of this clan are Caenorhabditis proteins, suggesting great expansion of the relevant families in these nematode worms.	2008-09-03 15:50:29	2005-09-02 12:58:56	12	304	924	9484	92105	1
+193	CL0193	MBB		Outer membrane beta-barrel protein superfamily	Bateman A	anon	This clan gathers together a large set of beta barrel membrane proteins.Although these proteins have different numbers of beta strands in the barrel they have significant sequence similarity between families.	2008-09-03 15:50:29	2005-09-05 10:13:31	13	356	515	4665	118601	1
+194	CL0194	DNA_pol_B-like	\N	DNA polymerase B like	Mistry J	anon	DNA polymerases replicate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of a growing chain of DNA.  They use a complementary DNA chain as a template.`	2008-09-03 15:50:29	2005-09-05 13:42:41	9	181	97	2623	7651	1
+195	CL0195	DBL	\N	Duff-binding like superfamily	Bateman A	anon	This clan includes DBL (Duffy-binding like) domains from a variety of plasmodium surface proteins.	2008-09-03 15:50:29	2005-09-05 15:25:46	9	4	55	9	832	1
+196	CL0196	DSRM	\N	DSRM-like clan	Bateman A	anon	This clan contains RNA-binding domains.	2008-09-03 15:50:29	2005-09-08 18:03:50	11	267	170	5456	15069	1
+197	CL0197	GME	\N	GME superfamily	Bateman A, Shirai H	anon	This superfamily contains a number of related enzymes such as AstB, peptidyl-arginine deiminase, arginine deiminase and amidinotransferase [1,2].	2008-09-03 15:50:29	2005-09-15 15:15:35	9	117	27	3437	6472	1
+198	CL0198	HHH		Helix-hairpin-helix superfamily	Bateman A	anon	This superfamily includes Helix-hairpin-helix DNA-binding domains.	2008-09-03 15:50:29	2005-09-16 17:04:15	15	655	587	6368	81507	1
+199	CL0199	DPBB	\N	Double Psi beta barrel glucanase	Bateman A	anon	The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions [1,2]. This clan represents the barwin like barrels.	2008-09-03 15:50:29	2005-09-16 17:23:52	11	29	104	3343	9071	1
+200	CL0200	Prefoldin	\N	Prefoldin	GriffithsJones S, Finn RD, Mistry J	anon	The Prefoldin domain forms a coiled-coil structure that is involved in substrate-binding in the the chaperone co-factor prefoldin (PFD).  Each PFD is assembled from two alpha and four beta subunits. Each alpha subunit contains two, and each beta subunit one, central beta-hairpin that is flanked N- and C-terminally by coiled-coil helices. The N-terminal regions, the prefoldin domain, are found facing into the central cavity of the chaperone. Here exposed hydrophobic patches form an interaction with the substrate (an unfolded protein) [1].	2008-09-03 15:50:29	2005-09-19 13:51:59	9	9	52	526	2970	1
+201	CL0201	Peptidase_SH	\N	Peptidase clan SH	Bateman A	anon	This clan includes the serine peptidase assemblin from herpes virus as well as other viral peptidase families predicted to be related [1].	2008-09-03 15:50:29	2005-09-20 12:38:50	9	47	16	1555	2100	1
+202	CL0202	GBD		Galactose-binding domain-like superfamily	Bateman A	anon	This large superfamily contains beta sandwich domains with a jelly roll topology. Many of these families are involved in carbohydrate recognition. Despite sharing little sequence similarity they do share a weak sequence motif, with a conserved bulge in the C-terminal beta sheet. The probable role of this bulge is in bending of the beta sheet that contains the bulge. This enables the curvature of the sheet forming the sugar binding site [1].	2008-09-03 15:50:29	2005-09-20 16:50:13	10	807	2917	4159	38880	1
+203	CL0203	CBD	\N	Carbohydrate binding domain superfamily	Bateman A	anon	This superfamily includes several carbohydrate binding domains. These domains have a beta sandwich structure.	2008-09-03 15:50:29	2005-09-21 11:02:43	11	97	423	950	3904	1
+204	CL0204	Adhesin	\N	Bacterial adhesin superfamily	Bateman A	anon	This superfamily includes a variety of bacterial adhesins that have a jelly-roll beta-barrel fold [1]. These domains are involved in sugar recognition.	2008-09-03 15:50:29	2005-09-21 11:17:50	10	156	136	1489	19890	1
+205	CL0205	Di-copper	\N	Di-copper centre-containing domain	Bateman A	anon	This superfamily includes tyrosinases and hemocyanins that share a di-copper centre [1].	2008-09-03 15:50:29	2005-09-23 12:59:27	10	106	90	1801	4482	1
+206	CL0206	TRB	\N	Transcriptional repressor beta-barrel domain	Bateman A	anon	This beta-barrel domain is found at the C-terminus of a variety of transcriptional repressor proteins.	2008-09-03 15:50:29	2005-09-23 14:02:56	10	132	32	4239	8501	1
+207	CL0207	Rhomboid-like	\N	Integral membrane protein / protease	Mistry J	anon	This clan contains proteins from both bacteria and eukaryotes. The Rhomboid protein is an intramembrane serine protease which is involved in epidermal growth factor (EGF)-dependent signalling pathways [1]. The DER1 family is involved in degradation of misfolded ER proteins [2].	2008-09-03 15:50:29	2005-12-01 11:27:30	9	16	91	4052	9025	1
+208	CL0208	UBC	\N	Ubiquitin conjugating enzyme like superfamily	Bateman A	anon	This superfamily includes a diverse set of proteins that bind to ubiquitin [1].	2008-09-03 15:50:29	2005-12-02 15:22:57	10	294	238	870	12063	1
+209	CL0209	Bet_V_1_like	\N	Bet V 1 like	Mistry J	anon	The Bet_V_I family is composed of sequences related to the major Birch (Betula verrucose) pollen antigen Betv1.  This allergen is known to cause hayfever, dermatitis, asthma and occasionally anaphylactic shock.  The other families in this clan share the same structure as Betv1 which is composed of antiparallel beta sheets and alpha helices.  There is a cavity between the beta sheet and a long C terminal helix.  The cavity appears to play roles in the binding of lipid molecules [1][2][3] which seems a common feature of the families in this clan.	2008-11-07 17:26:25	2005-12-02 17:50:32	10	443	245	4418	23609	1
+210	CL0210	HNOX-like	\N	Heme NO and oxygen binding like	Mistry J	anon	This clan contains families that bind small molecules and are predominantly involved in signalling.  Members include the heme NO binding domain.  This domain is related to soluble guanylate cyclases and is mainly alpha helical in structure.\	      Other members of this clan include V4R, which is predicted to be a small molecule binding domain, and a domain often found adjacent to this that is found on activators of aromatic catabolism, and on signalling molecules.	2008-09-03 15:50:29	2005-12-06 09:55:10	10	54	47	793	1692	1
+212	CL0212	SNARE	\N	SNARE-like superfamily	Bateman A	anon	This clan includes part of the SNARE like superfamily.	2008-09-03 15:50:29	2005-12-08 17:07:43	8	44	96	372	5553	1
+213	CL0213	ShK-like	\N	Sea anemone toxin k like	Mistry J	anon	Members of this clan include the Crisp domain which is involved in ryanodine receptor Ca2+ signalling, and the ShK domain which is named after the ShK channel inhibitor toxin.  Both domains are cysteine rich and contain multiple disulphide bonds [1][2][3].	2008-09-03 15:50:29	2006-01-03 16:32:02	8	27	121	194	2516	1
+214	CL0214	UBA	\N	UBA superfamily	Bateman A	anon	This superfamily includes domains related to the UBA domain. These domains are often involved in ubiquitin binding.	2008-09-03 15:50:29	2006-01-05 15:54:42	12	148	350	5009	18121	1
+217	CL0217	Rotavirus_VP7	\N	Rotavirus VP7 protein	Bateman A	anon	This clan consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer [1].	2008-09-03 15:50:29	2006-01-24 14:08:46	8	28	2	702	4849	1
+218	CL0218	ox_reductase_C	\N	Oxidoreductase C terminal like	Mistry J	anon	This clan contains the C terminal region of oxidoreductase proteins and putative oxidoreductase proteins.  Families in this clan form an alpha/beta structure and are usually found adjacent to an N terminal Rossman fold.	2008-09-03 15:50:29	2006-01-26 11:16:09	11	193	37	3633	12363	1
+219	CL0219	RNase_H	\N	Ribonuclease H-like superfamily	Bateman A	anon	This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H.	2008-09-03 15:50:29	2006-01-31 17:56:29	13	1007	2352	7614	190937	1
+220	CL0220	EF_hand	\N	EF-hand like superfamily	Bateman A	anon	The EF hand is a calcium binding domain found in a wide variety of proteins [1].	2008-09-03 15:50:29	2006-02-01 09:23:33	11	1170	2215	3113	56360	1
+221	CL0221	RRM	\N	RRM-like clan	Bateman A	anon	This clan contains families that are related to the RNA recognition motif domains.  However, not all these families are RNA binding.	2008-09-03 15:50:29	2006-03-05 12:30:44	10	736	1162	5818	73704	1
+222	CL0222	MviN_MATE	\N	MviN, MATE-like superfamily	Bateman A	anon	This superfamily consists of a variety of integral membrane protein families. The MATE family are known to be transporters. Other proteins have been implicated in virulence and polysaccharide biosynthesis.	2008-09-03 15:50:29	2006-03-05 13:21:19	7	4	109	5014	53746	1
+223	CL0223	MACRO	\N	MACRO domain superfamily	Bateman A	anon	This superfamily includes the Macro domain as well as the amino terminal domain from peptidase M17 proteins.	2008-09-03 15:50:29	2006-03-06 10:58:15	7	147	130	4353	8980	1
+224	CL0224	DHQS	\N	Dehydroquinate synthase-like superfamily	Bateman A	anon	This superfamily includes Dehydroquinate synthase and Iron containing alcohol dehydrogenase which have a similar active site organisation [1].	2008-09-03 15:50:29	2006-03-06 13:57:58	7	116	47	4875	18804	1
+225	CL0225	FtsL	\N	FtsL-like superfamily	Bateman A	anon	This clan includes two proteins that are known to interact, FtsL and DivIC which are part of a trimeric complex with DivIB [2]. DivIC and FtsL are bacterial proteins essential for cell division.	2008-09-03 15:50:29	2006-03-06 15:46:31	7	0	9	3920	6384	1
+226	CL0226	M6PR	\N	Mannose 6-phosphate receptor	Bateman A	anon	This clan includes cation dependent and independent mannose 6-phosphate receptors.	2008-09-03 15:50:29	2006-03-06 16:32:14	8	48	95	319	2892	1
+227	CL0227	Enolase_N	\N	Enolase N-terminal domain-like superfamily	Bateman A	anon	This domain is found at the N-terminus of the catalytic Tim barrel-like domain in enolase and other enzymes.	2008-09-03 15:50:29	2006-03-06 16:37:34	8	887	42	5636	14408	1
+228	CL0228	Acyltransferase		Acyltransferase clan	Bateman A	anon	This clan includes several families of related acyltransferases.	2008-09-03 15:50:29	2006-03-06 16:43:34	7	2	169	4885	24321	1
+229	CL0229	RING	\N	Ring-finger/U-box superfamily	Bateman A	anon	This clan includes the Ring zinc finger domains as well as the U-box domain that appears to have lost the zinc coordinating cysteine residues [1].	2008-09-03 15:50:29	2006-03-06 16:54:46	10	159	1983	4407	49901	1
+230	CL0230	HO	\N	Heme oxygenase-like superfamily	Bateman A	anon	This clan includes the Heme oxygenase family as well as the TENA/THI-4/PQQC family that are less well characterised [2].	2008-09-03 15:50:29	2006-03-06 16:57:26	7	195	41	2847	5166	1
+231	CL0231	MazG	\N	all-alpha NTP pyrophosphohydrolase superfamily	Bateman A	anon	This superfamily includes MazG, HisE and dimeric dUTPases (Not yet in Pfam) [1].	2008-09-03 15:50:29	2006-03-06 17:03:44	8	112	46	4768	13122	1
+232	CL0232	NifU	\N	NifU C-terminal domain-like superfamily	Bateman A	anon	This clan includes the C-terminal domain of NifU as well as a large family of uncharacterised domains.	2008-09-03 15:50:29	2006-03-06 17:10:22	7	28	49	4450	9837	1
+233	CL0233	SufE_NifU	\N	SufE/NifU superfamily	Bateman A	anon	This clan includes iron sulfur cluster assembly proteins.	2008-09-03 15:50:29	2006-03-06 17:18:24	7	30	26	4741	7304	1
+234	CL0234	CTPT	\N	CTP transferase-like superfamily	Bateman A	anon	This clan includes the integral membrane CTP transferase family as well as a large family of uncharacterised proteins that may also function as nucleotidyltransferases.	2008-09-03 15:50:29	2006-03-06 17:30:58	7	0	20	4821	6518	1
+235	CL0235	PspA	\N	PspA/ESCRT-III	Bateman A	anon	This clan includes PspA like proteins that are transcriptional activators as well as Snf7, a protein involved in cellular trafficking.	2008-09-03 15:50:29	2006-03-07 09:10:43	8	24	36	2194	5578	1
+236	CL0236	PDDEXK		PD-(D/E)XK nuclease superfamily	Bateman A	anon	This clan includes a large number of nuclease families related  to holliday junction resolvases [1,2].	2012-10-03 14:09:06	2006-03-07 10:09:50	16	584	895	6041	71985	1
+237	CL0237	HD_PDEase	\N	HD/PDEase superfamily	Bateman A	anon	This clan includes a range of phosphohydrolase enzymes with a common helical fold.	2008-09-03 15:50:29	2006-03-07 17:08:35	7	446	682	5155	45938	1
+238	CL0238	PP2C	\N	PP2C-like superfamily	Bateman A	anon	This clan includes the PP2C family of phosphatases as well as the SpoIIE family.  This suggests SpoIIE proteins may also be phosphatases.	2008-09-03 15:50:29	2006-03-08 17:11:21	7	81	723	3947	17476	1
+239	CL0239	Insulin	\N	Insulin-like superfamily	Bateman A	anon	This superfamily includes the insulin like hormones.	2008-09-03 15:50:29	2006-03-09 13:10:30	7	895	8	341	1563	1
+240	CL0240	PFK	\N	PFK-like superfamily	Bateman A	anon	This clan includes two SCOP superfamilies. Strong similarities between NAD kinases, DAG kinase, sphingosine kinase and PFK have previously been shown[1].	2008-09-03 15:50:29	2006-03-09 16:35:37	7	146	173	5088	20115	1
+241	CL0241	ABC_membrane	\N	ABC transporter membrane domain clan	Bateman A	anon	This clan includes families that are the membrane components of ABC transporter complexes. In general these regions are composed of six transmembrane helices [1].	2008-09-03 15:50:29	2006-03-09 17:38:52	7	22	211	5258	54224	1
+242	CL0242	DNA_primase_lrg	\N	DNA primase large subunit like	Mistry J	anon	This clan contains the large subunit of archaeal and eukaryotic DNA primase, an enzyme which synthesises the oligoribonucleotide primers essential to DNA replication.  The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays a roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase [1].  The clan also contains the Lef-2 family, which is required for the expression of late genes.  There is some evidence to suggest that LEF2 binds to both DNA and the DNA primase small subunit LEF-1 [3].	2008-09-03 15:50:29	2006-04-21 14:57:17	8	11	11	506	609	1
+243	CL0243	AEP		Archaeo-eukaryotic primase	Mistry J	anon	This clan includes the small subunit of 2 and eukaryotic DNA primase, and primase-helicase proteins from bacteriophages and plasmids.  All known cellular life forms use primases to synthesis a short RNA primer which is extended during DNA replication by a polymerase.  Bacterial DNA primase adopts a different fold to archaeal and eukaryotic primases and belongs to a different superfamily.	2008-09-03 15:50:29	2006-04-24 16:40:55	9	21	52	1612	2766	1
+244	CL0244	PGBD	\N	PGBD superfamily	Bateman A	anon	This clan consists of small putative peptidoglycan binding domains composed of three alpha helices.	2008-09-03 15:50:29	2006-05-16 17:51:06	8	23	345	3348	11009	1
+245	CL0245	EDD	\N	EDD superfamily	Bateman A	anon	The EDD superfamily was identified as an evolutionarily conserved domain (EDD) common to three different folds: mannose transporter EIIA domain (EIIA-man), dihydroxyacetone kinase (Dak), and DegV [1]. Both Dak and EIIA-man perform similar phosphotransfer reactions, suggesting a phosphotransferase activity for the DegV-like family of proteins, whose function other than lipid binding revealed in the crystal structure remains unknown [1].	2008-09-03 15:50:29	2006-05-17 09:35:18	8	92	62	3559	18450	1
+246	CL0246	ISOCOT_Fold	NagB-like;	Isomerase,CoA transferase & Translation initiation factor Superfamily	Bateman A, Anantharaman V	anon	This superfamily contains a variety of enzymes and non-enzymatic  ligand binding domains.	2008-09-03 15:50:29	2006-05-17 13:20:27	7	279	161	5233	53370	1
+247	CL0247	2H	\N	2H phosphoesterase superfamily	Bateman A	anon	This clan includes a number of phosphoesterases that contain an internal duplication.	2008-09-03 15:50:29	2006-05-17 15:53:15	8	24	78	2901	4878	1
+248	CL0248	ParBc	\N	ParB-like superfamily	Bateman A	anon	This superfamily includes nucleases related to ParB as well as uncharacterised proteins.	2008-09-03 15:50:29	2006-06-02 16:12:35	7	28	97	4788	13574	1
+249	CL0249	Phage_tail_L	\N	Phage minor tail protein L clan	Bateman A	anon	This clan includes the phage minor tail protein L as well as a group of uncharacterised proteins that are also presumably phage components.	2008-09-03 15:50:29	2006-06-02 18:35:28	7	0	7	706	1564	1
+250	CL0250	GAD	\N	GAD domain superfamily	Bateman A	anon	This domain is found as an insert within aspartyl-tRNA synthetase as well as GatB proteins.	2008-09-03 15:50:29	2006-07-27 15:00:10	6	16	17	4522	4847	1
+251	CL0251	MORN	\N	MORN repeat	Mistry J	anon	The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).\	A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis as dynamic component of cell division apparatus [1].\	It has been hypothesised to function as a linker protein between certain membrane regions and the parasite's cytoskeleton [1].	2008-09-03 15:50:29	2006-07-31 12:59:47	7	27	334	1412	30871	1
+252	CL0252	NfeD-like	\N	NfeD like	Mistry J	anon	This clan includes the NfeD family which contains several proteins described as nodulation efficiency protein D (NfeD). The nfe genes (nfeA, nfeB, and nfeD) are involved in the nodulation efficiency and competitiveness of the Sinorhizobium meliloti strain GR4 on alfalfa roots [1]. The specific function the NfeD family is unknown although it is unlikely that NfeD is specifically involved in nodulation as the family contains several different archaeal and bacterial species most of which are not symbionts.	2008-09-03 15:50:29	2006-07-31 13:35:37	6	3	8	2902	4042	1
+254	CL0254	THDP-binding		Thiamin diphosphate-binding superfamily	Mistry J, Bateman A	anon	This clan includes pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases.	2008-09-03 15:50:29	2006-07-31 17:23:48	8	598	271	5650	93998	1
+255	CL0255	ATP_synthase		ATP synthase F0 subunit	Mistry J	anon	This clan contains subunits of the F0 complex of ATP-synthase. The F0 complex is the non-catalytic unit of ATPase and is involved in proton translocation across membranes.	2008-09-03 15:50:29	2006-08-01 13:45:46	8	29	78	10710	23627	1
+256	CL0256	Enolase_TIM	\N	Enolase like TIM barrel	Mistry J	anon	This clan contains enzymes which adopt a TIM barrel fold.	2008-09-03 15:50:29	2006-08-01 15:00:35	6	1004	67	6025	21543	1
+257	CL0257	Acetyltrans	Acetyltrans-like;	N-acetyltransferase like	Mistry J	anon	This clan contains families related to N-acetyltransferases. N-acetyltransferases catalyse the transfer of acetyl groups from acetyl-CoA to arylamines.	2008-09-03 15:50:29	2006-08-02 14:16:08	8	664	967	6524	128815	1
+258	CL0258	DALR	\N	DALR superfamily	Bateman A	anon	Members of this family are anticodon binding domains from various tRNA synthetases.	2008-09-03 15:50:29	2006-08-17 18:00:51	6	13	28	4898	11747	1
+259	CL0259	OstA	\N	OstA superfamily	Bateman A	anon	This superfamily includes the OstA family as well as a large family of uncharacterised proteins.	2008-09-03 15:50:29	2006-08-22 10:05:45	6	11	32	2407	6093	1
+260	CL0260	NTP_transf	\N	Nucleotidyltransferase superfamily	Bateman A	anon	This clan contains a diverse set of nucleotidyltransferase enzymes.	2008-09-03 15:50:29	2006-08-22 16:46:46	7	338	577	5508	42917	1
+261	CL0261	NUDIX		NUDIX superfamily	Bateman A	anon	This superfamily contains the NUDIX family and one related family.	2008-09-03 15:50:29	2006-08-24 18:58:30	6	360	321	5236	48986	1
+262	CL0262	Trigger_C	\N	Trigger factor/SurA domain	Bateman A	anon	This helical domain is found in two families of chaperones.  It is found at the N terminus of the SurA proteins and at the C-terminus of the trigger factors where presumably it shares a common but as yet unknown function.	2008-09-03 15:50:29	2006-08-30 10:54:44	6	20	54	4464	9322	1
+263	CL0263	His-Me_finger		His-Me finger endonuclease superfamily	Bateman A	anon	This superfamily defined originally by SCOP contains a diverse range of endonucleases. Later Grishin identified the MH1 domain as belonging to the superfamily [1].	2008-09-03 15:50:29	2006-09-06 17:41:01	7	141	462	5328	22334	1
+264	CL0264	SGNH_hydrolase	\N	SGNH hydrolase superfamily	Bateman A	anon	This superfamily contains a diversity of hydrolytic enzyme activities.	2008-09-03 15:50:29	2006-09-07 09:23:58	6	122	427	4610	21200	1
+265	CL0265	HIT	\N	HIT superfamily	Bateman A	anon	The HIT superfamily are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides [1].	2008-09-03 15:50:29	2006-11-09 16:05:44	6	147	99	4930	15333	1
+266	CL0266	PH	\N	PH domain-like superfamily	Bateman A	anon	Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.	2008-09-03 15:50:29	2006-11-10 10:42:30	8	419	1526	2586	41992	1
+267	CL0267	S11_L18p	\N	Ribosomal protein S11/L18p superfamily	Bateman A	anon	This superfamily includes two ribosomal proteins S11 and L18p as well as a domain from eukaryotic peptide chain release factor. This superfamily is likely to share an RNA-binding function.	2008-09-03 15:50:29	2006-11-10 14:46:27	7	451	37	5925	12981	1
+268	CL0268	Pec_lyase-like	Pec_lyase; Pectate_lyase;	Pectate lyase-like beta helix	Bateman A	anon	This superfamily all contain a right handed beta helix similar to that first found in pectate lyase [1].	2008-09-03 15:50:29	2006-11-10 15:10:57	6	217	1681	4399	45644	1
+269	CL0269	Maf	\N	Maf/Ham1 superfamily	Bateman A	anon	This superfamily includes the Maf-like proteins and ITPases related to YjjX [1].	2008-09-03 15:50:29	2006-11-10 17:10:08	7	21	29	3802	6399	1
+270	CL0270	Iso_DH	\N	Isocitrate/Isopropylmalate dehydrogenase-like superfamily	Bateman A	anon	This superfamily of enzymes form dimers and have an active site between the two halves.	2008-09-03 15:50:29	2006-11-10 17:50:17	6	323	67	6496	27220	1
+271	CL0271	F-box	\N	F-box-like domain	Bateman A	anon	This clan includes classical F-boxes and the PRANC domain found in pox ankyrin proteins.	2008-09-03 15:50:29	2006-11-22 13:28:07	6	29	805	512	18595	1
+272	CL0272	RGS	\N	RGS-like superfamily	Bateman A	anon	This clan includes RGS domains that possess an alpha helical fold.	2008-09-03 15:50:29	2006-11-27 17:23:03	6	92	152	303	4401	1
+273	CL0273	CYTH	\N	CYTH-like phosphatase superfamily	Bateman A	anon	CyaB like adenylyl cyclase and the mammalian thiamine triphosphatases define a novel superfamily of catalytic domains called the CYTH domain that is present in all three superkingdoms of life. The catalytic core of these enzymes contain a novel alpha beta scaffold with 6 conserved acidic residues and 4 basic residues [1].	2008-09-03 15:50:29	2006-12-05 13:50:23	6	48	23	3410	3949	1
+274	CL0274	WRKY-GCM1	\N	WRKY-GCM1 superfamily	Bateman A	anon	WRKY and GCM1 are metal chelating DNA-binding domains (DBD) which share a four stranded fold [1]. We present evidence that they share a stabilising core, which suggests a possible origin from a BED finger-like intermediate that was in turn ultimately derived from a C2H2 Zn-finger domain [1].	2008-09-03 15:50:29	2006-12-05 13:57:43	7	5	215	443	6439	1
+275	CL0275	HAS-barrel	\N	HAS-barrel superfamily	Bateman A	anon	The HAS barrel is named after HerA-ATP Synthase. In ATP synthases, this domain is implicated in the assembly of the catalytic toroid and docking of accessory subunits, such as the subunit of the ATP synthase complex. Similar roles in docking of the functional partner, the NurA nuclease, and assembly of the HerA toroid complex appear likely for the HAS-barrel of the HerA family [1].	2008-09-03 15:50:29	2006-12-06 11:13:24	8	401	41	11124	22310	1
+276	CL0276	Nucleot_cyclase	\N	Nucleotide cyclase superfamily	Bateman A	anon	This superfamily includes adenylyl cyclase and the GGDEF domain [1].	2008-09-03 15:50:29	2006-12-06 14:41:38	7	119	2538	3679	52683	1
+277	CL0277	FAD-oxidase_C	\N	FAD-linked oxidase C-terminal domain superfamily	Bateman A	anon	This clan consists of a duplicated subdomain in a variety of FAD-liked oxidase/dehydrogenase enzymes.	2008-09-03 15:50:29	2006-12-07 10:48:02	6	129	128	3530	14475	1
+278	CL0278	AIG2	\N	AIG2/ChaC-like superfamily	Bateman A	anon	The structure consists of a five-stranded beta-barrel surrounded by two alpha-helices and a small beta-sheet.\	Conservation of residues in a hydrophilic cavity able to bind small ligands in some members suggests that this may also serve as an active site.	2008-09-03 15:50:29	2006-12-12 14:39:36	7	20	48	2219	4183	1
+279	CL0279	GatB_YqeY	\N	YqeY-like superfamily	Bateman A	anon	This superfamily includes a domain from GatB as well as one from YqeY. Although being structurally distinct they share a common sequence relationship.	2008-09-03 15:50:29	2007-01-24 12:42:11	6	38	17	4060	6337	1
+280	CL0280	PIN	\N	PIN domain superfamily	Bateman A	anon	This superfamily contains a variety of nuclease enzymes, including PIN domains and the FLAP exonucleases.	2008-09-03 15:50:29	2007-01-25 17:50:12	6	117	241	5231	29721	1
+281	CL0281	CCT	\N	CCT like-motif	Bateman A	anon	This clan includes the CCT motif as well as a related motif that is similar to the first half of the CCT motif.	2008-09-03 15:50:29	2007-01-29 13:51:28	6	21	28	152	1759	1
+282	CL0282	Serum_albumin	\N	Serum albumin superfamily	Bateman A	anon	This superfamily includes serum albumin and related families.	2008-09-03 15:50:29	2007-01-30 15:32:33	6	113	8	71	738	1
+283	CL0283	LigB	\N	LigB-like superfamily	Bateman A	anon	This clan includes the LigB subunit of the aromatic ring opening dioxygenase LigAB [1]. The clan also includes the Memo-like proteins.	2008-09-03 15:50:29	2007-02-12 17:08:37	6	13	17	2285	4015	1
+284	CL0284	Allatostatin	\N	Allatostatin superfamily	Mistry J	anon	Allatostatins are pleiotropic neuropeptides.  In some insects they are known to inhibit the synthesis of juvenile hormone, an important regulator of development and reproduction.  The full role of allatostatins in hormone production is still unclear [1].	2008-09-03 15:50:29	2007-05-04 14:22:41	5	0	16	41	455	1
+285	CL0285	YycI_YycH	\N	YycI/YycH superfamily	Bateman A	anon	Both, YycH and YycI are always found in a pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Structural studies show that these two protein families share two related domains.	2008-09-03 15:50:29	2007-05-14 11:16:06	6	13	4	723	1328	1
+286	CL0286	GCS	\N	gamma-glutamylcysteine synthetase/glutamine synthetase clan	Bateman A, Pei J	anon	This clan represents a superfamily of carboxylate-amine/ammonia ligases [1] that includes Gamma-Glutamylcysteine synthetase (gamma-GCS) and glutamine synthetase (GS). Gamma-Glutamylcysteine synthetase (gamma-GCS) catalyses the first step in the de novo biosynthesis of glutathione.	2008-09-03 15:50:29	2007-08-10 14:04:49	5	394	88	9114	22193	1
+287	CL0287	Transthyretin	\N	Transthyretin superfamily	Bateman A	anon	This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.	2008-09-03 15:50:29	2007-08-14 16:23:44	6	929	1227	4080	40864	1
+288	CL0288	DAP_epimerase	\N	DAP epimerase superfamily	Bateman A	anon	This superfamily includes DAP epimerase and proline racemase as well as the PrpF protein. It has been suggested that this fold may have evolved from the HotDog fold [1].	2008-09-03 15:50:29	2007-08-17 11:58:37	5	61	43	3955	13393	1
+289	CL0289	FBD	\N	Folate binding domain	Bateman A	anon	This folate binding domain is found in the GCV T protein as well as the sarcosine oxidase gamma subunit [1].	2008-09-03 15:50:29	2007-08-17 13:17:41	5	63	59	4863	12811	1
+290	CL0290	EPT_RTPC	\N	EPT/RTPC-like superfamily	Bateman A	anon	This superfamily includes Enolpyruvate transferase (EPT) and RNA 3'-terminal phosphate cyclase (RTPC).	2008-09-03 15:50:29	2007-08-17 13:33:07	5	195	54	4992	12126	1
+291	CL0291	KNTase_C		Nucleotidyltransferase substrate binding domain	Bateman A	anon	This alpha helical domain is found associated with a variety of nucleotidyltransferase domains.	2008-09-03 15:50:29	2007-08-20 15:49:55	6	35	91	3566	11834	1
+292	CL0292	LysE		LysE transporter superfamily	Bateman A	anon	This clan includes a diverse range of transporter families [1].	2008-09-03 15:50:29	2007-10-04 12:03:53	5	0	68	4993	52424	1
+293	CL0293	CDC	\N	Cholesterol-dependent cytolysin superfamily	Bateman A	anon	This superfamily includes the MACPF domain as well as the Cholesterol-dependent cytolysins [1].	2008-09-03 15:50:29	2007-10-19 12:42:17	5	21	68	720	2339	1
+294	CL0294	Sec10	\N	Sec10-like superfamily	Bateman A	anon	This superfamily includes large proteins that are parts of the conserved oligomeric Golgi complex and exocyst complex.	2008-09-03 15:50:29	2007-11-20 17:02:32	5	0	34	298	1198	1
+295	CL0295	Vps51		Vps51 domain superfamily	Bateman A	anon	This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.	2008-09-03 15:50:29	2007-11-20 17:11:52	6	11	168	380	6736	1
+296	CL0296	GroES	\N	GroES-like superfamily	Bateman A	anon	This superfamily includes the GroES protein as well as the N-terminal GroES-like domain from Alcohol dehydrogenase.	2008-09-03 15:50:29	2008-02-08 16:40:31	4	569	527	6115	49027	1
+297	CL0297	PhoU	\N	PhoU-like superfamily	Bateman A	anon	This superfamily includes PhoU and its relatives that contain a three helical bundle domain structure.	2008-09-03 15:50:29	2008-02-08 17:40:34	4	21	32	4083	13356	1
+298	CL0298	tRNA_bind_arm	\N	tRNA-binding arm superfamily	Bateman A	anon	This domain is found in Phe and Ser tRNA synthetases at the N-terminus, and at the C-terminus of Val tRNA synthetase. The domain is composed of two helices.	2008-09-03 15:50:29	2008-02-12 16:57:18	4	43	35	4877	13679	1
+299	CL0299	Peptidase_SF	\N	Peptidase clan SF	Mistry J, Rawlings N	anon	This clan includes the peptidase S24 and S26 families.  These families adopt a mainly beta fold.  Members of the family S24 have an additional C-terminal domain containing a bundle of three helices presumably important for binding DNA.	2008-09-03 15:50:29	2008-02-25 12:55:51	4	47	75	5096	20383	1
+300	CL0300	TAT	\N	Twin-Arginine Translocation Motif	Bateman A	anon	This motif is found in a wide range of secreted proteins. It is named after the conserved pair of arginines that is followed by a hydrophobic stretch.	2008-09-03 15:50:29	2008-02-29 15:32:23	4	26	172	1437	2441	1
+301	CL0301	PA14	\N	PA14 superfamily	Bateman A	anon	This clan includes the PA14 domain and related families.	2008-09-03 15:50:29	2008-03-03 17:31:48	5	32	336	731	2126	1
+302	CL0302	Arginase	\N	Arginase/deacetylase superfamily	Bateman A	anon	This superfamily includes arginase enzymes as well as histone deacetylases and related enzymes [1].	2008-09-03 15:50:29	2008-04-30 14:26:28	5	410	86	3456	11530	1
+303	CL0303	H2TH	\N	Helix-two-turns-helix superfamily	Bateman A	anon	This domain is thought to play a role in binding nucleic acids. It is DNA binding in nucleases and RNA-binding in ribosomal S13.	2008-09-03 15:50:29	2008-05-28 16:24:30	4	289	53	5430	13968	1
+304	CL0304	CheY	\N	CheY-like superfamily	Bateman A	anon	This clan includes the CheY-like response regulators from bacteria [1-2].	2008-09-03 15:50:29	2008-06-04 14:50:30	4	475	3478	5545	154594	1
+305	CL0305	PTH2	\N	Peptidyl-tRNA hydrolase II superfamily	Bateman A	anon	This clan includes Peptidyl-tRNA hydrolase II as well as a large family of uncharacterised proteins called DUF2000. A structure for DUF2000 shows a similar structure to PTH2. It is not clear if the DUF2000 family are also Peptidyl-tRNA hydrolases. Both families contain a conserved positively charged residue close to the amino terminus that may be part of the active site.	2008-09-03 15:50:29	2008-06-05 14:00:28	4	24	15	963	1328	1
+306	CL0306	HeH	\N	LEM/SAP HeH motif	Bateman A	anon	This superfamily includes protein domains with the helix-extended loop-helix (HeH) structure.	2008-09-03 15:50:29	2008-09-03 10:49:37	3	74	240	4102	7665	1
+307	CL0307	FUSC		Fusaric acid resistance protein-like superfamily	Bateman A	anon	Members of this clan are likely to be integral membrane bound transporters.	2008-09-05 13:12:16	2008-09-05 14:12:16	3	0	73	3485	13824	1
+308	CL0308	DMSO_reductase	\N	Dimethyl sulfoxide reductase type II family	Coggill P	anon	This clan includes members that are type II dimethyl sulfoxide reductase families, all of which are also membrane anchor proteins belonging to the iron-sulfur molybdoenzyme (CISM) family [1].	2008-09-23 15:56:29	2008-09-23 16:56:29	3	8	25	1456	4376	1
+310	CL0310	DinB		DinB-like superfamily	Bateman A	anon	This superfamily are thought to be metalloenzymes.  They possess a four helical bundle core structure with a beta hairpin. Members of the superfamily have a predicted active site composed of three histidines that chelate Nickel or Zinc.  In some cases these histidines are replaced with Aspartate or Glutamate.  Mostly they form a dimeric structure. The dinB gene is one of the DNA-damage-induced genes and the corresponding protein, DinB, is the founding member of the clan. The protein contains a four-helix up-down-down-up bundle that has previously been described in the literature in three disparate proteins: the enzyme MDMPI (mycothiol-dependent maleylpyruvate isomerase), YfiT and TTHA0303, a member of a small DUF (domain of unknown function).  Most (but not all) clan members seem to have the ability to coordinate a metal ion using a conserved histidine-triad motif.  The proteins that share the fold exhibit four different quaternary structures: monomeric and three different dimeric forms [1].	2008-10-08 12:01:30	2008-10-08 13:01:30	3	36	73	2472	9715	1
+311	CL0311	SCP2	\N	SCP-2 sterol transfer superfamily	Bateman A	anon	This superfamily includes the SCP2 family as well as a domain from the mycothiol dependent maleylpyruvate isomerase.	2008-10-13 14:19:21	2008-10-13 15:19:21	3	29	62	2115	4976	1
+312	CL0312	HemS_ChuX	\N	Heme iron utilization protein-like superfamily	Bateman A	anon	This superfamily includes HemS and ChuX like protein families.	2008-10-22 16:49:13	2008-10-22 17:49:13	3	13	11	760	1473	1
+314	CL0314	PP-binding	\N	ACP-like superfamily	Bateman A	anon	\N	2008-11-19 12:30:53	2008-11-19 12:30:53	3	127	3226	5406	42314	1
+315	CL0315	Gx_transp		Gx transporter superfamily	Bateman A	anon	This superfamily includes a wide range of transporters that contain many conserved glycine residues in the presumed transmembrane regions.	2008-11-21 16:40:49	2008-11-21 16:40:49	3	4	132	4338	23854	1
+316	CL0316	Acyl_transf_3	\N	Membrane acyl transferase superfamily	Bateman A	anon	This superfamily includes a wide variety of integral membrane acyltransferase enzymes that often acylate sugars.	2008-11-24 13:14:42	2008-11-24 13:14:42	3	0	72	4090	17608	1
+317	CL0317	Multiheme_cytos		Multiheme cytochrome superfamily	Coggill P	anon	This family includes cytochromes that contain multiple CxxCH motifs.	2008-12-10 17:38:20	2008-12-10 17:38:20	3	247	280	1655	11292	1
+318	CL0318	Cytochrome-c		Cytochrome c superfamily	Coggill P	anon	This family includes proteins where a covalently-bound haem completes the core. The core is three helices in an open folded leaf formation. The members are monodomain cytochromes.	2008-12-12 14:30:33	2008-12-12 14:30:33	3	552	457	3452	28903	1
+319	CL0319	SHS2	Rob_SOUL;	SHS2 domain	Bateman A, Anantharaman V	anon	SHS2 is a novel domain with a simple fold containing a core of 3  strands, forming a curved sheet, and a single helix in a  strand-helix-strand-strand (SHS2) configuration [1]. SHS2 is found in the bacterial cell division ATPase FtsA, the archaeo-eukaryotic RNA  polymerase subunit Rpb7p, the GyrI superfamily, and the  uncharacterized MTH1598/Tm1083-like proteins [1]. The fold exists as single copy versions in FtsA (where it is inserted into the RNAseH fold), Rbp7p and Dodecin [1]. It is found as a diad in the GyrI  superfamily. In MTH1598/Tm1083-like proteins two copies of SHS2 are found with one inserted into another [1]. The single-copy versions in FtsA and Rbp7 mediate protein–protein interactions, while the one in  Dodecin is a small molecule binding domain. The GyrI also binds small molecule, while the MTH1598 is predicted to be enzymatic [1].	2008-12-12 19:39:43	2008-12-12 19:39:43	3	250	83	4602	13173	1
+320	CL0320	PepSY	\N	PepSY domain-like superfamily	Bateman A	anon	This family includes the PepSY domain as well as a family of uncharacterised proteins.	2008-12-15 13:39:08	2008-12-15 13:39:08	3	53	124	3218	10624	1
+321	CL0321	PLAT	\N	PLAT domain like superfamily	Bateman A	anon	This domain has an 8-stranded sandwich structure.	2008-12-15 14:40:00	2008-12-15 14:40:00	3	91	192	284	3462	1
+322	CL0322	RND_permease	\N	RND permease superfamily	Bateman A	anon	Different members of the RND superfamily have been shown to transport hydrophobic drugs, fatty acids, bile salts, organic solvents, heavy metals, autoinducers and lipooligosaccharides in bacteria [1].	2008-12-18 12:52:06	2008-12-18 12:52:06	3	91	154	4816	43065	1
+323	CL0323	Patatin	\N	Patatin/FabD/lysophospholipase-like superfamily	Bateman A	anon	This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes.	2008-12-18 16:43:32	2008-12-18 16:43:32	3	75	1413	5254	25679	1
+324	CL0324	Homing_endonuc	\N	Homing endonuclease-like superfamily	Bateman A	anon	This superfamily includes a variety of LAGLIDADG-like homing endonuclease like families.	2009-01-08 17:06:53	2009-01-08 17:06:53	3	109	309	2676	6450	1
+325	CL0325	Form_Glyc_dh	\N	Formate/glycerate dehydrogenase catalytic domain-like superfamily	Bateman A	anon	This superfamily includes the catalytic domain of a variety of dehydrogenase enzymes. The domain has a flavodoxin-like fold and contains an inserted Rossman fold NAD-binding domain.	2009-01-09 10:02:56	2009-01-09 10:02:56	3	370	93	4952	24576	1
+326	CL0326	Reo_sigma	\N	Virus attachment protein superfamily	Bateman A	anon	This superfamily includes virus attachment proteins that share a common beta sandwich domain.	2009-01-09 10:44:19	2009-01-09 10:44:19	3	291	20	282	678	1
+327	CL0327	Pilus	\N	Pilus subunit	Mistry J	anon	This is a clan contains bacterial pilus subunits and proteins involved in secretion.  Pili proteins enable the transfer of plasmid between bacteria. The families in this clan adopt an alpha helical structure which is packed against a beta sheet [2-3].	2009-01-12 11:15:14	2009-01-12 11:15:14	3	115	552	3218	21160	1
+328	CL0328	2heme_cytochrom		Transmembrane di-heme cytochrome superfamily	Bateman A	anon	This superfamily includes a variety of different heme binding cytochromes.	2009-05-08 19:48:23	\N	3	111	270	42880	138619	1
+329	CL0329	S5	\N	Ribosomal protein S5 domain 2-like superfamily	Bateman A	anon	This superfamily contains a wide range of families that possess a structure similar to the second domain of ribosomal S5 protein.	2009-05-08 19:52:37	\N	3	764	344	6126	79017	1
+330	CL0330	AVL9		Late secretory pathway transport machinery	Bateman A	anon	Members of this clan are involved in vesicle formation/trafficking.	2009-05-08 19:52:58	\N	3	2	129	304	2924	1
+331	CL0331	EpsM		General secretion pathway protein M	Coggill P	anon	These families are involved in the general secretory pathways of bacteria and are normally membrane-bound.	2009-05-08 19:53:19	\N	3	6	33	1882	7823	1
+332	CL0332	AcetylDC-like		Acetyl-decarboxylase like superfamily	Coggill P	anon	These families are double psi-beta barrel structures.	2009-05-08 19:53:39	\N	3	175	114	3736	19949	1
+333	CL0333	gCrystallin	gCrystallin-like;	Gamma-Crystallin-like superfamily	Coggill P	anon	This superfamily includes a number of mammalian crystallins as well as ancestral beta gamma-crystallin precursor structures.	2009-05-08 19:54:54	\N	3	107	65	320	3580	1
+334	CL0334	THBO-biosyn		Tetrahydrobiopterin biosynthesis-like enzyme superfamily	Coggill P	anon	The families in this clan bind purine or ptein in topologically similar sites between subunits.	2009-05-08 19:57:58	\N	3	423	52	4568	17543	1
+335	CL0335	FumRed-TM		Fumarate reductase respiratory complex transmembrane subunits	Coggill P	anon	This superfamily constitutes two distinct families: in one family the common fold is contained in a single-chain subunit, in the other it is formed by two chains.	2009-05-08 19:58:20	\N	3	154	20	3092	7355	1
+336	CL0336	FMN-binding		FMN-binding split barrel superfamily	Coggill P	anon	This includes those related to the ferredoxin reductase-like FAD-binding domain and those that are Pyridoxine 5'-phosphate oxidase (PNP)-like.	2009-05-08 19:58:45	\N	3	224	139	4634	22171	1
+337	CL0337	RF	\N	Release factor superfamily	Coggill P	anon	These families are peptide chain release factors.	2009-05-08 19:59:09	\N	3	19	24	4802	12227	1
+339	CL0339	PFL-like		PFL-like glycyl radical enzyme superfamily	Coggill P	anon	The N- and C-terminal halves of the structure have similar topologies but in some cases only one is represented by the members here, viz; the C-terminal domain of the R1 subunit of ribonucleotide reductase, and the N-terminal of PFL. The full-length structure is modelled by NRDD.	2009-05-08 19:59:52	\N	3	156	130	5379	23959	1
+340	CL0340	PTase-anion_tr		Phosphotransferase/anion transport protein superfamily	Coggill P	anon	The families here are the cytoplasmic regions of anion transporter proteins.	2009-05-08 20:00:18	\N	3	25	126	3482	19584	1
+341	CL0341	LDH_C	\N	LDH C-terminal domain-like superfamily	Bateman A	anon	This superfamily includes the C-terminal domain of lactate/malate dehydrogenase as well as the C-terminal domain of the glycosyl hydrolase 4 family.	2009-05-08 20:00:39	\N	3	454	19	7644	15125	1
+342	CL0342	TolB_N		TolB, N-terminal domain	Bateman A	anon	Members of this superfamily appear to behave like the N-terminal fold of the TolB transport-portal complex protein, which is beta-stranded.	2009-05-08 20:00:59	\N	3	23	67	2109	6978	1
+343	CL0343	MHC		MHC antigen-recognition domain	Coggill P	anon	This superfamily includes all the Class I-related antigen-recognition domain families.	2009-05-08 20:01:29	\N	3	1002	27	843	46029	1
+344	CL0344	4Fe-4S		4Fe-4S ferredoxins	Bateman A	anon	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	2009-05-08 20:01:52	\N	3	366	2266	6690	129668	1
+345	CL0345	Aerolisin_ETX		Aerolysin/ETX pore-forming domain superfamily	Coggill P	anon	This superfamily includes pore-forming venoms and toxins from bacteria, plants, insects and fish.	2009-05-08 20:02:15	\N	3	26	17	136	416	1
+346	CL0346	Ribo_L29	\N	Ribosomal protein L29, L29p, superfamily	Coggill P	anon	Superfamily includes Ribosomal protein L29 family and its corresponding mitochondrial ribosomal family, L47.	2009-05-08 20:02:37	\N	3	242	12	4897	5412	1
+347	CL0347	Tetraspannin		Tetraspannin-like	Mistry J, Finn RD	anon	This clan includes the tetraspanin family which contains four transmembrane regions.  The CD20 family also has four transmembrane regions, but its members are not considered true tetraspanins as they lack nearly all of the key functional tetraspanin residues [1].	2009-05-08 20:04:53	\N	3	8	50	746	6471	1
+348	CL0348	Phage_tail		Phage virion morphogenesis superfamily	Finn RD, Coggill P	anon	Families involved in joining the tail to the head of the  phage as well as those completing the head are included herein.   	2009-05-08 20:05:12	\N	3	0	8	1841	2993	1
+349	CL0349	DprA		MoCo carrier protein-like superfamily 	Bateman A	anon	Known family members of this superfamily are required for natural chromosomal and plasmid transformation. DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [1]. Superfamily includes lysine_decarboxylases.	2009-05-08 20:05:29	\N	3	59	53	4587	10964	1
+350	CL0350	PRC-barrel	\N	PRC-barrel like superfamily	Finn RD, Coggill P	anon	The PRC-barrel is an all beta barrel domain found in the photosynthetic reaction centre subunit H of the purple bacteria [1]. 	2009-05-08 20:05:48	\N	3	122	34	4098	7238	1
+351	CL0351	CHCH		Coiled-coil helix coiled-coil helix superfamily	Bateman A	anon	The conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain) superfamily members include NADH-ubiquinone oxidoreductases, some cytochrome oxidases and yeast mitochondrial ribosomal proteins. Within each helix of the CHCH domain there are two cysteines present in a C-X9-C motif.	2009-05-08 20:06:07	\N	3	58	39	353	2801	1
+352	CL0352	EsxAB		WXG100-A/WXG100-B dimer	Finn RD	anon	The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (PF06013), such as ESAT-10 (6 kDa early secreted antigenic target) and CFP-10 (10 kDa culture filtrate protein) in Mycobacterium tuberculosis or EsxA (ESAT-6-like extracellularly secreted protein A) and EsxB in Staphylococcus aureus. These two proteins, generally encoded in the same gene cluster, form a 1:1 heterodimeric complex. These proteins are virulence factors involved in host-pathogen interaction [1], as demonstrated in Mycobacterium tuberculosis, Staphylococcus aureus or Bacillus anthracis. The Wss is encoded in many other Gram-positive (monoderm) bacteria. This superfamily contains a number of DUFs which are closely related and may or may not represent the same family of proteins.	2009-05-08 20:06:25	\N	3	34	135	901	12295	1
+353	CL0353	TIMP-like	\N	TIMP-like superfamily	Bateman A	anon	This superfamily consists of the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I procollagen C-proteinase enhancer proteins, as well as the homologous N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs).	2009-05-08 20:06:43	\N	3	69	60	208	1675	1
+354	CL0354	bBprotInhib	\N	beta-Barrel protease inhibitors	Coggill P	anon	Superfamily consists of both metalloprotease- inhibitors and staphostatins.	2009-05-08 20:07:02	\N	2	12	6	424	573	1
+355	CL0355	CheC-like		CheC-like superfamily	Bateman A, Tuff TJ	anon	The chemotactic response regulator superfamily are CheY-P phosphatases. Their structure is two intertwined alpha-beta-(X)-beta(2) motifs. This superfamily comprises two classes of proteins each shown to interact with the chemotaxis response regulator CheY: the FliM switch proteins and the CheC-type phosphatases [1]. FliM is a component of the flagellar switch found across the bacteria and is responsible for binding CheY-P and changing the rotational direction of the flagella. The N-terminal domain is CheC-like and the C-terminal shares the SpoA domain with FliN and FliY. The CheC family is broadly broken down into three phosphatase subfamilies: CheC, CheX, and FliY. All three have an active site consensus sequence of D/S-X(3)-E-X(2)-N-X(22)-P.	2009-05-08 20:07:19	\N	3	20	27	2027	5059	1
+356	CL0356	AMP_N-like		Creatinase/prolidase N-terminal domain superfamily	Coggill P	anon	Bacterial amino-peptidases and creatinases, where the fold is a ribonuclease H-like motif, are grouped in this superfamily.	2009-05-08 20:07:37	\N	3	91	34	4808	10134	1
+357	CL0357	SMAD-FHA		SMAD/FHA domain superfamily	Bateman A	anon	Superfamily members carry a few short helices inserted in loops within the 11 strands in 2 sheets (greek-key) of the parent fold.	2009-05-08 20:07:54	\N	3	135	399	2102	12462	1
+359	CL0359	Intron-mat_II	\N	Type II intron maturase-like superfamily	Bateman A	anon	Superfamily includes a variety of transcription factors that bind intron RNA during reverse transcription and splicing.	2009-05-08 20:08:30	\N	3	14	51	26168	39344	1
+360	CL0360	MTH1187-YkoF		MTH1187/YkoF-like superfamily	Coggill P	anon	Putative cell-wall biogenesis proteins and HMP-binding proteins, all with the same Ferredoxin fold, are included in this superfamily.	2009-05-08 20:08:47	\N	3	35	7	1666	2146	1
+361	CL0361	C2H2-zf		Classical C2H2 and C2HC zinc fingers	Coggill P	anon	Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.	2009-05-08 20:09:05	\N	3	241	8637	2337	328673	1
+362	CL0362	RAMPS-Cas5-like		CRISPR-associated (Cas) Repair Associated Mysterious Proteins	Bateman A, Coggill P	anon	This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats [1]. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation [2]. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers [3].	2009-05-08 20:09:23	\N	3	24	24	1529	4925	1
+363	CL0363	H-int		Hedgehog/intein (Hint) superfamily	Bateman A	anon	This superfamily includes Hedgehog C-terminal (Hog) autoprocessing domain and Intein (protein splicing domain) families.	2009-05-08 20:09:41	\N	3	29	477	1142	3298	1
+364	CL0364	Leu-IlvD	\N	LeuD/IlvD-like	Bateman A	anon	Superfamily includes LeuD-like, IlvD/EDD C-terminal domain-like, and AF0055-like families.	2009-05-08 20:09:58	\N	3	36	36	4411	10971	1
+365	CL0365	MurF-HprK_N		MurF and HprK N-domain-like superfamily	Bateman A	anon	This includes both the MurE/MurF-ligases N-terminal domain and HPr kinase/phosphatase HprK N-terminal domain superfamilies.	2009-05-08 20:10:16	\N	3	14	40	3206	4809	1
+366	CL0366	JAB	Mov34-like;	JAB-like superfamily	Bateman A, Iyer LM, Zhang D, Aravind L	anon	This superfamily includes a number of proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits, regulators of transcription factors and ubiquitination-assisting protein families. In eukaryotes and in prokaryotic cognates of the ubiquitin-based  modification pathway, they function as ubiquitin isopeptidases/ deubiquitinases. JAB domains are also found in diverse metabolic pathways in prokaryotes such as siderophore and cysteine   biosynthesis. Other distinct versions of the JAB domain,  such as RadC are predicted to function as nucleases. Structurally, the  JAB domain is  related to the nucleotide deaminase and binds a Zinc ion in a similar structural location.	2009-05-08 20:10:33	\N	3	35	121	4285	10806	1
+367	CL0367	CI-2		CI-2 family of serine protease inhibitors	Bateman A	anon	This superfamily includes a range of universally found subtilases, that are serine proteases.	2009-05-08 20:10:50	\N	3	54	6	411	761	1
+368	CL0368	PhosC-NucP1	\N	Phospholipase C/P1 nuclease superfamily	Coggill P	anon	This superfamily includes the Phospholipase C and P1-nuclease families.	2009-05-08 20:11:07	\N	3	26	29	2543	5327	1
+369	CL0369	GHD		Glycosyl hydrolase domain superfamily	Bateman A	anon	This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.	2009-05-08 20:11:24	\N	3	345	276	4003	18678	1
+370	CL0370	Uteroglobin		Uteroglobin-like superfamily	Coggill P	anon	Members of this superfamily are disulfide-linked dimers of two identical chains, with 4 helices in each. They constitute important new cat, rat and rabbit allergens that are contributing to asthma world-wide.	2009-05-08 20:11:41	\N	3	12	2	47	309	1
+371	CL0371	Inovirus-Coat	\N	Inovirus (filamentous phage) major coat protein	Coggill P	anon	Superfamily contains a number of filamentous phage coat-protein families.	2009-05-08 20:11:58	\N	3	29	3	67	82	1
+372	CL0372	Hy-ly_N	\N	Hyaluronate lyase-like catalytic, N-terminal domain	Bateman A	anon	This contains virus envelope protein, Chondroitin AC lyase and hyaluronate lyase families.	2009-05-08 20:12:16	\N	3	44	53	774	1055	1
+373	CL0373	Phage-coat		Phage coat superfamily	Coggill P	anon	A number of different phage coat-proteins are collected together in this superfamily.	2009-05-08 20:12:33	\N	3	76	25	2757	4895	1
+374	CL0374	PEP-carboxyk	\N	PEP carboxykinase-like superfamily	Bateman A	anon	This includes the PEP carboxykinase C-terminal domain and HPr kinase HprK C-terminal domain families.	2009-05-08 20:12:50	\N	3	100	16	5373	7630	1
+375	CL0375	Transporter		Transporter superfamily	Bateman A	anon	The members of this superfamily are probably all transporter protein domains.	2009-05-08 20:13:08	\N	3	0	42	409	5210	1
+376	CL0376	Oxa1		Cytochrome oxidase biogenesis family	Bateman A	anon	The cytochrome oxidase biogenesis families are membrane transporters akin to the E coli protein YidC. For those proteins whose N-termini must reside in the intermembrane space, export is mediated by the Oxa1p export machinery, machinery that depends upon the membrane potential. Qxa1p homologues are found in all living organisms. TCDB:2.A.9.	2009-05-08 20:13:27	\N	3	0	30	4817	6863	1
+377	CL0377	FAH	\N	Fumarylacetoacetate hydrolase, C-terminal domain, superfamily	Bateman A	anon	Superfamily contains fumarylacetoacetate hydrolase and related enzymes,	2009-05-08 20:13:45	\N	3	104	39	3513	10941	1
+378	CL0378	ANL	Ac-CoA-synth;	ANL superfamily	Bateman A	anon	This superfamily consists of enzymes including luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely-related synthetases as well as a plant auxin-responsive promoter family.  The name ANL derives from from three of the subfamilies - Acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes [1].  Members of this superfamily catalyse the initial adenylation of a carboxylate to form an acyl-AMP intermediate, followed by a second partial reaction, most commonly the formation of a thioester [1].	2009-05-08 20:14:02	\N	3	149	2269	6257	68785	1
+379	CL0379	PgaPase	\N	Pyroglutamate aminopeptidase superfamily	Bateman A	anon	This is a collection of pyrrolidone carboxyl peptidase or pyroglutamate aminopeptidase families from bacteria and archaea.	2009-05-08 20:14:20	\N	3	60	16	1654	2070	1
+380	CL0380	IDO-like		Indolic compounds 2,3-dioxygenase-like superfamily	Bateman A	anon	Superfamily contains bacterial tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase-like families.	2009-05-08 20:14:37	\N	3	60	18	837	1644	1
+381	CL0381	Metallo-HOrase	\N	Metallo-hydrolase/oxidoreductase superfamily	Bateman A	anon	This superfamily of enzymes including beta-lactamases, thiolesterases, members of the glyoxalase II family that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid all bind two ions of zinc. An additional family of competence proteins essential for natural transformation do not appear to bind zinc, and might be a transporter involved in DNA uptake.	2009-05-08 20:14:54	\N	3	403	305	5380	50665	1
+382	CL0382	DNA-mend	\N	DNA breaking-rejoining enzyme superfamily	Bateman A	anon	This is a superfamily of DNA recombinases, topoisomerases and integrases.	2009-05-08 20:15:13	\N	3	116	209	6017	46990	1
+383	CL0383	PheT-TilS		Phenylalanine- and lysidine-tRNA synthetase domain superfamily	Coggill P	anon	Families here are thought to contain a putative tRNA-binding structural motif. The families are the C-terminal domains of tRNA-Ile-lysidine and the phenylalanine-tRNA synthetases.	2009-05-08 20:15:30	\N	3	31	54	4735	8465	1
+384	CL0384	PLC		PLC-like phosphodiesterases	Coggill P	anon	Superfamily consists of Glycerophosphoryl diester phosphodiesterase and phosphatidylinositol-specific phospholipase C families.	2009-05-08 20:15:48	\N	3	108	279	4173	15000	1
+385	CL0385	Hydrophilin	\N	Hydrophilin-like superfamily	Coggill P	anon	This superfamily includes plant and bacterial hydrophilin families.	2009-05-08 20:16:05	\N	3	0	17	752	2456	1
+386	CL0386	Ant-toxin_C	\N	Superantigen toxins, C-terminal domain superfamily	Coggill P	anon	Superfamily contains bacterial super-antigen toxins and the MAP family.	2009-05-08 20:16:23	\N	3	216	9	194	4767	1
+387	CL0387	DHFred	\N	Dihydrofolate reductase-like	Coggill P	anon	Superfamily contains the dihydrofolate reductases and the RibD C-terminal domain-like including HTP reductase families.	2009-05-08 20:16:40	\N	3	474	41	4883	12238	1
+388	CL0388	FadR-C	\N	Fatty acid responsive transcription factor FadR, C-terminal domain	Coggill P	anon	Superfamily includes C-terminal domain ligand-binding GntR families and families of fatty acid responsive transcription factors. This C-terminal domain, an antiparallel array of six alpha helices, forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain - a separate, DNA-binding winged-helix, domain.	2009-05-08 20:16:57	\N	3	24	47	3168	21611	1
+389	CL0389	TRAF	\N	TRAF domain-like superfamily	Coggill P	anon	Superfamily has a circularly permuted immunoglobulin-fold topology with extra an extra beta-strand. Families include the Math and the SIAH, or Seven in absentia, members.	2009-05-08 20:17:16	\N	3	106	201	1094	6315	1
+390	CL0390	zf-FYVE-PHD		FYVE/PHD zinc finger superfamily	Coggill P	anon	Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.	2009-05-08 20:17:33	\N	3	184	1096	1231	20485	1
+391	CL0391	CAP_C-like		Adenylate cyclase associated (CAP) C terminal like 	Mistry J	anon	Families in this clan adopt a beta super helix structure [1-2].  The clan includes the C terminal domain of adenylate cyclase which binds binds actin [1].	2009-05-08 20:17:50	\N	3	14	29	324	1064	1
+392	CL0392	Chaperone-J	\N	Chaperone J-domain superfamily	Coggill P	anon	The J-domain is found in a number of stress-response proteins.  It is found at the N-terminal of Hsc20, DnaJ-chaperone in E. coli,  and viral large T-antigen proteins; it is also in Hsc40, mammalian  auxilin and in both animal and plant DnaJ proteins. It is also  found in degenerate form in Pam16 proteins.	2009-05-08 20:18:07	\N	3	72	636	5592	28318	1
+393	CL0393	FucI-AraA_C	\N	FucI/AraA C-terminal domain-like [50443] 	Coggill P	anon	The enzymes in this superfamily function as a hexamer, which is the largest structurally known ketol isomerase, that has no  sequence or structural similarity to other ketol isomerases.	2009-05-08 20:18:26	\N	3	24	7	1558	2470	1
+394	CL0394	DsrEFH-like	\N	DsrEFH-like superfamily	Bateman A	anon	This is a superfamily of small proteins from phototrophic sulfur bacteria that are involved in oxidisation of  intracellular sulfur.	2009-05-08 20:18:45	\N	3	54	21	2423	6201	1
+395	CL0395	Tubby_C		Tubby C-terminal domain-like 	Bateman A	anon	This superfamily contains the scramblase protein family, the Tub family and the DUF567, a family of plant and bacterial proteins of hitherto unknown function. All members are membrane-tethered transcription factors.	2009-05-08 20:19:04	\N	3	9	44	886	2617	1
+396	CL0396	Marvel-like		MARVEL domain containing superfamily	Bateman A	anon	The MAL and related proteins for vesicle trafficking and membrane link (MARVEL) domain is a module with a four transmembrane-helix architecture that has been identified in proteins of the myelin and lymphocyte (MAL), physins, gyrins and occludin families.	2009-05-08 20:19:22	\N	3	0	28	346	3075	1
+397	CL0397	TusA-like	SirA-like;	TusA-like superfamily	Bateman A	anon	Member families include sulfurtransferase TusA.	2009-05-08 20:19:39	\N	3	8	61	3075	6124	1
+398	CL0398	RMMBL_DRMBL	\N	RNA/DNA-metabolising metallo-beta-lactamase motif	Mistry J	anon	This clan contains the fifth motif found in RNA and DNA metabolising metallo-beta-lactamases.  The fifth motif appears to be specific to function [1].	2009-05-08 20:19:56	\N	3	52	66	3672	6801	1
+399	CL0399	Asp-glut_race		Aspartate/glutamate racemase superfamily	Bateman A	anon	Superfamily contains aspartate racemase, glutamate racemase, hydantoin racemase and arylmalonate decarboxylase families from fungi, plants, bacteria and archaeal species.	2009-05-08 20:20:14	\N	3	108	17	4346	8931	1
+400	CL0400	GG-leader	\N	Double-Glycine leader-peptide cleavage motif	Coggill P	anon	This is a collection of short bacterial families that  carry a distinctive GG-cleavage motif. Conservation C-terminal to the GG-motif is not apparent. However, the families are  all interconnected with critical virulence attributes of one  kind or another.	2009-05-08 20:20:32	\N	3	5	10	475	1960	1
+401	CL0401	AsmA-like		AsmA-like OmpF regulator protein superfamily 	Bateman A	anon	Families in this collection are AsmA-like. Mutations in the AsmA gene restore the assembly of OmpF, a trimeric outer membrane porin from E coli and related bacteria necessary for the cytotoxic action of group-A colicins.	2009-05-08 20:20:49	\N	3	0	60	2432	11866	1
+402	CL0402	Cdc48_2-like		Cdc48 domain 2-like	Coggill P	anon	Superfamily contains C-terminal domains of N-ethylmaleimide sensitive fusion proteins, VCP-like ATPases, membrane fusion ATPase p97 domain 2, peroxisome biogenesis factor 1 (PEX-1), domain 2, and ubiquitin fusion degradation protein UFD1 families.	2009-05-08 20:21:06	\N	3	52	46	547	1899	1
+403	CL0403	ADC-like	\N	Acetoacetate decarboxylase-like	Finn RD	anon	Superfamily contains the acetoacetate decarboxylase enzyme family EC:4.1.1.4, and a family of uncharacterized proteins from bacteria.	2009-05-08 20:21:23	\N	3	20	14	682	968	1
+404	CL0404	BPD_transp_1	BPD_transp_1-like;	BPD transporter like	Mistry J, Finn RD	anon	This clan contains families that are involved in transport of molecules across membranes.  It includes the bacterial binding protein-dependent transport system inner membrane component, Pfam:PF00528, which is ATP dependent system involved in transport of a range of substrates [1-2].	2009-05-08 20:21:41	\N	3	36	162	5100	199771	1
+405	CL0405	DNA_b-psBarrel	DNA-bdg_psBarrel;	DNA-binding pseudo-barrel domain	Finn RD	anon	Superfamily consists of type II restriction endonuclease effector (N-term) domain and plant B3 DNA binding domain families.	2009-05-08 20:21:58	\N	3	5	51	174	2348	1
+406	CL0406	YjbJ-CsbD-like		YjbJ-CsbD-like superfamily	Finn RD	anon	CsbD is a bacterial general stress response protein. It's expression is mediated by sigma-B, an alternative sigma factor [1]. The role of CsbD in stress response is unclear. YjbJ is a hypothetical protein with a similar structure.	2009-05-08 20:22:16	\N	3	2	5	2526	5640	1
+407	CL0407	TBP-like		TATA-binding protein like	Mistry J, Finn RD	anon	TBP is a transcription factor whose DNA binding fold is composed of a curved antiparallel beta-sheet [1].  This fold is also found in the N terminal region of DNA repair glycosylases.  The N terminal domain of DNA glycosylase has only a single copy of the fold, whereas TBP contains a duplication of this fold [2-3].	2009-05-08 20:22:35	\N	3	138	32	2007	3848	1
+408	CL0408	PUP	\N	Purine and uridine phosphorylase superfamily	Bateman A	anon	superfamily contains a number of purine nucleoside phosphorylase, uridine nucleoside phosphorylase, and various nucleosidase families of proteins.	2009-05-08 20:22:53	\N	3	825	229	4830	16130	1
+409	CL0409	GAP	\N	GTPase activation domain superfamily	Finn RD	anon	Superfamily contains BCR-homology GTPase activation domain (BH-domain) and p120GAP domain-like, including the GAP related domain of neurofibromin, families.	2009-05-08 20:23:11	\N	3	42	410	365	9451	1
+410	CL0410	LEF-8-like		LEF-8 like region of RNA polymerase Rpb2	Mistry J, Finn RD	anon	Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to domain 6 of the second largest subunit of prokaryotic DNA-directed  RNA polymerase[1].	2009-05-08 20:23:28	\N	3	138	141	12554	17032	1
+411	CL0411	Vir		Antigenic variants from Plasmodium cell-surface	Finn RD	anon	Several families of paralogous proteins are included in this superfamily, largely from Plasmodium species. The genome expresses great numbers of them, and they vary subtly from each other.	2009-05-08 20:23:45	\N	3	0	7	9	1914	1
+412	CL0412	Frag1-like	\N	Frag1 like	Mistry J, Finn RD	anon	This clan contains the Frag1/DRA</Sfk1 Pfam family (Pfam:PF10277) and related families.	2009-05-08 20:24:02	\N	3	0	22	963	1905	1
+413	CL0413	Toprim-like		Toprim domain	Finn RD	anon	This is families that have a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1].	2009-05-08 20:24:21	\N	3	91	322	8438	38368	1
+414	CL0414	TerB	AB-resistance;	Tellurits and antibiotic resistance superfamily	Finn RD	anon	A number of families which show resistance to antibiotics or tellurite are included here.	2012-09-28 17:52:30	\N	3	5	36	1833	3980	1
+416	CL0416	Anoctamin-like	\N	Transmembrane protein families of the Anoctamin type	Finn RD, Coggill P	anon	The families are transmembrane families, where some of the members have sodium tolerance activity.	2009-05-08 20:25:15	\N	3	0	98	322	3409	1
+417	CL0417	BIR-like	\N	BIR-like domains	Mistry J, Finn RD	anon	Clan of domains all involved in binding nucleic acid and sharing the sequence motif C3HC.	2009-05-08 20:25:32	\N	3	187	45	401	2356	1
+418	CL0418	GIY-YIG	\N	GIY-YIG endonuclease superfamily	Finn RD, Coggill P	anon	Based on the analysis of genomic distribution, patterns of domain fusions and phylogenetic considerations for individual families, an evolutionary scenario is proposed that explains the emergence and development of the major branches of the GIY-YIG superfamily that links the Slx-type with the UvrC-like endonucleases. Most families appear to target DNA. The GIY-YIG domain has been quite successful in forming monomeric nucleases that utilise additional domains to recognise its DNA targets; this collection of domains can range from extremely simple DNA-binding elements (as in the case of I-TevI) to modules with independent enzymatic activities (as in the case of UvrC or the Penelope elements) [1].	2009-05-08 20:25:49	\N	3	20	115	5010	11825	1
+419	CL0419	T3SS-Chaperone	\N	Type III secretion system types a and b chaperone	Finn RD, Coggill P	anon	Type III secretion systems of the two forms, a - translocation-associated, and b - bacterial flagellum, share homology between comparable parts. This superfamily includes the chaperone proteins FliJ and HrpB7.	2009-05-08 20:26:06	\N	3	1	5	1738	1982	1
+420	CL0420	GlpM-like	\N	Bacterial membrane GlpM-like group	Finn RD, Coggill P	anon	This is a group of membrane proteins of the GlpM type.	2009-05-08 20:26:23	\N	3	0	3	964	1206	1
+421	CL0421	LppaM	\N	Lipo-protein attachment motif superfamily	Bateman A	anon	Superfamily consists of those protein families wherein the lipo-protein attachmnet motif, usually at the N-terminus, is found. regions of sequence downstream of this motif may not be conserved between families in the clan.	2009-05-08 21:19:03	\N	3	0	25	1166	2588	1
+422	CL0422	Fibrinogen_C		Fibrinogen C-terminal domain-like	Finn RD	anon	This is a collection of families with C-terminal domains that are of similar structure.	2009-05-08 21:19:20	\N	3	239	308	1080	6291	1
+423	CL0423	AhpD-like	\N	AhpD-like superfamily	Bateman A	anon	Superfamily contains CMD-like, and Antioxidant defense protein AhpD families.	2009-05-08 21:19:37	\N	3	112	49	3494	9816	1
+424	CL0424	T3SS-hook		Type III secretion system-derived superfamily, hook-related	Coggill P	anon	There is homology between the proteins forming the flagellar system and those involved in translocation of effector proteins at host-infection.  Both systems, in Gram-negative bacteria, are Sec-independent but ATPase-dependent.  There are up to 9 proteins that are homologous between the two systems.  It is not clear, however, why HpaP proteins, which are essentially suppressants of HrpB2, an essential pathogenicity factor, should also be homologous to any of these families.	2009-05-08 21:19:55	\N	3	1	12	3179	4912	1
+425	CL0425	ComplexI-N	\N	NADH dehydrogenase I, subunit N	Bateman A	anon	This superfamily contains proteins from the families Oxidored_q1 and NADHdeh_related. The Oxidored_q1 family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane. Many members of the NADHdeh_related family are archaeal and bacterial, indicating the evolutionary origins of ComplexI.	2009-05-08 21:20:12	\N	3	6	58	35038	91907	1
+426	CL0426	HRDC-like	\N	HRDC-like superfamily	Coggill P	anon	Superfamily includes HRDC domain from helicases, RNA polymerase II subunit RBP4, RNase D C-terminal domains, and EXOSC10 HRDC domain-like families.	2009-05-08 21:20:30	\N	3	84	86	3700	6906	1
+428	CL0428	TolA-TonB-Cterm		TolA/TonB C-terminal	Mistry J, Finn RD	anon	This clan contains the TolA and TonB C terminal domains.  These domains adopt a structure containing anti-parallel beta sheets with some alpha helical regions. The TolA family contains an extra N-terminal helix over the common fold, and the TonB is an isolated domain that can form different segment-swapped dimers depending on the fragment length [1].	2009-05-08 21:28:43	\N	3	17	93	2250	7994	1
+429	CL0429	UcrQ-like	\N	UcrQ-like	Finn RD	anon	The families here include those that are the H and S chains of cytochrome c subunit B1.	2009-05-08 21:29:01	\N	3	51	6	247	299	1
+430	CL0430	CopD_like		Copper resistance protein D	Mistry J	anon	This clan contains families that are related to the CopD family of proteins.\	    CopD, together with CopC, performs copper uptake into the cytoplasm.	2009-05-08 21:29:20	\N	3	0	20	2640	4510	1
+431	CL0431	PF		Profilin-like superfamily	Bateman A	anon	The families here all show the Profilin-like fold, and represent both the Profilin (actin-binding protein) (55770) and the Roadblock/LC7 domain-type (103196) superfamilies.	2009-05-08 21:29:38	\N	3	97	27	918	3101	1
+433	CL0433	SPFH	\N	SPFH superfamily	Bateman A	anon	This superfamily includes the SPFH family as well as the shoulder domain from the Major Vault Protein [1].	2009-07-06 09:16:10	\N	3	46	70	4547	14789	1
+434	CL0434	Sialidase		Sialidase superfamily	Bateman A	agb	This superfamily includes sialidases enzymes.  Several viruses use sialic acid as a cell surface receptor for host invasion. These viruses then have cell surface neuraminidase enzymes to cleave sialic acid from cell surface proteins allowing them to leave the host cell after replication.  This superfamily are composed of six beta-sheets that form a six-fold beta-propeller structure. Many members of this superfamily contain BNR sequence motifs Pfam:PF02012.	2009-08-03 11:40:27	2009-08-03 12:40:27	3	387	191	30583	37487	1
+435	CL0435	NPR		Nitrogen permease regulator family	Coggill P	pcc	The several protein families of nitrogen permease regulators, that complex together and regulator TORC1 in response to amino acid starvation are likely to have arisen by a gene duplication event.	2009-08-24 12:51:07	2009-08-24 13:51:07	3	0	11	254	791	1
+436	CL0436	FliG		Flagellar motor switch family	Coggill P	pcc	This superfamily is characterised by a fragmented superhelix consisting of 3-4 helical motifs and connecting helices. Memebers include the direct flagellar motor as well as the MG2+ families.	2009-08-24 13:45:28	2009-08-24 14:45:28	3	22	37	3585	10762	1
+437	CL0437	EF-G_C		Transcription elongation factor G C-terminal	Coggill P	pcc	This superfamily is characterised by being an alpha-beta 2-Layer Sandwich. It is found in EF2 proteins from both prokaryotes and eukaryotes, as well as in some tetracycline resistance proteins, peptide chain release factors ], and in the C-terminal region of the bacterial hypothetical protein, YigZ.	2009-08-24 15:16:01	2009-08-24 16:16:01	3	77	100	5888	33570	1
+438	CL0438	TTHA10132-281		Transcriptional regulators of TTHA1013 andTTHA0281 type	Coggill P	pcc	These families are characterised by sharing a 2-layer, beta(3)-alpha-beta topology. Domains dimerise via the long C-terminal strand with the formation of a single beta-sheet.	2009-08-24 16:09:48	2009-08-24 17:09:48	3	12	22	1503	2871	1
+439	CL0439	NusG-like		NusG-like	Mistry J	jm14	Members of this clan are related to the NusG transcription termination factor.  The eukaryotic orthologue of NusG is Spt5 [1].	2009-08-25 13:27:05	2009-08-25 14:27:05	3	24	30	4806	6515	1
+441	CL0441	AlbA		RNA-DNA binding Alba-like superfamily	Coggill P	pcc	This is a family of DNA and RNA binding proteins found from archaea to humans.	2009-08-27 10:57:56	2009-08-27 11:57:56	3	32	9	406	878	1
+442	CL0442	Tubulin-like	Tubulin_C;	Tubulin, FtsZ and Misato and their C-termini, GTPase	Coggill P	pcc	This superfamily is characterised by being of alpha-beta two-layer sandwich structures.  A segmental duplication early on in the primate lineage has led to the creation of up to three tubulin-like domains in the higher primates. The most N-terminal one is the Misato domain, which probably represents the original domain [3].	2009-08-28 12:07:36	2009-08-28 13:07:36	3	172	73	11198	35977	1
+444	CL0444	YNI		YcfA-nrd-intein domain	Coggill P	pcc	This superfamily is characterised by a short approx. 55 residue fold that is found in domains associated with flagellum formation and a short region withiin the homing endonucleases.	2009-09-10 10:49:46	2009-09-10 11:49:46	3	3	8	2112	3558	1
+445	CL0445	SNARE-fusion		SNARE-fusion membrane complex superfamily	Coggill P	pcc	The SNARE-fusion complex families are characterised by being tetrameric coiled-coil structures.	2009-09-10 14:55:14	2009-09-10 15:55:14	3	106	90	533	8433	1
+446	CL0446	Bacteriocin_TLN		Translocation domain of colicin-like bacteriocins	Coggill P	pcc	A number of different bacterial species produce bacteriocins to kill competitor species, and the colicin class is a group of complex three-domain structures. The receptor-binding domain recognises and binds to specific cell surface receptors on the target cells; the N-terminal translocation domain interacts with cell membrane proteins to gain access to the cell interior; the C-terminal domain specifies a killing activity, such as pore formation or nuclease activity. This superfamily is a collection of the translocating domains.	2009-11-02 18:54:23	2009-11-02 18:54:23	2	20	31	181	342	1
+447	CL0447	Hypoth_1		DUF1304/DUF3784 clan	Bateman A	agb	This superfamily includes two related families of short uncharacterised proteins from bacteria.	2009-11-06 14:19:03	2009-11-06 14:19:03	2	0	9	1408	1614	1
+448	CL0448	Cargo_bd_muHD		Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor	Coggill P	pcc	Internalisation of diverse transmembrane cargos from the plasma membrane requires a similarly diverse array of specialized adaptors, this domain is the binding domain of these endocytioc adaptors. The muHD binds directly to the cytosolic tail of the Mid2 (for the transmembrane stress sensor protein Mid2) cargo protein and mediates Mid2 internalization [1]. These are all-beta proteins.	2009-11-10 17:50:06	2009-11-10 17:50:06	2	32	35	501	2637	1
+449	CL0449	G-PATCH		DExH-box splicing factor binding site	Coggill P	pcc	This superfamily is characterised by domains which are related to the G-patch domain in proteins with RNA-binding/splicing activity. This domain affects RNA-splicing by binding to a DExH-box splicing factor.	2009-11-12 13:38:49	2009-11-12 13:38:49	2	0	141	389	3724	1
+450	CL0450	FimbA		Fimbriae A and Mfa superfamily	Xu Q, Finn RD, Coggill P	pcc	To add the reference from ActaF when it is published, A conserved fold for fimbriae components revealed by the crystal structure of a putative fimbriae assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 Angstrom resolution.  This family includes the fimbrillin-A set of fimbrial proteins and the shorter Mfa1 fimbrial set and their asoociated anchor-proteins Mfa2.	2009-11-25 16:52:50	2009-11-25 16:52:50	2	11	10	96	707	1
+451	CL0451	FnI-like		von Willebrand Factor like superfamily	Coggill P	pcc	This superfamily is characterised by being disulfide-rich, all-beta with an extra C-terminal domain in the fibronectin-like, Fn1, members.	2009-12-18 14:27:48	2009-12-18 14:27:48	2	8	460	161	4895	1
+452	CL0452	Tropomyosin-lke		Tropomyosin-like superfamily	Coggill P	pcc		2009-12-18 15:27:21	2009-12-18 15:27:21	2	54	27	554	1620	1
+453	CL0453	Apoptosis-Inhib		Inhibitors of suppressors of apoptosis Bax/Bak 	Coggill P	pcc	This family includes members which are Bax inhibitors.	2009-12-23 16:41:04	2009-12-23 16:41:04	2	0	14	4078	6492	1
+454	CL0454	Protease_inhib		Protease inhibitor toxin superfamily	Coggill P	pcc	This superfamily includes several families of toxins which seem to act as protease inuibitors.	2010-01-05 09:18:17	2010-01-05 09:18:17	2	215	445	329	6504	1
+455	CL0455	MIM-OM_import		Mitochondrial membrane transporting or complex assembly	Coggill P	pcc	This superfamily is characterised by being mitochondrial membrane proteins with importing activities.	2010-01-07 14:15:14	2010-01-07 14:15:14	2	1	8	326	612	1
+456	CL0456	Golgi_traff		Shuttling between cyosol and Golgi, peripheral membrane family	Coggill P	pcc	This superfamily is characterised by comprising multiple-pass membrane proteins that are associated with various aspects of trafficking of molecules into and out of the Golgi apparatus.	2010-01-08 15:41:51	2010-01-08 15:41:51	2	0	13	303	639	1
+457	CL0457	4HB_MCP		Aspartate chemoreceptor, signal-transduction ligand-binding	Ulrich L, Coggill P	pcc	This superfamily is characterised by a four-helix bundle structure that forms a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.	2010-01-11 14:55:11	2010-01-11 14:55:11	2	16	242	1922	9476	1
+458	CL0458	IIaaRS-ABD		Class II aaRS Anticodon-binding domain-like	Coggill P	pcc	This superfamily is characterised by including the anticodon-binding domain of Class II aaRS and the Brix domain.	2010-02-01 17:01:44	2010-02-01 17:01:44	2	142	103	4984	18087	1
+459	CL0459	BRCT-like		BRCT like 	Coggill P	pcc	The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage.	2010-02-01 17:02:12	2010-02-01 17:02:12	2	112	343	4755	10126	1
+461	CL0461	Metallothionein		Metal-bound fold, usually iron, metallothionein superfamily	Coggill P	pcc	This superfamily contains related families of metallothioneins, prokaryotes and eukaryotes.	2010-02-03 17:36:45	2010-02-03 17:36:45	2	24	9	332	753	1
+462	CL0462	TPA-repeat		Transcription elongation factor C-terminal nonapeptide repeat	Coggill P	pcc	This superfamily includes several families of this nonapeptide repeat, that carries a characteristic TPA motif. The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II.	2010-02-04 11:33:22	2010-02-04 11:33:22	2	10	36	254	580	1
+464	CL0464	5_3_exonuc_C		5'-3'-exonuclease C-terminal sub-region	Coggill P	pcc	This superfamily includes C-terminal domains from a number of DNA-processing enzymes including T4 RNase H, 5' to 3' exonuclease domain of DNA polymerase Taq, T5 5'-exonuclease, Flap endonuclease-1 (Fen-1 nuclease), and other eukaryotic endonucleases.	2010-02-04 17:13:51	2010-02-04 17:13:51	2	38	66	5048	8326	1
+465	CL0465	Ank		Ankyrin repeat superfamily	Bateman A	agb	The ankyrin repeat is a short sequence region that is about 30-34 amino-acids in length. Multiple copies of the repeat composed of two beta strands and two alpha helices combine to form long arrays. In general these repeats are involved in protein-protein interactions. This superfamily also includes some families that are arrays of several repeats.	2010-02-18 14:19:32	2010-02-18 14:19:32	2	168	6571	3000	134027	1
+466	CL0466	PDZ-like		PDZ domain-like peptide-binding superfamily	Coggill P	pcc	This superfamily comprises families of PDZ domains, which are peptide binding sites.	2010-02-23 10:29:00	2010-02-23 10:29:00	2	615	901	4966	46701	1
+468	CL0468	Malectin-like		Malectin-like superfamily	Coggill P	pcc	This superfamily includes several families of Malectin-type domains.	2010-02-24 16:54:44	2010-02-24 16:54:44	2	3	227	339	1899	1
+469	CL0469	l-integrase_N		lambda integrase N-terminal domain	Coggill P	pcc	This superfamily is characterised by families having 4-5 helices in a bundle of two orthogonally packed alpha-hairpins that are involved in interactions with DNA and proteins.	2010-02-24 17:58:15	2010-02-24 17:58:15	2	29	85	4649	20176	1
+470	CL0470	UMP_1		Uncharacterised membrane protein superfamily (UMP1)	Bateman A	agb	This superfamily includes two related families of membrane proteins. One of these is known as DUF1212. As yet there is no known function for any of these proteins.	2010-02-25 14:21:20	2010-02-25 14:21:20	2	0	13	2781	7529	1
+471	CL0471	DUF362		DUF362-like superfamily	Bateman A	agb	This superfamily incldues two uncharacterised families: DUF362 and DUF2088. These families contain a number of potential conserved metal binding residues and may be metalloenzymes.	2010-03-01 12:56:12	2010-03-01 12:56:12	2	2	26	685	1641	1
+472	CL0472	Peptidase_U		Peptidase clan U	Bateman A	agb	This superfamily includes proteins classed as clan U by the MEROPS database. The proteins are membrane bound peptidases.  The clan also includes Pfam:PF10086 which is a related family of uncharacterised proteins.	2010-03-11 15:27:58	2010-03-11 15:27:58	2	0	61	3770	14791	1
+474	CL0474	SICA_like		SICA alpha/beta like extracellular domains	Finn RD	rdf	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of three domains (alpha, beta and C-terminal).  The two extracelullar domains, termed SICA alpha and beta, occur with varying copy number.  The alpha domain, although it appears to be related to the beta domain, contains few cysteine residues and is found between 1 and 2 times, compared with the beta domain that occurs between 1 and 10 times (when present) [1].	2010-03-17 15:36:20	2010-03-17 15:36:20	2	0	38	2	575	1
+475	CL0475	Cyclophil-like		Cyclophilin-like superfamily	Coggill P	pcc	This superfamily is characterised by being the core, closed, beta barrel of cyclophilin with complex topology, with some family members lacking the N-terminal strand of cyclophilin but retaining a closed barrel.	2010-03-22 18:14:27	2010-03-22 18:14:27	2	310	183	4947	18056	1
+476	CL0476	tRNA-IECD_N		tRNA-intron endonuclease catalytic domain-like N-term	Coggill P	pcc	This superfamily contains families of the N-termini of tRNA-splicing endonucleases.	2010-04-13 08:59:45	2010-04-13 09:59:45	2	33	16	391	617	1
+477	CL0477	TRD		DNA methylase specificity domain	Bateman A	agb	This superfamily includes domains that are found associated with restriction modification methylase enzymes. These domains are involved in defining the DNA substrate specificity.	2010-05-04 15:55:02	2010-05-04 16:55:02	2	29	59	3119	12266	1
+478	CL0478	ATPase_I_AtpR	F_N_ATPase_a;	F-type and N-type ATPase, I/AtpR subunit 	Galperin M, Finn RD	rdf	These two subunits from the F-type and N-type ATPases have been demonstrated to from functionally distinct components of these two different ATPases[1].	2010-05-19 12:41:39	2010-05-19 13:41:39	2	0	2	1835	2145	1
+479	CL0479	PLD		Phospholipase D superfamily	Bateman A	pcc	This superfamily includes proteins that are related to Phospholiase D.	2010-06-17 09:09:37	2010-06-17 10:09:37	2	68	157	5070	25964	1
+480	CL0480	Ribosome_L1		Ribosomal L1 protein superfamily	Coggill P	pcc	This is a superfamily of Ribosomal L1 protein families.	2010-06-29 09:40:59	2010-06-29 10:40:59	2	95	18	4960	6004	1
+481	CL0481	HUH		His-hydrophobic-His tranposase Y1,Y2 superfamily	Coggill P	pcc	This superfamily consists of families of transposases that use tyrosine as nucleophiles and contain a conserved HUH motif where U is a non-conserved hydrophobic residue. Particular examples are the Y1 and Y2 transposases. Y1 transposases come from the IS608 group and the Y2 from the IS91 group. These transposases are nucleases involved in initiating rolling-circle plasmid replication, in initiating replication of certain single-strand (ss) DNA viruses (Rep proteins), and in initiation of conjugative plasmid transfer (relaxases). The IS91 transposase contains two of the three conserved protein sequence motifs identified in RCR proteins, a His-hydrophobic-His (HUH) motif required for metal ion binding, and a YxxxY motif containing two conserved catalytic tyrosine residues. The HUH motif participates in coordinating divalent metal ions essential for catalysis.  This clan is also known as the Transposase IS200-like whose members contain extra N-terminal hairpin and C-terminal helix, both or which are involved in dimerisation; there can be helix-swapping in the dimer.	2010-07-13 12:33:47	2010-07-13 13:33:47	2	40	49	2384	6860	1
+482	CL0482	Prolamin		Di-sulfide bond pairrings	Coggill P	pcc	This superfamily is characterised by families with only slightly differing disulfide-bonding patterning.	2010-07-21 12:41:48	2010-07-21 13:41:48	2	54	35	364	5909	1
+483	CL0483	PreATP-grasp		Probable substrate-binding preceding ATP-grasp domain	Coggill P	pcc	This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.	2010-07-21 12:47:06	2010-07-21 13:47:06	2	32	18	1652	2776	1
+484	CL0484	Peroxisome		Peroxisome-like domain	Coggill P	pcc	This superfamily combines peroxisome families and a family found at the C-terminus of metazoan phosphoribosyltransferases.	2010-07-21 12:49:56	2010-07-21 13:49:56	2	0	76	283	1175	1
+486	CL0486	Fer2		2Fe-2S iron-sulfur cluster binding domain	Bateman A	agb	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domani is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	2010-07-24 11:00:26	2010-07-24 12:00:26	2	362	461	5503	37176	1
+487	CL0487	FKBP		FKBP-like superfamily	Bateman A	agb	This superfamily includes the FKBP domain which catalyses the peptidyl-prolyl cis-trans isomerisation reaction. The superfamily also includes the C-terminal domain of GreA and the c-terminal dmoain of 3-mercaptopyruvate sulfurtransferase.	2010-07-25 11:45:24	2010-07-25 12:45:24	2	104	100	4781	19148	1
+488	CL0488	FixH-like		FixH-like	Coggill P	pcc	This is a superfamily of FixH-like proteins of unknown function.	2010-07-28 13:48:41	2010-07-28 14:48:41	2	0	16	1183	1566	1
+489	CL0489	AFP_III-like		Type III antifreeze and spore coat polysaccharide	Coggill P	pcc	This is a superfamily of antifreeze proteins, flagellar FlgA, pilus and spore coat polysaccharide families.	2010-07-29 13:32:26	2010-07-29 14:32:26	2	26	28	2940	6862	1
+490	CL0490	PepSY_TM-like		PepSY_TM-like	Coggill P	pcc	This is a superfamily of PepSY-transmembrane-like domain families.	2010-08-04 15:51:29	2010-08-04 16:51:29	2	0	70	1771	6672	1
+491	CL0491	LYR-like		Complex1_LYR-like superfamily	Coggill P	pcc	This is a superfamily of sequences with the characteristic LYR, or similar, motif. In some yeasts this family plays a role in Fe-S cluster biogenesis in mitochondria.	2010-08-19 16:20:34	2010-08-19 17:20:34	2	0	33	323	2362	1
+492	CL0492	S4		S4 domain superfamily	Bateman A	agb	This superfamily includes diverse proteins related to the ribosomal S4 protein.	2010-08-27 15:46:09	2010-08-27 16:46:09	2	226	44	10099	38684	1
+493	CL0493	PTS_EIIC		Phosphotransferase system, EIIC superfamily	Bateman A	agb		2010-09-02 14:47:12	2010-09-02 15:47:12	2	4	39	2905	27857	1
+494	CL0494	DnaA_N		DNA-A N-terminal domain-like superfamily	Bateman A	agb	This superfamily includes the N-terminal domain from DnaA and the N-terminal domain from DNA polymerase III alpha subunit.	2010-09-17 12:39:03	2010-09-17 13:39:03	2	2	33	3617	4495	1
+496	CL0496	Tad-like		Flp pilus-biogenesis Tad-like superfamily	Coggill P	pcc	This is a superfamily of Tad-like protein families all involved in Flp pilus biogenesis.	2010-09-28 15:11:00	2010-09-28 16:11:00	2	0	22	1048	3415	1
+497	CL0497	GST_C		Glutathione S-transferase, C-terminal domain	Bateman A	agb	This clan represents the C-terminal domain of Glutathione S-transferase.	2010-10-04 10:28:59	2010-10-04 11:28:59	2	839	219	3208	23337	1
+498	CL0498	Nribosyltransf		N-(deoxy)ribosyltransferase-like superfamily	Bateman A	agb	This superfamily includes the N-deoxyribosyltransferase and ADP-ribosyl cyclase-like families as well as the family that includes the hypothetical protein PA1492 for which the structure is known. PA1942 has a very similar putative active site and is predicted by SCOP to have a deoxyribosyltransferase activity [1].	2010-10-07 15:46:04	2010-10-07 16:46:04	2	193	14	1181	1635	1
+499	CL0499	O-antige_ligase		O-antigen-ligase like superfamily	Coggill P	pcc	This superfamily is characterised by a group of bacterial proteins that are membrane proteins, and include O-antigen ligases and putative hydrogen carbonate transporters [1].	2010-10-07 17:04:39	2010-10-07 18:04:39	2	0	73	3419	7279	1
+500	CL0500	Glycine-zipper		Glycine-zipper TM superfamily	Coggill P	pcc	This superfamily is characterised by having long glycine-zipper motifs, characteristically GxxxGxxxG [1], often with several contiguous copies. The x following the G is frequently found to be an alanine. This sequence region can be found in both symmetric and non-symmetrical membrane structures, and is relatively common. The fact that such a large fraction of the relatively few known membrane channel structures use the glycine zipper suggests that the sequence motif plays a special role in forming these homo-oligomeric bundles [1].	2010-10-14 10:24:07	2010-10-14 11:24:07	2	0	44	2301	7226	1
+501	CL0501	Gram-pos_anchor		Cell wall anchoring	Coggill P	pcc	This superfamily is characterised by families involved in the various mechanisms by which listerial proteins are attached at the bacterial surface and their many functions, including peptidoglycan metabolism, protein processing, adhesion to host cells, and invasion of host tissues.	2010-10-26 16:08:05	2010-10-26 17:08:05	2	20	882	1222	13906	1
+502	CL0502	STAS		STAS domain superfamily	Bateman A	agb	This superfamily includes proteins that have a STAS domain.	2010-10-28 16:36:18	2010-10-28 17:36:18	2	44	161	3695	13648	1
+503	CL0503	SOR		Superoxide reductase-like superfamily	Bateman A	agb	According to SCOP this superfamily includes the superoxide reductase domain as well as the C-terminal domain of desulfoferrodoxin.	2010-11-08 17:40:12	2010-11-08 17:40:12	2	55	13	767	1038	1
+504	CL0504	Phage_barrel		Phage tail beta-barrel superfamily	Bateman A	agb	This superfamily consists of a variety of bacteriophage protein families. Structurally members of this family contain a beta barrel.	2010-11-22 16:23:10	2010-11-22 16:23:10	2	18	106	2048	9306	1
+505	CL0505	Pentapeptide		Pentapeptide repeat	Bateman A	agb	This clan includes proteins that form a four sided parallel beta helix. They are generally compoased of pentapeptide repeat motifs.	2010-11-26 10:06:54	2010-11-26 10:06:54	2	43	484	2438	18381	1
+506	CL0506	Succ_CoA_synth		Succinyl-CoA synthetase flavodoxin domain superfamily	Bateman A	agb	This superfamily includes the flavodoxin like domain of succinyl-CoA synthetase and other related enzymes.	2010-12-02 12:48:20	2010-12-02 12:48:20	2	70	59	3740	11176	1
+507	CL0507	Fungal_trans		Fungal specific transcription factor domain	Bateman A	agb	This putative domain is found in fungal transcription factors.	2010-12-06 17:47:20	2010-12-06 17:47:20	2	0	306	239	14641	1
+508	CL0508	YkuD		L,D-transpeptidase catalytic domain	Bateman A	agb	This superfamily incldues the L,D-transpeptidase catalytic domain.	2010-12-08 12:28:21	2010-12-08 12:28:21	2	8	84	3166	11690	1
+509	CL0509	RBP11-like		RBP11-like subunits of RNA polymerase	Coggill P	pcc	This superfamily is characterised by all members carrying RNA Polymerase alpha subunit, chain A, domain 2. The member families form homo- and hetero-dimers.	2010-12-09 14:07:20	2010-12-09 14:07:20	2	280	32	6187	8189	1
+511	CL0511	Retroviral_zf		Retrovirus zinc finger-like domains	Coggill P	pcc	This superfamily has zinc-finger domains from GAG proteins, HIV nucleocapsids, nucleocapsid proteins from mason-pfizer monkey virus, and from other nucleic-acid binding proteins. Sometimes the domains appears in duplicate.	2011-01-17 16:09:42	2011-01-17 16:09:42	2	46	796	752	52586	1
+512	CL0512	CRAL_TRIO		CRAL-TRIO domain superfamily	Bateman A	agb	This superfamily includes the CRAL-TRIO domain.	2011-01-21 18:16:17	2011-01-21 18:16:17	2	28	141	377	5546	1
+513	CL0513	LCCL-domain		LCCL-domain like	Coggill P	pcc	This superfamily is characterised by an unusual fold exemplified in PDB:1jbi. Vertebrate members are the cysteine-rich secretory protein LCCL domain-containing proteins including Colchin. The fungal members are found to be necessary for histone de-acetylation.	2011-01-28 14:34:24	2011-01-28 14:34:24	2	1	51	235	1023	1
+515	CL0515	LTXXQ-like		LTXXQ-like superfamily	Coggill P	pcc	This is a superfamily of members all carrying the repeated LTxxQ paired sequence-motif region.	2011-02-10 14:04:19	2011-02-10 14:04:19	2	36	8	1376	2943	1
+516	CL0516	ISP-domain		Rieske-like iron-sulphur domain	Coggill P	pcc	This superfamily is characterised by Rieske Iron-sulfur families of the [2Fe-2S] type including NADH-nitrite reductase small subunit NirD proteins. This domain has an all-beta rubredoxin-like fold.	2011-02-14 16:52:53	2011-02-14 16:52:53	2	328	118	3882	14974	1
+517	CL0517	MBOAT-like		Membrane-bound O-acyltransferase,MBOAT,superfamily	Coggill P	pcc	This is a large superfamily of different enzymes. All biochemically characterised members of the superfamily encode enzymes that transfer organic acids, typically fatty acids, onto hydroxyl groups of membrane-embedded targets.	2011-02-16 11:16:11	2011-02-16 11:16:11	2	0	40	2323	5182	1
+520	CL0520	Keratin_assoc		Keratin_associated superfamily	Coggill P	pcc	Families in this clan are cysteine-rich and are from proteins associated with Keratin.	2011-03-09 11:23:29	2011-03-09 11:23:29	2	0	33	65	2969	1
+521	CL0521	GOLD-like		Sec14-like superfamily of golgi trafficking	Coggill P	pcc	This superfamily is characterised by proteins with a sandwich structure of 8 strands in 2 sheets as a jelly-roll.  The structure has similarity to the Nucleoplasmin-like/VP fold. The members are all involved in golgi trafficking.	2011-03-21 16:36:53	2011-03-21 16:36:53	2	5	40	359	2519	1
+522	CL0522	YbjQ-like		YbjQ-like superfamily	Coggill P	pcc	This superfamily is characterised by chains that form pentamers. Family structures are beta/alpha-propellers with additional short beta-strands that promote oligomeric assembly. Family members appear to be heavy-metal binding proteins.	2011-05-13 14:50:08	2011-05-13 15:50:08	2	25	7	1982	2593	1
+523	CL0523	GAG-polyprotein		LTR-copia-type polyprtien segments	Coggill P	pcc	This superfamily is characterised by family members that ar derived from retrotransposons of the copia-type.	2011-05-13 16:31:38	2011-05-13 17:31:38	2	0	851	262	10309	1
+524	CL0524	MPT63-MPB63		Antigen MPT63/MPB63 (immunoprotective extracellular	Coggill P	pcc	This superfamily is characterised by extracellular proteins with immuno-protectivce receptor domains on their surfaces resembling Ig domains. These are putative lipoproteins.	2011-05-23 13:54:12	2011-05-23 14:54:12	2	5	23	844	1193	1
+525	CL0525	pap2		Acid phosphatase/Vanadium-dependent haloperoxidase	Coggill P	pcc	The PAP2 superfamily is characterised by being mult-helical, with the core consisting of a 5-helical bundle. Normally the family will bind cofactor at the beginning of the third helix. The superfamily includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.	2011-06-02 14:59:14	2011-06-02 15:59:14	2	44	106	4454	15593	1
+526	CL0526	SUKH		SUKH superfamily	Zhang D, Iyer LM, Aravind L	la_psag	SUKH superfamily unites a diverse group of proteins including  Smi1/Knr4, PGs2, Fbxo3, Skip16, Syd, herpesviral US22, IRS1 and TRS1, and their bacterial homologs [1].	2011-07-18 20:15:40	2011-07-18 21:15:40	2	8	49	1725	4317	1
+527	CL0527	Sm-like		Sm (Small RNA binding protein domain)	Anantharaman V	la_psag	Conserved domain of core RNA-binding proteins of mRNA splicing and rRNA processing complexes, with a SH3-like Beta-barrel	2011-09-10 05:20:17	2011-09-10 06:20:17	2	515	85	2737	9033	1
+528	CL0528	DUF1214		DUF1214-like	Finn RD	rdf	Members of this clan usually appear in pairs on the same sequence. In cases where there is only a single example of the domain, there is often a second protein containing a single domain that is located sequentially along the chromosome. The crystal structure of pdb:2P3Y reveals that Pfam:PF06863 and Pfam:PF06742 come together to from a deep, positively charged pocket or cleft.  Structural comparisons reveal that this may this pocket that may bind some form of carbohydrate. Conserved residues are predominantly found on the surface of the positively charged cleft [Jayaraman et al. personal communication].	2011-09-23 21:21:03	2011-09-23 22:21:03	2	9	15	656	2556	1
+529	CL0529	FMN-dep-NRtase		FMN-dependent nitroreductase-like	Coggill P	pcc	This superfamily is involved in the reduction of nitrogen containing compounds. Members of this family utilise FMN as a cofactor and are often found to be homodimers. Possible characteristics include Oxygen-insensitive NAD(P)H nitroreductase (FMN-dependent nitroreductase) (Dihydropteridine reductase) and NADH dehydrogenase. A number of the proteins are described as oxidoreductases. They are primarily found in bacterial lineages though a number of eukaryotic homologues have been identified: Caenorhabditis elegans, Drosophila melanogaster, mouse and human. These protein are not found in photosynthetic eukaryotes; sequences containing this entry in photosynthetic organisms are possible false positives.	2011-11-17 15:49:14	2011-11-17 15:49:14	1	206	111	4539	16601	1
+530	CL0530	DNase_I-like		DNase I-like	Coggill P	pcc	This superfamily is characterised by members with an alpha-beta four-layer sandwich structure. It includes DNase I-like families of DNA-repair enzyme exonuclease III, DNA repair endonucleases, deoxyribonuclease I, endonuclease domain of retro-transposons. It also includes families of inositol polyphosphatases and shingomyelins-phosphodiesterases.	2011-11-29 11:19:36	2011-11-29 11:19:36	1	148	496	4823	22404	1
+531	CL0531	AMP-binding_C		AMP-binding enzyme C-terminal domain superfamily	Eberhardt R	re3	This superfamily contains domains found at the C-terminus of AMP-binding enzyme.	2011-12-02 13:00:41	2011-12-02 13:00:41	1	111	1767	5099	46854	1
+532	CL0532	LIG		Lipid-binding Ig-like superfamily	Bateman A	agb	This superfamily includes a number of lipid binding families that have a similar topology to the immunoglobulin fold. The family includes The ML domain Pfam:PF02221. It includes the uncharacterised family Pfam:PF06477.	2011-12-21 10:45:29	2011-12-21 10:45:29	1	68	32	336	2678	1
+533	CL0533	PRTase-like		PRPP synthetase-associated protein 1 	Coggill P	pcc	This superfamily of phosphoribosyl-transferases (PRTases) and phosphoribosyl-pyrophosphate synthetase-like protein families is characterised by a core fold of three layers, a/b/a with a mixed beta-sheet of six strands. In one of the families consists of two domains of this fold.	2012-01-09 11:27:00	2012-01-09 11:27:00	1	392	122	5229	42734	1
+534	CL0534	YjgF-like		YjgF-like superfamily	Coggill P	pcc	This superfamily is characterised by proteins that form trimers with three closely packed beta-sheets. Some member proteins are chorismate mutases, others are endoribonucleases active on single-stranded mRNA. It is the highly conserved YjgF/YER057c/UK114 protein superfamily. Homologues of this protein occur in eubacteria, archaea, and eukaryotes. Proteins are functionally diverse and are involved in a variety of enzymatic and non-enzymatic functions. The high sequence and structural similarity between members of this protein superfamily offer an example of minimalistic changes leading to functional diversification. This feature is best exemplified by the three close homologues of YjgF proteins in mammals (human, rat, and goat) with sequence identity better than 85%. These homologues perform different functions, including tumour antigen activity in the goat homologue, translation inhibition in the human and rat homologues (hp14.5 and rp14.5), endoribonuclease activity in rp14.5, calpain activation in the bovine homologue, molecular chaperone activity in DUK114, and involvement in the regulation of purine and removal of toxic metabolites in YjgF7, and involvement in isoleucine biosynthetic pathways (YjgF, YER057c, Ibm1). In addition, members of this protein family have also been shown to regulate mitochondrial maintenance (Ibm1) in yeast. Proteins from the YjgF family in plants are involved in photosynthesis and chromoplastogenesis (CHRD).	2012-01-18 11:20:47	2012-01-18 11:20:47	1	251	69	4391	13028	1
+535	CL0535	CBM		Carbohydrate-binding superfamily	Coggill P	pcc	This clan includes families of two different carbohydrate binding modules, chitin- and cellulase-binders.	2012-01-23 14:31:27	2012-01-23 14:31:27	1	41	221	1097	3033	1
+536	CL0536	HEXAPEP		Hexapeptide repeat superfamily	Coggill P	pcc	This superfamily is characterised by superhelical turns made up of three short strands duplicated many times; the sequence hexapeptide repeats correspond to individual strands. These hexapeptide repeat regions occur in a range of transferase enzymes.	2012-01-23 14:56:06	2012-01-23 14:56:06	1	380	348	5071	79539	1
+537	CL0537	CCCH_zf		CCCH-zinc finger	Coggill P	pcc	This superfamily is characterised by families of proteins with several Cys3His zinc-binding domains in tandem.	2012-01-26 16:19:39	2012-01-26 16:19:39	1	17	263	457	8803	1
+538	CL0538	DRMIP-like		MAPK-interacting Drmip-like superfamily	Coggill P	pcc	This superfamily contains members that are similar to the MAPK-interacting DRMIP-like family.	2012-02-01 16:26:27	2012-02-01 16:26:27	1	0	20	175	786	1
+539	CL0539	RNase_III		RNase III domain-like superfamily	Coggill P	pcc	This superfamily is characterised structurally by having a core of 5 helices where one of the helices is surrounded by the others.  Many members have the endonuclease catalytic domain.	2012-02-06 18:13:43	2012-02-06 18:13:43	1	62	100	4733	7980	1
+540	CL0540	GCP		Gamma-tubulin complex superfamily	Coggill P	pcc	This superfamily carries families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome.	2012-02-09 14:22:48	2012-02-09 14:22:48	1	1	23	316	1604	1
+541	CL0541	SH2-like		SH2, phosphotyrosine-recognition domain superfamily	Coggill P	pcc	This superfamily is characterised by proteins with the SH2-like fold. The proesence of this domain guides signal-transduction towards the phosphorylated tyrosine residues on its interacting protein-partner.	2012-02-21 16:19:05	2012-02-21 16:19:05	1	387	421	453	9393	1
+542	CL0542	RAS_GEF_N		Ras guanyl-nucleotide exchange factor activity N-term	Coggill P	pcc	This is the more N-terminal domain of the RAS-GEF superfamily.	2012-02-29 11:57:43	2012-02-29 11:57:43	1	14	157	277	2682	1
+543	CL0543	Viral_gly_cn_dm		Viral glycoprotein central and dimerisation domains	Eberhardt R	re3	Flavivirus and alpha virus glycoprotein E/E1 consists of three domains. A dimerisation domain, a central domain and an immunoglobulin-like domain. The dimerisation and central domains are intertwined [1-3].	2012-03-23 15:37:00	2012-03-23 15:37:00	1	93	37	200	12815	1
+544	CL0544	AcylCoA_ox_dh_N		Acyl-coenzyme A oxidase/dehydrogenase N-terminal	Eberhardt R	re3	Acyl-CoA dehydrogenases and acyl-coenzyme A oxidases consist of three domains. An N-terminal all alpha domain, a beta-barrel middle domain and a C-terminal catalytic domain [1-2].	2012-03-27 08:17:33	2012-03-27 09:17:33	1	223	112	3478	26792	1
+545	CL0545	APCOP-app_sub		Clathrin (AP) and COPI appendage platform  subdomain	Coggill P	pcc	This superfamily is characterised by subdomains from the clathrin and coatomer appendages. The superfamily possesses a single protein/protein interaction site that in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2 [1].	2012-04-18 13:17:34	2012-04-18 14:17:34	1	0	11	303	446	1
+546	CL0546	Hexosaminidase		beta-N-acetylhexosaminidase-like domain	Coggill P	pcc	This superfamily is characterised by a mixed beta sheet with connection over the free side of the sheet. The fold is like a zincin fold lacking the catalytic centre.	2012-04-30 14:53:24	2012-04-30 15:53:24	1	124	150	1212	3278	1
+547	CL0547	GF_recep_C-rich		Growth factor receptor Cys-rich	Eberhardt R	re3	The cysteine-rich regions of growth factor receptor tyrosine kinases consist of eight disulphide-linked modules [1].	2012-05-01 09:19:56	2012-05-01 10:19:56	1	49	88	140	2125	1
+548	CL0548	IHF-likeDNA-bdg		IHF-like DNA-binding protein supewrfamily	Coggill P	pcc	This superfamily is characterised by being a dimer of identical subunits of a core of four helices in a bundle, partly opened, capped with a beta-sheet. All members appear to be prokaryotic DNA-binding domains.	2012-05-01 16:00:04	2012-05-01 17:00:04	1	60	13	4459	12213	1
+549	CL0549	NicO_HupE_DsbD		NicO/HupE/DsdD superfamily	Eberhardt R	re3	This clan contains the nickel transpot family NicO [1-2] and the HupE/UreJ proteins, which may be involved in nickel binding. NicO and HupE contain a conserved GxxHxxxDH motif, which may bind to nickel.	2012-05-31 10:50:16	2012-05-31 11:50:16	1	0	55	3953	10451	1
+550	CL0550	SRCR		SRCR-like	Eberhardt R	re3		2012-07-11 13:20:22	2012-07-11 14:20:22	1	19	402	139	9451	1
+551	CL0551	BCLiA		Bcl-2 inhibitors of programmed cell death	Coggill P	pcc	This superfamily is characterised by families of proteins that inhibit apoptosis, They are regulated by all BH3-only proteins to promote apoptosis.	2012-08-31 14:55:14	2012-08-31 15:55:14	1	151	28	348	1402	1
+552	CL0552	Hect		Hect, E3 ligase catalytic domain	Coggill P	pcc	This superfamily is characterised by fmailies with E3-ligase catalytic acitvity.  The fold consists of two alpha+beta domains; where the N-terminal domain is an array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit.	2012-09-07 15:42:50	2012-09-07 16:42:50	1	23	249	342	4684	1
+553	CL0553	HBMR		Helical backbone metal receptor superfamily	Coggill P	pcc	This superfamily is characterised by a long alpha helical insertion in the interdomain linker in the Chelatase-like fold. Representative families include the periplasmic ferric siderophore binding proteins, the TroA-like nitrogenase iron-molybdenum proteins and the putative iron(III) transporter family, TM0189-like, or periplasmic-binding family.	2012-09-12 10:08:39	2012-09-12 11:08:39	1	190	51	4828	19772	1
diff -r 000000000000 -r 68a3648c7d91 pfam_search/f1
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/f1	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,504 @@
+
+1
+# pfam_scan.pl, run at Fri Jul 3 12:01:47 2015
+#
+# Copyright (c) 2009 Genome Research Ltd
+# Freely distributed under the GNU
+# General Public License
+#
+# Authors: Jaina Mistry (jaina@ebi.ac.uk),
+# Rob Finn (rdf@ebi.ac.uk)
+#
+# This is free software; you can redistribute it and/or modify it under
+# the terms of the GNU General Public License as published by the Free Software
+# Foundation; either version 2 of the License, or (at your option) any later version.
+# This program is distributed in the hope that it will be useful, but WITHOUT
+# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+# FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+# details.
+#
+# You should have received a copy of the GNU General Public License along with
+# this program. If not, see <http://www.gnu.org/licenses/>.
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+# query sequence file: /home/inmare/galaxy/database/files/000/dataset_578.dat
+# cpu number specified: 2
+# searching against: /home/inmare/galaxy/tools/pfamScan/hmm/Pfam-A.hmm, with cut off --cut_ga
+# resolve clan overlaps: on
+# predict active sites: off
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+#
+# <seq id> <alignment start> <alignment end> <envelope start> <envelope end> <hmm acc> <hmm name> <type> <hmm start> <hmm end> <hmm length> <bit score> <E-value> <significance> <clan>
+10FR_NODE_6#PROKKA_00001 25 131 23 132 PF14691.1 Fer4_20 Domain 3 110 111 91.1 3.2e-26 1 CL0344
+10FR_NODE_6#PROKKA_00002 28 394 28 394 PF00310.16 GATase_2 Domain 1 361 361 446.4 5.4e-134 1 CL0052
+10FR_NODE_6#PROKKA_00002 471 755 468 755 PF04898.9 Glu_syn_central Domain 4 288 288 358.5 2.3e-107 1 CL0036
+10FR_NODE_6#PROKKA_00002 815 1178 815 1178 PF01645.12 Glu_synthase Family 1 368 368 503.8 2.4e-151 1 CL0036
+10FR_NODE_6#PROKKA_00002 1259 1450 1256 1452 PF01493.14 GXGXG Family 4 200 202 228.0 5.3e-68 1 No_clan
+10FR_NODE_6#PROKKA_00003 6 81 6 82 PF13740.1 ACT_6 Domain 1 75 76 81.8 2.1e-23 1 CL0070
+10FR_NODE_6#PROKKA_00003 196 364 196 364 PF12710.2 HAD Family 1 192 192 66.9 2.5e-18 1 CL0137
+10FR_NODE_6#PROKKA_00004 95 263 94 264 PF02222.17 ATP-grasp Family 2 171 172 138.3 1.5e-40 1 CL0179
+10FR_NODE_6#PROKKA_00005 5 153 4 154 PF00731.15 AIRC Domain 2 149 150 217.4 4.8e-65 1 No_clan
+10FR_NODE_6#PROKKA_00006 98 355 93 355 PF02353.15 CMAS Family 5 273 273 296.5 1.4e-88 1 CL0063
+10FR_NODE_6#PROKKA_00007 44 78 43 79 PF07676.7 PD40 Repeat 2 38 39 35.2 6.5e-09 1 CL0186
+10FR_NODE_6#PROKKA_00007 99 131 98 135 PF07676.7 PD40 Repeat 2 33 39 14.8 0.017 1 CL0186
+10FR_NODE_6#PROKKA_00007 344 368 343 372 PF07676.7 PD40 Repeat 7 33 39 19.4 0.00057 1 CL0186
+10FR_NODE_6#PROKKA_00007 391 409 375 412 PF07676.7 PD40 Repeat 8 26 39 12.3 0.098 1 CL0186
+10FR_NODE_6#PROKKA_00007 481 501 473 505 PF07676.7 PD40 Repeat 11 33 39 12.2 0.1 1 CL0186
+10FR_NODE_6#PROKKA_00007 681 748 680 749 PF14684.1 Tricorn_C1 Domain 2 69 70 76.4 1.1e-21 1 No_clan
+10FR_NODE_6#PROKKA_00007 761 851 761 852 PF14685.1 Tricorn_PDZ Domain 1 87 88 80.6 5.1e-23 1 CL0466
+10FR_NODE_6#PROKKA_00007 881 1036 881 1036 PF03572.13 Peptidase_S41 Family 1 169 169 68.4 4.5e-19 1 CL0127
+10FR_NODE_6#PROKKA_00008 4 214 4 225 PF02811.14 PHP Family 1 170 175 43.3 3.2e-11 1 CL0034
+10FR_NODE_6#PROKKA_00009 1 48 1 48 PF13793.1 Pribosyltran_N Domain 70 116 116 63.1 1.8e-17 1 No_clan
+10FR_NODE_6#PROKKA_00009 130 237 120 238 PF14572.1 Pribosyl_synth Domain 74 183 184 84.5 7.3e-24 1 CL0533
+10FR_NODE_6#PROKKA_00010 6 90 6 90 PF01386.14 Ribosomal_L25p Domain 1 88 88 84.9 2.9e-24 1 No_clan
+10FR_NODE_6#PROKKA_00010 98 180 97 183 PF14693.1 Ribosomal_TL5_C Domain 2 85 88 63.7 1.3e-17 1 No_clan
+10FR_NODE_6#PROKKA_00011 4 185 4 185 PF01195.14 Pept_tRNA_hydro Domain 1 184 184 190.2 2.3e-56 1 No_clan
+10FR_NODE_6#PROKKA_00013 53 132 53 132 PF08545.5 ACP_syn_III Domain 1 80 80 102.2 8.2e-30 1 CL0046
+10FR_NODE_6#PROKKA_00013 184 271 184 271 PF08541.5 ACP_syn_III_C Domain 1 90 90 104.4 2.3e-30 1 CL0046
+10FR_NODE_6#PROKKA_00014 129 287 128 287 PF13377.1 Peripla_BP_3 Domain 2 160 160 108.8 2.5e-31 1 CL0144
+10FR_NODE_6#PROKKA_00015 25 111 25 111 PF13715.1 DUF4480 Repeat 1 88 88 54.3 9.9e-15 1 CL0287
+10FR_NODE_6#PROKKA_00015 121 232 119 232 PF07715.10 Plug Domain 3 108 108 50.6 1.9e-13 1 CL0072
+10FR_NODE_6#PROKKA_00015 626 885 626 885 PF00593.19 TonB_dep_Rec Family 1 277 277 62.5 5.6e-17 1 CL0193
+10FR_NODE_6#PROKKA_00016 41 435 41 435 PF00474.12 SSF Family 1 406 406 242.4 6.5e-72 1 CL0062
+10FR_NODE_6#PROKKA_00017 23 197 3 221 PF12899.2 Glyco_hydro_100 Domain 19 223 436 47.4 8.8e-13 1 CL0059
+10FR_NODE_6#PROKKA_00018 37 156 35 186 PF00485.13 PRK Domain 3 130 194 23.7 2.9e-05 1 CL0023
+11FR_NODE_14#PROKKA_00020 4 317 4 317 PF00389.25 2-Hacid_dh Domain 1 133 133 116.2 6.5e-34 1 CL0325
+11FR_NODE_14#PROKKA_00020 110 285 110 285 PF02826.14 2-Hacid_dh_C Domain 1 178 178 208.1 5.2e-62 1 CL0063
+11FR_NODE_14#PROKKA_00021 304 326 303 326 PF00037.22 Fer4 Domain 2 24 24 31.1 1.1e-07 1 CL0344
+11FR_NODE_14#PROKKA_00022 189 342 173 346 PF00158.21 Sigma54_activat Domain 21 163 168 138.4 1.5e-40 1 CL0023
+11FR_NODE_14#PROKKA_00024 21 165 21 165 PF13492.1 GAF_3 Domain 1 129 129 32.7 6.4e-08 1 CL0161
+11FR_NODE_14#PROKKA_00024 199 365 198 365 PF00158.21 Sigma54_activat Domain 2 168 168 229.7 1.3e-68 1 CL0023
+11FR_NODE_14#PROKKA_00024 462 505 461 505 PF02954.14 HTH_8 Domain 2 42 42 27.5 1.6e-06 1 CL0123
+12FR_NODE_3#PROKKA_00026 38 98 36 100 PF01584.14 CheW Domain 3 63 138 55.5 3.9e-15 1 No_clan
+12FR_NODE_3#PROKKA_00027 4 115 4 116 PF00072.19 Response_reg Domain 1 111 112 97.1 5.9e-28 1 CL0304
+12FR_NODE_3#PROKKA_00028 10 121 10 122 PF00072.19 Response_reg Domain 1 111 112 94.8 2.9e-27 1 CL0304
+12FR_NODE_3#PROKKA_00029 4 121 3 121 PF02951.9 GSH-S_N Domain 2 119 119 147.8 1.1e-43 1 No_clan
+12FR_NODE_3#PROKKA_00029 125 297 125 299 PF02955.11 GSH-S_ATP Domain 1 172 174 236.0 1.3e-70 1 CL0179
+12FR_NODE_3#PROKKA_00030 204 274 203 284 PF03544.9 TonB_C Domain 2 70 79 71.7 4.2e-20 1 CL0428
+12FR_NODE_3#PROKKA_00031 16 172 16 172 PF02622.10 DUF179 Family 1 161 161 176.0 4e-52 1 No_clan
+12FR_NODE_3#PROKKA_00032 11 141 10 143 PF03652.10 UPF0081 Family 2 133 135 126.1 9.4e-37 1 No_clan
+12FR_NODE_3#PROKKA_00033 9 125 3 126 PF00156.22 Pribosyltran Domain 8 124 125 52.4 3.8e-14 1 CL0533
+12FR_NODE_3#PROKKA_00034 20 166 20 166 PF02729.16 OTCace_N Domain 1 142 142 131.3 1.8e-38 1 No_clan
+12FR_NODE_3#PROKKA_00034 172 318 171 319 PF00185.19 OTCace Domain 2 157 158 139.2 1e-40 1 No_clan
+12FR_NODE_3#PROKKA_00035 47 378 47 378 PF13147.1 Amidohydro_4 Domain 1 304 304 90.3 2e-25 1 CL0034
+12FR_NODE_3#PROKKA_00037 10 97 9 98 PF00216.16 Bac_DNA_binding Domain 2 89 90 105.8 8.2e-31 1 CL0548
+12FR_NODE_3#PROKKA_00040 272 695 267 697 PF06808.7 DctM Family 10 414 416 73.1 1.5e-20 1 CL0182
+12FR_NODE_3#PROKKA_00041 3 465 1 466 PF01293.15 PEPCK_ATP Family 4 466 467 681.2 5.8e-205 1 CL0374
+12FR_NODE_3#PROKKA_00042 4 271 4 272 PF01430.14 HSP33 Family 1 279 280 305.2 3.4e-91 1 No_clan
+12FR_NODE_3#PROKKA_00043 15 60 14 60 PF01479.20 S4 Domain 2 48 48 43.1 2e-11 1 CL0492
+12FR_NODE_3#PROKKA_00044 23 198 22 201 PF13419.1 HAD_2 Family 2 173 176 74.7 9.7e-21 1 CL0137
+12FR_NODE_3#PROKKA_00046 2 115 2 116 PF01149.19 Fapy_DNA_glyco Domain 1 115 116 117.4 4.1e-34 1 No_clan
+12FR_NODE_3#PROKKA_00046 130 219 130 222 PF06831.9 H2TH Domain 1 90 93 85.2 1.9e-24 1 CL0303
+12FR_NODE_3#PROKKA_00046 242 269 242 270 PF06827.9 zf-FPG_IleRS Domain 1 28 30 34.9 8.1e-09 1 CL0167
+12FR_NODE_3#PROKKA_00048 13 216 12 226 PF00487.19 FA_desaturase Domain 2 231 257 67.7 1e-18 1 No_clan
+12FR_NODE_3#PROKKA_00048 267 388 263 390 PF01610.12 DDE_Tnp_ISL3 Family 81 203 249 42.1 7.1e-11 1 CL0219
+12FR_NODE_3#PROKKA_00049 66 298 66 299 PF12697.2 Abhydrolase_6 Domain 1 227 228 146.3 1.3e-42 1 CL0028
+12FR_NODE_3#PROKKA_00050 25 201 25 202 PF03602.10 Cons_hypoth95 Family 1 182 183 199.7 2.5e-59 1 CL0063
+12FR_NODE_3#PROKKA_00051 125 201 124 201 PF02881.14 SRP54_N Domain 2 75 75 62.2 3.5e-17 1 No_clan
+12FR_NODE_3#PROKKA_00051 220 420 220 421 PF00448.17 SRP54 Family 1 195 196 266.1 1.4e-79 1 CL0023
+12FR_NODE_3#PROKKA_00052 18 165 18 166 PF00005.22 ABC_tran Domain 1 136 137 116.0 1.4e-33 1 CL0023
+12FR_NODE_3#PROKKA_00053 201 317 199 321 PF02687.16 FtsX Family 3 115 121 40.0 2.6e-10 1 CL0404
+12FR_NODE_3#PROKKA_00054 17 49 16 50 PF00140.15 Sigma70_r1_2 Family 4 36 37 29.8 3.4e-07 1 No_clan
+12FR_NODE_3#PROKKA_00054 54 123 54 124 PF04542.9 Sigma70_r2 Domain 1 70 71 64.2 5.9e-18 1 CL0123
+12FR_NODE_3#PROKKA_00054 229 280 229 280 PF04545.11 Sigma70_r4 Domain 1 50 50 55.7 2.1e-15 1 CL0123
+12FR_NODE_3#PROKKA_00055 6 163 4 163 PF03446.10 NAD_binding_2 Domain 3 163 163 170.7 2.2e-50 1 CL0063
+12FR_NODE_3#PROKKA_00055 165 282 165 285 PF14833.1 NAD_binding_11 Domain 1 119 122 97.3 5.9e-28 1 CL0063
+12FR_NODE_3#PROKKA_00056 21 220 21 220 PF01261.19 AP_endonuc_2 Domain 1 213 213 107.9 4.2e-31 1 CL0036
+12FR_NODE_3#PROKKA_00057 27 136 27 137 PF00072.19 Response_reg Domain 1 111 112 87.8 4.5e-25 1 CL0304
+12FR_NODE_3#PROKKA_00057 171 246 171 246 PF00486.23 Trans_reg_C Domain 1 77 77 96.1 8.1e-28 1 CL0123
+12FR_NODE_3#PROKKA_00058 166 234 166 234 PF00672.20 HAMP Family 3 70 70 49.9 2.6e-13 1 No_clan
+12FR_NODE_3#PROKKA_00058 245 301 240 303 PF00512.20 HisKA Domain 8 66 68 28.2 1.3e-06 1 CL0025
+12FR_NODE_3#PROKKA_00058 348 460 348 462 PF02518.21 HATPase_c Domain 1 109 111 88.4 2.3e-25 1 CL0025
+12FR_NODE_3#PROKKA_00063 111 370 110 370 PF02353.15 CMAS Family 2 273 273 301.3 4.9e-90 1 CL0063
+12FR_NODE_3#PROKKA_00064 9 123 5 124 PF00903.20 Glyoxalase Domain 5 127 128 24.6 1.9e-05 1 CL0104
+12FR_NODE_3#PROKKA_00066 17 140 17 141 PF00892.15 EamA Family 1 125 126 59.3 3.7e-16 1 CL0184
+12FR_NODE_3#PROKKA_00067 56 134 56 135 PF12833.2 HTH_18 Domain 1 80 81 90.6 4.9e-26 1 CL0123
+14FR_NODE_9#PROKKA_00069 9 553 2 554 PF00821.13 PEPCK Family 38 586 587 522.6 9.4e-157 1 CL0374
+14FR_NODE_9#PROKKA_00071 108 361 108 361 PF00425.13 Chorismate_bind Family 1 257 257 280.6 9.9e-84 1 No_clan
+14FR_NODE_9#PROKKA_00071 388 570 387 577 PF01063.14 Aminotran_4 Domain 2 208 231 112.0 2.7e-32 1 No_clan
+14FR_NODE_9#PROKKA_00073 33 257 30 258 PF13531.1 SBP_bac_11 Family 4 229 230 49.3 4.5e-13 1 CL0177
+14FR_NODE_9#PROKKA_00075 320 601 313 604 PF00128.19 Alpha-amylase Domain 8 312 316 56.3 3.1e-15 1 CL0058
+14FR_NODE_9#PROKKA_00076 3 72 3 73 PF00076.17 RRM_1 Domain 1 69 70 82.8 9.4e-24 1 CL0221
+14FR_NODE_9#PROKKA_00077 3 72 3 73 PF00076.17 RRM_1 Domain 1 69 70 84.0 4e-24 1 CL0221
+14FR_NODE_9#PROKKA_00078 3 72 3 73 PF00076.17 RRM_1 Domain 1 69 70 81.0 3.4e-23 1 CL0221
+14FR_NODE_9#PROKKA_00079 8 88 6 89 PF00381.14 PTS-HPr Domain 3 83 84 99.0 1e-28 1 No_clan
+14FR_NODE_9#PROKKA_00080 19 143 19 144 PF05524.8 PEP-utilisers_N Family 1 122 123 85.1 3.1e-24 1 No_clan
+14FR_NODE_9#PROKKA_00080 167 242 162 242 PF00391.18 PEP-utilizers Family 7 81 81 85.9 1e-24 1 No_clan
+14FR_NODE_9#PROKKA_00080 275 558 267 559 PF02896.13 PEP-utilizers_C Domain 9 293 294 351.7 2.1e-105 1 CL0151
+14FR_NODE_9#PROKKA_00081 13 86 11 105 PF02357.14 NusG Family 3 80 92 41.1 1.5e-10 1 CL0439
+14FR_NODE_9#PROKKA_00083 10 183 8 183 PF00753.22 Lactamase_B Domain 3 194 194 59.5 3.3e-16 1 CL0381
+14FR_NODE_9#PROKKA_00083 374 453 362 454 PF00581.15 Rhodanese Domain 12 112 113 68.5 5.7e-19 1 No_clan
+15FR_NODE_1#PROKKA_00087 53 390 53 391 PF00344.15 SecY Family 1 345 346 377.1 6.4e-113 1 No_clan
+15FR_NODE_1#PROKKA_00088 1 37 1 37 PF00444.13 Ribosomal_L36 Domain 1 38 38 75.0 3.1e-21 1 No_clan
+15FR_NODE_1#PROKKA_00089 3 108 3 108 PF00416.17 Ribosomal_S13 Family 1 107 107 122.9 7e-36 1 CL0303
+15FR_NODE_1#PROKKA_00090 19 128 19 128 PF00411.14 Ribosomal_S11 Family 1 110 110 157.1 1.5e-46 1 CL0267
+15FR_NODE_1#PROKKA_00091 2 97 2 97 PF00163.14 Ribosomal_S4 Family 1 94 94 87.5 5.5e-25 1 No_clan
+15FR_NODE_1#PROKKA_00091 99 145 98 145 PF01479.20 S4 Domain 2 48 48 76.5 7.5e-22 1 CL0492
+15FR_NODE_1#PROKKA_00092 28 227 28 228 PF01193.19 RNA_pol_L Domain 1 65 66 67.0 5.5e-19 1 CL0509
+15FR_NODE_1#PROKKA_00092 64 153 56 156 PF01000.21 RNA_pol_A_bac Domain 15 108 112 81.8 3.6e-23 1 No_clan
+15FR_NODE_1#PROKKA_00092 245 306 241 307 PF03118.10 RNA_pol_A_CTD Domain 5 66 67 82.6 9e-24 1 CL0198
+15FR_NODE_1#PROKKA_00093 20 116 20 116 PF01196.14 Ribosomal_L17 Family 1 97 97 125.2 1.1e-36 1 No_clan
+15FR_NODE_1#PROKKA_00094 5 307 5 311 PF07992.9 Pyr_redox_2 Domain 1 196 201 76.9 1.7e-21 1 CL0063
+15FR_NODE_1#PROKKA_00094 175 225 175 237 PF00070.22 Pyr_redox Domain 1 51 80 28.3 1.7e-06 1 CL0063
+15FR_NODE_1#PROKKA_00094 343 445 340 447 PF02852.17 Pyr_redox_dim Domain 4 108 110 53.1 2.7e-14 1 No_clan
+15FR_NODE_1#PROKKA_00095 23 182 14 182 PF13489.1 Methyltransf_23 Domain 10 161 161 68.0 7.3e-19 1 CL0063
+15FR_NODE_1#PROKKA_00097 2 102 1 103 PF00939.14 Na_sulph_symp Family 364 466 471 30.7 1.5e-07 1 CL0182
+15FR_NODE_1#PROKKA_00098 235 263 230 265 PF07849.6 DUF1641 Family 5 33 42 22.6 5.5e-05 1 No_clan
+15FR_NODE_1#PROKKA_00099 7 322 6 324 PF07992.9 Pyr_redox_2 Domain 2 199 201 34.1 2.4e-08 1 CL0063
+15FR_NODE_1#PROKKA_00100 39 537 4 537 PF03600.11 CitMHS Family 38 351 351 115.1 2.5e-33 1 CL0182
+15FR_NODE_1#PROKKA_00100 219 287 218 289 PF02080.16 TrkA_C Domain 2 69 71 47.1 1.3e-12 1 No_clan
+15FR_NODE_1#PROKKA_00100 309 370 309 375 PF02080.16 TrkA_C Domain 1 61 71 35.0 7.6e-09 1 No_clan
+15FR_NODE_1#PROKKA_00101 797 859 746 860 PF00005.22 ABC_tran Domain 84 136 137 23.2 6.6e-05 1 CL0023
+15FR_NODE_1#PROKKA_00102 14 459 12 472 PF13520.1 AA_permease_2 Family 4 419 426 134.3 3.9e-39 1 CL0062
+15FR_NODE_1#PROKKA_00103 130 164 124 183 PF13188.1 PAS_8 Domain 10 43 64 17.5 0.0027 1 CL0183
+15FR_NODE_1#PROKKA_00103 249 357 248 357 PF00989.19 PAS Domain 2 113 113 44.6 1e-11 1 CL0183
+15FR_NODE_1#PROKKA_00103 384 485 382 486 PF13426.1 PAS_9 Domain 3 103 104 45.2 9.1e-12 1 CL0183
+15FR_NODE_1#PROKKA_00103 500 581 499 608 PF00989.19 PAS Domain 2 85 113 31.6 1.1e-07 1 CL0183
+15FR_NODE_1#PROKKA_00103 622 777 622 780 PF00990.16 GGDEF Domain 1 158 161 138.4 1.5e-40 1 CL0276
+15FR_NODE_1#PROKKA_00103 801 973 799 974 PF00563.15 EAL Domain 3 174 236 129.8 1.1e-37 1 No_clan
+15FR_NODE_1#PROKKA_00105 4 334 3 334 PF00456.16 Transketolase_N Domain 2 333 333 518.3 6.2e-156 1 CL0254
+15FR_NODE_1#PROKKA_00105 354 526 353 527 PF02779.19 Transket_pyr Domain 2 177 178 155.3 1.1e-45 1 CL0254
+15FR_NODE_1#PROKKA_00105 548 656 541 656 PF02780.15 Transketolase_C Domain 7 124 124 36.4 4.1e-09 1 No_clan
+15FR_NODE_1#PROKKA_00106 2 155 2 155 PF00044.19 Gp_dh_N Domain 1 151 151 201.6 5.6e-60 1 CL0063
+15FR_NODE_1#PROKKA_00106 160 315 160 315 PF02800.15 Gp_dh_C Domain 1 157 157 210.0 1.1e-62 1 CL0139
+15FR_NODE_1#PROKKA_00107 6 379 5 379 PF00162.14 PGK Domain 2 384 384 466.3 5.2e-140 1 No_clan
+15FR_NODE_1#PROKKA_00108 9 344 8 349 PF00224.16 PK Family 2 341 348 392.0 1.6e-117 1 CL0151
+15FR_NODE_1#PROKKA_00108 363 476 362 477 PF02887.11 PK_C Domain 2 116 117 97.0 4.9e-28 1 No_clan
+15FR_NODE_1#PROKKA_00109 65 165 62 166 PF00034.16 Cytochrom_C Domain 4 90 91 26.0 1.2e-05 1 CL0318
+15FR_NODE_1#PROKKA_00109 332 407 331 407 PF13442.1 Cytochrome_CBB3 Domain 2 67 67 39.7 4e-10 1 CL0318
+15FR_NODE_1#PROKKA_00109 437 510 435 510 PF13442.1 Cytochrome_CBB3 Domain 4 67 67 52.4 4.3e-14 1 CL0318
+15FR_NODE_1#PROKKA_00110 7 356 6 358 PF02322.10 Cyto_ox_2 Family 2 323 328 172.6 1.1e-50 1 No_clan
+15FR_NODE_1#PROKKA_00111 86 839 84 846 PF01804.13 Penicil_amidase Family 3 722 735 358.9 8.7e-107 1 CL0052
+15FR_NODE_1#PROKKA_00112 4 154 4 178 PF01656.18 CbiA Domain 1 163 195 70.7 1e-19 1 CL0023
+15FR_NODE_1#PROKKA_00113 10 198 1 199 PF01734.17 Patatin Family 21 203 204 53.0 4e-14 1 CL0323
+15FR_NODE_1#PROKKA_00114 1 285 1 287 PF03668.10 ATP_bind_2 Family 1 282 284 276.2 2.3e-82 1 CL0023
+15FR_NODE_1#PROKKA_00115 4 95 2 95 PF02482.14 Ribosomal_S30AE Family 3 97 97 101.0 3.5e-29 1 No_clan
+15FR_NODE_1#PROKKA_00116 70 263 63 264 PF04963.8 Sigma54_CBD Domain 7 193 194 165.8 7.3e-49 1 CL0123
+15FR_NODE_1#PROKKA_00116 277 435 276 435 PF04552.8 Sigma54_DBD Domain 2 160 160 198.0 6.4e-59 1 CL0123
+15FR_NODE_1#PROKKA_00117 20 166 19 166 PF00005.22 ABC_tran Domain 2 137 137 120.4 6.3e-35 1 CL0023
+15FR_NODE_1#PROKKA_00117 215 236 214 236 PF12399.3 BCA_ABC_TP_C Family 2 23 23 26.2 4.2e-06 1 No_clan
+15FR_NODE_1#PROKKA_00118 40 151 40 153 PF03968.9 OstA Family 1 111 113 60.7 1.1e-16 1 CL0259
+15FR_NODE_1#PROKKA_00119 19 189 16 189 PF06835.8 LptC Family 4 176 176 104.3 4.4e-30 1 CL0259
+15FR_NODE_1#PROKKA_00120 76 143 71 151 PF08282.7 Hydrolase_3 Domain 179 246 254 29.6 4.7e-07 1 CL0137
+15FR_NODE_1#PROKKA_00121 44 174 43 175 PF01380.17 SIS Family 2 130 131 106.9 5.4e-31 1 CL0067
+15FR_NODE_1#PROKKA_00121 204 260 204 261 PF00571.23 CBS Domain 1 55 57 35.6 5.7e-09 1 No_clan
+15FR_NODE_1#PROKKA_00121 273 322 270 324 PF00571.23 CBS Domain 4 54 57 33.9 1.9e-08 1 No_clan
+15FR_NODE_1#PROKKA_00122 10 74 8 75 PF01722.13 BolA Family 2 75 76 63.0 1.8e-17 1 No_clan
+15FR_NODE_1#PROKKA_00123 7 407 6 407 PF00275.15 EPSP_synthase Family 2 419 419 391.1 4.2e-117 1 CL0290
+15FR_NODE_1#PROKKA_00124 3 76 3 77 PF13417.1 GST_N_3 Domain 1 74 75 60.1 1.7e-16 1 CL0172
+15FR_NODE_1#PROKKA_00124 117 183 86 183 PF00043.20 GST_C Domain 28 95 95 28.0 1.6e-06 1 CL0497
+15FR_NODE_1#PROKKA_00125 8 105 6 107 PF04386.8 SspB Family 5 111 155 98.2 3.2e-28 1 No_clan
+16FR_NODE_10#PROKKA_00128 28 374 28 377 PF13458.1 Peripla_BP_6 Family 1 339 343 198.0 2.5e-58 1 CL0144
+16FR_NODE_10#PROKKA_00129 5 60 4 62 PF01842.20 ACT Domain 2 59 66 37.5 1.1e-09 1 CL0070
+16FR_NODE_10#PROKKA_00129 72 123 70 136 PF01842.20 ACT Domain 3 52 66 21.6 0.00011 1 CL0070
+16FR_NODE_10#PROKKA_00130 3 141 3 141 PF01118.19 Semialdhyde_dh Domain 1 121 121 103.3 9.8e-30 1 CL0063
+16FR_NODE_10#PROKKA_00130 158 316 158 316 PF02774.13 Semialdhyde_dhC Domain 1 184 184 75.1 5.8e-21 1 CL0139
+16FR_NODE_10#PROKKA_00131 82 174 69 183 PF01551.17 Peptidase_M23 Family 4 88 96 24.1 2.7e-05 1 CL0105
+16FR_NODE_10#PROKKA_00132 246 272 244 273 PF13174.1 TPR_6 Repeat 6 32 33 12.0 0.22 1 CL0020
+16FR_NODE_10#PROKKA_00132 315 338 312 341 PF00515.23 TPR_1 Repeat 8 31 34 13.4 0.043 1 CL0020
+16FR_NODE_10#PROKKA_00133 27 197 27 198 PF01734.17 Patatin Family 1 203 204 60.8 1.6e-16 1 CL0323
+16FR_NODE_10#PROKKA_00134 94 231 94 231 PF13365.1 Trypsin_2 Domain 1 120 120 75.7 2.8e-21 1 CL0124
+16FR_NODE_10#PROKKA_00134 267 357 267 358 PF13180.1 PDZ_2 Domain 1 81 82 62.5 2.4e-17 1 CL0466
+16FR_NODE_10#PROKKA_00136 3 63 2 65 PF07879.6 PHB_acc_N Domain 2 62 64 80.9 3.8e-23 1 No_clan
+16FR_NODE_10#PROKKA_00137 8 285 8 286 PF03007.11 WES_acyltransf Domain 1 262 263 127.4 6.8e-37 1 CL0149
+16FR_NODE_10#PROKKA_00137 326 468 322 471 PF06974.8 DUF1298 Family 6 149 153 56.4 2.8e-15 1 No_clan
+16FR_NODE_10#PROKKA_00138 12 310 11 345 PF02374.10 ArsA_ATPase Family 2 273 305 104.5 5.1e-30 1 CL0023
+16FR_NODE_10#PROKKA_00139 32 187 31 194 PF02374.10 ArsA_ATPase Family 2 154 305 78.9 3.3e-22 1 CL0023
+16FR_NODE_10#PROKKA_00139 194 258 185 267 PF02374.10 ArsA_ATPase Family 193 256 305 24.7 1e-05 1 CL0023
+16FR_NODE_10#PROKKA_00140 3 61 2 66 PF07879.6 PHB_acc_N Domain 2 60 64 56.3 1.9e-15 1 No_clan
+16FR_NODE_10#PROKKA_00142 9 178 9 179 PF01734.17 Patatin Family 1 203 204 72.1 5.7e-20 1 CL0323
+16FR_NODE_10#PROKKA_00144 55 308 54 309 PF01761.15 DHQ_synthase Domain 2 260 261 306.5 9.6e-92 1 CL0224
+16FR_NODE_10#PROKKA_00145 87 330 69 335 PF00793.15 DAHP_synth_1 Domain 9 267 272 262.7 2.1e-78 1 CL0036
+16FR_NODE_10#PROKKA_00147 14 75 12 75 PF00392.16 GntR Family 3 64 64 76.3 8.8e-22 1 CL0123
+2FR_NODE_5#PROKKA_00149 53 83 11 83 PF00005.22 ABC_tran Domain 107 137 137 23.1 6.8e-05 1 CL0023
+2FR_NODE_5#PROKKA_00149 133 155 133 155 PF12399.3 BCA_ABC_TP_C Family 1 23 23 31.2 1.1e-07 1 No_clan
+2FR_NODE_5#PROKKA_00150 39 182 37 183 PF00005.22 ABC_tran Domain 3 136 137 96.1 2e-27 1 CL0023
+2FR_NODE_5#PROKKA_00151 72 372 72 373 PF01546.23 Peptidase_M20 Family 1 188 189 118.9 1.7e-34 1 CL0035
+2FR_NODE_5#PROKKA_00151 175 268 175 279 PF07687.9 M20_dimer Domain 1 97 112 79.2 1.7e-22 1 No_clan
+2FR_NODE_5#PROKKA_00152 531 547 530 547 PF00353.14 HemolysinCabind Repeat 2 18 18 16.6 0.0069 1 No_clan
+2FR_NODE_5#PROKKA_00152 548 565 548 565 PF00353.14 HemolysinCabind Repeat 1 18 18 15.6 0.014 1 No_clan
+2FR_NODE_5#PROKKA_00152 566 583 566 583 PF00353.14 HemolysinCabind Repeat 1 18 18 21.4 0.0002 1 No_clan
+2FR_NODE_5#PROKKA_00152 584 599 584 600 PF00353.14 HemolysinCabind Repeat 1 16 18 13.1 0.09 1 No_clan
+2FR_NODE_5#PROKKA_00152 2919 2935 2919 2936 PF00353.14 HemolysinCabind Repeat 1 17 18 8.9 2.2 1 No_clan
+2FR_NODE_5#PROKKA_00152 2937 2954 2937 2954 PF00353.14 HemolysinCabind Repeat 1 18 18 16.4 0.0078 1 No_clan
+2FR_NODE_5#PROKKA_00152 2955 2972 2955 2972 PF00353.14 HemolysinCabind Repeat 1 18 18 18.0 0.0025 1 No_clan
+2FR_NODE_5#PROKKA_00152 2973 2989 2973 2989 PF00353.14 HemolysinCabind Repeat 1 17 18 12.0 0.2 1 No_clan
+2FR_NODE_5#PROKKA_00152 3035 3051 3034 3051 PF00353.14 HemolysinCabind Repeat 2 18 18 7.7 5.1 1 No_clan
+2FR_NODE_5#PROKKA_00152 3052 3068 3052 3068 PF00353.14 HemolysinCabind Repeat 1 17 18 12.1 0.2 1 No_clan
+2FR_NODE_5#PROKKA_00152 3190 3362 3182 3367 PF13229.1 Beta_helix Family 31 149 158 22.7 6.6e-05 1 CL0268
+2FR_NODE_5#PROKKA_00152 3488 3504 3487 3504 PF00353.14 HemolysinCabind Repeat 2 18 18 15.1 0.022 1 No_clan
+2FR_NODE_5#PROKKA_00152 3496 3513 3496 3513 PF00353.14 HemolysinCabind Repeat 1 18 18 12.2 0.19 1 No_clan
+2FR_NODE_5#PROKKA_00152 3506 3522 3505 3522 PF00353.14 HemolysinCabind Repeat 2 18 18 10.0 0.93 1 No_clan
+2FR_NODE_5#PROKKA_00152 3871 3888 3871 3888 PF00353.14 HemolysinCabind Repeat 1 18 18 10.0 0.94 1 No_clan
+2FR_NODE_5#PROKKA_00152 3890 3905 3889 3905 PF00353.14 HemolysinCabind Repeat 2 17 18 8.3 3.3 1 No_clan
+2FR_NODE_5#PROKKA_00152 4250 4266 4249 4266 PF00353.14 HemolysinCabind Repeat 2 18 18 12.6 0.14 1 No_clan
+2FR_NODE_5#PROKKA_00152 4280 4294 4278 4294 PF00353.14 HemolysinCabind Repeat 4 18 18 10.8 0.5 1 No_clan
+2FR_NODE_5#PROKKA_00152 4296 4311 4295 4311 PF00353.14 HemolysinCabind Repeat 2 17 18 7.2 7.4 1 No_clan
+2FR_NODE_5#PROKKA_00152 4367 4383 4367 4384 PF00353.14 HemolysinCabind Repeat 1 17 18 9.7 1.1 1 No_clan
+2FR_NODE_5#PROKKA_00152 4428 4444 4428 4445 PF00353.14 HemolysinCabind Repeat 1 17 18 13.6 0.066 1 No_clan
+2FR_NODE_5#PROKKA_00152 4564 4693 4557 4717 PF13229.1 Beta_helix Family 9 137 158 34.5 1.5e-08 1 CL0268
+2FR_NODE_5#PROKKA_00152 4728 4852 4720 4868 PF13229.1 Beta_helix Family 2 132 158 21.8 0.00013 1 CL0268
+2FR_NODE_5#PROKKA_00152 5013 5030 5013 5030 PF00353.14 HemolysinCabind Repeat 1 18 18 9.5 1.3 1 No_clan
+2FR_NODE_5#PROKKA_00152 5031 5047 5031 5047 PF00353.14 HemolysinCabind Repeat 1 17 18 8.4 3 1 No_clan
+2FR_NODE_5#PROKKA_00152 5102 5117 5101 5117 PF00353.14 HemolysinCabind Repeat 2 17 18 12.4 0.15 1 No_clan
+2FR_NODE_5#PROKKA_00152 5162 5179 5162 5179 PF00353.14 HemolysinCabind Repeat 1 18 18 13.4 0.076 1 No_clan
+2FR_NODE_5#PROKKA_00152 5180 5196 5180 5196 PF00353.14 HemolysinCabind Repeat 1 17 18 14.2 0.043 1 No_clan
+2FR_NODE_5#PROKKA_00152 5270 5433 5258 5438 PF13229.1 Beta_helix Family 5 158 158 31.4 1.4e-07 1 CL0268
+2FR_NODE_5#PROKKA_00152 5845 5862 5845 5862 PF00353.14 HemolysinCabind Repeat 1 18 18 13.0 0.097 1 No_clan
+2FR_NODE_5#PROKKA_00152 5864 5876 5863 5877 PF00353.14 HemolysinCabind Repeat 2 14 18 8.1 3.9 1 No_clan
+2FR_NODE_5#PROKKA_00152 6026 6122 5998 6129 PF05048.8 NosD Domain 80 169 236 25.3 7e-06 1 CL0268
+2FR_NODE_5#PROKKA_00152 6498 6514 6497 6514 PF00353.14 HemolysinCabind Repeat 2 18 18 13.0 0.099 1 No_clan
+2FR_NODE_5#PROKKA_00152 6515 6532 6515 6532 PF00353.14 HemolysinCabind Repeat 1 18 18 14.0 0.047 1 No_clan
+2FR_NODE_5#PROKKA_00153 56 244 56 244 PF02321.13 OEP Family 1 188 188 79.2 2.7e-22 1 CL0105
+2FR_NODE_5#PROKKA_00153 265 439 264 445 PF02321.13 OEP Family 2 179 188 92.6 2.1e-26 1 CL0105
+2FR_NODE_5#PROKKA_00154 54 176 50 178 PF03412.10 Peptidase_C39 Family 10 129 131 37.1 2.4e-09 1 CL0125
+2FR_NODE_5#PROKKA_00154 209 469 206 475 PF00664.18 ABC_membrane Family 4 269 275 49.9 2.7e-13 1 CL0241
+2FR_NODE_5#PROKKA_00154 538 687 538 687 PF00005.22 ABC_tran Domain 1 137 137 123.0 9.8e-36 1 CL0023
+2FR_NODE_5#PROKKA_00155 66 358 63 364 PF00529.15 HlyD Family 4 296 305 85.0 5.3e-24 1 CL0105
+2FR_NODE_5#PROKKA_00156 56 283 41 303 PF07470.8 Glyco_hydro_88 Family 22 210 336 32.8 3.6e-08 1 CL0059
+2FR_NODE_5#PROKKA_00157 1 219 1 221 PF09140.6 MipZ Family 32 258 261 232.4 4.5e-69 1 CL0023
+3FR_NODE_4#PROKKA_00158 2 129 1 132 PF02653.11 BPD_transp_2 Family 136 266 267 69.5 2e-19 1 CL0142
+3FR_NODE_4#PROKKA_00159 32 292 31 294 PF02653.11 BPD_transp_2 Family 2 264 267 115.4 2e-33 1 CL0142
+3FR_NODE_4#PROKKA_00160 19 169 19 169 PF00005.22 ABC_tran Domain 1 137 137 100.7 7.5e-29 1 CL0023
+3FR_NODE_4#PROKKA_00160 217 239 217 239 PF12399.3 BCA_ABC_TP_C Family 1 23 23 39.0 4.1e-10 1 No_clan
+3FR_NODE_4#PROKKA_00160 280 423 280 424 PF00005.22 ABC_tran Domain 1 136 137 94.9 4.8e-27 1 CL0023
+3FR_NODE_4#PROKKA_00162 30 154 29 155 PF08240.7 ADH_N Domain 2 108 109 96.3 8.4e-28 1 CL0296
+3FR_NODE_4#PROKKA_00162 197 316 197 326 PF00107.21 ADH_zinc_N Family 1 120 130 111.4 2e-32 1 CL0063
+3FR_NODE_4#PROKKA_00163 15 470 15 471 PF00171.17 Aldedh Family 1 461 462 520.8 2.2e-156 1 CL0099
+3FR_NODE_4#PROKKA_00164 5 139 1 139 PF12276.3 DUF3617 Family 8 162 162 94.3 4.9e-27 1 No_clan
+3FR_NODE_4#PROKKA_00165 30 426 28 427 PF00501.23 AMP-binding Family 3 416 417 314.2 8.6e-94 1 CL0378
+3FR_NODE_4#PROKKA_00165 436 509 435 509 PF13193.1 AMP-binding_C Domain 2 73 73 48.3 1.4e-12 1 CL0531
+3FR_NODE_4#PROKKA_00166 6 117 5 117 PF02771.11 Acyl-CoA_dh_N Domain 2 113 113 101.5 3.7e-29 1 CL0544
+3FR_NODE_4#PROKKA_00166 121 172 121 172 PF02770.14 Acyl-CoA_dh_M Domain 1 52 52 81.9 1.6e-23 1 No_clan
+3FR_NODE_4#PROKKA_00166 232 378 230 379 PF00441.19 Acyl-CoA_dh_1 Domain 3 149 150 168.8 8e-50 1 CL0087
+3FR_NODE_4#PROKKA_00167 28 77 28 79 PF09339.5 HTH_IclR Domain 1 50 52 57.9 5.3e-16 1 CL0123
+3FR_NODE_4#PROKKA_00167 145 264 142 269 PF01614.13 IclR Family 4 124 129 44.6 1e-11 1 CL0161
+3FR_NODE_4#PROKKA_00168 3 267 1 268 PF00108.18 Thiolase_N Domain 3 263 264 256.4 2e-76 1 CL0046
+3FR_NODE_4#PROKKA_00168 276 399 275 399 PF02803.13 Thiolase_C Domain 2 123 123 149.2 3.3e-44 1 CL0046
+3FR_NODE_4#PROKKA_00169 19 129 17 129 PF02771.11 Acyl-CoA_dh_N Domain 3 113 113 109.8 1e-31 1 CL0544
+3FR_NODE_4#PROKKA_00169 133 184 133 185 PF02770.14 Acyl-CoA_dh_M Domain 1 52 52 65.7 1.9e-18 1 No_clan
+3FR_NODE_4#PROKKA_00169 235 380 234 382 PF00441.19 Acyl-CoA_dh_1 Domain 3 148 150 94.1 8e-27 1 CL0087
+3FR_NODE_4#PROKKA_00170 7 166 5 169 PF02776.13 TPP_enzyme_N Domain 3 164 172 157.0 3e-46 1 CL0254
+3FR_NODE_4#PROKKA_00170 234 362 232 362 PF00205.17 TPP_enzyme_M Domain 3 137 137 56.3 2.7e-15 1 CL0085
+3FR_NODE_4#PROKKA_00170 426 568 424 572 PF02775.16 TPP_enzyme_C Domain 3 149 153 70.9 8e-20 1 CL0254
+3FR_NODE_4#PROKKA_00171 26 383 16 396 PF00144.19 Beta-lactamase Domain 8 311 330 229.7 4.4e-68 1 CL0013
+3FR_NODE_4#PROKKA_00172 20 443 16 444 PF00501.23 AMP-binding Family 5 416 417 305.0 5.3e-91 1 CL0378
+3FR_NODE_4#PROKKA_00172 453 527 452 527 PF13193.1 AMP-binding_C Domain 2 73 73 50.5 2.8e-13 1 CL0531
+3FR_NODE_4#PROKKA_00173 59 137 59 137 PF03061.17 4HBT Domain 1 79 79 56.7 1.8e-15 1 CL0050
+3FR_NODE_4#PROKKA_00174 8 178 7 180 PF00106.20 adh_short Domain 2 165 167 109.7 1.3e-31 1 CL0063
+3FR_NODE_4#PROKKA_00175 12 137 12 163 PF13279.1 4HBT_2 Domain 1 110 121 26.3 7.9e-06 1 CL0050
+3FR_NODE_4#PROKKA_00175 230 300 224 304 PF01643.12 Acyl-ACP_TE Family 72 142 261 23.4 2.4e-05 1 CL0050
+3FR_NODE_4#PROKKA_00177 21 70 21 71 PF09339.5 HTH_IclR Domain 1 50 52 59.6 1.6e-16 1 CL0123
+3FR_NODE_4#PROKKA_00177 140 261 136 263 PF01614.13 IclR Family 6 128 129 41.8 7.2e-11 1 CL0161
+3FR_NODE_4#PROKKA_00178 11 428 7 429 PF13609.1 Porin_4 Domain 3 310 311 64.8 8.8e-18 1 CL0193
+3FR_NODE_4#PROKKA_00179 30 453 28 455 PF00501.23 AMP-binding Family 3 415 417 340.3 1.1e-101 1 CL0378
+3FR_NODE_4#PROKKA_00179 463 540 463 540 PF13193.1 AMP-binding_C Domain 1 73 73 61.6 1e-16 1 CL0531
+3FR_NODE_4#PROKKA_00180 98 286 98 293 PF00528.17 BPD_transp_1 Family 1 177 185 78.3 4.9e-22 1 CL0404
+3FR_NODE_4#PROKKA_00181 99 312 97 315 PF00528.17 BPD_transp_1 Family 3 175 185 68.4 5.2e-19 1 CL0404
+3FR_NODE_4#PROKKA_00182 36 326 28 327 PF12849.2 PBP_like_2 Family 9 280 281 165.7 1.5e-48 1 CL0177
+3FR_NODE_4#PROKKA_00183 58 125 53 125 PF05598.6 DUF772 Domain 4 77 77 56.5 1.9e-15 1 No_clan
+3FR_NODE_4#PROKKA_00183 370 434 358 435 PF13751.1 DDE_Tnp_1_6 Domain 60 124 125 51.6 8.2e-14 1 CL0219
+6FR_NODE_12#PROKKA_00187 9 201 9 201 PF02223.12 Thymidylate_kin Domain 1 186 186 158.8 9.1e-47 1 CL0023
+6FR_NODE_12#PROKKA_00188 170 427 166 444 PF04616.9 Glyco_hydro_43 Family 7 257 286 39.4 3.4e-10 1 CL0143
+6FR_NODE_12#PROKKA_00190 666 746 666 746 PF06429.8 Flg_bbr_C Domain 1 74 74 70.0 1.2e-19 1 No_clan
+6FR_NODE_12#PROKKA_00191 23 225 17 225 PF00753.22 Lactamase_B Domain 7 194 194 56.0 3.7e-15 1 CL0381
+6FR_NODE_12#PROKKA_00192 8 117 7 118 PF02771.11 Acyl-CoA_dh_N Domain 3 112 113 97.3 7.8e-28 1 CL0544
+6FR_NODE_12#PROKKA_00192 122 173 122 173 PF02770.14 Acyl-CoA_dh_M Domain 1 52 52 62.7 1.6e-17 1 No_clan
+6FR_NODE_12#PROKKA_00192 229 378 229 378 PF00441.19 Acyl-CoA_dh_1 Domain 1 150 150 178.1 1.1e-52 1 CL0087
+6FR_NODE_12#PROKKA_00193 28 180 23 185 PF01012.16 ETF Domain 7 159 164 126.3 8.6e-37 1 CL0039
+6FR_NODE_12#PROKKA_00194 11 171 10 172 PF01012.16 ETF Domain 2 163 164 137.8 2.6e-40 1 CL0039
+6FR_NODE_12#PROKKA_00194 211 293 209 294 PF00766.14 ETF_alpha Domain 3 85 86 97.6 2.3e-28 1 CL0085
+6FR_NODE_12#PROKKA_00195 35 152 34 161 PF00293.23 NUDIX Domain 2 125 135 63.7 1.3e-17 1 CL0261
+6FR_NODE_12#PROKKA_00197 9 259 8 260 PF00378.15 ECH Family 2 244 245 159.0 1.1e-46 1 CL0127
+7FR_NODE_8#PROKKA_00202 44 150 40 159 PF00156.22 Pribosyltran Domain 5 110 125 31.2 1.4e-07 1 CL0533
+7FR_NODE_8#PROKKA_00206 63 139 61 139 PF03703.9 bPH_2 Domain 3 80 80 32.1 8.2e-08 1 CL0266
+7FR_NODE_8#PROKKA_00209 22 225 19 226 PF01791.4 DeoC Domain 4 235 236 105.3 2.8e-30 1 CL0036
+7FR_NODE_8#PROKKA_00210 3 437 1 440 PF03972.9 MmgE_PrpD Family 3 442 445 391.4 3.1e-117 1 No_clan
+7FR_NODE_8#PROKKA_00211 19 73 19 73 PF01381.17 HTH_3 Domain 1 55 55 52.0 4.4e-14 1 CL0123
+7FR_NODE_8#PROKKA_00211 85 369 84 370 PF03480.8 SBP_bac_7 Family 2 285 286 150.1 6.6e-44 1 CL0177
+7FR_NODE_8#PROKKA_00212 19 399 18 400 PF03435.13 Saccharop_dh Family 2 385 386 256.9 2.9e-76 1 CL0063
+7FR_NODE_8#PROKKA_00213 13 65 11 66 PF12911.2 OppC_N Domain 3 55 56 28.7 5.8e-07 1 No_clan
+7FR_NODE_8#PROKKA_00213 112 295 112 296 PF00528.17 BPD_transp_1 Family 1 184 185 107.3 6.2e-31 1 CL0404
+7FR_NODE_8#PROKKA_00214 112 303 112 304 PF00528.17 BPD_transp_1 Family 1 184 185 152.4 9e-45 1 CL0404
+7FR_NODE_8#PROKKA_00215 73 420 72 425 PF00496.17 SBP_bac_5 Domain 2 369 374 316.6 1.8e-94 1 CL0177
+7FR_NODE_8#PROKKA_00216 32 182 31 183 PF00005.22 ABC_tran Domain 2 136 137 113.9 6.3e-33 1 CL0023
+7FR_NODE_8#PROKKA_00216 234 299 234 299 PF08352.7 oligo_HPY Family 1 64 64 64.8 6.7e-18 1 No_clan
+7FR_NODE_8#PROKKA_00217 6 164 5 165 PF00005.22 ABC_tran Domain 2 136 137 97.3 8.4e-28 1 CL0023
+7FR_NODE_8#PROKKA_00217 216 282 216 282 PF08352.7 oligo_HPY Family 1 64 64 69.9 1.7e-19 1 No_clan
+7FR_NODE_8#PROKKA_00218 209 374 209 379 PF00270.24 DEAD Domain 1 164 169 35.3 7.1e-09 1 CL0023
+7FR_NODE_8#PROKKA_00219 2 74 1 74 PF02082.15 Rrf2 Family 10 83 83 75.8 2.1e-21 1 CL0123
+7FR_NODE_8#PROKKA_00220 13 56 13 57 PF08369.5 PCP_red Family 1 44 45 44.1 1.3e-11 1 No_clan
+7FR_NODE_8#PROKKA_00220 97 266 87 281 PF01077.17 NIR_SIR Family 15 122 157 46.4 2.5e-12 1 No_clan
+7FR_NODE_8#PROKKA_00220 176 218 175 219 PF12838.2 Fer4_7 Domain 2 51 52 35.6 8.4e-09 1 CL0344
+7FR_NODE_8#PROKKA_00222 13 87 13 95 PF01584.14 CheW Domain 1 75 138 61.7 4.7e-17 1 No_clan
+7FR_NODE_8#PROKKA_00222 91 159 90 159 PF13682.1 CZB Domain 2 70 70 60.8 1e-16 1 No_clan
+7FR_NODE_8#PROKKA_00222 185 269 133 271 PF01584.14 CheW Domain 65 136 138 30.6 1.9e-07 1 No_clan
+7FR_NODE_8#PROKKA_00223 23 104 23 104 PF13466.1 STAS_2 Domain 1 80 80 41.1 1.3e-10 1 CL0502
+7FR_NODE_8#PROKKA_00223 163 376 162 376 PF02405.11 Permease Family 2 215 215 235.4 4.6e-70 1 No_clan
+7FR_NODE_8#PROKKA_00224 23 172 23 172 PF00005.22 ABC_tran Domain 1 137 137 105.2 3.2e-30 1 CL0023
+8FR_NODE_2#PROKKA_00225 1 255 1 255 PF03054.11 tRNA_Me_trans Family 97 356 356 267.1 1.5e-79 1 CL0039
+8FR_NODE_2#PROKKA_00226 27 209 26 209 PF07947.9 YhhN Family 2 185 185 147.3 2.9e-43 1 No_clan
+8FR_NODE_2#PROKKA_00227 70 264 70 264 PF12695.2 Abhydrolase_5 Domain 1 145 145 81.3 5.5e-23 1 CL0028
+8FR_NODE_2#PROKKA_00228 322 426 233 426 PF00795.17 CN_hydrolase Family 98 186 186 33.7 2e-08 1 No_clan
+8FR_NODE_2#PROKKA_00229 9 158 8 158 PF00881.19 Nitroreductase Domain 2 165 165 123.5 6.8e-36 1 CL0529
+8FR_NODE_2#PROKKA_00230 10 94 9 95 PF02357.14 NusG Family 2 91 92 66.1 2.4e-18 1 CL0439
+8FR_NODE_2#PROKKA_00231 6 153 6 153 PF02674.11 Colicin_V Family 1 146 146 104.2 5e-30 1 CL0292
+8FR_NODE_2#PROKKA_00232 53 146 39 147 PF00657.17 Lipase_GDSL Family 142 233 234 36.0 6e-09 1 CL0264
+8FR_NODE_2#PROKKA_00234 220 403 132 407 PF01609.16 DDE_Tnp_1 Domain 43 209 213 38.5 8.1e-10 1 CL0219
+8FR_NODE_2#PROKKA_00235 203 328 203 329 PF10017.4 Methyltransf_33 Family 1 126 127 124.0 3e-36 1 No_clan
+8FR_NODE_2#PROKKA_00236 10 114 9 116 PF00581.15 Rhodanese Domain 2 111 113 43.6 3e-11 1 No_clan
+8FR_NODE_2#PROKKA_00236 149 262 144 264 PF00581.15 Rhodanese Domain 10 111 113 55.3 7e-15 1 No_clan
+8FR_NODE_2#PROKKA_00236 297 417 294 418 PF00581.15 Rhodanese Domain 4 112 113 51.8 8.8e-14 1 No_clan
+8FR_NODE_2#PROKKA_00237 1 88 1 90 PF04248.7 DUF427 Family 1 93 95 98.9 9.1e-29 1 No_clan
+8FR_NODE_2#PROKKA_00239 12 96 6 98 PF00355.21 Rieske Domain 6 95 97 48.5 4.8e-13 1 CL0516
+8FR_NODE_2#PROKKA_00239 113 277 112 280 PF02776.13 TPP_enzyme_N Domain 2 165 172 139.0 9.8e-41 1 CL0254
+8FR_NODE_2#PROKKA_00239 305 430 304 432 PF00205.17 TPP_enzyme_M Domain 2 135 137 111.7 2e-32 1 CL0085
+8FR_NODE_2#PROKKA_00239 494 640 494 640 PF02775.16 TPP_enzyme_C Domain 1 153 153 115.2 1.9e-33 1 CL0254
+8FR_NODE_2#PROKKA_00242 7 67 6 67 PF03625.9 DUF302 Domain 2 65 65 53.7 1.1e-14 1 No_clan
+8FR_NODE_2#PROKKA_00245 12 77 12 80 PF04542.9 Sigma70_r2 Domain 1 68 71 43.6 1.6e-11 1 CL0123
+8FR_NODE_2#PROKKA_00245 123 175 122 175 PF08281.7 Sigma70_r4_2 Domain 2 54 54 32.7 3.7e-08 1 CL0123
+8FR_NODE_2#PROKKA_00246 3 386 3 386 PF00162.14 PGK Domain 1 384 384 518.4 7.7e-156 1 No_clan
+8FR_NODE_2#PROKKA_00247 10 355 8 360 PF00155.16 Aminotran_1_2 Domain 3 358 363 187.3 3.7e-55 1 CL0061
+8FR_NODE_2#PROKKA_00248 14 159 6 161 PF00795.17 CN_hydrolase Family 12 177 186 56.5 2.1e-15 1 No_clan
+8FR_NODE_2#PROKKA_00249 10 172 10 175 PF12804.2 NTP_transf_3 Domain 1 158 160 94.4 7.3e-27 1 CL0110
+8FR_NODE_2#PROKKA_00250 48 150 33 152 PF13185.1 GAF_2 Domain 23 141 148 30.3 4.9e-07 1 CL0161
+8FR_NODE_2#PROKKA_00251 20 317 8 335 PF00144.19 Beta-lactamase Domain 18 307 330 108.0 4.6e-31 1 CL0013
+8FR_NODE_2#PROKKA_00252 40 165 9 181 PF01209.13 Ubie_methyltran Family 37 161 233 71.4 5.7e-20 1 CL0063
+8FR_NODE_2#PROKKA_00253 2 78 1 78 PF01797.11 Y1_Tnp Family 44 121 121 85.1 3.2e-24 1 CL0481
+8FR_NODE_2#PROKKA_00254 1 115 1 115 PF02915.12 Rubrerythrin Domain 15 137 137 84.1 1e-23 1 CL0044
+8FR_NODE_2#PROKKA_00255 9 155 6 159 PF01613.13 Flavin_Reduct Domain 4 150 154 90.7 8.1e-26 1 CL0336
+8FR_NODE_2#PROKKA_00255 197 243 197 243 PF00301.15 Rubredoxin Domain 1 47 47 85.0 2.2e-24 1 CL0045
+8FR_NODE_2#PROKKA_00256 2 1029 2 1030 PF00873.14 ACR_tran Family 1 1020 1021 1080.8 0 1 CL0322
+8FR_NODE_2#PROKKA_00257 3 288 2 288 PF00529.15 HlyD Family 6 305 305 98.9 3.1e-28 1 CL0105
+8FR_NODE_2#PROKKA_00258 4 110 3 112 PF05635.6 23S_rRNA_IVP Family 2 108 110 98.1 2.6e-28 1 No_clan
+8FR_NODE_2#PROKKA_00259 42 233 42 233 PF02321.13 OEP Family 1 188 188 96.2 1.7e-27 1 CL0105
+8FR_NODE_2#PROKKA_00259 262 444 260 444 PF02321.13 OEP Family 8 188 188 91.6 4.4e-26 1 CL0105
+8FR_NODE_2#PROKKA_00260 1 240 1 241 PF03824.11 NicO Family 50 281 282 177.1 4.5e-52 1 CL0549
+8FR_NODE_2#PROKKA_00261 14 125 14 125 PF00072.19 Response_reg Domain 1 112 112 90.2 7.8e-26 1 CL0304
+8FR_NODE_2#PROKKA_00263 14 153 14 155 PF01242.14 PTPS Domain 1 121 123 105.0 1.9e-30 1 CL0334
+8FR_NODE_2#PROKKA_00264 61 134 58 134 PF03544.9 TonB_C Domain 4 79 79 35.2 1e-08 1 CL0428
+9FR_NODE_13#PROKKA_00266 76 162 75 162 PF04468.7 PSP1 Family 2 88 88 107.0 3.3e-31 1 No_clan
+9FR_NODE_13#PROKKA_00267 5 372 5 372 PF09334.6 tRNA-synt_1g Family 1 391 391 390.4 6.5e-117 1 CL0039
+9FR_NODE_13#PROKKA_00267 577 669 577 670 PF01588.15 tRNA_bind Domain 1 94 95 94.0 3.5e-27 1 CL0021
+9FR_NODE_13#PROKKA_00268 186 398 185 404 PF12695.2 Abhydrolase_5 Domain 2 137 145 54.1 1.3e-14 1 CL0028
+9FR_NODE_13#PROKKA_00269 67 105 67 105 PF00805.17 Pentapeptide Repeat 1 39 40 45.0 4.1e-12 1 CL0505
+9FR_NODE_13#PROKKA_00269 137 168 136 171 PF00805.17 Pentapeptide Repeat 6 37 40 44.0 8.7e-12 1 CL0505
+9FR_NODE_13#PROKKA_00269 303 357 289 359 PF07885.11 Ion_trans_2 Domain 23 77 79 42.6 3.4e-11 1 CL0030
+9FR_NODE_13#PROKKA_00270 27 246 27 247 PF12697.2 Abhydrolase_6 Domain 1 227 228 139.9 1.1e-40 1 CL0028
+9FR_NODE_13#PROKKA_00272 222 401 213 421 PF01435.13 Peptidase_M48 Family 31 189 226 44.0 1.8e-11 1 CL0126
+9FR_NODE_13#PROKKA_00272 474 530 469 534 PF13371.1 TPR_9 Repeat 12 68 73 21.2 0.00018 1 CL0020
+9FR_NODE_13#PROKKA_00272 564 595 563 596 PF07719.12 TPR_2 Repeat 2 33 34 17.0 0.0037 1 CL0020
+unf122_NODE_11#PROKKA_00276 1 64 1 64 PF06805.7 Lambda_tail_I Family 24 82 82 54.4 7.7e-15 1 CL0072
+unf122_NODE_11#PROKKA_00277 6 75 1 86 PF14464.1 Prok-JAB Family 29 96 105 39.7 2.7e-10 1 CL0366
+unf122_NODE_11#PROKKA_00277 88 200 88 201 PF00877.14 NLPC_P60 Family 1 104 105 51.5 6.9e-14 1 CL0125
+unf122_NODE_11#PROKKA_00278 29 230 29 230 PF05100.7 Phage_tail_L Family 1 206 206 324.2 2.1e-97 1 CL0249
+unf122_NODE_11#PROKKA_00279 1 109 1 109 PF05939.8 Phage_min_tail Family 1 109 109 127.7 1.6e-37 1 No_clan
+unf122_NODE_11#PROKKA_00280 50 257 49 258 PF06791.8 TMP_2 Family 2 209 210 224.4 1.1e-66 1 No_clan
+unf122_NODE_11#PROKKA_00280 626 703 626 703 PF09718.5 Tape_meas_lam_C Domain 1 78 78 72.5 1.8e-20 1 No_clan
+unf122_NODE_11#PROKKA_00281 11 113 11 113 PF06223.7 Phage_tail_T Family 1 103 103 173.9 8.1e-52 1 No_clan
+unf122_NODE_11#PROKKA_00282 1 125 1 126 PF06894.6 Phage_lambd_GpG Family 1 126 127 192.8 1.3e-57 1 No_clan
+unf122_NODE_11#PROKKA_00283 161 238 160 241 PF02368.13 Big_2 Family 2 76 79 44.8 8.2e-12 1 CL0159
+unf122_NODE_11#PROKKA_00284 1 131 1 131 PF06141.6 Phage_tail_U Family 1 133 133 210.9 5.1e-63 1 No_clan
+unf122_NODE_11#PROKKA_00285 3 192 3 192 PF06763.6 Minor_tail_Z Family 1 189 189 304.9 1.7e-91 1 CL0504
+unf122_NODE_11#PROKKA_00286 2 117 1 117 PF05354.6 Phage_attach Domain 2 117 117 207.3 3.1e-62 1 CL0504
+unf122_NODE_11#PROKKA_00287 2 129 2 129 PF14000.1 Packaging_FI Family 1 125 125 142.1 9.2e-42 1 No_clan
+unf122_NODE_11#PROKKA_00288 4 339 4 340 PF03864.10 Phage_cap_E Family 1 328 329 215.8 6.9e-64 1 No_clan
+unf122_NODE_11#PROKKA_00290 149 297 148 300 PF01343.13 Peptidase_S49 Family 2 151 154 158.6 9.5e-47 1 CL0127
+unf122_NODE_11#PROKKA_00291 30 401 29 401 PF05136.8 Phage_portal_2 Family 2 355 355 350.7 5.6e-105 1 No_clan
+unf122_NODE_11#PROKKA_00292 1 68 1 68 PF02831.10 gpW Family 1 68 68 125.4 4.3e-37 1 No_clan
+unf122_NODE_11#PROKKA_00293 39 600 39 607 PF05876.7 Terminase_GpA Family 1 547 557 592.4 6.8e-178 1 CL0023
+unf122_NODE_11#PROKKA_00294 1 164 1 164 PF07471.7 Phage_Nu1 Family 1 164 164 301.5 9.7e-91 1 No_clan
+unf163_NODE_15#PROKKA_00295 7 407 2 408 PF01053.15 Cys_Met_Meta_PP Domain 17 385 386 378.4 2.2e-113 1 CL0061
+unf163_NODE_15#PROKKA_00296 17 234 12 239 PF07690.11 MFS_1 Family 5 234 352 75.9 2.2e-21 1 CL0015
+unf163_NODE_15#PROKKA_00297 35 87 34 88 PF01381.17 HTH_3 Domain 2 54 55 34.7 1.1e-08 1 CL0123
+unf163_NODE_15#PROKKA_00298 219 463 217 465 PF00082.17 Peptidase_S8 Domain 3 277 282 129.0 1.8e-37 1 No_clan
+unf174_NODE_16#PROKKA_00301 1 195 1 196 PF00872.13 Transposase_mut Family 187 380 381 216.5 4e-64 1 CL0219
+unf174_NODE_16#PROKKA_00304 105 218 103 228 PF05140.9 ResB Family 143 260 464 26.7 1.9e-06 1 No_clan
+unf174_NODE_16#PROKKA_00305 113 255 86 260 PF01497.13 Peripla_BP_2 Domain 32 175 238 51.6 6.5e-14 1 CL0553
+unf185_NODE_17#PROKKA_00311 2 187 2 189 PF02305.12 Phage_F Domain 1 200 510 244.0 2.6e-72 1 No_clan
+unf185_NODE_17#PROKKA_00311 187 425 185 425 PF02305.12 Phage_F Domain 259 510 510 298.9 6e-89 1 No_clan
+unf185_NODE_17#PROKKA_00312 1 56 1 56 PF12283.3 Protein_K Family 1 56 56 111.5 1.2e-32 1 No_clan
+unf196_NODE_18#PROKKA_00317 48 104 33 106 PF07883.6 Cupin_2 Domain 16 69 71 34.7 8.5e-09 1 CL0029
+unf207_NODE_19#PROKKA_00320 23 231 21 234 PF02596.10 DUF169 Family 3 213 217 107.7 5.2e-31 1 No_clan
+unf207_NODE_19#PROKKA_00321 24 173 23 173 PF00005.22 ABC_tran Domain 2 137 137 112.1 2.2e-32 1 CL0023
+unf207_NODE_19#PROKKA_00322 8 245 8 247 PF12704.2 MacB_PCD Family 1 230 232 98.2 5.1e-28 1 No_clan
+unf207_NODE_19#PROKKA_00322 287 409 283 409 PF02687.16 FtsX Family 5 121 121 57.2 1.3e-15 1 CL0404
+unf218_NODE_20#PROKKA_00324 9 60 3 62 PF00571.23 CBS Domain 7 55 57 33.2 3.1e-08 1 No_clan
+unf218_NODE_20#PROKKA_00324 72 119 72 127 PF00571.23 CBS Domain 1 49 57 44.9 6.9e-12 1 No_clan
+unf218_NODE_20#PROKKA_00325 80 222 79 224 PF02518.21 HATPase_c Domain 2 109 111 62.4 2.8e-17 1 CL0025
+unf218_NODE_20#PROKKA_00325 279 448 279 449 PF00204.20 DNA_gyraseB Domain 1 172 173 146.6 4e-43 1 No_clan
+unf218_NODE_20#PROKKA_00325 476 587 476 588 PF01751.17 Toprim Family 1 99 100 85.5 1.9e-24 1 CL0413
+unf218_NODE_20#PROKKA_00325 618 690 617 690 PF00986.16 DNA_gyraseB_C Family 2 65 65 78.3 2.5e-22 1 No_clan
+unf240_NODE_22#PROKKA_00331 1 57 1 115 PF02203.10 TarH Domain 1 59 171 24.1 2.6e-05 1 CL0457
+unf240_NODE_22#PROKKA_00331 670 859 667 862 PF00015.16 MCPsignal Family 4 207 213 176.0 7.1e-52 1 No_clan
+unf240_NODE_22#PROKKA_00332 3 85 1 86 PF02596.10 DUF169 Family 135 215 217 55.4 5e-15 1 No_clan
+unf251_NODE_23#PROKKA_00333 19 156 15 160 PF01077.17 NIR_SIR Family 6 149 157 73.5 1.2e-20 1 No_clan
+unf251_NODE_23#PROKKA_00334 51 157 51 160 PF06073.7 DUF934 Family 1 107 110 133.1 3e-39 1 No_clan
+unf251_NODE_23#PROKKA_00335 53 221 52 222 PF01507.14 PAPS_reduct Family 2 173 174 122.2 1.9e-35 1 CL0039
+unf251_NODE_23#PROKKA_00336 20 100 19 100 PF03951.14 Gln-synt_N Domain 2 84 84 99.3 6.5e-29 1 No_clan
+unf251_NODE_23#PROKKA_00336 108 383 107 383 PF00120.19 Gln-synt_C Domain 2 259 259 338.4 2.1e-101 1 CL0286
+unf251_NODE_23#PROKKA_00337 17 65 5 65 PF00543.17 P-II Domain 54 102 102 62.9 3e-17 1 CL0089
+unf262_NODE_24#PROKKA_00338 4 151 2 151 PF00005.22 ABC_tran Domain 10 137 137 76.9 1.7e-21 1 CL0023
+unf262_NODE_24#PROKKA_00339 21 105 20 108 PF01895.14 PhoU Domain 2 85 88 67.6 9.2e-19 1 CL0297
+unf262_NODE_24#PROKKA_00339 125 208 123 208 PF01895.14 PhoU Domain 3 88 88 67.3 1.2e-18 1 CL0297
+unf262_NODE_24#PROKKA_00340 9 139 9 143 PF02915.12 Rubrerythrin Domain 1 133 137 61.3 1.2e-16 1 CL0044
+unf262_NODE_24#PROKKA_00341 11 186 11 186 PF13419.1 HAD_2 Family 1 176 176 69.8 3.2e-19 1 CL0137
+unf273_NODE_25#PROKKA_00343 40 324 39 325 PF02653.11 BPD_transp_2 Family 2 267 267 105.3 2.5e-30 1 CL0142
+unf273_NODE_25#PROKKA_00344 18 163 18 164 PF00005.22 ABC_tran Domain 1 136 137 111.3 4.2e-32 1 CL0023
+unf273_NODE_25#PROKKA_00345 91 113 91 113 PF12399.3 BCA_ABC_TP_C Family 1 23 23 31.0 1.4e-07 1 No_clan
+unf284_NODE_26#PROKKA_00346 2 80 1 89 PF04126.8 Cyclophil_like Family 34 111 120 75.9 1.8e-21 1 CL0475
+unf284_NODE_26#PROKKA_00347 5 112 4 115 PF02771.11 Acyl-CoA_dh_N Domain 2 110 113 71.9 5.8e-20 1 CL0544
+unf284_NODE_26#PROKKA_00347 120 171 120 171 PF02770.14 Acyl-CoA_dh_M Domain 1 52 52 68.0 3.6e-19 1 No_clan
+unf284_NODE_26#PROKKA_00347 227 379 227 380 PF00441.19 Acyl-CoA_dh_1 Domain 1 149 150 97.8 5.8e-28 1 CL0087
+unf284_NODE_26#PROKKA_00348 6 120 6 120 PF02771.11 Acyl-CoA_dh_N Domain 1 113 113 100.7 6.9e-29 1 CL0544
+unf284_NODE_26#PROKKA_00348 124 175 124 175 PF02770.14 Acyl-CoA_dh_M Domain 1 52 52 62.0 2.6e-17 1 No_clan
+unf284_NODE_26#PROKKA_00348 236 382 236 386 PF00441.19 Acyl-CoA_dh_1 Domain 1 146 150 150.2 4.3e-44 1 CL0087
+unf295_NODE_27#PROKKA_00349 145 330 143 331 PF00149.23 Metallophos Domain 29 198 200 25.8 5.8e-06 1 CL0163
+unf295_NODE_27#PROKKA_00350 48 121 24 122 PF07238.9 PilZ Domain 27 101 102 29.8 4.4e-07 1 No_clan
+unf295_NODE_27#PROKKA_00351 18 173 18 174 PF00300.17 His_Phos_1 Domain 1 157 158 116.5 1.1e-33 1 CL0071
+unf306_NODE_28#PROKKA_00352 23 143 23 144 PF13380.1 CoA_binding_2 Domain 1 115 116 126.7 4.5e-37 1 CL0063
+unf306_NODE_28#PROKKA_00353 23 261 20 262 PF00378.15 ECH Family 6 244 245 173.4 4.1e-51 1 CL0127
+unf306_NODE_28#PROKKA_00354 80 155 80 157 PF03061.17 4HBT Domain 1 77 79 54.7 7.7e-15 1 CL0050
+unf306_NODE_28#PROKKA_00355 13 128 12 144 PF01814.18 Hemerythrin Domain 2 131 133 48.4 9.7e-13 1 No_clan
+unf317_NODE_29#PROKKA_00356 16 156 11 160 PF12849.2 PBP_like_2 Family 104 277 281 84.4 8.9e-24 1 CL0177
+unf317_NODE_29#PROKKA_00357 113 313 109 316 PF00528.17 BPD_transp_1 Family 1 183 185 90.1 1.2e-25 1 CL0404
+unf317_NODE_29#PROKKA_00358 83 279 82 288 PF00528.17 BPD_transp_1 Family 2 175 185 77.9 6.5e-22 1 CL0404
+unf328_NODE_30#PROKKA_00359 21 98 20 105 PF00005.22 ABC_tran Domain 2 78 137 63.3 2.7e-17 1 CL0023
+unf328_NODE_30#PROKKA_00360 32 350 30 381 PF13458.1 Peripla_BP_6 Family 3 308 343 154.0 6.2e-45 1 CL0144
+unf328_NODE_30#PROKKA_00361 1 193 1 194 PF01266.19 DAO Domain 170 357 358 57.2 1.3e-15 1 CL0063
+unf339_NODE_31#PROKKA_00362 2 267 1 267 PF07592.6 DDE_Tnp_ISAZ013 Domain 46 311 311 409.3 6.7e-123 1 CL0219
+unf339_NODE_31#PROKKA_00364 12 221 9 249 PF00378.15 ECH Family 5 215 245 179.9 4.3e-53 1 CL0127
+unf350_NODE_32#PROKKA_00367 3 227 3 228 PF01370.16 Epimerase Family 1 235 236 137.7 3.9e-40 1 CL0063
+unf350_NODE_32#PROKKA_00369 25 104 5 105 PF01266.19 DAO Domain 279 357 358 56.4 2.1e-15 1 CL0063
+unf361_NODE_33#PROKKA_00371 108 224 64 238 PF01695.12 IstB_IS21 Family 48 162 178 54.1 1.2e-14 1 CL0023
+unf383_NODE_35#PROKKA_00375 12 72 10 72 PF00392.16 GntR Family 3 64 64 64.5 4.2e-18 1 CL0123
+unf383_NODE_35#PROKKA_00375 82 201 82 203 PF07729.7 FCD Domain 1 123 125 92.2 2.9e-26 1 CL0388
+unf866_NODE_7#PROKKA_00376 25 84 24 100 PF01926.18 MMR_HSR1 Family 2 57 116 56.4 2.5e-15 1 CL0023
+unf866_NODE_7#PROKKA_00377 5 219 2 221 PF01902.12 ATP_bind_4 Family 4 216 219 107.8 4.7e-31 1 CL0039
+unf866_NODE_7#PROKKA_00378 7 184 6 185 PF02737.13 3HCDH_N Domain 2 179 180 226.0 2.4e-67 1 CL0063
+unf866_NODE_7#PROKKA_00378 187 283 187 283 PF00725.17 3HCDH Domain 1 97 97 118.2 1.5e-34 1 CL0106
+unf866_NODE_7#PROKKA_00379 6 198 3 242 PF00753.22 Lactamase_B Domain 4 157 194 65.4 5.2e-18 1 CL0381
+unf866_NODE_7#PROKKA_00382 14 293 12 294 PF01180.16 DHO_dh Domain 3 293 295 240.8 1.4e-71 1 CL0036
+unf866_NODE_7#PROKKA_00383 36 254 36 257 PF02358.11 Trehalose_PPase Family 1 232 235 87.8 4.8e-25 1 CL0137
+unf866_NODE_7#PROKKA_00384 5 469 4 470 PF00982.16 Glyco_transf_20 Family 2 473 474 483.7 4.5e-145 1 CL0113
+unf866_NODE_7#PROKKA_00385 5 108 4 109 PF01740.16 STAS Domain 2 116 117 48.3 5.4e-13 1 CL0502
+unf866_NODE_7#PROKKA_00386 14 137 13 137 PF13581.1 HATPase_c_2 Domain 2 125 125 101.7 2.2e-29 1 CL0025
+unf866_NODE_7#PROKKA_00387 204 305 204 305 PF03448.12 MgtE_N Domain 1 102 102 89.0 2e-25 1 CL0436
+unf866_NODE_7#PROKKA_00387 311 365 307 368 PF00571.23 CBS Domain 5 54 57 16.9 0.004 1 No_clan
+unf866_NODE_7#PROKKA_00387 378 425 371 427 PF00571.23 CBS Domain 8 55 57 30.6 2e-07 1 No_clan
+unf866_NODE_7#PROKKA_00388 35 387 32 387 PF01566.13 Nramp Family 4 358 358 286.2 2.8e-85 1 CL0062
+unf866_NODE_7#PROKKA_00390 19 154 18 156 PF08327.6 AHSA1 Family 2 122 124 57.6 1.2e-15 1 CL0209
+unf866_NODE_7#PROKKA_00391 9 68 9 68 PF12840.2 HTH_20 Domain 1 61 61 59.1 2.7e-16 1 CL0123
+unf866_NODE_7#PROKKA_00393 12 427 10 427 PF00275.15 EPSP_synthase Family 3 419 419 342.8 1.9e-102 1 CL0290
+unf866_NODE_7#PROKKA_00394 11 236 9 236 PF13505.1 OMP_b-brl Domain 3 176 176 51.2 1.3e-13 1 CL0193
+unf866_NODE_7#PROKKA_00395 55 188 54 188 PF13492.1 GAF_3 Domain 2 129 129 64.5 9.6e-18 1 CL0161
+unf866_NODE_7#PROKKA_00395 217 352 217 352 PF13492.1 GAF_3 Domain 1 129 129 71.3 7.3e-20 1 CL0161
+unf866_NODE_7#PROKKA_00395 415 602 414 603 PF07228.7 SpoIIE Family 2 192 193 132.6 1.3e-38 1 CL0238
+unf866_NODE_7#PROKKA_00396 20 134 14 135 PF00156.22 Pribosyltran Domain 8 124 125 60.3 1.4e-16 1 CL0533
+unf866_NODE_7#PROKKA_00397 4 242 2 243 PF01790.13 LGT Family 5 255 256 151.8 1.6e-44 1 No_clan
+unf866_NODE_7#PROKKA_00399 51 235 51 236 PF01612.15 DNA_pol_A_exo1 Domain 1 175 176 111.4 3e-32 1 CL0219
+unf866_NODE_7#PROKKA_00399 267 646 265 646 PF00476.15 DNA_pol_A Family 3 383 383 431.2 2.5e-129 1 No_clan
+unf866_NODE_7#PROKKA_00400 9 383 9 384 PF01053.15 Cys_Met_Meta_PP Domain 1 385 386 438.0 1.8e-131 1 CL0061
+unf866_NODE_7#PROKKA_00401 253 312 233 312 PF13517.1 VCBS Repeat 1 61 61 34.1 2.6e-08 1 CL0186
+unf866_NODE_7#PROKKA_00402 41 209 38 209 PF02572.10 CobA_CobO_BtuR Family 4 172 172 136.4 6.9e-40 1 CL0023
+unf866_NODE_7#PROKKA_00403 78 252 71 256 PF13535.1 ATP-grasp_4 Domain 9 180 184 35.9 5.8e-09 1 CL0179
+unf866_NODE_7#PROKKA_00404 58 131 56 132 PF03061.17 4HBT Domain 3 78 79 38.8 7.3e-10 1 CL0050
diff -r 000000000000 -r 68a3648c7d91 pfam_search/f2
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/f2	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,3012 @@
+>10FR_NODE_6#PROKKA_00001
+MGDPKGFMTVPRKEASYRPRNERIYDFGEVEQTLNEEDRKLQTSRCMDCGVPFCHWGCPV
+GSKIPEWQDAYYRGNEEVAYEILHSTNSFPEITGRICPAPCEKSCVLSINEEPVTIRENE
+AANVENAFTQGWIKANPPSIRVV*
+
+>10FR_NODE_6#PROKKA_00002
+MEKKRKEMAFRFPKPDGLYNPANEHDNCGIGFVAHIKGEASHDIVERGLEVLRNLDHRGA
+KGSDNASGDGAGVMVQIPHEFIKKVLKIDVPAKGSYGTGLIFLPQLEAEANACVDILSNI
+IQEEGLQLIGYRDVPTDSSIPGEIARTTEPRIKQVFIKANLEEDILEQKLYIVRKRAEKA
+VQASDLSQKEVYYHSSLSAKTMIYKGMLTPDQMKDYFTDLQHPLFKSALILIHSRFSTNT
+FPTWDLAQPFRLVAHNGEINTIKGNRLWTQAREGLLKSEVFGDDLPKILPVLEEGKSDSA
+SFDNVLEFLHRTGRSLHHSLCMMIPESFNEKNPIPESLKAFYEYHSTIMEPWDGPASIVF
+SDGRYIGGTLDRNGLRPSRYVITKNDLIVMASETGVQDFAAEEILEKGRLRPGKILLVDT
+RLGIIIPDEEVKEQLSRRNPYGMWLKENRLLMEDIKVRQRVPSTMDDFLTYAKVFSYSKE
+DMEFLIQSMSNTAVEPINSMGNDTPAAIFSRQPQRLFNYFKQTFAQVTNPPIDAIREGLV
+MSLTNYIGSLNSNILKESPDHCKLIKFPDPIVTNTDLGKIKDLKDEMFSHEIISIVFPVD
+QGFEGFKKAFDEMLERAEKAVDDKKNFIILSDRAIDSKHAPFPSLLAVSAVHHHLIQKKK
+RMQVGIAVETGEAREVNHYALLLGYGASVINPYLAFAAVDHLVKEGKLDMEYKDARRNYI
+KSIKKGLLKIFSKMGISTVRSYHGAQIFGAFGLSKELVDKYFKGTSSPISGIGLEEIYEE
+YSQFHKDAFREEATQEKFRFETTGVYAWRKNREDHAWNPDSIGLLQWATRTNSYEKFKEY
+SRTVDEYNRKPSFIRGCFQVKRNSISIEEVEPVEEIMKRFVTGAMSYGSISKEAHESLAV
+AMNTVGGRSNTGEGGEDHNRFGTEKQSAIKQIASGRFGVTSNYLTNAREIQIKIAQGAKP
+GEGGQLPGYKVNEVIAKLRNSTPGITLISPPPHHDIYSIEDLAELIYDLKATNPKAKISV
+KLVSQDGVGTVAAGVAKAFADLIIISGGEGGTGASPISSIKHAGLPVEIGIAEAQQTLVK
+NNLRGRVKIQVDGQLKNGHDIVTMACLGAEEFGFATSALITLGCVMMRKCHLNTCPTGIA
+TQDETLRERFTGNPQLVINFFRFLAGEVRELLAEMGFKKFDDIIGRADLLEENKEVFGWK
+MKNVDFSAVLNRPAEADKFDIRYVPGSASLNLDGHLDHTLIEESGKAIKGKEKVWLHHPF
+ANTDRAIGAMLSGVISQKYGEFGLPEDTIHATFDGSAGQSFGAFLAKGVTFRLEGDSNDY
+IGKGLSGGKIIVVPPTGSTFTPEENIIIGNSTFYGATGGEAYIQGVAGERFCVRNSGMEA
+VIEGAGDHCCEYMTGGRVVVLGKTGRNFAAGMSGGIAYVLDEDGDFDFYCNKGLVELLEV
+EDKKDIKELQGLISKHLTYTQSPKAAKILTQWEEYLPKFVKVIPYEYRKVLRERELRELE
+QKMKMTEDANVMQE*
+
+>10FR_NODE_6#PROKKA_00003
+MLEQKELILLNISGEDKPGLTASLTEILSQHNVNILDIGQSVIHKDLGLGILFEVPKKYR
+SASILKDLLFKAYELKSHIKFTPIPIEEYEKWVAEQGKERFIITLLAHKLTALHLSKVSS
+LIASQKLNIDTISRLSGRKSLNGNNKVTNSVVEFSVRGTPLDINAMKQSLMNIASETGID
+IAFQEDNIYRRSRRLVCFDMDSTLIQTEVIDELAQKAGVGDEVKKITESAMRGEIDFKES
+FKKRVSLLKGLDESVMKGIAENLPITNGAERLLSTLKQYGYRTAILSGGFTYFGNYLKTK
+LGFDYVFANELEIKNGKLTGKHLHEIVDGKRKAELLELLAFKEDIHLEQVIAVGDGANDL
+PMLEKAGLGIAFHAKPKVKASAQHAISATGLDTILYLLGFRDREINAS*
+
+>10FR_NODE_6#PROKKA_00004
+MLIQEASKWDIITYVLDNDETCPANSLATHFVKGSNLDFDSVYRFGKMVDLLTYEMENIN
+IEALKKLKSEGHQIIPDPDILELIQDKGKQKEFYQDNNVPTAPFKIYSSRQDIVQAIKNG
+EIKFPFVQKLRTGGYDGRGVAVISDENDLDKLLDGASIIEDKVNIAKEIAVIAARNKQGE
+IKCFPVVEMVFDPEANLVDKLICPSKITAEQSEKAIEIAGKIIGLLGMQGLLAVEFFVDE
+NGEVIVNESAPRPHNSGHHTIESIITSQFEQHLRAIFNLPLGSTRPKLPAVMVNILGGEG
+YEGPVRYEGLTEIMAIEGVKIHLYGKKITRPFRKMGHITVLSDSLETALEKAEKVKQLIK
+VKSWDKN*
+
+>10FR_NODE_6#PROKKA_00005
+VGQKLVSIVMGSDSDLPVMKPAAEMLEQLGVEYEIDIVSAHRTPEKLFDFASNAHKRGIQ
+VIIAGAGGAAHLPGMVASMSPLPVIGVPVKSSNSIDGWDSVLSILQMPGGVPVATVALNG
+AKNAGILAAQIISVSDSQVREKIIEYKAGLKEAVMKKAKNLKG*
+
+>10FR_NODE_6#PROKKA_00006
+MDPKTVIRELLTGTGVHLNGPHPYDVQVHDERAYERWLSEAELGLGESYMDGWWDCLALD
+EFIERILRAGLEEKVKRNFSTAFYVLSKRLFNQQTRVKSKRVGREHYDLGNELFSKMLDR
+RMVYSCGYWQRAKNIDQAQEAKLDLICKKLNLKPGMKVLDIGCGWGSFAKYAAEKYGVEV
+LGVSISKRQIELGNELCKGLPVTLLYKDYRDVEGKFDAVVSVGFFEHVGYKNYDTYMKIV
+DRCLTDNGISLLHTIGNNTTTHYVNRWTNKYIFPNGMLPSIAQVAKAAEPYFVIEDFHNF
+GPDYDKTLMAWYDRFNKAWKELKNQYDERFYRMWRYYLLSSAGGFRSRATQLWQFVMTRT
+GRQQPDCRFA*
+
+>10FR_NODE_6#PROKKA_00007
+VAHAATTGNNETLLCRFPTLHNNTIVFEAGGNLWRVDRTGGVATRLTTDPGYDMMPRFSP
+DGKTIAFTGQYSGNVDVYTIPADGGAVTRLTYHSDVVRKAPTRWGPDNMVMTWTPNGKDI
+VFLSRRDTWNSWFGQPFEVSKMGGLPTHLPLPKGGVMSYSPDGSKIAYNRIFRNFRTWKR
+YKGGLAQDIWIYDFKTKKIQRVTKWKGTDTYPMWYKNTIYFASDRGANHRLNIWAYSLDT
+KTFRQITHFKNYDVDWPSLGNNGIVFQDGGSLYVLDLPSEQLHKINVKVPTDGTQTLPRW
+INASKMIRSLDISPNGKRVLFGARGDIFTVPAKHGATRDITQTSDAQEQYPAWSPNGKWI
+AYLTDASGVNELAIRPSDGSGHQTYITNAKTGYYYNPTWSPNSQMLAYSDNNHVLWYISL
+KDKKPVRIAQDKYNAMRDYHWSPDNNWISYSKTNASGLSQIYIYSLADHKSYKVSDGIYS
+DNDPVFGPNGKYLFFVSARHENPLFSESESNVATEKMDGIYMVTLQKNEKSPFAPVSDEG
+MPEAKKASSSASKKTESAKDVKIDFNGLMNRVIMLPIKSGDYGNIQVTGNKVFYQTRPLI
+TIEGFLHGTGQSSIMVYDLKSKKGHTVVANGARTYGLSADGKTLVYMRRGKFFLMPSASV
+NAKGSEPVNTSHMKMKIYPHQEWSEMFHQAWRLFNNFFYNTKMNGVNWNEVGANYGKLVP
+LLGCREDVNYLVGEMIGELDNSHCYVWGGDDNYLGKTNPTGVLGVDFGLNKSSGRYYFKK
+IYAGDNSRPGYGSPLDRPGVNVKTGDYLLAVNGHQLKAPMNPYSLFVNTVGQQTTLTLAD
+KPDGKGEHTVTVKPINNSLNLRLLNWIRTKRAYVNKKSDGKIGYIYMSDMESLGMTQFIH
+QFYPQLSKQGLIMDDRFNGGGFIDQIVLERLRRVLIGMSTNRAHAAMRYPEQVLHGYKAC
+LLNHYSASDGDMFPFYFRKYGLGPLIGERTWGGVRGYNRVWTLLDGGNLVVSQNSIYGLD
+SKWAIENHGVTPDIKVDNLPGQVMEGKDPQLDTAINYIMKKLKEHPMPIPQPPAEIPAYP
+SGNDAGGTN*
+
+>10FR_NODE_6#PROKKA_00008
+MIRYNLHQHSIFSDGAAEPEAYVQSALNLGFEAMGFSEHSPLPFPTKFSLKAERVEDYIR
+ETERLKEKYNDRIDLYRALEMDFIPGYSENFTEWRKKAQLDYAIGSVHMVQPEDDGELWF
+IDGPDRSIYDDGLQNFFGGDIKKAVKTYFHQVNRMVETQDFEVVGHVDKIKMHNQNRYFT
+EEEKWYRDLVEETLHLIKEKDFIVEVNTRGLYKKRSNRLFPDDYALQRISELGIPVLISS
+DAHKPEELNLLFETAEKRLLDMGLGAVVRFDHGKWKDFPLS*
+
+>10FR_NODE_6#PROKKA_00009
+MIDAAKRASARKIVAVIPYFGYARQDRKDKPRVSIGAKMIANLLTTTGIDRLITMDLHAD
+QIQGFMDFPVDNLYASVIFYPYLKKLNLPNLMMASPDTGGTRRAANYAKALDTGFVICYK
+QRTRPNVVEQIQLIGDVAGKDVVLVDDIIDTAGTITKAARVILDKGANSVRAMVTHPILS
+GDAFKIIADSPFTEVVVTDTIPVKDDLGGKIKVLSTAQLFSEVIKRVENYKSISSLFNLG
+NQSNK*
+
+>10FR_NODE_6#PROKKA_00010
+MNTVSLSGSLRENVGKKDAKKQRRLGKVPCVIYGGSEQKHFTLDQLEFKPLVFTPEASVV
+NLTLGEKTYECILQDVQYHPVTDEILHADFLEIHSEKPVNIALPVELTGTAPGVVKGGKL
+RLKMRKLRVNGIIKLMPEHIVLDISKLDIGRSIKVRDINQANLTFLDPGNQVVVAVVAAR
+GLSAEEEAEEAEEGEEGEAAEGGEEGGEKSAE*
+
+>10FR_NODE_6#PROKKA_00011
+MKYLIAGLGNIGVEYANTRHNIGFIVADALVNELKGKFETERLASVASVKHKGRTLVVIK
+PTTYMNLSGKAIKYWIDKEKIPIERVLIVVDDIALPLGTLRMRKKGGAAGHNGLSDIIMK
+LGTEKFPRLRVGIGDDFAKGYQVDFVLGQWTDKEVNVMIPRVQKAVEIVQSFVSAGIDNT
+MNLYNNK*
+
+>10FR_NODE_6#PROKKA_00012
+VFQGKHQLNVFINILTQIKTMLRIRNFNNFVSNFLKIFAKFYNQAKIISYRLIILLQASV
+TGQPNHSIEMEKQRQQSGLLFKIK*
+
+>10FR_NODE_6#PROKKA_00013
+MAVEAVRGLLEKTGTKPEEVDLVICATVTPDMQFPATANLVSYKLGINNAFSFDMNAACS
+TFIYALITGSKYVESGEYKKVIVIGADKMSSIVDYTDRATCVIFGDGAGAVMLEPTASDE
+PGIMDHRFYTDGAGWIHLHQKAGGSLKPASHATVDAKEHFIYQEGQPVFKFAVTRMADVA
+AEIMERNQLKSEDIAWLVPHQANLRIIDATARRMGVSKDQVMINIQRFGNTTNGTIPLCL
+YEWEPQLKKGDNIVLAAFGGGFTWGSVYLKWAYDGKK*
+
+>10FR_NODE_6#PROKKA_00014
+MHYNPNAFALSLRNSYSKIIGLIIPEITLYAFPSMIRGVSEFCYNAGYNVLILSSNESYK
+REVQNTELMLSSQVDGLLVAITKETRNHKHFDQLEKEGIPVVFFDRVFNNYGTSKVIIDD
+RRAAYEATEHLIKTGRKNIAYFGGNAALYITQQRLMGFRKALSDYNLEEHDLVFADDSHM
+ARNKALQIFKRKNYPDGIMSISDEVLTGIIPALQELNIKIPNEVGVISFSDGPISQMYKP
+AISIVHHSLARVGQVAVDLLIQRIEHPEDMHQQIHIIDTELIARGSTAIGK*
+
+>10FR_NODE_6#PROKKA_00015
+MKKVVQAFMVLLALTITTGLMAQGTIKGTLKTTKGKTVPGVNILLKGTTTGTTSSLNGSF
+VLKVPAGKHVLLVSFTGFKPINYSFTIKDGETLTKNFVLHEDLLALDQVVVTGVQNKQTK
+LQSSVAITTLSPQKISQIAPRSAADLLKAIPGFYVESSGGKGNANVFARGLPSSGGLRYV
+QFQEDGMPVFEYGDLMFGNTDIMVRIDQTMSRMEAVRGGSASVLTSDAPGGIINIISKTG
+GPTTKGVFMQTIGLTYMHARTDFDIGGPVSKHLRYNIGGFYRADNGIRSPGFLANNGGQI
+KANFTYTFNKGYVRFRTKILNDKTIAYLPFPMMGNPAKSIPGFNANYGTMKSLDLLHLHA
+TTPTGNSVNESLADGMHPKIFAFGGEAFFDLGNKWSLKDNFEKTFTHIQFNSIFGVNAPE
+SASAYATAQGLTNYHYAFADGYNAGKPITNMSSLNGNGLVATYGWWSVGLNLQEFGNDFK
+LTKQSTNNTFTAGWYFSTNQVGGNWWWHNMLVDISGHNTRKLNLINDNTGESLTTNGYSQ
+YGTLYADYNALTVINAPYVYDEIDLGRLTINAGLRWDMGTITGRVENTGSYSYDVNGDGI
+ISPAEKNIQYGNGTYTPFHYDYSVLSYSLGLNYEFNKSTAIFARASQGHRSPADRAYVFG
+ATTSTPNGFPSSAKDESIEQYELGLKYNSSKVALFATGFYSFFNHIDFTDFVNVGGNLTA
+IQQYYNTSAMGLELEAAAQLGKLNLSLTGTAQSAKYHNWVYHDQSGNLHDFNNHFIQRLP
+KLYFTFRPSYNFGKLNVSAAWEYFGKRYTNPENKQVLPQFSQINAYIDYTVSPHITISAA
+GNNLFNVIGLTEGNPRSGLVSTGGSQYFYARSILGRSAILSFKYSF*
+
+>10FR_NODE_6#PROKKA_00016
+VKHIDISPIDIAIIVIYIVGIAVWGLMYSKKKSKGKGHEGYFLAGRNMTWPIVGITLYAA
+NMGSPALVGLAGDAYSTGISVFNYEWMALVVLVFFAIFFLPFYLRSRVYTMPEFLQRRFD
+IRSRYYFSFITLVGNIIIDTAGVLFSGALIVKMIFPAMALWHIIAVLAIITAAYTITGGL
+SAVMYTEAVQGVLLMLGAVLLTFFALKRIDFNVARIFTETPHHMMSLIRPNSDKAMPWLG
+LVLGVPLLGFYFWGTNQFMVQRVLSAKNTNHGRWGALFAGILKLPGLFIVVLPGIIGRLI
+FPHLSDPDLIYPMMLFHLLPVGILGIVLAGLIAAISSSISATLNSASTLMTMDFVNNLKP
+GLTPKQLVRIGQIFTGVFVVISAAWAPMIAGFPSLFKYLQQVLALISPPVVAVFLLGLFW
+KRANAQGAFYGLMGGLLMTIFAVIVRYVNPDIFPWLGHIQFLLVAPVLLVGTMAIIVPVS
+LMTPPPPEEAVAQFTWSFKFFNAESMELAGTPWYKNYRYQAIGALLATAILVYIFR*
+
+>10FR_NODE_6#PROKKA_00017
+MEEAKNTYSKALDLLKNGLLKEGFVAALDQQANYRRVWARDSIITGLSALLADDTTLIEG
+MKKTLISLKQHQHANGMIPSNVSFDADGNVTMVSYGTLTGKVDTNLWFIIGVMVYVRKTS
+DTDLLKEMLPAIEKVFELLLSWEFNGRGLLYVPQGGNWADEFILEGYNLSEQLLYYWALS
+EASAMDEKFSTKAKKLKDLIEINYWPTESNRSKVYHKTAFERQLEKGQTSHWLPGFKPAG
+YHTFFDCFAHGLSFVLQFNSPEQEGEIIETLVRTTSETSGSLLPSFWPPVRETDAQWETL
+QTNWIYKFRNQPGAYQNGGIWPISNGLLIAGLYRSGHKGMADKMKEALFLATALPENQFG
+FYEYIDAFSWEPGGAKHQLWSAAGVIFAEKAAQNVFIV*
+
+>10FR_NODE_6#PROKKA_00018
+MEGDIINLNDEHRSTARKIVAPLIEEIKNCQTIYTFSVAGESGAGKSITAAAIAEQLELA
+GFSVKVFQQDDYFFLPPFTNDQKRRKDLEWVGIKEVDLALIDEHLKAAKDGVKTIKKPLV
+IYGKNKITSEVFDMKGVNVCIAEGTYTSLLKNVDKRIFIDRDFFDTHNDRKKRGRDLIDP
+FTEKVLEIVQCS*
+
+>10FR_NODE_6#PROKKA_00019
+MEAITNGMMNLNRQRHQHLVALRIIFAHGENGGEEVVHIGHVAIKTGDTFPGTGRVDLLC
+LTHCLTSTD*
+
+>11FR_NODE_14#PROKKA_00020
+MFKVMIRDSMSPVAREILTATGKIEVVTDNDKAANAPEVLAEMIGEFDGLAIRSGTQVTR
+AVMEKAGRLKIIGRAGIGVDNIDLEAATRQGIVVMNAPGGNTVTTAEHTVSMMMALARNI
+PQATASLREGAWDKKKLIGVEIAGKTLGIIGLGHVGRIVADRARGLKMRVIAADPYVSCD
+AAARINVRLVSLDELFSASDFISLHVPRLKETVNMINADTLSRMKPGVRIINCSRGDVVN
+VDDLYRALESGRVAGAAIDVFPKEPPDASLPLLKHPRVVLSPHIGASTGEAQVKVARMIA
+EQMAACLIDGVITNAVNFPSVSMEEMARVV*
+
+>11FR_NODE_14#PROKKA_00021
+MNDPIYQKLATVLDTLPNGFPATEDGKEIRLLKKIFSPEEAELFCDLKLTFETAEQIANR
+TARPVEELKARLSVMQEKGQIFGIDMGGVGIYKMLPWAFGIYEFQLPHMDRELAELCEQY
+GKTYGKQFFANKPQLMQVVPIESEIKAEHEALPYERVSTIIENSRSFMYFDCICKKEKGL
+MDEPCDKPVQVCTAFAPIPGVFDDHPYGKTMTKEEAYQLLNKAEEAGLVHLTWNVKSGHF
+FICNCCGCCCGVLRGINELGIDASKVINSYYYAQIDAEACVACGTCADERCQVNAIMEGD
+DAYTVIAEKCIGCGLCITTCPGDAISLVRKPAAQIETPPDDEMDWYEKRAQLRGVDISDY
+K*
+
+>11FR_NODE_14#PROKKA_00022
+MELTNDEREFFALVNRASLLNPFSDERNDVDLKLAGLPSAAPGTGRVKKAIQSVNERIRQ
+LETDGRADISQYTGRDRELVEKAFLFELFYRFRKQFDELIESQIASDDVPARIPFYNDAF
+SAMQKRGFTEEDFRRYFALAFQIRRAFYFIGRSLVGNSASMKSLRLNLWNNVFTHNMDLY
+DRYLWNRMEDYSTLILGETGTGKGAAALAIGRSGFIPLKKKSFEESFTRSFISLNLSQFP
+ETLIESALFGHKKGAFTGAIENYQGIFEQCSPYGAILLDEIGEVSKPIQIKLLQVIQDRV
+FTPVGSQTRSRFNGRVIAATNRPLETLRGKGFFRDDFYYRLCSDIIVVPPLRQRVQEDPT
+ELDVLLDFTINRLVGRSSPELVQIVREVIDRHLGNDYPWPGNVRELEQCVRRVLLKGIYT
+GDAAVADIDLCRSLTTGIEQGNIDANSLTSGYCYLLYQRHRTFEEVARRTGLDRRTVKKY
+IQDWTSSHSTDNPPETDIPG*
+
+>11FR_NODE_14#PROKKA_00023
+MKIQQIIIREFEEMMAELKEVLAKMTCPLLGEDWLPM*
+
+>11FR_NODE_14#PROKKA_00024
+MAVDKNEFFRQATIRICGSLDIETALERCFHYLEQMLPVDEIGLYLYDPGLNVFQRIAGV
+KSHGKNEFSPVSPLPEASKEKWSAIWADMGDITIINRVEERPEIQEVIEMYGLEHDISLM
+SMRLELEGKRVGLLLLRTRGRDRYEEKHARLMLLLHEPFAIAMTNALQHQELIRLKDILT
+DDNRYLRRQIRDLSISEIVGADLGLRHVMEMVQQVTQLDSPVLLLGETGVGKGVVAHAIH
+DASPRKNAPFVSVNCGAIPESLFDSELFGHEKGAFTGAIAQKKGRFERADKGTIFLDEIG
+ELPPHAQVRLLHVFQEKIIERVGGTTPISVDVRIISATHRNLEEMIRSGKFREDLWFRLN
+VFPIHIPPLRQRKEDIPALVHHFIEKKTIDLKMQEQPRLSPGAMDQLMAYDWPGNVRELE
+NIVERALIQFKGGMLRFDGLIFSPIASSRGGGHETTDRFLSIDEVNAIHIRRALKVTNGK
+INGPGGAAELLGINPNTLRKRMNKLNIPYKKKEIGQGVD*
+
+>11FR_NODE_14#PROKKA_00025
+MRFKTLKYILVPVLAIGLSGCASTLTLLSPPSSRLVQGKNTAGAFNSYEYQYAVRGNKIY
+IKRTPLCDEVKHVMRVEQKREIGYGPALLELPLFGLGLVDIANAHAISVNSKKVTPLADY
+NTGKLMACGPLQPAANEKVIIENKNLNLYRMVRTDKNGVVNLDKVLSGIGNNVNLSVRLA
+NNHNVAFSCMYIANR*
+
+>12FR_NODE_3#PROKKA_00026
+MSAQAAPFAVLSDIATRSRSQSRGLPAQEEAVELWNGIGFSLAGQLYVAPMGEVVEILHL
+PRYTQVPGVRAFMVGVSNVRGRLLPLVDLGLFLDFPRSVV*
+
+>12FR_NODE_3#PROKKA_00027
+MARILIVDDSPTEVKKISSLLEKHNHEVLTADNGADGVAKARAESPDLVLMDVVMPGLNG
+FQATRQLTRSPDTADIPVVIVTTKDQETDRVWGTRQGAKGYLVKPVKEDELIKTIDDLLA
+*
+
+>12FR_NODE_3#PROKKA_00028
+MEDNFENLKIMVIDDSKTIRRTAETLLKKVGCEVITATDGFDALAKIADSHPDIIFVDIM
+MPRLDGYQTCALIKNNSAFKSTPVIMLSSKDGLFDKAKGRIVGSDQYLTKPFSKDELLNT
+IRQHIPSREST*
+
+>12FR_NODE_3#PROKKA_00029
+MSVKLGIVMDPIGAIHYKKDTSLAMLLAAQRRGWELHYMEMQDLYLRDGEPRARTQALTV
+AANPDDWYSLGEPSDRALASLDVILMRKDPPVDKEFLVTTWMLEAAERLGTLVVNPPQAL
+RDCNEKLFATWFPQCTPPLVVSRDAARLRAFHAEHGDVVLKPLDEMGGRSIFRVREDGDN
+LGVIIETLTKDGSHQIMAQKYLPEITQGDKRILLVDGEPVPYALARIPSQGEHRGNLAAG
+GRGEGRLLTDRDRWIVEQVQPMVREKGLLFVGLDVIGDYLTEINVTSPTCVRELDREYDL
+DISDQLMQVIADRLARR*
+
+>12FR_NODE_3#PROKKA_00030
+MAASAVRVSDTDRLTFTLFLALVLHAIVVLGVTFTAHKPQPSARTLDITLAQRDDQKAPK
+HADYLAQTNQKGSGTLSKKAQITTRHRAPINASQVHKVKPIPRSQPQHSQAKPEKRHVVT
+TVSQQATQQVDSDDKEQKAHQKHNHKSLMSRALEIASLEAKLDQETQRYAKRPRVLRVTA
+ASTLKSTDAWYVQAWVNKVTRIGNLNYPEAARRRGIHGTLRLLVDILPNGHVKDIQVLQS
+SGYKVLDQAAMRIVRLAAPFAPFPPELRKRKDVLEIIRDWSFEPRGLSTNG*
+
+>12FR_NODE_3#PROKKA_00031
+MSEANPYIRNQFLIAMPYMQDPNFNGTLTYICDHNDQGALGLVVNRPLDFSLGEILEQLD
+IECGHLDVPVYSGGPVKVERGFVLHRSRGEWQSTLEISGDLSVTTSRDVLEAIAEETGPE
+DYLVALGYAGWGAGQLEQELAGNFWLTCPADPDILFNVPWQQRLPAALARLGIDWSQLSD
+SVGHA*
+
+>12FR_NODE_3#PROKKA_00032
+MPDLKPEGQRQVMAFDFGLRRIGVAVGQEMLGTASPVTMIGARDGIPRWDEVEALIADWK
+PDFFVVGLPLNMDGSESEMCRRARKFARRLHGMYHRDYAMMDERLTSFAAKSAIVEREGG
+RDFGVKGVDDLAAVLILEGWFLQQRDQQPKIPTP*
+
+>12FR_NODE_3#PROKKA_00033
+MTAQINVERLLETMCSQLEQTLEARGAVNPVLTGIRTGGVWLADYLHKRLRLEEPLGELD
+ISFYRDDFSRIGLNPRVKPSNLPFATEDRHIILVDDVIMSGRTIRAAMNELFDYGRPASI
+ILVTLLDLGARELPIQPDIVGQQMQLQRDQRVKLMGPDPLRVELRENVRENPAKDASTKS
+H*
+
+>12FR_NODE_3#PROKKA_00034
+MIDTCEAARQLQLNAAGSLRHFLTLDGLDRPLLTEILDTADSFIEVGERRIKKVPLLRGR
+TVVNLFFEASTRTRSTFELAAKRLSADVLNLNISTSAASKGESLSDTLLNLEAMASDMFV
+VRHAQSGAPHFIARHVTPGVGIVNAGDGRHAHPTQAMLDMLTIRQHKGGFEGRVVAIVGD
+ILHSRVARSQIRALEILGADEIRVIGPNTLLPRDVESLGVKVFNDMQRGLKDVDVVIMLR
+LQNERMEGALLPGEREFYRLYGLTTEKLRYAKPDAIVMHPGPINRGVEIESAVADSPRSV
+ILNQVTNGIAVRMAVMSMVMSGQLAQLNQGDAAQEQSRTL*
+
+>12FR_NODE_3#PROKKA_00035
+MKLLIQNGQLLDSRTGQVRSGAVLIEDQKIVAVGEQVLDQAADRVFDADGAWISPGFIDL
+CCFVREPGDDQKGTLASETRAAAHGGFTTVCASPESSPVNDSGAVTTLILERARKQGCVR
+VLPVGALTRGLQGELLSDMASLARAGCVALSNGSLSRGNARVLRRCMAYAKTFGLTLFMR
+PENPDLAADGYAHEGVVATRLGLPGIPEIAETIAVGELIQLAEDTGVRLHLSQLSAARSV
+ALLRSARERGVPVTADVAIQQLAFNEGWLADFDSRFHCRPPLRTEADRQGLLAAVNEGWI
+DAIVSQHQPHDPAAKQAPFGETEPGLSTVESLLGLGLKLVNAGELELPRFLQALTLGPAQ
+VLNLPEPRLEAGSRADLTLFNPNGQWIPAPETLLSAGKHAPVLDQPLPGRVMLTLSRGKV
+AYADPQTEFGL*
+
+>12FR_NODE_3#PROKKA_00036
+MSFLIFVALLVALWLLWTISRNTADALDKQTAVQYEIIALEKRMEELSEALKAQSGETAK
+PARRSSSSRSKKEDEKEKKEGE*
+
+>12FR_NODE_3#PROKKA_00037
+LENSTQNALHKPELAGKIADQTQLTRAQAHEVITAFTDQVSAAMARGETVALAGFGSFNV
+RERQARTGRNPRTGEALQIPAHKTVGFRPGKAFREAIE*
+
+>12FR_NODE_3#PROKKA_00038
+MRWLSHSAFLFSHGRSAVKALSLLLLFSLGGCSAVNNMMYKTTGEVMVGYAKAHAVPYVL
+SSDDLGMSCAMSEALTPLLMSFGQVTAKPDQLGVMMQMSAGTCAEEKGWNAELAYMKELR
+NQHPQNAEDDMIVEKRHYIEAADRYYSAWKHLVAYYGDPSTGQCPTFKNDEGQFIYMAGL
+LAGVQALAAEIQSTSDEGVPKNIGSTVAQASGCLSDDKWWGVPMALRATVWSMIPGAKPD
+GENPFQRLDESDKKANKARVRLAYVLHVIAAWNKGDTKLVKKLIREQQAQEAKYPADPRW
+KMIDKLSTLYLRSISDRMWVEHTGHRTPIGGLGTFWDDSKGSGEVIDLDSVM*
+
+>12FR_NODE_3#PROKKA_00039
+VKPSGKRFSLKTWSLASLTLAGMLALQPAANAGSLPKRSFCVFDPVGANGPLFNLMKSTK
+PAALDWGVDLQMRAYTDEKIAAEDFKGGQCDSVLLTGTRAREFNKFTGTLEALGAITSNK
+EERVLMDTLNQPKAAKLLTNGDYEVAGILPAGAVYLFTRNRNIDTVNKLQGKKIATLSYD
+RASLTMVRHVGASVVGASSASFAGLFNNGSVDLAYAPAVAYTPLELYKGLSHDGGVLQYP
+LAQMNFQIILHKSRFPKGYANHVREYAREHLNQAFSIINKATDEIKKKYWMYPTDKQTAS
+YDQMLQSVRLSLRDKGVYDAKALKLMKIIRCKVQPSRGECSQNAE*
+
+>12FR_NODE_3#PROKKA_00040
+MSEAIEQSSMYLQKRTIGGRSAREWFSSLPACILLMAVVLFTTSSDIHNKALQLGQVLWS
+GYYKLRVDPVKPDCNPNVNVDAQVKRQIAAQAAQQDSMLGSLVGSSPVNPAAVRQSVINA
+KQACEAQFADYNATKGRITEGVRVYRSVELFISDVVAFGLASQRYILALLVLVCAATATF
+SRHHIAMRGMETRLDHIVSHFMQFIANTMLLISSFMYRQMSHNSGAVVTTGQEISHDIWI
+AGFLLLTIVSLVQLFRVPEDAEEGGTLGHAFLCVPLYTTMCLISGTFFAFVGSPAGIGIY
+LDKMMELADQFLNVGLYVWAGMMLKQTRLASLVFNVLRPLKLPPELLAVVAVMVAAVPTA
+YTGASGIFVIAAGAVIYSEMRKAGARRQLALASTAMSGSLGVVLNPCLLVVVIAYLNREV
+TTDSLFHWGGWVFLLTSTLFLITSLVVNRQKGFKVAPMNEALPEMVMRLKPLIPYVLVIA
+GVVFFYWLLLGVTMNEFSAPRILPIIMVGILVYEHVHFRGDRNKVSGEVDHQGLEKSLRT
+ATSETTAEIGALLLLFGLSVSIGGVIERSQVMSLFPQALPSPWLAMMLMVVILVILGMIM
+DPFGAVILVSATIADLAYQSGIAPVHFWMVTLVAFELGYLSPPVALNHLLTRQVVGESEM
+NLSYRESGSFYQRHERVLMPLLVMGSALLIVAFVPLLFYAR*
+
+>12FR_NODE_3#PROKKA_00041
+VSNTYTDLSSARLVELALERNEGKLAANGALVVNTGRRTGRSPMDRFIVEDPATAELIHW
+GPVNRPFDAAKFDALWERVESHLEERDQFVSYVHVGADPEHYLPVKMTTETAWQNLFGRN
+LFIRPDNYNPIDKGEWQILNAAGFVCEPERDGTNSDGCVILNFAERKVLIAGMRYAGEMK
+KAMFSVQNFLLPEQDVLPMHCSANVGEDGDTCLFFGLSGTGKTTLSADEDRYLIGDDEHG
+WGRGTVFNLEGGCYAKCINLSKKNEPIIWDAIRFGAIVENVVIDNDSREPDYDDVSLTEN
+SRCAYPLEHVEKRVLENRGGEPRAVIFLTCDMTGVLPPVSILNKEGAAYHFLSGYTALVG
+STEMGSSAKLRSTFSTCFGAPFFPRPAGVYANLLMKRMEEFGSRVYLVNTGWTGGPYGVG
+KRFSIPTTRAIIRGIQTGALENVQTQHLDDLNLDVPVEVPGVDSNLLNPRNTWQDKEAYH
+HKAQELIAQFVENFKKFDVSDAIVNAGPKLKD*
+
+>12FR_NODE_3#PROKKA_00042
+MTGQDQLQRFLFENSNIRGSIVRLDDTFQQATGQQDYPTVVRNLVGQSLAACALMGDSLK
+FQGSLSLQAQGEGPLRLLVSDSTDQLTLRGLAHWNPEAAEAETLPALIGNGHLVITITPD
+AGQRYQGIVPLEQDTLAGCLEDYFRLSEQLATFMCLFADEKGAAGLLLQQLPGELAGPDT
+DLWPRAIKLAQTLTTEEALQLPSEELIHRLYHQEQVRLFPARATRFGCSCSRERTRLALE
+SLGQDDCMALLDEQEVIEIDCHFCGQRYRYDRADVRAVFGGPRLH*
+
+>12FR_NODE_3#PROKKA_00043
+MTAHSDQQQQEARIRLDKWLWAARFYKTRTLAKEAIEGGKVHYNGQRTKPGKVVELGARI
+RLKQGWAEKEVVIQGLSDRRGGAPQARELYQETDDSQQRREDEHWQRKMMQAAQMPPARR
+PNKKQRRELQRLKSGQG*
+
+>12FR_NODE_3#PROKKA_00044
+VLACFYFFADSPMLNWSQIDTALLDMDGTLLDLHFDSHFWLEHLPRRYAELKHLDPEHAR
+QSLLSKIEQLRGKLDWYCIDFWSDLLDLDVVALKRETRDRIAWRPHSKAFLERLRACGIR
+RVLVTNSHPDGLNLKIETTGIDQHLDRLFSSHSFGQPKEGPDFWEQLAQQEPFDPERTLL
+IDDSLPVLESARRYGIRHLLAILSPDSQQPPRQPSHHPCVHDFDELFQSLDQFAHQKNRI
+DGLSD*
+
+>12FR_NODE_3#PROKKA_00045
+MRPKLSHALAAILAACVMSLAPMTQAETTQSTPSALAMTGDALFARPALLAMTLVGSAVY
+VVSLPFSLLGGNASEAGKVLVVDPAKATFTRCLGCTMNQNRQNEQKNQNQVATADNTDTT
+SN*
+
+>12FR_NODE_3#PROKKA_00046
+VPELPEVETTRRGIEPHLVGHTVTQLQVRESRLRWPVPDKLDQMLPGQKVGQVARRGKYL
+LVHLERGTLLVHLGMSGSLRVVTRAEALRKHDHIDLTTDAGTIIRFNDPRRFGAWLWTED
+WQHHPLLASLGPEPLSPAFSGHYLHRQSRRRKAPIKQFIMDSHMVVGVGNIYANEALFIS
+GIDPRRPAGRISAARMEALVLAIQQVLENAIAVGGTTLRDFVNSEGQPGYFRQSLQVYGR
+EGQPCRRCGKPLRQLRLGQRSTVFCGHCQR*
+
+>12FR_NODE_3#PROKKA_00047
+MENINRITTGNCSIDPIDNTEPQAYQLRVF*
+
+>12FR_NODE_3#PROKKA_00048
+MWLYGLFHHLPAWQLILIALAMTHVTIVSVTVYLHRHSAHNSVDLNPVVAHFFRLWLWLT
+TGMVTKEWTAIHRKHHATCETEEDPHSPVVKGFSEIMWRGAENYRAAISDEICERYGQRT
+PEDWVERNVYSRYRLGGVALMAVIDLLLFGVNGIWIWAVQMMWIPIFAAGVINGIGHFWG
+YRNFECADNARNIVPWGILIGGEELHNNHHTFPNSSKLSRRWWELDIGWGYIRLLQLFGL
+AKPKGYRPIAHQIPGKMDMDVETVQAIANNRFHVMRLYRKRVLEPVLRQQRSVVEKDIKP
+LYRRVRKLVFREESLIKPQERQSLEQVLQNSAVVRLIYEKSHELQAIWQRRPGMRPQDKL
+NALVEWCHQAEESGVRYLEEFAATLRSYSLRPQTA*
+
+>12FR_NODE_3#PROKKA_00049
+MHLWRIVWVLIVLVAVLGGVYFLFPGTIVNADKSFELWRAGLAVHDINVDDQHIHYVDSG
+GQGRVVLMLHGFAADYYSWPRMARYMKAGYRVIAPDLPGFGQSSRIAADNYGISQQAQRM
+HDFLRALNVDKVDIVGNSMGGWIAAEFAARFPAQTRTLTLIDTGGITAPHPSPFMQAVEK
+GENPLVVHNRAQFNHLLTIVFHHQPFIPGPLKGYFAKQAVEHAAFNEKVFKDLTDDYVDL
+EPLLPKLTMPTLVMWGRYDQILDPSCVEVLKAGLPNATIKWFDTGHAPMLEQPKASAEVL
+KAFLQANRGD*
+
+>12FR_NODE_3#PROKKA_00050
+MPPTRRSPPRQQRVTAKKAGGLSRLRIIGGQWRSRQVPFPPVEGLRPTPDRVRETLFNWL
+AGDIPASRCLDLFAGSGALGLEALSREARHLVFVDTASEVIRTLRENLRTLGCQQADVFQ
+QDAEQFLQRPPATPYDVIFLDPPFRQGWLDKVIPLLQQPGWLKPGGWVYVEHEAELNARP
+WPSHWHEHRQKEAGQVVYRLFHVADALKDTAEGVERAS*
+
+>12FR_NODE_3#PROKKA_00051
+MTAEWISVGLLALLVLAFVIDIGLRLRKPPQKPQPPVAERPPAAPEQREAVPEAKAPPPR
+PEAPAAEEKPAKAEPEAEVVEPEAEAPPAPPVAEEAPPVEAPPAETPAAEPEVEEAPVNW
+FARIKQGLGRTRGNFSEGLSNLLKGQKAIDDELMEDIETLLLTADVGVTATTEIIDTLTE
+KLERKQLKDGDALKQALREELHGILAPSTAPLNIDDGHKPYVILMVGVNGVGKTTTIGKL
+ARRFQDQGKRVMLAAGDTFRAAAVEQLQVWGERNNVPVIAQQTGSDSASVIYDAVQSAQA
+RGFDVVIADTAGRLQNKENLMSELEKVVRVMKKLDPEAPHEVMLVLDAGTGQNALSQAQI
+FQQAVGVSGITLTKLDGTAKGGIIFAIARQLKLPIRYIGVGEQVGDLRPFQAEEFVEALF
+DEPA*
+
+>12FR_NODE_3#PROKKA_00052
+MIRFEHVTKRYEGGHVALRDVSFALERGEMAFLTGHSGAGKSTLLKLIMLMERASEGQVV
+IGGQVLDKLPRRRIPYIRRHIGVVFQNHQLLFDRTVYDNVALPLEVMGIAPREVGRRVRA
+ALDKVGLLSKERMNPMELSGGEQQRVGIARAVVNKPPLLLADEPTGNLDPELSASIMHLF
+EAFNQVGVTVLVASHDISLIRHLGHRVITLDGGRLAQGDRMPDEEALYG*
+
+>12FR_NODE_3#PROKKA_00053
+VDESREKSGRRGAGVAENPTRELLDAYASHHRKIARDSLIRLLRNPIGSLMTWLVMGVAL
+ALPLGLMLLLASAQSLGEGWSDSSRINLYLKQNVDETAAMNLQGKLRSRGDVRDVQLVTR
+KQALAQLRKDSGLSAAFDYLNDNPLPNTLIVAPALQDPGAVQSLSQSLKQLPQVAEVQVD
+LAWLKRLRAMIGLVVNAVWALGVLLALAVLLVVGNTIRLAIENRRDEIVVAKLVGGTDAF
+VRRPFLYTGAWYGLGGSIVAIILVALFEAWLDGPVNRLASLYGSHFQLQGAGFGDFLLVI
+MVGVLLGWMGSWLAVKRHLDAIEPR*
+
+>12FR_NODE_3#PROKKA_00054
+MGTSLQVMDKLIPGANVQAYIQGVNAIPMLTVEEERELAARLQQDNDLEAARRLVLSHLR
+FVVHIARSYSGYGLAQADLIQEGNVGLMKAVKRFNPDYGVRLVSFAVHWIKAEIHEFILR
+NWRIVKVATTKAQRKLFFNLRSAKKRLAWLNNDEVTAVAADLGVEPRVVREMEGRLAAQD
+TAFDAPTDDDDDNAWQAPAYYLEDRRYDPAQQLEAADWTEDSNSRLLEAMDSLDERSQDI
+LRERWLSESKSTLHELADKYGVSAERIRQLEKNAMKKIRKMMGEESIA*
+
+>12FR_NODE_3#PROKKA_00055
+MTDLPRIAFLGIGLMGRPMATNLINAGYPVTVWNRSPEKARALAGQAGVAESAAQAVAQA
+DRIITMLENGDAVQQVLVEQGVAEAIQPGAVFLDMSSIAPEMAKSHAGRLKARGVGYIDA
+PVSGGTVGAEQATLSIMAGGSHEDLEAVRPLLETLGRVTHIGPAGSGQLAKLANQAIVGI
+TIGAVSEALLLAAKGGADPEAVREALLGGFAGSRILELHGQRMLARDFEPGAPSRIQLKD
+MRMILDQARAEDLTLPLAQQAFQSYRALIALGEGECDHSALLLQLEHLNQTRMSDPSDGQ
+ER*
+
+>12FR_NODE_3#PROKKA_00056
+MPRLAANLSLLFNEVPFLERFEQAARAGFRAVECQFPYAWAPEAIAAQLQGQGLQQVLFN
+LPAGDWDGGERGIACLPGREADFREGVERALRYAEIMKCRQINCLAGPLPTGAPPEPYWA
+TFEANLRWAAPRLAEQDITLLIEAINSKVDVPGFLLDHSKLALDLIDRLNLPNLKLQYDL
+YHMQIMEGDLLRTLGANLPQIGHIQFADNPGRHEPGTGEINFRRIFEQLDAWGYEGWVAA
+EYVPEVGTFDGLSCLKSWL*
+
+>12FR_NODE_3#PROKKA_00057
+MFGITATEAQSEYEPTEEPQGETKLRVLVIEDDQDVAAYLIKGLKESDYVVDHAADGKTG
+LLMAAGEDYDMMIVDRMLPGMDGLNIIKTVRATGNTTPVLILSALGDVDDRVEGLRGGGD
+DYLTKPFSFTELLARMEVLVRRTRSSNEPETVLKVADLEMDLLARTVKRAGQSIDVQPRE
+FRLLEYLMRHAGQVVTRTMLLEKVWDYHFDPQTNVIDVHISRLRAKIDKGFEKPLLQTVR
+GAGYMLREDT*
+
+>12FR_NODE_3#PROKKA_00058
+VKIHSQLRNSTFQIALLYMVVFATSVFLLLAFIYWRTAGFMTAQTDETIEAEITGLAEQY
+RSRGINGLIAIVRERVARDPNGKSLYLFTTSDYDKLAGNLSAWPQNVQASNGWINFTLND
+SVGWRGEPHLARARVFKVQGGLRLLVGRDVQELTTLKHLIERAIDWGMGITLALSLFGGF
+MISRSTAKRIEVINQTARKIMNGHLSLRIPARGTGDDFDQLADNLNQMLDRIVHLMEGIR
+HVSDSIAHDLRTPLTRLRTQLENTLLTVEGDAARDQVARAVAETDQLLATFNALLRIARL
+EMTGHSADKSPVQLGPLVHDACELYEALAEDKEQEFVLDIPQDVTIEGDRDLIFQVVSNL
+IDNAIKYTPPEGNIRVLVTQEEDDAIFQVEDSGIGVPDSEKDKVFERFYRVAKSRSQPGN
+GLGLSLVSAVVDMHQGRIELADRYTDGRENPGLKVTLRFPRLKPNRRKEIKPTSTTEPEG
+SAS*
+
+>12FR_NODE_3#PROKKA_00059
+MNTQKLINRALSGLDDLGYQLDSMGITSKVNRHNVIAYVMAEQKHWEGEYDSLVARIDQQ
+RFRVEQIVGRVEGLVRGGAEFALKPVSGLRSLVKA*
+
+>12FR_NODE_3#PROKKA_00060
+VQWMWSYWDVLVDLYTEREGASDLVLTRRMDEVEGKPQFTVGLVYVPKPQPNHAFQFVPW
+LTATPPDVLKRAAEFRGRL*
+
+>12FR_NODE_3#PROKKA_00061
+MLSRAIMAPMDLVLDTAEAQRMALFFDHILIWKLSRRTFNKEDNQRYSSELRYLRERGVA
+LLCGLDIPNLISFGRADGTTWNPMEEMKKDCDLLLPFQVGTGVPDQAENEAHADRLIRHL
+SSRLMYNDKPVVAHAEAVNLNTQGNELNALEITINNIPMPPENIPWEDLIQFRNEEETVA
+KLRALRIWLKDRSSAGQSPREIQEELEHLLYEYRKYMEIQHKKFRQGILSTLISSTPEIV
+ASVATLNFGAAIKSVFDIKGRYLGLSEAELSAPGREVSYIAKARDFLTS*
+
+>12FR_NODE_3#PROKKA_00062
+MQTLNIPSLATVTAITLLTTACANNPTPETLQSRGLHPLDTTQLHQLYSKTLQFDWRNAR
+SRSGSGEYQPNGEISIEWSGESFNGKWRILNNHFCATYASIHNGQEQCYMVYQTGARRYV
+AFLNGDYSYSFNVKKVK*
+
+>12FR_NODE_3#PROKKA_00063
+MSHTSSDHSIAFPLRQKSKLRHLAQELLAKADIRIDGDRPWDMRILKEGVLERILGEGSL
+GLGESYMDGEWDAERVDEFVYHLIRAQLDREVRPWNLILHGLRYRLFNMQSLRRAWMIGQ
+RHYDLGNDLYEAMLDPLMTYSCGYWKTATHLAAAQEAKLELICRKLQLKPGMRLLDIGCG
+WGSLMAYAAQHYGVECVGVTVSEEQVKWARHQYKGLPVEFRLQDYRTLDEQFDCIASVGM
+FEHVGHKNYREFMQVAHRCLDDGGLFLLHSIGNNSRDSGSDPWIDKYIFPNGELPSVGQI
+GDAADDLFVIEDLHNFGADYDKTLMAWHANFEAAWPKLAYLGERFRRMWTYYLLSCAGTF
+RARDIQLWQWVLSKRGVQSGYIRPYF*
+
+>12FR_NODE_3#PROKKA_00064
+MNKGTVLRVARPTDQLEKIAQMYMEGLGFERLGEFREHDGFDGVMLGLRSHAYHLEFTQC
+QHEKAGRAPTQDHLLAFYIPDAVEWVRTCEAMVKAGFVCKPSFNPYWDRLGKTFEDVDGY
+RVVIQKEQWLD*
+
+>12FR_NODE_3#PROKKA_00065
+MKDIQLESTIICPACGHQKTEQMPTDACQYFYECESCHTLLKPRAGDCCVFCSFGTNPCP
+PVQQGDDCCASD*
+
+>12FR_NODE_3#PROKKA_00066
+MSSPVRTATFIGAISVVLWGTLALLTKLTGGRIPPFQLMSMTFGIAFLLMAVRWWSRGES
+GLGYIRQPFPAWLLGVGGLFGYHLAYFKAMTLAPAVDVSLIAYLWPLFIVLLSALLPGHS
+LRAQHLVGAVLALAGCWLLVGRNSQGFDWTYADGYLVAFGCSLIWSSYSVLSRLVRSVPT
+DAVGWFCGVTALLALGCHLLWETTVWPVGTLQWLGVIGLGLGPVGIAFFTWDHGVKYGNL
+PLLGTLAYSAPLISVVLLLLAGFGQASGMLFLASALIVAGSFVAGRAKHASPELAEEPVP
+E*
+
+>12FR_NODE_3#PROKKA_00067
+MTMITPSYLGETIEYSSLHACRSTLEDPTRKQPRNTSTAKAYLDEHFQHKLTLETLAGVA
+HLSVRQLNELFRRQIGMTPHHYLTEVRMQQAWQLLEGTDLSVQAVAERVGYSSLAAFSDR
+FHQHFGHPPSHFRRTGKTLRQNR*
+
+>12FR_NODE_3#PROKKA_00068
+MEAITNGMMNLNRQRHQHLVALRIIFAHGENGGEEVVHIGHVAIKTGDTFPGTGRVDLLC
+LTHCLTSTD*
+
+>14FR_NODE_9#PROKKA_00069
+VKAIDGLEELQLTTNGHTVHFDNYYDQARKKEVTKYLVPADVELDKNLNQMEREAGVKEM
+DDLQRGSYKGREMFVRFFCLGTTGSSFSIPCLQITDSAYVVHSEELLYRRGYEEFKRQNA
+ADPNFEFFKYLHATGEVTERMTSKNVELNRVYMDYTRNCVRSVNTQYAGNTVGLKKLSLR
+LAIRKADKEGWLAEHMFIMRCNGPNGRKTYLAGAYPSACGKTSTAMIPGENIVGDDLAYF
+KVIDGEFRAVNVESGIFGIITDVNSKDDPVIWDVLHTPGELIFGNILVKDGKPYWQGMGE
+DIPATGMNYCSTEWTEGMEGPDGKVASCSHKNARYTIRINDLANKDPEWDKPEGMPMGGI
+IYGGRDSDTNAPVREAYSWEHGVCTMGAMLESETTAATIGAEGVRKWNVMSNMDFLSMSV
+GRYIQNNLDFAKDIERPKVFGTNYFLKKDGSYTNGKLDKSVWVKWMELRIHGEADAIDAG
+YGLIPKYEDLAKLFKQVLKEDYAKEDYAFQFRVNIPALIAKLDRMEEIYSTKVTDTPEIM
+KAEMKAQRERLEAIKAAKGEIVSPFDLD*
+
+>14FR_NODE_9#PROKKA_00070
+MTQGLGPGLVSPAPFGAEEKPRGGLGEMGAFYAKGVTYWRSVTTP*
+
+>14FR_NODE_9#PROKKA_00071
+VKPASVLLATPDGEGFYRFSDPVRVVTAGSLEEVLPTVTAVEAAVAQEGVFATGFVSYEA
+GPAFDRALAAYPPGEFPLVWFGLYRNREVVPKTEMQDVPPLAWRPCLDQDEYVAAIRRVR
+EYIEAGDTYQVNYTFRLHAPFAGDPEALFARLASAQACRYAAYVDTGRYVVCSASPEMFY
+TQNADVFRSRPMKGTRPRGMTLAEDRAHREELLESEKDRAENVMIVDMVRNDLGHIAEAG
+TVHVPELFSAEPYPTVWQMTSLVEARSRAGFGQTLKALFPPASITGAPKPRTTEIIRELE
+TTPRHIYTGTIGYLGPEDARFNVAIRTVLIDRQTQQAEYGVGGGIVWDSDPLAEWEECMT
+KTRVLRTVRPEFSLLESLLWTPDEGYALLDRHLARLCDTAEYFGYPVDVVSVRQKLEELA
+GNLEPVPNKTRLLVDRHGEITVEGSPLGPAPDALVWRVCVHPERVDSHDPFLYHKTTHRA
+VYTQAAAAHPDCDDVILQNERGEITESCRANVVVEMPEGRFTPPVSCGLLAGTQRAELLA
+RGEITEKVLTPEDLYAATKVFLINSVHGWVVAELSDSSD*
+
+>14FR_NODE_9#PROKKA_00072
+MTAFPRTDVGGVSVSRLIIGTNWFLGYTHSTSAQSRTNSERVNHRDVVAGIVETFVEFGV
+DSIMCPHTDTVIPEAIEEARQRTGKPLVVISTFALPVTKRTALDGFDLGEVERILDEQVA
+RDVDIAMPHQSVTDIMLDKCSREIRQMAPVCALIRDRNMVPGLSTHAPETVIYSDETGLD
+VESYIQPFNLMGFLMQVEVDWIARIIQNAKKPVMTIKSMAAGQVRPFQALTFSWNVIRPQ
+DMVTVGTSSKHEARELCEMSLQILDRRATTQELQRTRSKASISPA*
+
+>14FR_NODE_9#PROKKA_00073
+MRWQRAMLFVAVLVACGGCSWRGKPRANHVRMYCLVDLEPVAEKLIQGFTESQGVRVDVR
+YIRPDELNKRLQRDEYVGLFLYANTWSGSAEENLLRARGNGGGRPAELGRFTPCLIVPKG
+NPKGIRSAFDLGKPGMVHGRTRQGACLLARISESGYRKPPKGPDTEPSNIRVRDTDYDVA
+RLVAGGSIDGAVVWSFTQSAMADEVEEVESKGLKRYGNVQHMVVGTPMSTPQPGLVKAFI
+EFATGPDGQAILRKTGLDVDPKCR*
+
+>14FR_NODE_9#PROKKA_00074
+MRIATFLLPLLVAIAGAAPKVETGTDGLRVRTARYVATFSTDSGLLASLALVDGTPLLTS
+SRLYADVLPDGRKNFSAKAKAAPKAKPQPDGSLLVEVAGALLDKDGKPHPTYPFTYTASY
+RFDDTAQVRVSVSVIPGFDSDAVFGFLGQVLSTASQREFFVNTADGLISEMAATHSGRTY
+QSESEPLDLKDPYLGVLLKTGQILQFRLVSGAESLLNVFFHDSGAGPTHLFLCPLSGSNP
+RQAKTGKAWQQELVIEAMPLAEWTKSR*
+
+>14FR_NODE_9#PROKKA_00075
+MKPHRLAIFLGTFPMLFSLLLAGEGTMKEAGKSLRFGNGRLILTFDRDTGIWTGLEASGG
+AVCFRRTADSPSLNVQVDGKPVFGADRKMSLREQKVVQLPTASRLELTMGQGDWAVTAAY
+TLWDSGTLQRQATFVYSGPKPEGDHEVRNALFVLPDVGLAGTDAFWFATAEYPPRDHPFR
+HTDSGRRFGFPFSESTFHGFLARDPQAKLSLVSAYYTEDERAKLLVQEGKGTATAFHTHL
+LAETLRPGLRFEVGSQLLRVVPGTRQDALRALQGFYDLPGLRTKIGMPPDTGRQIFYSAH
+PGGTIDSSFRDVGGFANFTKLLPSIRDLGVNTLWLMPFWYGPVYAPYDYYRLDPKRCGTP
+AELKALTDKAHALGMRVLGDLIPHGPREEPGAKPSFAEQHGDLVCRDKDGKMIQWWGCHY
+CDYANPGWQDYMAKHAAYWVRECGLDGYRVDVAAGGAPNWRPYDHNRPSFSGLHGGLALL
+RKARAACLKENPNTIFLAESTGPTMYSAVEHGYHWAFSTLLEDHVLKDAPADFVQAMSGY
+LENQTYAFPADAFPIRFLTNHDKLRARYRYGPNLHRTLLALCAFMKGAPLLYEEEEMGNE
+DFIAKLYRIRQTYDELSVGTVSYRSIPVEPKHVFCIEREYKGKRSVVLINFSNQMSEVKL
+SLPKSDLKNPGIYEAVSGQRVDYAQDLTQSLDPYAYAVLVIRQRDELPPSVPKERGESPA
+APDGRAMDIKITQEDSLTRVSTPLYSAVIDSARGGLLQEVRGADGKLLVNGVELKEGRRK
+LFVGHDSVDFADCSVPLRILARDRQFPDGGKVSLLRGRAELRDGDGHAWMDLTVLYSLRA
+KSLSLNVSLTPQYRLSPSKSDLGMKIHFVPTTHWFAETAEGNLLGHVIRRHPASHGFSGR
+YWHGAGEAFFNGSLYPVVGEFGVLDTNRRIALGSMALRLDGAPLPVRLLEDEPPGSPVVL
+GGPAAATADIPLLRGSQRAVWQQGKAKGMVVTLDFRSVPARFTQYPDSFGVRGWDTGTPK
+LCYRGGWCTFGPEYLFRGYGMRATVVRSHGGELTALTDAAGNGLRVTDARFYTDQGLFGD
+WRDPRGVLRKMSASNVNDPEPDTQLLHLFEGPQDSAPLRFRSFFRHPHAGGRSLLNPRVE
+YEISYTPPTEKGKGLRIDCGVRPHLVKIGTGGFLAYKISLGGCDQWQVDGGEWQPLPAKG
+GRLWENKEAGHLPKTLLLRNSKTGLWTRFSDFVGGPDQVENVFLHAGQGQVHLFVAFYDA
+EPTDVRPVWRRAAFTMQAGGKQ*
+
+>14FR_NODE_9#PROKKA_00076
+MNIYVGNLPYSVNDDELRGVFEEYGSVDSARVIMDRDSGRSKGFGFVEMGNDTEANAAIE
+ALNGQDFSGRPLTVNEARPRADRGPRRGGGGGGFDRRPRY*
+
+>14FR_NODE_9#PROKKA_00077
+MNIYVGNLPYSVSDDDLRTAFEEYGAVDSARVIMDRDSGRSKGFGFVEMGNDNEAQAAIE
+GLNGQDLGGRPLTVNEARPRADRGPRRGGGGGGFDRRPRY*
+
+>14FR_NODE_9#PROKKA_00078
+MNIYVGNLPYSAGDDALRTAFEEYGSVDSARVIMDRDSGRSKGFGFVEMGNDDEAKAAIE
+GLNGQDLDGRALTVNEARPRSDRGPRRGGGGFDRGPRY*
+
+>14FR_NODE_9#PROKKA_00079
+MAQLQTRTTQVIVQNQLGLHARPVTLIVKLAKTFSSRIAFERGGTVSDAKSVMALLLLAA
+GKGTELTITAEGHDAEEAIEALERLFSDKFGEE*
+
+>14FR_NODE_9#PROKKA_00080
+LSDSSRTSSARNEPGETVLAGTGVSPGTVIGKAVVVGASVVSVREHELPVSQLEDEVGRF
+RAALEKSRRELEELRDRARDEKNQDLVDILEMQVMVIEDGMLDQEVSDRIRDTRRNSGFV
+LKNYVDEFCDQLVKAGSAFFAERTNDIQDLAGRILRQLLGSESVDLSELPEPCIIIAHDL
+SPSDTAGMDRDNVLAFVTAMGSRTSHTAIMARALGIPAVVGLGESLAQVGDGVRLVVDGT
+QGRVVVSPENATLVKYHERIEQEKAWRAKLEVNALLPAETRDGFHVSVAANVELPEEVER
+IRRVHRVGIGLFRTEFLFVKGGSISDEEQQYAAYRRVAEDVAPHSVVFRTLDIGGDKFLS
+HLDVPVEINPFLGMRAIRFCLRREDVFRSQLRAILRASAHGGVRILFPMITTMEELHATL
+AILDDVKAELERQGIPHNPDLDVGIMIEVPAAALIADKLAPHVDFFSIGTNDLVQYMMAV
+DRSNPDISYLYQPGHPSVVRLLDRVVRAANEHGRWVGICGEMAAEPLFVPLVLGLGIHEL
+SMSPVAIPIVKDLVRDINMLEAEELVDQAMACGSAEEVTQLCRSFVERIAPELFLD*
+
+>14FR_NODE_9#PROKKA_00081
+MSISIASQPGLTWHPAYCRPRTEKVVDDYCKRHDIPCYLPLLRQRKRYQRRTVETYLPMF
+PGYVFVQLGPDTRTTFLECHRIVHIVEVREAQERTLVAELTELQHLETAQATVDLEVMPD
+IKPGTQVTITDGPLAGITGVVEKRKGKTRVTVNVELVGRSVVAEMDLGELELDGDA*
+
+>14FR_NODE_9#PROKKA_00083
+VYFRQYKVEGLGCYSYLIGCPAAGTACVVDPERHTGQYIQTAEHQGLRITHVFDTHLHAD
+HITGSAELAAATGATICVHPAIGAEYEHEDLLDGQHYRFGAAELEVVETFGHTPNSVSLA
+LTDHGRSEDVFALLTGDLLFVGDVGRPDLAGADLLEEQIHNLYESLYTKLGRFPDWTEVY
+PAHGEGSLCGKGMSAKPMTTLGFERLNNPLLADLEFAEFHRIMTEAFQVRPDNFAAIVAK
+NQRGPQLLREAPAFMELSVLQAERALAAGAQIVDTRAQSAFGAAFLPGSLNIGVSPSSVN
+WLGMLVPADTDIIIVADSKDVACQVADQFRRAGYDRLIGYVPDGVASWALQGKPMDHLPQ
+LTPASLKHVVGRYGNHVILDVRTDAEWATGHIEGAIHLPLPRLVREGIDLGKDRHITTVC
+RSGYRSNVAGSFLKSQGYEHVFSLIGGMTAWQAANR*
+
+>14FR_NODE_9#PROKKA_00084
+MERSSLALPCSGGSCLHAAVRAQMTMQRTAFSLSIALSAVLASALLVGIVPLLRGGDNYE
+LAVKSALLVLVVGYAWLHWRAVTRRGRCLLKAAFCLNALVLVPLGATAALCHVFGGPKIV
+PREAGAIGGAIAILAAAAAAMQVILLTRCRTIELTVPKGD*
+
+>14FR_NODE_9#PROKKA_00085
+MAQPYEGLVGTSGRVQVNRNGRPAFSISTGAFADGWRGASLTPAKVGETTDGVCLGKISL
+PDKLTIASALRATAAGKAMELRYTLTPKADAKLNSLHVSFGLPASFLKGASYTIEGETKE
+VPAVLGATHLRAGDHVPSVRFTWPNGDWLQVDILSKTPVLFQDNRQWGDSFDLRLGPQMV
+PAQTLPANQPVEIAMRVSAKDGMKLDFDRPVTITAGKDWVPLDLELDIEPGSALDFSGLG
+QFDAPSGKHGWLQATPDGKFAFADSLDTPRRFYGVNLCFTAQYLSHDEAERLAERFLRLG
+YNTVRFHHHEYPLIDRKNGCSTDLKPESIDQLDYLFAQFKKRGIYVTTDCYVSRPVYASE
+IWDGAKGNVEMNEFKMLVPVNERAFENWKTYNRNFLTHRNPYTGMRYADDPTLAWLSMIN
+EANFGNYIRSVSDRARPDWERAWGAWLKARYGSAEAITKAWGSTFDGDLSKPTAKLAKSF
+TDDNRQSRDFAVFLADTERTMFLKMKKFLREEIGTKAMLTNMNGWTNTPQSQLARAEFDY
+VDDHFYVDHPQFIEKSWRLPSRCPNTSPVLAGAPGGRGTAFNRLMNKPFTISEYNYSGPG
+RYRGVGGILTGCMAALQDWSVVWRFAYSHRRENVLKPSTAGYFDMATDPLNQAAERASMC
+LFLRGDLDPAPRSAAITLNPETLEKGDSHQGRTPPSWDELVPVIQVGTFLGDRQSKVPAD
+IALPTTDAAPAAADVVMPKPYDSGKGSAILKELRAKGWLDAANKTDLDRKRGQSASDQFL
+MDGEKDMMVLDTPRTAGGYAEAGQTIHTQAADFSILDTGATVWISSLDKQPITSSKRLLL
+THLTDLQNTEVRYAERGRKTLLAWGKLPHLVRVGEAKISLHRSGAKLPKVYVLATSGHRL
+GEVPVTKGKNGTLELAISTKGEAGAQLMYELDFR*
+
+>14FR_NODE_9#PROKKA_00086
+VDHALLDRHFPRYTEYDPQVPVWDLTPQCPGAFHRFFDTSPLSPSGRYLAVTRYQPERLP
+EPGEAAEVVLVDLHTGKSQVIWESRGWDTQLGAQVQWGATDEQLFFNDMDPADWQPFGVC
+YNPLNGTSCRLAGTVYMVSPDGKQAVSPCS*
+
+>15FR_NODE_1#PROKKA_00087
+MFLAGALIVFRIGIHVPVPGVDPTAYAHLFNQNAGGILGIFNVFSGGALEQMSIFALGVM
+PYISASIIIQMLTSVVPSLEALKKEGQAGQRKITRYTRYSTVALALFQSLGAAFALQSQG
+VALTAGPGFIVTATVSLVTGTMFLMWLGEQVTERGLGNGISMIIFAGIVAGLPSAIASTL
+ELVRNGELSSIVAILIFVGVLLITAFVVFVESGQRRITVNYAKRQQGRRMYAAQTSHLPL
+KLNMSGVIPPIFASSIILFPVTLAGWLGQSSGFGWLNTLQLWLSPGQPLYVALFAVLIIF
+FTFFYTALTFNSDETADNLKKSGAFIPGIRPGKQTAGYIDTVLTKLTLWGALYLTAVCLL
+PEFLIAYAHVSFNFGGTSLLIVVVVAMDFMGQLQAHMMTHQYEGLLKRARMRGLQR*
+
+>15FR_NODE_1#PROKKA_00088
+MKVRASVKKICRNCKIIRRRGAVRVICSDPRHKQRQG*
+
+>15FR_NODE_1#PROKKA_00089
+MARIAGINIPPHKHTVIGLTAIYGIGRTRAAEICATAGVDPTRKVKDLSESELEAIRQAL
+TAYKLEGDLRRELNMNLKRLMDLGTFRGIRHRRGLPVRGQRTRTNARTRKGRVRRSAKR*
+
+>15FR_NODE_1#PROKKA_00090
+MAKPAAKARKRIKQQVVDGIVHVHASFNNTIITITDRKGNTLSWATAGGSGFRGSRKSTP
+FAAQVAAERAGAVAQEYGVKNLEVEIKGPGPGRESAVRALNNLGFRVLSISDVTPIPHNG
+CRPPKKRRV*
+
+>15FR_NODE_1#PROKKA_00091
+MARYIGPKCKLARREGTDLFLKSPIKALDQKCKIDRIPGQHGQATRRGRMSDYGLQLREK
+QKLRRMYGVLERQFRRYYKEAARRKGATGALLLQLLESRLDNVIYRMGFASTRAEARQLV
+SHKGVTVNGQLVNIPSFEVKGGDEVALTERARKQNRVEMALEISRQIERPAWVEVDEKAC
+KGTFKAMPEREELLPDINENLVVELYSK*
+
+>15FR_NODE_1#PROKKA_00092
+MEISVSEFLKPRIAGLTELGENRTRIVLEPLERGFGYTLGNSLRRVLLSSMPGAAVVEAE
+IDGVLHEYTAIDGVQEDVVEILLNLKLLAIRMHAREEATLTLNATGAGVVTAGDIQVDHD
+VEIVNKDLVIAHLAKNGKLSVRLKVMRGRGYMPVVKRYADESQGRKIGKLKLDATFTPIR
+RVAYYVEAARVEQRTDLDKLILDIETNGTIGAEEALRRAAGILTDQLSVFADLSSVSSHT
+PTESRSVKPILLKPVEELELTVRSSNALKAERIRFVGDLVQKSEDELLKTPNLGRKSLTE
+IKDVLARHELALGMKLEDWPPAALAERRAS*
+
+>15FR_NODE_1#PROKKA_00093
+MRHRNSGRALSRTSSHRAALMRNMSKSLIEHEQIRTTVPKAKELRRVVEPLITLAKSDSV
+ANRRLAFSRLRDDAIVAKLFTDLGPRYRERPGGYLRILKAGFRPGDNAPVAIVQLVEEQE
+TTSAAT*
+
+>15FR_NODE_1#PROKKA_00094
+MRKVRVAIVGAGTAGLTALAQVRRRTDEFVIVNDGPYGTTCARVGCMPSKALIHIANDFH
+RRRRFAEVGIAEGETLRIDLSKALAWVRAYRDSRTADSIKLTDPLGERNIPGRAELLSAH
+ELHIRRADGGEERIAADAVILAPGSTPVIPKSWDGFSARILTTDTLFEQRDLPRRMAVLG
+LGAIGLEMGQALARLGLQVHGFELRDRLGALTDPQLIAPAIEHFSREFDLHLGAPAELHP
+TGEYWRVETADAQVEVDAVLAAFGRRPRLDGLGLERLGVPLDAKGLPPVDPHTQRVADLP
+IFLAGDANARSPIMHEASDDGYIAAVNALDGPTPLNRRVPLVMAFTDPEMAIVGASFESL
+PAGSFDAAGYDFSRQGRAIAMRHAEGRLRVYAERNSGRLLGAEIFAPEGEHLAHLLALAL
+DRGLNVAELLRMPIYHPVLEEGLRSALRALARRVYDQPPQEFRRLPEGCPGMSSSSP*
+
+>15FR_NODE_1#PROKKA_00095
+MNPYERYLLPWLIDAVCALPAAARERAKIVPRARGEVLEIGIGTGHNLPYYAPRRVAGVT
+GIDPGVLRRRIMRRAHAAGIEVKLLSLSAESIPAEDASFDTLVSTFTLCSIPDVERALAE
+MRRVLKPTGRLLYLEHGTAPDPRVRRWQDRLTPWWKPLAGGCHLNRDIPRLITGAGFDIV
+EQHSEYIRGPRILSYVFRGEAQPIAVAGSK*
+
+>15FR_NODE_1#PROKKA_00096
+MPKFILKDLSDYQQYRDNRELISSFFENLPNKTLQLIAKPLCGSSAAKLIALVAFAVL*
+
+>15FR_NODE_1#PROKKA_00097
+MLVVIYALTTILTAFIGNNAAAVLVFPLAYAAATKLGQPFLPYAIAIAMAASASFTTPIA
+YQTNLMVYGPGGYRFSDFVRFGLPLNLIVGVISVVVIAWLWMP*
+
+>15FR_NODE_1#PROKKA_00098
+METKTLSGNATPLTDEQWAGLARLGDLGNRLGALVDGPLSGPASAALDRIGALDGQYDLT
+ALAEKLVGTLSALDRAGLLDLLRDNAQFIADNLNTLTPMLDQWLAHIAELPADEFKADAK
+FALALLRKARLVTTFIQEKLAGELTTKAVEVTEFMQRNDTDEAVAEALVQLGRIYRSGLL
+ARLGDLADTVAGLEEGTDLDDQIDVLIKSSTAGGLGTFLIFLKSVSIAMQKVGQEPEPKL
+GGYIGMLHLLRDKEVQKGLRMLTVLPIYLEKRLEKSAS*
+
+>15FR_NODE_1#PROKKA_00099
+MNAKPHVLVLGGNFAGLGSAQKIREFAGDAVDITVIDRKNYLLFVPNIPADVFENKDPAV
+GQRLDLPPVLVKDDIYFVQGEVTELDVDNRIVHYTPSERPGAAPQKIAYDYLVVALGNRL
+AFDKIEGFDEFGDSVSDIYLGNKLRKKLWEGGYKGGPIAVGSAMFHQGDGAKGLEPYPGG
+SIPDALAACEGPPVEVMLSAATYLKKTGQGGPEKITVFTPAELIAEDAGEKVVGQLLDIA
+SGMGFNYVNNAKDITRVTAEGVELANGQTIEAELKILFPDWVAHDFMRGLPISDSEGFVI
+TDLLMKNPKYPEVFAAGDAAAVTMPKLGAIGHQECDIVGRQIACAVGRMNEAAANTPLQP
+VVYCIGDMGDNQAFYIRSNSWFGGDTQVLKMGHTPFLLKMQYKNLFFRTQGKMPDWGLDF
+SELMAEKIAS*
+
+>15FR_NODE_1#PROKKA_00100
+VSWEAILTLVVLGAVVLGLAWPRMPPDLPLVGGLAILAVTGCAPIDKVFSGFSNPGLIAI
+AALYIVAAGLRHTGAVTAPARWLFGRSRRLWVAQLRIMLPTAVVSAFINNTPVVAALLPA
+VLDWGKRHRFAASRLAMPLSFAAILGGTCTLIGTSTTIIVNGLLTSTTHGPGMGFFTIGA
+VGLPVAIAGFIYILLFGRRLLPDRQGAMGEFTNPREYTVEMRVAAGSPLAGQTLEAAGLR
+HLPGLYLVEIERGGNLIPAPGPEELLEENDQLVFAGIVESVADLQKMRGLIPTTGQIFKL
+DTPRPDRRLIEAVIAPENPMVGRTVREGRFRSRYGAVVIAVARAGHRVTGKIGAITLIAG
+DTLLIEAPSEFQRRYRHSREFLLLRPLEESVQPHYERAWIAWLILAAVIGLVTARIVPLA
+PAAIFAAVAMVVTRCINLAAARRAIELQVILVIGAAFGIAAALVHTGAAALIAQPLLALA
+EGSPLGMLVVVYALTTILTAFIGNNAAAVLVFPLAYAAATKLGQPFLPYAIAIAMAASAS
+FTTPIAYQTNLMVYGPGGYRFSDFVRFGLPLNLIVGVISVVVIAWLWMP*
+
+>15FR_NODE_1#PROKKA_00101
+MDTIRIRGARTHNLKNINVELPRGSLTVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAY
+ARQFLALMEKPDVDSIEGLSPAIAIEQKASSHNPRSTIGTVTEIHDHLRLLFARAGTPRC
+PHHGLTLDAQTVSQMVDTVLADPSERRVMLLAPVVHGRKGQYQELLEDLKSRGFIRARID
+GTVYELDPLPRLDGHQPHDIEIVVDRFRIRSDMAARLAESFETALALADGSALIADIDKP
+HTSEMVFSARHACPQCGWSIPELEPRLFSFNNPAGACPQCAGLGRESYFDPGRIITQPSL
+SLAGGAIRGWDRRNPYYYRLIESLARHYEFDTEAPWSELSERTHRVLLYGSGEEEIDFTY
+VSARGQKQQRRHTFEGVLNILERRYHETGSQAVRDELVRYQSSRACTACNGTRLGEIARN
+VFIADTTLPDISNLAIDAVWRFFNDLDLPGRRGEIAKRIQHELHSRLGFLVDVGLGYLTL
+ARSTETLSGGEAQRIRLASQIGSGLTGVMYVLDEPSIGLHQRDNRRLIDTLTRLRDLDNS
+VIVVEHDEDAIRSADYLIDMGPGAGAHGGEVVATGTPEEVMNNPNSLTADYLSGRRTIPV
+PQARRHPQPGQAIIIRDAHGNNLKHIEVSIPLGLFTCVTGVSGSGKSTLVLDTLQAAGER
+LLNRARTEPAPHASIEGLDALDKVIAIDQSPIGRTPRSNPATYTGVFTAIRELFAQTPEA
+RARGYKPGRFSFNVRGGRCEACQGDGLVKVEMHFLPDIYVPCDLCHGSRYNRETLQIHYK
+GRTIEEVLNMTTEQAREFFANIPSIHHRLDTLVTVGLGYVKLGQSATTLSGGEAQRIKLA
+RELSRRDTGRVLYILDEPTTGLHFHDIRQLLAVLLRLRSHGNTVIVIEHNLDVIKTADWI
+IDLGPEGGHGGGQIIGEGSPEDIARLEHSHTGHYLMPLLKPHKLQKETTT*
+
+>15FR_NODE_1#PROKKA_00102
+MAGSGKLRKDAGIIGLLYFSLGGIIGSGWLFGPFDAAKAAGPWSIASWIIGAAVVMLLAL
+VFAELATMMPKSGALIHISHIGHGELIGRIWSWILFLSSVVTPPIEVMAVLTYLNNKIPY
+FVDPSTHVLSTIGFFAAIVLLGVVVVVNFFAIRFVLWINNIATWWKMFIPAISIIVLMSY
+SFHPGNFHLDLGSVNAAGMLTAVSTAGIVFSFLGFRLAINLGGETKNPGKYIPIAVIGSV
+LIATLIYVGLEVTTITSVRPSDFANGWPSLAFKGDAGPFAALAVTIGAVWWSWVLYADAI
+VSPFGTGLIYTTNTSRLGYAMAEVGSAPKKMQKLSRQGVPWISLLVTYVIACIFFFPFPS
+WHQLVGYVSDITVLSYGIGPVVLLIMRKRRPEEPRPFRLKGAKVIAPMAFIASNWVIFWT
+GCTTVTFLFGLLGSLFAVYAIWYYIIARKPSKEFGWKYAWWVFPYFIGMWLLSYIGPSTL
+GPAHVSLFNVQPLDILPLGWDMIAVAVFSLAVLYTATSSALPREEADRYFDELKKLNLPE
+EYSEGTESP*
+
+>15FR_NODE_1#PROKKA_00103
+VQATDWLHQIAGPALVLNFADGTVIDINAAGRRLVGIEGQGLIGQDFCGFFVSSDADCCW
+PTLQRSINLQGGFRYEGLHLRTPGGAMRRVNVSAELLQSEQERAVLMLLQPGTASSPQAT
+DHEKELAQYATVGLYRLDAEGRLTHANHALARLLGYETVGQLLDSAAVQRSQWYVCDGVS
+EERVSDVNDAAIYRCKVQLRRAHGAAFRAVEAIREIRDVRGQLMSRIGTLREISDQSSSE
+QALAISEDKYRSLVEHSQDGVFVIRDGVYVFVSQVYSSMLDYAPEEMVGESFLRFFAPED
+RQKIVDVWHERQAGHWEQGAYEAHLLKKDGTRVLVSVRAGPIRFAGAMASTGTVRDITAY
+RDTQQQLSMAEQRYRDIFEHAVIGIYQTAPDGRLLAANPAMAQILGYDSVEELQEQVDDV
+GELFFDRIERDTLIEKLEAEGRMYGAELRLRHRKGTQLWVQDSARVVYDANGKLVCYEGM
+VADITARKIVEQALHRSEQLFRTLVEHTHVGVIMVREGVVTYANRALAHMLDYAESDLLE
+QPLASLFAPESRDCVERLEQELKTAVGSNIYESSMLAADGTRRVRANLSVASVIFEDNPV
+MIITAHDLTREKRAEARLRRLATHDPLTNLPNRVVLRERLAQVLKKTRETGNVDWAVLFL
+DLDAFKLVNDSLGHAAGDELLRQVAVRLRRAVRHDDLVCHHGGDEFVVLAFNITHEIDAV
+ELAEHIETAMAEPFRISDHEIYNQITIGIALGRQEYELPEEVLRDADSAVAAGKRLGKVC
+HVVFSSSMHVAAMERLELETTLRAGLTRGEFDCYYQPIFNVKNNRIESLEALLRWHHPEQ
+GVLRPHSFLQVAEESGAIVPLGWIGLRRALAACSQWQSLGLEREVSVAVNLSDAQFRLPQ
+LPEQLAHELEQAQLPFHLLHLEVTERVFLETPGLARRTLGRLHALGVKLYLDDFGTGYSA
+LSYLRELPFDALKDRS*
+
+>15FR_NODE_1#PROKKA_00104
+MLSDLLPPPVIEVFATGLAIHGLTVVIPLKTIAPHISEYARLFGLFHPFGNDQELQVIGQ
+*
+
+>15FR_NODE_1#PROKKA_00105
+MPTRRELANAIRALAMDAVQKANSGHPGMPMGMADIAEVLYNDFLRHNPANPHWPGRDRF
+LLSNGHGCMLQYAALHLSGYDLSMDEIRNFRQLHSKTPGHPEYGHTPGVEVTTGPLGQGV
+ANGVGLALAEALLAAQFNRPGHKVIDHHTYVFCGDGCLMEGISHEAASIAGTLGLGKLVM
+VYDDNGISIDGEVKGWFHDDTQKRFEAYGWHTIGPIDGHDAEALKKAFAEAQIETKRPSL
+ILARTIIGFGAPDKQGTAEAHGSALGDAEVAKARKELGWKFPPFEIPESIYAGWDARARG
+EQAETEWHERFAAYAKAHPQLAKELKRRLAGELPADWATTVEQHIAHVARNGKAQATRKA
+SGATLAALAPTLPEIVGGSADLTPSNDTCWPEAKAVKPGTPEGNYLHWGVREFAMTAILN
+GMAVHGGFVPYGGTFLTFSDYARNAVRLAALAHYPTILVYTHDSIGLGEDGPTHQPVEHV
+ASLRAMPNLTLWRPADDVETAVAWRDAIERRDGPTMLVLTRQSVPHYERKAQQIEAIHRG
+GYILHEPQNAPRALIIATGSEVDLAMQAARVLTEENLPVRVVSMPCQELFLAQDVDWQEH
+VLPAQVTARVAVEAGVSMPWYRFVGIHGRVVAMERFGESAPAKQLFEEFSFTAERVAAAV
+REAVAAAAG*
+
+>15FR_NODE_1#PROKKA_00106
+MIKVGINGYGRIGRNVMRALYESGRRDQLQVVAINDLGDAQTNAHLTRYDSVHGRFPGDV
+QVEQGHLVLNGDVIQVLAERDPSKLPWGKLGVDLVLECTGLFTSREKASLHLQGGAKKVL
+LSAPAKDDVDATIVYGVNHKTLEPEKHVIVSNASCTTNCLAPIAQVMHELAGIEGGIMNT
+VHAFTNDQNLLDVYHKDLRRARAATASMIPTSTGAAKAIGLVLPELDGKLDGFAIRVPTQ
+NVSFVDLTLNLTREVKVEDINRAMREAADGRLKGVLAYNEVPLVSIDFNHNSHSSTYDAG
+FTKVKGRLVKVCSWYDNEWGFSNRMLDTAAVMFGRG*
+
+>15FR_NODE_1#PROKKA_00107
+MGVKSLKDCELQNRRVLMRVDFNVPVNDGAIADDTRIRAALPSIHEALKAGARLMLMSHF
+GRPEEGKPESRFSLHPVARRLGELLGFDVPLVTDYLARDPEPGSGRAVLLENVRFNVGEK
+RNEETLARRYANLCDVFVMDAFGSAHRAQASTYGVARFAPQAVAGELLCAELKALGRALK
+APDRPLIAIVGGSKVSDKIGVLDALIERCDGLVVGGGIANTFLAAAGHPVGRSLYEPGFV
+DEAKRLMIAARERGVNFPLPVDAVVAEALAEDAEADVKPVHAVGAGDMVLDIGPETAVLY
+RPLLANAATIVWNGPVGVFEIDQFAEGTRAVAEAVASSGAFSIIGGGDTIAALAKFGVTD
+RVSYISTGGGAFLEFLEGKTLPAVDILEARASD*
+
+>15FR_NODE_1#PROKKA_00108
+VTETMARFRRTKIVATLGPAVDEGDVLARMIAAGVDVVRLNLSHGTHAEHRKRVKAVRKA
+AAEQGRDVGVLIDLQGPKIRIECFRDGPIELKEDDAFTLDCGLGSNAGDSKRVGVAYKNL
+PRDVQAGDMLVLADGEIVLEVREVIGEQVHCRVETGGALSDHKGLNRRGGGLSAEALTQK
+DQVDIQLAAELEADFLAISFPRVAADVERARALLRAAGGTAAIVAKIERAEAVENLDEII
+DASEVVMIARGDLAVEIGDAPLPGVQKRIVRHARARNTVVITATQMMESMVTSPTPTRAE
+VLDVANAVLDGTDAVMLSEETAVGRHPVKVVEAMARVCLGAEAEPREDRDRRIGGDRFEL
+VDEAISMAAMSVSQHTDVTALVALTESGRTPLYMSRVRSGIPIYALTRHECTRRLLTLYR
+GVYPIAFEDEHESDEVLPDVAAALLERGLVTPHALIIVTRGKLRHVSGGTNSLHLVQVAD
+VLPEQVL*
+
+>15FR_NODE_1#PROKKA_00109
+MNGHWAREKRRMRVINRLLGLSAVVMVLVLVSPTASASIASDAVAYPPVSLSNVPPAKAE
+EIRKGEYLTKLSDCMACHTDHGNGKAGKPFSGGLAIKTPFGNIYSPNITPDKKTGIGNWT
+FKQFDDAVRYGEGPNGYLFAAMPYNYYSMMNKDQVHAIWEYLKHVPAVNRRNKPLGMPPP
+FRWRWLQFGWRFMFVKPTQGEFKYDPKHSKAWNRGRFIVEGPEHCGACHTPHNMLGGSEK
+RFFLGGSDITGFWAPNISGLATKPHPIATIMRVFREGKGLGGGDLKGPMIDAIANSMRYM
+TPADMRAVAVYIQSVQSEVPPGPRPVAMDEVNLARGEKTYQTDCAACHATGIGGAPRVGV
+AKDWDALGKSPLFILFENVWHGVSIMPPKGGCKACTRDDVTSAIVYMLKRSTSRSSKPAV
+QATTSKSGIPRDTVSLAVGDKIYHAHCAACHASGAAGAPRHGDIKEWASRLKLGLDKLHH
+NALDGIGMMPPKGGCTSCSKDQILSAVDYLVDGSGGKALVEKSLSGKQGG*
+
+>15FR_NODE_1#PROKKA_00110
+MSGDSILRIFWWLVLGAWMSGIGVMLGRELGLTVLLRYLGRNESERRELLAPHIERPSEG
+HQVWLLLGGGALMAAWWPLFTATLFGGLWLVLLFMVLAVLVGPVGHGYRKRLSEHTRGPW
+DLLWAGISLAALLVFGLAIGATVSGVPLHFDAHMDAMWGGFFSRFTPYSLLVPGLMAITF
+GLWLAAARAAHECTGAVAARARALLLPVGGVTLLIFAGGAAWATQLPGYAVGGLPKVGAS
+PLDGTTFAVGGAYLERFLSHLPLVIVPVLTALAIVGALFFSWRGRLQRVGPLVVIAVVGM
+VATLGAMTYPVILPSFAEPAQSLTLWNAAAERPVLVAFLVWLGILVPVVLGYELWLRRRN
+AQTVVAGSTAR*
+
+>15FR_NODE_1#PROKKA_00111
+MNATAPLQEQEPEPGNRRFPGLLMGGARQVARWSWQHRRYGRWPLRILLVLLLVLIILVG
+AGYGLLRGSLPQTEGTVRLPGLGGRVVVTRDAQGVPTIRAHNALDAWRVLGYLEAQDRFT
+QMDFMRRVAAGDLAALVGPAALPLDRIHARFDLRARAERIYLDAPSVERARLEAYTLGVN
+EGLDNLSVRPWAYLLLGERPRAWEPADSVLVIYAMGWMLQNPLGPRMRARAALRSLYPPA
+VTAFLGAPDTHWAAPMAGQPPALPPVPGTQLINLSASGKSRATAPVPSTAMYADTVAKLI
+LPQPFPGSNSFAVSGDLTGTGHALLANDPHLSLRVPATWYRARLIYPAPGATASQPVELT
+GVFLPGVPALVIGTNGHIAWGLTNSGGDWTALVRVKATAAGSRGGPLVYATPSGTATLAI
+QHVLLKVRGQTARPMSIRRTIWGPVIGTTADGALLVSHWALAQPGGVNLRFMQLDSQTTV
+KQALMVAGSAGIPVQNFLVADDQGHIGWTLAGRIPVRKAGCDYAVPQSWADGSCGWTGWL
+APGSYPSIVDPAQGYLATANNRVDARTAAVLALGDENFADGARAHQIVSDLKALAKRGKI
+TANDLHDVQLDDRAQFLQRWHDLLLNVLSPSALEFHPHRQALREAVVNWGARAAVDSVGY
+RMVRAFRNEVAASMFMPILKRLHTRDPGAGLPFSNQLEGPLWRLLQVRPHNWLNPAYPTW
+NALLVHAADAVIHRFWNPVSGLADATWGARNTVRINQPLAVALGPLGHWLDMPPTQLPGD
+SNMPRVQTPDFGASMRMVVSPQPSAPGLFELPGGESGHPLSPWYSDEFKAWAEGLLTPLA
+PGPARKTLRFIPWSRRVSDRPTVSTGSVVPAQSGQ*
+
+>15FR_NODE_1#PROKKA_00112
+MKKIVIANLKGGSGKTTVSTTLAAFWASEGYKTCLLDLDPQRAATSWLRRRPESLPSIHT
+LSLPNQTSGVTLSYALRIPRDTERLVVDTPAGLSGIALADTVRGAAAVLIPVLPGTMDSD
+AAARTVADLLLIAKLGRHSGRMAVIANRVRRGTLGAERLQKFISALDIPLIATLHDLQAY
+SHAILSGLGLHELPRRRIGGERMAWVPLLEWLERRELEITAQTALGPRSLLTQSAGQTPS
+DSME*
+
+>15FR_NODE_1#PROKKA_00113
+VLAGIAEWYGEDEAVPFRVISGTSAGAMNAAYLSANMENFAHGTQRLAQVWSQLEAQQVY
+RPEYRKVFGALLHWAWSLLSGGLGDSNPRSLLDNSPLRALLAENIDFDAIARNIERGLLR
+GVSVTVAGYSTERSLSYFQAETGVQSWWRQRREGRPVQMTLDHVMASLGLPIIFPAVKVA
+GEWCGDGSTREFAPLSPAIHLGAKRVLVIDTQYPAPQHVLGQDQAYPSLSKIMGYLFDSV
+FSDSLYADLERTKRINRTLDYIKRQSGHEPPELGLSHIDTLVIAPSRRPLEIASRYESHL
+PKSMRWILRSLGGDVSSGDQLLSYMLFQSGYCSEMVALGRHDAHARREEIGQFLGLSKIK
+VR*
+
+>15FR_NODE_1#PROKKA_00114
+MNLILLGGLSGAGKTGALDMLEDLGYQIVDNLPLSLIEPAIDAMLGDDARHHSRLAIGIA
+PHNTPEEFEALARQIEIWRTRPHGCTVIYLFCEPGTLVKRYRATRRRHPLTGPDTDLAAA
+IEIETTLLEPLAQLADACIDTTHTNIHQLREIIRARVNEGGDHPMALQIESFGYRRGLAQ
+DADLVFDMRCLPNPYWEPTLRELTGLDQPIAEYLETHGTVTRMLSNLVNFLNAWLPSYAA
+SNRSYLTIAIGCTGGRHRSVYMAEQLAAQLAHGGWAVTVRHRDLDTPTRDVKPILADD*
+
+>15FR_NODE_1#PROKKA_00115
+MQNTITGRHLDVTPALKDYVNTKLSRLGRHHEPPTSTQIILSVENLDHKAEGILQVRGGT
+VYAEANETDMYAAIDILADRLDRQLVRHKERHASHHATPTARLNMEN*
+
+>15FR_NODE_1#PROKKA_00116
+LLALPRPDLEQILETALEENVMLERLEPETGEGDPEVATVMEQTEPAGEWDELSWSSSAG
+TGERPDMQTFEDIRPPDLRQHLIEQLVLERFSDRDFLIALALVDSLDDNGYLREDLDTVS
+QELDALDPSPELIEIEAILHRVQRLDPIGIGARDTAECLSLQLEALPPDTAGLVVARELI
+DGHCARLTQADMATLASLTCSDEDSVRRALSLIQSLNPRPGNDYSAQTAEYLIPELRTYR
+TPDGWQVELYPGNHPRISINATYVAWLSANRLNEASQSLTRQLEEARWLIRSLAQRENTL
+LRVARVLVRRQTAFLDQGVMHLAPLTLREVAKELDMHESTISRAVQGKAMSTPRGVITLR
+HLFSNALSNDNDEAISARAVHERLRHLLNHEDPAAPLSDAALAAALARDNMPIARRTVAK
+YREALGFASTRARKRPAHSVAISKG*
+
+>15FR_NODE_1#PROKKA_00117
+MSQLRAENLHKRYRTREVVRGLNLNVNSGEIIGLLGPNGAGKTTTFYMILGLVPTDSGNI
+YLDQRDITGLPIHARARAGLGYLPQEASIFRNLSVRDNLIAVLELGGHGTRAEQQRRADE
+LLDELGVTHLAKDKGISLSGGERRRVEIARALANEPAFMLLDEPFAGVDPVSVADIKRII
+DHLAKRGIGVLITEHNVRETLDICNRAYVMNRGTMLAEGSPKEIADNQTVREIYLGDKFT
+L*
+
+>15FR_NODE_1#PROKKA_00118
+MHPKLFACCTALLACCAFPALGTPAPGSANASSSVSGVMTINADHSSMANTTGQGTEVTY
+SGHVIVTRGALRLYGHSAVIHGRSNTIGKVVVTGTPARFELREPGKPHVLGEADSITYNG
+KTDILQLDGQVHFSRPGEHFSAAHITYRIATRQLEASGNGNGRVHAVLSPAARTSP*
+
+>15FR_NODE_1#PROKKA_00119
+VRLSRGWAVASAWAALLGAAALTSWLFLRSHDHSPATDLASHAVERPDYLLHQAIVTRFA
+KDGSRRYIIKARRIAHMPRNNIALLTRVDLDYFPVHGKPWHLQSDNGRLFANGTRLNLIG
+HVRAHELDTPIPVHFLTTEVTVLLPEARLASRYRVILRQGHRETRGTGLAANLQTGTLSL
+LKDVTSQYAP*
+
+>15FR_NODE_1#PROKKA_00120
+MSTPLAAIRLLALDVDGVLTDGRLWYSETAGEIKAFNAHDGAGIKRLMREGIAVALISAR
+QSPIVTHRARELGIIQVHQGVKDKGHCLTETAQAVGVRLAFCAFMGDDEADLPAFAIAGL
+RIAPANAVARVRDEADWCTQATGGQGAVREVCERLLAARQANAGGKS*
+
+>15FR_NODE_1#PROKKA_00121
+VNRPASATGLIESGREVIQIEAAAVSALESRLNETFAAACGLLLACRGRVVVTGMGKSGH
+IGRKLAATMASTGTPAFYVHPAEASHGDLGMITSEDVMIALSNSGQTPEVVTIVPLIKRL
+GVALIALTGEPDSMLARASDCHLDISVSREACPLNLAPTASTSATLAMGDALALAVSAAR
+GFTPEDFARSHPGGRLGRRLLVRVADIMHTDDAMPIINESTRLGDALVTMSAKGLGMAMI
+TDVQGRLAGVFTDGDLRRHLDQGVNLDTPMQHLITRECTVATPDMLAAEALRLMETRHIN
+SLPVVTDDKPVGAFNMHDLLQAGVV*
+
+>15FR_NODE_1#PROKKA_00122
+MDRTDLQQLLEQAFPNAEIEVQSEDGVHFAARLIDAGFSGQGRLARHQTVYAALGARVGG
+EIHALSLQTLTPEEAGARA*
+
+>15FR_NODE_1#PROKKA_00123
+LNRLLIRGGGRLDGEIRISGAKNATLPILAASLLAETPITIGNVPHLHDVTTTVTLLRRM
+GVDVTVGEHMALEVDSNTIKDMVAPYELVRTMRASILVLGPLLARFGCAEVSLPGGCAIG
+SRPVELHLKGLSAMGADIDVRNGYIYAKANRLRGARIFMDMVSVTGTENLMMAAVLADGE
+TVIENAAREPEVVDLANCLNKMGAEIEGAGTETLHIQGVAKLEGCYYEVMPDRIETGTYL
+VAGALTGGRVRVKRTRPDMMESVLEKLREAGAEITSKDDWIELDMKGRRPQAVTLRTAPY
+PAFPTDMQAQFTALNAVAEGSGAVTETVFENRFMHVQELVRMGARIQLEGNTAMIQGVER
+LTGAPVLATDLRASASLVLAGLVAEGETVVDRIYHIDRGYECIEEKLAQLGAHIRRVTS*
+
+>15FR_NODE_1#PROKKA_00124
+MILYSRPDDPAAHSIRLVLAEKAIGVKIVEVEPDSPPEDLLHLNPYGTLPTLVSREVVLY
+DPRIIAEFIDERYPHPSLLPSDPVLRARARLFVSEIGGSWYELCDEVANGAGRGRTRARR
+ELTEAVVSSDELFTGTAYLLGGDYGLADCVAAPVLWRLPHLGVRLPREAKAIRGYMQRVF
+KRPTFVYALVASERAMIES*
+
+>15FR_NODE_1#PROKKA_00125
+MTEKPRPSRKPYLVRALHEWMGDASLTPQIIVDATVDHVDVPVEHVHDGKIVLNLSLEAV
+RDLELGNDAITCTARFGGVARSLWVPMKAVLGIYARETGEGVAFACS*
+
+>15FR_NODE_1#PROKKA_00126
+MEAITNGMMNLNRQRHQHLVALRIIFAHGENGGEEVVHIGHVAIKTGDTFPGTGRVDLLC
+LTHCLTSTD*
+
+>16FR_NODE_10#PROKKA_00127
+MTTPDINFTDLLQFLFMGIQRGSIYAMVAMGVV*
+
+>16FR_NODE_10#PROKKA_00128
+VKRTLLSTAIAVLFLLSAVSVYAAQKKPYKVGCVFAITGGASWLGGPERNTAEMLAKQIN
+AAGGINGHKLELFIEDTQGDNTRAVNAVKKLIKKNHVCAIIGPSRTGTSMAVIPIVQQAK
+IPMISCAAAESIIAPVSKRKWIFKTTQNDSDAVRRIYENMDKKGIHKIGIITGTTGFGAA
+GREQLKALAPHYKIKIVADETYDPTDTDMTAQLIRIRNSGAQAVVNWSIVPAQSIVPQNM
+RQLKMKIQLYQSHGFGNIKYVEAAGAAANGLIFPGGRLLAADTVSASNPQKAILMKYQKE
+YEAAFKEPPSTFGGHAFDAISILAKALKKVGDNPAKLRNVIEHTNFVGITGVFHYTKTNH
+CGLNQNAFEMLTVKNGKFVVLHQ*
+
+>16FR_NODE_10#PROKKA_00129
+MKISQLSIFLENRSGRLARIATVLGNAGINIRAMSLADTSDFGILRLIVSDTEQAEKTLK
+DQGFTVLISAVVAVAIPDSPGALGNVLSIMEHAGLNVEYMYAFVEKDMGQAIVIFRFDDV
+DRAISTLIENDIAVLESKRVLRL*
+
+>16FR_NODE_10#PROKKA_00130
+MIRVGVAGATGYAGAELVRILAGHREVRITALTSRQYAGVPFAKVFPALAGVVSNECEAF
+DVERVCGQTDVIFTALPHKLPMAIVPGLIKNGKKVIDLSADFRFSDVRLYESAYQPHSSS
+DLLSRAVYGLSEVYTDDIRKADLIGNPGCYPTSTLLPLVPLLKNRLVDSGGIIVDSKSGV
+SGAGRSPSLTVHFSEVNESFKAYKVAAHRHEPEIESILTKSAGTPVDITFVPHLVPMTRG
+MATTIYAGLAGNVTKHDIAACLCDYYAGRQFIRIDRDGHPPDTRNVRGTNYCDIAFVVDE
+NNRRLILMSVIDNLVKGAAGQAVQNMNLMMGFEETAGLSAPPFPV*
+
+>16FR_NODE_10#PROKKA_00131
+MSRSFKSAGRMADPSDVAADICPVPAFIPDLMAVNGLADAGFSRLIFFPGMLFGSTEKWW
+GDGGVRPSAHEGLDLCFFETSDGLRYRLDETVSVPAAFDGKIVRIMDDLLGRTVVVQSRC
+APSDAPFYTFYAHIRPDNGLRQGDTLAAGTVFAAIARIVSPKIRLPAHLHITLARANDLP
+PVDTLSWPVMNRLDRSVFLNPLDLLMCDYAIEDDTRFTPGSDAVKPVRRIRQDRKGA*
+
+>16FR_NODE_10#PROKKA_00132
+MGLFSIFGGKPPEELERRGDFHYEAGAFGDAKMAFEKAIDRIERRFPEKKHLLPRIMEKY
+HLARNALAKMHVENGDHMITVRDYEEAGALYRLAMELTSDEAFAAEIHGKIAKLKDLIAD
+EDEPEMEWVGDAREEAYVDDWGGAEEDAGGAEDDDAYADDDMTADAEGMADETDADAQLY
+DSPENLFHVLVSALPEAVQDAYLGYGEAFAAGYIALNHGEFRKAVKELSRALEENASAKT
+LIPVELATAYMHLNDPDHARQILEDFLKENPGEIRGYQLLCEILWEAGNTADARNLLSGA
+PNDIQTTRPMQMLQGETLFQVGLYDEAEKVFTRCLEIHGKDEIVNRGLAKTYEAKGQIEK
+ARDLYADILNRCIMCGSAADPIIKRRYADLCIKSGDKSLKLLELYFGLAKEDPDNRADYF
+FRIADLYEAQGKDIEARKYRKLSTQAGGGKRPQ*
+
+>16FR_NODE_10#PROKKA_00133
+MNPIEAISHTGRSVRSRLKGFPRKKVLVLEGGGMRGIFTVGVLQAFSERGYAPWKTIIGA
+SAGALSGVVYAAGQIHMARDAFFTELISGRFIRMSNIFRPEKHILNLDWLVDHIIGGDEP
+LNIRRLRTTACPVLITVTRFSRDFPPDTLYLSTKTDSVPQALKATAAIPFFYRGFVHYRN
+DLLLDGGVLDSVPFKKALSMGFPERDILVVLTRPKGYRKERDSFWIKTLYESYYKDSQYR
+YLVNSLEHHFGNYNRMLDDLETNYDFDIIYPPDNFKVNRLTRSEDKIVDGFEQGVAAAKA
+YLKPKS*
+
+>16FR_NODE_10#PROKKA_00134
+MRKKIHLFLVIGCIVFCFSPAVFAKTGGPKVLHYPREDAVVRAVKLVSPAVVNISTQYEV
+RTRVNPFANFGANDFFNNFFDQGIERKEKLTSLGSGVIIDGRRGFILTNAHVVVRGAKIT
+VVLKDGRKFHADIVGIDPESDLAVLKIKTKSPLPSIAMGNSSDLMIGETVIAIGNPFGFS
+NTVTVGVVSAVDRSFRIKNRIYRDLIQTDASINPGNSGGPLLNIDGQLIGINTAIYKNAE
+GIGFAIPINRAKKIISDLIKYGEVVPGWIGLSVQNLNSRLAAYLNLPQHSGVVVRSVDPS
+SPAGAAGIREGDILLAIDGHKIESIDDYKTAMRGYRKGQHAVVKIDRNGRHLTLSVRIEV
+FPESLAPELVQRLLGVKVVGIGQKVRFNQTINADKGVIISEIDPQSSLAGIGVRPGDVIR
+KVDAEATNTVQSFYKAMIKDRWKQSIVILLQRGDQGYYITLKLS*
+
+>16FR_NODE_10#PROKKA_00135
+MFQFLLFVGSITAFIIGGLIVLIGIGAITGCAGGILAMCSGAIIAVLGAWSAITFFLPSP
+DPSVPARETINLIRRNGRWM*
+
+>16FR_NODE_10#PROKKA_00136
+MHLVKKYANRKLYDTTDKQYITMEKLAELIKSGSEVMIIDNETGDDLTAQVVSQLLAREK
+NEDDTALPSSVLMQMLRKGRGTLFGYGKKYISLWQSAVLMSRDENEKLINTLVKDKELSE
+TEGRTLKKEITAYTNGLKTWIRENIDQRVNEALNMMNLASKEQVKELIDQVESLSLKVQS
+LEREIRRKN*
+
+>16FR_NODE_10#PROKKA_00137
+MRKQVEIMSSIDNFWLYMDHPTNLMIITGFLQFDKPINFERLKQTIKNRLLCYDRFKKRV
+IRPMTGVGNATWELDPRFDLRSHLHRVALPAPGDKETLQELISDLTATPLDPTKPLWQLH
+YIENCENGGSVLFARIHHCIGDGISLIRLLLSLTDTEPNAVWSDCLNEPKIEKETSFNLF
+PPLESAMKKVTRARRRAQKVTRFVSREIEKSFSNPYHIVKRTRTVTKFALDVATVMSKIL
+LLPADRKTVFKGELGVRKSVAWSDPLPLDDIKVIGKYFNATINDILVALVTGALRRYLQQ
+CNNLVGDLDIRVAMPINIRPIDGDIELGNQFSLILVALPVHIDDPVLRIREVQRRINDLK
+EAPDAAVAYAVLNALGVSSAKLAKTAATMFANKTTGVFSNVPGPRQQLYFCGEKINNIMF
+WVPRIGGLGIGISIISYNNEVSLGIATDSGLVQDPKAILDHFANEFRMLLGMYKAGQMEK
+EPLVINDRSVEPPVFAFNTEKIASVQAIRCKAITRSGTQCHNRAATNSMYCTLHLSKYET
+IASREENDMPAEADNTLPAEDQAAG*
+
+>16FR_NODE_10#PROKKA_00138
+MNAPAPTPNNPRIVVCCGSGGVGKTTISAAIGLCGALMGKKTVVLTIDPARRLADALGIS
+ALNMEAQRVPLEASVPASGELYAMMVDAKRTFDRLIGRYSSAGLRDRILENRYYQHVSNN
+MAGSHEYMAMERLYEIYHEKRFDLIVLDTPPSRRALDFLEAPQRVINLLGHPYFLKLFKP
+YIKAGQLSGRLFNLLAMPVLRAVGQVVGGQTISDIFSFFQLFNDMLFDGFSKRASAVESL
+LSDPMTTFFAVTTPQEYPIQEATYLFRQLQQRNMPFGGFIVNRVHSDTADSPFDSEAADR
+KRVLMEKIADKPIFQRLEIADRMDRKLARSDAAAIDRISSISPGLAVFPILFADETVNDI
+SGLRVISTQLMKHPEFKI*
+
+>16FR_NODE_10#PROKKA_00139
+MAKADESDRTQLEALFSIGAGVRSLDELLTRRLIFLMGKGGVGKTTLSVALALTAEMMGK
+RVLLTEIGDSQGIGRYFDAQPDVRPRQVSSAIWAARVDPKDELTAYLHYHMKSGFIANRI
+TQSRLFDYLLAATPGLKEIMTLARIWRWEKAKNKAGTPLYDTIIVDAPATGHGLSLLRLP
+KMLVEMIRVGPIASQVNGVQQMLLNPERTALTLVTLPEELPVNETREMIDIAVDEVGIPV
+QAVFINGVHPVFVTPDEFSRIQELDRDCPDADPDCPDLRFALDVARRQIVRNAAQQVQMN
+EVHAAAPGHVIHVPYYYTNDLGPEEIRTIAASLHRQISEAPRGGGR*
+
+>16FR_NODE_10#PROKKA_00140
+MYQIKRYANGRFYDTVEKNYVTREQISKLLGAGKKISIIDTRTEKDITDDIVSRIKAKKQ
+NPSKSKKAGKSNKAVDDSTGMLVQLFRKGGDALFDYGKRYASMWQNMVTMSRDEVDKLVN
+MLVKDNKLTELEGSKLKKEIDRYRTNIQGWITRNIDNRVNEVLNRMNLANRDQILELTGK
+IEELNKRINRLGKEKKGPAKTKKTS*
+
+>16FR_NODE_10#PROKKA_00141
+MAKTATKKGETAQTKITGKIQKAAESVTDKVKGYNEKYVAKNIEKGKATLKEYNEKYLVK
+TVEKGKDTLKEYNDKYITKAVEKGRSYVDGPYKKLSGTMDQWLEKGRSFEKDAWKKMDGY
+VENGKKFMYKLPLVETVEKKVTSSLNSVPSVVNLPGKGDIEKLTLAMEALNSNIEALRKQ
+SAQ*
+
+>16FR_NODE_10#PROKKA_00142
+MGKTIRRALVLSGGGARGAFEVGVMRYLNEVNWQPDLICGTSIGAINGAAFGSGMSVDEL
+AHLWKTYHRKQMYKITFPAFFRTLLSGRKFSPLSDNRPTRSLLEKTIDIDALRNSTTEII
+ISVLNMRTSQVRYFTHKAIGIEHLMAAGGIPMMFPWQYIDGDPYWDAGVMVNTPIMPAFE
+RGATEIIVVLLSPLGAIPQRLPSTHREVSELVFEQFLIGSYTACLPNAGWRTNPEADVYD
+TPLPDSPQLQLSMKGVRMATVYPTRMLGFRSLLDFSPRQAKTLLRDGYVNARMQLKSFFK
+*
+
+>16FR_NODE_10#PROKKA_00143
+MPTATIRQQLIELLSENKYDARDLSQRLGVRETVVYDSIPHITRSVTSMGKKLKIVPSRC
+TSCGYTFKDRKRAAKPSRCPTCKSERIAKPKFYIV*
+
+>16FR_NODE_10#PROKKA_00144
+VKTVSISGQTGASKIVIGERLENLSNYLPDRRIVVITDTNVAGHYGKMFPDVEVITIGCG
+ESIKTLDTAKMIYERLVSMAADRSVFIVGIGGGIVCDITGFIASTYMRGVRFGYVATTLL
+AQVDASVGGKNGVNFMGYKNMVGVFNQPEFVICDPYVLGTLPPRELACGFAEIVKHAAIS
+DKDYFADLEESHEKACARDPETLERIIRKSVVIKAGVVNADEKERGERRKLNFGHTLGHA
+IEKTLGVPHGEAVSAGMVMAAELSANRGHLPRPDIRRLKDLLTHLDLPTALPIDPERIID
+AMARDKKRQGEKIHFVLLSAIGAAFVDSISLAELEAVVTG*
+
+>16FR_NODE_10#PROKKA_00145
+MLIVMRQDASREQIDAVIRAIEARGYTARSIPGGDRVSIGILNNRTAIDAAWFQDMPGVK
+ETIPVTRPYKLVSREIQPHDTIIRVGGVEIGNGHLVIIGGPCAVESEAQVMATAERVKKA
+GADIFRGGAFKPRTSPYAFQGLGEEGLKILARAREQFGMPIVTEVMDLEYFDMVEAYADI
+VQIGTRNMQNFSLLRRAGESKKPILLKRGMSATIDEWLMAAEYVLSQGNPNIILCERGVR
+TFVRHSRNTLDLSAIPVVQRESHLPIIVDPSHATGFRDQVIPLSRAAAAARAHGLMIEVH
+NAPDTAQCDGSQSLYPDQFETLCRQVRSIFRILGETDETR*
+
+>16FR_NODE_10#PROKKA_00146
+MILIDILRRNWYDLLPLNEIGNICAVKFGNKAADP*
+
+>16FR_NODE_10#PROKKA_00147
+MTNATNDQPFRPARFTEQRLITAILDGTCPPGSVLPAERRLAEQFGVTRPTIRETLQRLA
+AEGWITIRHGKPTRVNDFWETGGCS*
+
+>16FR_NODE_10#PROKKA_00148
+MEAITNGMMNLNRQRHQHLVALRIIFAHGENGGEEVVHIGHVAIKTGDTFPGTGRVDLLC
+LTHCLTSTD*
+
+>2FR_NODE_5#PROKKA_00149
+MIGNYGGLEHGLLFNLFRRRAFRRQYEEALEEARGLVATFSRNLADRLFDPVGALPMIER
+RRIEICRALIAHPKLLLLDEPSAGMTHDETHQLMDDILSVRDRLDGLAIIIIEHEMGVIE
+RVSDHCVVLNYGRKIAEGSYQDVASDRLVQEAYLGSA*
+
+>2FR_NODE_5#PROKKA_00150
+MTAVSSAVSDSAAVPQTADVAVEIEGLFTGYDKADVLLDVSRTVPKGQITCLLGSNGAGK
+TTLIRSILGLTPPRQGTIRLFGEDTTGLPTHKVVARGVACIPEGRRMFSKLTVEENLRLG
+AYQEPSEAKIRTSLEDVYQTFPRLAERRNQLSGTLSGGEQAMVSIGRGLMGAPRLLMIDE
+PSLGLSPLYVQENFRIIENIRTRGITVFLVEQNVHQTLAISDYGYVVSGGRLVAQGAAAS
+LQNDPEVHAAYFG*
+
+>2FR_NODE_5#PROKKA_00151
+MPAKIPDPVELTRRLVAFETINPPGQEQACAAFLADLLAGAGFDCVLHPLGDDRASLVAR
+RGRPTEQRLPLAFTGHIDTVPLGAVPWKHDPFAGEIVDGRLYGRGSSDMKSGVAAFVVAA
+IAEAERIGDGAGVELVITAGEETGCDGARALADGGHLGRAGALVVAEPTANRICVGHKGA
+LWLKAITHGVTAHGSMPEHGDNAVYKAARAIGRLADFDFNVARHPVLGRPTLNVGTVSGG
+LNVNSVPDRATVGIDIRTIPGMDHAPLRDGLGGVIGEGADLETLCDLPGIWTEPELPWVQ
+RAAAAVAAVTEQPFAPESVAYFTDASVITPAYGDIQTLVLGPGEPSMAHQTDEYCEVERI
+VEATDIYRRLIADWMKPES*
+
+>2FR_NODE_5#PROKKA_00152
+LEGLGAEGEKAVATLELIVERASGDVLKVELKPGTNVPAIHPGDKVQIVTPAGETLNAVV
+VGQDVQITPVDASGTVGETIVFKNLALYLHDGQSEVAVVNADTGQTTEITDVASLADLGT
+VPLQMASGEGTGPVSPGTSSPFQNSDAIDHGGETAGNAAGTLGDILNRGAAGTDGGRAQL
+AGTGETGAGTGTGSSTTDHVETPISESTEGGGSGTGTGTGTTTSGHAVDGYIVGATVFAD
+ANANGVLDSGEASTTTSYNGTFELSGSSGQLVMTGGVDQATGESFKGTLTAPAGSTVVTP
+LTTLIQSLVEAGQSAADAQAAVKSALGLTGNSIDLTTANPVEDVENGVSGADDVLAAAIK
+IQNTVVQAASVLQGAGGSTVAMSTATNAVFAQLATTLQNNPGSNPITDATAVQNLITGAA
+NSSSLGLSSTAKTQVGNAASDAASVIDAGNSHINGLSSTGSSLLTDLASAARVAQNGAAE
+ALHDALNAVQGTSNSANLSTATSSYTGANLTSEIGNASSGLGTVGTASSVGTSGDDTIQG
+TSGNDTLNGGAGNDTISGGTGNDILIGGAGNDTLKGEAGNDTLDGGAGDDSLYGGAGTDK
+ALFDGNFSGYQIATDSGSSGVITVTGSGTDTIDTTEVLKFKDLTVRMVGDSGGTANGYTS
+LSSALSAASVGERILILDSATDPSTLTLSKKVSVQKIGEDPLISIASDGALVVDGSQLSA
+VTTLDLSSLPGTTTVRFTSLGSIASISTASTETLNLSASQLDGLTVSGSGKIQTSGIVAT
+SADLSNLSSDLSVASGQSLELTAAQASGKTIAGAGNVTVNALGSSAVDLSGITASGTLTA
+NVPSSATLNTNTDLGTFGVSVASGQTLTLSATLADGTTIGGDGNVTVTGLAAATDLSSVS
+ASGTVTATVTSTVDISSNTHLGSVDAYQVTGALTLTAAQVGDSTISGSGNVTVSGLAATT
+DLSGIASSLSLTASVTSSIDISANTNLTTVDTYQVSSGQTLTLSAAQAAGHAISGGTVTI
+SGNITANTDLTDISSTLSFDDGDSGAISVASGTKLTVTPSQAAALQTAGQTITGDGTVLI
+DGNVTADTNLTNISAAVDFNGNSVSVDSGHTLTLTATQASDTTISGAGAVALSGSDTNAD
+LSSITADITVASGQTLSLSTAQLATLDSNAIPIGGDGTVSLTGNATSALNSDLSTYLGSS
+LNLAVPSGESLSLTAIQANGLTMEVAGTANITGPAGTTAADFSNISFTGSGAATFTVGAD
+LVISEANADFGSVSINIPAGRTLTIDAADASGVTISGDGTLAVTGTLDSSVNMSNWGTGA
+IDLTNVSASNFSLTQLDLNGSADYHLTYAQVQALSDGIDGNNSDNTLIIDVSTAGGVTYT
+NNAATIDLDISLLGGADRVKFDFGGTTDSGNTLTIRGPLGFGDGSDTLESRHGTISLTDP
+GLTLSGGPEALVANSGFSLTATLFDLLYGSSGVTLQGEGTYIVSIDAGFASGASPTLDLT
+VLDNFVPAGGVLPTLQIVATGYSVVGGDDGTGDGIATLSDGTHTITIKLPDDPDNAGTFN
+PGNTPVIIEIDNGTSQFFLGGLDDQRAYYESETTVYTGSQFADLATAIATDASSLGINAG
+DIQTIKLGDSVILDSDSAVDLSAFGGVIDYNGQTIQVTSGDSLTLTAAAADGGTISGAGS
+VTITDLGTTAVDFSGLTAASVTLAISSGTVDLSAISGLDLGNVGITVTTPGAVTLTAAQA
+DGLSISGNGDVTLTGLGASEVDLSGLTATNATAEISADLTLSSLTNLGSLDLTLDDGVTL
+TLSRAQLDGRDISLASGSATLAFGGNASGLDLSQIASGIAFEVVAGRTLTLSTAQINDGH
+TITGAGSLVVVLSGTEVDLASTAIQVTGTRTAVVSTSATLDGNTDLGDFSVSILSGQTLT
+LSTAQAAEHAISGAGNVTVTGIGSTAVDLSTITVTGTKTVSLSADATLDPDTNLGNFAID
+TAGHSLQLTVAQANGLSITGSGTAVVTGLGSDTVDLSGITATASTTVSDTVALAAGTNLG
+SVAVTVDGTGSLTLSASQADGHTISGTGAVTVTGLTAGIDLSSLASSLDVTATVPGTVDI
+TGNTAQLATVDTYEVAGALTLSASQASGHTIEGSGSIVVSGLDGSAAYDLSGITASASTT
+VSGTVTLDSGSNLGTVAVSVTGSLTLAAAQATGHTLSGDGSVTVTGLAATTNLSGLASTL
+SLTAAVTGTVDISSNTLLGTVDSYTVSQSTDALSLTAAQASGHAISGSGTVAISGLGAAV
+VDLSGIAATVDATATLSGTEVILTAGTDLGTVALSVGSGQTLTLGAAQASGHAISGGGDV
+VVNGLSASTDLSTVTVTGTVTATVSADLDISASSQLGSVDTFQVVAGKTLTLTATQANGQ
+AVEGGGNVTVTGLAAATDLSGITATGTLTATVTADTDITANTHLGAVDSFQVASSTTLTL
+TADQADGQAVTGTGNVTITGLGTTAVDLSAIAATGTLSAAISGDITLAGDTNLGDVTLTV
+GAGNTLTLTAAQADGNTITGTGAVVITGDVAGYDLTHIAGTLDLTLPVTGDVLTLTDGET
+VHLTVAEANAYDSITGDGTIQLSGNATANFDHLTSILGDGVSLAVADGDTLYLTATQASG
+VTIGGIGTVDASGTVTDGDFSGISADLNLTDATLDGTTTLPTVGAGHTLSMTSDQINAAS
+IALADSTATLHVAVSFDALSSSNDALPEIDISEIRVDGSNSPEAVWNSVDVASGSIVDKF
+KLFWISADKQYYDSTPLGQDVDANRAFVELGNLYAAYLAGADGELGTADDGTPILDVVQT
+KSGGVADYDARQQSLHDNLLGNLSDGAIAGRFGTDDPRSDLAKLFGDRPYLAGSVDGNGL
+YTNDDSVAAVVGWDLYHGLDYTASLSGGYAVLDGDNSVTGTSGSDYIYAGGGDDTVSGGD
+GADVLYGGSGDDTLNGGAGDDTLYGGSGDDTLTGGAGADTLSGGDGTDTASYAASTEGVT
+VDLETGVGTGGDAEGDTLSGIENVTGSAEADALSGDANANVLDGGAGDDTLTGGAGDDTL
+SGGDGTDTAVYTAALTTDNITFDTDHWVVATDGAEGTDQLSGIEVIDHGGSGNILLVGGD
+GFASIQDAIDVASDGDTIMVAPGTYAESLTIDKSLTLIGDPATGDAGAGTSAPQILGSTD
+WTLATVSIEAENVTFSGFDVTNDTGPYGIHIKAGDADVSDNYVHDINGALSGDGIRAIFI
+NPVDNVTVSNNIVEDFGNADNPSAASYTKTAAGIYYWARGGTLPGGTADIAELHNVTIEN
+NVIHNDGLPTFTGTSVLGIWVGSSQGGSVLDTVSIAGNQISDLHTDNADRLTGGILVNHG
+SNPDGVDPLASLDTPGVTTGLEISGNTIDDVSGASVFAVGLRGQTPDASVIDNVISNLAL
+ASGSSDGLLASISFQYNTTTHSVSLSGNDLGGYDLLQVGHDTSDDTLTPATADDTLTAID
+GYDNILVGQSGDDTLTGGDGNDTLLGGNGTDTLTGGGGTDTLDGGDGTDTAIFTGTRADY
+TIAVDTDGHLTVTDTGGTDGTDSVSNVETLEFTDTSVSVLTVTETGANGTYSSIQAAIDA
+AADGDIIYVADGTYTQTGTLNVDKAVTLIGQSEAGVVIDASAVHGYGILLTADGATLSDF
+TLNGPQGGDETVWSSYRVDYGIKVSPNGTASSLSDITLQNLTVSGSHNTEIDFNGIHDST
+LSNITVDGGTGVAGNGISLTDSSNITVNDVTAANNPWGGVAIYTDGTHYAGGSDGVTFTG
+DYTYDAGSTGASPIYIQATGNTYPVTNLTLPDGYDFAVTNSEYRADGNEFTFFFTSESDA
+TAFGNSLGAGSFVSTPDADTLTGTANADYLYGGGGDDHLSGAAGDDRLVGGSGNDTLDGG
+DGMDTAAVEGNRADFTFTDDGSGHLVMSDTQGTNGTDTVSGVETLSFTDGNVLVVGAGSE
+YATIQSAIDAAASGDTIVIAGGTYAESLSLDKALTLQAVSGADVVIDPASGNGLTVSGDL
+AGGDVTVSGLTFTDGTMGIQVAANADVGTLTLDGVTVEDNLQYGLRTDSGSMAAVIVTDS
+TFGDNGTQNVNGSAQMKLYNFDGDATFTRVDLVGAPAGTDQNSRPDYGIELTGLSNTGLA
+EGGTSPDLGTVVFTDVTVSGEFHKIGVAVYNYGQIDGLDIQSLDLSGTETNWGPVFNIDG
+VEDSTVDARNYNITYPAGDAIVAELQGEVPDQTATDTTIYGTDANERLMGKAGDNVLHGG
+GGNDELYGADKPGNPAEDDSGNDKLYGEAGDDLLAGGAGADILDGGDGIDTASYARAGAT
+EGVAVDLANGTASGGDAQGDVLSNIENLVGSSYDDTLTGDGNDNVLTGGAGADALDGGDG
+SDTVSYAGSSAAVNVDLATNTVSGGDAEGDILSNFENVTGSSHDDTLSGTSGDNVLVGGE
+GNDTVVYTTTVAASDVSFDTDHWVVTTASAGTDQLSGIETIEHGGGSNILLVGGGGYATI
+QAAIEAAGAGDTILVAPGTYAPFATSFGGPANITVQAMGDPGDVIIDATGGAPSNGRILD
+LRADGMTLDGFTIEGPGHAGVGISINGQGITVENNVISNVLTGIQTGTQYDTGNVTITGN
+TVDADYGISLQNTANTVTDNTVHATTEGLGVLDVAATLSGNSFTVDAGGEGLALYGGATS
+STFTTSGNTVTVGEGANLQHATDLAGTDGTLNIGAGTYEQVISIAKDGLTVNGSDATLVV
+DGSSSDVNGIARVDAVTIYGDNVTLQGLTIVDSLVDQSYVTYGWPETTRGIVVKNGAENF
+TLTGNTIESTRNGILINGIDNTGSVTDNVIDNTKSGISVQYTDASGIIIAGNQEGTYGNE
+WGLNLHLNGYWDGTTYTSNNADNYPILGTAPTADWQASLLGLSTGNDGWAVMDQAYALYN
+RTLVTVDPDGSPSSFSNQGSQRSPISTIQNGVDLVVAGGTVHAHAGDYSGESVTVHVDNL
+ILDGDAGATGITVQLADGLSNLTLAGEADYTATGNAADNTLIGGAGDDVLTGGGGADTLT
+GGDGSDTASYAASAAAVDVDLGSGTASGGDAAGDTLTSIENVIGSAYDDMLTGDAGDNVL
+QGGAGADSLIGGAGSDTASYADSSAAVDIDLAAGTIAGGDAVGDTYSGIENLTGSAYADS
+LTGDSGDNVLTGGAGNDTLTGGAGNDTIDGGAGTDTAVLSGNRATYTLGVNADGNITLSG
+EGTDVVKNVETLQFADDSASILVVDPGTSGAYATIQAAVTAASAGDIILITGGTYTENVT
+LDKQVTLLGAQAGVDADGRTGVTESVIEGNITVSGAADNATIDGLTIHNGASVGGDLAGV
+YLASGATGTEITNTIFTRDGTVDGDSSRGILTTYNGGNTDVTIAHNSFSGWATGTYVNPG
+SQDIQITDNQFDGNYVGLSVDGPNGAVVTGNSFTGNQFEGLGIGPGTGISGITLSNNSFA
+DNASQVGVYTDAIDVNALSGNTFDGAVVISGSDTVYASIQDAVDASSDGDTILVYPGEYS
+ELANYNPTTGENSGTGNPLGLLINKSVTIQGVTADGTYITDAGDVAATVTSGAQSNWGTN
+FFVTADDVSINGLDLVATGSTGQPYVNKSIEVVGDGFTLNHSVLGAADGLPMYTAVYVND
+WSVDSGFTASAIASYAVLNSQLYGDMVVTNGPGTGYTADQLDMRIVGNSFLTIDGGIPND
+GILVTGNDDNIAWRNASAALPTEISGNDFGDASGVLWVRGDGTQDFPTTAEVNGILADNS
+VPAYAYAVDGNGDLAAGTYGSSSIPSLAIRATAADFAPSELSGAGAESLMVQQAGETTPH
+SYSLIVGADGVADSLTGTSGDEALIGGSGDDSLSGGGGNDILVGGDGNDTLTVGDGSAVV
+YGGDGTDTTAYSTTVSADDISFDTDHWVVNTSSGTDQLTGVEAIDTGGSNKILLVGGDSG
+YATIMEAVDAASAGDTILVAPGTYEPFSMGYWSPSDLTIQGMPGAVIDATSISTPARIVD
+LTAEGTTFSGFTIVGPGDVDDAGISVGISISAQGVTVSDNTISDITTGIQNHTPADQTGA
+SSILDNTISGANVGISLQNVNNTVSGNTVTTVEAHTLGVGEVALGVLGGDNTITHNTFTV
+SNSGKAIGLPDLPAVANLTTSENVVTVGEGADLQNAADLAGTNGTLHVGAGTYAQELTIT
+TDGLTVTGDDGATIQVADPGVYSPSSDAFAARTIAFTIAATGVSVSGFEINGPLSAYTYT
+TTDFATLGYTYGFFINDGVQNTTLHDITIQDIRTGMSFEGDNTATVYDNVIDNTRGAFLV
+RSDGVDLHDNSFGSTGNEWDLTMLAGTPSDYFGDPLTDPGTYGDNMMALSAANNDMTIAD
+RMYGEGGVLARAASDPDLADQYAAVANRSHVEVLAGADNDTSAGLGETRGNGFGTERLPV
+GTLQDGVNAVVQGGSVHVQGGDYSGESVTVHSDNITINGEASAIGIDVHLGIGLSAITLE
+GSADFTATGNDLDNTITAGAGDDILSGGDGADILFGGDGNNTLTGGDGADKFMISAHTDG
+SKDTITDFGQGDSLDFHDVLSDPTDVVFTDDGSGNTQITTNAAPTIVLAVVEHVEPASLT
+VDDHGNVTLAQTS*
+
+>2FR_NODE_5#PROKKA_00153
+VKSFSDAGVAANRRNGHRNATPSGRLGHSLSWGSLLLSGLVVFGGPFMADAQAQQLREAV
+EMAVQSHPMVASTEAEYRAAERSVDQVEAGFYPSLDLTADSGYQHARRVNESSIKENQWR
+NKQRLAMTQMLYDGEGTANRAESAKASAQSAHFDVLSAATKIAQRAIRAYLDVARDRKLV
+QYAVDNIDLHRRILADVEEAARSGGGSETRVTQVKTRLYNAQSQRRRAEGNLRNSISDFQ
+EAIGETPETLEDYPMPTVAIPASVDEARDEALKNNPSFQAAVETERARTLTANAERSGYF
+PQVDVEVAHEQRDGVDGVSGFETDSTALLTLSWNLYGGGADQAKVRRALEQSSAAMYRIH
+EVERKIRRELEVALTDYEVARDQVALLRERAATAKEVTAAYREQFRLGQRTLIELLDSGN
+ELFLARSDLTTAEYRQISAAYDFLAVRGTLLKDMGVKVATGKAPKAP*
+
+>2FR_NODE_5#PROKKA_00154
+MTADNASNIKVVHDPQTDEAPARPLGVDTPAGEAPGNDDRPAGPLEDALPGAEDDDSLLS
+CLLFLVAYHGQPKSPSVLLSALPKPDGPIPVDLFKRAAARAGLSVQVVRRGLGRIHAWTL
+PAVLLLRNRGAVVLTGKSDTGHFLVTAGDAGHGTTELSPEELERAYTGFAILVKPEVDLG
+GERTGADLAKPRSWFWGTLAKNGWTYAQVGMASVVINIFAVANPLFTMNVYDRVLPNNAV
+ESGIALAIGAATALLFDFILRNLRGWFIDFVGRRADVVLACRIFDQVLDLKASHRPQSSG
+AFASMLREFETVRDFFTSATLAAFIDLPFSLFFLAVILMLSPEIGMVLGSAMALVLFWGM
+FVQFPIAKSVKKLMVHGEHKHGVLVESLFGYETIKMVGAEGRMRAKWETVVGQSAAVGQR
+MRLFNNLGVNFVQFVQQGTIIAMVVTGIFLVKDGTVTSGGLVASVILCGRALGPMAQVSQ
+LMMRFHQTWTSLKSLDAVMRGPVERPPEANFLHRPRLRGQIEFQEVTFRYPGTDHDVLRD
+ISFVIEPGERVGIVGRVGSGKSTIAKLLAGLYAPTSGTVLLDDTDLRHIEPSDARANVGF
+VPQDVFLFKGSIKENIAISVPRATDDEITEVSQALGLHDFITQHPLGYDLEVGERGGGLS
+GGQRQAVALARTLLKTPTILVLDEPTNSMDTGTEKKVVDTLARTTGGRTIILVTHRTSVL
+SLVDRLIVMDAGRIVADGPKATILGGLAKGQVKTGK*
+
+>2FR_NODE_5#PROKKA_00155
+MASPDIEYMSELRAAVSRRPTILANIILIAVLVFFILAILWASWAKIDQVSTGEGRVIPS
+GHVQVVQNLEGGILSELYVAEGDHVKQGQVLMQLDDTQFSSDFMENRLKFLGLKAAVTRL
+QAELEGTALKFPAEVEKQLPAVAQAERSLFEARRSEEDASLAKLQAQYQQKLHEVDETKA
+KIEHLRTVIKLAKEEMAILEPLVKKGINAPIELIRLKREESQDAGDLAVARQQLLKLAAA
+IDETKEAITEAKAQFRSRALKELNEAQVNMAALGQVVTSRDDRLRRTVIRAPVTGVVKQI
+FLTTIGGVVRPGMDLMEIVPAEENLLVEAKIRPSDIAFMHPGLEATVRFTAYDYTIYGSL
+KATLDQISADTIFDEAKKERFYMIRLRTKTNSLLDKTGKPLPIIPGMTVSVDVKTGRRTV
+LQYLMKPFHKLSIRAFHER*
+
+>2FR_NODE_5#PROKKA_00156
+MITIDQTLTPKDLTEDLARFWTLSGQKIRQLASRWNAGDGAPVFTVEGRYTSRGWTEWTE
+GFVYGSALLQFDATGEDWFLDYGRRGTREHMGGHVTHTGVHDHGFNCVSTYGNLRRLMDE
+GKLPENADERAFLDMALASSGAVQAARWTNLGHGKGYIHSFNGAHSLFVDTMRSLRSLAV
+AHMLGRDLKGEHDQSISLIERLAAHARTTAETAVFFGKGRDAYDEWGRTCHEAIFNVKDG
+HFRCPNSQQGYSPFTTWTRGQAWITLGYAEQLEFFRALEAAGRPEADDCSDLMGIMRDGA
+RATADHYIANTPTDGVCYWDTGAPGLAAMPDHKDRPADPFNEHEPVDSSASAIMAQGLLR
+LAAVLAEEGDDSAERYRQAGLTVARALLKAPYLSEADGHEGLLLHTIYHRPNGWDHIPAG
+RKVPCGESCQWGDYHVRELALMIGREAAGQEPYRFFNGLV*
+
+>2FR_NODE_5#PROKKA_00157
+VASLDLDVRQASLTRYLENRAAFAARRGVSLPMPSHRRGNDPTAPDDVAEMIRAQAAGHD
+VLLVDTPGRVDAVSMAAHVVADTIVTPVGESHLDLDLIGNVDRNQGRAIRPGPYAEFVWA
+VRQERARAGRTPTDWVVCHNRRRAPQTRVGREVERTLADLSKRFAFRLVPGFSERTIFQE
+LFPDGLTLLDLRESETGVGLTLSHVAARNEIRHLVDALDFR*
+
+>3FR_NODE_4#PROKKA_00158
+VIAWVVLLALWLFVTRSRPGKAMLAASMSRTGLALVGYDIGKVYLQVWGLYGLLAGIAGV
+LLASFTGASASIAISLTVNAFIIVVLGGLGNVAGSLGAAYIIGLLGTLTAYLISPSVREI
+PGLLVLILILYVRPQGLFGRH*
+
+>3FR_NODE_4#PROKKA_00159
+MASRIHWDWRAGLVLLALIVLAFLPFGVSGYILGVMTVAFYLAVYAMSWDLLFGYAGEVN
+FGPTFLVGLGAYGAGLSNSVFNISVWPSVAIGTLAAVIGGLVLAGPALRLRGPYFGLVTL
+VAVILLEKVIGLLSSYTGGEIGLTVMDVLTISQSGNYYYAFGFMVISAVILRIIARSSIG
+LILEASGQDPVATEALGFNVTKFKFMAFTLSAFFSGLAGALTVFYLGSASPGTVVSVFVT
+IQIIIATLVGGRRSIIGPILGAVFLIAAGEILRPLGQLSNAVVALIALLVVLFAPNGFIG
+LFSRTGGAR*
+
+>3FR_NODE_4#PROKKA_00160
+MSVLKAQGLYKRFGGLQAVNNVSFSVDRGEVLGLIGPNGSGKSTTLSLLMGVTRPDRGSV
+QLDGQEMAGWRTHRIAKQGLSMVFQHSRPLHRQTVLENIKLALLPDTLWQLFPPHTLDRR
+AREIAERVGLHNVIDTLPGNLPFADLRRLEIAKALAQDPSVLLLDEPFAGLSPRETREFA
+ELVHLFREEGRAVILVDHNVKEVAGLVDRIVAMHAGQVIAEGTPDEVTRDPKVREVYFGQ
+SLENASGIHADGDRRSEGNGSEALLEIDLRSVRYGLAEALRDIQIQINQGECVSVVGING
+AGKTTLFKSILDFQGYEGDVRWQGTSLTGQGPGQVASQGIALCPESRELFGFMTVRENLE
+LGGHKLDRQAHESQMDRVFDLFPVLRQRQAQAAYTLSGGEQQQLTIGRALMQQPKLLILD
+EPTLGLAPLVIENISEALHKLQQDSGMTLLLGEQNLTFALRHSQRIYLLETGNLRWHGPA
+ERFIEEVGEDVL*
+
+>3FR_NODE_4#PROKKA_00161
+MFCNGNQGYDFSINSHPGHAHQMQRRSHATNSQSGPVP*
+
+>3FR_NODE_4#PROKKA_00162
+MQRTARAALCREWNGPIQVETIRVDPPRRNEITIKLRACGVCHSDLSAATGVIPFPPPLV
+LGHEGAGTVIAVGEGVTDFQEGDHVVSSFIYMCGKCRQCSRGRPVLCEQAHKALHHLPDG
+TVRTHDGDGNPLNVFGACGVMAEYATLHVNNAVKIDPDVPLERAALVGCAVMTGAGSVFN
+TAQLEPGSTAAVFGVGGVGLNAIQGCAIAGARVIVAVDTNEEKLAMARQFGATHTVNARE
+HDDAGKAVKKMTGGVDYAFECVGSGVTVAQAYGSLGRGGTAVVVGVADVKDKTTFRTLSL
+PADERTLKGSWLGSARPQFDFPRLLGLYQGGRLKLDELVTHTYTIDEAPQAFEDLKAGRN
+ARGVILFD*
+
+>3FR_NODE_4#PROKKA_00163
+MTIKSYDSVYFDGRWQPVDGERLSVYESGTGEVMASIPGAAPAVMQQAIDAAHNAFDSWS
+RRPLKERLKYIEALHGQLVARAEEIATTISREVGMPLKLSRNIQAGLPIAITDSYLKLLP
+DFPFEEKVGSSLVQYTPVGVVGCITPWNYPLHQVILKVVPALAAGCTVVLKPSEVSPLSA
+FMLAEMFDAIDLPPGVFNLVSGLGHVVGDSLTGSNKVRMLSFTGSPGTGRRIFHAAAEDF
+KRLALEMGGKSASVILPDADLATAVKGSVNNCYLNSGQTCIAWTRMLVPADKHDEACELA
+VAAAKKLTLGDPLDENTRLGPLASKEQLERVRNYIRVGIEEGAKLMTGGPDAPAGLDKGY
+FVEPTIFANVDPQSRIAQEEIFGPVLCIIPYRDEEEAIAIANGTPYGLSGGVWSADQDHA
+IAVASRLRTGQVTVNGGAFNPEAPFGGFGASGLGREFGRWGLEEFLEVRSLQL*
+
+>3FR_NODE_4#PROKKA_00164
+MLRFIVALMLLFPLVAQAEDAIKPGQWKQTIHVTIPGSSVKIPPHSSTNCVKPEQAGSIK
+SIIEEAQQPGCKLNEYSRSGNKVHWKMTCTGKSQASTEGVFTLQSKTSYHIHMNALMQTP
+NGPYKTVVDSDGKWVGPCK*
+
+>3FR_NODE_4#PROKKA_00165
+MRAPDELINGRWASEITAALPARIHQGVAQHWEADPEAEALVDHQVRWSYRELSAAVAAA
+RQWLVGQGVRPGDRLMLVSENGRALVALLLAASGLDAWAAIINARLADNEIDAIRDNCDP
+RLLIYTTEVSPDARNHAQRHDADIVHLDPLGEFAVGPAAAQSLPQPVVKDGTQVAAMIYT
+SGTTGQPKGVMLTHRAILFIARVSGGLRNLRPGRHVYGVLPSSHVFGLSSVMLGSLANGA
+CLHTVPRFEAGALLDALAGERISVLQGVPAMYARTLEYLHQHNRKLVAPALDYLSAGGAP
+LDTDLKTRVEATFGTTLHNGYGLTEASPTISQTRIGEDSEASSVGRILPGLDYEVVHLKS
+RQPVLQGEVGELRVRGPSIMRGYFRKPEATRAVLDDAGWLDTGDLARIDPDGQLHIVGRA
+KELIIRSGFNVYPPDVEAVLNEHPAVTLSAVVGRQITGNEEVVAYVQLAPGHDMTESALS
+EFAAARLSAYKRPSEIHILDQLPVTPAGKILKARLRALANQTPDR*
+
+>3FR_NODE_4#PROKKA_00166
+VIRDKETLNQLIDTISRFVRERLVPSEEQVAQDDAIPEDILQEMKDMGLFGLSIPEEYGG
+LGLTMEEEALVAMEIGRTSPAFRSIFGTNNGIGSQGILIDGTDEQKRRYIPRLATGELIS
+SFCLTEPDVGSDAGSLRTTATRDGDHYVLNGTKRYITNGPEAGLFTVMARTDPDNKGAGG
+ITAFIVEGDTPGLHRGRPDRKMGQKGAHTCDIIFDNCRVPAENIIGGREGVGFKTAMKVL
+DRGRLHISGVCVGVAERVLDDALHFAMERTQFGKPIAEHQLIQALLADSKSEAYAGRCMV
+LDAARRKDAGENVSTLASCAKLFCSEMVGRVADRAVQVHGGAGYMAEYAVERFYRDVRLF
+RIYEGTSQIQQLVIARNMVREAD*
+
+>3FR_NODE_4#PROKKA_00167
+VVDDNSDLGLDAALDPQNGAKDRKFVTALARGLEVLRAFRPGDGFLGNQEIARRTGLPKP
+TVTRLTYTLTKLGYLSYSQRLERYSLGTGALALGYATLSTFGIRQIARPLMQELADDVDA
+SVSLGARERLSMIYLENCRGSGAVTLRLDVGSRIPIATTAVGRAFLAALPEGERNYLMDH
+IKRHAGNRWPPVRRGIERAIRQYQETGFVKTVGTWERDVNAVGVPLVQSDNGNIYAFNCG
+GPSFVLPEERLDAELGPKLKQLVQNVEAALRRL*
+
+>3FR_NODE_4#PROKKA_00168
+MLDAYLYDGLRSPFGRHAGALSPLRPDDLLATVIQALIARSGFAKEQIEDIVIGCTNQAG
+EDARNVARHAGLLAGLPVETAALTVNRLCGSGLAAVADAARMITCGEGELILAGGVESMS
+RAPFVMAKAESAYSRQLRTFDSTIGARFPNPKVLAEFGSDTMPETADNVARDLGISREAA
+DAYALQSQQRYEAARQDGFYREEVLPVEVPQGRKQPPRWVSADEHPRPDTDTAKLARLSP
+LFEEGVVTAGNASGINDGAAALLIGSRSVGQRLDIKPRARILSAAAAGVPPRVMGLGPVP
+AAQKALARAGLSLNDMDIIEINEAFAAQVLGCCQQLGIAGDDPRLNPNGGAIAVGHPLGA
+SGARLTLTAMRQLERINGRYALVSLCIGVGQGVAAVIERM*
+
+>3FR_NODE_4#PROKKA_00169
+MKPFTWEDPLLLDLALDSDERMVRDSAHDYCQNKLMPRVLEANRHEVFHREIMNEMGELG
+FLGPTIPEQYGGAGVNHVCYGLIAREVERVDSSYRSAMSVQSSLVMHPIYSFGSETVKQK
+YLPKLASGEWIGCFGLTEPDHGSDPGSMITRAKKVDGGYRLSGAKTWITNSPLADVLVIW
+AKLDDTITGFVLERGMEGLETPKIEGKFSLRASVTGQIMMDDVFVPEENRLDVTGLKGPF
+SCLNKARYGISWGSMGAAEFCWHAARQYTLDRKQFNRPLAANQLIQKKLADMQTEITLGL
+HGALRLGRLMDSGDWAPEMVSLLKRNNCGKALDIARTARDMHGGNGIADEYHVIRHVMNL
+EAVNTYEGTHDVHALILGRAQTGLQAFTG*
+
+>3FR_NODE_4#PROKKA_00170
+MVERKHGGLIVAEHLQAAGISHLFALCGGHISPILVQAKALGIEVVDVRHEASAVFAADA
+MARLTGRPGVAAVTAGPGVTNTITALKNAQMAQSPVVVIGGATPTVLKNRGSLQDIDQLA
+LMKSLVKWQTSVGTLAQLDEAMRYALEVAAQGVPGPVFVEAPIDLLYPRDLVHSLYADQA
+GLDKMKGPVGRLLRGGLDLYLLRQERQPALSVHPNLKTLTEPAAEWHAARQLGEVVKRLA
+SAQRPALVLGSQVLVNRTAEQAKDIADAVERLGLPVWTGGMSRGLLGAEHDLLFRHHRGR
+ALAEADLVIVCGFPLDFRLKYGRGFAKGATLVSVNLSLHDLLLNRKPTVPVLAHPGDFLQ
+ALADRMSSRAAQWRAWLGELGKRENAREEEIDQQAAAPADKVNPLHFFRTLDRHLGEQDV
+LVVDGGDFVATGAYTLKPRGPLAWLDPGVYGTLGVGGGFTLGAAAARPGSRIWLIYGDGS
+SAYSLAEFDTYRRLGLAPIAIIGCDASWRQIAREQVEMLGDPVGTDLRDTDYHLVAEGYG
+GHGILVEHNHQIDAALAEAIKLSDAGTAVCINLRLAVSEFRKGSISM*
+
+>3FR_NODE_4#PROKKA_00171
+MGRSDVIAGLSLERLDNIERHIDRKYLKPKRLPGTLTLVARRGQVAYVKAQGLMDVERNK
+PVARDTIFRIYSMTKPVTSIAMMQLFEQGRFLLNDPVHKYIPAWKNLRVYQSGVYPQFLT
+TPTLRAMTIRDLFTHMSGLTYGFMCRTNLDAAYRELKLDGGKEMTLDLLVERLSQLPLEF
+SPGSAWNYSVATDVLGYLVQLLSDRPLDEYFREHIFDPLEMADTGFMVPESKRERFAACY
+QFDPEQGYALQDDPADSHFTRPIKFLSGGGGLVSTVDDYYRFAQALNNGGQLNGARIIGR
+KTLDFMTMNHLPGNQDLPGLSIGPFSETPYEGSGFGLGFSVKVDVAKSQTNGSVGEYGWG
+GLASTNFLVDPVEDLIMVFMTQLIPSSTYPIRQELRSIINGAIVD*
+
+>3FR_NODE_4#PROKKA_00172
+MHGLMMNRQLLISQILEYAAVNYPEQEIVSRTTEGPIHRYRYPELRDRSCQLAHALAGLG
+VTQDDRVATVAWNNYRHLEIYYAVSGMGAICHTINPRLPAEQFQFIVDHAQDQYLFVDLT
+FVPLLEKLHPQLNSIKGYIIMTDEAHMPETGLPNAHCYETLIKDQPTRYDWPEFDENQAS
+SLCYTSGTTGNPKGVLYSHRSTLLHAFSVMAFPGVDFGEESSLLPVVPMFHVNAWGMPYF
+ALITGSKLVFPGPRLDGASLAELINSEGVTDAWGVPTVWLGLLRHMNESGERFSKLEHVQ
+IGGSAAPRAMINEFQERYGVEAIQGWGMTEMSPVGSVSQPTPFMRERMSAEEQLTVRGKQ
+GRALFGVEMKIVDADGKALPRDGKARGELLVRGPAITSGYYRNDEANAKAFDDEGWFRTG
+DVATIDPDGYMEIVDRVKDVIKSGGEWISSIDLENEAVGHPEVAEAAVIGVRHSKWAERP
+LLVVVRNPDSAVTAEAIVEYLSERVPKWWLPNDVVFVDELPHSATGKLQKTKLRDDFKDH
+RFSDDEA*
+
+>3FR_NODE_4#PROKKA_00173
+MTQNPDQKAPIWKRPATVEALNAHAKNTMVEHLAIEYLELGPDFLRARMPVDKRTHQPFG
+LLHGGASVALAETLGSVGANLCIADPDKAGVGLEINANHIRSARSGWVYGTARPFHIGGA
+TQVWEIRIQDEQDRLICISRITMAIVSAR*
+
+>3FR_NODE_4#PROKKA_00174
+MKQMQNRVAVITGAASGFGLEFARVGAARGMKLVLADVQAEPLEQARAEMEAAGAEVLAM
+LCDVRKSEQVQALADKTMERFGTVHLVFNNAGVGSGGLVWENTEQDWEWVLGVNLWGVIH
+GVRIFTPLMLEAARRETDYEGHIVNTASMAGLLCPPTMAVYNVSKHAVVALSETLYQDLK
+LVNAPISASVLCPYFVPTGISDSHRNRPAELQNDSGPTASQMIAQAMSQKAVSSGKVSAA
+EVAQRTFEAIGEDRFYIYSHPEALGNVKHRMEDIVAGRNPGDPFAEAPQIGQMLRDKLQG
+*
+
+>3FR_NODE_4#PROKKA_00175
+MGELVDVYRNSVQTWECDQMGHMNVQFYLDKADAGLLALTRMLGLNRRFLNERQARVRVL
+ENHVRFLREQHAGSPLTLRAGLIDIRPDQLKLYFELTNPIQQAVAASFITQAVLESTAGK
+DHLTLPQSALEKAQQYQIDWPRPEGPMGLESTPPRTPPTLQEADDLGMMPTYLGAVSAGM
+CDADGHLAIRSYMGIVSDAVPHLLSRIRHDTREVPRPGGAALEYRWIYHQRPEQGDLVTL
+RSAITHLGNKAYRLGHWLFDAETGHCLATTEAVAVMMDLDERKALVIPQTARASLEEMLV
+KGFSI*
+
+>3FR_NODE_4#PROKKA_00176
+MKAGMVAPLDATQQSRLRVLLALFGLVWLINAGFQAVAWLAAPNASTHFIHALAKSTTVV
+PRWVQPLLMTGLHSAQSLGLGIVAAIMVLLAILLGLALLTQRKVAFAARVGIIYSIICWI
+FLDGFGFPYANGQTDPGVFVAYAIAFLFVLSVAPVFDREGTKAPEIDERLWHWARIAFGL
+LWLFDAVLKWIPPFLLHFSSQITSVIPGQPHWIAAWLSFVAELVHAIGPIPVAVVVALAE
+TAIAIGLLSGRWMRLVIPVGMLYSVAVWTTAEAFGGPYSTAGTGVRGNVLGNVLIYLIPF
+LFLWVGNSSQRSAAETTGRTLTD*
+
+>3FR_NODE_4#PROKKA_00177
+MVKKAPEVDVPSAKDRNFVTALARGLELLRAFGPEDDYLGNAELAERTGIPRPTVSRLTY
+TLIELGYLRYCERLEKYRLGAGVLALGYRYLSRMGLRELARGPMQALADRTDCLVALGTA
+DRLDMTYVETCQGAGPLVLRLEVGSRIPMATSAMGRAYLAALPDARRNEYREKIREVYTD
+DYEAIWQGVEQGVEQYQKLGFCTALSDWNPHIAGVGVPLVLDGGSQIMAFNCGGAAMRLS
+RSVLEKKLGPQLVEVVAEVQRQMHGRRLEAVS*
+
+>3FR_NODE_4#PROKKA_00178
+MQRRYLATLLAGLMAVPAVAVADSGSSSSMPDMNIKLHAHLHGSVDFSNTGGRAVPNTEA
+YGEAAGTPARATNLSNNNSTIGFTGQHLVPGAFMAIFQVELALPGSETGVNNSYGKGNHV
+SKNVGLHDTYFGIANPLGTLLFQPSFENQGAYLSRPFNMFKDTVGDFNSIIDTANFPNGG
+PNGLPAISFAGQANYAISYASPKVKGFDAVLSYTEDANGGDFGTNNTYGSGYCAGTPNTN
+HYPNCYGYPNANQHNNAWSFGVQYENEFSSLQSKVNGLINYSQINVQGNTSGVPLGGFTF
+ADATQPNQTPPSSKLQLKALELAGKWDYEPTGTTAIAVWERSTGLYSRDAYSLGFSQAVP
+GNNDLMVSWIHAGNLSSPLANICDPTKTVCSGSEVKQSGANEYVAGIKHHFDKQVSAYLI
+YAYTRNNAEGLYGLGGPNHGQSVYPLNPGDNPQSLSLGMTWDF*
+
+>3FR_NODE_4#PROKKA_00179
+MFDRHHQVWPEFAPLHLTLPETSICYNLEVTAHRYPHKDAIIFYDRRISYGEFQRQVEIL
+AGFLAREMGVEKGDRVLLYMQNSPQWMIAYYAILRANAVVVPVNPMNRRGELEHYASDTQ
+ARVILCAQELFDQVSPLLGEEGLSRAVVAAYSEYLPDQTDLPLPDAVSEPARAINQSGVV
+PWRQALAGEPAAPKALVGPEDHCVFPYTSGTTGAPKGCIHTHQSVMATLVGAVAWNPATA
+DSVTLVSLPLFHVTGMQVSMNAPIFVGATMVIMTRWDRRVAGALIERYGVTEWRNIVTMV
+IDFLSDPEARNYDLSSLRAIGGGGAAMPKAIAERLHEMTGLTYIEGYGLSETIAATHVNP
+VDNPRAQCLGIPVFDVDCRVLDVASGQQQDVGEVGEIVINGPQVFKGYWNRPQATAEAFT
+EVDGKSFFRTGDLGYYDEQGYFYLVDRVKRMINASGYKVWPAEVESMMYQHPAIRESCVI
+SAPDERRGETVKAVVVLTDDAPADVTEAAIQQWCQDNMAAYKVPRIIEFRDSLPRSATGK
+IQWRVLQEEERERAAG*
+
+>3FR_NODE_4#PROKKA_00180
+MQYSSDEISNSGLDRPRAGGYRLRLALSGLGWGSTALMFALLALALIAIIAFVVIRGGAH
+VNWATLSQTTQGYHGLLNAIEGTLLVTVGSLLIAAPVGVVTGIYLSEYQHRRSARFFSFL
+CDVMIGVPSIVLGMFGYIAMVNFFGWQFSLLAGCITLSFMIMPYIARTSELALLQVPNSV
+REAAYALGAGDRVVIFRVVLASCVPQILNGLLFAAAISMGETAPLIYTLGWSNYMWGGEF
+FHHPVGYLTYVIWSFISEPSSAAHQLAYVAALLTTGFALLINILARSTIRKQSQHQSQ*
+
+>3FR_NODE_4#PROKKA_00181
+MKTNRLFRWSITGIASVIPLALLAIFIFLLINSWPAIKFSGWHFLTGSQWSLGNEYGDLV
+TVNGQEVPPGADYGIGFLIAGTLLSSFLALLIALPISVAASAFLAEAVPKRLQNTLALFV
+ELLAGVPSVVFGLWGLVVLVPFMNHYIYPGLVHVLGDVPFFQPPTGAGYGLLTSSVVLAV
+MIAPLITSTVRGAIERVPMVQREAGLALGATRFEVLWKTVLPSVRRVVIGAGILALGRAL
+GETMAVLMVSGNALGYLPHNIYSPISTMAAFIVSQLDSALEDASGMATHALSEIALILFF
+ITLIVNVIARLLLWLARD*
+
+>3FR_NODE_4#PROKKA_00182
+MKGKFSLKSTRTGSMMAKGALAAALLTAGMGVANASTTLQETGSSLLYPLFNQWIPAYSK
+AHSDIQVNAASTGSGTGIAQSIAGNVQMGGSDAYLSGAMMKKHSDMLNIPVAISSQMVNY
+NVPGLNDKHLKLSGPVLSRIYEGTVKYWDNKEIKAMNPGVDLPHHRIVPVHRSDGSGDTF
+LFTQYLSFSHPYWHKKLGYGTTVNWPAVQGEIGATGNPGMVQALKDNPYSVAYIGVSYKG
+QIDKDNLGEAMLKNKAGNFVLPNSTTVPAAAAAMVPKTPKDERISLIFAPGAKSYPIINY
+EYVIMHANQGDLAAPLKQFLNWAVSPNGGNASQYLGAVNFMPLPKKAEELTKAQIAKIHS
+*
+
+>3FR_NODE_4#PROKKA_00183
+MGTTFRPYSPDQELLLPPSLNEWLPEGHLAYFVSDVVEELDLSALYARYDGDGRRNSPFD
+PRMMLKVLIYAYATGTFSSRKIARKLEEDVAFRVLAAGNFPRHRTICDFRKQHLAAFKAV
+FIQVVRIAQEAELITLGTLAIDGTKVRANASKHKAMSYGRMQEEEKRLSKEVDELCRQAR
+RTDEEEDQQFGPDQRGDELPEELQHRQARLDKIRAAKEKLEADQKERDKARGRSPDDDRR
+SPRGGRNFKRDYGVPDDKDQSNFTDPQSRIMKTSDGFQQCYNGQLAVDGEFQLIVANHQG
+SNPSDNGCLLPLLNDVKDTLGTYPRQCLADAGYRKEGDLQTLEVNGIDGYVSLRREGRKP
+GEIDATRYPATARMAEKLATAAGRSVYGQRKHLVEAVNGWIKHVLGFRQFSLRGLNAVQG
+EWDLVCLSLNLRRMSTLMRMV*
+
+>3FR_NODE_4#PROKKA_00184
+MTMITPSYLGETIEYSSLHACRSTLEDPTRKQPRNTSTNISMRPGEEDKDPLGDFLASLE
+RLSALPENIRVLPSHGLVFEGLHQRLKALQRHHELQIDRLLERCEHPQSARDVLSLMFRR
+PLDEHAILFAMGESIAHLHHLRLQGKLSQVEQAPFRYIRN*
+
+>3FR_NODE_4#PROKKA_00185
+MEAITNGMMNLNRQRHQHLVALRIIFAHGENGGEEVVHIGHVAIKTGDTFPGTGRVDLLC
+LTHCLTSTD*
+
+>6FR_NODE_12#PROKKA_00186
+MTAPRWSATRASASSQSSRAPPGREACSCRRPSSRRRRAGSSSRARPREPPLMAALRRAS
+WGSSPRRVSSSTTSSGSRGEKFTRRQRLTRVGSTSRGSCTVSTRMLLGGGSSRVLSRAPE
+LARLSRPASRITTMRQPPPKGAKLSVRITSRTCSTLIWAEGESEGGSTTKKSSWLPAARR
+RQGPQAPQGVSPGSWQLAAANRARAVVVRPTPRGPTKR*
+
+>6FR_NODE_12#PROKKA_00187
+MKRAPFITLEGGEGCGKSTHASLLAQRIRELGLPALLTHEPGATELGGALRRLLADPAGP
+DPCPQAELLLYLADRAQHLEQVIRPALAAGEAVVCDRFADSTQVYQGLARGLGADRVREL
+NRWLCGDTWPDLTIVLDLDPALGLARARHRQGKQGLDRLEQAGGEFHRLVREGFLELARQ
+EPERVRLIEAAGSRPEVARRIWEVARPLLESWRKTREA*
+
+>6FR_NODE_12#PROKKA_00188
+VQFVQSSYPLAGLWRPGQETPPASGDTSGSGGVSGGAGFARMLDGKLRQGEPADLSTGAT
+RQTGGPVRYSPHSPLLVGASIGAAPGLFTAPVVWSDPTPAAPKGAYRMHSANPRSTFPLR
+TVPPPPAPPPSSEHENEDVGLPSAISTYHGSRFRAEVQVGERQEVNADVEQFHFPHLVQK
+NGLTYAYFIDHSHGSENDVGLAVSKDGVNFQYQGKVLTKGPEGFDAQMASFPAVQYDGET
+NTWYMLYEAKADHDDLNTVCLATSPDGRNWTKHGPVIEPGDAGEISAVDVGTPTMFKEGG
+QWHVYFHTLAKDGRVRIGYAHGENLQDLTVNQGPLLDVDPQGIEGGTVGARSNVVKVGDF
+YYMAYEVCSPNTDFHRSQWGTNLARASSPGGPWVKMSGRPLLVNDRPGMGMDGPELSLQD
+GKLYLYYRHGANATARVELSGLGDSSKMYLAHQSSPGVPV*
+
+>6FR_NODE_12#PROKKA_00189
+MSKLFGILAGLIGIFLLVASVISFGHLVEDAWVRGGMLASLLFALLLLLGSAAFLLTAVL
+LFRMRSHYLPRLYELEELEGLEEPPPKTKDSGESNGPRLA*
+
+>6FR_NODE_12#PROKKA_00190
+MEARTLFNGALGVKAHVRGLESVSDNIANVNTYGYKATRAQFSDLLYQEMAGGAGFPQQV
+GNGALTAVENMMMQAPLEPTENVLDMAINGRGFFTVKHPDRNEGNRYTRAGQFYLDKDYF
+LVNSEGYRVQGFAVDADGNVNVNQVQDIQIDNQIQDATATTSVDLAVNLDASDTTEFRQA
+VAIDPTDSGTYNFRMGFQVVDEDGDTQDIAVFYQKLESYTGDAPAGSQSVWKAATFHNDS
+GTLTADPSYPDNTFFLHFDTNGQLVGVTTGTPATGDSYTSNAEVSSTSASVSDRLGETFA
+YTGAGNTQTLRSTATITFSGTTTAGDTVTIGGTNYTFAALSPSDAAAWLADQINANSAGS
+YYAQDDASGTVTLYAKDGTAAAEVSASSVVISTDDTMSLTELVNTVDSGRKATGSLFVNI
+AGLTAGSSTVTVAGHTFTYGPAQDFTTLSELTTLINDLSEVDATSSGHNIYITAASVGTS
+GNSLGLATNDAANVAVSASTLLNGLDDSDATNIDASATTGSGGGQALKLDRTDVGASATI
+DVATTNTLGSNLGLDFTGGNFTQNSTASDGNGTSNTTGEVPLTFTFTKSGSTLTQQVTLD
+YSPTDGDDSTMLAGDYETFYLKTDGRGTGYLKYLEIDDQGLITAHYTNGQGVPQAALALT
+TFIAPQELLREGDNLWRATAAAGVPTVAQAGDAQTAMGEVKSYALELSTVDLAQEFVNLI
+NYQRSFQANSKSIITGDEMLKTAINLKG*
+
+>6FR_NODE_12#PROKKA_00191
+MDHAALPQTLAPGLYRLGSYHLACFLVETPDAALLFETGMSLVAPLILAQLDELGVPREK
+IRWIVHSHAHSDHSTGQAALLEALPRAELLLSPTSRRHLAKPSTAEQFAKEDDSTRRALE
+RIGALPPGSLPDPLPLLPARHRTVEPGDTLDLGGLTVELRSAAGHVPGGLLAWLPELGAF
+LASDSAGFHMAARPNYPLYFTGYREYLRTLEEIRRTNPELLCLGHQGWFRGGEARRYLEA
+LKAHLAFEHATIWEAHRRGEDEESQARRLVERYYHDELAIYPRDILWYCCRLLVRRSLEA
+GA*
+
+>6FR_NODE_12#PROKKA_00192
+VNYEPCVKHKVVRNTVRDFAEAELRPIAHEVDQNSRFPWEVVEKMRGLQYFGLQAPRELG
+GAGLDSISYAIAIEELSRVCAGIGLCVTVHNSVALYPLLKFGSPEQIERLALDLISGRRI
+GAFCLTEAGAGSDAGAVETLALPCDEGYLINGTKIFVTNGGVCGLALIFAKTDLDHPRGA
+PSVLMVEKERSGFAVGEIEDLSGMRCNPVSSLFLEDCLVPPENLLGRRGDGLRIGLSALD
+TGRLGIAAQALGIAQGAFEAAVRYAKERQQFGKPIARFQTIQNYLADMATKIDAARMLLY
+RACAAKDQGQPFSAEAAKAKLFCSATAREVCNLAVQIHGGYGYSKEYEVERYYRDAKVTE
+LYEGTSEVQRMVIARAILSAPA*
+
+>6FR_NODE_12#PROKKA_00193
+MKLVVFLKQVPGVTEIPWDPASGHLRREKAPGMMNPACRHALEAALILKEQHGGELTAIS
+MGPPAAEEILREALALGADRAVLLSDPRLAGADTPATSYTLSLAVRAVCPDCDLLLLGNQ
+TSDSETGQVGPHLAEELDLPSAINVEELELDGEVLRVKRLCDNFLETLEMDLPALVTINT
+QGHPPRQVPLGGVEDAFSRGEFLVLNAEDLKADLARVGMTGSAGRIVKVYPAGGERKGEL
+IKGAPKRCVLELLERHGDLLGGYLRKDLGGGR*
+
+>6FR_NODE_12#PROKKA_00194
+MSRRQQENGAVWVFGDYRNYFQNRVTLQLLARARDLASHLDTKVAVVVMGYRVGRWVREY
+VAHGADVVYVLDHPSLKYYLVQTYTRLMERLAGEHQPQIILVGATGFGKELAARLASRLG
+TGLTADCVDLTVDDQGRFIQTAPSFGGNLLAQIMIPQARPQMATVRPGTFQELPHDADRR
+GEIIKLPLPDDLPPEKARLIHSRRIKPRRRKLEKARVVICGGRGMGSKKKFKNLYALARL
+LGAQVGATRPVVYQGWAPEDALVGQAGRDVHPEVLFSFGVSGAIQHTAGIHDAQFIVAVN
+KNPAAQMMKMADVAIAADANQVCLALIRELKARLEKKK*
+
+>6FR_NODE_12#PROKKA_00195
+VNYTDPQELLPVVDAQDRVIGTMTRQEIHAKGLLHRAAHVLLFDPAGRLYLQKRSAAKDT
+YPGKWTSSASGHVDPAESYAQCAARELAEELGLEAELRPLGRLPAGPRTENEFVEIFTGV
+SAEPPRPNPQEIETGRFFTPAQALKLAADPTRACPSLGAVLELWQELEGD*
+
+>6FR_NODE_12#PROKKA_00196
+MESEVLQRVAEMLRSPGAVARNRNLLEFESEAGQRAWRCYRLFLSLLAELERAAQSPEVR
+VSAQETEGGLQLVLVDPRVSYRRSCLVPPELVELFLDKLTALGLLGGEKT*
+
+>6FR_NODE_12#PROKKA_00197
+VSRPRYVRTQRHGPVTVVVMDNPATMNAMDQDMGPRLVGALESLAADRSVRAVVLTGAGG
+RFSAGGNLTRAEEFLEENPGRGAAPVFAQYTIWVHRLLAVLTRLPQPVVAAVERAASGGG
+LGWLLACDLVVLAEDARLSTGFLAIGLAPAAGVSWHLPRLVGLPRAAELLMLGRTLGADR
+ALELGLADQLTPPGGTLEAALELAGELARGPAQALAATKQLLGGAARRGLFPQAEAERRA
+VLHTADQEEFARRLERFRQRRRRS*
+
+>6FR_NODE_12#PROKKA_00198
+MPMDWTPPPRGGGREPDINQVVQNLKNRLPVFKKARGLWLAVAVVLAIILGASSYYTCS*
+
+>7FR_NODE_8#PROKKA_00199
+MMYGDSSAGAGIEAQSLLCPRCGKAQPVRKKLLLVLPEGDKYAYFCAVCGEEVGSKLEES
+QGGPSFIPR*
+
+>7FR_NODE_8#PROKKA_00200
+MRSIVIDELSSPDVDRLSEHLDQTLTPSGLSGVYWLELPEDLLLPLQQEHRQSCGPHRVA
+VVVEEGCLRLELLVRAQESLRCNCTAYASSAQRDFLLDYLDRLIEELGLRT*
+
+>7FR_NODE_8#PROKKA_00201
+MSLPKRITAPLLSGLVLPGLGQLINRQLGKGALLICLMSLFFMSFLFLTVYQVSHAMSAL
+GEAAAQSADKWQALRAQLARQGTGWLWGLGTAGLGIWLFAVIDAARVGARLNRSGAEGGQ
+GES*
+
+>7FR_NODE_8#PROKKA_00202
+VVMEEYQKTLARLLAESGGLFFQEGLRLKDGRPTPYFVNLGVFRTGRLALELGRCFSLWI
+HHHGLDQDLDCIVGPSYKGSAIAQATAIALYELHGKEVAYDYDRKEAKTHGEATGHGYLF
+VTGAALQGGKVLIIDDVGTSMSTKLELLKKLSWLKPRLERPMELLGVVLAVDREQTQAVY
+DAQGRVREGVRGPDAMESFRQESGLEVWSLLGIRQALDYLYKEGIPVLIQGEMRPLDELT
+MQIAREYLELYGREEA*
+
+>7FR_NODE_8#PROKKA_00203
+LNRSLQNQISARYWSSHISSRNNIQNNENCACDPRLAPCLLVCRASLIPFLPFLEGAKLK
+KLGAFYLGRRRRLQAGKHAGSSRHQSGPGAPRRFLFGGNCDPPWRATHPPPRRQGRPAGR
+PLSTMQNKPGKGITLLSSRPPAVPPRRGRSPAAPPSPWRPAWP*
+
+>7FR_NODE_8#PROKKA_00204
+MVALVGGLAALILGIIGLIGWWDEFIWLLKGAIPPILILGGVLAAYLGLEEMKDKRQAED
+ESAREPFTPEEQDVDKYKREVEELKAKLAAMEKEEQQDSSPAEEAPQEDEKKEE*
+
+>7FR_NODE_8#PROKKA_00205
+VSRDWFPAKVRFMSGGRAQQTPLAIRVEGRWLEVRLLGEELVAPESGLAYVRRYRLEDRR
+GRRWELRQRQEGWFCRELH*
+
+>7FR_NODE_8#PROKKA_00206
+MDQSKALAKYREFRPAWKSFLPYFLGVVIFTVGPRVNPQAPISPDLSHLIATCFLAFILI
+TRFSNLYELADGRLGWRRSFPRALERQAPVEQITRIDLRRGIFHRLAGVAHVHVYLENQQ
+EPYLKLFGVSEPEELRRLLLDLGASDQRVTGAWRK*
+
+>7FR_NODE_8#PROKKA_00207
+MALLVSFFGKGRRGACLLGLLGLLLLAPPAVAAGAGYVVAPVNKGADLRLLPSEAWPPPE
+GSRADILIKLAYLRGIMDALQYLELAPRSAERVLNAYQGLSLQDLAARIDAFYLTDPRRR
+DLPPAVVLFRLLAPAGKDAPAVKGPARPGGQGGRSGK*
+
+>7FR_NODE_8#PROKKA_00208
+MQRSSGSITQLARLVESLAELLRLHYGPDGLPAAQEEDLCSQEVEGRRLGELLAELWPDS
+GPWRGPCLGQGAIRETERLLRYRLQQAEAQNRALATRLERVRRQVAAQRRTLLEQLRAAR
+LQVEQGQARLEALSAELGGLRAELERRRERARRRRRYLEGVVPRGMNRFADAGGRILDQA
+TLRRATRELRELQALVVRTKDACARLEHRWARARLELARARSHEAGLRAELARLEPYWQA
+KTHRLARAKVVLAARQEELGPLERNLHRLRVMGLAHAEVVSRGRAALEPLLAPLASGESP
+DPVESLEESLTQAGEQARRGRRLTALMERLGRRLERRLEAIGPVLKEQRRLNKEITRLEN
+ELPGLLEPLLAGDGADPRNRQEAGARFSLLIARLEDLIPQARATQEQLDELRQALTIGLS
+RGKAWQAAWRRAGKAERAALHQAQALVEEVRLAARQAARQAEHLRRRAEPAVKALSPLRS
+QDLLPSLAALAQGVSRGQLKARQLEARAAELEGRIPRPYFGNLSKPPVALKPVSAGLRRL
+SGKQVELERLAALERAARRWQGLLDGPLVEEIRRPVEQVALRLARSLTLLERQKNLLASR
+HQKQGRELSTLKAELDQRRRREELARRRLEQVRDRNRRQQRTIRNYETELKQAQTRAALA
+QRLEDELARLGEHAQTLARRLERSDKLAAALKRKSLERHRLYRRSQYAVEWLDYWRERAL
+EQEKLLSSARAELELARREYQQARSLLASAVSERDQALKELATERAARARQALDLLGGKA
+LSVELAASRSEAGRWAKLAQDMALALAASGEHHRQETADLRAQVDQLSAEAAMLKRQLER
+IAAMVEVQVPGLEELADLPPAPSWRRPVALRLVPLGPKQVAQALDRLSAARRRLQNLGRG
+TLGHWALIAALTCGLVLTPPGTPSKATRADAPLKPPRPVLRHLAQGSPLTPIYQVPAQAR
+LLGDKVARGSLELNLLPLRGQPVAVPQSVKRRLKELAREAGLSPKVLLTSARALYAGQAA
+VDPSALEELAHTARQLARRHPLIFRELSRRGLPPAASAVAALAPEPEKAQHLFLDRLYRE
+YRSLGFSAEEALGALAANQRAFHRLTRQWTPPRRFIGKVQPVEAVEKMGLREFLQKITPY
+IQSKLKVFLRQRGMSYSGDLTLYAKNLAFDMYCAAKKFQVPVTLLLAIAHQETWYANVLG
+DANRSASPFQIYEPTRELIIKSMAEAGFVPPPKRIKLQRHLTMATFMASFHLRELMQRAY
+TPPRRGRQAVVNLDRVLQRYNGSSRYAAQVALRKRQLARFLRRQG*
+
+>7FR_NODE_8#PROKKA_00209
+MIGKRIRLERVMDRGTRRTVLVPLVHGVGMGPIEGITDVLNTVDTISMGGANAVVLHKGI
+VAAGHRRGGADIGLVIHLSATCADGSQTLVTEVEEAVCLGADAVSLRIEVGGADEDESLA
+LLGAVSRVAADWGMPLLALMNPAPIPPAKMPKLLMRAARIGAELGADVVLVPYHKRFAEV
+VAATPVPVVAIGGVKKTPPKQMLEMARAAVDAGAYGVSVGRTVFQYEKPGNMIKAICQVV
+HRKATVKKAMEILAKKPIESTLYGGTVIW*
+
+>7FR_NODE_8#PROKKA_00210
+LTTLETLGRFAAGLKADELPPRLGEAVNRCLIDLLGAACAGHGSGAARMVRAVAGPLFAA
+GPAWLWFSGRRLASPGAALANAAAASAWDLDDGHRAAAGHPGAAIIPACLAAAQETGASA
+RELEAALVLGYEVACRVAAARDLARLPTMASGRWVAYGVAAAAGRLHGLDAAGLAQAMAV
+AGVLSPDLAAAGYSRLMGNLVKEGIPWATLTGLVAVKLAAHGFSGPLDILDHPDYYQAPG
+ITAGLGGGQWAIEQVYFKPYACCRWCHAAIDALLALQDEQGLDADEIAEIQVHTFERALR
+LSNETGPATLEGAQYSLPFTLAVAAVEGAAGLLPLRPELLGREDLVELAGRVRLEVDPEL
+EAMFPERSPARVVAMTRSGRRHEHTVLDPLGDPANPLSTARLEEKFRALTAGLLPPSRQQ
+ALLVRIHALEPEGLPPLLEELGRPLQPEK*
+
+>7FR_NODE_8#PROKKA_00211
+VARLSEDERRIRRMVGSRIRELRQALDLRATELASRAGISQSQLSKLENGKAAISIPVLT
+SLCRVLDRPLSYLFQKEEEIPRVLGTMTTVSGPENRGLEWFAAEVNRRSGGRMSIIPLWA
+TMLGSAPDQVAMLRQGVIDLFIEELIFYQHIAPAVKLISLPYVFADDAHLLSFLESPFFQ
+ERVHGPLTKSGIRILNRRWNWRRGLERVLVARQPVTRPEEVKGLKVRIFDSPALARFWEE
+LGARPVVVPWPRVREAWEAGEFDLLPTHRSHLYPLGFCRQGRFVTLLGDVPPALAVTVNE
+QKYLSLPPAVQAALEESCDAAGGFFSIEIRRAEVDNQAANLAEYGAVYLKVDLEPWRRAA
+GRVVERMAREGAVDLDAWQAVQELRPAGEGA*
+
+>7FR_NODE_8#PROKKA_00212
+MSNRDIHNATGDSVKMNALVLGAGLQGKAVIHDLSRSELVDRILVADLDLAAAQRFLDKG
+GYHKVRAVQADALDPAVLRRLISENRSDIVVCMLPAHLSGRIAEVCVECGVPFVNTSYAQ
+WLGELDQRARDKGVILLPEMGFDPGIDLIVGRMALDELDQVEGFYSYGGGLPDPAACDNP
+LKYKITWTFDGVLKAYCRPARLLRQGRPVEIPGDEIFQEENIHFIEVPELGRLEAYPNGD
+ATRFVEVFGLGPELKEMGRFATRWPGHSAFWRIMAKLGFLGDQPVELGEGVSVSPREFLV
+KLLEPRLQFRENERDVVVLRVKVWGRRGGRKRTVTYDLVDYRDLATGLFAMNRTVGFAAS
+IGAQMVLKGEITGAGVLSPVKVVDGQRFLDELAARGIKVQRRLEEE*
+
+>7FR_NODE_8#PROKKA_00213
+MTLRVAALVPTLRLWADTLTELKRSRSAVVGGIMLALIVGISLTFPLYYPVDPLAQDLMA
+RLTPPAWQAGGSLAHPLGTDNLGRDVLARILYGSRVSLLVGFASVLVAEALGIVLGLLSG
+YYGGRTDSIIMRIADVFMAYPFMLLTISIIAVLGNSIFNLILVLGVSDWVTYARTVRGSV
+LALKEKEFVKAAHSLGTRNRTIIRRHILPNILSPLLVLGTVRVANIIIWESGLSFLGMGV
+PPPQPTWGRMLAEGRAYITDAWWLVTLPGLAIMLTILAINLLGDGLRDALDPRLRNV*
+
+>7FR_NODE_8#PROKKA_00214
+MGRYILKRLWHTVYVVVGISVIAFFFIHLSGDPVMLMLPADASHQEIEELRQQLGFNDPL
+YVQYWRFATKAVQGDFGESLYYHVPAMELILERLPASLELALAAMAIALVVAIPLGILSA
+VKRGSFIDLGSMLGALFGLSMPHFWLGIMLILLFSVKLGWLPTSGRGGWEHLIMPSLALG
+MSLMAMFARLTRSVMLEVLGQDYVRTARAKGLKERLVIGKHALKNALIPLVTVAGMQFGF
+LIGGTVIIETVFAWPGVGRLVVQAIFNRDYPLVQATVLVLAVLFVLVNLLVDLLYVYLDP
+QISYLEEK*
+
+>7FR_NODE_8#PROKKA_00215
+MKKFKRLCLALGVAALGLAILAGPALAKKDVLVVIQEAEPVGLDLMTSSIQTTMSVCYNI
+HDTLFAPQEDASVKPRLAESWEKVDDLTWKIHLRRDATFHNGEPVNAQAVKFSFERSFKP
+SIKNPHKGKLSAFKEVKVLDDYTLLISTKEPYAPGLYILGYYLPIVPPGYIKKVGDAKYN
+TNPIGCGPYKLEKWVRGEEIVLTAYDKYYGPKPAFKKVIFKGVPEEASRIAALLTGEADV
+ISGVSIHQRKRILASGKAYLTNQMGVMPYLGLNTYKPPFNDVRVRQAMNYAVNRELINKA
+LFGGKAILCAGPISPRTFGHDPNLKPYPYDPAKAKKLLAEAGYPNGFQTRLAYPTYMSQI
+QEQAEAIAADLAKVGVKVRLEPYERAVMWQRYKARKHAMYIYWWDDAPEPDRYMYSLFNS
+KVRDYYYKNPEVDKLLDLGRTILDRKKRAEVYHKIDRLLYNDAPWVYLYVIPEVFAVSNQ
+VAYQGRRDGFLDMRTAKPK*
+
+>7FR_NODE_8#PROKKA_00216
+VAEVLRVKELVKHFPVRQGFFGRRQGVVHAVDGVSFTLEENQTLGLVGESGCGKSTIAFC
+LLRLIDPTAGEVWFQGRNLAAAGSEELRRLRRDIQIVFQDPFGSLNPRMTVAQIVEEPLL
+NHLELSAARRRELVAEGLSMVGLLPEHAQRFPHEFSGGQRQRICLARALVLRPKVIICDE
+PVSALDVSVQAQVLNLLSRLQRQLGLSYIFVSHDLAVIRYVSQRVAVMYLGRIVEQAGVK
+ELYARPMHPYTQALLSAVPVPNPRRRRRRIILEGDVPRPLDPPSGCHFHPRCGRAMEICR
+HQAPELRPLADGHLVACHLYDEVRSAPGGTVEGG*
+
+>7FR_NODE_8#PROKKA_00217
+VARAVDGVDLTVGRGEILGLVGESGCGKSALALSVLRLLPMPPAFFAGGQIRFKGRDLLK
+MDPEELRRLRGNQISMIFQEPMTALNPVFTIGNQLGEVFRVHQGLARREARRRAVEMLEM
+VGVPAPARRVREYPYQLSGGMRQRVMIAMALACRPALLLADEPTTALDVTIQAQILELIL
+ELRDELGTAVVLITHDLGVVAETTERLAVMYTGRIVEQAPTVELFDHPLHPYTRGLLEAI
+PSAEAELADKELHEIRGVVPSLLDLPPGCNFAPRCHLADERCARQEPELVEVRPGHRVAC
+WRVDRG*
+
+>7FR_NODE_8#PROKKA_00218
+MTLMVDVALAAPLWQPLTYAVPAELAPLVKPLSRLLVPLRGGARLGFALGEPLAAGGGQD
+ALKPVLDVLEDGKGPQVWPPELLPFFQRAAAYYHVPLGQVLAWCLPAGMGSARPAKALAP
+KTQQVAVESWRRGEDSRLPRPESQAARILRRLKARGPLPLPELREEFPRAAALCRDLEKR
+GWVTISHRPLVKDLLGRPLLPEPEPEHYTPDQQRALDELLPAVHSGGFKSFLLHGVTGSG
+KTELYMACVKAALEAGRTALLLTPEIGLCLRLEGLLRQRFGAGQVAVLHSGLSPAARRGQ
+WLAIARGRARVVVGARSAVFAPLREPGVICVDEEQDEAYKQEDRFRYHARDLALLRGREQ
+DCPVVLGTATPAVTTYHRAQEGNTVCLRLPRRVREAPLPRMELVDLRREGRLVGGFLSRR
+LLAALEQTLEAGEQAILFLNRRGFAPAYLCTACGQTVGCPACAVSLTLHQGSDRLVCHVC
+GHQRPRPRSCPACGAGEEKLRPLGLGTEAVAQKLGELLPGARIARLDRDTADDPRRLGEL
+LRAIAERRVEVVVGTQMITKGHDFPGIGLVGVLSADQALALPDFRAGERAYGLLTQVAGR
+AGRQGGKSRVIVQAYDPDHHALRAALAQRPDEFYQTELAERRALGYPPFMRLVALRLEAV
+DDRRCQRAAQALAAGLEEARRRLEPGARVLGPAPAALPRAKARHRWMILLKAPTAAAAGR
+TLRLGLHRSPPLPAGVRLLVDVDPVSLI*
+
+>7FR_NODE_8#PROKKA_00219
+LALHTMAYLAAHPGRLISNRVIARDLGVSAAHLSKVLQRLARAGLLESLRGPTGGFRLGR
+PAGEISLMEVYEAIDGKFQPSSCLLGRPVCRGGKCVLGELGRNLERQTREYLLNTKLSEF
+EDFMCFEEGN*
+
+>7FR_NODE_8#PROKKA_00220
+MPLGKGRGGALPWDPRAEAALGRVPFFVRSLVRRKVEERVAEAGGRRVGLEDFQEAEAAF
+RAVRAGKSQKELEAMLPAENRPGVEMVVVQACRSRLSNCPNPLIDTQKWLERVQAWVEEL
+DLSERLRRRVADDKILFHHKLKIAIAGCPNGCSRPQIADLALVGMTRPRLVEPEVCTACG
+ACAEACPDGAVSQDDGPPEFHRELCQGCLSCSRACPVGGIELDPPGVRVLMAGKLGRHPH
+LARPVMEATGPEPVLAYWTRELEEYLASAPPGRRFSAWWLEQHPAG*
+
+>7FR_NODE_8#PROKKA_00221
+MPIPGRLLTTAMAVMPHTDVDQALASALSLDIPFWPQLPRVNYYEDMYVQASEHFPGMVV
+DHKERTLVFSMDKFMVELEETLAHLEEPEYFDISPEYSVVYHRFLELELADRPAIRGQLE
+GPISFGLNVKDQDDRPILFDDTVRPFLLEVMARRVNVQLTRLKARNPNAFMFVDEPGLQF
+IFSGLSGYSDRKAKEDLDQFFAAIERPRGIHLCGNPDWDFLLNLDLDILSLDVYSNGEVF
+SSYARSIKRFLDRGGVLAWGLVPTNFEPFSAEDHVSLKARLKEIWSALESKGVDRELMLE
+RSLLSPATCCLVNPDGEKTVDKAFALVRALSAELRDEYGLDG*
+
+>7FR_NODE_8#PROKKA_00222
+VEVDISLFSNQNQFVILRVGEQAYALPAAQVREMQVLPEVTEVPRAPAHLRGIISPRGEV
+LPLFDLRRRLGMRSLAEEADELLKILEAREQEHKQWLEELESCIREEREFTLPTDPEKCA
+FGQWYQNFTTEDLALASVLERLAAPHRRVHEVAGAALEALEKEGQAAAQEVIDRARRIIL
+PKLLELFAELKRLIRETHQEIAVILESGRHTLALAVDNVDSVELLQPKDLQNLERFGPVD
+GSQDLLESVGRRANGETVYILKTAEFFQAATDLTF*
+
+>7FR_NODE_8#PROKKA_00223
+MAHGQEPAYEMKSEPAGNGELRVDLSGRLDMNALEGAVDQFGRLLKEQRPRRVELAVGGI
+DYLDSGGALALTLMEEAARKAGTKFQLVQAGPEVRGMLALVDMDKIRRRPLRPAERGLGF
+VEQVGQASLEVWRDFVELVTFLGDFLIALGRSLRRPRLVRWQETFFYMEQVGVNGLPIVG
+LISFLLGLIIAFMSSLQLKTFGADAYVAALVSVAMVRELGPIMTAILVAGRSGSAFAAEI
+GTMRVNEEVDALEVMGFDPTDFLAMPKVLAALAVVPMLTIYSCVAGILGGMVVGIWGLGL
+TPYTYLHHTIDSLSAYGIVTALIKSVAFALIIAGIGCQRGFMVRGGAQAVGSATTSAVVT
+AMFLIIVADSAFAILFYYVF*
+
+>7FR_NODE_8#PROKKA_00224
+MSAEDPIIEVRGLKAQFGEQVILRGVSFAVARGEVVVVAGGSGCGKSTLLKHMLGLYQPA
+AGSVLIDGVDIAQADAAQLEWVRRRIGVLFQSGALLGSLTLLENVMLPLVGFTPLSRRGA
+ELVARLKLSLVGLSGYENHLPSELSGGMQKRAGLARAMALDPQVLFFDEPSAGLDPVTSA
+ELDLLIKRINRNLGTTMVIVSHELASIFEIAHRVILLDKQAKGIIAMGPPQELSGVPRLF
+PGGIL*
+
+>8FR_NODE_2#PROKKA_00225
+MCNLLIKFGAFNDRFGKDFDRISTGHYATRYNTDEGVFLSTAADRVKDQTYFLGQITPEQ
+LAKTMFPIGHLQKKEVRKIASDMKLPSAHRPDSQGICFLGKINYTDFIKKYAGEKPGEII
+ELETGKVLGTHKGFWFHTIGQRRGLRLGGGPWFVVKKDIEKNIVYVSNGYDPIAQYDDKI
+WLEDLHFLNKVHDYSKLNEIKFKIRHQPEFNSGKLVRDEKGIRIVSENKISGIAPGQFAV
+VYDEEERTCIASSVIAENPEIAV*
+
+>8FR_NODE_2#PROKKA_00226
+MNPLLLFILIVSGGLYLAGHYLHKPILKYIFKPFTTFIILFFAFMQLPDVSVQYKDYILI
+GLLISLIGDIFLLWPEKRFIHGLGAFLLAHVLFILAMVSDFGPYYNWQYLIPIALYMVIF
+LWIILPKSGKFVIPIIVYALVLMVFFWQAAGRAIYLAESSSMQAMFGATLFVASDSILAY
+NKFVKNYKWAEFFIIITYWAALYFIALSV*
+
+>8FR_NODE_2#PROKKA_00227
+MDWIIVIILAILLVAFIILFLLIQKGFRNPVSEHTIPEDLPFDVQEVEYPTKNGKTIYGW
+WIPADPKAATVVFVHGWGRNAQRMMPYLRKFCCGKFNLLAFDARGHGNSDHDGFSNMLQF
+SEDIIASMNFIEQEHKAENNMFYLIGLSIGGAASIYAAGHDPRVKKVLTVGAFAHPASVI
+TKQIKDRHIPYFPMIWFLYRYMKYVKNLDVDAIAPEKHIAKAQAHFLLVHGEIDQTVPVE
+QGKRLKKAAGDKADLWLMPERGHSDCHLEHGFWEKLMEFFEAPKTKVQKS*
+
+>8FR_NODE_2#PROKKA_00228
+MKKFHLLLLSLLSGLLLAAAWPLHGFTPLIFIALVPLFFVQQQMGDTGKRGMLLYAWLTF
+LVWNGLTTWWIWNATPVGAIVAIVLDSLFLAIVFQVFHLSKKWLFNNKQGFFILIFYWIA
+WEHFNANWDLSWPWLTLGNVFASKHLWIQWYEYTGVLGGSLWILSVNILIYNIIKSFLEK
+RKQRALYTTILTVLFIAVPIIISLNIYHHYKETKNPVNVVVVQPNTDPYTEEFNLPPSAL
+IKRNLKLAEQKVTDSTDYVVFPESTIQEQIWEGSLNRSQSIKTLRNYVMEHPNLSMVIGA
+STFRWLKPGEHRTNAARFYKKGLYYYAYNTAFFIDHSPYIQVHHKSKLVPGVEKMPSWPI
+LKPLEHLALNLGGTVGTLKEDDHVSLFTNDSSGTKIAPMICYESVYGDYVRQYVAHGAEL
+IFVITNDGWWGNTPGYRQHFSFAILRSIETRRDVAQSSTTGYSGFVNQRGDVLQRTKYDE
+KAALSQTLNLNDKLTYFMKKGDYLAHLAGFFSILILLAAIVQGFLKKRNLPH*
+
+>8FR_NODE_2#PROKKA_00229
+MKTFLDLVNQRQSDRKYIDKPVEKEKLMRCLEAARLAPSASNSQPWTFVVVNQPELCQDV
+GKAAMGPLYSFNKFASQAPVILAIIMEKPKVITEVGGRIKKKEYPLIDVGITAEHFCLQA
+AEEGLGSCMLGWFDEKKVKELLHVPEEKSIPLLITVGYTPENYKHRKKIRKPIDSAVKFN
+TYG*
+
+>8FR_NODE_2#PROKKA_00230
+MAKQKTQEKIWYAIYVKSRAEKKVAIELEAEGIDFYLPLEKRLKQWSDRKKWVEEPLFRS
+YIFVHISHKDYYRALVQNTVKYVTFEGKAVPVPPEQIEAVKVYLEEKEPIQPNDEDWETG
+KEVEVISGKLTGLKGVLMEVKGRSRVKVEIEVVSSSIILHIPKSKLRLLE*
+
+>8FR_NODE_2#PROKKA_00231
+MGVNLLDIILAVPLIFFGYHGYRKGLIIEVTSLAAFILGLYFAFYFSNFTAGILKEYFTI
+QTKYMAAIAFVVTFIVVLLIVLAVGKIVEKFIDILLLGFLNKLAGGLFGVLKGALFLSII
+IFVINYFDASHSIIKQKAKDNSVLYKPVESIAPALYSWLHLKNFDFHLPSEESVIKTITH
+RANPD*
+
+>8FR_NODE_2#PROKKA_00232
+MGLSYRINFKLGANAMVISDPSMPVPASLQFRQLKSDEYVMLDIPTDSLEVAYWGTKKPV
+PAQYVLTEAQTAKVESAITSYNAEIKSLAKKYNLAFVDFNSIMKSIEHGGLTVDGIHFTT
+AFITGNLFSLDGVHLTPQGNAVVANYFIQAINKQYGSHIPSVMVSDYPSVVFP*
+
+>8FR_NODE_2#PROKKA_00233
+MSGKLQAEFRSDLKWQPAILRKILILPSKQVLIILSLMAVVVVQARPPLF*
+
+>8FR_NODE_2#PROKKA_00234
+MKIIKLAMFSKTQTMLQHKDINKLSELKNGFTQSWVEPDFIFRSLKCFSFSSLNKGLSPL
+KAKGYSFEWVMSLLISLPFMGISSVNRLAGVVEAKKDVFYRLKNNSSISWRYIQWLFACK
+FNTITSESTGNNIQPRCLIFDDTVIEKTGRFIEKVSRVWDHVQNRGVLGFKLLVMGYWDG
+TSFLPLDFSIHREVGKNKEYPYGLRKKDYRKQFKKKRSSQTHGYDRSKEAGQSKIDNMIK
+MFKRALSHGFSIDYVLVDSWFTCEAIIQAVTQVKNQTVHLIGMYKIARTLFEYQGTKQTY
+SQIRNRLGRPTRCRKLRLYYLQATVGFKGHQLQLFFTRQGKNGKWKVLLTTDCSIGFIRL
+VEIYQTRWTIEVFFKESKQLLGLGHCQSNDFDAHIADLTITMIQHMLLTLRYRYDTYESK
+GALFENVKETIAIRKLNERLWGLFVELLQILTDLFEIVDAMELLEHIITNGQALERLKLL
+FDLVPENNEAA*
+
+>8FR_NODE_2#PROKKA_00235
+MSQAEAPVIIKPNFKITNFLSKEPRSSLIHEIFSGLTAKQKYISSRFFYDRKGSALFEEI
+TKLPEYYPTRTEKSILSAHAKEILGNPESLVIIELGSGDCSKISILFDNFPEQKMSNVKY
+IPVDVSESAIIKSAEILSSRYEGLKIHGLLADFLKHLDLLPGATPRLICFFGSTLGNMTR
+NQATDFLWNLKNIMNPGDRLLLGLDRVKGPEILYKAYNDKQGITAQFNKNILNVVNDVSG
+TNFKTSDFGHLAFYNQNENRVEMHLKALYDMRITSKHFRDDIFIVKGESIHTENSHKFLP
+EQIEQLALSSGLKFQASFTDVNKYFSLNLFEYPKLK*
+
+>8FR_NODE_2#PROKKA_00236
+MPQFFKQLSTRELTERLNNKDVQLIDIRPVDAYNGWASRGESRGGHIRGAKSLPFAWTKY
+VDWIEMVHRKKILPENEIVIYGYPDEGFRLVANRFKKSGFEKVSIYLNFLNEWVPDTTLP
+MEKLFRFQNLVPASWVNELISGGKPQHFENDKYVIVHAHYRNRDAYLSGHIPGAIDMDTL
+AVEDPETWNRRSPEELKQTFEQHGITVDTTVIVYGKFMFPDNSDEFPGSAAGDIGAIRIA
+LIMMYAGVKDVRVLNGGFQSWLDAGYEVSYADEPKKPVADFGATIPAHPELAVDTPEAKE
+MLASSRAELVCVRSWPEYIGEVSGYNYIEPKGRIPGAIFADCGSDAYHMENYRNFDHTTR
+EYHEIEDIWKSNGITPDKHLAFYCGTGWRGSEAWFNAWLMGWPKVSVYDGGWFEWSADPA
+NPVETGIPENYPNRN*
+
+>8FR_NODE_2#PROKKA_00237
+MKAIWNNTILAESNDIVKIEGNAYFPINSVKKEYLKTSETHTVCPWKGTASYYSLEVNGK
+ANPDAVWYYPEPSDLAKGIKGRVAFWKGVQVVKD*
+
+>8FR_NODE_2#PROKKA_00238
+MIKYYLLLAFEKKTLIRAIRVAILVGIILNLINNPDFIFHFSTNYLSLGRVLLTFIVPFL
+VSTYSSVLSNSALRTGSVSHIDAILKCKSCNKTHIHVPIGHEVEECPICKKETRWRPVRI
+FSGSGNRDELLKSLALFARYNPTPLFRINSDSIINEANQAAKDIFGSDELTGKNLAGIIP
+EIKDINLNQLIHDGAIKKTIIHKEGRDYNITLKGIPELNSVHGYLNEVTNFVEPEQKG*
+
+>8FR_NODE_2#PROKKA_00239
+MKENLEWHKVLEKKEDLPENRIITVNAGSKQIALSHFEGKICALDNHCPHQGGPLGEGSI
+ENGILRCPWHGWDYHPCTGKAPGFDDGVATYRVEERGNGIFVGIPPKKPHKTTLSDIMVE
+TMVHWGVDTVFGMVGHSNLGLADAFRRQEEKGKLKYIAIRHEGAGAFAASAYGKLKGKPA
+ACFSIAGPGATNMFTGLWDAKVDRSPILALTGQVATQVVGTGNFQEVDLVRAFQTVAAFN
+HRVQKDSKHAELMSLAIKHALLKRDVSHLTFPDEIQEILEGKEESQTPEGRMGELQISPA
+AGSMDKAVDFITKSKRPVVIVGHGARFVMEQIISFAEHLNAPVLTTFKGKGLIPDDHPLA
+AGVLGRSGTPVASWFMNESDLLIVLGASFSNHTGITPKKPIIQVDFDPLALSKFHKIDVP
+VWGELSTTVNILMKRLPVKPNTVDQRTELAQRWKIWRTEKQKRLLEDRGKGISSIAVFDN
+LSKLIHPEAVVCVDVGNNAYSLGRYFESKNQSFLMSGYLGSIGFAFPAALGAWAATRGKR
+QIVAVAGDGGFAQYMAELATSVKYNMNIKLVLLNNSELGKITKEQRSGGFKKFATDMHNP
+DFAEYARGCGALGIKVSKRKDLKTKMKEFLDYKGTALLEIVTDVLLV*
+
+>8FR_NODE_2#PROKKA_00240
+MQEYIKTDRQIHWLSQAIAKVNRDYVPAKKDDSHTNLFLDAAGKRLFGRWINTPKGKFIL
+ALNLKTLSFEWLDNPLSVKTSISVFDKEGSSIEKEIREFPVSMGMSSKDISKPLHFEIPD
+YGFSIIKSNRISSFGIKQWIYYRGLANFACLSVLGYLQSESEIRIWPHHFDTGVYAQVTD
+SLGFGFGWAMADSMIGEPYYYLSGYKNSSIIIYNNLSKLNFGRWVTGEQWNGTVLPLHVL
+ADNSTAKALEIINTYIKESIDWFLNL*
+
+>8FR_NODE_2#PROKKA_00241
+MNQEKKKLVLLAFVLLLAGISPNIFPAAQSGIASMSSLAVVLLIPSVVLIFILAILSQAL
+GYNDLRKQILNGILAGLAGTVGLEIVREIGFHLGGMPGDMPKLLGVLLLNRFASGPDFWS
+NVAGWSYHFWNGAAFGIIFSLIIGRGKIWMGIVYALLIGTGFMVSPATTSLGIGVFGLHF
+KDGYQFLTTVYLAHIAFGSIVGLVVYKKNKDAPNIFKRLKLAFS*
+
+>8FR_NODE_2#PROKKA_00242
+MMVMSQLDQGKILSMTGLSVKSHSFFIGNPNVGNKAFSADPAAGLVIPVRVNVYEENGKT
+YVSYFKPSDLFGSFKNAKVKMIGQMLDKKLGMMLKMVTR*
+
+>8FR_NODE_2#PROKKA_00243
+MSVLMHNNQDGAVRFVFNNLSNKQTKQKSAETLKKLDLYKTMSKFKSTGVVYFFDAKNKS
+LISHISLARSNKQLAEALTNSEKMAK*
+
+>8FR_NODE_2#PROKKA_00244
+MMKKLMNILFLSCLKATELIEKKLYFKLSLKEKVQLKAHKMMCDACTNYEKQSIFLDKGI
+SHLNQSKIKKEDLEEIKKSIQQKLNELK*
+
+>8FR_NODE_2#PROKKA_00245
+MPQTKTTDLTYLVETYTEEMVSWAMYKVSDAELARDLVQDTFLAAAEKMDAFKGESSPKT
+WLFSILNHKIIDVYRNKVKQPVSFDSQVFSTYFNERGDWKKEKEPKDWHQEEKQLLDDSA
+FQQVLQKCLESLPEKWSTCVKMKYLSEKKGEIICQELGLNPTNFWQIIHRAKIKLRDCVD
+QNWFRS*
+
+>8FR_NODE_2#PROKKA_00246
+MKTIDNYDFKGKKVIVRVDFNVPLNDQFEITDDTRIRATIPTIQKLRESGGAVILMAHLG
+RPKSGPEDKFSLRHVVKNLSEKLQTEVQFANDCIGDEAREKAAALKGGDVLLLENLRFYK
+EETAGDEAFAKKLADLADVYVNDAFGTAHRAHASTTIIAKFFPNDKMFGYLMENEVKSLD
+KVLHHAERPFTAILGGAKVSGKIEIINHLLDKVDNLLIGGGMMFTFIKGDGGKVGSSLVE
+DDLIETANAAREKADKLGVSLFIPKDAVTADKFANDANQKCRPSGEIPDGWMGLDIGVET
+SETFRQVIENSATILWNGPMGVFEMDAFAEGTVDVAQAIVRATEKGAFSLVGGGDSVAAI
+NKYNLQDKVSYVSTGGGAMLEYMEGKTLPGVAAIKDE*
+
+>8FR_NODE_2#PROKKA_00247
+MSQLANDHKAINLSQGFPDFPISEELIDLVHYYMRKGYNQYAPMQGVLPLRKAISTMFQK
+NYGIHYDPVSEINVTAGATQALFSAISAFIKDGDEAIIFEPAYDSYAPAVKINGGMVKYA
+HLEFPDFNINWEDFPRLITNRTKLIIINTPQNPTGSVLSEDDLQRLERITSGTDIIVLSD
+EVYEHLIFDGITHQSVCRFPELAKRTLVIGSFGKTFHATGWKTGFVLAPERLMKEFRKVH
+QFTVFASNTPIQHAIADFIGNEDNYKNLGKFYQQKRDMFVKSLNGSKFNVLPCYGTYFQL
+LDYSNISDKNEMDFARWLVEKHNIAAIPIAPFYHKKDDHKVLRFCFAKKDETLVEAGEIL
+SKI*
+
+>8FR_NODE_2#PROKKA_00248
+MNDLKILYIQSRLAWEDAETNRKHFEEIIQKEAQHHDLIVLPETFTTGFPVDPVPFAETE
+DGESVLWMREMAAQTCAVVTGSMLLKNDGVYTNSLIWMRPDGTYERYNKRHVFRMGGEHE
+KIHPGDKILLVELKGWKIRPMVCYDLRFPVWTKNHYEKDAFEYDLALFVANWPAVRAYPW
+DQLLIARAIENEAYVLGVNRIGKDGLGNDYNGHSKVVDAKGNVISEAPENEEAAISVKLS
+YEALQKFRAKFNVGQDWDSFTIQK*
+
+>8FR_NODE_2#PROKKA_00249
+MKRLGKHFAVLILAAGYSGRMGMPKAFLPYDANRTFLEKIVSEYLEFGCNLVGVVLNEEG
+MKLYEKMQLEHKNNITAILNPAPEKERFFSLQTGLKRLKSEGAVFLHNVDNPFLTQDILQ
+ALASAFKTQAYVVPTYHEEGGHPILLSQEIVKALIETSDYEQNLRVFMESYDQIQVPVSD
+PNVLANINSPQEYERLFGRSF*
+
+>8FR_NODE_2#PROKKA_00250
+MDKEKKQKRYQRLYKQIQDLIVKSSNNPLSNMATINAVLYHKMETFFWCGFYLYQDGKLQ
+VGPYQGSLACINLAEGTGVCQAALTQQKTLTVPDVEAFPGHIACDSRSKSEIVIPVRNRE
+NELVGVLDVDSKEHNSFDEVDEAELEKIVRLVYFPEG*
+
+>8FR_NODE_2#PROKKA_00251
+VLIKKAMNRVERGKYGEVHSVLIYKDGKLVLDEYFKGHDYKWEAKKHYGPMVVWDADRAH
+SAHSVSKSITSLCVGIAVDKGLIKDIHQSIFDYLPEKYQYLNVGDKKYITVENLLTCSSG
+LLWQEWSAPLSSKRNDQVGIYFHKKGPLDFVLNRPFVAVPGQRFNYSGGGVEVLGEIVKN
+VSGMAFDEFSQKYLFEPMGIKTASWALKYPTGEVHAAGSLKIRPRDMIKIGAMMLNNGIW
+NGKRIVSEDWVEKSRKPWGNNRGIDLPGEDLRDMGYAYNWWTKNEKINGKAVHWFSANGW
+GGQQIIVLPEINTVVVLTGANYNRKVKQYALLADYIFPAIK*
+
+>8FR_NODE_2#PROKKA_00252
+MQQMEILERYLNENKTINEFKKVLWIYDFWGKLTEGKAAKKVLEFAGIKNGISVLDVACG
+TGEMLEKVVKLNPDGQNSGIDLSPDMIAKARKKLSKTGHLNFNLKQGSALDLPFPDNSQD
+LLINSYMVDLLPVDCFDKVATEFFRVLKPGGKVVMSTFSFGTKKVHRFWFWVARKFPALL
+TGCRPVSFKHFLIKAGFEIVKDVEISQNTFPSQVLMALKKS*
+
+>8FR_NODE_2#PROKKA_00253
+MELNVQIDHVHLVVSVPPKVSVSRLMGILKGKLAIKLFKSYPSLKEKPYWGNHFWARGYF
+VSTVGIDEDVIKRYVKYQEEEEKKIETQQQRFDF*
+
+>8FR_NODE_2#PROKKA_00254
+MRYDYFASQAKKEGLEQISALFTETSLNEKEHAKRFFKFLEGGPTEIVAAYPAGIIGTTL
+ENLRAAAEGEHEEWTELYPEFARVAEEEGFKEVAAAFKMIATVEKAHEARYSKLYKNLEA
+GKVFQRDGVVVWKCRNCGYLHEGKKAPKKCPACLHPQSFFEVETFGY*
+
+>8FR_NODE_2#PROKKA_00255
+MNIEAFYSLSYGLYIIGTASKGKKNGYVANTAFQVTASPEQIAISCNKDNLSEQMIDESG
+YFSLSVLEKDASKEIINRFGYKSGKTLDKFEGTKYFETNNGIPVVTEECVAWFECKVEQK
+VDVGTHIIFIGRVLNGEYLDENKESLTYTYYRQVRHGLSPKNSPTYVDKSLLPEKEKKEE
+KAEETPAEKPKGKSMQKWECIVCGHIYDPAVGDPEQNIPPGTAFEDLPDDWVCPDCGAEK
+EDFEPIG*
+
+>8FR_NODE_2#PROKKA_00256
+MFSKIFINRPITAIVISLFIIIVGIISIFKLPVAQLPKVTPPVVSVSGHYTGANASDVEK
+AVATPVENSVNGATGMLYMNSTSANSGSFNLNVTFKIGTDVNVDAMEVQNRVNLATPILP
+AEIRQTGLSVKKASTSMLEIVGLYSPHGTHDEKFLSNYAALYIQNALSRVDGVGDVHVFG
+NSFAMRVWLNPQKMANLHLTTQDVINAVREQNAMIPAGSVGASPAPKGQTFQVTVQVKGR
+LVTAKEFGNIVVGTNPATGSVIRLKDIARVKLGSSSYAGTPRLNGKVGCGLAVYQTPGGN
+ALETADLVKAKMEQLSKNFPTDVAWTTMVDNTRFVQSSIDEVVKTLFEVLLLVIIVVFFF
+LQTWRPTLITMLAVPVSIIGTFAIFTLIGFTINTLTLFAMVLAIGIVVDDAIVVVEAVQH
+NIDRYGLTAKEAAIRAMSEVGGPVVAIALILTAVFIPVTFMPGITGMLYKQFAFTIAISV
+LLSAFVALTLTPALCSIMMRPNPVNENSKGLNRMFYKFNIWFDKTVENYGATVRKTIKHA
+PLMFILLGAIYIGTGLFSKYTSTSFLPNEDQGMVMAIAQLPPDASTQRTVKVLNQFGKIL
+NHNKNVKRYFLAPGFSVLQGAQMSNFGTAFIRLTNWSKRKGKNSSIQAVIGQLMGASSQI
+KGAKFMIIAPPPIRGLGRTNGFSFVLKQSTGSIQDLEKVQNKFLAALNKRPEIQMAYSTA
+TFNYPDIRVTIDRVKAKKMGVSLSALDNTIQTFLGGYYINDFTLFNRTFRVYAQADSSYR
+ANINDLSEYYVRNNQGNMVPVSALVNITRGTSAPVITHYNMDRNVNISGNAAPGYSSGDV
+IKVLRQVAQQVLPEGYSYEFSGTTLQEIEGGKTSTFIFILAIVFVFLFLSALYESFAVPF
+AVLLAVPIGIFGAYLSLHIGGLSSSIYAQIGIITLIGLAAKNAILIVEYCKMKYESGVPL
+VQAAVEAAKLRIRPILMTSLAFDLGVIPLMIATGAGANARINIGYTVFGGMLTATLLAIF
+FIPLFYVTIIKIRDRKKKPELVKTED*
+
+>8FR_NODE_2#PROKKA_00257
+MKSEVNGRVEDILFKEGGSVKKGQPLYTINKSLYQAAYDQAAAQLNIAETNWATDTTDAR
+RYKNLWAHNAVDKIQLDHAIAKVNVAKASVIAAKANLESAKTNLDHATVRAPFSGSTDVS
+KVRLGDVVVAYQTPLVTIVDNSNMNADFFITENDYLQLGSSDKSIKEKLSHFRLVLPNGK
+LYPYKGKLYAVDNRVDPTTGTLMVRLKFPNPEDLLKSGMNCVVRSTQNSAGKVVVIPQQA
+VTQLLNEFFVYTVNSKGIVSQQKVELGAEYGNMQVIKSGLKPGTKVIVEGIESVRPGAKV
+KTVPMKTGGMAKQSKPE*
+
+>8FR_NODE_2#PROKKA_00258
+MEFKFEKLIIWQKAMEFGEEINSIAHKFPKDEVYNLSSQIRRAVDSIALNISEGSIGQSN
+LEFKKFMSYAIRSLAEVVSCLHKAKRRNYITEDEFKKQYEFAYNLMNMMVAFREKIK*
+
+>8FR_NODE_2#PROKKA_00259
+MLLKKLNQNKFFSAFLAVSFLLSGFSVSLKAQGQKAVYQFNLNDCIHYALQNQASVKNKI
+LSEKISRENVKEAYSKLMPQVSAGAKYQYTIKRQVSFIQGNPVLFGVPHQLQGYLNVDQT
+LFDPSVLGSAKAAHLSENLSKENTQLSKIDVAANVKKAFYGVLVFREQLNLLNANIKRDT
+KSLADTKNQYKNGLAQKVDVDRIQVLVNNDVTARANASRNLNTLIQTLKYHMGMPIKDSL
+VIKGTISDAMLTEILPENNPMFYKNRVEFQQAQTTLAATKLLKSNVIRSYFPTLSAFYTL
+EAPYNSNTFPGLFKDKLYPTSFVGLQLSIPIFSGFNKHYQYQAAKMNIQISKNNISDLEN
+NIKLEYGNYFRQYKSDIANLKTQKENTKLAKLNYDNLKYQYDNGVQPLIEVLNAETTLLQ
+AQDNYINALYQALVDKVDLDKSLGKLKY*
+
+>8FR_NODE_2#PROKKA_00260
+VVLLLSLAIIIAFRKFSSNIHFLENIGGVLGTVVSASFLTLIGIINFFILKNLYRMFKLY
+KKGEGAEKRIEEITENLLNKRGLLNRFFRFAYRSIDKSFKMYPLGFLFGLGFDTATEVAI
+LGISATVAKDSQLPIWGILAFPLLFAAGMSLMDSLDGLIMMRIYDWAMVDAVRKVFFNMV
+ITGTSVFVALAIGTIEWLQVVSIEAKESLSFFSFLNHLDFSVLGVGVVIIMLISWLSAFV
+YYRKVLS*
+
+>8FR_NODE_2#PROKKA_00261
+MDAGEEKASPKKTILIAEDDETSFFFLKFVLAKENVNILYAQSGQEAVDICEAHPEIDLI
+LMDIKMAGMSGIEATQLIKKRNPRVPVIAQTAFALSSDKENILKAGCDDYITKPIRKEEL
+LEKVNFFLYSKKES*
+
+>8FR_NODE_2#PROKKA_00262
+MLAISIVILLILSFQVMPVALGIDSHKMNVFHVASSIFLLILGQVLLFLLGILLGDKFMY
+LMSGFKRFVLFIGFFIIATRMIMEALEIRKGKRTYLLDKAKQFILPSIAQAINTFLAGIL
+FQLLIFNLSKDLIYLGIFALAFSVPFIFIKNEKQSMLAVSLLYMVGGGILSILSFYFLFI
+*
+
+>8FR_NODE_2#PROKKA_00263
+MKKHLNINEPTRIRITKEFKFEMAHALKGYDGLCRNIHGHSYELMVTVSGFPIEEENHPK
+LGMVMDFGDLKKIVKEEIVGQFDHALVLSKKMPVPLVDELKNQFERIILTDYNPTSEMML
+IDFAARLKARLPENITLKHMLLRETVTSYAEWFAEDQD*
+
+>8FR_NODE_2#PROKKA_00264
+MYKKLLLLSLTFFMFTSFTNIASAQSNNIEIARLKQIHKLLDYRFVGGFYGFEKLFFQTV
+SYPDEARQNCTLGIMIASFTVNCDGDLVGIRIRNSLGKPLDNQVSKFLKATKGHWNPCQD
+KKFTHFEIPIQFTLKGTETDSTAAALVYVGKSAGYSCYPDSYYSVPRLFPGGIL*
+
+>8FR_NODE_2#PROKKA_00265
+MEAITNGMMNLNRQRHQHLVALRIIFAHGENGGEEVVHIGHVAIKTGDTFPGTGRVDLLC
+LTHCLTSTD*
+
+>9FR_NODE_13#PROKKA_00266
+MGKIVGIRFKKGGKVYDFDAGHFVLSVGDMVIVETEQGQALGEVVRPPVSHVLPELAPKN
+RCCEGCEDSGDEPAQLKQVYRLATEEDLRQLVENAKLEKEAFRYCQERIAARRMDMNLVK
+VECFFDRSKLMFYFTAEGRQDFRELVRDLVSRFRTRIEMRQIGVRHEAKLLGGLGSCGRE
+LCCATFLRDFEPVSVKMAKEQNLSLNPTKISGLCGRLMCCLTYEFETYKGLKQGMPKLGK
+RVSLNSGLEGKVIRQNVLKRQLTVILSDGREFTGTPEELEQLEPLAKPQAPPKPRGGQRQ
+QRNQQQGKGQQQTNSGGKSRSRNRRRKKKGS*
+
+>9FR_NODE_13#PROKKA_00267
+MSETFYLTTPIYYVNAEPHLGHAYTTIVADVACRYQRLAGRQVRMQTGTDEHGDKIAQAA
+AKEGIQPKEFTDRISGKFRSLWPQLNIQFDNFIRTTDPQHMQVVQAILSKVHEAGDIYFA
+KYGGHYCVGCERFLTEHEMIDGKCPDHGTEPVYQEEENYFFRMSDYTQPLKEYIRANPDF
+IRPERYKNEVLAILDQGLEDLCISRPKTRLTWGIELPFDQNFVTYVWFDALINYLSGLDW
+PDGELLERFWTGPKADPQHLIAKDILKPHGIYWPTMLMALAKAEGRPLDHYLYRHLNVHG
+YWQVGEGKMSKSRGNVVKPLDLAGIYGVDPFRYFLLREMTFGLDASFSEDLLVERYNADL
+ANDLGNLFSRVLNMLSRYRDGLLPELHPQELTEADREMKGALAASLGPGAEHDFQAQVRE
+FRFHTALADLWSQVRRANKYIVAREPWVMAKDPDRAAELDNVLYILVQLLASVTHLAWPV
+MPATAEKMAAMLGLELVVPVDWQRLFALELMTPGAKAEKPQALFPRVQTDKVKAKAARKE
+AKQAQQQPAAKGGGKQKAKPQDKAGLITIDEFAKVELRLGRVLEAGAIKGADKLLKLKVD
+LGEPEPRQIVAGIARHYRPEELVGRQVVVVANLKPAKLRGEISQGMVLACVAEGRVRLVA
+PEEELPPGSVVR*
+
+>9FR_NODE_13#PROKKA_00268
+MRARLFKWAGVFFLSLAMAGPAWAASRATPHRRPVLKLHFADVSYDYELKRAMSYAVSGG
+ADINECLTAARAITAGDGESWYRGWHRMARRLDQMADQALKAGHRQTARQFWLRASNYYR
+AAEFFLHGNPKDPRILSAWGASRRCFRQAARLMDHPVEVIAIPYEGHKLPGYLVKPDASL
+KPRKTLLLQTGFDGTGEELYMEVAWYAIQRGYNVLIFEGPGQGGALREQHLYFRPDWEKV
+VTPVVDYALTRPEVDPKRLALMGLSMGGYLTPRAAAFEHRLAALVADPGDFDMMVGHRPT
+PAEWAGMKKYPKQANQALRAKMKHDTGFRWLVNNGMFTTGRKTPLAFLEFFSRFELTPKI
+AAQIKCPTLVVVGAGDHFASPKWQRLLYDNLTAPKTLLRFGPDNPARQHCQVGGLLWGNA
+KIFDWLDQVLR*
+
+>9FR_NODE_13#PROKKA_00269
+MSETPRRPRDSRYMWRGIRPSEEELKTILEDHAQWLERLRSWEYSWREFIEEIPPPHDLS
+GADLLEADLSDADLTWAKLSNAILFEADLSNADLREADLSNAKLWWADLSDADLTWAKLS
+NAKLLAADLSNAELWWADLSNAKLIKADLSNADLTGADLSNCDVTGVRYHGPWLGIPFIQ
+IRKPNKLTCRGIRADTCYGSPRFRRDVMDQDFLEEMRETTGGRWLYRLWWLTSNCGRSFI
+RWAFFSLSLAVAFACVFCSSLGPECFDLHRAEGSRWVAEVAGRYLEVDPAYLGTTAASRG
+LPGDFWTMLYYSLVTFTTLGFGDVVPLTPWAAFWVTIEVVTGYIMLGGLVSILASKMARR
+AG*
+
+>9FR_NODE_13#PROKKA_00270
+MWQEHIAGRKIGLETGPRPFDPHKPCLLMVHGSGGRGETFRPQLSGLAPYLNPAAIDLPG
+HGNTPGPGRDQVAHYADWLAEFIRRGPLRPALLGHSLGGAIVMQLALDHPDLAPALVLVG
+TGSRLRVLPAILDGLLSDFDATLDLVLKYAYAPGADPRWVQAGREIMSQPGPRVVHDDFA
+ACDRYDITDRLGEITAPTLLIYGDQDQLTPPKYGRFLAERLPDARLEIVAGAGHMVNLER
+HAEVNRLIPPFISAFSPPASS*
+
+>9FR_NODE_13#PROKKA_00272
+VLFTQIIAFVLVMVVYQAYDPAPPDYGWGWGLLLFITGPLLEWLLASVIARSGLRRLARP
+AADPARSLQRSEILLHLSALTVFFLFMVSYDLKAGLIATPLLAASETLSGLAALFYYALL
+LIPVWGHCHRLERAAGRALALDRRRYILEQARFVAPVAFPWFLVSALRDLLTLAWPGLTA
+WLETPAGDLAFLGFFLLVISWLFPPLVRSWWGCPPLPPGRAREICQMVLKVARVRVGGIL
+SWDVLQGRLVTAGILGLFPRFRYLLLTPALLEALSPTELAGVVAHEAGHVRLKHIPAYLM
+FFMAFFLLAYALAEPLDILLRLALLTLAQSDWGAGLLNSPDAGSTLSITFALPLLALMIV
+YLRFVMGFFMRHFERQADLFALNLMGEAAPLVGALEKLALMSGQTRDLPSWHHFSVAQRV
+SHLLTAQANPPAWLHRQGRLIKKALAVYLAGMVLVLGLGWGMAGLDWSRQVNQELALELV
+RHQLAQHPDDPRLRFQAGMLCYQLGREDRALSHFRRAFLAAPDNPELLNAMAWIFATSQD
+PRRRRPQVALVLARRAVSLSPLPHIWDTLAEAYFAAGQPVKALAAARAALEAGPKARLDY
+YRAQLERFKRAVEDLKKKGPAGRRPRPAAPAPGGRQG*
+
+>9FR_NODE_13#PROKKA_00273
+VEPTVPSPLLDRRQRGDAFLRRYWKLAAPLLILFMLALFVLPWVWFSFVEALCLQVGGAG
+LLYILGRLFTTAFNPAYHQAPEPQDGDAGRRDPSSSDPPPRA*
+
+>9FR_NODE_13#PROKKA_00274
+LPLAFHSSSHGVVAFGFFHIETPMLLLEELFFFAPEFCDALVRLAQAPPERDWQGSWTGF
+EIPDPASRGDLHGAIAGRRLEGFIGALYARWPFPRDPHQFRQRTRGAAPREVVEQEAESF
+GRRREVVLEARAGGGEFAIGQYRFHRTGFLALVDYVWRGGMPGWEGGRRPEWLLEAARRI
+QESDSPWLAGLDWDPARLGFTI*
+
+>unf122_NODE_11#PROKKA_00275
+MISVYDDQSVLFCSWSVVLSGVILRIRILNGRGGRLPITTEARYCEVVLPLMVMSFSVTQ
+PPLRCI*
+
+>unf122_NODE_11#PROKKA_00276
+VKTGAEAIRALATQLPAFRQKLSDGWYQVRIAGRDVSTSGLTAQLHETLPDGAVIHIVPR
+VAGAKSGGVFQIVLGAAAIAGSFFTAGATLAAWGAAIGAGGMTGILFSLGASMVLGGVAQ
+MLAPKARTPRIQTTDNGKQNTYFSSLDNMVAQGNVLPVLYGEMRVGSRVVSQEISTADEG
+DGGQVVVIGR*
+
+>unf122_NODE_11#PROKKA_00277
+VVSTPEGERYFPCVNISGEPEAYFRMSPEDWLQAEMQGEIVALVHSHPGGLPWLSEADRR
+LQVQSDLPWWLVCRGTIHKFRCVPHLTGRRFEHGVTDCYTLFRDAYHLAGIEMPDFHRED
+DWWRNGQNLYLDNLEATGLYQVPLSAAQPGDVLLCCFGSSVPNHAAIYCGDGELLHHIPE
+QLSKRERYTDKWQRRTHSLWRHRAWRASAFTGIYNDLVAASTFV*
+
+>unf122_NODE_11#PROKKA_00278
+MQDIRQETLNECTRAEQSASVVLWEIDLTEVGGERYFFCNEQNEKGEPVTWQGRQYQPYP
+IQGSGFELNGKGTSTRPTLTVSNLYGMVTGMAEDMQSLVGGTVVRRKVYARFLDAVNFVN
+GNSYADPEQEVISRWRIEQCSELSAVSASFVLSTPTETDGAVFPGRIMLANTCTWTYRGD
+ECGYSGPAVADEYDQPTSDITKDKCSKCLSGCKFRNNVGNFGGFLSINKLSQ*
+
+>unf122_NODE_11#PROKKA_00279
+MKTFRWKVKPGMDVASVPSVRKVRFGDGYSQRAPAGLNANLKTYSVTLSVPREEATVLES
+FLEEHGGWKSFLWTPPYEWRQIKVTCAKWSSRVSMLRVEFSAEFEQVVN*
+
+>unf122_NODE_11#PROKKA_00280
+MAEPVGDLVVDLSLDAARFDEQMARVRRHFSGTESDAKKTAAVVEQSLSRQALAAQKAGI
+SVGQYKAAMRMLPAQFTDVATQLAGGQSPWLILLQQGGQVKDSFGGMIPMFRGLAGAITL
+PMVGATSLAVATGALAYAWYQGNSTLSDFNKTLVLSGNQAGLTADRMLVLSRAGQAAGLT
+FNQTSESLSALVKAGVSGEAQIASISQSVARFSSASGVEVDKVAEAFGKLTTDPTSGLTA
+MARQFHNVSAEQIAYVAQLQRSGDEAGALQAANEAATKGFDDQTRRLKENMGTLETWADR
+TARAFKSMWDAVLDIGRPDTAQEMLIKAEAAYKKADDIWNLRKDDYFVNDEARARYWDDR
+EKARLALEAARKKAEQQTQQDKNAQQQSDTEASRLKYTEEAQKAYERLQTPLEKYTARQE
+ELNKALKDGKILQADYNTLMAAAKKDYEATLKKPKQSSVKVSAGDRQEDSAHAALLTLQA
+ELRTLEKHAGANEKISQQRRDLWKAESQFAVLEEAAQRRQLSAQEKSLLAHKDETLEYKR
+QLAALGDKVTYQERLNALAQQADKFAQQQRAKRAAIDAKSRGLTDRQAEREATEQRLKEQ
+YGDNPLALNNVMSEQKKTWAAEDQLRGNWMAGLKSGWSEWEESATDSMSQVKSAATQTFD
+GIAQNMAAMLTGSEQNWRSFTRSVLSMMTEILLKQAMVGIVGSIGSAIGGAVGGGASASG
+GTAIQAAAAKFHFATGGFTGTGGKYEPAGIVHRGEFVFTKEATSRIGVGNLYRLMRGYAT
+GGYVGTPGSMADSRSQASGTFEQNNHVVINNDGTNGQIGPAALKAVYDMARKGARDEIQT
+QMRDGGLFSGGGR*
+
+>unf122_NODE_11#PROKKA_00281
+VFDGELSFALKLAREMGRPDWRAMLAGMSSTEYADWHRFYSTHYFHDVLLDMHFSGLTYT
+VLSLFFSDPDMHPLDFSLLNRREADEEPEDDVLMQKAAGLAGGVRFGPDGNEVIPASPDV
+ADMTEDDVMLMTVSEGIAGGVRYG*
+
+>unf122_NODE_11#PROKKA_00282
+MFLKTESFEHNGVTVTLSELSALQRIEHLALMKRQAEQAESDSNRKFTVEDAIRTGAFLV
+AMSLWHNHPQKTQMPSMNEAVKQIEQEVLTTWPTEAISHAENVVYRLSGMYEFVVNNAPE
+QTEDAGPAEPVSAGKCSTVS*
+
+>unf122_NODE_11#PROKKA_00283
+MPVPNPTMPVKGAGTTLWVYKGSGDPYANPLSDVDWSRLAKVKDLTPGELTAESYDDSYL
+DDEDADWTATGQGQKSAGDTSFTLAWMPGEQGQQALLAWFNEGDTRAYKIRFPNGTVDVF
+RGWVSSIGKAVTAKEVITRTVKVTNVGRPSMAEDRSTVTAATGMTVTPASTSVVKGQSTT
+LTVAFQLEGVTDKSFRAVSADKTKATVSVSGMTITVNGVAAGKVNIPVVSGNGEFAAVAE
+ITVTAS*
+
+>unf122_NODE_11#PROKKA_00284
+MKHTELRAAVLDALEKHDTGATFFDGRPAVFDEADFPAVAVYLTGAEYTGEELDSDTWQA
+ELHIEVFLPAQVPDSELDAWMESRIYPVMSDIPALSDLITSMVASGYDYRRDDDAGLWSS
+ADLTYVITYEM*
+
+>unf122_NODE_11#PROKKA_00285
+MAIKGLEQAVENLSRISKTAVPGAAAMAINRVASSAISQSASQVARETKVRRKLVKERAR
+LKRATVKNPQARIKVNRGDLPVIKLGNARVVLSRRRRRKKGQRSSLKGGGSVLVVGNRRI
+PGAFIQQLKNGRWHVMQRVAGKNRYPIDVVKIPMAVPLTTAFKQNIERIRRERLPKELGY
+ALQHQLRMVIKR*
+
+>unf122_NODE_11#PROKKA_00286
+VADFDNLFDAAIARADETIRGYMGTSATITSGEQSGAVIRGVFDDPENISYAGQGVRVEG
+SSPSLFVRTDEVRQLRRGDTLTIGEENFWVDRVSPDDGGSCHLWLGRGVPPAVNRRR*
+
+>unf122_NODE_11#PROKKA_00287
+MTKDELIARLRSLGEQLNRDVSLTGTKEELALRVAELKEELDDTDETAGQDTPLSRENVL
+TGHENEVGSAQPDTVILDTSELVTVVALVKLHTDALHATRDEPVAFVLPGTAFRVSAGVA
+AEMTERGLARMQ*
+
+>unf122_NODE_11#PROKKA_00288
+MSMYTTAQLLAANEQKFKFDPLFLRLFFRESYPFTTEKVYLSQIPGLVNMALYVSPIVSG
+EVIRSRGGSTSEFTPGYVKPKHEVNPQMTLRRLPDEDPQNLADPAYRRRRIIMQNMRDEE
+LAIAQVEEMQAVSAVLKGKYTMTGEAFDPVEVDMGRSEENNITQSGGTEWSKRDKSTYDP
+TDDIEAYALNASGVVNIIVFDPKGWALFRSFKAVKEKLDTRRGSNSELETAVKDLGKAVS
+YKGMYGDVAIVVYSGQYVENGVKKNFLPDNTMVLGNTQARGLRTYGCIQDADAQREGINA
+SARYPKNWVTTGDPAREFTMIQSAPLMLLADPDEFVSVQLA*
+
+>unf122_NODE_11#PROKKA_00289
+MTSKETFTHYQPQGNSDPAHTATAPGGLSAKAPAMTPLMLDTSSRKLVAWDGTTDGAAVG
+ILAVAAD*
+
+>unf122_NODE_11#PROKKA_00290
+VTAELRNLPHIASMAFNEPLMLEPAYARVFFCALAGQLGISSLTDAVSGDSLTAQEALAT
+LALSGDDDGPRQARSYQVMNGIAVLPVSGTLVSRTRALQPYSGMTGYNGIIARLQQAASD
+PMVDGILLDMDTPGGMVAGAFDCADIIARVRDIKPVWALANDMNCSAGQLLASAASRRLV
+TQTARTGSIGVMMAHSNYGAALEKQGVEITLIYSGSHKVDGNPYSHLPDDVRETLQSRMD
+ATRQMFAQKVSAYTGLSVQVVLDTEAAVYSGQEAIDAGLADELVNSTDAITVMRDALDAR
+KSRLSGGRMTKETQSTTVSATASQADVTDVVPATEGENASAAQPDVNAQITAAVAAENSR
+IMGILNCEEAHGREEQARVLAETPGMTVKTARRILAAAPQSAQARSDTALDRLMQGAPAP
+LAAGNPASDAVNDLLNTPV*
+
+>unf122_NODE_11#PROKKA_00291
+MKTPTIPTLLGPDGMTSLREYAGYHGGGSGFGGQLRSWNPPSESVDAALLPNFTRGNARA
+DDLVRNNGYAANAIQLHQDHIVGSFFRLSHRPSWRYLGIGEEEARAFSREVEAAWKEFAE
+DDCCCIDVERKRTFTMMIREGVAMHAFNGELFVQATWDTSSSRLFRTQFRMVSPKRISNP
+NNTGDSRNCRAGVQINDSGAALGYYVSEDGYPGWMPQKWTWIPRELPGGRASFIHVFEPV
+EDGQTRGANVFYSVMEQMKMLDTLQNTQLQSAIVKAMYAATIESELDTQSAMDFILGANS
+QEQRERLTGWIGEIAAYYAAAPVRLGGAKVPHLMPGDSLNLQTAQDTDNGYSVFEQSLLR
+YIAAGLGVSYEQLSRNYAQMSYSTARASANESWAYFMGRRKFVASRQASQMFLCWLEEAI
+VRRVVTLPSKARFSFQEARSAWGNCDWIGSGRMAIDGLKEVQEAVMLIEAGLSTYEKECA
+KRGDDYQEIFAQQVRETMERRAAGLKPPAWAAAAFESGLRQSTEEEKSDSRAA*
+
+>unf122_NODE_11#PROKKA_00292
+MTRQEELAAARAALHDLMTGKRVATVQKDGRRVEFTATSVSDLKKYIAELEVQTGMTQRR
+RGPAGFYV*
+
+>unf122_NODE_11#PROKKA_00293
+VNISNSQVNRLRHFVRAGLRSLFRPEPQTAVEWADANYYLPKESAYQEGRWETLPFQRAI
+MNAMGSDYIREVNVVKSARVGYSKMLLGVYAYFIEHKQRNTLIWLPTDGDAENFMKTHVE
+PTIRDIPSLLALAPWYGKKHRDNTLTMKRFTNGRGFWCLGGKAAKNYREKSVDVAGYDEL
+AAFDDDIEQEGSPTFLGDKRIEGSVWPKSIRGSTPKVRGTCQIERAASESPHFMRFHVAC
+PHCGEEQYLKFGDKETPFGLKWTPDDPSSVFYLCEHNACVIRQQELDFTDARYICEKTGI
+WTRDGILWFSSSGEEIEPPDSVTFHIWTAYSPFTTWVQIVKDWMKTKGDTGKRKTFVNTT
+LGETWEAKIGERPDAEVMAERKEHYSAPVPDRVAYLTAGIDSQLDRYEMRVWGWGPGEES
+WLIDRQIIMGRHDDEQTLLRVDEAINKTYTRRNGAEMSISRICWDTGGIDPTIVYERSKK
+HGLFRVIPIKGASVYGKPVASMPRKRNKNGVYLTEIGTDTAKEQIYNRFTLTPEGDEPLP
+GAVHFPNNPDIFDLTEAQQLTAEEQVEKWVDGRKKILWDSKKRRNEALDCFVYALAALRI
+SISRWQLDLSALLASLQEEDGAATNKKTLADYARALSGEDE*
+
+>unf122_NODE_11#PROKKA_00294
+MEVHKKQLADIFGASIRTIQNWQEQGMPVLRGGGKGNEVLYDSAAVIKWYAERDAEIENE
+KLRREVEELRQASEADLQPGTIEYERHRLTRAQADAQELKNARDSAEVVETAFCTFVLSR
+IAGEIASILDGLPLSVQRRFPELENRHVDFLKRDIIKAMNKAAALDELIPGLLSEYIEQS
+G*
+
+>unf163_NODE_15#PROKKA_00295
+LPDPLPRARNTPTYQPAGYVFEDVEHAADLFNLQTFGFIYSRLTNPTVAVLEERIANLEN
+GRAAVCAASGHAAQFLTFFTLLEPGDEFVASRNLYGGSITQFGLSFKRLGWTCHFVDPRD
+PENFRRAITPRCKAIFLEQLANPSGIVIDVEPVVDIAHEAGLPLIVDNTVPTPYLFQPFD
+WGADIAVHSTTKFLGGHGLALGGAVVESGRFDWGQNDKSPGMVNPEPAYHELVFHETFGD
+FGFTTKARAVALRDFGPALSPANALYTITGIETLPLRMERHVQNAQAVAEFLDGRQAVAC
+VSYAGLPSSPYRALASKYLPKGAGAVFTFGLKGGFEAGVKLGGAGELFSHLANIRDTPSP
+VLHPASTTHRQLSEEQQLASGAGPEVIRLSVGIESVDDLIRDLEKGLAASQS*
+
+>unf163_NODE_15#PROKKA_00296
+MSDRSAQLSLGFSCLGHAYSHMFAPIFYVAALTLENDLGLTHGEVVGLIVIGNVLFGVAA
+PLAGWLGDRWSSTGMVGLFFIGTGGGMVMTGLAASPIQIGLSLAVTGLFASIYHPVGIAW
+LIRNARARGKALGINGVFGGAGPAAAPLIAGALIEISGWRAAFLVPGAVIAGTGVLFYWM
+MARGMVVETKQDALPLPPASRQDTVRAVSVLAVTLLCTGLIYQATQPALPKVFSERLAEI
+LGEGVFGISVFVAAVYFTAGGLQILAGHLADRYPLKFVYLVCFILQVPLLVLASAVSGAA
+LVVVAMAMVSVNVGALPAENSLVARYAPSNWRGLAFGIKFILAFGISGLGVKLEGVLYDH
+TGGFAGLFIVLGASAAVGTAAALLLPSDSRVKAPVAAE*
+
+>unf163_NODE_15#PROKKA_00297
+VIIIGTTWHSLRDMRNPLKDEGPDPIDRYVGSRIKGKRTGLRISQGNLGKSIGVTFQQIQ
+KYESGANRVGSSNLYKISKALGVDVSFFFEGIEAQLEASKSAAAAGMSDQPMVRLEMEPM
+NSRHASELAHNYFRIADPQVRKRLFYLVRALVGDESLSDDSGGDTDDDIILDDDDMSMKN
+PYDMGGSGD*
+
+>unf163_NODE_15#PROKKA_00298
+MRNIMIVAGLLVVSAASGGGLYLAQSEPESLSLEVASKQGARAEKARVFGGRAKATAPTL
+DGKDGVDSRSRATVARTGASQPGQVGGSGPEGGRIRGSAGGPIAARPSGVSETHHQPGEV
+LVANPPPNFENMVVSQGYRIGDLLQLRSLDMRVLRLRTPSNVSVASAVQRLRQQFPRTTT
+DANTLYELSQGQGFPESYARMLIGWPGVPQNCGAGVHLGMIDAGVQPDHPALAGTDIRYR
+SFHQPGRQPGPANHGTAVAAMMVGKPLPGKGWSGLLPGARLSAANIFQLGANRKIAASAR
+GLLEAIDWMAEQRVDVVNMSIAGSNNKVVREVVEKARAKGLVLVAAAGNWGTAKRPAYPA
+AYGDVIAVTAVDADRRIYEFANSGQYIDFSAPGVRVWTAIPGGGQYQSGTSFASPYVSVL
+TGLIVSRGHPRDPEAVRKTLRAKVVDLGAAGRDDVFGWGLVDMQPRCVKLARAEVWSDTV
+NR*
+
+>unf163_NODE_15#PROKKA_00299
+MPGVVWSIVASGVAVQNRWHTLAITMATVVEQMVANKVVGMMPAGSVEPAATLKAMTPVG
+SRGTLEVLMARNRAMALVAVPLMGFSLSSSCRARMPNGVAAFPRPSTLADMLRIIAPIAG
+*
+
+>unf163_NODE_15#PROKKA_00300
+MAGSLMMDARMPYAPEPESGRNRAMGSASAGNPNSSVSDPSGVIKRASAPLARNIATATR
+MATRYGMMRIATWKPSRAPSTNTS*
+
+>unf174_NODE_16#PROKKA_00301
+VVIGVNDRGEKHFLAIEDGVRESTQSWREVLLDLKRRGLTVPPKLAVGDGALGFWAALDE
+VYPETRHQRCWVHKTANVLNCLPKAVQPKAKKALQEIWMAEDRASAHKAFDHFVQMYQAK
+YPKAVACLEKDRDALLAFYDFPAEHWVHIRTTNPIESTFATIRHRTDRTKGCVSRNTMLA
+MIYKLGMSAEKRWRKIRGFSYLAKVINGVKFKDGTEVNSKDRNSREAA*
+
+>unf174_NODE_16#PROKKA_00302
+MTIKNIFQVRLKPTRITFYATGLGILSIFLSLMLNIFPTDLGHWIFRIIFQISIVGLVAP
+LYLLSNNNELKPAGLRYNKAYVYLLISIGIAGSLLFLFWTEDNKLFSKFNTQSFEPAAYI
+AVANVYEVIFFVVFLRYYFEKAFGILPAIVLSSLFYSFHHAGFQPEFAKLFFVGLVFFSI
+FRVANHWLICFPFWWVGGIVDVLTKAKDISDISGLTWGKSLFVLTVIIVSVAYFQRSSRN
+AFASR*
+
+>unf174_NODE_16#PROKKA_00303
+MSPFSLWISNSFYLATIFYLLSLAVLVWPRRWLENLLLGLGLACNLVSMGIRLYYSWPMQ
+APYQEPFWLTACLAAFALCLSLARRQRLVRWLIPVIAGLALLAALFPKDYYLPFPRSNTI
+FSHLFLFLSASGKACLWVAGMDALRFALGVDEYRAAGNRRPLFLKLIVWGFVVYTLSLFV
+AETWSYLGWSSPVIWEDNNLPATMGTWFYYGCFLHLYLLRGWGLRRRAWFAVVGMALLFY
+FNYLPETGEFKLPVSR*
+
+>unf174_NODE_16#PROKKA_00304
+MALLKSIWDFWGRPGLTFVLLLCLVADAYAGFFLVRAQPDIFASLNRLMHHDWLATYGWH
+SLEITWWFFLLLVLMFLLVMNTLVCTLQKVLLLIRHRRRNQDRLGYVLRCSPHVMHLAFI
+VILASHLISYAVGINSQNNVVRKGGVIPLPGSPYRLRLDEIQVKFYEGRRLDFFRGRAVS
+QRISLTLFDRQQRPTSKVLAINPPIWYRGYSIHLKRYYPSRRSGMRRAPYANLIIRKDPG
+ITMFFTGTAIFTLGLLAYLWQAVRERRRETPGDPAREATHAVV*
+
+>unf174_NODE_16#PROKKA_00305
+MRWFSLFCLALILLIPPAAAWAKAGGCESFGPFSVRTLPQGRSLVPDASGREFHLVPRGQ
+KPPAGVALVQVVFIPVKRVAMSGGQDVSLLITLHAMDTRVALTGGRPEDWVLEPVRKGLD
+QGRIVSLGGNHAIDYEQLATIKPEVFFTWDESLIPTAAALQVPVVITYGELARNLETQIK
+FVRFLAPFFGREKEADQYVARVRAAVARVRERAKGVKHRPKVIWGDIYEKRVLVEPGHSW
+AAEIVRLAGGDYLFDDVRGTS*
+
+>unf174_NODE_16#PROKKA_00306
+MITYRTPKQGITTKAQLAKINPEMAAIRPMTQGRVFYPRKIYKQSGHRLDEIIEEVAAML
+HPELYPGHKLKFFGELR*
+
+>unf185_NODE_17#PROKKA_00307
+MIIPMLCVTIFVILVVWFLLPRVARLMIHTPTAISIFVCLSMVQLMAVFISMRCTLCGHF
+LQVALTLILVVGYAIAAS*
+
+>unf185_NODE_17#PROKKA_00308
+MAVNIHITIIELNALHTKRQNLFQELDAVIHLLMEAKHWGLRKSRNATSLNSRFKSLDTL
+KVKIISVTFRRVIRTNHKKASKIWRHENIQLGGCQS*
+
+>unf185_NODE_17#PROKKA_00309
+MKNINHTRSSISDDIRNILCSSANMRRAIPLILRLLMNSVNLSTNLASHFFDLVIGKILT
+SRLSLSKHLAHNLGNLLLLGKIGVFHNRRNASSRLLLLISKHLILCIYLVFRILA*
+
+>unf185_NODE_17#PROKKA_00310
+LHLGNLFLIVQLHFSKLFLILKSGVNHTSRGSISTSTLPSIKLRKCSSKIITSILSFISG
+RLATKSNQIKQLIRNGRSASLQRTFKKSFTSFSHSTRNKTRDGLIRVRNIRALNGRFNTS
+ITHAYSIVIGSKHITLNATGGGFLTASKQFRHGATSKSRSNTASNSTKHKSPHLSGWRQI
+ISLIT*
+
+>unf185_NODE_17#PROKKA_00311
+MSNIQTGAERMPHDLSHLGFLAGQIGRLITISTTPVIAGDSFEMDAVGALRLSPLRRGLA
+IDSTVDIFTFYVPHRHVYGEQWIKFMKDGVNATPLPTVNTTGYIDHAAFLGTINPDTNKI
+PKHLFQGYLNIYNNYFKAPWMPDRTEANPNELNQDDARYGFRCCHLKNIWTAPLPPETEL
+SRQMTTSTTSIDIMGLQAAYANLHTDQERDYFMQRYHDVISSFGGKTSYDADNRPLLVMR
+SNLWASGYDVDGTDQTSLGQFSGRVQQTYKHSVPRFFVPEHGTMFTLALVRFPPTATKEI
+QYLNAKGALTYTDIAGDPVLYGNLPPREISMKDVFRSGDSSKKFKIAEGQWYRYAPSYVS
+PAYHLLEGFPFIQEPPSGDLQERVLIRHHDYDQCFQSVQLLQWNSQVKFNVTVYRNLPTT
+RDSIMTS*
+
+>unf185_NODE_17#PROKKA_00312
+MSRKSIVIKQEFRLLGYELNRSGLLAENEKIRPILAQLEKLLLCDLSPSTNDSVKN*
+
+>unf196_NODE_18#PROKKA_00313
+MDPNLVIPVQQIEDDLRMLSRYNRCIRTYGVGQGLDRVPEVAQSLGMTVMLGAWISPNAS
+DNSRELGLAIDVANRFPDTVSALVVGNEVLLRGDLSEQKLVEHLRETQNAVSVPITYADV
+TDYWFRHRGVADSVDFVTIHILPYWDDDPVGVEDTMVRVRTLWEQARAVFPDKRVFVGES
+GWPSAGRMRGEALPSRVNQARFVRELLNLAQSENMDINLIEAFDQPWKRVNEGTE*
+
+>unf196_NODE_18#PROKKA_00314
+LFSEPREEKWPLMGPVSDDASWRAHLAWSIAIAVLPMLSVLVFLGNLTPVRWLMLALASH
+TAACTLVVAMLNVFQTTMTPIDWAIGLARWGLEAAAFALTVAAFVEASKKGGGKPWVPAF
+RDIVVALRARTFRAFRGLGFALGLVRALTLFGAAVVTLGLIFDARYRDFPVAVYAVPAVA
+FAVLALYRLDARSADFREEVLLALILAAGGIAITVLEGVANHQAMAWAAVNFVLAGTIAY
+DVFSRRRAG*
+
+>unf196_NODE_18#PROKKA_00315
+MKPPIFSFPVIVLASAIAAMTVGAAVRHGIVQYKAIHNICADAIDFWPCEIRSLVIMTLM
+NTPVLGLLALALGLAALIGNRRALIIAALVTGGLGLFLYNTELGACGLLLGALGAVRADV
+RSTG*
+
+>unf196_NODE_18#PROKKA_00316
+MRIKIAITIVLTVSVVLVAMQPIRSPAAERLGSFAIDPGAISISGVSSGGFMANQFHMAH
+SATLMGAGIIAGGPYQCARVNSGFGDYLGSYKELWNAIYICSHQAGQIPFIGFMQPFLGP
+PDPKKSVGAARAEAETGAIDALENMRGDRVWLFSGTRDTLVPTSVVDAVDASYTELQRAF
+TDRPEDTIVYVNDVDVHHAMVVAHKGDNNCLEFALPYINDCDYDAAGNMLTFFYRRPETS
+LNPPGEWDRRSLSAFDQTEFFPDGSGRDENGDGSISMNDIGHVYVPANCRAGTTCRLHVA
+LHGCEQYQEKVERECGEEGKCEPRLFFETAGYNPWAEANDTIVLYPQTIPWDGPSVTRTN
+PKGCWDWWGFSGEDYATKNGKQIRAIKSMIDRLTGS*
+
+>unf196_NODE_18#PROKKA_00317
+MESGNLFDGMPGTPIAEEAMATVLETPGFRLVRIVSTGQATPYGDWYDQDEAEWVMVARG
+RAGLLIEGEGDARTMAAGDHVLIPAHVRHRVEWTDHDQPTVWLALHFSE*
+
+>unf196_NODE_18#PROKKA_00318
+MREFLAEKWTQILIIASIGVAWITFTALVG*
+
+>unf196_NODE_18#PROKKA_00319
+MRTAGGGNKRGEKATIQGGWPEGPDEGAMQATTYKTLSQENIADVFPGTAKGQATSASRA
+RLKALLSKIGGRDTPLERPGVWHQIPYEPPCDEPVRSLPGREERAKVGPLPGPLAKNAAR
+*
+
+>unf207_NODE_19#PROKKA_00320
+MSQPNQAKSAPEGEMSYRQASEQMIWNLRLDFDPVGIRFVFDENERDFLPVSHRAKARIT
+YCQFLAAARQAHYSFFMEPHQCVCGNAQPVFGFRELDKESDTKRHMKYLCDEELAWQAPQ
+EKARLEVGALKGIYIAPLSKFDDLEYSPSLAFVMCLPYQAYHIFNDYMGAMRRPNLTFFH
+TPNSAVCSGSVYAFNHDTANMTTMCAGSKTSGKSEMAYVNVFIPGDQFLRTAQQQKYRIE
+EMGGPSLLGKGGQPWPGLDACKGCPLFKFEALS*
+
+>unf207_NODE_19#PROKKA_00321
+MALVTLENVGKTYHMDEVEVTALAEISLSIEQGGFAALVGPSGSGKTTALNLMGSLDKPT
+TGKVLVAGQDVSALDRKNGAAFRGQKLGFIFQDFNLLPVLTVAENVEYPLLMIRNLPKSQ
+RGPAVARVLEAVGMNDQADKYPAQLSGGQKQRVAIARALVGEPALVLADEPTATLDGATA
+QRVIELMKRMRDEFGTTFVFSTHDPRIMDQAEALFHLEDGRLVDSPQTGEEVGHA*
+
+>unf207_NODE_19#PROKKA_00322
+MLKVIRLALKNLLRYKRRSLLTGLLIAFGVVALIIFVGLSDSFKRAVVGQITDSVLSHLQ
+VHRKGYMASIDNLPLDRMLHPKAYKKLTSVLSREPGVEAFSPRIKFGAMLSNYAQTTNVR
+LNGIDPAREQAAVPLLKSRIKSAAHPDVLLAPGEVLLPETLAKGMGLKTGDTVVLVANNK
+DGSVNGMTFKVAGVVESLMGPGGRDGYLPIKGADKLLRLAEPELSEVAVRVRNFVRLGEA
+AARLRGVLEPMTNQKGKPMFELHTWTQLTPFNNVVRMIDLMNVGIKVILVAVVLISILNV
+MMMSVYERVREIGALAAMGTSPGRIRGLFVAEGFCLGLASSLAGAAIGLGVLAVMSLAGV
+EIAFGRSNEVFALAPSIAPTEVISAVLIVLAVSVLASLQPAAKAARLEPVEALRHV*
+
+>unf207_NODE_19#PROKKA_00323
+MFKNTEKALVNITLRLFLLGCIILSMMLAAPAWALSGQEILEQVDHNLLPGDLEMYRKII
+NIEPSGAKKEFVLWFLRKDKDKVVVRVPRLFPGGIL*
+
+>unf218_NODE_20#PROKKA_00324
+MNVEAVLKTRGANVVTVAPGDTVVAVARLFGEKKSGIAIVCDAASDVIGVVSLGDIVHAV
+GAKAADALEQPVETIMTKDPAVCKPGDDIESALNTMEELGIRHLPVVEDGKLKGFVEQRA
+ALETLYEDAALDFAQLRSYVIRPGGRR*
+
+>unf218_NODE_20#PROKKA_00325
+MDDLFSRITTASEKARTRTQPKAPAKPRAKPESNARPRAPGRARDEEQGQERGYTAEDIE
+VLVGLEPVRRRPAMYVGGTDDRALHHLVAELLDNAMDEAVAGHASRIELELALDNRVTVR
+DNGRGIPVDPHPKFKDKSALEVILTTLHSGGKFSNKVYHTSGGLHGVGVSVVNALSDILT
+IEVARNRNLWTQSYARGTPVGPLANQGQVSNRRGTTVSFHPDPDIFGEKATFRPAALYRL
+ARSKAYLFRNVEIRWSCDPALLTETDTTPAMDVLRFPGGLRDFLVSTLKNRPALTPTPFA
+GQSDTAGGIGRVEWAVAWPEDEEAFFRSYCNTVPTPEGGTHEAGFRAALTKGLKGYADLV
+NNKAGCKITPEDVVGGACIMLSLFIPEPQFQGQTKEKLTNSDAARLVENSVRDHFDHWLS
+GAPDMANVLLDALVDRADLRLRRRQDKQTNRKSATRKLRLPGKLTDCSSTSAAGTELFIV
+EGDSAGGSAKQARERKTQAVLPLRGKILTVASASADKQRGNQELNNLTEALGCGLGAAFD
+LSALRYEKIIIMTDADVDGAHIASLLMTFFFKKMPKLIEKGHLYLAAPPLYRLSRGTTTL
+YARDDAHKDEIMSTAFKGNGKVEVSRFKGLGEMPPQQLRATAMDPATRTLLRVTLPEGTE
+SPGPDDAEAAENLVETLMGRKPELRFQYIQKHARFVDEIDV*
+
+>unf229_NODE_21#PROKKA_00326
+MTSSHHGPYDQGYTRATMAHTKRSDLARASGPHKVRRSPDWSLQLDSMKSESLVIVDQNA
+TVNTFPGLVHTARHTMGVGCKRSR*
+
+>unf240_NODE_22#PROKKA_00331
+MFKKIRLGTKLLVAFLVVGIIPFATIGLYSLSMSSKALSEQAYRQLESVREIKKAQINKF
+FLERRGDMGVLVDTVSAMTHEAFQKLAVVQQLKKTALEKLFGQIEKDVLALSKTTDIVRF
+FRALRRYSKETDCKPDGPFDVTSQRYQAISSIYSGFLHAYVKIYGYYDVFLIDAATGQVM
+FTDAKENDLGANLKYGKLKDEGLGRLWRKVVESKRVAIEDFSPYSPSKNQQAAFVGAPVF
+EGTGELVAVVALQIPIEPITSIVDQRQGLGRTGESYLIAKVGGRYQFRSNLKTMGGGKYV
+IGHDASVIATDYLNMALEGKQGVGIFLDSRQQPNFVAYAPLDIKGLHWALISKITTEEIL
+ASRLRGEKKDFFAKYIDKYRYHDLFLIAPNGYCFYTVAHEADYHSNLVSGRYAASNLGAL
+VRKVIQTRRFALADFAPYAPSNGKPAAFIAQPVLRQGKVELVVALQLSLDAINEIMKQRA
+GLGKTGETYLVGPDKLMRSDSYLDPKNHSVKASFANPAKGRVDTEAVREALAGRTGEKII
+IDYNGNPVLSAFCPVKVGGITWALLAEINQTEAFQAVYHLKRAMLIIAVVGIVVIILVAF
+FMGRSISKPIKRVAESLGGGAEQVAAASEQVSSGSQTLAQGASQQAAALEETSGSLEEMS
+SMTRQNAESAQQARDSSQQVAQALEEANELMAQTAESMTEIKTAGEETSRIIKTIDEIAF
+QTNLLALNAAVEAARAGEAGAGFAVVADEVRNLAMRAAEAAKNTAKLIEGSVRNINKGAE
+LLDKTRESFETVVKQNRRVGELIEEIAAASSEQSQGIEQINRAVAEVDKVTQQVAANAEE
+NASASEELSSQAELMKEMVGELVSLVQGAAARRERASLNDDAPKRGNGRQRKLALLPGPQ
+KGRDLEVEGDSSDF*
+
+>unf240_NODE_22#PROKKA_00332
+LACVRRPEIMCGLHQRASFVTGDLEAVRSPMGAACSNLITWPLHYLARGENKAVLGGWDP
+AARKFFKTDELSLTVPWSMFLAMLERWQDSFLSTNAGRTVLKKVARSARTWGED*
+
+>unf251_NODE_23#PROKKA_00333
+VWRTLEDLDLATPNVGLVTDIISCPGMDYCSLATARSIPVAQRITARFGDIARVHDVGEL
+KIKISGCINACGHHHVGHIGILGVDKKGEEFYQITLGGDASENAAVGKIVGPAFSYDEVV
+DAVETVINTYVEQRKEGERFLDTYARLGLEPFKEKLYGAH*
+
+>unf251_NODE_23#PROKKA_00334
+MALIKNGQPVQDPWIAVADDGGLPSSGSVIVSLARWRSDRDALSNRADPVGIRLASHETA
+SDIASGLNRVSLVALEFPTFRDGRAYSTSRLLRERYGFAGELRAVGNVLRDQLLFMHRCG
+FDAFEIASDDAVETCRKAFEEFSAWYQPASDGRAPVTALRHIRRAAE*
+
+>unf251_NODE_23#PROKKA_00335
+MTTMRSATAAAENEQSVVAEAEIRARLLAEQYRGADTRQLLAAMISEEYQGRIVLVSSFG
+AEAAVLLHMVSEIDTATPVVFVNSGKLFGETLRYRDQLVERLRLSDVRTVGPEPDRVDQV
+DPDGVLWYGNPNMCCYIRKVEPLQRALDGFDAWITGRKGFQGGDREGLPIIEAGDDGRIK
+VNPLAGWEKQAVDSYFADHDLPRHPLEADGFLSIGCMPCTDRVAPGEDARAGRWRGKSKT
+ECGIHLPRANWKVMGID*
+
+>unf251_NODE_23#PROKKA_00336
+MALNCKTPADVLQVVKENEVNYIDLRFTDPRGKWQHLTMTSDFVDEDAFADGIMFDGSSI
+AGWKAINESDMALIPDATTAVMDPFSAQAELILFCDVVEPSTGQPYGRDPRSVAKKAEAY
+LASTGVGDTAYLGAEPEFFVFDDVRFAVEMNNCFYEFSSDEGPYVTGRILPEGNAGHRPP
+IKGGYFPVPPVDSCQDLRAEMVTVMRDMGLTMDKHHHEVAPSQHELGMTFDTLVRSADNV
+QIYKYCTHMVAHTYGKSATFMPKPVAGDNGSGMHTHQSIWKDGNPTFAGSGYADLSDTAL
+YYIGGIIKHAKALNAFTNPSTNSYKRLIPGFEAPVLLAYSARNRSASCRIPFSSNPKGKR
+VEIRFPDATANPYLGFAAMLMAGLDGIQNKIHPGDAMDKNLYDLPPEELSGVPTVCGSLR
+EALDSLSADREFLKKGDVFTDDMIDGYIDLKWEEVYNFEHTPHPVEFQMYYSS*
+
+>unf251_NODE_23#PROKKA_00337
+LHACRSTLEDPTRKQPRNTRIELIVDDDLVEQAIDSILQAARTGRIGDGKIFVSTVEEAI
+RVRTGERGTEAI*
+
+>unf262_NODE_24#PROKKA_00338
+VCPQNRLTALIGPSGCVKSSFLLLWSRMNALIPGTGVEGRVLLKGVDLYGPGVDPVEGRR
+RVGMVFQKPNPFPKSIYQNVAYGPRLHGLRDRRELDRLVEESLKAAALWDEVKDMLHRSA
+LGLSGGQQQRLCIARAIAMQPEVLLMDEPTSALDPIATARIEELVGELKKRYTVVIVTHN
+MQQAARVSDTTAFFYLGRLIEVGPTEKIFTRPDQEQTERYITGRFG*
+
+>unf262_NODE_24#PROKKA_00339
+MTPDESSRFHRRMEEVREDLLGMAGLVEAAVQDAFAALSQRDSTRARHVLEGDRRIDLME
+NQIDEKALVLLATQQPVAVDLRFLSAALRICSFLERIGDQAVNLAWRALALQEMEPKELP
+AKLHDIYTISRGMVRSCLDALVGGDRELARQVIELDDEVDDLTRDMLVEGIEAMQQGRED
+LRRGVELILCSRHLERIADEATNIAEEVVFLVEGRVIRHGGPEPSVGPL*
+
+>unf262_NODE_24#PROKKA_00340
+MQDFASVNEILDFAIEREKEARDFYRSLAEEVSARHMKELFKSFAAQEQKHADKLLAVKS
+GGGLTPSGETVPNLKLSDYLAEADMSEQIDYQDALVMAMQREKLSFKLYINLAALAVNPV
+VKDTLEALAQEEARHKLYLELEYDEQVLTEN*
+
+>unf262_NODE_24#PROKKA_00341
+VSRTKTEIQGLIFDFDGTLAELNLDFEAMRQGVHRLAREAGFDGDWPGGYLLEEIERLDR
+RPELAETGFATRALELIQAIELEAAGRGRLFDFTRPMLARCRELGFGLAVVSRNSAAAIR
+RVFPDLERAVDAFLPREAAPRPKPHPDHLLRACRRLRLEPSRCAMVGDHPTDLEAARAAG
+CMAVGVISGRTPAAALEEAGADLVLPDASALAVVLGSEAACMSIARQS*
+
+>unf273_NODE_25#PROKKA_00342
+MNQVISAPKMPLRRRVKSPVNSPSRAAETAPANMPTQGEIPRRTASRAEV*
+
+>unf273_NODE_25#PROKKA_00343
+MLRSLLARLFDWLRTAAGMTILATIVITVAATIDRGPCILVKGIVTGGMLALVSMGLALV
+FGVMSIPSFVHGEYFMIGGLTAYFIITPLQTYLQAHPSGLLNLLAPFIAIGGATVVGAVA
+GSLTERLVFRELRRRNRTNWVMNCFLLTVGLNVILVNGHQLLFGADFKGIVNYFTGAPLQ
+VMGVYVSPARTIAFTLSILVIVGFGMFMRYTKTGRAIRAVSQDETGAMIVGINLEGIMML
+TMALGCALAAVAGSSLLFMYPSYPTSGLEPLYLAWFVVIIVGLGNVMGALVGGFMVALFK
+VLTVEYIGSGWDFVVPSALIMLVLLLKPNGIFGSEVRGVLDQ*
+
+>unf273_NODE_25#PROKKA_00344
+VLLEVKNLNAGYGFLQILRDVSLKIDQGEYVCLIGPNGAGKSTTMKTLAGLIKPISGEIT
+FEGESIAGLPGNQVTSRGISYISEEMNLFTNMTVHENLLMGAYTIKDKQAIARQLDFVYS
+LFTRLEERQKQLAGTMSGGERKMLAIARGMMSRPQLVLVDEPSFGLSPQMTQVVFDSLES
+LKQSGVTILVVEQNVNLSLSVTDRGYVIENGRIGIEGKSSDLADDPYVRKVFLGV*
+
+>unf273_NODE_25#PROKKA_00345
+LVESPGRENPISETLTPAHPKRRARARARAGSPRLIFLDELAAGLTEGELKDIIKIIRKI
+QDSGVTILMVEHIMQLIMNVCDRLVCIQFGTKIAEGPTEEVARDPKVSEAYLGAAH*
+
+>unf284_NODE_26#PROKKA_00346
+VKLSRWGEEYYGDLGEPLGSFEGETQTVMSVGDLAYWEPGNAFCIFFGPTPASSGPEPVA
+ASQVYPLGRVEGDWQALSALGASVTARISAA*
+
+>unf284_NODE_26#PROKKA_00347
+LHLDQDQQDFLRHIQQVVETQLAPLALEIESQSRFPQQAREIFARAGLFTLAVPRSYGGQ
+GADATRLALMVENIARVSPSAALLVFPSNAVLRTIALTGSEEQKERLFGELVQAGDQCLA
+FCLTEPDYGSEAFNLQTRAERQGDHYVVNGTKTFITLGPNARYYLTFVRTGPAPKAGGIS
+ALLIPHDAPGLGFGPPEKKMGLHGSVTTNMYMKDVPVPVANRLRGEGEGWQVLTRVCNPM
+RVWGAAAMALGTAQGLFDQTLAYVKANAERLNPADRQSRDFALADMKMRIEACRSLIYRV
+CRMVDDPRTPPQQVDAFVSMSKCYAADTGMETGELASRILGMDLMRPDCLAGRLYLDAKA
+IQIFDGTNQIQRLVVAKSLALG*
+
+>unf284_NODE_26#PROKKA_00348
+MDFELSEELKMLREMAADFAKEQIAPYADKWDEEHYLPHEEVIKPMGELGFFGTVIPEEY
+GGNEMGWLAAMILTEEIARASSSLRVQINMLELGCAFTIYRYSLHDEVKKKYIPKLVSGE
+WLGGFGITEPNAGSDVMGMKSTAVDKGDYWLLNGSKTWISNADIANCIIYYAYTDREARG
+KGLSAFVLDLKNEDGSRPEGISVTRLDKLGSHSSPTGEIYLDNVKVPKENILGKPGDGAK
+IVFSSLNQTRLSAAAGGVGLAQACLDESIKYANEREQFGKPIAKQQMIQDQIAQMAIEVE
+AARLLVYKAACQKDAGNLGNTLEVAMAKWKAGEVANFCAQQALRILGAYGYSTEYPVARF
+YRDAPTYFMVEGSANICKWIVALDALGLRKANR*
+
+>unf295_NODE_27#PROKKA_00349
+MSHRPRNRKLLPRFIALLVLALVLLLCSVAPAAAWQDFSFLALGDTRTEPYLAGGRDQAT
+RMKQILRQRYRTEAQLFFTPDGSALERAELQHKGARYTLYYQDGWPERIEVTKGGATRTI
+MHAAGRRWVFREMLNDIKPGAPLPEEGARFILHGGDLVLNGYLGTSPQSPYWGLLKKELL
+DRLPPADAALGLPGRVMVCVGNHETWEDPKLAGLLGTMPWLRELGFSEHNRIYAVDYQNC
+RFIFLDTGGYSPLGTRWLGQYPPFKAQMAYLRRLLKDAVIQGLDHVVVLFHKPAFVKVGH
+DPLPADQNPHYLLKGFAPLIDILVISSHTHTTERYQVDGINYLVLGAGGAPQKFKDCKHP
+SPQPELYWRGKPRVEEYNYLKIDVKGKEMVGWLHRWRPGGDKPHGQWVEFFRSRTP*
+
+>unf295_NODE_27#PROKKA_00350
+MTQEDEQAYRRLLVDRVMAHHGLNRRAYQRAWPSSTRPARLWLEGQPYRVKDLSQGGCSF
+LVQEAPPDGGWVRRGALELPDGGVPLPVTVVVVAFQPGGLVRGAFLGLDDEAKRRIQRFV
+AGRTGELVAEATPENEPS*
+
+>unf295_NODE_27#PROKKA_00351
+MPLARKRKSAQKISDFTRVYLMRHPEVVGHYEGKFWGHSDVSLSRYGKAQMKAMAQRMGQ
+EKLAAVYCSNLQRTRQVAEAIGRIQRPRLKPQADPAFRELNLGIWEGLTYQDISERYPDQ
+LAARARDLANFAIEGGESLAQLSQRVLPAFWSMVEQNRGKEVCLVAHAGVNRVILVEIMG
+APLENVFRLDQEYGCLNIIDIFEDGIPLIKLLNQAIEV*
+
+>unf306_NODE_28#PROKKA_00352
+MTAATDVLHYDNANLRRILRDYRNIAMIGASANWVRPSNFAMKYLQGKGYRVIPVNPKDA
+GETIHGEPVYARLADVPGPIDMVDIFRNSEAAGSATDEAIALAGALGIKVVWMQLHVRNA
+AAARRAQAAGLEVIMDRCIKIEYGRLFGEIGWSGVNSRIISAKRPVLHP*
+
+>unf306_NODE_28#PROKKA_00353
+MTESTPETTTESDAPVLLRHDVDGIATLTLNRPDKFNALSVALLSALETELEALADDASV
+RVVILAGNGKAFCAGHDLQEMRACPGRQSYKALFEQCGRVMLAIPRIPQPVIARVHGVAT
+AAGCQMVATCDLAVAVEQARFAVSGVNLGLFCSTPMVALTRNMPRKQAMEMLLTGDFIDA
+ETALSYGLVNKVVRRDRLDETVAELADKIAGKSSAAIALGKQLFYKQLEAGMEAAYELAS
+ETMTCNMLTEDAETGIDSFINKQPLPPWKGR*
+
+>unf306_NODE_28#PROKKA_00354
+MREGADEVDVYVNVKYLRRQRTNQKYGERADVPAISVEEFNEIIRTDLTWAFDMGMQADK
+IGAGTAVLRLPYRASMLRPGGVIAGPMMMALADACMFAVALSLIGEVKLAVTTSFNINFL
+HRASPGDLLAEGRVLKKGKRLMVADVTVHSEGHDLAVAHATGTYSIPPINGGR*
+
+>unf306_NODE_28#PROKKA_00355
+MPIIHWTEDLSVGTDTIDADHKVLIDMINRLDEAIKSKEPQGTVNRVLSELLDYTGYHFD
+REEALMKAAKYPDYEAHARTHGILKAQVADIRSRYERNPNSIHEREVLAFLKNWLTAHIL
+GRDKLYAPFMESRREDVDKANEAFTQSSGV*
+
+>unf317_NODE_29#PROKKA_00356
+MIVTLSPRRRHTSNLHPSNPVKDLTLEQLKGIYTGKIRNWKEVGGQDKPIVVISRDSSSG
+TFEVWNHKVLKKARVRPDAQLQASNGAVAQAVAGNKYAIGYVGIGYLNPKLKALTVNGVK
+ASPNTAMSGTYPVARSLYMFTPGEPKGEVKKFLDFVKGPEGQKIAAQEGFVPLK*
+
+>unf317_NODE_29#PROKKA_00357
+METSAQAAAASPTGTAAGAAGETPSYRRGARSDAWMRRVFLGAGLVSVGTLALIVLFLFR
+EGGGIFKVTSLSDFLSGHYWYPTYDPPDFGILPLVVGSLAVTALSSALAVPLGVATALYL
+AEVASPRTRELLKPAVELLASLPSVVLGFVGMVVMAPLLQDWLDIPTGLNLFNASLMLAL
+MAIPTITSIGEDALQAVPRELREASLALGATRWETLSRVVMPGALSGLGTAVILGMSRVM
+GETMVVLMVAGGAAQIPHSIFDSVRPLPSTIAAEMGEAPVGSDHYVALFAIGIVLFLITL
+AFNLVAARISARFQQKGAATL*
+
+>unf317_NODE_29#PROKKA_00358
+MTGFSLRARRLRQAVAFGLLRLAVLMVLASLGGILFFILVHGAGAITWEFLTDAPRDAMT
+KGGIFPALVGTLYLTVGAILVSLPLGVAAAIYLSEYARPGRLLNLVRLGIQNLAGVPSVV
+FGLFGLALFCVVFGLGTSLAAGSLTLGLLILPTIIGAAEEALRQVPDTFREASLALGATR
+WQTIRKVVLPAALPGILTGGILGLGRAAGETAPIMFTAATFYTLHLPSSPLDQVMALPYH
+IYVLATAGTHIEQTRPLQYGTVLVLIGLVLGLSLTAMVVRSRMRRKQRW*
+
+>unf328_NODE_30#PROKKA_00359
+MTTVLETHNLTKRFGGLVAVNQVSMHVDEGEIVGLIGPNGAGKTTLLNAIAGLNPPTSGK
+VSFFGEDTTGLPPEAMCHRGLSRTFQIPQPFPQMTALEAVMTAAIFV*
+
+>unf328_NODE_30#PROKKA_00360
+MSGKKRYWVIVALAAALMMMLPGQALAGKVFKLGVLGPFTGPSAKTGAEFKGSVKMAMEK
+IGYKIGDYKIELVWIDSQSDPAKATSAYSEACERAGIQAGVLNWHSSVAIAVMEVAAQYK
+VPHFFGFGASEVVNAKWHKDKKYHYWGGKGWPVPGKLMAGYVDCLNYAVKQGKLDKNNKT
+VAIYGEDSDWGRSVGKAFRERFTATGWQVISADYFPLTQTDFYPLLSKYKKAGVAVVAGT
+STSPPSISAFVKQASEVGLKATIVADGLGWIGDWYKMTGNGSNYVLDMIPQLTTKKSREW
+AKEVKAKFGYNPSPSSGGLSYDGINFMIKLLKRTLEREGKLDKESVYKVMIDEVNTGKLT
+YTKADGAIIMNKYQYTPKTMPDMVLGPGAYFFPVIQYMNGKGAIVYPKDWATKEFEAKK*
+
+>unf328_NODE_30#PROKKA_00361
+VVDIRSQNGKVQGVTLKDGTKIDAPIVINAAGPHSFVVNAMADGVLEGMNIKTKALRHEV
+HHVPSPEGFDFLNDGYHTSDGDNAIYFRPEVGNMILVGSEDPECDPQQWIDDPDNFNRQI
+TDAQYKAQVYRLARRIPSLRIPNKHIGIADLYDCSDDWIPIYDKSDLGGYYMAIGTSGNQ
+YKNAPVVGALMAHLIEACEKGHDHDSDPVQYPLKYVVGRTLDVGFFSRKREINPESSFSV
+NG*
+
+>unf339_NODE_31#PROKKA_00362
+VVGNLLRDMGYSLQANRQTREGTNHPDRDAQFGYINDQVKQALAAGQPAISVDTKKKELV
+GDFKNGGREYRAKGQPEPVRVHDFVIPELGRAAPYGVYDIAGNAGWVSVGIDHDTASFAV
+NSIRRWWQTMGQARYSQATQLLITADCGGSNGARVRLWKRELQALANELGIAITVCHLPP
+GTSKWNKIEHRLFSFITQNWRARPLVSYQTIVQLIAATTTDTGLRVQCEIDTNTYPAGVK
+VTDAEMDSINIQRHHFHGDWNYTINPQIPIRSDSS*
+
+>unf339_NODE_31#PROKKA_00363
+MTDDDLFLCNWRNLFHPDRAFMLRWLPPPQRAALEARMLQDYHATIANLTGTDHGKPRAD
+*
+
+>unf339_NODE_31#PROKKA_00364
+MATMNVHIDHRPGGVGVLTLARPPVNALNPHFLKDIENALQELKADPGIRALVITGAGKT
+FSAGMDLKEVQAFTVDDQTAMVEVLSRVMARLYGFPKPVIAAINGHAIAGGLLLVLGTDF
+RVASAGAVVGLAEVRVGVRFPLAPLAIVRRELSPGALRRLVLSGNTVAAEAAERMGIVDD
+VVETEAVIDHARAVAEELAKTPPETFAAVKSQLRSETLKSMDHIMDRRLDPLLRGWFSDE
+TKDAARAILAARTK*
+
+>unf339_NODE_31#PROKKA_00365
+MFGLFKKSDKPKIDAAEIERREREQRKREMAEQMKQTVQSEKEDQQASQKS*
+
+>unf350_NODE_32#PROKKA_00366
+VLARILVPGGVLVINVPHPRPGHWLERLRRRPGLTDQWHGHLRPGYRLDQLRAMLGGRFE
+LERHTHYHGLFCELVDTALNFMYMSRQKNKQTSAKGLVVTAEDWGRRSKEAKLLKAVHPL
+LKAFCALDALVPRGWNYSLVVRARRR*
+
+>unf350_NODE_32#PROKKA_00367
+MKVLVTGGTGFTGSALVRRLIQEGHQVVALDYREGIMLDRLRRLGAEIMIGSVTDRELVR
+RAMHGVEVVHHLAAAFRELNVPESHYYHVNVDGTRNVVREALEHGVRKFIYCSTCGVHGN
+IDNPPGGEDAPIQPADYYQQTKYLGEEVVHELGDPAGLDYTILRPAAIYGPGDPERFYMI
+FKWVKKGYFPMFGSGKTFYHPLYIDNLIDAFMLAMEPEAGRGQAYLIADEHFYPIKELVK
+RVAKAMKLPVKILHFPLPPVILAGHVCEKVCKPLGVVPPIFPRRVDWYRQNRAFKIDRAK
+ADLGYRPRVGIDEGLRNTAIWYREEGYL*
+
+>unf350_NODE_32#PROKKA_00368
+MVRLYSYVIVYDTGFAPNPFWDFCTLACCKARLRNSARLGDWIAGFASKTYELVFAMRVD
+EILSFAEYYLDKRFALKIPDFSKNNPVYHCGDNIYKPLPNGGYQQLRSFHSKNCSPEENH
+QTKADDLKSENVLISQHFHYFGSKATPVPPKFDQLVYKGRGYKYNFPSDLVKQFLDFLDT
+LPMGVNGSPSGLQADICSDRGNGCSPVCSAKMPPSCC*
+
+>unf350_NODE_32#PROKKA_00369
+LLDCHSAVTPFRDDVSINGLLELCGRDLSIDPRRVAGIQAAVSRYLPWVKGLKPELVWTG
+LRPCCPDGLPIIGRLGGLSNLLVAGGHDQKGISLAPVTGQLIARLLQGRPLGGELDEALS
+PNRF*
+
+>unf361_NODE_33#PROKKA_00370
+MQWFRLYQEFANDPKVQIMSEAMQRRLVMLMCYRAQDMITDDGLPMDEEELAFALRISDE
+ELAETKKLFIRKGFIDENWRILNWDKRQQRSDLSTERVRKHRLKKKQEKQPEEAVLGTPE
+ETGGNGDETFHETDETVTETGRNVTETEGETKCNGLDKTREEKTREEKTRETMEFTSPSY
+SSTTSQNKTTKSSKAALSTSAQKSIIEAYHEECPDLPRVSKLTDQRKSKLKSRCREGPER
+LEPDWWRSYFRKAASQPFLVGRNDRRWKANFDFLIRSEDVVVRVLEGSYGDGRSAENPYA
+DL*
+
+>unf361_NODE_33#PROKKA_00371
+MATAAVLKIHTRTCEEHVCPQCGGEVKPVSLPPMLGMSAREHWPALCGRCADLAEQEQER
+MQRRADMERLFEASNLPPAARRWNLITTAAMADRQGLNAVEAWEYGPMGLYLHGPAGSGK
+TVLAWGLIIREIAVQLRSCLFLGVPELLYRVRMGFSKADAVDWLARGRQVRLLVLDDIGA
+EKPTEWVRETLLSLINHRIDYELPTVFTSNYALGELHEHIGDETGRLTNRIAGNCRVVEV
+KTRSFRLDKARAMKGLH*
+
+>unf361_NODE_33#PROKKA_00372
+LPRKRRLIPKGTPGRLIWLLFAWFEHRTVIEHPKARWPRFAKRWFFDGNALVGVDGVCLI
+PSTAPPEVSDVEEFGVGFNKLPDLDRKILEALVFNAAQGWPPEPDNSEDEDWITALDKLN
+LSSRSYERLLRDALRRLTDETRRRGLLEA*
+
+>unf372_NODE_34#PROKKA_00373
+MEQALCAHGAYDVWERIRDCGTDRKRCGSRYCINCFNRYVTSQTVLVKKLFDNYATEVDQ
+RTNIRQLTVLFDAFDFDLHSKPHPTICAQRLDKAREYARKELDALKRHFPSIRIVGALEL
+EPINGSTKALRKDSTAIDALLAIGAHRDTTPSLYRIFTAPGMQRWTKHLILYHGHFVVDL
+NGTDDKDFRVWCHERWGHNRPKNPVKRGAHVQRLYKDRTIGQSLRTLARYPLKTPFNYHV
+PKNNCGQPSTGLIRYEDAILSAMIVDDDRIGIRGVKVKKGT*
+
+>unf372_NODE_34#PROKKA_00374
+MTGGLGHVHGERPGRRVQPLGLGAVGVAPPQRRPFIVLGAEEAFTLDPHRQIEQRGEDHA
+HILRSICDQLFHKGLNGRIVLAPHVWFSMLDWSLSWNTKKTDRPTEGHAPRWGSKRKLQP
+NFQTSGYTSGMRAWELKEDYDLEKHVLGEPNSRSGIRGPKLTLHHINKLKRMKAARRAEH
+NAKQALWQMMYGHEEIRERDLDRREADLEARQHELRLREIVAGIDKAIADAEAEEESKQH
+LHAMATREINRRKKKS*
+
+>unf383_NODE_35#PROKKA_00375
+MRKIETVRDLRGEAYKILRQAIADGTLPPGQRLKETDLARDLSVSRTPIREALQQLSKEG
+FVVITPRQGAYVRRWTREEALEILLIREVLEGLAARLAASSMSFPDIERLARHIEDFESG
+RIDYAESDRRFHEDILRACGMRRLIGLIRNLYDGIQMFKVLNTSFQSPERIRQSIEEHRS
+IIRAFRAKDPDLVEQAMRNNFRHTRGFIAKFF*
+
+>unf866_NODE_7#PROKKA_00376
+MQVYPKFLLSATAPAHFPPPSAPEFAFLGRSNVGKSSLINALLGSRQAKVSSTPGRTRAI
+NFFSLTTSPNRQQPNFLFADLPGYGYAKISKSISAEWPKVV*
+
+>unf866_NODE_7#PROKKA_00377
+VKKVWLSWSSGKDSAWALHILRQQKDVEVVALLTTLNEHFDRVAMHSTRRDLVEAQARAA
+GLPLVRVPLPWPCSNEQYEAAMGKACAKAVAEGVEAVAFGDLFLEDVRQYRVEKLAGTGL
+EPLFPLWGLDTRALAREMIAAGVKTRLVCVDPRKMPREFAGRDLDEAMLRELPEGVDPCG
+ENGEFHSFVYGGPMLGEEIPVESGEVVERDGFVFADVKLKH*
+
+>unf866_NODE_7#PROKKA_00378
+VSEIQIVGVVGAGTMGNGIAHVFAKSGFQVRLCDVEQRFLDRGMDTIRKNLGREVTKGKL
+MQEEADAAVKRIEGTLARAALADCDLIVEAATEQLEVKRQIFEDLDRVAKPEVILASNTS
+SISITKLAAFTERPERVIGMHFFNPVPVMKLVEVIRGLATTQETFEMVKALAERLGKTAV
+EVNDAPGFVSNRVLMPLLNEAMYAVMEGVATPEAVDQVFQLGMAHPMGPLTLADFIGLDV
+CLDIMRVLQEGLGDPKYRPCPLLIRMVDAGWLGRKSGRGFFEYGNA*
+
+>unf866_NODE_7#PROKKA_00379
+VLASGSKGNSTVVSSSRTRLLVDAGLSCREIFRRMQAAGEDVESLDAILVTHEHQDHVQG
+LAVTARKLGIPVYFTEATHRAWMRWMTPRKRLTYAQWLEQQKAIVAAGKEPAAAGAEAQD
+AAEEDISGAKPKKDPCALPAVEYFSSGTDFQVGDIAITPYTVPHDAADPVGFVFEAEGVR
+LGIATDLGYVTPNVHLHLKKCDVLMLESNHDVDMLRDGPYPWSVKQRVMSRVGHLSNDAA
+ADFLENSYDGRAAFVVLAHLSESNNLPELARVSAERALRDRMNLLGNKLMLASQQTPLEP
+IVL*
+
+>unf866_NODE_7#PROKKA_00380
+MKTCIDPVVGDILSSWRYDISGITPEMRIDYEEHLASCSVCRSRQRLHRAIDVVLIGLTT
+LSTIVFVLALAVIHHVEPLRTFALFIFHIRDFSVVLTLQAVAFAGLVVSMFAWLLVAVAT
+PVPTFLSGVAREQARELQSRIPEEWRNRFQRGAL*
+
+>unf866_NODE_7#PROKKA_00381
+MAKGRMEIRPFAFAVDPVCGWGLLPGLHAANQL*
+
+>unf866_NODE_7#PROKKA_00382
+MSATRGIQHGVDMRVEVADIQLPNPVLAASGTFAYGIEFEDVVNLDHIGGFVTKGISREP
+LSGNPAPRLIETAAGMINAIGLQNIGADAFVQQKLPALARYQCPVIVNIFGYQMQDYIAV
+IRRLNEAEGIAAYELNVSCPNTHAGGIAFGIDRAALSDLVAHARHYSRRPLIVKLSPNVT
+SIATMARSAESSGADAISLVNTFVSLAIDVETRRPRLSNITGGLSGPAIKPIALRMVWEA
+AQAVKIPVIGMGGITTPEDAVEFLLAGASAVQIGTASYADPRAVEHIGQGLAHWCSRHHI
+AKVSELIGGMQTGQ*
+
+>unf866_NODE_7#PROKKA_00383
+MTKNQDCMTLPVRWEQAPAREDFWQELRTASRWLLLLDYDGTLAPFHQDRMKATPYAGVK
+ERLEQLLKIEKGRIVVISGRQIEDLKQLLQLSQPVEIWGSHGREHLLHDGSYRLVDLTED
+ERRVVEAVTARMSERGWAGQLERKPTAIAVHWRGLPVSEQKELREAAEQYFAEANPPDTL
+EMMPFESGVELRSRSRTKGQVVAEVLAEEPADIPTAFLGDDWTDEDGFAELRGRGVGILV
+RPEARESCADYHLTPPEELLEFLDRWLENAKESIR*
+
+>unf866_NODE_7#PROKKA_00384
+MSENQVIIVSNRLPLSMTVKFGSLKVGRSSGGLVTALQPILKSRGGTWIGNGGTREDKRM
+ARALEEEARRSGFDCVPVFVTEQEDRNFYEGFSNQVLWPLFHDFIGECRFEPEYWDFYRK
+VNGKFADAVMRVYNGKQILWVHDYQLMHVAASLRERGCKGRVAFFLHTPFPSYDVFAKLP
+WRRHLLLAMLEYDLIGLQTERDVRNLVSCLRRLVPEASMSTDHGVHRVSWHGRTVVIQDF
+PISIDFDEFARAANQPAVEERMRTILARMGMGQVIFGVDRQDYTKGIPHRLRAYGELLRR
+RPEMVGKVKLVQIVVPSRQNIPGYEALKSRIEHLVASINGEYTQPGWVPIHYIHRAIPRE
+ELLALYRAAHVGLVTPLKDGMNLVAKEFCASRIDDRGVLVLSEFAGAAAEMYRGALLVNP
+FDLEGVADALEQALQMPGAQQQERMRKLRRFLKHANVHRWVEDFMEEIESVKAPRSRRG*
+
+>unf866_NODE_7#PROKKA_00385
+MSMKVTTRQVDGVTILDLSGRILLGEGSVQLRDAVRDLLAKGQKKILLNLGDVTYIDSSG
+IGEMASALTAVRNQGGDLKLLNLTKRVHDVLQITKLYTVFDIKDDEASAIASYN*
+
+>unf866_NODE_7#PROKKA_00386
+LRGQQETRVTYTLASSLDSVDKVEQTAEQMARNAGIDEDEAFRVSMAVREAAVNAVLHGN
+AYAPDKRITVTFENNGSDLIIHIMDQGEGLDPAALPDPLKPENLLSGSGRGIFLIRSFMD
+EVHFKQLHPGTELTLVKHLGTAKQSLQGGNSL*
+
+>unf866_NODE_7#PROKKA_00387
+MPVRLMPMPEVDAKVTLTMLLGTPVTDATGKLRGKVRDVAVATGAEAGRVAGLVVKNRDG
+LQVVTSVDLRRTPSGTLELRADAQMRPLTGEESFLLLRQDLLDRQIIDVHGRKVVRVNDV
+ELDWWNQERGAAGQQESLRVTGVAVGLRGALRRLLLGLMPQATLDRLARKVPQRSIPWEF
+VDIVEVDPARRVKLKIEHERLARLHPSDIADILEDLAPAEREALLRSLSEELAADALEEL
+DPKLWRSLLQSMDSETAAGIVEEMDPSAAADLLADLSKADSEAILGEMDPEERQEVKELL
+EFREDSAAGRMTTEYVAVPEDATVADCVAALREFEGDPETITEIYLLGEDDLLVGVVPLA
+RLVLAREETRAQVLSEPETITCELEAHQNEVAELFDKYNLRALPVVDEQRRLAGVVEADH
+VIAFLRERR*
+
+>unf866_NODE_7#PROKKA_00388
+MLKRWRTRILLFLAVLGPGIITANVDNDPSGIFVYSQAGAKFGYELLWTILPVTLALIVI
+QEMCARMGVVTGKGLSDLIREEFGLRITFVMMVLLVVVNFGNVIGEFAGIAGSLELFHMT
+KYASVPVCALLVWLLAVKGDYKRVEKIFLVGSVFYIAYVATGVLAAPNWHLSILKTVTLP
+HRSVWRQDGYLFMVISIIGTTIAPWMQFYLQSSVVEKGIRVQDYAASRADVVVGSFFTDV
+VAWFIIVACAGTLWVHGLGKINLPSDAAVAMRPLAGNYAFLLFALGLFNAGFFAASVLPI
+STAYTVCEGLGFESGVDKKFSEAPFFYWLYTLLIVGGAAVVLIPHFPIIEFSIFSQMLNG
+ILLPIVVVFMLLLINRKDLMGEYTNSRWFNAVAWVTAVVVTVLSVVLMVQSIRQV*
+
+>unf866_NODE_7#PROKKA_00389
+MPNQCRHVRANGVQCRAHRVWKEDYCFFHLHHRTPNGTAKRSEDPPPPPPKNGIEIPLLE
+DLASIQIAIGRVLTALAQGKITSAEARTYLYGLRLAASNVKQKDFAPVNTVETYVQYDNG
+DTLGPEQFHAEKQPQHPLMDSGLLALRHLSNRLTYEATLDAYLTQGQEPPSTLRPPVAGP
+PADKSELQNWIKTGWKACQSRAHALELARKAIDQPIPDPIDPKAAFSINANIQRTA*
+
+>unf866_NODE_7#PROKKA_00390
+MEKPTVIHSSFTLERSYPYPAEKVFAALADPEKKRRWFADSPNHEVVKFAMDFREGGAER
+MEYRFNEGTPFPGVMLVNSGHYEDIVPGRRVVLCSTMTIAGRKISVSLVTFDLLPQGEGS
+ALLCTFQGVFFEGADGPEMRKAGWEFLVERLGEEVAREG*
+
+>unf866_NODE_7#PROKKA_00391
+MRKRKPKVDRIFHALGDPMRRVMVELLRKRPYSVSALAEPLGITLTAVGQHLKILEEAGL
+VRTEKLGRVRTVQLEPEGFAVLEAWAAEHKGEWALRLDRLGDVLADDG*
+
+>unf866_NODE_7#PROKKA_00392
+VTTANTFRANWPFVLIAAIFLGTALVGALTGRIWLQMRTITRTNDKVMYWATIWCSVIMA
+GFMLLVAAHYAPVINLIKEL*
+
+>unf866_NODE_7#PROKKA_00393
+LHLSVSERTIAPARNIEGSLRLPGDKSISHRYALLSGLAEGTSRFTNFSTGADPSSSLAC
+VEALGAKVVRGEDGSVEVTGVGGQFQPSSSPLDCGNSGSTMRMLAGFLAAQQGEFTLVGD
+ESLSRRPMERIRKPLMQMGANISLTEGHAPMVIHGIPLKAMEYATPVPSAQVKSAILFAG
+LQASGTTTVRESVRTRDHSELALRAFGAELERTIDSITIAGGQKLSAIEAKVPGDISSAA
+FYLCAAALFPGSNLVFDDLGMNPTRASLLDVLTALGAHIGVIDLEDKASELIGTVKVNAP
+PDGLTGTTVSGALAAQLIDELPVLAAIGPYTNNGIRIRDARELRVKESDRIDLVVKNLRA
+MGAEVEEFEDGLDVPGGQTLHGAEIDSGGDHRIAMAFSVAALRAEGETLIRGAECASISF
+PEFFDLLDAIAQR*
+
+>unf866_NODE_7#PROKKA_00394
+VNVLRKSFVVAVVLLSFGASAAVAQTTVAASVYGAFRSSTRTGGISNFTVENPSNAAGFL
+LELRHISNPLMGYELTYSYHRANEAYSNTLKVLCPISPGGSCPEQITTAGVSANAQEVTG
+DWVVSFPLANLKPFVLVGGGVIVTSPATGSVTATITDFDPVTNMMSQTTSSMPTQTQTKG
+VFQYGAGLDWTVLPHIGLRFQYRGNVYKAANLTKVFTSTDKFTQTAEPVVGVFFRF*
+
+>unf866_NODE_7#PROKKA_00395
+VYESRPQTTPEQHSSSIEGSHPTDAAAAAGSRSVELAQTDFLLRLTDALNTTLNLQTLLQ
+RTADLVRTVIDYRIFAILLLDNRTNDLRMRFQTGHRPEVERMRIRLGQGVTGQVALTRKP
+MLIPDVRDVENYINANPDVHSEIAIPLIVKNRVIGVIDIQSEQPNYFQPDHLHLLTLTAS
+RIAHAIDNARLYTRVSRQAQTLEVLNEISRDLSSILDTDRLFERISQLLRRLFDYQMFTI
+WTVRPIEHVLENRFALRFGERYYPNETIPVERGIVGAAIAERRPMNIPDVRRDPRYHKVN
+EETRSELAVPLMYKSKVVGVLDVEHTQPHYFSEDHVRALTTLAAQIAIAIENAQLYQRVI
+QQEQRLDHDLQMAREVQLRLLPPSLPSRPHAEFAARFLPARTIGGDLYDYLNYDDQRGAL
+AIGDVSGKGAAAALYGAVVSGTMRSQASLKPSPAAMLQALNASLHERRLDSQYVAMLYTV
+WNDENLTLQIANAGSVQPIYCRSGEIETVPVEGFPLGMFPQAEYEEISLSMRPGDSVFFF
+SDGITDGENEAGESFEERLTDSIARHHHLPAEEAVNAVFEELQEFQGDCDRFDDETLIAL
+RVV*
+
+>unf866_NODE_7#PROKKA_00396
+MPDQTQFPPAESLRIRFTRDQIQSRVREMGRHIREDLHGESVVLVGVLKGAAIFLADLAR
+AINLDCTFDFVAVSSYKSGTRSSGAVQLIKDLTEPIEGRHIIVVEDILDTGVTLSFLQSH
+FERHNPRSIRVAALLDKPSRRIRPIQGHYIGFSIPNEFVVGYGMDYAERYRNLPDIRILD
+SIPAS*
+
+>unf866_NODE_7#PROKKA_00397
+MYPFIHIGHFTIPTYGIMMWLAAVAGCIVLYRNFKRWKVEGDAITIVAFATVIGIIGGKL
+YHVLEKPVLLMHHPALLISRSGFAWYGGMIAGILALLFQAGTYNIRPLRMLDLCVPSAAL
+GYGIGRLGCFFSGDGGYGPPTKMWFGMSFPHGTVPTTQKVYPTPLFEFVAAVIIFYILWR
+RSRPAAERKLGHMTAEYLLLAGGARFLFEFIRINPKIFLGLSNAQWASIAEMLGGTALLW
+WSRKYASTPQPGQQGRQPKEEPALVAAGDSGGPPTAEQTQ*
+
+>unf866_NODE_7#PROKKA_00398
+VSACSHRPDARPLRIGQAQKDLRIPANKLHQEASPAGPQQILGRHLSQLPRRPRPAPPPE
+DIEDNAGPDKLKNRRRIHFLCCRHNSVRIAHPEPHLRRNAVIPVSGQLASNAPDSVPQRR
+RGHAQIQHPQGTNLIGPGLEQQRQNPGNHPAKPGKPGPADQQRWMMHQQHWLFQHMVELC
+AHHSSHRRKGDDADRIGINLPALEVLVKEVAPDHRGKPHHDAVCANR*
+
+>unf866_NODE_7#PROKKA_00399
+VRLAQDAPVSFDPDTFKVTPPDPAVITPVLAQLEFNQLLNQFAAPPPKADYRRLSDPEEI
+EDFLKPVARKKRLAIDTETTSIQPMLAELVGVSLCHQAGEAVYIPVAHNLTPGQSQADKE
+AVLQTLAPVLADPAVTKIGQNIKYDLIVLGRCGMEINGPLFDTMVASYLLNPGKTSHNLA
+SIAAEFLGRSVISYQEATGGKNRPFADTDLDQATDYAAEDADVAWQAAQVLEKKLAESHL
+DGLFRDLEMPLVPVLARMERNGVGLDVQGLEDLGKELAAKLDEIERTCYRLAGHEFNLNS
+PKQLAQVLFEELGLTPVKKTKKGKTSSTDVSVLTVLAAKHPLPAEVLNYRTLSKLKSTYI
+DTLPKLVNPQTGRLHTSFNQAVTATGRLSSSDPNLQNIPVRSEIGERIRACFIAEKGNLL
+VSADYSQIELRVLAHLSRDPLLVEDLTKGLDVHTQTAARLFDVMPELVTKPMRARAKTVN
+FGILYGMSAFRLAREQGISRKEAQQIIDKYLGRYQGVARFQEENLRQAREKGYVTTLLGR
+RRYLPAINAGDRLARQAAERMALNTPIQGTAADIIKLAMLAAHRLLEERFPQALMILQIH
+DELLFEVPASQAEDLAQAVKQAMEGVIELAVPLVVDIGIGPDWAQAH*
+
+>unf866_NODE_7#PROKKA_00400
+MDHGKHKLATRLIHAGEPQEPVEGAVTLPIFQSSTFVYQGQASYHDLKYIRLNNTPNHRA
+LHHKLAALENAESALVTASGMAAISATLLALSKSGDHLLCQDCLYGGTLDLITKDLAALG
+IGHDFLDPERPESWAELLKPTTRLIYVETISNPLMQVMDLEAVVGFAREHGLVSVIDNTF
+ATPVNFRPAEWGFDLSLHSGTKYLNGHSDIVAGAVIGRAELVERITHKLNHLGGSLDPHA
+CFLLHRGLKTLAVRMDWHNRSAQRLAEFLAGHPAVTRVNYPGLPDAPDHQRASHLLDGFS
+GMLSFELRGGVAAAERFLSRVRLPYLAPSLGGVESLVTRPATTSHAGLSPQERQAAGISE
+SLIRVSVGLEDPDDLVADFDQALA*
+
+>unf866_NODE_7#PROKKA_00401
+MSAMGISRTVRRTVVLVAALSLLLSASAWAAPQRVAVLPFTANAKEDISYLVKGVRDMLA
+SRLAWQDKVVVIEPDLVAPVMKEVPPPYNEAKARKLGNKLSADVVVYGSITALGSTVSVD
+AQVIKVKGKQPPLSTFVQAADLNQVIPQINDFAKRINAEIFRRPEAVAALQKQGQQAEKG
+KQEAGSSGKPLVEAPKTPAAEWQQKRAVEVGKLPPNISPLNPLFLRSLSGVDSDRYWRSP
+RIDGVVSSLAVGDIDNDGRNEMVVLLHKRIRVYRLDGQRFGLIHEFKKGPDGEYLFVDIA
+DLDGNGRPEIFVSSIINGEIVSFVLEWGEGGLGIKAKDIPWFFRVQPNPTGKGNIVWGQG
+KSINAAFAGPVYRMKYENGQYVPGEPIRLPEYANVFNFVKADLNGSGRPMTVMVAPGFRL
+KVFGKPDDELFASGEMYAGSSKFIEVPSHSDPSNPGDEPAREFLPTRLIVNDLDKDGRSE
+IVVVRNKDSLQGIMENMQFFYQGTIYSLYWNGMSLLENWRTPRISGYLTDYTIADVGNVG
+RPALVLSVVQTKYGGMVEKGFSHIVAFTLKPQAKKKKHYIKRTKGL*
+
+>unf866_NODE_7#PROKKA_00402
+MTPLPRLTSRRGFPWPRKVHEEMERTYYQERSQHGHITGPGLVHVVYGQGVGKTSRCVGL
+AVRAAGAGLKVAWVQFMKDDTSSEVKVLRDLAGVHYFCPGPHAFITKKGPGDEHRQHARR
+ALEHARELVEKDRVQVLICDEILNTLLFKVLPLEEVMALVELCRGRVELVMSGADVHPDL
+LDAADYATELVQRKHPYYRGIEARKGIEF*
+
+>unf866_NODE_7#PROKKA_00403
+MPKPVISYHPALEADQSFLLRSRRPLERRDLLAILRAGAVLLPQAPRADLYLLVAGMGRP
+HFPRAAVYFSLDGKVGNHRLFSALGLPQPPTLSFENLEQALAAWREGGLEAAGITPPLVV
+KGAGGGEGSNVFLVRDIGELAGLAGRVETFCARGPSGLVVQKYLDGGGGDARVVLLGRSC
+EAFWRRSAPGEFRSNLSSGGRVDRRWRPAELERAVEPARRPQGATGVVVAAVEILVPPGG
+EPLLLELNFYFGRRALGGSETFLRRYLAAVRRWLEGLGLDPRRVQLYE*
+
+>unf866_NODE_7#PROKKA_00404
+MTTPRETPLENPYSQSGCFFCGQDNPVGLKLRFARVEGKEELVCRWRPDRRYLGLGRVLH
+GGIQCGLFDEIMGWTAHHFSQGPGVTQEVSVRYLAPLFIDRPLELRCRVVERKERRIFME
+AEIRDHQGRVCSRARGSYALMDPERFARLVQDQPEPPPAE*
+
diff -r 000000000000 -r 68a3648c7d91 pfam_search/lipase
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/lipase	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,162 @@
+<html>
+<head></head>
+<body>
+Proteins with PFAM domains:
+<br><br>
+<div>
+<table cellpadding="0" width=650>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>15FR_NODE_1#PROKKA_00113</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+VLAGIAEWYGEDEAVPFRVISGTSAGAMNAAYLSANMENFAHGTQRLAQVWSQLEAQQVYRPEYRKVFGALLHWAWSLLSGGLGDSNPRS
+LLDNSPLRALLAENIDFDAIARNIERGLLRGVSVTVAGYSTERSLSYFQAETGVQSWWRQRREGRPVQMTLDHVMASLGLPIIFPAVKVA
+GEWCGDGSTREFAPLSPAIHLGAKRVLVIDTQYPAPQHVLGQDQAYPSLSKIMGYLFDSVFSDSLYADLERTKRINRTLDYIKRQSGHEP
+PELGLSHIDTLVIAPSRRPLEIASRYESHLPKSMRWILRSLGGDVSSGDQLLSYMLFQSGYCSEMVALGRHDAHARREEIGQFLGLSKIK
+V
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01734> PF01734</a>
+<p align="justify">Patatin-like phospholipase<br>Pfam-B_2206 (release 4.1) This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of  the total soluble protein in potato tubers  . Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids  . Members of this family have been found also in vertebrates. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0323> CL0323</a>
+ <p align="justify">Patatin/FabD/lysophospholipase-like superfamily This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>16FR_NODE_10#PROKKA_00133</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MNPIEAISHTGRSVRSRLKGFPRKKVLVLEGGGMRGIFTVGVLQAFSERGYAPWKTIIGASAGALSGVVYAAGQIHMARDAFFTELISGR
+FIRMSNIFRPEKHILNLDWLVDHIIGGDEPLNIRRLRTTACPVLITVTRFSRDFPPDTLYLSTKTDSVPQALKATAAIPFFYRGFVHYRN
+DLLLDGGVLDSVPFKKALSMGFPERDILVVLTRPKGYRKERDSFWIKTLYESYYKDSQYRYLVNSLEHHFGNYNRMLDDLETNYDFDIIY
+PPDNFKVNRLTRSEDKIVDGFEQGVAAAKAYLKPK
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01734> PF01734</a>
+<p align="justify">Patatin-like phospholipase<br>Pfam-B_2206 (release 4.1) This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of  the total soluble protein in potato tubers  . Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids  . Members of this family have been found also in vertebrates. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0323> CL0323</a>
+ <p align="justify">Patatin/FabD/lysophospholipase-like superfamily This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>16FR_NODE_10#PROKKA_00142</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MGKTIRRALVLSGGGARGAFEVGVMRYLNEVNWQPDLICGTSIGAINGAAFGSGMSVDELAHLWKTYHRKQMYKITFPAFFRTLLSGRKF
+SPLSDNRPTRSLLEKTIDIDALRNSTTEIIISVLNMRTSQVRYFTHKAIGIEHLMAAGGIPMMFPWQYIDGDPYWDAGVMVNTPIMPAFE
+RGATEIIVVLLSPLGAIPQRLPSTHREVSELVFEQFLIGSYTACLPNAGWRTNPEADVYDTPLPDSPQLQLSMKGVRMATVYPTRMLGFR
+SLLDFSPRQAKTLLRDGYVNARMQLKSFF
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01734> PF01734</a>
+<p align="justify">Patatin-like phospholipase<br>Pfam-B_2206 (release 4.1) This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of  the total soluble protein in potato tubers  . Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids  . Members of this family have been found also in vertebrates. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0323> CL0323</a>
+ <p align="justify">Patatin/FabD/lysophospholipase-like superfamily This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>8FR_NODE_2#PROKKA_00232</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MGLSYRINFKLGANAMVISDPSMPVPASLQFRQLKSDEYVMLDIPTDSLEVAYWGTKKPVPAQYVLTEAQTAKVESAITSYNAEIKSLAK
+KYNLAFVDFNSIMKSIEHGGLTVDGIHFTTAFITGNLFSLDGVHLTPQGNAVVANYFIQAINKQYGSHIPSVMVSDYPSVVF
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00657> PF00657</a>
+<p align="justify">GDSL-like Lipase/Acylhydrolase<br>Prosite & Pfam-B_543 (Release 7.5) </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0264> CL0264</a>
+ <p align="justify">This superfamily contains a diversity of hydrolytic enzyme activities. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+</table>
+</div>
+</body>
+</html>
diff -r 000000000000 -r 68a3648c7d91 pfam_search/lista
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/lista	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,1 @@
+a
diff -r 000000000000 -r 68a3648c7d91 pfam_search/pfamA.txt
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/pfamA.txt	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,14831 @@
+1	PF00389	2-Hacid_dh	2-Hacid_DH; 	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family represents the largest portion of the catalytic domain  of 2-hydroxyacid dehydrogenases as the NAD binding domain is  inserted within the structural domain.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null --hand HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.50	0.71	-4.69	98	16860	2012-10-02 14:31:05	2003-04-07 12:59:11	25	50	4524	180	4691	12854	6366	308.20	17	85.12	CHANGED	lllhp....sh..pptshphlcc.........plphtp....shsp-..clhcthps..s-ulhstsps.....plspcll.pth..spLKlluptusGhDslDlcsAsc+GIhVsNsPs.ssspulAEhsluhllulsRclspspppl+pGpapppthhshphtspshsllGhsthGttssthtpthththhhhshhhs.pttpttthhhht.thhh...................psspllshps.tshppthhhtpptttthhsshhlsssttsshhststhtshtpptthsssshssppp.sshtp.LhshsNVllTPHluus..TpEAppshutpsspslhphhpG....psstssVs	.......................................................................................h.t.hpt..............h..pl.phhp.............hspp....ph..h....p...t..l...t.s...........s..-..s.l.h..s.p.st.s...........l..s.p..c..ll...pth............spL+..hl.u....p....h.u...s.G....h....-....s..l....D....l.s.s....A...p.c..........p...........G...........IhV............s........N.s......P.s......s...s..s....p......u.....V....A..EhsluhlLshsRplspsppph+pGpapttshhshthtstphtslshsthsthhtthtpthththhhh.hh.ttttttttthh..t..h..........................................................................................................................................................tst.hh.htshts.ppthhhspphhthhhsshhlhssttsshhppshhtshhpttthsssshss.tptsshtpsLhphsNVllTPHluus..T.tE.up.pp.hs.p...t.s.hpslh.p.hh.ps......t....p.l..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1361	2755	3878
+2	PF00198	2-oxoacid_dh		2-oxoacid dehydrogenases acyltransferase (catalytic domain)	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.	23.00	23.00	23.10	23.50	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.30	0.70	-5.09	100	10039	2012-10-02 12:01:53	2003-04-07 12:59:11	18	49	3997	65	2920	7770	5825	224.80	35	47.20	CHANGED	ssstpplPlsshR+slAcphspStp.shPphshs...s-l-hspLhplRp.p..................lppph..tt........KlohhshllKAsuhALccaPhlNush..s..s-s.....llhpcplslGlAVsos.....pG..LlVPVl+sscptulhplupclpcLsp+ARss+.Lpss-hpG.GTFTlSNlGsh.G.sphhoPIIN..PpsAILulGpl.pcpP.ls.tssp.........lshpph.....hsloLohDHRllDGAsuucFlppl+.chLE..sPttll.l	.......................................................t....ppl.h.stlR+tlApphhcuhp.ss.s..p...lThh...s-lDhst...lhshRp.p.......................................hpp.t.htcpps..............KLohhsahsKA.lstAL..+..c.a.P.tlNuuh.........s...............scs........llh+ph...hs..lG.......lAV..s...T..s............pG.....L.lV..P...V.l+..ss...-.p.h.ultpls.p.........c.l...pcLup....+.......AR.cG...K..Ls.....s...p-h..pG...GTFTI....oNhG...s........h....G..uh..h..T.PI....l.Ns..Pps.A.I.L.G.luph..tp+......P.ls....hssp................................lshcsh...h.LuLSaDHRllDGtpuu.pFLspl+.phLE..sPtthl.............................	0	940	1801	2459
+3	PF04029	2-ph_phosp		2-phosphosulpholactate phosphatase	Kerrison ND, Finn RD	anon	COG2045	Family	Thought to catalyse 2-phosphosulpholactate = sulpholactate + phosphate. Probable magnesium cofactor.  Involved in the second step of coenzyme M biosynthesis.  Inhibited by vanadate in Methanococcus jannaschii.  Also known as the ComB family [1].	21.70	21.70	24.00	23.70	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.39	0.70	-5.40	61	532	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	495	17	238	524	260	226.60	27	93.52	CHANGED	plplhhsscth.tt........pssVVIDVLRAToTIssALpsGAc.tlhPsssl--Ahthtpt......cshLluGE.RsGh+ltGFDhGNSPh-hp......tppl.....p.GKpllhoTTNGT+Alpcsp.sAp..pllhuuhlNtpAVschltpt.....scs...lhlVsuGhp.GpaolEDhlsAGhlhptLhpptt...........thsDtshsAhtlapp......ttshhphlppusHup+LtpLGh....pcDlca.CsphDhhslVPhh..psGhlhtt	.............................h.....................spsslVlDVLRAooslssAlssGAp.....pl.hss..t.sh..-.c.Ahthtpp.............pshllsGE..Rsu..h..pl.p.......GFDh.uNSPhphp...................t..ptl.......p..G.+p.llhoTTNG.Tpu.lppst...pu..p....plls.u.uhhNspAlAchltpt.......scs..............lhllsuG..p..c.........G..........p...........h...........ul...............EDhlsAGhlhptLtpptt..............................hsDtuhsAhthapp...............ttshh.p.hlp..p.uspupcLhp.h.Gh........pcDlph..Cs.ph.chhshVPhh..ptt....th......................................................	0	95	178	222
+4	PF03171	2OG-FeII_Oxy		2OG-Fe(II) oxygenase superfamily	Aravind L	anon	Aravind L	Domain	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].  This family includes the C-terminal of prolyl 4-hydroxylase  alpha subunit.  The holoenzyme has the activity EC:1.14.11.2  catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2.  The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site [3]. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.51	0.72	-3.71	138	7390	2012-10-10 13:59:34	2003-04-07 12:59:11	15	72	1609	66	3461	10006	2827	101.90	28	28.36	CHANGED	sspthplspYs...................thshuhssHsDs...................shlTllhp...........psuGLplhpps.....................thhsssshss..uhllshG-.h.hhossthpushH+lhssp...............tpsRhShshFhps	..................................................................s...hpl.tYP.h.........................................psphshG.h...s.s.....Ho.Dh........................................................shl.TlLhp.......................................sps.uGLQ..l..hpps.............................................................pWls.l.s.s.h.s......s.....u.......hllN.l.G.......Dh..h.....p............h...h.......o.....N.....u.....t..h......c......S....s...h...HRVhsst....................................ttsRh.SlshFhp........................................................	0	752	2020	2858
+5	PF01073	3Beta_HSD		3-beta hydroxysteroid dehydrogenase/isomerase family	Finn RD, Bateman A	anon	Pfam-B_504 (release 3.0)	Family	The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene  isomerase (3 beta-HSD) catalyses the oxidation and isomerisation  of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene  steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.68	0.70	-5.70	12	1802	2012-10-10 17:06:42	2003-04-07 12:59:11	14	22	886	0	831	37083	19903	231.50	24	68.31	CHANGED	lVTGGuGFlGppIlphLlptc..ltElRlhD......hthssph.p.chtphpst....hlpGDlpDtpplcpAhpGsslVIHTAullDlhG.....hhpppplhcVNlpGTpsll-AChpsuVphhlYTSShpVlGPN.hucslhsGcEppsapss..apcsYspSKthAEchVLtANG..h+sGu.phhTCALRP.hIaGcGsphlhstl.pshcps.hhhthuptpsh.s.VYVsNlAWuHlLAA+sLpss......tstltGphYalsDsoPpppYt-hshplh+shGhchss.h....hPh	.......................................................................................hVTGus..G...F..l...G.......t..p...l..l.......p..t.L.....l...p......p......s.............................h..........p....l......p.....s.....h....c.......................................h..t........t..............t................................................t..........t..h..t.....................hh.p...u...D.......l.......p.........s...............p.........t.......l.........t...........p..............A..........h...............p...............s...............s...............c...........s.............V.......h.......H.......s..........A...........u.............s...........h...h.s............................s...t.....p...........h.......h....p...s.....N.....l.......p....G.......T.....p..s...l.....l........c..............A.........s............t............p...............s..............s................V..............p.............p.......l..........V.........a........T...S...o......h..........s......s............l...........h.............s..................................................t...........p...........s............l.........h..............s.........s................s...............E.............p..........h........s........h................................h.........s..........h........Y........s.....p......o...K....h....h........A..E.......p....h....l........h.........t.........t.........s.....t.............................................................t...........................h....h.....o..s..s.....l...R........P...h........h..I........a..........G.......................s...........p...........p........................h........h..........s..........t............h.......h........p........h..........h.......p.........t............t........................h..........h.......h.......h.......s.........................p............................h......s..........h.....s....a........l...............t......N...l..s........h......H...l..........h.........A....h..........p....t......h...............................................G.....p.................a........h.....s.........t.................h..............................h........................................................................................................................................................................................................	0	251	444	652
+6	PF04419	4F5		4F5 protein family	Bateman A, Wood V	anon	Wood V	Family	Members of this family are short proteins that are rich in aspartate, glutamate, lysine and arginine. Although the function of these proteins is unknown, they are found to be ubiquitously expressed [1].	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  --amino -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-7.95	0.72	-3.22	40	536	2012-10-03 11:22:52	2003-04-07 12:59:11	9	10	268	1	333	500	2	37.30	34	47.06	CHANGED	MuRGsQ+ptsRc+stKKptt.t......spsspsphpssp+t..p	.....MuRGsQ+chuRpKNtKKpsp.t......t+ptp-thsssp+t..p..............................	0	100	162	256
+7	PF03061	4HBT		Thioesterase superfamily	Bateman A	anon	Pfam-B_2758 (release 6.4)	Domain	This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyses the final step in the  biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA  thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyse the hydrolysis of other  long chain fatty acyl-CoA thioesters.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.14	0.72	-3.85	140	18406	2012-10-02 20:54:35	2003-04-07 12:59:11	17	57	4420	294	5240	15763	6423	79.30	17	47.56	CHANGED	hGhlaGGsh....hshh-pusshhhtphstt..............hsssshphslsahcs.sphup.hlpspuplhchG+sshhhphclhspssthhs	.................................................GhlaGGhh......h.s.h.h.-.....p.ss.u....h...s...s.t..phstt.................................................tsss.shph........s.lsa..hc...s..s..p..h..........u........p...h.....l.....ps......pu.....p.....l..h......c..h.....G..p..p.sh..hhphclhsppt....h..........................................	1	1455	3083	4266
+8	PF02872	5_nucleotid_C	5_nucleotidaseC; 	5'-nucleotidase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1318 (release 3.0)	Domain	\N	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.11	0.71	-4.25	119	7487	2009-01-15 18:05:59	2003-04-07 12:59:11	13	118	3115	27	1573	5671	648	166.60	21	29.23	CHANGED	slu.......psth.......................t.sh....tp-ss....luslls-uh................tttsss...............c.............lulhss.G.sl........Rs..s........................tG.s...lTht-lh.slhPFs.Np........lhshplsGp.plpphLE...........................tsssthh............phu.........G.lch.ph.Dhsps.................upRlssl..................sup....sl..-sspp..Yplssss.......a.hs....sGucs..a..h......htp	...............................................................................................th........htpss.....hspllssA......................tth.s.ps........................s...................luhh...ss..G..sl..........................Rs..sh..............................tG..s........lThp...slh..sl....hP....as...Ns..............l.ssh.c.loGp.p.l.+..ch.LE..........................................psthh...................................................plh.......G..lpa...p.h....chs.ps.............................................up.R..ltsl.................................................pGc.................sl......-....s..s...pp....Yplusss.............a..hu...........s.G.Gst...a......h...................................................	0	507	918	1282
+9	PF00003	7tm_3		7 transmembrane sweet-taste receptor of 3 GCPR	Sonnhammer ELL	anon	Prosite	Family	This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G Pfam:PF07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor Pfam:PF01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness [1].	25.80	25.80	25.80	26.30	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.91	0.70	-5.02	109	4297	2009-09-14 23:22:24	2003-04-07 12:59:11	17	59	213	0	2615	3557	7	227.40	29	32.05	CHANGED	hGhhh.slhlh...........slFhpappTPlV+usst.pLsallLhulhlsahsshhal.ucPs................shs.........Chl+phhhulsFslshSslLsKohp.lhh..........hFc..tst..stt..hhh......................sttphhhlhhhshl.Q..lllsslWls..hsPP..................................ht.......sht..tptp.llltC.........p..s.sshshh.............hhLuYhshLhllshhhAa........................hsRclP...csFNEAKaIsFoMhlhshlWlsFlP.hahss......pu.p.....................................apssl.shullhSuhuhLhslFhPKsalI	..............................................................................................hhhh..shhlh...........hlFl.....p.a..p..s.T...Pl.V+...Asst...pLsallLhulhls.ahs.........s.hh...a.l....u.c.P.s.......................................hs........................C......h.lRph...h.hGlsFslsh..S.....slLsKThp..lhh.................................................h.Fc.....tsp..s.tp....hhp.............................................stt.hhl...lh.hhshl.Q...............ll....lsshWls.......hsPP.......h.............................................................pt............shp....sp.tp....ll...l.....p...C..................p...p....s.oshuh..h....................................ssL.G..Y.h.slLh.l.h.s.hhhAa........................hsRplP...-sF.NEAK..a..I.sFo..M...............hs..h..s....h.l..W....l.sF..l...P...h...ah.s.o...pu.p.....................................hh.s..s..s.h...hu..ll.hSu..h.sh.Lss...lFhPKsall.........................................................................	0	448	660	1746
+11	PF01661	Macro	DUF27;A1pp; 	Macro domain	Bateman A, Mistry J, Wood V	anon	Pfam-B_434 (release 4.1)	Domain	This domain is an ADP-ribose binding module.  It is found in a number of otherwise unrelated proteins.  It is found at the C-terminus of the macro-H2A histone protein Swiss:Q02874. This domain is found in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alphaviruses Swiss:P03317. This domain is also found on its own in a family of proteins from bacteria Swiss:P75918, archaebacteria Swiss:O59182 and eukaryotes Swiss:Q17432.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.40	0.71	-4.19	124	5297	2012-10-02 00:07:53	2003-04-07 12:59:11	16	119	2806	93	1542	4535	236	112.30	29	10.96	CHANGED	VNAANssLhs.....GGG.VsuAI++tuG.spltpts.pph......tt......stsGpAhlTsuhpLs......s+aVIHs..VG..Phap.....spppptchLtssYcssLpl........s..pcpslc.....................olAhPsISoGlaGaPh-cusplh	..........................................................VNAANsp.h.h.t.........G.uG..V.s..sAI.........pct..u..G..sp.l..t..p.t.s....pp..h............s...........................h.s.Gp...A..h.l..T...p...u..h..s.Ls...............s+hlI..Hs..VG...Ph.hp...................spppptphL...ts..sY...cssLph..............s..pp.p.s.hp...................................................................olAh.....P.s.I.SoGl..a.uhPhppusph.....................................................................................................................	0	543	862	1216
+12	PF02177	APP_N	A4_EXTRA;	Amyloid A4 N-terminal heparin-binding	SMART	anon	Alignment kindly provided by SMART	Domain	This N-terminal domain of APP, amyloid precursor protein, is the heparin-binding domain of the protein. this region is also responsible for stimulation of neurite outgrowth. The structure reveals both a highly charged basic surface that may interact with glycosaminoglycans in the brain and an abutting hydrophobic surface that is proposed to play an important functional role such as in dimerisation or ligand-binding. Structural similarities with cysteine-rich growth factors, taken together with its known growth-promoting properties, suggest the APP N-terminal domain could function as a growth factor in vivo [1].	22.10	21.60	22.10	31.90	19.70	21.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.61	0.72	-4.10	15	356	2009-01-15 18:05:59	2003-04-07 12:59:11	11	16	88	12	114	317	3	98.20	60	14.97	CHANGED	a-P.........pVAhhCG+hshahs...hpsGpWhsDssst...tsChpscp.-ILcYC+KlYPchsITNlVEuu.p.VpIssWCchsp...spC+s....sHhVpPYRCLsGcFhS-ALLVP-	............A.EPQlAMFC.G+LN....MHhN...........lQsGKWEsDPoGT...KoCltoKE.tlLQ.YCQE.hY..PELQITNVVEAN....QP..VoIpNWC++u+....KpCKs.....HhVlPa+CLVGEFVSDALLVP-...............................	0	20	28	61
+13	PF00962	A_deaminase		Adenosine/AMP deaminase	Bateman A	anon	Sarah Teichmann	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.85	0.70	-5.52	15	4245	2012-10-03 00:45:34	2003-04-07 12:59:11	17	22	2418	67	1678	3809	1081	319.30	23	76.53	CHANGED	sl.Ks-hHlHtsushs.cpLLchh+pphht..stssh.p.tphlphtps.csLphhhhshslsshsl+.t........................................................................................h.hhpssRhhsh.ptcchhtstsphlEshapPhhps..........shssp.hsthclhpthlsGhDps-cEst..hss+hhhsch.p.....sppaspph...scshshYh.h..hhsshslhs................phppptthsslhhpsHuGEsushpplhsAhhh....htuccIuHGltltccPhL.thht.p...........QIslphsPlSNssLthhtshccpPlhpahccGlsVSLuTDDPhhFphT...LhcEYslAspsa...thop..s-hsclA+NSlhtSuhscctKpchLuc	........................................................................................................................................................................................h.t.s-lHhH....lsGslp....phl...hc.l..sp....p..t..t...........h.....t..............................................h.........p..........h.......h....h.....p.........h....h.....t....t...........t.......s....L..............p...a........h....p..h..h..s..h.s.h.tslt..............................................................................................................................................p.ps.hp.t.hs.h.t....h.h.p.c.h....t.....p...s...s.ltahElh...a.s.P.....hhs....................................pts.........h....s...h...t......t......s...l..p...s....l.......h.p..u..h...c......p....u.......p...c...p.hs..............lps.p.h.....l.....h.s..h...Rp..............stph...s...p....ph................hp...hh....h...t...a....t....p............hlsul.sl..s..u.s.E...s....h.sst................ahp.h..h..p..p...s....p.p.t.......s..h..t..hssHA.......G..E........s........s........s........s........p........p...l..h..p...Alth.........................hts.c..R..I.uH....Gl.....p.....h......h.....c..........c.......................t..........L.....h......p..h...l...h..p..p........................................pIs..l...Eh....CPh.....S..Nh.p............h...........t..h...............h..............t....s.......h.............t....p........H........P....l.....t.......p.....h...........h.........p.........t.G.........l.....................s........o...lsoD.DPsh........sss.....................l.cEat.hs.t.....pth....shs.........pp...ht.p.h................s.h.Nul..phua.hst..p.p.Kpthh.........................................................................................................	0	516	944	1371
+14	PF01490	Aa_trans		Transmembrane amino acid transporter protein	Bashton M, Bateman A	anon	Pfam-B_419 (release 4.0)	Family	This transmembrane region is found in many amino acid transporters  including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane  domains Swiss:P34579 [1]. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance Swiss:P38680. Other members of this family include proline transporters and amino acid permeases.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.16	0.70	-5.99	24	6390	2012-10-03 01:44:59	2003-04-07 12:59:11	13	58	501	0	4195	7221	166	337.70	15	78.72	CHANGED	pssoshpushpllsuhlGsGlLuLPaA.hpphGhlsGlhhllhhuhlohaohhlLspshph.........tppttoYt-ls...........tphhGsth.hhlhshs.hlp.lGhsluYhlhsupsl.slhpshh....tt.......h.h..ppshahhlhshlhhsLo.hlsshstLuhhSlluslhhhh.....................hshlhhhhhshshhsshshshhsh........thphhphhhulGslsFAasspshlhsIpssh+s.Ppp........cshhhuhhhsslhahhhGhhGYhsFGsssts..sllhshs.p......hhshsplhlsltllhuhsl.hhPlhphl-phlh...................................................................................s.hps.hhthh...chhhRshlVlhohhlA.lhhPhhstllullGuhushsloalhPshhahphhtsphhshphhhh...hthhhhhhulhhhhhushshlh	........................................................................................................................................................................t...t...shh.hhp..........sh.....l..Gs.G.l...L.u..h...P.....h...u....h.t..................p.........h......G.....h.....h.................u..h.....h....h..h..h.........h...h...u..h.hs..h....a.s....h.h.l.l....h.....p.s.h....................................t....h..sa...t..phs.......................................................thh.h..G.....hh....th....hh.t....h..h.h........h...h........h.......s.h..............sh.s....ah....lh....h.u.p..h....t...h..h..t.....t..........................................................h...p...h....h....h..h.....h...h...h..h..h.h...h...h...s....h.......s.....h......h.....t.....p...h...p..........l....t..h....h.u..h....h.uhh.hhh.h...........................................................hhh...h..h..h...h..h....................h......................t.h...........................................t.............t....h......h.....s....h....s...h....h...h.....a........u......a.............................s...p.......................h...h...l.................s....p....h...............p...............p....s......pp..........................ts.......h....h......h..s.....hh.......h...s..h.h.h.....a.....h..h...........h.........u.h...h...u.............Y............h....t.....a.........G......s..........t......s....t...s...............s.....l.hh.s..h.s..............................h.h.h...s.......h....h...h....h...h....t.h...h.h...s.....h....s........l.......h....h.........s..h...h..t...h...l...t.hhh.......................................................................................................................................................................................................................................t.........h.......h.h...........hh.h.h..p..h...h..h..h....h..h...s............hh...lu....h....h...h..P.........h..s...........l....h...........u...h..h..............G.uh...h..ss................hsh...h.......hP..s.h..h...hh.......h...........h..h......................t..........................................................h.............................................................h..h.h..h..h.h..s.hh....h........h..............................................................................................................................................................................................	2	1380	2401	3501
+15	PF00004	AAA		ATPase family associated with various cellular activities (AAA)	Sonnhammer ELL	anon	Prosite	Family	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.75	0.71	-3.95	207	52090	2012-10-05 12:31:07	2003-04-07 12:59:11	24	426	6164	264	20937	92205	29927	130.80	25	20.90	CHANGED	lLLhGPPGsGKThlA+ulAsp...............h.............s....hs.................a.hplsusplh.t................ahGtutppl+plapp.A....cpts........s.sllFlDElDulssp+................t..tppshspLLsthDshpst..........................s.lhlluATNc..s-tl-sALh.h.uRh-phlhhsh	....................................................................................................................................hlLhGP.P..G....s.........G....K.........T....h........l....A....c..........u...l...A...pp...........................h..............................s................tp.......................................................................h...h......p...l....s...s...u....s....h.....h.....pt..............................................................................................................................................................a..h..G......p....h....t....p......c......l......+......p......l.....h..cp....s..........cpps...............................sll...F...l.....D...E....l....c...s...ls.sst.......................................tt.t....t.t...p...s....h.....s....t...L....l......s..t......h...-...s.h.p........................................................................................h...h...h..l.....u...A.....T....st.............p..........l.....s........s.lh.........tR.hph......h...................................................................................................................................................................	0	6957	12667	17600
+16	PF00696	AA_kinase	aakinase; 	Amino acid kinase family	Bateman A, Birney E, Griffiths-Jones SR	anon	Pfam-B_100 (release 2.1)	Family	This family includes kinases that phosphorylate a variety of amino acid substrates, as well as uridylate kinase and carbamate kinase. This family includes: Aspartokinase EC:2.7.2.4, Swiss:P00561. Acetylglutamate kinase EC:2.7.2.8, Swiss:Q07905. Glutamate 5-kinase EC:2.7.2.11, Swiss:P07005. Uridylate kinase EC:2.7.4.-, Swiss:P29464. Carbamate kinase EC:2.7.2.2, Swiss:O96432.	24.90	24.90	25.00	24.90	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.76	0.70	-4.83	135	25691	2009-01-15 18:05:59	2003-04-07 12:59:11	23	74	5328	286	5789	16900	9693	240.60	20	64.39	CHANGED	phh..V.lKlGGssls.st...........t.lp.plspplt......t.......................hhpt........shcl.llVsu...uG.....s....hssthhpt.............t..........................t.h..ptt.................tltp....................httlhst.hpphss.thhshhhps......tsh.shth....................................tptlpphlp..p..s.hlsllsuhh.....ss....ps....th..................sthssDtsAshlAttlpA...c..lhhh..oDVsGlastpP.....su.phlsplshp-htphh......................psGhtshh.tuhpss.pp..s..shplhlhs	.....................................................................................................hlVlKhGGsuls.st......................................p.lp.p.ls...p.p.lt.......p...........................................ht.pt.....................................Gh..cl..llV....pu.....uG........s.....hssthhtt..........................................................................................................t..h.h.h.pt.t.....t..........................................................thtp..................................................hh.s..hlsth.....h......p.t...h...s...s.......hs....h.sh..h.hpp................ts.h...s.t.t.h...hth..........................................t.....hs.tp.tlp.p.h.Lc......p.......s.tls..l.h.suh........ss...............ps...th....................................shhssDpsAu.hlA...t.....t..l....p...A.............D...hlllh........T-V..-.G..l....as.s.s...Pth............s....s....u...p........h...l...s....p..l..s..h..p..-..hhchh..........................................................tG.ht.sh.hts....Ahphs.pp....t.s..h.shhlh..............................................................................	0	1858	3683	4867
+17	PF03109	ABC1		ABC1 family	Bateman A	anon	Pfam-B_339 (release 6.5)	Family	This family includes ABC1 from yeast [1] and AarF from E. coli [2]. These proteins have a nuclear or mitochondrial  subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex [1] and E. coli AarF is required for ubiquinone production [2]. It has been  suggested that members of the ABC1 family are novel chaperonins [1]. These proteins are unrelated to the ABC transporter proteins.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.40	0.71	-4.13	32	5521	2012-10-02 22:05:25	2003-04-07 12:59:11	11	49	2872	0	2412	4867	2734	116.90	31	21.56	CHANGED	ppLG.pshcchFppF-ppPlAuASluQVH+ApLps........GppVAVKVQ+PslppphptDlthhphlsphhpth..t........clttllc-hpcpLhtElDahpEApssc+htcthpch.....shlplPpla	.................................................t.thG.tsh.p.p.hF..s..pF-...t...p.P..lAuASIu......Q..............V..HpAp.L+s.....................................Gc..c....V.sVKVp..+Psltp.................hlpt.Dlpl....l......p...hl.u.......p.h....h....p...t....h.h.st...................hhc.hp...pll.......cEhp..........c.......plh.........pE...........lDhhpEAtNs.pphp...c..p..hp.sp............s.hl..hlPcl........................................................	0	828	1543	2052
+18	PF01842	ACT		ACT domain	Bateman A	anon	Bateman A	Domain	This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.  The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine [1]. Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585	20.80	20.20	20.80	20.20	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.83	0.72	-4.43	180	20885	2012-10-02 00:29:19	2003-04-07 12:59:11	20	130	4518	161	5944	23355	10616	64.10	16	16.98	CHANGED	thlt...l.tst.-c.sGlluclhshlucpslNlpplpttsstt...........thhhhhhhssppshpphhcplcphhs	......................h..l.h..h...Dc.PGllucls.shlu.c..p..slsls.ph.p...psstp......................hthhhhhh...hspt.t.tthht.h.....t.............................................	0	1838	3898	5060
+19	PF04083	Abhydro_lipase	abhydro_lipase; 	Partial alpha/beta-hydrolase lipase region	Wood V, Finn R	anon	Pfam-B_267 (release 7.3);	Family	This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.17	0.72	-4.61	82	1362	2012-10-03 11:45:05	2003-04-07 12:59:11	11	14	288	4	980	1460	9	63.00	36	14.19	CHANGED	sscllppaGYssEpHpVpTcDGYlLslaRIstsp...........................................t.tspPs...VhL.HGLlsSSssWlhss	........................phlptaGYssEpHp.VpTcDGYlLslaRIPpsp.......................................................................................................ttt.ttt+..sVhLp..HGLlssSssWlhp.h...........................................................................	0	284	440	775
+20	PF00583	Acetyltransf_1	Acetyltransf; 	Acetyltransferase (GNAT) family	Bateman A	anon	MRC-LMB Genome group	Family	This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.44	0.72	-3.95	241	50804	2012-10-02 22:59:21	2003-04-07 12:59:11	19	363	5227	314	15580	72453	11235	83.90	18	39.27	CHANGED	hptsspllGhsththhtp................................................ttstltslhVp......ssa+spG.lGptLlpthhchstp..hs.......hpplthts.tts.Ntt...uhphYp.+hGFp	......................................................................................................h...tspllG...h....h..h..h...hh..p.............................................................................ttht.l...t....p..l..h..V.p...................s...p...h...+........s..p..........G....l......G....p......t....L....l........p.....t......h....h.....p..h....upp.....ts..............................h.p..p..l....h....L..t.s.....tt.......p....st............uh..t.hY.p..chGa...................................................	1	4938	9501	12964
+21	PF01648	ACPS		4'-phosphopantetheinyl transferase superfamily	Bateman A	anon	Pfam-B_1679 (release 4.1) & Pfam-B_3672 (Release 7.5)	Family	Members of this family transfers the 4'-phosphopantetheine (4'-PP) moiety from coenzyme A (CoA) to the invariant serine of Pfam:PF00550. This post-translational modification renders holo-ACP capable of acyl group activation via thioesterification of the cysteamine thiol of 4'-PP [1]. This superfamily consists of two subtypes: The ACPS type such as Swiss:P24224 and the Sfp type such as Swiss:P39135. The structure of the Sfp type is known [3], which shows the active site accommodates a magnesium ion. The most highly conserved regions of the alignment are involved in binding the magnesium ion.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.84	0.71	-4.27	154	7983	2009-01-15 18:05:59	2003-04-07 12:59:11	15	48	4744	99	1916	5342	1894	110.90	21	48.33	CHANGED	slGlDlEph.....pt................................thtp..lhpph.h...sspEhphltphss....................................thhhthWohKEAhhKuhs....t..................h..hsthphphtss.................................................h..htttttphpht...hphttptthssshs	.....................................................................lGlDltcl......pph..............................ppspp...h..h...c+l...h...os.s.E.h.phhp.shpt...........................................................................h.p.hh.s.thausK.EAhhKAhG......pG.......................................th..hshpp.l.plhps...............................................t..................................................................................................................................................................................	0	622	1194	1612
+22	PF01064	Activin_recp		Activin types I and II receptor domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_338 (release 3.0)	Domain	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich  ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.21	0.72	-11.34	0.72	-3.34	26	942	2012-10-03 01:43:02	2003-04-07 12:59:11	18	17	116	67	464	892	0	83.70	25	16.38	CHANGED	lpCh.Css..........Cs..pss.....ppCps...................suhCasthphspst...hphhpp....GChshppts......hhCps..................sss...spshtCCp.sDaCNcshp..h	........................................................Ch.Cp.......C....pss.........tpCps...................sstCasshpp...sss........hphhpp..........GChstt.tps.................hpCts.............................psps.........spsh.h..C.Cs...s-hCNpph....h.................................................	0	82	118	270
+23	PF00441	Acyl-CoA_dh_1	Acyl-CoA_dh;	Acyl-CoA dehydrogenase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.47	0.71	-4.11	58	26994	2012-10-01 23:33:27	2003-04-07 12:59:11	19	118	3319	208	9422	25135	11877	150.80	24	33.41	CHANGED	spGathshps.lshpRhslustshGhsppsl-pshpascpR..psFG.p.lhshpslpppLAchtsclcus.+hhshpsup...thcpspss........tttsuh.sKhhuschstclsppAhplhGuhGh.......h.pchs..lp+haR-s+shpIht.GosEl.tttllu+phh	..........................................................................................................................spGhthhhp...t..LshsR..l...s........l....u....s....t.....u....l...G..........h....u........p..t......u.....h..c..t.....s.....h..p.....Y...u...p..p....R....................p....p...........F............G......p.............s...............l......s........p......h......p...s..........l..............p......p...p........L.......A.......c...h...t.....s...p..l..p....s.......u.....+.......h.......h.......s......h....p.s.A.t..................th...-...p...upss................................shtsu.h....s........K........h.....h...s....s.....c...t..............u...h........p....s....s..s...p...A.l.Q......l.....h...........G....G.h..Ga..............................h..p-hs..........lt+..h...h.....R....-....s.......+....l....h...p...lhp....G.ospl..p.t...hluc...h................................................................	0	2614	5667	7871
+24	PF01757	Acyl_transf_3	DUF33;	Acyltransferase family	Bashton M, Bateman A	anon	Pfam-B_708 (release 4.2)	Family	This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterised C. elegans proteins and it is approximately 300 amino acids long.	31.00	31.00	31.00	31.00	30.90	30.90	hmmbuild  -o /dev/null --hand HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.29	0.70	-5.61	111	12610	2012-10-02 17:00:17	2003-04-07 12:59:11	17	41	3761	0	3737	10989	1698	328.50	15	74.75	CHANGED	hhtlD.....hlRsluhlhllh.hHshh...hhhh.shhh......................................hhsthslslFhhlS..Gahh...................................hpttshhphhhcRhh+lh....lshlhhshlhhhhthhhhththhthhhhhhhh.............................................................................................................................................hhshhW........alhsh......hhhhllhshh...............hhhhpphtthhhhhhhhhhhhhhhhhhhhhh...................hth..hhh.............................hhhahhGhhhsphttphptthh..............hhhhhhhhshhhhhhhhhhhhhht................................h..hhthhhhhhshhhhhhhshhhtpht.....thh..............hlthlu.phShslYlhH...........hhlhhhhtthhhhh.................................hhhhhhhhhhslhlsh....lhhh	...................................................................h...l-slRuluhlhVlh...hH....hhh...............hh.h.......................................................................................................huh..h..u...V.s..l..FFhl.S..Galhh.................................................................t.tp..h.....s.h..t..p....a...h..h.......+.....Rh.hR.lh................hsh.l.h...h...h.........h..l.....h.........h.........h........h......h.........h......h........h.....h......t......h.....h....h...h....t.....h..t...h.....h.hh.h..............................................................................................................................................................................................................t....h..h..h..p.....h...W.................hLss...........hhha..ll...h..sll............................................hhh.h.....t......p........h....t.......t.........h.........h......h......h.........h......h.......h.........h...h....h......h.....h....h.....s....h...h...h...h...h...h..h..h................................................h....................h..h..........................................................hhha..hhG....h........h......h....s....h....h....h...h...t....h...t...t..t...h........................................................................h.h.h..h.h....h..h..h.....h......h....h.s..h..h..h..h.h.h..h.h.hhhh.....................................................................h..h.....h....h...h....h......h....h.....h.....h..h....s..h....h....h...h...h....h...h.h..h...t.h....p..ht.................hh........................................h.ht.hlu..p.h.S..a.u....l....Y....L..h..H................................h..l...h...h..h..h.t..t..h..h.hth...................................................................hhh.hh.hh.h.h.h.s.hhh.sh....hh..................................................................................................................................................	0	1161	2171	3133
+25	PF00928	Adap_comp_sub		Adaptor complexes medium subunit family	Finn RD, Bateman A, Coggill P	anon	Pfam-B_1007 (release 3.0)	Family	This family also contains members which are coatomer subunits.	20.80	20.80	20.90	20.90	19.80	20.70	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.86	0.70	-5.29	46	2208	2012-10-02 01:13:52	2003-04-07 12:59:11	16	30	497	31	1352	2129	25	258.90	25	54.82	CHANGED	hsh+sss.hp....appNElalDllEc....l.ss.lhsp.sGp...llpu-.lpGplphpshLsG.hPplplulsc.h.............................................sh.l--hpFHtCVphsp.a.cp....................p+hlsFlPPDG..cFpL......hpY...+l.......................................................spp....hthPhpl.hsphp........................................................p.tst.schchhlphctp......htp...sspslhlplPl....Pps......................................ssssshps.stG....pspapsppp...hLhWsI....tclss......p...hp......................................................u.plphssthp...................phss............................lslpFplshhssSul...........................pVchlcl..h..t......pshpsh+hV+YhTpus.paplRh	................................................................................................................................hp.t.s.hp....apps.ElalDllEp....................l.s.........h.l..............hst.....s.....G..p....................llpuc....ltGpl....phps.h..Lo...G...hP..-...lp..lulsst................................................................................................................ttshtl-D..spF..H...CV..chsc..F...-s....................................................c+hl......uF......l.......P.....P.....D......G.....pFp......L...........hp........Y....Rh.........................................................................................................................................................................ssp.........h.l.h.pl..ps.hp.......................................................p....up..s+h-h.hl...p.hctp..........................htp.....hspsV.lpl...P.h....Pps............................................................................ssssp..hps.....s.G................php.aps.ppp....slhWpI.....tphss..........tp.....shp.......................................................................................................u.ph..ph..s.s..t...st.t..........................th.s.........................................................................................................lslpFp.....l....s......h..s...sS.Gl................pV..chlpl....p................tthpsh.h.V+a.spst...h.......................................................................................................	0	456	720	1076
+26	PF00107	ADH_zinc_N	adh_zinc; 	Zinc-binding dehydrogenase	Sonnhammer ELL	anon	Prosite	Family	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.35	0.71	-4.60	108	42002	2012-10-10 17:06:42	2003-04-07 12:59:11	21	474	5352	463	12979	36140	9081	125.70	20	28.57	CHANGED	ulGhhulphA+shG.......spllssstspp+hchAcphG...Astslsspptt......................hhppltchssu.........GsDsll-ssG.ssshppulphlphsGplshlGhss............tshshshhtlhhpphslhGshhss........pphtphlphlhp	.......................................................................ulGhhul.p.h....A.+..t.hG...........scV.l....u....s........s....t...........s.........s......p.........+........h.........c.......h.........A.....c......p...........h.....G..........A......s........p......s....l....s......ppts.................................................hhptl..t..c..h.sss.......................G.s..D...h..s..l...-.....s.......s.....G..........................s............t...........s............h.....p............t.......s.....l.....p...........h.....l........p................s........G.........p......l......s.h.l.G.hss........................t..h...h...s.....h..................h....h........h..p...t..h.p..l.h.....G..h..hht............t...........t...................................................................................	0	3503	7483	10666
+27	PF02682	AHS1	DUF213; 	Allophanate hydrolase subunit 1	Mian N, Bateman A	anon	COG2049	Family	This family is the first subunit of allophanate hydrolase.	20.40	20.40	20.40	21.10	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.08	0.71	-4.85	158	3092	2012-10-02 15:38:38	2003-04-07 12:59:11	11	20	2321	14	753	2183	1289	203.30	32	52.43	CHANGED	h..p.lpshG......-pulllphs.pt.hs.......shtppl....hsltptlppt.......hsulh.-llPuhsolhlpa-.shth............sht..plt....stl....pph.hpp...ttspttsst..............p...........lclPVtYssphG......................DLtpVAchsGLo.hc-VlphHosspYpVhhlG.FtPGFsYLuulstp...L.t.sPRpssPRtplPuGSVuIAGpQoulYPhsSPGGWplIG+Tsh..tlF.Ds.pp.psP...sll	...............................................................chh.hG-pulllc....ht........lsh..........shp.tcl....hsltptLppt................hssll...-l.lPuhs....slhlhac..stt.l..............................shp...slh..ptL..............pph..hpp.............tpshpsss.............................................+h...............lcIPVhYs..s.th...G..........................DLp.VAchsG.Lo...hcpVlchHoss...pY....hVhhlG.FhPGFP....YLsulspp..........L..t.sPRpspPRhtlPuGSVGIuGspoGlYP.hs.oPGGWQlIG+T.s..l...plFcs.pc.p..h.......................	0	200	423	624
+28	PF03915	AIP3		Actin interacting protein 3	Wood V, Griffiths-Jones SR	anon	Pfam-B_38461 (release 7.2)	Family	\N	24.50	24.50	24.80	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.37	0.70	-5.57	18	245	2009-09-10 22:05:34	2003-04-07 12:59:11	8	6	183	3	166	277	0	303.00	27	37.23	CHANGED	FL+lssKsKKshlsh...slo.hspLRLLFlEKFAYSPGss..sFP-IYIpDPpouVpYELE-..Lp.DlK-GolLsLphcp..................c.ssshssLpc.hlcsl+pplscppssl..................hpclpsh.tsssh.hsp.ssuss.....sttspppssstt.ttps..................hpElpslc+-Lull+QhasstpsslpsolsslhpKlssh+s.sulsss.....ssSsRuYh-pupscLu--SDpLls+VDDLQDllEsLRKDVApRGVRPsc+QL-slsK-lppApc-LpcMppaIspEKPhWKKIWEsEL-+VCEEQQFLsLQEDLshDLp-DLcKApETFsLVEQsocEQtKssups................+s+sl..lslscPG.ohpph+DtVLsEVpuLpPsHESRlEAIERAEKLRp+E+chp+sscFpcELusFVEcuKLKKSGGlEElERhR+tKD-	.....................................................................................FLQhtscsK+hhlsp........tlo.hsplphh....FlcpF....shp..t.p....chP..p..IYIpDs..ps.lhaELED......lp.-l+D+olLhL..c................................................................................................................................................................................................................................................tphptlp.-lt.h+p......h.pt..tthtt.htshh.p.h.t.t..htt....s..t..............ttt.hhpttpp.htt.s.tl.tc...lp-LpshlEth+tD....VhpRtsps..ptlcth...ltthptpltphp.hh.t.p..hpphhptEhp.l..sptpp.hp....c.h....th.t.htth.thh..ht...h..................................................................................................................................................................................................	0	57	95	141
+29	PF00842	Ala_racemase_C	Ala_racemase; 	Alanine racemase, C-terminal domain	Bateman A, Finn RD	anon	Pfam-B_1496 (release 2.1)	Domain	\N	25.00	25.00	26.50	25.50	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.61	0.71	-4.73	121	5638	2009-01-15 18:05:59	2003-04-07 12:59:11	16	16	4223	90	1060	3928	1372	125.90	36	32.58	CHANGED	lhs.Lcucllpl+pl.psGps..lGYGtsapspcss.plAslslGYADG..hs.Rthus.ps................l....hlsGpps..Pll....GRlsMDhhhlDlo...........ph...ssp.G........-pVhlhG.tp......hss--lActssTIsYEllsplut.Rl.Rhah	......................shoLpoplltV+pl.p.s..G.-..s..VGYGs.sap..u..pc.cp..pluslslGYAD..G..as.Rph..ss..ts...........................V.......ll.......s....G....p....cs....sll....GRVsMD.hhVDls.......................p.sphG......sp.VhLaG..pp........................lsl--lAph.s.s.TI.sYEl.l.stl.sp..RlsRha.h..........................	0	358	686	893
+30	PF01168	Ala_racemase_N	UPF0001;	Alanine racemase, N-terminal domain	Finn RD	anon	Manual	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.87	0.70	-4.79	613	12691	2012-10-03 05:58:16	2003-04-07 12:59:11	15	33	4649	104	2910	10839	5318	218.10	20	66.44	CHANGED	lsLsslppNlpthppts....s..........ss.lhAVlKusuYutuhhpsut.h..t.u.....s..c.....shulsplpEAl........................tLc....ps..............tl.hh..........ppl..hhp.......slhhslsshcth.p.tlsptttt................tpslplhlpl-o.Ghp........RhG.........hs..s........pth.........phhp...tlp...........s.....lplpGlhoHhus.u............-....p.t........tpp.p.hpph....pphhptl........t.....t...............hhshusSushhht.........h......p...hsh.VRsGhslaGh...ps	.................................................................................................................shttlppNlpthppts...ts............ss.lhA..VsK.s.......hsts.h...h.p.hs...h.....................t......t..u.....h.....p.....................t.h..u.....s.p..l.p..Euh........................................................................pLp..psh.................lh....h....h.....................pp....l...........h.hp..........t...sh...h.....h....s...l.s...s.h.chh...p..tlpptt................................t.ps.lp..l..hl..p.....l.....s............s...uhp.................RhG..................lp...s......cch................phhp.......plpp..................h..ss......lp.l.t.Gl..hohhuts........................................-c.p...............htp....p...h....pp.h......................pphh.ptl..............pt..t......................hlS.h.u.sS..ushhht..................p...hhsh...VRhGhslaG.t..............................................................................................	0	960	1857	2470
+31	PF01315	Ald_Xan_dh_C		Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.35	0.72	-3.99	30	5239	2009-09-12 04:57:33	2003-04-07 12:59:11	17	77	1902	114	1766	4735	2068	108.20	30	12.95	CHANGED	TGcAhYsDDlshssst.ahshltSshAHA+IhuIDsspAhshPGVlullTucDlsstspshh....s.hsp.......lhAc-cVphhGpslAhVlAcspttAccAAcLVpl-YEcLs	............................................oGcupYs...-D...h...s....h....s....s....h....h...a..sth.l.pSs.h.A.H.A+......I..t...........u.lDs.st.A..t.......s.hPGVl..s..llT..tp..D...lss...h........t....hssh...........h..tsp........................hh..s.......s...s.......c..V.c....ahGpslA.hVlAcotttAccAsphl..c...l-Y-.L............................................	0	567	1035	1411
+32	PF02738	Ald_Xan_dh_C2		Molybdopterin-binding domain of aldehyde dehydrogenase	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	19.60	19.60	19.70	19.60	19.10	19.50	hmmbuild  -o /dev/null HMM SEED	547	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.43	0.70	-6.19	30	9467	2009-01-15 18:05:59	2003-04-07 12:59:11	13	89	2059	116	3266	9151	5213	368.20	19	64.65	CHANGED	Alc......ppshhsph............hphhppGD...sspuFspADt.......................llcuphphupQpahahETpuulAl.c.p-sclplasSTQsPphspphlApsLGlPtp+lclhspclGGGFG.pcscshshsshsALAAh+htRPV+hhhsRpEchhho.utRHshhhph+lGhsp-G+ltAlchchhssuGshsshu.slh.puhhts....ssYchsslchsuhsstTNhssss.AaR.GaGssQuhauhEshlcclAppLGl-s.ElRchNhh...cts.tsha.spphsshshhp...th-cshppspappRp.......ttlcp.....hshsp.pahc+Gluhsssphshshsss...tusutlplhsDGo...lhlphGus-hGQGhpTphtQlsAcsL.........ulshccIplppss.TspsPpusuTuuSpuoshsGtAltpAscplpc+Lp.htsphht.........shsacch........sssuhsssls.sApuhatss...........s.shphtt...s..spsh.hasaGssssEVElDshTGcscll+s.hlhDsGpslNPtlshGQIcGuhsQGhGhhhhEElhas.ssG.lhspuhhsYcIPshs-lP	......................................................................................................thh.........................................................................................hp.........h................hEs....hs...............t...............t......t..........t.....h.......hh...s.Q.........................t.....h.s...h.....h.....t.....h..................t..................t....l.....h............hG.GuFG.....t..........................................................s...h.....h.....h......s..h...h.....h.........t.....t.......s.....lp.................h...sR..p.h..t....t....................p.h..p......h...u......h..p.......t.......p.......G............l.............u....ht.....h......t........................h.....................t......................h....................................t.......................................................................................................Y......h......t..h...h..t...................h...s............................s..h.....h.R.....u.....u.s.....s.hh.h.E.hhp.h.A..tht......h..ssht.hR.hph......................................................................................................................................................................................................................................................................................................................................................................................................................t.........s.....l..........h...........s..Gp......h..l...sh..p..GpG.h...Thh.t...h..hup.h................................th.s....p..t..l.......h...................s......t..............t...................h.................s............................s.....h........u......S.t.............h.s...h...................s....s........h..t........h..h....h....t.........................................................h........................................................h.......................................................................................................................s.......s.....s......h..s.....l...t.l..s....................s..h...........p..l.p..h.................h.s.h..G.......lNs.h..tQ..............h.Guh.h...u.h.u..h.tt..........h.................................................t..........h.....................................................................................................................................	0	967	1893	2579
+33	PF00248	Aldo_ket_red	aldo_ket_red; 	Aldo/keto reductase family	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.57	0.70	-5.58	61	28932	2009-09-12 09:01:48	2003-04-07 12:59:11	16	110	4596	377	9885	23584	7566	269.00	25	87.49	CHANGED	pluhGshthst.............thspppshph...lctAl.ctGhs.....hlDTAph.........Y...........utuEph.lGc...hLpp.........+cplhlsoKs..................................ht.shstp.....plppslcpSLccLph.-hlD.lhhlHtsssths..........................hp-sh......ptlcchhp....pGpl+tlGlS...shs.hpplpph........tpttht.....hsssQspashh...........tthppplhp..hspp..p.slsll.uauslut...............GhLptt..........................................................................thhphlpplucp.hsh.ohsplulpaslp..............s.....................tsssslsGs..sshpclcpslpsh...ph.pLsppphstlcplht	.........................................................................................................luhGsh.th.........................ths.t.p.p.s.h.ph.......lctAl....-t...G.hp...........................hhD.T.A.ph.........................................Y...........................p.sE...p......h....lGc.....ulpp.................................h.R-c....l....h......l......sTKh..........................................................................................................h.....t..s....h..s.hc...................plh.p.u.l-.p.S.L...c.........+...L..........t.........h....D..........Y.....l..............D....L...a....h....l.H...h.....s..s...s..t..ss...............................................................................hp-..sh...................pAh.p.c.l...hc........................pG...+..l.+.t.........l.....G.....lS.....................Nas...sp.p...lpph.....................................t.ps.tht..................hs.s..s..Q.s.c.hshh................................h..p..p..p...l..ls.............hspp.......p..sl.s...hh..ua.....o......P.Lu.p..........................................................G...hl.t...t....................................................................................................................................................................h...pt.l.p..p.....l..A.....p.....c...h.....s......t...o...s...u........Q........l.....s.....L...t.Wh..l....................................t......................................................................................................t.s.s.ssIs.uu........sp.p..p..l...p..p....N.h.tsh........sh...pLotc-httlpth..t.................................................................................................................................................................................................	0	3142	5960	8241
+34	PF01263	Aldose_epim		Aldose 1-epimerase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.10	21.10	21.20	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-12.04	0.70	-5.31	66	8201	2012-10-02 23:57:29	2003-04-07 12:59:11	15	27	3660	74	1995	6054	1148	286.20	18	90.64	CHANGED	phlslpss.pthpsplhphGAplhShpsss.t...t-llhshsp.....ta.tt........ushlsthAsRl.ttGta.hpGtshplshNs................stpshHGtsps...phWpltphp.........stsphphh..sssc.ps...aPtplpsplsapLsspst...Lplphcupsst....cshshshs.HsYFNls.........hptpplplpu..pphhphss...hs....hshptssh.sh...ppsphlspch............thDpsahhss..........hphshhhhptspshtlchpsspsshhlassshht.................hhhpttuhshpsphhssssspsphs....hhLpsGEpaptphthp	..........................................................................................................t..hplpss...thps..p.l.h.s.h.GAplhu.hphss.....................pcll..h..s..hss..........t..h.tt......................hu..s.h.l.s.hus..Rl..tt........u...t.h...........h............t...G....p....sh.p.l...shsp......................ssp.s.h.HGh..scs........................p.Wp.lhpps............................ptlphs.h.p..................ssp..ts..................a...P...t......sh............plplpap.....L............ss.......s......s................lp.....lp.h..psp...s......s.............psh......shsh..s.Hs......Y.Fs.ls.....................hp.p.pp....lp....l...su.....t.thh..........h...sp...............h....s............t...........h...t.h.t...s....s.....s....h....-h........ppst...l.s.tp.............................................th..Dcs.ahh.t..............................................phthh.h.h..p...........p...p..t....h..t.l..p..h....t....s...s...t.......s..l.......l..a....ss...s.ht.....................................................................hhth..s...h.s.h..ts.p..h..h..s.s.p..s..t.......p.....s.....ths........hhLtss.p..hp.................................................................................................................................................	0	599	1167	1644
+35	PF03155	Alg6_Alg8		ALG6, ALG8 glycosyltransferase family	Mifsud W	anon	Pfam-B_3941 (release 6.5)	Family	N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid  (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one [1]. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147 [2].	25.00	25.00	26.20	26.00	22.80	23.30	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.88	0.70	-5.65	9	764	2012-10-03 03:08:05	2003-04-07 12:59:11	10	16	267	0	527	725	13	353.20	28	86.10	CHANGED	hsslhl+hh..LhPh.tp......sDFEspRpWhtIThsLPlupWYhpuosp....WsLDYPPhhAYapalLuhlupa.h.sschls.hpshGaES.sp..hlF.RhoVIhs-lLhhls.lhhaspsh...th.+..spppphhsuhhlLhpPGLllIDHhHFQYNulhhGlhlhuIsslhpcp.alhuAhhFslulsFKphhLYhAPsaFsaLLtp.Clp.sp....ht...........taspllpLussVlusFslhahPahhh....ppl.QVLpRLFPFsRGLhcshhA.NFWshaNsh.Kltphlsh.................................................plt..lohhhTllu.LPuhlhLahcPp....+hFhhuLshCuhu.FLFuapVHEKuILLslLPhslLhsttst..h.hhhhhsssuhaSLaPLLh+sshhh.phlhhhsa.hh.....hs........................p...thhh..hphlphhalluhhslhhh.phlp.hl...s.spKaP.LhllLsushuslshhhha...lah.h	.....................................................h....hh+hh..l..s...t............sDaEspRpWhtlT.pLPlppW....Y..h.t..........WsLD.YPPhhA............aapahhu...huth....h...ssthht..................p..s.....h.shts..th...hhF.RhoVlhs-hlhhhs......lh.......h.h......h......................................t....................................t........h...............h.h.....llh.suhlllDahHFQ............YNs.h..hGhhlhul..hh...t.............tp..................h....h.....uu.hhFshhlshKph.LYhu.sh.hha.LLtt....sh.............t...........................................................hhphh.tluhhshhshhh.h.hPa.h............................tth.QlhpRlFPh.tRGLhc...shhA.NhWshhsh..h......+hh..hh.....................................................h...hshh..hT.....h.h...h....................shh.....l....h.h......p..........sp...........................th.h.hslh.su...hu....FhFuapVHEKulLls......hlPh...sll..h...t.................................................hh...hhh..huhh...ohhP..LLhps..t.h..h.hhhhhha.hhh......................................................................................................t.....h.h........h..h..h..h......h..h...h......th...h.....hh...............p...h..l..hh.s.hs..th...h........h...............................................................................	0	184	291	438
+36	PF00245	Alk_phosphatase	alk_phosphatase; 	Alkaline phosphatase	Finn RD	anon	Prosite	Domain	\N	19.80	19.80	19.80	19.90	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.42	0.70	-5.79	10	3561	2012-10-03 20:55:17	2003-04-07 12:59:11	15	33	1898	200	1070	2985	602	329.70	28	81.45	CHANGED	AKNVIlhlGDGMGVuolTAARhLKsptcsphs.-h.LuhDchPhsGhu+TYssDpp......VsDSAAoATAahCGVKTspssIGVo............spGs-V..hSVLEtAKcAGKusGlVTTTclsHATPAuhhAHsssRshhussss.....ssthhptG.....ptDIucQLlssh...cIDVlLGGGR+aFh.pspss.......tttGhRhDGRNLlcEa......K+pGapYVhsRp...pLlpspssp.sp.LLGLFtsuchta-l.....................pccsspsPSLtEMT-sAl+lLo.+Np......+GFFLhVEGuRID+ucH-scshtALsEsltFDpAlctAh-hs..p-c-TLllVTADHoHs......aohGuYs.+sspshGLusupsssDttshpll.asp...GsGtslcs.........................tt+.slst.scthts.apppuslshsocsHoGEDVsVaAhGPpAc.......hl+GlpEQTplu+sMstAhsL	.....................................................................................KNlIhhlGD.G.Mu.s...hsssR...h......t..t.....t.................t......s................................................................................ht...........h.......-t...........h....h.u...........psas.st.........................................lsDSAssuTAh.sGhK..o....ss..sl..u.ls...................................pt...p...h........olh..c..h.A.c..t..t..G.h.ss.GhVsT.scl...pcATPAuh.hAHsspRp..s..s...............................................................p.hhpt.......................h-..V.hhGG..G..t..p...a................................................................t.hp.s.t.s.L..h.pth.............p..t....t....u.....h....p....h.s......s.t.t...........th......t.............p.....t..s.....p....................l.l...G....L.....F......s....s...s.p........h.......ht...h................................................................................p..t....t.....t.....t.....P.........o..L...tpMsptA..l..p..h..L.....p.....p..st....................pG.FFLh....VE....G...upIDhttHsss......h..t...........ht-hhth-pAlphA....hp......h.s.........p...p.......t......p....TL.llsTADHsps.......................s.t...............................t.......................................s.........h.........t............t.................................t.....................................p...........h..h..................h.........................s....................................................................................................................................................................................................t...s...tt...Hsutp..l...lh.......A..h.G..s.t..t.t........................h...G.h-ps.h.hh.hh.h......................................................................................................	0	299	560	845
+37	PF02806	Alpha-amylase_C	alpha-amylase_C; 	Alpha amylase, C-terminal all-beta domain	Sonnhammer ELL, Griffiths-Jones SR	anon	ref [2]	Domain	Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the  active site, interrupted by a ~70 a.a. calcium-binding domain  protruding between beta strand 3 and alpha helix 3, and a  carboxyl-terminal Greek key beta-barrel domain.	21.20	17.00	21.20	17.10	21.10	16.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.74	0.72	-3.85	246	4792	2012-10-02 20:10:03	2003-04-07 12:59:11	13	63	3353	197	1256	4323	339	94.60	25	14.30	CHANGED	W....ssssslluFtR.............stt....hlllhN...hss..hppsh.psulP..sG....p........Yp-ll....susttph....us.......s......t.......h..............h...pGp........h..plpl....Pshusls.ht.h..p	.........................Wl.hpcsspslluFhRt.......................spt.t...llslhN...Fs.s.s.....s.p.p...sY..pl.GlP...sG..........p........Yp.-ll................NoDs.tpa....uGs......sh..spttp................lpt...............................hs..cGp..............l.plsl....Psh...uslhht...tt.............................................................	0	397	756	1059
+38	PF05111	Amelin		Ameloblastin precursor (Amelin)	Moxon SJ	anon	Pfam-B_6419 (release 7.7)	Family	This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and  sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which  is though to have a role in determining the prismatic structure of growing enamel crystals [1].	25.00	25.00	30.00	29.90	16.90	16.90	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.48	0.70	-5.73	4	141	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	79	0	27	129	0	207.90	45	100.34	CHANGED	MSASKIPLFKMKDLILhLsLLKMShAVPAFPQQPGs.....PGMASLSLETMRQLGSLQGLNsLSQYSRaGFGKShNSLWhpGLLPPHSSFPWhRPREHETQ...............QPSLQPpQPGhKPFLQPTAsTuhQsTsQKsuPQPPhH.GpLPLQ-uELPhscp.QVAPSEpPPsPELPshDFADPQhPo..........................lFQIARhISRGPMPQNKsS.LYPGMhYhoYGANQL...............GGRssPhAYGulFPGFGGhR.slcthPpNPsMGGDFTLEFDSPVAATKGPEKGEGGAQGSPl.EApssc.ENPALLSplAPGAHsGLLAhPpDsIPuhARGPuG+.pthL.uVTPAAADPLhTPELAEVYETYGADhTTsLG.ptEATMDoTMoPDT.QT.MPGNKspQPQhhH-AWHFQEP	.....................................................................................................................................................................................................................................................................................................................................................shtuhP.NPshGGDFTLEaDSPsAuTKGPEpt....EGGspssPh.-spsss.EsPAhLsEht..PsshuG.LLA.PpsslPsLsRuPuGp.+t...tVTPAsADPLhTPtLA-sYcTYsuD.TTsls.pcEs..Th..DsThsPso.po..hPtN+sppPphhpcs....................	0	2	2	6
+39	PF01510	Amidase_2		N-acetylmuramoyl-L-alanine amidase	Bateman A	anon	Pfam-B_735 (release 4.0)	Domain	This family includes zinc amidases that have N-acetylmuramoyl-L-alanine amidase activity EC:3.5.1.28. This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls (preferentially: D-lactyl-L-Ala).  The structure is known for the bacteriophage T7 structure and shows that two of the conserved histidines are zinc binding.	21.10	21.10	21.10	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.26	0.71	-4.10	117	7328	2009-01-15 18:05:59	2003-04-07 12:59:11	20	149	3627	173	1411	5665	2129	140.50	22	44.18	CHANGED	ttsttth..psphlllHpTssss..sts.t..............hhphps..............pssuhH...ahlst......cGp.....l..h.ph...hshs..........thuhH.su............................................h........Nst....s..lGl.phht.u....................................................sssQh.ps...ht..pL..hthl.........ppa.....s.ls.p........................plh..uH.......pcls...................sPush	...................................................tt.........phphlllHpTu.s.ss..spstt.h....................h...ts...............................pplusHal.lsp...................cG..p............l...h..ph...........lshs......................phuWH.AGs...........................................................................................h.Nsp.........S....IGI.Eltsst.........................................................................ttsh.ss.sph..ps.........ht....pL....sttl.............hppa...s..ls.p.............................plh.uHp-luspp...............sPu..h.....................................................	0	418	807	1119
+40	PF01520	Amidase_3		N-acetylmuramoyl-L-alanine amidase	Bateman A	anon	Pfam-B_888 (release 4.0)	Family	This enzyme domain cleaves the amide bond between N-acetylmuramoyl and L-amino acids in bacterial cell walls.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.22	0.71	-4.49	103	7380	2012-10-02 19:46:12	2003-04-07 12:59:11	13	197	3575	11	1463	5592	1358	194.90	29	50.10	CHANGED	lslDsGH.....G....Gp.Ds.....................G.....Ahu....ss....hh.EcslsLpl.upplt.ph.LpppG....hpVhhTRss.D.....t.h................sLppRsph..........A.....sp...hpuDlalSlHtN.uh............ssss......pGsplah...................................................ptptspupplApt...ltpp.ltpththt.......scG.......l+tss....................hhll..cp..sph.....PulLlEhGFloN.p-tphlpssphppp.lApuIspults	...............................................................................lhlDsGH.....G......Gp...Ds.................................G........AlG..................su......hp..EKclsL.p.l.Ap.clp...ph.Lpp.pG.......hclh.h.T.Rss..D..............hhl....................................................sL..p.p.Rs.ph...............A.........pp..........ppAD...lFlSIH.ss..uh...............................................ss..ss..s........pGsplah................................................................................................................................t.tph..ppuhplA....pt....lhp...p...lt..p..h.s.t.hp...................s+s.......................scp.us............................................hhVL....+p.....ssh............P.ul.LlEh..GFloN..sp.-..p.p.h.L.ts.sp.ap..pp.lApuIhpGlh.p.......................................................................................................................	0	519	1014	1265
+41	PF01593	Amino_oxidase		Flavin containing amine oxidoreductase	Bashton M, Bateman A	anon	Pfam-B_606 (release 4.1)b	Domain	This family consists of various amine oxidases, including maze polyamine oxidase (PAO) [1] and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines [2]. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium [3]. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines [1].  Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.44	0.70	-5.42	84	8963	2012-10-10 17:06:42	2003-04-07 12:59:11	19	111	2576	276	3844	15154	7049	357.50	13	77.77	CHANGED	luGLsAAppLtpt....Gh..............pVhllEAp-RlGGRlt..ohptt.....shhh-hGsphhh.s.ss.hhphhtphshp.phthh.tstthhhthphttt.hhthssth.........................................t.hhshtphhphttthtsthhthtpthhphtttsh...tphhhppshtphhht.....................................................................................................htshhhsthth..hthttust.hthhthth.shpptthhhshtt....hshhsthhsthts..ts...plphsppVpplphps.............ttststttsu..........thpsDt.Vlsssshsshp..............thhPthst.t.phh.pththssss.plhlphppthh.pt...................th.shhhsss...............ththhhhshphsss.....ttsshhshlhssts.....thhtshsccphhptlhpplpphhs.....th.ssh...............t..hppWtpsthstusashhsstss.....hhsthtssh.....................slahAGstsstth..sslpGAlpSGhpsAppll	..........................................................................................................................................................................................................................................................uGLssA...h.....L.....t.p.t...........uh................................plhl.hE......t......p....s........p.h.G.G.+....h.............s..h.....t..t...................sh..h....h..-.h....G...s...t.....h....h................................h.........t...h.....h.....t...............t.......h....h......................t................h.............................................................................................................................................................................................................................................................................................................................................................................................t.................................................t....h.............................................................................................................................................................................................................h...........h...h...............................t.................h............................h......................................................................................................h..................t........................................t..h........t.......h.......t...h...h...h...t........t..............plp..h..s...p.........V...pp.lp.h..ps......................................tt.h..t..l..h..h..t..sst..................................................hp.s-h..l......lh.s.s.s.h.t..hht........................................h...s.......h.s..t.................t....h........h...t........t.....h................h.....t...s.........s....hh..h....h..........h....t..t.......h.h..............................................................................th.hh.t......................................h......hh......t..................................h..h.....h......h..h...h..t........................................h..t...h....s.............p.....t.....h....h....t.........h.h.....t......l.t.p....h..hs.................t.................................................................t.h..........................h...........h..............h...t................t....................h..............h..t...............................................................................tlh.hsGt....h..t...........................h.h..ssh.su...s......................................................................................................................................................................................................................................................................................................................................................................................................................	0	1229	2344	3195
+42	PF00501	AMP-binding		AMP-binding enzyme	Finn RD, Eberhardt R	anon	Prosite	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.67	0.70	-6.09	354	67453	2012-10-02 15:58:18	2003-04-07 12:59:11	23	2256	6205	141	23415	62718	26362	376.00	19	52.12	CHANGED	hppps...pptP.cps.....Al....h..............tspplTYp-LppcusplAphL..t.p..h.Gl.p..tsc.h..Vulhh.pss-hlluhlAlh+sGushlPl..ss......shss.....cclthhlpcu.......psphll...s.............................................t.......hhhhp.......t....tt...................................................t.....sch...Ahll..Y..TSGoT....GpPKGVhloH.psl....hsh.hs.............ht.......tt........hh.hth.ss.......hsashu...h.htlhssLhtGu............................slllhpt..t.hs....thh...hp....hlp.c......hplT...hhhssPshhp.hl.......hp.t...t........................................ths...................s.L......+h..................................................l..h.......s..uGpslssphht.hpphhtt........lhss.YG.TEssshs.....................hhh...................ttt...hs.l.G...pP..l.....s.ssphtll..Dtt.tp.l...s.....sG.s...GE...lh.lp....Gs....s..lhcGYh........s.c...P.ch.....Tscp.ah......t...........................tt.ha+TGDlup.h.p.....D.G....h.lthlGRhc.c.lKlp	.......................................................................................................................................................................................h..........s...pt..Al...h..............................tttpho....a...t..p.....l....t....p..........p....s....p..p.h....A....t....h....L...........h.....t.................h.....G......l....t..............................s.......sh....................V.u...l.h...h...........p..s......................p..............h....h...........h......s.....h..h..u.h...........h.........p....h...............G....s......s....h.........s....s.....l.......s...s.....................................t.h..s..........................p...p...l.....t.....h.....h..l.p...p..s........................t..s.p....hll.................................................................................................................................................................................h.....h.....h.........h....p.............................t....................................................................................................................................................................................................................................ts......pch.....s...h....l..h......a........T........S.....G..o.....T..................G......p....P..........K............G..........V...h.....h.....s.....+.....tsl....................hs.t.h.h.t.h.........h.............t.......................................-....hh..hth...hs......................h.h..a..s....hu................h....h.t..hh..s..s.......l.....h....t.....G..u...........................................s.h...h.l.h.......s.......t.....h...............tth..................hp...............................hlp....p........................h.....p..s..o............h.h.h.s..s...P.s..hhp..hl.............................hp..t....................................................................................................................................shs...............s...l...+.h.................................................................................................................................................................................h...h.......................s.......uG..p....s...l..s...s......p......h..h......p......t......h..t..p.hhs.....................................l.h..p.s...Y.....G.................T.Essshs...............................sh.................................................tt....p.h.s.s...h..G.................ts.......h........................s...s...h......p...h...t......ll................D.t...p................h..p..h...........s..................................ut..............GE................l..h....l.p...............Gs.............s......l.h..p.........G......Y...h...........................p...p.........s...ph.....................o..t..pt...hh...s...........................................................................tt..h.a..c...T...G..D..luh..h..p..............t.........c..G..........................h...l....h....h..h.G.Rh..c..c...lhh.t................................................................................................................................................................................................................	0	6394	13492	19232
+43	PF05195	AMP_N		Aminopeptidase P, N-terminal domain	Finn RD	anon	Manual	Domain	This domain is structurally very similar [1] to the creatinase N-terminal domain (Pfam:PF01321). However, little or no sequence similarity exists between the two families.	20.40	20.40	21.80	20.90	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.84	0.71	-4.77	154	2593	2012-10-02 11:23:57	2003-04-07 12:59:11	11	16	2060	51	934	2167	1097	135.80	28	29.60	CHANGED	hstptatpRRpcLhppht................sulsllsuuspthRs.sDscYs.FRQ-Sp.........FaYL..................TG...asEP-ulhll.........ptp......t.lLFspt+-............ptElWsGhRhG.-sAhctausDpAasls-...lsphL.sphlpstp..t...laash..s.pssthc	...........................................tppatp.RR.ptLhp.pht......................suhsll.uus.ph...h..R....s..sD.s.c.Y.s.FRQ..sSs..............FaYl...................TG....h...s...E...P-.ulllL........................ststs......cslLFscs..+c.................ptElWh.Gt.Rh..u........-..t...A.pph.G.l..Dcsh..shs-.......ls..phL..phl..tths..h...lahs............t.........................................................................	0	292	563	795
+44	PF03098	An_peroxidase		Animal haem peroxidase	Bateman A	anon	Prosite	Family	\N	19.30	19.30	19.70	19.80	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	530	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.83	0.70	-6.13	123	2338	2009-01-15 18:05:59	2003-04-07 12:59:11	10	150	421	314	1401	2365	62	385.50	22	55.96	CHANGED	YRoh-GpsNNh..ppP.thG..ssss.asRh.lsstY..tcuhspsts............tth.LPs...........sRt.l..Spplh...tptp.......................hssssph....ohhhh.au.QalsHDhshssps.................C.t............t..shs....l.ls.sDshhs..........sh.hhRoh.s...ss.t.....................tpQ..............................lNphTualDuS.lYGsspptsppLRs...hpt.....GpL+...........ss.s...hhshs.........p.h..................hhhsG-tRssp.suLsshpslahREHNplAcpLpp.............h......................sPc..........................................................................................WsDEp..laQcARpllsA.........................h.Q+.................................IshpEalPtlL.Gp.p...shph.hh..............................................................hps..............Ys.slssslssEFtsuAaRahHohlssthhhhtpph................................tl....lpcthassp...hhpp.........................ls....hl.hGhhs.....................................psutphc...phhssplpppl..a...phstt........h.DLsulsIpRuR.D+GlssYNpaRchhs......Lpshpoac-ltt..........hssppl.............................hppLpplY...................................sss-slDlalGulsEp.h...Gu..............hhGsoh......ssllspQFp+h+pGDRFaa....E...ss..........................s.FTtpplpplp.....ps.oLscllscs.....h.th...tp..ht..ssF	..............................................................................................................................................t..h.R...h...s...................................................hP............st..l....hh.....................................................................................................................t......s.hh.......h.au...phh.a.ph..s.....................................................................................................................................................................................................hs..hothlDhu.lYGp.......s........t..t..tl.....R.......t..........G.hht............................................................................................................................h..h..u..p...h.h.....s......hl.....h.hthlahR.HN................h...lsp..L.tt......................................p..p......................................................................................................................................................h..ss-p.....l.....a....ppu.......Rhl.hh...u..........................h..p......................................l.sh.-al.hlh.s..........ht............................................................................................h.s................hp.....thsstl..s.F.shs.a+.a......Hshl.s.h.hhstph..........................................h........p.h..h....t..........h..h.t.......................................t...........hh...th.t............................................................................t.hst......t..ltp.h........h.........t......................cl..shsltcuR.c............h.....s.ls.shsphR.t...h.h.s....................................h......hp....s..ap-h..........................p.....t..h...............................................tthtthY...........................................................................tp..pt..l-la.GhhhEt...........st.................h.G.hh..............................phhh.ph.....t..............h.h...uD...+...hhh.t.....p...........................t.h.s...th..t.l.........p...sh.plhh.................................................................................................................................................................................................................................................................................	0	473	646	1103
+45	PF01821	ANATO		Anaphylotoxin-like domain	Bateman A, SMART	anon	Prosite	Domain	C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to a three-fold repeat in fibulins.	21.40	21.40	21.40	21.50	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.24	0.72	-3.82	65	552	2009-01-15 18:05:59	2003-04-07 12:59:11	13	71	77	20	202	520	0	35.50	37	3.14	CHANGED	CChDGhptss..hspoC-cRsthl.........tpsppChpsFhpCC	...CCt-Ghptts..hspoCcpRsthl............ps.tCtpsFhpCC.....	0	14	34	79
+46	PF01094	ANF_receptor		Receptor family ligand binding region	Bateman A, Finn RD	anon	Prosite	Family	This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.96	0.70	-5.66	119	7015	2012-10-02 13:57:41	2003-04-07 12:59:11	23	144	390	116	4127	13698	3388	312.90	15	40.55	CHANGED	thttAhphAlcclNpsss.hh...sshplshthtss.............................sstt.....ssshstphhtpptlhull..Gsssos.sstssuplssth..pl.Phloh.........................u.usssthss....tp..ashhhR..sssssptt.spuhscllpp..................asWppluhlhssssh...spth.......hpslppthpph.th.hhth.........tth.spspshp..shhptlpp.....pps+lllhtstssph......ptlhpps.......t.th..ttta.halhhshh.pt.....................................htstphtcshpuslshphhtstt.thpphhpphp...........................................................................ttt.shhshhhYDulhhhApAlpphhpppssthtst......................................................................s.tlh.phhps...........spa.......pGhsGplphsptssph.shthhhhphp	...........................................................................................................................h.huhpt.h.s...t...p.......h.................t....h..p..l..t....h.....h....p.......................................................................h............................................t.................h...h..u...lh.......G..s......s.st..................s..........................h......s....p..h...h.....t....h..h............pl....P................l.....o...h....................................................s...s....s...s.......h..ss...................t.p...as...........h.hp....hh.s..........s.....t...............t..............s....t....u......h...h....p....l.l.pt...................a.t..W.....p......h...l..s.h.l...h.....s...s.s..ph.........h..h.........................................hp.t.h.pp.....h...pp.....t........h.shth...............................h...t.....t..t...p.............p.......th.......p....l..p.p.......................t..............p.....sp...l.l..l..l..h...s..p..t.p.th.............................................ttlhpt.h....................th.......t....t....h....h..a....l.h..s.s....h.h....t...............................................................................................h.h.t............h..t....s.....h...h......s.....h.....t.......h..................p............p..................t...h.....p...p....a...h...t.p.h.p...............................................................................................................................................t..h......t.................s..h...h....a....s..AV.....h...s...h...A..h.....A.l..p.p.h...h...t...p..................................................................................................s.....p...l..h...p.hh..h.p.......................................h..p.h.................................................p.s....s.G..p.....h...p..ts...t..............h....................................................................................................................................................................................................................................................	0	856	1347	2917
+47	PF00023	Ank	ank; 	Ankyrin repeat	Bateman A, Sonnhammer ELL	anon	Swissprot_feature_table	Repeat	Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity [2][3].	20.60	14.70	20.60	14.70	20.50	14.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.19	0.73	-7.67	0.73	-3.89	1072	8812	2012-10-02 12:10:21	2003-04-07 12:59:11	25	2020	897	214	5230	139773	9187	32.40	29	5.11	CHANGED	pGpTsLHhAspps......................phpllchLlp....tuushshpsp	..............................................................................G.TsLH.h.A..stps............................................................................phcll.chLlp.........pGAshph.........................................................	1	2564	3256	4303
+48	PF00191	Annexin	annexin; 	Annexin	Finn RD	anon	Prosite	Family	This family of annexins also includes giardin that has been shown to function as an annexin [1].	20.90	20.90	20.90	20.90	20.20	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.96	0.72	-4.07	177	6936	2009-01-15 18:05:59	2003-04-07 12:59:11	15	27	307	347	3328	6752	29	64.80	29	64.50	CHANGED	hDAp.hLcpAhcshG...Tc-psllcIlsoRoptphppIpptYpptau.+sLpcslp.s-hSGcacchLlsL	.....................................-Ap..hLc.pu..h..+.G..h.G.............TD.E....ps...l...l....c..Il..s..s...R..o.p..t..p...l..p....p....Ip.p...tY.........p........p........h..a..s.....+......s..L.tc.....slc...s.......-..h....S.G.ca.cchllsl.....................	1	791	1389	2220
+49	PF03861	ANTAR		ANTAR domain	Yeats C	anon	[1]	Domain	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the  domain consists of a coiled-coil. 	20.10	20.10	20.10	20.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.33	0.72	-4.39	179	2458	2009-09-15 11:05:26	2003-04-07 12:59:11	9	45	1401	6	888	2155	145	56.00	30	24.33	CHANGED	phpplcptLpsRc........hI-pAKGlLMpp.ps..ls.EpcAachLRctuhppshpltclAcpll	.................................htplpptLpsR+.............ll-pAKGlLMpp.ps..lo.EpcAachLpctuMcpphplt-lAptll................	1	317	595	768
+50	PF04729	ASF1_hist_chap	Anti-silence; 	ASF1 like histone chaperone	Mifsud W	anon	Pfam-B_3167 (release 7.5)	Family	This family includes the yeast and human ASF1 protein.  These proteins have histone chaperone activity [1].  ASF1 participates in both the replication-dependent and replication-independent pathways.  The structure three-dimensional has been determined as a a compact immunoglobulin-like beta sandwich fold topped by three helical linkers [2].	20.70	20.70	22.80	23.80	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.76	0.71	-4.58	24	449	2011-09-19 02:26:53	2003-04-07 12:59:11	8	4	313	29	308	425	2	145.60	53	66.27	CHANGED	M.S...hVslpslplh.sNPusFpsPapFcIoFEslpsLp-D.....LEWKllYVGS...............................Apspca...............................................DQhLDslhVGPlst.GhppFsFcussPshppIP....p-llGVTllLlossY+spEFlRVGYYVNNpYp-pELcENPPs.....ps.l-+lpRpIlsscPRVTRFsIsW-	................................MuhVplhsVtVL.sNPu.FhsPapFE.IoFEClE.sLpcD...............LEW...KllYVGS...............................................AcSc...ca..................................................DQ.LDSlLVGPl.Ps.Gh........ppF.lFpA..............Ds.Psssh.IP...psDhlGVTVlL.lT.C.oYcGpEFlRVGYYVNNE.Y.s..s..t..EL......+.....E.s......PP.s..............KP....h.-+lpRNIL.AppPRVTRFtIsW-...........................	0	115	168	246
+52	PF02822	Antistasin		Antistasin family	Bateman A	anon	PDB	Family	Members of this family are inhibitors of trypsin family proteases. This domain is highly disulphide bonded. The domain is also found in some large extracellular proteins in multiple copies.	21.20	21.20	21.40	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.67	0.72	-3.63	60	460	2009-09-11 13:25:17	2003-04-07 12:59:11	9	70	93	8	298	535	14	27.10	43	9.73	CHANGED	Csthp..C...phtCshGappD.p.sG.Cp...h.CpC	..................Cstlt....C..........phtC.s.aGFppD.p.pGCp...h..CcC	0	107	126	218
+53	PF00847	AP2	AP2-domain; 	AP2 domain	Bateman A	anon	Pfam-B_409 (release 3.0)	Domain	This 60 amino acid residue domain can bind to DNA [2] and is found in transcription factor proteins.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.71	0.72	-3.81	206	5868	2012-10-03 08:51:45	2003-04-07 12:59:11	15	52	728	5	2816	5799	189	52.10	39	17.05	CHANGED	sth+GV..phcp.hs+...Ws..Aplh................t...pphhlGpass..-..cAtpshptsthphpst	.....................tYRGV....Rp+t....hG+...........Ws..AEI+c..s.........................p....pRlWLGT...FsT..sE....cAA+AYDtAAhph+G.......................	0	596	1740	2384
+54	PF02424	ApbE		ApbE family	Bateman A	anon	Pfam-B_1963 (release 5.4)	Family	This prokaryotic family of lipoproteins are related to ApbE from Salmonella typhimurium. ApbE is involved in thiamine synthesis [1]. More specifically is may be involved in the conversion of aminoimidazole ribotide (AIR) to 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP).	20.00	20.00	20.20	20.10	19.00	19.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.54	0.70	-5.10	245	4122	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	2989	11	985	3311	1196	240.90	28	74.58	CHANGED	lpclsp.hSs..a..c..ss...S-lsclNpsss.hp..h..tlss-hhp..llppuhclsphosG...sFDsTl.GPLh.sLW.......uFssp............thPs...tppls................pthth..sshpp.hh............ttphhhppsshtlDLuuIAKGausDplsph.L..ppt..........Glp.shlVphG.G-ltsh..Gpp....pup.........s.......Wplul..p..s..P..............................ppt..........phht..hl.....plps.t...uluTS..G.sYcpaa.....s..Gp+apHllDP...pTGhPhp...pphsSVTVl..usss....ht.....ADuhuTulh..lh.G.....cp.uhphscp....ps.........ls.s......hhl	..............................................................................tthcphhSsa.p.....ts.....Spl...clNp.....ts......u....h......p.....sh........tl.s.t.phhp.llp.huhchuttosG....thDlol.GPLl.phW.........thG.pt................sphPs.......tp.pl..p............................................thh....t..h.....s.s.hpplhh.....................tppp..l.hhpp....ss.htlDLuulAKGYusDplsp.....h.....L..cpp.......................................Glp...shllsl.G.....G.s.lhsh......Gtp........sp.sp.........................s...............WpluI...p..c...P..p............................................tps.shhs.....hl....plss...t................ulsTS...G.sYc.pah..p....hs...............Gpc..apHllDP..........pTGh.....Plp...pp.....lsS.V.T.Vl.....u.s..s.u.............h.p............A.DuhuTulh.....sh..G.........pp....uhphhpp......ts....lt.shhl...............................................	2	336	675	848
+55	PF04049	APC8		Anaphase promoting complex subunit 8 / Cdc23 	Wood V, Finn RD	anon	Pfam-B_13808 (release 7.3);	Family	The anaphase-promoting complex is composed of eight protein  subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6),  and CDC23 (APC8).	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.99	0.71	-4.46	26	298	2009-09-11 06:08:17	2003-04-07 12:59:11	8	107	258	0	221	308	6	146.10	29	24.42	CHANGED	Mssp.......slpcl+ppLhtushpho-+sLhQSAKWu........AEhL.uLs.........................................ps.hsspsstpsttp...........spEh.-tYLLAKSYFDs+EYDRsAahLcssp...............................................SpcuhFLtLYupYluGEK+cpE-sptslssts.........sstNcchs	................................................h...........htpl+hpLhtuhhphscRsLhpuuKWu.....................AEh.L.uLs..................................................................................s....h.ts.ss.ptt.t...............................p-h.stYh..LAKoYFDs+EYDRsAahlps..sp....................................................op+uh..F.LthYupYLuGEK+..+p-.-p.t.hss.p.................................................................................................................	0	76	124	184
+56	PF04106	APG5		Autophagy protein Apg5 	Wood V, Finn RD	anon	Pfam-B_12134 (release 7.3);	Family	Apg5 is directly required for the import of  aminopeptidase I via the cytoplasm-to-vacuole targeting  pathway [1].	20.30	20.30	21.40	21.20	20.20	19.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.15	0.71	-4.83	34	341	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	279	5	222	339	2	200.20	30	65.17	CHANGED	WahPlGlLaDLhsssssh........................................................PWplplHass....aPsptLl.hssc..........cslcstahsslKEAsal+sGs.......scsIhshscpDpppLWpulhs..cshcpFhpIspKLh............................s.psth+pIPlRlYlsss..................hthlQphlpsh.................tpsp.h.TLt-hLpphLPshh.................................................stp..........ptphspsllpGIclsh..csPlp.lscphsasDsFL....aIslhhh	........................................WahPlGlLaDlhs.sss.h..................................................................................................................................................................................................................PWplsl.Haps....aPpp.Ll..hssp.......................cslcstFhsslKE.......ADhl+pts........psl.s.hp+cDp.ppLWtul.s..c........cac.pFh..tlsp+Lh.....................................................................................s.ttssh+pI.....PlRlYhsss..................................................................h.hlQphh..t..sh...........................................tpsp.p.TLschLpplh.Pshh...............................................................................................................................tp..................t.thspshlpG..l.pssh....csPlt.lscphu.asDsFLalslh.............................................	1	76	119	183
+57	PF04602	Arabinose_trans	arab_transf; 	Mycobacterial cell wall arabinan synthesis protein	Waterfield DI, Finn RD	anon	Pfam-B_4670 (release 7.5)	Family	Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the   macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1].	25.00	25.00	28.00	27.90	17.90	22.20	hmmbuild  -o /dev/null HMM SEED	657	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.09	0.70	-6.34	7	497	2012-10-03 03:08:05	2003-04-07 12:59:11	7	7	176	8	90	457	0	565.40	47	61.09	CHANGED	cussps.RIARhVAslAGlhGhlLslssPLLPVpQTTATlpWPQ....sGplsplTAPLluhsPpsLslTlPCpAsAsLPsss....GlVlSTsPttGh-AscsGLhlcsspssVsVshRssVsssAPRstVsu....ssCphlchhAsssussA-FVGlst.....suGp.......ss-hRPQlsGVFTDLpsPAssGLuhpssIDTRF.TuPTsLKhhAMlLGlssslhAllALthLDphsttth+h...hlPhtW.................hssthsDssVlusLllWHllGAsoSDDGY.LThARVup+AGYhANYYRaFGosEuPFsWYaslLAhhApVSTAulWMRLPshlsuluCWLlISRpVLPRLGsu...lsssRsAhaTAGuhFLAAWLPFNNGLRPEPlIALGlLlTWsLVERAluhpRLhPsAlAhllAhhTlsluPpGLIAlAALLsGuRsltplltRR+ptsGhhs.lAPLhAAsoVlhhllF+-QTlATVlEus+lKhsVGPolsWapEaLRYYaLhlto.sDGSluRRFAVLshlLCLFsslhhhLRRu+lPGsApGPsWRLIGhThhohLhLhFTPTKWshpFGsFAGLuGulGALsAhAsophuL+oRRNhslalsAlLFVLAhuhAulNGWaYVSNaGVPW.st.PhlstaslTohFLsLollsuLlAuWhHFph	.............................t.........h..+hhAhluG...llGh..lLslhsPlLPVpQssAplsWPQ...............sG...p.h.s.....sls..APLluhsPhshsholPC.ssht.....s...Lss..st................slllu.ThP.tt..u...c.A...st...p...uLhlps........s........t......s......t......lsls.Rssslh.s.sshppl...u....ssC.ptlpltustst....stA......phsGl.t.............sGs.....................................s........shRPQlsGlFTDL.......p.......s.....s.......A......s....s.....G..........L...shpsslDoRasooPTsLKhhshll.ulhh..slsuLlALhhLDp.h.-Gt..pth.c..................hhP.spW...........................................................hp....phhDssVlusLlhWHhlGANoSDDGYlLsMARVupcAGYhuNYaRWFGsPEuPF.GW.YYslLAhhspVSs.Aol.W.MRLPsLhsulssWhllSRcVlPRLG.u....ltss+..sAh..WsAAhVFLuhWlPaNNGLRPEPlIALGsLl.TWs.lERulutp.RLhP.uAlAslhAuhTLssuPoGLhAlusLls.uhpslh.pllh.+.............R.............p..................t......h.........................G.............h.h....s....h...lA......PhhAAuollhhslFtDQTLuslhEus.+l+ttlGP...ohsWapEhlRY.hLh.h.o.sDGSluRRFulLhhhlsL.hssl......hhhLR......+..t.RlP..GsAtGPs.hRl....lGhh....hhohhhhhFTPTKWsHHFGlaAGluuul..uAls.slshuth.sh+.sp...RNRshah..u.u..l......l.F.l..hAhuhuuhNGWWYVusaGVPW.st.Ptltuhsh...oohhL...s....Ls.llshhhAsW.Hhh..........................................	0	15	61	81
+58	PF03079	ARD		ARD/ARD' family	Mifsud W	anon	Pfam-B_2276 (release 6.4)	Family	The two acireductone dioxygenase enzymes (ARD and ARD', previously known as E-2 and E-2') from Klebsiella pneumoniae share the same amino acid sequence  Swiss:Q9ZFE7, but bind different metal ions: ARD binds Ni2+, ARD' binds Fe2+. ARD and ARD' can be experimentally interconverted by removal of the bound metal ion and reconstitution with the appropriate metal ion.  The two enzymes share the same substrate, 1,2-dihydroxy-3-keto-5-(methylthio)pentene, but yield different products. ARD' yields the alpha-keto precursor of methionine (and formate), thus forming part of the ubiquitous methionine salvage  pathway that converts 5'-methylthioadenosine (MTA) to methionine. This pathway is responsible for the tight control of the concentration of MTA, which is a powerful inhibitor of polyamine biosynthesis and transmethylation reactions [1,2]. ARD yields methylthiopropanoate, carbon monoxide and formate, and thus prevents the conversion of MTA to methionine. The role of the ARD catalysed reaction is unclear: methylthiopropanoate is cytotoxic, and carbon monoxide can activate guanylyl cyclase, leading to increased intracellular cGMP levels [1,2]. This family also contains other members, whose functions are not well characterised.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.82	0.71	-4.28	11	964	2012-10-10 13:59:34	2003-04-07 12:59:11	9	12	776	3	436	1144	153	149.50	30	82.56	CHANGED	phahh--psp.Dp+lPccpsPtchhphpcLsclu.hhha+lsscsppsscchpplhch+shshhsh..........spssscphPpa--KlcpFaEEHlHsD-ElRahlcGsGYFDV+..sps-sWIRlhlcpGDLIllPsGIhHRFTsssssalKAhRLFsssstWss	.................................................................................................................p.t.t...p.hs..t......t...........tlt..h..h......ch.s..t.s..................s.s.p.p..h..t.hltthp.sh..t.h..................l.hshps.s..t..P.s....h....-....p.h....lppF.hpE....H.hH.s.D.-.E.lR.ahl.sGpG..h..F.s.l+.....sp.s.....ct....ahclhscp.GDLIslPAGhhHh.F..s.h.s.s........s.s.h..lp.A............lRlFssp.sWss..............................	0	130	246	354
+59	PF01412	ArfGap		Putative GTPase activating protein for Arf	Ponting CP, Schultz J, Bork P	anon	SMART	Domain	Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.	27.50	27.50	27.50	27.90	27.00	26.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.97	0.71	-4.31	141	3394	2009-01-15 18:05:59	2003-04-07 12:59:11	13	165	341	30	2020	3186	33	114.20	32	18.59	CHANGED	pphlppltp...h.ssN.phCsDC...s..stsP.pWsSls.hG.....lalClcCSGl...HRs.LG..s.......HlS+V+SlsLD..p..Wsscplphhpth.GNp.pssphacsp.....................sst..........ssppphcpaI.ppKYtp+t.as..pst	.....................................p..hhpplhp..h.ssN...phCsDC....s............u.s....P...pWASls.hG............lhlClcCS..Gl.H.R..s.LG.s.............................H...lS.+V.......+....S..ls.LD........s.....W.ss.p.......p..l......p......h..........h.pph...GN.s.t.ss.p..haEsp................................t...s.ss.......................ssppphcp.aIpsKYpp+tah..t....................................................................................	0	652	1022	1510
+60	PF01388	ARID		ARID/BRIGHT DNA binding domain	Bateman A	anon	[2]	Domain	This domain is know as ARID for AT-Rich Interaction Domain [1], and also known as the BRIGHT domain [3].	21.00	21.00	21.00	21.30	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.86	0.72	-4.13	53	1730	2009-01-15 18:05:59	2003-04-07 12:59:11	16	96	289	17	1077	1669	7	89.90	29	8.00	CHANGED	pspspppppFlcplhpFhcppGss..........h.tchPt................lst+.lDLapLaphVpchGGhc......pVscp+p........WsclupcL..shss.....ttssu...........ppL+stYt+hLhsYE	..................................................t.....tctpFlppLhpFhc.p.p...G...s.s................................h..p+.h.Ph....................................l..s.t+.LDLapLaphV.p.ch.G.G.hp....................p.V.sp..p.+t.............................W.p.clsppL..sh..s.s........s.pssu...................s.sL+ptYp+h.L.hsaE........................	1	277	474	782
+61	PF04683	Proteasom_Rpn13	ARM_1; 	Proteasome complex subunit Rpn13 ubiquitin receptor	Waterfield DI, Finn RD, Coggill P, Wood V	anon	Pfam-B_4497 (release 7.5)	Family	This family was thought originally to be involved in cell-adhesion [1,2], but the members are now known to be proteasome subunit Rpn13, a novel ubiquitin receptor. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain [4]. The domain forms two contiguous anti-parallel beta-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold [5]. Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37 [5].	25.00	25.00	25.70	25.50	22.50	24.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.14	0.72	-3.90	78	393	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	279	4	246	369	1	86.10	40	26.93	CHANGED	G+hphc....s......phVpPcscKG.hlhlhpsc.-....sl............h+FpWpsRss.......spsEp.......-lll..hPs-spFpclsps............psGRVasL.+Fpsusp+.hFFWhQ-t	..............G+hplc....s......phVpP-t+KG.hlaltp......s-.D.......sL.................lHFsW+sRss.........spsEc................DLIl..hPsDspFp+V..sps............soGRValL.KF.pu.....uspR...hFFWhQ-...................	0	78	132	204
+62	PF00514	Arm	Armadillo_seg; 	Armadillo/beta-catenin-like repeat	Bateman A, Ponting C, Schultz J, Bork P	anon	SMART	Repeat	Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.	20.60	20.30	20.60	20.30	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.45	0.73	-7.89	0.73	-3.96	242	12724	2012-10-11 20:00:57	2003-04-07 12:59:11	18	321	451	497	7518	13312	326	40.80	24	18.23	CHANGED	ssp.ptphll..psGslshLlpLLp......sps.plpppAshuLsNlss	..................tptphll..psGs.lshLlpLLp...............sss.pl.pp.p.AshALsNls.......................	0	2088	3612	5404
+63	PF00339	Arrestin_N	arrestin; 	Arrestin (or S-antigen), N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Ig-like beta-sandwich fold.  Scop reports duplication with C-terminal domain.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.74	0.71	-4.39	42	2044	2012-10-02 22:29:00	2003-04-07 12:59:11	24	33	301	26	1377	2143	4	138.80	19	29.63	CHANGED	hslhls....p.chlaasG..-sl......sGpVll.sspp.hcs.RtlhlplpGts+sshpc.cshshphpc.............t...p....shhchpphLhpp..............h.hGsasaPFpaplP...ss.PsShpuphG........tlcYpl+shl....-ts.hchspp...pppshhVlphlshs	..........................................................................................................................h.ht....p..t......h..ss.......p.l............sGhlh..l....p......t.....h......ph...p..t.............l.hlphput..hcht....h...p...p.....ps..h...s..p...tt.......................................................................p.t....th.h.p.hp.t.t....l.h.tp..........................................h.........G..p.a..p.....a.P.F.ph.p......l.....P.......t.s..h....P.....s..S..h..p....h.p....G......................................tl.pYp.l.cuhl...............cps.....t..h...p......hpp.hhllp.h...........................................................................	0	452	648	1092
+64	PF02752	Arrestin_C	arrestin_C; 	Arrestin (or S-antigen), C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Ig-like beta-sandwich fold.  Scop reports duplication with N-terminal domain.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.69	0.71	-4.06	173	1981	2012-10-02 22:29:00	2003-04-07 12:59:11	17	29	291	26	1311	1936	0	151.20	19	30.82	CHANGED	tsstlphplslsppuas.Gpslslplpls.......N.pos.hs.........lpplphpLhpphpahspt.......................................................................ppp.ptpphlsp..pttssl....................................tstppsphp..hpl...........plP...........................................................slss...os.........................................................psphIplpYplclplphs........................t..plphplPlhl..hps...sh	..............................................................................................................................................t.ps.lplphsls+..ps.as.....G.-s...lsl.p.h.pls.......N.po..s.hs.....................lp...plcsp...lh.pph...shhsp...............................................................................................................................................................................................ppp.phpphlsp..tpstsh............................................................ssss..shp.......hpl......lP..........................................................................................................................slss.......ohh.........................................................psphIpl.pYp.lc....lplpls.........................................t...httcltl..clPlhlhp......................................................................................................	0	417	606	1041
+65	PF04959	ARS2		Arsenite-resistance protein 2	Moxon SJ	anon	Pfam-B_5269 (release 7.6)	Family	Arsenite is a carcinogenic compound which can act as a co-mutagen by  inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance [1].	21.10	21.10	21.20	21.70	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.52	0.70	-4.15	8	282	2009-09-11 08:45:49	2003-04-07 12:59:11	8	12	212	1	189	287	1	200.40	25	26.08	CHANGED	MPNRCGlIHVRGPhPsN.RITpsE..............................VsEapKoaEEKLuPLLuh+-sLSE-EApKMG+KDPEpEVEKFVoANTQELuKDKWLCPLSGKKFKGPEFVRKHIhNKHu-KlEEV+KEV-FFNNYLtDAKRPuLPE.KPh.sPGsst..ssshuP.uhs.YsPQ..sPQuhhPaGtP...RPPhhGa........s....GGPsFPPs.aG.......................uGRGNYDsFRGQssthuhP+s.R.hcGs	.........................................................................................................................................................................h......p..a...+s..h-pKl..h.Lp....p...p.................-....h..pK..hGt.K...s.....s...-....p....tl.Echlp...t.s..pc..scs..K.....ahC..Ph..s.......u..KhFK..us-Fl+KHlhpKHs....Ehl....c....c..l...+...p....E...l...t...aaNN...Yl.....h...D...Pp+..P.s.h...sc.........t...t.....s....s.s..............................t.s......s.......a....t.....................h..................................................................................................................................................................................................................................................................	0	65	107	155
+66	PF01037	AsnC_trans_reg	ASNC_trans_reg; 	AsnC family	Finn RD, Bateman A	anon	Pfam-B_773 (release 3.0)	Family	The AsnC family is a family of similar bacterial transcription regulatory  proteins.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.17	0.72	-4.27	263	13775	2012-10-02 00:20:33	2003-04-07 12:59:11	16	36	2996	126	3987	9832	2190	73.20	21	46.93	CHANGED	ltlplp.pp.........hcphtctltp......hPEVhpsatloG.shDall+lhs.pshpshpphltp...ltplssltps.poplllpp	.......................................................lplp.pp.........hpphtptlpp...........hs....E..V..h.psahl.oG..chDall+lhs.p......sh.pphp..chltch....l...t.p...lsu...l.pps.pohllhp............................	1	944	2215	3156
+67	PF05118	Asp_Arg_Hydrox		Aspartyl/Asparaginyl beta-hydroxylase	Finn RD	anon	Pfam-B_2775 (release 7.7)	Family	Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes.  Proline 3-hydroxylase hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure of proline 3-hydroxylase contains the conserved motifs present in other 2-OG oxygenases including a jelly roll strand core and residues binding iron and 2-oxoglutarate, consistent with divergent evolution within the extended family.  This family represent the arginine, asparagine and proline hydroxylases. The aspartyl/asparaginyl beta-hydroxylase (EC:1.14.11.16) specifically hydroxylates one aspartic or asparagine residue in certain epidermal growth factor-like domains of a number of proteins [1].	20.10	20.10	20.10	20.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.92	0.71	-4.41	11	1101	2012-10-10 13:59:34	2003-04-07 12:59:11	10	40	713	5	388	906	1501	146.90	31	44.69	CHANGED	pLppNWptIR-EuLtLts...httuttas-tuasshhKssWcpahLhhhsstpssAtphs.PpTssLLcplPpspu.................shFupL.PGuclhPHpDPasus.....lRhHLGLsTP.s-tChIcV-spcpsW+-GEsllFD-oa.H.utNpo-psRllLhhDl.+P.	............................................................................h..ptpW..IRpEh..tl................t.........t...........s.........s..........s........h......ct...sWcp..F..hL..h........hh...s.t............t.h....ss.....s.t.............p..hC....P.....pTs.pl..l.p..p..l.Pshpu............................AhFuhL..sPGscls.Hc..s...P....hsup.........lRhH.L..GL.h.......sP.....p.............s......t............C....hl.....p..V.....s...s.....p.....p.....h....s....W.c.....-.....Gcs.llFD.-o.a.H.shN..c.....s...s.....p......s...RllLh.sDl.+P...............	0	129	195	286
+68	PF01177	Asp_Glu_race		Asp/Glu/Hydantoin racemase	Finn RD, Bateman A	anon	Prosite	Family	This family contains aspartate racemase, maleate isomerases EC:5.2.1.1 [1], glutamate racemase, hydantoin racemase and arylmalonate decarboxylase EC:4.1.1.76 [2].	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.87	0.70	-4.43	177	8372	2012-10-03 04:39:14	2003-04-07 12:59:11	17	13	4320	108	2004	6434	2979	210.50	21	83.24	CHANGED	lGhl..sstushshh...ppl.........tphhsst.......................hlhhtssp.............hhptt.............................h..hhh..............pssptl.t.......tssc................................sllluCsos.shhtshp.....tt....thP...l.ls.hscss............ht........th.t......thp+...lullus..hsshtsthhpphlpp..G.....l........p..t.......th........shhp...hup.hsst...htthhpthp............ppss....-sllLu.CTphshh.phhpth..t..........h.......llDsspshsp....ts..h	...................................................................lGhh..Sshuslohh....cpl....................hc.hlsppp...................hl.hhtsss...........thP..........ppstpp......................................lhph.hh....................p.h.sp.tL.p........tssc.............................................hlllAC..N..Tu..p..s......s.s.h.thh........................pp.h..slP...............l..lu..lhpsu............................hc..................shtp......stsp+..........lull...uT......psTh...p.s..s...h...a...p...pt..lpph..s......l........................p..t..................th..hh............pls-.........tup..hpsp........shphltphlp................h.........ppss.............-sllLG.CT.chsll.hs....l..pphh.t............l.......llDostthsct..h.....................................................................	0	548	1190	1650
+69	PF01400	Astacin		Astacin (Peptidase family M12A)	Bateman A	anon	Swissprot	Domain	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3.  Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain.  All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin Swiss:P07584, a digestive enzyme from Crayfish. Meprin, Swiss:Q16819, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila Swiss:P25723.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.34	0.71	-4.91	26	2029	2012-10-03 04:41:15	2003-04-07 12:59:11	19	142	328	13	1290	1935	24	172.70	33	37.99	CHANGED	ppWsps......IPYhlssshsspp+shlppAhpcacppTCl+Fh.ps.......scsshlhhhpssGCh.ShVG+p..sGt.QslSlG.pGC..phGllsHElhHAlGFaHEpoRsDRDcalsI.apNI.sut.tsFpKhs.spssshGhsYDYsSlMHYsstuFSpss.hsTlhs+sst...hpssIGQRhphShhDlpplNphYpCss	.................................................................................................h..W.........lPYh.l....s.....s..p..........h........s..t...t...........p..p......t......h.l..hpAhppa...p.p......p......T......C.lc..Fh.ps.........................pppt....h..l.........h......h..............p......s.......s....G...C..h....S...h.l....G..............+............p.......s...........G............t........Q...t..l.....S......l............s.......t............s........C.................p........h.......G.............h.l....hHEl...hHulGFaHEpoR......s.......D......R......D.........p...a....Vp.I.......h...p........N...I.....................s.......s..h........p.......h................N...............F.......t.....c.......h..............p.....t....p.s........s...............s................h.........s.h.........s..........YD..asSl.....MH..Yu.t......h........s.............F.....o.......t.....s.......s.........................s........T.......Ihsh.s...........................ts.l.G...Q..R.....t.hSt..hDlh.......pls..thY.pC..t...................................................................................	0	532	658	1119
+70	PF02178	AT_hook		AT hook motif	SMART	anon	Alignment kindly provided by SMART	Motif	At hooks are DNA binding motifs with a preference for A/T rich regions.	14.50	0.10	14.50	4.00	14.40	-999999.99	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.40	0.75	-6.23	0.75	-3.59	40	2152	2009-11-26 15:21:48	2003-04-07 12:59:11	14	167	542	4	1233	2051	224	12.60	52	7.35	CHANGED	p+tRGRPpKstsp	...tRtRGRP+Kst..t....	6	380	638	979
+71	PF03029	ATP_bind_1	ATP-bind; 	Conserved hypothetical ATP binding protein	Griffiths-Jones SR	anon	Pfam-B_1301 (release 6.4) & Pfam-B_2154 (Release 8.0)	Family	Members of this family are found in a range of archaea and eukaryotes and have hypothesised ATP binding activity.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.56	0.70	-4.83	30	1967	2012-10-05 12:31:07	2003-04-07 12:59:11	12	16	660	9	1105	2459	404	206.90	26	79.02	CHANGED	VsGssGuGKTTassulschh.hpth...hlNLDPus..h.a.s.hslc-hlohsclhp-..hslGPNGulhhuh-...........................ahphsl...h...tccl...........................tt..s...hhLFDTPGQlEhathhsshs.hhp.h....phshssVhLlDopphsc...sssahushh.s..hhh.hplPalsslsKhDlhs.........h.hh.t........................hppLspslsphl-phshs.phhssuspsppuhpsLlshl-pthpt	............................................................lhGshGsG..........K..........TTas......t.slpp.hh..................h....p.......................................................................................................................................................................h....c..-......h.ls.h.t.slhp-..................hslu.s.p..u...u.h.h...hu.....h.-......................................................ahph...sl................pppl.....................................................................hh..LFss.....P...G...Q..h..............c......hah.h.h.s..s..hs..............................phsl.s..slh.L....l...D.o....p..p.h.s.s.........ss.cahss..h...............h...h..............hc.l.P.al.ss.lsKh...Dhhp...........................................................................................................................pthspsltthlp.h.....s..s.....hhs..s...t...p.p.t.pu.hptlhthlcps...h......................................................................................	0	386	688	948
+72	PF00306	ATP-synt_ab_C		ATP synthase alpha/beta chain, C terminal domain	Finn RD, Griffiths-Jones SR	anon	Pfam-B_15 (release 1.0)	Domain	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.85	0.71	-3.60	150	20853	2009-09-12 08:32:44	2003-04-07 12:59:11	22	34	11148	406	3509	16060	5135	103.40	33	21.66	CHANGED	tplusplpth....LtpacELpshsp....h..hG.-tL.u-pD.+h...h...Lp..+.uc+lcc.hLpQ....stassh...........s.................................lpc...plphh.....h.tllph..hpphs.pth.ttl........t............hpphcphtp	......................................csAppl+psLppY+ELp-lls........l..lGh......D-Lo-pD.+hp...lsRA++lpc.aLpQ...shassp.....s..t.phhs........................................................................lt-...slpsh.....h.tlhp..G...hD..pl....P.ppth..hhh.t..sh..s.......................tt.........................................................................................................	0	1226	2225	2960
+73	PF02874	ATP-synt_ab_N		ATP synthase alpha/beta family, beta-barrel domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes the ATP synthase alpha and beta subunits the ATP synthase associated with flagella.	20.90	19.00	20.90	19.00	20.80	18.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.90	0.72	-3.76	196	22044	2012-10-02 13:55:04	2003-04-07 12:59:11	18	33	11118	393	3707	16715	4934	65.20	30	14.01	CHANGED	lsplhGsVlslthst.s.hsslhsslplp..c...........tp.hh.h.uhshpLtsspVtslshssTsGlpc.GspVhsTG	..................................................p.hGsVlsV.......t.......s...........s......p.....h......sl..s..shtschhc.................................s..ss.h.tlt.pLtssp..Vtslshu.s..o..........cGlpc.G.pVhcTG..................	0	1311	2362	3125
+74	PF04718	ATP-synt_G	ATPsynth_g; 	Mitochondrial ATP synthase g subunit	Waterfield DI, Finn RD	anon	Pfam-B_5977 (release 7.5)	Family	The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport.  It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L). The function of subunit g is currently unknown.  The conserved region covers all but the very N-terminus of the member sequences. No prokaryotic members have been identified thus far [1].	25.00	25.00	26.40	26.20	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.28	0.72	-3.37	37	369	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	264	0	237	356	3	99.30	30	72.48	CHANGED	sscssphsst.slhau+stlphh+phh+sE.LsPP.s.uchpphhpshhphhp............hpsss......hh..hp..pls..hc-ushsulhusEllsaFhlGElIGR.RpllGYps	.................................................................h.thssthsst.slhau+...stlp.hhhhhh+sE..lsPP.osuch...phhpslhphhp.................hpsss............h+...pls.............sc-shhsul..husEllsWFhlGElIGR.tpllGYp...................	0	67	119	188
+75	PF03768	Attacin_N		Attacin, N-terminal region	Finn RD	anon	Pfam-B_2791 (release 7.0)	Family	This family includes attacin and sarcotoxin, but not  diptericin (which share similarity to the C-terminal region of attacin).  All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically  to kill the invading microorganism [1].	23.90	23.90	25.30	35.40	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.85	0.72	-4.10	17	105	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	32	0	30	120	0	66.10	44	30.45	CHANGED	htGolTsNscGuussss+lshs.sscshhsAlGuV.hsssp+....hussTtGlshs.NssGHGhSLo+o+	.......huGSlouNPsGGusAplclshs.lGssptsslGpVFAuuNop......uGPVTsGssluhNssGHGhSLT+TH..	0	7	9	20
+76	PF03797	Autotransporter		Autotransporter beta-domain	Bateman A	anon	[1]	Domain	Secretion of protein products occurs by a number of different pathways in bacteria.  One of these pathways known as the type V pathway was first described for the IgA1 protease [2]. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in.  The N terminus contains the variable passenger domain that is translocated across the membrane.  Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs [1].	22.00	20.80	22.00	20.80	21.90	20.70	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.69	0.70	-5.04	212	8209	2012-10-03 17:14:36	2003-04-07 12:59:11	14	136	1526	14	904	6497	851	238.90	16	26.88	CHANGED	sstpsshWspshushtp....pspsstsuhp......tphsGhtlGs-tth.......s.sshhlGhshuhspuphp....................s.stsupspspshtsuhYsph............................psshhlsuths..auhhcp.......thts..............tptpupapspshssplpsuaphth..........pshtlpPhsplpahtsptss..apEps.....t.hshpht.pshpslpsplGlchphpht..............................thpsh.hphshtap.hsstppsstss.....t......hsht..hscsshthpsGsphpls.pphsl.hhshs.....tptspss	..............................................................................................s...t.shWhphhusp.p........ts......s..s........thp...................tphtshpl..GhDhhh.................s.sph..hh..Gh.h.huhspsphp..............................ssttup.s.ps...pu...ht..huhYush...............................tsshalcsh..hp..hshh.pt..........t.ts...........................t.psph.p.u.pshsss..lcs..G.h.p.ath..............pshhlpP....s.p.l.pa....t..hpt.ss..ap-ss.......................s..hp.h.p..s.pshpshts....plG...hch.shp.hpht......................phpsh..hphshhpp...hssstp...ht...hss..............................shttt.hst.s..th..phthGh.ph..p.hs....pphsh..hhshs........h......ttt.................................................................................................	0	205	439	657
+77	PF03547	Mem_trans	Auxin_eff; 	Membrane transport protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs & Pfam-B_5261 (Release 7.5)	Family	This family includes auxin efflux carrier proteins and other transporter proteins from all domains of life.	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-11.80	0.70	-6.17	25	9093	2012-10-02 17:06:44	2003-04-07 12:59:11	13	27	3153	0	2760	7555	2542	180.00	10	85.92	CHANGED	sshpsll.lhllhllG.Yhus+h.plhss-pspslNchVhhhulPsLhFpplupssshphhhphhhhslhhhlhshlshhlsall.....s+.hh+hshchptslhshushsNssslGlPlLtulaGs...................tuhuhhlhhsslsslhhaolhh..................hlhp.putph.h.tt.s........................................................................................................................................................................................................................................................................................................................................................hhh.h..hhhh+hlhsPsshusllullhuhl.sahhsh.h..................phltpolslLusuulPhshhsLGlhLuhp.hhhshssthsth.........hhlRhllsPhlhlshshhhu..l.s..hhpshllp............sAhPsuhsshlhAppaslp.chsSsslhhuhllulhshslah	............................................................................................................................................................................................................................................................................................................................................................................h.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................................................................................................................................................	0	820	1729	2289
+78	PF02310	B12-binding		B12 binding domain	Bateman A, Mian N	anon	Pfam-B_359 (release 5.2)	Domain	This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2].	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.47	0.71	-4.24	133	8147	2009-01-15 18:05:59	2003-04-07 12:59:11	14	80	2972	71	3031	7333	2597	115.00	22	16.83	CHANGED	hpslhssstschaslGht.hlushlcp.t.Ga.........-Vh..hl.......shps...ps................................cpllp.tltph.ps-l..l.ul.....Ss..........hssshsth..tclhct......hcphtsplhlllGGshsshs.ph...t........hu.sshhhGpG.csshtslh	...................................................................................................s.phlhuphttDsHD.l.G....tp.ll....ush....l....ps....t...Ga............-.Vh......l.......s...h.hh.....ss.....................................................................................-cllc...tA.h.cp...ps-..l......l.Gl..........Sul.....................hss...s...h...s.t...h....hp.l.hct...............hcp..t....t....s....l.h..ll.lG.G.s.h..s...s....tsh.....t...................t.s...................h.......................................................	0	1180	2176	2679
+79	PF02607	B12-binding_2		B12 binding domain	Bateman A, Eberhardt R	anon	Bateman A	Domain	This B12 binding domain is found in methionine synthase EC:2.1.1.13 Swiss:Q99707, and other shorter proteins that bind to B12. This domain is always found to the N-terminus of Pfam:PF02310. The structure of this domain is known [1], it is a  4 helix bundle. Many of the conserved residues in this domain are involved in B12 binding, such as those in the MXXVG motif.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.39	0.72	-3.95	255	3838	2009-01-15 18:05:59	2003-04-07 12:59:11	12	34	2594	16	1269	3424	1047	78.30	34	9.66	CHANGED	ttphhpplhpullph-ppthpphlpp...........sl.p..........hsshpllpchlhsshpclGchap.psphhlsp.hhuuphhcpslshlhs	...........................................ltc+LppullcG.pchlppssc-..........................Ah.pp.s.........................hpPlclIpssLhsGMsh.VG-LFs..pGchFLPp..VlpSAcs.MKpAVuhLpP.............................	0	482	904	1109
+80	PF02362	B3		B3 DNA binding domain	Bashton M, Bateman A	anon	Pfam-B_582 (release 5.2)	Family	This is a family of plant transcription factors with various roles in development, the aligned region corresponds the B3 DNA binding domain as described in [1] this domain is found in VP1/AB13 transcription factors [2].  Some proteins also have a second AP2 DNA binding domain Pfam:PF00847 such as RAV1 Swiss:Q9ZWM9 [1]. DNA binding activity was demonstrated by [3].	30.10	30.10	30.10	30.10	29.90	30.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.41	0.72	-4.37	114	2169	2012-10-02 12:51:43	2003-04-07 12:59:11	16	44	101	2	1310	2264	0	98.00	24	23.90	CHANGED	Fhphh.....h.ssshpp.....shl...slPppF..sppp.........th..........tt.plhlps..pG............ppWphph.........pppspt.....hhls.......pGWppFspspsLp.sGDhlsFp..h..tt.psh..hlplhpts	..............................................Khh.h.oss.spt......s.th......slPcpaucph..........................t................tt..plh.h.cD..hpG.............ppWph+a...h.....................pspspp.......hhLs.......sGW.pp.FVpsppLt.sGD..sllFh......h....ps...pph..hltlh...s.........................	0	219	746	1021
+81	PF01313	Bac_export_3		Bacterial export proteins, family 3	Finn RD, Bateman A	anon	Pfam-B_898 (release 3.0)	Family	This family includes the following members;     FliQ, MopD, HrcS, Hrp, YopS and SpaQ All of these members export proteins, that do not possess signal  peptides, through the membrane.  Although the proteins that these exporters move may be different, the exporters are thought to  function in similar ways [1].	25.00	25.00	25.00	25.30	23.60	24.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.49	0.72	-4.30	202	3289	2012-10-03 02:46:00	2003-04-07 12:59:11	14	2	2171	0	652	1501	334	75.20	37	85.64	CHANGED	p.l..l...slsppAlhlslhluuPhllsuLlVGLllulhQAsTQIpEQTLoFlPKllulhlslhlhusWhhspl.hsaspp	.......t..llthsppAhhlsLhluuPhlllAlllGLllulhQAsTQIpEpTLoFlPKlluV.hlslhlhusWhhshLhsasp.t...........	0	203	390	513
+82	PF02673	BacA		Bacitracin resistance protein BacA	Mian N, Bateman A	anon	COG1968	Family	Bacitracin resistance protein (BacA) is a putative undecaprenol kinase. BacA confers resistance to bacitracin, probably by phosphorylation of undecaprenol [1].	20.80	20.80	20.90	20.90	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.61	0.70	-5.19	287	4568	2012-10-03 02:02:08	2003-04-07 12:59:11	13	2	3924	0	995	3043	2915	255.80	36	94.07	CHANGED	pAllLGllpGlTEFLPlSSoGHL.llssplluhp................s.uhsFslllQlGollAVllhFhcclhplhtshhpt...................................tptst+hhhhllluslP.ssllG.ll.hcchIc.....shh.t..shh..........h...luhsLllhGlllhhu-phspp......................hcshcplshpsAlhlGlsQslA.L.l.PGsSRSGuTIsuuLhlGhs.RcsAAcFSFlLulPshhuA..uhhclh....................c.hhp...........hss..s.sh....h.lhlGhls...uFlsuhlslchhlcalp+p...shhsFuhYRlllG....lll	................................................................................AllLGlVEGlTEFLPlSSTGHl.Il.s.s.c.l.lshp...............................shspsFpllIQLGulLAVllhahc+lhtlht.thhtt.........................................tptshphhhpllluhlPusl..l.G....ll.......hc..D..h..Ic............shh........ssh..................s..VuhsLllsG.llhlhs-...phppp.........................................................................thpslccloappAhhIGhh.Q.sLA.l.l.PGhSRSGuTIsGGllhGh.s.Rp.sAu-FSFhLul...PshhGA.ss.lclh.........................K..hhph..............hss....s...sh...........shh.hlGhlsAFlluhluI+hhlpalp+t....satsFuhYRlllGhl...............................	0	336	666	853
+83	PF01011	PQQ	Bacterial_PQQ;	PQQ enzyme repeat	Bateman A	anon	Pfam-B_1319 (release 3.0)	Repeat	The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilise pyrrolo-quinoline quinone as a prosthetic group.	20.30	20.10	20.30	20.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.89	0.73	-8.05	0.73	-4.17	130	3998	2012-10-05 17:30:42	2003-04-07 12:59:11	16	133	1153	135	877	8732	2893	36.40	26	10.04	CHANGED	sthhhs..shsGtlhAlDspT.GchhWphpsssss.stshs	................h.hh...shsu.lhAlDhpT..GchhWphphssss..................	0	220	462	667
+84	PF03704	BTAD	BAD; 	Bacterial transcriptional activator domain	Yeats C	anon	Yeats C	Family	Found in the DNRI/REDD/AFSR family of regulators. This region of AFSR (Swiss:P25941) along with the C terminal region is capable of independently directing actinorhodin production. This family contains TPR repeats.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.57	0.71	-3.89	64	2191	2012-10-11 20:00:58	2003-04-07 12:59:11	12	200	672	3	901	2383	154	140.00	25	19.33	CHANGED	lDlppFcch.sttGptshttG.c.tpAsptLppALuLW+GssLuslts......tshhpspst+LcEtRlpsh-tph-....scLpLG...Rtp..chlsELpsLlspaPh+EphatpLMhALaRsGRpu-ALpsYcclRptLs-ELGl.-PuspLppLpptlL	..................................................................hDh.tFtth...htt..u..thh..t.t....t....p............t.t.uh..th..h..pp..AL..s.........L.........a..+..G...s.s.Ls.s.hss....................h..h...p...s..t..t.t....p...L..c....c...h...pl..p....s..hc..p...hs..c.....ttl.thG..............ct.s......ps..ls.t..L.pp.lls........tcPh..c..EphhttLhtALh.psGR...p....uc...ALps.Ycch+phL...t.c.E.LGl.-.PusplptLhptlL....................................	0	399	719	858
+85	PF01426	BAH		BAH domain	Bateman A, Aravind L	anon	[2]	Domain	This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction [3].	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.87	0.71	-4.35	41	2185	2009-01-15 18:05:59	2003-04-07 12:59:11	13	109	308	34	1324	2175	2	128.50	19	14.46	CHANGED	tphplG-hVhlpsss....................................scs.....hhlsplhcl.......................................................................................................................................hpsssss.......thlc..spha..........hRPp-s....hhspthsp.......p..Elahosc...ptsh.hpslpu+CpVhhtsch.stp..h....................tsshF...aCchhYss.pptsFppls	...............................................................................................................h..hpl.G.DhVhl.psps.......................................................................sp.........h..lu..cIpcl.......................................................................................................................................hpsppsp................hh.hp...spWa...............................................h+Pc-s...............t.tcthtp..............................pElF.h...osp..........h-shs....h.s.s.l..h.GK..CpVhh.h..p..c.....h.pp.h...psht..................................................ppcsa...hhphhYs..pptth.....................................................................	0	367	643	1003
+86	PF01145	Band_7		SPFH domain / Band 7 family	Bateman A, Finn RD	anon	Bateman A	Family	This family has been called SPFH [1], Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.28	0.71	-4.37	120	13903	2012-10-01 22:02:33	2003-04-07 12:59:11	20	43	4514	5	4366	10740	5942	188.90	21	54.61	CHANGED	hhlss..................sphull...hp..hGchpp..............................shpsG....................hph.hhP....................hhpphh...hhshp.hpphphss................................................sshopDt...........hslsl...shsl.pa..+l..........................scshphhtph..............t.ps.......hpphlpshlpssl+shl....uphsh...p-lh.........ss.....................+.splspplppplp..........................................................pp.....................hpphG......................lp.lh..slp.lpclphsp...phtps...lppphtupppt......................ptphtpuctcs	..............................................................................................................hVtpsptull..........hp........hG+hpp..................................hh.psG....................................lph..hlP.................................hl..cplt......................hlshc...hpshchss..............................................................................................................................................psl.Tp...D.p................................ssl.p.l.......ss.s..l..ha....+l................................pcstph..hhsl.........................................................ps..............hc.p.t....lpp....h...spss...L....Rsll..............................Gph..sl.............-cll....................................................sp...........................................R.pp....ls.pp.l.pp.t..ls........................................................................................pp............................h..s..s...a..G.....................................lp..lh.....clp...l.p.......clp..sp..........plppu...............ht.pph.pAcppp......................pAthhpAcu..t.............................................................................................................................................................................................................................................................................	0	1454	2620	3579
+87	PF03594	BenE		Benzoate membrane transport protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.30	20.30	20.30	20.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.20	0.70	-5.91	9	1251	2012-10-03 01:44:59	2003-04-07 12:59:11	8	2	1036	0	255	994	220	346.90	45	93.78	CHANGED	sshs.SsllAG.hlAslluYuuslsIhapAA...psAtsossQhuSWlhululuhulsulhLShRa+sPlloAWSTPGsALLlouhsshslsEAlGAalVuuhLlhLsGlousFs+llppIPtulAuAMhAGILhtFulpshpAlsspPhLshsMlhsYLLsRpauPRYuVhhlLlsGlshuhhhGphphsslsh..clupPpalsPsFShtAhlsLALPLhLVuhsuQ.lPGhAlL+usGY.psPsuPllssTGLAShlsAPhGuholsLAAIoAAICpGP-AH.Dss+RYhAulhsGhFYllhGlFuuolluLFuuLPtsllshLAGLALLGulusuLttAhp--ppR-..........AAllTFllTASGhohlGlGuAFWGLlhGhlshhl	.......................................s.sslhAG.hlAlLlGYuS.ShsllaQAA...tsuG...AosuQluuWhhALuluMGloolh.Lo.l..hYRsPl.lsAWS.TP.....G...A...ALL...l.o..u..lt..G..h........o.....h.s....-AlGsF.l....lsssLlllsGloGhFsRLhp.h.IPtulA..uAMLAGI...LLp.............FGl..psFsu...lssp.s...L....shsMlhsaL.....l...s...+...th...s...P...R..Y..........A.....l.....lu.....s.h.....lh.....Gl...s.....l...s....h..h.....t....G...p.l..s..h...s.s......l.t.h.....ph.s...hP..sa..l...sPpFS.hushlul.A.l.............PLFlVTMASQNhPGlAsh+AsGY.....p..........sPsuPllshTGLhuLlhuPFGsaulslAAITAA.IC.tus-AH.D.scRahAuhssGlFYllsGlFGuslsulhsALPhshlthLAGLALLuoIuuuLhpAh.p..s..p.cpR-..........AAllsFLVTASGloLhGIGSAFWGLluGhlshh..................................................................................................	0	54	114	193
+88	PF02944	BESS		BESS motif	Bateman A	anon	Bateman A	Motif	The BESS motif is named after the proteins in which it is found (BEAF [2], Suvar(3)7 [3] and Stonewall [1]). The motif is 40 amino acid residues long and is composed of two predicted alpha helices. Based on the protein in which it is found and the presence of conserved positively charged residues it is predicted to be a DNA binding domain. This domain appears to be specific to drosophila.	20.80	20.80	20.80	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.34	0.72	-4.37	43	441	2009-01-15 18:05:59	2003-04-07 12:59:11	15	14	44	0	223	465	0	36.70	27	9.80	CHANGED	pDsDp.hFLhSlhPtl+pLsspp+hch+hclhpllhch	.....ssDp.hFLhSlhPhl+pLss.pp+hch+hclhpllh-......	0	53	68	167
+89	PF02369	Big_1		Bacterial Ig-like domain (group 1)	Bateman A	anon	Bateman A	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity. 	30.40	30.40	30.40	30.40	30.30	30.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.43	0.72	-4.10	20	5706	2012-10-03 16:25:20	2003-04-07 12:59:11	11	124	515	5	385	5116	64	96.30	26	34.44	CHANGED	hls..phpAsloplh.......Asss-ssTlTAoVpDtsGsPlssppVoF.....ssstssLsss.....shTcssGhAploLouo......psGstsVoAols.sssss.pspsV	.................................s.....tuph.s......h.h...t....hhA..s...sss.s.so.lpA..sVp.D...s...p.G...N.s.l..s..s..t.sVsF............ssssss...ls.s.s......................spTss.sGh.A.p..l.o..l....o.u.s.........p.s..G.s..hs.V.oAo.ls..ssssp.p..................................	0	82	201	296
+90	PF02785	Biotin_carb_C		Biotin carboxylase C-terminal domain	Griffiths-Jones SR	anon	ref [1]	Domain	Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step  in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are in  this C-terminal domain.	20.70	20.70	20.70	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.09	0.72	-4.06	109	10242	2009-01-15 18:05:59	2003-04-07 12:59:11	14	97	4650	113	3077	8078	3751	106.20	38	14.54	CHANGED	EsRlhAE..DPtps.....F.hPus.G.plsthp.h...............P............susulRlDou.ltp.....Gs.plssaYDsMlAKlIsa..ussRppAlp+hppAL.schp..ltG..lpTNlsaLppllppspFtsu.....phsTsal-	................................................EsRIsAE......DPtps.........F..hPus.G.......c.l.p..php..h...................................P.........................uG..GV...RlDou..l..h.s................Gh..slsPaYDSMluK.l...............Is..a......G.p..s.....Rpp.Alt+hppAL..p.E..h..h.............l..c.....G.......l......p......T.Nlsahh.p.llps..sF.tsG.........shsTpal-.......................	0	942	1879	2586
+91	PF02012	BNR		BNR/Asp-box repeat	Bateman A	anon	Bateman A	Repeat	Members of this family contain multiple BNR (bacterial neuraminidase repeat) repeats or Asp-boxes. The repeats are short, however the repeats are never found closer than 40 residues together suggesting that the repeat is structurally longer. These repeats are found in many glycosyl hydrolases as well as other extracellular proteins of unknown function.	23.00	12.80	23.00	12.80	22.90	12.70	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.75	0.76	-6.08	0.76	-3.20	188	830	2012-10-02 00:45:24	2003-04-07 12:59:11	15	46	547	34	224	1738	836	12.00	57	2.20	CHANGED	hhSpDsGpTWpt	...hSsDsG+TWp...	0	106	173	212
+92	PF00528	BPD_transp_1	BPD_transp; 	Binding-protein-dependent transport system inner membrane component	Bateman A	anon	LMB bacterial genome group and Prosite	Family	The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.97	0.71	-4.78	81	156339	2012-10-03 05:18:07	2003-04-07 12:59:11	17	117	4892	36	36523	106567	36248	195.90	15	65.39	CHANGED	ulhlGhhsu...hhhsphhcphlhshh.hhh.....slPshh.......lhhl......lh..............................................shht.tshhs.h..lhlhhhhhsshshhhptthlp.tlspshhcsucshGhsphphlhphhlPsuhsslhsshhhshsts.ltssshhphlhs.........lGhhhhpuhhshshs.h.................................hhhhhhslhhlllsllhshlhphls.+hpt	............................................................................................................................................................................................h.hGh.hhu.................h..ht..h....h....h....p..t....h...h...t...h...h...h........l...h.h.........s.l..P..sll............................h.hhh.................h.h.hh.....................................................................................................................................................................................................................h.t.h.ht....h.....s...h...h...s....s..........l..l...s....h....s....h....h...h......h.......s......h......h.......h...h......h....h..t....s....s....l.p....s....l...s..p...s....h.......h-..A............A.p.s.....h.G.s.............s.p....h.p.hh.h.clh..L.P...t..s...h....s...s...l.l....s...s.h...h...h.s.h...s......t...s....l...s......s......h....s...h...s...t......h......l........s......................................h.s.t...h...h....h....t.....s.......h.....h.....t....h....t...h.s.hh.......................................................h.hh.h.s..h.s..l.h...h...l...l...l..s.h.l..h...h.h....t.h.h......t............................................................................................................................................	0	10630	22134	29422
+93	PF02237	BPL_C		Biotin protein ligase C terminal domain	Bateman A	anon	Bateman A	Domain	The function of this structural domain is unknown.  It is found to the C terminus of the biotin protein ligase catalytic domain Pfam:PF01317. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.15	0.72	-4.27	50	3072	2012-10-01 19:11:18	2003-04-07 12:59:11	12	11	2996	75	760	2212	402	47.40	30	14.56	CHANGED	hlGcpVplpt..tstpl..pGhspuI.DcpGtLllctssu.............hctlhuG-l.ht	...................lG+tVplhh.....ssppl.....pGlupuI.DcpGtLllcpssG.......................hp.s.lhuG-lsl................	0	221	459	621
+94	PF03099	BPL_LplA_LipB	BPL_LipA_LipB; 	Biotin/lipoate A/B protein ligase family	Bateman A, Reche P	anon	Reche P	Domain	This family includes biotin protein ligase, lipoate-protein ligase A and B.  Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites.  Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organism probably has only one BPL.  Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine [2]. Lipoate-protein ligase A (LPLA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes [3]. The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor [5].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.78	0.71	-4.11	66	11826	2012-10-02 14:22:40	2003-04-07 12:59:11	14	48	4791	113	3031	8364	4175	120.70	19	40.71	CHANGED	huppt.sst............hthpthppsslhlsccpouGp.....tsacs.hu.slhaollht.t....p...h..h..shthshssh.csL.....................t..s..h......h.sDlhh............ss+Kl..uGlhhch......pt...ttthpthslslshs	................................................................................thh...p.p...s.....s...l......l.......s..c.p..p..o..G....Gp..............ts.a...p..s..............ts...s...lhhol.....l.....h......h......t.......p...t.......................................htth...........shhht.h.shl..csL.........................................................t..u.s.p.sp.......hp..h.N.D...l..hl.........................................ss.+.Kl......uGlhhch................pp......sst.hp....t..h.s.lslshs........................................................	0	1020	1916	2578
+95	PF02485	Branch		Core-2/I-Branching enzyme	Mian N, Bateman A	anon	Pfam-B_842 (release 5.4)	Family	This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme (eg Swiss:Q06430) and core-2 branching enzyme (eg Swiss:Q02742). I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development [1]. Core-2 branching enzyme forms crucial side-chain branches in  O-glycans [2].	23.40	23.40	24.30	23.50	23.10	22.30	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-5.22	47	1645	2009-01-15 18:05:59	2003-04-07 12:59:11	16	15	375	10	869	1568	50	236.40	20	55.03	CHANGED	lAFhals.+GsLPhh.lW-pFhp...sH.cs..haslYlHsp.ss.hpp.h.t........sshF.sR.Is.SptVsaGphohlsA-++LLAsALh.D..sNchFlLLSpSClPLhsFsplapalhps..spSFl-shspss.ttp.sRas.p......hhP..clphp...............caRKGSQWhtlsRphAhhl..l..tDshhashFppaC...................................ssChsDEHYhsTl.........lshh..hsstssNpol.......TalcWs........pttsHPtpat....hpslo.chlpplp	......................................................lAahhhs..p...s....h.hh....hhhphh.....h....t...............pshas.lalDtc....s..t.ht.p.th.t......................ps.h.....s.s..h.h..h...s.......p..........t..l..ha..ush.ohlpAphphh..........tsh..........L.....p......................s......h.....s......h....caal.L.SusD..hPlpo.p...p...........l.h...phl..........p.....t...........................t......p...p.................s.....h..h...p..p..h...p......t..s............s...h.h...........h.p....t+....hp.h.............hh......hthp.................................................................thphhtG....S.t............Wh..sLo.....Rpas....pal...l..........pD..ph...hhphh...phhp....................................psh.h..s...-Epa..atTl........................lp.....t........ht.....p.....s..h....h...s.ps.l.............................phh...pWs.............................tph.......t.hs.t.h....h....................................................................................................................	0	213	446	651
+96	PF00533	BRCT		BRCA1 C Terminus (BRCT) domain	Bateman A	anon	[3]	Family	The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage.  The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs [2]. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilised head-to-tail BRCT-BRCT oligomerisation mode [3]. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants [5].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.45	0.72	-3.83	114	8489	2012-10-02 11:51:29	2003-04-07 12:59:11	21	297	4740	142	3410	8863	1950	78.30	25	11.50	CHANGED	tttphhpshphhl.......tthpphp+ppl...pphlpphGupl.........................tsph.sppssall....ssps...................tt.tc.............httshphshtlls.pWlhcsl	.............................................................................................s.....htGhshll...........sush.p..p..h.s.R..s.ch..............cph.l.p.p.h.G.u.+l................................................................................ssol....o...c.c...T..s...a.ll..............sGcs................................................su..sK.......................................ht.cA..p........p....h....G......l...p....l..l.s-p.hhp.............................................................................................	0	1124	1906	2771
+97	PF04089	BRICHOS		BRICHOS domain	Sanchez-Pulido L	anon	Sanchez-Pulido L	Domain	The BRICHOS domain is about 100 amino acids long. It is found in a variety of proteins implicated in dementia, respiratory distress and cancer. Its exact function is unknown; roles that have been proposed for it include (a) in targeting of the protein to the secretory pathway, (b) intramolecular chaperone-like function, and (c) assisting the specialised intracellular protease processing system [1]. This C-terminal domain is embedded in the endoplasmic reticulum lumen, and binds to the N-terminal, transmembrane, SP_C, Pfam:PF08999, provided that it is in non-helical conformation. Thus the Brichos domain of proSP-C is a chaperone that induces alpha-helix formation of an aggregation-prone TM region [2].	21.10	21.10	21.10	21.30	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.12	0.72	-4.12	40	591	2009-09-14 09:13:14	2003-04-07 12:59:11	9	13	95	6	287	508	1	93.50	25	36.19	CHANGED	huuucsushlaDappslsAh+shstppCYlhphspstlPshpsLtchhhph......ptpsth.ssphhcpphh.....sspplpDhshLG.tI.tpLCtshPhYhl	.....................ssucsushl.aDFp..ps..loAhhs.h.......shp.......pCalhthsps.hl.s.cslhchhhph...................pttshh.p..ohh..hpcphh.....sspplp-...h...s..L.G...hI.hpL..CpshshYhh.......................	0	42	57	123
+98	PF04427	Brix		Brix domain	Bateman A	anon	Dlakic M	Domain	\N	28.10	28.10	28.30	28.30	27.70	28.00	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.40	0.71	-4.64	149	1923	2010-01-08 13:34:18	2003-04-07 12:59:11	13	24	441	1	1305	1849	23	196.60	24	58.96	CHANGED	l..hsu................p...psspphpphhcDLpplh..Psup........phs+tp......h.php......chhchst.ps....ssslllh..pppct.psstlhls+h.....spGPoh....pFp............l......ps...hphhc-l..........t...............Phllhsshtsp....................hphlpphhpshFss........hs..t.......phc+llshp.t.....................p.........pch................................IhhRpa.h...............................p........................................................................................................hpLpElGPRh.slc...........lhcl	................................................hpup..pss.tphpphhp-lpt.....lh...Psup.....php+tp...................t..plp....................phl.phsp.ps....soslllh..............pp....p..cp.....p....s.......ss......L......hls+h........PpG.Poh........pFpl......pshphhc.-.lhtthptsh.....spp..................................................PhLlhsshtsp........................hphltp.hh.tp.lFss...........sh.............thc+Vlshs.t...................p...cch.................................................................I.hRpa.h.......hhp.............p..............p.................................................................................................................................................................hpLtElGPRhslplhc...........................................................................................................................	0	469	738	1083
+99	PF03097	BRO1		BRO1-like domain	Bateman A, Kim J, Mistry J	anon	Bateman A	Domain	This domain is found in a number proteins including Rhophilin Swiss:Q61085 and BRO1 Swiss:P48582.  It is known to have a role in endosomal targeting.  ESCRT-III subunit Snf7 binds to a conserved hydrophobic patch in the BRO1 domain that is required for protein complex formation and for the protein-sorting function of BRO1 [2].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.12	0.70	-5.71	70	1087	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	297	31	739	1088	8	341.70	21	47.18	CHANGED	shlslshKcop..pl-..hspsLppaIpppY...spsssh...a.....pcclpplspLR....pshhs.........psstsulch........................LhcYaspLphLpt+h..P....sppht.l...........pFsW.aDuh...........................tpst......shspps..ltaE+uslLFNluAlaoplAspp..........sp...p.ss-GlKpAsshFQpAAGsF....palp-s...........hhpsPoh....D..lstpsLpsLtpLhL..........................AQAQEshhtKslt...s................shcsullAK.......LuspsuphYpps.........hpshppsshtt...............................................hp........tpWhshlphKtta......apAlApYatuhsh.....................................pppppaGct.......l...................................Ac...............................LptAhptlp-Ahphtth...................ttttlhpslpthpsplppcLpptp+D.........NDhIYhp.lPs.ssls...slt.shshs+sl.shsp.h............pt.p...ssclFppLlPhsltput......ohas-cpsphlppph	............................................................................................................................................+....s......hp..h.....h.thl.t.h...tp...................h............tpth.t.thtt.hR....................pthht............t...thhph...................................lh.pYhs..L.hl....t..+h.....s..............tpp.t...l.............................................Fp.W...hssh..............................................................ptt.................hs.ps.....ltaEhsslLaNluulhophus.pt................................sp.....s..sp.p...u.h....+.t.A...hphap....p......A.A..Gha........palpcp..............................................h..psss.......D.....hs.pslp....sL.plhL................................................................A.QAQE..shh.tKsht.......p...........................phpssl......lA.+.......lus...ps...sphYppu..........hpt.hp..p.....s..s..t..t..................................................................................................................h.........ppWhthl........phKtth......atAhAph..atuhth......................................ppppph...Gptl...........................................................up...............................L.ptA.phhp.puht.tt.............................................t...h.t.hpthh....ptlp...p.phpphp+-.........N-hlY.h.p.lPs......t.h...................ht...h.hst..sh......................................a..thhP.th....t.ht...........h........................................................................................................................................................................................	0	248	387	590
+100	PF00439	Bromodomain	bromodomain; 	Bromodomain	Finn RD	anon	Prosite	Domain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.74	0.72	-4.06	69	7921	2009-01-15 18:05:59	2003-04-07 12:59:11	20	370	355	282	4778	7646	90	84.20	26	10.39	CHANGED	hpplh........p...phhppt...st.F.t.......stpthssYhp.......hl...ppPhsLspIpp.......+l...csspYp...s...................................h..tpahpDhphlhpNuhpa........st.tss.hhp....tupp	................................................................h...........h.ppp........huh...s...FhpPV........................stp..p..h..P..-.Y.a.c.........................lI............+p.PM....DLs.Tl.c.c..................................+l...............cs..p....p....Y.p.......s............................................................................................................................h...pca.h..........p.....Dh.pL.......hhpNshtY.............Nt..sso.lhp.u..h.............................	0	1623	2367	3612
+101	PF03909	BSD		BSD domain  	Yeats C	anon	[1]	Domain	This domain contains a distinctive -FW- motif. It is found in a family  of eukaryotic transcription factors as well as a set of proteins of unknown function.	20.40	20.40	20.70	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.85	0.72	-4.23	81	1184	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	308	4	822	1161	12	60.20	21	16.77	CHANGED	hst.ppph.sh...t.p........tcphpplLppsss.LpphhpchV.......PptlscppFWppYFhththhptptspp	....................................s......ph.ph...p.p........hc.hppllppsPt...lpphatchV............Pptls.c....p.p....FWpp.aFhthhhht.ptt................	0	250	448	674
+102	PF03092	BT1		BT1 family	Mifsud W	anon	Pfam-B_1804 (release 6.4)	Family	Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants [1], thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member  of this family) was previously noted [2]. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted  prokaryotic proteins (from the cyanobacteria Synechocystis and  Synechococcus).	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	433	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.50	0.70	-5.77	12	726	2012-10-03 03:33:39	2003-04-07 12:59:11	11	11	173	0	486	924	508	341.70	21	71.34	CHANGED	pGlus.lhphss.hhhp-chGlssuthQtLsslushsWslKshhuhlsDs.ashhGYp+R.YhhlSslhG.h.uhhauLLsuh.sSsshAuhhlhLuohuhA.sDlls-uhhschhRppPps..usuh.ShhWhh.hlGullushhsGsLs-thtsphshhloAsl.hlshl..................suhhlhcp..........................................................................................Eshthscs...sphhs.....+cslsp.W+hhhh.............ssIhtssL..............hhshashslslspA...................hFYhsTspht.....FohpFhspVt.llGsluuLlGVslasthhpphsaRhhhhloslhpsluulhDlIlVc+hNhhlGIsDa.hallGDullhplshhltaMPhlVLhuRLCPpG.EuslaALlhuhhsLGpssSutLGulLhcahh...hTpss.....asNLshLlllsslss.LlslPLshLL.s.t...c.hDtsschspcts	........................................................................................................................................................................................................................................h..hsh..hhpp.hthp..ss..t.hth.....ht..shh.t.h.PWs.h.Ks...hhGh.loDs..h..s..l..h.G.a...+.....R+sY.h.h.l..u....t...hl...s.......h....h.........h..h............h.u..h..h...............s......t..............................................h.............................h......h......h..........h..h....h...h......s......h....s..hs..........h.....-.....l.h.-..uh...h..s.......p.......................t...............s..................................t............s............t............h.........................o...hh......h.h.........h...u.s..l.....h..........s............h.h.....s..........G........h.......h.......p.................h.......................p..................h.......h..h............hh...h.h...h............................................h...h........................................................................................................................................................................................................................................h.t...hthh.....................................................lh.shh........................................hh.h.h...h.........ts...........................................h..ah..t....h..............h.s...............hhs......hht..hhs.......thh.hhuhhhap...h..h.....t..p...........h...s....h..+.............h..h....h....h..t.h.h.....h...h..h.h.h.........l......t...h.s.....h........h............ls....st..hah.hh..t.hl.....phh..hthhPhhhh.........sphsP...u......E..ushauhhhuh.shu..h.ut.hu.h.l.thh..............hstt................aptl.hhlhht.h....hhsl.h......hl..........................tt..................................................................................................................................................................................................................................................................................................................................................................................	0	200	338	460
+103	PF00651	BTB		BTB/POZ domain	Bateman A, Bardwell VJ	anon	Prosite	Domain	The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer.  The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.48	0.72	-4.08	96	15670	2012-10-02 01:20:04	2003-04-07 12:59:11	26	989	511	79	10101	15120	88	105.10	20	20.57	CHANGED	hsp.pppt...hsDlslhlt.......pphpuH+slLuupSsYFpshFpsp.................tpts...........l.hpslssp..shptlLcah..Ysupl.h.............tpsltplLphA.phhpltslhptCpphlhpph	..............................................................h.pt....hs.D..ls.l..hlt...................tpph....sH......+...........s................l...............L...u....u...p.......S.s......a..F.....c..s...h..hpss........................................tcpp...........................tlp.l......p...s.......l......s.......s..p...........s...hp...t.l.....L..c...a..h.......Y...o....u...p...l.phs..................................tps....l...........p....l...l......t...s...A...p....hh......p..l......t..t..l.hphstphh....h.....................................................................	0	2968	4235	7306
+104	PF03437	BtpA		BtpA family	Finn RD	anon	Pfam-B_4453 (release 6.6)	Family	The BtpA protein is tightly associated with the thylakoid membranes, where it stabilises the reaction centre proteins of photosystem I.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.39	0.70	-5.13	6	562	2012-10-03 05:58:16	2003-04-07 12:59:11	10	3	505	0	178	689	382	246.50	36	93.56	CHANGED	pcKPlIGVVHLhPLPGSspasu...........sLstVID+Alp-Apslp-uGhDAlIlENaGDtPa.Kp.Vs.tTVuAMolIssclpp-VulPlGINVLRNDuluAhuIAhulsAcFIRVNlLoGsthoDpGIlEGsAtELh+h++hL....su+.lclLADVtVKHAhahus..lpsslhDTlER..uhADAVIloGpsTGucsDl--LchAKcsss...sPVllGSGVs.cNlpphhphADGhIlGThlK+sGph.N.lDh-Rspplschscc	...............................................................................................................................pKslI.uMlHLpsLPGsPtass...........shptll-+Ahc-htsLpsGGVDulhhpN.ashP.a.h..p..c.....l.t.scssuuMuhl...htpl..tp.p.l..p........l.P.....h.....GVNVLh.DshuuhslAhAssA.cFIR......p.ha.sG.sas.uD....Glh.-.sssu-hlRa...p+pl....s.As.pl+llh.slhsctu..sh..L...u..s........c..s..l..........s..p.h.s+.s.sh.p...stsDAlh...Vo...G...hs.sG..s....p....s....s.........t...........L....c....p.l..+csss..........tsPVl.ssoGV.s.h.-.N..l.pc...L.s.h..ADGsl...luos.h....Kc....c...G.hhtN.....................V...D.tRVppFMctlp.p...........................	0	60	104	151
+105	PF03131	bZIP_Maf		bZIP Maf transcription factor	Mifsud W, Eberhardt R	anon	Pfam-B_482 (release 6.5)	Family	Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.04	0.72	-3.69	15	969	2012-10-02 13:17:30	2003-04-07 12:59:11	12	8	158	8	512	2370	5	91.10	34	20.20	CHANGED	hSD-cLlohoVRELNRpL...+GhocEElh+LKQ+RRTLKNRGYApsCRhKRlpQ+csLcpc+scLppplcpLppEhuthppEpDulpt+hptLt	.......................................os-pllshsVc-h...NchL........ctLo..c-plthl.....+.p....hR...Rp..h...KNR..shAQs....CRp++l...pphppLE....p...-h.pp.......L.ppc.h-cLh.p.Ep....s.p.h.tp.phcth+p+hpth.h................................	0	105	151	298
+106	PF00168	C2		C2 domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.90	4.50	20.90	6.10	20.80	-999999.99	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.89	0.72	-4.14	382	23398	2012-10-10 12:23:49	2003-04-07 12:59:11	25	644	543	119	13594	21474	315	86.10	20	17.18	CHANGED	LplplhpApsL.shc..........................................hps..psDPYVplplts.......tp...........................h+Tcshcps..hNPhWs.....Epatap..h..sphpp......LplpVh.Dpcthst...............cchlGpsp	............................................................................................................................................ltlhpu....p...sL.....s.h.s....................................................................................hts....ts..D....P...a.l.p..l..p..lt.s...........pp......................................................................................t+T......c...s.....h....p.....p....s.....h.........s..P..h....as..............-.p..h..t.ap...h.............t.p.hpp.......................Lp.l.p...Vh....D..t..c.t.htt...................schlGph.t...............................................................	0	3560	5729	9404
+108	PF02743	Cache_1	Cache; 	Cache domain	Bateman A	anon	[1]	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.49	0.72	-4.42	19	6574	2012-10-01 23:40:40	2003-04-07 12:59:11	13	246	1855	16	2046	5858	159	78.30	20	11.74	CHANGED	lT-PYh-ss...........ssphVlThuhPlhs............ttphhGVluhDlslcsLhphhpplplGtpGYsFllstsGpllsHPspcshscpttt.	............................................................otsYh..s.t............................st..p..h..h..l..oh..u..t..P.l..hs.....................................................s.u.p.h..h...G...V....l..u....h....D..l....s....l....s........p....l....t...p....h....l...p....p.....h.......p..........h......s...p..s....G....a.s....h.l...l..s.....p.....s.....G.p..ll.s...+..sp.p.........h................................	1	687	1216	1644
+109	PF04857	CAF1		CAF1 family ribonuclease	Bateman A	anon	Pfam-B_1567 (release 7.5)	Family	The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 Swiss:P39008 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localises to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain Pfam:PF01424. This family of proteins is related to other exonucleases Pfam:PF00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 (Swiss:P39008) has been resolved at 2.3 Angstrom…resolution [3].	23.50	23.50	23.60	24.00	23.30	23.10	hmmbuild  -o /dev/null --hand HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.68	0.70	-5.06	27	1134	2012-10-03 01:22:09	2003-04-07 12:59:11	15	22	328	16	721	1069	11	271.30	26	67.58	CHANGED	pcVWppNhpcphphlpphlcphs...alAhDTEFsGllscshtp......htsss-.pYptL+pNVsthpllQlGLohh.....sppuphss..........shs.........................sapaNFp.Fshcp........chh.stcSIchLpppGhDFpcppcpGlshtphs.......................................................................................................................................................................................................................................................................................................phlhsSsllhst.p..lpWlsapusYDhuaLl+llp.s......tpLPppht-FhphlpthF.Pp....lYDlKhlhp..h..........................................................................hp...................ph....uLpclA-tLplpR.......................................................................................................sGp.tHpAGuDoLlTstsFhc	...................................................................................................................................................................................................-VhtpNhppp.hthlpp..h.l..p..phs....alAh........Ds.EFs..Gls....s..p..shst................htsss-.p.Y.p...t.l+p..s....s.c..hh.pl..lQlGlohh...............sppsphs..........t.hs...................................................................................sapFN.Fp...Fshpp.........................chh..stsSlph.Lt......p......p......G.h....s......Fpch..pp..G..Ishhphs..................................................................................................................................................................................................................................................................................................................phh.h..h.Ss.l..l.ht.......p.....h.h.h.lsa..p..uhhDh.salh+hhhs..............sLPps...t.pFhphl...phhF..Pt..........laDhKalhp..t......................................................................................................................................................................t.psuL.pplt..c.t.L.thpp...........................................................................................................................................................................................................................................s....HpAG.DuhhTu.sah........................................................................................................................................	0	236	379	557
+110	PF03135	CagE_TrbE_VirB		CagE, TrbE, VirB family, component of type IV transporter system	Mifsud W	anon	Pfam-B_843 (release 6.5)	Family	This family includes the Helicobacter pylori protein CagE  Swiss:Q48252, which together with other proteins from the cag pathogenicity island (PAI), encodes a type IV transporter secretion system.  The precise role of CagE is not known, but studies in animal models have shown that it is essential for pathogenesis in Helicobacter pylori induced gastritis and peptic ulceration [1]. Indeed, the expression of the cag PAI has been shown to be essential for stimulating human gastric epithelial cell apoptosis in vitro [2]. Similar type IV transport systems are also found in other bacteria. This family includes the TrbE Swiss:P54910 and VirB Swiss:P05353  proteins from the respective trb and Vir conjugal transfer systems in Agrobacterium tumefaciens. Homologues of VirB proteins from other species are also members of this family, e.g. VirB from Brucella suis Swiss:Q9RPY1.	20.50	20.50	20.60	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.95	0.71	-4.56	15	1506	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	797	0	316	1404	70	190.30	20	25.11	CHANGED	phLuphpp.psltas-lLpFhsphls.Gppp.shtlsps..hlDshls......uplhhscct...........hhhcpssp....ppasuhlul+-Y.sscopsshlsslLptchEhllhpoFshhs+ppupshlp...ppphhstscputspltclsptlcphsusphshGhap.olhlaAcshppLccpstcspstLpspGhlustEoluh-suaaupLPuNhphpsR	.....................................................................................................t.........pth.hsc.hpahphhls..sp.p...lhhspt....lsthls.......sphh..hstcp...............h...h.p..t.t.t......................ppasshl.s.lp....p.Y.s.phpsshhsh.hh......t........h.........s......h...p...hhhhpsa....p...hhs.......ppp....s..................hsh....lp...t....................p.............p...p.....................hh..............p....h....................s.................s.....s...u....ts...p......h....................t.-.hs.p......ul..p..p.lss..sph.s.h.G.a....pholh............lh..............u.......c....s............h....c.....plcppspts.t.sh.l...p.s...t.G....hhs..h.h-..sls.h.s..u..aauplPuphhhp.R......................................	0	58	171	237
+111	PF02515	CoA_transf_3	CAIB-BAIF;	CoA-transferase family III	Mian N, Bateman A, Heider J	anon	Pfam-B_887 (release 5.4)	Family	CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.	20.70	20.70	20.70	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.21	0.71	-5.06	118	8297	2009-01-15 18:05:59	2003-04-07 12:59:11	12	30	2042	90	3017	7416	4895	185.50	29	47.03	CHANGED	lsLDL+sspG+tlhpcLlp....pADVllcNh+PGshc+lGLsh...csLc....phN.....PcLlhsuloGaG.p....sG..Phss..psuaDh.shpAhoGl.....hsh.s..........sss.s...P.hhsuhs..lsDhsu.uhhuuh...ulLAALh....pRp..c.oGp..Gph....l-lohh-s.shth.hs.hhhthhts.s.th.t..........Gstp...........sssssh..shaps....tDG.......alsl..u.shssphWpth	.................................................lsLDL+..s..scGpphht.cLl.t..............pA....D....Vll..EN..a+....P.G..sh.....c.+..h.Glsh......-.s.Lp......th..N.........P.+....Lla..ss.l.o.GaG..p............s.G.....P.h.ss....p.s..u......a.............Dh.l.h..p.A.h.uGh...........................hsh..s........G...........................ss....s...............P...h.....h.su...ss...........lu.D...hss.G.h.h.ush...ulL.u....ALh..............pRp......c......o........G.....c..............G.....ph..............lDsuhh-s...shs..h........h.t............h..h..h....t...h..h..t..s..u....t.st................t.h.................uttp.........................sshssh...ssaps...............tD..G...............hlhl..u...shpst..at..............................................................................	0	656	1710	2447
+112	PF02888	CaMBD		Calmodulin binding domain	Bateman A	anon	Psi-blast P70604/413-489	Family	Small-conductance Ca2+-activated K+ channels (SK channels) are independent of voltage and gated solely by intracellular Ca2+. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the Ca2+-binding protein calmodulin (CaM) [1]. CaM binds to the SK channel through this the CaM-binding domain (CaMBD), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when Ca2+ binds the EF hands in the N-lobe of CaM. The structure of this domain complexed with CaM is known [1]. This domain forms an elongated dimer with a CaM molecule bound at each end; each CaM wraps around three alpha-helices, two from one CaMBD subunit and one from the other.	25.00	25.00	28.80	28.10	23.70	22.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.63	0.72	-4.17	5	334	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	83	7	163	297	0	74.40	61	13.92	CHANGED	DoQLTKEhKNAAAsVLQETWhIY....KHT+h.p+t-ppRlRKHQRKFLpAIHp...FRoVKhEpRKlsEQsNohsDluKs+pl	............DTQLTKR.lK.NAAANVLRETWLIY....KaT+Ll.......KKhDpu+VR+HQRKFLpA.I..Hp........LRpVKh-QRKLsDQANTLVDluKhQsl....................	0	31	45	98
+113	PF01302	CAP_GLY		CAP-Gly domain	Bateman A, Finn RD	anon	Prosite	Domain	Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein Swiss:Q20728 CAP-Gly domain was recently solved [2]. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove [2].	24.90	24.90	25.10	24.90	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.56	0.72	-4.27	146	2400	2009-09-10 15:43:18	2003-04-07 12:59:11	20	120	319	45	1448	2206	31	68.20	38	10.48	CHANGED	lG.pRl.pl...........tstthGsl+a......lG.psp.hss............................G.............h......WlGlEh.Dp....s....h.....GK....NDGo..l.pGh+YF..pC........p.sp.....tGhFl+spplp	...................................lGsRV.l............ssschGsl+a......lG...tsp.hss....................................G................h......WsGVEL..Dc.....P....t.............GK...................NDGo........V......p.........G......h+....YF..pC...........p..sp......tGlFspss+l.p..............................	0	487	694	1078
+114	PF01039	Carboxyl_trans		Carboxyl transferase domain	Finn RD, Bateman A	anon	Pfam-B_299 (release 3.0)	Family	All of the members in this family are biotin dependent carboxylases.  The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognised types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide.  All of the members in this family utilise acyl-CoA as the acceptor molecule.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	493	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.40	0.70	-6.15	34	11662	2012-10-02 13:07:06	2003-04-07 12:59:11	17	72	5959	146	2951	11205	7464	323.30	27	68.57	CHANGED	tpascG+hssc-Rl-lll-sGS.Fsph-shhtpcssphuh...c..hPssullTGhGsltGptshlhupDhsshGGshushputK...lsch.chAlps...............GtPhlslsDuuGA....c.t-GVpsLpGhGpIFtpsspASu.sIPpIollhGsssGGuuY.PuLsDhslhVcs.tuhhalTGPsllc..............pVhG..EphospphGGuptHhtpoGluHhsupsD.-ulphl+chlSalP...sst.......ssPlhtshDssc+..............shlPss.ppsYDsRplIptlsD.............pupFhEhpssaApslVsGhARlsGhsVGllANpsp......................AG.sL..cSu.KsAcFlchCss.hslPllhLsshsGFhsGpcpEasGIl+aGAKllhAhucusVPtlolIst..cuaGGualVMsupthsschh...huassAcluVMGscGAssIlaRcchttts.........p.pth....................hppphtchccphsssYhssuptasDsllcPschRs+lshshphhhpcpt.hh.h+p+tpl	.......................................................................................................................................................c..................p....h...................h...............t.....................................h...........t............................t.............................t......t....................................ssul....l.sG....h...G....p....l......p.............G.......h...................s.......h.l.hs.....D..hs.............hh.uGo.hush.sucK..........ls+hh-hAhpp...................................p.h.P.l..l.hl..s.s..S.GG.........A.......R...........h.....Q.......E............u......hh..............u......L.......h..............t...h..u..+...l..............t......s.........t..p.....h..p...........t..t...........ls.I.o.l....l.h.sP..s..sG..G..s.A...h.s..h......h.s..D.......h.......h.......lh..p.....uhl.hhsGPcVl.c...............................p.s..h....s......E......h........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	955	1849	2497
+115	PF00755	Carn_acyltransf		Choline/Carnitine o-acyltransferase	Bateman A	anon	Pfam-B_438 (release 2.1)	Family	\N	19.40	19.40	20.50	19.40	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	591	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.77	0.70	-6.43	17	1813	2012-10-02 12:01:53	2003-04-07 12:59:11	15	34	362	41	1101	1697	26	442.50	26	79.93	CHANGED	sLP+LPVPsLpcTls+YLc.ulcPlhs-.-paccopplspcFss...shGppLQchLhphuttp......sNWlscaWhphhYLphR.hPlslNSs.h..sshsph.hpsp.........psQhtpAuplhpshlpahptlcpcpl...........sphhtG....................ttPlsMsQapplFsosRl...PGhp...pDslhphtcsc.......HllVlp+spaaplclhcs..suphlo.s-ltpQLppIhppupp.psh.tsluhLTopsRspWApsRptLhpsss..NpcsLctI-pulFslsLDcs..................pss.cs....t..hphh.........htss.p...ssutNRWaDKohphllspsGpsGhshEHossDGhsllplh-h.h.hspphhc......................phhts.s......lshPp+Lpaplssp.hpspIpputpphpthhs-L-lhshpFpsaGKshlKp.pplSPDuFIQlAlQLAaY+.haG+hssTYEoAosRhFtcGRTETlRosos-uhcFVpuM...........s..sstott-.............+hpLhpcAsppHsphhcpshpGpGlDRHLhuLphlupt.....pslphP..c...hahcpsathu...sshhlS.....os..plssphhhhhs...aGPVssDGYGlsYphp.ppplhhslSuapSsspTsup+asphLpcAhp-hts	..........................................................................................................................................................LP.p.lPlP.lppThp...pa.lt..shps..l..........h........s...................p..............p..............h..............t......p..........h..........pt...h....sppF.t.......................t.u.........LpthL....ht....t.........................psa.........l..............t....p....hW.p.......h.h....ht....c.........sl.hss..............h.........................................................t...t....h..h.uuth.h..s.h...h..ah..t..lcpttl..........................s.h.hht...............................................Phs.tpa.h...hFsssRl...P...t.t........tD.h..t.......tsp......................HlhVhpps.pha..hh...h..ht.................s...p........h..p.......tpl.....p....hp........l...h...........p....t..s.t.....................................................t..........................lu.hLTst....tRs....Wu.ph+p....hh.t...tt.......NtpsL.p.h.lcp.uhhhlsLDp.............................t.t...............................................tt.h.h......tp.s...hsRWaDK....s.hp...h.ll...tsG...............p.h.uh..hEH.s.....h.Du..hhphh...p.hh..........t...........................................t.t................s.s..ptl.pa..p.....hs..t........h..t........lt.......u.....t.th.t..t.hhpphp.h.h..h...a.t.t.......a.G..+.t..h..hKp...th..S.PDuhlQhs..hQ.hAa.a.p........h.s........p......................sY..Ess.h+hFhpGR.T-.....sh..R.sso.pshta...sps..h..................................................p.......t...s...tp.............................................................................hhthhptAhptH..th.h..t......s.....GtGhDRHLhsLh.h.t...............................................t....P.....t................h......s.......ath.......tp..h.p...................hs...........ph.s.s...h.......h...h...s....a.us.................s...................pG..aG..hsY......p...h...hthssh........................h..pst......th...l.t.h.ph.........................................................................................................................	1	386	559	894
+116	PF03378	CAS_CSE1		CAS/CSE protein, C-terminus	Mifsud W	anon	Pfam-B_3786 (release 6.6)	Family	Mammalian cellular apoptosis susceptibility (CAS) proteins are homologous to the yeast chromosome-segregation protein, CSE1 [1]. This family aligns the C-terminal halves (approximately). CAS is involved in both cellular apoptosis and proliferation [2,3]. Apoptosis is inhibited in CAS-depleted cells, while the expression of CAS correlates to the degree of cellular proliferation.  Like CSE1, it is essential for the mitotic checkpoint in the cell cycle (CAS depletion blocks the cell in the G2 phase), and has been shown to be associated with the microtubule network and the mitotic spindle [3], as is the protein MEK, which is thought to regulate the intracellular localisation (predominantly nuclear vs. predominantly cytosolic) of CAS. In the nucleus, CAS acts as a nuclear transport factor in the importin pathway [4]. The importin pathway mediates the nuclear transport of several proteins that are necessary for mitosis and further progression. CAS is therefore thought to affect the cell cycle through its effect on the nuclear transport of these proteins [4]. Since apoptosis also requires the nuclear import of several proteins (such as P53 and transcription factors), it has been suggested that CAS also enables apoptosis by facilitating the nuclear import of at least a subset of these essential proteins [5].	19.60	19.60	19.60	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.31	0.70	-6.18	16	387	2012-10-11 20:00:58	2003-04-07 12:59:11	10	14	287	3	271	370	12	387.00	29	44.71	CHANGED	ERlLhlpcsssp.slhsss-lsPhsppLLspLFphlphssS....pENEalMKClMRVLhllp-ullPh.ssslLs+LssIhphluKNPSNP+FtaYhFEulushlRhsspusss...sFEpuLaPsFssILppDVp.....................EFhPYV.........FQlhu......tLLEhss.ssslPs.sYhsLhsslL..................sPshWEppGNlPuLlRLLpAhIt+uuppI..sssspLpslLGIFQKLluSKs.sDppGF.LLpullpphPssslp.YhtpIhpllFpRLQsSKTs+FhpphlhFhphhss+p.....GushhIphh-slQsslFs.lh.plllP-hpKlutsl-RKlssluhTKhL.sEo.Ahhsp.YtKhWuhhhpuLlpLhchPspsss....c--hls.tDss.hGassuFopLssstpptcDPhP-..lsDsKhalup.LpchsptpsG+lsshlsppLss-uppsLtpY	...............................................................................E+lhhh...p...t..s....t..tt...l....h.stscl.tPhs.p.LLppLFphl.ph.sso...............tENEalM+..slMRs.h.hhp........-sh.h..sh.hs.sllsp.Lhp.......hl.thls+N....PS.pPcFsHYhFEuluhh.....l+..h.ssp...s...ss.s..h.....phEps..LassFp.tILppDVp.....................EFhPYl..............FQ...lhu......hLLEh...p..................s......sl........P.p.sYhsLhs.LL..........................p.P.slW..-.pp.G....Nl.PuLlRLLpuhlp+ss..ptl..............ht..t..s.pltslLGlF.Q.+LluoKs...s-....pt...GF........LLpslltph...s...p...lp...a...h.tp.IhhllhpR.L.Q.s....u....+T...s.......c..ahpphl.hF..hs..hhshph.....................usshllphh.-.pl...Q....s..t............hFs.lhp...pl...h...lP....ph..p.p..l....................s.t...h...-.+Klssluho+hL..s.p.s.....h.hs....p.....h.tphWs...hhpuLlt...lhp...........s............t.s.sh...................pcc...h.........h..s....t.............-.s.....................u.......a.ts.u.......aspLshst.t.t..h..Dshsp....l...t...s...sp..alsp...Ltphs.tt.p.s.sth.thht..h...................................................................................	0	103	159	224
+117	PF00690	Cation_ATPase_N	Na_K_ATPase_N; 	Cation transporter/ATPase, N-terminus	Bateman A, Griffiths-Jones SR	anon	Pfam-B_138 (release 2.1)	Domain	Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.10	0.72	-4.51	168	9625	2009-01-15 18:05:59	2003-04-07 12:59:11	21	104	3314	73	3641	8446	271	66.10	25	7.18	CHANGED	hpphsscplhppL.......p.ss.......ppGL.op....ppsppRh....ppaG.Nplt.ptctpshhthhlppa.psshlllLlhuullS	...............................................s.pplhpph.................p...s......................ppG....L...os...............p-s......p....c..Rh.................ppa.G.....N.........p..l......s...tpc.....tpsh.......hh..hhhpp.a.ps..shh.h...lLhhuAllS...................................	0	1148	2096	2947
+118	PF01545	Cation_efflux		Cation efflux family	Bateman A	anon	Pfam-B_232 (release 4.0)	Family	Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.	22.80	22.80	22.80	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.80	0.70	-5.34	89	12806	2012-10-02 19:55:49	2003-04-07 12:59:11	16	54	4824	10	4122	10055	1117	268.50	19	81.33	CHANGED	lhlulhhshh.hslhclhsuhhs.sShulluDuhashhDhhuthlslhuhphu...................p+.sssppa.......sa..Gat+hEslsulhsulhllhh.uhhhhhp....ulpphlps....................tphphshh.hhh...................h.sllu.....lslshhhhhhhpp.......................................................................................................................................hp..ots....l.pusthchhs...Dshso....luslluhllhhhh.......................hhh..................hDslsulllulhllhsuhplh+puht.Llsts.sssthh...pplpphl...........hsslh.slpcl+hhphGs...phhlslplp.hsssh...shpphcp..........ltpplcptlppphstltp...h..lp.hpsttptp	....................................................................................................h.hhuhhhshh.hh.lhch...h...s...u...h...hs...s.......ShulluDuhc.lsDh............hu.hl.............s..lh..u..h......phu...............................................................p+...s.s....s.tpa.......................sa...........Ga......t.+......hEh.l.uuhhs.u.l.........h..lh..hh..u...h.h.l.lh.c.......ulp+.l...hps.................................................................ptlp.ss...hh...hhh............................................................................uhlu........ll.s...s..h.h..hhhhhtc.......................................................................................................................................................................................................................................................................................t......................................................................................................................................hp...s.s.......l...p...ush..h..c..hhs....Ds.lso....................luslluhllhhhs.........................................................shhh..........................................hDslhulllul.hllh.s..uhplh..pc...uhphLhpt...s....st....ph..........................ppl.p.phl.p.........................hstlh...s.l...c..c..l..+..s.h.......p..hus...........phhhsh+l....h.s..sph...............h..ph.pt.........................................lhpplpp.hl.....tp.p.h......t.lt.t....hh.lp..h-.....t..........................................................................................................................................	1	1327	2487	3430
+119	PF04586	Peptidase_U35	Caudo_protease; 	Caudovirus prohead protease	Waterfield DI, Finn RD	anon	Pfam-B_4836 (release 7.5)	Family	Family of Caudovirus prohead proteases also found in a number of bacteria possibly as the result of horizontal transfer. 	20.70	20.70	20.80	20.90	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.00	0.71	-4.22	36	1699	2012-10-01 19:43:34	2003-04-07 12:59:11	12	10	1302	0	286	1376	536	154.10	23	52.03	CHANGED	psh-l+stp...pst.....lpGYAshFsp.sp.........htEhltsGAFspsLtp.ts....lhhLasHDt.sp.slGpsps.........cLppDspGLchchcl..sssstuc-l.hphl+pGslsuhShGFpsh.....ppphptps.........hRplpcl-.Lh..ElSlVoh.PAhscuplp......tpshpphtph	............................................................................t.....p..t........tt...hhhpGaushas....s.................ht-hlt.s.sA.h.p..tsh.tp...s..........lhhLa.......pH........c..........s.........p.........s...l...Gpsp...........pl.p.......D.......spG.L.hhcsch.......ss.......s.....s.......tuc-h...h...t...t...l..+....s..G...s.l.suh..S..hGFpst...............p.phppss.......................t........hpplpchc.Lh..ElSl...V..o...h...PA..spsplp......hpt......t..........................................	0	81	174	230
+120	PF01607	CBM_14	Chitin_bind_2; 	Chitin binding Peritrophin-A domain	Tellam RL, Hutter H, Bateman A	anon	[1]	Domain	This domain is called the Peritrophin-A domain and is found in chitin binding proteins particularly peritrophic matrix proteins of insects and animal chitinases. Copies of the domain are also found in some baculoviruses. Relevant references that describe proteins with this domain include [1-3]. It is an extracellular domain that contains six conserved cysteines that probably form three disulphide bridges. Chitin binding has been demonstrated for a protein containing only two of these domains [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.46	0.72	-4.04	209	6920	2012-10-01 20:20:38	2003-04-07 12:59:11	19	153	308	1	4290	7189	6	53.80	23	23.27	CHANGED	Cst..........tsGhhss......ssC.spa.hhCt......supsh.......hhpCssG.hhFst.....ptptCshspp.........spC	.............................C..........tu.h.hsp......spsC...spa.ahCh.........s.G.p.sh................hhpC.s........s........G........h......hF...st...................ptp...t....Cshspp..........tC.......................	0	1391	1754	3585
+121	PF00942	CBM_3	Cellulose_bind; CBD_3; 	Cellulose binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1126 (release 3.0)	Domain	\N	20.60	20.60	20.70	20.80	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-9.79	0.72	-3.96	29	651	2012-10-01 21:34:18	2003-04-07 12:59:11	13	120	165	35	192	639	2	83.10	27	12.10	CHANGED	l.hcsusss.ussNtlcs+hplpN.oGssuhsLsclplRYaash-t.thstsahsc.sslu.........susl.hshsphss.ssu.ssaYlEls	................h.hpsssss..sssspIpsphplhN.oGssslsLsclplRYaash-.t..st...s.tshs..sDauplu..............su..sl.p.....tp.hsp.lpsstss..AshYlElu............................	0	101	152	164
+122	PF02018	CBM_4_9	CBD_6; CBM_4; 	Carbohydrate binding domain	Bateman A	anon	Chris Ponting	Domain	This family includes diverse carbohydrate binding domains.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.94	0.71	-4.14	47	1727	2012-10-03 19:46:52	2003-04-07 12:59:11	12	250	613	41	590	1782	213	134.50	15	21.89	CHANGED	sshlhsssFEs...................shssWtspsss.............ssssss.....sGphslplsspss.....sasuhhhphs..stlppGpsYplShhsptsss........pplplplphpss.........shpthts......thshs.spWpplpss.aThs...sssssshlhlps..........ssss	...........................................................................thl.NssF-p..............................sh.ss...Wp..s....hs.ss...........................sshsss..................sGs..h.s..l..t....l......s...s...tss..........shss...h..h.h.p..hs....hslp..t....Gp.s.YplShhs+ssss.................tplplplptsss...................htth.ts...............tsshs..spWpp.h..p.hs.ashs.....ssssps.lhht.......sts..............................................................	0	271	468	540
+123	PF03422	CBM_6		Carbohydrate binding module (family 6)	Bateman A	anon	Pfam-B_1231 (release 6.6)	Family	\N	21.00	21.00	21.20	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.65	0.71	-3.97	41	1755	2012-10-03 19:46:52	2003-04-07 12:59:11	10	402	465	60	713	1810	331	121.80	21	17.74	CHANGED	cAEsastt..uGlshpppss..t.....sGhslshhssG-Wlsast..lchssuushphp.spVAsssus...usl-lclsu.....suslluolsl.ss.TGuWpsa.......tsspsslshss.Gs+slhLshsust......hhNlDahpFsp	...........................................................ht.......t.u.hphtspst....t...........sGhsl...u..h...h.p.s...G....-..a..l..pas....Vs.hs...s..u...u..s......h.....s.hp..h.+s..A.ss.sss...........uslpl.p.lsu...............ss.h.l...u..s.hs.l...s......s.....TGu.......W.p....s..a......................ps.h..s..s.s..l..s..hss...G.s.p.s..lhlhhsuss............hNlDhhph...........................................	0	338	629	686
+124	PF00571	CBS		CBS domain	Bateman A	anon	[1]	Domain	CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5].  CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5].	24.00	16.50	24.00	16.50	23.90	16.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.50	0.72	-4.16	850	77225	2010-01-08 14:28:41	2003-04-07 12:59:11	23	464	5124	378	23594	56987	15502	57.10	19	26.04	CHANGED	lpcl..hsp..............sshs..ls.s....sslp.cshp..hht.....cpp......hp.tls.V.....ls......cp...........scll..Gl.lohpDllpthht	............................................................................th.hp.................phhs....ls.s..........tslp..cshp.....hhp...........................cpp............................hptlsV.......................ls.......................................-p.............................spll.....GllohcDlhp....t........................................	0	7547	14981	19849
+125	PF02754	CCG	DUF224; 	Cysteine-rich domain	Bateman A	anon	Bateman A	Family	The key element of this family is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins [2]. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster [2]. The family includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase [1] Swiss:P52074 and glycerol-3-phosphate dehydrogenase.	20.60	11.80	20.60	11.80	20.50	11.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.31	0.72	-3.98	61	13777	2009-01-15 18:05:59	2003-04-07 12:59:11	11	93	2942	0	4139	10623	3794	86.00	20	33.05	CHANGED	lsaasuC..hhcst........h.pstphhtplhshhshch.h..ptptCCGusuhhsst...pt......huh....plsppplpphpc...h.s.....s-hllssCssChhplc	...........................................lsaassC...hhchh...........................ttps.t.p.s.h..t...p.l.h...t..t...t........s..h.....c.....l...h.....h............t.....t....p...t....C...C.Gt.su.t.h..s.sp..............pt.........hup..............ph..s.pp....p.l....c....t.h.pp...............t...t...........................sc..h..l..lsss..s.s.Chhtl.t.......................................................	1	1454	2943	3646
+126	PF03379	CcmB		CcmB protein	Mifsud W	anon	Pfam-B_3059 (release 6.6)	Family	CcmB is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor. CcmB is required for the export of haem to the periplasm.	23.10	23.10	23.10	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.43	0.70	-5.13	13	1869	2012-10-03 10:13:34	2003-04-07 12:59:11	8	2	1817	0	379	1383	1059	208.50	38	96.40	CHANGED	hhsllpR-L+lAhRssushhssLhFFLlVlsLhPlulGP-splLuRIAPGIlWluALLusLLuL-RlFtsDaEDGSL-...lhhsshPLthllluKshAHWllTGLPLllsuPLhuLLLsLshsuassLhhTLLLGTPsLShlGulGuALTVGL+RGG..lLLuLLlLPLhIPlLIFusuAlpsuuhs...hshss.hhlLuuhhlsslsLuPFAsAAALRl	..................................................................htlhth-Lpluh..R...p...tuplh....ssLhFF.Ll.V....Is..L.F.PL...u..l....G....P......-.......s..p.....L.......L........s..+...lu.PGll.......W.luALL.uuL.L...u.L..-RL.FR.....sDhpDG..oLEp..lhL...t..s..hP..........L..s.hllLuKlhA...H...W....l.lo.G.L..P.L.ll.lu.P.l..l..u.l.h.L...s.....h.....s...s..t....u....h....t....h....h....h.L....o..L.L..L...G.T..P.s.L.u.h..lG.AlGsA.LTlGL++G.G....lL...Lul..LlLP.L.hlPlLIFu.su...Ahsuushs......hshs...u.......L....t.l....LuAhhhh....s....h.s.L.s.PhAhuuuL+........................................................	0	109	232	305
+127	PF04103	CD20		CD20-like family	Bateman A, Moxon SJ, Pollington J, Finn RD	anon	Pfam-B_1979 (rel 7.3), Pfam-B_10092 (rel 9.0)	Family	This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm [1]. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts [2]. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton [3].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.79	0.71	-4.28	80	1022	2012-10-02 01:14:40	2003-04-07 12:59:11	10	9	113	4	533	1008	0	133.70	19	47.50	CHANGED	sLGsl...QIhlGlhplslG..hlhhhhh.s.........hhhhsGhPaWuulhalluGsLu.lsuppcss....phllpsslshNllSslsAhsulllhshslthtp.hhth.........................................tshhhstph.......htulhsslLlhslLphhlulshshhss	........................................LGhh...QlhlGlhhh.sh.G...hh.h.hh.h.hs..................hhht.uh.sh.W.u..uh..h..hll.uG.lu.lhs.....tppsp...........phh.hp..s.phshs.l.lus.hh..u.h.......s........uhhlh..shsh......th.t.h.............................................................................................................................h..............hhsl.hhhh.hhshlphhlsh..shh....................................................................................	0	125	173	258
+128	PF05179	CDC73	Cdc73; 	RNA pol II accessory factor, Cdc73 family	Wood V, Bateman A	anon	Pfam-B_6394 (release 7.7)	Family	\N	25.00	25.00	25.70	27.20	22.40	24.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.79	0.70	-5.04	6	336	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	288	1	245	334	3	259.70	26	58.02	CHANGED	Tcsplhlpstchh.thslhshhpuspspp-.s+sp.ssss.sostscc.plctpptp..upaspaspcphss..p.scthcIsshGSh+GssLsulcpG...........................h.....ssupu+tstss.suK+ssRsPIIllPSAsoSLIThhNlK-hLp-hpaVP..sst++tpGsp+ssplslQ++psp.p........ThsacVlDsspKLp.P--WDRVVAVFVhG.sWQFKsW.W...s.sPs-IFs+IpuFal+aspD..cssssVppWNVchlplSpsKRHhDRsVhpphWEoLE+altp+	........................................................................................................................................................................................................................................................................................t........................................h.st.hh..t.........t...htthp..s.shup....h...t.t....s....h........hppt..........................................................................h.....s.s.t..s..t.....sp...p.........t.......p.....p.t.p....p..s..PI...I...lls.s..u..s........o..S..LlshhNsKp..hL.p-..tp..a.ls........spp..t...p...t....p.........s....s...t...p.p..s.l.h........lp..+......p.h.p.ph..............................shp...ah...lV..Ds..s...t.ph..........p.....s...........c.WsRVVAVF..sp.....Gts...W...QFKsa....W.........s.s.P.....s.....-lFp+...........lpGaalpacsp.......phstp.V..ppW.................s..Vphl..p..l.......sc................p..K...............RahD+tsh.pFWcpl-.chhh.............................	0	84	131	200
+129	PF01066	CDP-OH_P_transf		CDP-alcohol phosphatidyltransferase	Finn RD, Bateman A	anon	Pfam-B_651 (release 3.0)	Family	All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.44	0.72	-3.71	124	11822	2009-01-15 18:05:59	2003-04-07 12:59:11	16	43	4879	0	3729	8699	4901	147.30	20	63.29	CHANGED	hhhhPNh..lT...h....hslhh.uhhsshhhhhs.....ph..........................................hhushhhhlshlhDslDGtlARthspsSt....hGthlDshsD........thshshhh....................................................................hslhhhhshhhsshhhhhhht	.............................................................h...hPNhlT.l....hp.lhh.....s...h.h..h.hh.hh.hs.....th..................................................................................................hhusllhhlusl...hDhl.....DGhlAR....p.h..s.t.s..op............hGthLDs..luD.....plh.hs..sshhhhh.........................................................................................................h.h...............................hhhhhhhhhhhhh..........................................................................................................................................................................................................................................................	0	1273	2397	3165
+130	PF00150	Cellulase	cellulase; 	Cellulase (glycosyl hydrolase family 5)	Sonnhammer ELL	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.05	0.70	-5.20	65	5309	2012-10-03 05:44:19	2003-04-07 12:59:11	13	205	1466	165	2106	7158	527	265.90	14	56.85	CHANGED	lstsGpsh.....phhGhsst.........W..tsth.....stpshhphhpshGhNslRlshs......h.........ssah.....s.s.sh........s.......thhsclcpllshu.hspGhYl.IlDhHp........................................ts.tsshss............spsh................Fpp..........h..lAs+a...ssss.pllaE..lhNEPps.st..........stW...............stlpshsppslssIRss.uss...phIllsssp..............................Wus..........ssst.shs.......P..................ts..........tsplhaohHhYs.ssphs.t....................................................spthpsthphh.hspGh.slhluEaGss.....ssss.................tspsstW......lshh......ppp.slshsh.Wshssps	...........................................................................................................................................h.............................................................pp.h.p...h.h....p..s....hG.h.shl.R.l..s.ht.........................................h.................tth.........................t..sh.....................................hst........................................s.h.h.p..t...l..c..p........h...l.p.h......s...pp..t...G..l..h....l.....l...l.....-....h....Hs.................................................h.......................................................t..t.............t.....p.......tt...............................st.ph.............................................................................ht.p.............................h.h....p....t....l....u....p........p........a................s.....p.....s...s....hl.......h........a.-...l.hN....E...Pts........................................................................t..h...t....t.h..h....p...phh...p..t..l+..........t...h....s.sp.........thl....hl..s...s....t..............................................................................ast.................................t.t......hhp................P.....................................t.p..h.h.....h......s.h.H.....Y....s.................................................................................................................t.t.......h.p..t..h...h....t.......h.......h..p..t...s......h....s...h...hls..E......aGh......................t.......................................h....................ht.h...................t.......................h......t...................................................................................................................................................................................................................................	0	829	1465	1881
+131	PF04218	CENP-B_N		CENP-B N-terminal DNA-binding domain	Bateman A	anon	Bateman A	Domain	Centromere Protein B (CENP-B) is a DNA-binding protein localised to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.33	0.72	-4.54	6	534	2012-10-04 14:01:11	2003-04-07 12:59:11	8	19	145	3	370	898	32	51.80	26	11.42	CHANGED	++pRssLThcEKlclIpphE-sp..S+sslA+caslstoTlpsIlcpKcplLpth	..........................p.+ps..Lolc-Klcll.pp.l..-p.Gp......s.pspluccaGl.scoTlps.lhK.s.+cclh...h..............	1	79	158	248
+132	PF04734	Ceramidase_alk		Neutral/alkaline non-lysosomal ceramidase	Mifsud W	anon	Pfam-B_3385 (release 7.5)	Family	This family represents a group of neutral/alkaline ceramidases found in both bacteria and eukaryotes [1,2,3].	19.40	19.40	19.40	19.50	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	674	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.05	0.70	-6.65	42	810	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	474	3	419	771	118	444.80	26	82.17	CHANGED	sYllGsGpADITGPssElshhGYAshpQhusGl+pRlauRAFIlu..ppss.........pRhValshDsshhspuV+hsVLctLps..phs.shYscpNVslouTHoHuGPGGahpYhLhpl.....oohGFscpsapAlV-GIlhSIp+AHpsLp....PGplhhups-ltsAslNRSshAY.sNPpcERupY......stsVDKphTlL+hsc.ssspslGslsWFuVHsTSMsssNpLlSGDNKGhAAalaEcphp.....................................................................sp.ss.tssFVAuFuQoNsGDsSPNlhGshC.p.oG..Cph.pSoCs.utsthChupGP..tt..sthcSsplIGc+QaptAppLas.....susp.lsGs..VcshHtalDhsshshs..........sthssss..h+TCsAAhGaSFAAG.ToDGP........G................h....FsFsQuss....pssP.............hWphlpshl..t.PotcpppCQtPKPI..LLssGphs.PYsWsPsIlslQllRlGpLhllusPuEhTTMuGRRhRcsltsshtssh................p.pVVluGhuNsYupYlsT.EEYslQRYEGASTLaGPaTLsAYhp.htphhsuLssu......tss....ssGP......pPPs.p.scplohhsuV.laDstPhspsFGDVhsp..ssss.YphG.-s.VsssFhuuNPRN..sL+p-sTahtVE+hp...................tsssWpsVtsDsDWshhacWc.......Rsssh.s..tScsTlpWpI.........PpsstsGsYRl+aaG.shKshhsu....lpsapGsopsFpVt	..................................................................................................hGhshhDhT...s.........h..thshhG.Y..up......p.ph..s..tGlcp+lhuRualht........tt.....................tp+hlh.ls.hDhhhh......p.....t.....lp.....tlhp.p.ltt.......tht.s..a..p..pp...sl...hlsuTHoHu.u......P......u....u..h....h....t.....h.h..h.th.........s.t.....u...a...p.t..........h..p.h.l.V.s.u.....lh...pul.pApps..lt..........s.upl.h.sp.s..............pl....s...ss..h.N.R.......s.........................s....a...........t....NP........t...pt.tth.......................ttssDtphshlph.p.......ss....p.....h.Ghl..sa.ass.Hs....s.s..h.t......s.s......s...p.....hlouD...hG.h.sshhhEp.ht.......................................................................................................................................................................h.......up.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s................................................................................................................................	1	157	259	363
+133	PF03859	CG-1		CG-1 domain	Bouche N, Bateman A	anon	Pfam-B_18451 (Release 7.1)	Domain	CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein [1]. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs [2].	23.10	23.10	23.80	30.40	22.80	22.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.57	0.71	-4.56	15	270	2009-09-10 19:07:15	2003-04-07 12:59:11	11	34	93	0	157	282	2	111.00	51	10.85	CHANGED	lhpEs+pRWL+sp............ElhtILt..sac+athh...pssp+PtSGSlhLasRKVlRhFRKDGHsW+KKKDGKTl+EAHE+LKVGs...................l-sLpCYYAHu..-psssFpRRsYWLLppshpcIVLVHYhcVp	........................................h...p.phRW.psp............EIsthLh....saccap...h.....pP.sRPt............sGSlhLasRKhl+..aRK.DGasW+K+KDGKT...s+EsH.KLKVtu...................h-s..LashYsHu......p.sPsFpRRsYWLLp.ps..cIVLVHYhpV..............................	0	32	82	120
+134	PF00307	CH	actinin-binding; 	Calponin homology (CH) domain	Finn RD	anon	Prosite	Domain	The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1].  The CH domain is involved in actin binding in some members of the family.  However in calponins there is evidence that the CH domain is not involved in its actin binding activity [4].  Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin and Swiss:P15498 have only a single copy.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.54	0.72	-4.01	194	10780	2012-10-03 10:10:54	2003-04-07 12:59:11	26	564	496	152	5898	10465	47	104.80	20	12.85	CHANGED	ccshlpWls.ptht..t....................................................................th.tlp.......sh.tpslpDGhhLspLlctl.pP...ph.........h.shppl..........p...........pphcNhphslp...hspc.hGhshhh........sspDlh.....pss.p........llshlhplhphht	................................................................................................................................................................................................pthhpWhp.ptht....t..................................................................................................th.plp.................sh..tpsh.p......D.G.hsL..s..tL....l....c.t..l...p.P.....sh........................................l..s.h.ppl..................................................p..................p...thc.Nl..p.h.slp...............hsc......p..........h.Gl.phhh...............sscDls............css.p.............llshlhplhth..t..............................................................................................	0	1688	2487	4051
+135	PF04420	CHD5		CHD5-like protein	Bateman A, Wood V, Mistry J	anon	Wood V	Family	Members of this family are probably coiled-coil proteins that are similar to the CHD5 (Congenital heart disease 5) protein. In Saccharomyces cerevisiae this protein localises to the ER and is thought to play a homeostatic role [2].	29.30	29.30	30.00	29.50	28.70	29.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.77	0.71	-4.57	27	271	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	233	14	174	269	0	152.20	27	75.98	CHANGED	lhslFhl.lhphLlsshtsutlspllhhhh.t.......spphpptpphpcElhpl+pEhsshSuQDcaAKWsKLpRch-Klpp-lcphspplsuppsphcthlphhhhlhssshhhhLphaatKsPlahLP...pshhPhhlchllu.....hPpushG..........................uVSlshWhhssss	.................................lhhh.lhh.llssh.ss...hlsphl..h..........ppssppppph+tEltph+cEhssl...Ss...tD...EFA+aA...K...L...cR+hsKhpccLcs...........hspphsuppsphchhlshshhlhpsshhhhLhhhat.psPlhhlP...psah..h.lphllu........FPpsshG........................uVulssWhhsCt........................................	1	44	83	135
+136	PF03067	Chitin_bind_3		Chitin binding domain	Bateman A	anon	Pfam-B_2364 (release 6.4)	Domain	This domain is found associated with a wide variety of cellulose binding domain. This domain however is a chitin binding domain. This domain is found in isolation in baculoviral spheroidins and spindolins, protein of unknown function.	21.20	21.20	21.40	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.76	0.71	-4.02	128	1556	2010-01-08 15:51:16	2003-04-07 12:59:11	10	34	838	15	481	1278	28	176.70	28	53.03	CHANGED	HGalpp.....PsuRshhCth.ss....................t....t...............................tsu.sspap.psh.Eusts..............h.pts.s..........DGplCuA.Gs.........s...phss....lD.ts...ss.pWtps...sl..........pssts..hshpaphT.AsH..tsshacaalT...Kssasssps..LshssL-hh.sh.........tt.t...........ts...ssstpa....ssslPp.......RsGppVlhshWphu...Dsss...................uFYsCsDVs	...............................................................................HGalpp.....P.s.SRshhCt.sss.......................................................s.....psG...ssta.ps..pul.Eusts...........................h.tts..s.......DGplsuu.Gs................t........thss.L.D.tps....us...cW.h+s..sl......................psG.s......hshpWphT...As..H....ts........upacaY.l..T........Kssa....s...s...sps....Lsh..ssh-hh...sh.t..h.....st.t...............................................................s.....sssssa......psslPss........RsG.hpV......l.hshWphu...D..oss..............................................................uFYsshDVs...........................................................................	0	173	287	412
+137	PF00379	Chitin_bind_4	insect_cuticle; 	Insect cuticle protein	Finn RD	anon	Prosite	Family	Many insect cuticular proteins include a 35-36 amino acid motif known as the R&R consensus. The extensive conservation of this region led to the suggestion that it functions to bind chitin. Provocatively, it has no sequence similarity to the well-known cysteine-containing chitin-binding domain found in chitinases and some peritrophic membrane proteins. Chitin binding has been shown experimentally for this region [1]. Thus arthropods have two distinct classes of chitin binding proteins, those with the chitin-binding domain found in lectins, chitinases and peritrophic membranes (cysCBD) and those with the cuticular protein chitin-binding domain (non-cysCBD) [1].	21.50	21.50	21.50	21.50	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.69	0.72	-3.70	157	3539	2009-01-15 18:05:59	2003-04-07 12:59:11	18	25	87	0	2490	3895	1	53.00	32	25.39	CHANGED	YpasYpsssu.tt.....pppup...............tsstslp.GsYoahssD.Gp.hhsVp.Y.sA.Dcs.G.F	..........................................YpasY..ps...pD..s...ps..............pppsp............................sussVp.GsYo..h..hssD.Gp..hpsVp.Y.sA.Dc.s.GF..........	0	942	1256	2169
+138	PF04968	CHORD		CHORD 	Finn RD	anon	Pfam-B_1217 (release 7.0)	Family	CHORD represents a Zn binding domain. Silencing of the  C. elegans CHORD-containing gene results in semisterility and embryo lethality, suggesting an essential function of  the wild-type gene in nematode development [1]. 	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.57	0.72	-3.73	47	678	2009-09-11 00:43:51	2003-04-07 12:59:11	7	14	243	3	422	649	3	62.90	45	38.49	CHANGED	hstpCpNtGCsppap.ssc....s.scssChaHPGsPlFH-uhKtWoCCpp+...shDFs-FhpI.GCsp.GpHs	.................h.htCpppGCu..p....pas....s..s..p...............s...pc-sCtYHPG..sP..lFH.........-uh...K..............uWSCCcc+...shDFspFLsI.GCsp.GpH..................	0	135	212	319
+139	PF02017	CIDE-N		CIDE-N domain	Bateman A	anon	[3]	Domain	This domain is found in CAD nuclease Swiss:O76075 , ICAD Swiss:O00273 the inhibitor of CAD nuclease. The two proteins interact through this domain.	21.80	21.80	21.90	22.20	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.51	0.72	-4.21	7	382	2012-10-03 10:59:06	2003-04-07 12:59:11	10	9	81	7	199	371	0	76.00	38	26.28	CHANGED	p.+Ph+lpshcpsh++GVsApSLpELlsKst-hhtlsp..tssoLsLtEDGT.V-sE-aF.sLscsTchhlLttGppWps	....................+Ph+lpstpRsh++GlsA.soLpELhp..K..........sp..........c..t..L.tls................tsssL.VL..-.EDGTtV-sE-YFpsLssNTphhlLppGppWp...................	1	36	51	107
+140	PF02487	CLN3		CLN3 protein	Mian N, Bateman A	anon	Pfam-B_1060 (release 5.4)	Family	This is a family of proteins from the CLN3 gene. A missense mutation of glutamic acid (E) to lysine (K) at position 295 in the human protein (Swiss:Q13286) has been implicated in Juvenile neuronal ceroid  lipofuscinosis (Batten disease) [1].	24.50	24.50	25.00	25.10	23.60	24.40	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.29	0.70	-5.69	2	477	2012-10-03 03:33:39	2003-04-07 12:59:11	12	13	234	0	293	463	9	272.00	30	81.25	CHANGED	.hhhFWLhGLhNNh.YVVhLSAAhDIlu...............P..shs.......pSl....VLLADIhPoLhIKLhuPhhlchl.YS.Rlhs.hhhushuhhLVuF.+slhssLhGlshASISSGhGEVTFLpLTtaY.phslshWSSGTGGAGlhGuhSYhhLTp.htlssphTLLsh.hlP..hhh.aaFhLpSs-sp.shtp.pt.spAcps.lss..ss.o+ss......Sop.pl.pphphh+tLla.YhVPLshVYhhEYhINQulh.hLhF..s............hpatp.YhhYthLYQhGVFlSRS.hHhhRhR.halLAhLQslNLshhllpsWF.hh.S.ahVhllIhYEGhLGGAuYVNTFhNIh.ppsspcpEFAMuAssIuDohGl.LuuLLuLsLcshLC+hp	.....................................................s.......................................................................................................................lllsslhPshhh+h..h..P.h.hh...hl.a.......Rhhh.hh.hthh.uhh.......hl....uh..........s..............t.......s......h................h..t......l..hGlhhsShuuuhGEhshLt.h.st.ha.........................s...l.shauuGTGhuGlhGuh.a.h.hhpt...hths.t...shh......h.s....h.a......hh.....h.....l..............................................................................................................................................................................................................................................h.......t.....p.h......h....h..........h....hh..hh.hPLh.hVYh...hE...Yhlspul..h..lha................p.h..t.t...Y.hh.thhY....Q.......h.....G....VFhSRS....o.........h...............h.........h..........p........h...........p......hhh....shhQh...h.hhh...h.h..........hts...........h...h..................h.......h.........p....................h.......hlh.hl....hhh.GhhGGhsYVNs.a.............h............h........p.........................................t..............p..phshshhs.s.shuh..hushh..........................................................	0	118	172	253
+141	PF02861	Clp_N		Clp amino terminal domain	Bateman A	anon	Pfam-B_102 (release 6.0)	Family	This short domain is found in one or two copies at the amino terminus of ClpA and ClpB proteins from bacteria and eukaryotes. The function of these domains is uncertain but they may form a protein binding site [1].	20.70	7.40	20.70	7.40	20.60	7.30	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.23	0.72	-4.03	167	16656	2009-09-14 13:11:56	2003-04-07 12:59:11	15	55	4576	80	4358	12959	3258	51.20	24	11.11	CHANGED	A.pphApphscpalssEHLLluLlppspuhstplLpphGlshpplcptlpphhs	...................Atp.Apphsc.palssEHlLluL....l.......c....p....s..p.......u........s..s......s....p..l....L..p....p.h...G.l.s..h..p.pl.cpt.lpphh.................................	0	1453	2953	3792
+142	PF02353	CMAS		Mycolic acid cyclopropane synthetase	Bashton M, Bateman A	anon	Pfam-B_862 (release 5.2)	Family	This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyse the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.72	0.70	-5.32	12	4148	2012-10-10 17:06:42	2003-04-07 12:59:11	15	22	2427	44	1236	14323	7479	263.10	35	68.06	CHANGED	pchcpphcslptHYDlSsDFFpLaLDPohTYSCAYFcc.......sDhTL-EAQhsKlDlhLcKLpLpPG.pLLDlGCGWGuhhh+AspcYDVpVlGlTLScpQhphspptlsphshtcphclhLtsac-hs-....hD+lVSlGhFEHh.......Gh-pYssaFptsapll.ssGhhLLHoIsshc.cphs.tth..........cFIsp.IFPGGpLPolptl.p.pspcsGFplhchpsLp.HYAcTLchWs-sLptph-cAhsl.huEchhchahhYLsuCAttFRhGhlsltQh	......................................................................................p...ppshpsl.ptH.Y...D...l....u....N..-...a..ap.h.a..L..D.s.s....M....p..Y.S......C..Aa...a....c.s......................................s..c...p....o....L.....-...p...A....Q............s.....K..l....c...h.......l....h......c...K.....L.....p.....L.........c.......P......G.........t......c.....l.....LDI..G..C..G...W...G...u...h.....s......h...h...A.....A.....c.....c.........Y......G...s....p...V...s..G.......l.......T......l......S.p......-......Q....h.......p.........h....u............p.......p.....+..........h....c............p......h.........s......h......t..........c.........p..........l...........p.......l.......h.....L......p.....D...........Y......R........-......l.....s..s.................pa..D..+.......I....V......S.....l....t...M..h...E...H..V.......................G...h.....c.....p.....a....s...s....a....F....p...p...l....p...c...h.L.c.s.......s...G..h..h..........l........l......H.....s....I....s....t..t....c......p....t....h...t...s............................................sa.....I..p...+...Y.....I......F.....P......G......G.....h.....L...P.....o.....l.....p.....p...l...h.....p...........h......p...c...s.......s.....h........p.....l......p...c.h....c..s......h....t....h....H...Y......s......c..T.L.pt..W.......tcp..ap............s.......p...h...............s..................c............l....h...................t............h........h..............s...........-........c........a........h.......R........h....W.ph....Y....LsuCssuFct..t.tlplhQh....................................................................................................................................................	0	353	757	1043
+144	PF00780	CNH		CNH domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.79	0.70	-4.98	62	1933	2012-10-05 17:30:42	2003-04-07 12:59:11	17	73	285	0	1105	1799	2	265.10	21	23.92	CHANGED	sssh...stspplllG.T-pGlalhsh.............t..ht.sphhph.t......lpQltVlpphslLlhl........u......s....cpLhsasLssLpstp.........t.....................plsts+ssphhs...........sshstsphLssuh+p.....slhlhchhp.shppht......................chhp-..hths................s.shslphh.......csplClGs...........ppsFcllsls.p......sts..tslh.p.sstt..........h....tthpslshhpls.......p.s...chLLCasphuhaVst...pGt......psc....shtlpWss...tPpuhsh.htsalluFps.sh.lElRslpss.....cl...hpplssppl+hlssss	............................................................................................................................................h......t...lllG.s-.p.G...l...hhhph........................................t.sph..p.hhs................hpQltl....l..pt..s........l.Llsl................u...................................s......pplhha.LstLpsp..t..............................................................................................pl.schc.G.sthhp.............hsth....pt....h....p........h...L..s..sAl+p.............plhlhp.h..t.....t...s..htph..............................................................p.hp-...h.p.hs................s.shslshh............p.p...lslGh.....................................sss.Fp..hl.sls..p...............uss.....slh.....sp.p..........................................t..h.....p..s.h...t.lh.pls...............................p..s........chL.l....s....a.....s.....p....huhaVst.............pGc....................hsc......p..lpW.s.t.........h.Pp.u...h..............s..h...t.........t......s.......lhu.a...tp....pu...l-l+.s...lpss......pl........hppht.h.pphphh....s...............................................................................	1	320	476	785
+145	PF00027	cNMP_binding		Cyclic nucleotide-binding domain	Sonnhammer ELL, Finn RD	anon	Prosite	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.62	0.72	-4.17	342	26013	2009-01-15 18:05:59	2003-04-07 12:59:11	24	502	4562	267	10760	22035	3366	90.20	18	23.38	CHANGED	hpphptGphlhppG-....sstlallhpGplclhptspssp............................hthhtsGshhGchshhtsp.........tsssshA.....hsssplhtlsppphpplhpppsp	.......................................................h...httGph.l.h..p...p.......G.-...........ss..p...h.......ah..l.h.p..G.......p......l..c......l...h.t.t...s...p..s...s.pt......................................................................................................hht.hh.t..s....G....s.....h..h..G...c......h....u..l..hpsp..........................psss.spA.............hs.s..s.p.l.h.tl.s.t.p...phpp..lhtp...t.........................................................	0	4474	6939	9042
+146	PF02629	CoA_binding	DUF184; 	CoA binding domain	Mian N, Bateman A, Griffiths-Jones SR	anon	COG1832	Domain	This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.99	0.72	-3.47	70	6798	2012-10-10 17:06:42	2003-04-07 12:59:11	14	37	4404	64	1756	6726	3805	96.70	32	28.56	CHANGED	scpsclhlhGhosp..phs.aphppthphshp.hlhulsPp.csG.pplt.........GlPlatslc-hhcch......t..sssulIhV....PushAtcsl.Etlc.Asl+slVslo.G	.......................................cpo+Vll.G..ho...G....p..pth..a...+.s....p...p...t....h....s......h.......G.......sp....hlh..G...l.sPt...+....s....G....p.p..ht..........................................GlP.V...a...s..s..l.c...-..shpph....s......ss.sulIhV......P...s...sh...s...t...c...ulhE.ul.....-..AslchllslTtG..............................................	0	610	1119	1487
+147	PF01144	CoA_trans		Coenzyme A transferase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.19	0.70	-5.16	43	6881	2012-10-04 00:26:15	2003-04-07 12:59:11	18	14	2405	102	2146	5554	1112	208.60	24	73.96	CHANGED	hpphspAlu.plcDGthlhlG....hG.hP.sLlsslhcps.....hsshshlpsss..Gh....hGluslhhstplccsl....ssh.hsp.......shhhspphhsuph.phchhsQGshh-thhhGGstls..u.lsssslG.shhttt......................phhshs..........Gtthllptuhpsslshl+ttptDthuplhacsostphs.shhs...........sthlT.hpV.cls...hsph.s.phhhPGlhl-pllts	..................................................................................h..phtptlu.tl....pDGthl.s.....l...G........hG..h.........P......sLl....s.s.l.h..pp.......................psh.shl.psps.....Gh...............hG.l.G...h.......h...p.p..t..p....l..cphl..........ssh..ssp.............shhhspt.hhs...u...p...h....ph.t.hspGs...hs-hhh.hGuht.....ls..G.lss.h.u...l...s...s.htst................................................................................pl.h..s..hs.................G..t..h...h.L.h..t.t....u..h.p.h.s.l.sl......h..c.t.pp.s....Dt.....pu.....plhh....c....psh..h..s......sshs.......................shlT.lpV.c..ls........h.s...p...h.......s....p...hhPGlhV-plh..t..................................................	0	620	1257	1756
+148	PF02514	CobN-Mg_chel	cobN-Mg_chel; 	CobN/Magnesium Chelatase	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_647 (release 5.4)	Family	This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid [1]. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis [2].	18.40	18.40	18.50	18.50	18.20	18.30	hmmbuild  -o /dev/null --hand HMM SEED	1098	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.88	0.70	-13.70	0.70	-7.17	129	1875	2009-01-15 18:05:59	2003-04-07 12:59:11	11	21	1069	0	690	1853	1652	877.50	30	85.15	CHANGED	lhpYhttGG......tcNhpshlphLspph..........thts..........tsPhthPp.h.GlY+.st.........thhtt.t.h.t.....................t..tssVGllh.aRuhhhuushshhDul..lcsLEpcG.hsslslassu.........tstst..ltphhht...........tlD.sllshsuFulsssss.t............uhphL.ppLsVPllpslhh..hpohcpWpsuspGLs..sh-luhpVslPElDGtltsh.slut+pt........s...t..h.....tthtPhs-Rlchlss+stpalpL+cpsss-K+lAlllaNaP.sp..pupl.GsAs...hLDs..sSlhplLptLpppGYsl..........s...lPps.scpLhctlh.tthsss..h.st.t.h.p......hh.hshpcYhpaasp...Ls.thppclpppWGssPG..........t....hlh....t...............hhlsGlphG.NlhlulQPsRG.....hpt..Ds.h...phhHssslsPsHpYlAaYhWLcct.....apADAllHhGsHGoLEaLPGKplGLSssC.aP-hllGslPplYsYhlNsPuEGs...AKRRutAsllsHLoPPlspAuL..YssLtcLcphlccYppst....t.sst..ctptl...tppIhphsp.phsLsp.-...........................................................................................................................shtphlsp..lcs...aLp-lcps.IspGLHlhG..psPp.......s-ph...sphlhshhphs............sh.t..h.....................................thtttphhphlpthstth......t..................................................................................................................................................................................................................................................................................................................................................................................h..hh.thh.tl.....ssspElsuLLpALsGcalsPGPuGsPsRs..-lLPTGRNhauhDPptlPopsAaphGpchA-pLLc.cahp-p..Gc..aPcslulsLWGossh+otG-slAQhLtLlGV+P.....laD.ssGRVsslElIPLs-L.........GRPRIDVslplSGlFRDhFPphlpLlDcAlphlAs..................h.D.Ess-.Nhl+ppsht..............t.t.s.....p.uthRlFussPGs..YGu.G.lsthl-uu.sWcscs-Lu-sYlstpuaAYG.......t.s...s........tu...........p...pspc................shcptLpsl-sshpsp-opE...hslhDsDcYapahGGlstAlcpls..Gp.pPshYhuDps...pssps+l+oLp-pls+.hRoRlLNP+WlcGMhcHGYcGAtElutpl-thaGasATs.stVscahacplscsalhDcp...hpcalpp.tNPhAhpshspRLLEAtpRGhWp.sssphlc	..................................................................................h...ah..Gu.......tNhtthh..hh.t.h......................................s..hs..t......u........l..ht..........................................................................................................tts.hlullh..+shh.ss.s.hshhp...slhptl......ct.tG.hps.lslas.u...........................t.............l.ph.h.t.....................ss.hlls.hh.t....hs.hss.......................t.thh...tth..s.hP.l.hpsl.......htshttW.t...t...s.....pGls.......sh...phshpls.l.PEhDGtl.sh.shuhpp................t......h.......th.s..cRhthlsthshpahpLpphsstp++lAllhhsaP..s.......t.....psplusu..s....hLDs..t..S...hhtlLpthp..ttGYpl.............t.......h..........P...............t.................s....sptLhp.lh...........s.....s...............................hsht...pY.th..htt...l....thtpth....tt.WG.s.s...............................t......hh..........t..tt.......................hhlsuhphG...NlhlhlQPstG........ht.t....ss...t.hHs...shsP.HtYhAhYhWlpp..............................atu-AllHhGpHGsLEalPGKthulSt.t.C.aP-hhlGslP.lY.ahsssPuEus...AKRRuhA..sllsalsPPhtpAth..Yt.t.ltcL.cpllsca.ph.........sst......ch..l..............tppIhph..ht..thtlpp-h............th...............................................................................................................................................t.thltc..lcthLt-lcp.t........l.tGLHlhGps.s.p.......s.pt.h...hthlhshhp..................sl..............................................................................................................................t....ht.ht......t........................................................................................................................................................................................................................................................................................................................................................................................................................h.....hhtt.h..h.tl...tsstEhtslhpuLpGtal.suPuGsPhRs..plLPTGRNh.auhDsptlPo.hAhphGhthAppllp.pahtc........p..Gp.aPcslulslWGossh+otGpsl.AphLhLhGlcP.....hhs..st............tRl.......s.sh.cl.ls.....tpL......................sRP......R.l..DVslp.lSGhFRDhFs.p.hthlDpAlphsAt...........................................h...-.Es.c.N.ltt+s.t...................................t.s.................ptuthRlFustsGs...Y.Gu.G.lpthl-s......t...tW...........ps...............ct-....Luc.sahshtuaAYu..............t..t................u...........t......ttt.........................hhpttLpphphshps.-spE...hslhsss...caapa.GGhhtsspthp...........G......p...t.......st....h......a..hsDp.s...p...pp..sphcslp-phth.hRs+hlNPcWhpuhhpHGYc.Guh-h.s.t.pls.hhGa...........sAT...s.thl.....s...sahap.tltpsalhD.t...hpphhtp...N.PhAhpphs...t+hlEA.pR......uhWp.ss.p...t............................................................................	1	220	463	581
+149	PF02492	cobW		CobW/HypB/UreG, nucleotide-binding domain	Bateman A, Mian N, Bashton M	anon	Pfam-B_428 (release 4.0) & Pfam-B_1247 (release 5.4)	Domain	This domain is found in HypB, a hydrogenase expression / formation protein, and  UreG a urease accessory protein.  Both these proteins contain a P-loop nucleotide binding motif [2,3]. HypB has GTPase activity  and is a guanine nucleotide binding protein [3]. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression [1]. UreG is required for functional incorporation of the urease nickel metallocenter.[4] GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins [1]. This family of domains also contains P47K (Swiss:P31521), a Pseudomonas  chlororaphis protein needed for nitrile hydratase expression, and the  cobW gene product (Swiss:P29937), which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans [5].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.41	0.71	-4.83	62	9942	2012-10-05 12:31:07	2003-04-07 12:59:11	14	44	3597	7	2693	11049	3134	177.40	27	56.79	CHANGED	sshslsG.lGuGKTTLLpcll.....pp...h+lAVIhN-hs..sshDuphl..........pps..ss...............llplssGshCpo.lptDh.hslpsltcht.......................................phDhllIEssG.lssPssh......................shthDshls....llDs.........................scscchspph.ptlthADllllNKsDLssts.tshcthtpphcplssptpllh	......................................................................................................................hhllsGaL.......G...uGKT....TL...LpclL........................p.pps....h.+lAV...I..h....N.....-.......hu.....t......s.....s...l.D.....u.....p.....l....l.......................................................tps......ss.....................lhp.l.s...s....G......C...h.....C.C....o.....hp.......t....D....h....h.s...l.p.s....l....hcht...............................................................................................................................................................ph.D.....h.l.l.....I....Eso.G....lsp.P.s.sl.......h.....................................h.........h..t..l......c...s......h..l.s.........l.lDs....h...........................................................................................sp.t..p..s...h..s...p...h.h...h..p..Q..l...t..h..A...D.........l.........l.........llNKs.D...L..ss.....t.......p........p..thp...p.th.p.p.lsspt.h..t.....................................................................................................................	0	789	1689	2240
+150	PF00135	COesterase		Carboxylesterase family	Sonnhammer ELL	anon	Prosite	Domain	\N	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	535	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.71	0.70	-5.80	123	8736	2012-10-03 11:45:05	2003-04-07 12:59:11	23	92	1650	371	4719	13851	2441	405.50	22	85.47	CHANGED	hhhhhhhhhhhhhhhsstss.........................ltst......GplcGh.hts.tt.....t..h.sFhGIPaAcPPlGpLRFctPpP.....sps....W.pslhcuophsstChQ.sphh...................hpsshs...................SED.CLYLNlasPphspps............................................hPVhVaIaGGuFhh..........Gsu........s.hsusthhhpcsVllVohsYRLGshGFLohsspphs......................GNhGLhDQhhALcWVppNIssFGGDPsplTlFGcSAGuuSVshhhlS..........ts...cuLF++AIh.SGsshssas.hpsss..hphspplApthGCsssssp..................plhcCL+.ptsspcllsspt..hhhthhshhs...............hhP.............sl-us..................hlscpP......tphhppu.hp.plshll.GssppEGhhhhshhhtt.tt.........t.p...................................hhphhtthhh.hspht........tpplhptYhss.pt..st.pph.pthtplhuDhhahts.hhthhtphppsssss.YhYpFsapss........hthh.thtsssHus-ltalFstshhtt.th.........................ppcctt...cphhphassFApsGsP...............s...t.stWsshspp.....t.hthhhtstpthhtpp.......hpaa	..............................................................................................h........................................................h..h.........u.h...G.................................................h...........ahGlPa.A.tsP..h.....t....................................R.a.......t......................P.....................................h.....p...t.......h......p....s.......p.....p..................s........s..........s.Q.................................................................................................sE...D...C...L...h..L........N..l..a..s.P..t......t..t..tt...........................................................hP...V.hla.........l.....a................G.G..u..a....................................Gsu........................h..t.....s.....t...........h.....h.............t......t......s......l......l.....l......Vohs....YR.....l......G........h.......h.............G....F.....h...s....h......s.....t.t.............................uN..h.....G.......l...h........D....Q......h....h.....A.L....p....W..l........p........c.......N........I..t...........t..........F.........G............G...........D....P............p...p..l..T................l....h....G.p...S.A.......Gu........h...u..l..t..h.h...hhs....................s.s...............ps........L...F..........p...p..u........I..h......S...............G..........s.........h...h....................................h.....h..t...................thh..th...s.....p.....h..s.ht....tt...................................................hp.p..L....p...t.h.s......p..p...l..ht...........................................................P...........................................h.l.-.s......................................................hls...p.......................th..h......t.......t.......t.............h.............p...........h.......s.......h..hh...G......s.p....p..Es................h..h.h..........................................................................................................h..........h....................................t.h..h......a........t.................................................................................................................t.h......t...hhs....-..h......h.h.....h....s.........................h............................................h................t...........t.............................t....t..............................ahY.ath.s.................................................................t.s..H.s..-..h....hh...a..t.............................................................t..h.......t.h.thhhs.Fs..t..t..s....ps...........................................a....................................................................................................................................................................................................................................................................................	2	1694	2505	3925
+151	PF01484	Col_cuticle_N		Nematode cuticle collagen N-terminal domain	Bateman A, Bashton M	anon	Pfam-B_200 (release 4.0)	Family	The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see Pfam:PF01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins [2].	20.80	20.80	20.90	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.38	0.72	-4.28	113	1198	2009-01-15 18:05:59	2003-04-07 12:59:11	12	22	21	0	1054	927	0	51.90	23	16.32	CHANGED	hss..usshSslullus.llslshlasplpshpsplps-hpth+spuc-hWs-h	.....h..shhusshSslAllss.llslPhlashlpplpsplps-lshh+sp.......u...cshWpch...........	0	359	519	1054
+152	PF01391	Collagen		Collagen triple helix repeat (20 copies)	Bateman A, Eddy SR	anon	Swissprot	Repeat	Members of this family belong to the collagen superfamily [1]. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix.  The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline.  Collagens are post translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-11.88	0.72	-11.88	0.72	-4.43	41	44425	2009-09-12 04:47:45	2003-04-07 12:59:11	13	899	1492	46	19240	35044	5977	63.30	39	36.42	CHANGED	GssG.sGssGssGssGssGssGssGssGssGssG.sGsPGssG.sGssG.sGssGssGts	.............................................................................................G........G........s......G................s.....G.....................G...............t......G...........s.....G..............t........G............s......G...............t......G....s....t......G................t.......G............s......G........s.....t...G.........s.....G..........s....G.................G........G..G..h............................................................................................	0	3964	5810	11551
+153	PF03772	Competence		Competence protein	Bateman A	anon	COG0658	Family	Members of this family are integral membrane proteins with 6 predicted transmembrane helices. Some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA [1,4]. These proteins may transport DNA across the cell membrane. These proteins contain a highly conserved motif in the amino terminal transmembrane region that has two histidines that may form a metal binding site.	20.20	20.20	20.30	20.60	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.75	0.70	-5.34	123	4251	2009-01-15 18:05:59	2003-04-07 12:59:11	11	14	4131	0	907	3604	477	262.70	21	39.09	CHANGED	LlhG-+s.tlspphhptappsGlsHLlAISGhHlullss....hhhhlhphh................hssptht..hhhulhhhhh...Y.shlsGhss.sshRAhlMhslhhhuhhh...t+c....hsshssLshuhhllL.lhsPhslhssGF.LSFhAlhullhhh........thhpphhthhthhhh............................sshss...plssh..PlhhhhFtplSh.hullsNLlsl.Pl.huhll....lPhhlhuhlhhhh..............shuthhhh....hh..th......lphlhthh.phhup........hsh.....lhh..stsshhhhhhhhhhlhhhhhhhthh	..............................................lhhGc.p.p.tls.p.c.......h.pphhppsGlsHLhAlSGhHluhhhs.......hhhhl.httl...................................................h.s.ptht........hhhshhhhhhY.s.h.L.sGhss...uslRAhlhhs.lhh.h.h.h.hh........t.p.p..............hs.shp.s...lshshh.h.ll.lhsPhhlhshGFhLShhAshsllhhh............................thh...t.h.hth..h......hh..h..............................................................................hs.hsh.plshh..PlhhhhFtphsh....hu.......hls...Nllhl.Pl..hshlh...lPh...hlhshlh.hhh..........................lsthhhh.................................hh......shh.......hthlhh.h...l....phhsp..............h.........hhh...s.t..sh.hhh.lh.h.hhhhhhh.hh.....h.........................................................................	0	309	604	770
+154	PF05071	NDUFA12	Complex1_17_2kD; 	NADH ubiquinone oxidoreductase subunit NDUFA12	Bateman A	anon	COG3761	Family	This family contains the 17.2 kD subunit of complex I (NDUFA12) and its homologues.  The family also contains a second related eukaryotic protein of unknown function, e.g. Swiss:Q9BV02.	21.30	21.30	22.00	21.50	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-11.06	0.72	-3.57	88	843	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	595	0	467	747	993	102.70	29	67.27	CHANGED	GphVGcDchGNpYYcst...........stc+RWVlYs.uhs.......E..ASpVsP-WHGWLHaphDpsPo...pp.shst+sWpc..sHp.NhT.GTstA..YtPtG.....uh.....t......psh.ptD.YcAWsP	..................phVGpDchGNpYYEst...............pthhtp+RWV..Y..s.stt............-........uopl..P......P..pW...........HuWL+at..t-pP.Po........pp...t...h...t.......c...p.a.pp....+.p..Nho...so...tt..Yhs.s......................................................................................................................	0	150	256	364
+155	PF00329	Complex1_30kDa	complex1_30Kd; 	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	Finn RD	anon	Prosite	Family	\N	21.10	21.10	21.30	21.70	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.32	0.72	-3.78	131	5889	2009-01-15 18:05:59	2003-04-07 12:59:11	14	20	4153	16	1220	4082	2058	105.60	34	33.03	CHANGED	plhphL+pp...thshLsslsusDhhptt........chplsYp.lhsh.....tpspp........ltl+stl.st..cssplsSlsslasuAsahEREsaDhaGlpFpG.HPc......h+.Rllhs.-s...a.s.......aPLRK	.........................................................hLh........tashLh.slsuhDhtsts..................caslhYp...Lh.s.h......p.p.s.pc....................lpl.K.l.....hs..st...........ps............s......p.......lP...Sls..la..uAsWhEREsaDMaGIhasG.HP.c........L+.RIl...h.s..ps...W.G.......aPLRK..........................	0	403	782	1023
+156	PF02950	Conotoxin		Conotoxin	Bateman A	anon	Pfam-B_529 (release 6.4)	Domain	Conotoxins are small snail toxins that block ion channels.	25.10	25.10	25.20	25.10	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.34	0.72	-3.18	112	926	2012-10-01 22:06:18	2003-04-07 12:59:11	12	1	54	27	2	953	0	70.10	26	96.65	CHANGED	hKLshlhllslLLlo.......ss..stsspt.sp.......p.tpthpphpssp..pphh...ptp..h.....................hsppCCsh.....hC........hCh	........................KLss.lLhlslLLhs.....hsshthsu-pssc....................p.scp.t.p.chpssc....p.p.th...hh..........................htppCCsh......hCt.......h.sC......................	0	0	0	1
+157	PF05019	Coq4		Coenzyme Q (ubiquinone) biosynthesis protein Coq4	Wood V	anon	Pfam-B_14948 (release 7.6)	Family	Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway [1].  The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).	20.50	20.50	20.50	20.80	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.36	0.70	-5.44	27	475	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	363	8	319	505	118	198.00	31	79.73	CHANGED	YsuHlPL....sshp+hhLssGSulsulhcPcR.uDhIAsLGEsTuh.hhLppL+cpMhsDspGRpIL+-+PRIoopoLshstLpphPcsThGtsYspaLccpsVoPDoRssV+alDD.EhAYVhpRYREsHDFhHslhuhPhsh.GElAlKhhEhhNhGLPMshLuulhushRL+spp+pphhphYlPWAl+sGhpu+.......sLlNVYWEchhEpDls-LRcELGIp.sPc	............................................................................tph.hhhhuuhhu.hh.pP.c.tp.....l.shhuE.so.uh...hl..phh.ppMhpsspGpplLp-+.Pclssps...l...........s..hstL......ps.L..Pps...olG........tsYhpaLcp..............ps.lo........P...D........s.........R.s..s......l........c.......a.l....-.....-..........-......h.....A..Ylh..pRaR-sHD.haHslh.G.hs.h.s.h.....GElulKhhE...hh........p...h.......t..l......P.......h...sh...L....s.....ul...h.u...s.h.......c.........L............p.....t...p..t.p...........t........h........hp...........h.h..l......P...W....A..hcs....G....hp.u.c..............lhslhaEc.hh-pslpclRpcLsIp............................................................................................	1	90	172	272
+158	PF03471	CorC_HlyC		Transporter associated domain	Bateman A	anon	Bateman A	Domain	This small domain is found in a family of proteins with the Pfam:PF01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux.  The function of this domain is uncertain but might be involved in modulating transport of ion substrates.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.46	0.72	-4.20	174	11377	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	4360	35	2334	7354	2259	80.60	23	18.84	CHANGED	pphssssallsGphslc-lpchhsl.p....lsp.c..c.....hc.TluGhlhpplsclPp..G-......ph........p...s...............hp.hpVhchcsp+..Ipplclphhp	....................................p..hscssallcGpss.lc-...l.sch.h....sl..c.........ls-..-............-..............hc..TluGhl...hp..tl...s..c.l.Pp...hG-.......pl................p....s..................................hp..hplh....ch.-.sp+....lpplplph..t................................	0	682	1425	1903
+159	PF02389	Cornifin		Cornifin (SPRR) family	Bateman A	anon	Pfam-B_1215 (release 5.2)	Family	SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteristic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid [1]. 	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.63	0.71	-12.31	0.71	-4.54	5	373	2009-09-13 06:27:35	2003-04-07 12:59:11	10	30	87	0	232	424	33	118.10	16	44.10	CHANGED	cQHQVKQPCQPPPQEsFVPp.TKEPCHocVPpPGNT........................KlP-sGsThV.EsshT........................KVPEPspTKVPEPCpoKVPEPspTKVPEPCsTKVPEPsYPKVPEPupsKVPE.G..................................PsHsKsPEPGasKVPEPGhPKVPEPCQo+VPEPCPSTVTPusAQQKTK	................................................................................................................................................................................................................t........th.tst.....st.hs.t....t.....th.p....st..ts..ths..t.t.....th.t..st........th.s..t....t....th.....t..................................................................................................................t.................................................................	0	106	118	167
+160	PF02628	COX15-CtaA		Cytochrome oxidase assembly protein	Mian N, Bateman A	anon	COG1612	Family	This is a family of integral membrane proteins. CtaA is required for cytochrome aa3 oxidase assembly in Bacillus  subtilis [1]. COX15 is required for cytochrome c oxidase assembly in yeast (Swiss:P40086).	21.50	21.50	21.50	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.24	0.70	-5.55	146	2337	2012-10-03 10:28:09	2003-04-07 12:59:11	10	13	2048	0	837	1935	3330	287.80	24	85.08	CHANGED	thhhhhshhhshsllllGuhTRLTsSGLuCs-.WPsChGt..hsPhsptp.............................hth....ahEahHRhhuthlGllhlshhlhsh.............h.h.h...tthh.hh.shhlhhLlshQuhlGhhhVp.s....l...............p.hh.lssHLhhuhhlhuhlhhhshphhth............................hsh..tthphhshh.sls.llhlplhhGu..hluu.pAuh.ss...................st.h..h..................t.h...........................phhHRhhAhlshhhhlhlhhhhhhtt.........tthpphuhhh..hsllhh.QlslGlsslhh.tlPl.h...lulhHphsAslLlsshl	.........................................t.hhhhhsshhhhslllhGuhs..RlTsSGLuCss.W.PhCt.Gt...hsPhstt.t.................................................................hphhhEasHRhhuthlGl.hhlhhslhsh..............................................tt.tth......tpphh...hh.shhhhsh.lshQ...............uhl..G...hhs..VthsL.....................................................................sshh...lu...h...HLh.hu..hl.h...hus.hh.h.hshtlhp.....................................tp.hh..tth+..h.h..s....hh.hhh..hlhlt.l...h....h.Gu....hV..uu....p...A.uh.sh...............................t..h.h...........................h.....hp..thl..........................................phsH.RhhAhh.shshlhhhhhhshpth..........................tthtthshhh..hhllhl..Qs.hlG..lhslh.........h.....tls...........l...h............lu.hhHthhushLhshh.h...................................................................................................	0	262	541	716
+161	PF02936	COX4		Cytochrome c oxidase subunit IV	Bateman A	anon	PSI-blast P00423	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium member of this family is called COX VI Swiss:P26310. The yeast protein Swiss:P53077 appears to be the yeast COX IV subunit.	23.50	23.50	23.60	24.00	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.77	0.71	-4.45	10	463	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	283	51	246	436	0	129.20	29	76.99	CHANGED	chVuptshupPshsDl.-pWtshsp..pEpssllssLR-+pKssWpsLSh-EKKAlYhISFspphsc.httssGEhKhlhusslhslulohslhslh+hhshPphP+Ths+EWQcussEhhhspchNPlsG.huptYchcsph.p	.......................t.t..u.shhhshp.ch..s...........p.-...ss.hpsL+-+pKssWppLohpEKpAhYhluFspphsc....hpt.sssEhp...plhs.ss..hhhluhohhlhhh..+ha......s.h..s...P.pThsc.E.Wpttp.chhh...s.hphNPlpG..uttashpt.....................................................	0	62	111	185
+162	PF03626	COX4_pro		Prokaryotic Cytochrome C oxidase subunit IV 	Finn RD	anon	Pfam-B_3217 (release 7.0)	Family	Cytochrome c oxidase (COX) is a multi-subunit enzyme complex that catalyses the final step of electron transfer through the respiratory chain on the mitochondrial inner membrane. This family is composed of cytochrome c oxidase subunit 4 from prokaryotes.	25.10	25.10	25.20	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.75	0.72	-3.89	250	2280	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1772	0	517	1230	725	81.10	30	74.43	CHANGED	ahhsallhllLTs..lshhls...........................hts.......hh.s.hshshsll..hh.lAhlpshlhlhaFMHlpt.spp.........hhphllhshllhsslhlhh	........hhGFlLullLTl.lsFhhs...........................hts.......sh...o..ssh..lshl...ls.hAllQshlpLlhFhHhsp.psctt.p....hhthlFsll..l..lsh.lllG.olWlh................	0	131	290	402
+163	PF02937	COX6C		Cytochrome c oxidase subunit VIc	Bateman A	anon	PSI-blast P04038	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.	21.40	21.40	21.40	22.60	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.37	0.72	-4.09	8	161	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	101	51	89	163	0	69.70	43	80.44	CHANGED	ushLsKPQMRGLLu+RL+hHlVsAFlluLGVsAhaKFusA-PRK+AYADFY+NYDAMK-FEcM+cAGlFQSVK	..........s...lsKPt.MRGLLs.+pl+hclssAhslo.lssusha......KasVs-.PRK+AYADFY+NYDuhK-FEcM..+c..AGlFpSs..............	0	23	28	53
+164	PF02935	COX7C		Cytochrome c oxidase subunit VIIc	Bateman A	anon	PSI-blast P00430	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII Swiss:P04039.	25.00	25.00	25.10	25.00	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.21	0.72	-4.17	14	253	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	202	51	155	269	0	68.00	35	72.16	CHANGED	Mlupp.....sRRssspulRt.+...........atpGPsp.........NlPFpVpN.KahlhshhhsFhusGFusPFlllcaQLhKp	.............................tpt.....sR.p.h.ss..s...s.h..Rt.p.................asEGPtp............NLPF....s..l.....ps..K.ahhh..hhahsahusGF.usPFh.ls.haQhhK...........	0	42	76	124
+165	PF04516	CP2		CP2 transcription factor	Mifsud W	anon	Pfam-B_2156 (release 7.5)	Family	This family represents a conserved region in the CP2 transcription factor family.	25.00	25.00	28.30	28.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.70	0.70	-5.31	29	661	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	171	0	367	552	0	208.40	37	38.82	CHANGED	oh..p.p.h....h.shhs.tspphshst............tpphcFphsLpAPTAhhp+tsE.PlTYLNKGQuYslolh-s..ss.sshpssp...hR.ohlRlsFc--cpppc.tppWphW+.......u+Q+suK.psl-hsDhpp.......shsplp.lEpsua..suhsVhWssst.s...EssIhlphNhLSTDFSppK..GVKGlPlRlphcT.hhss..........tssssctschsaCpVKlF+D+GAERKlpsDht+lpKphtKh+	......................................................tttpt.......................................ttspt.sFpYsLpAspS.t.K.t-tshTYLNp...G..Q.Y...t.l.plh-s..tt..s.t.htthp...........V+.SllhVVFc-c+.p...p.phpphchW+........pp.s....pRllDl.D.h..........Shshl.p.......hp.psu...NulpFhWsssc......cspl.FI..pVp.C.lST-..FospK..G...KGlPh....plQIDTap.sp................................p.sc.lHpA.CQIKVF.p.sKGA-RK.h+s-ccKhpK+psp..t..........................	0	66	102	219
+166	PF00118	Cpn60_TCP1	cpn60_TCP1; 	TCP-1/cpn60 chaperonin family	Sonnhammer ELL, Finn RD	anon	Prosite	Family	This family includes members from the HSP60 chaperone family and  the TCP-1 (T-complex protein) family.	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	485	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.32	0.70	-5.88	94	23232	2009-01-15 18:05:59	2003-04-07 12:59:11	19	54	11481	758	4711	17190	6810	316.10	36	86.46	CHANGED	lu......chlpooLGPpGh......sKhlhp..tstphhlTsDGsoIlcclcl.pcPs....AcllhpsupspscpsGDGTTosllLsspllppu.phl...pt.GlcPpplhcGhchAhptslchL......pph..shpsp..............pplhplupsuhsu+..........phlupllscAl...h.............................hclsp....ltlhphpsuph..pcoplh..cGlh.l..c+shhss.......ph.........pph...css.plllhstslph..ps.........t..hts.tth.th.t.p.t.lhphlcplhcts.hsl.................l......lspcsl.....ss.uhphLspsslhulpcl............ccpplccluhhoGup.hlsp..............tslp.s.s.......LGpsppl....plsp..cphsh.lp................................................s...................hsspssolllpGsopthlcEhccslcDAlsss+sslc..tst..llsGGGss.hpluptL.........chsps............hssc.........pph....ulchhupALcths+tLApNuGh.ss..........hpllsp.lps..............tpsp..............thGlshtssp......hh.D.hhptG......llDshpVpppslptAspsAs.hlLplDplltstp	..........................................................................................................................................................................................................................................................................................................................................................................To...........AT..VL......A..p..u.l.lp....E.G.h+.sV....................sA...Gh.......NPh.....s..l.....+.R..G..I-.+.A.l......tssl..cpL....................cph.u.h...spsp................................ctIA..pV.usl.SAssc......................................p.p.lG..p..l...IA-AM..................................................................cKVGp........-GVITl.E..-.ups..................-...p..Lph........sEG.Mp.F......D+.GYlSsYh.............................pph................t.htl.........-sP.aILlh...-.c........K.lSsh..pp....................................................................................l..l..sh.L.-.tlh....p.tu..ps.L.............................l.........Il.u.-.......c.l........-s-AL.s.sL.....l.h.N.....p.h.p..uhhp...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1615	2762	3850
+167	PF02787	CPSase_L_D3		Carbamoyl-phosphate synthetase large chain, oligomerisation domain	Griffiths-Jones SR	anon	ref [1]	Domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  	25.30	25.30	25.30	25.80	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.40	0.71	-4.35	95	8742	2009-01-15 18:05:59	2003-04-07 12:59:11	14	76	7559	40	1436	7541	2587	120.70	43	14.93	CHANGED	lhp.p...LppPsspRlahltcAh.+pGhol-claclT.pID.aFLpplcpllphE.cplpp.....hth.sp.......hLpcsKphGFSDppIA....pl.......h..st........scpplRph.RpchslhPsaKhVDTCAuEFtu.pTPYaYSTY	......................................pcLpcPsDcRhFhlAs.......Al......+t....G..a..o........l-cla...-LT.KIDhW.FLpKhcpIlchp...pp......Lcph...................pslsh-...............hLppAKphGFSD+pIA......th.....................................h......ps...........................oEhs.VRch.R.c..c.h..sI.pP...hhKplDTsAAEasu...sTsYhY.TY................................	0	471	910	1212
+168	PF04969	CS		CS domain	Finn RD, Fenech M, Eberhardt R	anon	Pfam-B_1217 (release 7.0)	Domain	The CS and CHORD (Pfam:PF04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD [1]. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies [2]. Two CS domains are found at the C-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19) (Swiss:O94966), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2 [3].	21.30	10.00	21.30	10.10	21.20	9.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.72	0.72	-3.43	100	2605	2012-10-02 21:54:05	2003-04-07 12:59:11	11	115	372	25	1627	2732	72	77.20	20	23.00	CHANGED	spasWtQo.spVtlsl.l.sss....tcslplphpp.pp...lplt.............lp.st...p.hhhpsc.LhspIss-cSpaplpss........plplpLpK	...........................................phpWtQ...ots.p.......V.h.....lpl...l.sst..............tc.s..l......p.....V...phpp...p.p.......lplp..................................................hp.ttt.......pthhh....p..h......c.....L..h..pt.Ip..s.....-..pS...p..a...plpss.........plp.lpLpK.......................................................	0	581	857	1254
+169	PF00988	CPSase_sm_chain		Carbamoyl-phosphate synthase small chain, CPSase domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_345 (release 3.0)	Domain	The carbamoyl-phosphate synthase domain is in the amino terminus of  protein. Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines [1]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00289. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.	21.10	21.10	22.80	22.30	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.42	0.71	-4.64	134	6372	2009-01-15 18:05:59	2003-04-07 12:59:11	17	41	5635	40	1365	5095	2458	123.10	45	25.61	CHANGED	hpAhLlLEDGolapGp.uhGu...p..u..pshGElVFNTuMTGYQEllTDPSYsGQIlshTaPhIGNhGlNtpD...........hE..S......p.....pstspGlll+-hspt..sSsa+up.poLspaLpppslsGIsGlDTRuLs++lRp.pGshpuhIs	...................................thLhLtDG.s.hapG..u.hG.u..............p......t.............t.sh..GEl............VFsTuMTG.YQEhlTDP...SYp..sQIlshTY..Ph...IGNhGl.ss-.D..........................................hE..S............p..........plpssGllVp-h.s.pp....sSNaR.sp......poLscaLcpcslsGIu.GIDTRtLT+hl.R-.p.G.shpGtI.h..................................................................................................	0	437	856	1143
+170	PF03178	CPSF_A		CPSF A subunit region	Mifsud W	anon	Pfam-B_1224 (release 6.5)	Family	This family includes a region that lies towards the C-terminus of the cleavage and polyadenylation specificity factor (CPSF) A (160 kDa) subunit. CPSF is involved in mRNA polyadenylation and binds the AAUAAA conserved sequence in pre-mRNA. CPSF has also been found to be necessary for splicing of single-intron pre-mRNAs [1]. The function of the aligned region is unknown but may be involved in RNA/DNA binding.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.87	0.70	-5.34	80	1132	2012-10-05 17:30:42	2003-04-07 12:59:11	10	23	315	30	802	1130	24	296.80	22	26.18	CHANGED	puslpllss........hp.........sl......s..shpL..p.p.sEtshulppsphp.spt....................t.cp....hllVGTuhshspc..sp............Gplh.lacltp...................cLchltcpcl.cGs...ssAlsth..pG+.llsuhG.pplhlaclsccp.....Llthu.hptsh...hlsslps.......h.......ss....hllluDhh.cSlthl...tapp.........-sp.hhhhucDhp..sh.lsssphL.Dt.c.ollsuDptsNlallch...s.cssps.ssp...........................+L.ppupFalGchsssh..hsll.....t.p.........................llauohpGolG..hllP.lsccshchhppLppplpsph..............slsGhs.pta.....Ruhh................s+sllDG-Llcp.......ahp	..............................................................................................................................................l.lhs..p...hp......hl...p..thph...t...t...tEhsh.......shh.s.p...http..........................................pthhhVGTuhsh..s..p.tsp........................Gtlh.laph.p..............................................................cL.phl..tcp.ph....c.ss............shulsth........pG....+.llsul....u....pp......lh...laph..spcp..............................Lh..ths.h.tph.........hlhtlpsh...................................ts.....hll.lu..Dlh.c.S.lhhl......tapt................-sp.....l..........hu.c..Dht.........s..t..h..ss...s..s..phl..Dt....c..sh.......lsuDp...................sNlhlhph..........s..s.psspp.ptp...................................................................................................+Lthhsp..aal..G....ch.ls.sh...p....ss....lh.......tpps..........................................................................................llau.T..l.p.GslG..hl...hs..l...scp..p........hchh.tl..ptp.lt..p.....h........................................................s..h...s.Gh.s..h...ta.............Rs..hh.s.......................................scshlDG-Lhppa..................................................................................................................................	1	286	462	673
+171	PF00313	CSD		'Cold-shock' DNA-binding domain	Finn RD	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.10	0.72	-4.19	40	14886	2012-10-03 20:18:02	2003-04-07 12:59:11	17	69	3908	61	3740	7958	3141	65.20	46	67.33	CHANGED	hpGsVKWFNscKGFGFIs.--Gst.DVFVHaSuIpssG.....a+oLpEGpcVpF-lpp..Gs+GspAsNVpsh	..............................pGpV..K.WF...Ns.p..K....G..F..GFIs.......s.......-..........s......G..........s..........t.....D..VFVH..a........SA..I.p.s.sG..........a.+oL......p..E.G.Q..c.............V.pF-..lpp.........Gp+G..s...p.A.sNVh..h.............................	0	1082	2120	2935
+172	PF04442	CtaG_Cox11		Cytochrome c oxidase assembly protein CtaG/Cox11	Kerrison ND	anon	DOMO:DM04116;	Family	Cytochrome c oxidase assembly protein is essential for the assembly of functional cytochrome oxidase protein.\	 In eukaryotes it is an integral protein of the mitochondrial inner membrane. Cox11 is essential for the insertion of Cu(I) ions to form the CuB site. This is essential for the stability of other structures in subunit I, for example haems a and a3, and the magnesium/manganese centre.  Cox11 is probably only required in sub-stoichiometric amounts relative to the structural units [1]. The C terminal region of the protein is known to form a dimer.  Each monomer coordinates one Cu(I) ion via three conserved cysteine residues (111, 208 and 210) in Saccharomyces cerevisiae (Swiss:P19516).  Met 224 is also thought to play a role in copper transfer or stabilising the copper site [2].	25.00	25.00	26.00	27.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.05	0.71	-4.42	135	1018	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	946	2	456	917	1462	143.90	41	68.61	CHANGED	hVP.LYclFCc.sTGhsGpTp..............t.ssstph...........ts..RplpVcFsAssssshPWcFcPpppplpV+PGEsshshYpApN.occslsGpAs.sVsPspAutYFsKlcCFCFspQsLpsGEph-MPVhFalDP-lscD.....lcslTLSYTFFcs	.....................hVPLYchhCp...sTGhsGpstp.............pttssp.............hsts.....Rp...l...pVpFsAssssshPWcFpPpppplp...............VpPGEsshshYpApN.o.scslhGpAshsV..sPtpAut.........YFsKl.pCFCFpcQpLpsGE.ph-MPVhFalDP-hspD.....lcslTLSYTFFc..........	0	129	252	360
+173	PF01148	CTP_transf_1	Cytidylyltrans; 	Cytidylyltransferase family	Finn RD, Bateman A	anon	Pfam-B_921 (release 3.0)	Family	The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast.  Sec59 is a dolichol kinase EC:2.7.1.108.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.96	0.70	-4.73	48	6283	2012-10-02 14:06:56	2003-04-07 12:59:11	15	17	4727	0	1821	4702	2431	255.40	24	86.77	CHANGED	htRhlsshhhlslhhhhlhhut..........hhhhhllhhlshhshhEhhphhthphhthhhhhs......................h.hhhhhhshhhhhh..h..hhthhhhhh.hhhhlhh.....................htthhhhhh.hhhhshhh.............................h.hht..htGhhhhlhshhllhssDshAYhhG+taG+p....hhPplSPsKTlEGhlGGhlsullhuhlhhhhht..........................................................hshhthlhlullsulhuhhGDlhcShhKRphtlKD.GphlPGHGGlhDRhDuhlhsuslhahhhhhh	....................................................................................................................................................................................Rhhsu.h.lhls.hhl.h.h.l.hhss...................hhhh.h.hh.h...h.l....s......h...luhh.E.hh...p..h.h.....t.h.p.t...h...p.h........h..hhh........................................................h..hh....h..h...h..h.....h...h....h.....h.............h...h.....................h........h...........h.....h.........h.....h......h.......h.....h....h....h..h.....h.h...h.lhhhh..........................................................t..ht.p..h..h...h...s..l..h...s..h..h..h.h.shhh.....................................................................................hh.h.h..t...s...h.........t....G..h......h...h....l.....l..h..h...h...h.l.lh..s....sDsuAYh.....h.....G.....+.....h......a.....G......+......+....Kl..............hP........p.........l.......S....Ps.K...ThEGhlGG.ll..s.uh...ll..u..h..h..h..s.h.h..hs...............................................................................................................................................................................................hs.hht...h.l.l.h..u.ll..h.u.l...h.u...hGDLh.EShhKRphG...l.K.........DS...G...p...llP.G.HG.....G....lLDRhDS..h........hhssPlhhhhh...h...............................................................................	1	615	1145	1531
+174	PF04145	Ctr		Ctr copper transporter family	Bateman A	anon	Pfam-B_3006 (release 7.3)	Family	The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane.  A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.	22.10	22.10	22.20	22.20	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.75	0.71	-4.14	116	1128	2009-01-15 18:05:59	2003-04-07 12:59:11	10	21	303	3	804	1068	7	123.20	22	63.53	CHANGED	MsMh....Fphsh.ssslLFpsWpss..otutahsohlhlhlluhhhchLchhppphcpthh......tp........thtt......t...............................................................................thphhtclhp.....uhLah......lphsluYh..LM.....LlsMoaNshlhlulllGh....slGhhhF	...................................................................................h.Mh.....F.hsh.p....hsl..laptWphp...............o..s..thhhuhlslhhluhhhEhLphhpt.ht..t.t.hh........tt.........................................................................................................................................................................................................................................................h..h.chhp.....shlah......lphsluYh..lM........LhhMoaNshlhlullhGhhlGhhh...................................................................................................................	1	242	446	686
+175	PF00394	Cu-oxidase		Multicopper oxidase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Many of the proteins in this family contain multiple similar  copies of this plastocyanin-like domain.	20.30	19.90	20.30	19.90	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.94	0.71	-4.33	72	9871	2012-10-02 17:41:00	2003-04-07 12:59:11	17	57	2516	325	2092	9906	260	140.70	23	37.09	CHANGED	cphslhluDWY.cpsspsh...h.ts............s..sDuhlINGpst...s....................................hhslsVpsGKpYRlRll.ssuspsshsFpIsuH.phollEs......DGsasp..Phss-slpIhsGQpaulllsA...sp.s...sssYaltst........h..s....htsssssulLcYpsu	........................................................................................................................t..hhlh.pDaa...pstps....h.p...h.t..tt.s...th...............................thhssp..h.lh..N.G.............................................................................................................................sss...h.s.s.p...sh..p...s..t.h.s...............p.l.h...ll..s..t.u...s.p...c.s....h....s......a.....hI..........s.........G........H..............h.l..ltu..........c.....G....p.a.ss..............s.h..s...l....-.....s.....h..h........l.t.s.G.............pthssl...hsh......pp............ss.Y....hhhs..........................................s....................................................	0	504	1249	1757
+176	PF03712	Cu2_monoox_C		Copper type II ascorbate-dependent monooxygenase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.	20.50	20.50	20.60	20.90	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.01	0.71	-4.88	25	590	2009-01-15 18:05:59	2003-04-07 12:59:11	10	37	157	18	376	631	214	149.50	26	25.41	CHANGED	pa.AGlhhLhsshh....sIPPspssash-ssC.hpp.scshaP......FAhpsHsHthG+hlsuhphRssp.....hphlu+psshsP..QtFYslc..phlcVpsGDtLsscCoY-op..sp.........spssthGtospDEMCshYlhYYs.....-ssphpshtsChustssp...hhpshssts	...............................................AGhh.hsh........hIPPsppsh...p.shCphpp..sp.hhs...............FAhhhH.....sHhhG+..tlps..h.phR.ssp.......................phphlscss.......sas......thQt...h.h.....lp.......p.lsl.hs...........GDhL.....hscCsasop....s+.............................spsThhGh..ssp-EMChhalhY.Ys......t...p.h..h....t..t................h....................................	0	189	216	300
+177	PF01082	Cu2_monooxygen		Copper type II ascorbate-dependent monooxygenase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.	21.10	21.10	21.60	21.50	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.20	0.71	-4.20	38	534	2009-01-15 18:05:59	2003-04-07 12:59:11	15	24	136	18	344	574	28	124.70	27	21.58	CHANGED	spph-lthpsl..hPsp.sssYaCphh+lss....p+aaIlpaEPlhst......shlHHMlLatCs......pshsp..................sstC.....h.tphthC.......spllhAWAhGutshta.PccVGhslGtst.s.s+allLEVHYss..sshpsups	.............................h...h-lhh.sl...hPpp..pssYhChhh...cls......pcpal..l.p.a.-Phhs................shVHHhll......at...Cs........psh.sph......................st.C...........hs.tph.t..sC................ppll..hAWAh.Gut....s..hph..Pc..csGhslGsss...sspYlhLplHYss..sth....th..........................	0	156	180	269
+178	PF02845	CUE		CUE domain	SMART	anon	Alignment kindly provided by SMART	Family	CUE domains have been shown to bind ubiquitin [3-4]. It has been suggested that CUE domains are related to Pfam:PF00627 [4] and this has been confirmed by the structure of the domain [5]. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2 [2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-7.57	0.72	-4.44	132	1581	2012-10-01 23:03:33	2003-04-07 12:59:11	11	43	284	10	1034	1491	4	41.20	24	8.01	CHANGED	ppstl..pplpphFPslspphIptsL.ppsssl-tslstlLphs	............thl..pplpphFPs.lspphlppsLt..tpsssl-tslspLLph..........	1	287	499	788
+179	PF00190	Cupin_1	Seedstore_11s;Cupin; 	Cupin	Griffiths-Jones SR	anon	Prosite	Domain	This family represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins.  Plant seed storage proteins provide the major nitrogen source for the developing plant.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.78	0.71	-4.76	225	3563	2012-10-10 13:59:34	2003-04-07 12:59:11	17	24	631	221	1395	6143	837	141.10	18	62.47	CHANGED	hshtpssp....hhpspuGtl...pthsspphs.hhtphthsththth.pssulhsP+ap..sAspllaVhcGpuhhshlssss...........................................................................................p.hppc......lppGDlhslPtGhshhhhsst..psshthsshssssss...................lst.hhtpsFhlusppsp	........................................................................................................p.t.su..h...p...h.s.s..pphs........tth..t..h..s..tsth....h.tss.u.h.h.....P...Hap..pA..s....c..lhal...l...p.G.......p..uhlsh.l.ssss......................................................................................................................................ph.hspp......lptGD..lhh......hPt..G...h..s..a.a.h.h...s.......s........t......s....s...sh..t.l..h.h...h..p...sss..t...................................hs..hh.psa.hs..................................................................................................	0	198	814	1141
+180	PF04889	Cwf_Cwc_15		Cwf15/Cwc15 cell cycle control protein	Mifsud W	anon	Pfam-B_6589 (release 7.6)	Family	This family represents Cwf15/Cwc15 (from Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively) and their homologues. The function of these proteins is unknown, but they form part of the spliceosome and are thus thought to be involved in mRNA splicing [1]. 	27.20	27.20	28.10	27.50	27.00	27.10	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.91	0.70	-4.66	30	382	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	282	0	279	376	9	193.80	37	96.06	CHANGED	MTTAHR....PTac.PA+GtpspuG......otpasSRsLPuHTpLK...........hRps.GQssp-ch.......t...p+DLRsEL.ctEtpptscc..........................thhth-stspppshch....spcp.cc..h.........................K+.h.............tpspshDADc........tp.............ssssD--.................uD...........s--DEsttLhtELE+IK+ERtEcct+c-cEtttpctcp+cpclhpGNPLLN.................ttssFslKRRWDDDVVFKNpA+s..cpt+c.pFlNDslRS-FHKKFhsKYl+	...................................................MTTAtRPTacsAp.Gtpst..tt........otthpsR.LP.uH...........TplK..................hRps..sQ.s.....s.t-h.................p..t+-h+tEL.ptEttthtpp...................................................ttt.t......t.t.................................................................................................st..shDuDs.s..............................................tppp-p-................tc.........psc-D-s.ttLh..tELp+IK+ERtpcpt+cEtcpttp-tc.+.tplhpGNPL.LN.........................tsh..plKR..RWDDDV.V..F......K...NpA....+u....cptc......c....FlNDhlRS-FH++FhpKYl+.......................................	0	99	157	228
+181	PF04677	CwfJ_C_1	CwfJ_N_1; 	Protein similar to CwfJ C-terminus 1	Kerrison ND	anon	DOMO:DM04663;	Family	This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909).  CwfJ is part of the Cdc5p complex involved in mRNA splicing [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.63	0.71	-4.46	8	549	2012-10-01 23:45:21	2003-04-07 12:59:11	10	23	278	0	412	1265	265	125.80	29	20.81	CHANGED	spcp++hpps.csChFClsssslccHLlVSlGppsYluLPc.ssL...........spsHslIlPlpHhsss.hols-....-lh-EIppF+KuLstM.asupspDslFaEhs...spRs.HhplpsIPlPpphuch..ushhFp	..................................h...pp.ttt.spChaC....h...s....s.....s.....p.....h.....t....p...H....l...ll.o.l.Gsc.............sY.L.s..lsp..ssL....................ssG..HslIlPlpH.hssh.......sphsc................-sh.c......E....l....p......p....a.....+....p....u....L....p.c..M.....a..p....s.......p....s....p...s.......s.......l.....h..a...Eps..............t+.p......hHhthps.....lP..lPtphsphh...a............................................................	0	144	225	337
+182	PF04676	CwfJ_C_2	CwfJ_N_2; 	Protein similar to CwfJ C-terminus 2	Kerrison ND	anon	DOMO:DM04663;	Family	This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ (Swiss:Q09909).  CwfJ is part of the Cdc5p complex involved in mRNA splicing [1].	21.30	21.30	21.50	21.30	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.14	0.72	-3.50	48	528	2009-01-15 18:05:59	2003-04-07 12:59:11	9	19	269	0	399	536	6	99.10	26	16.57	CHANGED	castpt.hchtshpt...........hp..hspshsYFhVpls......................hsp..shhphl-.....................cpp..cFslp..FuRcVlus..lLsL.pRhpW+c..stpsppcEctcstpF+ptacsF.DaT	................................................h.ph.t.........pshcp..hs.pshsYFtVphs.............................hss....shs.Hhlc..............................................cpt..c.FPhp..FGR..-Vluu..hLs.lt.s....+...tW+p.....sppstc-cppcstpF+ct..ac.aDaT..........................	0	140	219	326
+183	PF01705	CX		CX module	Hutter H, Bateman A	anon	Hutter H	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 6 conserved cysteines that probably form three disulphide bridges.	25.00	25.00	25.80	26.40	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.31	0.72	-4.00	14	114	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	8	0	108	106	0	59.90	32	25.21	CHANGED	YYWsspa....lpsscpP.shCEYpIs-..-DtELpNVsFsNGo+PpSlhFuCsst.ppCCGh-CCssh	....................YYWttta.......hts.pts..hCpa.lsp..pDhp..lpslpFssGop...P.pslhFuCtts.ppCCGhcCCt.......	0	30	40	108
+184	PF04673	Cyclase_polyket	cyclase_polyket; 	Polyketide synthesis cyclase	Mifsud W	anon	Pfam-B_5596 (release 7.5)	Family	This family represents a number of cyclases involved in polyketide synthesis in a number of actinobacterial species.	23.70	23.70	25.00	53.00	23.30	23.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.28	0.72	-3.95	23	122	2009-09-11 03:24:20	2003-04-07 12:59:11	7	2	90	1	40	120	0	96.20	46	87.19	CHANGED	MsPususcVAclFuEpD...sTELP+lhGspRRpLFpa+s.LYFHLh-.ssscssssltpA+sHPpFhclSccLpsalssYDP.sTWRuPpD.AMAppFYpWsA	.....MsPususcVAclFA-SD...uoELP+hhGVpRRpLFpacs.LYhHLlE..s....c....csssttltps..+.s..cP...cFhclSccLpsalssYDP.tTWRuPpD.AMAppFYpWp...	0	10	30	38
+185	PF00134	Cyclin_N	cyclin; 	Cyclin, N-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.54	0.71	-4.57	127	6213	2012-10-03 00:42:12	2003-04-07 12:59:11	18	86	547	190	3707	6602	83	123.90	20	31.34	CHANGED	-IapahpphEtp...t.s.saht.pp.....ls..pMRsILlDWLlc.VppcacLh.ETLaLslshlDRFLutp......l.+pcLQLlGlsuhhlAuK........aEEh...............hsPplp-ashlo.....Ds.sas...............pcpllpMEphlLpsLpapls	......................................................................................................................hp....th.Rt.h.h...h...p..a....l............h..........p........l..t....p.p....h...p...........l........t..t...p..T.h..h.h...u.l......s.....h.h.......-.......R...F......htpt..s.....................lpp...p....p......h.......p...L....l....u......s..ssl.h..........l.....Au...K.............................h..E..Eh...................................................s.s..p.l..p.c.h..h.....h.hs.........cp..shs.................................................tpp..lhphEh.hlLpt.Lpapl.......................................................................................	0	1218	1928	2867
+186	PF02276	CytoC_RC		Photosynthetic reaction centre cytochrome C subunit	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_5109 (release 5.2)	Family	Photosynthesis in purple bacteria is dependent on light-induced electron transfer in the reaction centre (RC), coupled to the uptake  of protons from the cytoplasm. The RC contains a cytochrome molecule which re-reduces the oxidised electron donor.	22.40	22.40	22.50	26.80	20.30	22.30	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.26	0.70	-5.32	25	104	2012-10-01 23:37:15	2003-04-07 12:59:11	13	3	88	20	28	104	73	250.30	32	79.94	CHANGED	h.ppP.ss-shQoG.RGsGMptsp.scslsp.sss..shss.stsssss..usPpAu-lYpNVp.VLGDLosupFsRLMsAhTpWVu.Pc-GCsYCHss.p..sausDshYTKhVuRpMlpMTQplNssWss.HV...upsGVTCYTCHRGpPVPstlWap..ssshssuhtGhsssQNtuss..............ss.saoSLPsDshp.aL....L-.....scsI......+Vpshsuhs...ssssc...s.lppAEhTYuLMhHhSsSLGVNCTaCHNoRAFa-W.sQuTPQRssAahGIcMVR-lNssYltPL.pshhPspRLGPh.GDssKlsCtTCHpGshpPLtGsshlcDaPELAss	.......................................P.....s.QhG.RGhuh......t...t......t..s.s...s....stshAsp.hapNVp.VL.tcls.spFs+lMsuhopWlu...pps..CsYCHs....t.......shAsDshapKhVuRpMlpMTpplNs...pW.....ps..Hs.......stsG....V...oCYTCHRGpshPt.hW...hp.......tt.h....t..ps..t.................s.thsuLP.Dshp.aL.....t......tt.l......pl.s........puhs.....t..tt...s.hppsEhoauLM..ahSsuLGVsCsaCHNopsFhsh.p..p..ssPp+shuhhulpMsp-lNtpah.sh.t..hPt..phh......G...s-s.+hsChTCHpGh.pPL.G..h.phhtpa..L..s...................................	0	14	24	25
+187	PF05038	Cytochrom_B558a	cytochr_b558a; 	Cytochrome Cytochrome b558 alpha-subunit	Moxon SJ	anon	Pfam-B_5327 (release 7.7)	Family	Cytochrome b-245 light chain (p22-phox) is one of the key electron transfer elements of the NADPH oxidase in phagocytes [1].	25.00	25.00	26.50	25.80	21.30	23.30	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.15	0.71	-4.66	4	85	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	62	1	43	84	0	159.20	60	95.33	CHANGED	GpIEWAMWANEQALAoGLILlsGGIVusAGpFppW.FGAYuIAAGVLVCLLEYPRGKRsKG.oThERsGQ+hLTtsVKshGPLoRNYYlRAhLHLulsVPuGFlLATILGssCLsIASlIYLhAAl+GEpWpPI.s+.c-.Rs.VGtoIKpPPoNPPPRPPsEhR+KsuE-.sssA.........NPhsVTspsV	............GpIEWAMWANEQALAuGl.lLlsGGIVu.......sAG.pFptW.F....uA...YuI..sAGVhVCLLEYPRG.KRpKG.oTMERsGQ+YhTslVKhFGPLT...RNYYlRAhLHhh.LuVPuGFLLATILGTsCLuIAShIYLLAAlRGEpWp.PIE......s.+scp..RsplGsoIKpPPoNPPPRPPs-sR+K.s-t.t.ss...........NPhsVp....................................	0	14	17	26
+188	PF01820	Dala_Dala_lig_N	Dala_Dala_ligas; 	D-ala D-ala ligase N-terminus	Bateman A, Moxon SJ	anon	PSI-BLAST 2dln	Family	This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding [2]. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF) [3].	21.60	21.60	23.00	21.60	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.29	0.71	-3.78	176	7730	2009-01-15 18:05:59	2003-04-07 12:59:11	16	22	4347	83	1553	5359	3003	82.10	29	32.44	CHANGED	h+..lullhGGpSsE+-VSltSApslhpuL....p.p..ppaclh.......l.hls.cpG.tahhhtt..t.ht..t......................................................htphDllFslLHGs..hGEDGslQGlL-hhslPYsGs	............................................................plsllhGGhSsE+plSl.Sutslhtsl..................p......tth.p.sh...............h...h.....p....t................................................................................................................................................thsh...ha.hlHG....GE..DGslQGhhchhtlPasGs........................................	0	540	1043	1317
+189	PF01113	DapB_N	DapB; 	Dihydrodipicolinate reductase, N-terminus	Finn RD, Bateman A, Studholme, DJ	anon	Prosite	Domain	Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated  cyclic imine, dihydro-dipicolinate.  This reaction is the  second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both  protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.49	0.71	-4.20	99	5206	2012-10-10 17:06:42	2003-04-07 12:59:11	15	17	4187	43	1251	5533	3347	112.90	28	41.03	CHANGED	l+lslsGAsGRMGppllcslpp.p......sshpLsuul-css......t.shs...........t.....sl.l...sclppshsp..sD..........VllDFT.pPpushpplchshpt.shshVlGTTGa...opcphpplpp.hu...cc..lsllhusNa	........................................h+lslhG.stG+MG....p....t.l.l.p..slt.p...t........p.s..h.p.L..s..u..s..l-pss...............................................................t.ht......h...s...l.....l............ss..l..s...s.l.hsp.........sD.......................................V.ll.......D.F.......T.....p..P..p...s....s........h.....p..p...l..p...h....s...h...pp...s..........h.....s......h.V..l......G...T.T.G.h........sptt..h..t...t.lpp...hu...pp..........hsh.lhusNh...........................................................................................	0	372	808	1057
+190	PF01682	DB		DB module	Hutter H, Bateman A	anon	[1]	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 12 conserved cysteines that probably form six disulphide bridges. This domain is found associated with ig Pfam:PF00047 and fn3 Pfam:PF00041 domains, as well as in some lipases Pfam:PF00657.	25.00	25.00	28.80	25.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.97	0.72	-11.48	0.72	-3.96	26	351	2009-01-15 18:05:59	2003-04-07 12:59:11	14	38	33	0	314	315	0	96.30	27	28.50	CHANGED	CCpspt.lsstChp.hCsapsh......h.shhhtsspCsh..phsplhpCAupscDHosCCtcpuVs.......spChshCp.p.s......hsshthshhsChp.phsshhpCFh	..................................CCppps..l.sstChs.hC..sapth.......................p.h.hhtsspCsh..phsphhpCAup..G..+.............D..HopCCt..cpGls.....................spChshCpsp.s......hsslthshhsChp.thpshhpCa............................................	0	111	144	302
+191	PF05011	DBR1		Lariat debranching enzyme, C-terminal domain	Wood V, Bateman A	anon	Pfam-B_9676 (release 7.6)	Domain	This presumed domain is found at the C-terminus of lariat debranching enzyme. This domain is always found in association with Pfam:PF00149.	21.10	21.10	22.50	21.40	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.26	0.71	-4.31	24	333	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	279	0	244	330	6	132.20	28	26.79	CHANGED	lPc....os+s..T+FLALDKCLPtRcFLQll-lsstsss............hpLpYD.EWLAIh+shsphhp......l.sshss.sstspG....c.tacshhE-ppphVpEcl.ttscLpl.PcNFshTAPsacsu..sth...sst.PstatNPQTspFCcLLGlcshh	.....................................h......tsps...T+FLALDKCLPc....R...c....F.....LQl..l-ltstssss............................................pLpYD.EW...L.....uIh+shpshhs..............................l.t.p.........stp.t..................hts.....p.pthp.l..pp...l...........t...t..p......htl....P.p....sF.....T.ss.s.ass....s...............................hhNPQTttasthlsl....h.......................................................	0	86	135	205
+192	PF03107	C1_2	DC1;	C1 domain	Bateman A	anon	Pfam-B_16 (release 6.5)	Domain	This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in Pfam:PF00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions.  The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.83	0.72	-3.83	90	558	2012-10-02 13:15:50	2003-04-07 12:59:11	11	57	24	0	370	664	0	31.30	34	11.07	CHANGED	hhCslC.c+phssh......hYpC.ppss........aslHsp.Cu	..........CslC.ccp..lssp.....hhYpC..pcCs........aslHsp.Cs.	0	312	351	358
+193	PF00383	dCMP_cyt_deam_1	dCMP_cyt_deam;	Cytidine and deoxycytidylate deaminase zinc-binding region	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.79	0.72	-4.37	59	17292	2012-10-02 00:10:39	2003-04-07 12:59:11	17	96	5079	154	4759	12505	5590	105.20	26	47.17	CHANGED	hp.cchhhphAhthAppuh..stsphsVGAllVp..sspllupGhNtp.tuts......................................................shHAEhsAltpAsp....t.ph........................s..sslal.............ThpPCs.h......Csphllpt.u.lp+Vlhst	..................................................................................................................................................p.hhphAlp.h.Appuh.......st.sphsV.G.A.ll..V...........p....................s........s........p..........l...........l..........u.........p..G.h.N.t.p.....t.s.ts.............................................................................................................................s.hHAEh.p...Alpp......Aspt....t...t.ph............................................................................................................t.s.....sslYV.......................................T.l...pP..Csh................Cspsll...ps...t..ltclhhh.t............................................................................................................	0	1638	3063	4050
+194	PF05026	DCP2		Dcp2, box A domain	Wood V	anon	Pfam-B_10622 (release 7.6)	Domain	This domain is always found to the amino terminal side of Pfam:PF00293.  This domain is specific to mRNA decapping protein 2 and this region has been termed Box A [2].  Removal of the cap structure is catalysed by the Dcp1-Dcp2 complex [3].	28.00	28.00	29.10	29.90	26.80	27.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.02	0.72	-4.09	23	313	2009-09-11 21:45:37	2003-04-07 12:59:11	8	12	259	7	225	319	2	85.10	41	13.28	CHANGED	cchL-DLssRFIlNlPpE-LsolERlhFQlEEApWFYpDFlR.hsP..tLPshsh+sFupplhp+....CPLl.pa......ttshcpALpcFtpYK	...........clLDDLssRFIlNlPpEE...l....p....sh.........RlhFQlEpAaWFY.DFhp.............t.......t.s......P......sLP.sh.s.l+sFut..t.............l.F....p+......CPh..Ltta......ttchcchhpcappYK...............	0	83	130	190
+195	PF03607	DCX		Doublecortin	Griffiths-Jones SR	anon	PROSITE	Family	\N	21.40	21.40	22.10	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.58	0.72	-4.38	53	1063	2009-01-15 18:05:59	2003-04-07 12:59:11	12	41	119	7	602	931	2	60.20	32	14.44	CHANGED	lllsp.+phpoa-slLsclTc....plpLs.tG.VRplaThcG.+plsslcc.LpsGpsYVsu.upE.tFK	......................hhlsp.+ph+oF-slLs-lTc.......tlp..L.....s...pG..V+plY.Th-G.+p.....l..ssLp-..l...t..-...u.ps..aVss.u..E..F+...........	0	142	196	349
+196	PF03455	dDENN		dDENN domain	Callebaut I	anon	Callebaut I	Domain	This region is always found associated with Pfam:PF02141. It is predicted to form a globular domain [1]. This domain is predicted to be completely alpha helical. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family [1].	21.10	21.10	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.47	0.72	-3.90	46	1393	2009-01-15 18:05:59	2003-04-07 12:59:11	14	84	197	2	782	1322	6	70.50	27	5.94	CHANGED	lsp.plpcsFLphhsp..lhtsYcsalph.p..tt...............tFpppuFlcs.pspshp.....pFlpphhco...QhFspFIcc+	...........................sttlptsFl+hhsp...lht..s......Y....c.palphhp...tt.p............................................sF.pp....p.uFLps...psps.p.......pFl.pphh.cT...QhFttFIpp+............................................	0	198	284	494
+197	PF02791	DDT		DDT domain	Iyer LM, Aravind L, Bateman A	anon	[1]	Family	The DDT domain is named after (DNA binding homeobox and Different  Transcription factors) and is approximately 60 residues in length  [1]. Along with the WHIM motifs, it comprises an entirely alpha  helical module found in diverse eukaryotic chromatin proteins [2].  Based on the structure of Ioc3, this module is inferred to  interact with nucleosomal linker DNA and the SLIDE domain of ISWI  proteins [2][3]. The resulting complex forms a protein ruler that  measures out the spacing between two adjacent nucleosomes [2].  In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket [2].	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.84	0.72	-4.20	42	658	2012-10-07 04:36:59	2003-04-07 12:59:11	12	81	241	0	419	641	5	61.50	26	4.04	CHANGED	sp.shschL......tlacFLpsFuclLpLssF.....oh--FtpAltspssp....LhsElHhsLl+h..llps.ps	............s.pthuchL................hlacFLpsFuclLtLs.sh...................ol.-.s.h.ppAL.......h.spssp......................hhsElphsLL+h..lhpt.t.....................	2	113	213	327
+198	PF00270	DEAD		DEAD/DEAH box helicase	Bateman A, Bruskiewich R, Sonnhammer ELL	anon	Published_alignment	Domain	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null --hand HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.48	0.71	-4.76	182	63415	2012-10-05 12:31:07	2003-04-07 12:59:11	24	708	5596	153	23464	73599	16995	166.80	22	21.58	CHANGED	osl.Q...tpsls...hlh..p.s............cD.ll........stutTGoGKThsahl...shl...ptlht............................................................................................................t................................................................................................................pslllsPT+pLspQhhpph...pphhph..............h.l...........psshl...hG........shs..hp.pptthl.........ps.scllluTPsc.....lhshlpp....th.th........hp.lph..lVlDEscphhs.........sats....plpp......lhpt..h....................t.................hp.hlhhSAThs.pslpcl	............................................................................................................................................................................................................................................................Q...tp..s.l.........hh......p..s...............................ps....h..l.....................st.u...t..T...........G...o....GK............T.....h.....s...h..h..l........s.h..l........p..t..l.....pt...t...........................................................................................................................................................................................................................................................................................................................................................................psl..l...l...s...P...s...+.....t....L.......A...t....Q..........h.......h.......p...p....h...........p.p..h.h.tt................................t.h.......................................................ps.s..hl................hG...................................s.hs.........hp.......p..p...hphl...............................pt.t....s...c..l.........l....l..u.....T.s..ut.............................l..h..s...h...lpp...............h...th..................................pp.....l....p....h.........l.........l.l..D.E...s..c..c...h.h.s..................................sh.t..................................p.l.p.p..........................lh.ph.....h.....................................p........................................hp..hlhh..S.A.Ths..tt....h...................................................................................................................................................................................................................................................................................................................	0	8187	14068	19550
+199	PF00531	Death	death; 	Death domain	Bateman A, Griffiths-Jones SR	anon	Reference [1] and [2].	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.70	0.72	-4.21	88	3125	2012-10-01 21:41:45	2003-04-07 12:59:11	17	542	171	79	1743	2836	0	80.60	19	10.09	CHANGED	pplhphl..sphhsppWpplu.cpL...slspsplcphcp...ps......ptshplLptWtpp......puolssLhpsLpphstpcssct.lpphh	................................t......h....sp.hspsW...p..pL....A..ppL.......sh.s..ppplp..tlcp.............pp...t....ptshp...lLptWtpp..........t.....t.s......u..........s......l.......s..p..LhpsLpp..hs..ppchsc..lt...t..........................	0	804	885	1205
+200	PF04626	DEC-1_C		Dec-1 protein, C terminal region	Kerrison ND	anon	DOMO:DM04594;	Family	The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1]. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). Alternative splicing generates different carboxyl terminal ends in different protein isoforms, so this is region is the most C terminal region that is present in the main isoforms.	25.00	25.00	88.40	36.70	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.84	0.71	-3.99	2	24	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	11	0	11	30	0	120.90	52	10.72	CHANGED	MPSMMQREVEDEDNKAEDDLVGEAGPQMPENEGTARHKVDALGVGGNKRKKSKSKSAPPTVINYYYAAPQRPVVQSYGTSYGGGGYGSNAYGVPRPVNSYQSQGYRAAVGNDEVDEMLRQHQTMARTINPKQ	....................t.....Qpt.p.tppsct.p..-sll.GEAtPQMPEstGpARHK.VDhLGlGGs+..RKKSK....upou.PsVINYYauuP....p.............h...........h.....s.............SYGTSYG...GGGYGS...NAYGs..........h.s...NsYQ...t......GYR.AAVGNDElDpMLRQHQTMAps......p...............	0	3	3	8
+201	PF02141	DENN		DENN (AEX-3) domain	Mian N, Bateman A	anon	IPR001194	Family	DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways [1].	23.40	23.40	23.40	23.40	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.14	0.71	-4.57	40	1791	2012-10-02 14:18:06	2003-04-07 12:59:11	16	97	243	2	1055	1806	19	178.90	27	16.35	CHANGED	hsPcshCllS+hsahssF.cchLstlhphhtpus..............hslcsaltshltpsshPsPGpshph.p...husp-hhhhspPt.sspL..Ph..pssshp.....tLapsLuscNllpLasssLh.Ep+IlhhSpchshLopsscAlsuLLaPhpWQasYIPlLPspLl-sL.sAPsPFllGlpuphhs.....hhps.s-lllV..DLDss	......................................................................................................................................h...pshsl.lS.p.hshhpha.p..........c...hLt...lhphhh.ps.......................................................l.p.t...h..l..tp......l..hph.s...h..P.s.s....u..ps.hhh...........................ts.t.thh..h..h....pt..P......sspL.......sh.......pshsh.p.........................l...h..p.tL.u..l..c..sl..l..p........lh.....sshLh..Ec+l..lhhSp.ch.................s..h......Lo....t.ssc...u........l..su..ll..........a..P..hp....W...p....a...s..a...IP...lL..P..s...p.....h.....h...c.........h.l....s...............u..PsP.........al.lGlp.u..p..hhp.....................t-l..l.hl..DlDs.............................................	0	352	490	745
+202	PF00610	DEP		Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Ponting C, Schultz J, Bork P, Martemyanov K, Thorner J	anon	SMART	Domain	The DEP domain [1] is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell [2-3]. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting [4-5]. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit [6-7].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.43	0.72	-4.23	133	2616	2009-01-15 18:05:59	2003-04-07 12:59:11	16	134	308	16	1545	2411	15	72.20	25	9.41	CHANGED	ulplpcc+h..thps..atpsFsGs-hVcWLh........h..pt.htsRpcAlpluptLl..............ppGhlpplpscp.t..............Ft-s.thhYpF	.......................lps+ch...hh..ps..h..psF...s.....G.s...-lV-WLh......................p.h.....p....hps.RpcAlpluptL.l....................................................cpG..hlpp.lssct.p...........................Fp-s.thhYpF.....................................	0	410	638	1072
+203	PF02272	DHHA1		DHHA1 domain	Bateman A	anon	Bateman A	Family	This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members [1]. This domains is also found in alanyl tRNA synthetase e.g. Swiss:P00957, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.	21.20	16.00	21.20	16.90	21.10	15.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.45	0.72	-4.27	133	12856	2009-01-15 18:05:59	2003-04-07 12:59:11	14	38	4786	16	3060	9901	3277	66.90	22	10.25	CHANGED	ppsllhhs......pssphpsssRs.pslshp.......pllpphtt.hsh...tGGG+spsAuushppsp...........lpphlptlpp	...................................t...hllhs.........ttss....p...l...p...hssR....S..h.ps..lshp...........pllc.ph..t........h.h.....pGGGHsts..A..us.s.hpsss.............lpphhpth..t...........................	0	1073	2042	2615
+204	PF04922	DIE2_ALG10		DIE2/ALG10 family	Wood V, Bateman A	anon	Pfam-B_9570 (release 7.6)	Family	The ALG10 protein from Saccharomyces cerevisiae encodes the alpha-1,2 glucosyltransferase of the endoplasmic reticulum. This protein has been characterised in rat as potassium channel regulator 1 [2].	19.70	19.70	29.00	23.10	18.30	18.20	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.52	0.70	-5.44	5	365	2012-10-03 03:08:05	2003-04-07 12:59:11	7	9	246	0	265	367	4	294.00	27	77.66	CHANGED	s+hVPEPYMDEIFHlsQAQpYCcGcao..pWDPhITTPPGLYllSlu...sLpPu..hhusSsloh........LRhlNhLsuV..hhhshLlhRhIplhN.t.u..slsahAloLusaPlLaFFoFLYYTDluSlhhVLhuh...LshsaGsh+s...SAFhuslSshF....RQTNIIWsuFlAso.hhs.phu.tp.pllQcphs-...........LRohlpaLK.........hFl+.....SlccFSsLlL.....................PYhhlhluFhlFllWN.GuIVLGDKSuHpAuLHluQIFYFhsFsAhFSaPhaISsNhl+Hh++p..lp+phsppShlllulVhLlsaF.ThVHPFLLADNRHYTFYlWRRllsp..+hlh+ahLsP.......uYlauh....ashtslosp...........hs+loWpLLahlsTlloLVPuPLlEFRYYILPYllWRL	.............................................................s.......ah....DEhFHl.Qs.tYhp........t.....pa.............WDshITT.PGL....Yh.h.uhh............h.sh..h......t..h..s.....................................LR.hs..h..hh..h.......h..h..hh.h.....p.......h............................h...t........................................................................................h..........s....h....s..l.....hhP.haha.hLaYTDhhShhh....ll..h...................h....h...........t.....h.....................s.s.......h....h...u.hh.......uhhh........RQTNlhWhh....h.h.hs................................h..........................................................................................................................................................h...........................................sah.h.hhhFhhFlh.hN.tulsl..................Gc+ptH.s.s..hHhsQhhYh...hhh.h.h...s.h....s...h............h...........................................h......h..............................h.........................................................h........h........h............h....h....h....h........hhh..ohh......H.ahLADNRHYhFYlaphhh............hhthh..hhs.......................hYhhsh...........h..h.h...h......................................................h.......hh..h..h.shhhshhst.LhE.RYahlPhhhh......................................................	2	82	142	217
+205	PF01843	DIL		DIL domain	Bateman A	anon	[1]	Family	The DIL domain has no known function.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.40	0.72	-4.15	56	1158	2009-09-11 05:00:57	2003-04-07 12:59:11	14	77	276	3	698	1062	2	99.80	30	7.74	CHANGED	plhsQLapaIss.hhNsLlhR+sh...soappGhpl+.hslspl-cWscstshpts...shppLcplhQAspLLpl.pKpphp.-hchltphCs...sLsstQlh+llstYpssshp	.................................QlhsQlFhhlss.hhN..........s.Llh..R+ch..................soasp.Ghpl+.hsls.pLE.cWhcs...ps.......ht.u.................uhppLp............l.hQAspLLph..p.....K..tp.p...shphlpshC...........................tLost.Qlh+lls.Ytssp..t.......................................................	0	167	330	521
+206	PF03018	Dirigent	disease_resp; 	Dirigent-like protein	Griffiths-Jones SR	anon	Pfam-B_835 (release 6.4)	Family	This family contains a number of proteins which are induced during disease response in plants. Members of this family are involved in lignification.	27.60	27.60	28.30	28.30	25.30	27.40	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.86	0.71	-4.68	86	847	2009-09-13 07:42:01	2003-04-07 12:59:11	9	14	70	0	466	810	1	136.60	29	66.27	CHANGED	phscl+hYh.HDhls......G.sssTu.stVssssssst.................tFGslsVhDDsLTcGsshs..Sp.h....VGRAQGhYlhsupp.sh.....shhhuhohVFss..Gcas....GSTlslhGts.h.hsps..REhslVGGTGpFRhARGashh+Th.............phpssssllchs.lplh..h	..........................................................................................phphYhH-hht...........u.sssos.s.lstsstss..............................hFGs.l.sVhDDsLTpGss.hs........Sp..h........VGRAQGhYhhs.u...ts...sh....shhhshs.hsFp....s...s..cap............G...STlslhGt.s.......h..hsps....+Eh.ulVGGT..GpFphA+Ga...shhpoh.............t.tsssshhchslhl.........................	0	35	260	373
+207	PF02377	Dishevelled		Dishevelled specific domain	Mian N, Bateman A	anon	Pfam-B_1381 (release 5.2)	Family	This domain is specific to the signaling protein dishevelled. The domain is found adjacent to the PDZ domain Pfam:PF00595, often in conjunction with DEP (Pfam:PF00610) and DIX (Pfam:PF00778).	19.70	19.70	19.70	19.70	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.64	0.72	-3.77	4	215	2009-01-15 18:05:59	2003-04-07 12:59:11	10	14	74	0	107	198	0	70.60	48	10.92	CHANGED	pR-RsRRRsp.EpAshhpGpsh.GcpcRcsus.h-SSSTlLSSELEooShhDS-EDDohSRhSSSTEQSSuSRL	.....................pRERsRRRpp.....E.cs...s....+.h...NGps..t...u.c.p..c..R...c.hu.u....h-SSSTlMSSELESTSFhDSDEDD.o..h.S...RhS......SSTEQSSuSRL.....................	0	17	27	58
+208	PF02916	DNA_PPF		DNA polymerase processivity factor	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	25.10	26.10	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.20	0.72	-4.00	11	530	2012-10-02 11:47:48	2003-04-07 12:59:11	10	9	359	26	20	382	453	114.60	54	23.78	CHANGED	hKhpKhThslLh.huhlsusshhuhtphl..hs+hsssosYSE..hshSsllstDssIpDlsplpSlluPsssDs-.....lstlpp.stslplssspos.sa.sA.pShlsucs+ulVh	..............KKAcKFTlhLLVhSlLVSSVoLFAlQQFVsLTNRLNuTSNYSE..Yol..SVsVhADS-IcNVoQL..o..S..Vs..APTus.DsENI.pcLLuDIK.o.opssDLTVs...p.So.SYLAAYKSLIuGE.oKAIVL...........................................	0	2	4	14
+209	PF01965	DJ-1_PfpI	ThiJ; 	DJ-1/PfpI family	Bateman A, Enright A, Ouzounis C	anon	Enright A	Family	The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. This N-terminal region of the full-length AdpA proteins is necessary for dimerisation of the molecule.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.94	0.71	-4.74	39	9251	2012-10-03 00:28:14	2003-04-07 12:59:11	19	42	4024	121	2389	11671	1005	150.20	21	67.66	CHANGED	plsslusppst......hpsp.s...........hplpsDtslsclsspp........aDslllPGGhssscpLt............ttlhchl+chhpp.uphluAICpuP.hlLhsssllp....................G++hTua.shps........hpttstphh-..t.Vs....hss.............llTutssssshpFshpllctLt	................................................................................t.........................h.t.t.t.................ht.l.t..s..s.t.s.......l..s..c.l.p....s.sc....................aD.ull..l.P....G.....G...h.u...s..s..p....s..Lp.c.....................................ppl.h.p...h....l.....c.p....h....h..........p..........s.....s..........K............lu...A.lCpuP..th....L....s...s.s.....s.l.hp.........................................G.+.p..h.T.u...a..s....s..h.pp..........................th.p.t..h..u..s...p..a...h...c.............t...tss.......................hDt............................................pllTupsPsss.thuhtllp.l............................................................................................	0	717	1413	1949
+210	PF00751	DM	DM-domain; 	DM DNA binding domain	Bateman A	anon	[1]	Family	The DM domain is named after dsx and mab-3 [1]. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains.  The DM domain has a pattern of conserved zinc chelating residues C2H2C4 [2]. The dsx DM domain has been shown to dimerise and bind palindromic DNA [3].	21.70	21.70	22.20	21.70	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.05	0.72	-4.43	26	1027	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	215	1	380	930	0	45.10	62	16.36	CHANGED	RsPpCuRCRNHGl.hs.LKGHK+h.Cpa+sCpCpKCtLlt-RQ+lMAAQ	........R.PpCARCRNHGl...hosLKGHKRa.Cc..........aR-CpCpK.......CpLlsERQRVMAAQ...........	0	112	146	271
+211	PF01068	DNA_ligase_A_M	DNA_ligase; 	ATP dependent DNA ligase domain	Finn RD, Bateman A	anon	Pfam-B_788 (release 3.0)	Domain	This domain belongs to a more diverse superfamily, including Pfam:PF01331 and Pfam:PF01653 [3].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.23	0.71	-4.95	46	3956	2012-10-02 00:43:09	2003-04-07 12:59:11	16	83	2053	23	1751	4137	1269	187.60	23	33.16	CHANGED	PMLAp.hp..shtphhtph...................ttshhsEhKaDGtR..splH..t.pssphphaSRshcshTt........phsclhphlt.pthhssh.p..hlLDGElls..hs.pptphhPFttltp+h.+pph..........t..............phslshalFDlLhh.........sGps.L.......hphslpcR+plLpphh...................psclhlspthpssshc-lpchhcpslppGtEGlllKs...ssuhYcsu..+R.spsWlKlK	.................................................................................................................................stsahhEhKaD..G.hR........s.ht....................h...ps.....s.......p........h........plh.S......R....s....sc.shos..................................th.s.p.l..h...t....hh..........th.....h...........h..........t..t.............p.............hlLD..G..Ells.............h........t..p.........t.....t......h...h.s...F.pt.ltpp.h......ptph...................................................................phtlphhsFDllhh..................................sG.ps...l....................hph...sh...pcR.+...p...h...L..cp..hh......................................s..s..s.p...h...p.h..s....t...t......h...............s......p............s..............p...p.........h..t.......p.........h.......h.....p........p.......s....h.......p.......t...u.......h.......E..GlhhKp..............hsu...Y.....psG.....+R.....tsWhKlK..................................................................................................	1	555	1043	1451
+212	PF04679	DNA_ligase_A_C		ATP dependent DNA ligase C terminal region        	Kerrison ND	anon	DOMO:DM04655;	Family	This region is found in many but not all ATP-dependent DNA ligase enzymes  (EC:6.5.1.1).  It is thought to constitute part of the catalytic core of ATP dependent DNA ligase [1].	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.41	0.72	-3.58	150	2662	2009-01-15 18:05:59	2003-04-07 12:59:11	10	60	1269	10	1353	2742	442	102.70	27	15.67	CHANGED	ppsth....GuLLLusacs...........sp.......LthlG+VGTGFsspphpcLtppLp.slt.....tsps.Ph...........t........sshW.l..........cPpl...VsEVpa.s-hTts..................G.....pLRaPp.ah.tlRpDK	........................................tuhhuuhLlGsacst...........................sp.......................................hhhlu.+s.uoG.ao-ppl.pp.lp..pp.Lp...sht...........hppt.sh...................................t..........tssha..l................................cPph....VhElpa.s.ph.stu...........................G...slRa.Pp.ah...+lRpDK..............................	0	429	801	1111
+213	PF04675	DNA_ligase_A_N		DNA ligase N terminus	Kerrison ND	anon	DOMO:DM04655;	Family	This region is found in many but not all ATP-dependent DNA ligase enzymes (EC:6.5.1.1).  It is thought to be involved in DNA binding and in catalysis. In human DNA ligase I (Swiss:P18858), and in Saccharomyces cerevisiae (Swiss:P04819), this region was necessary for catalysis, and separated from the amino terminus by targeting elements. In vaccinia virus (Swiss:P16272) this region was not essential for catalysis, but deletion decreases the affinity for nicked DNA and decreased the rate of strand joining at a step subsequent to enzyme-adenylate formation [1].	21.40	21.40	21.40	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.99	0.71	-4.46	154	1767	2009-01-15 18:05:59	2003-04-07 12:59:11	9	63	1048	8	992	1785	366	162.80	20	23.21	CHANGED	h.atpls.chhppl....pp.....souRhph.................sphlsshh...cp...h.ttp................lssslalhhspl.hPshp.sp.clGlup.phLh+.slupshs..hs.pplcp......thpp...........................hGDlu.sstphh......pppp.h.h...........psLTlp..c.VhppLpclAphsG..........ps......SppcKhphlppLhsps..ss.................tEt+allRhlhscLRlG.luctslhsAlup	........................................................h.ths.phhptl.........pt..................sstp.th.........................hp.hltphh.....pp...h.t.t........................hh.shhhhht.h.l.hs..........ht..t.................h...hsl.tp.p....h.lhc.hhsp..hhs......hs.....tthct..................phtt..........................................................hG..Dlu.tshtthh..............................pppp..h..................ssLTlp....p.V.ptLpplup...h.st......................................t..........spppph.p.h.......ltpl....hp.ps..ss.......................pEt+all.Rh.l.t.t.............c.l.R..l.G.hupphlhpAlu...........................................	1	319	572	820
+214	PF00875	DNA_photolyase		DNA photolyase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_777 (release 3.0)	Domain	This domain binds a light harvesting cofactor.	24.70	24.70	24.80	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.76	0.71	-4.50	143	3841	2012-10-02 18:00:56	2003-04-07 12:59:11	13	21	2592	52	1233	3283	3027	163.30	23	33.49	CHANGED	slhWFR.cDLRlpDNsALh....tA......hps...s..t.......llsla..lh-sp.........................ussptt..aLhcuLpsLpppL....pphG...spLhlhpG.s.......stphls....pl.sp........phs.sssVahscchpshtpppDpplpptLp.p.........slph..ppapsp.hLhp...Ptpl.......s...psu.psacVFTPFh+thhp....ph.............shss..Pp	.................................lhWFR.cD.LRlpDN.ALt.....................tA............hps.....s..st................................l.ls.la..lhsPp..........t.t.......................................ustphp...alhpsLpsLppsL....tp.h...s..............hs..L...hlhp.u.s.................................shphl.....pl...sp....................................ph.....s.....ss.....pl.....a.hs.tp.h.........p.s...p.p.pR.D..p..t.l..p..p...t..hp..p.................t..s..l.th..pth.p.s.p...hlht...s.tpl...h............s......tps..p.aplFosF.hpthhp.hh.................h.h....................................................................	0	406	772	1048
+215	PF00136	DNA_pol_B		DNA polymerase family B	Sonnhammer ELL	anon	Prosite	Family	This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.64	0.70	-5.71	67	6234	2012-10-02 01:06:00	2003-04-07 12:59:11	16	79	2425	290	1405	5186	2614	299.90	23	42.52	CHANGED	Gpph+lhshLLctstpcshllPspppt......................................................................pptsYpGAhVl-Php.Ghapsslh....llDFuSLYPSIIhsaN.....LCaoTllts......................................................................................................thsphp.p........chhp..hh..t....hhsp..splppulLspLLcphlp......hR+th+pthtpsps.hp............phlhDtpQhAlKlssNSsYGhhGsssu.hL.shslAtolTshGRphlppTpchlcph.........h...................................shcVlYGDTDSlalphss.sh......................ptshphucchsptlsppl........hhpslcLEhEKsaptllLls.KK+YhGlhh..........t..sch.hKGl-hVR+sssphspphhppllchlhpcpsssps.......httlp............hhhchlps.......................htp.h.tttl..slsphlhoptLo..+shssYpspp...........Hlplst+htpcs...........tphPtluDRlsYVllps......................................................tptsh.hchAccsp.ah............l.lDscaYls.plhtslpplhpslhhs.................sshtpsphltthh.pp	.................................................................................................................................................................................................................................................................................h.s.h.V....hp.s.......s.h.....a...t......l......hhDatuLYP.SIh.shp.............l.s.sshh..........................................................................................................................................................................................................................................................................................................................p..h.s...l...l...sth...ltphht.........................................hRpt.h.+...p......h.tt...t..............................hhs...Q....Ah.....KlhhNuh.YGhhG.s.t............t.u.....h.h...s.h...lA.s.slThhG......R.phlppscph.lct....................................................................................................................th.p.lhY..GDTDSh.hl....h.......................................................................t....t..h.t.t.h...ht...p.........................................t......phch-..th....a...........hhh.......................t....K.........K........p...Yh.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.........................................................................................................................................................................	0	474	778	1158
+216	PF03104	DNA_pol_B_exo1	DNA_pol_B_exo;	DNA polymerase family B, exonuclease domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	This domain has 3' to 5' exonuclease activity and adopts a ribonuclease H type fold.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.10	0.70	-5.57	32	3652	2012-10-03 01:22:09	2003-04-07 12:59:11	14	66	1910	166	1392	3971	1871	275.30	17	26.07	CHANGED	hsp-stsshhpshshpsYFYhts.cspp..phtp......................................hhcthpsthhplchlp+.............psh.h.ts......hh+l.hss...h......plpp.h..............sthpha................................EhslshhtRahlDp.slhshsWhplpts............................ht.sphch.h.hpsl.sh.tpt......sthplhuFDIEshtttt....FP..-sppD.lltIShhh.t.s.......................hssshpphhaoltsps...............................sstlh.a..ssEhclLptahphlpphcP-llsuYNhssFDhsYlhsRsptl.......hshthp.htph..tth..............................ppppphphsGtlthDhathhpcch........phsSYpLssV	......................................................................................................................................................................h...........................................................................................................................................................................................................................................................................................................hhtl.hhtt..t.h....................tht..p...ltt.........................................thhp.ha..................................................................................................Es.sl..................+ahh-p....t....lh.....s.......s.W.h..php.t.................................................................................p...h...h.........t...p.h.....s.h...t.................................sshp.h....h.uh..DI.E.s.ttp.t..........................t...p...lh.t..I..u..........................................................httshtp.hh.h.h.l..t.s.p.s............................................................................................................shpl.....h......ssE....hpl.Lp.........thh.........t..hh....t....p...h..........c...P...D....l....l.h..GaN......l..p..FDh.h.lhpR..........s.p...t.h...........................h.t..h.t..........t..........ph.....tt.t..t..h.......................................................p.t..thh.p.htGplhhDhh.p.hhppth.........phtoapLpsl..................................................................................................	0	451	750	1140
+217	PF04081	DNA_pol_delta_4		DNA polymerase delta, subunit 4 	Wood V, Finn RD	anon	Pfam-B_25322 (release 7.3);	Family	\N	25.00	25.00	27.80	27.60	24.50	24.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.68	0.71	-3.85	3	194	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	154	0	132	178	1	116.20	30	71.61	CHANGED	sG+KssI+DVaPVVVRcEusQuHp.K...uEpuP..............h+p-.ELu.tlEEP.......WNQIcuERhuEsl...HsEslTclEhlLRaFDlou+YGPClGITRLQRWpRAKphGLNPP.EVhpVLhL+EGDsEsRh+ESLaH	.....................................................................................................tt.tt.................................................................................................................................................................pt..sthE.clLRpFDls.pYGPClGloRLcRWcRAppLGLs.PP.EVhslL.tcps.c................................	0	38	71	100
+218	PF00772	DnaB		DnaB-like helicase N terminal domain	Bateman A	anon	Pfam-B_1000 (release 2.1)	Domain	The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.18	0.72	-4.15	156	5852	2009-01-15 18:05:59	2003-04-07 12:59:11	16	42	4498	45	1143	3975	2460	101.40	33	21.41	CHANGED	t.Pps...h.-AEpulLGulLh..s..sc..shsplhshL.p...s-cFapttHphIFcshhcLhpps...pslDhloltppL.....cppsplcp.h.uGhsYLspLspssso...ss.slptYAc.llp-	................................Ppsl.-AEpuVLGulhl......c......s-..th.s...p.l...t..-..h..l...p....scDFYpts.HchIF.pshhcLhpps........csl.Dh.lT.l...tppL.........pp..ps.p.L.c.p....l....G.....G...hsYL.....s.cL....s.ps.s.Po....uA...NlphYAc.IVp-.............................................................	1	376	752	973
+219	PF03796	DnaB_C		DnaB-like helicase C terminal domain	Bateman A, Eberhardt R	anon	Pfam-B_1000 (release 2.1)	Domain	The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerisation of the N-terminal domain has been observed and may occur during the enzymatic cycle. This C-terminal domain contains an ATP-binding site and is therefore probably the site of ATP hydrolysis.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null --hand HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.57	0.70	-5.50	36	6233	2012-10-05 12:31:07	2003-04-07 12:59:11	10	50	4730	57	1194	6420	5596	259.00	43	57.26	CHANGED	GlsTGah-LDphos..Ghppu-LIIlAARPuMGKTAFAlslApslAhcp..............p.tsVulFSLEMuscQLshRhluspupl.......ssppLRs.Gpls..cc-ap+lspshspLscts.laIDDosslolsplRu+sRRL+pp..tslslllIDYLQLhpust...ts-s.....RppElopISRuLKsLA+ELslPVlALSQLSRslEpRs.DKRPhLSDLRESG.............................................................................................................................................................................................................................................................................................................................................................................................................................................uIEQD.....ADlVhFlaR--hYpp................cspttt..................................hsElI.........luKp..RsGssG.............oVp.....LtFpspas+Fssltt	...................................................................................................................................................................................................................................................................................GlsTG.ap-L.D.c.........h.T..u..G...h....p.t.u-.L.....IIlA........ARPuM..GKT.sFA....lNlups.s.A...h....p.p......................p....tsVs.lF..SLE.....M.u.u...c.......Q.....l...s...h....R......h.........l...u.....u.....t......u.pl.........................st.p+..l.....R......s......G......p......L...s.............-...-...-...............W............t.....+...l......s...t....s...h....s.......p......L........p....c...t........s......l.a..I..D......D.....o...s...u........l...o....h...s..-....l..R.........u.+....s....R....R....l....t..............p...................c....................t.........s.......l.s......lI.lID.Y....L....Q....L....h.p.uss.............ts-s...........Rp...pE.l.uE...I.S...RsLK.s...LA..K....EL...plPVlALS....QLs.R..u...l.............E....p......R...............s................D.......K....R.....P....h...h.........S......D..LRE..S...G..............................................................................................................................................................................................................................................................................................................................................................................................................................................u...I.E..Q.D.....ADllh...F.lY....R....-....-..h..Y.p..p...............p...s...p.t..ps........................................................hsElI...luKpR.N.G.s.h.G.....o.Vc...LtF.tpas+Fssh..t.........................................................................................................................	0	402	793	1014
+220	PF00226	DnaJ		DnaJ domain	Birney E, Finn RD	anon	Prosite	Domain	DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction.  DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.02	0.72	-4.23	257	27964	2012-10-01 22:35:57	2003-04-07 12:59:11	26	628	5589	64	12023	23598	6923	62.00	36	16.78	CHANGED	-aYclLGlsp.........sAopp-IK+AYR+LAhpaHPD+Ntsss.......................ApccFcclscAYclLoDsp+.RptYD	............................................shYplL..Glsp.............................sA..s.....t...p.-....I....K.........+...A...YR...+L..u..h........c...a.....H.....P..D+sssss...........................................................Apc+.....F.p..........c.....l.......s....c.....AY..-........l.........L.s.D.pp...Rt.YD....................................................................	0	4164	7147	9951
+221	PF03351	DOMON		DOMON domain	Aravind L, Coggill P	anon	Aravind L	Domain	The DOMON (named after dopamine beta-monooxygenase N-terminal) domain is 110-125 residues long. It is predicted to form an all beta fold with up to 11 strands and is secreted to the extracellular compartment. The beta-strand folding produces a hydrophobic pocket which appears to bind soluble haem. This is consistent with the predominant architectures where the protein is associated with cytochromes or enzymatic domains whose activity involves redox or electron transfer reactions potentially as a direct participant in the electron transfer process. The DOMON domain superfamily, of which this is just one member, shows (1) multiple hydrophobic residues that contribute to the hydrophobic core of the strands of the beta-sandwich, and small residues found at the boundaries of strands and loops, (2) a strongly conserved charged residue (usually arginine/lysine) at the end of strand 9, which possibly stabilises the loop between 9 and 10, and (3) a polar residue (usually histidine, lysine or arginine), that interacts or coordinates with ligands [1]. The suggested superfamily includes both haem- and sugar-binding members: the haem-binding families being the ethyl-Benzoate dehydrogenase family EB_dh, Pfam:PF09459, the cellobiose dehydrogenase family CBDH and this family, and the sugar-binding families being the xylanases, CBM_4_9, Pfam:PF02018. The common feature of the superfamily is the 11-beta-strand structure, although the first and eleventh strands are not well conserved either within families or between families.	25.40	25.40	25.50	25.50	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.66	0.71	-4.19	83	1117	2009-09-13 17:03:55	2003-04-07 12:59:11	12	71	205	0	875	1100	7	114.80	18	23.84	CHANGED	ps..sphplpWphs.tspplphplp..sp.....ssasulGFSs...pst.MsssDhllshsp.s...upsplpDta..........sssts.sphD...p.....pshphhs...st.psshhphpFpRplso.....s-s.pDhtl.tsssh.plla.AhG	............................................t...th.ltaph.....t.....s.p...t.l.phplp........sp........ssaluhGhSs............stt..M.......s.su.D.hhlshhs.s........sps..h.lp-ha....................sssp..s....sphD....t..............psh.ph..hp.................s.t.....p...s.s..h..h.hhpF.p.....R.lts.........s-s..t-h.l.....stsh..hllhu......................................................................	0	378	488	741
+222	PF04124	Dor1		Dor1-like family 	Wood V, Finn RD	anon	Pfam-B_12640 (release 7.3);	Family	Dor1 is involved in vesicle targeting to the yeast Golgi  apparatus and complexes with a number of other trafficking proteins, which include Sec34 and Sec35 [1].	19.80	19.80	19.80	19.90	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.94	0.70	-5.98	7	407	2012-10-03 17:31:52	2003-04-07 12:59:11	7	12	287	0	282	582	28	253.10	23	60.75	CHANGED	lpcLsspsl-pLc+...c.ttLsp-ttpl.tphpsLuhsNY+shlcsAcsppshhpphss.ctphssLhppl......................scLpptspcF.ppupplsEp.....p+hsphhhpppsplh-lLElPpLMs............................pClcpu..haccAL-LpuaspRLppphsp...PllpslssplcpshtphLspLlppLcss.lpLspsl+llsYLR+h.sshscsp.LRhpFLps..p-thLps....hlp.ls.sss..hlpphIphhRsphachlhQYhulFs..-ssh........h.sp.shssstlhs.ashsphoshhphlEthl.+t...lus.lcplhhphhhht.uFthsstDhcuhhs.hhpphlhpphppslppsh-	..............................................................................................................................h.p.......lt.p.tth..phptls....tpht.hlts...tpt....th..t..h...t.h....ttp.htt.l.....t.t.l.....................................................................thtt.......t.h....th....p.t..t.p......pp.........................p.p.s....hhpp.pp..l...-....lL-.lPpLhp....................................tshpt..s.............app.u.l.p..l..ta.hp.p.L...tp.............hh........s....p..............s......lhp..........tl.....tps.t..t...h.t.hh.t.p.Llt...L.p.t......lpL....stsl..+.hlsaLR+.h....s................h............p................t................p....hp...........hhtt......ptthhtt............................................................t.s..........hl...p+hlph...hR.phas....hls.Ypsl...Fs....pt....................................t.........th...........s.tlhp...a.....p.ht.h.h...ph.lct..L.ph............t.thpplh.phhhhs.uhshhshDht..h...............................................................................................................................................	0	96	157	238
+223	PF04173	DoxD		TQO small subunit DoxD	Kletzin A, Studholme DJ	anon	[2]	Family	Swiss:P97207 is a subunit of the terminal quinol oxidase present in the plasma  membrane of Acidianus ambivalens, with calculated molecular mass of 20.4 kDa [1]. Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation.  A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Swiss:Q8AAF0.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.96	0.71	-4.57	7	130	2012-10-02 13:32:46	2003-04-07 12:59:11	8	6	104	0	41	859	161	154.60	30	51.50	CHANGED	ah..lRlslGhhahsAhlR+tlLpPuKLsPsSouYVGtKhlpFLPpu.ushKshL.hll.s.sLLhshLlhFohlEhlhGLhhllGhhTRLsulsshshuhGhhLuAhWLGoTC.DEWQIuhLhsuuuhhlhhoGutph.ulDhlLh+Khpp...t.hlhlhp.........al.Lh	................................................................h.lRhshGahahsuhhR+h...l....h...t....s.....KLsP.s.u....stalG.Kh..p......aLP.pu.....hs.......h.....+....s........hl.thll.s.sl....L..a.......th.h....l..lF.oh...l...Eh.lhG.Lh.lllGlhTR....L...s...u.......l.......s...s........h...h....L....u....h....s.......l...h........L........u........u........u.....W..h..G.s.......T...C...h.....D.......E....W.......p....l.....u......h...l..h.....h.....u.su....h.sl..h..h..s..G...uGt.a...SlDhh.lh.p+ht......................hhhh............................................	0	17	29	37
+224	PF00930	DPPIV_N	DPPIV_N_term; 	Dipeptidyl peptidase IV (DPP IV) N-terminal region	Finn RD, Bateman A	anon	Pfam-B_1017 (release 3.0)	Family	This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.13	0.70	-5.86	43	2539	2012-10-05 17:30:42	2003-04-07 12:59:11	16	64	1098	252	1068	2839	947	293.20	19	41.08	CHANGED	SsDtphlLlths........hpp.aRaShpusaalaDlps...........tphppLsss...........t.lphspaSPs..GptluaVhsNNlYlp...phsss..pthplTs..DG.....psslh.....NGlsDWVYEEE.huspsuhWWSPDup..........tlAahchs-otVshhphshassptt..........YPcshph+...YPKAGssN.spVpLhlhsl...psspsh......pltsss..tsp..DhYlspVsW..ssc.....sc..lhlphhsRtQsthplhhs...-h............ts.spsshhp.......p-ssssWl....chpptshhh.........pssspalhhsp.+sG....apHLhhassssp.....................t...tlTpGsW-V....hp.lhuhDtppshlYFtusc..cs....Ptp+plYplshp.......ssph..ppLosstspp........sssFSss.spaalhsapuPssPh	..................................................................................................................................................................................................................th...sst...s..........p........l........s....ah..................p......t......s.....l....ah......................t..tt..........t.htlT..........su...........hh...........................G....s.....t...h.....hh......p...............-..E..........h......t......................u.......h.....h...Wussup...................................hlhh.hphs.p..s.l..h..h....................................................t..th.........Y.Ph..........sG...t.....s....s.hp....l.hh.h.ph.........tt.t............................................h.....................t.............h...l......s..t...htW......ss......................tp..hh.h.hhsR....p..p...lhhh.....s................................................................................tp...tt.....hh.............................ppp.st..tal.........p....t.t.hhh....................................................sspph..hhh.p....+s....G.......ap....HLahhshsstt..................................................................hp.....tlT.....p.G.p.apV..........................tp...hht...hs...pp...pp....h...la...Fhusp.....pp............sh..p.....p.....p...lYp.l.shs................................ssth....ppl.o..s.p.t..spp..............................s.ss.hSs......s.....t.p.....ahl...hp.s.t....................................................................................................................................................................	0	360	605	877
+225	PF05186	Dpy-30		Dpy-30 motif	Wood V, Bateman A	anon	Pfam-B_13490 (release 7.7)	Motif	This motif is found in a wide variety of domain contexts. It is found in the Dpy-30 proteins hence the motifs name. It is about 40 residues long and is probably formed of two alpha-helices. It may be a dimerisation motif analogous to Pfam:PF02197 (Bateman A pers obs).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.99	0.72	-4.47	14	749	2012-10-01 20:11:07	2003-04-07 12:59:11	8	40	244	4	498	708	14	41.20	37	11.81	CHANGED	ss+pYLspsVsPhLlpGLstlA+pRPpDPlpaLApaLh+pps	..................h+pYL.p.p.p.Vs.PsLhpGLs.pls......+..p........+P...s......DPl...c.aLApaLhcpp.......	0	197	267	394
+226	PF01414	DSL		Delta serrate ligand	Ponting CP, Schultz J, Bork P	anon	SMART	Domain	\N	28.90	28.90	29.50	28.90	28.40	28.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.66	0.72	-3.97	18	522	2012-10-03 09:47:55	2003-04-07 12:59:11	14	157	113	2	298	473	0	61.00	42	8.53	CHANGED	Wppshasusps....clcYphRssCD-pYYGpuCspFCRPRDDtFGHaoCsppGpKhC.sGWpGp.C	..................Wpt...tsths.....plcaphRlhC.c-pYYGp..sCspaC.+P....R.D.D.h.FG.HYsCs.p.s.Gs+..sChsGWpG..C...........	0	117	141	227
+227	PF01666	DX		DX module	Hutter H, Bateman A	anon	[1]	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 6 conserved cysteines that probably form three disulphide bridges.	25.00	25.00	25.70	25.70	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.98	0.72	-3.54	5	33	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	5	0	33	30	0	78.20	28	17.46	CHANGED	PYhTppKCospcsIPhc.t.auFCDsDTGRluILGchpl......cGs-Np-sc.RYCooN+DCoso....oVCVh........hssssupCascP	.......YpTshsCssspslstsap.auFCcs-Tp+lhllGphsh......sGpch...pchp..ppCshNpDC...up.s....pV.CVh...........s.ppthCa.sP.............................	0	7	12	33
+228	PF00782	DSPc		Dual specificity phosphatase, catalytic domain	SMART	anon	Alignment kindly provided by SMART	Domain	Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.73	0.71	-4.57	24	6758	2012-10-02 20:12:17	2003-04-07 12:59:11	15	122	1439	108	3888	7101	596	125.70	20	31.76	CHANGED	lYLuutssst....shhpthslshllNlstths................sphphhplP.lpD..........ppssplstahspshpFIc.ps...ppputpVLVHCtAGlSRSAolslAYLMpppsh.shs-Ahphl......+p+R.stlsPNhsFhtQLhpacpp	................................................................................................................................................tt...tlph...l.l..s.hs.....t..................................................t.t....h....p.h..h.p.l...h.D.............................................................tt....sh.......t..h....h......p...p....s....h..p..h...lc....ps...................pp..p...s........s........p.........V....l..V..H.........C....t....s...G........l.uRS........us..........l.........l....h.....A.....Y.....L....h.......p............p......t.............t.............h....s.............h...........p..-.A.h..p.h.l.....................+pp.R....s...h..h.........s.....s...ahttL......t..................................................	0	1325	2005	2947
+229	PF00035	dsrm		Double-stranded RNA binding motif	Eddy SR	anon	Published_alignment	Domain	Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localisation of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.	23.00	21.00	23.00	21.00	22.90	20.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-9.21	0.72	-3.39	110	8915	2012-10-02 17:51:51	2003-04-07 12:59:11	20	142	4747	68	3095	7369	1675	65.70	27	21.06	CHANGED	sts...hLpc.hspptt......hthththhtppssspt...tFts...plpl........ss.pths....pGtu.......p.sK.KpAcppAAppuLppL	...............................................KotLpE.hhp.t.pt.....................hshtap.h.lp.ppGs....s+p....p..pFss..............plpl.......................ss..pp..hs.........pGpG.............p.SK.KpAc......ppAAppALp..............	0	830	1497	2299
+230	PF01951	Archease	DUF101; 	Archease protein family (MTH1598/TM1083)	Enright A, Ouzounis C, Bateman A, Anantharaman V	anon	Enright A	Domain	This archease family of proteins [1], has two SHS2 domains [2], with one inserted into another. It is predicted to be an enzyme [2]. It is predicted to act as a chaperone in DNA/RNA metabolism [1]. 	25.00	25.00	41.10	41.10	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.78	0.71	-4.22	96	503	2012-10-02 11:08:51	2003-04-07 12:59:11	11	6	472	2	280	485	93	134.80	29	85.80	CHANGED	acal-H..TADltlcuhGsoLcEsFpsAuhAhhslhs.-hsplc...........sc.cp...hclplp.upDh-sLLacaLsELlahhcsc.thlhpc...hclp.hs..........................................thplcupshGEphc.p+Ht..hts-lKAlTYathc............................lpp.psst..........................apspsllDl	..............achl-H..TADlt.lcuaGsol-EsFppuuhuhhshhs...D.hsplc...........st..pp.....hplchp....ucDh-sLLacaLsEllahhss.c...thlh.pc....hclp..hc.............................................thplcupshGEphsht..+H....t..sElKAlTYpthp............................lpp..ppst..............................acstlllDl......................................	0	104	172	233
+231	PF02575	YbaB_DNA_bd	DUF149;	YbaB/EbfC DNA-binding family	Mian N, Bateman A, Eberhardt R	anon	COG0718	Family	This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure [1-3]. The conformation of the DNA is changed when bound to these proteins [3]. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage [1].	25.20	25.20	25.20	25.30	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.97	0.72	-4.10	139	4505	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	4084	9	1047	2557	1477	92.10	35	83.07	CHANGED	hcQApp.hQpp....hpchQccLsphplpGpuGuG....hVpVphsGctclhslpIcspll.c......-DhEhLpDLlhuAhN-Ahp+scphtpp...chsphou.Gh..shP	..................................MKQAQp.MQcc....MpchQc-L....up...hclsGpuGuG....lVpVoh....s....G....ppplpclcIcssll...-...............-DhEhLpDLlhuAhN-Ahp+s-ctppc...chuphou.Gh.t.........................	0	372	713	898
+232	PF02580	Tyr_Deacylase	DUF154;	D-Tyr-tRNA(Tyr) deacylase	Mian N, Bateman A, Moxon SJ	anon	COG1490	Family	This family comprises of several D-Tyr-tRNA(Tyr) deacylase proteins. Cell growth inhibition by several d-amino acids can be explained by an in vivo  production of d-aminoacyl-tRNA molecules. Escherichia coli and yeast cells express an enzyme, d-Tyr-tRNA(Tyr) deacylase, capable of recycling such d-aminoacyl-tRNA molecules into free tRNA and d-amino acid. Accordingly, upon inactivation of the genes of the above deacylases, the toxicity of d-amino acids increases. Orthologues of the deacylase are found in many cells [1].	25.00	25.00	25.50	25.50	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.71	0.71	-4.21	37	3993	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	3782	94	988	2599	777	142.60	45	94.69	CHANGED	+sVlQRVppApVsV....-sc........llGpI....spGlllLlGltcs.....Dop-chchhscKllslRlF.....-D-psK.hNhSlpDls.GplLlVSQFTLhu-spKGpRPsFppuuss-pAptLY-pFsphl+pts..............................pVcsGpFGAcMpVpLsNDGPVTlll-s	.........................................+sllQRVppAsVs..V..........................-uc............lsGp.I.........spG....LllLlGlpps.....................Ds....c.....p.....cs.....c.....hl...........scKlhshRlF......................pD..-...p....G..........K.....MNhSl.p-l.............s.....Gp.....lL...l................VSQ..FTLhADT.+K.Gp.R.PuFsp.....AAs....P-tAptLY-hFs.p.p.h+ppt...h............................pVpTGpFGAcM.pVs.LlNDGPVTlhL-............................................	0	335	604	813
+233	PF02583	Trns_repr_metal	DUF156;	Metal-sensitive transcriptional repressor	Mian N, Bateman A, Eberhardt R	anon	COG1937	Family	This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [1-5].	21.20	21.20	21.30	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.84	0.72	-3.79	147	4323	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	2741	7	851	2245	340	83.60	30	88.61	CHANGED	tpp+ccll.pRL+RIc...GQlcGl.p+Ml.Ep...cc..Ch-lLpQluAl+uAls....pltthllcsHlcpClt.pshps.......tppp...ptlcElhphlp+h	...........p+ppll...sRL+RIcGQlcul.p+Ml.Ec.....c.c...Ct-lLpQluAl+uAls....slhtt..llcpHlp.cCls..pshpp.........tppc...pplc-hhphlpp..............................	0	298	568	728
+234	PF02588	DUF161		Uncharacterized BCR, YitT family COG1284	Mian N, Bateman A	anon	Yeats C	Family	This is probably a bacterial ABC transporter permease (personal obs:Yeats C).	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.64	0.72	-3.68	189	12563	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	2439	0	2056	8039	1861	84.60	21	58.10	CHANGED	phlhhlhGuhlhuhGhshhhtss.hssGGhssluhllp.phhs...................lshuhhhhlls.lslhlhuhhh...................................h............ph.........................................................slhollshhlhuhhl	.....................hlhhlhGuh.lh.ulG.l.s.hh.htss.h..ssGG...hssl.uhllp..p..hhs...........................l.s.h.uhhh..hh...lN.hsllll.uhhh.........................................................................h............sh.................................................................................slhollshhlhuhh......................................................................................	0	729	1389	1730
+235	PF02639	DUF188		Uncharacterized BCR, YaiI/YqxD family COG1671	Mian N, Bateman A	anon	COG1671	Family	\N	24.30	24.30	24.30	24.70	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.41	0.71	-4.70	167	2006	2012-10-03 20:43:45	2003-04-07 12:59:11	9	4	1980	0	382	1203	282	129.60	39	85.25	CHANGED	hlh+sApRtpl.lhlVANphlphPs...............p.shlctlhVssGhDsADshIscpspsGDlVlTuDIPLAucllpKGuhslsP+GchaopcNItptLshRchMpclRsu..Gh.......o.GGPssauppDRppFtssLD+hlt+	...............................lh+sAcRhp.l.lslVANps..h.t.s.ss.............................p..phlcslhV.ss.GhDsADpcIVppscsG..D.....l..VITtDIPLAutllcKGu.hsLsP+GchYosssIcptLshRshhsplRtu.....Gh....p....TuGP.sshopcDRptFtspL-+hl................	0	115	236	310
+236	PF02641	DUF190		Uncharacterized ACR, COG1993	Mian N, Bateman A	anon	COG1993	Family	\N	20.50	20.50	20.50	20.50	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.33	0.72	-4.14	5	725	2012-10-01 21:59:08	2003-04-07 12:59:11	10	8	534	4	284	539	18	99.30	27	76.82	CHANGED	lKpKLLRIYouEs-+aEGcPhYKsllc+L+E.cGIcGATVaRGIsG.YGK++clHuc-lFpLSscLPVllElVDccEsIpRsLccl+EhhKs.GLITlEcVcVh	.............................t....hLplahuEp...c+......h..p..u.cP.la.c.tllchh+c.tul.A.G.AT.VhRGltG..aGp..pp.h.l.Hs..schh.pL...u..p...c.lP.l.slphVDstcclpthls.p.l.p.phh....pp....u...LlTh-.s...h...................................	0	107	189	248
+237	PF02958	EcKinase	DUF227;	Ecdysteroid kinase	Bateman A, Eberhardt R	anon	Pfam-B_2081 (release 6.4)	Family	This family includes ecdysteroid 22-kinase, an enzyme responsible for the phosphorylation of ecdysteroids (insect growth and moulting hormones) at C-22, to form physiologically inactive ecdysteroid 22-phosphates [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-12.02	0.70	-5.27	54	1726	2012-10-02 22:05:25	2003-04-07 12:59:11	15	28	286	0	1069	4192	1235	241.30	19	65.13	CHANGED	pG-NYsShhhRlplch.........p.spsppp.......hohllKs............h..tpstttphhp.phtlFppEhshYppllPchcplh.cps.............s..hphhscshhhp.....tp.p....phllhEDLs.pGapsssR.hpsLsh-cschslcKLApaHAsShshtp...p.s..htph...pGhhppthhps......pshh...pshhpshhchh.pphsththht.....p+lpplts..phhcphhphhp..........sssspasVLsHGDhWsNNlMFcYcsps...p.p-shhlDFQhspauSPuhDLhYhlhoSsp.-h.+hpph-pllphYappLhc.pLctLsa	.............................................................................................................................................................thhs.hhph.h.h..................t...t.t.....p..................hshhlKh.........................................tp.......hht....t....t..h..a....t..p..Eh.....hY..pp..hhP..thtth.tt.............................h..hspshhsp.................................t............hll..h.EDL....p..........t....u...a..p......h.s.c...ht.s.h......s......hpc....h.ph.slppLAphHAhoh...shtp..........p..........................t......h........s...h.h....t..t........h.....t..t..........................t.....h..h........t..th..h.p..t..hh.p...h.h.......t..t...........t.h.........................................tth.p.t..h....t......p.h..h...p....h..h.p.hht................tttth....p...s...l....s.....HGDha..............hs..Nhha.......p.......h.........s......tt......t........................................p...........s............h...hlD...........a....Q..hsthu....s....s....shD....l....h...a....h...l...h......s...s...h....p......ph.....p...............pp...h....pt..h.l...phYaptLhp.lt.....................................................	1	287	431	878
+238	PF02995	DUF229		Protein of unknown function (DUF229)	Bateman A	anon	Pfam-B_1566 (release 6.4)	Family	Members of this family are uncharacterised.  They are 500-1200 amino acids in length and share a long region conservation that probably corresponds to several domains. The Go annotation for the protein indicates that it is involved in nematode larval development and has a positive regulation on growth rate.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.73	0.70	-6.08	17	540	2012-10-03 20:55:17	2003-04-07 12:59:11	12	17	54	0	424	1427	722	390.00	22	71.40	CHANGED	c.hphppCspsp.hhspphs.phpphhlphpt.....hh.....tshpChY.pphtRtpst...pshhhh.phhth...hppsh.l.ss...................................s-hhpspChp.shsphh.............pDshtalpp.....ph..p.............ptpss.ptcc.SVhllGlDSlS+hphhRphP+shpalp.phsahEh.GYNKVGDNohPNLlslLoG...........hsp.thptsp....psttshDphsaIWKpFppt.GYtThauEDt..sshssFsY.....p.GFpcpPsDaYhRPhhhthEpphphhtp.ths....ChGp+.tpphlh-ahtpFh.+apsph....hFuahWssphoH-.hphssth.................DcthhpaLpphccpuhh-solllhhSDHG...........................................................hRaGphcpsh....pGhhEERhPhhhlhhPpah+..cpaPphhpNLphNpc+LoosaDlHtTLccllpLsshsctphps...t.ps.............+shSLFhPlPpp.RoCtpAsI.p+aCsCpshpplssss.....hhpphuptlVpplNchlts.........pthCpsLpLpplp	..........................................................................................................................................t.................................................................h.C.h.....h.h.........................................................t.....................................................................phh.h.C......t.............................hh..............................................t...sVhhhslDShSphp.hh.R...............p..hPcshp........al........p...p...............................s........h......h.ph..uaN...p........l.u..-soh..sNhhslhsG............................stt.th.t.h.......t.t.hDth.s.hla.ppapp.......t.GYh....Th....a....uED..............ths.h.ap..................h.GF...p..P.s.....D..aYh.....R.sh....h....h....t..hp..p......ht..............th...................C.h.s.tc..hphhh-..a.h....t............phh.tt.a....pp..................hFuh....h..a.....s...p...h....sH....s...h.p.hh.thh.............................................................Dpt...hh.phl.pp.h.pp..p.t..................................hpp..ohllhhuDH.G.......................................................................................................................................................hR......a..u.......t..h.t...p.t.................pG..h.h...E..c....p.....Ph...hh.l...hlP.hh+..............pp..h.sphhp...sLp.Npp+Ls...............os...a.Dl+tT.L.......hcll.p.htt.....t......................t.......................................ps.S.Lh....l.P.p..RsCt.ps.s..I.....p.aChC......ht..t.h....p.p............................h.thuphh...lt.......hNphh.t....................Ct.hplt...h.........................................................................................................................................................................................................................	0	173	212	373
+239	PF01697	Glyco_transf_92	DUF23;	Glycosyltransferase family 92	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1694 (release 4.1)	Domain	Members of this family act as galactosyltransferases, belonging to glycosyltransferase family 92 [1,2]. The aligned region contains several conserved cysteine residues and several charged residues that may be catalytic residues. This is supported by the inclusion of this family in the GT-A glycosyl transferase superfamily.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.81	0.70	-5.10	52	812	2012-10-03 05:28:31	2003-04-07 12:59:11	22	17	132	0	706	894	66	240.60	15	52.56	CHANGED	+slslCluPlass-s....phhpalphh+lt..Gus+hhlYhts.hspphhpllcpY.pct...Gh.lplp.a..................................hp.ptph.h+spthuhsDChlp..h+ttscahuhhDlD-hlhsps..phh.....pphpphhpshts.phhthphpstthhp..tp.hssh...sh..h............................t..................................KsllcPpplsthhhHhshph.t.....................s.thhplpp..h.....cs.p.............................................................................hhpht...phhtch.hpphhhshhhpshppphht	.....................................................................hhhCh.t.shhht....t....plhpalth.hphh................Gs..s+h.hh.Y....ts......h...sp.p..h..hc..l..lc....Y..pt...........G.h..l..p..l...h..sh................................................................t.p..t.th..h..hts..phhsh...sDCl..h+................p.............t......p...s.......c........ahshhDlDEhl....h..s....hp..........................p..h...t....ph.h.p...p...h...t...............t...........h........t...t......h...t........hpphhh....t..........t...t..hs..th............t....t...h...p.h.hh.th........t..t...............................................................K.hlhps.....ptl.....t..h.h.h.H..h.....sh.phh................................t.h..h..........h...Hhp...................................................................................................................................................hh..........................................................................................................................................................................................	1	240	340	659
+241	PF02996	Prefoldin	DUF232;	Prefoldin subunit	Bateman A, Moxon SJ	anon	Pfam-B_1664 (release 6.4)	Family	This family comprises of several prefoldin subunits. The biogenesis of the cytoskeletal proteins actin and tubulin involves interaction of nascent chains of each of the two proteins with the oligomeric protein prefoldin (PFD) and their subsequent transfer to the cytosolic chaperonin CCT (chaperonin containing TCP-1). Electron microscopy shows that eukaryotic PFD, which has a similar structure to its archaeal counterpart, interacts with unfolded actin along the tips of its projecting arms. In its PFD-bound state, actin seems to acquire a conformation similar to that adopted when it is bound to CCT [1].	23.20	23.20	23.20	24.00	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.16	0.71	-4.46	37	1254	2012-10-02 17:27:01	2003-04-07 12:59:11	12	25	488	2	812	1220	90	116.60	19	50.84	CHANGED	hcttlpplpsphsplppthsclcpshpslcslpp........spshchhlslusslahpupl..cssc.....lllplGsshhlEhshc-Ahchlcc+lpplpcphcplppplpplppphsphttphpphtpp	...................................................p...tphppphpplptthsc....hppsh.cslpplpp..........................tppsh.c...hhl.sl.s......ss..h.a......sp.............upl..ss..s..sc............................Vhlt...lG..ss..hhlEhshc-Ahphlcc+.....lptlp.pplcp....lp....pplpt....h....ppphp...hht...htph.........................................................	0	274	444	656
+244	PF03080	DUF239	DUF239; Glucoamylase;	Domain of unknown function (DUF239)	Griffiths-Jones SR	anon	Pfam-B_913 (release 6.4)	Family	This is a family of plant and bacterial proteins, a small number of which are putative carboxy-terminal peptidases (see for example Swiss:Q9XIN9).	22.00	21.50	22.40	21.90	21.70	21.30	hmmbuild  --amino -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.71	0.70	-5.28	54	602	2009-01-15 18:05:59	2003-04-07 12:59:11	10	22	47	0	366	574	2	189.70	33	56.66	CHANGED	aaGspAslsVasPpltp..t..paShuplal.sGs..stp...hssIpAGWtVpPplaGDspsRhasaW...cshpts.GCYNhhCs...GFV.Qsspp.lslGsslpssSs.hsst.p.htlphhlh+...D.psGNWWLp..h.ts........hlGYWPupLFsp..lsst.AshlpaGGpVhsst......st..pssP.MGSG+.Fstp.s..htcAuahpslp.llDtss...phhss......psh..hssp.p.CYslpsht.......................hGth..haYG...GP	.............................................hhGspuslslap.Pplpt...s...phShuplalhsGs...ttp..............hss.IpsGWp..............V.........PphY...s...Ds..ts+hahaW....o.............t............-............sh....pts....GC.a....Nh...Cs....GFl.Qs..s.pp..hshGss.lt...shSs....hsut.p....htlplhlap.................D.tpGsWWlt....h.sst......hlG.....YWPttLFs..........lt.p....t....As.hlpaGGplhssp.....s..sss...MGSGp....astp...s...htpuuahpslp.hhstst...phhs.........h...hsppsp.CYslt.h...................t..t.h.hhaGGP.................................................	0	63	183	236
+245	PF03087	DUF241		Arabidopsis protein of unknown function	Griffiths-Jones SR	anon	Pfam-B_1563 (release 6.5)	Family	This family represents a number of Arabidopsis proteins. Their functions are unknown.	23.10	23.10	23.20	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.62	0.70	-4.87	11	556	2012-10-01 23:20:42	2003-04-07 12:59:11	9	4	17	0	392	492	0	161.50	25	80.30	CHANGED	huLusLpELYcslpchLchssoppthtppp....hhEchLDuSlclLDlCussRDlhspl+EplpsLQSuLRR+c..ut.....lcsclcuYls.RKpl+KEhpKhltuLKphpst.............t...ptsslsslhcpshtholslh+olhphLSs.....scs.h.hpstLhshhhhppstt.pstt...............hcsEhpplDtthpt....sppphhcclcphEhs...........lc-lEcpLEuLa+pLIpsRVSLLNI	..............................................................t.....h.tlh.thtphh.hs...st.....................h-t.h-t.l.llDhpsh.hp-.h.th+t.htphp.sl++tc.....................tspl.t..t.hht......h.+ph.p...Ktht+..h.tthtt.t.............................................hhthhtps...hsh....shh.pshh..hlst...................th.h.hsphh........p.t...................................................................................................................................................ppl.p.tlc.s...............................................ltthEttht.laRpLlpsRs...slLN.......................................................................................	0	16	176	308
+246	PF03103	DUF243		Domain of unknown function (DUF243)	Bateman A	anon	Pfam-B_1157 (release 6.5)	Family	This family of uncharacterised proteins is only found in fly proteins. It is found associated with YLP motifs Pfam:PF02757 in some proteins.	25.00	25.00	51.50	46.00	19.40	23.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.57	0.72	-3.87	31	401	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	29	0	246	417	0	96.70	39	34.43	CHANGED	llpKchYlHssP.--.E-......tptth.susspKpY+llFIKAPss..ssspAslthspstsEEKTllYVLsKKs-ttp.sttls.s.tsspsuKPEVaFIKY	.........lpKcFYsasAP.E-s.-p.....ts......tphh....susspKsh+VlFIKuPps..sh.psA.s.lthsp.tssEp+TsIYVLsKps-.sshsp.pls...s.psspssKPEVaFlKY.............	0	45	60	165
+247	PF03140	DUF247		Plant protein of unknown function	Mifsud W	anon	Pfam-B_1292 (release 6.5)	Family	The function of the plant proteins constituting this family is unknown.	24.80	24.80	24.90	25.50	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.35	0.70	-5.46	48	1014	2009-01-15 18:05:59	2003-04-07 12:59:11	10	19	25	0	634	924	0	301.50	22	82.37	CHANGED	IaRVPtpl+.ch..sp.cuY.pPplVSlGPY.H+u..pppL................psMEpaKhRhLpphls+ss.............tslpphlsslpslEpcs.Rss....Ys-sss................hssc-...FlcMllLDGCFlLchhhthsp......................stsDs.lashphhhsh...l..ppDhlLLENQlPaFVLccLhphhp.................................ttpspssLsplshp....ah.............t.shthss......thhtptps............pHlLcLh+pshl......ss.tp......tsttshpp.t...........................................phlhsAs-LcpsGV+F..+ppcs.............sp........................hhD.lpF..c....pG.s......LclPplhlc-sTpplhtNLlAFEQs.psss...............sshlTuYlhFMssLlsoscDVslL.pccGllcshlGs-.....p-Vuc.hFsp.Lscs......ss.hs.hcs...salss....lhpplspappp....php.....phhApl++.paFssPWshhuh...lAAlllllhT	.........................................................................................................h...h.........p....t.a..PthlulG..P.h...+tt......t.th...........................h-phKhhhhtthhtt.t.......................htthht...ht..t........ph..+t.............Ytt...............................ht.tpp.....hh.hhhhDus...Fll.hh....h.................................................................................t..................h...............l.....DhhhlENQlP....hhl.l.pt.lhth.........................................................................h....thhht......hh...................................................................................Hhh.chhh...hh..............................................................................................................................................................h.s.stpLt.t.sG.lph...t.ttt.........................................................................hhs..lph...p............tu..h....................lp..lP.l.....l.pt..st.hhhNhhAhEtt..t...........................t..hssY...h.hhs.l.lss..pDlthL..hpptl.l......p.h...h...t......s.p............pt.ssp..hhpt.lspt.............................hh..hs..............hh.t.........hht.tlpt....ah.pp.........h.............................hhh.t...hh......a...h...s...h.hhs..hhshhhh..........................................................	0	33	377	521
+248	PF03141	Methyltransf_29	DUF248;	Putative S-adenosyl-L-methionine-dependent methyltransferase	Mifsud W, Moxon SJ, Eberhardt R	anon	Pfam-B_1462 (release 6.5)	Family	This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [1,2].	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.73	0.70	-6.17	22	712	2012-10-10 17:06:42	2003-04-07 12:59:11	11	15	46	0	435	2409	358	380.90	35	73.10	CHANGED	-YhPChDsppshph....spcphpapERHCPs..........pcphpCLlPsP.cGYKsPlpWPcSRDhlWasNlPHs+...LsppKusQNWlphpG-hhpFPGGGTpF.pGAspYI-pluphls.......hsuplRssLDlGC.GVASFGAaLLs+sllTMShAP...+DsHEuQlQFALERGlPAhluVh...uTpRLPaPSpuFDhsHCSRChIsWppp-GhhLhElsRlLRPGGYalhSusPlh.........+pcp-.ppthcchpslscplCWchlsccsp......hsIWpKPhss.sChtp.Rpt..spPslCc.sc-sDssWYsphcsClo.hP-s.......ptsustlp.WPpRLpssPsRlps.....h.t.sh-tFcpDschWpcpVstYhclhp.hlppsclRNVMDMsAshGGFAAALtch...lWVMNVVPs.....ssssTLslIY-RGLlGsYHDWCEuFSTYPRTYDLlHAssLFShhp......pR.Csh.psILLEMDRILRPpGtlIIRDph-llscVcc.lspuh+Wcsphp-p...ccss....pEplLhspK	.................................................................................................hhPC.s.......t.......ht.h..hERpCP..............t...Clls.P..sYt..............Ph.WPtS.......+.......c.h...hhtNh..sa.t...ls....p..t.ppW....h....ptp..hh.....F.P.u.u...u.o.....F...t..G.s..........t..Y...l....p.................l......t.p......hhs...........................st..th...R...s.....sLDh...GC...G...................V....A.......S....a....G...u..h...L....h.....p.....c......s....l...l..s....h...S..h......AP........p..D..t....H....p....s....Q....l......Q......F....A......L......E....R.....G.......l....P......A....h....l...u......s..h.......u..o..p....+.....L.P.a.P.u.p.s...FD..hs......H..C..u..R..C..h...l.....s.....W...t....t......................s....G..h...........h...L.h.Els.RlLRPGG...a..a..l...ho...u...s..h...............................t...........t..t.....pt..h....t.h.....s.pt....hC...Wphh....p..tp......hslapK..sp..pCh......pt........hCp..t.p.ss..s.t...sW......................h.hpsCht..s.............t....aPtRh...s....hltt........t...t.p.att.Dpph.....Wpphltthh.h...........l.........t.......sp...............hRNlhDMpAhhGGFAAA.L..h..p........lW.VMNVVP...................tt.sTLslIa-RGLl......G....hhp........DW...CEuFsT.YPRTY.DLlHAstl..hoh.h...p......p+....Cp.h...lhlEhDRILRPtGh.hllRDp.thl.plpt...hhtthpWp...s...h..h.....t......p................hh.............................................................................................................................	0	54	278	354
+249	PF03164	Mon1	DUF254; 	Trafficking protein Mon1	Bateman A, Wood V	anon	Edwards YJK	Family	Members of this family have been called SAND proteins [4] although these proteins do not contain a SAND domain.  In Saccharomyces cerevisiae a protein complex of Mon1 and Ccz1 functions with the small GTPase Ypt7 to mediate vesicle trafficking to the vacuole [7]. The Mon1/Ccz1 complex is conserved in eukaryotic evolution and members of this family (previously known as DUF254) are distant homologues to domains of known structure that assemble into cargo vesicle adapter (AP) complexes [5]. [3] describes orthologues in Fugu rubripes.	20.40	20.40	20.50	21.20	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.53	0.70	-5.87	7	443	2009-09-11 23:32:11	2003-04-07 12:59:11	9	13	291	0	297	444	4	359.80	32	71.63	CHANGED	s.hsEthptpcKplFlLSEAGKPIaopa.Gs--tlsShhGlhpAlVSahpsst...sslpShpupup+lsFLp+SPLlLVusScospS.stpLhppLthlYtQIlShLTtsplp+lFpp+.pNaDLRRLLuGoEphhcsLl......pphsps..shLhsulpslPLssohR-tlossltp.......sphcsLlFulllAt.s+LlshVRhKchh....LHstDLpLlhsLlus..ps..csuEsWsPlCLP+FNssGFhaAalua.Lss....s.ssCLlLlSscR-sFFshpss+pclhp+Lcc.pthhpsLtcshpp........staplpplG..hPpL+HFLYKs.......KpssQassPthchshpstpEpp.......RL.ulYppLHs+l+p......sRshphhhchsp+-s.................................LhAWVTssF-LYhhhs.PlsoKshslpsVpKLl+Wl+KEEsRLFIhsshoa	..........................................................................t......hptppKHhalLSpA.GKPla........o.pa....G...........s.p....p.....hl.................s.shh....Glhpsl..l....S......ah.p.s..st.......................stlp...sh.......p..u..ss......h...+hV.al..p.cuPLhLVul..............S....p...........h..........t..........po..................t.p...........Lp.....tpL.ph...lahQIlShLThsplp+lFpp+..saDLR.+hLt.Go...-thh.ssLl..................................pthsps....s...s....hl..hs.ul.ps..l...Lt..t.s...hRptlsshl...p.................................spstsllaullhst..spllsl.lp.....+.p..h........................L+PsDLpLlhshl.s.............pt..s....h.........p..............s..u...........EsWhPlCLPp.FNssGahasalsa..lp.......................................thsl....lLlSs..p..+....-..s..F.at....lpp.....h+...ppl........pt...lpp.tsshtt.....lt..puh.pt..........................................hp...h..t...l.s........hs...l.pHFl..YKs........+t.s....Qa..s.....sph......psshtp...t..ppp.................................+.Lhth..Ypp...La........s...ph+s..........................................t.t..h.......+..hhhh.....h..s...ppts..................................................................hhsWh............Ts.FEL..Y......hsh.s.....s.......s.s+.s......hhts.hpclhpWhpppcp.clFl.........................................................................................................	0	103	166	245
+250	PF03194	LUC7	DUF259; 	LUC7 N_terminus	Mifsud W	anon	Pfam-B_2902 (release 6.5)	Family	This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein [1] with a role in splice site recognition [2]. The family also contains human and mouse LUC7 like (LUC7L) proteins [3] and human cisplatin resistance-associated overexpressed protein (CROP) [4].	33.00	33.00	33.50	34.40	32.30	32.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.90	0.70	-4.85	8	689	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	292	0	416	616	10	242.10	34	76.98	CHANGED	sDphRphLDQLMG...osRsscpp+st..l+asDccVC+uaLlshCPHDlFssT+hD.LGsCsKlH-.ph+t-YEpAs+pccah..aEh-hhchlpp.........................hlsDsD++lchu+pRLccspE-pss.sss.p..scpltslscc...........................IschLscsEsLGccGcV--u.clhcclEcL+sc+pcltc..................................................ps+sssPusu.h....................................spQKL+VCElCGAaLultDsDcRLADHFsGKhHLGYsplR-pltELccstsc.........+pc-Rcc+t......hsspRph	.......................................t....tthL-pLMG...........tt.p....s.....h..s.pctp...........lpa.s.D.cV............C+.aLhshCPH-l..hs..sT............+....D......LG................C..............K.l.H...s...........t.....L+tpY....E...t...us...c.p...t....ch.........h.....aEh-...hhchLpp.........................hls-s-R+lchuccRL.....tpop...........cc.....h....s...s...t....s....s...s.p.......tcclppLscc................................Isp.hL.......tc.sE.pL.Gt...pGpV--up.ph.hpclE...pl+tc+cchcp...............................................................................................................................h....p..s.....t.h..s.....s...........................................................................................tppKLcVC-VCuAa..Lul..tDs..-..pRl....s..DHhhGKhHlGahpl..RcplpcLpcphtp......................................ppptptt..............................................................................................................................................	0	139	215	329
+251	PF01657	Stress-antifung	DUF26;	Salt stress response/antifungal	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_980 (release 4.1)	Family	This domain is often found in association with the kinase domains Pfam:PF00069 or Pfam:PF07714. In many proteins it is duplicated. It contains six conserved cysteines which are involved in disulphide bridges [1]. It has a role in salt stress response [2] and has antifungal activity [3].	25.00	25.00	25.20	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-11.24	0.72	-3.70	175	2349	2009-01-15 18:05:59	2003-04-07 12:59:11	12	43	34	4	1517	2447	0	101.20	22	40.19	CHANGED	hphC.....sssth.s.....sss.a.ppslpsllssLss..p.ust..............hassu.......s.......sss....pVYuls.Cps.D.l....s....s....ss..CpsC.lspuhppht....p.C......st....ppsuhlh.....hss.ChlRYs.ts.F	..................................................t...............t........sss.a..ppslp...pl.hs.s..Lss.pssss.....................ttFsssp..................s...st..sss........plYu.lspC.....p..s..D....l.....s......s.....ss....Cp..sC.lss.uhs.pl.......ph.......C.............ss.....pps..u...tlh........hsp...ChlRYp......................................	0	213	869	1163
+252	PF03195	DUF260		Protein of unknown function DUF260	Mifsud W	anon	Pfam-B_2998 (release 6.5)	Family	\N	21.50	21.50	22.10	24.70	21.00	19.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.22	0.72	-3.73	46	709	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	35	0	506	727	0	98.50	43	47.36	CHANGED	sCAACKaLRR.+Csss.ClhAPYF.....Ps..sp.s...ppFtslH+lFGsuNlsKhLppl..sspp.R.....scuhsSlhYEApuRhpDPVhGssGhlhpLppplpphps.-lshspppl	...............................sCuACKhLRR.+Csps.ClhAPYF................Ps......sp..s...p+FsslHKlFGASNlsKhLp....cl.............P..pp..R.....s-AssSlsYEA...........puRl+DPVY.GCVGhI.tLQpplpplps-Lshhpt..h............................................	0	69	316	409
+254	PF03268	DUF267		Caenorhabditis protein of unknown function, DUF267	Mifsud W	anon	Pfam-B_4201 (release 6.5)	Family	\N	25.00	25.00	48.50	36.40	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.07	0.70	-5.60	7	50	2012-10-01 21:54:26	2003-04-07 12:59:11	9	2	6	0	49	42	0	323.90	31	88.29	CHANGED	lLGsa+allKhosLDCSppu........+lpulhsplhslshlshhhhRhhhhhph-upsLohuWAEsNhFuFhulpuhshulsLauWTKsuhlspahp+LtclR.LRlpsNpc.hDpYtph+hchFlaSh.allshhupAIashlp.pKIhhussshs.shhhhh.hh..hhshahshlpLshahLlphulsREhcaFNpELEcAppsKpLpsssllpcFsaRQtcllchlp.sscpLpsasussPLFhahuLhNulalho...hhs.lsslYhIhlhh.LhulIhhshhhLhPAuhVQ-plhpTo+ILMssp-FcpSKDspVYpTYRhMlDRSh+spophhVlsuhsIs.pshphAhFlIPNls	.................................................lhG.achhh+hohLDC.shhs........phpthhstlhulhllhhhhh+.hhhh.hth..pup.LShsWAEushauFhuhpuhhsuhslhsWTppshl.pa.cpLsplRhLRlpss.pp.hDsYptl+h+Ahlhsh..hhsshhupu....lashhp.p+lhhu......sspss....hhahhhshlshlshah..sslsLshYhLlpsulsRElcaFNcELccApccKpL.................ps.slLpcFshRQt-llchlphsNcpLssasshuPhFhhh......uhlNusYlso...F.hsslPslahlhLhh.lhuslhhshhhLhPsutlQcplppTucILhsscphcpspDsplapTYRlMlDRs.+scopltVlsuFslsppshstAhFhlPNls........	0	15	20	49
+255	PF03269	DUF268		Caenorhabditis protein of unknown function, DUF268	Mifsud W	anon	Pfam-B_4252 (release 6.5)	Family	\N	21.10	21.10	22.00	27.00	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.14	0.71	-4.69	6	72	2012-10-10 17:06:42	2003-04-07 12:59:11	9	5	28	0	60	76	45	152.30	40	44.35	CHANGED	DGhSGVVlGShpPWVEVpALppG.......sspILTVEYNs..LsIpEcF+-R..lSSIhPhDFspNacpYusoFDFAASFSSIEHsGLGRYGDPlDPIGDLREMLKIKCsLK.GGLLFLGlPlGpDAl.aNsHRIYGslRLAMMhhGFEWIsTFSG-oEpuhDLoupcL+ccsLFuhsQpTLVLRKL	........................................................pshlhuS...PhhEh.ul.pG..............AtplLolp.s...lph....psp..hooh...-Fspp..a.p.pastp.FDFsuohooIEHsGLGRYGDPlD.PhGDl+thhcl+ClLKpGG................LLFLulPlG.s.DultaNAHRIYGslR.LsMhh.Ga-hlsoaut.ppp...ph..................................................................	0	18	24	60
+256	PF03312	DUF272		Protein of unknown function (DUF272)	Mifsud W, Pollington J	anon	Pfam-B_3609 (release 6.5)	Family	This family of proteins is restricted to C.elegans and has no known function. The protein contains a ubiquitin fold. The GO annotation for the protein indicates that it has a function in nematode larval development.	25.00	25.00	25.10	27.90	23.50	24.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.81	0.71	-3.91	15	49	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	5	0	48	51	0	125.30	30	28.11	CHANGED	FLWlsDpppcolh.pospasLphGHFF-GhFpcpssG.p..WpChcYl+pIctll.cGtlsss......KlplpsslppapPtsssp+.aPpsaucalGhllDsc...sKLstsCs.G+pVplptp+ls...tcpasWhVocll	............................aLWlhDpppculh....ho..........p....papLthGHFFEGhFpcptsu..+............WpC...p.....cYh+tl.pt..L..l..cGslsts......+I.lplplpp.a.pPs.sss.pc.aspshucalGcll...-tp..................s+Ls.tsss.G+...plplphtp...lt...ppsahWhVscl..................................................	0	14	16	48
+257	PF03409	Glycoprotein	DUF274; Glycoprotein_Ce;	Transmembrane glycoprotein	Finn RD, Pollington J	anon	Pfam-B_4416 (release 6.6)	Family	This family of proteins has some GO annotations for positive regulation of growth rate and nematode larval development. This is probably a family of membrane glycoproteins [1].	19.50	19.50	19.50	21.00	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.11	0.70	-5.71	17	125	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	5	0	124	122	0	283.90	24	79.27	CHANGED	s-sshplYl.AuuDcsphLppI...hlTssspshoLspLpss...pssG.hpsas..lsssshloTo.sssshtsLsGhIYloospQtpDss.FtVYslpss.pslshs....sspoTllhLNT.h........stPhtoShlophsQsssoslhhYtGhPtDshpphs......sphFsNPhhhps.........tsphFFssVEshpl.uLssaYl+ohs.slsFhlcstahs...hsshsTTus.sTTGhhMp..spssssh.sVNhtpDss.hs.GsSGs.lsutls..tusloVsh.ssssshppshsssp.hs..saphshhu.pshplsST..sshsGpaYlQYFshpGs..s...oooshssp.sssp..........................................................lpTTTKuusslplhhShhlhhhh.h	...................................................................................sshplYl.ApsDs..sthLppI...hhsssst.ph...........oL.pLtt.....ps.sG...p.sh...lp..s.shhlsos.sss.hptLsGhlYloo.tQhp.....ss................s.F.Vhslptt.p.lpht.......psThlhLNoth...........P...sohlophtQs.ss..h.ha.uhPtst.p..t......p.hFpNPh.h............................haFsplE.hpl.sh.haYhps..s.shph.lpstahs...................ps.hs..Touh.sTTGhhhp..s....pph.slphhp.....D.p.....hsGhsGh.l..........s...h....splsh.....t..s.....t....t..sh...tt.........h.h.h.s.pp..hplps.s..s...s.G.aah.....QYahhps............ss.s..s..............................................................................ooTt......................hh.....................................................................................................................................................................................................................................	0	26	36	124
+258	PF03357	Snf7	DUF279; SNF7; ESCRT-III; 	Snf7	Mifsud W, Moxon SJ, Mistry J, Wood V	anon	Pfam-B_1641 (release 6.6)	Family	This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localisation, requires the formation of multivesicular bodies (MVBs).  These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins [1]. A few archaeal sequences are also present within this family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.96	0.71	-4.87	34	2816	2012-10-03 05:15:35	2003-04-07 12:59:11	16	31	380	24	1871	2693	44	169.10	19	70.47	CHANGED	cshhpLccshctlc+cpcplEpplcc.ctpl....+chtpp.....ts...........KctAhhhLKc++phEpplsphtsphssl-phthslcshpssppshsuMptuscshKsh..ppphcl-clcclM--hp-ph-htcpIpEslucshs.....sshDE--lptEL-pLtpE.h.pp...................sspLPssPossh	.......................................pLcpshc..pLp+p...t...p.........pl..cpp.cp....p..tpl.........+ch..h.pp......sp..............................pptA.hh....h.h+pthp....h.c.pp.hpphh..........stts.p....l.ct.hthplp.................st.ps...........ppps...hpu.hpt....uscs....hc.ph...pp..p.h..s......l.p..........c......lpplh..c-h.p.c...p..h.ph....h....s............l..p-....h..l..ss...s....h.s...............sp.h-.....E........-...E....l......-...t...E..l.p......p..l.h..pE...ht.p.................................t.ph.s.ths....h.........................................................................	1	636	1020	1514
+259	PF03380	DUF282		Caenorhabditis protein of unknown function, DUF282	Mifsud W	anon	Pfam-B_2840 (release 6.6)	Family	\N	22.80	21.80	22.80	21.80	20.30	18.00	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.08	0.72	-4.21	29	67	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	7	0	65	80	0	37.50	43	23.36	CHANGED	PCosCsK.IYDssCQGhGlPShtsaCssAu-VslsYolGs	.......sCssCsp.lY-s..sCpGhGlPshhsaCsTAuElslpYolG......	0	23	24	65
+260	PF03368	Dicer_dimer	DUF283; dsRNA_bind;	Dicer dimerisation domain	Bateman A, Mistry J, Eberhardt R	anon	Bateman A	Domain	This domain is found in members of the Dicer protein family which function in RNA interference, an evolutionarily conserved mechanism for gene silencing using double-stranded RNA (dsRNA) molecules.  It is essential for the activity of Dicer [1,2]. It is a divergent double stranded RNA-binding domain [3]. The N-terminal alpha helix of this domain is in a different orientation to that found in canonical dsRNA-binding domains. This results in a change of charge distribution at the potential dsRNA-binding surface and in the N- and C-termini of the domain being in close proximity [4]. This domain has weak dsRNA-binding activity. It mediates heterodimerisation of Dicer proteins with their respective protein partners [4].	22.60	22.60	23.10	22.70	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.00	0.72	-4.21	29	491	2009-01-15 18:05:59	2003-04-07 12:59:11	9	58	217	1	308	546	1	94.40	28	5.81	CHANGED	AlshLt+YCupLPpDsasphpPpaphtpts.s...........thhs.plhLP..lsusl+p.lhGp.shpsp+hAKpsAAapACptLachG.LsD+LlPl..hccphtt	.............................................ulshlp+YCupL........P.s..D.t...........a....s.p.h.p..P.paphpphp..s.............................................thhs.plhLP.....hsuP..l...+p...lhG....shs........spchA+psAAhpACppL+ch...G...tLs.D.pLhPh..hpc...t..........	0	93	165	251
+261	PF03382	DUF285		Mycoplasma protein of unknown function, DUF285	Mifsud W	anon	Pfam-B_2864 (release 6.6)	Family	This region appears distantly related to leucine rich repeats.	25.00	10.00	25.20	10.00	24.70	9.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.06	0.71	-11.96	0.71	-4.54	147	2904	2012-10-02 21:32:02	2003-04-07 12:59:11	9	141	295	0	944	3084	4291	103.50	29	50.46	CHANGED	oshpthF..tss...p.......ph........s.psl.......ssWD.....TSsVTsMssMFtsAp...sF..Nps.I....u........s.W.sTSsV........ssM.stMF....tsAps..............F.NQ...sl....us............WssSsVpsMppMFps...AssF.Nps...l....u..sW..ss.usV.pshp.....tMFtsu..ps...Fsps.l......s.sW	......................................................................................................................................................................................................sl........spa..s......s.S.pV.....s.s..M.pt........M......F..t........s......s.....p..........s.h.........s.ts....l......u................s.W..s.s...S..s...V..............ssM..s..tMF..........ts.s...p.s...................Fsp......sl....us.............................W..s.....s..S..p.V.........s.....s......M.p..tM.Fts............sp.sa...s..ts..........l....s...pW..sh.....pp..h.........t.....h.................................................................................................................	0	393	623	794
+262	PF01060	DUF290	Worm_family_2; 	Transthyretin-like family	Bateman A	anon	[1]	Family	This family called family 2 in [1], has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones.\	     The specific function of this protein is unknown.	24.90	24.90	24.90	25.20	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.84	0.72	-3.97	60	474	2009-01-15 18:05:59	2003-04-07 12:59:11	18	15	21	0	419	374	1	79.90	33	48.62	CHANGED	+G+LhCsscP..spslp.V+La-c-.p........s.DchLspspT..cssGpFplpGspsEl....os.........I-P..hlpIaHcCsstsh.......Cp.+chplpIP	.................pGpLhCs.spP.....ss...slp.V+La-cD.p..........................s.D..-lls.p.shT....cssGpFplpG.s..p.sEh.......ss..................I-P....hlpIaHcCsstsh................Cp.+phph.lP...............................	0	150	203	419
+263	PF03478	DUF295		Protein of unknown function (DUF295)	Bateman A	anon	Pfam-B_790 (release 7.0)	Family	This family of proteins are found in plants.  The function of the proteins is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.81	0.72	-4.60	168	1123	2009-09-11 23:18:59	2003-04-07 12:59:11	13	33	21	0	656	979	2	57.40	22	14.95	CHANGED	hhclp..sl....Gc.cslFl.up.spshsss..s...pp...............u.lc.sNslY.....Fs....cs.............................shsl..asl	................hhclp..sL....G.s.csl.....Fl....Gp..s......p.uhs.hs....u.....pp......hs.......u..lc..ssslY...Fh.....cs......................................h....................................................	0	78	186	369
+264	PF03556	Cullin_binding	DUF298;	Cullin binding	Finn RD, Mistry J, Wood V, Eberhardt R	anon	Pfam-B_3021 (release 7.0)	Family	This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation [1-3]. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices [1,2].	27.90	27.90	28.80	28.30	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.92	0.71	-3.95	46	733	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	292	14	456	685	5	115.20	37	44.82	CHANGED	lpcl+pplsplcp.....cL..........ptDspt............F+clYcaoFsaup...cps.....Q+sLsl-hAlshWpLlh..........................ssp.h..............shlctWhcFL.ppp...............pc+u....................Is+DoWshhLpFspph...p.tshosYD.--uAWPsllD-FVEahc	................................................................................pclpspl.spLcppL......................p...-.ssp...........F+chYpasFsau+.....pts.......Q+uL..cl-hAlshWpLlL............................stp..a..........shlshWhpFL.ppp...........................ph+s...........................Is+DpWs.lL-Fsppl.......s..s-hSNYD..-...-...........G.A.WPsLlD-FVEah..............................	0	137	223	342
+265	PF03619	Solute_trans_a	DUF300;	Organic solute transporter Ostalpha	Finn RD, Eberhardt R	anon	Pfam-B_3382 (release 7.0)	Family	This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters [1]. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death [2].	20.70	20.70	20.80	21.10	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.75	0.70	-5.08	55	925	2009-01-15 18:05:59	2003-04-07 12:59:11	11	17	295	0	664	890	27	242.80	29	59.14	CHANGED	sphshh..luuhhslhAhhlShatIhpHLhpYppPppQRhllR.........ILhMVPlYAlsSaluLlh.ptu.........hah-slR-sYEAFlIYsFhsLLhsaLGG....Ep....slhthhp.t+.shp........ashPl.................t.hh.cs.............................hhs.pahphsKtGlLQY...........................sllKPlhsllsllhphhGhY.tpuphshstuahalsllhNhSlolALYsLslFYhshcc..-LpPacPlhKFLslKsllFhSFWQGlllulLsth..Gllpsttthtt..........plusulQshLlClEMhhhAlsHhaAFshpsY	.................................................................h.....hhush.hshhshhlohh.lh...HhhtYp...p...P......................Q.+..h..ll...R.........Ilhh.....lPlY.uh..Salu..Lhh..pts.............hahsslR-sYE..Aa.slY...sFhtLhhp.alGu..............cp...........sl.ht...hp...sc..hp................psh.sh....................................hhh...h....s...............................................................................................hhhs.....thht.......hhKhu.slQa...........................s.ll+Plh..sll..s..llhph.h...G...hY..p.........-...up......h......s....hp.t..ua...halsllhNlS..........h..sh.AL....YsLhlFa.hsh..+c.............Lp...s....h.p.P..l.hKFl.s..lK.h..l.lF..h...........oaW..Qu.hhl.u.lL.th.....Gh....l.sh...t................p..lssulps.h.llClEMhhhulhthauFshpsY.............................................	2	236	372	538
+266	PF03703	bPH_2	DUF304;	Bacterial PH domain	Yeats C, Bateman A	anon	Yeats C	Domain	Domain found in uncharacterised family of membrane proteins. 1-3 copies found in each protein, with each copy flanked by transmembrane helices. Members of this family have a PH domain like structure [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.37	0.72	-3.96	219	4794	2012-10-04 00:02:24	2003-04-07 12:59:11	9	20	1523	0	1147	3777	643	80.00	18	42.58	CHANGED	h+sht..apl..osc+.ltlpt.Ghhs..+cppplshsclpslph.p..l.RhhGh.uclslphssss....................plphhslspsccltphl	..........................h.hp...atl....pscp..lh..lpp..G.l.ht.......+c..p..thlshpR.lQslsh..pp.u.hltRhhGl..sslplpouuss...................................h.lsh.lsh.ppspplht..................................................	0	385	845	1038
+267	PF03713	DUF305		Domain of unknown function (DUF305)	Yeats C, Bateman A	anon	Yeats C	Domain	Domain found in small family of bacterial secreted proteins with no known function. Also found in Paramecium bursaria chlorella virus 1.  This domain is short and found in one or two copies. The domain has a conserved HH motif that may be functionally important.  This domain belongs to the ferritin superfamily. It contains two sequence similar repeats each of which is composed of two alpha helices.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.20	0.71	-4.39	86	1321	2012-10-01 21:25:29	2003-04-07 12:59:11	8	8	713	3	551	1532	484	122.80	24	68.56	CHANGED	DhsFhppMlsHHpQAlcMuphsh...p+upssplcsLAppIhsuQpsEIspMpuWLptWstssssss................................................t.ttttttssMs.......GMhostphspLpsupG.............sshDphFLphMIsHHpGAlsMApstl.........p...pu.pssplp.plApsIlssQpsEIspMpphL	............................................................................a...h..ap..u.l.hs................t....th.ths.tl..tpt.pht.h..hh.................................................................................t....tth...............th..hpt........h.t...h.t.t.h..t........................sphDhhFhph.M.l.s.H.HpGAl.t..MA.p.h.t.l............p......u..ps.s.p...h.cplApp...llpsQptEIttMpth.............................................................................................................................	0	158	358	476
+268	PF03754	DUF313		Domain of unknown function (DUF313) 	Finn RD	anon	Pfam-B_2540 (release 7.0)	Family	Family of proteins from Arabidopsis thaliana with uncharacterised function.	24.40	24.40	24.40	24.50	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.27	0.71	-4.16	14	95	2012-10-02 12:51:43	2003-04-07 12:59:11	8	4	11	0	70	93	0	102.50	29	36.72	CHANGED	pphPcWLlpsM+chpG...pcP.+LIhcKs.LhpTDl.ssspuRL...uhPhspllpsDFLT.-EpRhl.......................c-ct.sscshGlsshLV-sctpcaslpLK+WsM......pushpYsLspGWNsVVcs	.................................P..lhphhpphpu...p-s..+hlhpKp.LhtoDl.ssspsRL....hPhp.plhp.p..-......FLTppEpchl..................................p.p.pt...t..pcthGltshlls........ph....pph.tlph++WpM........pts..YsL..psWp.pllp.s............	0	21	40	47
+269	PF03761	DUF316		Domain of unknown function (DUF316) 	Finn RD, Bateman A, Pollington J	anon	Pfam-B_2972 (release 7.0)	Family	This family of proteins with unknown function are from Caenorhabditis elegans. The protein has GO references indicating the protein is a positive regulator of growth rate and is also involved in nematode larval development.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.91	0.70	-5.06	9	172	2012-10-02 13:45:52	2003-04-07 12:59:11	10	6	7	0	171	227	0	232.30	16	67.50	CHANGED	hlhlhhhllhhshssspcLo.cENppRhpoCGpchls.ps...........ssshhsptpppsWhlhsthpstsptphh........suohISsRHllTsuplhhsscptW.h.....cpssspssCsus..pL.VP.-lLcclcl......sphpsppshptpls+AhlhshC......h..t.phttsPMllElcts.....sssshsCLuscspp.hccs-hlcsYGl......psstchhcpphslsss........s.hphsosthhsptctuGsLlpphss+hsllGhtussshtspt......sthFaslsp.hpppICchsGIC	............................................h.........................tpLs.pENt.h.tpCG.......................................................................................................ts..Whh..h...h..t...................................sushISsRHllsss..p...hh..h.......p.....t........p........t.....h....t......................t..h....t.p.Ct..t.t......h..........ls.p.p..h.h.p.p.h.h....................t................h....hp.hhhhthC......................................t....h....ll...Ehpps........................h.....t....sCl.s.......p.......p....................tp......h..p.hath......................tt...h......t...hph.t.h......................t.h.ht......t.t.....s......tp....Gus.hlt........h..s.sc...p..l.lGl...hs.tss..t..........................hah..p.hth.htpplCphsGlC....................................................................................................................................................................................................	0	23	38	171
+270	PF03777	DUF320		Small secreted domain (DUF320)  	Yeats C	anon	Yeats C	Domain	Small domain found in a family of secreted streptomyces proteins. It occurs singly or as a pair. Many of the domains have two cysteines that may form a disulphide bridge.	20.20	20.20	22.10	20.50	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-8.88	0.72	-4.20	17	305	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	44	0	123	327	0	60.30	52	54.99	CHANGED	usuusAtu..susApGuAssSPGVlSGNsVQlPVHVPVNVCGNTVsVlGlLNPAhGNtCsNs	.................s..uuhAtu..suuA.pG.....s.As.u..SPG....VlSG..NsVQlPVcVPVNVCGNoVsVlGlLNPAaGNsCsN..............	0	47	99	123
+271	PF03860	DUF326		Domain of Unknown Function (DUF326) 	Yeats C	anon	Yeats C	Repeat	This family is a small cysteine-rich repeat. The cysteines mostly follow a C-X(2)-C-X(3)-C-X(2)-C-X(3) pattern,  though they often appear at other positions in the repeat as well.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.56	0.73	-7.95	0.73	-3.88	20	528	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	287	12	108	324	6	22.60	39	31.24	CHANGED	spchpppCt....chCpcCuctCppps	.....pchCphCA....chCppCA-tCtch.....	0	38	77	102
+272	PF03935	SKN1	DUF338; 	Beta-glucan synthesis-associated protein (SKN1)	Finn RD, Moxon SJ	anon	DOMO_DM01831	Family	This family consists of the beta-glucan synthesis-associated proteins KRE6 and SKN1. Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-glucan, and chitin. It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1. This is followed by maturation steps at the cell surface and by coupling to other cell wall macromolecules [1]. 	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.72	0.70	-6.35	26	512	2012-10-02 19:29:29	2003-04-07 12:59:11	10	17	128	0	415	1147	311	346.50	30	68.38	CHANGED	asLhh--cEsDDaLHNPDP..csph-+p+hhh-hchhs+RuhsslhGllhLhluhlslFlshPlLTao...sssp+tss..............pshphloshpYPhLuuIR.ouLlDPDTPpsAho+pup.c.GppWpLVFSDEFNs-GRTFY-GDDQFaTAsDlHYsATpDLEWYDPDAl.TTtNGTLplRhDAFpNHsLhYRSGMlQSWNKhCFT.tGhlElSAsLPshGsluGLWPGlWTMGNLGRPGYhAoTEGlWPYSY.-uCDsGITPNQSSsDG.....................ISYLPGQRLssCTC.sGEDHPsP.....G.sGRGAPEIDllEuphssshs.........lGsASQShQlAPFDIWYhPDY...salplYsposTshNoYsGGPFQQAlSulTsLNssWY..tt..su.ttFQpYuaEYh...N-ccsG.......YlsWaVGcpsTaTlhupALtPNG..NIutRhIScEPMSlIhNLGlSsNWAhIDWtpLh..FPssMpIDYVRlYQspsphs....VsCDPs-YPTh-YIppH.ssYpNsNLTsW....ppuGY..oaPKNpLhss.C	.......................................................................................................h....................................................................................................................................................................h...lD..pT...P......th.........h.......s......p.......s.........tth.L..............lhSDE..F.....p........................s.....R......o.......F..........h....G.....-..D.........h.a...p...u......c.....h.........................s.s...t..s....h.E.....h.....Y.............s............p...h...h.......s.T...............t................s.....G.......h............h..................h........p..................t..........................................................................t................t..................h..........................a.......puu................M................l...p............o.....W................N.................p.................hC..ap.....t........G..hl..Eh.............p.........hpL.........P..............s...................................s..t.......h...G....................h......WPuhW.h.G..N..Lu....Rs.h.a..uospt..h......WPaoY.ptC-.....shh...s.......................................................................+lstCss.....s....t.........t.s............uRuAPEIDhhEuth..................................hSpS..hQhu...P.............................................................................s.....p..h........s......................h........p..........p........uhSs.........ht.th.a..............................a.hathE......ah......................p.u..........lpW.h.tt...p.......a...p.....h..s..........t.u.....h......t.....s..ss..........p........s..........+.......h...........E.......P.......M...................hlhN..huh..S...sa...............t.....................................p...............l................hP....h.lDalRlYQ...........s...t...p.......lsCDP.s..a.P..T.p.aIt.t..a...t.Y..s..p.........................................................................................................................	0	198	310	400
+273	PF03990	DUF348		Domain of unknown function (DUF348)     	Yeats C	anon	Yeats C	Domain	This domain normally occurs as tandem repeats; however it is found as a single copy in the S. cerevisiae DNA-binding nuclear protein YCR593 (Swiss:P25357).  This protein is involved in sporulation part of the  SET3C complex, which is required to repress early/middle sporulation genes during meiosis ([2]). The bacterial proteins are likely to be involved in a cell wall function as they are found in conjunction  with the Pfam:PF07501 domain, which is involved in various cell surface processes.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.69	0.72	-4.38	167	1769	2009-01-15 18:05:59	2003-04-07 12:59:11	9	27	678	0	449	1328	21	42.70	28	24.80	CHANGED	sVslsl.-Gcpp.plh...TtusTVs-lL....pptsls.l........s.ppDplsPuhss	............Vslsl.sGcpp.plh...Tss.sTVs-hL......pptsls.l........s.spDtVsPuhs..................	0	167	335	408
+274	PF03993	DUF349		Domain of Unknown Function (DUF349)	Yeats C	anon	Yeats C	Domain	This domain is found singly or as up to five tandem repeats in a small set of  bacterial proteins. There are two or three alpha-helices, and possibly a beta-strand.	21.40	21.40	21.60	21.40	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.62	0.72	-3.82	128	2482	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	722	0	644	2200	886	77.50	24	48.45	CHANGED	-sLWpR.FcsApcta.cp+pthhpphcpppppNhptKctLlpcA.Eplts.ssc.....hpsstpph+pl.ccW+slG....plP.Rcps	.................................-tLWp+.Fpsspstahct+pt.th.......pptcppppp.shptKc....tLlpc....A.c.tLss..ssc................hpsstpph+pL.h....c....cW+.s.lG....tls.+c..............................	0	229	508	614
+275	PF04008	Adenosine_kin	DUF355; 	Adenosine specific kinase	Bateman A, Lott S, Mistry J	anon	COG1839	Family	The structure of a member of this family from the hyperthermophilic archaeon Pyrobaculum aerophilum contains a modified histidine residue which is interpreted as stable phosphorylation [1]. In vitro binding studies confirmed that adenosine and AMP but not ADP or ATP bind to the protein [1].	25.00	25.00	34.70	34.70	20.10	17.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.85	0.71	-4.72	34	283	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	277	26	124	228	14	154.30	59	95.54	CHANGED	Vsl-hP-.ssNlIlGQoHF.IKTVEDLaEsLlsoVPul+FGlAFsEASG.pLlRhsGND-cLhclAhcNAhtIuAGHsFllhl+su.aPINVLNslKsVsEVspIFsATANPlpVIVAcTc.pGRGllGVlDGhsPhGVEs-cDhpcR+chLRc.IGYKh	.....Vsl-pP-.ssNlIlGQoHF.IKTVEDLaEALVsssPul+FGlAFCEASG.RLVRaoGNDt-LlcLAscNAhsIGAGHsFlIaL+cG.aPI.NVLNslKsVPEVCpIaCATANPlpVlVApTs.pGRGllGVVDGhoPLGVEo-cDltpR+-LLRp.I.GYK.........................	0	45	78	104
+276	PF04013	Methyltrn_RNA_2	DUF358;	Putative SAM-dependent RNA methyltransferase	Bateman A, Eberhardt R	anon	COG1901	Family	This family is likely to be an S-adenosyl-L-methionine (SAM)-dependent RNA methyltransferase [1].	20.50	20.50	20.60	20.50	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.12	0.71	-4.77	7	215	2012-10-01 22:53:19	2003-04-07 12:59:11	7	2	203	7	89	165	66	185.90	39	94.48	CHANGED	MR.FllhuscAhTssshsLcDLPGsuGRlDllCRshssAhalSHuhRcsVplallLhGsPsPP+olphcusclc...hpPDEtslAhhlp+ALpuht....tttcph.pspPGlaVsphuFEsllptlhc..hslhhLcEcGtDIpssphs....NPsFllGDHlshsccphphL-ch...sh+lSlGPhsLhssHslsllpthLD+hth	...................................MRsFll+A+sAsTsup.h..Lc-lsG.pu+h-lLs+shhsulFhupuhRcDVhlaLVLpus.....D.s.+TIphcus.-lpp..sh.-pt.lAhll+th.tust......hsc-ph+.spPGl..pVcs.hoFEtLlt-lucc..t.......pLYhhcccGcsIR-hchss......NPsFlLoDHIshsccsts.lc+lG..scKI.SLGPchLaASpClsllHNElDpt......................	0	20	51	70
+277	PF04020	DUF360		Membrane protein of unknown function	Bateman A	anon	COG1950	Family	These proteins a predicted transmembrane proteins with probably four transmembrane spans. The function of these bacterial proteins is unknown. The sequences do not appear to contain any conserved polar residues that could form an active site.	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.72	0.72	-3.70	107	1355	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1191	0	468	1052	200	109.60	31	76.40	CHANGED	h...hphllphll.sAluLhlsuhlh..s........G...lplsu.....................hhsslluAlllGllNsll+PlLh.llolPlhl....lThG........LFsh.........VINAlhlhLs.uhll.s....G.....Fpl.pu.Fh.sAlluulllollshll	..............hphllphll....sulslhlluh..lh.s.........G.....lplsu.....................hhsAlluAlllullNsll+PlLh..ll....oLPlsl....lTL....G........LFt.h.........VlNAl.hlhls.uhlls...............uFpl....su.....Fh.sAlluulllSllshll..........	1	163	349	428
+278	PF04037	DUF382		Domain of unknown function (DUF382) 	Wood V, Finn RD, Moxon SJ, Sammut SJ	anon	Pfam-B_10232 (release 7.3);	Family	This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalysed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyse pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site [1].	21.90	21.90	22.30	24.60	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.57	0.71	-4.32	24	357	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	295	0	253	336	8	123.00	59	20.84	CHANGED	Vp+P-lVEhaDssupDPhhLltlKup+NsVPVPpHWspKRcYLpuKRGlEK.PFpLPcaIcpTGIschRssl.-c....-scpoLKQKpRERVpPKhG+lDIDYp+L+DAFF+aQo..KPc.LopaGDl......YYEGKEh	........Vt+P-VVEhaDsoApDP+LLVpLKuhRNoVPVPpHWshKRcYLp..............GKRG.IEKPPFpLPcFIpcTGItEMRp.........Al.EK............--ppoLKpK.RE+VpPKMGKlDIDYQKLHDAFFKaQT..KPc.LThaGDl......YYEGKE...........................	0	88	143	209
+279	PF04075	DUF385		Domain of unknown function (DUF385) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of Mycobacterium tuberculosis proteins.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.68	0.71	-4.19	10	1560	2012-10-02 11:35:36	2003-04-07 12:59:11	9	13	225	27	512	1351	399	123.90	24	82.54	CHANGED	s.hh.Rt.sthaRcssG.tlGpph...G.hP.hlLLpTsGR+oGpsR+TPL..htsccssp..ahlVAShGGss++PsWYhNl+AsPcVclplGscphssTA.R.ls..s--+Achathsstshsu.YssYQstTsRp.lP...VhVLps	.....................................................h.............h.t..s....h.u.t...h.............s...h.......s...hhl..LpssGR.KS.GpsRpoP..L.............hh.h..c.c.s.sp.........hhl.Vuo.t...Gu.....p...p....ss....WhpNlp.A.s..P.p...s..pl....p....h.....s.s.....c.....p.....h.s...s...s.A...c.ls..ss.-.+....s.phh..h..h.t.......s...s...h...h...t........s.t.....t..ls...hh..........................................	1	139	367	466
+280	PF04087	DUF389		Domain of unknown function (DUF389) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of hypothetical bacterial proteins with  an undetermined function.	22.60	22.60	22.90	22.70	21.90	22.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.89	0.71	-4.23	127	1004	2009-09-11 12:27:41	2003-04-07 12:59:11	9	4	851	0	318	852	168	140.40	38	35.44	CHANGED	MlIuPLhuPlhuhuhuhshsDhpLhp+ulhs.....lhlGhhlulhhuhlhu.hlhs.........l..p..hssElhuR..opPs....lhDlhlAlsuGsAGshuh.spp............h.usulsGVAIAsALlPPlsssGluluhu...................................p.hshuhGuhhLahsNl.luIslu	....................MLISPLMuPIlGluhululhDhcLl++Shps.....Lhltlhlullsuslah.hlsP......................ls....ssuElluR.........TsPs........lhDllIAlsuGlAGhluhppc.........ptssslsGVAIAsALhPPlsssGhulAtu....................................................s.hphhhGuhhLahlNsshIsls......................................	2	94	200	279
+281	PF04155	Ground-like	DUF398; 	Ground-like domain	Bateman A, Moxon SJ, Burglin TR	anon	Pfam-B_3296 (release 7.3)	Domain	This family consists of the ground-like domain and is specific to C.elegans. It has been proposed that the ground-like domain containing proteins may bind and modulate the activity of Patched-like membrane molecules, reminiscent of the modulating activities of neuropeptides [1].  	35.40	35.40	35.70	36.60	31.30	35.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.44	0.72	-3.67	41	278	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	8	0	267	225	0	77.80	24	27.83	CHANGED	spsspCsstcLcplhpcshpt.........pshstspctlppsspppass..papVICupscFuasspss..paCph.ppsshsChsap	.................................ps.pCsstcLcplhppshp...........................sssppupctlppsscpphss...pFsVICupscFuahspss..taCph.ppsshsChsat...........	0	89	124	267
+282	PF04241	DUF423		Protein of unknown function (DUF423)	Kerrison ND, Finn RD, Pollington J	anon	COG2363	Family	This family of proteins with unknown function is a possible integral membrane protein from Caenorhabditis elegans. This family of proteins has GO references indicating the protein is involved in nematode larval development and is a positive regulator of growth rate.	25.00	25.00	25.90	25.60	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.16	0.72	-4.06	133	2074	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	1956	0	507	1237	289	88.50	40	68.64	CHANGED	ulGAFuAH...uL......c..sh.lsschhph.a.pTuspYphhHulALl.slu....hhht.......ssphhthuuhhhhhGllLFSGSLYhluLouh.....+hlGh.lTPlGGl	........................hLGAFGAH...sL..................p.....pp..lust.....t.h.sh...h.pTGlpYQhaHuLAlLslu....lhhtp...........huhhh.thu..uhhhhhGhlLFSGSLYsLuLotl.........+hhuh.lTPlGGl.............................	0	160	296	414
+284	PF04255	DUF433		Protein of unknown function (DUF433)	Kerrison ND	anon	COG2442	Family	\N	21.40	21.40	21.40	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.31	0.72	-4.55	140	905	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	315	2	319	945	159	53.80	31	47.88	CHANGED	Ish...sPslhuG+PsI+GTRlsVpsllphl.usGhoh-EILps..YPp.LstcDlhAALtYA	................IshsPphhtGpPsIcGpRlsV.tsllphl.ssGh.o.h--llpc..aPt.LshcslhsALtYh............	0	106	251	305
+285	PF01862	PvlArgDC	DUF44;	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC)	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	Methanococcus jannaschii contains homologues of most genes required for spermidine polyamine biosynthesis. Yet genomes from neither this organism nor any other euryarchaeon have orthologues of the pyridoxal 5'-phosphate- dependent ornithine or arginine decarboxylase genes, required to produce putrescine. Instead,these organisms have a new class of arginine decarboxylase (PvlArgDC) formed by the self-cleavage of a proenzyme into a 5-kDa subunit and a 12-kDa subunit that contains a reactive pyruvoyl group. Although this extremely thermostable enzyme has no significant sequence similarity to previously characterised proteins, conserved active site residues are similar to those of the pyruvoyl-dependent histidine decarboxylase enzyme, and its subunits form a similar (alpha-beta)(3) complex. Homologues of PvlArgDC are found in several bacterial genomes, including those of Chlamydia spp., which have no agmatine ureohydrolase enzyme to convert agmatine (decarboxylated arginine) into putrescine. In these intracellular pathogens, PvlArgDC may function analogously to pyruvoyl-dependent histidine decarboxylase; the cells are proposed to import arginine and export agmatine, increasing the pH and affecting the host cell's metabolism. Phylogenetic analysis of Pvl- ArgDC proteins suggests that this gene has been recruited from the euryarchaeal polyamine biosynthetic pathway to function as a degradative enzyme in bacteria [1].	21.00	21.00	21.70	23.30	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.93	0.71	-4.64	33	246	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	222	50	144	240	51	163.40	30	93.55	CHANGED	hlP++hFhTpGsGcpc.spLs.......uF-hALt-AGItphNLVpVSSIlPPps..chlscppuhthLsPGpllasVhu+..tsoscsschIuAulGhAhsp........pspaGhlsEacuhsppcc.utchucchApphhpsp....................utclhcsttlsppscl..p.ucasoslAAsValh	.........hPpphFhTtGsGcuc..stLs........uF-hALhcAsItshNLVplSSllPsps...pllshpps...c.hl..Gpll.slhAp..ssos.csschIuAulGluhsp.c.......ppthGhlsEapuhsp.s.pc..stchscchspthhppp....................shclt..-hphhspptpl..p.sthsTslussshh...............................................	0	48	93	125
+286	PF04332	DUF475		Protein of unknown function (DUF475)	Kerrison ND	anon	COG2899	Family	Predicted to be an integral membrane protein with multiple membrane spans.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.00	0.70	-4.84	7	451	2012-10-03 02:02:08	2003-04-07 12:59:11	10	2	409	0	130	677	107	296.80	50	83.95	CHANGED	FDNAllNAuIL+pMS.hWQKhFLTlGILIAVFGMRLlFPllIVuhoAtlsPlcshcLALps...........sspYpcllpsAHPpIAAFGGhFLLMlFLsFhhc-cc.h+WLphlE+PLs+lG+lshlssllshlhLllhuthhstsuc.ht........tVLhAGLhGllsYhlVsulsphFc.....................ss....shthuG+AGlAhFLYLElLDASFSFDGVIGAFAITsD.VlIALGLG.IGAMFVRSlTlYLV+pGTL-cYVYLEHGAHaAIGsLAlIhLlolp..aclsEllTGLlGlsaIuhuhhtSlhtNRpp	.......................................................................................................................................FDNAlVNAslL+cMoshWQ+hFLTlGILIAVFGMRLVFPllIVulsA..tlsPlcAlcLAlps...........PspYppllscuHstIAAFGGhF...LL..MlFLsFhF-ccc.l+WlphlE..p...h.....u......+.lu......p......l......s..slplhlAll.....hll.lhuthlst.spp..t...........olllAGl.hG....l.lT...a.lsVpu..luph.h-st............................................t.ts.......shsss..s....+..u.G...h..u.....t.F....L....Y....L...EV...LDAS...FSFDGVIGAFAITssl..llIAlGLG.IGAMaVRSlT..laLVc.+GTLscYlYLEHGAH...Y..AIG..s....L.A.l..Ihll.shh........h....cl..P.E..l.l.T.G.L..l..Gl.s...h.Iuhuhh....oSlphN+t.t............................................................	2	35	82	106
+287	PF04720	DUF506		Protein of unknown function (DUF506) 	Waterfield DI, Finn RD	anon	Pfam-B_4111 (release 7.5)	Family	Family of uncharacterised plant proteins.	25.00	25.00	26.30	25.50	24.80	19.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.48	0.70	-4.71	10	299	2012-10-11 20:44:42	2003-04-07 12:59:11	7	7	31	0	209	295	2	182.20	30	59.25	CHANGED	Ls-lVpuFlE-sspt.pp.p.........pusus-uSs--s-psssu.p.tcsp-clcpLL.spshc-pp...l.scltpsscps.t..................stosh+cclsshLRp.hGYDAulCKS+WcpSsc....lPAG-YEYlDVlhsss.....t.RlllDlDFpSEFEIARsTcpYpplLppLPtVFVGps-RL+pll+llCcAAKpShKc+GlalPPWR+scYMQuKWhGsYcR	................................................................................................................................................................................................................h.....p....p.t......hh...t......pt.t.......h.tph.thhpt...........................ttsshhphlsptLpt...hGasuu.l.CcS.+W..p....p..o.sp........hP.u.G.................caEYlD...V.l.h...........t...s..p................Rlll-lcFRupF..ElA.R..soppYpt.ll.p.tLP....t.lFVGps-+LpplVplhspAu+pSh+........ppuhplPPWR+.pYMpuKWhus..R.........................	0	62	148	177
+289	PF04784	DUF547		Protein of unknown function, DUF547	Mifsud W	anon	Pfam-B_3926 (release 7.5)	Family	Family of uncharacterised proteins from C. elegans and A. thaliana. 	20.20	20.20	20.30	20.20	20.00	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.49	0.71	-4.22	101	769	2009-01-15 18:05:59	2003-04-07 12:59:11	9	30	360	0	388	743	150	124.20	29	25.55	CHANGED	pls.....pph.scpEpLAFWINlYNAhslchlLpph...........lp.Slp...h.................s.a.pc.................................thhsluGpthoLssIE+tILRtp...................................hs-.PRlHFAlsCuohuCPsLc..saoupplcppL-puscc.Fl	...................................................t.ls..pph.scp-plAFWINlYNAhsh.............+sh.Lphh......lsts.tch...h........................shh.pc.................................sshsl....u.......G...p..ph.ohssIEptILRs........................................................................hs-.Ph.l+FALsCuuhos.Pslc....sYoupp...lcppLcpAtccal..................................................	0	122	263	342
+290	PF04484	DUF566		Family of unknown function (DUF566) 	Finn RD	anon	Pfam-B_3992 (release 7.5)	Family	Family of related proteins that is plant specific.	25.00	25.00	27.60	27.40	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.95	0.70	-4.91	18	186	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	20	0	122	170	0	289.00	27	56.20	CHANGED	t.....................phuosssstspssspssutcthtst...............s.ss+spshsssupt.sossspsssSpSs........................s.hspthhuPspstss.....s..h....................sPs+tppsss..........................tsssssslh...shhsshh.+uKpstschE.csHpLRLLt..NRhLQWRFsNA+s-sshhspphsAE.ptLassWhplspLps.Vsh+RltlQhh+QclKLhtlLptQhsaL-cWstlEpcHuoSLsuAhcuLcAuTLRLPlssGApuDhpulKpAlsSAVDVMpshuSSlhpLLu.KV-thsslloELuplsspEphhLp	.........................................................................................................................................................................................................................................................................................................................ttsts......................................................tsp.pth.s.pssp..ss..ss.p...h.s.s......................................................t..ss.h.s.pthh.oPsp.....tt.ss.........ss..st...h...........................sPsp.ptsss....................................................................................t.stssslh........shhs.shp..+s+t..stsp....hE.-sHpLRlLt..NRhLQWRFs.....NA+A-sshtspp.hsAE.ppLassWhphspLpcsVshKRhplQhh+pchK...Lhsl..LpsQ.......hs........hL-pWu.lEpcausuLssshcuLpAuoLRLPlssGA..........psD.hts.lppulsuAlclMpshtusltt.hhs.+spthsslls-LutlstpEphhh.........................	0	19	72	95
+291	PF04526	DUF568		Protein of unknown function (DUF568)	Waterfield DI, Finn RD	anon	Pfam-B_4977 (release 7.5)	Family	Family of uncharacterised plant proteins.	25.00	25.00	25.80	25.00	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.40	0.72	-3.71	19	208	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	26	0	118	209	0	101.80	32	29.55	CHANGED	MsGoQullAap...sus..GshpshT.slsSYss..Ltpus...LuFsVspluAp...ss............uchtIFATlpLP...sNssslNpVWQsGshst.GsshshHshSGsNlpShusLDl	.......................MsGoQALlAap.......sss...Guht..lh..Ths..lsuhss.....l..ptus......l.uasls.s.luAph..ss.............uphpIaATlpLs.....sstoplNpVWQsGshs...ussPthHs.h..su.sNlpShuslDh..................................	0	14	75	98
+292	PF04502	DUF572		Family of unknown function (DUF572) 	Finn RD	anon	Pfam-B_3967 (release 7.5)	Family	Family of eukaryotic proteins with undetermined function.	24.00	24.00	24.00	24.00	23.40	23.80	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.22	0.70	-5.21	18	653	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	303	0	474	629	5	286.40	27	91.35	CHANGED	MuERKslNKYYPPDFD.............PuKlP+h+psK....spQhsVRhMhPFNhRCsoCspY...IhcGpKFNARKEcVtsE.YLGl.IaRFYhKCspChsEIshKTDPcNsDYshEsGAoR.sapsc..........cttp-phcphcccccp........................EptsssMctLEpRTtDu+pEh-shtsL-EL+chppR..csslshsuhLcph..tcpcccptpcp-E-Dpphhcpltht......pppcp+Rhhs-..........p-tpc-.................t.sstspsspsutspsoshhspsstppspssstpphptss...................t.+sthssllhtKKptssssppst...................................tpsttpsspsssssuLstLst....hssS--s	...................................................uERKshsKYYPPDaD....................................................sph...sht.cp.s+..................pt...hh.l.R..h.hPFsh.hCssCs..pa..........IhpGh+FNAcKcpVss...........Yh.u.h.Ia+FhhKCs.tCss.pIph+TDPcN....s....D....Yshpp.G.ApR..shc.........................................ttp...ppp.h...t....t..h.....p..c..c...c....cc.........................c.ttscsMt.tLE....pcttD..pc.pthc.........h.h.ttLp..cl.pp.hp.pc......pssh.s...hs...p...h...Lcph.............hcp.pc..c....t......h.pp.....pp...c.pcp..t..h...hpph..h......................pp.tp..p.chht................................tp................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	176	266	389
+293	PF04504	DUF573		Protein of unknown function, DUF573	Mifsud W	anon	Pfam-B_2087 (release 7.5)	Family	\N	29.50	29.50	29.90	29.50	29.40	29.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.20	0.72	-3.72	21	208	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	21	0	126	194	0	93.60	31	25.96	CHANGED	thFQRl.Wo--DElslLQGhlDa.cscpGt..sshp.DhsuFa-hlKppIshcsSKsQhssKlRpLK+Kapsphp+......tsp-.sFspsHDpcsFcLu+hIWGs	...........................t..hpRl.WoccDElhlL......pGhlsa..psppGh.........ssht..Dhssha.-tl+pp.l.p.h.c.h.op.sQLh-KlRRLK+KYpsthp+........tu....tt..shppsH-pphacLu+plWs...............	0	23	58	87
+294	PF04535	DUF588		Domain of unknown function (DUF588)	Bateman A	anon	Pfam-B_1439 (release 7.5)	Domain	This family of plant proteins contains a domain that may have a catalytic activity.  It has a conserved arginine and aspartate that could form an active site. These proteins are predicted to contain 3 or 4 transmembrane helices.	21.10	21.10	22.30	21.40	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.80	0.71	-4.64	84	771	2012-10-03 17:26:12	2003-04-07 12:59:11	7	12	74	0	461	799	0	135.20	22	69.99	CHANGED	ppshphsplsLRlsshshslsuhslMuospps..h...............h.hpspasshsuapahVsusulsssYsllphshshhthhh.......tsh.hhhhhhhhDtlhshLhhuAuuAAuuls.ls......ppGstpht.h....hCpthspF.Cpps.suulshuFluhlh	............................t..hthhslhLRlsshshslsuhslMusspp........................................h.tspa.sshsu...a...pa...hlsusulsssYslhphhhshhthhh................tsthhhhh..h.....hhhD................t.......l..hshLhhuuuuAAsuls..lh..............tpu.t.t.............hC..........t....h..........s..pF..Cpph.ssulshuFhuhh................................................	1	61	279	376
+295	PF01883	DUF59		Domain of unknown function DUF59	Enright A, Ouzounis C, Bateman A, Eberhardt R	anon	Enright A	Family	This family has an alpha/beta topology, with 13 conserved hydrophobic residues at its core and a putative active site containing a highly conserved cysteine [1]. Members of this family are involved in a range of physiological functions. The family includes PaaJ (PhaH) Swiss:O84984 from Pseudomonas putida. PaaJ forms a complex with PaaG (PhaF) Swiss:O84982, PaaI (PhaG) Swiss:O84983 and PaaK (PhaI) Swiss:O84985, which hydroxylates phenylacetic acid to 2-hydroxyphenylacetic acid [2]. It also includes PaaD Swiss:P76080 from Escherichia coli, a member of a multicomponent oxygenase involved in phenylacetyl-CoA hydroxylation [3]. It is found near the N-terminus of the chloroplast scaffold protein HCF101 Swiss:Q8LD16, involved in the assembly of [4Fe-4S] clusters and their transfer to apoproteins [4].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-9.16	0.72	-3.99	74	6019	2012-10-01 19:25:19	2003-04-07 12:59:11	14	30	3431	23	1809	4321	2549	73.70	27	34.66	CHANGED	cpplhsALppltsP.sG.tsllstshlcs....lslps.......spVphslpls.Psps..thpsl+ppscpslt.slsG..sspVpl	......................pplhpsL.c.pVhDP.....E....ls.hslssLGl..l..h..s.........l.p.l.cs...................spl.p......l.....s.hTl..T..s.suCP....hsshltpplppslp..tlst......ps.........................................	0	581	1153	1528
+296	PF04547	Anoctamin	DUF590; 	Calcium-activated chloride channel	Mifsud W	anon	Pfam-B_2735 (release 7.5)	Family	The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes [1].	28.00	28.00	28.60	28.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.64	0.70	-5.84	102	1393	2012-10-02 00:51:22	2003-04-07 12:59:11	7	39	257	0	866	1250	37	444.10	27	58.75	CHANGED	I+sYF.....GEc...luhYFuaLsaYophLlhsAllGlhsalhthh...................................................................................................................t..hp..hsshFulhhslWuolFlEhWKR+.psplshcWshhshp.............p.p..R....spFputhh............................ths.lTs......................c..hhsthc...phh+h.lhshsllhhhlshhhshhluhhh............................hchhltphht...................hph.h.shlssll.hlhl.llshlYpplAphLTchENa+...........opspY-suhhhKhal..............................hpFlssasslFalAFhps........................................h....shpcLphplhhlhlspQlh...p.lhEhllPhlhph.......................................................................................................................hpph..............phppptpppp.......................................................................................................................pt.hhpphcp-h.phpsas..................................shh....s-YhEhhlQFGalsLFusuFPLuslhuLlsNllEl+sDthKhhp...h+RPhsp.+spsIGsW.pllphluhlulloNshllshsp................................tphpshhst...............................................................hlhhllhhE.................alhhhl+all....phhls-h.....Pptl......ptphcRpca	....................................................................................................................l+pYaGp...+luhYFuaLsh..YTthLh.sulhGlhhah.h.shh.....................................................................................................................................p......hslhFul....h.h.sl..W.....u...s..hFlE..h...WK.Rp.ps........tls.hpWshhshp.............t.cp.R...spaps.hh..............................................................hhs.hst.........................................................p.....c...h.hs.hp...ch..hhh...hhsh.shh.hhhl..hh..h......hshhhshhh......................................................hc....hhhhthht..........................................ph.hhshhsshl....hlhl........l.h..s............lY.......p.p.l.A.h.hLTph....E..+................Tp.s...pa-pphhh...Khal.......................................hpFlN...as.shFY..l.A.Fhht........................................................................h...........shhc..Lp.plhhl.h......l.spQ.hh...s.shhE...hh.hPh.h..h..ph.........................................................................................................................................................................................h.pph.........................hppt.tt.t..................................................................................................................................................................htphc.-h...pL.ts.ht...............................................shh.-..YhEh.......h....lQFGal.olF....ss.uaPL.As.lh...ALlN.NllElRhD......AhKh.sp..............h+R..........P............h................s..t.....+......s...p.....s.........I............G.........h......W...t.hhphluhlullsN.s..hl...luhsp.....................................................................tphpthhst....................................................................................................................................................h.tstlhhlllhE.................pl.hhhlphhlthhlPch....Pt.l.t.pht+..............................................................................................................................................................	0	302	410	651
+297	PF04576	Zein-binding	DUF593;	Zein-binding	Mifsud W, Eberhardt R	anon	Pfam-B_2802 (release 7.5)	Family	This domain binds to zein proteins, Pfam:PF01559 [1]. Zein proteins are seed storage proteins.	21.00	21.00	21.20	22.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.14	0.72	-3.86	26	261	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	22	0	164	232	0	91.70	43	16.67	CHANGED	lptL+ctlctp+cshpsLhpELEcERsAuAsAAsEAMuMIhRLQcEKAslpMEApQapRhhEEptpaDpEtlphLpcllhcREc-hptLctcl-	......................h.ttL+ctlptp+cshpsLhtELEcERsAuAsAAsEA.MAMIhRLQcEKAuhpMEApQapRhhEEptpaDp-slptLp-llhcREp-hppLctcl.....................	0	23	93	133
+298	PF04642	DUF601		Protein of unknown function, DUF601	Mifsud W	anon	Pfam-B_5475 (release 7.5)	Family	This family represents a conserved region found in several uncharacterised plant proteins.	21.70	21.70	24.00	23.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.95	0.70	-5.06	4	14	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	3	0	8	16	0	185.00	38	47.09	CHANGED	MuGTLEDSKLRAh-KAKp.ps-scutoRQcs...Ss.AuKsscsPTS-utossKsssuKDssKRtADKKRKpsEcDupSPsRSSRsRpEEKssu.sppKtcsKcu.sQsLV..VLSSp.SEscpSphRoo.PlPAPPhsFADhhRTLVtPGusIsPhcEhKtsN+ENYLRFAtKLGchl.EFN.sFhSHEDQL.DKDpEIESFKpsE-ENA+hV-RANpVLsRM+sAEs+VQpLElsNhDLsAKLcuGKNAY.ssI-pEspuRA-LhsCEEKh+KLEEtQAshlssARpEERRKVRAQF+DFSSKYGsFatpSEEV	...................................................................................................................................................................................................................h.th-.Elpsa+.sE--Nu+hVp+AspVhsRM+tsE.plppLElsNhDL.tKLp..........................hpth.EtQt.hl..tR............................................	0	6	6	6
+299	PF04641	Rtf2	DUF602;	Rtf2 RING-finger	Mifsud W, Pollington J	anon	Pfam-B_5482 (release 7.5)	Family	It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilizes the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site [1]. This domain is also found at the N-terminus of peptidyl-prolyl cis-trans isomerase 4, a divergent cyclophilin family [2].	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.05	0.70	-5.19	23	575	2012-10-03 15:03:13	2003-04-07 12:59:11	7	9	286	0	402	606	6	231.20	20	66.07	CHANGED	MGsDGGoI..PpRcELV+h.........+++scpl...............D.ppt.ptt+WphCuLopc.Lpc...PIVsspLGpLYNK-sllchLL-Kp....thscsss......HI+uLKDlhpLplosNPs.pttt............psspps.alCPloul-h.sGph+FhhLhsCGCVFSE+AL+-l.....K...sch......................C.hCspsas.pc............Dl...ls........lNsocE.-h-hh+tch.cccpuc......pKpcKcpK+pKpstssusstpsstsstsst.................................tt..tt..t..phtptpshsppsppscsap.........SLFsoppppK	......................................................................................................................................................................................................................aphCsL.S.p.hp................P....l..ss....GplashpsllphLh..ptt.........s..ttht.....................................+lpsl....K-lh.cL.p.hsts.................................................pcspa.h.CPls..t...pth.....sspp...+hl.hl...t..ssG....s....V..ao....tcAlc..cl......c.........sph..................................................C...hh...sspsap...cp................D.l...Is.......................lp.....s.........sp.........p.......-h..........th......h.p.p..ph...pthp..p...............tp.t...pp....t.ct..t...t..................t......t......................................................................................................................t.................................................................................................................................................................	0	152	233	342
+300	PF04652	DUF605		Vta1 like	Mifsud W, Mistry J, Wood V	anon	Pfam-B_5537 (release 7.5)	Family	Vta1 (VPS20-associated protein 1) is a positive regulator of Vps4.  Vps4 is an ATPase that is required in the multivesicular body (MVB) sorting pathway to dissociate the endosomal sorting complex required for transport (ESCRT).  Vta1 promotes correct assembly of Vps4 and stimulates its ATPase activity through its conserved Vta1/SBP1/LIP5 region [1].	24.70	24.70	24.70	24.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.38	0.70	-5.06	39	629	2009-09-11 15:36:18	2003-04-07 12:59:11	11	22	297	9	412	611	7	210.40	18	49.99	CHANGED	pslp.alppApEh-ptc.PllAYaC+haslpphlchst..pssEsppah....hsLhDpLE...................phKpphs......sp.......cslh.scssupualEpFALclFspADpp.Ru.sp..hs+.sss+sFasAuhhh-llphF...Gp...................l....sp-stp+hKYAKa+AscItKul+pG........csPssss..hp-pcpt.............................................................................................................................................................t.sstssssssstsssp..s...........t.s.t..s....sss.PssP...........................................Pss......s.ss...sst.....st...............................................tstPsspp.s................................................sht.sscplspAQKaA+aAlSAL....sa-DlpTAhcpLppALclLs	..................................................................................................................................................................................................................................h.hu.pht.............................hhsahh.......thahhp.....h...ht.............ts.t..thh........lhp.....lE...................t.p.tt......................................................t.....hh.tah.thh..t.pt..p........t...................t.....hhp.h.ss..hhphh.t.h.......t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	142	230	338
+301	PF04678	DUF607		Protein of unknown function, DUF607	Mifsud W	anon	Pfam-B_5620 (release 7.5)	Family	This family represents a conserved region found in several uncharacterised eukaryotic proteins.	23.80	23.80	23.90	24.20	23.40	23.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.14	0.71	-4.35	41	400	2009-09-11 03:12:19	2003-04-07 12:59:11	8	11	197	0	257	399	0	179.00	27	53.31	CHANGED	ht.........hpstscutchssslcsuushl.slpssV..hlp.................Ppt...............hhthlt.hhsh...t..t.pp..............hlcphppclpslpchKpphcptAc......ppsp+lhWuGluhlu.sQhullh+LTFa.-huWDlMEPVTYalohushhsuYsaFLhppc-hoYpuhhcpphst+.c+hhptpsFDlpc.......YpcLp	....................................................................................................................s........tt.tpuhphsthhptsushl..hpshh........hL.....................................Ppp.................................hhphltthhsh.............tpt...h.............plcphcppL.psLp.phKtclcptAc......ppsptlh.WuG.Luhhs..sQhGllh+LTaW..-aSW...DlMEPlTYFlThushh.s..s..YuYFlhTp.p.-hsYpshhppphhtt.c+hhppppFDlp+YppL..................................	0	78	135	199
+302	PF04685	DUF608		Protein of unknown function, DUF608	Mifsud W	anon	Pfam-B_5657 (release 7.5)	Family	This family represents a conserved region with a pankaryotic distribution in a number of uncharacterised proteins.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.21	0.70	-5.74	46	661	2012-10-03 02:33:51	2003-04-07 12:59:11	8	24	450	3	246	857	87	284.20	22	30.49	CHANGED	GcFshhEuh-h.thhsohcsphY..uShuLhhLaPcLEcolhpshspsh.pps.........................GslPHDlGhs............cpPh.tss...hp....ssttWpDLsssaVLpVYRDa..hhoG-...................................................................ps...aLcphaPsltpul-ahh..p......aDpD.sDGl.-ssst.D....................................pTYDsh...hhGsouYsuuLalAALpAuhphuchlsc.........................ttptppapphlpcu+phhcch.................LWNGc..Yat..hD....................................ptphupulhuDQLhGpa...auphhGL.....ssllsc-phcoALpslachNhh.............hhhsuchGssNuhhP.......cGp............hc.ssspspE.VWo.GlsaulAAhhl.cGhh-c.uhclscsshpphh...phGh.appsEsh...t.......hhuspYhRshuhWuhhh	...............................................................................................................................................................................................................................................................................................-........hh..hh..h.............t....................................................................................................................hh.t..ha................h.ht.....hht........t......hs.p...t..sG..h.....p..s...t.h......................................................................................................................................................................p.h....h....D..s.......h.........h.....t..G......S...u....a.........s.....u..tL...a...h.s..AL.....p...u...hhthA........chhs.c...............................p.t.t.sp.pa.pthhpps+psh-pp........LW..s...Gc......aat..h...............................................................................................s.p.ptsc.h...hs-QltGph...ahp...s.uL...........s.h..hspc.+sppAhpslhch..h............................h.s..sphGhssthh...............sst.................s...hp...................................................................................................h.........................................................................................................................	0	82	143	207
+303	PF04727	ELMO_CED12	DUF609; 	ELMO/CED-12 family	Mifsud W	anon	Pfam-B_3095 (release 7.5)	Family	This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells [1]. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.	20.60	20.60	21.80	21.90	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.03	0.71	-4.71	60	873	2009-01-15 18:05:59	2003-04-07 12:59:11	8	24	242	0	533	801	13	171.00	26	34.37	CHANGED	pphphlcphtphshDspp...............................spHpch.........LppLaphhhss........................................tphssphsp................pWcclGFQ.upsPsTDFRus..GhLGLhsLlaascpaps..thpclLppspptt...........................................................................................paPaAlsuIslTt................hlhphl..ch.sph...........stcthpsh.............................htsthpsFpcLashshhtFschWh...................pptsslh-Fsplhp	................................................................................................h...t.lcphhph.hDsps................................p..H...pch.........LhpLaphhhss.................................................p.hpshhsc..................pWc.clGFp.s....s..sP......ssDFcs.s..GhLuLtsLlYFuc..p...ats..thpc.llhcspppp........................................................................................................................................h....phPFAhsuIslTp................hlhphL.ch..sph.......................pscthpth...................................................hhsp.psFppha.shsh.hh.s.+hWh...................phts.oh.-FspVh.........................................................................................................................................	0	181	274	395
+304	PF04747	DUF612		Protein of unknown function, DUF612	Mifsud W	anon	Pfam-B_3614 (release 7.5)	Family	This family includes several uncharacterised proteins from Caenorhabditis elegans.	18.30	18.30	18.80	27.70	18.20	18.20	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-13.08	0.70	-5.60	2	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	4	0	25	45	0	198.90	36	72.46	CHANGED	MRSPKSVRRPHIRQQLTNRRKNLGRVAKSQRNQFRQWLLTAVLPNSINDQRKEAFASLELTEQPQQVEKVKKSEKKKAQKQIAKDHEAEQKVNAKKAAEKEARRAEAEAKKRAAQEEEHKQWKAEQERIQKEQEKKEADLKKLQAEKKKEKAVKAEKAEKAEKTKKASTPAPVEEEIVVKKVANDRSAAPAPEPKTPTNTPAEPAEQVQEITGKKNKKNKKKSESEATAAPASVEQVVEQPKVVTEEPHQQAAPQEKKNKKNKRKSESENVPAASETPVEPVVETTPPASENQKKNKKDKKKSESEKVVEEPVQAEAPKSKKPTADDNMDFLDFVTAKEEPKDEPAETPAAPVEEVVENVVENVVEKSTTPPATENKKKNKKDKKKSESEKVTEQPVESAPAPPQVEQVVEp.......................VEcPV..APsSKKPTADDsMDFLDFVTAKP-+oEss.......h.VEss+s-ppTAssuts+KKNKKsKpKppSEp...Ess	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tts.t..ss....ss.s.....SpKPTAD.sMDFLDFVTAKs-cs-.s............h....p.....................................t..........................................................................	0	3	9	25
+305	PF04749	PLAC8	DUF614; 	PLAC8 family	Mifsud W, Bateman A	anon	Pfam-B_3635 (release 7.5)	Family	This family includes Swiss:Q9NZF1, the Placenta-specific gene 8 protein.	21.40	21.40	21.40	21.40	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.97	0.72	-3.48	114	1148	2009-01-15 18:05:59	2003-04-07 12:59:11	12	23	216	0	794	1125	22	103.20	24	44.26	CHANGED	WssGLh...cCh........s.Dhs...sChhshh.sPChhhuph......uphhsttt................ssCshhshhhhhh............................h.....shhRs.plRpcasl............pu..s.sssDshhph.hC.sCuls........Qpt...RE...l	............................................................................................Wpsul.h.s..Ch..............s..D..h.s.........hC.hhshh..CP...C..h.hhuphtptlt.t....................................spChhhshhhshh...........................................................h......hh..hs.....shhRtplRp+a..sl...............................ps.....s...ss...sD..hhs.th.hC..sCulsQthRE.................................................	0	276	496	660
+306	PF04759	DUF617		Protein of unknown function, DUF617	Mifsud W	anon	Pfam-B_3842 (release 7.5)	Family	This family represents a conserved region in a number of uncharacterised plant proteins.	20.90	20.90	21.40	22.00	19.20	20.60	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.07	0.71	-4.60	23	195	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	19	0	135	184	0	163.50	47	61.51	CHANGED	plTGTlF.....GaRRG+VshulQ-sspus..Psl.LlELAh.sTusLh+EM..uuGhVRIALEs-+p..sspsstt...........................LL.-EshWshYCNGRKsGYAlRR..Eso-sDhtVLchLcsVShGAGVLPu............ttsssst-G-lhYMRA+FERVVGS+DSEoFYMlNP-.......Gsu......G......PELSIFhlRs	.................................lTGTlF.....GaR+G.+VphulQccs.+us.......Ps.l.LlELAh.sTusLs+EM..uuGlVRIALEC-+ppspp.s.........t..............................Ll-EslWshYCNGRKsGYAlRR...-so-sDhpVLchlcsVShGAGVLPs.................ssssus-GElhYMRA+FERVVGS+DS..EuFYMhNP-.......usu..............G....PELSIFhlRh....................................	0	15	75	104
+307	PF04818	CTD_bind	DUF618;	RNA polymerase II-binding domain.	Mifsud W, Eberhardt R	anon	Pfam-B_3687 (release 7.6)	Family	This domain binds to the phosphorylated C-terminal domain (CTD) of RNA polymerase II [1,2].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.19	0.72	-3.73	41	1005	2009-01-15 18:05:59	2003-04-07 12:59:11	8	25	269	19	650	939	0	63.20	28	8.67	CHANGED	KLshlYLsNDVlQpu.K++...ph.pFh....psFssllssshpplhpph..spchcpplpRllslWp-Rslas	...+LshlYLhN-llp..pu...++p.............pt.pFh.............tpFppslssshpp...l...h...pph.......spcs+ppltR...l...lsl...Wpcpslat................	0	167	294	487
+308	PF04789	DUF621		Protein of unknown function (DUF621)	Waterfield DI, Finn RD, Fenech M	anon	Pfam-B_6219 (release 7.5)	Family	Family of uncharacterised proteins. Some (such as Swiss:O01625) are annotated as having possible G-protein-coupled receptor-like activity.	20.80	20.80	20.80	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.99	0.70	-5.42	14	52	2012-10-03 04:04:29	2003-04-07 12:59:11	10	4	6	0	48	64	0	200.60	40	89.57	CHANGED	huElPsp-KsslYYhlloLFVlSTlsoTLLTuuFLllullLWu+FKs........MKFFWFLoQLTlSVFIlSsLNLlINVPATLFSLlTK-FlpSclFhhlSYlIDFCHYoILFSNLVIAIQRhhVFFaRpl.TsphF-S.lIYhWLl.VWlluhhlhhhhhhsNC+Ypapp........ps..p+Y.LpCpst...sslVshssPphIQl................lEhllQhGIPlhILslYlAllhKIhhMKpooLsKsEhplLKQAIFlFllFQsSSsVFLhsQTlphsssTAFLIKRhINT..............hEIhAGAATPCFFFFTSKEIRKllSoKlSAsSSQGsS	............................................................................................pt.haa.hl.hFlh..hhsolLohsFlh.h.hhhW..h+...............h+aFWFL.pLThuhFlhS..NhhlslPAsL.ulho.phhpo...............t.a.hh....ph.h..hlhsNhhhu......................................................h.h................h.h.C.........h.........h................h-.h.hQhhlPhhI.h.hhYhulhh.......+lh.h.h..Ktss.p...p.......EhhlLhQuhhlFhhFQhss..lhhhs..h....t....AFhlK+hlpT...............h.-............................................................................................	0	14	17	48
+309	PF04802	SMK-1	DUF625; SMK-1_Ce; 	Component of IIS longevity pathway SMK-1	Waterfield DI, Finn RD, Wood V, Mistry J, Pollington J	anon	Pfam-B_6319 (release 7.5)	Family	SMK-1 is a component of the IIs longevity pathway which regulates aging in C.elegans. Specifically, SMK-1 influences DAF-16-dependant regulation of the aging process by regulating the transcriptional specificity of DAF-16 activity [1]. SMK-1 plays a role in longevity by modulating the transcriptional specificity of DAF-16 [1].	21.40	21.40	21.60	21.90	19.90	20.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.26	0.71	-4.78	25	450	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	272	0	288	477	3	185.10	41	22.89	CHANGED	l.scsYlp+L..lslFctsE-l.-shcsLHhLpsIlK..........sllLLNcsslhEhllu.D-hlhslVGsLEY.....DP-hPp.sK.pHRpaLpppu.+FKEVIPIpssplppKIHQTaRlQYLKDVVLs..RlLDDsshusLsohIahNps-IlshLQcDp.pFLpELFuhh..................pssssss-+++-hlhFL+-hCshu+sLQs.....s+ppha+sL	......................scsYIcKL..lpLFchCE-L.Esh-sLHpLapIlK..........uIl...h..L...N.c..ssl..hEhh.hS.D.-sIhcVlGsLEY..............DP.sh.s.p....s+....p....H.R.caLpcpu....+FKE.....................Vl..PIp...-s...p..l...h...pKIHQTYRlQYlpDllLs...pl..h--shhSsLsShIFF.N.pl-I.Vs..hL..Q..cDp...pF...Ls-LFuth........................................................................s.sp...ss.s.p..c++c-hV.Fl+-hCshup.sLQs.....s+pshacsL...........................................	0	91	148	218
+310	PF04783	DUF630		Protein of unknown function (DUF630)	Kerrison ND, Eberhardt R	anon	Pfam-B_2481 (release 7.6)	Family	This region is sometimes found at the N-terminus of putative plant bZIP proteins.  Its function is not known. Structural modelling suggests this domain may bind nucleic acids [1].	21.30	21.30	21.30	21.70	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.85	0.72	-4.07	33	295	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	25	0	203	284	0	60.00	42	8.62	CHANGED	MG.CstS+.l-.......s-........-sVthC+-R++hlKpAlctRpsLAuAHsAYhpSLRssGsALpcFspsEs	..................................MG.CstSK.l-.......p-..............-uVshC+-R++hl+pAlctRtsLAuAHsuYhpSL+ssGsALppFsps-.................	0	21	111	159
+311	PF01683	EB		EB module	Hutter H, Bateman A	anon	Hutter H	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains Pfam:PF00014.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.12	0.72	-3.90	63	858	2009-09-13 14:03:54	2003-04-07 12:59:11	13	76	43	0	729	809	1	57.00	25	22.16	CHANGED	C.s...........sh....hhhsspChsp.................................................st.Gps.Cp.hspQCt....ss..otC..hs....u.....pCpCssu.........hpthsst..C	............................................................................................................................tstCh.t..................................................s.t..Gps.Cp..ts...ppCt..............ss..ShC...hs......u.........hCpCss.u.........hh....s.shC....................	0	278	372	715
+312	PF04782	DUF632		Protein of unknown function (DUF632)	Kerrison ND	anon	Pfam-B_2481 (release 7.6)	Family	This plant protein may be a leucine zipper, but there is no experimental evidence for this.	19.50	19.50	20.20	19.60	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.95	0.70	-5.33	33	381	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	30	0	243	367	1	266.10	28	43.51	CHANGED	slh-llc-I-chFh+Aupuup-VochLEs....s+......h.appp.sphpt.............................uuplhpslohs...hs.ts....................htptsssttss.ts.tstoauoTL-+La.AWEKKLYcEVK.....................upEpl+hpY-KKhppLpph-t+Gscttpl-+T+sslpcLpo+lhlshpslsshSppIp+LRDcELhPQLl-LlpG.............................Lh+MWcsMhcsHchQhpllpps+..lst.....stsp..............so-tappsThpLEsplppWpssFssalssQ+sYlpuLssWLphsl........tpppt..s.s..p..sPslashCppWppsl-.cls-ctstcAlcuFssslpsl	...................................................hhphhp-lcp.F.+AupuupcVuthLEs..s+.......ht..hptp...t..t.th...........................................................ttphh.pslsht......hs.ts.............................t..s...s.h.tt...s....stshuoTL-+LhsWEKKLYcEVK....................................................stEth+hta-+Kht.Lpp.-.+G.tp....pl-+T+s.lccLpo+.lhlshpshpshoppIpclRDpELhPQLh-LlpG.............................hhpMWcsMhcpHphQhphlpphp..hs......t.....................psc.pt..ptshpLc.tlppWtssFsphlptQ+sYlpuL.suWLph..sl..........t...t......s......p.h.ssslhshsppWtttlc..plspp.......s.pulcshhtslp.............................................................	0	26	142	192
+313	PF04826	Arm_2	DUF634;	Armadillo-like	Kerrison ND, Eberhardt R	anon	Pfam-B_2700 (release 7.6)	Family	This domain contains armadillo-like repeats [1]. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis [2], control of cellular ageing and survival [1], regulation of circadian rhythm [3] and lysosomal sorting of G protein-coupled receptors [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.57	0.70	-5.27	11	392	2012-10-11 20:00:58	2003-04-07 12:59:11	8	14	78	0	216	672	4	217.60	29	44.07	CHANGED	sssphcsh.Lssp-LcKLLslLcpTcDPhIpEhALlsLGNsAAashNQ-IIR-lGGlslIushlssssspl+.pKALNALNNLSsNsENQpclKsYlsQVC-DlhssPLNSsVQlAGL+LLsNhTVTs-YQHllss.lssFhpLLstGNscTKhplLKlLlNhScNPuMT+cLlsspVsSSLluLFspp.s+ElLLplLplFpNIscplKtcuplssppcFocuoLF.hlhp-sp.hspKlpuLssH.pDs-V+tKVl	...........................................................hsstph.pc...llt.llchopDPhIpphuhhsh.up.s.s..s......a.s.h......s.p...........sh.I+c.h..Gsl.sl.ltsh.l.s.p.s.s......s....pl+....ppA....Lpsl.s...sh.oss....h-N..pt.p..l...c...h......a..l.s.p.Vsc....-h...h.s...t..s.l.......s..S...s...l.Q..h...u...G..L+hLsph..T..........l...s..sp..h..p..p...h..l...s...s.......h...s...s.h.h...p.....L.Lst.G.st..p.....s+.hplLK.lLhN.loc.NPsh....sc..c.Lls.s..p..s...ushh.sLas.....pp.spp.llphlshhppltpth+.t......s....p.......as.tsLh..hhtp.t.....hspph..t........................................................................................................	0	33	46	80
+314	PF04859	DUF641		Plant protein of unknown function (DUF641)	Kerrison ND	anon	Pfam-B_6069 (release 7.6)	Family	Plant protein of unknown function.	23.10	23.10	23.10	24.10	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.60	0.71	-4.40	13	143	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	20	0	98	139	2	124.70	33	29.11	CHANGED	spstspsspsh-ulluclFuslSSlKuAYhpLQpAHsPYDs-pIQuADpsVVuELcpLS-LK+tat+ppsssu.....spssthhAclpEpppLl+TYElhl++..LctElcsKDsEIcpL+pplppthtssppLEK+l	..........................t....pphtsh-ulluclFsslSulKuAYhpLQtApsPYDs-pIpuADphlVuELcpLS-LKchahcpphs.ss...............................st.sh.hhuph.pEppsll+o.YEhhsc+..LpuplptKDuElttL+pplpctt.ptspplpc+l................................	0	14	62	80
+315	PF04884	DUF647		Vitamin B6 photo-protection and homoeostasis	Mifsud W, Eberhardt R	anon	Pfam-B_6523 (release 7.6)	Family	In plants, this domain plays a role in auxin-transport, plant growth and development [1,2] and appears to be expressed by all cells in the plant as well as in plastids. The family has been shown to play a role in vitamin B6 photo-protection and homoeostasis in plants [3].	28.30	28.30	31.30	29.20	28.20	28.20	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.45	0.70	-5.20	27	424	2012-10-10 14:40:21	2003-04-07 12:59:11	9	9	206	0	293	410	13	219.60	31	52.45	CHANGED	sptshph.pthpphhshlhphFLPpGYPpSVosDYlsYtha........cslQshsSslsusLuTpAlLp.u...................................lGVGs.......ssAsssuAslpWlL+DuhGtlupILFAthh............................GotlDs-sKpaRlhADllsDhAhhl-l.loPhaPp......hhlhlhssusls+ulsuVAuGu.o+AuLotHF.AhpsNLA-lsAKssuQpTls..sLlGhhlGh.......hlsshls......shtsshhs.hhhlsslHlhsNYpAVRuVphcTLNcpRsslllppalps.upl.	..............................h.............hthhhthhlPtGaPpSVos-Yh..Ytha.....................cslQ.shsoshtusLuTpulLt.u................................................................................lGV.Gp........tsus..stuAs..lpWll+.Du.hGhlupllFuhh..............................................................G..sphDscsKp......aRh...hA...........DllpDhuhhlEl.hoP.....h.h.Pt..............hhl.lhshuslh+ul..........suVuu................uu.T+uulptHa...A.................h....p.....s...Nhu-lsAKs...............tuQpsls..slhGhh...lGh...................hlhphls........................s..hhhhs..hhhlshlHlhssapul+ul.hpTLNttRhpllhppahpp.s........................................	0	105	187	246
+316	PF04900	Fcf1	DUF652; 	Fcf1	Mifsud W, Wood V, Mistry J	anon	Pfam-B_6634 (release 7.6)	Family	Fcf1 is a nucleolar protein involved in pre-rRNA processing [1]. Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits [1].	21.40	21.40	21.50	21.50	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.51	0.72	-3.92	60	807	2012-10-03 20:43:45	2003-04-07 12:59:11	7	10	439	0	568	803	47	95.30	35	44.72	CHANGED	hcsLhu...cspshlTpCVltELcclu..phpsulplsps.p.hpRhpCsHpss.......Ac-CIhphV..s........pc+.........YlVATpDp-L+++lR.+lPG.VPlhalp.psphhlEph	................................chLhu.csh.hlTpCVhtELEcLG....t.c....hp.hAh.....p...........lA..+...c...............t...hpc.h..p....CsHpss.....................h.A--Cllphl..p......................................ppc...........YlVAT......pDp...........cL+++lR.clPG.VPlhalp..ppphhlEt..................	0	188	312	453
+317	PF04949	Transcrip_act	DUF662;	Transcriptional activator	Finn RD, Eberhardt R	anon	Pfam-B_6952 (release 7.6)	Family	This family of proteins may act as a transcriptional activator. It plays a role in stress response in plants [1].	27.20	27.20	27.20	29.60	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.09	0.71	-4.60	6	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	19	0	44	72	0	147.50	58	88.85	CHANGED	Qh.plhsppoGulShsG.usthc-c-EEhSRSALSsFKAKEEEIER+KMEVRERVQAQLGRVEEEoKRLAhIREELEuhuDPhRKEVsslRK+IDsVNRELKPLGpTCQKKE+EYKEsLEAaNEKNKEKApLloKLhELVuESE+hRMKKLEELSKolEol	....................h.t.su.uhuh....us.thsc--EEhSRSALSsF+AKEEEIE+KKMEVREKVpsQLGRVEEETKRLAhIRE.............ELE.......uhADPhRKEVuhVRK+IDsVN+ELK.PLGpoCQKKE+EYKEsLEAFNEKN+EKspLlo+LME...LVuESE+lRhKKLEELsKsl-oh.................	0	11	27	34
+318	PF04950	DUF663		Protein of unknown function (DUF663)	Moxon SJ	anon	Pfam-B_5147 (release 7.6)	Family	This family contains several uncharacterised eukaryotic proteins.	20.20	20.20	20.50	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.82	0.70	-5.45	11	954	2009-01-15 18:05:59	2003-04-07 12:59:11	7	33	507	12	524	951	15	256.70	33	35.98	CHANGED	El-hs.c.sAcpchpKYRGL+uhhsSsWDssE........s.Pp-apclaphpNhcpoKpphlpp..............pt.hpsshsGtaVplhlcpVPhphhpsass....tp...sl.lsauLL.aEpKhullshpl++apthccPl+o..p-pLllphGaRRFhs................pPlaSp....sssss+pKhpRahpscpsssAThYuPlsassssllsh+p.psssp.............hplsAoGsllsssssphlhK+hlLsGHPaKIaK+suslRYMFassEDVpaFK..............................slplhT+sGR+GhIKEsl.GTH.GthKsoF-s+lpspDsVhhpLYKRV	...........................................................................................................................................................ht+hp.tl+thhsu.a-stE.........................st........c....a..pclh.p..h..t....ch....c.t.....p..+.....p.p.hlpc..........................t.h.tGhpsGh..hVcl..plcs..V.P..sphhp.php.............................Pl..hlhuLLtpEp+.hshlphplp...t..p..........p.h....c..c.s.lKo..+-.LIhphGhRRh.s....................tPlaSt.............pssssh...p+h.+ah....t.h....p.shAo.ahG.............Plsh..s...s...s...shls.a..pphp.sps...................................................thcl....huTGsllss..D.......t....sphl...sK+l...hL.sG..........h..PhK.Ih+..p..hshl.+.MF.s....-lthFc..............................shtlh.Th.t.G.hpG.IKcs............l....t...................s..............c....Ghh............+s.Fpspl..p...Dhlhhphah.h................................	0	197	301	442
+319	PF05057	DUF676		Putative serine esterase (DUF676)	Moxon SJ	anon	Pfam-B_5941 (release 7.7)	Family	This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.53	0.70	-5.05	14	1193	2012-10-03 11:45:05	2003-04-07 12:59:11	9	58	403	0	795	2452	363	177.00	20	25.94	CHANGED	spptsHLVVhlHGl.us..........ssDh........phltpplhp......phspc..hlhhhsppsstspThsGlch.hGcRLspEllphlpctpst..........KISFluHSLGGLltRhAluhlh.t......................httlcshsFlolAoPaLGshhspss.........ptlptshuhthlspoGppL.hh..............Ds.cspsshLh+l.tptst..hhps.......LthF.............KpRllauNs.pDthsshho.....sph	.......................................................................................................................t....pl..hlhhHG....l.us.................................tc..h............................................h.ht..p......h................................t......tt.......h....h....h..........................p....t......s.................p.....T..........t....s........hc.......h.....s..p...+...l.......h..p.....p......lh.p..h.l.p.t..h..t.t....................................p+.l..S...a..luHSLG.G.L.l.h.R.h.u.lshhhtp...........................................................p.....h..s..F.....l........o....l..uo.....P.H.......lGs............hh.tp.........h.........................................................................h...h................................h...shp..........................................................................t...........hh.h...............................................h..F......................p.h.hhs....D..s...........s.h..............................................................................................................................................	1	242	449	666
+320	PF05097	DUF688		Protein of unknown function (DUF688)	Moxon SJ	anon	Pfam-B_6331 (release 7.7)	Family	This family contains several uncharacterised proteins found in Arabidopsis thaliana.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.90	0.70	-5.54	7	218	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	22	0	135	189	0	203.30	14	61.22	CHANGED	ME-..KpLshstPLhSlRRhsph...s...pp....p..s.hp.....hP.hcs-h......pp..s.VppPuoVPFhWEQtPG+PK............st.ts...........................................................................................tcss--p-sth.-AhDTlSpstSF.hNCS.sSGlSthttss......ss.ss-..hpspDhMMuRFLPAAKAhslcp.spasu++ps.....sh.pp.hpQltchh...........sucp+ss.s.Yc.phsss....p...hcD-Ep--ps--Dt........h..ophhup+sCGhL.PplChKsSlshLNPVsuht.t....lpssSpctsK..u+hs....t..o.pK........uhs.h.c+KLpthhp.sht.s.spphpspSpp.p.h...Sps.psSp.hht...ttth.P.acsss..S..........................hpphpc..tELhhs+sshptst..Sshh-+Tlassp.p......................................hlE	..........................................................................................................................................................h.p...su.u......VPFhWEppPGpP.K........................stt..p..s..................sP................................................................sP...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.ht.tt..................................................................................................................................................................................................	0	23	78	104
+321	PF05108	DUF690		Protein of unknown function (DUF690)	Moxon SJ	anon	Pfam-B_6322 (release 7.7)	Family	This family contains several uncharacterised bacterial membrane proteins.	19.20	19.20	22.70	20.60	18.00	18.40	hmmbuild  -o /dev/null HMM SEED	483	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.67	0.70	-6.12	7	613	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	233	0	136	440	0	410.80	30	94.49	CHANGED	hshshoT+hQVoGaRFlhRRlttAlshtDsRMhsDPLRtpopulslGhllslshhhGshlhuhl+PpGtlGsssllsDRsouALYVRluspLaPVLNLTSARLlsGpssNPtsVKSSELs+hPpGsLlGIPGAPtths..sssssSsWslCDolutstSp....sstsTVIAGPh-.su.ptssLpsspulL..Vsh....susTWllhsG+RutIDLsD+AVT.uLGlss....sstPpslupuLFNAlP-ss.lpsPhIPsAGuPsShGlsss......IGuVlph.......ps.ssusQYYlVLsDGlQplssssAslLRsssSaGhstPPslsPshls+hP.sppLssphaP-pPlphVD...tstsPshChhWp+sAusssuplslluGpsLPVssu....sVpLsps.t.s...sAspVhlssGtutFVsspu..ssutsotSLaaVossGVRaGlssscs............scALGLs..ss.sAPWslLpLhssGPsLSRssALLtHDTLssDs	.........................................................................................ss+.QVoGapFlhRRhttulshtcs.c.Mht-....Ph+ppstulhhGhll...sllhhhGsh...lhu.hh.....p...P...s..u.....t...h.....u.....s.s...s..l..lss+pouuLYV..h........l..........s.........s.........p........L+PVhNLsSARLl.s..................G.......p.s..s..s.P..t..h..Vp...ss....pL..s..p....h..P.pGshlGIPG..APtth.s........ps.s..s..s.u..............s..Wsl.C....D......s..s.s.ts......ut................st.s.osl........ss.....s..h.p.ss......th..........t..Lt..s..sp.ul..L..lph..................sus.s.a.l.l........h...........s...........u.....p...........R.....t....l.....-....................s....s....p.......A....l.h......u.LGls...........stsp..lupulhsulPtss...s...lt....sP....t...l...s.......t..u...G..s..s..s..s...h...s.h..ss........lGsVhth....................................s...ss.s...paYllL.DG.lttl.s.h.hAtl.L.......p.....t....s......s.......u.............G............s...t....s.......t...ls..s..s......l...s....t.........h.....P.....s.....p............l......s....s..p......hP.s..t.....ph...ls.........htt.t.s.....s.hCh.Wp........s.........s...s..............t...t.......tsp...htl.....h.s.Gt.th.P.ls..s.........htls.ts.................s........sstVhlssG..t..u..t.aVt....stu................s...sts.s....t..o.h..a.h.lo-sGlRault.s..s..ps.............................hcsLG...Ls..............ss..........sPWsllp....hlssGPsLS+ssAhhthss..............................................................................................................................	0	31	85	123
+322	PF05127	Helicase_RecD	DUF699;	Helicase	Bateman A, Eberhardt R	anon	Pfam-B_884 (release 7.7)	Domain	This domain contains a P-loop (Walker A) motif, suggesting that it has ATPase activity, and a Walker B motif. In tRNA(Met) cytidine acetyltransferase (TmcA) it may function as an RNA helicase motor (driven by ATP hydrolysis) which delivers the wobble base to the active centre of the GCN5-related N-acetyltransferase (GNAT) domain [1]. It is found in the bacterial exodeoxyribonuclease V alpha chain (RecD), which has 5'-3' helicase activity. It is structurally similar to the motor domain 1A in other SF1 helicases [2].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.22	0.71	-4.64	106	1317	2012-10-05 12:31:07	2003-04-07 12:59:11	9	23	1199	2	421	2768	389	161.80	45	21.72	CHANGED	llTAsRGRGKSuulGluhutlhtpth.......plhlTAPshpslpslapashpshp..........................ttt....htht.......ttplpahsP-shhptt.ts............-l.......LllDEAAAIPlPlLcpl...ltta...+llh...........uoTlpG....YEGoGRGFsl+Fhpt.Lcpp.......................................ts.phpplpLppPIRautsDPlEpW.l.chLlLc	............................................................................t.lTAsRGRGK.SA....h....h....G..h.h...l..u..p.h....s.up.............................hhVTAP...u...hsusc...s.L.h.p.F.u........................................................................................................................................tpph.p...F...l...u.PDsLltp.....s.....pA....................................................Dh.......LllDEA.......A.A.I.Ph.P.L..LcpL......lt.t...a.....+s.lh.....................o..oTlpG.....................YE..GTGRGF.LKFhsph......................................................hs.pl+chpLppPI.RaAtsDPLEph.lschLlhD......................................................................................................................................................................	0	132	223	339
+323	PF05129	Elf1	DUF701; 	Transcription elongation factor Elf1 like	Bateman A, Wood V, Mistry J	anon	Pfam-B_8884 (release 7.7)	Domain	This family of short proteins contains a putative zinc binding domain with four conserved cysteines.  Swiss:P36053 has been identified as a transcription elongation factor in Saccharomyces cerevisiae [1].	27.40	27.40	27.40	27.50	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.27	0.72	-4.29	37	383	2012-10-03 10:42:43	2003-04-07 12:59:11	8	4	317	1	269	345	1	79.40	41	60.55	CHANGED	G+RKppp+...s.tp....+th.pLspt....FsCsFCsacpSlplpl....c+p......pthuplpCplC..stpa.psp.lstLspslDVYucWlDtscpss	..............................G+RKppp+......s.stp....KhttpLs..opFsCPFCNH-pSlpV+h......D+p..........pshGplsCplC...........tppF.pTs..Is.h.......LopPl...DVYS-WlDAC-th................	0	89	147	218
+325	PF05197	TRIC	DUF714; 	TRIC channel	Bateman A	anon	Pfam-B_9855 (release 7.7)	Family	TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalent cation-selective channel [1].	25.40	25.40	25.70	27.50	24.70	25.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.23	0.71	-4.89	13	194	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	104	0	124	182	0	184.70	41	61.19	CHANGED	l+c...pPGAlshS++sPlAsWLSuMLaCFGGulLushLLGEPPltsLsNsssILLAoslWYLVFYCPhDlhY+hssaLPl+LllsuMKEVsRshKIsuGVsHAtchYpcualVMlllGasKGAGuullpshEQLlRGVW+PEoNEhL+MSFPTKsoLlGullFTLQ+sphLslupHsLhahaTl.FhVhhKlsMhhhpsp	......................tsGu.thuR+pPlusWLssMLhs....FuuslLushLLG.EP.......ls.hpNssslLLAosl.WYllFasPhDlhY+sssa.....LP.V+llhsuM.KElhR.spKIhs.GVpHA....t+.hY....puall....MI.hlGhl+...GuGuul.hpshEpLlRGs.W..p.P.p..s..s.EhL+.SasTKsoLhuu.l.l.FsLpppp...h...Ls.huppsLhahhhl.FhVhhKl..hhht.................................................................	0	36	46	84
+326	PF01031	Dynamin_M	dynamin_2; 	Dynamin central region	Finn RD, Bateman A	anon	Pfam-B_220 (release 3.0)	Family	This region lies between the GTPase domain, see Pfam:PF00350, and the pleckstrin  homology (PH) domain, see Pfam:PF00169.	24.60	24.60	24.60	24.80	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.70	0.70	-5.64	93	2249	2009-09-16 15:19:57	2003-04-07 12:59:11	15	54	534	28	1262	2222	40	229.30	26	35.58	CHANGED	slDlLpsclhsL+hGYlsVhsR.uQpDIpspholpcAlcpEcpFFpsHstYps.hsctpGT.shLAcpLsp.LhpHI+csLPplcspIppplpphppELppY.Gssss...tstsc+sthllphlspFspsapsh.lcGpps..........ssp-LpGGu+IphlFpchhsphhps.hps..hpphhcc-lcphlcptpGhchshFlstpuFEhlVKpQIcpLc-PulcslchVh-tlpclhpphssp....phs+FPsLppplpshlpsllpcphpsscphlpshlchEtsalsTpc.sahsshp..thpp........ppppp	............................................hplltsc..h.h.......L+.h.G..........ahsVhN.........R.......uQ.t.....-...........l.........p.....t.......p.......h.......s...hp...t.........u.h.p.t.EptFF..t.p...c........................a.......p....p....h......s......p......p...hGo...hLtcpLs..........p.L.hp+Ic.pp.LP.t.l...csplpptht.phpp-lp.ph.sp.hs.........t...tpptthl..lph.....hppF...spt..hpph..l.cGptt............................pht.h.h...s....+l....................F....pp.h....h...........h...t....h......................t...............p...l..h...p.p.G............p.............hhhs...sac.ll+tpl.thlctPshptlphV..........h.p.l.phhpp.htt...............phtp.........a...P..t....Lppt..h..phh.phhp..pt...sp.p....l...........h.hthp.....h.h.......s....h..................pt.....................................................................................................................................................................................	0	336	647	994
+327	PF03028	Dynein_heavy		Dynein heavy chain and region D6 of dynein motor	Griffiths-Jones SR	anon	Pfam-B_928 (release 6.4)	Domain	This family represents the C-terminal region of dynein heavy chain.  The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains [1]. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained [2].	21.70	21.70	21.70	22.00	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	708	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.38	0.70	-13.22	0.70	-6.50	18	2690	2009-01-15 18:05:59	2003-04-07 12:59:11	10	239	285	14	1923	2507	199	542.40	27	19.03	CHANGED	hpsshssPh.-aLospsWsulptLsphpp...........FpsLscclcpss....ppW+pah-p-sP.EcpclPppWc..................ppsshpKLhllRslRPDRhshAlpsFlpptL..GpcaV-s.psl-hucsac.....-osssTPlhFlLSPGsDPhpcVEsLu+chG......ppapslSLGQGQth.lA-ptl-pAsKpG+WVlLQ........NlHLsspWLs.pLEKhL-phs....ssHscFRLFLoAEPsss.....lPhulLcsSIKlTNEPPsGl+ANL++uhss...hsp-hlEhss+p.sEa+sllFuLCaFHAVVtER++FGP.........hGWNhsYsFNpuDLphSlpsLpsaL-ts.........sKlP...W-sLRYlhGEIhYGG+IoD-aDRRLhpoaL-cahpsphh-s..-hhLsP......t.uatlPss.scacpYhpaI-p.LPsps.PhhaGLHsNAEIsahTppscplhsslLchQP+puus..ttGuu..hop.............................E-hlpsllc-ll-+ls...chFsht-lhtKhs....s.+sPhhhVhhQEh-RhNhLlp-l+pSLp-LshGl+GclshosphEsLhsuLhhspVPspWsphuYPShhsLsuWhsDLhpRlcpLppWspc........shPpslWLuGFFNPQoFLTAlhQshAR+N..pWsLDchsLps-VTK+pp-phss..s..............sc-G...saVaGlalEGARWDhp.pshlh-uc.K-LhsshPVlahKslsh..pctcpcshYcCP.VY+TcsRus.........saVashpL+o+c..psu+WlluGVALlhp	..............................................................................................................................tal.t..h.........t.h..h.........h....t.t...h.....t...................a.tt.....l.....p.pht..tt.............................ttW.p..t.h.h.pp..t.t..s........p....t........h..P.t.....hp.................................................ths.h.p......+....l....hll..+sh....RsD+..hh..sh........p.pa...l.............p................t..h..........G.............t.p....a....hps..........h.....s....h.tt....hp.....-osst....s.Pl.lhlL...............S.....s.......G......s......D........P.h..t..t..l.......t........hu.....pp.t................................tp....hpt..lu.h.G..Q.G..Q.t...hA....t..p...hlptu..h.p..p.G.p.WlhLp...........NsH.....L.s...p.a....h.....p.L..........-.c.h...h.p.p.ht............................c......sF...Rl.al..o..s..s..p..sp.............................hP...slLpt......u.....l.K.hs..E.....................sPt..........G...l.+tslhpsh.t...............................s....p.......h....p.......................s...t.....p..........t.....hptll..as..ls......ahHull.ER....++aus...........hGWsh.....Y..t..FspuDhph.........uh....p......l..p.....a.lpt....................................................t.p.ls...a.pslp.hhh.uph.......YGG+lsDsh.Dp+hh..shhpt....hhs....t...h...h..p.............t.h.h.........................................h.......h..P...............t...............p.........h..p...t.............a....h...p...a.......l...pp...L..............P.....................p...P.t.haG..hp...NA.chsh......t.p...s.p.t.....hh......pp..lh.h......p....st...st...........ttt...........s............................................................................pph...h...th...ht...p...hhpphs.............................h..s..........h..................p...h.............................p...s.h...............hhh.h..........pEh............php.Lht.lp..psL.p..........l.....h............s............l.p...G.....h......h...h.o..t.......t.h...c........t....h..pshh.s..........p.l..P.......t........W.............t......h.............s....h.s...s..............s.....ls.................aht....chh.R...h.t......hp.tWh.t..............................h.s.....hWlsuha..sp.u.aLT.....uhhQth..........sRt..........th..s.l.Dp...h.......hth.phh.....................................................................................................st.p..u.....hhl.G..Lhh-....................G.....Ata..................s.....t.......t........................l....................p.t......t......h..h......h.s...hh...h.h.....s....................................................................t..................h.......sP..lYh.......Rts.........................................hlh...h......l..............st.............th.ah.tGsshhh.....................................................................................................................................................	0	816	1017	1584
+328	PF04261	Dyp_perox	Dyp_perox_fam; 	Dyp-type peroxidase family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family of dye-decolourising peroxidases lack a typical heme-binding region.	20.40	20.40	20.40	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.00	0.70	-5.69	15	2768	2012-10-02 00:20:33	2003-04-07 12:59:11	7	7	1901	38	529	1917	88	307.60	30	85.21	CHANGED	QsGIloPhsssulalshslsutp.t......thh+phsutlstLptut................Dth.shtttt.sucLolslGhGsshac.....Rhuhs.pcPpcL+saschsssphpAssTsGDLhlaIpApct-lsFpsh+slhcphssslpVptchcGFph.........hssRsLhGFlDGTcNPpuscstct...sll......sscssshsGGSYVsVQ+ahHsl-sW-+lslp-QEslIGRcK.sssELstp....................stPssSHlsLss.c..-u.suhpILR+uhPauc.....sGph-tGLhFluYs+shcstct.lppMh.G...GssDtLh.-aopsloGuhFFsPsssph	.............................................................................................................................................................................QsGIhs......t....ptssha..lshslt..st............................thht.....hstthstL..ptut.h.............................-ph..hthhh.ssspLohsluhGsshac..............ph.uhs...t..t..........P....p....c.L.c..c....hs..t..a.ss.s..p.h.ps.........s.h.o.puDlhlpIpus.cpslsapshpslh..c..t..h.....s.s...h..l...pVc..chc.GFth...............................hssR..s..LhG..FhDG.......TtNP.....pup......pstph..........shl.....................t-t.........h.htGGSYhhVp....+hpap...lct.W....cR..............h........s....l..........c-.......Q..........E..............p.....h...hGR.sKp....s.st...lstp...........................................................hhPtsSHlphss........c...t..........p............s....p......s..........h.....p.........I......lR+uhsYus................................sut..h.-t..GLhFluYppshcph.h.lpshh................u.....p.tDtL.....c....a.sp.sl.s..GuhFFsPshs..h....................................	0	143	307	438
+329	PF02221	E1_DerP2_DerF2		ML domain	Bateman A, Yeats C	anon	Yeats C	Domain	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 (Swiss:Q15668) causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.33	0.71	-3.91	137	1034	2012-10-01 19:31:57	2003-04-07 12:59:11	10	11	326	68	586	1089	2	125.90	20	73.86	CHANGED	shshpsC...s.t.....sphpplsls........ss..hslhpGpsh.slshsh.ss.pp.spshps...plpsphss.......lplsh............csCc.........................pCPl.ptG.phhshphsh.s.........ls.p.hPss.....phplphplhsp.s.sp..tl..sChphsspl	.................................................s...hp.C.....st......hp.lpplsls..........ss....hslhcGpsh.s.....lphsh.ss......ppssps.h.ps..plpsphss.........lpl.sh.................shCc..............................shpC.....P.....l.ptG...ph...........s.hphsh.s........................l..p.hPss...........ph..plphplhsp.s...tp...pl....sChphsht................................	0	239	316	476
+330	PF03271	EB1		EB1-like C-terminal motif	Mifsud W	anon	Pfam-B_1529 (release 6.5)	Family	This motif is found at the C-terminus of proteins that are related to the EB1 protein.  The EB1 proteins contain an N-terminal CH domain Pfam:PF00307. The human EB1 protein was originally discovered as a protein interacting with the C-terminus of the APC protein. This interaction is often disrupted in colon cancer, due to deletions affecting the  APC C-terminus. Several EB1 orthologues are also included in this family.  The interaction between EB1 and APC has been shown to have a potent synergistic effect on microtubule polymerisation. Neither of EB1 or APC alone has this effect. It is thought that EB1 targets APC to the + ends of microtubules, where APC promotes microtubule polymerisation. This process is regulated by APC phosphorylation by Cdc2, which disrupts APC-EB1 binding. Human EB1 protein can functionally substitute for the yeast EB1 homologue Mal3. In addition, Mal3 can substitute for human EB1 in promoting microtubule polymerisation with APC.	21.10	21.10	21.10	21.50	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.18	0.72	-3.91	61	559	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	308	17	346	525	3	42.60	52	14.59	CHANGED	slEcERDFYFsKLR-IEllsQp..............ctppps..lh......................pcIpcILYu	.....LEKERD.FYFuK...LR-IEllCQc.p............-t-sss....ll......................pcIhcILYA.............	0	102	172	257
+331	PF05009	EBV-NA3	EBNA-3;	Epstein-Barr virus nuclear antigen 3 (EBNA-3)	Moxon SJ	anon	Pfam-B_4674 (release 7.6)	Family	This family contains EBNA-3A, -3B, and -3C which are latent infection nuclear proteins important for Epstein-Barr virus (EBV)-induced B-cell immortalisation and the immune response to EBV infection [1].	24.40	24.40	274.20	273.20	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.64	0.70	-5.13	11	121	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	6	5	0	56	0	235.00	84	38.12	CHANGED	MAlRQRlpDlRRsPhshcs...QR+W+LsSPupoW.MGYRTtolhhhoassstssss.lhLsAThGCpsGtRstsTFSAGsapPP+sust-QchhsspupVtplRppsscRY+hFFD.hlsltpSLptIWpslLps-.pRlsFhcFlGaLs+s-pshl+hWaccslGsh+sppPWhpssPst.sac..cslsscshstAah+GpshGlshLtssu.E.tcssssETssEpE......DsEs-u-D-..........plPpIlPp.t..shppRPslFlpR	..................................WPMGYRTATLRTLTPVPNRVGADSIMLTATFGCQNAARTLNTFSATVWTPPHAGPREQERYAREAEVRFLRGKWQRRYRRIYD.LIELCGSLHHIWQNLLQTEENLLDFVRFMGVMSSCNNPAVNYWFHKTIGNFKPYYPWN.APPNENPYHARRGIKEHVIQNAFRKAQlQGLSMLATGG.EPRGDATSETSSDEDTGRQGSDVELESSDD..........ELPYIDPNME..PVQQRPVMFVSR.	0	0	0	0
+332	PF00679	EFG_C		Elongation factor G C-terminus	Bateman A, Griffiths-Jones SR	anon	Pfam-B_40 (release 2.1)	Domain	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a  ferredoxin-like fold.	24.00	24.00	24.00	24.00	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.83	0.72	-4.12	172	18629	2012-10-02 20:07:24	2003-04-07 12:59:11	19	79	5330	69	5120	13346	6308	88.10	29	13.46	CHANGED	hlhEPlhplplpsP.....p-hhGslhsplsp.RRG.plhshpsp.........ss......tshlpsplPhsphh.satscL+ohTpGputhshpa..spYp.sssphhpph	......................lhEPhhplp..l...sP...................c-a.hGs.Vhst.ls....p.RRG..ph.hsMp.p...................ss........................................tstlp..hpl.PlsEhh..Ga...tscL+ShT...pGpu.s.h.s.hp.F..scYp.sshsh.t..h............................	0	1815	3287	4370
+333	PF03764	EFG_IV		Elongation factor G, domain IV	Bateman A, Griffiths-Jones SR	anon	Pfam-B_40 (release 2.1)	Domain	This domain is found in elongation factor G, elongation  factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.12	0.71	-4.54	81	9390	2012-10-03 01:04:38	2003-04-07 12:59:11	13	49	5414	57	2657	7106	2810	117.60	36	17.30	CHANGED	sp.Vua+E.hhpssc.tptphtcp.sGhcspau+hhlphcP..........ssuh.Fhstsp....GstlscEahsulppGhppuhppGsLusaPlhsl+lsLhDushHs..lcSoshsap.Auphuh+puhhpAp	....................................................................PpVuYREThp.pssc.hc....tpat+Q...o.GG....c.G.Q....a.u..clhlp..h...p.Php........................spGh....p.F.......s..plh...................GG....s...l.P...c......E...............a..lsuVpcG.l.p.p.uh.c......p.GlL....A..G....aP...........lh..Dl..+ssL.hDGuaHs............VDS..o..p...hAF.+hAuphAh+puhpcAt.....................................	0	986	1715	2277
+334	PF00036	EF-hand_1	efhand; EF_hand_1;	EF hand	Eddy SR	anon	Prosite	Domain	The EF-hands can be divided into two classes: signaling proteins and buffering/transport proteins.  The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site.  The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.44	0.74	-7.46	0.74	-4.24	893	3781	2012-10-02 16:17:27	2003-04-07 12:59:11	27	216	892	544	1838	18263	638	28.50	33	12.77	CHANGED	plcphapthDp-ssGtIshpEhtphhpph	...........lccsFphaDpDssGhIshpEhhphhp............	0	649	934	1356
+335	PF04189	Gcd10p	eIF3_gamma; 	Gcd10p family	Wood V, Finn RD, Bateman A	anon	Pfam-B_8933 (release 7.3);	Family	eIF-3 is a multi-subunit complex that stimulates translation initiation in vitro at several different steps. This family corresponds to the gamma subunit if eIF3 [1,2]. The Yeast protein Gcd10p has also been shown to be part of a complex with the methyltransferase Gcd14p that is involved in modifying tRNA [3].	21.00	21.00	22.70	22.80	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.77	0.70	-5.28	34	336	2009-09-13 16:20:58	2003-04-07 12:59:11	8	6	291	0	241	322	10	288.60	26	61.49	CHANGED	pshIp.spaVllc.hsu-thKlVclpsss....hlpLGKhGsF.lssllGhsaGpoFEIh.sp.................ph.h.l.psph.tpph.sp......................t.ttt......t.tpsscsN+sll.......Dsup.sQK..Lot--IppLKcp.stu...Gp-IIppllpsppoFcpKTtFSQ-KYl+RKccKahcha...Tl.h.ssshLsphahcc..-s.......t+lhclRt-oLuhlLshuNl+s..............sG+YLVhDc.TuGLlluAhhERMuu..........................................pGpllthapspt.sshs...hLchhs.....t..ts.p..pttlpslshhthhcs........ttpppppp.sshspc-hsshcss	...................................................................hIp.spaVll...h.sphh+.hh.p.lp..st....................plp.lGK.t.h.hspllGpsastoFE..lhspt............................................p.h.t.t...........................................................t.....................ptpp...s.spsNR.sll.......Dssp...sQp..Lot--IcpLKcp..uhs....................Gc-IIppLlpspsoFcpK.TtFSQpKYlp+KpKKYhp...hh..............plh..sssp.lsphahtc..-s..............s+lh.plR.h-oLu.lLshuNl+s....................................................................su+hLlh-s.suGLlsuAhhERhGu...................................................................................................pGsllphh....ss...s...sshs...hlphhs...hs.p...........p...t.......h....th.l.plp.h...p.......................................s........................................................................................................................	0	83	133	201
+336	PF03610	EIIA-man		PTS system fructose IIA component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.00	21.00	21.00	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.41	0.71	-4.02	36	8406	2012-10-02 12:41:15	2003-04-07 12:59:11	11	38	2718	39	912	3993	258	113.60	21	41.09	CHANGED	ulllsoHu.chApGlhchhphlhGc....sltslshhss..tshsshtppltpAl.pphsts-tllllsDlhuuss.stsst.hhcc.t..ht...hlsshslPhlhpuhsst...sphshsphhsplh	........................tlllsoHG.phApulhpssphl...h...Gp....t..p.lt.s.l...s..h.h..ss..........p.ssssh...hpcl.pptl.....p..p..h....s....s....sc......s.lllLsDlhu.u.o.shst...ss..p...h...h...h..c...t.p......hp.............llsGhNlPhll...pshhtp.....tths.h.tt.ht...h.......................................................	0	255	550	740
+337	PF01448	ELM2		ELM2 domain	Bateman A	anon	Bateman A	Family	The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex [1]. The domain is usually found to the N terminus of a myb-like DNA binding domain Pfam:PF00249. ELM2 is also found associated with an ARID DNA binding domain Pfam:PF01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.86	0.72	-3.32	53	960	2009-01-15 18:05:59	2003-04-07 12:59:11	19	46	123	0	518	897	2	55.30	31	7.90	CHANGED	IpVGsc.aQ.....AcIPphtspspppppppt.........................ccpl...lWsP.........s....tlsc...ppl-p.......alp.hupspt	.............IpVGsp.aQ...........A.-..IP-.hhsps...ptspcp...pp...............................................................................tcpL......VWsP.........p...sls-.......pcl-p...aLs.hApp..s......................................................	0	109	160	306
+338	PF02990	EMP70		Endomembrane protein 70	Griffiths-Jones SR	anon	Pfam-B_1312 (release 6.4)	Family	\N	22.80	22.80	22.90	23.10	21.20	22.70	hmmbuild  -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.91	0.70	-6.04	15	1526	2009-01-15 18:05:59	2003-04-07 12:59:11	11	27	425	0	910	1437	39	423.80	34	82.92	CHANGED	hsYcYYs..LsFCpPpp..lpcpsEsLG..EVLpGDRlhsSPaclchhccppCpslCpp.......plspccschlpctIppsYahpallDs.LPlsspltphcs...........h.h..Gah.s.p.......................................pspKhYlaNHlchhlpYH....cc.........RllslpVpshSlc...............p...........ppP.hlcEsp-.......lhFTYSVcWpcoc.lcWuo...RWDtYLc......hpshpIHWFSIlNShllVlFLoGlVuhIlhRTL+pDlu+YNp.-ptp.............DspEEsGWKLVHGDVFRsPp....pshLLSsllGoGsQlhhMlhsslhFAhlGhLuPusRGuLhTshlllYslhGhluGYsSuplY+phcGp..................pWKpshlLTuhLhPGslFshhhlLNhllWupsSSuAlPFuThlhllslWhhlSlPLohlGullGh......Rppsh..csPsRTNpIPRpIPp..QsWYhpslhuhLhuGlLPFGuIaIELaFIaoSlWtpc..hYYhFGFLFlVFlILllssuploIllTYFpL..CuED....Y+WWWRSFlsuG.uoulYlFlYSlaYahsKhp.lsGhh	...........................................................................................................................sYpYat..hs.a.Cts....t..........................t................................t..........sLG..p............lL...Gccl....o..a.p.....hp..h....p......p....p..t.....hh..Cp....................t.h..s.t.t.p.hp.ht.phlppt.Y.hphh.....................l.Ds.LPhhh..h....h....tt................................................................................................t.tt.p.h.h.l.sHhph.......l..ap..................t.p..........................................................pllt.hpl.s.......t........................................................................t.......l.t....t..tt...........l.aoYsVt.a.p..sp....hta..ts..............R.aD..h..ah.t.......................p.plHWh.....................SlhNSh..h....h.VhhLs..........u.h.l..shI.h.hRs.L.+.pDhs..pYs.p..pt.t...............................................t..t-....-.GW.K.llHGDV.FRs.Pp.........t.shlLsshlGsGsQlh...hhshhsl...h.h.......Ahl............G...........h.........ls......PspRGu.l.hT...shlhlashhu.hh.uGYsuu..p......h...Y+ph....t...Gp..........................................pWh..pshh....hT.uh..lh...Pu..hlFsh.hh.hl...Nhhhhs.......t...S...ouAl..PFsThl.s.llhlW.hhlslPLshlGuhhG..........................+p.sh...p.Ps......+..s.....s.pI.PR...p......I......P............p........a....ah........p.....s.........h..h....l..hu..GlLPF..u..sl....alE...L....a.FI.h...............s.S...l..W..pp.....hYa...ha..G................FLh.ls..h..h.........l....L....h.lssu.plo.l.lhs.Y.h.L........s.sE.s..................a.pW.Wpuahsuu.ssu.halhh..YuhhY...hh..c.p.h.t..h.........................................	1	327	520	748
+339	PF01223	Endonuclease_NS	Endonuclease; 	DNA/RNA non-specific endonuclease	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.68	0.70	-4.70	59	2367	2012-10-05 18:28:12	2003-04-07 12:59:11	18	35	1457	25	866	2278	269	199.70	19	53.76	CHANGED	hhptaslsaspp..pchshasttplsssshttspsp.....................................spat.-.slsst.hpst.ssatsth.......aDRGHlss.......sspthspss.psTFhh.sNhsPQ.htshNp..ss.........WttlEshsRphsp...............ptpslhlhoGshhh.s.........................................................ttlslPphhaKllh..ts.t.................htuhlhspts..pth...............tt.............h.hsl.tl.t.......sG..lsahsslsst	.........................................................................................................................................h....as.sastp.....pchs.asu.p...l.pt..ps.htttptp................................................................................ttspa....t....-..s...pl..s....t......t.....h....p..s.t...ss...Ypt.su......................hDRG.Hhss...............sshph...u..p.ps.psoF.hh....oNhsPQ..t....t......shNp.....sh.................W......s.t.l.E.p.h.l.R.p...h...s.p....................................ph.p.slhVhoGslhh.p.........................................................................h.h.t.tspl....lP...phaaKllh.s.pttt....................................h.uahh.pt.....t.........................................................................h.httlpt.......................ss....hphh......t..........................................................................................................................	0	233	407	665
+340	PF00812	Ephrin		Ephrin	Bateman A	anon	Pfam-B_1390 (release 2.1)	Family	\N	25.00	25.00	25.20	25.70	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.06	0.71	-4.70	14	554	2012-10-02 17:41:00	2003-04-07 12:59:11	12	4	91	31	288	430	1	131.80	39	52.16	CHANGED	tsuuscasVYWNSoNs+Fhp.pshsltlpIsDhLDIlCP+hEss..........spshEhYhLYMVsh-thcsCph.tpcsphhhpCs+Pps.......................sPl+FopKFQcFoPhshGhEF+tG+-YYYISosssshtsp.......ChphphpVhh+sup	..............................h.......h.Ws.s..t..N..+...............Fh......t...t............sh.sl...tlp.l.s......DhLDIhCP+hcss.........sttphE..hYh.LY...............hV.s.t-tacsCph...p...pp..s.h.hhhp.Cs+Ppt........................slKFo.KFQcFoP.s..hGhEF+sG+-YYaISosssst...tth.........C...hphp.hhlhhps.................................	0	47	74	164
+341	PF05139	Erythro_esteras		Erythromycin esterase	Bateman A	anon	COG2312	Family	This family includes erythromycin esterase enzymes [1,2] that confer resistance to the erythromycin antibiotic.	26.30	26.30	26.80	26.80	25.40	26.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.09	0.70	-5.25	73	695	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	516	4	246	666	50	310.70	22	67.58	CHANGED	slAlEuDWPDAhpls+YVpst.ss..................sspt............tsapRFPtWMW.RNpEhhchlcWLRsaNsshs.....tpc+...lsFaGlDlY....ShtsShpsVlp...YLcpsDPptA.......ptA+ppYushs.h.sccsttYGhtsh....t..hpssccpllppLpcLhppthphttp...ts....-chh.ApQNAplltsAEpYY.....+sMhtstsps.......WNlRDpHMs-oLptLhcph..stp.....uKslVWAHNoHlGcApuTphu.........ts.hslGQll+-paGcc.shhlGhsohpGsVsAuspW......ssshphhplpPuhssSaEplhcpsuhspallch...........ssthtphL..tp...RhpRuIG.VlYpPco..Eh.SaYhpssLscQFDullah-cT	.....................................................................................................................luhEssassuh.t.l.scYlpst.ts..............................s.p....................hppa...th..ha..psp-hhshl.cWhRpaNtp..............ttpp....lthhG.hDl...........s.tp.s..h.p.t.lhp.......Yl.c.p.h.s...sphh...............ttscpt.h..tth....p....h...tppsthh.sh................htppppphhpthpclhphhtp..ttt....s.................cphhhs.ppsAphltphtphh.................pshht.s..s.pp.....................hsh.....RD.ptM.h-slthlhcph......t.......................u+hlVWAHNuH..l.ucspss.hh.................................t.hshGphlpc.p.hGcp....hhslGhsshpGphsshpt.........st.hthhtlts.s..ssShE.t.h..h.t.p...s...s....h......s......t.hhlsh................pt.ht.thl..tt...t..hhh.....G....shhhst..........hhh....ht...ptaDshlahpp........................................................................	0	83	170	220
+342	PF04800	ETC_C1_NDUFA4	ETC_CI_21; 	ETC complex I subunit conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6275 (release 7.5)	Family	Family of pankaryotic NADH-ubiquinone oxidoreductase subunits (EC:1.6.5.3) (EC:1.6.99.3) from complex I of the electron transport chain initially identified in Neurospora crassa as a 21 kDa protein [1].	25.00	25.00	25.10	26.80	20.80	24.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.35	0.72	-4.15	6	625	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	542	2	330	566	1035	98.40	40	65.94	CHANGED	RpsRIYpPA+sshQSGpu+spcWpl-F-.spt...RWENPLMGWooouDPlup...hcLoFsT+E-AluFAE+pGapYpVcEPps.+hKsKuYusN.......Fuas++pp..h	...............psRIYpP.A+.sAMQ..SG..p.s....pT.......c......p.......Whl-a-....ppt....R.h..sPLMGWsSS......uDshsp.......lpL..pFso+E-AluaAc+pGhsY.pVp.E..Pp.............p...............p....h..+.......+...u...Yus..N.......Ftas+.t.h..p.......................	0	107	195	261
+343	PF04716	ETC_C1_NDUFA5	ETC_CI_29_9;	ETC complex I subunit conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4159 (release 7.5)	Family	Family of eukaryotic NADH-ubiquinone oxidoreductase subunits (EC:1.6.5.3) (EC:1.6.99.3) from complex I of the electron transport chain initially identified in Neurospora crassa as a 29.9 kDa protein. The conserved region is found at the N-terminus of the member proteins [1].	20.10	20.10	20.20	21.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.69	0.72	-4.44	32	283	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	238	0	190	282	2	58.80	37	34.55	CHANGED	ssP+tsLhsLYschLcpLp.phPcsusYRptTEtlsppRLplVcp......ppshcclEpp...lss	....sP+psLhhLYschLctLp..phPcsu.sYRptTEtlTpcRLslVcp..............-tslpclEcpls......................................	0	66	104	156
+344	PF04621	ETS_PEA3_N		PEA3 subfamily ETS-domain transcription factor N terminal domain	Kerrison ND	anon	DOMO:DM04577;	Family	The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding [1]. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades.  The N terminal region contains conserved MAP kinase phosphorylation sites [2].	30.00	30.00	30.10	30.10	28.10	29.90	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.48	0.70	-5.21	10	264	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	49	0	96	260	0	269.80	47	68.50	CHANGED	MDGFYD...QQVPFhVss.sppu...ppstsRsss-RKRKF.lso-LAp.......DoEELFQDLSQLQEtWLAE......AQVPD.DEQFVPDFQS-N.LhFHGPP.sKIK+E.pSPup-h.SsCSpcps.shsaGEKCLYsh..........................SAaDpKPssuhKPsoPsoTPsSPhss.sth....uotPhpcsosss...........................hthPh.sps.P.hls.Ps.s..sssass-pR.......FpRQLSEPChsFPs.suth................s+-sRPsYaRQMSEPhlPh...PPQGFKQEhhDPlYscpGhPs............stsap.....tshsIKQEPRDFsaDSEVPsCpSsYh+ssuF...sstp-..Gata-+-s+hFaDDoCVVPERhEGclKQE.suhaREGPPYQRRG	........................................uhhDQp.V....Pah.st..pp.s.....tt.ttt....h.sp.t+hh...sp.......s...............DSE........-LFQDLSQhQEsWLAE...................A.Q.VPD..DEQFVPD.apu-s.......L..................sFHu.P.hKIK+E.pSPso-..puCSpcps.h.hsaGEpCLYs......................................sAY-p.p..suh+s.sPssss......oP...................h..hpttu..s...................................................................................Ph.....spt.................h..s....c.pp.......................................a.p.Q.sEs.CpsFss..s................................sttsts.YpRQhSEP....hPh...P.QuFKQEYhDPlYEp..t.shsu...............................s.stp........sshhIKQEPpDasaD...S..-...VPsC.t.......S.Yh+tt.sF.......st.pt.........Gh.a-Ks.R..a.DDsCVVP.E+h.-.G.clKQE.ssha..REGPsYQRRG...................................................................................................	0	7	15	38
+345	PF04777	Evr1_Alr		Erv1 / Alr family	Finn RD	anon	Pfam-B_5005 (release 7.6)	Family	Biogenesis of Fe/S clusters involves a number of essential mitochondrial  proteins. Erv1p of Saccharomyces cerevisiae mitochondria is  required for the maturation of Fe/S proteins in the cytosol. The ALR  (augmenter of liver regeneration) represents a mammalian orthologue of yeast Erv1p. Both Erv1p and full-length ALR are located in the  mitochondrial intermembrane an d it thought to operate downstream of  the mitochondrial ABC transporter [1].  	25.60	25.60	25.90	25.80	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.63	0.72	-4.09	59	881	2009-09-10 22:39:07	2003-04-07 12:59:11	8	18	378	43	544	854	401	96.80	29	29.08	CHANGED	puhWshLHshuupaP..pp...Potpp..........pp...shpsahphhsphaPC.ppCupcFpphht....p..tssp.............lso+cshstWLhphHN..pVNp+LuKs...................s..sph.pppats	..................................puhWp.lhHohssp.as....cp.......Po..tpp....................pp...shpshhphh.sph.aP.C..p.............cCupc..Fp.phhp............c......p.sp.............................lp.o.ppshshWlhphHN..pVNp+LuKs...................ps.sph.p.pa..s.............................	0	190	296	442
+346	PF03372	Exo_endo_phos		Endonuclease/Exonuclease/phosphatase family	Dlakic M	anon	Dlakic M	Domain	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.30	0.70	-4.44	326	20400	2012-10-02 01:25:08	2003-04-07 12:59:11	18	388	4759	145	7593	17817	4636	258.00	13	59.21	CHANGED	h..oa..Nlpt....................................................................................ltp.........hlppts.................sD..lls.....................lp....Esp............................................t.h...tthhtt.......hs...tt.h........................................shslhs+h................s..httthhthh............................................sttththhhthtttth...............................................................lh...ssH..............................................hss................tstttp...t.phhpth........tthhtt................................................hllhG.DhN...........................................................................................tshh....stth......pshpthh...h.................................................................................tl........Dalhs.............htththtththht...........................................SD..H	................................................................................................................................................................................oaNlts....................................................................................................lhp.....................hl......p.p.s................................sD......lls.....................LQ..........Esp..............................................................................................................................................................................................p.h........tthht.h.......................h..................h.............................................................................................................G.lu.l...h.s...+.h.................................................................h..t..h..h.t.thh............................................................................................................................................................................stt.t.h.h..............h..h.h..h.t..t.........................................................................tt.tlh........lh......ssH........................................................................................hss......................................ttpttp............ht......thh.phh......................p.phh.ptt.............................................................................................................llls.G..Dh.N.........................................................................................................................................................................................................................................phh................p.t.h......................p.h.h.p.t.h...h..t................................................t..h...shtht..................t..h...............................................................pl...............D.alhh......................................................thh.h.t.t...........................................................SDH.............................................................................................................................................................................................................................................................................................................................	0	2415	4456	6161
+347	PF02609	Exonuc_VII_S		Exonuclease VII small subunit	Bashton M, Bateman A	anon	COG1722	Family	This family consist of exonuclease VII, small subunit EC:3.1.11.6 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones [1].	20.80	20.80	20.80	21.30	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.35	0.72	-4.19	148	4033	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	3983	6	847	2207	1003	52.90	37	66.86	CHANGED	FEculpcLEpIVpcLEsGclsLE-ulchaccGhpLhcpCpptLppAEp+lphl	..................FEculp-LEpIVpcL.E.s.G.-ls.LE-ulshac+GhpLs+pspppLppAEp+lphl...........	0	283	566	723
+348	PF00929	RNase_T	Exonuclease; Exonuc_X-T;	Exonuclease	Bateman A	anon	Pfam-B_1153 (release 3.0)	Family	This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III.; 	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.07	0.71	-3.96	57	17634	2012-10-03 01:22:09	2003-04-07 12:59:11	19	169	4800	65	4662	12914	5053	160.30	21	36.06	CHANGED	lslDsEsTGhss..............hspllEluslplsstt...........htt.hphalpPpp...lsshsschsGIosth..lpstsph.p..shpthpphhp.t........phhlsps..hsh.hshhhpp.hchhhh.h......ht.hhcththspthhtthtt...........sLstlspphthpt.pp.......HpAlpDsptshplh	............................................................................lhlDhE.T.T.Ghss...........................ttsc.ll...-..l.u.s....l..pl..pssp.............................hssphp.h..h...l...p..P..p......p..........................l.....s....s..h...sh...p....l....p.....G................Io....s...ph.............l..p..s...t..s...s.......htp.......shp.p....h.h.p.....h...l....p.....s...........................................th..hVu.....+......N.....s......s.....FD.....hs.hh..t.t.p.h..t..c..h.h.h.h...hs.........................p.s.h...h..c.s...h..p....l...s..p....t.....h......h....thtp................................hpL.s.p.l.sp...t...h....s..l...p.h.ppt.....................H.p.AltDsptospl...............................................................................	0	1427	2706	3817
+349	PF03016	Exostosin		Exostosin family	Mifsud W	anon	Pfam-B_2031 (release 6.4)	Family	The EXT family is a family of tumour suppressor genes.  Mutations of EXT1 Swiss:Q16394 on 8q24.1, EXT2 Swiss:Q93063 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia.  EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities [1]. The nature of the defect in heparan sulphate biosynthesis in HME is unclear.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.97	0.70	-5.38	33	1543	2010-01-08 15:44:36	2003-04-07 12:59:11	10	45	197	0	1043	1489	205	267.00	21	51.06	CHANGED	tpsshpVYlYcls......................................................pshh.sppash-hhlhpplppsp........hhstcPscAslFalPhhsshp.......................pphh.t.l.phhpph..shW....pc.tGcD...Hllsssps......................ssthhh...thtspshhsl....h..s...................ptphh.spD...lslPshhpssshssthst.........tpRphLhhFsGshtht..t.................ttslRstllcph..........ts..sst.t.......................tptppts..p..........hhchhpsupFCLh.PtGt.p......sptplh-ulhuGClPVll.uc.......shp.....LPFtshl.DapchoVhlscpcl......splhphLcsl	...............................................................................................................................................................h....hhlalY.........................................................................................................................pt......ht.......t..hh.hhttl......pst..................................hhstssppAshahl..s...h..sh.........................................................t.t........h.......t.l.....t....h....h....t....ph............sh.W......................pc......Gts......Hh..hhshts.............................................................t..........thh..shhsh.................t..........................................................................ptthh.thD.......lshP..h.....h..........ts....t....h........................p.......R..ph.L.h..h.F..tG.t....h...................................................................ttth+.h...lhp.p..h.....................ps....tt...p.......................................ht.t.t..t...p...............................hhphh..tpS.....pFCLh...Pt.Gt...p..................ss.Rlh-ulh.sGC..lP....Vll..uc......................ph......LPa....t...p.hl....sapphu...lhlsppcl..............pl.phLpt................................................................................	0	337	682	871
+351	PF03124	EXS		EXS family	Mifsud W	anon	Pfam-B_605 (release 6.5)	Family	We have named this region the EXS family after (ERD1, XPR1, and SYG1). This family includes C-terminus portions from the SYG1 G-protein associated signal transduction protein from Saccharomyces cerevisiae, and sequences that are thought to be murine leukaemia virus (MLV)  receptors (XPR1). N-terminus portions from these proteins are aligned in the SPX  Pfam:PF03105 family. The previously noted similarity between SYG1 and MLV receptors over their whole sequences [1] is thus borne out in Pfam:PF03105 and this family. While the N-termini aligned in Pfam:PF03105 are thought to be involved in signal transduction, the role of the C-terminus sequences aligned in this family is not known. This region of similarity contains several predicted transmembrane helices. This family also includes the ERD1 (ERD: ER retention  defective) yeast proteins Swiss:P16151.  ERD1 proteins are involved in the localisation of endogenous endoplasmic reticulum (ER) proteins. erd1 null mutants secrete such proteins even though they possess the C-terminal HDEL ER lumen localisation label sequence. In addition, null mutants also exhibit defects in the Golgi-dependent processing of several glycoproteins, which led to the suggestion that the sorting of luminal ER proteins actually occurs in the Golgi, with subsequent return of these proteins to the ER via  `salvage' vesicles [2].	25.00	25.00	26.30	25.10	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.26	0.70	-5.42	68	815	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	326	0	551	823	12	287.00	27	50.36	CHANGED	hhh.lapshhLlllhhahaulslahWpptplNa..s....hIhchs..........................ppplshpphhp.............lushhs.................................hhhslshhhhhhh.h.t...p.hth.................PhhhlhlhhhlllhPh....phh........htpuRhahlpslhRllhush....h.VpFsD..FaLuDtLsShshsltDlthhhChah..h.h.............ptt..............stCtpsphhh............sllsslPshhRhhQClRR.ah-spct...............sHLhNAhKYssshhshhhtsh..hchppspt.......................hhhhalhsuhlsShYshhWDlhhDWuL.........................hpps.t.s....................................cshhLR..ccLha.............sp.......hhYYhAhlhsllLRhsWhhp..hh.................pht.hh..pp....plhshl...luhlElhRRhlWsFFRlENEHls	..................................................................sh..hath.hhhh.hhhhhshsh..h.hap..t..tl...sa..s......hlhphp...............................................tpthp.tphh...............................................hsshhh..........................................................hhhh.h.hhh.hh...............................................Phhhh..hhhhh.....hlh.Ph....thh.....................................hpsRhhhhhhh................hRlh.hush............h.ltFtD..haluD.lsSh......s......h..........sh...hsh..thhhChahh..........................................................t.C....t.t.hh..............................hl.slP...hhRhh.QClRc...ahc.s.tph..........................aLhNuhKYssshhhh....hhtsh....hph........t.t..t............................hhhhalhhshlsohYshhWDlhhDWuL..........................hp......s..................................................................................................................pthhLR......cplhh.................................p........h.hYYhuh...l.sllLRhsWhhp.h.h...................ph..h.....ps....phhs.hh...huhlElhR.RhhWsaaRlEsEal.............................................	0	185	336	476
+352	PF04554	Extensin_2		Extensin-like region	Bateman A	anon	Pfam-B_1707 (release 7.5)	Family	\N	20.80	20.80	21.10	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-11.10	0.72	-4.10	14	490	2009-01-15 18:05:59	2003-04-07 12:59:11	8	22	25	0	352	530	3	49.70	73	84.32	CHANGED	YcYpS.PPPP.hp........PPPP...Ya.......Y+SPPPP...s....YhYpS.PPP..Pha..........SPPPP.........YhYpSPPPP	................YlYsS.P.PPPhYp......Po..P+..spYKSPPPP.........Y...VYuS.PPP.......PhY.........SPSPp.........spYKSPPPP......................	0	227	309	310
+353	PF00646	F-box		F-box domain	Bateman A	anon	Prosite	Domain	This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; Pfam:PF00560 and Pfam:PF07723) and the WD repeat (Pfam:PF00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression [3].	20.50	15.60	20.50	15.60	20.40	15.50	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.28	0.72	-4.22	463	9939	2012-10-02 00:56:31	2003-04-07 12:59:11	28	388	416	10	7006	15392	101	45.20	20	10.27	CHANGED	htl.pLPtc........................llppllpplshts.........hhphphls+phcphlpphphhtptht	...........................................................................h.pLPt-..........................................................lltcIl.p..p.L..s.hps..............................lh.p.hp..tls+pac.plhpp.........hh........................	0	1706	3015	5562
+354	PF00754	F5_F8_type_C		F5/8 type C domain	Bateman A, Finn RD	anon	Pfam-B_478 (release 2.1)	Domain	This domain is also known as the discoidin (DS) domain family [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.67	0.71	-4.31	185	10300	2012-10-03 19:46:52	2003-04-07 12:59:11	20	1197	1614	169	3934	9293	615	125.60	16	18.56	CHANGED	phsuSo..phssth............stttlD...ss............t.stWps....t.......sssspalpl..DL.spstplsslhhpst..psttt...........hspsaplphS..sDG.....p.........sWpphtt................ss.ssss.hh..........hh.sshpu.....RalRlhsh...........h.stsphsthhEl	.....................................................................s.....t.................tttl.D....us............................s.s..t..W.ps......t.........................sstspa.l..pl.................D.........L....s...p.......p.....p....l.s..t.l..t...h...p...sp....tsttt........................hspsa..p.l.t..hS........s..cu.........p..................sW.pphtp.........................................ss..s..s..s.s..hh........................................hh....t.s.h.p.u..............+a..l..Rlh.h................tt....h.............................................................................................	0	2052	2661	3306
+355	PF00487	FA_desaturase		Fatty acid desaturase	Finn RD, Bateman A	anon	Bateman A	Domain	\N	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.16	0.70	-4.94	127	9036	2009-01-15 18:05:59	2003-04-07 12:59:11	19	46	2567	0	3138	8639	3621	228.30	15	66.62	CHANGED	hs.hhhhhhhhhhhshhhthhhhltH-ssHt.....thhtpphhsphhuthhshh....hhhshht.a...p.......Hhh.HH......phhss.t........Dssthhh..............................hhhhtphhhhhhhthhhhhhhhhhthtttthhttthh........................................hhhhhhhshhhhhhhh.hhhhhhht..................shhhhhhshhhhhhhhhhhs...........h.t..Hhhh...........tttttstshhtpp....hh............hhshhhhs..hs.aHh..................tHHh...aP...sls....ahpLsphttthtphhtttthshhtht	...................................................................................................hh.h.h.h.h..h.h..h..h.hh.t...hhh..hh.tHphuHt......................th....t..p....t.....h..h..p..p..h.h..u.h.h..hhhh.........................h.sshht..a...thp...........................Hpt.HH......................phsss.t...............Dss.shh............................................................................t...t..h....h..h.....t..h..h.h...h....h......h...h..h....h...h..h..h..h......h.....t...h..t..h....t.p....h..t..phtt................................................................h...h.hh.hhh.hh..h...h....s.h..h...hh........hh...h...h.........h...h...t........................................................hh...h..h....h..h....l.......t..h..h.....h...h.t.h.h.h.hhs.........................ht.......Hhh.............................h.tpttpthhp.pt................h...........................t..h.h.h....s..h..h.hh..s........hs..hHs...................H...Hh..........aP............th........h..h........................t...........................................................................................................	0	1025	1826	2610
+356	PF02913	FAD-oxidase_C		FAD linked oxidases, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	This domain has a ferredoxin-like fold.	21.20	13.90	21.20	13.90	21.10	13.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.30	0.70	-5.06	62	9445	2012-10-02 00:48:38	2003-04-07 12:59:11	14	65	3272	53	2996	8280	3740	227.50	22	39.33	CHANGED	hPpttssshshasshpsAs..psstplhpp.thhssshEhhDptshphshshhsh.........................tt.shlllchpusp...th.tpphp..tltphhptsssss................hhsps.tphp..plWp...hR+thhs.............hhhpttshsht.DsslPhsclsshlpphcphhsphs..........hhhshhuHsG.......DGNlHhhlhhs.ts......tthcphpphhtcl....hthshphGGolouEHGlGht+pt....ahttthuttslshh+plKpshDPpsILNPG+l	.......................................................................................................................................................................Pt.ttshhhta..s..s.......hpsAh.....psl...t.h....h....t..........t.....t.............h..s....s..u..hE......hhDph....s.l.p..hs.pph.hth......................................................h.p.t..t.s..h.ll.lE...h.s...G.s.s.............t..t.h.....p.........p.......p........hp................hltph.hp..p.t.s..s.t.p............................................h.......hsps.tptp.........plWt.........hRcpshs..........................................h...t...p...h...t...s..hhh.t..p...Ds..slPh..spl.sphlpp..h.pthhp.phs...............................................ht.h.s..hhuHsG.............DGN..l.Hh..h..l..h....h...s..h..s..p......................tp..h..p..p.h....c..t..h.h.p.cl...........hp.h.s.h.c.h.G.Go.l....o...u.EHG..lGht+.t.........hh.h........h..u..ttt.......h.thh.ctlKtshDPpslhNPGK.........................................................................	0	916	1869	2506
+357	PF01565	FAD_binding_4		FAD binding domain 	Bashton M, Bateman A	anon	Pfam-B_352 (release 4.0)	Domain	This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110 [1]. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyses the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyses the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158.  This enzyme is involved in the biosynthesis of peptidoglycan [2].	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.52	0.71	-4.70	142	20637	2012-10-02 01:00:47	2003-04-07 12:59:11	18	164	4917	139	7390	17693	6472	133.60	21	26.34	CHANGED	P.thllhPpotp-ltphlchup..pp...shs..lhshGuGsshs.uts..........psu...lllsh.t..p.hsp..lhpl-s....t...stpsplpuGshhtpltptlttp..uhhhs.p.sush.ss..olGGhlsssusGhtstta.G.hh..-hlhulcllh.ssGpllphu	.........................................................hllhPpsh.p-ltth..........l....ph.st.............pp..................p..h.s.........l..h...s...h.G.u.G........o.s...hh..utsh.................tsu.................ll..l.sh..p...........p..hsp...........l..h.p...l..c...............................t...........s..t..h..l..p...l..p..u.....G.s.h.h.t..p............l.t.p..t.........h......t........t....p...........u...h..h..h......s................p....s............u....s...t....................s............s........o........l.G...G.s...l..s.s...........s...u...u.......G...h..t..........s...h.........t..........h...G.....hh......-h..lhs.l....cl..lh..ss..Gplhph.................................................................	0	2058	4492	6188
+358	PF00970	FAD_binding_6	Cyt_reductase; 	Oxidoreductase FAD-binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_143 (release 3.0)	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.35	0.72	-3.87	115	14779	2012-10-03 00:38:56	2003-04-07 12:59:11	19	159	4278	144	4286	11998	1730	96.10	21	26.84	CHANGED	tspLls+pplScDs+hF+F.tL..s.sssph...luL..PsGpalhlpss...ls.sc.hhRuYoPsSss..s..-hGh..h-LllKlY.........sGGtMSp.aL.-s.L.plGsh.lcl+GPhGp.htY	...............................................................................lhphp...s..t..s..h.h..h.....hp..h..th...........s....t..........t....t..........h..t.a......p.s.G....Q...a......l..t.........l...t...l...........t.................p.......s............p.........................h........h............R.s....Y.........S........h......s.................s.......s................s........s.............pp.s...t...............lc......l..tl...+t.h............................s..G.h....h..S..s....h...L....p.....p.....l.....p.......s...G.......D.....p......l.p....l.t.s....PhGp.h..h...................................................	1	1115	2425	3487
+359	PF03441	FAD_binding_7		FAD binding domain of DNA photolyase	Griffiths-Jones SR	anon	SCOP	Domain	\N	20.10	20.10	20.10	20.10	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.86	0.70	-5.19	163	4493	2009-09-11 23:21:46	2003-04-07 12:59:11	9	22	2644	55	1440	3950	7444	245.00	30	51.07	CHANGED	sGEps..AhppL....psFl..p..p..plpsYpps..Rsh.P......ut.....s.........................................uoSpLSPaLpaGplSsRplhptspptt...........................shpsalpcL.hWR-a.hhphhhptPpht.....................t.shppta.ps.h...Wt..................ts.p...tthpsWppGcTGaPllDAuMRpLhpTGa..hHNRhRhhsuSFLsK.cLhl-WctGtc.....................aF...........hppLlDh-.usN.ssWQa.uu.sGhss...hRlaNPhpQuc+aDPsGpal+pWlPELtslssc.hl..Hp...........................Paphst......................s.......YPp.P..ll-hppsRctslctatphp	......................................................................................ucptAhppL.....ppFh.p............ptl.t.pY.ppt..Rsh...s.......sh....s..........................................uo....Sp....LSsaLt............h...G..tlS.sR..phhpplhpttt.......t................................................tsspsa.lpcL..hWR.EF.ah.tl.h.h.t.h.P.p.h.t............................................................................p.ts...h.ps..t..h..pp..h......W........................................s..tthpt..W...p.p...GcTGaPll.D.Au.....MRp.LhpTG.a..hHNRhR.h...h........s.A.oFLsK..cLh..l...cW.c...G..t..c.....................aF.......................hppLlD.h....Dh...us...N......ssW....Q......ahuu....s...G..............s..D....s.........h..............h....R.h.aNP..............h..t.Q.........u.c.+a.....DspGp..a...l..+.p.....al.PpL.tt...lss......p......l.ap.............................................sht...........................................................t..............YP..s..hl.phtttp...hthh....t...................................................................................................	0	488	923	1231
+360	PF03101	FAR1		FAR1 DNA-binding domain	Mifsud W, Bateman A	anon	Pfam-B_2535 (release 6.4)	Domain	This domain contains a WRKY like fold and is therefore most likely a zinc binding DNA-binding domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.27	0.72	-3.46	43	1076	2012-10-02 23:28:20	2003-04-07 12:59:11	10	54	116	0	699	1040	0	87.40	24	15.96	CHANGED	pFYspYAtpsGFulRhsppp+o...ptss.hhpppFsCs+pGhppppppp.............................ptpp.....sps.oRsGCcAtltl+hpp...sucWhVsphs.....h-HNHtLss	.....................................................aYptYAtphGFsl+hpp.s..p.ps........ts.t..t..hh..ppp..a.s...C..s..+pGhppppptp.....................................................t..pp............pspsR.suC..pA.h.h.t.l..p...hpt.........ss......p..W...hl....p.p.h...........hcHNH.l.............................................	0	82	399	567
+361	PF04300	FBA		F-box associated region	Bateman A	anon	Bateman A	Family	Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Swiss:Q9UK22 is involved in binding to N-glycosylated proteins.	25.00	25.00	27.50	25.90	21.50	23.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.36	0.71	-4.32	6	396	2012-10-03 19:46:52	2003-04-07 12:59:11	8	16	84	7	192	352	2	158.30	36	59.10	CHANGED	WKshYhhpshcRNLLRNPCu.............................EtshpuWp.lp.pGGDtWpVEpLPhssusphP.sstVpphFloSFcWCpKpQhVDLcAEGhW-ELLDoFpP-IVVcDWausRtDsGChYpLcVpLLuAD.psVLspFossPssh.Qhss.ssWpcVSHsFScYsPGVRalpFpHtGpDTQFWsGaaGsRVTNSSVlVcs	.................................................................p.hh...h...hp.htRNLl+NP...su...........................................................................-.p.sh..phWp...lp..pG..G..s.tWtlEp....t.......p....t....t.hs...s...........tl..........p....ph.Fl.o.S.athChKp.Qll....DL.tEG.h....htclh.DphpPcIh...lpDW.as.s...Rt..ssus.h.Yp.lpVpLL...........stp...p.....ps.............l..............sp..........F...............p......ss..........................h...h.ph.ss.......tt....WpploHsFpsYs.sGVRalhFpHtGp..Dsp.aWtGaaGs+lTsSSl.l..h..........................	0	32	57	98
+362	PF00611	FCH		Fes/CIP4, and EFC/F-BAR homology domain	Ponting C, Schultz J, Bork P	anon	SMART	Family	Alignment extended from [1]. Highly alpha-helical.  The cytosolic endocytic adaptor proteins in fungi carry this domain at the N-terminus; several of these have been referred to as muniscin proteins [2]. These N-terminal BAR, N-BAR, and EFC/F-BAR domains are found in proteins that regulate membrane trafficking events by inducing membrane tubulation. The domain dimerises into a curved structure that binds to liposomes and either senses or induces the curvature of the membrane bilayer to cause biophysical changes to the shape of the bilayer; it also thereby recruits other trafficking factors, such as the GTPase dynamin. Most EFC/F-BAR domain-family members localise to actin-rich structures [3].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.07	0.72	-3.80	157	2299	2009-11-12 14:53:54	2003-04-07 12:59:11	18	60	270	55	1342	2138	1	91.60	21	13.78	CHANGED	psFhsph.........tuhcslhp+hcpuhphh.c-ltpah.+cRuplEccYuppLp.clspchhptht.........ttpp......uol.................ppuapplhspscphuptHtphuppl	..............................hhtth.............tthcsL.pphppuhp.hh.c......-l...tpah.+c.Ru..plEcpYup....p.....Lp...cLucchtttht...................sppp.............soh......................................................tpuapslh.sp.scphuptHtplupph........................................................................................................	0	361	566	953
+363	PF00111	Fer2	fer2; 	2Fe-2S iron-sulfur cluster binding domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	15.00	20.70	15.40	20.60	14.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.55	0.72	-4.23	206	17474	2012-10-02 17:47:23	2003-04-07 12:59:11	22	166	3695	266	5439	17310	7619	75.20	21	24.22	CHANGED	hphpup..thphpsssspp.lLcshc...p.t.slslshuCps.......Gs....CusCtsplhtu.................hpspphttt.h.....................LuCtshsp	.......................................h....sp...th.pl...p..s..s..s..s..p.s.....lLcshc.............p...t..........s....l...s......l......t......h.......uCpt................................Gs..C.Gs..Cp..lh.lh..p.Gps.........p...................ptp......t........................................................LsC.sh.........................................................................................	0	1464	3188	4405
+364	PF01799	Fer2_2	fer2_2; 	[2Fe-2S] binding domain	Bateman A	anon	Bateman A	Domain	\N	20.90	20.90	21.20	21.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.77	0.72	-4.08	157	5947	2012-10-02 17:47:23	2003-04-07 12:59:11	15	71	2180	114	2017	5159	1915	75.40	40	17.35	CHANGED	TlE..GL..............s.p..ssplcslQpAFl-ppuhQCGaCTPGhlhuutuLLc...p..................ps.ps......occ-.lccu.l.sG..NLCRCTGYppIlcAlpp	.............................................TlEGL.....................s.p.ssp.l..cslQpAahcp......pusQ..CGa.C.TPGhlMoshu.LLcp............................................ss...pP.............ocp-..I.c.cu.l..u.G.....N..LCRCTGYptIlpAlp.t.........................	0	620	1185	1606
+365	PF04324	Fer2_BFD	fer2_BFD; 	BFD-like [2Fe-2S] binding domain	Kerrison ND, Finn RD	anon	COG2906	Domain	The two Fe ions are each coordinated by two conserved cysteine residues. This domain occurs alone in small proteins such as Bacterioferritin-associated ferredoxin (BFD, Swiss:P13655).  The function of BFD is not known, but it may may be a general redox and/or regulatory component involved in the iron storage or mobilisation functions of bacterioferritin in bacteria [1].  This domain is also found in nitrate reductase proteins in association with Nitrite and sulphite reductase 4Fe-4S domain (Pfam:PF01077), Nitrite/Sulfite reductase ferredoxin-like half domain (Pfam:PF03460) and Pyridine nucleotide-disulphide oxidoreductase (Pfam:PF00070). It is also found in NifU nitrogen fixation proteins, in association with NifU-like N terminal domain (Pfam:PF01592) and NifU-like domain (Pfam:PF01106).	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.09	0.72	-3.91	190	6775	2009-01-15 18:05:59	2003-04-07 12:59:11	10	90	2902	2	1800	5000	364	54.70	27	11.81	CHANGED	thl..CtCpsVoctplppsl.....................tp.............hp...s.....hpplpptsts.............GssCG.sChs....ht......pllpptt	...................hlCpCpsVocupItpAl.....................tp..............tuspo.......lppl+ppTcs.........................Gss.CG...sChs..........ht....plltt..t...............................	0	527	1115	1483
+366	PF00037	Fer4	fer4; 	4Fe-4S binding domain	Bateman A, Eddy SR	anon	Prosite	Domain	Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.61	0.73	-7.60	0.73	-4.16	533	8206	2012-10-03 08:56:42	2003-04-07 12:59:11	22	662	2969	164	3310	39684	11065	23.50	39	7.69	CHANGED	hhlstcpChsCGtChpsCPssAlp	......h..ls.ccClsCGhChpsCPhsAI........	0	1442	2410	2918
+367	PF00210	Ferritin	ferritin; 	Ferritin-like domain	Finn RD, Bateman A	anon	Prosite	Domain	This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.60	0.71	-4.43	243	10640	2012-10-01 21:25:29	2003-04-07 12:59:11	19	13	4559	1610	2459	7325	1350	137.80	20	82.92	CHANGED	hptLNctlstE...htushtYhthuhhhc..shshtshsphhcppupEEh.pHApclh-hlhthG........G.....ph.......phhp...........h.................................s.ssh-hlctslptEpplspplpclhphup....pp......p..DhsotshL.pthlp-.p.cchthlpshlppl..cth	...........................................phLNctl...spp...hhuhh.hYhph........phhhc......shsh..slt..phh..cc.........ps.p-ph...p.....Hs.......-cl.h.-+lh..p..lG............u.....s...hphh...........thhp..........................h.....p..........................................................hs.ssp-h.lc...p...s...lp...t...p..p.t.l.s...........p.pl.p...c.h.h.p.h.up......pt................p..D......sotshl.pth.l.p-.pccphhhlpshlp................................................................................................	0	681	1367	1912
+368	PF01839	FG-GAP		FG-GAP repeat	Bateman A	anon	[1]	Repeat	This family contains the extracellular repeat that is found in up to seven copies in alpha integrins.  This repeat has been predicted to fold into a beta propeller structure [1]. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat [1].  The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding [2]. A putative Ca2+ binding motif is found in some of the repeats.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.94	0.72	-4.16	470	2456	2012-10-05 17:30:42	2003-04-07 12:59:11	18	220	351	67	1119	4198	1515	38.40	33	6.96	CHANGED	hstslssu..DlsGDGhsDlll..........................ssts....stlhlh	............Ghulusu..DlNGDGhsDlllG.....................................stptp......GtlYl.....................................	0	347	596	821
+369	PF02181	FH2		Formin Homology 2 Domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	25.20	25.20	25.20	25.20	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.25	0.70	-5.57	48	2361	2009-01-15 18:05:59	2003-04-07 12:59:11	18	102	317	21	1446	2150	30	329.40	23	32.57	CHANGED	tppt.psct+LKsLpWsKl..............................p.ssp.ps...........lWsclpppp..............ph-ht-h-thFsststpthtpt............................sstpppspclplLDs++upNluIhLppl..phshc-lhpulhph-p.phLs.............h-hl-pLh.chhPsc-Ehptl..p........phps-......hppLucsE...pFlhplsp.lsthppRlpshhFptsFpsplpplptplpslppAscpL+pScphpplLchlLthGNaMNsGst..GsAhGF+LsoLhKLsDsKus.-s+pT..LLHalsphltc.............................................phsclhshs.s-LpslccAuplsh-slppslppLpcslpplcpplptttp.......t.tptFhphhppFlppucpclcplpsthppshpthcchscYa...spssp....phs.pphFshlppFlphac	..................................................................................................................................h.....tsphth.h.h.W..pp..l....................................................................tp.h..pt.......................lW..sp......hp...ptt..........................................t.ph..t..c..hpthFttpttt...t...........................................................................t.tppp.pplpl..............L.-s.++upN.............ls.I..hL.p........p......h......p........h.s..........cc........l.t.....p...s...l..h..p..h..-p....ph..ls.............................................h-hl..p..p..Lh..phhP.p.p..cEh.phl.......p..........................ph...ptp..............hppLsps-..pFh.ht...h................p..ls.....php...t.....R.l.pshha.p......hpFpp...........p..h.p.p.lp....p..........lp..s.............ltt.Asp...p.......l.....p...pS....p.....p....hpp..lLp......h....lLthGNah..N....s..u..........p..................up....A.......hGF.c.L.s........L.+........L......t-.....s....Kus....c........p.p...........h...o......LLHal..s.ph.h.tp....................................................................................................................p.h.s..p..h..h..p.....h.........s-l..........ttl....p..p..A.u...p............l..s.hc.p.ltpp.............lppl.ppt.hpt.hpp.plph.tp.........................................h.....hp.h.h...........p......pFlpp...sp.tphp...tlpt..hp...p............h............p....hhpp..hhtaa..............s.ssp..........ph.p...p.phFthhtpFht.a.......................................................................................................	0	487	743	1102
+370	PF02661	Fic		Fic/DOC family	Bashton M, Bateman A	anon	COG2184 & COG3654	Family	This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing).  The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism [1].  This family contains a central conserved motif HPFXXGNG in most members.  The exact molecular function of these proteins is uncertain.  P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation [1].  A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1 [2]. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family [2]. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc [3].This domain forms complexes with Phd antitoxins containing Pfam:PF02604.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.65	0.72	-3.29	221	6829	2009-01-15 18:05:59	2003-04-07 12:59:11	13	61	3371	61	1631	5456	731	97.70	21	34.91	CHANGED	hls...hptlhp.lHp.tl......hppht............................Gth......Rs..h...................shhptshspsp.ph.thh..........thhs....................hhptuAth.thtlsphHPFhDGNtRsuthhhthhL	......................................................................................................................................p.t.lhplHp..hl..........hp.t.hht........................s................................Gph.........Rp.th...........................................................t.thp.h...h.h.s.t.st...pl..t.t.h............pphhphhp...................t..p...................htphu..hh.ahph.ttlHPFtDGNGRsuRhhhthhL..................................	0	529	1058	1363
+371	PF00254	FKBP_C	FKBP; 	FKBP-type peptidyl-prolyl cis-trans isomerase	Finn RD	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.95	0.72	-3.97	174	16739	2009-01-15 18:05:59	2003-04-07 12:59:11	23	143	5125	202	5251	12394	3280	99.80	27	37.70	CHANGED	ssp.sppGD.pV......plcYpGpl.........s...Gph..........FDuo..........h........+spshpaplGp...sp...VIp......................Ga-pulhs...........MpsG-ctplhlss.phuYGp......................................puh.s.......IPss.........................usLhF-V-Ll	..........................................................................................................................................................tt....sppsc..tV.......plcYp.G.pl....................D.........Gph..................................F.Duo..........................................................................pups.h..s...a....h.l.....G..t.............sp....lIs...........................................................G.a...-cul..hu.........................h.p....sG...-.c..h.p.l.h.ls...s...p..........u..YGt...........................................................................psh....s.................st.................................................pslhFclcl.....................................................................................................................................................................	0	1593	3021	4223
+372	PF01003	Flavi_capsid		Flavivirus capsid protein C	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)  	Family	Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E.  Multiple copies of the C protein  form the nucleocapsid, which contains the ssRNA molecule.	21.00	21.00	21.60	24.90	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.64	0.71	-4.55	27	4730	2009-01-15 18:05:59	2003-04-07 12:59:11	14	17	108	12	0	4102	0	108.70	56	4.51	CHANGED	ts.ups+slNMLKRshscs...httsKRhhhsLhsG.GPhRhVLAhlsFh+...FsulsPTsuLhpRW+sVsKppAh+tLpsFKK-lGshlssl.s+Rt++.tth.s.sshlLhl....hhlshshA	..................................KKstpsshNMLKRsRNRVSTspQLsKRFSh.GLLsGpGPh.KLVMAhlAFLR...FLAIPPTAGlLsRWGohKKssAIKVL+GFKKEIusMLsIlNRR++o.........shhLlMl....hsss..hhhh..............	1	0	0	0
+373	PF02832	Flavi_glycop_C		Flavivirus glycoprotein, immunoglobulin-like domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_146 (release 3.0)	Domain	\N	20.80	20.80	21.00	20.80	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.32	0.72	-4.10	12	9726	2009-01-15 18:05:59	2003-04-07 12:59:11	11	26	131	56	0	6580	0	95.50	58	6.56	CHANGED	oYsMCss.KFpapKsPuDTGHGTVVlcVpYoGssuPC+IPlpsssphpshssVGRLlTsNPhlsss..putVhIEhEPPFGDSYIlVGhGpppLshpWa+	..SYuMCTs.pFKlhKEsAETQHGTlVlclpYcGsDuPCKIPhsshD.hpshsslGRLITsNPlVosp..-ssVNIEsEPPFGDSYIVlGhG-ptLplpWaK.............	0	0	0	0
+374	PF00869	Flavi_glycoprot		Flavivirus glycoprotein, central and dimerisation domains	Bateman A, Griffiths-Jones SR	anon	Pfam-B_146 (release 3.0)	Domain	\N	20.00	20.00	20.60	20.20	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.83	0.70	-5.43	35	10895	2012-10-01 19:42:26	2003-04-07 12:59:11	15	32	141	36	1	7165	0	269.90	59	20.34	CHANGED	h+ClulpNRDFlcGsoGsTWVslVLEpGuCVTlhAcsKPolDlhLsshptps.AtsRcYChcAploshpssuRCPThGEApLsEEpsssaVCKRsaoDRGWGNGCGLFGKGSIVsCAKFoC...scphpGhhlptpplpYsVtlpVHsupttsstt......ssspttphphTspusppshsLu-Y..GplolsCcspSGlDhsphhlhpls......s+sWhVHR-WFpDLsLPWp.....tsusss...Wcsp-pLV-FcpPHAsK.sVhsLGsQEGulhpALuGAh.lphsusp...hpLpu.............GHlpC+lph-KL+lKG	.......................................+ClGluNRDFVEGlSGuTWVDlVLEtGSCVTsMAKsKPTLDlcLhphEApp.AplRchClcAploshoTsuRCPTpGEApLsEEpDtsaVC++shVDRGWGNGCGLFGKGS.llTCAKFpC...tpphpG+llQhENlcYoVhlpVHoG-pptsss.......ssppusphpITPpusosphpLs-Y..GslTl-CpPRoGLDhNphllLphc......sKuWLVHRpWFhDLsLPWo.....uuusTp...Wpp+EhLVpFcssHApKQ-VVsLGSQEGAhHoALsGAs.lph..Suss.....plhu.............GHLKCRl+MDKLpLKG.......................................................................................	1	1	1	1
+375	PF00949	Peptidase_S7	Flavi_helicase; 	Peptidase S7, Flavivirus NS3 serine protease 	Finn RD	anon	Pfam-B_199 (release 3.0)	Family	The viral genome is a positive strand RNA that encodes a single  polyprotein precursor. Processing of the polyprotein precursor into mature proteins is carried out by the host signal peptidase and by NS3 serine  protease, which requires NS2B (Pfam:PF01002) as a cofactor [4]. 	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.50	0.71	-4.75	50	3378	2012-10-02 13:45:52	2003-04-07 12:59:11	16	23	150	15	17	3915	116	149.10	68	4.59	CHANGED	hc.lpsGVY..RIhptulh.GppQ.......hGVGhhppGVhHTMWHVTRGAsLph...sstthsPtWus....V+cDllsYGGsWcLpt+WcG.c-VQlhAh.Pst.hp.hQspPGhhph.tG.plGAlslDaPsGTSGSPIl...NppGcllGLYGNGlhhs......ssYlSuIuQu	..............................................................................................................................................................................u.-L--GlYRIhQRGlL.GpoQ.......lGsGVhpEGVFHTMWHVTRGAVLMa...pGKRL.....EPsWAS....VKKDLISY...G...G.G.W+....Lp...up...Wpp.GEEVQVIAVEPGKNPKNV..............................................................................QTtPGsFKTspG.....E.....l...G.....A.l..u..L.D..F.pPGTSGSPIl...sR.cGKVVG.L.YGNGVVTp.....sGsYVSAIAQs......................	0	13	14	14
+376	PF01004	Flavi_M		Flavivirus envelope glycoprotein M	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)  	Family	Flaviviruses are small enveloped viruses with virions comprised of 3 proteins called C, M and E. The envelope glycoprotein M is made as a precursor, called prM. The precursor portion of the protein is the signal peptide for the proteins entry into the membrane. prM is cleaved to form M in a late-stage cleavage event. Associated with this cleavage is a change in the infectivity and fusion activity of the virus.	21.20	10.00	21.30	20.40	20.60	9.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.50	0.72	-4.55	30	4840	2009-01-15 18:05:59	2003-04-07 12:59:11	14	26	115	0	0	4095	1	71.00	55	2.92	CHANGED	SVslssHsppsLssRsp.sWhcucpspcaLs+VEsWllRNPsaAlssssluWhlGsohsQRlllhlhlLLlAPAYu	.......SVALsPHsGhGL-TRsp.TWMSSEGAW+plp+lEoWhLRpPGFsllAhhLAahIGoohhQR.slIFILLhLVuPSh....	0	0	0	0
+377	PF00948	Flavi_NS1		Flavivirus non-structural Protein NS1 	Finn RD, Bateman A	anon	Pfam-B_157 (release 3.0)	Family	The NS1 protein is well conserved amongst the flaviviruses. It contains 12 cysteines, and undergoes glycosylation in a similar manner to other NS proteins.  Mutational analysis has strongly  implied a role for NS1 in the early stages of RNA replication.	19.90	19.90	19.90	20.40	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.14	0.70	-6.04	11	4700	2009-09-11 01:25:55	2003-04-07 12:59:11	16	26	120	0	1	3925	0	270.30	70	11.15	CHANGED	hGCAIDhpR+EL+CGuGIFVas-VcsWh-pYKYhPEoPppLApslpcAac-Gl...CGlRSssRLEptMW+ultsELNhlLpENplcLoVVVscscshhppu..s+sLphpsc-LchuWKoWGKuhlaus-huNsoFllDGPpTpE..........CPsppRAWN.....sacVEDFGFGlhoT+laLclREcsTpECDotlhGsAVKss+AVHoDhoYWIES.phNsTWplE+A.htEVKsCoWPcoHTLWu.sGVlES-hlIPhoLAGPhSpHN+RsGY+TQspGPWcpsclclDF-aCPGTTVslsEcCspRGsSlRTTTsSGKLIs-WCCRSCTLPPLRFpspsGCWYGMEIRPl+ccEssLV+ShVsAssGp	................oGCVIsWKs+ELKCGSGIFVTN-VHTWTEQYKFQs.-SP.p+.L.As.uItpAa..c..-Gl...CGlRSsoRLEphMWcplpsELNhlL.EN.thchol..h..s..sc...G.hhttu...+.lpsps.chchuWKsWGKuh......hh......ss-.t..NpoFllDGPpT.E...............CPstpRAWN................hEVEDaGFGlhoTplaLKlR-t.s..CDp+lhusAlKsphAVHuDhuYWIES..th..Nto.WKlt+AshhEVKoChWPcoHTLWu.sGVLES-hIIPt.huGPhSpHNhRPGYhTQstGPWc..G+lEhDFshC.GTTVslsEpCGpRGPSlRTTTsoGKlIp-WCCRSC...TLPPLRahs-sGCWYGMEIRPhpccE.cshVpS.VsAhpu.p................	0	0	0	1
+378	PF01005	Flavi_NS2A		Flavivirus non-structural protein NS2A	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)	Family	NS2A is a hydrophobic protein about 25 kDa is size.  NS2A is  cleaved from NS1 by a membrane bound host protease [2].  NS2A has been found to associate with the dsRNA within the vesicle packages.  It has also been found that NS2A associates with the  known replicase components and so NS2A has been postulated to be part of this replicase complex [1]. 	25.10	25.10	25.20	40.20	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.28	0.70	-5.05	37	3339	2009-01-15 18:05:59	2003-04-07 12:59:11	14	19	108	0	0	3344	0	208.40	46	6.38	CHANGED	Gllslhlshp.llR+Rh..Tu+thlhuulhlLslhlhGhlThpDLhRYllhVGhsFst.psGs-lhaLsLl.AsFclRsuhLsuahLRppaTsREslllhluhshlphuhst....h.hslhphhculAluhhll+Ahsptppssluh.llulhs.tthhhlhtuhphhlhllsssulhp.t+ssst+.Kshshllslu.....lhus.Ghh..hlshhtlhhtps.t+.R	................GlLslulhhEEVhRsRa..upKhhhsullssFllLlhGplTapDLhRhsIMVGAshoD.chGMGlTYLALh.ATFKlpPhFAlGhhLR.+LTS+EslLLslGluhhspsp......LPpsl.-lsDuLAlGhMlLKllTphpsaQLhssLluLossssthhLpsAW+shshlLulVSLhPLph.oootQ.Ks.s.WlP.lsLu.....hhGs.....sPlshFlhshs+s.p+R...............	0	0	0	0
+379	PF01002	Flavi_NS2B		Flavivirus non-structural protein NS2B	Finn RD, Bateman A	anon	Pfam-B_156 (release 3.0)	Family	Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. All, but two, are cleaved by the NS2B-NS3 protease complex.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.29	0.71	-4.55	30	3263	2009-01-15 18:05:59	2003-04-07 12:59:11	14	18	115	15	2	3330	1	127.00	55	3.81	CHANGED	hoEslTAVGlhhsLsuulh+.sssphhsPhssuGllllsYlloG+sssLhlE+su-lpW-p-AphoGuSscLcVchDspGsh+Lh--ctsshphhlhhsshlshuAhaPhuIhhshsuWahhp...pss+R	......LNEulMAVGlVSILsSSLL+.NDlPMAGPLlAG..GLLhACYVIoGpSADLpLE+AADVoWE--AEhoGuScpl.VplsDDGoMpIKs-Ec-shLTlLL+ssLLslSGlaPhSIPsTlhsWahWp...pppQR...............................	0	0	0	2
+380	PF01613	Flavin_Reduct		Flavin reductase like domain	Bashton M, Bateman A	anon	Pfam-B_710 (release 4.1)	Domain	This is a flavin reductase family consisting of enzymes known to be flavin reductases as well as various oxidoreductase and monooxygenase components. VlmR is a flavin reductase that functions in a two-component enzyme system to provide isobutylamine N-hydroxylase with reduced flavin and may be involved in the synthesis of valanimycin [1]. SnaC is a flavin reductase that provides reduced flavin for the oxidation of pristinamycin IIB to pristinamycin IIA as catalysed by SnaA, SnaB heterodimer [2].  This flavin reductase region characterised by enzymes of the family is present in the C-terminus of potential FMN proteins from Synechocystis sp. suggesting it is a flavin reductase domain [1].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.19	0.71	-4.37	141	7912	2012-10-02 11:35:36	2003-04-07 12:59:11	13	38	3556	70	2331	6180	2131	151.60	19	73.61	CHANGED	htp..hsssVsllos.t........sspsh............G....hss.oshsslShc.P.Phlh.hsls.......pp...............................................................................spohshlpp...ssp............Fslsl....Lsp.sp.tp.lu....ptFus.......................tttc+..hs.shphpts.......................sus.......Phl..psuh.uthcC...clhp..p......hss.G.s............HslhlucVhsh...thtps..t.................Llahp.tpapshs	.................................................h.....hstslslloo..st.............suths..............................s.........hss.oh......h...s.s...l....sh..s....P..Ph....lh..l....s.ls...........pp................................................................................ppohth.lpp...ssp..........................Fslsl........lst...sp...t.....p..hs.............pthus..s................................................tt-+......h..s..slshttu.........................................sus..........................P.hl........pp.uh..sth-C..clhp....h..................hph...G.s.................................................................as.lhl..ucl..h.s.h........thssp......................................................h......................................................	0	675	1440	1926
+381	PF00258	Flavodoxin_1	flavodoxin; 	Flavodoxin	Finn RD	anon	Prosite	Domain	\N	24.40	23.20	24.40	23.20	24.30	23.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.84	0.71	-4.19	92	10556	2012-10-03 05:08:30	2003-04-07 12:59:11	20	121	3998	199	2717	8477	791	138.50	22	32.80	CHANGED	llYuSpoGsscphActlscthpt.tsh.spshshtphs.........tpl.ptthllhsssThstGpss.s.......h.phhthh.............................................................tt..htshphulhGhGspsatt.......attssptlcpplpp.hGuppls......................shsts-pps...shcpthptW	.....................................................................lhauS.p.o.Gssc.t....l....Ac.t...........l.t....ct.l............t..........t..................s............h...........p........s..........p........l....h...s..h.s...c.hs...........................tpl..t.p....t......c.....h...l..lls...s..u..T.a...G...p.G.-...hP.pp................h.h.c.hhp...h...........................................................................................tt...pL..s.s..h..p...hulh...G.h....G...D..psatt..................FstuscplcptLpp.hG.u.p.h.ls............................ttlth.D....p....t.......ct..........................................................................................................................	0	813	1530	2194
+382	PF04500	FLYWCH		FLYWCH zinc finger domain	Krauss V, Dorn R	anon	Krauss V	Domain	Mutations in the mod(mdg4) gene have effects on variegation (PEV), the properties of insulator sequences, correct path-finding of growing nerve cells, meiotic pairing of chromosomes, and apoptosis. The  occurrence of FLYWCH motifs in mod(mdg4) gene product and other proteins is discussed in [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.26	0.72	-4.08	128	1130	2012-10-02 23:28:20	2003-04-07 12:59:11	11	45	72	1	775	1222	0	60.70	23	26.35	CHANGED	ahpop+.Gpth...LlhsGahatpsppp.....s.sptaWcC.sphpp......hpC+ARlhTp.....sspplhhhp.s....HNH	..............hhstp.Gt.h....L.l.hp.u.ahYptpppt.............s.sphhWpC.spppp...........pC+u+lhTp.............stplhhhp..t......HsH..................	0	187	296	645
+383	PF03358	FMN_red		NADPH-dependent FMN reductase	Mifsud W	anon	Pfam-B_2010 (release 6.6)	Family	\N	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.81	0.71	-4.71	276	11795	2012-10-03 05:08:30	2003-04-07 12:59:11	10	50	3935	96	3325	13002	2408	145.70	18	69.81	CHANGED	h+llsl.sGSs........R.......ps......uhsptlsphstp......hh.....t.........t.h-s...............cll.-....lsch..hP.....hhstch.............ssts.....pphtppltpAD..ulllsoPEYssuhsusLKshlDhhs........................tpthp.sKss...............uhl..ususu.tGuhpshtpL+thhs....hpshslss.thslstshp	.........................................................................................plhhl...G..S....p...................tt.......u..h.sptl.s..p..h..htc...................th......tt..................................s..h-s..........................phh...p...........lsch......hs.............................hh.s.tsh.................................tssh...................tt.h....h....p..p......l.t.p.AD...ullhuoPpYht...uhs..........usl..Kshl.D.h.hs...................................h.tpsht...sK.ss........................................s.lh........ss.u..s....s..........t..u.......s...........p...s.........h...p...h.t..h.h...h...hth.hhh.s............t............................................................................................	0	1024	2182	2831
+384	PF02434	Fringe		Fringe-like	Mian N, Bateman A	anon	Pfam-B_1900 (release 5.4)	Family	The drosophila protein fringe (FNG) is a  glucosaminyltransferase that controls the response of the Notch receptor to specific ligands [2]. FNG is localised to the Golgi apparatus [1] (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homologue, lunatic fringe, has been implicated in a variety of functions.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.81	0.70	-5.17	27	1045	2012-10-03 05:28:31	2003-04-07 12:59:11	11	26	186	2	715	1675	8	183.50	22	50.40	CHANGED	p.hphcD..lFIAVKTT+KaHcsRlsllhcTWhspA+cQTahFTDs-DppLppp.....hs.pllsTNCSssHsRps.........LsCKhuspaDpFlpSsp....+WaCHVDDDNYlNlspLlcLLssYshopDlYlG+PSls+Plpshct.............................p.spFWFA.......TGGA..........GFCl..................SRuLALKM..........P..aAStuphhssuctlphPDDCTlGaIlpshLslplh+osLFHSHLEsLtplsspplpcQV............................olSYuth....sphNhlphtts...Fs.ppDPoR	............................................................................................................h..........................ph.......l....t..TW.t.h..................................h....................o.....s.........................p..t....h...................................h.........t.....tt....................t..............................h.t.h....h........h......h...t..h...h...h..p..s..pt................cWahhsDDDT.Y.l.....hpsLh.p...hL.....p......s......a....s.....s..s....p...s...l.Y.lG...p.............h......s.h...h.pt.........................................................a.h.........sGGA.........................Gasl..................S+t.hhp+.h........................hh.p.t.t..p....h....p....s..t....................-....Dh......h.Ghhhtt...hth....................................................................................................................................................................................................................................................	0	208	292	533
+385	PF01534	Frizzled		Frizzled/Smoothened family membrane region	Bateman A	anon	Pfam-B_949 (release 4.0)	Family	This family contains the membrane spanning region of frizzled and smoothened receptors.  This membrane region is predicted to contain seven transmembrane alpha helices.  Proteins related to Drosophila frizzled (Swiss:P18537) are receptors for Wnt (mediating the beta-catenin signalling pathway) [1], but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding [2].  The smoothened receptor mediates hedgehog signalling [3].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.19	0.70	-5.65	11	1043	2012-10-03 04:04:29	2003-04-07 12:59:11	12	9	159	0	557	939	0	269.20	38	53.08	CHANGED	saFop-E+pFschWIGlWSslChhSTLFTVhTFLIDhc.RF+YPERPIIFLSsCYhhVSluallphhst.c-cluCst.....................................tttttpplp.sohpspuCTllFlLlYFFsMAuSlWWVILolTWFLAAGhKWG.pEAI-t+upYFHLuAWulPulpTIslLAlupVDGDsloGlCaVG.hshcuLpGFVLuPLslYLllGshFLLAGhVSLF+IRolhpppG.....spo-KLEKLMlRIGlFSlLYhVPAslVluCYhYEttptspWthshhsp.Ctphp...s.s.t....s...t+Pp.hsVhMlKYhMsLlVGITSusWlWSuKTlpoW+pahpRhps+	............................................................happp-hphs.phaluhhuhl.C.h.huThFT..l.hTF.Ll...Dhp...R....Fp....Y.P..ERPIlaluhCY.h.hSlua...lhthhh.....tcplsCst................................................................................t.t.t.....p...h...l..h.....t......s.....p..stuCsllFhllYaFsMAuolWWVlL...olTWFL..AAu.h..K....W....u..pE...........AI...........p..t.......p......upY...F..........HhsAWu..lPul.hTlslLsh.sp......V...-....G.....D.l.o.Gl..CaVG...s..hp....s.LpsF....VLsPLhlhLhlGs..FLlsGh.l.u.L......h+lRp.hpptt...................ppscK.L.c...+hM...lR....IGlFohLYhlPsh..hlluCahYE.h.ht.W.....t...h.....h....t.......h.................t.................................................................................................Pph.lhhl+hhh..h.llG.IssuhWlh.o.t.KTh...pWtphhpt....p...........................................................	0	125	171	367
+386	PF01827	FTH	DUF38; 	FTH domain	Bateman A	anon	Pfam-B_67 (release 4.2)	Domain	This presumed domain is likely to be a protein-protein interaction module [1]. It is found in many proteins from C. elegans. The domain is found associated with the F-box Pfam:PF00646. This domain is named FTH after FOG-2 homology domain [1].	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.74	0.71	-4.59	87	1268	2009-09-12 02:26:25	2003-04-07 12:59:11	22	47	6	0	1226	1298	1	138.50	17	38.99	CHANGED	pphhp..thtphLcs....tpslpl+plp.lpthsh...........s.clhslLsh...FpsphLcpIpl.........................ptpphpphccls.pL-QWKpAKplp..hpsthh.......sI-plhHFppFpl.phsp..hoh.pDslclRD.......L.hpsss....Fppspl..............ph.phsshcls+lFp.Pp	...........................................................................................t....t.h.phlps...pp.l..p..lcplp....l..p.s...h..s.....................p...p.l..h...p.l.Lsh...hcs.p.hLc.plpl............................................tppt.p..h....h.p.h....p....c.l....h..ph....-...QWK....p.Ac.p.lp.........lp.shhh...t.............slc..p..h..h..Hhp....p.h.p..l...ph......p..........p........h..oh..pc........lh.......t....l+ch..................h..hpp.s.p.......h.p.h.h...................................................................................................	1	257	261	1226
+387	PF01913	FTR		Formylmethanofuran-tetrahydromethanopterin formyltransferase	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	This enzyme EC:2.3.1.101 is involved in archaebacteria in the formation of methane from carbon dioxide. N-terminal distal lobe of alpha+beta ferredoxin-like fold. SCOP reports fold duplication with C-terminal proximal lobe.	19.60	19.60	19.80	21.90	19.50	18.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.88	0.71	-4.47	36	245	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	155	24	95	260	64	134.40	49	47.64	CHANGED	MclNGVpI-DTFAEAFshpssRllITAtoccWAhpAApcsTGFuTSVIuCssEAGIEp.hlsPsETPDGRPGssIhlh....shstcpLccQlhcRlGQCVLTsPTTAlFsul...........tpphslGtpL+aFGDGaphpc..clsG.....R....+hW+lPl	.............l.-TFAEAFshtssRlllTAts.cWAhhAApshTGFATSVIuCssEAGIE+..LsPs.....ETPDGRPGlul.LlF.....uhutctLt..+Ql.pRlG.QCVLTsPTTAsFsGl..........................p...sscplslGtpLRaFGDGaQhuK..pl.sG.........+RaWRlPV..	2	27	67	82
+388	PF02741	FTR_C		FTR, proximal lobe	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	The FTR (Formylmethanofuran--tetrahydromethanopterin formyltransferase) enzyme EC:2.3.1.101 is involved in archaebacteria in the formation of methane from carbon dioxide. C-terminal proximal lobe of alpha+beta ferredoxin-like fold. SCOP reports fold duplication with N-terminal distal lobe.	25.00	25.00	37.30	36.40	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.72	0.71	-4.43	38	245	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	155	24	95	256	56	142.80	52	50.61	CHANGED	-GEFlsE-phGhh.cGVuGGNFhlhucsp.uALtAAEAAV-AlppVpGsIsPFPGGlVuSGSKVGop...Y.+h.lsASTN-taCPTL+sp.s.cSclPssVsuVhEIVIDGlsccuVtcAM+sGIcAAs.....pssGVl+ISAGNYGGKLG.a+F+L+-L	.-GEFlsE-shGhs.cuVGGGNhLlLAcspssALtAAEAAVsAhc.plssVIhPFPGGlVRSGSKVGS+...Y.+t.ltASTN-AaCPTL+uh.s.cScLs.....s....-lpuVhEIVIDGLsptsVttAM+sGIpAus.....thsGlhcIoAGNYGGpLG.h.h.L.t.............	0	27	67	82
+389	PF01728	FtsJ		FtsJ-like methyltransferase	Bashton M, Bateman A	anon	Pfam-B_1791 (release 4.1)	Family	This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesised that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.27	0.71	-4.29	239	10200	2012-10-10 17:06:42	2003-04-07 12:59:11	14	62	4426	60	2263	11482	3102	173.80	25	13.42	CHANGED	ahS..RuuaKLhph.cpa...........p........l..............................................p....ph.slDlGuuPGGaopshhpps.......................................................sspVhulDlt.h............................phshtl..........puDh...............tsh....hshp.plhph.....................................................................................................sDlllsDh.......................................p.phhuh....pLshsslt.hs................................p...................ssG...................hlsKlhp.....................stph.p.pllpplpp.......tFph.....................................................lthh+ss..........so+s.pu.sE.....a...llshth	................................................................................................................hSRuuhKLpth....hcph........h........l.........................................................................................ps.......tp.l..lDL..G...susGG.Wo...hhsptt.................................................................................................................stcVh.u..lDhG...s.s..........................................................t...............hs....p.h..................pt.sh...........................hch.........pshp...sl..h....h....s...t........................................................................................................................................................................................................................................tpsD.h.l.l.s..Dh...........................................................u.....................s......shl..p.h...............t.h.s...l...h.s....Lp...h..s......h..........................................................................................................L..p..............................ss..s.......................................h.s...lK....lhp............................................................hh......pllc.ph..cp...............h..p.p......................................................s..t..lh.+.ss..........hSRs..ps..pEh....ahls...h.................................................................................................................................................................................................	0	771	1367	1878
+390	PF02687	FtsX	DUF214; 	FtsX-like permease family	Bashton M, Bateman A	anon	COG0577	Family	This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.51	0.71	-4.35	133	37091	2012-10-03 05:18:07	2003-04-07 12:59:11	16	39	4654	0	8576	29605	7637	121.80	17	28.36	CHANGED	hhhshlhllluhlslh..shhthtlt.....p+ppchulh+slGhsppplhthhhhcshll....shluhllG.hlluhhhshhhtphh................................................hhhshhhshhshhhshh...hshhlshlsshhsshphtp.hss	.......................................t.hhshlhlllusls....lh......shhh.htlt.........pRp.cElul.h+s..l.G...ssp.pplht.hhhhE....shll......ullu..sllG...lh....l..u....h.h...h..s..h...h...l..t.t.hh.................................................................................................hths.h...t...h...s...h...h...s...h....l....h....s..hh.........hsh.l.l..s.l..l.s..u.h.h.s.shphhph.................................................................................................................................	0	3457	6175	7555
+391	PF04082	Fungal_trans		Fungal specific transcription factor domain 	Wood V, Finn RD	anon	Pfam-B_306 (release 7.3);	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.79	0.70	-5.52	102	10823	2012-10-01 23:57:08	2003-04-07 12:59:11	13	234	216	0	8645	11592	1	237.30	12	31.77	CHANGED	lphaaph....hp.sha............sll+c...ssahpph.............................spshLl...hsllslGsthtpptttpp.........................................................................phphhh.............pht.sspplhhlQ...uL....lllphathths...s..pphtht.....................apGhslp.hspshuLptpsst.p........................................hshp.tEh...p+.......RlaassahhDphhuhhhGpss......h...htspplphs....LPssss.h..stp.tt.t.............................................hhhhhpLp....plhsp...............................................lhs.lhshptphpppptp..........................hpplppplptWpp	................................................................................................................................................................................aht..........h....h..h.......................h....lp................ph.tth...............................................................................................h..lh................hsl..h..s...h..u...s........h.....h......t...t......t........t................................................................................................................................t.t.thhh...................................................t...h.t..t..s..p..l.t...t..lQ.............uh.................ll..h....s......h...h.h...h....tts....................p....p....t..s.ah................................hh..u.h..u..hc....h..u...h......p....l..G...L....+..p..p.s.s.t..t........................................................................................hs........t...-h........+..+...................R..l.....aW.s.lah...h...D..........p.............h...h...u.....h...t...h..G..p..s............................h...............hp.p..p..p..h..s.h........................h..P.....t.............t..............................................................................................................................................................................................................................................................................................................................................h...............................................................................................................................................................................................................................................	0	1444	4077	7109
+392	PF01363	FYVE		FYVE zinc finger	Bateman A, Armstrong J	anon	Pfam-B_655 (release 3.0)	Domain	The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions.  Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.  We have included members which do not conserve these histidine residues but are clearly related.	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.60	0.72	-4.08	174	4289	2012-10-03 17:27:21	2003-04-07 12:59:11	16	325	331	13	2818	4121	81	71.10	32	8.02	CHANGED	stWhsD.pps.spCht..Cpp.pF.s..............h..........h....pR+..HHCRpCGp....................lhC.......................................ssCS.........................spph.hh..............................................................t.ths.....psh..................................................RVCssCaptlpp	............................Wh.D.ppsspC..ht.......C.p..p.....p.F...s.............................h.........................................h.....pR.+......HH.C..R.........t.........CG.p........................lhC.......................................spCS................................spph.ls........................................................................................................h.t.t.pss...........................................................................................RVC.st.Capth..t..........................................................................................................	0	898	1408	2169
+393	PF01392	Fz		Fz domain	Bateman A	anon	Bateman A	Family	Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4].  The domain contains 10 conserved cysteines.	22.60	22.60	22.70	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.53	0.71	-3.73	26	1926	2009-01-15 18:05:59	2003-04-07 12:59:11	17	130	149	11	1122	1701	0	112.50	29	19.98	CHANGED	Cpsls..hshCpslsYstshhPNhLsHps..psEsthp.....hspahsLlph......pCpsshphFLCuhasPhC.hspht.....l.PCRshCEts+p.tCtslhpt...........ashtWP-hLcCschPh.pc.......hCh	....................................................Cpslp.....h.hC..p..s....l..s.....Y.s.h.T.h..h.P....N.....h.l..s..a.ps....pp-s.thp............................hp.t.a.h....sL.lph..........pC....p..s....p...l..ph..FLCuha.sPhC...p.p...h.......t.........................l.PC...R...slC...cps+p...tCp.slhpt.....................hs.htW.Pc..hhpCs.ph.P.tst.......C...........................................................	0	341	427	729
+394	PF01585	G-patch	G7; 	G-patch domain	Bateman A	anon	Pfam-B_585 (release 4.1)	Family	This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains.  This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.	20.30	20.30	20.30	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.14	0.72	-4.17	55	3420	2012-10-01 21:03:39	2003-04-07 12:59:11	18	129	386	0	2214	3446	25	44.30	34	7.29	CHANGED	ssshGhchhp+MGact...GpGLG.....csppGltpPlpsphpppp......tGlGtp	.............pshGt+hL.p.K.MGWpt.................G.p..GLG...............pp....t.p.......G.h...t..p..Plp..sphpp..pp.......tGlGh..............................	0	704	1102	1668
+395	PF01019	G_glu_transpept		Gamma-glutamyltranspeptidase	Bateman A	anon	Pfam-B_878 (release 3.0)	Family	\N	19.10	19.10	19.30	19.30	18.90	19.00	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.63	0.70	-6.02	52	5126	2012-10-03 21:14:07	2003-04-07 12:59:11	16	27	2591	76	1814	4680	4706	454.30	29	87.76	CHANGED	hclLcp..GGNAlDAAlAsshsLuVlpPpusGlGGGuFhllhsssstps..sl..suREpAPtssot.....cha...........tsttphsthGsh.uluVPGtlsGhtphac+aG..plshtpLlpPAIcLAccGaslstthutshtpttth...hpppssht.......phF.....hs..sGps.hcsG-hhp.pPsLAcTLctlAp..pG..............scuFYpG.c..lAcpllcp..........hpp...t..GGllTtcDLssYc...s.chtpP.lpssa..s.........thtlhtsPPsouGhslh.hLslL-pas....tt............spthHhllEAh+hAaucRsp.lG........DPsass....s....hppLlsppaspphtptIssppshs..........................................................h.......t..sssToHhullDppGNsVShTpolshhFGSslhsstoGllLNNchsDFo...........ls.sstsN............tltPGKRPhSohsPsllhc...sGpshh..slGssGGspIhsshhpsllph.....lphshs.............lppAlsuPRhap.....p..s........plphEt.........shstphhptLp..ptG+plphhts.sshstshhhh......................tsushhuuuDsRpsG	...................................................h.clLc.p..GGNAlDA.........A........lAsshs.LuVs.............p.P.p..us..G.l.G.G..suFhl.....l.......h......s.................s................p................s........t......p...........h.........................sl...................s.h.......p...thA....P...t....t..s.s..........pha.........................ttts.....t...t...h..s..h...h....u.h.......h..u.......l.u.l.PG..s.l....tuh....t........h.....h.....p.....+.....a...G.............ph.shppllpPAIp.lA..c.p...G.a....................ls........t....hs....p....h...h........t.........ptttt..........htp...........s..h.t.........................th.F........................h..........pG...ps...h......p...............G.......c..h.....hh..ps.....p.......LApTLchlAp..pG................................scu.F..Y..p..G..p.....lAc..plstt....................................hpp...........t.....GGh......lohpDL.ts..Y..p..................s..t...p.............p.P....lss.sa....t..............................................hhhl.h......P.P.s.u.s.G..........l.s.h.ht.h.L.s.lL-.ths.......htth.s.ts.......................................................spthHhhhEAh.+hA.au...........D.R.spa..l..u...............Ds.s..ahp....................hptLl.s.p..s.Y.h.tph..t.p......Is.p....p.shs...............................................................................t.....p.....tss...TsahsllDppG...s.sVS.......hTpolt.h..........hFGSul..h..s.........st.....s.....GhlLNNc.h.s.sFo..............................hs.ss..tsN......................tl.t..P....s.KRP.h.oohs.Psl...lhc.............s...............u.................p...s......hh...............sh.G.s.s...G.G..sth.....pshhpsllsh...............................ls.a..s.h.s....................hppAlst.PRhtt...............p........................plp.hEp........................sh.s.........p...h.h..p.tLp....thG.a.p....l....t...h....h...t........h........t....s...h...t...t..h.hhh............................ss..hh.uuuDsRpt....................................................................................................	0	561	1043	1459
+396	PF04114	Gaa1		Gaa1-like, GPI transamidase component 	Wood V, Finn RD	anon	Pfam-B_12685 (release 7.3);	Family	GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex.  Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase  that adds glycosylphosphatidylinositols (GPIs) to newly  synthesised proteins. 	19.50	19.50	23.20	20.20	18.90	19.20	hmmbuild  -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.80	0.70	-5.80	4	376	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	269	0	274	373	2	347.30	24	66.68	CHANGED	hpGpNlYGlLRAPRusuTEulVLsVPapsusu.phN.puuVuLhluLAcaFpthshWuKDIIhlloEpshhGhpuWLEAYHD.....shshh..pP..LphRuGSIQAAlsLElsosEssp..l-Vth-GLNGpLPNLDLhNlhppIht+cG.hsthph+hpspDhpopss..ps..L+pLhhhlhsQAsusspusHG..LF.pYRI-uLTL....R.h+uptphuaDhsshG..+AlEuhFRSLNNLLE+hHQSFFFYlllu.p+FlSIGsYMPullhLshshhLpAhptWhs.ttsshsL.cshu.....t..s.L.s...s.hhtl.asolsu.hLlophhthssalh.hLtpphht..hssh.hpssshhhLSl..huhhh................h.hhhlhsLlhhuhtlsslulhNFSLuhlsAhhhVP..lth.sKccspR.....olhhAsLshps.hlhhlslLhl..hphs.sPht.lhhcshphhhshls.uVhthlshsshla.VlshhahPhWllhhshohpK	..................................................................................................G.slaulhp.A.PRusu....sEuhVlss.s...........................s.........................p..............s..............s.....tulslhlslhpa..hp..p....hW.u.KDllhl..h...s...................p..........p.........h.................u....h....p....uWlcsYHs............................................................l...h..puGs.l.puAlsl-..h.s....t..t..........t............lplhh-GhNGpLPNLDLh...N.hh...............th....s.t..t..t......................t.h.....t...............t................................................................t..t...t.................hpt....hh..hh.hh..p...tu.....u.h.s.p.ss..Hu.......Fh.aplpulTl...............................t.s..h...t..p.....................s.....h..t..hG........+hlEuhhRslNNLLE+hHQSaFhYll.t.ppFlSIu.Y.h...shhh...lhhs.hhl............u..h....h..t..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	92	160	233
+397	PF01590	GAF		GAF domain	SMART, Hughes J	anon	[1]	Domain	This domain is present in cGMP-specific phosphodiesterases, adenylyl and guanylyl cyclases, phytochromes, FhlA and NifA. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP, respectively, these products up-regulating catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding. Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally-stable states that are reversibly inter-convertible by light: the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region. This domain is also found in FhlA (formate hydrogen lyase transcriptional activator) and NifA, a transcriptional activator which is required for activation of most Nif operons which are directly involved in nitrogen fixation. NifA interacts with sigma-54.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.70	0.71	-4.09	450	14959	2012-10-02 14:34:25	2003-04-07 12:59:11	21	1267	4851	93	4355	20618	2072	147.20	15	24.89	CHANGED	shpplhpphhpplt.phhssspshl......................................................h..hptpthhh.hhhth.hsp............................................tthth.httsh............................hspshpsspslh...................h.........shhhtt...............ththpuh..hssP....h...hsp.......tp.........................lhGllsltppps....................ctasppc....hp....llpt.luppluhsl	.............................................................................................................................................................................................................................hhpth.hptht.ph.h.s.h.ct...shl........................................................................................h...h..p..t.....s.....t....h.....................h....h...t.h...s..h.sp....................................................................................................t...t.t....h....h......h...t..p.sl............................................................h.t..p....h.h....p....s......s...p..s.h.s...............................................l.t.....s....h...t.........p....p.....h.........t...........s..h..s......t...p..t..................................................th.t.h.p.u..h...lshP..................l..ht.p..................sp...................................................lh..G.ll..s..h..pppps.....................................+hh..s...t...t.p..ht...........lhps.hutthsh........................................................................................	0	1335	2627	3635
+398	PF01140	Gag_MA	gag_MA;	Matrix protein (MA), p15	Finn RD, Bateman A	anon	Pfam-B_229 (release 3.0)	Family	The matrix protein, p15, is encoded by the gag gene. MA is involved in pathogenicity [1].	20.80	20.80	21.00	22.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.88	0.71	-4.28	9	296	2012-10-01 20:35:47	2003-04-07 12:59:11	14	20	82	4	9	313	0	123.90	61	20.54	CHANGED	GQolT....TPLSLTL-HWcDV+cRA+NQSVEl+Kt+W.ThCsuEWPTFsVGWPt-GTFNhslIhQVKphVFp.sPaGHPDQVPYIVTWcuLAhsPPPWVcPFlsPs......hsPos.stPsuPs.PSsP.pss..LY	.............GQTVT....TPLSLTLpHWsDVp+hApN.QSVDVKK.RRWlTFCSAEWPTFsV....GWPpDGTFNlsII.QVKu+VFsPGPHGHPDQVPYIVTWE.ALAhDPPPWVKPFVsPK.........s..Po.AP.hPssPs..spsPspSs.................................................................	0	4	4	9
+399	PF01141	Gag_p12	gag_p12; 	Gag polyprotein, inner coat protein p12	Finn RD, Bateman A	anon	Pfam-B_821 (release 3.0)	Family	The retroviral p12 is a virion structural protein. p12 is proline rich.  The function carried out by p12 in assembly and replication is unknown.  p12 is associated with pathogenicity of the virus [1].	25.00	25.00	33.60	33.60	24.50	21.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.06	0.72	-3.85	10	138	2009-09-12 05:17:05	2003-04-07 12:59:11	13	8	48	0	0	153	0	81.50	71	10.13	CHANGED	PALTPolpsK..P.KPQVLP.DsGGPLIDLLTEDPPPYtsPtPsPPst-ssctEAssssEsP........sPSPMA.....SRLRGRREPPsADSTTSQAF	..........PALTPSIKsK..PsKPQVLP...DsGGPLIDLLTEDPPPYGsQ..PSSSst-sscEEAssTuEls........sPSPMV.....SRLRGRRDPPAADSTTSQAF.....................	0	0	0	0
+400	PF02140	Gal_Lectin		Galactose binding lectin domain	Mian N, Bateman A	anon	IPR000922	Family	\N	21.30	21.30	21.60	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.31	0.72	-3.67	126	1519	2009-01-15 18:05:59	2003-04-07 12:59:11	13	122	181	22	813	1468	19	79.30	33	12.15	CHANGED	LpCs.s..phlplp.hAsYGRss..s.sC......s...hppsp................Cpus....s.ohshlpp.....pCpG+psCs.lsss.sssF...uD.P.C.sushKYLpV.....papC	..........................................................LpCsss....pll.tIp.sAsYG.......Rss.....sth..C............st.....t..p..h.p..p.h..p...................................Chss.......suhphl...pp........p.C.p....s+..p.....p.....Cs.lsss..sssF....sD...P....C..s.G.o.h.K..YLpV..pYpC......................	0	314	482	674
+402	PF03127	GAT		GAT domain	Bateman A	anon	[1]	Domain	The GAT domain is responsible for binding of GGA proteins to several members of the ARF family including ARF1 [1] and ARF3. The GAT domain stabilises membrane bound ARF1 in its GTP bound state, by interfering with GAP proteins [2].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.10	0.72	-4.04	33	1104	2009-01-15 18:05:59	2003-04-07 12:59:11	9	17	265	13	629	997	2	98.80	23	18.93	CHANGED	tps-phuKht.scl-pVpsssclLsEMLsphssupppss-.-....Llp.......................-LhppCcphppplhcLh.........scspD--..sls-lLplNDsLspslp+Ycphscspps.tp....sts	...................................................t...t.htphh.splp.l.p.s.ss.clLsEMLpp.hs..s......s.....p..p..p...s..s.c..-......llp.................................-.LhppCcphpppl..hcLl........................................sp..sp-.--...h..l..tcl...LpsNDpLspsltpYcp.htpsp.......ssst.........................................	0	138	279	452
+403	PF00320	GATA		GATA zinc finger	Finn RD	anon	Prosite	Domain	This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors.  However there are several proteins which only contains a single copy of the domain.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.18	0.72	-4.60	69	3798	2012-10-03 10:42:43	2003-04-07 12:59:11	22	92	384	40	2299	3654	15	35.30	45	8.26	CHANGED	Cs..sCsTop..TPhWR+us..sGph...LCNACGLaa+hpthh	.......Cs..s..C..t..osp.....TP.hW..R+..ss............sGph.........LCNACGLa.aKhps..........	0	638	1149	1789
+404	PF00117	GATase		Glutamine amidotransferase class-I	Sonnhammer ELL	anon	Prosite	Domain	\N	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.44	0.71	-4.85	134	29637	2012-10-03 00:28:14	2003-04-07 12:59:11	23	151	6931	113	7451	26546	18089	186.40	22	46.33	CHANGED	lllDshtuhptslh+tltphs......hplplh..s......pth........................psculllSsGPGsst........httthphlpphhp.....plPllGICLGhQhlshshGu......................plh..........................ptt.hshpGtsp.ltp..t............hhhshspshhstphHuhtls.....t.lsps..hplsshstss.......tlhulhcppt.....hhulQFHPEshhsspstphLhshhlph	...............................................................................................llDhh...tht.tslh...ct..h.t....p.hs..................s.p.s...p...l...h....h..s...t.....t.tph......................................................................hpscu..l....l.ls...s....G......P.G.s.stt.......................hpt.t...h.p.h..l....p..t..h.hp..............p...l...P...l.....l..GICL.Gh.Q..h...h.sh.t.h.Gs.....................................................................................plh...............................................ptt....h.s.p..t.G.t....s..h.....l.t..p...t.......................................................hh..h..s...h..........p.....s....h...h...s....h.....p.......H...u....ht.lst.................................hs.ss......hp....l....s.....u....p.s......p.s........................thhu.....h.......h.......c......p..................s.....p..........hhulQFHPE..h....t..t..s..s..t..s..h..p.h.Lh.shh...h....................................................................................................................................	0	2366	4699	6278
+406	PF02934	GatB_N	PET112_N; 	GatB/GatE catalytic domain	Finn RD, Bateman A	anon	Prosite	Domain	This domain is found in the GatB and GatE proteins [1].	23.40	23.40	23.80	23.90	22.10	23.20	hmmbuild  -o /dev/null --hand HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.94	0.70	-5.55	147	4153	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	3865	37	1215	3100	3120	280.70	48	60.26	CHANGED	Es..lIGLElHsQLsT.coKlFsssssp.aus.....p..P.NopssslslGh..PGsL...........................Pl.lNccAlchAl+huLALssc.I...sph..spFcRKsYFYPDLPKGYQIoQaphP....lspsG..hlc..lp......................pup.......+c...............................................................lt..IpRlHlEEDAGK.lHpts.................................thohlDhNRuGlPLlEIVo-P....Dh+oscEAtt....alpcL+pllpalulsDssM-cGolRsDsNlS.................l+......................Gp.....t...........hGsRsElKNlNSh+tlpcAlcaEhpRQhclLc.............................................................................................................................................pG..t....p.l.QETRtaDsspspThsMRsKEsApDYRYFP-PDLsPlhlscchl-cl	...............................EsVIGLEVHspLsT.poKlFss.....sssp...FGs............c......PNopssslshuh..PGsL....................................PV...lNcpsVchAl+huLALssc..I..s.p.p..stFsRKNYFYP.....D.PKuYQISQ......a....-....t....P....IstsGhl-.lp...............sGpp.........Kc...................................................................ltIpRhH.lEEDAGKshHts..............................................................shShlDhNRsGsPLlEIVoc....P....Dh....R....S....scEAhA....YlcpL+pllpalGlSDsp...M.......-EGShRs..DsNlS..lR..P...........................hGp..........pp............aGTRsElKNlNSh+hlp...cAl.c...YEhpRQhcl.L..c.......................................................................................................................................................s.G...G......p.l....h.....Q.ETRha.Dps........p...s....pThsMRs.KEsA.pDYRYFPEPDLsPlhlsc-al-p.h..............................................................................................................................................	0	421	796	1040
+407	PF02637	GatB_Yqey	DUF186;	GatB domain	Bateman A	anon	Bateman A	Domain	This domain is found in GatB. It is about 140 amino acid residues long.  This domain is found at the C terminus of GatB Swiss:O30509 which transamidates Glu-tRNA to Gln-tRNA.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.59	0.71	-4.49	103	3872	2012-10-02 13:42:24	2003-04-07 12:59:11	13	14	3640	37	1195	3139	2254	147.40	34	29.94	CHANGED	-aFEpslpts..ss....s+tsuNWlhs-lhuhLscpshslpp...................lss...ppLupllph....IpcGpISsKhA.Kclh.pphh..ps.stss.........cpllccc.GLtplo..Dpstlppllc-llspN.spt.lcca+sGKp....+shualVGQVMKt.o+G+A.s..PphVsclLpccL	..................................................................................................caFEts.lttu....ss......sKhsuNW..l..hs-lhth...L.N.p......p.s....h.s.lpc........h..........................sl.oP...ppLupl.l.pl.........I.c.-G..sI.......SuKl......A.K.c.Vh.p.t.lh........ps...usss........................c.p.ll-c...c.G..L....h.Q.lo.............D......s.....u...s........l....psh.....lc-l..ls....s..N....spt...Vc....c...a...+........s......GKp........+u.....hGalVGQlMKs....o+.....G...p.A.NPphVscLLppcL............................	1	410	790	1026
+408	PF03615	GCM		GCM motif protein	Griffiths-Jones SR	anon	PROSITE	Family	\N	25.00	25.00	31.80	34.40	22.30	21.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.60	6	146	2012-10-02 23:28:20	2003-04-07 12:59:11	10	1	79	1	94	148	0	139.50	68	28.86	CHANGED	caDcFsEWsDGaVRaIYuscDccA+KHlSGWAMRNTNNHNspILKKSCLGVllCSpcCpLPsGuplpLRPAICDKAR+KQQsKpCPNptCc.G+LElhPCRGHsGYPVTHFWR+sGpuIFFQAKGsHDHPRPE.sKsooEARRuh	.....................aDtFpEWsDGaVRaI.You.c.-+pAQRHlSGWAMRNTNNHNsp...ILKKSCLGV.VVCu.ps.CsLPsGs+l..pLRPAICDKARpKQQcKtCPN..Cs.GsLELlPCRGHuGYPVTNFWRp-GpuIFFQAKGsHDHPRPE.oKspsEARRu.h..........	0	21	27	55
+409	PF03074	GCS		Glutamate-cysteine ligase	Griffiths-Jones SR	anon	Pfam-B_541 (release 6.4)	Family	This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS).\	      This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).	25.00	25.00	27.20	25.20	19.30	22.80	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.37	0.70	-5.40	10	455	2012-10-02 17:21:26	2003-04-07 12:59:11	11	6	292	4	308	460	7	297.10	42	57.32	CHANGED	IYMDsMGFGMGCCCLQVTFQAsNIsEARaLYDQLusICPlhLALSAATPFaRGhLuDhDsRWsVISASVDDRTtEERGlsPL................psp.hcI.KSRYDSlDsYlSsss...EcYNDIsLsIscclY-pLl-sG...IDchLApHlAHLFIRDPLslF-EpIclDDssco-HFENIQSTNWQTMRFKPP.....PPcS.-IGWRVEFRPMEVQLTDFENAAYsVFVVLLTRsIlSa..+lsFhhPlShVDENMKhApcRDAlLppKFhFRKDI..Cps.s....hssKsssso--suE....MSIDEIING..KcGsFPGLIP........llRpYLEstclDsDTRC.lpsYL+hISKRAoGEl.TsAcWhRpFlssHPDYKcDShlTDcIsYDLlp+scpIAs	...........................................................................laMDuMuFGMGssC.LQl.TaQuts.ls-uRhlYDpLsslsPlhhALoAAoPha+G.als-.DsRWshIusuVDsRT.cE..h...u......Ph..............................................tp.t.................hI.KSRY..sShs.Yl....u..t.............p....................................p.Y...sD.s.lshs..pplhp.p.LhptG........hDchLAp..HhAHLFIRDPlslFpEplp....s..pp.....s-.HFE....................NlQSTNWQphRFKPP...........P.s....s.s...s...lGWRVEFRshElQlTDFENAAassFlsLlo+.sI.....L.s.a..........plsh.hlPloplpENMphApt.psAshp..t.hFaFR.c.s.....................................................................p............p..........................holspIh.pG......p.............t........s.FsGLls..............l.l...pp.a..l......p..p.h......p....hs......p...pt.................l.tYLphIppRAs..Gpl......TsApahRpFlhpHPtY+pDShlspplsaDLl.th.tl..t....................................	0	114	166	260
+410	PF03009	GDPD		Glycerophosphoryl diester phosphodiesterase family	Griffiths-Jones SR	anon	Pfam-B_4008 (release 6.4)	Family	E. coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted [1]. This family appears to have weak but not significant matches to mammalian phospholipase C Pfam:PF00388, which suggests that this family may adopt a TIM barrel fold.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.62	0.70	-4.88	34	9993	2012-10-01 22:17:21	2003-04-07 12:59:11	12	139	4031	48	2657	7515	2527	235.00	21	65.67	CHANGED	HRGsusphP...........ENTltuappAhptGADhlEhDVplTKDGhsVlhHD..........tplscssssss.....................hlpchohp-lpphp................................................tst....h.tpth........................sTLp-hlph.........hssshphtlclp.hsphhthpt....hstthsthh.phh..........tstplhhpoFphcthphhpphts.....phshhhLhptss.ths...........tthphhts.shhsththhsts.......................hlpts+ppG.ltVhsaTlsst..................tphthhhchGVDGllTDpsst	..............................................................................................HRG..s....s...s.....h..hP.............................................ENT........l........t...A.hp.t.A.........h............p........h......G...s......c.....hl..E..h.Dlp..............hT+...Ds...p.............lVlhH.....D.............psl...c....R...so.ssps..................................................................................hlp-.hTh....p.-.l.pplc..................................................................................................................................................................h.t..............h.....s..p..t.h.................................hsoLc-hlch...................thp..h..t.h....t..l....c....l..c..............h....s....t.h.h.t................................t.h.h.......t.........h.h.....t.....hh................................................................................................................t....p...........h.h....lp..S..F..s...h.p...l.pth.pphts.......................ph..h...s..h...l.h...t........t.............................................h.t......h...t..t...........t..h..h..h.....t..h.t.......h.s...h..............................................................................................h...l.pt..h...+.p....t..s..h..l..h........s..a...Tlsp......................................t.ht.h.h....h.....p...h...s.......l......c....u.lh.TD.st.h..................................................................................................................................................................................................................................................................	0	842	1578	2169
+411	PF00626	Gelsolin		Gelsolin repeat	Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.46	0.72	-4.29	54	5387	2012-10-01 21:06:05	2003-04-07 12:59:11	17	133	440	183	3048	5007	35	78.00	19	21.63	CHANGED	ph..s.ss.hstsplpsscsallDssh...........plahWhGpp..ss.tcpshus.hstplp............pph.shs.hhp.spu...pcsspFh	................................h....s..s.hsts.pl.ps..s....D.sa..ll-.sst...............................................................plahWhGpp..........ustp....E......c......t......t.........u..h..h...hs..tplp..................................pphts..h.....s...hhh....pG...tEs.tF.............................................................	0	854	1348	2192
+412	PF01408	GFO_IDH_MocA		Oxidoreductase family, NAD-binding Rossmann fold	Bateman A, Griffiths-Jones SR	anon	Pfam-B_342 (release 3.0)	Family	This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.62	0.71	-3.59	52	20348	2012-10-10 17:06:42	2003-04-07 12:59:11	17	96	4230	256	6149	17689	10023	120.50	24	33.45	CHANGED	h+lullGs.Gth...upha...htshhps.pth.......clsulhs.sttpucth....upphshs.....sass..........hp.plhsps..c...lDslhlssPs......th....HhphshthLptGh..aVlhEKPlsh......ohp-spclhphsccps..........hh.ltlsa	....................................................................................................h+lullGs....G...th.............up.t.a.........h.t..s...h..h..p..t......ssh................................cl.s..u..l..s..s....h....s.........p....p....s..p.t.h................................up.p.h....s..ht..............hh..s.s...................................................................hc...cllsps.........p.............lD...sVh.l..s.oPs.............sh.......Hhp....hs..h...tA..lp........u..GK........HVh.....s.....E...K...Ph..uh..........shp-..sc.c....l...h....ph...Ac...c...p.s....hh.lhh...............................................................................	0	2220	4074	5250
+413	PF02894	GFO_IDH_MocA_C		Oxidoreductase family, C-terminal alpha/beta domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_342 (release 3.0)	Domain	This family of enzymes utilise NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.	20.80	12.60	20.80	12.60	20.70	12.50	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.30	0.71	-10.30	0.71	-4.29	37	12324	2012-10-02 13:21:44	2003-04-07 12:59:11	12	35	3630	193	3449	9524	4058	106.70	15	29.99	CHANGED	+chlppst.lGplhhhp..thhtspttt.spht.p............suGshh-huhH.lDhhphLhGt..spss...shh..hphsptsphtsst.......................hshthssht....ssthssshspshshphhhh	.................................................phlppGt.lG...c...l...h....h....h.....p.................h...........t...h....h...............t.......s...............s......t...h....t....hp......................tuuG...s...l...hD.hu.sHhlDh......s...h.a...l....h....G.........p.............s.....p...h...ss..............sh..............h.......h...........t..t....t............s.........................................................................h.h..........h..............................hh..........................................................................................................	0	1200	2256	2931
+414	PF00990	GGDEF	DUF9; 	GGDEF domain	Bateman A	anon	Pfam-B_112 (release 3.0)	Domain	This domain is found linked to a wide range of non-homologous domains in a variety of bacteria. It has been shown to be homologous to the adenylyl cyclase catalytic domain [1] and has diguanylate cyclase activity [4]. This observation correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.97	0.71	-4.65	49	42746	2012-10-01 23:51:22	2003-04-07 12:59:11	16	1972	2995	26	12809	36762	3058	153.10	28	27.32	CHANGED	AthDsLTsLsNRphhpppLppthpps.tp....ppthullhlDlDpFKplNDpaGHpsGDplLpplAptLppslRp....sDlluRhGG-EFsllLspss.p....stphtpthcphlpphphsh.thsshth.lohSlGluth..........tpspshppllcpADpALYpAKppG+Np	.......................................................pDs.LTG.LhNR....p....h...h.p.....p...p.......l........p.......p.......h...h.........p.......p.....s......tt....................t..p.......t.....h.....u....l....l....h....l..Dl...D.p.F..K..p....l....N....D.....s..a.G....H..t..sG...D.....p.....lL.p.pl.A....p.t.l...p....p.......t......l......c...........p................s-..............h............l.............u...............R..............h......G.........G....-........E..F...s.....l...l..........l.........s.....s...s......s...t.p........................p.........h.....t....p.....h.........h.p....p...h...l...............p...................t.............h.........p...................h..............................h.................................................t............t...........h..............t...................h........t.................l.....o...s......S..l..Gl....u..h.h...................................p...s.....p......s.....h.....p....p....l.....l....pp...A.D...t.Ah.Y.p.A.KppG+s......................................................................................................	0	3883	8047	10652
+415	PF03321	GH3		GH3 auxin-responsive promoter	Mifsud W	anon	Pfam-B_3652 (release 6.5)	Family	\N	19.60	19.60	19.60	19.60	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	529	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.79	0.70	-5.99	64	945	2012-10-02 15:58:18	2003-04-07 12:59:11	8	9	449	8	439	940	720	439.50	24	91.84	CHANGED	ctlc......p..h-pht....................psst...plQcclLpclL.ppsssT-ah++ashp......uh..hs........c..........FpppVP.......lhsY--l.cPaIcRltsG-........ps.llhsps.lphFstSSGTouupsKhIPhoc-.lcphphhtuhthhh..hppphssh.hpGK..hLths...sphppp..GhhhGsloshhhc..s.h..hp............hhpsPsptlht.-sapshhppllpthh.cpclttluul.uhhllhhhchLEpphpch...........................................................ltclWPshc.lhshsssuht.Yhtphcthhsu.h.hh.psYsuSE.Gahulpsp....spcsuhhlh.shu.aaEFlPhcc.t............................sphlsLs-VclGppYtlllTThuG...................LaRYplGDsl+h.Tuhpst..plphssRpphhlslhu-+hstcclppAlppu....h.ptt.....shpls-aT.st.sp.h.stsu+ashhW.lpsc......st.........................shp..phsptlDpuL...NssYctpRptshplsslcl+llptGsFpchhc.thu+.Gu...QaKsPRhs..sspph..t...l	.........................................................t.....hp.hh..ppst...thQpplLtpll.ppstpopahp.pa.tht...............t.h.shp.................p..........FppplPlhsY-ch.pshl.pR...h.hp.Gc................ps..ll.h.st.....lhhahh.o.S...G..........To.ss...t...KhlPhspc....hpphp..hshth...hh...........htp...s......p.G+..hh.h.....th.p...ss....h...ht.shts.....h..h..p...s.h......hp..............p.Pst........h...h.....sthp.p.h..httlhpthh.ppplthlu...uh.s.hhhhhhchlp.t.....phpp.h..........................................................................................................htcl..WPphp.l.hhssssht..Yhtph.c.t.hhs....t..h.hh.phYsuSE.u.ah.uhp.p.............................pp..s..s..h..hlh.shu..aaEFlPhcp.t......................psphlsLt-VchGppYtlllTT...uG...........................LaRYplGDslch.suh....t.s.....t............phphssRpph..hlsh.u.-c.h.tpphppAlppu.........h..t..........shplh..-ao....sh.....s........t...............................st...........s..c..........hhh.W.lpht......sp.........................shp...phsthl-ptL...sssYcttRht.hsltslclphl..p.ts..h..Fpphhc..hsp.Gu...QhKhPRh....p.......t.........................................	0	135	318	377
+416	PF00288	GHMP_kinases_N	GHMP_kinases; 	GHMP kinases N terminal domain	Finn RD, Mistry J	anon	Prosite	Family	This family includes homoserine kinases, galactokinases and mevalonate kinases.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-9.32	0.72	-3.91	455	15529	2012-10-03 01:04:38	2003-04-07 12:59:11	21	62	4900	114	3877	10927	3091	64.70	24	18.95	CHANGED	clpl.pssl....Phu.uGLGSSuusssuslhu....lsphh.....s....h.s.............l........sp............pl...hphuhtsc..........tGsss....ssshhGs	....................................lplpssl.....P.h.u.uGLuSSuushsusl..hu.....hsphh........s...........h..s............................................L........sp.................................pcL.........hphu.t...ts..E............ts..ss..ssshhG..............................................................................	0	1260	2384	3266
+417	PF00594	Gla	gla; 	Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain	Bateman A	anon	Prosite.	Domain	This  domain is  responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).	20.40	20.40	21.20	20.40	19.90	18.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.92	0.72	-4.27	29	998	2009-01-15 18:05:59	2003-04-07 12:59:11	15	54	109	47	394	801	0	41.10	45	11.04	CHANGED	lEEhctGslEREChEEhCshEEApEhapss.tTptaap+Yhs	..........hEEhppGsLEREChEEh.CsaEEARElFE.s.sp.cT...pt.FWppYh................	0	28	60	159
+418	PF00208	ELFV_dehydrog	E_L_F_V_dh; GLFV_dehydrog; 	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	Finn RD	anon	Prosite	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.48	0.70	-4.80	124	6466	2012-10-10 17:06:42	2003-04-07 12:59:11	16	23	3999	221	1773	5816	1828	223.60	33	52.44	CHANGED	GGS.hsRscATGhGlhahscchhcp..ttp...plcGppVslpG..GNVutasschhhch.GA+lVulSDupGslh....c.sGl......clptlhch.+pppts..lssas.............c.hh.ss..p....................ht.......l.......csDlhlPs.AhpNplstcsAc.hl.....+.......s+hlsEGANhPsT..-Ahc.lhpcpG..........lhhsPshhANAGGVssSuhEhsQN.tth.WopEcVsp+Lcpl...........Mpshacsshptupc..hshs........hhtuAslhuhp+VAcAhtspG	.........................................................GGS..hsRscATG......hGlhhhsc......phh..cp....shs...................h.cG..t....p.V...s...l...p.G...GNVutas.s..c..h..h.h..........p.........h...G..A..........+..V....l..s..h......S.....D......u.....s.......G...h...l.h......s....s...Gl........cl.stLh..c....h....+pppts........lspas......................thp.hh...p.st....ph..............................................................ap........h.......psD.lhlPs......A.h.pN.plst...c.s.A.p.hl................................p.....................s...phVsEGAN..hPo.T.....-.A.....h.........c...lh.p..c..p.G...............ll.hsPshsuNA.G...........G.......Vs.s.S.h..h.EhsQN..........t.h.W..s..t..-cl..pt+Lcpl..........................................Mtshapt...s.h.ph.u.pp...ths.................hhhuA.hhuh.+lspAhh.pG......................................................................................................................	1	635	1175	1539
+419	PF00042	Globin	globin; 	Globin	Bateman A, Chothia C	anon	Structure_superposition	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.33	0.72	-3.71	73	6000	2012-10-01 21:46:00	2003-04-07 12:59:11	17	34	2886	1971	1261	5331	34	99.80	25	43.59	CHANGED	ppthlpssWsp.lhs......ph.thGschhtclFpsaPps+shFsph.ts.p.....tsssphcsHut+Vlsulspslspl.....s.slpstlppLuspHtpct....lssspFphhtpslh	........................................hshlpsshsh.ltt................pssch.ssch........h..t....R....hF..t..saPp.s.p.p.hF..s....ph..........s.t...................ss..t.phpspu..ppl.hs.ulsphlppl..................sl...t...sslppL...u.phH...sshh........V.cPppapllupsL.................................	0	348	594	949
+420	PF04898	Glu_syn_central		Glutamate synthase central domain	Bateman A	anon	Pfam-B_455 (release 7.6)	Domain	The central domain of glutamate synthase connects the amino terminal amidotransferase domain with the FMN-binding domain and has an alpha / beta overall topology [1].  This domain appears to be a rudimentary form of the FMN-binding TIM barrel according to SCOP.	21.50	21.50	21.60	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.48	0.70	-5.15	37	3372	2012-10-03 05:58:16	2003-04-07 12:59:11	9	34	3044	15	950	2992	3369	283.90	42	18.60	CHANGED	lhppQpAFGYThE-lchlltPMAcsGpEslGSMGsDoPlAVLSc+s+hLYcYF+QhFAQVTNPPIDPlREp..........lVMSLpohlGscuNlLc.sspp..s+plpLcoPlLsps-............................hpp.l+sh..........pthpstslshsashp....pu............................hpu.LcsulcplsppAcpAlcsGtslllLSDRp........hstp.+ssIPu...LLAluAVH+HLlcpslRscsullVEou-sR-sHHFAsLlGYGAsAlsPYLAhEolpp..htccshh........phshppshpNYp+AlspGllKlhSKMGISTlsSY+GAQIFEAlGLup	.................................................h.phQptFGYotE-lchlltsMupsG...pEslGSMGsDoPlA..VL.S.pc.s..+hLacYF+Q...hF...AQVTNPPIDs.lREp...........hVhSLtohlG.t.-.h.......N.l.L.s...........st..tp.........s+...+l.plpsPlLsp.s.-...........................................................................................................hpp....lpshpp................ppac..sppl..sh.sasss....................................................................................tps...Lctulccl..ssc.A.ppA.V.c.....s.G.s.s.lll.L.SDRs...................l.s.p.s..+hsIPu...LLA.luAVHp+Ll.......c.......p.......s......LRs.psullVEoGpsR-sHHaAsLlG.aGAsA.l.s....PYLAaE.oltc.........hhcpttl...........................sh.s.h.cpshpNYtculsKGlhKlMSKMGISTltSYpGAQlFEAlGLs.p...........................................................................	1	289	615	816
+422	PF04960	Glutaminase		Glutaminase	Bateman A	anon	COG2066	Family	This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2.	19.80	19.80	19.80	19.80	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.78	0.70	-5.43	17	2528	2012-10-02 21:13:33	2003-04-07 12:59:11	10	25	1760	57	544	1601	173	277.00	43	80.87	CHANGED	GpVAsYIPtLA+ssssphGlulsssDGphhpsGDschsFolQSISKVhshslAhtchGtc.lap+VGpEPSGpsFNSlstLEhcp.uhP+NPhINAGAlsVosllpucss.t-thphllphlcplsGspplshsptVhpSEhpTu.RNtAlAaah+phGshpp-l-...ssLchYF+tCulchoCpsLAhhushLAssGhsPhosEpVlstchs+phtAlMhTCGhY-sSGpFAa+VGLPuKSGVuGGIluVVPs..........hhululaSPsLDchGNSltGsthLcpLuphhshSlF	.......................................GclADYIPtLApV.s.ssphGlAlsT.s.D.G.p.h.a.p.A....G....Du.....chp.Fol..QSISKVhoLslAhpc..h..Gtct..lap+VGt-PoGp.sFNSlltLE..h..cp.GhPpNPhINAGAlslss.h..l.......p.......u...........c..h.......s........p........th.....pclLchhcpLuG........p..p....l..shsptV....spS.Eh.p.p.u.t.RNtAlAah.h+..oh..G.h..p..s..Dsp..........psLcsYh.+tCulphssh-LAphushLAstGh.s.Ph..s....s......c.pV.lss..pp.s+plpAlMhTs..G..hYstuG..-F.Aa...............+....V...G.LPuK.SGVGGGIlAlVPs...........phuIulaSPtLDpt.GNS.ltGhthlc.p....Lspph.Ghsla..............................................	1	146	287	427
+425	PF04488	Gly_transf_sug		Glycosyltransferase sugar-binding region containing DXD motif   	Kerrison ND	anon	DOMO:DM04307;	Family	The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other  sugars, phosphates and proteins.  DXD-containing glycosyltransferases all  use nucleoside diphosphate sugars as donors and require divalent cations,  usually manganese.  The DXD motif is expected to play a carbohydrate  binding role in sugar-nucleoside diphosphate and manganese dependent  glycosyltransferases [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.52	0.72	-3.63	22	1796	2012-10-03 05:28:31	2003-04-07 12:59:11	10	51	807	0	967	2109	434	94.40	21	24.68	CHANGED	spchhtshcohh.phpP-...hphhlhscpht..............................shphlhpp.ss.......hh.phhs......hh.h.hthuDhhRhhlLa+YGGlYhDhDshslpsl.......sslhsppthh	.................................................................................................................................................................................hpphh..phpPs.....aph.h.h.hscp........................................................................................................................................h.thh..hpp..hs.............hhpsap............p.h..h....h.h....tuDhhRhhlLa....phG.GlYhDhD.sh.sl+sl.......s.hh......t.................................	0	321	557	794
+426	PF00722	Glyco_hydro_16	glycosyl_hydro9; 	Glycosyl hydrolases family 16	Bateman A	anon	Pfam-B_759 (release 2.1)	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.48	0.71	-5.00	120	4255	2012-10-02 19:29:29	2003-04-07 12:59:11	16	172	1239	83	2173	4494	761	179.30	18	46.71	CHANGED	hsppass.sasssps.h........s.......tslsLslc+......................to.GushpS...pptahaG...phpsplK..supusGlVouFal..s...o.ts...sspDEIDh.EFLGs.sssp......lpTNha....spGpus......p....E.phhh...haDso.psFHsYulhWssspIhahVDGhslRphpppps...s....s.a...Pp.pPMp.lhso..lWsus.......sausptG..........hhphDWst	..............................................................................................................................t......h......ts..........h.l..thtp............................................hs...uutlpo...............ph.p....h....h.....a...G..............p.h...c.s..p..hK...........hst.....u.s...G.h.....hs.A.hah......p...................s............s..s..ps....E...IDl..E..h.......l.......Gs..p.ssp............................hp.s..s.....l..a..................sp.u.tss......................................p.........ptp.h.h..............h.....s....ss....s.saH.....s.....Y.....s.....l.........................W.......s.........s.......p........p........l..h...a....h.l.....D....s.........t.........h.t.....p....hpttt................................a...........P............ht....l....h...h....s........a.s.ut..................t..........................hta...............................................................................................	0	645	1357	1879
+427	PF00704	Glyco_hydro_18	glycosyl_hydro8; 	Glycosyl hydrolases family 18	Bateman A	anon	Pfam-B_574 (release 2.1)	Domain	\N	29.60	29.60	29.60	29.60	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.36	0.70	-5.00	165	8946	2012-10-03 05:44:19	2003-04-07 12:59:11	23	253	2235	288	3234	8695	370	279.40	18	59.57	CHANGED	tpllsYas....pau.htts..................h.hppls.......pthoHlhauFsslssssth..............................................................tt.ststpsthpphspl+..ppss..slKlllSl...GGht.us.............sasthstss......pt+pt.FlpSshphlppat.....................hDGl.DlDWEassst...............................ctpsastllpcL+pthpp..........................phhLosA..........hssss....hhpth...shsphtph.lDalslhsaDahu......htt......suhpssLasss..............................................................hssp.slphahpts.ss.spKl.hGhshY.upuaphsss..t...............................................s.ttuhhsapplsphh.........................tht.thsss.spss.ahhps...............h..lsa-sspohttKspahpptslGGlhhWsl.s.hD	........................................................................................................................................................................................................................................h.sh.h......h.sh.h......................................................................................................................h..t.....h....t...ht.....t.......th..p...h.h....h...u.....l............G..Gh....tt.........................h...t.h..s.t.s.t...............tt.tpt..a.hp..shh.p.h.h..p..p..hs......................................................h.D..G..l...D............l...D....aE..hssst....................................................................stps.as.hL.lp.....pl+.pthsp.................................phhL.o.h..A...........................h..ss.s.t...............hhpth......ph......t.....t....h........s....p.......h.....l...............D......a.ls.l...M..sY....D...hhu.......htt................ss..ts..s..lht.........................................................................t...h.p.......s.l...p...h...h........h...t........t...s..hs...sp..K..lhlGh...s.ha..s..h..sat................................................................................................................................h............................................................................................h.....h...................................h.....h...s......h..p...........................t.h...G...h..............................................................................................................................................................................................................................	0	1050	1817	2735
+428	PF02055	Glyco_hydro_30		O-Glycosyl hydrolase family 30	Mian N, Bateman A	anon	IPR001139	Family	\N	20.20	20.20	20.50	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.55	0.70	-6.30	3	1151	2012-10-03 05:44:19	2003-04-07 12:59:11	11	52	589	84	517	1057	187	328.70	21	77.79	CHANGED	AsDCspKTF.KTGlVCVCNlTYCDEI.PPlslshGQAApYTTS+SGARLHRDVlYATso-PhToLHhTIDSSKKYQTIQGFGSTFSDASGANLKSLPDphuDLILKQYFSDoGLNLQFGRVPIASsDFSuRVYTYsDss-DYsMpNFSLs+EDaQWKIPYI+pAQKYNpc.LKLFAuPWoAPGWLKTTsussGhGuLpGpsGDsYHQoYA+YFV+FLEEYuKsGIpFWGLSTQNEPTuGSDKKsKhQShGFTAEaQRDFIKpDLGPALAuSouGKNVKLLILDDNRGNLPKWADTVLNDhDAAKYVuGIAVHuYQD..uEoDsHLsETH+pHPNsFIFGTEASEGSKSKDppVDYGSWDRAtDYuSDILDNhNNWVTGWTERNLlLDApGGPSWVSsFsDAPVIAFPAhAQFYKQPMFYAIAHFSHFIKPGAVRIDHSLNhhN.ElEsoAFLNPDGSKVVVlLNKuSLsss.aoLoIKDsAcSpsHYphTLSP+sIlTLYIQ	..........................................................................................................................t..........................................................................................................................................................................................................l....l..........t...p..h.Qp.h...GhG..ss...hsttsh........h.......t...h.......t.....p..t...........hh.......p.........ha....s..........................p.................t.......h.thshhR......h........sh.......su....s.....D.h..s................t..............a..s.h..........s....c.................t..........D......t............h.....t....p.....h...s......h...................................p......t..........................l...s.hl.p....t..h.......................t......h..........s............t....h.p..lh.u.oPWosP....saMK......s.......s...t............t.........h...........................................................s...................h...........................................................................................h......t..........s..........aApYh.hcal.pt.h.t.t.p.Gl..h.slohpNEP....................................h...s...hhhsst.....t..tta...hht....LtP.t......ht...tt................t.htl..........h............h..........h.....-.........p..........p..................................................t...............h..................................h......h..t.p......t...........s.....p...h..h.tGhuhHhY....................................h............h....t..h.P..p.h.......hh.oEt.......................................................................................................................................................h.......h..h...t.....h.....h..........t...hh..Wshhh....p....................s..........t...........................t.....................t........h.......h..............t............t.........h.....h.....p...........a.Y.hhuphu.+al.....G...u.p..lt.............................................................h................suh......p..s......-.s.p.h.s.h.l.h.h.N.t.t..........................................hh......................................................................................................................	0	224	348	456
+429	PF01055	Glyco_hydro_31	Glycosyl_hydr15; 	Glycosyl hydrolases family 31 	Finn RD, Bateman A	anon	Pfam-B_369 (release 3.0)	Family	Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null --hand HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.43	0.70	-5.66	107	5543	2012-10-03 05:44:19	2003-04-07 12:59:11	21	109	2144	97	2001	5559	314	398.50	24	54.47	CHANGED	YhhsGs...................s..s.pcllcpY.sploG..........+ssh.PhWuh.Gaap..sRasY..........ps....ps................................................cltplsppaccpsIPl-shahDh-..............Yhc.shc..sF...oactppF..........P......................pscphlccL+.ppGh+hlshlcP.........slptsps.......h.sapcuhppsh.al.......+.pssG.p..................hhuts.Ws.....................s.........ssasDF.....hsP.c.sppWW.tsphpp....hhsp.........ul-uh.WhDhsEsus..........h...........................................................................................................................................................................................................sh.shsshphsss............pphchHNlYuhhhspusacu..lhp..h.psscRsalloRSsasGup+auut.WoG......Dst.usW............pslph...olsthLshu.lsGlshhGsDluGFtus...........sst.....ELhsRW.hQhGuFhPahRsH.sshs....sptp..................EPahasp....spshh....+phlplRYpLLPYlYohhhcupps.GhPlh.RPLhhcaPp.D....tpshs.lccQahhGs.s...lLVuPVl.................pps.ssphpsY.LP......pG..p...Wa-hh......stcth....puG..p...hlp..l.suPl..splPlalR..sGsIl	...................................................................................................................................................................................................................................................hh.G...p.....ttlhppa.tt.lsG.............ps..s.h...P.h.a.......u........h...Gh.h........sp.hth.................s.....pp...........................................................................p.l...p.hh.ct..h....p..p..t...s..l.P......h............s...s.h....h.hDh.......................................................ahp...shp..........sa................p.a..s.....t..pa..............................P..............s...p.thl.p.p.l..+..p..p.G..h..+.h.h.h.h..l...p.P........................hlttpps......................a.pc..h.h...p...p...s.h.hl.................p..p.pu...t...........................................................................................h....h...th...a.........................................................................................s........ssh...D..h.....hs..P....p...stp.a.a..t..p..h..h..p..t.......hhtt...................Ghs.s.h.h..h.................Dh.s.E...........................................................................................................................................................................................................................s.ssh.h.h.ss...............p..p...h..+N.h..........a.s..h....h................h..s..ps..shps................htp........................tp.....csh....l.hs......R.........u........u.h...s.Gsp+.a.......s.sh....W..sG...............Dsh....ss....W.....................ps..ht.pl.ts.Lshu.hsG.h.s...............h.h...........u...tD.l..G..GF..ss.....................sst................................ELh.h.RW.h.phG....s.a....P...h.h.Rh..H....s..s.s........t.........................................-PW..a.spt.............stsh..h..................+ph....h....p....l.R.h.p.L..h.PYlYshhh.p.....s......p.......p..p........GhP......l.h..RP..h...hh.c...asp....D.....................t..s.h..p.....l.........p.....p.............p.a........hh.Gs..s..................l.LVu.PVh.....................................pts...t......t.....p......h...ph.....Y..LP........pu...p...............W....hchh.......................ss.p.th...................pGu...p..............hhp...........h.tssh........t............p........l.P.l.ah+sssh..................................................................................................................................................................................................................	1	765	1179	1663
+430	PF01532	Glyco_hydro_47		Glycosyl hydrolase family 47	Bateman A	anon	Pfam-B_958 (release 4.0)	Domain	Members of this family are alpha-mannosidases that catalyse the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).	20.40	20.40	20.40	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.47	0.70	-5.83	139	1956	2012-10-03 02:33:51	2003-04-07 12:59:11	15	40	313	21	1367	1890	72	398.90	31	70.19	CHANGED	hFh+uWsuYtc................aAaspDELpPlSpss.............pss..........................h....s...shGhTlVDuLDTLhlM...........shp..................cEapcuhcalt......ppl..s...............as.................st.t...l...........slFE...........................TsIR............hLGGLLSAatL..o...............................................tcsh..................lLc+Ah-L.u-pLh..sAF.pT..s.oGl.......PhsplN........................l.........tp...st.t..thsst.........................................................ts..s.....h.AchGoltLEFsh............LSpLTG-spYhchsp+shphlhp.........ttp...GLhPhhl...sspsGpas.t..............................................................................................................................................................phslGutuDS......aY........EYLlK.........talhh..u...t...p..................................p............................ahchap...........................puhpulpca.hhp.......t.............thhalup.....h..............t...th.hps...ph-HLsCFhuGhhuLuuh.h..........................sclchA.pclscsChphYpph..oGlhPEhhphs....................................................................s.......thhhp........................................................................................................................................................................tstpYhLRP..............EslESlaahYRhTsD.pYpchGWchapulpc.ts..+s....ps.............................GauulpDVp........................sp............hpD..........................pMESFa..LAETLKYhYLL.Fs...........-ssh..ls......................LccaVFNTEAHPl.h	..............................................................................h.puapsYhp..................a.Aa.shDEL.pPlo.p.ps................................ps..........................h......ssh.uhTl...lDuL..D.TLhlh............s..p...................p-Fpcuhph..lt..........pl...s....................................as............s...t...l........slFE...........................ss.I.R..........................hlGG..LLoA.a.ls...............................................................................................................tpt.hLphAh-l.u.p.t.Lh..sAF..p...T.s.ou...l...........P...h.s.hls...........h.......tp.t.h.........sst.....................................................................................ts......h.Aphuol.lEFt.h..........................LSpl.TGssha..p..hs..p..p.....hhp.hl.p................G.Lh.s..hl......ssp..sG.pah...t...........................................................................................................................................................................................................................................................................................................................................................................................................................................tphslGu...hsDS....................aY.....................EYLlK............talhhs............c............................................................tt...........................hhpha...........................................pu.h.p....ul.pahhht......s...............hhhlst.hp...............................th.hp.h.hp.p.Lss..F.hsGhhsLu.....................................................tp...h.p..hAhpltps..hhth.a............pph...shhPEhhpht.................................................................hp.........................................................................................................................................................................................................................................tptha.L....R....P........E..h.lEShahh.a..R.h....T..t....D..........h..Yhc.............hGh..p......hh..pu.lpp..hs..+s..ts.....................................GauulpsVh..........................s..sp......................hpD..................................................p..h-......SFaL.......uETlKYhYLLFs....pss........ls.............................................................hspaVFsT.....EAHsh...........................................................................................................	0	462	748	1108
+431	PF03200	Glyco_hydro_63		Mannosyl oligosaccharide glucosidase	Mifsud W	anon	Pfam-B_2589 (release 6.5)	Family	This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyse the specific  cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway.	19.00	19.00	19.00	19.00	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	801	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.88	0.70	-13.48	0.70	-6.70	15	722	2012-10-03 02:33:51	2003-04-07 12:59:11	11	9	421	0	454	910	161	431.20	23	58.05	CHANGED	lsllhlu..htshhhhthhhst..............+slssasss.h.p.s..hpsttssshaWGoYRPplYFGlRsRoPcSLlsGLMWhs...s.tsGtsslRHh..CEQGD.sLssYGWhcHDGRsFGpQcIpD.ps.hsLpT-FVKp.t.t..aGGDWusRIpupspsusps.s......psSLhaYsusEGps.....slsscl.stpspls........................hloGpop-LGpFplpl............ps.sss......hhcspahuhpsPs...lhplpD.......................lVhpsLppphpp....hss.t..tphlslss.h.........pspppuNllhh......QlohpsshphDIlFpSusstcpsp.............LTGpslsspLcc+pppF-cKFpppFsLppKh...............hsssphpFA+sALSNhLGGIGYFYGsSlVp.......................puhpptcslhYhPus..........LaTAVPSRPFFPRGFLWDEGFHpLLlt+WDscloh-lluHWhsLlNs-GWIPREQILGsEARSKVP-EFllQpspsANPPTLhLslccLl-shcsst..t..................................thhsaL++laPRLcsWFpWFpsTQ.pG.l.s..........oYRWRGRshs....LNPKTLsSGLDDYPRASHPossEhHVDLpCWhuluopsMsslAchLGpscshtc.......ptts.lssN..LschHWu-cppsYsDaGsHTc...................................tVtL....s....t.............h.R.s..hptPphphV.sphGYVSLFPFLL+lls.sDSs+LcplLclI+DscpLWosYGLRSLS+oushYhp+NoEHDsPYWRGPIWINhNYLhLpuL+HYu.....phsGPapspApplYpELRsNLlsNlh+QYppTGalWEQYDDp.oGcGcGs+sFTGWoSLVlLIMuEpY	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.hh..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..........t......h............h.h....h..............t.h.h...............s.........p................+L..........t.plL..p.hhhD.p.c.h...hos.....aGlR..SLS...+..............p...............s.....................h...............a....h.............p........t.............p..........s.......................................................................Y...................WRGP.lWhshNaLhlcuL.t.c.at.......................h.s.....................................................................................................................................................................................................................................................................................................................................................................	0	176	289	401
+432	PF03648	Glyco_hydro_67N	Glyco_hydro_67; 	Glycosyl hydrolase family 67 N-terminus	Finn RD, Moxon SJ	anon	CAZY	Domain	Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the N-terminal region of alpha-glucuronidase. The N-terminal domain forms a two-layer sandwich, each layer being formed by a beta sheet of five strands. A further two helices  form part of the interface with the central, catalytic, module (Pfam:PF07488) [1]. 	22.00	22.00	22.10	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.72	0.71	-4.08	38	324	2012-10-01 20:56:08	2003-04-07 12:59:11	9	8	239	17	133	354	23	111.20	22	14.45	CHANGED	sWLRYt..lsssth..phpshsspIVslsso..sslpsAtpELppGlpullGpsh..p.hssphsppss.......lllGThcshph.....ttshsp....Lss-Gahlpo....tpspllIsG.ps-pGsLYGsFca	...............................................................t.lh.h..tps.......................sslphAhpELppslptlhGpps...t...lh.s.p.ssppss............lllGohss..h......tth..t..h....s..t....t...ht....p...l....t..p....EGallps....................t.............s...pptllIsG.sscpGsLYGsach..............	0	49	88	115
+433	PF03663	Glyco_hydro_76		Glycosyl hydrolase family 76 	Finn RD	anon	CAZY 	Family	Family of alpha-1,6-mannanases.	20.60	20.00	20.60	20.00	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.64	0.70	-5.08	90	1340	2012-10-03 02:33:51	2003-04-07 12:59:11	9	29	493	1	758	1302	51	320.60	20	73.21	CHANGED	Sl....csAAsplAtshh.saYpGsp...G...shsGhhsss.......haW......WpuGuhassll-YWhh....TG..s..........soYNcllppulhaQsGps.........c.ahPsNtops...GND..DQuFWGlAsMsA.AEtsFsss..sst.p...WLsLAQuVFNs.s.sRWDsp....s.CsGGLRWQIasas.sGYsYKNolSNGshFpLAARLARYT..sNp..T.Ys-WA-KlWD.Whts.ssLl.......s....sp..apVaDG.s.....ssssN...C.os..hsph...pWoYNtGlaLsGAAaMYNh........T........pu...s.......tWpsRscslLsu..sh.....sh..F..Fsss...........lhhEh.uC......Es........t.p....CssDQtsFKuhhuRaLuhTstls.P..Th...-...pIhshLpsSApAAA.ppCoG...................us..ssp...hCGhpWh...ts.a.....DGhh.G...lGpQhuALpslpuhll......t.ssshoss	.......................................................................................................................................................................................s...........................h...................W.tuth.hs....s......hlchh.hh......tt...s............................sphp.p...h..htp...thh.hth..stt............................h.s.h......s......s......t..............h......D....Dtsa.......hu.l.u......hhp....u......hc..........hshsp............p..........a.L.p.hAp.tl..asphh...s....tWssp..................s.......G..Glh.W.............p.................................p.......s.......h.....saKNs......h.........uNush...h.h.u.u....+....L..h.p........h.................s......tsp...................p..YhchApch.ac.Wh..tp......sll.......ts......pp......hh.l..hDGh........................phps.......s.tp.....hsp.h.........paoYNpGsh.lsus.s.l.aph.....................T................ts..s.....pah..p..csptlhps......sh.......................ph......h...h.ss.............................lh.p...................................................sssD..t.t.....F+uhhhRhhs.hh......phh...s...t....p............................thhsh.lttsupssh........tt...........................st.....hhuh.W.t.................................................................s............................................................................................................................................................................................	0	203	429	641
+434	PF03644	Glyco_hydro_85		Glycosyl hydrolase family 85 	Finn RD	anon	CAZY 	Family	Family of endo-beta-N-acetylglucosaminidases.  These enzymes work on a broad spectrum of substrates.	36.00	36.00	36.50	40.30	31.30	35.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.04	0.70	-5.30	36	655	2010-01-08 16:09:57	2003-04-07 12:59:11	8	45	559	13	183	522	4	304.40	35	29.23	CHANGED	hhusYt..ssph.......spGs.sph...sYs.FtaWphlDhFVYFS....H.....................thlslPsssalssAH+pGV.VLGT.....lhh...EhssthpphcphLp.sppus..hhh...........A-+Ll-luchYGFDG.WhlN.Essh.s.......................stspphhsFlphLpcphpp...........t...............hlhWYDu.hT.cGplpWQNtLsppNthF................hpssDuhFhNYtWst.....................................pp......lctStphApshshs.hc............lasGlDVauRu..............htuthpsptslcph.......t..psphSlulFAPuWsac.........................spFhpp-spaW.......................................shlsp...................................lsF.hTsFspGpGtpaah	...............................tsuhs..psph.............s.Gs.pp........uYs.FsaWQYlD.hVa.Wt....c..........................GlV..Psssh.l....sAu.HRNGVs..V........hG.T...........laF.............sas..s....u..h...t.....htph...L...c.....p...c.scus...asl.......................AcKLV-hA+aaGaDG.aFINpEssss.............................shspphppFhhYhpchutp......h........................................ph.WYDu.hT.ssth.aQs..u.Ls.-hNh...F................h..ss.DshFhNasWsp.................................................sp............cho.lttApth.G.ts.sa.p..............lasGl-lptsG..............hpsph..c.h...sshLcp...............t.phch....SluLF...AP...s.....hhhp.........s..................htpsatc.pEchaasGhpssPptp..................ssspsWh.Ghus.hlss+oshsu................................................sF.hTsFNsGpGhcaa..........................................................	0	71	108	148
+435	PF04101	Glyco_tran_28_C		Glycosyltransferase family 28 C-terminal domain	Bateman A	anon	Pfam-B_1105 (release 6.4)	Domain	The glycosyltransferase family 28 includes  monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). Structural analysis suggests the C-terminal domain contains the UDP-GlcNAc binding site.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.96	0.71	-4.59	34	6284	2012-10-03 16:42:29	2003-04-07 12:59:11	11	38	4635	6	1557	7997	2525	160.10	23	45.21	CHANGED	hlhVhsG.Spstp.lNphlhphtthhtpt...............................hplhhtsGts.shpthptp..htph................hsahcphsphhppA-.llIo+uGAuTlhEhhthGtPsIllPh.ptht.tH.pppthplsp.thushhhhttphs....cpLtptltchhppppp....hppspt........hpphtshhcpl	....................................................................................................................................lLl.h..GG....S...G.Ap...h..lN....p..h.l.....p...s.h..s..t.l.t.pp...........................................................................h.p.ll.a.sG..cs...php.p.h.p.pt.....htpht.....................................thph..h.s.a.....h..c.....c.........h.......s.p.h.h.........s.........t.........A.........D...l..V..lsR.u.GAsTl.sElh..s.......h.....G.....h..P...s.l...l...l...P.h.s..tt....p..t.cQhtNA.t...l.tc...tG.u..u....h..h....l.....t....p.s....p...hs..........sp..tl...h..p.t.l.t.....p...h.p...ptt.......h.th.ttt.....................hh...........................................................................	1	542	1040	1326
+436	PF00852	Glyco_transf_10	Fucosyl_transf; 	Glycosyltransferase family 10 (fucosyltransferase)	Bateman A	anon	Pfam-B_1677 (release 2.1)	Family	This family of Fucosyltransferases are the enzymes transferring fucose from GDP-Fucose to GlcNAc in an alpha1,3 linkage [1]. This family is know as glycosyltransferase family 10 [2].	21.00	21.00	21.10	21.60	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.29	0.70	-5.88	49	1458	2010-01-08 14:05:26	2003-04-07 12:59:11	14	27	340	9	858	1374	288	287.80	23	74.46	CHANGED	pphhhshhhhshhhshhhhhhhh.htsssssh.t..t.............................ppphhl.LlWhaPFstphs.............hssCtphh.shss..ChlTssRshhscA...cAVlhHH+-lp.t...hssLPpt....................................RP..tQcWlWashESPops.....phsslps.lFNhThoYRpDSDIhhPYGhLhstpsttp....................hslP....pKs.......+..lVsWlVSN...astppt...RspYYpcLpcH.lpVDlaG+s............sp.lstsp...hhpslupYKFYLuFENS.lHpDYITEKLa.NsLtsGsVPVVLGPsRtNYEpF..lPs.-uFIHV-DFsosccLApYLhtLDcN-ptYhcYFpWRcphpl.....phht..htp...................hh....CpsCptlppt....pphps..hpsl.tsWah	...............................................................................................................................................................................hh....................................................................................................................................................................C..h.......p..pt..........t.......psllh...................h................h.s..............................................+....p...a.hh.ht..E..s...P......t..................h.......h....t..ha..N....h..Th.o.a......+.h.c....S....Dl.....h..s...h...t..h..h.....h...t....................................................................p.Ks..................t...hss.ah.sSs..................sp.......s.t..pt...............R.....p......a..h....p....p...L....t....ph.....l.....p......lDs.a...Gps...................................................................tt.h...s..t..tp..............hhp.h.l.s.pYKFhL....uF.EN.o.h......s...pD.YlTEKh.a...s....ul...hss.....s.....VPlhhG....p.....ssh..p..p..h.........hP..s...pS..a..I..plp..D.F.p.ssppLApalphLs..pspphY...p.Y.h...t.....W.+...tp.h....................................................................C.hC.hh.t...............................................................................................	0	422	516	726
+437	PF00982	Glyco_transf_20	TrehaloseP_syn;	Glycosyltransferase family 20	Finn RD, Bateman A	anon	Pfam-B_1035 (release 3.0)	Family	Members of this family belong to glycosyl transferase family 20 [1]. OtsA (Trehalose-6-phosphate synthase) is homologous to regions in the subunits of yeast trehalose-6-phosphate synthase/phosphate complex, [2].	19.40	19.40	19.40	19.40	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	474	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.53	0.70	-6.02	23	2717	2012-10-03 16:42:29	2003-04-07 12:59:11	16	20	1706	12	1143	2357	379	432.00	33	74.10	CHANGED	s+hllVSN+lPls...hpRps...suc..aphshSuuG..Llsshpulppp......tph..hWhGhsGlpssppc.....pspls.......ppLppcas..........shPlaLs......-chhcpaYpG......aupslLWPlFHYhhs.......ptpa-cstWpuYhcsN+hFA-plsphhp...csDhlWlHDYHLMLLPphLRcchsc......hKIGFFLHsPFPSSEIaRsLP..sRpEILcGlLusDLlGFHTh-YARHFLSsCsRlLs..................lcspss....tlcatGRplsVtuhPIGIDssphtcslppssVtp+lppL+pca.pthKlIlGVDRLDhlKGlspKLhAa.EpFLppaPEapGKVVLlQlusPoRscsc-.hpplcpplp-lVsRINucaGsls..apPlhalcc.slsap-hlALashuDlslVoulRDGMNLVuaEYlssppc...............+cGsLlLSEFsGuApsLs.GullVNPWshcclAcAlppALsMoc-c+pt+ac+ha+hlspassshWucsFlp-Lpc	.......................................................................................................................................p............................................ht...u...sG..G...Lss.u.l.shh.pt............tts.....hWhG.....W.s.........G..ss.tsp............tlt.....................t.s..p..h.s.............................................................................hhsl..L.s.............ppph...cpaYps..............................Fu..N..ssLWPlaH........Yh.................................hspa...p...c.p...tW.puYhcVNphFAcpl....hthhp.............cs..D.........h.....l.WlHDYH..Lhhlsp.hL.Rc.t..t.sp................................s+IGFFLHl..PF..PssElapt..L..P...................h+..ccl.Lc.....ullshD..............LlGFpT.s.t....ppF.lsss....p.phh.t............................................................hp.spss.........thph.....G....+....th......p....lts...aPI...GI....-s..pp..h.t.p.hs.........p...t.....s.....t.........l....tt..c......h....t.....pl..+..p...p.....h..........t......s.................h......p.l.l..luVDRLDYoKGlsp+lhAaEthL.....cp.hP..pa.p.............s..+..l.shlQ......lA..s.s....S.....R.......t...c.....l.p.........t.....Y............p....p....l+pplpphsGRING.c.a.........G...pls.........a........s.P..l.h.a........l.p....p...ph.s....h.pp...Lhulaph........uDlsLVTslRDGMNLVA+EYlAsp...ss.............................................................................psGsLlLScFAG.A.A.p.p..L...s...t..u............l............l.V.NP.............a.......Dhcth....As....Al...p...p...A...L...s....M...s.....t...E+.....tp.....Rhpphhc.hlhppsl.shWtpsFlpcLt.t.................................................................................	0	336	691	979
+438	PF01755	Glyco_transf_25	LPS_glycoyl_T; 	Glycosyltransferase family 25 (LPS biosynthesis protein)	Bashton M, Bateman A	anon	Pfam-B_1857 (release 4.1)	Family	Members of this family belong to Glycosyltransferase family 25 [1] This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyse the transfer of various sugars onto the growing LPS chain during its biosynthesis.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.38	0.71	-4.67	22	1865	2012-10-03 05:28:31	2003-04-07 12:59:11	12	20	892	0	399	1567	1071	173.10	22	55.71	CHANGED	h.thalISLcpu.cR+phhppphtp..........plsFpFFDAlsscphpp...........................p..tt.h..hhpphhhtp.LohGElGChhSHhhLWpcslcps....hphhhIhEDDlhlspph...ht..........t.tal.h.thh...a....h.h.ph.sah..shphcpp.h..............................................h..h.pthhGTsGYllo.puAcchlphh.pphh....hslD.hh	............................................................................................................h...halIs.L.tpt...p.Rhtth..ttp.htp............th.t.h...p...hh-Alsspthst......................................................t.t...h..h.......h..h.h.p........h........t.........l.o.....G.E.........lGCahSHhtlWcphl.....c...p...s..................phh..ll.hE.DDl..h..h.p.p..s.....h.....t...h.t..h..t...................t..th...lh.................................................hh.h.......................................................................................................................................................................................h.............htshuYhlo.puAphhlph.......h......hshD.........................................................................................................................................................	0	99	205	301
+439	PF00777	Glyco_transf_29	Sialyltransf; 	Glycosyltransferase family 29 (sialyltransferase)	Bateman A	anon	Pfam-B_1020 (release 2.1)	Family	Members of this family belong to glycosyltransferase family 29 [1].	20.90	20.90	21.10	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.87	0.70	-5.25	105	2130	2010-01-08 14:04:21	2003-04-07 12:59:11	13	26	197	3	993	1851	142	224.50	21	69.43	CHANGED	ss.tph..hhtppssthsp.....phhhs.hs.ppps..plspsltplhs.......t.Pht.pp...........h+pCAVVGNuGlLpsSphGpcIDsaDhVlRhNhAPlps.accDVGsKTohphhsPpsh.pp..............hspsshhhhls..hhstshhWlsuhhhpp.......sshhthhh.hhhphhhspppl.........................................hlhpP........pal+tltphahppsh........csphPS..........TGhlhlhhAlphC-c.VplYGFhs.....tsp.sh.pHYY..-phh.phht.......HshshEhthlpcL.tppG..hlchhhsp	................................................................................................................................................h...h..........................t.......................hppCA....VVGNuGhLhsSphGp.c.............I.Dp..tDhVh........R....h..NtAP.sp.s....ap.pDV.Gs+Ts..hhh......hsspsh....t.......................................ttp..h.h..h....h........hs..thh.ah.shh.pt...............................t....h..hh....h.......h...h.........h...t....p.h................................................h..h.h.p.P................thh.t...h...t.t.....hhhp..h.........................phph.o..........oGhh..h.hhhAh...ph.C-p....lplaGFhs...........pt.t...h..HYa.....-.p............t..h...................Hph.hEh.hh..ph.p.....th.......t..........................................................................................	0	297	410	626
+440	PF03360	Glyco_transf_43	Glyco_tranf_43;	Glycosyltransferase family 43	Mifsud W	anon	Pfam-B_1447 (release 6.6)	Family	\N	20.20	20.20	20.80	20.60	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.28	0.70	-4.77	15	602	2012-10-03 05:28:31	2003-04-07 12:59:11	11	9	129	16	335	571	6	196.50	36	58.65	CHANGED	LupTLppVs.sLHWIVVEDussssP.hVuslLcRoGLs..aTalst+TPpsac....t.p.hhsRGshQRNhALcalR.............ppppcGVVYFADDDNoYsLcLFp-.hRslc..+lGlWPVGLlG...........................GhhVEuPhlpss..KVluap....ssWcsc..RsFslD...........MAGFAlNlcllLp.....+ssAsFshcs.p...GhpEoshLcpLsh.chs-lEPh.ussCo...cILVWHTRTcp	...................................LupTLhhVs...sLhWlVVEDutpps......sspl...Lpp..oG.......l....asHLss.....p.s....tthp............p.h.h.sRusp..Q.R..NhALp.alR............................ppphpGV.....VaFAD..D.DNo.........YslcL.F-E......h................Rp...sc....plusWPVu.....h.lu................................shhhEuP.h.s...psu.....+Vl..Gap......................ssap.sp...R..s..FslD............................................MA.GFAlshp.llhp................................pspsh.hphps.p.....GhpE.o..sh..L..pp.ls....s.pc...l.Esh....u..ssCo.........clLVWHs+oc...........................	0	90	147	256
+441	PF01501	Glyco_transf_8		Glycosyl transferase family 8	Bateman A	anon	Pfam-B_730 (release 4.0) & Pfam-B_5903 (Release 7.5)	Family	This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase Swiss:P27128, lipopolysaccharide glucosyltransferase 1 Swiss:P27129, and glycogenin glucosyltransferase Swiss:P46976.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.73	0.70	-5.05	67	5748	2012-10-03 05:28:31	2003-04-07 12:59:11	15	52	1943	49	1770	4515	1043	233.00	18	55.72	CHANGED	slshshspsY..................................lhushsslpSllpssst...............................hthphhhhssslsscthpplpthhpth..h.......................................httphhshhsasRhhlsc.........................lh..sphcKllaLDuDllV.hpslspLaslshs.s.hhusstp...............................p....tth...t...sshFNsGhhlhshstWpppslppphhph..hphptp......h.hs-QshlshhFt................sphp.LshtaNhhshhh..................t..hp.h.ppstllHa....sG...ttKPWpphs	...................................................................................................................................................................................l.hshsts..a.......................................h.tshsh...htSlh..hp..sp....................................................hththh.l...h...s.s...t....l..s........t...p.........h....p..h...l...p....p....h..h...p...p....h....t....t....h..........h..h......s....................................................................................................ttph..h..s..h.h..s..a..h.R.h.h.l....p................................hh...sp....h.....c....+.llYLDu.D.lls....h........s..........s....l.s..c.L.......a....s....h...sht....sth...h.us....s.s.....................................................................................t...................h....t............ht..................ss.h.....F..NuG.l....hll.shp.t..h...p.....p......p....s...l...p.p....p.h...hph............hptptt....................h.hh.D.......Qs....h..L..N...h...h...ht......................................sp.h...h.....L...s.h.p..a....Nh.hthh.................................................t.......t.....h.....p..p..s...hl..lH.a........hu.........KPW.................................................................................................................................................	0	480	946	1364
+442	PF00535	Glycos_transf_2	glycosyl_transf_2;	Glycosyl transferase family 2	Bateman A	anon	MRC-LMB Genome group	Family	Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.86	0.71	-4.57	253	43678	2012-10-03 05:28:31	2003-04-07 12:59:11	21	600	5370	41	12098	45842	18220	163.70	16	45.40	CHANGED	SlllPsaNc.......tphltpslpolhpp..........................h.phEllllDDuS.sDso..hplhcphht...........plpllppsps...Ghusuhstulpt.upGc....hlhhlDuDshhtss.hlppllphhpp.ssthshsshhthttpttththh..................................hhhttttttthththhhhhsstthhppphhtphh	......................................................................................olllPs.a..Np........tph...l....t...p...s....l...p...o...l...hpp......................................................h.shE.....l....l..l.....l.....D....D......u.........S....s.......D........s....o...........hp.....l...h.pphtt..................................p.l..p...h....l.....p........p.......p.........t.......s...........h......G.......h..........u......s.......u.......h......s......t....G....l.........p......t......A.......p...uc.....................hl.h.h.l.D...u.D......s..h.......h......s.........s....s....h....l.....p....p........h....l...p....h....h......p........p.................s........h.....t.....h.....s..h...s....s....h..h.h.h...t..t.........................................................................................................................................................hh...........................................................................................................................................................................	0	4072	7912	10203
+443	PF00953	Glycos_transf_4		Glycosyl transferase family 4	Finn RD, Bateman A	anon	Pfam-B_534 (release 3.0)	Family	\N	21.40	21.40	21.40	21.70	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.31	0.71	-4.43	116	8422	2009-01-15 18:05:59	2003-04-07 12:59:11	16	18	4730	0	2028	5693	4534	172.80	31	48.36	CHANGED	hhhhh....hssh...llshlGhlDD...h.........h......slsshh+lhhphlsuhlhhh..................................shttlshhhs.................................................h.hs.hh.h.....hh....slhhlsuhh.....NAhNhhDGlDGLu.......uuhulls.hlshshls..........................ssh.hhhh.............slhu.ul.lG....FLhaN.h.P.....A...+lFhGDsGShhlGhh..lu....hlulhht	................................................................................................h..hlLhshhshshlGhlDDh............................................h.u.Lss+..hK.hhh....Qhlsullhh.hhhh............................................thstls.h.hh...........................................................................................h.h.sl.u.......h.h...hl......hl....slhhl....luhs....NAl.NL.sD........GLDGLAuusssls.hsuhullu..............................................................hht.............sphpl.sl.h...............sh..............ullG....Ah..LG....FLhaN...hhP............A....clFMGDsGSLhLGhh.luslulhh.p..................................................................	1	688	1325	1728
+444	PF00903	Glyoxalase		Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	Bateman A	anon	Pfam-B_1207 (release 3.0) & Pfam-B_5495 (Release 8.0)	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.44	0.71	-4.16	82	14717	2012-10-02 15:00:03	2003-04-07 12:59:11	20	46	3790	237	3666	25008	5991	128.70	16	62.42	CHANGED	tlsHhs........lhlsDhpcuhpFYpcs...LGhplhpphs.............................hhhhhhsssttlplhhttsssstttth.....................................................................................................................................ththhshsscDlttthcclpppG..................sphhtt.scthhsthhhh.......................hpDP.sGhhlEl	...............................................................................................................................................................ltHhs..............lhs..s..-...h..p...c..s...h..p...FY...p...cl......L....G...h.....c...l......h.cp.hs....................................................................h.h.h....h..h..h....t......s...s.....s.....s.....t......l.....p....l....s.......h.....t...........s....s...s..t.t.t.t.t...................................................................................................................................................................................t..h.u....a..h..s.........s....h...c...-.....l...t.......t...h.....h......p....p....l....p.....p...t..G..................................h..p...h....p...t........h.............s.....p....h....h....h...t....t....h...h..........................................hpDP...sG.hhEh..........................................................................................................................................................................................................................................................................................................	0	972	2122	3010
+445	PF04464	Glyphos_transf	glyphos_transf; 	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 	Waterfield DI, Finn RD	anon	COG1887	Family	Wall-associated teichoic acids are a heterogeneous class of phosphate-rich polymers that are covalently linked to the cell wall peptidoglycan of gram-positive bacteria. They consist of a main chain of phosphodiester-linked polyols and/or sugar moieties attached to peptidoglycan via a linkage unit. CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase is responsible for the polymerisation of the main chain of the teichoic acid by sequential transfer of glycerol-phosphate  units from CDP-glycerol to the linkage unit lipid [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	369	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.14	0.70	-5.70	22	3039	2012-10-03 16:42:29	2003-04-07 12:59:11	9	50	1148	20	433	2103	385	317.90	20	61.59	CHANGED	hhhhhthhhP..hcsshllFtuhttcshusNsptlac.hhp..c.tsshchlWshcp...........tth.tssphlthsShchhhhhhcuchllss........s.hss..hhh++psphalQsWHGs.sLKphGh-..t.....h.p.....phht....psppaD...ahlossphpsphap....csFs..hstt.phlphGhPRsDsLhpspttp..httlppphslshscp..llLYAPTaRcsttt.......................hthtlDhcplh....pthtpchhllh+hH.hhsstht.........hppsshllslsstp......clp-LhhsuDlLITDYSSlhFDaulLc+PllhYs.Dh-pY...ppp.RGhYh-.a.ptsPGslscs.p-Llchlpph.ppspt.tcphphhpccasp.apDG+uScRlhphlht	...........................................................................................................................................h..h..............tp.lh..h..s.......t....t..hsss.t.hlhp...hh.......p...t..p..h...p..h..hh.hhp.........................t..th.....t..hl.....................p......h.....c....h.......h.....hh.....tp....A.c.h.hh.s....................s.h.........h..h....h..p..........p......p....h....h...lQ.........hWHus.sh.K.p.h.shs..t...............................h.h...thpph.s..........hhl.s.....s...s.p..h..t...p...h.at.........puat.......hpp...t....p....l..l...h.G......h.PR...Dhlh.....pp....p.tp.............tth...p....p..p.....h......s......l..........t..tcp..........ll.LYA..P.T..a..Rssttt..................................h.h...s..h.....p.tlt........tht.p.....sh....h..l..l.h+hH.......h...h...t..p..p.h.........................thtp.h..h..h.s.h.s.s..h..............................ch.p-..l..hhh..sDl..l.ITDY.SS.lha.-..a.h..h..h..c..+..P...h.l...a...a....s.............Dh....p...p....Y...............pp....R.s.h..h..s...h....p...........h..s.............u.....h........s..p.......s......pt.Lh.p.t....l..p..p......................................t....h............h.....hp.....t..h....hpst...p.s.spphhp....t........................................................................................................................	0	162	296	399
+446	PF00958	GMP_synt_C		GMP synthase C terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1137 (release 3.0)	Domain	GMP synthetase is a glutamine amidotransferase from the de novo purine biosynthetic pathway. This family is the C-terminal domain specific to the GMP synthases Swiss:P49915 EC:6.3.5.2. In prokaryotes this domain mediates dimerisation. Eukaryotic GMP synthases are monomers. This domain in eukaryotes includes several large insertions that may form globular domains.	21.10	21.10	21.10	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.23	0.72	-4.27	161	4898	2009-09-11 08:43:03	2003-04-07 12:59:11	17	31	4651	24	1280	3535	2105	95.50	57	18.75	CHANGED	h-Elccs.......GLYcclWQuFAV.Llsl+SVGVhGDpRoYsas...................................................................................................................luLRAVpSpDuMTA-as.....c.lP.........a-hLpclSsRIlNEVpuVNRVVYDITSKPPuTIEW	...........................................h.EElppAGL.cclaQsFsV.l.h.s.V+S..VGVMGDsRT.Y-..a.s...........................................................................................................................luLRAVsohDhMTAcaA.........+l.P..........................a-lLt+lSsRIlNEVc.slNRVVYDIoSK..........PPATIEW...................	0	423	820	1086
+447	PF01825	GPS		Latrophilin/CL-1-like GPS domain	Bateman A	anon	SMART	Family	Domain present in latrophilin/CL-1, sea urchin REJ and polycystin.	21.50	21.50	21.50	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.64	0.72	-3.85	139	2565	2009-01-15 18:05:59	2003-04-07 12:59:11	16	386	110	4	1472	2317	28	46.70	35	3.56	CHANGED	tpstCsaWs..........pspusWu.ocG..Cps.hp.sst............................sp...s.pCpCsH...LT.sFulLh	.............................h.pstCsaWs......................sttGtWo..opG..Cph..hp...ssp..................................sp.......o.pCpC...sH....L.T...sFAlLM............................	0	524	628	925
+448	PF02893	GRAM		GRAM domain	SMART	anon	Alignment kindly provided by SMART	Family	The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.24	0.72	-4.45	33	2555	2012-10-04 00:02:24	2003-04-07 12:59:11	15	89	326	5	1481	2393	6	70.70	24	10.41	CHANGED	pch+.phFp......lstsEpllss......asCtlhp................ph.hpGplYlospclsFpS.hhss.t...........shslPhsslpplcKhs	...........................................................................................ap.phFt......lst.sEpLhps...........................as.CsL.p.................................ph..h..pGplal.ospp...l.sF.t..S..h.h..sp.s..............................plslPhtplpplcK..t...............................	0	338	634	1024
+449	PF03514	GRAS		GRAS domain family	Bateman A	anon	Pfam-B_393 (release 7.0)	Family	Proteins in the GRAS (GAI, RGA, SCR) family are known as  major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development [1].  Mutation of the SCARECROW (SCR) gene results in a radial  pattern defect, loss of a ground tissue layer, in the root.  The PAT1 protein is involved in phytochrome A signal  transduction [2]. A sequence, structure and evolutionary  analysis showed that the GRAS family emerged in bacteria  and belongs to the Rossmann-fold, AdoMET (SAM)-dependent  methyltransferase superfamily [3]. All bacterial, and a subset  of plant GRAS proteins, are predicted to be active and function  as small-molecule methylases. Several plant GRAS proteins  lack one or more AdoMet (SAM)-binding residues while  preserving their substrate-binding residues. Although GRAS   proteins are implicated to function as transcriptional factors,  the above analysis suggests that they instead might either   modify or bind small molecules [3].	19.90	19.90	20.10	20.50	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.25	0.70	-5.74	31	1831	2012-10-10 17:06:42	2003-04-07 12:59:11	9	14	343	0	790	1894	0	305.00	31	67.57	CHANGED	LhphLlpCAcAlss..sshp..hAptlLtclsph..uSstG.s.....shpRlAsYFsEALssRlss.....h.p.h.ssptss......sschhtuh..................ph...a.cssPhh+FuahTANpAILEAhcsp...ppl..HIIDFsIspGhQWPuLhpuLA.pRs....su......sP.plRlTGlus.t........stttLppsGpRLspFAcplslsFcFps....hsp.phspl...phptL....plps...sEslAVNhshtlH+hh.......................................................spssshtp.....thLphl+slsPclVTllEpE..ssp.Nss......sFhsRFhEuLcaYoulFDSL.css............hs.ts..ppRthlEchhlu+cIhsllAsEGsc.RhcRpEshtpWRp+htp.uGFpslsluspshpQAchLLphas.scG..aplc...-c......susLh.LuWps+sLlssSAW+	................................................hphLhtCApAltt....ts.hp......hApt.lltp..l.t.h......us.stu...s.................s.hp...+.lAtaF.scuLtt.Rlht..............................h.....stt.........................ph.h.h.....................................h........hhphs...Pah+huahsANpAIl-Ah.t.sp...................ppl.....Hl.lDa.s.........h....t......G...h....QWssLhptLu..........Rs.......sG......................PP..thRlT.uls.s...................stttlppsG.+LsphAc....p..h.t..l...F..c.aps.......................hst....ph..t..s.l.............p.....p....L.........plp..............sE.sls...VN..h.hth....+plh.......................................................................................................................sp....ss.s.htp.............hL..........phl+.th........pPc..........lhs..lsE...p-.......ush....s...s.s...................FhsRFh-u...Lp.aYushFDuL.c..ss.........................h.s...ts........tpc.hhhpp.hhuppIhsllu..s..........-..G.p.....Rh...........E.....R....Et...........h.t..........pWptph..tt..uGF.t...h.ls........sht.p.s..p..hl.t..........h....................t..........a....h.......tt............t.t...hh...tW.t...hh..osW........................................................................................................	0	78	520	682
+450	PF01465	GRIP		GRIP domain	Bateman A	anon	Sean Munro	Family	The GRIP (golgin-97, RanBP2alpha,Imh1p and p230/golgin-245) domain is found in many large coiled-coil proteins. It has been shown to be sufficient for targeting to the Golgi. The GRIP domain contains a completely conserved tyrosine residue. At least some of these domains have been shown to bind to GTPase Arl1, see structures in [4,5].	20.50	20.50	20.50	20.80	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.90	0.72	-4.44	44	627	2009-01-15 18:05:59	2003-04-07 12:59:11	15	21	256	8	415	639	5	44.60	31	4.30	CHANGED	pshshpYLKNVllpFLppp-..t.+ppll..sVlsolLcFopp-pppl.	............tsshEYLKNVllpFlpt+..-.....tpp..p..Ll..sllsslLpFoscEpptl........	1	146	206	324
+451	PF02946	GTF2I		GTF2I-like repeat	Bateman A	anon	Pfam-B_101 (release 6.4)	Family	This region of sequence similarity is found up to six times in a variety of proteins including GTF2I.  It has been suggested that this may be a DNA binding domain [1,2].	20.60	20.60	20.60	21.00	18.90	17.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.42	0.72	-4.14	18	742	2009-09-10 22:54:23	2003-04-07 12:59:11	9	8	42	10	300	939	0	75.00	47	38.66	CHANGED	LRcpVc-LFspKYucALGhspsV.VPYpphhppPpslhVpGLP-GlsFR+PssYslspLc+ILcspcpIpFslK+P	............LRcpVc-LFspKa...u..EALGh..spsVtVPYp+hppsPpslhVpGLP-GlsFRcPssaslspLc+ILcspppI+FlIKRP......	0	17	38	98
+452	PF01018	GTP1_OBG		GTP1/OBG	Bateman A, Studholme DJ	anon	Pfam-B_875 (release 3.0)	Domain	The N-terminal domain of Swiss:P20964 has the OBG fold, which is formed by three glycine-rich regions inserted into a small 8-stranded beta-sandwich these regions form six left-handed collagen-like helices packed and H-bonded together.	21.50	21.50	21.50	21.70	20.70	21.30	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.19	0.71	-4.58	8	5081	2009-01-15 18:05:59	2003-04-07 12:59:11	17	23	4657	3	1432	3621	2408	149.90	46	37.77	CHANGED	FVDpscIhlpuGsGGsGhVSFRREKalPtGGPDGGsGG+GGDVlhEsDpslsTLlDaRap+HaKApsGppGtucNpsG+sGcDlllKVPsGThVhD.-ssplluDLVcsGpRhllApGG+GGLGNu+FtSssp+APpaApsGpcG-pRplpLELKl	.................................................FlDpspIhlpAGcGGsG.sl.............u...F....R......R..E...K...al..P...h.....G....G........P..s.GG....DGGcGGsVhh........s..Dc..s..l..p...TL...lD......a..R......a...p...+.+....a....+A..pp.Gps....G...t.....u......p..s......p.p..G.+..........s.......G....c..D..lhl+VPsGT....h.......V........h...............D........t.............c..................T........s........c........l.................l........uD...Ls..c..p...G.p.c.hl.lA+GGpGG....h.G..Nt.+.F.....t.....o....s..s.........NpA...P.....ch.u.....p................GpsG.-c+plhLELKl..................................................	0	493	898	1211
+453	PF00009	GTP_EFTU		Elongation factor Tu GTP binding domain	Bateman A	anon	Prosite	Domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.24	0.71	-4.86	216	69868	2012-10-05 12:31:07	2003-04-07 12:59:11	22	241	24054	243	11959	72575	19001	186.10	31	41.29	CHANGED	cphhNlullGHVDcGKTTLssplhhhsuh....t..t...t..t..............hDphppE+cRG.....ITIpsutsphp.....................................spptphsllDsPGHtD.FspphhpG..hu.hDuAlLVlsAs........cG.......stsQTccthhhApphsls......hll..hlNKhDps...........p.tchtclhcpltpph...........................................................................................lpth..hss...........................thsl.l.sSAhpuh..................slp......................................................................................................s.Ll-slsphlPs	..........................................................................................................................................................................p..st.....GKooh...h........t...t..l..h.............................................................................................................hD......h..t......E....c...p...R..G.......I..T...I...p..h..u..h..h.php.....................................................................................................htphhls.l...l..D.s...........P..........G............H.............t............D..........F............h...........t...........p...........h...........h...........p....u................hs.........s......D........s.........A..........l........L...l.....V...s..A.s..............................s.G.........................hp..s..Q......T.....+......c........t......h.........h........h.........A.........h........p.........h........G..............l................ll..V..s.l...NK.....h.Dps..........................ps.c..h..p....c..l....h...c...p...l.p......ph.......................................................................................................................................................................................................................lp.th...shsst...................................tss.h.l...h.S.....u......hp.u.....................................s.h.......................................................................................................................................p.Ll-sl.t.................................................................................................................................................................................................................................................................................	1	4102	7392	10000
+454	PF03144	GTP_EFTU_D2		Elongation factor Tu domain 2	Bateman A	anon	Prosite	Domain	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.28	0.72	-3.86	305	58968	2012-10-05 12:31:07	2003-04-07 12:59:11	20	172	19933	232	11011	44749	11474	68.00	28	14.18	CHANGED	GslssuRl.sGpl+hGsplhlh..t....t..............sclpsl.hhpt.thpps.....................hsusssGhhltshshcc...lptGpsls	...............GslsssRVpsGsl.+.s.G.ph.V..h..hh...s.s.....................................scV...p..ul..p.h...a...+.p....t...h.p.c.s.................................................ls.G.s..s..s..G....h.....l..p.s..h.s..hc-......lppGpsh...........................................................	1	3673	6761	9154
+455	PF03143	GTP_EFTU_D3		Elongation factor Tu C-terminal domain	Bateman A	anon	PF00009	Domain	Elongation factor Tu consists of three structural domains, this is the third domain. This domain adopts a beta barrel structure. This the third domain is involved in binding to both charged tRNA [1] and binding to EF-Ts Pfam:PF00889 [2].	21.30	7.10	21.30	8.40	21.20	-999999.99	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.29	0.72	-3.83	82	23082	2009-01-15 18:05:59	2003-04-07 12:59:11	12	49	16442	102	2870	18678	2585	86.00	47	25.05	CHANGED	slpsppcFcApVhlLs+.....poshhsGYpP.hah+Tsclss.hhpL.........stts......chlhsGDsshlplchhp.PlslEptt......RFAlR-GG+TVusGllpclh	..................................s+ssscFsAQ...VI.V...LNH............PGp.I.ss.G........Y...sP.V.Lc.s.H.Tu.clss.........+h..sEl....pt.h-.............sucs........................c.ltsGD..ss.h...l.p....l...........+...P.h....s...l.Eth..........................cF....................................................................................	1	948	1617	2282
+456	PF01493	GXGXG	DUF14; 	GXGXG motif	Bashton M, Bateman A	anon	Pfam-B_428 (release 4.0)	Family	This domain is found in glutamate synthase, tungsten formylmethanofuran dehydrogenase subunit c (FwdC) and molybdenum formylmethanofuran dehydrogenase subunit c (FmdC). A repeated G-XX-G-XXX-G motif is seen in the alignment.	19.80	19.80	20.60	20.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.42	0.71	-5.32	29	4251	2009-09-11 14:28:49	2003-04-07 12:59:11	14	50	3290	15	1375	3769	3934	186.10	39	14.86	CHANGED	hphslhsscRslssclsstls+thGpps.h...............sslplphpGoAGpShGuahssGhp.............lplpG-AsD..alGpuhsGGcIllpsssss...........shtsspsshhGssshaGATGGplahpGpAG-Rhul+N...........SuuphVlEGs.GsassEYMsGGhllVLGcsG..........cNhGAGMoGGhsYlhsc.s..............shspphshchVchp...plps...........tstppL+tl	.............................................................h....ltNssRsl.Gshlustl...sc..p.aGppG..L..........................s.t.s.slplph..p..G.o..A..G.Q..S.F.G...u..a.h..s..t...G.l.p.........................................lplpGDA.ND..YVG.K.G.h.uGG..pll.l.p..Pshss.............th.s.pcshIhGNs.sh.......YG........A..TuG.c.la.hp.Gp.A..G..E..RFuVRN...........................SGApsVVEG................s.G..D......a..uCE.YM........T........GGhVllLGp..sG....................pNFu...AGMoG.GhAYVh-pss..............ph.t.t..p.s.N...chlph............lpt..................h.....................................................	1	407	886	1167
+457	PF02756	GYR		GYR motif	Ponting CP	anon	Ponting CP	Motif	The GYR motif is found in several drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues may suggest it could be a substrate for tyrosine kinases.	20.60	20.60	20.70	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.19	0.73	-6.39	0.73	-4.01	4	377	2009-01-15 18:05:59	2003-04-07 12:59:11	9	37	13	0	227	370	0	17.80	73	19.15	CHANGED	-DGY+YKTVRRL+hRhRH	...DGYcYKTVRRLKaRpR+..	0	34	34	134
+458	PF03457	HA		Helicase associated domain	Yeats C	anon	Yeats C	Domain	This short domain is found in multiple copies in bacterial helicase proteins. The domain is predicted to contain 3 alpha helices.  The function of this domain may be to bind nucleic acid.	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.41	0.72	-3.87	186	906	2009-09-13 12:23:34	2003-04-07 12:59:11	9	52	116	1	382	984	370	69.10	24	38.11	CHANGED	hss...hpppWppta.ptLppatppcG...p..tp.lPpsh....................shpLGpWlppQR....pth+p..................sp......Lst...-+hptLspl..shh	.............................pttWpp.ta.ptLppatppcG.................p...hp..lPp.sh..t.....................shtLGpWlspQR.............pphcp....................................................up............Lss......-RhptLcplGh....................	0	258	341	371
+459	PF04408	HA2		Helicase associated domain (HA2)	Bateman A	anon	Bateman A	Domain	This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.	21.30	21.30	21.30	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.36	0.72	-4.00	140	7005	2009-01-15 18:05:59	2003-04-07 12:59:11	18	172	2406	5	3299	6442	376	102.00	28	9.96	CHANGED	pulphLhtLGAL..........st....ps.................pLT.tlG+phuphP.l-PpluKhL..l.husphsC.........hcchlsIsuhLos.pssFhp..............................s.t.tttsp.........................................................t..t+tph.............ps.........DalshL	...............................................................................t.AhphLppL.GAL.........................ss......ps.......................................................pLT..slG...+ph...Apl...P....l.....-P+L..u.+.Ml.......l..t.u...t....p..h......s..C.................................hpp..sls...IsAhL..oh....ps..sh.p.................................................................................................s.t.t.pt.tsp............................................................................t..h+.th....................................uDhh...............................................................................................................................................	0	1063	1774	2655
+460	PF04774	HABP4_PAI-RBP1		Hyaluronan / mRNA binding family	Kerrison ND	anon	Pfam-B_2044 (release 7.6)	Family	This family includes the HABP4 family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1.  HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo.  It has also been observed to bind RNA, but with a lower affinity than that for hyaluronan [1]. PAI-1 mRNA-binding protein specifically binds the mRNA of type-1 plasminogen activator inhibitor (PAI-1), and is thought to be involved in regulation of mRNA stability [2]. However, in both cases, the sequence motifs predicted to be important for ligand binding are not conserved throughout the family, so it is not known whether members of this family share a common function.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.94	0.72	-3.54	39	511	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	219	0	289	525	1	99.40	26	29.83	CHANGED	s+RpFDR+SGosRu..............s-..KRpGuGptNWGosp--.h................sph.-.s.ss.t-ps.ssEp.s.....t-cs........scEssscptt...Epc..sKEMTL-Ea.KsLp-Kp+uh.s...hph.cctcss	.......................................................pRta-Rp.S..G.os+s................tp.K+tG......uGttNW.GsspD-..l..........................sc.h.....-ps....s..tp.cs..s.....t....tEpts..........tppt............sppptspt.t.....Ept......spEhTL-Ea.Khhpp.pp+s.h.t...hphcc.t.............................................................	0	102	154	221
+461	PF02183	HALZ		Homeobox associated leucine zipper	SMART	anon	Alignment kindly provided by SMART & Pfam-B_1492 (Release 7.5)	Family	\N	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.13	0.72	-4.24	69	597	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	81	0	280	618	0	43.70	38	16.66	CHANGED	KQLE+Da-hLKpsa-sLppc.-sLppEppc.L+uplhsLppphttp	....KQhEhDh-hLKcsa.-sLpp-sc.......pLp+E.......hpc.L+A.hht.p.h....t..........	0	43	169	230
+462	PF00672	HAMP	DUF5;	HAMP domain	Bateman A	anon	Pfam-B_113 (release 2.1)	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.25	0.72	-3.79	222	60876	2009-09-13 11:30:41	2003-04-07 12:59:11	20	935	4667	65	16414	49005	5371	70.40	19	12.75	CHANGED	hh.hhhhhslllshhhshhlspplhpPlppltpssppl.u.p...........G...cl...s.............s.h......ttsElupLupuhNpMtppLpp	...........................................h..hhhhhs.l.l.l.s..h.....h....h..s...h....h....l....s.....p........p.........l.......h....p........P.....l....p....p....l.t....ps....s....p....p.l..u..p..........................G............cl.......s..........................................................ppl.......shp...sp..c..E...l.up...Lu....pu...h....Np.MhppLp.t.......................................................................	0	5121	10085	13473
+463	PF04849	HAP1_N		HAP1 N-terminal conserved region	Mifsud W	anon	Pfam-B_4571 (release 7.6)	Family	This family represents an N-terminal conserved region found in several huntingtin-associated protein 1 (HAP1) homologues. HAP1 binds to huntingtin in a polyglutamine repeat-length-dependent manner. However, its possible role in the pathogenesis of Huntington's disease is unclear [1-3]. This family also includes a similar N-terminal conserved region from hypothetical protein products of ALS2CR3 genes found in the human juvenile amyotrophic lateral sclerosis critical region 2q33-2q34 [4].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.93	0.70	-5.48	8	271	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	86	0	153	239	0	249.20	44	35.16	CHANGED	hppp...............lssaulRADsltsa-.............ps-Wt.osthusstp.slos.phppsL+ah..hLCssRssQMTK.TasDlDulhpLLEE................KERDLELAARIGQSLLKpN+sLp......................EcN-tLEEpL..............................ppsh-plsQLRHELshKDELLQhYos..ssEEuEsESssossh..........................+.pcupstspph.pL-sLQcKLKpLEEENppLRpEAs+L+pETh..ThE-KEQpLlpDCV+pLc-ustQluuLoEELupKoE-hsRQQEEIo+LluQIVDLQ+KsKpaulEsEELpppLsuuK-uQcQLpAE.......LpELp-KYtEChtMLtEsQEElKsLRs+s	.........................................h........................................................................p....tt.h..h....lLsspRVtQMTK.T.YsDI-sVT+LLEE........................KERDLELAARIGQuLLc+NpsL.p..........................................................EpN-hLEEpl........................................................................................tphh-plsQLpHELshK-ELLphhopss.-..-u-s-usssp.h..........................................h..t...s....pthhpL-.LQcKL+pLEE...ENh.LRs.EAspLcp-T...shEEc.EQpL.ltD.C..VcpL...p..-uN.QhsploEELutKs--hhRQQEEIopLluQll-LQp+h+ths..hE....pEELhtpLtus.K-sQ.pp.L..shE................................LpELp-+.tEshthL+EuQEElKpLRp+..........................................................	0	29	43	97
+464	PF02184	HAT		HAT (Half-A-TPR) repeat	SMART	anon	Alignment kindly provided by SMART	Family	The HAT (Half A TPR) repeat is found in several RNA processing proteins [1].	21.00	21.00	21.20	21.00	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.16	0.72	-7.40	0.72	-4.20	3	422	2012-10-11 20:00:58	2003-04-07 12:59:11	11	23	237	0	304	452	7	32.20	46	6.81	CHANGED	KEIDRARuIYERFVaVH.P-VpNWIKaARFEEc	.......Eh-RARsIYE.....R......a....l..h....V.H.Pc.lcsWIKYA+FE......	0	108	161	234
+465	PF02518	HATPase_c		Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	SMART, Griffiths-Jones SR	anon	SMART	Domain	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.30	0.72	-4.35	659	129386	2012-10-11 19:05:54	2003-04-07 12:59:11	21	5116	7141	397	36085	119054	19749	113.50	24	18.95	CHANGED	sstttLtplltsllsNAlchs.tt................splplplptpt.................................................................tphplpV...pD..................s..Gh...Gls..............................p.htplhp.hhphp......................t.tthsG..pGlGLslspp.lsct....hs.Gp.......lphpsp.......................................spGop.hpl.....plsht	................................................................................................................................h...ttlpplltNL...l..s...NA...l....c....astst..............................................spl..p..l...p....h....p...p..p.t............................................................................................................................................................................tp..l..t.l..p......V....p.D...........................s...Gh....G.l..st.....................................................................................................c.t.h..t...p...l....F...c......a.h...pspt.........................................th...s.G.........sG....l....G......L.u.....l....s.....c..p....l.s..c.t.........h...s.....G.p..........l.p.l...p.u.p.........................................................................sp.G.op...hplplP..t...........................................................................................................	0	12473	24121	30935
+466	PF00955	HCO3_cotransp	Anion_Exchanger; 	HCO3- transporter family	Croning MDR, Finn RD, Bateman A	anon	Pfam-B_1004 (release 3.0)	Family	This family contains Band 3 anion exchange proteins that exchange CL-/HCO3- such as Swiss:P48751. This family also includes cotransporters of Na+/HCO3- such as Swiss:O15153.	19.70	19.70	20.00	20.10	17.80	19.20	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.61	0.70	-5.84	18	2233	2012-10-03 01:44:59	2003-04-07 12:59:11	16	22	295	7	1138	1987	18	300.50	27	52.48	CHANGED	sLpRTGRlFGGLIpDlKR+hPaYlSDhpDALssQCLAAllFIYFAsLSPAITFGGLLG-tTcshhGV.E.llSTAlpGllFsLluuQPLlIlG.TGPlLVFEchhFsFCcspsl-YLshRlWIGhWlshlsLllVAhEuShLVRaITRFTpEhFusLISlIFIYEohtKLlclacsaPlptsa.............................................t.hsht.hshtps..hsuhhhsssssh..tstPNsALhSllLhhGTFhlAhhL+cFKNS+FFPuplR+lIuDFuVsIuIllMlhlDahls.shTpKLpVPsshpsTsss.RGWaIsPh...ss.PhWhhhAuslPALLlhILIFM-pQITslIVs+KE+KLpKGuGaHLDLLllulhhulCulhGLPWhsAATVhSloHlNuLpl.ScssAPGEpPchhtV+EQRVTGllVhlLlGLSllhsslL+hIPMsVLFGlFLYMGVoSLsGIQl................a-RlhLlhMPsKapPDhhYlR+VpshRhHLFThI	...........................................................................................................................................................................................................................................................................................................................................t...h...................s................................h...............................h..h...h......h................a..h.hhh.sh.t.....h.h..h.p....tc.hs.h.sh.hh..s........................................................................................................................................................................................................................................hh.....................h...h.ths...................................................................................................................................................................................................................................................................................h.hlhhh-...........t.ls........hh.t...t.........h.......ps..........sh.th..sh.hhhs............h.shhu.hP.......................................t..............................................................................................................................................................................h...............EpRhs.....hh...........h..h.........................h..............l...t..h....P.s..........hh.GhFhhhu.....h.s.....h........................h........h.........................................................................................................................	0	277	517	835
+467	PF01966	HD		HD domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	HD domains are metal dependent phosphohydrolases.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.83	0.71	-4.10	154	24448	2012-10-01 20:28:14	2003-04-07 12:59:11	17	317	4881	70	6755	26042	7473	120.90	18	28.53	CHANGED	hhpHslpVstlsttlutphs..........................p.thhhhuuLLHDlu+sh..p............................Hshhutphlpphtt...................lhphltpHppth........................................................hshtstllphADtlpsh	.................................................................................hpHolp..V..h.p.h.u..t.t...l.u.p.phs.......................................................................s.h...p.l...l...t...h..A...u....L...lHDl.G..+.....s....h....hs.c...................................................................h..t...H.s...h..u...t....p....h...h..p.p.h.t..t..h.............................l...h.....p..hl..t..t.H.p.tth.t....................................................................................................h..........t.h....l.lthsD.ht..h............................................................................................................................................................................	0	2723	4803	5965
+468	PF00271	Helicase_C	helicase_C; 	Helicase conserved C-terminal domain	Sonnhammer ELL	anon	Published_alignment	Family	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	20.90	11.60	20.90	11.60	20.80	11.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.48	0.72	-4.12	480	89228	2012-10-05 12:31:07	2003-04-07 12:59:11	26	1286	6190	172	32236	78491	16395	81.30	23	8.77	CHANGED	phhpttshpshhlaG...................shspppRpphlppFpsspt...................................plLluTslsupGlclsslshVl.h-h....................shs.pp...........hhQphGRsuRhu	................................................................................................................................t......th..t.h.h.h..l..cu..................................................p.h..s..p...p....p......R....p.......p.......h...h....p...p....F....p....p..s.ph...................................................................................................................pl.L..l..u.......T....s...........l....h.....s....p...........G.....l.........c..l.........s.........s..........l.......s........h.........V..l.......h..ch.....................................................................sh.s..hps.....................h.h.Q..p.......h.....G...RsGRs..........................................................	0	11050	19238	26835
+469	PF02602	HEM4		Uroporphyrinogen-III synthase HemD	Bashton M, Bateman A	anon	COG1587	Family	This family consists of uroporphyrinogen-III synthase HemD EC:4.2.1.75 also known as Hydroxymethylbilane hydrolyase (cyclizing) from eukaryotes, bacteria and archaea.  This enzyme catalyses the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O.  Some members of this family are multi-functional proteins possessing other enzyme activities related to porphyrin biosynthesis, such as Swiss:Q59294 with Pfam:PF00590, however the aligned region corresponds with the uroporphyrinogen-III synthase EC:4.2.1.75 activity only. Uroporphyrinogen-III synthase is the fourth enzyme in the heme pathway [2]. Mutant forms of the Uroporphyrinogen-III synthase gene cause congenital erythropoietic porphyria in humans a recessive inborn error of metabolism also known as Gunther disease [1].	27.50	27.50	27.80	27.50	27.20	27.40	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.59	0.70	-5.12	137	4602	2009-01-15 18:05:59	2003-04-07 12:59:11	10	22	3824	15	1293	3545	2287	221.40	21	70.07	CHANGED	sphspt...l..pphG.hpslhhPhlc.hts..........t.ltthh.ptht...phchllhTSssuVch.hhp.h...........................t..hphht....shplh.uVGppTupslcp...h.G......hps.h.....hss.phsu.csL..hp.hltt..........thts.pp...lLh.....hpuphs..pstlh..ptL.p.....ptG..hplpplh...sYcs......t......................httphhphlpp..tph..........cslshsSspsscp.hhphhtt...........hhpshplsu.IGssTucshp.chGhps.....hhu..cpsshcul..lp	...............................................t..h.thl.pt...h.G..hts...hth...Phlc.hps.......................t..t.l.p.ttl.....t.....t.......l.............................phchllhoSts...AVchhhphhp............................................................t...th.ph..t........sh.p.h.h..ul.GpsT.Ap..t.L..cp.........h..G.........hps.th......................hPp....p.tsu..-sL....lp..tltt................................phss...p+....................lLl...................hcustu............pph.ls.......psL.p.....................ptG.....h.p.Vpp.h....sYpp........t...............................htpht.p.t.hpp.....tph......................................ssl.shoSupslps....h.hphhsp.................................hhppspl..hs..lG.psActh....p...p....hG......h..p.s.........h.h..s..pp.s.tulh.t...................................................................................................	0	418	849	1111
+470	PF00173	Cyt-b5	heme_1; 	Cytochrome b5-like Heme/Steroid binding domain	Bateman A	anon	Bateman A	Domain	This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors such as Swiss:O00264 [1,2]. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases.  There is no known ligand for this domain in the chitin synthases.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.61	0.72	-4.18	210	5879	2009-01-15 18:05:59	2003-04-07 12:59:11	23	159	836	98	3763	5749	252	82.90	25	17.81	CHANGED	haohpElpcHs...........spcssWlllcG.+VYDlTp.FlccHPGG..............tcslhttAGpDsT-tF...................................................ssh...Hu..spA+phLcp...ahlGplt	............................hohpEltp+s............pppsh.al.s.l....p..G.......p......VYDlTp...ah..p....p.....HPGG.......................................tphl..h..p...h..A.......G...c...Du.Tc...t.F..........................................................................................................t.th.....Hs.......ph.h...p.p..hhpp.........hhlGpl.h...................................................................................................................................................	0	1318	2157	3127
+471	PF01814	Hemerythrin		Hemerythrin HHE cation binding domain	Bateman A, Yeats C	anon	Yeats C	Domain	Iteration of the HHE family ([2]) found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain ([1]) in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organism from toxicity ([3]). However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands ([4]). In Staphylococcus aureus P72360 has been noted to be important when the organism switches to living in environments with low oxygen concentrations ([4]); perhaps this protein acts as an oxygen store or scavenger.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.79	0.71	-4.00	189	6352	2009-01-15 18:05:59	2003-04-07 12:59:11	18	141	3149	37	2104	4919	320	127.90	17	51.44	CHANGED	shhphlpppHcpltphht.....plpptssph.....................htthtphhpplhp....hptHhptEEph......l.....aPhhp..................thtt.h.pthpp..-H.....cphtph.lpplpphhppht............................tthhphhpthhphltpHlppE-..phlhshh	...........................................................................................................phlpppH.p.tl.t.c.hhs...........pltphhsph.......................................hptl.t.p.h.h.p...t...lhp...........h.p....t.H.h.p.p.EEph......h......aPhlp............................h..tt...h...pthpp......cH...................................cphtph.....lp.pl..p.phhp.shs..............................................p.th.hp.t..h....p....t.h...h..p.h.l.h.pHlthE-phhh..........................................................	0	719	1432	1824
+472	PF00353	HemolysinCabind	hemolysinCabind; 	Hemolysin-type calcium-binding repeat (2 copies)	Finn RD, Bateman A	anon	Prosite	Repeat	\N	20.30	5.80	20.30	5.80	20.20	5.70	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.88	0.74	-7.19	0.74	-3.06	305	35811	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1002	944	173	11803	38527	14276	17.60	43	19.13	CHANGED	hGusGsDplhGusGsDhl	..............GusGsDt.LhGGsGsDhl..........	0	2356	7679	9410
+473	PF00132	Hexapep	hexapep; 	Bacterial transferase hexapeptide (six repeats)	Sonnhammer ELL	anon	Prosite	Repeat	\N	20.60	16.00	20.60	16.00	20.50	15.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.13	0.73	-8.23	0.73	-4.23	216	70883	2012-10-02 11:29:45	2003-04-07 12:59:11	19	311	5065	687	17837	54606	32792	35.10	23	25.26	CHANGED	sshIGpsshlsssshlhssspIGcsshlusssslst	.....................shlGpsshl..ss..s..s..h.....l....h.....s...s....s.....p....I.....Gcs...s.hlusssslt.....................	2	5663	11374	14981
+474	PF03129	HGTP_anticodon		Anticodon binding domain	Bateman A	anon	[1]	Domain	This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases [1] it is probably the anticodon binding domain [2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.87	0.72	-4.04	116	17881	2012-10-02 17:25:11	2003-04-07 12:59:11	15	90	4984	142	5154	13645	6909	92.50	22	17.01	CHANGED	pVhllslsp...........thh.....phstcltppLppsG.............lpsphD..pspplG..t+hccs-hhGlPahlllGpc-l..p.........p..splsl+pR....sst.cp.....h..plshsclhph.lpph	..................................................plhllslsp..............pht......phA.pc...l.....h...p.p.L...p.p..t..G...............................lc.l...p...h....D.........c...s......c....ph..G.....h+..h+.c.s-.h.h.shP..at..l....l.lGcc-l..p....................................s..spVsl+..pp..................pst...-p..................t....pl.sl..s.c..lhphl...t.................................................	0	1742	3245	4321
+475	PF03578	HGWP		HGWP repeat	Bateman A	anon	Pfam-B_220 (release 7.0)	Repeat	This short (30 amino acids) repeat is found in a number of plant proteins. It contains a conserved HGWP motif, hence its name. The function of these proteins is unknown.	20.40	20.40	20.40	20.60	19.40	20.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-7.27	0.72	-4.63	91	1454	2009-01-15 18:05:59	2003-04-07 12:59:11	10	26	5	0	1162	1453	0	27.60	65	31.14	CHANGED	AhsA.ADWChRLHGW.lhPPLL....GV..as.FTs	..........A.sA.ADWChRLHGWPIM.PPLL....GlYs.FTs...............	1	0	0	1
+476	PF00633	HHH		Helix-hairpin-helix motif	Bateman A	anon	Prosite	Motif	The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA [2]. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain [5].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.31	0.73	-7.19	0.73	-3.96	104	8740	2012-10-03 02:11:09	2003-04-07 12:59:11	18	51	4519	41	1840	8454	3232	29.70	42	10.45	CHANGED	phpshhssoh--LtslsGlGttpApslhph	...........t.asGplPpsh-pLhsLPGVGcpTAsslhs.......	0	624	1195	1556
+477	PF01079	Hint		Hint module	Finn RD, Bateman A	anon	Pfam-B_766 (release 3.0)	Family	This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module. 	29.70	29.70	29.70	29.80	29.50	29.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.45	0.70	-5.14	46	484	2012-10-03 10:25:13	2003-04-07 12:59:11	15	23	195	12	241	449	25	193.60	31	44.69	CHANGED	uEs.......SsA.A+oGGCFPGsupVplpsGtpK.lp-LpsGD+VLA...sD.ssGpllaS-VlhFlDR-s......pppcpFhsIcT-ss.cplsLTssHLlFVucsp................ssss........................pssFAucVpsGphlhl........psssptlpsscVhclst.ppppGsYAPLTspGTlVV-sVlASCYAllcscsLAHhuFuPl.Rlhpt.........................ltshhhs..................................st.pppG.......lHWYuplLYpluphlLs	.........................................................pts.GC..FP...usup.VplpsG.tp+hlc-L..psGD+VLu...hs...tpG..p.h.h..aScll...h.Fl.DR-.s...............p...t..p.ptFhsl..c...T......c...........s..s....cpLtLTs.sHLlasspps.......................sts.........................................pshFAsclpsGpplhs.......................sssttlhsspVtp...........l....sh.....t...pt....hG.hYAPLTtpG.ollVssV.lASCaA......hlp.......ppthuphsahPh.Rhh..t.........................h...............................................................................................................................................	0	86	134	190
+478	PF01634	HisG		ATP phosphoribosyltransferase	Bateman A	anon	Pfam-B_1142 (release 4.1)	Family	\N	25.50	25.50	26.00	25.50	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.92	0.71	-4.66	18	3683	2012-10-03 15:33:52	2003-04-07 12:59:11	13	11	3572	24	1021	2521	1995	161.50	36	61.55	CHANGED	l+stDIPtaVtpGtsDLGIsGhDllpEpp.....ts....VppLh-LsFGpC+LslA.lPps.t..h..pssc-ls..........thRIATpaspLsccYhccps.......................hssclhhlsGSlElu..PtlGlADuIlDLVpoGpTL+tNGL+.I..-slhc.SoAtLIss+ssh..cppcs..hlppllsRlpuVl	...................lRssDlPsaVtpGssDlGIsGcDlLhEpt.............ts....................hhp..lh..cL.....sF.....G.....t.....C.......+.....h.....sl.A.sPps......ts...h......ps..tslt............ttRIATpYPpls+cah.s.p.cG.......................ls.s.c.llp.LsGS.VElA.............P.h...h...GLADuIsDlV...............sT..GsTLcANGLc.l..-sIhc.SpApLIss...cssh.......pp..cpp...hlcpll.p+lpsh..............................	0	333	672	875
+479	PF00512	HisKA	signal; 	His Kinase A (phospho-acceptor) domain	SMART	anon	SMART	Domain	Dimerisation and phospho-acceptor domain of histidine kinases.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.08	0.72	-3.98	265	79834	2012-10-11 19:05:54	2003-04-07 12:59:11	20	3878	5148	22	22919	67684	10793	67.20	24	10.76	CHANGED	tppphlusluHElRoPLsulhshschLpp.................tphstpp..................pphlptltppspc.ltpllsclLphu+hcss	......................................hpphlusloHE......LRTP....L...s...s....l....h....u...h....s..c....hltp........................................tthsspp..........................................pch...l...p...t...l.t...p...p...s...p...c..lt.p.l.lsclLshu+hpt......................................................................................	0	7780	15044	19599
+480	PF00850	Hist_deacetyl		Histone deacetylase domain	Bateman A	anon	Pfam-B_343 (release 3.0)	Domain	Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism.  Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins [1].	20.40	20.40	20.60	20.70	20.30	20.30	hmmbuild  -o /dev/null --hand HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.46	0.70	-5.13	148	5457	2012-10-01 22:40:15	2003-04-07 12:59:11	14	64	2207	138	2589	5145	3452	289.40	27	65.04	CHANGED	H....................st......s.HP.Ess.....pRlpt....lhptLtp......s.s.........lh.th......................................................................sp.ss.pppl.t....tlH............................................................stpY.lppl......................................................pptt.pt..tt..................................................st.s.h................sstshpsu.....hhusGuslpAsc.tlh.....ps..........................................................t...cpu.....asls......RPPGHHA.p............................................t................................................................................................................sp............ut.....GFClaNslAlAAphh....................hp...hs.hp...RVhIlDhDVHHGsGTpchFh...............................................s................c.................spVhhhSlHp....s.....t..aP.....oGhh.pch.G..................................................................ttutu...tslNl.PLss........s..........ssDpsahphh...........pp.hlh.sh...hpp...............................F.pP..-llllsAGhDuttsD............sluph.slo.................spuatph...schlhphuptht...l.lhllEGGYsh.pslupsstthlpslh	.............................................................................................................................................................................................................hhh..............t.HP..pstRlp.........hhp..t..Lht...........t..s...lhtph....................................................................htsp.As...tpcl....t...hh..H............................................................s.tc.Ylphl................................................................................................................................pphp....tt.tt...........................................................................stss.h.........thhc.t.s........thusG.usl.tus..c.tlh........p.s........................................................................................................................................................................................................................psu.....h.uls..tsshHHA..p..........................................................t............................................................................................................................................................................sp..............us............G.F.Chh...N.s.lulAhphh....................................................hp..........t..hp....RVhll.Dh.............D...lH...HGs..GspphFh........................................................................................................s......................................c.................scVhhhSh...Hp................................................tthaP........ssG.th.p-h..G......................................................................................t.u.s...............hslNl..P.Lss.....G.....................hsD...t.sa.h..p.hh..........................cphl....l....hp..t....................................................F...pP...-hllls..........sGh.....Du.htsD................................Lu.p...h..s..lo..............................................p.s...as.p.h........sphl.hphu.........................................llhl...ht..GGYsh....pslspshth.ht...h..................................................................................................	0	894	1512	2100
+481	PF00010	HLH		Helix-loop-helix DNA-binding domain	Eddy SR	anon	Unknown	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.60	0.72	-4.27	164	13830	2009-01-15 18:05:59	2003-04-07 12:59:11	21	125	1653	43	7025	12625	9	53.50	29	14.63	CHANGED	pRpttsthE+pRppplNpsh.ppL+phlPp.s......................................tspK.lsKsplLchAlcYIppLp	.................................+.t+s.h...hE.R.......p..R.R......p.c........lNpt.......h.p.....p.L.+pl..lPp..s......................................................................................................................spK..h.....s....K..sslLct.AlpYlppL.........................................................................	0	1550	2941	4943
+482	PF00403	HMA		Heavy-metal-associated domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.90	0.72	-3.82	73	19664	2009-01-15 18:05:59	2003-04-07 12:59:11	21	116	4700	120	6028	15739	1631	61.20	26	16.34	CHANGED	phtl.shsCssCspplppslppl.sGV...pslplshts.pplslph....sss............pp..lhptlp........p...huap	.................hplpGM.oC.u..u.Csppl-c.sLp.p........l...s....G..V..............pp.s..p...V....s..l...s...s...p..p.....s..pV.p..h..............sssh...........................pp.....lhpslp..........p....hGa..........................................................	1	1678	3706	5056
+483	PF00368	HMG-CoA_red	HMG-CoA_red1;	Hydroxymethylglutaryl-coenzyme A reductase	Finn RD	anon	Prosite	Family	The HMG-CoA reductases catalyse the conversion of HMG-CoA to mevalonate, which is the rate-limiting step in the synthesis of isoprenoids like cholesterol. Probably because of the critical role of this enzyme in cholesterol homeostasis, mammalian HMG-CoA reductase is heavily regulated at the transcriptional, translational, and post-translational levels [2].	17.10	17.10	17.80	17.30	16.70	16.40	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.14	0.70	-5.80	116	2199	2009-01-15 18:05:59	2003-04-07 12:59:11	13	21	1868	100	595	1829	689	348.70	33	68.69	CHANGED	pculphRRphlp...phsstp..........................................lppls.tshDhp.....................................shspshENhIGhlplPlGlAGP.lhlsGct........ahlPhATTEGuLVASssRGs+slstuG.Gspstlhp-uMoRuPshth.....sltcAtphtpWlp..cshpplcphup.....sTopau+Lpclcs.hl.......sGphlalRFthsTGDAMGhNMlopusEtshphl....pcph..ss....hphlulSGNhssDKKsuslNhlpGRGKpVsAEshlst-llpp.hL...+ssscslsc.lsht+NhlGSAhuGuh...GaNAHhANhlsAlalATGQDsAplsESSpshThh-sp.ss...............-LhhSlThPoltVGTVGGGTtL.ssQptsLclLGlp.ss......sAppLAc.....IlAAsVLAGELSLhuA......Luuscls+uHhpLs..R	..........................................................p......Rhthlt........t..t.p..........................................hp.h.......pths..p.....................................lhs.phhENslGhhtlPlGls.ss.lh..ls.Gpp.........................YhV.PhsT.pEsul...VAusspGuKhlp.t...........u..G....G.hps...............hlhp.c.tM.htps...............slt.....slsc....s.t.p.h.p.thlp......pphpp..ltp..h.ss................hspRtGthpclps..ph................................ts.p..h..l.h..lcht..scTtDAMGtNMlsphhEslhsh.l....pp...h..ts.............tl..huI.uN.aso-....................phVssp.stI.shchl.pc.hh......c.s...scpls..c.lsh.spphstss.htA..h...saNtthhNslsAlhlATGpDhtsl.tu.upuh.st.h.-uphpu.............................tpLhsslolP.l..luTVGGuotl..PhtptsL.clLGst..............sAcpLAp.....lluussLAtphuhhpA......Lsu...stltpuHMpLp...................................................	1	177	339	495
+484	PF02301	HORMA	MAD2; 	HORMA domain	Bateman A, Mian N	anon	[2]	Domain	The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested to recognise chromatin states that result from DNA adducts, double stranded breaks or non-attachment to the spindle and acts as an adaptor that recruits other proteins. MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.	20.70	20.70	20.90	20.80	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.31	0.70	-4.85	95	975	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	319	45	638	916	11	183.40	20	60.33	CHANGED	o.ptStpllpchlphul..............ss...........IhYhRG..........laPscsF..pphchh...............................................s......sspss...plhp.alpp...tlh-hLppp..........hlpplslsIh................ttc......slEpapFslph.............sp................................................................hstpphppplps..........llRpls.shsphL..s.L................ct...shshclhhas...........................s...........-...hpsPh.chsps.................................p...hhss..pphpltshsTshH	............................................................tshthlpchhphul..............ps...........ILY.Ru.................lYPt...psF..pph..ph.h..........................................................................................................hspssplhp..alpp.......tltch.lppt.....................hlppl.slsIh.....................ptp...................slEpapFchph..............tt......................................t...........................................................................t.t.hs..p..plppplps...........ll+p..ls.sts.p.h.L..s.L......................ct.......h..shplhhas............................................s...........s.hpssh...p.tpp.............................hphtthts.......................................................................................................................................................................	1	196	321	493
+485	PF00104	Hormone_recep	hormone_rec; 	Ligand-binding domain of nuclear hormone receptor	Sonnhammer ELL, Griffiths-Jones SR, Bateman A	anon	Prosite	Domain	This all helical domain is involved in binding the hormone in these receptors.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.13	0.71	-5.20	86	7507	2009-11-03 19:52:29	2003-04-07 12:59:11	25	75	533	1034	3461	7141	2	187.90	19	41.59	CHANGED	phhp.ptpppph....phhpthshpphh.phhppp...hhtsscahpp.hstFp.pL.shp-ph.tlLcshahhhhhlphhtpss...........htppphhhssstth.hhphpph......................th..c.lp...........hhpphhp.phtpL.ph....sphEhshhhshlhaph.....stpphp.......chpc..h.scphpptlsssLccYh............pthphsp....................stRlscl..lpllstlp............ph...............hphhpp..................hplscla	....................................................................................................hh.....................h.tphs..phh.sp.t...lht.hlcaAKp.lP.s....Fp...pL...sh..........pD...............Q............l...tL....L.c...s..sh.h.El....h.hl....t.hshp.h...............................................tpst.lh.h...s.s.s.hh...h.s...p.p.phpph.............................................h.hhp.hhp..........................................................................hhh.ph..s....p...php.pL..pl......sppEhs....h.l.p.AllLhss........................s.t..slp...............................pspp.........lcp...lp.cp..h.hps.Lppah....................ptt.t...t..p................................................................t+h..s..cL..lhhls...tl+........ph..........s..h.t...................h......................................................................................	0	821	1092	2529
+486	PF03241	HpaB		4-hydroxyphenylacetate 3-hydroxylase C terminal	Bateman A	anon	Pfam-B_3148 (release 6.5)	Family	HpaB Swiss:Q57160 encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli [2]. HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This family also includes PvcC Swiss:O30372 may play a role in one of the proposed hydroxylation steps of pyoverdine chromophore biosynthesis [1]. 	25.00	25.00	59.60	31.30	22.50	20.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.80	0.71	-5.48	87	994	2012-10-01 23:33:27	2003-04-07 12:59:11	8	3	749	14	219	738	251	197.20	33	41.46	CHANGED	chssthh.ps.uhhphhsapu.sRhul+h-hlhGhutths-ssGs..schptVpp+luEllthtEhhhuhshAsttpuptt...sGshhPsh.hhpss+hhhsphhs+lhcllpcluuuullh..lPSps.Dhpss........-ltshl-+Ylpus.shsuc-Rl+lh+LhhDhssopauuRpphaEhahuGss.th+.htlhpths..hpsttchscphhsh	..................t.hspthh.cs.uhh+hhshQuhsRhuVKhDFlhGlhtpsh-ssGs..scaptVQscLuEllshpphhaAhu..uhsscup.h....hs...........G..salP-hthhpshRhhssphY.s+Ipcllcchsuuullh..LPSps.Dhp.sP........plsthLsKYl+Gstuhst.cRlKlh+LhWDhhuSpFGuRa.plYEhpauGs.pph+.hph.hpphp...tssphchhhshsp........................	0	82	138	182
+487	PF02185	HR1		Hr1 repeat	SMART	anon	Alignment kindly provided by SMART	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.42	0.72	-4.23	106	1359	2009-01-15 18:05:59	2003-04-07 12:59:11	11	60	288	5	738	1202	2	69.40	23	12.45	CHANGED	ptlpplpcclphEhpl+pGuEshh+h......sssppp...........hppspsplpcopp+lphL+ppLcchptpt.stpsss	.............h.hhpplp+clphEhpl+pGAENhhchh......ss-++t......................htpsptplpcSpp+..lphL+tpLpc.hptph...p...t...................	0	142	264	477
+488	PF00570	HRDC		HRDC domain	Bateman A	anon	Medline:98060076	Domain	The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.84	0.72	-4.26	147	6087	2012-10-03 03:05:55	2003-04-07 12:59:11	18	73	3520	22	1677	4778	961	67.30	27	11.64	CHANGED	phslhcpLpphRcphA.ccp..s.lsshhlhs-psLhplApt.hPpshpcLtpl...pGluptplc.caGpp..hlphl	......................tlhptLtphRcph.A.ccp.......s..lsshh.....lhsDpsLhphA..c......t..h....Pp....o....hs-lhpl....pGlu.tp.+lc..+aGpt..hltll................................	0	541	1053	1412
+489	PF03878	YIF1	Hrf1; 	YIF1	Wood V, Bateman A	anon	Wood V	Family	YIF1 (Yip1 interacting factor) is an integral membrane protein that is required for membrane fusion of ER derived vesicles [1]. It also plays a role in the biogenesis of ER derived COPII transport vesicles [2].	25.00	25.00	27.70	27.00	21.90	24.90	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.54	0.70	-5.22	6	451	2012-10-01 22:34:14	2003-04-07 12:59:11	10	7	302	0	283	437	3	221.80	34	73.12	CHANGED	hltsshss.huhtYGpslsspGpEhVcpshs+aluss+L+YYFsVsssYVspKLtLllFPahHps...............Wphphc.......p-s.lPPR.DlNAPDLYIPhMAFlTYlLlAGhtLGlQc+FoPEhLGlpASoALAalhlEllhlpLuLYLlslp..oshsslDLLAasGYKaVGlILusLssllah...uYYllhsassluhuhFllRoL+hslL...usssstshsshs...........tppp++hYhLhhlAAsQ.llhaWLo	......................................h...t.h...huhtaG.pshhspup-hhpppl.s..+al..s.s.....s.....t..L+aYFsVsstYVhpKLtL.llFPa.hHc.s.................................................Wphphp..........................ptt.hsP.R.D..lN.......u........P....DLYIP...................hMuhlTYlLluu....hhhGh.......p.......s............p....Fs.P.EhLuhtsopuls...hhhh.EllhlpluhYll.s..lp......ssh.shlD..LlA.asGYKaV...u.h.lls.l.ls.s.h.l......h......s.....t......hsa.....a.....h..s.hhashhuhshFl.........l.........RoL+hhll..........s.sss.t.t......t....................ttpph+hhhlhhhu.hh.Q.hhhhWL..........................................................................	0	99	159	232
+490	PF02793	HRM		Hormone receptor domain	Bateman A	anon	Bateman A	Family	This extracellular domain contains four conserved cysteines that probably for disulphide bridges.  The domain is found in a variety of hormone receptors. It may be a ligand binding domain. 	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.80	0.72	-3.96	131	2035	2009-01-15 18:05:59	2003-04-07 12:59:11	17	119	140	37	924	1697	0	64.90	28	8.33	CHANGED	s.hCstsaDsh.hCWPpsssGphsshsCPphh...t.pt.........................pu.....pspRpCsts....GtWsph...........sshspCtt.	.............................t..hCstpaD.th..hCWP.potsGph.s.thsCPp.hh.......t.......................................................pG......pshRpC.sts......G....Wsth...........s.sshspCt.....................................................................	0	149	213	503
+492	PF01381	HTH_3		Helix-turn-helix	Bateman A	anon	SCOP	Domain	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.58	0.72	-4.12	175	36941	2012-10-04 14:01:11	2003-04-07 12:59:11	17	294	5111	176	7651	48830	5885	53.20	22	32.31	CHANGED	l+phRp..ptshop..pplActhG..lspstlsphEpG....pppsshptlhpluchls.lshshl	.............................lpthRp....pp..s..l.oQ........pcL..A.c.t.hG............lo.p..s.s....l....u....p..h....E......pG........pp...p.P...s....h....p..h....l...h...p.l...uphhs.hsht....................................	0	2481	4888	6400
+493	PF01402	RHH_1		Ribbon-helix-helix protein, copG family	Bateman A	anon	Bateman A	Domain	The structure of this protein repressor, which is the shortest reported to date and the first isolated from a plasmid, has a homodimeric ribbon-helix-helix arrangement [2]. The helix-turn-helix-like structure is involved in dimerisation and not DNA binding as might have been expected [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.46	0.73	-7.61	0.73	-3.86	49	5913	2012-10-02 18:44:02	2003-04-07 12:59:11	16	35	2497	74	1378	3973	439	38.40	24	37.71	CHANGED	plolplscchhcpLcchuccts.hS+Sphl+tAlpphhpp	.............lslplsp-hhcpLcphu.......p..p...p...s..ho+.S.cll+chlpphl.............	1	404	897	1169
+494	PF02954	HTH_8		Bacterial regulatory protein, Fis family	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.63	0.72	-4.41	86	19848	2012-10-04 14:01:11	2003-04-07 12:59:11	14	176	2830	54	5558	15626	3713	41.30	31	9.21	CHANGED	tlcc..lEcphltpALcpsssshscAAch.LGloRpoLth+l+ch	........................tp.hE+phIppsL..p...p...sp...G...s......h...s...c....A....Ach.LGl.s...RsTLhcKlcch................	0	1884	3516	4654
+495	PF04005	Hus1		Hus1-like protein	Wood V, Bateman A	anon	Pfam-B_12502 (release 7.3)	Family	Hus1, Rad1, and Rad9 are three evolutionarily conserved proteins required for checkpoint control in fission yeast. These proteins are known to form a stable complex in vivo [1]. Hus1-Rad1-Rad9 complex may form a PCNA-like ring structure, and could function as a sliding clamp during checkpoint control. 	20.60	20.60	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.81	0.70	-5.47	34	342	2012-10-02 11:47:48	2003-04-07 12:59:11	7	8	284	3	231	353	3	286.70	24	90.95	CHANGED	M+F+splss...hpphpcllsslupluKhChl+LsssplhFll.t........sssGsQlWsplphss...lF-..pYp.lpSs.sp..spIsLEl.slssLhRAL+oups..............us..s.........................lpl+Ls++............tphPhLslphpssoh.........................................................tppslsp..-lPVclL.sppphpplpEPph.-sDlp...IhLP.sLhpL+sll-+h+pl................................ushlplpAs...........hpGpLp..........................Lslpo-.hlsloopa.psLtsstht.t..............................t.t.tttssspt.sptthsplpVDhKchsphLp.stplssspslhslsccpslhlhhhh.......pcsslpaalPuhs	..........................................M+F+s.l.s.........hphhpphhsslspL....t......K..h.s........h......l+lsspplphhht...............sssusplWs..pl.t..h.pt...............lFp..pap.hp..us..st...................NpIhlEl.shpsLtRAL+oups.......................................up......s...........................................hpl+Ls++..........................tphP.h.Lslshp.h.sh..................................................................tp.pphlsp...-lPVcll..p...pth...p.plp......p.Ph..s.s..p........s...-lp.....l.h.LP....s........Lt........p........l+..sll-+hcpl.........................................us.hl........lpAs...............hpG..pLp........................................Ltl.po-....h....hplsoha.ps.Lts....h........................................................................t..ttt....p..p.....t.tthspl..plch+ch.phLt....stph.p....spslhs....................lhppp...hhhh..hhh..................pss.lphhls...s....................................................................................................................................	0	77	128	192
+496	PF03810	IBN_N	IBN_NT; 	Importin-beta N-terminal domain	Griffiths-Jones SR	anon	PROSITE	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.70	0.72	-4.06	52	2930	2012-10-11 20:00:58	2003-04-07 12:59:11	14	77	330	59	2037	2826	22	72.40	20	7.63	CHANGED	AEptLpphppp..Psah.tlhpll.p..ps.s.psR...hhAulhL+shlpp+..Wp..................plstpp+ptI+spllphlhp	..........................................ApptLp.phpp....p...s......s..hh..hLh......pl..........l............s.......p.............s................s......................t..........s.R.............hh...A...ul.hL+sh..l....p..pp....Wp...................................t.lsppp+t.tI+ptllphlh.p.........................................................	1	655	1084	1648
+497	PF01485	IBR		IBR domain	Bateman A, Mistry J	anon	[1]	Family	The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (Pfam:PF00097).  This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain [2].  Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms.  RBR family members play roles in protein quality control and can indirectly regulate transcription [3].  Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes.  The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease [3][4].	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.68	0.72	-4.10	166	4521	2012-10-06 20:19:25	2003-04-07 12:59:11	16	133	321	4	3180	4384	29	66.80	23	18.68	CHANGED	p+...a.ph...................tppph.........p..aCPs.ssCpthlthpptspp..................................................hpCs......Ct.tpaChpCppth....Ht..........sh..sC	..............................................................................................t.ph...........................+....hC.Pp........Cp.tsl..pt..s.s.sssp..............................................................................................................hpCs..t...........Ct..tpF.Ca..h..Ct..t.t.h......Ht.....................................................	0	984	1588	2459
+498	PF01614	IclR		Bacterial transcriptional regulator	Bashton M, Bateman A	anon	Pfam-B_755 (release 4.1)	Family	This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. These proteins have a Helix-Turn-Helix motif at the N-terminus. However this family covers the C-terminal region that may bind to the regulatory substrate (unpublished observation, Bateman A.).	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.35	0.71	-4.45	23	10733	2012-10-02 14:34:25	2003-04-07 12:59:11	13	33	2457	47	2964	8004	908	124.00	23	46.91	CHANGED	tphpss.tlGp+lPlauouhGKsLLAah.sccthpphlcp..hphpphTptTlos.psLhcpLsplRpp.GauhssEEpptGltulAAPlast...puplluAlSlossssRhscpphpp...hhshlppsApplopp	.............................................................................h....h..tlGp+.hP.h..a.s.o.uhG+slL...Ahh...sp....p.p...h.p.p.h...l.pp..............t.h...p....t...h......o.......t....p..........o.....l...s......s...............t.......t...L....h.....p.......p......L....t......p.......lR.......c....p......Ga.u......h...........s...........p..........p......E..h..p............G.....l.p.....slAs....P.l...h..st..........pG.p...sl...u...Al......olu............u....s...s..t...R..h...sp..p..p.hpp..........hhs.hlhpsAppls..t......................................................	0	689	1722	2433
+499	PF04760	IF2_N		Translation initiation factor IF-2, N-terminal region	Kerrison ND, Laursen BS, Studholme DJ	anon	DOMO:DM04974;	Family	This conserved feature at the N-terminus of bacterial translation initiation factor IF2 has recently had its structure solved.  It shows structural similarity to the tRNA anticodon Stem Contact Fold domains of the methionyl-tRNA and glutaminyl-tRNA synthetases, and a similar fold is also found in the B5 domain of the phenylalanine-tRNA synthetase.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.33	0.72	-4.31	141	7695	2012-10-04 14:01:11	2003-04-07 12:59:11	10	48	4486	1	1683	5556	2986	52.00	26	10.04	CHANGED	.splpVp-LAccls.....h.ssp-llcpL.p.h....Glt..tshsssl-p-psphltpphshp	.........pplsVtELAcchs.......h.pss-llcpLhp.h........Ghh...sohsps.l-p-.s.hphlspchsh...........................	0	547	1098	1438
+500	PF05198	IF3_N		Translation initiation factor IF-3, N-terminal domain	Bateman A, Finn RD	anon	Pfam-B_629 (release 2.1)	Domain	\N	21.30	21.30	21.40	21.30	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.11	0.72	-4.05	181	4308	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	4162	1	1055	2633	2165	67.60	52	37.87	CHANGED	ppp...plN-cI+.s..pcVRLl.spcGcplG..................llshp-ALc.hAc-tsLDLVclu.........PsAcPPVCKIMDYGKa+Y-ppK....Kp+Eu+	......................hNpt.Ip.......plRll....s..p.Gcp.lG..................................lhshp-ALp.hAcct.sLDLVclu...........Ps..Ac.P.PVC+IM...D...YGKF..+YEppK....Kp+Et+.......................	1	369	701	898
+501	PF05004	IFRD		Interferon-related developmental regulator (IFRD)	Moxon SJ	anon	Pfam-B_4730 (release 7.6)	Family	Interferon-related developmental regulator (IFRD1) is the human homologue of the rat early response protein PC4 and its murine homologue TIS7 [1].  The exact function of IFRD1 is unknown but it has been shown that PC4 is necessary to muscle differentiation and that it might have a role in signal transduction. This family also contains IFRD2 and its murine equivalent SKMc15 which are highly expressed soon after gastrulation and in the hepatic primordium, suggesting an involvement in early hematopoiesis [2].	25.00	25.00	25.20	25.60	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.98	0.70	-5.34	7	396	2012-10-11 20:00:58	2003-04-07 12:59:11	8	7	219	0	250	334	1	275.60	27	66.11	CHANGED	SD--us.pohS....s.s..ssuu.s-.hss.ht-thtppclE-pLcptlDtsp-KS...ApsR.psLctlphhl.s+hh.-Fl.-chhTLh-hlp+sh+KG+u.cEphLusplhuLlslQhGsG.cs-Elhcphts.LpsllpDu.otuhpsRtpCsoslulhsalussDspplht..tshc.lFthsa.h+sssss.Vlsst...slhusuL.AWuLLL......Tlsss.ph..phhppphstLsp......LLpusslslRlAAGEslAllaEhup............sh-p-.........F..hh-...shEpL..........sphLRpLAoDS.sKh+AK+D++tQRssFRDVlchlE	.............................................................................................s.......t......t.p...............t...h...ptst...p...pph.p........t...Lpthl-th..h-Kp......sp.sRpsuLpulhph....ht.s+..h.h..........-...hl...c...+hhT.Lhcsht+sl..........K+.Gp......u...c.....E........p..t.h.A.hthhsllslph.s.s.....p.................sc.clhc..p........hts.hL.................pp..hlp.Ds....sss.hp.....s...........ss..hp..sLulssal..us.s..-...p-h....pshc.ha.h.h..hp..tss.p.........h..sst....tsslhsuA.lpuW.ulLl.........................Thh......s.s....plp....p......h....h........cpt........h....t.t..Lss..........lL.p.u.s..-hs....lRlAAGEsl.....ALl..aEhup..........................................s.pp-........................................h..hh.p......shptL....................................hphlppLAs....-......u..sKtt.uKpD++p.Q.RusFRsllphlE......................................................	0	64	125	193
+502	PF00817	IMS		impB/mucB/samB family	Bateman A	anon	Pfam-B_1349 (release 2.1)	Family	These proteins are involved in UV protection (Swiss).	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.70	0.71	-4.41	113	9024	2009-01-15 18:05:59	2003-04-07 12:59:11	15	52	4250	224	2364	7309	2792	150.20	30	34.04	CHANGED	lDhDsFaAosE...thhp.......P..pL..cscPlsVssttt.................................................uhlhsssYtARp.hGl+su.MslhpAtc..l...............C...P.p.l..........lll..................................ssshshYpchSpplh.pllpch.s............lchhS.lDEsal........Dlos..h.phhss...............................................................................................................pplupplccplhcph.t..lssSlGlusschlAKlAoc	...............................................................................................lDhcsFaAulE..........hhpp............P......pL...pspPl..sVuus.t.p...........................................................................................tGllh.sss.h........p.A.+.p..hGl.+.su.hs.h.h.p...Ahc...h....................................s........P...p..l..................................hhl............................................................................................................................sss.h.phYtc..hS.p.plh.plh..pc.a..o......sh........................lEs.h.S..l....DE.ual..............DlTs........shp..hh.s.s.....................................................................................................................................................................................................................................................................tp.l.u.ppl+ppl.h..p.c.h..t.....lssos..G.l.u.s..s..KhLAKlAs...................................................................................................................................................................................	0	760	1436	1969
+503	PF04836	IFRD_C		Interferon-related protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4453 (release 7.6)	Family	Family of proteins thought to be involved in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF [1].	20.30	20.30	21.30	20.30	19.20	20.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.71	0.72	-3.79	13	196	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	99	0	108	166	1	54.50	53	13.18	CHANGED	NEhLR-lF-LGPslh...sssh+shKlo+hE+HhhNuAAFKARTpsRuKhRDKRusV	........NEhLR-lFpLGPslh...sssshKshKlSRhE+HLaN......uAAFKARTKuRuKsRDKRuDl....	1	24	40	71
+504	PF04762	IKI3		IKI3 family	Wood V, Bateman A	anon	Wood V	Family	Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation [1]. This region contains WD40 like repeats.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	928	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.64	0.70	-13.77	0.70	-6.74	34	404	2012-10-05 17:30:42	2003-04-07 12:59:11	7	9	257	0	291	526	10	666.90	27	69.81	CHANGED	MRNLpslspsphp.tsps.........hslhso..saDsso-slhhshu...ssps.sslElpphtpss........th.thlssa....................sclluhpahsD.......spplshshssGDllhsp.t.............ssspshlEIVGol-sGIpAusWSPDEEllAlsTtp.............psllhM.o+pFEslsEhsLs..s-Dlph..SpaVoVGWGKKETQF+G+t..uKA..................................h+DPThs.pl-pGtlot.Ds.tpssISWRGDGpYFAVool..css...........RRslRVasRE.Gp.L-SsSE.sVDGL...........EpsLuW+PpGsLIAusQ..R.pscp............h-lVFFERNGLRHGEFsL+h..st-Etl.....................hpLpWNuDSslLAl..hh.........p-c.............lQLWThsNYHWYLKQEl.h..t...t.............hpWcsE..+shplhssss..spl.hh-asapsspussh.stD.Gh......ssVIDGpplhlTPhphusVPPPMuhtclphs..........sslh-lAhutsspp............hAslspcs.lhhht..shpth..............................stpPhltsphsh.........t.tst.tph+plsalscs....plhllhsss.........................hsclhlhph.t-spp............hhhpphsphppllhhhspsshpt....hhhpsh.sGplh...........plssptphp.h.............phPphs.phclsthpsst................hhhhGL.ossG+LaAssphlu........sssTShhl..........T.................................psaLL.................aTTspch......................................LpFlcLs..............phpthtls.ssst.......DER....sRpIERGS+LVslhPoc.huVVLQhPRGNLETIaPRhhVLuslRph..lc....pccY+cAFhsCRopRlDlNIlaD.asP-hFhpNlth....FlcQlpclsalsLFlS..sLp-EDVTp..ThY+-sh...................................hp..ttttthhtsspsoKVNplC-AlLpsL........sphhspalpsIlTuasppsPPsLcsuLplltpLpt.......................sstps-pAlcalsFLsDVNpLYcsALGlYDlcLsLhVAQpSQ+...DP+EYLPFLppLpphsphc.R+FpIDcaLp+apKALpaLtphs	....................................................................................................................................................................................................h...........................................................................................lhsh..h.t..........hhhh.ttGplhhh................................tt..h-hhs..htsGl.shtWSsDt-hlhhhTt.t....................tpllhh.s.pta-sl.....-..ht...pt.t..........tt.lshsa...Gpp.pTQFpGp..hp.............................................................ttspl.oWR.GD..utahul.s...h....s...................................................hRhh+la..s.....R......-.....h.........L...pss.....u...E...h.....ssh..........................................t....sl..sW+Pp..G..s..hIAshp...p..h.pp...............plsFaE.+.N.GL.h.Hup.Fs..l.............tp...h......................t.l.Ws..ssSplLAl...h.............tsh...........................................lplWs.h..t.NY.Ha....YLKppl...h.................................hhWc......pshphhhh.....st...............................th............hphhathst..u.....................p.u......................shVlDG...pplhlTs....hp.s.............lPPPhs.hph.h................t.s.h..tlsh..p.........................hshh.tpt.l.hh..............................................................................h............................h..hhh.ttp.....hhhh....t................................h.....................................................t.....h..s....t............hhhp.........tuphh.................................t.........................t..s...h...hth.h.httt......................hhhul.s.ppttha.h.....s..t............ls....................pshoSh.h..........h............................................tall.....hTs.....p.p.................................................................h.hh.lt................................h........t.........................t....................hRt.lERGuhllsshspp.htllLQhsRGNLEslh.RhhVLs.lt.p...lt....th.....atpAh.hhRp.+lshsllh..D.a.tsp...Fht.p..ht......Flpp........l........tp.......p..hls.Fhs...................pL.........pppshst..shY...h...............................................................tpKlshlCpthht.hh.........................tp.h.sllTsasppt.s..t.lp.sLthltpht..........................................................t...t-pu...lpal.hhL..-sptlap.uLuhY-hpLshhlAppuQh.............DP+EYLPaLpp...Lpt...................................h.p.....pa.ID.hLtpatpAltpL.t..............................................................................................................................................	0	106	165	244
+505	PF00478	IMPDH		IMP dehydrogenase / GMP reductase domain	Finn RD, Bateman A	anon	Prosite	Domain	This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel  structure. In the inosine monophosphate dehydrogenases 2 CBS domains Pfam:PF00571 are inserted in the TIM barrel [2]. This family is a member of the common phosphate binding site TIM barrel family.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null --hand HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.10	0.70	-5.56	84	7826	2012-10-03 05:58:16	2003-04-07 12:59:11	20	15	4695	86	1800	6840	6242	406.30	38	94.26	CHANGED	cuLTF-DVLLlPstotlh.scsclshp.....lo....+plpLslPllS.AsMDTVTEt.cMAIuhAptGGlGl.IH+.Nhohc.pQsptVccVK+.h-sshlpsshhhtPptpltps.thhtphthsuhslspttt.hhhlht....h.................................h.ppphlss..shshtps.phh.pp+htcl.lVscpspLhullohpDh.+sppaPpAs+....DppspLhluAAlGststshcRhpt..Lsc..A..Gl..DslllDoAHGaSpthlchl+tlKppaP..plplIAGNVsTs-uscs.LIpAG.ADulKVGlGPGSICTTRhVsGVGhP..QlTAlhcsAcsAcph......G....lPlIADGGIchsGDIsKAlAuGAssVMlGShhAGTpEuPGEhhh.hsG+paKpYRGMGSlsAMpc............GSscRYhpts......tpchVspGlpGtVPaKGslpchlhplhuGL+.uuhsYsGupslp-L+cps.......alRlosAth.EupsH	............................................................................................................................................................................................................................................................................p.uLTF-DVLLlPu.c.......Sphlssps-lsop..........................ls....cs..l.pls.l...P.l.l.o.As.MD......T.V.T....-s..chA...IAhAp..p.G.GlGl.....l......H......+...s......h......o...h...p......pQ.A...p....p....V..ccVKc..csshh.ss.hh..p..h.th..h.tt.thsshsl.tt.....hh....................................................................hhh..s.t.......h.t.ch.ph..hstt..h.shlhhpch.p..phPp.us+.....D.p.pu.+..L..h..V...u..A...A..l.G..s.........s...s........s.....s.........h...-..R....s....c..t.........L.l.c....A....G.....l........D....h.....l.....l.............l............D...........o.....A.......H...........G...H...........S.......p..t...........V.......l.......p.........h...........l.....p.......c......l...+..p...p..a..P...........p......l.p...l...I...A.GN...Vu...Ts.-u.scs....L...h.c.A.............G..A.Du......V.K.V.G.I.G...P....G....S....I.C.T..T..R......l...........l......s.G..........V.....G.s.P....Ql.o.A...lh.-.s...A....p....A.....A..+.t..h...............s........h.PlI..ADGGI+huGD.l..uKA..l...A..u.GAs....s.V.MlG..S....h....h.....AGs.-Eo.P.G.....-h..hh....h...................pG.........+.p...a.....K...p.......Y.hGMGShsA.Mpp................................GutsRYFpts........................tpKh..VsEGlcu.p....Vs.a....+Gslpshl..hp..hhGGLR.S.uhuYsGutslp-Lppps........pFlclss.uthtEut.........................................................................................................	0	567	1087	1490
+506	PF03941	INCENP_ARK-bind		Inner centromere protein, ARK binding region	Wood V, Griffiths-Jones SR	anon	Pfam-B_67765 (release 7.2)	Family	This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of  chromosome segregation with cell division in yeast.	20.60	20.60	20.60	21.00	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.75	0.72	-4.12	20	272	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	207	13	206	269	2	57.30	33	6.18	CHANGED	-IsSDs-s--sst.....hslsuWAcuspL.cptlhcQtth...DssplFGsIsPLclEEIFps	..........................-ltSDsps-D-sp.............p.p..slP..sWAc..uspL.pptlhpQtth.....-spplF.G.s...l.....s..hphE-lFt......................	0	68	112	169
+507	PF04179	Init_tRNA_PT		Initiator tRNA phosphoribosyl transferase 	Wood V, Finn RD	anon	Pfam-B_16986 (release 7.3);	Family	This enzyme (EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the  modification donor. As the initiator tRNA participates both in the  initiation and elongation of translation, the 2'-O-ribosyl phosphate  modification discriminates the initiator tRNAs from the elongator  tRNAs [1].	30.00	30.00	41.80	33.60	28.10	28.90	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.82	0.70	-5.62	20	202	2012-10-02 20:12:17	2003-04-07 12:59:11	7	6	165	0	148	203	4	381.70	35	89.56	CHANGED	pL++ssLSlpNRLpSIhpDupFVcc.Vssta.pLPLVANERCGtWYlsPchcusSuYFKSTDGHTuQWsFShRRLNLHLLsllscpsGhlIVDSTRRGKhMPDALSKTlPIWCAVlNpsla.spsp.............................phLhhPPphVusSEcspItp+.lstFVppLppL.tlDlppLpppl......pKPlRPhWh...............sscshhpssh.p.ptpsahsllLCTuS++sp..............suphpc.......sG..YlQGAuDDcEtWAp......GLTPslFW........sspppL..lsp.........uE--LsshlspLlppppppssspsst...lts............................ssslhlGthss...................tspashVlshssp.h.t.......psppppsppLphshtuuKhGS+pLRptLsplpsFlptphus................spplllsC-oG..+DlSsGlhLsllChaaspchp.........................hpt.......t.splsKphl+ppLshlhp.h...plNPSRuTLpSVNuaLM	........................................l++psholhNRLpSI.tDutFlpp.lttha...t.................h......PLluN.RCG.WYhsPpt..h..t..s.o....sYFKSTDGHhspWsFShRRLNlpll.h......h....tpps.Gh.....llVDSTR+.G.KthPDALSKTlPIWssVlNpsl.h.pt...t......................................................p.lhh..Ps.hlstoEcspIpp+.lstastplp.......ph...ths...h.tpLtttl......tKPlRPhWh.....................tsps..h....s...p........t.....tt....sahsllhsoASp..psp...............ss.t...pc.........hu..YlQGAuDDpE.Wuh......GLoPslFW........tptp.L..hss.........scppl.sp.hl..tplltpppttts.ttt......lt..............................................................sppl..lsthts....................................t......hs.h.ll.hstp......................s....pt.thlph.h..s.ssKhupp.....t.Lcp.Lsph.thhtt.htt.................................t.tlllh..C....p..sG..p.Dh..SlushLsllshh...as.p.ph..........................h.t........t...h.s....K....l..+p+Lshlhp.h....pspPSRssLppVpsaL...................................................................................................................................................	0	49	89	127
+508	PF02022	Integrase_Zn		Integrase Zinc binding domain	Bateman A	anon	PSI-BLAST 1wjb	Domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  This domain is the amino-terminal domain zinc binding domain. The central domain is the catalytic domain Pfam:PF00665. The carboxyl terminal domain is a  DNA binding domain Pfam:PF00552.	21.00	21.00	21.50	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.85	0.72	-4.51	92	14892	2009-01-15 18:05:59	2003-04-07 12:59:11	14	72	180	53	30	13552	0	39.60	77	6.93	CHANGED	ApE-Hc+aHsNh+sLppcFslPthVA+cIVppCspCphpG	........AQEEHEKYHSNWRAMASDFNLPPlVAKEIVASCDKCQLKG.....	0	10	11	12
+509	PF00520	Ion_trans	ion_trans; 	Ion transport protein	Finn RD	anon	Pfam-B_33 (release 1.0)	Family	This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is  repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.53	0.71	-5.07	285	20399	2012-10-03 11:11:44	2003-04-07 12:59:11	26	434	1652	37	9781	20841	2116	196.60	17	31.06	CHANGED	hhshlhsslFshEhll+hhuhsh......................hpYhpssaNhhDhlsllsshlshhht.ht.........................................................hthlchhRhh...R...hl+lhphhps....lptl.....ltslh.pshtslhplhllhhhhhhlaulhuhplatstht.t.................................................................................................................ptpssFcshstuhhhlapshTstuasslhhsh.............................shhshlahhhhhhlsshhllNlhlull	..........................................................................................................................................................................................hphhhhhhFs.h.Eh..h..l.....+.h..hshs..................................................................................ht.ah...p...s.....h....a.s....h..h....D...h..l....h...l...h...h...s....h.l..s.h..h.h.t.ht.............................................................................................................hp.hl.R.h.h.R.hh....R...............hl.....+..l....h..p..h...h....p...t.........................h..p..hl.................l......s..l..h....p......s...............h.......t...s.........l...h.....p.....l..h........l..l.........h....h...h....h...h.h........l...a........u....l..h..u..h...t....l....a...t...t...p...h....t.................................................................................................................................................................................................................................t..t..t....p.F...s...s...h......h....t..uh...........h.h...l.........h.........p.............h...............h.T..s...t....u....a.s..s..l.h..t.............................................................................s.h.h.s.h...l..ah....hsh....hh..l..s.s...h....h..hl.sl.hlul..........................................................................................................................................................................	2	2792	3895	6681
+510	PF03770	IPK		Inositol polyphosphate kinase 	Finn RD	anon	Pfam-B_1382 (release 7.0)	Family	ArgRIII has has been demonstrated to be an inositol polyphosphate kinase [1]. 	22.20	22.20	23.50	22.30	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.31	0.71	-4.67	109	1104	2009-01-15 18:05:59	2003-04-07 12:59:11	11	19	318	15	725	1054	13	210.70	27	40.30	CHANGED	allLEsLstsappP...CVhDlKhGsRpas.-....As................................pKtpp.pp+sppoTStpLGhRlsGhpla.p......................................ppst..hh.....phsKhaGR.slstp.phpculppFltss............thppttthht.....thlp+Lpplpshlcppct....aRhYuSSLLhlYDuc...................................................................................................................................................................t..spscl+hIDFA+.ssh................hsssshDcGaLhGLcsLlphhp	.....................................................................................................................................alhLEsls..t..t.......ap..pP...ClhDlKhGsRpasp-...ss.................................................................................................................................pKhpp..t.+pptooossLGhRlsGhpl...ht................................................................................................tpst.....h.......hhs.K........a.G+..s....h.s.hp..ph.p.p.s.lpp.Fht...................................tp.l..ht.........................hlp+Lpplpp...hlcppp....................achhuSSLL..hlYDup..................................................................................................................................................................................................................................................................................................................................................................................................................................................ttsplphIDFA+sh...................................................h.tts.Dc...GalhGLcsLlplh.................................................................................................................................................................................................................................................................................................................................................	0	250	366	558
+511	PF00612	IQ		IQ calmodulin-binding motif	Ponting C, Schultz J, Bork P	anon	SMART	Motif	Calmodulin-binding motif.	20.30	11.10	20.30	11.10	20.20	11.00	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.00	0.74	-6.85	0.74	-3.79	345	16654	2009-01-15 18:05:59	2003-04-07 12:59:11	22	705	467	44	8271	15224	358	20.70	32	5.40	CHANGED	ppuslhlQshhRuahsR+pap	.........pAAlhIQuhaRGahsR+ph...........	0	2330	3800	5778
+512	PF01007	IRK		Inward rectifier potassium channel	Finn RD, Bateman A	anon	Pfam-B_18 (release 3.0)	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.12	0.70	-5.65	13	1452	2012-10-03 11:11:44	2003-04-07 12:59:11	15	11	294	52	764	1256	32	284.90	37	78.63	CHANGED	VpKsGpCNVpasNlptc.ptRYLsDlFTTlVDlKWRapLllFshuFlsSWLhFGhlaWLIAahHGDLpt..................ssstTP......CVtsVpuFsuAFLFSlETQTTIGYGaRslTEECPlAIhlllhQuIlGsIIsuFMlGshhAKhApPKKRAETLhFScpAVIuhRDGKLCLMaRVGsLRKSHlVpAplRupLl+s+pTpEGEhlPLcQhDlsVshDsGs.DplFLVoPlTIsH.IDcsSPLa-luppsL.pppDFEIVVILEGhVEoTuhTsQARoSYlscEILWGHRFpPVloh..EcGhYcVDYSpFcpThEVs....TPtCSA+-LsEpK......Lhpshp..........sh-sph	......................................................................................................htKsGpsNl..h.t..p...h...t...p...................h.a..ltDl..aTThlD...h.p.W.R.a.hh.lFshsahho..W.hh.Fu...hh....aahlA...hh+G..D....l......................................s..h..ps.......C.l...p.l...p..u...FsuAFLFSlETpsTIGY.Gh....R...h.lT.-.cCP.ulhll.l.h..QsllGh.llsuFh............h..GshhsKhupP+...+..RA.p..Tlh.....FScpAV...............I...u...hR......c........G...+.L..CL....MhR..V..u..s......hR.......p..Sh..ll..p..upl..+s.p.L.l...+...s.p.......T.....E.G..E.....h..l....l.pQ.h-.l.s................l..sh.s.......t...u................c.....p..lFLl.P..l.....slh.H..ID.ppSP......lash.......s.t.p.....s.........l.....t.p.p..c..FE...........ll...............VhL-GhsE..uT....u.........h.o.s.QsRoSY.l........sp..E..IhW..............GaRF.s.ll....................c......p..s..hY..p...l.Dasp..Fp..psh.ps.......sP.......h...s.hh.............................t...............................................	1	170	277	492
+513	PF02174	IRS		PTB domain (IRS-1 type)	Bateman A, Mian N	anon	IPR002404	Domain	\N	21.00	21.00	21.10	21.10	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.14	0.72	-4.40	32	923	2009-01-15 18:05:59	2003-04-07 12:59:11	12	28	105	45	552	834	1	96.60	28	10.89	CHANGED	ptstF.V.lp..........hptsupcssl.pGsh.hLplopcsLhL............hpsppshlpWPhptLRRa........Gp.s..pshFoFEuGR+CsoGtG.asFpspc...upp..laphlppshps..pp	...................................t....a.V...............h.....s.....pt.sh..hG.s.h...hLplTp..c.......slhl.................sptpsc.psh..hpWsLpslRR..a.............Gt..s..sshFohEsG.Rp..sssG...Gh.a.thpssc......upp...I..aphltphhpt...t.........................	0	117	160	311
+514	PF02922	CBM_48	isoamylase_N; Isoamylase_N; 	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	Griffiths-Jones SR	anon	Structural domain	Domain	This domain is found in a range of enzymes that act on branched substrates - isoamylase, pullulanase and branching enzyme. This family also contains the beta subunit of 5' AMP activated kinase.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.28	0.72	-3.94	59	8560	2012-10-02 20:10:03	2003-04-07 12:59:11	13	125	3303	51	2144	6979	701	85.90	27	11.95	CHANGED	sLGuph...........sspFplWuPsAppVplhh.hss.....h.tpphshp.....tpsGlWplhls.......sht.......t.hYtaclpsss......................G.....hhhhhDPYA	...........................hGuphpst............GspFsl.WA...P.s...A.p.pV..pls...s.hss..................ht..t.p..p...hs.hp............tpssGlWc.h.hls...........slt.G......................t.hYpYclpsst.......................G..........hhhhhDPaA...............................................................................	0	684	1346	1804
+515	PF00857	Isochorismatase		Isochorismatase family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_566 (release 3.0)	Family	This family are hydrolase enzymes.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.87	0.71	-4.33	64	13319	2009-09-13 17:43:14	2003-04-07 12:59:11	15	81	4229	124	3488	9497	1254	172.10	20	81.06	CHANGED	sALl..ll..DhQ.pshh............tstphpphltshpcLlcsu..+pts.....hs....llhspphhp.................................hhh.ss.ssplhsplps......s-hhlp...Kp......phsuF.......hsosLpphLcp...psl..c...plllsGhtTphCV...tsTshsAhpp.Ga.....plhllsDu.....suuhs......spt.pptulppht......hh.uhlhsspp	.........................................................................................................................ALl.llDhQ..pshh...............................hsh..ss...t..sp..p....ll..s.s..l....s..pL...h.p..t..s......+.t.t.s..............hs...............llhspphtt............................................................................................................s....h...h..h......s..s.........s..t....p...........l..h.......s...........p...L.......ss.............schl..lp....................Ks................phuuF.......................................tsTs.Lp.p......h.L.+p........p.ul.....c...............pll..lsGltTchCV.................tpTs..h......s......A......h.......ph...Ga...............................pl.hllpD.A.....su.shs................tpt..pphul.t.tht...........thh.s......................................................	1	1002	1990	2805
+516	PF02373	JmjC	jmjC; 	JmjC domain, hydroxylase	Bateman A, Wood V, Mistry J	anon	[1]	Family	The JmjC domain belongs to the Cupin superfamily [3]. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification [4]. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation [5].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.21	0.71	-3.84	32	2778	2012-10-10 13:59:34	2003-04-07 12:59:11	17	174	310	95	1692	3393	72	108.20	25	10.42	CHANGED	hlYhG.hhophsaHhEspshhS...lNahchsus+hWaslPsppspphc...phhpcp.......h.tp.th.lpphsshhsPph..LhptslsshchsQcsGEhVhs.stsaHsshNhGashu.uhNF	..........................................................................hhhuh.hot..hs.h.Hh-.stt.hh.u.............ls..a....h............h.........h..........s....us......K.......t...W......a...hl.P.s.p...p..t...p...p..hc........chhpph..........................tp..h....lp.hh...hs...h..h....sph.........lhp.h...s..l......s......h.c.............h..hQps...G-hlhh.st..sh.H.t.......s..hNh.G.h.s.hs.uhNF.............................................................	0	478	771	1239
+517	PF02099	Josephin		Josephin	Mian N, Bateman A	anon	IPR002950	Family	\N	19.90	19.90	20.20	21.00	19.40	19.60	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.19	0.71	-4.60	10	651	2009-01-15 18:05:59	2003-04-07 12:59:11	12	14	168	8	262	634	1	135.20	47	52.38	CHANGED	+Q-us..LCAlHCLNsLLQ............................GsaFocs-LusIApcLDppEcsphsp.....sspsstoaht..csSpNhspsG.FSIpVLppALclWsLpllsa..psschpstph...cP-spsuFIhN..........hscHWFsIR+l.........supWaNLNSlLuA.PcaIucpYLusFLcplcupGaSlFlVps.s	........................+Qctp..LCA.HsLNNlLQ..............................................................................................u.p.hFo..pLspIsppL.s.pph.h..............................th....psp.tN.h...ss........G.aslp..........VI.......sALp.s.hu.hchl.a....s.c..h..phhtl................s...p.huFIhN.......................................hccHWhslRcl.........................................s.tpWaN...LsShLsu..P-..hI.u.-..s.h..L..t.hFL...s.p.l.p..p..p.G.h.plFlV..s...........................................	1	94	133	200
+518	PF02214	BTB_2	K_tetra;	BTB/POZ domain	Bateman A, Eberhardt R	anon	Pfam-B_27 (Release 5.2)	Domain	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.34	0.72	-3.78	46	3855	2012-10-02 01:20:04	2003-04-07 12:59:11	17	108	285	59	2405	3406	33	92.00	29	21.51	CHANGED	lhlNVGGh+FpTppsTLsph.PcohLuphhc....................hp.assspsEaFFDRsPptFcsILsaYRo...GcL+ts.phslptahcElpaatlsph...lcpC	............................................................lhlNVG.Gt.h.apTp.....h.p.T.L......sph...Pc.o..h.L.uph.hptp.....................................................ht.hc..s.p.ps..c.a.Fh..D..............R..c..st...h............FphILsa...hRs.............G.......cL.....h........h.....s.......t..p.....h.......s.....h.t....t.h........hcEhcaatlsth.........................................	0	702	944	1575
+519	PF02705	K_trans	K+_trans; 	K+ potassium transporter	Bashton M, Bateman A	anon	Pfam-B_677 (release 5.5)	Family	This is a family of K+ potassium transporters that are conserved across phyla, having both bacterial (KUP) Swiss:P30016 [3], yeast (HAK)  Swiss:P50505 [2], and plant (AtKT) Swiss:O22397 [1] sequences as members.	24.80	24.80	24.80	24.90	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	534	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.90	0.70	-6.15	84	2676	2012-10-03 01:44:59	2003-04-07 12:59:11	11	6	1808	0	887	2162	250	506.20	40	80.78	CHANGED	slsALGlVaGDIGTSPLYshpssh...............thshssstpsllGlLSLIhWoLhlllolKYlhllhRADNcGE.GGIhALhuLlp.................................................ptsptttal.......................hhhlullGuuhhhGDGlITPAISVLSAlEGLp...lhsPslp.......shllslolsILlsLFhlQphGTsplGphFGPlMllWFhsluslGlhs..lhpp.PtlLpAlNPhYAlpFlhp..psh......huahlLGuVhLslT.GuEALYADMGHFG+psIphuWhhhVhPuLlLNYhGQGAhllppP...tsh........pNPFa...thh.Pp....hhhhPhl.lLAThAslIASQAlIoGuFSlspQAlpLshhP+l+lhaTSppptGQIYlPhlNWlLhluslhlllsFpsSssLuuAYGlAVohoMllTTlLhhhhhthha.chshhhshhhsshFhhlDhsFhsANlh.KlhcGGWhPlllusllhslMhoWppG...pphlhpt.....................................htpptl.............slsphhptltp..ps.s...............................+lsGs.....AlFh...oss........pslP.slh+h.lcp.pslaccslhlolhph.shPpls.scRhplp.....pls.......ssha+lhlpaGFh-	............................................................................h.lsAlGVVYGDIGTSPLYsh+psh..................tsthshshspsslhGhlSLIFWsL..hll...solKYlhhlhR..AD.N.p...........G...........E..G..........GIhuLhuLst.................................................................................t.t.t..tptphh..........................hllhullGuuhhhG.....Dul....lTPAI.S..................VhSAlEGLc.......lssP..thp..................shl.ls.lol.l.lLshLFhlQ+aGTshVGph.Fu...P...lMllW...F...lhL...u..s...l...Glhs.....Ihtp....PpVLpA.l....NPh.aAlpFhhp....pst.....huah....s....L....G..uVh......L..........ulT.G...........uEALY..A..DhGHF.....G.....+....hsIp......l............A.Wh......h......lV...h.PsL...l.......L.NY....h....GQG..AhlLpps.....psh............pNP..FF..hhs..Ps..............hh.hhP.hl.llAs..l.A.s..l..IASQAlISGsFS..lspQAl.pLGh.lP+....h.+IhHT...Sc....pp.GQIYIPhlNWhL..hluslhl..llsFc...................s.....Ss.......pLuuAY...........G................lAVTsTMllTol.Lhs..hl...hhth......W..chshh.hs.hhhhlh.F..h.sl.-..h.saF.sAslh.K...lhpGGWlPlhluhlhhhlMhsWcpGpthhh..cp.............................................................................t..c..p..t.h...........sl..pthl.t.hpp....ps.s.....................................................RVsG.s.....uVah.....ops.........ss..lPhshhH..lpp.cslHc+slhlslhs..ssPhV...scR.hp.lc..........plu................tha+lhhpaGap-.....................................................................................................................	0	173	506	707
+520	PF01920	Prefoldin_2	KE2; 	Prefoldin subunit	Enright A, Ouzounis C, Bateman A, Finn RD	anon	Enright A	Family	This family includes prefoldin subunits that are not detected by Pfam:PF02996.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.18	0.72	-4.28	56	1643	2012-10-02 17:27:01	2003-04-07 12:59:11	15	22	498	7	1100	1563	97	102.30	18	68.87	CHANGED	QphlspapplppplppltpphpphctplpEhcpshcELphls--...ppla+hlGslhlcp.shpcspspLccct-tlptclcplcpphcplppchpchcpplpp.hhtst	.................................................t..tphpphppphptlt...pp.h.p..p...lcpph........p.c.t..c.....h......s..hc........EL...p.....l...s..s-................pp.la.chl....G.s.l.........hlcp.shp.cshpplppchctlpp.c....l.........c.plc.pphpphppphpc....hcppl.thht..t..............................	2	356	593	877
+521	PF01344	Kelch_1		Kelch motif	Bateman A	anon	[1]	Repeat	The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.	20.10	20.00	20.10	20.00	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.11	0.72	-4.41	207	19043	2012-10-05 17:30:42	2003-04-07 12:59:11	20	753	1386	88	10669	22556	644	46.00	27	22.72	CHANGED	tRsttussshssplYllGGhss..................tphhsslphacsp.....sspWpthssht	..........................Rtthusssl..s..s..p..l.Y..s.....l..G.Ghss.....................................tphh..ss..V...E.p...YDsp...............sspWp.hssh..............................................	0	3018	4230	6832
+522	PF00013	KH_1	KH-domain; KH; 	KH domain	Bateman A, Eddy SR, Finn RD	anon	Published_alignment	Domain	KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.88	0.72	-4.32	396	19558	2012-10-02 00:34:43	2003-04-07 12:59:11	24	384	4888	106	9071	18086	3141	61.70	24	16.12	CHANGED	thplhls.spt..hutlIG+sGp.sIcplpcpo.usp.Ipl.......pp....................p.hlpl.p..G.s..pslppAtp.......hl	.....................pl.ls..sph......hu..plI..G+..t......Gp..s.......I+p.....lpp...p...o..G....s....p...Ipl...............................spt........................................pt..h..lpl..s........G..s..pphptAtt...........................................................	0	2547	4378	6873
+523	PF00109	ketoacyl-synt		Beta-ketoacyl synthase, N-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Dotter	Domain	The structure of beta-ketoacyl synthase is similar to that of the  thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.  The N-terminal domain contains most of  the structures involved in dimer formation and also the active site  cysteine [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.80	0.70	-4.90	167	24208	2012-10-02 12:25:54	2003-04-07 12:59:11	21	1647	5964	191	6576	27004	6262	223.60	26	22.85	CHANGED	scslAlsGhusphPsGss.........s-phWchltpGpsuls.........phs......hsth......ssphsGpshs..t...........tFDsthFshss+ps.tMDPppRl.hLpsuhEAlEcAGl.sstph...psst...........sGVhhGssts...........sh.......tt..hhttts.......htshs..hsss......ssushuu+luat...hGhcGPuhsVsTACoSu.hsuh+hAhpslRpGcs-hAlAGGssshhsPtsh.ssasptt..hhusp...s.....s+Aasstu.........-GalhuEGhGslllpcht-A	................................................................................................................................................................lslhGh........uhh.s.h.u.s.............................ptha.p..lhtGt.s.slt.............................hs......................t.t.....h....................t...s...t......h................s.................u...............p............h..........s...........................................................th.......-.......s.............h....................t............h...........s........c................................t..h....D...s.t.....p.........ph...hl.t.s.u...h..c...A..........l.c.c................A...G.l...ss.pph.........................pssp.............sGVh.h.Gsshs..........sh....................................tt.h..hht.ttt..................hp.s.s.....hsst..........................hs.sh..h...u..u..c.l.u.hh..........hs.........l...c...G....P..s.....h...s...l.s.T....A....Co...S..S..hs...ulchA.h........p.....sl..................p...t.........G......c.....s............-........h......s..........l...u..G....G....s.p....h....h....h....s.....s.....h.......s..h.....h.....s.F.......s.....th......t....hh....ots........s..................................s+shcsts..................DG..a.sh...GE...G.sGhllLccLpcA............................................................................	1	1853	4027	5613
+524	PF02801	Ketoacyl-synt_C	ketoacyl-synt_C; 	Beta-ketoacyl synthase, C-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Dotter	Domain	The structure of beta-ketoacyl synthase is similar to that of the  thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.34	0.71	-4.26	165	23531	2012-10-02 12:25:54	2003-04-07 12:59:11	17	1627	5851	190	6174	21515	3921	108.60	35	10.85	CHANGED	hAhltGsAsspsG.tssuhssPsusuQ..tcs.....lcpALssAsls.Ps-l-hVEAHGTGT.lGDshEspAltssaGptt...........p..lhluSlKSslGHspuAAGssullKslLAlccuhlPPolphc	......................................................................hA.lhGhussp..DG.......h...p...........s........hs.....sPs.utut.......tps..........lcp..A...L....p..p.....A.....u........l....s....s.....p................p.............l.....s....a....l....p..........AHG.T......u.T.....hG...Ds..........hEspA.l.tp.s.a.Gptt...............................h..hl.u.S....s........Ko.h.GHh...u.AAGss....th.l.....tslh..u.l....c....c.s..hlPsolph..............................	0	1709	3766	5251
+525	PF00225	Kinesin	kinesin; 	Kinesin motor domain	Bateman A, Finn RD	anon	Prosite	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.08	0.70	-5.74	84	9740	2012-10-05 12:31:07	2003-04-07 12:59:11	18	241	436	149	6035	9371	509	290.90	32	34.34	CHANGED	RlRPhsspEpppsppthsph.........................................................tpttpshtssptpppsFsFDpVFss..sso........ptplapph.h.sllpssl.cGaNsolFAYG.QTGSGKTaTMtG.................................tp..GllPRslcplFpplpp.t..........................................................................................................taplp.lSalEIYNEplhDLLssp..............................ppp......Lpl+-.csp.t....shVpsLoph.Vpshp-lhpllphGppsRpsusTphNppSSRSHulaplplpppshstt.t.......................u+LsLVDLAGSERsscos.........stsp.h+EussIN+SL.sLGpVIsALsps................................psHlPYR-SKLTclLpDSLGG..su+ThMlsslSPusp......shpETlsTL+aAsRA+pl	......................................................................................................................................................................................................................................................................t....pta...t....F....D.t.l..a.s.......pss..................................Qpp.l.a.p...th........s.p.s.l....l.p...........s...s.h......p.......G.......a..N...............s...............s...l.FA.............Y.G...Q.......T..............G..................o............GK......T...a.T.M...Gs.......................................................................................pp.Gl.....l..s....p....s...........h.p...p.l.Fp...t...l...p.p...t...p...t..t....................................................................................................................................................................................................................................................p.a.plp..s...Sah.E...I.....Y......s.......E.....p.....l....h....D.L.....Lssp.......................................................................tt..........tlp.lc.-...c...s...p.....s..........hhl.t......s...l....p....p.....h..................l...p.............s......h..p..............-...hh..........p......l....h...............p.......h.....G.............p...p.....p...............R.......p...............s.............u........s...T....t...h....N..p....p................S.......S.........R.....S............Hu...l....hpl.p...lpppph..t..t..........................................................hhuclpL...V.DL.A......GS........E......Rh............t..........p.......ots...................................Gp.........p...........h.....................c.........E..............ut..........p.....I.N.p..............S.L...s.L...G....p.V..Ip..u...Lspt..............................................................................pt..a..l..P....Y.R..............sS........K....LT.............p......l...L...............p................-........S..L..............G................G.......s.............u.............+.....T.............h...........hl.ss..l......o........P.......st.........................shpET.l.sTL..c.aAp.Rs+p..............................................................................................................................................................................................................................................	0	2295	3451	4869
+526	PF00467	KOW	L24;Ribosomal_L24;	KOW motif	Bateman A, Finn RD	anon	Prosite	Family	This family has been extended to coincide with ref [1]. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.06	0.73	-7.32	0.73	-4.05	235	10200	2012-10-01 20:16:17	2003-04-07 12:59:11	24	51	5026	253	2995	5949	3093	34.10	32	20.34	CHANGED	hGchVhlhsGt.pG.ctGplhclpppp............p.Vhlc	.......G-pVpVlsG..t.......pG..pp.Gp.Vhcl..cc...............sp.Vhl........................................	0	1014	1819	2444
+527	PF01352	KRAB		KRAB box	Bateman A	anon	Bateman A	Family	The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers.  The KRAB domain is found to be involved in protein-protein interactions [2,3].  The KRAB domain is generally encoded by two exons.  The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-8.05	0.72	-4.51	69	10165	2009-01-15 18:05:59	2003-04-07 12:59:11	22	1426	46	1	4775	8709	1	40.40	54	7.64	CHANGED	VoFcDVAVsFopEEWphL-suQ+sLY+-VMLENapNLlSlG	..............lTF.cDVAVsF..opE.EWph..L-..su..Q....+sL..Y.R-.VM.L.EN.YpNLlSlG.............	0	382	388	643
+528	PF05178	Kri1	Krr1; 	KRI1-like family	Wood V, Bateman A	anon	Pfam-B_8372 (release 7.7)	Family	The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus [1].	25.20	25.20	25.40	25.40	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.66	0.72	-3.74	75	304	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	266	0	220	306	7	112.60	31	16.75	CHANGED	+cRKccE+cp........+cpElp+LKsLKhpElp-Klp+I+csuG.....tt..........................hsh...s-c-l.....-....s-FDspcaDppMpc.hFs.....-cYYsp...........................tc.cKPpa.--D.-l..t-hh......sstc..............c-	...................................+cRKcpEKpp...........+pcElc+LKsLKhcE.lp-K..LcKl+cssG......ps..............................hsl...s-c-l.........-....sDFDsscaDcpMpc.hFs..--.YYst.............................tctcKPpa..--D.-l..t-h.s.....t..........................................................................................	0	76	123	184
+529	PF02735	Ku	ku; 	Ku70/Ku80 beta-barrel domain	Bateman A	anon	Bateman A	Domain	The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the central DNA-binding beta-barrel domain. This domain is found in both the Ku70 Swiss:P12956 and Ku80 Swiss:P13010 proteins that form a DNA binding heterodimer [1].	25.00	25.00	26.10	26.00	24.30	23.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.93	0.71	-4.91	29	1701	2009-01-15 18:05:59	2003-04-07 12:59:11	11	32	1062	4	808	1704	49	191.60	20	42.31	CHANGED	lplG.....tlslsVpl..ashspppthhhhhhhtcc.........p.spscpcplstpssp.............................tlp...ts-hh+ua......hhsschlslsc--lcplp.hss.......tslclluFhshs..lhchhahcsuhalhPccpts....tpsassLh..cshhcppphAls+ash+s...p.plssLhPpt....................................................puhhlhpLsas--lR.shshhthtsstt.......sppplchh	...................................................................................................................phu.....hlslsVph....asss.p.p.p.p.h.......h.h..hhtpp.........................hshhc..hp..ph...s.p.ps.sp................................................................................pVp...tc-.lsKuY......hhs.s.c.....h..Vh......lsc--l..p.p.lt..tss...............................pslclluFls..ts..t...........l......h.h.hh....c..c.s.h..a.l...h.Psp..p...ss..........................................................c.s.as..hLh..cultcps+.l........Als+h..sh+p.......+.p.lssLhPtt............................................................................pslhlhpL.as--lR...sh.s...h.h..t.......................h.....................................................................	0	264	480	665
+530	PF03730	Ku_C		Ku70/Ku80 C-terminal arm	Bateman A	anon	Bateman A	Family	The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C terminal arm. This alpha helical region embraces the beta-barrel domain Pfam:PF02735 of the opposite subunit [1].	21.20	21.20	21.60	21.40	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.21	0.72	-3.46	18	467	2009-09-10 20:09:42	2003-04-07 12:59:11	9	16	255	7	249	454	0	93.20	21	14.94	CHANGED	lc.saposphtNP.LQpaapsLpslALchpEsh.slDtplschpphpc..+hssh..lsch+phhh.s-h....p.-spsutcpppcs..Eus.....suKKsKh-h	..................................tapssph.NPsLQpaa.p.....sLpshAL.....c.....p.....t...P......ts.....D....slsc..hpphs.c....chssh.........lp.......ch.+ph..h.....pph........p.ctt.htt.cp..t..t...tp...t...........hp...........................................................	0	75	127	191
+531	PF03731	Ku_N		Ku70/Ku80 N-terminal alpha/beta domain	Bateman A	anon	Bateman A	Domain	The Ku heterodimer (composed of Ku70 Swiss:P12956 and Ku80 Swiss:P13010) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the amino terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface.  The domain comprises a six stranded beta sheet of the Rossman fold [1].	20.60	20.60	20.70	21.00	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.24	0.70	-4.92	17	702	2012-10-10 16:07:06	2003-04-07 12:59:11	10	19	300	4	399	710	4	208.10	18	32.63	CHANGED	ullallDsu.sMhps.pspps.......hp.shpshpphhtp+lhsps+.DhlullhauT-pscN.....sssapNlhl.........lp.....clshsshcplpclpphhps............tsstpsshhsuLhsshsl...hpc..spt+hs+++lhlhTs.csPh.......stsphchhhtc.................upDhpppthphs..hhhL......stt...phhap-.hp.utcp.pthhhs.pt........phpchhpplpshpphcRth	........................................................hlhhlDsu.sM....hp..........sttp................h...p.sh.ps..ltph.hppplhss....s+...Dh..lul..lhas.T......c...........p.......o......c.............s.............................sts..........a.p.plh.l.......................................hp.......pls.s.s.hctlpclpph..hps...................................s.....s..p..p..s.s.....hh.ss.L....h.ss.h.p.h.......h.p.p.........t........t...t..p....h.tp++.l.hl.hTstcsPh..........spsphp.t.hhpc............................................st-lpp.s..h.thp..hh.l...................t..p.p.h.hp.....-........p.......s...t...........t..................................................................................................................................................................................................	1	128	216	324
+532	PF00014	Kunitz_BPTI		Kunitz/Bovine pancreatic trypsin inhibitor domain	Fenech M	anon	Prosite	Domain	Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich  alpha+beta fold. BPTI (bovine pancreatic trypsin  inhibitor) is an extensively studied model structure. Certain family members are similar to the tick  anticoagulant peptide (TAP, Swiss:P17726). This is a  highly selective inhibitor of factor Xa in the blood  coagulation pathways [1]. TAP molecules are highly  dipolar [2], and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha  helix [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.26	0.72	-3.76	147	4915	2012-10-02 12:37:03	2003-04-07 12:59:11	18	353	273	213	2635	4772	22	53.40	35	18.48	CHANGED	hCphsh.ssG..s.Cp...u......th....+aaas....spsppCp.pFhYuGCtGN..t.....NsFpohc-CpphCt	...................................C.hsh...p....tG.....s...Cp.....s..................hh........Ra..a...as............s.ps...ppCp...pF..h.Y...u.................G.C...t....G...N...t.......NsFtopcp....CpptC................	1	878	1112	2046
+533	PF03521	Kv2channel	Kv21channel; 	Kv2 voltage-gated K+ channel	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	42.50	29.90	18.40	19.70	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.92	0.70	-4.93	4	108	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	39	0	63	94	0	204.20	45	32.14	CHANGED	KosEous+KDKspDNHLSPSRWKWs+RsLSETSSNKSF-sK.QtsspK.......spSSSSPQHLssQpLE-lYNchsKTQSpP.lNopp.sQsu+P...tEElEMpplssPps.LsssppEullDMRShSSIDSFhSCATDFsEopR.shoPhuu..hphphss..ss.cta.tupst.hLs.pttpusAs+-uhpEhtststshp.-sts...h..s..pus.hlESP+oSlKssNPL+.RSLKVNFh-ucsso..ssssshps.Plp.tsashtusttlsThhL.-p	.................Kss-s.spK-psp.DNHLSPs+WKW.s.++.shSETSSsKSa-sK.QtsspK.................sp.oSS.....S.......P.......QHLssQpLE.hYNchsKT.Qsps...Nscp.pt.t.t+P...cEElEM-plssP.t.Ls..s.psEsl.lDM+Sh..SSIDSFhSCATDFsEspR.shsP.su.................................s.pttt..ssp..sh.th.s..s.sh..ps..ss............s.h.-SP+SShKssNPLK.RuLKVNFh-s.c.ss...ss...hh.....s.....hs....s...........................................................................................................................	0	2	8	24
+535	PF02828	L27		L27 domain	SMART	anon	Alignment kindly provided by SMART	Family	The L27 domain is found in receptor targeting proteins Lin-2 and Lin-7.	20.20	20.20	20.40	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.41	0.72	-4.28	20	1179	2009-01-15 18:05:59	2003-04-07 12:59:11	11	37	100	20	527	978	0	53.10	24	14.32	CHANGED	slppsh-lL-cLps.ssss.....pchppLpplLpstahpullcla-pltppshssssss	........................hphsh-lLccLps..spst.....p-hptLpplLppsahp..u......L......l.csH-pltppphtss............	0	84	132	273
+536	PF02448	L71		L71 family	Bateman A	anon	Pfam-B_1976 (release 5.4)	Family	This family of insect proteins are each about 100 amino acids long and have 6 conserved cysteine residues. They all have a predicted signal peptide and are probably excreted. The function of the proteins is unknown [1].	25.00	25.00	32.90	29.30	18.80	18.20	hmmbuild  --amino -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.18	0.72	-4.14	10	105	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	12	0	35	105	0	71.40	36	65.23	CHANGED	p.CccltcpCpcshpRLssssD.slchFNcpCRccsc..hpWRsVoRCELp+lsClh...cspshsCcNlA........chssh	...CccltcpCppshpR...LssssD...slshhNppCRccst..hpWRsloRCELpphsChh...cscphsCpslAchh............	0	10	10	23
+537	PF00753	Lactamase_B	lactamase_B; 	Metallo-beta-lactamase superfamily	Ponting CP, Bateman A	anon	[1]	Domain	\N	22.70	21.90	22.70	21.90	22.60	21.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.20	0.71	-4.65	305	34807	2012-10-02 15:46:01	2003-04-07 12:59:11	22	191	5226	350	10222	34846	12115	193.00	14	50.57	CHANGED	hsthsssshllt........ss.spsl..llDsGhststtthh..............................hthpstplctll..lTHtHhDHhGuhttltpthshshhhttttttthhtthh.............................................................hhhttttththtththhhhts.stsssshhhhh.....ttppllhsGDhhh......stsththth...........................................................h.....................h.....hh..uH	...................................................................................h....ttsshllt...........ts..pph.l.....l..lDsGhshsthpth...........................................................hthp.s..t.p..l...p....t....l....l.......lT.........H.t.H...........h.........DH.....h.........G......u.........l........s......t......l.....h.......p........p......h......s.....h......s......h....h...h...s...t....t.t...t..t.h..h..ht...t.h...........................................................................................................................h..ht.p.t.t..t.h..t.h..t..t...h....t..h..h....h....h...s.....t...s.........s..........s.......s........s...t..........h..h.hhh..............................stt....p.....h....l..h..s.GD..hhh..............ttshhhh...................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	3453	6690	8675
+538	PF02652	Lactate_perm		L-lactate permease	Mian N, Bateman A	anon	COG1620	Family	L-lactate permease is an integral membrane protein probably involved in L-lactate transport [1].	19.70	19.70	19.70	19.80	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	522	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.72	0.70	-6.01	8	3338	2012-10-02 15:12:49	2003-04-07 12:59:11	9	5	2259	0	540	2191	157	490.80	36	95.93	CHANGED	LSALlALsPIlLFhhuLslhKhKGYhAuhlolAlolhIAlhha+MPlphshuSslhGhlhGLWPIuaIIluAlFLYKlSVKoGtF-II+pSlhuIosD+RlQllLIGFsFGuFLEGAAGFGsPlAIoAAlLVGLGFpPLaAAuLCLIsNTAPVAFGAVGIPIhusuusssls......................shEISphlGhhLshhollIPFalVhlhsG.a+GIK-saPAllluGhSFAlsQaLoSshLGPELPsIluuLlSLsshslFLKh.WpPKpla+.ssptpotsspst..........+hscllcAWoPFlLLossIllWs.PhFKAlap...psuhlhhssh.h.h..lsp....hlhphsPlss..puhshssVaKhcLlhssGTuIllAsllS.hhlh+lsspDshslFspTLKEhtlPIloIshVluFAhlsNaSG........MSsoLAluLAc.TGpsFTFFSPhlGWlGVFlTGSDTSSNlLFGuLQhhsApplGlsssLlLAANTsGGssGKMISPQSIAIACAAVGLsGKES-LF+hTltaSLIaslIsullshll	............................................................................hSuLlAh.lPI..lhhhlsLs...........h........h........+...........hK...........u...h...h.A.u.h.h.o.ls..lsl.l..l..Alh....h..........a........c.....M...........P.......s.........s.....h...u.......h...u.us.s.Ghh....hG........la...PIuaIllsAlalY+lolcoGpF-lI+so.l.h.u.I..o..s..D.p.R.lQhLlIuF.sFGu..FLEGAAGFG..sPlAIsAslL.luLG.FpPLhA.......Ahl.sLIuNo.APVAFGAlGlPl..hss...u..p...s....s...u...ls.................................s.h.p..luth...s...u..h.p...L...s....hhsl.l.l.PF..h...l.l....h....l....h.......s..........G.........a............+G...........l............+.......E............s.......a.......P.sh...l.....luGh...oFuls.Qal...su..s..a....l...G...PEL...ssIl...uu..L.lol..h...sl.s.l..a...hKh....a...p....P...c....p....h....h..c...h......t.....s...t.....t....t...t..t...s...p.hsh.....................................................shtpl..l...pA....WsPal.lLss..h..l.h.l.hs.h.......h...K..s..lhs........................s.hl..........h..h...t...........lpt.....h.hphs.sl.su.................h..s.....h.shphshl.u.....ssGTsIl.l.u.s...l...lo....hh.........h.........h.........+...........h.........p.........hp..p........s........hp.s........a..spT............l+pl.thsllo....IshllAhA..hlhs..a.SG............................h.ossl.u.h.u.lAp..s.G..s.hFshh.S.....PhL.GWlGs.FlTGSsTuSNsLFusLQt.s.sA.p..p....l......G......l............u.............s........s........L........ll.AA.N.osGGs.sGKMISPQSIAlA.sA.A.l.....uh.s...G+..E.....u.....c.....lh+h..T..lp..a..S...l...h...ah.hllullshl............................................................	1	182	344	454
+539	PF03798	TRAM_LAG1_CLN8	LAG1;	TLC domain	Bateman A, Finn RD	anon	Pfam-B_1398 (release 7.0)	Domain	\N	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.84	0.71	-11.57	0.71	-4.76	168	2246	2009-09-11 23:05:38	2003-04-07 12:59:11	11	31	362	0	1453	2051	32	191.70	17	58.71	CHANGED	casppshshlahhhsshhuh....hlhhpps...........................thht.h..........phhh....s....thh.hhhhphuYalhs..lhhhhh.pttpt...........................................................................h.hlhHHl.hslhlhshuhh..................................hshtph..shslhllh-hoshhLphs.......phhphh.th....................pt.............h.hhh...hhahls.FhhsRlh.....hhshh.....hhhshhthh...h.................................................................hhhhhhhhshhhs.L...pllplaWhhhllc	....................................................................................patpphhphhahhh.shhhuh.....hlh.hpps...............................................hh..h.............st..h...t...........h....p.hhhhhphuaa..htp....lhhh.h.h...chtcp..............-h...................................................................................................h.hlhHHl..hslhh.ls.huhh.....................................hsh.hph...s.sh.l.hh.l.t...-.ho.....shhLp.hs.......c.hhphh.th................................pt...............t.hhh......hl.hhhs.ahh.sRlh...........hhshh..........hhhs.h.h..h............h................................................................h.h.h...hh.h.hshh.hh...L.....hlplhWhhhlh..........................................................................	0	465	733	1095
+540	PF03161	LAGLIDADG_2		LAGLIDADG DNA endonuclease family	Mifsud W	anon	Pfam-B_3225 (release 6.5)	Family	This is a family of site-specific DNA endonucleases encoded by DNA mobile elements. Similar to Pfam:PF00961, the members of this family are also LAGLIDADG endonucleases.	25.00	25.00	25.30	25.10	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.90	0.71	-4.36	18	250	2012-10-03 01:41:40	2003-04-07 12:59:11	8	26	160	6	57	270	38	167.00	22	52.22	CHANGED	.hpllhGhLLGDualcpcs..pspp.......hphphphpp......tah.+hhhhhp..tasssss..hppphs..............ppGchhhshphpThsh.ssFshltphFYh...sspK....hhlPshlpp..aLTPpuLAaWhMDDG......p........sspulhlsTpuFohc-lphLhcsLpp+asLcsol+psp.......spahIal.spohthah	..............................................................hpllhG.LLGDup..lptps....ps..pp.......................hthp.phpp.........htah...a.h.h.hhp....thsp.p.....ht.ptht.....................s.p.htshpF..pThsh.spFshh.tchFY..........sstK...................hlP..p..p..l..tp..hLT.PhuLAhWhMDDG.........................ttsts.....lhlsTpsFo.hp-.h.hLhp...hLpppas....l.p.spl...pppt............tthhlhl.tpsh..h.................................	0	23	45	52
+541	PF04916	Phospholip_B	Laminin_A; 	Phospholipase B	Finn RD, Mistry J, Wood V	anon	Pfam-B_5721 (release 7.6)	Family	Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids.  This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast [1].  In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina [2].	21.30	21.30	25.10	23.50	18.50	20.60	hmmbuild  -o /dev/null HMM SEED	553	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.76	0.70	-6.39	6	390	2012-10-03 21:14:07	2003-04-07 12:59:11	8	9	163	6	279	416	25	411.50	27	85.60	CHANGED	p.hph..ullhhl.http..pshsss.....ppspsslshst.shp.................sth.stst......lAhupapssVNpTGWuhLEl-stp...shssplQuYuAGhLEGhLTtthlhhHhp.NohpshCcN...tspaCscLt-ahspN.+Whcppl.....pps.sD.aWpQlshslsQLsGLhsGYppRs.pscIshc....hasIhhhNhsGDlhDLt.........pphs+TcsPs........Fchs..G+CSA..LlKllPssc.......laFuHsThSSausMLRlhKpYcFs.......c.phsPGphloFSSYPGlLtSoDDFh.lpoutLsllETTlu..saNtpLh+phsP.spVhsWlRuhlANhlApsuppWsphFSRaN.SGTYNNQWhVLDh.Kp.hcspcpL..........sc..ssll...................allEQhPG.....hlsppDhTt..hLp+.oYWsSYNlPaaKplhclSGh....phscchG.aasastsPRA+IFcRDcusVTDlsShptLMRYNsYpc...-.hu+Cc..............CsP.PYoAchuIusRuDLNssuG............ThEh..u..GhssHuu.......lDsKs......sshcLh.......pphphhAh....uGP...shcslPsFcWsc.sshc-tssHhGpPDhWNFshVshK...........Wph	.................................................................................................................................h.................................................................................................h....t.h......GWs.lplts....................hs...s....hh..suGhhEu.....ho....h...h...N..h.h.....t.....h.t...........................th...t.l.pahttp.....tahppph......................t.....ps...aWtphthh.h...Q.hpGl.tuhtt......................t............................h.....hhp..uDl..D...l............................................h.t.....t........................h......sp..CSu..ll...+lh.ss.p..............plhhuHs.oWtsY.ts.hhRlh.Kpa.p..h.th.........................h...upphsaSoYP.Ghl.ShDDFY...l....h...s........s.........sLhhh.pTT..s...shN.t.L..h..p....l....p..s....t.slhtahRsh.............hAshhAps...u.tpWscha.t.phN..S..GTYNNQWh......llDhptht.......t...t.......................................thl..........................................................................................hlhEQhPs.......hh...tD.Tt.....L....p..sYasSaNhP.a.a.pl.hp..huGh.....................t.ph.u................h...pap....ssRu.IFtRsts..tl.......ts.hpshhthhRhNs.a.p...D.hu....tp.................s........IssR.....DL..ts....t.........................................................s..su...........hDsKh........ss.hthh................................tt.ht.hhsh....sGP....s...t...t.....ssFpW.....t..h.......+.G.Pp.apF..h......h................................................................................	0	154	189	239
+542	PF04031	Las1		Las1-like 	Wood V, Finn RD	anon	Pfam-B_10636 (release 7.3);	Family	Las1 is an essential nuclear protein involved in cell  morphogenesis and cell surface growth [1].	22.70	22.70	25.60	25.40	19.40	20.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.97	0.71	-4.56	26	316	2009-09-11 09:56:21	2003-04-07 12:59:11	8	8	274	0	222	321	1	147.90	32	29.95	CHANGED	slsW..tshpEhpplhphla..............sp........................................................s.sppccAlp+lp.sWpsRu.....plPtsl-uTuhLlpshLtD..............................................ssthsstslc...htYuhAllR.....FVNsllDstQp..uphshshpplApplGlPphhV-LRHtsTHcp.LPsLshLRhusppsLpWLacpYWppp	..................................ssWhshsEh.pVpphha..............sp.......................................................................................s.ptpppAlpplp..sWctRs........plP..hsV-uTA.LlpshLtD...................................................sst.hsp....tlp...hhYuhAl.sR.........FVNtls-t..hpt.....p...t...ht...h.shtplApp..lGl..Ps..hhV-LRHpsTHcp.LPuLshLRpusphsLpWLhcp...YWpp.............................................................	0	80	125	183
+543	PF00057	Ldl_recept_a	ldl_recept_a;	Low-density lipoprotein receptor domain class A	Sonnhammer ELL	anon	Swissprot_feature_table	Repeat	\N	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.59	0.72	-4.05	53	19728	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1237	198	54	11586	17417	67	38.20	41	15.75	CHANGED	ssCp.....sscFpCssup.....CIst.pahC...DGpsDCp.....DGSDE....psC	.............................h.tCt.......ssp.F.p..C......s...s.up.............C.....I...st...p..hhC....D..G..p..s.DCs........D..s..S..DE......tsC...............	0	3071	3990	7792
+544	PF02987	LEA_4	LEA; 	Late embryogenesis abundant protein	Griffiths-Jones SR	anon	Pfam-B_106 (release 6.4)	Family	Different types of LEA proteins are expressed at different  stages of late embryogenesis in higher plant seed embryos  and under conditions of dehydration stress.  The function of  these proteins is unknown.	36.00	10.00	36.00	10.00	35.90	9.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.72	0.72	-4.09	26	1180	2010-01-13 15:33:07	2003-04-07 12:59:11	11	27	134	0	431	1127	2	40.60	29	59.19	CHANGED	cDhsu-KAtEAKDsThcKsGEhKDass-KAtEuKDpss-KstEh	........................stpKAt-..s..t.......-ss...t...c....Ku.......u-.......s.......pDts....t-K....As-..sK-...tst...pth............................	0	117	228	375
+546	PF04004	Leo1		Leo1-like protein	Wood V, Bateman A	anon	Pfam-B_11226 (release 7.3)	Family	Members of this family are part of the Paf1/RNA polymerase II complex [1,2]. The Paf1 complex probably functions during the elongation phase of transcription [1]. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors [3].	20.10	20.10	20.70	23.30	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.34	0.71	-4.55	86	331	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	272	0	230	324	0	165.30	31	32.43	CHANGED	hahh+lPsF......ls.l-s..............cPFcPcoa.ts.p....................pt......................hpphh.php...NolRWRhsp..s........psGp...........tpSNA+lV+WSDGShoLplGs...Eh.aDl.......................................tppsh.tp.t........saLhsppst.........................................sllp..sputlspphshpPsoh....sStsH+..............phstulsp+ptpcstt....hhhtsspDPEhc+cctp+	.........................................ahl+lPNF......Lu.l-s..............cPFDPpsa.ts.t.p..............p..hscp.......................................................................ttp+hhhcsp...NolRWRhsp....s..........tpGp.h.........pcSNARlV+WSDGS..hoLplGs...E.h.aDl..................................................hptsh..p.sp............saLhlpps..........................................sh.Lp....s..p..uhhppplshp.Pp.os........sStsH+.......pho.hulssRstKppt.....thhh.sspDPEhp+pph.....................................	2	73	122	188
+547	PF00060	Lig_chan	lig_chan; 	Ligand-gated ion channel	Bateman A, Sonnhammer ELL	anon	Blastp NMZ1_HUMAN	Family	This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null --hand HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.03	0.71	-4.49	44	3260	2012-10-03 11:11:44	2003-04-07 12:59:11	21	78	277	465	1868	3242	57	253.80	21	33.83	CHANGED	oh-lWlslhhsalhluhslallt+.hoP.h-apt.........................................................................spaolhsuhWFshushht.pGsc...pP+uhouRllsslWahFsLllluSYTANLAAFLTlpchpss.IpuhcDLtpps.plpassht.uoohthappop.........hpphaphhpstps..........................ph.spssp-Glpclcpu..th.hAalhEsshl-ahsscp.......CchhplGp..shsspGaGIAhstsSPhpsplohAILpLpEsGclpplcsKWappp......pCsspsst..........sssspLslpshuGlFllLshGh	................................................................................................................................t..plW...h.h..l.hhs.h...l.h...l......u.h...l...la.l...l...t..........+....hss.hpapt.................................................................................................................tsph....s.l...h....s..u..h..W....a....s..h.u...s....h.h...............p.....p.....u.sp........hs..P.....+..u.....h.o..s.R.lls..............s.............l.Whh.F.s.......l.I...l..........luSY.TANLAA.a.LT...l...p....c.h...t...s.s...I..p..u..h.cDLtpps.hthhshtshsph.hhpppp.thhphhh.hh.ttt.t.hhtttttsh.thh...hhhh....................................................................................................................pp.pp.hh.hsth..tthhhhh...ts.ht.h.hhhhh..ptt.h.phhpchhhtts..tC.tptt...........tsstLslps.htGl..Fhllhhu............................................................................................................................................................................................................................................................................................	0	597	867	1417
+548	PF02900	LigB		Catalytic LigB subunit of aromatic ring-opening dioxygenase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	19.80	19.80	19.90	19.80	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.68	0.70	-5.41	47	3175	2012-10-01 19:17:44	2003-04-07 12:59:11	13	7	1832	5	918	2499	472	260.20	23	90.78	CHANGED	sshhhSHssshhhh.s.....sttph..t...ph......................ht.htppltp..h.............cP-slllhuscahs....phhss.hlssss................psltD........ah.......h.phphshsGss-LApplschlhtssls............spphslDHGshsPLphhhs..........shPll.lslss.....hhsspcphplGcultphht.....scpVlllGSGuloHplts.phs.............................................hstcaDchhlchlps....s...chptlhshpppt.ttttups.stchhshhhshGAhs...............phhsphhtatslsths..sshs	..............................................................................................shhluHu.s.sh..shps.........st.pt...........th..........................................h.th.t.pplst...................cPcsIll..h..........osH...Whs........phh.s..ls.s...ss.p...................................ps.laD.........as......th..P.t..h...hch..p..Ys.hsGsPpLAp..pls.ch...l.tt..s...s.lshth..............................p.shsl.D..HGs...h..sP.....Lhhh.hs...........................chc.lPl.l...p..lu......lss...........hhsstpphc...lGcslttht...........-csVhlluSG.s.ls.H..s.l...t....s......p.hstts.............................................................hs.tpFD.phlhphlpp....................s......ch.c...t.L...s...sh...h.p.......p..t..s..s.t...h..u...p...s...s...cchhshlhshGAhss.....................hphhs..chh.htshs.h.h.h......................................................................	0	265	556	770
+549	PF03893	Lipase3_N		Lipase 3 N-terminal region	Birney E	anon	Birney E	Domain	N terminal region to Pfam:PF01764, found on a subset of Lipase 3 containing proteins. 	21.10	21.10	21.10	21.50	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.44	0.72	-4.16	10	181	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	56	33	114	168	0	71.60	22	15.93	CHANGED	hlsslhslusupWuhph..............pcssaots-shspWspusssp...apshspss+shtsVasss....L+sPcltsshsshth	...............................h.hpth.shusApWs.t................plpaohtcshsp..WshussAth..a.s.hsphsphshslhpss....hpsPthts..t....t..........................	0	14	65	97
+550	PF01764	Lipase_3		Lipase (class 3)	Bashton M, Bateman A	anon	Pfam-B_893 (release 4.2)	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.84	0.71	-4.57	61	3914	2012-10-03 11:45:05	2003-04-07 12:59:11	20	76	1209	69	2118	4488	506	139.30	18	28.90	CHANGED	lluaRGTp..shtpahssh.phshsshp.h..............................ssplcpGFhcsap...................................thhpplhsplpc.Llpphs......s..hplhlTGHSLGGulAsLsAh.........lhppt............tplplhoaGsPRl...Gshsauphhs.................t...........hhRllpppDlVP+lPshhh	...............................................................................................................lsh+Go............s..ph....h.....s.h......h............h.........................................................................................tshsc.t.Gh.h..p..h.hp......................................................................................................h...h...p...p..l...h..p..t...l...pp.....hh.....p.phs.....................p..hplh..l..o..G.......HSL.....GGul...As..lhuh........................................h.h.t.ph...........................................hp.s.hs..F..u.s..P.t.l........s..s.....t.h.t..p.hh.p......................................................................hh.p.h.s...t........t..D.lshh....hh.............................................................................................................	0	783	1383	1855
+551	PF04571	Lipin_N	lipin_N; 	lipin, N-terminal conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4929 (release 7.5)	Family	Mutations in the lipin gene lead to fatty liver dystrophy in mice.  The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserved region is found at the N-terminus of the member proteins [1,2].	25.00	25.00	25.90	25.20	23.70	24.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.55	0.72	-4.41	10	549	2009-09-11 22:04:36	2003-04-07 12:59:11	9	10	268	0	306	483	2	107.30	51	13.02	CHANGED	MsYV...uuplasoVpclYsuINPATLSGAIDVIVVEQpDGoapCSPFHVRFGKh.GVL+ss-KhV-IplNGp.sDlpMKLuDoGEAFFVcEs.--p.pclPshLsTSPlsssssu	....................MsYV....tplhsoVpc.h.ap...ulNsAT..L.SGsIDVIVVc.......Q.............D..G......o.......hpCSPFHVRFG..Kh..GVLRucE..K...l......V..-IclNG.....ps..l..D.l...pMKLG.-sGEAFFVpE.s....-.s.p........p....lPt.LtTSPl.s...s.....................................................	0	91	150	231
+552	PF03180	Lipoprotein_9		NLPA lipoprotein	Mifsud W	anon	Pfam-B_1418 (release 6.5)	Family	This family of bacterial lipoproteins contains several antigenic members, that may be involved in bacterial virulence. Their precise function is unknown. However they are probably distantly related to Pfam:PF00497 which are solute binding proteins.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.38	0.70	-5.46	35	6507	2012-10-03 15:33:52	2003-04-07 12:59:11	9	8	3244	23	955	4106	60	229.70	38	86.36	CHANGED	lplGshssscu-lhc..hlpphhKccs.lclclhpFoDYspPNpALscG-lDANhFQHhPYLcphs+s..pttpLVslussalpPlulYS........+KhKsls-L...cGusIAlPNDsoNpuRALhLLppsGLI+LKss.tshhAThpDIs-N.PKsLcl+..El-AutLPRsL-s..VDhAlINssYA.lpAsLsPpcDulhhE.s+.s..uPYsNllVsRp...ssccsstlKcllcAhp.oc-V+phlpcp...a.sGuslPua	............................lplGss..s.s..s..c..s..p..lhc.....hsp..p..h.h.c.c...c..G....lclclhpF.s.D.YshPNpALscG-lDANhF..Q.H...h...P.aL..-p..scc.....+.....Ghc......L..s.s..l..u.s..s.al......P...hu.l.Y...S..................+K...h..K..slc-l......c..Gu..p......l..AlPN.D.soNtuRAL..h.L..Lp.psGLI+L....K....ss....s....s......h....h......u..T....s..t...DI...s-....N....PK....pLKhh...El-.AuQlsR....sLsD....VDhA..l.I..N.s.saA...hp...u...G.L.s..P..t..c............Du.lhh.E.......sp...s..........s..P..Y....s.Nl.l.....ssRp.......sscc.s.pt....lKc.llcs.ap.Sc-Vpchlpcp...a.pGuslss...................................................................................................................	1	211	490	731
+553	PF02190	LON		ATP-dependent protease La (LON) domain	SMART	anon	Alignment kindly provided by SMART	Family	This domain has been shown to be part of the PUA superfamily [1].	21.90	21.90	21.90	22.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.53	0.71	-4.65	158	5691	2012-10-02 17:37:24	2003-04-07 12:59:11	11	68	3513	13	2086	4772	4482	199.10	23	30.32	CHANGED	plPllPLtshl.l.aPshhhslp.lt..csp............hp......hlcpsh.......................pp.st...h...lhlh.....................................................ptp........s.......t.ssl..................................................aplGsl.....upIhp.h.....................phs..c..Gp..................................................hplllp..Ghp.Rh+l....pph................................................................................ppsa....h...............huclp.h..........................................ptptpptt.......ptltph...hpp..................................hhp.h................................................phhpth.s.phh.t.hpshppssp.Lsshl...ush.ls....hshpc+Qp.lLcthsspcRlptlhphLpp	.......................................................................................lPllPL...cshl...l...aPthh...lPLh..ls....ct+s..........................lp.h.lcpsh...............................................pp..s..pt......lhls...............................................................spp.ps...t.p..ts.........s.h.s..cl...............................................................................................................................a.plGsl...upIhp.hh................cls......D...Gs..........................................................................lplllp...Ghp.R..h+l.........tph........................................................................................................................................................................t.pcsa..h.................................................tAcl..p.hl............................................................................tttppt.t..........ptl.tth...h.t.p....................................................................................................................................................hhpth.............................................................................ph..p.ph.....s........c....h....h.t..s....h.p....s..h..s.c..ss....p..L...u...Dhl.......Aut..hs.........lph....p.c.+...Qp.lL....Eh.sl.....pcRLchlhthh..t..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	700	1277	1725
+554	PF00560	LRR_1	LRR; 	Leucine Rich Repeat	Bateman A	anon	Reference 1	Repeat	CAUTION: This Pfam may not find all Leucine Rich Repeats in a protein.  Leucine Rich Repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations.  These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.	20.60	9.30	20.60	9.30	20.50	9.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.84	0.76	-7.83	0.76	-3.07	2414	25597	2012-10-02 21:32:02	2003-04-07 12:59:11	28	4912	1389	82	13545	96601	2712	23.30	33	5.68	CHANGED	pLppLslss..N..plp.p................lst...htph	.....................pLphLcLSs.N..pLs.p................................lPs.p..ht......................................................	0	2975	8467	11049
+555	PF01463	LRRCT		Leucine rich repeat C-terminal domain	Bateman A	anon	SMART	Family	Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.	20.00	4.20	20.00	4.20	19.90	4.10	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.26	0.74	-7.54	0.74	-3.10	59	1112	2009-09-10 23:15:08	2003-04-07 12:59:11	19	248	79	18	530	955	2	25.80	34	6.10	CHANGED	shhCssPsthps..lhphs......phsCs	....sRCsuPtpL+shpltplp.....pcFpCp.....................	0	82	113	266
+556	PF04180	LTV		Low temperature viability protein 	Wood V, Finn RD, Mistry J	anon	Pfam-B_15065 (release 7.3);	Family	The low-temperature viability protein LTV1 is involved in ribosome  biogenesis 40S subunit production [1].	25.00	25.00	26.50	26.60	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.55	0.70	-4.97	4	274	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	231	0	202	269	2	368.80	26	86.00	CHANGED	sKKpAppFpLVHRsQcDP.haDEsAsp+VLlPspp.N..Kou...shpspDtp.s...shRspcGEAApYGlaFDDoEYDYhQHL+slGpssusulhlsupshspp.cpK......ctpc.h.hpspspcL..p-shhsphphph....shtsQQs......sPDtIuGFpPDMDPcL.......REVLEALEcpuhshND-E.s.--...........DucEhc-hDhp.........tthDEh-D.ut..s.p..cs.cc..a..s-E.sch..h-hspsupshshps-hpht.cca...chhpK+psDst.usus.u-hpsS.ppDs......l.-h.po..pKu+s+pKtuAhoshSshSMSSSALsRoEsholLDspa-clcEc.........Ysshh--hp.lc....................Qs....sVhsc....tppF-sMhD-FLssatsp......sRphucp+hcpp+hKpul-ElcchR+s.t+ARh	.............................................................................pKKpAhpapLVHRuQpDPLht.DpsAsp+VLh......s..s.....................................................................t.................p...t.p.....................t...t.pcuEttpYGlaa.....DD..c.YDYhQHL+...........t....p.sss....s.hlt.sts.....ttp....ctc...............................ph.c..............t......t..........p......l.............ss...s......h.h.Sp.hppth...........shts...s.........sPD.lAuhps.D..h....D...c..............c..lLpA..cspsh....t.t....-..p.t.....pp..........................csp.Ehp..-...-.....t.............................t........t....p.-..p.p.t..........p.t................tt.....t..p.....a............c.-...s..p.........t........hp..........s.s..ss.s..h...p.h....s.tp.hh..h..pcF................c+.....c......p.h...s.............t...h.........u..sh.s.....s.....c....h.p.s.............p.........t...........s...s..................h.......ph..t...............pttc.....pp...h....+....h......ssh.ps............p.....s..........h.......s.hs..sst.h..cs...Et...ph.....l.ssph-..php.pt.........................Y.sp............p...c..p..p.....t.................................ps..s.sh.st.......tp...p...hpp.h.......pt.....ss.....p......................R.hsc..p.p..t.cp.tt.h.ppuhcp...pc.+t..t.sp.............................................................................................................................................................................	0	68	104	163
+557	PF02123	RdRP_4		Viral RNA-directed RNA-polymerase	Mian N, Bateman A	anon	IPR001795 & Pfam-B_6212 (release 8.0) & Pfam-B_9867 (release 8.0)	Family	This family includes RNA-dependent RNA polymerase proteins  (RdRPs) from Luteovirus, Totivirus and Rotavirus.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.79	0.70	-5.78	28	1146	2012-10-02 12:54:00	2003-04-07 12:59:11	11	8	405	10	1	4591	0	427.20	31	60.01	CHANGED	sphhstspphhtphhshpttstsst+sslp.tplhtsthpphsps.........sth..shhphhh..............................................................ps.h.shh..............hh.......................................h.......ht...............................................tss.p.sshhsphpsl.G+hssshc.......hptEhpp+sssslsh.thsptspctl.......hshltplhppcl.................................p.h.tp.....ttt..............pthhpsc..hh..tsschs++sls-s......lchh.sptcscst........h..tpKl.Ep................................G.+sRhIh....usshlsalshchlhtstcc.........th.supshlshssttphhshtpcl.............hpttt.hhhhDhosFs.SpHshcshptlh....p.hpppls.shshttt..........h.h..hhpshtshhlhlsss..htp..........chhGslhSGp+sTohhNSllNhshhphshuthshsh.........ps.GDDslhuhpss..............hhcphpphsh+spshKpshu..tuE........FhRht..............hpptshtu..a....................lh..RssushloGsW	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...h.h.s....ph...............php.c.s.shs..th.t..tp............h..l.thh.p.l..............................................................................p.h.psp........h........s.phscphLt-s..................lph...sttpsc.p...................tK...c..............................................................................................G..+hRlIh......ph.lsp...phl....h.chhh...tpc.............h...t.p...hhs.........s..s.......t..p..h..........t.l......................h..hDhotas.S...p....sh....cch.....................lps.hh...s........s..ps..psh.........................p.Lh.t.t.h..hs....l....h.......sS...h.l....p..lsD.Gs..lltp....................................h....GshtSGphpTpusNSh.h.....p.....l...h...h....h...h.........t.....s.....h..........u.....p......h.....u...th........................................GDDshtshp...s..................hthYtp.h.s.hK..scs.............................................................t...thh....a.........................p.....................................................................................................	0	1	1	1
+558	PF01476	LysM	PG_binding_2; 	LysM domain	Bateman A	anon	Bateman A	Domain	The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation [1].  This domain may have a general peptidoglycan binding function. The structure of this domain is known [2].	20.90	11.80	20.90	11.80	20.80	11.70	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.96	0.72	-4.06	156	27194	2012-10-01 23:00:54	2003-04-07 12:59:11	15	602	4537	7	7042	21185	3954	44.30	31	16.15	CHANGED	apV+pGD..TLhpIAppa.....................shshpplhphN..........slsssp.....lhsGQpLpls	....................YsV.pp.GD...o.Lhs....I.A.p.ca.........................ss..s...hp...p....l...h..p....h..N....................s..l...s....ssp..........lhsGQpLpl..................................................	1	2348	4523	5983
+559	PF03466	LysR_substrate		LysR substrate binding domain	Bateman A	anon	Bateman A	Family	The structure of this domain is known and is similar to the periplasmic binding proteins [1].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.20	0.70	-10.87	0.70	-5.23	415	85941	2012-10-03 15:33:52	2003-04-07 12:59:11	15	39	4494	158	20277	62785	6990	202.80	15	67.81	CHANGED	pst.pG..pL+lus..sshu...tthlsshlspFpp.p.aPt.....lplplptss..tplhchltpGplDlulhht.............tsssltsp.Lh.ppphsllss...ssa...............Lsp.......ttsl.shpcLtp..pshlhh..p..sss.......hpphhpphhppt......shp.........phthpssshpshhphltsGhGlullPphhht..p.h...tpsplh.hslss.........sht.tshhllhtpsp..h.ss......thpshhchltp.ths	......................................................................................t....pG..plplu.ss...s.s.hs.....tth...l.s...s..h...l.t.p..a....t..p.......p.....a.....P..p...................l..p...l....p.......l.....t...........t.......s...........s........................p..........h.....h......c..........h............l..........t.....p.....s.............p....h..D..l..u...l..t..h..tsh.................................tss.s.l...t....s...p....L....h....p........p.........p..h..h.hl...s..s........ss..a...........................................................l...sp..............ttsl...s....h.....p...c....L.....t.........p.......t..s....h....l....h.h.....p...t..sss.....................hpp..hh.p....p...h....h..p.pt...................sh..p.........................pht...h...p...s...s...s...h....p...s....h...h....p..h.l......t...s......G......h......G..........l......u..h...l..........P....p...........h........h.......h....t...........p..h..........t.p.....s.......p..........L.......h........h.s.l..st.........................tht...hs..h..h...l....h...h...p.....p.....p....p..........h....s.s.......thp.thhphlht...t.......................................................................................................................................	0	3804	9358	15032
+560	PF03816	LytR_cpsA_psr		Cell envelope-related transcriptional attenuator domain	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.81	0.71	-4.30	37	6551	2009-09-11 05:59:27	2003-04-07 12:59:11	9	20	2068	19	1112	4741	444	152.40	32	38.41	CHANGED	RoDohhllplssppcpsphlSIPRDohVpl............ss........p........hpKlssAhshG..................usphshcTlcphhu.lslDaYstlsapuhtpllDslG..GVcVssspshp.........sst.........................................hphpsGpppls.GcpALsasRhR+sss.G.....DhuRhcRQppllpulhpchts	.....................................................................RoDohhlhslss..p.s..c..p..s..pllSlPRD.o.h.lp.Is...........................sh.............p.............tsKlNtAa.shG......................................Gsph.shcTl.cp.h........h...s.......l...s...I...-....aYsplshpuFtcllDslG...GVc.Vss.......sh.......s..hs...........pss...............................................hp..h.p.t.G.....p....p.....p.Ls..Gcp.ALs...asR...hR..........p............ss....s.....................G............Dh.........s....R.tp..RQppllpulhp+hh.s..........................................	0	408	799	997
+561	PF02847	MA3		MA3 domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain in DAP-5, eIF4G, MA-3 and other proteins.  Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains [1].	20.70	20.70	20.70	20.70	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.14	0.71	-4.37	29	1720	2012-10-11 20:00:58	2003-04-07 12:59:11	12	37	326	24	1096	1714	25	110.00	21	15.93	CHANGED	h++chttllp.EYh..tDhpEAspsl.pcLths..phctclV+hhlshsh-c....pptpchhuhLLpchhptshlsspphppGF.chhs.sh-DlslD...............lPpshphlupFlu+hltsshLs	....................................c+plhhhlp.phh........D.hpEAhppl....pc.L....ph......s.....p......hp.....t......c..............l................lph.hlptsh-c...........pphpchhuhL.lppL.s.....p..t......s..h....htppp..h.ppuFh.chh....c...ph...c..-...l.tlD....................................................hs.thp.l.uphhuchltsshl..........................................................	1	344	582	853
+562	PF01454	MAGE		MAGE family	Bateman A, Wood V, Finn RD	anon	Prodom_3141 (release 99.1)	Family	The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown.  This family also contains the yeast protein, Nse3.  The Nse3 protein is part of the Smc5-6 complex [2-3]. Nse3 has been demonstrated to be important for meiosis[3].	25.00	25.00	25.80	25.30	20.80	22.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.39	0.71	-4.97	47	1361	2009-01-15 18:05:59	2003-04-07 12:59:11	14	13	248	3	734	1407	0	168.80	36	45.07	CHANGED	LVpalLhK.ptKp..PIp+u-hlctVl+ca.......+cpF..scIhpcAucpLchlFGhcLpEl-sp.............................................................s+sYlLlspLshs..................ssh..lsss...pshP..............................+sGLLhllLulIahpGNpssEpplWchLphhGlhss.c....cH.laG.-s+KLl.........op-hVppcYL.cY+.plssocPscaEFh.W..GPRAhsETSKhKV	....................................................................................LVpaLLhK.ptKp...PIp+u-ML..c..lhcca........cchF...PpIhp+AspplchlFGlcl+ElDsp..................................................................s+sYlLlspLshs..........................................ssh...lsss..pshP..........................................+sGLLhhlLulIFhp......G.......N......pusE...........pp.....lWchLp.t...h.G..lhsu..p...........cH.laG.-s+...+Ll........................................Tp-hV.ppp................YL.c...Y...............+....p.............V.............P..s....Sc..............P...........s..c..YEFl.W..GPRAhtEToKh+V....................................	0	103	147	224
+563	PF00390	malic		Malic enzyme, N-terminal domain	Finn RD	anon	Prosite	Domain	\N	19.20	19.20	19.20	19.20	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.02	0.71	-4.70	48	7633	2009-01-15 18:05:59	2003-04-07 12:59:11	14	36	4079	97	1959	5725	2415	136.20	38	27.44	CHANGED	ps+pEhlah+hlpsp...-.hPllYTPsVupsCppauc.hcpsp..hahohssht...h.t.h.th.......plhVlTDGstILGLGDlG.huGhslslGKhsLasshAGlcPt.slPlhLDsGssp.t.hts..YhG....R..s....thlDcFlcslpphasspshIpaEDhusspAFplLc+a+	.................................tc.phh.hp.ltsp.....c.LslsYo.PsVutsCpphsct........pp.s.............h.....hahsh.s..sh............................................................VhV.los..Gp..u...lLGLGslG..huuhs..............l........GKhs.....La.............p.....thuGl.c...s.....hsltlDst..............................s-chlpslp..th..sh............uhlph..EDhtsspsF.l.p+h+.............................................................	0	602	1170	1596
+564	PF03949	Malic_M	malic_N; 	Malic enzyme, NAD binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	23.50	23.50	23.50	23.50	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.45	0.70	-4.83	66	6923	2012-10-10 17:06:42	2003-04-07 12:59:11	10	36	4103	83	1803	5218	2322	236.30	38	43.02	CHANGED	.QGTAsVslAullsAl+lsucs...l......p-h+lVhhGAG..uAGlulschlhpt.....Gls....t...cplhhlDpcGllpcsR.ss..h......s.....shptt....aA+ppsphp.............hsLt-slcss..slllGsSt.ssGshsc-hlcpMup.........+PIIFALuNPss..EhpP--Ahphssutsl.ATG...........+o.hPsQsNNslsFP..GlhhGslsspAppIs-cMhhAAAcAlAshsspc..............phst.shllPshtchR.luhplAhAVuctAh	......................pGTAlVshAullsAL+....l.s....u+p..............l..............p-...h+lVh.GAG..uAGlu...hschllsh.........G..lp............hcplhhsDp..................p.....Gllhcs..R....s.s...L........s......thppt...........aApp.s.st.t.................................toLt-slcsu..Dlhl........Gl..........S....s....ss...s......hopEhl+pMup..................cPIIFALuNPs.....s..EhhP.cp.Ahphss...sts.hA....TG..............................................R..o.........t....a..PsQsN..N....sLsFP....GIhhGsLss.tA.pp.Is...--Mhh.AA..u.c...........AlA.phsp...t..p..........................ph.u.....s...hllPpshD......R..l.hplA.AVAcsA.....................................................	0	555	1086	1472
+565	PF00629	MAM		MAM domain	Bateman A	anon	Prosite	Domain	An extracellular domain found in many receptors.	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.29	0.71	-4.46	92	3415	2012-10-03 19:46:52	2003-04-07 12:59:11	18	308	158	2	1950	3145	308	149.40	23	28.95	CHANGED	CsF...Eps.....hC.uappsps...ssh..cWpp.hps.ss.......suPttD+ohss........Ga.ahhlpssts....ttGp..........pA.pLhS.hh........stss..........stC.lp.FaYah.hGpsh....Gs.Lplhlcpp...........tsttph.....lWph.sGspu......spWppsplslss....sppapllFEu.htus..stt.GslAlDDlplp....ps....tCsp	.........................................................................CsF.....-ps......hC..s...ap....p.......ttt...............ssh.....pWph...ps...s......................sP..hDpohts.........................Gh.a..h..h..lpssts......t.up......................pA..pL.h.Sshh.....stss.......................stC...lp..Fa.Y.ah.....h.....Gtsh......................Gs...L..p..l.hlptp..............................tth.tp.h.....................lW....ph.....s..u....s.p.u...................stW..p..p.s.p.ls.....lss.......sp.....ta............p..l..lF...c..u...h.hst................s.t...us..lA.lDDlplt..t.....C..t........................................	0	938	1052	1428
+566	PF03999	MAP65_ASE1		Microtubule associated protein (MAP65/ASE1 family)	Bateman A, Wood V	anon	Pfam-B_12512 (release 7.3)	Family	\N	21.80	21.80	22.50	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	619	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-13.08	0.70	-5.92	6	605	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	273	3	390	587	4	449.20	20	74.33	CHANGED	hpssplsclcpcspsshpctccEs..sptppullppIustcsElssL...........sphLc.......................................tthshhpp.cshshh....+Lccpl-pL....................RcphspRhsElpELhcQ.ppLCppLGp.sLsh.........h-sssLs.....Ech-phRp+lspLc-p+spRLc-hssl+psIpphhchLspp.t....sshEpclhs............ss+slo.EshspLpphhcphpsp+pcpt-+lcslpsplppLWsRLphosE.tp...............hp-Aoshoppohcl...lccElpRLptlKppplKphIEphRlEIpEhWDphhhSpEpR+p..Foshap-hhs........EpLLEtaEsElccLKphhsspKcIh-LlpcatpLhcchctLEtpusDsNRas.sRG....Gp..L.LKEEKpRKplsp+LPKlpppLptclpsaEscpspsFLhcGpslLEhhu.......spWEc+RppKppupspKKsssppss.hcss.ts..sssPpTPssp+sstslsssTsuht+s..hppsppptpsossstpoGsh+p+ssspRh.ssssp.suAppuptssh.RsttssssuptssSssptp.pos.sshhhspshshshcpssspsphpssspsspptcslppspsusssps-soostpsu	......................................................................................................................................................................................................................t....................................................h..............................................................................................................................l....hp..h...............................................................tt.ttpRhpph...tt...l...tt...p....p....h......pt..............................................................h.t...t.s.ls............pplpphptplppl....ppchp.pRhpph..phh...pplhph...ht...Lsh.s.............p.ht...t......h..t.............................................................tt.pths.l.sp....pslt.pLpphh...........ppLpt...p+ppp.pp.....h...........pplttpl.pLW.phh..p...h..s...tp-pp...F........................................h.tt.s.t....s....hs....h...phlpt...........hp.ElpRLppLKtp..ph+ph...l.p.......h+..-lpphhcth.a......h....s...-...p...ttt.............h.....h...h....h.....-.s.hs....................................p...p...L...L.p.h-.tpl.tclcp.hts++plhchlp+a.phhpc.p.LEp....hs.pDss...........Rat...sRG........up........L..L+ct.cpt+tlh...pc.lPt..l.ppLt.tp.lptWE....p....cp.......s.p...s.......F.h.h.pG.....phlphlp.......................h...p..t.p...c............p.+.......p....p........+...p............p.+...p........h....t....t.t..............t...t...t.p.............t..t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tt..................................................................................................................................................................	0	110	216	309
+567	PF00917	MATH		MATH domain	Bateman A	anon	Pfam-B_1602 (release 3.0)	Domain	This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans [3].	21.20	10.00	21.20	10.00	21.10	9.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.59	0.71	-3.86	52	3261	2012-10-02 00:06:50	2003-04-07 12:59:11	21	124	446	92	2107	3079	7	124.00	17	25.90	CHANGED	lcNhSphp.......pspphhs.shpp+ashsWp................lplhppss.......ahulaLpCtpt..ps..........hpWslpschplpllsssGpp.........hppphp.....psFsps.................................hshGhsp.....alpacplppch...lhcDolhlcupVcI	................................................................................ht.h...............thh..s..s.h...h.t..h..tG...h.p...Wp..........................................lpla.pGss................pssalS.l.alpl..h.ps.t.ps.........................tWsh.p...s..p...h...p..lpl..ls..p..p..spp.................ptp.p...........ppF.s.pt........................................................................................psh.G.atp...........Fhp..hp.pl....p.ptt.......a..l....h..s..D.s.lhlpspl..........................................................................................	0	726	1040	1659
+568	PF01429	MBD		Methyl-CpG binding domain	Bateman A	anon	Bateman A	Domain	The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [1].  DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [1]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.56	0.72	-4.45	16	1074	2012-10-03 08:51:45	2003-04-07 12:59:11	14	66	135	6	573	1046	14	75.90	25	10.19	CHANGED	hpppp.tcssL.tGW+Rchh.RpsGpph....................s+hDlhYhu...........P.sG++h+ohs-lhpYLppss...............................................hphppFsFssthhhsp	............................................................................................t.......p.sL..GW.pRchh.....R...p..t...Gt.ph.......................................tch.-lhYhu..................................P...sG+.chRoh..s-l....hcY...Ltp.ss...............................................................................................h..ppFsFpsh.....hht........................................................................................	0	130	240	380
+569	PF03062	MBOAT		MBOAT, membrane-bound O-acyltransferase family	Bateman A	anon	Pfam-B_2359 (release 6.4)	Family	The MBOAT (membrane bound O-acyl transferase) family of membrane proteins contains a variety of acyltransferase enzymes. A conserved histidine has been suggested to be the active site residue [1].	20.90	20.90	20.90	21.00	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.26	0.70	-5.31	41	4677	2012-10-01 20:09:06	2003-04-07 12:59:11	14	27	2309	0	1785	4135	489	287.90	18	62.65	CHANGED	hhthhhhthphhslhhhhslshhshphluhhhphtcs..................................................................................hhpthshhcahsYlhahs...................shhsGPhhpapcahpthc.t..hphthh..................t.hthulthlhhshhhhhhhthhlshhhhthlphhthhp......hshhhhhhhhhhhthhhha...th.hhshuhshhhGlt....................................ts.sh.psh.tspshpcahcpWphslspWLtcYlYhphh...........hhhtphhuhhhsahlsulWHGhphtallashhpslhlhspphhtphhphhthtttttththhthhhthhhhhhhshhhshhhh	..............................................................................................................................................................................................................................hhh.............thhh.hulsh....h....o...h......p.l.shh...h..-hhc..t.............................................................................................................................................................................................................................................hhtphsh.hpaht.al.haaP...................................................................plhu..GPlhcapc.hh.pp.h..p....p....h.p...ph..........................................h.t.t..ul.t..h.l....h..h..G.h..h..h.c.hl..l.......u.........h......l.s....h...h..h......h..t...h...h...p..t..........t...........................................................................................h.......h....h....h.h....sh...h...ta.s..h........l.....a..h.cFsu....a..s...h...A.l.uhuh..hhGhp..................................................................................s..NF......psa.h.u.psl..p-F...W.p.+WHholspWh.+..cY.l.Yh.hsh................................................pp.thh.t...p..h....h....s.....h.......hl.sah..lsul.WH.....G..h..........s.h.t..a....l............l..........a.....G..h...........h....p..u.h.hh..h....h...tp..h....h...h....p........h....h....t......h................h...................t....t...h....h...h.....h.....h..........h...h..h..h...h.......h.h.hh....h.......h......................................................................	0	630	1009	1447
+570	PF02820	MBT	mbt;	mbt repeat	Bateman A	anon	Pfam-B_526 (Release 6.2)	Family	The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein Swiss:Q9VHA0. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.	20.20	20.20	20.30	20.60	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.19	0.72	-4.06	18	2104	2012-10-02 16:56:36	2003-04-07 12:59:11	13	50	103	159	1180	1975	0	72.60	33	29.03	CHANGED	MKLEAlD.pssphlClATVspVhGpc.Lpl+aDGacsph....DaWsph-.SsDIaPlGWC-tsuctLpsP.shtppth	..............................................................MKLEul..D......p...s..s....p...h.h.p..lAT.V..s.cl.......h....upc...lhl.....+.....a..........D.G....h..c...ssh....................DaW...s.phs.S.scIaPVGWCpps..G..p....Lp.PP.sh.....h...................	0	218	298	671
+571	PF02470	MCE	mce; 	mce related protein	Bateman A	anon	Pfam-B_475 (release 5.4)	Family	This family of proteins contains the mce (mammalian cell entry) proteins from Mycobacterium tuberculosis. The archetype (Rv0169), was isolated as being necessary for colonisation of, and survival within, the macrophage [1]. This family contains proteins of  unknown function from other bacteria.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.65	0.72	-3.98	125	12284	2009-01-15 18:05:59	2003-04-07 12:59:11	15	19	2490	0	2643	8745	850	86.00	22	29.09	CHANGED	sshplpsthssu.sGLpsG.ssVphpGlpVGpVps..l.............p.sspp......lplphplp...............................................psh............................hlspsspuplpst.sll.Gt........................................palslpss	.................t...plphphs.su..sGLp.sG..ssVphp..GlpVGpVpsl........t.............h........ssss.pp....................lplph.plp......................................................sph.................................hls.p.ss.p...u.slps...sll..Gt..........taltlp..........................................................................................................................................................................	0	540	1469	2139
+572	PF05053	Menin		Menin	Moxon SJ	anon	Pfam-B_5848 (release 7.7)	Family	MEN1, the gene responsible for multiple endocrine neoplasia type 1, is a tumour suppressor gene that encodes a protein called Menin which may be an atypical GTPase stimulated by nm23[1].	19.20	19.20	19.70	19.20	18.70	18.40	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.08	0.70	-6.35	3	147	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	84	8	78	156	0	425.50	46	94.18	CHANGED	MGl+usQKoLFPLRSIDDVVpLFcuELsSs.EPDLsLLSLVLGFVEHFL.........AVNRVlPVNVP-loFpPosusDPsuGNSs.FPVV-LsLIAALYcRFpAQIRGAVDlSpYPKPuGsSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSaIT.....GTKLDSSGVAFAVVAACQlLGLKDVHLALSEDHAWVVFGpsGEETAEVTWHGKGNEDRRGQTVsAGIsERSWLYLKGSYM+C-RsMEVAFMVCAINPSLDLHTDSlELlQLQQ+LLWLLYDLGHLERYPMALGTLADLEElEPTsG+.SPLoLY+KAIESAKTYYRNEHIYPYMYLAGYHsRpRcVREALuAWA-AAoVIQDYNY.CREDEEIYKEFFDIANDVIPsLLKEsASutEAc..-Et.tEpp.tptuthSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATaLVQSLoRFDuQIRQKVsIlo+E..................sEAsEu-EsuGEEAREG.RRRGPRRESKs......................................-EPuGutSPNPcLPApNpNssospsuss.GucRKsuAoTsGsAssscNGSoosVPlPouSpP..................PphptG..................PVlTFaSEKMKGMKELLlAsKlNSSAIKLQLTAQSQVQMK...+QKsSAouDYTLSFlKRsRKsL	..........................................................................................ttthFPlpshssllplFtttLt......p...EPDLsLLSlllGhlE..L..................s.stshsss.....sth....t....................sh...FPshphphltuLYt+F.s....hls..h....s.h...t....tt.uoREllKKVSDVIWNSL...RS.aKDR.AHlQsLaSalo..........GsKLDs.GVAhAVVuuCQhLGh+........DV+LAlSEDHAWVlFG...p.t.pThEV.TWHG..KGsED+RGQslt.........sGl.tpt.SWLYltG..hhCsR.tMEVAhhVsAlNsSl.......shpo....DshElhpLQQpLLWlLYDhGaLc+YPMALGsLu-LE-...ht..........o...............s.....................p.ss...platcultuuppaYp.spHlYPYhY.usa.h.R......h.hp-....Ah......tsWAps...upVhp.YsY.sR-DtEIYKEhh-lAN-lIP.hh+.ts....p........................................phLppspsau.lLpFYDGIC.WEEsu.TPlLHl.sWAp.Lltsls+Fp.plRtpl.l....p..........................t..t...t.................t.........ps....pp.................................................................................................................................................................................................................................................................h...........................................sh..l.h.StKMtsh.thl..s.t.+lNstA.htL.lTAQS.sp................................h........................................................................................................	0	32	35	60
+573	PF00149	Metallophos	STphosphatase; 	Calcineurin-like phosphoesterase	Dlakic M	anon	Dlakic M	Domain	This family includes a diverse range of phosphoesterases [1], including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD Swiss:P13457 or yeast MRE11 Swiss:P32829. The most conserved regions in this superfamily centre around the metal chelating residues.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.44	0.71	-4.92	324	31320	2012-10-02 19:15:56	2003-04-07 12:59:11	23	436	5141	215	11462	33578	5742	205.20	13	48.44	CHANGED	hplhhhuDlHsphtph.............................................hthhphttptpsshl.lh.sGDhsspsthshtthhhh.....................................................................hhthphst.hhhlhGNH-htthsphhhhh.th............................................................................................................................hhht.thhthhhphhshh.htthtshpllhsHssh.stht...........................................................................................thhtthhtptphchlltGHpHt.	..................................................................................................................................................lhhhuDl.H....h.p..htth.......................................................................................................thh.h...p...h....t...t.....p.........t...s.......s.....h........l....l.........h....s..........G.D....h......h......s........p....s...s.........s....t.s.h.thh...........................................................................................................................................................................hhhh..p..h......t............h..h.....h.....l.h...G..NH-....h.t....h.......h....h.....t....h....h.....t..........h.......t.....t...h...........................................................................................................................................................................................................................................t....h.....h.....t......h......t..................t.............h......h............h......h................h......h...............h......t.........t........................p......h........h......l...........h.....h............s.......H......t...s...h......s.t....................................................................................................................................................................................................................h..........t....................t.....h.......p..h....h...h.h.uH.h................................................................................................................................................................................................................................................................................	0	4014	6855	9602
+574	PF01420	Methylase_S		Type I restriction modification DNA specificity domain	Bateman A	anon	Bateman A	Domain	This domain is also known as the target recognition domain (TRD). Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification.  The host genome is protected from cleavage by methylation of specific nucleotides in the target sites.  In type I systems, both restriction and modification activities are present in one heteromeric enzyme complex composed of one DNA specificity subunit (this family), two modification (M) subunits and two restriction (R) subunits [2].	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.11	0.71	-4.27	65	11631	2012-10-02 00:09:28	2003-04-07 12:59:11	14	41	3019	14	2039	9932	1120	165.50	14	72.39	CHANGED	s.cWc.phpLs-lhcl....tpGpt.tpp..phtpsGph...........Palsss.thps...............thhsttpphhhp.tsslhlstp........u....shGpshhtst....t.....h..hssp..phtslpsh..ph.h....chhhhalt....thhp......phpp........thussh.plstsplp..phcl.lP.......sh.pp......QptIschlcphtp...plpp.phhpplcp	.................................................................................................................................h...hpl..t...p....l.h..p.h...........t...u..t...t.......p.............t..t...t.s..t..h.....................................shl.phs.....t.............................th.....t............p.....p.....h..........h...h....p.....t.....ss....l.l..hstt.......................u..sh.G..p....s...t..h...h..pt.............p...............h.....h.h.s.p....t.h.hhl...psh.....ph...............p.a.l..hhh.lp.......th.hp............ph.p.ph......................sp.u..s..s..h.....p..l...s..t...s..p...lp.....p.h..l.s..l.P..............sh..pE.................Q....pc.Is....p....h....l....p....p....h....tp........th.t..........t..................................................	3	744	1450	1786
+575	PF01795	Methyltransf_5	DUF36; UPF0117;	MraW methylase family	Ayala JA, Bashton M, Bateman A	anon	Pfam-B_1376 (release 4.2)	Family	Members of this family are probably SAM dependent methyltransferases based on Swiss:P18595 [1]. This family appears to be related to Pfam:PF01596.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.69	0.70	-5.15	16	4779	2012-10-10 17:06:42	2003-04-07 12:59:11	14	11	4534	7	1122	4036	3223	300.00	42	95.42	CHANGED	phtHhoVLLcEslchLp...........l+ssG...lYlDsTlGtGGHoctlLppLsp.t+LhulDpD.pAlttAppcLp.a..ct+hsll+ss..Fsplhphhtct...............hltclDGILhDLGVSS.QLDps-RGFSFpcD.uPLDMRMDpossl.TAtEllNshs.p-LscIhhcYGEE+auKpIA+uIhctRc......ppPhpTTt-Ls-llppshPsht.....++t.......ttHPAs+sFQAlRIhVNcELppLccuLppAhchLsssG.RluVIoFHSLEDRIVKphF+-hsph..p.P.uLPhh.pthp.......hlT+KPIhPSpcElcpNsRSRSAKLRlsEKh	....................................t..pHhsVLLpEsl-.s.Ls...........................................................l+.ss.G..........lYlDuThGtG.GHSchl...L.p.p..L.sp...tG......+......L..............luhDp..D....pA...lttu.....p....p....p......l.p..h...........ssRhshl..+us....Fs.p.l.....t....ph..lpch.......................................................tl..tclDGILhD..L..GVSS.Q......LDp......sER..GFSa..p..p.D..uP.L.DMRM.............D...............t.................s...........p........u.....h....oAt-llNphstp-LsclhhpYG..EE..+...a..u+pIA+t.Il.p.t.R.p......p...p....P.l..po....T.t-Ls-llp.p...u.....h...Pt...tt...................+.c..................t.t.HPA.p.RsF.QAlRItVNsELptlcpu.L.p....p.A.h.c.h.L...............ts........G.G....RluVIoFHSLEDRlVKphh........+........c...t..........u.........p.s............................p.s...P........t......s.......l.......P...hh..........p.p.h...p.sh..........................hphl.s.+...K......s...l.......hPoccElppNsRuRSA+LRlAE+.h..................................................................................	0	409	743	952
+576	PF05060	MGAT2		N-acetylglucosaminyltransferase II (MGAT2)	Moxon SJ	anon	Pfam-B_6001 (release 7.7)	Family	UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II (EC 2.4.1.143) (GnT II/MGAT2) is a Golgi resident enzyme that catalyses an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [1]. Mutations in the MGAT2 gene lead to congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency,  unrelated to coagulation factors [2].	27.00	27.00	27.40	27.20	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.42	0.70	-5.54	10	200	2012-10-03 05:28:31	2003-04-07 12:59:11	9	4	105	0	131	210	0	274.60	35	75.24	CHANGED	sloLptRshl.shN..p....l.N.sDlaspLsp.........scllIVlQVHNRP...pYL+lLl-SLu+s..+GIscsLLIhSHDhYssElNcllpuIcFCpVhQIFaPYSlplaPssFPGssPsDC.pphcK-cAhcppC.Nuc.PDpYGpYRpu+hsplKHHWWWphNhVWDtL.ccs+sasGalLFlEEDHYlhPDhY+sLphlhshK.phCPsCtslsLGshsh.ops.uh-sthsEVhsahuscHNhGhAhsRslWcKI+sCucpFCoaDDYNWDWTL.tlshsChsp.l+sL..s+uPR..lhHh......G-C.GlHp....sssCpss.ssstplccls+..slpsphaPpslploc+ps.uhpush+sNGGWGDhRDRcLC	.............................................h............hN....thhs..........................phhlVl.VHsR....pYL+hLl.SLtps..psIppsLllhSHDha..-hspll.t.s.lsFC.....V.hQlFaPaShphaPppFPG.sPpDC....t+ptAh.htC.su...PD.aGpaRps.ch.sphKHHWWWKhp........hVapt.....l...c.hp.asGhllFlEEDHalh.Dh.hhhhphh.php......p.CspCt.....hlsLGsh........h..sh.hs.tpps-hhsahSs........a..NhGhAhsRssapplh.t..psppFCpaDDYNWDhoL.hls..t.s...h..............p.....................hh......sh...h.psPR..lhHh........Gc.C....GhHp......ppsCtsp..t..tp.l....pph.p..p.pt.hh..........tl...hl...t.....t.......t........pt.GGWGDh.RD+pLC..........................................................................................................	0	44	65	105
+577	PF02142	MGS	Methylglyoxal_synth; 	MGS-like domain	Bateman A, Mian N	anon	Pfam-B_220 (Release 4.4)	Domain	This domain composes the whole protein of methylglyoxal synthetase and the domain is also found in Carbamoyl phosphate synthetase (CPS) where it forms a regulatory domain that binds to the  allosteric effector ornithine. This family also includes inosicase. The known structures in this family show a common phosphate binding site [1].	22.90	22.90	23.00	23.10	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.10	0.72	-4.05	164	10875	2009-01-15 18:05:59	2003-04-07 12:59:11	17	65	4646	116	2605	7914	4421	100.00	27	14.06	CHANGED	sllshA+tL.tph.G..acllATuGTu.chLp.cs..Gls.hplsphstps.h.s......................hhchlpptpIp...lVlssh.shptsht.........-shs...lccss.phcIshsT	............................llphAptL.t.ph..G....aclhuTu.GTu....p.hL.....p....c.....s...........Gl.............s..........hpls..p...h..s.t.t..s......h.hsuc................................................................................thhshlpp...t.....c...Is.........lVlssh..hshptsst................-stsl.c.css.phcIsssT...............................	0	852	1659	2184
+578	PF01769	MgtE		Divalent cation transporter	Bateman A	anon	Bateman A	Family	This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)	21.50	21.50	22.00	22.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.48	0.71	-3.88	17	3706	2009-01-15 18:05:59	2003-04-07 12:59:11	11	18	2452	6	1251	2988	1805	127.60	28	31.59	CHANGED	hlPhlhGhsGNhGsphuohlsptLslGplp........tph.plhhcphthshh....luhlhu..shshlhsshh.....sssshlshsVssslhhshhlus...husllslhhc+htlDPs.huuPllTolsDlholhlh.hhlu	.......................................................hhPllsuhGGNs.....GsQsholllR....u.lA.....h....s..p.ls.......................ps.h.h.p.l.l.h+..E.l.s.....l.u......hl........................hGll.hu...........hh..h...h..l..h..s...h..h....h..........................................................h....t.....s.............h..h....l....u.h..s.....l....u.....h....u.h...h...s.s.l....l.husl......hGshl...P.hl..hc.+h.slDP.AlsouPhl.TTlsDlh..Ghhla.hsl....................................	2	418	721	996
+579	PF00993	MHC_II_alpha		Class II histocompatibility antigen, alpha domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1288 (release 3.0)	Domain	\N	20.60	20.60	20.80	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.69	0.72	-4.41	51	3084	2012-10-03 22:02:01	2003-04-07 12:59:11	15	5	277	142	138	2606	0	76.50	45	55.24	CHANGED	DHlutY.hthhQshsssGpaha-FDG-EhFYVDLc+KEsVWpLPpFuchhoF-...sQsuLpsIussKtNLslhhKtsNsTssss	..........................hthhts..s.s....s....G...pasa-FDGDEhFYVDlpKKE.......TV.WpLP.F.u.catoF-.....sQGALsNlAssKtNLslhhKpSspss.................................	0	7	18	38
+580	PF00969	MHC_II_beta		Class II histocompatibility antigen, beta domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_331 (release 3.0)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.49	0.72	-3.99	121	17595	2012-10-03 22:02:01	2003-04-07 12:59:11	14	5	639	123	215	16212	0	69.80	52	67.66	CHANGED	u-CaF.pNGTc+VRalsRahYN+EEa...lRFDSDVGcahAlTELG.....c.sAEhWNSpc-hLEppRAtVDThCRHNYtlhp	..................cChF...N..G..T-RVRalcRYhYNpEEa....lRFDS..D..V..GcahA.s.TELG......cssAEa........WNSQp.-lLEppRAtVDs..hCRHNYtl.........................	0	23	41	74
+581	PF02816	Alpha_kinase	MHCK_EF2_kinase;	Alpha-kinase family	Egelhoff T, Ryazanov A, Bateman A	anon	Egelhoff T	Family	This family is a novel family of eukaryotic protein kinase catalytic  domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases [1,2] and Elongation Factor-2 kinase and a bifunctional ion channel [3]. This family is known as the alpha-kinase family [4]. The structure of the kinase domain [5] revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.	21.30	21.30	21.50	21.50	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.47	0.71	-4.63	63	765	2009-01-15 18:05:59	2003-04-07 12:59:11	13	29	138	16	532	775	15	177.80	24	20.05	CHANGED	FupGsh+tsathh.h....................................ttsphhVsKhhpp.....t.........................p..............................c.hhp-spsphhupphscpFNpph....tts..pp...lp..............ahshh.lhchpsps........................hhhsEta......lpG....capKYNsNt..Gah..............tppsthtphhpAFSHFTYphSptphllsDlQGls...s.......hLTDPtIpot..s.sph....h..u..sshGpcGltpFht.pH.pCsphC	......................................................................................................................................tGthR.shtsh.h....................................p..sp.hlhK.hh...........................................h....................................p.hhhp-..h.p.ph.......hu.phhsptFsph..............t.s.t......p....................................hl..hh..lhp.h.psp..........................hhhlEph......l..pG........ca.h.Kas..sNs..uhh...................................ttssp..h..tphhpAFoHaoYphops....phlVsDlQ......GVs....p........................hlTDPplhshp..tph................h......G..sNhG..pulptFht...pH..pCNphC........................................................	0	305	370	431
+582	PF02854	MIF4G		MIF4G domain	SMART	anon	Alignment kindly provided by SMART	Family	MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G).  Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA [1].	21.00	21.00	21.10	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.33	0.70	-4.92	41	2682	2012-10-11 20:00:58	2003-04-07 12:59:11	14	57	339	22	1754	2678	51	203.50	17	26.69	CHANGED	t+plpulls+ls....pphpphhpplhphhhpp........phhppllphl...hppshtps......shhshhApLsstlspphs....................pFsphllsphhppFpp...................................ppppptsppcthshl+FluELhphph...lspt.hlhp......hltpllpphsc..................pplchlhplLpssGphLp.....................................................ppsppthcphhpphpphhtp................................tphs.clcahlpslhpl+psp	......................................................h...hpshls+ls.....pphpplhpp.l.hph..hhpp..........................thhptllphl....hpts...ht..ps............phs...haApl.ss.t.ltpths..................................................................pht.p..hl...ls.ph..c.pFcp....................................................................t.p.t.c..t..t..s....p.....p.......c.t.hs..l+Flu-L.h..ph.ph.........ls.p........t...lhhp..........hl.t.p.....L.l..pp.hpc.............................................psl.-hlspl...Lpss.....Gt.Lp...............................................................................pp.s.p...t..t.......hc...phhp......phpphhpp...........................................tphs.c...hc.....ahlpshhplpt.........................................................................................................................	1	585	916	1394
+583	PF02815	MIR		MIR domain	Bateman A	anon	Ponting CP (EMBL archive)	Domain	The MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function [1].	24.70	24.70	24.90	24.80	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.31	0.71	-4.76	30	1582	2012-10-02 19:42:32	2003-04-07 12:59:11	14	76	302	11	968	1488	5	172.80	24	10.35	CHANGED	GaL+utcslh........htucQpphhsh..........sch-pssc........................WclEs.pps.h...........puutscW..........GshhRl+HlsTG+YLtuc-cp..............................sslscp.chpp-sosYshpsh.ts............................sDt....lplhcpcsssshusspl+stcohhRLpHhtTusaLpupsscl..sthG.tppEpsshpp.....tssh.hhEpc-shs.Ls	......................................................hL+utshhh..........htu.p.Qpp.s.h.sh.......................................s.pt.D.p.ssp....................................Wh.l.c.s.....p..p..s.s.h..............pust.h.ph........................GshhRLpHlsTu.+hLtuccst..........................................sslspp....ptE.so..sa..s.h..psh...ts..............................................................................pDh......hpl.h......phc..s.....p.....p............t..........t...s....p...l..ps.hso.hhRlpHh..s.os...saLpspshpl....sphu.tptEhs...shtp........sph..................................................................................	0	275	441	727
+584	PF04212	MIT		MIT (microtubule interacting and transport) domain	Bateman A	anon	Crosby A, Patel H	Domain	The MIT domain forms an asymmetric three-helix bundle [3] and binds ESCRT-III (endosomal sorting complexes required for transport) substrates [2].	28.30	28.30	28.30	28.30	28.20	28.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-8.98	0.72	-4.09	82	1334	2009-01-15 18:05:59	2003-04-07 12:59:11	13	33	342	20	840	1237	38	69.40	27	14.39	CHANGED	hlppAhchlppAlctDp...tu.......papp.AlphYppulchhhpulphc......p.sspp+ph..l+pKhppYlsRAEpl+phl	........................hpcAhphlppAl.ctDp.......ts.......pacc.AhphY.ppul-hhlp.....ulph-................................p.sspp+ct.....l+pKhppYLsRAEpl+ph............................	0	236	365	592
+585	PF00153	Mito_carr	mito_carr;	Mitochondrial carrier protein	Sonnhammer ELL	anon	Prosite	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.00	0.72	-4.28	188	37736	2009-01-15 18:05:59	2003-04-07 12:59:11	22	243	698	9	25106	35824	767	94.40	21	75.41	CHANGED	pphshhtphhuGuhAGsh.utssstPlDhlKsRlQ................................tts.tpa.puhhcs...........hpplh.+p-G........h.tuLa+GhsssllthsstsulpFs....sY-thKphhhptt	.......................................................................t....h.phh.uG...u.h.u.....G....s....h.....u.......s.........h...........h..........s..........h..P....h........-..........s...l..K..s.....R.hQ.....................................................................................t.tt..tph....p....u......h...h....s.s......................................................h..p.p..l.h...+..p....-......G........................................h...tu....l....a.....+..........G...h.s........s..s.......l..h...p......h......s..s..h........s.......u.....l....has....sY-hh+phh....t............................................................................	0	8054	13500	20193
+586	PF03637	Mob1_phocein		Mob1/phocein family	Bateman A	anon	Pfam-B_1830 (release 7.0)	Family	Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [1]. This family also includes phocein Swiss:Q9QYW3, a rat protein that by yeast two hybrid interacts with striatin [2].	21.90	21.90	23.80	22.00	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-10.99	0.71	-4.60	12	1280	2009-09-10 23:30:30	2003-04-07 12:59:11	12	11	310	3	872	1169	11	157.60	35	62.79	CHANGED	pphspsoLsuu..slpphVpLPpGpDhs-WlAhpsh-FFsplNhlYGolsEaCT.poCPpMousspa-YlWtD..phtK.PsphsAspYlchlhsWhpsplsscplFPo+sul.FPpsFht.lsppIhpRlFRlauHlYh+HFcplhplphEsHlNspFpHFhhFspEFsLlcp+-htsLp	.............................................hhptsltps..slcphVpLPp.G..Dhs-WlAhp...................s.....h........-....Fapp...lN..h.l.a.u..sl.......s........-........h........C....o.p..oC..PhMs...As...s.................p.a................pYhWt-...................pht.+....Ph.ph.........sAs......cYhchlhsWlps.lssc...pl.FP........o.+.......h........u.......h...........s..F......P.....p...s........Fhp......h....sp...pIh..+....RLFRlauHlYhpHa.p...hhp..lt.EsH.....LNopFpHF.hhFhpcasLlstc-htsh.....................................................................	0	273	432	669
+587	PF00994	MoCF_biosynth		Probable molybdopterin binding domain	Bateman A	anon	Pfam-B_1258 (release 3.0)	Domain	This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation [1].	25.10	25.10	25.10	25.20	24.90	25.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.80	0.71	-4.79	149	13076	2009-01-15 18:05:59	2003-04-07 12:59:11	19	66	4239	129	3598	9529	4365	147.50	23	44.05	CHANGED	ullosGsElh...............tGpl..........hDsNu.hlsshlp..p.....hGh.plhths.llsD-.ptlppsl......htt.pp...DlllsoGGsusupcDhohc.............sl.tphhs........hhctlshp.st.................................................shh...hush...stt........s....lh.sLPGsPs...ushsshphhl..............PhLtp	.................................................llosGcElh............................tGph...............hDssu....hl...tphlp...p.............hG...h...p....l...h.....t..hs....l...ls...D.c........p.tl.p..psl..............pps.h.pps.............Dll.lo....oGG.s.....u...s.s...p.......c.......D.hThc........................................sl..t....ph.h...s..p......................h...hp.pluhp...tt.........................................................................hush..h..h.spt........................t.s...lh..sLP.G..sPs.ust.s.s.hpthl....Phl..t......................................................................................................................	0	1154	2293	3059
+588	PF03454	MoeA_C		MoeA C-terminal region (domain IV)	Bateman A	anon	Bateman A	Domain	This domain is found in  proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known [1] and forms an incomplete beta barrel.	20.40	20.40	20.40	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.06	0.72	-4.02	47	4409	2009-01-15 18:05:59	2003-04-07 12:59:11	10	31	3053	40	1367	3598	1140	71.70	25	16.06	CHANGED	puhlspshtsstsRpcalRshlp.....t...uphhspPht...tpsSuhlpolspAsuhlhlspsspt...lpsG-pVpVhhh	..................................uhhsps.h..p.p.s.s..s..RpcFhRutlp................tts.................Gp..h.h..lp.s...s.u........tps..S..u...hls.ohupANshlhls..tspss...........lpsG-hVplh.h..................	0	406	862	1156
+589	PF03453	MoeA_N		MoeA N-terminal region (domain I and II)	Bateman A	anon	Bateman A	Family	This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.	22.50	22.50	22.80	22.90	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.74	0.71	-4.89	52	5148	2009-09-11 13:37:57	2003-04-07 12:59:11	12	42	3304	40	1547	4152	1544	162.50	33	36.85	CHANGED	hhsl-EAhchlhshhtth.......sEpVsltcuh.GRlLA-DlhushslPsFcpSuhDGYAVRupDshsust...................tLpVluclhAGpssp.hplssGpsl+IhTGA.lPpGADAVVhhEpspttss........plplh..ptspsGpNlphtGpDlppGssllppGpplsP...tclulLAuhG	.................................................hslccAlp...h...l...h.s....t..h.p.shs..........sEplsL......t....c......u.....h...G.......RlLA..............c.Dl.hushs.lPsFcsSAMDGYAlR..s.s..D..ht.s.sp.......................................l..V.h.u..c..h..h.A..Gps.................p.....t.......pl...t........s........G...........p........sl.R.I.hTG..A..sl..P......p.........G........u.......D...u.V.Vh.Epspttss..........................tlp.lt.....ps..s...p....s.G.....ps..lR....h............tGEDlp.tGsll.lttGptlss..splulLAohG..................	1	471	975	1318
+591	PF02493	MORN		MORN repeat	Bateman A	anon	Bateman A	Repeat	The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).\	\	A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii [1].  It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton [1].	22.50	5.00	22.50	5.00	22.40	4.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.84	0.73	-6.99	0.73	-3.92	271	23538	2012-10-01 20:24:03	2003-04-07 12:59:11	15	292	1025	32	14186	22201	11255	21.80	32	29.18	CHANGED	YpGpa.ppGhtcGpGhhpassGsp	..............YpGpa..tss..p...t..p...G.p..G.hhhassG...............	0	8471	10144	12192
+592	PF03476	MOSC_N		MOSC N-terminal beta barrel domain	Aravind L, Anantharaman V	anon	Aravind L, Anantharaman V	Domain	This domain is found to the N-terminus of Pfam:PF03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.	21.00	21.00	21.20	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.28	0.71	-10.57	0.71	-4.40	16	1954	2009-01-15 18:05:59	2003-04-07 12:59:11	11	18	1430	1	823	1627	289	117.60	26	29.64	CHANGED	huplssLalaPIKSscuhulpcAp...lsstGhh....tDRtahlls.sc.G............phlTtRpcPpLshlpssh............psshLplsAP.....Ghssltl.lt.....s.ththtssplathshsuhcsG-..........tsuc.WhosaLups	......................plspLalaPlKShp.Glsls.....puh............h.s.s.p.GL............aD...Rt...aM....lsc....ss......G.............................ph...lT...t...R..ph...Pph...s...h..lpssh..................................................ps...sL..t.ls...us....................s.t.s...s.h...hl.t.hs............s.ttp.t..s...s.p..V..a.t.......s....p..h......p..u....h...sss.............................................th.sp.WhSthhu..............................................................................................................................................	0	218	430	658
+593	PF04643	Motilin_assoc	motilin_assoc; 	Motilin/ghrelin-associated peptide	Mifsud W	anon	Pfam-B_5485 (release 7.5)	Family	This family represents a peptide sequence that lies C-terminal to motilin/ghrelin on the respective precursor peptide. Its function is unknown.	19.30	19.30	19.80	19.30	18.30	17.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.78	0.72	-4.48	16	149	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	81	3	37	152	0	54.60	38	51.89	CHANGED	hlDPs...pspt-E-phcI+hsAPh-IGl+loucQhpcattsLE+hLp-lLhpps.pt..scc	........................psttt--p.pIphsAPF-lGl+loutQhppautsLt+hLQ-lLh-ps...................	2	2	4	8
+594	PF04644	Motilin_ghrelin	motilin_ghrelin; 	Motilin/ghrelin	Mifsud W	anon	Pfam-B_5485 (release 7.5)	Family	Motilin is a gastrointestinal regulatory polypeptide produced by motilin cells in the duodenal epithelium. It is released into the general circulation at about 100-min intervals during the inter-digestive state and is the most important factor in controlling the inter-digestive migrating contractions. Motilin also stimulates endogenous release of the endocrine pancreas [1]. This family also includes ghrelin, a growth hormone secretagogue synthesised by endocrine cells in the stomach. Ghrelin stimulates growth hormone secretagogue receptors in the pituitary. These receptors are distinct from the growth hormone-releasing hormone receptors, and thus provide a means of controlling pituitary growth hormone release by the gastrointestinal system [2].	21.90	21.90	22.40	23.10	21.20	21.80	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.82	0.72	-7.00	0.72	-4.14	6	118	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	53	1	32	126	0	27.20	59	26.77	CHANGED	VPIFTauElQRh.QEKEppKsp+KSLplQ	.GSSFLSPEHQ+h.QRKEsKK.PsuK.LpPR....	0	2	2	5
+595	PF01398	JAB	Mov34; JAMM;	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Finn RD, Bateman A, Iyer LM, Burroughs AM, Aravind L	anon	Pfam-B_738 (release 3.0)	Family	Members of this family are found in proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. This family is also known as the MPN domain [3] and PAD-1-like domain [4], JABP1 domain [5] or JAMM domain [7].  These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [7]. Versions of the domain in prokaryotic  cognates of the ubiquitin-modification pathway are predicted to have  a similar role [8]. 	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.47	0.71	-4.34	30	2882	2012-10-10 14:49:21	2003-04-07 12:59:11	16	61	451	19	1880	3177	141	110.70	23	23.48	CHANGED	pssppVhlpslllhphlcHhp+sspt.........................clhGlLlGphps-.........................slcltssFulPhpsspcsspsht.shp...ph.chhcph...............................sc.EplVGWYHopPsh.s..ossDlpspp.apphtss	.........................................................................pVhlpshslhphlc.....H..s.p.p....t..sth..............................cVhG.hL.lGph.s.sc....................................................slclpss..F....s.........h....P...p...........p.....ss..p...........s.s.....s.p.h...s.thp................phhchhcps..........................................sc...pllGW.Y....H....opP......sh...s....os........Dl.pspt.hpth...p..........................................	0	655	1015	1500
+596	PF01853	MOZ_SAS		MOZ/SAS family	Bateman A	anon	Pfam-B_3994 (Release 4.3)	Family	This region of these proteins has been suggested to be homologous to acetyltransferases [1].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.31	0.71	-5.06	15	1290	2012-10-02 22:59:21	2003-04-07 12:59:11	13	26	337	14	784	1296	19	175.50	49	25.71	CHANGED	h++PPGsEIYRcssISlFEVDG+cp.................plYCQNLCLLAKLFLDHKTLYYDV-PFLFYlLTEpDcpG.........sHlVGYFSKEKcSspsYNlACILTLPsYQR+GYG+hLI-FSYELS++EuplGoPEKPLSDLGhLSYRoYWspsllclLhchcs......plTIc-lSphTulsppDIlsTLppLs.hl+YhKspalIsls	..............................................................pHPPGs.EIY......R.......c.............s............s.......l..SlF...E.VDGc..cp.......................+..h..YCQNLCLLAKLFLDHKTLY..YD.......V.-P.....FLFYlhT..c...h...D..p...p...G.................................tH..lVGYFS.K..........E....Kp....S.........p.s.........a.NVuC...ILTLP...........Y.....Q.R+..G..........YG+h.LIcF..........S................Y..L....S...+....h...E.....s..............p..h..........G.oPE...........KPLSDLGhl..S.Y+uYWppsllch.Lh......p..h.p..s................................pl.o.....I.p....clSphTuhp.pDllpTLptLp.hlphhpsp.....h......................................................	0	270	410	629
+597	PF04117	Mpv17_PMP22		Mpv17 / PMP22 family 	Wood V, Finn RD, 	anon	Pfam-B_8493 (release 7.3);	Family	The 22-kDa peroxisomal membrane protein (PMP22) is a major component of peroxisomal membranes. PMP22 seems to be involved in pore forming activity and may contribute to the unspecific permeability of the organelle membrane. PMP22 is synthesised on free cytosolic ribosomes and then directed to the peroxisome membrane by specific targeting information [1]. Mpv17 is a closely related peroxisomal protein. In mouse, the Mpv17 protein is involved in the development of early-onset glomerulosclerosis [2].  More recently a homolog of Mpv17 in S. cerevisiae has been been found to be an integral membrane protein of the inner mitochondrial membrane where it has been proposed to have a role in ethanol metabolism and tolerance during heat-shock [3]. Defects in MPV17 is associated with mitochondrial DNA depletion syndrome (MDDS) and Navajo neurohepatopathy (NNH) [4][5].  MDDS is a clinically heterogeneous group of disorders characterised by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues.  Individuals with the hepatocerebral form of mitochondrial DNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids.  NNH is an autosomal recessive disease that is prevalent among Navajo children in the South Western states of America.  The major clinical features are hepatopathy, peripheral neuropathy, corneal anesthesia and scarring, acral mutilation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Infantile, childhood, and classic forms of NNH have been described. Mitochondrial DNA depletion was detected in the livers of patients, suggesting a primary defect in mtDNA maintenance [5].	20.30	20.30	20.40	21.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.11	0.72	-4.34	93	1477	2009-01-15 18:05:59	2003-04-07 12:59:11	7	21	327	0	1058	1437	41	66.50	24	28.41	CHANGED	hu.hl....-ups..hppshpclccpahssht.....ssahlWPhsQhlNFthl.PsphRllasshlulh.WssaLShhppp	................................s.hh....pups..h.pphhpcl+ppa.hsshh...............ssa...hl...W...PhsphlNFt.hl...P.h.p...h.Rllasshl....ulh.WssaLShhtt...........	1	361	595	889
+598	PF03587	EMG1	Mra1; Nep1; 	EMG1/NEP1 methyltransferase	Finn RD, Mistry J, Wood V	anon	Pfam-B_3290 (release 7.0)	Family	Members of this family are essential for 40S ribosomal biogenesis.  The structure of EMG1 has revealed that it is a novel member of the superfamily of alpha/beta knot fold methyltransferases [2].	28.20	28.20	28.20	36.20	27.80	28.10	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.25	0.71	-5.03	60	459	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	385	15	316	463	33	199.60	41	81.56	CHANGED	llLtcusLEhl.hp..................csphtLLssscHtshh..c+h...tc...........................s.ccuRPDIlHpsLLtlhDSPLN+.tGhLp.lYIH..TtcshlIpVsPpsRlPRsapRFtGLMtpLLc....+hplhss..utptLlclhc.sslsc.hlss...ssphlh..lSpcGphs...............................................phpchsp...........................................................................................................................pshs.hhlGuhs+Gc.thp.thsp....cp......hSIu.shsLoAtsssu+lssuhE	...................................................lVLppAsLEsh+h.....................t.p.pa.pLLNsDcHtshh...+Kh...s+............................-.ucsRPDIsHQsLLsLLDSPLN+..AG.hLQ.VYI+..Tt+sVLIEVsPpsRIPRTFcRFsGLM.............VQLL+....+hs..I+us.s.u.p.c+LL+V.IK.NPlo.-.aLPs....ss+Kls..lShs.u..thl...............................cs.p.-.hlp.........................................................................................................................tpcsls.lhlGAhA+Gc..hs.scas-.....cp........luIS.sYsLSAuhsCu+hspuhE.................................................................................	0	115	179	261
+599	PF03022	MRJP		Major royal jelly protein	Griffiths-Jones SR	anon	Pfam-B_1099 (release 6.4)	Family	Royal jelly is the food of queen bee larvae, and is responsible for the high reproductive ability of the queen.  Major royal jelly  proteins make up around 90% of larval jelly proteins.   This family also the sequence-related yellow protein of drosophila  which controls pigmentation of the adult cuticle and larval mouth  parts.	19.80	19.80	19.80	20.10	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.62	0.70	-5.20	20	978	2012-10-05 17:30:42	2003-04-07 12:59:11	11	6	294	8	455	1055	14	247.90	22	65.31	CHANGED	sSsa+lslDcCsRLWVLDoGllshsps......hCsPpllsaDLpTcc..ll+phclPpslsp....ssotlsslsVDhhcs....sCttsasYluDttuc...uLIVYshsscpuWRlpsp..thpsDPthsphslsGpsFphpDG......laGhuLushp.s....LYFpPLuSpp.asVsschLpspshtpss....phpphpslGs+u..oQusucuhsp.sGlLFauhlspsuluCWspppshsppNhshls..psscsLpassslKIpc.............pphlalLS....s+hpphhtsclshschNFRIhtsslsclhcsohC	...................................................................................................................ss.phhhD.t.ps+LWllD.sG..h...h.......sh....t..............hs..sspllsh.DLp.o.s.p...........ll+ph.hstshhh.....soh.hssl...s.lDht.s........s.........tsasYlsDs...s...s...............ullVashtssp..u..aR..l...pp.......hhss..s....h......s..s.....h.s.....l.t.........s..........h....p...h....sG..........................h.u.hshs..s...................t...........s........phLYapshuopp.atls.TphLp........stsh..sp...pt..........tthp...l.G.p.+s....sp.ss..u.hhhDt...sGslahs.hppsulhphs..s...p.t........tp.h.th.lh...pssp....h.assshthst..........................pt.lahhs........sph................t......................................................................................................................................................................................	0	144	221	388
+600	PF04707	PRELI	MSF1; 	PRELI-like family	Mifsud W	anon	Pfam-B_5792 (release 7.5)	Family	This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.	20.40	20.40	21.70	20.40	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.85	0.71	-4.66	16	922	2009-01-15 18:05:59	2003-04-07 12:59:11	9	17	286	0	571	815	0	145.80	29	50.50	CHANGED	-pVssAahp+YPN.PhsspllusDVlcRc.lss.pGp.LhT.cRllphph.....shPcalc+..llGs..sp..sahhEpSslD.pc+ohslcopNloasshlpVcEpspYpsHs-Ns.shThhcQcApls..lhs.hhuhsstlEchuhppaspN.ssKG+cuhEallpp.lptp	..............-.VhtAhhp+.Y....P....N....Ph..s........spVlusDl..lpRp.lss...sGt.....Lto.cRllp.pp............thP....phlcp................l.huh.............sp..s.alhEcShl....Dsp.......p+....shp.hpo......pN..l.oa.ss.....h...l......p......VpEpssYp...s....ps.....c....s......s...s.....hTh.....hp.Q...pA.ls.......hh.u...h...hs.h.p.ptlEphhhppappN...spKGppshEhhlpp.....p.................................................	1	155	247	414
+601	PF00635	Motile_Sperm	MSP_domain; 	MSP (Major sperm protein) domain	Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.	22.80	22.80	22.80	22.80	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.16	0.72	-4.41	63	1788	2009-01-15 18:05:59	2003-04-07 12:59:11	21	69	335	35	1207	1567	9	102.30	22	37.32	CHANGED	hlplpP.sptlhhss.h.........ssspl..plpNsosp.pluFKlKoTssppYpVcPshGllpPspshplpl..hhps.p...ss..p.......pDKhhlphshs.tstssstpshpphhppsps	..................................h.l.lpP.t.t.lh.Ftt.h.........tp...hpptl..pl..p.....N.......s....o..sp...t.lsF..K........l........K..TT...sP..c....c..Y..p.V....c....Ps.s.G.l.l...........cP.tps.s.p.l.s...........l.........hh.p.s.t.....st.p................pD+Fhlpss.s..tsts.t......ht........s..............................................................	0	442	671	1055
+602	PF03820	Mtc		Tricarboxylate carrier	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	19.10	19.10	19.50	19.40	18.30	17.70	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-11.91	0.70	-5.77	9	716	2009-09-11 12:47:20	2003-04-07 12:59:11	12	12	283	0	439	638	7	268.20	38	91.85	CHANGED	aD.STahGRs+HFhphTsPhsLlsopppLpcu+pIVpcY+pGphsssh.Ts--lW+AKplhDSsaHPDTGEphhhhGRMSuQVPhNhllTGGML..shYpsssuVVFWQWhNQSFNAlVNYoNRSuss.hospQLhsuYsuATouAhssALGLNphl...KphsP....LluRLVPFAAVusANslNIPhMRppElp...pGIsVhD-sGpplGpSptAAhhuIupVslSRlhMAhPsMslsPllhppLpKpsahpppPthts....PlQslLsGhsLhhusPluCAlFPQ+ssIpls...pLEPclppplc+..pssPscpVYaNKGL	........................................................aD.sTahGRhpHahplsDP............psl...hho...p...ppLcpA+pl.l..ppa.....+.......t........G........h......s......h......pppp...LWpA+hlh-SshH.P....DTGEhhhh..hRMSs.........lPhs.h.h.ls....u.s...ML..t.....h......................ps....ss.usl.FW.QWhNQSaNAhVNYsN.....Rsu...s...s....P.....h....o..........spp.......l.htu...Y..hsAss.....u.u...susA.....l.G...L....s.ths..........+phsP..........l..lsRhV...P..F.sAV...AuAsslNlshMRtp..Elp................pGIs.V.................h...................D.........c......s...G...........p..............p..............l....G...p.SppA.A.thulspsslSR.lhhshPsM..hl.sPllhph.L...p.+.....t.t.....h...h....p..p...h...s...h.h.t.h...................P.l..phh...ls.....hhs..hh.....hshPhuhu..l..F..PQ..p.......splpss.............pL...E...s..-hptth.t.t.............t.hlhaN+Gl....................................	1	137	197	330
+603	PF00249	Myb_DNA-binding	myb_DNA-binding; 	Myb-like DNA-binding domain	Bateman A, Finn RD	anon	Prosite	Domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.23	0.72	-3.90	194	12500	2012-10-04 14:01:11	2003-04-07 12:59:11	26	179	730	34	6476	17506	196	47.00	26	14.31	CHANGED	+ssWTt-E-phlhphlpphGsp....................WptIupphs.........sRospps+p+Wpshh	............................................+ttWTt-.Ecphll.p..h..l.....p..p...hGpp...........................................................Wp.pI.u...p..p.hs...................sRT.s..pps+p+.apph................................	0	1753	4075	5391
+604	PF02736	Myosin_N		Myosin N-terminal SH3-like domain	Bateman A	anon	Pfam-B_110 (Release 5.5)	Domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	20.70	17.00	20.70	17.30	20.60	16.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.82	0.72	-4.28	41	1520	2009-09-14 13:17:30	2003-04-07 12:59:11	14	67	230	150	754	1364	7	42.00	35	2.67	CHANGED	KptsWV.sDscE..ualpucIp..sppG-pVoVpsts...Gc..pholKcDc	..........KptVWV.sDs+c..ualcu.plp...pc..cGsc.Vs.Vcsts...G+............plsVccDp..................	0	141	253	484
+605	PF00784	MyTH4		MyTH4 domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain in myosin and kinesin tails, present twice in myosin-VIIa, and also present in 3 other myosins.	19.20	19.20	20.20	19.20	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.18	0.71	-4.15	11	1375	2009-09-11 15:02:25	2003-04-07 12:59:11	12	160	222	5	806	1210	7	107.20	31	9.90	CHANGED	ppsh-llppIlppulpp.sLRDElYCQlhKQhscNPs..ppStt+GWcLlhhssusFsPScplhtaLp.pFlpsp.t.......htshAhhs.cpL++ohpsG..sR+hsPuhhElpAhp	.................................p...thhp.ll..phsh.pp....t.L...R..DElYsQlhKQho........p.N.ss.................ppS..t..tR..GWpLLsl.ssu.hFs.P.S.p.p..hht..........aLp.pFlppp..h...t......................................................................t....t....h........Ahh.C..c.pLp...+.o.hp..pG........sR..p.......sPohhElpAh....................................................	1	262	339	583
+606	PF03485	Arg_tRNA_synt_N	N-Arg; 	Arginyl tRNA synthetase N terminal domain	Bateman A	anon	Bateman A	Domain	This domain is found at the amino terminus of Arginyl  tRNA synthetase, also called additional domain 1 (Add-1). It is about 140 residues long and it has been suggested that this domain will be involved in tRNA recognition [1].	21.30	21.30	21.30	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.78	0.72	-3.44	174	5094	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	4796	10	1267	3829	1849	86.10	28	15.38	CHANGED	pplpptlppulpph................th...hlc.h..s.....pp.paGDausNhAhtLAKth+p.......sPpplApplsp...plpts....th......lp..cl-luGP....GFINhhL	.....................................hpphltpslpph................hs.tts.ph..hlc..p....s.......cpspaG.D.....ausNhA..hsLAKhh+p.............sP+plApplsp......pLsts.................sh.......hp.....c.....lEl.AGP...G.FINhhL..................	0	428	821	1065
+607	PF01699	Na_Ca_ex	Na_Ca_Ex; 	Sodium/calcium exchanger protein	Bashton M, Bateman A	anon	Pfam-B_1680 (release 4.1)	Family	This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [2]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [2].  In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [1] see Swiss:Q01728, Swiss:P48768 and Swiss:P70549 respectively.	24.90	24.90	25.00	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.57	0.71	-4.58	111	11392	2009-01-15 18:05:59	2003-04-07 12:59:11	19	59	3066	4	4750	9872	2859	136.70	20	50.60	CHANGED	lhlhhhuchlssshs.slu.p..................hhs....lsstllGlsllAhusuhPEhhsulhushp...............s.......psslulusllGSslhslhlslGlsslhssh...................................htstshthsh.shhhhshhhlhhhhh......................ttplshhpullhlhhYhhalhhh	.................................................h.hlhhhuph.hstshp.tlu.p...................................hhs..............l.sphlh.....Glsll..Ah..G.oS...hP........E.l.h....s.......u.lh..u.s.hp..................................................s..............psclu...lus.......ll....GS....s.l.h......N...l...h.l....l...l.u..ls..s.llsshh....................................................hps.t.s..h..p.h..s...h......sh..h.h..h.s..h.l.hh..h.lhhh.............................................tst.p...l...s.h....h....p....G..h.l...h.l.h..hahhalhh.h.........................................................................	0	1381	2625	3903
+608	PF00999	Na_H_Exchanger		Sodium/hydrogen exchanger family	Finn RD, Bateman A	anon	Pfam-B_312 (release 3.0)	Family	Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus.\	The transmembrane regions M3-M12 share identity with other members of the family.  The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions.  The cytoplasmic region has little similarity throughout the family.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.36	0.70	-5.93	80	17250	2012-10-02 17:06:44	2003-04-07 12:59:11	16	72	4700	5	5319	13718	2497	371.20	18	66.67	CHANGED	hllllh.uhlssh..h.hp+lp...lPs........lluhllsGlllGshshs...........h...............................hhphluplGlshllFhsGlchshpp.lppshts..............slhhulluhlhshhh............Ghhht.h...........h...hshhtulhhGshl.osoussllhtll......-pttlspphuplllutullsDhssllllslhhshh.........shhhshh...............hhhhhhhhhhhshlhhthlhshlhphhpch.......tstplhhhhslhhshhs..shhuchl.GlssllGuahsGlslu...........ptthppp..lppp....lpsht....shhhslFFlhlGlpls.................h...........hthhhhllhhllhlhl.s+hlsshhhtthh...............t.hshppsh...hlu.hshh.+Gthslslsthuhpt......tlhsp..............ph.hshhlhssllosl.....lssh.......lht	........................................................................................................................h..hhhhh.s.h.lhsh.........l..hp+lt........lP...........h..ls...hl......l..s..G...l....l.......l......G....s...h..s..hs................h..ht.s...........................................................................hp.h.h..s...p...lu.l..s.hl...l...F...h............s.G................h.c.h.....s...h......p..p....l..h..p..h..ht...........................................hh..hhu...h.h..t.lhl.sshh.....................................huhhhhh.........................................h..hs.h.s.h.h.t..u..l.h...l.G...s.....hl...u.s......o.....s.s.......ss.l.ht....ll.......................cpt....t....h....s.p.p...h...s...p....h...lh...........utul.....h.s.........Dhsu.ll.h.....h..sh.hhshh.....................tstth.s.h.h..............................................................t.h.h.h..t.h....h.....h..h....h.h.h.....h....l....l....h..t..h...l....h...s.....h....l.....h.t..h.......hhph...............................tsp...ph.h...h...h.h..s..l.h....h..shhs........hh...............h..s........p......h.......l........s............h............S...........s.......h..l..u..s...........h...hu.G.lh..lu.....................ptth.pp..p.......hppp..........................................hp..shh..............hlh.slh.F...l.hl..Gh.tls.......................thl.....................hth.h..h.h....l.l.h....h....h.h........h.l...h..l....s+h...l...ss..h...h..h.h.hhh..................................................................t..hs.h.p..p.t.h.........hhu...hs...hs....pG....t...hu.h..s......l....s....h....h..s...tt.......................th..h.s..t.....................................ph.....h...s...h....h....h....h....s...l....l..l.ohh.h....s..h..h...hh...............................................................................	0	1593	3099	4353
+609	PF02690	Na_Pi_cotrans		Na+/Pi-cotransporter	Bashton M, Bateman A, Haft D	anon	Pfam-B_509 (release 5.5)	Family	This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of  which are also Na+/Pi-cotransporters.  In the kidney the type II renal  Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the  proximal tubule [1].	28.60	28.60	29.20	28.70	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.63	0.71	-4.47	184	5785	2009-09-10 16:47:48	2003-04-07 12:59:11	10	11	2359	0	1241	3956	693	134.10	26	49.88	CHANGED	LhLhG.hphhssGlppssG.sp..l+plLt..phTs...s........htull....sGhhsTullQSSSssol...lsluFVuuGllsltpulullhGANlGTTlTuhllu.............hcl.uthu.hhlhlGsllhhh..pppphpthGthlhGlullFhulphhppu	..............................hhhhu.hphhspuh.p...hts..sp...h.c.p.l.ht....phss.....s.............hhull.......sGhhlTsl.........lQSSoAsss..............lssuhs..u.......s.......G...............l.l.......s.......lptAlsllhGANlGTslTAhlhu..................................................hcl...u.hh...ph.h.h..hl..Gsl.l.hhh....................................h..........................................................................................	0	429	745	997
+610	PF02445	NadA		Quinolinate synthetase A protein	Bateman A	anon	Pfam-B_1915 (release 5.4)	Family	Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid [2]. This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein".	19.00	19.00	20.70	20.60	18.60	17.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.89	0.70	-5.61	144	2787	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	2689	2	795	2280	2221	307.90	41	89.62	CHANGED	hpcIpcLKc-..+sAlILAH.YQpsEl.Q-lADhsG....DSLpLuctAsp.scA-sIVFCGV+FMAEoAKIL.s.P-Kp.........VLlP-h.pAGCshA-hhss-pl....pph+cpa...Ps......tsVVsYlNooAclKA....tuDlsCTSSNAlclVpp.l....sp..cc.IlFhPDcpLGpal..............................tcps.s+cl................................llWs...GhC.VHppassc.clpph+ppa.PsApllsHPEC...s.cVlchAD........hlGSTutllcasppsssp.c.alluTEhGllpcLpc..cs....Ps.Kpahshs.........s.pshCspM+hhTLcclhpsLc......shp.................sc.lpls..c-ltpcAppul-RMLcl	............t.pcIccLh+c..+sAVllAHa.YpcsEI.QplA-hsG..................DSLphA+h.u....sc....psA...ssllhsGV+FMu.ET.A.K.I.L.....o....P-...Kp......................VL...hP.....s.l.p.A.....sCSLs.usss.-ph........................ptap-ta.............P-...............tsVVsYsNTSAAVKA.....cuD.....hssTSSsAl.c.llcp....l.........sp......s...ccIlasPDcaLGpal...................................................................................pcpT..stch...................................lhWp...GtChVH-c.F.psp.plpch+.pp.a....P-.At.llVHPEs.............stsVl.phAD...........hlGSTotlIcts............p....sh...........ss...........p....c.......hIVuT-tGlha+hpp....ts....P.-...Kp..h..lt.ss.......................................................s..sshCPaMthssLpplhps...Lc.....p..tt.......................pElp.VD..ppltppAhhsLpRML-.h................................................................................................	0	274	536	683
+611	PF03822	NAF		NAF domain	Griffiths-Jones SR	anon	PROSITE	Domain	\N	25.00	25.00	26.00	26.00	21.80	24.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.19	0.72	-4.26	71	764	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	57	2	323	696	0	60.30	43	14.83	CHANGED	pPss..lNAF-lI.ShSpGhDLSuLFtccpct....c..sRFsSppsAsslluKlEplAc..shs.apV..+K	..................PtshNAF-lI.S.hSpGhsLSuLF-ccp.p...................pcc......sRFsS.pp...PAspIluKlE-sAc...shu.apVpK.............	0	37	177	261
+612	PF05089	NAGLU		Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain	Moxon SJ, Bateman A	anon	Pfam-B_6295 (release 7.7)	Domain	Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2]. The structure shows that the enzyme is composed of three domains.  This central domain has a tim barrel fold [3].	23.40	23.40	23.70	23.80	20.50	22.50	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.06	0.70	-5.69	30	411	2012-10-03 05:44:19	2003-04-07 12:59:11	7	31	267	5	179	405	16	304.40	38	38.80	CHANGED	RYahNsCTaSYohsaWsWpcWE+cIDWMALpGINhsLAhsGQEulWpcVapchGlocpElcsahoGPAahAWpRMuNlcG.WGGPLspsWhcppttLQ++IlsRMRpLGMpPVLPuFuGaVPpshpchh.PpAplschusWsu......assshaL-P.....pDPlFscluptFlcc.pchY.G.sschYssDsFNEhsPsss...ss............................phLussupulacuhppsDPcAVWl.hQGWhF..p..hWpssthcAhLsuVP.....ps+.hlVLDLauEphP.hWpp..........ocuahGpPaIWChLpNFGGshslaGslptlsssh.pAttps..ssslhGsGhoPEGlcpNslhYELhhEhuWpps.	.......................RYahNhCThuYohsaWsWpcWE+cIDWMALpGlNhsLAhsGpEslWpclhp..c.hGh.opp-l.ppahsGPAahsWtpMuNlpu..W......u..G.....P.Lsp.....sWhppphtL.Q++IlpRM+phGMpPVLPuFuGhVPpsh...............p......c...hh..P..p......splhp..s..pWss........as...ps...h....hLpP..........pD.s...hFtplu.phFhcc.pcha.G....ssphYshDsFpEhtssss......ts.................................lsphupslhpuh.pts.cscAlWl.hQuW.a........W.ps.s.hpuhLpu.V.s.........p.sc.hllLDLa..uEttP.h......app...........ppsahGpPaIaChLpNFGGshshhGphptlspt.......hpAh......tps....sssh........hGhGhs.EGlppN.lhY-Lhh-huWppt.s...................................................	0	64	108	149
+613	PF02365	NAM		No apical meristem (NAM) protein	Bashton M, Bateman A	anon	Pfam-B_530 (release 5.2)	Family	This is a family of no apical meristem (NAM) proteins these are plant development proteins.  Mutations in NAM result in the failure to develop a shoot apical meristem in petunia embryos [2].  NAM is indicated as having a role in determining positions of meristems and primordial [2]. One member of this family NAP (NAC-like, activated by AP3/PI) is encoded by the target genes of the AP3/PI transcriptional activators and functions in the transition between growth by cell division and cell expansion in stamens and petals [1].	21.20	21.20	21.20	21.50	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.25	0.71	-3.95	133	2410	2009-01-15 18:05:59	2003-04-07 12:59:11	10	26	114	15	1319	2332	1	125.10	42	37.77	CHANGED	LPPGFRF+PTDEELlsaYLcpK.ltup............hsh..p................s.Is-l.D....lhch.-P.W-L..P...h.........................hh.s.......tpp..EW..Y....FFs.+-+KYs....s.Gt.........RsNR.u......................Tt.....uGY..WK.ATGp..D+tlhs.............ssth............lGhKKTLVFY....p.......G.+uPcGp....+TsWlMHE.YRL.s	..................................lPPGFR..F.+PT.DEELlhaYLpcK..ltspt..........hsh...p.................h..I.s....-l..D.....lh...+.h...-....P.W-L..P..t...................................thth....scp....EW......YF.Fs..+..-..+...K..Ys.........s...Gs........R.s..NR...u.........................................ss........uGa...W.K...A..T.Gp....D+s..lhs................ssph...................lGhK.K.sLVFY..............p...G..+....u..P...+......G..p........KTsWlMHEYRL.s....................................................................	0	160	722	1039
+614	PF04095	NAPRTase		Nicotinate phosphoribosyltransferase (NAPRTase) family	Wood V, Finn RD, Bateman A	anon	Pfam-B_5038 (release 7.3) & Pfam-B_5422 (Release 7.5)	Family	Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyses the first reaction in  the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase Pfam:PF01729.	19.90	19.90	20.10	20.00	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.66	0.70	-5.09	19	4673	2012-10-03 05:58:16	2003-04-07 12:59:11	11	6	3929	55	1191	3401	285	219.70	27	50.59	CHANGED	aplpDFGsRtt.Shcstthssp...........sthstFhGTuslhh.............stthul.shtppshphhtscpplss...hlpphpp.........suh-hWhttht...hG.sLpDhlshcuhhtths...........hslR.DSGDPhp.................hh-clht+atsh.shcsh.....phtllauDGlshcphhplhcthcs.th...sluFGlGosLhpclsp.h.t....ssslsIshKhhpsptpPlsclS.csstKuh.................hts.....hthl+psFpsst	.........................................................................................lh-FGoRRt.phcstthssp...t..........................uh.h..u.u.hsuTSNlhs......................ucta...u..lsshGTtAHsa........h.......t.....s.....a.....t.....p.h..s.....s....................h.p.s.htp.......................................tsh..sh..hhs...pa.......slt....ulssslps...st.h.t.ph...............................................hhGlRhDS.....GD.sh........................................................................hucc....stphh...-c...h....t.......sh...............................ptpllhSssL.D...pp.l..h..pLhtphsp...............................ssaGlGT.....pLhs.....s.........h.......s..........p..............................h.ss..l.................p..h..s..h......p.h....h.................................s......h.hch.o..pp.tp........................................................................p......................................................................................	0	381	694	967
+615	PF04970	LRAT	NC;	Lecithin retinol acyltransferase	Finn RD	anon	Pfam-B_3758 (release 7.0)	Domain	The full-length members of this family, eg Swiss:P53816, are representatives of a novel class II tumour-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localisation, but not necessary for the enzyme activity [1].  H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyses the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester [2].	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.81	0.71	-4.17	32	808	2012-10-10 12:56:15	2003-04-07 12:59:11	8	10	297	3	418	739	44	120.20	26	54.98	CHANGED	h.......p.GDllpl.R.......hYpHaGIYlGDspVlHhs.......Ps..............t..ssstt...........hhushtptuhVchs.sL-shstGsshhlssh........t.......tptpshss-cllpRAct.LlG....ph.sYsLlhsNCEHFVsaC+aGhsh	......................................................hh.....t.p.GDhl....h...R...........hY.pHaulY..l......G.....c....s.....h......Vl..Hhs...................................................................................hhu..hh..t...p.p.u...hVcts..pLpsh....s..t.u...s.p...h...plssh................................t.................phps...hsscpllp..R.App..hlG..........ph...p.....YsLhts....NCEHFsshs+hGh..t........................................	0	78	152	260
+616	PF04904	NCD1		NAB conserved region 1 (NCD1)	Kerrison ND	anon	Pfam-B_6188 (release 7.6)	Family	Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors [1]. This region consists of the N-terminal NAB conserved region 1, which  interacts with the EGR1 inhibitory domain (R1) [1].  It may also mediate multimerisation.	25.00	25.00	40.20	39.70	21.60	20.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.57	0.72	-4.24	4	175	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	92	0	89	144	0	79.10	79	17.49	CHANGED	hspPoTLuELQLY+VLQRANLLsYYDsFIppGGDDlQQLCEAsEEEFLEIMALVGMAoKPLHVRRhQKALpEWsTsPshFpp	........uLPRTLGELQLYRlLQRANLLSYY-sFIQQ...GGDDVQQLCEAGE..EEFLEIMALVGMAoKPLHVRRLQKALR-WsTNPGLFsQ.....	1	21	29	56
+617	PF04905	NCD2		NAB conserved region 2 (NCD2)	Kerrison ND	anon	Pfam-B_6188 (release 7.6)	Family	Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors [1]. This family consists of NAB conserved region 2, near the C-terminus of the protein.  It is necessary for transcriptional repression by the Nab  proteins [1].  It is also required for transcription activation by Nab  proteins at Nab-activated promoters [2].	25.00	25.00	29.80	25.60	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.02	0.71	-4.45	5	176	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	91	1	93	153	0	152.80	49	30.99	CHANGED	scppsSppshS.PusLGSPtSs...tlusp-ouuss....ssLssstltplsEsuERhu+oLP+uDhuEVscLLKsNKKLAKplGHIlEMS-sDP++EEEIRKYSAIYGRFDSKRR-GKpLTLHE........................LTVNEAAAQLCh+DsALLTRRDELFuLARQVuREsTYpYoh+oSRL+	..........................................................s..tptup.shS..Pus.hGsPtus...............ttsu.........-tL-sthst.VsE.sVERhhtohP+.uDhsElppLLKhNKKLA+..plGHIFEMsDsDspKEEEIRKYSuIYGRFDSKR+-GKpLTLHE........................LTlNEAAAQlCh+Dss..LLTR.RcELFuLARQ.......luREsoYhhoh+so+...............	0	26	34	60
+618	PF03096	Ndr		Ndr family	Mifsud W	anon	Pfam-B_2481 (release 6.4)	Family	This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted [1]. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular  differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21 Swiss:O23969. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases Pfam:PF00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.65	0.70	-5.93	10	725	2012-10-03 11:45:05	2003-04-07 12:59:11	9	5	129	8	272	2897	1291	225.90	42	76.06	CHANGED	EHplcTsaGulpVoVpGs.ct..p+PsllTYHDlGLNHcSCFpsLFsp.EsMsEltc+FslhHVssPGpEpGAsshspsa.aPSl-sLA-plssVLsaFplcoVIGhGsGAGAYILsRFAlpaP-RVpGLVLlNssssAsGWh-WstsKlss..h...GhosslhDhllsHhFu+Etpps....ss-...lVppYRphlscshN.sNLphalpAassR+DLshctssht..........CsslLlVGDpSPah-sVlcsso+LDsppoolLKlscsGGhVpt-QPsKlscuhchFLpGhGahs	...............................................................................p.lcTsaG...lp.V.slh..Gs.c............+PsllTYH.DlG.LN.apoCFp.shF....p.........h..-sM.p.-....lh.pp...F...slhHV....-...A...P..G..p.....p.....G....A.s..s....h..P.....s......a........a...P...o.h..-p..L..A-..l.ssV.Lpa.h...s...h...p...s..l...I.G.h.Gl.GA.G..A.Yl.....L.s.+.F..A...........l..t.a....P.c....h....V.GL..lL.......l.......N............h.....s.......s.........s.....u........t........u......W........h...-......W.........h.............h.....p.........K....l.............................................................G......h...s.....p..s....l........-...h..l........h....t....H....h......F.u...p.p...htt..............p.-.......ll..p..t...a...R...t.....l...t..p....t.......s................N..l....t..h..a....h...p.....u...a..........p........p.....R........p....D....L..p.....p..h...h.h......................s..shll..s...G..s...p....u...P...h.......p..s..s...............l.....c....h....s..s..+...L......s...........p...p.........o......s.h.....l.c..h.t.c.....s.su.....s...pQPtp...lspuhchFlp.GhGhh......................................................................................................................................................................	0	74	119	189
+619	PF03102	NeuB		NeuB family	Mifsud W	anon	Pfam-B_2572 (release 6.4)	Family	NeuB is the prokaryotic N-acetylneuraminic acid (Neu5Ac) synthase. It catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc). This reaction has only been observed in prokaryotes; eukaryotes synthesise the 9-phosphate form, Neu5Ac-9-P, and utilise ManNAc-6-P instead of ManNAc. Such eukaryotic enzymes are not present in this family [1]. This family also contains SpsE spore coat polysaccharide biosynthesis proteins.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-5.23	158	1576	2012-10-03 05:58:16	2003-04-07 12:59:11	9	19	1121	8	447	2406	3908	236.80	36	67.28	CHANGED	lI-sAtc.AGADAlKFQTaps-slsspt..sppsp.....athpp....hssp.o.h-hhcchc.hsh-.appLhcascptGItahSTPFDhpul-hL.pplssstaKIuSuEloshPLlctlAp...psKP.....lIlSTGMuolsEIcpAlssl...........................tpssspplsLLHCsosYPsPh--...lNLpslpsLpptF...s..l.l.GhSDHTh...GhtsslAAlALGAsl..........IEKHFTLD+sh....tGPDHthS..L-PpEhcphVpslRplcpAL.Gsshc	................................................................hlcsAtc.uGADulKaQTaps-shhspt.......s.ps...........a.hpss.......hssp..ohh-h.hcch..c.hsh-.atpL..hcas.c.chGlhhhSoPF.Dhpul-hL..pph......s..sshaKIuSsE...ls.....shP.hlctlAp.....psKP..........lIlSTG.M.u.o.h.p.EI.cpAlphh.....................................pp.t.t..s.psls.l....L....H.......C..s....osY.P.s.s...h..-.-........s.N......LpsltsLpc....tF...s........l.........l........Gh..S....D..Hoh.....G.....h.......t.....s.....sl.....u.....A.....V.A.LG...Ap..l...........I..EKHFTLD+sh....tG.sDp.thS.l-PpEhcphlp.slRpsppAL.Gss........................................................................................................	0	154	297	373
+620	PF02931	Neur_chan_LBD		Neurotransmitter-gated ion-channel ligand binding domain	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family is the extracellular ligand binding domain of these ion channels [1].  This domain forms a pentameric arrangement in the known structure.	25.80	25.80	25.90	25.80	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.64	0.70	-5.19	92	6005	2009-12-16 13:50:00	2003-04-07 12:59:11	18	90	267	651	3245	5129	71	186.70	25	43.27	CHANGED	pp+LlccLhps....YsptlRPs.....pssp.....s.lsVplsltlpplhslsEhsp.hosslalpppWpD.+LpWsstp....asslpplplssc......plWhPDlhLhN.....sssspapso.hpsplhlp.........sGpVhahsss.hhcusC.lclphFPFDpQsCslpFuS............asYss.......pclslphtp............................pphclssFh.supWslhph...shpttp.hs.hsp.........l.aplhl+R+s	......................................................................hhppLhtt......Y.s...t...h...hRPs......................st.........................sh...V....phsl.........lt..p..lhs..l................s.-hs........................hsh..............s......l.ahp...............p....p..............W.......p..........D.......+...Lp..a.s............p................s.s.h...p.t..l...p...l..ssp......................plWhP..Dhhhh..N............p..........t...........s.........t....a.....p....h.....s.............p...p.............h....lhl..h............................sG..p....l.....h......a.....s..............................h.....hh..p...............u.sC....h.c.........l.ph..............FPh.D..t...Q..s......CslphtS........................................a.s..Y.st............pc...lth.h.htp.....................................................pt.h..pl.s..p..a.h......p.......sp.hth....ht....................h...........hs..thst...............h..thhlcRp..............................................................................................	0	1010	1272	2385
+621	PF01436	NHL		NHL repeat	Bateman A	anon	[1]	Repeat	The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies.  It is about 40 residues long and resembles the WD repeat Pfam:PF00400.  The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localised to the repeats [2]. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats [3].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.93	0.73	-7.24	0.73	-3.73	108	7067	2012-10-05 17:30:42	2003-04-07 12:59:11	16	402	688	32	4354	6356	1348	27.90	34	11.21	CHANGED	hstPpulsls..sssplhVsD..ppspplhha	........hptPpGlAls...ssGp..laVuD........psNpRlphh..............	0	2548	3068	3732
+622	PF03031	NIF		NLI interacting factor-like phosphatase	Griffiths-Jones SR	anon	Pfam-B_1405 (release 6.4)	Family	This family contains a number of NLI interacting factor isoforms (eg. Swiss:Q9PTJ8) and also an N-terminal regions of RNA polymerase II CTC phosphatase (Swiss:Q9Y5BO) and FCP1 serine phosphatase (Swiss:Q9PT70). This region has been identified as the minimal phosphatase domain [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.36	0.71	-4.57	120	2877	2012-10-03 04:19:28	2003-04-07 12:59:11	13	63	441	30	1934	3360	347	157.00	26	34.52	CHANGED	hsLVLDLDET...LlHsp.t...................hh..............................hphhlth......RPhlccF...Lp.pl.uph..aElllaTuut..ppYAptllchlD.......s.....pphh...pppl....aR........c...pCh.......hps..h.l..K...DLshl.....................sR.s..........LspllllDssspsahhp.spNul.Ips......ahss.......ps.Dp.........pLhp...LhshL.ctlt..ph.pDVR	................................................................................................sLVLDLDcT..LlHsphp...........................................................................................hth.hlhh.............R..Pt..l..c...pF....Lp..ph...uph..........aE.ll..l.aTu.u.h..............p.t...Y.Ap.......slh.c.h.L.D.....................................s..........pphh.........ptp.l.............hR...................................................c...psh...............................hpu...ph..h.........K...................-L.s.hl.....................................................................sp..s.............h..sps.ll...lDss.s.t.s.ah.hp....s......p...N..u.l..lps.................ahss........................p.Dp.........tLhp......lh.hl.p.l................................................................................................	0	769	1211	1633
+623	PF04923	Ninjurin		Ninjurin 	Finn RD	anon	Pfam-B_5824 (release 7.6)	Family	Ninjurin (nerve injury-induced protein) is involved in nerve regeneration and in the formation and function in some tissues [1].	20.70	20.70	20.80	20.70	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.29	0.72	-4.30	50	257	2009-11-15 17:29:03	2003-04-07 12:59:11	7	5	73	0	176	264	1	98.90	39	59.48	CHANGED	shNpYss+KolApuhhDlALLoA..NAsQ.....L+hllphspp...tthYhhh.lsLlslSllLQlllullllhhup...hslppt..................................ppppp.hpphNshsshh.............................lhllsllNllIouFs	............shNpYusKKolApuMlDlALLhA..NAsQ...........L+hllp.Gsp...htaYhsh.lsLIolSllLQlhlGlLLlhlup......hslpp...................................tcpt+.hshlNNhsshhlFllsllNlhIouFs........................................	0	55	71	132
+624	PF02613	Nitrate_red_del		Nitrate reductase delta subunit	Bashton M, Bateman A	anon	COG2180	Family	This family is the delta subunit of the nitrate reductase enzyme, The delta subunit is not part of the nitrate reductase enzyme but is most likely needed for assembly of the multi-subunit enzyme complex [1].  In the absence of the delta subunit the core alpha beta enzyme complex is unstable [1].  The delta subunit is essential for enzyme activity in vivo and in vitro [1].  The nitrate reductase enzyme, EC:1.7.99.4 catalyse the conversion of nitrite to nitrate via the reduction of an acceptor.\	\	   The nitrate reductase enzyme is composed of three subunits [1].\	   Nitrate is the most widely used alternative electron acceptor after oxygen [1]. This family also now contains the family TorD, a family of cytoplasmic chaperone proteins; like many prokaryotic molybdoenzymes, the TMAO reductase (TorA) of Escherichia coli requires the insertion of a bis(molybdopterin guanine dinucleotide) molybdenum (bis(MGD)Mo) cofactor in its catalytic site to be active and translocated to the periplasm. The TorD chaperone increases apoTorA activation up to four-fold, allowing maturation of most of the apoprotein.   Therefore TorD is involved in the first step of TorA maturation to make it competent to receive the cofactor [2].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.73	0.71	-4.34	270	4923	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	2034	17	709	2437	138	149.30	21	69.62	CHANGED	shhshht.h.shst..........................tpt....ltthhp..thtppshtplpt-YspLF........hsPasShYLs.......sc.......hhGpshhclpphhpptGlphss....pEssDHlulhLEhhuhL..................sphttthphlpp+Lt......sWhsth..htpl	..............................................................................hhh.........t..s.t............................................tttLt.shhp.......phts..t.sh..h....p..lp....scaspLF.............................t.s.hsS..halp...........................pc........hG.p...s....h...h.....cl+t.....hhp.ptGl.ph..s..s..........pE.........s....DHlslhL-hhuhL..t......................tht..................pphps.htphlstpLh...................sWsshF...h...h....................................................	0	194	410	579
+625	PF00877	NLPC_P60		NlpC/P60 family	Bateman A	anon	Pfam-B_292 (release 3.0) & Pfam-B_9022 (Release 8.0)	Family	The function of this domain is unknown. It is found in several lipoproteins.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.67	0.72	-4.22	28	11783	2012-10-10 12:56:15	2003-04-07 12:59:11	14	163	3617	17	2263	9076	1767	106.80	30	35.28	CHANGED	Gp.PYtaGGsssp.............GFDCSGhsphsatph.GlpLPRsuspp.................hthupp..lstsphpsGDLlFFps....tssssHVGlYl................Gssphl+us..usslp..........hsslpssaWppphhtstR	......................................................................GpPY.h.aG....Gs.s.sp...................................GhDCSGhs......p...h.s........ap.......p....t.....G......l...p.....L...P..R.s.stpQ......................................................h.p.h..Gp...t.............l...s....h....s....p....h...psG....D...L.lF.Fps..................ttsssHVGIY..l........................G..s.s...p.h...l..Hus.......upslp.............hs.s..h..t..p.s.h.att.h............................................................................	0	699	1509	1928
+626	PF04981	NMD3		NMD3 family 	Bateman A	anon	COG1499	Family	The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway [1].	22.80	22.80	22.80	23.10	22.20	22.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.82	0.70	-5.25	73	560	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	451	0	390	543	91	215.30	34	49.77	CHANGED	CspCGt...shcss.s................s...hCscChhpph.clsc.lscph...plthCppCsphhps.spWhps..tuc-lhslh.p.l.cs.l..........pcsh..hh-sphlhsEs...........pupclcl+lslps..plhs...s.lppshtlphhlptptCscCp+ht..sshacAlVQlRpp..........h.pchshhhl-phhh+tsttt.lsplpctc-.GlDhahuspstAp+hschlpsth.ssphpcotcLlup-tp.upp.Y+hTauV+l	............................CspCGs...sh..s.s.s..su...................s...hChsCl+ppl..DIoc..sls+p.s...........slphC+pCp+a......hps....sp..........Wlpst....ES+ELLslCL++l.csL...........scs+......llDAtFlWTEP..............................HS+Rl+l+lolpt.........Elhs....ssllpQsh..V-ahlptp.CscCp+h........stshWcAsVQlRQ+...........s.cK+ThhaLEQLll.K.tstpppslpIp.c.hc-.GlDFaaus+...spAp+hl-Flpshh..Ps+h.pp.SpcLlSpDhcssphsY+hTaSVcl.....................	0	138	235	327
+627	PF01234	NNMT_PNMT_TEMT		NNMT/PNMT/TEMT family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.75	0.70	-5.42	7	264	2012-10-10 17:06:42	2003-04-07 12:59:11	12	4	72	91	177	297	5	229.70	31	93.18	CHANGED	h-u..shhuspsahp+FsPcsYLpsaYph.Stsss..tp..llhahL.s....lhpphs.sthts-sLlDIGuGPTlYphLuhp-shc-IhloDasspNhpELt+WlccE.usaDWosslpahsplEG.....stsphp-hEpKhRttV+p..VLcsDVppsssl..su........s.lP..sDsVlohhslEsuCssLssYppAl+shsuLL+PGGaLlhhssLctohY.hGt+c.Fosl.LpcEhl.cAlhcuGhplpphp.....t..ttshhstcGlhhlsA+K	............................................................t..........t.h..pcFpPpsYLpp.Yt.....spt.........tt...............hh...a.hLpp....lhphF..s....s...tl....p.G.c..pL..lDlGuGP.TlY.p.lLSAschFc-IhhoDas-pNhpELp+W.L.............cc-..suua..D..Woshhpa.l.s.p.lEG......ptpp.hpE.+cccLR.ptlKp.....ll.sDV.ppspPl..ss............lP.....sDsl.l....oshCLEsss.s..hs.s..YppALcpl......ssLL+PGGaLlh...hs.s.....Lp.t...o........hY..hs...Gt.......p.c...asslslsc-.lcpAlt..cu..Ga.pl.php...........p.....t.sh.s.pu.hhhhhupK...................................................................	0	60	72	135
+628	PF04147	Nop14		Nop14-like family 	Wood V, Finn RD	anon	Pfam-B_8521 (release 7.3);	Family	Emg1 and Nop14 are novel proteins whose interaction is  required for the maturation of the 18S rRNA and for 40S  ribosome production [1].	34.90	34.90	44.20	35.60	34.40	34.30	hmmbuild  -o /dev/null HMM SEED	840	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.42	0.70	-6.62	37	404	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	278	0	286	416	7	609.40	24	92.83	CHANGED	s+tp+ppsltt..........IccphNPF-h+ss..+sKa-l......hG+p.scssp...ucPGlo+uhup-pR+pTLhtEhpp+sKsGuhlD+RFGEp.DsshosEEKhhpRFs+E+Q+p...+K...cshFNLp-DD-p...................LTHhGpoLu..........pD-.p-tcht...t..................pt.chtt........pp....tpspPp..R+KSKpEVMcElIAKSKhaKtERQpt+-csp-hp-cLDcs..hp-lhshL..psspp..t..........................ht...........spcph.c-YDptl+pLs..a-+RupPsDRTKT-EEhAcEEtc+L+cLEp-RL+RMpG...tsps-cppcpt......................ts-Dl-Ds.........................tahhs.s.pppspcp.........................................................uhps---tppD-D.p....t.pp.p.........pt..ptts-.Esptppcpt.......................................tspspsplsaTassPpoa--hhphlp..shshp-hssllpRItts..a+PpLttsNKpKLspFhul....Llp+lhaLusps.............shpllpslhphl+sLucp.....................aPpshupshRshlcch.pphct....slps.........s-LlhlslluslFsTSD+aH.VlTPuhlhluchLupsthp...olpDlupGhalsslhLpYpphSKRalPEllsFltssLhhh.............hPpcspp..........................s.sh..shpt.sstLp.......lsss...................pt..thpspp..Lphhclh........spppssph+lslLsshlsllppsss.lapsp...suahElhpPhhslLpphsp..................tsh.splpphhpc.lsphhststht..R+PLsLppH+PluI+ohtPKF.E-sFsP.c+Kp.YDss+ERsEhsKLKtphK+E+KGAhRElRKDspFlARp+lcEppccDpEYccKh++llsplpspEGcp	...............................................................................................t..............t.NsF-hphs.....t...Khph..............hst......t............t.ss...hs+t.u.ppRppsh...cht....p.t+..s.hhhD+R..h........G..E..s.p..h........s.E-+hhtRathEp.pt.......p+.....tshasLp-p-...........................................................LTHhGpsLt..............................t...-p.tpt.............................................t...htt...................................ttt.t....p.+o+pElhpElIsKSK...Khc+ptt+cp..t.p.htpLDpt..htpl.t.h...tt..t.................................................................................................................................................tt...ptYD.hh+..phh..h..-..h.+u.tss-RhKotEE.ht......tcp..tp+LppLE.............tpRhpRM.u......ppptp..t.t...................................-s.tct.............................................................h..t.........................................................................................t.t.tp.pp...tps...........................pt.t....................................tp...pt.........................................................................................................................ttthshsh..hPp......sh.pp.....h.thht...th........tp..........hhlp+l..th...pspLt.tN+t+ht.h..h....Llpah....hhpt..........................hth.h....p.lh..lhphsp.................................................s...hstthp.hltph.tp..t......................................t.LhhhphhuhlassSDhh.H.VhTPshlhh.......sphLtp..............h.h......shtphs.uhhlstlhhp.h.t...upRhhPEhh.ah.thlhhh......................h.t..........................................t......h......................l..t.................................................h.h..h...............t.phthl..hhthlpth....hhtt.....uh...hh...s.h..hlpth.....................................hpthhpt....htt...h.p.t.........ht...L....h..........p.p...p+...............shslt.......h.P+h.....p..s...hp..t..........c.......s.sp......p..ct....-h.t+hh..tphKcEhKus..h+ElR+DstFhtp.phpp.htpptthppKhtplhs.lttpptt................................................................................................................................	0	105	165	243
+629	PF04153	NOT2_3_5	NOT; 	NOT2 / NOT3 / NOT5 family	Bateman A	anon	Pfam-B_2131 (release 7.3)	Family	NOT1, NOT2, NOT3, NOT4 and NOT5 form a nuclear complex that negatively regulates the basal and activated transcription of many genes. This family includes NOT2, NOT3 and NOT5.	20.50	20.50	21.10	21.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.04	0.71	-4.28	66	799	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	308	0	526	782	7	125.90	31	23.73	CHANGED	lpsuhsss.pst...ss.pp..pap........Ppshh.......spps.........................phhp..phst-.....TLFalFYhh.s..shtQhhAApELppRsWRaHKchpsWhpR....t.....c.hs........sph...Ep...GsYhaFDhps...........Wpphc..c....sFphcYphL-	...................................................................sshts..tst...ss.....t..t...pap......Pps.h........h.spps.sh.............................................thhp..+h.sp-.....TLFalFYhh.u..............shhQhlAApEL.t...p........+sWRaH+chphWhpR..pt..p....pshs................................sph..Ep...GoY.haFDhpp............Wpphp..p.pFphcYphLp................................................................	0	187	299	442
+630	PF04065	Not3		Not1 N-terminal domain, CCR4-Not complex component 	Wood V, Finn RD	anon	Pfam-B_8081 (release 7.3);	Family	\N	25.80	25.80	25.80	31.30	25.50	25.70	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.69	0.70	-5.09	24	389	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	268	0	251	374	2	217.20	45	32.76	CHANGED	Mup.RKLQQElD+shKKVsEGlptF-sIY-Klps..ssNsoQ+.....EKLEuDLK+EIKKLQRhRDQIKoWhuss-IK.DKss..Lh-pR+hIEs......tME+FKulEKthKTKuaSpEGLp..sss......pl.DPc-pc+p-sspalssplDELpcQlEphEuEh-pl.sthKKt.ptst.spppchp-hcpthERacaHls+LEhlLRhLpNspl-s-pVp-Ic-DIcYYVEsNp-..sDFh.Es....-slYD-.Lsl-pp	.............spRKLQ...tEID+shKKVsEGlptF-sIapKlps.......ssNssQK.........EKhEs...........DLK+EIKKLQ.....RhRDQIKoWh...uus-IK...D........K..p...............Ll-....pR+.hIEs...........pME+FKsVE+EsKTKAaSKEG..Lu....tup.................................+l..D....P...tp.....+cKpEsspaLsssl-pLptQ.l-phEuElEsLps......p.......t.......+..Kt.....pts......p.....s..........c.....ppRlpclcphl-RH+aHlppLEhlL.RhLcNs.p.l.ps..-pl.p.c.lK-slcYYl-.....s......s...p-.....sD..F..Es.............-tlYD-LsLp..........................................................................	0	87	147	217
+631	PF03060	NMO	NPD;	Nitronate monooxygenase	Griffiths-Jones SR, Bateman A	anon	Pfam-B_2634 (release 6.4)	Domain	Nitronate monooxygenase (NMO), formerly referred to as 2-nitropropane dioxygenase (NPD) (EC:1.13.11.32), is an FMN-dependent enzyme that uses molecular oxygen to oxidize (anionic) alkyl nitronates and, in the case of the enzyme from Neurospora crassa, (neutral) nitroalkanes to the corresponding carbonyl compounds and nitrite. Previously classified as 2-nitropropane dioxygenase [1,2,3], but it is now recognized that this was the result of the slow ionization of nitroalkanes to their nitronate (anionic) forms [4]. The enzymes from the fungus Neurospora crassa and the yeast Williopsis saturnus var. mrakii (formerly classified as Hansenula mrakii) contain non-covalently bound FMN as the cofactor. Active towards linear alkyl nitronates of lengths between 2 and 6 carbon atoms and, with lower activity, towards propyl-2-nitronate. The enzyme from N. crassa can also utilize neutral nitroalkanes, but with lower activity. One atom of oxygen is incorporated into the carbonyl group of the aldehyde product. The reaction appears to involve the formation of an enzyme-bound nitronate radical and an a-peroxynitroethane species, which then decomposes, either in the active site of the enzyme or after release, to acetaldehyde and nitrite.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.86	0.70	-5.29	12	5886	2012-10-03 05:58:16	2003-04-07 12:59:11	10	43	3071	11	1913	12559	6372	309.60	26	84.17	CHANGED	psthschh.hp.slhtshhuh.hssscLAuAVSpAGGLGllu..uuhhos........DtLtpplptlcphTsc.PaGlNlhlsp.ttsc....................h...h.phthchuls...................................lluhuhGsP.tphlccl+puGshlhshsuosppActstpsG.......sDsllsQGhEAGGHpG......csu....thhhLlsplscsls.......lPVlAAGGItDs+slAAALsLGApGVthGTtaLsopEussssht+pthlpustccThhopshs.........G+stRsLpsshhcch-.....p..shshs.t.................................hsts....lptusspu...shctu.hhsGQstthlsclhsscpllpplsp-	..........................................................................................................................................................................................................................................................thh.thchP.l.l.p.u.....sM.uh.....l...u...ss.......cL.su.A..Vup.A.G....GL.Ghl.u.....u...u.t.h.ss...........................c..l.....c.....p.....p.l...p......t........h............+...........p......h.........s.......s.........p.....P............a.....u...l...N...l..h..h......t.......htt......................................................................................hp...h...hh.p.tsht..........................................................................................................................................................l..l...s...h.......u.......h.......G...............P................t.......p.......h..........h......p........t......h......+........p..........s......G........l.......h..........l......l.....s.......h.......l.....s....o.....s.....c..t....A...p....t....h..t....c....h.G..................................s.D.u....l....l.....s.......p..............G.....h.............E.......A...G..G.HhG.......................phs........................sh..s..L..l...s..p...l......s..s..s.hs....................................lP..Vl..A.AGG.I..s...s........G........c.u......l....s......A...A......h...........s...........L.......G.....A........s........uV....p....h............GT....t..F..l..so..p...E........u....s...s........p.t.......sa....K..p..t..l....l....p................u........p.........t.....p......D.........s......s..l.o..t.t.hs................G....h.s..s.......R.sl..p...s..p.....h..h.p..p.h.t...........t......t..h.t....h.........t.t........................................................................................hh.tt.........lpt.s..hhps........c..h..c....h.s........h.h.sG.pss...t..h.....l.....p...c..h...sstcllpplh..t.................................................................................................................................................................................................................	1	550	1189	1608
+632	PF05021	NPL4		NPL4 family	Wood V, Bateman A	anon	Pfam-B_13681 (release 7.6)	Family	The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome [1]. Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.	21.10	21.10	21.30	21.50	19.60	20.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.92	0.70	-5.26	36	376	2012-10-10 14:49:21	2003-04-07 12:59:11	10	22	298	0	260	392	4	274.70	36	51.89	CHANGED	RhGaLYGpYccaspsPLGIKAVV-AIYEPPQ.psE.DGlsl.hs...pppppVDplApth..GLp+VGhIFTDLhsss.tpGoshhpRchcoaaLSuhEllhAA+hQhpaPp.s+aS...psGpFuSpFVTCllSG..s..suplshpuYQVSspAhuLV+ucllpsosp....Pshhhlpc........sspp..cYlP-VaYpchspYGtpVpc.A+P.FPl-aLlVslocuaPpsPp..........shF........psssFPlENRphhGp.........QshpsltcaLpsp...............sshhpplSsFHLLlaltph.thLs..pp-hthLscssp....pp..t.h.th.tpstsatsLlpIlp	...............................................RhGaLYGpYppap...p.h...PLGl+..AhVtAIYEPPQ......sp.-..u.lpl...hp........tptptVDplA..pth............GLp+...VGhIFTDLhs....ts.......t......t......GpVhhpR......p.h-oaa..LSu.EslhAuchQspaPp.s..+hu...........sGp.FuSpFVTsl..loG...s..t.s.s.plphpuYQlSs..pshtlV+sshltsstc.....Pplhhlpc................................sspt...pYlP...-........V....aYpc.h.s....c.a.G..t.p..lpp.A+P...hPV-YLlVs.....lstuh.PpsPh...........hF........ppssFPl.ENRphhGp..........sQshpsLtphLpptt...........................tp.hhctlSDFHL.LlaLh.p..t..h..hs..p...........cchshLhcssp........pcs...t.....h.ph.hts.tWtpl..l...........................................	0	96	146	219
+633	PF01909	NTP_transf_2	DUF76;	Nucleotidyltransferase domain	Bateman A	anon	[1]	Family	Members of this family belong to a large family of nucleotidyltransferases [1]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.40	0.72	-3.66	117	8895	2012-10-02 22:47:23	2003-04-07 12:59:11	18	121	3228	80	3285	7676	1203	100.00	15	25.51	CHANGED	lppltctlpphh......stplhlaGShsc.....Gphp.t.....SDlDlllhhspt.....................................hhhthtthhpphhshthDlh..............hhtthp.........hhhtphhppthhh	..........................................h.......h..t.h..........hhtl.h.laGShuc............G.p.h.pst........SDlDlllhhspt...........................................................................................h..th..t.....h...t.....h........h.....h..shh...................................................hh...........................................................................................................................................................................................	0	1095	2088	2757
+634	PF01759	NTR		UNC-6/NTR/C345C module	Bateman A	anon	[1]	Family	Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in [1]. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs).  The TIMPs are classified as a separate family in Pfam (Pfam:PF00965) [2]. This expanded domain family has been named as the NTR module [2].	21.90	21.90	21.90	21.90	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.74	0.72	-4.50	103	1259	2012-10-01 21:39:20	2003-04-07 12:59:11	16	55	160	51	605	1076	0	105.20	21	14.37	CHANGED	pc..hCps......-Ysh+spVhs.....hppps......shsthshpltpVhK....pu......th.ppsppthahtpt.....pC.phht...Gp.pYLlMGpt.........pptphphllsppohlchW.sptppphpchpp	...........................t.phCts......-a....s....l...ps+lhp..................h.ppps............shhph....s.s.p.l.p..plhK...............................pu..........ph.pcspp.p...hhh.pt........pCsplps..........sppYLlMG......................pptpsphlls.pohlthW.sphtpphpp....................................................................	0	82	136	315
+635	PF04142	Nuc_sug_transp		Nucleotide-sugar transporter	Bateman A	anon	Pfam-B_2311 (release 7.3)	Family	This family of membrane proteins transport nucleotide sugars from the cytoplasm into golgi vesicles.  Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.56	0.70	-5.27	10	1158	2012-10-02 19:55:49	2003-04-07 12:59:11	10	22	276	0	767	1530	427	213.10	26	58.73	CHANGED	+hscpL+ctlhsps...tDoLKluVPShlYslQNNLhYVALSNL-AATYQVTYQLKILTTAlFoVlhLsR+LuphQWhSLlLLhsGVAlVQhssssu.p.ssspss...........................................spN...hlGhsAVLsAChsSGFAGVYFEKILKsos...sSlWlRNlQLuhhGlhhuLls..salpDtspIs-pG.........FFhGYshhVWhlVlLpAhGGLllAlVlKYADNILKuFAoSloIILSoluShh.LF.DFplohhFhLGAhlV	................................................................................................................hh..................p....hh.h....u.l.P.u..hl....Y.sl.p.N.sLh.a.l....u.......l.s...l..s..su.s.....a.Q.l.hhp.h.......K......Il.......sT.A..lhshh....hLp+p..Ls.h..........h.Q..W..h.uLh.l.L.h.h.G..lsl..l.p....hs.....s.st..s........................t.....t...........h.......................................................................................................................................tp.......hh....G...h......hhl...l....h...us....hhS..uh...A..u..............VY.............hEt..l...L.K..p..p.t.....................s.l....a...h..p....N.......h......l.....h..huhhhs.h..hh...............hh...h.......t....h....t........h.......p..tG..............................................h..h..G....a....s....h.....s.h..h.hl.h................p.u.h..s....Glh.huh....h..h..+ass.sl..h..Ksassshuh...lhss.hh.S.hh.hh...s...h...s........hhhs..................................................................................................................................................	0	334	453	632
+637	PF04096	Nucleoporin2		Nucleoporin autopeptidase	Wood V, Finn RD, Rawlings N	anon	Pfam-B_5132 (release 7.3);	Family	\N	21.90	21.90	23.80	24.90	21.80	21.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.80	0.71	-4.37	57	473	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	294	19	304	507	1	137.20	35	10.65	CHANGED	sYahpPolppLpphohpcLpp...VpsFslGR.csaGpIpF...tsVDLssls.L-..............plVphps.+pltV.Ys-s...p..KP.lGpGLNlsApITL.sshPh...s+sspt.h.pspp.....hpcplcplpp.tpsscFlSY-s.sGsWsFcVpHF	...................sYas.PSh--Ltphstpc....hpp......V..s.sFslGR.cuYGplpF...tsVDLs.s.l.s..LD.................p.....IV.phpp..+.....plhV.YsD-..................sp..KPPl..GpGLNh.AplTLcssaPh..........s+ss+p.hpp.spc.h.....acp+lc+lpc.p.psscFl.s.Ycsp....o.....GsWsFcVpHF................................	2	113	182	263
+638	PF01733	Nucleoside_tran		Nucleoside transporter	Bashton M, Bateman A	anon	Pfam-B_2135 (release 4.1)	Family	This is a family of nucleoside transporters. In mammalian cells nucleoside transporters transport nucleoside across the plasma membrane and are essential for nucleotide synthesis via the salvage pathways for cells that lack their own de novo synthesis pathways [2]. Also in this family is mouse and human nucleolar protein HNP36 Swiss:Q14542 a protein of unknown function; although it has been hypothesised to be a plasma membrane nucleoside transporter [2].	22.90	22.90	23.10	23.10	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.89	0.70	-5.26	7	1065	2012-10-03 03:33:39	2003-04-07 12:59:11	13	12	303	1	710	1041	14	251.30	21	65.30	CHANGED	hhtlslINu.hsAlhQsSlaGlAushPtpYosslhsGQuluGhhsolshl.lshAsssc....hptuAhhYF...hsuhlllllChlhh.hlphhcaY+hatphp.....................p.pt-hhpsccp...sp.s...stsshpp.............s..t.....h..hhsllppl.shshslshhaplslshFPuh.o..h.os....s....pp.aa..lssFLsFNlFDhlG+slsuhhhaPs...ssRhlshhshhRhlFlPLFhhCshtsp...+....hPshFcp-hhFhhhhhhFuhoNGYLsSLsMhhuP+pV..sccpEsAGtlhshFLslGLuhGulhSalhch	.............................................................................................................................................h....hh.h.sh....ssuh...hpsu.h.huhsu...hs.....p.a........hpshh.Gp.uhuG...................hh.......s.u.hh..l.....h.s.h...h......hsp.................................pt.s....shhaF...hhuh.hh....h...hs...h....hh.h...h.h.h......h............h....ht....h.h...t.............................................................................................................................................................................................................h.h.lh.......pphh.....h...h....hsl.hhhahlT...h.lFPu.....h..............h.....t......s...........................s................................h....h...........h............h...h....hhhaNhhDhhG........+.....h..s.t.........h..........h....................p..p..h.l.h..h.h...sh.hR.hl.h..l.Phhhhs..h..t....................................hh.t..ps.....hhh.....h.h.h...hhhuhoNGahsshshhh...u......P............p.....h...s........tpt.........phu..G.hhsh....hl....h..hGlhhGuhhuhh...h...................................................................	1	294	433	600
+639	PF04880	NUDE_C		NUDE protein, C-terminal conserved region	Mifsud W	anon	Pfam-B_6501 (release 7.6)	Family	This family represents the C-terminal conserved region of the NUDE proteins. NUDE proteins are involved in nuclear migration [1].	27.20	27.20	28.20	28.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.15	0.71	-3.89	3	274	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	162	6	163	251	0	178.10	37	42.72	CHANGED	SLEDFEp+LNQAlERNALLEhEl....DEKESLplclQRL+DEsRDLKQEL.hVpER.ppsNRKSRPoP...........V.susSlPo...TPss...psShsSP....+SlPNGhVoSPL..TPss+lSL................pLAu..ssA+DsAsspStTSuSVN.shshsSshsh.ptSussSFssRu....h.ss.PphsQuHSRspS	...........SLEDFEp+LNQAIERNAhLEsEL....DE.KEsLhlplQRLKDEsR.............DL+QEL.tVp............c+.........p....c....h....s....p.p.....s...tsos......................................l.p.ssh..olPu.............T.Pss.........ps..sh.sos..............................puh..s...suhu..u....oPL....TP..s..s.+...l.Su........................................plAu...shsps..us...ts..h...sss.hp..........h....t..........s............s..............s............................................................................................................................................	0	39	64	109
+640	PF00293	NUDIX	mutT; 	NUDIX domain	Bateman A, Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.73	0.71	-4.52	197	43912	2012-10-02 00:00:35	2003-04-07 12:59:11	23	282	5206	325	11753	31604	9218	130.90	17	65.32	CHANGED	hthusssllhspps..................clLlhcctps.................................................shaphPuGtl-..GEs.tp..................................uAhREltEEsGlph.......t.hthhthhthttsstt.....................................thhhhahsphtsst.thp.t.t.........Ehtphpahshpclhphhhthp.......hhtthhtt	.................................................................................................................................................h....shh.h.l.hptpt..................clL.l..h....c..ctp.t.................................................................................................s.h.a.p.h.P.u....G....t.l.....-.......u...E..o.......tp...........................................................us.hR.El..t.E..E..s..Glph.........................p.hph..h..s.....h.....h...t....h.....h...stt...................................................................................h.h..h...h....a..h....s....p....h..........t.....s...t..............h..t..t.t.......................Eh.t.p....h..t....a..h....s..hp.ph..p.h........................thh..........................................................................................................................................	0	3648	7193	9734
+641	PF03826	OAR		OAR domain	Griffiths-Jones SR	anon	PROSITE	Domain	\N	20.10	20.10	20.10	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.38	0.72	-6.56	0.72	-4.31	45	968	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	131	0	530	872	1	20.70	51	6.33	CHANGED	s-.+soSIAsLRhK...AKEHsss	......sp+soSIAuLRhK...AKcHus......	0	82	133	288
+642	PF03137	OATP	OATP_C;	Organic Anion Transporter Polypeptide (OATP) family	Mifsud W, Bateman A	anon	Pfam-B_626 (release 6.5)	Family	This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. [1] initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins (e.g. Swiss:Q92959) are also considered to be OATP family members. In addition, the methotrexate transporter OATK (Swiss:P70502) is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted.  Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null --hand HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.72	0.70	-6.46	16	1462	2012-10-03 03:33:39	2003-04-07 12:59:11	15	17	98	1	852	1674	81	439.80	25	82.67	CHANGED	hKhFllshslshhsQ.shssuahsSslToIE+RFplsSspoGlIsusa-IushllllhVSYFGu+hHRPRhIGhGsllhulGullhuLPHFhhs...................Ypaspss.sssspstsspLC.........t....p.stsstsspcptpshhallhhhuQhlpGIGsoPlhslGlSYlDD.scppp.SPlYlulhhshshhGPAlGalLuShhhplYlDhspss.t....lplsssDPRWlGAWWLGFLlsuulslloulPhFhFP+pLPcs.......................th....thpt.pspcpppppsppscstt........................................tpl+cF.pslhplLpNslahhhllupshpssshsGhhoFlPKaLEpQauhouupAshLhGslslPssulGhhlGGhll++a+lsspuhsthshhssllshhhhlshhhlsCssssluGlsssh............ss.tt.s.hssCspsCsCspstasPVCussGhtahu...........................shsusssssstsstp.spshssssssssspss..........tGhCsss..CspphhhalhlhshsshhsshutssshhllLRsVp.--KohAlGlphhhhRlLGhIPuPIhFGhlIDssClhW.uppC.Gp+GuChhYDssshp	.....................................................................................................................................hhhhhshh.h.......p....hh...s.hh.ssl..o.p..l.E+Ra...tl.S.t.sG.......hlsus...-l..u...shhhhhhlo.Ya..G.s..+..h..p.+P.phluh.G..........shlhuhushlhslPcFh....t............................................................................................................hp.ht.................................t.....t.......ht.....................................................................t.t...t......t............................h.h.hhhhhuphlhGhGtssl.slGhsYlD-...spp...pp.us.hY.....l.u..hh.s..hthhGPhhGah.l.uu.hh.hp...ha...h.......-.................t.l.s..p.c....s..pWlGA...W.Wh.....Ga..ll.suhhh...h.h...uhs.hhhh..P.+p...hstt...............................................................................................................t.............t....................................t...........................................................................................................................................h..p.th....s..hh..p...lhp.N....hahhhhh..sth....h....h...h.....h..uh.........hsF..........h.sK...al..E.........p.Q....a.........t...............s...........su............us.........hh.......h...G...h.....h.ls...sh..s.......h.GhhhGG.h...lh.p+...h....p.h..t..h..h....t...hh..t..h...shh.ht.h.h.......shhh.....h..hhhhtC........s.........h.u....G.ls.sh................................t.....s.Cs.ts.s..t..tshsh.ssh......................................................................................................................................................................................................................G..C.ts........t..t....h....a.hh.h...h..h.....h.hh.h.h.....s.ths........h....h..h....hl...R.........sl..p..+shulGh.thhhhR.h..h....u................hlPuPlhaGhhlDpsChhW...t..........p.......s....t...p.u....sChhYs...h......................................................................................................................	0	328	378	620
+644	PF05005	Ocnus		Janus/Ocnus family (Ocnus)	Moxon SJ	anon	Pfam-B_4799 (release 7.6)	Family	This family is comprised of the Ocnus, Janus-A and Janus-B proteins. These proteins have been found to be testes specific in Drosophila melanogaster [1]. 	20.20	20.20	20.20	23.60	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.43	0.72	-4.17	22	220	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	116	7	113	230	6	104.80	40	67.16	CHANGED	Lst.lPpV-lD.cGh.FKYlLlpltspt.....scts+.lVRGhstspaHs...DIa-clptphcphGl..ssc......................CLGGGRIc+csppKp..I+VYGaSpuaG+A...cHphopclLp..spYscY.pI	..................................................................Lht.lPpVcI-.pGh.aKYlLlplpsts..........spts+.lVRGht...s.c....aHs...DIa-clp....tchc....p.h.Gh..ssc.......................CLGGGRIpHpspcKp..I+VYGhSpua...G+A...cHshop-lLp..spYs.-Ypl.............................................	1	44	56	89
+645	PF00215	OMPdecase		Orotidine 5'-phosphate decarboxylase / HUMPS family	Finn RD, Bateman A	anon	Prosite	Domain	This family includes Orotidine 5'-phosphate decarboxylase enzymes EC:4.1.1.23 that are involved in the final step of pyrimidine biosynthesis. The family also includes enzymes such as hexulose-6-phosphate synthase. This family appears to be distantly related to Pfam:PF00834.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.61	0.70	-4.95	87	7126	2012-10-03 05:58:16	2003-04-07 12:59:11	19	18	4753	429	1546	4780	3008	216.50	23	86.65	CHANGED	spLpluLDhtst..............cchl...plscclss..lshlKsshslhpshG........hpllptl+pp.s..hhlhhDhKhsDIGsTstpthp.....hhphsAchlslpshsG..sslpuhhcsupphs.....................................................................................................tllhls.hoshsthshtp........hspthlcpttctp.t.............hh.Ghlsssp.s............................chhhlsPGlph............ttusstutphtts.thht.ttuchllVGRuIhtus.sPttsucph	..........................................................................................................................lhlAL..D..hpsh.......................................pps.h.............p.h.l.c..p....ls........s...ts....s....h.l.K..lGhthhhs.G.........................phl.c.tL.+.pts.............hhlhhDh.K............ht.DI.s.sTssptst.......................................................s......p........h.........u.......s........Dhlslpssu......G....hph....hcuuhcs..h.pphs.................................................................................................................................................................t.l.l.t.ls..hh..oshstp.phpp..hs..............tss..p...th.s.pp.h.tchttp.......................................t...Ghlsuspps......................................shhhls..P..Glp...................................psu.ss.s.s....pt..h...hhs..t.......s.t..............ss.......h.lllGRsIspAs...sPht.shct.h.....................................................................................................................	0	478	961	1295
+647	PF04084	ORC2		Origin recognition complex subunit 2 	Wood V, Finn RD	anon	Pfam-B_7065 (release 7.3);	Family	All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex.  The function of ORC is reviewed in [1]. 	19.60	19.60	20.10	20.00	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.09	0.70	-5.60	31	329	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	276	0	239	313	5	306.80	30	59.16	CHANGED	SspoLuplt......shlspccahphhpph.pth...pppphptL.chapph..............FtpWhh-LppGFsllhYGlGSKcpLLppFspphLss......................hshlVlNGa.Pslsh+sllpsIsphlh.t.............thhsppstcplphlhchhpst...................psclhlllHNlDGsh..LRppcsQshLupLushspIallAShDHlsuPLlWD........................ptct.ppaNFlaa-sTTatPYstEh..saps.sl..hh..............................................s.....+osp.....hutpuhpaVLpSLTtNu+sla+lLlphQLp.....................sptss.....pthGl-acsLappCpcpFlsSsEhshRohLsEFhDHKhlppp+sssGhE...............hLhlPhspspl	.......................................................Stpshtph....hlspp.phhphh.pp...h..t.....p.pchptL.p..a..p.p...............FspWhhpLpp.GFslllYGhGSK+pLLp...cFtpphhpp..................................................shlVlNG.ah.P.s...lsl+s...lLssIsptlhst...............................................tthhpps.ptlphlhphhppps...............................................................shplhllIHNlDush........LRp....s.ps.QphLupL....u..s.......hsp......IpllAShDHlN.sPL.lWD............................pspt...spaNalaa-sTTatPY............s.tEh....sats..pl..hl..............................................t........pssp.........hshpuhtaVLpSLT.Nu+sla+lLhphQLp.................................................sttss.....phhGlpapslYppspEpFlsoS-hslRs.LpEFhDHpllpp++.s.s.sGs.E................hLhlPhstt..h..................................................	1	83	134	198
+648	PF03392	OS-D		Insect pheromone-binding family, A10/OS-D	Mifsud W	anon	Pfam-B_3032 (release 6.6)	Family	\N	25.00	25.00	25.40	26.20	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.33	0.72	-4.01	91	701	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	96	9	258	733	0	92.40	40	73.06	CHANGED	YTsKYDNlDlDEILps-RLlpsYhpCLl-cG..tC.TP-GcELKchLPDALcTsCuKCo-KQKpuscKVlpaLhcp+P-.WcpLpsKYDPcspYpc+Y	........................YosKaD..s.l.sl--ILpscRLlpsYhcCLLcc..G...C.TP.-............G+-LK.....ch.l.....P-ALc.s.pCsKCo-+Q+psucKllcaLhpp+P-.W.ppLtsKYDPpspYtp+a....................	0	61	101	246
+649	PF04756	OST3_OST6		OST3 / OST6 family	Wood V, Bateman A	anon	Wood V	Family	The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs [1]. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation [2].	21.30	21.30	22.50	22.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.01	0.71	-4.67	19	672	2012-10-03 14:45:55	2003-04-07 12:59:11	8	15	309	3	385	597	4	142.80	26	50.64	CHANGED	hhh.Fh..hhclsph+lhhPs.lshP.hhlshhllllo............................aFlhsuGhhashIpssPhlspshcs.....psVsFh.tpsptQahhEuhhsuhlashsul....Ghlhlsps...stshs+p................chhhhu..Ghshllh.FhshhhF	.................................................h.ah..hhp..h........clh+Ps.h.shs.hh..h...sh.hl..s..l...l.u.........h..h.h..t............h....hh........p..+.hWhhhslhh.hhhhsSGhhashI+....tPPhstpsscs.....t.lsahts.pspsQ..ashE..shhsuh...la.shhuh....uhl.lL.s...p.......ss.........t...s..hsct...................c.hhhhh.....Gh.shlhh...Fh.h...h..........................................................................	0	117	190	292
+650	PF01010	Oxidored_q1_C	oxidored_q1_C; 	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus	Bateman A	anon	Pfam-B_41 (release 3.0)	Family	This sub-family represents a carboxyl terminal extension of Pfam:PF00361. It includes subunit 5 from chloroplasts, and bacterial subunit L.  This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.63	0.70	-4.86	113	14159	2009-09-12 05:40:05	2003-04-07 12:59:11	14	14	12076	0	124	13554	281	225.10	56	42.75	CHANGED	RIYLLTFEGHLs......laFpNYSG...p..+sssh..Y....SISLWG..K.cs.....Kt..ls+N...hhL.t............psscpsSF...Fs...K..phY..pl.........s.pN.l+phh..p...s.Fhsh.s..pF..ss..Kp..sh......YPaESDNTMLFPLLlLlLFTLFlGhIGI.P....Fs..Qtth.....slDILSKWLsP..SIN..................LL..HpNsss..S......h..DWYEFlp...NAlFSVSIAhFGIFIA.hLYpPlYSShpNhsLINSF..lK..hss..K.R..hhh..DKIlNsIYsW..SYNRGYIDsFYsphhotGIRtLAcLTpFFD	........................................RIYLLTFEGHLN.VHF..QNYSG......p...Kssuh..Y....SIS..L..WG........K..ct..sKt........lN+s....hhLhs..................ps..s..p......p......sS...F...FS..........p.......ch.Y.....p..I..............s..pN...s....R.....s.hh.....p........s..F..h..s......l...s......pF.....s.s.....Kp....sa....................sYPa..ES..DNTMLFPlLlLlLFTLFl......G.sI......GI..P...........F...s...Q...t..s..h.......-l..D..IL.SKWL..T.P..SI.N..........................LL........Hp..s...S...N..s....S......h....DW..Y.....E.F.....l..p.s..A..l..F..S..V..S.....I..AhF..G.IFIA...hLYpPl.Y..S..S.h....QNL..s...........L...l..NSF.........lK......t.uPK...R.........hhh...D+.I..h...NhI.Y.sW..SYNRGYIDs.FYsp.hhh..Gl.RtLuc.hh.pFFD.........................................................	0	38	87	111
+651	PF01483	P_proprotein	P; 	Proprotein convertase P-domain	Bateman A	anon	[1]	Family	A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain.	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.02	0.72	-4.20	75	1577	2012-10-03 19:46:52	2003-04-07 12:59:11	15	112	646	15	726	1507	250	87.90	31	11.11	CHANGED	lEaVplplslsHs.pRGDLplpLsSPsGspShLhs.pRsp.........D.tpsGahsWsFh......osptWGEsspGsWpLcl..pD.......................sstpppG......plpsWpLtl	.......................lEcVplpl.s.lsHs..pRGDLplpLhSP.s..GT.p.oh..Lhs..pcst...................................D...s.ps..G..h....h.sa.sFh........................................osphaGE....s.s...p.G...s...WpLcl...p.D..................................ps.stptG......plppWpLhh..................................	0	252	371	555
+652	PF04062	P21-Arc		ARP2/3 complex ARPC3 (21 kDa) subunit	Wood V, Finn RD	anon	Pfam-B_6413 (release 7.3);	Family	The seven component ARP2/3 actin-organising complex is involved in actin assembly and function.	25.00	25.00	40.00	40.00	18.30	16.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.01	0.71	-4.49	29	364	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	276	15	231	331	3	170.20	48	94.42	CHANGED	MPAYHSsFhs-st........phl..G..NhulLPL+TpaRGPA.................ssspshDIlDEsLsLFRANsFF+NFEIKusADRlLIYhhLaIo-CLpKL.....ptshstp-ApKtLhsLAl-.sFsIPG-sGFP..LNuhYphP.ps+s-uElLRsYLpQlRQELuhRLlc+lYs..sp.p................spPSKWWLsFsKRKFMsKSL	....................................MPAYHSth.s.t............phl..G..NhulLPl+..Tp.h....+....GPA.h................................ss.pchDIlDEslhhF+ANlFF+NaEIK.u.ADRsLIYlhLaIo-CLpKL.....pt.ssopspupKthhsLuls.pFsI.PG-s..GFP..LNuhYthP..ts+p.-...s...............-hhRpYLp.....QlRQEhuh.RLhc..+.Va..s..sp..s..................spPSKWWhsFsKR+FMsKSL............................................	0	73	121	183
+653	PF02331	P35		Apoptosis preventing protein	Mian N, Bateman A	anon	Pfam-B_13247 (release 5.2)	Domain	This viral protein functions to block the host apoptotic response  caused by infection by the virus. The apoptosis preventing protein (or early 35kD protein, P35) acts by blocking caspase protease  activity.	20.10	20.10	21.20	27.20	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-12.01	0.70	-5.30	7	25	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	14	10	0	29	0	301.10	58	92.61	CHANGED	MCVlhPs.hcssQTlIhDst...spphR-LlYlNplh....ss.lsKsVLMhFNISGPl+sVsR.hsspht-hhKSKlD......cpFsphp+sh.....SsphsGhc...+YFcs-cYoVsC.stsshKsKatKhLpscshs-ccsIEsacK.CL.P.......Lhsc..........psshYV..sVCsLKPuhtNs.uppsLSFpYpP.ssKVIVPhtHEIs-sG..hYcYDVh...AhVcuVp.....phcc.lQsLhh.pta.cs.c.lhascsshNcphhhhs.-FpTcshasKs....hpI.CNu.I.DccpchLhVKL+NVTspLscsl................ILsplc	...........MCVIFPVEIDVSQTVIRDCp..VDc.QTRELVYINKIM....NTQLTKPVLMMFNISGPIRSV.TR.KNN-LRDRIKSKVD......EQFDQLER-Y.....SDchDGFHDsIpYFKDEHY..SVSCQ......NGSVLKSKFAKILKSHDYTDKK.SIEsYEKYCL.Pp......LVDc..........+sDsYV..AVCVLKPGFENG.SNQVLSFEYNPIGNKVIVPFAHEIN.DTG..LYEYDVl...AYVDsVpFD.GpQFEEFVQpLILPSoFpcSEKVLYYNEASKNKNMIYKALEFTTESsWsK.SpKaNWKIFCNGFIYDKKSKsLYVKLHNVTSsLNKNV................ILshIK.......................................	0	0	0	0
+654	PF02225	PA		PA domain	Bateman A, Mahon P	anon	Pfam-B_259 (release 5.2)	Family	The PA (Protease associated) domain is found as an insert domain in diverse proteases. The PA domain is also found in a plant vacuolar sorting receptor Swiss:O22925 and members of the RZF family Swiss:O43567. It has been suggested that this domain forms a lid-like structure that covers the active site in active proteases, and is involved in protein recognition in vacuolar sorting receptors [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.23	0.72	-4.32	69	5065	2009-01-15 18:05:59	2003-04-07 12:59:11	17	204	1352	75	2693	4930	531	99.80	17	13.82	CHANGED	sstsstptsll................................tsstssssshtsssspGpl..lls.....pputs...............sh....hp+s....ttAp..ps.GAtulllhs.....................shststhtshslPsshl.spssGptlhphh	..................................................................h........................................................t.........t..t....tp..h..t.....s.h...s..l....p.G..K...I......sll...............pcG...s.s...................................sa..............spKs...............ppAp....ps...GA..hull.lhs.......................................t....st.............s...p.....s.h...t...l...P.shhl...s.ttuttlht..................................................................	0	704	1487	2130
+656	PF00291	PALP	S_T_dehydratase; 	Pyridoxal-phosphate dependent enzyme	Bateman A, Finn RD	anon	Bateman A	Family	Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16 Swiss:P04968, tryptophan synthase beta chain EC:4.2.1.20 Swiss:P00932, threonine synthase EC:4.2.99.2 Swiss:P04990, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22 Swiss:P35520, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4 Swiss:P76316.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.14	0.70	-5.19	148	31175	2009-09-12 08:45:30	2003-04-07 12:59:11	20	102	5380	356	8492	23404	13882	295.50	21	77.75	CHANGED	lp.thstTPLhph...................pla.hKhEshp..s.sG..ShKsRsu...hhhltp..........s.p............................ptl...lsuouGN......................................puhulAhsus..th.G..lp.s....hlhl.....Pps.sst..............t+hthhcthGA...pllhhstt.t.t.stst....phsp...t......h..h.hpt.................................ssstshtGhtohuh..El...............h....pph.........................p.h............llsss.GsG.GhhsGlupshpp..........ts.c..l.luVps..pss.....sshhpthtttt...................................................hht.ulshsh........................ssth.hthhcph...............h.....sVs-p-shp.uhptlsppp............G.lhs..tsuuussluus.ht......h.........t.tp..ll.hl.lsu	......................................................h....ht.TPLhh..........................h.tt.h.h.ss....p.la..h...........KhEs.......hp....s...sG.........S.......h.K.sRsu.........hthltt...................A.tpt......................................................................................st....psl..........lp.so...u......GN.............................................pG.h.u.l...A..h.s.us......th..G.........hc.s............hlhM.................Pps...hst.......................+htt...h.c.t..h.G.A.........c.l....l..h...s..s.........s...s......s.........t..h..h..s..t.st........ph.s....p....ph.......h.t...hp...................................................................................ts.s..s.h.t....tp...t..s...hu........El...............................................h...........ppht..............................tt.D.h..................................llssl...G....s.G..G..shs..G....l...u.t.hhpp.....................................sl..cl..lul-s........pss..........................s.sh.....h...t.s..h.t..s.s.p.........................................................................p......tht....Glshsh.......................................................................................sssh..s.hp.h..h..c.c.h..t............................hh....sl.s-p-....shp..shct....l....t....p....pc.....................G....l.ls.....s.s..u..u.us...u...l...sus...h.....p.h.t.t.p............................tspp...ll.hl.hs...............................................................................................................	0	2689	5306	7156
+657	PF00024	PAN_1	apple; Apple;PAN; 	PAN domain	Bateman A	anon	Patthy L	Domain	The PAN domain [1] contains a conserved core of three disulphide bridges.  In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.64	0.72	-4.22	89	2217	2012-10-02 11:41:37	2003-04-07 12:59:11	21	217	255	64	1525	2546	76	80.20	16	20.08	CHANGED	C..........atthtstthts......tshpth.ts....sshppCtptCt.....pptp.........Cpuasapts.....................pppChLpspspts.......................spltt.....stshshapp.pC	............................................th.h.s.......shpth...ts..........ohppCtptCt.....pptp.............C.puas..apsp.......................pppChLpspspts........................................th...............h..h...........................................................	0	624	791	1265
+658	PF01569	PAP2		PAP2 superfamily	Bashton M, Bateman A	anon	Pfam-B_486 (release 4.0)	Family	This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases [1,2] that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.46	142	14398	2012-10-02 00:53:37	2003-04-07 12:59:11	16	88	4426	44	4448	11648	1667	132.00	19	47.04	CHANGED	thhhhhhshhh.............shhl....s.h........h....Khhhs..p..sR...Phhhhtth..h.....................................................uF...PSGHs...shuhshhhhlhhhhtphhhh...................................................hhhhhhshhluhuRlhhuhHahsDllsG....hhlGhhhsh.....hhhhhhtthth	...........................................................................................................................................................................................................................hhh....hhhshhh........shhl...........s.h..............h..........Kth.ht....c.......sR......Ph....h.h.h..h..h..h....hh...........................................................................................................................................SF.......PS..GHs...........s.h.u.h..s....h....s..h....h...h....h....h..h...h..t.th.h.th.......................................................................................................................................hhh..h..h.u....h.h.luh..S.R.l.....hh.G.h.Ha.sDl..lsG.....hhlGhh.hshhhhh.......hh......................................................................................................................	0	1276	2479	3559
+659	PF03828	PAP_assoc		Cid1 family poly A polymerase	Griffiths-Jones SR, Wood V, Mistry J	anon	PROSITE	Family	This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity [1][2][3][4]. Proteins in this family have been located to both the nucleus and the cytoplasm.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.09	0.72	-4.02	112	1402	2009-01-15 18:05:59	2003-04-07 12:59:11	14	49	312	22	919	1373	27	60.60	28	8.69	CHANGED	sLGpLLhpFFcaYu.p............pFsapphsIul....ps.uth....hsK.pphthh.......................t.thlsIpDPhsssp	...........sLGpLL.hpFFcaYu..................cFsapcpsISl....+p..uth........ls+.pp.t.t.ht..............................................................phlsIE.....DPhp.s.................................................................	0	290	439	704
+660	PF04928	PAP_central		Poly(A) polymerase central domain	Wood V, Bateman A	anon	Pfam-B_1341 (release 7.6)	Domain	The central domain of Poly(A) polymerase shares structural similarity with the allosteric activity domain of ribonucleotide reductase R1, which comprises a four-helix bundle and a three-stranded mixed beta- sheet. Even though the two enzymes bind ATP, the ATP-recognition motifs are different.	20.50	20.50	20.60	20.90	20.10	20.40	hmmbuild  -o /dev/null --hand HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.59	0.70	-5.57	36	745	2009-01-15 18:05:59	2003-04-07 12:59:11	12	32	320	11	465	707	14	304.90	37	49.06	CHANGED	pppa.....GlT.PlSts.Psst-hphoppLhctLpptssaEop-.-sp+RppVLppLppllp-aV.ppluhp+shspphspssuuplasaGSY+LGVhusuuDIDslslsPpplp+........pcFFssFhchLpppsplscltsVt-AaVPlIKhpasGIplDLlFApLslsplPc..sl.sltDcslL....+slD-pslRSLNGsRVsDpILcLVPsh....csF+hsLR.slKLWAp+RulYuNlhGF.GGVuWAlLVARlCQLYPNAssus...llp+FFplaspWpWPp....P.........VlLpphpcs.......hthp..VWsP+h...spD+hHlMPIITPAYPshsuT+NVopSThpllhpEhpRuhcIspclh.........hsp..tsWpcLaEth	.........................................................................................................................................................hGho.slShs.Pp..-h.hsppL.p.Lp..sha.Espp.....Ehp+..............R..........lLt.pLp.p...llpcal.pplutp+shstthhttssutlhshGohplulhs.suDlsslslssphh.......................................................................................................................................................................................ppaFt.hhphht.t.plpclpsV.cAaVPlhchpasGlplDllaAplsl.plP..p...sl..clp...sc..s..lL.....csL...D..ps.lR.SL..N.GsRV..sDpI.Lc..LV.Psh.............psFRhsLR.slKhWA+.+.............Rul..YSNhhGFhGGVsWAhLVA.RsC...Q.............L.Y....P.N....A.....s.sus....................lVp+FFhla.sp..WpW....Pp..................P........................................VhLpt..-css..........Lth...VWsP+h.....................pD+.......hHhMPIITPAY.Pp.NuoaNVo...hSThplh............hcEhpp..G..htlspcl...............sp....tpWspLFp..............................................................................	0	142	239	368
+661	PF05028	PARG_cat	PARG; 	Poly (ADP-ribose) glycohydrolase (PARG)	Moxon SJ	anon	Pfam-B_5996 (release 7.6)	Family	Poly(ADP-ribose) glycohydrolase (PARG), is a ubiquitously expressed exo-  and endoglycohydrolase which mediates oxidative and excitotoxic neuronal death [1].	20.80	20.80	21.40	21.10	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.14	0.70	-5.20	23	357	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	168	8	240	364	7	279.40	30	52.28	CHANGED	asc.h...p..ct..Fhp.h............LP..ths+lsLplsslh.t..............sl.lLtpppspplhlopcplusLLAsuFFshhspp.................ttt.sphPsh.NFspLap....s.ptpsphpKlKClhpYFcpls.......pphssGhVoFpRhth................t.pphs.WppsstsLp....plclhscutIEDp..tshLpVDFANKalGGGVLspGsVQEEIRFhIsPELlluhLFscshccsEAlhIhGApRaSsYTGYusoFpa......................pGpa.Dpp.shDphpR........+pTpIVAIDAlpa.......pshhp..QacpstlhRElsKAasGFh...ptptpspphs...................................................................sluTGNWGCGuFuGDscLKslIQhlAsS...................tspRshl.YhTFGDppLpshhp	.......................................................................................................................................................................................................h.............ht...h............hs.hhphh...hph..h.h.................................................h.hl.....t...s..t.l...hop...husLlupsFhshh..t.............................ph...h.sF.sph..ht......t......tt.........pKlpslhpYFppht............tph.psh..lshp..Rp.h......................................................p.....ht..ppt.h.ht.....hph.............ps.....h......IE..pp.........th.lpVDFANch...lGG.Gsh.s.t.G.hl.Q............EEIhFhhsPELl.luh.Lh..hp.......hppsE.slhlhG..spp...a...SpapGYu.p.oapa..............................tt.p..h..ctt.....h....c..t....htc...........htspllAlDAhph...........t.t...p....Qat.ptl.RElpK..A.....h.s.G.Fh.............t..t..hs...........................................................................................................................................slu..TGpWGCGs..F.s.Gc.pLKhllQhhAuu....................s..t.+s.hh.Yhsatp..th.....hh...................................................................................................	0	114	147	209
+662	PF01734	Patatin		Patatin-like phospholipase	Bashton M, Bateman A, Dlakic M	anon	Pfam-B_2206 (release 4.1)	Family	This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of  the total soluble protein in potato tubers [2]. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids [2]. Members of this family have been found also in vertebrates.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.36	0.71	-4.40	116	10726	2012-10-02 11:19:24	2003-04-07 12:59:11	17	127	3394	5	3812	8861	1395	181.80	20	39.60	CHANGED	LslsGGGs+.G....hhphGslpt....L..................................tththphchlsGoSsGulsu...................................................hhhshs...hs.pphhpthtphhtpthhshh..................................................................................hhhthhtttshhssphhtphlp......ph.......................lsptthpphttththh.............................................................................h.ht.tttthhhhttptts......stplhp..............................slh...ASs..uhPshh....................................tshph........ssp.......ha..........hDGG......lh.ss....hPh.phsh	.............................................................................................................LsLsG.G.Gs+...G.....hhp.hGllcs................L.........................................................................................tp...tsh.h...c..h..l..sGoSs..Gul.su...........................................................................................................................................................u.hh..s.ss.............s..s..t....t.....h...h...th.h.t.....p.h...ht.p.hh.ht.h....................................................................................................................................................h.........h..h......t....t....s....h....h....p.....s...p...h....h.t..ph.lp..........................ph.....................................................h.s..t..t..t.h.p.p.h.h.t.....hhhh..................................................................................................................................................................................................t....t..s.....h..h....t..h.t...h..h.h.s...............................p.t.p.l.h.p...........................................................................................................s.lt.............ASs...............ulPsha............................................................sh..ph........................................sup..................................................hh.............................................................lDGG.........lh..ss...hPht...h.......................................................................................................................................................................................................................................	0	1192	2259	3131
+663	PF02460	Patched		Patched family	Bateman A	anon	Pfam-B_2400 (release 5.4)	Family	The transmembrane protein Patched Swiss:P18502 is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	800	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.61	0.70	-13.13	0.70	-6.63	9	2194	2012-10-02 18:57:54	2003-04-07 12:59:11	13	37	648	0	1317	3841	1223	372.80	15	51.82	CHANGED	hhs.chhahhs.sDhp.shtphtshspp.shs.pcahsucuhststa..hhlsupspss.......lLp.shLs-lhplschlhpsh.......................tl.pss....h.hsacclC.pa.phspsspphh..................lhpp.ps...pthslTYPhhphhsptlYlusphuGVphhs.......................ssplp.s+shhLhahschsscpscphuppaEppLtpalcpp.ssp..hlphshhpsphls-Elp+suhshhPhhslohhlLhsFohlssh..h.p...........lppKPhlAhhGllsshhAhlouhGhLhhhGh.assIssVhPFLlL.uIGVDDhFlhlsAWc+Tstpps...........hccRhucslsEuGsuIoITShTslloFulGshTshPulplFChhsulAlhFsalYQlTFauAlhulsschEhptppsh..h.......hs....p................pphpspsuh.....................................................t.upphpp..hhs.....chhhshYssFlhssps+lhslhlallYlsluhYGshshcpsLsPspLlhs-S.Llchhp.h-chlaptGttlplhVpNPPslsh.spshcchpphhscFEshsashGtpuTpaWLp-Ypp.h.p......php.hpspc..................h..hsthcpalthsttsh.Wtpshhhs......cssstlppFhFplu..hcshsshss+s+hhpphRslAcpas...FNVolFcp.thasDQh.plhssslpshlhsllsMhlVshlFIsp..sshslshulsSIslGVhGhhShWGlsLDPloMlsllMSIGFSVDaoAHIuYtahpsttp....sspcRlhsALpslGWPlhpuuhSTlLslhsLhhVsoYhlhlFhKTlhLVlslGhlHGLhhLPllLshhss	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..................................h.......t....h.....................a................................a..h..-..t..h.............h...............h..........h....h.s.h....h....h...h.h.h...l..s....h..h.h..h....................p...h.....s.......sh.h.........h..h..h.s..l...h....h...........h.....t...h...............h...G...h.......h..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..........................................................................................................................................................................................	0	483	664	1096
+664	PF02170	PAZ	ZAP;	PAZ domain	Bateman A, Song JJ	anon	Bateman A	Family	This domain is named PAZ after the proteins Piwi  Argonaut and Zwille. This domain is found in two families of proteins that are involved in post-transcriptional gene silencing. These are the Piwi family and the Dicer family, that includes the Carpel factory protein. The function of the domains is unknown but has been suggested to mediate complex formation between proteins of the Piwi and Dicer families by hetero-dimerisation. The three-dimensional structure of this domain has been solved [2-4]. The PAZ domain is composed of two subdomains. One subdomain is similar to the OB fold, albeit with a different topology. The OB-fold is well known as a single-stranded nucleic acid binding fold. The second subdomain is composed of a beta-hairpin followed by an alpha-helix. The PAZ domains shows low-affinity nucleic acid binding and appears to interact with the 3' ends of single-stranded regions of RNA in the cleft between the two subdomains. PAZ can bind the characteristic two-base 3' overhangs of siRNAs, indicating that although PAZ may not be a primary nucleic acid binding site in Dicer or RISC, it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.	23.30	23.30	23.40	23.40	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.61	0.71	-4.86	55	1915	2009-09-11 14:14:06	2003-04-07 12:59:11	17	66	319	37	1147	1880	5	132.50	21	13.63	CHANGED	tsll-..hhtphhpppptpt.p.ppp........hpcsltGlhVhspaps........+pa+lsslshcssspppFphp...........spphohs-Ya+ppYslplphs.p.Phlhsppppp................................................saLP.ELCplsshpchhppphsh..pshhh+tpsps	.....................................................................................................................................hpctlp...G..hh.V.s.p...aps................+pa..p.lssl....sh..p.................s........s..p.p.....pF.hp...............................spphohh..cYapp+..Y..s..l...pl...p...hs..p.PhL..p.sspppc...........................................................................................saLP..E...l..C..p..l..s....s.......hp.chhpchtph...hshhh+hp.................................................	0	337	545	909
+665	PF00564	PB1	OPR;	PB1 domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.68	0.72	-4.32	53	2276	2012-10-03 10:59:06	2003-04-07 12:59:11	19	126	339	38	1408	2199	10	83.30	18	13.97	CHANGED	shplKhpatssht+........hphspsh.sap-Lhptltpththt........tshplpY.Dc-t.-hlslssDcDLppslcphct............t.t.pl+lhlhss	........................................................thKhpats.phht.........hths...t...s....h..sap....cLhpplpphhsh......................tsh...plpY...........h...D...-..-...s...-........h.ls.lss-pD...Lppul.phhpt.............................lplhl...t..........................................	0	348	710	1054
+666	PF00786	PBD		P21-Rho-binding domain	SMART	anon	Alignment kindly provided by SMART	Domain	Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.09	0.72	-3.55	44	1824	2009-01-15 18:05:59	2003-04-07 12:59:11	23	43	302	22	1078	1667	2	56.30	28	11.27	CHANGED	tISsP.ssacHhsHVGaDspsG.hh.....GhPppWppllpss..........hsppc.tppspsshpshtahs	............tISsP..os.F....c.Hs.sHV..Ga.D.st.s.Gths........................GhPtpatp.llpps..................................hpp.p...p..t..h.......t......................................................................................................................	0	294	490	775
+667	PF01161	PBP		Phosphatidylethanolamine-binding protein	Finn RD, Bateman A	anon	Prosite & Pfam-B_5394 (Release 7.5)	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.37	0.71	-4.35	128	4705	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	2779	40	1522	3605	238	145.50	26	74.89	CHANGED	sshlshpa..............hp.Gssl..sPsh...hpsh..Pp..........................ssp..s.asllhh..............................DPDA.....................htsah.HWl......lsNIP....................................s..pshssh...................up.............................hsYhGPsPP.Gss.hHRYhFhlauhss................sh.ptssst...sp..htpsh.................ppa...Lsps.lsus..ahp	.................................................................................................t...h..pa..........t.htsG.ssl.......oPph...hssh..Pt.................................ssc....t.as.lshh..............................DPDA..Ps...........................tpsahHW..l..........Vss.IP....t..t...lsts........................................uhh..ps..t.s.sh............Gp..............................ssYtGssPP...........G.............pt..hHR..YhFh..lauhss..............ph..sl...stssst....s....hthth...........................ptpt..Lups.lsuha.............................................................................	1	420	841	1251
+668	PF01399	PCI		PCI domain	Bateman A	anon	[1]	Family	This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [1].	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.03	0.72	-3.72	77	4727	2012-10-04 14:01:11	2003-04-07 12:59:11	22	54	409	7	3184	4579	40	109.70	16	22.45	CHANGED	.shtpllpshppss.hppatphlpph.................................tthhtp.hhtt...........hhppLhpplhcpslhplhp.......applshppluptlplss.....................splEphlsphIhsstlp.upIDph....sthlhhpc	....................................................................................................................................................hhplhps.ht.psp.hpt.h.tp..h.l.p..ph........................................................tt.h.h.t..p...h..hhp...........................hh.p.p.Lh.p...plhpps.lt.p.hhp............................sappl.s.lsplupt...l.p.lss....................................pclEph.ls.phI.tsst....l.p..u..plD.ph.sthlhht.t.................................	1	1114	1760	2604
+669	PF03462	PCRF		PCRF domain	Dlakic M	anon	Dlakic M	Domain	This domain is found in peptide chain release factors.	20.80	20.80	21.00	20.80	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.45	0.71	-4.39	100	9136	2012-10-03 10:28:09	2003-04-07 12:59:11	13	15	4731	15	2219	6114	4472	113.30	38	32.37	CHANGED	c...htppsDt-...ht..p.hppElpplp.pplpplcpc......hsh..sth..Dp.pssllEI+uG..sGGsEAs....aAp.LhRMYh+aA-.p.+........uacscllc..hstu-h.u.......GlKpsslplp.........Gc..........tAYuhLKhE	..............................................th....ttsDt-.ht..c...s..pp..El.pp.l........c.p.c.lpp.lE..c........L..l.p...........cst..Ds.....pssh.lEI+u........G...........uG..GsEAs....aAu.LhRMYpRaA....E....p.+..................Ga+sEll-.......hs.tu-h..u....................GhKplshplp.............Gc...........sAYGhLKhE..................................	0	757	1443	1875
+670	PF02153	PDH		Prephenate dehydrogenase	Bateman A	anon	PSI-BLAST P20692/1-290	Family	Members of this family are prephenate dehydrogenases EC:1.3.1.12 involved in tyrosine biosynthesis.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.53	0.70	-5.50	10	4258	2012-10-10 17:06:42	2003-04-07 12:59:11	12	22	4077	29	1083	3244	2767	243.70	25	69.28	CHANGED	lAhuL++pG.tsplhGhDhsstpsttAhcLGlhDssss..lptsp-A..DlllLAVPlcsstclLcclus.tlccusllTDluSVKscllcshcphls.phtpaluGHPMAGoctsGstuucssLF-spshlLTPspc.Tssptlppl+cllcthGA+lllhsPccHDpssulVSHLPHllAhuLsstht..chpsshc.sh+hAuuGFRDhT....RIAuusPhhWpcIhhpNscslh-tl-catpclsclpphlc....spDt-...sLhchh+p	..............................................................................pl..h...shs...p........t.t..h....t......u......t.......s...h..h..p...t.......h.......t...t......h............p.....h....l.....t....p.A..............-.llllus.P..l.p.t....s...p.h....l...p...c...l.......ss...........l......t.......t.....s.s.........ll.....sD.l.u.SsKs.s.l.l.p.t..h....t....p...h...h......s............................s............phl..u.u..HP....M.s.Gsp........s..G.....s..u.ps.sL.a.p.st..h.hl.ls............ss.........c............t.......s.........s.................p....s.......h....p....h....l...t.p...h.h...p...s.h.G.A.+.lh.p.h.s.s.p.-HDpshAhl...S...HLPH..ll....u...hulstt.ht..........pp.s....t....p..h..p.......h.....hp....h.....u....u..s....u....F....R..-....ho.....R....lA....u....s....s.P...p.h...ap...-Ihhs..Npp.llphlcpa..tppl.sphhp.hlp..........psD.t.p...thhphht.p....................................................................................................................................................	0	337	710	930
+671	PF04166	PdxA		Pyridoxal phosphate biosynthetic protein PdxA	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	In Escherichia coli the coenzyme pyridoxal 5'-phosphate is synthesised  de novo by a pathway that is thought to involve the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, catalysed by  the enzymes PdxA and PdxJ, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate [1].	19.70	19.70	19.70	19.70	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.99	0.70	-5.21	16	2867	2012-10-02 21:08:39	2003-04-07 12:59:11	7	6	2310	19	692	2198	2820	293.60	39	88.25	CHANGED	h..tpc..hpp.s.phVllu-tshL..ppttthhshp.l.........slcchp.....s..p..shh.hlt.hsL.th......s.sh........h.GcssstsGthslchLscAsphshsGphsullTuPlsKsslppA....Gh.asG+TEaLA-......hss......sc.....pslMML.ssp......cLRlsLlTsHlPL+-VssslTtctltphlcllpcsLppcaGItpP+IuVsGLNPHAGEsGhhGpEEh-pIh.....................Pul-phR..tpGlslh.....G.....PlPADTlFpts........tttth...DAVLuMYHDQGLhslKhhuF.spuVNlTLGLPalRTSsDHGTAaDlAGpG.hAcssShhsAlchAs	......................................................................ttt.......h.phllhu-hplL....p.p.t.s....th.l....s..ls....l..................................p.lps.hp......st.....s..p..........t.........s.s.hh....sl....h...s.h...tt..............s..lp........sGplsstsGphslcsl.pcAschsh.....sG.....ch.....sAllTuPl..pKt.s..l.pp.A...........G....h...s......FsGHTEal...uc.....hst...........................s.p........c.sl.M.ML..u..s.c.................................pLRVuLsTTH.lPL+clscslT.ptlppslpl....hppsL......+p..........cF....G.l..spP....R.IhVsGLNPHAGEsGhhG.p.EEh...-.h.Ih..........................................................Pulc..p..h..+......tp..G..hp.lh......G..........PlPADTlFp.t.........................hh.s.ph.........DuVlAMYHDQGL.sLKhhuF.....s...........c.........uVNlTLGL..PhIRTSVDHGTAhD.......lA....G.....pG..pAcssShhsAlphA............................	0	212	441	582
+672	PF00934	PE		PE family	Bateman A	anon	Pfam-B_253 (release 3.0)	Family	This family named after a PE motif near to the amino terminus of the domain.  The PE family of proteins all contain an amino-terminal region of about 110 amino acids.  The carboxyl terminus of this family are variable and fall into several classes.  The largest class of PE proteins is the highly repetitive PGRS class which have a high glycine content. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis [1].	20.60	20.60	20.60	21.10	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.30	0.72	-3.90	135	4012	2012-10-01 21:44:22	2003-04-07 12:59:11	15	13	103	2	365	2559	0	90.80	46	26.20	CHANGED	MSaV.hssPEhluAAAsDLuuIGSsluAANAAAAuP.TTuVlAAuADEVSAAlAALFuuHuptYQslSAQAAA.FHppFVpsLsuuAuuYAuAE.AAN	..................MSaV.hssPEhluAAAs-LusIG.Ss.luAAN.A.AAAus....TT.ull.A.A.uADE.VSuAlA.A.LFuuHuptYQulSAQAAA.FHppFVpsLssuuuuYAsAEAu......................	1	142	177	350
+673	PF01095	Pectinesterase		Pectinesterase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.20	21.20	21.30	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.76	0.70	-5.85	35	2674	2012-10-02 14:50:22	2003-04-07 12:59:11	14	76	936	20	1177	2391	56	228.80	26	55.97	CHANGED	slVVApDGSGpa+TIsEAlsssP.c+uspR...aVIYlKtGlY.cE.NVcVsKcKtNlhhlGDGhsKTlITG.phshhcGs.TTFcoAThAlsGcGFlA+DIsFpNTAGPpKHQAVALRVsuDhulFY+Csh-GYQDTLYsHSpRQFYR-CsIsGTVDFIFGNuAsVFQsCpIhs....R+PhssQ.pNhlTAQGRpDPNQsTGlsIQsCpIsuss-Lh....ss.sshtTYLGRPWKpYSRTVlMpShIsshIsPtGWhtWsG..sFALcTLaYuEYpNsGPGussupRVKWsGa+slhosp-AppFTlupFI.tGs	...........................................................................t..t...a.plttAl.t..h....................................................................hl....l..G...Y...................E.......l.......l..................l...h.......G...................s.................................s..........................h.....................................t...........................................................................t.....................s.....s...............h..............p.............o....A.......o..........h.......h.........s........t........u......s.....s.hh...h....p..s........lsh........p............N.............o..............h...............G............s..........t.......t............p..............p....A....V.........A..l..p..s..s..u..D..........p.s........hh.....ps..ph........h.Gh.QD.Tl........a...........s............p...........s............s............R.....p...........ha.p...........s..shIpGslDFlaG..p.u.s....s....l.F....p.ss.plhs.........h....t.....s.............t......t...........t.....s......h....l....s..A...u.p................s...t...............h..........Gh........hh.pspltus.....t........................................h.LGR..s....W..........t................h......u................p..............s..........h.......h..s.hs..........t...l......G........a......h................................................................h...............ph.s........G.s.................................................................t.....................................................................................................................................................................	0	261	757	995
+674	PF04710	Pellino		Pellino	Mifsud W	anon	Pfam-B_5882 (release 7.5)	Family	Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase [1,2,3].	20.00	20.00	20.40	34.90	19.30	19.90	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.47	0.70	-5.83	8	257	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	97	3	152	252	0	347.90	58	92.85	CHANGED	up-ptsu.scpsl....+YGELIVLGYNGsLPsGDRGRR+.S+FsLpRRs+ANGVKPSshHhl.poPpsSKAlssKsQHSISYTLSRspoVVVEYsHDscTDMFQIGRSTEsPIDFVVhDT...........lPGu....t-sp-stspQSTISRFACRIlC-RsPPYTARIYAAGFDoSpNIFLGEKAsKW...psscGcMDGLTTNGVLlMHP+sGFo.E-SpPG...lWRElSVCGsVYoLREoRSAQp+GphV.p-sNlLQDGoLIDLCGATLLWRousGLp+sPT.+cLEtllpclNAuRPQCPVGLsTLAFPphp+.......tss.s-+QPWVYLpCGHVHGaH-WGpccEpt.p.cRcCPhCRsVGsY...VPLWhGsEPAFYlDsGsPoHsFsPCGHVCSEKTstYWuphPLPHGTpAFpAACPFCAs.LsGppGal+LIFQs.PLD	...............................................................at.LllLG....YN..Gs......Lss.G...D.+....G.RR.........+.S+hsLh+RscANGVKssshHhh.soP.......suKA...lp.s.+...sQHSIS..YTL............SRspoVlVEYscDssTDMF..QIGRSTEs.IDFVVoDT.............................hsGu.........s.ss-s.tssQSTISRFACRIlC-Rps.P.aTARIaAAGFDSS+NIFLG..............EK..AsKW.....................+ss.D.Gp.MDGLTTNGVLVMH.Pp...sGFs...p-S.....tPG......................lWREISVCGsV.aoL..R..E......oRS...A..QQRGKhV............EsEoNhL.....QDGoLIDLCGATLLWRTu...........p..G.........L.+...........sPTh...+pLEuhRpElNAuRPQCPVGhsTL.....uF..Pohtp...............................pps.sc.cpQPWVYlpCGHVHGaHsW.........Gp.cp....-........p...t................s...........p.......p..........RcCPhCRtlGPY.VPLa.LGpEs.....uh.....a...lDsGP.PoHAFs.PCGHVCSE.KTstY.WuplPLP.HG...T...c.sF+AACPFCut.Ls.....G-pshl+LIFQs.slD.....................................	0	35	49	95
+675	PF02452	PemK		PemK-like protein	Mian N, Bateman A	anon	Pfam-B_2134 (release 5.4)	Family	PemK is a growth inhibitor in E. coli known to bind to the promoter  region of the Pem operon, auto-regulating synthesis. This Pfam family consists of the PemK protein in addition to ChpA, ChpB and other PemK-like proteins. 	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.78	0.72	-3.85	306	4707	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	2273	13	846	2702	289	106.10	23	83.07	CHANGED	c+G-lhhlsh.....ts..sh.GsE.......tt.hRPs........lllsss..hhs.ph..t......slllsPlT.o....pht.t...............shcltlp.s...pt..pt....................ohlhs-plpolc.+p...Rl....t.c........plGp...............ls..spphppl.ppslthhl	......................................................+G-lh.h.ssh......tP.......s...GsE.................st..t......RPs........lVlsss...hhN.ph...s..........slllsslT.o...........php.t.t......................................................................shcl.ls..sp.....th..t.......................uhlhh-plpols...+p.Rl..........t.c......................plsp.......................ls....p.p.h.h.p.p.l.pptlth..h..............................................................................................	0	269	586	752
+676	PF01804	Penicil_amidase		Penicillin amidase	Bashton M, Bateman A	anon	Pfam-B_1410 (release 4.2)	Family	Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins [1]. Also in the family is cephalosporin acylase Swiss:P07662 and  Swiss:P29958 aculeacin A acylase which are involved in the synthesis of related peptide antibiotics.	21.30	21.30	21.80	21.70	17.40	20.80	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.03	0.70	-5.50	21	1530	2012-10-03 21:14:07	2003-04-07 12:59:11	13	8	899	125	501	1655	2079	651.20	21	92.28	CHANGED	tsVcIh+Du.aGlPHIhAssptslhauhGYspApDRLhpl-hh+tpApGphuchhGs...........stlssDhhh+phthsp......ssctphpshssp........tshlcuYusGlNtYlp....t.tp.hPh-ashhshp........Pc.asshDshtlt.hhhhphsus.............h......t.hhshasshh.t..................................h.tshs.hts................h.thstthsspsts.............hGSNsWsluup+TssGpslLhssPHhsatsP.shahphpLps.suaclhGsohsGhPhl.hhGaNsplAWuhTsstschhDhYt.pls.p.ssspYhas.Gpapshcp+ppsltV+s..sp.....shphplhcThcGPVlspsss.............sshshthsshtpsspsh.sahphscAcslpphpp.s.tpthtssshNhhaADtpGsIuahssuhhPh....pss.ps........hhPssG........uph-WpGhhs.hpt...hPphhsPs.......pGalhsuNppsh.........ssshsht.hssthhts.....hRspphhphlstpss.........hshcshhplphs.stshhschhh.................llcshp.........ssssssppAhstLtuWstphsssopuAs.........lathahcthsppshhsthst.hhsshhs.h.......................s.h.hssssshh.tttp.........sthlspuhspuhs..................hpsphG.................shshpWGchpp.........hh.hpshshpu.........sssshs.hhGshsshsssths.sstsssshtsshs.....hphss.hspsttlhssupSusPtSPHYsDQh.haspspahslhhs.pplptphpt	.........................................................................................t..splhcDt.hGlPHI...hA.p...s...tt.c...hha...u...GYspApDRhaph-hhR+hut...Gpluchh..G.................ttlt....Dt.hhRt.h.thtp......ssptt..h.s.t.h.ssps...........pphl..p...uYssGlNsalt............t...t...hhPh.-a.thhsht........s.t.W.ps.Dsl.hh..h.....hhh.hh..ph...tss.......p.................h..............h.................t.....h.....s...h...h.s.t..........................................................................................................................t...........................................t.hh........h..........................................................hGSNsWslusp+o.tsGps.llss.sPHh.sh.t.h.P....shaa..........t.hp....L........p.......h....s..........t................h.......s......lhGsshsGh.Psl.hhGaNt...........c.lAWuhTs.sh.s.D..Dlah.phs...............t....p......s.......t..t.....Yh......h.s...s......t........h..hp.tp.pp.sl..tV+s...st...............shp.hslh....T..t.a..G.Pl.lpts.t.................................................thshuht.h.sh..t...s...s..t.s.h....shhthsp..A..psh..pphhp..s.h........pt......h.t..h..s.s.Nhlh...AD.......p...G..s..I..uahssG.thPhR.....tthps.....................................................hhPssG.........psp.hp..W.p........G.h.hs..hpt.........hPp.......hs.Pt..................pGalhsuNsp.h...........................s.shsh......hs.....thh.s..........Rs...pcl....t....p...h....l...t...t...t.tt...............hs.hpsh..t.hphD..p...hs.......h.u...p...hh......................................................h.hp..hhp..............sts..hp.ph....hp....hL..t.t..W...st.ph....sh.....sshush...........................................lhthah.pt.....h.h...p...t...h..h.t...s.t.h.s...........h...ht.....h..s.........................................................h.........s.....s......h...h.t..t.......................hsthh.tts.h.ttsht..................httt.h.G.............................pht.W..Gphpp...............hh.hts.h.s..h..s....................................h.hs...s..G......s..t.t.s.h..t...s..........s..t...h...t.......................t......t....h............h...h..usu...ht...........hlhs...h..sc....s....tuh.h.h..hs.hGp.S.G.ps.hS.....saatDthp.ha.h..p.s.p.hhsh.hp.tth.....t..........................................................................................................................................................	0	178	337	452
+677	PF01469	Pentapeptide_2		Pentapeptide repeats (8 copies)	Bateman A	anon	Bateman A	Repeat	These repeats are found in many mycobacterial proteins.  These repeats are most common in the Pfam:PF00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to Pfam:PF00805 [1], however it is not clear if these two families are structurally related.	20.30	20.30	20.50	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-9.90	0.72	-4.32	126	12308	2009-01-15 18:05:59	2003-04-07 12:59:11	13	89	95	0	878	9127	90	40.00	46	47.97	CHANGED	uNsGshNsGsuNhG.hNhGsuNhGshNhGsuNsGstNsGs	......................NhGhhN.sGs.sNhGh...hN.s...GssNsGhhNsGssN.sGhh.NsG...............	0	480	495	874
+678	PF00391	PEP-utilizers		PEP-utilising enzyme, mobile domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.	23.00	23.00	23.10	23.20	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.57	0.72	-4.41	179	11592	2009-01-15 18:05:59	2003-04-07 12:59:11	18	59	4567	47	2573	8381	2287	81.70	31	11.56	CHANGED	pspp..t.hh.ps...ILVscc.lsPuphs..hshppltGlloppG.Ghs...SHsAIlARshGIP.sllGs.t.s.............shpt......lps..Gphlhl...DGppG	.............................ts.....t.hsps..sILVsc.c.hsPsphs......s.h.p...ps..tGllTsp..G.GtT...SHuAIlARshGIPsVlGs..s..s.....................sspt..........l.ps......Gc..hlhl...DutpG...................................	0	893	1669	2174
+679	PF05131	Pep3_Vps18		Pep3/Vps18/deep orange family	Bateman A	anon	Pfam-B_6057 (release 7.7)	Family	This region is found in a number of protein identified as involved in golgi function and vacuolar sorting. The molecular function of this region is unknown.  The members of this family contain a C-terminal ring finger domain.	20.50	20.50	20.80	20.50	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.82	0.71	-4.77	31	318	2009-09-11 06:43:15	2003-04-07 12:59:11	9	7	276	0	229	324	2	145.80	26	15.40	CHANGED	GlhaGplshsssss.........pplhppspl...........h.psplssspss............hulsLTpaHlLlLhts+lhAlNpL.stplVa-psl.........hpstpphlGlssDs..tpsThWlaospslFElslpcEsRclW+lalcppcF-tALpas+s.....ssp+DtVhstpu-ahhpc	...........................................................GlhhGpl..t..ts...........hhsptph...........h...st.hststss.................................huhsLTpaHhllLh..s..s..+..lhslspL..st...p..lVhcpth.........hpthtphhG...lspDs...............tp..s..shWlaTsp.slFclhlpcEs...................RslW+laLch............pc............F-tAhpas+s..........stphDtVhttpu-hhhp.p.................................	0	82	129	192
+680	PF03051	Peptidase_C1_2	Pept_C1-like; 	Peptidase C1-like family	Mifsud W	anon	Pfam-B_2136 (release 6.4)	Family	This family is closely related to the Peptidase_C1 family  Pfam:PF00112, containing several prokaryotic and eukaryotic aminopeptidases and bleomycin hydrolases.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.53	0.70	-5.96	13	1894	2012-10-10 12:56:15	2003-04-07 12:59:11	10	5	1149	26	416	2017	382	362.80	34	93.53	CHANGED	pLos-plppFspcasucPphtlspsAsp+sGlh-Ashsc.psptchspVFSh-lsT-..sVTNQKpSGRCWlFuALNshRHshhKcaclc-FEhSQuYsFFWDKlE+uNaFh-pllsTA..DcslDuRhVpaLLssPppDGGQWDMhluLlEKYGlVPKpsaPEo.asossSptLNshLsc+LRccAltLR.pLhppGss.cplput+-chLsEIa+lluhsLG.PP....csFsaEYRDKDKNYHp.+slTPh-Fac+YVs..hDLcsaVsLlNAPpsD+PYsKlYoV-aLGNVsGGpplhalNlsh-hLKchslsQlKsGEuVWFGsDVu+ph-RKsGlhDsclYph-plFslchph..oKA-RLcaGEShMTHAMVlTGVDl.ss..Gpsp+WKVENSWG-csGpKGYFVMSDcWFcEYsYplVVcKKaLPc-llcsh-p...pPIsLsPWDPMG	.....................................................................................................................................................................................s.lp.p.htph.tph....ts.t.thhtpuh..p.s.sl.ts...p...ps..h.........p.....s....s.Fo..h..c.ls..pt.....tls..sQc.tS.GRCWhFuuLNshRh.thhpph.p..l.....c.....p..F.EhSQ...sahhFaDKhE+uNhFh...ppl.......lt..ou..........sp.hssR...hV...palhps.P......pDGG.Q.Ws.M.hsslhc.KYGlVPpps..h...P..Eo...h....s.o....p..so....pt.hs...thLs.ph....LRp.....u..h.LR...phh.t........p.............s..................t............s..........................t.................t.........l..........p..tt+pphL...ppla.phlshsLG....PP....cpFsa.t............a.......p......D.c...-.......p............p....a..p...............t.t......shTP.pFacc.als..........hs..........l.p.-....Y....V.s.lhN.s.....P...c.+sas+.asl-h.sNlhs..u....p....hpa.lNlsh-th+ch.shsp.l.p..sGc.s.V..........WFGsDV.u.p.....s.p.c....t...G........l..............h.........................s...h......sh....a......ch........p.......t.....h........h........s........h.....p..........h.p...............sK..u..............p..........R......................L..........p...........ht..................-.......S............hh.o...HAMslsG.....Vc.......l.....ts.......G..............p.......s..p.+..W+V.E.....NS..W.....G.....c......c...s...G...p..........c.......G.aa.sh....o..-sW..hccas...aplVVcKchlst.....-...hth....hpt....ps.h...L.sWDPh.................................................................	1	131	242	329
+681	PF00112	Peptidase_C1	Cys-protease; 	Papain family cysteine protease	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.92	0.70	-4.47	157	7017	2012-10-10 12:56:15	2003-04-07 12:59:11	18	153	1160	373	3137	7739	473	199.90	29	53.16	CHANGED	lPpshDWRp..ptss..VoslKsQG...pCGSCWAFSssuulEuthtlts.....tphlsLSEQpLlDCst....sp..........GCsG.GhhppAapalhp....sGls.oEssY.......PYp.....upc........................spCchp.ppp.h.....sphssass..lsts.......sEpsltptlsp..GPl.uVulsusp....sFphYpuG..........lapt...pCss......tlsHuVhlVGYGsps.....................................GpsYWll+NSWG.ssWGE.pGYh+htR...shs.....spCG..Isspsshsh	..................................................................................................................................................................PtthDhRp..............h....l.s......l....+..s.Q..G..........p.C..........G....S...........C......W....A.....F........u......s.s.......u.........s...lE.......u...tht...h......t......s..........................t......p.......h.......h..............s..........L......S...t.....Q....p......l.....l.....s....Cst.......tst.............................G.C...s...G....G..h..........t...t.......A.a.....p...alhp............t.G..l...s...s.-...p..sY.............................P.Yp..........utp...........................................................................spCphp....tpt..................hphp.s.a..hp....ls..s.......................pptltp.t...l.h..p........G.......P...............l...............s...su...............l........p....s....t......p...............a..................h.......Y......p...s...G...........................lapt................ssp................th..sHuVhlV.G...a..G.s.p.t..............................................................................................sh...Y..Wll+..........N.......SW............G.......p.p.........W.....G.-...pG..Y.hph..tt...s.t.........Cs.lt.......h............................................................................................................................................	0	1477	2033	2663
+682	PF01650	Peptidase_C13		Peptidase C13 family	Bateman A, Caffrey C	anon	Pfam-B_1302 (release 4.1)	Family	Members of this family are asparaginyl peptidases [1]. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation [2]. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified.  This has formerly been characterised as a 'haemoglobinase', but this term is probably incorrect [2].  Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue.  Both forms have been recombinantly expressed [3].	20.40	20.40	20.40	20.50	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.83	0.70	-5.09	34	952	2012-10-03 02:24:44	2003-04-07 12:59:11	13	35	545	0	478	982	50	226.40	30	53.62	CHANGED	pWAVLVAGSsGa.NYRHQADlCHAYQlLc+.tGlcsEpIlVhMYDD.IAps.pNPhsGhlhNpPp.....u.....pDVYpG.VshDYsGpsVsscNFhuVLhGscstltt.usGKVlpSsssDplFlYaoDHGuPG...lluhP....ts.LaAp-LhcsLpphHspspYpchVhYlEACESGShFps..LPpslslYAsTAuNucESSausYC.............sssphsTCLGDhaSVsWhEDo-t.pslpt..cTLppQachVKpcT.......ptSHVhpaGDhslsp.hlsp.a....................................................hGs	.......................................................................................pWuVllu.s.S.p...hahN.Y.RH..AsshphYphl+c.hGl.-ppIllhhhD..D.hAss..............cNPhsu.lh..sp...p.............t....slY..t.s..l...........hDYpu..cVssc................sFht..lLh...G.ph............spt+....hl....o..s.s.ps.p...l....h.............lYho.sHGuss...............hLth........sspplts.......t-Ls....cs.l.p...phat....cp+.................Ypph....lh..hl-sCpuuoh.............hpt...............t.s.......s......lh......s...hsuo.p.ssEs..Sa.up...h...............s..phtshlsD...h...a...o..h.......hhc...-p..............p.p....sltp.ap....h.....................................................t........................................................................................	0	181	292	392
+683	PF00863	Peptidase_C4		Peptidase family C4	Bateman A	anon	Pfam-B_232 (release 3.0)	Family	This peptidase is present in the nuclear inclusion protein of potyviruses.	20.80	20.80	20.90	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.49	0.70	-5.40	39	1088	2012-10-02 13:45:52	2003-04-07 12:59:11	14	30	161	9	0	1336	7	226.80	49	9.57	CHANGED	aEupShhpGlRDYNsIus.......slCpLpNpSsutppslaGIGaGshIIoNtHL...F++NNGp....LplpopHGpF..plcNosplplp.lpG+DlllI+hPKDaPPFsp+l+FRsPpps-+lChVussFQppphsspVSEoShhhs...ssusFW+HWIoTp-GpCGhPlVuspDGtIlGlHS.....LsstssspN...aFsshscsF.pphLpshcphpWsptWpaNsspluWuulplhsspPpt.FphsKhls	............................................HESpShaRGLRDYNPIusslC+LsN.sS-utssshaGlGa..G..sh..IlTNpHL...FcRNN.Gp....Lpl+...SpHG-.F...slKNTspL+l.h.P.It.....s...RDlllIRhPK......D....hP...P.F......Pp+.LtFRp.PccsERlC.hVG..o.....N...F.....QpKSl.o....S..hVSETSshhP............lts..SpF..WKHW...IoT....cD....GpCGhPhV...STp...DG..p...IlGlHS.....LAN.p.sopN...aFuAFs--Ft.pcYLpsh-sp......cWl......KpWpYNsstlsWGoLplpsup.Pp..u...FKloKLlp...................................	0	0	0	0
+684	PF02902	Peptidase_C48	Ulp1_C; 	Ulp1 protease family, C-terminal catalytic domain	Griffiths-Jones SR	anon	Structural domain	Domain	This domain contains the catalytic triad Cys-His-Asn.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.61	0.70	-4.72	27	3178	2012-10-10 12:56:15	2003-04-07 12:59:11	14	120	647	37	1892	3126	158	164.70	15	27.92	CHANGED	palsstlhthhhchh........pstpppcsthhsohFhshLp.....h................pphhsuspp.hpt......hhchDhlahPlp.h........stHWshl....hlsltcp.......................................pIhhhDSlhshpp..........htshsthh.aLhpp..hhptp..t..............p.ht.hhth.plPQp.sstDCGsashpal-hhspshs.p.........l...ppchtth+pchuh..hchhtstl	.....................................................................................................................................................................................................................................................................................................................................t...t.p.h..l.h.lPl.p..................ttHWhLh.....llsh.ttp.............................................................................................................................................................................................................pl.h..hhD..S.h..t.ttpp.........................thh.p.th.h....p..h.l.....tt.....h.....t.....................................................tth.t....h....h....h...............t....h..s..p..Q..t..s...s.......c..CGh.alh....t.hh.ch....h....hp...t.........................................................t.h.....................................................................................................	1	468	899	1346
+685	PF03416	Peptidase_C54		Peptidase family C54	Bateman A	anon	MEROPS	Family	\N	25.00	25.00	25.50	25.40	20.40	23.30	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.91	0.70	-5.27	14	700	2012-10-10 12:56:15	2003-04-07 12:59:11	14	10	298	10	424	693	4	260.10	32	62.57	CHANGED	pshhpsFhpDhtSRlWhTYRcsFssI.............................ssoshToDsGWGCMlRouQMLLApALlhp+LGRsWphstp.....................................................pppttapcIlphFsDp...susaSIHphlph..............................Gtpt.sKp......sG-WaGPsssupsl+pLscts.....shssl.plaVuhDsslhh--.hppss.....................................................................................................tstapPlLlllPlRLGlsclNshYlctLppshphspSlGIlGG+Ps.puhYFlGaQsDcllYLDPHhsQpslshspcshs......................................................poaHs.phhp+lphpphDPShslGFhC+scc-F-shppplp	..................................................................................................................t...tthhpDh.S+.l.Wh.TYRptFs.sl....................................................................................................................................s..s..s...s..hToDsGWGCMlRsG...QMlLAp........uLlhth.....LGR..s.Wp.h...tt....................................................................................................................................................t.t..thhpll.p.....hF..hDp.............p.....usaSlHph....sph................................................G.ht....GKp.......sGpWa...GP.ss....suphlcphs..t.........................th.ssl...tl..a...l.s...Ds.sl.h.h...p-hhphht...............................................................................................................................................................................................................tth..pslllLlPlRLG.h.p.p...l.N....h.Yhpslc.....thhp.h........tslGlhGG+P.p..puhYF.lGht........s..s..p.l.lYLDPH.h.s.Qsh.l...s....h.p.t..t.s..h.......................................................................................................................................................poaHs...pp...p+hthtphDPS.....hsl........GFh..sp..s.pp-apphppth.t..............................................................................	0	158	222	329
+686	PF01433	Peptidase_M1		Peptidase family M1	Bateman A	anon	Swiss-Prot	Family	Members of this family are aminopeptidases.  The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues.  This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activity [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.50	0.70	-5.38	33	7280	2012-10-03 04:41:15	2003-04-07 12:59:11	15	83	3187	81	3135	6965	1743	332.40	23	43.69	CHANGED	RLPssltPh+Yclplp...sphpsh.......sFpGpssIplps....pp.sssplslcspc.lsIp.slplps..psss............hphptppph....lplphspshtttp........hpLplpasu.lss....s..htGhYtohYhp....sGpp+hhssTQhp.sstARpuFPCaDEPshKATFsloltpssph..sulSNhs.hpsp.hp.ss..hthspFppT.shMSoYLlAahlu-hphl..pspsps..tl..lclaucsuttppup..aAL-hst+hlpahEcaashsYslP.....KhDhlAlP.-Fuu..GAMENWGLlTYREssLLh-.t..ostppcppluplluHELAHQWFGNLVThcWWssLWLNEGFAs.ahEahssctlts..phphhphalhsph..ppshttDuls....ss+Plp....plssPsplsshFs.slsYsKG	................................................................................................................................................................................................................................................................................h.................................................h...u.........h.h..................................t........h......l....p.........t......hp..l........t....h.....h.................................................................................................................hh.l.............t.........h..............................h.l...l..t..ht..s.........tt.......................t........htG...h..a............h.........................t...p...t..........h..h..........h...TQ.....h.E.....s..p...........ss.R...p.......hhs....s....h....D....c..P.........s.h..+.........A..s.........a.s.h.p...l....ts..s...........psh..............hsl.....SN..t...s.....h......h.......p..........p...........t...............t.........h....t.....s.....................hthh....pa......p.p....s.......h....s.o..Y...L..hA....h...s.s.G....c....hphh.................php..sps....................t.h...lp.......l....a....s...p............s....t.........h....p..p.st...........as....h..p.......h...t..p..s.h.p.a...h.c....c......h...a...s...h.....Y......s....hs....................p.h..p.hl..sl.s.....p..F.....sh.......G...AME..N..h..G...L.......h.a..p...p..p...h....l....L....h......s......t........t....s..............s...................t.....t........h........t..............pl..tt.....l...........l.u..H...........E.h.u.Hp............W.h.............G..N..h..V..T.h.c...........W..p..p.L...W.L.pEGass.ah.p.h....h.......h..s.s...p.h......ts.........................h.ph....................p.....h...h.h..p.th.................t.h.t........Ds..s...........s.cslp.................t..p........p.h..p............ph...as..hhsYtKG.........................................................................................	0	1008	1673	2600
+687	PF01431	Peptidase_M13		Peptidase family M13	Bateman A, Dudgeon T	anon	Swiss-Prot	Family	Mammalian enzymes are typically type-II membrane anchored enzymes which are known, or believed to activate or inactivate oligopeptide (pro)-hormones such as opioid peptides. The family also contains a bacterial member believed to be involved with milk protein cleavage.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.42	0.70	-5.15	21	3320	2012-10-03 04:41:15	2003-04-07 12:59:11	16	34	1562	10	1433	3043	301	191.10	36	29.63	CHANGED	NAaYssshNplshstslh.sPaassphs..pshNaushGsVluHElsHsFsspGspas..h............tah.tpspssapstspCslcpasthsssstst.....shsGspThtEslADluGlphAhpshpp......psss-ppl.s..hpt.s..phhahshAtsaCp.pppspstlh....psHuPsphRlNsslpshPtFsssFsCp.Gs+MascPcpps	...............................................................................................NAaYsPtpNp..I.sFP......A...........u.I.LQs.P.F.a.....s...h.p.ts..........puh.NY.GuIG.s.VIG.HEl.oH.uFDs........p.G....t..p...a...D...tpG.s.Lp............................sWW...op.p...s.hp..tF.p..p...+sps...hlc.Qa.s.....s.h.......ps.........h...............s............s..................................................p.........l...........N...G....p..hT...lu..EN..IA......Dh.GG.lphA....hc..Aap........................th.p..p...t...p...h..ss.........h.p........h....s..tQ.........h.FF..........l................sa..A................p............l.Wp................t........p....h......p.......s.....c.t..........h......t.............h....l.t..s...D........s.......H.u.Ps.......c.h..R....sss.s..lpNhsp.Fh..csF.sspt.u.ss.Mh.s.cpcl..................................................................................................................	0	539	753	1171
+688	PF05193	Peptidase_M16_C		Peptidase M16 inactive domain	Yeats C	anon	Yeats C	Domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.01	0.71	-4.61	181	16090	2012-10-02 15:41:56	2003-04-07 12:59:11	16	64	4451	253	5211	13286	2764	179.20	14	37.15	CHANGED	slstpplppahpphYpss.phslhlsGslshp..plhphhp....chhuplst.........................................................................tsp.hthsht..thttt.hhh.tt.........s...pspltlua.sssh...........................................sp.cthshpllspllust.........................htutLhpplp...............cpsh...shsstuh.hptht......ttuh.hslhhssssp......phpc............hhphhhptlppltpp.t...hsppc....lpcs+pth	.......................................................................................................................................................................................................................................................................................................................................hshppl.hp.a.a.p.p..a.Y..p.ss..p.h..s..........lhl...s...G...s........h..s..........p....p...h.h...p.h...hp.......ch....h.u..p.httt...........................................................................................................................p..ht.h....s..h...p.............t.......t..t....t..t.h.h.h.tpt..........................s....p..p.spl....t..l..u.....a..p.....ss..sh..........................................................................................................................s.p...c.t....h..s...h...p......l...h....s....p.l.Lust.................................tu.t.L..hp.p.lp..........................cp.sl.......sh..s....s..t..u..t...hs.sht..................t.uh...h.....t.....l..t..s.s..s..s.sp...........phpp............................hhp.h.lhp.t.............l...p.pl.....t..pp..s........hspp-...lpphpt..h............................................................................................................................................................................	0	1802	3187	4395
+689	PF02789	Peptidase_M17_N		Cytosol aminopeptidase family, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_990 (release 3.0)	Domain	\N	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.42	0.71	-4.38	103	3629	2012-10-02 00:07:53	2003-04-07 12:59:11	12	10	3099	51	1002	2638	1020	122.30	21	24.73	CHANGED	lls..lh..........cssthssss..........lc.pthsu.hlpphhpptshsGKhGpshh..lhshs.sh....hppllllGLGcppp.........hstcsh+pssusssctlps.hpsppsslhls...................ttspshspGhhLusYca.sca+opp	...................................................................hs..s..........tthc..th.su..hlpt.l.lcp...s...p.....h.p.G.K..Gpshh.....lhtss...s..................sp+llllGhG....cppp...............................h.s.t.c.ph+ps...hu..pshpsL...ps...t...........ts.tps.shhls.........ttts.................ttsptssc..usthutYpF.cpaKop............................................	0	310	592	816
+690	PF02127	Peptidase_M18		Aminopeptidase I zinc metalloprotease (M18)	Mian N, Bateman A	anon	IPR001948	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.40	0.70	-5.98	9	1876	2012-10-02 19:46:12	2003-04-07 12:59:11	10	13	1229	44	661	1854	254	401.10	32	91.82	CHANGED	FlspusTPaHsVppltc+Lh.ptGFppLpEppsWt..l.pPts+YFls+NtosllAFulGsphcstsGhslluuHTDSPsL+lKPpuppp.sptah.lulpsYGG.Ih.poWhDRDLuluGhVhlKss..tpph.phllclccPlhpIPsLAIHLs+sh.pshphspcschhslhuh.s......p..h.sptc..........pth+hslLpllscchG...lps-D...llsh-LhlhDspsuplsGhcccFlhusRLDNphssasuhpuLhpstps......csphplsshaDpEElGSsoupGAcSsaLptVLcRlshthppss.....hhpptl....sKShhlSADhsHAhHPNYsspH-psatPhhstGsVlKlssNtR..YuTsusstshlcplAptss...V.lQhhhl+sssPsGoTIGPhhuucpGlcTlDlGss.LuMHShREhsustDlh.shphapuFF	.....................................................FlstusosaH...........sltphtphLp..ps..GFp.pLpE.........p..c.p.Wt..........h..ps.....u..s+.aahs+ssusllAat...lsp...p......................t......p...G..................hpll.GuHsDSPsl+lKss....s..php.......ppG...ah..........l....sschYGG.lh.tsWhDRsLuluG+lhh+.................ss.......................t...............h..........st.ll.c.h.scPlhtIPsL.AIHLs+..p.h.p.p..s...h..ph.s..ppp...ch...Plhuhhs................................t..............................................hc.tl.hpl.l.sc..phu..........lp.tc-......llsh-L.lhssp.uphhGhs....p-....hltusRlDshsssasulp.Alls....stt........................................................................t...................p.......st..lh.s.haD+EElGS.totpGA....pSshlps....slpRls....t..s....h..s.tsp............t.h.pthh.........................spShhl.SuDsuHul.H....PNY...s.c...p.a-............s...p.ps.hlstGsVlKhss..spR......Yuosuss...s...s...h...h...p...p...l...s...p...p.ss........................lshQ.pahhpss...sGoT.lG.s.hh.s.u.p.h.Ghp....slDlGss.LuMH.ShRE..hsuttDlhhhhchhpuFh...........................................................	1	270	456	592
+691	PF01546	Peptidase_M20	CO_pept_M20; 	Peptidase family M20/M25/M40	Bateman A	anon	Pfam-B_253 (release 4.0)	Family	This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [1]. Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null --hand HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.37	0.71	-4.79	366	29469	2012-10-02 19:46:12	2003-04-07 12:59:11	23	76	4930	91	7433	26828	10363	326.10	13	78.41	CHANGED	hltuHhDslP.......th......p.s...................................GhhaupGpsDtpuhlhuhhpslpph........ttphps.slpllhpssEEsu.....u........................Gsphhhcs....................................hth+....shsh..sc.s.hts...............shpushshhhhhhsspuptussshssssshhhsshhhhhhpthhspttsshpssshshs.......................................................................................................................thsssssssshsttshhtsthpshppthpthhpthhtthtpthstthttttthphhtshssshsss.h....hphlpps..spp.h...................t.ph.sssuu...pDhshhtt........s.sh.hlshusts...........thhHs.ssEpls..sslhtusphhtphltp	.......................................................................................................................................................................................................................................htuHhDs.lP..........t...tth.........................t.................................................................................ps...s....h..h.....a....u....p....G....t....s....D.t...p.us....l.h...u.h...h....t....s.......l..pt.h..................t.t.p.h.p...s....s..lp.l..l..hp..s....s..E.Esu...t.........................................................................Gsp..t.h...hpp.........................................................................hthc.........shsh.........sc...s...t.th.......sttsssttththttttsttsstttsstshhtsshhhhthhthhtttttt.tttthhhhh.....................................................................................................................................................................................................................................................................................................................tsssstssh.thtthttthtthttphtthhttthtthttthstthththphphh.sh.hs.sst......h...hp.h.h..t..ps....hpp.hhh....................................ts.p.h.t.s.h.t..u.u...........pD..s..s...h.ht..................................t.s.h.s...h.l..h.h.usss.................tthHs....s...s...E...t.l....s....hps.l..tssphhhphh..t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2236	4510	6175
+692	PF00814	Peptidase_M22	Glycoprotease; 	Glycoprotease family	Bateman A	anon	Pfam-B_1670 (release 2.1) & Pfam-B_4550 (Release 7.5)	Family	The Peptidase M22 proteins are part of the HSP70-actin superfamily ([1]). The region represented here is an insert into the fold and is not found in the rest of the family (beyond the Peptidase M22 family). Included in this family are the Rhizobial NodU proteins and the HypF regulator. This region also contains the histidine dyad believed to coordinate the metal ion and hence provide catalytic activity. Interestingly the histidines are not well conserved, and there is a lack of experimental  evidence to support peptidase activity as a general  property of this family. There also appear to be instances of this domain outside of the HSP70-actin superfamily (e.g. Swiss:Q9ZM49).	24.80	24.80	24.80	24.80	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.90	0.70	-4.90	113	9668	2012-10-02 23:34:14	2003-04-07 12:59:11	20	26	4927	28	2530	7185	5233	230.60	26	77.47	CHANGED	plluphhhspht.h.....G.GlhPp.suRpHtcplhshlcpsLpcu...slshp..-lDsIAsopGPGhhsuLhVGsshA+uLAhuhshP.lluVsHlpuHhhsshht..tt........P.........lsLllSGG+oplhhspt..tpYchhGpol........DsAsG-shD+su+hlshsh.......s..uu...tlcphu..tu.......hp..hs.s.h............hshSFS....Glcosshpth............................slshuhpcsshshLspts.cshth..........hssppl..llsGG..VuuNptL+p.......tht.hstp.....t.h.hhhPs.t.assDNuAMIuh	...................................................................................................t..ss...RpHs.cplh.shlpps...Lp.pu......................sl..s...hp.......-l...DulAho..tGP.....G.........h.....s.uL.h.l...G.lssA...+u.LA..........h.u....h....s....lP..lluVsplt....uhh.h...ss.hhp.....ps....................t.P........lslll....s....u....t....+......s....p........lh...h...s.........................p.....a.....p....h.....h....u..p.s..h...........css..h.u.-..s....h..s..phuchh.th..............................................tt........t............................................................................................thsas....G..h.s.h...h...................................................................................................h...t....h.............................................................................h...h..........................................................................................................................................................................................................................................	0	882	1633	2143
+693	PF04389	Peptidase_M28		Peptidase family M28	Bateman A	anon	Bateman A	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.54	0.71	-4.54	65	5682	2012-10-02 19:46:12	2003-04-07 12:59:11	12	79	2007	144	2682	7975	2221	184.50	20	35.77	CHANGED	phllluAHaDo.hs.................htsGAsDsuoGs...AslLElA+hls...p..t.p....pp..................slhFlhhsuEE..............pGLhG..Sctast......tph................................hppltshlNhDh...h...Gs......ss.shhhtsss.........t........................h....ltshhpps.tshh.shs.psh..sth.spoDahsFh..ttulPul...phtsst..................hsttY.HospDshsp..lshsuh.p	..................................................hllluuHhDohs.........................................................hssG.A..s....D............s..uoGs..............uslL.E....lA.+....h....lt......p.........t..hp.........pp..................................................................................................slhFhh...as...u.EE............................................................................tG.L..h.G.....Sp..tasp.......t..tpt................................................................................................................t.p.p.h..h...h.hlNh....D.h.....h.........us.............sst.t.h..h..h.t.sss.....................t..t.....................................................................hpth..h.p..p.h...h.................h.....h......p.........t.....h.......s......h.......p......h...............................t...t......h......h....s.....p....o......D..a...h...sFh..............ptG.l...P..s..h....th.htss...............................................................s...ha...H...s...t...Dsh.pt.ls.....h................................................................................................................................................................................................................................	0	912	1571	2227
+694	PF01551	Peptidase_M23	Peptidase_M37;	Peptidase family M23	Bateman A	anon	Pfam-B_291 (release 4.0)	Family	Members of this family are zinc metallopeptidases with a range of specificities. The peptidase family M23 is included in this family, these are Gly-Gly endopeptidases. Peptidase family M23 are also endopeptidases. This family also includes some bacterial lipoproteins such as Swiss:P33648 for which no proteolytic activity has been demonstrated. This family also includes leukocyte cell-derived chemotaxin 2 (LECT2) proteins.  LECT2 is a liver-specific protein which is thought to be linked to hepatocyte growth although the exact function of this protein is unknown.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.32	0.72	-3.94	276	16518	2012-10-02 20:27:15	2003-04-07 12:59:11	17	180	4065	22	3908	13013	6175	97.80	32	25.05	CHANGED	phHp...GlDl....uus.....h..Go........s..VhAsssGpV..hhuuh.....t.....uh.GphlhlcH...ssu..hhohYuH..hsp.hh..Vc..tGppVppGphIGtsG.sTG..............uo...GP............HLHF.El..p.h............su.pslsP	..........................................................................t..HpGlDh...........us.s..............t...G.s................s....l..h..A..s.s.s....GpV.........sh.ss........tt.......................................ua..Gp.h.l..hlcH...................sss....hhohYuH........h..sp..hh.................Vp.................G.p.p...V....p.t.Gph..I..uhsG..soG.....................uo..........us...........................HLHF.El..p..h.............ps..p.lsP...................................................	0	1317	2602	3339
+695	PF01434	Peptidase_M41		Peptidase family M41	Bateman A	anon	Swiss-Prot	Family	\N	20.60	20.60	20.60	20.60	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.37	0.70	-4.86	31	7039	2012-10-03 04:41:15	2003-04-07 12:59:11	13	33	4736	42	2254	5669	3966	203.00	39	31.13	CHANGED	ohp-l--AlDRlluGhE++.shllopcpK+llAYHEuGHAllGhhhcssDPVpKVTIlPRGp.AhGhThhlPc-Dph....ho+ppLhsplssshGGRsAEEllFG..clTTGAusDlppsTplARpMVTcaGMScclGslshtppss.t..hh.tht.tptaScpTuphIDpEV+pllccuYc+ApplLpcp+ctl-tlActLL-+ETlcu--hppl	.........................................................p..p-h-cAhD.+l.l....h..G.sE.+.+..o.t..l........h..o......ccE+..c...............hsAYHEuGHAll....uh.....h............l.....s.....p.....s............-......P.....V.........p..K.......V.....T......I.....l....P....R....Gp.....A.......L.......Gh......s...h..h...L..P.........c.....c..D..phh........ho+............p..p...........L.hs...............p.ls.shhGGRsAEEllaG.................cloT.....G....A....S....N....DlcpATp....l.AR.sMV.....Tp........a...G..M.....S...-..c..l.G..sl...ta...s.p.p.......ps...........................a.....h...h...t.....s.......h......t.................t.........p.......p.................s.hS-...p...TA..p...h.ID.pEV....+pll..ccsYpcApplLp.....c..pc................-t.lc...............tluctLlc..hETlsucplppl..................................................................	0	790	1454	1932
+696	PF02163	Peptidase_M50		Peptidase family M50	Bateman A	anon	IPR001193	Family	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null --hand HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.09	0.71	-5.34	68	8451	2012-10-03 04:41:15	2003-04-07 12:59:11	17	49	4572	15	2487	6748	4385	283.10	20	78.45	CHANGED	hhllulhlhls.lHEhGHhhsA..+ptGl.plpphthhhG.hlhthh.ht.h.h............................................................................................................hssshphphtptshhp+hhlshAGPhsNhllA.llhhhlhhhhss...............................................................................................................................................................................................................................................................................................................................................................................................................h.............htsshhthhhhhuhlslsLulhNLlPlssLDGG+llh.hh.............hh.tt.hs.phtthhhhhshslhhhhhhhshhps	.......................................................................................................................................................................................................................................................................................hhlslhlhlh....lHE.hGHhh.sA......+h.h.Gh..pst.ph..t......h..t..h..........u..................l.......ht..h............h............................h.............h........h......t.h.h............h.....h....h.h.....h............h....h.s................................................................................................................................................................t...........t..h..t....h..tp..ps.hh.p.+.h..hl.hhA..GPhh.N..hl...l.u.l...l...h...h...h...h....h....h....h...h...t.s...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.t...s...h...h........h.l..h......h....h....u....h....l....s.l.s..L....u.l.hN....L....l.P.......l.....P.....s....L....D.GG+llhhh.h.........................t.h.h.h.....t.p..........h.............p.....h...t..t..h..h....h...h..h.s.h.hhh..hhh.hhh............................................................................................................................................................................................................................................................................................................................................................................................................................	1	901	1712	2148
+697	PF02897	Peptidase_S9_N		Prolyl oligopeptidase, N-terminal beta-propeller domain	Griffiths-Jones SR	anon	Structural domain	Domain	This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see Pfam:PF00326), excluding larger peptides and proteins from proteolysis in the cytosol.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.28	0.70	-5.90	30	3044	2012-10-05 17:30:42	2003-04-07 12:59:11	10	23	1955	38	1041	2696	2777	371.10	22	55.84	CHANGED	Psst+spttspph+Gpp......lsDPYtWLEDsc.....us-spAaVcApNphTpshLsph.sh+stltcclpphhshs+hosPa+cGpaaYYh+NsshpspsVlhppsss......pups.............cVhLDPNsLSc-G...TsulpshuhSpDGchlAYulstuGoDhhsI+hhclcsu..........................c.lsDsLcpVKaos.lsWssDscGhFYssaspspcsp.......pths.ppKlaaHtLGTsQSpDh.LlaEts-psp.hhhusplScDG+Ylllustpuss..NclahtDlppp..........s.hhphhhllsphcuphthVspc.......GsphhhhTN......csuPNh+LlssshssPs..pWcs.......lls-+ccclhh.shsltusaLllsYhc-spsplphachs............sthhhcphhhslGolsuhuuppcssclaapFoSahoPsslYch-hssschchhphp	.........................................................................................................................................................................thaG.t......h.Ds.YhW.........Lc....D......s............ssc.shsa....l.p.tcNths.p...t.h.h......s..p.........................s....hp........cp.lhpch....t...s...........h...h..p...t...p..c....h...u.s.....P....h..........h....c....s...s........a..h.Y...h.th.h.p.s.....s...p..p...sl.h..hRpssh.............tt.t......................................cllL.....D...s.....Np.....h....u.......t...s...p..........t.....ah.h.....h...t...uh....s....l..........o.......s.....D....s.......p.......h..h......A.........hu.........hs...h.t.Gs.-hh.s.....l.+hhclp.o.s..........................................................ph.h..s...-.....h.....l....p.....t....s.p....s..s..........hsW....s...s.D.....s....p....s......h..a.Ysp...hct..t................................................sh.pl.a.h..H..pl.......G.....o....s...ts...p......D........h...ll....ac.c.....p.....-.....s.....s.....h...............hh........u......h.......t......t........o..p.....s......p...c.......a...........l..h.......l..p..h.s...s...tss.........s.c.l...hh..lchpt...................................tsp..hhl..h..s.c.pc....s.h...th...l..sph...........tp.p...h..a..l.....hoN.............pp.u...s..h...t...l...h....p...s.....t.....h....p....s.......t............p.hp.......................lh..cpt.h.....h.....l.....p......s..h.......s.h......h........p..s.......a.l.....l.lp...h.pp.s.hs.pl.ph..hshp..............................................tth...hh.p.........h.......s...h......h......................h....s.....h....s.......s.....c...........c.....s.....sp...lh.hsa..oShssPs..plachsht.s.t.p.phh...t...................................................................................................................................	0	356	649	859
+698	PF04080	Per1		Per1-like 	Wood V, Finn RD	anon	Pfam-B_12918 (release 7.3);	Family	PER1 is required for GPI-phospholipase A2 activity and is involved in lipid remodelling of GPI-anchored proteins [2].	21.50	21.50	22.40	28.50	20.40	21.30	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.05	0.70	-4.97	34	346	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	246	0	231	344	0	246.10	35	77.58	CHANGED	pp.P..lhh+hhhWsC.u-CcYp.Cp..phhTppRhpp.s.....tls............................................QFHGKWPFhRl.....hGhQE.hSslFSlhNhhspap.Gh.tphpc.pl.pp.shpph...........alhhuhluhsAWhaSslFHsRDhslTE+LDYFsAuusVLhuhahshhRhhpL......pp.thtthasssslsh.assHlhhL.hhcaDYsYNMtsNlshGllQhllWhhauhhphpphtp.......................................................aslhPhllllhshhuhuLElaDFPPhhh.hlDAHuLWHhsTIs.shh.WYsFhlpDhp	..............................................s...PlhhphhhWsC.s-CcYp.C...hhhspthhpp..s.......ls............................................QFHG.KWPFhRh....................hGhQEPhSslFShhNhhsphh.sh.hphhp....l..tp...sht.h............................................ahhauhluhsuWhaSslFHoR.DhslTE..+LDYasAs.uhllau...lahshlRhhpl................................pp.thhhhhs..sh....hlhh.hssHlh.YL......p..h.h.caDYsYNMtsNlshGllphlhWhhash....h..ph....pth............................................................hphh..hllhhhhhuh.LElhDFPPh....hh...hlDAHulWHhsTls.shl.aa.sFlhcD...........................................	0	71	128	191
+699	PF04695	Pex14_N		Peroxisomal membrane anchor protein (Pex14p) conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4121 (release 7.5)	Family	Family of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes.  Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deletion analysis of this conserved region implicates it in selective peroxisome degradation. In the majority of members this region is situated at the N-terminus of the protein [1,2].	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.94	0.71	-4.12	53	413	2009-09-11 00:50:26	2003-04-07 12:59:11	8	13	263	4	278	398	0	121.40	28	31.63	CHANGED	sRc-LlssAlpFLpDssVpsoP.lp+KlpFLcSKGLop-EIctALpcussss.....................sspshsssssssshtssssss............hp............................sss.....................................sW+DhhlhssshuGlsauhYthsc+YlhPhl	............................R-pllpsAlp........FLp.......csp........VpsuP.ltp+hsFLcsK.....GLTp-EI-tAhpc....sssss.........................................st...ss.....s......ts..s..s......................h..............................................ss.......................................sacchhhhs.hhhuGluhuha.hh+phlhPhl...................................................................................................................	0	88	153	229
+700	PF00294	PfkB	pfkB; 	pfkB family carbohydrate kinase	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This family includes a variety of carbohydrate and pyrimidine kinases.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.75	0.70	-5.29	64	26513	2012-10-03 06:25:16	2003-04-07 12:59:11	19	81	4887	268	6104	23264	9854	285.90	18	86.51	CHANGED	hstlsslGts...h-hhhhs.t..........thh.pstphphtsGGsutNsAhslupLG....hpsshlutlGsDphGphhhptlpppslssshhhhssp.pposhshhhhsts...ppslhhhhssssphpht...........hltpsphlhluu.....hhsts....tshhpthtphtcpts....s.shhsshht......hhpthpchh.shssllhsNccEhphhhstp...........shpphhphhtp....th...phlllThGs....cGshhhp.................pstththssh...thplVDTs..GAGDuFsuuhlsslhp..........stslccslphusssuuhslpptGsts.s.h..ph	...........................................................................................................................................................................................h......hG.h....hp..h.........t.................t....tstp.h.p.h..t.s.GGsuhNhA.hs.h.u.p.LG...............................tpst...h...l..u.h...l...G.............s..............D........t...h..G.p........h..l.h..p.t....l..p.....p........t..........u....l.........s.....s............s..h.....l.....h...h.........t.....s......p.....t..........t.......o.........u........h...t......h...h..h....h......s.....tp....t...........p......p........p......h.......h....h.............t....s.........s....s..s...p..h..p....t..................................t..h.l...t...p......s...c........h....l..h...hsu.........................h.......t.h...s...........p...h..h...p...t...h.........h.....p....h..t..p.pt.s..................s.s..h.h.s.....s..hht.........................t.h.....h...t.....p...h....l....tt.s....s...........l........l...h...s.........N..c......p..........E..h....p..h..l..h.u.hp......................................................s.pp..h..h..p..t..h...p...t......................ss...........ptl..l.....l.....o.....h........Gs....................cG......s...h...hhp...........................................................tst...h.h..p..h..ss.............t........s..p...l....l......D.......o...s...........GA...G......Duah.uu.h.l.t..u.l.hp.................................s.t..s..h..t..c.u...h...p...hA....ss...s....u......uhslpphGs.........t..........................................................................................................................................................	0	1886	3711	5053
+701	PF00169	PH		PH domain	SMART	anon	SMART	Domain	PH stands for pleckstrin homology.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.45	0.72	-3.82	133	16347	2012-10-04 00:02:24	2003-04-07 12:59:11	24	818	416	205	9216	15741	151	107.30	17	13.94	CHANGED	hhtpGhLhpps.........................ttppacc+ahhLps.......stLhhacspp....................................................................ttp.pttlsLpsh.plppssst.............................................................................ppptsFplttspp........................tphhlpssop.p-tppWlpslppshp	...................................................................................................................................h..hpGaLh+ps...................................hhps..W..c.c......Ra.hl..L..ps.........................st.Lh..a.acsp.p..................................................................................................................................................pp.p.s..p.s...t...l....s.L....p.....s.h....p....lptsspt....................................................................................................................................................................................................ppphs......F.p...lhstpp.................................................sh.hl...p.....A.....p..o...p..p-....h..p..pWlpslpp...t................................................................................................................................................................	0	2389	3501	5912
+702	PF05065	Phage_capsid		Phage capsid family 	Finn RD, Bateman A	anon	Pfam-B_3186 (release 7.7) & Pfam-B_9481 (release 10.0)	Family	Family of bacteriophage hypothetical proteins and capsid proteins. 	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.98	0.70	-5.21	189	3200	2012-10-03 06:22:39	2003-04-07 12:59:11	8	11	2039	63	462	2535	684	261.30	16	68.16	CHANGED	GGhllPpph.tsplhpthpptss.lpplssshs..ss.ssphph.hspss..............tushhu.....E...............tt.....spsss..phs.plsh...sscclsshh.tloppl..LpDushs..lp.sh...lssc....lspthutpcstshltG......ss...pstGhh......................hthssh...sssst..............h..............-slh....phh..slpsshp...t.ss....alhspssh.stlc..phK...D.ssGp....hlht...ssh...tssts......plhG....hPlhhspsh.............t.....................lhhG.Da....pshhlsc.....cts.lpl..hps......................s..ppshsthhshpRhssslhc..s.pAhth.hph	..................................................................................................................................hlstph..ppl.hp.hpppss..lt..p..hsphhp....ss..tt..phph...httts......................sushss.........E................................sp.....spsps....phs.pl..sh...sh.t.c.l......s.s.hh..tlo.p.c.l....lcsu..s....hs.............lt.sh........ltst..lsps...hstt..cp...sh....lpG.......................ss.....p.....shGhh...................................................thssh.....ssss.................s...sh..................................................................................cslh................shh.t....tlps.shp..............t.su........hlhssssh...ttlp...phc........s..ssGp......hlh...............s.h............ttsts.....plhG...........hslhhspth.........................................................................thhhG..sh....pthhl.sp.........pts..hphth.pp..........................tps.hh.hhstth..hshthhp...pAhhhh........................................................................................................................................	0	140	299	389
+703	PF02899	Phage_int_SAM_1	Phage_integr_N;	Phage integrase, N-terminal SAM-like domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.78	0.72	-3.83	37	10422	2012-10-02 14:21:04	2003-04-07 12:59:11	12	29	4035	13	2334	8796	3027	83.20	22	26.81	CHANGED	lcp..ahpaLthc+shStpTlpuYppsLpthhpahpp....thtshppl...stpcl...p.talschtpts........hsssolsp..tluulRsaapa..hhpcs	...........................................pt.ah.ph.L..h..h.c...+..s..h..S..tpTlp.uYppDL.........pp.hh..p..a..........lpp.................th.....h.....s.......h...p.....p..l...................stpsl.....................p.sa.l.s.p....h.tpps................................hsssohsR......ploulRs.Fa.p.a.Lhpp................................................................	0	747	1479	1975
+704	PF04860	Phage_portal		Phage portal protein	Kerrison ND	anon	Pfam-B_6050 (release 7.6)	Family	Bacteriophage portal proteins form a dodecamer and is located at a  five-fold vertex of the viral capsid.  The portal complex forms a channel through which the viral DNA is packaged into the capsid, and exits during  infection.  The portal protein is though to rotate during DNA packaging  [1]. Portal proteins from different phage show little sequence homology, so  this family does not represent all portal proteins.	27.90	27.90	27.90	28.20	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.93	0.70	-5.78	127	3192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	1991	3	469	2728	646	315.20	19	80.95	CHANGED	ht.st..ssh..tls.tpsshp.tssla..uslph.lupsluphPltlhcp....t.ttp.h.t....pslhpllp...pPN........ouhpahpthhhphlltG.Nua.shhhh..s......s.up..hh...p...Lh.lpspp.h.................ht..ss....phh.Yphp...........ss......tt...t.phstscllHl+.h..hshs.....shhGluslp.sutpslslshusppastphapNGspsuullphs..sth....sp..-phcp....hccphpp.thpGsssss...pshlLps...............G.hcapsl.....shssp-sphlp.s+phshc-IuphatVPsthluthtp.soh..usl-ptshsahphsLhPhlpphcpplstpLh..t.tthttthhhcFshpsllcs-.tsphphhtphhpsu....hho.N.EsRth.s	..................................................................................................................................................ht..........t..pshht..ssl...sslph..lupsluphshhhhcp..................................p.lhthhp....cPs...............suh.phh.pthhhp.hll..hG..Nua..l.hh...p....s..h..............t.Gp......sh.p.......Lh.h.sph.s................htstst.......................phh..Ythp............................................ts...................pt.......thpht.p....cl.lH.lp.s......h.p......tl.h.G.....hsshh.sshpsht.hstusppaptphapNG.u.p.suh.ll.h........stl....................sp...cshpp.........l+pphpp..t...p.G.....t..stt....+shhlps.....................G.h..chpsl.......s...ss..tc.sph.hp...hcphs...tc...c...ls....t....saplPst.hl.u...hh..s..p...ss...........uslEptst.sahpt.sl.hP.hhp.phpptlsp.hLh..................t.......hhcFs....sh..h..ths....t.ht.....h....hht..s.......hhs.s-hR.......................................................................................	0	123	284	381
+705	PF05119	Terminase_4	Phage_sml_term; 	Phage terminase, small subunit	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	24.20	24.20	24.20	24.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.00	0.72	-3.85	76	1248	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	969	0	185	864	92	98.70	21	66.43	CHANGED	A+ppW++lss.LpchtlLsphDhssLttYCpsYupahpspcplpc........pGhh.........hpstsG................thppsPhl.shhpcshpphpphusphGLoPuuRs+lsh....spspcscs	.............................tt.apchh..L.p.p..h..sh.lsthDh.thlptY...spsashapps...pcplpp.........pGhh................hpspsG...........................shtps.Phl.shtpcshpphpphssphGLossuRt+lhh.....tttt...s...........................................................................	0	56	117	162
+706	PF03354	Terminase_1	Phage_terminase; 	Phage Terminase 	Finn RD, Mifsud W	anon	Pfam-B_3931 (release 6.5)	Family	The majority of the members of this family are bacteriophage proteins, several of which are thought to be terminase large subunit proteins. There are also a number of bacterial proteins of unknown function.	19.70	19.70	19.70	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.45	0.70	-6.08	7	2382	2012-10-05 12:31:07	2003-04-07 12:59:11	10	9	1576	0	301	2092	481	410.10	22	80.19	CHANGED	PaQcFhhs.haGW....cptsss+pFscshhpluRtpGKohhhAhhslhphhlt..GpsstphhlsuhshcQAtclF...............p.stp.h+t....p..hphh.c.cl.tsppptl.hhh.pshh+hhospssphDGhp.phsIhDEhtphpscphspplhpG.ht..tN..hlhI.oTussshsu.hc-chchhpphh....phpsDsaashlap.Ds.--shDsppWhKuNPhLshs.phcslhcshptstsssh....phscFhsKphNLWh.pcossahshpsh-p......hs.hshpG+csalGlDhShhsDsTAlshla.htG.....+hahcshoFhP.tsttt...t..pptt....pYpphhppG...hphpssuhIs.pplhshlhpahppp.hplpthuYD...shtsp.hhsplppp.hsh...shhclpQshtshusshKhlpphhhpp+lp+sss.lhphtlhNsshKhDshs.lphsKcts...stKIDsssAlI.AhhpAhhst.	...................................................................................................................................................................................................................ap..h.hhst...la.G...h...................t.p.t.....s..t.h....+h.a..p..c..shl.l.sR+sGKo.t.lh.u.sl.h.h.h.hh..h.hp..................sp.....s.t...c...l...h...h.s...AsspcQAphs.F....................p.s....pp..h.l.pt.................s...h.p.........h................p....h......................t.....p..p...l.........h.........h........t...s....t..u.....h..hp..h.....h..s....s....s.s.p.s.h.cGh.p.s.t..h...slhDE......h....+....t..h......t.........s.........p..........p.......hh...p....s....h....ps....Ghut...p...ps......h..hhh.I...oT..u..G.....s.....h.p..u....h.h.p...h.h.p.h.s.t.......p.......l...l......p..........t...................................p..........h..............ps..............s.....p.ha.s...h.l......h.....p..........h......-...........c.................t..........c................-.............h..p.......c.......p.s......W....h.....+.AN.....P....t.l.....s......h...s...h....t........h......c.t.l...h....pp.hpp...s.p...p...s.st................th.tt...a...hsKphN..h..h..h......t..t..p....t....s.ah.sh.....pph...pt................h....h...s..............p......h.......p....s.....p............s..h....h.........G.l.Dh....up.hpDhs..u..h..s..h...h..h...........p.s...................ph..h.h..h.s.h.....a.h.s..pt...h.p.................pp.p.............apt...a....c.......t.G.......h...lph.s.t...s...s...h...l.c......ht...lh.p......hhh.....p...hhpp.........................h....l..p..t..l.shD....h.ts.t.t.h.h.pt..l.p..p...s.h.............................hh.th.Qs...........h........p...................h......sss........h...c...p...hcphh...............h.............pt..p..........l..ha.s..s...........sPlhpWhhs..Ns..hh.c......c......s.s.s......h...h...sK...p.p.p....p.pK.IDshhAhl.Ah........th.......................................................................................................	2	82	188	254
+707	PF00628	PHD		PHD-finger	Pascual J, Bateman A	anon	Prosite	Domain	PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2].  Several PHD fingers have been identified as binding modules of methylated histone H3 [3].	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.96	0.72	-4.27	92	10006	2012-10-03 17:27:21	2003-04-07 12:59:11	24	581	416	151	6059	10034	80	49.80	31	6.20	CHANGED	hC.lCpp.............ssphltC..-..s.Cs.psaHhtCls.shp..ph.pt.........tWhCspCpsp	...........................hC.lCpp................tt....ssp..hltC....D............p..C...s...phaHh..tC...ls..s...hp.........p..hsps...................pW.hC.s.p.Cp..t..............	0	1693	2722	4372
+708	PF01384	PHO4		Phosphate transporter family	Bateman A	anon	Pfam-B_923 (release 3.0)	Family	This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter [1]. This family also contains the leukaemia virus receptor Swiss:Q08344.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.01	0.70	-5.78	174	5075	2009-01-15 18:05:59	2003-04-07 12:59:11	15	11	3412	0	1413	3524	1377	368.90	29	86.21	CHANGED	hGuNDsANuhuTuVuo+slohpp.AlllAulhphlG....Alhh.....GspVspTIsp.sllssshh....................................................shhuuLluuslWhhlushhGlPlSooHullGullGsulsss.....G...h........................ss...lpWs.......................................t.lhp...IlhuWllSPlluh.hluhllh...hhlphhhh..........t.h......................................hhh.........................................................................................................................................................................................................................................................................................................................................................hpph.......aphhtlhoushhuFuHGuNDsupulGslsshhh............ts.h...................................................................................................................................................................P.................h..Wl......llhuuhululGhhhhGh+llcTlGpcloc..lssspGassphuuAhslhhAoh.........hGl......PVSoT+slsGulhGlGhsc..............................................................................................t.hp..slph...phltpIlhu..............................................WllTlPh.....uullu	.............................................................................................................................................................................................................................sGhpDsANuhATslu...............o+ulp.s.ph.Al.lhAulhshhG...........shlh..............G..s...p.VutT.Itp.sl...s.s.s...hhs.................................................................h.hhhh.usLlu..AhlW..lhshhhGlPsSoo..Hu.....lIGullGsulssu.............u....h..............................................su.lshs..............................................................t.lhp.........I.hh.........uhllSPll.uh.l...hu.hll.h....hllcthh.h.................th..............p.h..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pspph.........ap.hh..l.hoA.shh...uFuHG...uNDsppuhGhlh.hllh...............ht......ssh..........t..................................................................................................................................................................t..sP............h..Wl..h..hh.sululu.lGshhh..G..h+lhpTl.GpcIsc..ls.s...p..G.huAphsuAhs.l.h.h.Ao.h...............h.G....h...............PVSTTHsls.uulhGsGhsc..............................................................................................t....t....ulph.....tssppllhuWllTlPsuullu...........................................................................................................................................................................................................................................	0	437	853	1191
+709	PF01663	Phosphodiest		Type I phosphodiesterase / nucleotide pyrophosphatase	Bashton M, Bateman A	anon	Pfam-B_994 (release 4.1) & Pfam-B_6150 (Release 8.0)	Family	This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD,  deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which  exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form  F. odoratum [2].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.38	0.70	-5.13	70	4764	2012-10-03 20:55:17	2003-04-07 12:59:11	17	83	2021	34	2144	12839	5667	283.30	14	54.15	CHANGED	llllulDGhpschlpc.........tthPslppL.........hppGspst..hpssaPohThPsahollTGhhPspHGIluNphhD...........................................sppptp..athp.....shpsh............PlWhssp.cpshp..........sushhaPuspsshss......................Pphh..phhstp...hsh......................................................ptchsphhp.hhch..pscc........sslhhhah....ppsDpsG.H......................paGs..s..usc........hpp......slpclDphlupLhpsLccpth.tpssl.lllS.........DHGhsss....................................p+hlh...........lsph...........hs.sth...............hspsslstlhsp.............................ttthsclhptLpsh...........tthpshh...cp...phs.tchpht..........................spRhsslhlhscsGhhhhtpt................ttph..thtGsHGac	.............................................................................................................................................................................................................................................................................lhh.hD..u....h..t......t....h.....................h.s.h..t.t..h...............................h.p.p..u.h....h...............h..............s...............h..........P..........o.h..o...h..s.s...h..s.lh....T..G......h..h...........s...t.........p....G......l...h..t..........h.h.......................................................................................................................................h...............................................................................shh....t...t...................................ss........h..............................h.......t....................................................................................................................................................................s........h........................pt............h...................................................................................................................................................................................t.h..s...p....h..h............h.h.t...t.......h.....t...p.pp...................................s..h.h..h...h........a.h...........................t.h.......D....p....h.G...H.......................................................................................................................th.Gs.......p..........u.p....................................................htp.............................tlp.p.h...D.p...h...l...t....p.l....h......p........t.l.....p........p...t.............................t......h.......l.ll.su................D.....H...G..hssh......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	703	1239	1744
+710	PF02811	PHP	PHP_C; 	PHP domain	L Aravind, Bateman A	anon	L Aravind	Family	The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null --hand HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.25	0.71	-4.48	69	14520	2012-10-03 00:45:34	2003-04-07 12:59:11	14	119	4828	48	3478	11535	3589	213.50	16	29.40	CHANGED	h-LHsHopaS.......DGts.slc-hl...cpAtchGhp....slulTDH..sshhs...shphhpttpt..............................hs....lp....hlh..GhEhpls.t.....................................................................................................................................................................................................tpt....htt.hchhlhuh.pt................................plsphtshthh.................................phlpph......ppshlslhuahpsththh...............hppscphlpth...................................ht.pshhhElpspth.t.......................phpp	................................................................................................................................cLHsH.o.....s.h.S....................DG....h.......h....s...h.......p.....c.....hl..............pp.At.p.h..Gh.p....slAlTDH.................ssh...h.u.................h.s..c.h...h..pt.spt........................................................................................ts......lc........hlh....GhEhthh.................................................................................................................................................................................................................................................................................................................................................................................................................p...t.tt...h...c..h.h.l....h.u..h...p...p......s.ht..................................................................................slhp.hhs.t.t.hh.........................................................................h............phlt.th..................ppG.h.l.h.hh...u...p........t...t.......h...h...h.............................................................h...t.hht.h..............................................hhpl..................tthtth...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1312	2409	3037
+712	PF02972	Phycoerythr_ab	phycoerythr_ab; 	Phycoerythrin, alpha/beta chain	Griffiths-Jones SR	anon	Structural domain	Family	This family represents the non-globular alpha and beta chain components of phycoerythrin.  The structure is a long beta-hairpin and a single alpha-helix.	22.50	22.50	23.60	53.00	20.80	17.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.77	0.72	-4.37	5	25	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	4	6	0	31	0	56.60	54	46.87	CHANGED	+APVITIFDHRGC.SRAPKEYTGsKAGGpDDEMCVKVuMsKlpV...SEusAstlLpEhLu	.+APlITIFDHRGC..uRAsKEYTGuKAGspDDEMhVKVtusKlpV...SpusAsthLpphlu...............	0	0	0	0
+713	PF05023	Phytochelatin		Phytochelatin synthase	Wood V, Rawlings ND	anon	Pfam-B_9299 (release 7.6)	Domain	Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols [2]. The crystal structure of a member of this family shows it to possess a papain fold [3]. The enzyme catalyses the deglycination of a GSH donor molecule [3]. The enzyme contains a catalytic triad of cysteine, histidine and aspartate residues.	23.80	23.80	23.80	24.00	23.40	23.70	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.33	0.70	-5.37	20	280	2012-10-10 12:56:15	2003-04-07 12:59:11	9	7	183	4	123	295	16	197.80	39	55.01	CHANGED	shsuhhppsLPs.shlsFuSsEGccLhtcu...ushcsaasLtspF.TQspsAaCGlASLsMVLNALu...............lD....PscthcG.PaRaFopssl.......pspshtc........lpcpGlTLsclusLu+sp..usslcsa...........................+us.chSlspFRpplhpshsssspalIlsYpRpslsQTGsGHFSPlGGYcttpDhsLILDVARaKYPPaWVshphLapAMpolDs.soucsRGahLIs	..................................................................................................................h......h.lst..hlthsS.tGpphh.pu.......sthpsaapLhs.tFpTQspsuaCGlAoL..........shVLNALt................................l-.....Ps..cta.c..u...PW..RaFspshLt..............sspshpt............lcp.pGlohsc....lssLApss........Gspspsh...................................+ss..ps.o...l.-pFRphlhp......s..s................s.......s..s.........s..........p.alllsYpR.ps.....l.t.......Qs...G..............s....G...H....F............SPlGuYcttp.D............hsLILDVARaK.YPPaW.Vsh.phLacAMso.hD.t..so.s.ptRGahll.........................................................	0	64	91	107
+714	PF02567	PhzC-PhzF		Phenazine biosynthesis-like protein	Mian N, Bateman A	anon	COGs	Family	PhzC/PhzF is involved in dimerisation of two 2,3-dihydro-3-oxo-anthranilic acid molecules to create PCA by P. fluorescens [1]. This family also contains Swiss:P28176, though there is no significant sequence similarity to Pfam:PF00303 members. This family appears to be distantly related to Pfam:PF01678, including containing a weak internal duplication.  However members of this family do not contain the conserved cysteines that are hypothesised to be active site residues (Bateman A pers obs).	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.87	0.70	-5.19	14	3486	2012-10-03 03:02:41	2003-04-07 12:59:11	11	19	2256	24	972	3693	843	247.90	26	93.31	CHANGED	lDAFTspPhp.GNPsuVsh.s-.....pls-stMQplAsEhshSETsFlhhss........pssch+lRhFTPssElshsGHuTluouhsLhppsh......ssspl.hpThuGhlss.............tppssstphhlphphPhhshhshsptt.s.h.hhhths................sh.hthtssGhtplhlsLpShculsslpPch........p.htchsstuhhshsstsssustcapuRhFu.PthGlsEDPsTGSAsssLutYLspchph.......phplhQGpu.uRsGplphph.....c.t...p+VplsGpAVslhcG	......................................................................................................................................................lDsF..o..s.p..s...ht..GNs.su.Vlh...sp...................L..s...c.t.p.MQtI...A.....p.-...h.....s....h......S........ET......s......F..lh..t.s..................................t.ss....sh......c.....l..Rh..F.T.P.p.t.E.lsh.sGH.sTlusu.h.s.lh..phht......................tssp.l...hh.ps.t.u.G..h..ltl.....................................................t....t..t.th..h..h.p......s....h....P...t...h.......t...s................h.......s.....t....t....t.....h....t...h....h.......t..h.h.h..p...................................h..s.t.h.h.s..s.G.......t...t..l..h..l.......l.p.....s....t...t....s...l..t......s..l.....p....P.sh..................................th.h..t...p...h.....s....t....t......s.....h.....h...s........h......h..........h........t.......s......s........t.......s.......t....t....c...........h..hu..Rh.F..s...P..t..h.G..l......s....EDPsTG.oAsus..l..u.s.a..hh.p...p..h.hh...................................h.p.h..pQ.G.p..t.h.s..Rsu..hlt.splt.............................tp........l...h...lu.....Gpuhhh.......................................................................................................................................................................	0	306	597	824
+715	PF00454	PI3_PI4_kinase		Phosphatidylinositol 3- and 4-kinase	Sonnhammer ELL, Finn RD	anon	Prosite & Pfam-B_6771 (Rlease 7.6)	Family	Some members of this family probably do not have lipid kinase activity and are protein kinases, e.g. Swiss:P42345 [1].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.34	0.70	-4.90	43	4451	2009-09-16 22:35:53	2003-04-07 12:59:11	22	163	790	95	2750	4248	185	225.50	21	15.05	CHANGED	th..hhhKsG-DLR..QDthhhQhl...........................plhsplhpp-shshc.......lpsYtllshusptGhlp..................hlsss.ohtpl..tpthhptth................................................................sslhphFhcpssss.......tpahp................................................................stppaspShAshsllsYlLGluDRHssNlhl......................................ptsGclhHID.................FGhhhs.....t..p.-psPFcLop........shspsh.t.....ssstphthF+phshpshphlRcstshlhsll.........phhhpsslhphpp	.....................................................................................................................................................................................t...hhhK..s..t.-..DhR.....pD.hhhQhh.........................................................phhp.pl..h....t.....p.p..s.h.s.hp............................htsY..t...llsh...us...t............G.......hlp........................................hls.ss.....sl..t........t....l............p..p..h.....h............................................................................................................................................................ssh.hph..h...h..p...p.....s..ss.............pt..a..h..p..............................................................................................................................................................t.pp..p..a...spS.........h....Ashsl.............lsYl.....Ls....ls...D.....R....H.ss..Nlhl.......................................................................................................ptsGc....l....hH....ID.................................................FGh.h..hs..............t...........t.....-ps.PF+LTp........................phhpsh.......................t.st......th..a..........p............p.......h..........s................p..........sh.......h...hR..p...p...t..p..h..lhsl.h.................phhh.ssh.t...t.........................................................................	0	1017	1545	2244
+716	PF00792	PI3K_C2		Phosphoinositide 3-kinase C2	SMART, Griffiths-Jones SR	anon	Alignment kindly provided by SMART	Domain	Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family. 	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.78	0.71	-4.41	24	929	2012-10-10 12:23:49	2003-04-07 12:59:11	19	41	276	79	559	820	7	139.70	21	12.87	CHANGED	sp.plhlpssla...tssc.Ls.....sl.poshsshs..........phsWs.chlsas.lphpsLPtsAhLslsla.....shptsppt....................lGhssl.LFsp.+shL+p.G.ppLpl.Wsstpsst.h.h.......................thppGphpp...sphlDthsh	..............................................................s..clhVpstla..pss.c..Ls........sl...pTphhshs.......................tphtWs..c.....h..lpa.s..lplscLP+pupLslsl.a...........s.l..stspst.......................................................hsluh......sslsLFs........h...cshL+p.G.phtLpl.Wssstsptt..........................................................................t....................................................................................................	0	172	248	399
+717	PF00640	PID		Phosphotyrosine interaction domain (PTB/PID)	Bateman A	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.75	0.71	-4.20	25	2909	2012-10-04 00:02:25	2003-04-07 12:59:11	18	102	112	50	1457	2821	2	128.10	21	22.94	CHANGED	Fts+YLGsl-Vsps......t..h..sp-Alpplptt.................ht....h..puptpph.pplhLplSscslplhssco.........ppllhsaslcpISahus..Dss.p.ctFua...............htctsspphtCHlFhspc....ApslupulGpAFpltapphLct	......................................................................................a.spaLG.hpl.p...............s.ppulpplptt.............................................st.t.p...ph...hpl.....h...L...p...l...o...h.p...s...lp...l..l...s..sps.......................pp..l.l...h..p..p..sl.p.p..I.Sa.h.ut........D...............p..p...............chFua..............................................................hs.p...c...t....s...s....p...p....hhCH..lFp..spp.............Aptl..s.s.ltpAF..p.hthp.h...t.............................................	0	345	463	898
+718	PF04987	PigN		Phosphatidylinositolglycan class N (PIG-N)	Moxon SJ	anon	Pfam-B_5307 (release 7.6)	Family	Phosphatidylinositolglycan class N (PIG-N) is a mammalian homologue of the yeast protein MCD4P and is expressed in the endoplasmic reticulum [1]. PIG-N is essential for glycosylphosphatidylinositol anchor synthesis. Glycosylphosphatidylinositol (GPI)-anchored proteins are cell surface-localised proteins that serve many important cellular functions [2].	20.80	20.80	20.90	20.90	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.54	0.70	-5.83	39	370	2009-01-15 18:05:59	2003-04-07 12:59:11	9	19	235	0	259	348	1	374.50	26	46.08	CHANGED	cGLcYLQTYsWhaLpsllThGalGWIsashstllchash.......ptp.......p.....................pohhshhhFss.lhlsLhhlhhhQ+SPhpYYhYhhFPlhFWpp............lhscppsltsuhp.hhtt.p......hhphlhthlhh.lulhEsl..VhuaFcRplholhahhhuh.as..hhhshthht..ppthhshhWhlsslhhosFoLL....sss+hcshphI.......hhuuhLhhlsuhhhlh......................tsphoppl......hshQlhhlllshhsTptoshSLps..+pGLPhhsQlsuWhhLlsSll.lPhh....ss.schhtRLhlIFLshuPsFllLoISYEuLFYhsFshpLhtWlplEptlhh.stt.t.................................................h+slslsDhRlulhahhhlpsAFFuTGNlASlS............SFsL-SVhRllPlFsPFs.GALLl.lKLlIPahllossLGllscpLplsspslFhlllslSDlMoLpFFalV+scGS	..................................................................pGLpYhpsYshhhLhshlshualGWhhhhhhhllc.hs...............p..........p.....................................tthhhhhhhhs.hhhhlhhhhhhppsPhtaahYhhhPlh.....h.W.t.........................lhtp.ht....hh.tt....h..h......h.t...............................h.phhh.hhhh.hhh..hphl.....lhuaa.R..hhohhhhhhuh.hs...hhsh..h......tthh.............hhWhh.shhhusFsh....h....ss.h..sh.....h.l.............hhuuhlhhh.hshhhh.................................................h.thphhl.............hhhphhhlhh..shh...........sh.thpt...p.tslPhh.plhuW..hhlh.uhh...hPhh.............................s.pthhtRLh..lhhshhssallLohuYEu..LFhhhhshhhhhWlp.........lEpthh..pt.................................................................pthhhpshRhuhhhh......hhh.suFFuTGNlASls............SFshsolhphlslF.sPFhhuuLlh.hKlhlPahll....sshthl...........shh.hphs...............tsl..................a..........hhlh.......hhoDhhsLpFFahV+spGS..................................................	1	74	129	213
+719	PF01850	PIN		PIN domain	Bateman A	anon	[1]	Domain	\N	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.43	0.71	-3.78	170	8807	2012-10-03 20:43:45	2003-04-07 12:59:11	16	13	2111	52	2682	7029	1235	121.10	16	80.11	CHANGED	hhlDTslllthh............pscsttthhtthhpt........tplhhsslsh..hElhhshpp..............................tttphhphhhh.htthplls...hstphhtpstclhtpht...........lshhDshhhAtA.......httsht.....ll.T.tDpc.......htchsth	..........................................................................llDTsll.lthh...................psp...s.t.t.t.t...h....tt.h.lpt..................tplhlssh..sh...hE.lh.hshpp.............................................t.ttp.h.hthhhh.....h....t..t....h..p....l.ls..........h.s.t.p....h.h....t..t....s.t.p...l...h.tpht...............................hshhDshlh.AhA.........ht...tshs...........ll.T.tD.p.c....htt....h...........................................................................................................................	0	858	1797	2312
+720	PF04696	Pinin_SDK_memA	pinin_SDK_memA; 	pinin/SDK/memA/ protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4141 (release 7.5)	Family	Members of this family have very varied localisations within the eukaryotic cell. pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque [1].  SDK2/3 is a dynamically localised nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing [2].  memA is a tumour marker preferentially expressed in human melanoma cell lines.  A common feature of the members of this family is that they may all participate in regulating protein-protein interactions [3].	25.00	25.00	25.70	25.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.86	0.71	-4.55	11	266	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	204	0	185	268	0	123.00	32	28.27	CHANGED	pDpcp+.tRNRRhFGsLLGTLQKFpQEpshh..spppc+Rs-IEpKl......EcQtctERcplccc+cpLap-R+ccQhElRtLEpKhtchc..cpWppp.thltpa.I+T.KTcP+laahPtphsspppKhLcEs.pc-sp	...........spct+.pRN+R.....hFG.t.L.h.G.TLp+Fpp..E..p..p.h.............op....ppc..RR....pEIEp+h......-t...ptcp.E....c.cp.l...c....p....c++....p..ht....-.+R....t.c....ph.plR..th.-p..ch...t.....t..p....h.h...c....php.pp.tthtpa.l........+.....T..+scP.l.........aYhPhchs.tspphlppp..pp..................................	0	68	102	150
+721	PF01504	PIP5K		Phosphatidylinositol-4-phosphate 5-Kinase	Bashton M, Bateman A	anon	Pfam-B_571 (release 4.0)	Family	This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in [1]. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the  phosphorylation of phosphatidylinositol-4-phosphate a precursor in the  phosphinositide signaling pathway.	20.20	20.20	20.40	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.86	0.70	-5.27	117	1752	2009-01-15 18:05:59	2003-04-07 12:59:11	13	60	323	8	1132	1665	41	260.10	28	29.93	CHANGED	hSL......ssp.....h.phsosGK..........SGS.hFahopDp+FlIKTl.p+...pEhc......................hhhc..hLspYap.alppssp.........................TLLs+h....aGlapl.........................p.....ss...pcht...........................hlVMpNlF....st..hplc.......cpaD........LKG.Sphs...........................Rpsp.............................t....p........tt.............sLK......Dhshhp.......phlhlstpp+phlhcplppDspFLpphplMDYSLLlGl....................+........................................................................................................................................thh...t..........................ptlhalGIIDhLppYs..hpK+lEphhKsh.hhs.t.....pslSslsPppYucRFh.cFlpphh	.......................................................................................................................h...sssG+SGu.hFaho.t....Dc+alIKol....p+.....pEhp..............................hhhc..hLs.tYap...a....l.pp.s..p.......................................TLLs+hhGlapl.............................t.h..su...pphp..................................................................h...l.VMpNlF............s........hph.p............................ppaD........L..K.G.Sphs...................................................Rpsp..............p.....pt.ptpt................................................tsshK..D.shhp...................phlhls.t.p.tp.phlh.cplpp.Dsp.....aLp........ph.plMDYSLLlGl...........c..................................................................................................................................................................................................................................................................................................................................................................................s......................pc.hha.hG.II..D..hLpp.Ys............h.pK+lEphh.K...sh.hhs..s........pphS.s.lsPp.YtcRFh.c.hhpph.......................................................................................................................................	2	374	629	900
+722	PF02171	Piwi		Piwi domain	Bateman A, Hammonds G	anon	Bateman A	Family	This domain is found in the protein Piwi and its relatives.  The function of this domain is the dsRNA guided hydrolysis of ssRNA. Determination of the crystal structure of Argonaute reveals that PIWI is an RNase H domain, and identifies Argonaute as Slicer, the enzyme that cleaves mRNA in the RNAi RISC complex [2].  In addition, Mg+2 dependence and production of 3'-OH and 5' phosphate products are shared characteristics of RNaseH and RISC. The PIWI domain core has a tertiary structure belonging to the RNase H family of enzymes.  RNase H fold proteins all have a five-stranded mixed beta-sheet surrounded by helices. By analogy to RNase H enzymes which cleave single-stranded RNA guided by the DNA strand in an RNA/DNA hybrid, the PIWI domain can be inferred to cleave single-stranded RNA, for example mRNA, guided by double stranded siRNA. 	19.90	19.90	19.90	20.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.82	0.70	-5.45	18	2067	2012-10-03 01:22:09	2003-04-07 12:59:11	12	30	421	62	1282	2033	12	263.30	32	35.31	CHANGED	hllsllsc.pspsh.YtslKKhhps-hsl.oQslphcshhph..........tphhsNlhlchNsKlGGhN..hhlsshsh.......pshh.........llGhDlsHsssup..........tssoluuhluohs.ppsspahussphpppsp-hlss.lpp............hltchLpsapcsspp.pPp+IllYRDGsuEGph.plhp.Elspl+cshc.......plspsap..PplshIllpKpppsRhFspstsp........................tt.Ns.PGTlV...DstlspPpth-FaLsupsshpGTs+Ps+YsVlhD-hthss-cl.QpL......oYpLsahahpsh....pslulPsPlaYAcplAttstpphc	......................................................................................................................................................h.hhhll..st...pt....h..Yst.lK+h..s.p...h....h..sh..........oQsl...p..p.h.p....................ph...hss.l.sh.......plNsK..........l..........GGh..........hhh..p.........................tssh..................................hl...GhDVsHssssp................................................ts..Slsu.......h...Vu.Shs.......p....s.....c....a......h.....u...p.sp...h.........Q...........p......t......p.....p.......E.........h.l......ps...ltt...................................................h.hpph.L.h...ta........h............p........t...........s....t........t..................h........Pp...+I...lhY....R...............DG.Vo-GQh.t.pl.h..p..El....t.lc...pu.ht........................p.h...t...........s..hp............Ptlohl.lVp.K..R..H..poR.......h.......F....s...t..stpp.........................................t.t.Nh..s......GT.l..V.......................Dp.t..l..s......p..P..p.......t......a....D..F.a.L.s......S..+..t..........u..h................p......G..T...u.+.Ps+Y..pV..l...h...D....-..........s.............p..........h..s...........s...D.....pl....Qp....L..................Tap.L.Caha.h.pss.................p.slsls..sPshYAchhuhhst......................................................................................................	0	440	645	1059
+723	PF00801	PKD		PKD domain	Bateman A	anon	[1]	Domain	This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold [1].	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.26	0.72	-4.23	93	5437	2012-10-03 16:25:20	2003-04-07 12:59:11	15	708	991	15	2785	5152	1955	70.40	22	13.50	CHANGED	hsss.........shhstslpFssps....s................Gssssap....WsFGD.......................stsssptsssHsYsp......................sGsYsVsLssssssussss	.........................................................s...........h..s.slpFssps.......s..........................us.s..s.s....ap.............WsFGD........................sssu.s.t..t...s...s...s..H.s...Y.sp.....................................................................sG...s.Ys.VsLol.ssshut...t.........................	0	1060	1676	2066
+724	PF01477	PLAT		PLAT/LH2 domain	Bateman A	anon	Bateman A	Domain	This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain.  The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners.\	The structure of this domain is known for many members of the family and is composed of a beta sandwich.	20.80	20.80	20.80	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.52	0.71	-3.70	84	3359	2012-10-02 11:40:54	2003-04-07 12:59:11	18	189	280	91	1790	3171	14	109.70	19	17.37	CHANGED	hplplh....utphtussst...h.h.lhs.spGcssphthhps.h............ssshphphch..t....slG.lttltlppt......................hps.paalppl.hltt.....hsst.sph.pFss......pp.Wltss.........phhhh	.........................................Yplhlh.T...ut...t.u.u.Tssp.......lhltlhG...pp..G...c...o..t...p.h.....l.h.psttt...................................tsstppF.p...l..ps...t........slG..p.l.t.plp.lt+c.......................st.shps..sW........alc..pl..hlps...................s.t....p.p..h...hFss.......pp.Wlstpp............................................................................	0	578	838	1202
+725	PF00614	PLDc		Phospholipase D Active site motif	Ponting C, Schultz J, Bork P	anon	Alignment kindly provided by SMART	Family	Phosphatidylcholine-hydrolysing phospholipase D (PLD) isoforms are activated by ADP-ribosylation factors (ARFs). PLD produces phosphatidic acid from phosphatidylcholine, which may be essential for the formation of certain types of transport vesicles or may be constitutive vesicular transport to signal transduction pathways.  PC-hydrolysing PLD is a homologue of cardiolipin synthase, phosphatidylserine synthase, bacterial PLDs, and viral proteins. Each of these appears to possess a domain duplication which is apparent by the presence of two motifs containing well-conserved histidine, lysine, and/or asparagine residues which may contribute to the active site. aspartic acid.  An E. coli endonuclease (nuc) and similar proteins appear to be PLD homologues but possess only one of these motifs. The profile contained here represents only the putative active site regions, since an accurate multiple alignment of the repeat units has not been achieved.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.70	0.72	-6.96	0.72	-4.02	48	1567	2012-10-02 13:01:53	2003-04-07 12:59:11	17	33	652	3	833	6708	176	29.50	40	4.30	CHANGED	hshhhHpKhlllDcc............hsalGuushsssp	........hhsHHpKhlllDsp.................luFlGGlDLs.tp......	0	219	475	677
+726	PF01690	PLRV_ORF5		Potato leaf roll virus readthrough protein	Bashton M, Bateman A	anon	Pfam-B_1335 (release 4.1)	Family	This family consists mainly of the potato leaf roll virus  readthrough protein. This is generated via a readthrough  of open reading frame 3 a coat protein allowing transcription of open reading frame 5 to give an extended coat protein  with a large c-terminal addition or read through domain [1]. The readthrough protein is thought to play a role in the  circulative aphid transmission of potato leaf roll virus [1]. Also in the family is open reading frame 6 from beet western yellows virus and potato leaf roll virus both luteovirus and an unknown protein from cucurbit aphid-borne yellows virus a closterovirus.	27.40	27.40	27.70	27.70	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.73	0.70	-5.34	14	317	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	35	0	0	332	1	377.50	41	71.26	CHANGED	VDup.PsPsPuPsPtP...PsPoPEPsPs.p+cRFhs.YsGsPpshIpsRpsoDuIsltslssQphpYIEDEshshpslsutWhosNslpA.PhFlaPVPcGpaSVpISCEGaQussshusspcGphpGhIAYsssss.csWNVGshssssITNh+usNoa+.GHPDLclNuC+FspsQlVE+DuhlSFHlpsssp-usFaLsAPslpKouKYNYsVSYGsaT-+cMEFGhISVslDEp..-utpsupcs+pshRsGHh.hhspshc...sh.P.ssp............tpps.pTPssshspst..........................p....s.pcslspsp..ss.s.............pp.shth.thph.sstlsssspphh.sptt..................................ssc.lcs.sss.hs.shspssphhtsh.t...h..s.s.h.......ts.sPs.................slhsspp.pu............ShtuppLpGssh+tpst..pspshp.phosppptpYpRl+pohGhTsAcpahppht	.......................st.s.sPpPsPsPp....PtPsPpPsP....pRFht.Y.GsPpshIpsRpNo-tIsltplts.sMhhhEDEshshpplsutahsNNphpA.shhlaPVscGpa.SV.IpCEGaQuspphusspcGph.GhIAYsssp..csWslGsYsGssIoNhhsssoa+.GH.D...hclNuspFsptQlVERDhshSFHlcss.ppupFhLhAPslpKos+YNasVSYGsaT-+hMEaG.ISVslDEp..tu.p.....sphscps.h+ss+h..hsps.p.......s...p...............................................t.ts.ppP.t.........................................................................ph..............................p.s.h............tst.....l......ts....h.tt........................................ssp.hc....t.hs...s.p...hss.............s...h..........s.ssp...........................ph..ttt....t.........................................................s..st.lpusp..tt....p.phh..phoppphtpYpplpps.s.ssAptah.t..t.......................................	0	0	0	0
+727	PF03126	Plus-3		Plus-3 domain	Bateman A	anon	Bateman A	Domain	This domain is about 90 residues in length and is often found associated with the Pfam:PF02213 domain.  The function of this domain is uncertain. It is possible that this domain is involved in DNA binding as it has three conserved positively charged residues, hence this domain has been named the plus-3 domain. It is found in yeast Rtf1 which may be a transcription elongation factor [1].	21.20	21.20	21.20	21.60	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.23	0.72	-4.00	39	464	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	274	4	319	438	6	106.20	28	16.55	CHANGED	c-lpplplsRohltchhhpP.tF-pslhGCFlRlslGsscpptt.....YRlspIpulppst...sYph.......tphtTshhlplppup..pp+.aphshlSspshscpEapcah.pphtps	.....................plpclpLsRspltchhthP..hFc.csltGCFVR.lslGs..pppp............YRlspItslscss...sYpl...................sshpTsphLpl......ppGp......sp+.aphphlSs.ptFo-sEapcahpsh...h...................................	0	102	178	263
+728	PF04043	PMEI		Plant invertase/pectin methylesterase inhibitor	Yeats C	anon	Yeats C, McQueen A	Domain	This domain inhibits pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex [1]. It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension (see [2]). It may also be involved in inhibiting microbial pathogen PMEs. It has been observed that it is often expressed as a large inactive preprotein [1]. It is also found at the N-termini of PMEs predicted from DNA sequences (personal obs:C Yeats), suggesting that both PMEs and their inhibitor are expressed as a single polyprotein and subsequently processed. It has two disulphide bridges and is mainly alpha-helical [2].	26.70	26.70	26.70	26.70	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.24	0.71	-4.31	142	1441	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	79	25	905	1470	0	147.00	18	43.47	CHANGED	sss....tp.hlp...shCpp..Ts.......st.hChpsLss.......tttsss.p...s....lhphsl.phshspsppshshl.p....plhtp....................spstpt..ps......slp....sChchhssul.c.pLp.puhpsl.............................pt...sc..........spsh.lSuAh....sstpoCt..-uh.................pts..h.......p.h...pt......pslpcl.......sssuLul	..............................................................s....t.lpthCpt.....o...............st.hChpsLts............tstsss.p....p............lhphul..phshs..psppshshh.p......plhpt....................sts.pt....ps....ulp.......sC..h.c.h.hst...ul..s.pLp...puhp.sl.................................pt...ss..........spsh.lS.u..A.l....sstpTCh.....-ua...................tpsthp.....s.lt.....tt......pphtphsssuLuh....................................................................	0	137	531	706
+729	PF04721	DUF750	PNGase; 	Domain of unknown function (DUF750) 	Waterfield DI, Finn RD, Pollington J	anon	Pfam-B_4045 (release 7.5)	Family	This family of proteins with unknown function shows similarity to PNG-1, a enzyme responsible for de-N-glycosylation of misfolded glycoproteins in the cytosol [1]. However, unlike PNG-1, this protein does not contain a catalytic triad in its transglutaminase domain [1].	21.30	21.30	21.30	22.10	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.14	0.72	-3.98	23	98	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	42	4	71	108	0	62.70	37	13.79	CHANGED	pNYlKFTYDllssoYS+sscDGSslp.PahlpNlcRl.-........pp.stsYlcp.pstc.u.........................ItWpFs	......h.......YsllcDpY.....s+sss.....s.....spslp.....sac.....hcsIhRKVE........pDWphVYLsR.cEuss.uh........................ISWKF-......................	0	42	46	55
+730	PF03726	PNPase		Polyribonucleotide nucleotidyltransferase, RNA binding domain	Griffiths-Jones SR	anon	Bateman A	Domain	This family contains the RNA binding domain of Polyribonucleotide nucleotidyltransferase (PNPase) PNPase is involved in mRNA degradation in a 3'-5' direction.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.72	0.72	-3.71	21	4259	2009-01-15 18:05:59	2003-04-07 12:59:11	9	35	4196	34	982	3077	2312	81.70	30	11.36	CHANGED	sLhpcltslApsclupAapI..ssKp-RhsplDpIKspVhtthh...tppt......phsppclpslapsLcpclVRppIlsspsRIDGRc	............................................L.splpshs.p.s.c.l..pc.Ah..pl.......p-KppRpstlc.tlK....pclhs....phh.............t...p..p..p..................................................ph..s..t..p.-...ls...p...h.hc...plc+clVRptIlssch......RlDGRc.....	0	334	637	830
+731	PF01357	Pollen_allerg_1	Pollen_allergen; 	Pollen allergen	Bateman A	anon	SCOP	Domain	This family contains allergens lol PI, PII and PIII from Lolium perenne.	20.70	20.70	20.90	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.82	0.72	-4.18	136	1558	2009-01-15 18:05:59	2003-04-07 12:59:11	16	11	171	13	632	1490	0	77.50	40	32.72	CHANGED	lpFplsut...saa.hVLlpsluGsG-lssVplK.......................G............o....s....WhsMs+sWGssWp..hss...th.hst.sLSFRl..Tot-..Gpslsu.psVlP	..................l+FslsGt....s.aa.hVLlpNVuG.sGDltuVslKt..............................................st............o......s.Wh.s.Ms.R..N...........W...G.....t..s..........Wpssu...hh...st.....sLSF+l..Ts.s-...G..+..slsu...sVhP..............................	0	78	341	494
+732	PF01522	Polysacc_deac_1	Polysac_deacet;Polysacc_deacet; 	Polysaccharide deacetylase	Bashton M, Bateman A	anon	Pfam-B_502 (release 4.0)	Family	This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB (nodulation protein B from  Rhizobium) which is a chitooligosaccharide deacetylase [1]. It also includes chitin deacetylase from yeast [2], and endoxylanases which hydrolyses glucosidic bonds in xylan [3].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.34	0.71	-4.49	104	13288	2012-10-03 16:37:10	2003-04-07 12:59:11	16	176	4258	46	3692	10795	3031	133.50	20	38.42	CHANGED	ttsssp+slhLTFDDGs................................sshssplLslLpchplpATa.FllGp.h...sppt...............................................................................sphl+chhppG.aplusHo...................hsHs.......ph..........sshssp.phpp-lppspphlpph..sGp.psph..hRsPaGt......hssss....hphspphGhphs	..........................................................................................................t....tp.lhlT..F.D.D.G.................................ts.h.s..s...p.l.l.s.....l.......L.......c.......c.......h.........s........h......p.......A..T..a..Fl..hup..h..........hppt.............................................................................................................s.p...h.l...+..c.h.h..p......p..G...ac......l..u.s...Ho.........................................................................a..s..H.................ph............................................................sp.h.stp..ph....p.p....-.l...t....c...s....p......p....h...lp...ph................h...G...p....p.....s.ph................hp.......h...P..h..Gt..........hs.p..p..s.......h.p.hh.tt.th...h..........................................................................................................................	0	1356	2490	3163
+733	PF04831	Popeye		Popeye protein conserved region	Mifsud W	anon	Pfam-B_3905 (release 7.6)	Family	The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains [1].	28.10	28.10	28.10	28.70	26.40	27.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.83	0.71	-4.47	10	249	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	76	0	142	229	2	145.50	45	44.99	CHANGED	EhcuLYpslapPLpVPlclF+cIstshtscVpoLpp-psYAlEGKTPI.DRLSlLLSGRl+VSh-GpFLHYIaPaQFLDSPEW-SLRPSEEGtFQVTLTA-s-C+YloWpR+RLYLLLsp-RYIuRLFSlLLGpDIu-KLYuLND..KlauKpGhRh	..............................Ehp.lYpslFpPLpVshphF+clstsh.pplhoLcptpsYAhEscTsl.D.+LSlLLSG..........+.........l+VS.c.GpFLHhI.aPhQFlDSPEWcShp......o..c-.shFQVTlsA-ssC+alsWpRc+LphhLtp-taltclFshLlGpDIscKLYuLN-..phhsphth..h...................	0	36	47	88
+734	PF01558	POR		Pyruvate ferredoxin/flavodoxin oxidoreductase	Bashton M, Bateman A	anon	Pfam-B_350 (release 4.0)	Family	This family includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein.  It is not known whether the  gamma subunit has a catalytic or regulatory role. Pyruvate oxidoreductase (POR) catalyses the final step in the fermentation of carbohydrates in anaerobic microorganisms [1]. This involves the oxidative decarboxylation of pyruvate with the participation of thiamine followed by the transfer of an acetyl moiety to coenzyme A for the synthesis of acetyl-CoA [1]. The family also includes  pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited [2]. 	20.70	20.70	20.90	21.30	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.99	0.71	-4.36	119	5899	2009-01-15 18:05:59	2003-04-07 12:59:11	13	69	3035	27	1854	4841	1225	177.10	23	24.80	CHANGED	G..GpGlhosuplLupus.hppG...ht.lhshppausphR......GGss.hsplR.lus.c..h......sth..t.psDhlluh................ct.psh..t..phhst..lpss......Ghllh..ssshhsst.ht.th.........................................slsh...pclAt.........chhs.......shhhNhlhlGsh.....sthhs..lsh..-s.....lppslcpphs.tt......................thlctNhcAhctGhp	..............................GGpGslsuuchhsphh..tp.ps...................hh...spsh.sas..ucp+......G.G.so.huclR..huc..p.hh...................sshhh.s..psDhllsh..................s..thl.p.......phhpt...l+pG........Ghhll....No....hh...ss...p..th.tpth..................................................................phhhlsu.splAp.............................-h.sh...............stthNhlhhuuh........h..plss...lsh..........-s...........hhctlcpp.....hs.pp.......................pll-hNhp.AlctGh............................................................	0	715	1316	1619
+735	PF01855	POR_N		Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	Bateman A, Griffiths-Jones SR	anon	Pfam-B_323 (release 4.2)	Family	This family includes the N terminal structural domain of the pyruvate ferredoxin oxidoreductase. This domain binds thiamine diphosphate, and along with domains II and IV, is involved in inter subunit contacts [3]. The family also includes pyruvate flavodoxin oxidoreductase as encoded by the nifJ gene in cyanobacterium which is required for growth on molecular nitrogen when iron is limited [2].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.34	0.70	-4.85	32	5386	2012-10-02 16:07:47	2003-04-07 12:59:11	14	71	2734	21	1633	4863	884	224.70	28	29.55	CHANGED	puuhtss.cshuuYPITPuos..hsEthsphhspuph..........phlphEuEhuAhuslhGAuhuGu+shTuTSu.GlhLMhEslhhhuupchPhVlhlssRuhsusulslhs-psDhhtsR......-sshhhLsssslQEuaDhslhAatlA.c..splPshhhhDGahsoHphpplpl.s.-.....hhcp.h.shcchp.........hhsP.cpPlstsstts.sshhptcctst.shptstthhpphhc	...........................................h.suhtss.c.h.h.uhYPITPSSp............hsEhhs..p.h....t.spstt.......................phlp..h.p.s..E.h.uAhuss..h.G.As..h...u.G.uh..s..h.T.s.Tu.u.GL...L.Mh-..s.l.h.h..h...u...s.p..tl..P..h.Vlhs..ssRus.....supuL.sh.hs-...p.uDl.h.ts.p.......ps.s.h.s.hLss..uos.QEsh.Dhsh.hAaphu.c.......hpsPhlhhhD.......G.....h..h..s.......H...t....h....p....p.....l...p..h.......c..c..........h...........t.....h....h.....t.p.........h....h.t.t....p...p.......................thss...pt...s.........h..h.s.s...............s.h.h.h.p..tptth......p..........................................................................................................	0	680	1192	1447
+736	PF04151	PPC		Bacterial pre-peptidase C-terminal domain	Yeats C	anon	Yeats C	Domain	This domain is normally found at the C-terminus of secreted bacterial peptidases. They are  not present in the active peptidase. It is  possible that they fulfill a similar role to the PKD (Pfam:PF00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C).	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.72	0.72	-3.01	151	2040	2012-10-03 16:25:20	2003-04-07 12:59:11	10	196	870	21	476	1650	202	70.40	24	12.12	CHANGED	spchaphsls..suss.ls..ls...l.......suss............................ss-..Lh..lhtss......s.....shss......hssts..............tss.....................ssppss..hss.....spsGs.Y.altltu	.......................................t..phashpls....sups..ls...ls.....l............ssts............................ssD.........la...lhtss.........s....................shss.......hssps.........hpsu.................................ssppss...hss.....stsG.p..Y.altV..h..........................................	0	158	302	417
+737	PF01577	Peptidase_S30	Poty_P1; 	Potyvirus P1 protease	Bashton M, Bateman A	anon	Pfam-B_364 (release 4.1)	Family	The potyviridae family positive stand RNA viruses with genome  encoding a polyprotein. members include zucchini yellow mosaic virus, and turnip mosaic viruses which cause considerable losses of crops  worldwide. This family consists of a C terminus region from various plant potyvirus P1 proteins (found at the N terminus of the polyprotein). The C terminus of P1 is a serine-type protease responsible for  autocatalytic cleavage between P1 and the helper component protease  Pfam:PF00851 [1,2]. The entire P1 protein may be involved in virus-host interactions [1].	19.70	19.70	20.00	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.39	0.70	-4.98	26	1446	2012-10-02 13:45:52	2003-04-07 12:59:11	11	18	127	0	1	1522	0	212.30	29	12.60	CHANGED	tpppsphttchhppp.....huphchpcpuphhh+thstptltcpppptpppccpppp.....hphthsshssshshttttthscstssphppt.hhppospch+pptspcphttssp.lstlhcplhpIspccshsVElIuK++..tspspa++hpushhhplpltHhpGphp+hDlshsphtpplhthhutpttppppspshph..GsSGllhpspphhs.hthsptshFlVRG+psGp....Ll-ARs+lspt.hpplcH	..............................................................................t...t.p.pthhhc.c...........uhhh.tpp.p.tslhhp...h.tspp...l.+.ppcthcp+ctcEtp.......h.h.thp.s..h.stho.h.s.ss..sss.t..hp....s.ph.ppt.......hppo....ph.......+c.p...h.s.h..p.p.s.+.....h.spt..hp....hlh+plhpIhp..tp.s.ts.lEh.Iu++p....hclpahc.h.t..t.s.phstlpssHh...G.h.....+.....tp.....h...D..h.....hs......p.t...hhlphhuth..st.p....p..hpshslp.G.SGlllpst.l...ht...hs..+s........p.p.........hFllRGc..c.c.G+....LhDARt+lop...pcl.p......................	0	0	0	1
+738	PF03291	Pox_MCEL		mRNA capping enzyme	Mifsud W	anon	Pfam-B_4078 (release 6.5) & Pfam-B_3482 (Release 7.5)	Family	This family of enzymes are related to Pfam:PF03919.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.17	0.70	-5.57	11	647	2012-10-10 17:06:42	2003-04-07 12:59:11	11	21	389	17	358	751	441	284.20	25	61.34	CHANGED	ch..ppspshsshVssH...........Ysch............pcss..hchRppSsIhp.............................................................................................................................................................................L+pFNNaIKolLIuhasp+s..c....sshpVL-lsCGKGGDL.KathutIuthlusDIucsSlppspcRY...pphppt.cpchh+hsa.schlsuDsahsplpEhahss......hpF..DllShQFAhHYSFcoccpAchhLpNlschLssGGhhIuThPDushl......++Lpt..t.stpcphGNslYploF-cp..........s.aGphYsapLcsslpssPEYlV.FssLhclsccYshpLl.phsFp-hhcp.h.p.cp+hhlpphsul-spsupp........................p...tshpusEhEAsh.hYllasFcKp	.................................................................................................................................................................................................................................................................................................................................................................................................................................................t............l.ta...........Ysth....................t...........+.tts.l............................................................................................................................................................................ht.hsN.a...l.KohLIp....a..................h..........p.............................................................................tt..............tV.LDlsCG..+G...u...DL.K.a.....h.....u..t...............l..th...............hl.shD...........ut.ul....p.p....spp....RY.................................t............................p.........p.............................a.......t....p...h.h.ht..D..............sh............p.....ltph..h..............................F.....cllsh.............F.shHYuFcspppu..........p.hhpNhs.thLp.GGhhluo..hssu.p.l...................................tpl....pt....................................t.........t.......ph...s......s....ph....h.tl..p..att..................................................hG.h.....ha...a....h........p.p...h.s......................t...........hsEalV.h..h..h.t.lhpcashp..Lh.....p.......sF.p.hhp.............................ht......................................................................................................................................................................................	1	117	205	299
+739	PF00481	PP2C		Protein phosphatase 2C	Bateman A, Finn RD	anon	Prosite	Family	Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.72	0.70	-4.99	31	7190	2012-10-03 01:39:20	2003-04-07 12:59:11	16	293	1352	43	4244	8910	707	218.80	20	49.91	CHANGED	hshshsphpuh+pphpDsphthtsh.t.......ssp.shshhslaDGpuGppsuchsspplt.....phlppppsh.ps.................thppsltpuahp..tc.thtp.....t..........s.puGsoAssshlpspc........LalANlGDS+slLspssssh...........tLopcHcPssts.EppRIppsGGhlp......sRlsGs.....................LulSRAlGDhphKs..............................hVsupP-ls..ptplsts.D-FllLAsDGlWDhlsspcsl-ll+pphst............spcsupcLhchuhshuop-sh	..................................................................................................................................................................................h.........................................................................h....hs.l.h.DG.....h.....s......G...........t.......s.....up.....h.ht....p...h..................t..h....t............t...........tt.................................................htp.h..l...t...p..s...hht........h.s.tthhp.........................................................t..tt.s.G..o..T..s.......s...s...s..l..l.....s.pp...................................lhl...AN..s.GD.........S...R..s......l........L...s.....p....p..st.h..............................................L.o..t.DH.p................s.....t.........p......................t......E.t....t....R...l..p..t.....t..t...u......h.....................+..lt....u..................................................................................................l.sh....o...R......u......h.........G...D.h.....hc.................................................................................................hl.st.P-.lt...............hp.l..........p...........p.....c..............p........a.......lll......us...............DG..l......a.....c..............h........h.......s.s....p......p........h.s..p.h.l..t..p......t...............................................hs.p.lht.s............................................................................................................	0	1476	2539	3487
+740	PF00823	PPE		PPE family	Bateman A	anon	Pfam-B_297 (release 3.0)	Family	This family named after a PPE motif near to the amino terminus of the domain.  The PPE family of proteins all contain an amino-terminal region of about 180 amino acids.  The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups.  The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.65	0.71	-4.40	146	3533	2012-10-01 21:44:22	2003-04-07 12:59:11	14	54	122	2	395	2191	1	151.60	45	28.01	CHANGED	slP..PElNSuhhauGPGuushlAAAuAWsuLAuELssuAsshsullusLs...sss.WpGPuusuMsAA.ssPYluWLsssAupAppsAuQAcuAAuAYEsAhAuhVsPshlAANRsthss..LlATNhFGtNosu.......IAssEA.pY.scMWuQDAsAMhuYtusuuuAss	...................................hlPPElNSuhha.uGsGsuPhlAA..AuAWcuLAsELssu.Asuas.u.llusLs..........sts.W.pG.PuusuMsAA.ssP........Ylu.WLsssAupAp.tuAsQAcAuAu..AaEsAhAusVs.P.s....h.lA.AN...R.sthhs...L..lu..o.N....h....h..GQNosA.........IAs.sEA...pY...tcMWAQ....DssAMhuYtuuuuuAs.t..................................................	0	97	190	347
+741	PF01535	PPR	DUF17; 	PPR repeat	Bateman A, Birney E	anon	Pfam-B_874 (release 4.0)	Family	This repeat has no known function. It is about 35 amino acids long and found in up to 18 copies in some proteins.  This family appears to be greatly expanded in plants. This repeat occurs in PET309 Swiss:P32522 that may be involved in RNA stabilisation [1]. This domain occurs in crp1 that is involved in RNA processing [2].  This repeat is associated with a predicted plant protein Swiss:O49549 that has a domain organisation similar to the human BRCA1 protein. The repeat has been called PPR [3].	25.00	9.30	25.00	9.30	24.90	9.20	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.38	0.73	-7.57	0.73	-3.61	518	31410	2012-10-11 20:00:58	2003-04-07 12:59:11	15	3797	468	0	23088	82367	965	29.30	21	15.97	CHANGED	hoassllsuascpGphccAhplhpcMpppGh	....................asslls.s..a..u......+......s....G....p.....h.......c.....c.....A..h...p..lacpM.t.......................	0	2628	15898	19987
+742	PF04193	PQ-loop		PQ loop repeat 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Repeat	Members of this family are all membrane bound proteins possessing a pair of repeats each spanning two transmembrane helices connected by a loop [1]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [2]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought likely to possess a more general function. Most probably this involves a glutamine residue [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.69	0.72	-4.42	255	3702	2012-10-03 12:15:12	2003-04-07 12:59:11	9	33	711	0	2429	3643	533	59.40	21	35.09	CHANGED	huphlGhlshshhhlshlPQlhpNa+p+Ss.pGlShhhhhhhhhGshhthhhhlhpthsh.h	.........................h...hhGhhshhhh.h..h...s.hlP.Q...lhpsa..+.......p..+Ss.pGlShhhhhh..hhGsh..hhhhhhhhtt.....h..................	1	810	1368	2026
+743	PF05033	Pre-SET		Pre-SET motif	Bateman A	anon	Bateman A	Motif	This protein motif is a zinc binding motif [1].  It  contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.	21.80	21.80	21.80	21.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.44	0.72	-11.70	0.72	-3.75	86	1039	2009-01-15 18:05:59	2003-04-07 12:59:11	11	69	226	37	626	1020	2	109.60	28	14.91	CHANGED	chsput-s....hslslh........NplD............t-ts..P..tsFpYlsphhhsp...............................h....hstphhh.............GC.sC..p.......................ss....C...sspsC.Chpts.....st...h.................s.Y...sp.ptpLt................p...........................................sssIYECsspCpCs..t.sCtNR	.........................................................hs.uhEphslshh.........Np....lD......................sp.s........ssFp..Ylsp..hhsp................................sh.....hs.phh.........................uC..sC....p........................ss......C.......ssspC.Csphs..........tt...th.........................................s.Y..sp...pspLh.........................hpt...................................................sshIaECsptCpCs.......sCtNR.............................................	0	144	274	462
+744	PF00156	Pribosyltran		Phosphoribosyl transferase domain	Bateman A, Sonnhammer ELL, Finn RD	anon	Bateman A	Domain	This family includes a range of diverse phosphoribosyl transferase enzymes.  This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7, Swiss:P07672. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase Swiss:P51900. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8 Swiss:P36766. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1 Swiss:P09329. Amidophosphoribosyltransferase EC:2.4.2.14 Swiss:P00496. Orotate phosphoribosyl-transferase EC:2.4.2.10 Swiss:P11172. Uracil phosphoribosyl-transferase EC:2.4.2.9 Swiss:P25532. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22 Swiss:P00501.  In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain [1].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.41	0.71	-4.40	71	30853	2012-10-10 14:25:38	2003-04-07 12:59:11	22	68	5141	299	7483	25977	11727	121.40	18	48.82	CHANGED	pslh...hs.ctlpphsct......lupp....lpppths.........llultpuGlshustluptLsh...shhhhhh.h...........................................tthtppsspththhhthst.hcucclllV.DDllsoGtTlptshc.hLc.pts.sp........lthsslh	..............................................................................................................................................................t........t..htthhpt......lupt..............h..h..p..p........h....p....h...............llu.......l...............p.......t.......G.....h.............hu..t.......t...l...u...pt.l.sh...........s.h..h...h..s..h.h.ttp............................................................................................................................ttt..t.ppp.s.....s..t....t..h...h...h...t...h.......p....s.........h....p...G.......c.....c.....V.ll.V..DDl.lsoG.sT.hp.t.h.hc...hlc...ptG...up......hl.tlssh.h........................................	0	2412	4803	6327
+745	PF00377	Prion	prion; 	Prion/Doppel alpha-helical domain	Bateman A, Finn RD	anon	Prosite	Domain	The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.	25.00	25.00	36.90	36.70	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.62	0.71	-4.38	7	730	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	240	88	41	750	0	107.50	71	50.15	CHANGED	hp+hshcFGs-.tsRYYptN.hpaPstlaYcshsphsVspptFVpsClNhT.stpphp............u..cs.schc.+Vhh+llcEhCstpapcahLt....Ruuulplhss.PhhLhlLshlhFlht	.......MSRPLIHFGNDYEDRYYRENMYRYPNQ.VY...YRPV.D.QYS.NQNNFVHDCVNITVKQHTVTT..........TTKGEN...FTETDlKhMERVVEQMCITQYp+EupAa...pRGu.ShlL.FSuPPVlLL.lshlhhll.s.....	0	2	2	9
+746	PF00227	Proteasome	proteasome; 	Proteasome subunit	Finn RD, Bateman A, Valas RE	anon	Prosite	Domain	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.99	0.71	-5.02	174	10806	2012-10-03 21:14:07	2003-04-07 12:59:11	21	55	3712	1970	5186	9052	2184	173.50	21	77.89	CHANGED	hppGs.TslGlc.sccuVllu...u.-p.+so..ts.hlhsppp..h..cKlhpl..scclhhshuGhsuDsphlhchhct.psp.hac.hp.hs.c.hslp........hushhpthh.t..pt...th.psh...s.s.shlluGhD.p.p.s...t.spLaph..-ssGshhph....hsuhG.suuphuhs.hl-ppa....pts..hoh--u...hclshcult.t..uh..c..pst...hss..ssl..plshl	........................................................................................................pus.Thlu......lp.....t.......p.......s.......t.....lllu.............u..Dp.p.....s.......o.......t..s...hl..........t........p.s..p....h..........cK..l..h..pl....s..............s........p........l....h..........h.u....h..............u............G...........hs.A...D..s...t..sl...............h....c.hh........c..........t........p.......h........p.............a........p........h...........................t......t.....h...s..lp.....................................h.........s.........t...h...h....t.....s.........h.....t..........pp...............ht.....p......s.h..................h.l....phlh...u...Gh....s...........t....s..........................t...s...p.la.h..l.sss..Gshh......p............p............h.......h......A........hG..uGu...phAhu.hh.......c......phh...................t...s........h.........s.......p..c..A..........hc..ls.h.culp.....uh....c....hs.h......hos..p.phpl........................................................................	0	1761	2940	4236
+747	PF03371	PRP38		PRP38 family	Bateman A, Winge P	anon	Winge P	Family	Members of this family are related to the pre mRNA splicing  factor PRP38 from yeast [1].  Therefore all the members of this family could be involved in splicing.  This conserved region could be involved in RNA binding. The putative domain is about 180 amino acids in length. PRP38 is a unique component of the U4/U6.U5 tri-small nuclear ribonucleoprotein (snRNP) particle and is necessary for an essential step late in spliceosome maturation [2]. 	22.40	22.40	22.80	23.00	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.81	0.71	-4.65	41	560	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	309	0	382	526	4	168.00	32	51.79	CHANGED	tsts..tlpspssshllppllRp+IhsShYaKpphaslss..........pollDchhp.lcalGuhhsust+...................PosFlCLLhKLLplpPsc-Ilhphlppp..................................-aKYlRALuhhYlRLshss...................t-laphhE....PhhpDaRKl+hpstsu...........plhahD-alDpLLsc-chhslhLPRl.tR..hhL-ppstL	..........................................tt......lhGsssphllppll+spIhsS.YaK.phatLss.........cpllDchhp...lcalushh.s.G.sp+...................................PoshhCLlhKhh.plp.s+c.lht.hlppp...............................................-.p..YlRALGhh....Yl.....Rhstss........................h-lapahE....Phhp...D.cclchpstsG..............................plhphschlcpLL.......pcpchhs..hhLPRl.hp..h.hp..t..h................................................	0	142	214	311
+748	PF01789	PsbP		PsbP	Bashton M, Bateman A	anon	Pfam-B_1303 (release 4.2)	Family	This family consists of the 23 kDa subunit of oxygen evolving system of  photosystem II or PsbP from various plants (where it is encoded by the  nuclear genome) and Cyanobacteria. The 23 KDa PsbP protein is required for PSII to be fully operational in  vivo, it increases the affinity of the water oxidation site for Cl- and  provides the conditions required for high affinity binding of Ca2+ [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.09	0.71	-4.82	30	539	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	153	5	301	551	149	160.70	22	65.89	CHANGED	hssshsshhshshsustutssuGhpsa.sssDGYpFLYPsGW...pcVpl....sGs-llF+Dll-ssEslSVslossscc...olc-LGoPpc........VGcpLhcphluspGus.....RpAcLlcAspRcss.G+sYYslEatl+hss.....t............sRHpLuolsVscG+LYTlssuosEcRW.K.scchhcpllsSFslh	..................................................................................................hs................................h...h....t....t.....aph..hPt.t.W.............................phth........G....................hh..acs..............t.....t.p.s......ls.V..hlss....s........spp...........sl.p..ch.Gs..scp...........lu...ppl...h..t..t.hhs.s.tt.....................tpupllps..pp......pp...h....s..G.....c.tY..Yp.hEhtsp.tss........t......................t+Htlssss..l....s..s.G.....+.......LYhhss...p...s...s.-...p...p...W...t....c...hcphlcpshsSFpl.........................................................	1	93	210	266
+749	PF01416	PseudoU_synth_1	PseudoU_synt;	tRNA pseudouridine synthase	Howe K, Griffiths-Jones SR	anon	swissprot	Domain	Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in  all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.52	0.72	-3.60	118	11373	2009-01-15 18:05:59	2003-04-07 12:59:11	15	22	4733	26	3331	8399	4001	104.70	20	69.27	CHANGED	hthtahGp.sFpuap.........pp....................pshp........pshh+sltphph................................t.t.........................thhht.h+hhh.......sshhcs.spGhpuhsplt....ph.............................................Lspph.s...........tssshs.hhhcspas	......................................................................................hta.Gp..cFpuap.....................................pp....................................................pohp.........psh...+slpch.ph................................................................................................................................................................h+.h..hl........................sshscs....st...Gs.c.uhsp.ls..ch............................................................................................................................Lssp...s...s..........ss..sss..hhcsca.................................................................................................................................	0	1157	2111	2810
+750	PF01437	PSI	Plexin_repeat;	Plexin repeat	Bateman A	anon	Bateman A	Family	A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin (Swiss:P70206) [1]. Two copies of the repeat are found in mahogany protein.  A related C. elegans protein (Swiss:Q19981) contains four copies of the repeat.  The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas [1] shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.03	0.72	-3.81	95	2947	2009-01-15 18:05:59	2003-04-07 12:59:11	20	228	154	27	1472	2447	7	54.60	25	6.46	CHANGED	sCsp......a..poC.s.sClsup.t..tCuWCst.....tppC....spts.........................pCtptp....................t.tpp..Cs	............pCst......a..poC.ssC.....l.....tup.....cs..hCuW...Cst........ttpC....spts..................................................pC.t.t..............................................................................................	0	251	365	805
+751	PF04046	PSP		PSP	Wood V, Finn RD	anon	Pfam-B_PSP (release 7.3);	Family	Proline rich domain found in numerous spliceosome associated proteins.	18.30	18.30	18.80	19.00	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.35	0.72	-4.57	40	488	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	300	0	335	464	3	49.30	49	8.24	CHANGED	+PGhlSpcLRcALGhssss.....PPPWLhpMpch....GhPPuY..PsL+IPGlshsl	.....+PGpLS..-EL+pALGhs.sss............PPPWLhpMQ+h...................G.PPSY..PsL+IPGLNss...........	5	114	181	270
+752	PF04468	PSP1		PSP1 C-terminal conserved region	Waterfield DI, Finn RD	anon	COG1774	Family	This region is present in both eukaryotes and eubacteria. The yeast PSP1 protein is involved in  suppressing mutations in the DNA polymerase alpha subunit in yeast [1].	21.10	21.10	22.60	21.90	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.78	0.72	-4.00	138	1828	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	1651	0	508	1317	149	88.50	40	24.33	CHANGED	slppllRhA...o..pcDhpphppscpcp.ccAhphCpp+lpccs.............................L..sMKllcsEa....pFDpsKlhFYao......A-sRVDFRcLVK-LAphF+sRIEhRQI	............................................................................lKpllRhA...sppDlpphp.cscpct.ccAhplCpcplpcps........................................................................................................................L.......cM+LlcsEY..................shD.....p......sKll.FYFT.............A.-.sR...lDFRcLVK-LAphF.+.T.RIELRQI.....................	0	218	376	469
+753	PF04024	PspC		PspC domain	Bateman A	anon	COG1983	Domain	This family includes Phage shock protein C (PspC) that is thought to be a transcriptional regulator. The presumed domain is 60 amino acid residues in length.	21.80	21.80	21.90	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-8.93	0.72	-4.50	182	3398	2009-01-15 18:05:59	2003-04-07 12:59:11	7	17	2305	0	732	2173	337	60.70	32	37.58	CHANGED	pp+LhRsp....ps+hluGVCuGlAcYhslD...ssllRllhll...h.hl...........................h..sss...sl..l.........hYllhh..lllP..ppss	.....................p+LhR.s..psphluGVCuGlAcaas.l.-...ss.lVRllhllhsh............................hsss.....ull.........hYl.llh..hllPtt..s..............................	0	264	511	639
+754	PF04886	PT		PT repeat	Bateman A	anon	Pfam-B_517 (release 7.6)	Repeat	This short repeat is composed on the tetrapeptide XPTX. This repeat is found in a variety of proteins, however it is not clear if these repeats are homologous to each other. The alignment represents nine copies of this repeat.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.01	0.72	-4.63	15	489	2009-01-15 18:05:59	2003-04-07 12:59:11	7	108	180	0	258	482	734	37.20	41	7.69	CHANGED	pPTspPospPTspPTupPospPTspPTspPostPos	.............................PotpPTspPTsp.PT..spPTs.pPT.spPTspP.ottP.....................................	0	131	163	221
+755	PF01329	Pterin_4a		Pterin 4 alpha carbinolamine dehydratase	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	Pterin 4 alpha carbinolamine dehydratase is also known as DCoH (dimerisation cofactor of hepatocyte nuclear factor 1-alpha).	20.80	20.80	21.20	21.00	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.29	0.72	-4.23	136	2229	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	1838	50	880	1778	2287	90.20	32	78.95	CHANGED	s.s..s.hLoppchpph..Lp.pl..s.....sW..plt...s...........tplp+p.apFcsFtpAh...uFhspVuhlAEptsHHP-lts.sascVplphhTHcl....s..G.LocpDhhhAs+h-plhp	....................................................ht....lsttphtth..Lt..tl.....s..........sW...p..h.......s..............stlp+.p.a..pFp.s.......Fp.pAh..................uFh.s.c.lAhh.AE.......ph.s.......HHP.-.hhs....s.........as..p.........V.plsl..h..TH..sh............s...G...locpDhthAtph-tlh.t...........................	0	282	549	745
+756	PF03095	PTPA		Phosphotyrosyl phosphate activator (PTPA) protein	Mifsud W	anon	Pfam-B_2456 (release 6.4)	Family	Phosphotyrosyl phosphatase activator (PTPA) proteins stimulate the phosphotyrosyl phosphatase (PTPase) activity of the dimeric form of protein phosphatase 2A (PP2A). PTPase activity in PP2A (in vitro) is relatively low when compared to the better recognised phosphoserine/ threonine protein phosphorylase activity. The specific biological role of PTPA is unknown, Basal expression of PTPA depends on the activity of a ubiquitous transcription factor, Yin Yang 1 (YY1). The tumour suppressor protein p53 can inhibit PTPA expression through an unknown mechanism that negatively controls YY1 [1].	20.10	20.10	21.30	20.50	20.00	19.70	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.06	0.70	-5.25	53	620	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	316	20	404	615	5	265.50	37	78.11	CHANGED	tPsKRIhss.pDlphFtpStsapclhsFlpslsculpGpphs..........pshthSs...........................................slppllp.lLcclppllccsPP....hct.s.sRF......G...NhuFRsaa-clp...........ppsssllpphlss.................ttpsslsELssYlhpS..FGsppRlDYGoGHELsF.lsaLhsLhclu................llp.pp.........D.............hssllLtlFscYlclhRcLphsYhLEPAGSHGVWGLDDapFLPFlaGuuQhhscsh.hp........................Ppulpsppll.........-.papcpahYhssIsFI.splKou........shp.HSPhL.DISust.sWsKlpp................GhlKMYpsEVLuKhPlhQHFhFGs.Lhshscshss	..................................................h.P.+cIhs..tDhthahpS.......satphhsFlhp.lscultspphs................t...st..................................................................................slpplht.lLsplpphl......cchPP.........pt..s.....pRF..................G...N.huaRpahpc.lp...........pps....plht..ph..l.st.........................................................................t.tts..h.ElssYhhpS..aGstpRlDYGoGHEhsF.hhaLhsLhpls............................hhp..tp-...........................................sllhtlF..pYlp..lhRpLphsY..hLEP.AGSH....GVWGLDDapFLPal.aG..uuQ..ht.p..h...hp...............................................Ppphhptphl..........p.p..t.pphha.hpslt..al......pp.hKpu............shttHSs.L.sISus...sWsKlpp................GhlKMYp.sE..VLtKhPlhQHFhFGs..Lhsh.....s........................................	0	157	237	341
+757	PF02302	PTS_IIB		PTS system, Lactose/Cellobiose specific IIB subunit	Mian N, Bateman A	anon	Pfam-B_9339 (release 5.2)	Domain	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes. The fold of IIB cellobiose shows similar structure to mammalian tyrosine phosphatases.  This family also contains the fructose specific IIB subunit.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-10.36	0.72	-3.50	245	18949	2009-01-15 18:05:59	2003-04-07 12:59:11	12	57	2638	16	1606	8004	181	89.10	20	29.08	CHANGED	pllssCssGhuoShhstpplcctscptG........l-s....pstsss...hptpphts.s.Dllllus...plp......phpphss............hhhlshps......hh..tsscpllpp	................llssCssGhuoShhstptlcctspchG................................l-s....psssss.......hp.tps.h..tp.s..Dll..l.hus.plp........phpphss........h.........h.hlshts....hh....phtthh....................................................	0	438	856	1245
+758	PF01472	PUA		PUA domain	Bateman A	anon	Medline:99193178	Family	The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes [1].  It is predicted that the PUA domain is an RNA binding domain.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.05	0.72	-4.25	108	4603	2012-10-02 17:37:24	2003-04-07 12:59:11	15	42	3369	67	1812	3731	1805	74.30	29	20.31	CHANGED	splhlDcuAscultp..Gu.sLhssGlhpscssh......ctG-hVhlhsp....p.G........chlAhGhuthsupEhtchp..tttusclcphl	....................GplhlDcGA.spAlhp.....Gs...SLLssGlh......p.....l......pGsF............................ptG-sVt..lh..st...................p.G..........................................ctlA.pG..lspasus.cl.p..p..ht...tth.utcltt.............................................................	0	564	1073	1503
+759	PF01480	PWI		PWI domain	Bateman A	anon	[1]	Family	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.59	0.72	-3.88	34	907	2009-01-15 18:05:59	2003-04-07 12:59:11	12	44	271	2	602	867	4	72.20	28	10.85	CHANGED	l-llKsWIsc+ls-lLGhEDDlVl-ashshLp......................tpc....DsKplplpLsGFLs.+suttFsp-LWcLLluApps..pG	........................-hlKsWls++lp-..l.lG.h.-...-......s..s.l...l-a.lhsh.lctt...............................s..c.p.h.h.p.pLss..F..Ls..ccs...pt..FlpcLWchll.tppt...t.............................	0	199	312	474
+760	PF00787	PX		PX domain	SMART	anon	Alignment kindly provided by SMART & iterated	Domain	PX domains bind to phosphoinositides.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.35	0.71	-4.28	71	7076	2009-01-15 18:05:59	2003-04-07 12:59:11	19	282	785	46	4186	6459	70	114.90	20	19.35	CHANGED	sthhp..hthss.t.......spttthhhhplphpss..............tphpltRRYp-FhpL+ppLpcphs.....................thhlP.hPsKthh......................................................hppphlccR+.ptLppaLpplhppPhhtp.....schltpFLpsp	........................................................................ht............................tththhh..h.h..plp.hpss..............................pht..V...hR.RY..p-..F..ttL....cp..p..Lp...cpas.........................................................th.h.lP......lP.t..Kp.h.h.st...........................................................................................................................................................hppp...h..l...c...c...R+...p.tL.p...paL....p..............p...l..h....p....p..s..h..ltp......sphht.pFLp..t....................................................................................................................................................................................................	1	1382	2076	3184
+761	PF02194	PXA		PXA domain	SMART	anon	Alignment kindly provided by SMART	Family	This domain is associated with PX domains Pfam:PF00787.	21.10	21.10	21.30	21.10	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.17	0.71	-4.72	69	830	2009-01-15 18:05:59	2003-04-07 12:59:11	10	30	257	0	547	794	2	167.90	23	19.45	CHANGED	sstlsptlppll..shll+-FVps.WY.ppIossp..pFss.plcpslppsltplppRlp...............phDhssllspclhsllspHlphappAppth.............................ht...spspthplhhshphpss.....csA.htsptpphp.........................................alRtlspslLshlLsppphpstslpsLl+ElLussVLhPllp.hlu-P-alN...phIlthhpss	............................................lsttlppllphllc-aV.s.WY....pp.........l.o.scp....pF.p.pl.cpslpthhtp.lpp.R....h.p...........................cl..D.h...sl..l.............sp.......cllshhspHlphhp.pAppth...........................................................................ttt...p...hp.h.ht.p.t.t............hc.u..h....psp....pppht....................................................................................................................aLRpl.sp.hll...hl.LP.......pt.............h..........p.......sp.......shphllpEllu....ssl.lhPh.ls.hlucP-hlN...phlhhhhp..s...............................................................................................................................................................................	0	173	277	432
+762	PF00070	Pyr_redox	pyr_redox; 	Pyridine nucleotide-disulphide oxidoreductase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.49	0.72	-3.57	130	40648	2012-10-10 17:06:42	2003-04-07 12:59:11	22	455	5442	395	10595	41559	13431	81.90	22	17.40	CHANGED	+llllGGGhIGlEhAshh....pp.hG...t..cV.ollcttsplh....hhstp.huphl..pcph.ccp....Glplhhssplpplp......tsss.t....lhhp......ss	..................plsVlGG.Gh.l....Gl....Eh.A.thh.............................pp..h..G.................s.......c..V..o.....l..l...c.t....t..s..........p...l.........h..............................h...........s.......................p......h...........s...........p.......h..........h............pc..p....h...p..pp...............G.l...pl..h..h..s..s....p.l..p..p.lp........tss.t..t.......l.....tttt.............................................................	0	3391	6626	8921
+763	PF02852	Pyr_redox_dim	pyr_redox_dim; 	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	Griffiths-Jones SR	anon	Structural domain	Domain	This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.34	0.72	-4.03	102	18533	2009-01-15 18:05:59	2003-04-07 12:59:11	17	94	4904	322	4408	13761	3778	109.20	27	23.24	CHANGED	lPsslaopPElAsVGl...TE.ppApppsht......lcltphsas..........sss+Ahshtp......scuhlKllsct.cspclLGsHhlG.spuuE..hIpthulAlchuh...Thp.-.hspsltsHPThuEthtpss	.....................................lPtshaopP.pl.AsVGl....T....E....pp....A....+....p....p..s.hp................hcstp..h..sas.......................s...s.+..A...h.shsp...............spGhh.Kl.l.......h......c.............t.....c......o.......pc..llGsph...l..G........s..u.sE....hIpt...hul...Al.....c..h.s.h...ohp...p..h..sp..sla.sHPThuEshh...h.........................................	0	1486	2777	3700
+764	PF01729	QRPTase_C	QRPTase; 	Quinolinate phosphoribosyl transferase, C-terminal domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2063 (release 4.1)	Domain	Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other.  The C-terminal domain has a 7 beta-stranded TIM barrel-like fold.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.98	0.71	-4.73	18	3824	2012-10-03 05:58:16	2003-04-07 12:59:11	14	9	3313	84	1170	3336	1907	167.10	40	57.32	CHANGED	IATtTpchlctscus..ps+lhsTRKTtPG.LRhh-KYAVhlGGGs.......sHRhGLsDslhIKDNHIsssGu...lpcAl+psRphs.shs....lEVEl-sL--hccAlp.........uG....ADlIMLDNh.........ss..-pl+cAlc.h.ctpshc....hhlEsSGGloh-sltpaApsGVDhIShGsLT+uspslDlSLc	..................................................................................lAThTpphVct.lpus................pspl.hDTRKT.h.P...G...L.R..h.h.p.K..YAVhsGG.Gh................NHRhGL.....sDul.......LlK-....N....HI....t....s........s......G..u........................l.pp....A...l.ppA...+t...ht....st...h...s.........lEV...E.V...-...o....L....-.....p.....l.c.....-..Alp.....................................AG...........AD..lIhLDNh........................ss......-ph.+.....c.A.....V.p.........h..h..ss+...........shlEs.SGsl..oh.cs..............lpp..h..A...p..o...G...V....DhISlGu...L.T...+...ss.pslDlShc........................	0	388	754	980
+765	PF02749	QRPTase_N		Quinolinate phosphoribosyl transferase, N-terminal domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2063 (release 4.1)	Domain	Quinolinate phosphoribosyl transferase (QPRTase) or nicotinate-nucleotide pyrophosphorylase EC:2.4.2.19 is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to give rise to nicotinic acid mononucleotide (NaMN), pyrophosphate and carbon dioxide [1,2]. The QA substrate is bound between the C-terminal domain of one subunit, and the N-terminal domain of the other.  The N-terminal domain has an alpha/beta hammerhead fold.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.54	0.72	-4.16	161	3866	2012-10-02 20:27:15	2003-04-07 12:59:11	11	8	3303	80	1158	2967	1621	88.60	32	30.01	CHANGED	hs...tG.DlTo..shlsssppup...uplhu+ps.ullu.Ghphspp.lachl....................sl.plp..hhhpDGcplpsGs........hlhplpGsucslLpuERsuLNhLp+hS	......................................sDlTs.....tll...s.s..s.p.p...up....upll..s.+..-.s.GV.l.u...Ghp.h.sp.p.lFptls........................................ssl.plp.......hthp...DG-tl...ps..sp..........................sl..hp..lpGss+sLLsuERsALNhlpphS............................................	0	387	749	973
+766	PF01424	R3H		R3H domain	Bateman A	anon	Medline:99003905	Domain	The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues.  The function of the domain is predicted to be binding ssDNA.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.15	0.72	-4.27	402	3275	2009-01-15 18:05:59	2003-04-07 12:59:11	17	89	2043	7	1332	2719	355	63.80	24	13.76	CHANGED	cppplpphspphhpps....h........pss...p.........shphp.P..h.ssh-R+.llH.phsp....th.....s...lpopS..t.......G.pt.sp..Rplllthp	...........................................................l.phspchhppl....h.....................css.........c..........shphp.P.....M..sshER+.l.........lH.phsp...hh.....s....lpopS.....p.........G...cc.sp...Rtl.ll......................	0	444	749	1050
+767	PF03834	Rad10		Binding domain of DNA repair protein Ercc1 (rad10/Swi10)	TIGRFAMs, Griffiths-Jones SR, Coggill PC	anon	TIGRFAMs	Family	Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain.  Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex [3].	22.10	22.10	23.90	23.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.48	0.72	-4.28	26	301	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	268	3	216	287	4	67.50	46	21.96	CHANGED	psILVsspQ+GNPlLpp..l+slsWca.s.-....IlsDYhlGpspslLFLSLKYH+L+PEYIapRlcpLpp.pash	...............sIlVu.sR.....Q+GN.PlLpa..l+.s..ls.WEa.u..D.....I.s.sDYll.....Gpo.oCsLFL.SL+YHpLH.P-YIapRlcpLsppat.h........	1	73	120	178
+768	PF04423	Rad50_zn_hook		Rad50 zinc hook motif	Bateman A	anon	Bateman A	Motif	The Mre11 complex (Mre11 Rad50 Nbs1) is central to chromosomal maintenance and functions in homologous recombination, telomere maintenance and sister chromatid association. The Rad50 coiled-coil region contains a dimer interface at the apex of the coiled coils in which pairs of conserved Cys-X-X-Cys motifs form interlocking hooks that bind one Zn ion. This alignment includes the zinc hook motif and a short stretch of coiled-coil on either side.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.55	0.72	-4.50	32	262	2009-01-15 18:05:59	2003-04-07 12:59:11	9	18	230	2	157	265	13	53.50	26	4.97	CHANGED	phcspttphpctlpplppspt..sCPlCtRslss-cc.pclhpchppclpph.cchp	.............htttht.hpphlppLsc..ppt..sCPlCpRshss-pc..pcllpchpsclcth.cp..................	0	38	69	121
+769	PF04055	Radical_SAM		Radical SAM superfamily	Bateman A	anon	Bateman A	Domain	Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.	29.40	29.40	29.40	29.40	29.30	29.30	hmmbuild  -o /dev/null --hand HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.13	0.71	-4.08	628	65493	2009-09-17 13:13:13	2003-04-07 12:59:11	16	316	5136	37	18526	49841	14153	169.40	14	43.97	CHANGED	h.hsssCshp.....CtaCthtt...............................................................htttttthshcplhchhcph...ph...hp.tlhhs.....................uupshhh................................hshhthhhthttt.............................................................thplslposshhh............................tchlctltchs...........hstlslslcshspp.........................htchh...pttsh........cphhcslcthpcts......hp...........hhshhhhh.sps.p..pchtphhchl	............................................................................................................h..hhttCs.hp...........C.s.....a.......C.thst.......................................................................................................................ttt.pths...h.....c........c....l......h.......p........p........h.........p.........p........h..................h.........p.....................s.........h.........p........t........l..h..h.s..................................................G.G.p..s..t.h..h.........................................................................................................h..s..h..h..t..h....h.h.thtpt.............................................................................................t..thc..l..s..l...p..o..s..sh.h.h...............................tchl.p.t...l.tp.ts................hs.h.l..p..l...s..l...p...s...hspp..............................................hhphh......ptt..sh....................pp....h.h....c.s...l...c....t...h....p..p.t..s...........................h......................hh.hh.hh.h........s.....s........p..ph.......h.............................................................................................................................................................	0	6768	12613	16003
+770	PF02145	Rap_GAP		Rap/ran-GAP	Mian N, Bateman A	anon	IPR000331	Family	\N	21.50	21.50	21.60	21.50	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.25	0.71	-4.92	54	1221	2009-01-15 18:05:59	2003-04-07 12:59:11	10	45	216	7	719	1143	3	181.80	35	14.83	CHANGED	lhsNppu..S..sapcFLshLGpp.................................VpLps..ap.tapGGLDspss..psGpao....lYhphc.........spElMFHVoThhPh....sts...............DtQplp+KRHIGNDhVsIlF....sE.ssps.as..................................shItSpFs...alhlllpsh....................ps...................................................hY+Vplhp+...sslP..FGPhhs.sthl.p..c..shtsalhspsINAppsshph.....spasphh..pcph.phlc.......sL	................................hhsNppu...S....sap-FLs.hLGpp.................................lcLcs.....ap....ta.p..G..GLDs.p.ss..pTG...ppo......h.Y..hs..h.p.........shElh..FHVSThh..Ph....p.ps......................cp.pp...lp.........+KRHIGNDhVsIVF.........pE....ssp...s....Fs.................................................................sh.I..t.SpFp.........alall..l.ps..ht...........................s...................................................................................................................hYpVsl.p.p+.......p-..VP.....hFGP..s.....hs.....s...s...hl..t.+..........thtpalhsphINAppAshps..........tpatphh..p..cph.thlcp...........................................................................	0	262	341	531
+771	PF04078	Rcd1		Cell differentiation family, Rcd1-like 	Wood V, Finn RD	anon	Pfam-B_5278 (release 7.3);	Family	Two of the members in this family have been characterised as being  involved in regulation of Ste11 regulated sex genes [1,2]. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation [3].	27.60	27.60	27.80	28.90	24.60	27.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.59	0.70	-5.56	27	453	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	304	4	291	421	6	238.70	58	77.46	CHANGED	phltcLt.pPcp..REpALlELSK+REpascLAshLWpShGslusLLQEIlulYPhLs.........PPsLos..ttSNRVCNsLuLLQCVAS.Hs-TRthFLpA+IPLaLYPFLpTsu+sRs..FEYLRLTSLGVIGALVK.sDcsE....VIsFLLpTEIlPLCLRIMEhGoELSKTVATFIlQKILhDDtGLsYlCtTsERFhuVupVLspMV...tpL...spps.os........RLLKHllRCYLRLS-Ns....................RA+cALpphLPptL+..DsoFsshlc-..Dsss++hLtQLLhNlsst	........................................hl.-Lh.sspp...REsALLELS....KKR..E.p....hs-.LA.hLWaSF...G............shsuLLQEIlslYPh.ls.........Psp..Lou...ttSNRVCNALALLQCVAS.Hs-TRshFLp.................A...............HIP.LaLYPFL.pTsSKoRP..FEYLRLTSLGVIGALV.K..sDsp-.....................VI..sFLL...............sT.EIIPLCLRIM.E..s.G.SELSKTVAhFIlQKILLDD............s..........GLsYICtTh.ERFh.tVutlLupMV...hpL............scps....os..............................RLLKHllRCYLRLSDNs....................RARc.AL+.p.CLP-....L+.......DsTFs..psLc-....DssTK+hLtQLLhNlp.s.....................	0	108	166	239
+772	PF05177	RCSD		RCSD region	Guo JH	anon	Guo JH	Family	Proteins contain this region include C.elegans UNC-89. This region is found repeated in UNC-89 and shows conservation in prolines, lysines and glutamic acids. Proteins with RCSD are involved in muscle M-line assembly, but the function of this region RCSD is not clear.	25.00	25.00	27.70	25.50	19.50	23.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.14	0.72	-10.92	0.72	-3.52	4	51	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	16	0	36	64	0	87.60	41	11.71	CHANGED	cV+SPsKKEKSP..............EKoEpp.so......EEsKos..KEKSPEcsDtp.tSPTKK-KSPppSusE...-lKSPsKKEKSPE...KsEccPuSPTKKE............psppcEKSPE	....................................................tKp.pp....tss......EcsK.sspK.cc+S..sEc.s.-c...pshSPs.KK-K.SPppS.usE......cs+SPsccctusE...csE.c..uo.sKcE.......................p..................	0	7	13	33
+773	PF01030	Recep_L_domain		Receptor L domain	Finn RD, Bateman A	anon	Pfam-B_244 (release 3.0)	Domain	The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix [1]. This Pfam entry is missing the first 50 amino acid residues of the  domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.71	0.71	-4.10	68	2555	2009-01-15 18:05:59	2003-04-07 12:59:11	19	86	174	80	1269	2434	30	112.50	25	20.58	CHANGED	sCohlpG....sLpIphtstp......................t..thlsslcclsGhlhItps..thpshshhpsLchIcGpphhp......paulhlhpN.p...............LpcLth.s..LppIpp.........GslhlppNs.......cLChtpp.h.hphlh	.........................................................sCohl..p.G.....sLplh.hstp........................................phphh..p..slcclo.....Ga..lhIpps......thss.h.s.hhp.N.Lph.....I.....+..G...p.p..l.hp.........................pau..Lhlh.pstp.............................................LppL.t.h..s......L.p.p....l.p..............................Gtlh.hp.p...N............pL.Chhp.p.h.h....h.................................................................	1	289	375	1023
+774	PF02010	REJ		REJ domain	Bateman A	anon	Bateman A	Family	The REJ (Receptor for Egg Jelly) domain is found in PKD1 Swiss:P98161, and the sperm receptor for egg jelly Swiss:Q26627.  The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.36	0.70	-6.17	25	1075	2012-10-03 16:25:20	2003-04-07 12:59:11	10	184	317	2	592	1109	109	274.00	15	21.55	CHANGED	Aplpl..pC....sstpspapWplhsssssssh.phsp.....................t..plsIPphsL....hGsYshsholoh.....sssslsspptsplplts.....osLhAhIcGGopcshuhp..pslh.........lDu.SpSh...DP...........Dhsstp...sslsatWhCpspsss........................................tsC..........t.t.h.hssssuslolsuspLpussp.YpFplslsKsu.....R.oupoppslhlhpGpsPplplpChssss.t...lssssclsLpusss.sss...sppspapWsl...........ps.tt..hh.....................................................................................................................................................................................................upssTshssstLsl+tsshpsstpYthslhltssshpt......hAshshps..NtsPpsGsCsl............sPspG...hsLpTpFslpCpsapDp-t.......PLsYphhh.............hpsps.hphlhpGspspp.....thhLPsG.ssp.taslslhVpVhDshGuss.ssshslpVpsssssss.........hh.hh.tssstlsshltpGDstputphhss	.............................................................................................................................................................................................................................................s.........h..htl...........................t...h..spt.h.......l.....l.........................t..s.............s.h..h.....s.s...s....t.hh.hshs.......psl.s...........................................Ls..G..otS.......Ds...........st............lp..apWppss.ssts..................................................................................................................................................t..tp.s.sh....hph...sp.h.....t......st.......hpF.p...lplpcsp.................t.sstsph...sl..h...s.............t.......................h........................................h...t.......h..h.h.....t.....................h.....h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	318	363	454
+775	PF03432	Relaxase		Relaxase/Mobilisation nuclease domain 	Finn RD, Mifsud W, Bateman A	anon	Pfam-B_4002 (release 6.6)	Family	Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation. The relaxase, in conjunction with several auxiliary proteins, forms the relaxation complex or relaxosome. Relaxases nick duplex DNA in a specific manner by catalysing  trans-esterification[1].    	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.43	0.70	-4.98	17	2990	2012-10-02 18:54:05	2003-04-07 12:59:11	9	15	1395	0	379	2707	170	226.00	16	49.85	CHANGED	spsShsphlsYhpp...........................+shppsshp...hsschstpphhsspthas........cs........psspsacll.SFpssE..ss......cphppluhchhpplu..saQhhlhsHsD....p-plHsHIllNplchpo...G+phpsp............h..shcplccsscplspccGhphspt........st.+.s.s-tshhp.......................scsphctph+pslcptpt....spsap-h+ctLpcpGlclc..thsspplshphpspp..ppl+usplucc..ascsplcpchtcp	.......................................................................................................t.....................................................................................t..h..............p.....h..................t.....t..........t...............................................pt.......................pt..sh..H.hhhSap...s....t.-...hss....................................cph....p....p....l....u.p....c......h....h....p...c..h.........t.....h.........s......p......a......p........a....l.lsp.H...p.D..............ps....+.......hHhHIlh.s.pls..pt...............G..+ph..p.sp............................................h....shcp.h...p..p.h...s...c.c..l.p.p....c...h.Gl...phspp......................t...p..p......p....h....t...pht.hhp..............................................................................................ttt.p...h...c..t..t...l...p.p.....t...lp.thht..........t..psh...p.p...hhp...h.h.t.p.....s.h..plp............tt....t...............h..............h................t..............................h....p...p..t..h.ttt....h.............t.......................................................................................................................................................................................................	0	137	269	341
+776	PF03090	Replicase		Replicase family	Mifsud W	anon	Pfam-B_2424 (release 6.4)	Family	This is a family of bacterial plasmid DNA replication initiator proteins. Pfam: PF01051 is a similar family.  These RepA proteins exist as monomers and dimers in equilibrium: monomers bind directly to repeated DNA sequences and thus activate replication; dimers repress repA transcription by binding an inversely repeated DNA operator. Dimer dissociation can occur spontaneously or be mediated by Hsp70 chaperones.	20.10	20.10	20.10	21.20	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.56	0.71	-4.31	15	361	2012-10-02 15:26:12	2003-04-07 12:59:11	12	7	242	0	25	357	7	124.40	36	38.95	CHANGED	sulhhps+psALcp+YIQsNtsphsshLVhDlD+s..sA..............ththtctst.sPNhhstNssNGHuHLlasLs.PVpss-t.ARpKPlpYhAAlppuLpptLsuDhuY.SGLlsKNPtHs.......pWpspphpsc....YsLccLuchL-	..........................h.thhhts+thAlt.h.YhQhNp.sthhtaLVaDlD+t...su.................lsWp.-tshPsPshhsp.......N.p.s...G......Hu..pLhYuls.s..V.p.....ss.....ps.....ucsKslp.....YhtAlppuhst.+L...s.A.....DssY.uGhlsKsPhHs.........................tWpshchppcs...YpLs-LAshl-..........................................	0	6	14	24
+777	PF03248	Rer1		Rer1 family	Bateman A	anon	Pfam-B_3358 (release 6.5)	Family	RER1 family protein are involved in involved in the retrieval of some endoplasmic reticulum membrane proteins from the early golgi compartment. The C terminus of yeast Rer1p interacts with a coatomer complex [1].	21.60	21.60	22.10	22.20	19.90	21.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.21	0.71	-4.69	34	427	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	311	0	286	395	2	163.90	50	84.44	CHANGED	sslsphhp+hpppYQphLDcosPasthRWhshshLlhlFhlRlhhhp.GWYlVsYuLGIYLLNLFLuFLTPKhDPuLpppp...t.-tG................LPt................cps-...EFRPFIRRLPEFKFWasss+AhhluhhhoaFshFDlPVFWPILlhYFIlLFslTM++QIp..........................................HMIKY+YlPFshG.Kt+Ystp	...............ss...thhscltphYQtaLD+.........oTPasthRWlsshslhhl...ahlR..lh........hhQ.GaYI.........VsYuLGIYlLNLFlAFLoPKh..DPslptpp.....ptGs..................sLPo...............................+ps-...EF.RPFIRRLPEFKFWausT+.AhhluhhhTaFph....FslP.VFWP...ILlhYalhLFslTM+RQIp..........................................HMIKY+YlPFshG.Kt+Ytt.p.............................	1	98	166	240
+778	PF02453	Reticulon		Reticulon	Mian N, Bateman A	anon	Pfam-B_2196 (release 5.4)	Family	Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologues.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.94	0.71	-4.65	90	1346	2009-01-15 18:05:59	2003-04-07 12:59:11	12	20	297	3	619	1288	1	158.90	25	44.60	CHANGED	ssDllh.WRch+touslhuushs..hLhp.l..tphsllolhspl.hlhsLssshshphhtpllps..............h...clslsc-thpphssslhthlNpslppl+clh...hsc-lhpolp.hsshhallohlGuhhshhTLlhluhlhhFolPllYc+apcpID...phlt....hspsplpc	.........................h-llh.W+ch+..t..ouhlh..uushh..hLh..p...l.....hthol....lolhuhl...hlhhLs.sshs....h...p..l..h..p...p..llps..t............................ht....pls.l.sp......-.....t......hp.......phsss.l..htpl...Np...slttl+.c..lh...hsc...D...h...h.p............sl............p...h.s..l.h.h.a...llohl.G.u..hhs.sl.TLh.h.luhlhhao..lP.h.lYcc..hpspIDphlt.......hsppph..p........................................	0	125	283	450
+779	PF04527	Retinin_C		Drosophila Retinin like protein	Waterfield DI	anon	Pfam-B_4914 (release 7.5)	Family	Family of Drosophila proteins related to the C-terminal region of the Drosophila Retinin protein. Conserved region is found towards the C-terminus of the member proteins.	22.20	22.20	22.50	22.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.51	0.72	-3.98	18	168	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	19	0	91	157	0	73.70	44	54.73	CHANGED	lhpEPsVA+VGslV+slPoAVSHQSpT.VHs.pt.lhpPVl......APsVKsT.lhp....sPl..s.........................tAAPll+s	................llpEPslA+VGs..V..V+olPo...AVSHQStT.VHs.pt.llp.PVV.......AP..lVKoT..hhs......uPllts......................tuAPll.....................................................................................	0	17	20	58
+780	PF03732	Retrotrans_gag		Retrotransposon gag protein 	Finn RD	anon	Pfam-B_3194 (release 7.0)	Family	Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.19	0.72	-3.92	57	4914	2012-10-02 13:37:57	2003-04-07 12:59:11	12	294	205	0	2568	5331	10	92.40	19	10.14	CHANGED	phhshtLputAtpWapslhsspht...............oWpphpptFhppahs.tphsphppclhslpQ.sscolpEYhpcF.cplhppss......hsc...................pshlptahpGLpt	...........................................................h.htLp.s..A.t.tW.h.p..p..h..ppht..................................oW...p...c..h.p..pt.F...hpp.F......h..s...s....t...tt.s.t..t..c..p.p...l.p...s...l....p..Q..s...sc..ol.p-Yh.pcF..p.p..lt..p.ths..........hsp..........................t.hh...th..ah.tGh......................................................................	1	853	1171	1588
+781	PF01694	Rhomboid		Rhomboid family	Sohrmann M, Bateman A	anon	Pfam-B_1399 (release 4.1)	Family	This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes.\	\	Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor.  Analysis has shown that Rhomboid-1 is an intramembrane serine protease [2][3][4] (EC:3.4.21.105).  Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite [5].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.89	0.71	-4.17	65	7854	2012-10-01 23:21:32	2003-04-07 12:59:11	17	73	4018	16	2797	6356	2105	148.00	23	48.95	CHANGED	shtpsphWR.....llTshalHs..hhHlhhNhhsLhhhGh.lEphh.....GphRhhhlYlluGlhu...ulhshlhssts......................tlGASGulaGllGuhhshhhhshhhhh................................hhlhhhhhhlslshshsh...hstlshhu...........................HluGhlsGhhhuhhlhtthp	....................................................h....phaR......llo...sh.F..l...H.........h........u...........h.......h.........Hl..hhNhlh....L....h.............h.....h.Gth....l...E....p...h..h......................G...p.....h....+h......h.h....l...a.l.....l...uu...l..hu..........ul.h....p....h....h...hss.s............................................................hlGASG..u.....l...a....Gl.....h.us.h.h..h...h..h.h...t.s.t.t.h.hh..........................................................hhhhh.h.h.h.h.h.....l..h.h..sh.h.hsh.............hs...s..l..s..hhu............................................................Hl.u..Ghl...s..G..hhhuhhh.....hh.............................................................................	3	991	1753	2345
+782	PF05104	Rib_recp_KP_reg		Ribosome receptor lysine/proline rich region	Finn RD	anon	Pfam-B_3249 (release 7.7)	Family	This highly conserved region is found towards the C-terminus of the transmembrane domain [1]. The function is unclear.	25.00	25.00	25.80	25.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.36	0.71	-3.69	6	77	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	30	0	24	79	0	127.50	54	14.53	CHANGED	MKETSYEEALAKQRKEpuKTQ.ptKsDKKKK-KlsEKKsKuKKKEEKPNGKIPEpEsstEsocp........llltppP..sPsVsssPspVsls...PsVAshPcsotPs.opcpsuuP...tKuss..sPpspppKppKsA....KstPAPsptussP..hsuKuAPlsAp	...MKETSYEEALApQRKEhuKTp.ppKs-KKKK-K.ssEKKsKsKKKEEKPNGKIP-p-ssspso..........................lh.ppP...sPsVslsPssVt.........s.lh.tPhsssPs..s.pcchsus...........Pp.cpppKp.pKs.A........KscPAsuphsss..h.ssKuA.h...s.............................................................	0	2	6	11
+783	PF00636	Ribonuclease_3		Ribonuclease III domain	Bateman A, Finn RD	anon	Prosite	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.55	0.71	-3.63	239	3186	2012-10-03 08:45:47	2003-04-07 12:59:11	21	88	1836	63	1255	5519	1999	113.60	26	26.36	CHANGED	ppLtaLGDullchhlpphlh...........................tspLsp........h...psthV....sspshu..phsp............p.......................................L...tp....hlp......................................................................................................................................................................t...................phhusshEullGslaLsss	...........................................................................................................pLtal.G....DAl..hchhlpp.aLht........................p........sph..c.......................sspLpp.........h....ps.phV.......ss.cs.Apl.h.t..........................p........................................................................hh.......................h..pp........hl.p.p...pp......phhcptcs..................................................................................................................................................................................................................................................................................tpt.tt..p.......pssht.sh.phu..sshEAllGhlalst.t................................................................................................................................................................	0	428	728	1043
+784	PF04597	Ribophorin_I		Ribophorin I	Kerrison ND	anon	DOMO:DM04452;	Family	Ribophorin I is an essential subunit of oligosaccharyltransferase (OST), which is also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase, (EC:2.4.1.119).  OST catalyses the transfer of an oligosaccharide from dolichol pyrophosphate to selected asparagine residues of nascent polypeptides as they are translocated into the lumen of the rough endoplasmic reticulum.  Ribophorin I and OST48 are though to be responsible for OST catalytic activity [1]. Both yeast and mammalian proteins are glycosylated but the sites are not conserved.  Glycosylation may contribute towards general solubility but is unlikely to be involved in a specific biochemical function [2] Most family members are predicted to have a transmembrane helix at the C terminus of this region.	25.00	25.00	27.80	25.30	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.41	0.70	-5.97	40	386	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	288	0	244	366	1	397.90	32	80.96	CHANGED	sacNssltRsl-Lspsal+pohplslc.....Nhu...spP.tscYhhshss..c.hspluhlssp.ps.spttsph........slclppsp..t...........aplpLPpP.ltPusplslplp.ashspslpPhPspIsQs-pQhlhapssta.hhSsYtTcp.Qphpl+hs.sspl.saTpst.............sspppssslsYGPa..pslsu......aohpP.ltl+YEpspPlsplspLpRsIEV..SHW.GNlshEEpYpLpNsGAcLputFSRl...-appsphp................................................sssulpplchhLPs..supDhYYpDplGNlSTS+hpsspt.h.....................Lcl+PRaPlFGGWpasFslGashshppaL+psust..pYhLplPhlsuhp...-shh-plplcllLPEGApslclps.........P.hshtptphshchoYLD.ThGRsslslphpNls...--tp.pplhVpYca.......sthshhpKPlhIsuhhahlFluhhllsp	.............................................................................h.s.sl.RplcLpp.ph.s+.shplhlp........shs...sps...spah.hsh.s........p..hspluhlpst.pttpptt................hphtt.tp..th.......................................................aplpLsps.ltsutphslhlp.hhhspslpPhPtpIsQ.s.-..p.Qhlhapssta....hhS.sY.Tpp...Qphpl+hs...ospl..s.aTphs..................................sspppssplpYGPa...cslss........ho.ps..hpl+aEpspPhhslsplp.R.sIEl.....SHW.GNlulE...Ephp.LppsGApL.cusFSRh...-appp...t................................................shsulpphchhLPs..uup-sYYpDpIGNlSTS+hh.tp.cpsp....................l-l+PRaPLFGGW+hpahlGYshP..........pa.Lhptss..........pahLph.hlstlh...sh.sh-plpl+llLP.............EGAcslclps...................P.hslpptt....p.h.chTYLD..ohGRsslshptpNll....-pah..ppl..hVpYsa.......st.hhhLp..cPLh.lsu.shahlFhsshlhh..............................	0	87	140	202
+785	PF01775	Ribosomal_L18ae		Ribosomal L18ae/LX protein domain	Bateman A	anon	PSI-BLAST Q02543	Domain	This family includes eukaryotic L18ae as well as archaebacterial specific LX.  Ribosomal protein L18ae forms part of the 60S ribosomal subunit.	22.90	22.90	23.50	22.90	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.37	0.71	-4.23	63	714	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	512	7	414	682	35	104.30	44	66.40	CHANGED	l+pYpVhGchhss...........................................................................................................................p..................hsshcshhKEhRshsppsAl-phYs-hGu+H+s+tppIpIhcVp	............................................................................ppYpVlGRtlPo....tt.t..s.la+M+lFAsNplhAKS.....................................................................+FWYFlppL+KhKKusGEllthp..l..............................hE+pPhplKNa...G.I....W....l.R.Yc...SR.oG.p.HNMY+EYR-hohsuAVpphY..........p-MuuRHRsRhp..sIpIl+V..........................................	0	140	231	342
+786	PF00828	Ribosomal_L18e		Ribosomal protein L18e/L15	Bateman A, Finn RD	anon	Pfam-B_1295 (release 2.1)	Family	This family includes eukaryotic L18 as well as prokaryotic L15.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.86	0.71	-3.77	104	6291	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	5075	302	2015	4096	2465	118.70	35	75.86	CHANGED	Ghhtppct+sp+ut+sp........ppc.ha.th.h....la+hlu+.+....sFpp.hh...hhsphphssl...........................Nls+L.p..thhtts.........ssc.hllshuhl.......ts.hKlLGtGtl..phs.lsVpAhphScsAcp+IcpAGGpshhh	........................................................................s...GKTuGR..GpKGQ+uR.uGs.......ts+h......GFEGGQhP....LaRRLP.K.h...........GFss.hh...........phs.V....................................NLscL..s...p........t..ps................ls.p..sLhtsullt.......................tshlKl.L...u.........s...G............c......l...s........p.t....ls.V.c........u........t.phS.cuAcpt.Ic.uAGGplp..h...................................................................................	0	703	1254	1677
+787	PF01907	Ribosomal_L37e		Ribosomal protein L37e	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes ribosomal protein L37 from eukaryotes and archaebacteria. The family contains many conserved cysteines and histidines suggesting that this protein may bind to zinc.	24.50	24.50	24.70	25.00	23.00	24.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.92	0.72	-4.17	46	667	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	505	75	372	579	23	50.80	56	57.37	CHANGED	sKGTsSFGK+pp+.oHhhCRRCG+pSaHlpKcpCAuCGassu+ph.pYs.WspKshc	...................sKGTsSFGKRpsK.oHsLCRR.C.GR+SaHlQKpsCuuCGYPuu+pR.cYN.Wu.KAh................	0	138	223	305
+788	PF00347	Ribosomal_L6	L6;	Ribosomal protein L6	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.30	21.30	21.40	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.42	0.72	-3.48	132	10746	2009-01-15 18:05:59	2003-04-07 12:59:11	18	5	5013	462	3006	6705	3987	74.40	26	80.83	CHANGED	lshG.hclphps.....plhhshG.pt....lphphsps.lplph......phshhhh.puhc+pp.........ltphRshhs.hs+Glp.G	..................................lssG.hc.s.phpG...........pllhshG.p.ts..........lphp.h.s.ps...lpl.....p.h.......................................p........h....s........hhh....h...p.........G...t...c...+.phs...................thtshRs..s.h.scGVp..........................	0	982	1857	2473
+789	PF02482	Ribosomal_S30AE	Ribosomal_S30;	Sigma 54 modulation protein / S30EA ribosomal protein	Mian N, Bateman A	anon	Pfam-B_869 (release 5.4)	Family	This Pfam family contains the sigma-54 modulation protein family and the S30AE family of ribosomal proteins which includes the light- repressed protein (lrtA) (Swiss:P47908) [2].	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.14	0.72	-3.55	144	5238	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	4060	21	1172	2968	717	96.10	30	63.58	CHANGED	plploG..+p.l-lo-ul+palpc+ls+.lp.+ah.s....ph...hp.sc..Vhlsht.........t....ptpsElol.hh..sGh..hlpAps.pspDhYuAIDhss-KL-+Ql++aKc+..hp.s+	..................................hsIpG..+p.l-.lTcA.lRpaVppKl..s..K..LE..+ah..s...pl......hp..sc...VhLps..............pp.p.stp...sEs..Tl...h...sus..........hlp......A......p..........s......p.........s......p....D.......hY....u......AID....hlh-K....L-RQL....pKhKcKhpp........................................	0	368	735	983
+790	PF01201	Ribosomal_S8e		Ribosomal protein S8e	Finn RD, Bateman A	anon	Prosite	Family	\N	21.30	21.30	21.60	21.80	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.67	0.71	-4.01	93	1149	2009-01-15 18:05:59	2003-04-07 12:59:11	17	11	591	7	655	1075	110	194.20	35	92.35	CHANGED	Muhscs..cp+R+tTGG+hcht+K.KRKaEhGRs.....................................................ss.T+l........u....tcl+plR.........................sRGGNp.KhR..............................uLRhcpuNhsasppssoc+s+IlsVhhNsuNschlRpsslsKGsIlplsss............-LG...............................................................................hAploSRPGQ...............sGhssuhll	.......................................Ms.sc.t.pc+R+tsGt.+hchhcK...KRKhEh.G.cs...................................................................sssTpl............up...ppl+phR...................................................................sRGGspKh+.................................................ALRhcpuNho..asptssTt+scIlsVhhNsSNsphsRpssL....sKusIlplsss............pLGhhttst...............................................................................h..hthhAploocPGQ...............sGpssuhlL..............................................................................................................................................................................	1	231	377	536
+791	PF00652	Ricin_B_lectin		Ricin-type beta-trefoil lectin domain	Bateman A	anon	Prosite	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.45	0.71	-4.09	97	3906	2012-10-02 19:42:32	2003-04-07 12:59:11	17	272	770	168	1967	4763	232	120.80	19	22.78	CHANGED	ssshlpths..sshCLDst....tttpsssltlhsCss......sss..QhW...phsts......splpstst..........CLssssss..............s.ltlhsCps.ssst......QtWphps........ssplhstp.ss..hCL-stt.......sssplhlh.pC....sss....ss.QpW	...................................................................h.....t.ht...sshC..l-st............ttsst......l.t...lh.....s.Cps..............sss.......Q...h.a............th..s.t..s....................t....p....l...p...t..t.s...t...........................C...Lssssts..................s......l...tl..h.s.C....s......s...sss................Qp..W.phps.....................ss..p..l..h...ph....t..ss........hCLsstt.................sstt.l.hl....t...C....sts......s..QtW.............................................................................	0	706	1030	1517
+792	PF00355	Rieske		Rieske [2Fe-2S] domain	Finn RD, Griffiths-Jones SR, Eberhardt R	anon	Prosite & Pfam-B_31 (release 4.1)	Domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.08	0.72	-10.67	0.72	-4.42	146	13057	2012-10-02 12:49:59	2003-04-07 12:59:11	21	95	3458	318	4393	11916	6165	94.20	19	31.33	CHANGED	sahhlsppsclsp....sshhhhph.spp.llht.stcGphhuhtshCsHtGsh................lsts....tp......t......hpCshHGhpashp....GplhpsPs................hpth.sthphs	.................................................................h...tpl.t............t.h..h.h...h........h....s....t.....t.........l..h...h...h....s........t.........s.....u...p.........l..h..uh.ts.hCsH..t..G.s........................................................lst..s.....ttp..................tt.............th.hCP.hH...G.h....pash.....s......Gph....h.p....s.Ps..t............................tt.....................................	0	1183	2635	3671
+793	PF00866	Ring_hydroxyl_B		Ring hydroxylating beta subunit	Bateman A	anon	Pfam-B_771 (release 3.0)	Domain	This subunit has a similar structure to NTF-2 and scytalone dehydratase.	20.50	20.50	20.50	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.64	0.71	-4.51	44	1346	2012-10-03 02:27:23	2003-04-07 12:59:11	13	2	779	109	317	1106	162	141.90	28	83.48	CHANGED	+EAcLLDs.....pcacpWhs.lhs-DlpYahPhppsc.ptsps............ptshhas-s+ttLcsRVtRlposhuWupsPsoRTpHhloNl.ltts.psssplcVpSsahlaRsRhc...tpschasGpppchLRpsssu.....hclspRpllLcpssl.sp	...........................................................pEApLLDc.....tcaccWLs.hhs--...h.pYhhPspss....ttphspc.th................hshla.p-s+stLccRlhRl.c.o.shua.u.p.p.PssRT.pHhl.oNlp...l...h....pt.....t.......p.....s...s....t...........hp.VRsNahlh.c.sRtc...........p.ps.h.a.s.Gpp.h.cplccss-s.........h+lhc+pllLcpshltt...................................	0	51	148	245
+794	PF04068	RLI		Possible Fer4-like domain in RNase L inhibitor, RLI	Kerrison ND, Finn RD	anon	COG2042	Family	Possible metal-binding domain in endoribonuclease RNase L inhibitor.  Found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, fer4, Pfam:PF00037. Also often found adjacent to the DUF367 domain Pfam:PF04034 in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons [1], and could possibly play a more general role in the regulation of RNA stability in mammalian cells.  Inhibitory activity requires concentration-dependent association of RLI with RNase L [2].	20.60	20.60	21.20	21.20	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.63	0.72	-4.36	80	889	2012-10-03 08:56:42	2003-04-07 12:59:11	10	13	472	2	602	859	65	33.10	36	7.40	CHANGED	h+lAllch-....cCc.PKKCst.cht+hssl......s+sGcp	..........+lAlhsh-................+Cc.PK+Cst.cht+hs.l......lRhGp............	0	200	348	505
+795	PF04437	RINT1_TIP1		RINT-1 / TIP-1 family	Bateman A, Wood V	anon	Bateman A, Wood V	Family	This family includes RINT-1, a Rad50 interacting protein which participates in radiation induced checkpoint control [1], as well as the TIP-1 protein from yeast that seems to be involved in a complex with Sec20p that is required for golgi transport [2].	24.80	24.80	25.20	25.10	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	494	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.68	0.70	-5.95	19	318	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	250	4	239	330	2	430.90	22	62.61	CHANGED	hsl-hhlpPlclRFpYHFoup+.Tspl-K.PEaahshlhchlss.ssFhspplQPlhDc........hthshhss+ppFIsull.hlpcKlsspl..................plppc.phhsHLlcEllsFDpcl+psasY.s...............h..slplLs.cpsha-+WlplEcchAls+hcthlps.cshphp.pt.............l.sshssh+sscsAtph.cLLpslh-RhpsLsshs.clpFLhslQlplhcpFhppLppth.th.h................tphpssssL.+hspllsuspYlpphlc-WuscVaFl......p.t...............phscluscsou..................lFD-shsshc+.lchchpshIssslhcshcsth+sYh+.hspWsohssp......stt.shssSu.-lssshphLpsplshLppt.Lshsshtplh+plhtslppalassllhts.pFSpuGusQhthDh.cpLhslhsh..........stpspthhp+LsEulhLLsLphsts...tphh.tt.tc........................spsspshLsEl..ulppLop.........s-spslLpRRs	...............................................................................hshphhhpPhthRFp...aHF.p.u.p.+...Tshhs......K.....P.....E.....aahs.lhphhpph.thhtphlpshhsp..........................t.....h.ss.h.pa..hpull....hlhpKltt..l.....................................................................p.h.tps..thhsHhlpphhtF-pp.lp.......ph....asYss.......................................................s.shplL.....ptp..h....h..ppWlphEpc....hAhp+hp.t.h.h.ps....ssh....p...p...........................t..s.ph+..ss.sA.phhpLLpslp..........c+.apsL.phs.clpFl.plQhtllcpah.pLhph................................................................tt.pt.sth.phstlhsuspaltphl...p-Wup..p.hhFl............................p..............................thtphss.ptss.....................................................................lF-phhs.hpp.htpph.p.lhp...tlhpphptth..+sYhp...ppW..sh.tt................................hs.Ss.phs.hlt..hLppplt.Lppt.Ls.hs..........hhth.hptlhptlsphlhp.pll....h......ts...pFst.........sGstQhthDh.ps..lhslhp....................ht...p..s...p...thh.pl.p.-uhh.lLs.h..ht.t..................t....t...................................................................................hpthhtph....t.l.t..ls..........tph..lL.hh....................................................................................................................................................................................................................................................................................................................	0	83	134	198
+796	PF01163	RIO1		RIO1 family	Finn RD, Bateman A, Wood V, Mistry J	anon	Prosite	Family	This is a family of atypical serine kinases which are found in archaea, bacteria and eukaryotes.\	      Activity of Rio1 is vital in Saccharomyces cerevisiae for the processing of ribosomal RNA, as well as for proper cell cycle progression and chromosome maintenance.  The structure of RIO1 has been determined [4].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.31	0.71	-4.95	28	1707	2012-10-02 22:05:25	2003-04-07 12:59:11	17	19	847	16	1056	4738	997	172.30	27	45.74	CHANGED	sVYpuhs.....tsup.....................phAlKla+sutssF+c.hccYlss-hRap..h.+tsh+pllchWAcKEa+NLpRltptG.l.VPcPlshpcplLVM-alG.tpGhsAPpL+-sp.......tcscplatcllp......hcthYpcspLVHuDLSEYNlLlpcs.clhlIDhuQuVphs.HPpAhpaLcRDlpNltpFFc++uss....hhshcpl	.............................................................................................lahs.s........pt.......................hshKla+.......h.......s.h............h.......t.......F+......p.......h.......cph.......h.......s....h..........p.......h.......+.....................h.p...p...hs.......h...h.h......c....h....h.s........p...+...E.hp...sL.t............p..........l.....t.....p...........s..................G.......l...............s......P...c.........P........l........t.........h..........p..........c......p........l........l......l...M......-...h....ls........................G..........h.....s.....h....s....p....L......p.-.s.p.......................tp.h....t...p........h...a...t..p.llp................hh...t...h.....h......t..ps.....s.......LlHu...D..L..S.E...a...N.lL..l...............p.............p............s.....p..............h.....h..lI...D..h...s.......Q..s...V..........ph.....s....p.......s.............p..............A..............t.........h........h..pR..Dlpslt..p.aFt+hh..........h..................................................................	1	337	599	872
+797	PF01000	RNA_pol_A_bac		RNA polymerase Rpb3/RpoA insert domain	Finn RD	anon	Pfam-B_172 (release 3.0)	Domain	Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal	21.30	21.30	21.40	21.70	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.56	0.71	-3.91	59	7300	2009-01-15 18:05:59	2003-04-07 12:59:11	21	25	6097	183	1610	4907	2300	120.20	33	38.59	CHANGED	VpI..su.......ltHchuhlshlpEDlhc....hlh.hKth...............psp-ps..hlpLpspGsup..................VhAuDlph............sssVcll....................ss-hhIspLscstc.lchchpsccGhGhs.Ac....................ao	.........................hph..............VhHEa..SolsGV..pE.D..V.hc....IlLNl.Ktls....h.......................psppcp......hlplshp.Gsu.................................VTAuDIp.h....................................................sucVEIl....................................................N..P-.hhIssL...s..c............s.s..p..lphclplp+GRGYlsAp..tppptt.....h...........................................................................................................................	0	566	1019	1357
+798	PF04997	RNA_pol_Rpb1_1		RNA polymerase Rpb1, domain 1	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 1, represents  the clamp domain, which a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [1,2]. 	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.06	0.70	-5.18	24	12239	2009-01-15 18:05:59	2003-04-07 12:59:11	7	127	9183	179	1981	10137	4485	254.70	33	31.57	CHANGED	h+clcplpFulhSP-pI+.phShsclpps-ohp.sp...pPcpsGLhD.+lGs.........hcpch.............hCpoCthphtc...C.GHaGHI-LspPVaHIGahctlhplLcplChhCuplhhsppt......hhhp.t.......thsphp+hphlsphstppshpcts...............................................................thtp.pshhtc.G.hslhthhc........tcphpcpht......hps.pshplhc+Isccchhlhuhsspts.+P-hhILoslPVPPPslRPuV.h-utp...hu-DDLThpltcIlppNppL++hppp.uAPptllpcphphLQ.plsshhDN..thsuhs.st.pssRPlKSlspRLKGKpGRhRsNL	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..phGaIcL.s...P.l..Hl.......h.ah..pt.l.p...ch....s..h.h..........s.h...........t...hp.........s.........-......p..............h..........h..h..h..ht...........................ss.h.p.p.h.ph......l.h....p......p.....h...h...p.....h...h...p.c...hs......................................................................................................................................................................p...............t....t......G...............t.l..h....t..h...hct......................t..pph....p...hp..................hp.s.tt..s...p....h....hp..+....h.........cc.............h.......h..........h.............u.......h...................t.........s..........h............s.........+..........P.........-.........W........M.l.........l.s.l.lPV.PPslR....P.........l..l..D....Gut......hu..p....sDL...s..hhtc......l....Ip.......t.......N....s...............p......l..............p..+...h........................p.........................s....u.........P.................t..............h................l............l..p..................p...........................cp.........h............L...Q..........t.Vss.h.hDN......s.h...t.................s.....s.............h.........................t......t.....+.sh.Kuht..ph.lcGKp.....G.........RhRtsL.....................................................................................................................................................................................................................................................................................................................................	2	707	1252	1678
+799	PF00623	RNA_pol_Rpb1_2		RNA polymerase Rpb1, domain 2	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 2, contains the active site. The invariant motif -NADFDGD- binds the active site magnesium ion [1,2].	23.40	23.40	24.50	23.60	22.90	23.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.15	0.71	-4.29	33	13383	2009-01-15 18:05:59	2003-04-07 12:59:11	15	145	9364	137	1887	9901	3260	133.80	57	17.84	CHANGED	GKRVDaSuRoVIss-PsLclcplGlPhphAhpLphPphlsphNhcclpphh.pt.p.a.th..h..p.pus+phlptt.........s.plh.................tlhR+lhcuDlVLhNRQPoLH+hSIhuHcs+llpt...+ohRLp.sVCssYNADFDGDEMNlHlPpo.pA+uEuhpLhhs	.............................................GKRVDYSGRSVIlV.GPp.LpLaQCG..LP+c.hAlELFps.Fllp.tL....t.pp...lAs...................................................................................s....l........t..s..........A.......K.....ph......lccp................cs..hVW............................................................-lLpEVh.p..sHPVLL.....NRAPTLHRLGIQA..........FpPh....LlEG......+AIpLH.P.LVC....p.uaNAD...F...........D........G.DQ........MA.V.H.V.PLShEAQuEARhLMh.s...............................................	0	671	1188	1598
+800	PF04983	RNA_pol_Rpb1_3		RNA polymerase Rpb1, domain 3	Bateman A	anon	Pfam-B_288 (release 4.2)	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking [1,2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.91	0.71	-4.50	112	9996	2009-01-15 18:05:59	2003-04-07 12:59:11	13	133	7655	137	1909	7790	3140	147.50	24	14.34	CHANGED	pIloPpsGcPlhussQDhlhGsYhlTtcc.........................sFhspp-shphhtts............................................................................................................pssIhhs.pt....................................haou+phhuhll.t..............pl.hpph..............................s.hhlppu.lhts.lsct.hu........tpshusllphlhcchG.ptssphlsplpplshtahtptG.holGlsDh	..................................................................................................................NllsPtsGcPlhsssQDhl...lG.hYhhThcp.........................................................................................hFhshpcsh.hh..h.................................................................................................................................................................................h..pst..l.hh....t..............................................................................................................hhhhc..p..hh...uhh.l.s..........................pl...th.........................................................................................................h.hlpps...h.................................s...........................pshupllphh.hp..c...........h....Ghp..ssthhsplppl....s.htahhh...tG.holGlsDh........................................................................................................................................................................	0	675	1204	1625
+801	PF05000	RNA_pol_Rpb1_4		RNA polymerase Rpb1, domain 4	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 4, represents the funnel domain.  The funnel contain the binding site for some elongation factors [1,2].	24.80	24.80	24.80	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.59	0.72	-4.31	106	8924	2009-01-15 18:05:59	2003-04-07 12:59:11	12	128	7522	137	1812	6872	2412	93.40	29	8.38	CHANGED	lppscc.scl...ph.upshccshc.....thhpph.hs..pc............tp.................NslhhMstoGu+GShhNlsQlsuhhG..ssps.p.........p.h.............php.h.ptPhspGFh	........................................................h....cchpcl.....sh.spstcpshc......shhspl...s.....p.pp..................t..t....t.t.....................................NslhhMus.SGA.+GS.............sh.....plpQlsuhhG.hu.........h.s.t.......................................h..........................................................	0	647	1141	1537
+802	PF04998	RNA_pol_Rpb1_5		RNA polymerase Rpb1, domain 5	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound [1,2].	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null --hand HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.68	0.70	-5.14	27	9187	2009-01-15 18:05:59	2003-04-07 12:59:11	12	161	6820	151	2086	7646	5482	395.80	25	36.28	CHANGED	GLsspEFFFHsMuGREGLlDTAlKTAcoGYlpR+LlKshEDlhlpYDsolRsustpllQhhYG-DulDshphcthshhhh.hhsh.hptphhhshtp.hhhttt.........................................................................................................................................hthh.csthtphplhp.hphsppthpphhshhpspappsllpsGEuVGhlAAQSIGEPuTQMT.LpTFHhAGsuupssT.GlPRl+Ellplspstppsshsshhhhshspcptphhthphttpphthtthhhtt.hhhs.s.tpshtpptt.hhhphhhh.pp.tpt.hh.......hh.......h.h......................................................................................................................................................h......t....t...p.hhtttttthhtpththpptppthshpthtthtphtth.hphhhhhtsspthhhthhhsptthsspshh.htstchllph.pGsslptlhp......hps...lpss+phoNp..lhphhchlGIEAuRpsllpElpplhttcGhtlshRHlsllsDhMThcGhlhul...oRtGlspp.pShh.h	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLsshEaFhpshGuRc.............G.L.s.DTAl+T.ApoG......YLpR..RLVcsh.p-lhlp.cs..s....s....p....p....p....s....h.........h.....h........h..h...G..t..-hhtsht.ch.thhhhp.hhts.ptthhh..tt.h..t................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.h.ttthpthhlpsshsppsp.hhshhshspshhptphlp...GEA....V.GhlAA...QSIGEPGTQhT.h+TFH.....h....u..Gs..u...s...t....s....................h.s....s..........p.......hp.p.......hp.h......p.................h...t..............h..t....................................................p....t....t..t......h....h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...h.h.....h......t.............t.....................t.......h.........................t.................h....h.....ht....p.....l.p.pV..ap.........pG..h..t....s+php.h..lp..ph..h..p.p..ht....l...t.s.t..p.o............h.h........h.p.....h...................h............s......ch...................h......t...................ht..hp.....lhu..l...T+.tu.ltpp..ohh..s.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	752	1323	1780
+803	PF04992	RNA_pol_Rpb1_6		RNA polymerase Rpb1, domain 6	Finn RD	anon	Pfam-B_288 (release 4.2)	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module [1,2].  This family appears to be specific to the largest subunit of RNA polymerase II.	21.10	21.10	21.90	22.40	20.60	19.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.11	0.71	-4.55	153	1575	2009-01-15 18:05:59	2003-04-07 12:59:11	9	78	1215	90	258	1468	151	157.90	39	18.62	CHANGED	hDGshlE.pQpl-slphSsp...pF-............+ca+lDl......s.spshh...........tshlptsh..p-l.tussc...h........QphL-cEacQLppD.....................RchLR......plhssu-.sphs..LPlNlpRlI.NApphF+...I....cppps.SDLpPhcllpsVcpLhc.+.LllVp..............................G....cD............................tLS.........pEAQpNATLLFphhLRSpLAsKRVlp.Ea+LsppAF-WllGEIEsRFppu	............................hDuhhlE..QplshlphSsp...tF-...................+ca+hDh.............s.spphh.......................pch..hp.s......p-l..hsshp..s......................p.L-pEa-pLhpD.....................RchLR.........p.l..h..sp....u-...pph................LPhNltRhl.sApphFp....l.......ptp.t...osLp.Ph.........c.....Vl.s...VppL...c+..hhlVt.................................G.....pD.............................lS.........hpApp.NATlLFphhLRSpLs.Kcl.sp.Ea+Lsp.AF-allGElEsRFtpu.................................................................	0	98	149	223
+804	PF05001	RNA_pol_Rpb1_R		RNA polymerase Rpb1 C-terminal repeat 	Finn RD	anon	Manual 	Repeat	The repetitive C-terminal domain (CTD) of Rpb1 (RNA polymerase Pol II) plays a critical role in the regulation of gene expression. The activity of the CTD is dependent on its state of phosphorylation [1].	20.30	6.20	20.50	6.20	20.20	6.10	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.46	0.74	-6.69	0.74	-3.36	99	4609	2009-01-15 18:05:59	2003-04-07 12:59:11	8	80	222	10	2717	4635	45	14.20	79	15.78	CHANGED	SP..s.SP.....s..Y..SP...o.SPsa	............SP..T.SP.......u......Y..SP.....T..SPuY..............	0	913	1434	2266
+805	PF04565	RNA_pol_Rpb2_3		RNA polymerase Rpb2, domain 3	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site [1].	21.00	10.30	21.10	10.40	20.90	10.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-8.99	0.72	-4.22	31	16867	2009-09-13 23:49:08	2003-04-07 12:59:11	11	131	12522	133	1834	13597	2855	63.90	55	9.45	CHANGED	Qhh-phN.loploHhR+lsh....Guls+cptshcsRclHsopaGhlCPl-TPE.GtssGLlssLuhhscls	.........................Qhhsph.s.lSp.loHhR..Rls............uuL..s.R-p..t.thc....sRclHsTHa....GhlCPhETPE.G..shGL.lpsLuhhupls....................	0	652	1156	1555
+806	PF04567	RNA_pol_Rpb2_5		RNA polymerase Rpb2, domain 5	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain [1].	20.40	18.00	20.40	19.00	20.30	17.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.28	0.72	-3.99	64	7512	2009-01-15 18:05:59	2003-04-07 12:59:11	12	60	5291	96	702	6482	353	64.00	49	13.61	CHANGED	apsLlppG..llEYlDsEEEEsshIuhs..th.......................................stp.sppaTHhEIaP	.............WcsLlcsG.....llEYlDAEEEETsMIsMTPEDL-...R..ptsh...............................................................ttt..p.hht.hsss..sHhaT..HCEIHP...................................................................	0	239	399	587
+807	PF00562	RNA_pol_Rpb2_6		RNA polymerase Rpb2, domain 6	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain [1].  The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex.  This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion[1].  This domain is also involved in binding to Rpb1 and Rpb3 [1].  Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).	23.40	23.40	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.31	0.70	-5.72	117	16703	2012-10-01 19:23:01	2003-04-07 12:59:11	23	139	12411	138	1943	12966	6003	307.10	35	46.19	CHANGED	slhAphhshspaspusRh.......................hhps...scps.t...................................................................hhshs.phpRssps.s...phsQ+P..lVpst.tlctsp..............hs-lshGpNslVAhhsasG.YNhEDulllscphlccshasSlahcp.....hps..........ccpc..hG..-chhpphsss...........scpshppL..Dcs....Gll.............................pl...................Gst......VpsGDlLlGKh.....s............hpthhsppspp.h+DsSlphtts..pp.GhV.cVtl.............................................................................................................................................................................................................................................p.sss.s.....hphl+VhltppRp.plGDKhuuRHGpKGlluhlhPpEDMPahp.cGh..ssDlllNPhGlPSRMsl...................GQllEshhGhAush...........................................................................pG.hhhssssFs...........................................................................................p..................ppl...............................tchLp.....................c.....t.....................................................................................Gpp..............hlasGpTGc.h.......cs.lhlGhhYh.KLpHhVs..DKhHAR.upGPhs..hl.....TpQPltG+up	.............................................................................................................................................................................................................................................s.hhuph.shl...sp......us+h.......hhts.....ttt.t.....................................................................................................................h.h..h.a.p.RoNpss.....shsQ+P..hVp..hs........l...ctsp............hs..........t......hs.ELshG.....pNhlVAhhsa.....pG..YN.EDul.........lhspp.l.cshapShahcp...h.............................p.pp...........t....p.c...hh.t.c..p...............................ttthhppL.D.c.p......Glh...................................................Gs.......l......t.t..c..lllu+h.................................................t.h...t..p......h+-...sh...h.....s.......t..Ghl....tl.h.......................................................................................................................................................................................................................................................................................................t....s.......hl+lh..hh.p+h.p...GDKhuuRHGp.K...Ghlu.........hhh.....pDMP..a..........pG.........h....s..........s..DlhlNPhulPSRMsl...................uplhEh.hhuh..sut...........................................................................................................................................................................s......h..t..sss.Fst................................................................hp.........................................t.l.t.l.....................................................................................................................................................................u...hh.s..Gh.oGp...h............h.....................................................................................................................................................................................................................	0	704	1234	1655
+808	PF04560	RNA_pol_Rpb2_7		RNA polymerase Rpb2, domain 7	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  Rpb2 is the second largest subunit of the RNA polymerase.  This domain comprised of the structural domains anchor and clamp [1]. The clamp region (C-terminal) contains a zinc-binding motif [1]. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription [1].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.99	0.72	-3.72	134	7219	2009-01-15 18:05:59	2003-04-07 12:59:11	15	94	6073	138	1845	5823	2697	79.50	52	6.84	CHANGED	GGQRFGEMEVWALEAaGAAasLpEhLTlKSD....DlsGRsphhps...................IscGcsh.css.lPESF+VLl+ELpSLulslclhtp	........GGQRFG.EME.......VWALEAYGAAa.sLQEhLT.l.K.SD......D.V....sGR..s+hYcs.........................................................................Ilc..G...c...s....h.....cs...G..hPESF+..VLl+ELpSLulslcl..p...................................................................................................	0	651	1163	1560
+809	PF03874	RNA_pol_Rpb4		RNA polymerase Rpb4	Finn RD, Bateman A	anon	Finn RD & COG1460	Family	This family includes the Rpb4 protein.  This family also includes C17 (aka CGRP-RCP) is an essential subunit of RNA polymerase III. C17 forms a subcomplex with C25 [5] which is likely to be the counterpart of subcomplex Rpb4/7 in Pol II [4].	21.60	21.60	21.90	22.40	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.49	0.71	-4.09	88	790	2012-10-03 03:05:55	2003-04-07 12:59:11	11	11	467	61	545	755	50	113.00	23	70.54	CHANGED	hLo.sEshplLp.phpppppt...................................................................phsplhp..cslc.Ylp..p......................huchppt-s.........................spplhptLp......php........L.pchEthplsslhPpshsElpsllsphcp....................................ch..........s-...-plpplLchlpchh	..............................................................................................................L...Esh.lLp.phpppppt................................................................................................ttptphs.phhh..colp.Ylp.p......................hu+hp.spEs....................................................................lppl.h.phLp..............php..............L.p..chEh..h......pl.......s...NlpP..po..spEhpsl...ls.ph.ct....................................+..h..........s.-.....-plpplLc.lpp..h......................................	0	176	309	446
+810	PF01351	RNase_HII		Ribonuclease HII	Bateman A	anon	Bateman A	Family	\N	20.60	20.60	21.20	21.00	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.10	0.71	-4.67	14	6064	2012-10-03 01:22:09	2003-04-07 12:59:11	13	19	4789	32	1433	4292	2775	182.20	35	75.83	CHANGED	hGlDEsGRGslhGPlVsAushls.cp.....h.thGlcDSKKLocp+RptLtchIp...................pthhuhtlsh..hpssphsthsltpsshhshhc.tlpph.slpsc..tlhlDu.ps.....Pt.hththps.lht.............uDuths.luAASllAKVpRD.hhh-hhpchsth.shspssGYsoc.+tptlhchssss.......htRhoFtss	......................................................sGlDEsGRGsLsGPVVs..AAV.....l......L........s....s..p..........................................h............G...l....s..DSK+.L..o.c.p.+.R.p..p.LhptIp....................................................................pp....sl...sh..sluh......spsp.c.I.....D..p.......l.....s..I..hp...A.s....h....hA...M....t..........c....A....l.......t.......t.......L........s......h......p......P..c.....................hl..L..l...Du.ph...........................st...h.....s...h......s...t...p...s...l....lc..................................................GDupsh.sIAAASIlAKVsRD..th.......M...h...............c.................h............s..........p.....p...............a..........P............t..........Y...............s...............a.............s...........p......ptGY.s.T.ptHh.pslt..chGsss..........h.HRpSFts.................................................................................................................................................	0	496	923	1217
+811	PF01138	RNase_PH		3' exoribonuclease family, domain 1	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family includes 3'-5' exoribonucleases.  Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction.  The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA.  Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	21.00	21.00	21.10	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.70	0.71	-3.84	192	13598	2012-10-03 01:04:38	2003-04-07 12:59:11	16	86	4722	247	4120	10174	6384	132.80	29	40.48	CHANGED	phRslplch..G...hhppAs...............GSshlphG..................s..TpVlsslpsst...t..............................tt..s..............lslphpht...shussph.......................pp..st....ssccph..........hup....l.......l............ccslcssh..........h...........phh.......hplplshpllss................DG............................................shhssul....suushALhsuslP	........................................................................................hRslslcs..G......hh.t.p..u.c.................GSs.l.h...phG......................-....Tp..l.L.s..s.so..hsp...ts.........................................................................hh.....-.hs........................t...ltscYph.........sausGch...................................................tpt...Gp......................suc+ph..................thuR.......L......l......................................................cR.u.....l..+..slhs....................p..................................................................tth.....hsl.p.ls....s...pl.lp..u.....sG....................................................us.p..h..A.u.l....sG.uolALhsuslP.............................................................................................................................	0	1408	2573	3461
+812	PF03725	RNase_PH_C		3' exoribonuclease family, domain 2	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family includes 3'-5' exoribonucleases.  Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction.  The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA.  Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.01	0.72	-4.04	107	12290	2009-01-15 18:05:59	2003-04-07 12:59:11	10	60	4627	243	3309	8916	5491	69.10	29	20.56	CHANGED	shssuloluhl..s............sp.......hllDPsh.pE-.................htpu...slslsh........ssst..........ph.slhpt........ss....st....lspcplhcslchutps	.................................................sslAuluhGl.l...s.....................................sp.............hlh..Dhph...pE-..............................hu.ts..........Dh-hhV.........AGop................cs.h...sshtt................................stth.......tloc-.hhpALthA+p..................................................	0	1115	2087	2755
+813	PF02755	RPEL		RPEL repeat	Ponting CP	anon	Ponting CP	Family	The RPEL repeat is named after four conserved amino acids it contains. The function of the RPEL repeat is unknown however it might be a DNA binding repeat based on the observation that Swiss:Q9VZY2 contains a Pfam:PF02037 domain that is also implicated in DNA binding.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.67	0.72	-6.75	0.72	-4.50	54	1765	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	175	8	892	1495	0	25.80	41	10.30	CHANGED	cpLp++lspRPsh-ELlc+sILppps	........pLp+KLupRPshcELhc+sIL.tp.....	0	145	243	514
+814	PF04059	RRM_2	rrm_2; 	RNA recognition motif 2	Wood V, Finn RD	anon	Pfam-B_4981 (release 7.3);	Family	\N	21.00	21.00	21.00	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.47	0.72	-3.98	4	387	2012-10-02 20:46:34	2003-04-07 12:59:11	7	16	140	0	313	408	9	92.10	44	16.81	CHANGED	RTTLMIKNIPNKYTppMLlutIDE+sKGTYDFLYLPIDFKNKCNVGYAFINhlpPppIlsFhcAFNGKpW-KFNSEKVAoLuYAcIQGKsALIu+FQ	...........................RTTlMl+N..IPNKaop.p.hLhshl..D.c.........p.....p..............p............G........p.......YDF..h.YLP.ID........F............p..........N.c......C.....NlGYA..FINhhsstthh............tFhp......sFp..........sp+W........p.t..F.s.........S.......c..........K..lsplsYA+lQGp.psLlt+Fp................................	1	154	233	283
+815	PF01137	RTC	RCT; 	RNA 3'-terminal phosphate cyclase	Finn RD, Bateman A	anon	Prosite	Domain	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate [1]. The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids [1]. 	20.60	20.60	20.70	20.80	19.90	20.40	hmmbuild  -o /dev/null --hand HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.31	0.70	-5.57	29	1194	2012-10-02 15:27:11	2003-04-07 12:59:11	16	17	881	19	569	985	32	309.70	31	89.51	CHANGED	lDGShtEGGGQlLRouluLSsloGcPl+I.hsIRAsRsp.PGLppQHLsulcslpclssAplpGhplGSppLhFpP...........uplcGG.shphDl......GTAGSlsLlLQslLPhhhFucpssclplpGGTcsthuPslDal+pVhLslLc+hGhpsc...lcll+RGaYPcGGGcVhhplp........Psp.hs.lphhchupltplpGhuhssplssphupcptcssttthsphh.tshhhttt........................ssusshhhshpppsshhuusulGc+GhsAEtVGccAAppLlcplpsuusVDcahuDpllhahALuss...phpsuclos..HhhTsltllcpF.hshca.clct	.......................................................................pGs.tcGGGQllRpuLsLShloGpPhpI.ppIR........u..s..............R...s...............p...P..............GL.............h..............ppHlosl+hhscl.........s.s.....u..s..l..........u.....s.............phuup.plhFpP....................................Gt.l.p..G......G....php.....ash................so.A..u.ShsLlLpsl.LshhhF..........u................c...................s.......s.................p.....lpl..p.G......G.T....s..s..s.....uP....s.....hDalcpl.hhP.l....L....t.+.....h...G.l...p.tp.................hp.l...h++...G....a............h...P.....t....G....G....G.Vthpls....s.st.t.h.p.slpLh-pGplhphpG.shhssls.phspRthtshts.hthh..shh.hspp................................................................................................................................................................................................tssssss.hthpspshttth.shGpptsssEslutpsspplhc.ltpsusVsc.ahtDplll.MAL........u....s........s..............................u........chp...l........u.......p.........o..........HhhosltllcpF.hsspFt...h........................................................................................................................................................................................................	0	191	322	470
+816	PF05189	RTC_insert		RNA 3'-terminal phosphate cyclase (RTC), insert domain	Finn RD	anon	manual 	Domain	RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of  RNA, in a reaction involving formation of the covalent AMP-cyclase  intermediate [1]. The structure of RTC demonstrates that RTCs are  comprised two domain.  The larger domain contains an insert domain of approximately 100 amino acids [1]. 	20.60	20.60	20.80	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.14	0.72	-4.01	99	1028	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	852	19	465	818	15	100.70	29	28.85	CHANGED	h-pGplp..c....lpGlu..asspl.ssplApR.hcuAcp.hL.....th.h.-lplps..................tpsuh.usGsGlsLhAcspp..shhuusul..................GpcGhsAEcVGccAAppLlcpl.psu	.......................h.-pGplhp..hRG.s............h..s..s.s.V..shpl..AcR.lssstuhh............sh.l.t-hpIps............................hspsp..u..PGsuloLhsE.....ops............h.hhthpsl...................................................Gcctss..AEsVutpsucplhc.ltp.............................	0	153	268	382
+817	PF00301	Rubredoxin	rubredoxin; 	Rubredoxin	Finn RD	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.78	0.72	-4.09	43	2943	2012-10-03 19:45:42	2003-04-07 12:59:11	15	40	1967	86	844	2104	307	46.10	48	23.38	CHANGED	+ahCpl..CGYlYDsspGDstpslsPGT.Fc-LP--WsCP.C..Gss.KcpF	........pa.Cpl..C.G.alYD..s..stG-P..........p...p......s..l..s.PG.T.......a...p....-l.P.-.c.WhCP.C..usu.KssF........	0	288	568	732
+818	PF02759	RUN		RUN domain	Bateman A	anon	[1]	Family	This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases [1].	20.70	20.70	21.00	21.20	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.78	0.71	-4.40	50	1686	2009-01-15 18:05:59	2003-04-07 12:59:11	14	59	103	6	970	1562	5	138.00	21	18.38	CHANGED	sLssslEtlLpHGL+t...........................................................................................................p..thhhtpppshashhpph.................tph.hsssppl...hpplp.plpplpss..........................................................pu+......................t+AWl+hAL.c+hLspalphLhpspp...hl.............s........paYpstAllhsstts......hlhslLsuLss.lsFslshps	..........................................................................................................................................................................................hssslEthltHGL+t...................................................................................................................................................................................................p....hhhh..t.p.pp..shas..hh.pth.................................................tph...hsp.tp.ph............hpp.l......p....sl...pp..l..p..ss....................................................................................................................................................................................hu+.......................................t+Aalp..hu...L...........c..+h....Lspa.l....ph.Lhp..spt.....hh..................................p.........c.aY.c.t.t.Ah....l..h...sppts..........lhshL.hsL.ss.lpashsh..............................................................................................................................................................	1	257	332	591
+819	PF00853	Runt		Runt domain	Bateman A	anon	[1]	Domain	\N	20.50	20.50	21.10	26.40	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.74	0.71	-4.71	6	488	2012-10-03 00:25:27	2003-04-07 12:59:11	14	7	118	24	206	469	0	119.90	74	31.17	CHANGED	ERols-hlsEaPGELV+TuSPsFlCSsLPuHWRSNKTLPlAFKVlALGEVsDGThVTI+AGNDENaCuELRNsTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIoIuTsPPQlATYs+AIKVTVDGPREPRp+ppp	............................Rshs-hlu-Hsu.ELVRTsSPsFLCSlLPoHWRsNKTLPl.AF.K.........VVAL..G..-......VPDGT...l............VTVhAGNDENYsAELRNAoAlMKNQVARFNDLRFVG....RSGR.....GK.S.FTL.TITVh.TsPP.Q.VATYpRAIKVTVDGPREPRp+pp.........................	0	47	63	141
+820	PF00665	rve		Integrase core domain	Bateman A	anon	Pfam-B_10 (release 2.1)	Domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.26	0.71	-4.00	230	47519	2012-10-03 01:22:09	2003-04-07 12:59:11	21	846	4253	244	8847	47451	3435	111.40	27	21.34	CHANGED	psppshphhphDhs...hhp..s.t................................talhshlDshS+hhhshhhppc........ssptshphhpthhtthtsh...............hhlpoDpGspassp...............phpphhpphG..lphphspstsPpssuhsEphpppl+pph	...........................................................................................s..tts.thap.hDhs......hhp.......t......................................th...lh.sh.l.....c...s..h.S...t.h...l....u.......s..l.s.sc...................................sp.p...s..s..h..t.h...L.......c.............l...t...s.p.h.s...............................................sphl.+oD.s.G..s.p.Fsot.........................................th.p.t.h.....t...h.h..t.G......l...p..p......p.h....u........h.s.......h.......s.......P.p...s......p...G.h...sEsh..sppLKp..h...............................................................	0	3423	5434	6849
+821	PF00077	RVP	rvp; 	Retroviral aspartyl protease	Eddy SR	anon	Eddy SR	Domain	Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam:PF00026).	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.29	0.72	-4.09	50	124336	2012-10-02 15:32:34	2003-04-07 12:59:11	15	164	892	1164	420	112085	121	94.30	86	28.21	CHANGED	sh.pcPhlplplsGp.............hpsLLDTGADcollpptphshp......hpsphltGlGGth.pscphpphhlplttcphps.....shllhP..sPls......llGRslLsphsspLs	...............................................T.LWQRP.LVT.IKIGGQ...............LK.E.ALLDTGA.DD.TV.L.....E....E...h......N...L....P....G....+.....................W.K...P....K........M.I....G....G....I.......G...GFI.......K..V....R....Q.......Y.......D....QI........I.E.....I...CG.HKAIG.............TVLV.G..P...TPVN..............I.IGR.NLLTQIGCTLN.....................................................................	0	190	263	349
+822	PF00078	RVT_1	rvt; RVT; 	Reverse transcriptase (RNA-dependent DNA polymerase)	Eddy SR	anon	Published_alignment and HMM_iterative_training	Family	A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.44	0.70	-4.98	152	172360	2012-10-02 12:54:00	2003-04-07 12:59:11	22	1060	4989	405	8257	157991	1195	171.90	64	42.06	CHANGED	l.Kps...........uphR................ph+hlschhtp.............................hp.sphuh.shtsh.................htps.phhhplDlpsuFpplshs.hhp.hhpshshst..........................................................ttphphpslPQGhhhSPhlaphhhpplhp.lpp.........................................................................thhhhtYsDDlllhsps.tpp..........hpphhptltphlpp...hGlpls.cKsphh.......................................tpphcaLGhpl	........................................................................................................................................................................................IKKKD...........STKWRK..L.........................V.D..F.R.E..L.N..K.R.T.Q.D.........................................................................F...W.E...V...Q..L.G..I..PHP.A.GL....................................................................K.KK....KSV...T..V...L.D......V..G..D..A...Y........F.....S........V.....P.....L....D...c.....-....F.........R....K..Y....T...A...........F....T........I...P.........S......h....................................................................................................................................................................................................................................................N....NE.....T....PG....I.......R...YQY.N.....V....LP...Q..G...............W..K...G...S...P...A..I.F....Q....u..S....M.T..K.....I....L..E....P..FR+pN...............................................................................................................................................................................................................................P-I...V..I..Y...Q.YM...DD..L....Y.....V...G....S..DL...EIGQ...................HR.s.K....I..E....E..L.R.p......HL....L+.....W......G....F..o.....T.....P...D.....K....K..HQKE..................................................PPFlWMGYEL..............................................................................................................................................	0	3604	5373	6662
+823	PF03501	S10_plectin		Plectin/S10 domain	Barker W, Wu C, Bateman A	anon	Pfam-B_2138 (release 7.0)	Domain	This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.	22.20	22.20	22.20	23.00	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.25	0.72	-4.13	39	605	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	384	4	306	562	4	93.60	56	26.87	CHANGED	lPKpsRptIYcaLFcEGVlVAKKDhphs.pHs-........l...slsNLpVl+shpSLcSRGaV+EpFuWpaaYahLTsEGIcYLRcaLaLPs-.lVPuTh++pspst	...........hPKpsRhtIYch.LF.+.E.GVhVAKKDhphs...KHP-..........l...slsNLpVlKAhQSL+S+G.Y.VKEpFuWpHaYWaLTNEGI-YLRpYLHLPsE.IVPATL++pt+...............	0	106	165	242
+824	PF01479	S4		S4 domain	Bateman A	anon	Medline:99193178	Domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.81	0.72	-4.53	155	36010	2012-10-01 23:15:27	2003-04-07 12:59:11	20	39	10093	225	6709	24712	7637	47.10	28	18.58	CHANGED	hRLDphl..hchshspopppAcplIppGcVtVNGchls.suhtlp..ss-hl	..................RLDphl.......hch...u..h..s..s....oRspAc.pllpp..G..c.l.t..V..NG....c....h.lp..suhplp..stDhl......................	0	2224	4271	5635
+825	PF04382	SAB		SAB domain	Bateman A	anon	Bateman A	Domain	This presumed domain is found in proteins containing FERM domains Pfam:PF00373.  This domain is found to bind to both spectrin and actin, hence the name SAB (Spectrin and Actin Binding) domain.	20.90	20.90	20.90	20.90	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.27	0.72	-4.27	6	436	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	42	0	117	282	0	48.50	54	6.12	CHANGED	Khc-LDKoQD-llKHQASISELKRoFhEo..sspsRssEWE..KRLST.SPhR	..................hc-LDKsQ--lhKHQASISELKRsFhEo..sspsRssEWE...KRLoT.SPhp.......	0	4	12	42
+826	PF03399	SAC3_GANP		SAC3/GANP/Nin1/mts3/eIF-3 p25 family	Mifsud W, Moxon SJ, Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_2845 (release 6.6) & Pfam-B_4388 (release 7.5)	Family	This large family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins.  The family includes the yeast nuclear export factor Sac3 Swiss:P46674, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localisation of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.  The 26S protease (or 26S proteasome) is responsible for degrading ubiquitin conjugates. It consists of 19S regulatory complexes associated with the ends of 20S proteasomes. The 19S regulatory complex is composed of about 20 different polypeptides and confers ATP-dependence and substrate specificity to the 26S enzyme.  The conserved region occurs at the C-terminal of the Nin1-like regulatory subunit [4,5,6].  This family includes several eukaryotic translation initiation factor 3 subunit 11 (eIF-3 p25) proteins. Eukaryotic initiation factor 3 (eIF3) is a multisubunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits [7].	26.10	26.10	26.20	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.39	0.71	-4.76	105	1100	2012-10-04 14:01:11	2003-04-07 12:59:11	11	24	325	2	789	1485	13	199.20	22	28.32	CHANGED	ppssPppl+shcllhhphphlhtph....................salhsph+uh+pD..lpl...........slplhEhtshhtl.p..............tc...........ltpasp.sht...pLh.hYtp.............................................p.pps-hhuhhLL.hhL.ps.....................s-hppplph.L.............................................tt.h.psthlphslplpphltpus.........................Yp+Faplh......p.................pss.hhstlhc.h.ahsplRhpshpsls+uYpp...........lslphlpphLsh	..............................................................................................................spplR.....s..hL.tshphlht.h..............................t..a.tal.h-ph+ulRpDlshQt...h.s........slplhEtts+htl.p...................t-....................................hpphs.p...s.p.........pL..pt.hYpp..h......................................................................psppsEFtuY...h...lL.h.h.l....p.s.......................s-ht.p..p.ltt.l..............................................stp..hpps..........tlp....h....Alp......lppu.ht..pus.............................at..+aaclh...........p..........................................................................pss.....h....hshlhc..h...ahsph...R..tpulpshp.+uYp.................lslp.ltphLh.............................................................................	0	272	441	657
+827	PF03435	Saccharop_dh		Saccharopine dehydrogenase 	Finn RD	anon	Pfam-B_4166 (release 6.6) & Pfam-B_6325 (Release 7.5)	Family	This family comprised of three structural domains that can not be separated in the linear sequence. In some organisms this enzyme is found as a bifunctional polypeptide with lysine ketoglutarate reductase.  The saccharopine dehydrogenase can also function as a saccharopine reductase.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.07	0.70	-5.49	82	3742	2012-10-10 17:06:42	2003-04-07 12:59:11	13	32	2288	17	1319	4625	2619	321.10	19	76.28	CHANGED	llllGs.GslGpsshthltcphch........plslsspstpphpphhtt.........tshphpshslsssshps.Lssh.lpps...chllslussh..tsh.slhchChcpGstYlD....Tuh.....................hppthhphcpptt.....tuGsTslsssGhsPGlsshhstpulpclt.............................sphtphhulc.hasutt............s.tassoWSscGhlpE.hps........t...sElshtspppph...shhhtsGsshhhah.pcsushspshshhst.....shhhs...slphssahshhp..htshshhc.ssh.hh..................................................................hss.csltulhc.hssht.phpsh.hplh.hhc....Ghtc.Ghhhhtphpps..hspths.hppsppthshssusshtlsutllssshhs....ptGllps-ph.hp.sh...hhshlt...Gl.hs	..................................................................llllGu..G.hlu.p..h.s.s...p.h.....lsp.psph....................cl.s.l.A.....u..R...s.....t...p.+.h..ptl.ht.................................tth.p.h.p...s...h.t..l.....D....s....s....s.....s.....p....s....l...t.....th...lppt...........clV...l...s..ss......s.....Pa.............hsh...slh.cA..C..l..p..s.G.s....c.YlD.........ssh............................................................................h.ph.h..t..h....c..cp.hc......p.uGh.s..hl.us.G....h..D..P........G.hs...sh...hs.t...hhhp.....phh................................................................t..........l..t.....h.......s...uth........................ht.h.sa..s..s.t....h....h.t.........................h.......t....t....t..........t.h..........h..t............h.......................h...........h.h.........p.t....h...........................h..h...........h.........t.h.t.hht...........hht.................................................................................................................................phh..thh............................t............h..h.....h.......................h......s.................................................h.h.s.s....h....hh.......................................th.................................t.........................................................................................................................................................................................................................................................	0	431	806	1113
+828	PF00536	SAM_1	SAM_1;	SAM domain (Sterile alpha motif)	Bateman A	anon	[1],[2]	Domain	It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.98	0.72	-3.80	65	6213	2012-10-02 20:42:54	2003-04-07 12:59:11	25	406	310	71	3366	7526	101	63.10	23	9.07	CHANGED	shhshpsVs-WLcu...l.th....spYtcpF.psshhshctlhplot-D..Lhp.lGlshhGHp++Ihpulptl+	.........................h...t.tpVspW.Lp.s...........l...sh.........sp.Yt..p.tF..p........p.....p......h......h...s.......s..c......t.....l..h.....p...l.o..p..p-.................Lp...p..lu.....l.p.t.....Gcpt+lhtulpth.............................	1	782	1136	2102
+829	PF02198	SAM_PNT		Sterile alpha motif (SAM)/Pointed domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.87	0.72	-4.22	15	1002	2012-10-02 20:42:54	2003-04-07 12:59:11	11	15	115	23	513	1149	0	82.10	32	19.96	CHANGED	hsuappppp+ltlst.....cPphWocscVhpWLpWuhcE..FsLsslshspF.pMsG+pLCsLs+E-FhptsP...hsGDlLapHLphLpcps	.....................................phtppphhlst......-P....ph....WoppcVtpWL.p.Ws.hcE....as..L.t..s.l.s..h..p..p..F...shsGctLCtho+--Fhph.s..P.......hsG..-..l..L..appLphlppt.s............................	0	109	148	306
+830	PF01342	SAND		SAND domain	Christensen J, Bateman A	anon	[1]	Family	The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerisation [2]. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri.  This region of RegA is known as the VARL domain [3].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.68	0.72	-4.27	27	491	2009-09-11 01:11:04	2003-04-07 12:59:11	16	30	96	4	249	486	2	78.20	33	13.91	CHANGED	scs.sh....sstlPVsCGpspGhLhhc+h.ptGhpt+CI............................phc...spahTPpEFphhu.G+upuKcWKpuIRh......sGhsL+pLh-cthLs	.........................t....sh...p..hPlsCGps.puhLhhp+h..ps..GhpsKCI............................php......spahoPpEFEt.hu.G+.ussKsWKpuIRh.....................sGhsL..p.plhcps.L.....................	0	51	98	148
+831	PF02037	SAP		SAP domain	Bateman A	anon	[1]	Family	The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.04	0.72	-7.33	0.72	-4.37	182	2887	2012-10-03 03:04:30	2003-04-07 12:59:11	22	173	629	14	1622	2724	591	34.30	34	5.81	CHANGED	hsphpVs-L+phLcppuLsssGp..KspLlpRLpphh	...........pphpVs-L+ptLcp+uL.s..ss..Gp..KspLlcRLpph.............	0	558	853	1248
+832	PF05184	SapB_1		Saposin-like type B, region 1	Finn RD	anon	Manual	Domain	\N	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.81	0.72	-4.05	161	1396	2009-01-15 18:05:59	2003-04-07 12:59:11	10	105	174	31	654	1402	4	38.80	27	19.67	CHANGED	sshCshCphhlphlpphl.p.sspopppIhphlcp.hC.shlP	..s.shCphCchlVshlpphL.c.sspTcpcIhphlcc.hC.shLP.....	0	247	355	514
+833	PF03489	SapB_2	Surfactant_B;	Saposin-like type B, region 2	Finn RD	anon	Manual	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.44	0.72	-3.89	103	1536	2009-01-15 18:05:59	2003-04-07 12:59:11	12	112	171	39	716	1502	4	34.80	28	17.26	CHANGED	sppCpplVppYtshllphlhpphs..PpplCp.tlslC	..........ppCcphVspYtshllphlhpp.....hs...PpplCs.tlslC......	0	242	367	546
+834	PF04499	SAPS		SIT4 phosphatase-associated protein	Mifsud W	anon	Pfam-B_2011 (release 7.5)	Family	This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.	24.90	24.90	24.90	24.90	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	475	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.59	0.70	-5.85	51	896	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	267	0	509	895	0	267.70	20	48.43	CHANGED	.ppLlspKspphlsF.l+ppcslVcphLpHI-ssslMDhLL+lIS...s-+....s-sspGll-hLpp.....QcLIs+LlshL...........................................s.schsts.hQosAuDhLKAlIolSu.Nss.p...pssIGP.................NpLoRpLsStphlcpLl.shML..............................................................................................................ps.usuLssuVuIlIElI......RKN............NSDYD...................................hshtspsP.os+D...............................................PlYLGp........lL+hFup+lscFhpLlhps..................ptt.lposhGs.hcPLGFcRFKlsELlAELLHCSNMsLhNp.t..thht.RD..R.t...t...ht...tp........t.t....p.......................t.........................................................................................................................................t........t.t..............t...t............................................................................................................................pPs.................lGDhlKlpLh-spllssILchFF+aPWNNFLHNVVaDllQQlhNGshc....................................huaNphLshcLF..................................cpsplsptIlcutcpspch.ppp..............thRhGYMGHLTLIAEEVVKFsphhss..phlo....hlhc..tlpspcWptalppsLs-.TRc.p.ss	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...............................................................................................................................................................................	0	148	248	376
+835	PF04000	Sas10_Utp3		Sas10/Utp3/C1D family	Bateman A, Wood V	anon	Pfam-B_6555 (release 7.3)	Family	This family contains Utp3 and LCP5 which are components of the U3 ribonucleoprotein complex [2][4]. It also includes the human C1D protein and Saccharomyces cerevisiae YHR081W (rrp47), an exosome-associated protein required for the 3' processing of stable RNAs [3], and Sas10 which has been identified as a regulator of chromatin silencing [1]. This family also includes the human protein Neuroguidin an initiation factor 4E (eIF4E) binding protein [6].	20.50	20.50	20.60	20.60	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.78	0.72	-3.79	122	865	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	313	0	604	854	4	85.50	20	23.39	CHANGED	hlpslspslsplpspl..ptlhpth..................httths.................lhphKhphhhuYhtslsha........hhL+hp.shsspp............................HslhpcLhcl+phhc+	..........................................................................................lpphppplsplpstl...pslhpts...............................ttthss.......................h.hcsKhpllluYhhslsaa..........hhL+sp..uhssps............................HPlh.p.cLhclRphhc+...........................................	1	186	316	487
+836	PF01547	SBP_bac_1	SBP_bacterial_1; 	Bacterial extracellular solute-binding protein	Bateman A, Griffiths-Jones SR	anon	Pfam-B_269 (release 4.0)	Family	This family also includes the bacterial extracellular solute-binding protein family POTD/POTF.	20.50	15.00	20.50	15.00	20.40	14.90	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.87	0.70	-4.70	129	9759	2012-10-03 15:33:52	2003-04-07 12:59:11	20	37	2534	267	2818	28939	7759	292.70	15	65.96	CHANGED	ssshpp...shpthh.pp....a....pc..pss..lcVp..hp.s...sssshtp.....h.hthtsus...ss.Dlhhs........h.....hhpt..shhtslsshhtst.hh.h...........hh...h.............................shha.........ppphht............................sWs.-hhphstphttpstsh........................hhh.h.tthhhhh..h....s............................................shthh.thh.......thtshtshstshstshshht...........pGpsshhhsh.ht..........h......................thhtsttpst.phshh.....................sshs.hslspsupp....tct....AppFl........pahhss........................pspt	..........................................................................................................................................................................................................................tttt..........htphh..pt.............F.........pc....p..s.s......lc.lp..........hp.hh..........s....s...s..htp..................cl..p.s.th..s.u.Gs....................sP...D.lhhh...........sssths.............phspp...........Gh.l..h..s...l...s...s....h...h..sp.........t.....t........................................................................h......t...h.hp.....pht.........................tpha..ul....P............h..........t....s......s....t...........s........l..a..Y................................s.+c.lhc.................................chG.lp.................................................Pp...Ta......-......-....h....h...p....s....s.....c.....p....l....p....p...ts.hss......................................hhh...t.t...t...h.....t.....t..t....h....h.....h...h.............h...h...t...s.hG.........s....t.h..h..s.t.pht.....................................................sh.sss.thhp..............shph....htp..h..h........................................t.........t.....h....h......s..............s....s.....t....s......h......s...h...s....p....s....h....s..h.ht.......................................sGc..s..u...h...h..h.......s..s...h.....h........................................................................................................................h.t...t..t..t.t..t..........t...t....p....h..s..h.....h..sh...P.t....h.t.sst.t...........................hss.s..h..s..l....s....p....s...o..c..p...............ct............Ah.c.al................pahhs.t..............................................................................................................................................................................................................	0	1094	1940	2361
+837	PF00497	SBP_bac_3		Bacterial extracellular solute-binding proteins, family 3	Finn RD	anon	Prosite	Domain	\N	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null --hand HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.47	0.70	-5.10	483	31454	2012-10-03 15:33:52	2003-04-07 12:59:11	15	351	4322	113	7607	27422	5780	223.60	19	63.80	CHANGED	lpl.usss.shs.Pasahct............sGphsGa-lD....lhpt....luc.ch.Gh....c.hchh......h...sasshl.s.uLpsG.c.h.Dh.lhuuhsh......Ts-R..p..c.p...........ls.F.op.P..Yhts.stsllsp..p.....s.....................................................................................................................ph...p...t.........-L...pG....................+..p.....lu.ltpG.os....tpth...htp.......h................thpl....................h.....h.sshsps.ht........s.LpsG...clDAhls-tsshthhhpppsttthhh......................ttshtspthuhshpcssspLhptlspultpl.ppsGphp.....c.l.hp...Ka.hst	....................................................................................................................................................................................................................................................lhlu.h.ps..s..h.s..P.a...p...h...hst.................ss..p...h..h...G.h..-.lD................ls....p.t........l....sc....ph...sh.....................c..hp...hh....................h..sa.s....s...hl.....s....s.L.....p.....s........s.....c........h......D...h....l.....h......u.....s......h....o....h................T....s....c...R.......p...c...p....................................hs....F....os......s......Y....h......p......s......s.....h.......t......l.l.spp...s....................................................................................................................................................................................................................................................................................................t..sl...p.....sh.t............-..L........pG...........................c....p.......l.u.....s..t...p...G...os.................tp.p.h........lpp...........h.........................shp.l........................................................h.....p...h....s...s....h...s...ps...hp...................s....L....p....s...G......+...l...D.....u.h......h...s.....D....p....s....s....h....t...t....h...h..pp.p.s.ththhh................................ttthtsps....h...u...h......s......h.....p.......+.....s...........s.......s.......p.......L....h...p....t...l...sp...sl.t.p.....h...p.....p.....s.....G......p......h..p......p...l...p+a.h..t..........................................................................................................................................................................................................................................................................................................................	0	1937	3962	5901
+838	PF04144	SCAMP		SCAMP family	Bateman A	anon	Pfam-B_1298 (release 7.3)	Family	In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain proteins to the N-terminal NPF repeats but may have additional functions mediated by their other sequences [1].	23.20	23.20	23.30	24.00	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.13	0.71	-4.39	39	634	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	162	0	330	557	0	161.50	37	57.61	CHANGED	cpsNWP.Ph.t.h.htPhhYpDIssEIPs.caQ+hsphhahlWhhh............shsLhhNlluslshahts..ss...ussFuLullahllhsPsualsWYRPlY+AaR......................oDSuFsFhhFFhhahhplshslhtulGhPsh......GhsGaIsulshhps.shs..lulhhhlsshhFslpuslulhhlp+VaphaRtoG	.......................psNWP.Ph............htPhhap.DhssEIP....ch..Q..+hsphhYhhWhhh..........................slsLhhNll.usl.uha.hts.............su.....sssF......sLulla....h......l........lh..s.Psoal.sWYRPlY+AFR.......................................oDSuhpFhhFFh...hahhphshplltAlG.hs.....sh........................G.h..sGhlsu.l...sh..............hsp.....shs.....lulhh.h.lsshhFshtul.hu.......hhhlp....cVathaRtsG.....................................................	0	89	145	226
+839	PF02023	SCAN		SCAN domain	Bateman A	anon	Pfam-B_1614 (Release 5.0)	Family	The SCAN domain [1] (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several Pfam:PF00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerisation [2].	20.20	20.20	20.30	20.40	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.10	0.72	-4.51	62	2273	2009-01-15 18:05:59	2003-04-07 12:59:11	12	322	50	7	1114	1819	0	93.00	48	19.04	CHANGED	.ssEshRp+FRpFpYp-...ssGP+EALupLpELCppWLRP.EhHoKEQILELLVLEQFLoILPtElQsWVppppPcSuEEAVsLlE-Lpcphpcs.t..pts	....................st.EshRp+FRpF.pYpE.....ssGP+E.ALup.....LpELCppW.LR..P..Eh..+.TK.EQIL.E.LLV.....LEQFL..oILPtElQsWVpp.pp..Pc.SuEEAVsLlEcLppphpp.....h...............................	0	119	159	371
+840	PF02404	SCF		Stem cell factor	Mian N, Bateman A	anon	Pfam-B_2598 (release 5.4)	Family	Stem cell factor (SCF) is a homodimer involved in hematopoiesis. SCF binds to and activates the SCF receptor (SCFR), a receptor tyrosine kinase. The crystal structure of human SCF has been resolved and a potential receptor-binding site identified [1]. 	20.00	20.00	20.50	20.90	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.77	0.70	-5.20	4	137	2012-10-02 01:28:15	2003-04-07 12:59:11	10	3	70	16	36	126	3	171.70	49	93.19	CHANGED	MKKsQTWIITChhLQLLLhNPLVKTQu.CtNPVTDDVpDIsKLVuNLPNDYhITLKYVPtMDsLPsHCWL+.MVschShSLpsLLpKFSsIS-h...LSNYSIIspLs+IlsDLhACht.cpsKs.lKEsu+h.EpcpFhPEpFFplFNRoI-saK-.Fhsu.DpsDClh.Sos.TPEpDSRVuVTKsh.hPPVAASSLRNDS......SsSN+cAhs.IpsSSLQhhulALsuLlSLlIGFhhGAlYWKKppP.ShscosEsIQhp..pE-NEISMLQQKE+Ea.pV	.........................h....hhh.......tt..hN.lTsslpclshLhtNlPpDYhIslpYlst...lsshCWl...V.php.SLpsLhpKFsphSp......NhsIh.ph...h...............h.t..t.....t.h.stpaFthh..p.....hpt...s...s.cpu-Clh...sos.sPEp-scs.shopsh.hs..h..................................................................................................................................................................................................................................	0	2	5	15
+841	PF00188	CAP	SCP;	Cysteine-rich secretory protein family	Finn RD. Yeats C	anon	Yeats C	Domain	This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes [2] and non-vertebrate eukaryotes [3], The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins.  Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences [4]. The Ca++-chelating function [3] would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how Swiss:Q91055 blocks the Ca++ transporting ryanodine receptors.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.57	0.71	-3.63	98	6534	2009-01-15 18:05:59	2003-04-07 12:59:11	21	194	2233	38	2946	5991	336	123.50	18	43.36	CHANGED	lshhNphR.....t......................stshhs.Ls...asss.LsphApppupphsp...........................tt.htpshspshthhthsst......t....................spshhtttpphptt..............htshh........sss..........sHhpplltssssplGsuhspssstt...............hhhlsta	......................................................................................................................................phhNthR....................................................stpt...hs.lp..........assp.LsphAp..t..a.u.p....ph.st............................................ps..hsp...s...t....s...p..s....h.t.....h.htt.hpt.....hsh..h........................................spshh.s.pt.pshshs....................................h.p.s.hh................ss.s....................GHh..s...p..ll.............s......s......h....s..plGsu....h....shsspt....................hhhsp.a......................................................	0	1119	1733	2458
+842	PF03803	Scramblase		Scramblase 	Finn RD	anon	Pfam-B_3893 (release 7.0)	Family	Scramblase is palmitoylated and contains a potential protein kinase C phosphorylation site.  Scramblase exhibits Ca2+-activated phospholipid scrambling activity in vitro. There are also possible SH3 and WW binding motifs. Scramblase is involved in the redistribution of phospholipids after cell activation or injury [1].	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.44	0.70	-5.26	10	783	2012-10-02 20:44:47	2003-04-07 12:59:11	10	15	285	0	512	771	22	198.70	28	69.98	CHANGED	Mousht.hsssPsuL-hLsphDsllVpQplEhlElhTGFETsNRYsl+sstGpplhhshEc.....SsshsRQhhGscRPFshclhDshGpEVhplpRPFpCss...p.....hssshppt-l....ps.sGssIGhVtQpWchhcspaclhsucp.psshplpuPssshs.sssspsF.V+oh-s.pllGpIsRpWsGlhREhFTDADsasl+FPh...........................DLslchKAVlluusFLIDFsYFEc	...............................................................................................................thp.hL.t.h.stlhlp.pp..h.E....hhp....................h....h.....h.....s..h..E..psN+Ytl.........h.......s.........s.............G.......p........t...l...h.h.....s.....hEc...................sshhsRp.h.h..t.....s.t.R......s...F......p..h..cl...............h......D.....s........h...........s....p...........c.........l......h.p..hp.R....P....hp..h.s......p....................................h.s.h..hpph.pl...................ps.s.s.Gph.......l..G..hlt...Q.....p..a....p.............h.....h................p..a....s.l.s......tpt...pp.............h........h............p...............l.......................G..........P..........h........h..h.........h..........s.....s...............h....ts....h.............s....F............pl.....hs...h.........s......t..p.............l......GpI.s....+....p....W.s..G.......h...h...p..-.h......h....T-..ss....pas..lp.F.sh...................................................................................................................sL..s.l..c.....+AlhluushhIDh.aFp............................................	0	214	284	400
+843	PF01390	SEA		SEA domain	Ponting C	anon	[1]	Family	Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain [4].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-10.06	0.72	-4.36	94	1758	2009-01-15 18:05:59	2003-04-07 12:59:11	15	244	103	4	1017	1679	0	104.30	16	14.60	CHANGED	sstthhphshpl.sshp.....asschpsssStpapslspplpptl...pphapps......ttahpsplhsh.........................pp........Go...llsphhlha.ptssststtshtptltpthpp....tthhslthssp	................................h.....hthsh.pl.sshp........aspchtsssStpa...ps...h...ppp...lp.phl....pp.hapss.........stat..ssplhsh................................ps.....................uu.....lhVphhhha..p.s.s.s.t.s...h..tt..h.p..h..p...t................h.......................................................................	0	253	329	554
+844	PF04091	Sec15		Exocyst complex subunit Sec15-like 	Wood V, Finn RD	anon	Pfam-B_7871 (release 7.3);	Family	\N	22.40	22.40	22.40	22.50	21.80	22.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-5.10	31	418	2012-10-03 17:31:52	2003-04-07 12:59:11	7	15	255	1	266	408	1	281.90	32	39.47	CHANGED	-Y-p.Vlphpahp........sptts.s...FPhhhPFSphhP.sCh.l+..........palsphhtFhsphhp.p.spls-.hl++shDpLLsch....lscslhphlpss....shpQlsQIllNLpaaEhAspplpphlsptptssps.ss...sph....tLpupcpapss++tAEpplhphlsoKID-hl.-hs-YD.Whs.spsss.-........sstalp-lspaLcshhsSshhsLPtplpphlhhcuhcHloppllsl.lLsssl+plsspultshshDlpaLEpFsspl......................................p......sssLppsFsEL+QplsLlhossh-.-a..........h-sshRt++YsRl.cspsuhhlL-Khp	....................................................Ych.lht...hp...........p.ph...pp.s.......FPthhPFSphhPthhh..p.l+.....................pFl.thhpFsps..hhh....p.splc-.hl+KuhshLLocp....lspsL.phlppt.....hsLspllQIllNhsahEpACp.L-phlsphp.sh.tp.ss..........tth..............................pLhut.ptF.+.ss...+.c.sAEppIh...phl.spKID-hl..ph...s-Y.D.Whs...scs..ss...c.................sSsYl...-lltaLcshh.ss.hptLP.t..........cltptshhsAhpHlusplh.....................ph.l..L.ss.....-.............l+plshsAltphslDlh.h..EtFsss.............................................p.......tspLp.shh-LRQhlsLhhs....shp.pa..........h-..u..p..p..+Y.+l.ss.pshhlLEKh...................................	0	77	136	208
+845	PF04815	Sec23_helical		Sec23/Sec24 helical domain	Bateman A	anon	Pfam-B_3055 (release 7.3)	Domain	COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.	27.80	27.80	28.00	27.80	27.60	27.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.03	0.72	-4.59	121	1420	2009-01-15 18:05:59	2003-04-07 12:59:11	10	28	326	24	936	1370	10	102.20	26	11.83	CHANGED	Q-Ahsshhu+pulp+shs....ss.....hp-........s+chLsppllclhspY+..phhtssssu.............lhLsp..shchhPhahhsLhKsthl.ps...tssssDcRsahhphlhshslpphlhhl	.....................................-Ahsslhu+h..Al.t+s.s.........ss......h.t-........................spc.hLsppllclhspat.......cht...tssssu.............................hhLsp....shplhPh...ahhsLh+o.phl.ps......h.......s.......s.......ssD-puahhphltp.slsp.hhhl.......................................	0	285	492	755
+846	PF04811	Sec23_trunk		Sec23/Sec24 trunk domain	Bateman A	anon	Bateman A	Domain	COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.	21.20	21.20	21.20	22.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.23	0.70	-5.01	22	1546	2012-10-10 16:07:06	2003-04-07 12:59:11	10	35	327	24	1024	1513	23	236.50	26	28.15	CHANGED	P.PslFlFllDlohs...su.LpslppulhpsL.shLP........spshVGhITasshl+hapls.sh.......ptsp.hsssclp-hh.......................hPhs.sphLlslpcschslpsLLcplsp.hasss..+csppshGsALpsAhtlLpss...sGG+lhlFtuu.sohGs.uhlpsc..cp...shhshcK-ttphhppsstaYcsLApcssspGhslDlFhhs.s.sslAplpslsphTGGplhhhsuFs.......sshFppshpRhh	............................................................................................................PshalFllDs.s..hp..........ps.lp..........slpps.lhts.L.....shLP.....................................sps.....hlGhlTa.s....ph..l.......ph.a...p..lttsh........................................................ptsp..h....s...s..s.p...l...p.-.h.h.............................................................................hPhs...sp.h.L..l..s.l..p..c..s..c.......................................l.ps....l.Lp...p...L.................p....ha..s..s..s.............................p........c..s........t........p..s......hG...sA.......LpsAhtl.lp..............................sG.G..+lh.....l............Ft..uu..............soh.Gs......s...h..lpsc..cp........................shhsh.s..+..-....................t.................t......h..h.......p..p..s.s...........t...aYc.pl.Atcssp...............p...............sh.......slD.lF.....hh.....s..........p...........ss..........l..................u..p..h................ts..............l.sphTGGphhhhssFp.............s..phhtpshp+................................................................	0	340	560	837
+847	PF04136	Sec34		Sec34-like family 	Wood V, Finn RD	anon	Pfam-B_16464 (release 7.3);	Family	Sec34 and Sec35 form a sub-complex, in a seven protein complex that  includes Dor1 (Pfam:PF04124).  This complex is thought to be  important for tether vesicles to the Golgi [1].	25.00	25.00	25.10	25.70	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.88	0.71	-4.53	3	293	2012-10-03 12:17:00	2003-04-07 12:59:11	10	9	255	0	211	309	1	151.10	29	19.38	CHANGED	cscch+cYLQsFpp...pCDpILsQlNuAhp+LtSLp-cY-FVSpKTSsLsEACEQLlcEQpRLsELA-sIQ++LoYFupLEpLNp+LpSPTLSVA.S-uF+EpLsKLD-CIsYIEENPcFKDuPtYLlKYKQCLSKAhcLhKsYslslIpQsT-QlLKcc	................................................h....h.p.Lpth...pp...ph-...t...l..Lsp.....sssslptLpsLpppaptVsscTsshpctC-pLLp-Q...pcLtclu-pIpppLpYFspL-slsp+L.s........u.........P..s...h..........u....V..s...scs.F..h.s.h.Lp+LD-Clsalp..s..H..........P..p......aK-ussYhh+a+phLo+AlpLl+sahsssLpph.spth....t.....................	0	71	115	174
+848	PF02889	Sec63		Sec63 Brl domain	Bateman A	anon	Ponting CP	Family	This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons [2].	33.60	33.60	33.60	34.00	32.60	33.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.13	0.70	-5.21	133	1940	2009-09-17 06:06:13	2003-04-07 12:59:11	11	53	348	4	1383	1943	35	302.80	21	32.16	CHANGED	sppLGcI....ASpYY..........lpapohphasp.....lps..pt.s.tc...........ll......pllotusEFc.....pl.lRppEcppLpcLh...pp.....hs....h.h.................p.tshpssps.....KsslLLQAalSR......h.plp...hsLhs................Dhthlhpsus.RlhcAhh-l.h.....hpcs........ahpsshtslpLsphlpp...............phW.s..pp........sPL.+Qhs.........................thsppl....lc....plcp...ps.h..ohpclh....ch........ssp-ls.......pllp...........p.upplhphlp...pa.Pplcl.psplpshscs..l.............................lplplplpsph.hp...................................th.st............t-saalhlt..D.scspplhthcphtl.....pp.............................tt.h....................lphslPhs.ss.......ph.hlhllSDp.alss.-pphslsh	.................................................................................hthGhl....suhYY..............lpapT.h...pha.p..........lps......ph...s.tc..................................llpllu.tus.EFc..............................p.l....l....R...p..p.E..c.....l.p.pLh.......pp......l.......h.h.....................................................ptph.p.s.s.ps........KsplL.LQ..........AaloR........h..pls.........hsLh..s..............................Dtt.hl...hp.puh.Rll..........p...Ahh-l..s..........................hpps..................ahpss..htshpLsphltp...................thW..s....pp..................ssL...pQls...................................................................................p.h.s.t.p..h..........lp..........phpp......................ts...h.......sltclh........ch..................psp.cht......................pllp..s...............p.hpplhphhp.......ph..P.p.lpl..ph..p...h.p..s.h.spp...h..............................................lplplplp.ph....pp.......................................................................................................................................................hh.tt..............t.csaa..l.hlt.............-.sps..ppl......h.t....h....chh.h............p........................................tth..............................................................................................................................hph....hP....t....................ph..hlhhhsDp.ahuh.-t.h.h....................................................................................................................................................................................................	0	481	779	1155
+849	PF04048	Sec8_exocyst		Sec8 exocyst complex component specific domain	Wood V, Finn RD	anon	Pfam-B_9576 (release 7.3);	Domain	\N	25.50	25.50	25.50	26.20	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.55	0.71	-4.55	22	297	2012-10-03 17:31:52	2003-04-07 12:59:11	9	8	250	0	211	305	0	126.60	26	13.09	CHANGED	pLppllsplphpWsthhpcsssPlplALphhD-oSlGhu+cht-FpphpcphppsLppVVs-HapsFNsuIuoYpplhsslpsSppcltplKptLppupptl.pscpspLpcLspsShcapchIplLstIc-lpplPs+l-ph	.......................................p..........................................D..p..s...s...s.ptpchtc....hpcthcphppsLcplVspHapshssuItoappIpppls................sSpp+lcpl...KpsLtpsKthL..ps........++.............s.............-L+cLhhcuhp......accllplLcpIE....plpplPp+lEt...............................	0	73	119	178
+850	PF00856	SET		SET domain	Bateman A, Huang S	anon	[1]	Family	SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) [2].  A subset of SET domains have been called PR domains.  These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction [3].  The SET domain consists of two regions known as SET-N and SET-C.  SET-C forms an unusual and conserved knot-like structure of probably functional importance.  Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure [5].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null --hand HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.85	0.71	-3.93	267	8450	2009-01-15 18:05:59	2003-04-07 12:59:11	23	382	879	153	5532	8290	1539	133.10	21	17.69	CHANGED	GhGlhApcsItpGp..hlh....phtupl..lstppspppttt.............................................................................................................................................................................................................................................tthh................................................................................................................hhhthtpththsstthsshucalNH...............SC.....................Nsthphh.................................tttplhlhAh+sIpsGEElshsYs	...............................................................................................................................................................................................................................................................................................................................................................hGlh.s.h...p......l...t...sp....hlh..........hs...h......ht.t.h.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................t.............p....t......h......h........h.....c......u....t........t....h....s.....s....h...u....c.......a..l....N..H.........................SC....pP............................N.st.hphh................................................................................tthpl.hl..h..A....h.....+...s.........I.....p..s.GE.ElshsY.......................................................................................................................................................................	0	1814	2953	4471
+851	PF03749	SfsA		Sugar fermentation stimulation protein	Bateman A	anon	COG1489	Family	This family contains Sugar fermentation stimulation proteins. Which is probably a regulatory factor involved in maltose metabolism. SfsA has been shown to bind DNA [2] and it contains a helix-turn-helix motif that probably binds DNA at its C-terminus.	25.00	25.00	29.70	26.60	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.26	0.70	-4.88	13	1762	2012-10-11 20:44:43	2003-04-07 12:59:11	8	9	1701	0	410	1213	1569	211.30	41	87.65	CHANGED	l+RhpRFlu-lpl-.GchhpsHhsNTGphptlhpsGspValp+u-sspRKhsashthspts..sphVslsTthsNcLstcAl..sttlspLs..astlctEVcaGppp...lDFLLspst..thaVEVKusTLscsslA.....hFPDAsTsRGpKHL+ELtpls+cG.aRullLFllh+sshcsFpPspclDPcauchlpcAhpsG.Vcllsapsphshp..lchsphlt	..................................lpRYKRFL..ADV....h.h.......s......s.......G...............c.....t...lThHCsNTGuMpGsh.p..PG.ss..Va.hS...p...S..-...s....s.K.....R...Khs.aohEls....ps......p...................G....t.....hlslN..Tt.hsNpLscEAlt...s..............t..p..............I..s........p........Ls..uY..s.......pl+pEV+..Y..G.....p...p+.......RID..F.h.....L.............p.....s...s.........s...............p......c....s....Y.lEVK......u......VT..L........t...c.....p.....t..h.u..................hFP........DA........lTpRGpKHL+ELh...shst..p........G.........p............RAlll..FsV.+ss.lpp.FsPuc.clDspY...AphLpcAt.ppG.VElLAYpsclospt.htltp...............................	0	139	263	348
+852	PF05002	SGS		SGS domain 	Finn RD	anon	Manual	Domain	This domain was thought to be unique to the SGT1-like proteins [1], but is also found in calcyclin binding proteins.	21.90	21.90	24.50	22.70	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.97	0.72	-4.23	48	564	2009-01-15 18:05:59	2003-04-07 12:59:11	10	29	330	3	345	531	2	76.50	36	24.80	CHANGED	spsWspLs..............h...pscc--cssp.t....................lsshF+plYpsuD-Ds+RAMhKSahESsGTsLoTsWt-lttt.h.....spsPcGhEhKca	.................................................t.psWDpLst...................hpc....p.p.pc-.ct-s..ssu................................LsphF+clYpcuD--h+RAMsKSahESsGTsLSTsWp-Vtptphp.....t..sPp....................	0	113	182	275
+853	PF03983	SHD1		SLA1 homology domain 1, SHD1 	Finn RD, Wood V	anon	Pfam-B_ (release 7.2)	Domain	NPFXD peptides specifically interact with the SHD1 domain. NPFXD is a clathrin-facilitated endocytic targeting signal. NPFXD was originally discovered in the cytoplasmic  domain of the furin-like protease Kex2p [1]. Sla1 is thought to function as an endocytic adaptor [1].  	21.20	21.20	21.70	21.90	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.21	0.72	-4.32	18	166	2009-01-15 18:05:59	2003-04-07 12:59:11	7	29	137	1	116	180	15	68.70	47	6.66	CHANGED	ossKScP-PpKlRoWoDRSGoFKVEApFLGhtDGKIHLHKsNGVKIAVsssKMSh-DLEYVE+lTGpSL-	........t..tcshPsst+sRpWoDRoGoFpVEApFlG.l.p.-GKl+LHK.h.NG.VKI.AVPlsKhSh-DL-YVE+lTG.SL-..............	0	44	72	103
+854	PF04925	SHQ1		SHQ1 protein	Wood V, Bateman A	anon	Pfam-B_11411 (release 7.6)	Family	S. cerevisiae SHQ1 protein is required for SnoRNAs of the box H/ACA Quantitative accumulation (unpublished).	20.80	20.80	21.00	21.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.08	0.71	-4.85	27	208	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	176	5	136	213	1	179.00	31	36.24	CHANGED	Lp...h.ppptp...............lpFocEEpcpht.plsp+paL.ls..p....tplhhsllslLaAYsYD.pps-G-pssE.SuWTIuKLoPplSaLDs.....................hssl+ssllsshRRuLsYPLaRsasLsp+sap-shhhLpu..GKphll+sLLcl+clF.p.hp-hhYlhsclalsDhhsWl..pss.s-phlpsLApclcpth..lscpp.......lp	...................................................................hpFoc-.Epp.ht.plsp+paL..ls..............pt..tppplhhsLl-lLhAYsY-hR.sspG-.pssE...SuWols.KLSssluah-p.......................hsslccslluhhRRsLsY.P.L..aRp...a...pLshpsh.pDshplLph...G..Kphll+sLL-l+clF..p..pp-........stYlhN...clalsDhshWl..pps.ppphlttLupplcph...lpKtt..s...................	1	53	77	115
+855	PF01549	ShK	DUF18;ShTK; 	ShK domain-like	Bashton M, Bateman A	anon	Pfam-B_662 (release 4.0)	Domain	This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges.  The domain is found in the potassium channel inhibitor ShK in sea anemone [1][2].	20.90	4.80	20.90	4.80	20.80	4.70	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.66	0.72	-3.59	157	2278	2012-10-02 17:51:16	2003-04-07 12:59:11	19	119	113	2	2009	2028	124	36.40	29	22.98	CHANGED	sCh....D.p......ssCsthssh....Cp...ss.....shhppp.CspTCs.hC	..................................Ch.......Dtt.......ssCst.h...sp.........Cp..............ss.............shh......p......p......p...CspoCs.hC...............	0	920	1083	1978
+856	PF04542	Sigma70_r2	sigma70_r2; 	Sigma-70 region 2 	Finn RD	anon	manual 	Domain	Region 2 of sigma-70 is the most conserved region of the entire protein.  All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant.  The core binding helix, interacts with the  clamp domain of the largest polymerase subunit, beta prime [1,2]. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation [1,2]. 	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.24	0.72	-4.37	259	39743	2012-10-04 14:01:11	2003-04-07 12:59:11	9	171	5036	49	11330	31962	8852	69.50	22	26.33	CHANGED	lhpph...hthl...hphutch....hsss....h.ss-D..LlQ-uhlthhcu.hcpac.ppu.p..hpsahhthhc....pthhc.....tlRc.pptt	.............................................hpth.hphl.....hp.h.u.t.+h.............hsss...............h..p...h..c..D....ll.Q-.shltl....h....c.......u....h.........c.......p.....a........c...............p.....p.....u................p........hpsah...hthhc....sthhc......tl+c.pt...................................	0	4421	8178	10016
+857	PF04545	Sigma70_r4	sigma70_r4;	Sigma-70, region 4	Finn RD	anon	Manual	Domain	Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1]. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.05	0.72	-4.65	130	17028	2012-10-04 14:01:11	2003-04-07 12:59:11	11	79	4776	54	4045	30085	7549	51.60	33	15.50	CHANGED	sLspLspRE+pllphRa....tpshTLpElGpthulocpRV+QlcpcAlp+LRp	.............................hLppLscR.Ec.pll...p...hRah.......................tpstT.LcEluc....p.h..s......l.oc.pRl+Qlcpc..Alc+LRp.....................	0	1461	2782	3486
+858	PF03145	Sina		Seven in absentia protein family	Mifsud W	anon	Pfam-B_1854 (release 6.5)	Family	The seven in absentia (sina) gene was first identified in Drosophila. The Drosophila Sina protein is essential for the determination of the R7 pathway in photoreceptor cell development: the loss of functional Sina results in the transformation of the R7 precursor cell to a non- neuronal cell type. The Sina protein contains an N-terminal RING finger domain Pfam:PF00097. Through this domain, Sina binds E2 ubiquitin-conjugating enzymes (UbcD1) Sina also interacts with Tramtrack (TTK88) via PHYL. Tramtrack is a transcriptional repressor that blocks photoreceptor determination, while PHYL down-regulates the activity of TTK88. In turn, the activity of PHYL requires the activation of the Sevenless receptor tyrosine kinase, a process essential for R7 determination. It is thought that thus Sina targets TTK88 for degradation, therefore promoting the R7 pathway. Murine and human homologues of Sina have also been identified. The human homologue Siah-1 [1] also binds E2 enzymes (UbcH5) and through a series of physical interactions, targets beta-catenin for ubiquitin degradation. Siah-1 expression is enhanced by p53, itself promoted by DNA damage. Thus this pathway links DNA damage to beta-catenin degradation [2,3]. Sina proteins, therefore, physically interact with a variety of proteins. The N-terminal RING finger domain that binds ubiquitin conjugating enzymes is described in Pfam:PF00097, and does not form part of the alignment for this family. The remainder C-terminal part is involved in interactions with other proteins, and is included in this alignment. In addition to the Drosophila protein and mammalian homologues, whose similarity was noted previously, this family also includes putative homologues from Caenorhabditis elegans, Arabidopsis thaliana.	28.70	28.70	28.70	29.00	28.60	28.50	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.27	0.71	-4.65	10	1309	2012-10-02 00:06:50	2003-04-07 12:59:11	11	16	738	7	396	752	2	133.90	53	60.55	CHANGED	IRsLAlE.+lAsplpFPC+aushGCslp.LPhpphscHEEpCca+PYpCPhss..ucCpWpGshcslhsHLhscHpshhp.pus.-lhaltsshshstussWhhsp............................pCaGcpFpLhhEth-ts..ssphaashlphhGspcpAcpFuYcLELtu..spR+LpWQuhPpSI+-shcpshcup.....DsLlhpscsuphFucsss.....Ltl+Vo	........................................IRNLAME.KVAsS....V.hFPCKYA.........SsGCclo...LP...aT....EKs-..H.....E.E.l.CEF....RP.Y.S.C...PCPG.......ASC.KW.QG.S.L..-.uVM.sH.Lhc...pH..........KS.I.T..T.L...Q...G....E....DI....V.FL.A.T.D.I..N....L.P..G..A..V..D..WV.................................................................................................................................................................................................................................................................................	0	90	187	279
+859	PF04938	SIP1		Survival motor neuron (SMN) interacting protein 1 (SIP1)	Moxon SJ	anon	Pfam-B_5071 (release 7.6)	Family	Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans[1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.68	0.70	-5.01	12	252	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	189	1	164	243	1	206.00	24	72.25	CHANGED	LhPl-tsD.s.t-aD.osPPcsstEYLR+V...........phEAppCPsVV.lAplssp+.hc+cQoV.hsl.s......ss.ssPcshsPohcWp....ppQlspFspsRpslsph+pchpsp.lDssss.P..pDp-tWc+FCLscp.................................c.uhsPhLohlp+hsQ.sslsplLEhLstW.hpEcshssp......luRWlYALLACL-pPL.s-spSslRpLAR+CuplRst...Lcpc.......c.-plsshNLlIslluRaFsQpD	...........................................................................................................................................thp......Ppss.EYLppV............................................ph.EAtphP...pVh...lu.p.h.....s.......p...p...h..ppp....ps.s.......s....s..............................sh.....ss.tt....h......P.s....pWp....pt.ltpFpphRp.pl..tp............t............p..h...t.t...t...hs...t...p.....h....................t..spptWp.p.hhhspp...................................................................................................................................Phh......p..h.l...p..hs..p.tpl.t...l.l.p.hh.p.a...htppt..h..s..p............................................hspWlauLLspl-..p..P..L..scspuhlRpLsRp.C..p.lR........hptp..............................th......h.....s..h..hlslh.sph.atQ.............................................................	0	65	96	134
+860	PF03530	SK_channel		Calcium-activated SK potassium channel	Griffiths-Jones SR	anon	PRINTS	Family	\N	22.90	22.90	23.40	23.40	21.80	20.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.68	0.71	-4.27	10	342	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	90	0	179	301	0	110.00	53	20.18	CHANGED	RLt+R+tLaE+RK+LuDaALshAhhGIllMVlEsEL.ohtlYs+..........................................uShYShsLKslISlSTllLLuLIlsYHApEI..........QLFhlDNGA-DWRIAMThcRlhhIsLELllCulHPlP..Gsa.hasas	............................................................+Lt+R+tL.FEKRKR.LSDaALlhuhFGIllMVlEsEL...ohs...s....Y..sK.............................................tShaShsLKCL.ISlSTllL.LGLIlhYHA+El.................................Q.LF..hlDNGAD.DWR.IAMTh-RlhhI.sLEllVCAIHPlP..GpahF.W........................................................	0	35	51	113
+861	PF02437	Ski_Sno		SKI/SNO/DAC family	Mian N, Bateman A	anon	Pfam-B_2013 (release 5.4)	Family	This family contains a presumed domain that is about 100 amino acids long.  All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation [1]. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain.  It is involved in various aspects of development [2,3].	20.00	20.00	21.50	20.40	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.50	0.71	-4.52	10	565	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	112	15	283	519	0	107.10	39	17.76	CHANGED	pP..P.hh...............SsPshssuDsssNEs+hlcLcGt+luuFlVsG-chLCLPQlFshhLKch..uLcplaT+lccLcIsslsCTs-Ql+ILRuLGAI.suVsRCtLIT++DhEpLhsshhsu	..........................................................s.....s..s...pss.pht.s.LcG.plusFh.l...sGpchlCLPQlhss.lLKch...ulpplas+hccLtIhs.spCss-QLcIL+s.hG.uls.uss+Cs.LIT+cDsEpLhpuhht......................	0	66	89	178
+862	PF01466	Skp1		Skp1 family, dimerisation domain	Bateman A	anon	Bateman A	Domain	\N	21.20	21.20	21.30	21.20	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.51	0.72	-3.95	62	1119	2009-01-15 18:05:59	2003-04-07 12:59:11	14	21	383	62	707	1038	25	74.70	46	40.61	CHANGED	lppWDt-Fl..pl..Dpp.....hLF-lIhAANYLsIcsLLDLsCppV.....AshIK.GKTPEEIRchFsIpNDFTP.EEE...pp.lRcENp..Wsh-	...............lppWDt.cFl...cl....Dps.....pLF-LI........l...........AA..NYLsIKsL.........LD.l.sCpsV.....AsMI.K.......G..K...o.......P.E.E...I.RchF.s.I.p.s.D.aTs..EEE..tp..l+cEstWs................................	0	222	328	583
+863	PF03931	Skp1_POZ		Skp1 family, tetramerisation domain	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.74	0.72	-3.87	17	1315	2012-10-02 01:20:04	2003-04-07 12:59:11	10	19	380	90	843	1197	12	61.60	32	39.07	CHANGED	phlhLpSSDscsFEV-ctlAhpStsIcpMlEDssssst......lPLsNVsucILsKVlEaCp+aph	.....................hlpLhS.oD.Gc..pFpVc.c.p.h..A.p.p.St.T.I....+.s...M..l....c........s.......s...tpsp..................lP.ls.N.Vsup....lLp.K.V.lpa.CpaHt.t................................	0	254	396	691
+864	PF00395	SLH		S-layer homology domain	Finn RD	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.04	0.72	-4.21	175	10758	2009-09-11 16:01:23	2003-04-07 12:59:11	15	704	543	2	2552	9714	348	43.60	29	13.80	CHANGED	sFsDlsstt..h....pslpthhptG.lhpGhs...ss........p....FpPspslTRu-hu	...........................FsDlssp..t.....ah.......ptl....ptl.s..p......t......G..llpGhs...........sG...............p..............FpPspslTRschA.............................................................	0	1376	2129	2319
+865	PF01423	LSM	Sm; 	LSM domain 	Bateman A	anon	Psiblast SMD1_HUMAN	Domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.91	0.72	-4.42	129	8102	2012-10-01 22:42:21	2003-04-07 12:59:11	17	62	2734	482	4356	6190	344	67.00	23	58.52	CHANGED	phLpphh.......sppVhlpLps..G.pplpGpLpuaDpahNllLs-spEhhttt.....................................ptt.l....s..hllRGsslhhls..	.........................h.....hh.......pp...V..pl..h..Lps........G..h.p.lp.G......p....l..p....ua..D..p.a..h....N..ll.Lp..s.spph..................................................................................................................................h...........t..hh..l.pGpslhhl...........................................................................................	0	1475	2432	3549
+866	PF02463	SMC_N		RecF/RecN/SMC N terminal domain	Bateman A	anon	[1]	Family	This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle.  The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics [1].\	\	 This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.	40.00	40.00	40.00	40.00	39.90	39.90	hmmbuild  -o /dev/null --hand HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.52	0.70	-5.11	29	12849	2012-10-05 12:31:08	2003-04-07 12:59:11	14	52	4778	48	3915	12683	5334	665.40	15	93.51	CHANGED	hlcclhlpsFKSat.cplhhsFstsFssIlGPNGSGKSNllDAIhFVLG.p.supplRupphscLIat...............pstsssppApVplhF........sppspt.............p..hslpRphhpsGs...ScYhI........NGcsssh.p-ltcLLtptsIshpshphlh.tsthctlthp.spc+p.hc-tsuhsphcpttpcphpplhpppppttph.hphpphptphpphtpppppt.ch.t.ttt...ht..hhhhph..h.tp..p..pp..t.ptpp.t...t..ptptph.tp.pp..t.ppp..p..pt..t.htpt.tt.tpph.php.tp...ppthp.tppp.tphppphpttpt.h.p.pt..p.hthtp.t.ttthpphtp.tttt.tttpp..hthttttpt.ttt.p.ht.tht.h....pphpt..phtpp....hp.hhpt..t..tt.tp..ph..t..t.tptt....t.h..t.t...pt.tt.h.thp.h....t.....tt....t.....t....................h..................h............hh......................h............................................................................................................................................h....h.........t..................................................................p.........t.tt.......t.......h.p...t..t...t..ttp.t.h.tp..t...pt..ttt.h.th....pt....t.tp.tpt.ttp.pp.hpt.tpp.tt..tt.p.p....pp.t...pt.tthtpt.hpt.tht.....ptt..t..p.p...t..t.p...t.pt.p.h..t..t.htt.ttt.tt.pptpp....htp.t.t..pp.pt.t.p.t..h....t.tp..hc....t..p.t..t.p..t.p....t..ttht..tthp...h.th.p.t.p..t.t.phtph.tpcpchhphhhctpppphpphhtthsthspshpthhphhthuuputhphps.psshssGlphsspsssKphpplp.LSGGEKoLsALALlFA.....lpphcPsPhYlhDElDAALD.pNsptlAphl+..ppscp.uQFIVlol+pshhptA....-plhGlhh.csuhsp	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lpplplps.F.t..........sh..............c.p.......h.....p.....l........p......h.......p.....s.............u.........h.....s.....s.l...........s..G..........NGu...........GKSs...l...........l...-......A.......l.....t.......h.......s......L.......G................p........s...s......p.......p.................h........R......s.......s.....p.....h.......p.....s.....l...Itt.............................t.....s.h.......s....t......u.....p.......l...p....h...h..h.......................................pp.p.stt..................................................t.p......l.h.........l..p...R...p.....l.....t......p.....s..Gc...........o..p....h......h.....l........................N...s.....p..........t.......s.....p.....h......p....p.....l...t.....p....h...h......t.....p........h...h......l......s...h...cs.phhttt.p.chhhhp.tthpttht.ttthtphpphhcpppttlpptppptpphtthhp.hthphpthtttt.tttt..t...t...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.tt.httthtthtthhpttpphhtthhtthhth.pth.h.hthhhhhsptt.tths.pshhtsshphssp.stpth.hhphh.S.G...G..E..h.........s..hh.s....L......A...L..h..h..u................................h.t...p......h........p...s......t......P....h.....h...l..h.DEl.-usL.....Ds..t...p.t.p.t....l...u.......p...h.l....p.................p.....h...s.............t.............t........s............Q..h...l...s...l..o.....p...........t....h..h.t...u......p...hhl.h.......t................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1352	2437	3292
+867	PF04158	Sof1		Sof1-like domain 	Wood V, Finn RD	anon	Pfam-B_9404 (release 7.3);	Family	Sof1 is essential for cell growth and is a component of  the nucleolar rRNA processing machinery [1]. 	25.00	25.00	26.10	29.90	22.10	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.98	0.72	-3.96	28	344	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	289	0	240	346	7	85.70	41	18.60	CHANGED	AsASE+lGllosRE+puhpYsptL+E+apahPEI+RIuRHRHlP+slhptpch+pthhcAc+R+EcNc+pHSKsup...shhsE+cK..pll	......ApASE+lGlhssRE+pthpYscsLK-+apahPEI+RIuRHRHlPKsIhpAtchc+hhhc.up+RKEtNcR+HoK.sp..hshhsE+cKhll...............	0	88	137	202
+868	PF01033	Somatomedin_B		Somatomedin B domain	Bateman A	anon	Bateman A	Family	\N	23.10	23.10	23.30	23.20	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.47	0.72	-3.99	73	1147	2009-01-15 18:05:59	2003-04-07 12:59:11	12	76	110	24	540	1024	13	45.40	33	10.31	CHANGED	s.pSCpuR...Cspshppst..........tCpCcstChp.hssCCtDYcphChtphs	........................tSCp.sR.....Cscthttsp.......................sCpC-.spChp..hssCC.DYpphCttp.t.......	0	152	189	320
+869	PF03700	Sorting_nexin		Sorting nexin, N-terminal domain 	Finn RD	anon	Pfam-B_29150 (release 7.0) 	Family	These proteins bins to the cytoplasmic domain of plasma membrane receptors. and are involved in endocytic protein trafficking.  The N-terminal domain appears to be specific to sorting nexins 1 and 2.	21.00	21.00	22.00	29.10	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.82	0.71	-4.04	5	151	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	39	0	51	126	1	120.90	46	24.42	CHANGED	AuEREPPPlsDscsp........EsE.........-pEEGEDLFTSssSs.cossSSP-suslPuE-uS.TsSNGPKssplLLDDDcEDLFAEAT-EVSLDSPE...RcsILSopsSPAlTPVTPoSlIsPRlE.hu......aDRShEElEEE	.............AuER.PPPhsshcsp...........-...E.............p.p-GEDlFT.u.....ss.....s..s........c.......sp..ss.p...psu.LPhps.s.....S......ppN..G....+tpp...Dp-.pDLFA.....-..AT.ElSLDSsp.......+cs.....h.po.....S..ssp.s...T...s.o.oh.t.P................ohEElEEE..............................	0	2	7	21
+870	PF04130	Spc97_Spc98		Spc97 / Spc98 family	Bateman A	anon	Pfam-B_3531 (release 7.3)	Family	The spindle pole body (SPB) functions as the microtubule-organising centre in yeast. Members of this family are spindle pole body (SBP) components such as Spc97 and Spc98 that form a complex with gamma-tubulin. This family of proteins includes the grip motif 1 and grip moti 2 [1]. Members of this family all form components of the gamma-tubulin complex, GCP [2].	27.00	27.00	27.30	27.20	26.30	26.80	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.85	0.70	-6.19	120	1599	2012-10-02 13:20:28	2003-04-07 12:59:11	8	21	316	1	1118	1585	20	536.90	16	64.78	CHANGED	-l......LhsL.hGhs.s...hhphpt.........................tpaplspsh....................shps.............llpplhchuphapplp..pahp..tptt...................................uhhhpuhssulpphLp.sahp.hlspl-pphhp...............................................h.oLtplhthlp..phhphlphLtplspp.......h.....................................................t.tthpGuplLshlhpph....t.p.Gs......php.p....hhpplhppstpsa...hc.................................hlppWl..hcG......p....lp....D.....................t...E................FFlpps........................................tttpspphWpp.........p..........apl......pps......................................hl....P..................................sFl..psh...uppIlhsGKslshl+phstptthtpstt............................................................................................................................................................................................t.hp.hpssphpph....................................................................................................................................................................................................................................................................................................................................................................................................lppthphss..pplhpl............lhpph.cLh...pc.Lpsl+pa.......hLl....spG-Fhsphhpphtsplpcsspphpstphpshhptshttsssp......................................................................................................................................................................................................................................................................................................tptpthpttsstthtptpshpuhsshsLpYpls..hPLslll..otp............................slppYpplF............paLhpl++sp........htLs.phWtp.p...........t............................t..tth...hpph.......hhl+pchhpFlpslptYhh............h-......VlpssWpp.hppplp....................................................................................................................................pspsl-p.l......hptH.ppaLsslhppsh	......................................................................................................................................................................................................................................................................................................................................................................................................................hlhhh..Gh..u...hh..hp.....................................................th..h..t.......................h..s.pp...................................lhp.p.lhthu.hhh...tlp...pahp....t.........................................................................................................................u.hhpuh.ssul.p.p.hLp..paht...hlh.p.lcpp.h................................................................................................................h.oL..plhhhhp.....hhh.hh..ph..Lhtl..spph.........................................................................................t.hpus..tllshlhpth.........tp.Gs........................ht.p.................hh.plh.t.tst...psa...hp.............................................hlppWl....hpG...............................l.......D..........................s.................hp.......E................Fh...lppp..........................................................................t..tpphapp.............p......................................................apl..........ptp..............................................................................hl.......P...............................sa..l....tph......upplhhs.GKt.l...p.h...l......+ph......st....t....t..h..tt.....t...................................................................................................................................................................................................................................................................................................h......th.th.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lp.pthth..s....s.ptlh.ph..................hh.....p...ph...p.....Lh........tp.Lp.sl.+p.a.......hLh.....tpG...-hhtt..........hhp................h.....p........tl...p.p..s......p..t...h....t....h.....t...hp.s...h...h..p....s..ht..t..t....p..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....h...p...t...t...h..t..............................s.......t...shs.shpL.p.....Y.p.l.....hPlshll...s.p..............................shppYphlFpaLhpl+chph.Lp..ph....aht...........t.......................................................................................hpth..........................hhlptchhh.Fl.pplt.Yhh................hp............................llpspapp..h.pplp...........................................................................................................................................p.s.p.sh-p.l...hthHtpaLsphhtt.....................................................................................................................................................................................................................................................................................................................................................................................................................	0	419	621	910
+871	PF04435	SPK	DUF545; 	Domain of unknown function (DUF545)  	Finn RD	anon	Pfam-B_429 (release 7.5)	Family	Family of uncharacterised C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.	22.10	22.10	22.20	22.10	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.20	0.72	-4.09	37	379	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	5	0	372	368	0	102.60	21	29.69	CHANGED	hs+hMsFLl-pTKDs.sE...Pls.spplFp-Fsch-ssshs...tpsYhp+F+ppLAPpMsphssYSIEpRlRlMFuhuucVp--.FLpplcppGs.VpLD-ppRIs+YsSpDGplpL	.........................................h...hhpalhppspph..p.....Ph.....htplhcca.tpp.p.t.s..tts.............hpsh.hp....+hp..p..tl.t.....plpt...h.p.p....ashcs+l+hhFshus.sVs.p.....p...FL....p................c....L............c.p...p.u.p..V..p...l...D.c..p.pR...I..h.cYpu.pctth................................................	0	69	86	372
+872	PF04014	Antitoxin-MazE	SpoVT_AbrB;	Antidote-toxin recognition MazE	Kerrison ND, Bateman A, Finn RD	anon	COG2002	Domain	MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation [2], and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules [3]. MazF toxin functions as an mRNA interferase, cleaving mRNAs at ACA sequences to inhibit protein synthesis leading to cell growth arrest [4].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.13	0.72	-4.18	145	4979	2012-10-01 20:57:08	2003-04-07 12:59:11	13	18	1997	32	1417	3448	534	45.50	23	42.49	CHANGED	hpsssshtlslPpchtcph.....slct...Gcpltlhhp..ss..tlllp.hppttp	..............+hsppstlsIPpclc...cpl........slpt......G-plplhsp...ss..plllp.ht....st..........................	0	482	933	1183
+873	PF00622	SPRY		SPRY domain	SMART	anon	Alignment kindly provided by SMART	Family	SPRY Domain is named from SPla and the RYanodine Receptor.  Domain of unknown function. Distant homologues are domains in butyrophilin/marenostrin/pyrin homologues.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.61	0.71	-4.04	68	8383	2009-01-15 18:05:59	2003-04-07 12:59:11	23	306	478	24	4618	6876	377	121.50	19	17.99	CHANGED	sG+aYaElcltstst........hplGhsppss..................................................................sttp...hsucc.tuauapstt.pphtssps........tthspthpp.........schlGshlDhpss....plsFt.tNGptht......hsFp.psphs...thlaPhhsht.....spthphphstht	.........................................................................................................................................G+aYWEVclsspst..............................htl.Gl...s..ppsh....................................................................................................................................................t...s...t..t..p.....h..hu.p...s....t...s..a.s...h.....p.h...p....s.......p..t...a...t.s.tps....................tph..s....thpt............................................scplGlh...l.....D.....h..csG.................p..ls.Fh...p.s.s.pt...t.............hhsFp......h...phs.............ts.l..aPhhsh.......................................................................................	0	767	1604	2913
+874	PF03105	SPX		SPX domain	Mifsud W, Bateman A	anon	Pfam-B_502 (release 6.5)	Domain	We have named this region the SPX domain after (SYG1, Pho81 and XPR1). This 180 residue length domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N-terminus directly binds to the G- protein beta subunit and inhibits transduction of the mating pheromone signal [3]. This finding suggests that all the members of this family are involved in G-protein associated signal transduction. The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 Swiss:P17442 from Saccharomyces cerevisiae and NUC-2 Swiss:Q01317 from Neurospora crassa, are also members of this family [see 4,5].  The SPX domain of S. cerevisiae low-affinity phosphate transporters Pho87 and Pho90 auto-regulates uptake and prevents efflux. This SPX dependent inhibition is mediated by the physical interaction with Spl2 [6] NUC-2 contains several ankyrin repeats Pfam:PF00023. Several members of this family are annotated as XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with murine leukaemia viruses (MLV) [1].  The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae [1,2]. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction and may itself function as a phosphate sensor [1].	26.90	26.90	26.90	26.90	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-4.62	168	2197	2009-01-15 18:05:59	2003-04-07 12:59:11	14	120	337	0	1617	2267	25	161.90	18	28.52	CHANGED	MKFu+pLppphl.....PEWpsp.....YlsYcpLKKhl.+plpptttpt....................................................................................................................................................................................................................................................................................................................................................................................ttpthpp........cspFhptL.-pELpKlssF....................................ap.......p+tp-hhc............+hp..........tLppplpphttptstttttt......................................................................................................................................................................................................................h.pthtpLcptlhchhtplptLcsatpLNhsuFpKIlKKaDKhh...spp..hptpahpphh	............................................................................................................................................................................................................................................................................................................h+Fup.h..t..................................ta....t........ahtYp..................hKp...l.h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.Fh....h.p.phtc.......l..a................................................................................................................p.tth...................................pht................h.......t.......................................................................................................................................................................................................................................................................................................................................................................................................................................h..th..thh.th..L.pa..............t.lNhhu.h.KlhK........KaDKhh..t..............t......................................................................................................................................................................................................................................................................................................................................................................................................................................	0	468	969	1406
+875	PF03125	Sre		C. elegans Sre G protein-coupled chemoreceptor	Mifsud W	anon	Pfam-B_352 (release 6.5)	Family	Caenorhabditis elegans Sre proteins are candidate chemosensory receptors. There are four main recognised groups of such receptors: Odr-10, Sra, Sro, and Srg. Sre (this family), Sra Pfam:PF02117 and Srb Pfam:PF02175 comprise the Sra group. All of the above receptors are thought to be G protein-coupled seven transmembrane domain proteins [1,2]. The existence of several different chemosensory receptors underlies the fact that in spite of having only 20-30 chemosensory neurones, C. elegans detects hundreds of different chemicals, with the ability to discern individual chemicals among combinations [1].	20.00	20.00	20.00	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.17	0.70	-5.53	19	368	2012-10-03 04:04:29	2003-04-07 12:59:11	13	8	32	0	339	323	2	246.30	15	87.61	CHANGED	Mllphtss.....hhalPlahhspsh....hphlhslh-llhallssYlhhhslhlhh+lphFHpNhhhlslshhshWaEhllGKhlshsYchtlh....sht........hphhthWTs-.schl.VpshsslphlhhuuFLphHah.hohlaulhslslERshAShhlcsYEpps+haIs.lhLlhltQhluIshu..hhhlhphls.hlhhhhsahlssslushhahhlcphNpphppchcs.p.+...+..haTLSpRFQlKENl+sl+lhp+llhsllshlslsshslhhLhacl.....hP...s.hhsahhEshlhl.PhhIshshhholstW+pcapphhs.hhh...hc...hhptphthp.h.h.psppcphphETchYFpQLscSWp	....................................................................................................................................................................................................................................................................................................................h.....h......h...............hh...h.h......hh.hhhhERhhAohhhtsYE...p..p............p.............h........l...h.h...l......h.....h.h.......................hh........s..h...........s................h.h.h.h.........................h........h..............h...............h....h....h............h.....h.......hh.......h...........hh...............shh.............h.....h......h..h.h.hh.....hN.phh.p..p...h....p..t............t.............Yo.Lu.t+aQlpENl+.shp................hh..pt.h....h..h.s.h..h..h.h.h.h............h.h.hh.h....h....h..h.........h.p.h.............................hhhh.h...h.p.....h....hh..h..sh...hh.....s.h...hhh...............tap.p..h......h.....................................................................................................p......p.....aF..h............................................................................	0	115	150	339
+876	PF04086	SRP-alpha_N		Signal recognition particle, alpha subunit, N-terminal	Wood V, Finn RD	anon	Pfam-B_7342 (release 7.3);	Family	SRP is a complex of six distinct polypeptides and a 7S  RNA that is essential for transferring nascent polypeptide  chains that are destined for export from the cell to the  translocation apparatus of the endoplasmic reticulum (ER)  membrane [1]. SRP binds hydrophobic signal sequences as  they emerge from the ribosome, and arrests translation.	25.40	25.40	25.70	25.40	24.80	25.30	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.96	0.70	-5.02	27	323	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	265	2	237	320	1	243.40	23	40.50	CHANGED	ssslNuLIpsVhlEE+s.............usss.ap+-....paTLKaphspEhsLlFVslYQplLpLsalDKLLssl+phFh-hY..................cspLp..p.psph.th....pFcch.Fcphlc-hEpsupt.tpssphhpphcpppcs.hospshh...s...t.........tpp.tttptt.pspsssssssp.t..s.........lhstc.h......ppRt+hhtphtst...........sssscptos+pstts+...pshKchRhWDtsG.....spc-stsLDaS....t.ss.tt..ssssss.ptlstpshtptTtKGp.hh.tDl......s-Esc	.......................................................................s.tslNsLIpsshlp.ERs................usst.a..pp-.....thsL+aphsN-htLlFVssaQplLp..L...salDcLlssl+ph.FhchY........................tsplt...t......h.t............pFsp....Fpphl.....pph.Eppup....pts....t.h...pphpp....s.p.c.stt..s.stshh..t.st..t............................tttttttt...tt....t.....s...psp.s....s.ptt.....t......................h.ptchh...............ppRtchhppttt................................t.pts..p....t.s.....ppt.t..p...pttKp.Rh.Ws.su......pppstt.LDaS.........ssttt.....t....t....t.ht..ttphh.tp..p.G.p.h..h-h.........tp...t.........................................................................................	0	80	131	196
+877	PF00448	SRP54		SRP54-type protein, GTPase domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This family includes relatives of the G-domain of the SRP54 family of proteins.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-10.97	0.71	-4.87	55	11362	2012-10-05 12:31:08	2003-04-07 12:59:11	17	39	5002	94	3068	9263	5175	195.50	41	44.83	CHANGED	ssVIhhVGlpG..uGKTTThuKLAphhpcc...Gp+lhllAuDTFRuuAh-QLcphupphsl.hhs...tttts...DPsslshculppuKppt..hDllllDTAGRlppcpsLhcELpclpcll........pPs-slLVlDushGQsuhs.QA+sFp-sl.s.lsGlIlTKlDGsA+GGusLSlstthphPItFlGsGE+l.-DLcsFcscpals+LLu	...............................tVlhhlG.lp..G..sGKTTolGKLA...p...h.h.......p.....p........p...........s.............++....VhLsA.u..D..s....aR..s...A.A...l....-..Q..Lp.s.h.u...cp.....s..........s.........lslhs........................ttpss....cPss......l....sh.........c..Al.p.p..A..+....t..c.t.............hD..lll.....lD.T...AG.RL.p...h..c.......ps.LMpE.L.c.c..lp..csh...............................s.P..p.Esl.LVl.DAhT.G.Q.s.A....l..............s..p.Act...F..........s.....-........s............l...............s................l..o.....G..ll.L.TKLDG.s.A.+.G.Gs.slol..t...........p.....h.s.......h...P..I..+a.lGsGE+l..-DLcsFp..s-chsstll...................................................................................................	0	1055	2004	2604
+878	PF02881	SRP54_N		SRP54-type protein, helical bundle domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.47	0.72	-3.87	189	9665	2009-01-15 18:05:59	2003-04-07 12:59:11	14	28	4872	82	2570	7341	3204	77.20	29	17.42	CHANGED	L.ppsLp+shpplssp...hhh.sccpl..cchlc-lEptLlpADVuhpsspcllcpl+c.t....ht.............tptlsstpplpphlpcpL	...........................LpcpLpcohps..ltup...........shl..sccsl...c-hhcElctsLLpADVulplscchlppl+c.tlu................hcslssspplhcllp-EL.................................	0	854	1649	2165
+879	PF02978	SRP_SPB		Signal peptide binding domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.10	20.10	20.10	20.10	19.40	19.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.52	0.72	-3.77	124	4974	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	4793	40	1356	3784	2145	100.10	43	21.33	CHANGED	pFsLcDhhpQlpplpKMGslsplhpMlP.Ghsth......p.tp.ths.-+thc+hcuIIsSMT.cER..psPcll.................................ss...SR+pRIApGSGsslp-VscLl...KpapphpchM	...........................................pFsLsDFl-QlpQh+pMGshsslh....sMlP..G.huph.........t.t.p.phs..-+plp+hcAIIsSM.T.pER.....psP...-.ll.............................................ss.......SR++RIAtGSGsslp-..VN+Ll...KQFpphp+MM..............................	0	465	879	1145
+880	PF00436	SSB		Single-strand binding protein family	Finn RD, Bateman A	anon	Prosite & COG2965	Domain	This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.88	0.72	-4.16	70	10092	2012-10-03 20:18:02	2003-04-07 12:59:11	20	7	4898	110	2030	6702	2778	102.00	30	65.61	CHANGED	lN+VhL..lGpLspD..P-lRhst.sGsslssFolAssc...phps.......tsptcpps-ahplslasc.hAEhhspYlpKGs.hlhVpGcLps.cpapspp.G....pc+hss-lhsc....plphL	...........................................hN+VhL..lGpLspD......P.E..l......R.hss....s....G......s.....s.....V..u..shslAssc.......paps...................tsp.tc..cp.s-..a..hsllh..a...s....+....h..........A...E....s.........s.s.........p.....a.....l........p.K.G..s...hlhlpG.cl......p.......o..Rp..ap..spp..G............pc.c..h.s...sElhsp.....pht..............................................	0	640	1330	1739
+881	PF04503	SSDP		Single-stranded DNA binding protein, SSDP	Mifsud W	anon	Pfam-B_2031 (release 7.5)	Family	This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.	21.70	21.70	22.10	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.22	0.70	-4.67	5	325	2009-09-11 22:41:17	2003-04-07 12:59:11	8	5	59	0	134	249	0	206.60	62	77.49	CHANGED	EHSSEAKAF.............................HDYSAAAAPSPVLGNhPPGDGMPsGPlPPGFF..........................................................................QPFM....................SPRYPGGP.....RPPLRhPNQPsGGVPGSQPL.....LPuGMDPT.RQQGHP...............NMGGPMQRMTPPRGMsPL..GPQ................NYGGuMRPPsNuL....uGPGMPGMNMGPGuG...................................RPWPNPsoANSI.......PYSSuSPGsYVGPP.................................GGGGPPGTP..IMPSPADSTNSuDNMYTlMNsVPPGssRuNFPMGPGSDGPMGGhGGMEPHHMNG..............................SLGSGDMDSlSKNSPNNhSGLSNs.....PGTPRD.........DGEM..GGN	..........................................................................S.............AA.u.........A....PSPV......hG.shs.Ps.-u..M...ssGPh.s.P.GFF.....................................................................................................................................QPFM....................SPRas.GGP.....R..PslRhs.sQ....s.u..ul.PGoQPL.....LPsuMDPT.Rt..Q.G.HP............................sMGG.sMQR...M.sPPR.G..M..ss......h..GPQ.......................sYGu..uM..R..PP.Nu.L.............GP.u.MPuhNM.GPG.u..t.......................................................t.PWs..sP.su.NSI.......sYSSuSPGsY.s.GPP.................................GGGGP..P..GTP..IMPSPu.DSTNS......u.-NhYThhNs.lsP......GssR..sN......F....PMGPGs-.G.PM...uuh.u.uM..EsHHhNG....................................................SLGSGDhDul...sKsSPs.shu.hsN......PGTPR-.........DuEh..s......................................................	1	13	25	69
+882	PF05030	SSXT		SSXT protein (N-terminal region)	Moxon SJ	anon	Pfam-B_4900 (release 7.6)	Family	The SSXT or SS18 protein is involved in synovial sarcoma in humans.  A SYT-SSX fusion gene resulting from the chromosomal translocation t(X;18) (p11;q11) is characteristic of synovial sarcomas. This translocation fuses the SSXT (SYT) gene from chromosome 18 to either of two homologous genes  at Xp11, SSX1 or SSX2 [1].	21.00	21.00	21.20	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.11	0.72	-4.39	9	329	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	133	0	185	312	0	63.70	52	20.29	CHANGED	RG............tsplsppslQ+LLDENspLIpsI.-YQNKG+AsECsQYQplLHRNLlYLATlADusps.hpspts	..................tls.ttIQ+hLDENppLIpsIh-hQN.....KGKss.....ECs.Q....YQphLH+NLlYLAoIADus.s.t...s.............	0	45	78	128
+884	PF01852	START		START domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.20	0.70	-11.09	0.70	-5.00	18	2507	2012-10-02 19:24:03	2003-04-07 12:59:11	14	50	457	40	1330	2394	50	186.50	16	33.31	CHANGED	plttpshpphhphspsspssWhp.s......t.pstspshpphs.s.........pscshRtpshV.hsss..lspplhcsh.....pWsppht....pspslpslssu.......sslphhhsphhs.sPlsP.R-ahhlRht+p.......ssssaslsshSlsssptss....ptshlRscphsSGhllpssssGh...........oplsalp+s-lcuphs..p.lh+slhpsuhshss+p..hhusLpptspp	.................................................................................................................t....................t....W............................h.t...h................................................h.h.h.+.h..........s....h...l.....hs.st.........h.ht....plhpp..........pWspphh.........................ph.p.ll.p.p.l.s.ss...........................stl..h....h......h..h..h..p..h.......h..................s...h..s..........s..RDh.l...h..l.R..hhpp.......................tss.s.h...h.ls.....s..h.....Sl..p.............ts........p........h.........s............ttshl..R...up....h....h.s..u.s..hl...l....ps....h...s..ss............................s.p....lsal..h..p..s-.........p...u...h.h.s.....t.l.hp.hhttth........hhp..h..............................................................................	0	408	676	997
+885	PF01740	STAS	SpoIIAA; 	STAS domain	Bateman A	anon	[2]	Domain	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.28	0.71	-10.12	0.71	-4.67	68	10190	2012-10-02 18:52:36	2003-04-07 12:59:11	16	126	3448	44	3587	10260	1791	111.40	16	25.99	CHANGED	thphpttssl....hllclsGs.lshssustlpcpltphhtpt...................................................................................phlllDhssl..shlDosGltslhphhcphp.ppusplhlssspspltch.........lptsuhh.chh..........plhtolppA	..............................................................................................................................................................................h........sh.......hlh.p.l.p.G.s..l...as..s.u.p.t.h.pp.p.l....t..p...hhptt........................................................................................................................................................................................ptlll..D.........hs.s.l..shlD.sou.l.p.s...L....tp..h.h......c....p.....hp........p..........p....u....h..p...........l.h.l..s...s......l......p..s..p...lt..ph.........lp.t..s.s.h...t...............................................................................	1	1204	2247	3019
+886	PF03015	Sterile		Male sterility protein	Griffiths-Jones SR	anon	Pfam-B_1115 (release 6.4)	Family	This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila.  A sequence-related jojoba acyl CoA reductase is also included.	21.40	21.40	21.40	21.60	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.03	0.72	-3.72	13	894	2009-09-15 11:21:16	2003-04-07 12:59:11	14	22	172	0	591	1002	19	92.10	26	18.78	CHANGED	haHhLPAhhhDlhhhLh..GcKPhhl+.la+KI+...pslslLphFshspWpF-scNhpcLppphs.pD+c...hasF.DhsslsWc-YFpps.lhGhRpYLhKE	...............................................hahlPAhhhDhhhhlh.......Gp...c.....s..h....hh+...lh..p..+lp.......cshph...hpaFsh.p...p.....W......pF.ss.sN...h.pp.L.h..p..p.....h....s...s..p.Dc.c.............hFsa.Dhpp...lcW.p..c.Yhpsh.lhGh+p.Ylh+-.............................	0	181	263	487
+887	PF02544	Steroid_dh		3-oxo-5-alpha-steroid 4-dehydrogenase 	Bashton M, Bateman A	anon	Pfam-B_1713 (release 5.4)	Family	This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor.  The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development [2].  In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally [2]. A related enzyme is also found in plants is Swiss:Q38944 (DET2) a steroid reductase from Arabidopsis.  Mutations in this enzyme cause defects in light-regulated development [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-11.02	0.71	-4.44	10	1178	2012-10-01 22:51:20	2003-04-07 12:59:11	11	15	411	0	741	1677	1096	142.80	25	50.78	CHANGED	sshPlhhlstAsh.FsshNGhlQuhahuaats........s-sahs..+hllGhhLalhGMhINh+SDpILR....pLRKsGpsuY+IPp.GGlFEYVSsPNYFGElhEWlGaALssWShsuluFAh...FohssLssRAhpHHpWYp+cF.ccYP+oRKhLIPFla	..........................................................................................s....h..hh.s....a.h.hs.h.............h..h...............................................h.....................t...h...h..h......u.h.hlF.h..h..u...hhNhpsc..hh.Lt..........................sL...R.....p......s......u......p..........p.......t...........a.....p......I.P......p......u......t....h.....F....p....h....VosPNYhhEl.l.t...W...l.u..............a...s......l.........h........s.........t.......s..........h........s.........s....h......h.....F....h...h.................h.s...h.....s.....p..hs..........h.....A.......h......t.p.....+....c...............h....Y...h...c..c.......F......p......c....Y....s.....p.p..R...t......s....llPalh....................................................................	0	231	405	592
+888	PF02910	Succ_DH_flav_C	succ_DH_flav_C;	Fumarate reductase flavoprotein C-term	Griffiths-Jones SR	anon	Structural domain	Domain	This family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.29	142	8079	2009-01-15 18:05:59	2003-04-07 12:59:11	15	23	3914	101	2187	5856	3967	117.20	28	20.41	CHANGED	+pcLpchMpppsGlhRsppsLpcul........pclppL.pcch.p.p.ltl.t-puthhNssLhcslELtshlphAphhshuAlpRpESRGAHhRpD..aP.......................pRDD.................psah+HTlhhhttps..............l..phcsVphp.................PptRsY	..................................................pclpphMt.c.t.s....u.....l....h.....R.....s.....s.....c..tL.....pcu.l................ccl.p.t.l...p..pc.........h.........p.....p.........h.............t.............h....................c.............p.......s.............h.....h......N.............p.....s............h...h.p.sl...EL.t...shlplAphhshuAhtRcES..R..G...u..Hh..R.......D.....aP......................................cRs.D...................pah..ppsh.h........t.tt.....................h.th.p.l.............................................................................	0	688	1387	1840
+889	PF00884	Sulfatase		Sulfatase	Bateman A	anon	Pfam-B_784 (release 3.0) & Pfam-B_7393 (Release 8.0)	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.00	0.70	-5.24	59	18763	2012-10-03 20:55:17	2003-04-07 12:59:11	18	130	3819	26	4719	15548	10237	301.40	17	53.82	CHANGED	.sllllluEohtts....shshhuhsh...................ts...sPtl.........tths..ppGlhassha..ussshTssoh.shlouhs.tphs....................shhpp.sslsphhppt.GYpo.hht....shhspps.............................shp..hhsh.s.tsthtptt..shh................................................................................s.Dptlhsphhph.....hppt.scshalhlthhusH.................hhsscaspphtth.s.h.t.........................................................................phhssYssslthsDphlspllptL..pthtcsThllah.uDHG.tl......................................................th.htsttt.tt.ptthplPhllahssthtp...........ttscthhu....p.Dlhsollshs.uh	......................................................................................................................................................................................................................................................................Nllhl.h.....s-.shtht........................th.s.h...h..u.....th.............................................................TPpl.........stht................ppu...h...h...F.s.......s........h...a..........ss...s.........s......h....s........s..s.......o...h......s...s...h.h...o..u....h...h...sh.p....h...s...............................................................ths..tp...t..s...l.....s.p.h......L....p.....p...t....G..Y...p...o...........h....h.....t..t..................s....h.....h...s..pp.t........................................................................t.sa....p..........h...h......s.....................h.....t.....s....t...h.......t....t......t...........t..........................................................................................................................................................t..h..h.s...p...h....h.....h...p...p...s..h.phl...................ppp...ppPa.h.l....h.......lt.h.....hs.s..Hh.....................................................h.s...p..c.....a......p..p.....h.....t....t....h............................................................................................................................................................phhs.s..Y..h.s..s..l..p.....h..h....D.p...t.l...u...pl....l............p..t...........L.....c...p........p......s........h...........h........c...s...T.....ll..lah..uD..H.G..t.....h.tt...................................................................................................................................th.h.t..t..t..p..t.............h..h.....p..t..t..h....+...l...P..h.......h......lh..h..s..s..t..htt....................................th.pt.h.h.s..............thDl.hsTlhphh.s...........................................................................................................................................................................	0	1780	2902	3885
+890	PF00685	Sulfotransfer_1	Sulfotransfer; 	Sulfotransferase domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_87 (release 2.1) & Pfam-B_1885 (Release 7.5)	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.73	0.70	-5.14	45	4587	2012-10-05 12:31:08	2003-04-07 12:59:11	22	172	680	97	2665	5498	3822	230.10	16	64.36	CHANGED	ssDlllsoaPKSGTTWlpcllsh...............lhspsch....phhppshl....hsphPhlEh............................................................................shtphpph.uPR.lhp..oHhshthhs.shhpspsKlIYlsRNP+DshVShYaatphht.............hh.tsss..ap..........phh-hFhp..............GplshGsaacHlcsWhp..hppppplLalpYE-h+p-Pppplp+ltcFLGtshs......t.lppllcpsoFpshKss.ssshs...tt..........p.ssahRKGhsG-W...+sahTs.p.s-chDchac.......cphpsss	.................................................................................................................................................................................................................phhlhsh..+..s.......G...T..s...h.h..p.hlt...............................................................................h.p.ht....................p.p...........h........................p....h..h........h......l.p...h.............................................................................................................................................................t.......t.....h....t.....t...h.......................h.........................................................................................................................t...............p............s...K....l....l....h..l.h..R.s.P..t.-...h...h...hS...h...a..p..h..h..t.t.ht...................................................................................................t......hp...........................................ph.h.....p.....h.h......t.................................................................................s..t...h.......h.....u...........a...h...p....a....l...p...t...a...hp.................hh........t...p..p....l.......h..h....l..p..Y..E-........h........h........p......c........s....t..t...p...l...pc.l.h.c...F.L..Gh..s........................h...t....h...h..p..t..h..h.p.....h...p....t...........................................................t...h.h.tp..s......tth.........h..hs...t..t.hpt.h................................................................................................................	0	952	1358	1975
+891	PF03567	Sulfotransfer_2	Sulfotransfer2; 	Sulfotransferase family	Finn RD, Bateman A	anon	Pfam-B_3050(7.0),Pfam-B_5394(7.7),Pfam-B_7836(10.0),Pfam-B_5040(7.5)	Family	This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST).  Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development [1].  Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.78	0.70	-4.70	66	2144	2012-10-05 12:31:08	2003-04-07 12:59:11	9	38	506	1	1196	2133	483	218.30	15	67.30	CHANGED	pchhlssca.pllaChlsKsusoshpplhhhLts.................hpps.phs.....pshsp.p..h...ptthtphsphp.pph.tpthp.t........................................hhpFhhVR............cPhcRllSuapsKhh.........htphh.upphhphhc................t.....t.spapcFhphlhstt.......pht......hsp...H..............ats.....htp.hshsshh..cachluphEshp....cctshlhphhsh....shth....phsp.................pppppsssphttphhhphs.thhctlhclYph.DatlF.sYs	..........................................................................................................................h...........ll.ahhl.Ksusosht.phhh.h.h.t...........................................................ht.......th....................tth.h.......................................p............hh..ph....s.ph.....tt.......ht..p...............................................................................................................................hhhhhhlR.............cP...hp...R..h...lS..t...a.h..t.h.h..........................t..h.........t.t..h.hpthp..............................................................t....hshp..p...F.h.p...h..l.h.s.t....................t...........s.............p......................................................h.....................ht..h.p.....h..h......pa.s.h.l.Ghh...E.php............pp..h.t....h.l...p.h..h.sh...............h...........ph.t..............................................p.......t.......h..t.h......h..s.........t.hphh...phh.h.Dh.ha.ta.............................................................................................................................................................................	1	489	622	928
+892	PF04935	SURF6		Surfeit locus protein 6	Moxon SJ	anon	Pfam-B_5497 (release 7.6)	Family	The surfeit locus protein SURF-6 is shown to be a component of the  nucleolar matrix and has a strong binding capacity for nucleic acids [1].	22.00	22.00	22.10	22.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.72	0.70	-5.04	29	306	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	262	0	222	303	4	204.60	26	49.88	CHANGED	hppRptllcp+R++cctc+p+++.pcRpct+ppcp...spcsctpsspppttts................................pssstpstsslsFsplpFs-sptsspshphhcpptpph.......t..shKphLp+lEs++p+LpphcEp..............Ktt-lc-KppWppAhh+AcGhKl+DDp+LL+KALKRKEppKcKSppcWpERpppVpcphppRQKKRc-NLpcR+csKtpK+hppt.+pKG..+hh	...........................................................................................................s....thhpt++p+c.ctc+t++.+.pp+p.ct+tccp...........tpc.tp.t.t.spttpt.t..t.........................................................................tpsttp..tssslsF.uplt..hs-spths...pphpphp..p...t.t.t...............p....shcp.hL.pclct+cp+Lpplccp..............Kttclcc..KptWpsAht+AcG.K.....V+..D...D........cLL+KulKRK-ppKcKSpcc..Wc-RpctVpcph....pp....RQcKR...c...c.Nlc.pR+cpK....t..p++hppt.ppKt.................................	0	74	123	186
+893	PF01805	Surp		Surp module	Bateman A	anon	Bateman A	Family	This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding [1].	21.10	21.10	21.10	21.10	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.50	0.72	-4.31	64	1689	2009-01-15 18:05:59	2003-04-07 12:59:11	15	52	309	8	1115	1679	12	53.40	30	10.94	CHANGED	.hplIcpoApaVscpG.pFEt....hlhp+p...ps.spFsFLp..ss.sshasYYph+ltphp	................hplIc+hAp.F.VA..+..sG......p..FEp......hlh.p+p.....tpN..sp.........F..s.FLp......sp.ss....hasYYph+ltph..............	0	351	557	826
+894	PF02201	SWIB		SWIB/MDM2 domain	Bateman A	anon	Bennett-Lovsey R	Domain	This family includes the SWIB domain and the MDM2 domain [1]. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the  p53 binding domain of MDM2 [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.54	0.72	-4.30	41	1464	2009-09-11 13:54:42	2003-04-07 12:59:11	13	39	457	79	836	1368	324	74.50	28	17.21	CHANGED	hs+.h.lo.pLtphlGssp...h.oRs-llctlWpYIKp+sLQDPpsK+hIhCDppLppl..Fts.cp.lshhplschLspHhh	..................................t.htlsspLtp..hl....Gtpp.......h.oRspllptl.WpYIK.........ppp....L.............QD.sps+.......+.h.....Ih..C.D.cp.Lpp.l......Ftt...pp......l...phh.pl.schl.stah.......................	0	228	451	658
+895	PF04434	SWIM		SWIM zinc finger	Aravind L	anon	Aravind L	Domain	This domain is found in bacterial, archaeal and eukaryotic proteins. It is predicted to be organised into two N-terminal beta-strands and a C-terminal alpha helix, thus possibly adopting a fold similar to that of the C2H2 zinc finger (Pfam:PF00096). SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts [1].	19.60	5.00	19.60	5.00	19.50	4.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.58	0.72	-4.45	88	3643	2009-01-15 18:05:59	2003-04-07 12:59:11	12	91	1791	0	1241	3096	130	38.50	23	6.69	CHANGED	apVplt......................ptsCoCthaph......pthsCpHhlAlhhtht	.............................................................tspCo.Cs........................tsh.hC+Hhlulhh...h...........	2	294	711	981
+896	PF04433	SWIRM		SWIRM domain	Aravind L	anon	Aravind L	Domain	This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins.  It contains a helix-turn helix motif and binds to DNA [1].	26.10	26.10	26.10	26.20	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.82	0.72	-3.86	79	1274	2009-01-15 18:05:59	2003-04-07 12:59:11	12	43	286	28	857	1242	5	86.30	27	11.90	CHANGED	hhhsshu...shhshs.plpphE..pphhschhh..................................ssp...sYlphRshllppa..phpssphLshoss..........+csht......Dsstlt+lapFLpcaGhINa	.....................h....shsshhsh..s...pl.pshE..pphhschhtt....................................................sPp....hYLshRshhl..pp..a.....phs..st.th..Lshsss..........+pslp.........DlstltRl.asFL-phGhINa...........	0	243	449	684
+897	PF00804	Syntaxin		Syntaxin	Bateman A	anon	Pfam-B_1158 (release 2.1)	Domain	Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins (Pfam:PF05739), and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A (Swiss:O35526) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role. The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors [6].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.23	0.72	-3.86	171	1633	2012-10-03 05:55:03	2003-04-07 12:59:11	20	15	425	9	971	1702	19	101.60	21	33.55	CHANGED	thspF.....hppspclppplpplppplp.clpphp....pphhshss..tp..................................phppclcplspplpp...hh.......pplppplc.........p......lppt..............................ttsssstphppsph.pslspcFpchh	........................................spFh.pp.spcIppplpp.lppplpclpphp...................pphlssss...sp......................................pphcpcl-pLstpIpp.ph................pplc..pplc.........................s...........................lppp......................p....................tppt.tspssssh+htpsp....hs.....sLupcFh-lh...................................................................................................................................................	0	281	496	740
+898	PF00907	T-box		T-box	Bateman A	anon	Pfam-B_363 (release 3.0)	Domain	The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations [2].	20.50	20.50	20.60	20.60	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.08	0.71	-4.81	22	2143	2012-10-03 00:25:27	2003-04-07 12:59:11	17	23	269	9	1083	1755	0	155.30	47	35.04	CHANGED	plpL-spcLWpcF+plsTEMIlTKoGRRMFPsh+lploG....LDPpuhYhlhlDhVPsDspRaK..assucWhsuGKAEPpsP.sRhYlHPDSPssGu+WM+pslSFpKlKLTNst...sssGp.l...lLpSMHKYpPRlHlVcs..ss..s..........ph.hpTasFPETpFIAVTAYQNpcITpLKIcpNPFAKGFRDs	...........................h.LptttLWtpFp........p..h..s..sEMIl..T.K.t.G...R.....R..........M....FPshchp..l..sG....Lc..s........pspYhl.hhD.h..lss..D...s.....p...R.......a+.............a..............p..s..u....p........W..h...s.....u...G...K.....A........-......st....h.......s...............s.R.....h...Y.............l....H..P....D...S...P...s...s...GtpW..........M+....p....l.SF.....pK..l..KL..........T...........N..............N....h.............s.....p....p......G........p....l.....................lLpS.h..HK.Y..pPR.l...Hllcs..sp..t..................................p.t.hpoasFs.ETpFhAVT..AYQNp..p................ITpLKI.cpNPFAKGFR-...............................................	0	218	311	758
+899	PF04719	TAFII28		hTAFII28-like protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4085 (release 7.5)	Family	The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex.  The conserved region is found at the C-terminal of most member proteins.  The crystal structure of hTAFII28 with hTAFII18 shows that this region is involved in the binding of these two subunits.  The conserved region contains four alpha helices and three loops arranged as in histone H3 [1,2].	18.90	18.90	18.90	19.70	18.50	18.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.85	0.72	-4.19	10	332	2012-10-10 12:36:46	2003-04-07 12:59:11	9	8	271	2	230	363	2	87.60	40	33.70	CHANGED	hQhLlosFocEQhsRYEsaRRSuhpKuslK+Llsp...lTG.polupsVlIulsGlAKVFVGElVEpAhcVpc..Epp-os.....PlpPcHlREuh+RL	............................tlLlssFoc-Qh.sRYEhaRRou..hsKu..slK+Llps.........ls.u.....p...SVspNVs..IshuGluKVFVGElVEc...........Ah.sVpc......cht..-ss.............................slpPp+h+cuhh......................................................	0	73	122	187
+900	PF04177	TAP42		TAP42-like family	Wood V, Finn RD	anon	Pfam-B_5735 (release 7.3);	Family	The TOR signalling pathway activates a cell-growth program in response to nutrients [1]. TIP41 (Pfam:PF04176) interacts with TAP42 and negatively regulates the TOR signaling pathway [2].	26.00	26.00	27.00	26.70	24.90	25.60	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.09	0.70	-5.49	39	389	2009-09-11 05:02:27	2003-04-07 12:59:11	7	7	295	3	263	396	3	308.00	25	90.82	CHANGED	sLpphFppuhphhs.plcp....ts..psosphQsplp...psIpphpcspphl.spLuLFSsNEslE-luTssLpYLhlsYaLupLhp+..................ssspRhphLptupphatpFLsphcsYc.llstp.tchhcph.............st.hs...shsssstpRptKIppaKpcKELcp+Lphlcpthpp.............................psD-E.............hRchaLspLphhhhcohppL-tlspElpl.Lpthtphttpst..........................................pphhc..............t.h...lsppspsLpPF.......hl..........hs.pRpphpppVFGsGas.LPTMol-Eah-pEhcpGthhcst......tpp.................ps.ppct.....c-cc.EpsDcEsh...+.sRpWD-aK-sNP	...................................................l.thattu.phht.tht.........t.s.u.thpp.t.lp...pslthhppstphl....splu.LFSsNEsl--luTssLpaLh.lsahlupLh.+..............................hs.spRhphLptup.......thhh......pF...LphhcpYp.l..ls.p....phhpph.............................t.......shsshstpRptKItpa+pp.Kc....l...cp+Lp.........tlcpthcp...............................................................psD.-E.....................hhRch..alhplphhhhp......uhppl-.lppEhph.Lpth.t....ttt.stpt.....................................................................................t.h.....tttstsl.p.sF...........hl......................pRpph..ptpVFt...sGas.LPTMol-Eah-pchcp....Gth.ptt........ttp......................tt.ppp..........p-pp.......-.......psDpcph.....+..sR...tWD-....aK-sp...............................	0	91	141	208
+901	PF03943	TAP_C		TAP C-terminal domain	Bateman A	anon	Bateman A	Domain	The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling [1]. The structure of the C-terminal domain is composed of four helices [1]. The structure is related to the UBA domain.	21.30	21.30	21.40	22.60	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.40	0.72	-4.54	8	365	2012-10-01 23:03:33	2003-04-07 12:59:11	8	19	218	4	263	372	0	49.80	36	8.36	CHANGED	QEMlpAhSsQSGMpl-WSpKCLpDNsWDYs+AupuFspLpscscIPtEAFt	......phltthoppouMshcaSppC.L.p.p.s.sW...saspA..hpsFp.plp....spspIPt-AF.......	0	74	111	185
+902	PF03134	TB2_DP1_HVA22		TB2/DP1, HVA22 family	Mifsud W	anon	Pfam-B_837 (release 6.5)	Family	This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein  (e.g. Swiss:Q00765), which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein (e.g. Swiss:Q07764), which is thought to be a regulatory protein.	27.20	27.20	27.40	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.26	0.72	-4.24	93	1350	2009-01-15 18:05:59	2003-04-07 12:59:11	14	26	310	0	844	1293	9	90.30	32	38.56	CHANGED	hshhupllss.lhGhlYPuYtShKAlcos...stp......-sppWLsYWllauhholhEhh.sshhlt.WlPhYahhKhhFllW......LhhP.pspGAphlYcphl+Phh	........................................................h.....phls.lhGhhYPu..YtShKAlcop.....shp........................-.ppW.lhYWllauh.h.ol.h..Ehh..s.......chh....l.......s..W.........h..P....hYa.hK..h.........hFllW......LhhP...tsp...G...uphlYcphl+Ph.................................	0	265	450	669
+903	PF00352	TBP		Transcription factor TFIID (or TATA-binding protein, TBP)	Finn RD	anon	Prosite	Domain	\N	22.90	22.90	23.10	23.00	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.62	0.72	-4.62	135	1985	2012-10-02 11:58:57	2003-04-07 12:59:11	16	8	584	132	1141	1872	373	83.40	38	62.81	CHANGED	tss.hpIpNlVAosslst.plcLcpl.uhph...css...-YcPE.pFPGLlaR....hp..cP...KsshL.IFsSGKlVlTGuKs.c-sppA.hcplhphLpchs	................................................................h..phplpNlV.uossl..........th..plc.Lcsl.Ahpt......ppu..........pYcP.......-....hF.su.l..I.hR.........hp....cP..................+....sshLIFsSGKlVhTG.AK.......s..cc-.sthA.hcphhtllpch.................	0	351	608	909
+904	PF03148	Tektin		Tektin family	Mifsud W	anon	Pfam-B_3069 (release 6.5)	Family	Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organised as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are  predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components [1].	25.10	25.10	25.20	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.31	0.70	-5.92	37	1118	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	349	0	335	991	0	261.70	40	82.81	CHANGED	WppsNhtphppupspRspuc+lpp-oppLhpEsptpTppsQpDssc+LspRlpDIphWKpELpcplcchtsEhstLtp.KpRlEcALpshp.hPlslsp-CLphR-pRhuh.DLV+DpVEpcLhKEl-lIcsspplLpcslppshcQlph.Rsu+ppLEhDhsDKhpAhpIDspChpL.sNsSsslpapssss+hs.......ssss..o.csWtcFoppNlp+Acp-ctsStpLRphl-plLppsusDlcsQtsssshAFppRlpEhpcA+scLchpLtcshpEIsptEcsIptLccAlp-KpuPlKVApTRL-sRot.RPNVELCRDpsQhtLlsEVpplpsolptLpp+LtpAcssLpsLhcpphpLEc-lthKpNSLhIDc.+ChphRpphss	............................................W+cNN..pYphospupccActLch.po++.hpcshsshshp.cDSs+K.LspR.............IcDlshWKcclp+slpslscEIspLcc...........sRs+LcsAhchLh.hP.uI.ucECLcL...........Rs..sRhcs...DLV.+D.-uEpEL.l..KE.Vslltpl++lhhsTL.s+s-EQh...h....hN....................+uAKpslEhDaSD..KhsuLcl.....Dc....cstsL......ssp..S.shl...a.+s...G.ssRhs.....................ps...so....o......E.......Wtcas....pt.........................................................................................................................................................................................................................................	0	101	127	224
+905	PF01397	Terpene_synth		Terpene synthase, N-terminal domain	Finn RD, Bateman A	anon	Pfam-B_728 (release 3.0)	Domain	It has been suggested that this gene family be designated tps (for terpene synthase) [1].  It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.	20.20	20.20	20.60	20.30	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.24	0.71	-4.91	141	1399	2009-09-17 01:05:38	2003-04-07 12:59:11	16	21	224	56	399	1601	0	164.00	29	30.94	CHANGED	WscpF.l..............sasst........cphhpplcpL.+pcV.+p.hl..s.sts.....phhppLpLIDslpRLGluaHFcpEIc.phLcplapp.htppp...tt...........DLassALtFRLLRpaGapVSsD.lFpcF.+-cpGp..Fpp.shh..sDs.+GlLsLYEAo.aLthcGE..s.lL-EAhs.FoppaLcphh...ttps..s.............L..spplppAL	................................................Wt..hh............tht............pphhphh.p.p.L..hpch.....pp.......hl..s..sh............shhppLphlDsl.....pRLGlshaFcpEIc.p.hLpp...la.pphtpps.........................DLh.ss.ALtFRLLRppG..a.p...V.........S..s..-......lFp.pF..pcppGp...Fp.........t....sh.........t.......pD.......s..cuhLsLYcAo.pl....t.h.p.uE..p..lL--Aht.FopphLcphht...p.p................LtpplphuL..............................................	1	37	241	326
+906	PF00440	TetR_N	tetR; 	Bacterial regulatory proteins, tetR family	Finn RD	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.07	0.72	-4.32	109	63222	2012-10-04 14:01:11	2003-04-07 12:59:11	18	89	4528	525	17576	49863	3840	46.40	26	22.51	CHANGED	IlpuAhclhs.ccGapssohpcIAcpAGlupuslYhaFs.uKcpLhtsl	....................llpuA.h.p.l.ht..p....p....G.....h....p....s...s..o.lpc....lAc..pA...G...l...s..p..u..s..l.Y.p.aF.....s..sKcsLh.t.....................	0	5211	11622	15040
+907	PF03850	Tfb4		Transcription factor Tfb4	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Domain	This family appears to be distantly related to the VWA domain.	21.00	21.00	22.10	22.10	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.08	0.70	-5.14	26	353	2012-10-10 16:07:06	2003-04-07 12:59:11	9	8	279	0	253	344	4	246.40	33	81.47	CHANGED	sSLLsllLDTNPptWsphppp.......hslopslsu........llVFlNAHLuhNpsNpVAVlAupsps.scaLYPssp...............tsspsshshst.st.............shY+tF+hV-Etlscclpplhppsstss.psp.....ohl.uGALohALsYINRh.p.spu..........................................pphpSRILl....lsuspDsshQYIPlMNsIFuAQ+hplPIDlspLsG..DusaLQQAuDsTsGlYl+.lsp.....scGLlQYLhhuFhsD.ptRshllLPspssVDFRAuCFC..H++llDlGaVCSVCLSIFCph..P........CsTCs	...................................................................sLLslllDssPhhW.t....ht..............................hslsphlts................lhsFhNuHLhhstsNplAl.lA.u.p...pt....spaLYPs.s............................................p...p.t....t................................shap.hp.hpphlhpplpplhp.p.sp.t.........t.t.....s.t...........ohl.uGuLuhALsaIsRh.p...h....t...............................................................thpuRILl........lps..up-ts.QYhsh.MN.s.lFuAQ+.....plsIDsshL.....ss.....sushLQQAschTsGlYlp..s.t.p.....................tu...LlQYLh....h...sF.h...s.......-.......p.....Rp....l.......h.h.........P..s........s.p......VDa...R..A..u.....CFC.Hcpll-lGaVCSlCLSIaCp.....s..........C.TCt...............................	1	84	138	210
+908	PF02269	TFIID-18kDa	TFIID-18; 	Transcription initiation factor IID, 18kD subunit	Bateman A, Mian N	anon	Pfam-B_3681 (release 5.2)	Family	This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold [1]	20.90	20.90	20.90	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.04	0.72	-4.17	6	572	2012-10-10 12:36:46	2003-04-07 12:59:11	11	6	281	2	396	577	1	87.00	33	36.04	CHANGED	phappElpsMMYuhGDspcPhsETssllE-lVps.lhElhppAhclup.cttpplplEDlhFLIR+D.tKlsRl+chLohp-hhpKstKphD-	....................h..att-lpphMauhGD.......s.......p.......p.......PhsETssllE-lVhp.lh...............-hhp.....p.A....tpl.....uppp......t.t.p.......p...l.psEDllFLlR..+..D...tKluRlcchLphp.-.hp+stKs.-t....................	0	122	205	319
+909	PF03847	TFIID_20kDa	TFIID_A; 	Transcription initiation factor TFIID subunit A	Griffiths-Jones SR	anon	PRODOM	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.07	0.72	-3.69	8	348	2012-10-10 12:36:46	2003-04-07 12:59:11	8	10	262	2	243	431	8	68.60	45	16.48	CHANGED	oK+KLp-LVppl.....DssspLDs-VE-lLL-IADDFV-SloshuCpLAKHRKScpLEs+DlpLHLERsaNh	...................sK++Lp-LV+pl................DssppLDs-.VEEh..LLplADDFl-sVsstAC.pLAKHR+Ss.....sLEl+DlQLaL....ERsaNh.................	1	81	131	200
+910	PF04494	TFIID_90kDa	TFIID_WDA; 	WD40 associated region in TFIID subunit	Bateman A, Wood V	anon	Pfam-B_9152 (release 7.5)	Family	This region, possibly a domain is found in subunits of transcription factor TFIID.  The function of this region is unknown.	20.60	20.60	21.20	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.59	0.71	-4.13	35	427	2012-10-02 14:46:49	2003-04-07 12:59:11	10	17	260	14	300	411	3	132.80	27	19.44	CHANGED	sp.hstttp-s..cPppYtpuYshL+sWl-soLDlYKsELp+.lLYPlFlasaL...-LlspshsppA+..pFasca+s-ap.hHsp-..lppLpslspspHlc-NphAptapssKYplplocsuasLLlpFLpcppss...llltllspals	...........................s........pssPtpYpptastL.+pal.cs.s...L.Dh.a+h.ELpp.l.LYPlFVahaL...cLVtsshtpcA+........pFap+..apspa.......tt....app-......lcpL.p.s..........lpp.p.c..........l..ppNph.h..p..tacssKahlplocsua.................phLhpaLpppppt....hlhtllppal...............................................	0	91	144	231
+911	PF04253	TFR_dimer		Transferrin receptor-like dimerisation domain	Bateman A	anon	Bateman A	Domain	This domain is involved in dimerisation of the transferrin receptor as shown in its crystal structure.	21.00	21.00	21.40	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.45	0.71	-4.55	36	850	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	269	58	560	820	42	119.80	23	16.83	CHANGED	slohp.lhpAhppapcsupphpphhcphc..........psshltl+h....h..NcplhplE+sFlss...hGlPs.+sha+HVlauPs.hs..ts........toFPultDultptp................WspspcQlsllshslpsAAstLtts	.................................................t.lshp.LhpAhtpappsupphpp.hhp.php.........................................pp.s.h.th+h......h.......Nc+.....lhh..lE+sFls........................tGl.P.s.Rsaa....+Hl.lau......Put.hsthss.................psFPulh-ulpptc......................hspspcplshhshslpsAAthL...s......................	0	150	267	427
+912	PF02824	TGS		TGS domain	Aravind L	anon	Aravind L	Family	The TGS domain is named after ThrRS, GTPase, and SpoT [1]. Interestingly, TGS domain was detected also at the amino terminus of the uridine kinase from the spirochaete Treponema pallidum (but not any other organism, including the related spirochaete Borrelia burgdorferi). TGS is a small domain that consists of ~50 amino acid residues and is predicted to possess a predominantly  beta-sheet structure. There is no direct information on the functions of the TGS domain, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, regulatory role [1]. 	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.68	0.72	-4.13	61	10557	2012-10-03 10:59:06	2003-04-07 12:59:11	16	41	4800	19	2820	7605	3711	61.10	35	9.24	CHANGED	ltlah.PcGphhc........ltpGuT.shDhAhtIHpslucphhhAhVsG.......p.hlslsphLcssDllcIls	.......................lhlho..PcGslhc................lspG.uT..slD...hA.h.sIH.s.s.lucpsluA+..VNG.......................................c.hVsLsp.Lp..sssplEIlT.......................................................	0	893	1705	2346
+913	PF00763	THF_DHG_CYH		Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_882 (release 2.1)	Family	\N	21.60	21.60	21.70	21.70	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.28	0.71	-4.06	105	5546	2009-01-15 18:05:59	2003-04-07 12:59:11	18	17	4681	28	1648	4097	2479	116.10	41	35.35	CHANGED	pllDG+tlAppl...ppcl+pclpplptp..sh.PpLulllVG-csASphYVcsKp+tspclGlcsphhplspshopp-LlshlpcLNpDsslcGIllQLPL..Ppplspp..pllpsIsPcKDVD	...........................................llDGKtlAp...pl...cpcl...tp...cV............pt..l..........pt...........p........s....hsPu...LA..VlLVGs...c.........P....A.SpsYVpsKp+us..cclGh.pS............phh..cL..........P...p...s.....s....o.............p........p.......EL.LshI.ccLNpD.s.slc.GILVQLPL.......P.pp......I..D...pp...pllpsIsPcKDVD..........................	0	523	1025	1369
+914	PF02882	THF_DHG_CYH_C		Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_882 (release 2.1)	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.02	0.71	-5.16	91	5651	2012-10-10 17:06:42	2003-04-07 12:59:11	14	24	4719	28	1679	4648	3203	157.80	45	48.31	CHANGED	HPhNlG+Lsts..ps....shhPCTPtGlhcLLcp.hsls...lpGKpsVVlGRSsIVG+PluhLLhp.........p........sATVTlsHSpT...csLsphs+pADIllsAsGpPphlpu-hl...KsGAlVIDVGINRl..........tss+.LsGDV-F-sltch.AuhITPVPGGVGPMTlAhLhpNTlpuAcpph	..................................................................................HPhNlG+Lhhs........ps....shhPC.TPtGlh.p.L...L..c.........c......h....s.l......c..............lpG+.p..AVVlGRSs...I.......VG..+PhuhLLLp........................t.....................s.A.TVTl..sH...op......T...................+s...L..tp..h........s...c.......p.......A.D.....Il.l...sAl.....G.+.......P.p..h........l........s..u...-.h...l..............K............G..A...l..VIDV.GlNRh.................................tsu+..LsGD..V..c.a.......-.s..s..tch..A..u.h.I..TPVP.GGVG.PMTlAhLlpNTlpAscp.h....................................................................................	0	539	1040	1395
+915	PF00899	ThiF	ThiF_family;	ThiF family	Finn RD, Bateman A	anon	Pfam-B_59 (release 3.0)	Family	This family contains a repeated domain in ubiquitin activating enzyme E1 and members of the bacterial ThiF/MoeB/HesA family.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.59	0.71	-4.34	90	12207	2012-10-10 17:06:42	2003-04-07 12:59:11	16	111	4208	117	4344	10198	2664	134.50	27	37.94	CHANGED	ppu+VlllGsGGlGuhssphLAts.Gl.....GpltllDtDpl-hSNLsRQhlaspsc..l...Gp..sKspsAppplpplNP.plp..lps....hsptl...................stpshppll.......t..sh..D.....lllDu........hDs..hssRhhlsp..hshpt.............th.P...hlpuush.shtups.hhh	............................pu+Vlll..Gh.G.G..lGu......ssphLA...t...u...G..l.........................Gpl..s..l............l..............Dh......D....s..V...c....ho.N.....L.pR....Q..h..l.h...........p.....p....s..s.....l....................Gp...........sK...s.........p.s.s..tc..p........l.......p............p..l......N.....P......p..l.p.......l.ps....hpp.tl............................................s.t..p..s..h...p..p...hh....................p...ph......D...............lV...l.D..s.................hD.s......h.p..s...+.....h...h...l..sp...hsht.t.......................p.h...P.....l.lpuush..uh.......hh...............................................................................................................................	2	1492	2600	3620
+916	PF02597	ThiS	DUF170;	ThiS family	Morett E, Mian N, Bateman A	anon	COG2104	Family	ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer Swiss:O32583. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS [1]. MoaD, Swiss:P30748 a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.42	0.72	-3.55	145	6781	2012-10-03 10:59:06	2003-04-07 12:59:11	15	34	3470	44	1951	4749	1939	72.90	24	84.19	CHANGED	lhh.uphpchss............tstTltpLlppL....s.hph.....................ptltltlNtchlpt.....sp.l..pcGDplsllPsVuGG	...................................................................hh.ut.tphhs...........................t.s...t..Tl.....t.pLlppL.....t.tpt..........................................ptl..t.lul.Np...p..hl..s.......p.................s.......p.......hl................p-GD......plsl..lssVuGG.......................................	0	625	1287	1677
+917	PF01833	TIG		IPT/TIG domain	Bateman A	anon	[1]	Domain	This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognise a significant number of members.	20.90	19.70	20.90	19.70	20.80	19.60	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.09	0.72	-3.99	131	8379	2012-10-03 16:25:20	2003-04-07 12:59:11	19	516	691	126	5044	7498	871	86.60	18	16.26	CHANGED	Pt.lssls..P...ttsssts.GstlolpG..psF........................tssssplhhusttsssh............hhssspl.................hspsPsts............su.shslplthss............tssshsapa	.................................P.lpslp.....P.......ppu...sh....t.....G...G....sp.......loI....pG......p.s...h..............................................................t.s.ss..h..p....V.....h.l......u..st...t...sssh...................................hhss.spl..........................................................hCps..Psts..........................su..th..p.l.plthss.............................................................................................................................	0	2483	3116	3961
+918	PF04280	Tim44		Tim44-like domain	TIGRFAMs, Finn RD, Bateman A	anon	TIGRFAMs (release 2.0);	Family	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane [1].  Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region [1].  This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast.  This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane [3].	29.60	29.60	29.60	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.54	0.71	-4.22	140	1637	2012-10-03 02:27:23	2003-04-07 12:59:11	10	10	1251	4	675	1440	1309	139.80	19	44.40	CHANGED	sutul.p.thpph-ssFssppFlpuA+stath.lhtAaspGDhcsL+shlop-hapthppslsp+.tptG..............shcsphlslpcsclhpuphc..sspshloVcFhsp.hth.hcpts.Gpll-G....s.spspchp-lWsFsRs......hsss.sssWpLsuhpp	..........................................................t.....t.hhths..ssFs....ptF..lptscphah..l.tA...a.s..p.s.-.........h....cs....l....+.p.hhotphas.thpt....tl...ppt..t.G.......................t.psp...l.tl.hps.c.l..spsphp.............sst..shlolp....h..p...h...h...h.t.t..s.....G.plhcG..........sts.ps....p.p......hp-lW..shsRs..........tst...tssWhlsshp......................................................................	0	200	377	531
+919	PF04176	TIP41		TIP41-like family 	Wood V, Finn RD	anon	Pfam-B_12821 (release 7.3);	Family	The TOR signalling pathway activates a cell-growth program in response to nutrients [1]. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway [2].	25.00	25.00	27.20	26.60	23.00	22.20	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.01	0.71	-5.03	29	320	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	281	0	224	312	3	175.30	40	57.53	CHANGED	MlFGcNhlpIpH.poGhsIcFNAhDALctVcppsp..sl+Vuhuc-WpcSRppsp.tp...........................-hlKPaDWTYTTsYpGTlhs...............ttthhhpsosccIslc+LpptDPILFaD-llLaEDELuDNGIShLSlKlRVMssphhLLhRFFLRVDsVLhRlpDTRlYh-Fsp......shllREapp+Essacplpp	.........................................................MlFGsNhlpl....pH...........tsGht..lpFNAhDALctV.......p...p....pt.......t..............l.+V..uhupcWp...poRppsp....t.t...............................cll.+PaD.WTYTTs.YpGTlts..................................................t.h...ph...p.sosp..pIsh-tL..p.pp.-.s....ILF.a--lhLaEDELsDNGlShLSVKlRVMP.s.s..hhLLhRFFLRlDsVLlRlpDTRlYh-Fsp...........shllREapt+Esphppl..p...........................................	0	72	123	186
+920	PF01582	TIR		TIR domain	Bateman A	anon	Pfam-B_571 (release 4.1)	Family	The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 (Swiss:Q99836) and TOLLIP (Toll interacting protein, Swiss:Q9H0E2). In turn, these associate with various kinases to set off signalling cascades [3].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.52	0.71	-4.74	45	4612	2012-10-02 18:56:14	2003-04-07 12:59:11	15	676	330	18	1819	5111	86	129.70	23	17.89	CHANGED	sFlsaps...........cscctFlsclhppLccp.....uhplalcp+.hhtGtphhss....lhpsIccS+hslllhScsaspSp..WC.LpELhphhcpthp.s..plllslFhpVcspclp.....pppscatpshtpthph.tsc.............tphthW+pshts	..................................................sFlsapt......................csp..ph.h.....h...s...cLh.....p....L...c...p.p.................s.h..p..l...h.l.c....c.+......-......h.........s..G....p.p..l...h.ss...............lh.p.u.I..c.........p.........S+...p.s.lh.VlS....ps....a.....sp.......Sp.............W..C...h..E..hh..h........h..h...p......p.............h..h...p...p......t.............t...p..l.l....l.h..l..h.....p.l..s.........p.plh...............tp.h.p.hh.h...thp...p.h....h....p...h.pp.....................tp....hWpphh..t................................................................................	0	512	992	1303
+921	PF03920	TLE_N	TLE_N-terminal; 	Groucho/TLE N-terminal Q-rich domain	Finn RD	anon	DOMO:DM01627;	Family	The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerisation.	24.00	24.00	25.20	24.00	23.60	21.00	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.83	0.71	-4.34	15	565	2009-09-11 00:33:27	2003-04-07 12:59:11	10	14	92	0	240	496	0	119.50	69	20.92	CHANGED	MaP..tsRhsuPtp..........suQP..FKFTluEoCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQuEIsKRLNAICAQllPaLSQEHQQQVsQAVERAKQVTMsELNulIG..........pQ.phQpLppt	......................................s.s..p..........suQs..hK.FTl.sEohDRIK-EFQF..LQAQ.YHSLKl..EC-KLAoEKTEMQRHYVMYYEM.S.YGLNIEM.HKQ.sEIsKRLNs.IhA....Q.llPFLSQ.E.HQQ.QV.sQAVE.RAK.QVTMsELNAIIG..................QQ..hQ.hQpLSp.t.................................	0	38	56	155
+922	PF05154	TM2		TM2 domain	Bateman A	anon	COG2314	Domain	This family is composed of a pair of transmembrane alpha helices connected by a short linker.  The function of this domain is unknown, however it occurs in a wide range or protein contexts.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.55	0.72	-3.75	142	3044	2009-01-15 18:05:59	2003-04-07 12:59:11	11	50	1798	0	887	2110	350	53.80	28	26.67	CHANGED	pt+shhhAhlL.sl..h..LG.hhGlHRFYlG..phtp.GllhLlhh........Gh.hsl........h.hlsh.l	.......................pshhh.uhlL..ul...h..........lG..h...h....Glc+FYhG...phtp.Glla.Llhhh.................Gh.hsl...................hhllp..h..................................................	0	311	541	742
+923	PF03348	Serinc	TMS_TDE; 	Serine incorporator (Serinc)	Mifsud W, Mistry J	anon	Pfam-B_3473 (release 6.5)	Family	This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid [3].  Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis [3].	20.30	20.30	20.40	20.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.65	0.70	-5.77	45	847	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	289	0	501	781	10	343.80	29	92.34	CHANGED	usCCGu...usCshhCosCsus...psShsTRlhYAhlLLlsollShIMlsshh.ppLp+.h.tas....................thsC....sp......hhGahAVaRlsFuluhFahlhullhlsV+SS+DsRAslQNGFWhhKhlhhlulhVsuFa.IPs.shFhhhhhaluhhGuhlFILlQLlLLVDFAHsWuEshlp+hE........-ssS....+hWhshLlssThhhYhsSlshslLhYlaas...ssuCshNphhIolNLllslllSllSlpPpVQEhpP+SGLLQuShlolYssYLTaSAloscP....D+pCNPh.............................hpspsshssshllGhllhhls.....lh.YoohRuussop....................................sshltLssc..............p.sh.p.cspshptssc-Gs.spps.......................hDsEcsuspYsYShFHhlFhLAohYlhhhLT.....................sWapP..tp.h...lsps.asusWVKIsSSWlChhLYhWTLVAPllhP-R.F	...............................................................................h.t...h..........psh...sRhh..Yshhhh.hsshlshlhht...h..h.t.l.....c.....h....h...................................................................................sC........t.........hhGh.uVaRls...huhsh.....Fah.........lhslh.h..ltlp..ss.......p.ss.R..u..t.lpN.G.aW.hhKhhhhhshhhhsFh.l........Pp...t.a..........h.........hh.hhluhhGu.hhFlllQLlLll-FAHpW..scthhtphc................pt..............phWhhhLhhsThhhY...h..h..uhsh.hs....lhaha..a......s..........................ts...Ct....Nphhls...hshhls.hhhohlul.P.......t...lp........t....P.p...........uGLh.Q..uuhlshYshYL..sa.SAhsspP.....pptCss...............................................................................t...tt....sh...llGhhlhhhs......lh.as..s.hps.uspst.............................................................................................tt........ts...............................tsE.pps.s.YsYuh.FH.h...hhhLA.ohalhhhLT..........................sW.....hp....................sp.....ht...ht..ts....h.shWVKl..s..ssWhshhlYh.WoLlAPh.h.h..pR.........................................................	0	149	252	373
+924	PF03459	TOBE		TOBE domain	Yeats C	anon	Yeats C	Domain	The TOBE domain [1] (Transport-associated OB) always occurs  as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately  after the ATPase domain.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.78	0.72	-3.86	81	5980	2012-10-03 20:18:02	2003-04-07 12:59:11	12	16	2667	79	1494	5716	620	62.60	25	27.64	CHANGED	suspNhltupVtslcttu...sps.Vplplusst....lsuplot...pussp..ht.Gpplhshl+sspltl	...................SsRNtltG...pl...s..s...l..pp....ss.........spscV..p..l..p..ls..ssp..............l.h.At.l..os........puspcL..tL...p.sG..pplhAhlKuspVh.........................	1	339	843	1182
+925	PF04265	TPK_B1_binding		Thiamin pyrophosphokinase, vitamin B1 binding domain	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1].	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.24	0.72	-4.26	86	1995	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1908	31	487	1399	315	67.10	24	29.30	CHANGED	Gp.ahlphppsh..................paluhlP..lssssp.lohpGhKYsL.......s.spshph..Gsh.hssSNch......tpp..splolpsuhsl	...................................t....lp..tsh..........................pYluhlP..ls.s.sp..lolpGhKYsL..............s.stshth..sss..hssSNEhh.....spp...splohpsGh....................	0	183	311	409
+926	PF04263	TPK_catalytic		Thiamin pyrophosphokinase, catalytic domain	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	Family of thiamin pyrophosphokinase (EC:2.7.6.2). Thiamin pyrophosphokinase (TPK) catalyses the transfer of a pyrophosphate group from ATP to vitamin B1 (thiamin) to form the coenzyme thiamin pyrophosphate (TPP). Thus, TPK is important for the formation of a coenzyme required for central metabolic functions. The structure of thiamin pyrophosphokinase suggest that the enzyme may operate by a mechanism of pyrophosphoryl transfer similar to those described for pyrophosphokinases functioning in nucleotide biosynthesis [1].	30.70	30.70	30.80	30.70	30.60	30.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.54	16	2336	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	2211	33	581	1714	474	120.30	26	51.60	CHANGED	N.p..thPt..hhps...ppschhl.usDuGusph...hth.......................slhPchhlGDFDSlsc.Ehhshhtpt...sphlhhs..-KDpTDh-hAlphs.......hphsts.clslhGuhGG.RhDHhh.......uslthLh..+h........s..hpshplhlhsp	........................................................................................ht......................pp....s..h.hl.usDtGu.hl...hch..................................................................slh...Ps..hhlG.D.....FDS.lsp..-..h.ph.h......tpp..........ht.p..h.h..h...s....-K...D..pTDhplAlphs.......................................hp.h.s...s...p..lh...lhG...A..hG...G..RlDHhl.......uNl.lhh..p...........................................................................	0	229	386	496
+927	PF00515	TPR_1	TPR;	Tetratricopeptide repeat	SMART	anon	Alignment kindly provided by SMART	Repeat	\N	22.90	13.00	22.90	13.00	22.80	12.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.34	0.73	-7.61	0.73	-4.14	555	18473	2012-10-11 20:00:58	2003-04-07 12:59:11	23	4566	3183	236	9338	112617	30616	31.90	20	6.62	CHANGED	spshhshGhsahphscaccAlpsapcAlplsPsp	.......................hhhphG.h.s.a..h..p....h....s.....c.......a.p...pA.l..p.sap.cAlphp.......................	0	3602	5574	7522
+928	PF01938	TRAM	DUF90;	TRAM domain	L Aravind, Bateman A	anon	L Aravind	Domain	This small domain has no known function. However it may perform a nucleic acid binding role (Bateman A. unpublished observation).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.89	0.72	-4.18	30	8506	2012-10-03 20:18:02	2003-04-07 12:59:11	15	36	4435	5	2131	6354	2315	60.00	24	13.59	CHANGED	pphlGpphcVllcshu...ppGpshu+spt............sphlhlpss....ts...G-hVcl+lpcspp..phLpGcll	.............................sphhp.lh.l.cshu..............ptGp....h..l...G+..sc.....................................spsV..hlpus.........................hs....GchV....cVcIsc..spp..p.hhucl...................	0	721	1386	1802
+929	PF00486	Trans_reg_C	trans_reg_C; 	Transcriptional regulatory protein, C terminal	Finn RD	anon	Pfam-B_94 (release 1.0)	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.37	0.72	-4.06	362	52522	2012-10-04 14:01:11	2003-04-07 12:59:11	23	271	4715	43	11355	34159	7239	75.80	30	29.75	CHANGED	spp........lpL.ospEapLLphLhppssc.lloRcpLhc..plWstsh........ssspsl-lalppLRcKlcs....s.ts................phIpTl+GhGYph	..................................p...lpL.T.s.p.Eap.LL.t...hL.h....p.....p..s.......s....c......lloRcpLh...c..........pl....W.s.hsh...............sssp..s..l.-VaI..p+LRcKlpp.......s.ts................................ph.Ip.Tl.+.G.hGYph..........................................	0	3440	7162	9460
+930	PF02458	Transferase		Transferase family	Bateman A	anon	Pfam-B_1540 (release 5.4)	Family	This family includes a number of transferase enzymes. These include anthranilate N-hydroxycinnamoyl/benzoyltransferase that catalyses the first committed reaction of phytoalexin biosynthesis [1]. Deacetylvindoline 4-O-acetyltransferase EC:2.3.1.107 catalyses the last step in vindoline biosynthesis is also a member of this family [2]. The motif HXXXD is probably part of the active site. The family also includes trichothecene 3-O-acetyltransferase.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.32	0.70	-6.04	11	3130	2012-10-02 12:01:53	2003-04-07 12:59:11	10	37	323	17	1766	3103	5	327.00	17	84.89	CHANGED	hpVphpppplIpPupPTPpp...pL.LShlD..hltssh.hs.shaFYcpssphspph........shcpL+puLScTLstYYPhAGRL.....sschplsCNs-G..s.FVEApucsp.Lp-hhch...sssshphllsphssspps.s...hPLhhlQlTpFcCG.GlslGhshsHplsDuhShspFhpsWAchu+ut...t.sssPsas+phlhsp........tsPps....hs.h......hssspptsscchlpKphsat....pssplccLpp+ussppsss...........................TphEsloAhlWRshsputptssppp.......sslhhslshRsRls.P.LssuYhGNshhsssstpss..u-l.pp.lshssctlpctlpp.lsc-hhpsshshsts.........hhhpthscsshh..ssalloSWs.+hPhh-lDFGWGpPlassssssshtsts....hhhPsp....tsssGltlhlsLspppMstFccchphh	.......................................................................................................................................................................................................................................h...........................................................................ht.tu.ht.h.L......a.....h..sGph...............................................................................l................................s...t.......u..............h......h.h.............s.......................................h....t........h.................................................................................................................h...............................................................................s....lh.h.......hQ.l..o.....h........t.s.........G.....u..........h.hluhthp..H.......hh.h.Duh..uhht....Fh..psh.u....p.h.s....ps........................................s............h....p....p...t........h..................................................................................................................................................................t......................................t.....................h.....h.h.........................p.......t.l.t.....t........h..t....t...t.....h.......t....t...................................................................................oshps.l...sAh.l....W..p....s...h......s.....t...u...h....t....h...........t..t.............................sthh.h...shs.....h....R.....t....p.....h........t......s...............l.....s.........t......s......a.h.........G.....N........h.h......h........h....s........h...s....h.ts..................tp.l.......h......t.........t..........s..........l..t...............h.......s....t....h.l..p.....p...t.....h..t.......t..........h.....p.....t......t...h..h..p..t..h...h..p.hht..............................h..........h.........................h....h...h..s.s.........p..h..s......h...h..p..h..D...F..G...........h...........G.............p.............s......h.h...t...........................................hh.......................tt..t......h...h...h...h.....................h.....................................................................................................................................................	0	148	963	1430
+931	PF01336	tRNA_anti-codon	Aspartyl_tRNA_N; tRNA_anti;	OB-fold nucleic acid binding domain	Bateman A, Mian N, Finn RD	anon	[4]	Domain	This family contains OB-fold domains that bind to nucleic acids [4]. The family includes the anti-codon binding domain of lysyl,  aspartyl, and asparaginyl -tRNA synthetases (See Pfam:PF00152). Aminoacyl-tRNA synthetases catalyse the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a heterotrimeric complex, that contains a subunit in this family [2,3]. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.29	0.72	-4.12	640	22969	2012-10-03 20:18:02	2003-04-07 12:59:11	20	145	5024	111	6345	20485	6498	80.20	20	12.26	CHANGED	lplt.Ghlpsh.................+st.sthhalp.....lpDts...G......plplhhhp......................tthhphtpplp......sshltlp..Gplptp..........tts..........................hplhspp......lphl	.............................................hpltGhlhpp................+st.up..h..h...F..ls...............l.p..Dts.....G........................tlQlhhhs.............................................tthhp.h.t.p..p..lp..........ts..s.h.lt......lp...Gpl.ppp.............pts...............................lplhspp...lp.....................................................	0	2125	3961	5336
+932	PF01841	Transglut_core		Transglutaminase-like superfamily	Bateman A	anon	[1]	Family	This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase, the human blood clotting factor XIIIa' [1]. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase [2], it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease. [3]	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.81	0.71	-3.86	87	6914	2012-10-10 12:56:15	2003-04-07 12:59:11	14	194	2577	45	2597	6853	1021	111.30	20	20.05	CHANGED	pphuppl......tstpssh..ptsptlhpalp.......pphpYs............hssssts........stphLt......spp.....G.pCtpaAslhsshhRuhGI.PARhlsGhhh.......s........................................sts.ss....................HuWsE....sah................shu.....WlshDs	....................................................................h...................s.h.....pth.h.t.lhphlt...............pp.h.pYs.........................t.s...sps......................stpsLt........ppp...........G...sC.psaAtlh.hs.hh.R.s.h.Gl...P...A...R..h.V.s.Gahh.............s...............................................................t....sh.....................................................................HuWs-l.ah................................s.ts......WhhhDs...................................................................................................................	0	827	1630	2120
+933	PF00927	Transglut_C	1005; Transglutamin_C; 	Transglutaminase family, C-terminal ig like domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1005 (release 3.0)	Domain	\N	26.60	26.60	26.60	26.70	26.50	26.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.28	0.72	-4.01	41	1042	2012-10-03 16:25:20	2003-04-07 12:59:11	17	15	108	79	564	1010	0	100.00	19	25.81	CHANGED	sphplclhssss.hupchsltlphpNshspshpsh....sshslphsGlhh..ptppcphthsltPtpptphplphh.pchG..pphlsp...hppspltcVpuhtplhlpp	...........................thplcl..s.s.sh.lGpchslplphpN............shsps.ps.....sshslphs.........Glhh..phhp...........pthhssltPtpptphph...plhspch...pphlsp...hp.sth.t.plpshtplhh............................	0	94	147	303
+934	PF02779	Transket_pyr	transketolaseD2; transket_pyr; 	Transketolase, pyrimidine binding domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.96	0.71	-4.78	93	20295	2012-10-02 16:07:47	2003-04-07 12:59:11	19	58	5038	173	5571	15647	10577	175.70	23	29.45	CHANGED	pthshppu.spAlsplhpcs.pllshutDls................sushsttpuhhp.p.......................RhhcsslsEpuhsuhssGhAhpG...hhsatupFhsFss......hspstlp.htuhtphsss.lss+sshGhGtcGPsHpuhc.huhhpslPs........................hpVhtPssss-stthlptAlp....tt.tPshlhhs+p.ht.t	.....................................................t..hshppu..spu.l......sph......h......p......p..s......s........p......l......hs..hutDlu...................su..s.h..t...t...p...p...u...h.tt...p........................................Rhh..cs.sluEtu....h..s.u...h..us.GhA..hp........G..............hhsht.upF.hs.F..hp.............hsps.t.l.t......h....t........u.h...h....p..h....s..ss....lhs+...s.s.h.u.h...G..t...c....G..s...s.H...pu.h..........p...huh..l..pt.h..P..s.......................................................................................hpVh..tPu...sss..-stthlpt...........ul.....p.....................p..s......P..s.hlhhs+p.h.....................................................................................	0	1847	3551	4709
+935	PF02780	Transketolase_C	transketolaseD3; transketolase_C;	Transketolase, C-terminal domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2].	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.45	0.71	-4.19	80	17209	2009-09-13 15:57:48	2003-04-07 12:59:11	15	48	4995	153	4660	13131	6413	117.50	22	22.65	CHANGED	Gcuplh...+pGp-lslluhGshlphulpAAcpLtpp.....GlsscVlDhRolpPlDhcsl...hptsc..+ss+ll..lVcEuhh.huGhuutlsshlsc.psht.h.sslhplss...-sshshs...thththhshs..ppl	........................s.h.....ppu..s.-..lsllu.hG.s.h...l.ph.A.lp.AA.cpLptp.................Gh.ps.pll..ch.Rslp..P..h...D..t...-.h...l...hp.t.c...cs.t..+.h.l.........llp.-....s....s...h...p..s....u.....l...u.....u.....tl.st.hh.........t....c..........sh....t.............h.........h...s...........l..t..p...h....uh.....s.s..hs.........hht.hshs.tt...................................................................	0	1573	3034	3963
+936	PF00335	Tetraspannin	transmembrane4; 	Tetraspanin family	Bateman A, Finn RD	anon	Bateman A & Pfam-B_3109 (Release 7.5)	Family	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.90	0.70	-5.07	212	4340	2012-10-02 01:14:40	2003-04-07 12:59:11	15	37	310	4	2488	3981	12	207.50	17	82.23	CHANGED	hlKhh....lh.hhN..hlhhlsG.hsllu......hGlhh...........................................tthhhs..s........hhllh.lGsll.hll.uhhGs.hG.uh.......+csp..........shLhhahh.hlhllhlhplssulhshshpsphpsthtp.h........................................................................tthppssshppthstlp...pphp.C.CGhpshp-atp.......................................................................................................sstssssshhppGChptlt...phlp.pp..hhhl......sslulsl....s.hlplluhlhuhh.Ltpph	....................................................................................phh.....hh.hhN..hlh..h........lhG...hhllu...hGlah....h.......................................................................t................h..h.h..s.s..h...lllh..h.Gslh.hll..uhhGs..hG..uh....................pc.sp......................shL...hh...........ahh....hlh..l..l.h......l..h.....p.l.s..s.u.lh.s..h...h...h..p...s..p.hppthtp.h...................................................................................tht...p..p..t.t..h..p.ph...hshlQ...............pphp..C....CG..h....p....s.....p..Da......t..........................................................................................................................................................................................................................................................................t..t.......t..t..t.t.....h....h..p..p...G.Chtt.l...........phhp...pp....hhhl..............shhshsl...h.h..h..p....l..hshhhuhh.h....h......................................................................................................................................................	0	761	1047	1771
+937	PF00905	Transpeptidase		Penicillin binding protein transpeptidase domain	Bateman A, Finn RD	anon	Bateman A & Pfam-B_726 (Release 8.0)	Domain	The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.70	0.70	-5.40	42	25088	2012-10-02 21:13:33	2003-04-07 12:59:11	17	55	4539	218	4622	19829	10300	286.30	21	43.58	CHANGED	ussVlh-s+oGplLuhsspsphsspp...........................hhtt.apPGSThKshss.hhul-sGhhpsppthpt.st.h..sstshpsapps........hshppuhppSsNhhh.pl.shclGtc..................p..htphhpphGhGspss.sh.tp..t...............................................hstsssuaGpu.lsloPlp.sphhsslsssG.h....hht........................t.....chshstpshpplpphhttsspss..................shpluuKTGTAphht.ts.h.............huhalGa.s.tsssphshslhls.......tssttsutssstlhpplhp	........................................................................................shlsh-spoGpllAhsu.s...s.a.ssst......................................................................................h..N.p.s.......h.......p......s.......h.......h........p....PGSohKshsh...ss..A..........l..........-..........p.........G............h................h...........s..............s.......s..........s..............h.............h............s.............s.........s..........s..............h.........h....................h............s.........s..........t.......p......h.......p.......s....astp...........................htG......l.s....hpp.......A....lt....p..S..sN....s....s....hs...p.l....s....t....p..l....G.h..s.......................................p......h.t.p.h.h....p.c.......h.G...h...s........p.......t....s...t..................................................................................................................................................................................................phhs.h.u.h....G....t.........G........h...sso......P..l.phup.sauslAN........s.Ghh.h..........p.......P..p...h.l.p....p...l....t.....p.sp.h...........................................................p................s...p....p...s....h....s...p....p....s..s..t..h.....l.p.p.....h.........h....pt..Vspps............................st...th..t....h.........s...h......p......l....u...G....KTG.Tu....p........h...................................................shh..sGa...................................s...........P.....p....h.s.h.s.lhht....................t..s....t........h....................................................................................................................................................	0	1494	3005	3893
+938	PF01609	DDE_Tnp_1	Transposase_11;	Transposase DDE domain	Bateman A	anon	Pfam-B_1013 (release 4.1)	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction [3]. This family contains transposases for  IS4 Swiss:P03835 [1],  IS421 Swiss:P11901 [2], IS5377 Swiss:Q45620, IS427 [4], IS402 [5], IS1355 Swiss:O69604, IS5, which was original isolated in bacteriophage lambda [6].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.43	0.70	-4.79	91	12598	2012-10-03 01:22:09	2003-04-07 12:59:11	16	50	2656	6	2783	18569	2527	188.80	13	58.95	CHANGED	ttttphh......hlDuohlpss..........................................tth..thpstpthtuh.Khclhs.....sssshhhshtls.sush.pDtphhtp..lhct..............phthlhuDtGYsstp....hhpplppp.shph..hht....h+tstth..................................................................................................hhtpptpthth..............................hhptRhtlEpsFphlKph.hthsc..hptpshsphpshlhht.hlshhl	..................................................................................................................................................................................................................................................tt........hD...h...........................................................................................................................................................th...t......h.phhh....................tp....t.h....h..tht.h........h.....ss....ph...p..-..h..p....hh.t........llpt.................................p.t.t.h..l.h.s..D.........tu..at.s.tt.........hhp..t.l...p....p......t....t...hph..........hh......................h+.t.p.tth..................................................................................................................................................................................................................................................................................................................h....h...t.....t.....t....t.....t....................h.......................................................................................................hh.p.t.R.h.t.l..E.t..h...ap.h...+...p.......ht.h.pp......h..t.p....t..t.thp...hhhh.hhh.......................................................................................................................................................	0	850	1859	2290
+939	PF02371	Transposase_20	Transposase_19; 	Transposase IS116/IS110/IS902 family	Bateman A	anon	Pfam-B_280 (release 5.2)	Family	Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS116, IS110 and IS902. This region is often found with Pfam:PF01548. The exact function of this region is uncertain. This family contains a HHH motif suggesting a DNA-binding function.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.69	0.72	-3.88	139	6999	2012-10-03 02:11:09	2003-04-07 12:59:11	11	25	2087	0	1815	6255	787	83.60	27	26.97	CHANGED	sphLtolPGlG.lsAssllupl.s-h.pp.FpsscplsuasGLsPttppSGsptp.ps+lo+.tGsptlRphLhhuA.hssh.ph.......s..shhpthap	............................hltolPGl..G....h.sA.ssllu..........pl..u-h..pp..Fp.sscp..lsua.s.........GL.sPtp.h.pSG..sppt...ttphoK..tG.sptLRphLh..sA..hssh...ph.............p....................................................	0	542	1135	1449
+940	PF01526	DDE_Tnp_Tn3	Transposase_7;	Tn3 transposase DDE domain	Bateman A	anon	Pfam-B_885 (release 4.0)	Domain	This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli.  The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases [2].	20.70	20.70	20.70	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.91	0.70	-5.86	50	1929	2009-09-11 04:42:20	2003-04-07 12:59:11	12	14	851	0	316	1636	192	297.90	33	44.98	CHANGED	DlLh-VsphTuFsptFpclpst.....chpsttptllAsllA.GsNlGlpchAct.ssslohcpLshspppalct-slppApspllstppplsluphW..G...s.Gp...s..u...SSDGp+assstpsltu.phss+Yt...stGlshYsalu-passhauplIssstpEAhallDGLLppp..os.l...pscp..hh..sDTtGho-hlFulhcLLGapFsPRl+slp...c..p...+Laph...c..s..ss.pYsplssl.h..tp....pIshclIcppW--llRlssSl+tGplsuotll++Luuh.s+pssLtpAlpElGRl.+TlFlLcYls..-.slRRplpttLN+uEuhpsLsRAla.aGptGclps+sh-pQphpssuLsLlsNuIlhWNThalpcslpplcpp.G..pls.s...chltclSPlsapHINhhGcY	.........................-llhtlst.s.tF.pthhthptt........t.t....lhsslh.u.uhNhGhp.hsp......ssh.shtpLt.htt.hhp..cshptA.s...lhph..ph....hsthW..G...t.up...hu...ouDG..ph.s.....ps...s.t.s.+Yh.....t........GhhhYphlscp.assh....s...................hlsss.p-uhall-Gll.p..p.....os...l...p.pp..hhsDTtG..................hochsFuhhtLLGaphsPRltshtp...p...phah......p..t........st..th..t.lt.h..h....tt....plsh.phIttpas-hhRlssSlp.Gpsssshhl++Lss..sptstlh.AlhEhGRl.+TlahLcalp...s.phRRplpttLN+GEuhpultRslh.as.ph.Gc.lpp+thcpQp.phssLsLlssullh.WNThhhppshpthp.....tp.G...hs.t.phlttlSPltapHI.NhhGcY..............................	0	61	182	248
+941	PF01548	DEDD_Tnp_IS110	Transposase_9;	Transposase	Bashton M, Bateman A	anon	Pfam-B_646 (release 4.0)	Family	Transposase proteins are necessary for efficient DNA transposition.  This family includes an amino-terminal region of the pilin gene inverting protein (PIVML) and members of the IS111A/IS1328/IS1533 family of transposases.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.69	0.71	-4.53	127	7132	2009-09-14 00:11:16	2003-04-07 12:59:11	12	28	2092	0	1856	6395	788	129.20	22	42.24	CHANGED	hlGlDluKpphpls....hhssss............htptphsss.tuh.pplhshlpph...t..............hhlshEusu.htt.hltphLpp.tGhpVhllsstps+shtp....ptsKoDthDAphlAchspp..t...php....h.......htstptppLptLsptRcpLhpppsphpNc	.............................................lGlDlu.K.p.phpss....hhstps..........hh.h.p.t.p.h.s.s.s....ts...h....pplh.phltph..t...................hhls.hEusuhht.....h.......h......h......p......h......L......p.p....h........G......h......p......l..hl..l.s.Pthh+tht............ptsKoDthD...Ath.l..A..chhpp.........t.....php........h.......h.st.t..ptlpt.Lh....p....h....+p.plhpphst.hs..................................................	0	549	1162	1475
+942	PF00579	tRNA-synt_1b		tRNA synthetases class I (W and Y)	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.88	0.70	-5.29	40	11971	2012-10-02 18:00:56	2003-04-07 12:59:11	20	46	5006	203	3414	8921	6461	279.10	24	74.98	CHANGED	pp.tt.hplhsGhcPTus.lHlG.ahsslpphhphQ......tGacshhlluDhpAhhscss.....cplhpppphhtss......L.uph.lDsp+...............sp...lhhpSchhpph..phthhlpplushhpls+Mhphcs......hppchpp..............slshuthsYPlLQuhDhhhhpsc....l..sGsDQptplphuc-lsc+hspp...................hshslhss....llstssGp..KMSKStss...sIaLscptpsshchhpphhssscp..tltthhthhshlss..............lphhpth...ttpss......pthcclhsphhsthhpsschtptstpshpphhp	.....................................................................hp......tlhsG..hcP.T.us..LHlG.alssl.hp.h.....h.p.h.Q....................ss...a..c..s..h.......h..h..l...u...s.....h...puh.hsc.s.......cp.l...p..p.p.p.t...htss................l...uth....l..D......pc.........................................................................................sp.....lh....p..u.c...h....t.ph.......phh.h.h..l..p..s.hsp..h..hpls+M.hphcs..................h..tpchpp.........................tsl.s.h.s.F..sYPl....LQ..uh.....D.hh.....h..h..pss........................l..sGpDQh.tplphu..p-.....l.s.c...+.h.stt..............................................................................s...t.sl..hss.................ll.st...h......D.........G...............s......................KMS.K.St..ss................slhL.........s.p.........p..sshc.h.h.p..t.hhsss-t.........lh.h......hp.h..h...s......hs.............................................l.p...h...h.p.th......stps............hpc.lhs..p.h..s..t....h.....htstchtptstchhpthh......................................................................................................................	0	1164	2149	2869
+943	PF01409	tRNA-synt_2d		tRNA synthetases class II core domain (F)	Howe K	anon	swissprot	Domain	Other tRNA synthetase sub-families are too dissimilar to be included.  This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.61	0.70	-5.18	46	6642	2012-10-02 14:22:40	2003-04-07 12:59:11	15	27	5187	59	1844	6318	4237	222.30	45	68.66	CHANGED	slDlolP...upthtsGshHPlspsh-clpclFhthGFphhp.GsplEs-aaNF-ALNlPppHPAR-hpDTFal....p....................................s.phlLRTHTosVphRth.....pppc...sPl+llu.G+VaRpDs..DATHps.FHQlEGlllDc..slohucLKGsLcpFhpphFGtc.hclRFRPoaFPFTEPSsElDl.t.................tcpstWlElhGsGMl+PpVLcss.......Gls...pchsGhAaGlGlERlAML+YGlsDlRphaps..Dl+FLcpa	.......................................................................................................................................................................t.lDlohs.....sp..h.t...GthHPlsth.hcclpp...hF...h...t........h........G........a........plhp....G....s-lE..s............-aaNF-.sLN...hP.t.p.H.PA...Rs.h..p...D.TFYl............................................................................spphLLR..T..aT..S.s....V...Q...h...Rsh..................................ct...pp.......sP...l.+....h.IuP.G+V.YR...p.Ds...D...u...TH...os...FH........Q..l..EG....L...l...l.............D..c...................s..l........o...h.............u...c...L....K....G..s..L..c..t....hh+ph....F.........G.......p..........c....hp............lRh........R.P...SY.F...P....F.T.E.PSsElDlts..........................................t.ctssW.lE...l.LG.s.GMV+P.p.VL.c...s...........................GlD..sp.asGFA...FG.....hGh-RhsMl............+aslsDlR.haps..DlRFhpp.................................................................................................	2	623	1139	1548
+944	PF01588	tRNA_bind		Putative tRNA binding domain	Bashton M, Bateman A	anon	Pfam-B_482 (release 4.1)	Domain	This domain is found in prokaryotic methionyl-tRNA synthetases,  prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding  protein (G4p1 or p42, ARC1) [2], human tyrosyl-tRNA synthetase [1], and endothelial-monocyte activating polypeptide II.  G4p1 binds specifically to tRNA form a complex with methionyl-tRNA  synthetases [2]. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme [2]. This domain may perform a common function in tRNA aminoacylation [1].	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.02	0.72	-4.15	43	10729	2012-10-03 20:18:02	2003-04-07 12:59:11	15	48	4863	53	2411	7871	3721	99.10	31	16.79	CHANGED	l+VGcllcsEcaPsADK.LhhhplDlGpcp.....RplVuGlsphhs..-th.s+hlllls.NLcPt..............KhRGlpSpGMlluAp.......sssp..htllssstss.sGsc	..............................................lhVGcll..ps..c..p..h.P..s.......u..DK......Lhhhpl.......D....l............G.......s..........c.........p...............hpI.Vs.Ghs.shhs..........cs....l...luphss.hls....N....hp.p..........................Kl.R....G..h....SpG.Mlhuspp...............sspp....s..l.l.ph.s..p.s.h..sGt..................................	0	822	1535	2024
+945	PF03250	Tropomodulin		Tropomodulin	Bateman A	anon	Pfam-B_3359 (release 6.5)	Family	Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments [1]. Limited proteolysis shows this protein is composed of two domains [2]. The amino terminal domain contains the tropomyosin binding function [2].	21.80	21.80	21.80	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.67	0.71	-4.68	12	463	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	101	0	230	395	0	130.10	40	31.99	CHANGED	Mu.s...hp+-LtcY+DlDEDElLtsLStEELcQL-htLpElDPENshLPAGhRQ+DQTpKsPTGPaDR-pLLcaLEKpAlEhKDR-DhVPF.TGEK+GKlFVPKp+stch..tcEploL-.P.ELEEALssATDsElCDlAAILGMaTLhssp	.....................ap+cLpc.Yc.D.lD.EDElLusLSsEELcpL-pEL--lDP-s..shLPsGhRQ+sQTpKsPTGsFsR-tLlpal..E.Kp.A....hchh.-+E-h..VPh....st.h.+.G.+....a..h.......................................t..................t.......h..tl-.....s.-.hcp..uLtpAspt-hh-lA.tlls................................................................................	0	29	46	105
+946	PF00992	Troponin		Troponin	Finn RD, Bateman A	anon	Pfam-B_62 (release 3.0)	Family	Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT).  The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I.  Troponin I binds to actin and troponin T binds to tropomyosin.	23.20	23.20	23.30	24.10	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-11.04	0.71	-4.09	56	1116	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	175	22	337	1073	1	125.00	33	53.51	CHANGED	K+pLKsLhhtpAtpcLcpEpcc+tpE+pphLp-+s.shp.hsu..sps-LQcl.s+ch+p+lspl-EERYDhEt+lsKpctEI--LphKl................hDL+GKFKKPsL++V+hossuhh+uhLGsKHpsshDLRusLKpVK	...................Kp..K.sLh.hpAh.-hchEpccKEEEc............hhhLp-.Rltthc......h...........ppu-...................Q..........cl.scc.+c+.s+l-..EE+h.chE.tc.t+pctE....cthppKs..........................t-h+t...hK+..sh+.ch+hph.u.h+t.Ls....c...+.h..s.p.pLRt...phKplh........................................................................	1	71	116	229
+947	PF00234	Tryp_alpha_amyl	tryp_alpha_amyl; 	Protease inhibitor/seed storage/LTP family	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This family is composed of trypsin-alpha amylase inhibitors, seed  storage proteins and lipid transfer proteins from plants.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.26	0.72	-11.45	0.72	-3.77	187	1632	2012-10-01 19:46:35	2003-04-07 12:59:11	17	6	243	52	214	4676	6	103.10	21	68.27	CHANGED	Cstshhp..............................lssChshhps..........spppCCstlpsl...................ttttChCtslpshhhs................................................................................tht..tsttLPshCsl....shP.........tC	..................................................................................hht........................................h....s..hshhp..t.t.hs................sl.ps.CCppLtsl....................sphCpC..tsltshhpuh..............................................................................................................................tt.ls..hh.sAs..slPuhCs.l..sls..........................................................................	0	29	95	159
+948	PF00089	Trypsin	trypsin;	Trypsin	Lutfiyya LL, Sonnhammer ELL	anon	SCOP and Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.76	0.70	-4.76	71	22248	2012-10-02 13:45:52	2003-04-07 12:59:11	21	596	2517	2044	9786	28849	4196	206.20	23	59.84	CHANGED	IlGGppsphtsh....Pa.sslphps...........hCGGsLlspp..all.TAuHChps..................phpl.....hhGt..thppppss......phhplpp..hhhp.tassps..............tDlALl+Lpps........hphssslpslsLss.....ss...tssspshlsGaGp...stpsu........sphLppsplsllspp.pCpp....h..................lssshlCsss........tt..ssCpGDSGGPllstst........lhGlsS....aG..hsCupsph....sula.spls....thhsWI	..........................................................................................................................................u.....s.....t.ph....Pa...s..t..l.......htt...................................hhC..G...G...s...l.......l........s..........p..........p.......a......l...L..T........A..A...H.C.hts......................................tthpl................hhG....t.............t....h....p....t......t......p.s.......................t...h..h..t..lpp.............hhh..H.....p....a.s..t...ts..h............................................tpD..l......A..L.l...c...L...pp.s..................................h.t....h...s...p....t....l...p.......s.....l..sLsp.....................t.t...........s...s.....p....t........s.......h......l....s...G..W..Gp.................s.t.tss..........................sp.hL...p..p...s..............p.l.......l.....l....s....p...p....t...Cpp............h.....................................................lp.p.s....h..lCuuh.............t................t...ts....s...C.................p..............G....D........S...........G....G.P...L....h...sptt...............................lhG.l..s..S.............aG........s....C.....s....t....h.................ula......splt......hh.Wl...................................................................................................................................................................................................	1	2699	3841	6981
+949	PF02210	Laminin_G_2	TSPN; TSP_N;	Laminin G domain	Finn RD	anon	Pfam-B_4211 (release 12.0) 	Domain	This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.64	0.71	-4.10	208	7915	2012-10-02 19:29:29	2003-04-07 12:59:11	19	1063	156	84	4277	8885	448	128.10	19	16.04	CHANGED	F+T...p.pssGlLlassstss...................taltlplp.sGp.lthphshu................tss.hhhhsspp..........l.sDGp.WHp..Vplppptpp................hplt.....VDsptstttttsttt...................................thphsss.lalGGh.spt.t................ppsFpGClpslplssp	......................................................F+T..tpss...G.lLlhssstps...............................talt.lp.l..........p..s......Gp....lt...hp.h.shu..................................ssshh.h.h.h.s...s.t.t......................l...s..D..G.p..WH..p.....Vp.l..p.....p...p..s.pp...........................................spLp..........V.D..s..pt...s...t..t...thts..ttt....................................................................tl.s.hpss...lalG............Gh..sp.t.........................................tpsFt.GClpslhhss.....................................................................................	0	870	1227	2700
+950	PF03133	TTL		Tubulin-tyrosine ligase family	Bateman A	anon	Pfam-B_682 (release 6.5)	Family	Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL) [2]. The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness [3]. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis [4].  Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent  dioxygenase domain [6].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.88	0.70	-5.49	21	2286	2012-10-10 13:17:02	2003-04-07 12:59:11	10	53	310	4	1558	2259	173	263.90	24	44.99	CHANGED	hphpp......tptlNaaPsshplspKD.hhhpslpc.tpphthc.......................hthhspoahlst-hsphhphapcppt............shWIlKPsupu+GpGIhlhschspl.............................................pppshllQ+YIc+PLLlss......pKFDlRhYVLlosh.pPLplYlYc-u.lhRFuopcYs........hsshpshhhHLTNhulpKc.t.....tpc.pthpspcaoltshhthhpp..hstcplhpplhshlhcshlsu.......hpsst.shppthssFElaGhDlhl........DpslcPWLlElNhSPsh.psssthssplpstllpslls.....lsssptpsh	................................................................................................hht............hsph..t...........l.spKt...hhhp..h.tp.h..t..h..p......................................................thhP..o.a....h.......s.....t.....c...h..t...............h..h...p........h.t..pttt......................................................................thWIh...KPs.s.....t...sp.G...p.G.........I..h..l..h...p.p.h..p.p.l..................................................................................................................ttpth.....ll....Q....cYI....pp.P.hL.lts.............................hKFD.l.RhY.lL.l..........s.....u.........h......p..P....L.p............la.h.a.........ccu.hsR........Fusp......Ys.......................ps..hp.s...hhh....HLT....N.hul.p+p.............................t..........t...................t............s.........p...p...h.s.....h.....p....p......h..........t......h.hpp.............h..p.....h.....p.....p.....h..h..p.p.....l....h....p..hhhp...hhlts...............................hpss.........h..............t...........p...s..F.ElhG......hDh.hl......................Dp.p.....h...c.....P.aL.lE..............l.N..hs.....Ps.h...t.t...s...s.....h...p.....h.p.l.h..thh.tshhp..............th................................................................	0	771	931	1276
+951	PF01167	Tub		Tub family	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.70	21.00	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-5.39	11	847	2012-10-02 20:44:47	2003-04-07 12:59:11	13	23	166	7	509	787	14	217.80	36	43.04	CHANGED	PAPpsshlpChIpRDKpGhD+GLaPsYahaL-p...EsG..hFLLAuRKRK+SpToNYlIShDPsclSRsussYlGKlRSNhLGTKFTlaDsGsssp+..sp................ospssshR.-LAsVsYEsNVLGa+GPR+MolIhPGhssssp.....RVssp...........................................Phs.sp-slLschpppst-slllL+NKsPpWs--sQsYsLNF+GRVTpASVKNFQllcs....................................scPDaIVLQFGRVucDhFTMDaRYPLsAhQAFAIsLSSFD	...........................................................................................................................pt....hpChlpR..s+p..s.........s.hh....h..a......h........h............cps.........hFLLuu.++h.++........s.t.p....spYlI.....Sh....s....s..s...s..h........S+....tu.........p...s..........a.......lGKl.R........S.N.h..hGTcFhlaDst.s.tt..t..........................................................p....s..th.p..plutl.Y.c.h..Nl.L...s.......+.G...P..R+.Mp..shh....s.hs.pt............h..hp....................................................................................................s....tt......t......s....h...t.....p..h.p..p.....p....s..hp.......phl....LpNKsPhWs-phQ..sasLNF.+........G..R...V......T.....ASVKNFQl.lts..........................................................................................................................................................s-..-.h....l.lh...QFG+l..u.............c..D.hFThDa....p.YP.lsAhQAFAIsLoSF-.............................................................................................	0	172	275	391
+952	PF03953	Tubulin_C	tubulin_C; 	Tubulin C-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.47	0.71	-4.09	66	8994	2012-10-03 12:11:42	2003-04-07 12:59:11	12	31	3147	105	2212	7432	55	113.00	52	32.23	CHANGED	PRlHFhhsuaAPLsups.....ptsacphoV.-lTpphF-spNhMs...ssDP+p........G+Ylosss.laRGcVss+-Vccsltplps+ps..spFV-WhPsulKsulsshsPhshptu........ushluNoTuIpclFpRlsc	...............................................PRLHFhhsGaAPLoScu....................uppa.Ru.loVs.E..LTp.Qh..................F.-...........s+.N.MMs.....us...D..PR.+..........G+Y....losss....ha....RG.......c...hs............K.-V.cc..p.h.hs..lps.........K.p.o.......s.F.V-.Wh.P.s.s..hK..........suls.....PPp...sl.hu..................sshluNo..TuItE..hapRls.c...................................	0	760	1134	1715
+953	PF00567	TUDOR		Tudor domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.37	0.71	-4.28	48	3295	2012-10-02 16:56:36	2003-04-07 12:59:11	19	92	277	31	2089	3372	6	118.30	19	26.42	CHANGED	hhhspthslhloplt.ssspFal.......tpstpplppltpplpphhpphtt.......ht.sthspsssshhstDs..pWaRApl.......tthsspphcVhalDYGspph.lshsclptls.pphtt........Ph.uhcspLss	..........................................................................h......pshlst.l...s...s..s...p..hah....................h.pp.t.pp....l....p.....p..........l.....p.p.l.p..p....hh.ppttt...................ht...p..h.sp.h.s.h....s...t.......h.....p....t......-.s.............pW.a.Ruhl....................t.hss.....p..p............s..pV....halD.a.Gspp......h...l...s...h......s...p......l......p..........l....s...p...p.hhp.....l...Ph.AhpspLt.....................................................	0	629	828	1457
+954	PF04906	Tweety		Tweety	Finn RD	anon	Pfam-B_5713 (release 7.6)	Family	The tweety (tty) gene has not been characterised at the protein level. However, it is thought to form a membrane protein with five potential membrane-spanning regions. A number of potential functions have been suggested in [1].	29.70	29.70	30.00	32.60	29.50	29.60	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.42	0.70	-6.06	14	332	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	97	0	157	301	0	341.60	35	69.90	CHANGED	applsusFpPcDt.sYQQSLlhLusluussLuLsLLhLhhYLlphCCsR+.pcspssp....csCClsWssllssLlC...........CAuIGlGFYGNuETsDGlhploYSLcpAN+TluGIcshVpsosssLppslcppLtpL--laus+s-.......alpslphhQp.sssllpphsulP..hWpts....slslsplAppsshhEaYRWLuYLhLLlLDLlICLlsllGLARpS+slLlshsshGlLsLllSWuShGL-hAsAVGsSDFCssPDsallp.sppphs..sDllpYYLhCu.utsNPFQQpLohup+uLssMQpplpsLL+.Als.FPsuc..csLlulQtlLNooEhsLHQLTALlDCRuLHhDYlpALpGlCYDGlEGLlaLsLFShluAlhFoshVCusP+sWphhtsR-cDh--hp-psPh	....................................................................................................................................................................................................................................t.p...h.puLh.hlus.l..uhh.sLsl.s.Llhlh...hYh...hhhC...Cp+p..p...ttpt....................tssChshs.h..l..hssLl.s...........s.sul...u..l..GFYGNuEss.DGl.plh.ulh....psNpTl.....s.slpp.......hl.ts.sttLp...ps.lc...tpLtpLpc...h..h...stp..s-............hltshphhpt.hpslhttht..sls.....hhpts......shs.h.tpl.....up.psshh-.......Y.R....Wl..ua.lhLL.l.ltll.....lCLh.s.llGl...........s........+...........pS+hhll...hhsh..hu...lL..sLl.lSWsuhGlc.hAsuV...uhSDFCssPDsalhphsppphs.......s-llp.YYhh.Cs.....s..hs.....N...P.F.Q.Q.p..Lo..sp.+...uLsph...ptplt.tL....p...uh........ass.sp.......csLhtlpthL..N....soEh......shpp.LsAl...l....cC...RuLHtDYh.pAlp.GlC.DulpGL.laL....h..L.aS...hlsAhhhsshlCshs..+sWt.h......p.p.p.tp........................................................................	0	39	56	101
+955	PF04564	U-box		U-box domain	Bateman A	anon	Pfam-B_2801 (release 7.5)	Domain	This domain is related to the Ring finger Pfam:PF00097 but lacks the zinc binding residues [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.36	0.72	-4.01	16	2544	2012-10-03 15:03:13	2003-04-07 12:59:11	10	170	360	21	1743	2959	196	70.60	32	11.07	CHANGED	lPDEFhDPIhhpLMpDPVlLPSG.hshDRusIp+HLhs......spoDPFs.RpsLTpcpLhPNhpLKpcIspalpp+cp	...........................hPpt.F......h..C....PIo.hcl......MpDP.V.l.......h...s...o.....G....hTY-..Rps.I.p.c.a.l.p.p................................s.p.osP.h....T...p.......p...........s..L...s..p.....p.........p..L....h.PN.hsL...+phIppahtpp..h................................	0	505	1047	1434
+956	PF00627	UBA		UBA/TS-N domain	Bateman A	anon	Bateman A	Domain	This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle [1]. This domain is found at the N terminus of EF-TS hence the name TS-N.  The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU [2]. The domain has been found in non EF-TS proteins such as alpha-NAC Swiss:P70670 and MJ0280 Swiss:Q57728 [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.47	0.72	-4.00	141	9566	2012-10-01 23:03:33	2003-04-07 12:59:11	26	206	4854	104	4154	7764	1831	37.30	34	8.50	CHANGED	hspptlppLhph..G...aspp.pspcAL.ptsss..sh-pAhphL	...............stphlcpLp-h...G....hshh.cs++AL..p.....p..ssG...cl-tAl-hL.............	0	1308	2242	3222
+957	PF01040	UbiA	CytC_assmbly_fac; COX10_ctaB_cyoE;	UbiA prenyltransferase family	Finn RD, Bateman A	anon	Pfam-B_1357 (release 3.0)	Family	\N	24.60	24.60	24.60	24.60	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.17	0.70	-5.17	138	10787	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	4280	0	3435	8227	6621	264.00	17	84.83	CHANGED	hhhsh...hssh..hu..hhhshtshhsh.........hhhhhhhshl............hhts.us.hh...N-..hhDhchDt.................tt..tp..........ls.sGtls....p.pshh.hshshhhlu..lh.....hu.............hhhs.hhhhhhshh..shhh..s.hhYo....................hh+phshhsplhhuls...hu......hhhh..hushh......hsth...............................sh.hhlhshh.hhhshslhht........thtDhcsD.ppsGhpo...........lshhh........t.thhh.......hhhhhsshhh...............hhhhhhhhhhhhhshhhhshslhh..h.h...........h.........................hhthhhhhhh	........................................................................h....hhssh.hu.......hhhu...t.s...h..sh...............hhh..hhhhlush.............lhtu.uussh...............Nc....hhD.t.chDtpht................................Rp..tpR..............s........ls..sGtlo...........p...puh...h...hshh.h.hl..lu....hh.....lh.................................hhhs...h...h...s...h....h......l......u.hh.....ulhh.....h..hhYo...........................hhK.+.hs.....h.....splh.suhs..........hu..........hssl..hGhss.........sssph......................................................shhhhl.hhhh.h.h..h....h....s....huhhhh....................................sht-.hcs.D.....tp....s...G.hto................lslhh...........Gtptshh...........................hhhhhhhhhhh...........................................................hh..h.h.hhh..h..s..h...h..h.h..h..h..s..h..h.h.....h.sh.h...h..h...h.......h...h...h...h..........p.....................................hhhhhhhhh..........................................................................................................	0	1089	2178	2911
+958	PF00240	ubiquitin		Ubiquitin family	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.96	0.72	-4.58	76	11560	2012-10-03 10:59:06	2003-04-07 12:59:11	18	265	901	508	6203	11456	369	67.10	44	28.05	CHANGED	+shssp........phslclp.ssolpplKpclpppps...lssspQ+LlasG+.L..cDppslt-aslppss..slplshc.p	.........................................+olsGK......slsl..-.V.-..s.o.D........T..l....c.sl.K..s....K...I........p..-..+cG.............IP.......P..-.......Q.Q...RL...I........F.....u........G......K......p.....L......-D..........s...........+......T..L.....u.....D....Y.....s...Ip.....cpo......TLHLVl+...................................	0	2304	3483	4906
+959	PF00789	UBX		UBX domain	SMART, Mistry J, Wood V	anon	Alignment kindly provided by SMART	Domain	This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.56	0.72	-3.92	22	2190	2012-10-03 10:59:06	2003-04-07 12:59:11	15	58	327	23	1473	2158	19	82.40	21	19.37	CHANGED	spstsssplplRhPDGp+htc+F..pscslpplhpalpspt.sts....p.........................FpLhsshP..R+.hspps..poLp-s.thhssuslllph	................................................p....stsplplRh.s...s...G...p...p..l.p.p..c.Fp..sscsl..p....s.lh.p.al...p...s...p...t....s...st.....t.............................................................................F...p...L....h.s..s.a.P.....p+.......h........s....p.p..s............t......oLp..-h...hh.ss.u.slh...h.................................................................	0	463	739	1131
+960	PF00443	UCH	UCH-2;	Ubiquitin carboxyl-terminal hydrolase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null --hand HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-12.07	0.70	-5.28	53	8903	2012-10-10 12:56:15	2003-04-07 12:59:11	24	248	429	43	5798	8963	637	380.20	19	45.37	CHANGED	hsGLtNhGNTCYhNSlLQsLht..ssthp.chlh..............................................p...............stpst.ttts..........................................................................................................................................................lspthpplhpphhps......................pppsltPpt.............................................................................................hhptlsthtpp..hp.......shpQpDApEahthLL-pLccshpt..t.....................................................................................tt.shl..pclFpGphpsplpChpCsppspshcshhslplslttppph....................................................................................................................................................................................................................................................................................................................................................................................................................phhphpttpthptppphhsspspppppuhKphplpcLPp.lLhlpLcRF......aph.ptth...ppKlspplpaP.....h.pLDls....shhttstt.................................................................................................................................................................................................................................................................................................................................................................hpYcLhuVlsHtG.s.......hpsGHYhuahhp.........ps..............................ptt.......WhpacDspVsphs................ppl.hp.............................psAYlLFY	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hGL.N..h..G..N.T........C.ahNuh......l..Q..............s........Lh.t...h....hp...phhh...............................................................................................................................................................p.....................................tt......t....t..t.t............................................................................................................................................................................................................................................................................................................................................lhpth.t.p.l...h.tt.h.ps.....................................................................t.t.p.s.h..s..P...p..t.........................................................................................................................................................................................................................................................................h...h...p...t....l.....t...t.h.t..p.......ht.........................shp..Q.p.......D.......u........p........E.......h.h.............t.......h..l......ls..t..l...c..p.p..hpt................................................................................................................................................................................................................................................................................................................t...t.t..p...s.hl..........pp..h.F.....t...G.....p.....h...p.......s........p.......l...p.....C.......p...Ctphstp.pshh.lpl.h..ttt...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.httttthhstpspthtpsp+phpl.t.ph....P.......l.L................h.l.......p.......L.......p......R..F..........................hp.....t............................htK....l.sp.h..l.p.aP.....................t.Lc.hs...............hh..t...p...t......t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhY.p..L.h..u.V......l....s...H................G....s..................h.p...s.G...H.....Y..h......sa..hpp.......................tt...................................................................................................................................................ptt..............Whh...as..D....pp..V..p...h.p..............................ppl..p...............................................tpuY...hLhY.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2079	3020	4452
+961	PF03456	uDENN		uDENN domain	Callebaut I	anon	Callebaut I	Domain	This region is always found associated with Pfam:PF02141. It is predicted to form an all beta domain [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.27	0.72	-4.00	45	1381	2009-01-15 18:05:59	2003-04-07 12:59:11	13	72	202	2	776	1312	4	65.10	30	5.71	CHANGED	pPcllppaPp....p.........pcp.h.pslshFCFPpGlshhspp........psphFsFlLTctDGs+h.aGhChphh	................splltpaPpps........................ps....h...pslshFChPpG.h.ph...ts.s......................tsphasFVLTs.t..........D.u..s.+p.a.GhChphh.....................................	0	186	286	501
+962	PF03167	UDG		Uracil DNA glycosylase superfamily	Aravind L	anon	Aravind L	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.75	164	10115	2009-01-15 18:05:59	2003-04-07 12:59:11	14	32	4976	114	2700	7557	3938	160.00	22	68.49	CHANGED	.shsssssc.llllGpsPGt.pp......st..sGtsFsst.........sGphLpp.hl.tph............................ulscpp...................lhlsssltp......................t..ttpssps-hpts.ps...hLhpplph.hp..Pclllhl.GptAhpthh.h...........h............................htth.lhshhHPSsh.tt.....................hp.t.h.phhp.pLp	..............................................................................h.....tss+llIlGpsPht..ss............pt........pG...hsFss..................sss.p.Lhs...hh...ppl..................................................................................uhs.cps...............................................lhlhNsl.......................................................hss.pp.s.s.p..sch..sts..pt....................tlhp..tl.sp...hp......t.........l.....l...hhL..Gph.Atpphhh..h..................................................................................sttphhll...ssHPSslstt.hth.................hsst.h.tps.t.L.........................................................................................................	0	865	1704	2249
+963	PF02809	UIM		Ubiquitin interaction motif	Aravind L	anon	Aravind L	Motif	This motif is called the ubiquitin interaction motif. One of the proteins containing this motif is a receptor for poly-ubiquitination chains for the proteasome [1]. This motif has a pattern of conservation characteristic of an alpha helix.	20.40	2.90	20.40	4.00	20.30	-999999.99	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.07	0.74	-6.49	0.74	-3.89	46	2346	2009-09-16 13:18:06	2003-04-07 12:59:11	15	72	279	15	978	2205	32	17.30	40	7.58	CHANGED	tpE-pcLphAlthShp-t	.........pE-tc.LptAlphShp-.......	0	264	430	695
+964	PF01027	Bax1-I	UPF0005;	Inhibitor of apoptosis-promoting Bax1	Bateman A	anon	Pfam-B_1376 (release 3.0) & Pfam-B_5704 (release 7.5)	Family	Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localised to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localise predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress [2]. BI-1 appears to exert its effect through an interaction with calmodulin [3]. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner [4].	26.10	26.10	26.20	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-12.10	0.71	-4.72	511	5798	2012-10-01 20:22:31	2003-04-07 12:59:11	15	12	3474	0	1486	4003	2434	202.60	25	84.39	CHANGED	pphl.ppsYshh......uhu....lh.lo.uhsuhhsh..................................h.....hhhhh.......hhhs.....luhl.h.h.s...h.tht............p.....sss........hs.hh......hhh...sasslhGhslus................lhhh.......ht................sshlspA..hh.....hTushFsuhohh...uhpo...++........D.......ho.th..GshL...h........hull..sl....lluulls.h.F......h...........ssshphsl.u....hlu....lllFs.Gh..h...haDT...p.pl....h..........p.....ththtsh.................................lhuAlsLYL.....DhlNLF...l.h...lLp...l.h	.......................................thl.ppsYhhhulsLh...ho...uhsAhhs.h.h..................................hh....hh.h.hh............hhl.st.....lshh..h.h..h.h.h...h....thp.............................................p...h.sss..........hh.......hhh...........hao...shhGhslus...................lhs.h.Yh................ssslhtA.....hs.....hTus.hFh.shohh.....uhpo...++.........................D........ho....th....GshL...h........hull....sl.......llus...llN....h...F............................lt.................ssslthsl.o.............slulllFs.Gh....l...ha.DT......p..pl.....h............p.....tht.ss..................................lhuAlsLYlDh...lNlFl....lLplh...................................	0	437	786	1139
+965	PF03684	UPF0179		Uncharacterised protein family (UPF0179)	Bateman A	anon	SWISS-PROT	Family	The function of this family is unknown, however the proteins contain two cysteine clusters that may be iron sulphur redox centres.	25.00	25.00	69.70	69.30	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.06	0.71	-4.62	24	104	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	103	0	79	109	6	141.80	37	95.34	CHANGED	hITLlGpcLA+sGsEFlahG.sscCcsC+h+psCh..NLp.G+RY+llpVRsst..pcChlH.-ssVpsVEVtcs.slhsllpo+pAhcGuplohpss.Cs..h-CpsachCpP-Glhpu-+hpIhcllGcht...C.tG.+plplVclthh	....hITLlGpcLAcsGtEFlahG.ss.cCcsC+h+phCh..NLc.G++Y+ls.sVRsst....ppCslH.-ssVpsVEVtcs.slhshlpu+tAhpGuplshpss.Cs..h-Cptac..hC..pP.-.GlhpG-+h+IhcllG-h.t..C.pG.csLphVclh.h......	1	16	46	63
+966	PF03699	UPF0182		Uncharacterised protein family (UPF0182)	Bateman A	anon	SWISS-PROT	Family	This family contains uncharacterised integral membrane proteins.	19.40	19.40	22.50	23.80	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	774	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.59	0.70	-13.39	0.70	-6.60	63	654	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	582	0	224	642	800	783.20	35	82.82	CHANGED	p+s+hhhhlhhlllhlllhsh....hsshhs-hhWFpplG....atsVFhTplhsphhlhlhs.................................................................................hllhhlhlhlslhh.sp+st..........ht..h.t......ht.....................t.hhhhhhphhhhslshllullsuhhsuup.WtplLha....lssssFGpsDPlFstDluFYlFpLPhhchlhshlhshllluhlhsllsa................hlhusht.......hsstth...tlsptsptpLulLhulhhLlhAhuaaLcpapLLao..s..pGs.hhGAuYTDlpstLPshhlLshlullsAlh..h..................hhsh.................hppph+h................shhuhslhllssllhsslhPtllQpFhVpPNEhphEpPYIccNIshTRpAa.sL-p..lc.hpsasspss..Lsst.s.....ltpspsTlsNIRLhDspPLhpTapQLQQlRsYYpFsc.lDlDRYpl.sGp........................hpQVhlusRELs.ssLstpupoWlNcHllYTHGYGhlhuPlNpl.............os-GhPpa..hlpDIPsssph..................sltl...ppPRIYaGEh.......ossYsIVs.s..pst....EaDYP...............................................................pus.pN.shspYsGsGG....l.lsshhpRllaAhphp-hplLlSsslss-S+ILapRslt-RVcclAPFLphDuDPYhVl.sc........G+................lhWIlDAYTTSspYPYSp..Ptp......................pslNYIRNSVKslVDAYsGoVsaYlh.DtpDPllpsap+lFPslF+PhuphPssLpsHlRYPpDLFplQsphlspYHh.....TDPpsFYsp-DhWplPp.....-..........................hsss.....pts...............htPYYllhpLPs........ppptEFlLh.sasPts......RsNhsAaLuARu......Du........psYG+lllaphP..+pchlhGPtQlpspIsQDspISpploLW	...................................................................................................................................................................h....hhhhh.hh.h.lhl.llhhh...hhsshasDaLWFsplG.......apuVFhThlhs+lslhlss...................................................................................sllhu.shlhhs.hhl.AhRs+.s.sh..s.s...s.........psltth........................................................................................................................ctsh.tp..h+hhhhslsl.llu.lls.G.hhspup..Wt.plhha....hpussFGhpDP.FGhDluFYsFpL.Phhchllshl...hshllluhlssllsa............................................................................alhGul+............hss.t.t.s.t.l.ops.A+hpLullsulhhLlhAsuYaLcRYpLLhs.......ppss...hsGAuYTDlpAsLPuphlLhs..lul.l..sAlh.....h..................h..ss.l...................hh..+..sh+l................................Ps.l..u.hslhl.lsul..l.lG..s..h..a..PhllppFpVpPNttphEpsYIp+NIpATRpAY.GL..ss...lp.hp..s....a....s...u..s..ss......h.s..sp.p......................l.tsstsTlsNIRLhDPpllssoapQhQQ..h+saYpFs-.LslDRYpl...sGp...................................hpshllAsRELs.ssLstp.ppsWlNcHhVYTH.G..Ghlsu.uNpV.................s.ssGhPta..hlp...slsspuph..................slsl...ppPRIYaGph.......ss-YuIVGssts.....EaDYs................................................................psp...ts...sphoY...s.G...sGG....lslushhsRhlaAh+at-hphLhSstlsspS+.ILapRssp-RVppVAPaLTh.....D.....u....csYPsl..lsGR..............................lhWIlD...uY..TTsssY..PYSp..hsshtt....................tpplNYIRNSVKAsVDAYDGoVsLYth.Dpp..DPll+sWt+lFP.G.hh+shu-hs..s..-LtsHlRYPcDLFcVQpplLs+YHV.....sDPpsFasspDhWplPp.....-.............................s.s..s..sp.....spt.......................psPYYlhhp..h..Ps........pspsp...Ft..Lhosasshp......R.p.LsAa.luucS...Ds...........ssYG.....clplhp.l.P..p...s....s.l....GPtQspsphspssplSpplsLh................	1	84	173	210
+967	PF03676	UPF0183		Uncharacterised protein family (UPF0183)	Bateman A	anon	SWISS-PROT	Family	This family of proteins includes Lin-10 from C. elegans. 	19.80	19.80	21.20	20.40	19.20	19.70	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.37	0.70	-5.88	8	356	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	220	0	262	349	4	251.20	23	75.90	CHANGED	GsctWEFlLGMPIuQAluIIppQsplI+sVpVhYSDpsPLshDllIslPsDGl+LhFDPhsQRLKlIEVaslpplpL+YsushFNSPsllPTl-plpp.FGuTHPGlYDsu+plasLpaRGLSFtFPlsS.....+apssaucGLu...SLcFssGuoPlloRMSIYsGus.........lsEu+sP.sLPhuCahGslYhEpVcVl+puts.shGlcLpLsspG...shhhE.chpshpRplhFGDSsQDVhSsLGuPs+VFaKoEDKMKIHSsSsHR.spo+suDYFFNYFoLGlDILFDupTHcVKKFVLHTNaPGHasFNhYpRCpFpI.l.............sDpssssssspps........ITshoKWDplpchLusst...+PVVLpRuSospp.NPFGSTFCYGYQclIFEVM.Nsa.IASVTLY.sus	................................................h.........G....h.....phht.lp.t..t..h..hp..lha........t...tPht...s.lhl.hsttuhpLhF-s....QpLphI.........El........hs.......h..p........h.............hhat.............t...........................h.................t........................t............................s........s........h.tl....t...F.G.s.oa.......P..G..............t...................t......................ahL.a.GlsF.F..h....................................................ttst..........htp.h.la.utp.............h.ps........h.............................................................................................l.h.s.....t.o.s.p-lh..hG.......Pttha.Kt.pph.lH........................................................................................................................................Khlhhs.s...tp..h.............................................................................................................................................................................................................................................................ts......................................................................................	0	89	144	210
+968	PF03671	Ufm1	UPF0185; 	Ubiquitin fold modifier 1 protein	Bateman A, Coggill P	anon	SWISS-PROT	Family	This is a family of short ubiquitin-like proteins, that is like neither type-1 or type-2. It is a ubiquitin-fold modifier 1 (Ufm1) that is synthesised in a precursor form of 85 amino-acid residues. In humans the enzyme for Ufm1 is Uba5 and the conjugating enzyme is Ufc1. Prior to activation by Uba5 the extra two amino acids at the C-terminal region of the human pro-Ufm1 protein are removed to expose Gly whose residue is necessary for conjugation to target molecule(s). The mature Ufm1 is conjugated to yet unidentified endogenous proteins,[1]. While Ubiquitin and many Ubls possess the conserved C-terminal di-glycine that is adenylated by each specific E1 or E1-like enzyme, respectively, in an ATP-dependent manner, Ufm1(1-83) possesses a single glycine at its C-terminus, which is followed by a Ser-Cys dipeptide in the precursor form of Ufm1. The C-terminally processed Ufm1(1-83) is specifically activated by Uba5, an E1-like enzyme, and then transferred to its cognate Ufc1, an E2-like enzyme [2].	21.70	21.70	22.30	25.90	18.70	21.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.53	0.72	-4.22	2	177	2012-10-03 10:59:06	2003-04-07 12:59:11	9	5	139	3	104	152	2	72.40	75	67.89	CHANGED	uKVSFKlTLTSDP+LPaKVhSVPEusPFTAVLKFAAEEFKVPstTSAIITNDGIGINPtQoAGNVFLKHGSELRlI	............uKVoFKITLTSDP+LPaKVlSVPEu.TPFTAVLKFAAEE...FKVPs.sTS.AIITN.DGlGINPsQTAGNVFLKHGSELRLI............	0	41	60	83
+969	PF00179	UQ_con		Ubiquitin-conjugating enzyme	Ponting CP, Schultz J, Bork P, Finn RD	anon	Prosite	Domain	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-4.75	71	9194	2012-10-02 15:28:41	2003-04-07 12:59:11	21	127	571	270	5880	8415	316	134.10	27	49.81	CHANGED	Rlt+Ehp......ph.cpsssuhpst.hs....c.....slhpWpshIhGP.psTsY-uGhFplplpFPpcYPh.pPPpl+Fh..o......................claHPNlp.tsGpl......CL.sILp............pp.......WoP.shslpslLl.ol.uLL......spP.NspsPhss-sA...phapcs.pp...paccpsp.th	..........................................................................................................................l.p-ht........ph.....p...p......s.......s..h..p.s.t..s......p...................slh..p.W.ps..h.I..h..........G...P.......s.......s....o....s............Y...........c...G...........G..........h...........F.......p...........l..........p...........l.............ph..P.....p.............c.Y..P.........h..p......P...P....p........l......p...Fh...o..................................................p.l..a.....H....P.......N.............l......t....s...........s.....G..p....l....................C.L...s...l..Lp........................................p.p...................WsP...shs.l...p.......s......lLh...ul......p..u........LL.............................spP.....s....s...p....s...P.....h...s.....phu...p....h....h...p...p....t....ta.t.h....h.................................................................	0	1995	3131	4649
+970	PF02814	UreE_N	UreE;	UreE urease accessory protein, N-terminal domain	Bateman A, Finn RD	anon	Pfam-B_6279 (release 6.1)	Domain	UreE is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid.	20.80	20.80	20.90	21.40	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.02	0.72	-4.46	70	1294	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	1157	35	261	891	364	64.20	27	37.70	CHANGED	hls.shpthtt.tsss..ttplsLsh--Rp+pRhRhpsssGp.-lulpLs+s.sh.LpsGDlLht--Gph.l	.................h.........t...tttp.....s-plhLshp-ttKpRhRhsos...p.....Gp..-lulpL.tcs..hh...LpsGDlLht--sphl......	1	57	144	203
+971	PF04192	Utp21		Utp21 specific WD40 associated putative domain 	Wood V, Finn RD	anon	Pfam-B_16350 (release 7.3);	Domain	Utp21 is a subunit of U3 snoRNP, which is essential for  synthesis of 18S rRNA.	22.10	22.10	23.10	23.10	20.20	19.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.40	0.70	-5.26	28	330	2009-01-15 18:05:59	2003-04-07 12:59:11	7	21	284	0	242	331	2	226.30	30	24.85	CHANGED	hlEu..Ah--pppc........pppth.......YpSh-QlscsLlTLSlhPcS+apsLLcLDlIKpRNKPKEsPKtPEpAPFFLP.ossslsspt....................t.sspp........scstsctsclsclp.sspht..tpSpFopLLcp............usps..s-YsphlcaLpshuPuslDLEIRSLs.......s..hsshsElhsFlculsptLcop+sFELspAahulFLK.........lHuDllhp.......ssp.........................LtcsLppWpstpccphp+Lc-LVtastuVluFl+o	..........................................................ttt.ht...h.o..cQl......sp.pLlTLS.h.lPcS+WpsLLpLDlIK........pRNKP..........p........Es.PKtP..c...p.....APFFLP..ohsslssph.........................................................................................ptpp........................pppp..spt...sph.sph.p......t........popF...sp.hLpp......................................................................ut..ps....ss......asshlphL+sL.u.P.S.s.lDhEl.RoLs.....................s...tssh..pt.hht....F....l....c....hlsthLp.s+csFELsQAahulFL+.........lHschl.h.p....psp.................................Lhptlpphpp.p..ppphp+lppLht.shsllsalp.........................................................	0	84	137	203
+972	PF02151	UVR		UvrB/uvrC motif	Mian N, Bateman A	anon	IPR001943	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.60	0.72	-4.32	72	12483	2009-01-15 18:05:59	2003-04-07 12:59:11	14	46	4610	17	2727	9003	4562	35.60	34	5.61	CHANGED	pphlp.pLppchppAscppcaEcAuclRDplpplcpt	..............phlp.cLcpcM.ppAu.csh-FEcAAplRDplppLcp.h..........	0	966	1868	2351
+973	PF05008	V-SNARE		Vesicle transport v-SNARE protein N-terminus	Moxon SJ	anon	Pfam-B_5492 (release 7.6)	Family	V-SNARE proteins are required for protein traffic between eukaryotic organelles. The v-SNAREs on transport vesicles interact with t-SNAREs on target membranes in order to facilitate this [1].  This domain is the N-terminal half of the V-Snare proteins.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.81	0.72	-3.82	89	491	2012-10-01 21:14:52	2003-04-07 12:59:11	10	8	290	5	319	473	11	77.00	26	28.67	CHANGED	aptlpsplppclsphs..s...s..-..p++ptlpclcppl-EAppLlcpM-lEsp.sl..P...s.+sphps+lRpY+s-lsp.l+cchcp	..........................ap.lpsp.lppphsp.h.......phs.u..-.......p++phlpph-ptl-EAp-LlcpM-lEsc.sl....Ps.......stR...sthps+lRsY+p-lsp.l+pch+.....................	0	111	177	256
+974	PF00790	VHS		VHS domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain present in VPS-27, Hrs and STAM.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.53	0.71	-4.55	15	1706	2012-10-02 18:21:09	2003-04-07 12:59:11	14	40	287	48	1025	1655	5	130.70	28	24.38	CHANGED	ss.sp.lpthlp+ATcpsls-s..Dhuhhl-lsDhIsps....sssP+-AspsIpK+lss..psspsulhALslL-sCVKNCGppFHhclus+-Fhs-Llphlspcs.sc.....V+pcllcllppWspsh....cpcschphlpDhachLKhcG	............................s.....htthl...p..+ATs...t....t..h......pt...DW.s.h.h..c.lC...D...h...lspp............tsus...+....-Ah+u.lt++lpp..........pss...p...ht.........h.h.........A.........Ls.............lL-sslc...N..CGppFH..hp.l....u.........sc....c.F.l.s......c.l.l..c...ll.ps.ph.t.....st...................VppKllpll..psWs.p.s.h.....p.ps.ph..s..hltphap.LptpG.....................................................................................	1	272	484	768
+975	PF00654	Voltage_CLC	voltage_CLC; 	Voltage gated chloride channel	Bateman A	anon	wublastp P37020/1-588	Family	This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 (Swiss:P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney [3]. These proteins contain two Pfam:PF00571 domains.	23.80	23.80	24.10	23.80	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.28	0.70	-5.43	139	7727	2009-01-15 18:05:59	2003-04-07 12:59:11	15	38	3515	57	2231	6126	1048	337.70	23	63.73	CHANGED	lsuhls.......uhlhthh..sts...t...u.sGlsplhttl...pttpt.h.....lsh+shhs+hlus..llsluuGtSlG+EGPslplGAslushl..u...........ph......hth..ttsp.p+h.LlssGuAAGluAsFssPluGslFulE...............lh.tph..sh.......ps....hhsshluulsushlsphl........hu.t..sh...........as.....lss................hshhtlhhhlllGllsGl.hushFsphhhtsp.p.....hhpph.....h..............hh.pshlsuh...ll....uhlu....hhh.......................P.t..hhGsGh.......sh.........................................................................................................lpthh...sst...................................................hhhhhhhhhhlhKhlhTslohuuGhsGGlFsPsLslGAslGt.hh.....u.hlhthh........................h..................sshullGMuAhhuusspuPlouhlllhEhTu.shphllPlhlushluhhluph	................................................................................h..hhhs...shl...ht..hh.........stt...t...u......p...Gls.p.l...ht..tl......ps....h............................h.hps.hhhK.................h.lus..lls....lu..u...G..h..slG.............+...........E.............GPhlpluuslu.phlu..................................ch...............hp.h.......p.sc...p+h..llusGuA...AGluAsFsAPl..u....G.......slFsl.....E..............................lh..tph..ph...........................tshhss..hhu....ul.sushshphh..........hs.t..sh......................ht.............ls.h..........................................shs.h.t.p.h.h.hhll.l.Gl.l..s.....G..l.....hGhla.p...hhhthp....p.........................hhp..p....h........t.h.............hh..hshls..uh.lh.....ullu.....hh.h..........................................s..t..hhG...s.Gh...sh.......................................................................................................................ltthh.......tst....................................................................hshh.hlhhhhlhKhhhoh..lo.h...uuGhsGGlFhPsl......hl..G...uhhG.thh.....u..hhhshh................................................................................s..sh.hul....l...G.h.uuhhu..uss+s...................P.loshlllhEhT.......s..s.......h.p.......h...........l.hsh.hls.sh.huhhlst.h............................................................	0	710	1253	1782
+976	PF04840	Vps16_C		Vps16, C-terminal region	Kerrison ND	anon	Pfam-B_6003 (release 7.6)	Family	This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [1]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole.  It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport [2].  The role of VPS16 in this complex is not known.	36.00	36.00	36.20	36.20	35.90	35.60	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.73	0.70	-5.48	5	345	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	273	0	252	368	2	283.70	30	37.70	CHANGED	lSascIA++AYpsGRs-LApKLL-hEscuup+VsLLLpMccsctALpKAIcStDssLIhpVLLcLKpchspSsaahsLpcpPhAlsLYpcasRcp-+cT.......LaDlYpQ-DcapclApaHlcsuhts.ccs-uRlouLppAuDAaupu+s.slEscss-Dph....+Ll+lQcoLpccasssFssLSl+-TVscLI.sGcsK+AccL+p-F+IPDKRlaWLKlcuLuct+KWEELEcaApS.KKSPIGYtPFVchCl+pcNhcEA+KYlsR...lss.p-KVchalpsssas-Au-lAh-cRDtssLp-lhp+hssss-ushss+Vpsslcp	......................................................................................................................lSaspIAttAhppGRtcLAhp....LLphEspu.scQ..................VPLLLp........h.p.c...........pchA..LpKAlcSGDsDLlhhVLh.p.Lcp.c.h.s........h..u......p.....Fh.h.hl...pp....ps.h.........A...........s....L...ht.t.......hs.+..p....p.phph.................................Lc-ha......p.....sD...ph.....-hu...hh.lppuht............p.........p........................ps.........p..ht.......t..L....p.......At..c..h.h......t.p.s..+...p.......t..h...t...t...p...h..hp-ph..................pLLc.hQ.cpL..-....pc.....h...s.............t.............p.............F.h........s.h....Slp-T.lhpL...lh.....h.......G.p...t............+.........p.....Apcl.....tp-F.+l.s..-K+a.a.al+lpuLs.pt.cc.W...p..-L-....c.h........u........+......p...K.......K.S.......P.........IGapPFhphhh.p.t.s..p.t........t.p.At.pals+......lss...pp+hcha...hths.hhpAup.Ahct+s.t.Lt.lht.h.......................................................................................	0	95	149	215
+977	PF04841	Vps16_N		Vps16, N-terminal region	Kerrison ND	anon	Pfam-B_6003 (release 7.6)	Family	This protein forms part of the Class C vacuolar protein sorting (Vps) complex. Vps16 is essential for vacuolar protein sorting, which is essential for viability in plants, but not yeast [1]. The Class C Vps complex is required for SNARE-mediated membrane fusion at the lysosome-like yeast vacuole.  It is thought to play essential roles in membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of transport [2].  The role of VPS16 in this complex is not known.	22.00	22.00	22.60	22.40	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	410	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.35	0.70	-5.94	5	393	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	278	0	293	403	5	326.60	26	46.86	CHANGED	Pou-WphLcDs.YYRKptLuos-WsLch-l.chhlulAPaGGPIAVsRsP.phpss..hs.hPh..IpIashSGplLu+.lsWsp..sslVuMGWocsEELIlVsKsGpVhVYuhhG-h...paSlGcsl...pssclpEs+lFpoptGcoGVAlLssucclhllsusucslhh+phP...-lPsspophpstsssspI.....LssDcshpIhlssGssLt.Is-pu..ps.............lsS.p+alKloVS.s+p+LALYTsoGplhllSsDhuccLCEacls...t+usPKQMs..WCGN......DAVVlua.EshLhlVG.....csG-pVsFhYchT.sh..LssElDGVRIlTpoopEFLp+VPAsoENIF+IuSpsP...GAhLlEAtpchEc...+SsKA-EhLpplp-..pLccAVs-CIpAAscEFpPEhQKsLL+AASFGKuaLcpasPD..cal+	...............................................................................................................................................................................tW..h......hap....t.hh.t......a..............t...............h.......p...hhl.ss.us.uGsl....Alh.ps...................................t...........lplas.s.G......l.tp...h.a..pt.............s..lh.thsW.st....p.-pLl.sl..psGh.h.h.h.a........s.h.....uph.................h...s.h.sp.th....p.tl..p..s..............................h.sG.hsh.....l.h..t.s....p......h..h.h..tsh....t...............t..h.................t...st........................................................h.........p...p...h......l...hh..s.....s.....plh.l.....ttt.......................................h........................hhphslS.stp.hl.Ahh......s.....t.s....G.....h...l.....h.h..h........s.s.shp..p.h.h...-hss.p.....................pt..P.p..ph...WCup.................c..ulh.l........ta...p............p.......lhllG...............................stsp...h..pa..h.s....t......h........................lhsEhDG.lRlh..opsph-hlpc...VPt...s...s...........tplFplu.S.h..sP...........uuhLh-uhcphpp.................pu.....+A.--...lp.l..pt.........pL.pAVppClpAAst.E.a...psp.hQ+p...LL+AAsaG+sh.hp..h..p............................................................................	0	115	177	250
+978	PF03635	Vps35		Vacuolar protein sorting-associated protein 35 	Finn RD	anon	Pfam-B_3569 (release 7.0)	Family	Vacuolar protein sorting-associated protein (Vps) 35 is one of around 50 proteins involved in protein trafficking.  In particular, Vps35  assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps26 and Vps29.  Vps35 contains a central region of weaker sequence similarity, thought to indicate the presence of at least three domains[1].	21.20	21.20	21.30	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	762	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-13.43	0.70	-6.39	23	430	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	295	2	300	460	7	646.70	38	90.35	CHANGED	+hLpEAlssV+pQuhhM++sL-p.scLhDALKauSsMLsELRTusLSPKpYYELYMtlFDpLphLssaLt-p+spt.++..........................LsDLYElVQaAGNIlPRLYLhITVGosYlcsp-uPsKEILKDhlEMCRGVQHPlRGLFLRaYLsQto+-hL.Ps.s....................ppsssGslpDol-FllsNFhEMNKLWVRlQH.....................................QG.s..............+-+-+Rp+ERcELplLVGoNLVRLSQL........-GlshchYpcsILPplLEQlVpCRDslAQpYLhElIlQVFPDEFHLtTL-.LLsus.spLpPsVsl+pIlhsLl-RLusYsspps-sp.p..t..........................................................................................................................................................................................................................slclFplFhsplspl........lc.s+schs..........................................................................................................................................lpshlsLhsSLlsLsLpsYP..-pl-hl-plhshshp.hlpph........tsphpsspsppplh...................pLLhh.................Pl.pp........ahshhslLplpsa.sLlshhshps.pKsluhsllssll.....................cssoh...................................Issh-pl-plhpllpsLI...................p-psDp..t.....................................................-s--ht-EQphlu+llHll....p.s-........Ds-pphclLtssRKthhpGG.pRl+aThPsLlhshl.........+Lsp+hptpp.............................................................................................papspspplF+alHp..slssLhshss....s-LsL+LaLpsAtsADphs.............lp-...luYEFasQAFslYEE......................sluDS+sQhpAlthlluoL.p+h+shs..cENY-sLhsKsshauSKLLKKsDQCRuVhhCSHLaWssch.........................................................h+-uKRVLECLQ+uL+lAcsshp.......sssslpLFVElLN+alYYa...-pssspVoscalssLI-LIpssh	................................................................................................................................................................................hLt-ultsl+.psh.M.....++s...L-p..spLh-ALKpuophlsEL...........R.....T.....s.LuPKpYYEL..................Y.....MtlhDt.Lp.hLphaLh......-ph.t.....pp......................................................................ls..DLYE.lVQauGNIlPRL.YLhlTVGssYhp......t..t....sh+-lhKDhhEMsRGVQHPlRGLFLR.YL.phs...+.shL.Ps.s........................................ptstGslpDuh.pFlL.NFhEMNKLWVR.h..Q.H.......................................................QG.u..............+-+-pRppERpELplLVGoNLVRLSQL....................t.lsl-hYpphlLstlLEQlV.pC+DslAQpYLh-slhQ....V....FPDEaHLpTLs..hLpus.spLps.....pVslK..............pllhsLh-RLutastppsts..................................................................................................................................................................................................................................................tplclFphF.pplspl...........lp...sp.phs.............................................................................................................................................pshlsL.suLhslsh...p.haP...........-cl.-a.l.DplLthshp.hhpph..............tt.....psstsp.pplh...........................tLL.h........................Pl...pp........a.slhshLpL..pa..lh.ph.s.hts.p+thuh.llpsll................cp.p.s.h...................................lss..-p.....l-tlh.pllpsLl...................p-t....pt.s.t........................................................-s--hh-EQshluRhlHh.l........p..sp.............-s-p..phtlLphs++thh....tG.s...pRlpaTh..Psllhssh.........pLsh.phpt.p.........................................................................................................................................tpphptpspplapahpp..slssLhpt...................s-LsL+L...aLpsu.sAs.p.hs.....................hEp...luYEFhsQAFslYE-........................pI.u.DS+sQhtAlphIhush...pp..........hpshs....pE.N..a-sLhspsshhuuKLLKKsDQsRuVh..hsuHLaWssp..........................................................................h+sucRVh-CLp+uL+lAstshc..................sshplpLalElLs+Ylaaa.....-pt.stt....l.ohphlstLIphIppp.h...............................................................................................................................................................................................	0	117	178	255
+980	PF04129	Vps52		Vps52 / Sac2 family 	Wood V, Finn RD	anon	Pfam-B_10164 (release 7.3);	Family	Vps52 complexes with Vps53 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events [1].	22.60	22.60	22.90	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	508	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.63	0.70	-5.98	5	461	2012-10-03 17:31:52	2003-04-07 12:59:11	7	15	279	0	310	506	9	381.30	24	70.45	CHANGED	lEpcSIcDhIp...............................ESpNluoLHNQIsuCDuVLscMEshLsuFQs-LusISoDIcpLQEKSscMslpLcNRpuVcu+LuphV-DllVPP-LIcsIl-GcVsE......spasopLplLs+htusscDQu.....s+uopAsKDVc...slLDKLRsKAlsKIRcaIlpKIhsFRKPh.TNhQIlQs.sLLKaKaaapFLhcNsRclAhElRsAYI-TMsKlYhuYF+uYlppLsKLQa-cusop.DL.hGVE-sus.......uLFFS..............KssoL+p+sslFolGcRssIls.tpl-sPllVPHIApssp.+YshEsLFRShchALlDNuosEYhFlsEFFslsGsptc-l...FppIFu+TLohspKalpslIusCaDsIGlhLsIRllp+aQLhup+RsVP.sLDsYa-ulllhLWPRFchVhDhplpSLRcssloshst............h-o+PHYlTRRYAEFouSllsLulsassup...lspLLscLpp-V-sFlL+lAKpFsc+KcQllFLINNYDhlluVLpEtus-suKEscsFpEhLNusospFl	..............................................................................................h...t.h.tttl.t.t.spthl.t...p.hc.......phLttFpscLsslos-lppLQppS.ths.pLpNRpthpt.Ls.hlptl..lssthlp.Ihp..s.....lsc......................h...t....p..............p..ph.h...h...........tp..t.....................................pt...tu.....ht-lt...s.lppLp.+...........Aht+l+............cal....l........t....p...l.hthR..........ps..................hN.......hQ.....h.Qp...th.......l.+.h.+............hh.tFLhtpt.thstElpptYhpTh.ph.......h.ah....sha.p.pY..ttL....p....lphp...hspt...sl...s..tt...t...........................t..h.......................................................t..ttha....t.lspR.h.pllp.....p.......p.t..........s....h......h..........................s.......h........s..........pt..............s.......t.............h.....................h...EhhFRs.phhLhDssstEa...........Fh.pFF.........................tph.........................h.tlh..t.sht.hh.p..hp.........p..h.l..t..............t..s..h.D....shulhl..hlpl..p.h.t.........h.t.p.R.....p..l..s..sh-.....ta.hpth...lWP+hp.lhphphpS.lp...p..h.s......t.......................................t.ts.+....ls.ppauph.tuhl.l....s..............t..h....pt.........................h......h.pl......t.hpthh.th......s....t.........................p........p......t.t....haL.hsNY.hhhsh......l......p..............................................................................................................................................................	1	127	191	270
+981	PF04100	Vps53_N		Vps53-like, N-terminal 	Wood V, Finn RD	anon	Pfam-B_5601 (release 7.3);	Family	Vps53 complexes with Vps52 and Vps54 to form a multi- subunit complex involved in regulating membrane trafficking events [1].	24.00	24.00	24.20	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.37	0.70	-5.68	7	406	2012-10-03 17:31:52	2003-04-07 12:59:11	7	9	287	0	282	410	14	328.10	31	47.32	CHANGED	tschssl-hINplFPs........................-tSLssl-plh.......p+lpt-Ip+lDssltshVcspsNsGpcup.sLp-AppulppL.pcIp-l+s+AEpoEthVp-lTcDIKpLDhAK+NLTsolTsLp+LpMLssuh-pLpthhppppYuchhs.hpuhhplh.phFptYpsl.pItpLppplsphptphhpplhpsapphF....ustsppc.u..hphLsDuChVhssL-ssl+cpllchFhpppLp-YhplFt-spEhuhLDcl-+RYsWhK+hLpsa-pt.htslFPtcWchshRLshpFC+.TRppLtpIhhp..+ccc.slclLlhAlppThpFEphLs+RF.............................p...E.c.ht.......................FcshlSSCFEPHLslYIppp-ppLtchh-phsp-.ph	..............................................................t..casslpalNthFsp..........................po...L.s.s.lsphh...........pplp.php..pl-ppIt....ph.lpt..Qs...............ss..ppu.ptlppA.p.tsl..................t.pLht+Ipcl+p+AtpoEphl...pphTpDIK.pLDhAK+pLTtohT...sLp+LpMLs...............suh-pLpt..hsp.p.....+.p....Yt.-sup.L.................p..ulhplh.paF.............p...pY.p.s......ls.p..ItpLppplpthpppLhpplhtD.Fc...h.a........................st.t......t..p..........p.Lt.-uCh.VhssLss..p..h+..pcllphahp.pp.LppYt.lF.p..................ts.p......-......su.L.....DplsRRYsWh++hLhsa-pp...h.....sthFP.pWphsp.tlshtFCchT+pcl.......t....tlhtp................ptp....ph..-...VplLL.slpcThpFEp.Lsc+F.................................................................................t........................................................................................Fp.thlSpsF-PaL.tlalctp-+pLtphl.phht....t.................................................................	0	109	172	243
+982	PF02204	VPS9		Vacuolar sorting protein 9 (VPS9) domain	SMART, Eberhardt R	anon	Alignment kindly provided by SMART	Family	This domain acts as a GDP-GTP exchange factor (GEF). It activates Rab GTPases by stimulating the release of GDP and allowing GTP to bind [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.18	0.72	-4.00	49	1496	2009-09-12 00:55:57	2003-04-07 12:59:11	13	121	301	10	1005	1449	9	105.40	25	12.44	CHANGED	hpputpcLppl.sph..poPp-Klphllpspchlhpsl................................tttstshuAD-hLPlLlalll+ups..pL..huslpalpp.........F........................h.psshhpu........EtuYhLTshpuAlpalcshsh	............................................h..tAhpcltpl...sph....psPpc.Klthlh.....pss...chIhpsh................................................................................................t..t.ppsp.shuAD-hlP.......lLl.Ylll.......+u............s...............pL..........huplpalpc.........F................................................................................h...tssh.hp.G...........E.tuY..hlTsl......p.uAlpalpph..t.....................................................	0	361	525	776
+983	PF03302	VSP		Giardia variant-specific surface protein	Mifsud W	anon	Pfam-B_4536 (release 6.5)	Family	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.42	0.70	-13.07	0.70	-5.83	6	1081	2009-01-15 18:05:59	2003-04-07 12:59:11	8	16	13	0	430	1062	0	178.50	20	59.27	CHANGED	CstCpsGYclSsDKTpCsuou..sCps-NCKsCSs-c+..psCp-CsSssYLTP.TpQCIDsCtKIGNYYssTsupsKplCKECssANCKTC-spGpCpsCsDGFYKsG-sCuPCcpsCKTCuuGTuSDCTcC.oGKsL+YGsDGTKGTCGtGCsTGsGuG.ACKTCGLTIDGsSYCSECAspTEYPQNGVCoSssuRAssTCpsuslAsGhCuoCssGah+MNGGCYETTKaPGKSVCpsAsuuG.TCQKtAsGY+LssssLssCS.GCKpCoSsTsCTsCh-GYVKo..osuCsKCDuoCcTCT.GusTsCcsCuTGYYKouospsuCTus-SD.pslTGVpsClsCAPPssspGSVLCYLIKDu...G.STNKSGLSTGAIAGISVAVllVVGGLVGFLCWWFICRGKA	...........................................................................................................s......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	430	430	430
+984	PF00092	VWA	vwa; 	von Willebrand factor type A domain	Sonnhammer ELL, Bateman A	anon	Prodom	Domain	\N	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.17	0.71	-4.55	189	10632	2012-10-10 16:07:06	2003-04-07 12:59:11	23	753	2209	191	4154	16265	2130	166.70	19	31.03	CHANGED	DllhllDuSsSlst.....tp.....app.s+palppllp.th.t.......hstpssplullpauspsp............h.hslssh..pstpphhptl...........tphhhhsusTp.hup.ALphshpphhpt..........ttssRt...sss+lllllTD.....Gpssss...tthstthppt................slhshulGh.......................psstppLpplu..s.tt..pphhhhpshpt................phhppl	............................................................................DlsFllDs...S..sS...lst.................................tp..............................a.pt.....h+...p...a.l..t.....p.llp..ph..p...........................hu..t...pp.s.+.......l.....u....l.l..p..a...u...s..p.sp....................................................s.h..p...ls..s.h.........p.s.t.p.....p.lhptl.................................................pph.h.h.h.u..u..s...T...t....s..u..t.......A..L...p...h...s..h...p.p.h.hpp.........................................tsR..........ps.s....p....l.......l.l.l.l...T.D.........................G...p......s.....s.......s...p.................h........t............h..t....thppt................................................sl.h.h.hulGh..................................................pss...p.p.L.ptls.........................h......................h...........................................................................................................................................................................	0	1087	1482	2603
+985	PF00094	VWD	vwd; 	von Willebrand factor type D domain	Bateman A, Sonnhammer ELL	anon	Dotter	Family	Swiss:P17554 contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.27	0.71	-4.06	62	4125	2009-12-18 15:39:34	2003-04-07 12:59:11	20	537	352	0	2288	3757	7	145.50	21	18.65	CHANGED	Csl.Gs..chpTFDGtpYsaps....ss.....sah..lspssssp..........hphhlt.ppsstsssth...h.pplplhht.............shplphtts.......htlhlsspplsh....shttssh..tlphhs........tshhhlth....thshpl..hphcs...tlhlplstthpspssGLCGsassctpsDhhpssGp	................................................................................................................................CtshGss.HahTFDG..t....has.F.G............sC....................pYh.......Lsps.s.ts.p................................phtlp..h...p.p...p..s.t....s..p.pt.h..............h.hpp.lpltlt............................................shplpltps................pl.h.l.ss.p.t.hth...............Pht.tsh.....tlphht................................t.t...hhlth........thshtl....h....p.h...s.......s..............pl......h.l.p..l...s.s............p....a....t......s....p.....s..s...GLC..G.sa.ss..p..p.sDhhh.ss...................................................	0	497	686	1444
+986	PF00095	WAP	wap; 	WAP-type (Whey Acidic Protein) 'four-disulfide core'	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.55	0.72	-3.99	72	1589	2012-10-02 12:37:03	2003-04-07 12:59:11	16	122	164	5	826	1565	1	44.60	36	19.27	CHANGED	KsGpC.P............tttt.Ch......ppC.psDpcCss.spKCC.........s.u.C.Gpp.ChtP	..............KsGtC.P.........................tttstCh.............ppC.....p......sDpcC..ss.....tp.....K...CC..........s..u.C..Gpp..ChtP...........	0	219	260	462
+987	PF00400	WD40	G-beta; 	WD domain, G-beta repeat	Finn RD	anon	Pfam-B_2 (release 1.0)	Repeat	\N	21.00	12.10	21.00	12.10	20.90	12.00	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.75	0.73	-7.90	0.73	-3.89	1804	193252	2012-10-05 17:30:42	2003-04-07 12:59:11	27	2206	1701	1549	125805	189768	5414	38.20	23	20.36	CHANGED	tphhtsh.puHpsslpslsasss........................sphlsouu..tDssl+lWc	............................................................................h......h.puH.p...s...s..V..p....s.l.s.asss.............................................................................sphlso..uu..............tDtsl+lWs...........................................................	0	44330	69386	100531
+988	PF00568	WH1		WH1 domain	SMART	anon	Alignment kindly provided by SMART	Domain	WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha  and mGluR5 bind a protein called homer, which is a WH1 domain homologue  [2]. A subset of WH1 domains has been termed a "EVH1" domain [3] and  appear to bind a polyproline motif.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.44	0.72	-4.34	8	1177	2012-10-04 00:02:25	2003-04-07 12:59:11	18	30	236	25	600	1088	23	104.80	28	24.22	CHANGED	huh......psIsouhAplahh-sss+c.Whhs....ppsusVshh+DsspNoYhlhuhclp.cscllhspplhsshpYspsoshFHpapsscs..hhGLNFuSE-EAspFtcthpcsl	...................................................tt...........slhp.s.hApVh....hh......-.ss.s....pc.....Whsh.......pthusVs..h.....h.....p......c......s......s.....p...s.........s...........a....hlhuhc.h...........p...sp...p............lllsp......p..l.h.......p..s.........h..p...Y...s....p.....s.....s........sp.....F....H..p..W...........p.s.....s.c.p...........haG...L..sFu..Scp-Ap.....p...Ftcthpc..h...............................................	0	159	234	397
+989	PF02205	WH2		WH2 motif	SMART	anon	Alignment kindly provided by SMART	Family	The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP Swiss:P42768 and Scar1 (mammalian homologue) to be the region that interacts with actin.	23.10	13.00	23.10	13.00	23.00	12.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.37	0.72	-4.21	57	1560	2009-01-15 18:05:59	2003-04-07 12:59:11	15	69	271	11	837	1462	8	26.60	38	5.24	CHANGED	ssssRuALLusIppG..t..LKKs.posD+S	.........sssRsuLLssI+pG....hpLKKs.pptp..........	0	213	324	544
+990	PF02467	Whib		Transcription factor WhiB	Mian N, Bateman A	anon	Pfam-B_2249 (release 5.4)	Family	WhiB is a putative transcription factor in Actinobacteria, required for differentiation and sporulation.	22.80	22.80	22.80	23.00	22.40	22.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.62	0.72	-3.67	8	2386	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	569	0	664	1645	791	66.10	42	61.73	CHANGED	WphpAlCRssDP-hFF.P..-RG..pusR-..AKclChR.CPVhpE..CtAaALcscctaGVWGGlSE.....cERRtL	.....................................WptpAhC...t.....p..t.....D....P.-....hFF...P.......ppG.........t.s..pcc.........AK...tlCtp.CP..Vppp....CLpa.....A......L........p......s....s........p......c......a........GVW...G...GhoE.......cERRtl........................	0	218	497	614
+991	PF02019	WIF		WIF domain	Bateman A	anon	[1]	Family	The WIF domain is found in the RYK tyrosine kinase receptors Swiss:P34925 and WIF the Wnt-inhibitory- factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge.  This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt [1]. The WIF domain is a member of the immunoglobulin superfamily, and it comprises nine beta-strands and two alpha-helices, with two of the beta-strands (6 and 9) interrupted by four and six residues of irregular secondary structure, respectively. Considering that the activity of Wnts depends on the presence of a palmitoylated cysteine residue in their amino-terminal polypeptide segment, Wnt proteins are lipid-modified and can act as stem cell growth factors, it is likely that the WIF domain recognises and binds to Wnts that have been activated by palmitoylation and that the recognition of palmitoylated Wnts by WIF-1 is effected by its WIF domain rather than by its EGF domains. A strong binding affinity for palmitoylated cysteine residues would further explain the remarkably high affinity of human WIF-1 not only for mammalian Wnts, but also for Wnts from Xenopus and Drosophila [2].	25.00	25.00	26.30	25.90	23.50	18.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.79	0.71	-4.71	10	223	2009-01-15 18:05:59	2003-04-07 12:59:11	13	21	84	5	144	241	0	122.70	35	26.76	CHANGED	laIsccEV++Ll......GlsA-lYYl+sGtlNsYuhc.....F......hlsVPS-VsslsFTWpS.uppcYhYuFsl.hosDpplLstPslsIsppGcVPpshpsFulsL.CoGspuGpsshslsLplpsscsh..ssTsLph+p+KhC	...................als..ph.hhh......G..l.p.t-..lahVcpGhlspashs......F........hhslPuplpplpFT.Wp.uh.u....ph.phhYshps................s.c.............tshhstPplNIshpGpVPp....p....hp.sapV....tLsCo.Gphsupsshplpl.lpsspt....ssThLph+ppKhC..................	0	30	41	95
+992	PF03106	WRKY		WRKY DNA -binding domain	Bateman A	anon	Pfam-B_85 (release 6.5)	Domain	\N	21.00	21.00	21.00	21.10	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.07	0.72	-4.13	34	3051	2012-10-02 23:28:20	2003-04-07 12:59:11	10	33	220	3	1178	2878	5	54.90	54	20.61	CHANGED	hcDGYpWRKYGQK.VKGu.aPRSYY+CTps...sCssKKpVERustDsphs.hsYcGpHNHsh	...........sDGYp.WRKYG.QK.sl.KGsP......h.P....R....u..........Y...Y+...Cop......sCss+...K....pVp.......R...s.t.....p..........D......s....p......h......h.........hsTYcG.pHsH..............................	0	150	687	953
+993	PF02206	WSN		Domain of unknown function	SMART	anon	Alignment kindly provided by SMART	Family	\N	19.50	19.50	19.50	20.10	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.99	0.72	-4.23	36	345	2009-01-15 18:05:59	2003-04-07 12:59:11	13	36	5	0	343	301	1	68.00	24	6.39	CHANGED	ssLpphhcphphluRlsNuIsLQtulhssoIshc-lluELLphsss.shsplhslcs...spltptlpplpch	...........hpphhcchphlARlsNuIsLQsulhs.sol.shcclIuELLslssh..phsplhshc........pplpphlppl...h................................	2	57	110	343
+994	PF00397	WW	WW_rsp5_WWP; 	WW domain	Finn RD	anon	Prosite	Domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.62	0.72	-4.06	547	8927	2009-09-12 21:03:02	2003-04-07 12:59:11	21	403	357	119	5200	8316	391	30.00	36	6.13	CHANGED	hsss.W.p.thh...ss.....GchY.YaNppTppopW-cP	..........LPsG.W.c.pphs..sp....GchY.YhscpT+.pTpWccP.....	0	1588	2359	3759
+995	PF02825	WWE		WWE domain	Aravind L	anon	Aravind L	Family	The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.29	0.72	-4.55	14	1021	2009-01-15 18:05:59	2003-04-07 12:59:11	15	76	133	6	601	935	23	72.80	24	8.55	CHANGED	hststtshhW.ap....sssspWpsYs.ps..pppIEsuaptpcp.....hlp.l..shhGtsYhlshpsMpQhpptss.....thRtV+R	.........................s.......hhWpap..........scpup...WpsY......s.........tp.s...........spp.........lE.p.uap.pspp...............sls...h............ss..t....t...h...t.Yhlc.....hps..M..p...Qhsppos............ptRtl+R......................	0	158	223	410
+996	PF02706	Wzz	wzz; 	Chain length determinant protein	Bateman A, Mian N	anon	Pfam-B_1977 (release 5.5)	Family	This family includes proteins involved in lipopolysaccharide (lps) biosynthesis. This family comprises the whole length of chain length determinant protein (or wzz protein) that confers a modal distribution of chain length on the O-antigen component of lps [1]. This region is also found as part of bacterial tyrosine kinases such as Swiss:P38134.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.63	0.71	-4.39	38	7377	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	3167	41	1494	5501	1022	184.60	16	39.45	CHANGED	scIDLhcLlttLh+p+hlIlhlsllhshhuhhYs..hhssPpYousshlhVspppt..........h...........sl.ssh......p.hs.shhcllpSppllpclhpclplt........................................................................................................................t.lpp.lsl..s.tp.potllslshp.spssppspplssplsps	.........................................................pl-lhpl....ht.h..l.......hc.......t....ph.h.l.l.hh.s.h.l.h...s..h...l..u.h....h.h...s....h..........h.......h..........s.....s.p...Y..pus..u..h....lh...l.tppstt...................t............t...........s.h....s.st...............................p..h.hs....s..h..h...p..ll.p....S....p.........pll....p....cs..h.p.p..h.slth.............................................................................................................................................................................................................................................................................................................................................................................pt.l..p.p...t..l.pl.....p......................t....po...t...l..l....s..l..s.hp....sps..p..s.t.plhsth...h.............................................................................................................................................................................................................................................................................................................................................................................	0	472	948	1240
+997	PF03254	XG_FTase		Xyloglucan fucosyltransferase	Bateman A	anon	Pfam-B_3419 (release 6.5)	Family	Plant cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins. Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. This fucosyltransferase adds this residue [1].	20.40	20.40	20.70	20.50	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.64	0.70	-6.00	29	257	2010-01-08 15:56:59	2003-04-07 12:59:11	8	7	32	0	171	248	4	376.80	37	79.45	CHANGED	lllu..............ptthsshhspttsssss.hspssptspD....+LLGGLLusGFDEpSClSRYpSu.LYRK.sSsa+PSsYLlSKLRpYEsLHKRCGPGTcuYp+AlcpL...puu....pssuss.....-.CpYlVWlshpG..LGNRhLolASsFLYALLTcRVLLVD...up-hu-LFCEPFPsTSWLLPh.DFPlps...hpuasppsscsYGsML+scsIsss...............t...PsalYlHLsHshpc..tDKh.FFC-c-QshLc+VPWLll+oDsYFlPuLFLlPuFppELs+LFPpK-oVFHHLuRYLFHPoNpVWGllTRaYpuYLA+ADERlGIQlRVFsppsssappVhDQIluCTpcE+LLPcl..sspps..........ssssupss+.KAVLlTSLh.stYaEpl+sMYWc+PTsTGElluVaQPSHEchQppspphHstKAhAEhYLLSLoDslVTSuhSTFGYVApGLGGL+PWlLacPps..tpsP..sPPChRuhSMEPCFHsPPhYsC+u	...........................................hh.s....................................-....tLhsGLL..s.s..s..h.s.ct..oChSRapt..h.a...h+.................h.....sSsaLlp+LRpaEthp+.+CGPtTt.YppshppL.pps..........t.t..sss......t..C........pYlVh.h......s...h..p.G..LGNRhLshsSsFLYAlLTsRVLLV.....c........st.c.h.ssLFCEPFPs......o.oWhL..P.................c..F..Phtt...........httht...tt.csa.sshlpp.phht.ss.................PsahalpLtts...t............-.p.h.F...aC-csQ..th..L.p..plsW.ll.hp.oD..YasPuLF........hhPtappE.Lp.phFP.p..+-.sVFHaLuRYLhHPsNplWt.hlp+.a....apuY.Lut.u.s.cp..lGlQ.lRh...a..t......t.....s.......h..p.h....hc.Qlhs.Cs.pc.p.lLP..pl....tttt....................sst.tstp.puVLlsSL..s.Yh-pl+shYhp.............pssh..sG.....-..h.ltVaQ....PSH.....EthQ.p.tpp.Hs..KAhAEhaLLShsDhl.lTSu.hSTFGYVA.pGLuGlpPW.lhh.p..t........ttss.....p.ssChpshShEPCha.PP..htCp....................................................	0	33	90	137
+998	PF05181	XPA_C	XPA;	XPA protein C-terminus	Studholme, DJ	anon	PF02186;	Domain	\N	25.00	25.00	25.20	25.40	24.20	24.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.47	0.72	-4.37	16	261	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	237	2	182	251	2	51.70	54	16.42	CHANGED	-KYSLLTKTEsKpDYLLTDsELcDcE.LLs+LtKsNPHpusaucMpLaLRhQV	......-KauLlTKTEAKp-YLLpD.......s-LcccE..lL.altK.NPHpupWucMpLaL+hQV.....	0	58	94	146
+999	PF01286	XPA_N	XPA; 	XPA protein N-terminal	Finn RD, Bateman A, Studholme, DJ	anon	Prosite	Domain	\N	27.10	27.10	27.10	27.40	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.95	0.72	-4.27	10	119	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	95	2	72	115	0	33.60	52	11.78	CHANGED	.-Y.hC--CsK.FMDSYLhspFDhsVCDsCRDs-	....sashCcECu+pFhDSYLhspFDlslCDsC.RDs-....	0	23	31	52
+1000	PF00102	Y_phosphatase		Protein-tyrosine phosphatase	Sonnhammer ELL, Griffiths-Jones SR	anon	Swissprot_feature_table	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.81	0.70	-5.02	114	7626	2012-10-02 20:12:17	2003-04-07 12:59:11	22	291	589	328	3916	9772	240	210.40	29	34.46	CHANGED	NhpKNRatslhshDp..oRVtL.................................t..s.sD..Y..INAsal....................uht.t...tppaIsTQuP.......l..................pTh...pDFW+Mlapp..p.spsIVMLsphhEt.........sp......KCspYWP.........pp..shpaGs.hpVphh.......ppp.tptshhl+phplp.....p....tspp...............................ppl.ppapap....sWP..Dps.......lP..ps.....spshl....phlcplcptp...................tsPllVHCS.....AGlGRTGsalslchhhpplcp.......pth...lclhp........hlpplR.ppRsthVQo......pQYhFlapslhc	.................................................................................................................................N..KN.Rh......s.l...h.........s..h......-..p..sRVhL.............................................................................................................t.....s-.......Y.....I..N...Asal..........................................................pshp..p.........ptaI..so...Q......u..P...............l...................................................pTh.......tDF..WpMlacp....................p......s..t......h................I.VMlsph..Eh......................................sp...............KC.tpYWP.................................pt..........shp.a.....s....t......h.p.Vphh...................ppp....hsp.a..hhR..p.h...pl.p.....p.......tppt........................................................................................+pl....ppa.pah........s.W.....P....-pu................................................lP......pp...............spshl............phl.p.p.lpptp.............................................................................ttsP..l...l.VHC..S............................AG.sG.R........T.G.....s...a...h...s......l.s..h.h.h..p..t..hcp...........pth.........................lslh.p.......................................................hl..p.p..hR...p.p...R.s..t.h.lp..o.........................pQ..Y.Fhapsl.......................................................................................................	1	1277	1669	2915
+1001	PF04893	Yip1	DUF649; 	Yip1 domain	Finn RD, Bateman A	anon	Pfam-B_5598 (release 7.6)	Domain	The Yip1 integral membrane domain contains four transmembrane alpha helices. The domain is characterised by the motifs DLYGP and GY. The Yip1 protein is a golgi protein involved in vesicular transport that interacts with GTPases [1].	30.90	30.90	30.90	30.90	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.47	0.71	-4.76	208	1661	2012-10-01 22:34:14	2003-04-07 12:59:11	12	30	827	0	929	2057	257	174.80	14	66.95	CHANGED	lhhpPsph.appltppt..........................hhhhhhlhshlshlhshhhs.........h...h.........................................hthhshhts......hhshhlhh.......hlshhlhuhlhth.......hsphhs.......upss....htp....shslhuas...hhPhhlstlhshhhhhhh.........................................hh.hhlhshWsh..hlhhhulttshphsth..puhhhshh.......shllhlh	.......................................................................hp.tth.hpchht.hh.........................................................tp.cLh.uslh..hs.l..shshhlhhs...................................................................................th.h.shhuh................lhhshh...........hlshhlhshlhhh.....................h......hs...................ushs.....ahp..............shs.l.h.GYs....hlP.h.s.lssll.sh.hh..hhh.h........................................hhh..shlhhhWsh....hhhshhh.tthh..t..h........t.hh....................hhhhh........................................	0	325	549	754
+1002	PF03226	Yippee-Mis18	Yippee;	Yippee zinc-binding/DNA-binding /Mis18, centromere assembly	Mifsud W	anon	Pfam-B_2930 (release 6.5)	Family	This family includes both Yippee-type proteins and Mis18 kinetochore proteins.\	Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus [5].	24.80	24.80	24.80	24.80	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.82	0.72	-3.94	54	862	2012-10-03 11:08:31	2003-04-07 12:59:11	9	10	301	0	600	712	1	97.00	39	59.44	CHANGED	hVFpCtpCpshLuDShshls.......pspp........psllh......................p...plsssVhlscphhsup.p.t......sshpslhCptCstslGhhYhsospp.hshhcshFslphcplpsYp	.........................................................p.hasCtpC+scLusps-lIS+.....................shpGtps.......+AYLF...................................................................sp......llNls.pu....s...p.-RhhhTGh.............HsVsDIhCpsCpstLGWKY-.....pAhEpoQKYKEGKaIlEhtth....h............................	0	172	307	445
+1003	PF02757	YLP		YLP motif	Ponting CP	anon	Ponting CP	Motif	The YLP motif is found in several drosophila proteins. Its function is unknown, however the presence of completely conserved tyrosine residues and its presence in Swiss:Q15303 may suggest it could be a substrate for tyrosine kinases.	25.00	5.00	25.00	5.10	24.60	4.90	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.31	0.76	-5.60	0.76	-3.38	26	674	2009-01-15 18:05:59	2003-04-07 12:59:11	12	40	12	0	397	674	0	8.90	65	15.78	CHANGED	usEYLPPsp	..usEYLPPsp..	0	60	60	245
+1004	PF04146	YTH	YT521-B; 	YT521-B-like domain	Bateman A	anon	Pfam-B_1386 (release 7.3)	Domain	A protein of the YTH family has been shown to selectively remove transcripts of meiosis-specific genes expressed in mitotic cells [3].  It has been speculated that in higher eukaryotic YTH-family members may be involved in similar mechanisms to suppress gene regulation during gametogenesis or general silencing.  The rat protein Swiss:Q9QY02 YT521-B is a tyrosine-phosphorylated nuclear protein, that interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68. In vivo splicing assays demonstrated that YT521-B modulates alternative splice site selection in a concentration-dependent manner [1]. The YTH domain has been identified as part of the PUA superfamily [4].	21.40	21.40	21.40	23.30	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.53	0.71	-4.58	59	968	2012-10-02 17:37:24	2003-04-07 12:59:11	10	23	252	2	553	870	5	142.90	42	23.91	CHANGED	su+aFlIKSho.t-slctSlchslWuoospss........c+LspAacpsp..........sVaLh.FSVNtSGpFtGhAcMhos.lshs...................................................................................................pss.hW..................................................................tp....casGs.FplcWlhlc-lP.pph++l.......hss...-s+sVphuRDspElp.phGhpllplFcph	........................................................................................s.sRaFlIKSho..c-cl+cSl+as.lWsST..psN........++LssAa.+psp...................sVaLl.......FSVNsSGcFsGhAcMtos.lcas.....................................................................................................................................................................................................................................ps.sshW....................................................................................................................................................................................................tt.......t+WsGh.FcVcWl..hl.+DlPssph+Hl.......p.p..N-N.....KPVstSRDsQEl..hc.pGtpllplht..h.........................................................................................	1	150	268	403
+1005	PF00643	zf-B_box		B-box zinc finger	Bateman A	anon	Prosite	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.88	0.72	-4.06	106	7772	2009-09-12 06:38:22	2003-04-07 12:59:11	19	359	385	16	4488	6434	9	43.10	26	9.16	CHANGED	pptthC..spHp.....p.p...hphaCpsCpp.hlCppChhtt.......H..ps......Hph...hsl	........................t....hC...spHp................c..p.....hphaCp..s..s..pp..hl.....C.h.h..Cphst.............H..ps...................Hphh...............................	0	1713	2306	3263
+1006	PF02892	zf-BED		BED zinc finger	Bateman A	anon	[1]	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.41	0.72	-4.20	41	1403	2012-10-03 11:22:52	2003-04-07 12:59:11	10	85	169	2	872	1516	7	47.30	26	9.97	CHANGED	utsWcaFphhp.......tcppspCpaCtKthstt.........GTosLpcHL........hptpp	.......................s.lWpaFphht.............tpppspC.......ph..C..p...ptlstt..........uTo.s.LppHL..........ptp.......................	1	185	394	653
+1007	PF01530	zf-C2HC		Zinc finger, C2HC type	Bateman A	anon	Swiss-Prot	Family	This is a DNA binding zinc finger domain.	25.00	25.00	26.10	27.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-7.84	0.72	-4.22	33	1621	2009-01-15 18:05:59	2003-04-07 12:59:11	13	44	89	6	769	1357	1	30.90	62	11.87	CHANGED	thpCPTPGCcGpGHlsG.pas....sHRSluGCPhu	............h+CPT.P.GCDGpGHloG.pas....oHR...SL..SGCPhA..	0	116	177	407
+1008	PF00097	zf-C3HC4		Zinc finger, C3HC4 type (RING finger)	Sonnhammer ELL, Vella Briffa B	anon	Swissprot_feature_table	Domain	The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid [1]. Many proteins containing a RING finger play a key role in the ubiquitination pathway [2].	21.00	20.70	21.00	20.70	20.90	20.60	hmmbuild  --amino -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.37	0.72	-4.30	35	9094	2012-10-03 15:03:13	2003-04-07 12:59:11	20	329	3245	29	3178	27732	1125	40.40	44	7.09	CHANGED	CslChchhppss................hhtCtHs.FCpsClpphhp........tptht..CPhC	...............................................CpIC...p...c.l..l...s..-Pl.......................................................pos.C......p........Hh....FC.+....s.....CIh.ctlc.............................hhssh.....C.PtC...................................	0	1053	1488	2303
+1009	PF00642	zf-CCCH		Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.40	0.72	-4.21	88	7686	2012-10-01 21:35:20	2003-04-07 12:59:11	19	244	456	18	4636	7265	193	26.00	35	7.49	CHANGED	hcpthCphatcsG..tCpaGspCpFtHsh	..........p.hCpha..h.c.G.....tC.paG.s.p.Cp..FtHs......	0	1486	2495	3614
+1010	PF00098	zf-CCHC		Zinc knuckle	Bateman A, Eddy SR	anon	Overington and HMM_iterative_training	Domain	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag  proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.	20.80	16.70	20.80	16.70	20.70	16.60	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.41	0.73	-6.48	0.73	-3.78	184	50986	2012-10-03 11:39:54	2003-04-07 12:59:11	18	692	722	56	6654	45194	253	17.90	58	7.29	CHANGED	tpCapCGp.GHhu+-Csp	....htCapCG.KEGHht+sCpt....	0	2202	3537	5115
+1011	PF02008	zf-CXXC		CXXC zinc finger domain	Iyer LM, Aravind L, Bateman A	anon	Bateman A	Domain	This domain contains eight conserved cysteine residues that bind to two zinc ions.  The CXXC domain is found in a variety of chromatin-associated proteins. This domain binds to nonmethyl-CpG dinucleotides. The domain is characterised by two repeats [3], and shows a peculiar internal duplication in which the second unit is inserted into the first one [4]. Each of these units is  characterised by four conserved cysteines, displaying a CXXCXXCX(n)C motif that chelate a Zn+2 ion. The DNA binding interface has been  identified by NMR [3]. In eukaryotes, the CXXC domain is found in stramenopiles, plants and metazoans. Plants possess  a mono-CXXC domain that is present in distinct chromatin proteins  [4]. Structural comparisons show that the mono-CXXC is homologous  to the structural-zinc binding domain of medium chain  dehydrogenases [4].	21.10	21.10	21.80	21.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.87	0.72	-4.15	31	1021	2012-10-08 21:21:50	2003-04-07 12:59:11	15	77	106	16	505	970	22	46.30	45	4.85	CHANGED	pshp+pp+.CGhCcuCpps-.CGpCssCpD...hhKaGGsspp+Q.pChhR+C	.........t.t++ppR.CGpCp.uCpps-sCGpCshCpD...hh.KF.G..Gssth.+Q.pCh.hRpC.........	0	110	148	279
+1012	PF01529	zf-DHHC		DHHC palmitoyltransferase	Bateman A	anon	Pfam-B_945 (release 4.0)	Family	This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.00	0.71	-11.65	0.71	-4.87	97	4432	2012-10-03 10:42:43	2003-04-07 12:59:11	15	126	347	0	2951	4268	82	169.10	23	40.72	CHANGED	hhsahhshhssPGhhspt.................................................................................................................................................................................................................................hhtss..tttptpaC.p...........Cphh.+PsRs+HCphCspClhchDHHCsWlssClGtpNa.+a.F....h.......hF...........lhhhslhhhhhhh.....hthhhhhphhtptphh.hhhh...........................................................................................................lhhhhhs........hhhhlhhshlhhh.........phh.hhh.ps...hT....ohEhhptt	...................................................................................................................................................................................................................................................................................................................................................................h...........Pu.......................................................................................................................................................................................................................................................................................................................................................tt..............thp...a.Cpp...............C..p........h.......h..+P.........s....R.u.+HC...p.....h..C..s......pCV..h.+h.D...H..H.....C.s..W.....l.s.NCl...G.............tp....Na..+a..F..h..........hF..................................lhh...h.s..l.h....s.h....h..h....h.h........h.s.h....h......h....h...h....t..h....h....t.....t....t.t...........t..h....h..h....................................................................................................................................................................................................................................................hhhhh.hs................hhh.hh.h...l.s...h....l..hhh...............phh.hlh..ps............T....ohE.h...t.......................................................................................................................................................................................	1	1087	1605	2335
+1013	PF04438	zf-HIT		HIT zinc finger	Bateman A	anon	Bateman A	Domain	This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein Swiss:P46973. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) Swiss:Q15649 that specifically interact with the ligand binding domain of the thyroid receptor.	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.11	0.72	-4.30	100	1073	2012-10-03 05:12:49	2003-04-07 12:59:11	11	21	308	3	734	1067	14	30.60	38	9.10	CHANGED	tpphCsl..Ctp.....u+YpCPpCsht........hCSLpCh+	..................hCsl...Csp.....u+Y.pCs+C.sht........hCSLpCh+.....	0	221	385	573
+1014	PF02891	zf-MIZ		MIZ/SP-RING zinc finger	Bateman A, Mistry J, Wood V	anon	Psi-blast Q9UN16	Domain	This domain has SUMO (small ubiquitin-like modifier) ligase activity and is involved in DNA repair and chromosome organisation [2][3].	22.20	22.20	22.30	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.07	0.72	-4.45	36	975	2012-10-03 15:03:13	2003-04-07 12:59:11	15	16	294	1	586	1031	4	50.20	45	7.21	CHANGED	lSLpCPlohpRlpl..PsRuptCpHlQCFDhtuaLphspptss....WpCPlCsps	............lSLhCP..ls...t.h.Rl.pl..PsRutsC.pHl.Q..C.FDh.phaLphNp..cp.so...........................WpC..PlCsK.t................	0	192	294	443
+1015	PF01753	zf-MYND		MYND finger	Bateman A	anon	Bateman A	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-9.03	0.72	-4.08	177	3934	2012-10-03 05:12:49	2003-04-07 12:59:11	13	252	370	26	2780	4039	204	41.10	35	7.26	CHANGED	C..shCtp.....................tshp..pC.spC...........p...ts....hYCSppCQptcW.t......t....H+p.C	...................................................Ct.Ctp...................................tshp.......pC..stC..............p......ts........hYC...u...ppCQ.p.tcW..t............t.......H.+p.C...................	0	1218	1661	2317
+1016	PF05020	zf-NPL4		NPL4 family, putative zinc binding region	Wood V	anon	Pfam-B_13681 (release 7.6)	Family	The HRD4 gene was identical to NPL4, a gene previously implicated in nuclear transport. Using a diverse set of substrates and direct ubiquitination assays, analysis revealed that HRD4/NPL4 is required for a poorly characterised step in ER-associated degradation after ubiquitination of target proteins but before their recognition by the 26S proteasome [1]. This region of the protein contains possibly two zinc binding motifs (Bateman A pers. obs.). Npl4p physically associates with Cdc48p via Ufd1p to form a Cdc48p-Ufd1p-Npl4p complex. The Cdc48-Ufd1-Npl4 complex functions in the recognition of several polyubiquitin-tagged proteins and facilitates their presentation to the 26S proteasome for processive degradation or even more specific processing.	20.40	20.40	20.80	20.60	18.60	19.80	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.90	0.71	-4.55	22	277	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	241	0	198	293	0	135.90	48	23.39	CHANGED	pVpp.slDshL-KpDGhIpRp+.ophC..+HGsKGMC-YCsPL.PaDcpYhpEpp..IKHlSFHAYL+KlspspNK.t.GoSalsPLppPsaplphsCssG.H.PWPcGICoKCQPSAITLQpQpFRMVDHVEFtsssllspFlshWRpTGs	................................................................s.V.pstlDphLsKpDGpI.Rp+Dsp.h.C..+HGspGhCs.aCh.PL..-Pa.DtpYLp-pc..IKHhSFHuYlRKlsuus..sK.............Gp..hh....sLpp...sh+l+psC.s.......H.PW..P.cG.ICoKCQ....PSAITLppQpaRhVDplpFpsssllspFLsaWRpTG.....................	0	67	103	162
+1017	PF04810	zf-Sec23_Sec24		Sec23/Sec24 zinc finger	Bateman A	anon	Bateman A	Domain	COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.	23.10	23.10	23.10	23.70	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.35	0.72	-4.39	133	1393	2009-01-15 18:05:59	2003-04-07 12:59:11	10	29	324	26	939	1354	14	40.00	38	4.58	CHANGED	sPlRCp..pC+ualNPasphs...suppWtCshCtt.pNplPspY	...............PlRCp......pC+uYlNPa.sph.t.......pu+p..WtCshCtp.tN.plPspY......	0	313	517	760
+1018	PF02148	zf-UBP		Zn-finger in ubiquitin-hydrolases and other protein	Mian N, Bateman A	anon	IPR001607	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.77	0.72	-3.86	179	2273	2012-10-03 15:03:13	2003-04-07 12:59:11	14	45	510	19	1416	2222	31	68.20	29	11.39	CHANGED	C.....spCs............................s..ps..................lWl....CLp..CGpluCG.....R.p...........s..sHAhpHa.p.pss.....................................Hslslslsshp........l.aCYss..-shVp..s.ph	..................................................................................C.ptCt...................................sp....ts.......................lWh....CLp..CGpluCG.............R..........................p.sHAhpHh.p...psp...........................................................Hslslslpshp...............................l..aCYss..cp.Vhp..h..................................................................	0	429	703	1082
+1019	PF04704	Zfx_Zfy_act		Zfx / Zfy transcription activation region	Kerrison ND	anon	DOMO:DM04798;	Family	Zfx and Zfy are transcription factors implicated in mammalian sex  determination. This region is found N terminal to multiple copies of a C2H2 Zinc finger  (Pfam:PF00096).  This region has been shown to activate transcription when fused to a GAL4 DNA binding domain [1].	25.00	25.00	25.30	25.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.01	0.70	-5.58	5	252	2009-01-15 18:05:59	2003-04-07 12:59:11	8	42	68	0	75	216	0	215.60	54	43.94	CHANGED	EsVlIEDVcCSDIL-EsDV.SEuVIIPEQVL-uDVA........EE-SLuphslPDplLTS-LlosololPEpVhsuEuVosss.GHlEpllpssVlttEIlsDPLstDlVSEEVLVADssSEAVIDA......SGlPl+ppDDD....KuNCEDYLMISLDD.uuKlDH-GuoslTMuA-uEpDs..SKlDGsuPEVIKVYIFKADu-ED.DlGGTlslVESEs-NcHtssVhDspsSuRlPREKMVYMsVsDSQQEEDDLssuEhsDpVYMEVIVGEEDAu.......stHEpQM-DSElpKTFhPlAWAAAYGNNo.DuIEsRNGTASAhLHIDESsGLsRlsKQKsKKRRRGEoRQYQ	..............tl...-sVps.-IhtEs.l..o-.....sVIhP-tlLt.s-Vs.........-.sL...t........c.lLsu-lhtt....s.........thP-pVhss-.hp...................................................hsp...-slhp...............................tlslp..p..p.................cssspDYLMI.ShD-.s.Kh.......s.hphtst.......t....p.pt.s.E.VIK.VYIFKA-st-D..-lGGT..lsES-.pssH....tlhs..s.p.Rh..REKMVYMsVpDSp.E-..-.-........................htpcpt...............................p.hpts........s....hhh.hs................u................Ns....ssl.Es+sssAuthLpIs-uhshs+lhKQKsKK..++Rs-s+QhQ................................................	0	3	9	28
+1020	PF02535	Zip		ZIP Zinc transporter	Bashton M, Bateman A	anon	Pfam-B_1189 (release 5.4) & Pfam-B_1903 (Release 7.5)	Family	The ZIP family consists of zinc transport proteins and many putative metal transporters.  The main contribution to this family is from  the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant [1].  Also found within this family are  C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.	28.30	28.30	28.30	28.30	28.20	28.20	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.02	0.70	-5.42	40	6416	2012-10-02 19:55:49	2003-04-07 12:59:11	17	54	2513	0	3060	5517	747	223.60	18	74.42	CHANGED	h.thhlhulhslhlsohhushhshhh.hhtt............................t..phhlphlhsFuuGllLusualHlLPcuhcshtpt.pht.............................................shsshhshhGhhhhhhl-phhphhhtt............................................................................t..t.....t..........t.t..............................................................................................................................t..htptptcpptpspppsppphtpthp.t....................uhllh...............huhslHslh-GLAlGsotsssp...shslhlAlhhHcl.cslGlsuhLlpushsptpshl...hshlhulssslGhslGlsl.........tustuthspull.uhoAGhhlYlull-llspthtpsp...........................h..lhphlsllhGhulMslls	.........................................................................................................................................................................................................................................h.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t................................................................sh.h.hh......................................................................hu.l.s..lHs..h....-G................l..A..l...u.....s........s.......h.t.....ss..................uhslhlu..l..h..h......Hp...hscuh..u.............ls......h...l...h..............t....s...........s....h...........s....t.....h............p.....s..hh.......hshh...u..l......s...................p.sl.G..sh........l.u.hhh.................................s......................h....s..............h...h....h.............s.................h..............h..........h..........u...h...sAGh..hl...al.s...h.-...l.l...s....p.th.t..tp......................................................hh....t..h.h..s.h....h....h.Ghhlhhh..s.............................................................................................................................................................................................	0	1027	1736	2521
+1021	PF00246	Peptidase_M14	Zn_carbOpept; 	Zinc carboxypeptidase	Finn RD, Bateman A	anon	Prosite & Pfam-B_4832 (Release 7.5)	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.07	0.70	-4.80	114	5755	2012-10-02 19:46:12	2003-04-07 12:59:11	19	114	1951	160	2797	5760	1277	247.20	18	49.68	CHANGED	lhsalcpls..tphPsls..phhsl.Gp.Sh-GRslhslclopt...................................tss+sslhlpushHupE..hluptsshhhl.....ppLlpt..............pstthppLlcphchallPshNPDGathst..p.......................................ttphWths........Rssst..............................GsDLNR.........N.....a........sht.h.........s.sspssssp.atu.ts.t..............pPEspulh.sa.l...pp...........tphthalslHuhuphhh.........aPas.............................hsh..........................shsssppp........hpplupthspshtp.ht.............t....a..phG.ssss............hY.ss.GuspD.....asa.phsh.......hsaThEltsps.......................hhhss.....spl..tsp-shtu	......................................................................................................s..t...h.h......p...h.....l..G.p.....o........h...........p........s......p.................l..h.lplst.....................................................................................................ttsc...t.l.h.l.u..shH.u.p.E..hhus..t..h.hh.hhl.................p.p.Lhpt...............................ts....th...p....t.ll..c..p..h.phh...llPsh..NP...DG.ht.hst...........................................................................................................R.ss.ss.....................................................................................Gh.DL.N.R.............................s....................a..........................s.............................................................................s......................................................psEspulh..ph...h....pp.........................................hphthhlshH..u...h.....s.thh...............h.a..s............................................................................................................................................t........................................s...t...........................h...h.t.......h....h.......................................................t......................................................t...p...............h.h.....th.................hthth................................................s.........................................................................................................................................................................................................................................................................................................	0	956	1446	2182
+1022	PF00100	Zona_pellucida	zona_pellucida; 	Zona pellucida-like domain	Sonnhammer ELL, Bateman A	anon	Swissprot_feature_table	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-12.48	0.70	-4.95	143	2880	2009-09-12 10:41:20	2003-04-07 12:59:11	18	163	237	17	1681	2596	0	221.40	16	41.22	CHANGED	pCsp.sph.........pltlpps.h.ts..............th.phsplpL.......pssp...........Cps.............hpsssshhhaphslss.........CGop.ppp...............hhYp..Nplhhphps..........................t.lhp.....hphtl.pChY........................ppshts..sh...................................h..thss...hs......s.sshp.........hphplhs..........................s..htp......................phss.h.lspsla.lc.....sphhs...........h.l........hlcsChA..Tss...s...s.spasll..ppGCs.pscshhsh.h...............htsphtcFp.hpsFpFs.........................spsplalcCplplCtssp......Cpt......Cstt	...................................................................................................................................................Ct..sth..l.lthp.....................th........phhh.............tt.t..................C.s...............t.st..t..h.h.h.h.ph.shpt............CGsh.thp.........................................t.........hhap....stlhh...t....ts....................................h.h........hthth.pCta........................................th...h.........................................................................................................s......................t.s.ht..............hphph..hp..............................st.................................t.sh.htlsp.lh...hp....h...hp..p..............s.h.l......................hlppChA.........sss............st.................phtll......tpG........Cs....tp.h.th........................................tsphhphp..hpsFpFs...........................pts.lahpCpltl.C.ttt.......C..........C...t.......................................................................................................	0	525	708	1302
+1023	PF01262	AlaDh_PNT_C	AlaDh_PNT; 	Alanine dehydrogenase/PNT, C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_4166 (release 6.6)	Domain	This family now also contains the lysine 2-oxoglutarate reductases. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.66	0.71	-4.69	96	5257	2012-10-10 17:06:42	2003-04-07 12:59:11	16	38	3489	97	1531	6780	5369	153.50	35	34.75	CHANGED	hpchttthshLhsussuVtP...A+VlllGuGVsGhsAhphAtsLGA.VsshDhpssphcpl-slhuphlps..................................hhsstttlpctltpsDllIsssLlPGpcAP+LlocchlppM+...................PGSVlVDlAl-pG.......GshEsocsss..................sshshpGVhhhu	....................................................................................h..p.tthhshhl.su...ss..s.V....s....P.....u+.V.h.l.l..G.u.G..VAGh....s..AhthAtu.L.G.A...........V....p.s.h......D..h..p......s.....p...t.h.c.p........l..c..s.........h..........h.........u........p..h.lps..................................................................................hh......u.....p......t......h.l...t..ptlp.cs..DllIsssLI.P...G..t.tAP+...L.....l.....Tc-M..Vps.MK.....................................sGSVlVDl.Ah.-..p..G...........GshE.h.o..c..ss.p....................................ss.h.h.t.pG.Vhhhu....................................................................................................................	2	518	968	1302
+1024	PF05222	AlaDh_PNT_N		Alanine dehydrogenase/PNT, N-terminal domain	Finn RD	anon	Manual 	Domain	This family now also contains the lysine 2-oxoglutarate reductases. 	29.50	29.50	29.80	29.50	29.30	29.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.44	0.71	-4.16	363	5191	2012-10-02 14:31:05	2003-04-07 12:59:11	10	33	3449	95	1522	3903	4047	132.80	37	29.97	CHANGED	GlP+E.hps...t...EpRVAlTPssVppL.....hpt.G.a..cVhVEsGAGh...uuuasDpsYptA...GAplss.ss.tp........lastu-lllKV+pP.........ssEhshl+pGphLhoaLahu...s.s.phsctLhppsloulAhEslsc.h..cu.slslLusMuplA	...........................GlP+E..hps..s...Ep.RVAhTPssVcpL...........lpt...G...a...pVhVEsu....A..G.....suuFsDp.sYtp.A.....GApIls...ss...c.......sas.u-lllKV+pP..................ssE.....hshl..........+p.....G.......thLho..aLa.A.......s.s.plhc.........tLh....p....p.........t........l..........o......s.lAhEsVsc...p........cup..sLshLusMuplA...........................	0	510	963	1296
+1025	PF05218	DUF713		Protein of unknown function (DUF713)	Moxon SJ, Pollington J	anon	Pfam-B_6651 (release 7.7)	Family	This family contains several proteins of unknown function from C.elegans. The GO annotation suggests that this protein is involved in nematode development and has a positive regulation on growth rate.	21.20	21.20	21.20	21.30	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.55	6	53	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	5	0	50	59	0	174.90	23	27.54	CHANGED	EELcchRpppKp+hhAFasClcLKhRFEEKEp-WuDWIpss.+pPIhRlhphFppF.ppht.....a++hsp-p.s-..lppEIhhlppclhshhsoLpphFppLppLppcap-sLFIKVLpKsIs-hAs+.......LhplhNsLsc...ssS+-.appLcshFppIssssIPoTopLR+ICKpsshSD.YpslcFPKl	...................................-hpph+pp.ptphth....hhpClhL+h+FEE+EccWucWlpsh.RpslsplhppahpFppphp..........hpc.hsp.c..cppp.....l.p.Eht.htpplhsshstlppsappLcpLpppasDtlFl+lL......Kslsphusp..................Lhplhptltph.....thspp....hp..pLcphhtplcs.ppIPoTspL+phspss.p.p-.Ypslp.s..h.....	1	9	9	50
+1026	PF05210	Sprouty		Sprouty protein (Spry)	Moxon SJ	anon	Pfam-B_6527 (release 7.7)	Family	This family consists of eukaryotic Sprouty protein homologues. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [1]. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice [2].	25.00	25.00	25.40	25.40	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.29	0.72	-11.13	0.72	-4.04	18	429	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	86	0	238	353	0	107.50	48	29.34	CHANGED	+sRCt.C...RsL.Sphhss+.shCs.....ucsslcpsoChsCsculhYHChsDsEG-........huDpPCSCs.......cspsCsRWhuLuuLSLhlPCLhCYhPhRuCh+huptC.......GC..Ct	.................+s+Ch.C...........Rsh.sp..ss+.shCp......scsslchsoCMhCscuhhYHCh.s.DsEG-............................huD.PCSCs........................ps+hC......hRWhuhuuLSlhlPCLhCYhPh+uCh+hsptC.......GC..Ct....................	0	32	51	123
+1027	PF05216	UNC-50		UNC-50 family	Moxon SJ, Studholme DJ, Wood V	anon	Pfam-B_6607 (release 7.7)	Family	Gmh1p (Swiss:P36125) from S. cerevisiae is located in the Golgi membrane and interacts with ARF exchange factors [1].	21.10	21.10	35.20	28.40	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.58	0.70	-5.16	24	272	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	239	0	184	268	3	215.90	38	82.36	CHANGED	ssph.chhRRlFK.hppMDFEhAhWpMhpLhhsP++VYRshhY+KQ.....TKspaARDDPuFllLhshhLslouluauls.Ys..uhhp............hlphhlhhVhlDFlhsGlllATlhWhlsN+.aLp..........................hspsscpplEWuYsFDVHCNuFhPhallLYllQahLlPllh...ppsaluhhlGNoLahhulsYYhYlTFlGYssLPFL..................cssphlLh.Plsllhllallul.......hGaNlsthhhphYht	...................t.ph.pahRRLh+...hpQMDFEhAhWpMhaLh.h.sPp+VY+shhY+....KQ...........................TKspWARDDPAFllLlshhLslooluauhs.hs...uhhp............h..lphllhhlhlDhlhsGlllATlhWhlsN+.aht.................................hppstctcVEWu.......YsFDVHhNuF...aPhhlhLahlQ.hhhh.s....hlh.....tp.........s.........aluhhlGNoLahhAluYYhYlTFLGYss.LPFL...................cpT.p.hlLh..Phhh......lhll.ahl.s.l......hhG.aNhst.hh.hY...................	0	69	102	153
+1028	PF00702	Hydrolase		haloacid dehalogenase-like hydrolase	Bateman A	anon	Pfam-B_566 (release 2.1)	Domain	This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null --hand HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.66	0.70	-3.93	239	27368	2012-10-03 04:19:28	2003-04-07 12:59:11	21	179	5134	203	8521	48772	5819	255.00	26	31.25	CHANGED	hcsllFDh.sGTL..hpsp.hl.................................................................................ttthhphh..tph........shthh.http.............................................................................................................sttphhpphhtt...h.tt.hhttt..................................httttthhhhh...................................................................................................................................................................................tthhthhthtstlhs......s.........stpslpp..........L+pt........uh....plsllo.s.....s....hpshtpths..l............................s.hhhuph...................pP.psc..h...tthhcp......lt................p.t........p....shhlGDuh.sDh.uhttAs	...............................................................................................................................................................................................................................................................................................................................................................................................sslshDKT..G....TL.....T.p.s..c...hplt.....................................................................................................ht...........................................ths.pp...p...h..h...p..hs...........ssh........p.....t......h.......s......p.....p....P........h.....u...p..u......l....h...t..h....s..p..t.......t...........................................................hp.t.h..t..t..h..........s...h...s..h..t....s.t.h.pst.......................................................................................hh..........us....p.h.h...t..p.t.s...hp......................t........t.............................................ttt.s.t..s.s.h.h.hs..................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................s...h.p.h..l..G..l.l...u...l..t......D....s....l...+..s................s..............................s..t..p..u....l...p.p...................L.+.p.t...........................................Gl..................c.s.h.M..l.T...G.................D.s..t...t...T...A...p...u...I..A..p...p...l..G..l..........................................................................................................................................................sc.....l.hAcl..........................................................................................................hP..cc..K...........hpl.lcp.............L.p.t.....................................................psp.....h..................VAM.......sG..D.Gl..ND...A.PALtpAD..........................................................................................................................	0	2722	5262	7124
+1029	PF04227	Indigoidine_A		Indigoidine synthase A like protein	Kerrison ND, Finn RD	anon	COG2313	Family	Indigoidine is a blue pigment synthesised by Erwinia chrysanthemi implicated in pathogenicity and protection from oxidative stress. IdgA is involved in indigoidine biosynthesis, but its specific function is unknown [1]. The recommended name for this protein is now pseudouridine-5'-phosphate glycosidase.	25.00	25.00	30.30	25.00	20.20	21.30	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.78	0.70	-5.19	90	1192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	1117	6	398	842	476	280.60	54	79.09	CHANGED	sEVppALssu.c.PVVALESTIIoHGMPYPpNl-sAppVEphlRcsGAVPATIAllsGcl+VGLsp--LEtLAp.....s.ps..lhKlSRRDlshslApsts.....GATTVAATMlhAphAGIcVFATGGIGGVHR.....G..A....EpoaDISADLpELu+TsVsVVsAGsKSILDlstTLEhLETpGVPVluY.....to-......chPAFaoRpSGhpsshcl-osp-lAphhcs+hp...LuLpu.GhllANPlPc-ttlstphlsshIppAlt-AcppGI..sGKslTPFLLs+ltElTpGcSLpuNIALVpNNAclAAcIAhsl	.............................EVppAl..p..sp..pPVVALESTIISHGMPaPpNspsAhpVEphlRp...............pGA...lPATIA.II.sGhh...+...lGLspE-lEhLup...............p...cs....VsKVSRR....DLs.hllA.....t.....tp...s.................GATTVAuTMIhA.shA...........GIcVFuTGGIGG..VHR....................G..AEp.....ThD.ISADLpE.LupTs.VsVVCAGAKSILDlshThEYL.............ETh......GVPVlGY.......pTc..........phPAFasRp...S..u.....hclsh..pl-osp-lAchh...ts+hp...h.....s...L.p.G.G.lll.A.NPIPc.paAhsc.phIsssIspAltEA-........pp.Gl..p..GK-sTPFLLu+lsElTsGcSLpu..............NIpLVhNNAhLAucIAht...................................................................................................	0	144	246	340
+1030	PF04613	LpxD		UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD  	Kerrison ND	anon	DOMO:DM04521;	Family	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyses an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein] [1]. Members of this family also contain a hexapeptide repeat (Pfam:PF00132).  This family constitutes the non-repeating region of LPXD proteins.	22.40	22.40	22.70	22.40	22.00	22.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.20	0.72	-4.44	90	2398	2009-01-15 18:05:59	2003-04-07 12:59:11	9	36	2248	13	574	1707	1557	71.20	31	20.84	CHANGED	sshtlpulAsLppAsssploFls.st..KYt.ptLpsopAuAlllstc......tp........stshshLlspsPYluaAplsphh	.............shhlsulAslpp..A..psuploFls..Ns.....KYp.cp.....Ls.p.opAuA.Vllspc.......s.............hs.s.ps.shLll.c.sPYlsaA+luphh.............	0	177	363	480
+1031	PF00244	14-3-3		14-3-3 protein	Finn RD	anon	Prosite	Domain	\N	21.40	21.40	21.40	22.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.50	0.70	-5.28	85	2097	2009-01-15 18:05:59	2003-04-07 12:59:11	15	15	551	104	918	1919	23	196.20	57	83.35	CHANGED	R-chV..ahAKLAEQ.AER.Y....--MlptMKplsph............tsc.LosEERNLLSVAYKNVlGuR.RuoWRll..SSIEQK-..csc...........................ppphphl+pYRpKlEpELsplCs-lLsLLDppLlPs..........u.........s...ssE.S+VFYhKMKGDYYRYlAEas.su........-c+c.csscpuhpAYppAp-lAp...pp..LssTHPIRLGLALNFSVFYYEIhNsPccACpLAKpAFD-AIu-LDs..LsE.-SYKDSTL.IMQLLRDNLTLWTS-tpscp	..................................................................pp.l.hA+LAEQ...A.ER.Y.................--Mst.MctVsp.............s.EL...osE..ERNLLSVAYKNV....lGuR.RuSWRll..SSIEQKpcsp.....................................-pphphh+..........pYRpKlEpELpplCp.s.lL..p.lLDpaLIss...................u.................s.....ssE..SKV....F.YhKM..........KGDYa.RYLAEht.....sG.......................................s.cR...p........ps.s-po.pA..Y..pp.....A.-lAp....sc.....h...PTHPIRLGLALNF.S.V.F.YYEIL..NuP.-+..ACp.LAK.p...A...FD-AIA.ELDo..L...s.E....-...S..Y...K.DS.TL.IMQLLRDNLT.LWTS-.tt..t.............................................................	0	308	472	682
+1032	PF02826	2-Hacid_dh_C	2-Hacid_DH_C; 	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.91	0.71	-5.12	161	20266	2012-10-10 17:06:42	2003-04-07 12:59:11	14	74	4565	208	5776	22821	13988	171.60	30	48.83	CHANGED	luhhLuhsRpl...hphppth....+pG....pW..........t...thhuh....clpG+TlGIlGhGpIGptlAchhp.uFGh.cllsasht.....t...........pthsh.phs.sl-cllppuDhlolpsP.loscTcpllstctlstMKssu.....hlINsuRGsllDcpALlcALcsGpluuAuLDVappE...........Phs....ts........p...sL....hp..hsN.....lllTPHlu	..................................................................................uhhlshhRph.....t...h...t.t.th............c.p.s.....pW............................t......t.hhuh..........cl...p......G.+...T...l.Gll.G.h.G.p.....I...Gp..t..............l.A....p..h.hp...ua..G.h....p.....l...l..h..a..s..h...................hp...............t......................tp..s.......h.......p......h......s.......s.....L.......-......c.....L..............l.....p....p.......u.....D...l...l.o...l...p.s..P....h........s.......s........p...................T.c..............p....l..l.....s...t....p..................t....l.s...t.M...K.s.....s..u...................hll.N...s..u..R...G....s.l.l.D.p.p.AL.l....pAL.....c....s.....G........c....l.t..u....A.u.l.DVa.p.p..E......................................P.hs.......t.s......................p.......s.L................hp.....h.s.N.............l.ll.TPHlu.............................................................................	0	1662	3388	4776
+1033	PF02834	LigT_PEase	2_5_ligase; 2_5_RNA_ligase;	LigT like Phosphoesterase	Bateman A, Mazumder R, Anantharaman V	anon	Bateman A	Family	Members of this family are bacterial and archaeal RNA ligases that are able to ligate tRNA half molecules containing 2',3'-cyclic phosphate and 5' hydroxyl termini to products containing the 2',5' phosphodiester linkage. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family. The structure of a related protein is known [1]. They belong to the 2H phosphoesterase superfamily [2]. They share a common active site, characterised by two conserved histidines, with vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.03	0.72	-4.00	107	1248	2012-10-03 21:31:47	2003-04-07 12:59:11	11	3	1026	8	425	2631	248	80.60	31	52.39	CHANGED	ls..spph.ppltpltpplc....thsh+h....ct.s.HlTLthlt.phs....pppls...plhpthtph..t...h.lplpthuhass...tspsla	.....................................tlPsphppplhp.hp..ssh.h............s.....tu..s...+.V......tspNhHlTLu.FLG.-ls...........scc.c..........sltp.h.....h..u...c.....l................c...p..ss..F..s...l.pLc.shGtah....csRVlW............................................	0	167	289	360
+1034	PF03475	3-alpha		3-alpha domain	Aravind L, Anantharaman V	anon	Aravind L, Anantharaman V	Domain	This small triple helical domain has been predicted to assume a topology similar to helix-turn-helix domains. These domains are found at the C-terminus of proteins related to Swiss:P32157.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.87	0.72	-4.24	49	1443	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	1316	6	193	768	20	46.50	31	19.76	CHANGED	cloVtchhplhascphs..hptlccllsh.ssLutoW+pphp+Rlpptps	.................cloVpcssp.lhap......hs......p-tlccl...Lss.ssL.SsoWpcphpKRhtpt..........	0	52	97	146
+1035	PF01612	DNA_pol_A_exo1	3_5_exonuclease; 3_5_exonuc;	3'-5' exonuclease	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_659 (release 4.1)	Domain	This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D).  Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction [4,5].  The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein [3]. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.15	0.71	-4.79	27	6914	2012-10-03 01:22:09	2003-04-07 12:59:11	15	92	3529	32	2350	6043	5677	173.20	23	27.78	CHANGED	hphlpsppthpchhppltstt......slAlDTEppshph..h.p.hstllQlpst.....ptsalhsshthts..........hphLptllpssphhKlhasschDhthltp........aulhhpsla-s..lAstllshtpt..........auLssLspphls...hthspppttucap.....tcslhcpth........tYAutDshhhlp..lhppLpp.lp	.................................................................................................................l.s.tth.tt.hh.t.t.l..pt.ts............hlAlD...T.....E....t...........s.......s.............h.....p..s........................h....p.............h....h....h.......hl.pltss...................pss.h.l.......s..s....h..s..h...t.s..................................................hp..Lp..s.lL..p..s...s.s..l.h.....K......lh..as.h.c......D.hth.ltp............................................h.G..l...t...h..p.....s.....l...h...........Ds...........l...t...u...h..l..h..s.h..stt....................................................huh.s.....s...L..s...p..c.....h.ls.........hs...l.............s...h..p....p......t.....u..cht...............................tcsh...c.pth..............................pY.AAt..Ds.hhhp...lhptlh.pl.............................................................................................	0	797	1441	1966
+1036	PF00803	3A		3A/RNA2 movement protein family	Bateman A	anon	Pfam-B_1054 (release 2.1) & Pfam-B_6332 (release 7.5)	Family	This family includes movement proteins from various viruses. The 3A protein is found in bromoviruses and Cucumoviruses. The genome of these viruses contain 3 RNA segments.  The third segment (RNA 3) contains two proteins, the coat protein and the 3A protein. The function of the 3A protein is uncertain but has been shown to be involved in cell-to- cell movement of the virus [1]. The family also includes movement proteins from Dianthoviruses.	25.00	25.00	35.30	33.40	22.10	17.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.29	0.70	-5.30	27	894	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	89	0	0	507	0	209.50	48	84.13	CHANGED	sppstusspppLlptlhu.ps.hpthtpcsshuphp.hpussphshh......sLlPssstsplsshhp......opacssphsosG...................hhpls+lllhlsPTls.sssGpVpltLhDsshss....hpslst.pphplphsss...PtlhsFhssYshPhpp.s...........pRCFtlshphsuhh..spusSshSlhhhWptphsspspsYp.pssthh.lp..hpRt.thpshsthpp...alcush...spssstthlhspshsh	....................s..plutcsuss.lsp.aSsss.chsl.spthDsu+t+hhhsspusSsh...........SlsEucuaDl.ARhlV-pspHlSNWKNDhhVGNGpppsshsIpIhPTWsSp+pYMhISRlVIWVsPTIP.sssGcLsVuLlDPNhPo.........-.cpVIL+sQGol.hDPhCFlFYLNWSIPKhsNTP............csChQL..pLhCs..pcY...thssohuSlh..WptpFsspsts.pp.ss.........................................................................	0	0	0	0
+1037	PF02829	3H		3H domain	Bateman A	anon	[1]	Family	This domain is predicted to be a small molecule binding domain, based on its occurrence with other domains [1]. The domain is named after its three conserved histidine residues.	25.00	25.00	30.00	44.50	21.30	19.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.17	0.72	-3.97	57	945	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	913	1	147	544	7	98.00	42	55.62	CHANGED	lssp..H.ss-chc-ELphIVc.pGGplhDVhl-HP.lYG.clpupl.tlpscp-VppFlcplpps.cup.....LppLTs.GlHhHTlpAssccsl-pIpctLcctGaLl	...............htsp.H..psEchcpELphI.VD.pGGpVp.sVhl-HPlYG..-lpu.L.plpsRcDVpcFlcplpps.pup......LSpLTc.G.lHhHplcA-oppsLctIccALcctGaLl...................	0	62	104	124
+1038	PF00725	3HCDH		3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_743 (release 2.1)	Domain	This family also includes lambda crystallin. Some proteins include two copies of this domain.	21.00	21.00	21.00	21.00	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.19	0.72	-3.59	77	10901	2012-10-02 19:36:46	2003-04-07 12:59:11	17	35	3006	55	3264	9099	4385	93.80	27	23.85	CHANGED	GFlsNRllhshhsEAhpllpcG.Assc-lDpshchthGaP.MGPhpLsDhlGlDsshplhp.......hhtpths-p...thp.s.lhcphscsGchGcKoGcGFYpY	.............................................GFlsNRl.l.h..s.h.l.s.EA.h.p.h.l.p...........-......G.......h..u.s...s.p.c......l......Dtsh.p.hs..h...Ga...P...h...G...Php..h.h...D...hl...G...l.Dsshp.l.hp...........................hhtpt.hspp............hp..s..s.....hl.pph.h....p.t.sh.h...GpKs.s..t..Gaa..............................................................	0	922	1912	2683
+1039	PF02737	3HCDH_N		3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_743 (release 2.1)	Domain	This family also includes lambda crystallin.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.95	0.71	-4.63	74	8383	2012-10-10 17:06:42	2003-04-07 12:59:11	13	46	3107	48	2683	14660	8387	177.00	33	34.30	CHANGED	pVuVlGA.GsMGsGIAtlhAps.GhpVslhDh......spptlpcuhptlpp...thtphhpcGphs........ttphsthhsplp..hsschsshs.su.DlVlEAVsEslclKpclFtcl-tls.tscsIlAoNTSulsloclupshp.cPc+..hlGhHFF.N.Ps.lM.LVElltutpTuscslspshshscpl.GKtPVhV.pDs	....................................luVl..G.u.G.h..M........GuG..I.......A..h.......h..h........A....t..........t.....G....h..s......Vh.lhDh.................st...p...s....l...s.......p...u........h...s...t...l.tp...........L.p..c..t....l..p..+...u...+..ls.................................t.t.p.hs..t..h..l..u....p..l.s..........s.......s...s.......c..........h.....s....s......h......s......c......s..........D.......l.V...............I........E.........A......V........s......E......s.......h......c...l.K......p...pla.t..c..l-.p..h.s.....t..........s.c......s..l..lASN.TSolsIs.pl..A.............s....s.......s.............p.......+........P.......cc..............hlGhHF..F..N...Ps...hM.LVEl.lt.........ut......p.Tusps.l.s.......pshsh.s.p.p.h..GKsslhl.pD.........................................................................................................................	0	802	1633	2233
+1040	PF02446	Glyco_hydro_77	4A_glucanotrans; 4a_glucanotrans; 	4-alpha-glucanotransferase	Bateman A	anon	Pfam-B_1924 (release 5.4)	Family	These enzymes EC:2.4.1.25 transfer a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan [1].	25.00	25.00	26.80	25.60	23.20	24.80	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.45	0.70	-5.93	14	3053	2012-10-03 05:44:19	2003-04-07 12:59:11	12	17	2557	11	694	2467	761	483.60	30	78.89	CHANGED	lplhSL.oc...GIG-hGppAh.hlDahpcsG...hplhQlLPlssou.ssu.......PYsShSuhAhNslalclpsLs-tthlc............hpchpphpstspVcYsplhthKhshL+csacthpppt...pppsFppFtccp...phWLcsaAhF..hAlK-phss......hsWspW.....pshptpctpslpchpcphp-clpFataLQalhapQhppl+saApp..psltIhGDlPIhluccSuDVWs..chFphs.......tsuGsPPDhFsppGQtWu.PlYsactLpccsapWWhcRlctshphasllRIDHhhGFhphW.lPt.................ucppAtsGcahhsPG...................................................................cclhshlhpths................................................................ph.lIuEDLGslss-VcthhcphulsGh+llpFshs.-spsshlPpsh...ptpsVshsuTHDssTltuWacst.....................pccpphhtpaLs......ph.pcthptsll+hshposuhhtIh.hpD....hLuLss-........tRhNhPuTssp..NWsaRlpss.......-.hssppphhphltplh	....................................................................................................................hplhoL.op...t.....G.I.GD.Fup.th..hl-.h.ht.c.sG.....htl..lhslhss.s..t.su..........................P.Yp.s...SthhhNshaIc.l..p..t....l...-.h..t.hhptt................................t....p..t.....h.....p.....t..h.....p.....s.....s...p......h.lD.Ys.tl..hthKh.s.hL..c.hsa.pta...........t....p....p..........s.............p...........t........s........F...ppF..ht..pp....................tth..Lts.aAha.............sl.+.....c..p.htt.............................h..s..W.....t.Ws........p.......th.......pp....hc.............s............s....sl.....pph......p.p..p..h.........t.-.clpaahalQahhhpQhtth..pp..hApp..hsItlhsDlslhVutsuu-sWsp.c.haths....................................sssG.sPP......D.ha.......u.s.tGQpWG..Psa..s.c....h....hp...t..pu.............Yp.alchl.Rtshphhs...........s..........lRIDHhhGhhchWh.IPt...............................up..s.AtpGt.a.lphPs.............................................................................................................................................................................pclhsh.lthE..t.........................................................................................................................p.h.lIuEDLGs..l..s..sp....lhthhcptGl.uh+lL..Ft..h........................p.......p......p.........s...........h......h....h....P..p.ta.............stpulshsuTHD.sTl...tG.aapst..c.................................................................................pp..ppph..h......t.t......h...l..s............................t..h.............t....p.......s.....h....t....p....s..h...l.....p...s.h...h....s....o......h.....sp.h..h...h.h...h..tD......................lLulp.p.........................t.hNhPGTsst...NWph+hsts.......p.h.t.tth........t....................................................................................................................................................................................	0	231	453	586
+1041	PF01812	5-FTHF_cyc-lig		5-formyltetrahydrofolate cyclo-ligase family	Bashton M, Bateman A	anon	Pfam-B_1555 (release 4.2)	Family	5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase EC:6.3.3.2 catalyses the interchange of 5-formyltetrahydrofolate  (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+ [1]. 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin [2].	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.10	0.71	-4.52	24	4810	2012-10-04 00:26:15	2003-04-07 12:59:11	15	19	4472	16	1259	3577	1998	177.40	26	87.98	CHANGED	KppLRcphht.thctlspcphtptsptltp+lhshhthppu.ppl........uhYlsh.ssEhshp..tlhpphhptschlhhPhhp.ps..................................s.h.ps.ht........lhpPhpthth..s..........plDllllPulAFD.ppGhRLGhGtGaYDRhLuphpt.....p.htlulshcpQhhs..plPt-....aDhslchllss	...................................................................................KpplRpthhp..phps....l.....s.....p.....p..p...p...p....t.....s..p.....t....l.t.p...p....l....h...s....h...........t...h.......t....p....A.....p......s...l.........................................................uhals.h..s..s..El...s...Tp...........sl..l..c..p...h..h........p...........p........G.........K.....p.....l..h..l.Phh.ps.ts..................................................................................h...h...h...t...h.p..s....t.s....t...l....h.p.s..t.a.s................................lhEP.t.ts.h.t.h...................................plD.llllPslA.....F....D...c.......p...G...h.....RlGhGGGaY..D....RhL..s..phpt..........................hs.........l....u.ls.a...s..t..........Qhl........c........p..........l....P....s...Es.........a.Dl..slstllT.....................................................	1	390	782	1045
+1042	PF02739	5_3_exonuc_N		5'-3' exonuclease, N-terminal resolvase-like domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_716 (release 3.0)	Domain	\N	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.04	0.71	-4.88	25	6210	2012-10-03 20:43:45	2003-04-07 12:59:11	11	20	4577	17	1278	4680	3819	164.00	35	23.04	CHANGED	ppLlLlDGpulsaRAaFAhs......LpsspG.sTs.AlaGFhphLhpllccppPsalllsFDutsp..TFRcchYtcYKusR............spsP--LhsQlshl+EllctlGIshlEhsGaEADDlIGTLAcpAppc..GhcVhIlouD+DllQLls-...pVtlhps........tchphhss-pVhEK.a	...................................................................................LlLlDGpuhhaRAaaAhs...................h..p..s.s..p.G.........T.....s......Alh.G........h........hp....hLt....p...l...l.....p.....c.........................p.......P.....o.........H....hs.........VsF.D.....................s.t................t...............p......TFR..............p-h.as.cYKusR........................................s.s.hP..-....-........L......p......t......Q....h......s....h..........l.......+........ch..l....c....u......h........G....l..........s.h......h.p.h.....s.GhEADDlIGTL.Ap..p..u...p...p.p.......G.....h.......p.V.h.I.loGDKDhhQLlsc......p....l.t..lh.pp...........hp...phh.s.ptlhc+.....................................	0	413	828	1081
+1043	PF01367	5_3_exonuc	5_3_exonuclease; 	5'-3' exonuclease, C-terminal SAM fold	Bateman A, Griffiths-Jones SR	anon	Pfam-B_716 (release 3.0)	Domain	\N	40.00	40.00	40.30	40.00	38.60	39.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.20	0.72	-3.78	27	6018	2012-10-01 19:52:02	2003-04-07 12:59:11	15	19	4488	11	1254	4486	2458	100.70	36	13.83	CHANGED	lsPpQ....hhDhtALhGDsSDNIPGVtGIG-KTAhpLLpcaGSl-slhp..Nl-plps.ph+......ctLpspc-sshhScpLuslcsDlslplsh-sh.......thps.stpplhp	.........lsPpQ....llDhhuLhGDoSDNlPG....V....sGl....GpKTAhpLLppa.G.ol-slhp.....pl..-....p....lp...s.......+.h+...........................cpL..p..p..s..p..-.............t..AhL..S+..pLAo.lps.Dl...s...l...s..h...s.h...cpl.......thp..t......t..................................................	0	404	813	1059
+1044	PF03491	5HT_transporter		Serotonin (5-HT) neurotransmitter transporter, N-terminus	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.30	20.30	20.90	22.20	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.17	0.72	-3.84	3	54	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	34	0	20	41	0	39.10	70	7.22	CHANGED	ENGVLQKuVPTPADKVESGQISNGYSAVPSTGAGDDAcHSlP	.............ENGVL..QKsVPsPGDKsESGQISNGYS....AV....PSPGAGDDspHSIP.............	0	1	2	4
+1045	PF02096	60KD_IMP		60Kd inner membrane protein	Mian N, Bateman A	anon	IPR001708	Family	\N	25.40	25.40	25.50	25.50	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.46	0.71	-4.65	147	6198	2012-10-01 21:53:17	2003-04-07 12:59:11	15	26	4682	0	1609	4484	3134	199.40	31	48.09	CHANGED	s.saG..luIIllTlll+.lllhPLshpph+Sh....t+Mpp....lp..Pclp....clpc..+a...............ps.ctpc.....hppEhhcLYccpslNPh...uGCL.PhLlQhPlhhuLatslpp...............................................................hp.....l...........pp.............ssFh.........................W......lpcL...........ussD............................................hhlLPllhulshhlpppl........s....................pst......pt+hhhh...hh.Plhhh.....hhhhphP..uGLsLYWhssslhslhQphhl.pphht	............................................................................................................................................saGhuIIl.lTl.ll..R...hll.h.P..L....sh.tp....hpoh..................tK.M.pt......l..p......Pclp.................tlp.c+a...........................................t-..-pp+...................hp..p....E...h...hp...LYK......c..p......s.l..N..Ph......uG..C....L.....PlL.l..Qh..Pl...ah.ALY.hslhp............................................................................................................................................shp...............l.............pp..................usFh.................................W.............l..cL............ussD.......................................................................................s.hh.lLPl.lh..uls.h.alpp.t.l......................................s..................................s.ps..htphhhh.................hh.Pl..hhh.....hhh.....h........hP....................uGLsLYWlluN.......lhsllQphllpp...t............................................................................................	1	548	1016	1354
+1046	PF00428	Ribosomal_60s	60s_ribosomal;	60s Acidic ribosomal protein	Finn RD	anon	Pfam-B_151 (release 1.0)	Family	This family includes archaebacterial L12, eukaryotic P0, P1 and P2.	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.32	0.72	-3.59	107	2118	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	646	27	1183	2032	138	88.10	32	53.35	CHANGED	psossslppllpuush.plcshthphhhptlp..uc.slc-llsssttt.....................uuuuusAAuuuuuuuusAspcpccEEcc...........EpD-..DMG.hu...LF	......................................................................sotsslppll.......puush.pl-s.hthp..h..h.......hptlp..uc.slc-llsssssths............................................uuuuAs.Au.u...u...u...u.u.u...u.A......s.s.sp...E.cccEEcc...........E..EoD-......DM..G..FG...LF.......................	0	390	647	956
+1047	PF01591	6PF2K		6-phosphofructo-2-kinase	Bateman A	anon	Pfam-B_717 (release 4.1)	Domain	This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis [1]. This enzyme contains a P-loop motif.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.39	0.70	-5.28	11	1160	2012-10-05 12:31:08	2003-04-07 12:59:11	13	22	311	13	696	1195	96	194.90	37	39.97	CHANGED	tcsssssp.pss.hhIVMVGLPARGKTaISpKLTRYLs....WlGhsTKVFNVGpYRRpssps........pshcFFcs-NpEuhclRcpsAhsALcDlhsaLscEsGpVAlFDATNTTRERRchIhphsccps........hKshFlESlCsD.plItpNIpplphuSPDYtspss-c.AhcDFh+RIcsYctsYEPLD.-ppDcsLSaIKlls.lGpphllNpVpsalpSRlVYYLMNlHlpP	...................t........pss.hhllMV.GLPARG......Koal......u..pK...LsR..YLs.................WlG..h.o.+..l.....FN..lG.p..Y.R.R.pts.tt..............................................ps..h...p...F.F.p.ss..Nt..c.uh...p.lR...cphAhtslc..........Dlhp...al............p....p............p............s.....G..........p...........lu..l.................a......DATNoT.+cRRphlhp.h.h.p.p..p.s........................................h..c..shFlESlCsD....pllttNI.h.ph.p.h.s.s.........PD....................Yhs......h.s...cp...AhpDFhpRIppYct.....s.....Ypsl...s..................-.....p.....p..l.............s.....aIKhhs...sGpp.h.hl.s.p.l.p..salpo+lVaYLhNl+lp........................................................................	0	187	351	557
+1048	PF00393	6PGD		6-phosphogluconate dehydrogenase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase.\	\	 The domain contains two structural repeats of 5 helices each.	20.40	20.40	20.80	20.60	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.91	0.70	-5.20	58	5458	2012-10-02 19:36:47	2003-04-07 12:59:11	14	19	3935	36	1173	4118	977	231.40	44	59.81	CHANGED	GHaVKMVHNGIEYGDMQLIuEAYplLKpsLGLoscEluclFpcWN.pG-LcSYLIEITucILpt+D.....ps.G..p......sLVDhILDpAGQKGTG+WTs.sAL-lGlPlshIsEAVhARhLSuhKcERltAS+.hLsG...sp.....sthss-+ppal-sl+pALYsSKIsSYAQGFtllptASc-asWsLshupIApIWRGGCIIRutF.LscIpcAappsssLsNLLlssaFpptlpptpsuaRclVu.hAsptGlPlPuhSoALuYaDuYRsspLP.ANLlQAQRDaFGAHTYcRh..........D+pGs..FHTpWs	................................GHaVKMVHNGI.EYGDMQLIuE..uYplh..+..p..s....h..s..h......s.....sc.......-.......huphFpcWN...pG.-....L.s.S.aLl-IT...tclh.ptcD.......pp..u..p.....................ll.-h.I......h.....D.....p.....A.....u......p.....KGTGKWTs.sAL-lGhPlslIs.EuVFARhlSu.h.K.p.p.Rht..A.sp..h.h.t.....s................scctthl.cpl+pALahuKlhuYAQGF..hptAu.pp...tWs.lshuplA.laR.sGCIIRu.......F.Ltp.I.pp.Aa.tp....s....s....t.l.................s.Llhs.hFtth..h..tp.h........tuhR.....plls.h............u............hp.G...........lP...........hPshu.uu.l.s.a.aD.uhp.st.L.P..AsLlQ.......AQRDaFGuHsaphh.........s....t.........hH...W...............................................................	0	355	715	977
+1049	PF02495	7kD_coat		7kD viral coat protein	Mian N, Bateman A	anon	Pfam-B_2886 (release 5.4)	Family	This family consists of a 7kD coat protein from carlavirus  and potexvirus [1].	21.10	21.10	21.40	23.50	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.89	0.72	-4.52	61	349	2009-09-10 16:31:06	2003-04-07 12:59:11	12	1	114	0	1	324	0	58.80	27	70.57	CHANGED	h....hhhhlullssllslhhl.....psssssChllITGESlplpu..C..hsschlchl.psL+shst	.......h..lhhhlslls.sllslhhl........ssppspCpllIoGculhIss..C.t.os-hlchl..shpPhp.s........	0	1	1	1
+1050	PF02294	7kD_DNA_binding		7kD DNA-binding domain	Mian N, Bateman A	anon	Pfam-B_8148 (release 5.2)	Domain	This family contains members of the hyper-thermophilic archaebacterium  7kD DNA-binding/endoribonuclease P2 family. There are five 7kD DNA-binding proteins, 7a-7e, found as monomers in the cell. Protein 7e shows the  tightest DNA-binding ability.	25.00	25.00	119.50	119.30	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.11	0.72	-4.29	2	33	2012-10-02 16:56:36	2003-04-07 12:59:11	13	1	18	30	10	32	0	61.50	90	96.62	CHANGED	ApV+FKYKGEEKpVDhSKIKKVWRVGKMlSFTYD-.sGKTGRGAVSEKDAPKELhpMLt+tc	s.TVKFKYKGEEKEVDhSKIKKVWRVGKMISFTYDEGGGKTGRGAVSEKDAPKELLQMLEKQK.	0	2	2	9
+1051	PF00001	7tm_1		7 transmembrane receptor (rhodopsin family)	Sonnhammer ELL	anon	Prosite	Family	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.81	0.70	-5.25	64	42866	2012-10-03 04:04:29	2003-04-07 12:59:11	16	290	7772	141	17156	63287	11	225.60	18	72.53	CHANGED	GNslVlhslhtp+ch+....sssshalhsLAluDLlhslsls.hshhhhhh.........pWshGp...hhCclhshhhhhshhuSlhhLsslolDRYlAIscPhphtthps...tpuhhhhhhlWlhuhllulP.hhhhttpt.pps.............hhChhphsp.............hhlhhtlhsFhl.PlhlhhhsYhhIhppltpptt.................................................................................................................................................ppcp+ss+hlhsllslFhlCWhPatlhhhltshpphs............hthhh.lshhluhsssslNPllY	...................................................................................................................................................................................................................................................................................................................Nh.h.s..l....h....h.......h...h...t........p.....p......p..h+...................ss......h...p...h....h...l......h...s.....L....A.h.....u..D.....h.......h......h...............s...h............h.....h..................h........h.....h........h........hh................................a.........h......u.............h.h...C......p.....h.........h.......h..............h.......h............h.......h........h........................h...........h.......s......o.....l..........h......................l..s.h..l....u......h......-................R.............a...............h.........s................l......s......p.......s................h........p..........h................h.........t.............h.....h..............p...........................p..............t...............s.......h......h.......h......h.......h......h........h........W..............h......h.........u......h.........h..........h......s......h......s.........h........h.........h.....................h...........t...............................................C.h........h.................................................hh.h..h..h...h...h.....h.....h.....a.....h.....l.......P.....h......h....l.......h......h......h......s.....Y...h...h...l...h...h...t....l...t.....p...t..t...t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..t...c....t....c......h...h....p....h........h....h............h....h....l...............h....h.......a....h...l....s........a....h...P.....h....h.....h......h........h.....h...........h.h..........................................................h..h......h.........h....h....h...h........s...s...hhsPhlY............................................................................................................................................................................................................................................................................................................................................................................................	0	5181	6677	11247
+1052	PF00002	7tm_2		7 transmembrane receptor (Secretin family)	Sonnhammer ELL	anon	Prosite	Family	This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognised. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97 (Swiss:P48960); calcium-independent receptors for latrotoxin (such as Swiss:O94910), and brain-specific angiogenesis inhibitors (such as Swiss:O14514) amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins (e.g. Swiss:P83119). Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.78	0.70	-5.29	31	4718	2012-10-03 04:04:29	2003-04-07 12:59:11	19	348	246	3	2544	4248	5	225.10	22	28.73	CHANGED	hhslpllhhlGaulS.LsuLhlAlhlhshF.RpL+CsR.NhIHhNLhhoalLpshshhlt.tthlhspht....p...................................h....C+lssshhpYhhhsNFhWhLlEGlYLasLlshs.....ahs-.+thhhhahllGWGhPslhlssWshs+...............hhats............spC.Whsp..ptshh....WlhpGPlhhslllNhllFlpllplLhpKlp......ssphucpcptph.................................hs+ooLlLlPLLGlpall..hhhhsss......phlhhahphhlsSF....QGFhV	.......................................................................h..hthl.hlG.h.sl...S...lh...s....Lh...h..sl.h...h......h......h......h..............h.......+................p...............l.................p............s.....p.....c......s......h.....l....p........h....s.L....h.....h.......u.......h....h..l.......t....t..h....h..h......l...lt........h....h..tt......................................................................................................................C.p...hhs.hh.h.aa.h.h.....lu.s..ah.....W..h...h..l..Eu...l..h.L...a.....h.....h...l.shs...................h..s.p....p.....t.h.h..h.....h.....a....h....h..l.....G.........W....G.............h..Ph.l..lls..l...h.sshp.......................tha..t..s.......................................p..t.....C....W..hp........pt...h..hh.............a....h...h...h..u.P...h...h....h..h.l.h...........l.N....h.l..h...h.l.h..h.....l.h..h..l....h...p.php..........tt.p.h.t...p.t.p.p.hh..............................................................................hhh.s.s..hh....L..h.....L...h..G.....l.....pahh..........h.h.....h....h.......tp..........t...hh....hh.hh.hh...hsuh....Q..Ghhl..............................................................................................................................	0	852	1057	1672
+1054	PF02949	7tm_6		7tm Odorant receptor	Bateman A	anon	Pfam-B_436 (release 6.4)	Family	This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-11.67	0.70	-5.57	36	3836	2012-10-01 21:54:26	2003-04-07 12:59:11	15	33	114	0	2186	4221	0	248.70	14	75.32	CHANGED	shsphhpslphhssshsshhKhhhhhhpppchtclh......ptLppl.tcsh.ppp-phhhtphhp...ptp....hlhhhhhhshshhshhsh.....lshlhttpt..............sh.hhh.......h.hsap.....sph.aah.thhhphhshshsshttlssDshhhhhhhhlshphclLpt+lcpltts................................................................................ptsppp.....ppLtpslppHppll..................chsptlpshhshshhspFhssuhllshshhplhhhss...shphlhh...lhahhshhhQlFhhCahuspltppupplspAla.pss.Whs......tshch++hllhhht+sQ..+shplpAss.hhslsLssahslhphua	.....................................................................................................................h..........................p.h....hh................h......h................t...h.............................................................................hh................hhhh......h.h...h..h..h...h...h....h.h.......h..h.h.h...................h....h..h...............................h.....h..h................................h...h...............t........hhh....hhhh.p.h.h...h.h.....h...hshh.......h...........sh.s...s.h........hh.h...h...h.....h....h.t...h..p...hph..l..t....p.l.pp.h.t..........................................................................................t..t..................ttl...h.t....h...lphHttlh................................................................ph.hp..h....p....t..h.h.t....h....h..hp.h.h...h....h..h.h.l...s..hh...h.............h...h..h...h........................h...h....h...................h...h..h...h...h...h...h....h...h...p.h..h....h.hsh..h...up....l.................t............st....pl.hts..h........a...p........W....h.t..............hs......p.....pp.......lh.hh.h.psp....p..sh...hpsh..hh....h..s..h..hhth.........................................................	0	582	712	1980
+1055	PF00207	A2M		Alpha-2-macroglobulin family	Finn RD, Sammut SJ	anon	Prosite	Family	This family includes the C-terminal region of the alpha-2-macroglobulin family.	20.40	20.40	20.40	20.40	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.07	0.72	-4.41	131	2819	2012-10-03 02:52:13	2003-04-07 12:59:11	17	148	1230	58	881	2534	98	88.80	26	5.98	CHANGED	oWlWpsh.ls........t.s...GptslshplPDoIT.oWphpAhulosst.........................GlGlups...plpsh+sFFlslpLPYSlhRGEplplpssla.NY.hsps..lp.lpVpl	............................................hha...hhs.............tp....Gpspl.shh........lPDo...lT...pWc.lh.A.....h.u.h.s.s.s.......................................................s.hGhscs........plpshp...shhlphshPh..ltpG-p.hplthslh.Nh...h.sp.s...p.hpl............................................	0	218	372	622
+1056	PF01835	A2M_N		MG2 domain	Bateman A	anon	Pubmed:16177781	Domain	This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin [1].	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.41	0.72	-3.75	175	2926	2012-10-03 16:25:20	2003-04-07 12:59:11	14	140	1451	60	921	2616	150	95.90	22	6.25	CHANGED	psalhTDRslY+PGcsVph+sl..shs.................t............slp...lplhcP.sGppl.pphhh............Ghhphs.aslspss.hGpaplpsph.........................tstthsstpFpV	..............p.halhTD+slY+PG-s.V.phpsl..hhchc.....................................hpsh.ss....pslp...lp.l.....h.cP...sGp.h.l.pph.s....................t..pp...Ghh..phs..at..L..sps..s....s..tG....taplpsph...............................t.sphhphpFpV............................................	0	235	407	669
+1057	PF01356	A_amylase_inhib		Alpha amylase inhibitor	Bateman A	anon	SCOP	Domain	\N	25.00	25.00	25.00	58.00	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.41	0.72	-4.18	6	15	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	13	7	1	19	0	65.90	51	70.74	CHANGED	upPAPACVchapSWRYTpVsNsCupsVSVTVsYpDGspuPCtslsPGslsTFu.GYGTpuNaVpulshC	.t.pPAPACVchapSWRYTsVsNsCussVoVTVsYpDGppuPCRslsPGshsTFu.GYGTpGNashulthC	0	0	1	1
+1058	PF02137	A_deamin		Adenosine-deaminase (editase) domain	Mian N, Bateman A, Iyer LM, Zhang D, Aravind L	anon	IPR002466	Family	Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc [2].	19.80	19.80	21.20	19.90	18.90	18.60	hmmbuild  -o /dev/null --hand HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.43	0.70	-5.12	59	781	2012-10-02 00:10:39	2003-04-07 12:59:11	13	25	275	2	446	770	16	308.00	27	55.17	CHANGED	oluTGsKslss..pphuppGph....lpDsHAEllARRuhhRaLhpplthhhpt......t.tpsl....a..............h.p..tssth........acL+sslphaLYlSpsP.CGDAsl...tp.............................................................................................................................................sstthlsscsss....tsh.shpGll.htsspu...-phhoh..SCSDKls+...........WsllGlQGuLLuphl..cPlYlsolllu..t.........hpts......phpRAht..pRh.....................tth.tsaphpp.Phht.......t.......................................................................tspsppptpsss.............................hSlsWsh...............sshplplsss....ppGp.........sshtstSclsKtshaptatpl......ht............ppphts............sYt-hKpts...ppYppsKpplhpt......................tshssW.lpKs.-	...........................................................uluTGs+Clst.......phh.s....pG......h..............lpDsHAEllARRuh...h.R.aL....hpplthhh...st................ppol..a...........................................................t.....t..t..s..............................................................apL+.pslphahYh.S..psP.C...GDAphhs.hp...............................................................................................................................................................................................................................................ssttslss.p.s.s...s..............sh..ph.Gll.............p.u.....-.....p..hhoh..SC..SDKls+...........WsV...lGl...QG...uLL..ophl...pP.......lYlpol..llG........................hptt.......................................thpRA..h..h....pRh...........................................t.htth...athpp...shht...............................................................................................................tsptpt.hpsss.............................hS.ls.Wsh...................................ss.pl.pl..hss..ppGp............................tshtt.SplsKtthhthahp.l..................ht.h.....................ttth.t................................sYt...phKths..............ttYpt.s..pp.hhp........................shssW.htps..........................................................................................................................................	1	123	188	317
+1059	PF00324	AA_permease	aa_permeases; 	Amino acid permease	Finn RD, Bateman A	anon	Prosite	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	478	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.47	0.70	-6.16	26	17705	2012-10-03 01:44:59	2003-04-07 12:59:11	16	47	2920	0	4452	25995	1856	417.10	27	85.04	CHANGED	clhhhuluuslG..sGLalusuhsltpuGssus..llua.llsuhhhhhhhhuluEhushhP.....puGuahsaus+hlus.phGhssGhh......ahh.hhhslsh-lsssshhlpaW...hscls.hhsh..................sslhhsllhhlshhul+hauchEah..hshlKllsllsFlIlu...hhhhtsstssps.............t.hhtsus.....hsss.........htshhushshshFuas.GhEhluhsAuEscsPpKslP+uhppslhplslhYl....................huhhhlshhlshsssshhst...s...........................ushshhhphtslsshssllshslLsusLSuusuulasuoRhlhuLuccshhP.....phhpths+pusPhtulhlohhhuhlsh........lhsthsss..hlhsahlshsulsshhsahhhhhshh..taRpshthpstthstlshchhhhshhshhslhhlhhlhlhhshhhh......hs.......hssts.htsalshhlhllhhhshthhh+phhsphhh	................................................................................................................................HlphIA..lG.G...s..I.......G...sG.L....F....l......G..u..u...t.........s.........l...p..............A......G................P...us............llu.Y..hl.s...G...h.........h............h......a......h...l..M...p.u.L..G............E..h..s......h.....t.P............ssG........S........F......s................s....a.......A................p......c......h..............l...........u......s......h..............h....G..........a....h..s.G.Ws.................................Y.a.h....t....a............h......l.....s.........s....h.........s........-....l......s....A......s.......u.....h.......h...h.......p......a.....W.............h.....P....s....l....P......t.W.l..h..................................................................s.h.h.h..l...h...l....l....h.....s....l....N.........l....h....u....V....+...h....a...G....E....h........E.....F..W........F...u...h....l....K...V....l....s....I..l....s.....h...I.lhG............h...h..h.h...h.s.s..tssst......................................................ht.h..h.p..p..Gu....................................h....s.....s..G.......................................................................h......h......u....h......h....h....s....h.....h...h...s....h..F........u....a.........t......G.....h....E...l..l............u.........l....s....A..........u.E....s..c...............s.........P....p......+................s...........lP...+..A...........l...p...p...l...h...h...R....I....h...l.....F..Y.l.........................................h..u...l....h...l...........l.......h...h...l..h........P....a....s....p...h....s....h....t..s................................................................................................S..P..F..l...h...h....h....p....t.......h.......G.............l...........s.....h....s.......u......s......l........h.....N....h....V.....l.......L....o.....u....s....l.........S..........u....s....N.....S.........u....l....a.....u.......s....u....R...h...L....a.u.L..u....p...p....G.........A..P...............................ph..h...s.....+..h.....s.....+.................p.........u....l..........P.....h.....h.....u.....l....l....h.....o........s....h..h....s..h...l.u.h..........................................................................l...h..s.h.h.sst...........ps..a..h...h.....l....h....s.......h...u....s..........h.....s.......h...l....h.....s......W...........h.......h..........I...h...l...u..p.h..............p.a...............R............+.............t...................................................p......s.............t..................h.........t.................p....h..................a........+.........h...............h.......h........s..........h.......s..........s..........h.................h.......s.......l.......h.........h......h...h.....h...l........l...l......h...h......h...h..t.............................................ht...........................................................................h............h....h...........h..h...h..h...h..h.......h....................hh......................................................................................................................................................	0	1009	2148	3513
+1060	PF03306	AAL_decarboxy		Alpha-acetolactate decarboxylase	Mifsud W, Sammut SJ	anon	Pfam-B_3661 (release 6.5)	Family	\N	25.00	25.00	25.70	25.60	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.12	0.70	-5.30	71	1480	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1246	4	233	763	52	214.90	42	90.92	CHANGED	laQhSTluALhsGlY-Gsholu-LLcHGDaGlGTFspLDGEhIhlDGpsYQhcuDG...s.sp.ls.ssp.psPFAslThFpsc.hphphtpshshpplpphlpphhs.upNlFhAl+lcGpFppl+sRoVsp.QpcPYsshs-sscp.QshaphpslpGTllGFaoPpahp.GlsVsGaHlHFlo-D+phGGHlLDapl.psuplplshhsphplcLP.pstsF....hpuclshps	..........................LaQauTLuuLhuGLhcGTholsELL.cHGD.h.GlGThsulDGE.lIhL.DGcsY..p..sp..u..cG...p.hh.c.l....p....s.-............p...hsPaAslT.Fps-...hpa...p..................p..p.p.h.o.pcplpt....pIcph....h.....uc....NL....FtAlKI.pGpFp+..h+lRhhPp...QptP.Ys.phh-succ..QPEaptps.lpGolVGF.aTP-hac.Gl..us..AG..aHlHFlsD....D+saGGHVhDFtl...ccshl-..ltshsphc.+hPhpspsFhpAclshcs................................	0	52	122	182
+1061	PF04611	AalphaY_MDB		Mating type protein A alpha Y mating type dependent binding region 	Kerrison ND	anon	DOMO:DM04516;	Family	This region is important for the mating type dependent binding of Y protein to the A alpha Z protein of another mating type in Schizophyllum commune [1].	25.00	25.00	57.40	234.00	20.90	19.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.31	5	6	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	2	0	1	6	0	146.80	51	15.97	CHANGED	MsDpLusL+uISAsAKuMsulAtSRGApssPsPhssTsV+..FDPLPoPsLDuLRoRLp-A+LPPKulKSALuAYEcACuRWRp-L-EuFcpTA+SVSP+NLHLLssLRaRLYTcQVEKWtsQVLQVPE+W+AEMEKQRAHIsATMGPu	Ms-hLusLpuISAsAKsMhulAtSRGApss.pPhssTss+..FDsLPsPsLDhlRoRLp-A+LPPKulKuALuAYEpACuRW+p-L-EuFcpTA+SlSP+NhHLLspLRhRLYscQVpKWhhQVLQVPE+W+AEMEKQRAHIsATMGP.s	0	1	1	1
+1062	PF03417	AAT	Peptidase_C45; 	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	Bateman A	anon	MEROPS	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.28	0.70	-4.90	18	964	2012-10-03 21:14:07	2003-04-07 12:59:11	11	16	794	14	316	1078	61	218.40	21	58.87	CHANGED	hpscss.....hlu+NhD..htPthhssphhlhts..............sGasslsh...supl..Gps.GhNcpGLshsh........Nhhph+ph.ssGhsphhltRhlL-.ssols-AlchLp-h....PctuuhsalhlDpstphshlElsssstsh......sl+css..thhhpTNHh..........................ppshppts......pphhcsShpRhp+hpphhspttss...ppshchhsDtpst.hs.....pphsshtsTla...oulaphtstphphslupsst	..........................................................................hp....t.....hhs+N..aD........hps..t...h...h..s...t...t.h...hh.hh..................................suh.s..t..l..s.................su.tl....Gp...h...t.GhNcpGLsh..sh...................N.h...h..p.....t....c..p...s..........s..s.....G.......h......s..t..h...h....l...h..Rh.....lL-.spslsEA.lp....lL...cch..............sttu..u.......h.sh.hl..h...D...p.s.....t...s...t.sh..l.E...hssp.sh..........................slt.ss.......t.hhp...T.NH.a......................................................t....h....h...p...p....s......................p.h...hp..p...S..h...p..Rh.......t.+h...tp...hhs.pp.sh.............ttsh.......p.......h.h.p.s.t...t.....hs............................h...p.....p.....h.............s....T..lt.............oshap.p..phph.hh.st...h................................................................................................................................................	0	115	199	275
+1063	PF02496	ABA_WDS		ABA/WDS induced protein	Mian N, Bateman A	anon	Pfam-B_2496 (release 5.4)	Family	This is a family of plant proteins induced by water deficit stress (WDS) [1], or abscisic acid (ABA) stress and ripening [2]. 	25.00	25.00	28.10	28.10	23.00	19.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.93	0.72	-3.81	17	393	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	64	0	39	374	0	70.70	70	52.27	CHANGED	.cY+KEEKHHKHhE+lGcLGAsAAGAaALaEKHcAKKDPEHAH+HKIEEElAAAAAlGAGGaAFHEHHEKKEAKcEpcEu	..........-YcKE.KHHKHLEclGcLGAVAAGAaALHEKHcAKK.DPEHAH+HKIEEEIAAsAAVGuGGaAFHEHHpKK-A+cctct...............	0	1	18	30
+1064	PF00950	ABC-3		ABC 3 transport family	Bateman A	anon	Pfam-B_1591 (release 2.1)	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.50	0.70	-5.09	16	7614	2012-10-02 17:14:55	2003-04-07 12:59:11	12	12	3931	0	1534	7023	2698	251.50	28	90.95	CHANGED	pacahppAllsulllulssulLGsallL++hSLhGDulSHusLsGVuluahLuls.....hhhGAhhhulluAlshsalcppo+l+pDsslGIlhushhulGllllolhpt....spssLtpaLFGslLulsppDlh.htllssllLlllllha+chlhhoFD.shApshGlslphhphhLhhLlulslVsulpsVGsILVhAhLlsPuusAhhhs+shcphhllAsllGhloshsGlhlSahhs.suoGssIVlltshlFlluhhht	.................................................................................................hpFh.pAh.ls.ulhl..u..l.s.s.u.h.l.G.s..a..l..l..lRp...h...ohh....G.D....ul...S.H..u....sL........s....G.....l....A...l...u..h...h......l...u.hs..........................hl..u....u.....h...l.....h...u...l.....l...s...A....l....h.......l....t....h......l.......p.......p.....p....s.......p....h...p.....p....D.......s.....s.....l......G.....l....l...h.....s.....s...h...h.....u...l......G.....l.....l...l.....l.o.h.hs...................sss.s.L.......s...h...L...F...G..........s..l...................L............u............l............s.........................p.............D............l............h...........h............l...........h...l....lu...s.............l......l.........l...h.....l..l.h.lh...a...+...p....Lh.hhoF...D.ph...Ap..s.t.G.l.s....s....p..hl.ch.l...hhhllulslssuhpsVG...slLlsuLL...l...hP....u.A....s.A.h.h.l....s..c..s...h..p.....p....hhh.l..us.hl.u....h....l....u.s....h....h......G........l....h........l...S.............a....h........h.............s......h...........s.....sG.....ss.I.Vl.h..ts...h.lFllshh.t.................................................................	0	472	958	1282
+1065	PF01061	ABC2_membrane		ABC-2 type transporter	Finn RD, Bateman A	anon	Pfam-B_865 (release 3.0) & Pfam-B_31 (release 15.0)	Family	\N	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.52	0.70	-5.17	298	15925	2012-10-03 10:13:34	2003-04-07 12:59:11	19	140	4416	0	7264	20686	4522	204.80	15	46.78	CHANGED	pphtslhtRphh..phh+ss.ht.h........hphhps.llhsllhGhlaht.............t....thh.th.................huhlhhslhhhsh.shssh.shhhpppshh.h+phstshhphhshhluph...lsp.lshshlhshlhhh.lsah....h...h....uhpht..........h.....hhhhhhhhlhhhhhsu.huhhluuhs.shp.sshls.shlhhshhhhuGhhhshspl....s.....ahp..a.hhhlsPhsashpu.hhhs.h	..............................................................................................................................h..hhhlhh+phh....thh+.s......h...h..h...................ht.hlt..s...h..l....h....h.l..l...h.....u.h..l..a.h.t.............h..........s..t.thh...h............................................................................................................................s.uh.lhh.h.h..h..h...h....s....h........s....h...h........s.......h........................h........h..h.....h.....t...p....p.......shh....h.......+............h...s....t...........s...h.........s....h.....h.s....h.....h.....h..u.ph..................l.st....h...s.....h.........s...........l..l...h...s...hl.h...h...h...l...s..hh...........................h.....h...........................u.h.pht.............................th...........hhh.hh..h.h....h...l...h.s.h....h.......hss....hu.......h.h...l....u.s..........h...s........s..h.....p....s...s..s..h........l..s....s....h.l....h..h....h..........h...h..........h...h.....u...G.....h..h.h...s......h...s.........th......P....................h...h.p.........h..l.h.....h.h.sP.htahhpu.ht.s................................................................	0	2247	4566	6342
+1066	PF00664	ABC_membrane		ABC transporter transmembrane region	Bateman A	anon	Pfam-B_2 (release 2.1)	Family	This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (Pfam:PF00005) have two such regions.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.40	0.70	-4.99	70	51056	2012-10-02 13:23:42	2003-04-07 12:59:11	18	190	5230	28	16541	42384	7093	265.40	13	43.23	CHANGED	lhhshlhthlsshhthh...hshhhuhhhsh.............hsssstp....................psshhhhhhh......................hlhhhhh..hshhhhsh.has..htthst+lptplhpp.lhc.phhp..h..s......pppssGplssRlosDssplpssl.stplhhhh.tslhhhlsshllh...hhh..uhpLsLlhl.hhslhhhhshhh.sphhpphpppppps.........hsp.hss....hhpEslsulcTVpuastppthhpcappthpp.hpptshptshhsshhhs.htphlhhh.h.shshhaGs..hl...shtsths..ssplh.sshthhthhttsl	.................................................................................................................................h....hhhhh.h....s.h.hthh.........s.h...h....h..t.h..h.ls.......................h.tt.t..................................................................t..h.h..h..h..hhh....................................................................h.h..h..h...h....h..h.......t.s...h.......h...h.....h...h...h...h..hh...................h.t.t....h....u....h....p.....h....t..........t......p....l....+..............p.p.....l....h...p....+..l..hp.........hs.h....s.hh..........................pp.p.s....s......G...........p....l....h.....s..........+.......h....s.................s..............D..h....p....p....l.....p.....p................h....h...s.........p..h....l................t....h.................h......t....s..h....h..............h..h..l.....s.......s...l..h..h.h................h.h.h........s..h..t...l....s....l...............l..h...l...h...h...h..s....l....h...h...........h...h....h..........h.........h....h.....t......p..........t...........h.......p...p...h...t.......p.......p.h....p...p.t.....................................................hup...hs..s...............h.h.p...E..s....l....p....G...h..p.....s......l.......+...s...........a.....s......t.........p........p........p...........h....p.......p....h.....p....p..........t................p.......p....h.......h....p...t...........t......h............p.......h........t........t.....h....t.............s.....h..h.....t..s.....h....h..t.........h...l......h........h.......s.....h....s...h.....h.h..h..h....uu..........hh..............h.h.t.s......p.....h...s........hG..t..h...h....s.h..h...h.h..h....h......................................................................................................................	1	5333	9845	13729
+1067	PF00005	ABC_tran		ABC transporter	Sonnhammer ELL, Bateman A	anon	Prosite	Domain	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes.  ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664.  These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null --hand HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-3.87	55	363409	2012-10-05 12:31:08	2003-04-07 12:59:11	22	730	6447	300	93265	270413	81790	147.80	27	41.67	CHANGED	LpslshslptGchlullGtsGuGKSTLLphlsGhhpP.....spGpl.....................hhp.spsht...........hpthcppluhl.Qp..splhspho.lt-slh.s..........................................hhthtppttpsc........hpphlpplshht..........................hhcphl..............tpLSGGp+p..RlslA+slhppsplLlLDEPTs	.....................................................................................................................................................................................................................................................................................................................................................................................................cslsh.p.l...p...p..G..c.h....l...u....l.....l...G....s..s............G.......u....G..K........S.....T....L.....l.........c.....h.....l....s......G....h...h....p..s........................s.s.....G.....p...l....................................................................................................................................................................................h..l...s....G....p....s...ltp....................................................h.t....t..h.....p.....p.....p.....l.......u....h.....l......h...Qp.........hs.L..h...s....p...h...s....lt-slthsh....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................thtttptppc....................h.p...p..h..l.....p...t......l....s..l.t.t....................................................................h....p....p...h......h........................ppL..S....G...G........p.......+......Q.............R........l..........s..l....A.....R.......A........L...........h............p............p...........P..........c..........l......l.......l.l.....D..EPT...............................................................................................................................................................................................................................................................................................................................	0	28903	57358	77150
+1068	PF00561	Abhydrolase_1	abhydrolase; 	alpha/beta hydrolase fold	Bateman A	anon	MRC-LMB Genome group	Domain	This catalytic domain is found in a very wide range of enzymes.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.07	0.70	-4.80	48	9019	2012-10-03 11:45:05	2003-04-07 12:59:11	15	58	3408	175	3041	47284	15466	242.40	13	59.97	CHANGED	acllshDhhGhGtSs..................................................hsthshpshsc.lptlhp.phshpp......hhllGaShGGhluhthstphsp....plpsll.hhss......................................................................................................................hhhtpshhtt............hh.thhhshhhshhhsshpthhstth................htshpp..hsphhptht...hpshhp....shthsshht.................htthhttshhthhpp......hpsPslllhuppDp...hhs.pst.t.htphhsp.......s..phhhhss..uHhs........hhppssph..sphlhs	..........................................................................................................................................................................................lhhh.s...t.G..s.sh..us....................................................................................................................tht..h....t....p....h....s.......h......p....c.......h......s.....t.........s........h........c......t.......l........h...........p......t........h......G.......h....cp................hsh....l.G.t.S.h..G.G....h.....h.....s....h....t....h....h.....s......p...h.Pp.................pl....p....s...h..l...h.h.us.h..............................................................................................................................................................................................................................h...h...t..t..t.....ht...............................h...t..h...........h...t...........h......h....t................h.....h......t...............t................h....s.............h......................................................................................................h............t..................................t..................ht...................hh...................................h..h....h.......................................................h................t...s.......................h.tt.....................................ht...h....h....h....h..h.....t..h.....t.....p..D.................h.h....s................t..........................t......................t......h.........t...............................h........h.........t.......tH................................tt...........................................................................................................................................................................................................................................................................................................................................	0	897	1658	2474
+1069	PF03806	ABG_transport		AbgT putative transporter family	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	19.60	19.60	19.60	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.73	0.70	-6.50	9	1493	2012-10-02 15:12:49	2003-04-07 12:59:11	8	3	1103	0	203	1520	191	425.00	40	96.44	CHANGED	RFLshlE+lGNtLPcPlhLFhhhhllLhVsSuIhSshuhSsssPhs.Gst...........hlplhsLLos-GLthlhsshlcNFouFsPLGlVLVsMLGlGlAE+SGLluALh+shlppsP++lloshllhlGllSpsAuDAuYVVL.PLuAhlFhulGRHPLAGLAAAaAGVSGGFoANllluthDsLLuGhTppAAphIDPsa..ssNPhsNWYFhsASshVls.luhaVT-KlVEPRLGsapss.tppptspht...lTstE+KGL+aAGluhllhlALh.shsllPtpuhLRs.cssslt.soPFhpulVshIhllFllPGlVYGhlstol+sp+DVsshMu-uMuoMGsYIVlsFFAAQFVAhFsWSphG.llAVtGAchLcshsLsG.sLlluhIlluuhlNLhIGSASAKWulhAPIFVPMhMLlGauPEhoQAAYRlGDSlTNlITPhMsYFsLlLshsp+Yc.chGlGTLlShMLPYSlsFhlsWhlhhhlWhh.LGlPlGPGushtY	.....................................................................................................................................................................................................................................................................................hLshlEhhGN.tlPcPhhLFhhhhlhlhlhohlh..uh..hs.h.s..sh.pP.............t..t......................................l...hl...h...s..L..L..ss..-....G....l....p..h....hlss.hlpNFs.sFs..P.LG.hl.......LshhlG..l.G...lA..EcoGhlssh...hhthl.t...t..s....s....t...p....h..lo....hl...l...h..h.ulh....u.p....h..A...u.D..u.u.....h....V.....l.....l...PluAhlFhuhGRHPlAGlhsAaAuluuGas...ANl.l.lss.hDsLLsGhop......t......A...A.......p...h..l...s..s...s...h......pl..s..s...h.sNaaFhhsSshllshlshhl.T...-Kl....l...c....P+..L............u.p........h.....p......s..........s...................................t......p........p.........h................p.................................lT.t.Ep+uL+h.A.s.l.sh.ll.h.l......sl.l.hhh.h.....lP..................p...s.uh.LR..s...st..s...........t.............h..l............h...suPhh.p.uIl.slIhlhFhlsGlsYGhsstph+....sp....p....Dlh.p...................hMsc....s....h....p.s..M..u.s.a.I.V....hsF..hsAQFlA.h.F......s.a.S..N..h.G..t..hhA.l.....tG..Ac..hL...c.s.......s..hsG......s..hhlu......h.l.ll.s.u.h.lNhhluSuSApWulhAPIFVPMhMhl...G..hpPthsQhhaRlGDSsoN.l....oP....h..sah..sLll.s.a....h..p.+Y.....p..............c.............p....ht..lG.T.lh..Sh.hlP.Yol.hh.hl.sWhlhl.l..hWah..lGlPlGPGs....h.............................................................................................	1	57	123	167
+1070	PF02230	Abhydrolase_2	abhydrolase_2; 	Phospholipase/Carboxylesterase	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_1382 (release 5.2)	Domain	This family consists of both phospholipases [1] and carboxylesterases with broad substrate specificity, and is structurally related to  alpha/beta hydrolases Pfam:PF00561 [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.31	0.70	-4.90	12	2930	2012-10-03 11:45:05	2003-04-07 12:59:11	11	32	1915	13	1262	4011	3116	197.40	21	84.53	CHANGED	hs..tlhsstp.tpsslIaLHGLGDsu.....cuhu.sht.thsh.pspaIhPpusp.hPlshstGht..uWF-lhshs.st..p.spssltputpplppLl-t-hcpG............lssscIllGGFSQGuhluLassLop.p...luGlluhSuhhshttph.pt.stss...phPlhpsHGppD.llPhthGttstchLpshht..psphpsapthuHu.sspphpsltpalpphl	....................................................................................................t............t....t..p..t.h..l.l.h.lHG....h....Gsss.................ph.h......s.........h..................p...........................h.......................h...............t............h......p.h....l..h..s..p..u.....s.......h........................s..........s...............s............t.....G.......h....................................t....W..........a..............s......l.........s.......h........s...........ps........................c.....t.........t............tl...p..t.......s.....h.t...t.l..t.p.....h..l..c.p....t....h...p.p.s..........................l.s.s.p..c.l....h....l.sGFS.Q..................Gu.......s.h.u.............lt..s...s...........h...........p...........t............s.........t..........................h....u..........u...........l.....l...u....h....S...........u..............h..................h...................s.................................................p...............h................t.........t......................................p..........s.......................t.............t......h.........s.....l......h.h.h.HG.p..t.Ds.l.l...s.h.t..h.u.t...t.s.t..p....h.Lpphuh.............plph...c...h..........h...sH......t....l..s.......p..php..hhpalt...h................................................................................................	0	362	705	1015
+1071	PF02517	Abi		CAAX protease self-immunity	Bateman A, Bashton M	anon	Pfam-B_1073 (release 5.4)	Family	Members of this family are probably proteases (after a isoprenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein to attach it to the membrane, the AAX tripeptide being removed by one of the CAAX prenyl proteases).  The family contains the Swiss:Q03530 CAAX prenyl protease. The proteins contain a highly conserved Glu-Glu motif at the amino end of the alignment. The alignment also contains two histidine residues that may be involved in zinc binding [1]. While they are involved in membrane anchoring of proteins in eukaryotes, little is known about their function in prokaryotes. In some known bacteriocin loci, Abi genes have been found downstream of bacteriocin structural genes where they are probably involved in self-immunity. Investigation of the bacteriocin-like loci in the Gram positive bacteria locus from Lactobacillus sakei 23K confirmed that the bacteriocin-like genes (sak23Kalphabeta) exhibited antimicrobial activity when expressed in a heterologous host and that the associated Abi gene (sak23Ki) conferred immunity against the cognate bacteriocin.  Interestingly, the immunity genes from three similar systems conferred a high degree of cross-immunity against each other's bacteriocins, suggesting the recognition of a common receptor. Site-directed mutagenesis demonstrated that the conserved motifs constituting the putative proteolytic active site of the Abi proteins are essential for the immunity function of Sak23Ki - thus a new concept in self-immunity [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.29	0.72	-3.85	1333	12845	2012-10-01 21:07:14	2003-04-07 12:59:11	11	37	3734	0	2636	9172	1289	110.90	21	43.17	CHANGED	hhhh.......hhh......hlh.......................................................hslh...ss.l..........sEEllFRG....h...l........................................................................................................................hs...t............................................................................ltph............hh..........................hhulllou.llFul.hH..............h...........................hh.....h..................................................................................................lhh..hhh....G...l.....hh......u.....h....lh...........h........po..t..s...............lh.sslhhHhhhNhh	.................................................................................................................................................................................................................................................................................................................................................hh...hhhhlh......................hslh...ssl........sEEl...laRG....h....l.........................................................................................................................................................................................................................................................................h..s..t.............................................................................ltpt.........ht..........................hhulllou..llFu.l.hH...hst..............................h.h.....h..................................................................................................lhh...hh..h....G...l.....lh......u........h....la...........................h......po...p..s...............lh....ss.l.hhHhhhNh.........................................................	0	995	1783	2287
+1072	PF03992	ABM		Antibiotic biosynthesis monooxygenase	Yeats C	anon	Yeats C	Domain	This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is  suggestive that the other proteins function as  multimers. There is also a conserved histidine which is likely to be an active site residue.	21.90	20.90	21.90	20.90	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.39	0.72	-3.94	114	8140	2012-10-02 00:20:33	2003-04-07 12:59:11	11	50	3128	85	2223	5804	1847	77.50	17	63.08	CHANGED	hhhlhsphp.lpsspt.ppahph.hpphsp.......hhtspsGhlphplh.........p....s..hpsssp.ahlhphWcs...psu.hpsatpo.........spapphtpt	.................................................hhhhsphp..lp.s.spt...pphhpt..h..p...p..h..ht........th..ppps...G.hlshplh.....................p...............s...hps.s..s.p..h..h...h...hp..t.....Wc.s.......ppu...h.p.s.a.t.p.o..........spapth...t..........................................	0	615	1296	1802
+1073	PF00887	ACBP		Acyl CoA binding protein	Bateman A	anon	Pfam-B_864 (release 3.0)	Domain	\N	21.90	21.90	22.20	22.30	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.06	0.72	-4.32	101	1677	2009-01-15 18:05:59	2003-04-07 12:59:11	14	62	583	29	963	1596	101	85.20	32	33.64	CHANGED	hpppF-pAsphl+pLsp........pPos-phLcLYuLaKQAT.G.css..ss+P..Ghh..............Dhhu+sKW-AWppl..cGh........S+--AhppYlchlpp....lhp......phu	.................................ptpFptAs.ph.l.c.p..Lsp...................pPss.-phLcl..Y..uL..YKQ..ATh.G.sss.............ss+P.....Ghh.............................D.hh.u+s..KW.....-.....A.Wppl....puh.......................o.p--AhppYlphlpplht...t........................................	0	305	482	749
+1074	PF03255	ACCA		Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit	Mifsud W	anon	Pfam-B_1935 (release 6.5)	Family	Acetyl co-enzyme A carboxylase carboxyltransferase is composed of an alpha and beta subunit.	21.30	21.30	21.40	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.66	0.71	-4.64	15	3540	2012-10-02 13:07:06	2003-04-07 12:59:11	9	7	3419	3	719	2292	2130	133.30	51	41.80	CHANGED	hhL-FEKPlhELEpKIspLcclup....cschslssclppLcc+hpcLp+cIausLoPaQRlQlARHPcRPoTLDYIptlh--ahELHGDRshuDD.AlVGGlG+lcG+sVslIGHQKGRDTK-pltRNFGMssPcGYRKALRLMchA-	........................................................p..L-FEpPlh-lct+IppL.p...h.tp............p.........t....l....s........h..s...p.ElptLcp.+.........p..htc.....c...l........a......s..sL..ssWphsQl....ARHPpRPhTLDYlptl..F..s..-..Fh..E.....LHGDRs.au....DD.t......AIVGGl..A........+.l.s........G........p........P........VhVIGpQ.K.G............+cT..K...........-plpR........NFGMPp...PEGYRKALRLMchAE..............................	1	237	478	613
+1075	PF00871	Acetate_kinase		Acetokinase family	Bateman A	anon	Pfam-B_1595 (release 2.1)	Family	This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.	22.00	22.00	22.00	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.10	0.70	-5.93	11	6003	2012-10-02 23:34:14	2003-04-07 12:59:11	12	14	3886	38	1171	4042	326	366.90	38	95.86	CHANGED	KlLVlNsGSSSlKFpLh-s........ptpsLhpGLsEpIhlssuhhhhp..stcp.tthsshssHptAlphllssLpp...thhpphs-IsulGHRVVHGGphFosSslls--llcsI+DhhpLAPLHNPApl.GIctstclhPss...pVAVFDTuFHpThPptAYLYulPhshhpcaGlRRYGFHGTSHKYVup+suchLsKPh-pLslIsCHLGNGuSlsAl+sGKSlDTSMGhTPLEGLhMGTRSGsIDPAIlsalt-ppshSss-lsshLNKKSGlLGloGloSDhRsl.-shpc.ucccAphAlchasaRlt+aIGpYhAsLt.splDulVFTuGIGENuuhlR-hhlpsLchlGlclD.EpN.h..phGccslISossS+hplhllPTNEElhIAp	...........................................................................................................h.lLllNsGSSSlKatlh...chs......................s.t...p....h...l...h...p.Gl...s....E.....p....l...s...h...p..s...u...h....h...p...................h..p....................................s..............s.......c.......p..........t....t.............h.....s....h..s......s.....H....p....tA...l....p.h.l..l.p.tLhp..........t..h..h...p..t...h.....s......pl.s..ulGHRlVHGGch.F.s.posll.....s..-.....cV...lp.p.I.c.c..hs..s.L.......A..PLH.NPAslh..........GIcss....p...cl..h......P.s.ls.........pVAV.FDTuFHpTMPctAa.hYulPh.ch.Ycc.....hslRR..Y.GFHGTSHpYVu...pc.u.A...c.h...L.....s..+..............s.......h..................c...clplIssHLGNG.u.SlsAlc.....sG+SlD.TSMGhTPL-GlhM....GTR.SGDlD.P.ull.a....l....h..........p.........p.........t.............s...........h...o........h.c.............c.l..............p....c...lLNKcSGLLGl.o.G.ho.o.Dh...Rs.....l...c...p.............sh...............t...........p.....G.........c............c......c...........ApL.A.h-hasaRltKaIGuYs.A.sh................t.........lD..AllFTuGIGEN.ushlRph..lh.p.t.L.t....h..h......G.l.p...lD.c.tN..t.......hhG..p..p...t..h....I...s....p...t.s..o.p.....l.h.s.hVI.PTsEEhhIA...............................................	0	390	748	994
+1077	PF02550	AcetylCoA_hydro	Acetyl-CoA_hydro; 	Acetyl-CoA hydrolase/transferase N-terminal domain	Mian N, Bateman A	anon	COGs	Domain	This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA.	20.70	20.70	20.70	21.40	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.20	0.71	-4.55	5	2652	2012-10-04 00:26:15	2003-04-07 12:59:11	10	14	1717	21	626	2072	95	179.70	26	42.46	CHANGED	hpcpYp+Klts.PEEAAsLlcsGpHIchGGhhuAuTApulPcYLA+R+sEhspl+ssohIDLtshphloAuPps-hhcpcsuhlaR.ss+pouchsssslNpGllcasshaLSElut..hhspGFss........IDlAlIpTTshDcHG..alNhG..Vo......ssthKuIlEl........AElVllVlssssPalNG.YDthIsl-+V..DYIltDsEhsVshlP	..............................................................................................................................t........hhhs..st.cA.s.th.l..pps...........hlshut....su.sts.ls.....A..ls......p..h..............t...h.t...........h.....h..p......l..h.h.h.t.............s....s....t..t.h..h..t........t.hh.t.h+........sa....s.s.......h.....R.c......t....Is.....p......G..p......s....as.s.h....+LSc.lsp......hh.c.p.s...hhs.....................lDVAllp.........s..ush.sccG.....ah..s.....G..lu............sp.tpp.s.ll.Eh................uth.h...l....l.s.t.s.hP+.p.hu.hs...h..h....h..t..h..s+l...s.h.lh...ss...........................................................	1	243	430	562
+1078	PF00797	Acetyltransf_2	Acetyltransf2; 	N-acetyltransferase	Bateman A	anon	Pfam-B_575 (release 2.1)	Family	Arylamine N-acetyltransferase (NAT) is a cytosolic enzyme of approximately 30kDa. It facilitates the transfer of an acetyl group from Acetyl Coenzyme A on to a wide range of arylamine, N-hydroxyarylamines and hydrazines. Acetylation of these compounds generally results in inactivation. NAT is found in many species from Mycobacteria (M. tuberculosis, M. smegmatis etc) to man. It was the first enzyme to be observed to have polymorphic activity amongst human individuals. NAT is responsible for the inactivation of Isoniazid (a drug used to treat Tuberculosis) in humans. The NAT protein has also been shown to be involved in the breakdown of folic acid.	21.00	21.00	21.10	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.49	0.70	-4.79	33	2001	2012-10-10 12:56:15	2003-04-07 12:59:11	12	6	1363	31	435	1384	26	229.20	28	85.40	CHANGED	sL-oLpplhttHhpulPFENLslhhG.....csl.sL-lpslacKlVpp+RGGaCaEhNtLhthsLpplGFclshLuupVhhstsst..ssshoHhlLhV.sl-Gc..salsDVGFGus..phhtPlcLtsstsQspshu.hFRl.scpss....tahLpphppppWh.................slYpFslpPpshpDapsts.hahpopPsS.hFspp..hlsuhtss-.GphsLhupphohp....psst..thphphlsssEltcsLpphFslsls...tthl	..............................l-sLptlhhtahtslPF..EN.L.s...lh.h.s...........................p.l..pl...s........psL..hcKl...l........h......p......p..R....G..G.aCaEhNslFthhLpp..lGF.sVphlhu.....pV.........h.....h.........s............s....s.............s.............t..............h........s........s...t.............s.......HhhLlV......s...........l.........c.sp...........palsDVGFGut...h.htPl..L.....t.s......s....h.....s................s....s....t....s.....paRl..h........ppss.................ha.hl..p....t.......t......p......p..p....p....Wp........................................shY..pF..s....h..p.......p.....p.D..a....t.........sp...hast..p..p..P..pS....hF.tpp.........hl..h.......s....p.....h..........h........s.........s.......G.............+..............h.....s...L.s.....s..t..........p......hshh..................tss....hpppp.h.s....tphhphLpp.F.ultl...........................................................................................................................................................................	0	133	234	337
+1079	PF00328	His_Phos_2	acid_phosphat; Acid_phosphat_A;	Histidine phosphatase superfamily (branch 2)	Finn RD, Griffiths-Jones SR, Rigden DJ	anon	Prosite	Family	The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches.The smaller branch 2 contains predominantly eukaryotic proteins.  The catalytic functions in members include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase.  The in vivo roles of the mammalian acid phosphatases in branch 2 are not fully understood, although activity against lysophosphatidic acid and tyrosine-phosphorylated proteins has been demonstrated.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.16	0.70	-5.12	93	4055	2012-10-02 11:42:54	2003-04-07 12:59:11	17	54	1206	64	1934	3581	41	323.30	15	63.62	CHANGED	pLchVpllhRHGsRsPppshstp..t................................................................................t..h.t.hta...................................................................................pashshGt...........LTst.GttpthphGchhR.p+Ys.................tLhsst........pplhlhoostsRsltSApshhtGhh.sps.............................pshshthlsc...t.sshhhhst.........tsCsthpp......................ppsspthpphppthtpshs........tclsph...................................su.....shshtcshshhshshhppt.................................phpshssl.hsp.....tchhphph..............................................................................................................................hpslpp......hath.............uhspt....htphhGsshhsplhpplppshsppp..........................................................................phphhhhhuHDoslhslhs.sL....Glhpt...........................st.sPauuplhhEha.p.......................ssp...t....hhV+lhhs	................................................................................................................................................................................................lp.l.hl.RHG.Rs.Ph.tt...................................................................................................................................................................................................................................................................................................................................ta.....................................................................................................................................................................th.s..h.thGt.........LT....s....t....Gt......p....hht.hG.phhR.phas...................................................thhp..p.t..h........pplh.hh..u.s......s....pR...s.h.....to............A......ps.....h...h..tGhh.sps.....................................................................................h.sh....t.tht..p...................t..s.th......h.........................tt.ss.th..pp.................................................t.s...t..h..t......t......t....t..t..h...p.ht.....................phpp.........................................................................................tt...............h..t.h...t...h..ht..h...h......h.thhp...................................t.....h..s..p...h...hpt........tp.....tp.hp...............................................................................................................................................................h.t.ph.pt....hat...................................th.s.t.....ht...t.....h...u...t...sh.h...p.....l...hp.tl........tphtp.tt..............................................................................................................................................................................................................phh..hh..hu..........HDss.....l.hs.lhs..sL...........sh..................................................................................................p.ss.h.uuplh..hphap..............p.....................stt.......t......hlph..................................................................................................................................................................................................................................................................	0	702	1050	1602
+1080	PF03767	Acid_phosphat_B	acid_phosphat_B;	HAD superfamily, subfamily IIIB (Acid phosphatase)	Finn RD, Selengut, J	anon	Pfam-B_2784 (release 7.0)	Family	This family proteins includes acid phosphatases and a number of vegetative storage proteins. 	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.47	0.70	-4.99	31	1773	2012-10-03 04:19:28	2003-04-07 12:59:11	9	10	1346	54	323	1170	350	209.70	26	84.65	CHANGED	thpshhshtts.sthtCso....a+.hu...sEspNlhsapshstpshphstpYh..thppaps-.pslsppAhhhAcpht.ps.........sthsshlFDID-TlL.oNhPYhthps.h....Gsctass........pp........as.cWlppGpA.sulst..sl..chhptlhphGhcIhalosRpcs..p+ssThp.....NLpptG.................ap....shc+LlL+s.ps.ps...hpY...KsscRpplhcc..GYpI.............lt......hGDphsDlhG........sspu..................pRsh+LPNPhYhs.	...........................................................s...........................p..................t.tt.s....l......phsu..........hh.ph...p.httt...........................t.hAlshDlD-TlL..ss.ss..a....h..h...........st.c..sa.s.s..........................p.s.......................ah..ch.hp...p..u..t...s...hulPt..sl..phlch.t.p+GspIaalos.Rs...........p..........s.........t..........s.........t..........Thp..........slhp.t.s........................................................ht....sh..s.tl.l.h.t..s...pc....s...........p..s..............................Kts+pphlpcc......hpl................................................................hhh.....hGDs.s.Dhsu..........s+pssscs.......................h+hlhhsNshYts...........................................	0	69	187	257
+1081	PF00330	Aconitase	aconitase; 	Aconitase family (aconitate hydratase)	Finn RD	anon	Prosite	Family	\N	22.30	22.30	22.40	22.40	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.53	0.70	-6.02	11	14106	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	4231	25	4215	11379	9019	338.30	28	64.53	CHANGED	TLhEKlhcuHlst.p..........cpusphLhl..DRhlhp-sTus.Ah.sLtsuGpslppssh..........ohhshDHsIsspsttp......Dlphptshs+cphphLppssKcaulthas.su...GIlHpls.EphhshPGh............TlVssDSHTsstGuhGuLAaGlGsuEsEcVhAsQslp.tpPKshtlclsGKLssGlTuKDlILplhGhlsscGGTGplVEahG-ulssLShpuRhTICNMuhEhGApsGhhs.DEsThcYLcups+A.cutph-cAhshhctLpsDcsA....paDpllcl-hsslpPplshspsPs.shslschssssp.p......t.t.cc..htahshhPt..h.tlcVchuhIGSCTNSphEDlppAAullKpt.....ttlpshshhhVsPGSc.V+sphE+-GLscIFp-sGhphhssGCosClG.s...sDhlps.......tspssoouNRNFEGRpssss+TH..LsSPshssAhAluG	............................................................................................................................................................................................t..h.p-..........h..h......h.......................t..............................................................h...DH..h.......................................................s...........h......h......................................tt..h...t.........................h.........ss.......Glh..H.h.........E..hhhshh............................................................shlssDSHTshhsu.hGhluh............G..........hGs......-.sth.shh.s.tsh.......hs.c.............s.....h..thphp....G.p.h.........thssp...............Dll............Ltl............h......t.......h....h.t......h......t.....t............s............h............G...h...hhE.....a.h..G........u..lt..t.Lsh.tt+hols.NMu.....................Eh.G.A.p.su.h.h..............D.p.............................s....h.......p.................Yl................p.................................p.......................h................t..........................t........................................................h.....................t.............................................................p..................h...........t.....c........ss...........as.t.h..l.p.lchsp...l.t.P.lshspp....Pp.t........hh...ls...th.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................t......ht..l......s.shIsSC.ossp...phhhuAtl...ltt..p.........................t..h..t........h..p..h.lsPuSt......l.....t.t......h........t.....t........t.....G.....h......................thh..p.h...........Gh.t...................h.h.......................u.Cs.......ChG.t.................t...ht.....................................h.hs.h.ossRNF.sR....t.........s...ph......LsSs.hssshAlhG.....................................................	0	1274	2607	3544
+1082	PF00694	Aconitase_C		Aconitase C-terminal domain	Bateman A	anon	Pfam-B_224 (release 2.1)	Domain	Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism [1].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.54	0.71	-4.04	18	9126	2012-10-01 19:37:30	2003-04-07 12:59:11	14	28	4295	33	2735	7034	4256	118.60	33	21.91	CHANGED	hshalphcGhssstthSsssschth.tphpsshsphtlssthhtshchspspph.st-ps.......shhtss.tY+.tsscllVluscNaGsGSSREHAAhu.pthGh+ulIucSFucIacsNLhppGlLPLphsps	....................................................................................h...ah..pGh.h....t.....s.sspct.h..h.hh.tp.h..sp...hth..t..s....t....h..h...............s......h..........c........h......................t.....t.............................................................................shh.s..t.pY...p........s.s.s.l.........llhu.csaG....sGSSREaAAhuhp.hh.G...........l+sVIA....p..........S.....F.u.cI.ap...sNhls..G.l.L.Plph.t.s..................................	0	835	1673	2276
+1083	PF01756	ACOX		Acyl-CoA oxidase	Bashton M, Bateman A	anon	Pfam-B_598 (release 4.2)	Family	This is a family of Acyl-CoA oxidases EC:1.3.3.6. Acyl-coA oxidase converts acyl-CoA into trans-2- enoyl-CoA [1].	21.40	21.40	21.50	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.98	0.71	-4.92	37	1066	2012-10-01 23:33:27	2003-04-07 12:59:11	14	21	433	8	692	1082	31	165.80	23	25.84	CHANGED	chpss.tshlcAachhstchlpcuspphpp..t.t.s.tpuaspsu.hphhpsu+hHs+hhllpsFhc+ls.....thsstsl+thLppLspLa.uhahlpcpuutFLptuhh..ospplshlpp.tl..cLhsplRsssluLsDuFshsDhhLNSslGpaDGclYcshachsppssssp...tscssaacph..LcPhLp+.	..................................................t.hhpsaphhtt.thltpssp.plp.p...........t..t.t....s.t.hpu.aN.p.st...hphh.....ph.u.pAHsch.hllct.Fhctlp...................ptsss.shpplLppLspLa.uLt.tl..pp.....p..............hu..tal.....pt........s........hl.......os.pp.......h.p.....t.lpp....tl..pLh.spl.....RPp....Al.sLVDu..FshsDhh.LsS........s...............lGt.D.Gph...Ytthht..h.t...............................t....................................	0	256	392	581
+1084	PF00873	ACR_tran		AcrB/AcrD/AcrF family	Bateman A	anon	Pfam-B_578 (release 3.0)	Family	Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer  membrane channel TolC. The structure shows the AcrB forms a  homotrimer [1].	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	1021	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.68	0.70	-13.50	0.70	-7.15	16	19835	2012-10-02 18:57:54	2003-04-07 12:59:11	14	33	3142	84	5307	18191	12148	888.80	26	97.07	CHANGED	hspFFIcRPlFshllAllIhlsGslulhpLPVstaPpIssPsVpVsssaPGASscslpssVTpsIEpshsGlcGlphhoSpS.usGpsslTlsF-pGsDhDhApspVQs+lptApspLPpsV.pp.ulsshcsups.lhshulsSs.......ssshsth-LpsasssslpstLuplsGVG-VplhG.sphuhRIhlDPs+LsphpLThsDVhsAlpspNspluuGpL......sspphphslhspsphpos--accIll+......stsGu.VRL+DVAcVElGu-phshhuphNG.cPAsslslphtsGANsl-sucuV+pclscLpth..hPpGlclshsYDsTsalcsSIcsVscTLlEAllLVhLVhaLFLpNhRATLIPslAlPluLlGTFulhthhGaSlNsLThhuLsLAIGllVDDAIVVVENlpRhltp.puhsP.........hcAshcuhsplptAlluhuhlLsAVFlPhhhhuGssGtla+pFulTllhAhslShlVAlTLoPAlCAhlL+stppscct...........thathFNphFctssptYscslstlL+psthhlllhllllsu.slhLasplPpsFlPppDpGhhhstlQhPsGsShppopplhpplpc.hlp.cpspVcslh.shsGhs..uG..pu.NsuhsFIpLKPhcER.t.pp.ostullp+hptphspl.suslhh.hss.slpt..htsssGhchplts.hhGsuh-sLppstpplhthhtphPs.L....scV+sstpsstPphplclDc-+ApplGlsls-IspslpsAhGu.phlssFhcpuRhhcVhVpsssphR.sP-slsplhVpsspGp.....hlPlouhAohc.shGssplpRhNuh.shpItups..ssGhSsGpAhpshpplhpp..LPsGhshpaoGhuhppptussptshlhslulllVFllLAAhYESashPlslhlslPLullGALLAhhlpGhs.slhstVGllsLlGlusKNAILlV-FAp-hhcpcGhslhEAllpAs+hRLRPILMToLAhlLGhlPLAluoGsGutsppslGhuVhGGhlsuTlLsLahlPlhYlllc	..........................................................................................................................................................................phhlpp..hh.sh.l.ls.l.h.l.h.l.h.G...........h...........h......u...........h...........h.p..........L.....s..........l...p.t.h.Pp.ls..s.l.l.p.s.s.a.PG.A..........ss.pplpppVstslEp.t.h.s...s.l.s..s..l..p.....h..p..S..pS..ptG....u..ls..l....p....F...p.........s.....s...s.........s...h...A...t..........p...V.....pp....tl....p...t.....s...........t.....s...p.....LP....p....s...l...tps.s..l...t.......................p.....s.......s....s....s.......l.h..h.h.sl.hup...........................................................t.h...s........t...p......l...p...s...h......h...p....lp..pl.p.p.ls..G.Vu.p..l.p.h...h....G..t.t.p.hthpl.ls.s..ppLtth.s......l..o..........s.c.l.h....s.u........lps..p.N.h....p..h..s..s..G..tl...........................................pttt.h..p.h....l.p.s.......p.s...........p.....h.......p....s...........h.c....c.....h..tpl..hlt...........................tt.s...G.......s.......................l.p.....LtD.............l...A.p.l.................p......h.............G....................s..............p.............p...............h.............p................................h................s................t.........................h.......................s....................G........p..................................u............s..s.......l.s.l..h.h.t................s.u.u.N.s.lp...s..s..ptlc....t....t...l.t....p....l....p..tt...............h....P.........t.............u.........l.........p............h...t....h.....h...h....D...p.o......h..l...p.....t..u...l...p...p.l.h..p....s.....L....h......u.h....h....l.....V...h..l....V.h....h.l.F..L...t....................s....h...R...u....s....l..l.ss.l....u.l..Pl..sl..l...s.o...h..h..h..h....h..h......h......G......h......o..l.N..h....l...o....L...h..u..l.s.lA..lGh....lVD.DA.IVl.l.E....N....l......+.h...hpp.....s.hss...................................................................hp.A.s.hpuhpplshsl.lu..hsl.s.lhs........VFlP.l.h.h..h..s...G...h...............s.G..t....h.a...p..t.hu....holsh..uh.hh....Shl..lul.s..l.s.P..h........h......s.....u.......h.........h......L...+........t....t..t.tpp................................................................................s.......t.....h...........h....p........t........h.....t.....p...........t.....Y......t.......t....h...l.....t......h...h......l......p.......p.......p....h.................h.......h.....h...h.....h....h........h..............h.........h.....h......sh........s.....h.....h................h............h........h........h...............l......s.....p...................p........F..h...P...p..pD....p..u............h....h.....h..h.ph.s............us...........o.......h..pp.s...........t.p....h.h.......p.p.......h..................p.......p.......h.........l..............t.........p....................................s.........t.............l.......p..............p............h............h.....s.........h........s........G..........h.........s.......................s..........s..................................t..........s................s.................u...............h......h.......l.........t.........L....c....s....h.....p......................p..................R..........................................................................t...............................s.............h...............p......t...........l..........h...t................c................h..................p.t.........t......h.................t..................p..........h.....................s..........s.t............h................h.........h.......h.................t.h..h.............................s..s.u...h.......p....h....l........t...........h....h.h.u.........s...h...p.t.Ltp...h.s..p..p....lh...t......h...h........t......p........s..t...l..............ss...l...p.....s..s.....h......t.....t.s......tsp.hplplD..p.ppAtth......Gl..sh.ss.l.s.p....s....l.....................p..s..s......................h...u.u....t..........l...........s...........p.....h....h.....p........t....s..........p...............h...p...l....h....l..........p..................h.........s.............t........p...........................R................s...................p.........s...l..p....p...h......h.....l.....t.....s....s...s...G.t....................................................................h..l...P...L...ush...s...p...h.p.....t...u.s.s.t.l.p....+..h...s.th..s..h..p....l.tu..sh.....................s.s...s...............h............s.....h........u.............p.......s....h................p........h......h............p........p..........h............h............p.................p......................................................L..............P......................s.....................G.....................h................t..................h................p................a..........s..................G.......t...s...........p.......p..p....u....h..............s.............p....h..........h...........h................h................h..sh.u....l.lhla.ll.Ls.................h..............a.c.S...hh..P.hh...lh.h...s.lP.hu..ll..G.........u.........l...........h..............u..l......h............l...............h..................s...............h......................s......................h...........s.............l............h....s........l..G......h.lh.L....h...Glss.+NuI.ll.......l........-.....a............h........p..........p.........h........h...........p..............................p..............G.............h..............s.............h...............h.............c............A.....h....h.....p.A.shhR.hRPIlMT.sh.shlhGhlP.l.............h............h............u..................t..................G...............s...............G.........u.t...h..p.............p.......s.......luhslhGGhlsuTlLsLh.h.lPs.h.ahhh................................................................................................................	0	1569	3236	4342
+1085	PF05058	ActA		ActA Protein	Moxon SJ	anon	Pfam-B_5981 (release 7.7)	Family	The ActA family is found in Listeria and is associated with motility. ActA protein acts as a scaffold to assemble and activate host cell actin cytoskeletal factors at the bacterial surface, resulting in directional actin polymerisation and propulsion of the bacterium through the cytoplasm of the host cell [1,2]. 	23.80	23.80	31.70	23.80	21.10	22.90	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.74	0.70	-13.05	0.70	-6.52	2	1025	2009-12-16 10:43:18	2003-04-07 12:59:11	7	3	37	0	1	762	1	335.50	65	99.41	CHANGED	MRAMMVVFITANCITIsPDIIFAsTDSEDSSLNTDEWEEEKTEEQPSElNTGPRYETsREVSSRDIKELEKSNKV+ssNKADLIAMLKtKAEKGPN.NNNN...SEQotNsAINEEASGADRPslQVERRHPGLsSDSAAEIKKRRKAIASSDSELESLTYPDKsTKsNKKKVAKESlsDASESDLDSSMQSADESoPQPLKANQQPFFPKVFKKIKDAGKWVRDKIDENPEVKKAIVDKuAGLIDQLLTKKKSEEVNASDFPPPPTDEELRLALPETPMLLGFNAsATSEPSSFEFPPPPTD...................................sELEIhRETASSLDSSFTRGDLASLRsAINRHSQNFSDFPPIPTEEELNGRGsRPTSEEFSSLsSGDFTDDENSETTEEEIDRLADLRDRGTGKHSRNAGFLPLNPFsSSPVPSLSPKVsKISAPuLlSDITKKsPFKNPsQPLpVFNKKTTTpTVhKK.TPVphAPKLApLPsTKPQETsltENpsPhhEKQAETNpQsIsMPSLPVIQKEsTEpsKEEMKPQTEEKMVtESEsANssNGKpRSAGhEEGKLIAKSAEDEKsKEEPuNHTTLILAMLAIGVFSLGAFIKIIQLRKNs	.....................................................................................................................................................................D.LIAML......KtKAEKGPN.NNNN.....uEQotNsAI.N..EEASGsDR........Psl.QVERRHPGLsSDSAAEIKKRRKAIA.SSD.........SELE......SLTY..........DKPTKssK+.K.VAKtSVsDsSESDh.....tSphpSsD.ps....KtsppPFFsKsFcKIKtAGpWshDKlscNPt....................cpEEVNAS.DF..P..PPPTDEE....L......R...LAL.PE.TPMLL....GFNA..........P.ssSEP....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+1086	PF00976	ACTH_domain		Corticotropin ACTH domain	Finn RD, Bateman A	anon	Pfam-B_1057 (release 3.0)	Family	\N	20.70	20.70	21.10	21.00	19.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.14	0.72	-4.11	13	1273	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	737	0	33	1256	0	38.60	83	21.34	CHANGED	SYSMEHFRWGKPsGRKRRPIKVa.sNuh..E..-ESpEsaPhEh	..SYSMEHFRWGKP...V.G.KKRR..PIKVF.PoDA...E..EESSEhYPhE.h..............	0	1	4	13
+1087	PF00022	Actin	actin; 	Actin	Sonnhammer ELL	anon	Prosite	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	393	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.26	0.70	-6.05	28	15168	2012-10-02 23:34:14	2003-04-07 12:59:11	14	83	3849	392	3857	12329	1523	241.30	43	92.30	CHANGED	u--lsulVlDsGotss+AGaAG-DsP+..........slhPohlG.....+spsst......................................chhlGsp...thp.....csthplppPh.ccGllpsW-shcclWcashhpc.Lpss........P......................................p-+PlLlTEsshNspppREKhsElhFEpapsPAhalupssVLotaAsG+s..................TuLVlDsGsupTslsPVa-GasLp+ult+.sluGchLoppl.ppllpp.......h.h...........h...........................s.SapshtcppllpchKEslChVs.s....................phptus...........s.ssps......Y....cLP.DG...............................................p..phhhGs-RFplsEhL.....FsPshht.ptt................................GlscllhsulttsD..sDlRtsLhuslVloGGooLhsGhs-RLppElpph................s.ssh.....+l+lhAss...ER+ausWlGGSILASLu.oFp.phWlSKpEY-EpGss...lVc++Ch	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....................h...t.h.......................................................................................................................................t..p....p...........h....l...l.........o...E.s.............s.........h.........s.........s...........................t...p...R...c......p...............h....s..........p........lh......F..E.....p.a.s......h...s.u.....ha.l.......sh..pu..l.L.....u..l.....a...u...s..G.p.s..........................................................................................o.G..l.Vh..DsGcu..so...p.s..lP.l..h...-......G........h........s..l...s...p..........u...l......h......+..l...s......h.........u.G.c..c.lTp.hh.hplL.tp.......................p................................................................................................................................................................t...h.....t.....t.p.h..cl..l...c...p...h...K.....E...p..h..s..a.l.u.shpt.....................t.t..ts.........................................................................s..t..p..p.........a..........p..l....P...D...G..........................................................................................................................................................................................................................................................................p.......hl..p..l..u...t...E...R.a..p....s..s...E....hl............FpP.p...hs....p...........................................................................................................ul........h....h.h..p.....s..l..............p.......s...s................h.-....h....+....t.....t...l.h............t.s..h.lh....s.G.G...s...o.....hh...........s....h.........tRh.......tch.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1405	2078	3077
+1088	PF01643	Acyl-ACP_TE		Acyl-ACP thioesterase	Bashton M, Bateman A	anon	Pfam-B_928 (release 4.1)	Family	This family consists of various acyl-acyl carrier protein (ACP) thioesterases (TE) these terminate fatty acyl group extension via  hydrolysing an acyl group on a fatty acid [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.67	0.70	-5.45	27	1578	2012-10-02 20:54:35	2003-04-07 12:59:11	12	8	1264	3	365	2638	846	228.20	24	89.64	CHANGED	GLsa+psFslRsYElGhs+TAolETlhNhLQEsuhNHspslGh.sDGFutT.pMp+hsLIWVVs+hplplpRYPsWGDsVcl-TWstupGKhGh+R-WhlpDhpsGEllsRAoShWVMMNpcTRRLs+ls-EVRsEh.shh.pp..l...--sscKLpKl......-ssu-hhctGLsPRasDLDhNQHVNNVKYlGWlLES.hP.pll-o+ELpslTL-YRRECtpDsllcSlTsht......................sstppsthphpHlLplss......GsEIs+u+T-WR.	.........................................................................................ap.phpl.h...csD.hs..t....p..hpl....sslhphh......p.sut...p.s.t.p.h.G.hs..ph..........hpchsh..sWl.lschplcl......p.R.h.P.p..h..........s.-.p.lp.lpTh.s.h.u.h.s..+...h..a.s..h..R.c.a..t..l...h....s......p.s......G.........p...............l.s.cspoh...alhhshco...R.....+.h...t..p...l..s...s....-.lh.s.a.....................tsp.....p.+lh.+h.h.........hpt..p.p.....h.t.ps.a..p...l..Ra...D...lDhNtHVNN...........sc...Y........l........p........W.......l.........h........-........s..........h....s.........h.......c.......h...........h........p.........p............t..........t.....................p....p...........l.........p....l.........c..Yh+E.s.t....Gs......lp....................................................tt......h...l............t.............h...a..........................................................................................	0	116	276	331
+1089	PF02770	Acyl-CoA_dh_M		Acyl-CoA dehydrogenase, middle domain	Finn RD, Griffiths-Jones SR, Mistry J	anon	Prosite	Domain	Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold.	20.60	15.00	20.60	15.70	20.50	14.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.35	0.72	-4.45	69	26220	2009-01-15 18:05:59	2003-04-07 12:59:11	14	120	3313	214	9308	22756	9383	53.90	34	11.57	CHANGED	uhuhTEss.uGoDh........tshpTpAptssss.......ahls.....GpKtalos.u..shA....shhllhu+s.s	............................................shuhTE..P....s...uG..S..Ds.................s.u.l.p.....T..p..Ap..p.......su-t...................alls..................G.p.Kh...aIos...u......shu......s.h.hlVhA+s......................................	0	2632	5550	7773
+1090	PF02771	Acyl-CoA_dh_N		Acyl-CoA dehydrogenase, N-terminal domain	Finn RD, Griffiths-Jones SR, Sammut SJ	anon	Prosite	Domain	The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha  domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.79	0.71	-3.50	988	26175	2012-10-02 12:47:07	2003-04-07 12:59:11	11	97	3435	215	9054	22885	10305	112.70	20	25.73	CHANGED	o.-.......-pc..hl+cs...sRc.Fspc..cl.h..P.....h........stch.....c..c....pp.p.........hP...tc..l..hcch.u.-.h.GlhGlslP......E-YG.G...s.G..h.............s...hhshsllhEElu+..ss...s....uhsh.hhss..pssls.s........l....hpaGo.--QKp...+..aLPtlssG-	.............................................................p.p.hhp.t....scp..ahpp......pl...t.....s.........h...............................h.tph.............-.......c.............ps.....p.........................hP..........pc....h..........h.p.ph...s....c....h....G.h.....h.....u...l....t..l....P...............................cc.a......G.....G...........t..G.......h...................................s...hhp.hs.l.l.h.-El.up.....ss.................s.....u.hsh.......hhss.....t.s.s.ls.h..........sl..............ht...aG.o...c.c......Q..+p...c.a.LstlhpG...................................................	0	2413	5396	7525
+1091	PF02551	Acyl_CoA_thio		Acyl-CoA thioesterase	Bashton M, Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	This family represents the thioesterase II domain.  Two copies of this domain are found in a number of acyl-CoA thioesterases.	20.70	20.70	21.20	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.75	0.71	-4.53	9	1320	2012-10-02 20:54:35	2003-04-07 12:59:11	10	4	888	10	170	2384	900	124.10	41	59.06	CHANGED	hssthFhs-h..p.css.hppsasGphhu...Qshhtu.p.ssP.cDhhlppsh................................HShaFh+sscsschllYslpo........LtpGchF.......sQsGplluo......sspcGh	.........................................................................l.pttFhs-pPhchcP.s.h+.p.s.h...p...GcV.st....pQ..lWl...+...AsG...sl.P....D....D..h....hlH....p...ah.LuYuSDh..sh.Ls.s...A...l.......p...s...Hsl..........uhhp...t.h...p....l...AT..l..DH..S..h..WFH.....R.........P.........F......s........h........s.-W..LLY.............u.VESssA..u..s.uRGhsR..G..cha.......sQsGt.LlAo.......ssQEGl.........................	0	28	69	120
+1092	PF00698	Acyl_transf_1	Acyl_transf; 	Acyl transferase domain	Bateman A	anon	Pfam-B_250 (release 2.1)	Domain	\N	24.30	24.30	24.40	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.84	0.70	-5.10	12	13987	2012-10-02 11:19:24	2003-04-07 12:59:11	16	1271	5013	68	4402	12759	2619	292.50	26	23.26	CHANGED	VaVFsGQGuQWtGMGhpLlpspslFtsultcs-cshps.hGaplh-lLp..sss.......................................................thcpl-hlQPsLhulpluLsplh.puhG..lpPsuVlGHShGElAAuhVsGALo.t-ushslshRuphhtpls.stGuMsuVsh....s..c.h.t.h.splslAssNuPpollluGsp-tlp-hlpphptcs.htsphlsVshAsHSsphsslt-sLtttLup.lsshtsplshauospss.t.....sssphsApYWhpNh+psVpFppAlpuh...h-suatsFlElSsHPlLttulpcshc.........tshssssllsphpRcpss...hppFhtshsphHssGsss	...............................................................................................................h.alFs.G......QGu.Q.hsG....MG.p.p......Lh....p........p...........s....s....ht....p.....s....h....s....p........s....s...p...h........h.......t.....................h........s...........h.........s.......l...h...p....l..lh......s.s..s..t............................................................................t.t.L..s..p....o...p...h...s....Q.P....A.....l...h....s...h....p....l....A......l..h..c....l....h.....p....s.......h.......G.............lp.P...s...h...l....s....GH....S........l......G......Eh........u..Ah.h.....s.AG..........s..........l..o.h...p.....D.....A.......h....p........lV.......t.....h.....R.......u....p.....h........h...............p................p.............h.............s........s...........s...........G..........u.......M...s..A...lhs................................stt..t.....h....h...............t.......h........t...........s......t....................l.......s.......l.A....s.....h.....N...u......P...........s..p...........s............V..lu..G....s.t....p...u..........l....p.....p....h....h.......t...t.............h........p.........t........p............G.......h.............p.s..h...h........L....s..V.......s.h..A....h.H.o.s.......h.h....c.s........h....t............p...p......h.........t.....p......h.....l......t.......p.........l..............p.........h.............p.........s............s.......p...........l........s..........l......h....o....s...l..s...u.p.hh..............................ss.s.t.h.......t....p.h..h...h...c...p..lt...p...s.V...p....a....t...p....u.............l...........p..................th...................h..............t..............t..............G...................h...............p................h.................h..........l.................E...l..uP.t......s...L...t...t..hh.p...p......................................................................................................................h.........................................................................................................................................................................	0	1131	2658	3767
+1093	PF02273	Acyl_transf_2		Acyl transferase	Mian N, Bateman A	anon	Pfam-B_5787 (release 5.2)	Domain	This bacterial family of Acyl transferases (or myristoyl-acp-specific thioesterases) catalyse the first step in the bioluminescent fatty acid reductase system.	20.30	20.30	20.30	20.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.94	0.70	-5.40	4	59	2012-10-03 11:45:05	2003-04-07 12:59:11	10	4	39	2	8	132	21	269.20	60	83.59	CHANGED	hsIDHVIcVsssRcI+VWEThPKppssKRNNTIlIASGFARRMDHFAGLAEYLSpNGFHVIRYDSLpHVGLSSGpIDpFoMSlGKpSLLTVlDWLp.p+sIsNlGLIASSLSARIAY-llu-lsLSFLITAVGVVNLRsTLE+ALtaDYLph.IDElP-DLDFEGHpLGScVFVpDCFEssWDoLDSTINKhtpLslPFIAFTANsDDWVpQcEVhcLlSsI+Sc+sKIYSLlGSSHDLGENLVVLRNFYQSlTKAAIAhDsshl-lss-IIEPsFEpLTIATVNERRLKscIEs	...........................................sI-HVlplsssppI+VWET.PK...pp.sp+psT.IlI.A.S..G....FAR..R....M.D.....H......FAG......LAEYLSsNGF..HVlRYD..SL.pH..VGLS.S...Gs....IspFoM.S.l...G.K...p..SLhsVl-W.Lp...s+...G...l..p..p..lGLIAuS....L.S.A..R...I..A.Y.-...l.su.-.l..s.LSFL...IT..AV.GV.V.NL..RsTLE+ALtaDY...Lp.h.Is-lPpD.LDFE.GHpLGScV...FVpDCFcppW.DoL.-ST.ls...chppL.slPFIAFTANsDsWVcQcEVh-hlusIpSs+sKlYSLlGSSHDLGENLVVLRNFYQSVTKAAIALDss.l-lss-h......l..EPpFEpLTlsTVNERRLKscIEs...........................................................................................................................	0	2	4	5
+1094	PF00708	Acylphosphatase		Acylphosphatase	Bateman A	anon	Pfam-B_686 (release 2.1)	Domain	\N	20.80	20.80	20.80	21.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.99	0.72	-3.88	75	4748	2009-01-15 18:05:59	2003-04-07 12:59:11	13	31	3398	34	1333	3407	353	90.30	31	29.81	CHANGED	M...............hphplhlpG.pVQ..GVGFRhastphApphG.lpGa.VpNhs-G...pVclhspG.spps.lcphlptlpp..ussh.....uplpplph.pphshpsp........ssFpIt	.........................phphhlpG..+VQ..GV.G....F..R.h..h..shphApplu.....LsG.h....VpN...t.sDG.........pV-lh....s.p......G.sp.pp....lcph....l.p.t....Lcp....usss.......A+.V.splph...p...h.p.h..p..tt......ssFpI.......................................	0	404	800	1089
+1095	PF01553	Acyltransferase		Acyltransferase	Bateman A	anon	Pfam-B_128 (release 4.0) & Pfam-B_5069 (Release 7.5)	Family	This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [1].  This family also includes tafazzin Swiss:Q16635, the Barth syndrome gene [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.90	0.71	-4.71	57	17338	2012-10-02 00:16:30	2003-04-07 12:59:11	16	145	4819	2	5587	13699	5618	134.80	20	34.96	CHANGED	plplps....Epl.p..................ttssllluNHpSh...lDshhls.hhh...........pshhhlupcplhth.shhshhhp....hhsslhlcR.............................tp.pttttshpthhc...hlppG................ph.lhlFPEG.....Tcsps...................tph..h.aKpGshphshps.......sssllPlslp	..........................................................................................................h...h.s.....pp.l..p..................tts.h.l..l.l..u.N..H.pSh.............hD.h..l.h....l......s...hhh.......................................t..h.ph.h..u...c..p...p...l.....h......p......h...s.....h....h.....u.....h....h.hp.................hh.s..s.l.......l..c..R.................................................................................................................tt...t.t..s..t...t..s.h.cphhc.........hl.pp..u.....................................................................................ph...lhlF...P..E...G................o.+.sps.............................................................tph.......h.h.+.s.G..h.h..th..uhps......................sssllPlhh......................................................................................	0	1763	3288	4613
+1096	PF02805	Ada_Zn_binding		Metal binding domain of Ada	Bateman A	anon	Bateman A	Family	The Escherichia coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue. This domain contains four conserved cysteines that form a zinc binding site [1,2]. One of these cysteines is a methyl group acceptor. The methylated domain can then specifically bind to the ada box on a DNA duplex [2].	20.90	20.90	20.90	21.10	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.24	0.72	-4.38	150	1999	2009-01-15 18:05:59	2003-04-07 12:59:11	11	24	1681	5	495	1548	76	64.90	47	18.48	CHANGED	-ppap.AlhsRD..spaDGpFahuVpTTGIYCRPsCsuRhP+ccNVpFasouttApsAGaRPCpRC+P-	.....................................ppap.AlhsRD..sphDGpFhhAV+TTGIaCRPSC.s......u......R..t.......P..p...c......cNV....p...FassAspAhsAGFRPCKRCpP-.........	0	126	281	399
+1097	PF01602	Adaptin_N		Adaptin N terminal region	Bashton M, Bateman A	anon	Pfam-B_491 (release 4.0)	Family	This family consists of the N terminal region of various alpha,  beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles [1]. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family[2]; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles [2].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.50	0.70	-6.18	32	3862	2012-10-11 20:00:58	2003-04-07 12:59:11	15	87	445	26	2500	4196	107	460.30	19	58.89	CHANGED	cpphhpp-ltphhsph..............s.p....p+ppslpKllhlhhhGp...chs.....hhhhsll+hht.opchshK+lsYLhlh.hscppsD.....lhhL...sssslp+D.lp...ssNphhpuhALpsLuslt..sscls..csltsslpphls.spss..aVR+sAslshh+laph.....ss-hlpp....hsclpchl..sDps..........................hVhtsAlshltcl...................pssc.hh....cllthhhppltph....................s.sssahplhllchL.p....phstpsspts...........................................................................t.hhcplhshlp....................ssssuVlhEslpslh........plsspss........hhhhssshLhphLs.spcpsl+YluLps.lsplspp..........c.....pslh..cpshhlhhlp.csshsl+hcsl-lLhtlsscpNlpp...llpcLhpa......l....-ht-.p................a+pthlpsItplu.+h....ssshphhlssLlcllp.....ps..shh..sp-hl.slhpllpphsshpths..lppL....hchlps............hppsp.......h..htshlWllGEaushlss.................ssphlcplhpphh.pss.l+tt.hLsshhKht...........httst.pht.............plhphlhphsp..s.ch-lp-RAh..........hhpllptsp	................................................................................................................p.tt.hpp.....................p.t.....hptp.h.lt+.ll.................h.hh............h.h.G........s..hs..................h.h.phlp..hh.....t...s...pphp...K............+.l.......s...............YLhh..........hh..p.......p.p.-..............................hhhL..................ssssl.p.p......D..hp.........................s....s.....h....hp.uhA..lp..sl.s..p.lt...................ssp..hh............p..l....h...l..t.p.h..lt....s....t...s....s.......hV++p.A...sls..........h..h+l...hph.................................ss.p...h...h.......t.........hs.p....l..h..p.........hl......s-.ps..................................................................................hV.h.hs..u...l.sh...l...hpl........................p..sp...............phh....t...h...h.p.t.....l.th....................................................................................s.h.s...a.h.plh.l.l.c....h.l.t.............t.h.s...tp..ttt........................................................................................................................................................................................t.hhp..lhshlp.................................sts...tuV.l.h...pshps.lh......................................................ph..s.t..s.............................hhth.hs.s...Lhphl........p....sp..............p...p.............l.p....al...u...L..ps..lttl..h.tp............................p..............sl.........p..t...p...h........l......h...l....p...........ss..s.h.....l..+......h.t.....t..l....c.lhh.t....h...s........s...p.........p..N..l.pt..............l......l.p.....c..lh..p..a...................h............p.h...-.p.............................................htt..thl.pt..l.t...t..h..s..ph..............................s..sh.phh.......l.s.h.l.hp..l..l.p..............................ts.......s.hh.......hpph..h...l...h.p..l..h.........p.......p......................s........p.......h......p........t............h...............l.t...p....l..................h.p..h.l.pp.................................hp....p..............................h..htshh..a.llG.E..a.u....phh.p.................................................................................s.ph.h.p......h.....h....p..t.....h...h........p.....s................s..p..h.....hlsshhKhh.........................................................................................................................tlh....h.l..th.t........p.s.-.........lppRuh....h.tlh....t.............................................................................................................................................................................................................................................................................................................................................................	0	926	1396	2042
+1098	PF03352	Adenine_glyco		Methyladenine glycosylase	Finn RD	anon	Pfam-B_3953 (release 6.5)	Family	The DNA-3-methyladenine glycosylase I is constitutively expressed and is specific for the alkylated 3-methyladenine DNA. 	25.00	25.00	29.60	25.10	22.80	24.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.14	0.71	-4.75	190	3641	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	2986	18	794	2600	430	166.00	41	85.63	CHANGED	Ws....ss......slYhpYHDpEWGhP.lp.DDppLFEhLsLEGhQAGLSWhTIL+KR-saRpAFssFDsppV...Apa.....s.-pclccL.htssGIlRNRtKIcAsIsNA+shlplpc..ch.....GSFusalWsFV.sspP.hhsp..hpshtclP.....u..pTshScslSKcLKKRGF+FVGPThsYAFMQAsGhVN.DHlssChpptp	....................Ws..tps..slYhtYHDpEWGh...P..p...D.-.ptLFEhLsLEuhQAGLSWhTlL+K.....Rcsa....RpAFts.FD.p+V.......Ath........s.-p.-......l....-c.L..h.p.s.s..uIIRpRtKIpAslsNAp..uhlpl.....pp..........p.h...................G.SFssalWuF........l....st.ps...hsp...ht..s..hp..p..hP......................s..p..o..shS.ctlSKsLKK+GF+FVGsThsYuFhQA.....sGhVs.DHh.sC.hh..t............................................................	0	218	478	659
+1099	PF02438	Adeno_100	adeno_100; 	Late 100kD protein	Mian N, Bateman A	anon	Pfam-B_1583 (release 5.4)	Family	The late 100kD protein is a non-structural viral protein involved in the transport of hexon from the cytoplasm to the nucleus.	25.00	25.00	131.30	131.10	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	583	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.87	0.70	-6.30	19	136	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	100	0	0	144	0	588.50	65	76.54	CHANGED	ssLhKHlpRQutIl+puLp........-p.psPhoVsplSpthEptLFs......P+sPsc+pcNuos-PsPRLNFYPsFhlPEsLATYHIFFhNppIPlSC.+ANRotuDphhpLppusplsslsshccssKlh.-GLG.pEspusst.Lp........psutLVpLcsDssRLsslK.RshploaFAYPAlsLPPKl.pslh-pLlh+psp...........pps-sscPVVSDEpLs+Wls.ss.......-st..tLp......c+..RKthhuAlhhTlpLEChp+hFoc.phl+KlpEsLHYTF+HGaV+.spcIosVpLSNhVoYhGlhHENRLspssLHsoLcuEs+RDYlpDolYLFLlaTWQTAMGlWQQsL--cNlcplpclLs+p++sLasthspcslApcLAcllFPtc.LlpThppuLPDFhoQS.lpNFRoFILERSGILPuhssALPSDFVPlsa+EsPP.LWsHsYLLpLAsFLhhHuDhh......EDsuspslhcsaCcCNLCoPHRslspNsuLhNElpsIGTFElQsPsspsst......LKLTPuLWssAYL+KFsspDYasapItaYcspsc.s.pspLTACVITpscILApLppIpcuRE-FLL+KG+GVYLDPQTGEpLN	..DVLLKHLpRQShIl+DALt.......DRocsPlSVcELScAYEhsLFS......PRVPP...KRQsNGTCEPNPRLNFYPsFAVPEALATYHIFFKNQ+IPlSC.RANRoRADtlLsLtsG.uRlPDIsSLEEVPKIF.EGLGpDEsRAANA.Lppp...........ctppSsLVELEGDNARLAVLK..RolElTHFAYPAlNLPPKVMpslMDpLlhp+spsLsc......pptpps--ucPVVSDEpLuRWLG.Tp.......-Pp..sLE..........cR..RKLMhAsVLVTlELECh+RFFoDP-TLRKlEEoLHYTFRHGaVRQACKISNVELoNLVSYhGILHENRLGQsVLHoTL+GEARRDYlRDCVaLFLsaTWQTAMGVWQQCLE-pNLKELcKLLpRshKsLWTGFDERTVAuDLA-IlFPER.LppTL+sGLPDFhSQSMLpNFRoFILERSGILPATCsALPSDFVPLoYRECPPPLWSHCYLLpLANYLuYHSDlh......EDVSGEGLLECHCRCNLCoPHRSLsCNPpLLSETQlIGTFELQGPpssst..us.........LKLTPGLWTSAYLRKFlPEDYHsHEI+FYEDQ...Sc.P..+A-LTACVITQusILAQLpAIQKuRpEFLLKKG+GVYLDPQTGEpLN......	0	0	0	0
+1100	PF03052	Adeno_52K		Adenoviral protein L1 52/55-kDa	Mifsud W	anon	Pfam-B_2151 (release 6.4)	Family	The adenoviral protein L1 52/55-kDa is expressed in both the early and late stages of infection which suggests that it could play multiple roles in the viral life cycle.  The L1 52/55 kDa protein interacts with the viral IVa2 protein and is required for DNA packaging [2][3]. L1 53/55-kDa is required to mediate stable association between the viral DNA and empty capsid [2].	25.00	25.00	47.20	46.80	21.70	17.90	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.11	0.71	-5.09	18	154	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	99	0	0	150	0	187.10	52	54.87	CHANGED	lsp.ssuhAsct.......h.+.Qhcc-shcutlPppNlF...R-tpsp.....-t.RchhapuGptlphsh..cRsLpscDF....s-.s.....ulSsApsHhpAAcLtpsactTtphEsshpcoFsscl+sLlhR.ElslGLhaLhDFlpshhppPs.shsLssQLhLlspHscscsshRctlhslucsc......ucWLhDLlshltsIl.pccphsls-pVuAIs	...........htph.....GA.uPER.......HPRVQLp+DsRtAYVPtQNLF...RDcSGE...EsEEhRctRFcAGREL...R..L..DR..pRlLRsEDF..EssE.o......GlSPARAHluAAsLVoAYEQTV+pEpNFQKSFNNHVRTLlAREEVslGLMHLWDhhEAhlpNPs.SKsLTAQLFLlVQHSRDNEsFREALLNIuEPE......GRWLhDLINILQSIVVQERuLoLu-KVAAIN.........	0	0	0	0
+1101	PF02703	Adeno_E1A		Early E1A protein	Bashton M, Bateman A	anon	Pfam-B_1193 (release 5.5)	Family	This is a family of adenovirus early E1A proteins.  The E1A protein is  32 kDa it can however be cleaved to yield the 28 kDa protein.  The E1A protein is responsible for the transcriptional activation of the early genes with in the viral genome at the start of the infection process as  well as some cellular genes [1].	24.90	24.90	24.90	25.50	20.90	24.80	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.11	0.70	-4.95	15	313	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	91	4	0	292	0	158.20	37	97.87	CHANGED	MRplhhhssh.h....-hus-lLE...plVsshhss-hPp.ssshhpsPSLHDLYDLE..V-ssE.DsNEEAVsshFsDuhLLAAcEu......................sssh.ssppssGspslP-L.ps--hDLpCYE-GhPPSDsEDEpppp..shpphuspushshppt.......FhLDsPplPGHGC+SC-aHRpsTGssshhCuLCYhRspspFlYSPVSDst..--cosss.........................-pps.........SPPclssssP.slh.+PVPVRsostRRsAV-slED.......LLpE....ssEPLDLSl.KRPRs	....................................................................t.h....p....hlpthh..p..................s.oLp-LYDl-..Vps.p..DsNEcAVs.hFs-uhhLtsp.u........................s......s...s...hPtL.....hDLhCaEtshPsSDsEspp.....................................................................................hSt...........................................................................................................................................	0	0	0	0
+1102	PF01691	Adeno_E1B_19K		Adenovirus E1B 19K protein / small t-antigen	Bashton M, Bateman A	anon	Pfam-B_1569 (release 4.1)	Family	This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell [2]. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen [2]. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein [1].  The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis [2].	25.00	25.00	40.80	40.30	18.20	17.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.31	0.71	-4.87	17	117	2009-09-10 16:39:30	2003-04-07 12:59:11	11	2	86	0	0	102	0	134.60	47	75.49	CHANGED	M-....lhphLpsapphRpllctuSspsShhhRahFGupLuclVacsKp-acppFtclLs-s.GlasuLsLGapshappcllppLDFSoPGRssAulAFlsallDcWs.pcop...lSpsahLDhlshsLWcth...h.p...phhhh	........M-..lWslLpDFppTRpLlEsu..SsusShaWRah..FGos....Lu+LVaplKcDYppEFEclLs-CsGL.a-uLNLGHpuhFpE+ll+sLDFSoP..GRTsAuVAFlsFllDKWs.ppTp...lScGYhLDalAhtLWRsW..h+ppt...hph.....	0	0	0	0
+1103	PF01696	Adeno_E1B_55K		Adenovirus EB1 55K protein / large t-antigen	Bashton M, Bateman A	anon	Pfam-B_1728 (release 4.1)	Family	This family consists of adenovirus E1B 55K protein or large t-antigen. E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site [1].  This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the adenovirus E1A protein [1].  The E1B region of adenovirus encodes two proteins E1B 55K the large t-antigen as found in this family and E1B 19K Pfam:PF01691 the small t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.  This family shows distant similarities to the pectate lyase superfamily.	21.80	21.80	21.90	31.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.22	0.70	-6.00	15	139	2012-10-02 14:50:22	2003-04-07 12:59:11	12	2	88	0	0	132	1	334.00	51	78.03	CHANGED	sssshhsp....Lshuhhs+pR.EpVpap-lps-a..pct..hht-+YsFEQlKTahLpPt-.DhEtsI+paAKlALRPsspYpIp+slsI+ssCYIlGNGApVclsspcpsA.Fcsthh.uhsPGVsGMpuVTFhNlRFps-s..........asGslFhusTplllHGCsFhGFssoCl-uhussplRGCpFhuCa+ul.su+s+ucloVK+ClFE+CslGlhsEGpu+lR+Nsuo-ssCFlll+GsuplcHNhlsussch.pps.hpMlTCu..sGpspsLpolHIsSHsR+pWPsFc+NllhRCslHLGsRRGsFpPhQCNhoaopllLEscuhs+VsLsGlFDhshplaKlLRa.--s+sRsR.....sC-CGupHhph.ssshpVTE-lRsD+hhhSCsssEFsSS-E	......................s.pt.hscLshSLMsRpRPEplhatElpp-h..pct..hhppKYuhEQlKTaWLpPt-.DhE.AIcpaAKlALRPDppYplo+plsIRpsCYI.GNGApV.lss.D+sA..FcCsMh.sMhP...G..VhsMpuhsFhNh+Fpuct...............asGslFhusophhLHGCsFaGFNshCl............EsW.utsplRGCpF...........huCWhul.suRsKSphSV.KpClFE+ChLGl..s.EGpuRlR...Hsuu.-ss.CFhLlKGsAslKHNMlpGss-..pp..hphLTCs..sGhCphLtslHlsSHsR+tWPhFEpNllh+CphHLGuRRGhF.PaQCNhspsplLLEs-AhS.RVsLsGlFDMslplaKILRY..DEo..+sRsR.....sCECGG+HhRhpPVsl-VTE-LR.PDHLlhuCsssEFuSSsE...............	0	0	0	0
+1104	PF04623	Adeno_E1B_55K_N		Adenovirus E1B protein N-terminus	Kerrison ND, Bashton M, Bateman A	anon	DOMO:DM04583;	Family	This family constitutes the amino termini of E1B 55 kDa (Pfam:PF01696). E1B 55K binds p53 the tumour suppressor protein converting it from a transcriptional activator which responds to damaged DNA in to an unregulated repressor of genes with a p53 binding site [1]. This protects the virus against p53 induced host antiviral responses and prevents apoptosis as induced by the by the adenovirus E1A protein [1]. The role of the N terminus in the function of E1B is not known.	25.00	25.00	34.80	33.50	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.50	0.72	-3.49	5	123	2009-09-11 22:02:39	2003-04-07 12:59:11	7	3	65	0	0	110	0	68.70	40	17.64	CHANGED	MERsNPoEpGl+uGLHusAsVEuhptuAEEEsL+LLAuAASs.pssussssstAthtuGGus.uuuGGE..Es	...MEstsPspQGl+sGh+upu.VEshttuAsp-NLcLLAusAuh.ts...ss....puss.s.....t.uth...tuGuts..uuuGtp....t......................	0	0	0	0
+1105	PF04834	Adeno_E3_14_5		Early E3 14.5 kDa protein	Waterfield DI, Finn RD	anon	Pfam-B_4148 (release 7.6)	Family	The E3B 14.5 kDa was first identified in Human adenovirus type 5. It is an integral membrane protein oriented with its C terminus in the cytoplasm.  It functions to down-regulate the epidermal growth factor receptor and prevent tumour necrosis factor cytolysis.  It achieves this through the interaction with E3 10.4 kDa protein [1,2].	23.60	23.60	23.60	25.50	22.10	23.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.47	0.72	-3.57	8	110	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	68	0	0	79	0	104.20	50	79.38	CHANGED	pC+FpcPWsFLcCYpccoDhsssWlhhlshlhlhssThhultIYPphchGWNuPsAhshPphPs..tthPLQ........PhPpP............-P.PpsPosISYFpLTGGDD	......KCKFpc.WsFLcCYccKsDhPshalhIlGI.lhlhuCT.hFu.lhIY.PpFchGWNuspAhsaP.-Ps..tphP..........Phs.Pht..........pY.pEP.PphPoslSYFpLTGGDD.	0	0	0	0
+1106	PF03307	Adeno_E3_15_3		Adenovirus 15.3kD protein in E3 region	Mifsud W	anon	Pfam-B_3512 (release 6.5)	Family	\N	25.00	25.00	45.80	45.60	20.40	16.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.76	0.71	-4.35	8	100	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	71	0	0	67	0	116.40	64	88.98	CHANGED	DGphoEQRll..phR.tRppp-RpspELtsLhslHQCKKGlFCLVKQAKLoYE.lsu..psHcLuYpLstQRQoFssMVGssPIpVTQQuG-scGsI+CsCcsPEClYTLlKTLCGLR-LLP	..............DGpsSEQRll..QLR.lRQQQERssKELtDslsIHQCKKG.IFCLVKQAKIoYE..lsu..psHRLoYELPpQRQKFTCMVGlNPIVITQQSG-TcGCIHCSC-SPEClYoLlKT.LCGLRDLLP..........	0	0	0	0
+1107	PF02440	Adeno_E3_CR1		Adenovirus E3 region protein CR1	Bateman A	anon	Pfam-B_1854 (release 5.4)	Family	Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [1]. This region called CR1 (conserved region 1) [1] is found three times in Adenovirus type 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR1 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 80 amino acid region is unknown. This region is probably a divergent immunoglobulin domain (A. Bateman pers. observation).	20.00	20.00	20.20	20.30	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.17	0.72	-4.48	20	217	2012-10-03 02:52:13	2003-04-07 12:59:11	10	5	50	0	0	184	0	58.70	42	36.33	CHANGED	oVshGsNhTLlGP.ssspVoWY.....ssshpchCptsphc......hpaoCstQNLTLlNVopsasG	.....VshGsNhTLlG...P...sss...VT.Wa......ssphp.chCstsphc..........hpaoC..N.tQN..LTLlNVspsapG...	0	0	0	0
+1108	PF02439	Adeno_E3_CR2		Adenovirus E3 region protein CR2	Bateman A	anon	Pfam-B_1854 (release 5.4)	Family	Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [1]. This region called CR2 (conserved region 1) [1] is found in Adenovirus type 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR2 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 50 amino acid region is unknown.	26.20	26.20	26.20	26.70	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.01	0.72	-4.41	9	114	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	48	0	1	96	0	37.90	49	13.63	CHANGED	IPsShIuIIsAVllGhslIIlChhhYACCY+Kh+.p.Kh	.IPsoTlAIlsuVlsGhhllIIshhhYhCChK+.+.a.+....	0	1	1	1
+1109	PF03376	Adeno_E3B		Adenovirus E3B protein	Mifsud W	anon	Pfam-B_3736 (release 6.6)	Family	\N	25.00	25.00	27.60	27.60	20.60	18.50	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.33	0.72	-4.06	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	67	0	0	48	0	66.40	59	73.42	CHANGED	VuclsPDCLsPFssYLlFsFVTClslCSIlCllIsFhQhlDalaVRIAYhRHHPpYRNppVAsLLpL	...VuHAoPDCLGPFsoYLLFAhlTChCVCSIVClVITFhQhlDWhhVRhsYL+HpPcYRspsVAtLLRL.......	0	0	0	0
+1110	PF04528	Adeno_E4_34		Adenovirus early E4 34 kDa protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4904 (release 7.5)	Family	Conserved region found in the Adenovirus E4 34 kDa protein.	25.00	25.00	49.30	48.70	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.97	0.71	-4.61	17	117	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	86	0	0	105	1	147.40	57	51.52	CHANGED	Ltshh+phlhGshhNpcahWYRchVNpthPcElhYVGSVahRGtHLIYl+l.....haDuchhsllcphs...aGhshhshGlhsshlVLsCppCs.shoEhphRsCA+RTRplhh+slpllsppsh...............ppStsEccRQ+hL+tLhpap+slhh	..........................LAsWFR+lIhGsMhNQRhPWYRplVNh.pMPKEIMYhGSVFhRGRHLIYl+I.....WYDGHsGuIlssMS.....FGWSshN...YGLLNNhVIhCCTYCp.sLSEIRMRCCA+RTR+LML+AltIlsc-TssscP..........lsSSRTE.RRQRLLRuLMc+pRPI..h................................	0	0	0	0
+1111	PF00541	Adeno_knob	adeno_fiber; 	Adenoviral fibre protein (knob domain)	Bateman A	anon	SCOP	Domain	Specific  attachment of adenovirus is achieved through interactions  between host-cell receptors and the adenovirus fibre protein and is  mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.	25.00	25.00	65.80	65.70	17.40	16.80	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.40	0.71	-4.61	46	374	2012-10-01 20:11:45	2003-04-07 12:59:11	12	13	129	144	0	334	1	176.00	40	50.73	CHANGED	LWTTPDP.SPNCpl...pp-pDuKLTLsLTK.CGSQlLuoVSLlsV.pGp.hpslssshp......shslpLhFDssGsLhs........sSslspsYWNa.................................RsssSss..ussapNAls...........................FMPNhsAYP+...........sppspu+spIhuplYLpGp...shpPlslploaNppsss.......sYSloFsashsps..Yt...s..sFsooShTFSY	....LWTTPDP.SPNCpI......ppspDuKLTLlLTK.sGuplhusVSLlsV..sGphphlsssps.....hshslcLhFDssGsLLs........sssh..KshWsa.................................Rss..sohs..ssshpsAlu...........................FMPshsAY.Pp...........spppps.cshlhussYhtup...stpPlslplshNpcsss.......sYSIoFsauhsps..ht.....s.hsF.sTosaTFSY...	0	0	0	0
+1112	PF00608	Adeno_shaft	adeno_fiber2; 	Adenoviral fibre protein (repeat/shaft region)	Bateman A	anon	Bateman A	Repeat	There is no separation between signal and noise. Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, rather than the 'shaft' region represented by this family. The alignment of this family contains two copies of a fifteen residue repeat found in the 'shaft' region of adenoviral fibre proteins.	20.50	20.50	20.60	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.35	0.73	-7.21	0.73	-4.10	63	1159	2009-01-15 18:05:59	2003-04-07 12:59:11	12	20	137	15	1	857	6	30.00	30	24.56	CHANGED	sssLslshussLslss.ssLslplussLshs	...sssLoLshusPLslss.ssLsLpluusLsl...............	0	0	0	0
+1113	PF04881	Adeno_GP19K		Adenovirus GP19K	Kerrison ND	anon	Pfam-B_6142 (release 7.6)	Family	This 19 kDa glycoprotein binds the major histocompatibility (MHC) class I antigens in the endoplasmic reticulum (ER).  The ER retention signal at the C-terminus of GP19K causes retention of the complex in the ER, preventing lysis of the cell by cytotoxic T lymphocytes [1].	20.00	20.00	22.00	83.50	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.00	0.71	-4.43	6	78	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	49	0	0	58	1	133.40	56	81.67	CHANGED	CsLTFAs-ssc.CsVLIKCua-Ccsl.cIpapNKThspol.sssWpPGs.sp.YTVoV.............pGsDGo.hhsNsT....FIF.spMC..........DlsMaMS+QYsLWPP.oKENIVsFSlAaslsACllouLlslslthhlph+PRpuN.EKEKhP	...CslThus-pSc.CsVlIKCta-C.h..pITaKNKThsNsh.susWcPGD..p.YTVoV.............+GsDG.....NpT....FIF.phMC..........Dlshahu+.auLWPP.oK-NhVsFSlAaslhAClhouLLssslhhhlpp+PR.uN.EKEKh..........	2	0	0	0
+1114	PF01065	Adeno_hexon		Hexon, adenovirus major coat protein, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_885 (release 3.0)	Domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX.  The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	18.60	18.60	20.00	20.00	17.90	17.80	hmmbuild  -o /dev/null HMM SEED	495	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-12.75	0.70	-5.64	36	2918	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	287	43	0	1583	0	236.80	39	78.17	CHANGED	FRNPTVAPTH-VTT-R.SQRLQLRFVPVppEDspYoY.KsRFoLuVGDNRVLDMuSTYFDIRGsLDRGPSFKPYSGTAYNsLAPKuAsNNs.ap.................ssss.................spshAQAshhs...................sspsst.ttspthhsssshpPpPQlG..tss...Ws...tspsstptuuGRlL.....csssshhP......CYGSYApPTN.pGuQu................s.slpphaassssssss.........ssslhhsEsVs..LpsPDTHlVhh..ssss..sups.hs..uhPNRPNYIGFRDNFIGLMYYNSsGNhGVLAGQuSQLNuVVD.LQDRNTELSYQhhLssLsDRsRYFShWNQAVDSYDs-VRlI-NcGhED-hPsYsFPlsGlss..tsasslptsss.....tsapsssssssss.....hluhGNlsuMEINLsANLaRsFLYSNVAhYLPDchKaT...PsNls........LP.sNsNTYsYMNuRlPsssllDoalNIGARWSlDsMDNVNPFNHHRNsGL+YRSQLLGNGRYspFHIQVPQKFFAIKNLLLLPG	.................................................................................................................................................................................................u.hs.........................................................t..t.h.t.....Ppsp.G.....tt.....................huRhh.....c..t............................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1115	PF03678	Adeno_hexon_C		Hexon, adenovirus major coat protein, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_885 (release 3.0)	Domain	Hexon is the major coat protein from adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together by 12 copies of polypeptide IX.  The penton complex, formed by the peripentonal hexons and base hexon (holding in place a fibre), lie at each of the 12 vertices [1]. The N and C-terminal domains adopt the same PNGase F-like fold although they are significantly different in length.	21.40	21.40	21.60	22.10	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.60	0.70	-4.90	23	736	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	213	43	0	552	0	193.00	81	34.68	CHANGED	NsTNDQoFsDYLuAsNhLYsIPAssTslsIsIPuRsWuAFRGWSFTRlKspETPslGusaDP.FpYSGoIPYLDGTFYLoHTF++VSIpFDSSVsWPGNDRLLoPN.FEIKRs..lD...uEGYshuQSNhTKDWFLVQMhANYNhGYQGY+lPssh+.hpYuFl+NFpPMoRQlPshsp.st.achlshs.p...............aNNSGahuhps....shtt+pGHsYPANWPYPLIGpsAlts..lTp	........NDTNDQSFNDYLSAANMLYPIPANATNVPISIPSRNWAAFRGWSFTRLKTKETPSLGSGFDPYFsYSGSIPYLDGTFYLNHTFKKVSIMF.DSSVSWPGNDRLL..TPNEFEIKRo..VD...GEGYNVAQCNMTKDWFLVQMLupYNI..GYQGFal..PEuYKDRMYSFFRNFQPMSRQVVDphpYpc.YptVslsaQ...............HNNSGahu.hu......s.ppGpsYPANaPYPLIGtpAl.s.....hp.......	0	0	0	0
+1116	PF02456	Adeno_IVa2		Adenovirus IVa2 protein	Bateman A	anon	Pfam-B_1982 (release 5.4)	Family	IVa2 protein can interact with the adenoviral packaging signal and that this interaction involves DNA sequences that have previously been demonstrated to be required for packaging [1]. During the course of lytic infection, the adenovirus major late promoter (MLP) is induced to high levels after replication of viral DNA has started. IVa2 is a transcriptional activator of the major late promoter [2]. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.18	0.70	-5.81	11	128	2012-10-05 12:31:08	2003-04-07 12:59:11	10	1	98	0	0	181	10	359.20	69	84.98	CHANGED	lDpp.ht.lp-hac+ltshppslpshshu.h.....tPh....ppFsSa-chhuhuG..llpcLpcsppplccthstsphaLpssGphsSLNhshQPlIull....YGPTGsGKSQLLRNLlSspLIsPsPETVhFIsPphsMIPPpEhsAWchQlsEGNYssss-GTlsPpouTh+PcFlcMoY--hTss-NhDlscPpNlFspAAppGPlAIIMDECM-cLssp+uIShhFHAhPSKLasRaspCTGaoVFVVLHNMNPRpshuGNIssLKIQAKlHIlSs+hpP.QlsRFlpoYo+uhspsl.slLLKsIFsahpppspYsWllYNssP.pEuhpWs.hLcsppulhPhhLNlQshlacslc+Ip+hh....p-RpRappth+pKhp	..........................................LDRDAlE+lTELWDRLpLLpQTLscMPMADGL....KPL.KNFuSLpELLSLGG-....RLLs-LVRENhpVRcMhNEVAPLLR-.DGS.C..SL...N...Yp.L.Q.P.V.IGVI....YGPTGCGKSQLLRNLLS.uQLIoPAPETVFFIAPQVDMIPPSEhKAWEMQI..CEGNYAPGPEGTllPQSGTLRP+FlKMuYDDLTpEHNYDVSDPRNVFApAAA+GPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDLGGNIANLKIQAKhHIISPRMHPSQLNRFlNTYTKGLPlAI.SLLLKDIhpHHAQ+PCYDWIIYNTTPEHEAhQWs.YLHPRDGLMPMYLNIQoHLYRVLEKIHRsL....NDR-RWoRAYRARps.........................................................................................	0	0	0	0
+1117	PF01686	Adeno_Penton_B		Adenovirus penton base protein	Bashton M, Bateman A	anon	Pfam-B_1180 (release 4.1)	Family	This family consists of various adenovirus penton base proteins, from both the Mastadenoviradae having mammalian hosts and the Aviadenoviradae having avian hosts. The penton base is a major structural protein forming part of the penton which consists of a base and a fibre, the pentons hold a morphologically prominent position at the vertex capsomer in the adenovirus particle [1]. In mammalian adenovirus there is only one tail on each base where as in avian adenovirus there are two [1].	25.00	25.00	94.70	94.50	15.40	15.00	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.49	0.70	-6.25	19	217	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	130	39	0	205	0	436.00	67	95.37	CHANGED	h-..hsPPRhhAPTEGRNSI+YopLsPL.DTTKlYhlDNKouDIsoLNaQNDHSNFhToVlQNsDhoPtEASTQoIpLD-RSRWGG-LKTlL+TNhPNVscFh.SNoh+s+lMss................ctssssspYEWh-lolPEGNao.stlIDLhNNAIl-pYLtlGRQpGVhcSDIGVKFDTRNFpLGhDPlTsLVhPGhYT.cAFHPDIVLLPGCuVDFTaSRLsNlLGIRKRpPYpcGFhIhYEDLpGGNIPALLDlpsYpts....................................................................................IpP.lhpDSpuRSYpVhpssos.....TtYRSWhLAY.N........spsuspspTLLTsPDlTsGltQlYWSLPDhhpsPlTF+ss.ppssshPVVGhcLhPlhu+shYNspAVYoQllcptTs.tTpVFNRFPENpILhpPPhsTlTslSENVPuloDHGTLPL+NSlsGVQRVTlTDsRRRsCPYVYKSLusVsP+VLSSpTh	............h.-s.hVPPRYhuPT-GRNSIRYS-LsP.aDTT+lYLVDNKSuDIsoLNYQNDHSNFLTTVlQNNDFTPsEASTQTINFDERSRWGGDLKTILHTNMPNVNEaMFTsKFKARVMVuR+.s..........tsDtupchLcY-WaEFTLPEGNFSETMTIDLMNNAIl-NYLpVGRQNGVLESDIGVKFDoRNF+LGWDPVTKLVMPGVYTYEAFHPDlVLLPGCGVDFTcSRLSNLLGIRK+QPFQEGF+IMYEDLEGGNIPALLDVcpY.cScpchtptttts...t.......................................................t.httt..tsstcclsIpP.lpcDspsRSYNVlpssp.......sThYRSWYLuYsYG..................DPEKGVpSWTLLTTPDVTCGuEQVYWSLPDhhpsPVTF+so.ppsssaPVVGsELhPh.huKSFYNt.AVYSQhlcp.Ts.hT+VFNRFP-NpILhRPPssTlToVSENVPAloDHGTLPL+sSltGVQ...RVTlTDsRRRTCPYVYKuLuhVsP+VLSS+Th.	0	0	0	0
+1118	PF03955	Adeno_PIX		Adenovirus hexon-associated protein (IX)	Finn RD	anon	DOMO:DM01967;	Family	Hexon (PF01065) is the major coat protein from  adenovirus type 2. Hexon forms a homo-trimer.  The 240 copies of the hexon trimer are organised so that 12 lie on each of the 20 facets. The central 9 hexons in a facet are cemented together  by 12 copies of polypeptide IX.	21.80	21.80	23.30	42.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.58	0.72	-3.53	12	121	2009-09-10 22:51:00	2003-04-07 12:59:11	9	1	96	4	0	85	0	109.30	59	79.56	CHANGED	-GtlhosaLTsRLPsWAGVRQNVhGSslsGtPV.hPuNStshphtphs..ushcssAAAsu..ptutssspshstsht.hstlt.ph.u........pctLthllspLcpLpppLtth	.EGGlFSPYLToRLPuWAGVRQNVMGSTVDGRPV.hPANSST.hTYATVG.uSoLDosAAAAA..uAAA.TAptlAushh..us.ussssSS.....ltE-KLhsLLAcLEALoppLus.L.....................	0	0	0	0
+1119	PF03910	Adeno_PV		Adenovirus minor core protein PV	Finn RD	anon	DOMO:DM04810;	Family	\N	20.30	20.30	30.70	24.40	17.50	16.80	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.56	0.70	-5.37	12	112	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	88	0	0	111	0	325.30	60	96.48	CHANGED	MSKRKhKEEhLpslAPEIYGP..s.hpsch..KPRplK+V........KKcc+..tc-..........p......-stVEFVRpFAPRRRVQW+GR+VpRVLRPGTsVVFTPGERSshp..KRsYDEVYuD-DILEQAApphGEFAYGKRuR..............-.lulsLDpuNPTPSLKPVThQQVLPs.s......+RGlKRp.ttcl.PThQlhVPKRp+lE-VL-phKs............................................................-PslpPEVKV..RPIKpVAPGLGVQTVDIpIPs............-s............M-sp....sc.P.s.s.................................hsshpl....QTDPWh.hs..........ssppp+ppR+YGsAstlhPpYsLHPSIh........PT.............PGYRGpp.apsphptssRRRpssspRp+p........hsPstlhRshsRRG+..pls	.......................................MSKRKhKEEMLQVlAPEIYGP...s..ts-p...KPRKlKRV................KK+c..c...tt................s........-stVEFVRpFAPRRRVQWKGR+VpRVLRPGTsVVFTPGERSusp..KRsYDEVYGD-DIL-QAA-RhGEFAYGKRuR.............p-hlulPLDcuNPTPSLKPVTLQQVLPsss....pRGlKRE..upslhPTMQlMVPKRpRlEDVL.-p.hKh.......................................................D.tlpPE.VKV..RPIKQVAPGLGVQTVDIQIPs...................s.....................M-sppc.P...................................................................ooohEV....QTDPWhsssss............sssp.pRRR+.aGsA.StL....hPsYsLHPSIl...............PT.............PGYRGop.Yt...sRp.psup+RRppsspRRR.........lsPu.tVpRVshRcGR..hlh................	0	0	0	0
+1120	PF01310	Adeno_PVIII		Adenovirus hexon associated protein, protein VIII	Finn RD, Bateman A	anon	Pfam-B_1405 (release 3.0)	Family	See Pfam:PF01065. This family represents Hexon.	25.00	25.00	49.30	40.90	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.58	0.70	-4.53	17	163	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	109	4	0	124	0	206.60	56	98.48	CHANGED	cphPTPYlWpYQPptGhsAGAuQDYoo+hNWl........sAGPpMhs+lpslpspRNpllhppAthspsPhss.N.ssWPAs.lhp.sss...Ppslhhs+spsh-pth.........TsuGhQLAGGut................................hthpG.hQLss........P.sttth..RPsthh..QLuGuuh......hs..ppshhhhppusS..lPRoGGluspQFlcEFsPsVY.pPF.SGsPssaPcpF.s.Ycssssshcuas	.............................................K-IPTPYMWSYQPQhGlAAGAuQDYSo+MNWL........SAGPpM..ISRVNslRsp.RNpILLcQAAlTsTPRspLNP.sWPusLVYQEhPs...PTTVlLPRDAtAEVpM..........TNuGsQLAGGuphs.hts.......................................ttuIKpLhIRGRG.hQLNDEh.............VSSuhGL..RPDGlF..QLuGuGR....SSFTP.pQAhLTLpoSSS..pPRSGGIGTlQFVEEFlPSV.YFNPF.SGSPGpYPDpFIPNFDAls-uVDGYD.....................	0	0	0	0
+1121	PF02459	Adeno_terminal		Adenoviral DNA terminal protein	Bateman A	anon	Pfam-B_1602 (release 5.4)	Family	This protein is covalently attached to the terminii of replicating DNA in vivo [1].	20.60	20.60	21.20	243.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	548	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-12.75	0.70	-6.34	17	138	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	99	0	0	157	3	552.20	65	87.77	CHANGED	MLhsLuPpsPsTtphPhhthPPPHLLlGYQYlhRshNDYlFDsRsYSpLpYpphhp.t...pplsWoshssCSYoINTGuYpRFl.Dh-....NFp-TlsplQpAlLh-RllADLulht...hRGhGhs.h......tttpls.......ptl.pcphpplsthpspuhGhupchRlp..........pAup+DhslLssIR+L+sAhhpFLlspth..........tstcshLsLP.....s-s.sWLsuFlccFuc....php............tphsspphh+sllosLoLsps..........tusshsGGsFp...........LRPRE.sGRAVTEo.MRRpRGchlcRFlDRLPlppRRRRh..ssP.P..s.ptt.tttth....-Ep.p.............tFt-EVhsolsEsIchLp-ELTssARpppFFsFAscFYcll.chcsh..uclsEthLRRWlhYFFlsEHIAoTL.YLappLphpt.FtRaVplphsQVlhRuRDtsGp.laoRVWsEpupsA..FppLhpRIhpDlhshlERAGct-..hpp-Eh-pFhs-Isap-sSGDlpEIL+QlslN-s-IDSl-lSFRhKhoG.VsaSspcpIps.sRRVlptA..LRppc.ps	..................MLEDLAPGAPATpRWPLYRpPPPHFLVGYQYLVRTCNDYlFDoRAYSRL+YoEllpPG..hQTVNWSlMANCoYTINTGAYHRFV..DhD....DFQsTLTQlQQAILAERVVADLALlQP..hRGaGlTRM......tt-ppls.........................lERLMpDYYKsLuRCQspAWGMA-RLRIQ..........QAGPKDlVLLATIRRLKsAYFNaIlSshsu......................ppst.tpTsLSLP...............CDC.DWLDAFlERFSDP..VDLpsl.........................htssPTtQLI+CIVSALSLPNG.s................s...phpchpGGVFp...........LRPRE.sGRAVTET.MRRRRGEhIERFlDRLPVRRRRRRs...PPP....Ps......sP.E..pt...........t.E..............hh.......E.......EEEEEt......................................ssFEREVRsTlAELIRLLE-ELTVSAR..NuQFFNFAVDFYEAMERLEAl..GDloEhsLRRWIMYFFVsEHIATTLNYLFQRLRNYAVFsRHVELNLAQVVMRARDs-GsVVYSRVWNEsGhsA..FSQLMuRISNDLAATVERAGRGD..LQEEEIEQFMuEIAYQDNSGDVQEILRQAAVNDsEIDSVELSFRFKlTGPVsFTQRRQIQDlNRRVVAHAStLRAQ+p.........	0	0	0	0
+1122	PF03228	Adeno_VII		Adenoviral core protein VII	Bateman A	anon	Pfam-B_3049 (release 6.5)	Family	The function of this protein is unknown. It has a conserved amino terminus of 50 residues followed by a positively charged tail, suggesting it may interact with nucleic acid. The major core protein of the adenovirus, protein VII, was found to be associated with viral DNA throughout infection. The precursor to protein VII were shown to be in vivo and in vitro acceptors of ADP-ribose. The ADP-ribosylated core proteins were assembled into mature virus particles. ADP-ribosylation of adenovirus core proteins may have a role in virus decapsidation.	21.20	21.20	23.80	23.80	20.80	18.30	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.78	0.71	-3.51	14	129	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	102	0	0	107	0	116.10	57	66.84	CHANGED	MuILISPSNNTGWG.LGs.ppMaGGA++hScpHPV+VRsHaRAsWGuhp....GRssh..h..th....t.hp...ssthssTsDsVhcs...lsAsuRtht+p+RRhc....h.sRR+thttsotAhRt........ARu	..MSILISPSNNTGWG..Lss.....Sp.....MY.....GGA++RSsQHPVRVRGHaRAP..WGAhKtt..........ttsRTT..VDDVIDpV..VADARNYT...s..ssSTVDuVIDS...VVADARsYARRKpRpR....RhARR+ps...TsAMRAAR.Alh...................................................................	0	0	0	0
+1123	PF04439	Adenyl_transf		Streptomycin adenylyltransferase	Kerrison ND	anon	DOMO:DM04121;	Family	Also known as Aminoglycoside 6- adenylyltransferase (EC:2.7.7.-), this protein confers resistance to aminoglycoside antibiotics.	20.60	20.60	20.60	20.90	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.90	0.70	-5.40	6	625	2012-10-02 22:47:23	2003-04-07 12:59:11	7	5	514	1	75	442	9	256.10	36	96.18	CHANGED	MRoEpEMhDllLchA.pcEclRlVsLpGSRTNpNlsKDcFQDYDIsYhVoDl-sFIp-csWLppFGchIhhQcPEDh-h...Fss-hsptauYlMLF-DGNKlDLTLhshc-hpcah.......-sDsLhKlLlDKDshl.p.lsPsDppYalK+Pop+EFpcCCNEFWhVosYVsKGlsRcEIlaAhDHhppIlRsE.LL+MluWaIu.p+GaplShGKNhKahc+YLsschWpch.uTashsuYcchWpSLFhsppLF+phupcVupthsYsYP.-h-.csIpcYhcshhpp	......................................MRoEpEhhplllphA.p-c+IRsVhhpGSRsNs.......ps.+DpFQDY..DIsYhV..p..-..hp...s.a...hpst........s........WlppF.Gp.h.lhhQpPcc.hph.......hs...s..p....p...p...t..hsYL..MhF.p.D.G.s+IDLTLhPlcplcpah..................................pt......Ds.....LhplLlDKDshh.....t....s.s..o..-.psY.hl.pp...P..op.p-Fp.csCNEF.WasosYVsKGLhRcElhaAhshhpths+pp.Ll+hls.Wpl.uh.cpsa.p.l.s.lGKphKalppY.l.st-h..hcphhpoashssh-phWpuLhhhtpLF+phupclA.pp..htapYs.phs.cpltpYhpph...h.........................................................	2	29	51	60
+1124	PF01928	CYTH	Adenylate_cyc_2; 	CYTH domain	Aravind L	anon	Aravind L	Domain	These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate.  Six distinct non-homologous classes of AC have been identified.  The structure of three classes of adenylyl cyclases have been solved [3].	23.10	23.10	23.10	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.36	0.71	-4.61	51	3690	2012-10-01 23:11:28	2003-04-07 12:59:11	16	10	3229	34	930	2667	248	182.60	21	64.24	CHANGED	hhElEhKhhl....t..t......htphpspthshhpppshYasss.....shphttpp.tsLRlR............................sptth.lThKsst..t......phpsths..........................h.t..hhtlhsths.....................hp.h..sslpppRptapl....tt........stlslDtschl............hs.hElEhpspstpph.phhcp...........t..t.hth.thsthtRsYhphhtt	...............................................hEIEhKhhls.........tthpt.l...............htph.....t.....h.p....t.t...s.....h.....p......t.sh....Y.a.-Ts........c....L...t.t.p...c...huL...RlR...........................h.....s..st....th...hTlKs..ss.......................hsshhp..t....Eh.ph.ls...................................................hst..hht.h.htths.........................lp.s..l...hs..hshh.R....pphhl...............st...................hplslD....p....schh..........................sh.s...-hEL..El....p..s...s..s....h....p...t....h..h..p.hhpp..........h.......t....h......ts.....schtRhh..h...st.....................................................................	0	244	546	742
+1125	PF01295	Adenylate_cycl	Adenylate_cycla; 	Adenylate cyclase, class-I	Finn RD, Bateman A	anon	Prosite	Family	\N	21.80	21.80	25.30	25.30	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	605	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.99	0.70	-6.25	18	1028	2009-10-20 15:17:26	2003-04-07 12:59:11	13	6	915	0	113	599	28	520.90	64	68.95	CHANGED	-WlDhGGhuplsApEYFGASLWQLYKGIDoPYKuVLKhLLLEAYStEYPNTcLluhphKp+hh........sschs.paphDsYhhMLE+VTpYLpplsDhpRLDhlRRCFYLKssEslu...p..tsssWRpphLscLlspWsWocpplppLDpRpsWKIcpVcps+spLl-tLMtSYRNLIpFAR+pplssSIsPpDIuILoRKLYuAFEsLPGKVsLlNPpIS.sLSEssLTFIpVpp.s+t...psGWYLhNQuPcstthsspphlEasc.LsKLVAWuYFNGLlTspTpLHlhspsscl..spLppFlsDL+toFPlp.sspsospsLppPCEIRpLslhlNLppDPTp+h..pslchchpsoDlFSFGpppcsLVGSIDllYRNsWNElRTLHFcGspAlLcALKsl.sKhHpsussPcSlcVFCYSp+hRuplcshVtsLlpcCIplpLus..ppptpphpsL+luGcsatlFFEc+GlSlQcLpsshsh..............aspIoppKht..sh...ttppppphPt.IDuFASEGhlQFFFEssc..puFNVYILDEsNclElYppCsGsK--hl+clN+hYsssp.cptpsstphl..NFNhPQFYpllps......sstlpllPFpuptptp	........................................EWLDLGGLSoLSAEEYFGASLWQLYKSIDSPYKAVLKT.LLLEAY........SW....E.YPNs.+LLAcDlKQRLa........sGEls...saGLDPYshMLERVTcYLstIp..D....TRL.DLVRRCFYLKVsEKLS....p.p.p.u.ssuWRRtlL.spLVpEWsWsc.sp.LshLDNRusW.KI-QV+csHscLLDAhMQSYRNLI+.FA...R.RN..slos.S.hSP...QDIGlLoRKLYA.AFEsLPGKVTLlNPQISPDLSEssLTF..I..VPs...G..Rs.....N+sG...WYLY..N..puP...........shc..sI..l.u.a..pPLEYNRYLsKLVAWAaFNGLLT.upT+Lal+ussh.s...sKLpchVuDl.pppF.P.LR....ls.sPT..sc...A.....LhoPCEI.RcLAllVNLEhDP.Tutapsp.sl+hDh+clDlFS.FGppQpCLVGSlDLlYRNSWNEVRTLHF.sGEpuhl-ALK.TlL.....G.KMHQDA...s...P.P..-.SV-VFCYSp+LRGlIRsRVpQLVuECI-LRLus..pppcssRFKALRVuGQsWGLFF.ERhs.VSVQKLENul-F.........Ysu.ISp.NKL+.Ghslpl....cssps+.....L.P..sVVDuFA.SE.......GlIQFFFE....-o....t..p.p.GFNIYILDEuNRlEVYHcC-GoK-ELV+-VsRFYoSu+..Dc.s.hu..ushI....NFN.LP.QFYQIVps......-G..ctpVlPFRsp...p.h..........................................................................................................................	0	16	40	81
+1126	PF00709	Adenylsucc_synt		Adenylosuccinate synthetase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_690 (release 2.1)	Domain	\N	19.90	19.90	21.30	20.20	19.00	19.70	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.50	0.70	-5.82	92	5395	2012-10-05 12:31:08	2003-04-07 12:59:11	16	13	4698	55	1514	3933	4438	387.40	46	96.96	CHANGED	sslllGsQWGDEGKGKlVDhLu.......pcsDhVVRapGGsNAGHTlVss....s.c+atLHLlP..SGllpsss.hslIG.NGVVlcP.sLlc.Elcp.Lp.ppG.lsh..scLhISccAHllhPaHptlDthpE....t..pupt....pIGTTt+GIGPsYpDKsuRp.G.lRlsDL..h.c......chhpc+Lcph..........lp.p.Nthh.ppha.........t....p.h.shcplhpchhphsc............................................plp....sh..ls.Dsshhlpculcp.sKplLaEGAQGshL.DlDaGTYPaVTSSsssuuGsssGsGluPppls..pVlGVsKAY.oTRVGsGPFPTE..lh........s-......hG-plp.............ct..............................................G...p....EaGsTTGRsRRsGWhDhVhl+Yus.plNG.hsslslTKLDVL....sshcclKlCsuYch....sGc....................hlc.thPss.httlpcscPlYEphsGW.p....pchssscp..a--LPtsAppYlctlEchl.uls...............lshlSsGPc.RcphIh	....................................................................................................................................................................................s.lVVlGsQW.GDEGKGKIsDh..Ls................ppuchVsRa.Q...GGpNA..GHT..lVl................s............G..pcahLHL.lP..S.GIh.pts......h....hslIG........NGV..VlsPtsLhc..Elpt...Lc..p..p.......G.......lss..........ppLhI...ScpA...p...............l...IhPYHhtlDphpE................pt..+Gsp.........pIGTTt+GI.......GPu.Y.....t.....DKs.....u.............Rh...G.....lRluDL................h..-t.....-thtc+Lcps...............lph+..Nhhh...pha.......................................tt.......psl...sh.cclh..c...c.hh..t...hu.c............................................tlp.....sh...ls..DsshhLs.......p.Ah..........c.p....G...c.plLFEGAQG.............shL..DID.a.........GT.Y.P....aVTSSNssAG.Gs...ss.G.u.G.lGPptls....pVlGlsKAY.oTRV......G.........s......G..PF..PTE..Lh...DE...........................hG-.tlp..............ch..............................................................G....p....E.........a.Gs.TTGR.R..RsGWhD...sVslRhuh.p.......l......sG.l......os..lsLTKLDVL........s..Gl.c...plKlCluYch........-Gc.......................pls...hP..hs...hpth..ppscPlYEphP.GW...p....Eshtus+s.....hc-.........LP.psAppYlc..................RlEEls.Gl............................lshlSsGPcRppTh...........................................................	0	480	920	1248
+1127	PF00106	adh_short		short chain dehydrogenase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family contains a wide variety of dehydrogenases.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.81	0.71	-4.33	230	80936	2012-10-10 17:06:42	2003-04-07 12:59:11	20	600	6093	916	30667	110825	42278	163.30	25	56.70	CHANGED	GTlLlTGGoGuLGttlARaLspp.Gsc+LlLsSRp.............u.tusuuscL.....hs-Lp...thG..ApVplsu.sD...luDc.sslssllssls...t.tPlsuVlHsAGl...lc..Duslssh.....os-chs..pVhpsK....ssuAhpLcclstc....hs......LstFVlaSSsAulhGusGQusYAAANuaLDuLAcpR+upGL	...................................................................................ssll...T...G......u.........u.....p.........G.....I......G....t........u.......h.............A...........p.....t.......h....u........p........p.....u............u......................h.........l.........l....h...s....s.ps..............................................pt..h.pph....................hp.p.lp.............t....G......s........p.........s.........h..........s................h..........t......h..........D.................l....s......s........t.......p...........s.......l.........p..............p.........h.......h........p......p............h...........h...........t............p..........h..........G..........p............l.................D.............l.....L..........l...........N.....N.......A.........G....l.....................tt...............s........s.......h......t......c.h..........................s....c....p.......a....c............p...h.....h..........s..l..N.................l.h...u....s....h....h....h..s....p....t.hhshh.................................htps........tG.p..I..l..s..l........u...........S............h............s............u............h............h.............s..............................s............t..............................s............s............Y..........s.......A....o..K....tu....l..h.u.hscslsh-..t......................................................................................................	2	8711	17860	25336
+1128	PF04619	Adhesin_Dr		Dr-family adhesin	Kerrison ND	anon	DOMO:DM04566;	Family	This family of adhesins bind to the Dr blood group antigen component of decay-accelerating factor.  This mediates adherence of uropathogenic Escherichia coli to the urinary tract.  This family contains both fimbriated and afimbriated adherence structures [1].  This protein also confers the phenotype of mannose-resistant hemagglutination, which can be inhibited by chloramphenicol.  The N terminal portion of the protein is though to be responsible for chloramphenicol sensitivity [2].	20.60	20.60	20.70	22.00	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.76	0.71	-4.46	6	61	2012-10-02 17:35:21	2003-04-07 12:59:11	7	2	5	49	0	67	0	136.70	49	86.71	CHANGED	uFTsSGoTGTscLTVTEECpVpVsspssoKpRu-LsDuAhlGslolsApGCsTcp.sAL+AsusNYcssp.hhLhp-stps+lsV....sltAsDGs.sWTsDsushYRsssGsWsGolhllVcGDQsspPsGsYTLNL-GGYWsp	..............FTsSGoTGTscLTVTEECpVpVssho..soKsRupLs.-ustIGslsVpApGCsscQ.lAL+AssDNa-psp.hahhp-NspDKLhV....slpusDGS.uWTsDsGVaY+s........csGsWGGplsl.hVcGDQTspPsGsYTLsLsGGYWsc.....	0	0	0	0
+1129	PF03257	Adhesin_P1		Mycoplasma adhesin P1	Mifsud W	anon	Pfam-B_4117 (release 6.5)	Family	This family corresponds to a short 100 residue region found in adhesins from Mycoplasmas.	25.00	25.00	42.90	42.90	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.06	0.72	-3.67	7	75	2009-09-11 06:42:52	2003-04-07 12:59:11	8	2	7	0	10	73	0	87.40	58	10.15	CHANGED	pGSspptGS.oGo..SAGNPDSLcpDKlspSGpshTs.p......ouspssTNYTNLPP.s..........lTPTuDWPNALSFTNKN..NAQRsQLFLRGLLGS...IPVLVN+	..................................ptttS...uo..SAGNPsSLcpDKlop..SGps.os.p.....shsppcsTsYTNLPs.s...........loPTuDWsNALoFTNKN..NsQRsQLhLRGLLGo...IPVLlNK...........	0	9	9	9
+1130	PF00406	ADK	adenylatekinase; 	Adenylate kinase	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null --hand HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.92	0.71	-4.33	23	9734	2012-10-05 12:31:08	2003-04-07 12:59:11	17	83	7181	94	2694	6272	2767	160.60	42	74.26	CHANGED	llGsPGuGKGTQuppIsccaulsHlSTGDhLRApl.puGTplGcpAKphMDpGcLVPDElslsll+-cltps..ssppGFLLDGFPRTlsQA-uL-c....tshplDhVlpl-Vs--lllcRlouRhlp.ssGpsYah.apPP.c..hhsDhsup.LhpRuDDstEol++RLpsYpppTpPlI-aYppcGh	..............................................hhG.PGuGKGTp.........sth.lh...p....p....h..........t..h......s..p..l..S................sG....DhL.....R....u.........s....l......c....s..............s..........T......-.......L..........G............p..............p..................A...........K............sh...h..D......t...................G..p......L..V.......s....D.E.....l...l...........l...u...l.......l.+....-.R.....l...........s...................p...............s...........D..............s................p........p..........G.........F.......L.L.D.....G.F...PR.......T...ls.......QA.........-...u...........L.............c............c........................................................h..........u..............h.........s..............l..............D..........h..........V....l....ph..-.V.s.-..-.lll.c....R..hsGRthp.ssGtsYH.hapss....................................................................h.tshsDhsuttLh.RsDD.p.pE..T..l.+.p...Rlt..a...h.....p.........s...t...PlltaYtt...h............................................................................................................................................................................	1	926	1587	2197
+1131	PF05191	ADK_lid		Adenylate kinase, active site lid	Finn RD	anon	Manual 	Domain	Comparisons of adenylate kinases have revealed  a particular divergence in the active site lid. In some organisms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly  structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely  structural function [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.93	0.72	-4.29	141	6209	2009-01-15 18:05:59	2003-04-07 12:59:11	9	17	5432	61	1176	2972	552	36.00	57	18.92	CHANGED	RRlCts..CGpsYH........lhasP..PKhpGlCDhCGs..pLhpR.sD	....................RRsHhs..SGR.oYH........shaNP.........PK..........hEG.........K............D.Dl.TGE...-Ll.RcD..............	0	385	706	964
+1132	PF05221	AdoHcyase		S-adenosyl-L-homocysteine hydrolase	Finn RD	anon	Pfam-B_157 (release 2.1)	Domain	\N	25.00	25.00	25.20	27.90	24.40	24.20	hmmbuild  -o /dev/null --hand HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.67	0.70	-5.45	9	2525	2012-10-02 14:31:05	2003-04-07 12:59:11	12	10	2027	95	1084	2299	4318	421.00	48	95.54	CHANGED	tcYKVtDIuLAsFGRKEl-lAEsEMPGLMshRccYGsSQPLKGA+IuGCLHMTlQTAVLIETLsALGA-VRWuSCNIFSTQDaAAAAIA.........tuGlPVFAWKGET.EEYhWCl-pslp.asDG..tssNhILDDGGDhThLlpc.........................................KasphhtsIhGlSEETTTGVH+LYch.ppGpLhhPAINVNDSVTKSKFDNlYGCR-SLlDGl+RATDVMlAGKlAVVsGYGDVGKGCAuuL+GhGARVlVTElDPIsALQAuMEGapVsslE-lspcucl..hlsTsssssIlsscch.hhppsslssshtah-h-.psthhphsupcphsIKPQVDcahh.sGp+IILLAcGRLlNLGCATGHPSFVMSsSFTNQVLAQlELWspt..............ucY....cssVYlLPKpLDEcVAtLHLupLss+LTKLoccQAcYlGlPlpGPFKsDHYR	...........................................................................................................................capVtDl.u.LA..saGR+EIclAEpEMPGLM.u.lRccaus..pp.PL+GARIsG.s.LHMTlQTA...................VLIETLhALGA.-.V...R...WuSCNIa.STQDcA...AAA.l.A.............t.s.G.l.P.V..FAWK...GEo.-EYahshcpsl..a...........s.s...................ht.s.NhILDDGGDh.Thhl+..p.................................................ca..sch..hp.p...l............+G..loEETT......TGV.+.RLYphtcp....G...pL.hhPAI.NVNDSVTKSKFDNhYGCRcSLlDGIpRuTDlhlAGKhsVVsGYGDVGKGsAtuL+uhGApVhVTElDPIsALQAsM-GacVssh--ssppuD................................................................hhssssssphhhtphhthhptsshssssthtp.p..hthhthpshphhph+splcchhhssG+plIlLuEGRLlNLGsAoGHPSF.VMSsS.FsNQ...s..LAQI.ELapp.t.........................................s.pY......c...p.VY..h.LPKcL...DEcVApLHLpplGscLTpLop-QAcYlGlshpGPaKsphYR........................................................................................................................................................................................................................	0	369	670	896
+1133	PF00670	AdoHcyase_NAD	AdoHcyase; 	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	Bateman A, Griffiths-Jones SR, Finn RD	anon	Pfam-B_157 (release 2.1)	Domain	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.03	0.71	-4.40	16	2557	2012-10-10 17:06:42	2003-04-07 12:59:11	16	15	2063	95	1090	4107	3855	158.70	52	35.69	CHANGED	NLYGCRESLlDGI+RATDVMIuGKlAVVsGYGDVGKGCAtuL+uhGARVlVTElDPIsALQAuMEGapVsTlE-ssccucIFVTTTGN+DIIps-HhppMKcsAIVCNIGHFDsEIDVshLpss.uhcp.slKPQVD+aphss.G++IILLAEGRLlNLGCATG	..............................NhYGCRcSLl..DGI...p....R..u..T.D.l...h...lAG...K.....s.....sV.Vs.G.Y.G.D.............VGKGsAt.uL+.uhG.A...p...V.h.....V..T.....E...l..D.......P....I...s........A......L....Q....A.........s...M....-......G.......a....c.....V.....s.............s.............h.......-............-.........s............s...p...............p........u.....D...I.....a.....V....T....s.....T....G....N....p...c....lI...st.-.Hh.c.t..MKc.pA..IV..s.N.....I...G..H...FD..sEI.D.....l..s.s.L.cph....th..........p.h.pp.l.K.P......Q......VD...c.........h..........h........h........s......s........G.............+....p........llLLAE..GRLVNLGsATG...........................................................................	0	375	679	903
+1134	PF03747	ADP_ribosyl_GH	ADP-ribosyl_GH;	ADP-ribosylglycohydrolase	Bateman A	anon	COG1397	Family	This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine [1]. The family also includes  dinitrogenase reductase activating glycohydrolase [2]. Most surprisingly the family also includes jellyfish crystallins [2], these proteins appear to have lost the presumed active site residues.	26.10	26.10	26.20	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.93	0.70	-4.63	176	3139	2009-01-15 18:05:59	2003-04-07 12:59:11	9	53	1913	22	1016	2670	767	273.20	22	79.26	CHANGED	GullGtAlGDALG....h.shEh...hshs..plp.t.ht............................................................hh.ht..htsGph.....T....DDTphslslsculhp..........................................th.....s..ps.........hhpc.hht...........Whp...............................t.shshG.....ssstpul...............pph...ht..ut......t.t........................................................................ssus.GuhMRssPl.ul..hh...........s.pph...hp.hutpsutlTHssspuhtuuhhhAhhltth.lpGp.....s...htphhttt..................................th..tppphtptlpthhphtppst.............................................htthtssshshcslshulhshhp................sss........apculhtsls....hGGDoDosuAlsGulhGAha.G.h....ps...lPpp..W	.................................................................................................................................................................................................................uslhGtslGDA.hG..........h.shEh..........hshp.........plp..t.hs.h..............................................................................h.h.....h.ttu...ph.......................T.......................DDTt..hslslscuLhpt............................................tth........s...ps.................hhpp.h.t..................Whp..................................h.ttshG..................ss..sptul....................................pth.......pp.....st.............t.......................................................................tuhsN....GusM..RlsPl..uh.......hhst..............shpph.................hp.hsths.......u....ph..THsp.....s..h.u.ltuuhsh...Ahhlths....lp..Gt.........s...hpphhpth..................................................................................................................tt..pht.t.plphhhphhpptt.............................................................................hht.h..t.sss....t.....sh.-.sl.s.sAlhhhht.......................................................sss..........................hpcsl..hh.sss....h.G.G.........DoDThuA.........hsGu.....lsGAha.G.h.....ps........ls.................................................................................................	0	390	677	884
+1135	PF04587	ADP_PFK_GK		ADP-specific Phosphofructokinase/Glucokinase conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4731 (release 7.5)	Family	In archaea a novel type of glycolytic pathway exists that is deviant from the classical Embden-Meyerhof pathway. This pathway utilises two novel proteins: an ADP-dependent Glucokinase and an ADP-dependent Phosphofructokinase.  This conserved region is present at the C-terminal of both these proteins.  Interestingly this family contains sequences from higher eukaryotes. [1,2,3]. 	20.90	20.90	24.50	23.80	20.30	18.30	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.51	0.70	-6.27	9	234	2012-10-03 06:25:16	2003-04-07 12:59:11	10	6	153	7	154	223	1	386.20	27	87.69	CHANGED	slh+shulhhAYNsNlDAIh.hLpsE.....slp+hIpchGtcclh+t.EEhP+cIpp..-hlupllaul+pGKsAEl.lhs-c.l+pahtcpat..aDp.R....MGGQAGIhANlLuultshpVIsasPhLuKh.ApLF...sslhhPshEpGcLhLh..+E.acts-...sscIphIaEFp+G..FKlh..phpAP+usRFIsuuc.ps.s+l.h+--hpchLpEIuc.ps-hAIlSGhQulp.....ucstph.l+ps+EclplLpp.spsI+sHLEFAShs-cclRccll..plLshspSVGhsEsElApllplLGhc-LAccIhshsh.l.-ss.lhtuhlhL.c..s..............lchlphHTlhYhhhlT+tcs....EclccuLtFuslhAAs+AphGsIps.--l+.GLcVPhscpuphlcth.chcap.tcsh..h..........chc-YplshlPT+lVpcPhSTVGlGDTISouA.Flo.h	.....................................................................................................................................tlhluhssslDhlh.hl...........................ph.lpt...hs..h..p.h..........t.t..pph.....lps.t-l.htshhahhppGtuAEhhh.s...pp.hpphht...tht.......p..p........hGGs...Aulhupthu...h..t.s....hpV...lltsshhs+...tphh.....tt.l.hhP......tp...............................schHhIhEYptG....tphu....phpuPpuNRaIhspD.pN.sthp.....hh-.a.hp.........tLpc.......hp......sDlsllSGlp.hhc........s..p.s....tchhhccl...tc.l......p.lpp...spsl..l.HhEhAShsspclhpplhp.plh.PhVsSlGhNEpELh.lh...pshstsc.s.....h...thst..l..pss...l.chh...h...hlhcphs..................................LsR.lHhHTlsYphhhshpt.........hc.hppshthuuh.stssts.pt...........ss.hts...h-.s....c...h.s..L.chs..phhs.p.h..ct........c...h.h...p....tpsh.....h...........................pppshphhhsP.shlscpPh.p..TlGlGDsISutu.hh...........................................................................................................................	0	42	64	112
+1137	PF01117	Aerolysin		Aerolysin toxin	Finn RD, Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	This family represents the pore forming lobe of aerolysin.	24.30	24.30	24.60	24.70	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.28	0.70	-5.51	14	252	2012-10-01 20:43:00	2003-04-07 12:59:11	15	9	61	14	43	279	4	219.70	45	72.35	CHANGED	ss.h-VptcllspcspF.l+PluhL.AHhLGYAWsGGspupaVG.EDhslpRs....uD.uW.lpusssGs...CsGYR.CsE+hphplsNFpaslsspshpaGssp.pc+chlpTlsuhAhNpoDpspp.hllshphspoTsW.....SKTssashu-plthcspFcaP.hhG....cT-lslphpAsQsaoso.Nusopops.shpspspVPs+Sph.lplcla+oplshPYchph.hsYDl..phsGFLRWGGNAhh.sHPs.........NRPshsaTFs..hupspptupslhYQasH+hIsGps+aWDWsWslsc..GhushpaAhu....ssl.R.atuhloGpFpAtupasusI-hupshslsup.....phsphstpspttssshpl.hsshshcpLst	......................................................................................................................................................................t.t....h..h.hhN.sp..tp....hpht..h..ptsp...p..h.....shossht..hupp..lth..p.pa.phP..LsG...........coElulEluA..s..QSWAop..pG..GSTT.pol..S...ps...R..s...TVPs+SplPV+ltLYKusISYPY-FKAclp...................................................................................................................................................................................................................	0	15	29	36
+1138	PF05110	AF-4		AF-4 proto-oncoprotein	Moxon SJ	anon	Pfam-B_6407 (release 7.7)	Family	This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain.  Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].	29.90	29.90	30.20	30.70	28.90	29.80	hmmbuild  -o /dev/null HMM SEED	1191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.23	0.70	-14.19	0.70	-6.69	6	483	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	78	0	208	431	0	610.70	28	90.08	CHANGED	Yc-DRNlLRh+E+ERRNQEsQQ-c-AFPsshPLFuEPYK....TuKGDcLSSRIQsMLGNYDEMK-FLos+Sp.s+LsuhPpssss.SsscKscPpah.s-pRuputsuS.......pQSs+sossGPsPs.....ushSpSpKtops.....sS.+s+uussPuo..uoQc+spp........ptspp+tpupptu...-pu.p+p.SPhhuplspssss............pppuSS+..s..puusssuKpphpuKSP+-h-sshps.ppP.suhs.......uSuQhssQsF.PPSLhSKousMQQKPTAYVRPMDGQDQAPsESPELKsS...tEsYusQSapss.s-hKssA..KAKLoKL+IPSQslEsshSs-ssCVEEILKEMTHSWPPPLTAIHTPu+sEPSKFPFPTK-SQalosuoppQKphDsss+opsssppsp.SMLEDDLKLSSSEDSDsEQss..............-KsssRssP...sssspspsEsussu+uuSu.ScSsSESSSuSDSESESSSSDS...EsNEP.csuoPEPEPPoTNKWQLDNWLsKVssppss........PsusssopsPppps.cscG+spususp..s-s+-s..pSos+sttcsRsspKuPcsG+s+.QKSPspu....................-..sstRRolGKKQPKKsEKssus-t.psuh+sEpEsu..shtpusphssc+sKspTKGsp+sus+KEPKsulsss................uEK+KaKuso+sssKS+EhlE..TDSSoScSspc.......cuLP.......ssopSsGsscSspt.........RTsss.pushspssht+pp.....hhlPhc-sELLSPL+Ds-shps........LhVKIDLsLLSRIPt+.P.tcus.s+sscccs.stsp+csScstSEKuSsKuKRK+Ks-p-sctsspKKs+lEccsp........osuss.uspcsSps+sSpppStsKcc-hLPsP.u...Plsspo.Kst+su.KRshsppsosusssPpusspspSussssossKp++sEuKGusopctt+ssSsssssp...................................................................hPlPsLosusoKspRsKLsFDD.spsADaaMQEAKKLKHKADAhsD+FGKAlpYL-AVLSFIECGNAhEpsu.EuKSPYsMYSETV-LI+YsM+LKsauuPsAostDKpLAVLChRCpSLLYhRMF+LKKDpAlKYS+TLsEHFK.NSSKsAQAPSPsh...........u+usGsPSPlS.PpsSPuoSVGspSuuuSu.uusu..uoVoIPQ+IHpMAASYVsITSslLpAa-lW-QAEpLo+ENKEFFu-LDplMGPLshNSS.Ms-LV+.......YoRQGLphLRpsA+	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	20	34	93
+1139	PF03969	AFG1_ATPase		AFG1-like ATPase	Bateman A	anon	COG1485	Family	This family of proteins contains a P-loop motif and are predicted to be ATPases.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.27	0.70	-5.65	8	2702	2012-10-05 12:31:08	2003-04-07 12:59:11	11	19	1983	0	969	3282	2551	309.70	33	88.96	CHANGED	sTshpRY.pppLppsshhtDsAQusAlssL-cLtp...cltsushs+.t.....thhttLau+K...sttss+GLYlWGGVGRGKTaLMDsFFcuLPsppKtRsHFHcFMhcVH--LppLp..............ttsDPls.suDchss-splLCFDEFpVoDIuDAMlLupLhcALFsRGVoLVATSNhsPcsLY+sGLpRpcFLPtIshlcs+hpllsVDushDYRLRsLppA.hahhP.sttsptthsthapthh...ut.pstssL-lsuRtlps.ssssslstauFssLCpsspuspDYlsLuctFpTVhLssV.sMs.sccstA+RFIsLVDclYDpcl+LllS...AEs.hp-LYpuGch..tFEFpRshSRLhEMpS....t-alsRt	.................................................................................................t.a..t.lt..th.....D.s..hQtthh.t.t.hp.hhp....................th......t.......t.........t.........................hht.t.h........h...t................t.......................t......................ts...........s.........+...............G...LYhaG.sV.G.pGKTh....L.M....D....h....F....ap..s.l......P..................h.............p..........p..........K.......h..R...h...H...F.....H...pF.M..h....c.lH.p..clpt.lp.........................................................................s..p..t..sP..l...t...l.A.c....p.h.......t....tc.......s..p..l.LCFD...E...F.......V...o....D.I...s....D...A......M....l..Lu..p.......L...h...p...t.L....F...t..p...G..l..s...lVAT.SNh..sP...-...p...L......Y.......c...s....GL.pR..t..p.F.L..P.t.....I....sh.lpp..phplhp.l..D...u......s.....h.DYR....h.........c...............s...h...p....t........s.......t......h.......ah.........P..........h..........s......t..............p..........s..........p.........t..........t...........h.p.......p.......h...........a.......t..lss.....................t..t....t.........t.....s......................s.............l...p.......l...t......t.......R...l.....ts....................t...h..s..s..........t......s...h..hhsFtpL..C............t...........s..hutt.DYltLuchac...s.lhltsVPhhs.................................c..stA...RRFlsLlDthY..-pcl+Llho..............................Atssh.cl....a............t....tth...................thcatRshSRL.EMpst............................................................................................................................	2	276	558	798
+1140	PF01314	AFOR_C	AFOR; 	Aldehyde ferredoxin oxidoreductase, domains 2 & 3	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible  oxidation of aldehydes to their corresponding carboxylic acids  with their accompanying reduction of the redox protein ferredoxin.  This family is composed of two structural domains that bind the  tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR [1].	19.60	19.60	19.90	21.70	19.00	19.50	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.39	0.70	-5.78	112	1171	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	639	10	535	982	251	383.30	27	62.78	CHANGED	htchhpchhctlp...ssssht....shtpaGTssh.lphhs......phGshPs+Nap....puth..c............tAccluG-t.hpc.......phh.hppt....u......ChuCslsCu+.hschp.................................u.h..............................stsPEY..EshhuhGuss.....................GlsDlculhphNcLsschGlDoIShGssluhsMEhhE+Gh...ltct.h........shtlp.aGss-ullchlcclAhRcG.lGchLApGstchucch..G.s.-...hu..h.pV......K....Gh.EhPuaDPRuhp...G...huLuYATusRGusHl..cu........a.shs.-hh.......s.................thD.h.............th...........csKs.phlthhpchpul.....hDShslCtFssh.................................hshpth...............................schlsAsTGhc.hos--lhps.GERIasLcRhaNl.+t......G....hst.pcDsLPpRh..hcc.......Ph.pGs..scGp.....lsp..lcchLscYYchRGWc.ppGhPot-pLccLGL	...............................................................................................................hhtp..chl....pss.sh.....s.tphGTshh..l.hhs......ctGtlPstNhp.............psta....p..............htpthshts....htc...........phh....s+....hp....u...........C......a.uCPltCtp..hp.h...........................................................ps.Ea..-slhuhGuss....................................................s...sc.ltss..h..hs.pl....s--hGlDs..hshG.p.hhu...hhh-h...hp+...Glhpc..........................h.tl..c...h...GD..sph..hh..c.hh...c.lApR......pG...hhshLA.c.G....sht....h....Acp..a........s..sp-..........hh......h..hs................................K.....sh.th.P.....sac.s.pthp.....G.....h.l.s.hhh.sp.c.s.t.sHh.ch...............................h.hlth-lh.................G.................tthD.h.....p....................-uKh.chsth.t.h.s.sl.....hsulslCt.ash......s.............................hsh.th.h............................................schhpA...h.TG.c..hot-c.L...hh.u-RIhsLcRtash+h..h...........h.pp.pcD..hlP..phh..hcc.............................sh.s...p..Gs..tp........hsct.hct.Ls.aYp.hGWs.p.G.hPstppLpcLsl.......................................................................................................................................................	0	220	395	470
+1141	PF02730	AFOR_N		Aldehyde ferredoxin oxidoreductase, N-terminal domain	Finn RD, Bateman A, Marshall M	anon	Sarah Teichmann	Domain	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This domain interacts with the tungsten cofactor [1].	20.80	20.80	29.70	34.50	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.13	0.71	-4.98	111	1162	2009-09-12 00:12:13	2003-04-07 12:59:11	10	5	646	10	533	979	183	199.10	39	32.36	CHANGED	atG...+lL+VsLostphph-plstc.hh+palGG+GLus+ll.hccl.ss.........psDPLuP-.NhLlassGPLTGo..sPsuuRhslss.KS....PLTG..........slssSssGGtauspLKhAGaD..ulllcG+uccPV...YLhIc.cs........plElc-AscLW....G.pssh-TpctLpcch.......t.................spVhsIGPAGEphVtaAsIhs....-t..tR.......uAGRu.GhGAV.MGSKpLKAIsV+....Gsp	........................ahsplLRVsLos...s....slphE....chsc...hcpalGGhGhuh+lha-cl..ss.........sscP.h.s.p..NtLlFusGPLoGos.sPs.ouRhslss..hS..........PhTs..........hls-uphGG.hausphKhA..GaD..slllcG..+..u..c..pPV...a..LhIc..--...........c..Vpl....c..c.....A..s...t..LW.........G......csshtTsctlpcth.s...c......................ssVssIG.AGEN..hV...h.uslhs........sp......p+................uG.RuGsGAV..M.G.S.KNLKAIsVcGs................................	0	222	394	469
+1142	PF02420	AFP		Insect antifreeze protein repeat	Bateman A	anon	[1]	Repeat	This family of extracellular proteins is involved in stopping the formation of ice crystals at low temperatures. The proteins are composed of a 12 residue repeat that forms a structural repeat. The structure of the repeats is a beta helix [1]. Each repeat contains two cys residues that form a disulphide bridge.	36.50	2.00	36.60	2.50	35.20	1.90	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.25	0.75	-6.12	0.75	-3.10	9	502	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	7	21	7	518	0	11.70	45	80.61	CHANGED	TCTsSpsCspAp	..sCTsSssCspA....	0	0	7	7
+1143	PF03756	AfsA	AfsA_repeat; 	A-factor biosynthesis hotdog domain	Yeats C, Bateman A	anon	Yeats C	Domain	The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain [2].	21.30	21.30	21.30	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.60	0.71	-4.43	34	276	2012-10-02 20:54:35	2003-04-07 12:59:11	8	5	116	0	114	312	5	127.30	20	65.85	CHANGED	hVHRtsss-VlLossppt.....sththphphspsHshhas+...ssDHhsuhLlhEuhRQuuhhlsHsth.tlshshthlhhshshsatchschss.....Pshlpspssssssp.......t...sphphplslhQsGpllusushssss	.................................VtRt.pstpVllsshtph.........sth........ph.th.p.h........s..psHshhh-+.....ssc...H..hsshl.LhEusRQsuhh..hs...ptth.....hs...............t....h..lhp.s.h...s.hshpp.hs.phss........Psplpspss.ssshp..............tthph..phphhpsuphsspsphph..h................................................	0	16	76	106
+1144	PF04671	Ag332		Erythrocyte membrane-associated giant protein antigen 332 	Waterfield DI, Finn RD	anon	Pfam-B_4587 (release 7.5)	Repeat	To date many different Plasmodium antigens recognised by the hyperimmune system human sera have been cloned, sequenced and characterised.  The majority contain tandemly repeated amino acid sequences which make up a considerable portion of the protein sequence. It has been suggested that these repeat-containing antigens may provide an immunological 'smokescreen' to the parasite in order to evade the human immune system. This repeat is found exclusively in the Plasmodium falciparum Ag332 protein and occupies most of its length [1].	20.70	20.70	61.00	20.70	18.40	20.60	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.49	0.73	-6.65	0.73	-4.03	41	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	2	0	29	71	0	21.20	52	11.32	CHANGED	sSlsEEllE.-GSsTE-lVppc	.sSloEEIVE.-GSsTE-lVcpp.	0	29	29	29
+1145	PF01453	B_lectin	Agglutinin; MMBL2; MMBL; Agglutinin;	D-mannose binding lectin	Bateman A, Griffiths-Jones SR, Studholme DJ	anon	Prodom_2511 (release 99.1)	Domain	These proteins include mannose-specific lectins from plants[1] as well as bacteriocins from bacteria [2].	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.15	0.71	-4.19	128	2897	2009-09-13 13:36:34	2003-04-07 12:59:11	19	158	299	65	1397	2960	33	103.90	30	18.28	CHANGED	spshlW.....ANpt.....pPl..................s.pLplpt.DGs..LVLh.s..ss..........................t....lWuo..........ssssss..sssh....spL.c.sGNLVl.h....t.............sspslWpS.......F..cpP.scohLsstph....t.hs.t.p....hsuWposs...........ssu	...........................................thlW....hANpp...............pPl.............s........upLplst...s...Gs.........LVLh...s..ts..........................sps...lWoo.......................sos..sts.....tssh..........upLh...c.sGNLVlt...s..s................ssphlW...Q.S.......F...DaP..oDTlLPt.pls.h..s.hh...t.t........hhshts.....................................................	0	123	873	1179
+1146	PF05039	Agouti	agouti; 	Agouti protein	Moxon SJ	anon	Pfam-B_5381 (release 7.7)	Family	The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation [1] [2].	21.80	21.80	21.90	21.80	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.33	0.72	-10.99	0.72	-3.64	9	278	2012-10-01 22:06:18	2003-04-07 12:59:11	7	1	126	6	49	243	1	92.60	45	71.89	CHANGED	tcu-pth.............plsshuLs.slcphstpptcpc....p+hshhc.phLs.......R.s..sPpRCltLt-SChu.tsPCCDPCAoCaCRhFpshCYCRph	.................................................s....p.h..s..........pluhl..uLppc.Kphohp.EAEtp......p+.ph.pc..s..p..thphA.......tsRss....sPpsCVsp+-SChs.ssssCCDPCAoCpCRFFpohC.CRh.h.....	0	2	4	16
+1147	PF04647	AgrB		Accessory gene regulator B	Finn RD	anon	Pfam-B_5200 (release 7.5)	Family	The arg locus consists of two transcripts: RNAII and RNAIII. RNAII encodes four genes (agrA, B, C, and D) whose gene products assemble a quorum sensing system.  AgrB and AgrD are essential for the production of the autoinducing peptide which functions as a signal for quorum sensing.  AgrB is a transmembrane protein [1].	23.00	23.00	28.30	28.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.36	0.71	-5.22	56	789	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	539	0	119	491	7	179.40	24	93.29	CHANGED	pl.scphsphl....tpptslscpchthlpYGhpllltslhKhlhlllluhlhshhh.sllhhlshhhlRhauGGhHupo.hpChlholhhhlshshls.thhthshh......hhlhh.....hlhuhlllhhaAPssotp+Pltspc....hc+phKhtulhhhhlhhllslhlh.............hhphlhhulhhpsls..lhslsh..phhp	.....................hhcphuphl....ppcpsl-.c...ph.hlcaGhpllhtslhphllhhhluhlh.shhh.ollshlsahhlRpautGhHApophhChl.olllalh....h....shlh.hp...h.p.lshh........hhlhl....hllulhllhha....APssocpp.Pl.stc....hh+p..h...Kh..h...ullh...h..h..lhh...l.ls.Lhlh.............hsphlhh.Glll.psls..lhPlhh.h..p...............................	0	69	107	116
+1148	PF04730	Agro_virD5		Agrobacterium VirD5 protein	Mifsud W	anon	Pfam-B_3261 (release 7.5)	Family	The virD operon in Agrobacterium encodes a site-specific endonuclease, and a number of other poorly characterised products. This family represents the VirD5 protein.	25.00	25.00	628.50	219.50	17.30	20.70	hmmbuild  -o /dev/null HMM SEED	774	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.53	0.70	-13.41	0.70	-6.48	5	19	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	5	0	4	20	0	432.90	50	93.94	CHANGED	KLGAAERuAYEsWssusRPTWKDLIL+ARLDAIDSSAWLsDl.......................................................................................................................................uEsTSSTFcYEGlPLGEGER+AYEcWQEDAQPTWE-LVVNARlsELs+suuIssEasuLpEshEhRSDAsKRKRccsIDQ+so.SuSFpYDGMRLGuPERtAhtsWucspPPo.p-LllcuRlpuIssSsWh.sp.ssoS.FEYpGhPLGpsER.AhcpW.tsAQPsWEDLVVsARh...AELh.uu.h.sp+...p.tt-.s.ptp.Rh..hPI.tcp.sts.FlYDGhtLGAsERAAY-RWSKP-RPTWEDLILDARQAAIESDuVSsstIGKoSSSVFLYEGMSLGDAERQAYGRWRQPAQPRWQNLVVNARLAELDPSAWIPDEHDPFE-GEAsuhsSQASsANKSssuLGsQS-S+RPuhA+EssQEsTHlQsPoCSQLETRRALaFGSSGRDAspTESIAcsNRlDGVGKVKRLGoKSRRuVsATsHuVsSSscRLLS-EsGppAssSsPEKsVRSRoDNIGTYGSRKNERARLATETGKYESEHIFGFKVVHDTLRATKEGRRLERPMPAYLECKELHRQHVGTGRGRTRLVGRGWPDDASYRSDQRATLSDPVASuEGATASNGYQLNQLGYAHQLANDGLQSETPDGVsMPIQVATTSYNYTVSRDPVLSPPSKEQAPQLLHLGPRGQTEAVLARETALTGKWPTLEREQQVYREFLALYDVKKDLEAKsLGVRQKKpALVSALNRTAuLIGASPhKAQSssAEVEpusDEhDERRVYDPRDRuRDKAFsR	......................ERtAY-sWstst.PTWKDLllpARlssIDussW..phtEsosSsFhYEGlPLGEGERpAYcpWtEsAQPoWEcLVlsARhtpLstst.IssEhssLpps.phRu-u.K+phpp.hDpcps.stuF.aDGM+LGpPE+tAYt...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	4	4
+1149	PF00578	AhpC-TSA		AhpC/TSA family	Bateman A	anon	MRC-LMB Genome group	Domain	This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA). 	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.35	0.71	-4.44	124	16547	2012-10-03 14:45:55	2003-04-07 12:59:11	16	104	4711	453	5334	26489	14345	127.90	25	62.99	CHANGED	lGppA.P..-..Fplt.......st..p...s...pp.lsL.s-h...pG..phllLhF...ast.sasssCs.pEhsshpchh.pcap.pt.ss.pllulSs.Dsht.........stppahcphp.................lsaPlluD....sppluctYGlh............................hshtssalIDtc....Ghlphh	...................................................up.s.P..s...F.p.ht...............st....p.........h......pp...l.s..l....s-h................pG.......+h.s.l...l...h....F..................a.....Pt...s.....aT.......s....s...............Cs.....s....E..h..s...s....h...p......c....h...h......p.....c...a......p......p..........t......s.......s......p.....l......l..u...l......S......s.....D...s..ht.............................sp..p...s.a...t.p.ptp..................................................ls..a..s...l....l......u...D.............s...p.....p......l....s....c...t...a..s.l.h..t.................................................................h.s.hR...s....o....F.l...l.Ds.c...Ghlp..h..........................................................................................................	1	1910	3591	4647
+1150	PF02626	AHS2	DUF183; 	Allophanate hydrolase subunit 2	Mian N, Bateman A	anon	COG1984	Family	This domain forms the second subunit of allophanate hydrolase. In yeast urea amidolyase (Swiss:P32528) this domain is found between Pfam:PF00289 and Pfam:PF00364.	25.00	25.00	25.10	25.90	23.60	24.70	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.44	0.70	-5.10	160	3169	2009-01-15 18:05:59	2003-04-07 12:59:11	10	21	2343	11	754	2303	1607	265.10	35	59.05	CHANGED	chGlssuGAhDthAhphANtLlGNs..sssAslElshs..Gsplch.ppssh.lAlTGAshsspl..........sG...ps.....lsha.pshtlpsGshLpluts.p..pGsRu.YLAltGGl.sls.hlG.SpSThhtuslGGh........tGc.sLpsGDhLslsssssttstht.........................h..thhsthsp..pht.l.RVl.GPph..chFoppshppahsspaplosposRMGhRL..p....Gs.slp............spstslhS-ulsh.GulQlPssGpPIlLhsDpQTsGGYP+IusVlssDLs+LAQhpPG.spl+FphlshppA	............................hGls.uGAhDphAhchANhLVGNs..tssuuLEl.Tl.........t....sssl....cF....p....s....s.sh.lAlTG.As.h.p.spL.............................-s.....ps........l.....hh..pshhlctGphLpl.........sts...p......pG....hRu.YLAV.uG.G.l....s.........V.ss.h..h.G.SpSTphpuulGGh........pGR...hLpsGDhL.slspsttthttht..........................................h..h....p...h.st........sst..l..+ll.GPph..chFscpuhpsFh.p.s.s.........aplospSsRhGhRL....p.........Gt..hhp.....................tpsp-lhS.cu.hsh.GslQVPssGpPIlLhsDt.TsGGYPpIusl.hpsDL.+LAQ.htsG.spl+Fh.hshpp.....................................	0	197	420	621
+1151	PF01808	AICARFT_IMPCHas		AICARFT/IMPCHase bienzyme	Bashton M, Bateman A, Iyer LM, Zhang D, Aravind L	anon	Pfam-B_1613 (release 4.2)	Family	This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide  ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate [1]. This is catalysed by a pair of C-terminal deaminase fold domains in the protein [3], where the active site is formed by the dimeric interface of two monomeric units [3]. The last  step is catalysed by the N-terminal IMP (Inosine monophosphate)  cyclohydrolase domain EC:3.5.4.10 (IMPCHase), cyclizing FAICAR  (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP [1]. 	25.00	25.00	25.00	25.90	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.91	0.70	-5.33	9	4880	2012-10-02 00:10:39	2003-04-07 12:59:11	13	11	4399	36	1208	3788	3760	297.20	42	60.59	CHANGED	AAKNHtcVsIlsDPtDYssllpchcp.pGp.lohppRpcLAhKAFpHTAtYDusIusaFpp.hu..............tt.s...shshhcp.sLRYGENPHQpu.hhhphs.tch....lssAp.LpGKthSYNNlhDADuAhphV+Eap.....PAsshlKHsNPCGlAlG.....................sslt-AYsRAhpAD.hSuFGGlIAhNccVDstTAchIpp...........FsEllIAPuYstEALclLs+K.KNlRllhhthssph...ph-h+pVtGGhLhQcpD...tshhstsphp.lVoKppss..EppLpDLlhAWpslKasKSNAlVhAKNshslGlGAGQ.SRVcus+lAh.KA	.........................................AAKNats....VsllscssDYstllpclp........t.....t.....G..s.....hoh..pp.....RhpLAhKAFpHTAsYDuhIusYhsp......hs................................................t.t.h..P..p.t...h...sh.sh.....p....p.p.shRYGENPHQpAuaYhp..st..s.t.p................u.l..A.s.......A.....c...QL........p..G.Kt.LSYNNltDsDAAhch....V+-F..s............................pPAsshlKH.....sN....PC.GlAlu.......................................s.s.lhpAYp...+Aa......tsDshSuFGGIlAhNRpl.D.ttTAct...ltp.......................FhEllIAPuasp-A.LclL...st....K....K....NlRlLt......h..........s..............................s.....p...............t.................s.......t........h-.....h......+.p.V.s..G.G.lLlQ.........sp..D.................h.h.h...s.......t...p.h.........p...........lV.T..........c........+...p.................P.............o....-p................ch.....pDLh.FAW+ss.KaVKSNAI..lh...u.........+.....s...s.....h....TlG...lGAGQhsRV....tSs.+.lAht+.............................................	0	404	789	1035
+1152	PF04548	AIG1		AIG1 family	Bateman A	anon	Pfam-B_1846 (release 7.5)	Family	Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.37	0.70	-5.23	32	1778	2012-10-05 12:31:08	2003-04-07 12:59:11	11	41	154	28	1094	11277	2366	173.00	24	40.10	CHANGED	hsllLVG+TGsGKSATGNSI.....LGccs.....FpS+hpupuVTppCpttss.p.cG...pplsVIDTPG...L.F-hp.s..s...s-.hs+EIh+ChhLupsG.HAlL....LV..hslt.RhTpE-ppslpplptlFGsplhcahIllFTpt--Ltsss..L-DYlppssschLppllp.CssRhshFsN+..ssttc+tpQlppLLshVpslhppNs..G.t.aosc.hacphpppt....p.thpppp	.............................................pllllG+.oGsGKS....uh....sN....ol...........................L..G..p....p.h.......................F...p.......s....p....h......s.........s....p......s.....s........T......p.....p....s......p.......t....t...........p.......t.......p........h......p..G...................p.p..l........s.......l.l..DTPG..........h....h....cs...p...h......p......p.p...p....h..h..p...p...l.....h...p.....t...h............h........p...t...s.....u.........c.....s....h.l......lV.....h.p..hs.....+h.o...p..p.....-.p.....p..h.....l.p....h.....l.p...p...h....F......G.........p...p......h..h..c...h...s..l.l..l..h..T..p......t..c...p.....h.....t..s...tt........hp..p....h...ht......................h......t.l.....h.t....h...t.............................................................................................................................ttt.................................................................................................................................................	1	345	637	860
+1153	PF00731	AIRC		AIR carboxylase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_462 (release 2.1)	Domain	Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	29.30	29.30	29.80	29.70	28.80	29.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.83	0.71	-4.93	224	5292	2009-01-15 18:05:59	2003-04-07 12:59:11	15	19	4504	106	1483	3728	2423	147.40	46	73.54	CHANGED	shVuIlMGScSDhssM.......ccAsclLcc.hG..............lsaEscVlSAHRTP-chhcaAcsAcp.+GlcVIIAGAGG.AAHLPGMlAuhT.sLPVIGVPVp........op.sLsGhDSLLSIVQMPsGlPVATlAIG..GApNAuLLAspILuhp....Dsp.ltp+LppaRpphpppV	.................................................hVullMGSpSDas.sM.......pcAu.p.h.L.-p..hu....................ls....a....E....s....c.V...lSAHRTP-hhhpaAcpAcp...+G...h..c..V.IIAGAGG.AAHL.PGMlAuhT.slPVIGV..P.Vp..............op...s...L...sGhDSLhSIVQMPs...Gl..P..V..A..T..l..AIG.....sGAtNAuLLAspILuh..p....c.p.....lt....p+lttacpt.pp...................................................	0	517	988	1277
+1154	PF00586	AIRS		AIR synthase related protein, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome Group	Domain	This family includes Hydrogen expression/formation protein  HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain [1].	21.00	11.40	21.10	11.40	20.60	11.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.29	0.72	-3.75	856	17593	2009-01-15 18:05:59	2003-04-07 12:59:11	19	63	4701	78	4854	13670	7415	103.20	23	21.07	CHANGED	G.-DuAllchs....................................sttlshss.Dshsstsp...........h.sshs...hGtpulusslsDls..uhGA.cPl.shhsslsh.......t.........t.........................................l.pphlpGhscssp..phGs...sllGGco	....................................................................................tsuulhp.ls...................................tptt.ls..hssDth.s..s....psc.......................t.ps.hs....hGtpulusslsDlh................shG..A..c.P.........l...hh.hshlsh............sp.h...ssp.h...........................................h.ptllp.....Ghuptsp...ph..Gh.......sllGGcs.......................................................	0	1572	3133	4132
+1155	PF02769	AIRS_C		AIR synthase related protein, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome Group	Domain	This family includes Hydrogen expression/formation protein  HypE Swiss:P24193, AIR synthases Swiss:P08178 EC:6.3.3.1, FGAM synthase Swiss:P35852 EC:6.3.5.3 and selenide, water dikinase Swiss:P16456 EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.95	0.71	-4.21	169	19206	2009-01-15 18:05:59	2003-04-07 12:59:11	17	69	4747	77	5269	15059	7896	157.80	18	34.84	CHANGED	psGDhllhlus........sGltusuhhtttphhttss.................hs-hhhp.phlhhhhhhhth....thlpuhpDlosGGLssslsEhs.t.sthGhplshs........................shhp.h............h-hhhs..................................tspGthhlslssppt....pphhphhp..pht......shhlGplssptththhht	...................................................................................sGshllhhus......................Ght..usu....h..s...h..h...p..p.h.h.t.tss.h................................................hscsh.h..p.......p.h..hp.....s...h..tt....hhth...............shl.....p..uhpDlo.sGGL...h.....s............slsc.....hs...t..s.....u......t......h........usp...l.chs..................................h.shh..p.h..............................t.h-...h.h.hs......................................................................................................tsp....u...t....h.....l.l.s...l...ssppt.........p..thh.t.h.hp........p..t.sh.........t.....shhIGplspptt......ht..................................................................................................................	0	1677	3348	4466
+1156	PF04988	AKAP95		A-kinase anchoring protein 95 (AKAP95)	Moxon SJ	anon	Pfam-B_5366 (release 7.6)	Family	A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic  chromosome condensation by acting as a targeting molecule for the  condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA [1].	24.40	24.40	24.40	26.90	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.47	9	156	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	41	0	77	134	1	157.10	53	28.51	CHANGED	FsCShCKFRTFp-c-IppHhpSshH+Epl+al..ps+LsK.sh-FLpEYlsNKhKKTtpc+pphpsppthhpph...tDlhcGlu.-cFMpKVEAsHCuACDlaIPshapslQcHL+S.sHspNR+thhEQhK+sSlhsA+SILNN+hltp+LE+YlKGENPFssssc-	.....................FsCSlCKFRoFp-cEIppHL-S+FHKEph+aI..uTKLPKpTs-FLQEYlsNKsKKT-pR+pphpsppsshpph..-pDlhculu..hEHFh+KVEAA...HCuACDlaIPhpasllQ+HLKSsDHN+NR+hhhEQ.K+sSLhVA+SIL...NN+hIsc+LE+YLKGENPFssps..t................	0	3	8	28
+1157	PF02983	Pro_Al_protease	AL_protease; 	Alpha-lytic protease prodomain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.50	20.50	21.10	21.10	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.07	0.72	-4.01	35	302	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	88	14	99	313	0	59.80	28	15.82	CHANGED	polucLcuspssL.s........sush...susuWaVDspoNcVVVsucsss...uusshschuussuutss	........................ohspLcuupspL.s.............sAsh......ssou..WhVDspoNpVVVs.sssss.....susphsphstssss.s.t......................	0	32	73	96
+1159	PF00490	ALAD		Delta-aminolevulinic acid dehydratase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.90	21.90	22.50	23.40	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.83	0.70	-5.54	165	3912	2012-10-03 05:58:16	2003-04-07 12:59:11	16	9	3698	72	1117	2899	2727	314.40	48	95.89	CHANGED	hshpR.RRhRpstslRclVpE.TpLsssDLIhPlFVp-Gps...pp.IsSMPGlhRhS.l.DpLhcpsccshplGIsulhLFGl...s.pt..KDttGopA..as.ssGllpcAlRtlKcth.P-.lhllsDVsLstYTsHGHsGll......................t..s..pl.NDtTlchLs+tAlupAcAGADllAPSDMMDGRVuAIRpALDps.GapclsIMSYuAKYASuFYGPFR-AssSu..sphG.............D++oYQMDP.A.NscEAlREltLDlpEGADhlMVKPuhsYLDll+cl+cpa.s...lPlsAYpVSGEYAMlKAAAp..pGWlD.cccllhEoLhuhKRAGADhIlTYaAh-sA..c.hL	.......................h..hpR.RRlRpsshhRphl.p..E..s....p.L.s.........s..sDLIhPlFVh..........-G..p.s......p..ptl..sSMPGVh.Rh......o......l..-.pLh.ccscchsp....hGItu.lhLFGl......s.pp....KDtt...GopA..as..-.Gllp+AlR.t.lKpp..h..P-.l.........hlhsDlCLstYTsHGHCGll....................csu..tV.NDtTlchLs+pAlu.....pAcAGADllAPSsMMDGplsAIRpALDp......s...G.a.p.s..ssIMuYosK..YASu...FYGPF.R.........DAssSu..sp.hG.............DRKoYQMDPu.N.p.cEAlREsthDltEGADhlMVKPuhsYLDllRcl+-...ph....p....lPlsAYQVSGEYAMlKAAAt...sGW.lD.cccllhE..oLhuhKRA..GADhIlTYaAh-sAch..........................................	0	362	710	948
+1160	PF00171	Aldedh	aldedh; 	Aldehyde dehydrogenase family	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases Swiss:P00352 EC:1.2.1.3. Succinate-semialdehyde dehydrogenase Swiss:P25526 EC:1.2.1.16. Lactaldehyde dehydrogenase Swiss:P25553 EC:1.2.1.22. Benzaldehyde dehydrogenase Swiss:P43503 EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase Swiss:Q02252 EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase Swiss:P81406 EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase Swiss:P30038 EC: 1.5.1.12. Acetaldehyde dehydrogenase Swiss:P17547 EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase Swiss:P07004 EC:1.2.1.41. This family also includes omega crystallin Swiss:P30842 an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.37	0.70	-6.16	119	43773	2012-10-02 17:28:28	2003-04-07 12:59:11	17	120	5325	607	12917	36315	23835	407.20	25	80.35	CHANGED	ahsups.......pp.hpshsPu.....sschlupls.tustp.Dl-pAlpuAcp.Ahp.......t...W.pphsstcRuplLt+hAchlc.p+t--lApl.sh-sGKslt...pupt.-ls.ts.....hshhcaaAsh..scc.hpG.ph......hs..s..........sthshsh+p.Pl.GVlusIsPWNaPlhhs.shKluPALAsGNolVlK.Pup.TPlou.hhluclhp-.A....GlPsGVlNll...sG..GppsGpsls.pcsplctloFTGSotsGcplhpt.Au..pp...l....K+lsLELGGKs.....shIVhsDA.D.l.-tAlpsslhut.ahssGQsChusoRllVpcu.la-c..Flcclspts.ppl.clGs...P.h-..........ssplGPllsppphc+lpphlppuhpcGAclls.GG..............tpG.halpPTlh...ss.VsschplhpEElFGPVlslhpac..s.......-EA.lphANsopYGLuuulaTpDls+uhchucpl..csGtValNsh...tsss.ts..PFGGhKpSG.hG..R-sG.ttulcpasphKsl	.......................................................................................................................................................................................................h.sP.............st.p....h..t..t...h..........s...........s......t...c.l..p.t.A.l....t..s...A..pt...Aht.......................t.W...t.p..h..s...s..t.p...........R........s........p....h...L........t..........c.h........u........p............h..l..........p........p........p...........t..........c......p.....l..........u.......t........h................s........h.........-..........t........G............K..s..ht..............p.uts........-....lt....t.s.......................h.p.h.h.....c.a..h..u...th.......sc...p.....h......t.....s....ph..............................h....t...............tshh..s.h.h.h.p...p.....P..l....G....V........l....us..I............s..P...a..N....a....Ph......h...h...s...s..h.ph..u....s.A............L..s..s..G.N.s..l..l.l....K....P.u.....p....p....s.....s.....h....s....s.....h.....h....l.....s.....c.....l....h....p....c....A......................G.l.P...t...G...l....l..s.l.l............t.G.......u.....t....p.....s.....u...p...t...L........h....p..c.......s...t...l....sh..............l..............s......F.T..G....S.s..t.....s........G..c....t..l.....h........p.....t...uu........tp........h..................p....l..hhE......h........G.Gp..s.....s.h.l.....V......h.....s........-......A.......D......l.......-.....t.....A...l...p.......s.h...h..t..........u...t.....h.......h..s....s...GQ.......h.C.......s...u..s.p...p.........l.l.V..p.........c.........s.........l.........h......-.p.........hhpt...l.........h.......t.t.......h.....p......p......h.......p....h......G.s......s...hp........................ts...t...h..G.s.....l...l......s.t.t........t.h..p....p..l.............t.h...l...p...t...u...h....t......p.....G......u...p.....l...h.h....uG.............................tt........G....h.a...ht.P....T.....lh...................t...t....s.t............p......h.....t...l....h.....p............c.....E..........h..F.....G.....P.....lhs..........l.h.t.hp.....s...............................c...-..s.....l....t....h....s.....N....s....s....t...............a....G..L.....s.........u...s.........l.......a.....o......p......s........h......t......p......s..........h......p.....................h...t.......p...t.l..........cs....G.........h.....l..............h........l.......Nt..........................s................h................s........FG.................G....h........t..t..S...........G....h.G....pt.u....s.ht.a.p.p................................................................................................................................................................	0	3478	7376	10497
+1161	PF01081	Aldolase		KDPG and KHG aldolase	Finn RD, Bateman A	anon	Prosite	Family	This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate  aldolase (KDPG-aldolase)	22.20	22.20	22.30	23.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.02	0.71	-5.14	5	4204	2012-10-03 05:58:16	2003-04-07 12:59:11	14	12	2642	49	825	2763	739	192.20	33	90.12	CHANGED	I-ulL+cA+llPVIslcct-DAlPlA-ALlAGGlRVLEVTLRTpsAlDAI+hlt+pRP-hlVGAGTVLsApQlupApcAGAQFlVSPGLTsDLlKtus-schPLlPGVuTPSEIMlGL-hGlccFKFFPAEssGGVsAlKAlAGPFuQVRFCPTGGIsPuNlRDYLAlPullClGGSWlVsuuhlpssDas+IspL	..........................................h....hppt.sllsVlts.ps.h.-cA.lshucAL.lpGG.lp.s.lElTh......p......o......s.....s......A....h......c........u....I....c....t...l....t.................c........p.....h.....s....c.........s.l.l..GAGTVLssp..psctsh.pAGA...pFlVSP.u.h.st...pllctsp.p.t....slP......hlPGssTsoElhtAh.-hGh.chlKhF..PA..p..sh..G.....ss..hl+Alt..u..P..h.s..p..l..p.h.h.P.TGGlo..s..s..N..htcalshs.s.lss.s.hG.S.hL.ss.ts....t.t.tpattlt..................................	0	228	513	683
+1162	PF00596	Aldolase_II	Aldolase_class_II; 	Class II Aldolase and Adducin N-terminal domain	Bateman A	anon	MRC-LMB Genome Group	Domain	This family includes class II aldolases and adducins which have not been ascribed any enzymatic function.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.46	0.71	-4.68	502	9699	2009-01-15 18:05:59	2003-04-07 12:59:11	16	32	3654	97	2299	6508	3435	184.40	24	69.68	CHANGED	pc.l....stss+hhs.phGh.sp.ussGslSs..+..............................s...............tsthl.lsPo..Ghphsplp...s.scllhl.....c...h........c.G..phl.....................t.................t...pso............u-hshHttlapt.....ps.-spullHsHoshusuhu.h...................tp.l....s.....hstptst.h...........splsh.............h..hp.......G..tl....................u..pplspsht.......t...........................s.p...ulllpsH..GllshG......p.oltcAhhhhhhl....Epsschtl	............................................................................plhpsstths..phGh..s........p..hstGNl..Ss...p........................................t............psthl.I....pPo...Gh...t.ap...pls.......s..schl..hl...c...h........s.G.....chl....................................pt.......................thpPS......u-.hsh.HhtlYpt...............hs.ch.....tullHsHos..tusuhu.h.................................spsl...s...............hshptst..hhh......................sslsh..................h..h.hs........u.p..pcl..........................ups.ls..csht.........................................ptt..ulLlpsH....Ghhsh.G........c.s.hpcAht.hh.hlEpsAph..h......................................................	0	668	1344	1864
+1163	PF03752	ALF	DUF312; 	Short repeats of unknown function	Yeats C	anon	Yeats C	Repeat	This set of repeats is found in a small family of secreted proteins of no known function, though they are possibly involved in signal transduction. ALF stands for Alanine-rich (AL) - conserved Phenylalanine (F).	20.80	20.80	21.00	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.82	0.72	-4.10	42	301	2009-01-15 18:05:59	2003-04-07 12:59:11	8	24	42	0	140	347	0	41.90	30	20.81	CHANGED	Rsslsplhssu..GssVppAAptAL....sGsspslcsFLpsG.htAt	...............Rhtssplhssu....GssV+pAAptAL....sGo.spslcpFLpsG.h.A........	0	39	110	133
+1164	PF05208	ALG3		ALG3 protein	Wood V, Bateman A	anon	Pfam-B_3416 (release 7.7)	Family	The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man [3]. ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.	21.50	21.50	21.70	22.00	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.58	0.70	-5.23	7	352	2012-10-03 03:08:05	2003-04-07 12:59:11	8	7	268	0	241	353	16	311.30	39	79.10	CHANGED	lsshLlLsEshlshllIp+VPYTEIDWtAYMpplpuhLs.GppDYopLpGsTGPLVYPAuaVYIYouLYaLTstGsslhhAQhlFAslYllsLulVhhlY.ppt+lPPalhsLhsho.hRlHSIaVLRLFNDshAhLhLahul......hhhcp+.......WthGuhhaSlAVuVKMNlLLasPAl.LlLhLtshu.hltTl.pLsshullQlllGlPFLhpaPspYLppuFDLGRhF.a+WTVNaRFlscclF.s+pFplsLLhhHLhLLlsFsps+Ws..t......+h..plls.lhptt......hchpht........p..sssphhos...............................................hhsuNhIGlhhuRSLHYQFYsWYaaoLPYLlWpss...hshhlthllhslhEasWNsYPSTstSS	.......................h...hlhhh-hhlsh.hll.pVsY.......TEIDWpsYMpp.lphhls.G...phDYsplc..GsTGPLVYPAGaVYlaphLY.alT...s.p........G................p.............s...lhhAQhlFuhlYlhsLhl..Vh.hhY....p...p.............tp.............l...PP.a...h....hh.hhs.ho.hRlHSIaVLRLFNDshAh.hhha.hul...............hh.h...p.pp...........................Wh..hushha.....Shu..VulKMNlLLahPul..hhlh.lh.t......hu..hhtsl.hl.h.l.h................shl....Q.llluhPFL...h.........p.p...P...h...........s........YlppuF-huR.FhacWTVNW+FlsEch...............Fhs+tFtlsLLh.hHlhhLhhFhhhpWh.........................p..t..t.h.ht..lh.p.........................................tst.hh...h........................................................................hhsuNhIGlhhuRSLHYQFasWahaslPaLLats....................hs..hh..lt.hhlhhh.EhsWNsaPSTshSS.....................................	0	90	136	201
+1165	PF03561	Allantoicase		Allantoicase repeat	Finn RD, Yeats C	anon	Yeats C	Family	This family is found in pairs in Allantoicases, forming the majority of the protein. These  proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction: allantoate + H(2)0 =  (-)-ureidoglycolate + urea.	21.60	21.60	30.60	23.80	19.10	20.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.10	0.71	-4.75	13	1158	2012-10-03 19:46:52	2003-04-07 12:59:11	10	13	467	6	534	1098	1048	143.30	39	75.20	CHANGED	GGpVlusSDpaFuss-NLlpPucsh..........chhDGWETRR+Rp................GH.DWslI+LGss.GhIcuh-lDTsaFpGNasstlSl-Ashhpsps..........................scsspWsplLstpcht...PcpcHhat...lsspp.aTHlRLsIaPDGGluRlRlaG	.......................................................................GutslssoDpaF.u.s.spsl.LtPstuh..........phhD..GWETRR+Rp.....................sGa..DWsll+Luts...G......h.....Ict.l-lDTuaFpGNaPstsSlpAshhss...s..s..............................................................................................................sps.ttWpp.lls.p.sp.Lp......ss...p...c..Hha........t..............l......s......s......t.....p.......s....h......THlRlsla.....P.DGGluRLRlaG..............................	0	146	279	433
+1166	PF04864	Alliinase_C		Allinase	Mifsud W	anon	Pfam-B_4527 (release 7.6)	Domain	Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase (EC:4.4.1.4), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.28	0.70	-5.80	10	180	2012-10-02 18:26:03	2003-04-07 12:59:11	8	7	33	19	77	718	304	318.40	46	79.58	CHANGED	sDlssGDPhFLEcYWp++t-soAVllSGWHRMSYF..tsss.pFlSsEL-+pI+cLHclVGNAsT--RaIVFGTGoTQLlpAslaALSPs..ssssusPspVVAssPYYusa+cQTsaFcuptY+WcGsAusah....cssssssaIELVTSPNNPDGtLRcuVl...cGopu..IaDhAYYWPHYTPITtsuDEDIMLFThSKhTGHuGSRFGWALVKDccVAcKhlcYlptNohGVS+EoQLRsLKILK.llssh+sppGo....clFpFGacph+pRWcpLsclVspSs.RFSLQch.ss-YCNYFp+h+sPSPuYAWlKCEh-c-pDCtphL+.su+IhTpuGshFtussRYVRLSlI+opDDFD.hlpRLsshl	...........................................................................................................................shspGDshhhE.aWh.p.ptttuslllssWppMSYh...ss...............Flp.EL-+pI+c.LH..c.hV.GN.A.s.s.cs.+.alVh.GsGsTQLhpuh..lhu.LSPs...........ssu..sp.VVu.t..sPa..Y...s.......s.a...p.......p..........Q......T........c.......a........h........c.........p........t........h........Y.......p........W.....s....G.......s.....A....s...s.a..........s.s...s..s..s.ppa...I.E......h....V..T..SPNNP.....-G......h......l......R.....c........u.....V...l........cG...s..p....u..........Ia.....D.....hs..Y.......Y........W..........P......H.....Y........T.....P........I....s......t.........t.......A........D.........c....D.......I.....M..L.F...T...hS.Kh.TGHuGS...............RhG.WAL....l.KD...c..pVh..p..+...hh...p.Yhp..h..NT..G.sS.....+-oQLRuhKlL...+...tVsshhc.......s.............p......p..st..........cl.pFGacphccRWhplp.sllspS..c.RFSlpch.ps......pYCsaFp+hpsssP................ua..AWlKCEhE..-...s.cDChphhp.sst.I.spsG...at......s.ssc.aVRlShlcpp-sFs.hhthLt.h........................................................................................................................................	0	14	57	67
+1167	PF04030	ALO		D-arabinono-1,4-lactone oxidase 	Wood V, Finn RD	anon	Pfam-B_33547 (release 7.3);	Family	This domain is specific to D-arabinono-1,4-lactone oxidase EC:1.1.3.- , which is involved in the final step of the  D-erythroascorbic acid biosynthesis pathway [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.81	0.70	-4.80	34	1395	2012-10-02 00:48:38	2003-04-07 12:59:11	9	15	826	5	608	1305	206	200.00	21	43.75	CHANGED	lTlpslPuaslctppps.......hshppllcsh-phh..pps-ahchaWFPaocpshlhpsscssts...........sp.tpphhsphlsphhapsLhhlu.chhPslsPhlp+hshphhhu..........pptlssShcsFshsphh..p.h..EaulPhcpu.-sLpcLcshlspps.................hhlHaPlEVRhsssD......................................csaL..............SsshscsosYIssphYRshs.......hppaapthEslhpph.GGRPHWuKhaphsspp.............................lpphY.schccFhplRcchDPpshFls..sahc.+h	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................E.......a.......l..Ph.....p.......t....h.............t..............h..............l...p...pltthhptpt.........................h...hhs...l.phRhsts..s.......................................p...hL.................u..s.........t....p............s.....h.......hl.s.h...h..h.....t..s..t.................htp.hh..p....t.....h....-....p....h.........h....h.....c....a...u..G.......RP...HWu....K..........p..p..h..s.tpp...........................................................................................h..p...ph..Y....P...c.....h..pcFhtlRcc..h.DP..p..shFhs..sahcp.....................................................................................................	0	177	387	524
+1168	PF00128	Alpha-amylase	alpha-amylase; 	Alpha amylase, catalytic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Swissprot	Domain	Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the  active site, interrupted by a ~70 a.a. calcium-binding domain  protruding between beta strand 3 and alpha helix 3, and a  carboxyl-terminal Greek key beta-barrel domain.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.03	0.70	-5.03	31	28372	2012-10-03 05:44:19	2003-04-07 12:59:11	19	300	4623	473	6746	23482	3056	261.10	18	44.76	CHANGED	GDLpGIhpKL-..YLKc........LGlouIWloPlac.........Ss......u.HGYDhpDYpplsspaGTh-DhcpLlscsHp..+GlKlIlDhVsNHoSsppth...........Fpcuhpptss...hpcahh..h.h..........t.psssshht......h.stosaph......ppps.....h.hhhshsDLNhcNss.........lhpthhc....shcaWlcpG......lDGaRlDsspclsc............................sah+patpphsph.........thhhlGEhatss...sp.hhhhstsshhshs...hhsahphthtpssp.....hp.ss.s....htchpphlschhpthsp...sthtssalsNHDpsR.......hhothusst................ph+hshshlhshp.GsPhIYhGpEhGhoGsp.........DP	...............................................................................................................l.s....al.t.p........lGh.....stl.......l.....P..hhp......................................ss...........ts.h.G..Y..s........s..........h.......s.......a............h.........s.........l.........s.........s.........p.........a..............G..............s.........................p...........-...........h........c...........p...........h....l....pth.+p..........tG.......l...............p...l.l......hDh......Vh....N......H.h...u......t...p...p........h...................................................................................t........t.................t...h.......................................................................................................................h..t..............................................................................p.l..s....h....t....p............................................................hh.p...h..........h...p.......ht.a.h.h.p...h..................lc.Gh...R.....h.Dhh.t..h..h...........................................................................................................h..h.t....h...h..t....h.t...t.......................................h.hhh.u.E...h......t.............................................................................................................t.........................................t.....................................................................................................................h...........................................................................................................h.......t....s..H.D.................................................................................................................................................h.......h...h.......t.................................h...........................................................................................................................................................................................................................................	1	2088	4020	5641
+1169	PF02903	Alpha-amylase_N	alpha-amylase_N; 	Alpha amylase, N-terminal ig-like domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.20	21.20	21.50	21.30	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.77	0.71	-4.14	38	1507	2009-09-11 01:10:01	2003-04-07 12:59:11	9	20	1336	56	147	988	29	118.10	30	20.02	CHANGED	Mh.htAIaH+PpssaAYsYsppplHIRLRTcKsDlp.cVtLlauDsYph..................th.hpphsMcKhuos...plaDYW.splsssh+.R..l+YsFpLps.sscphhas-cG...hapctshs...hthaFpaPalp	......................................shaHhP.s...as...h...h...h...s...c...c.....p...LpIpLps.....p.p.p.D.l.s....c......lh.L.hhtcshp................................tshs...McKht..S.s..........sh..a..-..a..W....p..ssl..s..h..s...t..R...hpYsFcLhs..c....scphaas.spG.............hs...p..h.s.hc.................................................	1	45	79	112
+1170	PF02296	Alpha_adaptin_C		Alpha adaptin AP2, C-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_8859 (release 5.2)	Family	Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.	24.20	24.20	24.30	24.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.39	0.71	-4.12	21	349	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	230	11	231	333	4	109.80	43	12.10	CHANGED	FhcPspl.oupDFFpRWKQluusspEAQ+IFt..........uspshstshs+phl.pGFthulLpsVDPNscNhVuAullpop.uGp...lGCLLRLEPN.hpspMaRLTlRuoc-sVsptLhcl	..................FhpPsch.su.p-FFpRWKQLu.....ss...t..p.E..sQcIFp.............us+sh-....tp..h.s+s.tl....hGFuhslL...cs.V..DPNPp...N...hV.G.AGllpT...c......ssp........lGCLLRLEP....N...hpupMaRLTlRooc-.sVsptLsc...............	0	80	124	184
+1171	PF02883	Alpha_adaptinC2		Adaptin C-terminal domain	Bateman A, Griffiths-Jones SR, Mian N	anon	Pfam-B_8859 (release 5.2)	Domain	Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud  site.  This ig-fold domain is found in alpha, beta and gamma adaptins.	20.60	20.60	20.60	20.90	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.62	0.71	-3.77	102	1431	2012-10-03 16:25:20	2003-04-07 12:59:11	15	26	301	45	862	1378	12	109.40	19	13.69	CHANGED	ssshlapssslplthphph..........tpsshhplphhhsN...p.sspslsshshp..hulP.........pshplplpss.sssslss.......ssplpQhlhlts...........hph+l+lsaphs...up.th...p.t.h...hP	.....................................hhlapps.slp.lthphph............tpsshhhlhlphsN.......p..sspslsshshQ....hs..ss.............................cshplp.Lpss...sssplss..........ssplpQhhhlt.s.......................t...p..hplclsap.hs.st.......p.h........................................	1	253	405	648
+1172	PF00944	Peptidase_S3	Alpha_core; 	Alphavirus core protein 	Finn RD, Bateman A	anon	Pfam-B_266 (release 3.0)	Domain	Also known as coat protein C and capsid protein C. This makes the literature very confusing.  Alphaviruses consist of a nucleoprotein core, a lipid membrane which envelopes the core, and glycoprotein spikes protruding from the lipid membrane.	20.70	20.70	20.80	20.80	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.86	0.71	-4.81	5	862	2012-10-02 13:45:52	2003-04-07 12:59:11	14	3	54	46	0	511	4	104.80	71	12.60	CHANGED	sMKLEuD+TFPlhL.DGKVNGYAClVGGKVhKPLHVKGTIDNPsLAKLKFKKSSpYDLEaAcVPssMKSDAFpYToEKPEGFYNWHHGAVQYSNGRFTVP+GVGGKGDSGRPILDNoGKVVAIVLGGANEGuRTALSVVTWNcKGVTlKTTPEuoEpWS	...............................................................................................................GRFoVP+GVGuKGDSGRPILDNKGRVVAIVLGGsNEGSRTALSVVTWNpKGVTlKhTPEGoE.WS..........	0	0	0	0
+1173	PF01589	Alpha_E1_glycop		Alphavirus E1 glycoprotein	Bateman A	anon	Pfam-B_587 (release 4.1)	Family	E1 forms a heterodimer with E2 Pfam:PF00943.  The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus) [2].	25.00	25.00	25.30	27.00	18.20	24.60	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-12.88	0.70	-6.18	17	1920	2012-10-01 19:42:26	2003-04-07 12:59:11	11	5	59	57	0	941	0	247.60	48	50.15	CHANGED	.tu+Ats.hsEohsYLWspNQshFWhQhshPlAulllls.hlRsh.CCh...sFLllhu........ls.ssspAYEHssslPNhVGhP.YKAlV-RsGYuPLsLplpVlpopL.PolsLEYITCcYKTVVPSPhVKCCGssECss..........ppcsDYpC+VaTGVYPFMWGGAYCFCDoENTQhSEAYV-+S-sCptD..HAtAY+sHTASLKApl+loYGsss.psl-saVNG-ossphsshKhIhGPlSoAWoPFDsKlVVYKs-VYNhDFP.YGuGpPGpFGDIQuRTss...SsDLYANTsL+LtRPuuGslHVPYTQsPSGFchWhp-+GpsLspsAPFGCpIpsNPlRA.NCAVGsIPlSlDIPDAAFTRls-uPslopLpCpVssCTaSoDFGGlAslpYpo-+sGcCuVHSHSssAsLpEuslcVhp........sGphTlHFSTASspssFhVplCus+sTCpAcCcPPKDHIVsaPspHssthhsslSsTAhoWlptlhGGsusllslullllllVshlshpR	..........................................................................................................................................................................................................FMWG.................................................tt.s...h.sasNG.pssp.tt.phhhGPhSouaoPFDp..........................................................................................................................................................................................................................................................................................	0	0	0	0
+1174	PF00943	Alpha_E2_glycop		Alphavirus E2 glycoprotein	Finn RD, Bateman A	anon	Pfam-B_308 (release 3.0)	Family	E2 forms a heterodimer with E1.  The virus spikes are made up of 80 trimers of these heterodimers (sindbis virus) [3].	19.50	19.50	21.10	21.00	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.51	0.70	-5.84	23	2166	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	59	31	0	967	0	320.80	49	61.18	CHANGED	PYlAhCscCutGtsCaSPlAIEpVpu-AsDGhl+IQsSuQhGls.puGstctsKhRYhts...pclcEushsslpVpTSuPCpllushGaFlLA+CPPGDolTVuFp.sssss+uCplsa+hc.p.VGRE+ashsPpHGp-lP.....CssYspssppost..l-MH..hPsshsDpoLLSpsuGsVpls.PuG+slpYcCpC.GstpsGTs.oocpplssCsts.QC+AahsspsKW.aNSshlPR.usspshKGKlHVPFsLssuTCpVPLA.pPsVpauh+ploL+LHPc+PTLLThRpLGs-PphocEWIotsssRshsVsccGlEYsWGNpsPlRlWAQ.cousGsPHGaPHEIlpaYYphYPssTlsslsusuhllhluluuSshhhspARpcCLTPYsLTPsAtlP......hsLulLCC	.......PYlu+CssCtcu.sCaSPltIEcVhs-ucDGhlRIQTSu.aG.D.posptctp+hRYMss...hpltEu.hcplpVpTSuPCpllshpGYFlLs+CPPGDolTVuhh.pssshHSCTVth+Vphp.VGREpYpaPP.HGtplP.....CssYsphppsousY.lpMH..h.Gshs.oThLppppGpVhlssPuGpTVpY-CpC.uspp.GTT..upchplhhCccscQChAYlsspsKWVaNSscL.R.u.sscohKGKlHlPFsLssssChVshA.tPhVp.hh+tlhL+LpscpPTLLohRpLGt-sp.ptcWlpt.sphshoVstEGlEasWGN.sPhRhWuQ..os.GsPHGaPHEll.aYYphaPhhTlhslsshshhhhlshssohhhhspsRp.ClTPYtLsPsApVP......hhlulhCC.....	0	0	0	0
+1175	PF01563	Alpha_E3_glycop		Alphavirus E3 glycoprotein	Bateman A	anon	Pfam-B_285 (release 4.0)	Family	This protein is found in some alphaviruses as a virion associated spike protein [1].	25.00	25.00	67.70	67.70	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.83	0.72	-4.16	25	939	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	57	13	0	592	0	56.50	63	6.95	CHANGED	MClLANlTFPCspP...PsCY-+pPppTLchLEsNVDpPGY.pLLcAsl+Css..pRp+R	.MClLANlTFPCsQP...PlCYsRpPcpsLshLE-NsDsPuYDELLpusV+Csu..+RtKR....	0	0	0	0
+1176	PF03229	Alpha_GJ		Alphavirus glycoprotein J	Bateman A	anon	Pfam-B_3350 (release 6.5)	Family	\N	21.00	21.00	21.00	21.30	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.96	0.71	-3.79	5	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	8	0	3	47	0	92.70	53	76.17	CHANGED	MRSLLFVVGAWVAAlVTsLoPcAALATGsTsTsGsANu....sssssAoGANATSAsAuuThAAssssPPscST.sstTPGPaPPTDFALPLVIGGLCALTLAAMGAGALLHRCCRR.AARRRQRVSYVYA	...........................hu.ls...........................................................uslAATphuPAuso....TpAPsoPaPSPhus...FAl....PLVlGGLCAlVLuAhshhtLLRRsCRt.huR...........hs............	0	0	0	3
+1177	PF01120	Alpha_L_fucos		Alpha-L-fucosidase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.20	0.70	-5.55	48	2021	2012-10-03 05:44:19	2003-04-07 12:59:11	12	80	870	58	664	1863	422	324.50	24	62.37	CHANGED	hlllh.........hhhts...........spspapPsh-sls............ppt.pWFc-sKFGlFlHWGlYSVPuhs.....................sEW.......................hhpp..pthsstpYt........chs..........spFssp......pFDscpWsphhKpuGAKYhlhToKHH-GFshWcS.....chot.aNssc......ssPKRDlltELspAs+cp.Gl+hGh..YaS..hh.-Waps.a.htcppstht................phppa.............................................hp.hhhsQlpELlspY.ps-llWhDGsWtt.............................ssptWpt...schhshlhphpP...slllssRhtpss.tth..........sapss.EpthPsp..........l.ppsWEsChTl.ssoWGY...phpspsapospplIcpLlcsVSpGGNLLLNlGPps-GslsshtpcpLpphGpWhchNGEuIYu	.............................................................................hhhh.h.............................................................ap....p.....chGhhhHaG..sh..s.............................pW.......................................t.................ta.t...................................p...........p.tF.s..s..p........paDs..cpWschh+puGhKalllTsKHH..D.GFs....La..s..o..........p.ho.......s...asshs..........pss...+...p...Dllt..ElspAs+c.......t..GlchGl....YhS.......h...D.......h....p..p....s......a....hh..st.pt.........................................h...........................................................hp.hhhsQlpE.Ll...s.......p....Y...sp...h.s....hlWhDGs.hst.................................................stpth.ph..........pchh.phl..c.p.h.pP....................ssll......s......s......+hss.s......h....................................th.p..-..p........s.t.t...................................h...h..a......E..s..sh...o.....l....p.......suWhY.......................tpspph..K..ohppllc.h.hh...c.sVu.+s....us.l.LLNls.Pst.sGhlsstthptLtphGp.aht..............................................................................................................................................................	0	276	488	583
+1178	PF02232	Alpha_TIF		Alpha trans-inducing protein (Alpha-TIF) 	Bateman A, Mian N	anon	Pfam-B_1799 (release 5.2)	Family	Alpha-TIF, a virion protein (VP16), is involved in transcriptional activation of viral immediate early (IE) promoters (alpha genes). Specificity of Swiss:P23990 for IE genes is conferred by the  400 residue N-terminal, the 80 residue C-terminal is responsible for transcriptional activation [1].	25.00	25.00	191.50	191.30	18.40	17.60	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.14	0.70	-5.63	13	66	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	37	1	0	62	0	333.00	47	75.87	CHANGED	sssss+luhPP....PpsuuPssLYpRLlpELsFsEGPuLLutLEphNEDLFSClPtNtDLYpcstlLSssss-Vlcsspsssst....ssslsLssHGstshPpsPusc--LPsYVpulQpFFhuELRAREcsYs+LLhsYC+ALlcYL+usup+shRGht.ps.pstthpp+hRphltsRYYREsA+LARLLYLHLYLoloRElSWRLaApQstpQsVFsuL+acWtQtRQFpCLFpPlLFNHGlVhLEGcPLsutcLRclNYhRccLGLPLlRsuLlEEpsuPLsp.PsFoushPRosGaLsppIRuKh-uYSpt+sssPt.pspp-HsYu+thsss.NYGoTlEAhL.cPssP	.......s.pttphh.sP....PhsssPsuLapRLlc-LsFs-GPuLLotLEpWNEDLFSslPtNtDLYp-sthLSssss-Vlptsps.sst....tstlDLpsHGshshPpsPusc-sLPsYVpulpcFFhuELRAREEuYsplLssYC+ALh+YL+uou+cthRththps.pstshtcphRphIusRYYREsARLARlLaLHLYLsloRElSWRLaApQhhppslFssLph-WpptRQhsCLFpPllFNHGlVhlcGtPlpAtcLRclNYhRccLGLPLlRsuLlEEssuPLsp.PsFpushPRuuGaLhphIRuKh-uYSphtsspPp.tshpEHsYu+thsts.NYGSTlEuhL.sPss.s....................	0	0	0	0
+1179	PF02430	AMA-1		Apical membrane antigen 1	Mian N, Bateman A	anon	Pfam-B_2016 (release 5.4)	Family	Apical membrane antigen 1 (AMA-1) is a Plasmodium asexual blood-stage antigen. It has been suggested that positive selection operates on the AMA-1 gene in regions coding for antigenic sites [1].	20.10	20.10	38.70	21.90	17.70	18.30	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.96	0.70	-5.61	7	1565	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	33	38	37	1845	0	343.80	69	86.34	CHANGED	WpcaMtKaDIt+sHGSGIhVDLGEDApVtspsYRhPsGKCPVhGKuIhlpNus.sF.LoPluotstpl+ptGLAFPp.......................s-splSPlThssL+ph.YKcp......sDlu.CucaAushVPusspNopYRaPhVYDcpschCYlLYsuhQ.N.GsRYCssD..tsp.csuhhChpPtKscp.ppLsYhopslcpDW-psCPh+sl+sAhFGhWsD..GpC.sht.hhpcpucsh.-CspIlFptSASD.p.cphpcchsDhpclppGhpptNhphltpA.FhPluuhpucphKS+GhGhNWANYDscspKChIhsspPoCLI.spsalAhTALSSP.E.sthsaPCsIhKschhh.............................E.+tpspsht.ss.s........hP.clahS.cK-oLcCss.spphssuoCs.aalCssVEtct.lppsp.l.l...............hsp+phllIhlhhssuslllslhhhaha+.......+pcsu-.............cYD+ht	...............................................................+CPVFGKGIII....E....N.......S......s...TTF.LTPV..ATtsQcLK....D...GGFAFPP.........................TpPhh..SPMTLssM.Rc.h...YKDNc.V.....KNLDELTLCSRHA...GN...M.sP....DsD.......c...NSN...YK.YPAVYD-K-KKCHILYIAAQENNGP.RYCNKD..pSK..RNSMFCFRPAKD.cS.F.p.NYTYLSKNVV...c....N....WE...KsCP.RKNLpNAKFGL..WVD..GNCE-.I.Pa...Vp.E...h...pApDLhECN+lVF..ph..S..ASD.QPpQYEpchTDYpKIppGF+ppNtpMIKSA.FLPsGAFpuDpaKS+G+GaNWuNa..sp.....p..pKC.IFNsKPTCLINspsaIATTALSHP.E.V-.pFPCSlYKsEI.+.............................EIc+pS+php.L.ssDs...c+IlhP.RIFISsDh-SlKCPCtPEhlSNSTCp.FaVCpCVE+RAElppNNpVVl................p...........................................................................................................................................................................	0	13	17	33
+1180	PF03913	Amb_V_allergen		Amb V Allergen	Finn RD	anon	DOMO:DM04509;	Family	\N	25.00	25.00	66.90	66.60	21.60	20.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.72	0.72	-4.23	3	4	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	3	3	0	8	0	42.80	61	62.87	CHANGED	lssCYhAGolCGEKRuYCCSDPGRYCPWQVVCYES+cICuKNCu	..hsChhAGslCGEKRuYCCSDPGRYCPWQVVCYESpcICuKpCu	0	0	0	0
+1181	PF02948	Amelogenin		Amelogenin	Bateman A	anon	Pfam-B_402 (release 6.4)	Family	Amelogenins play a role in biomineralisation. They seem to regulate the  formation of crystallites during the secretory stage of tooth enamel development. thought to play a major role in the structural organisation and mineralisation of developing enamel. They are found in the extracellular matrix. Mutations in X-chromosomal amelogenin can cause Amelogenesis imperfecta [1].	21.00	21.00	21.00	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.51	0.71	-3.64	6	451	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	281	0	28	407	0	113.20	52	97.18	CHANGED	lPLPPHPpHPGYVNFSYE..............VLTPLKWYQShhpHQYPsYGYEPhGGWL+p.hlP.hsPQhPpQp....phhPpLsPHHplhhl.......PQpPhh.hPuHHPhhPh.tp...pPph......PsQcPlpPpssp.P....QPQQPspopPPhp.p.PhsPpss..........pPMaPlQPLPPhlPDhPLEPW.uADKTKQEElD	..........................................................................h+p..phhP..h........s.pa............hh.shHph..............P..Q.pPh.h.....PG..pps...hsPhptp....ps....hs.....PsQpPh.Q...Ppssp...P.........QPpQP.lp...P...p.Ph...HPhQPhsPp................P.haPhQ...PLPPhlPDhPLEuWP....................................	1	2	2	6
+1182	PF04709	AMH_N		Anti-Mullerian hormone, N terminal region	Kerrison ND	anon	DOMO:DM04835;	Family	Anti-Mullerian hormone, AMH is a signalling molecule involved in male and female sexual differentiation [1].  Defects in synthesis or action of AMH cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism [2]. This family represents the N terminal part of the protein, which is not thought to be essential for activity [2].\	 AMH contains a TGF-beta domain (Pfam:PF00019), at the C terminus.	19.60	19.60	20.10	20.00	19.40	17.50	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.36	0.70	-5.51	13	109	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	66	0	28	87	0	261.20	30	66.38	CHANGED	lpch.sAFlEul.pcuchsppDLspFGlCssuDssushs.Lp.Luphlscsttp..tLhVLHhpEVhW.......EsslpLpFphP...hsu..uss.s....sLLlhasGshts....ss.cVohousuL.PtsQSlClScDTpYLlLsscts..........puuhpsphhshs.p+ps-.GspLshs-LpthLhGscs+shTphTPlLLh............sus.hsucGplcssPhPps...........sPssT...............sFLspLpRFlRslLsP..pupsss.u.....LshsuLpoLPph.LsLSsotu.LtpLlsSppPolhlF.......sshsusLps.ppuphshpsuLlpcLtt+Lppstscl....Rshsuhsssss.hLpRLhsLssh....ssssuuuss....phRALLLLKALQoVpspWctcR	............................pth.tshhpsl..putht.ps.thFGhCss..tttsh...hp..ltt.ht....t..th.shH.tt.s.hh.......p....Lhhp.s....................hhLhh..s.........st.tl..htt..l....ttQslC.otsTpalhLsst.s..........tut....h...h..s.t...psp...tt..................h........ph...Lhstt.ts.hphpPhLLh................................ssph.hphhs.hs...................................ss.ps..........................FLppLpthlttlhs.......ptt............l..t.htshP...lshSpsts.Lttllpupt..lh.h........t..........s.ht...slhp.lh.cLptshhph....pt..s...sh...hht+Lhths............t...tssts..........hpuhLLLKALQslhttap.p.................................	2	1	3	9
+1183	PF01425	Amidase		Amidase	Bateman A	anon	Pfam-B_191 (release 2.1)	Family	\N	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.52	0.70	-5.63	44	12240	2009-01-15 18:05:59	2003-04-07 12:59:11	16	79	4062	116	4833	11144	9300	393.40	26	83.65	CHANGED	-llcthls+hpthppplsshhphhhppAhptApphcppht.......tssLtGlPlulKDslslp.GhsoTsGothhp..shhssh..DuslVcpL+puGAlllGKTNhsEhuhussspssha.........GsspNPashsc...ssGGSSGGuAAsVAushsshulGoDsGGSIRhPAuhCGlsGhK......PThGRluptGlh.....shssohDpsGshu+sVcDsulhhpsltGt-.tDssshs.............htt.httt.ptl+lGlhpp.h.......................................h.shsstlpcshppshttLpphG.tplhchphs.ht.hhs.hhhhhhssps.t......................h.chhsphp..s..phhsstlptpl.hsshshsth......hhpspph+t.hhpcphtphapp...............lDlllsPosstsshphsth..............t.sthhth.shs..ssssshsGhPulo......lPsuhs.pp.................GLPlGlQlhupthp-ptlL	.................................................................................................................hhpthhtph...t.....t...h......p............t.........l.p...s.....h...h..t........h....................p.....t...A..h.t...t....A.......p..t.h......-.......t..............t...........h...................................t.............t.........................................s.............s......L.t......GlP.lulKD...h.....s...s...............t.....G.....h..To.s.G..o......t...h.h..t.................s..h.....h...s.........s.h...........D...A....s..l..........V..pp.L........p....p........u........G............ul................h.l...........GKT.NhsEa.....u....h.....u..s.....s.....s..p...s..s..h..a....................................G.....s.p...N...P......a...........s.........h............s.......t....................ssG.G..SSu..Go..AA......A..V...............A..u.....s.............h..............s............s.h.....ulGoD...s.G..............G..S.....lR....PA.u...hsGl.........sG.hK.........Po......h..G......t..l....s....p...h...Ghh..................sh.s.s.s...h..-.....p.....h..G..P...hs..+...o......l...p...Dsu.hl...h.........p...s.l.............s.......u.......-.....s......t.....c.s.t..sh....................................h...........t................h.........t.....t.......s.........h..........p.........s...........h....+...l...u.l...p.p.hh................................................h....t..h...s...s...p...l.t...t.s..h.pp...s..h.p..h...L...p.p...h......G....t....p.............l........p.........h.....s.....h.......s..........h...p...........s......h.....t......hh...h.h....h..h.......s..-..st.t.t....................................................................h..p.h..h..h..t..t..p....s.........p.t...h....s..........t....h........p.......t....t...h.....h........h..u..t.....h..h...h.....s..s...t........................................h...hpu...t..ph...cp......hh...t..p..p..h.t.p..hhpp........................................h.D..hl..ls.Ps.s.s..t....s..s...th..s..t.....................................s.h...h....h...h.................h....h......s.......................h......h...s..h..s.......G...h.Pu.lo..............lP.s....uhs....p................................................................................Gh.P.l.G.lQlhu.t.hhp-ttl.............................................................................................................................................................................................................................................................................................	0	1337	2800	4004
+1184	PF01832	Glucosaminidase	Amidase_4; 	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	Bateman A	anon	Pfam-B_888 (release 4.0)	Family	This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J Swiss:P75942 that has been shown to hydrolyse peptidoglycan [1].	21.70	21.70	21.70	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.93	0.71	-4.05	162	6435	2012-10-03 00:09:25	2003-04-07 12:59:11	15	195	2899	3	744	3961	1635	133.40	25	32.41	CHANGED	htstApphtpc.hsl.s.slhlA..QAhLESuW......GpSt.....huppsp.NLFGIKut..........tst...htht.....TtEh.p.sth.phpspFRsYsohp-Shp-asp.hlpssst......Y...p..sshp..t..tpshpth....sptlpts.G....YA....T......D.PsYupKlhsll...pp.hsL	...............................h....h.phtpc.hs...l..s.shhlA..QAhLESua...........GpSp...........................hup.p.sp...NlFGlKu......................h.h...........................t.ch.s..spt.h.shtspa...+...t......a....sS.....hp.-u.lp.sasp..hlpps.t...................Y.........p..shhp....t.........ttshpps..........sttlppt.t...........YA.....T.................D..spYupc.lhsllppht............................................................................	0	222	434	613
+1185	PF02274	Amidinotransf		Amidinotransferase	Mian N, Bateman A	anon	Pfam-B_5784 (release 5.2) and Pfam-B_1850 (release 5.5)	Family	This family contains glycine (EC:2.1.4.1) and inosamine  (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively.  This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyse the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumour glycoprotein  [4] (Swiss:P16962).	22.00	22.00	22.00	22.00	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.74	0.70	-5.32	55	3546	2012-10-01 20:45:11	2003-04-07 12:59:11	12	9	2331	60	857	2617	1976	321.90	24	89.76	CHANGED	hhR.PsphthN.spostsshh.............sst.h.ppAhpEacshlptL+pp.GlcVhhlcch.t..................................................................................sshP-ulFspshhus....ts..uslslhPMhs.sRRpEpphshhhhhpp.....hth..hhchs.thc.psthLEG.Gshlhspppplshusts.Rosppslcphspphshp..shhhps...hssptpshhHhsshhslusphsllshsslhsst............................cphlhpt.......Lptss.hcl.Iplu.......tcphh.shuuNhLpl.....s......h..s.hAass.s.sppphhcp............tscllthslsplp.tGGGusRCMhstlah	......................................................................................................................................................hpPt..h.phh.s.hpphh...................ssh..lptA.p.c.EH-taspsL......+pp...G...l..c..Vhhlc.s.l.h.t.............................................................................................s.shPsh....h..F....sRDstsh..............ls....ss...l....slspM......h.t..sRppE....shhhp...hl...hphp.................................th.hhh...shp...t................ss............plEG.GDhlh..l...u...c.............s..h.....l.s.......h........G..........h........u.........p...R.Tst.pul-...............pl...sp..plhpp........h....p.......l............l...s.h.....th...s......p.......s...c......s........h............hHLDT..sh.o.hl..........-........h......c......p.........hs.h.a.s.t.lh.st...............................................hph.ltpt...................L.t...h...c..p...hpl...Ipsu...................................tcEta....s...u..sNsLsl................ssGsV...................................lsas..p..s.s..h....s..s.p..h.L.c..ct..............................................Gl..c..l..lt....ls......ss.ELs..+GtG...Gs+CMohsl.R..............................................................................................	0	307	557	719
+1186	PF01979	Amidohydro_1	Adenine_deam;	Amidohydrolase family	Bateman A	anon	Bateman A	Domain	This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate +  H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5]. 	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.00	0.70	-4.79	58	18418	2012-10-03 00:45:34	2003-04-07 12:59:11	15	103	4730	152	4606	25313	10133	289.10	14	66.61	CHANGED	hlhPGhI...DsHlHhhps..t..................................h.shtpshpphlpuGsTsstsh...tssss................................htchlts..s.ph...hthh..spsuhts.htphhhsts.......................................lchhpshtth.....thhsshstpsstthtpsthtstsphscc.....t.slhhshHhtpssss.....................................h..h.....................hh.h......sthphhhhshhls....p..th.......tsstlshpshusct............t...t...lspshhphhphhpp.tht....ht.t...s....................................hsstchlphsThssAcshGl.pphGslpsGchADlllhc	...............................................................................................................................................................................................................................................................................................................................................................................lhPGhl......Ds..H...h.H..h...h...t.s....h.......................................................................................................................................................t...s......h....t.........h...h....p..t...h...h.....t....s.G...s.....T.s....h.h.s.h......ts.............................................................................................................h...p.....h.h....t........t...t........................................h...................................h.....s...........h.........h.....................................................................................................................h.c.....h.h.p....t.h....t....t...h......................................................t....h.....h............s......h......s...........p.............s.........s......t..........s..........h.........h..........p.........s..........t..........h.........h......s................t......h......t.......h....s.......p......t...............................................t..............t....h......h....h...p.....h...c...h...t..p...s...t..tt..........................................................................................h..h.............................................................................................t...hhh...h................................t....t....h.....t.....h......h.h....h...s..h...hlp.........................p.........ph...t.h..........h................t.......t...........t......s..t......h...t......t...t.............h........s...........s.....t....p........................................................................................................................................................................h........t......p....s.....h.....h..........h....h....p.......h...h.p...t.........th..............................................................................................................................................................................................................hsht..p..h...l.t..h...s....o.h....s.s....A....p.......h...h......s.........h....................t.........p........h.......G......p....l.tsG.t.ADhllh.......................................................................................................................................................................................................................................................................	0	1418	2812	3769
+1187	PF04909	Amidohydro_2		Amidohydrolase	Bateman A	anon	Pfam-B_4687 (release 7.6)	Domain	These proteins are amidohydrolases that are related to Pfam:PF01979 [1].	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.72	0.70	-4.84	132	6287	2012-10-03 00:45:34	2003-04-07 12:59:11	9	30	2257	66	2486	6470	2429	284.10	13	85.76	CHANGED	lDsHtH...................................................................t.th...h.hthtsh..thh.hts.hsh.tts....shh....ttt.s..shspt............h..h.....tthh.p..t.s..sthhshsshs........t..p......shtphtcth......................................................tphshtG....................lp..ht..thtss...stth..............................................hhp..........thtch.s.l.....slt.la......................................................................hthtp.hhht.slh....ccaPp.......lplllsHhGhs..................htth..hthhtptsslah...chst...h........................h.ssh.t.....h.....htph...hphhs.s...-+llaGoD.....................aPhhsh.tts.hsthh.th.h.......................stptpcplhtsNAt+lath	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..................h.....................h.......t..h....s....p..............................h..h.......t..hh..t.......t...s.........s..t.h..h..s.h...s......s......h......s.....................t......t...................sh..tc.h.t..c....th..................................................................................t....p..h....u.....h.p..G...........................lp........l...........s.....t..h.......t.....s..h............t...s..tthh...............................................s.hhp..................................t.htc.h......s...h...........s.lh.lH.................................s......................................................................................................h.t.t..t..t....h..h...h..t...slh.........pc..a.Pp........lpl..l.......l....sHhGts....................................................ht.th..h..t.......h...h...t.....p.....h.....s.....s..l..a.h......c.hut..h....................................................................shh...h...t.....h...............h.t..th......h.p..t..h.u.............-.+...l.l....aGSD..........................................a.P...h....s..p.......h....tt....httht...th.h................................................stpt...tp..plhhpNAtclat........................................................................................................................................	0	680	1536	2082
+1188	PF00155	Aminotran_1_2	aminotran_1; aminotran_1_2; 	Aminotransferase class I and II	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.94	0.70	-5.51	48	52439	2012-10-02 18:26:03	2003-04-07 12:59:11	16	160	5588	558	14604	63947	26038	337.30	17	82.76	CHANGED	sphlsLussphths.....hhtshhcst.c..........htttpshptYhshpuhsphcptlA.....chht........t.......h..ptp.slhhsuGssushtshhhhh......h.suct.lllssPsassatpshchsssp.lhhhth.............pshplDhpslppslpp...............phllhssspNPsGsshshcplpplhphsppp.shhllsDEsYtshshut...t..s....................hhhlpst.p......hhlstohSKsh.GlsG.RlGhlhu.ss...................pllstlpphspshhs...sststthssshLsssthh........plpphtpcltpp+phlhstLtph.....shshhtsp.uuhashhshsst.................th.ph........................Lhpc.hslhlhshp..th........s.hhRlsh.sshospplcthhptl	..............................................................................................................................................................................t.................................................h.h.tt.h...........................................t..t...s...h...h...h...Y........s.....s.........t.....u........h............t.......L......c...p....s...l..u...........phht......................................................h.......h....p...s.p..........p..l...h...h.....s...s...G.....s..p......t....s.....l..t.....h....h....h....t...h..h.............................h..t....s.......u......-........t........l.....l.....l....s.......s......P.......s.....a.............s.......s......h..........h.....t...........s.........h............p.....h.......s.........u............s...........p..........h...........h....t...h..s....h.........................................t...h....t......h....c......h....p...t......l....p....p....t....l....p..p..................................................................p..h.l.......l.....l.s....s...s....p....N...P........o.............G........s.....s...........h....s.....h....p.......p....h..p...p....l......h....p.......h...........s.........p.........c.............h......s..........h..............h...........l..l................D......-....s...Y...s....p...h..s....h..s.tt......t..s.....................................................htt.h..s..t.t..p..................h.lh.h.s...o...h.......S......K.s......h...........u........h..........s....G.h...R..l......G...a..h..s...u...st.................................................pl.h...p.......t....l.......p.......p.....h....t.....p.......h....hh...............ss.h..s...t...h....s.......s....h..s...s.....l...p....s...s..t.......................................th.p.p..h..p....p.....t......h....t....p....p....p....p...h...h.......h..p...t....L.pph..........................................sh..p..h...h.....t....s......p......u.......u........h....h....h...h..h..t..h..s.tt.............................................................t.s...p..h..h..pt.......................................L..h.....p.....c...........s.....l.....h.......l...h..s..s....t....h.sh...............................tt..h.lR.lsh..........h.h...s...p...p.h.pthht...........................................................................................................................................................................................................................................	0	4349	8681	12025
+1189	PF00202	Aminotran_3	aminotran_3; 	Aminotransferase class-III	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.97	0.70	-5.59	18	23135	2012-10-02 18:26:03	2003-04-07 12:59:11	16	134	4515	255	6601	18830	12804	322.10	28	72.23	CHANGED	sls+ucGsalh.Dh-GpcYlDhhSuhussshGHsHPcllpAlppQtsplsass.tshspcshhpluccLsphh....st.sh-+lhhssoGoEAsEsAlKhA+...h....shsp+s....................cIluFpsuaHGRThuulSl.ssssth+phhtPhhssh........hhlPaschts...............t.......h..hhpphpsssl..AAlIlEP.lQGEGGhhhsssuaLptl+clCccaslLlIhDEVQTGhGRTGchFAt-a..hGlsP...Dlhshu.KuluGG.hPluAslsssclhpsh..psss.......HGsTasGNPlAsAluhusLcllpc-pllpsspchushLpptLp.pLpct..shltclRGt..GhhhulEhsc	.........................................................................................................................................h..t+ucG.shlh....D.h.-...G......p....c.....Y...l..Dh.h.u..u.h.u................s.h.s.h.G.H..s....+...P...p.l....s...p.....A..l.p....c.........Q..h....p........p..h..h..p..h....................s.h...........s...........s.......p...s......t....h....c..LA....cpLsphs.....................................sh....c.....c....l....h..h.s..s..S....G...oEA....sEsAlKlAR.......................................s......h...s...t.....+s.................................................................................p.l.l.sh..p.s.u.aHG....co...h.......u....s...l.......u........h.......s......s.......t.....s......s.......h.......p.......p.......h......h......t...s.....h...h..s..s.h..............................ht..s..s..hs.s..hht.....................................................................................................t..............h..h......t......h......t.......s....p...p...l.........AA..l.ll.EP..l.Q..G.......p..u.......G..h..h.....s....s..s.....s..aLp.........tl.......Rc.......l.................C...c................c..............a................s....hL.................L.....................IhDE...V.t....o......G..h....G...R....T....G.........p.....h.....a..........A..........h............p...p..................h...u.....l......p...P.................D....l...h....s..h...u...K.u.l........u..G.G...hP.lu.A.h.l..s..p....p........c..l..h..p..s...h....t.sss........................au.s.Ta..u.G...N....Pl.A..s.A....s...u...h..A...s...L.c..l.....l.........p....p........p......s.....l..h....p...p.......s.p......p....h.u....p....h....l...t.....p....t.....Lp.....pl.....t..p..........p.................s.......h.......l..t..c...l....R..uh......G..hhhulph..p...................................................................	0	1940	3976	5469
+1190	PF01063	Aminotran_4	AA_transferase_C4;aminotran_4; 	Aminotransferase class IV	Finn RD, Bateman A	anon	Pfam-B_607 (release 3.0)	Domain	The D-amino acid transferases (D-AAT) are required by bacteria to  catalyse the synthesis of D-glutamic acid and D-alanine, which are  essential constituents of bacterial cell wall and are the building block for other D-amino acids.  Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.	20.50	20.50	20.50	20.80	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.44	0.70	-4.89	78	10610	2009-01-15 18:05:59	2003-04-07 12:59:11	14	29	4578	127	2921	7879	6007	228.80	22	69.44	CHANGED	hhlcpHhpRLtposptl...........thshshpp..........lpphlpphl........cths...tpss.hl+lh..lsps.t.h........................thhhhtttts.phhhspphphs.tsh........................hsphKosshhtthh.ttctt.....t....uh-c..s.lhhsppGt...lsEustuNlh......................................hhcs...............sp....lhTPshsp...s.hLsGlsRptll.phstt..sh.....lp-pslshp-lt.puc.....phalssohtslhP...lpplsst.h...........t..ht.l....hpth	................................................................................................................................................h.cpHhpRLppS.uctl..............h.hs.h.s.h.c.p..........................................l.h.p..t..lpphl......................ptst...........hsss..hlR.h........l.h..t.s...s...s....t..h...u..ht.sstt....h................................sthhhh.h.th..t.s.h..p.h..h..h...s..p..t...h.p..h...s..s...ts.h......................................................hsthK.s.s..s...ph...s....ssl.hspptA......................tpp.......Ghs-........s..lhls....t..p.Gh...............lsEsussNl.F......................................hh....c..s.................................s.p..........lhT.Psh...ss...........s..lLsGI.TRp..sll..pl..Acp...h.....u..hp....................lp.E...c.p...l.s.....h.c....-Lh...pA..c................Esahsuos..s.....lsP.........ltp..l..p..ththt...............u.hh.t.h............................................................................	1	919	1864	2466
+1191	PF00266	Aminotran_5	aminotran_5; 	Aminotransferase class-V	Finn RD	anon	Prosite	Domain	This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.96	0.70	-5.72	45	23746	2012-10-02 18:26:03	2003-04-07 12:59:11	14	88	5192	153	7010	41460	18473	338.30	19	85.74	CHANGED	lYLDuAAToppPpsVl-uhpcaYpphtuNlHR..uhHshuppuopthEpsRcpVApalsAps.cEIlFTpGoTc.ulNLlAtuhttt.....lpsGDcIllophEHHANllPWpplucppGsplc..hl.slsspGpl-..lcpl.pphl...s.scT+lVulsalSNlhGs.lpPlpclsphs+p.t.GAlllVDuAQulsHhslDlpplssDFhuFSGHK.hhGPsGlGlLYs+cchLpph...Ph.hGGpMlpplsh.psts....apphPh+FE.AGTPsluuhlGLusAl-al.ppluhstlpp+pppLtphshppLts.lsslpl..hG.s...pppsulluFsl.pslcs....pDluphLcpp.GIAlRu..G++CA.....Phhthhsls.......ushRsS.hshYNTp--l-pl	.........................................................................................................................................ah...sus.s...h.s...t....l.h.p.t....h....t.......h..........t..................u..s..s.....p...........th.p...t.h..u....t........p....h...p.....p.....h..h......c.....p..u...R.p.....p.l..t.....p......h......l......s......s........p........s.............p........c......l.....l...a..s..p.....G.........u.T....p....u.h.........s.............h........s..............h..............t....s...h......................................................h...p.............t...........s........c..................c...............l..............l...........h.............s....t.........h....-.............+......h......u......s.....h.......................s......h..........p.....t......l..........t.........................p......t.....G........h........p.......l...p....................h.l......s.......s.....s.............t........s......u.......h.....l..s....................h.p.p..l.....p.t..t.l............................s...s......c.......s..........t.......l......l.....s.......l....s.....t..s....s.....s..................h...G....s....l....p.....s.....l..............t..........p.......l.........s..............p........h........s...........+................p......t.......s...........s...............h........h........h........l...D...........u............s..............p...........u............h...........u...........p...........h.............s...........l...........D..........l.........p...........p.........h..........s..........l.............D............h............h......s.......h......o..u........a.....K...h.....h......G....P.....t.....G.....l..........G.....h.l........h.s.....+........c....p......h.....h..........t..........p.....h.................t...s.........h........h......h......u..............u....t........................................................p.t.ts.........................................................h....c.....s.....G......T................s...h.....h.....s.......l........h......u........h..........s.....t.....A.....h......c.......hh......t..................p...........h................s.................h...................p................t.................h.............t...................t......+...t...p.............p..........l...t..............p..............h....h......h.......p........t...........l........p.....p......h.........s............t............h.....t...l...............................s.....................t........................t..................t.......p.......t..................s.......s.......h......h....s....h.....s......h......t......t......h...c.s...............................p..t....l...h....h....h....L...p...p.....t....s....l..t...lps........G....ptss..................................................................................sshRhS.h....h...s...t.plp..................................................................................................................................................................................................................	0	2396	4497	5949
+1192	PF02293	AmiS_UreI		AmiS/UreI family transporter	Bateman A	anon	Bateman A	Family	This family includes UreI and proton gated urea channel as well as putative amide transporters [1].	25.00	25.00	28.00	27.70	24.90	21.80	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.30	0.71	-4.60	24	489	2009-09-10 14:59:15	2003-04-07 12:59:11	10	1	261	0	51	381	6	180.40	56	94.65	CHANGED	Mh.GlsLLYVGAVLhlNGLhlLG+lss+ssulhNlFsGsLpllsshhhlhsu................s.ucstslhuuAsshLFuFTYLaVulNplhsh.Du+GLGWaSLFVAlsAlshuhhu.hsss..........tchhhulhWlhWulLWhhFFLlLuLt+.plpphsualsllpGlhTuhlPuaLhLsGha	....ML.GLlLLYVGhVLlsNGlstLsKVDsKSsAVMNhFVGGLSIlsNlllIsaS................hu..pchsoaYusATGLLFGFTYLYsAINahFGL.D....hRsYuWYSLFVAINslPuAILS..aoshh.......hscusWaAIIWLAWGVLWLTuFIENhLK.....h.sLG.KFTsaLAIlEGIlTAWIPAaLLFhp+W.............................	0	15	38	47
+1193	PF02461	AMO		Ammonia monooxygenase	Bateman A	anon	Pfam-B_2301 (release 5.4)	Family	Ammonia monooxygenase plays a key role in the nitrogen cycle and degrades a wide range of hydrocarbons and halogenated hydrocarbons.	24.40	24.40	24.40	26.10	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.88	0.70	-4.65	8	15067	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	915	12	14	15207	1	149.70	61	93.12	CHANGED	uAutSsh+S+AEAstssRThDalhLshLFhllLGuYHIHhMLThGDWDFWlDWKDRRhWPTVsPIVuVTFPAAAQuaFWE+FRLPFGAThsVLGLLlGEWlNRYhNFWGWTYFPINhVFPouLlPsALaLDlVLhLSpSallTAlVGuhGWGLLFYPuNWPIlAshH.PsEhpGhLMSLADlhGFpYVRTGTPEYIRMVE+GTLRTFGKDVVPVAAFFSGFVShLlYFlWWalGKWFSTs.+alpp	..........................................................................................................................................................FahWo....aYPINF.VhPS.oM..IPG.ALh.hDslLLLT.pNWhlTALl.GGuuF.GLL...F.Y.PGNWP.IFGPTHLPl..Vs.EGs..LLSlADYpGahYVRT..GTPEY.V.RlIEQ.GSLRTFGGHTTVIAAFFuAFhSMLhahlW.WYhGthasss..a...h....................	0	6	11	13
+1194	PF00909	Ammonium_transp		Ammonium Transporter Family	Finn RD, Bateman A	anon	Pfam-B_596 (release 3.0)	Family	\N	19.20	19.20	19.30	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	399	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.45	0.70	-6.00	25	6224	2009-01-15 18:05:59	2003-04-07 12:59:11	16	40	3496	34	2233	5420	6440	367.80	30	87.31	CHANGED	sahllsuuLVhaM.psGhuhhpuGhs+sKNslN..hhhhshhshsls..slhahhaGauluFGps....hsuhhGs..........hthshhshsssshsphh.............hhFQhsFAs.sssuIlSGulAERh+hsuallauslhssllYsshuHWlWs...........sGahsphssh..........DFAGusl.VHhsuGhuGLssAhllG.Rhs+h......pstshpsHslshshLGshlLWaGWaGFNuGSuhshsshsts.............sslsTshAuAsGulshhhhshlpp..GK...shltstsGslAGLVAI.TsusuhVs.PauAlllGllAGllshhuht....hLpp+l+lDDslsshslH...GhuGlhGslssGlFut.th................sshhtGss....t.LhhQlluhhsshsauhssshllhhllshhhs..LRlot-pEhhGlDhspH.u-suY	...............................................ahhh.sshLVhh..M...h.....s.......G.......hAh...h...uG.h.l.R..p.K.N.s..l..s.......hh..hp....shhshuls..sl........ha...h..h.h...G..aulu......F..ut......t.....................h.s......s..h.hGs................................................h.h..t......s...h............t.......s.......s...h......p..h.h................................h.h.hF....Q..h.hF.Ah.....l.ss...........u...l...l...s........Gu....hA...E..R...h.+..asshl.lFssl.hssl.lYsslua..h.lWu............................................s.G..a..l....s....p..h.Gsl..........................................................................DFAG....usV.VHhsu......G..hu......u....Lss..uh......h.....lG......t.Rh.shh.........................tpsh.....s...H.........s..l.sh.shl.Gs.h........l.L...W.hG...Wa.G.F.Nu...G..Ss.h.s.s...ssh.ush.........................shlsThlAs.Auus..l................s...h....h....h....h....p.....h...h...ht..................s.K......s.......s....hhs.hhsG.slAGLVu..........I.....T................su..s.u..............h.....ls....shuAlllGhl..u.G.hl.shhuhp..............................hlp...p.t....l.....p....h....DDsl.s.shulH......GlsGlh...Gs....l...h...sGlFustsh.......................................................h..h.h..h....st..........pl..h...h...Qlhu..h.h.hsh...s.ashls....shll....h.hllchh..............hs.......LR..l........s..p-p..E..h...G.lDhs.H.ut.s...................................................................	1	776	1422	1922
+1195	PF05145	AmoA		Putative ammonia monooxygenase	Bateman A	anon	COG3180	Family	This family are annotated by COGS as putative ammonia monooxygenase enzymes.	23.30	23.30	24.20	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.86	0.70	-5.38	8	1520	2012-10-02 17:14:55	2003-04-07 12:59:11	7	4	1297	0	296	1116	1205	282.70	30	90.48	CHANGED	aMlGsllAuIlsspht.hslphshhhh.......tsuQsIlGltIGtplosslltslhspaslllsssllTlLuuslhualh+RhupsshsTAhauohPGGuotMlslu.pchGAsptlVuhsQshRllaVshssPhlsphhlss.......ussshshhhs....lslthlslLhhsuhlsuhsuphL+hPuPaLLuslLluAlVphG......hslphtLPsahhuhuQhllGhsIGsphs+shhtptsRhhhtsllsslhhlhhushhAhllohLssl-hhohhLuhsPGGlsphulsAtuLp.h-suhVsAhQshRlLhlLhlssslh+ahp+hts	....................................hhGshlss.llhs.h.hh.....hpl....p....h....Ph.hh...........hu.sllGs.lutsho..sl.ltsltt........h......l.lhlh.l.hsll..u.....h.l.hu.a.l....h.h....+.h..........u.............t..l.s....h............t.......Tuhhus.PGu...hu.tMl.shA..p-h.s.A.sh..thVuhhQhlRllhVshh.ssh.ls..th.h..hss..................................t..ss.s...t..h..h..hhs......................hsh.t.......l....llhh..l..h..u....h..l.u.u.h.h.....up...hl+.....lPusthLsPhl.s.su.l.h.phs.......thl.s.h.p..L..P...p...a.L.l.shA.hhlGhpIG.l..ta.s+th.hht..th.Rhlsth.llshh.hL..l.hh.sshhuhhlshhh.p..l.shhssaLusuPGGlsplsllA..hsss..ADhuhlhuhQslRlhhlLhh...s...P...sl.h+hh.p...s.....................	0	74	166	237
+1196	PF04896	AmoC		Ammonia monooxygenase/methane monooxygenase, subunit C	Mifsud W	anon	Pfam-B_6611 (release 7.6)	Family	Ammonia monooxygenase plays a key role in the nitrogen cycle and degrades a wide range of hydrocarbons and halogenated hydrocarbons. This family represents the AmoC subunit. It also includes the particulate methane monooxygenase subunit PmoC from methanotrophic bacteria [1,2].	25.00	25.00	34.70	34.70	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.61	0.70	-5.35	9	127	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	57	12	24	127	22	191.30	46	94.37	CHANGED	sspssususA.hsps.laDh+hhhlGlhshhsFYlhlRhYEpsaGaptGLDSFuPEFppYWMslhahEhslEhlssLslhGaLWKTRD..cslsslsPREElRRhFhhlhWLsVYuhAlYWGASaFTEQDGoWHQTlIRDTDFTPSHIlEFYhSYPlYIIhGVuuFhYA+TRLPhFu.KGhSlsaLhhhsGPFMIhPNVGLNEWGHTFWFMEELFsAPLHWGFVhFGWhuLuVhGVslQllsRhpcLh.sh-hsts....c	.................................h.s...hhhshhhh.hhhhhh.hYpthauht..tGhD.htPtapphWhshhhhph.l..h.h.hhhualhho.Rc.....cph.slsPp..El+Rhh..hhhalshYhhu.laauuSaFsE.QDuoWHQsllRDTsFTPSHll.FYhSaPhalhhGhushhYAhTRlPh.at...cuhshshhhhlhGPhMlhPNVGlNEWGHsFWFMEELFsAPLHWGFVhaGWsu.LuhhGlhhQhlschspLh.ch......h............	0	12	19	23
+1197	PF03782	AMOP		AMOP domain	Bateman A	anon	[1]	Domain	This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges [1].	25.00	25.00	25.60	26.20	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.45	0.71	-4.21	15	277	2009-01-15 18:05:59	2003-04-07 12:59:11	12	32	81	0	184	274	0	146.50	32	15.41	CHANGED	hspspC.cWlpsc.chL.sah....p-LPo...CPCohsQuhhDp.........uRFhs.hcsst..+pphshapPGAhaClRS..sspuSst.Gu.................QpCCYDssGpLh.....................sRG+shGsPshhps.hsPtL.paphDlhPahhC........Chas-p.uh.Ctha.hcR	......................................shspCppWhppc.....chL.p.ah.....p-Lss...C..PC....ohspshhDp..........uRhh..hssst...........ppphs.h...apsuAh.a.ClRS.....hpuosh..uu...................QpCCYcssGpLl.....................sRG+s.hGsPshhps......h....sPtL.Ha.hhDllPahhC...............shhs.....s..pp...Cp....c...................................	0	57	70	120
+1198	PF04739	AMPKBI		5'-AMP-activated protein kinase beta subunit, interation domain	Kerrison ND	anon	DOMO:DM04946;	Family	This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex [1]. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known [2].  The isoamylase N-terminal domain (Pfam:PF02922) is sometimes found in proteins belonging to this family.	21.50	21.50	22.20	21.50	19.70	18.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.39	0.72	-4.15	56	516	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	289	36	306	507	2	114.60	35	32.87	CHANGED	........tsP....tpas...splPsh..p.............................pph.pPPtLPPaLppsl........LNp.ss................................................................................ppc-.........sshL.....shPsHVlLNHLhspu..I+ss..VlslusTpRY+pKaVTpl......lYpPh	....................................................................................................ts...............................................................spcphpsPPhLPPaL.hpsl........LNpsss......................................................................................................................................................................hps-..............sulL.P.PNHVhLNHLastS...IKcu..VhslusTpRY+pKYVTslLYKP............................................	0	85	165	252
+1199	PF02166	Androgen_recep		Androgen receptor	Mian N, Bateman A	anon	IPR001103	Family	\N	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.48	0.70	-5.61	3	248	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	130	3	28	232	0	263.10	50	56.51	CHANGED	GLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGAsL.......QQQQE.............TSPRQQQQQQpGEDGSPQAHpRGPTGYLALDEEQQPSQQQSALECHPESGCVPEPGAAsAASKGLPQQPPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEAGTMQLLQQQQQE.................AVSEGSSSGRAREAoGAPTSSKDSYLGGTSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGGPPAVRPTPCAPLAECKGSLLDDSAGKGTEETAEYSPFKGGYTKGLEGESLGCSGSSEAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGGGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGP	...........................................................................................................pEslQsPusppsps.s.shAPPuspL.................Qp.....tp....................................pp.....pp....p.............QQ........s-ssSsps..Ru.suYLsL-ccp..p..su.....................................................................................................................p....................................................s......t......s....s.RsREssuss.S...SKDsalG......us..oTISDoAKELCKAVSVShGLuhE..........u........E......t.t...........s..s..c.t.........pt-pha.s................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	3	7
+1200	PF03139	AnfG_VnfG		Vanadium/alternative nitrogenase delta subunit	Mifsud W	anon	Pfam-B_1227 (release 6.5)	Family	The nitrogenase complex EC:1.18.6.1 catalyses the conversion of molecular nitrogen to ammonia (nitrogen fixation) as follows: 8 reduced ferredoxin + 8 H(+) + N(2) + 16 ATP <=> 8 oxidised ferredoxin + 2 NH(3) + 16 ADP + 16 phosphate. The complex is hexameric, consisting of 2 alpha, 2 beta, and 2 delta subunits. This family represents the delta subunit of a group of nitrogenases that do not utilise molybdenum (Mo) as a cofactor, but instead use either vanadium (V nitrogenases), or iron (alternative nitrogenases). V nitrogenases are encoded by vnf operons, and alternative nitrogenases by anf operons. The delta subunits are VnfG and AnfG, respectively.	20.50	20.50	21.40	115.70	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.35	0.71	-4.28	20	108	2009-09-11 14:59:01	2003-04-07 12:59:11	10	2	80	0	25	83	0	111.80	49	82.15	CHANGED	hcs+l-pLhDYIhKpCLWQFaSRuWDREcQNEGILsKTtplLsGEsscpsTP.tDRsYasDAlsLAcsaKp+aPWlsshsK-EI+pLhpuLKpRlDalTITGSLNpELTcppY	...ps+lDpLhDYI.cpCLWQFaSRoWDREcp.EGlLspsscLLsGE.s..huTP.pDRhaasDAlslAsDh+c+aPWhsphsK-EIptLhpGLKsRlshlTITuSLNcELscchY.	1	9	18	20
+1201	PF00212	ANP		Atrial natriuretic peptide	Finn RD	anon	Prosite	Family	\N	21.20	21.20	21.90	24.30	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.78	0.72	-3.87	39	340	2009-09-10 22:47:03	2003-04-07 12:59:11	13	3	149	7	90	346	0	32.00	49	25.16	CHANGED	phhpstcps+..h....sGCFGt+lDRIGShSGLGC	................s......tts+.phhs....sGCFGh+lDRIGohSGLGC.....	0	3	11	36
+1202	PF03452	Anp1		Anp1	Finn RD	anon	Pfam-B_4441 (release 6.6)	Family	The members of this family (Anp1, Van1 and Mnn9) are membrane proteins required for proper Golgi function. These proteins co-localise within the cis Golgi, and that they are physically associated in two distinct  complexes[1].	28.80	28.80	28.80	29.00	28.50	28.60	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.77	0.70	-5.25	49	428	2012-10-03 05:28:31	2003-04-07 12:59:11	9	10	142	0	314	409	3	260.40	42	61.82	CHANGED	phstsslpa..YDLsphpuos..cuhtpcE+VLIloPL...upa.....lshaacsLhpL.TYP..HcLI-LuFllscop..DsshptLtptlpclQ.................................................p.ts..tpppFtplpIlcpDFsphl..uQshp-RHuhpsQt.RRchMA+ARNhLlhssLpPtpSWVhWhDuDI...csPsolIpDLhpHs+DVlVPNVap.h.s..s.....s.pPYDhNSWh......ES-puLcL.AssLs-D-lI...VEGYA.EasTaRshhAahtD..spGsscpphpLDGVGGsulLsKAcVaRs..GuhFPuFs	................................slphaDLsphpuos..puhp....p.cE+lLlloPL+s.uupa........LshaFs...pLhpL...TYP..HcLI-LuFLVuDop..DsThshLpptlpclQ..................................................p...ts...pptFtplo.Il....c+.DFsth.......l......uQshp-RHu..htsQs.RR+hMA+ARN.aLL.ssLc.....P.tcSWVhWhDsDl...psPso.llpDL...hp.....Hs..KD....llVPN.....lap.h..s..s.....stpPYDhNSWh......ES-pulpL.ApsL.sc..Dsll...VE.G.Ys.Eas...T.a........Rsh.hAah..t...D...spussctEh-LDGVGGsulLsKAcVaRs..GshFPsFs...........................	0	61	156	266
+1203	PF03374	ANT		Phage antirepressor protein KilAC domain	Mifsud W	anon	Pfam-B_3485 (release 6.6)	Family	This domain was called the KilAC domain by Iyer and colleagues [2].	24.80	24.80	24.80	24.90	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-9.94	0.71	-4.02	66	1631	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1146	0	193	1289	13	109.40	28	45.26	CHANGED	Lc...pp.....ltttpPKspahDtlssus.ssltlsplAKhl.......slu..tpcLhpaLp-.pshlh+...sssphhshQct.hctGhhphKpsshtpss.Gp.cht...hss+hTsKGp....talhphlhppshht	...........................ppp..ltt.tPKstasDtlhpu.....p...sslhlsphAKhl...................slu.tpcLhpaL+c.....pshlh+.....ssp............p.......hPhp.ch...hspGhF.pl..K..ps..shs....p...ss...Gt.hp.hs...........hs.s+lTsKGp....talhphhhptt..h...........................................................	0	53	133	161
+1204	PF04715	Anth_synt_I_N		Anthranilate synthase component I, N terminal region	Kerrison ND	anon	DOMO:DM04829;	Family	Anthranilate synthase (EC:4.1.3.27) catalyses the first step in the  biosynthesis of tryptophan.  Component I catalyses the formation of  anthranilate using ammonia and chorismate.  The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family  (Pfam:PF00425). This region is involved in feedback inhibition by tryptophan [1].  This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-11.08	0.71	-4.17	111	5751	2009-01-15 18:05:59	2003-04-07 12:59:11	8	30	3830	10	1512	4547	2202	145.90	22	28.89	CHANGED	shhsPlshatplts...pt.......shlLESs.....t..ssp......uR.aShluhsP.........................ht....hpssththtt..........................tt.....p......................shph......Lcphhsphp.h.............t..P..FtGGhlGYhuYDh...hctlc.ph...........sshs.hP-.hthhhh..-phllaDHhppphhl	........................................................................................................sshthatp.Lpt.............tt.............hshLLESs...................t.........stp................uR.aS.llsh...ss......hhp.....................lp...........stspp.splpt............................................................tptph.ppts......................shph...............Lc.p.hh.p.p.hp.....................................t..s....F.sG.GhlGhhuYDh..................lpthE..pLs....p..........htsc.t..hP..D..hthhlh...-plllhDHhcpphh...........................	0	477	968	1295
+1205	PF03497	Anthrax_toxA		Anthrax toxin LF subunit	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	28.20	27.20	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.92	0.71	-4.44	7	96	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	91	65	11	94	0	173.00	35	16.76	CHANGED	t+sh.....s.tshctsGlssE..ascuhtplAcEpNshlhhRsVN.huToLIcpGh.uTKGhsl+uKSSDWGPp..AGaIPhDtphSK.......htsssttlp+hs.tsppul........tutuhsplsLplscpRlsELppsGshshstcsht....hshphssupphEFclppssss.atl.hhth.ss....lpVhGsshsht	..............ps.t.hctsGlssE..aupshpplApchNslIGlRsVs.lupoLIcpGh.soKGhplKuKSSsWGPp..AGFIshDQphSK.......hsssthplp+hNhpstKul........pttuhsplsLpIo+pRlsELhcs.s.lshhtcph..........hssptsss.pp...hEF...c..lp..p...p..sp...s.h..l.hhsppsp.....lpVhsss.p..s..................................................................	0	4	8	11
+1207	PF02522	Antibiotic_NAT		Aminoglycoside 3-N-acetyltransferase	Bashton M, Bateman A	anon	Pfam-B_1432 (release 5.4)	Family	This family consists of bacterial aminoglycoside 3-N-acetyltransferases EC:2.3.1.81, these catalyse the reaction: Acetyl-Co + a 2-deoxystreptamine antibiotic <=> CoA + N3'-acetyl-2-deoxystreptamine antibiotic.\	     The enzyme can use a range of antibiotics with 2-deoxystreptamine rings as acceptor for its acetyltransferase activity, this inactivates and confers resistance to gentamicin, kanamycin, tobramycin, neomycin and apramycin amongst others.	25.00	25.00	26.70	26.60	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.32	0.70	-5.11	52	757	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	561	30	138	557	210	200.70	28	82.97	CHANGED	hVHuSlpslGhlsGGsp......sllpALh-slu.pGTllhPstoss.ssst............t..t.h+tphPsaDPsho.so.cshGhlsEhhRphPushRSsHPthShuAhGtpAptl.hsspshs.saGtpSPLu+lh..chsGplLhLGssh-ssThlHhAEthushstcphtphp.....slh.tsGpph.Wpphpchshss.........pt......Ftplupsh.pppsh..hppuplGsAp.spLhst+-hlchuhp.alppc	.........................................hVHsslpphG...h.l..sus.......sllpulhcsls.pG.TllhPs.o.p.spst.............................saD.tho..o...shGhlsEhhRp.hs.s..shRSsHPhhShuAhGtpuc..l.h..c...th.s..........shGcpSPhtplh..c.hsupllhlG.s.s..h.p.ss.T.h.lHhuEtp..hs......hchhptht.......slh..ppGphh..hpph..pphs.hst.............-t.............h.plst.....h...pppt..............hppsplusut.hpl..h.ptpchlchshphhpt................................................................................	0	48	95	117
+1208	PF03230	Antirestrict		Antirestriction protein	Bateman A	anon	Pfam-B_3190 (release 6.5)	Family	This family includes various protein that are involved in antirestriction. The ArdB protein Swiss:Q47057 efficiently inhibits restriction by members of the three known families of type I systems of E. coli [1].	25.00	25.00	25.00	26.50	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.15	0.72	-4.00	27	1097	2009-09-10 21:28:14	2003-04-07 12:59:11	8	3	438	3	52	624	10	95.40	57	64.17	CHANGED	Lss.cYsGGaWpFYpLusGGhaM.APss....ppchplhssh.NGapGplSA-AAGIlsoLashu+h...utcsp....sDthhcpYapLR-aA..tpHsEuusIapAID	......................LC--YsGGhWshYTLsN..G................G.AFM.AP-s....s-sahLFNuh.NGN.cAEhSsEAAGIsACLhsYS...H+.....As+TE..................saAMos....HYY+LRDYA..LpH.....P..ECuAIhRlID...................	0	2	13	38
+1209	PF03589	Antiterm		Antitermination protein	Griffiths-Jones SR	anon	PRODOM	Domain	\N	21.60	21.60	21.90	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-10.19	0.72	-3.90	21	1401	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	423	0	52	693	1	94.20	30	76.57	CHANGED	ss..losuspsssucu.......sAlshtpoctp.Ghsla.....suttGhschssppAhctlhphs.slspps.hh+phcshhcshVhpshtp.uaA-hshut	...................p.s.lossspsspucu.......sAhshspoctt.Ghsla.....CuthGhSp.ssptAhptltphs.slsshs.hh+plps.hcshVhphhtp.AaADhphsA.........................	0	2	8	26
+1210	PF01786	AOX		Alternative oxidase	Bashton M, Bateman A	anon	Pfam-B_1154 (release 4.2)	Family	The alternative oxidase is used as a second terminal oxidase  in the mitochondria, electrons are transfered directly from reduced ubiquinol to oxygen forming water [2]. This is not coupled to ATP synthesis and is not inhibited by cyanide, this pathway is a single step process [1]. In rice the transcript levels of the alternative oxidase are increased by low temperature [1].	22.50	22.50	27.10	26.80	22.30	22.10	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.23	0.70	-4.92	60	637	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	343	0	287	637	966	195.30	41	67.21	CHANGED	ssaspcphp.slphtH+pspshuD+lAhhhl+hlRhshDhhohh....................................................................................................hocc+ahsRhlhLEolAGVPGMVuGhlRHL+S......LRthcRDt...............................................................GWIcoLLEEA.NERMHLLTFlcls.cPuhahRhhlhsuQGVFaNhaFlsYLlSPRhsHRFVGYLEEEAVpTYT+hlc-l-s.G+.l..h...shsAPpIAlcYWphsc.p......................................................................................................soh+DllhhlRADEA+H..R.-VNHThus	......................................................................................................................t.H.p.stph.DphAhhhl.c....hlRh.h.Dh........................................................................................................h.h.p....p+a.h.pRhhhLETVAuVPGMVu......G...hlhHL+S......LRphc+..s.s.....................................................................G.W..I..+.sL.L-EA.NERMHLhTFh.c.lu....pPt......WapRhllhssQG..VFaNsa..FlhYLlSP+h.uHR.hVGYLEEEAlpoYTchlc-.l-p...Gp.l........shsAPtIAl.........pYWphsp.p......................................................................................................ssl+DllhslRADEAcH...R...clNHhhus.......................	0	104	194	247
+1211	PF01261	AP_endonuc_2	AP_endonulease2; 	Xylose isomerase-like TIM barrel	Finn RD, Bateman A, Studholme DJ	anon	Prosite & Pfam-B_3980 (Release 7.5)	Domain	This TIM alpha/beta barrel structure is found in xylose isomerase (Swiss:P19148) and in endonuclease IV (Swiss:P12638, EC:3.1.21.2).  This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae [1].	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.09	0.70	-11.13	0.70	-5.05	311	17202	2012-10-03 05:58:16	2003-04-07 12:59:11	19	48	4117	343	4623	13647	4257	209.50	15	68.04	CHANGED	lpts...tphG..asslElhht..tth.........................hpplpphhcctulp......................h..hth.......................................ttt........hpthpptlchu...ppl..............G..sph.......lshhsu.............................................................h.ttstp....pshpphhc..slpplschst..ptG....lp.lslEshstpth..h.......................pchhpllcplsptt...ltlthDssHhhht.................ttshhphlcphssp...............lttlHl..pDs..................................ttspch..GpG.pl	..................................................................................................................................................................................................t.stphG.hps.lc.h..h...h...........th...................................................................hp.ph.t.phh.p.pt....s..lp.............................................l.....s..h..s...h...h.t...hhh..................................................t..........t.t..hp.t.h....p.p..s..l...ch.u.......p.tL............................G...s..ph.............l..s..hh.su...........................................................................................................h.ht.t.s.p...................psh.pp.h.h..c....sl.p..t.h.s.c.h....h....t...ptG....................lp...lslE.s.....h.ss..t.h.h..tth..........................pph...h..p..l...l...c.....t......l....s.........p............t.......p........lt...l...t...h.....Ds....sHh.hht........................................tts...h..t...p....h...l......p.....p..h.t..st..................l.ttlHl.....pDs........................................t....t...h...GpG.................................................................................................	0	1580	3025	3904
+1212	PF01636	APH		Phosphotransferase enzyme family	Bashton M, Bateman A	anon	Pfam-B_840 (release 4.1)	Family	This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides they include: aminoglycoside 3'-phosphotransferase or kanamycin kinase / neomycin-kanamycin phosphotransferase and streptomycin 3''-kinase or streptomycin 3''-phosphotransferase. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation [2]. This family also includes homoserine kinase. This family is related to fructosamine kinase Pfam:PF03881.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.76	0.70	-4.64	244	16611	2012-10-02 22:05:25	2003-04-07 12:59:11	18	143	4228	100	5858	21791	6494	227.30	12	63.11	CHANGED	phphhs.sG.hsst.sahht........ssp...t........phl.......l.+h........................hpss......htph.t.....tph.p............hh..phLs.ppth....s..........sPps...l........s....t...tthtth......................hhthh..phlsGpthtp.................t.tthhp..thuphLs....................................plHph.....................t...........................ttshs..................................................tht..t..........hht......h.h......................pth.hph.............th........ht.phhp.........phhp...............................hhsthtpths...................hslh.HuD.hpssNllhs.............tsspl...ullDa....ppushus.hhDl......uh..h..h.......t.hs.ths...................sphhtth....hptht.............hshtphphh	...........................................................................................................................................................................................................................................................................................................t....................h...h.....................................t..............ph.h.......h.+h...............................................th..................t.h..t.....................................hh.......th....l.t...t.t.th.......................................................s..P.p.h....h...............................t..................t...hh...........................................................hhlh....p..h..l..t....G.p...htt..................................t......t.h...h.p........th...s...p..hl.t...........................................................................................................p.l.+p....h.....................................................................t............................................................................h.t...........................................................................................................................................................................tht........t........................h...............................................................................t.h....ph...............................th.................ht..th.t...................t...hhp......................................................................................h..h..p.t.h..t..p..t..h.....................................................ths.h.h...H...u..D..h.p............s.Nl.l.hs...........................tss..p....l....s...l....l..D....a.........p.t.s..s....h....u....s......h....h......D.l.................uh...hh...................................................................................................hh............................................................................................................................................................................................................................	0	1538	3487	4810
+1213	PF02558	ApbA		Ketopantoate reductase PanE/ApbA	Bashton M, Bateman A	anon	COGs	Family	This is a family of 2-dehydropantoate 2-reductases also known as  ketopantoate reductases, EC:1.1.1.169.  The reaction catalysed by this  enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway [2].  ApbA and PanE are allelic [2].  ApbA, the ketopantoate reductase enzyme is required for  the synthesis of thiamine via the APB biosynthetic pathway [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.78	0.71	-4.77	98	4828	2012-10-10 17:06:42	2003-04-07 12:59:11	11	38	2913	28	1377	9328	3628	147.80	22	45.49	CHANGED	ItllGuGAlGuhhustL..tp.uGpc.....VphlsRsp.phpt.lpppGlplpssp........tphhh.s.hthsss.............htthDllllssKuhpsps.slpt.ltshlsss...s......hllhlQNG...lGpt.-tlpphh.....st..p.pllhGlsh.huutpps.......supl....pps...u..tuphhlGthss	....................................................................lsll.G.s.G.A.l.G.s.hh.u.s....tL.....tp....u....Gp-..........................Vsh......l..s..R..t....s....p...hps....l..p....p..p.....G..l.p.lptts..........tphh.h........h.thsst............................................hsthD..ll.l.l.......s.......s.......K....u........h..........p........l.....s.....s.....s.lpp...l...t..s..h..l..sss...o.................hl...l..h.....l....pN..G.....................h..up...........-t.lt..phh........................................st....p..pllhGs.sh...hs.uthps.......................ss.tl....hhh....u...tsth.ls....s.......................................................................................................................................	0	390	813	1149
+1214	PF03256	APC10		Anaphase-promoting complex, subunit 10 (APC10)	Mifsud W	anon	Pfam-B_4273 (release 6.5)	Family	\N	19.90	19.90	20.10	20.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.18	0.71	-4.72	7	646	2012-10-03 19:46:52	2003-04-07 12:59:11	11	56	294	3	429	618	4	165.50	26	13.97	CHANGED	.ptsssssu.t..pphphtGh........hh-luppAhWolSSsK.G.GVc.hLRD-sh-TaWQSDGu.PHhlpIpFpK+sslphlslYhsaphDESYoPSplplcuGsshpDhp.lphh-lsp..PsGWVplslp...................Dspt..p.l+shhlQltlhsNHpsG+DoHhRtI+lYuP..p..t.shp.hht.....oohth.phsol	.......................................tt..tt............................................h...t..So...p......t.slt.....pL........pDssscoYWQS...DG...s................p...............s...H.hls.lphp.+.t..s...h.l....pplt..lhls.ptDcSY....hPs+.lslhuGsshs.s.....L.p................E........l..ps.....lpl.p...............ssGah.pl.l.................................................................................p.s...s....p.hph.hlQltlhps..pps....GhDT+lRtlclhu....................................hh..................................................	0	128	193	305
+1215	PF04110	APG12		Ubiquitin-like autophagy protein Apg12 	Wood V, Finn RD, Bateman A	anon	Pfam-B_9471 (release 7.3);	Family	In yeast, 15 Apg proteins coordinate the formation of autophagosomes.  Autophagy is a bulk degradation process induced by starvation in eukaryotic cells [1]. The Apg12 system is one of the ubiquitin-like protein conjugation systems conserved in eukaryotes. It was first discovered in yeast during systematic analyses of the apg mutants defective in autophagy. Covalent attachment of Apg12-Apg5 is essential for autophagy [2,3,4].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.89	0.72	-3.79	6	282	2012-10-03 10:59:06	2003-04-07 12:59:11	8	8	246	2	197	973	70	83.60	40	53.46	CHANGED	KIsl+L+AlGssPlLKpppasVssocohutlIpFL+KhL+l.hs-pLFlYVNsoFAPSPDppltsLYcsFu...oDu+Ll.lpYCto.AaG	...........................Klslhh..+slG.s.sPll..K....p.p..haplsso.pphp..sllcFL.+.KtL.....+.........h...........s.......-........p.............lFlYl...Np.......s.F.A.PuP.Dp.tlusLa.c.s.Ft..........ssscLl.lpYsto.AaG..................	0	65	107	165
+1216	PF04108	APG17		Autophagy protein Apg17 	Wood V, Finn RD	anon	Pfam-B_71163 (release 7.3);	Family	Apg17 is required for activating Apg1 protein kinases [1].	25.00	25.00	25.00	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.35	0.70	-5.67	19	172	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	138	\N	130	174	0	344.20	21	54.31	CHANGED	hpahhtA+poLspspplCp.Apphlsss+ptLppplh.pt+.hpFLhpuLppQhchLhp.....shsphhhtpptspp.hsslhppLpsups+LcpplphLcpThVph.h..............sp-s+sLtDFlspcsl-.Lptslpphlccssth..ptpl-s.htta-s.lpplppth....tpph+phpp....pspht.t.pst......s.hsslsptlpuLE...pEhAslLpSLopHaDhChpuhchh.s.............................................pshstsEhcEhlpVLpsDAtEl.-VltELpsthsphcpthcs....lpsphsphpphastspslhpplpphtp.phstYlthhpshsphhpcppt.........plpptlsplppLspaY-pFlpuYpu.LlhElcRRpts..cp+hccllcpsppcLppl.-pDhcpRppFhhc.GDYLPp-l.WPGhhcpssh	...............................................................h.tah.tuppsLtphp.lhp.Ap..h.thpt.hpp......p.htalhttltpQhthl.t.....hhtth....t.spt.h..thhpphp.h.tplpphht.Lcth.s...h..........................................tpt.ppLhDFlsppslp.l....p..lpph..h..ptth-t....thpp.hptlppth..............h.........................s..t.h.p..tphp...pthsphLpuLspHaD.shhh.c...........................................................t.hs.tpht.p.hpVl.pDstEh.slhhclpphhtphpt.htp....l..p.p....hsthpphhsshpphh.pplsphtp..p....h....spalt....thpshpphh.pptpp..................................plpsthpphp....pLpphYpsFh..p..uYss.Lll..EltRR+ps..ppphcslhcphpcpLsplh-....p-hcpRcpFhtchG-aLPp-l..hssh......s.....................	0	30	65	105
+1217	PF04111	APG6		Autophagy protein Apg6	Wood V, Finn RD	anon	Pfam-B_11747 (release 7.3);	Family	In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in  eukaryotic cells [1]. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the  carboxypeptidase Y sorting pathway [2].	30.00	30.00	30.00	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.09	0.70	-5.38	99	445	2009-09-10 16:48:33	2003-04-07 12:59:11	7	12	305	4	274	429	5	294.70	35	65.03	CHANGED	PlCp-Cs-hLlcpLcpplctspcEpcsYppaL......cplp.........................................tppstpp....h..pcclpp..lctEEpphhpELpclEpccpplsp-lpp.......hcpEtppLc..ppEc.paacchsphphphhchpc-hpSlpsphphspppL-+Lc+oNlaNssFcItH.....-.G.tFGT..INGhRLG+......LssssVsWsEINAAWGQslLLLtslAc+lshp...Fp.p.Y+LhP..hGSpSpIpchs..p.......................................phptLsL......auo.G......sh...phFh.....cp+FDpAMlAFL-slpQh....tppl...p..............ptss......t.....................h.........p....LP.Y..cI..p..cc+Itch.......SI+l..thspc-.pWT+AhKahLTNhKWhLAasSsp...tp	.................................................PlC.-Csc.hLl-thcpplp.sppEppsYtphLcpLp......................................................p.t.p.tpp...pthpp......clpp..lpt-EpplhpcLpplE.ppcttlspp.ltp..........lct.......ctpp.Lc..ppEt.pah+-hsphphp..hhphpc-.......hculpsphchsptpL-+Lc+TNVaNss...F....p..I.H................s.G..tFGT..INshRLGR......Ls.sss..V.-WsEINAAWGQssLLLtslAp.+..hs.hp...Fp.p.Y+LhP.hGs.aShlpphp....................................................ptpplsL..ass.s...sh....phFh.....pp+FD.pAMsuFL-ClpQhtc.l...p.............ptst.......................................thpLP..Y.ch....c..psKItsh...........................SI+h..thspp-..pWT+AhKahLoslKahLsasss....p........................	0	102	152	217
+1218	PF04109	APG9		Autophagy protein Apg9 	Wood V, Finn RD	anon	Pfam-B_12479 (release 7.3);	Family	In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in  eukaryotic cells [2]. Apg9 plays a direct role in the formation of the cytoplasm to  vacuole targeting and autophagic vesicles, possibly serving as a  marker for a specialised compartment essential for these  vesicle-mediated alternative targeting pathways [1].	21.70	21.70	25.70	23.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.15	0.70	-5.55	36	425	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	279	0	277	410	20	322.60	36	42.59	CHANGED	Ds-ltTlsWppVlp+lht.Lcc..tsshosp..............t.ps.....Kp+LsApDIANRIMR+ENYhIALh.NKslLslsl.......................slP.......hlpsp...........hLT+oL-WNlphslh...salFs.ppGpl+ppal+sppRptLupcL++RF.........hhsGllNllLuPFlllYhlLhhFF+Yap-a+psPusl.GsRpaoPhAcW+hREFNELsHhFp+RLshShhhAscYlsQFP..pshhsl.lh+hluFluGulsAlLllholh...Ds-sFhsF-lo.s+olLFYlulhGslhuls+uhlsc.......................-shV.aDPEtsLcpllpaTHYhPscW...cs+hHopcV+pEFspLaph+lhllLcElhSlllTPFlLhFsLspsu.spIlDFFR-aoVcVDGlGaVCpFAhF-hp.cssts	......................................................................t-lpshsWt.cV.p+lht.lpc.pp..thsht.......................................ppcL......sthDIhpRlhRh............cNYh..lAhh..NK........slLshph..........................................lP.............hht.p.h...........................hho+sLcaNlphhlh....t.hFp..pphplp.tpahp.......stp.......c......L.......uptLpp+h.........hhhulhNll.lsPhlll...a.llahFapYhp.h+..p.pPusl.GsRpao.huchhhRcFNE.L.H.hppRLshua...........AscYlspFs..pshhsh.lA+.lsFhuGulhulL..lhh...slh.......Dpclhh......scplLhhlslhGslhsls.Ruhls-....................................................................-phV......asPEth.hptlltahHYhPpcW...puphHs.p.....pl+pEFs.pLaph.....+hl...hlLcElhS.llTPhlLhF.l....pu..cIlDFFRpFTVcVsGlG.lCSFA.hDh.cpts...p......................................	0	94	148	221
+1219	PF04655	APH_6_hur		Aminoglycoside/hydroxyurea antibiotic resistance kinase	Waterfield DI, Finn RD	anon	Pfam-B_4369 (release 7.5)	Family	The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation utilising ATP. Likewise hydroxyurea is inactivated by phosphorylation of the hydroxy group in the hydroxylamine moiety [1,2,3].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.58	0.70	-5.23	9	681	2012-10-02 22:05:25	2003-04-07 12:59:11	9	5	456	0	126	779	46	215.90	33	83.38	CHANGED	RWcLptcGtshsscoShllPVh...psDGssAhLKlth..tc..pEptGthl.LsaWsGcGAVRlLsp-..sushLLERhsGsRsLspls.cttDcpAstllAthhsRLauspstPhP..LpPLp-hhsuLhpts.spt.st......cttL.tssAusstpLlusPp-.RsLHGDLHasNVLsusc.....csWLAIDPcsLhG-sGFDhAshhsss.tc......shcstclc+ph-llstslslD.tRlhsWslAhss.SusWthEDG	............................................................................................................................Wtl.........s.........s.suhlh.V.....h..s..G.t...............A.hlKh..........pE.h.....h..Lh.....h..h.s...G.p...G..A.s.c.lls.........tc.....................p.......s..hhLLEhh..utR....L.u......p.....l.....s..................s...D...p.....A...s...pl..h....A........p...l..hu...+........La....u..s..s..............s.h.....P..s........s...L....h...s.......lp...-...h.....h...s.s......hh..pps.....tp.s.st...................sppphh..hpsAt.h..s..c...p...l...h.u......s...s..u......-.........p......h...L.....HGDLHa-N..ll...t.......us........................cs.W.....L....s....ID....P.p.s.L.s.G-.sGF-h....ssh..hh.s....h-c......shs.s..p...p..l.tph.h-.hhs.c.slsl..D.cR.hhsashuhss.sAhW.ht..................................................................................	0	40	79	103
+1220	PF00807	Apidaecin		Apidaecin	Bateman A	anon	Pfam-B_1489 (release 2.1)	Family	These antibacterial peptides are found in bees. These heat-stable, non-helical peptides are active against a wide range of plant-associated bacteria and some human pathogens [1]. The Pfam alignment includes the propeptide and apidaecin sequence.	25.00	25.00	31.70	30.20	23.50	17.60	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.47	0.72	-4.26	2	104	2009-09-10 22:49:59	2003-04-07 12:59:11	12	9	4	1	40	92	0	27.70	92	82.49	CHANGED	hctcPEAEPGNNRPlYIPQPRPPHPRl.	.REAEPEAEPGNNRPVYIPQPRPPHPRLR.	0	40	40	40
+1221	PF04711	ApoA-II		Apolipoprotein A-II (ApoA-II)	Kerrison ND	anon	DOMO:DM04862;	Family	Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma.\	 Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge [1]. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear [1]. In bovine serum, the ApoA-II homologue is present in almost free form.\	       Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS) [2].	24.30	24.30	24.70	24.70	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.41	0.72	-4.09	5	38	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	26	44	15	41	0	73.20	61	73.18	CHANGED	QAEEoslQSLsSQYFQTVTDYGKDLMEKAKuSELQuQAKAYFEKTQEQLTPLVKKAGTDLlNFLSpFl-L+cQPAT	.............QA-EsslpSLhSQYFQTlTDYGKDLhE...KVKoPELQAQAKAYFEKo+EQLTPLVKKAGT-LlNFLS.Fh-Lc.p.pPA........	0	1	1	1
+1222	PF04691	ApoC-I		Apolipoprotein C-I (ApoC-1)	Kerrison ND	anon	DOMO:DM04729;	Family	Apolipoprotein C-I (ApoC-1) is a water-soluble protein component of plasma lipoprotein.  It solubalises lipids and regulates lipid metabolism.  ApoC-1 transfers among HDL (high density lipoprotein), VLDL (very low-density lipoprotein) and chylomicrons.  ApoC-1 activates lecithin:choline acetyltransferase (LCAT), inhibits cholesteryl ester transfer protein, can inhibit hepatic lipase and phospholipase 2 and can stimulate cell growth. ApoC-1 delays the clearance of beta-VLDL by inhibiting its uptake via the LDL receptor-related pathway [1]. ApoC-1 has been implicated in hypertriglyceridemia [2], and Alzheimer's disease [3].	27.60	27.60	28.40	30.60	26.80	27.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.86	0.72	-4.28	6	41	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	29	5	13	45	0	55.00	47	71.03	CHANGED	ss-hSSshpplsDKLKEFGNTLEDKA+sAI-cIKpS-lssKTRsWFoEsFpKlK-KlKss.	......tP-lussh....D+LKEFGsTLEDKA+psIp+I+QSEhssKTRsWFoEsapKVK-Klp.s.....	0	2	3	4
+1223	PF01333	Apocytochr_F_C	Apocytochrome_F; 	Apocytochrome F, C-terminal	Finn RD, Bateman A	anon	Pfam-B_1294 (release 3.0)	Domain	This is a sub-family of cytochrome C.  See Pfam:PF00034.	28.50	28.50	28.50	28.70	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.48	0.71	-4.26	49	697	2012-10-02 20:27:15	2003-04-07 12:59:11	14	5	642	30	66	553	134	114.80	74	37.15	CHANGED	NNslasAsssGpIopIpt..p-..............c....GGaploI.possGppls-plPsGP-Ll..VscGpsVpADQsLTsNPNVGGFGQs-sEIVLQsPsRlpGLlsFhhsVhLAQlhLVLKKKQFEKVQhA.EMNF	................NNTVYNAousGhVoKIlR..KE....................K....GGYEITI..scs.SD.GcQVVDIIPPGPELL..VSEGEsIKlDQPLTs...NPNVGGFGQGD.AEIVLQDP.LRVQGLLhFhASVILAQIFLV...LKKKQFEKVQLuEMNF......	0	16	40	56
+1224	PF01442	Apolipoprotein		Apolipoprotein A1/A4/E domain	Bateman A	anon	Prodom_1521 (release 99.1)	Domain	These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Swiss:P02647 Apolipoprotein A-I. Swiss:P06727 Apolipoprotein A-IV. Swiss:P02649 Apolipoprotein E.	90.00	5.00	90.00	5.90	89.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.09	0.71	-11.79	0.71	-4.81	46	1816	2009-01-15 18:05:59	2003-04-07 12:59:11	13	29	249	39	715	1765	2	196.40	12	86.35	CHANGED	thlp-shcplssYtpcLpppLsPhs...p-htspLsc-sptl+pcl......ppDlE-l+s+lpPahsElpphlppph-chRp+lsPhspcL+c......phppchccLpppLsshsp-..................h+sph......cpsl-sl+spLtPhs-ph+p+ls..................p+Lcpl+ppssspsp-hpsplpppl...ppl+c+lpstsc-l+ppL...............................................................................pPhsEshcpplhphhE	...................................................................................................................................................................................................................................................................................................................t.......................................................h.......ttl....................ttt...h.tt.htt.......t.......l...t....thh....p....p...h...p...p......t.l....t.p...p.......h.cp....l..pp....p....l...............s...s.......hhpphp.p......................pl....s........pp...s......ppl.....pp.p....ls.......sh...s...pp........................................................................................hpppl..................pp...ps....p...ph...p...splssh.......s....cpl...p......pphs............................................................................................pplpphp...p...p.l...s..p...ts.....p....p....ht...s.p...l..p...p...ph...........pphp...ppl....st.t....hp.......slpppl....................................................................................................................................................................................................................................................................t..t.th...........................tt......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	146	285	400
+1225	PF01583	APS_kinase		Adenylylsulphate kinase	Bateman A	anon	Pfam-B_578 (release 4.1)	Domain	Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate.  This domain contains an ATP binding P-loop motif.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.78	0.71	-4.57	20	3100	2012-10-05 12:31:08	2003-04-07 12:59:11	15	31	2402	54	1024	3172	2394	154.70	50	43.89	CHANGED	+GsslWhTGLSGuGKSTIAtALEcpLhppG.hpsYhLDGDNlR+GLN+-LGFSccDRpENIRRluEVAKLhu-uGllslsuFISPacp-RctARplhpp.........cFlEVFVDsPL-VCEpRDPKGLYKKARsGcIKsFTGIDuPYEsPpsPElhlcssppsl	.......................usllW.h.TGLSGSG..K..S..TlAsALEc.......tL....h....p................p.G.....hp.....s....Yl....L.D....G....D......N..l....R.....+.....G.....L....s........p.................D..........L.......G.....F.......S..c.....t..D.R........p..EN........I....R..R.....l..u....E..V....A.....+.....L.h.....s....-.u....G.l..l.s.l..su...F..IS.P.a...+.t..-R..ph..sRchlsps.............pF..l.E.......V.a..Vcs.P.Lp..lC..E....p..R..D........P........K.................G.....LY.+KA.....R.....u....G...E........I+.............s........FT......GI....D....u..s............YEs..P..p..sP..-..lplcsp...ph........................................................................................................	0	317	597	837
+1227	PF03440	APT		Aerolysin/Pertussis toxin (APT) domain	Griffiths-Jones SR	anon	SCOP	Domain	This family represents the N-terminal domain of aerolysin and pertussis toxin and has a type-C lectin like fold.	25.00	25.00	36.70	41.30	24.80	24.80	hmmbuild  --amino -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.83	0.72	-4.28	5	77	2012-10-02 16:37:33	2003-04-07 12:59:11	9	3	33	26	10	90	2	81.00	49	19.25	CHANGED	sEPVYPDQl+lsuLG..pGVCuscYRPLTR-EApS...l+sNLVuhMGQWQIoGLADtWVILGPGYNGEIKsGoAGuTWCYPToPsou	..................lYPDQlhhhsLG..ptlCsstYRPlTRpEApu...lKusllshMGp..WQIoGLAssWVIMGPGYNGEIK...G.o.A.u.sTWCYPssPs..s....	0	3	5	5
+1228	PF02610	Arabinose_Isome		L-arabinose isomerase	Bashton M, Bateman A	anon	COG2160	Family	This is a family of L-arabinose isomerases, AraA, EC:5.3.1.4.  These enzymes catalyse the reaction: L-arabinose <=> L-ribulose.  This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into  L-ribulose by the L-arabinose isomerases enzyme [1].	27.00	27.00	27.00	27.50	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.15	0.70	-5.49	38	1076	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	1019	9	200	697	49	349.80	58	71.66	CHANGED	M.hph.cphEhWFlTGSQHLYGpEsLcpVupcoppIssuLNsoupLP.hclVaKslsoTs-pIpplhp-ANss-sCsGlIsWMHTFSPAKMWIpGLptLp..KPLLHLHTQaNp-IPWsoIDMDFMNLNQSAHGDREFGFIsuRhphpRKVVsGHWpDtcVpccIusWhRsAsuas-upplKVARFGD.NMRpVAVTEGDKVEAQIpFGaoVssaGlGDLVphlssVo-p-lcsLlpEYpspYslssshpp.ssppcpulpptA+lELGl+pFLc-GGasAFTTsFEDLtGh+QLPGLAsQRLMA-.GYGFGuEGDWKTAALlRhhKlMupGh...sGTSFMEDYTYchssGschlLGuHMLEVCPSIA	..............................................................................................................................MhhhcsYEVWFVlGSQHLYGsEs..L+QVs.pHAcclVsu.L.NspucL..P.sKlVhKPlsTosDEIosls+-ANYD-cCAGllsWhHTFSPAKMWIsGLshLp..KPLLphHTQFNsslPWDoI....D.......M...D......FMN....L.NQoAHG....s....R....EFGFIsARMRpp..+.tVVsG.H.W.p..D.cp.s.pc+IusWMRtA...luhp-o+pLK...VsRFGD...NMR.cVAVT-GDKVuAQI+FGaSVNsauVGDLV.p.lVsu..lSDuD.l.sALl-E.Ycs.pYshssusp.....p.G.-.++psVh-AARIELGh+RFLEpGGa.cAFT.TsF......E.....D....L.........a..........G.....L.....K..Q...L..P.G.....L..A...VQ.R.LMpp.GYGF..uGEGDWKTAALlRlMKVMusGL....p....GGTSFMEDYTYcFc.pG..N-hlLGSHMLEVCPSIA.................................................................	0	70	136	171
+1229	PF02311	AraC_binding		AraC-like ligand binding domain	Mian N, Bateman A	anon	Pfam-B_12588 (release 5.2)	Domain	This family represents the arabinose-binding and dimerisation  domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH)  DNA-binding motif Pfam:PF00165. This domain is distantly related to the Cupin domain Pfam:PF00190.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.58	0.71	-4.48	58	10833	2012-10-10 13:59:34	2003-04-07 12:59:11	14	20	2515	10	2189	13862	1372	132.60	12	46.69	CHANGED	hsshtthpsph.tpta.s..HhHs..tatlthltpGssph.phsspp.....aplssGclhllsPsp.Hphtsss.........pt..saphphlhhpsshltphhtphthht...................hhpsspltphlpplhptl............ppttsshhtpshlhpll	.....................................................ht..................h........HhH.s....th.p..l.h.h..s..h....pGs.s...p..h..t.h...s...s..pt......................ah..l.psGslh.h..l...s..s..s..p..h...H...p....h.t..sss............................................sh.p..h...h..h..l....h.h......p.......s...t..h.......h..............t...h...h...t...t...................................................................h.............h....hh...........................................................................................................................................................................................	0	712	1314	1755
+1230	PF03869	Arc		Arc-like DNA binding domain	Finn RD	anon	DOMO:DM07094;	Family	Arc repressor act by he cooperative binding of two Arc repressor dimers to a 21-base-pair operator site.  Each Arc dimer uses an antiparallel beta-sheet to recognise bases in the major groove [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.28	0.72	-4.34	3	753	2012-10-02 18:44:02	2003-04-07 12:59:11	9	3	491	41	123	550	31	46.50	30	53.16	CHANGED	uRcsP+FNlRhPcEVREpl+cVAEuNGRSMNSEIlQRVp-SLpKEGslsu	..............ph....lR.lPp..pl+-plcphAcpssRShNuE...l....lthLcpult.p......t...................	0	21	58	85
+1231	PF04659	Arch_fla_DE		Archaeal flagella protein 	Waterfield DI, Finn RD	anon	Pfam-B_4437 (release 7.5)	Family	Family of archaeal flaD and flaE proteins.  Conserved region found at N-terminus of flaE but towards the C-terminus of flaD [1]. 	20.80	20.80	20.80	21.50	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.47	0.72	-4.20	22	97	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	55	0	68	99	1	97.30	34	28.55	CHANGED	.cspcps+LcslP.--shu.hlshcWLEFLhp+sGhsshs-sL-YYhslGWlS-cshscLhcas+Ghph.p-p.....pssscLohsDHllSLLaIE+LsGcp	.........tppshLpplP.c-shuphlshcWLEFLlc+sGhpsh.csL-YYhslGWIS-cVhspLhcas+Ghch.t.c...............psstcLs....hpDHlhSLlaIp+LsG....................	0	8	36	56
+1232	PF01917	Arch_flagellin		Archaebacterial flagellin	Enright A, Ouzounis C, Bateman A	anon	Enright A & COG3354 & COG3353	Family	Members of this family are the proteins that form the flagella in archaebacteria.	29.30	29.30	29.40	29.40	29.10	29.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.30	0.71	-4.68	114	362	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	94	0	241	376	91	185.90	22	88.87	CHANGED	GtsG.luslIlFIAhVlVAAlsuuVllsoushlpppupssucpsspplsoslplhssss...........ssssssshs...........lslhlp.NsGus.slclspspls..lh.ss............................................................................................................................................................................................................................................................tlhshpssstshsss....................pssls.G-hstls..ls...............................................hssssphph.plhschGu.ssslph	............................u.sG.luolIlFIAhVlVAAlsA.uVllsoushlpppupssGcpusppluoslplhsssu...............................ssssss..s..lsp......................lslhl..p..ssG..us..sl...-lsps.plt....lssss..t.....ht.h..st..............................................................................................................................................................................................................................................................................................................t..thshhsl.pstssshtss.................shlp...u-...hhtlh.lsht....................................................................................................h.s.tp..thph.plhsp.Gssh.h....................................................................................................................	0	43	130	195
+1233	PF01637	Arch_ATPase	Archaeal_ATPase; 	Archaeal ATPase	Bateman A	anon	Pfam-B_1507 (release 4.1)	Family	This family contain a conserved P-loop motif that is involved in binding ATP. This family is almost exclusively found in archaebacteria and particularly in Methanococcus jannaschii that encodes sixteen members of this family.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.46	0.70	-4.66	56	1765	2012-10-05 12:31:08	2003-04-07 12:59:11	13	92	762	3	830	5495	1741	203.60	17	44.02	CHANGED	FhDREcELcclcchhccs.t.lhllYGPcssGKTuLL+phlpph..thsh....tslYhpshcphhttthcth........................tcpltcth...........................tpsl.psth...........phs.hsls.hhchlpccscc....lsllhDEl.phh..t.p................tstthlptLhphh-h..stphchhhl..lsuSS....-Glhhc..........lhGRppa.hplcsh.....hphhccsFcpl.....t....sc.ch.-clachsGGpPthLtpl	.......................................................................................................hhsRppE...l....p.........l.........p....h.....h.......p........p........t.........................p....h.....h...l...l...h.G..RchGKTs....L.l.....p..p..h...h....p...ph....................................hsla....h.........s...h......p....p....t..t....t....p.....p.....h.p..p..h............................................tp..h....p..hh...............................................................................................................t......h....t.........h..........................t.......h...t.s..h..p..p...h.h...p..h...l....t.p....p..tpt................hll....h...l.....D.Eh...p.lh........p.......................................................................t..h.......p...h.ltp....hh....pp.................p......p.....p......h...h...hl........h...s..G...S..t.........s..hh.p............h.t.....p.t....s......h.h...s......p..h....p....h...h.l.p...h....................h.phh.........t...................................t....h...........hht...hhsGhs......h...............................................................................................................................................................................................................................................	0	292	489	679
+1234	PF00798	Arena_glycoprot		Arenavirus glycoprotein	Bateman A	anon	Pfam-B_1047 (release 2.1)	Family	\N	25.00	25.00	28.70	28.60	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.84	0.70	-6.09	20	431	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	50	30	0	349	0	309.30	46	98.66	CHANGED	MGQlloFFQEIPpllpEAlNIALIsVSLlAIlKGllNlaKsGLhQLlhFLlLAGRSCS...h.......pIGc+pphpolplshoplh....tphPtsCplNNoHaYl+sspsop.Gl-lolTssolls.......ph..tthsNlosChcssptt.....asLpWllsslHash.pssphl.stspspssuthpIQhNLoc....tpcstpaspplhsultclFGshpts.........................C......stsshpaLI.IQNoTWp...........scCphs...Hhsol+lLhpsstpphl.oR+LhuFFoWoLSDSsGNDhPGGYCLE+WMLluucLKCFGNTAlAKCNhsHDSEFCDMLRLFDFNKNAIcoLpspocpplNLls+oINuLISDsLLMKN+L+ELMsIPYCNYTKFWYlNHTtoGcHSLP+CWLVpNGSYLNEocFRN-WlhESDpLIoEMLsKEYp-RQG+TPLuLVDlCFWSTlFYosolFLHLlGIPTHRHIlG-uCPKPHRLsppGlCuCGhYpp.sK	..MGQlloFFQElPphlpEshNIsLlAlSllAllKGlhNlhpsGlhtLlsFLhLsGRSCo.......h.......hhtthhEhQolphsMspL......shP..CphNsSHhYlphGpp....hplohos.oll......................pp.sslosshppp........aslh.hhsshthsh...s.h..shspshstG.h.lQhNloh....s..shp.stphtsthhphahthh.s...........................C.........s.sh.hlh.hpspsW.spC.hs....hsh.thl.tptt.....tRplhuhFoWsLoDstG.p.................................................................................................................................................................................................................................	0	0	0	0
+1235	PF00843	Arena_nucleocap		Arenavirus nucleocapsid protein	Bateman A	anon	Pfam-B_1333 (release 2.1)	Family	\N	22.70	22.70	22.80	33.30	21.70	22.60	hmmbuild  -o /dev/null HMM SEED	534	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.76	0.70	-6.62	17	468	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	52	24	0	392	0	313.20	54	96.85	CHANGED	ScpVPSFRWTQSLRRGLSsaTpsVKuDVl+DA+ullsuLDFspVupVQRlMRK-KRsDsDLs+LRDLNKEVDsLMpM+SsQ+sslLKVGsLo+DELM-LAoDL-KLKpKVhRsEt.ssssGVYhGNLTsoQLspRuclLchlGh....pt.pssssGVVRlWDVK.....Dso.lLsNQFGSMPALTIACMoc..QGuEshNDVVQuLT.sLGLlYTVKYPNLsDL-KLoppHssLplITp-cSuINISGYNhSLSAAVKAGAChlDGGNM.LETI+VpPssFoolIKslLpVKp+EuMFVu-sPGpRNPYENLLYKlCLSG-GWPYIuSRSQIpGRAWDNToVDLsscs.......ssspsPh+sGus.pLssLo.sQEt.l+cuhtpLDPssTTWlDIEGsssDPVElAlYQPsoGpYIHCYRcPpDtKuFKspSKaSHGlLlKDLtsAQP.GLlSslIctLPpsMVlTsQGSDDI+KLh-hHGR+DlKllDVchou-pARhFE-tVW-+FshLCcpHsGlVlpKKKKGss.s.o....pPHCALLDCIMFpuslsGt	......................................................................................................................................................................................................................................................................................................................................YIuSRopIhGRuW-NTsVDLss.c.s.......sssptP......pt.su.tshp........usLo.tQphhlK-.uhtpLDPssshWlDIEG.PsDPVElAlaQPsuupYIHhaRcPpD.KtFKpsS+aSHGI.lpDl.sApP.GLhShVIthLPpsMVlTsQGSDDIRKLhD.pGR+DlKLlDVcLop-puRpaEptVW-+atcLC+hHsGlVlpKKK+ttt....hp...................................	0	0	0	0
+1236	PF00025	Arf	arf; 	ADP-ribosylation factor family	Sonnhammer ELL	anon	Swissprot	Domain	Pfam combines a number of different Prosite families together	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.12	0.71	-5.03	20	5460	2012-10-05 12:31:08	2003-04-07 12:59:11	16	68	556	115	3415	26010	2506	161.80	36	79.30	CHANGED	hsslhupLhu....sKEhRILhLGLDsAGKTTILa+Lphs-lso...shPTlGFNlEolpa.....+Nl+FslWDlGGQcplRPhWRsYassTsulIaVVDSuD+-..RlsEu+pELpslLsE-ELp...sAslLlhANKQDLPsAhSssElpctLuLpp.......l+.....sRsWpl.sssAlpG-GLhEGh-WLussl	...........................................................................................h.......h.h......pc.c..h..+....l..l.h......l............G.LD..s.......A....G...K.......T.........T.....l.....L.......h.......p........L.....p.......h..........s........c.......h....s..p...................h.h....P.............T........l................G..........F.....N.....l......c......p.....l....p..h............................p...s......l........p.........h.......p...l..........W..............D....l.......G............G...........Q.........p.........p..........l............R.............s.........h..........W.............+...........p........Y........a.........p..........s.........s............p...........u...........l....l..........a..........V..........V................D..............S..........s..........D..........c.......c...................R......l............t........-............u.......+.......p........E.....L.....p.........p.......h.........L.............p...........c........c.........c.....L...p............................s..s.....s...l....L.....l....h..A..N.....K............Q.............D..l....s.....s.........A.............h.....s.....s......s......E........l.....p....c....t......L..s..L..p..p.................................lp...............p.R...t...h....h...l............s..s...s..A........h........p......G......p........G......l..........-.uh.cWL.p..h.............................................................................................................	0	1187	1801	2657
+1237	PF01316	Arg_repressor		Arginine repressor, DNA binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.06	0.72	-4.42	10	4229	2012-10-04 14:01:11	2003-04-07 12:59:11	16	5	2719	38	530	1777	256	69.40	34	44.70	CHANGED	hsKspRpptI+cIIppcclsoQsELlctLpcpGls.VTQATVSRDL+ElshVKVt..ssGphhYsLss-sph	..........................p+ppRh.p....hI+.pl.lpccc..lp...oQpEllptLpc.p.Ghp.lTQuTlS...R...D...l...+-.....l....s...llK.lt.stps.p.....hhY.sLssp...h...................	0	156	308	440
+1238	PF02863	Arg_repressor_C		Arginine repressor, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	25.00	25.00	30.40	29.50	21.60	18.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.18	0.72	-4.51	146	4296	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	2715	74	531	1750	261	69.90	29	45.54	CHANGED	hlpphllslctspshlVl+Th..PGsAphlAshlDph.phsc..IlGTlAGDDTlhlls+stpssppltpplpph	.................h.lpchllsl-hsst.hlVl+Th..PGs..Aphl.usllDp.........h..phcp.........IlGTlAG.D.DTlhlls.csspsupplhcplhp................	0	156	310	442
+1239	PF00491	Arginase	arginase; 	Arginase family	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.00	22.00	22.20	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-12.03	0.70	-5.11	347	5883	2012-10-01 22:40:15	2003-04-07 12:59:11	16	18	2993	272	1841	4658	4174	269.20	24	85.75	CHANGED	tclsll.GlPhDt...s.ssh.RsGs.chGPp......ulRpu.h.ht............hs...s................hplh....................................D......hGD.l........shs.............................p.tp.s...hcplpptspp.l.....lp..p.................uths......................lsLGGDHolohshlpuh...scth...................st..lullahDAHsDh.ps...............tsst..........hs.HGsshp...p..................................shp..hhlp.....tphhplGlRshsps....-...h.........t.h...cthGhp..hhshcclpphuh.t..th...hcphhptl.....t....t....slYlShDlDslD.PuhAPGoGTPts.G.Glohc-shtl.lct.l...ts.....hpl..lGhDlVEls.P....shD..s..................thTuhhAupllh..p.hhs	.....................................................................................................................................................................phsllGhPhDh.....h..sph..Rs.Gs.....c......h.GPp........ulRps.h.ht.................p...s....................................hplh..........................................D.......hGD.l..........shs....................................................h...s.t.p..h.........hpplpptspp.l..lp..p.....................sths.......................................lslG.GD..H.plshshlpuh....scph.....................................s..lullahD.AHs..Dhps...................................ss.t...........hs..HGoshtp................................shpp...shlps........pphlpl.GlRshsss.........ph.................................phh.....cctG..hp.......h.hs..h..p.c...l...p...c.h.......uh.....t...........tl...........hpplh.phl.....t.........sp.....slYlohDlDsLD.P.u.hA........P.G..s...........G.....T...P....s.......s........G...G.......l.o...c.c.s.h.pl.lct.l.....tp............hpl.....suhDlV.E....ls..P....shDt.s...................hTuhhuuplhhp...h...............................................................	0	557	1073	1504
+1240	PF00764	Arginosuc_synth		Arginosuccinate synthase	Bateman A	anon	Pfam-B_888 (release 2.1)	Family	This family contains a PP-loop motif [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.30	0.70	-5.42	12	4339	2012-10-02 18:00:56	2003-04-07 12:59:11	14	19	4054	37	1169	3498	3319	374.20	40	92.38	CHANGED	VLAYSGGLDTSVsIshLp-chs..EVlulslDlGQst--lctscp+AhchGshcphslDAK-EFsc-Yha.uIpANAhYEs.YPLuTALARPLIAK+lVEsAcccGApAVAHGCTGKGNDQlRFEsshtshsPplclIAPhR-hshT.....RcctIpYAcp+GIPlssshcpPaSIDcNlWGRulEuGhLEDPhstPPc-lataTpsPtcssppP-hVcIsFcpGVPVuls......Gcphss...lplIpphNElAGtpGVGRlDhlEDRllGlKSREhYEsPuAhlLlpAH.csLEslTLsR-.h+FKchl-pp.auELlYpGLWasPL+csLcAFIs+oQE+VTGhVRV+La+GshhlhGRcSshu.LYstcLsoa-.scshDQptupGFlphaGLpu+lap	...........................................lLAYSGGLDTSlhlhWLpcch....t-VlAh.su.........D..l....G..Q..s............-....-..h...-.s..l.c.c....KA.hphG...A...p..c....s..hl...lDs+cEF...sc.-a.lhssl.pus.A........h...Y....E....s....p....YhL.sTul.u....R.P...l...I...u......+tLVc.....hA+..cpGussluHGsTGKGN.D....................Q..................VRFEhshh.u.ls.PpLcllAPWR-hs.h.h.....uRc-hlp....aspppslsl.t...h...........s........h...c........p....sYShDpNlht.t..ohE.......u.t.LE..ss..h.....s.....p.....s....s....c.s....h.a......th.o.h.ss.-.p.s.ss...........p.s-.lplpF-p..GhPVul..N......................Gcp.h.ss......spllhcLNclu..G+HGlG.R.lDhlENRl..lGhKSRGl.......YEs..................PGuslLhtAH.ctLEs.lsls+-.shc.h+.c.t.l.tt.c.hucLl.Yp.........GhWFsP..p...p.hLp.s.hl.pc.....s.ppt.V.oGpVplc.......La+G.s.hh.lh.u.pcS.s...p.s...L.Y...stc..hsTa.p..c..s...c.....s..a.stpcAhGFIplhuL..p...t..........................................................................................	0	359	740	981
+1241	PF01960	ArgJ		ArgJ family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of the ArgJ family catalyse the first EC:2.3.1.1 and fifth steps EC:2.3.1.35 in arginine biosynthesis. 	25.00	25.00	34.00	28.60	21.50	16.80	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.42	0.70	-6.06	139	2527	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	2367	44	817	2155	2927	371.30	40	94.80	CHANGED	FpsuuspuGlK..................ps.+hDLullh..sp...tsussAGVFTpNphpAAPVhlsccpl.......pss.p....h+AlllNSGNANAsTGppGhpsAtphsphsAptLslss............p..........pVlluSTGVIGp.L.Ph-pltsulsp..hst.tL.........s........ts..shpsA...AcAIM.TTDThsKtsuh....phpls.Gp...plpluGlAK..GuGMIcPNM.......ATMLuFlsTDAslsssh.LpphLcpulcpSFNpIoVDGDTSTNDolllhAsG..tu.ss............s.lsp...ts.t...hptFppuLptVstcLActIs+DGEGATKhlplpVpGAtscp-AcplA+ulusSsLVKTAlaGpDsNWGRIlsAlG.hu.....Gs...sh-ssclslhl.........s....s.............lhlhpsGthss.as.E..ppupphhpp.........p.-lpIpl-L.....st.Gs..upussWsCDLoa-YV+INA-Y..RT	...................................apsuuhpAGlK..................ss...+tDlullhss....ss..u.s.s.A.uVFT.pNphpAAPVhhs+ppl.......ssu..p.........hp...AlllNSGsANAs.T.........G........tp..Ghpcupphspts...Aptl...s..ht..s.............p...............pVhlsST....GVIG..p...LPh..-.+lhs.ul.sp..hh.s.sh...............tts........shtsAAcAIh...TTDThsKtssh.....p.h.p.....l.....s.....Gp.................slsluGhAK..GuGMIpPNM...................ATMLuF............lsTDAsls.....s.sh.LpphLppsscpoFNpIoVD...GDTSTNDslllhAs.Gtu...st............................................lpt.......tp.p......httFppALptVspp.....LAptls+DGEGATKhlpVpVpGAt.opp-AcplA+slspSsLVKTAla.GpDsN.W..GR.IlsAlGhu................us...........shD.s.splslhl......................ss......l.lscpGt.ss.....as...E....ptspthhpp...........................................c.-lpIplcL..........sh...G...s........u.p.ussWsCDLoa-YVcINusYRo...............................	0	273	556	708
+1242	PF03308	ArgK		ArgK protein	Mifsud W	anon	Pfam-B_3540 (release 6.5)	Family	The ArgK protein acts as an ATPase enzyme and as a kinase, and phosphorylates periplasmic binding proteins involved in the LAO (lysine, arginine, ornithine)/AO transport systems.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.69	0.70	-5.62	9	1738	2012-10-05 12:31:08	2003-04-07 12:59:11	11	13	1333	12	625	2137	1076	266.50	40	60.95	CHANGED	LARAITLVEsccs....pAppLLcclhPhsGpAphlGlTGsPGuGKSTLl-tLhtpLtccGh+VAVlAVDPoSPhTGGuILGD+hRMpchu......scsGsFIRshsopGsLGGluptTp-sltLh-AhGaDVlllETVGVGQSEV-lsphsDshlllplPGsGD-lQuIKtGlMElADlhVVNKAD...htsActstp-LphALcL.p......................c..ctsWpPPllcssAspGcGlcELW-tIc-H+chlptoGhhtp+RRppttc.hhpllpstlhs+lpuu.s	........................................................................................LA+AITLlES..pp.stc....................hu.p..pl..L...p...t.....l.......h........P...........t..........s..........G....p.........u......h.........R..l...G.I.T.Gs.PGAGKSThl-ulGh.t..L..........h...c..c...G...t...+..VAVLA.....VD......P..S......S...s......hoG.....G......SI...L......G....D.+T...R...Ms.cLu...................................p.c......s..uF.....IR..P...s.s...o...pG.....p.....L....G.....G...l.up.....t....s.....+E.....shh.lh.E.A.A.......G.....aDll....lVET.VG...VG.Q...SEs...s.V.sphsD...shl.hl......h......lsusG......DpL.Q................u...I.K....+....G.l..h....El...AD......l...ll.lNKuDh.....pps.Apt.u..t..p.-....h.p.s.u.L...+...lhpt..................................................................................p....tstWp.P...VlssS..A..h....p.....t........c..Gls-lW...pt.l..c..apph.h..pt....s...G...thp..t..pR....p..pQ.t.htahhp.hpptlhpph....s...................................................................................................................	0	245	446	556
+1244	PF02374	ArsA_ATPase		Anion-transporting ATPase	Mian N, Bateman A	anon	Pfam-B_1201 (release 5.2)	Family	This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell. 	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.70	0.70	-5.38	11	2686	2012-10-05 12:31:08	2003-04-07 12:59:11	10	13	1221	72	1090	14632	4072	239.70	25	76.97	CHANGED	h+alFhuGKGGVGKTTsSsATAlp..Luc.G++sLllSTDPAHsLSDuFsp......chG+pPTKlp..-NLhuhEIDPp........hplpchhtpshc.hsssh...thphlpshlp-thsu.PGh-EhhuFsphh+ahc......sscaDlllFDTAPTGHTLRLLphPsshsphhc+hhchpp.....ltshhp.h.t...hGusshs....chhppl-pphEplcthp-hloDPspToFhhVshsEchSlhEocRshptLtpaGlcscslIVNp.llPEsspp....spahpu++plQpKaLcpI--hFpshslsclPLhppEltGlcsLpchuphLhs	...........................................................hl.hh.s.G..KGGVGKT..Th............us..u.h.Alt...........h...A...p...........t...G.......c.......c..ll.l..l.............o.o..D.............P.....A....p..s.......L..........u.........p...s..h...s......................................p..h..s..t..p...........h.........l..........t....................................s...........s........L..........s...........h....p...l..D.sp......................tt.h..p.c...h..h....t...p...h.....h.....t............h.....t...t.....h.........................t.....h........s....h.....h.....p....c.......t..h.....s.....u...............P...s.........h....p........E.....h....h.....s....h..t.........p....h..t..c.hhp.........................ptpa...-...h...llhDoAP...T.G..........c..TLc...h..Ls......h..P...p.th.........p...t..h..l.......t.........t...............t...............................................................................................................h..t.t..h.t.t.....................t....h..........t........t...........h............t..........hts...........t...........othhh.V..h.sp..s..l.Es.ph.t..Lt........t..h..t.ll..lNt...h..h............................................................................................................................t.....................................................................................................................................................................................................................................	0	393	721	952
+1245	PF02040	ArsB		Arsenical pump membrane protein	Mian N, Bateman A	anon	IPR000802	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.53	0.70	-5.52	4	1841	2012-10-02 15:12:49	2003-04-07 12:59:11	10	4	1464	0	343	2231	187	367.80	44	95.11	CHANGED	LAhsIFLLTLVLVIWQPKGLuIGWSAslGAVLALIsGVVshuDl.sVhsIVWNAThTFlAVIlISLlLDEhGFFEWAALHhu+.hupGpGh+hFsalsLLGAhVAALFANDGAALILTPIVlAMlhALtFsctsshsFlhAuGFIADTsSLPLlVSNLVNIVSADYFslGFhEYAShMlssslhSllASllVLaLaFRKsIP.sYsLppLKsPtpAIKD.shF+luWhlLhlLLlGaFs.E.luIPVSslAushAlIhlhlAp+u+AlpTt+Vl+tAPWpIVlFSlGMYLVVYGL+NAGLT-lLuslLsshu-pGLaAushGhGFluAhLSSIMNNMPTVLlsALuIsuSsssGhl+EAMIYANVIGsDLGPKITPIGSLATLLWLHVLopKGM+IoWGhYF+TGIllTlPVLhlTLsuLhLpL	...........................................................................................hAhhlFlhT.l.l....h..l....l...W..p....P......+......G.....L.s...l.........u...h..s..A..h..h.G...A....h...l......s.l....l....h...G.l....V...p..h..s...D...l................V......h....s..........l........V.......W...s.A....o.h..s...F...l.u.l.I.lI.Sl.lLD...c....G.F.F.-....W..u..A...l+.h.s.+.......h...up.....G...p.....G..h.tLF.sal.h...LLG.AhVuAhFANDGAAL.ILTPIVlAhl...h..sLs.a..........s.p......t.s.h.......h...s.......Flh.A.u...GF..I..A.D.......o....u....S....L....P...Ll..V.S..N..L.V...N.I..l..o....A.....c....a.....F....s....l..u.F..h..c.Ys......u.....h......M.h........s..s.l.h.....u...l....l...A..o...l..l.....h...L...a...l.....a......F.........R....+.......s.....l....P....p...p...........a.....-.....h......t...............l..........p.........p.....P..t........p.........A......l...p.............D...................t.......h.....F......+.....h..u.....h.h.l..L...h......l.L.......L......h....G......a......h............l...h....E.......l........s........l...........P................l.........S..h......l....A...s..l....s....A....h.......l....h....h......h.......l.......A..t......+......u......p.....s......l.............s........s....t..........p..........ll.+..s..A...PWpIVl..FSlGMYlV.VaG.L+N..s.G..l....T....p....hLu....t.....l....L....p....h.....l.....u......p.....t......G.......l....h.s...uh....h....G..hG...h.l.....s...A.h.LSul..h.NNh..P.....s.....V...............L............l........s........s.....l.........u.........l...s.......t........s.....s..........s.....s....s.....h....h..p.....c.......u...........h......l....Y..A.N.l....I...GsDLGP.K.....lT.P.I.G.SLATLLWL+..V...L.sp....K....s........h...p..I.o..Wu........Y...h...+s.G.l.l...h.T.l.P.l.Lhh.T.LhuLhh....................................................................................................	0	93	207	283
+1246	PF03960	ArsC		ArsC family	Bateman A	anon	COG1393	Family	This family is related to glutaredoxins Pfam:PF00462.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.33	0.72	-3.99	36	7591	2012-10-03 14:45:55	2003-04-07 12:59:11	10	18	3508	24	1253	4303	1099	107.40	26	86.65	CHANGED	YtsssCsos+KAhpaLcppslpaphhshhpsshscccLppllpphs.s.hcpllsp+upsa+pLs.....ls.pplot.scllcllhcpPpLl+RPIlhss......c+lplGass-plpth	......................Yt.PsCsos++A.h....p....h...L....c....p...........p....s....l..p.h.p.h.hph.h..p..ps...o..tcpLppllpph.......u.....s....hcpll..ss+u.p.ha+cLs.......hp...ss.l.ot..pp..h..l.plhhppP.tL.l+RP.Il.lss...........pp.h.p.l.Gasp-phtt.........................................	1	315	718	1014
+1247	PF01129	ART		NAD:arginine ADP-ribosyltransferase	Finn RD, Bateman A	anon	Prosite	Family	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.53	0.70	-5.25	9	454	2012-10-01 23:25:29	2003-04-07 12:59:11	13	17	114	8	209	503	14	201.40	31	63.26	CHANGED	LDMAssoFDDQYtGChccMct+.hPpL.+pEFstspthsssWcpAppcWp..........cR......psphs...........hPhsF+DpHGlALlAYTus....s.la+.FNpAlRpuGtS+pcYhtpFpFKslHFhLTcALQLLps....tsCpp.....VaRGl+.....GhRFp.st.GtoVRhGpFsSoSLp+psAp.....FGpsThFslcTChGssI+saShaPpE-EVLIPPaEsFpVsshpp.spu.spI.LcShs+pso	..................................................................................................shs.ssFDD...pY.sCtpp.h.tt..hs.p..h..hppEhttpp.htpsWppA..p.tWt.....................pp...........ttth............hP...s.h.pspau.l...AlhsYTss.....sslappFNpAl+....psutohp.pY.h.p.p...F...p..FKslHahLTpAlQlLpp.............thChp........V.a.RG..sp.............s....h.p..F....p......s..t...hG....t.p.lRhG....pFs...SoS...hpct.Ap................pF....G....p......p..........T......h...F......sl...h......T....C....h........G.......ss.......l...pta.S.hh...t.E..cEVLIPPhEhFpVhpht....ptt.ts.....l..L.t.tp.............................	0	25	49	112
+1248	PF02497	Arteri_GP4	Art_glycop; 	Arterivirus glycoprotein	Mian N, Bateman A	anon	Pfam-B_787 (release 5.4)	Family	This is a family of structural glycoproteins from arterivirus that corresponds to open reading frame 4 (ORF4) of the virus.	20.70	20.70	24.20	24.10	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.28	0.71	-4.35	3	241	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	9	0	0	248	0	176.90	80	99.36	CHANGED	MAuoLLFlLVGFcClLVSQAFACKPCFSouLSDIcTNTTAAAuFhVLQDIuCaR.HRsSAu.EtIp..KsPQCRTAIGTPpYVTITANVTDEuYLHsADLLMLSACLFYASEMSEKGFKVlFGNVSGlVAVCVNFT-YVuHVpp+TQ+.pLVlDHlRLLHFLTPSsMRWATVIACLFAILLAI	............................................................................MAAuhLFLLVGFcChlVSQAFACKPCFSSSLSDIKTNTTAAuGFsVLQDISCLR..HGsS...uS.......sIR...KsSQCRTAIGT..PVYITITANVTDENYLHSSDLLMLSSCLFYASEMSEKGFKVVFGNVSGIVAVCVNFTSYVQHVKEFTQR.SLVVDHV.RLLHFMTPETMRWATVLACL.FAILLAI.	0	0	0	0
+1249	PF01481	Arteri_nucleo	Arte_nucleocap;	Arterivirus nucleocapsid protein	Bateman A	anon	Prodom_2418 (release 99.1)	Family	\N	20.40	20.40	20.60	22.90	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.37	0.71	-4.00	4	700	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	11	6	0	662	0	110.20	70	93.69	CHANGED	SQpK+Kp....GNGpssN.QLsQhLuthl.tpttQs+....Gptp+KKpPtKP.HFPlAs.sDlRHchT.sERphChSSlQThFNQGuGosoLuDSGtlsaTVpF.LPTppTVRLIpsoAss	...................pQpK+Kp....GsGQPVN.QLCQhLG+hI.uQppQsR.....G....p....psKKKp......PEKP.HFPLAsEDDVRHHhT.oERpLCLpSIQTAFNQGAGTsoLSsSG+lSapVEF.LPstHTVRLIRVTuos...............	0	0	0	0
+1250	PF01606	Arteri_env		Arterivirus envelope protein	Bashton M, Bateman A	anon	Pfam-B_664 (release 4.1)	Family	This family consists of viral envelope proteins from the arterivirus genus; this includes porcine reproductive and  respiratory virus (PRRSV) envelope protein GP3 and lactate  dehydrogenase elevating virus (LDV) structural glycoprotein. Arteriviruses consists of positive ssRNA and do not have a DNA stage.	21.20	21.20	21.70	256.50	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.67	0.70	-4.68	3	333	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	8	0	0	354	1	211.30	78	82.56	CHANGED	MAcpCshFHhFL.CuFICYSsCCAVsANSoA..ThCFWFPLs+.GNTSFELolNYTlChhCsTsQAAtphLEPG+shWCRIGHDRCEEsDHDELsFslPsGhp.Lp.EGa.TSlYAWLAFLSFSYAAQFHPElFGIGNVSpVaVDh+HQFICA.HsG.NSTLscH.+NISAlaAlYYpHQlDGGNWFHLEWLRPLFSSWLVLNVSWFLRRSPAS+VSRRl	...MAsSCsaLHIFLpCuFL.YoFCsAVVANSNu..TaCFWFPLVR.GNFSFELsVNYTVCPPC.TRQAAuphLEPGRShWCRIGHDRCpEsDHDELGFhlPPG...LSSEGHLTSVYAWLAFLSFSYTAQFHPEIFGIGNVScVYVDIKHQFICA.HDGpNuTLPRH.DNISAVFQTYYQHQVDGGNWFHLEWLRPFFSSWLVLNVSWFLRRSPAS+VSVRV.	0	0	0	0
+1251	PF00951	Arteri_Gl	Arteri_glycop; 	Arterivirus GL envelope glycoprotein	Finn RD, Bateman A	anon	Pfam-B_425 (release 3.0)	Family	Arteriviruses encode 4 envelope proteins, Gl, Gs, M and N. Gl   envelope protein, is encoded in ORF5, and is 30- 45 kDa in size. Gl is heterogenously glycosylated with N-acetyllactosamine in  a cell-type-specific manner. The Gl glycoprotein expresses the  neutralisation determinants.	21.80	21.80	22.90	24.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.97	0.71	-4.68	11	8906	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	12	0	0	8965	0	171.80	75	86.54	CHANGED	.u.uhss.sss..p..p.h.ap.hhpphssTthhpphhsaulpohslh.hsp+lhphthLshsphl.hlshusl.uhhsahthchshossYuhsAlsALla....Flhp....ss..+.ChstRhhhst.ssFl.sscG+..lapscosl.lVc+sGpstVsGcLV.slKplVLsGpKAs.hstssAcpWp	.............hss...hsNAsss.S.SSHhQ.LIYNLTLCELNGTDWLs.s.+.FDWAVETFVIFPVLTHIVSYGALTTSHFLDTVGLlTV.STAGFhHGRYVLSSIYAVCALAALlC....FVIR....hA..KNCMSWRYSCTRYTNFLLDTKGR..LYRWRSPV.IIEKGGKVEVEGHLI.DL.KRVVLDGSsATPlTRVSAEQW.G................................	0	0	0	0
+1252	PF01097	Defensin_2	Defensin; Arthro_defensin; 	Arthropod defensin	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.12	0.72	-4.23	15	314	2012-10-01 23:31:40	2003-04-07 12:59:11	13	1	158	14	58	362	0	33.90	42	40.60	CHANGED	u.hh.lNcoACAtHCls+.G.p+GGYCsu..KsVClCR	............hhsh..spusCsuHChuh..G.p+GGYCss...ptlCsCh.............	0	23	27	51
+1253	PF04161	Arv1		Arv1-like family 	Wood V, Finn RD	anon	Pfam-B_9351 (release 7.3);	Family	Arv1 is a transmembrane protein with potential zinc-binding motifs. ARV1 is a novel mediator of eukaryotic sterol homeostasis [1].	20.00	20.00	20.30	21.50	18.20	19.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.82	0.70	-4.42	21	319	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	253	\N	217	304	3	176.80	27	62.27	CHANGED	hlCIpCspt.lpsLYppY...Ssshl+LTpCspCp.cssDKYlEaDsVllaIDll.LLKspAYRHLlaN.h......................................scacphh+lhllhlLhEsY...........LhWtppccp.pps..............................h.h..hhp.tshhhQhlhFhhthll....phhhhhhhhthhhhthhphs......................ht.thphlhhslLlSthuKlF.ILhlIWsas.shhuhtllpllshhphlpuL	........................hClpCsp..sppLappY...............s.t.......t.s.......l+lo.CtpCp.phs......DKYlEaD.lllhIDll.LhKspsYRHlLaN.......................................................t...p..hh+.lhlh.hl.L...h-.sY............lpWh.p.ppp.t.s..................................................hhp.....h.thhhh.h.hh..shh....ts.hhh....h.h.hht...hhhh...hh.h............................................t....l.hslhlu.......hKlh..l..h...h.lW.hs........hthhh...............................................................................................................................................................................	1	62	112	171
+1254	PF01731	Arylesterase		Arylesterase	Bashton M, Bateman A, Fenech M	anon	Pfam-B_2101 (release 4.1)	Family	This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity [1]. Human arylesterase (PON1) Swiss:P27169 is associated with HDL and may protect against LDL oxidation [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.71	0.72	-4.00	6	216	2012-10-05 17:30:42	2003-04-07 12:59:11	15	7	94	0	130	450	101	84.20	42	23.51	CHANGED	NDIsAVGP-pFYuTNDHYFscsaLhhLEhhLshtWosVVYYSPsEV+sVApGFsuANGIslSsDcKalYVA-lls+sIHlhcKHss	...................................NDIlAVGPcpFYATND..H.YF...ss...s...h...L..p..hl.E.h.a.L.s..L..t.......Wus.VVY...Y...S.......P...p....E......V...+...l...V...Ac...G...a...s.ANGIs......lSsD...p....K...alYVA-..lhs+pl+Vhc+p..........................................................	0	37	50	79
+1255	PF00858	ASC		Amiloride-sensitive sodium channel	Bateman A	anon	Pfam-B_415 (release 3.0)	Family	\N	23.00	23.00	23.10	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.65	0.70	-5.83	114	2052	2009-01-15 18:05:59	2003-04-07 12:59:11	19	39	116	15	1489	1878	5	339.30	17	78.79	CHANGED	FspsoolHGhpal..h.sspt..........hhc......................R.....................hhWhlhhlsulshhhh.hhphhppah.spPslssls..hht..pls.FPAVTlCshN.h.......chst..lpt....h.........tt.hthht.hh...t.................................................................................................................................................................................................................................................t.............................phshhphhpph........uhsh.c-hl....hpCpapup..........h..spp......ahp.......................................................................................................................................................................................h..h....hTp.hGh.CYoFNsttt...............................................................hps....ttsGhpsGLplhLph......p..pp-hh..sttss...............................................................................h....Gh+lhlHsts-hPhhsp........shtlssuh..p.shlulp.pphp.......pls.............sshpp.Ch.ss.....p..........h.h.....ttY.ohssChhcChsphhlcpCsCs.hhh................................tphsh..........Csh..pp...h.pC..........hpphhtphh......................tC..p.C.ssCsphpYs...hphohsphsspt...h......................t.p.s.t..ppshthlplaa...cphsa.pphccp.sashssLL...............................uslGG.hGLFhGsSlLollEllhah	.......................................................................................................................................................................................................................................................................................thtu...hh....t.....................................p...............................hhWhhhhhh....hhhh....hh....h.......h...............h................a....p..................h.................hthp..........................................ph...F.Pu.lo....lC.s..s.....h.......p.p.......ht..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ph.ph.h...th..........................t...h..t.p..h.h.....h.C........a...t..t..............h.......pp..........h................................................................................................................................................................................................s....G....C.hshN.................................................................................................................h..........su..t...............G...l..phhl.t.h...........t....p.p....h........................................................................................................Ghp.l.l...at.........tp..s......t..t.............hh.......h.......s........t.s..h......t.hp....h............................h...............h.tp....Ch.tt..............................................Y....o..t....sC..hpC..p...h..h..p.....C.tCh....h......................................t...............C.s......tp..............h..C..........h.........h...................................................................C..........C...sCp...................a.t.......h.t.h.t.......h......................................................................................t..t.t..h..hlplhhtt......h....h..pt..hth.thh.......................................................................................sshGu.hulhhGhShlshhEhh....................................................................................................................................................................................................................	0	637	750	1219
+1256	PF01671	ASFV_360		African swine fever virus multigene family 360 protein	Bashton M, Bateman A	anon	Pfam-B_1174 (release 4.1)	Family	The multigene family 360 protein are found within the African swine fever virus (ASF) genome which consist of dsDNA and has similar structural features to the poxyviruses [3]. The biological function of this family is not known [3]. Although Swiss:Q65137 is a major structural protein [1].	22.50	22.50	26.90	26.20	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.46	0.70	-4.95	14	126	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	11	0	0	100	0	205.90	43	60.99	CHANGED	EpT+cLCccLGAKptLpcpclhphFhc.lpcpKTuuNlILCHElFssN.PlLcsls.tcl+hhIahcLctl...h..hhsphohsphLsKYWYuhAlcasLpcAIpYFYQ+asHlppWRLhCALhaNNlFDLH-lYpp-+lcMDhsEMMplAC.h+DpNahTIYY.CalLGAsINpAMlsSlp.aN.................hsNlFFCIDLGAssFEEuhtlAtpcshphlhplLs	............cpT+cLCccLGAKptL.pcpclhphFhp.lpcpKTSsslILCHElFssN.PlLpsls.hch+hhIhhpLcth...h..hhsphohsphLsKaWYuhAlcasLpcAIpYFhp+atHhppWRLhCALhaNNlaDLH-hYppcclcMDhs-MMplAC.hpDtNahTIYY.CF.hLGAsINpAMhsSlp.as.....................hsNlFFCIDLGAssF-EuhtlAtpp.s.phlhphL.............	0	0	0	0
+1257	PF05170	AsmA		AsmA family	Bateman A	anon	COG2982	Family	The AsmA gene, whose product is involved in the assembly of outer membrane proteins in Escherichia coli [2]. AsmA mutations were isolated as extragenic suppressors of an OmpF assembly mutant [1]. AsmA may have a role in LPS biogenesis [1].	29.80	29.80	29.90	29.90	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	604	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.67	0.70	-5.90	12	3636	2012-10-03 05:41:17	2003-04-07 12:59:11	9	19	1503	0	623	2962	466	400.20	19	70.17	CHANGED	M+phh+hlhhlLlsLllll....hulhhhhssp.hpsplpp.Vuttsshplshcus.t............chhhP..plpLpslplussst.t.......hsplcplclsLushsLhspplplsplhLcssslpLsh.spsphshst.lp.pp.shss.............................ss.ph.luplplssuplhhpscstpphh..phslphpssslht...................................hshspstlsGphcpctpsh.s.lsssh.spsshst.thpst.t.......................hhtthuss.hphsshclhssplth.sshhhpsh..phsh.shpLphssht...s..thpt..th..htt.hh.sthsh..sPtslsltphstpaptupspsshth.p.th.h.............................................cptulsGht.ss.ssh.......h.pshPphp.pLphppLslschh.lpts.........pps.hptsshsstsssh.Lspcph.hshWps..............slp..hssspssa.spl.lscsthphpspsGhlpLsplpuslttGhlpusuplshsphstphplphsucsl.lp.Lhpth...hslpG.hslshshpGtutssshlhtslsGplchshssuthp...............................tt..tst.h.hph.phshshppGhlohs.h	............................................................................................................................................................................................................................................................................................hhhphhh.h...h...h...hsh..l.h.hl.........hhlh....h.h.h...p........p....h.p.sh.h.sp.........l...ptp..s.h..ht...h...p.u....t..................hth...h..P.......plhh..t.ph.....tl.....s.t........s.......t..........t.................hlphpphch.sls...hs.L.h....s....p....p....l.l.plhL.....ptsshp..L........p..t....s.....t........s...............h....t........p..p......t...ss..........................................................................t.................p.......h.....p.......l...s..t.h.h.s.....tuhl..h.p......p......s..p.........................p.h.p..h.......s........................................................................................................................................................................t.h...h.....t.........t.......h..p.........................................................h.......h.........th.........................................................................................................................................................................................................................................................................................................................................t............h.............................................................................................................................................................................................................t......t.ht.u......hh...t..............................................s...h.....pl.......hphtt............................................t..............................................................h....t..................ht.........................................ph...hphtt.h..h......t.h....h..pp....hth..p.......t.s.....htlp..hph..h...tG.ht......h..t...h.......p...................p...........................h..t..h..p.th..p..th........h.....t..................l..........................................................................G.....h.sh...h.phpu.....s.....hh...p.tGphth..ttt........................................................................................................................................................................................................................................................................................................................................................................................................................................	0	138	316	463
+1258	PF00733	Asn_synthase		Asparagine synthase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_443 (release 2.1)	Domain	This family is always found associated with Pfam:PF00310. Members of this family catalyse the conversion of aspartate to asparagine.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.71	0.70	-4.89	104	5876	2012-10-02 18:00:56	2003-04-07 12:59:11	16	41	3139	38	2130	12423	8100	248.10	24	44.92	CHANGED	plcchLpcuVppphh............uDlslGshLSGGlDSShlsulspc...........................................ts.lpoFoluapsss.................................................-hthActsApplusc..Hpphhlstp..-hhsh..l.cllhth-pPhs.....sshshshahhu+ts+...................ptspVsLSGcGuDElF..uGY....thhpps.thttht..hht.hpthhhh.h......................................................................................t......hh..hthh.st.L.t+sD+hsMutulEsRsPFLDccll-hshp.lPsphKh.psstt................................KhlLRcsh........pphlPcplhp.........RtK	...........................................................................................t.hpphl.ppuV...p..p..p.hh.....................uD..l..s..l.G.....s.h.L..S.G.GlDSS..l..l.s.u.l.s.pc...................................................................ht.......p..l....c..o.....F..s...l....u..h...p.s..s..s.........................................................................................-h.t.h..A..c..p.l....A..p.t..lGsp........Hpph....h......h..s..........p.................-.h...hpt.......l.p.h...l..h.t..h...-...p..s.....................tssh..s.h..a.h....h..s.c..hhp.....................................................................................tth.ph...s...L.SG-G...u....D....El..F...........u...GY...............................h.....h.t....p..t..........h...t......h.....t............h.....t...h...t.h....h.............................................................................................................................................................................h+s..s.+..h..........hu.h...u....l..........E....sR..s....PFL....Dp.chh.chs.hp....l.s.p..K..h...t.t.stt...............................................KhlLR.psh........................pt...h.l.P.t.p.lh.R.K......................................................................................................................................................................................................................................................................	0	735	1406	1834
+1259	PF03590	AsnA		Aspartate-ammonia ligase	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.80	21.80	21.90	24.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.47	0.70	-4.94	6	1603	2012-10-02 14:22:40	2003-04-07 12:59:11	10	4	1542	4	211	863	13	236.20	56	72.62	CHANGED	KoFIhQ.QppISFlKNTFTppLtE+LGllEVQGPILSpVGsGhQDNLSGtEKAVpVpVKpIPDAsFEVVHSLAKWKRHTLARasFupsEGLFVHMpALRPDEDsLDtsHSVYVDQWDWEKVIssGcRNluYLK-TVcpIYuAIRhTElAVsp+F.sltshLPcpIsFVHSEELVcRYPcLssKcREsAICKEaGAVFLIGIGGcLSDGKPHDlRAPDYDDWTT.SEstYKGLNGDILVWNslLscA	.....................l.p.Qpt..IsaVKspFpppLpccLsLlcVpAPlhscsGsGhpDNLs..GsE+sVphcVKs...l.P..D.u...p...hE..VVHSLAKWKRhTLucasFstGEGLYTcMpAlR.DEDp....LsslHSlYVDQWDWE+Vls.c.s..cRs..hshLKpTVcpIYtuI+tTE..........t........tV.ptca...s...l........t....s...h.....LP...-.pIpFlHSpELlsRYPDL.s.sKpREpAIsKE.hGAVFLlGIGGcL.s.DG+..HDsRAPDYDDWoo..................st...........u..........h.................GLNGDILVWNslLppA.......................	0	102	148	179
+1260	PF00026	Asp	asp; 	Eukaryotic aspartyl protease	Eddy SR, Griffiths-Jones SR, Finn RD	anon	Overington enriched	Family	Aspartyl (acid) proteases include pepsins, cathepsins, and renins.  Two-domain structure, probably arising from ancestral duplication.  This family does not include the retroviral nor retrotransposon proteases (Pfam:PF00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null --hand HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.08	0.70	-5.19	23	4762	2012-10-02 15:32:34	2003-04-07 12:59:11	18	56	583	656	3018	6175	72	282.30	24	71.72	CHANGED	pYhupIsIGTPsQpFsVlFDTGSSsLWVP...SspCsss........................uCpp+spacPSpSSTapps.Gps...a.sIpYGsGS.hsGhlupDTVslGGlslssQtFu.usp...su..h.....htuhhDGILGluasulssst...........hssVasslhsQullspslFSlYLspss....ttsGpllFGGlDsu+YoGslpalsVo..........ppsaWplslculsluss......shsssssp..............AllDTGToLlhhPsshlspltpslGAp.sp.................................................................................................t.....GtYslsCsshsphPslsFhls.Gtpaslssssalhpsssss..........ChhGhps......sssshaILGDlFlRphYsVFD.hsNsclGhAts	...................................................................................................................................Yhstltl....G...o......P..........s.....Q......p.h...p.lhh..D.T..GS.u...s.hW....Vs..........s......s..........................................................................................................s...............p.....t.....h.....a....s......s...p........t...S....s........o..h......p...........................s.....p.t............................h...pl...p......Y......u....s..........G..........s.......h......p........G........h......h..........s.......p.......D.............s..........l.............p...............l...............u..................s....................h..........s.........l...........p..........p............t.......t..........h.........u.........s......p..p.................s..........h.........................s.....h...s...G....l....l.Gl..u......a..s...p..h....s.sst..................................................h.shh..t..s.h....h..p..........p.....t.....h...l....s....p....s....h....F....u.....h.....h.........L.........s....p....ts.....................s.....G.....t...l..h...h.....G.....u......h...............D.....t....s......h..........a......p..........G..........p......l....t...a...h...s...l............................pt..s.h..a...p......l...p.....h.s...s.......l.....t..l...s..sp...........hh.s...t...t.....s....h.t...........................................................................sl....l..D....oG......T..o..h..........h.h..........h..P....p....p....h....h....p....t....l.........p...t....l....s..u.t........................................................................................................................................................................s..h.h..l..s..C.....s......t.......h......................h........s.......s....l...........s.....h..........t........h..........s...........s..........h...........p........h..s.....l........s.....s.......p......p.....h.....h.......h.....p.............t...t....t...................................C..h............s.h.s.........................................................t.......s........s.....h.........h.....l.......LG.s.s.F....lpp.h.as..l.a..D....h...t....p....t....p..luhA.............................................................................................................................................................................................................................	0	1115	1670	2449
+1261	PF02261	Asp_decarbox		Aspartate decarboxylase	Mian N, Bateman A	anon	Pfam-B_3879 (release 5.2)	Domain	Decarboxylation of aspartate is the major route of beta-alanine  production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	25.00	25.00	29.00	30.30	22.50	19.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.33	0.71	-4.51	163	2477	2012-10-02 17:45:13	2003-04-07 12:59:11	11	4	2416	51	550	1458	373	115.10	52	89.57	CHANGED	MhhphLKuKIHRAoVTpA-LpY.GSlTIDp-Ll-AAsIl.hEpVpIhNlsNGpRFpTYsItG-+GSGhIslNGAAARhspsGDhlIIhuYuthscpEh.cs.acPplVhlD.cpNplhc	...........MhpTMLpuKIHRApVTcA-LpY.GSloIDpDLL-AAsIlpsEpVpIhNlsNGpRFpTYsIsGE...RGSGlIslNGAAARhspsGDlVIIhoYuphs.-.-Es..+s..acPcVlah-.t.s.Nchh.c.........	0	193	390	489
+1262	PF00710	Asparaginase		Asparaginase	Bateman A	anon	Pfam-B_652 (release 2.1)	Domain	\N	22.50	22.50	22.60	22.80	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.03	0.70	-5.56	157	5341	2009-09-16 23:30:57	2003-04-07 12:59:11	15	27	3806	135	1165	3548	565	305.20	30	90.15	CHANGED	clh.......llsTGGTI...........uh.ttsspstthss.......ssptll...ptls....lpph...s.plps...............................................................................................................................................................................cthhs.lsSsshssppWhplupplppth...cs...cGhVlsHGTDThp.TAhhLshhl.ps.s....+PVVlTGu.+sh..........sphsuDu.tNLhsAltlAss............htGVhlshssc.......lhpupcspKsposshsA.F.pSsshsslu.hl...ss..plphhtp.hh.....................................t......................th...h.tthtsp.VsllthasGh.ss....phlcshl..ss.hcGlVlpuhGsGs......sssshhsslpcss.pp.G.......lsVVhsopshpGtVs...hshhusutplt.p...h.GslsusshssppAhltLhhhLupt..hshpcl.p	..........................................................................lhlltTGGTI........................uh..tt.s.s...p.s.....hhs.................tspsll......ptl.s......lp.ph.....s...pl.cs...............................................................................................................................................................................c..p.h...h.p...l.s.SscMss.ppWhplucp..I..pp..th...cp.........hDG....hVIoHGTDThp.TAhhLs..h....hl.....ps.........s..........KP..VV.lTGu.pP............s.p.hsuD.G...hNL.hsA....l...hlAus...........................t.......spG....Vhls.hNs.c............lhpupcs...........o.K.sp..os.sh.s.s.F.pSs..s.hs.sLu.hl........st...clth.h.pssht.........................................................tt..t..........................h.....s..p.......p.h...s.p...Vsllt..hY..sGh.ss................phlcsh........l....pt.......s....h...........cGl....lltuh..GsGN..............hstshhp....t....l.p....p....hh...p.p...G.......................lsV.Vhsop..........shsG.tss........th.....s..s..u..h.tlt..c.................h.Ghl.su...t..s..hssppAhhhLhhhLsp..ths.pth.....................................................................................................	0	339	683	964
+1263	PF01112	Asparaginase_2		Asparaginase	Bateman A	anon	Sarah Teichmann	Domain	\N	19.40	19.40	19.90	19.50	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.99	0.70	-5.71	7	2653	2012-10-03 21:14:07	2003-04-07 12:59:11	13	21	1641	72	1019	2127	867	259.80	32	88.17	CHANGED	sshhIs.lpG..utsslsps......hPh.hphht..hh+pssptuhcsLpuGsssLDsVE.ulchlEsp..chssGhGus.spsGpsph-AslMDGsshcsGAVuslp+l+NPIplARhVM-pTsHlhLsh-uAppFApspGhcp.s.ophtopp.hpchhtsppts....pl..D.osh.................l.ptpp...........hsTlGhVAlDspGplAuuTSTuGhs.KhhGRVGDSPl.GAGsYAschsu.soATGpGEslIRthsuhplsthMchGt...phsptshphlhcthPc.......hssGlIAlstpGcluhshss.uha..h.sAspss.h..Ysp.s...p	.......................................................................................t.............................................th.h.......hp...thh.p.........t..u.............p..h..L............p......t......G.........t.................s............A.l................D....s...Vttulphl...E.....sss....hhNuGhG.ushst.............sG.p.h.EhDA......s.l..M.............D..........G........p...........s..........h.......p..s......G............A.V......uu..l..p.pl..+N.Pl.....hA..........+.........h..........l..........h..............c......p...........s...........................H..............s.........h.........h.........sGp.......GA....p.p.a.A.h....t.t.....G..h...t...h....h....s............t.....h...................o...........................thp.ph.t....t....h.ttt................................t....t...............................................................ttp..............................................................hsTV.G.sVA..l.D.t.p.G.pl.A...A....uTSTGGhs.Kh.G.R.VGD............o..P.ll.Gu..G.s.............a........A........s.............s........t............s........s.....s.....o.....s..T...GhGE..hhh+h.....h..h.............u...hp..l...s.t...h...h......c.tt............th.t...ps.s..th.l....p..t..h.t........................stsull..s.l..st.pGp...h...s..hsh.ss......th................................tt.......................................................................	0	291	539	822
+1264	PF04958	AstA		Arginine N-succinyltransferase beta subunit	Bateman A	anon	COG3138	Family	Arginine N-succinyltransferase EC:2.3.1.109 catalyses the transfer of succinyl-CoA to arginine to produce succinylarginine. This is the first step in arginine catabolism by the arginine succinyltransferase pathway.	29.40	29.40	31.90	36.50	25.30	29.30	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.86	0.70	-6.02	71	1133	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	909	1	204	701	163	330.90	51	97.92	CHANGED	MhllRPlptsDlsuLhplAppo...GtGh.TSLPsscchLpp+Is+SppoFtspphspsupps...YlFVLEDocoGcllGssuIcAsVGhsp.PFYsY+lupllHsS......ccLslppphcsLsLssDhTGsoElCoLFLcssaRps..tsGcLLS+uRaLFhApapcRFu-pVlAEhRGlsD..-pG..pSPFW-uLuc+FFsh-FscADhLoGlssKsFIAELMP+aPIYVsLLsp-AQsVIGpVHssTcPAhclLEpEGFphpuYVDIFDuGPTlEAclcsl+oV+pS+thpVp...............tsu....pp..hLluNsphps.........FRAshsphths...s.splhlsscsAcsLplps.GDpVRhlsl	..........MhVlRPlcpuDlsALhpLAs...co...G.sGL.TSLPsNcspLusRIcRuhcoapuch...stuEpG...YlFVLEDoE...TGpVsGlsAIEsAVGLs-.PaYN.YRVuTlVHAS......+EL.sVaNslsTLhLSNDaTGsSELCTLFLcP-aRpp.....sNGhLLSKuRFhFhAuFR-+Fs-+VlAEMRGV.D..EcG..hSPFWpuLG++FFuhDFocADaLs.GsGpKuFIAELMPK.aPIYsphLSpEAQsVIG.pVHPpTtPAh.............s....l..LE+EGFcYcsYlDIFDGGPTLEC-l-clRulRcScllpVs.u.......ps..stsshss...hLVuNp.sacc.........FRssLscscss........sppllLostph-ALcsps.GDpVRlVt.L..........................................................	0	43	78	145
+1265	PF04996	AstB		Succinylarginine dihydrolase	Bateman A	anon	COG3724	Family	This enzyme transforms N(2)-succinylglutamate into succinate and glutamate. This is the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway.	20.10	20.10	20.10	38.90	19.60	20.00	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.46	0.70	-5.68	4	825	2012-10-01 20:45:11	2003-04-07 12:59:11	7	3	787	14	131	513	157	429.90	67	99.25	CHANGED	M.sAaElNFDGLVGPTHsYuGLShGNlASppNuttVSNPRtAAhQGLsKM+sLhDhGhsQuVLPPptRPssslLRpLGFSGSDEtVLppsA+-A.sLLuAsSSASsMWsANAATVsPSADTADGRVHhTsANLssphHRSLEussTtpsL+tlFsDEp+FAVHusLPtsuphGDEGAANHsRLsucaGssGVplFVaGR...-u..stsuRaPARQThEAspAlARLpGl..spslFAQQssssI-tGsFHNDVluVuNtpVLFtHppAFtcpsplLAEL+A+lsG.....hhlpVspsplulpDsVuSYLFNSQLLShs.DGpMhLllP.EsR-NstsWshlppLhuuDsPIscVKVhDLRQSMpNGGGPACLRLRVsLsEtEhsAlNPAhhhsssLhDsLscWV-RaYRDRLosuDLADPpLLpEuRpALDtLoQlLsLG.shYsFQ.....ss	..............MsAaEVNFDGLVG.THHYAGL..SFGNcAST+HchpVSNPRhAAKQGLlKMK.ALADhGFsQuVlPPHERPhlssLRpLGFoG.SDEQVLcKsARQAPchLSulSSASsMWsANAATVuPSADThDGKVHhTVANLNNKFHRSlEAssTculL+AIFsDEc+FuVHsALPpVAlLGDEGAANHNRLG.....GcYGcsGlQLFVYGR.....c-s..s...c...s...c..PsR.YPARQTREASEAVARLpQlsPppVlFAQQNP-VIDQGVFHNDVIAVSNRpVLFCHppAFs..cQppllspLR....s+lsG......FhuIEVPsspVSVuDAVuTYLFNSQLLSRs..DGSMh...LVlPpECR-csuVWsYLN.c.L.l.A.u.D.sPIs-l+VFDLRESMtNGGGPACLRLRVVLoEcERpAV..NPuVhMND.sLFssLNsWVDRaYRDRLTsADLADPpLLcEuRpALD.LTQlLsLG.SVYPFQ.c....................	0	24	49	91
+1266	PF04952	AstE_AspA	Aste_AspA; 	Succinylglutamate desuccinylase / Aspartoacylase family	Bateman A	anon	COG2988 & Pfam-B_15640 (release 10.0)	Family	This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.).	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.67	0.70	-5.53	33	2822	2012-10-02 19:46:12	2003-04-07 12:59:11	9	14	1568	43	782	2774	810	264.10	21	80.56	CHANGED	sG.slllouGsHGsEhsGs.llcclhpplsttp....hsuphhllshsNs.Ahpssp......Rhhs........psLN.....................RsFsGctpu............spsc+lAphhhtthh.sps-hslDLHouspuhshh.hshsshtss.h.....hphlpsh..shshsh.hpptsss............sh.phsspphut.ulolElGts..tshstptlsphttsltslLphl.uhhpsp......p.hthhphstpssptpp..u..sGhhchphplsspV-ttshhshshlhsphsscph.hpu...spsshllhhp.tshsttssslhhltpt	...................................................................................................tlhlsuu.lHGsE.hsu....h....t....hlpp.L.l..........p....pl..t.ttp............hh.u......t...h........l.......ll.slsNs.u.hp.ptp...............................................R.a.h.....................................pDhN..............................................R.h.F..s..G.p.ps...........................................s...hpph...s..p.th.......h..p.t......s.........t............p..s.....ch..h.lD...L...Hou.......h.....p..s.......t...h..h....h.....h.s.h.....h.s.h.p..sh.....h...............hth.ht.sh......sh.s..hl....h...ppt..s.ss.......................................s.h.hp.h.....s.....s.....p..p........h.......u......t............u..........h.o.lEhGts.........h.hstpthpt....h...ttsh.ht...hhthh...u.hhpst..................t.....h.h..t.hh.t....h...t...t.......p............................p..h..t..h.......t..hupp...stthp.h..s..l..h..s.....s..t......h.....hhs..........psthllh.p..shht.tsslhh....t.........................................................................................................................................................................	0	179	407	606
+1267	PF03115	Astro_capsid		Astrovirus capsid protein precursor	Mifsud W	anon	Pfam-B_2957 (release 6.5)	Family	This product is encoded by astrovirus ORF2, one of the three astrovirus ORFs (1a, 1b, 2). The 87kD precursor protein undergoes an intracellular cleavage to form a 79kD protein. Subsequently, extracellular trypsin cleavage yields the three proteins forming the infectious virion [1].	25.00	25.00	28.80	27.90	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	787	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.35	0.70	-6.28	11	1664	2009-09-13 08:26:15	2003-04-07 12:59:11	9	6	167	5	0	782	0	200.70	66	92.28	CHANGED	MASKSsKQVTVEV..NNNGRsRSKSRsRSQSRGRs+uVKITVNS+....s+uR.RQsGRsKhQSNQRVRpIVNKQLRKQGVTGPKPAICQ+ATATLGTIGSNToGsTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVVRlSLNPTSTPSSTSWSGLGARKHLDVTVGKNAlFKLKPSDLGGPRDGWWLTNTNDNASDTLGPSIEIHTLG+TMSSYpNpQFTGGLFLVELuSEWCFTGYAANPNLVNLsK........STDKpVsVTFEGSsGsPLlMsVPEsSHFARhsspRSohsToLuRAGtpooSDTVWQVLNTAVSAAELVTPPPFNWLVKGGWWFVKLIAGRsRoGs....+pFYVYPSYQDALSNKPALCTGuss.uuhRspssVtTTLQFTQMNQPShG+GEoPAThGRulPpP.........G-phpVlhTlussh...uPNssspQsWltKshsuPps........hslKIGpssp+YhshpGFT..........lsuV-WYTs-aQsupcP...........sPIsGlt....VhsssoKKADVYAhpQatsspTNs+pQlTolaLV+V...Tp...............sapVssahshhaptussss......ssslplRssTtssslpFppGpWYLlTsTsl+s.ussssGWlW.shELtsspsYhhDpshsHlIsP.Pssoplha-hhTulPpspsth.shppcss......................ss.pss-s.......hss-ETDs-sEosEDEsD..ElD....RFDL+soSsSEsED...ENsRVTLLsTLlNQGholpRAT+IopRAaPT.....s-+h+RuVahDLLssGlsPuuAWSHACcpARhhuh....pp..phS.GSRGHAE	............................................................................................................................................................................................................................................................................................................................................QRATATLGTl.GSNTSGoTEIEACILLNPVLVKDATGSTQFGPVQALGAQYSMWKLKYLNVKLTSMVGASAVNGTVlRVSLNP.TS.T.P.S.S.T.SWSGLGARKHLDVTVGKNAsFKLKPSD...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1268	PF04377	ATE_C		Arginine-tRNA-protein transferase, C terminus	Kerrison ND	anon	COG2935	Family	This family represents the C terminal region of the enzyme  arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway  of protein degradation by conjugating a destabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis.  N terminal cysteine is sometimes  modified [1].	25.00	25.00	25.30	25.40	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.53	0.71	-4.08	166	1296	2012-10-02 22:59:21	2003-04-07 12:59:11	10	12	1200	0	497	1090	425	134.00	35	43.75	CHANGED	pEpasLYp+YhpsR..HscGsMtsss...h...........ppappF...lpso.l.............................................................................................sohhlEap.............tsscLluVulsD...lLscGl.SuVYoF..aDP-..h.pptS.LGoaslLppIphucc............hsLsYlYLGYaIcsstKMsYKspapPhEl....LssspW	....................................................................................................................................................EpasLYp+Y.ptRH.tcushp..s.....t..............ppa.p.p.F...lps.s.h..l.............................................................................................s.o.hhlcah....................hss..cLlAV.ulhD...lLs.....c......u.....lSuVYoF.............a..D..P..D....h.pp..h.S.LGsaulL.p.pIphu+p................hsLtalYLGYaIcsstKMsYK.spapPtEhLsspt.............	0	143	288	400
+1269	PF04376	ATE_N		Arginine-tRNA-protein transferase, N terminus	Kerrison ND	anon	COG2935	Family	This family represents the N terminal region of the enzyme  arginine-tRNA-protein transferase (EC 2.3.2.8), which catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway  of protein degradation by conjugating a de-stabilising amino acid to the amino terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis.  N terminal cysteine is sometimes  modified [1]. In S cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important  for activity [2].  Of these, only Cys 94 appears to be completely conserved in this family.	21.10	21.10	21.10	21.50	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.91	0.72	-4.17	128	1240	2012-10-02 22:59:21	2003-04-07 12:59:11	8	8	1160	0	466	1031	317	77.30	35	25.38	CHANGED	pahhTsshsCuYLss................................+pppphhst...stthssphYspLhptGFRRSGshhY+PpC...psCsAChslRlssspFpso+oQ.+R	........................hhTsspsCuYLts...........................................cp.tcp.hst.........spt.......hs........sphYspLhptGF.R.RSGshhYRPtC....csCp.........uChslRlssscFpso+oQ+R..............	1	131	266	373
+1270	PF03078	ATHILA		ATHILA ORF-1 family	Mifsud W	anon	Pfam-B_2240 (release 6.4)	Family	ATHILA is a group of Arabidopsis thaliana retrotransposons [1]  belonging to the Ty3/gypsy family of the long terminal repeat (LTR) class of eukaryotic retrotransposons[2,3]. The central region of ATHILA retrotransposons contains two or three open reading frames (ORFs). This family represents the ORF1 product. The function of ORF1 is unknown.	19.50	19.50	20.20	20.50	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.52	0.70	-5.90	11	113	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	9	0	38	110	0	201.90	16	53.65	CHANGED	p++tElARGKRshps...........c.pl.pE-h-...-..stsst+tpph.p+tcc.TspEYh+hhp..cFhuTRYPp.pThtpLGlhcDVpalhppspLpshhuh.asuaccEolpFLSTLclcha....s.th-.cG.lGalpFhVhshpYplsIppLpphaGFPotpuhp..casp-ELpsLWhpIuushPhs.u+SKSs.IRsPVIRYhppslANshasRcpTGTVoNs-hEMID.ALptlL....RcTKsGpslcGDh.NDsshohlLL.HLhuY+paAhs.ppp.htGuLChGGllT.ILhussVslts.sh.P+hhDhcaLptpc.hphthssDhhha+Fpcs..t.u.hhLPs.chTpIhptpNI-FpPphphL...............s...ppp..hhptttpppl...-tpscpcph-...h-Ts.aHFpEah.Psp.pu+sluEsH+p.uhLp+WsphQcKlltphhKtl+hhpptlpshussp	..........................................................................................................................................................................................................................................................................................................................................h...................................................................................................................................................................................................................................................................................................................h.............................................................................	0	3	3	6
+1271	PF03477	ATP-cone		ATP cone domain	Aravind L	anon	Aravind L	Domain	\N	21.50	21.50	21.50	21.50	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.95	0.72	-3.55	133	9433	2009-01-15 18:05:59	2003-04-07 12:59:11	11	53	4693	82	2010	5803	3748	89.30	26	18.76	CHANGED	hhVlKRDG.pttsFchpKItpulpcAs.................t.h.....stp.p.spplspplhpp..lps...t....tl.ssccIp-hVpppLh.................cts.....thshs+thlh..YRph+ct	..........................hVlKRDG.p.p.psFst-KItpulh+As...........................................tt...ps.l..........sps.p...lp....p.l..sp.clp.pp....lps......t...............pl.sspcItphVhcpLh......................chs.....ph.s..hl+ht.sYRph+c.h...............................................	1	650	1237	1685
+1272	PF02222	ATP-grasp		ATP-grasp domain	Bateman A	anon	Pfam-B_157 (release 5.2)	Family	This family does not contain all known ATP-grasp domain members. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.12	0.71	-4.91	23	5314	2012-10-10 13:17:02	2003-04-07 12:59:11	17	15	3695	55	1212	22317	9135	171.00	35	44.36	CHANGED	l.pphGlssscahhlcsts...plppssppl....GhPsVlKtpphuYDG+Gphll+sps-lppuhcth......tstslllEcalsFctElollslR..shcGt..shhaPslcslpccGlh+hshsPAthstt...htppApplAc.clscpLsssGlauVEhFlh...sGc......lllNElAPRPHNSGHaTlsus	..........................................................................................................................h.cchuls.s..u...s...a...t..h.....l......s...o....t.p.........-.l..p....p.....s.....h....t......p....l...............G..h....P..s.llK.t.s.h.h.G.Y.D.G..+....G......Q....h...h...l.......+........s...t..p..-....l.p..t..u..h.phh.............................ssspsl.l.E.p.h..l.............s...............F...c.........h..................E............l..o..l.......l........s......s...R.................sss...G......p..............s......t........h.......a.......P.................s..............s......c............s........h.............p...........c...........s............G.............l.............h................p..........p..................S...........h.............s.................P......s....p.....h......s....s.t...................ht.p...p.A.p.p...h.Ap....pl.....s......p.....t.....L................s.........h.....s...G......l....h....u....V..E.h.Fls........p.G.s....................lllNElAPRPHNSGHaTlpu......................................................................................................	0	320	712	992
+1273	PF00217	ATP-gua_Ptrans		ATP:guanido phosphotransferase, C-terminal catalytic domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.	21.90	21.90	23.10	23.00	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.44	0.70	-5.05	115	3578	2012-10-02 17:21:26	2003-04-07 12:59:11	14	21	2750	104	545	2666	91	185.20	48	68.74	CHANGED	s.-s.chVlSoRlRsuRslcGhshPPph.ocp-pcplEphlpsALssl.....suchp.GpYasLss.....MostppppLl-cH......aLFpc..ss.hh.suthscsWPtuRGIahNcs+sFllWlNEEDHlRlISMppG...uslppVacRhspulptlE........cp.lcFuas-+LGYLToCPoNLGTGLRASVHl+LPtLuts....sc.hpphhpplpLphRGhtGEsoc.uhG...slaDISNppRLGhoEh-lVppl.hsGVpplIchE+ph	..............................................................................................sscallSoRVRsGRSlcGasFsPsh.T-t.p.h+E.hEpcV.sssLsuL.............cG-LK...Gsa..Y..P..Lou...........Moccs.Q..QpL.IDDH..............FLF...cE.......ss.hLp...s...A...sh.sRhWPsuRGIa..HN......-..s+....ohh.VhhNEEDHlRl.uMp.G....................hshtp...sapphsph...ptl-.........cth.a..a.pc....plGalh.....hCPoNlGTshRAuVhl...+l...PtLshp......tch.p.hh..t.ph...t......h..thR...Ghh......G....ts..........t.................................................................................................................	0	243	305	418
+1274	PF02807	ATP-gua_PtransN		ATP:guanido phosphotransferase, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain has an all-alpha fold.	25.70	25.70	25.70	26.10	25.60	25.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.48	0.72	-3.83	91	1908	2009-01-15 18:05:59	2003-04-07 12:59:11	10	20	1186	104	380	1509	23	67.60	62	24.46	CHANGED	schsp...ppslhpKaLT.-lapcL+sKcT..shGsTLscsIpoGl-Nss.....psVGlhAuDtEuYp..lFu-LFDslIc-hHsGa	.................................ppshhtphL..T...-l..acpL+s.+.pT..shGsTLhDVIQoGl-N.s........................psVGlYAs.DAEuYo..VFA-LFDPII-DYHuGF..................	0	158	187	276
+1275	PF01747	ATP-sulfurylase		ATP-sulfurylase	Bashton M, Bateman A	anon	Pfam-B_494 (release 4.2)	Domain	This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulphate [2]. ATP sulfurylase catalyses the synthesis of adenosine-phosphosulfate APS from ATP and inorganic sulphate [1].	23.40	23.40	24.40	23.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.33	0.70	-5.03	113	1308	2012-10-02 18:00:56	2003-04-07 12:59:11	12	15	1032	36	520	1170	549	214.80	37	43.51	CHANGED	asphpho....PtEhRphF.pc.pGWc..pVlAFQT.RNPhHRu.HEhLt+tAhct.h..s........ulLlpP.LlGtpKssDlssclRhcsacsllcp.Yh................PpspshluhhPhsM..RYAGPREAlhHAlhRpNaGsTHaIVGRDHAGlG..........s..aYGsa-AQclhcp..............ts-L..sIp.l.hcpshY.spcssphssh..........cssscspcp+.lplSGT...........clR.chLppGttsPshFsRPEVsclLhch.h	.........................sphphsPtEhRppF....cc....hshc....sVsAFQo.RNPlHRu.HchLhppAhct..h...s.........sLllpP.LlG.TKssDlPtcsRhcsacs.ll..cp.Yh................stspshlulhPssM..+....YAGP+EulaHAllR+Nh.GsTHaI.VGRDHAGsG...........DaYssacApclhsp.............hss-l..sIphl.FcpshY.sppspthhs...........cpsscs...pcpc..lhlSGT...........clR.chLRsGttPPshF.pPEVsclLhc..................................	0	179	315	435
+1276	PF00231	ATP-synt		ATP synthase	Finn RD	anon	Prosite	Domain	\N	22.10	22.10	22.40	22.40	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.76	0.70	-5.06	161	5197	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	4653	59	1266	3418	3462	281.00	34	97.64	CHANGED	AsL+-l+pRIpSlpsTpKIT+AMchV.AuuKl++Apcphpss+PYsp.plppllspl...htt.................................t.t..pshhttc.....pspcs.......hllllooD+GLCGuaNssll+tstphlpphpspt....ph...plhslGcKutsahp..p.h.............shp.lht.........phssls.cssshppsp.tlsppllpta...hpt..p.................................hDc..lhllYscF.hsslsQpspspplLP...............................................ttpttttttpsph.aEP..sscplLssLlspYlpsplapullEuhASEpuARMsAMcsATcNAs-hlpcLslpYN+sRQAuITpElhEIl.uGApAL	................................................................sh+-I+s+ItSlpsTpKIT+AMcMV.uuuKl++upcphpsu+PYup.phppllspl..sps..t.............................ph.p..pP.hl.ppR............psK+s.....uhlVloo..DRGLCGGaNsNlhKp...sh.ph..hp..p.hp...s.ps...............hp.h.pl.hslGpKGh..saap....p..t.............................uhp...lht..........phsslu....-pP..sh.p.cst..sl..s..pp.hlpta.....pps...p....................................hD....c...lallYs+F..l..s..s.h..oQpsphpplLPl....................................................t..t.s..p..t.tp..p.tph.sY...aE.P....s..s..cp...lLcsLLspYlpu.lYtull-uhASEpuARMsAMc........sATDNA......s...clIpcLsl.YN+uRQAuITpEloEIVuGAsAl.........................................................................	1	435	822	1071
+1277	PF05176	ATP-synt_10		ATP10 protein	Wood V	anon	Wood V	Family	ATP 10 is essential for the assembly of a functional mitochondrial ATPase complex [1].	21.90	21.90	23.80	24.70	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.42	0.70	-5.11	23	186	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	169	0	137	174	20	237.20	27	80.37	CHANGED	puh...........p..p....sspstptch...htLs+PlGh..PPp.s..pphs-spoLpp..htpDhhsh-K+tcRpKELst-hu+uhFt-hpsh+pppGKhFhuPsphFKpDKALYFPsht.....G+TL..............sus.....pssp.......shLcGKlSlVplFSoshuEppspoahp.....sshp-hhpps.t.........psQll-INl.-shl......KuhLl+lh.hsph+ppl.PtppapcY..Flsp.cs.hs.sl+Eplth.NshsGYlYLlDcps+IRWAuoGsAspcEhcsLh+sV+tL	..................................................hht...................t......l.+PlGh..sP..............s...pph..ptpohpt...........-hhs.-+....p..p+pccL..........t.....t...c.hs+.s...hat-hpsh.ph.p.pGKhFhuss.pha+t-puLaFPslh..............GpoL.............................ssp.......tshs...........shl..p...G.K.sSlVslao..o.hh.u-p.spoahp..........shhpphhpps......................tsQ.hlclNh.-shl......KuhLl+hh.hssh+..ppl..Ptppasp...Y..alsp.....ps.h...s.plR-plthhNshsGYlaLlDpps+IRWAusG.Aps..pEhcsLhpssptL....................	0	41	82	117
+1278	PF00895	ATP-synt_8		ATP synthase protein 8	Bateman A	anon	Pfam-B_446 (release 3.0)	Family	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.02	0.72	-3.76	66	6876	2012-10-02 21:03:42	2003-04-07 12:59:11	15	1	4964	0	41	6086	109	52.90	39	95.77	CHANGED	MPQLssss......Wahhllhhhlslhllh.hKlhsah...ssss......sppspppppssPWpa.W	....MPQLNPsP.......WFhIhlho..W...Ls.ah.hl.l..sKlhsas.....sNsP...........ssp...s.....s.pp....p.s.ps..W..sWPW.................................	0	8	12	21
+1279	PF00119	ATP-synt_A		ATP synthase A chain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.70	21.70	21.70	21.70	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.44	0.70	-4.84	30	17567	2009-01-15 18:05:59	2003-04-07 12:59:11	15	12	11908	3	1063	15216	2921	204.40	33	91.02	CHANGED	hslshpslhhhlhshllhhhhhhh..p......hPsphpshhphlhchlpshlpsphstps...httahslhholFlalhhsNhhG.LlPasFs................sTuclslThuLAlslaluhhlhGlppcshsha..phhls.hs...hlPhhl.hlEllS.hs+PloLulRLhuNlhAGcllltLlushh...............hhullshhlh.........lhhhhh-lhluhIQAalFshLshlYls-	.......................................................h........h...h.h.l.h.h.h.l..l...h.h........h....h....h....h...................................t......h..........lss...R....h.p.s..l.p.hhl.phh.s.p.p....l.h.t.s.l.s.tpu...........c.p.au.hh.......l..hoLhlFll...hhNhLG...L.l..P.Y....s...F.T................................................................................PT.opLu.hshuL.Als.l.W.lus.ll.hG.h+.p...p.s.....tts.h.......u+h..l....P.....p.......G......o........P..............h....................L....l.....P.......h....L....l...l......IE.sl.S.h.h.h.RPluLulRLhANlhAGHL.L.lp.Llushshs........................................h..h.h.u.l.l..s.h.hlh...............hhl.shLEl.hVuhIQAY.V.FslLhslYlp...................................	0	343	689	893
+1280	PF00006	ATP-synt_ab		ATP synthase alpha/beta family, nucleotide-binding domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	This family includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null --hand HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.34	0.70	-4.84	157	33595	2012-10-05 12:31:08	2003-04-07 12:59:11	20	61	14564	479	5203	24829	10876	206.20	38	47.96	CHANGED	TGl+sIDshhPlu+GQRhsIhussGsGKosLhtplspss....................p...ssss....lhsh..........................................................................................................................................................................................................................................................................................................................................................................................................................lGERscElp-hhcph..............hsp........tsh.......................p+.olllsususcss...ht+htushsu.hslAEaapp.pGp.cVLl.....lhDslTRaApAhREluhthuc..sPupcGYPssla...shlsclhERAGph...................................ttGSlTul.s...lhstusDh.s-PlsssshulhDGplhL..s+cLsppuha.PAIDl....htShS	.....................................................................................TGlKslD.h.l.s..P..h.u+G.t.+.hs.lh.G..ss.GsGKTs.lhh.-.lIpNh.................................s...psts..........sVas.u..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lGE.Rsc..Es.s....-lh.pch..................................ccs.......ss.h............................pcsslVhu....p..hs-P.s.......stRh.psu.hou............loh.A..EYFR............D......p............u..........p............D............V.Ll.....h.....hDsl....hRaspAhpElS....hl...Ls.....R...Pu.thGY.sslh.....tp.h.upL.ERhsps..........................................................ptGSlTul.s...lh.s.....us.Dh..ocsh.P..ssshuhh......D..u..phhL..s+pLt..tpGlaPAl.sshtSsS..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	1807	3311	4366
+1281	PF00430	ATP-synt_B		ATP synthase B/B' CF(0)	Finn RD	anon	Pfam-B_137 (release 1.0)	Family	Part of the CF(0) (base unit) of the  ATP synthase. The base unit is thought to translocate protons through membrane  (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits.  This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in Pfam:PF00006	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.33	0.71	-4.35	27	5963	2012-10-02 21:03:42	2003-04-07 12:59:11	13	9	4775	3	1260	3817	3365	130.10	24	75.06	CHANGED	sl.htllshhlllhlLhhhhhpsLtplLcpRcptItsslppAEcphpputphhtctcppLppA+tcApcllppApppupphtpphlspuppchcplhpsAtsclpppcppuhppL+pplssLulphspphlp	................................hhhphlsFl...l.ll.h.l.l.h..+..a..s....a....s.....s.........l.h.sh...l-cRppcIt.sslssA-cs.+.pc.u.p...th.t.pctpppLppA+tE.Ap....pIl......pp....Appcup....ph....hcp...hh....s....p....A...pp....-.tpc....l....h....ppA....ptc....Ip.tp....+pcAhppl+pp....V.upLulthAp+ll...............................	0	418	853	1083
+1282	PF00137	ATP-synt_C		ATP synthase subunit C	Sonnhammer ELL	anon	Prosite	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.05	0.72	-4.07	167	10204	2009-09-13 08:00:21	2003-04-07 12:59:11	16	24	5907	292	3091	5928	2123	66.90	28	77.67	CHANGED	hshl.GAGluhuluslGuulGhGhsuuushpuhu+pPc....lhsphllshuhsEshulauLllulll..lhs	.................thluA.uluhu.luulG.uulGhGhsuu.s..hlpu.....sARpP-.........................lhsphllshuhsEulul.a......ulllulllh......................	2	1106	1902	2580
+1283	PF01813	ATP-synt_D		ATP synthase subunit D 	Bashton M, Bateman A	anon	Pfam-B_1304 (release 4.2)	Family	This is a family of subunit D form various ATP synthases including V-type H+ transporting and Na+ dependent. Subunit D is suggested to be an integral part of the catalytic sector of the V-ATPase [2].	22.30	22.30	22.30	22.40	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.17	0.71	-4.75	114	1524	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	1253	6	536	1171	151	187.10	30	85.70	CHANGED	hpLhphKp+LphAp+GapLLKcKc-sLhhchhpllcchpch+pplpcth.pcAhtslshAph....utthhptlt.sstp..phplchppcNl.hGVplPhhchtp....................................ht.tsauhhssuspl-cuhcpapcslchllclAplEpshttLsp-lcpTpRRVNALEpllIPchcssl+aIphpL-EpEREphhRLKh.lKpp	....................pLtthKp+LpsAp+G+pLLKcKp-tLh.....hc......Fhpll.cchpch+pphpphh.ppuhtsh.shAph.....hutthhpplht.spp...phplchppcNl..hGVplPhhchhp.............................................................tts.h.au.h.hpsspplcc.shpphpchlphllcLAplc.....pshhhLscpIcpTpRRVNAL..............Ep..lh.IPphcpTlpaIphcL-EtERpphhRLK+lKp........................	0	199	334	452
+1284	PF00401	ATP-synt_DE		ATP synthase, Delta/Epsilon chain, long alpha-helix domain	Finn RD, Griffiths-Jones SR, Kerrison ND	anon	Pfam-B_114 (release 1.0)	Domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. This subunit is called epsilon in bacteria and delta in  mitochondria.  In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	24.60	24.60	24.70	24.70	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.35	0.72	-4.08	179	3444	2009-12-15 10:59:44	2003-04-07 12:59:11	15	6	3304	16	491	1953	627	48.40	37	35.06	CHANGED	c-IDhpcAppAhccA-ppLtpt..ps.ct....-hhcAphsLp+AhARLcshpth	........pDID.p+ApcAKc+AEpplppu....cu.ch...........-htcAphA.LpRAhsRlcshph.t................	0	154	303	405
+1285	PF02823	ATP-synt_DE_N		ATP synthase, Delta/Epsilon chain, beta-sandwich domain	Finn RD, Griffiths-Jones SR, Kerrison ND	anon	Pfam-B_114 (release 1.0)	Domain	Part of the ATP synthase CF(1). These subunits are part of the head unit of the ATP synthase. The subunit is called epsilon in bacteria and delta in mitochondria.  In bacteria the delta (D) subunit is equivalent to the mitochondrial Oligomycin sensitive subunit, OSCP (Pfam:PF00213).	20.10	20.10	20.60	20.30	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.29	0.72	-4.22	327	5637	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	5213	39	1228	3611	2337	79.90	32	59.02	CHANGED	lplclVoP-chlassp.lc.lhssuspG-hGlLssHsPllosLc.s.Ghlclp..ts...u......pp........phh.hlsGGhh-.Vp..s.splolLu-sA	............................hplplVoP.-.p.h.lasuc..Vc.lhls.....s..s.p.G.-lGlLPsHsPlloslc.s....G.h.l+lp....ts.....s...................pp.......................chl.hls.G.Ghl-lp..s.sp.l.o.lLA-sA......................................................	0	402	786	1040
+1286	PF04627	ATP-synt_Eps	ATP-synt_E;	Mitochondrial ATP synthase epsilon chain	Kerrison ND	anon	DOMO:DM04624;	Family	This family constitutes the mitochondrial ATP synthase epsilon subunit.  This is not to be confused with the bacterial epsilon subunit, which is homologous to the mitochondrial delta subunit (Pfam:PF00401 and Pfam:PF02823) The epsilon subunit is located in the extrinsic membrane section F1, which is the catalytic site of ATP synthesis.  The epsilon subunit was not well ordered in the crystal structure of bovine F1 [1], but it is known to be located in the stalk region of F1 [2]. E subunit is thought to be involved in the regulation of ATP synthase, since a null mutation increased oligomycin sensitivity and decreased inhibition by inhibitor protein IF1 [2].	20.50	20.50	21.80	20.90	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.35	0.72	-4.41	30	309	2009-09-10 16:25:20	2003-04-07 12:59:11	8	6	257	30	199	292	1	49.00	38	53.74	CHANGED	huuWRtAGloY.pYssIAA+sVRcuLKp-h+ssAt+Rsp.scl...............KascW.psG	................shWR.tAGloYh+YsslsAcsVRpuLKpph+spAt+Rst.spl...............+hscWpsG..............................	0	63	113	163
+1287	PF01990	ATP-synt_F		ATP synthase (F/14-kDa) subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes 14-kDa subunit from vATPases [1], which is in the peripheral catalytic part of the complex [2]. The family also includes archaebacterial ATP synthase subunit F [3].	23.50	23.50	23.50	23.50	23.40	23.20	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.29	0.72	-3.60	100	1179	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	1012	17	454	861	109	94.90	28	86.32	CHANGED	luVIGDc.Do.lsGFtLuGlsph.sh...........................ssc-lccslcchh.pcp-luIlllspclu......cc.lcctlcph..pp.....shPsll..pIPspptshshttss..lpt.lc+	..................................................luVIGDc......Do.lhGFpLhGlsthsst...........................stp-hccslcchs..............c............p-h.....u.........lIhlopplA..............pt.lpcplcpa..p.p.....shPs.ll...IPo+pt..sh.shuhsp..l.p.lc....................................	0	171	280	387
+1288	PF04911	ATP-synt_J		ATP synthase j chain	Wood V, Bateman A	anon	Wood V	Family	\N	20.70	20.70	23.30	22.70	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.74	0.72	-4.51	18	106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	102	0	80	91	0	52.30	45	78.02	CHANGED	+FPTPVlKPhhPFFsuGsllhYGlsphAss.hsocEFhNDPRNPpht..s.pttH	...KaPsP...lhKPhhPFFsAGhllhYGlsphtsAhhsocEapNDPRNPpht.tt.t...t................	0	23	47	70
+1289	PF02038	ATP1G1_PLM_MAT8		ATP1G1/PLM/MAT8 family	Mian N, Bateman A	anon	IPR000272	Family	\N	19.80	19.80	20.80	20.10	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.47	0.72	-4.95	23	266	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	47	12	108	287	0	49.20	42	44.01	CHANGED	scsp..-PFaYDYcoLRlGGLlhAulLFllGIlIlLS..t+C+C.phsQcp+phs	..........-c..-PFhY....DYpoLRlGGLlhAulLFllGI.lllLS......t.+.C....+C.phspp.pt..s.................	1	9	11	27
+1290	PF03899	ATP_synt_I		ATP synthase I chain	Finn RD	anon	DOMO:DM04622;	Family	\N	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.35	0.72	-3.84	154	2035	2012-10-01 19:47:47	2003-04-07 12:59:11	10	1	1796	0	377	1164	184	94.90	20	74.16	CHANGED	+lhhhphhlhh.lhsls...hhlh...........shp...huhu.....hlhGuhlullshhhhshps...httthst...pphht..........hhhG.thh+hhlshhhhhlshth...ttlph.lslhlGhh	..........................hhhphhlhh..lhslh...hhlh..............tht...hslu.....hllGshsuhlsshlhthhs....hhtt...thst....tpshh..........hhhG.phh+..h.h.hsllhhl.lshth...hphsh.lslhlGh....................	0	107	223	309
+1291	PF03154	Atrophin-1		Atrophin-1 family	Mifsud W	anon	Pfam-B_3427 (release 6.5)	Family	Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins [1,2]. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity [2].	26.00	26.00	26.20	26.60	25.30	25.80	hmmbuild  -o /dev/null HMM SEED	982	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.13	0.70	-13.94	0.70	-6.41	4	230	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	80	0	118	188	2	495.60	34	60.53	CHANGED	GKHSMRTRRsRGSMSTLRSGRKKQTsSPDGRsSPsNEDlRSSGRsSPSAAST....SSsDSKsEShKKssK...KIKEEAsSPhKosKR.REKsASDsEEs-RsouKKoKTQ....ElS+PsSPS..EGEuEGEGE.SSDSRSlN-EGSSDPKDIDQDNRSSSPSIPSPQD.NESDSDSSA.......QQQh.QsQtsPul.sPPusususus..........Ps.sPSusslPPQsSPsuupPss.s....tssshoLl.pAPoLHPpRLPSPHPPlpP.su..utssspPssPs..tPpusHHGPhPPhPHsLQs....uPl.L.aP..sPPQP.uL....upt.sP...sPupA..+o..t..suQssht.PpQPP...REQPLPPAP.uMPHIKPPPTTPIPQ.ss.QSHKHPsHlpuPoPF.pMsSNLPPPPALKPLSSLPTHHPPSAHPPPLQLMPQuQ.LpossAQPPVLTQSQSLPspuSspPpo............uh.phPsQssFspHPFhsushPuIsPPsssssShsussPsuSu..pPssS...shsuSsss......usssssLPsIQIKEEsLDEsEEPESPPPPPRSPSPEPTVVssPSHASQSARFYKHLDRGYNSCARTDhYFhPLuuSKLAKKREEAhEKAKREAEQKsREEREREKE+EK..EREREREREAERAA.............................KASSSuHEuRhu-sQLuussHhRsSFEsPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFaVsLNPsDPLLAYHMPGLYNsDPolRERELREREhREREIRERELRERMKPGFEVKPPELDsLHPSsNPMEHFARHGAlTlPshAG.PHPFAuFHPGLNPLERERLALAGPQLRPEMSYPERLAAERlHAERMASlusDPlARLQMFNVTPHHHQHSHIHSHLHLHQQDPLHQ........................GSuuP.HPL.VDPLsAGPHLARFPYPsGsIPNPLLGQ.PHEHEMLRHPVFGssYPR-L.suI.P.MSAAHQLQAMHAQSsELQRhAMEQQWLHGH.HhHGG.LPSQEDYYphhhppus+pL	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hS....P.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	12	22	62
+1292	PF03769	Attacin_C		Attacin, C-terminal region	Finn RD	anon	Pfam-B_2791 (release 7.0)	Family	This family includes attacin, sarcotoxin and diptericin.  All members of this family are insect antibacterial proteins which are induced by the fat body and subsequently released into secreted into the hemolymph where they act synergistically to kill the invading microorganism [1].	28.80	28.80	29.70	28.90	26.90	28.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.28	0.71	-3.94	24	176	2009-09-10 15:59:06	2003-04-07 12:59:11	10	3	48	0	58	196	0	106.40	31	59.05	CHANGED	hssa..GsplsssupsNlFpsssHcLsAsAFto+shss...ps.pFsphGGGlsY.atsthGAohusu+pshhs.sshulsG+hNlapSss..oSLDhsuGas+ahussacsSphp.shGhsho+pF	......................................thts.hptthpsslhps.t.cslssps.a..topsh.t.......app.GuGlsh.hh.sthuAuhusuphsshs.pplslsG+sNLWpSssttopLDhsGuhu+ahuGPassptssausGhshoapF..........	0	12	17	40
+1293	PF03472	Autoind_bind		Autoinducer binding domain	Bateman A, Holden M	anon	Bateman A	Domain	This domain is found a a large family of transcriptional regulators.  This domain specifically binds to autoinducer molecules.	21.00	21.00	21.00	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.69	0.71	-4.91	188	2219	2012-10-02 14:34:25	2003-04-07 12:59:11	10	9	1181	48	438	1549	74	144.40	20	58.87	CHANGED	shpp.lhphlpphhpthGacp.hsas.......s.ttstsshhlhs.saPs.sWhp...pYhppsahthDPllptsh...psht.P.hhWsch.ht...........stttp..phhppAppaGl.psGholPl+sssuph.uh..l.ol..stsppshs.hp.....pttplphluhhhapph	.................................................t..pplhp.lpthspphuachhshs...............hhhshshstschh..hhs..sa.P.t..sWhp.......tYppp.sahtlDPllphst....psps..s..hhWscthhptt......................tlhp.t.A.p.p.a.....G..l..ppGl...ohsl...h...s...ss..ss....h..uh..L.Sh....upsstp.ssht......hphphphls..h....h.................................................................	0	65	185	288
+1294	PF00765	Autoind_synth		Autoinducer synthetase	Bateman A	anon	Pfam-B_881 (release 2.1)	Family	\N	20.10	20.10	20.20	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-5.04	13	807	2012-10-02 22:59:21	2003-04-07 12:59:11	12	2	478	5	184	757	67	174.20	26	85.33	CHANGED	sashhscs+..-ElFsLRKcTFKDRLcWsVpCpsGMEFDpYDNpsTTYllGlp-.spVlCSlRFI-s+hPNMIT.GTFtsaFsclslPc.GsalESSRFFVD+u.Rs+sllG.sptPlothLFLuMINYA+spGYcGIhTIVS+sMhpILKRSG.WpIsllppGhupcpEplYLlaLPsDc-spctLh	.......................................pphhph...Rpcl....F..h-....+Ls.W...c....l..s...s.....t.....s...u...h..E.hDpaD.s.s.s.sh..Yl.l...u.h.s..c.....up.lhGs.sRLL.......P..T.......s.....t......P.....h.....h.....L.......p....ss........F........s...p.......L...h.......t.......s........h........s.......h.....P....p.......s..s.s...lWEhSR.F.s...l..stt...h........s.......tt.............h..................s...s....t.........t...................................hs...h..h....lhhu.hlpauhppGhppllsVs.s.hs.h.t+lh+RhG.hthphlG..s...........t..t..p..hhhhhh.hs........h............................................................................................................................	1	22	84	121
+1295	PF03987	Autophagy_act_C	Autophagy_C; 	Autophagocytosis associated protein, active-site domain 	Finn RD, Wood V, Coggill PC	anon	Pfam-B_10019 (release 7.3)	Domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The cysteine residue within the HPC motif is the putative active-site residue for recognition of the Apg5 subunit of the autophagosome complex [2].	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.04	0.72	-3.79	57	558	2009-09-11 22:59:56	2003-04-07 12:59:11	10	8	307	1	391	549	6	65.50	35	23.68	CHANGED	hIsYsphYpsPplaltGas.........p.st.psLs.ppha...-Dlsscatp+T....................lTh-paPh...............hsh...hhslHPC+	.............................aIsYsp..hYpsP+LalhGas........................p..st...pPLsscp...h...h......ED......l..s...t-atp+T............................................lT.h-pHPh.....................hshs....hholHPC+.................................	0	124	202	314
+1296	PF03986	Autophagy_N		Autophagocytosis associated protein (Atg3), N-terminal domain 	Finn RD	anon	Pfam-B_10019 (release 7.3)	Domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the lysosome/vacuole.  Atg3 is a ubiquitin like modifier that is topologically similar to the canonical E2 enzyme [3].  It catalyses the conjugation of Atg8 and phosphatidylethanolamine [4].	20.30	20.30	22.40	25.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.05	0.71	-4.43	29	337	2009-09-11 23:00:31	2003-04-07 12:59:11	8	5	293	3	233	333	4	156.20	35	49.50	CHANGED	tl+ush.sltEaLTPVh+pSpF+pTG.ITPEEFVtAGDaLVa+hPTWpWu.susps+h+saLPtDKQFLlTRsVPCa+Rspphtts......ttt-cllc-p-t...........D..-GWVcTpthssttt.............psschcsls-hsstspp....................ptp-p----hs	...................h.l+uphhsht-hlTPlh.+pSpF+cTGhlTPEE.FVtAGDaLVa+hPTWpWs..s.....us..s......+t+sYLP.tsKQFLlTRs.......VPCh+Rspphths...........tpt-t.llc..-.s.ps...........................-.sG....WlpTtt.ss.ttt...................t.tt..c.sl....s-hs..spp.................................t.....t......ttt..............................................................................................	0	78	126	188
+1297	PF02309	AUX_IAA		AUX/IAA family	Bateman A, Mian N	anon	Pfam-B_801 (release 5.2)	Family	Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin. Some members of this family are longer and contain an N terminal DNA binding domain, such as Swiss:O64965. The function of this region is uncertain.	22.70	22.70	22.80	23.00	22.30	22.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.72	0.70	-4.59	56	1709	2009-01-15 18:05:59	2003-04-07 12:59:11	11	17	106	4	612	1704	1	179.60	27	48.17	CHANGED	LsLctT.E.........LR..LGLPGstt.t................................ptsstsssKRu..Fu-..................................................sstttpssssspppp........psspsP.............................sK.......AQVVGWPPVRSaRK.Nsht....................................ptpst..............haVKVSMDGAPYLRKlDL+hYpuYpELssAL-cMF.usF.olG..............E.phh-hhsGS.EYVPTYEDKDGDWMLVGDVPW-MFlcSCKRLRIMKuSE....AhGLusps	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.h.s..sh.....ssl.p..s.hp..p..s.ht.........................................................t.....t...............thaV.K.VpM-GsshhRKlDLph...a......suYp-LtpsLp.cMF...........sh..t................................................t....hc.......hp.ts...cahlsYc.D.c.....-GDhMLVGD.sPWp...........F........hpss...++l.+Ihptp-.h....................................................	0	67	360	485
+1298	PF02041	Auxin_BP		Auxin binding protein	Mian N, Bateman A	anon	IPR000526	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.07	0.71	-4.81	4	80	2012-10-10 13:59:34	2003-04-07 12:59:11	11	1	41	8	18	138	46	144.30	65	86.11	CHANGED	AupCslpGLPlVRNIS-LPQ-NYGRsGLSHhTVAGSlLHGMKEVEVWLQTFAPGScTPIHRHSCEEVFVVLKGpGTLYLu.SSHuKaPGpPQEFsIFsNSTFHIPVNDsHQVhNTsEHEDLQVLVlISRPPlKlFhY-DW.MPHTAA+LKFPYYWDE-Chpssp...DEL	........................................t.ss.ps.slVRsISch.QssYGt.GLSHhT..lAGu.lh..HGhKEV.EVWLQTFuPG.s.pTPIHRH.S.C.E..EVFVVLKG....sGTLYL....u....sSH.t....Ka.P.GcP.pE....a.sIFsNSTFaIPVNDsHQVWNTsE+EDLQVLVlISRPPlKlF.hY-DW.MPHTAA+LKFPaaWDEpCh.ts.....E...................................................	0	5	12	16
+1299	PF02519	Auxin_inducible		Auxin responsive protein	Bashton M, Bateman A	anon	Pfam-B_1263 (release 5.4)	Family	This family consists of the protein products of the ARG7 auxin responsive genes family none of which have any identified functional role. 	20.90	20.90	21.10	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.50	0.72	-3.95	112	1334	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	37	\N	887	1284	1	94.40	31	75.65	CHANGED	hstphpth.tttp.......thh.tts.tth...........................hP.+GahsVYV........Gc............tpp.RFlVPlsaLs+PhFppLLcpAcEE.F.Gasp...tGs..LsIPCcts.hFcp.lhshlp	.........................................................................tt.......................................p..........................sslP...KGah.sVYV...........G-.............ptc..RFllPl.sYLspPhFppLLppA......EE..E...F.G.asp....tGs.....L.slP.C.cts.hFpplhphl.p......................	0	98	600	754
+1300	PF03708	Avian_gp85		Avian retrovirus envelope protein, gp85 	Finn RD	anon	Pfam-B_3651 (release 7.0)	Family	Family of a vain specific viral glycoproteins that forms a  receptor-binding gp85 polypeptide that is linked through disulfide  to a membrane-spanning gp37 spike.  Gp85 confers a high degree of subgroup  specificity for interaction with distinct cell receptors [1].	21.10	21.10	24.50	23.70	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.85	0.70	-5.14	5	283	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	22	0	0	304	0	223.70	64	47.01	CHANGED	LNVSLWDEPpELQLLGSQSLPNlTNITplou..V......sGGClGFsP..pusGlY.GWsRctlo+aLLccPh.pPaFspsSNSo-PFTVVTADRHNLFMGSEYCGAYGYRFWcMYNCSQoRps........Ys.C..Gcssu..sG.PEsWCsu+GGcWVNQSpEhNESEPFSFTlNCTGSsLGNsSGCCGcssTILP.GAW.lDSTQGSFTK..........PKALPPAIFLICGDRAWQGIPSRPVGGPCYLGKLTMLAPNHTDI...LKlLuNSSRTGIRR.KRS	....................LNTTLPWDPQELDILGSQMIKNGTsRTCVTFGSVCYp...tNtSpVCHsFDGNhNGTGGAEAELRDFIsKWKucD.LIRPYVNQSWTMVSPINs.....ESFSISSRYCG.........FTSNETR.Y.........Y+....GshSs........WCsSKGGcW.........SAGYSNGTpCSu....NToGCGGNCT.......uEWNYYAYGFTFGKpsElL......WNNGTAKALPPGIFLICGDRAWQGIPpNALGGPCYLGQLTMLSPNFTTW.....hTYGPNI..TGHRR.+R....	0	0	0	0
+1301	PF01382	Avidin		Avidin family	Bateman A	anon	SCOP	Domain	\N	20.10	20.10	21.90	21.20	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.64	0.71	-3.80	15	142	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	81	454	71	247	4	107.70	29	48.71	CHANGED	s..slpGsWhNchGSshtIss..susGtloGTYhossusssstspsp..slsGah.......s..t..ssoshuFoVsW....spssSsTsWoGQshls..supstlpThWhLsssssssp..WpuspsGtDsFTp	...............................shpGpWhNchGS..phpIp.....pssGtlsGsYhoslsps.t....s...ss.....lsGhh.................stssl..uFoVpW..........sphpShT..sWsGQshhs..supphlpThWhhspts.sstp...p..WtuhpsGtDhFs...................................	0	39	42	61
+1302	PF03377	Avirulence		Xanthomonas avirulence protein, Avr/PthA	Mifsud W	anon	Pfam-B_3936 (release 6.6)	Family	\N	23.10	23.10	23.10	23.20	22.30	23.00	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.43	0.70	-14.25	0.70	-5.74	2	801	2012-10-11 20:00:59	2003-04-07 12:59:11	8	12	45	7	116	807	9	173.70	53	73.42	CHANGED	LsssQlltIAppGGhpAlEsVpthhssLsts..sLT.tQVVAIASNIGGKQALETVQtLLPVLCQsHGLTPDQVVAIASN.................................................................................................u.....GGKQALETVQRLLPVLCQsHGLT.-QVVAIASN.GuKQALETVQRLLPVLCQsHGLTP-QVVAIASp.GGKQALETVQRLLPVLCQsHGLTPpQVVAIASNhGGKQALETVQRLLPVLCQAHGLTP....................................................................pQVVAIASpsGGKQALETVQRLLPVLCQsHGLTP-QVVAIASNGGGKQALETVQRLLPVLCQsHGLTPpQVVAIASN	.....................................................................................................................................................................................................................................................h.hlp.+.LhP..V...Lsps.HuLT.tQVVAIASp.GG...KQALETV.Q.R.LLP..VL.CQ.s.HGLTPcQVVAIASpsGGKQALETVQ.R.LLP..VL.CQ.s.HGLTPsQVVAIAS..N.GGKQALETV.Q.R.LL.P..V.L.CQ.s.HGLTP-QVVAIASpsGGKQALETV.Q.R.LL.PV.L.C...Q.s.HGLTPsQVVAIAs..psGGKQALEoV.p+hL.Ps....................................................................	0	5	22	22
+1303	PF03591	AzlC		AzlC protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.80	22.80	22.80	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.64	0.71	-4.25	162	3558	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	2883	0	690	2484	1687	141.30	28	60.12	CHANGED	lPl.hluhhshGlsaGllu.spsGlohhpshhhShllaAGuuQFlslsllss....uu...s...hhslllsshllNhRHllauholsshhp..t..hshht+hhhuahLTDEsaAlshs.phtp.ttttt.............hahhGhs..lh.hahsWhluohlGslhGshls	................hPlslualslGluaGl..h.u.spt.Ghohhpsh.hhShllaAGuuQFlhlu.llsu....uu....s............lhsls.loshhlNhRahLhuhultshhp....t..........hshhpp.hhhuahlTDEsaulshs.ph.sp..ppttt.................hahhGlsl.ssahsWshuollGuhhGshl............................	0	197	409	559
+1304	PF02216	B		B domain	Bateman A	anon	Pfam-B_1782 (release 5.2)	Domain	This family contains the B domain of Staphylococcal protein A, which specifically binds to the Fc portion of immunoglobulin G.	22.40	22.40	22.90	22.40	21.50	22.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.29	0.72	-4.20	6	1484	2009-01-15 18:05:59	2003-04-07 12:59:11	11	69	165	21	12	1155	0	53.40	62	43.70	CHANGED	ppspasc-QQNAFYplL+hPNLsEEQRNGFIQSLKDDPSpSppVLuEAKKLNDu	....s.sNpasc-QQNAFYEILphPNLNEEQRNGFIQSLKDDPSpSsNl.LuEAKKLN-u..........	0	8	8	12
+1305	PF04182	B-block_TFIIIC		B-block binding subunit of TFIIIC	Wood V, Finn RD	anon	Pfam-B_68239 (release 7.3);	Family	Yeast transcription factor IIIC (TFIIIC) is a multi-subunit protein complex that interacts with two control elements of class III promoters called the A and B blocks. This family represents the subunit within TFIIIC involved in B-block binding [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.10	0.72	-4.13	35	324	2012-10-04 14:01:11	2003-04-07 12:59:11	7	4	262	0	222	703	46	74.90	27	4.73	CHANGED	sshpaplLptIApsRhpGlhph-Ls.phss..pDsRslhh+hcpLpctsLIs+psl...................................ptpstposllhLp+Fhpp	.....................s..hpaplLptlu..p.u.Rh.pG..h..h.Qp...-Lt..phhp.....hDs+plhhph+tLpcpGLIs+psh....................................................................................................ptpt......tpo.t.l.lhLp+Fh..t...........................................................................................	1	65	124	181
+1307	PF02246	B1		Protein L b1 domain	Bateman A, Mian N	anon	Pfam-B_3438 (release 5.2)	Domain	Protein L is a bacterial protein with immunoglobulin (Ig) light  chain-binding properties. It contains a number of homologous b1 repeats towards the N-terminus. These repeats have been found to  be responsible for the interaction of protein L with Ig light  chains [1].	25.00	25.00	26.40	43.00	24.60	23.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.31	0.72	-4.15	3	19	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	2	23	0	33	0	69.50	78	44.52	CHANGED	TPE.PKEEVTIKsNLIFADGoTQTAEFKGTFAEATAEAYRYADLLuK-NGEYTADLEDGGYTINIKFAGK	TPE.EPKEEVTIKANLIaADGKTQTAEFKGTFEEATAEAYRYADhLtK-NGcYTsDltDtGYTlNIKFAGK............................	0	0	0	0
+1308	PF03483	B3_4	S3_4;	B3/4 domain	Bateman A	anon	Pfam-B_1005 (release 7.0)	Domain	This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.	23.30	23.30	23.40	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.76	0.71	-4.80	308	5864	2012-10-01 21:04:40	2003-04-07 12:59:11	12	45	4697	27	1517	4739	2917	167.50	30	24.80	CHANGED	ssspahu+.llcslp.hssSP.WhppR..LhtsGlRs.INslVDlTNYlhl-hGp.....PlHAFDhc+l....p.........s.plh.VRh.Ap.su....E.plhsL..Dsp.chpL.ss...........................stlV.Is...D......s......p.p.sl.ulAGlMGGtpSpls.p.........sTpslhlEuAhFsshtlttsu+phs..lpo-uShRFERG.lDsphsthAhccAspLlh-ls.G	...............................................................................................................sstahs+.h.lc.slp.hts.o....P.W.hpp+....L.hps....G.h.....Rs...IsslVDloNYlhLchGp.....PhHuaDh-cl.p..........................................G.slh..VRh.Ac..pG............................E.phs.sL..D.sp...-tpL...ss.......................................splV.Is....D........s.......................pp..sl..uluGlhGG..p.po.t.ls.p........................pTps.lllEsAhFss..h.s.lttp..u+.pht....lpo-.uu...RaE+G.l-..t.h....uhphAstLl.phs.............................................................	0	509	955	1269
+1309	PF03484	B5		tRNA synthetase B5 domain	Bateman A	anon	Pfam-B_1005 (release 7.0)	Domain	This domain is found in phenylalanine-tRNA synthetase beta subunits.	24.10	24.10	24.10	24.10	23.20	24.00	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.33	0.72	-4.15	85	4895	2009-01-15 18:05:59	2003-04-07 12:59:11	10	18	4795	27	1299	3944	2191	69.60	33	9.04	CHANGED	tptlplshpplscllG...........................h..plstppltp...hLpplshpsph....................spsthpVpsPsaR..hDlppphDllEElsRhhGa	......................................t...lslphscls+ll.G.................................................h.....cl.s.tp....p.ltc...lL.p+LGhp.lpt.....................................................sssthp.V.ssPoaR..hDl....p.h.ct...DLlEEVARlYGY..............	0	443	837	1100
+1310	PF01603	B56		Protein phosphatase 2A regulatory B subunit (B56 family)	Bateman A	anon	Pfam-B_984 (release 4.1)	Family	Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also Pfam:PF01240), this family is called the B56 family [1].	25.00	25.00	25.40	25.10	23.40	24.40	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.30	0.70	-5.87	54	1081	2009-01-15 18:05:59	2003-04-07 12:59:11	15	15	292	10	639	990	15	337.90	49	73.42	CHANGED	.L.P.hp.csssscppsLFlpKlp.CshlhDF.sD.....ssp-hppKch.KppsLp-ll-hlsss.p........stls-shhstlhpMlusNlFRsl.......Pshsp.t........hss---ps...hh-suWP...H...LplVY-lhl+alpssshssp.hptalspsFlhpLLsLFcSpDsRER-hLKshLH+lYuKFhshRshIRpsIsslhh.................calh.....csppasGluELLElhuSIIsGFulPLKcEHphFhh+sLlPLHpscslshYatpLshslspFlcKDssLsp.llctLL+aWPhosopKElhFLsElccll-hhpsspFpphhhsLFpplucC.lsSspFpVAE+ALhhWsN-tlhsLl.....p..pNsphlhPllhsuL.csucpHWNpsl+shshssh+hhh-hssplFpc.http......hpppppccpppp...pp+cppWpplt.chAt	.......................................................................s.hc.-s.sst-p.pLFhpKlp.CshlFDF..D.........................shtc............h+.KEl.KRtsLtEhl-al.......sps..p............shlsEshhschl.pM..h..........u..hNlF.Rsl...............................PPssssp..........................aDsEEDEP............slEsuWP...H..................L.Q.....lVYEh.....FLRFlpS..-hpsp......lAK+YIDp.pFV..L.....p.......LL-L.FDS.EDPRERD...aLKThLHRIYGK.FhshRuaIR+pINNlFh.................c.FlY.....ETE+aNGlAELLEILG...........S...II..NG..............FALPLKpEHK.FLh+lLlPLH..........KsK........s..........Lu..hYHs....QLu.Y.CllQFl.EKDspLs-................Vl.h..GLL+aWP...t...TpS.K..EVM..FLs.ElEEI.L-...l.....hc.P.........s.p....F........Kl..PLF+QlA+C.lsSsH.F.........Q........V.AERALah.WNNEalh.s...Ll.......................p..cNt...th...IL..PI.hFsuLh.cso+p.HWN..p.s.l.....huLhhNshKhFhE.hs.pLF--.hstp......aptcctp........tp....p...........tpRpphWtplp.p..................................	0	209	349	494
+1311	PF02043	Bac_chlorC		Bacteriochlorophyll C binding protein	Mian N, Bateman A	anon	IPR001470	Family	\N	25.00	25.00	28.60	28.40	24.90	17.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.79	0.72	-4.19	12	34	2009-09-11 07:33:55	2003-04-07 12:59:11	12	1	21	1	24	32	0	77.10	52	97.47	CHANGED	shuGAFopuAtAYGRhlEVFlDGHWWVVGDhLENlGKoTKRLssNAYPalYGG..uuuuul+GSSPphuGYApPoKclcpRFpc	.s..uGsFTchhuAhGRIhEVhl-GHW.sVG.hh-ulGKuThRlspNAYsphhGG....usuLRGSSPpsSGYAhPoKtlcS+Fs...........	0	4	5	18
+1312	PF00216	Bac_DNA_binding		Bacterial DNA-binding protein	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.70	0.72	-3.96	158	11816	2012-10-02 15:10:05	2003-04-07 12:59:11	16	10	4455	45	2522	6533	4975	89.30	37	83.62	CHANGED	hsKs-Llppl.........u.....pcs......s.l..o+ppspphlsshhctlppsL..ppucc...l....plsG.FGsFplpp...+tuR.pGRNPpT.G-.tlpl...ss+pslpF+suKpL+ctls	....................................................................MsKs-Llc..t.l.........A.........pps.......s..l.....oKp......cup....p.s.l-shhcs......lppuL....ppG-p........V................pL.h...G.FGoFpl..+c..............RssR...p....G..R......N...P....p...T.Gc..plpI....sAp..pVs..tF+sGKtLK-tV...............................................	1	797	1619	2112
+1313	PF00308	Bac_DnaA	bac_dnaA; 	Bacterial dnaA  protein	Finn RD	anon	Prosite	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.18	0.70	-4.70	14	6279	2012-10-05 12:31:08	2003-04-07 12:59:11	13	14	4628	18	1289	7863	4434	203.50	39	51.24	CHANGED	Lsp+YoF-sFVhGsSNchAaAAAhplAcs.Puc.tYNPLFIYGssGLGKTHLL+AIGNhshp.hP.shRVhYlsuEcFsp-hlculpc..schppFKcpYR.slDlLLIDDIQFlutKEpoQEEFFHTFNsLh-ssKQlVloSDRsPccLssh--RL+SRFphGLssslpPP-hETRlAILcKKhc....tcshs.....lPpElhpaIApplssNlRELEGAlpRlhsaushs	................................................................................p.paTF-.s.F..V.........G..p.......u.N.......p...h......A.....h..A..........A..u....h....t.....V....u................c............s......s.......u..t.....s........Y.......N...P......L......F..l.Y.G.u.s.GLGKTH.L...........hp....Al.G.......st.l........h..................p....t.t...........s.....s......s......+.V....h......Y......l....s..u....E.....p...F...s...p.......-...h.....l.p.....u...l....pp...........pt...h...p...p.....F.....+.......c....t.....Y...R.....s.......l...D....lL......L.I...D........D.........I........Q....F........l..........u.....s.......K.........-..........p..........o........Q.........E........E........F.F....a......T..F.N.....s......L......h.........c.....s......s........+.....Q......I..........l......l........o....S.......D......R..s.........P........+.................c...l.........s....s......l....-.....-.....R.......L....p..S.....R.F...s...W..G.L...s..s.sl...pP.P...-.h.Eo.....Rl...A....I.L.p...pKAc.......................t.p.slp...............lP.s.-V...h.pa.l...Ap.p..l....c...s...N.l...R-LEGALs+lhA.up..s................................................................................................	0	415	826	1072
+1314	PF01311	Bac_export_1		Bacterial export proteins, family 1	Finn RD, Bateman A	anon	Pfam-B_1442 (release 3.0)	Family	This family includes the following members;     FliR, MopE, SsaT, YopT, Hrp, HrcT and SpaR All of these members export proteins, that do not possess signal  peptides, through the membrane.  Although the proteins that these exporters move may be different, the exporters are thought to  function in similar ways [1].	27.80	27.80	27.90	28.60	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.37	0.70	-5.10	16	3358	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	2177	0	654	2099	515	239.20	26	92.63	CHANGED	pshhshlsthhLs.hhRlhshhhhlPhhspphlsuhlR..hulshhluhhlhssl.hsssshhsst...hhhLllpElllGlhlGhhhshsFhshpsAGplIDsQtGhsh.ushhsPssuspso.luphLshhulllalsssGhhhlls.slhcSaphhPlsphhs..t..thhthlhpthsplatpulhlAuPllhhLLLh-lulGlluRhAPQlslhsluhPlKshlullhlhlhhsslhshhppthphhhshhs	..........................................th.lhshhhs.hhRl......huhhhhhPhh.u.pps.l.P.s.t.l+....hsluhh.lsh..h.l.h.P....t.l........s..s..t....s..h....s..h...h.........s..........hh........hhhlshpElllGlhlGhhhphsFhsh.phAGplIshQhGhuh..uohh.DPs..s.u.s..s..s.s..lluplh...shhu.hllFl.s...hsG.........Hh.hllp.hLhcSaphlPlu.s.....h....h..h....s..s.............h........h.....hlhphh..shhahhulhlAhPllshhLlsslulGllsRhAPQLNlFsluhPlphhlGl..h.l...l...hh...h.h..shlhshhtphht.......t....................	0	202	393	515
+1315	PF01312	Bac_export_2		FlhB HrpN YscU SpaS Family	Finn RD, Bateman A	anon	Pfam-B_1200 (release 3.0)	Family	This family includes the following members:   FlhB, HrpN, YscU, SpaS, HrcU SsaU and YopU. All of these proteins export peptides using the type III secretion system.  The peptides exported are quite diverse.	22.10	22.10	22.20	22.80	21.30	22.00	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.85	0.70	-5.55	16	4381	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	2177	42	948	3009	756	267.10	32	91.14	CHANGED	.u.-KTEcPTsKKLcDARcKGQlsKSpDlsshshllushthlhhhushhhpcLtuhlth.hhhtspsashuhp.thhthhhhlhhshshhl...hhsshlsulhushlQsG.hlhoscul+Pchp+lNP..lpu...hK+.hFSsculhEllKSlLKllhluhlhahhlhsphsplhpLshss.tshhshshpLhhplhlhshhhhllluhhDahaQ+hpahKcl+MoKpElKcEaKcpEGDPclKu+RRphtpElt.ppphtssl.....cAsllVsNPTHaAVAltYc.pchssPhllsKGsDttALpl+phAcctslPllcshsLARuLYppschsphIPtphacsVAclLthlh	...........................................t...pKTEtsT.++hpcu+c.cGpls+Sp-...ls.hh.hhs.hhhh.h.h....h.h...h.............h....h.............t....h.....t...h....h.t...............h.........................................h......................................h..h.................h...h.............h...........h...h.h.h....h.h.h..h.h.hhs.hh.s.shh...s.G..hhh.sscs.l..php+l.sP..hts.........hKp..hF.uh.pshh-hhKslh+hhhlhhhhhhhh...h..thht.h..........s............t....h..h.hth.hh.hhhhhhhhhhhhshhDh.hpha.ahcph+Mo+p-l+cEhKptEGsPplKu+hRphtpth...........t...t....p...h.h.ttl.......pushllsNPT.Hh..AV.ALpYc....p....p.....s...A...PhVlAKGts.lAhpI+plAcc..pslPllcs.sLARu.Lapps.c.ls.ptIP..t..p..L..a..pAVAclLsal...........................................	0	309	593	767
+1316	PF05088	Bac_GDH		Bacterial NAD-glutamate dehydrogenase	Moxon SJ	anon	Pfam-B_6291 (release 7.7)	Family	This family consists of several bacterial proteins which are closely related to NAD-glutamate dehydrogenase found in Streptomyces clavuligerus. Glutamate dehydrogenases (GDHs) are a broadly distributed group of enzymes that catalyse the reversible oxidative deamination of glutamate to  ketoglutarate and ammonia [1].	23.00	23.00	23.40	23.00	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	1528	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.37	0.69	-14.31	0.69	-7.18	107	1221	2012-10-10 17:06:42	2003-04-07 12:59:11	7	6	1073	0	449	1248	467	1239.90	36	88.15	CHANGED	l+lhs....htp.tshpus.pollplls-DMPFLVDSlphtlscpulsl+hlhH.PllplcRs.tsGplhpltstst........................ssttEShlhlEl-.+hs...sspphpt..LpppLppVLsDV+tsVpDWpsMpschpph.hpplp...pp...................chpEstsFLcWLtscpFoFLGa+cYpl....................tss.thtlt......ssouLGlL+..........t.httspphsshssttttthhp.sph.LlloK.ustpSpVHRsuYhDYlGlKc.a...cppG...pVlGEpRFlGLaTSsAYspssppIPllRcKlppllppuGasssoHsuKsLhplL-saPRDELFQhst-pLhchuhullp.Lp-Rt+lRLFlRpD.asRFlSsLValPR-+YsTplRh+lpplLtcshsu.pts-asshh.sES.sLARl+all+h........sssph.......h-hpclEppltchsRsWpDclpssLhpp...........hup..............................tputtlhp+YssuFPtuY+-passppAltDlpplcpL.........ss..ssslshplY......+s..pss....sp..l+LKlap.tspslsLScllPlLENhGl+VlsEp..Papl....ph..t.....st.....pshWlaDFsLp..hssst.......hclsp.............hpptF...p-AastlWpGcsEsDuFN+LVLtAuLsWRplslLRAYu+YL+QsGhsaSQsYltpsLsppPsluptLlpLFcsRF..-P.........................................ttppcspptptlpsplppsL-pVssLD-DRILRpahslIpATLRTNaaQt.......st........pGps...+salSFKlcsptlsslPtP+PhhEIFVYSPRVEGVHLRsGpVARGGLRWSDRpEDFRTEVLGLVKAQtVKNAVIVPVGAKGGFlsKphPss.s.....sR-uhhsEGhtCY+hFIpuLLDlTDN..l.lsGc.........lVPPs..sVVR+DsDDPYLVVAADKGTATFSDlANulut-.YsFWLGDAFASGGSsGYDHKtMGITARGAWESVKRHFRE.hGlDsQo.psFTVVGlGDMSGDVFGNGMLLSccI+LlAAFsHpHIFlDPsP.DsApSasERcRLFsLPRSSWsDYDpsLISpGGGVFsRouKoIsLSsch+thLGl..cps......phoPsELIpAIL+APVDLLWNGGIGTYVKAosEocu-VGD+ANDulRVsGp-LRsKVlGEGGNLGhTQhGRIEaAhpG.....G...........RlNTDhIDNSAGVDCSD+EVNIKILLsplVpsGcL.ThcpRNpLLtpMTD-VupLVLcs.NYtQopAl..SlsptpuspplstptRhhptLEppGpLcRtlEhLPs-cplscRtstGp.GLTRPELAVLlAYuKhsLp-pLlsS.-ls--s......ahsphLhsYFPp.Lpc+assp.ltpH.LRREIIATtlsNplVNchGh.....sFlhRlt-pTGsss.sclscAashucclFslsslWppI-uLD.splsuslQhphhhplp+hlc+sspWhLRs...ppt....h.s.lsstlspapsslppLp....splsshLsspp..tpthppptpphsp.tGlPpsLApplAslphhhssl......DllclAppssts........l..tplApsYFtluppLslshlhptlsp.lsssspWpsLARt.....uhp--LtttpRpLstslLpt............t......spttlstW..hppppstlpRhpphls-lps...sssh-hAhloVAhRpLpsL	....................................................................................................................................................................................................................................................t..hshlpll..shPaLlDSlhh.ltp..shthph.hhp.s..htltRt...pu....tl.tl...................................t...pohhhlpl.........s...t...........sttthtt...lpptl.phLtplt.sspDh..hhtth.th...httlt....tt................t.....................pht-shthLpWlt.sppFhhhGhpchth.......................t....t..h...........tstLGlhp.................................................th.......h..p.......l.hlsK.ss..Shl+R..ssY.Dalul+.....hstpG............t.hhuEpRhhGLasussattss.pIPhl+p+httlhthu...uht...tuash+tLhpllpphPR--Lhphs.ppLhthshsllt.htp.+.ph+lhlRh......D.hs.+FhssllalP+-casoth+.thtthlhp.htu.t.h.-..hshh..s-.uslsphphhlch......t.tt...............t..hs.....ttlptplhphspsWpDph.thh.tt...................................................s......tphttsFs.sY+pthsstpAlhDlthlttL................................st.....p...lth.hh.p....ts..t..............tt.........hphKl....ap.tttsh.LSplhPhLpshGlcVl.sEp..sapl.h.................ps.........t.h.alh-Ftht....t...............hp.h..t.p......................ht.tthppAhtth.atG.p.h.EsDsFN.pL..lhtAuLsh+pl.slLRuhu+Y....l.....+Q.h.....u.h.....s.....aSpsYl..tp.sLp..p..aPp..l..sctL.lpLFpt+F.....sP................................................ttptpppptp..t.l....t..p.p...ltpt.L..-...p.V......s......s......L.D....-.....D.R....I..L.Rpah...sll.pA.oLRTNaaps....................t.................t....s....+shluFKhcP........ph.....l........s........p.l.....P......t.......P....p.......P.haE.....I.F.V.Y.u.PclEGVHLRhGtVARGGLR..........W.......S......D......R.p...ED.........F.......R........T..........El.......L.GL.......V....KAQtVKNsVIVPlGAKGGFls+p..P.s..s...........................sR-thht.cGh.tsY+h...F..I.puLLDl..TDN......l..h....p....up..............l..VsP.t..p..V.VRa..D.tDDsYLVVAAD.KG.T..A..T.FSDhA..Nslut.p..as..F.WLGDAFASG...G.S...s...GY....DHKtMGITA+GAWEuVpRHF+E.hG.....h......DhQ.s.psFTslGlGDMuGDVFGNGMLLScpI+LlAAFsHhHIFlDPsP.DsttSatERpRLFpL.PR.SSWtDYstpLIStGGGlasRstKsIslosphpthLslpts..........................phsPs-LlpAlLpu.VDLLWNGGIGTYlKuspEocspVGD+ANDslRl.sup-lRs+l..lGEGGNLGhTQhGRlEauhpG.....G...........+lNTDhlDNuuGVDsSDpEVNIKIhLs..th..l.t...........sGcl...s.p....pR...spLL.pMoD-VuplVLts.NhtQs.s..l..uhstt..puhthht..tchhp.LEpp.s.h.L.sRtlEhLPssppltcR....t......t..G..sLTpPELulLhuasKhsLtctllt.o.pls-...-s......hh.sp.L.tYFPt.....lp.pp...aspt.h.pH.L++EIlsT.lsNphlsphGh.....sah.Rlt-psGts..splhpsahhscplatlstlhpplp.t..L..s......lss.................thp.phhhthtchhpcsspWhLpp.....t.t.........s.ltt.ltpat.thttlt.....phsthl.....t.tp..htthptthtthhp..tGl.sttlAthluth..hhs.hh....sI.hpl......u.p.......ts..hs.........................h.ttsAchYatlupthththh.....hpthpt...s.hsshWpshAttshp--l....ptlshtsLt....................p.............tt.ht.W....t.t.pt..ltph.thltphtt.....tt.......h...phshhsls.t.h..........................................................................................................................................................................................	0	153	284	373
+1317	PF01152	Bac_globin	Globin;	Bacterial-like globin	Finn RD, Bateman A	anon	Prosite	Family	This family of heme binding proteins are found mainly in bacteria. However they can also be found in some protozoa and plants as well.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.47	0.71	-4.10	12	2140	2012-10-01 21:46:00	2003-04-07 12:59:11	16	28	1468	69	809	1739	270	116.80	24	78.59	CHANGED	ola-tlGGpss.lcslsscFYspl.sDsp..htphhp.sschsspcp+.htFLsthLGGPshYht+pG+P.L+tpHtsh..slsstch-thlcphtpAlpshs.tshs.-phhchhphhttshhsh	...................a-hlGG....pps....lpplV-pFYs.t.l.tpDsp.................lt.h...F..t......s......s......-...h...s..........p....t...pp+...h...t...p...........Fl...st...h...h.....G..G..P.......s..h.Y....s.t..p..p...........G...p........P...........l....+....t....p.H..h...sh........sIst.tc.h-tWLpp...hpp.A.l.s.c.h...s.h..s..t.t...h...tp.....l...h.thht.htt.h...t........................................................	0	348	595	732
+1318	PF00296	Bac_luciferase	bac_luciferase; 	Luciferase-like monooxygenase	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.70	0.70	-5.30	155	15488	2009-09-11 11:56:34	2003-04-07 12:59:11	15	68	3031	48	4888	13559	5534	299.40	18	82.83	CHANGED	h..........hhh...phth.h.st.................shpphhchAptA..Eph.GF-shhhs-phts........................h-shshhuslA.stTp+lclssultssh..p....pPshlAppsATl-.plSs......GRh.tLGlGs.Gttthp...hthh.....Gh.........shscphsthcEhlcll+tlh....tt......................pps.sacGca..hph...........................tpshhhPps......................P..lhluutu.spshchAuchuDshhshs..............ts.sthtphhsplcp.tstp...........tGRs.....shphsh.thhlhhs....cspppAtpth......hthh.........................................................t..thtthhthh..tthhtshsh...lG.osp.pl...tcpltp..htpsGssp	...................................................................................................................................................shpthhplApt..A..E.......c.........h..G.a.cthal.s..-pht.h.........................................ss...hsh..lut.lA.s..t..T..p.......+..l....c..l......u.s..ush..hhs...p........sP.h.hlAcp.hu.oL.D.plos...........G......R.h..tl.s..l.....u....s....G.........t..t..t....p.........hpt.h........Gh.........................sh.s.p.p.h.p...t.h...p..E...h....l..p...llp.p..lh.....ps............................................t.h...sa....p...Gca....hph.......................................tssth.h.P.t.shpt...............................hP...lah.u.u........s..u..s.............t..u....h..p.h..AA.c..h....u.p.shhhss....................s.p.t..h.t.p.h...h.p.t......h.+p....th..t.t...............................tG+..t.........phph...h.....h...th....h......s...hs.s...............c..s...p..p..p..A.hthh.............tthh............................................................................................................................................h.......t.....h.........................................h..t.t.hhh..................lG..ssp..pl...tptltt....h.t.....t...................................................................................................................................................................................................	0	1231	3130	4170
+1319	PF01036	Bac_rhodopsin		Bacteriorhodopsin-like protein	Finn RD, Bateman A	anon	Pfam-B_1412 (release 3.0)	Domain	The bacterial opsins are retinal-binding proteins that provide light- dependent ion transport and sensory functions to a family of halophilic bacteria [2,3]. They are integral membrane proteins believed to contain seven transmembrane (TM) domains, the last of which contains the attachment point for retinal (a conserved lysine). This family also includes distantly related proteins that do not contain the retinal binding lysine and so cannot function as opsins.  Some fungal examples are: Swiss:O74870, Swiss:P25619, Swiss:P38079, Swiss:Q12117.	21.90	21.90	21.90	21.90	21.30	21.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.64	0.70	-5.04	17	3174	2012-10-03 04:04:29	2003-04-07 12:59:11	13	10	618	161	242	3093	2566	141.90	35	89.93	CHANGED	hshaslhulhhllushlFhhhshp.sss.p+phhssslhlsultuhuYhshA.slGhohsts..................cpla..hs+YlsWhlohPl.....lLhLs.lAsss...................tpslhshlhsshlhllshLlGulh..sush.....+asaashussshLhlhYhlh.sshtpsstshspp...shahhLp.hhlll...WhhYPlsWhlustGssl.sssspslhashLDllshlsashlLlhttsshsstt	.......................................................................................................................................................................................................................................................................RYlDW....LlTV.PL.........h.hh....l....l...Ls...t...l....s...s.ss.................................................sul...h.a.+....L..l.h.uS.ll.MLls.G.Yh.G...E.......s........shh.s..............sh.h.h.a..l.l.u.h.h.u...alYI..l.Y.p...l...........a..G.....Es.u....c.s..u.s...p..u..u.ss.s....tsAasshph...lVhlG......W.u.lYP.................................................................................................................................................................	0	69	151	216
+1320	PF01103	Bac_surface_Ag	Bac_suface_Ag; 	Surface antigen	Finn RD, Bateman A	anon	Pfam-B_1201 (release 3.0)	Family	This entry includes the following surface antigens;    D15 antigen from H.influenzae,    OMA87 from P.multocida,    OMP85 from N.meningitidis and N.gonorrhoeae. The family also includes a number of eukaryotic proteins that are members of the UPF0140 family. There also appears to be a relationship to Pfam:PF03865 (personal obs: C Yeats). In eukaryotes, it appears that these proteins are not surface antigens; S. cerevisiae YNL026W (SAM50, Swiss:P53969) is an essential component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The protein was localised to the mitochondria [3].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.90	0.70	-4.97	70	6186	2012-10-03 17:14:36	2003-04-07 12:59:11	18	36	2849	0	1843	5261	3202	320.30	19	47.88	CHANGED	NhhGpGpplshshs..............hu.............p.hppshshsaspP...ahhsp...............thshuhslhhp......................................t.st.pshshpshuhslshuh.....ls.......pphphs.....huhshppsphpstssps................................................................tttpstththshuhshsshssth.hPopGhh............hphshchs.....................h..huussp..ah+hpsps.phahsltp..pt.hhh.......hs+hphGhht.ths..................stc.lPhhcpFasGG..........ssSlRGaphsslGPps...............................ptt.lGGpthhsuShEhphPl.h.....t..t.hpsuhFhDsGs..............sassptpss.......................................psusGlGlpWtoP.hGPl+hDaAh.Pl....pc.ss.sp.................pp.papFulG.ppF	...........................................................................................................................................................................................................................h.utGp.phshs.hp.........................hs.................t...ppth.phsh.p.P............hh.h.s.p......................................t.h..ph.s...h.shhhp..................................................................................................p.....sh..s...t..p......s...h.u..h..s..h.shsh....................hs.................................p..t..h.p...hp.......................................hs.h..s..h...p..p....s..p..h.p..p.h..p.ps..............................................................................................................ps.h.h..h..s..h..s..h..s..hs..h......s....p...t...c......s........s....h...h.....P....s...p...G.h.............................................................hph.s.hchs........................................................................h....h.u...u-.sp.......ah+.h..ph..ps...p.h.ah.slsp...........tpthsh.............................................hh+s..phG..h...ht..shs................................................st.p....l.P....h....p.p.....F.a.s..........GG...................s.p..o....l..R.G..........a.p...p.s.l.uPpt..............................................................................ttt..h...G.G.s..t..hh.su..ohE.....hp..h.....s..l...................tt..p....hp.....s.uh.F...h....D......sGs.....................................l.h.s.....s..t.t..p......s........................................................................................................th+h.usGl.G...l..pa.......h.......o......P....h....G......P.....l.p.....hs..hAh..sl......pp...pt..t..............................................tt..th.hslG.t...............................................................................................................	1	578	1140	1548
+1321	PF01338	Bac_thur_toxin		Bacillus thuringiensis toxin	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	26.00	26.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.51	0.70	-5.12	7	74	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	26	16	17	68	0	187.60	43	89.80	CHANGED	pps..ppshRhIhLpV.ss.-.ssh.pIh.lp.Ppal.QAltLAsuFQsALsP........sLpFshpKuLplAssl.Ppuul.VshlsQolpQosspVSVMls+VlElLpsVLGlsLsuosh.pplpsuITsTFTNLssQps-AWIFWt+poAppTsYpYNIlFuIQNtpTGuhMhslPluFEIsVslpKcpVLFhTI+DpAsYpVplpuLplsQsL.pppthslhsl.pshs.sh	...............................................................h....................ph.pl..lp.spYl.QAlhlsssFQsAlsP.........sLpFsh.KuLpIANsl.PtuuV.luhlsQsVhppsspVSVMIsplhE.ll+..oVL.......Glslsu.ush..splsuAITNTFTNLssQpsEsWIaW..tpp..o.A..sQ.TsY.pYslLFuIQ.NppTGthMhhlPluh-ls.V.sht+pplLh.hsh.psptpatVphpth..........................................................	0	1	6	12
+1322	PF01654	Bac_Ubq_Cox		Bacterial Cytochrome Ubiquinol Oxidase	Birney E, Bateman A	anon	Pfam-B_1148 (release 4.1)	Family	This family are the alternative oxidases found in many bacteria which oxidise ubiquinol and reduce oxygen as part of the electron transport chain. This family is the subunit I of the oxidase E. coli has two copies of the oxidase, bo and bd', both of which are represented here In some nitrogen fixing bacteria, e.g. Klebsiella pneumoniae this oxidase is responsible for removing oxygen in microaerobic conditions, making the oxidase required for nitrogen fixation. This subunit binds a single b-haem, through ligands at His186 and Met393 (using SW:P11026 numbering). In addition His19 is a ligand for the haem b found in subunit II	26.20	26.20	26.50	26.80	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.47	0.70	-6.07	178	4711	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	3032	0	940	3110	321	447.50	39	93.87	CHANGED	LuRhQFAhTssaHhlFsslTlGLuhhlslhE..shaltTs.........cph....Yhchs+FWsKlFulsFAlGVVTGlshpFQFGsNWutaSchlGslhGssLAhEsLhAFFLEusFlGlhlFGWs..Rl.upthHhhushlVAlGoslSAhWILsANSWMQ.sPsGa..ph...............ps..G+hph...ssahsl.............................lhNPsh.h+asHslhAualouuhhVhGluAaaLL+.............................tc.....ch.....p.hh+....+uhphuhhhullsuhhtlh.sGDhpGhpshcpQPhKlAAhEuhW.-...T............ps......s..A....shslhulPsp...csp...c.......spat.lpIPhhhSlls...................s..+shsu.pVt.GLp-....................................................hst.........................................................................p.hP.s.VshlFauFRlMVGlGhhh.lhluhhuh.....ahth.+..................................p+ahLthhlhshPh.salAspuG.WhssEhGRQPWsVaG................l.........LpTspul.Ss...lsssplhhSLhsFhllYs.hLhs.stlhlhh+hh+....pGPps	.....................LuRhQFAhTshaHalF.lPlTlGLuhhlAlhEslal....hTs................cph.........Y+....c....hs....+....FWu.K.lF.u.I.NFAl.GVsTGlsMEFQFG..T..NWShYSca....VGDIFGs...P.LAhEuLhAFFL.EuTF.lGl.ahFG.....Ws..R...l.....s+hh.HhhsTahVAlG..oslSAhWILsA.NuWMQ.sP..sGh...ch..............................................c..s...h..R..h..c..h....ss.ahtl.........................................................................................................lh.NPsh.s+Fs.H.slsuualouAhFlhuluAa..aLL+........................................................s+.........c.h........s...ht++.uht.l.uhhhuhhuslss.hl.hGD.tpGhphtch.QPhKlAAhEuhWc.T.....ps............s..A...shslh......u.h......Psp.......cpp......c....................spau..l.pIP..h.hL.ullu.....s..+.o..h..ss....V...GLc-........................hst.......................................................................................................................c.thP.s..VsslFauFRlMVuh.Ghlh..lhlh....hh.uh..h.hhh...+...pcl...p......................................p+WhL+hslhshP.h.salAlpuGWh.ssEh..GRQPWslhs..................lL.TtsAs..Ss....los.upl.hh..Shlhas...slYs.llhhs.t.la.lhh+hh+tGPt.s........................................................................................	0	271	564	761
+1323	PF00936	BMC	Bact_microcomp; Bac_microcomp; 	BMC domain	Finn RD, Bateman A	anon	Pfam-B_1071 (release 3.0)	Domain	Bacterial microcompartments are primitive organelles composed entirely of protein subunits. The prototypical bacterial microcompartment is the carboxysome, a protein shell for sequestering carbon fixation reactions. These proteins for hexameric structure [1].	20.60	20.60	20.60	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.50	0.72	-4.30	128	7283	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	957	198	954	3181	404	77.20	31	65.78	CHANGED	pAlGllEs.puhssulhAADthlKuAsVcllthctss..u.G..........hhhl.hlsG.DVuuVpsAlcuuhpsspc.h.........llsphl....l....s..ps	.............pAlGllps.puh.ssul.AADshlKuAsVpl.ls.hcphs.....u..G..........hshl.hlpG.DluAV+uAlcAusssspc.................lhs.hh.h.............................	0	418	700	840
+1324	PF02397	Bac_transf	Bact_transf; 	Bacterial sugar transferase	Mian N, Bateman A	anon	Pfam-B_1538 (release 5.4)	Family	This Pfam family represents a conserved region from a number of  different bacterial sugar transferases, involved in diverse  biosynthesis pathways.	20.40	20.40	21.10	20.40	19.50	20.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.31	0.71	-5.18	461	7019	2009-01-15 18:05:59	2003-04-07 12:59:11	11	45	3624	0	1678	5749	1907	186.40	39	54.00	CHANGED	KRhhDllhuhls.LllhuPlhl.l.lAlhl+l..ss...GP.lhFpQpRhGhsG+.....FphaKFRoM.hs...ss..-pt.............hptth........................c.sDs......R.lTp.lG+FLR+TS..LDELPQLaNVL.+G-MSlVGPRP.h.....tpsc...ph..h.s.....thttR.hpV.+PGlTGhAQVs....tpssh.shpp...............+lchDlhYlcshS.....lhhDlpIlhpTlhsll...h.c..GAh	...................................KRhhDllhu.h.lh..L.l.l.h.u.P.lh.l.l.l.u.lhl+l........s.t.......G.PlhFp.Qp.RhGh......s.G+...............Fp.laKF...RSMts..ss.....-pt........htp.hh..........................................................................p..s.Ds..R..lT.+........lGcFlR+TSLDELPQl.hNV.L.+G-MSlVG.PRP.h.s.........pt...h...c.....p...a.....p..................................phht.R.hpV+PGlTG...hAQls...........spssl..s.hp.c..............................+lc.hDlhY....l...c...p.h.S......lhhDlcIl.hpTlhhlh..t..p...t...........................................................	1	576	1136	1441
+1325	PF01721	Bacteriocin_II		Class II bacteriocin	Bashton M, Bateman A	anon	Pfam-B_1954 (release 4.1)	Family	The bacteriocins are small peptides that inhibit the growth of various bacteria. Bacteriocins of lactic acid  bacteria may inhibit their target cells by permeabilising the cell  membrane [1].	21.10	21.10	22.20	25.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.91	0.72	-4.43	19	138	2009-09-13 12:44:13	2003-04-07 12:59:11	13	3	75	11	5	112	0	35.30	47	58.83	CHANGED	KYYGNGVaCsKcpChVsWGpAhssIsstsssuassG	.+YYGNGVYC.s.Kpp..ChVsWucAhssIushshsuahsG...............	0	2	4	4
+1326	PF04798	Baculo_19		Baculovirus 19 kDa protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6291 (release 7.5)	Family	Family of Baculovirus proteins of approximate mass 19 kDa. 	25.00	25.00	28.20	34.00	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.93	0.71	-4.81	23	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	60	0	0	60	0	142.40	44	76.49	CHANGED	hhNPapphsp+LlcsatsoLpaGsaIcVaDhp....cs-RLFlIcPENlllYNssGsLYYYLE..uSuhhCP.sEFulVRFopsDIpsINEoGhashsCTslsSLsLlEHFho..ssls-tplhLs...p.phpaoIlDlINhLIpsGYlplp	...............h.hNPappphppLlcDatsTLpaGs.YIclYDLSsss.csERLFlIcPENVlLYNhsGsLaYYLE..SusVhCP.sEFulVRFops-IpslN-oGlasssCTsVsSLsllEHFhoLKNslsDppllLsh.....c..pIpaoIlDlINaLIhpGYVpl......	0	0	0	0
+1327	PF04631	Baculo_44		Baculovirus hypothetical protein	Mifsud W	anon	Pfam-B_5343 (release 7.5)	Family	This family includes several hypothetical baculoviral proteins, with predicted molecular weights of approximately 44 kD.	25.00	25.00	29.90	29.20	17.30	17.20	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.35	0.70	-5.84	23	108	2009-09-10 23:58:53	2003-04-07 12:59:11	7	1	82	0	0	99	0	265.80	44	92.09	CHANGED	LlllllllFLallY.pPlapAatpI+psQtpYspplD-ph-hhppsLpRRRYVPLcsLPslcasoshsTlst.Gph+ChSVPlhVosscTssFDCoplCDNssAsYFFVspaD+FVVNGphLspGGYCTTNSlPRNCNRETSllLaSlNQWTCIAEDPRYFAGpsNMlQlAGRQHuscIhPuplc+NVLaD+LLstpVslopNTFRpsWDElhpDGo.RRFEl+Cs.ALD.+pNpMFVNPlNPIECLPNVCTNVpaVHpsVRPsFEsG.C-CGDhslTRVpHlsssD+TShCASIVDphcpsstSa.......pFRV-ClshDoPlocasts..+LLCPsclFspNTDsAYsFsLsGs.hPlSuNGIcEPTaRhahDTRsR.lsass	......................................................................................................h..LPslphssp.hsphst.....st.cshp........sshhl.u..p....h....s..shD..CstlCssssu..hhF...alsp.sp..hVlNsphLt.GGaChssSlsR.CN.hpTS.hhlholspapCluEDPRYaAGstNh.QlAGRQH.spIhsup.s+NlLaDpLLstpVssspNTFRp.pWDEhh.DGo.RRFEh+Cs.AhD.ppN.MFlNPhNslECLPNVCT.s.VphlH.sV+P..sF..-...s...G......C-CG..t.hch.p......tohCssh....hp.................h.....Chth...h..h...............................................................................................................................	0	0	0	0
+1328	PF04786	Baculo_DNA_bind		ssDNA binding protein 	Waterfield DI, Finn RD	anon	Pfam-B_6251 (release 7.5)	Family	Family of Baculovirus ssDNA binding proteins.	25.00	25.00	44.80	43.80	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.59	0.70	-5.23	21	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	55	0	0	62	0	244.20	27	81.91	CHANGED	Wh-phlaNL..pp.tNhollpCsssh..NpLtcsLshlppphsl..pahcchhP....pht..cplslhcPp..ss+lsYplGhpV+GGhhs.FYaFDhspl+Rscu.saGcFlolpWsshhhHNplauplhtpah....thp.-.thpLpssshlslPpc.........p.sp+pshlRKFFslppcpNpplYsTGc.....L..hctlpscPaoh-cFcplFphp.scs....sScEVpMlhuulI-GhKpuKp-hphco.lss+clpEKsYSLAl+PhlFhplE	............................W.cphhhNL...pp...tN..hollp.Csss...ppLpcpls.lpphhsl..phhcc.hhP........p.s...pplslhcsp..ss+ssYplGh+lcGssps.FaaaDhsplK+scu.sa..G.cFhslpasshttaNplauplhtpah.....t.ppc.slplpsslhlslPcc...........sp+phFlR+FaslpppsNtplasTGc.....l..scs..lpspshol-cFcclFphptspp....sSpEVcMlhsuhI-GlKpuKt.-hphps....lss+chp..EKsYSLulKPhlFhhlE..............	0	0	0	0
+1329	PF04639	Baculo_E56		Baculoviral E56 protein, specific to ODV envelope	Mifsud W	anon	Pfam-B_5446 (release 7.5)	Family	This family represents the E56 protein, which is localises to the occlusion derived virus (ODV) envelope, but not to the budded virus (BV) envelope [1].	20.60	20.60	20.70	28.60	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.66	0.70	-5.76	25	71	2009-09-10 14:49:23	2003-04-07 12:59:11	7	1	62	0	0	66	0	286.80	48	84.53	CHANGED	ssPoohsl.ussphhPGYslsNspFVSsu-...lNplhRNNDlsulRplFss.sossQlNGLspLRRuDNlPDAslHuhphR+suVKssaPc.TssRT.pGVpsuLspNPRLssYL...KsAGhssLlGsGVYLlhsuAsLV.pDIlcALNRTGGSaYhpGpNGG-...sl-uClLpaRoCshshssl...ssslC........shDPLLss..spLpslCpGYNaEsEpoVCRuSDPNA-PsS.QYlDIS-LsssQTIpClEPYDhGDLIGDLGLDaLLGEsGllspSSNuSp....SlSssLhPlIllIGullhllhIGahIaKhlhppps	........................................sPoohsl.uNsphhPGYslsNNpFlSsu-...lNplhRNNDlsslRplFss.ssssQlsuLspLRRsDNlPDAslHutphR+suVKpsaPp.TssRo.pGVpssLppNPRLssYL.shKsAGhssLlGsGlYLlhsuAoLV.tDIlpAlNRTGGSYYhpGpNGG-...sh-sClLhhRTCths..ss...tslslC........shDPLlss..spLpslCpGaNa-sEpo...VCRuSDPsADPsS.QYVDIS-LsssQTI.ClEPYshGDLIGDLGLDtLLG-.cGLlspSSNsSp....SlSspLhPlIllIGullhllhIha..hlaKhlhp..s....	0	0	0	0
+1330	PF04850	Baculo_E66		Baculovirus E66 occlusion-derived virus envelope protein	Mifsud W	anon	Pfam-B_4624 (release 7.6)	Family	\N	25.00	25.00	113.00	112.00	19.10	17.80	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.41	0.70	-5.47	28	75	2012-10-02 15:11:41	2003-04-07 12:59:11	7	2	51	0	0	75	0	381.70	37	56.26	CHANGED	cssVNhpslppuIphVuSscGllNPAlhSRNGopaS.sVIGpFl-Ys.uVaSADaSKVLThhocpYaGSVVGsTsclAY.....YEADssNshaAPLWAMsRRIWscs...utllsY...p............spolshESGVlL.pshsGl............hslPo.....TssSTpSFpPslupT.AlspTcssG.AMlsau+FsELN.LEFcShTLYacpGMaQLY.pltshpsshss.....suRsVVLsRDh....s.pTs.-.sas.......suSs.stoaNGVss++hsIsNh...slsshslR.s.sslp..............hlEQlIuh-slpsGsGssCYpLsVps.....sDsspshplssssh...................hhhssssslcslFcFPal.hlK-spptplo.sstsst...........lshsslpplLshlshsstsl..hss..ptssssFhhpss..s.QFhFch	...ssVNhpNlppuIphVGSscGhlsPAlhSRNGopaS.sVlGpFl...-YssuVaSADaSKlLTlRocpYaGSVVGtosclAY.....YEAD.sNshHAPLWsMTR+IWsps...utllsY.p.................................sss..lshESGllL.pshNGl............hplPo......TssSTpSFpPsluhT.AlssTc.suG.shh.au+FsELN.LEFhSYTLYacpGMFQLYspI+slpshsss......uRCVVLsRDh.......s.sss.-.sap............ssSN.htsaNGVss+HaNIs.N.......slssFslR.shssls..............hlEQIIuhcslNsGsGsuCaoLhsps.....sDsspsh+lssssh..................hlhhsssssl.cslhsFPal.llK-spspplohssssst....st..H..lshspIpphLshlshsstsl..hss.hpc.psssFhhpss.tu.QFpFph...............................................................................................	0	0	0	0
+1331	PF03258	Baculo_FP		Baculovirus FP protein	Mifsud W	anon	Pfam-B_4275 (release 6.5)	Family	The FP protein is missing in baculovirus (Few Polyhedra) mutants [2].	25.00	25.00	26.10	26.10	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.20	0.70	-5.22	12	67	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	56	0	1	62	0	186.50	49	94.67	CHANGED	M-...ppLINVslLKsLIKsEIDcsVo-NIphlssKLK+LEc-pLNDoVEIYGIHDsR.LhsKKIRs.YlKKICuLLsL-aKtVl-SsacKNHIhV+LsDAsTA+EWQo+SREhRLKNaDLsI-aDGPVKIFVAAosEHK.LLKKTRDALLPaYKYVSLCKpGVMVR+s-+S+laIVKNEpDI.pLlsp.hpuhcsts......ts.t..t......pplI	..............................ppLINVslLKsLIKspIDcsVssslphhstKLK+LEpcpLscoVEIYGl+Dp.R.L.hsK.KlR.s.YlKKI.CsLLsLsaKtVl-osa...cKNHIhlKLsDAssA+EWQs+SREhRLKNaDL...........s..I..-a.D..GPVKIFVAA..osEaK.LLKKTRD.ALLPhYKYlSlCKpGVMVR+s-+S+laIlKNEpDIp.Lhsp...th........................h.................	0	1	1	1
+1332	PF04700	Baculo_gp41		Structural glycoprotein p40/gp41 conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4278 (release 7.5)	Family	Family of viral structural glycoproteins [1].	23.10	23.10	23.90	188.30	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.25	0.71	-4.86	21	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	57	0	0	60	0	190.70	50	57.94	CHANGED	sKRF-SD-pLIcaYtpLpKchsssshsp......sIFpsSFVhS.lh.uYApKFYs+........plsEAAcpLS.ulpYQlApAVTpNpPlPLshspplsN-YlpLLhp+AsIPsNlppuls.....sps.spLN....hhssllNsll-DlFsG.tssYYh.hsLNpcsRu+VhshK-NIuaLs...P.Lot..SssIFpaluphATpsG+	...sKRF-SD-sLIcaYtRLpKELGssslsc......sIFpsSFVhs.lLPuYAQKFYN+GuttlutsulsEAA+pLuhAlQYQlApAVTsNpPIPLPFspQLuNsYlTLLLp+AslPsNlQpulp.....SRphs+lN....hIN-LINsVIDDlFsG.uusYYh.YVLNEcNRARlloLKENluFLA...P.LSu..SsNIFpaIApLAT+uGK..	0	0	0	0
+1333	PF03273	Baculo_gp64		Baculovirus gp64 envelope glycoprotein family	Mifsud W	anon	Pfam-B_4223 (release 6.5)	Family	This family includes the gp64 glycoprotein from baculovirus as well as other viruses e.g. Swiss:P28970.	19.70	19.70	20.70	19.80	18.10	16.90	hmmbuild  --amino -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.87	0.70	-6.33	6	42	2009-09-11 04:57:11	2003-04-07 12:59:11	8	2	26	1	1	43	0	366.50	45	89.09	CHANGED	EHCNAQMKoGPY+IKsLsIsPPKEoLpKDlpIclsETDhsENVlIGYKGYYQAYAYNGGSLDsNTplpEsLhTlsVuK-DLLMWGlRQpCEVGE-LIDpWGSDSpsCaR-.sGRGhWV.....sGKELVKRpNNNHFAaHTCN+SWRCGVSTuKMYTRLpCss-oD-CpVpILDINGssINVotscVLH..RDGVSMILK.pKSchoRRopKlACL.........lKDDKsDPcoVTREH.........CLl-sDIFDLScNpWhCKFN+CIK....R+sEpVVKpRPpTWR+Dt.sKacEGs..oATKGDLMHlQEELhYENDhLRMNlELLHuHINpLNNhhHDLlsSlAKlDERLIGNLMsNSVSSTFLSDDTFLLMPCTsPPsHTSNCYNNSIY+EGRWVuNoDooQCIDFsNYcELAID..DDlEFWIPTIGNTSaH-SWKDASGWSFIAQQKSNLIoTME.TKFGG+sTSLpDlsshupGpLsupLtShhhGphhsalllhsVIlFLhCMlRstsR+	.....................................................................................Noth.t.h..hs.ttt-LLhWu.pppCphG-phh...DpWGSDS.sCht-..stt.Ws.tKELV+RpsN.+.FAaHhCNhoWRCGloTochas+Lpss.....sD-s..p..VhhL..sGssIslotspsLa..ccshShllK.ppophppcphKluCh.........htss.sDPc.lst.-.+..........Ch.sssha-lopspa.C+.stCh+.............cc.t..s.p.+P.pa+hs...c...h...sAohtDlhpl.ppLhYE..s-hL+hslp.hct+hsplsshhpsLl.SlAKlD-RLIGpLhspssuSpalsscpFhLhPChps.s..tsSNChssslYp-GRWsts.sDsspChshtt.p...lc.....hphhhs.ltsssh+tshpDtpGWSFlAppKpsLIpTMp.T+.GG.sTSLpslhths.G.h.tph.u........hhlhhhhhhhhhhhhp.....t...............	1	1	1	1
+1334	PF04735	Baculo_helicase		Baculovirus DNA helicase	Mifsud W	anon	Pfam-B_3393 (release 7.5)	Family	\N	25.00	25.00	116.10	48.10	18.20	17.80	hmmbuild  -o /dev/null HMM SEED	1173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.23	0.70	-14.16	0.70	-7.20	25	73	2009-09-11 13:37:16	2003-04-07 12:59:11	7	2	60	0	0	73	0	1095.40	37	98.75	CHANGED	tIhssIhpshp...pp-phsssshsss-pllh+Nssot..p++hlcsh-sFpKLlsshssptsts...........................t............ptt..h..........................tsHsWshpsNhF.shhV+PFlhtccY-p...lpcplshpcFhsopssthuNcCspuG-YhYWPN....hulsahGWplYLphpasIclsspIPLlHN+cLGsVNLFs.sschFLslEhsl.ssps..ppLFVNG+othscp.p........-cLFplshs....ssssusCKhsscLVaS.NKshFcYl+D-INLppChssscY+pllc.lDLpsLRhFsstt..sssslsst-ct..........pspppITPSSEptcpIpppIc-ClphIpEsMhcshspp-pucs..lLppYhppSsFhNFcYLIlslW+hlp+spch...pascTDI+LFlELLC...........Eplaus............ct..thcpshpcCcPYhphosplap+FCsphshFsssss.....h.uLutYaAIHahIYtKpss..........WsaThcsshp.Cslss-V.....lstGFFKKI..psspsshlFNGK.HYphVK..KDDDLhKlh-cssslslSslKFNNWKYhYhTEcGVaNVhppsY+ssCPFllGsTLhpsahc+s-..pYLscslhsaMhssscpEhsIaKhYHsAKlsR-l+hlKsNhptshhhs.sCtsCphptppcLN-LFRElWshccs-LllLulYLNp.KhsDllpNl.pC..Ct.t.t.....pCpClp.plc.....lDlpuhKlsLhhcLFhsss.plhcLhWuLla.osphYsphhtshh........sssthlcphsthaapN+p+IlchLapplc+l-alcphh.chssscphlp..plps....................................sscsDshp.cpp....................phlpsFatpYspshplLp+a.NVWWDKLIltRp.sDDLsoWLTRFYhRlhhoK..lslpshsptalpplVpGYLYFRhFTNFNhsNShslhHFsASLuIPoDYEKhClYLsGcPssGKSShFELL-p.lllVHKpDs-pYshsK.+ETsEhEscKh.SQLYVINEhKhCs-oFFKopADSTKSsSssRKYpGppKYEANYKlLIlNNc..PLaIsD.YDKGVpNRFullYhDHpFp.-sh.FsGSVYcHhcsK+YP.E+shh-pLtsPVRlFLuHlLhY+RsP+DGYV.YKslLpsDssapHNLtCLslNNoslpALlYVLpV+...c.us.........thlsEsKlpchIchAssaVcshlH.ph+.....Kpss..........tphLhs-FK+Kap...KaYsscsKhahNLsMAhscpDFNhshPpFKs	......................................................s.Ihpplhpsh....p.c.p.shpshtsssplll+NstTt..p++hhcphp.Fppllsshpsp.stst................................t........t....t.t..h.................................................sHsWshpsNhF.shhV+PFlhp..cpY-t...lp.c..tlshpcFhtSppstasNcsspuGDYhYWPN....huloahGWplaLhhpFsIslsshIPlhHp+pLGsVsLFshsPc......h....FLslEhsl.sssc...ppLFVNG+ohFscp.p........-sLF.lphs....ssssusCKhtscLVhS..sKshFcYI+DsI.NLppClTsscYppllp.lsLppLRhFspps.hsstshsttpph..........phh..IosSSEphc.lpppIspslttIp-tMlcshsppp....tsss.plL......ppYhppSsahNFcaLlhllW+hlp+ppch..papcTDIKLalELLC...........-pl...ass..............ct..shppsht+CcPYhphshplFp+hCsphphFps.s......h.sLuhYauIHahIYhchss............WsaTacsshs...CtlsspVlstGFF+Kl..hsspsshVFNGK.HY..hVK...KDDDLaKl.hppss.shplsslKFNNWKYhYhTcpGVaNlhpspa+ssCPFllGsTLhpshpchs-..pYLPcsshsaMLssucpEhpIh+hYHhAKlCRDl+hl+sNhthh.hhs..sCtpCp.ptp.pLNplFR-lWshscppLlhlulYlNc.KhpDllpNl.+C..Cptt...........pCpClp.plclshhAhKlsLhh-LFssss.pl.pLhW.Lla.ssphYsphhh............sssphlpphsphhhpp+hcIlphLapplc+l-al-.hh.phss.phhlp.lpp....................................................ttpst.t.pps...................phlppFatpYspshplLpKa.NVWWDKLIltRp.sDsLsoWLTRFYMRlhho+..hs..lpsYs..alp..plVpGYLYF+haTNFNhsNShhhhHFsASLuIPoDYEKhslYLsGcPsSGKSSFFELL-p.lllhHKpDs-pa.shs.p.+-Ts-hEssKh.SQLYlINEhKhCs-SFFKspADSoKssSssRKYpG.pKYEANYKhLIlNNc..PLa..lsD.YD+uVpNRFsllYhDHpF..-sh.FsGSlYpHhhsKpYP.E+shh-p.LtpsVRlFLuHlLhY+RsPpsGaV.YKslLpsDshHpHNLhCLslNNoslpALlYlLpl+...csus.........thlsEpKlpchIphAs..alcphL.Hsthp.....Kphs..............tphLhspF+cKac...+hYpt.csphahNLsMuhscpDhshs.hPpF+s....................................	0	0	0	0
+1335	PF04838	Baculo_LEF5		Baculoviridae late expression factor 5 	Finn RD	anon	Pfam-B_5141 (release 7.6)	Family	\N	25.00	25.00	27.80	50.60	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.19	0.71	-4.47	20	57	2009-09-11 05:38:18	2003-04-07 12:59:11	7	1	56	0	0	56	0	153.60	56	58.32	CHANGED	shsLFplFpcFRcscsYpcLIpaLlpNYPsNVKNKTFNFsNTGHLFHSLYAYlPulos..KERKQIRLp.-CIcKLFpNTpNDFKLYsElFchlp...spth.ppCPCpLlppRhpphpsYVcslpsKpFDsKPsKLKKEsIDsILaKYSlNWKslLhKKKh	....hsLFhlFpcFRpppsYppLIcFLlpNYPsNVKNKTFNFsNTGHLFHSLYAYlPulosh.KERKQIRLp.-ClcKLFsNThNDFKLYsEla-hIp...ppth.ppCPCpLlhp+hpphpsYVcslpsKpFDsKPPKLKKEsIDsILaKYSlNWKslLhKKK.....	0	0	0	0
+1336	PF05073	Baculo_p24		Baculovirus P24 capsid protein	Moxon SJ	anon	Pfam-B_6005 (release 7.7)	Family	Baculovirus P24 is associated with nucleocapsids of budded and polyhedra-derived virions [1,2].	21.30	21.30	21.40	38.90	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.32	0.71	-4.72	26	59	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	53	0	0	55	1	180.10	39	86.02	CHANGED	FpYssc.slEVhIIpN.....s-sDpDGYlElsAAA+LLuPhsp.+shsss.LWsNstsSaKLp+NNKNYlHsFuLsKYLSsYshssp..p.spYhsLKpLlsDLlhGsQsp.....shDP.......Ls-IKsQLCslQEslsps..........................................................................tsppsshhuslsuhL-hlKo.lpsDlssKlsFu	...FpYssc.slEVhIIpN.....s-sD+DGYlELoAAu+LLuPhlp...hstusLWsNstsSaKLp+NsKNYlHsFuLsKYLSsYshssp..p.s.pYhsLKpLlsDLLhGsQup.......lhDP..............Ls-IKsQLCslQEsLsps.sths...............................t...........s............p..p.htphlpsc.ts.p.hhs.shsshL-plKs.h................................................	1	0	0	0
+1337	PF04766	Baculo_p26		Nucleopolyhedrovirus p26 protein	Waterfield DI, Finn RD	anon	Pfam-B_6066 (release 7.5)	Family	Family of Baculovirus p26 proteins. 	19.10	19.10	21.80	21.80	16.90	19.00	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.53	0.70	-5.12	25	100	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	55	0	0	98	0	209.60	31	74.22	CHANGED	hsVpY..sVsasp+plslhphcscsVpl+VhsPttps.....tD-s..Lstl.HpFPGVATsllFPpl.ppsstlpVhLss....GsLhcspss..+lahNaHsap+RhVYGQLsulslss...plts+lYlGAPIFpss.+.LVSVVTspa.sDhtcshslhPVTGhRtsuhlSGphphDst...VhVpchcsshSVYGppQLPY..........tlKtaAhst.sst...tshscslhlFas..cc-VpIslscGpFEIs+lRlsGPhlss	......................................h.lp...p.h......t....h.hh............p.t...................h-pl.HpFPGluSs.slhsp.l..pptoslpVh.sc.....h..hchhhs....+hha.saHphsKRalaG.LPshtss-......hh.hLhIGuP....................Iacpc..p..hlSlVTtRa..cs.t...tt.h....haPloGl...GhhSGplsl-ss...lphcpLcsGhuVYG+hQhsY............slKphAhphs...........shhlhhp..pp.l.lsh....s.thph.+hRh.s.hh..........................................	2	0	0	0
+1338	PF05214	Baculo_p33	Baculo_P33; 	Baculovirus P33	Moxon SJ	anon	Pfam-B_6583 (release 7.7)	Family	This family consists of a series of Baculovirus P33 protein homologues of unknown function.	25.00	25.00	63.60	63.60	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.75	0.70	-5.10	18	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	57	3	0	62	0	241.80	45	97.07	CHANGED	Is.TPLhtRYKsSFhLasFRhLDhhRsuPSpcLpplLspElpYLYplsClIsY+-sQps-l-pLhpWshsLss-.hcL-phKhhah-KhppLNL+shpPpcYsaoFoTIWDoIHaLsLlsDDMVtNR..cphsh-hlptpl+phKhlFYNlFhhL.CshCpcHYLTVcuF.haplERIElALaRE+.hGEslhhVD.......E.lstspsscNlLh+athLYsSMlFHNHlNsYR.IQ+Nhcs.s..NapRM-WshYKpLLsl	.................................IP.TPLhs+YKDSFhL...asFRhlDhlR.su.SpcLsplLusElTYLYclACLItYKDlQppElppLhpWuhslstc.hcL-Qh+lhFh-KhpELNLRuhQPKsasYoFoTIWDoIHFLuLllDDMVtsR..cKhsh-hltppL+phKslaYNlFFhLpCshCRcHYhsVKGalIhpIERIEluL...RE+......aGEsIhhVD.......................-..hstsssscNlLMKpthLYsSMlFHNHINsYRaIQ.............RNhcsPs..sap+Mc.........WspYKphLpl.............................	0	0	0	0
+1339	PF02961	BAF		Barrier to autointegration factor	Griffiths-Jones SR	anon	Structural domain	Domain	The BAF protein has a SAM-domain-like bundle of orthogonally packed alpha-hairpins - one classic and one pseudo helix-hairpin-helix motif.  The protein is involved in the prevention of retroviral DNA integration.	25.00	25.00	25.10	33.00	24.40	20.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.86	0.72	-3.68	9	197	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	94	13	127	159	0	83.60	53	87.26	CHANGED	MsoTSQKHRsFVuEPMG-KsVssLuGIG-sLGt+LcspGFDKAYVVLGQFLlL+KD.E-LF+-WLK-oCGANu+QAs-CasCL+EWCssF	..........M.sTSpKHRsFVuEPMG-KsVspLAGIGcsLGp+LpcpGFD...K.............AYlVLGQFLlLKK-.E-lFp-WLK-.sC.GAssKQupDCatCLp-WC-tF...........	0	50	58	88
+1340	PF05112	Baculo_p47	Baculo_P47; 	Baculovirus P47 protein	Moxon SJ	anon	Pfam-B_6441 (release 7.7)	Family	This family consists of several Baculovirus P47 proteins which is one of the primary components of Baculovirus encoded RNA polymerase, which  initiates transcription from late and very late promoters [1].	25.00	25.00	65.80	65.20	19.90	18.40	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.09	0.70	-5.03	21	58	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	57	0	0	59	0	307.50	47	78.87	CHANGED	hFsphhphsSQhLPQCCKYLscsLshYhLa...hp....ths.stshahlccslpVctEGFVphppphVhFclspl.sp...uTPcDL-hYlcsoR..pl.osHctplhcLlh+DRWaKGDFsRL++hLs.pDsssLlsFsCNsLWERGYEsaYTLGQQLSIRITTKLIQSGLDFKH.Qsssss.....ts...............RGWssptFEKhluSIoSlSDlIKRHKhSpKYIlLElssspssphlchLhcppFslIpNsphsNVChIpl.D-DKNShpYLpKLupLIpp+llNVLFVTDlEaYl+pssahFYLYNSLKFYYYCLKNKFVF-hpDYEhlFL	....hFsphhphpoQ.LPQCCKYLs-sLshYhLY....hp....shss.ststhhlscslpVcs-GFVphppshVhFclspl..sp....uTPcDl-pYlchTR..sL.osHDtpllKLlh+.DRWaKGD.hsRL++lLppp-Vs..sL...lpFsCNVlWERGYEsHYTLGQQLSIRITTKLIQSGLDFKHQ.sssss..s.ss................RGWsstsFEKhlsSIoSlSDlIKRH+hupKYIsLElsssphsphlctLhpppFsllpNsphsNlChIpl.D-DKNSh.YLpKLspLlpsKllNlLFVTDVEaYh+pspahFYLYNSLKhYYYCLpNKFVF-tpDYEhlFL...	0	0	0	0
+1341	PF04878	Baculo_p48	Baculo_P48; 	Baculovirus P48 protein	Mifsud W	anon	Pfam-B_6510 (release 7.6)	Family	\N	25.00	25.00	56.10	55.70	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.47	0.70	-5.52	23	56	2009-09-10 15:38:45	2003-04-07 12:59:11	8	1	54	0	0	53	0	376.70	46	98.32	CHANGED	ppaplpYsLRFpK.....tsshppVsFpspLopsEIDSLsFLhucYFDQpphlsl.KGLTFFsEFNKCI-sIKpsFEs+p...-ss.-VKpIFslFL+cEFhsQVPsFphIMpYLppYYKPlssP.slst.l...Cs.pCs.hs+lpCLpCKssYlSsulohhDsulQ-GWDIFLRPMhGlPLhhalLlKT-as..cs-V.FNsDslITNsFsQFFYNLLCDKAsshYhsaKtCpPLlc-C++sshuLpsc-lEhLLshL.Nssohso.......KLasPFKpFM.chshpTKlK..KlNKlAuslFhGFYLRhYLEAtssK.......................shsssELElRNVCRhIh+cYs-cpFEphlpKLpsIKtDLhh.lhpphIVPEphIR+LhsKYsLDpDluhLLppsV	.....s.hplpYsLRFsK.....hcshpsVsFpspLopsEIDSLsFLhS+YFsQpphVsl.+GLTFFsEFNKCl-sIKpsFEs+p....-Ns.....-lKpIFSlFL+.cEFhsQVPpF+pIMpYLppYY+PhssPslstl....Cs.pCs..........hs+...........l..pClpCKssYLSsulSshDsulQcGWDIFLRPMFGlPLhlalLl+T-as..csslFNsDs....LITNsFsQFFYNLLCDKAsstassa..KtCpPLlc-C++sssuLpsp-hEhLLshL.Nssohso.......KLasPFKpFMhchuppTKlK..KlNKlAusVFhGFYLRhYLEutssK....................................shosuELElR.NVCRaIhp.cYs-cphEphlpKLppIKtDLh..lhpphIVsEpaIR+LhsKYpLDp-luhLLppNh....	0	0	0	0
+1342	PF04583	Baculo_p74		Baculoviridae p74 conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4744 (release 7.5)	Family	Baculoviruses are distinct from other virus families in that there are two viral phenotypes: budded virus (BV) and occlusion-derived virus (ODV). BVs disseminate viral infection throughout the tissues of the host and ODVs transmit baculovirus between insect hosts.  GFP tagging experiments implicate p74 as an ODV envelope protein [1,2].	19.40	19.40	19.50	20.40	18.30	19.30	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.58	0.70	-5.18	25	93	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	75	0	0	91	0	236.70	46	37.84	CHANGED	s..psss-s-.LEsIIspFLEDauLlhGIhTslGF-hL.sslcsMLK+INosLIPtLK+hLLsoS+RlTsRLLGETYKAAllHshNRhAIKTlSsVAKAhsRhuhpAuSVlGIlLIhlTIuDLVLhlWDPFGYsNMFPR-a.DDLSpoFLoAYa-Sl.sssoRDlIEFhPca...Fs-lV.....-..pD-.......hhh-ohhall-YluuLEVNSNGQhLphscG-sIsD..FDEtoLVGuAL.ASouhYTph-FhtYTpRHNclLh...ssp	.........................................st...s-pcL-sIIspFLED...aullhGIhsshGF-hLhsshKsMLK+INosLIPhL+phLlssop+VTsRlLGE.TYKAAll+shN+....lAIKTlossAKAhTRluIpAu...SVlGIlLIlhTluDLlLslWDPFGYNNMFPR-FPDDL....SpoFLoA...Ya-Sh.s.psoR-lIEFhPEa.Fs-hl........-..s--...p....hhhpohhalh-YluuLEVNSsGQhLphpcu-sIpD...FDEhoLVGs..AL.ASSuhYT+h-FhpYTtRpNpll...p....................................	1	0	0	0
+1343	PF04513	Baculo_PEP_C		Baculovirus polyhedron envelope protein, PEP, C terminus 	Kerrison ND	anon	DOMO:DM04337;	Family	Polyhedra are large crystalline occlusion bodies containing  nucleopolyhedrovirus virions, and surrounded by an electron-dense  structure called the polyhedron envelope or polyhedron calyx.  The  polyhedron envelope (associated) protein PEP is thought to be an  integral part of the polyhedron envelope. PEP is concentrated at the surface of polyhedra, and is thought to be important for the proper  formation of the periphery of polyhedra.  It is thought that PEP may  stabilise polyhedra and protect them from fusion or aggregation [1].	38.00	38.00	38.00	38.40	37.80	37.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-10.97	0.71	-4.35	23	57	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	54	0	0	54	0	137.80	34	43.32	CHANGED	lsslsQL..slssuNQalELoNhLsAI+hQssplhupLssll-slpspLsslss-lppLlsplss......clsshsssLssAlNpLp...-slRN-LTslNSlLsNLsSSlTNINuTLNNLLpAlsul....shGslsphhsshhss.........lppllsh	...........hsslNQl.....slNsoNpalELoNhLsul+hQNsplhutlsphl-slpspLsslss-lpplls-lss......pLsshsssLssAlNplp...cslRNELsslNSlLsNLsSSlTNINuTLNNLLpAlssl..........shG.slss...thpshlsp.........l.pllp......................	0	0	0	0
+1344	PF04512	Baculo_PEP_N		Baculovirus polyhedron envelope protein, PEP, N terminus	Kerrison ND	anon	DOMO:DM04337;	Family	Polyhedra are large crystalline occlusion bodies containing  nucleopolyhedrovirus virions, and surrounded by an electron-dense  structure called the polyhedron envelope or polyhedron calyx.  The  polyhedron envelope (associated) protein PEP is thought to be an  integral part of the polyhedron envelope. PEP is concentrated at the surface of polyhedra, and is thought to be important for the proper  formation of the periphery of polyhedra.  It is thought that PEP may  stabilise polyhedra and protect them from fusion or aggregation [1].	23.90	23.90	25.30	68.90	20.80	23.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.10	0.72	-4.00	16	82	2009-09-11 22:40:04	2003-04-07 12:59:11	7	2	53	0	0	79	0	113.00	28	41.17	CHANGED	-sssVPlha..ssh.slWVGA-ElLpIL+ls.sstlp....slPpscKphhpcLps............ss-usKhFlTtlGlulLsuRs.s...........................................ctushhsshFlsDshp-hp.......ssp.hC	....psssVslhap.ssh..shWlusDEllplL+hs.tsshp....slPppc++hWpDhps...........sshsusKhFlshhGlulLssRs.s........................................................................phschhhshFls-shhphhtp................................................................................................................	0	0	0	0
+1345	PF04501	Baculo_VP39		Baculovirus major capsid protein VP39	Kerrison ND	anon	DOMO:DM04345;	Family	This family constitutes the 39 kDa major capsid protein of the Baculoviridae [1].	21.60	21.60	22.20	49.60	20.00	21.50	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.01	0.70	-5.42	16	65	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	0	63	0	287.40	41	92.57	CHANGED	MALVssGssssRhp.NaCIFuuV.pP..FDsCtsYpSPCSsDAosDDGaFICpYHLShcFKMEKMsLPIPDu-ss..tYhRTlG+SLVsHpspuscRILIPTpsNYpoVLNlsuhsluEQLIhHhIYsNpsp.....hscICppL+hsE.pFps-hhplVEplYssTtplLuhTsPstYCopVss.sssRhassss..............ts.....ssu-psasshPsFl+NLIs+sVAPEshpIs....scsLhLRNCsTCtIs.ssGLVAss.......cLYNPVcP+YhhttN-NhLpIcNVLKFcG......NusALQ+.sLuRYEpYPlhVPLhLGpQllsops	.........MALhsss.tspchp.NhCIFtul.ps....FssCtsYsSPCSsDA..sp..c..DGaFICsYHLuphFKhpKhslsIPDu..csN..papholG+SLVspp.s..pu....pRILIP.opsNYpsVLNlsshs.sEpLlaHhIYsNpsp...........................pplCptLphsE.pFpssh.tllcplassTpslLuhssPst.aCupVsp.sssRhassss.................sp.....s.sppsasshPsFLpNLIp+sVAPchhpIs....spsLplRNssTCtIs.ssGLVAss.......pLYNPlpPphh...p.hp.p..NpLpIcsVLcFcG......su.ptLQ+.sLspYEpYsl.lPLhLGpphlsp..s............................	0	0	0	0
+1346	PF04913	Baculo_Y142		Baculovirus Y142 protein	Mifsud W	anon	Pfam-B_6688 (release 7.6)	Family	\N	25.00	25.00	30.60	30.00	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.57	0.70	-6.13	17	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	57	0	0	58	0	445.90	43	96.79	CHANGED	hsL-cc.pLKYLFLuSYFcL.ts.phlss-scsFIt.-YlcsNFp.ls-ssLlpYlsYLpshpLKpll.sDposshFKYlKPQF+FlCsRc.slDIlcFD.s+lYlpPsTslYATNhFVpsPppFphhlY..ptFs+Vas.cRpFVsssppasl.hsGspGalF-cuYlDWsGl+hCpsspl...psspaPYRLYLlGEtMAp+FlcpNI.hs...........pschlLKNFaKGLPL...h+ssaclINSK+FsTcKPNclF-EhppELsspssalKFIQRDYIYDA.sFP-DLL-LL.N-YhTpTSlaKaIpKFh-sp...phts..hsEIVlDRYuVs+YRKh.l+h-ssshaP.shphspsuYIFlpsDhlQI+GTLNAFYlP+ppll.ILAsNsLFGusclL............cFD..p.LlsYppsssPh+lst-hYhlstppKlYLs+ahFus.slPAYLlIRGDYE..oSp.....hKsLc-LpNsWVpNTLLpLhl	................................................................sL-pc.phKYLFlsoYFcL.ps.s...h...lss-spsFIp...pY...lpsNFp.ls-tsLhpYlsYLsphpL+pll.s-p.ssshFKYlKPQF+FlCsRs.slDIlcFD.s+hYI+PsTsVYATNhFVssPpchhhh..lY..scFs+Vhp..p+hFl...s.sssphsl.lsGssGalF-sAYlDWsGV+MCsss+l.....psspaPYRLYLlGEtMApHFlc..sNIhhs..........sssshhLKNFYKGLPL...h+spapllNSKKFsTcKPNcl.F.sElcpELssp....ssalKFIQRDYIYDA.pFPsDLL-lL.N-Y.hTpTSlaKhIsKFhppp.......p.sshhpEIVlDRYuVs+YRKL.IKh-.sshhP.shtts-suYIFlpsDl.lQI+GTLNAFYsPp.plh.ILAsNpLFGuTclL............cF-..p..LlsYppspsPh+lss-sYhVstppKlaLs+ahFus.sVPAYLLIRGDYE..oSc.....hKoLc-LpNsWVpNTLLpLhl.................	0	0	0	0
+1347	PF04684	BAF1_ABF1		BAF1 / ABF1 chromatin reorganising factor	Kerrison ND	anon	DOMO:DM04689;	Family	ABF1 is a sequence-specific DNA binding protein involved in transcription  activation, gene silencing and initiation of DNA replication. ABF1 is known to remodel chromatin, and it is proposed that it mediates its effects on  transcription and gene expression by modifying local chromatin architecture [1]. These functions require a conserved stretch of 20 amino acids in the  C-terminal region of ABF1 (amino acids 639 to 662 S. cerevisiae  (Swiss:P14164)) [1].  The N-terminal two thirds of the protein are  necessary for DNA binding, and the N-terminus (amino acids 9 to 91 in S.  cerevisiae) is thought to contain a novel zinc-finger motif which may  stabilise the protein structure [2].	24.90	24.90	25.20	25.10	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.98	0.70	-5.65	2	57	2009-09-13 16:19:24	2003-04-07 12:59:11	8	6	27	0	35	55	0	198.70	24	64.86	CHANGED	MSLYEYpcPIINKDLAtsDPV.uQpRoFPTLEAWYDVINDYEFQSRCPIILKNSHKsKHFTFACHLKSCPFKILLSaQGs.sSspstDGSPtshsGDttuppptpN........HpNGHTN....utDshuEpE..pDDEDDDAAVTAAIAAAVAAVADSQETIKGPFsVTKIEPYHNHPLESNLSLQRFVLoKIPKILQVDLKFDAILESLCND-DNTVAKFRVAQYVEESGIlDIIKQRYGLT-AEMDKKMLSNIARRVTT.KARFVLKRKK-GVYhhPsuHQloGuDpHQhQhpH......pHQHQ....pQ+phQHpHQpQpQp.QHQpQHQpHVsssppVYQsRItS.SDpD-uulHNLDDsNVRV.AAAAAAAAAALQSR-sHsoE-LKhshtpsQD--ul-sss.sSKRQLHRp-RDRVAEALKMATRDILSNQsVDSDVNVDVDLVTGHKQLSPHDDMAEQLRLLSSHLKEVEAEENVSDsNLKKDDl.DENIQPELRGQ	............................................................................ss....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pt...t...............................................................................................................................	0	3	17	32
+1348	PF02179	BAG		BAG domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain present in Hsp70 regulators.	23.40	23.40	23.40	23.40	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.53	0.72	-3.87	63	795	2009-01-15 18:05:59	2003-04-07 12:59:11	11	16	274	24	498	779	0	77.20	24	25.51	CHANGED	plpplhsclpp.ltsplpph.........tsp...ppcpchhhls.EhLhpt.LlcLDul.p..spGp......slRptRKphl+clQshlcpLD....thp	.......................................................lpplhpclpp.ltspltph....................................ts.p...pppcphhtlp..EhLhp..LlcL.Dul.c......spGpt.......slRptRKphl+clQsllcpLDth.t.................	0	102	206	335
+1349	PF02923	BamHI		Restriction endonuclease BamHI	Griffiths-Jones SR	anon	Structural domain	Domain	\N	22.80	22.80	27.00	27.00	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.01	0.71	-4.30	3	18	2012-10-11 20:44:43	2003-04-07 12:59:11	10	2	15	9	8	16	2	136.40	41	74.24	CHANGED	M+VcNcEILl-sGclssc...IpSIhsEVcsSIcsslWPAsScsFsINsT+Ku.NGVKPIK-pCMpHLc.paGWaLEK+LDIhKs-pKP.GPIDAVK.l....usKtFAlEWETGNISSSHRAINKMlLGMLcGcIIGGILILPSRpMYsYLTDRVGNFcELcPYF-l	........................hcl.pp.hh.pttp..h...pp...htphhs-lhpuIps.haPssspsFhlNs..scKs...NGVhPIKp.ChphLc.phsWhhEp.lcl.hhptp..GPlDshK.h....p.+hhuhEaETGNISSuHRuhNKhlLGlhcG.l.hulllhP.+phh...Y...LTDRluNFcELEPYFp..........................	0	4	6	7
+1350	PF00373	FERM_M	Band_41; 	FERM central domain	Bateman A	anon	Bateman A	Domain	This domain is the central structural domain of the FERM domain.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null --hand HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.53	0.71	-3.95	56	4264	2009-09-17 09:40:39	2003-04-07 12:59:11	13	246	174	84	2246	3702	4	127.30	24	12.59	CHANGED	-.t...hp-shphphhYhQs+psllp...sch...........ssp.-pshhLAuLthQhphG.chs.tpptsts..htt..th...................................................................................................................................................................................ls....................................hhpphppcp.hppclhptap.phps.........h..ottcAch....palphspp......L.stYGsphF	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hp-phs..hhhha.l..Ql.+pcllp.......Gcl...........Cs....css..hhLAu..htl.Q..s..chG...Das...pt.p.tt..s..hh.tpt.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhP.................................................................t...h...p...s..c.........p.......h........cc.c.lh....phap....ph.p.u..............................h.....o.tc.Ach.........paLp.h.sp.p......L.thYGlpha......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	564	750	1407
+1351	PF03114	BAR		BAR domain	Bateman A, McMahon HT	anon	Psi-blast P25343	Domain	BAR domains are dimerisation, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like Pfam:PF00169 and Pfam:PF00787 domains in beta centaurins and sorting nexins respectively.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.52	0.70	-4.85	28	2173	2012-10-03 12:17:00	2003-04-07 12:59:11	13	82	313	19	1287	2310	1	214.10	18	40.80	CHANGED	hpKp....hsRssQhhppKhGtuEpTc..DccFcphEc+hcthpptspclhccsptYlps..shtscph......................hLupshhchucphupcss...u...........sh.phupshcpl.uphhcshptplcpshlcPlpphh.sphpslp+plcKhps+hLDaDsp+p+hp+hp...t.................--EhctAppca-chs-.lpppl.slhstcsphl.splpshlptphcaappshphLpplptpltt	....................................................................................................................................................h..p.h...t...p..h..s.................s...p.t...Tp......-.......t.......p.a.pp.h...p..p..hp..hpp.........spcl.cph....p....t....h...lp...s..........s.h..ptpph.................................................................................hlup.sh..c..h...h..pth..s.......ttpt.......s.................................................................hh....ph.spshc..pl....sp....h........h......p..p.h...p........tp...............l...p...pphl...p.PLp.phh..spht....sl.......p..c...............th+.......K....hpp...+...h.......l.......D.aDt....t+p.+.h..p........p.hpt..tp..t...........................................................-cElc..pA..p.ppa-...phs.......ptl.....p.p.......cl........p........l...h...s..t.c.h.phh.sp.hps.h.h.....p...hp....h...p....aappsh....phhppl.....t........................................	0	333	558	919
+1352	PF01337	Barstar		Barstar (barnase inhibitor)	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	21.00	21.00	21.30	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.93	0.72	-4.14	52	1251	2009-09-10 16:56:04	2003-04-07 12:59:11	13	10	1143	47	253	726	26	85.60	29	72.31	CHANGED	ltlDhsphpscpslhptlupph.sFP.saaGpNhDALaDsLosh............sphshhlhhpthsphpph..cphtt...lhplhc-spcph...ss.t..hp	.......................hhDhsclpspp-hacphupsh..uhs..pth..G....c.NLDuLaDsLts..................hhshPlpI.asphsp.t..p+............c.c..a.ss...Ll.lhc.-.Ap-ch...tt......thh.........................................	0	59	152	209
+1353	PF00967	Barwin		Barwin family	Bateman A	anon	Sarah Teichmann	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.95	0.71	-4.43	8	153	2012-10-01 21:39:58	2003-04-07 12:59:11	12	6	58	2	47	226	1	108.50	60	69.81	CHANGED	SAoNVRATYHlYNPtp.NWDLs..AsSAYCAT..WDAsKPhuWRpKYGWTAFCGPuGPRGQuSCGKCLRVTNTuTGApsTVRIVDQ..CSNG....GLDLD.ssVFpplDT.sGhGYQpGHLsVNYQFVsC	...........................................AsNVRATYHhYsPtp.......sWDLs..ssSAYCuT..WDAs...KPLu.WR.pKYGWTA..F.C.G...P...s..G......PpGpsuCGK...CLp......VT.....N.....T....u...TG..Aps.........TsRIVDQ...C....SNG.......G...LDLD.ssVFpplDT.sGtGhppGHLhVsYpFVsC...............	0	6	28	38
+1354	PF04865	Baseplate_J		Baseplate J-like protein	Mifsud W	anon	Pfam-B_4777 (release 7.6)	Family	The P2 bacteriophage J protein lies at the edge of the baseplate. This family also includes a number of bacterial homologues, which are thought to have been horizontally transferred.	20.50	20.50	20.60	20.50	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.59	0.70	-5.03	136	2290	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	1421	0	441	2037	229	212.60	22	56.27	CHANGED	pustL.Dphuth.hs..ltR..hsss.A.ssshh.sss...................................................................................................................usshEsD-s.......hRpRlhhshcshss....uGspssYphaAh...........................ss.ss..............Vscutshss...............u..............................sGs..Vplslls.p...................su......hssspllst.....................Vpshl...........pt-sl..........RPlsc.pVpVtusphhshslssphhhh..sss.spsht.sspps...lpsahtstpph..........Gts...lhhSt.l..hus	..................................................................................t....Lt.hst..hs..h..Rh.ht.u...p.s...h...h.........................................................................................................................................................................t............................................................Gss.....hEo.....Dps.......h.RtRh.t..s..hc.s..hss....uG.s...p..s.sYpha.Ah............................ss..st..........................Vs.cstshss............u...............................................................................................sus.....Vp....l.hllsp..........................su..........hsspsllst..........................................................................Vpphl.........................-sh....................+Pl....s.....s...pl..pV.tu.sthhshplpspl..hhh...sss.p.......sp..sht.....shp...tt........lpta.ht.t...th...........stt...l..stl.....................................................................................................................................................	0	128	281	374
+1355	PF01586	Basic		Myogenic Basic domain	Bashton M, Bateman A	anon	Pfam-B_427 (release 4.1)	Family	This basic domain is found in the MyoD family of muscle specific proteins  that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding [1]. With 12 residues of the basic domain involved in DNA binding [2]. The basic domain forms an extended alpha helix in the structure.	25.00	25.00	27.10	26.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.47	0.72	-3.26	7	456	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	147	4	145	408	0	84.90	40	34.53	CHANGED	MELh.s....hs.......hF...s.pp....FYDupsh.sschp..hhEsht...sp.ssLp.........P-s.ptppE-EHltAPs....cHpsG..pCLhWACKsCKRKosssD	...................................................................................................................................................................F.............ah.-...s...sh..sc.hp...hh-s..s....h.p....s..sL.p.........................s-.t....p...s.s....p...--..E...HVtAPs.............s.pHpsG....pCLhWACKsCK.RKosssD...	0	21	30	72
+1356	PF02028	BCCT		BCCT family transporter	Mian N, Bateman A	anon	IPR000060	Family	\N	20.10	20.10	20.30	20.30	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	485	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.54	0.70	-6.25	145	4820	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	2128	17	801	3301	1081	459.80	34	85.74	CHANGED	VFhhSshllhhhllhsl.....hh.scthpshhsshhsalsspFGWaYllssshhllhslhlAhS+.aGpl+L.GsscscPEaSthoWhuMLFuAGhGlGLlFaulAEPlhHatss................P...ts......psto...pAA.p.AhthoaFHWGlpuWAlY.ulluLulAYata+.+shP................hplposh.hPllG.c..+.hpGs....lGcslDllAlluTlhGlATSLGhGshQlsuGLstlh.G.......l...s.s......shss.plhllsllsslhslSshoGls+..GI+hLSplNlhLAhhLllFlllhGP.ThallsshspslGsYlpsh............hthohhh...ts...hs......sss.................................................WhssWTlFYWAWWIuWuPFVGhFIARISRGRTIREFllGVlllPslhshlWaulFGuoAl.........thph.....puss.slss.............sttss.ssulFshlpph.............Phutlh....uhlsllLlhlFalTSuDSuohVluhloosG...st..sPsthh+lhWulhhuslAhs.LLhs..GG.......LsuLQsssllsALPFsllhllhhhuL.....................h+sLpp-	.............................VFhhoh.h.ll.h.h.h.s.h.h.s.h.....h.h.s.c.....t.stthhss..................h.hsalspshGWhallhsslhlhhsl.hl.s.....hSc.aGpl+.L.G..t.p.pcPEaShhSWhuMLFuAGhGluLlFaGsAEPhhaahs.......................................P......sh.........ps.to.tpAh...p.AhthohFHWGlpuWAlY.ulsuLslAY.Ftap.+s.h.P................h.p...lpusl.hPllG..c....+....h....p.G........l.G.chlDlhullATlhGlAToLGlGs.QlssGLphLa..u.......................l....ss..............shth.phhlIslhshlhs..lSshoGlsK..Gl+hLS.plNhhLAhlLll.hl.l.....l.....h.....G.....P.....T..hal...hs..sh...ssslGs.Ylp.s.h..............hph.oh.t..ts...hs.....pss.................................................................W..h.p.sWTlFYWuW.WluWuPFVGhFlARISRGRTIREalhGslllPshhshlWaulFGs.sAl......................hh..h..............ps..hh....slsp...................................ttss..ptu.la.thhpph...................................P.h..u..p.lh....shlshllhhlFalTouDSuohlluhhosps......................s..cs...s.hhhRlhWulhhu...............lluhs.LLhs......GG...........LpuLQsssllsulPFshlhlhhhhuhhKslpt...................................................................................................	0	247	506	695
+1357	PF02327	BChl_A		Bacteriochlorophyll A protein	Mian N, Bateman A	anon	Pfam-B_38317 (release 5.2)	Domain	Bacteriochlorophyll A protein is involved in the energy transfer system of green photosynthetic bacteria. The protein forms a homotrimer, with each monomer unit containing seven molecules of bacteriochlorophyll A.	25.00	25.00	234.40	234.10	19.20	18.50	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.33	0.70	-5.83	2	70	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	28	4	12	70	0	290.90	78	98.43	CHANGED	TTAHSDYEIILEGGSSSWGpVKGRAKVNVPsA.PLLPsDCNl+IssKPLDstKGhVRFoshIESlVDSsKNpLsVEsDIANETK-RRIsVGEGSloVGDFSHSFSFEGpVVNhaYYRSDAVRRNlPNPIYMQGRQFHDIlMKVPLDNNDllDTWEGh.pulpusGu.FsDWIREFWFIGPAFsAlNEGGQRIS.I.VNS.sspuGEKGPVGVoRW+FSHuGSGlVDSISRWsELFPs-pLNKPASlEuGFRSDSQGIEVKVDGphPGVShDAGGGLRRILNHPLIPLVHHGMVGKFNDFTVDTQLKIVLPKGYKlRYAAPQFRSQNLEEYRWSGGAYARWVEHVCKGGTGQFEVLYA	.........TTAHSDYEIlLEGGSSSWGpVKuRAKV.NVPsA.PLLPADCNlKIssKPLDstKGhVRFousIESIVDSTKNKLsVEsDIANETK-RRIuVGEGpVoVGDFSHoFSFEGSVVNMYYYRSDAVRRNVPN..PIYMQGRQFHDIlMKVPLDNNDLIDTWEGh.pulpusGA.FsDWIREFWFIGPAFTAlNEGGQRIS.IpVNu.hssESG..-KGPVGVSRW+FSHuGSGlVDSISRWAELFPsDpLN+.P.......ASlEuGFRSDSQGIEVKVDGshPGVShDAGGGLRRILNHPLIPLV..................................................................................	0	2	3	9
+1358	PF00452	Bcl-2		Apoptosis regulator proteins, Bcl-2 family	Finn RD	anon	Prosite	Family	\N	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.42	0.72	-3.89	72	878	2012-10-03 11:38:54	2003-04-07 12:59:11	14	11	175	146	362	880	0	97.20	28	43.78	CHANGED	Lpplu-clppphpph..apshhpplpl.s.tp..shph....FppVupclFps...........slNWGRlVulhsFuutlsh................chhpptt...sth...lpplsphhspal.ppphssWIpppG.GW	..................................................LpphG--hppp.hpp...apshhppLp....h.......sstp......shpt.......FtpVsp..-....lFpc.................................slNWGR.lVuha..sFuutlsh..................cshppph......tsh.................lp.plspahs.p.al.pcplt.s.W..ItppG.GW..............................	0	81	111	190
+1359	PF04538	BEX		Brain expressed X-linked like family 	Finn RD	anon	Pfam-B_3086 (release 7.5)	Family	This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals [2]. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in Pfam:PF07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way [2].	26.10	26.10	30.10	31.20	23.40	25.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.38	0.72	-3.79	20	315	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	27	0	152	306	0	126.00	29	85.30	CHANGED	M-.......KsppENEtcsp.sps+sE-t.............................................................................ppPhtss-tpcscGshRc.+ltcsh.pF+tDI.sRplss-Ehhct.sD-hpRhhEEhRclRpKht...............shHacp+cspsh.	..........................................................................Mp.psppENEsc.p..stspsEct..............................................................................................pcPhtss.spcsc...ssh+c.thtpsh.pa+.EDl.sRplssE-MhRt.s--hpRh.EEhRcl+pKht...............shHapp+cphsh.......................	0	14	14	19
+1360	PF04714	BCL_N		BCL7, N-terminal conserver region	Mifsud W	anon	Pfam-B_5900 (release 7.5)	Family	Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome [1].	25.00	25.00	29.00	28.30	19.50	17.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.48	0.72	-4.39	2	196	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	90	0	108	180	0	45.70	73	23.78	CHANGED	hsRShRAETRsRuKD-l++Vhpul-KVR+WEKKhVhIpDTsh+IYKWVPluu	........Ro..lRAETRSRAKDDIK+VMsslEKV..R+W.EKKWVTVG..DTSLRIaKWVPVo.p......	0	23	32	61
+1361	PF01869	BcrAD_BadFG		BadF/BadG/BcrA/BcrD ATPase family	Enright A, Ouzounis C, Bateman A	anon	Enright A & Pfam-B_5854 (Release 7.5)	Family	This family includes the BadF Swiss:O07462 and BadG Swiss:O07463 proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase Swiss:P11568. The protein Swiss:O66634 contains two copies of this region suggesting that the family may structurally dimerise. This family appears to be related to Pfam:PF00370.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.60	0.70	-5.10	19	4290	2012-10-02 23:34:14	2003-04-07 12:59:11	15	24	2197	20	1108	3723	293	259.00	21	58.92	CHANGED	lGlDuGuTso+sllhs........cpup.lhspshssu..................................................................sshptss.p.s.t.h.culppshcpuGhshp-...............................................................................................lthh..sssGhGhsshs..hstchhht...........chsspscGshhhhsssp....uVlsIuGpsopslthc.sGpstsashtuhshuspGphhtlsuctlshslcphsulstpus............................ps.tthsutssshutp.hhsthuus.tutcIlsshspslutplhshhpphushtt.......lhhsGGlups.shh.tl...l.pphhph..h.h.s.sthsuAlGAuLhA	........................................................................................................................................................................lGlDsGSTss+s..l...l..h.s...........p.s...t...p...l...l......h...p.h..h...t...h.s..................................................................s.sh.......................................h.......p...sl.p.p.h.h...p...p...h....t....h..t.....t...............................................................................................................................................................h..t..h..h............s..s..s.G....h....G......t.t.t...h...t..............ht...ph.hh...................................Elhsp..sc...u..s.t...t.....hh......s..sss......................sll.-..IG.G..pDu...K.sl..t..l.........c..........s.......G......t.....h...........t......p.............h......t.h..............ss..............tCu.u.u.s.Gu..a..lc.h..h..u..p.t.....L.p..h...s.l..p.....p..h......s....p..hu..psp.........................................................................................................................ps...hsl..s..u..c....C...s.V...F...A...p....o.p..l...p...s...h.....p.t.ss......s.t.pcI.h...suls.p...u.lsp....p....s....h..s..h...l...t....p...h...p.......t.........................l.shtG...G.....s.....h..t..s.............h.....h....p.t.....h.............p....t..h.......t..............h..........s...t..h.......sshGAsh........................................................................................................................................................................................................................................................................................................................................................................................	0	477	821	983
+1362	PF03170	BcsB		Bacterial cellulose synthase subunit	Mifsud W	anon	Pfam-B_3954 (release 6.5)	Family	This family includes bacterial proteins involved in cellulose synthesis. Cellulose synthesis has been identified in several bacteria. In Agrobacterium tumefaciens, for instance, cellulose has a pathogenic role: it allows the bacteria to bind tightly to their host plant cells.  While several enzymatic steps are involved in cellulose synthesis, potentially the only step unique to this pathway is that catalysed by cellulose synthase. This enzyme is a multi subunit complex. This family encodes a subunit that is thought to bind the positive effector cyclic di-GMP. This subunit is found in several different bacterial cellulose synthase enzymes. The first recognised sequence for this subunit is BcsB. In the AcsII cellulose synthase, this subunit and the subunit corresponding to BcsA are found in the same protein. Indeed, this alignment only includes the C-terminal half of the AcsAII synthase (Swiss:Q59167), which corresponds to BcsB.	20.10	20.10	20.40	20.20	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	605	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.74	0.70	-6.50	55	1096	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	931	0	189	915	40	545.50	33	75.33	CHANGED	sss...sspspshsFtplGh..sslsLpGspsptslsFslpsD.clVosApLpLsao..SPuLlsshSp....lpVhlNsplluslslsppps...phsshplslsPt.hhs..saNplplchhu+asts.CpssssssLWssluss.SpLsLshpslsl..tscLuhLPsPFFD..............tpstptlslPhVhsssss.splcAAuhlASahGshAs.aRstsFPshhs.......slPsps.....ulVhuossphsshl....shPs..h...sGP.......slthlssPssshs+lLlVhGRssp-LppAupuLshus..sshsGssstlsp......sRpPYDAPsal.o-RslphuELst....spsLpssGhtssslplshpl......PPDLahhpspslslsLcYRYoss...stssSpLslslNsphlpohsLss.t........h...hhspsshssppplplP...shhlsupN.......pLphcFshss.psu....tCpsstss..s..+usIss-SoIDhSsh.HahthPsLssFAsuG.aPFoRhADLS..cTslllPsp.....PsssslsshLslhGphGttTGhPshslplsss.....ss.ssh.pcc.DlLllGshss..shhhph.........sspl.shhhssspth.ht.s.....h.tth.h...t...ssttssssthsls...usushuslhGhpSPhsspRo........lVulh	.................................................................................................................................sts....ssppsploFsplu..ssshsLpG..hss.s.u.slpFshcuD..clVopAhLsLpYo.sSPuLl.ssp.Sp.........LpVh.lNsph..hus...l..s...lsccph.....p..........pshtphsIssh.hls..caNpl...pl..c...hl...u....+apc.....s...C.Esssos.............sLW.lclsps.SsLsLsapt.lsl...ps-LucFPsPFaD..............s.c.c.s.p..s...slsh.V.hs...s....s..Psss.......pAuu.llAS..WFGutus...aRuppFPVh.hs....................pLPsps............................ul..Vhuos-c..hPshLp.........stPs.....l......puP...............................slph...lsp..Pp.........s........s...h.sK.L.LVVh.G+s..-c-LhpAu+ulApus.........hhhpGpsssVsc..p.h.sRpPYDAP.sWlpoDRs.l.......shu...ELtp..........ppLp.ssGht.......ssslslslsL...PPDLahhcussls..hclpYRYo.s..........sp-sSphslslNsphlpohsLss.t...............hhpshh.ssctslsIP...slpluupN............pLchcFphh....s.....hsu..........sChshtss...ts.+ssIs.s-SoIDhSp.hhHah.hPcLt..hFuNuG.FPFoRh.ADL.S...pTh...sVhPcp.....PspsphpsLLshhGhlGs..tTGhsshsls.lscs.....ust....ts..cct.DlhllGshss....hhp...........................scpl..shhhpss.psh...htps............h...............tttttspst.thp....sssshsslhuhpSPhpstRsllsl..........................................................................................................................................................................	0	37	85	137
+1363	PF02138	Beach		Beige/BEACH domain	Mian N, Bateman A	anon	IPR000409	Family	\N	21.00	21.00	21.20	21.80	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.94	0.70	-4.95	145	1432	2009-01-15 18:05:59	2003-04-07 12:59:11	13	80	283	6	960	1325	26	252.20	44	12.87	CHANGED	T..pcWtptclSNF-YLhhLNhhuGRSaNDloQYPlFPWllsDYpSp..pl....Dl...s..sspsaRDLoK.PhG....uh.spcRhppht.pphpp.htp.t.....................................a.hYuoaYS..sshsVhhaLlR..l-PF.oshtlplQuGcFDhssRlF....pSlppsaps.s...ps.sDh.+EL...IPEFF.......hhPEhLhN.NphshG.h.....psp.lsDVhL...PsW..u..ps.st.....cFlhhpRcALEScaVSppLppWIDLIF....Gh+Q+GptAh.ps.NlFp.hsYpstht......thps...ppp...thpshlpshGQ....sPt.QLF.ppsHPpR	.....................................................................pcW.p.tc..ISNF-YLhhLNslA..GRoaNDL.sQYPVF...PWllsD...Y..sSc.....pL..................DL.s.......sPpsa...RDLSK..PhGs...s.cR.hptht.c+Ycp..hcp....................................................................s.a.HYGoHYS.ou.t.hVhhaLlR.h...pPF.ophhl...pLQu.....G.p.FD...h...s...DRhF..................pSlt.psWps....s.......pshsDV..+EL......IPEFa......................a.h.P....E.hL.hNtst.hs.hGhh......................pssphlsDV.LPsW......A.......ps....Pc.................cFlt.hpR.pAL.......ES-aVSpp.....LHp.....WIDLIF....GY.KQ......p.G...tAl....cAhN.VFa.hoYpGsssh...............................ptlpD...h.+puh.s.IpsFGQ.sPp.QLh.ppPHP.R..........................................................................................	1	439	568	771
+1364	PF00407	Bet_v_1	Bet_v_I; 	Pathogenesis-related protein Bet v I family	Finn RD, Radauer C	anon	Prosite	Domain	This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants [1]. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10 [2]: - Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1 (Swiss:Q8H1L1), an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones [3]. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine [4]. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber [5]. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens (Swiss:Q9AXI3).	20.80	20.80	20.80	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.78	0.71	-4.60	34	1250	2012-10-02 19:24:03	2003-04-07 12:59:11	14	8	180	62	290	1394	4	142.70	32	95.24	CHANGED	uhsGph.sElplpssAc+aa+hapt.cschlPcshsc.tIpulclhEG-hsss..GoI+pWsash.-Gc.cshKE+lEhsD-p.pslsapslEGclhpcaKpatsshphh.PKspGs.slsKhohcYEKhs-css.Ppchlch....stplsc-l-saLlus	...............................................shptEhss.s.lsss+la+u.hhh.-s....ssllPKl.hPp.slpolEh.l.E....Gs..G.GsG...........TI..Kcls.F.....s.............c....u..........s...h.pa.s..Kc+.l-tlDcs....NhthsYoll..E...G.s..s.l.s..c.t...lc.p.l.s.hc..hKl...s...sss......G...G...S.lhKhosc..Yc...s...ps..stt...............pc..hch........stslh+slEsYLlt...........................................	0	47	183	242
+1365	PF03494	Beta-APP		Beta-amyloid peptide (beta-APP)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	40.80	39.70	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-7.73	0.72	-4.48	2	171	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	48	133	33	165	0	38.90	89	6.25	CHANGED	.tc-pt.EVaHQKLVFFAEDVuSNKGAIIGLMVGGVVIA	...FRHDSGYEVHHQKL..........VFFAEDVGSNKGAIIGLMVGGVVIA.	0	1	4	11
+1366	PF00144	Beta-lactamase	beta-lactamase; 	Beta-lactamase	Sonnhammer ELL, Bateman A	anon	Prosite and Pfam-B_106 (Release 7.5)	Domain	This family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.82	0.70	-5.42	127	13942	2012-10-02 21:13:33	2003-04-07 12:59:11	19	160	3791	302	3910	15232	5643	321.50	17	75.55	CHANGED	lpphhpphht.............................hsGhs............lslhpsGchhh.th...............u....................shss......cohFtluSsoKshsussl.hthscpG................t.........lsL-csl.......................pcals....................t.stptlTlpcLhsaouGh........h.tt........................phhthhtth...h............sGpth..Ysssuhs.Llutlltpss..G.ps.....htphlpcplhps.................h..shpcsthssststptphstsh..t..............................................................shhusspDlt+ah.....................h....tthhsttthpph..........hshhtsststssthttsh....uhGahlsstst............................hhtpsG..........shushhhhsspp..........slslsh...lsNptt..ttttttsthhhthst	.........................................................................h.........................hsG.h.s................l.h.l...h..p....s...s..p..h.....h.h.p.ph.h...................................................Gh...................ts.h..t.t.t.............s.h.ss.................s.o..h..apl.u...SloK..s.h....s..u..s.hl..h......p....L.h..pc.G..............................p..............l.s..L..c..c...s..l...................................................................................................sca.lP.......................................t....t....s...t..p....t....lT.l...pp.....LL...s.H..o.....o..G.....l..s.........................t...t.h.h.ptt.................................................................tp.hhp..h...h..t..p...h.......h..t..ht................................................PG..s...p..ht...Y.u...s.........s..shh..lLuh.....l...........l..c.pso...........G..ps....................................hp..p.h...h..p...c..p..l.....hpP.............................................L.....u..h...p....p.....o........t.....h.......t.....s......s.....t.....s....t.............t....t......h.....s...h......s...h.............................................................................................................................................................................................ssuulh.oos.pDh.....t+ah.................................................h...t.t.t..h....t.t..p..h..h.p..th........................................h...h...h...t....h....h..........s....s...t........t..t..s.h.........................uh..G.a..h.ht.t.tt............................................................................................thh...t.+s..G..........thus.....h..h...h...h.....Ppp....................................ph.sls...h....h.s.Nt...................thh........................................................................................................................................................................................................	1	1339	2525	3318
+1367	PF01212	Beta_elim_lyase		Beta-eliminating lyase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.74	0.70	-5.27	53	4088	2012-10-02 18:26:03	2003-04-07 12:59:11	16	26	2725	70	1143	27402	8234	301.90	26	73.88	CHANGED	DLtSDoht.s.TsuMpcsh.stA..hGD.-.s.YusD........sstcLccpss...........-..............................lhGh-.ss..l..F..............ss.o.GTtANplul....hshs.p....pphlstcs.....uHhahcEs.uuhs.l..uGspshsl...ssp...s.............Gshslsclcp.tlct..s.........a.spssllslpsTps...Gpllsh.cplcplttls+cpG.......l.lHhDGARhhs..Au............sslsssl+Ehs..uh.sDulshshoKshssslG.ullshscc...........................................................alppthch..p+....hLGuth....R..psG....llsA......................................uGlhul-ps......hhphtcDpcp..AcpLup...tlpt........lsh......s.hsp..hs....spsphshltts	............................................................................................................................................................phhoDs.....ss.t.h...h.puh....h...t.....s......hG..D......-....s....Y....G....s....D..............s..s..t....p....L..p....c....t....h.t................c.............................................................................................l...h...G....h....c......su.......l....F........................................hs....s...G...T......t......A...N........l...s.l.......................s..h....h....c..........p....t...p....p.....h...l...s.sps............................u.H.h..h......h.....p......E..s......Gu..h....t..h........s........G......h....p....s...h....s....l.s.....s..pp.....................................................G..p...l...s...h...c..p...l.c...t...tlct.s.....................H.h.s.p..s..t.h.l.s...l...p..p..T.ps.........G..p..l.......h.....s.....h......p......p......l...c..p....l......t.p..h..s...+.....c...p...s...............ls...l..a........hD...........G.....A......R....l..h..p.......A.s..............................................ss..h..s...h....t..h...p...-...h.s..........p.h....s..D......s....h...s...........h........s...h...o....K....s...h...s....s...s....h..G....u......l.l.s...h.s.cc.......................................................................................................................................................h.l.t..p...t....h..p...h......t+.............h.h....u....u....t....h...........+.........p...t.....G........llsu........................................................................................................u..u..h...h....u..l...c.s.........h..h..h..t...c....s...p..p..p....A.p.p.l..sp....t..l.pt........h..s.h.....h..h...p.....s.....opthhs.....h...................................................................................................................................................................................................................................................	0	371	694	965
+1369	PF02929	Bgal_small_N		Beta galactosidase small chain	Bateman A	anon	Pfam-B_592 (Release 6.3)	Domain	This domain comprises the small chain of dimeric beta-galactosidases EC:3.2.1.23.  This domain is also found in single chain beta-galactosidase.	19.80	19.80	19.90	20.00	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.69	0.70	-5.38	21	2500	2012-10-02 23:57:29	2003-04-07 12:59:11	12	42	1440	273	453	2175	266	257.00	27	27.63	CHANGED	slp.utshphhFs+psGtlpshh.hpGpchLhp..sspssFaRAPTDNDhGss.s.ch......tp............WpsAGh.phppcl..h.s.ptt..............s-shlplphsathsshh...htsphsYplpssGplplslshpssts....lP..lPRlGlphtlsps.hsslpaaGhGPtEsYsDRppuuphGpapsslsp.hssYlhPQEsG.+s-s+hlslpttt.........stlhlsup.....FsFus...YotppLpp.ssHhp-L.tpctshLplDttphGVGG.DSWussVpspYpLts.psapasaslp	.......................................................................................................h.lpstshph.Fs+.t.s.G.hlspht...h........ss....p.......p.....h..lh..p........s..p........sF.aRA.s..hD.....ND....hs.....t.tsh...........................t........................W.p.s..s.s.ht.t..h.p.t...ph..t.h.ts.pp..s......................................................sts.....lh..s..p..h...s.h.....h..........h.s....s.....h..h...hpsphpYp...l....s..s.........s...G...p.....l...pl..s..h..p..h..p..h.ts.s...............hP....p...lP+lGhph....tl.....s......tp....h....sp...lpaaGhGPtENYsD+ppuuhhuhap...s.s...ls....p..h..a...p.....sY..lhPQEsGt+pssRahsl.tstt......................................sul.hlpup...............t.h.p.Fus............Y.......ot........p....p....L................p.................p......s........p......Hp...p..-L..p........t.....p..c..t...s..hL.slDttph.GlGu.sSWG..s..p..l..h..s..p..a..pl.h...pp..apaphhh.h.........................................................	0	131	310	401
+1370	PF02180	BH4		Bcl-2 homology region 4	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.50	20.50	20.50	20.90	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.60	0.72	-6.77	0.72	-4.42	11	223	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	58	92	80	246	0	25.40	54	12.65	CHANGED	huhssRpLVhcFlsYKLuQ+Gashtpt	.....u.sNRELVhcalsYKLSQ+GYsWst.h.....	0	5	12	29
+1371	PF02368	Big_2		Bacterial Ig-like domain (group 2)	Bateman A	anon	Bateman A	Family	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial and phage surface proteins such as intimins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.64	0.72	-4.09	46	5992	2012-10-03 16:25:20	2003-04-07 12:59:11	13	651	1569	19	1313	5130	392	78.80	23	17.92	CHANGED	sssplslsss......ssuhh.utshphsssth.ssuss......tphoWpS.sNsplAoVs..........ssGhV...ouhs..pGsssIsssssc..spssshTl	............................................................................tlpls.s.........phsl..h..h.G.....t.s.....h.p.l.s..s..s..h.....t...sssuss.............ppl.s....W....s....S.....u.....s.....s.s.l.A...oVs...............tsG.tV...........s.uls.....tG...s.....s.s..Is..s...s.s.ss...s..sh..........................................	0	641	1057	1180
+1372	PF04775	Bile_Hydr_Trans		Acyl-CoA thioester hydrolase/BAAT N-terminal region	Kerrison ND	anon	Pfam-B_2191 (release 7.6)	Family	This family consists of the amino termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT) [1].  This region is not thought to contain the active site of either enzyme.  Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have distinct functions in lipid metabolism [2].  For example, in peroxisomes, the hydrolase acts on bile-CoA esters [1].	21.30	21.30	22.50	22.40	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.52	0.71	-4.42	37	429	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	155	4	254	436	2	126.40	34	30.24	CHANGED	hD-.lpItlsGLsPsp.VTlpuphp..c...........-.....pGthapShAtapAsppGpVDLscsssl.uGoYpGl-sMGLhWShcP...p+hshthhppsl......h.pshhlplpshssp............lupsphcRhahusGVpRh.VcEs	.......hDEslpItlpGLsPtp..VTlcuphp..c................-..pG.s.hapupAtYpADppG.plD..Ls+ssul...GGoYsGl-PMGLhWohcP........p+sh.h...+..hh+psV..........sPh.hVplplhsup................thlupsshcRha.huPGVpRhsV+-..................................	0	37	72	171
+1373	PF03496	ADPrib_exo_Tox	Binary_toxA;	ADP-ribosyltransferase exoenzyme	Griffiths-Jones SR	anon	PRINTS	Family	This is a family of bacterial and viral bi-glutamic acid ADP-ribosyltransferases, where, in Swiss:Q93Q17, E403 is the catalytic residue and E401 contributes to the transfer of ADP-ribose to the target protein. In clostridial species it is actin that is being ADP-ribosylated; this result is lethal and dermonecrotic in infected mammals.	23.40	21.90	23.50	22.10	23.30	21.80	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.33	0.71	-5.09	26	558	2012-10-01 23:25:29	2003-04-07 12:59:11	9	24	360	74	64	557	16	184.60	17	40.09	CHANGED	AcpWGpcthcpatpp........................ossE+pAlptYTptsYpcINshL..Rpspsph.th...splpcp...........lcpl-uAhpKs.slPcsIhVYRtss.t.ht...t......................ppthpthpshhhu+hhp-tuYhSTSLsps.........uuFutp...l.h+lplsKGopuuYlss..l...............................Ssa.ssEhElLls+uspacl..........schsh.......sssppclll-Ahhltp	...............................................................................................................................................................sttch.tu....lt....Y.s........s......t..s..............h........t...tlN......phL......Rt..sp...............th......ppl.pp........................l...p.p.l...ssuhp..+....h.....h....p......s..h....h.l....Y.Ru........................................................p.thp.hh.p.th.h.....G.p.hhp.p.pu.ahS..TS..hstt......................................ts..hstp..........hh.h...clp.l.s.p.G.p...p.......u....h.h.lss........l............................................................o...th..ssEtElLls+ssph+l...............ppht.........................ht..............................................................	0	25	39	48
+1374	PF03495	Binary_toxB		Clostridial binary toxin B/anthrax toxin PA	Griffiths-Jones SR	anon	PRINTS	Family	The N-terminal region of this family contains a  calcium-binding motif that may be an EF-hand.	19.70	19.70	19.80	19.90	17.80	19.60	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.50	0.70	-5.85	8	100	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	61	59	4	126	0	353.70	41	51.40	CHANGED	s.sDTDsDuIPDsWEhNGYTl..pNKlAV..tWDDshAp.pGYpKYhSsPhcupTsGDPYoDaEKsuGcIDpuluhEARcPLVAAaPsVsVsMEKlILSKNEclSsppst........olSsuTSoSpTasNT.GAslsAuhuhhs.....hShuVSANYSHo.psTVus-aosSp........oaupohulNTA-uAYLNANVRYhNsGTAPIYcVpPTTohVL.csp...TlATIKAK-NphApsIsPsppYPpKupsuIALNTMDDFNS+PIslNYsQLcp.LpssKslpL-TsQssGsYuphs.osGplhlss..sWusllspIpupTASIIlssustss.E+RVAA+-.sNPEDKT.PcLTLKEALKlAa..uhpE.csGlLaY...Ns......KsIsEs.slphhlD-pTuppl+cQLpshss.....KslY....clKLpsKMNIhI+ssohhhs	..................DpDsDuIPDshEhNGYTl......psphAh.....tW-sphtc.pG.......hpKYlSsPhcusTsuDPYTDaEK.soG.phDpsss.pshsPlVAAaP.ltVshE+lllSpscshosppst........olS+s..oosS..po..p..os......ssGssspssh..p.h.s........huhuVSssaSpo.ppTss.pcS.up........sWupshslNoucuAhlNsNlRYhNsGTAshYpVpPTTslVL....ssp...oluTIKA..ppsp.h.up.LuPsptYPp+shsslulsohDpFuSp.IslNhsQLcp.l-ps.c.lpL-TsQspG.hshhs.psG.plhsts..pWuthhspIpthoAplhhsht.s.sh..chRlsAhs.psP.-pT.PphTlt-Alphua..thpc..ss.h.a...ps......h.I.c.....h.hDppTspphcppLtphts.....pplh....phhlp.tMNhhl+..............................................................................................................	2	1	2	2
+1375	PF02084	Bindin		Bindin	Mian N, Bateman A	anon	IPR000775	Family	\N	21.70	21.70	24.20	21.70	20.30	21.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.88	0.70	-4.31	10	599	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	43	0	2	613	0	138.30	52	94.71	CHANGED	YGNt...NYPQhhsPphGGsNYs.......GQ.sQQGYuspGM........GGPVGGG...s.uss.sssGt.uGslsGGG....huP.....h.spu.tss.uphc-YSSsshp-s...........-TTISAcVM-cIKAVLGATKIDLPVDINDPYDLGLLLRHLRHHSNLLANIGDPEVREQVLSAMQEEEEEEEpDAANGVR-NVLNNlN..NuPGsGGaGGstu...............uGtsGGh...sshG..sQGtGGshth.Ghssp...usuYN...QGYRQG	...............................s.......thsQ.hs..MGGuNY..............GQ.sQQ.....GYussGM...............uGPVGGG.......AMA.t.Ph...........G.G.GGAMAt...P..VGGGu............................uGPst..........h.G.....t.h....................ts.p-YSSs.....t...........tthIss.......................................................................................................................................................................................................................................	0	2	2	2
+1376	PF00351	Biopterin_H	biopterin_H; 	Biopterin-dependent aromatic amino acid hydroxylase	Finn RD	anon	Prosite	Domain	This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.	22.00	22.00	24.60	24.60	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.06	0.70	-5.68	6	1616	2009-01-15 18:05:59	2003-04-07 12:59:11	16	13	829	37	525	1403	197	213.20	33	70.19	CHANGED	PWFPR+IsELD+CsphlhpYss-LDhDHPGFsDpVYRpRRK.hA-IAasYKHGDPIP+VEYTcEEhcTWtpVFpTLpsLYPTHAC+EYhcsFsLLp+aCGa+EDNIPQLEDVSpFL+-pTGFpLRPVAGLLSuRDFLAuLAFRVFpCTQYIRHuSsPMaTPEPDsCHELLGHVPLLAD.oFAQFSQEIGLASLGAoDEtIEKLuTlYWFTVEFGLCKQsGplKAYGAGLLSSYGELhHuLS-+Pcl+sF-P-sTAVQsYpsppaQPlYaVuESFpDAK-KhRpaAuoIpRPFuV+YsPYTpuIEVLDSsppIpphh-slpsElphLssALsK	................................................................................................................................pYo.t-.tsWt..lhp.p.................thh.thAs.ttahpsh..l.....h..cplPplt.-lsphLt..............tto...G..a.plhs..ls.uhls.ttFht..hLA...+.hF......sspal.Rp.pp...Yh.E.....P..DhhH-lh....GHsPhl.....h..s.....s.........a..A...p.....a.p........t...h..G............hu.....h.t.s.........s...........t................t...h.t...........h...........L.u...p.......h.......aWa..TVEFGL.h.........p....p............t.......t.........h+hY..GuGlLSS..uE.....................a.s...h.......o.......s..t........s..ph.h.s.ap...sh.h.p.a.hs.hQ.hYal.ps....h....t...............................................................................................................................................	0	167	254	398
+1377	PF00364	Biotin_lipoyl	biotin_req_enzy; biotin_lipoyl; 	Biotin-requiring enzyme	Finn RD	anon	Prosite	Domain	This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognise the Glycine cleavage system H proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.22	0.72	-4.34	49	25099	2012-10-02 20:27:15	2003-04-07 12:59:11	17	167	4936	74	7239	20327	9244	71.80	30	15.82	CHANGED	tplpsP.hGphhp......thhVcsG-pVptspslshlEu.Khph-lsust.sGslpplhsptGss.VpsGphlhpl	....................................h..ltsP.l..Gps..h.p.........s....l....hphhVpsGDpV.........pt.sps.L......h.hl...E.u.......................K.....h.....p...h.....-......l.......A..s...........t.....s...G...........s.........l.p...c...l.h.....l..p.....p..G.ss..Vp.sGphlhh..............................	0	2248	4430	6064
+1378	PF03744	BioW		6-carboxyhexanoate--CoA ligase	Bateman A	anon	COG1424	Family	This family contains the enzyme 6-carboxyhexanoate--CoA ligase EC:6.2.1.14. This enzyme is involved in the first step of biotin synthesis, where it converts pimelate into pimeloyl-CoA [1]. The enzyme requires magnesium as a cofactor and forms a homodimer [1].	25.00	25.00	30.50	30.40	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.48	0.70	-4.94	17	405	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	395	0	39	195	3	228.90	45	69.10	CHANGED	aSl+MRAS......psspHISGAEcls.stpclcphlsphlp+uhsHpp...G.psDFlslplEclp.csIphlp.sLslcohpstshEcu+phApplLppt............GlscphhcpAh.chlscs......shRGAhllshcoGpRL-s.ctpRGVRVophDhs-pp....p.tlhpps...spRsh-AlAlAoKVhst.GVlAELChSDDssYTTGYVAscphGYhRIsslKptGs..GGRlFFlcsshcl.p..shIphLEppP..VlIp	......YSl+MRuS......................spshHISGAEols...p.hccIEQTVpphhp+uhhHpp...G.psDFlsl.+lpclh.psIppI..AL.l...................hc-s+t.hpcLh....p.c.s............GVo.cpAlppuh.phlpst.....sshpGAllLsAhoG+RLD....u..spRGlRsT+Fu..hpshss...........ps....hs...cRhp-ALslASplsAtPhVhuELClSDD.sYTTGYhAssclGYpRlhslKssso.hGGRlIFVD.s.s.h.....sl..s...phIoaLEspP......t.....	0	13	23	34
+1379	PF02632	BioY		BioY family	Mian N, Bateman A	anon	COG1268	Family	A number of bacterial genes are involved in bioconversion of pimelate into dethiobiotin [1]. BioY is a component of the BioMNY transport system involved in biotin uptake in prokaryotes [3].	23.10	23.10	23.10	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.91	0.71	-4.56	153	2666	2012-10-03 02:46:00	2003-04-07 12:59:11	9	7	2228	0	579	1839	1577	149.40	30	79.42	CHANGED	l.Ph....ss..VPlThQshuVhLuGslLGs+hGsluhllYLllGslGLPVFuGG..p.G.G.luhhhGPTuGYLlGahhuAhlhGhls.......c+hthp.................hhhhhhshlsGhlll.YshGhhaL..s.....hht..........t...lshsp....Alh.....huh.hsFlsGDllKsslAshlsht....l.pchh	.........................sh.ss..VP..lTLQshulh..LsGhlLGs+hGslohhlYlllG.sl.....G.L...PVFuGG.......p...u...G.l.....usl.h..G.P.TuGYLlualls.Ahl.sGhlt.....cphtpt......................................h.hhhh.h.s.h.l.hG.hhll.al.h.Ghhhl..t...........hht....................s......hshtp......Alhhuh.hsF.l.ssDl.l.K.slluuhluhtlh..h.......................................	0	205	400	503
+1380	PF00653	BIR		Inhibitor of Apoptosis domain	Bateman A	anon	Prosite	Domain	BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteristically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin (Swiss:O15392) [2].	22.90	22.90	23.00	22.90	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.81	0.72	-3.55	184	1889	2012-10-01 20:49:39	2003-04-07 12:59:11	16	35	348	189	901	1890	5	67.90	37	17.22	CHANGED	RlpoF.p.t.......................WP...hth...psp...p.LAcAGFaYsGt................sDpVpCahCphtl....psW.p.sD......sPhpcHt+atP....p.Ct...alp	...............................RlpTF.p..........................WP.......h..........s.s.s.cpLAcAGFaYsGt...................sDpVpCFhCsstL....p.sW.c.sD.......................cPhp-Ht.+ahP.....p..CtFl..........................	0	236	332	623
+1381	PF04197	Birna_RdRp		Birnavirus RNA dependent RNA polymerase (VP1)	Bateman A	anon	Pfam-B_2204 (release 7.3)	Family	Birnaviruses are dsRNA viruses. This family corresponds to the RNA dependent RNA polymerase. This protein is also known as VP1. All of the birnavirus VP1 proteins contain conserved RdRp motifs that reside in the catalytic "palm" domain of all classes of polymerases. However, the birnavirus RdRps lack the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RdRps [1].	25.00	25.00	33.30	30.80	17.20	17.10	hmmbuild  -o /dev/null HMM SEED	860	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.67	0.70	-6.51	5	338	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	26	27	0	228	0	401.50	68	97.83	CHANGED	MSDVFNSPQsRuoIosALGhKssuupDlc-lLlP+pasPPcDPlsus...pcAApaL+-NpY+lL+PRuIPE..Np.l-TDsh.hP+Lsph..l-...sGcLtDT..VSlPtGoocaIPKYYPsHKPo+pcsssa.PPDlTLLKQhoYpLLpss-so-Npt......-Tl+pLpcAIsTppYGSGShpGQlsRLlAMKEVATGR...NPNKoPKclGY.ThEclAchLDpTLPIsPPtsDDc.hlsLossLSaLl.hTsDsuss...cDYLP+IThKSSAGLPalGKTKGETssp.ALsluDpFLR-VSphLK-GAsTuuss.........................cpcLc+lLsDYWYLSCGLLFPKuERY-pscWLTKTRNIWSAPaPTHLLLSsISsPlMcsShNNlhNs.cTPSLYKFNPF+GGM-sIVshI...Lus.sEslhLVYADNIYIhh-N.....TWYSIDLEKGEANCTP-HAQAsuYYLLTRGWTs--GoPtFNsTWAThAMplAPuMVVDSSCLLMNLQlKTYGQGSGNAWTFLNNHLLSTIVVsKWscsGpP...................NPsSKEFtcLEutTGINFKIERsIcsLRpKLpEAscpAspsGYL.S-GoE.PPcpPuPTVELDLLGWSATYS+ah-hFVPVLDKERLasSAAYPKGlENKsLcuKsG...AEQAYKlVRYEALRhVGGWNYPLIspAscssAps+Rs+....LcsKGhsLDchlu-..Wsc..h.SEFGEslEslol..ccsVTspsLt-LNtsscshcPsVs+shsRs...sL+cVoNALppGsYKsspossGchLsstA+SRI.....ps.h...+scslt-pls+LKPscscuDsWs-RsEptustlctLh+AsslhcppLcEsucALEsVQ......SscllsuKpPpEKssppAoNPVVGY+..uc+h...........sShP...p..sLoPsu+KttKRRpKQ+cp	..................................................................................Pp....EhEsDQI.LPD.....LAWMR..QIE....GAVLKPT.....LSLPIGDQEYFPKYYPTHRPSKEKPNAY.PPDIALLKQMIYLFLQVPEAs-sLK...................DEVTLLTQNIRDKAYGSGTYMGQATRLVAMKEVATGR...NPNKDPLKLGY.TFESIAQLLDITLPVGPPGEDDKPWVPLTRVPSRMLshTGDsss-........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1382	PF01766	Birna_VP2		Birnavirus VP2 protein	Bateman A	anon	Pfam-B_946 (release 4.2)	Family	VP2 is the major structural protein of birnaviruses [2]. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].	19.70	19.70	21.60	21.10	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.32	0.70	-5.56	4	2317	2012-10-04 01:49:40	2003-04-07 12:59:11	12	5	39	48	0	1558	7	234.70	75	85.90	CHANGED	ppspspYL+SLLhPpsGsuSIPDDhhtRHsL+sEToTYNLpsusoGSGLIVhFPssPuSllGAHYphsuss.shhFDQhlhTuQ-LKcuYNYuRLlSRplsV+SSTLPAGVYALNGThNAVTFpGSLSElpDhSYNuLhShTuN.pDKVGNVLVG-GVsVLSLPsGaDhPYVRLGDcsPth.pSs.thsspCssuspPRtYpIssss.......V.ssGspsphauhNlDulsssslss-hphphpsps.hshshpsh.luhsGhssssRslohossshusTspa......hstlhspspITpPlsulKlphph....u.tsusshu.sssSSluloltGGNhPGsLRPlTlVAYEpVAsGSllTluGlSNYELIPNPELtKNlsTpYG+hDPtshsYsKhILScR-cLGlRoVWsht-Yp-hppYFpEloDhsSsL+hAuAFGatDll+uIR	...........................................................................................................................................................................................................................apIshusph......s.YQsGGV...TITLF.SANIDAITSLSlG.GELV.FQT....SV.Qu...LlLGATIYLIGFDG..TAVITRA....VAAsNGLTAGTDNL....MPFNlVI....PTsEITQPITSIKLEIVTS...........KSGGQAGDQMSWSAS.GSLAVTIH..GGNYP.GALRPVTLVAY.................................................................................................................	0	0	0	0
+1383	PF01767	Birna_VP3		Birnavirus VP3 protein	Bateman A	anon	Pfam-B_946 (release 4.2)	Family	VP3 is a minor structural component of the virus. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].	20.80	20.80	29.10	28.50	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.65	0.70	-4.75	5	161	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	30	2	0	176	0	219.30	65	23.46	CHANGED	lcYLs.......cLtMsosuSutcPELEcslcAhMAcA+clPsup..................KlLsLhSWsRcNuLlDcMacWAp.........pDPcAlRhcRhLuNsP+cGpKspctKhhsts....uKGPTpcs.......AQ-AKAsRISpDAscsGt-FATPEWVA..pNsaRGPoPGQhKYYhtTGhsP-PG--YpDYl+psloRPss-sKItRLAsSlYGhPsQEPAP--FhDtVAcVas-NsGRGPsQ-QM+DLRctARcMK+R	.....................L.PYLPPsAGRQ..acLAMAASEFKETPELESAVRAMEAAAsVDPLFQ..................SALsVhhWLcc...N..GllscMssFuh.........oDPsAcRhcshLussPptupK........ts....s+GPT.cc.......AQ+tKsTRIStch.shGh.FATPEWVA..LNGaRGPSPGQhKYapsTtclPDPNE-Y.DYV+s.ppoRhss--pIhRhAsSlYGsPsQs.sPpsFlDcVAcVY-.NcGRGPsQEQM+DLh.tAhcMK+R.......................	0	0	0	0
+1384	PF01768	Birna_VP4		Birnavirus VP4 protein	Bateman A	anon	Pfam-B_946 (release 4.2)	Family	VP4 is a viral protease [1]. The large RNA segment of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [1].	21.20	21.20	21.20	22.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.62	0.70	-5.33	4	354	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	42	21	0	303	3	175.60	57	29.75	CHANGED	VAsPVlSTLFP.AAPLIGAADphlssLhtssAuuGRhsu+AAuG+h+ss.cphtsho.suphuhplcspL........EssNapcs-l.+s.........ppuslFPVVhTs...cssPu-s.uphhsVI.Gth.-L.sPNQpshshaphsstpVaGhupD..lPhEssc.sYTsLPlc-l.hsGsIslpK..hsPlhGsSuQLAI.hhssslcpGV....Ph.hsFTGplsts..olh.IpGVsl...KhhsAHcLGLPLlGspPGls-hsssTSLAs+lh	.............lAsPVlSTLFP.AAPLhtAhsphls.LhtspAtuuphpu+AAuG+h+ss.sphtpho....suchuhplhspL.........ss...htpstl..s.................lhPVlh.............................................................................................................................................................................................................	0	0	0	0
+1385	PF03042	Birna_VP5		Birnavirus VP5 protein	Bateman A	anon	Pfam-B_1772 (release 6.4)	Family	Birnaviruses are ds RNA viruses. Non structural protein VP5 is found in RNA segment A. The function of this small viral protein is unknown. The proteins are about 150 amino acids long and contain several conserved histidines and cysteines that might form a zinc binding site (Bateman A pers. obs.).	25.00	25.00	33.40	39.90	19.50	18.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.73	0.71	-4.66	7	113	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	16	0	0	102	0	123.50	64	94.44	CHANGED	hpDEHppuNRNLhElHYASRDWss+...HSGRHNtEsHsKTRDLVlQh..RGhRlRKhsSCLhPWtohlpstCoLQsEsEPDGstlRPVAsDlsGPcEulQLhEAslpEIR+scLHsstWsLCochD.cRpcLRRpSl	.sDc.s+uN.s.spVHstspDANsRTGVHSGRHPtEAHoQVRDLDLQhDCtGaRVR..AsCLFPWhPWLsCtCSLHs.AEQWEhpVRssAPDssEPstpLQLLQASEoEs+ppVKHTsWWp.LCTKhc+KRRDLPRKP..	0	0	0	0
+1386	PF03493	BK_channel_a		Calcium-activated BK potassium channel alpha subunit	Griffiths-Jones SR	anon	PRINTS	Family	\N	26.80	26.80	27.50	26.90	26.00	26.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.24	0.72	-4.06	35	665	2009-09-11 05:04:26	2003-04-07 12:59:11	13	15	154	10	289	608	6	99.50	40	9.24	CHANGED	shsphhhphs.-pllslpElKhsllApsslsPGhsTllsNLlpopp......phss.t..........ppWhspYhpGhtp-Iaphtl.sspF....hGhoFsplsthhacphsllLlGlE	..................................................s..spaphK.u..DcslChsEhKhuh..............lAps.C.l.sPGhSThlssLhphpp..........h.ch.pp..............................................-pW.p+hYhcusu.NEhYs.hL..sSsF.................hGhSFstss.hsatKh..t..lhLIulc.........................................	0	105	144	218
+1387	PF04940	BLUF		Sensors of blue-light using FAD	Yeats C	anon	Gomelsky M, Klug G	Domain	The BLUF domain has been shown to bind FAD in the AppA protein (Swiss:Q53119). AppA is  involved in the repression of photosynthesis genes in response to blue-light.	25.00	25.00	27.00	26.20	23.40	23.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.76	0.72	-4.26	154	831	2009-01-15 18:05:59	2003-04-07 12:59:11	7	19	584	55	218	692	223	91.60	38	33.13	CHANGED	LhpLlY..hS.........ps.p.shs......tppltsIlppupppNtptslTGhLla......s..sshFhQhLEGscpsVppla.p+IppDsRHpslthlttp.l.spRtFss.WsMsh	.............................LhpLlY..tS.........ch..pss.hs.......spclppllshApppNhpsslTGlLla........s..sspFhQlLEGs.c-pVptla.cpIppDsRHtsls.Lh.p.c...h...stRpFuc.huMt.h..........	0	55	135	179
+1388	PF02608	Bmp		Basic membrane protein	Bashton M, Bateman A	anon	COG1744	Family	This is a family of basic membrane lipoproteins form Borrelia and various putative lipoproteins form other bacteria.  All of these proteins are  outer membrane proteins and are thus antigenic in nature when possessed by the pathogenic members of the family.  One protein Swiss:032436 is a transcriptional activator [2].	20.80	20.80	20.80	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.58	0.70	-5.68	13	3407	2012-10-02 13:57:41	2003-04-07 12:59:11	9	10	1918	5	933	2720	1656	294.70	25	81.15	CHANGED	hhhlulhssGslsDKuFsppua-Glp+hpcch..slchhhtsust...............sshhsshpplpcpshDLIhssGaths-slptlusch..........PchpFhllDuhhpp-...............NlsolsFRspEuuFLsGhhAAhho+psphualu....................GhphshhpsFhhG.FctGs+YsN.....clclhsphssoasDsstupshApphhp.cGlcVIas..huGhsshGVhpsA+-hG.p......hsIGhDpDQ.....uahuscsllsSslpslschhhphhpphhpss..h.sGpshphGL+cusVGhs................c..chh.schhcchlphtpKhl.ttl.lsspc	.............................................................................................................h...shlhssG.slsDpSFNpus.h.p.G...hp..th...tcc....h........s......l...c....h..t....h..h.p.shs.....................................................t.s.-.h..t.s..s.l.p.p.h.....s.p....s.....u.h.....slIh..u.s.Gatht......s.s.l......t......p...s......Apca.............Pc..h.p.F..s..l.l...D....s...h...hp.sp............................Nlsohsa.pppE.uuYL.uG....hhAu..........h.....h.o.....K........o........s.......p.....l.....G.....a..lG...................................................G....h..p..h..s..h.l..pcF....sG..F....t....t.Gs....c....ss....s.........................ssl..p........l........t......s.......p.......a.............s......s...............s.......a...............s.....D......s....s....K....u..cphA.p..u.hhs...pGs......D..llap.........suG.ss.G.sGl...h.ps.A.cp.t.sth.......................................sIG.VDp.DQ..................s.t.h...s.....s.....p....s......l.....l.s..S.s.l.c....p.h.ss.shhphs.pp....hh....c...u....p...................t.......u.......p....h......h....h...h...GL.c-.s..u...V.s.ls.........................................p...h.s..t...p..h...h...p.t...h.......p.......t..............t..................................................................................................................................	0	342	623	769
+1389	PF01722	BolA		BolA-like protein	Bashton M, Bateman A	anon	Pfam-B_1996 (release 4.1)	Family	This family consist of the morphoprotein BolA from E. coli and its various homologues. In E. coli over expression of this protein causes round morphology and may be involved in  switching the cell between elongation and septation systems during  cell division [1]. The expression of BolA is growth rate regulated and is induced during the transition into the the stationary phase [1]. BolA is also induced by stress during early stages of  growth [1] and may have a general role in stress response.  It has also been suggested that BolA can induce the transcription of penicillin binding proteins 6 and 5 [2,1].	25.70	25.70	25.70	25.80	25.60	25.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.54	0.72	-4.02	238	4233	2009-01-15 18:05:59	2003-04-07 12:59:11	13	22	2088	10	1342	2705	2605	73.30	33	73.74	CHANGED	p.Lppsl.ssp.p.lpVps.S...............................tsHFclhlVSstF.pGhshlpRH+hVassLt-.cl..sss....lHALul.+.shT.PpEa	................................................h.lppuh.sst.p.lcV...ps.u..........................tG..toHFplhlVSctF.pG.h.shlp+HphVYssLt-pl..sss....lHAL.u.l.+.shTPpEa..............	0	378	743	1064
+1390	PF02044	Bombesin		Bombesin-like peptide	Mian N, Bateman A	anon	IPR000874	Family	\N	18.10	18.10	19.60	18.40	16.80	16.60	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.87	0.72	-5.80	0.72	-4.41	12	105	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	53	2	39	125	0	13.20	79	12.60	CHANGED	GspWAVGHhMGKKS	.GNpWAlGHhMGKKS	0	2	5	9
+1391	PF02414	Borrelia_orfA		Borrelia ORF-A	Bateman A	anon	Pfam-B_1805 (release 5.4)	Family	This protein is encoded by an open reading frame in plasmid borne DNA repeats of Borrelia species. This protein is known as ORF-A [1]. The function of this putative protein is unknown.	19.60	19.60	20.70	20.50	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.19	0.70	-5.30	25	681	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	33	0	37	578	2	235.80	31	82.34	CHANGED	KhQaK...LIsLISTLpYlNpphKK.....................YoQpsILYaFNpNLKRNGQ+slplKTLQpYLY+L-K.hpVTp...NYa+HLG.lNh...GTEIYYKLpasKcc.CaphIN.pYFc-+Kcp+apsRl..........sshh..pcchsKpssVpht....................................................EChsNps.s..NK...cEc..pKptc..IEchplpKYhpKCNFhsp.........llpLplpK-tpIclhKhhK+hE.tlhK..................................p.hph.c...pphKsKpppLKpILpNh+..hphcpcsYspcQLcpphpchYc.pYKsKPHFIIEppKYs..DLspI.htKlKcshcpp.Kpsspcshp.pIKsNI.........aN	................ph.hK...ll.lhusl.alNpph.....cc.....................YsQpsILhhhNpNLp+ss.p.ssl+Thpp.LhhLp+hhtlp....sahpphG.hsp....Go..h.aYclph.h........p.s......aphIs.paFpppctphhpphh.........................pt.h......ppph....p.t.s.lp...........................................................................................................................................................................................................psh.spp......sh..hpp...+.....h.p....p.p...........p...h..tp.sh...................ppt.h..hphhp..p...c.tlh+.............................................h.....phpp.pppph+phL.shp..hph.pptYp.cpl...h.p.hp..YK.K.ahhhcptchp..Dh..l.htchccpht.p...Kpp..pps.p..php..h.........................	1	29	29	29
+1392	PF03183	Borrelia_rep		Borrelia repeat protein	Mifsud W	anon	Pfam-B_2029 (release 6.5)	Repeat	\N	20.60	20.60	23.00	20.90	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.02	0.73	-6.24	0.73	-3.84	14	96	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	5	0	0	96	0	18.00	64	43.37	CHANGED	TlSILlS+SLhoDhp.h.	TlSILLSRSLhSDFsShh....	0	0	0	0
+1393	PF00228	Bowman-Birk_leg		Bowman-Birk serine protease inhibitor family	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	22.20	20.80	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-7.35	0.72	-4.08	55	570	2009-01-15 18:05:59	2003-04-07 12:59:11	15	4	80	50	85	586	0	25.90	43	37.76	CHANGED	sCcsChCoc.....ShPPpCpCtDhhpt.Ch	.sCcpC.h.CTc.....ShPPpCpCsDht.t.Ca....	0	0	20	52
+1394	PF02653	BPD_transp_2		Branched-chain amino acid transport system / permease component	Bashton M, Bateman A	anon	COG0559 & Pfam-B_654 (Release 7.5)	Family	This is a large family mainly comprising high-affinity branched-chain amino acid transporter proteins such as E. coli LivH Swiss:P08340 and LivM  Swiss:P22729 both of which are form the LIV-I transport system [3]. Also found with in this family are proteins from the galactose transport system permease [2] and a ribose transport system [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.59	0.70	-5.43	51	33622	2012-10-02 17:14:55	2003-04-07 12:59:11	11	38	3614	0	9346	25680	15397	275.60	20	80.62	CHANGED	tlhshlthus.lslhuluhslsh.hsGhhsluhuuhhshu.uhssshhhthhs.......................................hhlullhuhlsusshGhlsuhlhhthplspl.........lsolh..................hhhhhhulshhhhtthhts.tsss.....h.sshhsh.sshhh.hshthhh..........................................................................lhhllhsllhhhllt+TphGhtlpAlGps......puAchsGlslp+hphhsasloGhhAuluGhlhshhhsss........shuhs....hthtslsssllGGs........ssshGslluullluhlps.shshhth.....................sthttllhGhlllhsl	.....................................................................................................h...shltt.ssh.h.sll..A...l..G..h..s..l..l......h..h.......s.......G.......h.......l.....s.......luhu.u.hh.slu...u...h..s....s..s...h.h...h..t..t.h.s.....................................................................................hhl.u.l..l.....h.u..h....l....s..u....s........l..h.....G.....h.....l....h.....G.....h.....h.....h.....h.....+.......h......p.......h.....s...........h.................l..s...o..l..h.............................................................h..h..h...h...h....h.....s...l....s.....h..................h......h.........t......t......h...h....s....s....s.....t....s.....s...................h.h.t...s...h....h....t.....h......h....h...h.....h.....h....s.....h..h.......h.hh....................................................................................................................................hl..h..l....l....l...s...h...h..h...h...h.....h....l....p....+....T...p...hG..pt...lhA..lu....ps......pu.A.chhG.lss.p+hphhsasluuh.lAul...A..G.s..l.h..u.t....t..h.s.s.sss..........shu..h.s.........h.t.l..p..u..lss...sl.......lGGh..................Gsl.h.G.s....l..l..G.u....l....l....l..u....h.....l....p.s......s...h...s..h.hsh........................................s...................s.hp.....l...l.h.uhlllhh.........................................................................................	0	2466	5546	7467
+1395	PF00634	BRCA2	BRCA2_repeat;	BRCA2 repeat	Bateman A	anon	Prosite	Family	The alignment covers only the most conserved region of the repeat.	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.08	0.72	-4.65	25	1602	2009-01-15 18:05:59	2003-04-07 12:59:11	13	37	218	1	293	1604	4	33.50	36	11.38	CHANGED	hcsshsuFpTASGKplsVScpoLpKu+plhs-hct	...........s.hhuFpTASG.K.plp.VScpuLpKu+pl..Fp-hp.............	0	99	128	183
+1396	PF02498	Bro-N	BRO; 	BRO family, N-terminal domain	Mian N, Bateman A	anon	Pfam-B_1235 (release 5.4)	Family	This family includes the N-terminus of baculovirus BRO and ALI motif proteins. The function of BRO proteins is unknown.  It has been suggested that BRO-A and BRO-C are DNA binding proteins that influence host DNA replication and/or transcription [1]. This Pfam domain does not include the characteristic invariant alanine, leucine, isoleucine motif of the ALI proteins [2].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.92	0.72	-3.70	257	2580	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	1532	0	314	2002	73	91.30	24	37.17	CHANGED	pl+slh......psschWasup-ls.psL..sa........sss.p........csh......hpcl.cc............ptp..h..................................st........................h............hhlscsGlapLlhpS......c........hs.....p..AcpFppWlh...p-llP	......................................lRhlh....ssc..a.FsupDls.phL....sa....................sss..t...............csl......tppl.cp...............cpp.tth.....tp...........p..............s.ut....t.........................................................pp..h...............hhlsEsGlYpLl.h.pu..c...............hs...............p..AcpFppWlh....ppllP............................................................	0	99	222	272
+1397	PF03032	Brevenin		Brevenin/esculentin/gaegurin/rugosin family	Griffiths-Jones SR	anon	Pfam-B_1232 (release 6.4)	Family	This family contains a number of defence peptides secreted from the skin of amphibians, including the opiate-like dermorphins and deltorphins, and the antimicrobial  dermoseptins and temporins. The alignment for this family includes the signal peptide.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.63	0.72	-4.12	19	1689	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	76	0	1	1661	2	43.60	54	62.46	CHANGED	shLKKSLhLlLFLGhVSLSlCEEEKc.-sE...sc-cpct-cpp...Eh+R	...........FThKKSLLLLFFLGT.ISLS.LC.E..c...ERs.AD.EE-..tc-tpp.c..........c........................................	0	0	0	1
+1398	PF01318	Bromo_coat	Bromo_CP; 	Bromovirus coat protein	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	25.50	245.80	20.40	24.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.01	0.71	-4.59	3	16	2012-10-04 01:49:40	2003-04-07 12:59:11	13	1	6	39	0	19	0	188.60	71	99.28	CHANGED	STSGTGK.LTRAQRRAAAR+N.RhT+cVQPVIVEPLASGQGKAIKAhTGYSVSKWsASssAlcAKsTsAlSIoLPcELSSE+NKpLKVGRVLLWLGLLPSVAGTVKuCVTEKQsoAAASFQVALAVADSSKEVVAAMYsDAFKGlTLGDLpsDLoIYLYSSAALsAsuVlVHLEVEHVRPTFDDpFTPVY	.STsGTGK.hTRAQRRAAAR+N...R..pTphV...QPVIVEPlASGQGKAIKAhsGYSlSKWpASssAhp.AKsTsAloIoLPsELSSE+NKpLKVGRVLLWLGLLPSVuGpVKuCVTEpQssAuAuFQVALAVADsSK-VVAAMYs-AFKGlTLtpLhscLpIYLYSStAlsAtsVlVHLEVEHVRPTFDDhFTPVY..	0	0	0	0
+1399	PF01573	Bromo_MP		Bromovirus movement protein	Bateman A	anon	Pfam-B_508 (release 4.1)	Family	\N	25.00	25.00	26.20	26.60	17.80	17.30	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.50	0.70	-5.42	16	150	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	28	0	0	151	0	263.30	43	94.53	CHANGED	ssppulol...otc-.ppL.cplscshpsshtpshsh+tCsshthp.Nssuhpsh-LsoK-s+uhlo..+hssKl+pplhVcHshIaLlYlPhILpoTsussslKLhNhATG-chslGsphsLNcAFIlthsWPRSlhscss.pt+GLaLshpss.Assl.ssutlGphhPhW--sho.tK.hYpcsss.hshsht-s.ss+.lhocKhhpSLlpSphptshsuppcts.hlps.plp..cph....cFTlpphp.ssss...........tspstppstlsstpshh-pshsss	..................P.SoSsFSV...Sh.D-hspluc-lcclh.usphpslsTKtCahLpLl.NhstsssLcLsSKEpKuFLo..R.uDKVKp+lYhshutlaLlYlPlI.s..TTSGllTLKLpNssTGEhsDVsTDV-AN+AFllhsRWsRSLhtsA.....-LsLlholS..sscV+ssA+VGchhsFWDE+hS.+pQhY.-cuNslhFPItETcss+hlsscKlLhShVRSRlhsGspupc.hs.spslpscRlussc+s.....hTlp.tsshsc-............hcstspshsusscshhE-thh...................................	0	0	0	0
+1400	PF04450	BSP		Peptidase of plants and bacteria	Finn RD	anon	Pfam-B_5066 (release 7.5)	Family	These basic secretory proteins (BSPs) are believed to be part of the plants defence mechanism against pathogens [1]. 	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.54	0.71	-4.86	24	266	2012-10-03 04:41:15	2003-04-07 12:59:11	7	11	162	0	155	275	4	193.70	30	72.57	CHANGED	tsslphclps..s.sosGupp.......................Ftphl...s.uppsLssAsphlhphh.ps..ss-+......................ss..csVTl......hlcDh-GVAhooG.....................ppI+hSspYltshss..scs+....tElsGVLhHElsHsaQass..............ps.pssuGLIEGIADaVRL+AGhsss+WtpPusG.........scWD.pGYphTAhFL-ah-s..hs.GFVuclNcch.+ssY...........s-saahplh.Gcs..VppLWp-Y	.........................................................h...h.hp.ps....pp.u.uthF.p.l......stphltpu.hthlhphh.ps..stsp...........................ss..ppVsh..............hl.c.s....h..sG.VAassG.....................ppIahSspaltphs.......sphp........tEltGVLhHEhs.Hs...aQass................................ps..psPuuLIEGIADaVRL.c...u.u..h..s..s..s..p.....Wt.p..ss..tu..................ppW-.pGYphTAhFLsalcs.....ht.uhVtplNcph....csta....................................pcshahplh.Gps.....lcpLWp-Y..................................................................................	0	33	107	133
+1402	PF00779	BTK		BTK motif	SMART	anon	Alignment kindly provided by SMART	Motif	Zinc-binding motif containing conserved cysteines and a histidine. Always found C-terminal to PH domains. The crystal structure [1] shows this motif packs against the PH domain. The PH+Btk module pair has been called the Tec homology (TH) region [3].	21.80	21.80	21.90	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.86	0.72	-4.33	26	515	2009-01-15 18:05:59	2003-04-07 12:59:11	14	28	86	12	259	461	0	31.70	38	4.63	CHANGED	ppYHPshah..sGcWhCCppss+sAsGCshssst	...............pYHPuhah..sG+WhCCpQs....s+sA.GCphhps.t.......	0	41	60	128
+1403	PF04514	BTV_NS2		Bluetongue virus non-structural protein NS2	Kerrison ND	anon	DOMO:DM04350;	Family	This family includes NS2 proteins from other members of the Orbivirus genus.  NS2 is a non-specific single-stranded RNA-binding protein that forms large homomultimers and accumulates in viral inclusion bodies of infected cells. Three RNA binding regions have been identified in Bluetongue virus serotype 17 (Swiss:P33473) at residues 2-11, 153-166 and 274-286 [1]. NS2 multimers also possess nucleotidyl phosphatase activity [2]. The precise function of NS2 is not known, but it may be involved in the transport and condensation of viral mRNAs [1].	25.00	25.00	83.80	37.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.37	0.70	-5.57	5	118	2009-09-11 00:56:28	2003-04-07 12:59:11	7	2	50	2	0	126	0	347.00	51	97.69	CHANGED	MEQ..KQRRFTKNVFVLDtppKTlCGpIAstsupPYCQIKIGRshAl+sVsTPEPKGYVLEIs-sGuYRIQDGsDIISLMISs-GVEuTTERWEEWKFEuloslPMAssVslNG.......spsDAEIKYsKGMGlVPPYTRNDFDRREhP-LPGVp+ScYDVRELRQKIREEREKusccpsppsuhKsE....RhhttscsD-DpsshsptAs-hsPcTp+p-pccERRcsltp+lt-t.p....hphp.-c+cc-h++cpcppcsscscSD-s.......D-cGEDS-...--EscscoYITpsYIERIu+l+KhKDERLSuLAStMPQsuGcassMIFoKKpKW-NVPLYsIDEsuK+YELQSVGuC-RVAFVSKGhSLIILPVuu	.................................................MEQ..KQR+FTKNlFVLDhstKTlCGtIA+tsSpPYCQIKIGRslAh+sVpsPEPKGYVLplsssGAYRIQDGpDlISLMlTspGVEuTpERWEEWKFEulSssPMATtVphNGshVDAEIKYsKGMGlV.PYhRN.D.F.DR.pEMP-LPGVh+S..sY...D...VRELRQKIKpEREuusch...p.pul....us+pE....sRWh......D-DEsplDEtup-hhP.tst+l-p.cEtRsslh+clttt.........hphs.pE+pct.+sEp-...cp-phps.SDc..........DEpsEDup...--E.cPcoaITcEYIE+luK.hKhK..DERh.SLuStMPQsuGsas+hIhoKKhKWpNVPLYsaDEuoK+YELQsVGuC-RVAFVSKDhSLIILPVG.V.................................................................................................................................................................................................................................	0	0	0	0
+1404	PF04426	Bul1_C		Bul1 C terminus	Kerrison ND	anon	DOMO:DM04045;	Family	This family contains the C terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524) [1].  The complex containing Bul1 and Rsp5 is involved in  intracellular trafficking of the general amino acid permease Gap1 [2], degradation of Rog1 in cooperation with Bul2 and GSK-3 [3], and  mitochondrial inheritance [4]. Bul1 may contain HEAT repeats.	24.20	24.20	24.20	24.70	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.71	0.70	-5.20	17	182	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	62	0	117	183	0	186.50	20	30.29	CHANGED	HDQENWhpLhphls-pE+psLpcLslpLoCIQSNNShsH.sPPcIpSlTTELlCITu+SDN.SIPIKLsuchLh.sc-Klssl+psFpsappplp-Ypp+FpcNhcKLN-LYNhs+sh..ssREL+FoDFIosQlhNDlESLuNLcVplpsLpplFKKQhpohcspsp......stssossshtsp..ttsp.......................s.tthhppplhppWhppss.pYcRpls..VNLphNp.cl+ET.........LVPoFESCLCCRFYslRVsIKF-pHlGo.splDlPVsV+ph	..........................................................................................................................s.t.....hptlpsphhshohpo.p..shPh.hp.thhh...tp............................h.............ht......................h.....h..ph..slpshtthp.p.........................................................................................................................................p..t....phpppht......lsl.p.h.tt.....p.s.................llPsFpoChhsRhYhl+lplch.t.p............s........s.......hplclPlplt..............................................	0	11	58	112
+1405	PF04425	Bul1_N		Bul1 N terminus	Kerrison ND	anon	DOMO:DM04045;	Family	This family contains the N terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524) [1].  The complex containing Bul1 and Rsp5 is involved in  intracellular trafficking of the general amino acid permease Gap1 [2], degradation of Rog1 in cooperation with Bul2 and GSK-3 [3], and  mitochondrial inheritance [4]. Bul1 may contain HEAT repeats.	28.70	28.70	29.00	28.70	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.50	0.70	-5.92	27	164	2012-10-02 22:29:00	2003-04-07 12:59:11	7	7	69	0	105	170	0	361.50	28	49.70	CHANGED	ssspshphss.spss....sps.lhDlLPSFcMY.solp++lspushs.Dh+shPPoYp-spsppss................sstsssshs.tp.sh.ssstp..sps.p............................p....p.sl.t.t..................................sht....Dshs..p.pshhlDplapLPKLo......o.Pl-lpI+lTKcsspP.pt.ps-.-ohLKEYosGDlIpGYslIpN+SspslpF-MFYVoLEGhhsll-+..........p+sKpplKRFL+MhDloASWoYsslshusGhp.....hhssphD.hDsshlGLsssRlLpPss+YKKFFhFKlPppLLDssCc.cphhsHsLlPPShGlD+hppts+hptIphNpsLGhGalsh+GoPlL...................TpDhu.-slSIsYol-ARllG+s..................pcsschsIhKEppY.LRlIPhsht........sshhsppsshp........hcslhchlpc+l..pthcclhpclcppcs.lss....-l+spsloush	........................................ttp.............t.ttp.l.slLPSapMa.pslhpph..s...sp...shp......PPsYt....pp.s.......................t.s.t....................t.t.........................................................................................................psht..t.pphhl-plhpLspls......s.slplpIhhT+phs..t......-s.lpEYppGDhlpGahhlpNpSspsl.F-MFhVshEuhhphhsp..............tt.hph++FLcMhDhsASW.s.spls..ss.p........hh...hD.hDsshhulsssRlLpPshpYK+FFsFKlPppLLDssCp.p..p......h......h......s......Hs.hLPPohGls+.hp..sphtthths..p...........................s.h.............................hpDhu.tshSlsYslpA+hlG+t...........................psschhlhcEtph.lRllPhsh.........t....t.ps.........hpsh.p.lpp+h......thhppl.pthp.t...................h..............................................................................................	0	10	51	98
+1406	PF03557	Bunya_G1		Bunyavirus glycoprotein G1	Bateman A	anon	Pfam-B_653 (release 7.0)	Family	Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G1 glycoprotein which is the viral attachment protein [2].	25.00	25.00	31.90	31.90	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	871	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.79	0.70	-13.63	0.70	-6.74	15	361	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	74	0	0	338	0	609.20	35	56.09	CHANGED	YsslAppLtuhstIS.LDhshlshlP--IuuAL+hIEsp+TYHp.lhlEhshLo+YCDYYopFscNSGYSQTsWRhaL+oHcF-lChhaPNpHFC.RClpcusKCssusWDFAsEMpsaYouKps+Fs+DLNLhLpsh+pAFRGTopualsphlpcKcssslhphhsKl+pKaPsNsLLhullcahpYLhuLschosacLsp.Wc-hlapspspppsphs+spcS..YpasNAtssssoKsCcNhKsVsCLSPRuusshsslIACG-sss.plYchPs.plYpSNscpspaClsDoHCLp-FEslspEhLsulKKopCWts-hsshs.cppSsGl+SC+hKDpGsCsVsss+.WsIIpC-sspaYYS-t+csaDpspDIG.HaCLSs+CsT.RYPINPcpIpsCsWphppsphcpIsshsLE-lEpYKKAIopKLpsoLoIa+Yp..TcNLPHIKPlYKYITlpGTETuEGIEuAYIpSpIPALuGTSIGFKIsSKDGppLhDlIsYVKSAsYposYsKlYsTGPTIGINTKHDE+CTGsCPspIsHKsGWLTFu+ERTSoWGCEEFGCLAIssGCVFGSCQDII+sEhsVYRKssEEssslElClTFscKTYCT-lNAlpPIITDchElQFKTV-ohoLPpIlAVpNHclhsGQINDLGsaSpGCGNVQKsNuTshGsGsPKFDYlCHhASRK-VIlRKCFsNsYQuCKhLpp.sShhh--cpsTlTVhchK+lLGslphKhILGDl+YKsFAEslDlpsEGpCsGClsCFEsIpCpFsIcoolEsoCslcusCThFHDRIlIoPsc+cYAlKlhCpcKPssolpFKICNpKl-sshTlVDtcshIELuslDQTuYI+EKD-RCKTWhCRVRDEG	...................................................................................p........hst...pht..t.hp.h.l.ppp....cshcsthhhEahhhthhs..shappa.psuG.sphpWRhhh+spphchC..assphhC.RCl.ptpcCsssphDhupphpphYptppphaptDlplhh..ht..h.t.s..hh....tptt......h..th..t......h..hh.hh.hh.............................................................................................................................................................................................................................................................................................................hsGhu.sa.lps+pupph.h-hlhYlKSsthphshschYsTuPh.uhsspa.phCTGsCs..s..pl.t..t..ssahsFshp.TS.WGCEEhGCLAIspGslhGpCpsl..hc...-..h..t.lYp..p...hppth.s-lClo...tt...shCs....plsshpPh.ss.....hphphp...s...spshslspllul.p.s.pclh.GpIsclGshs.p...h.GpsQh.s.p..s.....s..l.....h.....s...........us...s....c.FD...a....Cp...hhu+Kclhl+pCh.ssYpupphLpp.ssh.....hp.ppts.hhhphph.LGplphhh.Lsc.haK.h.s.p.p..pl.p.s.c.u.pCsGChtChpslpCphphhoshths.ssl...s.s.Cs.ap.s.pl..hlp.sppchslKhhCppp.t.ph.h.lsttp.pht.ph.h.tp.hl-...s..Dp...............................................................	0	0	0	0
+1407	PF03563	Bunya_G2		Bunyavirus glycoprotein G2	Bateman A	anon	Pfam-B_1048 (release 7.0)	Family	Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.  This family contains the G2 glycoprotein which interacts with the Pfam:PF03557 G1 glycoprotein [2].	25.00	25.00	30.20	25.60	23.70	18.80	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.98	0.70	-5.52	9	412	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	74	0	0	340	0	233.50	57	29.30	CHANGED	ssshsRCFtGGpLltphpSssuhoElClKDDIShlKSpsha..tKNcssIhussKhaRpahVpDWppCNPl.ssuGoh.Vl-VscshpLhsKsYsCpssCsIol-+-sApIlhposcLNHFElsGTTlpoGWFKsKsoloLDpTCEHl+VTCG+KolpFHACF+pHhSClRFh+poILPt.MhpShCQNIELIIlshhslhhhIhhlILTKTYIsYLLlPlFhPhsalYGhlYN+sCKpCpsCGLAhHPFTsCsopClCGh+apoo-ph+lHRputhCpGYKSLptAR	.....sslhpRCFpsGsllKppsSppuloElCLKDDVShIKopupY..hKNsoGlausNhshRpWlVpDW+-CpPhcssGGpINVIEVscDLoLpTcoYlCoADCoIslDKETAQlhLQT-shNHFEluGTTlKSGWFKoTshITLDpTCEHl+VoCG.KolpFHACFpQHhSClRah+tohLPt.hhpShCpNhElIllh.h.hh.hhhh.lloKTYlsYlhhPlFhPhshhYuh.h.+.hK.C..ChLshHPFo.Cs..ClCG..atso-th+hHR.sh.C.GaKsL.hsR.....	0	0	0	0
+1408	PF01104	Bunya_NS-S		Bunyavirus non-structural protein NS-s	Finn RD, Bateman A	anon	Pfam-B_880 (release 3.0)	Family	The NS-s protein is encoded by the S RNA. This segment also encodes for the N protein.  These two proteins are encoded by overlapping reading frames.	25.00	25.00	33.20	33.20	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.88	0.72	-4.51	24	277	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	72	0	0	221	0	84.00	44	97.52	CHANGED	M.hpshpl+Lhp+psMh+Lplshsps.hhl.LESSoShcRRPKlsshtcpsthhhLhLtuuphpaLIpIFhpTushpC.TosLPSTus.sT	....M.h.t.phcLh.h.thhcL.lshs.p.hLl.LtSSSSh.pRP+LhShhppsshLhLpLtuuphph.IhIFhpTushQhhTTlLPSTss.sh..	0	0	0	0
+1409	PF03231	Bunya_NS-S_2		Bunyavirus non-structural protein NS-S	Bateman A	anon	Pfam-B_3018 (release 6.5)	Family	This family represents the Bunyavirus NS-S family. Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase.	25.00	25.00	95.60	95.50	18.40	18.20	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.33	0.70	-5.91	9	245	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	30	0	0	244	0	410.40	68	94.52	CHANGED	MSosphs..................spphhpsYGop.Ds+AlsDsYslas.GcGpphlphhhaoNuthKouFuhsphG+stDlch...........cEtEllsopc.ashF-c...hsLsIshssc.hpllVp+PslpspGsKaphHspIhsPspshLphsss.....hscc-Fhcp.plpppchhPsshhl-tspKsshhlssssphslcYua.sVMGKs...ssa.tpshs+EhllosKpcsh.ssstssNRhLsspsVKuIpIu..S-ltss..opshLps+pshshclpsQh.RlShsulhcEsuhsRhFhls.-spsRhlhh.ucslsspsNtcTTLlIKllsKsh..sphssshsp...shpsChcs......ltsphGlVc.hhssDPs.YNphIs+sLLuVHTphAhslScsLpKPlIVFplhD.pELpscps-lsG+plsYpcDupGshYFLSpTL-.....hhPps.oolsYLsSht.s.WK.shstpchhlp	..................MSSSVYE................SIIQTRASVWGSTASGKAVVDSYWIHELGTGSpLVQ...TQLYSDSRSKSSFGY..TAKVGDLPC...........EEEEILSQHVYIPIFDD...IDFSINIDDSVLALSVCSNTVNsNGVKHQGHLKVLSP..AQLHSIGS....hMNRSDITDRFQLQEKDIIPNDRYIEAANKGSLSCVKEHTYKIEMCYNQALGKV...NVLSPNRNVHEWLYSFKPsF..NQVESNNRTVNSLAVKSLLMSAENNIMPN..SQAFVKASTDSHFKLSLWL.RV..PKVLKQlSIQKLFKVAGDETNKTFYLSIACIPNHNSVETA..LNIoVICKHQL..PIRKsKAPF...ELSMMFSD......LKEPYNIVH.....DPS.YPQRIVHAL.LETHTSFAQVLCNNLQEDVIIYTLNN.+ELTPGKLDLGERTLNYSEDuhKRKYFLSKTLE.....CLPSNTQTMSYLDSIQIPSWKIDFARGEIKIS.....	0	0	0	0
+1411	PF00952	Bunya_nucleocap		Bunyavirus nucleocapsid (N) protein	Finn RD, Bateman A	anon	Pfam-B_587 (release 3.0)	Family	The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein  is encode on the small (S) genomic RNA. The N protein is the major  component of the nucleocapsids.  This protein is thought to  interact with the L protein, virus RNA and/or other N proteins.	25.00	25.00	27.60	35.70	20.50	24.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.52	0.70	-4.35	17	354	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	96	0	1	246	0	197.20	55	97.72	CHANGED	FpDVPppssuTFDPEAuYluFpspastsLshsslRIFFLNt+KAKssLu+puc.pVsLsFGGhphsVVNsHFPt.psNPVsDsuLTLHRlSGYLARWll-pht.ss.pscpshl+opIlsPlAEspGhTWsDGsphYLuFhPGuEMFLpTFcFYPLsIshaRVh+ctMDspahcKslRQRYuslsA-pWhpp+hsslpuAhpsVspLsWu+ouhSsAARcFLupFGIpl	........F.DVsppssssFDP-suYlsFptpaspsLshssVRlFFLNttKAKssLp+psc.plslsFGshphslVNNHFPt.psNPlssssLTlHRLSGYLARWlh-php.ss.t.cpt.h+ssllsPlAEspGsTWs-.G..s....phYLuFhPGsEMFLpTFcFYPLsIshaRVh+shMDspahcKshRQR.Yu.thsAppWhppchstltsuhpsVtpLtWt+sshSsuARpFLtpFGItl........	0	0	1	1
+1412	PF04196	Bunya_RdRp		Bunyavirus RNA dependent RNA polymerase	Bateman A	anon	Pfam-B_2559 (release 7.3)	Family	The bunyaviruses are enveloped viruses with a genome consisting of 3 ssRNA segments (called L, M and S). The nucleocapsid protein is encode on the small (S) genomic RNA. The L segment codes for an RNA polymerase. This family contains the RNA dependent RNA polymerase on the L segment.	31.30	31.30	31.40	31.40	29.90	30.40	hmmbuild  -o /dev/null HMM SEED	743	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.13	0.70	-6.52	12	767	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	282	0	0	649	0	428.70	23	35.15	CHANGED	lshsRh.slhhu.p....hFh....ptshhhh.tps......s.hsh..shpphhp...hphLlslh.cK.phhtlhs.hR.Ylhhtshs.hSsh.chI.chF-c..psshshhhshhIKphlhshtp.sppshh..lplsshshp.pslts.tlhs.shh.tshhs.hcsLlsphYhshYhhsKshcschss.splhpchlEaEpchpppp..........phhth.............h+.hscuhhtphpppsthc..lc.ppsFppslsplushphsphshp.....p.pslcu..o.hscch.chps.ppht..p.........cthphphtccs........ahhupsls.....................hlpshhhsphsppp.shVlchhcpshphhchtp.........hp.hhhKtppptu...RthFltsl.p+lhhth.lEchscslh+hsspEhhopsts+c.hhlppthphth+atstcohhplupuDsu.................................hhsphhalotsho+hostsss..ahahhhlhhsslhhpKchhhslphlp.h...cp.hhhs-hhhphlcpthphpp..sh..ahstshs..hhtsctsahQG.LsasSSLhHush..ha+chht....cth.pl-..........shhchhppSDDuth.luh.t.spsttsphthl................phspthFphtcthhhhhsIh.hs.KpThso..s.hEFhSpF...FpGsshs..hh+hlhsulscstt.shhsDltphpsphsphlctGssspLs.ls.sspp.hshphYu.sssu.hss.tphlph.ps.....phPh.hhhhhstPhtththhGhphss	..............................................................................................................................................................................................................................................................p....h.s..h..................th.....................................................h.....h...h...............tp.h.t..........t................................................................ht.pt...............h.t.h...................................................................h.p..t.......hl.p......t.h..................h.......h...p.t...+.hal..h...h...h...th..thh....pch.t....t..........h....t....h..t.........p.....................................hht.h..hst.h.hhs....s..hhhhhhhhh.uhhpp+hh.hslphlh.h........cp.h..pc.hh.hh.t..thp...ph..hhp.h.....p.....h.hptshhQG.hphsSShhtshh..hhpph.......phh..h...............hhhp.h.tSsss...h......................................................................................................................................................................................................................................	0	0	0	0
+1413	PF03181	BURP		BURP domain	Mifsud W	anon	Pfam-B_1432 (release 6.5)	Family	The BURP domain is found at the C-terminus of several different plant proteins. It was named after the proteins in which it was first  identified: the BNM2 clone-derived protein from Brassica napus Swiss:O65009; USPs and USP-like proteins Swiss:P21746 Swiss:P21747 Swiss:Q06765  Swiss:O24482; RD22 from Arabidopsis thaliana Swiss:Q08298; and PG1beta from Lycopersicon esculentum Swiss:Q40161. This domain is around 230 amino acid residues long. It possesses the following conserved features: two phenylalanine residues at its N-terminus; two cysteine residues; and four repeated cysteine-histidine motifs, arranged as: CH-X(10)-CH-X(25-27)-CH-X(25-26)-CH, where X can be any amino acid [1]. The function of this domain is unknown.	20.70	20.70	21.00	21.00	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.91	0.70	-5.17	28	407	2009-09-10 21:17:04	2003-04-07 12:59:11	10	6	56	0	178	416	0	183.20	34	55.05	CHANGED	ulFFhEccL+sGsphs....ltFssssst...s..sFLPRphAcslPFSopcls-ILphFultssSspActhpsTlpcCE.ssu..hcGEcK.....hCATSLESMVDFusSpLGsp.slpAhS.Tts.s......tsstppYsl..suV+tls.u..t...sssVuCHp.sYPYsVFYCHpstp.o+AYtVsLhus-Gs.........tscAVAVCHpDTSsWsPp.HsAFplLsl+PGslPVCHFlspscllWs.p	...........................................s.haFh.p.lh..Gphh........hst.t...............hLs+t.....uppl.P.Fstpphstlhth.hsh..so..u.phhppslppC-...tss.......htGE..pK.....hCsoSlEshl-FshuhL...G...p........plp.......sho..oph.t........................hppYtl..tsV.pt..l.....s..s...............sp.VsCHp.sa....P....Ys.VaYCHp.h.........tt..s+sY.Vs.lhus.cus..............tspulAlCHhDTSt.Wssp.HhuFphLtscPG..p.s.s.....VCHalspsp.hlWs...........................	0	15	102	151
+1414	PF03309	Pan_kinase	Bvg_acc_factor;	Type III pantothenate kinase	Mifsud W	anon	Pfam-B_3452 (release 6.5)	Family	Type III pantothenate kinase catalyses the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.	23.30	23.30	24.50	24.40	23.10	23.00	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.49	0.70	-4.81	194	2298	2012-10-02 23:34:14	2003-04-07 12:59:11	9	5	2191	43	659	1901	2016	197.40	29	75.38	CHANGED	lLslDlGNTplhhulaptt..........thh.....ph+h..sosttps..........t-phshhltshhphtsh..............h..tllluSVVPshhtshtphhtch...ht......hpshh.......ls.sshph.GlshpY.c...sP..pplGuDRllsslAAhp.ha....s.s..hlllDh.GTAsThDsls..scG.p..alGGhIsPGlslthcALtppsApLP..plt...............htps.t..psl...GcsTssulpuGlhaGhsGhl.-tl...lp.......c	......................................................................LhlDlGNTphhhulhptt.................phht......ph+h.....ts.s.h.tpo...................t-ch..s.hh..l...p..phhp.h.tshp..........................tlhluSVV.Ps.h..h.t.s.h.p.p.hh.h.c.h.ht..........hpshh..............ls......s.shps...Gl.s.hta.c..s.P..p.p..lGuD.......RlsssluAhpha.........sts.hlVlDh.GTAsTh-h....ls.........tcG..p......alGGsIsPGltlphcALtppsAp..LP.p.lp...............lsp.s...t......ssl....GpsTssuhpuGlhaGhsGhl.-tllp.p.........................................	0	270	498	593
+1415	PF04681	Bys1		Blastomyces yeast-phase-specific protein	Mifsud W	anon	Pfam-B_5640 (release 7.5)	Family	The molecular function of this protein is not known. Its expression is specific to the high temperature, unicellular yeast morphology (as opposed to the lower temperature, multicellular mycelium form) [1].	20.90	20.90	21.20	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.02	0.71	-4.50	2	111	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	60	0	75	103	0	144.40	33	78.72	CHANGED	ESVlAKRADLGsAFVhlYCNFoVhLDlpAGtsSTR+hLsGRsaDYapE.YtsGSGDGVSLTLpHT-G.DSSNScTTFRYKLuDsNSTVtYSLGNSGGNPFtGHKlTLKsSsDtCPpIEWP-GIPTGVSSGSCGSutNLILThCP.tpshp-FEDE	................................................h..shs..........lGpAhVhN..pCshsVaL.a..Sluusl.us.tp.hl.s.stshphhpp.ha.+..s.s.s.u.GGluLKl.o.p.s.-.G.h..hs.u.ss.pThFsYsLsts......tspVaYDLSslFGs.P.F..sGpp.ls...l...p.......s.....o..ss......sC.....P.sIhW.s.sG.........l.........P.s.........G.s........p..s..p.sCt.ussclhLTLC............t......................................	0	7	27	58
+1416	PF00170	bZIP_1	bZIP;	bZIP transcription factor	Sonnhammer ELL	anon	Prosite	Family	The Pfam entry includes the basic region and the leucine zipper region.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.15	0.72	-4.01	22	5966	2012-10-02 13:17:30	2003-04-07 12:59:11	16	81	523	288	3305	7374	40	61.00	27	17.17	CHANGED	-cplK+p+R+.pNRpuA++sRtRKptchcpLpp+VcsLpsENttLtpclppLccpstpLptpsp	.............................++p+R.hhp.N.R.........t....u..A.....p+sRpRK.c............p...h.......lp.......p.......L.......E...p.......c...l..........p..........p....L....p....p.......p.......N.....p....p....L...p..........p...p.h..p...t...L....pp.p.ht.h.....h...............................................	0	830	1626	2510
+1417	PF00386	C1q		C1q domain	Finn RD	anon	Prosite	Domain	C1q is  a subunit of the C1 enzyme complex that activates the serum complement system.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.82	0.71	-4.13	46	2356	2012-10-01 20:41:10	2003-04-07 12:59:11	16	38	315	47	1129	1977	431	122.60	27	35.37	CHANGED	AFSsshspthsss.t.........slhFcc....llhN.tssYsssTGpFsCslsGlYaFsaplp...shppsltht..Lh+N...spphhthhsptpssp....psuSsuslLpLptGDcVWlplhst...suhhsspt.sposFSGFLl	................................AFpsshsps...h...s........p.........slhF-.p....lh..h.N....h........s...s.....p..Y...s...s.po...G.hFs.ss..l.sGl..Ya....F....saplt..................hpsppl..t.ls.....L.h+N...............s.p.s..h....h...t.s..h.sp.tssp................phuS....s.....u.....s....l....L..p.LptGDpValpl.tt..........puh.h.s.s.t...........th...oo..Fo.GaLl................................................................	0	266	375	622
+1418	PF01413	C4		C-terminal tandem repeated domain in type 4 procollagen	Ponting CP, Schultz J, Bork P	anon	SMART	Domain	Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.	19.70	19.70	32.60	20.30	16.50	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.79	0.71	-4.17	26	1172	2012-10-02 16:37:33	2003-04-07 12:59:11	14	49	94	40	532	965	0	108.20	49	15.42	CHANGED	uhhlshHSQopslPpCPtGhspLWpGYShLhhsu.sscusGQsLuoPGSCLpcFpohPFl.Css.pssCpYhu.NchSaWLoTsp.......tPhs.s.hsG.plcsaISRCpVCpts	.......................hllshHSQo..hp.l..P..p..CP.....t.....GhppLWhGY....S.hLhhpu..spcupGQsLu....osGSCLccFpohPFl.Css..pssCpYhu.NcYS.aWLoTs.......p...........................tP...hs....s.h....s....G.....plcshI.S..RCpVC.t..................................	0	125	159	312
+1419	PF03595	SLAC1	C4dic_mal_tran;	Voltage-dependent anion channel	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Family	This family of transporters has ten alpha helical transmembrane segments [1].  The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterised as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore [2]. Many homologues are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.	26.20	26.20	26.90	26.40	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.30	0.70	-5.79	159	2801	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	2089	12	789	2007	101	296.00	22	86.74	CHANGED	pphsssaFuhsMGhuulu...hh........ht.................h......h.......shhthluthlhhlslhlall..hhhh.hhh...+hlha..p..thttp.........h....pcPlpusFhsshshuh.hhlsshhhhh.....................................hhhluhsLWhhuss.lplhhshhhhh..................thh..t..pt....hphpp..hsPuW...hlPhVushlsussu..shhs.....................hhhhuhhhauhGhhhhlhlhsll.hhRlhhpphhsps...........hhPohhIhluPhuhuhhuhhtls..............................................h....shsshhuhhLhshuhhhhhlhlhthhph..................hph............................sF.shuaWAhoFPlushs...hushph.........sthhs...hthhphluh...................hhhhhhshhhhhlhhtslt	....................................h..hPhshhuhslGhsuhu.h...ht...............................................h............th...t.h.lut..hhhhl.uhllahh.........hlh......+hlha...c.....phhtc.............l....pcPlhushhsshshuh..hll.ss.hhh.h.....................................................h..luh.s.......lWhhuhl..lplshhhhhsh..............................thht..t..t...............h.phcp....hsPuW..hlshVuh.h.lsu.ssu...sshu.........................hh.huhhhhuhGhhhh.hhlhsll...htRL.h.........h..ps.......h.sps...........hpsshhIhhAPhulsssuhhtlst.................................................................s.sshhshh..Lhshuh..hhh.hhhlh.h.h...p.h......hpt............................sF...ssua..h..uaoFPhshhA.suhhph...........uphhp....................s.h.h..chLuh....................h.hlhss.hllhhlhhthl.h..............................	0	203	426	638
+1420	PF01681	C6		C6 domain	Hutter H, Bateman A	anon	Hutter H	Family	This domain of unknown function is found in the C. elegans protein Swiss:Q19522. It is presumed to be an extracellular domain.  The C6 domain contains six conserved cysteine residues in most copies of the domain. However some copies of the domain are missing cysteine residues 1 and 3 suggesting that these form a disulphide bridge.	25.00	25.00	25.10	25.20	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.69	0.72	-3.93	35	172	2009-09-12 03:01:09	2003-04-07 12:59:11	12	10	7	0	169	145	0	94.00	21	48.65	CHANGED	Csssshshuhusspsst.....shsshhssshsso..tsssoohploCsuhss..hpsshhlss........ssssspsus.s.....o.lslshsC..sssuhWhY............sss..pslsol.sC	.........................CpsCs.h.hh....hsts........hsshhshstsss...ssCpsh.sloC.pusss......sps..shhhss..........ssssspsus..u......s.sshslsC...sssu.p.Whh.............hu..pslsslsC...............	0	72	92	169
+1421	PF03596	Cad		Cadmium resistance transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.00	20.00	20.50	20.00	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.28	0.71	-4.60	6	922	2012-10-03 02:02:08	2003-04-07 12:59:11	8	3	734	0	141	604	8	185.00	42	92.57	CHANGED	YhuTulDhLlILhlhFuchKppKphhcIalGQYlGoshLlllSLlhAalls.hlPEcWllGLLGLIPIYLGIKlhIhG-..---EpplhctLpppKhspLhhTVshIThAS.GADNIGlalPYFsTLohspLllslllFlIhIhlLsalup+LAslPpluETlEKYuRWIlslVaIuLGIYIllENsThsslLoh	........................................YhuTulDhLlILhlhF..Ap.hp.p..............p..K...p.............h..h.c.IYhGQ..YLGo.sh.Llh.sS.Llh.AaV.ls.al.Pp.cWl...lGLLGLI.PIaLG....I.....+....h...h........l...........h....s-.............s-..s.E...c...c.....h....hc...p........L........p........t........p..t..........h.............s.............p....L...........l...........hs........VuhlTlAS.GuDNlGlalPYF.soLs.hsplllsLllFllhIhlhshhuphLuslPhl..uEsl.EKapRhlhslVaIuLGlaIlhENsTlphhh.h..........................................	1	36	78	122
+1422	PF00028	Cadherin	cadherin; 	Cadherin domain	Sonnhammer ELL	anon	Swissprot_feature_table	Family	\N	28.80	28.80	28.80	28.80	28.70	28.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.07	0.72	-3.73	57	41902	2012-10-03 16:25:20	2003-04-07 12:59:11	12	548	328	141	21785	37651	1579	93.10	24	44.86	CHANGED	hphplsEst....ushlhplsupDtD...tsssspltYplhpss.....sphFplsspsGp........lpstps..LDcEph.........spYpLplhApDp.........h..shssssplplplt	....................................................hpl.E.s.s..s.......s..G...s.....h......l........h........p.......l........p....A..p...D....t.D..................tu..t..N......u........p........l....p..Y...p...l.....h......s...s.s....................................tshF..p....l..s.......s...p.o.Gt........................................lps.......t....p.......s......L.....D...p..Epp.......................................sp..a.p..l...p....l.p.A...pDt....................ut.s..s...h...s...u....s..s.p.lplpl...................................................	0	4217	6276	12981
+1423	PF01049	Cadherin_C	Cadherin_C_term; 	Cadherin cytoplasmic region	Finn RD, Bateman A	anon	Pfam-B_257 (release 3.0)	Family	Cadherins are vital in cell-cell adhesion during tissue differentiation.  Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the   cadherin.  Cadherins cluster to form foci of homophilic binding units.  A key determinant to the strength of the  binding that it is mediated by cadherins is the juxtamembrane region of the cadherin.  This region induces clustering  and also binds to the protein p120ctn [1].	21.70	21.70	21.90	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.84	0.71	-4.17	64	1652	2009-01-15 18:05:59	2003-04-07 12:59:11	12	99	108	11	822	1256	0	136.60	35	14.31	CHANGED	R++ppp....h...........t.-c...DlR.ENllpY-DEGGGE-...D...ppuaDlssLppshss....................ptshhP.hthhs.................................ssssltpFIpc+lccsDsDPs.uPPaDoLpsYs...YEGsG........SsAGSLSSLs.Sso.o-u-p..caDYL.ssWGPRF+KLA-hYGsp	...................................................................................................................................................p................h...c-.....DlR.-NllpYs-EGGGE-......D.........................pp.taDlu..tLpps.tht.................................................p.s.hP....h.............................................................pssph.tp..FIpp+.l.p.t.A.DpDss...sPPaDoLh......sYs...YEGsG.......................................................SsAuS.LSSLt..S..........so....ss........s.-p.........-.............a..-a.L.s-W.G.PRF+pLA-hYut.t....................................................................................	0	71	138	400
+1424	PF03507	CagA		CagA exotoxin	Bateman A	anon	Pfam-B_918 (release 7.0)	Family	\N	21.60	21.60	21.90	21.60	20.20	21.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.43	0.71	-4.44	4	2702	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	41	4	1	2704	1	133.20	62	54.67	CHANGED	NFSDIKKELNtKL.GNFNNNNN.GLKNSsEPIYApVNKKKsGQsASPEEPIYsQVAKKVsAKIDRLNQIASGLGsVGQAAuF.LK+HcKVDDLSKVGLSASPEPIYATID..DLG.GPFPLKRHDKVDDLSKVGLSREQcLsQKIDNLNQAVSEAKAGaFsNLEQpIDKLKDSTKKNslNLaVEuAKKVPsSLSA	.........................................................ph..tN...N.N.N.N.N.GLKN............EPIYApVNKKK.s.GQss..SPE.EPIYAQVAKKVsAKIDpLNph.sSu..lsthh......p.thsh.hptt..ctVsshSt..s.GpSs....S....P.EPIYATID..-hs....usF.PL+RpstVs.........D.L.S.KVG.LSR............p.Qc.L.s.p+.......lssLs.QA................................................................................................	0	1	1	1
+1425	PF03524	CagX	cagX; 	Conjugal transfer protein	Bateman A	anon	PRINTS & Pfam-B_5812 (Release 7.5)	Family	This family includes type IV secretion system CagX conjugation protein. Other members of this family are involved in conjugal transfer to plant cells of T-DNA.	25.20	25.20	25.50	26.70	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.32	0.70	-5.06	150	1580	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	797	15	335	1390	79	205.60	22	75.21	CHANGED	Ds+l..........phhsYssspl.hplhsssGhsosIthpssEpl....ts...luhGD................ossWplss.............ptsplhlK..............................Ppp..ss.hsTNlslsTs+.....RoYthcLpup.spshh............................htVpFpY..Pp...............t......ttttttttsssshtss....hphss.................hNap.Yshp...Gsps..hpPhp.laDDGphTalpFsss.hp....hPslFhlss...pG.....p.cplVNh+lps........shllVcplhpp.hhLRhG....pp.sVsIhp..s	..........................................................................................................h.Ys.sthhplhst.shho.l.ht.sEp.l.............s.....lshGs.......sht..Wplts........................tsstlhlK..............................P..hp....s..hp.TN.lhl.hTs+...........RsYphpLtstptp..h.......................................htlpap...Y..Pp.............................t...tt.tt.t.t...t.p....t..sp..p..tt....h.p...tp....................................................hsap..Y.hp................ustt....htP..p.......saDD..G..phTahpFstt.ht.....hPslahlss......u............p.pphlN.h.phps...........shh.llcplhtp.hhL+hG.....pp.hltlhp.s...............................................................................................................................	0	62	186	252
+1426	PF03185	CaKB		Calcium-activated potassium channel, beta subunit	Mifsud W	anon	Pfam-B_2176 (release 6.5)	Family	\N	25.00	25.00	25.10	26.30	23.70	24.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.46	0.71	-4.94	10	225	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	48	1	119	207	0	174.90	38	79.42	CHANGED	tK.+lsou.psGEDRAlhLGLuMlssSVlMaFlLGhTlLpsYhpSlhs-EusCsVLpssIt--.hpCsaoCGs-CcssSpYPCLQVaVNLosSGppuLLaasEEslcpNsK......C.YlP+CpcDppchpsplpslp-pF+cp...QsFsCaasPspppssVLLpRhYsppsLhHsLhWPolhLsGGsLIVlhVKLTQaLSlLsEch	....................................+hs.t.ptGEsRAlhLG..lsMh.ss....ulhhhFll.GhTlLpsa..h..p....S..l...s.pEupCol.lpsplh-p.......hpCsasCGs-Cpthu........pYPCLQV...aV......N.l..o....p...SG......p...p..s..lLa....asE.-sh......p......h.N..c..................CS..YlP.t...........Ct..c.shpcsh...spV.slpp..accp...psFsCahsspt..p..csVlLp+hYst.slhHslhWPsh.hh.h..sGslIlshshhsp.Lulhstt.......................................................................	0	26	31	56
+1427	PF00214	Calc_CGRP_IAPP		Calcitonin / CGRP / IAPP family	Finn RD	anon	Prosite	Family	\N	21.60	21.60	21.60	21.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.80	0.71	-4.11	13	313	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	68	21	149	310	0	106.10	29	83.67	CHANGED	MsllphSshLss.lhsL..............pphsthpAsPhRpsL-shss..ss....cst.h.thlh.p.hp.php..ptppppt.....ttsts.......ucKRuCshuTCssp+LAchLsphss.hpsshuPss.luspuaG.RRRRul	...................................................................................................................h.........hh...................................t..h...................t....t......h.thh..t.........p..t.........tt..t...........t.ppp............hpKRsCshuTCssp+LuphLt+....s.s...t...pshsPTs.lGspua.G.++Rp........................	0	9	21	58
+1428	PF04847	Calcipressin		Calcipressin	Mifsud W	anon	Pfam-B_4547 (release 7.6)	Family	Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.31	0.71	-4.71	9	405	2012-10-02 20:46:34	2003-04-07 12:59:11	7	4	237	1	233	376	0	174.90	37	76.73	CHANGED	.pVFsssps+.........pphcsLapphscslpaphl+SF+RlhlsFss.psAtsA+hphc............t.phpG+p......l+haFu..Qs.ss..sssspaLtPPpssKpFLISPPuSPPsGW-..tp-ssP...ll...saDLhtALupLs....................................................tEchpl+sss.-ssPulll.....+sspst.pttt..............tscschspTpRPsh	.....................................p..h.t.p.h.........pphcs..Lappa.s...c....h...oF.....phh.....KSF...+...R...lhlsFssspuAscARh....pL..+.................pp..ph.Gcc...............h+lYFu............Qs.s......................hs....p..pa......LtPP..p..s..sKQFLISPPuSPPlGWc.......tp-ssP....Vl...saDLlt.Al..u..+Lus.......................................................................................................uEp.hE....L+sss....-ssPollV........+sspsp..p.tpt.........................................htts.+..pl.h.pTtRP..h............................................................................................	0	60	98	163
+1429	PF02029	Caldesmon		Caldesmon	Mian N, Bateman A	anon	IPR000075	Family	\N	50.00	50.00	50.80	50.80	48.70	49.70	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-12.95	0.70	-6.07	10	234	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	39	0	77	177	0	296.00	32	83.25	CHANGED	DDDEEEAARERRRRARQERLRQKpEE-shGQVo-psEssuQNSVssE-sKsoo.po...t.tsDDEAALLERLARREERRQKRLQEALERQKEFDPTlTDuSlShsS.RRhtND.su-NppsEKEE+pEuRppRpElEETEsVoKScQ+NsacDsE-ccp--+.+EccEEEc.c.tohtpN...............................................................................................................................................................................................................................................................p.hc-phcK-KtsK.-hKphhDtK+Ghs-.KuQNG..EhhT.KLKpsENsFS.s..tt....st.scsA.psEAG++LEEL+RRRsEhEsEEFEKLKQKQQEAAlE..LEELKKKREERRKVLEEEEQ++KQEEA-RKsREEEEKRRhKEEIERRRAEAAEKRQKhPEDGlSE-KKPFKCFoPKGSSLKIEERAEFLNKSlQK.SGVKsoHpsAVVSKIDSRLEQYTsAIE.GTKuuKPsKPAASDLPVPAEGVRNIKSMWEKGNVFSoPuusGTPNKETAGLKVGVSSRINEWLTKTP-GsKSPAPKPS.DLRPGDVSuKRNLWEK	.......................................................................................................................................................................................................................................t.t...ttp.............t......p.c.p...p..tt........p.tp.p..t.............................p...t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...........t...................................................................ttt...t..........t..............................................so...h+l.-RsE.LN+ShpK....suh+.sp.s..lucIDphL-QYTpAht...ts+ts+..+.ss.-Lss...s..ltshKohaEtGps.....tsss.ss..K-............................................................................................	0	3	9	28
+1430	PF05042	Caleosin		Caleosin related protein	Moxon SJ	anon	Pfam-B_5163 (release 7.7)	Family	This family contains plant proteins related to caleosin. Caleosins contain calcium-binding domains and have an oleosin-like association with lipid  bodies. Caleosins are present at relatively low levels and are mainly bound to microsomal membrane fractions at the early stages of seed development. As the seeds mature, overall levels of caleosins increased dramatically and they were associated almost exclusively with storage lipid bodies [1]. This family is probably related to EF hands Pfam:PF00036.	20.60	20.60	20.60	21.10	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.04	0.71	-4.71	9	275	2012-10-02 16:17:27	2003-04-07 12:59:11	8	3	97	0	153	262	3	155.30	43	68.07	CHANGED	+-pcphSVLQQHVAFFDpscDGIlYPWETYpGhRulGhshlsShhhulhINluLSYsThPuhhPS.hFPIaI+NIH+AKHGSDSusYDsEGRFhPsNFEpIFSKaA+TtPDtLThtElapMhcuNRsshDhhGWluupsEWhLLYhLA+Dc-GhLpKEuVRtsFDGSLFEpltK	...........................tthosLQpHluFFDpspDGlIaPh-TapG.hRsl.......GhshhhShhsshhIphsh..Sh.T..h..s.......u.......h..h..............Ps.Ph.F..sIYlcNIH...+uKHGSDous.YD.sEGRFlPtpFEpIFuKa..A.+s.t.s.......-tLThtEl.hphhpu...pRp...shD.hG.W....h.....u...uhhEWthhYhL.s...pcc..-G.h..l..pK-slRthYDGSlF.hlt....................................	0	38	83	123
+1431	PF00915	Calici_coat		Calicivirus coat protein	Bateman A	anon	Pfam-B_202 (release 3.0)	Family	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.92	0.70	-5.50	11	9404	2012-10-04 01:49:40	2003-04-07 12:59:11	15	15	8145	108	0	7359	0	130.20	53	60.76	CHANGED	hhASsD........AssssDGsuuss.lsPEsss.ssshsh-PssuutsAsAsuGpss.lD...sWhts.aVpsshu..TlsPp...GclLaslpLGPcLNPYLuHLSpMYsGWuGuh-VRlhlAGsuhhAGKllhuslPP..ul-slossphshaPHVlhDsRpLEPV.hslPDVRNshaH.ss.sssTh+LVhMlYsPLhsssuus..sshsluspV.T+PSsDFsFhhLhPP..plEppopP...holPplohpphuN.Rasu.IsuhhlsPs..hshQ.pNt+hshDGphhG...hSssplsslcusls	.................................................................................................t................s.s.Du.s.uu.ss..L.V.PElN.........NEsMALEPVsGAulAAPlu....G.Qp....NlID....PWIpN..N.FVQAP..sG.E.FTV..SPRN......uPGEl.L.hsh.L.....GPc.....L.....N...........P.....Y....L.....u.....H.....L....up.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+1432	PF01067	Calpain_III		Calpain large subunit, domain III	Finn RD, Bateman A	anon	Pfam-B_852 (release 3.0)	Domain	The function of the domain III and I are currently unknown. Domain II is a cysteine protease and domain IV is a calcium binding domain. Calpains are believed to participate in intracellular signaling pathways mediated by calcium ions.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.03	0.71	-4.56	91	1670	2009-01-15 18:05:59	2003-04-07 12:59:11	17	64	274	9	868	1478	9	140.30	28	20.07	CHANGED	pW...phshhpGpW.h.....pGs...TAGGCpNa.t.........TFhpNP.............Qatl...............plp-s--p.t..........................sslll..........uLhQ..............KscRpp+p...........t.c.hs........IGFslacl..........t.plsppahhpp...tshspopsahNtREVspR.hpLsPGc..YlllPoTFcPspcu-F.hLRlFocptsptp	............................................................W.p.thhpGpW.h..........pGs.....oAG..G....C.p.N.h...t.................................TF...hpN.P.................................Qa..hl...............plpcssct.........................................slll..........uLh.Q................+s.p.+.p..tpp............................tt.phhs................IG.Ftlacs...................................t.ph..p.pp.h.hhtp.................tshspo.t.s.a..h...s...t..R....-..Vsp..c..hpL.....s...P.Gp......YllVPST....a.....cPpp.pu.cF.h..LRlaoct.....t...................................................................................	0	247	356	615
+1433	PF00748	Calpain_inhib		Calpain inhibitor	Bateman A	anon	Pfam-B_543 (release 2.1)	Family	This region is found multiple times in calpain inhibitor proteins.	20.80	20.80	21.00	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.84	0.71	-3.82	24	632	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	49	7	111	594	0	125.40	35	73.52	CHANGED	lDuLSpDFosut...........st.ssuptcppcschssssu-slpts..ssssspouuPs.sp..psp....h.-DAL-sLusSLGpRpsDP-..-sKshtDcVKEKu.KcE+p-KLGE+--TIPP-YR.Lh-scDK-GKPhhPcs..cc	.......................................................................................................................lDtLSpDFst........................t..sstthp..pp..t.....t...tshs.Esl.sts.......ssss.sp...ou.sP...sp..t..tsp................h..D.s.AL-sLusSL.G.p.+p.s.-.P-...-sps.ht-cVc..-Ku...KpEch-KLGE+--TIPP-YR.Lhssp.c..ccG+PhhP.....p................	0	4	12	40
+1434	PF00402	Calponin	calponin; 	Calponin family repeat	Finn RD	anon	Prosite	Repeat	\N	21.10	21.10	21.30	21.20	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.67	0.72	-6.68	0.72	-4.59	5	1168	2009-01-15 18:05:59	2003-04-07 12:59:11	13	17	129	0	595	1070	0	25.20	59	20.32	CHANGED	luLQMGTNKaASQpGMTuaGtsRall	.....IuLQ..MGT..N..K.sASQuGMTu...aGssRpl.........	0	145	202	400
+1435	PF00262	Calreticulin	calreticulin; 	Calreticulin family	Finn RD	anon	Prosite	Family	\N	19.60	19.60	20.60	20.10	18.70	19.00	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.66	0.70	-5.82	68	1064	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	414	14	509	1004	21	294.80	45	68.78	CHANGED	saFhEpF.ts......thpp+Wl.Sptptpt.......t....hGcaplpsu.thhsshptD+GLhhppcA+aaAISs+..hspPhssc.s..................................KsLVlQYpVKhp.psl-CGGuYlKLhssshctp.....p..hs....scT..sYpIMFGPDhCG.ssK.lHhIh.........shhtcpalhptsh.p.....ssph.THLYTLIl+PcN.oaElhIDscpspsG.sLhcD.....ac..h.PPKcIcDPp-cKPcDW-DcthIsDP.cspKPEDWD......................c.PchIPDP-ApKP-DWD....--hDG-WcsPhIsNP.....................cYKGcWps.hIcNPsYKGhWtPpcIsNP-YhpD..p.h.h...s.lsulGh-LWpspushlFDNlll	..............................................hF.EpFpps........hp.scWl.Sptcpp.................Gpaphpts...h..ss..httD..........+..GL.hppcA+aaAlSuc..h..s.sassc..s..................................+sLVlQapV+ap..psl-CGGuYlKLhssshs.p......p..hp....scoP.YtIM.....F........GPDhCG.ssK..lHhIh...............shhtcpHh..h..p...shtt.....hsDph.THLYTL..IlpPDs.oaplhlDspthpsG..s.L.pD.....as...h..PP+...cIcDP...pspKP-..DWD.-.+tpIsDP.pshKP-...DWD.................................p..P..chIsDP-ApK.......P-DWD....--.DG-WcsPhIsNP......................pYK.GpWcs..IcNPsY+GhWh..cIsNP-ahtD...p.h..hh..pshsslGh-lWp......h...pushlFDNhlI.........................................	0	167	255	377
+1436	PF01216	Calsequestrin		Calsequestrin	Finn RD, Bateman A	anon	Prosite	Family	\N	19.70	19.70	19.70	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.37	0.70	-5.69	3	208	2012-10-03 14:45:55	2003-04-07 12:59:11	12	5	67	13	84	623	10	299.80	55	93.70	CHANGED	KsPaLhLAuLhLLlu...p.GsRGEEGLDFPEYDGcDRVIslotKNYKsVLKKYEVLALLYHEPluDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLDEEDSlYVFKGDEsIEYDGEFSADTLVEFLLDVLEDPVElI-Gc+ELQAFENIEDEIKLIGYFKSEDSEHYKAFEDAAEEFHPYIPFFATFDuKVAKKLTLKLNEIDFYEPFMDEPITIPDKPNSEEEIV-FV+EH+RPTLRKLRPESMYETWEDDLNGIHIVAFAEEuDPDGYEFLEILKpVAcDNTDNPDLSIIWIDPDDFPLLVPYWEKTFcIDLS+PQIGVVNVTDADSVWMEMDDEEDLPTAEELEDWIEDVLEGEINTEDDDDDDDD	......................................................................h...........hh.........s.u-c...GLp.....a..P...pYDG..hDRVhs.l.stKNaKp.sh.K.+.a.c.h.h.sl.hY.Hp.s.....ss.+s.Q+Qap......h.pEhhL.EL...........s.AQVh......E.....c.....+.....s..lG....Fsh..V....Ds..p..K.-..s..t..lAKK..LG.hpE..sSlYl..hK..t...-..c...h...I...E.aD.Gp.....h..uADsLVEFLhDl.l.E.D.P.V..El.I.p..sphElp.uF.-p..h..E..-..c...I...+..L.l.G.aF...K.sc-..S..-.a...Y..+.....A.Fc-A.AEc..FpPa...I...FF.A.TF.-.pt.VA....K.+L..sL...K..h.N.E............l.....D..F......Y......E.P......F....M.......-...E...P....l..s...I.P...s.K..P......o..E.c.El.V.pFl..ccHp.RsTL...R+L....c.s..-..s..MaEsW...ED.D...h.s.GhHI.V...A..FA.E.ctDP..DG.a.E.F.L.EhLKpVApDNTc...N...P.-.LSIlW.IDPDDFPL..........LlsYWEKTFpIDL..t.PQIGVVNVoD.ADSlWh..-hs.....s.......--.DLP......os-ELE-WlEDVL.pGclss-D......DDpcp..p.................................................................................................................................................................................................	1	20	26	47
+1437	PF03160	Calx-beta		Calx-beta domain	Bateman A	anon	Bateman A	Domain	\N	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.19	0.72	-4.05	32	5074	2009-01-15 18:05:59	2003-04-07 12:59:11	9	429	918	46	2189	4984	1811	97.30	27	17.36	CHANGED	sslslh...D.sDts.hlsF-pspapl...EssGt.splpVsphu.GslppsVhVsapTtD.GT....Apu..GsDY..psspupLsFsss.pst.pplpls.l....lDD-lhEps.EpFhltLs	.........................................................................................t...p-.......s....hh..........a....p.t.....s...p........h.....p..s........tE.....s......s......G.....s.....l....p....l.s.V....h....R.......ps....G..........s....................s....s....s..........l..........h....V..s..a..........p...T....t......s......G..o......................A..p.s...........G.........s.........D..Y...............ps.s.........p...u..........s....l........s.....F...t.s......G....co................p.....p.......plpls...I.....................l-.D...s...h...h...Ets..Es.FhlpL......................................	1	821	1173	1655
+1438	PF01213	CAP_N	CAP; 	Adenylate cyclase associated (CAP) N terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	27.00	27.00	27.10	27.80	25.90	26.90	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.97	0.70	-5.14	6	489	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	282	4	291	479	4	263.70	35	60.01	CHANGED	hppLlcRLEpATuRLEuVs.......sshhRss..............GssssPou.....slAu........................sssslpAFcshhuphlutalclS+cluG-VtppuEhVcpAFpsp+slLpsAupsp+Psps..cLt-LLKPIsEpItcltshREcNRuSKhFNaLSAlSEuIshLGWVuVsPpPssaVpEMcDuApFYTNRlLKEaKcsD.cpV-WV+uYLslhs-LpAYIK-aHTTGLoWsKcG.susstoAhsussouusssP..........PPP....PPPPPP.ssshhppssEuspu.s.psuhuAlFApLNpGEuITpGLKKVocD.KTHKNPsLRspss.sso...PKs.hpsPsP	..........................................................................tllpRLEtsssRLEshs.................t....................................................s.........................ts...............................s...lp.sF.D.p.h..l.st.ls.palph...Spplu.u...V.......tp......p...........uphltpua.p.p+thLhhus.ptppPs.s.....thtplLp..Plsctlppltsh+.Ep.s.Rs..St.h.FN.H....LouluEulsuLuWls.......h...s......s....p......PssaVpEh.suApFYsNR..........VLK-aKc..p..D......pHV..-..Ws+uahpl.h.p.pLpsY....lK..paass.GlsWst.p.G...........h........t.........h...........s..............t...........s..s...s..s.....s...s..P.......................PPP.............Ps.P.PPP...s.ss...t..................t......s.t....t.........tsshu..AlFupl.N.p.G.ps.l.T.p.u.L++Vscs.hTH.KNP.sLRstss.s.stt....st................................................................	0	91	146	225
+1439	PF04451	Capsid_NCLDV	Capsid_Iridovir; 	Large eukaryotic DNA virus major capsid protein	Kerrison ND, Coggill P	anon	DOMO:DM04206; Iyer L	Family	This family includes the major capsid protein of iridoviruses, chlorella virus and Spodoptera ascovirus, which are all dsDNA viruses with no RNA stage. This is the most abundant structural protein and can account for up to 45% of virion protein [1].  In Chlorella virus PBCV-1 the major capsid protein is a glycoprotein [2]. The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, are referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV. The virions of different NCLDV have dramatically different structures. The major capsid proteins of iridoviruses and phycodnaviruses, both of which have icosahedral capsids surrounding an inner lipid membrane, showed a high level of sequence conservation. A more limited, but statistically significant sequence similarity was observed between these proteins and the major capsid protein (p72) of ASFV, which also has an icosahedral capsid. It was surprising, however, to find that all of these proteins shared a conserved domain with the poxvirus protein D13L, which is an integral virion component thought to form a scaffold for the formation of viral crescents and immature virion [3].	25.00	25.00	26.50	25.50	19.20	23.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.29	0.70	-5.33	37	809	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	193	9	0	474	1501	166.00	33	55.42	CHANGED	ssshsssp..las-YlaLDstERpthupss+-YLIEQlQhtsppsh.....sssssspplcls...FNHPsKhLhashp....................................s..stsshsshhss....................s.ss.ssshh............................................................................................................sslpsupLhhNupcRFsppsup.YFshVQP.apphsps.Pss.......................GlahYSFuL.sssshpPsGohNaSRlcsspLplshps......................tsshssspshp.lhlaAhNaNlLRltsGhuGl	.........................................................................................s..............................................................................................................................................................s...........................................u.Pshssshsshs.h...................................................................................................................shs.l.pslolhhcsh..s..h.lsp.h.ssc..ahoth.P.aaa..ussh.....ps......................sGhhhhoaAL..shpc.hpPSGphNhuRh..pp..hh..lshcss................................hs..shpp.hc.LlV.AsshNhh.....................................................................................................	0	0	0	0
+1440	PF05159	Capsule_synth		Capsule polysaccharide biosynthesis protein	Bateman A	anon	COG3562	Family	This family includes export proteins involved in capsule polysaccharide biosynthesis, such as KpsS Swiss:P42218 and LipB Swiss:P57038.	20.00	20.00	20.00	20.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.64	0.70	-4.92	23	1766	2012-10-03 16:42:29	2003-04-07 12:59:11	9	20	670	0	306	1577	451	256.20	23	64.77	CHANGED	-sllhaGsctshcthtth..........pppshshhplE-GFlR...ths.th..PholslDchGlhaDsspPsch-plLpp.................shhststhspspphhshlhppploKYs..................................hpht...p...sps+chlLlssQVhsDtulp.huss...shpshtplLpsstccsP.suplllKsHPtshutp+h............uhhsph.t.tctsplhscDsshhsLlcpsctVhTloSpsGhEALLpsKsVhs...hGtsaYusaGLTpDtphp.......ppptph........slt.Lhstshlpa...............shY	.......................................................................................................................................hhha.s..p...t...h............sp.t.h...th...hh.hhE-GalR......................P.....hsl....sh-...chG.l....hsus..h.....P...p....ch.c...hlpp.............................................h.st..t...h.t...h...shth..h.p.h.l..hp..tp.h.s+Yp..............................................................................................t...........t........th.ppchl.Lls..hQ........l......sDssl...p..htss...............thpth...hchl..p..s.....h.t...p...c..s..P....puh..............l.l.hK...H..P..t.s..h..ut.pch.................shh.s..p..........t...hptt...h.h.h..s.c.s..s..sh....s.L.lcp.sctVhTls.S.p.sGh-A.LlpG+sVhs...hGhsaYs..thG..LT...p....ct...h........t.......tpp.ph.....................ht..Lhtss..l.hshY......................................................................	0	70	165	239
+1441	PF00194	Carb_anhydrase	carb_anhydrase; 	Eukaryotic-type carbonic anhydrase	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.20	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.50	0.70	-5.41	14	3112	2009-01-15 18:05:59	2003-04-07 12:59:11	16	24	954	506	1486	2849	68	215.10	26	65.40	CHANGED	WGYscpsuspp........WsphaPlAs.....GpRQSPIsIpopcspaDPSLKPLslSYssuoup..plhNsGHohpVpF-Dops+oVlpGGPLs.us.YRLhQFHFHWG..uscppGSEHTVDGh+YsuELHLVHWN..sKYssasEAhspsDGLAVlGlFlKlG..stpstlQ+llDsLssI+pKGppsshssFDPssLLPs...shDYWTY.GSLTTPPLpEsVTWlVhKEPIslSspQltpFRsLLhsscs-pth......hhsNaRPsQPL+sRsV+ASF	...............................................................................................................................................W.........t.............s.........s.t.......G.pp...QSPI...s...l......p...p.p..t...h.............h.......s.....s.........p........h.................t..s..l...p..h.....p..h.............t....t.....pl..h..N.s..G.+..o......l........p......l...p...h.................p......s.................................................h............l......pG..s........h......t..p.....a..............p.............htp.....hH.a.Hh................................sS.EHpl.....s.G....p...p..a..shE...h..H...l....V..Hh................s........................................................p...s...s....s....l......u...V.lu.l......h...h......p......h.u..........p....p.....s.....s...................h....p....t..l...h....p..t....l......t....t....l......t................t.............s.............p......p...s.............h.....t....s.......h.....s....h...p.......p.L..l..Pp.........ptp..Y.....ap.YpGSLTTP.......P...Cs..E.s.VtWh...lh.p.p.s.lp......l.op...........p................Q..............l........t..t.h................p.p......hh.........................................................t.N.Rs...Q..httR.l................................................................................................	1	360	612	1041
+1442	PF02977	CarbpepA_inh		Carboxypeptidase A inhibitor	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.50	21.50	43.10	42.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.80	0.72	-4.38	7	15	2012-10-01 19:46:11	2003-04-07 12:59:11	10	1	5	4	0	18	0	45.30	45	51.05	CHANGED	spshlssCNc.CsopuDC.GhThC.........ta...C.+hppossGhshpthulhs	...oNsLGTCNcYCsTNuDChGlTLC.........sW...C.Kh+KosuGhshupCulhP...	0	0	0	0
+1443	PF00619	CARD		Caspase recruitment domain	Ponting C, Schultz J, Bork P	anon	SMART	Domain	Motif contained in proteins involved in apoptotic signaling. Predicted to possess a DEATH (Pfam:PF00531) domain-like fold .	23.90	23.90	23.90	23.90	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.56	0.72	-4.15	60	1660	2012-10-01 21:41:45	2003-04-07 12:59:11	16	127	129	33	789	1599	1	84.60	21	14.74	CHANGED	pphlcppRhtLlpplt...lst...lLDtLhpcpVLspc-h-plpp...pso...pts+.sRp..Llch.l.p+GsputphFlpsLpc..tpstLsphlptp	........................................phlcppRhtLlpplp.......lpt...ll..D.tLhp.pp......lls.pp-h-plps.....pso....ptp+.scp........Ll.-h.l..p.+G...p....p.u....hphF.lpsLpc....tpstLhp.l...t..................	0	218	269	437
+1444	PF01623	Carla_C4		Carlavirus putative nucleic acid binding protein	Bashton M, Bateman A	anon	Pfam-B_808 (release 4.1)	Family	This family of carlavirus nucleic acid binding proteins includes a motif for a potential C-4 type zinc finger this has four highly conserved cysteine residues and is a conserved feature of the carlaviruses 3' terminal ORF [1]. These proteins may function as viral transcriptional regulators. The carlavirus family includes garlic latent virus and potato virus S and M, these viruses are positive strand, ssRNA with no DNA stage.	20.70	20.70	21.00	20.80	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.42	0.72	-4.24	10	194	2012-10-01 20:03:16	2003-04-07 12:59:11	12	2	43	0	0	207	0	89.70	45	82.40	CHANGED	h+scslhplhcslacp.usshsh-lshsIlshsss+.lut..GRSpYARRRRA+SIGRChRCYRVaPP.hsFoo+CDN+TCsPGISaNh+VssFI	..........................................hhhhllhthh.ch.sshhshclC.VsIhp.hsucsVut...GRSoYAR+RRA.tsIGRChRC.YRVaPP..hpso+CDN+TChPGIShNh+VtsaI.........................	0	0	0	0
+1446	PF00997	Casein_kappa	casein_kappa; 	Kappa casein	Bateman A	anon	Pfam-B_1298 (release 3.0)	Family	Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.	25.00	25.00	32.80	32.70	19.00	17.90	hmmbuild  --amino -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.93	0.71	-4.53	9	256	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	142	0	12	240	0	137.40	73	97.48	CHANGED	ElQNQEQssCpEp-ERlFcpcpVhYlPlhaVLNpaPpYtssYYQpRsuls.hNN.ahsaPYYs+PlllRspAQIPpWQshPNh..........sTssR+PtPHPSFlAIPPKKhQDKTsIPsINTIAslEPTP..lPTs......EPsVNoVssPEASSE.I..STPETTTVsVTSsss	.........................h.p+hs.YlPh.YVLspYPpYGLNYYQQRPVAL.INNQFLPYPYYAKP.lAVRSPAQhLQWQVLPNTVPAKSCQsQPTTMARHPHPHLSFMAIPPKKsQDKTEIPsINTIASsEPTs..TPTT......EAlVNT..Vss.....EASSEsI.tSsPETNTsQVTSTtV.....	0	1	1	1
+1447	PF00363	Casein	caseins; 	Casein	Finn RD	anon	Prosite	Family	\N	21.80	21.80	22.60	23.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.74	0.72	-3.35	15	200	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	83	0	28	249	0	76.40	34	45.23	CHANGED	QlspLpphpp.phtls.spt....tp....hp...to..h..cpshholsQ...pphlphhpplhpa.p....hshhlpslhQYpcshh.Phsphts	...............................................................Q..pLsshps.pLsLs....hhps.......hcQ.....psh..o..hhs.pshholsQ.....+hLsh.ppls.a.Q....tsh.lQsh..h.........................	0	1	1	1
+1448	PF00302	CAT		Chloramphenicol acetyltransferase	Finn RD	anon	Prosite	Domain	\N	23.50	23.50	24.20	24.30	22.90	23.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.40	0.71	-4.70	12	768	2012-10-02 12:01:53	2003-04-07 12:59:11	13	6	590	61	135	572	473	191.50	33	93.28	CHANGED	MsFshIDlssWsRKEaF-HYhs.spCTYShTsplDITshhtplKcpuhKhYPshIYhluplVNpapEFRhuhsss.-LuhWDphpPsYTlFHc-TETFSulWo.acsDFspFhpsY.sDltpYucshphFPKsshPENtFslSulPWloFouFNLNltssssYLhPIFThGKYhpcssKlllPlulQVHHAVCDGaHsuRFlNElQ	.......................phlDhpsWpR+caFpaahp..ps.tauhTsplDlTt...hh...pt...hKpp.....shpFasshla.hls+shNp........htEFRhth.psp.plshaDplpP..sa.T.lh.p.pc.s.c..oFSslas...p.aps..DappF...hp...th.p...p-h.p.p.......htp.s...p...s.h......h.s.c..t...h....p.....N....h.h..l...SslPWlsFouhs...h.sh.s.s..sss..hh.h.Pl.hThGKah.p.c.s.s+lh.hPlulQlHHulsDGaHlupFhpclQ........................	1	52	92	122
+1449	PF03123	CAT_RBD		CAT RNA binding domain	Bateman A, Declerck N	anon	P39805/1-60 Psi-blast	Domain	This RNA binding domain is found at the amino terminus of transcriptional antitermination proteins such as BglG, SacY and LicT. These proteins control the expression of sugar metabolising operons in Gram+ and Gram- bacteria. This domain has been called the CAT (Co-AntiTerminator) domain. It binds as a dimer [1] to short Ribonucleotidic Anti-Terminator (RAT) hairpin, each monomer interacting symmetrically with both strands of the RAT hairpin [4]. In the full-length protein, CAT is followed by two phosphorylatable PTS regulation domains (Pfam:PF00874) that modulate the RNA binding activity of CAT. Upon activation, the dimeric proteins bind to RAT targets in the nascent mRNA, thereby preventing abortive dissociation of the RNA polymerase from the DNA template [2].	25.00	25.00	25.60	25.30	24.10	24.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.90	0.72	-4.28	15	2777	2009-09-11 00:54:21	2003-04-07 12:59:11	10	4	1579	7	291	1469	8	57.80	36	21.19	CHANGED	M+IcKlLNNNslllp.pcpppEtllhGpGIuFpKKtGDhlss.stIEKhFhLcscc.cpp+a	............hhIpKlLNNNVVl.sp....s..........cp.spE.h.llhG+..GIuF..p..KKhG-h.l..sp...p..p..I..EK.hFh.lcscp..tt......................	0	79	152	209
+1450	PF00199	Catalase	catalase; 	Catalase	Finn RD	anon	Prosite	Domain	\N	19.60	19.60	19.80	19.60	19.20	19.40	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-11.94	0.70	-5.78	121	5600	2009-01-15 18:05:59	2003-04-07 12:59:11	14	27	3265	302	1509	4794	143	346.50	44	69.89	CHANGED	TsstGssls.sspsohss....Gs...p.G.PhLLpDhpLl-cls+FsR.ERIPERsVHAKGsGAaGpFpso.s-.....hophTpAshhppsGp....cTPlhsRFSTVuGppGSsDss..RDsRGFAlKFYTc-GN.aDlVGNNhPV.FFlRDshKFPchl..HutK.pPposh....pcssth........................aDFhutpPEuh.Htlthlhoc.+GhP..toaRphsGaGsHTaphlN.spGctt...aVKaHacsppGhcslsscEAtp.htupssDatpcDLapsI.cpGsaPpWplhlQlhs.p-spph....p.as.hDsTKlWPcpchPl.......hplGphsLN.+NPsN.aFu-sEQsAFsPusl.VP.......GIphSsD.hLQuR.hFuYsDop+aRLG.sNa.plPlNt.P.......hs...h.s......pDG.hth............t.......ss..tssY.Psshssst	..............................................................................................................................................................................TpstGh.ls..s.s..psohps..........G....cG..PhLlpDhhhhEc...........ls+F.......s+..E+IPE..R..hVH.A+G.u.G.A.a..GhFpsp..ps.........l..o.chTp.....Aphhpp..Gc..............pTPlhlRF.S.TV...............sGpp.....G.....os..Dsh...RDs.RGFA.......lKF..............Y...........T............-..E....G...........N...a...........DLVGNNh.................P.l.FFl+Dsh...KF................P...Dhl..................Hu....K..pPcspl......pststh..............................WD.....F...ho..h..p...PEuh....Ht.....lhh...lhS...D....RGlP........toa....R.p.M.pGa.G..s..HT..aphl.....N.....s........p................G.cth......aV.KF.Ha............+..................s.......p.p........G....l..........c...s.....L...s..............-..........EAt.........c..........l.............t...........u......p.D...-.....atp+DLapAI....c...p.....G.s.aP.c.WplhlQlhs..c..-t..p..ph......p..as..s.hD..hT..K..lWP....cc...phP.l....................h.VGchs.....L......N....RN....P....c....N...aFu....E....s....E....Q....s....AF.......sP...upl...VP.......G.lp.hSsD....hL.......Q.uR.lFuYsDspt.hRLG..sNa..plPlNp.P.....................tss...hts.p...+DG.hph.......t........ts.....tssY.Psphs...t.............................................................................................................................................................	0	417	840	1230
+1451	PF00666	Cathelicidins		Cathelicidin	Bateman A	anon	Pfam-B_276 (release 2.1)	Family	A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.	20.70	20.70	20.80	20.70	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.15	0.72	-3.82	8	193	2012-10-01 19:28:07	2003-04-07 12:59:11	12	2	56	5	87	189	1	65.00	50	41.10	CHANGED	sLSYREAVLRAVDphNEpSSEANLYRLLELDPs.PpsDpDPsTPKPVSFRVKETVCPRTopQsPEQCD	............LSYcEAVlR.....AVDphNp+Ss-.sNLYRLL..-L.D.......P...P.............ptD.tcssos.KPVSFTVK....ETVCP+o...s.p..ps..sE..pCD................	0	1	1	18
+1452	PF04731	Caudal_act		Caudal like protein activation region	Kerrison ND	anon	DOMO:DM04892;	Family	This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family.  This region is thought to mediate transcription activation.  The level of activation caused by mouse Cdx2  (Swiss:P43241) is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway [1].  Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (Pfam:PF00046).	22.40	22.40	22.40	25.60	21.60	22.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.21	0.71	-3.88	14	144	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	47	0	59	120	0	127.30	37	51.59	CHANGED	MY.PuslRps.GlN.............LssQNF.....Vuu.PQYsDYsuYHH..VPsh....Dsps.pPsuuWussYusP.REDW.ssYususussush.s.......SP.uphua.sss-Ysshps..............susGlL.........ssssuustthSPuup...R+ssYEWMRKolts....susup	.......................MY.Pus...lRps.uls.....................Lss.QN.a......sus.PQYsDasGYHH..hssh......-stt...tss....suWsusYusP.....REDW.ssYu.usssss.s..............os..u.hua.sss-asshts...............susGl.L..........ss.ssss.tt.SPss.p...R+s.apWMR+sstss.ss.t.........................................................................	0	3	8	22
+1453	PF00689	Cation_ATPase_C	Na_K_ATPase_C;	Cation transporting ATPase, C-terminus	Bateman A, Griffiths-Jones SR	anon	Pfam-B_137 (release 2.1)	Family	Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.20	0.71	-4.75	141	8688	2009-09-12 06:26:15	2003-04-07 12:59:11	16	115	3188	71	3253	7683	303	180.00	22	19.21	CHANGED	shPlsslQlLalNLlsDshs.uluLuh-ss.-...pslMp+..Pc.t.ppslhstthhhpl.hhhGhhhuhhslh...sahhshh.............................................h.......shs...........................................................upThsFssllhsplhp.shssRo.....tt..............shht.hshh..pN..hh.....lhhuhhhsl.hltlhlhah..P.........lpph.F.pss....sl.......................shtpW.........hhs.....lshuhhhhhh..sElh....Khl	.............................................................................................................PLtslQlLal........NLlhDs.hsulALuh.....-..s...s.....-.................pc.lM..p..+....P....R...t.p.p.......s....l.......h......st.t....h.....htph...lhh..G..hh..u......hhs.hh...........s.a.h...hhhh......................................................................................................................................hh............shs...............................................................................................................spThhFss...h.lhs.Q...hhp..sh.ssRo..........pp...........................................shh.........hshh..............pN...hh..............lhhulh.hs.....h..hlt............h.hlhah.....P..........................hs.ph..F..pht.....sL............................s.h.tpW.........hhs..lshuhhhhhl...splhKh...........................................................................................................................................................	0	1051	1898	2639
+1454	PF03310	Cauli_DNA-bind		Caulimovirus DNA-binding protein	Mifsud W	anon	Pfam-B_3746 (release 6.5)	Family	\N	21.00	21.00	21.00	22.90	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.59	0.71	-4.26	3	30	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	18	8	1	30	0	102.50	43	89.24	CHANGED	LAsItSEIcEllosQKohcu-IKAILE+lGSssP.pouLEoVAAKIIsDLTKcIc-CcCNKEIlEhLspp...DcQIIPoPcEc..tKtLuLsKYSYPNasVGNEELGSSGNPNALKWP.hctPps	..........hsph.KElu.cllos.Kshcs-IKAI...L-hluSps.s......p-sLEslAAKIlpD...lschIscC.CsKcll-tLtst......cppl...p.pct.......tpthshtK....YSaPNasVGNtpLGSStsPpALpWP.......s.....................	0	0	1	1
+1455	PF03233	Cauli_AT	Caulimo_AT; 	Aphid transmission protein	Bateman A	anon	Pfam-B_3118 (release 6.5)	Family	This protein is found in various caulimoviruses. It codes for an 18 kDa protein (PII), which is dispensable for infection but which is required for aphid transmission of the virus [2]. This protein interacts with the PIII protein [1].	21.10	21.10	21.20	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.14	0.71	-4.53	6	35	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	22	0	3	37	2	136.50	49	73.75	CHANGED	MS.shos.PHIYKK.-pllRLKPLs.lsSNsRpYhFSS..pKusIpuIhsHCNNLNpIVuRsaLtlsKl.SYFGLpKDsSEthSKsKsP..shFsshppIF+cGGsspcppsp.lcoLpEhpN......RItclpppsKcLs-p.l.scsLhKc.VKDhcEpLscIc-ulKsIIG	.......................MS..lTupPHlYKK.-pIl+LKPLs.lsSNsRpYhFuS..sKusIpsIlsHhNNLNpIlGRshLtlhKlsSYFGLp........KDsSE............SKSKsP..SVF.ssucsIFKsGGsDh.ssphc.plcsLhEhpN........+IcpL-pthppLspc.I.scs.hcp.lK-hccplppIc-tlKsIIG............	1	0	0	2
+1457	PF01693	Cauli_VI	Caulimo_VI;	Caulimovirus viroplasmin	Bashton M, Bateman A	anon	Pfam-B_1373 (release 4.1)	Family	This family consists of various caulimovirus viroplasmin proteins.  The viroplasmin protein is encoded by gene VI and is the main component of viral inclusion bodies or viroplasms [2]. Inclusions are the site of viral assembly, DNA synthesis and accumulation [2]. Two domains exist within gene VI corresponding approximately to the 5' third and middle third of gene VI, these influence systemic infection in a light-dependent manner [1].	19.90	19.90	19.90	20.00	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-7.98	0.72	-3.93	212	1222	2009-01-15 18:05:59	2003-04-07 12:59:11	11	36	808	7	520	1128	69	43.80	36	16.86	CHANGED	Ka..YuVtpG+p..s.........GlY.soW...s-scpp......VsGasuAp..aKuF.sohpEApta	.....................a..YuVt..pG+p..s............Gla..soW....s-Cppp........VpGasuAp......aKsF.sohpEApta......................	0	188	333	458
+1458	PF04771	CAV_VP3		Chicken anaemia virus VP-3 protein	Kerrison ND	anon	Pfam-B_2147 (release 7.6)	Family	This protein is found in the nucleus of infected cells and may act as a transcriptional regulator.  It induces apoptosis, and is also known as apoptin [SwissProt annotation for Swiss:P54094].	25.00	25.00	25.10	41.20	24.70	18.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.63	0.71	-4.14	7	93	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	0	0	63	0	108.30	94	99.84	CHANGED	MNALQEDTPPGPSTVFRPPTSSRPLETPHCREIRIGIAGITITLSLCGCANARAPTLRSATADNSESTGFKNVPDLRTDQPKPPSKKRSCDPSEYRVSELKESLITTTPSRPRTARRpIRL	.............MNALQEDTPPGPSTVFRPPTSSR.PLETPHCREIRIGIAGITITLSLCGCANARAPTLRSATADNSESTGFKNVPDLRTDQPKPP.SKKRSCDPSEYRVSELKESLITTTPSRPRTARRCIRL.............	0	0	0	0
+1459	PF01146	Caveolin		Caveolin	Finn RD, Bateman A	anon	Prosite	Family	All three known Caveolin forms have the FEDVIAEP caveolin 'signature motif' within their hydrophilic N-terminal domain. Caveolin 2 (Cav-2) is co-localised and co-expressed with Cav-1/VIP21, forms heterodimers with it and needs Cav-1 for proper membrane localisation. Cav-3 has greater protein sequence similarity to Cav-1 than to Cav-2. Cellular processes caveolins are involved in include vesicular transport, cholesterol homeostasis, signal transduction, and tumour suppression [1].	25.00	25.00	25.60	25.60	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.88	0.71	-4.62	21	305	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	100	0	153	266	0	143.40	45	85.68	CHANGED	sc-ph...........................sctps...h..........p-.cptthshssRDP+plNsc.lKlsFEDVIAEP.suoHSFDtVWhsSassFploKYhhYRlLosLLulPlAhlhGllFAlLSslHIWhVsPhl+ohLh.lsslpplWs.shcshhsPlFpuhG+hhSulplplpcp	...................................................s......p.pt...h.hDscpt.thshssRDP+plNsc.lKlsFEDVIAEP.puTHSFDslWpsSassFploKYahYRlLoslhuIPhAllaGIhFAhLSFlHIW......hVsPslKohLI.t...lpslpplashhlcsh..ssPLFpulG+hFSslplphp+.-......	0	40	53	98
+1460	PF02275	CBAH		Linear amide C-N hydrolases, choloylglycine hydrolase family	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_5806 (release 5.2)	Domain	This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides.  These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, Pfam:PF15508.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.94	0.70	-5.00	8	2070	2012-10-03 21:14:07	2003-04-07 12:59:11	13	9	1418	42	386	1606	83	285.70	24	86.92	CHANGED	CTulshcspcsphlaGRNMDas......hshsppVI...lhPRsaslsh.cp.ss.hss+h..............AhlG.MGshhtshP.lasDulNE+GLuhAGLYa..ssaspap+ssccspssIssh.lhpaVLsNsoSV-EVKctLpphslVs.....sl..slh.hs.sLHahlsDtSGEulVI.EssK-.uLcVa-s.phGVhTNsPsa.cWal..TNLspYpulp.p..pshhhschclssaupGhGtlGLPGDhTPusRFlRsuahKtsh.cspsEstulsshFcILuossh.+GsVls.psp.chTlYToshssspGpYYachY-s.plptlsL.ccsL..............Dss-.hoa	..................................................................................CTuls.h..s..t.......p..s....p.hhhGRohD.at...........h.s..h.ss..p.lh.........lh.P..+...s.....h...p....h....st........p....t......s......s......p..........h......p..t..ph..........................uh.lG...h..u..h..s...........h...t.........s.h.......h.........h....s..D.G....hNEcGLu..h..ut..hah...........ss..h..up.a..t..p...t............p...t.....s.....p......s.....ls.....shph.l....palLsphsoVpEsc.pt.l..p.....p...h..p..l..ls...............................th.......st..h......s..........h..s...s.l.....H.ahlsD.tsGcolll.E..h..ps....t..........l.p.l........a............-s...........ht..Vh..TN...sPs.a..s.hph..tNL..p.pYh.hp.........................t..s.........h......s.s...........h......p.........h.................s.....t..t...Gh.h...s....L.P.G.s.hosssRFlRss.......a.h............p.......ts.............h...s.............p.............s................s............s............p............p............pu.l....sphapllpsssh...P.......h.......G....h......s.........h.........s.....t...........p........s..........p.......................p.......h.......Thaposhshppth.h.Yhcshts.p.l.htlphpp..........................h..........................................................................................................	0	137	230	310
+1461	PF03914	CBF		CBF/Mak21 family	Wood V, Griffiths-Jones SR	anon	Pfam-B_3822 (release 7.2)	Family	\N	20.50	20.50	23.40	22.80	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.16	0.71	-4.79	111	959	2009-01-15 18:05:59	2003-04-07 12:59:11	12	15	309	0	670	933	15	173.80	25	23.17	CHANGED	hsl.uL.hlh.t.lhpp....p.....slc........h.......scFYppLYphL..ssp...........................lhpss.+.pp.................................................hlpLLpphL..pssphsh..pplsAFlKRLhpl.ul.ptsssshsuhlhhltpLhpp...aP.shpsll.pspp.................t..................t...........t......................................................................................sYss......cc.....c-Pphs.s.A.po...sLWElphL.ppHaHPsVsphAp	.......................................................................................sl.uL.hlh.....lhpp....p...................sl-h.......scFYppLYphL..ssp...................................hhpsp.+.tp........................................................................................hhlplLpthL.............pssp....hsh.........tRlsAFlKRLhpl.uL.......pt....s...s.ss.......hhu.hLhhlppLhpp......aP...phpsl..l..cppp.pt..........t......................................................t................................................................................................................................sY..ss.................ppc-Pphs...s..A.po.......sLWElp........hL.p....p.H.aHPsVsphA......................................................................................................................................................................	0	233	374	558
+1462	PF02312	CBF_beta		Core binding factor beta subunit	Mian N, Bateman A	anon	Pfam-B_12381 (release 5.2)	Family	Core binding factor (CBF) is a heterodimeric transcription  factor essential for genetic regulation of hematopoiesis and  osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold [1].	25.00	25.00	27.50	27.40	24.10	23.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.99	0.71	-4.64	8	133	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	83	10	77	145	0	147.10	52	84.21	CHANGED	MPRVVPDQ+SKFEoDELFR+LSR-SEl+YTGYRDRutEERpsRFpNuCR-G+uEloFVAoGTNLpLpF.ssps.htp..............cc.lDFD+EhGKVHlKS.FIhNGVCVpa+GWlDLcRLDGhGslEaDEcRAppEDulh+csl-ptppRhpEFE-cpRta+csppsphpt......u.sl	.............................MPRVVPDQ+uKFEs-EhFR+LSREsEl+YTGaR-RshEER.phR.F.NsCR-...Gcs...El.uFVAo..GTNLpL.F.ssp..htp..............cc.sDF-+EtG.KVaL+ushIhNGVCVha+GWlDLpRLDGhGCLEaDEcRAtpEDAhh..ppth...-p.hppRhREFE-ppRsa+pp.ps..pt....t.sss...............................	0	20	25	56
+1463	PF02045	CBFB_NFYA		CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B	Mian N, Bateman A	anon	IPR001289	Family	\N	20.10	20.10	20.10	20.40	18.70	19.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.13	0.72	-3.43	25	558	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	271	0	319	542	1	56.50	67	18.95	CHANGED	--PlYVNAKQY+uIlRRRpuRAKhEt...pp+...................l.s+sRKPYLHESRHpHAh+RsRGsGGRF	.......EpPlYVNAKQ........YHtIL+RRpuRAKLEt...ptK.............................................l..s.KsRK......PYLHESRHpHAM+RsRGsGGRF.....................................	1	91	179	258
+1464	PF00808	CBFD_NFYB_HMF	Archael_histone; Arch_histone; 	Histone-like transcription factor (CBF/NF-Y) and archaeal histone	Bateman A	anon	Pfam-B_1351 (Rel 2.1) & Pfam-B_3673 (Rel 7.5) & Pfam-B_2078 (Rel 8.0)	Domain	This family includes archaebacterial histones and histone like transcription factors from eukaryotes.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.82	0.72	-3.91	28	2710	2012-10-10 12:36:46	2003-04-07 12:59:11	18	35	501	23	1800	5141	81	64.60	30	31.69	CHANGED	tpLPlAslp+IhKps..sst+..lup-ApchlscslpEFlphlsscAs.-hspcppRKTlps-DlthAl	................................h..LPhAp.lp+....I....h....K.....p.....s..........s....ssp............l..up....-Ah.h...l...............s.c.....ss..p.FIphlo...pc.........At....p...hs..p......p..p..p....R....K.......T.l..pspDlhhAh.....................	0	538	1012	1477
+1465	PF01656	CbiA	CBIA;	CobQ/CobB/MinD/ParA nucleotide binding domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_782 (release 4.1)	Domain	This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA Swiss:P29946 and CbiP Swiss:Q05597 from  S.typhimurium [4], and CobQ Swiss:Q52686 from R. capsulatus [3]. These amidases catalyse amidations to various side chains of  hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis  of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many  plants and animals and is primarily produced by bacteria [4]. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family [6].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null --hand HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.18	0.71	-4.90	79	20629	2012-10-05 12:31:08	2003-04-07 12:59:11	18	135	4514	62	5745	39422	11955	208.60	17	65.21	CHANGED	lslsutKGGsGKTThussLsthLup..tGh+VhshDh.Dspssssthhh...............................t.............h...htpshtsh.....................................thhsh.hhhph...tthpt..h......................................hpthhpthhptt....aDhlllDsssulsph................hspslsssshlllshpsph..hu..ltuhtphhphhpph..............lhGlllN+ht.s..pthtp.hh.thh.h.hhh....hh.........thhscshtlsp	..............................................................................................................................................lslsstKGGV..GKTT....s.......s..........s.s....L....u.......t.......s.L...........u..............p........p............G..........h...........+............V........l...l.......l........D.....h.....D....s.....p....s....s..s...s...s..h.ht.h............................................................hh...................................................................................................................................................................................h.h.thp...................................................................h...l.p.p...h...l..p..p...hhptt.............aD..h....l..l..lD....s...s....s...u....l.s.th......................................................................................s.h.s.u....l...t.....s.....u......c..........h..........l.......l........l...s...h...p....sph.........hu............lp.u....h.....t..p....l.....h.....p....h...l...p...p.ht..................................h.h.h.s..l..l..h..s.h...h..t....t........pth..t..h......t.......h............................................................................................................................................................................................................................................................................................	0	1917	3836	4923
+1466	PF02570	CbiC		Precorrin-8X methylmutase	Bashton M, Bateman A	anon	COGs	Family	This is a family Precorrin-8X methylmutases also known as Precorrin  isomerase, CbiC/CobH,  EC:5.4.1.2.  This enzyme catalyses the reaction: Precorrin-8X <=> hydrogenobyrinate.  This enzyme is part of the Cobalamin (vitamin B12) biosynthetic pathway and catalyses a methyl rearrangement  [1,2].	21.30	21.30	23.90	29.00	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.14	0.71	-4.89	155	1640	2009-09-11 02:55:36	2003-04-07 12:59:11	10	16	1546	15	459	1277	315	196.50	41	85.28	CHANGED	sIh.pcSFthIcpEhs.....p..thsstp..tpllpRhIHuouDh-hsc..hlpFos....s..............ulpuuhsAL.psGu..sIlsDspMVtsGIspttL.t......ssplhChls-sclsphApptGtTRosAulchhtp..c.........hsuullsIGNAPTALhcLl-hl..cp..sts+PALlIGhPVGFVuAsESKctLtt........slPhIslcGR+GGSslAuAslNALlphsp	...................tI.ccSFtlIcsEhs........p.....th..s.sp.p..ptllhRhIHssuDh-.hs..c..pltFos....s..............slpsutpAL.....ps.Gu..........sI.lsDspMltsGIs+ptLs.t.......s.....sclhChlsDscVschAc.......p.tGhTRSsAAl.-lhtp...c...........hssu.lh.sIGNAPTALa+Ll-hl..c..p....s..s.s..c.PAhllGhPVGFVGAAESKct.Ltps.................slPalsspGR+GGSslAAAhlNALhh.....................	0	144	309	396
+1467	PF01888	CbiD		CbiD	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	CbiD is essential for cobalamin biosynthesis in both S. typhimurium and B. megaterium, no functional role has been ascribed to the protein. The CbiD protein has a putative S-AdoMet binding site. It is possible that CbiD might have the same role as CobF in undertaking the C-1 methylation and deacylation reactions required during the ring contraction process [1].	25.00	25.00	35.50	27.20	19.40	21.50	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.51	0.70	-5.42	6	1191	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	1139	1	338	1049	276	250.80	40	67.94	CHANGED	scph+pGYTTGosAoAAAhAAlhsLh.ucphcpVplpsPs.GhplplslEpsch.puppAhAslhK-uGs.DhDlTpGh.IhuEVphpsGp.-lhIpGGEGVGhVT+.Gl.V.hGEAAINssPR+hIccslpchls-...scGs.VsISlPcGEclApKThNs+LGIlGGISILGTTGIVpPhSscuacsSLs.plslAhApsac+llhssGspGp+aARchh.slsp-thlphuNFhGahl-cAtcpGsccIlLlGasGKLIKlAuG	..................................s...LRpGaTTGoCAsAAu+AA...hhhL....l....p.......t...p...............h..........c...p..Vp.ls..hP......p...G...........p.......lphs...l...........pp...........hph......p........s...............s..........t..........A......t...........A..ulhKDuGD.D.PDlT+GhhI..hu.....pV............p...............h...............................s.............s.........t..................s...........t.............l..............h................lpu..GpGVGpVT+...GLsls.l....G.csAINPsPRcMIp...p...s...l...p...c...h...h...s..t..........................stu....hpl..pIslPpGEclAp+ThNsRLGIlGGISILGTTGIVpP.h.Spp....Aa.hpSlpht...l..c..l..t.....p.A.p.G..h.....p.p..llhssGstuEchsp....p...........h.........h......s....l...........sp.psllphusFlGhhLc...t...st......c........h......s............hp......c......lhlsG.th.GKlsKlAuG.............................	0	118	232	295
+1468	PF01890	CbiG_C	CbiG; 	Cobalamin synthesis G C-terminus	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Members of this family are involved in cobalamin synthesis.  The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [1]. Within the cobalamin synthesis pathway CbiG catalyses the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B [2]. This family is the C-terminal region, and the mid- and N-termival parts are conserved independently in other families.	21.20	21.20	21.20	23.40	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.28	0.71	-3.86	204	1400	2009-01-15 18:05:59	2003-04-07 12:59:11	11	24	1369	5	399	1196	300	120.40	30	34.00	CHANGED	slslGlGCc+ss..shppltpslppsLtp.......tslshpslsslAol-hKt-Es...ulhphApphs..hPlphassppLpt.t....hsss.SphVhpph.Gss..uVAEu.AALhuu............ssup.........LlltKpthss..............sTlAlAp	............................................................t.lslGlGC++s.s..shppltphlppsLpp............t.sl...s.tu.lps...luolclKtsEs...ullplApphs..........lP.hphass-pLpphp..........................h.ssSsh.Vt.cpl.Gss..uV.uEsAAlhss.............................s.sup..............................................LlspKhttss...............sThAlu................................................................	0	127	262	337
+1469	PF02571	CbiJ		Precorrin-6x reductase CbiJ/CobK	Bashton M, Bateman A	anon	COGs	Family	This family consists of Precorrin-6x reductase EC:1.3.1.54. This enzyme catalyses the reaction: precorrin-6Y + NADP(+)  <=> precorrin-6X + NADPH.  CbiJ and CobK both catalyse the reduction of macocycle in the colbalmin biosynthesis pathway [1,2].	28.60	28.60	29.00	31.70	27.50	28.50	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.62	0.70	-5.05	90	1417	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	1368	0	341	1152	320	240.60	29	86.82	CHANGED	h+lLlLGGTsEAptLAptLssts..........lssshShAGRstp..Ps..sh.slRlGGFG.....GssGLssaL...cpptlshllDATHPFAuplSpNAspAspptGlPhltlcRPsWp.ts.......sDp.WhpVsshspAsphL..........h...s.pR.VFLslGRppLstF......tthsppphllRsl-ssps.....slsh.ssspllhsRGPFshp........sEpuLhcpapI-slVoKNSGGs.ustsKlpAARpLGlsVlhlcRP.slP.sstt....hsssscslsalt.ph	..........................plLlLGGTs-uptluptLstts.............lsssoshuuchtt.........st.....ss...tl.+sGsh.......shcsltpal.....cc.p...pl..c..hllDATHPaAsplSpsA.h........pA.................s...c...........ps.....s...........lPhlRhcRs...sh..t....t.............................scs..hhhVsshppAsphh..................ph.......s.pp...lhLTsGppsLsta.........thsppphlsRslssscs......plsh..stt..cllsh+GPF..oh-..............hptslhcp..h....phc...........slVoKsSGus.uhptKlpAAtchGl.sVlhlpRP...sls......s..t.ph.....hpshsphhphl..t....................	0	105	223	288
+1470	PF01891	CbiM		Cobalt uptake substrate-specific transmembrane region	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of proteins forms part of the cobalt-transport complex in prokaryotes, CbiMNQO. CbiMNQO and NikMNQO are the most widespread groups of microbial transporters for cobalt and nickel ions and are unusual uptake systems as they consist of eg two transmembrane components (CbiM and CbiQ), a small membrane-bound component (CbiN) and an ATP-binding protein (CbiO) but no extracytoplasmic solute-binding protein. Similar components constitute the nickel transporters with some variability in the small membrane-bound component, either NikN or NikL, which are not similar to CbiN at the sequence level. CbiM is the substrate-specific component of the complex and is a seven-transmembrane protein [2]. The CbiMNQO and NikMNQO systems form part of the coenzyme B12 biosynthesis pathway [3]. The NikM protein is Pfam:PF10670.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.60	0.71	-4.72	154	1775	2012-10-03 02:46:00	2003-04-07 12:59:11	11	5	1495	0	550	1442	303	202.70	27	84.38	CHANGED	HIsDGhL.ssshssshhslusshlshuh.....++lcpp......t...lPh.........................lul.huAhhFssphlslPl..su..oosHhlGsuLhulllG.sasuhlshslsLllQAllFucGGlssLGsNshsMulsus.hsua.hhhp..................l.......hph.........................thhluuhl....u...uhlulhhuulhsultLuls.s..............................................shthshshhh.......hsalsl.ull.EGllTshllshlt..+hcPch	......................................HI.-GhLss.hshshh..s..h.s..hshlsh.ul.......h+lppp....hp....ppp.........hsh.........................hul......s..uA......hh...Flh..p..h...l..pl...Pss..sG.....ossHh....h..G....s..uLsull....hG..shssslh.hs...l..l.Llh.QA....L....L.h..u..c.G....G..l..s...s...LGs.Nshs..Mul.h.ushlua..hla+..h......lpch....................thphhlusFl......u....uhl..us.h.h.s.h.h....s....s....u...l...p.L.ulu..hs...t.........................................hshhthhsh.hh....hsplsl..uls.EGllTshlhshlt.pht...................................................................	0	185	372	476
+1471	PF02553	CbiN		Cobalt transport protein component CbiN	Bashton M, Bateman A	anon	COGs	Family	CbiN is part of the active cobalt transport system involved in  uptake of cobalt in to the cell involved with cobalamin biosynthesis (vitamin B12).  It has been suggested that CbiN may function as the periplasmic binding protein component of the active cobalt transport  system [1].	25.00	25.00	32.70	32.30	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.61	0.72	-3.98	12	603	2009-09-12 00:29:08	2003-04-07 12:59:11	10	1	593	0	137	328	12	71.60	44	67.62	CHANGED	hpplllLlh.hhlhllsLll....h.hpcts.hG.uDspAEcsIpc.lsstYcPWFpPlaEPPSGElESLLFuLQAA	........h..phllllh..sl.h.lhllsLll.......h.....hh....s...c.sut..aGGoDspAEptIpp.l.s.spYcP...WFpP...l...a......E.....P.....s.....SGEIESLLFsLQu..	0	47	99	122
+1472	PF02361	CbiQ		Cobalt transport protein	Bashton M, Bateman A	anon	Pfam-B_673 (release 5.2)	Family	This family consists of various cobalt transport proteins Most of which are found in Cobalamin (Vitamin B12) biosynthesis operons.  In Salmonella the cbiN cbiQ (product CbiQ in this family) and cbiO are likely to form an active cobalt transport system [1].	21.40	21.40	21.50	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.53	0.70	-4.79	21	6688	2009-09-20 21:39:57	2003-04-07 12:59:11	11	12	2806	0	1371	4611	488	211.40	20	79.22	CHANGED	tsshlHclsschKLlhhhhhllhssls.shhsh.llhsllhhshhlsths......phhtphhhh.hlhhlhshlhlhh.................................th.sthlhssss.......................................................h.lhp.G..............................hhtulhlshRhhshlhshhh....LshTTsh.ElssulcclthPh.........lshhhhLuhRal.hlhcEhpplhpAppsRshph...p.shtpthpplshLlsshhlp.uhc+uEclshAMpuRGYss...tpsph	...............................................................................................t....hpplss.t.sK.l.h.h.h..h..h..h..h..h..h...h..h..h....s..........s...h...........h..h...h..h..h..h..h...h..h.h..h..h...h..h..h.h..s.th....................h..h.h...h..h.h..h..h....h...h..h...h..h.l..h..h..hh.hhhh...............................................................h....t..t..t...t..h..l...h..t..h.hh...........................................................................................................h....l..t.t.t.u........................................lhh.u......h..h.l...h.h.....R.h.h.s..h.....lh.hs.hl................hsh...TTss.sp.l.h.s....u.......l.p.p.l..h..hPh.............................................................cluhhlslslRalPhlhc-hppIt.pApcsR...Gh..ph..........t...t......s....h......h..........p....p......h.....+.......s...h...h..........l....l....h.PL...h.hp....uhc+u-plutAM-sRG..aps.........h................................................................................	2	510	954	1206
+1473	PF01903	CbiX		CbiX	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of CbiX is uncertain, however it is found in cobalamin biosynthesis operons and so may have a related function. Some CbiX proteins contain a striking histidine-rich region at their C-terminus, which suggests that it might be involved in metal chelation [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.11	0.72	-3.92	76	2846	2012-10-01 23:23:09	2003-04-07 12:59:11	12	22	1311	18	915	2680	601	103.40	22	64.24	CHANGED	HGS.+c.scuspshtphs.phltcths..h.V.phuFl-hsp.Pslppul....p.plhtt.....Gsccl.......lllPhhL.hsG.hHscpcI......sp.......lp.....phptphs........................thp..l..hhupsLGscstlhplltp	.................................................+Go.pc....sp....us...t..th....p....ph....s..p....tlt....p..........p.........h..........s.....h...................V..........c....h..........uF...l...........p........hsp....P...s...lppsl................p.ph.htp...............Gsp.c.l.......................lll..Ph.h.....L.hsG.hHh..c..c..cI.........st.......lp.........php.t.phs.............................................................h.p.h.thu...s.sL.....Gs..cstlhphl..t...............................................................	0	286	665	834
+1474	PF02262	Cbl_N		CBL proto-oncogene N-terminal domain 1	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3949 (release 5.2)	Domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.	25.00	25.00	25.10	25.80	20.10	24.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.68	0.71	-4.43	3	228	2009-09-10 23:26:51	2003-04-07 12:59:11	11	12	88	35	117	222	0	122.10	60	17.48	CHANGED	.suosDKKhLEKsWKLMDKVVKLCQsPKLNLKNSPPFILDILPDTYQHLRLIaS+NEDpMclLp-NEYF+VFlENLM+KCKQsIKLFKEGKE+MY-ENSc.RRNLTKLSLlFSHMLuELKAIFPsGlFtG	..............ssD++sl-KsWKLMDKVV+LCQsPKLsLKNSPPYILDlLPDTYQHLRhI......h.S.+Y........-.....s......+....h.....t.....t.....L....u....-.....NEYF+lal-NLh+KoKpsIpLF.....KEGK.E+MY..-EpSp.RRNLTKLSLIFSHMLAELKAIFPs..GhFpG....................	0	24	34	66
+1475	PF02761	Cbl_N2		CBL proto-oncogene N-terminus, EF hand-like domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3949 (release 5.2)	Domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.	20.00	20.00	20.30	20.80	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.00	0.72	-3.91	5	227	2009-01-15 18:05:59	2003-04-07 12:59:11	9	15	92	35	122	226	0	81.50	68	11.39	CHANGED	pFRlTKA-AcpFWRcpFGsRslVPWupFcotLspsHPlosG.hEAhALKoTIDLTCNDaISlFEFDVFTRLFQPWsTLLRNWQlLA	......................FRITKADAA-FWRctFG...c+....TI.VPWKhFRQsL+cVHsISSG...LEA.MALKSTIDLTCNDYISlFEFDIFTRLFQPWuoLLRNWphLA..............	0	28	39	74
+1476	PF02762	Cbl_N3		CBL proto-oncogene N-terminus, SH2-like domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3949 (release 5.2)	Domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.	25.00	25.00	39.70	38.00	20.10	18.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.87	0.72	-4.35	4	215	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	85	35	115	217	0	84.00	81	11.55	CHANGED	sHPGYhAFLTYDEVKtRLQ+hhcKPGSYIFRLSCTRLGQWAIGYVouDGpILQTIPpNKsLhQALl-Ga+EGFYLYPDG+spNPDL	........THPGYMAFLTYDEVKARLQK.a.hpKP..GSYIFRLSCTRLGQWAIGYVTuDGsILQTIPHNKPLFQALIDG.REGFYLaPDGRshNPDL..........	0	24	34	64
+1477	PF00734	CBM_1	CBD_fungal; CBD_1; 	Fungal cellulose binding domain	Bateman A	anon	Pfam-B_444 (release 2.1)	Domain	\N	20.60	20.60	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.57	0.72	-4.28	133	1334	2010-01-08 14:00:54	2003-04-07 12:59:11	13	104	175	6	936	1332	9	28.80	51	7.32	CHANGED	tau.QCGG...G..a.oGsTs..CsuGhsC..pthNsaY	......haG.QCGG..tG.......a..oGsTs...Cs.....u..G..h....o..C..ph.Ns.aY.........	0	387	592	830
+1478	PF02013	CBM_10	CBD_5; 	Cellulose or protein binding domain	Bateman A	anon	PSI-BLAST P10476/668-713	Domain	This domain is found in two distinct sets of proteins with different functions. Those found in aerobic bacteria bind cellulose (or other carbohydrates); but in anaerobic fungi they are protein binding domains, referred to as dockerin domains or docking domains. They are believed to be responsible for the assembly of a multiprotein cellulase/hemicellulase complex, similar to the cellulosome found in certain anaerobic bacteria.	21.00	21.00	22.00	23.20	19.50	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.07	0.72	-3.69	92	276	2010-01-08 15:14:06	2003-04-07 12:59:11	11	56	49	10	58	278	0	34.80	41	10.69	CHANGED	s..Chspthu..YsCCss...s.tlhasDssGsWGlENs.pWCul	.........C.sttpu..YPCCss...s..s.hsDssGsWGh..ENs..p.Csh..	0	16	54	58
+1479	PF03425	CBM_11		Carbohydrate binding domain (family 11)	Bateman A	anon	CAZY	Family	\N	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.16	0.71	-4.58	15	149	2012-10-03 19:46:52	2003-04-07 12:59:11	8	40	89	1	61	228	302	177.60	16	25.80	CHANGED	suhshhl-DFEss.s.s..hh.hWto.ssssspsuoplss.....stsscuhplphs..sstuuashpVsasl-cu.......Das......................pauGlsF.h.......K...Guu+plc....lEIsDss......cs-lalsslssspo.WpplpIsFsshsp......sGhstcssh...DLccltu.lsFpspussu....ssapIDslcLh....stspspssps	...........................................................................................s......lDc...F-.....sh.........s............s........h..h....ahs...s.s.pssthphp.ts................stssps.....hp.hphs....sstsshh...ssh...ths..hs.tt................................DWS..................................................shs.ul.pF.hl.........+ss..Guuppls.........l.....pl..p.sss..................t..c.hah......t..p..hss....sts..Wp.plpIPFsshst.....s..ss...st...st...s...h.....clspltt...hsh...h.hssstt...........sph..h..lDslphh..............s.....................................................................................	0	38	47	54
+1480	PF03426	CBM_15		Carbohydrate binding domain (family 15)	Bateman A	anon	CAZY	Domain	\N	20.30	20.30	20.30	292.50	20.20	17.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.03	0.71	-4.87	2	3	2012-10-03 19:46:52	2003-04-07 12:59:11	9	1	3	3	1	7	0	160.30	69	26.24	CHANGED	lplDMssGWRGNuoG...pSGlThsuDGVoFsA.GDslGAVhDhh+PhpLEDAlIsMVVNVSuEFKAStAsLQ.hsQlKts...GEWsChAusp.hTAspDhTloCTlsEsDcKFNQTthDVQVGlQAKGTPsGslTIKSVTlTLA.tA.............YSAN	IEVDMANGWRGNASGSTSHSGITYSADGVTFAALGDGVGAVFDIARPTTLEDAVIAMVVNVSAEFKASEANLQIFAQLKEDWSKGEWDCLAASSELTADTDLTLTCTIDEDDDKFNQTARDVQVGIQAKGTPAGTITIKSVTITLAQEAYSAN.............VDHLRD	0	1	1	1
+1481	PF03424	CBM_17_28	CBM_28;	Carbohydrate binding domain (family 17/28)	Bateman A	anon	CAZY	Domain	\N	25.00	25.00	37.00	31.20	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.32	0.71	-4.67	7	48	2012-10-03 19:46:52	2003-04-07 12:59:11	9	6	27	11	12	57	0	188.40	35	39.07	CHANGED	VWu.EELSlSGEYVRARIKGhpYpP......I-RT...caocslWD..FNDGTpQGFslNuDSP.hpslslENsN..sAL+IoGLNs..SNDlo..EGNaWANVR..lSADt...WupshsIhGApcLTMDVIscpPsTVuIAAIPQSsstsWANPsRulpVp..ssFhppcDtpYKAhLTITstDuPslpsIApcscssshsNIILFVGo-s...uDVI.LDNIpVo	................Ws.ppLohSGpYsRuRIhG..Yts............p......hsphlhs..FpDGT+QGashsu-Ss.spss..lTIcssN...u.phhuhcs..spshs...sshWAs...A.....l.t-h....pups..lhhs.hLs...-hhscushslslAh.P.o.huh..WApsscshpls..schsp...tp..c..sp.chhhhhsh.D.splpshth.ssDohLpNlllhlussp...ustlalDNl+h............................................................	0	5	11	11
+1482	PF03427	CBM_19		Carbohydrate binding domain (family 19)	Bateman A	anon	CAZY	Domain	\N	20.10	20.10	20.10	20.10	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.14	0.72	-4.19	2	39	2012-10-01 20:20:38	2003-04-07 12:59:11	8	5	31	0	26	42	0	63.00	34	12.39	CHANGED	hTTTuhsTAoSA.hsh.hAspSCSoQsphuCTusGpYslCsaGKWVsusCPsGslClsosp	.........................................t.......................................hsGp..ossopGphACou.sGp...aAlCs.aG.sW.VhtpCsu.GTsCh....s...	0	8	15	24
+1483	PF00553	CBM_2	CBD_1; CBD_2; 	Cellulose binding domain	Bateman A	anon	SCOP	Domain	Two tryptophan residues are involved in cellulose binding. Cellulose binding domain found in bacteria.	21.10	21.10	21.10	21.10	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.07	0.72	-10.63	0.72	-3.96	17	1472	2012-10-01 21:34:18	2003-04-07 12:59:11	14	210	411	18	667	1442	50	96.90	30	17.38	CHANGED	spssYslsspWssGFsAslslpNsuosslssWolsash.s.GpplTpuWNAslosoGsshososhuWNuolss.....GuossFGFpGotsGus..sss.slsGss.C	.........................pssasssssW....s..u.....G......a.s.u....p....lslsNsGs.s.sl....s.u.W.slsash...sss..pp....lo..ss.....W......s..u..s.....h.......o.....p....o.......G.....s...p.h...o.ss..s.....s..u..a.....Nu....s.lus.....G.u.o.s...o..h...GFp.u.s.t..s.u..s.........ss.............................................	1	261	536	651
+1484	PF00686	CBM_20	CBD_2; CBD_4; 	Starch binding domain	Bateman A	anon	Pfam-B_111 (release 2.1)	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.41	0.72	-4.38	101	1301	2012-10-02 20:10:03	2003-04-07 12:59:11	14	99	591	106	739	1353	50	93.70	23	15.09	CHANGED	plsV.sFps.ps.....sTshGpslallGslspLGsWss.spAlsLshst....ssshPhWps..sl.sLPs.Gs....shEYKal+.....t.ssss...sV.tWEu..u.sNRshosPsssssssss	........................l.pFpl..ph.....psthG......p.plhl.....sGs..hspLG....s...W.s..s.......p.p.AltLpht..................t..s.hWps.....sl...sl......ss...sp.................slc..YKalh.................h..sss.s......sh...hW.Es...s..sN...R.hthst.......sh..................................................	0	308	491	631
+1485	PF03370	CBM_21	PRS; 	Putative phosphatase regulatory subunit	Mifsud W	anon	Pfam-B_2433 (release 6.6)	Family	This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein Swiss:O08541 has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localises it to glycogen.  Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.	21.10	21.10	21.20	21.30	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.67	0.71	-4.10	75	714	2010-01-08 15:58:43	2003-04-07 12:59:11	8	10	243	8	460	671	6	108.30	31	22.53	CHANGED	phppp.VpL...Eshtls.......ppslhGsltVpNluF-KpVtlRaT..hDsWcohp-lsupYhs...shtthsh....D..........................pFpFplsLsshht..........................................tpplpFClpY..pss.u....ppaWDNN.supNYplp	................................................t..ttp.VpLEph.hp.........ppslhGslpVpN.luF-K....pVtlRhT..h.DsWcohp.-ls..u.pYhp............sss..shD...........................................pFsFplslssh.h...............................................................ttplcFslpY.......ps.s..u........ppaWDNNsGpNYpl...............................	0	122	198	331
+1486	PF03423	CBM_25		Carbohydrate binding domain (family 25)	Bateman A	anon	CAZY	Domain	\N	26.80	26.80	27.00	27.20	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.00	0.72	-3.90	30	440	2010-01-08 16:02:45	2003-04-07 12:59:11	8	47	133	10	176	429	14	84.90	26	18.88	CHANGED	usslclaYNhssssLstpsclah+GuaNsWsps.uhs.chsc...t......usahpssl.plPppAhhlDaVFssG....sssYDNNsspDaphsls	...........................................sslslaYs......t....p..ps.h..s.t.psp...l..........ah+s.u...a...s....s...W...s....ps.......u..hs.p....ttp.................ssahpss.l.plPtp.Ah.t.l-alFssG.....ussa...DN...Ns...sp...Daphsl.s.............	0	61	121	159
+1487	PF02839	CBM_5_12	CBD_7; CBM_5; 	Carbohydrate binding domain	Bateman A	anon	Bateman A	Family	This short domain is found in many different glycosyl hydrolase enzymes and is presumed to have a carbohydrate binding function. The domain has six aromatic groups that may be important for binding.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-7.97	0.72	-4.37	135	2927	2012-10-03 03:17:01	2003-04-07 12:59:11	9	197	1085	40	615	2508	403	42.20	30	7.84	CHANGED	hssWsss.ps..Yss.G....-hVs.asG..phYpA.phasp.st...tsssst..........sW	...................ssWsus.ps...Yss.G......DpVs..a..p..G..psYpA..paWTp..us.........pPstss..........sW............................	0	203	349	497
+1488	PF04942	CC		CC domain	Bateman A	anon	Pfam-B_4563 (release 7.5)	Domain	This short domain contains four conserved cysteines that probably for two disulphide bonds. The domain is named after the characteristic CC motif.	20.60	20.60	20.70	20.60	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.04	0.72	-4.07	29	101	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	6	0	95	112	0	35.30	31	20.03	CHANGED	ssssshsCc..uss.....sPshs.GtCPsGhsllpushCCssc	..........tshsC+.......uss.....sPuls.GhCPsGhslltus.t.CCsp.t.....	1	41	43	95
+1489	PF01845	CcdB		CcdB protein	Bateman A	anon	[1]	Domain	\N	23.40	23.40	23.70	26.10	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.22	0.72	-4.09	12	537	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	413	26	75	272	31	98.20	43	98.60	CHANGED	hQFpVYpshucut...YPhllDVQSDlIsplsoRlVIPLhsscph.t.+ssp+LpPllp.l--psallhTppMASlPsslL.Gp.VsDLospRppI+sAlDFlhsGI	............MQFpVYps+tcsp...a.hhlDVQSDIIcshspRhVIPLsshchhsp...+ss..ccLhPllp.lsscsahlMTp-hAoVPlssl..Gcc..VsDlS.p.+cspIKsAlDhhhpGI..............	0	14	34	51
+1490	PF04995	CcmD		Heme exporter protein D (CcmD)	Bateman A	anon	COG3114	Family	The CcmD protein is part of a C-type cytochrome biogenesis operon [1].  The exact function of this protein is uncertain. It has been proposed that CcmC, CcmD and CcmE interact directly with each other, establishing a cytoplasm to periplasm haem delivery pathway for cytochrome c maturation [2]. This protein is found fused to CcmE in Swiss:P52224. These proteins contain a predicted transmembrane helix.	23.90	23.90	24.10	24.60	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.06	0.72	-4.23	96	1201	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1174	0	214	605	209	48.40	37	73.35	CHANGED	GsYuhYVWsuYulohlslshLlhholhpp+plhpclpctptRpt....ch	.....GGYAhaVWhAhuhTllsLslLllpolhp+RtlLptltp.ppAREs.R.h..................	0	45	106	160
+1491	PF03100	CcmE		CcmE	Mifsud W	anon	Pfam-B_2583 (release 6.4)	Family	CcmE is the product of one of a cluster of Ccm genes that are necessary for cytochrome c biosynthesis in eubacteria. Expression of these proteins is induced when the organisms are grown under anaerobic conditions with nitrate or nitrite as the final electron acceptor.	19.90	19.90	21.00	22.00	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.50	0.71	-4.58	135	1616	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	1542	4	402	1031	1646	131.90	46	83.52	CHANGED	h..st.+++RLhllshslsuluhAsuLlLhAhppslsaFaoPo-lhpscs........s.sspplRlGGhVppGSlpRs..suhpVp.FpV.TDs...s.........ss.lsVpYpGILPDLFREGQGlVApG................ph.tssG....sFtAsEVLAKHDEsYMPsE	...............................................................RR+pR..Lh.llhullsululssuLlLaAL.p.p.NIsh..F...YTPuEl.l.tGct..........t.sGpRlR.l.GG.M..Vh.....G.S......VpRss........soLc..Vs.Fsl.......t....Ds....t.........................s.s..V..sVsYcG..I..L.P.D.LFRE....GQGVVspG........................pL.tpss.....phhAcEVLAKHDE.sYhPPE..............	0	113	247	324
+1492	PF03918	CcmH		Cytochrome C biogenesis protein	Finn RD	anon	DOMO_DM01577	Family	Members of this family include NrfF, CcmH, CycL, Ccl2.	25.00	25.00	25.10	27.10	22.30	24.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.83	0.71	-5.21	177	2053	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1387	2	373	1270	1631	139.80	38	68.57	CHANGED	hlhhl..lhl..hh...................sh...sss.sDph.h...ss.....s.EpRhppLscpLRCsh.CQNpsIsDSsAslApDLRtpVh-hltpGcScppll-ahVsRYG-FVlacPshpstThlLWhuPhllLlh.GhhhlhhhhR++pttt..........................sLosp-p.....tcLppl.Lp	........................................................hhh...hh.lhL.hhs..................sut....tss.lDshpF..tss......tQcpphppLsppLRCPp..CQ.N..p..slsDS...N...A.l.AsD...hRppVYc.h.l.p.......EGKSc..pEIlcaMlsRYG.cFVpYsPP.....ls...st.TllLWhhPl......lhlllGuhll.h.tht.++pht...........................................t...........................................................................	0	93	206	291
+1493	PF03597	CcoS		Cytochrome oxidase maturation protein cbb3-type	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	23.00	23.00	23.40	23.40	22.50	22.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.99	0.72	-4.50	127	978	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	954	0	277	677	88	44.60	39	69.38	CHANGED	sllhlLIPlullluhlulhsFhWul+oGQaDDl-ssutRILhD.D-	................phlhhLIPlulllshlulssFlWul+oGQFDDl-t.uppI.LhD.D-.......	0	74	175	227
+1494	PF03150	CCP_MauG		Di-haem cytochrome c peroxidase	Mifsud W	anon	Pfam-B_3135 (release 6.5)	Family	This is a family of distinct cytochrome c peroxidases (CCPs) that contain two haem groups. Similar to other cytochrome c peroxidases, they reduce hydrogen peroxide to water using c-type haem as an oxidisable substrate. However, since they possess two, instead of one, haem prosthetic groups, bacterial CCPs reduce hydrogen peroxide without the need to generate semi-stable free radicals. The two haem groups have significantly different redox potentials. The high potential (+320 mV) haem feeds electrons from electron shuttle proteins to the low potential (-330 mV) haem, where peroxide is reduced (indeed, the low potential site is known as the peroxidatic site) [1]. The CCP protein itself is structured into two domains, each containing one c-type haem group, with a calcium-binding site at the domain interface. This family also includes MauG proteins, whose similarity to di-haem CCP was previously recognised [2].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.45	0.71	-3.93	173	2309	2012-10-03 10:02:11	2003-04-07 12:59:11	9	22	1444	47	631	1895	669	159.60	36	39.95	CHANGED	sttp.spLG+tLFaDspLSts.......sslSCAoCHs.ss..........t..uhsD..stsh.......u.hG.....hs.s.................ph.......ssR..NuPolhN.suap...............................................h.FW.DGRs...............................s..s..L.cpQA......htPl..tsshEM......ut...s........................hppll.p+Lps.............st......YtphFppsFs....................................sps........lshpplspAlAsF.p+ol...hossStFDpal.....pG.-tsAl	...................................s..p+stLG+tLaaD...sR.LSts.......ss.lSCuoCHs..hs.............t..uhsD......shps........................o..hG.......hs.s........................................................................................ph........GshNuPTlhN.usash.......................................................................s.FW.DG.RA...............................................................s.sL.p-Q.A......tGPl..hsPhEM.............us.......s................................................hctll.t+lpp................................st.......YtptFppsas..................................................ps....hshc.s.l.scAIApFE+TL...lossS.FDcaL.cG.-ppAh..........................................................................................................................	0	223	417	541
+1495	PF04505	Dispanin	CD225;	Interferon-induced transmembrane protein	Mifsud W	anon	Pfam-B_2070 (release 7.5)	Family	This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression [1].	27.10	27.10	27.30	27.40	26.70	27.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.79	0.72	-4.44	68	837	2009-09-11 14:57:37	2003-04-07 12:59:11	7	11	210	0	406	837	11	81.30	26	49.85	CHANGED	ss.usssh...............spsaLshuIhsol....hCsh....P...lGllAllaSspspsthttGDhsGAppsuppA+thslhuhlh....Gllhh..llh.l	...............................................................spD.a.ls..hulhssl...........hChh.......P.......lGllAhhaS.h..........cspsthhtGDhpuA.pphuppA+hhs....lhulhl.Glhhhlhh.h..........................	0	97	146	220
+1496	PF01130	CD36		CD36 family	Finn RD, Bateman A	anon	Pfam-B_1229 (release 3.0)	Family	The CD36 family is thought to be a novel class of scavenger  receptors.  There is also evidence suggesting a possible role in signal transduction. CD36 is involved in cell adhesion.	19.80	19.80	20.30	20.00	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.55	0.70	-6.19	52	1012	2009-01-15 18:05:59	2003-04-07 12:59:11	16	15	151	0	630	1015	58	355.90	22	82.78	CHANGED	hhsluhllhlhuhlhhhh.asshhpphlccplsLps...sop.......sac.Wtps........Phslhh.p.........lYlFNhTNs--hhs..ut+PplpElGPYsY+.EhtpKhslpassss...Tloa..ppp+sahFpP-...hSsG.....stsDhlsssNlshlussthhpp..........hs.hhp...............................................hhlshhlpt.....stphF.hspolt-hLa..........GacDsl..lshhpp.........h...............spFGhhhs..cNso...sshaslhTGtc.shpphGh..........lppasGpsph..sh...............Wps.........C.s.....plpGo.-GohFsP..h.lpp.pcslhh..Fts-l.CRslp...ltappsss.hpGIpsa+atss.spshsssptpspstCa................C.tstt...........................Ch.sGlhslosCh....G..uP....lhhShPHFa..tAD.phhpslp.Glp.Pst-cHp.halslcPhoGhPlp.sptRlQlNlhlppsps..h.shhps.hs.shlhPlhWhcpss.tlscphhshl.ptlhhh.plhthhthshlslGllhlhhhlhhhht	.................................................................................................................................................h...............................h.p.th.lt...ss.............hp..W..p.............sh.hhh..p..............hahashpNspchht....s..tp..lpphGPYsap....chh.+.sl.p......t..tp...s......plsa.....p.h.F..p..........hS.s.......p-.lhh.Nh...hhsh..h..htp.......................hhp..................................................................................................................................................................................hhhs.h.hp..........ttt.h..hp.....hss...t-hha..............Gaps..h......hphh........................................................th.u.hh.......hNso.......ss.hphhsGhp..sh....t.ph..s...........................................l..pa.p.s.p..ph......sh..............................ats................C.s................l.pG.o..suph.a.P........h...hp.....pp...l.h..a...........-h..C.....R...th......h.atpp........hp.G.l.s...h+ahhs..p.hs.s.s..t............st.sa................................................................C.......................................C...tGhhsls.C...........s......tP..................lhhShPHFh....us..........h..........h..p..t.l..p......G..........h....p....P.s.................cpHp...hhh.lpP...............h.....sGhshp.sth+hQhNhhlp..tt....................h....h.t....p.....h............t................hh...hPhhah.p...................th....h.s.tthhp.h.......h..h.......h......h.h...h...hh.h....hh.uhhhhhh...h....h........................................................................................................................	0	248	319	521
+1497	PF04549	CD47		CD47 transmembrane region	Mifsud W, Bateman A	anon	Pfam-B_2739 (release 7.5)	Family	This family represents the transmembrane region of CD47 leukocyte antigen [1-2].	25.00	25.00	26.70	27.80	21.20	23.00	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.25	0.71	-4.22	13	120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	61	0	25	104	0	151.00	44	53.06	CHANGED	hlIllhhhlhllLhWupls..hlohKh..sphc+hIhlhhssulllTlIslVGtalh.lssthshhphpGlsLI.lshhh.IhLphhla.htltho.phhIsllllQlluYlLollslsLslhsC.pslaG.LLI.sLhlIslhELhuLlhhhh...hsssp+shh	............hLlhIFshlsllLhWhphu..hhol+h.Ssshspph.hhLhVhGhllolIhlsGAhLF.hP.u.aol+phhGLhhhslsohhLIllphhsFhh..hhtho.shlhhIlhhQllGYILsVlGLuLslptC...VcGsLLlSGLuhIsluELhuLlahhh...hsSsQ+sh.............	0	1	1	4
+1498	PF03234	CDC37_N	Cdc37;CDC37; 	Cdc37 N terminal kinase binding	Bateman A, Wood V, Mistry J	anon	Pfam-B_3345 (release 6.5)	Domain	Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domain corresponds to the N terminal domain which binds predominantly to protein kinases [2] and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain Pfam:PF08565.  Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability.  This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function [2].	26.10	26.10	26.60	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.52	0.71	-3.95	21	361	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	238	0	221	333	1	125.20	28	34.41	CHANGED	slDYSKWD+IElSDDSDlEVHPNlDppSFIRW+QpsIHE+RppR+p-hcsLchphphsscLhpRlc+hLspLppp.t..s...........l.....t................................p........ppMh.sLh..l.....p.t.t..........sshhpplppHppKlcshpc-hppKLcELpKccpppIsS-Dl..HsGFspS	..............lDYSKWDtlElSDDpD.-sHPN...lDptShhRh+ppthhcchtp..hppchcplchpht...pthhtchpph.lpphp.p....t..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	68	108	175
+1499	PF02724	CDC45		CDC45-like protein	Mian N, Bateman A	anon	Pfam-B_1919 (release 5.5)	Family	CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae (Swiss:Q08032), forming a complex with MCM5/CDC46. Homologues of CDC45 have been identified in  human [1], mouse and smut fungus (Swiss:Q99107) among others. 	34.00	34.00	36.20	34.90	33.60	31.70	hmmbuild  -o /dev/null HMM SEED	622	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-12.88	0.70	-6.49	33	405	2009-09-10 22:41:12	2003-04-07 12:59:11	9	4	282	0	267	409	17	488.50	28	92.86	CHANGED	.VlllVuh.-lDALCAs+ILssLhKpDhl.apllPVtGYs-L.............cpthpch..spshpp...........llhlsCGuslDLtshLphs............................tshplaVhDuHRPasLsNlau....................................ssplhlhsDssh--phpt....cc...hapth........................cs-s-s-..s-s-s-sssp......pc.........t.ts.ppttcpc.hphcRp.p...................................................++pp++.hccpcphlpthYppushaupSsuhhlYsLA.plu+s..st.-hLWhAIlGlosh.l...................tthstppYsph.hthLpcEVpRLssps.....................tssspos............................sshpIsh.p.-h+LhLhRHWSLY-ShhaSsYluu.+LcLW.o-pGcK+L+cLLA.+MGlsLsps+QsataMDhplK+pLtphlc+.uspaGLpclsht...............uFs+saGa+.splSAuDsVhulsALL........Ess........................................................................................t.....tt.tppcpcphhssFapAhDALs................ppsh-lLppGlphAptLppAIhpsssoll.-p.c.lpshpsF+hsllp-.u...PDlclFspPhsLscLupaLlcuhspp...pcppttt..............hPLVlAu.LcpspsshlVl.Gl..........................................................................s.tpptp...................tNpFuhAFppsuppo.sA+lphDsF-sulIEl+p-DLssFL-sLohtss	............................................lhlh.ss..-sDulCAs+lL.p.tLhpp-.l...aplhPltuht-l.............pp.hh.ph...........p.hp..............hlhlssGu.lDl...p...h...L.t..t...................................tth.halhDs+RP.h.slsNlas......................................pttlhlh.c.tp.c.p.......cp...ha.t......................................................ttpptpp..pptt..t..t.tt...................t..............................................t.pc..................................................................................................................................................................................................ppp....hp.hpt...ct.l...Yp.hp.aups.u.hh..........ap.L..u..hs+p.......p..-...h...LWhullGlos..l............................thh.t.th.t...h..lppcVp...phs..p.....................................tp.hs.............................pp.p.lth..p.-..................phhL.hpHWoLa-Shh.osahss.phphW..s........p.................G...........tc+Lpphl....A.cMG.lsLtp..spQpat......Mshpl+cplhphh.c..h..ash..pphh.................sF.hpaGap.tph.AtDhshshhulh........Es...................................................................................................................ttttthhtpFhtAhDuLs.......................s.p.L.tul..hAp...pul..ppstshl..pp.p...lhp.t.....ahhs.l.....-..u............s-.ht.hFsp.P.hsL.hLu.alhcshh.p........tttt..................................hPllhus..h.......s..p.pshhhll.Gh..............................................................................................t........................hN.Fu.AFppsstps.ss...p.hhhs.F-.shlplptp-hs.FhptL.....h...................................................................................................................................................................................................................................................................................................................................	0	106	156	224
+1500	PF02933	CDC48_2	cdc48_2; 	Cell division protein 48 (CDC48), domain 2	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_799 (release 5.2)	Domain	This domain has a double psi-beta barrel fold and includes VCP-like  ATPase and N-ethylmaleimide sensitive fusion protein N-terminal  domains.  Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate  185-residue recognition domain [1].	22.40	22.40	22.40	22.60	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.88	0.72	-4.33	103	1049	2012-10-01 20:15:13	2003-04-07 12:59:11	12	16	512	49	687	1072	104	68.70	25	9.07	CHANGED	thsss.ht.hltpphts..pslstGphl..............hh...sh......h..................sptlphtVhsspPss.............sl.hlscsTplpl.t......pcssph	..............................................hsss.hshhlp..h.Fhp...+PlppG-hh..............................hl....ph.t...........................hpsl.pFp.....VspscPss..................hs.hls..sT.lphp.....tcs...t......................................	0	197	383	563
+1501	PF02359	CDC48_N	VAT-Nn; cdc48_N; 	Cell division protein 48 (CDC48), N-terminal domain	Bashton M, Bateman A, Griffiths-Jones SR	anon	Pfam-B_799 (release 5.2)	Domain	This domain has a double psi-beta barrel fold and includes VCP-like  ATPase and N-ethylmaleimide sensitive fusion protein N-terminal  domains.  Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate  185-residue recognition domain [1].	25.10	25.10	25.10	25.10	24.90	25.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.64	0.72	-4.04	120	1252	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	680	48	754	1224	114	82.90	27	11.30	CHANGED	pLpVscAh.pp....csspulsplsspshppLslptGDhlplpG.c+p.Ts.shVhsstsp....sp....tshIRhsshhRpNsslulGDpVpVcpsp.s	................LhVscs....p.......spul..ltlsssshppL.....t.l........h...pGD.s....l.hlpG..c+.......p..Ts.shVhsscsp.........st.....uplphst.....s.hRp.NhtV.p.lG..DhVsVp.ss..h...............	0	221	435	635
+1502	PF03381	CDC50	DUF284; 	LEM3 (ligand-effect modulator 3) family / CDC50 family	Mifsud W, Kerrison ND	anon	Pfam-B_2846 (release 6.6)	Family	Members of this family have been predicted to contain transmembrane helices. The family member LEM3 (Swiss:P42838) is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells [1]. The products of genes YNR048w (Swiss:P53740), YNL323w (Swiss:P42838) and YCR094w (Swiss:P25656) (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39 [2]. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure [4]. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway [3]. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants [2] may be due to inactivation of CDC39.  The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.	26.70	26.70	30.50	28.00	18.90	26.60	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.00	0.70	-5.23	76	747	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	312	0	511	720	9	276.90	32	77.38	CHANGED	l.....hhsupplp-lpl.cYsssstsss..................................................................sCplsFsls....pphcu.PlahYYpLsNFYQNHRRYVpShsppQLpGct.hs.sp.......tCcPhph........................pssc.hh...hPCGLIAsShFNDTash.....................sss..sssh....................shs.....ccG..IuWpoD..+pp+a+p..sph.p.t...........s.P.sW.t................................shp.ss.hPssp........pE-FhVWMRoAALPsFpKLat+h.......sssL.sGp.YplpIp.NY.....PVppFs.Gp..KpllloTsShhGG+N.FLGlsYlllGulshllulhh.llhahh.ps+.....phu-ts	...........................................................................h.hhsuppl.El.h.cYspsp..ss..........................p..............................................hCplpapl.s....p.ph.p....s.slahYYpLsN..FYQNHRR.Y..VpS.hs.spQLpGps..hshps..............psCpPhphs..................................................tssc...slhPCGhIAsShFN..D..Tash..................sssspth............................................shs.......ppG.IuW.o.D.+.t+Fpp.....sth.t.t...................................ths..Ps..sW..p.......................................................................................shp..ss..P.s.p............sE-ahVWMR...TAALPsF+KLYt+lt...................pssL.sGp.Ypls.I.p....s.a.............sVtpFs.Gp..KpllloTt.o.hh.GG..+N..FL...GluYlllGulshlhulhh.hlhhhh.h.p......p...............................................	0	183	288	415
+1503	PF02611	CDH		CDP-diacylglycerol pyrophosphatase	Bashton M, Bateman A	anon	COG2134	Family	This is a family of CDP-diacylglycerol pyrophosphatases, EC:3.6.1.26.  This enzyme catalyses the reaction CDP-diacylglycerol + H2O <=> CMP + phosphatidate.	25.00	25.00	26.70	26.60	24.00	23.90	hmmbuild  --amino -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.54	0.70	-5.10	24	718	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	658	2	75	359	4	208.40	62	86.80	CHANGED	ssDALW+IVpppClst.ppssssuPCspV..c.....ptGhVlhKDtsGshQYLLhPTt+loGlEuPtLhpsssPNaahtAWpARsahupchGpslP-ssluLAINSphGRoQsQLHIHIuClpPslpptLspts....sshsspWp.LPh.L.....pGHpYhA+pVsss-hspt..sPFphLsccl..tupscMuchululsshssss....FlLLsophchhshs.uSAEElQDHsC.plhc	..............................................................................sDsLRKIVhEpCLPs.Qpps.QNPuPCAEV.....KP....sAGYVVhK...D.hpG.P.LQYLLMPThRIsGhESPLLh-PuTPNFFaLAWQARsaMScKYG..pP......lPDpAVSLAINSRp..GRTQNHhHIHISCIRPDVRcQLDssL.....ssIoo..RWhPLPGGL...........tG..H-YL..ARRVTESELsQR..SPFhMLAEEVP.-AR-+MGpYGLAhVRQSDsS.....FVLLATpRNLL.T..LN........RASAEEIQDHpC.pIL.p....................	0	9	33	55
+1504	PF03598	CdhC		CO dehydrogenase/acetyl-CoA synthase complex beta subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.60	20.60	20.60	22.80	18.10	16.30	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.37	0.70	-6.01	22	260	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	146	27	85	256	20	281.80	45	67.47	CHANGED	tl-IPVshuPsaEGERIR+sDMaVEhGGs+.o...uhELVpshph-E.lEDGKlpVlGPDIc-h-.EGs.phPluIll-luG+chpcDaEsVLERRlHcahNYspGlMHlsQRDhsWlRlSK-AhsKGhp.LcHlGclLhshh+pEF.sll-+lpVTlhTDtpcV......pchh.ppA+thYcpRDcRh+sLoDEsVDsFYuCsLCQSFAPoHVCllTP-RsuLCGAlsWhDu+AuhclsPsGPp.PItKGcslDsptGpapuVN-hltcpSpGsl-+lsLYSlhppPhTSCGCFEsIshhlPEssGlhlVsR-asGhTPsGhsFSTLAG.sGGGtQsPGFhGluhpYhpSpKFlpADGGhpRlVWMPKpLK-plp-pls.........c-hhDKIAsEpsuoo.EElhtFLccpsHPslsh.......-sh.	...........................h.h.hush.tGE.lRt.ph.hEhsG.p.....shEhl.h.....tp....htDtplplhG.-lt..p.h.......u.........s........hu..hhhpl..G.cth.p.D...hEs....lh..ERphH.hhshh...pGhh.+..h..sQ..R.....hhRlsKtshttGht.hpphuphl..hhhtch.shl-phplhhhTp..tth.......p.h...s...at.RDt+htt..h.--ts-.aYsC.hCQsFuPsplChlsP-R.uhCGuhsaLDAKAstclcPsGPsQslsKtpslDEphGtapsVNEhVpchSpGslEcVsLYSlhcpP.TsCGChEslhhh.P..sGhhhspRta..s.sP.Gh.FsthAu.huGG.p..GahGhsh..h.p.+hh.u-.GG..RhlWhst.hKp.l...h............phhthlssEp.s.t.ttl..al...........................................................	0	37	65	75
+1505	PF03599	CdhD		CO dehydrogenase/acetyl-CoA synthase delta subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.24	0.70	-5.97	9	289	2012-10-03 05:58:16	2003-04-07 12:59:11	11	5	140	16	156	518	200	303.70	26	74.61	CHANGED	EVslGs.......pcpsVhlGG-csLaR....a-hsh.N.sslshDV.D.h.st..Ksltcchpclhpp...at+hpVtc.hshDhlsI+thSsDP.......cchscslEcVhpulshPlllsu......DP-VLctAhEVscsc+sLLhuAsh-.sacchschAhcYspsVls.au.tDlsthKsLs+plhp.sGl..ccIVhDPsT.ts.G.GlchohsshhpIRhsAlcG.Dc-lsaPI.uhsssAahsc............u.hVs.............................................pP.ts-ssh...Gss-.cuPla.hTs.............................GlshulAGspl.......................hhhl.PshsAsL+thhEshTGhpshVGstDsutlhshl	......................................................ltlGs.......tppshplGG-s..s..L..ap...a..-tph....s.shluhcl.Dh.hs.p...t......pshhpth...pc....l..p..........plt..p..hts..-hl.sl.+..h.....h...u..s..c.s....................cchspslc.p.V.h.p.s.s.c..hPlllhus.....Dsplhctsh....csst...sc..p..sLl..h..u....Astp.....N....a..ct..hst.h.A.ht.as...t..s.....lhs.............u.................h......-..........l.......s....h..........h....c..........p..........L..........s..h..........h...........l...........t......p....hGl.............cclVhDs...ss.ts.......u......s....l..c.sh....s.sh..p.lRhu.A.lpt.Dc.lshP.h.h.s.h.s.h.p.sh....s.p..................................................................................................................................................................................................................................h...................................................................................................	0	73	128	142
+1506	PF02234	CDI		Cyclin-dependent kinase inhibitor	Bateman A, Mian N	anon	Pfam-B_1698 (release 5.2) & Pfam-B_5787 (Release 8.0)	Family	Cell cycle progression is negatively controlled by cyclin-dependent  kinases inhibitors (CDIs). CDIs are involved in cell cycle arrest at the G1 phase.	20.70	20.70	21.20	22.00	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.62	0.72	-4.17	43	388	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	133	2	195	364	1	50.30	34	25.13	CHANGED	Rshhh..Ps.cpElcc.aptt.cc.pcchpc...KaNFDFhs-pP.L..s..GR...Y-W.c..ls	......................thFs...Ps.p..pElp.c.hptthp..p....h..pcptpc...KWNFDFhs-pP.L....p..G..+....acWpcl..............	0	39	84	138
+1507	PF03261	CDK5_activator		Cyclin-dependent kinase 5 activator protein	Mifsud W	anon	Pfam-B_4160 (release 6.5)	Family	\N	25.00	25.00	42.40	27.30	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.29	0.70	-5.11	5	198	2012-10-03 00:42:12	2003-04-07 12:59:11	10	3	77	10	122	170	0	210.00	37	88.33	CHANGED	MGTVLS........LSPuS.....RpusLa--.tcs...GussLusYTusssuKuuKu..EKsL.......KRHShlIsALoWKRLVAutSsKKKsSKKuosN...............sSSuYpspltpLN+ENlcKS...........hPhs..h.LsssNhuoacp............................sPupssAPs....supLuuKss.s...............lus.csAPs.t.susGtoP+RVIVQASTSELLRCLG-FLCRRCYRLKcLSPuDsVhWLRSVDRSLLLQGWQDQAFITPANVVFVYLLCRDVlsG.E...luo-cELQAslLTCLYLSYSYMGNEISYPLKPFLVEssKEsFWDRCLslIsphSsKML+INADPHFFTQVFoDLKNEGsp-	....................................................................................................................................................................................................................................................................................................h.......K+.....h.s.hsh+.hs.....tt...t..t............................................................................................................................................................................................................................................................t+hll.QASTsELL+sLG.Flpp..............+C.........tl.pp.....hpssc.lhWhRsVDRuLLLQGWQD.uFls....PANlVFlYhLsR-.ltt.p....................tp.t-Lpu.hLTCLYluYSYMGNEISYPLKPFLl..-ss+-tFWpRCl.llp.hSspMLplNspstaFTplFt-LKt.....t....................................	0	27	46	88
+1508	PF05174	CDRN		Cysteine-rich D. radiodurans N terminus	Yeats C	anon	Yeats C	Domain	This domain is found individually and at the N terminus of a few multi-domain proteins. 	25.00	25.00	102.00	101.10	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.58	0.72	-4.50	5	6	2009-09-10 20:04:58	2003-04-07 12:59:11	7	5	1	0	6	7	0	55.30	73	18.45	CHANGED	phastsLEQFSELRVRRNSTATRSIL.......RPAhCFALAPLA......KKLCHLFVKCSRLs	....astsLEQFSELRVRRNSTATRSIL.......RPAhCFsLAPLA......KKLCHLFVKCS+Ls.	0	6	6	6
+1509	PF03498	CDtoxinA		Cytolethal distending toxin A/C family	Griffiths-Jones SR, Bateman A	anon	PRINTS	Family	\N	21.60	21.60	21.70	21.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.12	0.71	-4.83	10	430	2012-10-02 19:42:32	2003-04-07 12:59:11	9	1	170	6	23	258	3	145.30	32	69.60	CHANGED	hlSlhu.toGulLosathss+sal...Wshs.lcos-auch+s.phhsh.shGhlpF+Nsssus.Clss...htsGhhtst..Csss....shpplFsLlPosoGAVQIKS..lusGpClpsshssph....hhhslplscC..shup...psshsphWhIsPP...spsspP	.........................................loIhu..oGhsLosathsstshl...Wshp.lsup.shtc.tRs.plh....s.saVphpNs.+sss.CLss......hts.Gh....hth...........Cpps......shtphF.....plhP.h.os..GAl....QI+s.....lsss..pClps...hsssh.....h.hpht.lscC.....s.th...ptshsp.ahlosP....htA.....................	1	3	15	19
+1511	PF00272	Cecropin	cecropin; 	Cecropin family	Finn RD, Bateman A	anon	Prosite	Family	\N	29.40	29.40	30.00	29.70	28.90	29.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-7.00	0.72	-4.39	28	182	2009-09-11 13:43:56	2003-04-07 12:59:11	14	1	57	10	56	210	0	30.50	49	49.92	CHANGED	chhKKlE+sGpplRDAlIp....AuPAlsVlupA	.KlhKKIE+lGp+lRDAhIp....Ap.AlsVlusA...	0	15	26	47
+1512	PF02927	CelD_N	celD_N; 	N-terminal ig-like domain of cellulase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.04	0.72	-3.73	42	561	2009-01-15 18:05:59	2003-04-07 12:59:11	9	36	362	16	169	519	19	88.60	25	12.13	CHANGED	sstsstsss...tl+VNQlGYhPsusKhAslsssuss.....s.taplhsusGss.VhsGpspst.uspss.....................SGppV+hlDFSshp.ssGs.YpLpl..sGt..pSt	.................hs...........lhlNQlGYhspu.s.KhAslhss.psp......................s.pap..l......h...s...s.sspp...Vh.p.Gphp.t...ss.st............................st.pp..ht.h.lDFSshp.ssGp.Yhlph..ssh.....p.....................	0	100	148	161
+1513	PF03500	Cellsynth_D		Cellulose synthase subunit D	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.30	21.30	21.70	21.80	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.94	0.71	-4.51	2	86	2009-09-10 23:58:10	2003-04-07 12:59:11	8	1	83	16	36	84	2	124.90	30	81.81	CHANGED	FoLFLQsLSWEIDDQsGIEVRN-LLREVGRGMusRl.PP.CpTlcpLQIELNALLuhIsWGhVpLELLuE-QuhRIVHEsLPQVGSAGEPSGTWLAPVLEGLYGRWlTSQsGAFGDYVVTRDVDAEDLNuVPpQTIIhYMRsRS	..................hth.....................pshL+phGpplAppaPLPsucTlu-LEpslNtlLschsWGaVplc..sp-suLpltHpAhPh...s..stucst.t..pW...h...s...A.lLEGlYupWLpuQuG.u...............................thsh.t.t................	1	1	9	23
+1514	PF03552	Cellulose_synt		Cellulose synthase	Bateman A	anon	Pfam-B_1346 (release 7.0)	Family	Cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues, is the major component of wood and thus paper, and is synthesised by plants, most algae, some bacteria and fungi, and even some animals. The genes that synthesise cellulose in higher plants differ greatly from the well-characterised genes found in Acetobacter and Agrobacterium sp. More correctly designated as 'cellulose synthase catalytic subunits', plant cellulose synthase (CesA) proteins are integral membrane proteins, approximately 1,000 amino acids in length.  There are a number of highly conserved residues, including several motifs shown to be necessary for processive glycosyltransferase activity [1].	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	722	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.18	0.70	-6.24	15	1407	2012-10-03 05:28:31	2003-04-07 12:59:11	9	33	149	0	613	2401	43	403.60	33	73.03	CHANGED	VDlFVSTVDPLKEPPLVTANTVLSILAVDYPV-KVSCYVSDDGuAMLTFEuLuETA-FA++WVPFCKKasIEPRAPEaYFutKIDYLKDKVpssFVKERRAMKREYEEFKVRINALVAKApK.....................................lP-EGWsMQDGTsWPG........NNsRDHPGMIQVaLG.sGucDl-GNE...............LPRLVYVSREKRPGYsHHKKAGAMNALVRVSAVLTNuPFILNLDCDHYlNNSKAlREuMCFMMDPslG++lCYVQFPQRFDGIDhsDRYANRNTVFFDINM+GLDGIQGPVYVGTGClF+RpALYGY-PPpspch.c.s.........ssCChGp+Kpspstppsp........................................p..pcp-pptshashp-l--s....h..s-.E+t.lhoQpslEK+FGpSslFlsSThhpp.....................GGlPc..sssPAsLlKEAIHVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHsRGWRSlYChPKRsAFKGSAPINLSDRLHQVLRWALGSVEIFFSRHCPlWYGat.tRLKaLpRlAYlNohlYPFTSIPLlsYChLPAlCLlTGKFIlPoLoNhAulaFLsLFlSIhsTulLElRWSGVoIE-WWRNEQFWVIGGsSAHLFAVFQGLLKVLAGlDTNFTVTSKuu.s...tD--FuELYlFKWTTLLIPPTTllIlNlVGlVAGlScAINsGYtuWGPLFGKlFFuFWVIlHLYPFLKGLMGRQNRTPTIVlVWSlLLASIFSLLWVRIsPFlscssusshp.p	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hp.......t.......t.......G.......W.Shhh...........................................h....G.s.s.sh.t.....h.Q.hRW..G.h...............ph.hh.s.p.........s.....sh.....hh............s.......................t.h................th...a.......................s..h.........hhY.h.h.s......h...h........h.......t...........h................................................................................................................................................................................h....h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	59	399	517
+1515	PF03040	CemA		CemA family	Bateman A	anon	Pfam-B_1775 (release 6.4)	Family	Members of this family are probable integral membrane proteins.  Their molecular function is unknown. CemA proteins are found in the inner envelope membrane of chloroplasts but not in the thylakoid membrane [1]. A cyanobacterial member of this family has been implicated in CO2 transport, but is probably not a CO2 transporter itself [1]. They are predicted to be haem-binding however this has not been proven experimentally [2].	20.80	20.80	21.00	21.00	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-4.75	53	734	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	614	0	83	652	29	213.40	50	80.88	CHANGED	hu+h.pshsSlpYLhhL...lhlPhhlshhh+phhlpPhlspaW..NspQsplFLNs.QEcpALc+hpchEEhlhhDphl.p.....tsphp.pclphpI+ccslpLschasp-ulpsIhplhoslluhshhsshhlhG+cc.LtlLpSalpEhlYuLSDThKAFhIlLhTDlhlGFHSPHGWEllIsulhcHaGhscNcp..hIshFVuTFPVILDTlFKYWIFRYLNRlSPShVsoYHsMNE	..................................................t+hKshsslhYLss..l...VhLPWhlshs..hpKs.LEsWl.s.N...WW.....NTtp...Sc...hh...lstlQEc...s...hLc+F.hcl..EELhlL-cMl.c................-....h.s..pTH...........Q...c..l..c..ItI..HKETIQLlchaNE-p.lchIhHh.TNlIsFshlSuah..............IL...Gpcc.LsILNSWlQEFhYsLSDThKAF.ILLlTDLhIGFHSsHGWELhIsulhcc.aG..hs..cN-p..IISsLVSTFPVILDTIhKYWIFRaLNRlSPSLVVIYHSMN-.....................................................................	0	16	53	72
+1516	PF03879	Cgr1		Cgr1 family	Wood V, Bateman A	anon	Wood V	Family	Members of this family are coiled-coil proteins that are involved in pre-rRNA processing [1].	22.50	22.50	22.60	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.22	0.72	-10.74	0.72	-3.88	18	165	2009-09-10 18:08:07	2003-04-07 12:59:11	9	5	161	0	121	151	0	105.60	41	66.03	CHANGED	pst..scGhRlNGKsW+spKcsFRssu.......phTSaEpRtpcRhpppthKt+EKELK-EKEspRp....p+IptlK-RRttKEEKERYE+MAtKMHtK+VERh+RREKRNKhL+p	...................s..scGhphsGKsW+s.s.Kp..s.FRsps.....................t.hTSaccRhpcRtptpthKp+pKElK-EKEs-R.p.....p+Ipt.l+-RRttK.EE.+....E.R.Y.E+hAt.K......M.H.t.K+...VERhKR+EKRNKhLpp..........................	0	35	66	103
+1517	PF04752	ChaC		ChaC-like protein	Mifsud W	anon	Pfam-B_3722 (release 7.5)	Family	The ChaC protein is thought to be associated with the putative ChaA Ca2+/H+ cation transport protein in Escherichia coli. Its function is not known. This family also includes homologues regions from several other bacterial and eukaryotic proteins.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.26	0.71	-4.32	15	1371	2012-10-02 16:39:48	2003-04-07 12:59:11	7	12	1051	0	511	1064	243	169.70	37	77.62	CHANGED	lWVFGYGSLlW+PuFsas-phhual+Ga+RpFh.ssscHRGTscpPGRVsTLhcs.t.........................utshGsAY+lsutph.ttslpaLp.REh..sG.ptppl.hh...................psssspssh.psllaluos...pNptYhGss.sl-chAp..............pIssAsGsSGsNt-YLFpLtctLcpls............................hcDcaLhcLtptVcct	.................................................lWlFGYGSLh........W...p.....Psh.....t.......as..E......ph........s.up.ltGa+RsFh.h.............t....sp....s.tRG..Ts..cpP..GRsluLcc..u...............................................................GpshGl..AYRlst..p..p.h..cp..t.lphLhcREh...hs.....t.phlshah.............................................................p..ss.st..h......pA......lsalhs................cpspYt...ust...sh...pslAt..............hIusAsGs.GsNt-YLhpLtptLpphG..............................hpDctLppLhttVt..h..................................................................................................................................................	0	128	251	387
+1518	PF00195	Chal_sti_synt_N	Chal_stil_synt; 	Chalcone and stilbene synthases, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase.\	  The differences in activity are accounted for by differences in this N-terminal domain.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.48	0.70	-5.11	21	3069	2012-10-02 12:25:54	2003-04-07 12:59:11	14	18	1289	101	485	4736	327	174.40	49	54.42	CHANGED	sslEph++AQRA-GsATlLAIGTAsPsNsVsQusYPDYYFRlTpSEHhs-LK-KFcRhC-+StIKKRYhaLTEElL+cNPslCsahuP.SLcsRQ-IslsEVP+LGKEAAtKAIKEWGQPKS+ITHLVFCTTSGVDMPGADYQLo+LLGLpPSVKRlMhYQQGCaAGGTsLRLAKDLAENN+GARVLVVCSEhTslsFRGPS-s+...hDsLVGQALFGDGAAAlIlGoDP	................................................................................................................................................................................................................t.....h....h..........p........h.h...t..t..............s...lppRh..hh.....h..................................................t.......................h...............................................s...s....h.....p.Rp.c...h...h..h.....c...s..s..c.L.up.-.AAhc.Al...c.....E.....W......G.....t.....s..t.....o....cI.TH.l.l.h......s.T..o..o..G...l.s.......h....P..G..s..D.h..p.Ls.p.hLG..L.+..s.oVc..Rlhh..a..p....G..CaAG.us..........s..L.R.h.A.K.D...L....A....E....N....N....t....G....A..R.V.LV..VC...SE....l.T....u..l..o.....F...R......u.........P....s...-...s...+..................L.-u.L....V.......G..pA.....L...FGDG.A.A.A.l.I.V.GuDP.............................................................	0	109	314	416
+1519	PF02797	Chal_sti_synt_C	Chal_stil_syntC; 	Chalcone and stilbene synthases, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain of chalcone synthase is reported to be structurally  similar to domains in thiolase and beta-ketoacyl synthase.   The differences in activity are accounted for by differences  in the N-terminal domain.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.90	0.71	-4.29	21	3003	2012-10-02 12:25:54	2003-04-07 12:59:11	10	16	1211	100	498	3983	257	132.70	50	39.80	CHANGED	ELVSAuQTlLP-ScGuIsG+LpEhGLTFHLh+DVPtlIScNIEcsLhcAFsPlGIs......DWNSlFWlsHPGGPAILDQVEtKLsLcPEKLcAoR+VLSEYGNMSSACVlFlLDEMRKpShccGtsTTGEGL-WGVLFGFGPGLTlETlVL+SVs	.........................................................................phhtuuQTllPDS-...uA.IsG+.L.R..E.s..G.....L..T.F.H.L..h.+.-.VPsLISc...NI.c...c..s..L.......sc.A..F....p......s...l......G..I.o.................D....W...N...s..l....F..W..I.u.HPGGPAILD...pV..Et+L.......sL..c..c.....K.lcuoRcV...L.uEYGNMS.....SAs..V.LF.l.L.D.-.h..R.c.p..........s..........h.....p....p.......t.....................t.......p..........................h.....c....hG............l...hhu.aGPGhshEhh......................................	0	132	331	436
+1520	PF02431	Chalcone		Chalcone-flavanone isomerase	Mian N, Bateman A	anon	Pfam-B_2073 (release 5.4)	Domain	Chalcone-flavanone isomerase is a plant enzyme responsible for the isomerisation of chalcone to naringenin, a key step in the biosynthesis of flavonoids.	23.00	23.00	23.10	23.10	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.18	0.71	-4.92	60	585	2009-09-11 05:35:35	2003-04-07 12:59:11	10	8	320	25	257	589	20	182.60	24	69.08	CHANGED	FPss.l.p.ssss.........................pshhLlGt...................GlRslshh...tlKhhulGlYlpss.........slspltsphpucssp....................................-hpcu.phacsllsu.sh..cphhRlshl+s.lshpphp-tlscslhuphpths....................hs......-ppspAlccFpph...F..psc.shPtGsslhhph..sssG.s......Ls.luasppsp...............tpthuslcsch........lucslhppYl.GcpslSPss+cSluppls.sl	............................................................................................pth.LhGh........................................G..hRshph.....lphhulG.............lYlptp...............sl.t..h..tt..hhtp.st....................................-.tps.thapslls....s....s...h...cphh+lshl.hs.lshpphp-thtcshhsphpphsh............................p...-sttpul...cc..Ft.ph.....F....psc.shs.Gsslhhph.sssG..s..............Lp..lshs.t..................tp.thuslpsph...........lscslhp.al.Gcp.ssS.ts+pslspth.t.........................................................................................................................	0	78	167	221
+1521	PF03502	Channel_Tsx		Nucleoside-specific channel-forming protein, Tsx	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.50	20.50	21.40	20.80	20.10	19.30	hmmbuild  --amino -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.70	0.70	-4.57	44	1502	2012-10-03 17:14:36	2003-04-07 12:59:11	8	2	831	6	162	633	25	237.30	33	88.51	CHANGED	tsshpWhphshhhu.t.phs.....pps-....csYLEhEaGG+suhhDLYGYlDl.slt..sspsscp...ttt.sphFhchtPRhSlDthoGcsLuaGPhpElYh.......us.hsast.............................s.ss....hhhGlGsDl.sshhsphshNlaupYshpsh..............pasGaphp.ssWhtPahhhtssshloapuah-apFutcpthts.........psssGhshhhulaW+.o-ca.......ssGhsh+hacshh.htst...............huhcooGhuaYhslsYcF	..........................................................................................................................h.p.h.apShslhss.p.chu.......phss......psY.LEhEsuuphsWh-hYGahDh.shhs...tpspst..........s.oshahchcPRhSIctlsssp.hsFGPap-hYh.......As.s...h.as..............................cpss....ahhGlGhDl.oGhshhhphNlYt+Yp.psY...............pasG...aphp..ltahsshs.hhhsupphohpuas-a-asp...Dtu.sssp...........tspsul.s.uuhh..Lths..hs+a.......phulshRYacsththt..s.............hsh.cs.hG.uhhhslsYpF..............................	1	24	50	109
+1522	PF03924	CHASE		CHASE domain	Yeats C	anon	[1]	Domain	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases [1,2].  Predicted to be a ligand binding domain [1].	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.08	0.71	-5.08	191	1214	2009-01-15 18:05:59	2003-04-07 12:59:11	8	223	668	14	443	1200	120	181.20	18	21.82	CHANGED	sstsl.spscacsasps...lhpphsuhpuhs..at.plstpc..h..statpphppp......thst..apl...........t..................sps.hhslhalpPhs.tNppAlGhDhtopst++tAhpc....Atpoups..slouslp..LlQss......ptGhl....lhhPVa.tt.........................t.....pphhGhlhushchsslhpshhtpp.........tplslplhD.................spssssplh.ass	........................................................................................tphtth...htt...h.tt...hssh..u.ht....h......p..lt...tp....h..tthtt...phttp...........h.......hpl........................................tts.hhslta..l...........Phs....tNppsl..GhDh..ts......p..sp..p..p..ps.ltc....Atpssps..slouP.......lp...L......lQss............t.G.hl..lhhPVa...p.t.....................................tp.................pphhG..........h.lsushchsslhpshhh.tt............plslplhD..................ts.tt...hh..............................................................................	0	131	283	371
+1523	PF03173	CHB_HEX		Putative carbohydrate binding domain	Bateman A	anon	Pfam-B_8666 (release 6.5)	Domain	This domain represents the N terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure that is similar in structure to the cellulose binding domain of cellulase from Cellulomonas fimi [1].  This suggests that this may be a carbohydrate binding domain.	25.00	25.00	26.20	25.30	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.97	0.71	-4.79	6	353	2012-10-01 21:34:18	2003-04-07 12:59:11	8	7	306	4	75	309	10	155.80	34	18.70	CHANGED	sNLclphpllcshsuppshsCssht......s.huuCh+lphohsspspsscuc.DasIYFpSl+hshps-u-pFtIsHlsGDLHKLpPTstFuGhsuGcohslplsuphWQlhcoDhhPphal...ousstcPcsltsTs.......TE.........-lstFlsshs...ssQhKpTscDpsshtsuss	.........................................................LtlphplhsNpuuptGhsCttht.........A-hAuCsps........phsLs........NpG.pss......uc.DWsIYFp.S.I.Rh.l..........L........p.l.s.s.s.......p..............F...........p.ls+loGDLa+lpPTcpFsGhusG-slplPhluEYWplhpoDhhPphal........sussAcP.clltshs.......T-..........DhstaVpshp.......sp...ph..+R..o.....s...Dps.hhps..t.....................................	0	18	32	55
+1524	PF03174	CHB_HEX_C		Chitobiase/beta-hexosaminidase C-terminal domain	Bateman A	anon	Pfam-B_8666 (release 6.5)	Domain	This short domain represents the C terminal domain in chitobiases and beta-hexosaminidases EC:3.2.1.52. It is composed of a beta sandwich structure [1]. The function of this domain is unknown.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.92	0.72	-4.14	264	1239	2012-10-03 16:25:20	2003-04-07 12:59:11	8	244	639	4	431	1707	370	74.60	23	9.83	CHANGED	ssshhssssG.shts...s.pls.....lss.tpsss.....sIaYThD.GopP........ots..S.phY..................s.s..P.lsl..ss.s...........l+shuh..sss.tpsSpltotp	..............................h....h.s.sG...h.t.....stpls.......l..ss..ttsss......pIhY.Th..D.G.o.p.P..............................s.t........S..th..Y.................................s..s..P..l.slspss.s............................l+shuh.....sss.tp.Sphhp..t...............................................................................................	0	199	339	396
+1525	PF01339	CheB_methylest		CheB methylesterase	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	20.40	20.40	20.60	20.60	19.90	18.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.97	0.71	-4.85	180	3655	2009-01-15 18:05:59	2003-04-07 12:59:11	12	120	1959	4	1223	3093	363	180.30	37	42.15	CHANGED	llsIG.uSsG.GspALppllsp...LPs.shs..h.sllllQHhsss.assthschLsptsslsVpp.Ap-Gp.hl..ps...GplYlAPsst.clt...........l..........p...ssp..........htlpht.....sthstt....+..Pol.DshFpSlApthusps.lullLoGhGsDGupGlttl+ptGGh.sl..uQct.pouhhhGMPcuAlp.sG.ssDtllshpcluptl.hph	..........lluIGuSTG.GspA..LpplLps.LPs..shP....sl.l.l.....s.Q.H.MPss..FT.p..uhA...c+L.s.ph..s.p.l.s.V+E.A.p-.G-..hl...ts...GpsY..lAP.G.sp.Hhtl.........tp....sup...................................lplptt.......ssssta....+..PSVDlLFcSsA.c..t..h.G.p.ps.lGVlLTGMGsDGAtGhhtl+.p.s.G.u.h..s.l..AQ...cE..so..s..l..VaGMP+t.Alp.h..G.ssspllsLsplupplh..h................................................................................	0	399	770	1013
+1526	PF04509	CheC		CheC-like family	Waterfield DI, Finn RD	anon	COG1406	Domain	The restoration of pre-stimulus levels of the chemotactic response regulator, CheY-P, is important for allowing bacteria to respond to new environmental stimuli.  The members of this family, CheC, CheX, CheA and FliY are CheY-P phosphatase [1,2]. CheC appears to be primarily involved in restoring normal CheY-P levels, whereas FliY seems to act on CheY-P constitutively. CheD enhances the activity of CheC 5-fold, which is normally relatively low [1,2].  In some cases, the region represented by this entry is present as multiple copies.	20.20	20.20	20.20	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.22	0.72	-4.22	33	1993	2012-10-01 19:50:22	2003-04-07 12:59:11	7	14	662	13	597	2015	46	37.70	36	24.19	CHANGED	httuAlpEluNIhsGsssouLuphht.tpl-hosPslth	......phsulpEluNIhhGsAuTuLSphls.pplslosPpl..h..............	0	261	447	522
+1527	PF03975	CheD		CheD chemotactic sensory transduction	Bateman A	anon	COG1871	Family	This chemotaxis protein stimulates methylation of MCP proteins [1]. The chemotaxis machinery of Bacillus subtilis is similar to that of the well characterised system of Escherichia coli. However, B. subtilis contains several chemotaxis genes not found in the E. coli genome, such as CheC and CheD, indicating that the B. subtilis chemotactic system is more complex. CheD plays an important role in chemotactic sensory transduction for many organisms. CheD deamidates other B. subtilis chemoreceptors including McpB and McpC. Deamidation by CheD is required for B. subtilis chemoreceptors to effectively transduce signals to the CheA kinase [2]. The structure of a complex between the signal-terminating phosphatase, CheC, and the receptor-modifying deamidase, CheD, reveals how CheC mimics receptor substrates to inhibit CheD and how CheD stimulates CheC phosphatase activity. CheD resembles other cysteine deamidases from bacterial pathogens that inactivate host Rho-GTPases. Phospho-CheY, the intracellular signal and CheC target, stabilises the CheC-CheD complex and reduces availability of CheD [3]. A model is proposed whereby CheC acts as a CheY-P-induced regulator of CheD; CheY-P would cause CheC to sequester CheD from the chemoreceptors, inducing adaptation of the chemotaxis system [4].	25.00	25.00	34.30	27.90	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.33	0.71	-4.31	150	1074	2009-11-17 14:42:28	2003-04-07 12:59:11	8	8	935	2	412	920	66	114.90	30	61.85	CHANGED	MLPsssttptt.........ss.s+YushAh-hLlscll+hG.Ap+ppLpAKlhGGAphhs........shhsIGpRNschs+chLpppsIsllucDlGGstuRplhF.s.poGclhl+pl..........tpt.p.....h	................MLPpsstspst..........sss+YushAhchLlschl.c.h.G..A.p.....+..p..cLpAKlhGGAphhs..................shhslGpRNschscchLpppsIsllAcDlGG.s.tuRplhF.s.poGclhl+pl........t......t...........................	0	151	288	351
+1528	PF01739	CheR		CheR methyltransferase, SAM binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_694 (release 4.2)	Domain	CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase - the C-terminal domain (this one) binds SAM.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.07	0.71	-5.02	22	3912	2012-10-10 17:06:42	2003-04-07 12:59:11	13	179	2109	2	1263	3557	543	191.20	32	48.37	CHANGED	NhTpFFR-stpFchLpppll.s.l.phptt...pp.l+lWSAuCSoGcEPYSlAhsltc...hh.sshs..thpIhATDIshpsLppA+tGhYspptl.psls.thhp+YF.ctsstsap....lpscl+phVpFchhNLhs.....shhsphDlIFCRNVlIYFcppsppcllp+htstLpssGhLhlGpSEsls.thsshFphhpsshthh	.......................................................NhTtFFR-sppFphLpcpll...h..t.ptt..................tp..lRlWSAuCSoGEEPYS.lAhhLt-............hh...p.h....h...s.......phpIhATDIss..ps..L..pc..A..+....pGlY...s.......tpp.......l........c........s......l.s.................p...h........h........p.........+........a...F..........c.......t.....p........s......s...p...ap.................lppp.l.+p..hV..p.F..pphNLlp..............h....s.......h......h....s.........p....a.....D...lI.h.C....R.N.V.h...I..YF.c....p.p...s....p.pc...l.lppFt.t.t.Lp.ss.Gh..La..l...Gp...oEsls...th..sphap.h.......h...................................	0	424	817	1056
+1529	PF03705	CheR_N		CheR methyltransferase, all-alpha domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_694 (release 4.2)	Domain	CheR proteins are part of the chemotaxis signaling mechanism in bacteria. CheR methylates the chemotaxis receptor at specific glutamate residues. CheR is an S-adenosylmethionine- dependent methyltransferase.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.39	0.72	-4.60	77	3379	2009-01-15 18:05:59	2003-04-07 12:59:11	10	136	2012	2	1043	2654	197	56.40	24	14.23	CHANGED	scpchptltphlhppsGlslss.hKpshlppRLt.pRhcthslpshscYhphL...pssppp	..................ptcappltphlhppsGIsLss..tKcshlhpRLs.c+.l..c.t...h..s..l..s..sascYhphL...pps.....................	0	348	678	867
+1530	PF01584	CheW		CheW-like domain	Bateman A	anon	Pfam-B_579 (release 4.1)	Domain	CheW proteins are part of the chemotaxis signaling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and other related proteins that are involved in chemotaxis.  The CheW-like regulatory domain in CheA [1] binds to CheW, suggesting that these domains can interact with each other.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.71	247	10977	2009-01-15 18:05:59	2003-04-07 12:59:11	14	74	2190	12	3275	8780	671	135.50	21	33.57	CHANGED	phlhhpluscp........aulsltpVpEllph..sp.hsplspss.shh.......Gl.lslRG....pllPllcLpphhshsstp................tppshllllc..hs.................sphhGllVDplhshhplshcslpss......hs...thsshlpGsshh.......cu......p...............llhlLDlppllpt.t	............................................hlhhp.lu.scp.........aulslt.pVpE..llph......sp..hs...pls...p...ss...shh..................Gl.l.sl..RG.........pllPll..c.L.p..p.h.h.s...hsssp....................................................tppshll.llp....hs.................pphh.Gll.VD.plhs......h.h.p..l....sh.c.s..lpss.................ht...t..ss.h..ls.Ghshh.............cs.........p.....................lhhllDlppllt...h.............................................................................................	0	1032	2073	2737
+1531	PF01111	CKS		Cyclin-dependent kinase regulatory subunit	Bateman A	anon	Sarah Teichmann	Domain	\N	20.90	20.90	21.90	22.20	18.10	20.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.52	0.72	-4.14	33	488	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	312	20	323	442	1	71.50	58	58.47	CHANGED	pIhYS-KY.DDp.aEYRHVlLPK-lsKhlP+s..........+LhoEsE.WRsLG.......lQQS.GWhHYhlHcPEPHILLFRRPhs	.........................IaYSs.KY.D-p.aEYRH.....VhLPKcl...sKhlPKs.........................+LhoEpE.WR.s.LG.......lQQ........ShGWhHYh.lH..cP.EPHILLFRRPl.............	0	119	178	263
+1532	PF04344	CheZ		Chemotaxis phosphatase, CheZ	Mifsud W	anon	COG3143	Family	This family represents the bacterial chemotaxis phosphatase, CheZ. This protein forms a dimer characterised by a long four-helix bundle, composed of two helices from each monomer. CheZ dephosphorylates CheY in a reaction that is essential to maintain a continuous chemotactic response to environmental changes. It is thought that CheZ's conserved residue Gln 147 orientates a water molecule for nucleophilic attack at the CheY active site.	26.70	26.70	26.90	26.70	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.47	0.70	-4.68	60	1206	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1062	4	279	728	51	184.90	44	83.43	CHANGED	ssplapclGpLTRpLH-uLpshtlDp+l.......ctAsscIPDA+-RLsYVlchTEpAAs+ThsAVEtuhPls-pLpspspplpspWpchhppplphs-....F+pLscchcpaLpp.sppsosplpspLsEIlMAQDFQDLTGQVI+RVlsLVp-lEppLlplLh.hu.scpp.tht......................pGP.lss-p+sDVVsuQD-VDDLLuSLGF	.............................................s..clhtcIGpLTR.L+-SL+-L...u..lDptl.......tpAs-sIPDARDRLtYVlpMTtQAApRsLsuV.......EtupPhp-phcpp...Ap.tLp..tcWsc......hht..s......I...-ls-................h...R...pLspcsc.paLtp.Vstc.ouh...ssupLhEIhM..AQDFQDLTGQVIKRhhcllpElEcpLlhl.....Llpsh...sp...ppt.cstc..ps................................psL.hNG.PQl....s..s.....p..+..s..s....V..V.....u..SQDpVDDLLsSLGF....................................................................................	0	63	151	211
+1533	PF00187	Chitin_bind_1	chitin_binding; 	Chitin recognition protein	Finn RD	anon	Prosite	Domain	\N	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-8.90	0.72	-3.97	18	1066	2010-01-08 13:37:10	2003-04-07 12:59:11	14	39	234	154	390	1128	1	38.80	51	11.02	CHANGED	ApQCGpQuGGthCPssLCCSpaGaCGoTs-YCGs..GCQ.SpC	.................ppCG.........s....s....t....hC....s...s......s......l...CCSpaGaCGoTs-Y..C......Gs...........GCQ.u.C...................	0	83	225	335
+1534	PF01644	Chitin_synth_1	Chitin_synth; 	Chitin synthase	Bashton M, Bateman A	anon	Pfam-B_892 (release 4.1)	Family	This region is found commonly in chitin synthases classes I, II and III. Chitin a linear homopolymer of GlcNAc residues, it is an important component of the cell wall of fungi and is synthesised on the cytoplasmic surface of the cell membrane by membrane bound chitin synthases [2].	25.00	25.00	25.10	29.30	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.82	0.71	-4.46	14	884	2012-10-03 05:28:31	2003-04-07 12:59:11	12	12	402	0	349	874	2	143.70	53	23.85	CHANGED	MYNED-lLFsRThHGVMKNIuHLCoRp+SpsW..GtDuWKKVVVCIVSDGRsKlp.RsLshLAulGVYQ-GlAKs.VssK.VpAHlYEYTTQlSIDsshpacGsc....+GlsPVQllFCLKEcNpKKINSHRWFFpAFu.lLpPNlslLLDVGT+PuspSIYpLWKuF	................................................hYNEsch..hhsRThtulhpNIt.hsp.....h....p......p......SphW...........G...t......s..uWpKIVVClVuDGR..sKls.RThslLAuh..GVYQ.-.........G.lA..Kp.......p.VN..GK.-V.sA.HIY..E..............YTTQ..lu..l.s.....p.tp..h....h.t.hp.............pshsPVQhlFCL.KEKNpKK.INSHRWhFpAFuphL.......pPp.........lClL...............lDsGT+Pu.polYpLWcuF.................................	0	111	202	304
+1535	PF03142	Chitin_synth_2		Chitin synthase	Mifsud W	anon	Pfam-B_1787 (release 6.5)	Family	Members of this family are fungal chitin synthase EC:2.4.1.16 enzymes. They catalyse chitin synthesis as follows:  UDP-N-acetyl-D-glucosamine + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N) <=> UDP + {(1,4)-(N-acetyl-beta-D-glucosaminyl)}(N+1).	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	527	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.68	0.70	-6.12	10	1072	2012-10-03 05:28:31	2003-04-07 12:59:11	10	35	361	0	640	3978	47	331.20	28	34.17	CHANGED	ssshlacslssQPhs-apsaGasLtHTIClVTCYSEuEEGLRsTLDSlAsTDYPsSHKLLlVICDGlIpGuGND+oTP-IVLsMMcDhlsPs--lEPhSYVAVAsGsKRHNMAKVYAGaY-Yss.......pls.ppQQRVPhlVVVKCGTPsEsottKPGNRGKRDSQlILMsFLpKVhFDERMTsLEaEha+sIWplTGlsP-FYEhVLMVDADTKVaPDSLT+MVAsMl+DPpIMGLCGETKIANKcsSWVThIQVFEYYISHHhoKAFESlFGGVTCLPGCFoMYRIKAsKGspshWVPILssPDIVE+YSENVVDTLH+KNLLLLGEDRYLTTLMLKTFPKRKphFVPpAtCKTlsPDoFpVLLSQRRRWINSTVHNLhELVLl+DLCGTFCFSMQFVVFIELlGTlVLPAAIsFTlYlIlhulls...pPsPhIsLlLLAhILGLPAILIllTsR+WsYluWMllYLLALPlWNFVLPuYAaW+FDDFSWGsTRpVpGEct..KcstscsEGcFDsSpIsMKRWcEaERE	........................................................................................................................................................s...................................................................................................................................................................................................................................................................................................................................hllhlDuDs.h...p....u....lphhlt.....h...........p..s.....p..l......huhCG.....p.........h.....t......l.............t..........s.........t.............t......p.......u....h........h.......s.......h....h...............Q....a.....EYh.lua..hh.t..K.uhEu.hh.G.s.VhCh.P.G.CFshaRhps..................t..............................................................t...t.l.h..........p...p...Y...s..p.................s.....-......s.....h..a....h............p.h.........h.........................h..G.....E...DRa..L....o.o....L....hl..p....t..........t....hp....hp.......a....sspAhshThsPc....sap..............hhsQRRRW....h.s........S...T....l....p..N.....h.....h......-........L.......h....h........h........t...p........h.......p.....h.......h........h....p....h.s..h..............h...l...l........h..h.....p....l...h....u.....s....h...lh.......P...s......s...h..h......h.......h...h.....h......h........................h..........h........h.ht.............t.............h..............h.......h........s...h..........h.........h....l...s..h..h.......h..s.....l......h....h.......h..h....h....h.......h...................t...p.h.....h...h...h.....h......h..h......h....h.h...................................................................................................................................................................................................................................................................................................	0	272	404	566
+1536	PF03503	Chlam_OMP3		Chlamydia cysteine-rich outer membrane protein 3	PRINTS, Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	62.80	62.80	17.80	16.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.44	0.72	-3.75	3	38	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	37	0	4	13	0	53.30	81	60.81	CHANGED	CGVVSLSSCCRIVDCCFEDPCAPpsCNPCEs.+KKD+ssGCNuCGoYVPSCSKPCG	.CuVVSLSSCCRIVDCCFEDPCA.PhpCsPCEu.+KKDVssGCNSCsuYVPuC.KPCG	0	1	1	3
+1537	PF03504	Chlam_OMP6		Chlamydia cysteine-rich outer membrane protein 6	PRINTS, Griffiths-Jones SR	anon	PRINTS	Family	\N	27.20	27.20	27.50	31.00	26.80	27.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.32	0.72	-3.73	2	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	44	0	5	50	0	91.30	82	20.13	CHANGED	CaG+MYsV+VNDDpNVEIoQAVPEYATVGSPYPIEIhAsGK+DCVsVlITQQLPCEsEFVpSDPATTPTuDuKLlWpIDpLGQGEKsKITVWVKP	.........CaG+MYoV+VNDDpNVEIoQuVPEYATVGSPYPIEIhAsGK+DCVsVlITQQLPCEAEFVpSDPATTPTuDGKLlWKIDRLGQGEKsKITVWVKP.	0	2	2	4
+1538	PF01308	Chlam_OMP	Chlamydia_OMP; 	Chlamydia major outer membrane protein	Finn RD, Bateman A	anon	Pfam-B_1429 (release 3.0)	Family	The major outer membrane protein of Chlamydia contains four symmetrically spaced variable domains (VDs I to IV).  This protein is believed to be an integral part to the pathogenesis, possibly adhesion. Along with the lipopolysaccharide, the major out membrane  protein (MOMP) makes up the surface of the elementary body cell.   The MOMP is the protein used to determine the different serotypes.	19.60	19.60	19.70	20.10	18.50	19.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.33	0.70	-5.86	4	1235	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	64	0	7	951	0	269.70	66	99.06	CHANGED	MKKLLKSALL.AA.huSsuSLQALPVGNPAEPSLLIDGTlWEGhuGDPCDPCuTWCDAISlRsGaYGDYVFDRVLKsDVsKpFp.MGAsPTusssA....s.oTss-RPNPAYGKHhpDAEWFTNAualALNIWDRFDVFCTLGAosGYhKGNSuuFNLVGLhGlKGoSl...sAsplPNsulopGVVELYTDTTFSWSVGARGALWECGCATLGAEFQYAQSKPKVEELNVlsNsAQFoVpKP+GYhGssFPLPloAGT-sATu..TKsATIsYHEWQVGhALSYRLNMLVPYIGVpWSRATFDADsIRIAQPKLAsAlLNLTTWNPTLLGpuTslsoo.NcFADhhQIVSlQINKhKSRKACGVuVGATLlDADKWulTuEsRLINERAAHlsAQFRF	....................................................................................RhGaYGDaVFDRVLcs.D.VsppFp.MGtt.P..o..s.s..s..sus...s.oo..h..ssR.NPAYG+HMQDAEMFTNAAhMALNIWDRFDVFCTLGAooGYLK.GN.SASFNLVGLFG..sst..p..s.s.....tss....plPNhulsQ...uVVELYTDToFuWSVGARAALWECGCATLGApFQYAQSKPKVEELNVLsNsApFTIpKPKGYVG..t..p..FPLsloAGT-s..ATs.....TKsAoIcYHEWQsuLALSYRLNMhsPYIGVpWSRASFDADTIRIAQPK.Ap..s............lhshTThNPTlhGt..us.s..h..s......s.....s.....s.hsD...........................................................................	0	4	4	6
+1539	PF00504	Chloroa_b-bind	chloroa_b-bind;	Chlorophyll A-B binding protein	Finn RD, Bateman A	anon	Pfam-B_54 (release 1.0) & Pfam-B_5772 (Release 7.5)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.63	0.71	-3.97	157	2672	2009-01-15 18:05:59	2003-04-07 12:59:11	16	22	422	33	911	2617	772	131.40	25	66.18	CHANGED	hPstL.sG....ph...sG-hG........FDPLGLu...t.-s.......................................................thchhRpuElhHGRhAMLuslGhlssEhh.t.........sh.....t.Ps....ahp.ss..............................................h.s......h...hh...lhhhuhhEhhp.tshhs..t.t.........................hhPG..s...............h.FDPl....G.hs.........ts.pphtph+hpElpNGRLAMlAhhGhhsQth	......................................................................................t.......aDsh.t.h.....t...................................................................thth...ptsElhpuR...hAMLGh.h.GhlhsEhhst................s.........t.............hht...s.................................................h...hh......hh.hhuh.h..E..h..h..t..t.h...................................................hPG..s..........................hssh........s.hs..........p.....t....tht.hphtElpNGRLA.Mhuhhuhhhp..h....................................................	0	418	719	840
+1540	PF02962	CHMI		5-carboxymethyl-2-hydroxymuconate isomerase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.30	21.30	21.40	21.40	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.57	0.71	-4.00	3	831	2012-10-01 20:38:22	2003-04-07 12:59:11	10	4	769	15	152	460	70	119.90	39	95.22	CHANGED	PHFhlECTDNIREpuDLP-LFuKVNssLAAo.GIFPlGGIRSRAHWLDTWQMADGQH.DYAFVHMTLKIGAGRSLESRQ-sGDMLFsLIKsHFAALMESRhLALSFEI-ELHPTLNaKQNNVHALF	.........................................PHhlhEhosNlc-ps.cls.s.Lh.pplspsLh......s......o.....G........lFP.l.u.G..IRSRAhh.h-..sap..h...A..DG.........pp....-hAFlHhoL+IGuGRShEs+pplu-t.LFsllps.+.h.As.l.htp+.h.lALShEltEhc...s.h.sa..Kp.NslH......................................	0	18	59	108
+1541	PF04428	Choline_kin_N		Choline kinase N terminus	Kerrison ND	anon	DOMO:DM04048;	Family	Found N terminal to choline/ethanolamine kinase regions (Pfam:PF01633) in some plant and fungal choline kinase enzymes (EC:2.7.1.32).  This region is only found in some members of the choline kinase family, and is therefore unlikely to contribute to catalysis.	20.40	20.40	20.40	21.00	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.53	0.72	-4.50	21	146	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	123	0	97	147	1	62.40	31	9.87	CHANGED	sshtsut.h..s...sp..LD.shs..h............................h+p-lhpllpoLplssWtcls.-tss	................t....ss.ph.lPs..scshLDNShshsY.................................FKp-IlcLh+oLclpuW++ls.p...t....	0	16	47	78
+1542	PF01633	Choline_kinase		Choline/ethanolamine kinase	Bateman A	anon	Pfam-B_1165 (release 4.1)	Family	Choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway [1]. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family. 	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.44	0.70	-4.76	38	1798	2012-10-02 22:05:25	2003-04-07 12:59:11	15	27	951	30	795	4525	1654	199.50	21	51.55	CHANGED	pspplLlRlYGps..s.................chhhsRppEhhshphlucpulGPcLhGhFssGRlE..cFl.sucsLssp-lpssclpttIApphtchHslsh.........................................................hpcpstlapphcca.......................h..pphspppthpthshppLpcElstlcchl.p...............thcps...lVFCHNDLt.uNllh......................................................................psspplhlIDaEYuuaN.tuaDlANHFsEhshshp..t...ahh..chshaPspcp	.............................................................................................................................................................................................t..pthllR.h..h.Gtt....s......................................phh...l.sR..p.p.....Ehh.sh...thl.t.p........hs...h...s......s.........p..h...h..........h..........h....................p........u...t......hp...........ca.....l...p............u............p...s....L..s..s.......p....p...l.......p....p.............t......h....h........p.....t.....l...A....p.t....h......tph.H....s....h.th..........................................................................................................h.p.t...t......t.h.a..p..p......h...p..c..a...............................................................t..t......t.....t...p...t...t..h..........h......h.......p......h....p...p.....l....p.....p...p.l......t.....p...l...c..p....hl...p......................................p..h.t..t.s............hs...hC...H..N..D..........lh....t.Nllh...................................................................................................................................p..p..p.....s.....p....l....h......l...I...D.a...EY..uu..hN.......saD..l..u...s..a........h...h...Eh.t...hs...t..............h.................................................................................................................................	1	255	439	638
+1543	PF04345	Chor_lyase		Chorismate lyase	Mifsud W	anon	COG3161	Family	Chorismate lyase catalyses the first step in ubiquinone synthesis, i.e. the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate.	21.00	21.00	21.30	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.93	0.71	-4.82	3	1188	2012-10-01 19:33:20	2003-04-07 12:59:11	8	2	1158	11	198	690	245	159.80	37	92.75	CHANGED	hLsNATWQpuDDlp.luPulpsWLh-pGSLTRRLssts-.clsV-lLuEuWh...TLpsDEsQtLsscpusssWlREVIL+GcDpPWVFARTLIPRSSLcsQsFDLsQLGsRuLGEhLFSsSshcRssLEVs+scss.......htuLaARRSRhShGAcsMLVAELFL.TPpIao+ssl	.............................................hhh.......................h........lt.s.t...l..h.-WLh..psShT+Rhcpp.s.p...pl.oVp.......hlpEsas...............p......sp..s.Ep.h.L...hs.p.....ps..............h..W.l.REllLpu..D.u..p.P..Wl..huRTll.P.hooL...............pG.s.t...h.s.L.p...cLGppPLGc.h.LF......os.s..s..ls...R...Dhl..-..l...u+ss...............................tL.W.u.RRS+h.ch.s....G....c....P...LL.lTElFL.tssla..................................................	0	34	86	143
+1544	PF01723	Chorion_1	Chorion; 	Chorion protein	Bashton M, Bateman A	anon	Pfam-B_1914 (release 4.1)	Family	This family consists of the chorion superfamily proteins classes A, B, CA, CB and high-cysteine HCB from silk,  gypsy and polyphemus moths. The chorion proteins make up the moths egg shell a complex extracellular structure [2].	20.90	20.90	20.90	21.80	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.54	0.71	-4.39	14	91	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	6	0	62	96	0	136.40	30	89.51	CHANGED	huphlLhlsspALhsQoshSQChuR....luu.t.....Gh.GhsuLG.YpGhGh.sh....GhG.Ghts.h.usus...LsAshGGsLsVso.ousAPTGLul..sSENsY....EGsVuVsGpLPFLGTssVAGphPTuGhGulpYu...CGDGAVuIouEsuh......uhs.s.shs.s.h.us.s.uhu......hGYtshs.GCGC.........Gs	.................................................................s.......h.h.shhhp.hhuph.........h..........................s..s...s.......hs.......Ghuh............uhu...................................htus.G..s........l.s..sshuPsGlsh..tups.th.................-GsluVsGpLPhhGossltGphPs.GhGsVpau...CusGsVuIsscss...............shs..h.......................................................h.............................	1	39	62	62
+1545	PF03964	Chorion_2		Chorion family 2	Finn RD	anon	DOMO_DM03001	Family	The chorion genes of Drosophila are amplified in  response to developmental signals in the follicle  cells of the ovary[1]. 	21.90	21.90	26.90	26.90	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.80	0.72	-3.46	14	51	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	21	0	18	55	1	106.00	35	72.01	CHANGED	GYGusshG...s.u...psh.p................Ytt...........................s+G.ttuYGpt........................t.hhu.sssspAtutAt.u.AussuGs.p.hthPs.cltsu.hGPph.Ga.........G......hGtst	.................GYGusshG....GYuh.spsshp.hsh................uYGs...........................upG...suYGps..........................t.htu.sssupAhAhAphAhAAsssGs.h.at.Pshclpsu..hGPp.ua........h.G...h....t....	0	4	4	13
+1546	PF00425	Chorismate_bind	chorismate_bind; 	chorismate binding enzyme	Finn RD, Kerrison ND	anon	Pfam-B_164 (release 1.0)	Family	This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.	20.50	20.50	20.50	20.60	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.53	0.70	-5.06	163	11419	2009-01-15 18:05:59	2003-04-07 12:59:11	13	52	4438	63	2457	8400	4662	249.70	32	53.38	CHANGED	spppatptlppshpt.I..psG-...hhpls...Lopphphp..t..ths......s.........hslhppLpp......p.ssssashhh.............ph...................................h..luuSPEhhl.................p..hc................plpopPluGT...t.....R....uts.t.........................p......DtthtppLhpspK-psEphhlVDhlRscLuplt....s....so...........lplsphhplpp....hsslhHLsoplpu.pL.pts.hsh..h-llpulaPsuulsGsPKtpAhph....IpclEs.h.......sRGh.YsGslGals..su.....s......s-hslsIRoshh....ps...........hplhuGuGIVtcSssppEapEsttK	.......................................................................s.pppatptlpps.p.ch.I..p..p..G.-........hapVl.lop..phphp....h........hs....................s...........................................hsh.a.pp.....Lpp......t..Nsu.sYhaah............phss...............................................htl..lGuSPEhhl................................c....hc...st...............plpopPlAGT...t...sR...........u.t.s..s..p.............................p.....Dppht.pcL..hsstK...............-puEphMlVDLhRNDl.u+ls.......suo................lcV..s..chhplcp.....a.sp....VhH.......LsS.plpG....p...............L......pt....s....hss..................hc.hl.p.u.ha.PsG...oloGAPK.hcA.h.......pl.I.p.c.l.Es...t............pRGh..YuGulGalsh.....sG.......................s..............h-hslsIRohhl...cs....................................spshltAG.u.GIVhD.SsPpsEapEottK.............................	0	741	1558	2097
+1547	PF01817	CM_2	Chorismate_mut; 	Chorismate mutase type II	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.53	0.72	-3.89	101	5974	2009-01-15 18:05:59	2003-04-07 12:59:11	16	36	4103	55	1304	3816	1745	78.70	27	28.68	CHANGED	RppIDplDcpllpLLscRhplstpluchKppp.....shs.lhcs.pREppllcplhptsc....tshs..sphlpplappIhctuhthppsh	........RppIDplDppllpLLscRhclspcVuchKtpp............shs..lh.cs...pREpplL..pcltptuc........ttsls...schlppl...applhctShthpp..h.............................	0	373	798	1089
+1548	PF01264	Chorismate_synt	Chorismate_synth;	Chorismate synthase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.00	21.00	24.20	24.00	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.01	0.70	-5.96	158	4715	2009-01-15 18:05:59	2003-04-07 12:59:11	16	5	4374	29	1174	3448	3602	336.60	44	93.20	CHANGED	hRhoTaGESHG.ulGsllDGhPAGltlspccIpt-LsRR+..PGt...u+.hso.RpEsDpVcILSGVh.cG......hTsGoPIullIpN....pDh+stcY..........................schtst.RPGHADhshthKY.G..h+DhRGG.GRuSARETAuRVAAGAlA+plLp...phG.....IclhualhplGsh........................phshp.h.......cp......ss..lhssDspstpchtphIcp.s+cpGDSlGGll-llspG......lPsGLGpPl.aD.KLDAcLApAlMSIsAlKGVEIG..sGFpsuphhGSpspDph......hhpst.............hh.pp....oNcuGGl.GGISsGpsIllRsAhKPssolhp.stpTVs.pstc..psplphtGRHDsCllPRAssVsEAMlAllLADthLc	..................................hRhoThGESHG.uLssll-GsPsGltl.stt-..Ipp-.LcRR+sG..t......uR...h.so.RtEs..DpVcILSGVh..cG..........h.T....T.GoPIulllpN...pDp+s...t-Y..................................................................................sp.h..h.st..R.PGHADhshthKY.G..h.R..DhRGu..GRSSARETAhRVAAGAlAKphLt...p......h.G.............lcltualsplGsl.....php........................................................hhs.hp.pl......cp......ss.hhss...D.....ssttpphcphlcp.h+.+.pGDSlGuhlpllspG......lPsG.LGpsV..aD..+LDAclApAlMSINAlKGVElG..sGFpss.phpGSpspDEh.................hh.s.st...............................htoN+uGGl.GGlS............sGp......sIls+hAhKPhsolhp..P.hpols.pssE......pspl..hpGRaDPCls.RAsslsEAMlAlVLhDtlLp......................................	0	394	771	1014
+1549	PF02417	Chromate_transp		Chromate transporter	Bateman A	anon	Pfam-B_1872 (release 5.4)	Family	Members of this family probably act as chromate transporters [1,2].  Members of this family are found in both bacteria and archaebacteria.  The proteins are composed of one or two copies of this region. The alignment contains two conserved motifs, FGG and PGP.	28.60	28.60	28.70	28.60	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.96	0.71	-4.66	103	4595	2009-09-10 17:38:28	2003-04-07 12:59:11	10	9	1631	0	1528	4268	786	171.40	25	85.64	CHANGED	shhpLFh..hFh.plGhhuFGGuhuhlshhccphV.cppcWlopcpFhchlAluQhhPGPhslphushlGa+...h......sGhhG........ulsAsluh...hlPuhllllhluhhhtp..hpp..tshhpshhpGlpssslullhssu.....hph.sps.............hhtsh..hshhlh.shs..hlhlhhhp....h.....sslh.lllhushhGhh	...................h.hhplFh.hFh.+lGhhsFGGuhuhlshhp..p..phV....p..............p............h...p..........W....lo.......p...ppFh.chlAluQhhPGPh..sh...phu...sa....lGat.......h................sGhh.G.........................................................ullAsluh...........hLPuhllllhl.uhhhpp.........hpp......ps..h.....l.p.uhhpGlpsu.llullhsus......................hp.h.spp................................shtsh....hsh.s....ls....shs.....h..l.h...l......h.h..h.p..........l..........s.hh...lllhuulhGh.............................................................................	0	510	999	1289
+1550	PF00385	Chromo	chromo; 	Chromo (CHRromatin Organisation MOdifier) domain	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.93	0.72	-4.29	173	5794	2012-10-02 16:56:36	2003-04-07 12:59:11	19	330	405	83	3614	5547	121	53.30	24	6.52	CHANGED	htl-cIl..cp+..hpcptt..................paLV+Wpu.hs....pcs.TWEs..tc.slppp.....p...lptatpp	..........................................l-cll...spc........htctpt.......................................pYhVKWcu..as.............pcs..TWEs...cc..plptt.......ph...lpta..........................	1	1222	1720	2571
+1551	PF01393	Chromo_shadow		Chromo shadow domain	Bateman A	anon	Medline:95396576	Domain	This domain is distantly related to Pfam:PF00385. This domain is always found in association with a chromo domain.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.74	0.72	-4.13	8	489	2012-10-02 16:56:36	2003-04-07 12:59:11	14	9	177	24	286	474	0	56.80	49	28.14	CHANGED	RGLEPE+IIGATDSs.....G-LMFLMKWKsoDEADLV.AKEANhKCPQlVIuFYEERLTWHS	.......................RGL-PE+IlG.A.T.Do.s..............G-..L..h..FLhKW.KssD....c...AD..LVsA+pANhKCPQl.VIpFYEE.RLoW+........	0	69	99	194
+1552	PF00878	CIMR	CIMR_repeat;	Cation-independent mannose-6-phosphate receptor repeat	Bateman A	anon	Pfam-B_764 (release 3.0)	Family	The cation-independent mannose-6-phosphate receptor contains 15 copies of a repeat.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.17	0.71	-4.43	12	1464	2012-10-02 14:19:21	2003-04-07 12:59:11	13	33	108	57	767	1357	0	136.00	23	77.56	CHANGED	shpcsosIpFhCNcssh.s...sPVFhtEs......sCoYaFEWcTthACs...hpslpCplpDstu.pcYDLSuLo+tsc...sWcAVDsots.t.++pFaINVC+....hstspuCP.ssuusChVsc.spShNLGhhtpuPpht.sGslpLpYssGDhCs	....................................th...hsohIpFhCsps..s....u.............pP.h.h.h...p..ps..........sCpahFpWpTshA.C...............s...................p..........sh..............s................Cp...l.........p.......c....s.p.......t....p.p.aDLo...s.Ls...ptpt.............s.a.s..h.....ss....t......tt........................t...ahlNl.Ct...............................s......t.....s.....t.....s....C.....s....ts...u.....usC........h......p..........t.......s..........p..........s..........h..........s......l......G.h.....h...p.....p....t...............ph.....ss............l....l.Y..sGp.C........................................................................................	0	238	267	463
+1553	PF02464	CinA		Competence-damaged protein	Mian N, Bateman A	anon	Pfam-B_2197 (release 5.4)	Family	CinA is the first gene in the competence-inducible (cin) operon, and is thought to be specifically required at some  stage in the process of transformation [1]. This Pfam family  consists of putative competence-damaged proteins from the  cin operon.	20.90	20.90	20.90	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.55	0.71	-4.77	102	4443	2009-09-13 17:09:44	2003-04-07 12:59:11	12	14	3786	2	995	3093	2194	153.50	36	58.87	CHANGED	tpsLsptlsphL.tppsholusAESCTGGhluutLTslsGuSshFpGGhVsYoscsKpplLGVspphLppaGAVScpsAptMApGs.pptht.....uDhulu.lTGlAGPs.GuotpKPVGpValuluttst.......stsp.chpFsG.sRpp..lRppusptALphLhchL	................h.pLsptlsphL..ppcshslusAESCTGGhlAusloslsGu.SshFcsGhVT.Y.Ss.cs.KtphLuVs...t...p...sLp...p....a...G..A..VSc.tsAtpMAp.GA..h.pt.s.p....................uD..hulu.lTGl..AG..P...s......G.............u............s....c...t+.......PV......G.T.Vah.uhu.....tpss.................shs....p..p.h..........p..a.......s..........G.....s......Rpp..lRppusthALphLhp...................................................	1	323	652	857
+1554	PF04162	Gyro_capsid	Circo_coat; 	Gyrovirus capsid protein (VP1)	Bateman A	anon	Pfam-B_1772 (release 7.3)	Family	Gyroviruses are small circular single stranded viruses. This family includes the VP1 protein from the chicken anaemia virus which is the viral capsid protein.	25.00	25.00	95.40	95.30	21.30	17.40	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.74	0.70	-6.24	22	315	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	11	0	0	241	0	348.00	94	99.88	CHANGED	MARRARRPRGRFYAFRRGRWHHLKRLRRRYKFRHRRRQRYRRRAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGVIFLTEGLILPKNSTAGGYADHMYGARVAKISVNLKEFLLASMNLTYVSKlGGPIAGELIADGSKSQAAENWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPVASLLSQGEYLTRRDDVKYSSDHQNRWRKGpQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITuTTAQGTQVRCMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMuAPASELDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDAWAVVRVQSVWQLGNRQRPYPWDVNWANSTMYWGoQP	.MAR.RARRPRGRFYAFRRGRWHHLKRLRRR.Y....KFRHRRRQRYRR.....RAFRKAFHNPRPGTYSVRLPNPQSTMTIRFQGlIFLTEGLILPKNSTAGGYADHhYGARVAKISVNLKEFLLASMNLTYVSKIGGPIAGELIADGSp...SQAAp....NWPNCWLPLDNNVPSATPSAWWRWALMMMQPTDSCRFFNHPKQMTLQDMGRMFGGWHLFRHIETRFQLLATKNEGSFSPV..ASLLSQGEYLTRRDDV.KYSSDHQNRWRKGcQPMTGGIAYATGKMRPDEQQYPAMPPDPPIITsTTsQGTQV.....R.........CMNSTQAWWSWDTYMSFATLTALGAQWSFPPGQRSVSRRSFNHHKARGAGDPKGQRWHTLVPLGTETITDSYMsAPASElDTNFFTLYVAQGTNKSQQYKFGTATYALKEPVMKSDuWAVVRVQSVWQLGNRQRP................................	0	0	0	0
+1555	PF02443	Circo_capsid	Circo_ORF2; 	Circovirus capsid protein	Bateman A	anon	Pfam-B_1890 (release 5.4)	Family	Circoviruses are small circular single stranded viruses.  This family is the capsid protein from viruses such as porcine circovirus [1] and beak and feather disease virus Swiss:Q9YUC8. These proteins are about 220 amino acids long.	25.00	25.00	25.00	30.20	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-4.99	12	1556	2012-10-04 01:49:40	2003-04-07 12:59:11	10	1	51	1	0	1258	0	196.30	62	95.87	CHANGED	phphRRRhtRs......hhRRRahRt......RhR.RRh.hpRRtapsNRlYshRlsRpaphplp.ptoss.ushpWssDhlshsLsDFL.ss........................sssshpLPFEcYRI+LAKhEh+Pths.hs.p.cGhGpTslIpDu+lpcFpppsshs.DPLAsaDGA+pW..p+GF.KRLh+PKPQl..oIsDhssu.NpoAALWLsss+shWIPl.....p.hs.suts+VcHYGlAaSa.pP.tss.....hsYpsplTlYVpFRQFsh	..............................R.R.RhtR...........hhRRR.hhh......RY..R.hR..R+.................N.tIashRLp.RTFGYTlK...pTTVpTPSWAVDMMRFNIsDFLPPG.......................GGoNPhSlPFEYYRIRKVKVEFWPCSPITQ.....GDRGVGS.oAV..ILDDNFV..TKATAL....TYDPYVNYSSRHTIsQPF.S.YHSRYFTPKPV.LDpTIDYFQPN.NKRNQL.WLRLQTs........................sNVDHVG.LGT....AFENS..hc......pYshclThYVQFRpFs...............................................	0	0	0	0
+1558	PF04487	CITED		CITED	Finn RD	anon	Pfam-B_3987 (release 7.5)	Family	CITED, CBP/p300-interacting transactivator with ED-rich tail,  are characterised by a conserved 32-amino acid sequence at  the C-terminus. CITED proteins do not bind DNA directly  and are thought to function as transcriptional co-activators [1]. 	21.10	21.10	24.90	21.80	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.69	0.70	-4.11	11	168	2009-09-11 10:42:53	2003-04-07 12:59:11	7	2	46	2	72	157	0	163.30	35	97.93	CHANGED	MA-H.MhAhsauhhssshtt......hphsMs.....u.stps.+s......hps....uslhHYuuu...uhcuuhtsRsu...........sG.shuhupPsus..s.hhas........................ss.p.p.Fh.....ssuspLhASMpLQKLNopY.G+............tsts......sGtPhssus.Q...aR........sGsu.ssuhpp..ss..hs.ulhDsDhIDEEVLhSLVlELGLDRlpELPELaLGQNEFDFhoDFsst.tsupVSC	........................................Msph.h.shsht.hsts.tt......hp.t.Ms...th.s.sp.ht.pt........hps....sthhHYsus...shpu.s.t.p.ts...................u.s.sh.s....P.t.t.............................................s......a......t.s.pL.ASMpLQKLNspY.sh................................................hts.....sup.htsss.p.................t................................................u.......s.sssh.t...................shhDsD.lDEEVLhSLVlEhGLDR....hpELPELaLGQNEF.DFhsDhss............................	0	6	14	28
+1559	PF04223	CitF		Citrate lyase, alpha subunit (CitF)	Mifsud W	anon	COG3051	Family	In citrate-utilising prokaryotes, citrate lyase EC:4.1.3.6 cleaves intracellular citrate into acetate and oxaloacetate, and is organised as a functional complex consisting of alpha, beta, and gamma subunits. The gamma subunit serves as an acyl carrier protein (ACP), and has a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group. The citrate lyase is active only if this prosthetic group is acetylated; this acetylation is catalysed by an acetate:SH-citrate lyase ligase. The alpha subunit substitutes citryl for the acetyl group to form citryl-S-ACP. The beta subunit completes the reaction by cleaving the citryl to yield oxaloacetate and (regenerated) acetyl-S-ACP. This family represents the alpha subunit EC:2.8.3.10.	19.50	19.50	19.50	19.60	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.52	0.70	-5.82	5	1131	2012-10-04 00:26:15	2003-04-07 12:59:11	7	4	925	4	116	1121	28	448.90	64	91.35	CHANGED	DRKLsuSLEEAIc+oGLKDGMTISFHHAFRGGDalVNMVM-lIA-MGFKNLTLASSSLossH.sPLVEHIKNGVVT+IYSSGLRGsLA-sIS+GLLcEPVpIHSHGGRVHLIpSGEL+IDVAFLGVPsCDEFGNANGacGKAsCGSLGYAhVDA-YADpVVhLTEsLVsYPNsPASIsQDQVDhVVpVDAVGDPsKIGuGATRMTTNPRELLIA+pAA-VIsNSGYFK-GFShQTGTGGASLAVTRFL+EKMl+cNI+AoFALGGITAoMVDLHEcGLI-KLLDVQsFDSsAApSLARNPNHlEISANpYANPuSKGAuVDRLDVVILSALEIDTpFNVNVlTGSDGVIRGASGGHCDTAuAApLSIIVAPLVRGRIPTVV-cVsTVITPGoSVDVLVTDpGIAVNPsRPDLl-+Lpcss.lPVaoIEpLpERActlTGKPcPIEFTDKVVAlV+YRDGSlIDVV+QV	............................................................................................................................................................................................+KlsuSLEEAI++SGLcDGMTlSFHHAFRuGDhslNhVM-.hIA.cMGaKNLTLASSSLsssH.sP.LlEHI+sGVVopIYTSGLR.G.LuEpIS..c..G.LLt.pPVpIHSHGGRV+LlpSGELpIDVAFLGVPoCDEFGN..AN..G......h....s....G....K....u....sCG.SLGYAhVDAc.AcpVVhLTEpLlPYPp.sP.ASIsQDQVDhlVpVDc.VGD..ssKIuuGATRhToNPRELLIA+pAA-VIspSGYFK-GFShQTGTGGASLAVTRFLc-KM...cp+sIpAsFALGGITuoMVDLHEcGLI.......+.........KL...L.D..V......Qs.........FDp.sAAp..SLAcN.P.s...H...l...E...I..SAN.....p.Y........A........N.........uSKGAuV-..+LD.V.V.lL.S.A.L.EIDT..pF..NV.N..V..l.TGSDGV.lR.GASGGHsDTAhu.ut.....L.....S.......I....I.l..A..P..L..V..R..G.R.IPTlV-...pV...h...T.slT.PGuSVDlLVTD+GI.....A....VNPs...R...s...-LhEpLp.p.AG..l.lho..IE.L+-RAphLT.G.cPp..P..IEF.T.D...R...VVAVV+YRDGSVIDVV+QV..............................................................	2	32	62	87
+1560	PF01874	CitG		ATP:dephospho-CoA triphosphoribosyl transferase 	Bott M, Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The citG gene is found in a gene cluster with citrate lyase subunits [1].  The function of the CitG protein was elucidated as ATP:dephospho-CoA triphosphoribosyl transferase [2-3].	20.80	20.80	22.20	21.10	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.47	0.70	-5.20	135	1741	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	1304	3	316	1196	72	248.10	35	85.49	CHANGED	pl....uphAhpAhhhElsh.PKPGLVchtssGuH.DMshtpFhp.Suhultshhtphspsuht...t..........ltplGhpAEpsMhtsTsGlNTH+GulahlGlLssAsut................................h.tttsstsstthhtslsthssshh.....t..............t........tpshohGpththpauhsGsptEstsGFstlhphulPthppsh..t................hs.ppAhlpshltlhuph.sDTsll+RuGhpsl.phlpppAppl....Lstu.............t.tt..hpplpph-pthh..pcslSPGGoADLLusolFlst	..............................................................................h....huhpAhlhElploPKPGLVDthssGAH.p.DMslt.sFhp.Suhult.sah.phhphGhptsth.........................hhttlR.lG..htsEtsMhpATsGlN..T...H+GuIFulGLLsuAhut..............................................hht..t.p.shs...pplspth.sp.hs.pslst................................h.tp.....ttphTtGpphhpphGls.....Gs....RGEApuGashVhptALPhhpphh..pp...............................ths.chAllpsLLh.LMuh..sDTNlhpR.u.G...t..uL..pa.lQp.pAppl....LtpG.................Gh.hs.ss.....hptLpphDcthl..c+s..lSPGGoADLLhhThFls.p............................................	0	62	165	244
+1561	PF03600	CitMHS		Citrate transporter	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Family	\N	29.60	29.60	29.60	29.60	29.50	29.50	hmmbuild  -o /dev/null --hand HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.34	0.70	-5.87	32	7280	2012-10-02 15:12:49	2003-04-07 12:59:11	11	35	3249	0	1836	11155	2469	359.10	15	84.92	CHANGED	Luhhhslshhh..llhhpthuslhuhhllsllhsLh..............................hs.hh.phlshls..slhLLFuhha.hslM.-oGlFDslsphlhchspGc.hclhhsssllsullShsGsusTsshlss.shhl.Lacphsls.hhlssslsluuslhs.hsPhGsPss........ps.hsslsh...sshhsshlPuhlsulhhhh...hhhhhhth+cppthtthph.htt..............................................................................................................................................................................tpshtptpsptttht+shlhhhshhLshslhshl.............................lhuh............h.s.lhhhhuhslsllhsa.slcpphp...th.ttstsshsslhhhhAhhlFsullstsuhhctluptlhsl............lstslu.hlsllsuls.ShPhshhhu.ps....hhslhhpsusthGls.h.hshsuslGs	.......................................................................................................................h..h.h.h.......h..h.......................h.....s....h....h...h...h..h....h..h..h..s..h.hh.shh..........................................................h...h..t..p....h...h....s...t...h....s...............s.............l..........h...h..l........h...u..h..h....h...st.h...h.p.p...o.Gh...hp...hls....p...h...l...l....p....h..s.....t......s......p......................p.........l...h..h...h...l......h......l.........h...s...u..l..l..o.s.h.h......s...s.s...s.....s...s...h........l.....h....l.....P..l...s............l.......s....l...........t.............p..............p...........h...............p...........h.............s..........s.................t..............h...............h...h..h....s....l....s.....h......u..u........s..h....u.u.h.....h....T.......l...G...s...P..s.....s...h..h.l........................................ts...hts.h.s...h.................s...s....h.....h......t...h.....h....h....s...h........h...l...h...s...h..hh...hh.........hhh.h.hh.h.pp.tt.t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...h.t.h.h..h....h..........h...h..l...h....h...s.h..h.hhh.....................................................hht.h.........................................h.....h...h....h....h...u.....h...h....h.....h.......h........h............h............t........h.................t........h.......p....p...ht.............................................t.....ht.h............hl...h...h.h...h....u.h.....h.h.h...s..t....s....l...t.......t.....h...s........h..h.t.....h..h...s.p.....h.h..th......................h.......h...h..h.................h..h....s..t....h...h..........s.......s..hh.h.....................................................................................................................................................................................................................................................................................................................................................................................................	0	639	1190	1535
+1562	PF00285	Citrate_synt	citrate_synt; 	Citrate synthase	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.30	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.20	0.70	-5.72	121	9392	2009-01-15 18:05:59	2003-04-07 12:59:11	16	26	5081	103	2244	7278	4274	289.30	36	82.11	CHANGED	GL.....psshsspopIohlDG...........ppGh..LhYRGYsIp-Ls.p.pss.............FEEss.aLLlhGc..L.PspppLppFppplttpp.t..........lsp...plh...phlps.hPp.sscPMshLpsulusLus.hp.t..........tstph...p..hcpuhcL.lAphPslsAhh..a+hp......pGtphltPcss..Lua...utNFLhMl..pspt............s.s.....t.hscsh-hhLlLaADH.thNuSTFssRlluSThuDhYuulsAuluuLpGPLHGGANptVhchlpcI....ss...........scpscpalcctlsp.pc..+...lMGFGHRVY+.shDPRApll+chscplstph.........sp....sphhclupplEchshp...h.p+.t...lhPNVDFYSullapth.GlPt..-hFTslFAluRssGWhAHhhEp....h.t.....ss+l.hRP	.......................................................................h.sh.sh.otls.lst...........pts.....LhaRG.hsl.pLs.p..tsp..............................a.-sh.aLLh....G.c...........h.P.s.t.t.p.h...tt.hpttltt....t..............l....t...t.h..........thhtt...h......t....HPMs.h.h.sshsh.lssh......................................................t...tt.....shcl.h....up..hsslh..shh...a.+ht.........................s....h..h......s...p..ts......hshstp.F.lh..hh....h..stt................s..h.cshchhhh.La....A-H..t..............N.s............S.T.T..s...Rl...............s...u.S...............o.t.u.s..a.u.slsuuluu.L...hGPh.HG.G.A.N.Essl.c.MLpcl............ss.....................scpl.ca....l.t.+.t.h.cc....p-........+...................lM..GFGH.RV.....Y...+...shDP..RApl..h+chsc.clhpch..........ts....s..s..lhc.lAhc..lEclshp.......hhc+.+.......LaPN.........VD..........FaSGl....h....h.............ct.h..........G..............h.Pp....p........h..a..............T..............s..............l.FshuRhsGahAphhE.....ht.....t.tl..RP.....................................................................................................	0	694	1359	1866
+1563	PF03802	CitX		Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase	Bateman A	anon	Bateman A	Family	\N	25.00	25.00	26.40	25.60	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.94	0.71	-4.82	29	1055	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	904	0	101	514	3	165.80	43	81.99	CHANGED	pslsL.plLsuREtRsshQpphLpca.pt..sLlSlTlshPGslKsssthcplFstulpslpphhtptthhhhtp....sttTGPEuhhslsts.AtplKphhltlEcsaPLGRLaDlDVl...sspsptlSRpsluh..ssR+CLlCscsA+hCuRuR+HulpElhsplpchlpph..spc	...............................p.sVolsElLsuR-cRtARQ+th....L..p+a..ss...........PLlShTlssPGslKsStlh++lFspulsslpsLstcps.W.phpt.p...............th....lspsoG...PEuhl.uls.uP..Aps..LKtthlpLEcsHPLGRLWDIDVl.............ss-G...chLSRc....-huL..P.sR+CLlCpp.s.AtlCARu+pHsLs-Lls+hctllpshpt.s..........................	0	23	50	75
+1564	PF01214	CK_II_beta		Casein kinase II regulatory subunit	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.10	20.10	22.20	21.10	20.00	17.30	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.35	0.71	-4.78	66	783	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	323	22	504	729	15	179.10	47	69.13	CHANGED	sWIshFssh.hspcaFscV-c-aIpDpFNLhGLppp..lspappALchILDhpstp..................................pthppsp....tptl-psAptLYGLIHARaIlTspGlpt.....Mh-KYpp.ucFGpCPRlhCpsptlLP..lGlSDtsspssVKlYCPpCpDlYpP..ssctsslDGAaFGsoFPphFlhsa.sc..hhspt........................................................................ppahP....+laGF+	..............................................pWIsWFCuh.cG.sEaFCE..VD--YIpDcF.NLs..........GLspp...V.s.h.Yc.............pAL-hILDlps..pp.......................................................t..s.....p.p.......pphl.EpuAchLYGLIHARYIl.T.s+Gltt..M.........h-KYpp.u-.....FG.pCPRVaCp....spshLP........lG...hS.DhP.....sps.sVKlYCP+C.....pDlYhP..po.s..+.....p...tp...l............DGAaFGToFPphhhhsaPp....hhspp.........................................................................................stppahP....+laGF+...........................................	1	212	307	426
+1566	PF03805	CLAG		Cytoadherence-linked asexual protein	Lawson D, Bateman A	anon	Lawson D	Family	Clag (cytoadherence linked asexual gene) is a malaria surface protein which has been shown to be involved in the binding of Plasmodium falciparum infected erythrocytes to host endothelial cells, a process termed cytoadherence. The cytoadherence phenomenon is associated with the sequestration of infected erythrocytes in the blood vessels of the brain, cerebral malaria. Clag is a multi-gene family in Plasmodium falciparum with at least 9 members identified to date.  Orthologous proteins in the rodent malaria species Plasmodium chabaudi (Lawson D Unpubl. obs.) suggest that the gene family is found in other malaria species and may play a more generic role in cytoadherence.	18.30	18.30	19.90	19.80	16.80	16.70	hmmbuild  -o /dev/null HMM SEED	1282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.23	0.70	-14.21	0.70	-7.22	10	213	2009-09-11 00:22:49	2003-04-07 12:59:11	8	2	15	0	39	216	0	436.10	45	84.97	CHANGED	DNIpELKphI-N-ELYcNLspLE+hlLpoLEpDKLKlPlhps-s+.cYlDhSpFKll...cstssucscsYIlPThcoohcDIIKYEHlLKpQlhpcYss-ISDhIK+KlLlVRTLKllKlMLlPhNsYKcssDlKpALpELNclFpsc..ppppcccsslphpschFcpllpsl+tlKcppph.pth......DsKp-lh-hsDhFFTTssNIEFM-sLDpIoNpYGIGlaNhlGsHhIALGHFlsLKLALKpYcpYFEtGslKFaoWQKILpFshSDRFKlLDLMCDcsusYcsppKRRpoYLKscpouoopECNILEFLIHaFNKYQlELlppspcp-FslahhhEHKclK-cFFsFMCs..csKECsIYcospFKpEps--ssFs-pps.sFs........hhuPaNlYsNYaYFhKpYs-FsscpllYlHlLNLsGlLNs-scAYVoSLYLPGYYNAIQLSFp--ppLs-LapNLlKClcKCau.p++spo..p+.pslpsptcp-sSKCslCKGsFhYIN.Ks--ssSMLQKFYsYlTKlLclpplSoLlcshsIY--YsNFLoHDLNWYTFLFLFRlTSYK-IsppoVuEAMYLNLKDEDsh++ThVTsaWYPSslKKaYTLYlRK+lusNLL-ELEpLl+pcTIEKMKKSIpFllHVNSFLQLDFFHtLNEsPlG..RsaPLShlLEs+FK-Wh.shssGFaFlNYDcPptRtcLacKhcsp+FlsPKhscWschLK+lIcsAY-hYFpQRHVKNLaKaHssaNINNKIMLMRDSYELYhKNacDllFhADIhllRKYLouTPKl++lpDRhaYalHslhGNulNFYKYGlIYGFplNKchLKEVV-ELaoIYphNpcIFoDlSFLQTVYLLFRKIEpSatSHRRNDclSlNNIFFhNVusNYSKLsKEER.pEIHsSMASRFauKThFosFQhMFsopIS+clD+LDKhYGKAshlplsssEcAaLpFAYlY.GSIhDSlTNsLhPhYAKKPIsQLKYGKTFIhANYFhLuSplauhLNLNNLShLCEYQAIsSANaYShKKluQFls+KFlPllsYahhhRlts.hspsp...ttaphhpt.us.sp........................hhhpsshYhohYhusNLah-sstaFPssLssELp-QT-alptpp.ccKPslHuhspshlhullpuhshsFslaslspaYAFF-NllFalhsshRFhDRaaslhspYhssah+phh++hTsDllLKhhp+sYpshKKcGYYcEsIsARLssKpplpphltt-pspslhsslp.h-hcshp+.shshYsD-phhF-DlscNEpFLN-R	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................shhpFAYhYsGSIMD.SlTNsLLPPYAKKPITQLKYG+TFVFSNYFMLASphY-MLNYKNLSLLCEYQAVsSANaYSuKKlsQFlGRKahPlTThaLhhRIptohsahp......thphhs..ss............................................hts-sshaLaFaFFhNLYhDuhKaFPGGFusuL+EQTcH.Vppps.....a.+KP.VHths........................................................................................................................................................................................................................	2	14	17	38
+1567	PF01217	Clat_adaptor_s	Clathrin_adapt_s;	Clathrin adaptor complex small chain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.74	0.71	-4.47	7	3187	2012-10-04 00:47:01	2003-04-07 12:59:11	15	38	357	27	2033	2739	18	135.90	25	49.99	CHANGED	hl+hlLlhs+pGchRLsKaY.sshssscc.pKhlcclhtslosRpsch................sNhlEhps..h+llY+pYAsLYFshsl-.s.-sELhhL-lIppFVEsLDphFs.NVCELDllFNFpclahll-Ehl.G.G.lhEoshppllcplt.hspht	..................................................................................hphlhl.h.s.ppGc.h.....hls+hY....t................s...............h...............s......p.....p..........p..........p......p....p....h...h....p...c..h.h....p...h.h.....h......s.+....t..t..p..h.......................................ss.h...l.......p......h......p......s........hph..lY..+.+...............a.s.......sL.a..hsss....s.......s.....ps.s.N.t.L.h...h..........l..-...hlp............p.h.l.-s..l...sc.a..F.........t........s.....l.s.Eh...s.l.h...N.a....h........la...l...........LDEh..l...s...G..h..h................p.Ts.p.lht.h......t..................................................	0	669	1072	1604
+1568	PF00637	Clathrin	Clathrin_repeat; 	Region in Clathrin and VPS	Bateman A	anon	Prosite	Family	Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.47	0.71	-4.59	150	4251	2012-10-11 20:00:59	2003-04-07 12:59:11	15	79	397	51	2715	4128	33	136.90	16	33.12	CHANGED	l.php..shhshspllchhpc...tshhp.lhtaLpphh......s.pt..ppsslpstLhphhhct......sp.pplcphlp..phsp.....aDhtpluphs..ccpc.Lhptthh...lYpc..hsphpchhp...l.hpp.pthppsh..chstctss.....clhppllphhlsptphph	..............................................................h........phppllp...hh.p.......ts..h...h..p.t....Lh..taLpthh....................t...p...........pp.tslpstLhthhhct....................................pp.pplccalp................t.sp.........ach..tp......l.t.phs.......pc....tp...h....hptthh....lapc..........hsphpphlp.......h..hpp......p.....phppsh........ch.ht.c..h...ss....................p...hh.plhth.hp......h.............................................	0	886	1499	2201
+1569	PF01086	Clathrin_lg_ch		Clathrin light chain	Finn RD, Bateman A	anon	Prosite	Family	\N	20.40	20.40	20.50	20.60	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.84	0.70	-4.43	28	493	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	297	6	289	500	3	200.20	27	86.99	CHANGED	MA..DcFPsl-s.sss........s.h..ssptsssu-FLuREcshLGD...pFto-pD.......hs.s-sD.................p.ssFppsFPslsststt.....sussushsGshht.s.......suhsphsphpsE..PEsl+cWRE++ctcIpc+-ctsccp+pEhhcKApccIDDFYpsYNpKp-KppupsR..................t-tE....pFLucR--h.opsGTpWERlAcLlDhssKus+...su+D+oRFRclLlsLKtptpAPGu	............................................................................................................................................................s.........tstFL.tp..ppt..lus..................h.ps..................tss...............................................................t....st..ts.t........................t..ts.s...sut....t..s..........................t.....su..h.....s.t.h...s....p..ppE.....sEslR...cWREcpptcL..p...c..+....Dtppc...........cpctEhhccApccl--.aYpphscph-+s+t.sNR....................................tpE-......tFlppp-c....t.sGo...p..WERlAcLs.....D.....h.ss+ss+............................pspDhSRhRplLlpLK.....psPh...................................................	1	94	157	232
+1570	PF01394	Clathrin_propel		Clathrin propeller repeat	Bateman A	anon	[1]	Repeat	Clathrin is the scaffold protein of the basket-like coat that surrounds coated vesicles.  The soluble assembly unit, a triskelion, contains three heavy chains and three light chains in an extended three-legged structure.  Each leg contains one heavy and one light chain.  The N-terminus of the heavy chain is known as the globular domain, and is composed of seven repeats which form a beta propeller [1].	21.30	21.30	21.90	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.35	0.73	-7.82	0.73	-3.30	71	581	2012-10-11 20:00:59	2003-04-07 12:59:11	15	30	177	39	344	507	4	38.40	30	4.84	CHANGED	sshspphsa.ssh..shhhlhslp.........stuplhlhslc	.....tsst.IsacssscpphhhlhGls.........ststGphplhsV-..	0	90	164	246
+1571	PF03505	Clenterotox		Clostridium enterotoxin	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	32.40	35.10	21.90	16.80	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.18	0.71	-4.92	4	72	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	20	25	4	63	0	172.20	44	58.07	CHANGED	D+DLIGTLLIEusoSGSIIQPRLRNTTcPlFsoSNsTtFSQpYTEtRLcDAFNIpLFNTSTsLFKFVEEAPsNKNIshKsYNTYEKYELIcYpNGsIsscApYYLPSLGasEVosAPSstu.VVch.lspsuFIQsGPpEcIVlGVIsPSENIp.EIsTsIu-sYTYNIPshlssNPhYlLFsVNoTshYKIoscsNL	....................pllGs.lIpsuooG.lhp.pLRsospslhhs.ssspFspEYhcsplpssF.Nhp.hNp.shhFcFscpAPSNKNlhhhl..TY.+YElIch.pssIs-+A.hYlPSLGYscshphsS.tt......lsps...............................................................................................................................	0	2	4	4
+1572	PF03515	Cloacin		Colicin-like bacteriocin tRNase domain	Griffiths-Jones SR	anon	PRINTS	Family	The C-terminal region of colicin-like bacteriocins is either a pore-forming or an endonuclease-like domain. Cloacin and Pyocins have similar structures and activities to the colicins from E coli and the klebicins from Klebsiella spp. Colicins E5 and D cleave the anticodon loops of distinct tRNAs of Escherichia coli both in vivo and in vitro [1]. The full-length molecule has an N-terminal translocation domain and a middle, double alpha-helical region which is receptor-binding [2].	25.00	25.00	37.00	31.60	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.86	0.70	-5.19	8	84	2012-10-01 19:36:59	2003-04-07 12:59:11	9	10	43	12	4	97	0	272.40	34	49.83	CHANGED	Mu......................................psG.sausp.ssa.shtt.s.............GGsspsG..uuoshu.s...................s.hPtshAh.......GlPuhhsPG.......sG........shulSlsus....slsAAlu-lhtsL+G.....stP.....................aKhshsGlulhulhPupIAcDc.sh.................hshlVooLPsDslT-sPlSsLPhspssVsVshRlsDlVcDspQplAlVsu..hPhsVPVVcA+P........TcpssVaoAul.PG.hPslplSVspssssspuhscuhssc......cstsspPAGaThGuso+..-AlIcFPccSGpcP.lYlSVoclLosspl...KQRQ-EEp+tppcWc	................................................G..........s..spG.sausp.ssasshtt.s.............GGsspsG..GuSuhussh...................hsstshAh........h.ulhhPG............tG........GhuVolpus....tlSAAhssl.suL+G...........s.P..........................huVuhhtl.Puphsc.pc.hh........................lhso..h-plT-hPsS..pLPhstssVsVphRlsDhspstpQhhullsG....hP.M.oVPVVDAhP........TphssVaoAsl.Ps.hPsL.lSVsptsssspsss.h.pps.......pstshh.AGaThuuNs+..DsllRFPcsSGhsP.lYlSss-lLssspl...pQRQ-tENptppca...........................................................	0	2	2	4
+1573	PF03513	Cloacin_immun		Cloacin immunity protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	27.90	59.60	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.67	0.72	-3.94	6	22	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	17	7	6	26	1	80.50	54	72.32	CHANGED	GLKLcLsWFDKKTE-FhGcEYSKDFGDDGSVIESLGlPLKDNINNGsFDVccsWVPlLQPaFKNpI-hDKahYpISFDYRDu	..GLKL+LpWFDK+TE-FpGcEYScDhGDDGSVIEpLGhPlcDN.INNGsFDVpppWlslLQPaFpppI-hs+apY.lSFDYRDt...	0	0	2	5
+1574	PF01785	Closter_coat		Closterovirus coat protein	Bashton M, Bateman A	anon	Pfam-B_1309 (release 4.2) & Pfam-B_6985 (release 8.0)	Family	This family consist of coat proteins from closteroviruses a member of the closteroviridae.  The viral coat protein encapsulates and protects the viral genome. Both the large cp1 and smaller cp2 coat protein originate from the same primary transcript [1].  Members of the closteroviridae include Sugar beet  yellow virus and Grapevine leafroll-associated virus,  closteroviruses have a positive strand ssRNA genome with no DNA  stage during replication. 	21.30	21.30	22.20	21.60	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.18	0.71	-5.25	11	1326	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	50	0	0	1130	0	171.40	35	75.75	CHANGED	hshpshs.sssspLssc-h+plhtphppplpsch.........sss--chhhtluhhLhphushSTSsKlsh..psstoh...shs.scchslpcu.lhshlpuph.htspsNsLRsauRoaEctYlshspthhpt.sptptsuK+GlPuthpYLuADFlsGosstho-c-pAshLhApcsALc+p.usts-pplssLppLG+h	......................................................t.....hh.s.s.lshs-h+.l.sp..thlspch.........shss+-ht..ha.luhhlhplsspSoShpscc.sssshoa....spt..Gh..c..hcls-chhhshlhss.hsh.s..s.psNsLRhauRop-shalshs+ps+sl.s.sttshctGlPst.aaYLsADFLsGu..slo..-.h-pu.sh...l.A+cphLc++tu..cps.lhNlpph................................................	1	0	0	0
+1575	PF00574	CLP_protease		Clp protease	Bateman A	anon	Prosite	Domain	The Clp protease has an active site catalytic triad. In E. coli Clp protease, ser-111, his-136 and asp-185 form the catalytic triad. Swiss:P48254 has lost all of these active site residues and is therefore inactive. Swiss:P42379 contains two large insertions, Swiss:P42380 contains one large insertion.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.82	0.71	-4.62	86	9058	2012-10-02 13:07:06	2003-04-07 12:59:11	18	23	5278	397	2138	7738	4927	176.10	39	75.01	CHANGED	spuE...cshD.lYuR.LL+-RIIFLustl.sDphAstllA.QLLaL-u-sssK-IhlYINSPGGsVoAGhAIYDTMpal.+scVsTlCh.GhAASMGuhLLuuGspGK..RhuLP.suRlMIHQP...hGGspG..QAoDIpIpAcElh+l+cplsclhuc+.T.GpshEcIpc......Dh-RDhaMoA..pEAh-YGLlDpVlppp	.................................................................t........hD.l.as.R.L.hc.-Rl..l.hL......s....s.......t...l..pD..p..h..A...s.......l.lA.Q.LL..a.L......-....u.p...ssp......KD.Ih.lY...I.N.S....P.......G.............G.........s.........V..........oA..............G.........h..............AI...Y....D...T...M..........p.....a....l.......+......s.............c......V..s....T....l.....s..h.....G....h....A....A..SM...G............uh...LL.s............u.GscG..K..Rhs...LP.....su........c......l......MI...H...Q...........P................h...G...G..h..pG.........QA....oD.......l....p........I..p..A.c....c.l...h.+........h+...c........p.......l.......s.....c.....l.h.uc+...T....G..p.......s.......h...E.......p.......Ipc...........................Dh...-........R.D.....p....a..h.o..A........pEAh-YG...llDplhp..p...............................................................................................................	1	751	1443	1838
+1576	PF01093	Clusterin		Clusterin	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.30	20.30	19.90	18.70	hmmbuild  --amino -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.51	0.70	-5.68	14	180	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	48	0	59	144	0	339.10	37	92.73	CHANGED	ppLpphSptGp+Yl-cElcNAlpGVKpMKolME+opEEHppLhpsLEcsKccKE-ALKhsp-sEp+LcEcpclCNETMhuLWEECKPCL+pTCh+FYo+sC+SGuGLVG+QlEEFLNpoSPFhhhhNG-clcsL..h-psppQshplsplE-sFoplsssV-pLFp-Sh.hatphp..FspshpssFh.....hpPhhhsthptthttsc.....pth..p..Ph..hp.hsh.shFQ.Fh-huhphhpuhssthpp.ht.........t.u.phs.sp.hh....sDRtlC+ElR+NSoGCL+h+-cC-KCp-IL.ul.DCotppPspspL+pElp-uLpLAEchoppYsplLp.hQp+M.NTouLL-phscQFGWVSpLANhTps.scshFploTVso+ss...sspuPuD.TpV.sVplFsSsshTlslPt-lSh-sPcFh-hVApcALQ+aKpch+pt	..................................................pLpphS.ttGpphlscElppAl.GlKphKphh-+spc-+ppLhpsLccs.+ccKp-...Alp.hp-spt+Lpc..plCptohh.s...W-EC+sCLcpsCh+aYs.sCpsu.u.VtpplEp.Fhpp.s..shhh.........hp...t-phcsL.........pp.pppst.ls..thp-tFs.phs.s.hspLFpcp..........aspt..shah.......s.....h..hp.....h..t........p.............t.hs..h..shFp.hh.ph.hph.pshs...hhpp....................s....p..h.s...p..h...t....psRhlC+ElR+NootCh+h+ppCpKCpphL.th..DC....Ps.stL+pchp-ulplsph.sppYsplLp.hQt+h.sTs.LLcphpcQFuWVSp.LAN.Tts...sp.hhpltpVh...s+...p....s..s...........s.ts.T.V.slplhsSssholplP.-.shpsspFhphVstcALppa+pp....................................................................................................	0	4	8	23
+1577	PF03026	CM1		Influenza C virus M1 protein	Griffiths-Jones SR	anon	Pfam-B_1290 (release 6.4)	Family	This family represents the matrix 1 protein of influenza C virus. The protein is the product of a spliced mRNA. Small quantities of the unspliced mRNA are found in the cell additionally encoding the M2 protein (see Pfam:PF03021).	20.20	20.20	22.60	276.40	18.30	18.20	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.48	0.70	-5.26	2	132	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	89	0	0	34	0	218.90	100	86.56	CHANGED	MAHEILIAETEAFLKNVAPETRTsIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPsDYTPDIRIGTITAWLRCKNKKSERYRSNVSESGRTALKIHEVRKASTAhNEIAGITGLGEEALSLQRQTESLAILCNHTFGSNIMRPHLEKAIKGVEGRVGE	MAHEILIAETEAFLKNVAPETRTAIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPDDYTPDIRIGTITAWLRCKNKKSERYRSNVSESGRTALKIHEVRKASTAMNEIAGITGLGEEALSLQRQTESLAILCNHTFGSNIMRPHLEKAIKGVEGRVGE	2	0	0	0
+1578	PF03021	CM2		Influenza C virus M2 protein	Griffiths-Jones SR	anon	Pfam-B_1092 (release 6.4)	Family	Influenza C virus M1 protein is encoded by a spliced mRNA.  The unspliced mRNA is also found in small quantities and can encode  the protein represented by this family.	20.90	20.90	22.80	308.20	20.00	18.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.77	0.71	-4.63	2	111	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	87	0	0	38	0	139.00	98	70.10	CHANGED	MGRMAMKWLVVhIYFSIASpPASACNLKTCLpLFNNTDAVTVHCFNENQGYMLTLASLGLGIITMLYLLVKIIIELVNGFVLGRWERWCGDIKTTIMPEIDSMEKDIALSRERLDLGEDAPDETDNSPIPFSNDGVFEI	MGRMAMKWLVVIIYFSITSQPASACNLKTCLNLFNNTDAVTVHCFNENQGYMLTLASLGLGIITMLYLLVKIIIELVNGFVLGRWERWCGDIKTTIMPEIDSMEKDIALSRERLDLGEDAPDETDNSPIPFSNDGIFEI	0	0	0	0
+1579	PF02543	CmcH_NodU		Carbamoyltransferase	Bashton M, Bateman A	anon	Pfam-B_1740 (release 5.4)	Family	This family consists of NodU from Rhizobium and CmcH from Nocardia lactamdurans.  NodU a Rhizobium nodulation protein involved in the synthesis of nodulation factors has 6-O-carbamoyltransferase-like activity [1].  CmcH is involved in cephamycin (antibiotic) biosynthesis and has 3-hydroxymethylcephem carbamoyltransferase activity [2], EC:2.1.3.7 catalysing the reaction: Carbamoyl phosphate + 3-hydroxymethylceph-3-EM-4-carboxylate <=> phosphate + 3-carbamoyloxymethylcephem.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.06	0.70	-5.33	11	743	2012-10-02 23:34:14	2003-04-07 12:59:11	10	5	526	10	274	1274	3956	344.30	32	61.74	CHANGED	sSAashSsFtpu..lslslDusGDhhsphhhluptsthth..hspFPtp.....t.......lGhha..hphsphhGashh.stGKlMuLuuYG.sssphhsslpphhchpttss........Ycthlsthpsslhcshchh....ct....h..ppcpcluAohphhlE+llhchhphhhtchs...hsp.LslAGGsuhNlphNutLhppGhFsclaV.PtssDuGsAlGAAlhshsphst......hPhchs..VY.GPshss-.......p.csssWcuphp.......hhuplAshLAsGclVuahQGRhEhGPRALGNRSILA-PpsscsKD+lNthl+.REtFRPaAPosLEEcss-hF-.spsc...PaMhhshpsREsh....................tcplPAlsHlDGoARlQ	...........................................................................................................uAahsSsFpcs....sllslD.G....h...G.....-.......h.....s........o.s.........hh...h.tc.s.s.p....h....p....h.....h...t...ph.thPpS.............................................LG.hhY.........tthTtalGF....p....h................p.......sEh....K.lM.G.LA.sYG......t...s.......t...h.....h..h..p...h...h.....pp.hh..p...h.p.s.ss........................................ah.t.....h..s.h....h....p....hh.....t....t..h..h.t....hh...................t........t......t.....ptt....hDl........A...suhQt.hh.Ec.ll...l....ch...hcth...hppts......pp..LshAGGVALN...s....sh...Ns....+...l....h....p....p......s......F.c.........c..............l..a..V...p..P...A..u...u...DuGs.AlGAAhhsht.phts......................................t.ht.p......sYL..GP.sas..sp...............tht.h.th.hts.....t.h.t.h............p.....p..tlhp.p.sAphL.Ap.u.p....lVuWaQGR..hEFGPRALGsRSILusPpssphpcplNthlK.REpFRPFAPslLtEcuscaF..c..h.s..p..su.....................Pa......MhhshpVp.tp.h..................................+scl.PAVsH.l.DGTARlQ....................................................	0	93	169	217
+1580	PF04989	CmcI		Cephalosporin hydroxylase	Bateman A	anon	COG3510	Family	Members of this family are about 220 amino acids long. The CmcI protein Swiss:O85726 is presumed to represent the cephalosporin-7--hydroxylase [1]. However this has not been experimentally verified. 	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.08	0.70	-5.01	31	285	2012-10-10 17:06:42	2003-04-07 12:59:11	7	8	264	36	73	634	456	186.70	38	79.54	CHANGED	tpasasapWhGhPIlphPpDlhshQEllacl+PDlIIEoGlA+GGShlahAuhLpll...............tsct+VluIDI-lRtpsptul-s.+sh.pRIphlpGSSscscllppl+phtpt.hcpllVlLDSsHopcHVLsELch.YusLlosGsYhlVhDTll-chsts....h.s.......psWs.GsNPhsAlppaLppps............c...FplDp...thps+hh...lTsuPsGaL+Rs	......................................h....hphpahG..hshhp.stDhh..h.QE.l.l..ac.l..+...P.cL...IIEhGstaG.G.Ss.lahAs.hLchl.................................sps.+Vls..l..DI........s...h..p..s......s........t..h..p..t......................s..R.......Ip.h.l...p......u.SS.ss..s..p.h....lpplpp.h.tp..sshl..llILDSsHop.pHVhtELph.Ytsll.os.GsYhlVEDT...s...l..s.s...hPh.....................sa..G.s.G..PhpAlcpaLtpps............p...FhlDp....hcpKhh...hohsPpGaL++......................................................................................................	0	24	52	57
+1581	PF02627	CMD		Carboxymuconolactone decarboxylase family	Mian N, Bateman A	anon	COG0599	Family	Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway [1]. In these bifunctional proteins (e.g. Swiss:O67982) CMD represents the C-terminal domain, Pfam:PF00561 represents the  N-terminal domain. 	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.77	0.72	-4.14	215	9489	2012-10-01 19:19:04	2003-04-07 12:59:11	15	45	3396	115	3044	7828	1802	82.90	18	51.31	CHANGED	Pphhphhtphttshhh...putLsh+p+cLlslusshsps.sshsh...shHhpt..Ah.psGsop...ccltcshth.tshhs....uhstth..suhthspp	...............................h.phh.thhhs.hh.....pu.....Lshpp+cLlsl.ss...u.t.ss.....s...s.shsl........phH...spt....uh...p....t...G....hop............cc..l..t.plh.th...tsh.ht.......th...stth..tuhthh...........................................	0	764	1817	2496
+1582	PF00795	CN_hydrolase	Nitrilase;	Carbon-nitrogen hydrolase	Bateman A	anon	Pfam-B_1042 (release 2.1) & Pfam-B_5155 (Release 7.5)	Family	This family contains hydrolases that break carbon-nitrogen bonds [1].  The family includes: Nitrilase EC:3.5.5.1 Swiss:Q42965, Aliphatic amidase EC:3.5.1.4 Swiss:Q01360, Biotidinase EC:3.5.1.12 Swiss:P43251, Beta-ureidopropionase EC:3.5.1.6 Swiss:Q03248.  Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.21	0.71	-4.94	58	15146	2009-09-13 06:29:50	2003-04-07 12:59:11	17	49	4520	101	4901	12501	4878	178.50	18	46.69	CHANGED	psAssQ........hs....shhshpss.htphhphl..............................tcAsct..usp.llshPE...hhlsua................ht.thtphhthuh................sh......u.thptlt...........................................................................phApppslhllsG.hspp......csst.....hYNshlhlsss.....Gphl..........s.pYRKh+........h.tah.....EpphhstG.........stsh.ssass......s.h....u+lGh..hI.........CaE..hhaPthtph.hst.............pGspllsssss	........................................................................................................................................................................................................................................................................................................thhQ........h...........hh.s....h.t...t....s....h.....tphh.p....hh....................................................ppA.spt.........ssp...lllhP.E........hh.h..s.sa..............................................................................p...h.....t...h.s..t................................................sh....................t.h.h..pt.l..p...................................................................................................................................................................................................................................................................p..h..A.....p...p....h...s.....h...h...l.l...s....G....hs.p...........................pssp..............................ha....N.sh.h..l...ls.ss..............G.plh.......................................s...pYc....K.h.HL....................h.....tah....................Ep...t.h.hs.sG....................stth....s.hpt...............................................h...................h...+....l.uh......hI...............................................CaD...........hh.a..P.p.h......h..p..t..h.s.h................tG..spllhh.t.....................................................................................................	0	1561	3031	4091
+1584	PF01110	CNTF		Ciliary neurotrophic factor	Bateman A	anon	Sarah Teichmann	Domain	\N	19.30	19.30	19.80	19.30	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.37	0.71	-5.02	2	48	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	34	4	26	265	0	175.60	49	95.14	CHANGED	MAhs-.oP.sshR+.DLCSRuIhLARKhRSDlTsLh-.YVc+QGLstsIslsusDGhPsAus-pWuE.TtspRL.-NLtAYRsF+sLLAphLE-Qp.hhssT-u-ht.AltshLLQVuAFsYplEELh.L.phthP.sEtsu.P.ssschuLFEpKLhGL+VLpELuQWsVRSl+DLR.lSpH..G.PupGuthhhsppp	....................................................MAhs-..s.ssp++.-...LCS....RSIhLARKhRSDlTsLh-sYscpQG..........L.....sp.s...l.sl..s..u....hD..GVP..sA...o..s..-..p..WSEhT-u.ERLp-NLpAYRsFcshLspl......LE-Qcsph.sPs-u-a+pAI+...sllLQVuAFAYplEELMh.L.L..ph.plP....s.Ess..uhPh...s.s...G..c..t..GLFEKKLaGL+VLpELuQWTVRSl+DLRllSpp.t.G..hsu.tst..........................	2	1	3	9
+1585	PF03450	CO_deh_flav_C		CO dehydrogenase flavoprotein C-terminal domain	Griffiths-Jones SR	anon	SCOP	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.07	0.72	-4.08	168	4331	2009-09-11 23:20:01	2003-04-07 12:59:11	12	53	1952	108	1331	3679	1203	98.20	24	19.57	CHANGED	pua...Khu+Rts.DluhVsuAhtlplp...s..........st...plpss+luhGGhuss.sh+A.ppsEphLhGpshsp.pslptAhpslt.p-hsPhsc.hcuospYRpplutsLhhRhhhps	............................................................t.ta.KhucRps...shu.lVssAht..lphc.....s.....................................s......hlp.ps.RlAhG.......GsAs.............p..sh.Rs...ppsE...pt..L...........h...........G...........p...........s....h..........s............t....p....s..........l....p...p........A.sp.........t.hh...ps..........h.........t....sh...ss.......t..u..ps...t.......Y.Rhtlstshhh+hh.t.h......................................	0	410	752	1046
+1586	PF00473	CRF		Corticotropin-releasing factor family	Finn RD	anon	Prosite	Family	\N	22.10	22.10	22.20	26.60	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.80	0.72	-3.87	7	187	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	111	8	64	192	0	39.40	47	25.30	CHANGED	tPSlSIshshclLRphL.hchscpphpphp.....sNRphLspl	....PPlSlDLTFHLLRphLEhuRAcp..tp.QAc.............pNRplh-.l...	0	11	19	37
+1587	PF02552	CO_dh		CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit	Bashton M, Bateman A	anon	COGs	Family	This family consists of Carbon monoxide dehydrogenase I/II beta subunit  EC:1.2.99.2 and acetyl-CoA synthase epsilon subunit.  Carbon monoxide beta subunit catalyses the reaction: CO + H2O + acceptor <=> CO2 + reduced  acceptor.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.87	0.71	-4.70	6	97	2012-10-03 09:55:27	2003-04-07 12:59:11	11	5	65	5	55	244	219	163.80	27	75.46	CHANGED	tphphhP......p.ssl.sscpAshhps.cssspMI++AKRPlLllGPplhpsE.hEtpsKthhc+clshltTu.....h..tsl...cchp..shh-hophlpssp.phh.hpGpaDLslFlGshhYasupsLstLKpFosplpslsIscaaHPsAchSFsNlsc--..ahchLpEhl	................................................sh.....P........tshhtschsphhps.chuuphlppAKpPhlhsGshll..h..s......h.ps.h......t.....p.......tht.h.t..plshstsu.......ht.hsh...c....cs...+Y....shhp.ps.lsssc.phh.hcsp..hDhslFlGlphaaus.sLphl+sao..sshphshhschhH.sAph..Shsshs.t-.c..hht.hltp..h....................................................................................	2	14	34	44
+1588	PF01121	CoaE	UPF0038;	Dephospho-CoA kinase	Finn RD, Bateman A	anon	Prosite	Family	This family catalyses the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form Coenzyme A EC:2.7.1.24. This enzyme uses ATP in its reaction.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.99	0.71	-4.88	13	4826	2012-10-05 12:31:08	2003-04-07 12:59:11	15	23	4560	31	1266	3845	2571	176.30	33	80.94	CHANGED	hllGLTGGIGSGKSTlushFsp.hGlsllDADllARpVVpPGssuLspIsccFG...ssllhs-..GpLcRpALtcclFucsEc+phLNullHPhIppchhcpluphps...saslhslPLLhEs.phpslsspVlVVcss.cpQlcRshpRc.ulocpcspuhlsAQhSccERluhADsVl-Npushs-	...................................h.llGLTGGIuSGKSTV....u....p....h....h........p................p....h.....G...h.sl............l...D.AD..h..l........A..........+.p..l....l....p............s.Gs...........s.hp.t...l....h....p.t..F.G..................s.p.l...l........t.......t......c..........G..........p.............L........sR.....t...t.L.up.h......lF....s....s....s....p..........p....+....p....h...L..........ssl.........l.........H......P..h....l....p.p....c....h...t........c...p.........h...............p.....p....h.......p.p.t..................sh.l..lh.-.l.....PL.L..h.E...........s.....s..........h...p..............p.....h............s.....c...c..V...l.V..Vt.s.s...c.h.............QlpRlh............pR..............c......sh..o...........c....-.cspthls......uQ.hs......hcp.+.h..th....A.....D....hVI-Nsut...p.....................................................................................................................	0	433	796	1062
+1589	PF02035	Coagulin		Coagulin	Mian N, Bateman A	anon	IPR000275	Domain	\N	25.00	25.00	25.40	341.10	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.33	0.71	-4.59	2	4	2012-10-02 16:54:34	2003-04-07 12:59:11	10	1	4	2	0	10	0	173.00	78	93.51	CHANGED	sNsPhCLC-EPslLGRp.IVopEhKDKIEcAVpAlspcstlSGRGFSIFutHPsF+ECGKYECRTVpsEcSRCYNF.PFpHF..ECPVSspsCEPsFGYTsusEhRlIVQAP+AGFRQCVWQHKCR.aGSN.CthsGRCTQQRSVVRLVTYsLEKssFhCEshRTCCGCPCRS.	TNAPlCLCDEPGlLGRpplVosEsK-KIEKAVEAVAcEuGVSGRGFSlFSHHPVFRECGKYECRTVRPEHSRCYNFPPFhHFpSECPVSTRDCEPVFGYTsAGEFRVIVQAPRAGFRQCVWQHKCR.YGSNsCGasGRCTQQRSVVRLVTYNLEKsGFLCEoFRTCCGCPCRS..	0	0	0	0
+1590	PF04733	Coatomer_E		Coatomer epsilon subunit	Mifsud W	anon	Pfam-B_3343 (release 7.5)	Family	This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.62	0.70	-5.22	7	430	2012-10-11 20:00:59	2003-04-07 12:59:11	9	22	320	7	259	625	124	243.90	29	86.34	CHANGED	tsDcLFslRN.FYlGuYQssINpup.lsshst-ss.E+DshlaRuYlAlGphtlVlsEIctus.ussLQAV+hlA.ahssstp+-thlupLpEhlucpshssNsshpLlAullah+-psas-AL+th+tu.ssLEhhALsVQIhlKhcRh-hAcppL+hMQpIDEDtTLTQLAsAWlslAsGG.pKlp-AahIFp-hu-Kas.TshlLNGpAVsshthtpa-EAEolLhEALsKDspDsETLhNLlVsshclGKs...ssR.lSQLKhsHPpHshVcchsppEspFDRhspphs	.................................................................t....Lhsl+staahGtYptsl.php...h...t.........s...s...p.t......t....hptphhhhRuhlA...t...p.....ht....ll.....tpl.....tt..ps.....s...st.......Lt.......Al....p.hh..A........p..a...h...t.....s................p....p...........ct.h......l.t....p....lp.................p...h....sp...p.........................ts.......h....h.......lhsu...l...h.h..t..ptp.p...tA...Lph..l.......p.........p.............t.......s.............s............l.....E.....h..h..A.........h.....h..l.....Q.....l...h.L...p....hsRh......Dh.A....p........+...p......l...pt...h.....p....p..h......s......-................D......s..h......Lsp.....LApuW..l....slthGu.....-p..........h.....p.pAaa.....lap.E.....h.....u.....p...p..h.....s.........s......o....................h.l.....Ls..upAsspht..schp-A...c...s...h...Lp.......p......A.....L.....p....p....c............s...p....p......s.-......s......l..h.N.h.l...lhs..h.h.GKs...ss..ch..h.s................p...L.p..t.....s.p.p....Hs....hlpc...ht.ttpt.F-phs.ph.t.........................................................................	0	98	151	219
+1591	PF04053	Coatomer_WDAD		Coatomer WD associated region 	Wood V, Finn RD	anon	Pfam-B_1269 (release 7.3);	Family	This region is composed of WD40 repeats.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.47	0.70	-5.69	60	828	2012-10-05 17:30:42	2003-04-07 12:59:11	9	37	318	6	577	840	14	397.60	33	41.01	CHANGED	psplpphshpsp.........ssphhslshKchGssphh......PpoluasP...ss+hlhV......susGcYhlYo.............ulshpspshGpuhshlWsu...pNc..aAlh-p.spslcl..KNh.cpps.hslplshss-plFs.....GsLLslpssu..lshYDhpptpllpclc.ls...s...KhVhWSss.Gp.hVAll...............o..........ccohhlls.hsh-..............................shsslpE...s.plKSutWss.s..VhlYTTts...+lpY..hlsG-sshIppl-pshYllthhs...s+lYhlD.+-hplhuhplsss.lcFppullcpch-p............................t.spll............tpplspaLpppGa.ElALphspDscpRF-LAlphGsLclAh-hAcphs....spp..........pWcpLGctALppGshplAcpsap+sp..caspLhhLYhsoGstppLp+luphApppuchsstFpsthhh.GclcpplclLhpouphs.AhhhApoau.	.......................................................................................................................................................................................................l.phshpt............tp.h...lsh.+chG..s..s...h......Ppolpa...sP......stchVlV..............sssGpY.lYo..........................uhshps.pp.h.Gpu.p.hlasu.....psc.....aAlh-p...s.p............p...........lpl...KNh..ppph.......s....l.p..s..s..h.....s.s.-.t.Iah..............G..LLhhp.s.ss...........l..shaDhpp.t.p.............h..ltclc..ls........K.VhWS..ss..up.hVulh....................s........cc.shhlhp.hph-....................................................th.psl..pE...s.pl+oGhWs.......s....s....sFlYoots...+lpY..hss.G........-hshltpL.D....p......s......hY.l....h........thhs.............s...plYhhD.+-hpshsh.s.ls.o.hca.phulhcpch-..p....................................t.spll..............tpplhpaLppp..Ga..EhALphs.p...............D....c.pRF-LALphGpLc..lAhc......hA.pphs...........spp...............................................pWcpLuchALtpsshplsc.sap+sc..saspL.hLahsoGs.t..ptLp+hs.ch.Actpsc...h.................sstF.shhhl.Gcl....cppl.clLhpss..phs.AhhhApoat.......................................................	0	228	341	487
+1592	PF02572	CobA_CobO_BtuR		ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	Bashton M, Bateman A	anon	COGs	Family	This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin adenosyltransferase, EC:2.5.1.17, involved in cobalamin (vitamin B12) biosynthesis.  These enzymes catalyse the adenosylation reaction: ATP + cob(I)alamin + H2O <=> phosphate + diphosphate + adenosylcobalamin.	23.40	23.40	23.70	26.20	23.20	22.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.93	0.71	-4.63	173	2528	2012-10-05 12:31:08	2003-04-07 12:59:11	10	9	2106	4	629	1797	875	170.90	42	88.83	CHANGED	pc+GlllVaTGsGKGKSTAAhGhshRAlG+Gh.......+VuVlQFlKG.s.hps....GEcphh.cph.......ss..........lpacthGc.GFTWc..opccp.pD..htsAppuWptAcphlt.................sspaclVlLDElshsLca......salsl-cVlssLp.sRPttpcVllTGRsA.sptLl-hADhVTEMp.lKHsFcs.Gl+AQpGlEa	........................c+GlllVaTGsG..KGKoT.AA.FGhuhRAlG....+Gh.......+VuVlQFlKG....phps......GEcshL.c.th..u......................Vca.p.s..h.Gp...GF..oWc..sps.cp...pD..............tssupps...W.pc.u..+.chLt..........................s.s..phDhVlLDElshslpa......sa..Lsl-EVlp.s.L.p.....p.R.Pt..p.....pcVllTGRss..ppl.l-hADhVoEhc..lKHsFcs..Gl+..AQtGI-a........................	0	192	403	529
+1593	PF01122	Cobalamin_bind		Eukaryotic cobalamin-binding protein	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	26.80	26.50	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.04	0.70	-5.82	11	162	2012-10-03 02:33:51	2003-04-07 12:59:11	14	7	67	16	90	185	0	281.40	30	67.51	CHANGED	hhhLssLLhhuusssthtp.CplspspppLlcsL.ppLLpshsppuu.s.NPSlhluLRLuuhpshstEphhlppLKhphppp.huSsou........p.ohGpLALhlLALpuuCcshu........cs.cLlopLccphEsEpctht.sHputPtTsYYQhSLulLALClcpscsspsVss+Lhpslp+s.hhhsuphSVDTtAMAsLALTClcpphhs.......shcsplshAlcslhEKIlppppssGhhGNlYSTsLAlQtL.sosp..sc.thsCtKshsslLsplppGsFpNPhuhuQlLPuLptKTYLDl.p.ssCsuscss..hh.....Psssosspsp	..............................................................................hhh...hh........p.C.......lst.pt.hlp.l...hh......p.....sPSlhluhpLus....s.ph...pp....h..h.ppL...........hts..s..........................t.shGpL..ALhlLALpusCcsst........hs.cLlupLpcphppttpth....sppstPhosaYphuLulLALChpstcspt.phls+Lhpshpts....tsp...hS..V.DTtAMAsLALsClppsthp........t.tpplstslcplhccIhppp.ps.pGhhG..NlaSTuLAhQ.AL.sss.....t...........sc.thsCtpshssl.Lp.p.l.p.pGtFpssh..huQlLPsL.tKoYlDl.t..pC.s.p.....h......P................................................	0	14	19	39
+1594	PF03186	CobD_Cbib		CobD/Cbib protein	Mifsud W, Bateman A	anon	Pfam-B_2468 (release 6.5)	Family	This family includes CobD proteins from a number of bacteria, in Salmonella this protein is called Cbib. Salmonella CobD is a different protein [1]. This protein is involved in cobalamin biosynthesis and is probably an enzyme responsible for the conversion of adenosylcobyric acid to adenosylcobinamide or adenosylcobinamide phosphate [1].	28.00	28.00	28.00	28.40	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.72	0.70	-5.34	139	2167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1937	0	647	1878	476	282.10	30	91.11	CHANGED	hhhlhlAllLDhllG-.Ptth......HPVshhG+llshl.-pthppt..........tp+htGhl..hhhhllsssshluh.hlhths.................hlshll.ps...hllhssluh+oLtccuttV.....tpsL.pps.sLstARctluh.l...VuRDTspLscstls+AslESlAENhsDGllAPLFahh........l.....h........GhP......G..uhsY+slNTLDSMlGY+s........c+YppFGasuARhDDllNalPARLTullhs.lsuhhh............tu........h....phhh...+Dutpa.SPNuGas.AAhAGALulpLuGsshY..G.h...cshlG..suhpsssst.cIppAlpLhttss	.........................................h..hhhhuhllDh.llG-..P..th.............HP...V.h...h..hGp.hhshl.-...phhpp..........................ttpht.G.s..l.hh.llh.l.s.sshhlsh.hlhhls.................h.t.hhs.hhhpshhlahsLuh+uLtcpsptl......................tpsL.........p.....p.......s.....Dlst........A.....R.ptluh.l...VuR.DTspL.st.stlsRAslE.olAENssDullAPLFahh..............l.u........................G.sP..............u....s..hhY+sl.....NTL........DuMl......GY.+.s...........p.+Yp.....tFG........h..suA......+.lDDlhNalP.ARLou.lhhs.lsu...h.h..............................pu...................................hchhh.....+-st.....pasSP.Nu.G.h.sE..AAhAGALulpLGGsshY..h.....G.ph....+P.hlG..ss.....p.t...s.st...cltpulpLhhh..s...................................................	0	190	410	540
+1595	PF02654	CobS		Cobalamin-5-phosphate synthase	Bashton M, Bateman A	anon	COG0368	Family	This is family of Colbalmin-5-phosphate synthases, CobS, from bacteria. The CobS enzyme catalyses the synthesis of AdoCbl-5'-p from AdoCbi-GDP  and alpha-ribazole-5'-P [1].  This enzyme is involved in the cobalamin (vitamin B12) biosynthesis pathway in particular the nucleotide loop  assembly stage in conjunction with CobC, CobU and CobT [1].	21.70	21.70	21.80	21.70	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.34	0.70	-4.78	8	2349	2009-09-13 21:11:09	2003-04-07 12:59:11	10	4	2268	0	598	1783	441	235.20	29	94.17	CHANGED	l+uhluFhTpLPlhu......DhEphpctlhtaPllGhllGslsulsthltshhhs..s.LsuhLslhlhlhhsGhhHlDGLADhuDGlhusss+cRhltsM+DhplGsuGlsslllVhLlphhuLtpls..h.hhhlhluplsAKhshlLshtht+P...ttpGhGuaFhcphcp.pplslGhllhlllslhhu...sh..h.slhAlhsulhsulhluphuc+pFGGloGDVlGAusElocssoLLuL	.........................h...slsFhT..R..l..PlPt...........ths.h.....p......p...h...s....+..u......h...h....h......a.P.l.l.Gl.ll...G.s...l...s.....u.hl..h...h.l....h.t..h...h..h.s...............s..l....u.u.l..l.s.l.h.s.h.h....llTGuhHlDGLADosDGl.h.u......s.t........s......+.............-R......h.....LcIM..+DSR....lGsa....Gsl....A...L...l.h...s...l...L.....h......+....h......h....s....l...s......p....L......s..............t.............s...........t.................h...........h...........h..............h.........h......l..........u...s...s.......s....u.....p....h....s...s......h....h...s....h...h..h..h.h.......................s+tpG.h.G.....s...h...h...h.....s.p........h.s...t.......p...p....h.......h...h....s..h....h......h...s...h....h...hs...h...h.hh........................s........h..t.s....l.h.u....h...l......s.....s.....h......l..........s...h..h....h...h....s....p....h....h.t+....cl....G.G.hTGDslGA...s...h...clsElshLls.................................................	1	189	397	511
+1596	PF02283	CobU	COBU; 	Cobinamide kinase / cobinamide phosphate guanyltransferase	Mian N, Bateman A	anon	Pfam-B_7022 (release 5.2)	Domain	This family is composed of a group of bifunctional cobalamin  biosynthesis enzymes which display cobinamide kinase and cobinamide phosphate guanyltransferase activity. The crystal structure of the enzyme reveals the molecule to be a trimer with a propeller-like shape [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.98	0.71	-4.84	192	2330	2012-10-05 12:31:08	2003-04-07 12:59:11	11	13	2134	6	530	1759	319	165.20	37	82.22	CHANGED	hLVoGGARSGKSpaAEpLs.....hphs....tps.hYlATupsh....Ds....EMppRItpH+pcR...sspWpTlEp....s..h...cLsp.sL..tp.tst......pslLlDCLTlWloNllht.p.........................p...shptphppLlssl...pp.hssslllVoNEVGhGlVPpssluRtFRDhhGplNQplAstAccVhLlluGlPl....pl	.................................................hLlhGGARSGKSpaAEplh.........................tp............tpl..hYlATuphh........Ds......EM..ttRIt.pHppp....R.........ssp...Wp...Tl...Ep......h...................cLsp.hl............pt....ttt.............tpslLlDClThaloNllht.s...............................tp..slp.tcl.pp.L...lsul......pp.....ps.u...p.l.llVoNEVGh.GlVP.tsp.lu.R.pFRDhtGclNQtlAstA-cVhlVVuGlslp..................................	1	172	358	453
+1597	PF00241	Cofilin_ADF	cofilin_ADF; 	Cofilin/tropomyosin-type actin-binding protein	Chris Ponting, Joerg Schultz, Peer Bork, Finn RD	anon	Prosite; SMART;	Domain	Severs actin filaments and binds to actin monomers.	21.10	21.10	21.20	21.10	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.70	0.71	-4.25	16	2431	2012-10-01 21:06:05	2003-04-07 12:59:11	15	42	403	61	1450	2235	7	121.70	20	53.52	CHANGED	ssspssap-l+tscp...hphllapIscs..ppplhVc......p........ss...tssssa--........Fhppls.....tp-scYulaDhchp.........suphsKlhFltWs.PDs..A.l+pKMhYAS.oKssl+ptLsu...lphplQuo..Dhs-ls.c-tltp+hp	.................................................................t.......h.pht...t.t.....hphl...lhplptp......pppl..hlp............p.............h.........ssshc.c.......................h.h.p.p.Ls............psp.s...p....Y......sl.a.c..h.ch.pt....................ssp.h.s.c.h.l.h.l.h.Ws..P.-.s...........u.....s...l.+pK...MlYAo..s+....ss...l...p.c..t...l.ps.........hph..pl.p.us......s.p-ls....p.l.t...t................................	1	449	733	1114
+1598	PF00963	Cohesin		Cohesin domain	Bateman A	anon	Sarah Teichmann	Domain	Cohesin domains interact with a complementary domain, termed the dockerin domain.  The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1].	21.40	21.40	21.50	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.32	40	1118	2012-10-01 21:34:18	2003-04-07 12:59:11	13	97	144	45	199	1131	188	151.00	25	40.86	CHANGED	lplslssssu.psGssVsVPVslssl.ss...lushshslsYDsslLphssspsGs..............llh..sssssFsss.tsssuhlshh..Fhcso.husphIspD.GlhAslsFKVpssssss.............sslshssshsasssshsplsssh.ssGslsV	..........................lplslucssA.csG..sphsV..sVolucl...Pss....Glpsh.sFslpYDs.slLpl..sslp......sGs.h................................................hh.s.ss...u........sh........a.p...s...s.....p.s..s..cG.h..lshh....aosss.tsuu.h..hl.ps-..Gl..FsTIsh....pVsusss.sGs.........................s.lp.h...................................................h................................................................................................	0	105	188	196
+1599	PF01410	COLFI		Fibrillar collagen C-terminal domain	Ponting CP, Schultz J, Bork P	anon	Pfam-B_464 (release 3.0)	Family	Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.	26.80	26.80	26.80	27.10	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.73	0.70	-4.92	36	1510	2012-10-01 23:56:02	2003-04-07 12:59:11	13	94	127	0	533	1087	7	167.00	40	15.57	CHANGED	l+sPpG.o+csPARTC+DLphsHP-....hpsGpYWIDPNpGsst.DAI+VaC..shps..GETClhPs...spl.ppsWappps....ttsWFupphpGs.................pFsYsss..........slQlsFLRLLSspApQNlTYHC+NSlAahDpts.sshc+AlhLtGuNDhElps-sssphpYpVl.pDGCpp+supauKTVlEa..cTp+spRLPIlDlAPhDlGsscQcFGl-lGPVCF	.........................................................ppP.G.opcsPARoCcD.Lphs..a..P....c....h..s....GpYW.lDPN.p.G.Cs..Du.h+VaC..Nhps....G-....T.Clh.sp......tt.h...tta...tt...............ahu........h....t..t......................hpYss.......s....hlQh.sFL+LLSspApQslTYpCpsohu.a..h..-.....t..........ts....s.s.h.c...pu.lhh.G..u........N..-..................E...h.p.h..c..........sp.h.......h.......p........s.h.....DuCp.......p...p..Gt....t.cTlh-h..pT........psppLPllDlt.....Dh.G.ts.s..p.c..aG..h-lGPVCF.................................................................	0	127	171	312
+1600	PF01024	Colicin		Colicin pore forming domain	Bateman A	anon	Bateman A	Domain	\N	23.40	23.40	23.40	29.80	21.20	23.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.98	0.71	-4.71	14	176	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	93	7	11	176	0	170.20	39	38.52	CHANGED	pcppcpsEpphlpcAs-hhsuhhcclsEphGcKacplA+-lAsshK...GKpIRSh--AhuShpKhtsN.shKhstsDR-AIsNAhculshp-hAppLsplSKuFKhsshshpstclhpchhcuhcTGNWtPLhlclEohslushAouVshhlFShslG..........sslGllGI.llsulluuhID-shlsplNphl	...............ptppptE.phlpDAlchsssFhcplsEcaGtKhpplAcElAspu+...GKpI+ss..-.....-ALpua-Ka+s.slsK...KhstpDRtAIspAL-ulphpch....upplspFuKuhthsu+shphhDlhs-hhcuhcTsNW+PlFlclEshssusuA....oslsuhh.FSlhhG...........oslGIlGh.ullhusluAhID-phl-plNchl.............	0	1	3	8
+1601	PF03857	Colicin_im		Colicin immunity protein	Finn RD	anon	DOMO:DM07441;	Family	Colicin immunity proteins are plasmid-encoded proteins necessary for protecting the cell against colicins. Colicins are toxins released by bacteria during times of stress [1].	25.00	25.00	27.20	29.20	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.73	0.71	-4.43	4	38	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	0	3	37	0	130.20	56	79.78	CHANGED	cshlLcpIhspsp.LPSITShaNPlMTclMslYsKTAPhhAllLFIhTaKpRcLIpposRptVL+SChhuslhYAshlYlhhFpNhELTTAG+sh+LhspN.ssTLhlhYhulYhhIhahoYhsLhsPlhshKhhKtRQ	....aSpVLYhLY.NKlu.LPSITSLasPlMTpLMSsYsKTAPVhGILlFLCTYKTREIIKPl....o.RKL...VlQSCF..WGPVFYA.ILI..YITLFYNLELTTAGu.FFKLlS+N.slTLFILYsoIYaoVL.TMTYAl....LLhPlLVhKhFKsRQ..............	0	0	1	2
+1602	PF01320	Colicin_Pyocin		Colicin immunity protein / pyocin immunity protein	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	20.90	20.90	21.10	21.80	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.82	0.72	-4.12	29	341	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	189	47	44	217	1	84.90	43	95.53	CHANGED	Mc.hKp..plpDYTEsEFLpFlpclhps...p..hss--....hspLlcHFpclTEHPsGoDLIaYPps...st-DSPEGllcplKcWRAuNG+PGFKp	...............hKpplpDYTEpEFlEhlpclhss..p.........ps--........hhDsLlcHFp.+.l.TpHPssSDLIaYPpp...pt--pPEsIlchlKEWRtppGhPhFKp....................	1	3	11	21
+1603	PF02674	Colicin_V		Colicin V production protein	Mian N, Bateman A	anon	COG1286	Family	Colicin V production protein is required in E. Coli for colicin V production from plasmid pColV-K30 [1]. This protein is coded for in the purF operon. 	25.80	25.80	26.00	25.80	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.05	0.71	-4.35	164	3878	2012-10-03 02:02:08	2003-04-07 12:59:11	11	7	3737	0	790	2303	1930	149.10	22	74.52	CHANGED	lDllllhllhhuslhGhhRGhlpplhulhuhlsuhhlAhhats.lushlst.......................................stthtthlua.hl...lFlhshll.stlluhhlsp.....hl.ph..ssluh.hD+lhGslhGhl+uhlllh.lllhlhshhshst.............................hhppShlhs.hlt......shss	........................................................lDhlllhllshu.slhGhhRG....hltp...........h...........luLl..uhls...........uhhlAt.t...a.h.s..l.us.h.l.st...............................................................................t.s...phht.s...sluh...hl...lFl...hs...h...ll....stllshhlsp...........ll..pt.....ssLut....hDR....l....lG.s....l....h.G....slcuh....lllh.llh.h...lh...s.h.h.s.hsp.............p.................hppShlh..hh.....s...........................................................	0	259	520	663
+1604	PF01114	Colipase		Colipase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports duplication of common fold with Colipase  C-terminal domain.	19.40	19.40	19.60	24.90	19.10	17.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.14	0.72	-4.47	9	50	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	36	7	28	47	0	39.20	63	37.13	CHANGED	PRGllINLEsGELClNSAQCKSpCCQHsosLuLARCs.KA	........PRGlIINL-sGELClNSAQCKSp.CCp+souLuLARCssKA....	0	3	3	7
+1605	PF00325	Crp	crp; 	Bacterial regulatory proteins, crp family	Finn RD	anon	Prosite	Domain	\N	20.50	14.00	20.50	14.20	20.40	13.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-7.03	0.72	-4.47	12	2310	2012-10-04 14:01:12	2003-04-07 12:59:11	15	6	1382	67	409	4399	727	31.70	52	13.95	CHANGED	Lsho..Rp-IAcaLGhThETVSRhls+LpcpuLI	..........lphT..Rp-I.GphlG.h.o.hETVuRlLpphpcpsll.............	0	79	197	303
+1606	PF02740	Colipase_C		Colipase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports duplication of common fold with Colipase  N-terminal domain.	23.70	23.70	24.60	23.80	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.38	0.72	-4.21	5	53	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	32	7	26	45	0	44.20	69	42.92	CHANGED	ENSECSPpTLYGIYYKCPCERGLTCEGDKTIVGSITNTNFGIChD	........ENSECSsc.TLYGlYYKCPCERGLTCEuDK.oIVGoITNTNaGlChD................	0	2	2	4
+1607	PF03047	ComC		COMC family	Mifsud W	anon	Pfam-B_2107 (release 6.4)	Family	This family consists exclusively of streptococcal competence stimulating peptide precursors, which are generally up to 50 amino acid residues long. In all the members of this family, the leader sequence is cleaved after two conserved glycine residues; thus the leader sequence is of the double- glycine type [2]. Competence stimulating peptides (CSP) are small (less than 25 amino acid residues) cationic peptides. The N-terminal amino acid residue is negatively charged, either glutamate or aspartate. The C-terminal end is positively charged. The third residue is also positively charged: a highly conserved arginine [2]. A few COMC proteins and their precursors (not included in this family) do not fully follow the above description. In particular: the leader sequence in the CSP precursor from Streptococcus sanguis NCTC 7863 Swiss:O33758 is not of the double-glycine type; the CSP from Streptococcus gordonii NCTC 3165 Swiss:O33645 does not have a negatively charged N-terminus residue and has a lysine instead of arginine at the third position.  Functionally, CSP act as pheromones, stimulating competence for genetic transformation in streptococci. In streptococci, the (CSP mediated) competence response requires exponential cell growth at a critical density, a relatively simple requirement when compared to the stationary-phase requirement of Haemophilus, or the late-logarithmic- phase of Bacillus [1]. All bacteria induced to competence by a particular CSP are said to belong to the same pherotype, because each CSP is recognised by a specific receptor (the signalling domain of a histidine kinase ComD). Pherotypes are not necessarily species-specific. In addition, an organism may change pherotype. There are two possible mechanisms for pherotype switching: horizontal gene transfer, and accumulation of point mutations. The biological significance of pherotypes and pherotype switching is not definitively determined. Pherotype switching occurs frequently enough in naturally competent streptococci to suggest that it may be an important contributor to genetic exchange between different bacterial species [2]. The family Antibacterial16, streptolysins from group A streptococci, has been merged into this family. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-7.19	0.72	-4.51	20	666	2012-10-02 23:56:30	2003-04-07 12:59:11	9	4	281	3	31	212	0	29.20	45	61.52	CHANGED	MKp.........ppLppFppLs-c-LppIpGGshhtphh	............Mcp........h.pL.ppFppLoscELQcIpGGthh....h......	0	6	10	15
+1608	PF02247	Como_LCP		Large coat protein	Bateman A, Mian N	anon	Pfam-B_2294 (release 5.2)	Domain	This family contains the large coat protein (LCP) [1] of the  comoviridae viral family.	27.10	27.10	27.70	33.70	26.10	27.00	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.04	0.70	-6.06	10	129	2012-10-04 01:49:40	2003-04-07 12:59:11	11	4	22	5	0	137	0	314.50	38	47.63	CHANGED	pE.sLhpLSLDDTSSl+GohLpTKlApo+llLsKsMlGGTlLpsshLsshLscushRAolsLhRTHVIpGKI+slAolNls-NTGCuLAlsaNSGlcGt.huTDIYThsSQDuhlWNPACcKss-aoFNPNPCuDuWshtFLp+T+sH..hsVpCVoGWTsoPhTDltlslsWaIssphCVP+phslusspssFslNRWMGKLoFPQGsspVl+RMPLuIGGGAGsKsAILMNMPNAhlSLaRYF+GDllFElTKMSSPYIKATloFFIAFGslo-chsN...LESFPHKLVQFuElQc+T.TlsFoQpEFLTAWSTQVhssssspuDGCPaLYAllH.DSsoSTIEG-FslGVKLlsI+sasuhGpNPGhpGoRLLGuhu	..............................h...p.uo.h.phlhpshh.lshshssGshlhsthLs..L.spts.htsh.hphhphh.uplhshhshtls.ssGhuLhhsaspG.c.ut.hso..slhphhu.pphhWNPAhp..hph.hpP.sCsDhWshpaLtpspht..hsl.slotWhssPhsDhphohshahps....p.slPc.....ph.sshp.tsshhhp+.hGpLsF.QG.ppshhph.lshGtstsstptlh.shssAhhuh.pYhpuslhh-lhhhSSPhItuThuhhlshG.sh.cphsN...h-uh...PHh.hpFuchpcps.slpFsp-.Fhshhohphhs.sshptDssshhaslhp.DusuSsl.G-hshtlthp..tshphhGhssGh.sshhhh..................................	0	0	0	0
+1609	PF02248	Como_SCP		Small coat protein	Bateman A, Mian N	anon	Pfam-B_2294 (release 5.2)	Domain	This family contains the small coat protein (SCP) [1] of the  comoviridae viral family.	21.90	21.90	23.00	21.90	19.10	18.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.93	10	94	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	21	5	0	104	0	162.30	36	20.83	CHANGED	ssps.sVYsshhhlcTPlss.osppsFuuFThDLlsusISsDuoG.NWshslhsSPIuNLL+TAAWK+GTIHhQLhhpG.AuVKRSDWuuosplsLppuhuscuhsARoWhIocP+uu-lpFslEIsGPNNGFEMhsSsWANQTTWaLEhlIsNP+QhslFElsh+lspNFEVAGNsLhPPlsLS	..................p............................................u.s.shcl.pSPhspLLpssAWh+GTL+aplVhcG.uuschusapspsQlslosspss.pohsup.pa...s...ho..pPtShELpFsh-lsGPssGFc.Mh.s.h.uspp.ahLphtlsNs+p.ssh.l.uthspDhchAGp.........t..........................................	1	0	0	0
+1610	PF01257	2Fe-2S_thioredx	complex1_24kD; Complex1_24kDa;	Thioredoxin-like [2Fe-2S] ferredoxin	Finn RD, Bateman A	anon	Prosite	Family	\N	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.58	0.71	-4.60	178	4533	2012-10-03 14:45:55	2003-04-07 12:59:11	14	41	2679	24	1588	3500	2480	131.40	29	53.12	CHANGED	lcphls+Ys....pppuAllslLphsQcp.......h..G.alstsslphlAchLs..lshhcVhpVATFY.ohFp.....hpPsG+.ahlpVCssosChlp..Gu-clhcshcccLGl..ph.G....cTT....sDGpFoLppVcCLGAC.spAPshhl....sc..........-..hapcL.Ts-plppllcphp	...........................................................h..t.htpa.........t.tushl.hLphhQpt.............G.als.tshthlAchL.t..hs..cl.tVsTFY.s.h...........hp.P.sG.....+.....ahlplC.....su......s........s........C.tl..p...G.u.pp.lh.pt...l.....c...c....c......L.s.l.........p.....s..................p.so................D....G.p....hol.p.ps.p.C.lG.sC.....s....p......u......P..s.hhl......ss......................c....has..p...l.o...s...-.pl.t.cllcph......................................	0	643	1141	1390
+1611	PF00346	Complex1_49kDa	complex1_49Kd; 	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	Finn RD	anon	Prosite	Family	\N	20.40	20.40	22.50	20.50	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.74	0.70	-5.40	7	7353	2009-09-12 08:12:15	2003-04-07 12:59:11	14	22	3508	15	1751	5117	3078	185.50	28	55.80	CHANGED	DlGAhTPhhahFcEREclh-haEtsoGhRhHsA.ahhhhGVtpDLPhGhhDclh-asc.F..tlD-h-chlTpNpIahpRlpGlGhlott-AlsaGhoGsMLRuSGltWDlRKspPY-sY-ph-a-lsh.sttGDCasRYLsRltEMRpSl+IlpQslpphPsGP...pl-th+hp.s.+schppphEslIt..hhho.saplPsG-sYstlEuPKGEhGlYLsuDso.hPaRh+lRsPuFsHLphlsth.+GhhLADlhAllGolDlVhG-VDR	..........................................................................................................................................oshh.ha.p...Rp..h.......phhEhhsG.Rhh.s.h.h.GGl..t.....D.l..............................t....................................h.t.h...h.p...h..t.t.l.t.p.h...p.hh....ts..h..tR........sluhhs.p.A.hthu..sGshhRu.o.....G.h...t.hDhR..t.....p...s.a.....hY...........t.t.........h.......h......p......l...........h......t.........tt..................sDshsRhhl+htEhhpShphlp.s...lp.......h.........t......s..................................................................................................................................................................................................................................hEss+G.....h.a..h.s.t..s.s.......h.a.Rh+hRsssa..p.h....h...h....t....luDh.hhhuo.s.hhsthD.....................................................................................	0	581	1119	1471
+1612	PF01512	Complex1_51K		Respiratory-chain NADH dehydrogenase 51 Kd subunit	Bateman A	anon	Pfam-B_780 (release 4.0)	Family	\N	20.50	20.50	20.80	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.86	0.71	-4.48	123	5590	2012-10-02 20:27:15	2003-04-07 12:59:11	12	89	3181	15	1614	4537	2950	161.60	39	31.64	CHANGED	lccuGlsGhGGA..GFPTtlKhssssc...........chlllNusECEPhlpsDctLhpcpscp..llcGhtlhtphl.uupcshIulcsphscAlpslppA......lp....ptpt.................lclthhsstYPsGsEptLlpslpG+..........tlPps....t..hP...hchGl..........lVpNVpThhslhp	....................................l+puGL+GRGG....A....GFPTGlKWphhsc.p..............................cYllsNADEsEPGshpD+tlM..cp.p..P..ap..................llEGhhIuua.Al.t.Ap.puaI..al+.uEa...p..Ahp.tLppA............ltcu..pp.shlt..........................................hthplpl+hG.s.G.tYlCGEEoALlpSLEG+.........tuhP+s..........+..PP.....ushGlh...............tPTllsNVETlssl..........................................................	0	615	1120	1387
+1613	PF00668	Condensation	DUF4;	Condensation domain	Bateman A	anon	Pfam-B_130 (release 2.1)	Family	This domain is found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non- ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (Pfam:PF00550). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.70	0.70	-5.57	42	20609	2012-10-02 12:01:53	2003-04-07 12:59:11	15	1841	2351	9	7271	22090	414	273.20	20	26.78	CHANGED	hpshhPloshQcthhahpphpssss.....uashsshlchps..sl-hpplcpAhppllp+H-uLRhhahpppt......hQhlhpptphplhhhphhs.........pph.chhhpc..hppsacLppu.PLh+stlhphtcs.pthlhhs...hHHllhDGhShsIlhc-ltphYpshp.......Lsshs............spapsau.hhpphtppt.hpcptsYWtphhpph.s......h.lstchspsstpshpst....plphslstt...htptLpphspppssolhslLlusaslhLpcasupscl.llGs.hsGRsp.....sslpphlGhFlshlPlclchp	.......................................................................................................h....hslo.h.Qp.t.h.h....h....h...t...p...h..t...........tss.....................ta.s.....h........h...h..h.....c......l.....p.................u......t..........l...........c......h.s........t....Lp....p....A..h....p....t.l.l..p..+..H..p..h..L..R..s...t.ah...tpss.....................t..h..Q....h................l....h......t.........t....h.......................h.....t.......h............h..h..s..h..t.t....................................tt.h...p.h..h.t...p.p.......ht..p...s...h..........c..l......t...........p.......s..........s..........l.......h....+....h......t...l......h............p............h...............s..............s................t.......p.............t..............h............lhls..................hHHl........lhD....G...h.S.h....t.l.lh..p.-....l....t....t..h...Y...psht....................hs.s...s......................................h.p.a...t..s...a....s......t...h..............p.....t............h............h..........p........s....................................h.......t.....p......p......h.........s.....a.....W...p....p.t.....L....t....s....h.s.s.....................................l...s.....h....s....h....s.......t....s...s....h....t...s..h...t...st...................ph..p.h.p....l.stp......httt.l..p..p...h....s....p.......p.....t.......t........s.....o.....h......t..l..l...h.u.u.h.....u......h......h.........L...............t..........c............h.............s.........s............p.............p..........-............l.....s........lG............hs.h......s....u.Rtt.......................s...s...h..p.p...h...lGh..Fhss.lsl+hp..t........................................................................................................................................................................	2	1552	3788	5729
+1614	PF00029	Connexin	connexin; 	Connexin	Sonnhammer ELL	anon	Prosite	Family	\N	20.60	20.60	20.60	20.70	19.20	19.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.33	0.72	-3.98	65	1256	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	120	6	656	1028	0	102.60	49	33.51	CHANGED	sWuhLtpLL-.pVppHSTslGKlWLoVLFIFRIllluluuEsVWuDEQScFsCNTpQPGCcNVCYDphFPISHlRaWlLQlIhVSTPo..........Llals....Hshaphc..+cc+tcp+	........................sWshLtplLp.t.Vpp...HSTslG....+.lW..LoVlFIFR..llllssAuEsVWu.....DE.QucFs.C.N.TpQPG.....Cp.NVC.YDphFPIS.HlRaWsLQlIhVSoPo..........Llahs..Hshaphpppc+....t...............................	0	61	128	329
+1615	PF03508	Connexin43		Gap junction alpha-1 protein (Cx43)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	37.00	37.00	23.60	22.80	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.38	0.72	-6.56	0.72	-4.69	3	90	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	65	1	24	85	0	20.00	92	5.88	CHANGED	RsTuSCRNYNKQASEQNWAN	..RNNSSCRNYNKQASEQNWAN	0	1	3	8
+1616	PF03509	Connexin50		Gap junction alpha-8 protein (Cx50)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	48.60	46.60	17.30	16.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.30	0.72	-3.67	4	47	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	33	0	25	40	0	66.60	70	15.69	CHANGED	IQKAKGY+LLEEEK..slSHaFPLTEVG.hEsu.Lsu.sFptFEEK...uhuPhcDhS+sYDETLPSYAQs	......IQKAKGYQLLEEEK..IVSHYFPLTEVGhVETSPLsA.PFspFEEKl...uTGPLu...DlSRuYpETLPSYAQV.	0	1	4	10
+1617	PF03601	Cons_hypoth698		Conserved hypothetical protein 698	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	24.50	24.50	24.60	25.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.00	0.70	-5.78	13	3130	2012-10-02 17:06:44	2003-04-07 12:59:11	9	5	2815	0	627	2177	1234	301.90	31	87.76	CHANGED	sGLLLshllullAhh.......Luph....hhstluAhslAIllGhlluN..ahphppphpuGltFupphLLRhGIlLhGhpLolspluslGhpullhsslslhuohllshalG.+hltLD+phuhLluuGoSICGAuAlhAspPVl+Acscc...VuhAIuslslFGTluhhlYPslhshhuhs......sctFGlahGuolH-VApVsAAGtthuspsss......sAllsKhhRlhhLuPhllhLuh..hhs+ppptutspst...+hs.....lPaFlluFlllullsohhhls........ssllshlsslsoahllhAMAAlGLssslstlt+sGhKPLlLu	.....................................................Glhl.shlluhhuhh....................lup.........h...hsh..luuhs..lAIllGhlls....s.....hh..t.........h..........p...................p..h....p.s..G....l.p....Fu....s....cpLL+huIlLhGhpL........shsp.......l......hs..lGh......t......u..l......l......h.......s.ll...s.....lh.....soh.....l......l.....sh.a......lu.+....hh....tl..D..c.c..h.uhLlu..sGouICGuu..AlhAsuPll...+...A...c...s...cc...........suhA.lus...lslaGoluhhlaPhl......h.s..h..h.shs........spsaGlasGsol.H-....lup.VlAAutsh...u...s..put.s...................hA.s....lsKl.h.RVh..h.....L...sP..lsl.ll.uh..........hh.p.....p...p..pp....t..s.psptt..................+hs.........................lPaFllh.Fl...ls..ul.l.so..hh.....h...ls............................ps....lh.s..h...l.....t.....p........l...s.phhlshAMuAlGLssplpsl.t.c..s..G.sKsllh................................................	0	209	414	530
+1618	PF03602	Cons_hypoth95		Conserved hypothetical protein 95	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.12	0.71	-4.89	27	4548	2012-10-10 17:06:42	2003-04-07 12:59:11	10	7	4379	14	1006	14823	4683	175.00	31	90.57	CHANGED	hRIluGph+G.......RpLts.su.pshRPTsD+VREulFNhltsh......lststhLDLFAGSGuLGlEAlSRGAppslhlEpstcuht.hlccNlptLth........thlhpssthth.phstps..FDlVFlDPPYtps....ppslphlsppshLp.....suhlhhEptpc.ttl.p.ssshphh+c+thGpsplphat	.............................................................hRIIuG.p.a+GRp.L....s......s....p..u....t..s...h...RP..T.o.D+..V.+.E.slF.N...h.Lssh................hp.s.u.p.s.L..D..L..FA...G.S..G....u..L..G...l......E...A...l.....S.....R.....G...A....s.......p.....s...........s.....h......l..Epst..pu..hp.....hlp....c..N......l....p....t....l.c.hps.......................hpll.p....t...s......s.....t............p.........s.........l............h......t......h......................................t.......s.................t.....t........F...D......ll...F.l..D...P.....P........Y...pp.......s........h.......h..............p.p........s.......l.p........h........l...t....p........p........s........h.L.s.......................ps..u..l..l.h..s..E.p..s...p..p..........t...h...s.......p............s....s....s....h....p....h.h.+.c.+thGpsthphh...................................................................................	0	343	672	859
+1619	PF04234	CopC		CopC domain	Kerrison ND, Finn RD, Bateman A	anon	COG2372	Domain	CopC is a bacterial blue copper protein that binds 1 atom of copper per  protein molecule.  Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm [1].	22.60	22.60	22.60	22.90	22.50	22.50	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.20	0.72	-3.36	162	1651	2012-10-03 16:25:20	2003-04-07 12:59:11	7	10	1283	12	405	1175	336	96.80	35	42.58	CHANGED	HupLhuosPAssuslssuPsplpLsFsEslp.......thuslpls.sssG.pshsssp.......spsss........pshslslss..Lss....GsYpVpW+slS.sDGHshpGsasF.sVp	..................HApLppssPAss.up..l..s..sA.PptlsLsF.....oEslp.s....................sFou..spls......ssps....c..s..lpsts..........................s.phst.....tstpplhlsLsps....Lts................Gs.YsVsW+lVS.s.DGH.spGpaoFoV....................................	0	101	242	333
+1620	PF00127	Copper-bind	copper-bind; 	Copper binding proteins, plastocyanin/azurin family	Sonnhammer ELL	anon	Prosite	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.54	0.72	-3.77	31	1467	2012-10-02 17:41:00	2003-04-07 12:59:11	15	49	912	431	532	1917	1988	103.80	25	50.66	CHANGED	spstlsscsus.hsFsssslslssG-plhalN.........sshsHNlVhsc.........DtlsuGs-sstlphsc.....cshl.usGEshSVThs...tsGs..YsaaCo.P.HtuhhMhGpVsVp	........................................................................................h.....thttss..htFp.P...s....t...lplps.G..s..s..l..p..a..h..s..................ss.hs..H...Nhshsp......................................sth..s...t.s.h.pt....hh.p..t.....................................t.h.......t......s...G..c..s....h..s..l..T..Fs.....psGs...Ypa.....h.....Cs..P....Hh...s.h....s.MhGplhV...................................	0	126	321	455
+1621	PF00649	Copper-fist		Copper fist DNA binding domain	Bateman A	anon	Prosite	Domain	\N	25.00	25.00	39.10	37.80	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.38	0.72	-4.76	23	240	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	128	1	176	247	0	39.50	57	8.31	CHANGED	M.llIsGpKaACtsCIRGHR...uSoCpHs.-R.Lh....cl+pKGRPs	................M.lIsGtKaAC...EsCIRGHR...sSsCpHs.D...RsLh....pl++KGRPs......	0	46	97	155
+1622	PF01218	Coprogen_oxidas		Coproporphyrinogen III oxidase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.00	20.00	22.60	22.50	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.90	0.70	-5.86	93	2155	2009-09-11 07:50:01	2003-04-07 12:59:11	13	8	1940	24	700	1719	2513	276.40	51	93.10	CHANGED	pplcsalhsLQccIspuLE....th.D...G.....ts..pFttDsWpR...t..pG.....GGGto+VLpsGpVFEKuGVNFSpVhGsthPsuAost..Rs-l.....uGt................sFpAhGVSLVlHP+NPalPTsHhNlRaF..lu...ptp...spsssWWFGGGhDLTPaYs.....a-EDshHaHpss+sACssa.GsshYP+aKcWCD-YFaLKHRsEsRGlGGlFFDDLs...p....hs...F-psFuFhpulGcuFLsAYlPIVc+R+stsau-cERpFQlaRRGRYVEFNLVaDRGThFGLQoG.GRsESILMSLPPhscWcYs.apPpsGS.EAcLhc.alts+-Wl	.........................p.tscpalhpLQDpICptLptl..D.......G........................upFhcDsWpR...p.s.G.................G.GG.po.....RV.........lp.............s..............G..............s...............VFEpuGVNaSpV.aGp.hhPs.uAsst...R.sch...........uGt..................................sF.AhGlSLVlHP+NPalPTsHhNsRaF....hs.................p...t....................st.ss........sWWFGGGhDLTPa.Ys.....a-....E.....D...shHaHpst+s.......hC.p..........s.a.......u....t....s.............h....YP+..a...KcWCD-YFaL+HR.s...EtRGlGGlFFDDL....s...s.............................s.....a-.p.sF.uF.hpuVGcuahsAYlPIVc+R..+..s..h.....sasEcERpaQLhRRGRYVEFNLVaDRGTlFGLQ.....TG..GRsESILMShPP.hs..+Wc..Ys.............a...........p...P..pss........S.EutL.p.hh...s+-Wl...........................................	1	214	409	570
+1623	PF03232	COQ7		Ubiquinone biosynthesis protein COQ7	Bateman A	anon	Pfam-B_3545 (release 6.5)	Family	Members of this family contain two repeats of about 90 amino acids, that contains two conserved motifs. One of these DXEXXH may be part of an enzyme active site.	22.00	22.00	22.00	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.23	0.71	-4.79	47	840	2012-10-01 21:25:29	2003-04-07 12:59:11	8	7	777	0	370	769	1628	164.50	33	78.42	CHANGED	thl-chIRVDpAGEhGAspIYtGQhtVLu....csphushlpcMh-QEptHhppFscLltc++VRPTlLtPlWcluGFuLGuuTALlGccAAMACTsAVEssIscHYssQlcpLt......ps-tc......................LtspIpcFRD-ElEH+Dhulpp.sAcpAssY.lLopsI+hGCRsAIhluc+l	.........................................t..httlhRVsHsGElsAptl....YpGQh..h.........shp..........pspl+thhp.chhcpEtcHLshhpchlp.ch..ps..R.P.olLsPlWh.s.uuau..l...G.......ss.su.lhGccsuhuhssusEcplspHhsspLcpLs............tp-tc..........................psllcphRpDEhcHt.cpA.......lct.u.u..t..p..h................h.th....t.......................................................	0	111	206	296
+1624	PF04803	Cor1		Cor1/Xlr/Xmr conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6320 (release 7.5)	Family	Cor1 is a component of the chromosome core in the meiotic prophase chromosomes [1].  Xlr is a lymphoid cell specific protein [2]. Xlm is abundantly transcribed in testis in a tissue-specific and developmentally regulated manner.\	     The protein is located in the nuclei of spermatocytes, early in the prophase of the first meiotic division, and later becomes concentrated in the XY nuclear subregion where it is in particular associated with the axes of sex chromosomes [3].	22.10	22.10	22.40	23.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.66	0.71	-4.39	12	157	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	50	0	76	193	0	115.40	34	52.16	CHANGED	sKsLpsKRKRlEshoKsShKuSppKlEplW+TQpspRQKLsp-aSQQhhslhQQW-hDspKhcEQcEKLsNhF+QQQKlhQQuRlVQsQ+lKsl+pLaEQFlKshE-lEKs+-shhpusQpEL+KEMAhL	.......................sL.tK+++hph.spsohps.pp+l...cphh+spp.ppRQKlspcaSpphhslhppa-hDhQKhcE...p...c....EK....ls..s..happQQK..hhQQschlQpQ+Lcsh+plh-palKshpslEpsppphh.shpsEhcc.hs..............................	0	12	14	22
+1625	PF01544	CorA		CorA-like Mg2+ transporter protein	Bateman A	anon	Pfam-B_944 (release 4.0) & Pfam-B_3206 (release 7.5)	Family	The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli.  CorA is virtually ubiquitous in the Bacteria and Archaea.  There are also eukaryotic relatives of this protein. The family includes the MRS2 protein Swiss:Q01926 from yeast that is thought to be an RNA splicing protein [3].  However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.91	0.70	-5.38	79	8370	2009-01-15 18:05:59	2003-04-07 12:59:11	13	47	4035	34	2466	5606	407	264.00	18	74.31	CHANGED	tpshhWlclptsspp..phphLtpt.......hslst.h.hp........hhstppps+h-.......hpsshhlhlpshphspsspt...h.......lshhl.ssshllTlppps...hphh.......pplhppht........ttht.pssttllhtllptlscphhphlcplppclcplEcpl............pppspphhpclht..l+...+p.lspl....+chlhsppphl........phhp......pttthhsppp......lpclhsclpp....lhpthphhp-hlptlt-thtshlspp.......hNchh+hL...Tlloslh.lPhTl..lsGhaGMNht......hP......thphta......hhhhhlhlhhlhshlhhhhh......++	...............................................................................................................................................................t....hWlpl.t.sptp...pht....ltpt.......ht.l...h..hpt...........hh.p....p.p.ps..+hp..................t.s.h......hh.l..h....h...t...h...h..p.t.ppp..................................l.thhl....t........p.....p........hllo...hp...pp.......hh...............................pthhpph...........................tthh.hss....t..h.lht.l.h.......p.ths......cth....hth.l.cp.lppp...h..p.pl-.ppl.............................ttptp...p..p........h........t..plhp.....lc.........cp....lhhh........................................ppslt.....s.......p.p.hl..................................phhp.................t..h....h...hs..p.p.p.....t..th...........hc.-.l.hp.chpp...................hhph.hch...h..t...ph...ls...t...h...h.......p.......sh...h...u...h...l....stp.............................N.p.......h.......h...c.......h...l..............olh.......oslh...lP....Th...ls..u...h..aGM.N..hp................hP................thp.h.ta..........hh.h.h.s........lh.hh.l.hhsh...hhhh.hh.++...........................................	0	668	1466	2076
+1626	PF03311	Cornichon		Cornichon protein	Mifsud W	anon	Pfam-B_3813 (release 6.5)	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.70	0.71	-4.00	31	647	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	286	0	397	527	2	110.50	35	84.83	CHANGED	Mu.phh.h.alhulllssshlFhtlaalIhhuDLEsDYlNPI-hCs+LN.hVlPEhhlHuhLslLFLlsGaWhsFL........LNlPllsYNshphhp+.....spl..lDsT.EIF+p..Lstcp+cshlKLuFYLlhFFhYLYp	...............................h.h.ahhullhsss...lhh.laal.....Ih..hs-LcsDYhN.Ph-.Cs......p..........LN.................hllPEhh..l..Huhhsl.ha..L...hstpWhhhh........LN.l.Pl.lhaphh+.hhpp.......tl..hDsTpIhpt.......Lshpp+-uhhKLuFaLl.FFhYLY.....................................	2	101	172	283
+1627	PF04694	Corona_3		Coronavirus ORF3 protein	Mifsud W	anon	Pfam-B_5763 (release 7.5)	Family	\N	23.60	23.60	25.00	54.80	23.20	23.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.21	0.72	-4.09	4	89	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	40	0	0	78	0	59.00	82	84.35	CHANGED	MDIVKSIshSVDAVLDELDsAYFAVTLKVEFpoG+hLVCIsFGDTh.tA..phhu.Lthc	MDhVKSIshSVDAVLDELDshhFAVTLKV.FpoGKLLVCIGFGDTh.EAcpKAYAKLtL.......	0	0	0	0
+1628	PF03262	Corona_6B_7B		Coronavirus 6B/7B protein	Mifsud W	anon	Pfam-B_4476 (release 6.5)	Family	\N	25.00	25.00	208.10	119.30	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.46	0.70	-5.08	5	357	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	39	0	0	270	0	194.70	87	100.00	CHANGED	M.IVllLVClhLuNuhGIKtssQEcDL...HEHPThTWELL-+FVGNTLYITTsQILSLPLGAcV+C-sVEGFsCoWPGFcssAHDHIDFYFDLSNPFYSFVDoFYIul...G-tspKIsLRlVGATPK-KRLNlGCHTSFu.VcLPFGTQIYHD+DMphhV-GRHLECTHRVYFVKYC.PaasHGYCFcDKLKVYDL+Rl+SpKsF-KlNQac+oEL	....................KATTVQsDL...HEHPVLTWELLQHFVGHTLYITTHQlLALPLGSRVECESVEGFNCTWPGFQNPAHDHIDFaFDLSNPFYSFVDNFYI.l...GEGNQRINLRLVGAVPKQKRLNVGCHTSFA.VDLPFGTQIYHDRDFQHPVNGRHLECTHRVYFVKYC.PYNLHGYCFNEKLKVYNLsQLRSKKVFDKINQHHKTEL..........	0	0	0	0
+1629	PF02398	Corona_7		Coronavirus protein 7	Mian N, Bateman A	anon	Pfam-B_1574 (release 5.4)	Family	This is a family of proteins from coronavirus which may function in  viral assembly. 	22.30	22.30	23.10	47.60	19.00	22.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.39	0.72	-3.53	2	105	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	47	0	0	81	0	77.30	75	100.47	CHANGED	MLVhhpAVhlTVLhLLLIGRlQLLERLLLsH.hNLpTVs.......................DFNILa+sLAETRLLhVlLRlIFLVLLGFsCYpLLshLh	..MLVFLHAVhlTVLILLLIGRlQLLERLLLsH.LNLpTVsNVLGVsDssL+VphhQLLKPDCLDFNILa+sLAETRLLhVVLRVIFLVLLGFsCYpLLssLh......	0	0	0	0
+1630	PF03187	Corona_I		Corona nucleocapsid I protein	Mifsud W	anon	Pfam-B_2926 (release 6.5)	Family	\N	25.00	25.00	75.50	75.20	24.60	16.30	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.43	0.70	-5.17	3	82	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	48	0	0	55	0	183.00	55	98.69	CHANGED	MESSRRPLGLTKPSADcIhKIEAEGISPSRLQLL.NPIPGVWFPITLGFLALPNSRRERSLSLQhDKECLLPMESQLLSKRDIGIDTTDVLLKHLMASRSNYCPDGIFTILEQuPMLcsSMATsLTESSGSQlsRhhspPLLTLLKGTQVAMRLFLLGLRPVRYCLRVoMLKAQEGLHLLVDLVRGH..NPVGQIIALEAlPTSASLPLL	....tS.pt.l...p.o..ph.h.tsEp.NPspLhLL.NHpEshh..hI.GSLtL.sFK+.coLNhQhsK.h.LhpES.LLKpRDIGhDTTsVLLKQLMus+SsCspDGIFTIhtQs+MPtpsMssshptSSGSLlT+Lh.lPh.hFppGhQlsMRLFhLGhR.sRasL+shhLKAQEGLhLlsDLl+uH..pPlsQ.hshEsh.s.ts.PLl........	0	0	0	0
+1631	PF01635	Corona_M		Coronavirus M matrix/glycoprotein	Bashton M, Bateman A	anon	Pfam-B_845 (release 4.1)	Family	This family consists of various coronavirus matrix proteins which are transmembrane glycoproteins. The M protein or E1 glycoprotein is The coronavirus M protein is implicated in virus assembly [1]. The E1 viral membrane protein is required for formation of the viral  envelope and is transported via the Golgi complex [2].	19.10	19.10	19.30	19.30	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.48	0.70	-5.39	14	976	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	276	4	0	775	0	199.50	48	97.13	CHANGED	h.SN...solshp-llphl+sWNFshsl.ILlhlhllLQaGYss+S+hlYllKMhlLWLLWPLslAlolFsAl..aslN.hshhuhSIlhAslohlhWlhYFlsSlRLapRTcSaWSFNPEoNsllslsl.hGpphshPlhpsssulThsllsGpLhh-Ghclup.sssssLPphlTVApPsshhhYch.u+..s.shsssoGaAhYl+hKt.Gsaptssshpsshs-sppLhp	........................sh...tphh.....hhtpaNh.hsh.hh.hh..hhhlLQaGhsphShhlYhlKMllhWlhWPlslAlslhssh...Ytls.h.VhhuhSIhhAllsh.hhWlhYFVpSIpLa+RT+SWWSFNPETNAlLslsh.hGpphshPl-usPpslThTllsGsLYsEGhKlAsGhsl-cLPKaVhVApPoRphlYph.VGK..p.puussoGaAhY...V+uKt.G.sYs.spshpsshopttpLh....................	1	0	0	0
+1632	PF04753	Corona_NS2		Coronavirus non-structural protein NS2	Mifsud W	anon	Pfam-B_3747 (release 7.5)	Family	\N	25.00	25.00	26.60	179.60	24.00	17.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.68	0.72	-4.11	3	81	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	63	0	0	43	0	108.40	73	99.55	CHANGED	MEIWRPShKYLRhTR-FGVT-LEDhCFKFNYCQP+VGYCRVPL+AWCRNQGKFAApFTL+S+-KSa+ppFGVITSFTAYGNTVcEAVSKLVEpAuDFIsWRAppLN+YG	..MDIW+PEhKYLRYTNGFNVSELEDsCFKFNYpFPKVGYCRVPs+AWCRNQGpFCAThTLYGKSK+.YDKYFGlITGFTAFuNTVEEAVNKLVFLAVDFITWRpQpLNVYG.	0	0	0	0
+1633	PF05213	Corona_NS2A		Coronavirus NS2A protein	Moxon SJ, Bateman A	anon	Pfam-B_6568 (release 7.7)	Family	This family contains a number of corona virus non-structural proteins of unknown function. The family also includes a polymerase protein fragment from Berne virus and does not seem to be related to the Pfam:PF04753 Coronavirus NS2 family. This family is part of the 2H phosphoesterase superfamily [1].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.74	0.70	-5.06	4	104	2012-10-03 21:31:47	2003-04-07 12:59:11	7	4	66	0	0	95	1	202.80	52	38.20	CHANGED	AYADcPsHFlshPlsp.psFltsahcLQ.....EGhssKhQsAPHISLTMLclpsEDhcpVE....-IlD-Mshspu..lshsNPHMhG+phVhDVcGl-pLHD-lVslLRc+GhssDQoRhWhPHhTIuplpDsuh.sKh.......hpFshpppl..........tch-hVKLGAsKtsuhYEhIso...........sWsupR.LCapsss.p.Sc.htYhsLss...EhptG.l..Ncsss...hShcYpsppahh++V+DpSpa..hRTu	............................AaADKPNHFINFPLspFpGFhhpYhtLQ.Qll-..G..lDCK....lQpAPHlSls...hL.D..Ip..s-pY+sV-....hAIQEllDDhthh..EG..pIpF-NPHh.L.G.R......ClVL.......D.V.+G.VEELH-...DlVNhlRc+GCsADQSRpWIsHCTlAQhs-tslpIKt.........hQF.a.Kh.sh.....N..osAclElVKlGupKh.DGFYpo.hS...........hWhG.R.hpYpPPTsKhu.IhGYCCl-hlRt-LE.GDLP.sD--AWhcLSYHYppNoaFFRaVacpS.Y..FRp..............................................	0	0	0	0
+1634	PF03053	Corona_NS3b		ORF3b coronavirus protein	Mifsud W	anon	Pfam-B_2130 (release 6.4)	Family	Members of this family are non-structural proteins, approximately 250 amino acid residues long. They are found in transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) isolates. These proteins are found on the same mRNA as another product, designated ORF3a. While ORF3a/b has been implicated in TGEV and PRCV pathogenesis, its precise role remains unclear (see [2,3]).	25.00	25.00	25.60	25.30	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.42	0.70	-4.81	4	228	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	53	0	0	204	0	211.70	53	99.20	CHANGED	MhLGLFphTls.......osVpposppsplSt-sshtlppsVVshRpssplsuFhlsSlFVhFFALFKAoSa+pshhllhh+lLslhlYsPlLhasGAYlDAhllsssLhuRhhalsaasWhYKsacFIlaNoTTLhFlpG+Asaacs+u....aVhL.GGspYlhlGsphVsFVSs.sLYlAIRGpt-uDLpLlRsVELLsGchlYlFSpc.lVGlsNuuFpp..L..........DchhsIS	...MIGGLFLsTLu.......hI.V.s.s.p.sh.l.s.Nhsp.s..slVQQ+pVV.Sup..hpShahEFSIAlLFVhFLALYRSTNFKsCVulLMFKIlSMTLlGPMLIsaGYYIDGIVTT.TVLuLRFlYL.uYFWYlNSRFEFILYNTTTLMFVHsRAAPFhRSSHuSIYVTLYGGINYMaVNDLTLHFV.ssh.l......hlAIRGhscADLpllRsVELLN.....GchIYlFSQEsVVGlhNAAFsph.l..........sc........................	0	0	0	0
+1635	PF03905	Corona_NS4	Coronavirus_NS4; 	Coronavirus non-structural protein NS4	Finn RD	anon	DOMO:DM04795;	Family	\N	25.00	25.00	42.70	42.70	18.80	16.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.22	0.72	-4.16	3	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	45	0	0	37	0	47.40	70	65.50	CHANGED	MPMATTIDsTDYTNIMPoTVSTTVYLGuSIGIDTSTTGFssFSa.............Y	MPMATTI-GsDYTNIMPhTVhTTVYLGsSIGIDTSTTG.pshsh.......................	0	0	0	0
+1636	PF00937	Corona_nucleoca		Coronavirus nucleocapsid protein	Bateman A	anon	Pfam-B_267 (release 3.0)	Family	\N	24.60	24.60	29.90	25.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.18	0.70	-5.50	21	1034	2009-09-11 06:29:42	2003-04-07 12:59:11	13	4	296	36	0	939	0	294.10	37	87.79	CHANGED	Mu........................plsatsp...stppsppttt......hPh.......................SaFssLptpscpthh.hhsGsGVPhutG.stspphGYWpRQpR..a+.scGppppLss+WaFYYhGTGPaA-hcatc.......cp-GVhWVApcGAcssssu.lGoRsssp...pslss+Fssu..lPpshhlps......pspSRssSRus......SR...upS..RusSts..........uRssS...psRpsss...............lhsslhttLtslshsppp.........................tsppssploppsst-stp....K.caKRossKu..psVspsFGtRussp...NFGsschlctGscsspaPtlAELlPosuAhhFuSclssccps..Dsl.........plsashshpls+csPshppah....pplsAY...........scPpcp.cK.pppp	...............................................................thsh.......................SaFpslp.pphst...hhtspuVP.s.s.ptspQhGYWpRpsR..a+.scGtpK.lsstWYFYYhGTGPtAchpats........p.-GlhWVAtcGApspsps...GsRsssp...-thsh+Fssu..hPps.hh.s..........pGcSttsot..us......S..t....upS....Rs.sS...............RpsSpsRpssu........................................t.sl.hsthtplh.spp.p..............................ps.pphs.p..tpss.-h.p......+.hhKRT.s.t...pVspsFG.Rs.sp......NFGDsch.ppGhpstphsthhphsPostAhhFGSpls.c.ts.sth...........plpaphshhlscscsphpphl....pplsuh................tcPpp.t.t....t...............................................	0	0	0	0
+1637	PF01600	Corona_S1		Coronavirus S1 glycoprotein	Bateman A	anon	Bateman A	Family	The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 and S2 Pfam:PF01601 [1].	25.30	25.30	25.40	26.50	23.40	25.20	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.94	0.70	-6.20	8	2634	2009-09-11 07:53:46	2003-04-07 12:59:11	11	4	115	4	0	2424	0	374.30	50	73.17	CHANGED	hhG.us.VahhpSuh+.PcGaphpshhhhssssos.susssSsQ....sClhul.taupsssssShshTAss..sGhShsss....cFshs.......csNhsctslFlTasapo.hshuCs.ouh......l.puah+IshhKsts...salFYNlTls.......luphPphhp..slsphsSVYlNGahhFTostscsVshusspacoGG.....hThtlhphVcALs.hsNsohpcVIhCD.SPhuhLtCQ.sTuNhsDGFYPhoso....phhlVhppsSVsTh.shpsaTFsNlosu.........PssGGlpohslYtopsspouhhNFNhohlouFsh+sSpFhhhsa......h.pspFpspshNsGhWhNSlslu..hs.hslQussc.ssFu...TsCauhShsGsusshuVausphsp.apshhhlYVoho-GShIpTuspsPlhshpsasNlTLDcCs-YNIYGRsGpGhITNsTsohlut.........Ih.TSsShDlhshpsshusshYpVsPC-ss.pQhVVssGclVGllTShNpTu............p.htN.aYlplhNhT+hhpR	...............................................ts.VahhQSuhR.spGWHlpGGAYAVVNsos.ssNAG....o....up.............p...CT....s..Gs........I.......p.....s..h.......s........s.......Au....Sl...A..MTAP...........pGMuWSps..................QFCoA.........HC..NF.o...-...h....o...VFVTHCaps...suCPlTGh.......l.psaIR.ISAM.+..s..........upL....F..Y..NLTVo..............VuKYPpFKShQCVNNhTSVYLNGDL..V.FTSN.p.TpDVsuAGV.a.aKu..G..G....PlsY.plM+phcsLsaFsNGospcVlhCD..oPhshLt.Cp......shshsDGFYshss.......hhhs.h..pShsTh...hpsaoF.N.osu.........ss...u...s.h.p..s.h...hhts..t.hps...sh.h.sFs.s.h..s..Fsh...ptsp.ahh..................s.F...h....ps..s......Ghh...sslsst.....s..h.shpt.hsp..sFp......phC....h.......uhs......ss......hphsl..hth...t..........phh.lahphptGp.h.ots........h...h..h.hs.CstYslYsh.G.GhIh..s....p...sh.........lh.so.uhphhhhps.....hapl.PCt...tQhsh.ttthhs........................................................................	0	0	0	0
+1638	PF01601	Corona_S2		Coronavirus S2 glycoprotein	Bateman A	anon	Bateman A	Family	The coronavirus spike glycoprotein forms the characteristic 'corona' after which the group is named. The Spike glycoprotein is translated as a large polypeptide that is subsequently cleaved to S1 Pfam:PF01600 and S2 [1].	30.00	30.00	30.20	30.10	29.90	29.00	hmmbuild  -o /dev/null HMM SEED	610	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.17	0.70	-6.42	22	1416	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	312	44	0	1305	0	413.10	39	54.14	CHANGED	sCs.Ph.....lsYushulppsGulht.lshp.......s.stlsslhs.....tslpIPoNFTlolpsEYlQhpsp.lolDCupYVCssss+CppLLpQYuohCpsIpsuLptsupl-shplhshhoss..puhpls....shpsFsus..................aNhosl...Lsss..........up.t.RSsIEDLLFsKVhouGlGtVDttYccCos...G..tsltDLlCAQhYNGIhVLPsllssphhuhYTuSLlGuhshG....Gl.TuAAuIPFuhslQuRLNalulppsVLpcNQKllAsuFNpAlusIpp..............GhsosupALsKlQ-VVNppupALspLssQLssNFtAISSSIp-IYsRLDtlpA-AQVDRLITGRLsALNuaVoQpLschsclcsSRpLAtpKlNECVKSQSpRhGFCG.sGsHlhSlsQsAPpGlhFlHhshlPopatsVpAssGlClss.....hhhhhsPthulFh......psso..........ahlTsRshapPchhotu-hVplpoCsVsasslsps.lsshl.P-..hhDhscpLscahpsh..spshPshs..hshaNhTh..LNLosEI..............pcLpplIcsLNsohlDLc.LsphEpYlKWPWYVWLsIshullhhlhlLlahhhsTGCCG.hhuChu.....spCtppCp...thpp...h..hcphHsp	.......................................................................................................h.lP.thshs...Ehh.h....h.lss..alss....C...h.pYh.hC.pl.t.l...s...s.....hh.........................................................................................................................................thYTsuhhuuhshu....uh.ouAsul.PFuhplQhRlNhlulppslL.cNQchlAsuFNpAluphp...............uhpohs.ALtplQsVVNpputhLsphhtpLppNFtAISSslt-IhppL-tlpApsQlDRLIsGRLsuLsshsotp..phhclptptpLAhpKlsECV+SQS.RhsFCG.pG.HlhohspsAP.GhhhhHhsh.P.t..ph.s.suhChts................hh...t.shh.........t......................ahho.p.ha.Pp..p.tshl.htsCtssahphs.s.h...h..p....shpcplpchhpph..p..hs-...hs......hN.Th..LslptEI..............pclpthhpslNpohlsLp.lshhc.........................hhhh.Tsps..........ssh........ht.......................................	0	0	0	0
+1639	PF00115	COX1		Cytochrome C and Quinol oxidase polypeptide I	Finn RD	anon	Pfam-B_23 (release 1.0) and Prosite	Family	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.90	0.70	-5.86	94	254351	2009-09-13 13:30:05	2003-04-07 12:59:11	15	23	108179	109	2006	206187	5121	227.90	58	95.26	CHANGED	pcp.luhhYllhuhhhhllGslhullhRhpL..shP...................sh...lssp....saNplhohHushMlahhshshhhG.hu.allPhhluscplshP+Ls.shuaWlhshusllshhuh......hhths...............stsWh.Ys.Phs....................s..hhhhulhlstluullsulNhlsT..lhphRs.uhsh..h.slh.sWuhhssullhlhuh.Pslshs.hhh.h...h...hh..stsussllapalFWaauHPtVYllllP.uhGllu.llsphs.t+.lauaphhhhuhh.uluhlu.hhlauHHhas.sGhshhhpshhsstohhlu..........lPsult...........lasalsT......hhtu....p....hphs.sshhasluhlhhF.hhGGloGlhhuhsslshhhHsTaalVAHaHhslhGuhshshhuulaa....hhPphtGp.....hhsppluphpFalhhlGhslhFhshph.hGlh.GhsRRh....hsa......sst.......htsa.....hlpolG..uhlh	........................................................................................................h.lG.suh.ShlIRhEL....upP...........................suh....lssDQ........lY.Nsl.VT.A.HAFl.MIF.FM.VM....P.l..MIGGFGNWLl...PL..M.lG...A..P............DM....A....F..P...R....M.N....NM.SF.W..LLP.PS.lhL.Lls.So.....h.V.....EsGs.......................................GTGW.T....V.YP...PLu.usluHs............GuSVDLuI.FSLH..LA.GlS.SI.L.G.AI..NFI.T.T.........l..I...........N......M........+..............s..........s...h..o....h...c........p......h.......PL.......F....V..........W.........u........V.........h.IT.Al.L.L.....L.L.SL..P..V..LA.G....A.I..TM.LL.T.D..RN......l.NToFFD...............PuGGGDPl.La.phh...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	538	1218	1661
+1640	PF05051	COX17		Cytochrome C oxidase copper chaperone (COX17)	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_5838 (release 7.7)	Family	Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast [1]. The structure of Cox17 [2] shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.	21.80	21.80	21.90	22.20	21.60	20.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-8.95	0.72	-3.94	43	302	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	243	7	199	288	2	48.60	48	61.89	CHANGED	ppKP...KsCCsC.-pKcsRD-Cll...pGp-p.....CpchIEtaKpCM+uhGFpl	..........p.pKP...hKPCCsCP-TKcsRDp.Cll.....pGp-s........CtphIEsHKpCM+uhGFpl.............	0	65	105	163
+1641	PF00431	CUB		CUB domain	Bateman A, Finn RD	anon	Pfam-B_136 (release 1.0)	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.53	0.72	-3.98	29	12961	2012-10-02 11:50:15	2003-04-07 12:59:11	15	883	190	46	7617	11572	76	107.50	26	32.62	CHANGED	CGsp....lppssGslpS.PsaPp.sY.ssppClWpIpss.uhp..lpLpFps.F-lEtpt.......ChYDalElhDG.tss.t.hlG+aCG.....pthPssltSsusphhlpFho.DsshsppGFphsa	......................................................................Cut......hp..t.....s....G...h...lp...S...P....s.......a....P.......p........s...........Y......s........s......s.....h...........p.....C..h.......Wt..........I......p....s......s..............s.....p.....p...............l...p...L......p.....F..p......p...F...p.l...E.......................................C....t.......h....D....a......l.......p........l.....h.....-...............G......s............s...............t...............p........s.......................h...........l.............u.......p............a.............C....G.......................s.p..h..P...t....s.....l......h...S......s....u.....s.......p....l..hlpF...p......o......D.....t....s.....h.....s.....t...p..GFphpa..............................................................................................	1	2339	2836	5004
+1642	PF00116	COX2		Cytochrome C oxidase subunit II, periplasmic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.47	0.71	-4.28	32	31269	2012-10-02 17:41:00	2003-04-07 12:59:11	15	29	18166	144	1320	28095	2586	106.00	48	47.64	CHANGED	lTlKulGHQWYWSYEYsDa.s.....lpFDSYMlPpppLp.sphR....LL-VDNRhllPhssplRhllTu....sDVlHSWslPShGlKhDAsPGRLNQsohhh...sRsGlaaGQCSEICGsNHSaMPIslEul	................................................................lTlKslG.HQWYWS...YE..Y...o..D..a....s..........................l..p.F..D.S...Y.......M....l.........s..........p......p........-.........h..............................s.p........F.......R.............................LL..-.....VD...N.....R.l.....l..lP..hsspIRlllTu......s.D....V....l...HSWs...l....P.....u........L..G....l....K........h........D..A..s..P.....G.....R........L.N...Q...s...s...ahh....................sR...P......G......l...a.a......G.QCS.ElCG......ss.Hu.h.Ms.hhh........................................	0	349	789	1076
+1643	PF02790	COX2_TM		Cytochrome C oxidase subunit II, transmembrane domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	The N-terminal domain of cytochrome C oxidase contains two transmembrane alpha-helices.	21.00	18.00	21.10	19.70	20.80	17.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.03	32	25391	2009-01-15 18:05:59	2003-04-07 12:59:11	10	24	16352	78	555	22832	1763	78.90	47	36.87	CHANGED	MsT.hshs...hQDuuSPhMEplhhFHDashhlLhhIhhhVsalhhshlhs......phsp+ahlcGQh.IEhIWTllPAllLlhIAlPSL+L	............................Msp..phs....h..Qs...usSPlMEp.Lla.F.H.DHs..l..h..I....l...lh...I.o..h.l...V....s..Y.lh..h..h.l.h.hN................................K.hs.s.+...h...ll.-u.Qh...IElI.....WTIlPAllLlhIAlPSLRL................................................	0	162	342	451
+1644	PF00510	COX3		Cytochrome c oxidase subunit III	Finn RD	anon	Pfam-B_78 (release 1.0)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.69	0.70	-4.94	21	13171	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	8530	60	1326	11262	3530	206.40	41	93.84	CHANGED	HPFHlVssSPWPlssShuhhshsluhlhahHsap..hhllhlullsllhsMhhWaRDllREuTapGpHThhVpcGL+hGhlLFIlSElhFFhuhFWAFFHSuLuPolELGusWPPhGI..pslNPh-lPLLNThILLoSGsTlTaAHHullpG.pRppul.uLhlTllLulhFThhQhhEYhpAsFTIuDuVYGSsFahuTGFHGlHVllGTlFLhVshhRhhpaHhTspHHhGFEsAhaYWHFVDVVWLFLYlolYWWGu	.........................................................................................................................................................................................................................................................................................................t.t..............G....Hs..............l.............u..h.+..h..........G...hh.LF.Ih.S.E.l.hF.....Fhu.a.F....WA..........a......a...................p.........u.................u....L........u..........P..............s.....................................p........l.................G.................s............h....................W..P...........P..............t.......G.......l.................p..s.......h...s....P....h...p...l..........P......L....L....N..Thl....LLuS......G...l.o....lT...........a.........A...HH............u...........l...........h.......p.............s.............p.............c................p......p........s..............h.t.u..........L.........h.l.T..l..l...L.GhhFsh..l...Q...s...h...E.........Y........h..........c..............s...........s.........F................o.........l.......u.......D..............u...........l...........Y.........G......S.......sF...F....h....s..TG...FH.GlHV...ll..G.oh.aL...h.......l..sh....h...R..........h...........h.........h......c.........a........o...........s..........p...........p..........+..........h..........u..........h............c...s.....su.........h.......YWHFVDl.VWl.h.lah.lYh...................................................	1	358	800	1075
+1645	PF02284	COX5A		Cytochrome c oxidase subunit Va	Mian N, Bateman A	anon	Pfam-B_7466 (release 5.2)	Domain	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit Va.	21.30	21.30	22.00	25.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.43	0.72	-4.10	3	318	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	272	51	176	300	0	103.20	52	69.73	CHANGED	uHGoEETsEEFDARYEKYFs+EuIDuWElRKGMNsLlGYDLVPuPKIIEAALRAuRRVNDlAoAIRlLEulKDKsGscKt.lYPYlL-EL+PTLQELGIPThEELGhDK	......................H..pp.E.T.EEFsA.R......a.phFs.sshDsaElp+uhNs.hhuYDLVPpPcllpAAL...RAs...RRlNDaAoAVRlhEulKsKst.s+.c.....YshhlpEL+PshpELGIsh.EELh.-..............	0	51	86	139
+1646	PF01215	COX5B		Cytochrome c oxidase subunit Vb	Finn RD, Bateman A	anon	Prosite	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.69	0.71	-4.50	4	403	2012-10-03 19:45:42	2003-04-07 12:59:11	14	3	288	52	248	395	7	118.00	33	69.68	CHANGED	S+ll+t.pslsp.suQsLt.s+tPs..oLltshuptGtVPTDh-QtTGLcR..hLuthpGpDsFshcsLcuo.pGThcDPllVpSlsshRhVGCpGususSHsllWhpltcscspRC.-CGoVYKLp.hus.scphtH	................................................................................................u....tls.....s-..-.p....ATGL.E...RhEl..lu.p.h..p.G.h.D.s......a.c....h.c.s..cus..hG...T.h-s...PhlV.s.Sh..hscRlVGCss....t....t.s.s.o..slhWhhl.c.c.s.c.s.p.RCspCGp.haKL...............................	0	84	137	203
+1647	PF02046	COX6A		Cytochrome c oxidase subunit VIa	Mian N, Bateman A	anon	IPR001349	Family	\N	25.00	25.00	28.10	27.90	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.92	0.71	-4.17	31	404	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	264	51	247	396	1	102.90	34	78.21	CHANGED	Mht.............t..t..........sh+RhhSo......................sstt.......tpta.pphtth.tHutu...soclW++loh.....hlAlPu.lslsulNsa.l..cscHt-HhtH.....-p-phspYsa.NIRoKsF.WGDGsKTLFWNscVNths	........................................thhhts.................................................................t...shtt..c.sts...su.....ch..W+p.loh.....h....lul.Pu.lslshlNsa.l.pcHtcH.....................tp.EhstYsahp..IRoK.sFPWG.DG.s..+.o........LF........aNsclN.h.s..............	0	67	115	186
+1648	PF02297	COX6B		Cytochrome oxidase c subunit VIb	Mian N, Bateman A	anon	Pfam-B_9188 (release 5.2)	Domain	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the potentially heme-binding subunit IVb of the oxidase.	24.50	24.50	24.80	25.40	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-9.88	0.72	-3.96	58	675	2012-10-02 15:44:21	2003-04-07 12:59:11	12	9	292	51	456	646	0	66.70	32	59.76	CHANGED	schPs.........pspp+pCapshscaacClcp...pu........................spp................Cphhppsacs.CssuWlchac-p.....pcpshhs	....................RFPs..psQp+pCap.......sas-aa+Clct...psp......................................shss...............Cc.tatcsacohCPts......W....l..ccac-p......tt....t.................	0	125	227	364
+1649	PF02238	COX7a		Cytochrome c oxidase subunit VIIa	Bateman A, Mian N, Finn RD	anon	Pfam-B_3023 (release 5.2)	Family	Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the heart and liver isoforms of cytochrome c oxidase  subunit VIIa.	22.20	22.20	22.50	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.73	0.72	-4.24	8	306	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	111	51	138	301	0	53.40	42	59.85	CHANGED	+NKVhEKQKLFQpssch.sYLKGGh.DslLaRlTMsLslGGTuYslhuLGhAuhP+s	......pN+Vs-tQKhFQcsss..lPlaLKGGhsDs.lL..Y..RsT.Ms....L.....s...l...u........Gohhslh.thhhhs.s+t..........................	0	21	42	77
+1650	PF02285	COX8		Cytochrome oxidase c subunit VIII	Mian N, Bateman A	anon	Pfam-B_6423 (release 5.2)	Family	Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIII.	20.50	20.50	20.60	20.60	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.98	0.72	-4.43	11	112	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	71	51	45	114	0	42.40	43	59.90	CHANGED	VpSKPs+p.hushEpAlGloshFVoFLlPAGWlLSHLEsYKKpu	.....lpSpPscp.plushEpAl.GLoshFlshLlPuGWlLuHL-sYK+.....	0	5	7	16
+1651	PF02672	CP12		CP12 domain	Bateman A	anon	Bateman A	Family	The function of this domain is unknown, it does contain three conserved cysteines and a histidine, that suggests this may be a zinc binding domain (Bateman A pers. observation). This domain is found associated with CBS domains in some proteins Pfam:PF00571.	21.20	21.20	21.20	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.40	0.72	-3.51	39	291	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	151	16	114	305	584	62.40	34	39.64	CHANGED	ls-pIpcshpcAcpsCups..sSucCssAWDtVEELpAttuHpcpcpp....ppssLEpYC--NP-AsECR.lYDD	...................................tpplppthppActhsstt..ssspsttAW-t.l-ELpsttsHt.tpt......stssLE.....paCcsNP-ssEC+.lY-p...................	0	24	78	103
+1652	PF01383	CpcD		CpcD/allophycocyanin linker domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_887 (release 3.0)	Domain	\N	21.10	21.10	21.30	23.20	19.30	20.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.36	0.72	-3.79	86	448	2009-01-15 18:05:59	2003-04-07 12:59:11	16	9	103	2	124	392	105	55.10	34	24.05	CHANGED	u..RhFplcVsu.........tt...h.R+Sspshl.VPaschspphQcIp+hGG+IlSIsss	.........RhF+lcVsu.........tppp.pl.R+ospsal.VPYsphspphQRIpRhGG+IlSIpsh....	0	14	77	114
+1653	PF00166	Cpn10	cpn10; 	Chaperonin 10 Kd subunit	Sonnhammer ELL, Finn RD	anon	Prosite	Domain	This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis [1]. 	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.12	0.72	-4.05	48	6057	2012-10-01 22:45:51	2003-04-07 12:59:11	16	6	4946	114	1577	3685	2838	90.70	44	92.00	CHANGED	plcPLtDRVllct..h.pt.-p...potuGIllP..-supc..Ks..ppGpVlAVGsGhh..ppGp.hhshslcs..GDpVlascau.............Gs.clch..-.sccalllcppDIlAll	....................l+PLtDRVll+t....h..Es.Ep...cTs.uGIl.lP.....soApE....Ks...ppGc.VlAVGs.G...............p.h...................c..........s............G..........p..h..........hs.h.s.VKs...GDpVlas.cau....................Go.-lch........-.sc-aL.....lhp.EsDILAll................................	0	540	1020	1322
+1654	PF05205	COMPASS-Shg1	Cps15; 	COMPASS (Complex proteins associated with Set1p) component shg1	Wood V, Coggill P	anon	Wood V	Family	The Shg1 subunit is one of the eight subunits of the COMPASS complex, complex associated with SET1, conserved in yeasts and in other eukaryotes up to humans. It is associated with the region of the Set1 protein that is N-terminal to the C-terminus, ie Set1-560-900. The function of Shg1 seems to be to slightly inhibit histone 3 lysine 4 (H3K4) di- and tri-methylation, and it is a pioneer protein. The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for silencing of genes close to the telomeres of chromosomes [3].	22.10	22.10	22.10	23.40	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.43	0.72	-3.75	22	260	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	195	0	177	248	0	106.20	31	17.20	CHANGED	cpLsctaKKcGtFDphR+clLsch.cpu...........-tcpplpp+ltpllcsclpc-s.plL.+s+G+susLIcGtls+s............................shhpt..........s-pslss..ll-pclpch..tslcphh+ptltc-	................llpphKpcGhFDphR.+-sLu-h.csp..............suhpsLpp+lcshVpscls.cpp......shN+..sphpshl.ctplhcS............................hl..ps............s-ch....lsp....llcs+lsch..hsplcphh+p.l...t.....................................................................................	1	43	76	128
+1655	PF00289	CPSase_L_chain	CPSase; 	Carbamoyl-phosphate synthase L chain, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117.	25.50	24.50	25.50	24.50	25.40	24.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.17	0.72	-3.96	157	23989	2009-01-15 18:05:59	2003-04-07 12:59:11	17	163	7729	193	5850	19831	8081	108.40	33	18.02	CHANGED	hhc+lLlANRGEI...........AlRlhRss+ch.............Gl.coVslaoss..Dpsuh...asphADcshhls..s...s.........tuYLsh-pllpsA..cps........G.....spA.lHPGYGFLSEsscFActst..p.tGl..hFlGPsscsl	...................................................................hc+lLlhs.pG.I...............................ulpsh+uh+-h..................Gh.col.hV.ss.ss.............-..o..sus.............chph......AD.c.....s..Yh.s...............................lsh.-tlhplhchp.........................u...s.s...ha........sG....sh.Ls.s.hph..tp...h..........c..tGl....hhlGssscsI......................................	0	1856	3641	4921
+1656	PF02786	CPSase_L_D2	CPSase; 	Carbamoyl-phosphate synthase L chain, ATP binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Carbamoyl-phosphate synthase catalyses the ATP-dependent synthesis of carbamyl-phosphate from  glutamine or ammonia and bicarbonate.  This  important enzyme initiates both the urea cycle and the biosynthesis  of arginine and/or pyrimidines [2]. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a  heterodimer of a small and large chain.  The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesise carbamoyl phosphate. See Pfam:PF00988. The small chain has a GATase domain in the carboxyl terminus. See Pfam:PF00117. The ATP binding domain (this one) has an ATP-grasp fold.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.13	0.70	-5.05	16	23031	2012-10-10 13:17:03	2003-04-07 12:59:11	12	179	6767	194	5911	27500	13103	197.30	32	31.79	CHANGED	D+tthpsthschshPssPusss...coh--AlthAcclGYPVII+uAauhGGpGhtlspsc-Eltclhspuhspu......splLlEK.lcs.KcIEhpVlpDupsNsIplsshEs.s.h..+stcsl.hAPSpTLo-cphphl+psAlpls+clGhhGus.slpahlss..stcahhIEhNsRlphppslupcsTGhsLshhthKlAhGhsLspl	.............................................................................................................D+tthpp.h.h..pc..h..s..ls.......h........s.............ut....t...s........................p......s..........h.......-......-...........A............h.............t........h............A.......c.........c..........l.............G....Y...P...l..l......l.......+.......s.u.......h.......s........h........G.....Gp.........G.......h....p........l.........s.........p.......s....c.......c...........-.........L....p................p.h..h.................p.......p.................u.......h.................p.................t.................u...................................................................................s.......s.......t.................l...........h.......l..-.+.h.l....t....s........s....+......c....l......E...l........p......l.......l........s....D.......s.......p........s.........N.........s.........l........h.......l.......s.......p......h..........-......s............pt................+s..t........c.....s.............l......p.............................u.......P.......u.............................s.............L......o........s.................c................h.....................p.........t......l....t....p..s....u..........h....p....l.....s...........+t....l.....s.....h....h...G....s..s.....s...l...p..F.......h.......l.........s...............................s...........s..................c...........h...Y..hl..E........hN.s....R....l...p.......h....p...p....s...l...s...p..p...s.........T......G.........h.....s.....lschth+.lA.hG.sLs..h..................................................................................................................................	0	1878	3684	4980
+1657	PF00650	CRAL_TRIO		CRAL/TRIO domain	Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.70	0.71	-4.74	110	4026	2012-10-02 01:12:42	2003-04-07 12:59:11	15	76	365	19	2809	4545	94	152.30	20	37.53	CHANGED	th.hptththlhGh.DppGRPlhhhcht.thssp....sts..t......................phhchhlhhhEpsh..................hhtt........thsshsllhDhpshs.....htphs....hshh.+hllphhp.spYP-pLtplhllssPhhhsshapllp..sal.sspsppKlpht.pstp...........Lppals...cplsp.......phG.Gp	....................................................................................................t......h..h.h...th..D...p.p.Gcslh..hhphs..ph.ssp................phs...p.........................................ch..h+.h..h.hhhhE..thht.....................................................h............................thp...shshlh.Dh..p...uhs..............h.p.p.h...t.............hphh...p.......p....h....hph..h.......p....stYP...p...plt..p..h...hll...........N.......s....P...h......h.a...p.s.ha.p..l...........l+................sa.l..s.........t.ps...t..pK...lhh...h...ts..t.t..t..........tLhp..h..l.s.........p.LPp.......phGGp.............................................................	0	1013	1571	2350
+1658	PF03765	CRAL_TRIO_N		CRAL/TRIO, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This all-alpha domain is found to the N-terminus of Pfam:PF00650.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.54	0.72	-3.83	148	2100	2009-01-15 18:05:59	2003-04-07 12:59:11	10	27	310	19	1402	1996	17	56.30	25	13.53	CHANGED	pptlpp....lcphltp............................thhptph..............sD..thlLRFLRARcaclpcAhpMlpps	...............................................................................................................h.p...hcphltp...................................t.hhttph...................................................sD...thLLRFLRARcFclpc.Ahphltp..............	0	364	715	1092
+1659	PF02537	CRCB		CrcB-like protein	Mian N, Bateman A	anon	COGs	Family	CRCB is a putative integral membrane protein possibly involved in chromosome condensation. Over expression in E. coli also leads to  camphor resistance [1]. 	22.70	22.70	23.10	22.90	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.59	0.71	-4.21	106	5746	2012-10-02 19:55:49	2003-04-07 12:59:11	10	8	3698	0	1390	3815	1350	112.50	30	83.00	CHANGED	hlhlulGGslGAhhRahlsthh.p.........................uTl.hlNllGsallGhhhs.hh..............htth...hphhlssGFhGuhTTFSoash-shplhpps.phh.tuhhahhholhhGlhsshhGhh	...................................lhlhlGGulGulhRahluhhhst...hhssh.................................PhGTL.hlNllGuFllGhhhshhh......................................tthssthphh.....lsTGFhGGhTTFSTFshEsl...p.L....h.pp.........s.....p.........h........h.....huh...h.al...hhollhul.hhshlGh.h..........................................	0	430	866	1175
+1660	PF01321	Creatinase_N		Creatinase/Prolidase N-terminal domain	Finn RD, Bateman A	anon	Bateman A	Domain	This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.87	0.71	-3.66	170	7541	2012-10-02 11:23:57	2003-04-07 12:59:11	13	18	4001	40	1991	5872	3626	132.50	18	31.80	CHANGED	Rlpclpphhpcps..lDuhllsss............tslhYloGa.........ssstshhl.l......st.cs..t.h...................llss.hchtpttppp...........hcl.h.hpp..................hpslhphltph.........h.t..............ppl.G...hEtsh.....hshst...hptlppth.....t...phhshss....hlpplRhl	.....................................+lpplpphhp..p..p..p.......lD..uh..llsss................................................tshtYlo..GF...................sssss.hs.l...l................st...-p...s...h.......................................................lhs..c...hch...httsppp.......................shpl..hthps........................................................hpslt..p.h.ltph..........................................................h.t................ppl..u..........h-..s.ph..............loh..st.....h..p..p.Lppth..........st.......ph.h.shs.......h.t.hR...................................................................................................	0	667	1256	1650
+1661	PF00030	Crystall	crystall; 	Beta/Gamma crystallin	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	The alignment comprises two Greek key motifs since the similarity between them is very low.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.58	0.72	-4.09	138	3340	2012-10-01 23:14:22	2003-04-07 12:59:11	14	52	213	141	1708	2532	18	81.10	31	53.48	CHANGED	+lplaEcpsFp..GcphEhs.sDs..sslpphhh.sc............lpSh+V.s.GsW.lhYEpssapG..cQalLc....pGEYtsapp.W.G.....ssp...........ltShRhl	....................................plhlaEcp.sFp....G.c.phEhs....s....Ds........sslps.h.....h...a.sp...............spSl+.V.s..G...sW....l..hYEpssap....G......pQa.lLc........p.G.-.Y.....p..a..pp...W..G........t.ss.p.........................ltShR.l.........................................	0	133	378	969
+1662	PF02633	Creatininase		Creatinine amidohydrolase	Mian N, Bateman A	anon	COG1402	Family	Creatinine amidohydrolase (EC:3.5.2.10), or creatininase, catalyses  the hydrolysis of creatinine to creatine [1]. 	24.40	24.40	24.60	24.50	23.90	24.30	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.52	0.70	-5.28	163	1362	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	981	81	528	1293	626	234.00	26	90.37	CHANGED	hsphoh..s-l.pph.....tpt..sssllPlGu.sEQHGPHLPluTDshlupslupcsspphs................shlhPslsh......Gh..SscHh.s.....FP...GTlolsspThhsl.lp-lscSlt.ppGh++llllNuHGG..Nhshlphsscclptc............shhlhshsaaph..s..t........hhsthttptshHAGthETSlhLtl....tP....-hVchs+.............................ts.thhsht..thhhshthpc...hsssGshG...-sst..AoAE....+Gctlhcthscthsphlp	........................sh.-htth......tps.....sssllPlGu.sEQHGPHLPluTDshlupslu...pp..lspphs................shlhPslsh....................Gh.....u...c.Hh.s........................aP.....G.T.lolss.pshh..sh.lt-lscult.p.pGh...++...........llhlN................uHGG..........Nhss....l.pts...spclptc................................shh.h.h.h..h...s.a.h.ph....s.........................h.t..t.t..t.ts...hHAGthETSlhLtl....tP.-h.Vchsc............................h.t.t.hhp.h.t....sh.hhs..hthpp.....hsss.....G.shG...csst...Aos-......cGctlhpthspthsphl......................................................................................	0	165	359	459
+1663	PF03858	Crust_neuro_H		Crustacean neurohormone H	Finn RD	anon	DOMO:DM02710;	Family	These proteins are referred to as precursor-related peptides as they are typically co-transcribed and translated with the CHH neurohormone (Pfam:PF01147).  However, in some species this neuropeptide is synthesised as a separate protein. Furthermore, neurohormone H can undergo proteolysis to give rise to 5 different neuropeptides [1].  	21.00	21.00	21.10	21.00	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.00	0.72	-3.37	8	51	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	23	0	0	56	0	38.60	54	29.06	CHANGED	RSA-GaGRM-RLLASL+Gsu-o.sPLu-LpGA.E.uuuHPLE	RSApGaGRM-RLLASL+..u-s.sPlusL..s.E..ussHPLE..............	0	0	0	0
+1664	PF01147	Crust_neurohorm		Crustacean CHH/MIH/GIH neurohormone family	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	26.20	25.00	23.70	24.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.08	0.72	-4.67	45	264	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	93	1	38	277	0	69.90	40	61.43	CHANGED	plaDpsC+Gla.sRslFp+L-RVC-DCYNLaRcsplsotCRpsCFsNphFttClcsLhh.c.phccapphlphl.s	........................haD.sC+Gla.DRslFp+L-RVC-DCYNL..a..R..p..stlsstCRpsCF.........sNphFttClcsLhh..-..phcphtthlphl................	0	12	15	35
+1665	PF00525	Crystallin	crystallin; 	Alpha crystallin A chain, N terminal	Finn RD	anon	Pfam-B_97 (release 1.0)	Family	\N	23.20	23.20	23.20	23.40	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.29	0.72	-3.76	11	395	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	264	24	81	297	0	51.50	65	39.75	CHANGED	MDIsIQHPWhRRPhas..aaPSRlFDQhFGEHl.-uDLFPsh........sslSPaYh+...P.hhRhPS	..........................R.....u...LGP....hhPSRLFDQFFGEGLhEYDLLPhh.............SSTISPYYRQS.....LFR...oV...............	0	5	12	29
+1666	PF03783	CsgG		Curli production assembly/transport component CsgG	Finn RD	anon	COG1462	Family	CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.25	0.70	-5.25	61	1246	2012-10-01 20:48:06	2003-04-07 12:59:11	9	33	1090	0	274	845	586	190.90	30	65.37	CHANGED	tshshsth+hsluVhpF..cspou........at.s..........SshsssluptusshLlstLppo...stFsllERpsLpslhpEppl...............ssphssLpuAshllpGulspaspss.t.tsG........hphhGlhu......psphppshspVsLRlVslpTucVlhSspssuchtspshpsu..............................hhthhsu.suhhsscslslAlppAlpp..hVptl.s.th.tuhWp..sp	.......................................................................s..h.hsss+h.luVhph..pscou..............a..h.h........Sshsstlsppu.psh.....Llo.t.L..p..p..S....p.h..F.hsL.E..R..p..s..L.pslh.p.Epplhps.s..p............s.pph.l........psLpu.AshhlpGuI........h..s.......ap.spst..s.st.lG..............tphaGIhu...........................................ss.phpls.pht..VsL+lVsVsTu.Ell.S........sp.sutphh..phpss..............................h.th.htu....uhhsscsl.lslhpAlpphV.hl.s.Gh.p......s................................................................................	1	75	168	224
+1667	PF02599	CsrA		Global regulator protein family	Bashton M, Bateman A	anon	COG1551	Family	This is a family of global regulator proteins. This protein is a RNA-binding protein and a global regulator of carbohydrate metabolism genes facilitating mRNA decay [1].  In E. coli CsrA binds the CsrB RNA molecule to form the Csr regulatory system which has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis [1]. In other bacteria such as Erwinia caratovara RmsA has been shown to regulate the production of virulence determinants, such extracellular enzymes [2]. RmsA binds to RmsB regulatory RNA.	20.70	20.70	20.70	21.60	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.60	0.72	-4.24	137	1995	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1669	7	426	998	255	53.20	54	75.78	CHANGED	MLlLoRKhGEsIhI...G.D.-IpIsVlplc..Gsp....V+lGIcAP+slslaRcEl......YpcIppc	.............MLILTR+lGEolhI...............G.D...-l.sVT.VL..u.V+...GsQ....VRIGlsAPK-VuVHREEI..Yp+IptE...................	1	175	279	361
+1668	PF02554	CstA		Carbon starvation protein CstA	Bashton M, Bateman A	anon	COGs	Family	This family consists of Carbon starvation protein CstA a predicted membrane protein.\	  It has been suggested that CstA is involved in peptide utilisation [1].	25.00	25.00	28.10	27.70	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.31	0.70	-5.81	97	3680	2012-10-03 01:44:59	2003-04-07 12:59:11	9	5	2335	0	644	2537	205	319.50	39	60.88	CHANGED	h.sulhlllsulssahluYRaYupa.lup+lht.lDssRtTPAcphpDGhDYVPTs+h.VLFGHHFAuIAGAGPlVGPllA.AtaGaLPuhLWIllGslhuGAVpDahsLahShR+cG+SlGpls+cplGphushhhhlhshhlhllllAlhuhlVspsh..............sp...........oPh.....................ushslhhsIPlAlhhGha...hah+suplhtsSllGllLlhhulhhGhh.ls........................................hh.hstpphsh..llhsYualAolLPVWlLLtPRDYLooahhluslshLslGlll.....stPplphP.AhTp......F.h...sGssPhhsG...slFPaLFITIACGAlSGFHuLluSGTTsK.lspEscs+hlGYGuMLhEuhlAlhAllAAsslt....................uhYauhp......................................................................Ghs.....sstlsphup....slG	............................pshhhllsulshhhluYhhYuha.l..tpplh..l.-..ss.R.hTPAhh.sDGhDYVPss+h.llFGHHFuu..IAGA.GPllGPlLA.A.hGalPuhlWllhGslhAGAVpDahsLhlShR+sGtSluphhpcphG.hsthlhhhhshhlhlllhAVhu.....h....llspsL................s.t............sPh..................................................uhhs.lh.hlslAhhhGhh...hhhts...sp..hh.hohlGhhhh.hhslh.G...l.........................................h.hptsthsh..hlhsYsFlAulLPVWhlLuPRDYLsoahhlssllul.sl.Glll...................htPpl..p...hP...uhop.....a.h................ssssP..h..hsu............slFPhLFITIACGAlSGFHAhluSGTTsKhlt.............pEppuphlGYGuMlhEuhVAlhAhluAs.h.l.........su.hh.th...............................................................ht.s..hh.............................................................................	0	219	401	536
+1669	PF00859	CTF_NFI		CTF/NF-I family transcription modulation region	Bateman A	anon	Pfam-B_362 (release 3.0)	Family	\N	19.50	19.50	20.10	19.70	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.12	0.70	-4.65	4	440	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	51	0	132	328	0	227.10	51	56.35	CHANGED	QDSFVTSGVFSVoELVRVSpTPIssGTGPNFSLuDLpSpsYY.shsPGu..hRRoLPSTSSSuS.KRhK..SME--hD.SPGt-saYo....SPuSsopSS.sWHE.hEsuhsSP.phpc.-Ks.FsssSPpppSshhSuFsQ+H+Psl.....os.tsSPHso.SsLHFPTSsIl.QpPuoYFsHsAIRY....pPQ-sLK-aVpLsCssuuQQuGQ.....PNGSuQ..GKV.s.FLsTPMLsPPPP..PshARPVsLshPDTKPsTTSTEGGusSPTSPoYSsPuTSPANR.FVulGPRDPuFl...pQsQSWYLG	...............................................pDsFVpSGVFsVoELVRVSpTPlssGo.....GP.NFSlu-.L...pSp.sY.Y..s....hss......u.....s.....h+RSLsSssSo............ss.K........R...K.........Sl-.-.pM-...SPst-..........FYs....SPu...ususu.S.t.sWp-..h-.............s.................s.............h......su.P....ssh....KKs.tK...FsS.sosppsSshh.sFspHt.hPs..l.....ss.....ssSP+so..sSsLHFPoosIl..QpsusYFoH...PsIRY...hpP.QDsLK-aVphsCs..s.u..u.tQ.s.u.p.........................suusQ...+h..s.h....hLsPs........P.......h.h............................t...........................................................................................................................	2	9	23	64
+1670	PF01467	CTP_transf_2	Cytidylyltransf; 	Cytidylyltransferase	Bateman A	anon	Bateman A	Domain	This family includes: Cholinephosphate cytidylyltransferase Swiss:P49585. Glycerol-3-phosphate cytidylyltransferase Swiss:P27623.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.99	0.71	-4.17	65	14199	2012-10-02 18:00:56	2003-04-07 12:59:11	21	74	4889	196	4168	10545	6936	142.60	19	60.12	CHANGED	lhsGoFDPlHhGHlpllcputphhs......llhlssspsspp..p....shhstpcRhchlctshtsst.....................................................h.hlhstc.....................hpthpchltchphshhs+s.s..thpt.....................t.....hhhhhhh.htp.......lSootl+pt	.......................................................................................................lhsGoFDPlH..h.........GHl.shlppA...t......p.....h......h.......c.........h..........................llh..ls....s.s..t....s..s..p.+...p............................shh.s.h.ccR....hth....l....p....t......s....h......t.....s........................h...........h.......p.......................................................................................................................................................................t.......h..hl..h.ttc.........h...........................th..p..th....p..c..h..h...t......p...h......p.....h...s...h..hs..+.s...t...th.pt.h..........................................................................................h..h.........h.................lSoo.l+p.h........................................................................................................................................................................................................................................	0	1392	2560	3483
+1671	PF02348	CTP_transf_3	Cytidylyl_trans; 	Cytidylyltransferase	Bashton M, Bateman A	anon	Pfam-B_886 (release 5.2)	Family	This family consists of two main Cytidylyltransferase activities: 1) 3-deoxy-manno-octulosonate cytidylyltransferase, [3], EC:2.7.7.38 catalysing the reaction:- CTP + 3-deoxy-D-manno-octulosonate <=> diphosphate + CMP-3-deoxy-D-manno-octulosonate, 2) acylneuraminate cytidylyltransferase EC:2.7.7.43, [1,2], catalysing  the reaction:- CTP + N-acylneuraminate <=> diphosphate + CMP-N-acylneuraminate. NeuAc cytydilyltransferase of Mannheimia haemolytica has been characterised describing kinetics and regulation by substrate charge, energetic charge and amino-sugar demand[4].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.47	0.70	-4.71	20	4289	2012-10-03 05:28:31	2003-04-07 12:59:11	14	33	2780	54	1074	4236	6196	213.60	26	80.94	CHANGED	lsIIPARhuSpRL.sKsLtpltGcPllt+slcsAhpSthh-+....llVATDscpltchsppaG..spshhpssshsssscRshcslcchhss........hllslpGDpPhLpspsltphhppltps.t...................hsshstsls.sppshpssslcsshcpp......shthahpcushsahpcp.s.................hhtchulYsaRpt....hhhcaststsos...........hc.hcpl.........cQh+.....hhhtu................pcI	.......................slIPA.Rh...uSoR..l...P.....s....Ks...Lt....c...l......s...G.....K.....P..hIhash.-...p....A.....t...p.u....s...t....h.c.c.........l.l..V...A...T.....D....c...c...c....l....t....p....s....s......p....t.hG..........scl.h..h.s....p...s.c..p.t....o....u....o.....c.......R....h....s...-..s....l..p.c...hshs.....tp....................llls..l...Q.G....D..p....Phlssshlpp....sh..p...t..l...t..ps...s...........................................................th.s.o...h...s...h.........l....t........t....t....p........c...h...h..s........s...s.s......l.K...s....l....h..ctp..................s.u...h...a...a.o+ss..lPa....+....p.t...t.....................................................hh.t+..l.u...lYsactt...........hl.pas.t.....s....................hE.hE.l...................-ph+.....hh.....................................................................................................................................................................	0	335	680	894
+1672	PF04808	CTV_P23		Citrus tristeza virus (CTV) P23 protein 	Kerrison ND	anon	Pfam-B_2595 (release 7.6)	Family	This family consists of protein P23 from the citrus tristeza virus, which is a member of the Closteroviridae.\	 CTV viruses produce more positive than negative RNA strands, and P23 controls this asymmetrical RNA accumulation. Amino acids 42-180 are essential for function and are thought to contain RNA-binding and zinc finger domains [1].	20.70	20.70	21.00	20.70	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.44	0.70	-5.01	3	175	2012-10-01 20:03:16	2003-04-07 12:59:11	7	1	1	0	0	178	0	204.80	91	100.00	CHANGED	MDNTSGQTFVSVNLSDESNTAST-VEsVSSEADRLEFLRKMNPlIIDALIRKNSYQGARFRARIIGVCVDCGRKHDKALKTERKCKVNNTQSQNEVAHMLMHDPVKYLNKRKARAFSNAEMFAIDLVMYTKERQLAVDLAAEREKTRLARRHPMRSPEETPEHYKFGMTAKAMLP-INAVDVGDNEDTSSEYPVSLSVSGGVLREHHFI	......MDsTSGQTFlSVNLSDESNTASTcV+sVSSEADRLEFLRKMN.PFIIDALlRKTsYQGARFRARIIGVCVDCGRKHDKu.+TERKCKVNNTQSQNEVAHMLMHDPVKYLNKRKARAFSNAEMFAIDLVMYTKERQLAVDLAAEREKTRLARR.HPMRSPEETPEHYKFGMTAKAMLPDINAVDVGDNEDTSSEYPVSLSVSGGVLREHHFI......	0	0	0	0
+1673	PF01179	Cu_amine_oxid		Copper amine oxidase, enzyme domain	Bateman A, Finn RD	anon	Prosite	Domain	Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ). This family corresponds to the catalytic domain of the enzyme. 	19.70	19.70	20.10	21.40	19.50	18.30	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.16	0.70	-5.75	75	1272	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	545	187	699	1240	205	371.60	33	57.94	CHANGED	Plpl....sQP-GsSFpl.c.....GptlpWppWpF+lGFssREGlsLaslpapscs.........lhYRlSlsEMhVPYGDPpssahpKpsFDsG-aGhGhhussLplG......CDChGt.IpYhDuhhssssGpPhplcNulClHEpDsG.lLaKHoshcs..s.ps.tspRsRpLVlphIsTluNY-YhahahFhpDGsIchEl+ATGIlsoss........hss.....spp.....ss...aG.shVs.sslhushHQHlFshRlDhslDG...t.p....Nolhth-shshsh.......sstN..Phusuapsccphlcsttpu..thchssppsRhaclhNssppN.h.GpPsuY+lhs......ssssh...llspssShhtpRusFAp+plWVTtYc-s.....EhauuGpassQssus......sGlssaltp...scs.......lcspDlVlWaThGhpHhP+sEDaP..VMPs-hhuhhL+PhsFFspNPuLDlPsssp	...........................................PhplhpPcGssapl..p......Gphlp.WppWpF+lu..hs.RtGhhl.slpapsps...........lhYchSlsEhhVPYu..sPp....sahh+thhDhG-aGhGhhsssLthG.................pDC..u.t.h.....tahDs.hhss.t...sGtPht.h...su.....lClaE...p....s.sG..ha+...Hppht...............t...s...hstcp+pLVlphlsTluNY-Y........h...........asahFtp...sGsI......phcspuTGllssts.......................hss..t..ts.....s....aG.ohls...slhushHpHha......shRlDhsl...D....G...........t...p....N.o.lh.t..-.s...hs...h.s....................sst..s..s.h.....s...ssh...p...sp...pph....lpsE.tpu..thch...sstp.sRhhhlsNss.ppNth.Gps.........suY+lhs......ss.st.h....hhhs.ss.s.h.hh.+R.ssF.sc..................pp....laVTpY..ccs......E.....hasuGtassps.ts..............suls.paht..p......scs..............................l.....c...s..p...Dl......VlW...hT..................hGhpHhP+s..EDaP..lM..P..s..p..hh..sh.hL+PhsFFspsPslss........................................................................	1	162	358	544
+1674	PF02727	Cu_amine_oxidN2		Copper amine oxidase, N2 domain	Bateman A, Finn RD	anon	Prosite	Domain	This domain is the first or second structural domain in copper amine oxidases, it is known as the N2 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.76	0.72	-3.90	14	944	2012-10-02 11:54:05	2003-04-07 12:59:11	11	27	479	119	492	882	81	87.20	27	12.37	CHANGED	HPL-sLostEhs+spsIlpsps.hsts.shphp.lsLc-PcKphVhpa.....-ctssh..ssRcApslhhhuups..a.hllDLssuplsusphh	................................HPLssLostEI..pp....sst.llp........sut.................hts........s.....h........pFttlsLtEPsKttlh...sa................stssts........ssR..pA......l....l..h..h...s.....t.p........hcslV-..L..ssstl.p.p..h............................................................	0	103	248	379
+1675	PF02728	Cu_amine_oxidN3		Copper amine oxidase, N3 domain	Bateman A, Finn RD	anon	Prosite	Domain	This domain is the second or third structural domain in copper amine oxidases, it is known as the N3 domain. Its function is uncertain. The catalytic domain can be found in Pfam:PF01179. Copper amine oxidases are a ubiquitous and novel group of quinoenzymes that catalyse the oxidative deamination of primary amines to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. The enzymes are dimers of identical 70-90 kDa subunits, each of which contains a single copper ion and a covalently bound cofactor formed by the post-translational modification of a tyrosine side chain to 2,4,5-trihydroxyphenylalanine quinone (TPQ).	20.60	20.60	20.60	20.70	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.13	0.72	-3.96	17	943	2012-10-02 11:54:05	2003-04-07 12:59:11	11	20	497	180	473	884	97	100.70	23	14.32	CHANGED	sslhhcEhspsppllh..p.Ptatcslpp+G..tp.hspVhstPhosGaautts....ucRlh+shsahppsss....shas+Pl-slplllDhcshcVlchp-pt.hhsls	....................................lhh--atplppllp..ss.spatts.l..ccp..G...ls..s..hp.pVhssPh.s............s..........G..........h....hstps......spRlh.pslhahcssss........Nhau+Pl-.lsslV..D.hpptcllcl.c.t..hhsh.................	0	93	229	354
+1676	PF02298	Cu_bind_like		Plastocyanin-like domain	Mian N, Bateman A	anon	Pfam-B_398 (release 5.2)	Domain	This family represents a domain found in flowering plants related to the copper binding protein plastocyanin. Some members of this family (eg  Swiss:P93328) may not bind copper due to the lack of key residues.	20.80	20.80	20.90	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.14	0.72	-4.19	26	1166	2012-10-02 17:41:00	2003-04-07 12:59:11	12	16	93	17	688	1154	2	82.90	31	43.81	CHANGED	Wshsh......YspWAsu+pFplGDsLlFpYssphHsVhcVs.ctsYcsCpssp.shpsas.............sGssplsLsp.GhpYFICuhs..GHCp..tGh	..................................sYssWu.ps..p.p.F.p..lG.DsL............l.F.pY.......s......s.....s...........a....s..Vh.pVs....cssYcsCssss.....sl..t.s.h.s............................sG..s..s..t.l....s...L....s..p...s.G.tt.Y.F.I.suhs.....uHCptG............................	0	76	388	550
+1677	PF03263	Cucumo_2B		Cucumovirus protein 2B	Mifsud W	anon	Pfam-B_4373 (release 6.5)	Family	This protein may be a viral movement protein.	20.90	20.90	41.70	40.80	20.60	18.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.55	0.72	-3.74	7	122	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	9	6	0	124	0	104.60	70	96.29	CHANGED	tuuhosl-LpLA+lVEtK+pRRRSH+pNRRtRGaKSPSERARSpLR....LFphLPFatsDss-.hhshh+c.shs-LspsEss.....s.p.tshDDTDWFAGNEW.sEGSF	......t.GAhTNVELQLARMVEsKRQRRRSHKpNRRERGHKSPSERARSNLR...........LFRFLPFYQVDGSE.Lh...-hh+HssVsELsESEAsp.h..ut-DHDFDDTDWFAGNEW.AEGuF...	0	0	0	0
+1678	PF00760	Cucumo_coat		Cucumovirus coat protein	Bateman A	anon	Pfam-B_867 (release 2.1)	Domain	\N	25.00	25.00	49.30	43.20	18.60	16.70	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.13	0.70	-5.38	4	531	2012-10-04 01:49:40	2003-04-07 12:59:11	13	2	37	6	0	462	0	188.50	85	95.29	CHANGED	sstpRRPRRGpRS....sssutDtsLRALTQQlsRLsphhAuutPTLsHPTFVuSc+C+sGYTaTSlsl+Ps+hEKsp.FGpRL.LPssVoEYsKKhVSplQlRlNP.PKFDSTVWVTlRKlPtoosLostul.thFsDGhSsVLlYQassoGlQsNNKllaDLSshtA-IGDMpKYAllVYSKDDsLEsDElVlHVDlEHQRIPouphL	.............sRRRRPRRGSRS....AsSSADAsFRVLSQQLSRLNKTLAAGRPTINHPTFVGSERCKPGYTFTSITLKPP...KID+GSYYG...KRLLLPDSVTEaDKKLVS.RIQIRVNPLPKFDSTVWVTVRKVPASSDLSVAAISAMFADGASPVLVYQYAASGVQANNKLLYDLSuMRADIGDMRKYAVLVYSKDDALETDELVLHVDIEHQRIPTSGV.L.....	0	0	0	0
+1679	PF02376	CUT		CUT domain	Mian N, Bateman A	anon	Pfam-B_770 (release 5.2)	Domain	The CUT domain is a DNA-binding motif which can bind independently or in cooperation with the homeodomain, often found downstream of the CUT domain. Multiple copies of the CUT domain can exist in one protein (eg Swiss:P10180).	22.50	22.50	22.50	22.80	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.78	0.72	-4.18	26	1069	2009-01-15 18:05:59	2003-04-07 12:59:11	10	15	90	11	655	873	0	84.90	35	19.88	CHANGED	sphssspplsTtcIscclcpcL+...................ctsIuQslFAchlLs...+SQGoLS-..LLp............cP.......KPWsphp.pG+psap+MppaLs.s..psp+thhhh...ppp	.................t......pplsTtcIspcl+.ppLp...................+tsI..sQtlFuchlL..s...hS.Q.......GolS-..lLp.........................cP..............KPWs+Lp..pG+EsFh+MppaLptsps.+..hh....ph...........................................	0	96	146	428
+1680	PF00888	Cullin		Cullin family	Bateman A	anon	Pfam-B_1149 (release 3.0)	Family	\N	23.00	23.00	23.00	23.20	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	588	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.84	0.70	-5.98	47	2251	2009-09-12 05:56:55	2003-04-07 12:59:11	17	46	329	30	1484	2160	44	484.10	20	65.66	CHANGED	Wstlp.ss.....lp..plh..............t......h..laptlhsh............................................p.hut...lYpthtp....hh.........ppaltt.h.tph.t.....................t...hl..h...t.W..a...h.hhtt.hh.a..hs..p.a.ltpp.........................h.h..apt.l.ht...htt.hh..hh..h.....R..p.....p.....htthhp.hh.h........................t..hY.p.Ft..hlptottaYp..s.thl.p..sh.pYh..s..thppEpppst.........alp.ps.t...lhthhpp.hltth.t.l......tth..hhttpp.pcl..ha.lhphh.tslp....hhthhpphlp..ptuhthhtp.........................................................................................t.ps.....hlpthlthht....hhppsF.t......c.....hhtslppsht.hls.t.....................spssEhluhahD.hL+put....pthsptp...................lcpplsplhhlhcalpsKDlFpcaYpphLA+RLlptpSss..-sEpphlstLKp.............................ttG.paTp+lptMhpDlplSc-lsppFc.phhtpp.t..........................................................shshslplLssshWPh.ssp...............hplPp.....clppthctFppaYppp+ss........R+LpWhhpLupsclphph.ttt...........................................h.hploshQhslLhhFNp...............pcplohc-ltpttplstc..tLpc.tL.pslhpsphhh............p..pspphssssthplNppas	.......................................................................................................................................................................................................................................................................................................................................................................h............h....h.................................................................................s......lat..h.............h..........................th.h..t................................................................hl..h.......Wt..pa....................h.h..t......hh.h...h....s...p......h...h.tp.....................................................................................................................................thhh..apt..h..h................h.....t......h.t.............h......h..............lt...p..................R....s........t............p............h..th..h.t.h...................................................................................ha.....ac..hlt.stt.hat..s..................h.t........h.....ah...........s..th.l..pE...hh.................h.h.........t...................l..t.h.p.hl..............t..h.........................tth.....h...h.....t.........t.........t.......p...........t...............p......l...t....h...a......h...h...t........t.............h.............t.......t........h............h..h.t.ht.....thlh..p.u.thh.t...................................................................................................................................................................h...ltt...h..lp...hh.p.p.h....t.h.....h..t........sFtt...........................................p.......h....t.shp.p...s....h.t...h.ls.t............................................................spssEh..l..........u..ha.......h.D...hl+ts....................tp..p........................................................................................................................hcp.h....h.pp...........hhh.l...h..p.hl.....p.s.....KDlF.paYpp.hL.ucR.L....l......................t.....p..........o.....h................s...............-..............t........Etphl..p.h..L+t..................................t.h.G.....p.h...s.p.p.hptM.hp.....Dh.p.h.S..p.ch..t.p.app....h.htpt.........................................................................................................................thphph.lLsts.......h..W..Ph............................................htlP..............phtph.hp.ap.pa..Y..t...ppss...........................R.+L..pW......phupsplp..hp.h...t.t.t........................................................................................................hph..p.loshQ....hhlLh.h....FNp..................................tp.p..ho.hppltp.....t..s.....t..l.....t.....Ltp.tl...t.l...h...p.tthh.........................t.......................................................................................................................	0	530	800	1185
+1681	PF03091	CutA1		CutA1 divalent ion tolerance protein	Mifsud W	anon	Pfam-B_2307 (release 6.4)	Family	Several gene loci with a possible involvement in cellular tolerance to copper have been identified [1]. One such locus in eubacteria and  archaebacteria, cutA, is thought to be  involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognised structural motifs [2]. This family also contains putative proteins from eukaryotes (human and Drosophila).	22.10	22.10	22.20	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-4.35	13	1667	2012-10-01 21:59:08	2003-04-07 12:59:11	10	8	1551	85	550	1191	568	99.10	39	84.17	CHANGED	hhllhlTsPs.-pAcclA+pllEc+LAACVNllspIcShYhWEGcIpcDsEhhlIlKTpspphspLpccl+phHPYsVPEIluLPlppGspcYLpWlcpslc	..............h.hlVhsTsPsc.ts.ApclAttllp..c+LAACsslls.shpSl...YhW.....c.....G.....+....l.....cp-.t.ElthllKTss..sphpsLhcpl..+phHPYpsPEllslPlsp..GsssYLsWlstsh.p.......................	0	154	313	430
+1682	PF03932	CutC		CutC family	Bateman A	anon	COG3142	Family	Copper transport in Escherichia coli is mediated by the products of at least six genes, cutA, cutB, cutC, cutD, cutE, and cutF. A mutation in one or more of these genes results in an increased copper sensitivity. Members of this family are between 200 and 300 amino acids in length are found in both eukaryotes and bacteria.	21.20	21.20	21.30	21.60	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.36	0.71	-5.06	8	2302	2012-10-03 05:58:16	2003-04-07 12:59:11	9	10	2140	20	426	1510	277	197.20	39	85.23	CHANGED	hllElCl-slsulhsApsuGA-RVELCuuLulGGlTPShGllcsAsc...pusIPlasMIRPRGGDFlYs-pElcsMtpDlcss+chGssGlVlGsLsscGslDhcthcpLltAAp..GLuVTFHRAFDhssD..PtcALEpLIcLGs-RVLTSGtt..ssAl-Gh-pLtsLVsQAusRIpIMuGAGlsApNltcLsptTGlsElHuSuts	.....................................................h.hlElCsts......hpsshpA.t...psGAcRlELC..s..s..h.s...G.GlTPSh...G....llcp.s...hp.......................ph.sl...P.lhshIR.PR.....u...........G..............D......Fs.......Y..s-tEhth.MhcDlphs+c..h...........G............s........s......GlVhGsLss...-.G.............p...........l........Dh.....s.th.cclh.s.......s.u..t..................sh..s....l.....TF.HR.....A.FDh..s......s..s................h...p..A.....lc...p.......L.h....p....h.G...l.s..RlLTS..........Gtt....sss.....p..u..l.sh....l.....pc.L.....l......t...p.....u....s.........u.........p.............I.............Ihs...........Gu.GlpscNlpphh.c.......sG.lpplHsot.s............................................	1	136	238	337
+1683	PF01083	Cutinase		Cutinase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.17	0.71	-4.54	23	1537	2012-10-03 11:45:05	2003-04-07 12:59:11	17	11	503	75	597	1612	26	189.00	24	66.18	CHANGED	ssCscltllFARGosEsush...ussGsshsssLputhGusslul.uVt..YsAshsp........tsosssGssshtshlspssspCPsTplVluGYSQGuplhssAlst..............lsuustspltuVllFGsPps........spsls.......................slssh.suK..shshCssuDslC..usuhshss....Hh..sYss-.h.sspAssFlts+ls	........................................................s..C.sh.hhhA.RGot..-...........s.....s..........s.......h..........s.........h.s.......s....h.h...s.sl......p......p...p.h.....s...........p..s.l...ssh..s..Vs........Ys..Asht.........................t..os.stGs...p.s.h........sstl.....pp.h......s......s..p.....C.P.s..T.....clVLuGY.....SQGAslhstshss...................................................sh.s.s.s..s...s..s..+.l...su..l....sLaGs.Ppp..........sts.hs.................................................................shs..s...h..s..s.+...s....hplCs.s....u..D..sl.C.......ss...................s.............H.....Y...........u..hh.................................................................................................................	0	135	324	513
+1684	PF01473	CW_binding_1		Putative cell wall binding repeat	Bateman A, Mistry J, Russell R	anon	Bateman A	Repeat	These repeats are characterised by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins.  The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls [1]. Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding [2] as well as in the related dextransucrases of Leuconostoc mesenteroides.  Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known.	20.50	9.80	20.50	9.80	20.40	9.70	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.74	0.73	-6.64	0.73	-3.57	213	28133	2009-09-16 13:19:13	2003-04-07 12:59:11	15	543	547	186	1455	18171	72	18.80	40	20.20	CHANGED	suWhp.h..s..ssW.YYh.sssGsM	............sGWhp.......s...upW.YYh..sssGtM........	0	419	1058	1118
+1685	PF04122	CW_binding_2		Putative cell wall binding repeat 2	Kerrison ND, Finn, RD	anon	COG2247	Repeat	This repeat is found in multiple tandem copies in proteins including  amidase enhancers [1] and adhesins [2].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.12	0.72	-3.78	99	3897	2009-01-15 18:05:59	2003-04-07 12:59:11	7	210	151	0	926	3881	25	92.20	26	35.86	CHANGED	pRl.sGss...RY-Tuhp....lupp..........h..........h..sssslhl..s....sG....ps..asD.ALuuuslAup............pssPllLss....ssh...psstshlpsh...........t.pplhll..GGpssls...pp....lhpp	..............................................Rl.uG..ps...Ra-Tuhp....lucp.....................h.t............................t.....sssp.lh.l..s.............sG...........ps......hsD..ALuuuslA.sp..............................t.s.u..PIlLss.......tssls....ssstshl.pph.........................tspplhll..GG..p.sslsppl...t...........................................	0	554	857	897
+1686	PF03638	TCR	CXC;	Tesmin/TSO1-like CXC domain, cysteine-rich domain	Bateman A	anon	Pfam-B_1144 (release 7.0)	Domain	This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin Swiss:Q9Y4I5 [1] and TSO1 Swiss:Q9LE32 [2]. This family is called a CXC domain in [2].	20.30	20.30	21.20	20.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.62	0.72	-4.10	90	900	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	139	0	617	883	19	40.70	48	14.71	CHANGED	ppp+sCsCKKSpCLKhYCECFtsGthCsp..CpC.psCpNptpp	...............pp+sC.sCKKStC...LKhYCECFt...........uu..hhCss...CpC..psCpNp........	0	297	406	520
+1687	PF03128	CXCXC		CXCXC repeat	Bateman A	anon	Pfam-B_252 (release 6.5)	Repeat	This repeat contains the conserved pattern CXCXC where X can be any amino acid.  The repeat is found in up to five copies in Vascular endothelial growth factor C [2]. In the salivary glands of the dipteran Chironomus tentans, a specific messenger ribonucleoprotein (mRNP) particle, the Balbiani ring (BR) granule, can be visualised during its assembly on the gene and during its nucleocytoplasmic transport. This repeat is found over 70 copies in the balbiani ring protein 3 Swiss:Q03376. It is also found in some silk proteins [1].	13.20	13.20	13.20	13.20	13.10	13.10	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.42	0.74	-6.50	0.74	-3.42	116	305	2009-01-15 18:05:59	2003-04-07 12:59:11	9	19	71	0	133	258	0	13.90	43	10.39	CHANGED	sphWscpoCpCtCs	....sppaDcsoCpCsC..	13	46	52	85
+1688	PF02560	Cyanate_lyase		Cyanate lyase C-terminal domain	Mian N, Bateman A	anon	COGs	Domain	Cyanate lyase (also known as cyanase) EC:4.2.1.104 is responsible for the hydrolysis of cyanate, allowing organisms that possess the enzyme to overcome the toxicity of environmental cyanate. This enzyme is composed of two domains, an N-terminal helix-turn-helix and this structurally unique C-terminal domain [2].	25.00	25.00	25.80	32.60	24.80	20.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.45	0.72	-4.44	25	725	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	688	80	229	524	63	73.00	59	47.15	CHANGED	shp.slPoDPhIYRhYElVhVYGsolKplIpEcFGDGIMSAIDFsh-l-+.psPc.GD.RVVlThsGKFLPY+pa	........sh...stlPTDPslYRFYEhlQVYGsTlKALlHE+FGDGIhSAIsFclDVcKlsDPc.G-.RsVITLcGKaLPhKs......	0	59	131	184
+1689	PF04199	Cyclase		Putative cyclase	Bateman A	anon	Pfam-B_1440 (release 7.3)	Family	Proteins in this family are thought to be cyclase enzymes.  They are found in proteins involved in antibiotic synthesis.  However they are also found in organisms that do not make antibiotics pointing to a wider role for these proteins. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form part of the active site.	20.80	20.80	20.80	20.90	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.41	0.71	-4.57	76	2705	2009-09-13 14:05:17	2003-04-07 12:59:11	8	22	1704	5	1053	2458	695	168.90	21	65.07	CHANGED	lhDLohslp..............pt.h........shh............h....................tt.hsh...pt....shsspt.lp.h.ssHsGTHlDu.sH........h................s.................sl-plPlp....hhs.pulllDlsp.................hsst-lptshpt.th...plptu-hVll+T......................Gh.................tphh..sstp.ahsp..........PGlsh-uucaLh.cpGl...pslGhDshuh...........-ts.	.........................................................................hDlo.shp..................t..h........shas...........htht.h............................................tt........tshtspp..lp.h..ssp..s.G..THhDAPhH.........................................................h.tsst.........................................sl-p.l.slct.............hhu.......ulll..Dhsp.....................................ssthl.shpclt..tthtt.th.........pl.pt.u.c.hVll+T..........................................uh.......................................pp...hh...............s...s..tp...hhps................hs.uh....s.......-........ss..caLh....-..p..sl......pslGhDshuh-...s..............................................	0	330	674	904
+1690	PF02984	Cyclin_C	cyclin_C; 	Cyclin, C-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.	21.20	21.20	21.20	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.72	0.71	-4.17	240	3032	2012-10-03 00:42:12	2003-04-07 12:59:11	14	43	449	158	1706	2961	42	116.40	20	28.12	CHANGED	PTshsFLcR....h.t+...........s...sph..................s....p........hcplupalhE......Lolh-ap............hlpahPShlAAuA..lhlupph......Lt.....t.............WspsLptao.uY...stspLtsssphlh....phhh...pss.....tsph.p..ulhcKYsppchtp.........lu.hhss.	..............................................................................ssshpFLpp........h..h+................h.........sph...........................s..p..........hcphupahhE........................lol..h-hp..................hlp.a.PS.hlAAuu..lhhAtph.......lp....t...................................Ws.p..p..l..t..t.ho..sh.................s.p...p...l..t......s....s.hp...hlh..phh............p.....................thhp+ht...............h.......................................................................	1	471	819	1258
+1691	PF03784	Cyclotide		Cyclotide family	Bateman A	anon	[1]	Domain	This family contains a set of cyclic peptides with a variety of activities. The structure consists of a distorted triple-stranded beta-sheet and a cysteine-knot arrangement of the disulfide bonds [2]. Cyclotides can be separated into two subfamilies, namely bracelet and moebius. The bracelet cyclotide subfamily tends to contain a larger number of positively charged residues and has a bracelet-like circularisation of the backbone [2]. The moebius cyclotide subfamily contains a backbone twist due to a cis-Pro peptide bond and may conceptually be regarded as a molecular Moebius strip [2].	20.30	20.30	20.50	20.50	17.20	19.80	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.22	0.72	-4.07	30	259	2009-09-11 23:07:15	2003-04-07 12:59:11	8	4	30	33	0	274	0	29.80	57	44.52	CHANGED	G..lP.CGESCsalP.C...tssG.CSCcs+...VCYhN	.......GlP.CGEoCVhhP.C...sshG.CSCpsp...VCY+N..	0	0	0	0
+1692	PF00548	Peptidase_C3	Cys-protease-3C; 	3C cysteine protease (picornain 3C)	Bateman A	anon	SCOP	Family	Picornaviral proteins are expressed as a single polyprotein which is cleaved by the viral 3C cysteine protease.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.45	20	4118	2012-10-02 13:45:52	2003-04-07 12:59:11	15	54	450	68	1	3087	3	135.60	48	11.78	CHANGED	GPsh-F....uhuhh+pNlhslsT...........spGcFTtL..GlaDplhV.....lPpH..upsscsIhlsGppsplhD....uhpL.lcppGssLElTllpL..cR...NEKF.RDIRpals...pphpcts-ssLslNosphsphhlsVGpVsthGhl.sLuGssTpRsLhYsaPT+sGpCGGVlhs....sGKllGlHlG.GNG	...........................................................................................................................................................P..-h..thhht.Nh.h.sph...........tp.s...h.h.hh...G..lhsphhl.....lPpH........ut.h...plhh.....p..t...t...hph.-.........thtl...stpsh......h.....-lsllpL..cp...s..p+F.RDIptals............pp.s.t..h..sss..shhl.......s.s....pc.hss..hh....l..s.l.us.....ls......G...h...l......s...hs......G.......p............o..t.+...h...hhYp..a..s.T+....A.GQCGGVl.h.u...........s.GKllGIH.lG.GNG...........	0	0	0	1
+1693	PF00007	Cys_knot		Cystine-knot domain	Sonnhammer ELL	anon	Published_alignment enriched with PDOC00234 members.	Domain	The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins.  It is believed to be involved in disulfide-linked dimerisation.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.85	0.72	-11.43	0.72	-3.95	24	1416	2012-10-02 16:54:34	2003-04-07 12:59:11	17	22	417	7	416	1343	0	92.30	29	44.70	CHANGED	t.hCp.hN...hTlplE+csCshClslpTTICsGaChTh-...sh.ssh..h.QplCsac-hpYcohclPsCPsGssPhhoYPVAhSCcCs..tCstssoDCsh.thpsshC	.......................h...C..hp.......hsht.h..ch...p..t...Cs.s..h.shp.sshC.GhChp.........................s....s.....t................p..sC..shtchph.psshl.......sCP...s.....G......s.s...s...h...h..o...ash...sh...oCpCs...tCpts.ss.h...........................	0	44	77	214
+1694	PF01053	Cys_Met_Meta_PP		Cys/Met metabolism PLP-dependent enzyme	Finn RD, Bateman A	anon	Pfam-B_366 (release 3.0)	Domain	This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase,  O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.10	0.70	-6.18	30	12248	2012-10-02 18:26:03	2003-04-07 12:59:11	15	41	4308	161	3561	25261	14126	368.30	34	93.53	CHANGED	sThtlHuGpp.c...spuAlssPIYtoooatas........tsscpsG.a.YoRpGNPTpssLEcplAtLEuu..stulAhuSGhAAl.sslhsLlcs.GDc.....llsssslYGG.....Taphhcpshs+.hGlpssaVDs....schsslcpAlps..sTKhlalETPoNPhhclsDIttluclA+cp..s..llllVDNTFsoP.hlppPLcLG..ADlVlHSATKYlsGHuDVluGlllsps.tclspchthht........................................sshGusluPaDuaLlhRGl+TLsLRhcppspNAhplAcaLcpc....P....pVcpVhYPGLsoHPpH-lA++QhpGhuu..hlSFclcus............tupchlcsl+LhohAtSLGusESLlptPAsMTHuslstEpRtstGls-sLlRlSVGlE-h-DLlsDLcQALc	.............................................................................................................................Thhl+uG..p.c.............tt.su.hssPI..a.o................ooa.h.....as.........................................................................h..........h..........t..........p........t..............t.......G.....h...............Y.o...R...h...s.......N................P...T....p...p...s...l....E.....p....t....l..A.t.......L..........E..........G.....G..............t.....s...........u..........h.........s....h...u........S........G.................h.....A.......A....l.............h......s......l.....h.....s.......l.........h.......p....s.....G..D....c.......................l...l........s........s........s........s.....l.........Y......G...G............................T.h...p...l.......h........s.......p.......h......h........t.......+.......h......G...........l......p.........s.....s.......a...l.....D..s.......................s...s......h......p.......s......l........p.......t.....s.....l....p........s............p......T.............K.............h.....l............a.....l....E.....o....P.......u....N....P.....h....h............p....l...s....D...l...t...t....l....u....p.....l.....A.......+...pt..........u...........h........h.........l........l...........V.........D............N.......T............a.........s..........o...............P......h.......h............p..........p.........P.......l......c........h...........G..........A......D.....l.......V..l..H..S..u....T..K..........Y..l........s.G.....H..u..D.s....l.......u..G....s.l.l...s....s........s...................p...ht....p...p..h..t..h..h..t....................................................................p.s.h.G....s....s....l..u...P...h...s..u...a....L......l..l..+.G...L....c....T....L...s....l...R....hc...p.....p...s....p.N..A.....h.p.l.A....c..a.L...ps..+.....................P.........................tV.p...p..V....hY...P........u......L.........................s.......p..............t.....a......p.....l...t..p............+.......................h...........p..............G................t.........u.......u...........l..lSFplcss.....................ttstphl....ssL....c....l.h.s....hutS.lGsscS.L.l....h..a.....P.....u...s.....h....T..H......s....p....l.....s...t..c.....t.....p.....t...t..t..G.........l..ss.sL..lRlSlG.lEc.s-.DLlsDLcpAL.t.........................................................................................................................................................................................................	0	1060	2191	2996
+1695	PF00839	Cys_rich_FGFR	cys_rich_FGFR; 	Cysteine rich repeat	Bateman A	anon	Pfam-B_297 (release 3.0)	Family	This cysteine rich repeat contains four cysteines.  It is found in multiple copies in a protein that binds to fibroblast growth factors [1]. The repeat is also found in MG160 and E-selectin ligand (ESL-1).	20.60	20.60	20.60	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.16	0.72	-4.04	85	1785	2009-01-15 18:05:59	2003-04-07 12:59:11	12	15	137	0	1097	1610	20	58.80	24	71.91	CHANGED	pcCc.ptlhph..pp..spDh+.....lsstLhpsCcp-l...pc..aC........sp............ttspupllpCLppphpp.tp	...........................cCc.ptlhph...pt....spD.h+..............lsstLhpuCc....s-l...pc.....hC...........ss..................................ttspGpllpCLhpphtp..t......................	0	339	467	794
+1696	PF00031	Cystatin	cystatin; 	Cystatin domain	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	Very diverse family.  Attempts to define separate sub-families failed.  Typically, either the N-terminal or C-terminal end is very divergent.  But splitting into two domains would make very short families. All members except Swiss:Q03196 and Swiss:Q10993 are found. Pfam:PF00666 are related to this family but have not been included.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.92	0.72	-3.86	43	2054	2012-10-01 19:28:07	2003-04-07 12:59:11	16	20	367	81	813	2132	5	88.60	17	54.95	CHANGED	Gulpssss..sssclpcslchAlscaNpps..tsthhchhclhcsppQVVuGh..pYhlchplscssC........ptpshpsCshh....ppphthsshpshptst	.....................................................hps...sssplpph...sphul..p.p....hN.........p.....ps........................s........h..........h....hp.h.h.c...l...h...c......u......p...p.....Q..l..V......u...Gh......pYh..lp..lclt.cs.p.s............ptp.hp....s.p.h...............pth..................................................	0	158	262	454
+1697	PF01578	Cytochrom_C_asm	CytC_asm; 	Cytochrome C assembly protein	Bashton M, Bateman A	anon	Pfam-B_114 (release 4.1) Pfam-B_8014 (Release 8.0)	Family	This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium[3],  CcmC from E. coli and Paracoccus denitrificans [2,1] and orf240 from wheat mitochondria [4].  The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an  ABC (ATP binding cassette) transporter complex. It is also proposed  that this transporter is necessary for transport of some component  needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif [3], orf240 also contains a putative heme-binding motif and is a proposed  ABC transporter with c-type heme as its proposed substrate [4]. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither [1].	21.10	21.10	21.10	21.20	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.60	0.70	-4.79	39	8917	2012-10-03 10:28:09	2003-04-07 12:59:11	15	16	4477	0	1718	6398	4666	196.50	21	51.54	CHANGED	huslhtulhhhshshshhhhlh.t...p....thhuslshsssh...........................lhhuhhhh.......................l.....tssslssslps.hLhhHlshhhhoYushhlushhulhhL...........................................................................ht.htthcphshphhhlGashLTlullsGuhWA..p.sWGsaWsWDP+pshuLlsWllasuhL+sth..pc.shtuctsulluhlGFhllhlshauVphh..slc	............................................................................................................................t..sh.h.h.hs.h.h.h..shh.....hhh......................................p.........t..........................th...........h.s.t..h.h....h.h...sh........................................................................................................................h.s.h.uhhhh.................................................................hh.............h..t..s..t.s.l..s.s..h..L.p....s......h..l.h.hHl..sh..hh..hu.Y...s...s...hh...ls.h.h.h.ulhhL..........................................................................................................................................................................................................t...h..........h..tt..ht...p..h..sh.t.h...s...hG...hh.h..ho...l.u.l.lhG.u...h..Wu........p.sW....G...s..a..W.h..W..D.s+.ts.hu..hl....s.ah..las.u..h..la.hhh........pp...sh..t..t..p..h..s...s....h..h..s..l..h.u.h.h.h.hh.l.shahVp.........................................................................................................................	0	525	1095	1442
+1698	PF02224	Cytidylate_kin		Cytidylate kinase	Bateman A	anon	Pfam-B_1582 (release 5.2)	Family	Cytidylate kinase EC:2.7.4.14 catalyses the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.	20.40	20.40	20.40	20.40	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.69	0.71	-4.79	14	4159	2012-10-05 12:31:08	2003-04-07 12:59:11	13	26	4102	23	894	2951	2326	155.70	40	63.80	CHANGED	hphhhphplphh.p.st....shhsGpDlosp.IpopEVuptsStlushPtVRshhschQ+phuc..ssslVhEGRDlGTVVhPcAplKIFLsASsEhRApRRhpphstpu..s.sh-pLlt-ltcRDphDppRssuPLhhAtDAlhlDTSsLolp-Vl-cllp	........................................hs....phplph.....p..t..s..t..p....Vhl....s.G..c..DV.op.t..IRsp-VustsS.tVA.u.hPtVRctLlptQRp....h.....u............p..........t.........s..........G..........l.....V.hDGRDIGTVVh.P-.........A...p....lK....IFLsASsEpRAcRRhpph..t........p.....+.........G......h......s...s.........s...h.........-....p..l...hp-.......I.pcRD..pp.D..p.sR.....p.....lu.....P.L.....c........As.....D......A......l.....h.lDoTsl....oI-pVlpplh.t....................................................	0	314	596	761
+1699	PF01265	Cyto_heme_lyase		Cytochrome c/c1 heme lyase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.40	20.40	22.40	21.30	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.16	0.70	-4.80	46	463	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	263	0	351	449	4	246.90	36	87.58	CHANGED	M.................s..t...............................s...spCPlscpspp......................................................stCPspt...............................................tphss..sshhss.spp.ssspshsLsscREhSSIPRs........................................t.usus........WlYPStpQFaNAMlRKGa..t.pp.....tsshcslVslHNtlNEpAWpcIlcWE..tha..................................scpCs.sP+LhpFtGcsc-...hoP+Aphpph.hG........hphPFDRHDWhVsRC.G..........+-VcYVIDaYs...Gssps..........p.....s......haLDVRPA.Lsohpu...sh-Rhh+h	.......................................................................s.....................................................tCPhptt......................................................................stC.Phtt..............................................p.p.l..sP......ssh.s.s.sp..p....s.ssQs..hs.LsscRphSoIP+u.........................................................s..ssss.......W.YPS.Q.Fa..NAMlRKGa.t.t...tphs....tcshcslltlHNtlNEpAWpEIlcWE..t..ha...........................................................sppss..sP+LhpFtG+sp-...hSP+ARhpph..hG.....................................hphPFDRHDWhVsRC..G...............................ccV.RYVIDaYsGssst.........................p.....s.......shhLDVRPA.lsohpush-Rhhh.h....................................	1	120	196	293
+1700	PF02322	Cyto_ox_2		Cytochrome oxidase subunit II	Bashton M, Bateman A	anon	Pfam-B_997 (release 5.2)	Family	This Family consists of cytochrome bd type terminal oxidases that catalyses Quinol dependent, Na+ independent oxygen uptake [2].  Members of this family are integral membrane proteins andi  contain a protohaem IX centre B558. One member of the family  Swiss:O05192 is implicated in having an important role in micro-aerobic nitrogen fixation in the enteric bacterium Klebsiella  pneumoniae [1].	28.10	28.10	28.70	28.50	27.50	28.00	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.19	0.70	-5.27	134	4601	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	3012	0	866	2836	242	331.80	32	94.78	CHANGED	sLtllWahllulhlhhYslhDGFDhGlGhLh.sh....hsc...........-p-RchhlNolGPhWDGNEsWLlhuGGulFAAFPhsYAslhouhYlslhlhLhuLIhRuVuFEaRtK.st.s.ph+.....phWDhshhhGShlsshhhGlslGs.llpG...lshs.............................................ttas....Gs..............h.hsh...lsP.........FullsGlsslshhshhGusaLhhKTcG....p.lpp+Apphuthhshsh.hshhhhss.............................hhshh.tsthhtpah.shshhhhh.sslsllsslhshhhh...thp+............pth..uFhsoulsh.hhshhslshuhaP....hllPus...........sLTlasAuuuthoLphhhhsshlhlPllLsYssasYhlF+	......................LphlWalllulllhsahlhDGFDhGlGhLh....h.....lu+..........................s-p..E...R...+...l...hl..N.....ol.....uPhWD.....GNpVWLlhuGGAlFAAFPhsYAs.hFSuhYlshhl.lLhuLhh.RsVuF-aRsK..h...ssc.a+.....phWDhuhh.lGShl.ss....hlhGl...AhGs.llpG....lshs............................h.....................thtasGs......................h.hpL..........LsP...............Fu.l..l.sGls...s...lshh...hhhG....usa..Lt..hKT..pG.....t.lp.pR..u....pphuphhullh....hlh.h.h.lsu.....................................hhssh.....sss.h.hp.p.a.........h..p.h.P......h.h.h.hh...ss.l..ul.ls..hlhs.hhhh....thp+.....................ssh......uFlhsslth.hhshhshuluhaP....hlhPus................sLTlas......AsSot.hTLplMhhss.ll.h.l.PllLsYshWsYahh...........................................	0	238	510	701
+1701	PF00283	Cytochrom_B559	cytochr_b559; 	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits	Finn RD	anon	Prosite	Family	\N	29.50	29.50	30.70	30.30	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-6.92	0.72	-4.66	8	2001	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	993	42	112	639	147	28.50	55	47.05	CHANGED	sscshoYPIFTVRWLAIHulAIPolFFlG	..........hphshs..IholRahslHulslPolFhhG...	0	28	71	99
+1702	PF00284	Cytochrom_B559a	cytochr_b559a; 	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit	Finn RD	anon	Prosite	Family	This family is the lumenal portion of cytochrome b559 alpha chain, matches to this family should be accompanied by a match to the Pfam:PF00283 family also. The Prosite pattern pattern matches the transmembrane region of the cytochrome b559 alpha and beta subunits.	25.00	25.00	28.20	27.70	22.80	22.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.93	0.72	-4.44	25	1065	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	972	19	62	465	127	39.70	82	49.73	CHANGED	LAYDVFGTPRPNEYFTpsRQclPlloDRFsAhpQl-phsc	...........LAYDVFGSPRPNEYF.TESRQGIPLITGRFDuLEQLDEFS.p...	0	14	39	56
+1703	PF02335	Cytochrom_C552	cytochr_c552; 	Cytochrome c552	Mian N, Bateman A	anon	Pfam-B_19175 (release 5.2)	Family	Cytochrome c552 (cytochrome c nitrite reductase) is a crucial enzyme  in the nitrogen cycle catalysing the reduction of nitrite to ammonia. The crystal structure of cytochrome c552 reveals it to be a dimer, with with 10 close-packed type c haem groups.	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.24	0.70	-12.83	0.70	-5.79	38	1136	2012-10-01 23:37:15	2003-04-07 12:59:11	10	12	966	82	171	735	44	413.10	48	88.71	CHANGED	s.tpau........+taPpQYcoW+cTsE..ss.........s................htDtLcccPtLslLWuGYuFu+DYscPRGHhYslpD.hpohRssss...........stsuuChoCKoPssPcLhcchG-........sYFsspascstscIs.......ps.............luCsDCH-sp.shp.......L+loRP.tlt+AlcslGh.......................c.hc...to+p-hRohVCAQCHVEYYFptc.............................................sptVpFPWspGh......olEsh.pYYDphs..........FtDWTHulSts.MLKAQHP-aEhas.pGlHupsGVoCsDCHMPhsp.tsupKhoDH+.lt.SPL.sshp...coCtsCHp.poc-tL+spVtshps+shphth+AtptlspAth-h................ctAh.cAGAspcchc.....puhphhR+AQWRhDashAppusuFHAPpEulRlLusul-cAscAcspLtplLAptGlps........PshsshphAphshshshc+h.hct..pp.lcs..hsp................................t+	.........................................................ts..Epau.paPcQYtSWpsTu-..ps...........................................thctLt..ccPpLlILWAG.YsFS+DYNcPRGHhaAlsDlccTLRTGu.Phss.pcG...................................s.P.hACWoCKSPDVs.RL....I.pc.G-................................cuY.ap..u.KWuchG..sE.Is........Ns.......................................lGCADCHsss.o..c.......LploRP.hshcAhculG+............................s..hc....cAs..R.-.pohVCuQCHVEYYFcuc...........................................................sKsV.pF.PWD..cGh.......................cVEshE...p.YYDclu..................FuDWTp.....sLSKsPML.KAQHP..EYEh.W...o....sG.......l..H..G..c....N....s...VoClDCHMPpVp....tpG.K....hY......TDH.+..Is......sP..h....cs...hs......pTC..t..sCH......s....Q..s..c.st...Lp..p.hVt-+ppplp-hph+s...EcpLV+AHhEA..................................................+tAh.....D.A.G.....A.T.....-.tEMK......slhptIR+AQWRWDhuhASHGht.....hHAPcEuhRhLusAhDcAtcARsKLscl..LApp.Glsc....tl.h..P...D.I.STtpKApthlGl.sh.pp.hpAtK..ppFlcsl.lPp.W.cpAp..ss..............................................	0	57	111	146
+1704	PF03188	Cytochrom_B561	Cytochrome_B561; 	Eukaryotic cytochrome b561	Mifsud W	anon	Pfam-B_2927 (release 6.5) & Pfam-B_7165 (Release 8.0)	Family	Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.96	0.71	-4.34	48	1285	2012-10-03 10:28:09	2003-04-07 12:59:11	11	38	290	0	837	1341	24	131.30	21	41.09	CHANGED	hHPllMslGalhLhG..........EAlLsa+.s...hh.hs+pspKhlHhsLphlAhhhullGlhuhap.+stp..........t...h.sphhSLHSWlGlsslhLaslQhlsGhssahh....PthstthRshhhPh..HshhGlssalLulsoshhGh.pphhFt	...................................................Hshhhhhuh.h.hhh..s...............................u.l.lh...h+.....h......................h..................s....c.........h....hh......h.......lH..hhlp.h..l.uh..l..l.ul..s..G..hsh.s.h...t.h.c.s.t.............t.....h...sp..h.h..........o....h......HuhlGlssh.h.L.h.h.l....Qhl......h.............G.hh...h..h....hh.................P...t...h...s...t...p.......h.....R...t..h..h..h..h..........HhhhGh..shhl.luls.shhhGh.......t...............................................	0	230	447	659
+1705	PF00032	Cytochrom_B_C	cytochrome_b_C; 	Cytochrome b(C-terminal)/b6/petD	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	18.90	20.70	19.30	20.60	18.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.54	0.72	-3.79	114	70433	2009-09-12 14:19:01	2003-04-07 12:59:11	12	20	28713	95	599	68332	2102	89.80	73	27.89	CHANGED	.ANPhhTPsHItPEWYFL.hYAILRS..................IP.....sKLsGVluhhhSlllLhhlPh....hp....puphpohp.ap.shh.phhaah.....FlssallLsalGupPs-......Pah..h.luplhol.h...YF	........................PANPL.s.TP.PHI.KPEWYFLFAYAILRS...............................................IP...............NK...L...G.G.VLAL....l....hS.I...L...l.Lh.llPh...LH.............T.S.K...Q.R.....u.h.....t.....F...R....Plo.....QhL.....FWh.....Ll.Ash.hlLT.WlGu..PV.Ep...........Pa.l.hIGQlASh.h...YF............................................	0	158	359	481
+1706	PF00033	Cytochrom_B_N	cytochrome_b_N; 	Cytochrome b(N-terminal)/b6/petB	Sonnhammer ELL	anon	Prosite	Domain	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.39	0.71	-4.94	92	8451	2012-10-03 10:28:09	2003-04-07 12:59:11	14	32	3033	2	1429	91159	3309	164.10	19	83.40	CHANGED	httashhh+...........lh.HW..hhulhhlhhh.h...sGhhhh................................................................hhh..hshtthhhtlHhhhGhhhhhlhlh+lhhthhp........................................h.t.t.ssttttshhtphshhhlhhh.hhhhsloGhhh....................................h..hh..stshhphh.....thlH.thhshllh.shlhlHlhhshhtphh....shlptMhsG	.................................................hash..phhHW......lhul.shl.h.hh...h......oGhhhh....................................................................ths.t...h.s.h..h.h..h...h.p.......l..HhssG.hh....h....h...l.s..hh..h+l.hhthht..................................................................................................................................................h..h......h.p.h.ht..p...h.h.a.h.h.hhhh..hhhh...l.o.Ghhh................................................h...........h...h..................h..h.....thh.............t.h.H...h.h.s.h..h.hh.hhl.hhHhh..h.Al.hhph.........sslttMh..........................................................................................	0	342	765	1112
+1707	PF00034	Cytochrom_C	cytochrome_c; 	Cytochrome c	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	The Pfam entry does not include all Prosite members.  The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, Pfam:PF06181, has now been merged into this family.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.47	0.72	-3.15	237	12531	2012-10-03 10:02:11	2003-04-07 12:59:11	16	182	3088	283	4329	18590	7463	94.00	18	36.97	CHANGED	hspG...pplh.p.t.......pCssCH.utssps...........................................Pslsshstthhhpthtthhttt..h...........thh.tth...shh....................................loc.p-htslssal.php	.........................................pG.ttlh..t..t...............sCsu.CH...us...s.s..t.u.st.h................................................................................hPsL..t...s..h...s.....s....p.....h......h...h.....t.....t......h......t..t.........h...h..s...s...s.....t..t.......h..........................................thh.....t..t.....h..............................................................................loc.p-..hpsls....uYlts..t........................................................................................................	0	1149	2550	3504
+1708	PF02167	Cytochrom_C1	Cytochrome_C1; 	Cytochrome C1 family	Mian N, Bateman A	anon	IPR002326	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.64	0.70	-4.69	124	1691	2012-10-03 10:02:11	2003-04-07 12:59:11	10	8	1421	83	579	1376	2156	190.90	30	70.78	CHANGED	a.....sasG.hspaDpsuLQRGhpVYppVCuuCHShphltaRpLsc.............luho.......-sp..........l+shAtp...p.h.s....sGp........Rsup.uDhhssshsscpAtthhssGAhPPDLSLlu+ARt....................sGs-YlaoLLpGY........hc.s........................Ps......................tsstahNshF.......................................su..luMs.sL.h-t....l.....................................................pasD.Go.........ssoh-QhucDVssFLhWsAEPphppRKphGhhVllFL.slhsslhYhhp+ph...Wpsl	...........................................shhDps.ulpRGhplahph.C.uCHSh.phhtapplhs.............lshs..tpp..................................h+t.hh................................pup...........phuDhh.sshssp..pAsphh..GAhPPDLSlls+uR..........................GsDalashL..pua.........p.s......................................ss................t.hh..h.N.hF.......................................ss.....luMstsL...p.....s..........................................................phts..Gs.............stphsph..scD.lssFLtasuEP...tt.tpR.+phGhhlhhaL..s.l.hhh..ls..hhh..K+phWpp...........................................	2	173	330	465
+1709	PF01322	Cytochrom_C_2	Cytochrome_C_2; 	Cytochrome C'	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.82	0.71	-3.57	95	629	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	492	53	234	648	813	114.10	23	73.21	CHANGED	pc...s.lchRQuhh.ph.hutshu.sluuM.s+GchsaDsststtsAsslssluphshst..F.stGocsus.....TcApPpIW.pchscFppphsphppsuspLsssA.tsG..Dh.sul+sAhsslGts.CKuCH-saR	............................................................................t...lp.Rpshhp..ht.ph.t.thssh.hc.G..p..sa-stt..htttut..tls..th.u.ph........ph..F...tsspts...........scAhstlW..p..c..hscFpt.ttpphpsssspLss.uA....psu...ch...s....slpsuhsp.huts.CcuCHcsaR...............	0	54	144	186
+1710	PF02085	Cytochrom_CIII	Cytochrome_CIII; 	Class III cytochrome C family	Mian N, Bateman A	anon	IPR002322	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.92	0.72	-11.89	0.72	-3.92	24	410	2012-10-01 23:37:15	2003-04-07 12:59:11	11	26	147	90	206	698	264	94.70	21	46.57	CHANGED	P.....hshcsPssst.........pptsVsFsHpsHt.ps.....sCpsCHHt........tsttphssCss..CHss.t........scps.tsh...hpAhHspps..........oClGCHpphttpt.t.............ps.suC.stCH	................................hht........................tsl.FsH..t..hHs.ph..t..........sCpsCH..+s.......................sstssh.....t..s.....Css........CHsth...........................tptt..h.th.........ht..u..h..Ht..............................pCh.s.CHtp.t................................C....CH................................	0	92	172	198
+1711	PF03264	Cytochrom_NNT	Cytochrome_NNT; 	NapC/NirT cytochrome c family, N-terminal region	Mifsud W	anon	Pfam-B_1404 (release 6.5)	Family	Within the NapC/NirT family of cytochrome c proteins, some members, such as NapC Swiss:P33932 and NirT Swiss:P24038, bind four haem groups, while others, such as TorC Swiss:P33226, bind five haems. This family aligns the common N-terminal region that contains four haem-binding C-X(2)-CH motifs.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.29	0.71	-12.03	0.71	-4.83	111	2644	2012-10-01 23:37:15	2003-04-07 12:59:11	9	24	1304	8	392	1397	89	166.30	41	59.71	CHANGED	ps...stphslshll...llGhlsGllhauuhpsshchTsopcFC.lSCHp.Mpss.apEappolHapNpsG.VRAs.CsDCHVP+..chh.sKhhpKhp.Au+-latch.hGplsT.EKF-.t+RhphApctWtch+sssStpCRsCHshp.tMch..spQ....ptpApptHpps..................h....tpsp..TCIDCHKG.....I.AH.....phP.ch	................................h...+htlhsll..llG..h.l..sG..l..h..h..h.ssh..p....su.hc.h.T.....sopc.FC.lS.CH...p..Mps.....s.....YpEY.p.......p.......o.l.....Ha......p...........N.t.......pG....lRAp...CsDCH..l.........P..+............-hs...shhh.pKlp....ASK-lYtph..hs.pIDT........P-K..FE......s.+Rhp.....hAcp.pW....p.chK....sN.sS...t...pCR..s..CHsa-....tMDh...spQ............pspA....s.+..........aptA.......................................h...........ccsp.....oCID..CH.KG..IAHpLP-.........................................	0	120	230	327
+1712	PF01801	Cytomega_gL	Cytomegalo_gL; 	Cytomegalovirus glycoprotein L 	Bashton M, Bateman A	anon	Pfam-B_1420 (release 4.2)	Family	Glycoprotein L from cytomegalovirus serves a chaperone for the correct folding and surface expression of glycoprotein H  (gH) [2]. Glycoprotein L is a member of the heterotrimeric gCIII complex of  glycoprotein which also includes gH and gO and has an essential  role in viral fusion [1].	25.00	25.00	144.60	144.50	20.70	19.80	hmmbuild  --amino -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.38	0.70	-4.85	7	80	2009-09-12 02:32:10	2003-04-07 12:59:11	11	1	37	0	0	58	0	204.20	59	82.04	CHANGED	hpscChcshhpChpu......p..ShhpPlhs....cusl......hSpLIRapp...........ptphhss..lhls--FL-plhLLaNNssQLRsLLTLl+.S-sussWhsahpGYspC.tsssslaTCV--lCppYsLp+LpYspslFsEsVlGFElssP........shulLlhlcNptT+ss+lVRlssso......loLFDulYNhl+pFhhch.ulshsLlpcLcpYpspLPs.a+puc..slhtRsh	.ss.sECsELTRRCLhGEla.pusch-SWL+PLVN.VTsR....DGPL.......SQLIRYRPl..........TsE.AAso..VLLDDuFLDTLALLYNNPDQLRALLTLLu.SDTAPRWMTlMRGYSECGDGSPAVYTCVDDLCRGYDLTRLoYspslFTEpVLGh-lsPP........hhsVlVhlRNptT+sp+sVRlPs..oo......loLF.ulYNhl+phhh+h.pLDssLlppLcpYhstlPs.h+poc..pl.tpp.h........	0	0	0	0
+1713	PF02239	Cytochrom_D1	D1_heme; 	Cytochrome D1 heme domain	Bateman A, Mian N	anon	Pfam-B_3322 (release 5.2)	Domain	Cytochrome cd1 (nitrite reductase) catalyses the conversion of  nitrite to nitric oxide in the nitrogen cycle. This family represents the d1 heme binding domain of cytochrome cd1, in which His/Tyr side  chains ligate the d1 heme iron of the active site in the oxidised  state [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	369	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.20	0.70	-6.16	8	7650	2012-10-05 17:30:42	2003-04-07 12:59:11	11	55	672	42	338	8166	222	221.80	52	91.82	CHANGED	phshtNLFsVs.RssGplsllDGDspc.luhl-otYAl.HhShh.us.GRYlYVhGRDGtlohlDLaspc..hVAEV+hGhsuRulslS.....-s+allsGsYhPsphslhDucTLE.lpllsTpGhssss....spsRVuAllsu.h+spFVVslK-TGclhllsYosh.cslpTppIsuA+aLaDuuassstRYalsuh.ups...KlslhcsccGthssLlDs.G+ss+sh.sushsH.phG.hWssuphtshshshIGpcshs....hhctpsWKhlppIsstGsG.lFl+THPcSpalWVDshhsP-...scuVtVhDpcsL.........lshsltshsGhs.......VlpsEFs+cGDpVWlSVWsucs...ALVVaDs+TLcLh+sls...hhoPoGKFNVaNs	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AuIlu..S....pP-.alV.Nl.K...E..T.G.pI.L.L..V...s........YpD............l.....c......N....................L....p....................s......T...............s..I............s....A..A...+......F.L..H.......D..G...Ga.....D....u....o.....+....R.....Y...F...Ls.A.....A.....N.t.Ss..............K.lA..VVD..o.K.....-..p.......K...L..s.......A.....L....l....Ds...sc..h.P.H..P.G.....R...G.AN.a.s....cPc.a.......GP.V..W.....sT..u.....t.........L..G..s-..s....l.o...h...IG...T....D..Ptp..........H..p.p...A...WKVVp..slc..G..p...GG..G..SLFl.KT.HPp.Sp....pla..s..Ds.s..hs.P-.......thup.o.l.s.Vach..tsh......................h.h.....l...t......st.......................................................hhp...cas.tG.p....hhh....................................................................................................................................................................................................................................	0	91	229	292
+1714	PF02109	DAD		DAD family	Bateman A	anon	Bateman A	Family	Members of this family are thought to be integral membrane proteins.  Some members of this family have been shown to cause apoptosis if mutated [1], these proteins are known as DAD for defender against death.  The family also includes the epsilon subunit of the oligosaccharyltransferase that is involved in N-linked glycosylation [2].	20.20	20.20	20.30	21.10	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.48	0.71	-4.02	30	370	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	306	0	230	340	0	104.90	45	83.17	CHANGED	sus....h.s.llsphhppYhspTP..p+LKllDAalhalllsGllQFhYCsLl.GsFPFNSFLSGFIosVGpFVLslsLRlQlN.......tNcspF.hulSs.ERAFADFlhAsllLHhlslNFIG	....................ss...h.sllpphhppYhssTP..p+LKllDsalhalllsGhlQ...FlYshLl.GsFPFNuFLSGFlSsVGpFVLslsLRlQlN......................pNttpF..tslSP.ERAFADFlhusllLHhllhNFls.......................................	3	77	127	189
+1715	PF00130	C1_1	DAG_PE-bind; C1;	Phorbol esters/diacylglycerol binding domain (C1 domain)	Bateman A	anon	Prosite	Domain	This domain is also known as the Protein kinase C conserved region 1 (C1) domain.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.82	0.72	-4.23	46	6123	2012-10-02 13:15:50	2003-04-07 12:59:11	17	344	330	24	3317	5447	1	52.60	31	8.26	CHANGED	HpFttp......sa.tpssaCstCsphl...........h.htppGhpCp....hCphpsHc+..CtptVsstCsss	...................HpFhhp............sa..pp..Ps....hCshCpphl.........................hG..hhp.QGh.pCp..................tCp.h.s...sHc+..........Ctp.plsspC...t..................	0	793	1126	2107
+1716	PF03982	DAGAT		Diacylglycerol acyltransferase 	Finn RD, Wood V	anon	Pfam-B_11378 (release 7.2)	Family	The terminal step of triacylglycerol (TAG) formation is catalysed by the enzyme diacylglycerol acyltransferase (DAGAT) [1,2].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.82	0.70	-5.72	6	1100	2012-10-02 00:16:30	2003-04-07 12:59:11	8	11	361	0	723	1216	48	230.60	28	64.76	CHANGED	ahLFhTspWhllsLYulWhhYDhsoP++GuYpssWsRphtla+aFAsYFPlpL.hKTu-.Lsss+NYlhGYHPHGIlulGAassFuTsuTGlhcpFPGIR.plsTLs..GpFhhPaRREhhlhhGhI-sSRESI-alLs+stp.G+AlVlVlGGApEAL-AHPGpcsLTLtsRKGFV+hALcpGApLVPsYuFGENDlYcQh-NPcGSpLRphQchhK+hhGhoPPlFaGRGlFs.hshGLLPaRKPlsTVVGtPIpVsKs.cPTpEpIDclHuhYh-tLt-LFEEHKsKaGls.sspLllp	..............................................................................................................................h.............................................................................................h......p...................h.hph..h.h.t..Y..F..s.h.pl....h....p......s.....t....h.........s.p..p....p..........Ylh.uh.aPH.Gl.hs..h..u.h.....hhshs.......p.......................t....................h............t..............h....hs.t.h.t..........l.....h..sls.....F...h.....h.P.h...h.R-hh.h......h.....G.hs.ss.scpshth...h...L...........s..........p...........t...........t...........t...............lhll.sGGst..E.u.L.....p.s......p..s....s..p............p..l....hL.p.p.R.+GFl+l.AlppG........s......s.......LVPshsFG..E.......s.......-.......l.......ap...h................t........h....h..............h...t.......h.h....t....p.h........h.t.....h...s.....s..h.h.......h..u.....h........h.........................h............P.h..p...............t.s....l..h........V...l..G..p....Pl..............l..............p................p.P...s........p.......lpt.h.+.t.....ah.t.tL.plapph+..h.s...............h..................................................................................................	0	239	386	554
+1717	PF01219	DAGK_prokar		Prokaryotic diacylglycerol kinase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.90	21.90	22.40	25.20	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.08	0.72	-4.44	186	3222	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	3038	3	605	1802	403	102.60	36	78.24	CHANGED	htYuhpGl.ttshppEtuFR.clhhullllsluhhl......slothEhhlllhslhlVLhsEllNoAlEslVDhlu..-aH.LuttAKDhuuuAVhluhlhusllhhhllh	.............h.tauhpGl.tsAhp.pEtsFRpchhhsllslshu.hh.l......slstlEhllLlhulhLVlhlEllNoAIEslVD.hlu....s-aH..Lu+pAKDhuuuAVLlshlhA..s..lshhllhh.......................................	0	181	367	508
+1718	PF00609	DAGK_acc	DAGKa; 	Diacylglycerol kinase accessory domain	Ponting C, Schultz J, Bork P	anon	SMART	Family	Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.	21.30	21.30	21.40	21.90	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.18	0.71	-4.09	42	1202	2009-01-15 18:05:59	2003-04-07 12:59:11	14	102	195	0	702	1147	5	153.50	36	20.57	CHANGED	sMsNYFSIGhDAcluhsFHptRppp..PthapuphtNKh.hYst.hGspc.hh.ppshtsh..cplplc..................s-sppl....plP..ssculllLNIsSauuG.sshWssspppt...................at.tshsDGhLEllulpushclutlpssltps.hRluQu.spl+lphpp............phshQlDGEP	..................................................................................................hNNYFulGh................DAp..luhcFHptR...E.cp......PpK.....Fs...S..Rh.pNK..............h......hYst.hGspc......hh..ttot.+s...L..ppplp..lp................................................................sDGptl....pls...slpu...Is.hLNIPS..asGG.sshW..Gsspcpp...................................................ats.phsD.thLEVVGlp..ss.....hphu.t..lp.......s...s.h......t....ps...hRl....AQs.pplplphpp................slPhQ..lDGEP.....................................................	0	211	323	501
+1719	PF00781	DAGK_cat	DAGKc; 	Diacylglycerol kinase catalytic domain	SMART, Coggill PC	anon	Alignment kindly provided by SMART	Family	Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family [5].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.93	0.71	-4.71	125	7254	2012-10-02 15:20:27	2003-04-07 12:59:11	19	132	3378	25	2390	5666	830	128.70	23	30.86	CHANGED	phhlllNPpu..Gpppsp.......plhtt.h..ppt..h..p......h..pl.hps..p..p..tsss..pt......hth.hts.hsph...............tllss.GGDGTlspVlsul...........h...p......p...sh...................s...lullPsGTuNshA+slth.stshtt............................................tthhthht.pht..sp...ssthsph	............................................................................................hhllhN.P..p.S..Gp.ppst......h.......tplht.h..h...ppt...t....hp....................h...pl...hho.......pp.......tssu...pp....................hst...hts..hssh...................................shllss.GGD....GT....lsc......V.lsul.................................................h...p......p.sh.................................s..lull...P..h..G.T.u.N.DhA+.sL.s.l..s.ts.tt............................................th..hhht.th....hsh......t..........................................................................	0	772	1353	1927
+1720	PF00793	DAHP_synth_1	DAHP_synthetase;	DAHP synthetase I family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1032 (release 2.1)	Domain	Members of this family catalyse the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.	19.80	19.80	20.50	20.10	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.66	0.70	-5.71	28	8958	2012-10-03 05:58:16	2003-04-07 12:59:11	15	18	4112	276	1994	5818	4302	285.30	28	87.41	CHANGED	chsls.t.............slhhGpspphlllsGPCSlEs.-tsh-hAp+Lpplus+ht..lhllh+uah-KP.Rooshua+Ghh.-stLphhtclpcsh..............GlslsTEhlDstssphlA-hsslhpIGARsscspshlctAuthspPVslK+Gps....sulpthtsAuchhhhhGs..........ssslhhC-RGlRsGc.tsNppshDlpulshhpcts.hh.......PlhlDsSHusup+s...........hh.p.hVsshspuulAsG...hsGlMlEsH.sPupAhsD.......usptLsht...shtphhh-hsphlhp	...............................................................................................tthhpht...................plhhGp...D...p..chlllsGPCSlc..s.-tsh-hAc+.Lt.s.l...s..p..c..h..t....l.lVh+saa-KP..posh.ua+GL....ht......-......st.......l..c.hhhclpcsh.................................GlP.s.s.T.Ehh-s.ss....p.h.l.u.D.l.l........s........hhtIGARs.scs....pshh....c....hA.....u......t....h.......u..t......P....VshKpGps..............luhsshtsAs..p...h..th.h.G........................spss...hschhl...R...s......G......p..t......sN....h.t.s.hD..l..tsss.....h.h.hpts....tl................sl.llD...soHusup+s...........htp..p....hVs.p.............s......p..s......t...lusG.................lsGlMlEo..H.s..s...uptp.s.-........us..p..tlsh...u.p.hs.hshhhp.sp.h.t....................................................	0	632	1204	1652
+1721	PF01474	DAHP_synth_2		Class-II DAHP synthetase family	Bateman A	anon	Prodom_1974 (release 99.1)	Family	Members of this family are aldolase enzymes that catalyse the first step of the shikimate pathway.	19.40	19.40	22.40	19.50	17.40	19.20	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.44	0.70	-6.12	111	1570	2012-10-03 05:58:16	2003-04-07 12:59:11	11	4	1229	18	510	1307	2300	383.10	49	93.61	CHANGED	pWsssS...WRspPhtQpP.sYPDtstLpplpppLpphPPLV.FAuEscpL+ppLApVApGcAFLLQGGDCAEoFs-hsuspIRcph+llLQMAlVLTauuuhPVVKVGRhAGQaAKPRSushEsh.....-G....lsLPSYRGDhlNuh-FotpuRhPDPpRhlpAYppSAuTLNLlRAaspGGhAc.Lc.plcp.......WshsFl.tpushup+Yppl..........AscIscuLpFMp....AsGhs.t......pl..............................ppschaTSHEALLLsYEpALTR......................h.............D..opo.Gp.........................a..YssSAHhLWIG-RTRQlDuAHVEFhRGlpNPIGlKlGPohss--llcLl-tLNPc....sEsGRLTLIsRhGAc+lpctLPtLlcsVcppG+p..VlWsCDPMHGNThpus..sGaKTRpF-cIlsEVpsFFclHcup....GoasGGlHlEhTGp......sVTEClGG.upsls-.pDLssRYcTtCDPRLNupQuLELAFLlA	..........................................puWcsh.s.h.hQtP.pYsDt..t..tltpV.tpLpphPPLVh.AuEscp....LcppLApVupGcAFLLQGGDCAEoFsphss....spI+s.ph....+...llLQMA...lVLTauuph.PVVK.lGRh...AGQaAKPRSsshEth..........s.GlpLPSYRGDhlN.Ghphstpu.RhPDPpRhlpAYtpSuuTLNLlRAhspGGhAsLc..plcp........Ws..hsFl..tp..o.......t.t+Yptl..........ApcIscuLt.FMp....AsGls..........t.tL.........................................pps-haT.S....HEA....LLLsYEpAhTR.................................................................h.................D.....sts...sp.................................h..YssSuHhlWIG-.R....TRQlDsAHV-FhpsltNPlGlKlGPshss--llpLh-h.L..sPp.............s.-sGRLTlIsRMGuc+ltstLPtllcsVptp.G..p..p..VlW.sDPMHGNThpus..........sG.aKTRtF-pl..hsEVpuFFclHpu.....GoasGGlHlEhTGc......sVTEChGG......u......pslop....psLssRYcTtCDPRLNspQuLELAFllA.....................	0	158	324	433
+1722	PF02733	Dak1		Dak1 domain	LOAD	anon	LOAD	Family	This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29. 	25.00	25.00	26.10	25.40	23.90	23.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.91	0.70	-5.87	9	2939	2012-10-02 12:41:15	2003-04-07 12:59:11	12	12	2046	34	705	2165	413	309.40	40	77.08	CHANGED	LtGLspuNPs.Lsllpcs+Vlhpsss.....s.sKVullSGGGSGHEPsHAGFVG.cGhLsuAssGpIFASPSoKQIaoul+AV.puspGsLlIVKNYTGDILHFGLAAE+A+AtGhpsEllsVuDDVSVG+p+suhVGRRGLAGTlLVHKIsGAAAtpG...LsLcpVsplAcplssNhsTIGuSLsHCTlPGpchpsp............LscsEhElGMGIHNEPGht+tuPlPolD-LVuc.hLchLLspssc-Rsa.................VphsssD-VVLLlNNLGGsS.hELhsltppls-pL.pcasIpPsRshsGsasTSLsGsGFSITLlpsocsstchhcthscssshsssh	...............................tGhshu.asp...l..p.h.h....t..s..s..p...l.l.h.+tch.......tpsKVullSGG....GSGHEPsHuGaVG.cGMLsAAssGplFoSPos-plh.p.A.h.....+.................s.s.......c.......s...............G..t...........G...V.LhllK........NYoGDlhNFchA.....s.Eh..A.c.t.......-....G..............l....c.VcpVll..sDDlAlp..s..s..h...............hs...ssRRGVAGTlhl......aKlsGAA.A-pG........tsL-p.lt.p...luc........+ls..s.....p.....s+..olGlALssCTlPusG.+ss..F.p...........L.s...-.sE..hEhGlGIHGEPGhc+pph..ps...ucp.lspp.hhs.......pllpp.....hs........................................h..t..t..u.......c.cVhlLVNGlGuTPl..ELallhscl.t.ph.L..p.p..pGlp.lt+sh.l.G..s..ahTSLDMsGhSlTLl..c.l..D.-..-.h.h.t.hh.ps.st.......t.......................	0	221	420	588
+1723	PF02734	Dak2		DAK2 domain	LOAD	anon	LOAD	Family	This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.	23.70	23.70	23.80	23.70	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.98	0.71	-4.60	175	4573	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	2828	8	1004	3192	390	167.00	29	41.01	CHANGED	slGDGDpGtsMspGhpushctlpsh.......ttsshuplhpslupshhpssGGsSGslauphhtuhupsl.....ps.ppp........h..ssps.hupulpsuh.pulpph.u......tAcsG-+ThlDsltPsscshpp.sht.......tsh.phhptuspuA.cpuscsTtshh.sphGRAthluppsh.G......hsDsGAhuhshllcuhtp	...........................................luDGDpGsNMstuhpustcplpst.....................spslu.....plhpshutslltsstGsSGslh..........uphFtuhupsl..............ps..ppp.................l...sspp.lup.u..hpsul.suhpuh.........scss-tThlsVhtss....scuhpp..utp................tts..h.t.............h....h...ptshcsAcpuh.ppT..shl..Ath..GRA..........G.......hlDsGupuhhhlhpuhh.p.....................................................................	1	338	633	857
+1724	PF03045	DAN		DAN domain	Bateman A	anon	Pfam-B_1968 (release 6.4)	Domain	This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges.  This family of proteins has been termed the DAN family [1] after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling.  It is postulated that all members of this family antagonise different TGF beta Pfam:PF00019 ligands [1]. Recent work shows that the DAN protein is not an efficient antagonist of  BMP-2/4 class signals, we found that DAN was able to interact with  GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo [2].	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.34	0.71	-4.70	20	362	2012-10-02 16:54:34	2003-04-07 12:59:11	10	7	107	0	209	428	0	113.40	30	56.02	CHANGED	phhpctlhctsttu.....hshppp.h+pshC+shPhpQpl.sc-GCcshsltNphCaGQCsSaalPpp...t...........hpsCupChPs+hpthplsLpCsups.s......hKcVhhVccCpCpssppc	...............................h.....................h.thh.h+pshC+spPlp.Qsl...pc..p...G...Cpu.p.s.l.N+hChGpCs..Sa....h..l...Ppp......ptts...............................hppCsp.CpPtchphhhVsLp.CPshps.s.p...........hK.pl....tpl..c..pCpC.sh..t........................	0	42	63	121
+1725	PF01266	DAO		FAD dependent oxidoreductase	Finn RD, Bateman A	anon	Prosite	Domain	This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.02	0.70	-5.55	530	27418	2012-10-10 17:06:42	2003-04-07 12:59:11	19	195	4663	179	8594	47340	28561	332.00	16	72.99	CHANGED	-llllG.uGlsGhusAhpLuc.........pGh...pVsllEpp.phut..................................usS...s.ts..uGh..lpsth.....................................................pts..hh.hp.hs.hpuhph....hpp..............................................................................................h.....hpph...................shs....h.....t.h.ptGtlhls.h.......sppp..hp..th.............tt.hp..hhpp.tsh......thc.....hlstp.phtph............................s.hs.....s.........th........hu...............u........lh.hsssu.hl..cstphstult...p....................t..s.t..p.t......G..sp......lh...ppsp.....V............psl......pt..psst.............................................ht.lp...............................s.....t.pu........p.hps.............ctllhAs........Gs....as....sp.l.ht.h.sh............................................l...........hshcu....h..lhhp.......s................htt...h.....................h......h.........................................................t.hhh...........hh............................h.h.............h..........................................................s.tp..sp.......h...............hs............sshsth.............................................t................................................................t.......................tl.......................................................................h..ptht.......phh...Ptl.............................................tpspl.htt......a.sG.........................................................................................hc....sh..s.......................................................................sDth.............................................................hhtt....ht.slhhs..tGhss................Ghth....usssGc.hluph	.....................................................................................................................................................................................................cllllG....uGlsG..h..u..sAhtLsp..........................tGh......pV.s..l..l-..t...p...t...h.ut.................................................................s..s....o.........s...t...s.........s.u..h..l.tst.......................................................................................................................................ttt.....h....h...h..p.....h......s.........t.....u...h....p..h......h.t.t........................................................................................................................................................................................................................................................................................h................ht.p.h......................................s...h..t.........h..............t........h.....................u.....h......l....h..l....t...h................p.t..t.p.........ht.....h........................................t....h.......t.........h.....t.t.......hsh..................th.p.............................h..l...s.....t...t......p.....h....t..t..h........................................................................s.ht......t.....................h..................h.s..............................u..............h.h.........p..s...s......h.....p.......s........t.....p........h.....s...h.....s....h.h....p...........................................................................t...s..t..p..t......................G....sp....................................l..h....t.t..s...p........V................p.s..l..........tt....p...s..st.............................................hh....l..p.........................................................................................................................s......t.p.s..........................p..lpA..........................ct.l..l...........A..s...................G....s............h..s..........tp...l...h.t...h...t.h...............................................................l...........hs.....h....c..u.........h...h....h.ht.............................................t.t...h...................................h...............................................................................................................t..........h................h..h.h..........................................h.h.........t....h..h..hu.......................................................t...tt......h...........h.s.............s.s.........................................................................t..................................................................................................................................t.th.......................................................................................................................................................................................................................................................h....p..t..h.......p.h...h........P..t.h.....................................................tt.h...p.h......tt........h..s.G..............................................................................................h.h...........sh....s.......................................................................s-th.....................................................s.h..s..t.............................h............s.....h........h...hs.......u..hs..t...........................G..h....t..h....u.hhup.hhs...................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2308	4853	6950
+1726	PF01678	DAP_epimerase		Diaminopimelate epimerase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_2089 (release 4.1)	Domain	Diaminopimelate epimerase contains two domains of the same alpha/beta fold, both contained in this family.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.47	0.71	-4.20	28	7321	2012-10-03 03:02:41	2003-04-07 12:59:11	14	6	3504	42	1855	5624	4219	119.90	25	83.62	CHANGED	hshspGsspshlhls-hcp...tshhp.......hsttlps+pthssusslhalp......sssctclphR..........lapssuuEsptCGsG.stshuthlhptth......tppslpVcs.uG.lhlplpsssp.....hh.hGssphl	.......................................................................sh.hGsspshhh..l....D..s..h..sp...........ts.h.s...........................hu..t.l..p..s..+...p.....h......h.....s........s.t.s..s..lhhlp.........................hssc.s..c..h..chR................................lap.p.s.u.u..EsptCGsG...st...s.s..u...th...l..t...p...t...t..h..................tpp..p..l..p.Vps.....u..G.p....l....t..l..p.h..p..s..sst.............hh.hG.s........................................................	0	612	1251	1586
+1727	PF05173	DapB_C		Dihydrodipicolinate reductase, C-terminus	Studholme, DJ	anon	Prosite	Domain	Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate.  This  reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The C-terminal domain of DapB has been proposed to be the substrate- binding domain.	20.80	20.80	21.00	21.10	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.70	0.71	-4.38	189	4343	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	4160	36	1018	3039	2348	134.50	37	51.96	CHANGED	GlslhhplscpAAchhss....aDlEIlEhHHppKhDAPSGTAlplu-slspst......................t....pt.thhs.p............sp.IslpulRsGsllGcHpVhFsutsEplplpHcAhsRp..sFAtGAltAAcal....h...s.p.....G...lYshpDlL	..........................................Glslhhclhc....pAA.+.h..hss.....hDlEIlEhHHccKlDAPSGTAlphuEsIAcsh................................spph....tt..thhsccth............ttts.ssIshpolR.u..G..slV.Gc..HpV.......hFus.tGE..p..l..p..IpHcAt.s.Rt..sFAsGAlpAApalt.........s....+..........sG......lYshpclL..................................	0	327	676	865
+1728	PF03344	Daxx		Daxx Family	Finn RD	anon	Pfam-B_3933 (release 6.5)	Family	The Daxx protein (also known as the Fas-binding protein) is thought  to play a role in apoptosis, but precise role played by Daxx remains to be determined. Daxx forms a complex with Axin. 	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	713	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.35	0.70	-6.04	7	169	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	84	2	75	167	0	470.80	32	71.69	CHANGED	hAhsDsIIlLD.DDDtEEtsspPusS.sss..sts......ph..PKlpQPhsscIstusssou++csasLpsENpKLFpEFV-aCpspTpDpPEVlsFL+s+puKASPpFLuSVEF+NhLuRCLoRAQu+RoKsaVYINELCTVLKtHSsK++...lplpPsuups.....tp.t..PT-sh..s.......................Sup.pspc-p....tt-tppp+uSRRQItYLENLL+hYscEI+RLQEKELSLpEL--EDSoYIQEu+LKRK............................Lh+IapKLCELKGCSSLTGRVIEQRIsYpGTRYPElNRR....................IERFINtPEupps.PDYsDlLptlp+ANERHuLsLoRKQLpthAQDAFRElGsRLQERRHLDLVYNFGSHLTDsYKPusDPAL.DPoLAR+LRsNRplAlS+L-pVISKYA.hQD-TEEtERpK.RpE+ctpsspup.....tp.shtsssuspuP.hhtup-s.sppps-p-p-----.pp..p........psptt.--.-EE-pE.psssc.-p-h-sus-upusspEccpstp................................ttp..+..ohsspSPpspPtps.sh-.p..sEppcpphltp-pslSsHhphstluhs..............ppphsPsslshsLppsusshhopopsussoscsspppss.pt+pRpc+..........c.htut.hhsusl......h.csGpchp.LPhshsslsS.ushpspSopsDoPopt.sTso..........pTP..sPh+s...KlsVATQCDP-ElIVLSDS-	.....................................................................................................................................................................................................................................s...altShtFpshlspshschptp.tp...haValpplss.Lpt...ct....++p..........p...h..sssptt............ss.....shp.............................................................................................t..pp.............ttpt.pppt.pc...c...pIthLpph..LthhstcIp+LpctElshsp.pc.D....SsYlp.t+hK++............................hhplat+lC-Lpspss.ssRhlcp..I..a..puTcYPclN+p.........................lpphlNp................ps.............hPDYtDlLphlp+........sstccsLsLsc..pphp.h..Ap..-AFpclG.hLQcRR+.DhhYshu..sHlTss.....sh..DPAh.Ds.Lhp+LcpNppht.s+lp-llpKYu.hQ-.p...ct...ptph.p..tc......tt...................pt..tt.......tt.......t....t...tt.t....t................................................tt...ptt........t..........t.....................t.................t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	23	28	50
+1729	PF02277	DBI_PRT		Phosphoribosyltransferase	Mian N, Bateman A, Moxon SJ	anon	Pfam-B_5739 (release 5.2)	Domain	This family of proteins represent the nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) enzymes involved in dimethylbenzimidazole synthesis. This function is essential to de novo cobalamin (vitamin B12) production in bacteria. Nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole (DMB) phosphoribosyltransferase (CobT) from Salmonella enterica plays a central role in the synthesis of alpha-ribazole-5'-phosphate, an intermediate for the lower ligand of cobalamin [2].	22.60	22.60	23.00	22.90	21.50	22.50	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-12.10	0.70	-5.34	26	2551	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	2248	35	647	2021	520	317.80	35	85.49	CHANGED	llsplsssDstshstspp+.spLTKP.GuLG+LEpluhpluuh....pGps.P........sls+s.tlhVhAusHGVstpGVoshPtpVTsphlpNhht......GGAuIshlsppsGssl..c....VlDlulct................csoushsptsAM..occcsttulthGhchhtp.hstGs-LlshGE.hGI.GNTTsAAAlhuuLhGssspphVG.G.oGlsspsh..........p+KhslVccAlt.hppssh...sDPl.-lLsplGGh-lAAhsGhhLuAAhp+hPVllDGalssuAAllutp.lsPtshcahlhuHhSsE.GHthhLptLuhcPlLsL....shRLGEGoGAsLAhslVcuAsthhptMuTatpAsV	......................................................................................................................h....l.s.D.tt.hh.ttspp+......ctLsK.P.G....SLGpLEpluhp.lAuh......tup.t..s.....................pltc...tlllhuuDH.G..Vh.t......c.....G..Vos..h.P....ppV.T.t...t...hstN..h.h.t......Gsu..ulssluppsGs..p..l..p....VlDl.Glsss....................................................hph+ltpG.o.sshs....ptsAM....o..p..cp...s..ttulttGhphs.pp..h.h..........p.p.G.s.s.l.......lsh.GEhGIGNTTsA..uA.lhuslsG....h...............ss..p....p.....s....V.....G...h....G....s.Gls.s.st.l.............t+KhsllccAlp.....hp...p....s.ps.................pD....sl......-......lLu.plGGh-lu....uhsGshLuAA.p.p..p..hP...VllDG.Flss.uA..A.L..s.A..s..p....l....s....P............ss......psahlsuH.hS.sE......Gt....ph.hL..ptL...........u...........h............c...P...h...L.sh.....shRLGEGoGAs..LAh..sllcuAsthh.s.pMushttutl........................................................................	0	206	432	555
+1730	PF03880	DbpA	YxiN_DEAD; 	DbpA RNA binding domain   	Bateman A	anon	Kossen K	Domain	This RNA binding domain is found at the C-terminus of a number of DEAD helicase proteins [1].  It is sufficient to confer specificity  for hairpin 92 of 23S rRNA, which is part of the ribosomal A-site. However, several members of this family lack specificity for 23S rRNA. These can proteins can generally be distinguished by a basic region that extends beyond this domain [Karl Kossen, unpublished data].	23.10	23.10	23.20	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.86	0.72	-4.31	173	3567	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	2412	2	811	2655	411	73.50	30	13.56	CHANGED	sphplslG+ccplcPtslluslsscu.slss.ppIGpIclh-paoaV-lsps.hscphhpplp..psplp.G+plplchh	.........phpIssG+c.cp.lcstcIlGAlss-u..s...lsu...ppIGpIclhs..s..aohVplspu.hspcslpplp..ps.+Ip..G+phplph.h........................	0	257	512	682
+1731	PF04290	DctQ		Tripartite ATP-independent periplasmic transporters, DctQ component	Mifsud W	anon	COG3090	Family	The function of the members of this family is unknown, but DctQ homologues are invariably found in the tripartite ATP-independent periplasmic transporters [1]. 	27.10	27.10	27.20	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.66	0.71	-4.39	186	5361	2009-09-13 06:40:50	2003-04-07 12:59:11	7	9	1674	0	1467	4565	5259	134.30	19	65.70	CHANGED	hhhlhhhpVlhR..hh....h.....t.shs.h.spE.lsthhhlhhsh.luhuhshpcspHlplcll...hptl.ssphpthhp.hlssl.lshs...hss....hlhatuh...................................hhhhhtttptssshs...lPhhhhh.....hs...lsluh..slhsl...thl.hplhph.hps	.................................................shllhhpVlhR....ah......h..............................spshs..h..s....-E.lst.hlhshhshlG.uuhsh.t..p.st.H.l..pl-hl..........hp.tl...ssp.h...pp..h...lp....l...lspl...lhlh....hsh..................hlhh.huh..........................................................hh.s.h.ht.h.s.p...h..o.ss.hs............ls.h.h.h.hh.............hs...lsluh....slhh.l....htl.tplhp.h..t.........................................	0	440	995	1263
+1732	PF03605	DcuA_DcuB	Dcu; 	Anaerobic c4-dicarboxylate membrane transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.70	20.70	20.70	21.30	20.10	20.60	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.29	0.70	-5.62	10	2671	2012-10-02 15:12:49	2003-04-07 12:59:11	9	3	1383	0	245	1239	66	350.30	44	83.13	CHANGED	ElllVLlslFlGARhGGIGLGlsGGlGllILsFshtlsPus..hPlDVhLIIhAVluAuAsMQAAGGLDahlQIAEKlLR+NPKplTlLAPlVTYhhTlhuGTGHsVYSlLPVIu-VAhcsGIRPERPhSsAlVuSQlAITASPISAAVVhhlAhLss......pulshLoLLtVsIPoTllGsllhulhsh.hpGK-LccDP-YQcRLscshh+phshspp......clssoAKlSVaIFLsullslVlhAsssslpsuhh..s....psluhshsIphFMLssuuLIllhTKlDsssIspusVF+SGMhAslslaGlAWLuDTahssHlspIKsshupllpsYPWhaAlsLFllShllsSQAATstsLlPlul.ALGlsP	..........................................................pllllLlslalG.ARh.GGIulGhhGGlGlllL.s.h.s....ht.lpP..Gp.......PhDVhLlIhAVluAhushQsAGGLDhhlplAE+lLR+NPKaITllAPhVTahhTlhsGTGHlsaohLPlIs-VAhcpsIRPpR.PhuhusluuQhuIsASPlSAA.VVhh.s.u..h.Lts.........tsl....s....al..plLulsIPoTllulhlhuhh.s.h......hhGp.-.....LscDs..YQcRLpcs.h.cthshtpp...............cl.p...sA+hSlhlFLhu.llsVV........lhushss................ps...........uhs..............p................slshstsI.hhMLssusLIhllsKss.sspIs.ssslF+uGMsAslsl.hGlAWhu-Tahs..u..phs.IKsshupllp....saPWhhAllLFhsStll.SQAATstAlhPl.uL.ALGlsP..................................................	1	41	118	193
+1733	PF03606	DcuC		C4-dicarboxylate anaerobic carrier	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.46	0.70	-6.26	13	3902	2012-10-02 15:12:49	2003-04-07 12:59:11	10	5	2105	0	339	3372	265	444.50	24	97.14	CHANGED	hPthhsllhhlhlhhhIlohahPsGsatpts..................................hl.hhhsshhspspslssshtssttthhs..hhphshh.hpscAsslshFIhhlGGhhulls+oGAh-sslttls....KhhptpcphhIhhlhshFshsssshGhsEto...lshhslLhPlhlslGasthsususlhhuossGhhuuThNPhslVlAupsAGlslt-GhhhRllshslhslluluasaaYsp+lpccP......hpp.cEppphhphcpup.sss....ssthhhhLhhhshlhhlhu.........h.h.hls.....................paahsplsslalhhulllsalth...hsshpsp-hhpuFhcGhuchh.sAhlVuLA+Gltlhhpss.....hhlsTIlshhssuhoshsu..lhhllhhllhhhhuhllsSGSG.AhhoMslhsPLAchlGlstshlllshQhusslsphluPTSGlVhAsLuhu+luhtpWlKhsus.lshhlllshlslllthh	...............................................................................................................................................................................................hhsllhh.l.hlhhhlhphhh..PsGhh.h.t.........................................................................................h.l..h..h.h..s..s...hh...t.t.......t....sl..s.....s.......t......s..t.......t....hh...s..........................th............h...........hhs...puss...lh.h.h.IhhlG.G...h..h..ul.hp.+oG...A.-sslt.tl.s............+......h...p...........s...h...c....h...h..I......h.l..h..h.h.h.sh..s.s......h.s.h.uhs...p..ts......l.s.h.h.s.h.L.h.P....l....h.ls.lGhcs..........h.su...sus.l..h............hu....s..t..h.u....h....h..u............s....s....h............s.....................s.......s.......s....l.......A..........u...........p.......h......A.......G..........l........s.....h....h....s....s....h.......h.......h........+.......h....l...h...h.......s...l....s...s....l..l..s...l..h...h...s....h...h...a...s....p..+....h....p.cc...............................p.........t...c....p....t.......p...t....h..t..h.....p...t....s....p.........p...p.......p......hp.........t...p...t......h..h..h....l.....l...h..h..s..h..l...h.....h.l..h.u.......................hhhp................................................................................th.ah...s..p.h....s....s....h.....h..h...h..h..u.l...l..l.t.h.lt.........s..h.p...p.shhps.F...h...c.Ghu...s..h...............s.......Ah.l.V..u...l...s.h..u..h..t..l..h..h...p...sh.................hh.h.s...o...I...h...s...h....h...s..t...s...h...s...s...h..s.....s....h......l...hh..l...h..h..h..l..h..h.......h..l..huh.hh.sSuou.uhhhhs.l.hs.P..L..A....c.h..s.......G.....ls...t....t........h..h...l.h...s....hphusshsph.lsPs...o..............u....l....l..hushu....h..u.....+.........l.....s....h.h...p.hl.K..h...s..u..s..h..l....h..l.h..hl.h.sh.lhhhh...h..........................................................................................	0	106	193	281
+1734	PF03184	DDE_1	CENP-B; DDE;	DDE superfamily endonuclease	Mifsud W, Bateman A	anon	Pfam-B_2254 (release 6.5)	Family	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localised to the centromere.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.35	0.70	-5.20	20	3031	2012-10-03 01:22:09	2003-04-07 12:59:11	14	109	208	0	2383	3243	38	158.50	17	38.69	CHANGED	hsscslaNhDETGlhhshhsstt....s..ttpth.stpt..pcchTshlsssusuuc+L.PhlIhKups.cshph..................htpshshpacssppuWhosplht-WL.chFssphp........s.sc+hlLlLDuasuH..ssph......hhpNltllalPspsopllQPhDhGlhsshKtpYRpphhphhltstsshps...........................t.shhchlchhtpAWp.ulspcsItsua	..................................................................................................hhsh.c.p.....h.....t.................................................................................p......p...p.h..h.hhh...s....ts..s..s...hh.........h.h.lh...t...t....t........................................................................h......h..t......p.t...pu.a........h.s..p.......t..hh..t...ah......p...h.....h.....ht......................tp....hhL.lhDs.....h.ts..H....s.th........................t..p..l.....h.h.h.....h........P........s.........p.s..op......h.............h............Q............P.......h.....D......h.....s.....hht.sh.K...th..h.t.t.h.......t.h.........................................................................................................................................................................................................................................	0	825	1401	2161
+1735	PF02862	DDHD		DDHD domain	Bateman A	anon	Bateman A	Family	The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues.  This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3) [1]. This suggests that this region is involved in functionally important interactions in other members of this family.	23.30	23.30	23.70	23.30	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.45	0.70	-4.56	51	906	2009-01-15 18:05:59	2003-04-07 12:59:11	12	34	250	0	612	855	0	183.70	25	23.63	CHANGED	LcFcscshFhhGSPlGhFhhl+ttph.sp.............................................s.ssphspPsCcplYNIFHPsDPlAYRlEPLlssphup.lcPh.lPptppt.hhtht........................................ctlsslusphptsht.......................ht...h.pt.s.stpspp.tpsss.pph...............................................................................p.pppp.ppp....tttphphttLNsst......RlDYsLp.tu..sl-..spalsslsuHsSYWpspDsstFllpplhp	................................................................................................................................................................hpFcspthFhhGSPluhhLhl.+th.t.......................................................s.......hs...tCp.phaNlaHshDPl.AhRlEPhl..pht.......l............tPh..lPh..hpt.h.h.hp.ht.................................................................................................................................h.pthttt....h..............................................................................................................................................................................................................................................................................................................................................................................................................................h..h.thh...t..s..t...............RlDa.L....t....lp......ph.h.sh....HhsYWpstDsshhllpplh..........................................................................................................	0	170	259	468
+1736	PF03345	DDOST_48kD		Oligosaccharyltransferase 48 kDa subunit beta	Mifsud W	anon	Pfam-B_3520 (release 6.5)	Family	Members of this family are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosyltransferase (DDOST), also known as oligosaccharyltransferase EC:2.4.1.119, transfers the high-mannose sugar GlcNAc(2)-Man(9)-Glc(3) from a dolichol-linked donor to an asparagine acceptor in a consensus Asn-X-Ser/Thr motif. In most eukaryotes, the DDOST complex is composed of three subunits, which in humans are described as a 48kD subunit, ribophorin I, and ribophorin II. However, the yeast DDOST appears to consist of six subunits (alpha, beta, gamma, delta, epsilon, zeta). The yeast beta subunit is a 45kD polypeptide, previously discovered as the Wbp1 protein, with known sequence similarity to the human 48kD subunit and the other orthologues. This family includes the 48kD-like subunits from several eukaryotes; it also includes the yeast DDOST beta subunit Wbp1.	36.00	36.00	36.20	46.60	35.90	35.40	hmmbuild  --amino -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.42	0.70	-5.95	29	360	2009-09-11 12:44:55	2003-04-07 12:59:11	9	6	276	0	243	382	1	379.40	35	87.94	CHANGED	sLV........llDstsp+tp.........aShFapsLcs....R.GacLsacssc..s..ssLsLachGEhhYDpLllFssp.s+shGss..lo.scsllcFlssGGNlLlssSup........hsculRplhpEh.slch.s-csshllDHFNaDst.sss.pHslll.....h.tsshlpssspshht......tslha.+Gsuthlss..ssLlhPILpAspTuY.......SYs..scpchpsh..........sausGpQshLVuuhQuRNNARhsasGSh-hhpDcaFsutspt..............posNp-FAcplopWsFpEpGVl+lsplpHa+ts-st............sP.phYpIK-plhYoIplsEa.....sps+WlPFp....s-DlQLEFsMlDPahRhsLp...........tpp..tsushYos.pFplPDpHGlFsFclsY+RsGhTplpcpspVoV..RphsHsEYsR..hIsuuasYhuuhauslsGalhFshlaLappss...........KKpp	......................................................hLVll-s...s.+pp........aShFapsLps.........................RGa..pl.sacsscs......spLsLhchGphhYDpL.l.lhssp....sc.p...........hGss..ls...spslhpFlcs.G.GN.....lLlA.soss.........hscslRplhsEh.Glch.s-csshVlDHasYcst..........s.s.pHshll................h.sps.h...l.p..ssshst.tt........sslha..+GsGhshss.tNsLlhslLpAs.sTuY............................Shtscpthpph...............shssGp.phhLluuhQ.....AR.NNARlshsGSl-hhoDpaFsutlpt.........ttp..pouN..tphupplopWsFpEpGVL+ls.slpHa+sscst.........................sP.phYplpDpl..................pYoltlpch.....ssscWhP.ap..........sDDlQLEFshl-PahRh..sLp..........................psuhYps.pFplPDhaGVFpF+VcYp.R.GhTpl.ppppVoVR..htH.spY.R..hIsuAaPYhuusaShhhGhhlFshlaLa.p...............p.........................................	0	87	137	203
+1737	PF04625	DEC-1_N		DEC-1 protein, N-terminal region	Kerrison ND	anon	DOMO:DM04594;	Family	The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1].  Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa).	27.90	27.90	27.90	58.00	24.90	27.80	hmmbuild  -o /dev/null HMM SEED	407	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.41	0.70	-5.79	3	34	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	13	0	12	48	0	338.70	58	37.51	CHANGED	MMFPALGSLLRWGSLFPAYSILGAIPDNLQPTAAASKVVLVLADDATAKTRVARQNPPPNPLGQLMNWPALPQDFQLPSMDLGPQVGSFLAQL...PAMPo...MPGLLGAAAPVPAPAPAPAAAPPsAPAPAADoPAAPlPDAsQPAILGQAALQNAFTFLNPSNFDASSLLGQSVPTFAPPNLDFVAQMQRQFFPGMTPAQPAPAGTDAQASDISEVRVRPEDPYSQEAQMKIKSALEMEQERQQQVQVKDQEQVPLLWFRMPTTQNcDATEEKTLEDLRVEAKLRAFERQVIAELKMLQKIELMAKQMRSSAAAQNGDSPYRISYPLSRTPIHKITRADIEQALRDDYVRRLVNKEAQRKARNSGINTQKANALKRQAKSQDQTLSKEDIVQIMAYAYRMANEQMESEKG	.....................MMFPALGSLL+WGSLFPA.SlLGAlPDs.L.....QPtAAASKVVLVLADDAs.uKoRVsRQs........sP..PsP...h.Gph...MNhPAL......PQsF.....Q....L...so....M.sL.s...PpVGp.hL...u..QL.Ps.MPs.....hsul..LGtAsPV.Pss..........APAsss...sPs.AssPAs-sPs..sssP..ss..s.Ps....ushtsuhsFhsPuNFDuS.sLLGQu...lss.....................APP.shDFhuth.RQFaPGhsPA.pPusu.soDAQASDISEVRVRPE........s.............s...a...uQ.pAQ...M...KhKSALphEQE+Q........cspEpVPLLWFRMPo.......opsp..-ts-pKolE......DLRVEAKL+AFERQVIuEL+MLQpIEhMAKpMRoSA...suQss..soPY+lsYPLSRTPlHKITRADIEpALRDDYVRRLlpKEAQRKu....tsp......tsuhKRQstpQ.-QshSKE-IVplMAYAYRMAsEQh.Ep...................	0	3	3	7
+1738	PF04624	Dec-1	DEC-1_REPEAT;	Dec-1 repeat	Kerrison ND	anon	DOMO:DM04594;	Repeat	The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1]. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). This repeat is usually found in 12 copies in the central region of the protein. Its function is unknown.  Length polymorphisms of Dec-1 have been observed in wild-type strains, and are caused by changes in the numbers of the first five repeats [2].	20.90	20.90	21.20	20.90	20.30	20.70	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.71	0.72	-4.31	7	107	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	8	0	43	192	0	26.40	68	12.46	CHANGED	QNsMMM.p....RQWoE-QAKhQQp..QQMhQQ	.QNPMMMQQ...RQWoE-QAKlQQs....Q.Q.hQQ........	0	24	24	37
+1739	PF02352	Decorin_bind		Decorin binding protein	Bashton M, Bateman A	anon	Pfam-B_800 (release 5.2)	Family	This family consists of decorin binding proteins from Borrelia.  The decorin binding protein of Borrelia  burgdorferi the lyme disease spirochetes adheres to the  proteoglycan decorin found on collagen fibres [2].	24.60	24.60	95.30	94.90	21.60	20.90	hmmbuild  --amino -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.68	0.71	-4.17	12	159	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	30	0	2	132	0	139.20	56	78.15	CHANGED	KhtLESSuK-IpDEIsKI+K-AtscGVNF-AFpsspTGSKVupss.hIhcAKl+shslstKFlpsIEEEAhpLKEsGu.Sup......FpuMYDLML-lutsLEclGlppMppoVoptAcpsPsTTA-GIltIspthcsKLppV+pKQ	..KltLESSuKDIpDEIsKIKK-AsspGVsFcAFT-scTGSKVo......ps......s...hIh-AKlRAhslsEKFlpAIEEEApKLK-oGu..SGc......FSAMYDLMLEVScsLE-lGlpcMppTVo-AAcpsPsTTA-GlLtIAptMcsKLppV+pKp........	0	2	2	2
+1740	PF01335	DED		Death effector domain	Bateman A, Finn RD	anon	Bateman A	Domain	\N	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.56	0.72	-3.86	37	947	2012-10-01 21:41:45	2003-04-07 12:59:11	16	55	86	20	419	826	0	81.10	24	27.28	CHANGED	aphhlhp.lscsLspc-lcsLhFLsp...c.lspsc..hpp.pshh-lhhp.Lccpshls.ssl....shLtclLtplsRhDLLptl.phcppsh	.........................ahthLhp.lu-pLspc-lp.sL.p..FLhp......-.h..lsppc.............hpp...pssh-lhhp.Lccps.hlsp..ssl....shLpclL...ppl..p..RhDLlppl.phcpt.................	0	158	186	257
+1742	PF00711	Defensin_beta		Beta defensin	Bateman A	anon	Pfam-B_675 (release 2.1)	Domain	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.44	0.72	-4.02	54	464	2012-10-01 20:50:19	2003-04-07 12:59:11	14	4	80	69	141	484	1	34.50	32	54.72	CHANGED	s.hpChppsGhCh.tpCssthp.pIGo..Ctssth+CC+	......hpChtptGh.C.t.hhCs.hhhp.plGs..Ct.sshhp.CCh....	0	4	4	18
+1743	PF00879	Defensin_propep		Defensin propeptide	Bateman A	anon	Pfam-B_517 (release 3.0)	Family	\N	21.00	21.00	21.20	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.53	0.72	-4.01	23	253	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	31	0	76	259	0	49.60	48	52.36	CHANGED	MRTLsLLuA.lLLlALQsQA-slQtps-Es.ssQ-QPGtEDQDlulSFssscuo	...M+TLsLLuA.lLLlALQsQA-...sl.......Q.s..ps-.......Es.ssp-QPGt--QslulSFstscs.............	0	9	11	16
+1744	PF00323	Defensin_1	defensins; 	Mammalian defensin	Finn RD	anon	Prosite	Domain	\N	21.40	21.40	21.60	21.50	20.10	21.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.88	0.72	-3.58	11	136	2012-10-01 20:50:19	2003-04-07 12:59:11	14	3	22	60	56	185	0	29.00	47	32.72	CHANGED	ChCRpt.tCttpERthGsCplpGhhashCC	.CaCRth.sCtttE+hsGoCp.ht.Ghhaph.CC	0	5	5	8
+1745	PF01041	DegT_DnrJ_EryC1	DegT_DnrJ_EryC1_fam;	DegT/DnrJ/EryC1/StrS aminotransferase family	Finn RD, Bateman A, Parkhill J	anon	Pfam-B_239 (release 3.0)	Domain	The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA Swiss:P72454, StsC Swiss:P77952  and StsS [1]. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyses the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.04	0.70	-5.42	38	8204	2012-10-02 18:26:03	2003-04-07 12:59:11	12	29	3491	78	2089	27677	18092	342.00	27	92.75	CHANGED	sthsp-.httlppslcus.hhhs......GshlppFEccFAsahG..staululsSGTsALhLALtA...hulu......GDEVIsPuhTFsATssslhtsGApPVFVDlD......ssTaslDPstlEsAITs+T.....KAIlsVHhhGpss.DhssltclAccauLhllEDsAcAhG..upapG...................+hlGshG..chusFSFassKsl.osGEGGhllTsDscLscphc........th+saGhs.........ppahpph............hGaNh+hs-lpAAlGlsQLc+l-phlppR+chsphapptLtslshh..hshsspss............tuaahaslhhptp....s.RcpLhptLppp..slsoplha......s.Ph+tpsh.........appht.tss.thPsu-plspcslsLPhassls...s-clccVssslp	..................................................................................................................p.hthltps.lpos...hl.s.s.............G.s..h.s..p..p...h..E......p....t......h..s....p...a........h........G..........s........p.................a.........s.........l........s.........s........s.........S.........u....T....s....A..L...p.l....A...Lhu....................ls...lt.......................G...D....E..V...I....s......s......u......h......T.....F......s........A........T.....s......s.....s.....l......h........h......h........G........A.....p..........P.....V......F.........l......D.....l.....-.............................c.....T.....h.....s.....l....D....s.....p.....t....l............E...t....s....I.......T........s.......+...T.........................+...A........I......l.......s.......V.......H.......h.......h........G.......t........s.......s.......-.......h.......-.......t.....I..............h.....t.....l...............u....c.....c......a................s.................l..............h.................l.l..E.D......u...A.....p....A....h.G.....u.....p..a.....c..G...........................................+.t..s..G......s..h..G.......c....h.u.s.a..S......F..a...s......s...K.sl....ssG..E.....G....G.h.l......h......o..s......c......p......p......l.h...c..c..hc...............................................hl.p..p.p...Ghs.................p.p...h.htph....................................................hG..hN...h..+...hs..-l...p...AA..l.s....h....s.....Q....L...c.p.......l.........-..p.h.....h.p.pR.....p..p.l.sp...hY.....pp.t.L........t....s...h...s...........h............h..t.h..s..stsp.........................................psaa..ha.h.lh...l..............p....t.................t................................................p......Rs........t.....l.h.ptLppp.............sI...t.s.....t.h.aa................hsh.a.t..p.sh..............................a.p..p.....h.....t....................................p.....h.s........scp.ht.p.p.hlsL..P..hast.hs...ppp.hphlhpth.h..............................................................................................................................................................................................................................	0	739	1465	1821
+1746	PF02286	Dehydratase_LU		Dehydratase large subunit	Mian N, Bateman A	anon	Pfam-B_7927 (release 5.2)	Domain	This family contains the large subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.	25.00	25.00	41.80	41.80	17.40	17.00	hmmbuild  -o /dev/null HMM SEED	554	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.61	0.70	-6.26	11	398	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	338	20	44	238	19	512.60	77	98.83	CHANGED	pRpKRFchLscRPVN.DGFltEWsEpGhlAMsSPNDPKPS.lKI-NGpVlEhDGKttpDFDhIDcFIAcYuIslspAEcsMshDSlclARMLVD.NVsR-EIlclTouhTPAKlsEVVupLNsVEMhMAhQKMRARRTPuNQAHVTNh+DNPVQIAADAAEAulRGFcE.ETTVuVsRYAPhNAlALLVGSQsGRsGVLTQCSlEEAsELcLGMRGhTuYAETISVYGTEpVFTDGDDTPWSKAFLASAYASRGLKMRFTSGuGSElhMGaAEGKSMLYLEARCIhlsKuuGVQGLQNGulSCIGlsGAVPuGIRtVLAENLIshhlDLEsASGNDQsFSHSDIRRTARhLhQhLsGTDaIhSGYSulPNYDNMFAGSNhDA-DaDDY.lLQRDLtVDGGL+PVsEE-lIulRpKAA+AlQAVFctLGLPsITDEEVEAATYAcGScDhPpRssVcDlKAApplhsRGlTulDVVKALucsGFsDlAEslLshh+QRloGDYLQTSAIhD+capllSAVNDsNDYtGPGTGYRL..otERW-cIKslstAlcsp-lc	.....MRSKRFEsLAKRPVNQDGFVKEWlEEGhIAMESPNDPKPS.IKI.NGtVsELDGKshu-FDLID+FIA+YGINLsRAEEVMuMDSVKLANMLsDPNVpRs-IV.LTTAMTPAKIVEVVSpMNVVEMMMAMQKMRARRTPSpQAHVTNlKDNPVQIAADAAEuAhRGFDEQETTVAVARYAPFNAlALLVGSQVGRPGVLTQCSLEEATELc...LGMhGaTsYAETISVYGTEPVFTDGDDTPWSKGFLASuYASRGLKMRFTSGoGSEVQMGYAEGKSMLYLEARCIaITKAAGVQGLQNGSVSCIGVPuAVPSGIRAVLAENLIso.LDLECASuNDQTFoHSDhRRTARhLMQFLPGTDFISSGYSAVPNYDNMFAGSN.DAEDFDDYNVlQRDLKVDGGLRPVpEE-VIAlRNKAARAlQAVFsshGLPsITDEEVEAATYAHGSKDMP.ERNlVEDIKhApElls+shsGL-VVKALupGGFsDVApshLNh.Kt+loGDYLHTSAII.............stDhpVlSAVNDlNDYAGPuTGYRL..pGERWEEIKNIPsAlDPs-l.s...........	0	14	25	34
+1747	PF02288	Dehydratase_MU		Dehydratase medium subunit	Mian N, Bateman A	anon	Pfam-B_7081 (release 5.2)	Domain	This family contains the medium subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.	20.60	20.60	20.60	37.50	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.27	0.71	-4.33	62	717	2009-09-11 12:54:19	2003-04-07 12:59:11	10	2	336	26	77	386	10	113.30	44	63.61	CHANGED	stPAhslhhppshss....tll+pllhGIEEEGlshcl.p.shcsuDlshhAhpAAphSs.ulGIGlpuc......ssllH.+sL.s.ssL.hhs...hhstcshRtlGpNAARhsKG...hPh.	.............s.uPAhslttssshsu.....pll+EVlhGIEEEGI.scl.c.....phcuuDVshsAhpuu+.Ss.ulGIGlpu+......osVlH.+sLPs.usL.hhs..shhs.csaRplGpNAARhsKG.....P...........	1	27	44	59
+1748	PF02287	Dehydratase_SU		Dehydratase small subunit	Mian N, Bateman A	anon	Pfam-B_6588 (release 5.2)	Domain	This family contains the small subunit of the trimeric diol dehydratases and glycerol dehydratases. These enzymes are produced by some enterobacteria in response to growth substances.	25.00	25.00	38.30	38.30	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.44	0.71	-4.43	17	370	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	338	20	44	205	7	135.80	66	81.96	CHANGED	os+p.hstsDYPLspK+P-hlKTsoGKsLcDITL-sVlsGcVsupDlRIoP-TLchQApIAcssGRsAlucNFpRAAELTslPD-RlL-lYNALRPaRSoKpELLsIAcELEspYpAslsAsalREAA-sYcpRcKL+	.......................ou.csspVsDYPLAsKHPEaVKTuTsKoLDDhTLENVLSscVoApDhRITPETL+hQApIA+DAGR-pLAhNFERAAELTuVPDDRILEIYNALRPYRS.TKpELLAIAD-LEs+YpApICAAFVREAAtLY.cRKKLK..........	0	14	25	34
+1749	PF00257	Dehydrin	dehydrin; 	Dehydrin	Finn RD, Bateman A	anon	Prosite & Pfam-B_3306 (Release 7.5)	Family	\N	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.50	0.71	-3.89	27	1293	2009-09-17 10:00:38	2003-04-07 12:59:11	14	12	182	0	114	1285	0	110.70	26	87.32	CHANGED	sshhcchGsslthssthppttttttst.........................................................................s.httptts.....................................................................ttthtthhppst...SuSSuuSE--sp.........sGc+.................................................................KKGltEKIKEKLPGspps...............t....sttssshstt..........................................................tttEKKGhhDKIK.........EKLPu..............Gpc	...............................................................................................................................................................................................................tt...........................................................................................................................................................................................................................................................................................................................................................................................................................................tpp-ptt.............................tt.c.+.................................................................................................................KK.G..lh-K..IK.E..KL.P.Gsppc.............................................................s.t...t.h.t.t.....................................................................................tpp...shhtp..........................................................................................	0	23	58	87
+1750	PF02336	Denso_VP4	denso_VP4; 	Capsid protein VP4	Mian N, Bateman A	anon	Pfam-B_19701 (release 5.2)	Domain	Four different translation initiation sites of the densovirus capsid protein mRNA give rise to four viral  proteins, VP1 to VP4. This family represents VP4.	25.00	25.00	42.50	40.10	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.45	0.70	-5.48	3	29	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	21	1	0	36	0	370.00	36	70.57	CHANGED	DVTMAMSLPGTGSGTSSGGGNToGQEVYlIPRPFSNFGKKLSTYTKSHKFMIFGLANNVIGPTGTGTTAVNRLLTTCLAEIPWQKLPLYMNQSEFDLLPPGSRVVECNVKVIFRTNRIAFETSSTATKQATLNQISNLQTAVGLNKLGWGIDRSFTAFQSDQPMIPTAToAPKYEPVTGsTGYRGMIADYYGADSTNDsAFGNAGNYPHHQVGSFTFLQNYYCMYQQTNQGTGGWPCLAEHLQQFDSKTVNNQCLIDVTYKPKMGLIKPPLNYKIIGQPTsKGTISVGDNLVNMRGAVVoNPPEATQsVoESTHNLTRNFPAsLFNIYSDIEKSQlLHKGPWGHENPQIQPSVHIGIQAVPALTTGALLVNSSPLNSWTDSMGYIDVMSSCTVMESQPTHFPFST-ANTNPGNTIYRINLTPNSLTSAFNGLYGNGATLGNV	.......................t.....hsLPGTG.u...spu..s..s.Gusspu.tp......lh.I.RPhs.s.h.s..pph.pTYpKsHKFhoFGlAsslls..s.u.T..ssss..s..s.....h.hlTTsLAEIPWcp.hhYMN.SEFcLL...P..s..GSplh-ssV+VlhRssRlAFETsSosTs.ATLNQ.p.lthAhGL..Nph.ua...GhsRpaTsFpu...spPMlPsustsspYtslsstp..tacshlt.-hYGssssss.shstssshP+HplG..hhLpsYashht..p....s.......s..p.ss........u......GWPsLsp+lppaDupsssspsll....shoYcPphu.lpsshp...h..h.hhs...P...st.us..h.....t..tshss.......hp.....t.....ssh..s.....hs.....t..t.p.s.ps..h.........s..p..........ap.....hhs.IEKuQhh.tG.h.t..psphQPSlHlGh.sV.tLTTsth..............................................................................................................................................	0	0	0	0
+1751	PF01791	DeoC		DeoC/LacD family aldolase	Bateman A	anon	Bateman A & Pfam-B_6806 (release 14.0)	Domain	This family includes diverse aldolase enzymes.  This family includes the enzyme deoxyribose-phosphate aldolase EC:4.1.2.4, which is involved in nucleotide metabolism. The family also includes a group of related bacterial proteins of unknown function, see examples Swiss:Q57843 and Swiss:P76143.  The family also includes tagatose 1,6-diphosphate aldolase (EC:4.1.2.40) is part of the tagatose-6-phosphate pathway of galactose-6-phosphate degradation [2].	22.50	22.50	22.50	22.50	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.50	0.70	-5.07	26	7750	2012-10-03 05:58:16	2003-04-07 12:59:11	4	17	3919	241	1426	4608	1164	223.40	24	84.08	CHANGED	phhhhhDpsshpsshpst..............-lcsllpcshph.......tssuVslssshlthupcthsp......clshlluhstusshsssp...........shpsccAlc.GAstlchll.ht..tscp.ppphhpclptltctCp..shslhlllE.shhpspp............p..hltcAsclst-..hGADhlKssss...........t..htsp.pssphh+csstt...................lhsSGGl.........cslcpAh...cAGA..............hGsusGRslapp	.....................................................................h..hhhlDpshhps..psstt.................clctlsppA..hp..............................tssuls.l.s.sph.l.h..h.s...t.c..th..s.t.............................pls......h....l..l...s.ast....ussh.ss.s.p..................shpsc.pA..lp...G..A..s...tlchll.ht.........tu...tp....tpphh...ppl....p....t....lhp..t..s..t.............shs...l...h..l..llE.....shl...pcpp......................t...l.hp.A.s..cl.u.tc.....hGADhlKTpss.................t...sssp.....ps....sp.h.hpchss.....................................................l..hsuG.Gl...............cshppAh..hpuGu.ph............hGs.sGhthht.t.............................................	1	479	902	1203
+1752	PF00455	DeoRC	deoR; DeoR;	DeoR C terminal sensor domain	Finn RD, Anantharaman V	anon	Anantharaman V	Domain	The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site [1]. DeorC  senses diverse sugar derivatives such as deoxyribose nucleoside  (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR) [1], [2], [3].	31.80	31.80	31.80	31.90	31.70	31.40	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.56	0.71	-4.60	91	14356	2012-10-04 00:26:15	2003-04-07 12:59:11	17	16	3216	0	1875	7048	402	159.00	26	63.33	CHANGED	tpphpcKppIActAAphlps.GsslhlDsGTTshtlActLssp........slsVlTNulslAptLtpps........shclllhGGplcppstuhsGshshphlppap.hDhuFlussGls..ctGlts.s.p-stlccthlppAccshllsDpSKau+puhhphsslsplstllTDps	.................................................h.phppKptI.Ac.t.A.u.p.hl..p..s..G...p..s.lhlDsG.oTshtl.uctLs...pp...................slsllTN.ultlA.p.h.Ltc..p................php.l.l.lhGGplc.p.....p..st..u..hl..G....s.h.shp.h.l.....p.....ph..p........hDhsFlussGls...............h......p.t...G...l.s.shs...............pc..............stlppthlpp.u..p.c.s.lll..sDpSKa..s..c..p...u...h....hph...s.sls.pl.s.h.llTDp.t................................	0	508	1030	1467
+1753	PF04511	DER1		Der1-like family	Mifsud W, Bateman A	anon	Pfam-B_1901 (release 7.5)	Family	The endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae contains of proteolytic system able to selectively degrade misfolded lumenal secretory proteins. For examination of the components involved in this degradation process, mutants were isolated. They could be divided into four complementation groups. The mutations led to stabilisation of two different substrates for this process. The mutant classes were called 'der' for 'degradation in the ER'. DER1 was cloned by complementation of the der1-2 mutation. The DER1 gene codes for a novel, hydrophobic protein, that is localised to the ER. Deletion of DER1 abolished degradation of the substrate proteins. The function of the Der1 protein seems to be specifically required for the degradation process associated with the ER [1]. Interestingly this family seems distantly related to the Rhomboid family of membrane peptidases.  Suggesting that this family may also mediate degradation of misfolded proteins (Bateman A pers. obs.).	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.32	0.71	-4.81	11	816	2012-10-01 23:21:32	2003-04-07 12:59:11	10	13	329	0	563	905	24	176.70	28	69.86	CHANGED	lPsVTRhahhusllholls+hpllsPhhLh.asasLlh+KhQlWRLhTshhaa...ushGapalhNhaFhapYsptLEpusFps+.........ssDalahLlFshlhhshhsh......................................................................ph...hhLspshshhllYlWuphNs.psplsFatlhphpApYLPalLhshshllts.ssl.s-lhGlhsGHlYa....Fhp.................hYstp.tGpcLlpTP.	...........................................hP.lTRhahss....slhh...oh...h...s.....p.h...t......l.l....s..s....h...p....lh...hs..................p.....h..lh....p......c.h...........Q...l..W.Rll....Tsh..h....a.a...................u.s.hu..h.sh.lhp..hhal....hpYs......phLE..p...s...t..F.psp...........................................uDa.h.ah..l.l.a..s.....h.hhh.hh.h.u..h..................................................................................................................th.......h..L..u..ps...hhhh.l..l.Y..l..W.....u+.p....Ns...phpls......aahl.h..sh..p.A..a.LP...a...s.hh.s.h.shl....h....ss.....s.....hh....sc.lhGlhsGHlYa.........Flp................phaP.........t..G.h..p.l.sP.....................................................................................................	0	203	316	457
+1754	PF01880	Desulfoferrodox		Desulfoferrodoxin	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Desulfoferrodoxins contains two types of iron: an Fe-S4 site very similar to that found in desulforedoxin from Desulfovibrio gigas and an octahedral coordinated high-spin ferrous site most probably with nitrogen/oxygen-containing ligands. Due to this rather unusual combination of active centres, this novel protein is named desulfoferrodoxin [1].	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.63	0.72	-3.71	58	594	2012-10-01 19:22:21	2003-04-07 12:59:11	13	10	502	39	225	540	29	92.40	38	70.61	CHANGED	osDstpEK.....HVPVIE...pspsG....VpVpVGp..lsHPMppcHaIpWI-Lhs.cpsth.......RtthpPss.............c..PcspFslph.t............................splhA.hpYCNlHGLWcsc	...........................s.sDsutEK.....HVPVlc.......htss.....lpV.p......VGp....ltHP.Mp.....pc......HaI.pW.IpLhs...s.p.s.sh..................+tpLpPsp..................c..PpApFtls.s..t...........................tsltAhpYCNlHGLWcs.p............	0	114	181	211
+1755	PF04598	Gasdermin	DFNA5; 	Gasdermin family	Mifsud W	anon	Pfam-B_5153 (release 7.5)	Family	The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form [1]. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells [2]. This family also includes the gasdermin protein [3]	30.00	30.00	30.20	31.00	26.90	29.80	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.42	0.70	-5.74	18	326	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	45	0	165	276	1	322.80	23	90.11	CHANGED	hF-+so+sll+Els..pGDLlPVssLpsus+Fp.asLVp+K+cp..hFWp.s+YhslshoLtDlLEPss.......ssPsssposs..hpapsthcsplpGslclshs.hphpluGuu...opSstsolclQplslss.th-sh..cR+lhs.cs..................shLpphp....ppt..-sLaVVTEslpTsp-sslpcsspsctpsph.lst.shslpGpuptp......pspcpsloIPpGosLAY+lhQLhl..cpcspatlslh.ccKptTFtp....................................ph..p..h..................h.....sssptpsstptshpsLcpE...lcpphpsLscLscphppsLhssltplLpDcpsLpsLEphL-th..............tltsh-ssstslLppLht..........ssshh.pphtsslhYLLsALs.LS-sQttLLupuhEhplLstphcLVculh-pshp......hs.............LpsthLusLtscth.sls.tLhtpsGlclp..tssPcssh	...............................................hFttso+shl+pls...t..GcLhPVpsL.sus+hp.hsLVh+K.pp......hhat.scah...hs..hoLhDlLpsst..............s.....p.t..t...hph.s..tsphpup....hth.........ht..hpls..Gps....s.sp.stlphpplpls..hhc........p......+.....+h.p.c....................hlpphp....ppt..psL.hVVhEhlpshpps.lp..tttphpt...t.h.......h.h.h.......h..thpsp...........hspphhltlPt.tsslAathhpLhl....p..h...th..hh..t...p...t.sF..................................................................................................................h.t....h....t.h.....Ls...p..l.t.h.t..hh...pp..h..L......ht........................t.t......h.th.................................................................h...hh.hltA.l...hsc.t..hl....h..p.t...l....p.....h...t................................................................................................................................................	0	13	19	43
+1756	PF04127	DFP	dfp;	DNA / pantothenate metabolism flavoprotein	Wood V, Finn RD	anon	Pfam-B_6559 (release 7.3);	Family	The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.32	0.71	-4.67	702	5121	2012-10-10 17:06:42	2003-04-07 12:59:11	10	12	4486	16	1366	3993	2687	170.90	33	49.56	CHANGED	LtG.++..l..llTAGPTpEsIDPVRaIoN+SSGKMGaAlApuAtptGAcVTL.l....u.GP.s.s...ls..s....P......s..l.p.hlp.VpoAp-MhpAlh.pt...h......sps......Dl.hIhuAAVADa..RP....tphus.pKI...K.K....t......sst.hs........l..pLhcsPDILt.....pl.u......ttpp...........tt.....h.lV..GFAAE..T.p........slhcpA...cpKLp.....+KshDhIlANslstts.......tG..Fus.Ds...Nplp.ll	.............................................................tshpl.llTAGsTpEsl..D..P....V..R...aloNcSSGKhGhAlApsh.hp.t..G.A....p.VsLl.....s.Gs..s..s..............l...s...............P..........t....l...p..hlp...Vpo.u...t.-.M...h.....ps..l....pt..............h.............tpt......-l.hIhsA.AV.uDap..s....................t.p.h....s..s..p.......K..l..................KK.......p.................tspths................lplh...csPD...Ilttls...t.t.t....................tp..............h.llGFAAE....T..p..........sl...phA.ppKL.t.....+.KshDhll.ANs..lst..........s...Fss.spNtlhh.......................................................................	0	450	859	1151
+1757	PF05035	DGOK		2-keto-3-deoxy-galactonokinase	Bateman A	anon	COG3734	Family	2-keto-3-deoxy-galactonokinase EC:2.7.1.58 catalyses the second step in D-galactonate degradation.	25.00	25.00	25.70	25.60	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.83	0.70	-5.66	51	889	2009-09-12 20:56:58	2003-04-07 12:59:11	7	2	751	6	148	615	193	280.40	43	93.85	CHANGED	DWGTosLRuWlhs.tsGp..llsp+puspGhtplssss............Fcss...LtsllusWhss..sshPVlhsGMlGSRpGWhEAPYlssPsshsslstthttls..s.ttsltIlPGls..ptssss.DVMRGEETQlhGsLs......psshssllClPGTHoKWVplpsGplssFpThMTGELFulLsp+SlLs+s....hssss.sss......AFtpGlppu....spssslsspLFulRuttLLttlssssutuhLSGLLIGtElAuspst..........hhspslsLlGussLsshYtpALsttGhssphls..u-pAshsGLtthsc	..........................................................................DWGoTsLRAWLh..ps.s.p...sL-pRp.u..psGlt+L....sspu.................sssLtclss......c..Wtp.......p...........s........s.P........VlhuGMlGSssGWp.APYLslPAthsulucpLssVs.......................csl..aIlPGls..........hpcs-s...sVMRGEETQLlGAht..................thussulhl.hPG.T.H.sKWVps.-......s...............t....pIscFRThMTGELapLLhp...HSllGsu..........ls.s...p...-...s...ss-........AFss.Gl.cpu....hsssul..LspLFplRAutll.G......sL......spp...psu-aLSGLLIGsElAuhpsh..............hstppsIsLlu.usuLs.uRYppAhpsh..Gh..s.s.stls..uDpAhpsGltplA.p............................	0	23	71	108
+1759	PF00926	DHBP_synthase		3,4-dihydroxy-2-butanone 4-phosphate synthase	Bateman A	anon	Pfam-B_1148 (release 3.0)	Family	3,4-Dihydroxy-2-butanone 4-phosphate is biosynthesised from ribulose 5-phosphate and serves as the biosynthetic precursor for the xylene ring of riboflavin. Sometimes found as a bifunctional enzyme with Pfam:PF00925.	20.90	20.90	20.90	22.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.17	0.71	-5.08	97	4699	2009-01-15 18:05:59	2003-04-07 12:59:11	14	20	3949	37	1250	3399	2646	192.70	49	56.26	CHANGED	lccAlpsl+s.GchlllhDD-s....RENEGDLlhuAphsTs-plsFMhppupGllClslstppsccLsLs.Mss..p......Nssth.....................tTuFTlolD.tp...s...ssTGISAtDRAtTI+tLu...........sss..spsp-FhpPGHlaPLhAcpGGVLpRpGHTEAuVDLs+LAGl.pP.suVlCEll..sc.DG.sMt+hs-..lhpaAccasLhlloIp-Llpat	.....................................l-cAlpsl+p.G+hVl.V.l.DDE.D....REN.E...GDLIhAAEthTsEpl....sFMh+au..........pGllClsloc-cscpLsLP.MVp......p......Nsssa.....................tTuFT.VSI-...stc...G...sTTGISAtDRupTlcshs.......................sss........upssDhsRPGHlFPLhApsGGVL.pR.sGHTEAuVDLs+LA..Gl.pP......A.GVlCElh............N-...D...........G...o...........MARts-..LhpFAccHsltllTIpDLlpYR.................	0	388	804	1055
+1760	PF00701	DHDPS		Dihydrodipicolinate synthetase family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_557 (release 2.1)	Domain	This family has a TIM barrel structure.	22.10	22.10	22.10	22.20	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.74	0.70	-5.81	13	10473	2012-10-03 05:58:16	2003-04-07 12:59:11	17	24	4601	330	2809	7818	5086	284.20	27	95.11	CHANGED	thtGlloAllTPFsspGplDhpuhcpLlcapIspG.s-GLlluGTTGEuhsLSh-E+hpllchsVspssG+lsVIAGsGSNuTpEAlchsppupcsGhcusLtVsPYYsKsSpEGlhpHF+sIh.stsslPhIlYNlPuRTusclsPEslt+Lup.hsNllGlK-ssGsh....thppl+ptsscshslaoG...-DspthshhphGucGsISVouNlssthhpshhctspsGchttA.ttlpc+LhPLhchLFtp..sNPhslKsALphlGlssss.hRhPhsPlsp-tptclsshlcthG	.......................................................................................................hpGlhsAhlTPF.....s..p..p.....G......p......l......D..h...p...uh.p...p.l.l.c.a...h...l......p.......p..G..s...s.G.l...h..ss..G.o...T.G..Ess..sLo..t...-......E..+.....t...pl...l....c...h...s...h.c...t...s........s.......u...........+..........l.....P.....l...I...A........G...s...G.......s..s...s...........T.p.c....u.l..p....h....s..c.p..A.p.c..h..G....s..D........ull.s.l...s.P...........a...Y....s.........+....s......o.......p......c..u....l...h....p.......H...a...c...s.......l......u.....p....u.....s.........s...l...P....ll.l..Y.....N..l...P.....u.....p...o..u..s.....s.l..s.s..-..s..l..t.c..Lu........c...h........s..s.l.l..ulK...........-....u....s....G....s...l.....................t.p...h...t....p....l.....h........p......t...........h...........s...........s........c..........h....h..l....h..sG..........sDs.h.h.h..s.h..h....t.....h...........G...u..p.......GsIos.....s.....uN..l.....h.P....c...t...h....t...p...h....h...c...t......h...t.....p.......G...c......h...p...p.....A......t.......pl...p..p...p...l.....h....s....l......h....p...h...l.....h.tt..............ss.s...h.......s........l...K.t...s......h.....p.....h.....h........G...h.......s.s..s....h...R.hP....h.s.s..h.sp..p.p.t.t.tltthht...h...........................................................................................................................................	0	799	1639	2295
+1761	PF01368	DHH		DHH family	Bateman A	anon	Pfam-B_1245 (release 3.0)	Family	It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null --hand HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.21	0.71	-4.55	150	10761	2009-09-12 04:54:29	2003-04-07 12:59:11	15	57	4504	39	2562	8005	1706	162.10	20	32.36	CHANGED	tlppscpl.hlhsch..DsDulsSssslhphlpphsh.pthhhhsspthpt.h...hsttth..............................................................................................................................................................................................................................................t.ttppssLllhlDs.utsshtthpttpth........hpll.llDHH..spp.h................lpsthhs..........hhc.hsuuusuhhlsphl...............................hspphtsllhhGhl	................................................................h...p.ppl..llhGch....D..sDul.sS.s.hs.....h.tp..h..h.....p...p........h........s......t..............p.........s.........h.........h.....h..l..s...p.....p.................s....s......s...................h.sh.h..thtt........................................................................................................................................................................................................................................................................................................................................................................tsslllhVDs...u...t....s.s..p....t...s..s..p...h..t.p..hs...............h.pl.l..llDHH...s.sp.h.....................................ss.hs............hhp..hsuu..usuh.hlh.p....h.l.pt........................t.....p......h.tphhs.llhhGhh................................................................................................................................................................................................	0	921	1749	2205
+1762	PF02833	DHHA2		DHHA2 domain	Bateman A	anon	Bateman A	Family	This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA2 for DHH associated domain. This domain is diagnostic of DHH subfamily 2 members [1]. The domain is about 120 residues long and contains a conserved DXK motif at its amino terminus.	21.20	21.20	21.60	21.60	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.58	0.71	-3.94	126	2132	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	1956	28	508	1459	93	128.40	35	33.02	CHANGED	u....h-hhcAtosl.sshosc-llptDhKpFsh.......su....ppluluQlpshshsplhscp..........sclhsthp.phtpcpshDhhllhlT......DIhppsohlLhhu..tptphhppAash.phps.sthhLp..............................GVhSRKKQllP.Lpcsh	.....................s.hpMLKAG.o.sl...ss.+.osc-LlshDhKsFph................su.................ppltluQVsslDl.s-lhp+p...................s-lcsshp.th.s..t....p..puh.......ch.hlLhlT..........................DIls.ss....SclLslG.....tstch.....lpp.AFsh.....pl.....p.....s......sp....s.hLs..............................................................GllSRKKQl.VP.Lpcsh..........................................................................................	0	175	314	423
+1763	PF01180	DHO_dh	DHOdehase; 	Dihydroorotate dehydrogenase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.95	0.70	-5.46	12	6787	2012-10-03 05:58:16	2003-04-07 12:59:11	16	50	4626	118	1697	6540	4232	282.50	29	80.42	CHANGED	hLssplhGlcapNPlh.AuGh.t.GpphsphhsLu.hGhl.ltusThpsp.GNPpPRlhchstu..hlNuhGhsN.GhDhlhpclh.hhpc.....................................lsI.hshstss.....h-DYltsscplu..shschltlNlSsPNs..Ghhshtpss-lst.Lspslpchs..................................................psPlhVKluPsls-.shhslAs.ht.tpsLshls....Tlpt.hlDl+stpslhts...tsGGLSGsslKslAlchl+plhphss..IPIIGsGGIpoucDAlEhhhAGAShlQlhTuh.asGPhlss+IhccL.phL	............................................................................................................................................................................s..tsphhGlphpNPlhh.A..u.G..h.s.p.p.u...p.t.h...t...t....h.....h.......s..h.......u...hGtl...htol.T......c..s....p..........G.........N.......s....p..........P..R......h.......hc.......l........s........p.......s...................................h..l.......N..t.h......G..........h.....s......N.............G......h......-...t.....h..hp...p..l..h.t.h...h...t.p...............................................................................sls.l....l.....u....hstto...............h..-..-...Y..h..ts.h.c.p..lt..............sh..s...s....h...l...plN.l....S.s.P.....N.....s...........u....h.t.....s........l..t..........t...s.....s.....p....l......s....p.h.....l....s.p.h...h....p...p..t.s..................................................phPlhl....K..l..u............P........s..l.s..-.......................s.....h...h.........s......h.....A........s...........t.....h.........h....t..........p......s..........l.s..............s.......l...hh.N.o.T..l......s.t....................s.....l...p.......s....h....t.....s......h......t..................thG.G.....l..S..G....t......s.....l.....p..s.....h.......u.......l.....c.......h.....l......p......p......l......t......p........p.....h..............p..............................t...........l......P.......I.....IGs..G.GIpos..cDA...h...E........h...l...h...............A.G.A.o...hV.Ql.......hT....u.h.h...a....p...G.P..t.....lspclhptL.th..........................................................................	0	544	1054	1421
+1764	PF01761	DHQ_synthase		3-dehydroquinate synthase	Bashton M, Bateman A	anon	Pfam-B_1327 (release 4.2)	Domain	The 3-dehydroquinate synthase EC:4.6.1.3 domain is present in isolation in various bacterial 3-dehydroquinate  synthases and also present as a domain in the pentafunctional AROM polypeptide Swiss:P07547 [2]. 3-dehydroquinate (DHQ) synthase catalyses the formation of  dehydroquinate (DHQ) and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate [1]. This reaction is part of the shikimate pathway which is involved  in the biosynthesis of aromatic amino acids.  	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.59	0.70	-5.47	95	4669	2012-10-02 14:41:14	2003-04-07 12:59:11	15	21	4283	45	1160	3985	3068	257.20	42	63.32	CHANGED	hlslssGEptKo.hpsht.plhstLhpts...hsRsssllALGGGVlGDlsGFsAAsahRGlsalQlPTTLLApVDuSVGGKTulNpshGKNhIGuFaQPpsVlhDsshLpTLPtRE..htsGhAElIKauhI.t.D...sshaphLcpp.tt........................ptpsLp......phI.......t+SsplKA.plVspDE+E.sGlRtl.....LNhGHThGHAlEshtsY......phh.HGEAVAlGMlh.s.uclutthGhh.s.tthp............clpplLpphGL.P...s.shsph.................ss.-pllph...httDKKsp	...........................................thhlPsGEptKs.hp.s.h.p..p.lhst...L.l.pps..h.s.R.s.s..s.llALGGGVlGDlsGFsAAoahRGlc.FlQlPTT.L....L..A.p.VD...S.....S.VGGK.Tu.l...N..p......s....h.....G.............K..N...h...lG...A..F...a...Q..P...p..uVlhDhshL.c.TLPtRE.ltuGh.AE....V.I....K....a.....G.l....I...t.D.....ss.......h.ap.hLE..pph.p.t.h.ht..............................stpsht......phI.................t+.u...s...p.l..K..A........cl...V..s.......p...D...E+E........s.......G........l........R...tl................L........N..h.....G............H...T.........hG.H..AIEsth.sY.......tphhHGEAVAhGMlh.A.u.cl.u.pp...h..G..hh..sptpsp....................+lh..plL.p.p.h.G.L..P......s.s.hsp.....................shpphhp.tMtpDKKs.t....................................................................................................................	0	401	765	1004
+1765	PF01487	DHquinase_I		Type I 3-dehydroquinase	Bashton M, Bateman A	anon	Pfam-B_2492 (release 4.0)	Domain	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase.) Catalyses the cis-dehydration of 3-dehydroquinate via a covalent imine intermediate giving dehydroshikimate. Dehydroquinase functions in the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Type II 3-dehydroquinase catalyses the trans-dehydration of 3-dehydroshikimate see Pfam:PF01220.	20.70	20.70	20.90	21.20	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.32	0.70	-4.70	150	2260	2012-10-03 05:58:16	2003-04-07 12:59:11	10	37	1982	52	564	1429	154	219.00	32	56.47	CHANGED	slslsspshtchhtphpphtt..ss.DhlElRl..Dhlp..................p.ltptlptlppps...shPllhTh..R...................sp........tEGGph.p..hsc....cphhpllcpshchs.......s-alDlElp..hppt.hht......hhhtppsts+lIhSaH.sFppTPshpp...lhp....hhpcht.phGsDlsKlsshspshpDslp.lhphppphp.....thPlIshsMGphGplSRlhsshhGSshoau..thspssAPGQlslpclpphhp	..............................................................lslhspshtph.h.p.p.hpthpph....ss....DllEaRl..Dahtt..................................................shcplhphhtt.l+cth...sphPllaTh..R....................ot........pEGGch...s.....hos.......ctYl....pLh....ctsh....phs..............sD.hIDl..........Ehh...s....t....pc..htt................ltttptpsspllhSpH...sFpcTP.ptcc...............lht...........hlpchp..p.............h.....s.s.D........lsK.lAlMs.ps..p.pDVLs...Lh....photphpp...........sspPl..lshSMuchGhlSRlsuplaGSshTFu.........shpcsSAP.GQlslscl+phh.p.............................................................	0	165	339	475
+1766	PF01220	DHquinase_II		Dehydroquinase class II	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.10	21.10	21.30	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.60	0.71	-4.86	191	2882	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	2604	343	840	2257	2156	139.20	48	92.52	CHANGED	hpILllNGPNLNlLGpREPplYGs.pTLs-lppplpp..tApph..u..lplphhQSNpEGpLlDtIHpA.....tsp..scuIlINPuAaTHTSlAlRD....Altul...sl.P...hlEVHlSNlHuR.EpFRH......+SaluslA.tGlIsGhGspGYplALcshhp	..........................plLllNGPNLNhLGpREPplYGs.tTL.s-lppplpp..t..A..p..p..h......u....l.c.lchhQSNpEGpLlDtIHpA....................tsp..scsIlINPuAaTHTSl...AlRD....Altul...s..l..P...hlEVHlSNlHsR..EsFRH......+SalSshA.tGlI.sGh.GspGYpLALpshh.p.................	1	251	526	715
+1767	PF04706	Dickkopf_N	dickkopf_N; 	Dickkopf N-terminal cysteine-rich region	Mifsud W	anon	Pfam-B_5838 (release 7.5)	Family	Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This family represents the N-terminal one [1]. The C-terminal region has been found to share significant sequence similarity to the colipase fold, Pfam:PF01114, Pfam:PF02740 [2].	21.20	21.20	21.20	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.92	0.72	-3.80	13	214	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	54	0	110	172	0	52.00	45	19.55	CHANGED	.ChsD--CssspaCptscpp.......thClsCR+p++RCpRDuMCCsGshClNGlChs	....................Ch.Dc-CssscYCptsp.t...........tChsCRc...p+...c+CpRDu.CCsG...phCssGhCh......	0	11	26	52
+1768	PF05086	Dicty_REP	Dict_REP; 	Dictyostelium (Slime Mold) REP protein	Moxon SJ	anon	Pfam-B_6278 (release 7.7)	Family	This family consists of REP proteins from Dictyostelium (Slime molds). REP protein is likely involved in transcription regulation and control of DNA replication, specifically amplification of plasmid at low copy numbers. The formation of homomultimers may be required for their regulatory activity [1].	20.70	20.70	114.70	114.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	911	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.66	0.70	-13.84	0.70	-6.79	5	10	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	5	0	2	10	0	732.20	36	98.23	CHANGED	scLIPWcsFhhFalpILE-FpPsKRsp..h..ss-IMsahYSs+sLlhKElFRolls+pph.....scphtDsLDlcoIFc+TSLhsh....spsscsDLDDllpI+Ks.psGKIlVoDsDQAIFIIDHFSRluDsQVFsKKsIsGFRslEKhVScsGYKIcDaRphGlcWFsFLNKlRTuCspachF....h.puhaKalDFISMLoslHsItVDcQN+-EEcLSslYoLYPFl-LE..........pp.s.t.pulsocNtpRpshpPsspsNsTTTTTTTTTTTTspshT+KR+thsspsls.s.t.....ps.tsssts.......................tsphpcpsSRKSGuLK-VRlDsIS...................s..hssssspSlsPs-sIlSlSN+IKsCLlEllpSKGEIso-lVKuIFcsLQsKsYosDLlDSIFsQNKSEKVITlSS+lFsluuKlDaDEI+Fu-lS-DlF-LoKRLoFEKNTNILIPTp-tENpFGFLWlPIVNGssSTSIaLSPsN.ScVsas+I+SllKFIQLCIllu-INsFlolRSIoFDsFKSIosELLGMScRlLsLEsDV+KLKDllsKs...KKKspl-ss-hpusssscscFAsaVaEF.INNNhYIKLSKp-NuLKLs-sPsSoLsVEYDPsoI-HKVGFlFHCRSEISKFssstNhaSINsLlpSFTPNNIsslSQ-sENDLKRKYSLMSSDhScllKssssFlPSNFcRFlsITITNsuYNhN+VFuFcDISsGlSITNLRsIasccScp.cNRYcEYlGcTRlIRAFFhAPCLIQITNlsFso-pLpsD+slsRQIKSIKI+NLSYIPIDIKVGGslIDTIKuspTcsVpINSSEFoFSISCLcIoFSooLISKsKLsNLsTlls-.KYscpTslLpssDKhscLs+sFlscapchN.sLTcLEcaLlupF...tuhcD-ccsEcEcp--DEDpDEsEDE	............pcLlsWppahhaahhlLcpatsscR.p.....ss-IhpthaSschllh+ElFRslhsph........t...DhhchpslFsthsh.........sh.hsLcchhphcKs.psuKlhVsDsDQuIhIlDHhSRlsDpplFsKctlsuaRshEKhlopt.YKlpDhRthGlcWashlscl+otCttpphh.......shac.sDhIuhLohlHslhltpQNc-EpplSthYoLaPFhsLE..............pp...t.pshsspptp+ts.pssp.sssTTpoTTTTTTTs.tshpp+pp.ht..p..............................................h..hsoRcoGuLccVRlssIo.........................sssspp.ssppsIhSlSs+IKshllEsh.sKGElshcsVKulFpsLQsKsYshsLl-slFppNKS-+VITlosphaplssplsa-EI+huclop-lhphu+pl.aEKsTNILlPTps.csthuFLWlPIVsshsSTSlaloP.s.opssasplcuhlKFlpLCIslucIstFls.RSIoa-tFKplsp-L.lsMSpRlLsLEtshcpL+phhppp...+p+ht.pps...p..s.ssp-pchhsalpEF.IssshYIKlS+ppN.sLpLs-sPsSoLslEYsPsoI-HKlGFhaHCRSEISKFsssts.hpIsslhpSFTPsNI+NlS.-pEs-LK+KYuLhsS-hopl.cshs.FhPpsFcRahsIohTNssYNhs+VFuFcDISpGhSITNL+sIatcsopp..ppY.-YhGsTRlI+AFFhAPCLIpIsNhtFsssplhsscslsRpIKSlcI+NhSYlsl-IKVssshlsolKuspTpsV.INSsEFsFSISCLchpFSsoLISKs+Lpplpohhsp.+Ysp.ps.h.phhsphscLhcsFlpphp.hN.plopl-phlhp.a....u.tc-cpsEspc.............-...	0	0	2	2
+1769	PF04562	Dicty_spore_N	Dict_spore_N;	Dictyostelium spore coat protein, N terminus	Kerrison ND	anon	DOMO:DM04424;	Family	The Dictyostelium spore coat is a polarised extracellular matrix composed of glycoproteins and cellulose. Four of the major coat glycoproteins exist as a multi-protein complex within the prespore vesicles before secretion.  Of these, SP96 and SP70 are members of this family. The presence of SP96 and SP70 in the complex is necessary for the cellulose binding activity of the complex, which is in turn necessary for normal spore coat assembly [1]. The function of this region of these proteins is not known.	22.30	22.30	27.90	27.30	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.53	0.71	-3.82	9	43	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	4	0	43	47	0	117.80	32	20.62	CHANGED	h-C-s.hsEspCcus.s.ChhLsasuCCGcpphhCscsstNsChssslSCh+sspospIhEhWSsC.hPpc......sFp.a..PsptoCss...hpCpspGhsCcaspsssChsTSCCPchspChstss	.......h.sCEs..hspspCpsshs..Cpals..ahuCCG.cppthCls.ss..........p...s.....sCp......p..s..s..l...sChps..spsspIaEhWS.s...C.pP.pp......Gap.a..P.sstoCsp...LsCpspG.hsCpas.p........sssC...huTS.CC.sthstCss..s...	0	34	43	43
+1770	PF00186	DHFR_1	DiHfolate_red; 	Dihydrofolate reductase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.07	0.71	-4.65	89	5237	2012-10-03 00:23:32	2003-04-07 12:59:11	14	18	4170	438	1010	3895	1205	156.60	33	84.23	CHANGED	hlslIsAhscNtlIGpssplPW+LPsDLpaFKp..hThG+sllMGRKTa-Sl.s....+..PLPsRpNIVlT.Rs.s..hp.....t.s...s...lhpSlppAl......t.ht....ppt......p-la.lIGGuplYpthls..hA-...clhlTclc..tph.p.GDsaFP.pls..spWphspppttt..spp...sshsasFhtapR	.............................................lshI.s.A.h.....s.....p.....s.....t....lI....G......t......p......s......p......lP..W.....+......L.....P......s....D.....h...t....a.F...Kp...............h.T.............h.............s.................p...........s.......l.......lM.GR+TaE.....S.ls................+...PL.Ps.R...pNlVlo+sss................hps.................p..sst............lhp......S..l-.-...ul..............................t..ht......tp.......pcla.lI...........GGup.l.Yp.ph..l..s.........h....sc.............clal....Tc..Ic.............sph....-.....GD...s....a....F.........P....p...h......s............s......p.......ac...s...t...p...p....h............................tp.......sshsapa.hh.+......................................................	0	312	602	830
+1771	PF02966	DIM1		Mitosis protein DIM1	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.64	20	463	2012-10-03 14:45:55	2003-04-07 12:59:11	11	4	318	9	303	648	68	123.00	59	88.41	CHANGED	hLPHLpoGWcVDQAIloEc-RlVVlRFGR-pDstCMphDElLhpluE+l+NFAsIYLVDlD..cVPDFNpMYELh....DPsTlMFFaRNKHMMsDaGTGNNNKlNaslcDKQEhIDIlEslYRGApKGKGLVlSPhDY	......................................hLPHLpsuWpVDQAIlo.E-..-Rl.VV..............IRFG+...Dh.......D.ss........CM.phDElLhpl.....A-.+.....V.KN.F..AVIY..L..V..DIs..cVPD.FNpMYELY....DPsTVMFFaR.NK.HhM.lD.h.GTG..NN.NK.lNW.shcDKQEhIDIlE........TlYRGA.+KG+GLVlSPKDY.....................................	1	94	161	241
+1772	PF05163	DinB		DinB family	Bateman A	anon	COG2318	Family	DNA damage-inducible (din) genes in Bacillus subtilis are coordinately regulated and together compose a global regulatory network that has been termed the SOS-like or SOB regulon. This family includes DinB from B. subtilis [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.82	0.71	-4.55	14	1291	2012-10-02 14:44:17	2003-04-07 12:59:11	7	1	629	11	408	2210	324	161.30	18	97.05	CHANGED	Msppsh.........phhpa.thsssphhchltsLss-phs...tc.spshholtphLsHlhtschhWlsthph...........ttsph.ppsptcshphhcshppshspthhshhpphs-....ttcphh..s.tsstshphshsplLhHlhsHpsHHRGQlsshlRphGhsss.hshhhh...t................t.ch	..........................................................................................................thhpa..th.s.spp...h.h.p.h.hp.p..L....s..p..c.p..hp............pp.h..s.s.h.h.t.oltcshh...H...lh...s.s.....c.h.h...a..l.s.t.hps.....................................tt....s..h........p...t...h...........p.....p.....s...h....p....p.....l...c...p....h....h..p.....t...h......s.....p...p...hp.....p..a..h.s..p..h..sc.............t..t.h.hhh...........pt.s...s..h....t......s..h...p....h.......s.h...t..p.........h....l...t..H...l.h...s....Hps.HHRGQlss.h...lR.p.hG.h.s.s.s.s.hsh...............tt....................................................................................................	0	165	288	348
+1773	PF00775	Dioxygenase_C	Dioxygenase; 	Dioxygenase	Bateman A	anon	Pfam-B_1018 (release 2.1)	Domain	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.26	0.71	-5.03	20	2905	2012-10-02 19:08:27	2003-04-07 12:59:11	16	16	1090	387	1080	2726	434	159.70	27	65.12	CHANGED	l-GPhYlss...APptss.huchs.t..ss.GpslhlpGpVpDtsGcPlsGApVElWHAsscGhYShasss..ts.paNLR..GpllTDs-GpYchpTlhPusYshPspGsstthlp..hGRHshRPAHlHahVoAPGa.cpLsTQlahpGDsalt.sDhshu.....s+spLlhshpptsss...................................hpchpachsLssp	...............................uPha....t..........................................ts.Gp.l...hlp...GpVh...D......t.....s...G...p...P.l.ss....u..hl-lWpA...su.sG..t....Y.s...t........h...........s..............s........s..................................t.......s........c..................s..........h...c.....................G+h..h..T..D..s...s...G..p..a.p.F..p.....TlhPu..sY.....sh..s........................................t.pshRss....H..lHh...l............u...uh....ptLhT....p....hah..........s..-..hh....ss.h.s......hhttLl.......t...........................................h.........t..................................................................................	0	252	577	855
+1774	PF04444	Dioxygenase_N		Catechol dioxygenase N terminus	Kerrison ND	anon	DOMO:DM04160;	Family	This family consists of the N termini of catechol, chlorocatechol or  hydroxyquinol 1,2-dioxygenase proteins.  This region is always found  adjacent to the dioxygenase domain (Pfam:PF00775).	20.90	20.90	20.90	21.60	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.31	0.72	-4.00	19	910	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	500	43	410	899	78	74.30	31	24.82	CHANGED	ssRs+pIspcllpcLacsIc-hclT.-EahsulsaLschGp.....ptEhsLLussLGlEH..shthDstptps.uhpG..GT	........ssRh+plhppLlpcL+shlc-hclT.sEahtulpaLscsGp...................+pEhhLLuDsLGlpp.....hlDthpttt.................................	1	78	193	315
+1775	PF01866	Diphthamide_syn		Putative diphthamide synthesis protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Swiss:Q16439 is a candidate tumour suppressor gene [1]. DPH2 from yeast Swiss:P32461 [2], which confers resistance to diphtheria toxin has been found to be involved in diphthamide synthesis. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide, a posttranslationally modified histidine residue present in EF2.  The exact function of the members of this family is unknown.	28.70	28.70	29.50	29.10	27.90	28.10	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.11	0.70	-5.18	57	985	2009-01-15 18:05:59	2003-04-07 12:59:11	12	19	467	4	687	991	178	247.50	26	64.82	CHANGED	hPEGLhhhuhpluchL..cp....sst.....sll.GDssYGACsls-hpu.ptlssDhllHaGHosls......ht..h.slal.sph...plDsp.chlcplhpph.......pplullsTlQahptlpplpphLpp.......p...hhlshsps+..htsGpVLGCshssh...........pshlalGsGpFHh.uhhl.u....sph.shthDPa....shshc...p.-tschl+hRhttIp+At..sA..+paGlIluohssQtp.clhcplpphlcp...GhcshllhhsclsPscLtth.s...lDsaVpsACPRlulD.sttFp+Pl.LTPhEhplslstpp.......tpY.hD.h	........................................................hP-tlh..u..lsp.l.....pp..........tt.p.......................hhlhuDs..sY.G.uCClD-hs.A........p........ths.sDhllHa..G+uCL.s........................t.t.l.slalh.sph......t.lc.....ht...thh.p.p.h.pt....t.h......t.t................ppls.lhssh..pa.....t..t...l.pt.h.tt...Ltt...................................t......h.......s......................t..p....l...h...sp...p...............................t.hha.l..us....s..hp......h...............s........hhl.t.....sth.....hh......th....s...Ph...............hp.....h......p....................phtthhthRhth.ltp.........up............p.A..................phhGll.luoLuhps..p.h.hpplp.phl..pt........t...G..h..p............hhlhhucl.s..sKLs.......h.............pl....-saV.luCP..c..h..s....l..........s..............s.....t..F.....+..Pl..loPhEh.lslt.........................................................................................................................................	0	245	397	568
+1776	PF02763	Diphtheria_C		Diphtheria toxin, C domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	N-terminal catalytic (C) domain - blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of EF-2.	25.00	25.00	31.70	106.20	24.10	17.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.23	0.71	-4.85	3	23	2012-10-01 23:25:29	2003-04-07 12:59:11	9	1	10	13	1	35	0	169.70	98	32.48	CHANGED	GADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQACA	.GADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGNYDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKlLALKVDNAETIKKELGLSLTEPLMEQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQuCA	0	0	1	1
+1777	PF01324	Diphtheria_R	Diphtheria_tox; 	Diphtheria toxin, R domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	C-terminal receptor binding (R) domain - binds to cell surface receptor, permitting the toxin to enter the cell by receptor  mediated endocytosis.	25.00	25.00	27.80	81.20	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.82	0.71	-4.66	3	23	2009-09-10 22:55:25	2003-04-07 12:59:11	14	1	10	12	1	20	0	138.70	95	26.57	CHANGED	SPGHKTQPFLHDGYAVSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIK	SPGHKTQPFLHDGYAVSWNTVEDSII+TGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAIDGsVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEIsSDSIGVLGYQKTVDHTKVNSKLSLFhElK	0	0	1	1
+1778	PF02764	Diphtheria_T		Diphtheria toxin, T domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	Central domain of diphtheria toxin is the translocation (T) domain.   pH induced conformational change in this domain triggers insertion  into the endosomal membrane and facilitates the transfer of the  catalytic domain into the cytoplasm.	25.00	25.00	28.40	27.40	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-10.95	0.71	-4.50	3	24	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	11	12	1	32	0	178.30	91	28.97	CHANGED	SCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPA	....................................SCINLDWDsIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTALEHPELSELKTVTGTNsVFAGANYAAWAVNVAQVID.SETADNLEKTTAALSILPGIGSVMGIADGAVHHNTEEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPA.................	0	0	1	1
+1779	PF00200	Disintegrin	disintegrin; 	Disintegrin	Finn RD	anon	Prosite	Domain	\N	19.60	19.60	19.80	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.80	0.72	-11.29	0.72	-3.76	154	2414	2009-09-12 09:20:59	2003-04-07 12:59:11	18	51	294	43	1025	2300	5	73.50	43	11.29	CHANGED	EtGE-CDCGs.cpC..p...ssCC.........sstsC+Lp..sGupC....up.G.CCp..p.Cph..pssGslCRtsp.s-....CDlsEaCsGpSspCPsDhat	.........................EtGE-CD.CG..s.....p.p...C..p........ssCC..................ss..sCp.L...c.........su......u.p......C..............upG.C.C..............c..p..C..p.a......ps.s..Gs.hCRtst...s-.....CDlsEaCsG.p..S..s..pCPssha.h.........................	0	211	280	525
+1780	PF05141	DIT1_PvcA		Pyoverdine/dityrosine biosynthesis protein	Bateman A, Eberhardt R	anon	COG3207	Family	DIT1 is involved in synthesising dityrosine [1]. Dityrosine is a sporulation-specific component of the yeast ascospore wall that is essential for the resistance of the spores to adverse environmental conditions. Pyoverdine biosynthesis protein PvcA is involved in the biosynthesis of pyoverdine, a cyclized isocyano derivative of tyrosine [2,3]. It has a modified Rossmann fold [3].	23.00	23.00	23.70	23.90	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.79	0.70	-5.09	33	360	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	254	4	199	317	7	262.50	32	49.15	CHANGED	plptFlppscPIchlLPAFPsKSP...Np.pKVlGsLPDhuEclALppLsshspcIpplYsPGAclhIsSDG+VFuDlluVsDcslssYspsL+pLhpplu..........hsp.lpahsLpDl........................tth.th.hssphsthRphLhppasssstsl...cpplps...scsththYRGhs+FLh-D....hhs.t.shS+pth+KsspphAhsMIpRupAausLlttpFPptlRLSIHspsssu.KhGIplh...................Pspcsh...hTPWHusssphs....suphhhhp+schtp..shcllphsG	..................................lptalsptp.lchlLPAFPsKSs...N..pKVLGphPDhuEcluLppLsphspcIp.plYs........PGs........p........lhIhSD.G+VFu........Dhl.ul.sDpcl.sYsctL+phhtpht..........hsp.lphhsLpch..........................cphst.h..phstph-thRchLhst.hss.ss....t..l....pppltt...spctthhYpGhp+Fh.pD......h....tt...s.h.S....ppth+.+pspplAhtMlhRu...............pAaushlp......ppFP.ctlRLSIHsp.........sstu.Khulplh..............................sppcsa.....hTPWHssll..s....cGp.hhhhp+pph.p..shp......h...................................................................................	0	23	103	165
+1781	PF04977	DivIC		Septum formation initiator	Bateman A	anon	COG2919	Family	DivIC from B. subtilis is necessary for both vegetative and sporulation septum formation [1]. These proteins are mainly composed of an amino terminal coiled-coil.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.42	0.72	-4.49	70	4922	2012-10-02 13:28:50	2003-04-07 12:59:11	10	6	3891	0	944	2787	1568	78.40	20	63.49	CHANGED	lhshhhhhhhhhttshhshhphcpclsphppphppLppcpppLcsclcpL.p...sp-hlcchARpcLshscssEhhaplspp	..................................hhhhhhhhhhh...h.p...sh.t...ph....h...p.hp....p....p...l...s...p..hpp....php...plp..p...cpppL.......p.......s-lpcL.s..........s.p-...hl.cc.hARpc.huh..s..p..s.s.Ethapl...p....................	0	323	617	794
+1782	PF05103	DivIVA		DivIVA protein	Bateman A	anon	COG3599	Family	The Bacillus subtilis divIVA1 mutation causes misplacement of the septum during cell division, resulting in the formation of small, circular, anucleate mini-cells [1]. Inactivation of divIVA produces a mini-cell phenotype, whereas overproduction of DivIVA results in a filamentation phenotype [1]. These proteins appear to contain coiled-coils.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.60	0.71	-4.10	99	3249	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1865	6	551	1653	105	105.00	27	54.00	CHANGED	lTPhDIppKcF+psh..R.GYcp-EVDcFLDplhcDYEslh...+EspcLccclppLcpclppapphcpslppsllhApphu-chKtsApccuphllppAptpAppllt...........pu.tph.pltpph-.pLK+pspla+ppap	.................hosh-IhpKpF.p...p.th....R...G..YctcEVDpFLD.pl.......hp-a.......-phh.....................pchc....p.......Lc.........p....cl.....p...pLc.......p.......c.......l.............pp..........h.p.........p....................................t....................................................................................................hh.........s..t......t.t...h.....pup.......tstt...........................................................................................................................	0	199	374	482
+1783	PF00778	DIX	DAX; 	DIX domain	Marcu O, SMART	anon	Alignment kindly provided by SMART	Family	The DIX domain is present in Dishevelled and axin [2]. This domain is involved in homo- and hetero-oligomerisation. It is involved in the homo- oligomerisation of mouse axin Swiss:O35625 [3]. The axin DIX domain also interacts with the dishevelled DIX domain [4].  The DIX domain has also been called the DAX domain.	21.40	21.40	21.80	21.60	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.79	0.72	-4.26	25	558	2009-09-11 10:36:07	2003-04-07 12:59:11	12	24	114	18	287	508	1	77.40	42	11.79	CHANGED	sspTKllYa.lscEpsPYhlplstsst.lTLtcFKshl.s+p..sY+aaFKshDsDFu..sVKEElh-DsshL..PsapG+llua...lhss-	.............................s.tphhVhYa..h.....stE.....hPYhspl.ht.s.....lTLucFKphL...s+p..ssY..+aaFKs.....hss-Fs....sVpEE.lh-Ds.shL..PsapG.+lluhl.p..t.........	0	70	98	185
+1784	PF01738	DLH		Dienelactone hydrolase family	Bateman A	anon	Pfam-B_757 (release 4.2)	Domain	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.57	0.70	-5.06	17	4591	2012-10-03 11:45:05	2003-04-07 12:59:11	13	32	2059	10	1757	12590	4895	210.60	23	80.54	CHANGED	hsualutPsss.....hPslllhp-laGls...s.h+thsppLAptG.ahulsPDlYhRpu........................psschspttphhtthhpph..tplhscl........sslsahcups.hpstclGllG.aChGGthuh.hAups..hlcusluaYG........h..sp..lthssplpsPlhhthGppDphlssps...hpplppshttsssshplchYssAuHuFtsstss...........sasstAupcuWp+hhpahpphh	........................................................................................................................................................................sahs.hPttt......t..hP........u.l.l.....l........l........p............-.......h......a........G.lp..............sth.c...p.....h....u....c....c..l....A......t.......t....G....Y..h..s..l.......s........P..D....h...a.tpps.............................................................t.p..h.s.p.t..t...p..h...h...p...t..h...h..t......p...h.................s...p....h..hs.ch..............................s.s.l...s...h..l...t...p.........p.....s.........................s......s....t.+.....l.uhsG.........a.C...........a.G.........G........p....l.........s.........h.........h.........h............A..............s...............p..................s........s.............p............l..........p..............u..........u.........l.........s.........a....YG......................................................p..t...s...h...t.......s...s..p....l.....p....s........P....l....l.h..h..a.u...t..p...D...s...h...h..s...p.t.............h.t.t....h.c.......p............t..L......p.......t.......s....s.......s....p........h.....p...h..h.....h...Y...s...s....s...s.H......u.F.ss..s..tps.............................................pY.s..tt..u.......u..c...p...u.a.pch.ltahpph.h.......................................................................................................................................	0	494	1027	1453
+1785	PF04914	DltD_C		DltD C-terminal region	Kerrison ND	anon	Pfam-B_6216 (release 7.6)	Family	DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.   It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis [1]. This family consists of the C-terminal region of DltD.	23.80	23.80	23.80	24.10	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.60	0.71	-4.28	36	1136	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	1012	6	85	607	7	128.70	41	31.78	CHANGED	pFGIcsp.aYcp+lKp.plp..+LKspp+phsYhp.SPEasDhQLlLsphscppscVlFlIsPVNuKWhcYTGlspchhpphscKI+hQLpsQGFppIsDhSccuscsYFMpDTIHlGW+GWlthDctlpsFhppp	.....................paGIcst.aYpp.plKp.plp..+h.K...spp.c..p...s.Yhp.SPEYsDL.QLlLsph..pcspscslFlhsPVNs.+.WhDYsGlsc-hhptshcKI+.QlpspGa..pIsDhSccsh-tY...Fh...pDTI.HLGW+...GW.lthDctlp.Fhpp.......................................	0	18	38	63
+1786	PF04918	DltD_M	DltD_central; 	DltD central region	Kerrison ND	anon	Pfam-B_6216 (release 7.6)	Family	DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.   It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis [1]. This family consists of the central region of DltD.	20.70	20.70	20.90	20.90	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.91	0.71	-4.05	9	1116	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	994	6	79	595	1	162.20	33	39.87	CHANGED	lGpsGSsSLsHahshsuhhspLKsKKhlaVlSPQWFstpGlspssFpthhSssQlhpahhpps.ssptcphhAKRLLpFp...scsshpphLcplAsspphsstshh.ltp.tp....hhc+p-ulaSphshs.....s.ppplp+hhKtLPcshSappLsplAscpGp+pTssN	.....................LGpuGopSLsphhshpuh.hspLc..sKKsVallSPQWFo.p.pG.hssssFsthaSppQhhpaltpps.ssphc+hhApR...LLph........cs.t...hKph...Lp.plu...p...s....pphs........p...ts....t...thh....th.tp........hLp+p-....s..hhS.Fshc.......s..ptl.p...+h..h..pt....L...s.cphSapp.lcphApppuctpTssN............................................................................................	0	17	35	57
+1787	PF04915	DltD_N		DltD N-terminal region	Kerrison ND	anon	Pfam-B_6216 (release 7.6)	Family	DltD is and integral membrane protein involved in the biosynthesis of D-alanyl-lipoteichoic acid.  This is important in controlling the net ionic charge in lipoteichoic acid (LTA). This family is found in bacteria of the Bacillus/Clostridium group. DltD binds Dcp and ligates it with D-alanine.  DltD does not ligate acyl carrier protein (ACP) with D-alanine.  It also has thioesterase activity for mischarged D-alanyl-acyl carrier protein (ACP). DltD is thought to be responsible for discriminating between Dcp involved in the D-alanylation of LTA, and ACP involved in fatty acid biosynthesis [1]. This family consists of the N-terminal region of DltD.	21.20	21.20	23.00	24.50	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.99	0.72	-4.11	32	1047	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	949	6	72	531	0	62.30	44	15.28	CHANGED	cplcpuAsolossshKGphlKpcAl..ppspYlPhaGSSEhsRhDshHPSVhAc+Ypc.sYpPFL	.........shccuAsShotpshK..uphlps+Al..pss+Y..lPhaGSSEhtRhDshHPulhhcKasc.sa+PFL...	0	12	28	50
+1788	PF03474	DMA		DMRTA motif	Ottolenghi C	anon	Ottolenghi C	Motif	This region is found to the C-terminus of the Pfam:PF00751 [1]. DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown.	20.30	20.30	20.30	25.00	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.66	0.72	-4.10	5	284	2012-10-01 23:03:33	2003-04-07 12:59:11	9	4	122	0	123	261	1	38.10	53	10.22	CHANGED	sRoPIDlLt+lFPp+KRoVLELlL+sC+GDllpAIEshL	......RsPlDlLs+lFPsp+RosLEllLptCsGDlVpAIEplL.....	0	28	39	77
+1789	PF00885	DMRL_synthase		6,7-dimethyl-8-ribityllumazine synthase	Bateman A	anon	Pfam-B_1503 (release 3.0)	Domain	This family includes the beta chain of 6,7-dimethyl-8- ribityllumazine synthase EC:2.5.1.9, an enzyme involved in riboflavin biosynthesis. The family also includes a subfamily of distant archaebacterial proteins that may also have the same function for example Swiss:O28856.	20.60	20.60	21.70	21.20	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.59	0.71	-4.53	104	4443	2009-09-10 17:03:43	2003-04-07 12:59:11	14	14	3970	450	1238	2833	2169	140.60	42	89.31	CHANGED	sssh+lulVsucaNptIscpLlpGAlptlpptG.s..tplslhpVPGAaElPlsspplu.cs.s....c.......aDAllsLG.sVI+GsT.Ha-aVuspsspGlh..pl.....uLcpslPlshGVLTs.csh-QAlcRuuh..ptt...sKGtEAAtAulchlsl...hcpl	.....................u..sh+luIVhuRF..Nph..IsspLLpGAl-sL.p.+.tG...l....p....p....c....sIslshVPGAaElPlsupplA..co..s..........c....................................aDAllsLG.sVIRGsTsHF-YVsspsupGls..pl.....u.l.c.....s.s.l.PV.h.F.G.VLTs.-ohE.Q.A.......lERAGs........KsG.....NKGsEAAhsAlEMhslhct.h....................................	0	390	794	1053
+1790	PF04976	DmsC		DMSO reductase anchor subunit (DmsC)	Bateman A	anon	COG3302	Family	The terminal electron transfer enzyme Me2SO reductase of Escherichia coli is a heterotrimeric enzyme composed of a membrane extrinsic catalytic dimer (DmsAB) and a membrane intrinsic polytopic anchor subunit (DmsC) [1].	19.60	19.60	19.60	19.60	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.70	0.70	-5.14	6	1995	2012-10-01 19:35:38	2003-04-07 12:59:11	7	11	916	0	169	1024	199	261.40	35	93.70	CHANGED	Ms.GhaEhPLVhFTVhuQsslGual...lhullhltucspt..+ph..lltuMFllLsLlGlGFIAShhHLGpPlRAFNuLNRlGuShLSNEIAuGuIFFuluGlaWLlAlltKhssuLuplahllohllGllFsahMspVYp.IcoVPTWaouaTshuFaLThlhuGssLuhuLLpstpls.shshphLshLssLu.................sslsusVslhQGhsLpoIcoSsQpAssLVP-a.........AsLpshRhlLLslshshLlhshhhhc.sslslL.lluhlLlLAGEhIGR...........sLFYGL	....................................................hHEhPLllFTVhuQsslGuhl......V.h..u...l..u..h...h.........t.u..ph.....p.....s.p...................ppt.........lht....s.h.h.h.lh.l..L....h.u..l.....Ghl.AShhHLGpP.......hR..AaNuL..s....+.l.G.uS.hLSNEI....s....u.....u...ol......F......a.A....l.u....Gl....h......a..........L...l..s.........h...........l.......t.....+....h.......s.....s....u....l..t.....p...l.......h.h..l....l.......s.hl...lG...l.l....F...V.a....hMs...pVYp....l.s.TVPTWtss.aTs...hsFa.....lT.....s.h.....l..s...G..s..l...L.u...h.......h......L....l......t.h......u.t.l.......shs....h..p..h...h..s.h.l.s.s.LA..................................lls.ssh..h..........h...h.....p.u....h.p.....l...s...s.....l..c....o....u.l..p...t.u..s.t..L.h..s..s.a.........................................u.tl...sh+...l...l.....L.....l...s..s..uh..s....h...h....l....s..s.......h....t.......t...h...........p.......s....t.......s.s..hL........h...u..h....l.Lllu..GEhlGR...........hlFYs.................................................................................................................................	2	45	97	139
+1791	PF03989	DNA_gyraseA_C		DNA gyrase C-terminal domain, beta-propeller	Yeats C	anon	Yeats C	Repeat	This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a  beta-propeller structure [1]. This region has been shown to bind DNA non-specifically and may stabilise the DNA-topoisomerase complex [2].	20.40	4.10	20.40	4.70	20.30	-999999.99	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.96	0.72	-4.66	362	37895	2009-01-15 18:05:59	2003-04-07 12:59:11	8	34	4630	51	7547	27731	14770	47.70	22	27.63	CHANGED	cp..llhhTppGhsh+hsh................................................schpt..hsRsspGlpsh........plpcs..-plhshhhss	...................................................................................llhhTppG.h.sh..R.h..sh..............................................................................................................schpt.....hs.R.s.sp.G...l.psh...............plp..cs.....-plhsh....t.............................................................	0	2464	4959	6375
+1792	PF00204	DNA_gyraseB	DNA_topoisoII; 	DNA gyrase B	Finn RD, Griffiths-Jones SR	anon	SCOP	Domain	This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold.  This family is structurally related to PF01119.	20.70	20.70	20.70	20.70	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.15	0.71	-5.05	99	18153	2009-01-15 18:05:59	2003-04-07 12:59:11	20	41	10023	20	2024	14069	4290	160.20	42	30.69	CHANGED	Glpcalchhsps.........................h.hpstt..............ps....hpl-lAhtas.s..s.s...c.plhSFs..NsIsThcGGTHlsGhcsuls+slspascpp.phh......ppt.t....plsscDl+cGLssll.sl....+lssP..pF-GQTKp+Lssspsp..shlpph..lp-pht.phlp..css....phscpllppshtttc....sRhs..s+ps+ch	................................................................................GlpsFVcaLNps....K...psl.............hsp..........lhhhps-p..................................cs........lsVElA.hQWN..-....uap.......E..slhsFs...NNIsp+-GGTHlsG.FR..sALT.......Rs.lNs.Yhc...cp...shh...............Kc...t.c......sloG.-DhRE.G.LsAVl.SV....K.ls-P......pFp.uQ.........TK.sKLssoEs+.................shVp.p.h.hs-...tls.paL.....cNP................p..A+hllpKhlpAAp...........AR.A....A++AR-........................................................	0	674	1283	1691
+1793	PF00986	DNA_gyraseB_C		DNA gyrase B subunit, carboxyl terminus	Finn RD, Bateman A	anon	Pfam-B_332 (release 3.0)	Family	The amino terminus of eukaryotic and prokaryotic DNA topoisomerase II are similar, but they have a different carboxyl terminus. The amino-terminal portion of the DNA gyrase B  protein is thought to catalyse the ATP-dependent super-coiling of  DNA. See Pfam:PF00204. The carboxyl-terminal end supports the  complexation with the DNA gyrase A protein and the ATP-independent  relaxation. This family also contains Topoisomerase IV. This is a bacterial enzyme that is closely related to DNA gyrase, [1].	21.10	21.10	21.10	22.00	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.08	0.72	-4.22	72	9044	2009-01-15 18:05:59	2003-04-07 12:59:11	16	17	5005	38	1681	6230	3303	62.90	53	9.63	CHANGED	ttppphpIQRaKGLGEMsscQLWETTMsPcsRpLlpVplc..D....ttp..scchhshLMGc.cspsR+paIp	................s..ppthslQRYKGLGEMNs-QLWETTM.......cPcsR..pLlpVs..l..-....D....................uhp........A-ph..hshLMG-.cVEsRRpFIp.........	0	548	1095	1410
+1794	PF03603	DNA_III_psi		DNA polymerase III psi subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.20	20.20	20.30	20.80	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.70	0.71	-4.28	26	745	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	743	5	76	295	13	127.30	54	93.11	CHANGED	M.s+RDhhLQphGIoQWpL++PphLp..G..phslsLsscsRLllVusphPptsps.LlpDlL+SlpLs.sQshplss-plshLstpph.phhWhlGscpsth.htu...........tpL........pSPtLspLpssspsKRsLWQQIssa	............MTSRRDW.LQQLGITQWsLRRP...u.ALQG.............EIAIul.PsHVRLlhVAs-LP.uLs-P..LlpDVLRALsloPD..QVLpLTPE+lAML..Pp..so+..CNSW.RLGsD....pPLs....LcG...........AQl..............sSPAL.s-LcuNssARtALWQQICsa........	0	6	25	53
+1795	PF01653	DNA_ligase_aden	DNA_ligase_N; 	NAD-dependent DNA ligase adenylation domain	Bateman A	anon	Pfam-B_1334 (release 4.1)	Domain	DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor [1]. This domain is the catalytic adenylation domain.  The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism [1].	19.00	19.00	19.00	19.00	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.85	0.70	-5.48	15	5286	2012-10-02 00:43:09	2003-04-07 12:59:11	13	57	4462	24	1089	4137	3767	299.60	38	46.15	CHANGED	ppsppclpcLpchl+pasYcYYVhDsPhlsDu-YDpLhpcLppLEpcaPELlTPDSPTQ+VGuussputFpplpH.sPMLSLDNAFspc-LpsahcR....lpcthsppsp....aslE.KIDGluluLhYcsGlLs+AsTRGDGphGEDVTpNl+TI+sIPlplshs.......tplElRGEVahsKcsFtpLNpph.cpsccsFANPRNAAAGSLRQLDPclTA+RsLphhsYulu..ps.phshpTQhtsLphL+phGFs.Vspphphsc...sh--VlsahcpapccRcsLsa-IDGlVlKlsplshQccLGaTu+uPRWAlAYKFPAc	...........................................................................t...ppchpcLppplppash.tYY..s...D....s....P..plsDuEYD.pL.h.c.cLtpLEppa....P.......-....h................h.s.......s.D.....S............P....T.p...RVGh...s.....s.l...........p.u.........F.......pplpHthPML..SL..s..s.....s......F..........s..........c.............c.........-..l..p..sF.pR......................lp...c........t...l..........s......p......s....p.............ahsE.KlDGLAloL..hY....c.....s......G.......h.............Llpus.TRG.D.G.p.tGEDlT...p..N.l.........+T..I......c..s....I.Ph.pLptt................................PtplEVRGElahs+psFtpl.N..............tpt.t......p...............p......G............p..........p...............h.....F......A.NPRNAAAGSL..RQ.....L..............D...s......p........l.........o.........A..........p...........R.........s........LshFsYu.....l..............u..................................p...................s...........................................t........................s......o..............p...pt....Lp.hL..p.p.......hGF.........s.s....s....s.t....h....p....h....s.p......................s..h..--.....l..h.p.....ah....pch..............t........p......p...........R......s...........s..L.......sa-I..DGlVlK.VsclshQc.pLG..a........s........u.+.....u.PRWAlAaKFPAp.....................................................................................	0	368	717	925
+1796	PF03120	DNA_ligase_OB		NAD-dependent DNA ligase OB-fold domain	Bateman A	anon	Pfam-B_1334 (release 4.1)	Domain	DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor [1]. This family is a small domain found after the adenylation domain Pfam:PF01653 in NAD dependent ligases [1]. OB-fold domains generally are involved in nucleic acid binding. 	25.00	25.00	27.00	25.40	24.30	23.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.55	0.72	-4.32	23	5111	2012-10-03 20:18:02	2003-04-07 12:59:11	11	59	4425	11	1047	3928	2199	82.00	46	12.29	CHANGED	s.TpLhDlplpVGRTGs.lTPlApL-PVpluGosVopATLHNtDhIcc+DIRIGDpVllcKAG-VIPcllpVlh..-pRssssps	............t.hTplpslchpV.GRTGs.lTPVApL.............c......P.......Vpl.....uGssV....opATLHNhDp.I...........c............c............h...........Dl.+..l......G.DpVl.lp+AGDlIPcllpVlh..pcRstpt.............	0	351	681	885
+1797	PF03119	DNA_ligase_ZBD		NAD-dependent DNA ligase C4 zinc finger domain	Bateman A	anon	Pfam-B_1334 (release 4.1)	Domain	DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilising either ATP or NAD(+) as a cofactor [1]. This family is a small zinc binding motif that is presumably DNA binding [1]. IT is found only in NAD dependent DNA ligases [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.44	0.72	-4.24	152	3952	2009-01-15 18:05:59	2003-04-07 12:59:11	11	37	3909	5	869	3009	904	27.80	47	4.05	CHANGED	pCPsCsotlh.+.ps.....Es.shRCsNs..sCPA	...pCPsCGSclh.+hEG............Es.shRCsss..hCsA..	0	296	579	741
+1798	PF00145	DNA_methylase		C-5 cytosine-specific DNA methylase	Sonnhammer ELL	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.04	0.70	-5.32	31	7421	2012-10-10 17:06:42	2003-04-07 12:59:11	12	102	3000	52	1976	6841	2919	257.40	19	65.39	CHANGED	hchl-LFAGlGGhcLGhcpsu...........hpslhusEhDcp.....AhcoYptNa......phshsDIsphshp....plP.....hDlLluGhPCQsFShAGp....ppGhsDsRG...sLFa-hhRllcppc....PKhFlhENV+sLlspcpt...pshpsllpphcchG..YpVp.......hplLsApDaG.lPQsRcRlallGhcpch.........................th.phphsp.....................h.sltDlhpp.........h.pschshssphhpshphht....t..tsas..........hhhpp........................................cphttsthhshshpppsh..................................h.tsshhtpsst.......................................pthRplTsREsA.RlQGFP-s.....Fphhssps........ptY+phGNuVsVsllptlucplhp	...................................................................................................................................................................................................................................hphFsG.h..G....uh.p.h....u....hpt.hs................................hph..h.h..h.-..h...p.................................sh.t.s...ht...h...ph...................................t..D......l...t...ht.t..........................................th.....t.....h-....l.l.h.u..G.PC.Qsa...S....h....h....s...............................t...t....s......h........t.......p....t..p.s.......................tL....h..h...p..h.h....c....h....l.....p...........h...p...................P.t......h....h.h.h.E..NV.....s......h...........h.............p...................................................h..t....h...h...t.....h...............t..........t..............h...s.........Y.t.h....................................h..l..p...s.t.....p..a.......t......hs...ptRpRh...h...hl...uh.....t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................R...ho..hE...........hh.hh...s...h...t............................a..........h........................................h..hGsuhs..h...hh.....h...........................................................................................................................................................................................................................	0	634	1210	1611
+1799	PF01119	DNA_mis_repair		DNA mismatch repair protein, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	SCOP	Family	This family represents the C-terminal domain of the  mutL/hexB/PMS1 family.  This domain has a ribosomal S5  domain 2-like fold.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.26	0.71	-4.64	151	4737	2012-10-03 01:04:38	2003-04-07 12:59:11	14	30	3934	16	1407	3880	762	118.40	30	17.88	CHANGED	ltsl..hGpshspph.l.lp.tpsps........hplpGalupP.s.....hsRus.psh.hhalNGRhl+sp.....hlpcAlcpAYp.....shLsts+aPhshLhlclsPptVDVNVHPsKpEVRFpcpctlhchlhpulppsLt	..................................................................tslhGhth.h.pph..ltlc...hppts...................hplpGalu.p..P..p.............................hs.Rus....ps..hphhal..N........G...........Rh..l.+.s.p.............hls+....A....l.p...p....uYp.............................sh...L...s....t.s......p..........a..........Phhl..L.hlc......l.D..P.p.t.VDVNVHPs.KpEVRFpppc..tlhphlhpulppsL.t.........................................................	0	473	844	1161
+1800	PF02499	DNA_pack_C		Probable DNA packing protein, C-terminus	Mian N, Bateman A	anon	Pfam-B_1283 (release 5.4)	Family	This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is found at the C-terminus of the protein.	19.60	19.60	19.90	19.60	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.31	0.70	-5.71	27	252	2012-10-05 12:31:08	2003-04-07 12:59:11	10	4	127	9	1	214	0	256.60	42	58.45	CHANGED	LsQsssKIIFlSSoNoucpSTSFLaNL+sus-chLNVVoYVC--HhpchstpsssTuCsCYhLpKPsFIThDsslRpTAsLFLtsuFhpElhGs...tssst.sssptllo-pAhspF.lhRsSTssppsh..LspsLaVYlDPAaTsNscASGTGlAsluph...psphllhGlEHFFL+sLTGouutpIApCssphltulhsLHP.hhppV+lAVEGNSSQDSAVAIAshlpc.h.............shslhFaHstsp..sssltaPaYLLs+pKohAFEhFIttFNSGplhASQ-lVSpTl+LohDPV-YLlcQl+Nlpplshps....sstoYouK..p.pshSDDlLVAllMAhYlus...ssptsF+sl	......................................h.QtssKlIFlSSsNoucpoTSF..LhpL+sAs.p..c.hLNVV..oY..VC--Hhpchst..+ssu..suCsCYpLaKPsFIoh-ssl+cTANhF.l..tsuFhpEIhGs....sspt...s..........psp.llocsuhpcF............lhR.STsspp..sh..hutsLaVYlDPAaTsNt.pA.......SG....TGluhlsth........p.llhuh-ch.ltth.t.s....t.hh...h......a.....h.....h.h....p................................................................................................................................................................................................................................	1	1	1	1
+1801	PF02500	DNA_pack_N		Probable DNA packing protein, N-terminus 	Mian N, Bateman A	anon	Pfam-B_1179 (release 5.4)	Family	This family includes proteins that are probably involved in DNA packing in herpesvirus. This domain is normally found at the N-terminus of the protein.	20.30	20.30	22.70	24.70	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.85	0.70	-4.87	26	149	2012-10-05 12:31:08	2003-04-07 12:59:11	10	3	92	0	1	142	0	267.60	39	43.48	CHANGED	R.cphshPhlGslHusspaushhpshspphh.........t.t...s.........ptt....sspshlss........pLpsslppLpFhphs.tpstspcstYpushsoapuhhpsssFppLpsFltshuphLsssapst.................................pupLE.FQK.llMHshYFlsSlphs-psc+h.hshl+hhFslsphossslcpFKQ+AoVFLVPRRHGKTWhlVslIulLLuohcsI+IGYsAH.++sopsVFpEIhspLp+WFsscpl-hhKsp.TIsFsasstppSTlhFASsaNTN.SIRG	.........................................................cRaQhshPtlGhlHsss-hs..htuhspchh............................s..tppp.hlts........pLppslppLpFt..s..psttp+ssYpsshsshpshhcsstFpQlssFlpcFsphLssuFpst............................tctc............................................................pspLE.FQK.lLhHsha.Fluu.spls-hA.p+l.hpaLptsFslshhS....pssl....c....pFKQ+ATVFLVPRRHGKTWFlVPlIuhlLss..h..pGIpIGYsAH.++sopsVFcElctpl++hFssphVscsKsp.sIohsasstu+SThlFASsaNTN.uIRG.....................	0	1	1	1
+1802	PF00712	DNA_pol3_beta		DNA polymerase III beta subunit, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_631 (release 2.1)	Domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.27	0.71	-10.21	0.71	-4.21	15	4817	2012-10-02 11:47:48	2003-04-07 12:59:11	14	8	4456	54	1006	4270	2846	120.10	28	32.57	CHANGED	MKFsIpR-pLlcsLppVu+slssRsolPlLuslLLpsp-..spLolTuoDhElphpuplstpps.......ppsGslslsuRhlhDIsRsLPs.pplplphss..s+hhlp.uGp.......S+FsLsTLsu--aP..sLs	...................................M+Fsl.p.+stLlp...sLpplppsl...s.s..+....s.o..l....P.I.Lu.slhlp....s..p..s........sp.lsLouoD.h......-...l.p..l..p..s..p..l..s..h..p..ts........................psG...s.....h..s....l.sA+...hhh-...Il+...p..L....P.....c.......t..p...l.s..l...p..h..c..s........pp..h..h.lp..uG+....................Sc..FsL.ss.l.s..us-aP.pl............................................	0	348	678	861
+1803	PF02767	DNA_pol3_beta_2		DNA polymerase III beta subunit, central domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_631 (release 2.1)	Domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.22	0.71	-4.06	15	4914	2012-10-02 11:47:48	2003-04-07 12:59:11	11	14	4454	54	1035	3844	2795	115.90	30	31.47	CHANGED	slssssL+clIppTtFAhupp-sR.hLsGlplchpss....pLhhsATDuHRLAlpchphspstss..hsVIVPsKslhELs+llss...sp.lpltlu.......ssplthcssshhhTS+LlDGcaPD	............................lstphL+chI.p.p.T..t.FA...h..u...p.p...-..s.R......h.LsG.....lhh...c...l....p...ss..........pL.p.sVA..TD......u.....H....RL.A.........h........p.p............h.............p............l.............p.....p............s.........h......s.......................p...............h......slIl.P...t.KultE...lt..+.l.l..ss.......sp..p..s..l.p.l.t.lu..................s.s..p...l.h.h........p..........s...........s....s...........h....h....h.h.S.+.L..l.-.G.p.aPD..................................................................	0	353	699	887
+1804	PF02768	DNA_pol3_beta_3		DNA polymerase III beta subunit, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_631 (release 2.1)	Domain	A dimer of the beta subunit of DNA polymerase beta forms a ring which encircles duplex DNA.  Each monomer contains three domains of identical topology and DNA clamp fold.	20.30	20.30	20.40	20.30	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.23	0.71	-4.54	16	4819	2012-10-02 11:47:48	2003-04-07 12:59:11	10	13	4457	54	1006	3167	2433	121.10	27	32.84	CHANGED	ppllPpchsphlslssp.LtcAlpRsulLup.-+spsl+Lpls..sspLclsusssEhGpucE..tlcsshh..GcslpIuFNspYLLDsLsslcspclplphsssspshllpsssssssp.llhPh+	......................................+llPp.s....s..p..plp.h.spppLhpAlcR.su.ll.....op....p...+..t......p..s...V...+L..p.l.s........p.s.pl.....p...l....ou.s....s....s.-.......u........c.u.pE.............pl...s.s......shs..........G.c.....s...l.c...I...u..F..Ns..pY..llD...sLps..l.....c...s.-...p.....l.plp.......h.......s.s.......s.........s......ps...s......l......l......p........s......s......s......s......p......s.....h...h...h..l..lhPhp......................................	0	348	678	861
+1805	PF04364	DNA_pol3_chi		DNA polymerase III chi subunit, HolC	Kerrison ND	anon	COG2927	Family	The DNA polymerase III holoenzyme (EC:2.7.7.7) is the polymerase responsible for the replication of the Escherichia coli chromosome.  The holoenzyme is composed of the DNA polymerase III core, the sliding clamp, and the DnaX clamp loading complex. The DnaX complex contains either either the tau or gamma product of gene dnax, complexed to delta.delta' and to chi psi. Chi forms a 1:1 heterodimer with psi.\	The chi psi complex functions by increasing the affinity of tau and gamma for delta.delta' allowing a functional clamp-loading complex to form at physiological subunit concentrations.  Psi is responsible for the interaction with DnaX (gamma/tau), but psi is insoluble unless it is in a complex with chi [1].	21.40	21.40	22.40	22.30	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.78	0.71	-4.34	151	1629	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1600	3	343	975	388	138.40	35	93.69	CHANGED	M..sclhFYhLspssh..........tphhspLhpKuhppGh+.lhltspsppptptLDchLWsass-uFlPHsh..ssps...sst...p.PlhLsh.stt..sss..ts..lLlsL.sssh..Ps.hspF.pRll-lhsss-s.thptARp+a+ta+.st...Ghslph	.........................MppssFYlLssssh.......................pphlCcLst...ctac.p..G.....p.....R.VlltspDc.ppAtpLD-tLWsh.ss-uFlPHsl.....sG..Eu........sp..ss................s....PV.luhspp....t...........sss.+s..........lLI..sL.pssh........ssh....s..ssF..scVl-hVsh--s.h+phA.R-RaKtYR.st....GasLsh.............................	0	79	183	259
+1807	PF00476	DNA_pol_A		DNA polymerase family A	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Family	\N	23.80	23.80	23.90	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.15	0.70	-5.84	12	6834	2009-01-15 18:05:59	2003-04-07 12:59:11	15	51	4984	160	1526	5654	5505	340.20	33	42.62	CHANGED	lchchhpthspchshp.htthttphhchuGppFNlsSscQLphlLF-chGl..hthTcp..Gs.oTssssL-pLt...sc.hlphllpa....Rpls+LpsTalctL.phlsstsG+lHTpaspssTtTGRLSSssPNLQsIPh+s......c.GpcIRpuFlAp.G..hslluuDYSQlELRlhAclusDpthlpsFppGtDlHphsAuchaGlshcs....VsuppR+sAKshNFGllYGhSAhtLuppLs.....IopcEApchh-tYFtpaPG..................................lcpahcchhc...........cu+ppGYlpTLhsRRc......lPclsSp....stshcptAERh......AlNhPlQGoAADlhKhAhIplc.hLpc.t.ps......RhhlpVHDEllh-ssp--..httlsthlpplMcpshth........pVPLhs-hshG.tsWhsA	.......................................................................................................................................................h.....h.t.ttpht.t..h....tth.ttp....h.h.t....h..s...G..p..t.F.N.l.s...SsK.Ql.t....l.....L..F..c..c.......h....t..l......................................h......t......p......p........p...................t....................o......T..s.....t....pl.....L..p......pL....t..........................t..........h.....s......l..........t.hlLpa........................Rtl.s.K...L..p.o....T............a....s....c..t....L.....................t......h......l....p........................p..............s.......u............R...l.H...o.p.....a..............Q............s...........h.........s.t.TGR.L.S.S...s.s....PN.....LQ..N..IP..h+s.................................p.G+.....c....I.....RpuF...l.....s........s.........pG...........hhl..l..u..ADYSQIELR.lhA....H.....l....op..D.p........t.......l.......l...p..........A.......F.......p........p............G...........t.......D...........l...H..p..tT..A.....uc.l..F..s....l.s.h..cp...............................ls..s...p.p....R+.p.A.Ks.lN..FGl.......l...Y..Gh..o..sa......uL......u..p......p..Ls...............................................ls.c..p.-.....A....p....p.....hhc....pYappaPu.......................................................................................lppa..h..cp.h.hp...........................................pA.c..p...p..G..Yl..p........T.....lh..s.RRt.....................................hl.....P.c..l..p.up......................sh..h+t..h..u.E..Rt................................................AlNsPlQ.G.oAA.DIl.......KhA.M...lp...l...p.p..h.l......p..p.....t...t....h..ps....................................+..hlh....Q...VHDELlhEl....p....pc....hpth.....tt..h.l...t..p...hM....p.p.....s....h.p.h.................................pVP..Lh...sc.h.t..G.tsW.p............................................................................................................................	0	539	976	1295
+1809	PF03175	DNA_pol_B_2		DNA polymerase type B, organellar and viral	Mifsud W	anon	Pfam-B_236 (release 6.5)	Family	Like Pfam:PF00136, members of this family are also DNA polymerase type B proteins. Those included here are found in plant and fungal mitochondria, and in viruses.	22.90	22.90	22.90	22.90	22.80	22.70	hmmbuild  -o /dev/null HMM SEED	459	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.55	0.70	-5.82	35	975	2012-10-02 01:06:00	2003-04-07 12:59:11	8	18	262	25	572	970	44	307.10	22	53.07	CHANGED	chs.....cshhhhstplhh.DhsFhLsphppht..............hhphthhppshhpphchphphhphhltDoatlhh.sSLccsupuasl............hpKGhhPYctlsp.h....h.....ttshPhhcYhcc.phhhhpcplhp.hc...s.taclhccslcYsphDlhlht....plhtpapphlpcphsl.psshphap...luu.ohtIF+phh...............................................................phsstlhsPs.cchaphlRpulhGGRs.sph.shhp.....lahYDlsShYPuAhp.ashPhGpPhtstt.pththpch.htlpp....lphhspphpshl.....hlsh+sssphh.....hsshsshsu.....hhaosE-Lchtlspu......hhcshhlcsh..ccpsslFs-ah...ccahplphsucppuccpp......luKlL.N.uLYG+Fupp.....spchhlhs-ph........-ptphppltssphhlpppthhps.......pshssphh.tsstshshtp..htphspsttst.pphthtsttsh	...........................................................................................................................................................................................................................................h.hp.h.hh....l..h...h...t.................................h.h........................................................................................................................................ta..ch.c....t.h.....YCt.DVhlht...............chh.p.a..tp..hh..pthp...l....th..h........lsS.u...t..lFcphh....................................................................................................................................................s.t.lht.s...pp.hp.....a...l....p..p...sl.GGR...s..........................h.....h.....p.......p.lh...aDh..s..uh...Ys..SA.ls...h..h....G..Phs.h........................t..........................hh.......................h.h................h...........................................................h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	439	448	571
+1810	PF04042	DNA_pol_E_B		DNA polymerase alpha/epsilon subunit B	Wood V, Finn RD, Bateman A	anon	Pfam-B_12632 (release 7.3) and Pfam-B_5821 (release 7.3)	Family	This family contains a number of DNA polymerase subunits.\	     The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner.  DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast.  The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18.  Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure [1].	20.50	20.50	20.70	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.41	0.70	-5.08	34	1130	2012-10-02 19:15:56	2003-04-07 12:59:11	11	22	407	8	787	1175	118	215.10	19	39.82	CHANGED	llhsSGlhhs...tsshs....hchLpchlptht..........ss.sstlllhGshlstptt.ht.t.......................shstshhhltplpshlppls....tssplsllPuspDssst........hLPQtPh.pt.hhsc.pth............................hphsoNPsphpls..shplsssss-hltclt+tphtpss............................................................................hchlcplLpppplsPhsP..................................shhshsatpppshhl.ps..hPclhlsus...ttpFsp	.................................................................................hhlhSslhhs......s.shs...............hphLt...chl.ptht........................ssts.s..h.lll.hGs.hlsts..t..h.h.tttth............................................sh.p...p...h....th....h....t......p....l.ts.h...h.tplh............tshp.llllP.G.s.pD....ssst..........shP...Q.s..l.pt....hh.s.ph.pph..................................................hphsoNPsphpls...................sh.pl...hhsp...schlpclt.+.t..p..h.t.t.s.t..................................................................................................................................p...tc.l.h.cplLpppphsPhhs...........................................................................sh.h.sh..sa...p....h...p...s..s...h...hl....s..........hP...clhhhss......F..............................................................	0	269	448	662
+1811	PF04931	DNA_pol_phi	DNA_pol_V; 	DNA polymerase phi	Wood V, Bateman A	anon	Pfam-B_10566 (release 7.6)	Family	This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localised exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.	22.00	22.00	22.20	22.00	21.30	21.90	hmmbuild  -o /dev/null HMM SEED	784	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.21	0.70	-6.76	5	422	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	249	0	305	433	5	450.40	15	60.45	CHANGED	huYlLcRLI+GLuSsRpuARssauluLsplLstsp-IsssclL-tLc+csshsusp+uh-cssla.h...usLlsshsullhupll+cKsplsEslFppltlLhlhpuptsaLpusslplIsctLccsshpp.sh.sLhshlsKlLps.hcVs.oS-clLula.Lshs+VhsNccSp..sVthhsp-shcsLhclh.lsusolppcpscsclAusLlpLsKs..Klsusap.lspcthhKpsutcusshssphlslssslhssEphthlcpsspppptlp+sssS+spsshcFhcphppslspthpsEccsspRhhhphhshltsscppssshsshsphhplhppLsopshss.loss+cspplh.pssVcoltchsshppshlpssstplscuolss-ppp+htpsphlhllcpthppKptshlcph..FplapsactsKssTst..AlsstFS...EsssptlclsthsuLhhspSsthpQs.s.tp.GchtLspLtplsphpLp+pLscsstpup.csshscppppsasplcppL+pcsupsu-spspAFcpLlllVsLplhspss-S........s-VLpDlpsChcKuhscssp....tp.+EpsscEPssM-VLTElLLSLLuQsSsLhRclVchVFspFsp-lsp-uLpllL-VLKtc.shscpsth.tGEEE.EDsh..oDsDED-pcsl-DuEsESE-........DsEssEsDEp-DDuEusptlh.hc.ulcppLscsLp.sssl.................cGu-S-DEEsMDDEpMhcLDspLA...plF+E+Kc...+hQuscEcKppsQps+ppllpFKlRVLDLLElYl	.................................................................................................................................................................................................................t........h..........l..hh...............h...............................................................h.......t.........h....t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..............................................................................................................................t.....t................hhh-hhlthh.p......t.....t.....h+t....hh...h.......................ht.tth..hht........h.........................t......................................................t................................................t.........p...............t....t............................p.......t..t....t.....t.t.t............................t........t.t....t................t.....t....................................................................................................................t.t......p.............t.......h.s...-tt......h.t..h...s..l....thh..............................................p.+hhthh........................................................................................................................................................................................................................	0	105	176	258
+1812	PF00336	DNA_pol_viral_C		DNA polymerase (viral) C-terminal domain	Finn RD	anon	Pfam-B_107 (release 1.0)	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.66	0.70	-5.11	3	8753	2009-09-12 08:13:51	2003-04-07 12:59:11	13	16	93	0	1	8052	1	158.20	90	27.33	CHANGED	GSYGSLPQDHIlcKIucCFRKLPVNRPIDWKVCQRIVGLLGFVAPFTQCGYAALMPLYsCIQS+QAFTFSLlYKoFLpcQYhcLYPVARQRuGlCQVFADATPTGWGLVhGsQRMRGTFuuPLPIHTAELLAACFARCWSGA+LLGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGpLGLLRPLPRLhFRPSTGRTSLYAsSPPVPsHRPsRVtFASPLQss-AWRPP	.........GSWGTLPQEHIVQKIKpCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQuKQAFTFSPTYKAFLsKQYLNLYPV.A...RQ.................................................................................................................................................................................................	0	0	0	1
+1813	PF00242	DNA_pol_viral_N		DNA polymerase (viral) N-terminal domain	Finn RD	anon	Pfam-B_107 (release 1.0)	Family	\N	29.90	29.90	30.00	30.80	29.00	29.80	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.30	0.70	-5.43	15	5612	2009-01-15 18:05:59	2003-04-07 12:59:11	12	21	92	0	0	5444	0	301.90	78	41.87	CHANGED	MPL..............SYpHFR+LLL.....L-E..Eu.....GPLE-tLPRLADEsLN+RV.........AEsLNLth.sVsIPWTHKVGsFTGLYSopsssFNPcWpTPsFPcIHL+pDlIs+CppasGPLTlNEKRRLKLlhPARFaPpuTKYhPL-KGIKPaYP-aVlsHYFpTpHYLHTLWcAGILYKREoo+SASFpGoPYSWEQc..LQHGs..h.pt..t.t.cshsuQSutILuRu..........................ssGsshQuphppSRLGhpup...pGplApuppGpShulRuRs+uospRshusEsSuSspssppA.ScSuSshpQSusRcsAaophSTocRpSSS....upul-hpslPssospupspuslh.ChWhpFRsS.+PCSsYCLsHlVsLL-DWGPC	.......................MPLSYQHFR+LLL.....LD-EA.....GPLEEELPRLADEsLNRRV.........AEDLNLG.NLNV.SIPWTHKVGNFTGLYSSTVPlFNPcWpTPSFPpIHLppDIIs+CpQaVGPLTVNEKRRLKLIMPARFYPshTKYLPLDKGIKPYYPEpsVNHYFpTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQE...LQHGp..h.psspR+G-ESFssQSSGILSRu.................................sVGss...lpSph+pSRLGLQsp...QGpLAptppGRSGSIRARlH..PosRRsFGV.EPSGSGHhsNpA.SsSSSCLHQSAV.RKsAYS.pl.ST.SK+p..S..SS....GHAVE.LHslPPsSARSQSpGPVhSCWWLQFRNS.KPCS-YCLoHIVNLLEDWGPC................................	0	0	0	0
+1814	PF04104	DNA_primase_lrg		Eukaryotic and archaeal DNA primase, large subunit	Kerrison ND, Finn RD	anon	COG2219	Family	DNA primase is the polymerase that synthesises small RNA primers for the Okazaki fragments made during discontinuous DNA replication.  DNA primase is a heterodimer of two subunits, the small subunit Pri1 (48 kDa in yeast), and the large subunit Pri2 (58 kDa in the yeast S. cerevisiae) [1].  The large subunit of DNA primase forms interactions with the small subunit and the structure implicates that it is not directly involved in catalysis, but plays roles in correctly positioning the primase/DNA complex, and in the transfer of RNA to DNA polymerase [4].	21.10	21.10	21.60	22.60	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.94	0.70	-5.12	48	540	2012-10-01 20:20:07	2003-04-07 12:59:11	9	10	444	11	383	545	79	237.20	27	54.76	CHANGED	pha+lsapshh.cLsp..p+........phhlc.pGhsalstpphhsllhppappplpc..slthhtpshs..cl....pcct+..lt.hhppls................................ttht.tp..h.splstppFP.CM+plhppL...ppsp+LcHtuRhplshFL+.......................slGlsh......--slphacpth..........s.scFsc.php..YsI+HthG...........-Gppss.....YsPhs.....Cpplh.............csaG...CPh...........s.-pL..................................................................................sppttl.pHP.pYa	..........................................................................acl.satch...cLsp....pR................phhlppG..hsals....t...pp....hh.....sllhppappplpcslthstpths....pl....ppcp+..ltsl..lppls...h...t.............................tstl.shpp....l..spl.s.pp..FP.CM+plhptL...cpspHL+HtuRhQhslFLK............................uIGlsl..............--sltaa+pt.att.............hs.-cFs+...pap..YslR.HtaG.............cGpcss.....Y.sPho.....Ctplh.....t....s.t..........ctHG...CPa+p..........s.ctL.t.l..............................h.t.................lh....t.p...phuC..hh...p........................s....l...HP..aa...........................................................	0	138	224	321
+1815	PF01896	DNA_primase_S		Eukaryotic and archaeal DNA primase small subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	DNA primase synthesises the RNA primers for the Okazaki fragments in lagging strand DNA synthesis. DNA primase is a heterodimer of large and small subunits.  This family also includes baculovirus late expression factor 1 or LEF-1 proteins. Baculovirus LEF-1 is a DNA primase enzyme [1].  Bacterial DNA primase adopts a different fold to archaeal and eukaryotic primases.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.98	0.71	-4.39	73	1657	2012-10-02 15:26:12	2003-04-07 12:59:11	14	27	1225	21	676	1488	174	154.80	19	29.20	CHANGED	FDlDhschsshcs...............h.hhh.hhhhshthh.tsltc-hu.hpp..............hhhhhSG.........p+GhHlal.....s.ppshphsshpph....h.................................................tpthsptlhpppshhhst.................................................................................h.h.hlDhplspphpp......hl+sPhsh.......cstssplsss............................lsh	..............................................................DlD.........t.............................................h...t.s.t..h.hptl..h...c-hGhps...............h.h..sSG..........s+GhHlal.............hhppth.sh....spspch.............................................................................................................................spthsppltp.pt..s...hhspt.ht.........................................................................................................................ph.h.h..lDht.ssphpshlps.....sh........ps...ss.t.lss.lt..............................................................................................	0	213	410	566
+1816	PF03604	DNA_RNApol_7kD		DNA directed RNA polymerase, 7 kDa subunit	Griffiths-Jones SR	anon	PRODOM	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.91	0.72	-4.48	22	397	2012-10-03 10:42:43	2003-04-07 12:59:11	8	6	344	96	272	368	26	32.10	48	44.18	CHANGED	YlCu...-Cuscsp.lpts-slRC+pCGaRILYKcR	.....YlCu...-Ct...pcsp...lc.t......t.-.s....I..RC+cCGaRIlYKcR...	0	81	151	225
+1817	PF00521	DNA_topoisoIV		DNA gyrase/topoisomerase IV, subunit A	Finn RD	anon	Pfam-B_55 (release 1.0)	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.44	0.70	-5.63	110	11276	2009-01-15 18:05:59	2003-04-07 12:59:11	15	57	5442	61	2091	8937	6799	383.20	48	53.48	CHANGED	RAlPcltDGLKPVQRRILauM.hc.h.hp.sppapKsAplVGpV..hupYHPHGDsSla-ulVpMAQ.sash..phsLl-spGNFGSh.sGDss.AAhRYhEs+Loclupp.lht-l-cpslcahssaDspptEPphLPshlPsLLlNGusGIAsGhATsIPPHNhtEll-uhhthl.c.s.ph...pl....hp.h..h.sPDFPouuhlh......st..pthhptYpsG...p..Gplp..lRuchph...........t...tpllITElPapsspssllc.pIscll....psp.....plp.lt..-lcDp.occ..sl+lllc..lcp...shp...sphlhst..LachTpLpsohsss.hslhcs.p...P+hh.slp-lLcpalcaRhcllp+RppapLpchpc+hc........llpthhhhh..........spl-tllplIcss.s.....tpps+p.pLhpc..lsc.....................................................................psctlL.shpLtpLTph-hp+lppEhpclppclpplcphlss...h.phhhc-Lc	...........................................RALPDlRD..GLKPVpRRlLYuM.pc.h.G................s........s.......+.....sa+KSARlV....G-V.....hGKY.HPHG............DoulY-uhV...RMAQ.sFoh..........RY.LV..DG..pGNFG..........Sh.DGDsu.AAM.RYTEuRh.ocl.u.tp.l.L............p.D..lsc....p..........TVDahsNa..Ds..oppEPtVLPu+hPNLLlNGu.o.GI.AVG..M..ATsIPPHNLsEllsushhhlc....ssphs......................hppLhp......h.....l.GPDFPT.uuhIh..........uppsIpcuYcTG.+....Gplh...hRuchchE................................ttt.ppllloElPa..p.................V...s...p...s...p.l......lc...pI.schh....ppK...............................+l......t..hI.s.......clRDE..S.....c..........+.....puhR.lVIc...l+c.....css.............sp...hl.h..Np...Lap......Tp..Lpt..sa.sh.Nh.l..........s..........l.ps.p....................Pphh..sLtphlptalpaphcllhRRptacLpKsppRhH............Ilc..GLhhAh...........tplDplI.tlIRtu.........s.........tts.......+ttLhtp..........thsc.....................................................................................Q..ApAIL.phpL.t+Lst.h.-t.cl..tEhpc.L.tpltpLttlLss..thh.plhtp-........................................................................	1	693	1331	1755
+1818	PF01556	CTDII	DnaJ_C;	DnaJ C terminal domain	Bashton M, Bateman A	anon	Pfam-B_342 (release 4.0)	Domain	This family consists of the C terminal region form the DnaJ protein.  It is always found associated with Pfam:PF00226 and Pfam:PF00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and this, CTDII, are necessary for maintaining the J-domains in their specific relative positions [2].	30.50	30.50	30.50	30.50	30.40	30.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.66	0.72	-4.08	113	11443	2009-09-12 04:15:19	2003-04-07 12:59:11	13	45	5229	30	3594	8830	3406	77.70	31	24.15	CHANGED	DLhh.pl.slohhpAllGsp.lpl..slcG..plplp....lssssps.Gphl......plpscGh...tps.........tpGDLhlplp.lp..hP..pp.l...s..s.pp+ph	.......................................slhh.pl.slsh....s.p..AsL..G.........s......p....lp......l......s.....T.....l..............c.........G...............p........lplp...............lP..s......G.......o..ps..Gpph...................Rl+G+.Ghsthpss........................tpG....DLhlplp..Vt...hP..p..p..l...s..t.ppp...................	0	1220	2251	3021
+1819	PF00684	DnaJ_CXXCXGXG		DnaJ central domain	Yamout M, Bateman A	anon	Pfam-B_89 (release 2.1)	Domain	The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc.  Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found [1].	32.70	32.70	32.70	32.70	32.60	32.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-11.02	0.72	-3.92	63	7168	2012-10-05 09:33:39	2003-04-07 12:59:11	14	35	5271	3	2059	5364	2289	63.40	43	16.70	CHANGED	CspCpGsGs.....ssssht.pCssCsGpGhhhptpp..h.hhhhphptsCspCpGpGph..h..pc.CppCpGpG	...................CcsCpGoGAc...........sGop...sp.....TCspCpGsGplphp......p...............Ghhphpps......CspC.pGpGph....I........c-PCppC+GpG................	0	693	1292	1727
+1820	PF03265	DNase_II		Deoxyribonuclease II	Mifsud W	anon	Pfam-B_4508 (release 6.5)	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  --amino -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.03	0.70	-5.43	37	585	2009-01-15 18:05:59	2003-04-07 12:59:11	10	37	128	0	441	567	4	252.60	21	48.86	CHANGED	hoChsppu.................psVDWFhlYKLPp.............GhpahYhDs....ss.ssWphustslsss.p.sslspTlpphh....ssspsshshlhYNDpPP.....ptps...ssphuHsKGVlhhcpp...pGFWllHSlPc.FPshs....hu.YsaPssspphGQphlClohshpphpp.IuptlhhppPhlYsssl........Psths..sph..spLpplspspph...........psshpppstlpohpG....tphptFuKss.passDlYs....shluptLpsslhlppWtpsss...hLsosCs.ssa.h.shshp.lsl..sp.....aspppDHSKWsVs............ssssasClG-hNRptppt+RGGGslChp............stplapsFpphst..php.sC	..................................................................................................................................................h.phh....hhhKh.st.....................................t.thhhhps..................ts..ttht......t..............h..st....t...tshtt.oht.h.......................tpt.......phhhhhYNstsP...........................t...............tt....h.....upsK..............G........l....lhh....spt...........tu.h.Wl.lHohPt.FPs......................s..a.........h.P.....s......t.....................................................Gp.hlChoh.t...t.p.....hpt....ls........t........lhh.tts.la..ph.................................s..t............t.h.......h.p...lhpt....................s..........hto...ts.......h..auK.t...t............................-ha.......................thl....h...h.t.t.s.h.s.........W.........tttt........s.Cp.................h..h...t..hth...t.t..............................ht..ttDp.up..ahls.....................tshhChss.sh.......tp..psuhhhCh................lht.hp..h....................................................................................................................................................................	0	336	365	405
+1821	PF01712	dNK		Deoxynucleoside kinase	Bashton M, Bateman A	anon	Pfam-B_1744 (release 4.1)	Family	This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76  and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine  and deoxycytosine.) These enzymes catalyse the production of  deoxynucleotide 5'-monophosphate from a deoxynucleoside.  Using ATP and yielding ADP in the process.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.82	0.71	-4.29	14	2493	2012-10-05 12:31:08	2003-04-07 12:59:11	14	11	1392	149	635	1837	992	145.40	25	62.65	CHANGED	hQhhhLspRh+.hhs.........pppshlh-RSlassphlFspshhcpGphspp-aphYppha-thh.phsp........cllIYLcss.-sslcRIc+RuRs.E..........sIsh-......Yh-pLc......thatthhpphshsshhhlcsschDh.ts.pc..phhpplh	.........................................................hQhaFLspRacphpc..................ttts.hlh.-R..S..la.pD.th......lF.t.p.t...h.h.cp.....G..ph......s..c...p-.aphYpcl.a...ch.h.h.pph.h.................................PD..llIYLc..s.sh-s.h.h.cR.....Ipc....R..GR..sh.E....................p.l.s...c..........................Yhc.p.Lp...............ptYcp.a...h........p....p......a....s....t....s....s......h...l...h..l...ss...sp..h.Dhhps.psht.......h..................................................	1	202	359	503
+1823	PF00404	Dockerin_1	celCC;	Dockerin type I repeat	Finn RD	anon	Prosite	Domain	The dockerin repeat is the binding partner of the cohesin domain Pfam:PF00963. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome [1]. The dockerin repeats, each bearing homology to the EF-hand calcium-binding loop bind calcium [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.28	0.73	-6.42	0.73	-4.01	130	1647	2012-10-02 16:17:27	2003-04-07 12:59:11	13	223	55	24	504	1211	47	21.00	49	5.22	CHANGED	DlNsDGpVsuhDhhhl++alh	..DlNuDGplNShDhslLK+YlL......	0	294	503	504
+1824	PF04118	Dopey_N		Dopey, N-terminal	Wood V, Finn RD	anon	Pfam-B_17466 (release 7.3);	Family	DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organisation of multicellular structures  in the filamentous fungus Aspergillus nidulans. DopA homologues are found in mammals.  S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis [1].	25.70	25.70	25.70	25.70	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.97	0.70	-5.65	37	385	2009-09-17 06:44:01	2003-04-07 12:59:11	9	9	257	0	258	391	0	285.80	37	15.96	CHANGED	pDt+h++asssl-+sLppF-o.lpEWADhIuhLu+L.KuLQ......ttsshshlPp+hhVu+RLuQCLsPsLPSGVHpKALElYshIFphlup-s...Lsc-LslahsGLhPhhuaASloV+shhlplhEpYhl.sLsp.sLcsshpullhuLLPGLE-EsSEhappshpLl-plp..ptlsps..............hFapslalsllsssphRLuuLsalsp+hspht........................................tpptp.hlss-ssLll+ulssuLsDc.......slLVpRshLDLLlpphPLsS....sl........l....stpDpphLlhushtlhh++DM.SLNRRlasWlLGspspspsst........pu	...............................................Dt+aRpYsusl-+ALppF-t..spEWADhIShLu+L.KsLQ...........................ps.ph..t.hlPc...+hhluKRLAQCLpPuLPuGVH.KALEsYphIFphlG..sct.............Lu+DL.lY...s...GLhPlLuhAuh..sV+............PhlLsLhEpahl.sLsp.sL+PuLpuhlhulLPGLE..E.sSEha-..+o.pL.l.pplp..ts.lspp...................................hFapsLWhull...sssuhRlsulsalhp+ls+hh...........................................................................................................hp..ptthh.....lus-...tLhlculssulpDp.......slLVQRshLDlllhthPhps....sh................hppsDh.hllpuuhtsll..RRDM..SLNRRLasWLLG.c.pt.....st.t.....................................................	0	92	133	203
+1825	PF04556	DpnII	DpmII;	DpnII restriction endonuclease	Kerrison ND	anon	DOMO:DM04410;	Family	Members of this family are type II restriction enzymes (EC:3.1.21.4).  They recognise the double-stranded unmethylated sequence GATC and cleave before G-1 [1]. http://rebase.neb.com/rebase/enz/DpnII.html	20.90	20.90	21.30	20.90	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.67	0.70	-5.34	19	239	2012-10-11 20:44:43	2003-04-07 12:59:11	7	3	216	0	35	188	11	259.50	38	88.94	CHANGED	cpac.FlpohpsTstshsYaVsapKVpcNlpp..hc...lcLNhLNhLIGcc..slcp-hhpLhpchPpllpslPhLlAlR-pphchhh..............stptsh.........shhphsFpp......hs..pl..-phhcFhcpTGLh.clhppptl+sLsDYVhGVEVGLDoNuRKNRoGchMEtllcphlpchs....shp.ahpQhphstlcch...auh-ls.....shtp++FDFsl..cspcKlYlIEsNaYsuuGSKlppsAppYpplspclp.tpsshcFlWITDGpG.W.pouKspLpEuFcplshlaNLphlcpuhLcclh	..................................t..Fc.alpshp.sostshsaasDapKlhcNlpplc..lpLNhLN.L..lG..pc..slppchhpLhpphPchhpslPlLlAhRppph.hh..........stptsh..............phsF..pp......hs.....h..-phh.FhccoGLh.plhps+hlpsLlDYVhGlEsGLDoNuRKNRoGchMEsllpphl.ppts....shs.........ahcphph...p...c...lcch...ash-ls.............sps.K+FDFVl.....cspphlYhIEsNFYuu.uGSKLNEsAcuYpplupc.hp.shsshcFlWlTDG.p.G.W.hsA+ssLpEsFc.....hl.hlYNlspl.cpshlppl.h..........................	0	15	27	33
+1826	PF04244	DPRP	DUF426; 	Deoxyribodipyrimidine photo-lyase-related protein	Mifsud W	anon	COG3046	Family	This family appears to be related to Pfam:PF00875.	21.00	21.00	21.20	24.00	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.55	0.70	-4.82	107	598	2009-09-14 12:31:16	2003-04-07 12:59:11	8	3	588	3	197	601	2407	216.30	32	43.34	CHANGED	LhLlLGDQLststuslpt....stsps.hllhsEstpEss.....YVtHHhQKlshhFuAMR+FAppLcppGapVtYhpL-.-....ststt..slsstLtchhppp.thpplthpcPsEaRLtpplcp.htt..thslsl.phhsss+Flssts-hpsahp..s.+KphpMEhFYRcMR++hslLMtsss.pPhGGcWNFDs-NR+phst.sh...phPpshpFpsD...thspcllphlppchs..sph......Gslcs...Fha	....................lhLlLGDQLs...ptuhhpp.....spspshhlhsElppEss.....YVhHHhQKlshhFuAMRpFAptL.ppp...GapVpYlplDs...stsht....shsstltph...hpph.t.spplphpcPsEaRLhpplpp.h.t..................hsl............sl...phhssc+FLsshs-hspahp.......s..p.....KplhM.EhFYRcMR..++hslLM....s.....ss...pP...hGGpWNaDs-NRcthsps..........phP.pshpass.....D.....spplhphlcpphh..sphGplps...h.a.................................................................	1	60	128	166
+1827	PF05219	DREV		DREV methyltransferase	Moxon SJ, Bateman A	anon	Pfam-B_6662 (release 7.7)	Family	This family contains DREV protein homologues from several eukaryotes. The function of this protein is unknown [1]. However, these proteins appear to be related to other methyltransferases (Bateman A pers obs).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.74	0.70	-5.52	3	166	2012-10-10 17:06:42	2003-04-07 12:59:11	7	4	121	0	102	1665	951	221.30	40	80.85	CHANGED	WYssN+E.Ls-shQulFVsShPDusTQpFL-NSpclSuNlFhQLaHuLusSILShFMS+TDINGhLGRGSMFlFSE-QFpKLLsIst.p.sSs.cs++LLDLGAGDGEITc+MuPaFEE........VYATELSpTMRsRLpKKsYNVLotlE.WQpTshpaDLIoCLNLLDRCasPhKLLcDI+s.ALcP.NGRVIVALVLPapHYVEsNs.G+ap+PcslLElsG..poaEEcVs+hh.EVF+sAGFcVEAWTRLPYLCEGDMaNSaYaLsDAIFVLKP	...................................................................................................................Y..p.p..ls..phtshFlt.....DptTp.FLppohphSs.hhhpha.+shspslh..p.hFhopTslNGh...L....tR.GuMFlhS.pQ.apcLL..p.h....s.................................s................p.s.......p..........p.....L.L......DlGAG.DG....p..VT.t.h.h....u...s...h...F...p...c.........................l....a....s....T.......E.....h..S.........................s.........M.......h.........h..............p........L.........p.........c..........+..........t........a................p............V.......l........s.....h........p.....-........a.......p.........p........p.........s.......h........p..........a.....D........lI....o...C....L....N....l...L.D.....R..C..-......p...P...h..s..L..L...ccl+p.sLpP...pG.h.l.l..L...A....l....V...L...P....a.p.s..Y..V.E.s....s....s.........p....p..pP..p..c.h......L....p..h......pG........tsaE.....-..p..l..s..p....h...p.V.h.t..sGF..l.ta...o...+lPY..LCEGDhhpsaYhLsDslhVLp..........................................................................................................................	0	41	52	81
+1828	PF02635	DrsE		DsrE/DsrF-like family	Mian N, Bateman A	anon	COG1553	Family	DsrE is a small soluble protein involved in intracellular sulfur  reduction [1]. This family also includes DsrF.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.48	0.71	-4.06	254	4389	2012-10-01 20:53:36	2003-04-07 12:59:11	10	5	1987	31	1183	3383	682	116.50	19	88.08	CHANGED	phlhhlsp.......sst.sphshthst...ss..tths.............hclt.lhhhusulthhhp............................h.....tp..thptLtp.t.....lphhlCtsuhpppuls.pp.............l..........phthsuhs.plsph.pp.u...phlph	..........................................................................................hhhlhpts.sh.ust.tstpuhph.s.....uh...tt.s..............tclt..lFhhs-.GVh..thhp....................................................s.tthsh...................hp....thptLst.ts......lplhlCs.ss.h....p....t.R...Glsttp................sL....h.......sh.ph.sshs...t.L.sphh.hp.s-.pllph................................................	0	373	740	996
+1829	PF01916	DS		Deoxyhypusine synthase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Eukaryotic initiation factor 5A (eIF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) EC:1.1.1.249. The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation [1].	21.00	21.00	21.60	23.00	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.65	0.70	-5.29	7	956	2012-10-03 09:55:27	2003-04-07 12:59:11	12	6	712	6	524	948	1511	277.10	35	85.61	CHANGED	hptLlchhtphGFQAo.plGcAscIhcpMhcp+..................p..pchslFhGYTSNlISSGlRchltaLVpcphlsslVTTAGGlEEDhIKsLus.thlG-atlcsppLRccGlNRIGNlhVPN-sYptFE-ahhsIh-phlp.pp....p.s..............hTsSchIaclG....Kcls...cEcSllYWAaKNpIPlFCPuLTDGSlGDMLaFaphcs.stpLplDlspDlp+lNshuhpu+csGhIILGGGlsKHaIhNAsLhRsGsDYAVYIsTup.aDGS.SGA.P-EAVSWGKI+scAchVcVauDAThlFPllVAtshs	.......................................h...lhpth...p.h.G.FpA...s.plucAhch.h.pp.Mhp.c.........................................t.spl.FLuhoushlouGl.R.c.h.lt.LlpcphV-slVoTuu.sl.E.E.Dhh.....cslu........p......a......h......G.......s.......a.......s.......h.......s.............s.t.p.LRppGl.NR...IsslhlP.p.-.s.a.p.t.h.E....c.al.h.s.lh-p..hhtcpp...................................................................aospchltc.lG.........ccIs.........sc...s....S.lhhhAhc.........p.......s.lPlasPulsDuSlGs...h.l..a....h...a....s.....h.....c....s...........s....t................l...........h.....l..D.h........l....p............D.h......pplss........h..............s...h...p........u.....p................c........s.......G....hlh....lGGGlsKca.........h........h.......s........s........s........l......h...........+.......s.........G...........t.......-........Y.....u...l........IssupphDGS..SGApPcEAlSWGKl...c...h...s...u...p....s...p............VauDATlshPLlsu.hh.......................	0	196	337	452
+1830	PF01323	DSBA		DSBA-like thioredoxin domain	Bateman A, Mifsud W	anon	Bateman A & Pfam-B_2082 (release 6.4) & Pfam-B_5982 (Release 7.5)	Domain	This family contains a diverse set of proteins with a thioredoxin-like structure Pfam:PF00085. This family also includes 2-hydroxychromene-2-carboxylate (HCCA) isomerase enzymes catalyse one step in prokaryotic polyaromatic hydrocarbon (PAH) catabolic pathways [2,3,4].  This family also contains members with functions other than HCCA isomerisation, such as Kappa family GSTs (e.g. Swiss:P24473), whose similarity to HCCA isomerases was not previously recognised.  The sequence Swiss:O07298 has been annotated as a dioxygenase but is almost certainly an HCCA isomerase enzyme. Similarly, the sequence Swiss:Q9ZI67 has been annotated as a dehydrogenase, but is most probably also an HCCA isomerase enzyme. In addition, the Rhizobium leguminosarum Swiss:Q52782 protein has been annotated as a putative glycerol-3-phosphate transfer protein, but is also most likely to be an HCCA isomerase enzyme (see [5]).	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.94	0.71	-4.75	30	5572	2012-10-03 14:45:55	2003-04-07 12:59:11	15	31	2655	78	1612	6482	3933	172.90	17	79.27	CHANGED	plchaFDahCPaCahuppplpphtpth................s.lclph+shslhss.....s.s..............p......th.......th.h.............sopputplhhhsttps....tphspthapshaspstshscps...ltplspcsGl.-ssp...hpphhsu...ssspstlccspptAtphultGlPshhl...ss......c.....hhhGssph-hltptlt	.................................................................................................l..ah-hhCPa.C.a.h.h.p.t....h....l.p.t..h.hpth........................................s..h..p..l..p..h..p...s.h....t...lhst...................................................................................................................................................................................................h..sshp...u.h...p.h..h...h.h.s.t...tps........................p..h..h.ts.l...a....c....u....h.....a.....p.....p........s......p......s....l....s.....s.......s......p.s...............l....t....p....l....h....t.....p....s.......G.........l...s.....t...t..p.................h.p...t...s.h...s...s.............s...h..p...s.t....l.....p.p...p....p....p.......t.......A..........t.......p...........h.........s....l..........p..........G.l..Ps.hll.........ss..........c...........hh.......G.t....t.h.....h........................................................................................................................	0	421	907	1308
+1831	PF02600	DsbB		Disulfide bond formation protein DsbB	Bashton M, Bateman A	anon	COG1495	Family	This family consists of disulfide bond formation protein DsbB from bacteria.\	  The DsbB protein oxidises the periplasmic protein DsbA which in turn oxidises cysteines in other periplasmic proteins in order to make disulfide bonds [1].  DsbB acts as a redox potential transducer across the cytoplasmic membrane and is an integral membrane protein [2]. DsbB posses six cysteines four of which are necessary for it proper function in vivo [1].	22.10	22.10	22.90	22.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.26	0.71	-4.43	184	2959	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	2169	13	514	1795	1819	155.50	23	77.26	CHANGED	M...............pt+thhhlhhlsuhshhhs.....AL.ahpal....hshtPCsLClhQRhshhslsllslluhht.........hchh.hhhhhlh.uhhGhhluhhHshlptt....t....sCs.........h.t.hshtphh...lhts.sss.Csphsap.h..lG................lohstWsllhFhhlsllhlhhhh	.................tht....t+hh.hhlhh.h.ss.hslhhs.....A.h.aaQal....hthtPCsLClhpRhshhshshsu.lluhlt...............hshchh...thh.hhl.h.uhhG....l....t....luh...p....H......sh......lphh..............Ps.s..h.s.....sCs.....hh.t..h...phh...shtphh...h..hhs...sss...C.sth...ht..h..hs.....................................lphsthth.hhFhhhhllhhh.h.h..................................................................	1	116	272	395
+1832	PF02683	DsbD		Cytochrome C biogenesis protein transmembrane region	Bashton M, Bateman A, Eberhardt R	anon	COG0785	Family	This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange  proteins.  These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.65	0.70	-4.73	10	5377	2012-10-02 18:22:22	2003-04-07 12:59:11	10	29	3528	0	1358	4319	2426	206.50	25	49.26	CHANGED	uFLAGlLShLSPClLPllPlalSaIoshshssh+pt.........hhpulhFlLGhollFluLGhusuhlsslht.tatshlphluulllIlhGLphluhh.................hLh+hphs..............................h...tpsps.hltuhLhGhsFAluWoPChuPlLuullshuusps..hhushhhslYsLGLulPhllsulFhs.hh....hh+tlp+ap+hlchsoGlLlllhGllhlh	...........................................................hluGll...h.h.o..P.C...l.LP.l.l...Ph...h...h.u.h.l...h....u........t.........p.......t....t...t.........h......p..tt.............................shh.t.s...h...h.a.l...h...G...h...u...l...s.......a.......s.h...L..........G.......h.........s...s.........u.......h......h.......G........t.......h......h.......t.............h.......t.....t..........h.......h.....h......h.....l....h...u..h........l.....h...l....l...h.......u.......L.....t...h...h.....u.h.hp......................................h..h.l...t.p....pph...............................................................p.p..p..t.s.s..t.h.h......u...s.a.lhGhhh.ul....s....h....oPC....s....u....P...s...L..u.....ul....L....s.h........s....u......s....s............u....s.......h..h..tG.s..h.h....h.h....s....a...u...L..G.....hu..l..P.h..l....l....l..u....l....h.s...s....h...hh..................h.h.....t..h...t.........t.........a........h........t..h....l.....c......t.......h...hG.h.l.lls.hulhh..h..........................................................	0	404	850	1135
+1833	PF01984	dsDNA_bind	DUF122; 	Double-stranded DNA-binding domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This domain is believed to bind double-stranded DNA [1] of 20 bases length.	26.00	26.00	26.60	29.70	25.60	25.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.38	0.72	-4.05	62	498	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	448	6	336	484	53	104.50	33	78.93	CHANGED	IR+p+h..tELQpp.............t.tttpppppppppt..........ctp+pulLpplLss-AR-RLspl+LV+P-hApsVEs.LIpLAQoGplpp+lo-cpLhplLpplspppcpp.....cIphsR	...................lRtt+htpLptp.........................ttttpptppp.ppppt...............................ppt+pu...lL...pQlLss-ARpRLuplpLVKP-+ActVEshLIphAppGpl.p..tKlo-cpLhplLpplspppcpp.....tplphpR...................	0	107	189	274
+1834	PF04077	DsrH		DsrH like protein	Kerrison ND, Finn RD	anon	COG2168	Family	DsrH  is involved in oxidation of intracellular sulphur in the phototrophic sulphur bacterium Chromatium vinosum D [1].	24.40	24.40	24.80	24.60	23.80	24.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.01	0.72	-4.32	66	948	2012-10-01 20:53:36	2003-04-07 12:59:11	7	1	944	13	166	473	50	86.00	41	91.11	CHANGED	+SPapstslpssL+hl....sssDslLLlpDuVh.Ashsssphhptlpt...pshplasLpsDlpARGl..tplsssl.........ph.lDYss..FVcLshc.Hpps.	........................SPa.s.-hsulLRLL....s-GDs..LLLlQDGVh.AAl......cu.sc......aLcsLps.............uslplYALpEDl..hARG...L....s...u.pl..S..s..s..l.........hh..lD..Yo-..FVcLTl+Hspp................	0	38	74	123
+1835	PF05160	DSS1_SEM1		DSS1/SEM1 family	Wood V, Mistry J	anon	Pfam-B_22209 (release 7.7)	Family	This family contains the breast cancer tumour suppressor BRCA2-interacting protein DSS1 and its homologue SEM1, both of which are short acidic proteins.  DSS1 has been shown to be a conserved component of the Rae1 mediated mRNA export pathway in Schizosaccharomyces pombe [1].	20.80	20.80	22.60	23.20	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.48	0.72	-4.19	28	295	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	233	7	210	264	3	62.30	45	64.59	CHANGED	ptspp...chssLE..EDDEFE-FPh--..Wssccsppsss........plWEEsWDDDDs.sDDFSpQL+pELcps	....................................t..tpt.chshLE..EDDEFE-FPs--..Wssp-...p-pss..................plWE-s.....W.....DDD.-l.pDDFSpQL+tELcc...................	1	67	115	171
+1836	PF00908	dTDP_sugar_isom		dTDP-4-dehydrorhamnose 3,5-epimerase	Bateman A	anon	Pfam-B_540 (release 3.0)	Domain	This family catalyse the isomerisation of dTDP-4-dehydro-6-deoxy -D-glucose with dTDP-4-dehydro-6-deoxy-L-mannose. The EC number of this enzyme is 5.1.3.13.	20.30	20.30	20.40	20.80	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.20	0.71	-4.95	19	3552	2012-10-10 13:59:34	2003-04-07 12:59:11	12	9	2817	55	902	2953	1971	172.40	40	87.60	CHANGED	hhchslssshllEPclFsD-RGaFhEoFspptFpctsstt.shVQ-NcShSup.GVLRGLHaQh.s.sQuKLVRslcGpVaDVAVDlRpsSPTaGcWsuVpLSs-N+ppLalPtGFAHGFhsLu-c.schhYKsoshYssppEpulpWsDPslGIcWPhtss.........lStKDtsus.hs-h	...........................................h..pstlsslhll-P.p.lFuDpRGaFhEsap..pc..p.....F.p......c......t....s.........h..............p.........t....s..........F.....V....Q.-.N.pS.hSpc..GVLRGLHaQht.............sQ...uKL.Vpll.p.G..p..VhD..V.sV..DlRcuSPTFGpWhu.shL....osc....N..........p....+plalPcGFA.HG.FhsL.o.-....s..sp......h.h..Y...Ks..s...s...a..Y.s...P.p...t...-...t...u...lt..asDPslu.IcW.P.h.t....s....t....................hlS-KDtttshLtcs.....................................	0	286	589	765
+1837	PF03942	DTW		DTW domain	Bateman A	anon	COG3148	Domain	This presumed domain is found in bacterial and eukaryotic proteins.  Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.	19.70	19.70	19.80	20.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.34	0.71	-5.11	13	1690	2009-01-15 18:05:59	2003-04-07 12:59:11	10	14	1061	0	506	1210	69	187.30	32	78.80	CHANGED	RthtCtcCtlshptCLCshl..PslpspsplhllpHssEst+shsTuhll...shsltcs.hhth.ch.t.s.p...........................h..hhttPshpshllFPucputshpcl..................................................hshssschhphIllDuTWscA+cha+psshL............csLP.pVsLtsptsSpYR.lR+usscspLsThEsuthhLshhpsp............cu.tpsLlphhcsht.paphspt	..........................................................................................h.tC...p.Ch.hs...p....h....ClCstl.........sshp....s....p...s..........phhllhassEs.h.+.s..o.N.TGRLl................ut.hl..s..c..s...t.s..a.....a..sRs..psstp...................................................................................................................................L.ht..hl....p..s.s..s.....h...p.shllF.P....u.p.h....u...tp..h..p..p....l.........................................................................................s....s..ss.+......sh....hI.h.L..DGTWpcA+KMa+.+.S.PaL...............................................................psLP...hls..l.s........s......p..h....S......tY..+....lRcsp..s...........psphsTsEsuht....lLphhscp.........................................ps.spsLh.phFpthhppa.h..pt...............................................................	0	139	241	393
+1838	PF01950	FBPase_3	DUF100; 	Fructose-1,6-bisphosphatase	Enright A, Ouzounis C, Bateman A, Mistry J	anon	Enright A	Family	This is a family of bacterial and archaeal fructose-1,6-bisphosphatases (FBPases).  FBPase catalyses the hydrolysis of D-fructose-1,6-bisphosphate (FBP) to D-fructose-6-phosphate (F6P) and orthophosphate and is an essential regulatory enzyme in the glyconeogenic pathway.	25.00	25.00	41.40	32.60	22.20	18.10	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.12	0.70	-5.46	33	184	2009-09-12 01:16:20	2003-04-07 12:59:11	11	2	177	8	111	177	25	352.60	55	96.70	CHANGED	hKlTlSlIKADVGulsGHopsHscLl-tscchLpcA.cpslLIDaaVopsGDDlpLlMTHp+GsDsc-lH.cLAWcsFhpuT.cVAK-LKLYGAGQDLLsDuFSGNV+GMGPGVAEMEFp.E.....RsSEPlllFtuDKTEPGAFNLPLY+MFADPFNTAGLVIDPsMHpGFpFEVhDVh.....-sKplhLssPEEhYDlLALIGssuRYVIK+Vap+.tsGc....l.....AAVsST-RLshIAG+YVGKDDPVsIVRsQSGFPAlGElLEPFA.hPHLVuGWMRGSHsGPLMPVshccAps..........TRFDGPPRVhALGFQls.cG+LlGP.sDhFcDPAFDhsRcpAtclA-ahRRpGPFpPHRLP.-EMEYT.TLPpVlcKLcsRFpsh	........KlTlSVIKADlGuhsGHshsHPcllctApchLp-A.ppslllDaaVopsGDDlpLIMTHp+GhDsp-lH.tLAWcAFppuT.cVAKcLtLYGAGQDLLpDuFSGNl+GhGPGVAEMEFpE......RsSEPlllFhADKTEPGAFNLPLY+hFADPFNTAGLVIDPsMHpGFpFEVhDlh.....EpKtlhLssPEEhYDlLALIGssuRYlI++Vap+.t.....sscl......AAVsST-RLshIAG+YVGKDDPVsIVRuQuGhPAlGElLEsFu.hPHLVuGWMRGSHpGPLMPVshcsAp..s..........TRFDGPPRVhALGFQlp.cG+LlG.....P.sDlFcDPAFDtsRppAhchA-hhR+pGPFpPHRLP.-EMEYT.TLPpVlcKLcsRFt.h............................	0	41	74	94
+1841	PF01954	DUF104		Protein of unknown function DUF104	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes short archaebacterial proteins of unknown function.\	      Archaeoglobus fulgidus has twelve copies of this protein, with several being clustered together in the genome.	21.60	21.60	21.80	21.70	21.10	21.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.93	0.72	-3.94	41	145	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	53	2	106	172	12	61.20	27	89.62	CHANGED	MsclI-AlYEsGVhKPLcKlcLcEGc+lplhlppt.........-lhc+htshlttpp.......t..pchlcE	....M.phIcAlYEsGVhKPL..cpl.c..LtEGpc...VplhIppt...........c.hcchhthht.t........................................................................................	0	46	70	92
+1842	PF01955	CbiZ	DUF105; 	Adenosylcobinamide amidohydrolase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This prokaryotic protein family includes CbiZ which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route [1].	21.00	21.00	21.00	21.20	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.35	0.71	-4.51	69	333	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	295	0	160	338	10	191.00	28	66.29	CHANGED	llchtpshpslSoushsGGhtp.sctlhNppVsp....sass...........sspphh.pchhpph..uh...psssuhhTAssh.cphshs....cshpVpshsTAGl.sNssphu..................................GTINlhlhsstsLscuAhspulhTATEAKstALh-hsl.........tuTGTuTDulsVss........tt..stthpauGstTclGphlucu....VhcAl	......................................h..phstshpslSouhh.sGGhtp.hptlhNtp.Vsp...shspt...............sstphh.pphhpph..uh..................psssuhhTAssh.cphshs..........c..s..h..tVtshsTAGl.sNuscsut..........................................................GTINlllhls.....ssLssuAhspAlhTsTEAKstAL.-hsh....t..................hATGTuTD.ulslss.........stt....stthpauGstTplGphlu+u....Vhpul........................	0	62	111	139
+1843	PF01956	DUF106	DUF106; Methyltrn_RNA_3;	Integral membrane protein DUF106	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function. Members are predicted to be integral membrane proteins.	25.60	25.60	26.00	25.70	25.50	24.80	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.72	63	665	2012-10-01 21:53:17	2003-04-07 12:59:11	11	4	418	0	446	621	77	171.30	25	75.18	CHANGED	slllss.lp......hhPhhllllllullpshhupllpthh..pp..sph......phpppphtpctcphpp.........................sss.thp.cphppccpthhpsppph.................................hhphhKs.hhhhlsphslhhWlshhFu....................Ghll.......t+lP.FPlhtphpthhptsl..tshssthso.lsWYFLshh.ulpplhphl....LGhss	............................................................................................sh..llhlhlullpthls.hl..p.........+p...sth.............phpc.pp.h....hcuctLcp...............................ssp.hht.tpp...h.ppccphhts.sppsh..............................................hhs.h.h.Kuthsh....hls.hhllh.ual..Nhh.Fs...........................GhVl.........sKlP...F.P..l..hh..thpshh.p.....pGl............shD...s....shs.......S.......lsWYF.Lssh.ulpphhphl.LG.s..........................................	0	142	240	363
+1844	PF01957	NfeD	DUF107; 	NfeD-like C-terminal, partner-binding	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	NfeD-like proteins are widely distributed throughout prokaryotes and are frequently associated with genes encoding stomatin-like proteins (slipins). There appear to be three major groups: an ancestral group with only an N-terminal serine protease domain and this C-terminal beta sheet-rich domain which is structurally very similar to the OB-fold domain, associated with its neighbouring slipin cluster; a second major group with an additional middle, membrane-spanning domain, associated in some species with eoslipin and in others with yqfA; a final 'artificial' group which unites truncated forms lacking the protease region and associated with their ancestral gene partner, either yqfA or eoslipin. This NefD, C-terminal, domain appears to be the major one for relating to the associated protein. NfeD homologues are clearly reliant on their conserved gene neighbour which is assumed to be necessary for function, either through direct physical interaction or by functioning in the same pathway, possibly involve with lipid-rafts [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.79	0.71	-4.05	29	3477	2012-10-02 01:11:51	2003-04-07 12:59:11	13	7	2863	3	986	2665	624	137.70	20	67.86	CHANGED	hhlllGhlLlshEhh..hsshuhluhuGlsuhllGslhlhs...................hshhhshtlhhhhhhshlthhlh+t....+pppss.psh.....csllGcpupl...ts...hhsspGhlplcGphWpsput-....lttGcpVcVluhcGhsLhVpcps	............................................................hWlhlu.hlL...l..hhEh..........hssh...h..h..h.....h.h.s..G..l...u..u...h..l..s....u.h.lh.h.hh.........................................hs.hh.h.h....h..t..s.l.h.....h.h...h..l...s....h.l........t.....h............h.....h.....h.+...p......h..h...t...t..p.t.p.p.pt..t.................................ppl...l...G...p..pu.hl.......ps....................hs..s..s....p......G......p....l......c......l.....s.......u.......p.....t......W...s.....s...p....utss...........lts.G..s..c.V....pVlt.l...-...Gh.pLhVp...h............................	0	335	648	832
+1845	PF01958	DUF108		Domain of unknown function DUF108	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has no known function.  It is found to compose the complete protein in archaebacteria and a single domain in a large C. elegans protein Swiss:Q19527.	21.00	21.00	33.40	32.40	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.94	0.72	-3.76	65	431	2009-09-10 18:08:58	2003-04-07 12:59:11	13	7	393	4	169	403	114	91.40	37	34.30	CHANGED	pslspss..slFcGsApEAsptFPpNsNVAAsluLAu..hG............h-pspVcllADPss.stNhH-IplcG......shGphphplcshP.ssNP+TShlsAhSllp	.......s..hsctp.llFcGoA+E.....AsphaPpNsNVAAsluLAu..lG............h-pTpVclhADPsh.spNsHclpscG......shGphplplps.hPhss.NP+TSslsuhSsl.................	0	50	101	138
+1846	PF01959	DHQS	DUF109; 	3-dehydroquinate synthase (EC 4.6.1.3)	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	3-Dehydroquinate synthase is an enzyme in the common pathway of aromatic amino acid biosynthesis that catalyses the conversion of  3-deoxy-D-arabino-heptulosonic acid 7-phosphate (DAHP) into 3-dehydroquinic acid [1]. This synthesis of aromatic amino acids is an essential metabolic function for most prokaryotic as well as lower eukaryotic cells, including plants. The pathway is absent in humans; therefore, DHQS represents a potential target for the development of novel and selective antimicrobial agents. Owing to the threat posed by the spread of pathogenic bacteria resistant to many currently used antimicrobial drugs, there is clearly a need to develop new anti-infective drugs acting at novel targets. A further potential use for DHQS inhibitors is as herbicides [2].	21.20	21.20	33.70	32.40	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.01	0.70	-5.76	26	211	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	183	0	126	218	104	339.40	38	94.02	CHANGED	KplWl..s.t..ssW-tpKchlTsuLEuGsDsVlVsp.tclc+V+cLGplplhu..................................s...h.........ht.h.......GpssusYlcIpsc-pEphAtchuc...s-alIltupDWplIPLENLIAtl.tpcscllAsVpss-EAcsAhpsLE+GsDGVLLcsc..Dss-l+chsphhcphspEp..lcLp.ApVTclcslGhGDRVCVDTCSlMpcGEGMLVGShSpGhFLVHuEThEsPYVAuRPFRVNAGAVHAYlhsPss+T+YLuELpuGDcVhlVDpcGpsRpAlVGRlKIE+RPLhLlEA..Es.cG.cclpslLQNAETI+LVss-GpslSVs-L+sGDcVLlhh-p...suRHFGhtl.-EoIIEK	.............................................................................................al...........p..+thlptulEsGh.ss.llhtt...tp.h.....tt.h.p.pl....up.h..plhs.............................................................................................h.......tt.spchushlp.lps.ppp......chAt.phup...sshsll.s.p...DWp.....lIPLENllAt..h..t......p..ps............plluhs...p...sscEAclshps..........LEpGsDGVllpsc......shs-l+clhp.......hh...........cp............s..p........pp...........lpLs.AsVTplc..l.GhGDRVCVDTsSlhc.GEGhL..VGShSpGhFLVHuEohcss.YluoRPFRVNAGuVHuYlhsPss+TpYLSELcuGccVllVc.pcGpsRpuhVGRVKIE.pRPLlLl-....Acs......sG.....cphsslLQNAETIRLl.......s.s......s......G.....p...slu....VspLKsGDcVLshhpp...suRHhGhtl.pEhIlE+...............	0	43	92	117
+1847	PF01345	DUF11		Domain of unknown function DUF11	Bateman A	anon	Pfam-B_1553 (release 3.0)	Domain	A domain of unknown function found in multiple copies in several archaebacterial proteins.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.51	0.72	-3.93	35	6559	2012-10-03 16:25:20	2003-04-07 12:59:11	13	229	570	0	1139	6240	824	72.90	27	22.92	CHANGED	sssssssssssp..ssssshssssssshtlspssssssspsG-slsaTloVoNsGsss.uss..VsVpDhl....PsGhsassso	.............................................................ssss..................................s.........h....s....p.....u.......s...l..s....s...s...K......o.....s.......s.......p...s....h..........s...s.........l......G.......-..s.l..........TY.Tlsl..s..N..s....G.....s.....s......s.....A.....s...s........VhhsDsl........Ps.G..soFlsso........................	0	455	877	1040
+1849	PF01969	DUF111		Protein of unknown function DUF111	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This prokaryotic family has no known function.	19.90	19.90	26.20	23.10	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.28	0.70	-5.66	103	749	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	627	1	290	733	394	342.40	33	95.11	CHANGED	LahDs.huGluGDMhLuALlDLGl..shch.lpptLppLsl.....st...apLphpcsp+pGlpup+lcVph.............................................................................ptpp..................c................Rp.......hs-I...tplIp.su.....sLsspl+ptuhplFppLAcAEA+VHGh.sl-cVHFHEVGAlDuIlDIVGsshul-hLs....l-c.......lhsoPlsh...GuGhVcsAHGhlPVPAPAslElL..cslP.lhs..ssh.p.....sELsTPTGAAllssluspasshPs.hplpplGYG..uGs+-hs..hPNlLRlhluc.............................tps.thpp-plhllETslDDhssEhlualhEpLhps.GAlDVhhsPlhMKKuRPGhhlsVls..pscptppltpllhpEToTlGlRhpth.pRhhLpRchtplpTshG....plpVKhuh.hsut....hhphpPEa-DspclApcp..slPlpcVhp	...............................................................................lahDs.hsGluGDMhluALlDh.......Gs.......s................p...h....l...p...tlppLsl.....tt..............hplphpch.+..p..GltutphpV.ht.................................................................................................................................................................p...ppt..........................c...............Rpht-I.hplIp.pu........s.Lsptl+phuhtlFphl.Ap.AEuplHGh.s.h-pVHFHEVGAh.D.uIlDIlGsslsl-.Ls....hcp.......lhsoslsh...GsGh.lpsuHGhhPVPsPAshclh.............psls..lht..t.sh...p.........sELsTPTGAAlltsls......s.p......a..s..........ss.hplpplGhG..s..Gp+-h.....t..hsNlLRshlhc........................................................................................tt...t.ttcplhhlEsslDDhssEhhuh.hh-tLhpt.GAhDVahpPlhMKKsRPuhhlslls.....p.pphpthtpllhpcToolGl.Rhh.h.pRhhhp.Rpht..plps.hG.....................................plplKhsh..h.....tst.................hhphpPEa--htplApptshshpplh.t..............................................	0	134	237	275
+1850	PF01970	TctA	DUF112;	Tripartite tricarboxylate transporter TctA family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [1]. TctA is part of the tripartite TctABC system which, as characterised in S. typhimurium [2], is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules [1].	20.40	20.40	21.50	21.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.26	0.70	-6.07	199	2024	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	1089	0	682	1865	3145	407.50	36	83.48	CHANGED	sLhhhhhG.shlGhllGslPGLusshulAlLlPlTas..h.....s........PhsulhhL.sulYhGuhaGGulsuILLslPGssuussTslDGasMAppGcuupALulusluShlGGhlu....slhLhhhuPhluplALp.FGssEaFsLhlhuLs.hlusluus.s.hh.............KulhushlGLhluhlGhDshsG.h.Ra.TFG..........pLh.sGlshlslhlGLFuluElltt....h..................t..ptph..tph....tt.h.h.s.....hp-htcthhshl.RuohlGshlGhLPGsGuslAualuYs........................ht++.ho..+psc..p..F..Gc.Gsh-GlsAsEuANNA...ssuuuhlPhLsLGIPGsussAlllGuhhlpG...lpPGPhlhpppsp..llaullsuhhluNlhhlllslhh.ht.h.as+.llplPtphLhPhIllhshlGsYuls....ssh.hDlhlhlshGllGahhc+hshs.........huPll........L	..............................LhhsllGshlGsllGsLPGLGsssul..A..lLLPlTau..h.............sPtu..ullhL.uulYhGuhaGGuhouILlNhPGssuulsTshDGasMA.pp.G.+.AGtALuhusluSFhGGhlu.......sl.hl.hhh...A...P..............h.LAph.......A.Lp..F..Gs...sEYFuLhlhuls.sluuh.su...p..s..hl..............Kulhu.s.h..lGLhlu.....sl..GhDsho....G.s.Ra..TF....s..s.........pLh.sGls.hlslhlG.LFul......uEllhhh...............tppp.p.t.ph.....h.t.ph..........sp...h...hhs...............hp-htp.h.h.h.shl..RuollGhh.lGlLP.G.uGAsl.......A.ualuYs...............................hpK+..hu.......+..p.sc....p..F...Gc..GslcG.lu.AP.EuANNA...u.s.s.G.uh.lPhL..TLGlPGsuss....A.....l....h.lG...Alh.laG......lpPGP...hlFs.....p.....ps.-...............l..saullsu..hhluNlhLllls.lsh....ls.las+......lLplPh.................th..LhP.....hIl...h.h...s..hlGsYu.ls..........ssh...hDlhlhlshGllGahhc+hsaP.........huPllL.................................................................................................................	0	185	421	574
+1852	PF01972	SDH_sah	DUF114;	Serine dehydrogenase proteinase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaebacterial proteins, formerly known as DUF114, has been found to be a serine dehydrogenase proteinase distantly related to ClpP proteinases that belong to the serine proteinase superfamily. The family has a catalytic triad of Ser, Asp, His residues, which shows an altered residue ordering compared with the ClpP proteinases but similar to that of the carboxypeptidase clan [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.71	0.70	-5.63	4	404	2012-10-02 13:07:06	2003-04-07 12:59:11	11	4	342	0	216	2161	936	193.70	28	59.54	CHANGED	h.hhDPhou.l.uLhWaLLFhaLlhuPphphptLlhARh+slRclppKRsSpVITMIHRQEuIGFLGIPIY+FITIEDSEclLRAIRhTPcDhPIDLIIHTPGGLsLAATQIApAL+cH.AcTpVIVPHYAMSGGTLIALAADEIIMDcNAVLGPVDPQlGpYPAsSILKslE+KsscclDDpTLIhADIucKAIpQhp-hVasLL.KDKhs-EKAKElAKhLTpG+WTHDYPLTVEcLKpLGLcVsTNVPcEVYELMELY.QPMtp+ss.VpalPsPhK...pEpsAK	...................................................................................hhh......................................................................................................................h.....c.tl.p......h.........s...h...s...I...s...L.l...l...c...TPGG....h....V.....AA....t....pI....u....p....t...l....p....p....p..s.....s.....c.....s....s............l....h...V....P...c...h.....Ah....SuGT.lIA.L.uAD...c..IlMs.sus..........lG.....P.....l.....D.....P.......p........l........t........t...........................................................................................................................................................................................................................................................................................................................................................................................tsh...................................................................................................................................	1	96	153	185
+1853	PF01973	MAF_flag10	DUF115;	Protein of unknown function DUF115	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaebacterial proteins has no known function.	33.30	33.30	33.30	33.30	33.10	33.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.09	0.71	-4.75	151	1412	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	624	0	345	1270	190	143.60	25	34.65	CHANGED	pphlpNlsphhp......hppLhs....pt....cs..slllusGPSLccp.lshl.+php....pchlIlusssuhphLhcpGIpPDhlls.lDt....hshc....h..hpph.p........slhllhsptss.chlpthpspph.hhhhsp..........hshh..t..t..........hhsGhoVuphuhplA.hthGtcpIlLlG.Dhuasps	.............................................................................hht.................hhlhusGPSLt.pt..l.hl..pt............tp..hhlhss.ss.uh.hL.hptsI.tPD.....hlh...l-t.....hs..c.............h.hpp..tp........................slhhlh.ssh.sp......ps.l...p..hh...ptpph...hhhhtps....................................hthh...p..th.................htsGh.....oVu.phuhtLA.ht.lshc...sIlhlG.Dhuas........................................................	0	131	239	288
+1854	PF01976	DUF116		Protein of unknown function DUF116	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein has no known function. The protein contains seven conserved cysteines and may also be an integral membrane protein.	25.00	25.00	26.20	25.40	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.23	0.71	-4.74	48	272	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	245	0	133	254	20	161.60	30	58.26	CHANGED	hhshhchlh......................................phhuhcc..phlpphhIplpNphhtspht...................ch.scchllllPHCLppsc...Cst+lTs.cs.pC.pcCG.+Csluclhclu-chGhc.lhllsGuohs+............+llcct+Pc....ullulAC.p-LppGhpc.........hpt...lPs..hGVl.p+ss..C........hsTpV-hpplhchlp	.............................................................h...hhhhls.....phhshpc..phlpp.hlcl...pNphh.hppht...................c.h.scchllLlPHClp.sp......C.h+lTp...ch.sC.....+cCG..+Csluslhclucch.G.hc...lhlsTGGTlA+............+hlpct+Pc....ulluVACc+DLtpGhpc.........sps...lPshGVlsp+sstsC...............hsTpVshpcl.phl.t...................................................	0	54	101	121
+1855	PF01978	TrmB	DUF118; 	Sugar-specific transcriptional regulator TrmB	Enright A, Ouzounis C, Bateman A, Studholme DJ	anon	Enright A	Family	One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter [2] in Thermococcus litoralis.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.86	0.72	-4.27	51	1668	2012-10-04 14:01:12	2003-04-07 12:59:11	14	47	710	5	702	5171	791	67.60	24	27.24	CHANGED	Lp.plGlochEucsYhsLl...ppusssup-lucpsslP+s+lYclLpsLhc+GhVphtp.up......Pt.hYpslssc	......................................thGhsph.Esc..s..YhsL.....l.......pp.u....s......h......o.....u.......p.-.l....ucp.s....u.....l....s..+......u....p.l.Y....csLppL....h....ccGh.V.ttpp..sp.....................sh.hY.tshs..................................................	0	181	429	610
+1856	PF01982	CTP-dep_RFKase	DUF120; 	Domain of unknown function DUF120	Enright A, Ouzounis C, Bateman A, Coggill P	anon	Enright A	Family	This domain is a CTP-dependent riboflavin kinase (RFK), found in archaea, that catalyses the phosphorylation of riboflavin to form flavin mononucleotide in riboflavin biosynthesis EC:2.7.1.26. Its structure resembles a RIFT barrel, structurally similar to but topologically distinct from bacterial and eukaryotic examples. The N-terminal is a winged helix-turn-helix DNA-binding domain, and the C-terminal half is most similar in sequence to a group of cradle-loop barrels. Swiss:O28174 has this domain attached to Pfam:PF00325.	25.00	25.00	66.80	66.10	22.80	20.10	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.50	0.71	-4.49	44	155	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	152	8	103	158	96	120.50	38	62.91	CHANGED	VsSGLGEGpaYlol.hYpcpFcctLGFpPaPGTLNl+lssp.t.h.htttlcphpslhI.Gap.pssRsaGuV+sassplss.....lpuA......llhPpRTpHspcllElIAPhpLRcpLsLcDGDcVplpl	..VlSGlGEGpaYlSl.hYpcpFcchLGFcPaPGTLNlclppp...hphhttl.cshpslhI.uap.pssRsaGsV+sa.splss......lpuA......llhPpR..TpHs.psllElIAPhpLR-pLsLcDGDpVplpl..........	0	26	61	84
+1857	PF01983	CofC	DUF121;	Guanylyl transferase CofC like	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Coenzyme F420 is a hydride carrier cofactor that functions during methanogenesis.  This family of proteins represents CofC, a nucleotidyl transferase that is involved in coenzyme F420 biosynthesis.  CofC has been shown to catalyse the formation of lactyl-2-diphospho-5'-guanosine from 2-phospho-L-lactate and GTP [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.46	0.70	-5.38	3	277	2012-10-03 05:28:31	2003-04-07 12:59:11	11	3	269	2	130	665	682	192.50	28	86.28	CHANGED	M+lIIPVSshNpsKTRLSshLSsEERKsLL+sMLhDVIcALcs.lD.llllScDE-VL-aAhssLGlEllcEc..+DLNsAlcQA..Fpt.E-ccVIIIPSDIPLIuKcclcclL-puuphDVVIAPuRGGGTNhLlLR.Kcuhcl+YcssSFFKHLEEARKRGL+spIYDSFYlSVDINTsEDLGEIhlHGsGT+o+EYLRKLGFoVcPc+oSchRhcVpRp	.........................................................................................hh..lllPVKpl...stAKoRLu.ss.....h.s.......s..pp....Rps..ls...h....A....M....L....t......D.....s......l.......s....A...s...t.....s......l.....s.....l....s...V..l........o....s...D...t.......s.......s....s.s...h.u..t................t..........h.....G...u.....p..l.l....sD..............s........t..........p.....s...........L....N.......s...Al....stu..............h.h...t........t....s....s....s.......s....ll.l..l....uDLPhlpsp-Ls...p.h..l..s..s..u...........t....p.....h....c.....s..h..lu.s...s..p.G.s..GTs...sL...h.h.t....s..s.t....h.....p.........s.......p..a.s.s..s..S...h..t.H...t...........................................Dls...ch.................................................................................tttth................................................................................	2	39	96	119
+1858	PF01986	DUF123		Domain of unknown function DUF123	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial domain has no known function. It is attached to an endonuclease domain in Swiss:Q58030. The domain contains several conserved cysteines and histidines.  This suggests that the domain may be a zinc binding nucleic acid interaction domain (Bateman A unpubl.).	25.00	25.00	27.50	25.60	21.20	24.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.76	0.72	-3.89	69	232	2012-10-01 19:55:08	2003-04-07 12:59:11	11	4	224	0	149	235	33	93.40	35	50.11	CHANGED	phphptGhYsYlGSAht.su.....htpRltRHhp..tst.+..............................h+WHIDYLlt..psplstl.h.hhsppc....hEstluptLsphst....l.tGFGuSDsp..stSHLahhs	..............t.hphptGhYhYlGSAh..su.....ltpRlpRHhpps+...............................ph+WHIDYLhs...psphhts..h..s.stc....hEsplAptlsphht.....ltuFGuSDCp..CtSHLahh.p.........................	0	51	97	124
+1859	PF01987	AIM24	DUF124;	Mitochondrial biogenesis AIM24	Enright A, Ouzounis C, Bateman A, Eberhardt R	anon	Enright A	Family	In eukaryotes, this domain is involved in mitochondrial biogenesis [1]. Its function in prokaryotes in unknown.	20.80	20.80	21.00	20.80	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.54	0.70	-4.88	153	1844	2009-01-15 18:05:59	2003-04-07 12:59:11	12	16	1144	7	748	1709	223	204.60	25	77.57	CHANGED	aplh.tsshphlclpL.t.sucslhscsGuMlhhs....uslphps..th............th....lhtulp........chlsGEuhFhs.hp...tspG.pGclhlAss.hsGp.lhhlcL.ss.........p.tlhlppsuaLAs.sssl....phchpht......thttu..........hhu...........Gp..Ghhhh+lp...G.pGhlhlpu...hGslhphplt..scslhVDsuplVAassslpa.......plpps.s................................................thhuth.hu...GEGl..hh.php...Gs.G.pVhlQ.ohs	......................................................................................................t.shphlplpLt..ssp..s.lh.....sc.....s.GuMhhhp...................sslphps.h.t.............................utlhtthp...........phlo.GEuhhhs.hh........tspG..pGplhhAsshs.........sp..l..h.s.lcL..ss....................tpl.hl.p..p..ssaLAh.ss.s.l.....phshpht.....th.tu......................hhu......................Gp...Ghhh.h.p...lp...........G.....pG...h...lhlpu....tGslhph.p.l...t...sc.plhlDssplVAa...ss..s...l..ph..........slphs.s.....................................................................................shhsth...hu.........GEG.l....hh..ph..p....G.s..G...pVh.lQoh...................................................................................................	1	239	508	668
+1860	PF01988	VIT1	DUF125;	VIT family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the vacuolar Fe2+/Mn2+ uptake transporter Swiss:P47818, Ccc1 [1] and the vacuolar iron transporter VIT1 Swiss:Q9ZUA5.	28.10	28.10	28.10	28.10	27.90	28.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.37	0.70	-4.85	143	2783	2009-09-13 10:13:07	2003-04-07 12:59:11	14	11	1699	0	1169	2391	416	165.10	25	72.77	CHANGED	hlRssV.hGusDGllosh.ullsGluuss...s.......s.st..slllsGlusl.lAuuh.SMuhGpYlSspupp-htptphpc.p..th.t..ptpht.phhthhtpp.Glstphspphspth.t...................t...............................................................ht.hh..thsh................pPhtuAlsosluahlGullPllsahlh....................shhholhhshlsLhllGhhtuths.s........tshhpuslchlhhGhlussloahlGtl	......................................................................................................................hpshlhGh.DGllssh.ullhGluuus.........s.....lhlsGhushluuuh.SMuhG-alSspsp............t-..tt.ht........h.........t...................h...hh.t...s...t.h......hs..h................................t..........................................................................h....tht...............s...............pPhpuAhsohhuahlG.....ulhPhlshhhh................................hthhhshh.hs.h..lsLhhhGhhtuhhs.t................................tshhpuhhc.lhhGhhshshshhlG..........................................................................................	0	357	761	1000
+1861	PF01989	DUF126		Protein of unknown function DUF126	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function.	19.30	19.30	26.90	32.90	18.50	17.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.51	0.72	-4.31	60	282	2012-10-01 19:37:30	2003-04-07 12:59:11	11	2	253	1	142	284	192	84.60	37	34.22	CHANGED	slSFhGGVDPpTGhllDhtHslhGpSlsG+lLlhPsu+GSosGShVlh.pLtpsGpAPtAllhp.csEsIlshGAllAs......lPl...lst	...................lSFhGGVDPpoGhll-p.pHsLpGpslsG+lLlhPsu+GSos.GSh.Vlh.pLhpsGpuPsAl.lhp.c.s.-sIlshGAllAp..........lPll.t............	1	42	83	110
+1862	PF01994	Trm56	DUF127;	tRNA ribose 2'-O-methyltransferase, aTrm56	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family is an aTrm56 that catalyses the 2'-O-methylation of the cytidine residue in archaeal tRNA, using S-adenosyl-L-methionine. Biochemical assays showed that aTrm56 forms a dimer and prefers the L-shaped tRNA to the lambda form as its substrate [1] [2].  aTrm56 consists of the SPOUT domain, which contains the characteristic deep trefoil knot for AdoMet binding, and a unique C-terminal beta-hairpin [3].	25.00	25.00	79.40	95.80	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.59	0.71	-4.37	31	143	2012-10-01 22:53:19	2003-04-07 12:59:11	11	2	140	4	88	146	75	121.00	48	66.03	CHANGED	WGGs..FpVchsssa+phl+ca+ptuGhVVHLTMYGhsls-lhscI+...................pscc...lLllVGAEKVPt-lY-hADYNVuVGNQPHSEVAALAlFLDRLhcGcpLpp-FtsA+lpllPpc+GKcVlct	......WGGs..Fp.lchsssa+phl+cW+t.ts.....GhVVHLTMYGhsls-.lhscI+.........................p..p..p.cs....lLlVVGAEKVPt-lY-hADaNVuVGNQPHSEVAALAlFLDRLhcG+pLpp-FpsAcl+llPpppGK+Vlph..	0	21	53	73
+1863	PF01995	DUF128		Domain of unknown function DUF128	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function. The domain is found duplicated in Swiss:O27611. Many of these are attached to an N-terminal winged helix domain suggesting these are transcriptional regulators and that this domain has a ligand binding function.	25.00	25.00	63.90	27.70	22.10	23.00	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.26	0.70	-5.43	36	122	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	69	2	87	121	4	228.30	32	79.15	CHANGED	lsFlhS+lpchhapssaD.tptpGcVllNhohlp..............ccch-pslcllccshcsG..huloshlplhccs.t.......tsplsItTlCSlThDGlLL+sGIPspPtYGGllclcstpPhRFp-lIsYcuTSlDPlclFhspshTsVhphhcsGpGtlLANlRplPhsAc-chcpllccl.t.uhsGll..plGcsspslhGlsVppsplGlshlGGlNPlsshpEtGlslchpshpslh-apphpch	............lshlhS+l.phhapssaD.pptpGpVllNhohlt..............cpphccslclhccshcsG..huloshlplhcc............psplsltTlCSlTlDGlLL+sGIPspPpaGGllclcs..tpPh+Ft-lIsYcuTSlDPlclFhsp.....shTsVhthhpsGpGplLANhRplPhsuc-chpcllccL.t.uhsGll..plGc..sspsl.hGlsVs.psphG.lshh.GGl..NPlushpEpGlslchpshpslhchpphpp.h.........	0	22	58	75
+1864	PF01996	F420_ligase	DUF129; 	F420-0:Gamma-glutamyl ligase	Enright A, Ouzounis C, Bateman A, MorningStar A, Mistry J	anon	Enright A	Family	F420-0:Gamma-glutamyl ligase (EC:6.3.2.-) is an enzyme involved in F420 biosynthesis pathway.  It catalyses the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0). This reaction produces polyglutamated F420 derivatives.  GTP + F420-0 + n L-glutamate -> GDP + phosphate + F420-n	25.00	25.00	25.70	25.30	21.70	22.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.48	0.70	-5.29	91	759	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	642	4	296	699	526	231.60	28	69.99	CHANGED	slcsh..lcs..GDD..Lspllhpuht..........lp-GDllVlupplVS+AEGRhlshsslpPu....................................Ah.lu..ht........tssph.........hplllcE...............................usclltt........tsshhlsps+tGhl.....hssAGlDp.........................SNs........sss....llLLPcDPcsSAcpl+ptlpphhGh....pVuVlI......sDohGRsaRhG....tsulAlGsuG......ltslt..-htGp.pDh.hGctLp.....................hT..uluDplAuuAsLlhGcusptsPlsllRGh	.........................sltsh..lp.GDD..lsplltpss.........................lp-sDllslopplVu+spGphsshspht.s.........................................h..hs............hs.th.......................hpllhpE............................................................................................................sscllht..........tstshlspsppGhh........hssAGlDt....................................................................................................................................SNs.........ssst....lhLhP.p-..P..cssApplpptlpphhu.h....pluVl.l......sDoh..G+.a+hG....tsshulGhsG................ltslt..shtu...hD..hsp.lt...............................sT..slsD.luuhusLshGphst.hPlsllpG.............................................	0	110	228	272
+1866	PF02343	TRA-1_regulated	DUF130; R03H10.4; 	TRA-1 regulated protein R03H10.4	Bashton M, Bateman A	anon	Pfam-B_814 (release 5.2)	Family	This family of proteins represents the protein product of the gene R03H10.4 which is located near a sequence that matches the TRA-1 binding consensus. TRA-1 is a transcription factor which controls sexual differentiation in C.elegans. R03H10.4 shows male-enriched reporter gene expression and acts as a direct target of TRA-1 regulation [1].	19.40	19.40	19.40	19.70	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.97	0.71	-4.64	23	100	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	4	0	99	115	0	124.20	26	71.88	CHANGED	clC.s.psspCPDLtshh............sshpl..s-tDGCss.loCs.suphPhhhupassSEIsss.ss..ssshshFtlhsPhohsphsu..........slhcaaGllCE....sspWphTKYPpGIthh..ss...hhGsDGShsGKKotlttlsC	.....................................t........tspCsclhs..hh......................st..h.....p-tsGCsh.loCs...ss.t.h.shlhh..tasp.SEIs.h..P..ss...s.ss....t.hh...thh...s.s.s.tt.hs..sh...............................slhsaFGllC.E....sspWhsTKYPhGlt..............Yhs......ss......hhu....ss.uphsGK..Koplt.hth.......................	0	42	42	99
+1867	PF01998	DUF131		Protein of unknown function DUF131	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein family has no known function. The proteins are predicted to contain two transmembrane helices.	20.80	20.80	21.60	25.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.16	0.72	-4.61	35	123	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	85	0	87	115	3	65.00	29	72.33	CHANGED	hlGshltsht......................................pscscschGGllhIGPIPIlFGos.....pphshhuhlLAlllhllhllhhh	....................................h.....h.........................................pppcspscsGGVlhIGPIPIlFGou......pph..shhslllAlllhllhllhh.......	0	26	46	65
+1868	PF02001	DUF134		Protein of unknown function  DUF134	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaeal proteins has no known function.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.56	0.72	-4.14	4	568	2012-10-04 14:01:12	2003-04-07 12:59:11	11	5	485	0	227	751	43	94.30	39	66.00	CHANGED	M.t....+sRsR+hRhIhhp..PpVRtFhPch..stTG..K..Vhlol-EhEAlRLVDYc-hoQ--AuchMGIS+sTlWRhLTuARKKlApALlEGR..hIlhcGGEhhpc	...........................................................................RPpphR.p..lpth...Pt.h..p..hFt.Ptu.......shpp.............l.h.....L....sh.....-.Eh........E....A.l.R.LhD....h.cG.LsQp-uAppMtVSRpThtpllp..sARp.KlAcuL..lpG+..hlhlpGG.h...ht.......................	0	87	154	191
+1871	PF02006	DUF137		Protein of unknown function DUF137	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of archaeal proteins has no known function.	20.40	20.40	20.40	33.80	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.08	0.71	-4.89	37	143	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	140	0	96	140	121	174.20	52	69.07	CHANGED	LLhAcpPVISVNGNsAALsPcElVcLActls..AclEVNLFaRT-ERhcpIs-hL+.........cpGAp.cVLGhtsDs....pIPsLpppRupVspcGIasADVVLVPLEDGDRsEALhcMGKpVIsIDLNPLSRTucsAolTIVDNllRAlPplschsc-h+phscpcLppllppaDNcpsLpculctI	..LLLAcpPVISVNGNsAALsPcElVcLActss..AclEVNLFYRTcERhctIschLc.........c..p.GAp..cVLGltsDu....pIPsLpppRu+VspcGIapADVVLVPLEDGDRsEALs+MGKpVIsIDLNPLSRTA+sAolTIVDNllRAlPplschs+-h+p....hs+c-.LppIlpsaDNccsLpculctI............................	0	23	56	78
+1872	PF02363	C_tripleX	DUF139; 	Cysteine rich repeat	Bashton M, Bateman A, Yeats C	anon	Pfam-B_602 (release 5.2)	Repeat	This Cysteine repeat C-X3-C-X3-C is repeated in sequences of  this family, 34 times in Swiss:O17970. The function of these repeats is unknown as is the function of the proteins in which they  occur.  Most of the sequences in this family are from C. elegans.	22.90	1.00	23.60	2.50	22.70	-999999.99	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.68	0.74	-7.70	0.74	-3.51	166	2125	2009-01-15 18:05:59	2003-04-07 12:59:11	14	31	38	0	1234	2152	0	17.40	42	36.77	CHANGED	spCtstCps.sCps.pCsp	...................pCtPhCps..uCpN.GhCst...............	0	331	447	1058
+1873	PF02405	Permease	DUF140;	Permease	Bashton M, Bateman A	anon	Pfam-B_1126 (release 5.2)	Family	This domain functions as a permease. In Swiss:Q7DD59 it is involved in L-glutamate import into the cell [1]. In Swiss:Q8L4R0 it is involved in lipid transfer within the cell [2].	20.20	20.20	20.20	20.40	18.80	20.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.06	0.70	-4.85	267	4359	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	2463	0	1190	3158	944	214.40	33	75.29	CHANGED	p.phlp.phhplGhtol..........sllslhuhhhGhllulQshhtLpp.aGApsh....lushluluhlRElGPlloAlllAGRsGSAhsA-lGsM+lsEpIDAlcshGlsPlphLVsPRllAshlshPlLshlsshhGlhGGhllush..hhs...lssusahpphpp...hlsh.tDlhhu............llKuslFGhllulluCapGhp......s.puGspGVGpuoTpuVVtuhlhlllhDhl...lohhh	............................................h..hlp.phhtlGstol.........sIlsls.ulhlGh.V.lulQuhhhLsp...aGApsh.....lGhhl.uluhlRELuP....llsAllhAGRuGS.A.h.TA-lGsM+hoEplDAhcsMulcPlphLlsPRlhAullshPlLshlsshl.Gl..hGGhllush..hhG.........lssGsah.s.thps.....hl....s....h.tD.lhhu............l.lKuslFuhhlshlusapGap.......s..p.s.....ss.p.GlGp..AoT..poV..VtuhlsllslDhllohl................................	0	329	763	1012
+1874	PF02408	CUB_2	DUF141; 	CUB-like domain	Bashton M, Bateman A	anon	Pfam-B_1716 (release 5.4)	Domain	This is a family of hypothetical C. elegans proteins.  The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.59	0.71	-4.56	24	264	2012-10-02 11:50:15	2003-04-07 12:59:11	15	9	5	0	250	312	0	113.70	19	25.57	CHANGED	ssshsC.sssl..hstP.ssupPh.haPssasts.sssthssspsCsaplslPpGaaAplhlpsphss....psslpshDshuph...tthtssptpsa..aFssPphplslssssss.....sFuFplpW.shs	.........................s....tC...s.th..hs.s.......s.tsh...aPts.tts....s.hsths.ss.....sCsapl..s..lP....p.....G.....h..as..plp..lps.phps.......sshlplhD..sssph..................hh.h.s...s.s....t....p...sa.....ahsss.p...h..p..lpl..p...ssssss....pFthplpa.ph............................................	0	50	67	250
+1875	PF02410	Oligomerisation	DUF143;	Oligomerisation domain	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1798 (release 5.4)	Family	In yeasts, this domain is required for the oligomerisation of ATP synthase subunit 9 into a ring structure [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.35	0.72	-3.97	165	4456	2009-01-15 18:05:59	2003-04-07 12:59:11	10	15	4365	5	1086	2727	2020	97.70	36	72.41	CHANGED	hhphlspsl--cKA.pDIhllDlpp......ho...slsDahlIsoGsSs+plpAl......u-pltcph..+t...t......s.hpshphE.Gh..............................psu...cWlLlDh.G.DllVHlhpt-sRpaYsLEcLW	.....................................................................h..phlhcsl--pK.u.pDI.lslDlps...................ho.....sls..Dah..lIsoG.sS..sRp..VpAl...A-pltcph....+p..........t..............G...hpshp..h...E.Gt...............................................................s..su...cWl....LlDh.....G...D.....llVHlh.p.p-pRpaYsLE+LW................	0	374	701	924
+1876	PF02413	Caudo_TAP	DUF144; 	Caudovirales tail fibre assembly protein	Bateman A, Moxon SJ	anon	Pfam-B_1800 (release 5.4)	Family	This family contains bacterial and phage tail fibre assembly proteins [1]. E.coli contains several members of this family although the function of these proteins is uncertain.	26.50	26.50	26.60	26.60	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.69	0.71	-3.98	73	2529	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	606	0	168	1625	6	118.40	33	75.29	CHANGED	csppsapspshp......h.ps.s.hsp......................ssstls.....t......ssGpahhhss..thh.thhs........................ppphhppA-pp+ppLlppAsptIssLp..sslcLs.hho--EpspLptWpcYtshLs+.lDsosAsD......IpWPp.Pp	.......................................................................................................................a..tsht.hh.pt.h.hs..........................ssh.ls................s.u.ta..hhss...ph.h.t.hp..........................ttthh.ptA...Etp+..ppL..lptAsp..tIss..lQ.......stlc.L....s...hhT-EE.......p..spL.......pAWpcYtshLsp..VD.TS.s..APD......lpWPp.Pt.............................................	0	15	60	110
+1877	PF02415	Chlam_PMP	DUF145; Chlamydia_PMP; 	Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat	Bateman A, Yeats C	anon	Yeats C	Repeat	This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. Common for the Pmps are the tetrapeptide GGA(I/V/L) motif repeated several times in the N-terminal part. The C-terminal half is characterised by conserved tryptophans and a carboxy-terminal phenylalanine. A signal peptide leader sequence is predicted in 20 C. pneumoniae Pmps, which indicates an outer membrane localisation. Pmp10 and Pmp11 contain a signal peptidase II cleavage site suggesting lipid modification. The C. pneumoniae pmp genes represent 17.5% of the chlamydia-specific coding capacity and they are all transcribed during chlamydial growth but the function of Pmps remains unknown [1]. This family shows some similarity to Pfam:PF05594 and hence is likely to also form a beta-helical structure (personal obs:C Yeats).	20.60	12.50	20.60	12.50	20.50	12.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.18	0.73	-7.79	0.73	-3.36	528	2166	2012-10-02 14:50:22	2003-04-07 12:59:11	12	61	306	0	261	1592	95	25.80	43	6.13	CHANGED	slhFssNpu.....................................................tspGGAIhsp	........................................hhFssNsA........................................................................sspGGAIYs....................	0	105	137	231
+1879	PF02457	DisA_N	DUF147; 	DisA bacterial checkpoint controller nucleotide-binding	Bateman A, Coggill P	anon	Pfam-B_1846 (release 5.4)	Family	The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. This domain is the first and is a globular, nucleotide-binding region; the next 146-289 residues constitute the DisA-linker family, Pfam:PF10635, that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), which thus forms a spine like-linker between domains 1 and 3. The C-terminal residues, of domain 3, are represented by family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis [1].	20.60	20.60	20.80	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.46	0.71	-4.98	190	2847	2009-01-15 18:05:59	2003-04-07 12:59:11	11	19	2386	11	670	1835	550	121.00	38	40.57	CHANGED	lhpuhpthucp+hGALIVl...pcppslp..chhp.sGhh............lcuplosplLhslF...t..ssLHDGAlllps.scltuAushLPLops..ss...lspchGTRHRAAhGloEpo.DAlsllVSEEsGsISlshs..Gplh	...................................................hculphhucp+hGALIll..pc....sp...s.Lp....-hlp..oGh.......................lcu..closp.LLhslFh..s..oPLHDGAlIlps..s+It..s....Aush......LPLops..........st.......lo+-hGTRHRAAlG.l..SE.h...o....D.A.l.sllVS.EETGsISlshsGph.h..................	0	281	502	603
+1880	PF02520	DUF148		Domain of unknown function DUF148	Bashton M, Bateman A	anon	Pfam-B_1103 (release 5.4)	Family	This domain has no known function nor do any of the proteins that possess it.  In one member of this family Swiss:Q23614 the aligned region is repeated twice.	23.90	23.90	24.00	24.20	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.33	0.71	-4.29	45	259	2009-09-11 00:48:36	2003-04-07 12:59:11	12	5	28	0	213	215	1	107.00	20	48.61	CHANGED	pcsppcahsIlpN.psLThsph-splppWApp.u..lsspappFppphpspppchcpstsplIspLo....slpspLssIhsscs.TtppppptIpsLppphsp-.hsslhaltp....htpttt	...................t.pspppahtlhps..tslohsphppplptaspp.s...............lpsthppappph.psttpphppshspllspLs....ss.spLpsIhs...sps.Thppppptlpplh.pphs.c.h..l..lht.h....t..........................	0	69	84	213
+1881	PF02576	DUF150		Uncharacterised BCR, YhbC family COG0779	Mian N, Bateman A	anon	COG0779	Family	\N	20.20	20.20	21.00	20.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.69	0.71	-4.60	40	4207	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	4149	1	904	2603	1054	139.30	32	84.80	CHANGED	llpPllcshGhELhclchtpputthhLclhlD......p.-sG.lsl-DCpclS+tlSshLDs...pDPI..sp.tYhLEVSSPGl-RPLpptccFt+ahGchVclphp.shcsc+papGplhps-s......-slsl..phtsp....................plplshssls+ApL	...................................lpshlcshu.aELVclE..ahp...t....G....p....p.........hLRlaID..................................p..-..sG...lsl-DCsplScplSslLDs......................pDPI.......sp..tY.hLEVS.........SPGl.-RPLpptccat..chl..G..c.Vplp.L.....h..................s.........l..........p..........s...........c...+.......pa.pG..h..l..t..uh-s.................-plsl.........plcs..c...........................phplshspItKApl.................................................................	0	295	598	771
+1882	PF02577	DNase-RNase	DUF151;	Bifunctional nuclease	Mian N, Bateman A, Eberhardt R	anon	COG1259	Family	This family is a bifunctional nuclease, with both DNase and RNase activity [1]. It forms a wedge-shaped dimer, with each monomer being triangular in shape. A large groove at the thick end of the wedge contains a possible active site [2].	20.50	20.50	22.70	22.40	19.60	20.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.61	0.71	-4.95	112	1079	2009-09-11 06:46:39	2003-04-07 12:59:11	9	6	977	4	436	880	532	135.00	31	73.52	CHANGED	hp..ltGlshstss.s.....sslllLp-.p..sc.....+hLPIaIGthEApuIshsl...ps.hpssRPhTHDLhtsllpshshplccVhIsslc-ss.FaAplhl...p.psp.............t.h.................................plDARPSDAIALAlRss..sPIast-cVlp.puul.hp................t-c	....................................................h.plhslthp.sp.s...tssllLc-.s......uc.........RhLPI.aIGt.E.Apu.I.uhth.......ps....hp..s..s.RPLT.HDLht...s...l...lps......h......s......tp.l.pcVh..Iscl....p...-......us..FaAcLhh........p..pst..............................................cl.DAR..PSDAlALAlRss..sPIasp-plls.pu.ul.h..........pttt....................	0	176	335	404
+1883	PF02578	Cu-oxidase_4	DUF152; Cu_oxidase_4; 	Multi-copper polyphenol oxidoreductase laccase	Mian N, Bateman A	anon	COG1496	Family	Laccases are multi-copper oxidoreductases able to oxidise a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms [1].	20.40	20.40	20.40	20.80	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.59	0.70	-5.29	132	3547	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	3384	10	808	2592	2090	224.90	32	89.31	CHANGED	aoTR.........Gho...s.h.......tuhNluhp...s.sDs...ppVtpN....Rphlspt.....hshs............hhhhpQlHusplhhlpt..................................tssh.puDullTsp.ssl........slslhsADClPlLlh..D.psp..hluusHAGW+Gss....ssIstpsl.pth.pphss.......pspcl....huhlGPuIusssYEVu....p-Vh.ptF......tpthstttthhht............................s+hhhDLhthsptpLppsGlt....tpIth.......ssh........CThsp.s-.hFaSaRR.......psps.....GR.hhuhIhl	......................................oTR.....G..GlS........ssa............suhNluhp.....s...sDs...s..ttVtpN.......RppLhpt.........................hshs..........phlahp..QlHuscVhp.lst.............................................................stsh.puDAhhTsp..s.sl.........sls.lhoADClPVLhs....s.tpss.....h.lAA.sHAGWRGhh..............sGllcps.lp..h...t...p....ss...........................sspcl.............hAhlGPuIusp..sa..E..Vu....s-lh.ptF..................hs..t......s..p..s...t..s..h..h.h........................................s+ahhDLhths..ctp..Ltp.hGVp......pIhs.........ssh........................................CThs.......c.....tc......h.........FF..SYRR........ctpo........GR...hsuhIh..................................	0	252	508	672
+1884	PF02579	Nitro_FeMo-Co	DUF153;	Dinitrogenase iron-molybdenum cofactor	Moxon SJ	anon	COG1433	Family	This family contains several NIF (B, Y and X) proteins which are iron-molybdenum cofactors (FeMo-co) in the dinitrogenase enzyme which catalyses the reduction of dinitrogen to ammonium. Dinitrogenase is a hetero-tetrameric (alpha(2)beta(2)) enzyme which contains the iron-molybdenum cofactor (FeMo-co) at its active site [1].	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-10.08	0.72	-3.91	179	2027	2009-01-15 18:05:59	2003-04-07 12:59:11	12	31	977	14	943	1863	98	94.20	19	46.31	CHANGED	tsstls...tHFG...+uptFhlh...-ss....st.shc...llcsp.................ssstt......tsstphsp.hltp...pss..ssllsspl..GssAhttLppt.Glclhp..s....sssslc..-s.lpphhp	.............................................tttlstHFG+uptFhla............-lp...................st...php.......hlppp..............................hs.sss......................ssp...sp...hsp.hlpt.........ps....s..sslls.us..l..G.tsshptLtpt..GIclht...s....stsslc..cslpth..t....................................	0	381	689	831
+1885	PF02582	DUF155		Uncharacterised ACR, YagE family COG1723	Mian N, Bateman A	anon	COG1723	Family	\N	21.10	21.10	21.30	22.40	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.83	0.71	-4.36	92	875	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	488	0	565	818	18	175.80	27	42.95	CHANGED	plalF..p.aGslVhWshs................cp....ptpphL...phlp...................................phttp.hsppp....p.E-hpahhss.ph.....................................................................pspl...ts....................DhIh.Lpst...............................................................shhtchshSpuLupSs+LshhEpplsphl....-phpplsppLsp.sG+lsh.sc+......clhchhGclhth+hplslpspll.Dp.P-hhWc...cspL-tlYptlpchh-.......lspRlplLNc	..............................................................lFlF.p.aGslVhWshs................cp......pp.pphL...ptlp.................................................th..thp.l...sptphp..sEphpahhspph....................................................................................................................................pspl..hs..........D.hIh.L..p.st...............................................................shhhKlulSpuLAQSsKLuhaEptlsphl....pp..spslPppLu...p.sGc..l.sh..s+c............................plhpphGcLathRhplNL.puslL.Ds...P-haWc.......csp.LcslYptlppaL-lspRlplLN..............................	0	179	331	483
+1886	PF02585	PIG-L	DUF158; 	GlcNAc-PI de-N-acetylase	Mian N, Bateman A	anon	COG2120	Family	Members of this family are related to PIG-L an N-acetylglucosaminylphosphatidylinositol de-N-acetylase (EC:3.5.1.89) that catalyses the second step in GPI biosynthesis [1].	22.00	22.00	22.00	22.40	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-11.03	0.71	-3.63	137	4157	2009-09-13 21:13:25	2003-04-07 12:59:11	12	36	2321	19	1451	3457	1554	136.10	25	45.05	CHANGED	LllssHPDD-s.husGusltphtp.....p..Gtpltllsl.........os....G...............................phs........................phsth..Rpp......EttpA.s.phL.Gl........pphhhLs..........hsDsthpt........................................................hpphhpt.....ltpll...pph...p...P.........................cl.......lhsht....stss....................HsDH.psst.....t..hshp...uh	....................................LslsAHPD..D-s.hus.u.u.o.l....u....p.hsp..............p......G.h..pV..t..l.l.sh............Tp.........G...................................................................................................ph.u.p................................................phsth....Rcp.............EhppA.s..chL..Gl..........................pphthLs.....................h..D.sthtt...................................................................................................hpph.tpt............ltpll........cch........p...P......................................................sl.........l.h..o.ht..stss....................HsDH.htstpsshtA.h......................................................	0	554	1008	1293
+1887	PF02586	DUF159		Uncharacterised ACR, COG2135	Mian N, Bateman A	anon	COG2135	Family	\N	27.10	27.10	27.20	27.10	27.00	26.80	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.88	0.70	-4.80	164	2412	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	1845	9	843	2126	1620	208.00	26	88.83	CHANGED	MCG..R...asht......ts...ppltphhth................................................ttphtspaNls....Psptssllht................................................................tpt..............................h.phhpWGl.....h....P...tasc...........................ththhNARsE...............o.l..tp..+s..sF+....psh...pppR.CllPusGa....YE......Wp......................tttsp.......K......pPah.....l...........php...s......t..ps...............................................................................................................................................hhhAGlap..tapss.tt............................................................htohsllTssu.......sst.....lstl.Hc..................R.MPllL..s.t-phcpWL.........pstssttpt....h......................lsttsspstpsss	...............................................................................................................MCGR.....as.t......ts......pphht.hh.t.................................................ssp.....sp.aNlu..Psp.s.llhpp..............................................................................ptth..................h..p.hpWGh.h......P.........sWhc..............................t..hhN..ARsE...........................Th....tp......p...hF+.....tsh....ppp....RCllPssGaaE...Wp..........................ttssp.......K..........pP.aa....l........................pht......-.............s...p..................................................................................................................................................................h.hhAGlap......phts...tst.......................................................................htshsllTssA....stt.......................lstl.Hc..................R....hPllL.......s...-..t.h.cpWL.........ssp..hstttt.....h.......................................................................................................	0	251	500	686
+1888	PF01519	DUF16		Protein of unknown function DUF16	Bateman A	anon	Pfam-B_764 (release 4.0)	Family	The function of this protein is unknown.  It appears to only occur in Mycoplasma pneumoniae. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils [2].	25.90	25.90	26.00	31.60	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.55	0.72	-3.80	18	91	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	5	3	30	66	0	93.90	42	69.63	CHANGED	sFsGshsc..Kt.p......ocYVT+KQFs....EFK.D.........uscp+LpKlEscls...........tQGEQIpp.................................................QGEQIccLp.p.c....................................t.scsLplllpoLpphs.......cRLD+lEu	...........hsGshsc..+hp.......scYVTpKphs.......EaK.s..........uspQcLhKlEspls..................sQGEQIsplhphVpt..............QGEQI+pLphc.K....................................sQGcoL.p.IhpsLtthscRLDph-......................	0	30	30	30
+1889	PF02589	DUF162		Uncharacterised ACR, YkgG family COG1556	Mian N, Bateman A	anon	COG1556	Domain	\N	20.40	20.40	20.40	21.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.04	0.71	-4.78	209	4142	2012-10-04 00:26:15	2003-04-07 12:59:11	10	12	1994	1	981	2994	341	198.50	23	58.26	CHANGED	lpp.htcplppts.splhhsps...........hp-shphltclltpt...sh.................................sh.shphsl.tchhl.............hshlctsptphhchhstph......................tpthtcphhpuDhu..........lousshulA-oGslslhsspust.chhshhPpthlsls.....sh.s+lV.sshpcAhptlph.....ts.t.........th.sshsshh.................sGP.ucsu-lphhh.hshp...GPp.clpllll	......................................................................................................h..phtpphpp.s.spVhhsps.........................tp-.ssph.l.h.p.lh.pcp...ss..................................................sh.sh-scL....sEhhl......................hssl.c...p.s...p..t.p.l.tchhppph...........................................cp.phc.cp.hh.pA..-.l.G.........lousshulAEoGolsl.ssspGs.......u..RhhshlPcsplslh.....sh.p+ll.sshp-shthlph......suhu...........p.phsshhshl..................oGP..pp.s.u.Dl-..................G.Pp.chpllll....................................................	0	354	721	864
+1890	PF02590	SPOUT_MTase	DUF163; 	Predicted SPOUT methyltransferase	Mian N, Bateman A	anon	COG1576	Family	This family of proteins are predicted to be SPOUT methyltransferases [1].	20.90	20.90	20.90	21.20	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.79	0.71	-4.50	30	3767	2012-10-01 22:53:19	2003-04-07 12:59:11	12	4	3656	18	737	2319	968	152.30	38	97.90	CHANGED	M+IpllsVG+hppcalcpuhsEYtKRlspasp......lcllEltsp+t....pspshpphhccEupplhtpl..tssshllsL-hcGKthoSEphAchlcchthpGppclsFlIGGutGLssslhpcAshphShSchThPHpLhRllLsEQlYRAasIhpscPYH	.................................................M+lpllsVG+h.t..tcalppuhsEYhK.Rhsch.hp......h-llElsstKt......spstchp.p..lh.c+E..G..pp.lLutl..............ss..p..s.h.l.l......sL-lp.GK.thsS.phAp.pLppht.h........p.G.p...clsFlIGGu...G.Lu.s...slpp...p...A.s.........p...lShSphThPH.p........LhRllLsEQlYRAasIhpscPYH.............	0	246	481	623
+1891	PF02591	DUF164		Putative zinc ribbon domain	Mian N, Bateman A, Eberhardt R	anon	COG1579	Domain	Structural modelling suggests this domain may bind nucleic acids [1].	23.70	23.70	23.80	25.90	23.40	23.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.02	0.72	-4.14	93	1089	2009-09-12 00:25:18	2003-04-07 12:59:11	10	5	1080	0	327	812	391	56.40	33	22.61	CHANGED	llptY-+lRpp..pGhulstlpps....sCtGCphplssphhscl.pps..cc..llhCspCsRIL	.......llphY-+lRcp..pu..huls.lpp.p.......sCsGChhplsspphtcl.ppu......cc...llpC.pCGRIL........	0	138	262	312
+1892	PF02592	DUF165		Uncharacterized ACR, YhhQ family COG1738	Mian N, Bateman A	anon	COG1738	Family	\N	22.00	22.00	22.70	22.40	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.71	0.71	-4.02	151	2443	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	2235	0	513	1577	1908	145.40	33	64.21	CHANGED	shGslhaPhsFlhoDllsEhYGtptA+cslhhGahsslhh.hlhh...hhhh......hhs.ss.................................tshttlhs.....ssRlslAShh.AalluQhlDlhlashl.....+phtt......tp............tlWh..RshsSThluphlDThlFhs.lA..Fh......u............h...........hs.............hsthhslhhssalhK	.......................................................................ThGshsFPhhFLsTDlhsclaGtphAR+llahshhssllh..hll...lhh......hhs..h....h.............................tultth.hh.......lsRIAlAShh.AYllGQhlDlhVFs+l+pt..........+............paWl.tshuSTlhGshlDTllFhs.IA...Fh..t......................s............h..........................sppahplslssYhhK....................................................	0	152	307	420
+1893	PF02593	dTMP_synthase	DUF166;	Thymidylate synthase	Mian N, Bateman A, Eberhardt R	anon	COG1810	Family	This family catalyses the synthesis of thymidine monophosphate (dTMP) from deoxyuridine monophosphate (dUMP). The physiological co-substrate has not yet been identified [1].	24.40	24.40	25.20	24.40	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.46	0.70	-5.00	24	85	2012-10-10 17:06:42	2003-04-07 12:59:11	9	3	45	0	68	91	5	224.40	30	91.77	CHANGED	sllhp..GpaGcRhhpslhscsphp...........................lhlh-hs-..pls-hI-pscphL.p......l.-sDlllshsLHPDlshtLschhtp.sshtulIlsutssc....h...pl+cph-phshphhsPc..hCsLc...........sspshlccFsch..FGpPclclplp...sscl..pcVcVlRuAPCGuTaalAccltGhsls-hthps........uhthpp...YPCtAuhth..p.p-shlHpAGhltpcAlpcAlth	......................................llhc..GpaGcRhhpsltppsshs.........................lhhhchsc....tls-hI-p.P.c-h.Lsc......l.cuDlllshslHPDlshtLschh.....pc.ssscul.Ilsutpsc........pl+cphcphshphhsPc..hCsLcc...........stpshlccFlch..FG+Pcl-lplc.....ss..pl.....pcVcVlRuuPCGoThalA+clhGh.....plp-ht.ps........uhthpp...YPChAuhth..p.s..-shhHpAGhlt+cAlccAltp........	0	16	41	54
+1894	PF02594	DUF167		Uncharacterised ACR, YggU family COG1872	Mian N, Bateman A	anon	COG1872	Domain	\N	22.60	22.60	22.60	25.40	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.22	0.72	-4.05	29	1679	2009-12-08 16:16:35	2003-04-07 12:59:11	11	3	1585	3	582	1119	107	76.30	39	73.13	CHANGED	pppslhlplcVpPpupcsplsulpsp.....pLclplpuPPhcGKANpcLlchLu+hhpls+SslplhpGppSRpKhlhlps	................s.sslhLplhlpP+...Au..+..ss..I.s.Glcs-.........plKVslsAPPlDGpANscLl+aLuK.thcVsKSp.Vslt+GchuRc.KplcI..s............	0	177	345	468
+1895	PF02596	DUF169		Uncharacterised ArCR, COG2043	Mian N, Bateman A	anon	COG2043	Family	\N	20.20	20.20	20.30	21.30	18.20	17.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.27	0.70	-4.95	76	379	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	254	0	211	370	56	210.60	21	82.60	CHANGED	sppLtchLcLctpPVAV+hh.t...............................spc.hst....shp..ttthp..............aCphlth.AR.pG.........cshhh.ss-phsCssGusshGhtch.st...........lpsG........................phhhp.hthhps.csuc+hhcp.hPpl...ttphhullhuPLpc.ssh.....p.P..DllllhssPtQhhplspuhhYtpGs.phpsshsuhpusCu-ssshsh....hpspss.hslGCsGsRthut.hp....ccElshulPhptlpclhcsL	.......................................................s...l.phlpLptpPlulphh.........................ppp..st.....th.......tt.hp...............hC..ph..hth..Ap....p.G.........pshhh..st-s...h...s..C.huGthshGhtph.sp.............................hlpsG...................................thhhp....thhpo.-tucchhpp..lshl...tsp.......h..tslhh.u..P.Lpc..hph.....-.P....Dl..llhhssPtphhtLsps...hhappss..hpsshssht.usCusssshsh.....ppsp.s..hslGshuspthst..hp....s--hshulPhpphpchhpt.........	0	81	158	191
+1896	PF02598	Methyltrn_RNA_3	DUF171;	Putative RNA methyltransferase	Mian N, Bateman A, Eberhardt R	anon	COG2106	Family	This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA [1], and may function as a methyltransferase [2,3].	18.60	18.60	24.50	20.90	17.90	17.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.85	0.70	-5.06	23	418	2012-10-01 22:53:19	2003-04-07 12:59:11	12	7	347	2	286	396	27	273.20	32	79.92	CHANGED	slSlslPsSlls..sspshc.tTahsupIARAsslFsVsEIlla--.....................................................tp..tstpptps.......shhlsplLpYhtTP.YLRKplF...shpspL+aAGlLPPLssspHh..ppscptcaREGlslchspps................................phlslGhsc.ltlcp....tls.ssRVTVchps................tplVsPscsps.....thYWGYpVR.hspshuclFppssh.tGaDhslhsScpupslspsphphh...........................shtplLlVFGth...........ptttps.ppsc......tpspthFDt.l.NssPsQsspslRsEEAlhlsLuhLp	..............................plSlslPuSlls.......ss..ps.....c.+ThhsGpIARAsslFpV-Ellla--....................................................................................t..t....tt..p..tps..............sh.hlsplLpYh-sP.YLRK.......tlF...........Ph.+p.sL+huGlLsP...Lc.sPaHh.......pps....c.......scaREGlslpt.ssptt.t..................................shVshGh.p..c....lplsp...................tl..ss.hRVTVchsp.......................................spl..Vssppscp...thshYWGY......pVR.hs..s..sL.splhsc.ssh......t..G...YDhsIuTS.c+Gp.sl.s.ps..t.ht................................php+hLlVFGs...................................pshtts.pt.p...............st.psp.hFD..hhl....Nss.P.sQ..GocolRTEEAlhlsLshL........................................	1	82	155	230
+1897	PF02604	PhdYeFM_antitox	DUF172; PhdYeFM;	Antitoxin Phd_YefM, type II toxin-antitoxin system	Mian N, Bateman A, Eberhardt R	anon	COG2161 and [1]	Domain	Members of this family act as antitoxins in type II toxin-antitoxin systems [1].  When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin [2].  This domain complexes with Txe toxins containing Pfam:PF06769, Fic/DOC toxins containing Pfam:PF02661 and YafO toxins containing Pfam:PF13957.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.24	0.72	-4.39	156	5612	2012-10-03 00:18:00	2003-04-07 12:59:11	14	16	2448	47	1340	3995	616	70.50	18	79.79	CHANGED	hptlshs-h.+sphupllcpsppspp..llITccGcs.ssVllsh.....ccacphpc...phthhpt.ttspphtp........tthp..ts	.....................hhsho-h..+pphspllcpspps.p.....p....l.hI..o..p..p..s..c....s...s...sll.lsh.....................cpapp.h.p.......t..h.t....tt.............t.......................................................	0	421	912	1136
+1898	PF02616	ScpA_ScpB	DUF173; 	ScpA/B protein	Mian N, Bateman A	anon	COG1354	Family	ScpA and ScpB participate in chromosomal partition during cell division. It may act via the formation of a condensin-like complex containing smc that pull DNA away from mid-cell into both cell halves. These proteins are part of the Kleisin superfamily.	23.70	23.70	23.70	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.71	0.70	-4.79	11	3012	2012-10-01 19:44:35	2003-04-07 12:59:11	9	6	2925	0	778	2298	2016	209.20	27	81.05	CHANGED	Llpctclssa-VslsclT-pYlphlcph.ppL-Lch.......sschllhAuhLlchKucsLLs....tpp.-p..-.t....phc-thhtcL.....h+tttc.hcchchpth...tphs+c.sshcchlctlcc...th.cl-c......shht.htth.hh.c.thtsthcchp.........p.hclslE-phpELlt.............p.h.tl...s.hhsa.pLh............hshhclVssFlALLhLhpsptVplpQc-.au-lhlphh	..................................................................................................................................LIp+pclDIhDIslsplT-QYl.....s.....Y.......l......c......p......h.....p.........p..........h.........cL..-l...............................AuEYLVMAApLltIKS+hLLP...........p..t.p....t...p...p.......t....-.......t............................-s.....R.p.-.....L..l...p......c.L.h..-.Yc..p...a....K.th..u.....p.t.L.pp.h..t....ttt..........has.+.t......................p..p..h..h..p..t....t.............t..l.p...........p..h..c...L.h..h..A..h..tp.l...hp.+.t......p.h.pph.......................tl...s...l.cp.p.h.p....p..lh..t.....................................h........t.....t....p......hhpFp.p.L.h.p.p................................tps.t.t.t..l.l..sp..FLAlLELhKpthlpltQ.p.c..sassIhl...t.......................................................................................	0	264	526	667
+1899	PF02617	ClpS	DUF174; 	ATP-dependent Clp protease adaptor protein ClpS	Mian N, Bateman A, Moxon SJ	anon	COG2127	Family	In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins [1].	20.00	20.00	20.10	20.10	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.71	0.72	-4.26	194	2895	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	2572	47	893	1937	1064	79.80	36	28.96	CHANGED	hcps..shY+...VlLhNDDaosM-FVlplLpphF.phsp-pApplMLpVHpcGp.uls.ulhsh-lAEs+spplpphu......pttth.........PLpssh	...........h.p.PshY+VlLhNDDaTsM-FVlpVLpchF...s....hs.........h-cAsplMLpVHppG+..uls.G.l.a.o.t.E.lA.EoKstp.Vpphu........+ttta.........PLhssh.......................	1	268	550	744
+1900	PF02618	YceG	DUF175; ADC_lyase;	YceG-like family	Mian N, Bateman A, Moxon SJ	anon	COG1559	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of Swiss:P28306 was solved by X-ray crystallography.	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.01	0.70	-5.39	195	4001	2009-09-21 13:22:03	2003-04-07 12:59:11	11	7	3759	2	892	2962	1446	281.50	30	77.07	CHANGED	htlplspGsohppluppLpcpullpss........hh....F.phhs+hp..stssp.l+uGpYplpss.hostpllptL..spG........................................................csht......h.plTlsEGhshpp............lhptlsp.........pshh..tp.t......t.tp........htphst.................EGhLaP-TYpa.stss.......ospp.llpphhpphp...phl..tpthppcs...................ttl...sh.osh-hlhlASIlEKEsu.hssERshlAuVFhNRLc.p.......GM.....pLQoDPTVlYu..l...tt.......tt............plppp...DL.c.ts....oPYNTYthpGLPPsPIusPGpsulpAAlpP.spsc.....aLYFVA...c.sc..........Gs..HhFopThpEHppsV...pcY	.............................................h..lpl.tGsuhpplupp.Lpcpsl.lpss....th.....F...phh.h...+.h......p.......s......h...sp....l+uGp.Yp.l....pss.hosp.cllphL.....pp.G........................................................c.psp...........h..plslsEGh.sh.pp..........................hhptl.tp..........................tshl.......ppp..............hpp....th.h...t.t...h..tt.ph.s.ph..............................EGhhaPsTYp.h..st.....ss............o..s.p..llcphhpphp.....ptl........pph.h.t.tp.t.............t.sh.....sh.s..phlhlASllEKEs....u....h..s.p.-.RshlAuVFhNRL.p.t.......sM...........hLQoDsTVlYu..h........sc.........p............t...plppp.............Dl...c..hsoPYNT.Yh.h....sGLPPsPIssPuhsulcAuhp.....P....spo.....s.......aLY..FVA...c..ss........Gs..phFup.shp-HppsVpc................................................................................................................................................	0	308	608	762
+1902	PF02620	DUF177		Uncharacterized ACR, COG1399	Mian N, Bateman A	anon	COG1399	Family	\N	21.30	21.30	21.50	22.20	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.80	0.71	-4.06	181	3846	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	3794	0	853	2473	744	115.20	24	64.04	CHANGED	lpuplpu..slphsCsRCLpshphslphp.hphh.h..h...sppt..tt...............................--..thhh.............sstp............lDLtphlp-pllLslPhtshp.....p..sCps..hsststs..tt.........................tt.........s....P.....a.usLpsL+	....................shplpsslsl.CsRCLcP..hp.ht.lphs.hs.h..h...ht...sppp....tpt...............................................-s.psl.l............cpsp.............lDLtshlcDpllLslPhtslpp........-.....cCps.....h.s.s.s..ss..p...hsct...................................p...pp.ps.................s......P.....a.AsLtsL........................................	0	270	558	726
+1903	PF02621	VitK2_biosynth	DUF178;	Menaquinone biosynthesis	Mian N, Bateman A, Eberhardt R	anon	COG1427	Domain	This family includes two enzymes which are involved in menaquinone biosynthesis. One which catalyses the conversion of cyclic de-hypoxanthine futalosine to 1,4-dihydroxy-6-naphthoate, and one which may be involved in the conversion of chorismate to futalosine [1]. These enzymes comprise two domains with alpha/beta structures, a large domain and a small domain. A pocket between the two domains may form the active site, a conserved histidine located within this pocket could be the catalytic base [2].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.28	0.70	-5.18	131	1044	2012-10-03 15:33:52	2003-04-07 12:59:11	9	3	556	15	368	1003	282	248.00	24	91.99	CHANGED	lplGtsshsNsh.haauL.........................ths.hchhhssspsLNphhh.puclDl..uhlSshtasphtccYtlLs..usuuhGpshuslllu..................p....t..tt.....plAlsupssTushLh+lhh.pt........phh.hs....cl..thhpst......DA.........ullIt-stl..................satppth....hhlhDLGchWpchT.G..LPhshuhhsh++s.hs.....phhtplpc.slppShphuh..pphpphhph...hhcpsthh.......pp.hlphYls.phohslupctppulcphhphutc	.......................................................hplup.shhNsh.hahul..............hpht.......ths.hc.h...h.h.ss...s...pp.LNchhh.....p..s...c..l.Dluhl....S....h....h....t..h..sp..h....h....c....c...Y.t.l.L.......ss.s..u....hG..c..sh..usl.lls..................pp....h..t...hp...........................plAls.u.....p.ssT.ushL.h+..lhhtct...................phh.hs......pl....h.hpst......DA............................ull...It...-..ptL.....................pa.t.p.p..h........phhhDLuphWp...-..h.T...u.....LP.......h.s..hu..shsh++s..h......................shhtplp.ctlppuhph.u....pp.p...hlhph....hh.cppt.hp...........pphlph.Yh..s...phsh...sl..u...p..pphtAlcphhchsh.t...................................................	0	156	292	345
+1904	PF02622	DUF179		Uncharacterized ACR, COG1678	Mian N, Bateman A	anon	COG1678	Family	\N	20.60	20.60	20.60	20.70	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.22	0.71	-4.61	181	2362	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	2224	7	628	1535	1045	160.00	35	76.37	CHANGED	hP.s..hsDspFp+oVlalC....cHsp.c.GAhGlllN+..Ph..s....lsls-llppls.........h................................ttph..............sVahG....GPV.ptc+....GF...lLHss..t............t....ts.............ol..pls...s.....slhlTsohDlLps...lupu.tu.....PpchllsLGYAGWusGQLEpEl.tpNuWLsssAssc..........llFss.s.pp...+WptAhpplG	......................................................................................................................................hPshpDshFpRSVlYlC....-Hsp..p.G.A....h.GlllN+..Ph..s......l.sl..psl..Lpplph.s..........................................thcp.....................................sVhhG......GP..l..pp-R.......GF...lLHss.tt......................h......su...................................................ol...pls.......s..sl.s.h...T...s..o.tD.lLcs....luss....tt............PpchllsLGYAuWst..GQLEpEl.tc....NuWLsss.A.c...s..........llFs....s....shtc.......+WppAhphlG.....................................	0	200	399	525
+1905	PF02623	FliW	DUF180; 	FliW protein	Lima T, Mian N, Bateman A	anon	COG1699	Family	The protein BSU35380 from Bacillus subtilis (renamed FliW) was characterised as being a flagellar assembly factor. Experimental characterisation was also carried out in Treponema pallidum (TP0658).  In Campylobacter jejuni, Cj1075 has been shown to be involved in motility and flagellin biosynthesis. The two paralogues in Helicobacter pylori (HP1154 and HP1377) were found to be able to bind to flagellin. FliW proteins are involved in flagellar assembly [4]. FliW is part of a three-part feedback loop: in Bacillus subtilis FliW inhibits CsrA (an RNA-binding protein) which inhibits FliC translation; hence FliW is required for FliC (flagellin) production [5].	25.00	25.00	31.20	29.20	24.60	23.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.40	0.71	-4.55	83	725	2009-09-10 21:46:53	2003-04-07 12:59:11	10	3	652	2	212	534	71	119.40	31	84.43	CHANGED	lpF.pGl.GF-.ph+cFhll.....ppsssFhhLQSl-ssclu..FlllsPathh.-YchclscpphptLplpstp......-lhlhsllol.....tss...hcchTsNLtAPlllNhcsphutQllL.psscYsh+a.lh	.......thppsIhGFE.ch+cahlh.........ptcpsFhhLpSl-....st...s.lu..FlllsPahhh...-Y..ch...cl...ssthhphLpl.ps..tp................c.lhlhsIlsl........sps........hccsTl..NlhAPlllNhcsphutQllL.ssspYshpa...h...................................................	0	108	182	198
+1906	PF02624	YcaO	DUF181; 	YcaO-like family	Mian N, Bateman A	anon	COG1944	Family	\N	25.00	25.00	25.40	25.00	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.89	0.70	-4.95	127	1709	2009-01-15 18:05:59	2003-04-07 12:59:11	11	25	1462	0	432	1316	83	324.50	28	58.87	CHANGED	ssGKGtottp.ApsSAlhEulERauuth.hst.................hthtpshtph......ttts..lsspshhhhsppph.....................hs.st.lp........Wh................shsltss.....c.plhl..Ptsh...httsh..................hhh..sS...NGhAuGsohcEAllpulhEllERDuhslh.....hhsp...hshspl..........shss....thstlhpthpp...tG..hclhlhDho.......-h.slPshsuhh....................hpssssthhhGhGu+hsschAltRAloE..hsQsthhhh.ttstpp.....................................p.tphtphhshsphttt..hhh...t........sphphsshs.............s.tsslptl.lstlpptGh-.lhsl.Dho......h.clG.lsVV+lllPGhp.	...............................................................................................sGKGsopcs..Ahs.SALuEhhERhusshhhs-...........................hhhtpslsst...............................shs.pass-pah..t...................................thac.P.-scls.................hs................................shhc....s...cs......p..slal..Phsl....lsshas..........................S....NGhuA....G.NohpEAhlpGL.E.lhERtshsth..................................hhpp......lslPcls.........s.shs.chss.l.hctlpph.p.t.pG..aslhshDso......h..ss..th.P.Vl.ssll....................hsssssssh...suhGAH.sDhtlALcRslTE...l...h....QuRshps...h.sshssssh....................................stcchsc..ht.shpp..p..hhcs.stlh.....t........httt.....schsas-hs............hss.ss.p.c-hssL.hsh.hppt.sh-..lhls.Dhp.........cl...G...lhssRllVPGhp........................................................................................	0	120	256	346
+1907	PF02636	Methyltransf_28	DUF185;	Putative S-adenosyl-L-methionine-dependent methyltransferase	Mian N, Bateman A, Moxon SJ, Eberhardt R	anon	COG1565	Family	This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase [1,2]. In eukaryotes it plays a role in mitochondrial complex I activity [2].	23.20	23.20	23.50	24.00	23.00	22.70	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.82	0.70	-4.98	157	1692	2012-10-10 17:06:42	2003-04-07 12:59:11	12	15	1433	3	694	1556	1906	243.10	24	62.15	CHANGED	hluhhhhphapph....s...ts.......hpllEhGsGpGpLhsDlLpshp........ph.P.ph.....htt..hphhllEhS.............stL+phQpppL.................tt...................................hsh.....W..hc.pl..t..ph.s...................hsslllANEhhDAlPl+phh.................................hpsss..a.pEthVshs.......................................ss................th...ths..h.ts....................htshltphthth...............................tGhhsElsssstshhppl...upplsp....................................................GssLhlDYGh.stpp...........hssTL..puh................ppHpht.........s.sh...tpP.GptDlTAHVDFssL....tpsu.pt.G...hpshuhs	.............................................luhhhhp.hpth......t........t............hplhElGsGpGpLhtDlLptlp.........ph.s..th.....htt...hphhllEhS..........................spL.pphQpp.p..L..........ps........................................................htt.l.t.W....hp..pl..ph......................hsshlluNElhDAhPlchht......................................................................psptt.......h.hEhhVshs............................................................................ts............ph.ths.....h.tsh.t...........................tth.l..pht.th..............................................tsth....h..Els..tttthhppluptltp.....................................................GhhlhlDYGh..tst.............................psoL........puh..............................hp.Hchh......................s.sh.tts....G...ptDlTucVcFstltphs.pt.s..ht.....h............................................................................................................	0	221	439	583
+1908	PF02638	DUF187		Glycosyl hydrolase like GH101	Mian N, Bateman A	anon	COG1649	Family	\N	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.14	0.70	-5.57	4	1510	2012-10-03 05:44:19	2003-04-07 12:59:11	10	34	1000	0	288	1415	225	300.00	32	62.31	CHANGED	clRGVWlssVsslca..............spsQppphIshLcclp...hNTlaspVhssGpsLYPSthu..Wpshhssp.ttD.GhDsLu.hI-cAH+RshcVhsWF...chuhpss.....shschlcpHPthhh.p+pDhsts.....GsphahsPhhPEVQsaITpllh-lVp+YDlDGVQhDDaFh.spphG.-..s.uhYcQ.st.sshus.cD..................WRpsplsphltplstpIKAsKPslphulSPsssa.N..............huYsshhtDhpcWlcpGllD.lssQlYhs.hut.suthphhuhh.ocplhPssVtlhhGlsshpls.s..p.-ssWss	..............................................................hRuhWlsoV.....p..h..-.aP.................hpt.p....pp...t....h.l....c...h.L...c...c...lpt.....thNsVhhQV.+.P.s.usAl.asS.p.......h.........h......P.......W.............S...........p..h....h....T.......G..........p........G...p.....s..P......G......aD.P..LtFhl-EAHK.R....G.....hc.lH...A...Wh...............hch...s....h..s.sp............p.h.s..p....h..h...s...p...p..Ps......p....h.h......p.....+.....-..h.......l.....h.s..........h...................................................u..s.......p...h...h.ls...P....GlPE.V.pcalsslltEl..Vp+.Y....s....lDGl..p..hD........D......Y...F...Y..............h......p............s.....s......G.........t......p.....h...s.....D......p.....p........s...a.p.p...Y..s.......t.s..h...s.s..h..s.D....................................................W...R...RsNs.pp...l...lpclppsl.K....s...h...K....P....t.........VcFG..l.S..P.h.Gla..s.tpc...............................sptGhtsY-.p..Y..AD..sppWl....p.p....Gh...lDYlsPQlY.W....s.........h.sh.....s........u......t........ashlhpW...W..s.p..s.....t..s....p.....h......tLahG.sh.hph....................................................................................................	0	98	206	262
+1909	PF01579	DUF19		Domain of unknown function (DUF19)	Vogel B, Bashton M, Bateman A	anon	Pfam-B_402 (release 4.1)	Domain	This presumed domain has no known function. It is found in one or two copies in several Caenorhabditis elegans proteins.  It is roughly 130 amino acids long. The domain contains 12 conserved cysteines which suggests that the domain is an extracellular domain and that these cysteines form six intradomain disulphide bridges.  The GO annotation for this protein indicates that it has a function in nematode larval development and has a positive regulation of growth rate.	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.95	0.71	-12.01	0.71	-4.25	47	383	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	8	0	378	354	0	150.60	15	67.46	CHANGED	sCsststh.........pshpCh....h..htphtpphpthshp....ptsphpphppsCsshhpChpshpC.......tt....hp.h.thCphh.ah.stpa.pChsKlts.......ptspChpsat...........ttptpphtpcsCpthhupc.sCh...........cctl.ppsCGp...pphptatsphh...........thsshhhp.pCshp	..............................................................................pCh.....h..htph.t...tht.t......hs..t.........pthpphpphCp.....p..h.h.pChp.sh..p..C....................t..p.hp.htt...h..C.p.hh.ah.sp.p.a..t.pChp....Klts.........p...pp..sCh..psa.....................................pptt...pppptC.p.thhspp.sCh...........cptl.pphCup...pthptatpph.................................h...................................................	0	97	120	378
+1911	PF02643	DUF192		Uncharacterized ACR, COG1430	Mian N, Bateman A	anon	COG1430	Family	Two structures have been solved for members of this large (>500 members) family of bacterial proteins present mostly in environmental bacteria and metagenomes (distant homologues are also present in several Plasmodium species).  TOPSAN analysis for pdb:3pjy shows that there is much similarity with the other solved structure, pdb:3m7a, solved for UniProt:Q2GA55 (Saro_0823), a homologue of Thermotoga maritima TM1668, UniProt:Q9X1Z6., The homologue in Caulobacter crescentus (CC1388), UniProt:Q9A8G6, is associated with CspD, a cold shock protein (CC1387), UniProt:Q9A8G7. However, the genomic context of UniProt:Q2GA55 is most conserved with a putative xylose isomerase, suggesting a possible role in extracellular sugar processing. Saro_0821, UniProt:Q2GA57, is annotated as an AMP-dependent synthetase and ligase. PDB:3m7a structure corresponds to the C-terminal (27-165) fragment of the YP_496102 (Saro_0823) protein and it is structurally unique, as the best hits from Dali have a Z-score of 3.8 (1nt0, 2j1t, 3kq4) and it is thus a likely candidate for a new fold. Interestingly, many of the top Dali hits are involved in sugar metabolism. There are no obvious active site-like cavities on the protein surface of 3m7a (http://www.topsan.org/Proteins/JCSG/).	20.30	20.30	20.70	20.50	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.23	0.72	-4.36	180	1078	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	966	4	459	1048	876	105.70	30	67.60	CHANGED	shplElAcTstpRtpGLMhRpsl..........ss...sp.GMLFsa..s.......psph.tsFWM+NThlPLDllFlspsGplhslppts......Pts..tss...h.ssh...........s.sph....VLElsuGhhpphulpsGcplph..	..................h.hplElAso.tpRtpGLM..aRpsl..............st...sp.GMLFla......s...........psph..tsaWM+NT.lPLDllFlcscGp.....lhslpc.t..........Phs.....ps.......h.sst.............................ts...spa......sLElsuGhhtchGlpsGsclp...h............................	1	129	301	397
+1912	PF02645	DegV	DUF194; 	Uncharacterised protein, DegV family COG1307	Mian N, Bateman A	anon	COG1307	Family	The structure of this protein revealed a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that this family has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism [1].	20.30	20.30	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.61	0.70	-5.33	45	5275	2012-10-02 12:41:15	2003-04-07 12:59:11	11	9	1863	22	831	3515	181	269.70	26	95.33	CHANGED	clsIlTDSousL.s..t-hhcchslpllPLslhhss.csYpDsh..-l.s.cphhcchtpptphPp.TSQPssschtchacc.hhppua-tllsltlSStLSGTapsAthusphh.....shc..........lpllDSphsuhu.GhhVhcAuchhcpGt.shc-Ilpplpphppcp..psahsVcsLchLh+GG...........RlupstuhlGsLLslKPllphcc..GplpshsKsRupK...KAlcclhc.....l..ttptsstthhclslhaus..st.-puppltcplps..phst..ch.hsthuslIusHsGsGululshhhc	.....................................................ltllTDSos.s..l.s....t..c.h.h..c.........c....h....s....l..p....l....l....PLs.lh.....ls....s.....p...s...Y...h...Dsh..................sl..s.c...ca...h.p..p..h.....p..s...p..p.h.P.p..T.....SQPshupahchacp...htp..s.h..s....p..lls.lpl..SusLSGoaps...Ap......u.s.p.h...............shp...................lpll.DS.phs.uhuhuhhlh.pA.s...c..h...h.pp..Gt....shc..-.l..l.ppl.p.p..h.pp..p.s..phah..hlss.LcpL.....h+GG...........Rlop......ssuhl...G..s...L...LsIKP..l..l.p..h..p..c...GpltshpKs....Ru.....p..K.....+..u..h..pplhc.................................hh..........p.pht.......s...t......t.....h..p...l..h......l..s.aus.....s....-tA...p....p....l....pp..p.lpp...........th.st.........pl....l..t.....h.usllusHsG.Gslulhhh..t.....................................................................................................................................	0	343	598	735
+1913	PF02646	RmuC	DUF195; 	RmuC family	Mian N, Bateman A, Moxon SJ	anon	COG1322	Family	This family contains several bacterial RmuC DNA recombination proteins. The function of the RMUC protein is unknown but it is suspected that it is either a structural protein that protects DNA against nuclease action, or is itself involved in DNA cleavage at the regions of DNA secondary structures [1]	23.50	23.50	23.50	23.80	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-11.80	0.70	-5.58	23	2678	2012-10-11 20:44:43	2003-04-07 12:59:11	11	9	2619	0	607	1935	2922	298.80	31	66.14	CHANGED	pppL-thhpslcEpLp.shppplcsoacphucchtpLpcpLt.l.thp...pplup-sssLppsLp..ssKopGsWGElpLEplLEssGL.cshpYppQssl.......tsuphRPDhhl+LPssp........hLlIDuKhsLpsYpchhsAp-sspp...ptshpphhpul+tHl+slupK.Y..........lhsscT.DaslMFlPsEuhascslcpsstlhphutcppVllsoPoTLhshLpolshha+spphpcpApcItchsucLhcchsphsschpcltppLspuspshsphhsphsptptphhpphpthpttusctptphsst	..................................................................ppLpphhpslc...Ep...L...c....sh....ccp....l....p.poap....p....pu....c....p....h.psL.......pc.pl............tt............lt....p....hp..............p.......plu....p-sssLscsLp..ssKspG.sWGEl.LpplLEsu.G.hh.cshc..Yp.pQssh..................st...........sup...hpPDhll+LP.ss+........................pllIDuKhsLsuY...p+hhs......A.....p.....-.s.t.p+....................cpshppahtul+pH....l....+sLupK.tY.t........l..s..c.o.hDaslhFlPsEshattAlcps.....s..pLh..p..uhc.pp..IhlsoPoTLhshLpolssha+ptp.p...csApcIucpsupLhcchstFs-ph.s....c.luppLspAsps...acpshsphsps..t...t...s...h..lp..phEthct.usp.......t...................................	0	190	388	502
+1915	PF02649	GCHY-1	DUF198;	Type I GTP cyclohydrolase folE2	Mian N, Bateman A	anon	COG1469	Family	This is a family of prokaryotic proteins with type I GTP cyclohydrolase activity. GTP cyclohydrolase I is the first enzyme of the de novo tetrahydrofolate biosynthetic pathway present in bacteria, fungi, and plants, and encoded in Escherichia coli by the folE gene; it is also the first enzyme of the biopterin (BH4) pathway in Homo sapiens[1]. The invariate, highly conserved glutamate residue at position 216 in Swiss:Q5F9K6 is likely to be the substrate ligand and the metal ligand is likely to be the cysteine at position 147. The enzyme is Zinc 2+ dependent [2].	25.00	25.00	25.80	25.80	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.78	0.70	-5.15	121	985	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	926	5	311	797	284	258.70	36	90.12	CHANGED	hPDVQ....sptsstplsls+VGlpslchPlplpsp.....t...pshAphshhVsL...P.sp..hKGhHMSRhhclLst.hp..p.t..lsstsl....cplLpchhpph......upsAclchpFsahlc+pu.lSs.hpuhtsYslthpuphp.ts.....t.hphplplpVshoSsCPCStplScpts...................................HsQRShsplplch....sst....l.lp-LIchlEpuhS.s.lhsllKRsDEpthsctuapNPhFVEDssRclstpLppp....sp.hssaplcscshESIHsHsAhA	.........hsDlQ....ostcs.hthsIpcVGl+slchP.lplppt...................t..posuphshsVsL...s...tcpKGhHMSRhlchl-th.p....p..th.....lshs....sl....pplLpshhpph.......pupsAplcl.shsaFhc+tu.....Plos...lpuhhsY-.Vshsuphctts..........t.hchplplplsloolCPCSKcIScauA....................................HNQRuhlolpspl........sp..p......lh...lpcll-hh...EssuSs.laslLKRsDEKhVTEcAYcNP+FVEDhlRplAtpLhpp......................stlssaslcscN.ESIHsHsAaA......................	0	100	210	268
+1916	PF02650	HTH_WhiA	DUF199; 	WhiA C-terminal HTH domain	Mian N, Morningstar A, Mistry J, Bateman A	anon	COG1481	Domain	This domain is found at the C-terminus of the sporulation regulator WhiA.  It is predicted to form a DNA-binding helix-turn-helix structure [2].  The WhiA protein also contains two N-terminal domains that are distant homologues of LAGLIDADG homing endonucleases [2].	21.10	21.10	21.20	22.80	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.53	0.72	-3.59	23	1969	2012-10-04 14:01:12	2003-04-07 12:59:11	9	6	1950	1	338	1114	114	85.00	46	27.44	CHANGED	lNRlsNh-sANlpKospAuh+plcpIphIhcplG.h-tLPppLcclApLRlpas-tSLpELGchlcs....sloKSGlNHRlRKlppIAc	.....................................sNRLsNsETANLs+TlsAAh+plp.sIphIpcplG..l-sLP...-cLp....-lApLRlp+.-hSLcELG-hlss....Pl..oKSGVNHRlRKlpclAp..............	0	134	244	300
+1918	PF02655	ATP-grasp_3	DUF201; 	ATP-grasp domain	Bashton M, Bateman A	anon	COG1821	Family	No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.91	0.71	-4.37	18	304	2012-10-10 13:17:03	2003-04-07 12:59:11	9	4	195	1	172	13200	4990	163.10	22	44.85	CHANGED	suDKhcsh+tLcst..hssP........hp.tchtt..........scphllKPtsGsGupusphscstpp....................llQ-aIEGcshSVSllussccshsLslN+QhIsh...t..............htYsGshsPh.pph..ppchhphApcllcsl....GLhGhsGVDll.......ls-..ttPYllEVNPRhTso	.............................................................................................................sKhhh.hp.hL.....pph....sl..s..h.P...................................h..............t........t...............................tt..th.llK.....P.h.......s.....G...s........G.....G.....h.......s...l...t...h....h...s...s...t.t...t......h....t...........t.............................................ll....Qca..l....c.....G.....p.....s............h....S..l....s....h....l...........s...........s...........s.......p......p.....s....h....h.....l...u....h...s..c........Q...h....l..s..h........t...........................................................ht.a....s..G......s.....h.......s......s......h......p......h......sh...........pp....p....l.....h....p.....h....s.....p....p.........l........s.......p......t.....l...........GL....t.......G....h....s...G......l...D.......h.l.......................l..s..s.........tt...a..l.l..ElN..P.Rhsu..............................................................................................................................	0	52	118	149
+1919	PF02656	DUF202		Domain of unknown function (DUF202)	Bashton M, Bateman A	anon	COG2149	Family	This family consists of hypothetical proteins some of which are putative membrane proteins.  No functional information or experimental verification of function is known.  This domain is around 100 amino acids long.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.60	0.72	-3.76	197	2355	2009-01-15 18:05:59	2003-04-07 12:59:11	10	32	1062	0	920	1576	39	77.60	28	34.40	CHANGED	+stlAsERThLAWlRTululhuhuhslhp..hh..h.t............................................hsh.........hhuhshh..............hlulhhhhhu.......hhp..ahptt...pt	....................+stLAsERT...a.L.AWlRTuLuhhuhuls.lh.phs..p..s.........................................................................................................hlth.........lhuhlhs..............lluhhhh.hau.....................hhR.aht....s..........................................................................................................................................................................	0	298	582	809
+1920	PF02659	DUF204		Domain of unknown function DUF	Bashton M, Bateman A	anon	COG1971	Family	This family consists of hypothetical transmembrane proteins non of which have any known function, the aligned region is 180 amino acids long.	21.70	21.70	21.80	21.70	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.29	0.72	-3.85	162	3883	2012-10-03 02:02:08	2003-04-07 12:59:11	10	3	1582	0	728	2452	78	66.50	31	65.64	CHANGED	hS..hDAhAVuluhuhh.............php....hhhsulhhGlhpslhshlGhhlGphhu..p..hlsph..........uchlGullLlhlG	..................hShDAhAVuluh.uhh.............psp......hlhsulhhGhhphlhsh.lGh.hlG.ph.h.u..p...hl.s.ph...............sc.hluullLlhlG......................	0	276	519	622
+1921	PF02660	G3P_acyltransf	DUF205;	Glycerol-3-phosphate acyltransferase	Bashton M, Bateman A, Eberhardt R	anon	COG0344	Family	This family of enzymes catalyses the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate to form lysophosphatidic acid [1]].	21.00	21.00	25.80	25.70	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.15	0.71	-4.71	127	3881	2009-09-13 07:44:17	2003-04-07 12:59:11	10	9	3433	0	833	2498	1770	180.00	37	84.40	CHANGED	lluY.LlGSlshuhllu+hhthhDlRphG.SGNsGATNshRsh.......GtphuhlshlhDhhKGhlsl.hl....uphhhhs.hhh.....hh...................suluull.GHhaPlahpF+.....GGKGVATshGl..llslsshhsl.....lshh.lahllhhlo+.hs..........SLuSlh...uslshslhshh..........................................thsh.hhlhsh...hluh..lllh+H+pNIpRLl	...................................lluY.LlGS.Issulllu+l.h..t.h..h..DlRphG.S...........GNsGATNshRlh.......GK.t.uuh.hsllhDhhKGhlsl.hl..........s.hh.hs.h..sshhh..............hh.......................................suluA.lL.GHhaPl..Fht.FK................GGKGVATuhGs.......lls.l......s............hh....s.l...........h.hhs....sall.slhls+.hs...............SLuull.......uul.hsslhshh..............................................h.p..h...h..hh.hsh.....hluh..lllhRH+sNIpRl.....................................................................................................................................................................................	0	284	542	701
+1922	PF02675	AdoMet_dc	DUF206; AdoMetDC; 	S-adenosylmethionine decarboxylase 	Mian N, Bateman A, Moxon SJ	anon	COG1586	Family	This family contains several S-adenosylmethionine decarboxylase proteins from bacterial and archaebacterial species. S-adenosylmethionine decarboxylase (AdoMetDC), a key enzyme in the biosynthesis of spermidine and spermine, is first synthesised as a proenzyme, which is cleaved post translationally to form alpha and beta subunits. The alpha subunit contains a covalently bound pyruvoyl group derived from serine that is essential for activity [1,2].	25.00	25.00	27.60	27.30	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.43	0.72	-4.15	134	1798	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	1523	19	460	1159	1636	119.90	39	60.28	CHANGED	Hllh-hass..s.chLsDtchlcphltcAsctuGATllsh.thacF...pP..........pGVoulslluE....................................SHlolHTWPEhs........aAslDVaTCGp..ssPhcA...hphlhcshpscphphpp.hpRG	......................................................................-pLhssppLpclLs-s.sphhGA.s.l..Lsl..uppca.....pP..........QGsS.s.slLlSE................................................SHIslHTaPEpp..........hAsIDV.TCGs...lsPhcA.....lsYLhcpL.cuc.hsshch.hsRG........................	0	183	309	389
+1923	PF02676	TYW3	DUF207; 	Methyltransferase TYW3	Mian N, Bateman A, Wood V, Mistry J	anon	COG1590	Family	The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis [1].  yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA.  TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner [1].	20.50	20.50	21.00	20.70	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.47	0.71	-5.20	42	374	2009-01-15 18:05:59	2003-04-07 12:59:11	9	24	292	11	258	380	11	199.60	29	62.09	CHANGED	cppKpphLpclt..........-tp.cGplDcsIhsllchIN...uhpshhTTSSCSGRIoVh.p....................tp.hp+.......................tsupWLahsHcs...................hphpplhcslptshsst.....................lhh+hcP.ILHVhs+sLcpAptlhshAhssGF+cSGItshp...................pphlVtlRss.h+l-sPluhps...............chlV.sc-YLphLlcluNc+hpcspc+lpRLppslcp..hhp	.................................tKtphLppl...........DhS.+GplDtslhsllphlN...sh.tshhTTSS....C.uGRlslhtps.............................t...tc.............................................................................tsupWLhhsH.c.............................................................hp.pphhphhph..ttttt..........................................................lhh+hEPh........ILHVhspshppAphLhps.A.h.s.uGF+p....SGltshp................................................tphhVulRss...htL-sPluhps.........................phhV..sc-Ylph....Llp....l...uNp+hpcNpc+hp+hhptlpt...t........................................................	1	79	129	198
+1924	PF02677	DUF208		Uncharacterized BCR, COG1636	Mian N, Bateman A	anon	COG1636	Family	\N	21.10	21.10	21.10	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.35	0.71	-4.49	75	1642	2009-09-12 22:47:58	2003-04-07 12:59:11	9	4	1534	0	279	1063	255	165.00	42	73.24	CHANGED	lLLHsCCAPCSsaslctLppp..shclosaFYNPNIHPhpEYhhRhp-sc+hspch......slphltu-..Y-...hcpahctsc..GhEp-sEtGt.RCthCachRL-poAphApEtGFchFoooLhhS.aKshpplpchGcchupca.slpahhpDaRKtsGhpcslc.......luKchslYRQpYCGClaShc-p	..............................lLlHsCCAPCSs.shEhLpp....h-hslaFaNPNIHPhpEYhhRtpppt+Fscch...................sl..t..hl-.u-..Y-....c.pahcts+.....Gh.E..pEsE.t....G.hRCphCF-hRh-psAphAh.......E.......tG.......achFoosLslS.hKshp.pINphGhcssph........Y......s..............lpYhs.sa+KssGhpRtlE.......hs+c.phY+QpYCGClauhpp.p............................	0	102	190	241
+1925	PF02678	Pirin	DUF209;	Pirin	Mian N, Bateman A, Moxon SJ, Yeats C	anon	COG1741	Family	This family consists of Pirin proteins from both eukaryotes and prokaryotes. The function of Pirin is unknown but the gene coding for this protein is known to be expressed in all tissues in the human body although it is expressed most strongly in the liver and heart. Pirin is known to be a nuclear protein, exclusively localised within the nucleoplasma and predominantly concentrated within dot-like subnuclear structures [1]. A tomato homologue of human Pirin has been found to be induced during programmed cell death [2]. Human Pirin interacts with Bcl-3 and NFI [3] and hence is probably involved in the regulation of DNA transcription and replication. It appears to be an Fe(II)-containing member of the Cupin superfamily.	26.10	26.10	26.50	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.44	0.72	-4.17	52	4965	2012-10-10 13:59:34	2003-04-07 12:59:11	11	18	2388	5	1562	3896	1851	109.40	35	40.71	CHANGED	shclpcshst.........shhphhsPFlhhDphsPspht.u............shuh.ssHPHpGhETVTYlh...cG.clpHcDShGscuhlpPG-VphMTAGpGIhHSEhs.st...........stsh+GhQlWl	.............................................................s....tp.hut.....shhps.hpsF.Fh..-a.a..sPp..ths.us............................-.h....stGF.ssHPH+shEh.l..Tall........c...G.pl.p...Hc..DS.h...Gs.......p.s..............h.............l...p.sG.-......lQhMoAG....s....GIh....H.SEhsssp........................spslchhQlWl...........................................	0	450	941	1293
+1926	PF01595	DUF21		Domain of unknown function DUF21	Bashton M, Bateman A	anon	Pfam-B_618 (release 4.1)	Family	This transmembrane region has no known function.  Many of the sequences in this family are annotated as hemolysins, however this is due to a similarity to Swiss:Q54318 that does not contain this domain. This domain is found in the N-terminus of the proteins adjacent to two intracellular CBS domains Pfam:PF00571.	25.10	25.10	25.20	25.10	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.93	0.71	-4.99	126	9166	2009-01-15 18:05:59	2003-04-07 12:59:11	15	26	4552	0	2462	6747	2342	186.30	24	42.42	CHANGED	hhllhlhlL.lhluuhFuusEhAlhulspsclcpht....cp..ss.....ptApt.lhplhpp......sphLsslll...Gsslsslhhu.slushh...hhphhs...................huh.hluhllhThlhl..lhGEllPKsluh.p..tsppluhhhuhhlthhhhlhh.Plshllshhs.phlhphhshp.........t.hhop.cElctllp.up.ppG....slc..pcE	..................................h..llllhlLlhlsu.aFu.uuEhAlhulp+s+lc.p.hs.........cp.....Gs.....................ppApt....lh...cl...h...p.p..........sphLosl..l................Gh.slsslhhu..hlupsh.......htp..hhts..................................huh.hluh.sl.lThlh.l........lhuE......lh..PK.slAh..p..ts-pluh...hhuh..slthh.h...hl..ht..P..l...lal.ls.ths.sh.l....h+.h.hshp..............ptth..oc...-E....l.c.tllptut.ptG.lpt..........................................	0	785	1593	2105
+1927	PF02679	ComA	DUF210;	(2R)-phospho-3-sulfolactate synthase (ComA)	Mian N, Bateman A	anon	COG1809	Family	In methanobacteria (2R)-phospho-3-sulfolactate synthase (ComA) catalyses the first step of the biosynthesis of coenzyme M from phosphoenolpyruvate (P-enolpyruvate). This novel enzyme catalyses the stereospecific Michael addition of sulfite to P-enolpyruvate, forming L-2-phospho-3-sulfolactate (PSL). It is suggested that the ComA-catalysed reaction is analogous to those reactions catalysed by beta-elimination enzymes that proceed through an enolate intermediate [1].	25.00	25.00	30.60	39.00	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.55	0.70	-5.36	30	234	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	207	2	133	248	145	238.90	32	79.40	CHANGED	hthspRsp..K.PRppGlThllDKG...luhpthcDhLcsuupYIDhlKhGaGTuslhspchl+-Klclh+caslhsasGGTLhElhhh..psph.-cYlcps+clGFsslElSsGolclsp-c+tch....IcpspctGhpVhoEVG.....................pKcsppptp.psschlchhpp-L-AGAphVIlEuRESGps.Glacss...Gpl+sshlpcllpp.ls..hc+llFEAPpK.....ppQthhIpchGssVNLuNIs.p-llsLEsLRtGLRGD	.............t..stRstK.PRppGlT.lhD.u.........................huhphhcDl.lc........s......sGpalDhlKhuhGotslhspp.l+-tlclh+paslhlhsGGhhhElhht....ps.p...h...ccYlcts+clGFcslElSsGsl.slsp-cphch....Icphp.ptGhp.shsElG......................pKs.ptths.pstchlchhcppL.-.A.GAphlhlEuc......Glhcss...uphRp-llppll.pp.ls...hc+lhFEAspp........ptptaaIccaGssVNLsNls.scllsLEsLRhGLhus......................	0	56	91	118
+1928	PF02680	DUF211		Uncharacterized ArCR, COG1888	Mian N, Bateman A	anon	COG1888	Family	\N	20.90	20.90	20.90	50.20	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.03	0.72	-4.18	22	122	2009-09-13 14:06:05	2003-04-07 12:59:11	9	1	121	29	80	118	3	93.30	43	97.60	CHANGED	M...s..lRRlVLDVLKP.+pPsll-lAtpLuclcGV-GVNIoVhElDpcTpslplTIEGsslDa-pIcchIEphGusIHSIDEVsuGcpllEp.cssQ-	........slRRlVLDVLKP.+pPsll-lAppLuclcGV-GVNIoVhElDh-TpslplsIEGssl-a-clpcsIEchGusIHSIDEVsuGc+llEt..................	1	19	41	62
+1929	PF02681	DUF212		Divergent PAP2 family	Mian N, Bateman A, Yeats C	anon	COG1963	Family	This family is related to the Pfam:PF01569 family (personal obs: C Yeats).	21.70	21.70	21.80	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.64	0.71	-4.46	40	730	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	571	0	233	576	175	132.70	41	83.60	CHANGED	lhsNtsLhsAllAhhlAQhlKlhlphhhp...++hch.......phlhsTGGMPSSHSAhVoALuTulGlppGasSshFAlAslFAlIVMYDAuGVRRuAGhQAclLNp.Llp-h.p.............t..tpcpLKELLGHTPlEVhsGulLGlhlu	...........................hpN.sLhuulluhhhAQhlKhhhp.h....htp.....p.+.h.ch.......phhhuoGGMPSSHSAsVoALuoulGl....ppGhsSshFAlAslFAhIVMYDAsGVRptuGcQAplLNp..l...h..pph.pth............................tpcpL+El.lGHoPhpVhsGullGlll...........................................	0	86	168	208
+1932	PF02697	DUF217		Uncharacterized ACR, COG1753	Mian N, Bateman A, Eberhardt R	anon	COG1753	Family	Structural modelling suggests this domain may bind nucleic acids [1].	25.10	25.10	25.20	25.10	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.55	0.72	-3.73	16	123	2009-09-10 16:57:48	2003-04-07 12:59:11	9	1	63	0	61	129	9	67.10	27	87.20	CHANGED	sKTIoIsD-VYccLlchK..tscSFS-VIpcLlc.......spcctLhchaGhls---h.cEhc+clpEs.tphcc+h	..........KTIslo--sYccLpchK.pssESFS-lltRLlp.......tpt...cplhch...h..Gh....h...s-c..-h...cchtcphcc............................................	0	9	40	54
+1933	PF02698	DUF218		DUF218 domain	Mian N, Bateman A	anon	COG1434	Family	This large family of proteins contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The family includes   SanA Swiss:P33017 that is involved in Vancomycin resistance [1]. This protein may be involved in murein synthesis [2].	24.30	24.30	24.30	24.30	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.02	0.71	-4.73	148	7246	2009-01-15 18:05:59	2003-04-07 12:59:11	12	18	3217	2	1345	4642	908	154.40	20	61.35	CHANGED	pscs.llVLG.........th..stt..sh..stp.Rl.ptulcLhc....t.shssh......lllS.....Gu.s.t......................hsEAphh......pchhhpt.G..ls.....tpplhh....-sp.ups...ThcNA..thst.plhp.ppsh.........t...ph.l.lVTsshHhhR.......Ah...hhhcptuh.pshshsssh.ssht................................................phhh+E.hhu....h	....................................................................................ph.llVLG...............th...s.t......s.h........htt.Rl.stA.....h....plac.............p..s..s....sh...............lllS.....GGputs...........................shsEA...psh.............tchh.hp..t..G.......ls......................tp.p.Ilh.....-.sp.ut.s....Th-Nhhhuc..plhp...pp...................................ph..l..lVTssaHh.R........Ah..........hhh....p......p..h..Gl..p...s.......s..hs..s.s..........................................................h..................................................................	0	387	838	1133
+1934	PF01629	DUF22		Domain of unknown function DUF22	Bateman A	anon	Pfam-B_1137 (release 4.1)	Family	This domain is found in 1 to 3 copies in archaebacterial proteins.  The function of the domain is unknown. This family appears to be expanded in Archaeoglobus fulgidus.	25.00	25.00	73.10	70.50	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.04	0.71	-4.58	23	49	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	29	\N	41	51	0	107.70	28	79.39	CHANGED	hp.c....hphshchsGclh+cc..lchcsauYp.pup.lupWEslIAsEcl-VccGEshhl+I+clclPssTllhPhslhRHAhGsllDVspps.PtpVE-c+plscAlFlsscDG	................ht.............htscltchc..lctp.hsap..htp..huphcsllAsEcl-l+pG-hc.I+I+cIplPspollhPsshhpHslGpllslscct.Ph.lEp-RplcpAhFlsstDG..	0	20	30	37
+1935	PF02713	DUF220		Domain of unknown function DUF220	Basthon M, Bateman A	anon	Pfam-B_1412 (release 5.5)	Family	This is family consists of a region in several Arabidopsis thaliana hypothetical proteins none of which have any known function. The aligned  region contains two cysteine residues.	29.40	29.40	30.70	44.10	28.10	27.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.70	0.72	-4.30	17	83	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	13	0	48	82	0	69.60	52	24.65	CHANGED	hSGslPIpLllcEN+Ksho..uKYKKcKMMFMKlFEGsWKVEPLYVDs-RLCKppcPKShEEY++CSGGpG+IuSK	........................SGslPlplll-EN+Ksho............sKYKp.pKhhFMKsFEGsWKVEPLYVDpERLC+.....shcPKShEEY+pCSGGpG+IuSK.............	0	21	27	30
+1936	PF02714	DUF221		Domain of unknown function DUF221	Bashton M, Bateman A	anon	Pfam-B_1596 (release 5.5)	Family	This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.	28.70	28.70	28.70	29.20	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.88	0.70	-5.57	82	1418	2012-10-02 00:51:22	2003-04-07 12:59:11	10	55	296	0	1031	1387	24	296.20	22	36.12	CHANGED	uFlpFcophsAphssQ....................shtppps...hph..hsthuspPcDllWpNl.slshhp+hh+phhsshhlhhlllhaslPVuhl.uhlsslstLsphhPhLphl...t...hs.hhh.ullsGlLPslhLslhhhllPhlhchhuphpGhhopuphEhpshsp......hFhFhllplFLlsol.uuoshsh...lpplls.............pssslsphLApsL..P......ptusFalsYlllpulshsuhpLLplssLlhhhlhtthhs......pTPRchhpth.s.sshsaGshaPhhhhlhsIslsYo...lluP..lILsFuhlhFhlsahsa+YplhYlas.pph.-ot...Gtha..PhshtplhhGlhlhplhhhGlh	...............................................................uFVpFpsthtAthshp..........................................shtp..p.s......hph....hthAspPpDlhW......pNl....tls.hh..p...h.hh...R....phh..h.......h..h.l.hh.l.h.....h...h....a..s.....hPs.sh.l..ss......l.....s........p........l......s......hl...........pp..h......h......s...h....lp.l...........................hhh...s...h...lpuhLPsl.h.L.hl.h...h..l.l.P......hl..h.hh....hu.t.h.p.G.h.h..otothchtshpp......hah..Fh......l..h.p....lhll.s.sl.sussh.sh.......htthhp.........................................ts.p.p.h......p.hl.u.t.sl....P.........ptusF.a.ls.....Yl..lhpuhhs..h.uh..p.Ll.....pl..s.s....Llhhh...h.....h..t..h..hht...........posc.....c.....h..h.......th.......h.............p.....t....hp....au......t......hhs.h....hhhh...........h.............h.....l................s.....l..sYu...hlsP..lll..sF....shlhhhltahsh+aplha..........sh...tph..-st..........G.t.ha.....shhh..t..ph..hhulhlhplhhhGh..............................................................................................................................	0	345	611	869
+1937	PF02720	DUF222		Domain of unknown function (DUF222)	Mian N, Bateman A	anon	Pfam-B_1711 (release 5.5)	Family	This family is often found associated to the N-terminus of the HNH endonuclease domain Pfam:PF01844. The function of this domain is uncertain. This family has been called the 13E12 repeat family [1].	24.40	24.40	24.60	24.40	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.74	0.70	-5.29	29	2037	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	207	0	557	1830	116	259.90	21	64.47	CHANGED	thutlt-hpsttcpLsuhtthlhscl.....spcsh.tttGsculushlAsphplStupAspplphAtpLtpR...........LPtsAsAhtpGclshcpVpsItttscplscshslssh-tApsshlppusp..hpscpLtthscphhthh...-...............................PDush.....sct-ttc.......cRtlslus..ts-GMoplpGhLsscsuAsh-shLsphAus.hCss..................DsRossQRptDAlsAll....RhshssGphsp.sGh..........sslllpsshpchpssust............slsGhGslLPhp-lhcLApcAp..Lt.lh.t.hupPls.hs+spRhsSss.RhhLhsRD	............................................................................................................................h...........h.tth.sh...........h.....h.ph.....................ttts.......t....s.h......p.......h..s.t..l.u..t..h.t.h.o...........s.tAt..p...hh.....t......A.........t...s..L.h......................................................hst.stts.......htt...Gtl......s.t.phthlhth.......h.......t...........l...............t............s..............h...........t.....h..........h.......p..t....t...........s....t..........h.....t.t.h..t.......hps..tp...l.....t.thh.p.thhthh.....c...............................................................................................................s..c..u...............pttc.ttp................pRtl.ph.....t..t...t.....-.Gh.stlp........u.h.Ls.st...tt.sthp..shl..sthu......ts...hsss......................................................................................................D.sR.o.s.Q.p.....p.t.D.uhhthh...................................phhht...s.s...t....s....p...t.uh...........................................st.lh..l..p..h.s.....h.p.p..hthtss.................................................hhhs...hs...lsht..h.h.p....h........s.t....p........ut..........ht..............................s......s.....h......h.......c.....thh.s.t.t.hl.hpD............................................................................................................	1	124	377	513
+1938	PF02721	DUF223		Domain of unknown function DUF223	Mian N, Bateman A	anon	Pfam-B_1714 (release 5.5)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-10.03	0.72	-3.90	15	441	2012-10-03 20:18:02	2003-04-07 12:59:11	9	27	17	0	209	461	0	88.80	23	26.26	CHANGED	sLlLsDcpG......splcATIsp+hushYt.........-plp..EspWcsIooFsVp.sssulR...sTsHca+IhFhcp..........ThVspusshpssh.ahshTPFDhIl--osspslL	.......................hlLhDcpG.......spIpAsl.p.p.phh.sp.ap.........shlp..EsphhplpsF.p.Vstss.sth..R...sosHca+ltFhts..........Th.lpt...s...psh.s..s........hh..p..hs.Fs.lhtt.....................................	0	3	13	25
+1940	PF02890	DUF226		Borrelia family of unknown function DUF226	Bateman A	anon	Pfam-B_1255 (release 6.0)	Family	This family of proteins are found in Borrelia.  The proteins are about 190 amino acids long and have no known function.	25.00	25.00	25.20	25.20	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.84	0.71	-4.41	21	456	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	31	0	21	314	0	133.60	48	76.35	CHANGED	lapFt.spsKcp+hhlhF+plaNpp+.hpthpLFPl+E..sDKFLGIaYGY+K.h.Kshhl+Yp...stspKsY.shsKsYYIEFRFKKGSVFCYl+ultpLL+.K-KhsTpY.ptLlcplhcLE+cVYcFYsKKLss..tGlIhKWIpK.NQ	............................hhpFt.sppKcpcFhlohRsLF.N...tc+.hpthpLas.l.KE..sDK.FlGIaYGa+K.h.Ks..h...hlKYp...sssp..KsY.sls.KsYYhEFRFKpGSVFCYl+uLhpLL+.Kc+tsscY.psLhshhpcLEppVYcFYsKKhsc..tG..hlhKWIhK.N.............................	0	20	20	20
+1941	PF02989	DUF228		Lyme disease proteins of unknown function	Griffiths-Jones SR	anon	Pfam-B_1298 (release 6.4)	Family	\N	25.00	25.00	41.60	41.40	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.23	0.71	-4.72	7	322	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	26	0	26	250	0	188.30	51	91.81	CHANGED	Mu-hsplccpa...cKhtclpthh...Kssppssu.ltNSl......cF+DcNl.a.spGGspoSptDKlENa...PhpuasYKRGVKLs...spsspl....plEsGGGsDLYGlClDlDEFS+TATVlPITNNFEGYLlsK...ssolKscDKL.hNpcG.LEKssGu....tssINAlALScAhpls...................pDlall+VtlFGN+ulpc	.............................................u-psplccpa...cKlsElcslh...Kssppssu.llpNSl......cF+DKNlhasspuGspoSptDKIENY...PspuaPYKRGVKLl.....sppspl.......pVEs..GGssDLYGIClDlDEFSpTATVlPITN.NFEGYLlsK...ssolKsGDKLshNppGsLEKssGu....tssINAhALScuh.pls....................p-l.ll+VulFGN+ulc.................	0	17	17	17
+1942	PF03003	DUF230		Poxvirus proteins of unknown function	Griffiths-Jones SR	anon	Pfam-B_1300 (release 6.4)	Family	\N	20.40	20.40	22.30	21.10	18.90	17.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.29	0.71	-4.60	41	207	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	61	0	0	168	0	126.70	31	43.33	CHANGED	IhsaCpppps...sppChClaPs...pshlphucchhtP+hCWhc.C...p+sspaLlpspcpphupCplssCsIslssLpl..supsclpssCt....sstshhsshspschlppphphsh......lhs.hhhhl....slhllhhl	...lhsaCsppps...sppCtCshPs...pshlppu.+hh..t..P+hCWhccCs..s+sspaLhtspcpshupCplssCs.....IslssLslt.supsclpssCs....psptsssss.p.tsc.h.lppphp.hsh......hhh..hlhhl....slhllahh................................................	1	0	0	0
+1943	PF03008	DUF234		Archaea bacterial proteins of unknown function	Griffiths-Jones SR	anon	Pfam-B_1430 (release 6.4)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.59	0.72	-3.88	91	702	2012-10-11 20:44:43	2003-04-07 12:59:11	9	11	463	0	243	706	46	99.90	25	24.52	CHANGED	WFRFlhPshsh.lEhGphc.hh.cplp..pph.spYhGhhFEcls+..-hLh.ch.t.t.h.....hsclG.+WW........c.....+sp..EIDllAlscppt....hlhsEsKWps.............ttcs+pl	..............................WFpFlhPst..sh.l-hsp.hc.lh...phl..c....pph.sp.a.huhsFEpls+..-hlh.ch.t..........hsp.lG.pW..W.......................c..........+pt....EIDlluh..scp...p..........hlhuEsKaps............p..................................................	0	80	141	188
+1944	PF03057	DUF236		Protein of unknown function	Griffiths-Jones SR	anon	Pfam-B_488 (release 6.4)	Family	This family represents the C-terminal region of a number of C. elegans proteins of unknown function.	21.20	21.20	21.50	21.80	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.83	0.71	-4.22	8	173	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	9	0	167	116	0	106.80	37	73.74	CHANGED	K...............................................suhAuTHDPNYQTLAGLssNVFpcKsG....ssuAGGuuPsAPA.tsuKPGMAATHDPNYQTLAGLsN.slFc..KKD.Gut.......sAuGsuuPtsP.s-psuKAAT+DPNYQTLAGlsNDlF.............................................................s	.......................................................................................................t....s.t.DPNYQThsulss.s....hh..ttt.........ss....ss........s...s......Pt..s...ss...............ss.t.......hAuTpDP.....NYQTLAGlss..s....lFt.....cK.s..ttt.......................ssuu.ss.sPtsP..ststhAuTpDP.NYQTLAulss.shF..............................................................t................................	0	64	91	167
+1945	PF03072	DUF237		MG032/MG096/MG288 family 1	Mifsud W	anon	Pfam-B_2298 (release 6.4)	Family	This family consists entirely of mycoplasmal proteins. Their function is unknown. Another related family, Pfam:PF03086, also consists entirely of mycoplasmal proteins of the MG032/MG096/MG288 family. Some proteins, such as Swiss:P75072, are included in both families, but of course differ in the aligned residues.	25.00	25.00	149.50	147.70	21.90	18.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.75	0.71	-4.27	14	35	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	4	0	14	29	0	135.50	36	26.32	CHANGED	LRtpLsphushpLs.lp..plplpsp.sss..........slpWNcphsshchppspPYcFpFElshcYpGsYslphathhhs...huuIPupWpGchplpahlDGclspahss+.DYPuohFpFs-..scLLFs.HlhQcIpVps	LRtpLsppuslpLs.lp..plplpsp.sss....h.....sIpWNcchsshchppspPYpFpFElshcYpGsYslphathhhs...hGuIPupW+GchplpahlDGclssWhssK.DYPGohFpFs-..scLLFs.HlhQ+Isspt..	0	11	11	11
+1947	PF01638	HxlR	DUF24;	HxlR-like helix-turn-helix	Bateman A	anon	Pfam-B_1509 (release 4.1)	Family	HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.94	0.72	-4.35	14	8192	2012-10-04 14:01:12	2003-04-07 12:59:11	12	15	2896	25	2341	7312	707	89.20	34	69.10	CHANGED	llGuKWphLILhpLhp.Gs+RFsElc+tlPsIop+hLoppLRELEp-GllpRpVYsplPP+VEYSLT-hGcsLpPlltthpcWGppahpt..	......................................lus+W.p.h.l...Il.h..p..L..............h........p.....G............s........p...R.......F.....s..-..L.p.+.p.l.......s......u.......l.....o.............p+.hLop.....p.....L+cLEpcG..l.l..p..R....p..s....a...s..p....s..P....P..+..V....E..Y.s.L.T.c.h.G.c.s...L.t.s....l.....l.p....slt.p.Wucpah...hh.................................	0	770	1605	2009
+1948	PF03086	DUF240		MG032/MG096/MG288 family 2	Mifsud W	anon	Pfam-B_2385 (release 6.4)	Family	This family consists entirely of mycoplasmal proteins. Their function is unknown. Another related family, Pfam:PF03072, also consists entirely of mycoplasmal proteins of the MG032/MG096/MG288 family. Some proteins, such as Swiss:P75072, are included in both families, but of course differ in the aligned residues.	25.00	25.00	135.40	135.40	22.70	22.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.59	0.71	-4.47	13	35	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	4	0	14	32	0	120.10	40	22.97	CHANGED	hsFpssYhsssssl.sLsFsLphpTsNFusLp-Lp-oFsp.sGssLssQLFaKssVsKLsh.ssNDLTplApTslu-shhshplsLscSIl....phsLppscpcF-ccllpPFhpcRpcAKtta-	.hsFcssYhsssspl.sLsFuLphpTsNFosLp-Lp-SFsp.sGssLssQLFaKssVsKLsh.ssNDLTplApTAlG-slhshplsLscSIl..cssLpp.scppF-pchlsPFhpcRpcAKtta-.	0	11	11	11
+1949	PF03112	DUF244		Uncharacterized protein family (ORF7) DUF	Mifsud W	anon	Pfam-B_2667 (release 6.5)	Family	Several members of this family are Borrelia burgdorferi plasmid proteins of uncharacterized function.	20.70	20.70	21.30	20.70	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.91	0.71	-4.69	7	158	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	30	0	10	164	1	148.00	70	39.00	CHANGED	hEl.plpppIhps.thphh...NhD.pshhphlc-hV.pSDFYpsGlEFDWhsEFVEYV-ClDLEI+s-psAhNLEpsLhEIpsLpsELNKIQ....NEN+K+....EKPIKDlLKh+IscIhpcasLIsplNY+FccFVFshDPpKRAIoDRFKuLhPhSu+l.a.ss	......................hElhNL+KDIaSNYR--YLMAHNFNpDTFIKLV...E...DLVE..RSDFYSSGVEFDWAREFlEYVDCsDLEIKDsQSAENLAhDLMEIDSLpKELN+IQ....NENKKR......EKPIKDhLKMhIaNITNpYPLIE..plNYKFtEFVFTLDPKKRAISDRLKGLLPTSGsVFFPSN......	0	8	8	8
+1950	PF03136	Pup_ligase	DUF245; Proteosome_20S;	Pup-ligase protein	Mifsud W, Bateman A	anon	Pfam-B_3042 (release 6.5)	Family	Pupylation is a novel protein modification system found in some bacteria [1]. This family of proteins are the enzyme that can conjugate proteins of the Pup family to lysine residues in target proteins marking them for degradation. The archetypal protein in this family is PafA (proteasome accessory factor) from Mycobacterium tuberculosis [2]. It has been suggested that these proteins are related to gamma-glutamyl-cysteine synthetases [1].	25.00	25.00	45.70	34.20	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.53	0.70	-5.88	31	731	2012-10-02 17:21:26	2003-04-07 12:59:11	10	3	352	0	214	642	154	443.10	44	90.47	CHANGED	+RlhGhETEYGIsssspsssssl..o.p.l.......................hh..at.EsPhcDARs..hclpth.stssup...s................................NlhLsNGuRlYlD....tuH..........PEYSoPEsssst-hVhaD+AG-clhppAspcApph.ut...........sslhLaKNNsDucG.sSYGsHENY.....................................................................................................................LhsRsssF.splsctLhPFhVoRQllsGAGRVG........hs.suppsu...FQlSQRADalcptVuhpT.ThsRPIINTRD..............EPHADs-+YRRLHVIlGDuNMSEhoshLKlGoTuLVLphIE....sGh.....hs-Lsl..........csPVpul+plSHDh.oLptplpLtsG+phTAL-lQppYh-pstpalppc.s..........sspspcVLshWpcsLstlcsssh...........psusclDWlsKhpLl-pa+pR........puLshsc...P+LthlDLpYpDlcsp+GLaptLhp+GphcRLls-pclppAsspPPpsTRAhhRGchlcphs...pcl.......hsAsWsplhl	............................................pRIhGlETEYGloss.......s...stpsl..............................................................sP..csARt..hhhphs..uts.us....................................................................NlhLsNGARLYlD....tuH..........PEYuoPEssssh-hVhaD+AGEplhcshstcAp.pp...hut...........sslhLaKNNsDu.................t.G.sSYGsHENY.....................................................................................................................Lhs.Rps..........s....F.splscsLlPFLVTRQllsGAG+Vs...................................ps...u...c..tss..........FplSQRADal.ptVu.tT.ThsRPIINTRD..............EPHADu-+YRRLHVIlGDuNhuEsoThLKlGoTsLVLchIE...........sGss............hpDlsL...........ssPlpAl+plS+Dh.o...h.ct.l.pL....s...........s....G........R.p.....h..o..ALplQccYhp+s.tcalpp+t..........................sspsppVl.chWs.csL-sl-.sssh.............phusclDWshKhcLlctappR................pshshss......P+lttl..D...LpYpDl+.s.+G..Las.....tL.t+Gt..hcRl.ss..-ppl.tcAsspPPpsTRAhhRGchlppht....scs.......hsssWsplhh....................................	0	66	156	198
+1952	PF03158	DUF249		Multigene family 530 protein	Mifsud W	anon	Pfam-B_2304 (release 6.5)	Family	Members of this family are multigene family 530 proteins from African swine fever viruses. These proteins may be involved in promoting survival of infected macrophages [1].	23.10	23.10	23.20	24.90	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.42	0.71	-4.77	9	88	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	11	0	3	75	0	189.60	43	38.18	CHANGED	GALEucpYDL...IpKYasQIpDhHcILPLIQDPchFE.....KCH-Lsp.Csh.CLlpHAlKasMLsILQKa+cpLstc...hhsQhLFEhACcpp+a-llpWI..utsLplYp.pslFsIAhs++DloLaoLGYpLlhs+h.sp......p.shs.LLo.pHLcpAutKGLLcFhLETLKYGGsls...hlLopAlpYsHRKILsYFl+p	.....................GALcucpYDL...IpKYasQItDhHpILPLIQDPchFE.....KCH-Lsh.CshpCLlpHAlKaNMLsILpKa+-pLp.tp...hhsQhLFElACcpp+h-llpWI..upsLtlhc.cslFsIAhsp+DloL..aoLGYpllhsph.sp......p.shhsLLs.pHLchAutKGLL.FhLETLKaGGslc...hlLotAlpYNHRKILsaFl+p..............................................	0	3	3	3
+1953	PF03151	TPT	DUF250; 	Triose-phosphate Transporter family	Mifsud W, Bateman A	anon	Pfam-B_3234 (release 6.5)	Family	This family includes transporters with a specificity for triose phosphate [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.80	0.71	-4.57	62	2906	2012-10-02 19:55:49	2003-04-07 12:59:11	11	51	371	0	1969	5343	564	144.50	19	38.47	CHANGED	Ghlhshh.ushshulp.shsphlhpc.............................................tthsshphhhhhu.hushhhlss.hhhh-thp..h.........................h.hhhhhllhsulhhahhshusahlltpsSslohsVsushKpsllllhullhFp...sp.lohhshlGhslulhGhhhYsh	..............................................................................................................................................................................................................................Ghhhshh.us.hhtuhp.lhs.p.hhh.p.p..........................................................................................................................................hp.h.ssh.s.h..h..h...h....h.u....s.h...s.....h.h.....h.h.........h.sh.....h.....h..h......h...-..t..h..t....hhh.th...........................................................................th..hhhl..h.hs.u.l.h.u..a......h.h.s.h....s.s.a..h....h....l..t...t.s.....S...s.l...Th.s.l...sGsh...Kp..hh............s.lh...hu.hlhat...............s...ho..h.h....s....h..lGhsl.s.lhG.hhhYs.............................................	0	634	1165	1620
+1954	PF03159	XRN_N	DUF251; 	XRN 5'-3' exonuclease N-terminus	Mifsud W, Moxon SJ	anon	Pfam-B_2349 (release 6.5)	Family	This family aligns residues towards the N-terminus of several proteins with multiple functions. The members of this family all appear to possess 5'-3' exonuclease activity EC:3.1.11.-. Thus, the aligned region may be necessary for 5' to 3' exonuclease function. The family also contains several Xrn1 and Xrn2 proteins. The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalysing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus [3].	22.90	22.90	24.00	23.10	22.80	21.50	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.75	0.70	-4.98	17	896	2012-10-03 20:43:45	2003-04-07 12:59:11	13	24	311	10	593	928	242	207.90	41	22.33	CHANGED	MGVPtFFRWLSc+YPpllpslhEcp.......................EFDNLYLDMNGIlHsCoHPpDc..shshsE-E.....hahtlFcYlD+lashlRPRKLLahAlDGVAPRAKMNQQRuRRFRuA+-Apctptctpchtcph.pp.........................................cpFDSNsITPGT.FMspLupsL+YaIpp............................KlssDstWp.slclIlSsssVPGEGEHKIM-aIRpp+u.pPsaDPNT+HClYGLDADLIMLGLuTHEs....HFslLRE-l	.......................................................................MGlPthaRWlsp...+YPt..h.........h.....c...pp...............................................................................................-hDN...LYLDMNGIlHs.C......s.Hspsp...............h..h.s--c......................h..h.ht.lFp..Yl-cl.h.p.h.l.+.P+....+l..ha...........hA...........l.................D..GV...............APR.A.KMNQ.QR.uRR..F.R.uup-s.t..pt......t.pt...p..t..p....h....t........................................................................................................................................ptaDSNs....ITP............GT.FMs..pLsptLca.a.lt...............................+.l....s.p......D..s.t......W.p....tl.p.ll.lSstps.........PGEGEHKI...Mc......aI......R....p....p+s......p...........ss.........a....s................P.Ns...cH..........slaGh............D...ADL.....IMLuL.s.....o.....H.-s.....pFplLREp................................................................	0	247	365	514
+1955	PF03162	Y_phosphatase2	DUF252; 	Tyrosine phosphatase family	Mifsud W, Yeats C	anon	Pfam-B_3756 (release 6.5)	Family	This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.93	0.71	-4.88	8	714	2012-10-02 20:12:17	2003-04-07 12:59:11	8	10	280	4	416	1012	121	149.50	27	62.75	CHANGED	llPPhNFSsVts...slYRSuaPpstNFsFLcs.L+L+oIlhLssEshsp-sLp..Fh-sppIchaalthsus+c.............hlslhscplpcsLcllLspcNaPlLlHCscG+HRTGlVIGCLR.KLppWslsuIhsEYppFous.ttchh-ppFIEhFssslhhcpss.tsthshtp	..............................................................................................................sP.NFuhVps...slYRS.u.h...P...p.....h..s...a....s...F..Lpp...Lp...L+o.llhLs....s......c...................s...p......p..............hp......Fhp.p.ps....I.p...h...h....p...h....t........h.p.s...p...pp........................................................................l.sp..p.t...l..h...psL.c.l.l...l....s......p.s..a...P..lLlHC.ppGp.cR.T.G.sl.l.u..s.h....R.+.l.Q.tWs....h.sul.hpE....Yp..p...asts.......p....s.palc.ap.p...............hh....................................................	0	143	269	372
+1956	PF03190	Thioredox_DsbH	DUF255;	Protein of unknown function, DUF255	Mifsud W	anon	Pfam-B_2331 (release 6.5)	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.18	0.71	-4.52	98	1287	2012-10-03 14:45:55	2003-04-07 12:59:11	10	21	1106	1	594	2317	1224	153.40	47	23.88	CHANGED	sNRLtpppSPYLLQHAcNPV-WaPWGcEAhpcA+ccs+PIhLSIGYusCHWCHVMt+ESFEDt-lApllNcpFVsIKVDREERPDlDplYMsssQhho.GpG......GWPLolFLTP.DtcPFauGTYFP.....c.....s+h...Gh.................PG......FhplLpplschWcp.c.+pplhpsuppl...hptLp	.............................N+LhpppSPYL.hQHA.pNP.........V......cWaPW.u..p.E.....A.h.pcA.+.p.c.s.+.P.I.hL.S.....l.G..Yu.sCH..WCH...VMt+.............E.S.F-Dt...-...l.A.t..l..h.N..c.p.F....V..s.l..K..V..........D......R....E....E.....R.............P....D....l.........D..............p.....l.Y...........M....s.........h.....s...............p.....s..........h....o......G..p....G..................GW.Ph.olFL...TP...-...t.c.......P....Fa..u.G..T..Y..aP.p.........sph........sh.................................su.........F.hpl.L...p.tltphWpp..c..+pclhppupplhptl.p...............................................................................................	0	217	426	530
+1958	PF03192	DUF257		Pyrococcus protein of unknown function, DUF257	Mifsud W	anon	Pfam-B_2788 (release 6.5)	Family	\N	25.00	25.00	25.90	29.10	23.40	22.10	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.13	0.70	-5.03	28	91	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	14	6	77	103	0	204.40	25	94.90	CHANGED	lp-hl.cph+hGEol...LlEYsS..shhchlhatl.lphh+-c...shsllIsDlhDoL.lhh........pplclhGlcsslh..csspVIKlG.GphshGNVlt+l..t.-.shah...ppYtptlpclht...pcs..hIsIlLGlE+lh.hh.pshh-hhhllptltpa.lsscc+..puhYFlNpsllcphsss.hl.hLEEluosV..lclspc...t....hplhKuhp.th.Gh...plpl	........h..chl.pph+hGEsV...LlEYsS.hshsclhhhtl.lphhpcc...shsllIsDlhDohhlhh........ppLchhGlcssh...cslpVIKlG..GphphGsl...lt+l.h.t-.shah...ppYpphlpclhp...pcp...hlslllGl-+lh.hht.psht-h.hhhlps.ltph..lGsccR..huhYFlNpsllpph..p.hlshLEEluosV..lclppc......sp.hhhplhKu.p.p..s..ph..h.......................	0	4	5	43
+1959	PF03193	DUF258		Protein of unknown function, DUF258	Mifsud W	anon	Pfam-B_2832 (release 6.5)	Family	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.98	0.71	-5.05	74	4240	2012-10-05 12:31:08	2003-04-07 12:59:11	11	13	3686	8	935	12978	6178	158.30	36	49.24	CHANGED	hcphhpthcslGYp.lhhhssp..sspulcpLpshLps.+hslhsGpSGVGKSoLlNtLhs...ph........................................phcTuplSpp.s+G+HTTspscLhtl....ssGGhllDTPGhpphslh..hstcplspsFsEhpphh....tpC+F+sCpH...tsEP..uCAVcpAl-pGplst.RYpsYhcllc	......................................................h....ht.Ypp..lGYp...lh..h..susp.........ptpu....l....c....t....L..........p....p....h...L....s.......s......+.......l....o......l...h..s.Gp..SG...VGKSo.L...l....NtLhs.....p..h...........................................................................................................................................p..h..p...T..u....-..l....S.....c......s.........u...+......G......+......H........T......T....s......p....s...c...L..h...p..l.....................p..G....G......h.....l....l...DTP..G..h....p..ph...s...lh..c...l.p...s.......-.p....l.spsFs..E..h...pphh..........tp.C+...F..R...s.CpH...t.p.E..P.......u..CAl....+..p..A.l.-....p.........G....p.....I...s...p...p...RacsYhplh.p........................................................................................................................................................................	0	336	638	814
+1960	PF03196	DUF261		Protein of unknown function, DUF261	Mifsud W	anon	Pfam-B_2687 (release 6.5)	Family	\N	26.10	26.10	26.30	26.40	22.40	26.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.68	0.71	-4.19	8	189	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	32	0	15	139	0	137.30	62	92.16	CHANGED	M.l.KhpppNt.....Ip+aGCYFLClhahh.lhKphc......Fssh-IslsYp+FluLGYI+.sNCaIlNPCtILuhaGIcocVRaESh....sYlssp.sEFEIoElKlcssshhHFlssss..pcVLYDS.LsLK.pGppaplsS+RlF+hp	..........MhIsKIKQsN+sLh.EIQKWGCYFLCLHYYsSlFKphE......FsAaEINsAYhRFlGLGYIK..SNCFIlNPCMILNYYGIRSSVRY...ESh.....sYLuAA.....NEFEISEVK...IccVN.GYHFIATKN..KEILYDS.LDLKs+GKlFKVTSKRIF+l.................	0	11	11	11
+1961	PF03235	DUF262		Protein of unknown function DUF262	Bateman A	anon	Pfam-B_3462 (release 6.5)	Family	\N	29.30	29.30	29.40	29.40	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.80	0.70	-4.38	194	2983	2012-10-01 20:12:50	2003-04-07 12:59:11	9	17	1749	0	669	2580	315	195.70	18	37.50	CHANGED	lppl..hsphp............................h...hlP..p............aQRsYs.W....ppcp.....hppLlcsl.....................................psah........lGsllh............................................ttt..tsphtllDGQQRLTolhh..............hhts........................................................................................................................................................t..hhtphhpttt..............................................pphppphhpshphhpp..................................................................................hh.h.h..................ps...shplFp...plNspGh....tLssh-..lh+shhh	...................................................................h.....htt......................h..hlP.t............aQR.sYs.W.......spcp.................hppLlcsl..............................................h.psa....lGsllh.............................................ppp......psph.llDGQQ....RLTolhh...........hlts....................................................................................................................................................................................................h...t.h....h.p...t.t..................................................................................................................p.t.tpphhp.h.phhtp..........................................................................................................................h.h...h.h...........................ts...s.....plFp....phN.stGh.Ls..-..lhpshh.h.............................................................................................................................................................................................................................................................	0	249	483	593
+1962	PF03237	Terminase_6	DUF264; 	Terminase-like family	Bateman A	anon	Pfam-B_3575 (release 6.5)	Family	This family represents a group of terminase proteins.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.95	0.70	-5.70	41	3063	2012-10-05 12:31:08	2003-04-07 12:59:11	10	17	2033	7	507	3449	4695	362.10	15	76.55	CHANGED	hhhtuppsGKTahhuhphhtpshtss......................psplhlu.sspsphph..............htthhhphspp.hhphphp........tp.hhh...........ssGup.ltahuhptt....stpuhpG.......t..hlahDEhhhhsc.thhpthtpshssptchh.........hhossssst+.hhshhssth.sp.................................................pth.hshp..................hshtDshptu.s.hh....................cplttphsspt..hpphhhupass.............ssuulFphtphphthstt..............s.tttphh........................huhDsu............tssDssuhhlh..............thssspahhlttpptpshshsthsstlpphhp...phssphlsl-sss.....sGpulhphlppth.................hshphs...........csKtshshthpsll...csu+lphsps..........phtshhpslcphhssss.........p..tt+sDhhsAhthAlhpt	.................................................................................................................................................................................................................................tuht.G.tT.h....h.h....s.....h........h....h....h....h....h..tpt.............................pthhhs..s.s..tt.p.ht...........................................hh...h.phh.....t...p............h..p.h.thp......................tp.hhh............................sGs.....p...l....hh.h.us...p....t.t...........shp.s.h...p..G.........................................hl...h.h.DE....h...hh.h............p.............t...............p......t......h....t....p...h....h...h...t....h......t...t..hh................................hho.s.s.s....s..............t....p......h...h............h...h.p..t...t.h.sp.........................................................................................h..hp...........................................h.sh.ts.s..h.....t..h.s.tp..hh......................................pp..l..t..t..p..h.s.spt........hpp...h..h..s..p..hhp............................stu..s..l...a.s..h...t..t..h..p...t..t...h..h.tt..............................................................s..s...t...t.hh.........................................huhD.u..................tss.D.ts.s.hhlh........................................h......ss......p..h.....h..h..l....t..t..h.........t........h.......p.........t......h......s.............t....t....t......p.....hl..t..p..hht..................ph.t.s..t..h.l.h.........h..-sps......................hu.tt.hh..p..lpp..h.............................h.h.h.s.................................ps+...t...h..h......t....htshh..........pt..tp.l..hst.............................h.t.h..t..lt.t..h...h.s.t.........................tp....s...Dhh.uhhhsh...........................................................................................................................................................................................................	0	161	327	421
+1963	PF03266	NTPase_1	DUF265;	NTPase	Mifsud W	anon	Pfam-B_4081 (release 6.5)	Family	This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [1]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [2]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [3].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.03	0.71	-4.54	38	349	2012-10-05 12:31:08	2003-04-07 12:59:11	10	9	303	2	181	414	99	157.30	29	79.34	CHANGED	+lhlTG.PGlGKTTLlpKlhctLppp.shplsGFhTtEVR..csGpRlGFcllslsoGccuhLA+ss.........tsts..+VG+YsVslps...h-plulsslcpt...ppsD...lllIDEIGsMELpopsFhpslcplLs.usps...lluslHcp.......llccl+pp.....sclap....lTpcN.................Rs...tlhpcll	.....................................lhlTG.s.G.lGKTTll.p+.....lh.ptLp..tt...sh..t..........ls....GFh.T..p..E....lR........pt..G..pR..h.GFcll..s...l.....s.Gc..c.s..Luphp..................tt.pl.GpY.s.V.p.lps...........a-pl.ulshLpp.h.........pssc.................llllDEIGtMEl..h..upt......Fhp...sl.....pph....Lp....ssps......llusl.ht..........hlppl+p.p.s...splhp....l...s.pN...Rs.l..pl.........................................................................................................................	0	69	108	142
+1965	PF03270	DUF269		Protein of unknown function, DUF269	Mifsud W	anon	Pfam-B_4172 (release 6.5)	Family	Members of this family may be involved in nitrogen fixation, since they are found within nitrogen fixation operons.	25.00	25.00	28.20	30.50	24.10	20.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.36	0.71	-4.11	41	182	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	157	3	85	173	7	121.40	47	78.61	CHANGED	a-shoDpplLsPaIloKEpRRpIPlhGDPDPsTlhRlchFYpAlAhsIEccTGhhssshhc..lsHEGFGRsllhsGRLVVls+sLR.DlHRFGF-SlpKLA-cGpKhlssulchIccaP-V.Ach	......W-scoDtc.LL.s.PaIloKEpRRp...IPllGDPDPps.lhRlchFYsAVulsIE+pTGlhssPhhc..hsHEGFGRhllhsGRLlVlsKpLR.DVHRFGF-oLpKLA-cGsKhVssulchIcpaP-VAp............	0	21	54	68
+1966	PF03189	Otopetrin	DUF270; 	Otopetrin	Mifsud W	anon	Pfam-B_2323 (release 6.5)	Family	\N	22.80	22.80	22.90	22.90	22.70	22.40	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.45	0.70	-5.48	12	606	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	83	0	443	578	1	212.80	17	64.99	CHANGED	YLRlGAlsFGlGshVY.GlEh...F.h.hsssCpslhluls.hhthlFshhQMpFIFhN..uclshtRa+hlARFGLMHhVAsNLshWhphlltEs...phEIhphtp.t...stpsshhpssptsstthsts.tttc........................................hh.th................................................................................................................................................................................hoppsss.......................................................th.hpstRhphhsshltssusaLasshlEYSLIsAslhahhWKplt.................h....tsshs+ps+phplDCsssppGlFhGIllllholIsllhaalLhpcst.phhAs..lsls-hlhaslshhA...llhuhhp..MRsLca......ppptcu.sLDsILLllu.sG.hlYushullushhshhpsp..sshlsllstlhpllQsslQolFILpuu+p+stusppsRspPG+pIlTFLLlsNluhahhpThEpt+u..uFpshhh-aYGhhsWollh+lohPLsIFYRF	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	124	164	306
+1967	PF03407	Nucleotid_trans	DUF271; 	Nucleotide-diphospho-sugar transferase	Bateman A	anon	Pfam-B_4460 (release 6.6)	Family	Proteins in this family have been been predicted to be nucleotide-diphospho-sugar transferases.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.26	0.70	-4.56	49	713	2012-10-03 05:28:31	2003-04-07 12:59:11	11	28	132	0	514	739	97	195.10	17	45.37	CHANGED	thlpphlVlAhDppshpts.pphtss.hhhh.h...........shs.tsphhtstsahphhhh+hplhpplLchGhshlhsDsDshWhcsPhshh.................ssDlhhss.Dthssp.spthpphh....................NsGhhal+uospohphhcphhpphtp..ss..........DQslhshhhpp.hh...........................hshphphLstshF.........shFhp...pp.pthps..............hhlHsshph...shp.....sKhpch	...................................................................................................................t...pphllhshDttshphh....t......th.t........h.hhh....................................tt.hhhst..sahp.hh..............h....h+hp.hl.t.plL...p..........h...G...a...s....hlh.sDsDlh..a..h..c...s..P.hs.hh...............................ssDl..hhss..Dth.t.s..t.......t.tphh.............................................................NsGhhah+s.ss...tsh..p.hhcpWh...p....th..tp.........st........................DQss.hsthht.t.........................................................................................hthphthl.sh.....hh................hh.t...........h.t.....................hp.sh.......t.......tKh...........................................................................................................................................................	0	210	362	473
+1968	PF03314	DUF273		Protein of unknown function, DUF273	Mifsud W	anon	Pfam-B_3636 (release 6.5)	Family	\N	30.00	30.00	30.20	30.20	29.20	29.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.72	0.70	-5.04	12	87	2012-10-03 05:28:31	2003-04-07 12:59:11	9	7	10	0	85	68	5	176.00	35	55.45	CHANGED	l+CYsKhHsYchllshDs-....ap..Csp.KDphFRRHCllAKlLssaD..slLFLDADhGVVNPpR+IEEal..ccslDIsFasRFhNWEItuGsYlsRNTpaAlshLpcFAsYE.+LPpSaHGoDNGAlHhaluE+lhPpso.clchC+.Khacp....SpsapDLaTYEuCI+slhGssscFs.KlRIL+K...............GT.GWARDGWLTs.hWpsch.DFMlHGWKsspLh.hPp..lts.ph	.......................................hpCY.t..tY.h.hh..ttt.................ht...C..p....p..........................hF+RHChh....uthL......p........p....hlhhlDuDhullNPpp..................hlE-al..............p.th.DlhhYsR..a..........h..........NaE....lhuGSYls+NT.auhphLpc.aAs.a.E...pLPp.u.hH.GoDNGAlH...............hhlhchhhPp...p......h......p..C..phapt....otshtshhsapsCh+.hhGttp.as..cl+IhpK...............Gp..uWsRD.WLTsshWs.p..DFMhHuhKppp..................................................................	0	32	41	85
+1970	PF03434	DUF276		DUF276 	Finn RD	anon	Pfam-B_4450 (release 6.6)	Family	This family is specific to Borrelia burgdorferi.  The protein is encoded on extra-chromosomal DNA.\	    This domain has no known function.	25.00	25.00	30.20	30.20	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.74	0.70	-5.44	3	157	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	28	0	12	138	0	260.50	73	99.62	CHANGED	MSIVFDSDFGILKRTI+DIVRoKREYLRVNYGINIDDNpSSIYNIIASSLALIEEEIINELNLFFSKMKPGGSYWAAIEEHISS.KSTTYSAVRNALLNL-GIEHsNIKSuAGKANIYLILKEDLLsTsKoNINsPEFKAKlWETLYLTTPSGTLLEGDIEIDGLNSTGQ+KSYKISLGKRKYVYMKVKYKLDLKNYLYLNIDSQIRDIYSRIISNNYhDMGISFEYQDFFAPVNEVKGIKFMEIuICIKDTDTESIoKISDSDFppNQDISIsDDTILLFNTT-RLLIDhD	....MSIVFDSDFGILKRTIKDIVRsKREYLRVNYGINIDDNpSSIYNIIASSLALIEEEIIsELNLFFSKMKPGGTYWAAIEEHISS.KSTTYSAVRsALLNL-GlEasNIKSuAGKANIYLILKEsLLDssKoNINssEFKAKLWETLYLTTPSGTLLEGDIEIDGLNSTGQ+KSYKISLGKRKYVYMKVKYKLDLKNYLYLNIDSQIRDIYSRIISNNYSDMGISFEYQDFFAPVNEVKGIKFMEIusCIKDTDTESIoKIsDSDFppNpDIsIsDDThLLFN.TTDRLLIDh................	0	8	8	8
+1971	PF03353	Lin-8	DUF278; Lin-8_Ec; Lin-8_Ce; 	Ras-mediated vulval-induction antagonist	Finn RD, Pollington J	anon	Pfam-B_3924 (release 6.5)	Family	LIN-8 is a nuclear protein, present at the sites of transcriptional repressor complexes, which interacts with LIN-35 Rb.Lin35 Rb is a product of the class B synMuv gene lin-35 which silences genes required for vulval specification through chromatin modification and remodelling [1]. The biological role of the interaction has not yet been determined however predictions have been made. The interaction shows that class A synMuv genes control vulval induction through the transcriptional regulation of gene expression. LIN-8 normally functions as part of a protein complex however when the complex is absent, other family members can partially replace LIN-8 activity [1].	25.00	25.00	25.30	25.30	23.00	24.00	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.15	0.70	-5.14	14	108	2009-09-11 05:18:49	2003-04-07 12:59:11	10	17	4	0	106	110	0	233.90	14	66.63	CHANGED	lohp-Yhphpppphhphsst...cstlKKVlLshlEcpPphWp..pssphttccWptlG.................................sEVacRTGpl........................lpssplpphappuKssL+p+L+psIhpK+hs+tssEtcLhcWEaYsah+YYRcsLtpaEApLRsc........hptptp.spscD-Ihh-shhp.......p.ppthEpsssss-h.s.Es.ht..sph.........ppsshpcsptsppshs..thsts.p.s............................sps.sushppsSpppps...........htsspp-ss...................sppIs.QspRLhpphPE+s+LlRcsLFcTllAh--t..-apssu-lFpDL.....At.psh++ppR	.........................................................................................................................................p..hth.....hlht.lpphsthht..pt.p.h..p..at.lu.................................hphatRTG.h..........................................hpht.lpphappuKptLpp+lp.hl..p.c.p.hs......tphEppL.hp.W.hY..h+aaRp....h.tphEtthptp.......................................................................................................................................................................................................................................................................................................................................................................................pp........................................................................................................................................................................	0	19	19	106
+1972	PF01709	Transcrip_reg	DUF28;	Transcriptional regulator	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1741 (release 4.1)	Family	This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1 [2]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3].	27.00	27.00	27.80	30.60	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.54	0.70	-5.23	257	5704	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	4795	3	1221	3365	2823	228.30	42	95.40	CHANGED	SKWsNIK++KutpDu+RuKlFoKlu+EIhlAAKt.G.G.sDPssNspLRsAlp+AKssNhPpDsI-RAIcKu.sG...t.....sussa-ElpY.....EGYGPuG.lAllV-slTDN+NRTsu-VRpsFoKs.GGsLGpsGSVuahFc++Ghlhhs.............tshsEDplh....-..ssl-....A.GA-Dl.................p.........s..-....-..............st...h..plhosssshtsVppuLcp.t....Gh...php.su-lshlP.psplpl...ss.-.......sspph.+LlDtLED.DDVQsVYsNh-	.................................pKWsNIcp+Kss......pDup+uKlasK.................hs+EIhlAAK..........t.G..G..sDPcsNspLRhsIc+AKpss.hP+-sI-RAIc+u.sGs........sspsacplpY.....EGaGPu.G....sA.llV-sLTDNpNRTsu.-VRssFsK..............s..G..G..N...lGss.GSVu.a.h.F-+pG.lIshp......................utDt..D.plh....E.tslE....A..Gs.-.DV..............p.........p.-....-............................ss.....h.pl.ho..ss.p-ht...pVpcALc..s...s........Gl...ch..p..suElphl..P..ps.p.spl..........ss.E...stpph.+LlDtLE.DpD.D.VQpVYpNh.....................	0	405	775	1031
+1974	PF03436	DUF281		Domain of unknown function (DUF281) 	Finn RD, Bateman A	anon	Pfam-B_4313 (release 6.6)	Family	This family of worm domain has no known function. The boundaries of the presumed domain are rather uncertain.	25.00	25.00	25.80	25.20	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.38	0.72	-3.91	10	42	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	4	0	39	43	0	58.60	30	28.03	CHANGED	sToDGCophtVpCshNsuh.Cs.............sstLhA-psuGshsssGossushAEuolTCQcDssW.DS	..........tsG.CsphtVpCphssuh..Cs.............sstLhhptsuGt.shsGss.su.p.u.psolTCssDuha...s...	0	20	20	39
+1975	PF03383	Serpentine_r_xa	DUF286; 	Caenorhabditis serpentine receptor-like protein, class xa	Mifsud W, Fenech M	anon	Pfam-B_2888 (release 6.6)	Family	This family contains various Caenorhabditis proteins, some of which are annotated as being serpentine receptors, mainly of the xa class.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.46	7	69	2012-10-03 04:04:29	2003-04-07 12:59:11	10	2	5	0	69	113	0	139.20	32	47.97	CHANGED	phPhlYIhsMslsGllsKls..hhlDhh..s.lh.PstsYtpYRphIGppl.TllsThsYhhPhaLshLMThpRh.IlhpPhcp..hFosp+lhlYshhlhIlshllLLIPahSpCslNFNAps..apsACAPc+HPlThhQNpaLIhlPhsshllNs	..................................hPhsYIhhMhhssh.l.phh....hh..hshh.................h.hh.hs..p......ttY................t..............t...............a.h.......p..h..hGp.h.TlhsohsYhhshhlslLMolpRlh.llhpPhsp..hFosp+lah.YC.h..h.ls...............l.....hsh.h......Ll.IPahSsC.lsFshhphsahosCuP.p+H..............P...lT.hapNpYh.....IhlPhsshhlN...............................................	0	16	20	69
+1976	PF03384	DUF287		Drosophila protein of unknown function, DUF287	Mifsud W	anon	Pfam-B_2926 (release 6.6)	Family	\N	19.30	19.30	21.30	21.30	19.10	17.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.64	0.72	-3.78	13	34	2009-09-11 13:33:43	2003-04-07 12:59:11	9	3	3	0	2	34	0	49.60	42	8.73	CHANGED	IsSIlpPs.-EKhLLccIh-spsscDDlshhDllVDuWccRLltEcKpIaacsla	..............IpSILtPsh-E+.hLpclh-c.pVDDsls.lD.llDSWccRLlsEcKpIaacsla..........	0	0	0	0
+1977	PF03385	DUF288		Protein of unknown function, DUF288	Mifsud W	anon	Pfam-B_3134 (release 6.6)	Family	\N	19.90	19.90	23.10	20.80	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.20	0.70	-6.00	8	118	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	38	0	100	113	35	184.50	29	31.56	CHANGED	RTTDIWRSFISQKILHLSGLTVSFVPTNAVQFRNAHsYLKDFKDEKQVYEDSGKMIEFLHNWpCospNSo.lEsCIppLlNDLVKVKLWGc-DApLMEMFLsDLKsMGFEFPpLls.sNah-PYuPSpNEToRDVNCRRMHLEF-Ll-P+Kp..sEsl++ApQKLNYFGDIlsWCNETGYSslospFPSPcQLA+pH-cSYVhQKchNSVLIVVNNYPWKYGMGLIQRLYQPYFATlIFCGSWYPEpFoslDNFTSTlaPINYIHMNPAEIcKGaFAYHCVTLVKELtLsNVpGYFLMuDDsVFNIWQRIDYSRVHHLsG.ShNhpNsWastspaGhpAAK+IlchVKsSTDsKlt-TWpKFDsGLpKauYhN.T-suEspMpSshGKSlSDF	.......................sDlhRuahuQ+lLa...G.hhlsFhP.ss.sh.phRssHs.hhhsFp-Ecpla.psGcll......cFL.pWp....st......l........cplhcLshshscpshWsppDhphhthaLpDLhslGap.Pplht........................................................................................................................................................................................................................................................................................................................................................................................................................................	1	48	63	94
+1978	PF01062	Bestrophin	Worm_family_8;DUF289; 	Bestrophin, RFP-TM, chloride channel	Bateman A, Moxon SJ	anon	[1]	Family	Bestrophin is a 68-kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a depressed light peak in the electrooculogram [1].  VMD2 encodes a 585-amino acid protein with an approximate mass of 68 kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif.  Bestrophin is a plasma membrane protein, localised to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of chloride channels, indicating a direct role for bestrophin in generating the light peak [1]. The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal RFP-TM domain implying important functional properties [2]. The bestrophins are four-pass transmembrane chloride-channel proteins [3], and the RFP-TM or bestrophin domain extends from the N-terminus through approximately 350 amino acids and contains all of the TM domains as well as nearly all reported disease causing mutations [4]. Interestingly, the RFP motif is not conserved evolutionarily back beyond Metazoa, neither is it in plant members.	24.20	23.40	24.60	23.60	22.80	23.30	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.74	0.70	-5.47	123	2221	2009-11-19 14:00:48	2003-04-07 12:59:11	16	18	1111	0	1116	1855	146	255.60	24	74.64	CHANGED	Mh..........Vpsp................shhclLhph+GSlhptlh........hcllhhhhhshllsh....hh..........................hahhhh..hhphshs.s..lls.sLulhLGFpssssYsRWWEuRphhuthlshsRslsppltsh...........lps.....ssp.............ctchl+ctlu...............asthhptt.LRshsstsc.....hpphl.....ppptp.tlp...st...pts.....shhlhhhhuppl.tps.tcpGp.hssh..........hhttltppLsphpsshuss-RlctTPlPhsYohllphslahahlhlshuh.p.........................slshhs.P.lhoslhsahahGhtplucpL.sPFGp-s.sDlsLstl...I-psltp	...................................................................................................................h.h.hh.h.p...u.o.lh......h..lh..........plhh.hhh.....hhlhh.h...................................................h...hh...hh.p.h..shh....s..........l.ls.....hluh....hL.u..F+ss..ss....as.R............ah-uRphhs.hh.tscslhp.h....hsh..............l.s...ptt..............................................htchh.+h.ls...............as.hhhph...h....L.....R.p....s.t........................................................ht.phl...............tpp.t...h.........tt.....tp.........s.....hlhhhh.t.t........l.....ttt....h...p......p..Gp...hs...sh.........................hh.h.pl..p.........plsphpshhush-+lt.sPlPhsYsh..............hlphslahahhhhPhuhh.............................................slt.hh..s...P.hhosl.hsaha....hu..htt...lupp.ltsPF.G.p........c.s..s..D...l.hstl...I-hsl.........................................................................	0	469	658	954
+1979	PF01724	DUF29		Domain of unknown function DUF29	Bashton M, Bateman A	anon	Pfam-B_2003 (release 4.1)	Family	This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Swiss:Q2RPE2, PDB:3fcn, is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerisation module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.	21.60	21.60	22.20	22.10	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.81	0.71	-4.34	89	805	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	164	1	289	1041	50	128.00	32	89.81	CHANGED	LY-pDahhWhpppsphL+p.....tch.spLDhpNLlEElEslG+p-+.cplpSpLtlLlhHLLKapaQ...s..p+pspSWpsoIpppRpcIpchLccsP.SLcsaLspt..hp....csYpcAhc.AtpEotlsh.........ptFPtpCPa..sh-plLspsahP	................hY-pDa.hWhppphphL+p........tph.splDhc.sLlEElEshG+p-+...cplpShLthLlhHLLKhpa...........pp.pspuWptsIpptRpplpch.Lpc.oP......S.L+.s.h..ltph.....hp.....csYpc.Ahp.utpcotls................t.FP...pp...sPa..sh.-.plLstpah.............................	0	57	198	269
+1980	PF03442	CBM_X2	DUF291;	Carbohydrate binding domain X2	Bateman A, Eberhardt R	anon	Bateman A	Domain	This domain binds to cellulose and to bacterial cell walls. It is found in glycosyl hydrolases and in scaffolding proteins of cellulosomes (multiprotein glycosyl hydrolase complexes). In the cellulosome it may aid cellulose degradation by anchoring the cellulosome to the bacterial cell wall and by binding it to its substrate [1]. This domain has an Ig-like fold [2].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.94	0.72	-4.15	41	261	2009-09-13 17:41:48	2003-04-07 12:59:11	9	72	123	1	115	262	11	84.50	29	12.79	CHANGED	oIsPoshsFcKsss..sDhslshshN.GNTLsu..lps.ssssLspGoDYol..SG.sslTlppuYLusl......ss...ussoLsFsFusGs...sssLsl	........................hsssshsFc+....ps..s...........s.....Dlslsl..shN..GN.o.lsu............lp...s..sspsLspGsD....YTl.....uG..ss....lTlppuYLusl........ss.....usssLohpFssGs...s.phpl............................	0	69	95	105
+1981	PF03398	Ist1	DUF292; 	Regulator of Vps4 activity in the MVB pathway	Mifsud W, Coggill P	anon	Pfam-B_3833 (release 6.6)	Family	ESCRT-I, -II, and -III are endosomal sorting complexes required for transporting proteins and carry out cargo sorting and vesicle formation in the multivesicular bodies, MVBs, pathway. These complexes are transiently recruited from the cytoplasm to the endosomal membrane where they bind transmembrane proteins previously marked for degradation by mono-ubiquitination. Assembly of ESCRT-III, a complex composed of at least four subunits (Vps2, Vps24, Vps20, Snf7), is intimately linked with MVB vesicle formation, its disassembly being an essential step in the MVB vesicle formation, a reaction that is carried out by Vps4, an AAA-type ATPase. The family Ist1 is a regulator of Vps4 activity; by interacting with Did2 and Vps4, Ist1 appears to regulate the recruitment and oligomerisation of Vps4. Together Ist1, Did2, and Vta1 form a network of interconnected regulatory proteins that modulate Vps4 activity, thereby regulating the flow of cargo through the MVB pathway [1].	32.50	32.50	33.40	33.00	32.30	32.00	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.90	0.71	-4.84	44	593	2009-09-13 16:20:19	2003-04-07 12:59:11	9	15	281	8	399	584	6	152.10	33	39.47	CHANGED	Kot.L+hulsRL+hlppK+pshs+ptR+-lApLLptG+p.................pp.A+lRVEplI+--hhlEshEllElYCELLlsRlsllpp.................ppsssslcEAlsollaAusRh.sEl.ELppl+shhspKa.G+-Fsttshs.t...sssVsp+llcKLs.spsPspchh.thLpEIAcpaslsa	.......................................+s.L+hslsRl+hl.ppK+...........p.....thspptR+-lAph.LpsG..+p............................................................ppA+lR....V.........EplI+--.hlpshEllElaC-LllsRhsllpp.................................................cphssslpE...Aluo..llaAusRh.s-ls...ELptl+...shhstKY.G+-Fstt.....shp.t.....tstVspc.lhcKLu.s........psPstthh.phLtEIAcpasl.a....................................	0	110	222	321
+1982	PF03444	HrcA_DNA-bdg	DUF293;	Winged helix-turn-helix transcription repressor, HrcA DNA-binding	Bateman A	anon	Bateman A	Family	This domain is always found with a pair of CBS domains Pfam:PF00571.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.48	0.72	-4.54	13	1056	2012-10-04 14:01:12	2003-04-07 12:59:11	10	4	1032	0	280	1296	281	76.20	43	22.68	CHANGED	pLTslQ+-ILpsLIsLYccp.spslKGcEIA-hlsRNPGTlRNQMQuLKuLGLV-GVPGP+GGYhPTscAY-sLslps.s	.................................lTpRQppILphII-h.Y..t.po...tcPV.G.S+sL..t..c..p..l..s......S..s....A....TIRN-MucLEchG.L.l.cp......ps.SuG.....RhPo.tuh........hsssh............................	0	77	176	236
+1983	PF03445	DUF294		Putative nucleotidyltransferase DUF294	Bateman A	anon	Bateman A	Family	This domain is found associated with Pfam:PF00571.  This region is uncharacterised, however it seems to be similar to Pfam:PF01909, conserving the DXD motif.\	\	      This strongly suggests that members of this family are also nucleotidyltransferases (Bateman A pers. obs.).	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.58	0.71	-4.56	86	1219	2012-10-02 22:47:23	2003-04-07 12:59:11	8	171	696	0	561	1623	276	130.00	27	18.27	CHANGED	pplsplhtslhtpG....spsptlspllsplsDtlhcRllpLshtpht......s..sssasalshGSpGRtEQhltTDQDNuLlhsD...........tsttptaatphupclspsLspsGashCsGslMAsNPpWptslspWcpphppWlppPs...sc	...................................p....thh.thhtps.h.p.sch..lsp.h...lutl...sc...t...hh...p+ll.c..L..s....tphus...............s..PssashlshGSpGRpEQhlhoDQDNAlllp-.......................tsptpttaFtpluchl...spsLtph.....GashCsGphMssNspWphshptWpphhtpWlttsp.........................................	0	301	440	518
+1984	PF03479	DUF296		Domain of unknown function (DUF296)	Bateman A, Dlakic M	anon	Pfam-B_796 (release 7.0) & Dlakic M	Domain	This putative domain is found in proteins that contain AT-hook motifs Pfam:PF02178, which strongly suggests a DNA-binding function for the proteins as a whole. There are three highly conserved histidine residues, eg at 117, 119 and 133 in Swiss:Q46QL5, which should be a structurally conserved metal-binding unit, based on structural comparison with known metal-binding structures. The proteins should work as trimers.	25.00	25.00	25.80	25.00	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.39	0.71	-4.49	113	1687	2009-11-26 14:38:53	2003-04-07 12:59:11	10	15	1088	11	617	1176	262	116.50	29	57.50	CHANGED	hcsallclssGp.................Dlhpslpp...aupccshtsuhl.ouhG.ulsssslph..........s.......tp..h..sshsh.cuphEIlSLsGolh..........s.t.tsshsHLHlslus.spGplhGGplh.Gsl.hssu-lhlhthshtthpp	..................................h.p.aslcltsGp.................Dlhpplts....Fup...p...p.p.l.p.s.shl.uusG.ulssl..sL+h...............s............................sp...tsshpl....pG.p.aEllSLsGolt.....................s.st.....hH.LHlsl.....u...s...s.p.........G...p......s..lGGHl...h.......G..sl..tsssElhlhshs.h....h...........................	0	140	390	516
+1985	PF03537	Glyco_hydro_114	DUF297; Glyco_hydro_114; GHL7;	Glycoside-hydrolase family GH114	Griffiths-Jones SR	anon	PRINTS	Family	This family is recognised as a glycosyl-hydrolase family, number 114.  It is endo-alpha-1,4-polygalactosaminidase, a rare enzyme. It is proposed to be TIM-barrel, the most common structure amongst the catalytic domains of glycosyl-hydrolases [1].	27.00	27.00	27.10	27.00	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.46	0.72	-4.19	128	403	2012-10-03 05:44:19	2003-04-07 12:59:11	8	12	334	6	208	401	21	78.40	24	25.17	CHANGED	ssshhpP..sss......ssWpaQLs.........us..........h.sss...........sss......slhslDhh.c.............ss.....tttltt.L..+sp...G....+tlICYhSuGshEs......aR....s.D.t.....s....p....hsts	.................................t.........t.s......tsath.Ls..........st..........h.pss.................ssh...clhslDhh.p........................hs.....tppltt...L..+sp..G..+hVlsYlssGshEs....aRs..h....pp.a...s................	0	87	139	182
+1986	PF03618	Kinase-PPPase	DUF299;	Kinase/pyrophosphorylase	Finn RD, Eberhardt R	anon	Pfam-B_3403 (release 7.0)	Family	This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity [1-3].	22.10	22.10	22.40	23.20	21.00	19.90	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.63	0.70	-4.89	121	2713	2009-09-10 22:59:03	2003-04-07 12:59:11	9	2	2465	0	532	1496	1541	253.70	38	92.63	CHANGED	lallSDuTGtTA-slu+AsluQF.......shp..h.phpphPalcspcplpcllpplpp...psu......llhaTlVssclpphlpppspthth.tlDlhsshlsslpphLGh.........ps.p....tpsGthHplscs....YacRI-AlpFulpaDDG.psscslpcADllLlGVSRouKTPsSlYLAh.pGlKsANlPLls...-.......splPcpLhph...ppKlhGLTIsP-RLtpIRppRhhsht...................upYushcplppElphAcplac+..uhshI-sTp+SIEEsAstIl	.....................lahlSDuoG.TAEhlu+AshuQF................................s..sp.....h..phhph..Palcsppchcp.llpp.lpp........ppu........lVhaTlVps-l+phlt.p.u.p.t.h....shDlhpslls.lppphth........................cP.p.....ps.u.tsH..t..L..sss....YapRIsAI-FultaDDGt.s.s.+.s.ltcADllLlGVSRouKTPhSlYLAh.hGl+sANhPlls...-.......lslPspLh..th.......pcK.lhGLTIsP-+LspIRc.ERhps..................................opYAshcphppEls.s-plhc+..shshIssTspSlEEhAspIl................	0	164	320	430
+1989	PF03625	DUF302		Domain of unknown function DUF302 	Yeats C	anon	Yeats C	Domain	Domain is found in an undescribed set of proteins. Normally occurs uniquely within a sequence, but is found as a tandem repeat (Swiss:Q9X8B8). Shows interesting phylogenetic distribution with majority of examples in bacteria and archaea, but also in in D.melanogaster (e.g. Swiss:Q9VA18).	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.08	0.72	-4.40	170	1152	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	862	4	381	987	109	63.90	27	39.52	CHANGED	clDhptshcptshp...........hpshpllhhsNPphupphhpts..plGhhLPp.+llVhc......psGpshlshhcP	..............................lDhttshpptshp.....................htshpllhhsNPp.......hus.hhp..tc..sp..lul.LPh.+lllhct...........ssGpshlshhp....................	0	118	258	338
+1990	PF03629	DUF303		Domain of unknown function (DUF303) 	Finn RD	anon	Pfam-B_3622 (release 7.0)	Family	Distribution of this domain seems limited to prokaryotes and viruses. 	21.20	5.70	21.30	5.80	21.10	5.40	hmmbuild  -o /dev/null --hand HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-12.04	0.70	-5.16	136	2378	2012-10-02 11:02:24	2003-04-07 12:59:11	13	60	784	11	391	2310	644	279.90	27	56.17	CHANGED	G-VWLsoGQSNMp.....h.ht............shts.sp..............pphtps..sp.PplRhh...ph........t..s.p............s.tp.............spWp.sostss....t.t.....h......................oAsuaaFu+pLtpp.l..slPlGLIs.suhGGoslE.....sWhstp..sh.tt..th....t.htt............t.....................................................................................................................................................................................................ssLYNuMlpPlt.sh................sl+GslWYQGEuNs.....t.t..................pYtphhsslIpsWRppa........s.......ps..-hP..FhhlQLu...........sahtt.............................st.ths.lR-sQ.tpshtpl.....sNsuhs...............sshD.....h...up.psI...............HPpsKpplGcRLAhhAhph	...............................................................................................................................................................................................................................................................................................................VhlhuGQSNh...........................uhup.uh..................s-hhcu......sp..PpI+.l..................pp.shp.....................s...............tt..........spapshhPtst....s.c..................h...........................su..uh.a.hA+...cLhshl.............sss.lhLls.sshGGSuhp.....shspss.........th..ts..s..s......t.................t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................psLY..ps...hlsts+..uh.................slhull.WhQGE.Dh....sss........................pas...t...h...Fss...hlppaRt.-.h........................................s..........ts.......slP.ahhs.phs............ahppp....................................h...........................................................................................................................................................p....................................................................................	0	191	307	348
+1991	PF03733	DUF307		Domain of unknown function (DUF307)	Yeats C	anon	Yeats C	Domain	Domain occurs as one or more copies in a small family of putative membrane proteins.	21.20	21.20	22.60	21.60	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.56	0.72	-3.53	122	2967	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1534	0	655	1690	93	52.80	40	43.34	CHANGED	hlhNllWhl.huG.halulualluullhslTIlG.......IPaGhtsa+lushsLhPFG+p	....hlhNIlWhl.hu.G.aahsLual.lu.ul.....ltsloIIG........IPh....Ghusa+lu.tluLhPaGpp.........	0	171	375	544
+1992	PF03729	DUF308	RUF1; 	Short repeat of unknown function (DUF308)	Yeats C	anon	Yeats C	Repeat	Family of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X  (#=hydrophobic).	25.00	15.00	25.00	15.00	24.90	14.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.70	0.72	-3.98	354	6171	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	1945	0	1223	3772	186	64.10	19	81.07	CHANGED	lhGllhlllGllslhhPhhsshsl....s.hllGhhhllsGlhpl.h.tshp.....pph.t....shhhhllhGllhllhG.lhllh	............................ullhllhGll.hl.h.t..Phh..uhh...sl........s.hl....lu...h...h...hllsGlhpl..h..tshp.......pph.................hh.hh.uhh.hhhuhhh..h..................................	0	391	835	1043
+1993	PF03745	DUF309		Domain of unknown function (DUF309)	Bateman A	anon	COG1547	Family	This domain is found in eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.	21.20	21.20	21.50	23.40	19.00	21.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.08	0.72	-4.52	100	762	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	716	5	231	570	211	62.40	35	37.77	CHANGED	sthptulphasptcaacuHEsLEthWh....pssss..c+phhQGllQlAVuhhH.hpcGNhpG...AhtLh	.........h..lphhhphas.ctcYFpCH-lLE-.hW+....ppssh.....ccshlhGLIphAsuhaH.hcRsNhpGAh+h................	1	68	158	208
+1994	PF01732	DUF31		Putative peptidase (DUF31)	Bashton M, Bateman A	anon	Pfam-B_2152 (release 4.1)	Domain	This domain has no known function. It is found in various hypothetical proteins and putative lipoproteins from mycoplasmas. It appears to be related to the superfamily of trypsin peptidases and so may have a peptidase function.	21.30	21.30	21.50	21.40	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.49	0.70	-5.13	40	325	2012-10-02 13:45:52	2003-04-07 12:59:11	11	4	69	0	65	293	0	366.40	20	54.21	CHANGED	s-hY+phhcpTFulpasstpp...............................................................p...............................................pttGTuWllDYptsp.........................sspss......hphYlATNlHVhstLhst.s.......................................................................................................................shpspspshsLs+hspssshpsphspsp..........ppsptphshhsts.........................................ssKplasAsDFlpp..ssp.h.t..........................................pphpphp.shstasDFAVlElchph.p.........................sspphhchlsss...................atthpsptpp......hphhs......pphhpp..htph..........................................hahlGY.....Psspss..............................................shahststth.tp.t.........sththsphptss..hs.p.thpsh.spsulscshlst............................t.....ppYtpaGhshhhpph.shtuGuSGShlhspssp....llGI....aau	..............................................................................-hYcphh.poaulphhs.ts..........................................................................................................................tt................................................tt..ts.GTsWIlDap..h...sp..........................s.s.c.s......h+aYhATNhHVhs.h......................................................................................................................................shpspstshsls+hpsss.p.hppphphss................ppph.phhhhp.p.....................................................p.......sh+tla..suh.D..F.lpp..pstphht....................................................ppppphp...shstasDFAVlElcaph...........................................ssppltchlsss.......Yt..sppppp......hpahs...........pphhpp...htph................................................hahhGY.....Psspps.............................t....................tpp...........Slahsts..ph.pp.h.............sth..tphptss...hp.t.thpsh..spsulhcshlst...........................................................h...hthGhphh..pph..s.tuGuSGS....lh..........sppsp....llGIaa...................................................................	0	47	61	63
+1995	PF03750	DUF310		Protein of unknown function (DUF310)	Bateman A	anon	COG1421	Family	This family contains a number of archaeal proteins that are completely uncharacterised. The proteins are between 130 and 160 amino acids long. Their C-terminus contains several conserved residues.	24.60	24.60	27.40	28.50	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.56	0.71	-3.91	10	220	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	215	0	73	182	9	122.60	25	86.48	CHANGED	hlsshsc.ssptLlcpAE+lG..chLuc.ssLsToQIRclaspV+s.....I-pcscshpp.......lppcLhhLKPKLAYpsGRhp........tulcsLhElLccslcpl.....scchc+..FcpFhcFFEAIVAYHRaYGG+p	....................................hptt................t..h......h.....t..................p..........l.oToQlRplhsh...l.sp.............lt...schppptp.t................pltpc...l...phL+s+hsYpsGRcp................sl+sF.h...c..h..l..p..csl..-.....tl................tcs.tcp......h.tcFscahEAllAY+Kahs............	0	32	46	62
+1997	PF03759	PRONE	DUF315; 	PRONE (Plant-specific Rop nucleotide exchanger)	Finn RD, Wood V, Mistry J	anon	Pfam-B_3610 (release 7.0)	Family	This is a functional guanine exchange factor (GEF) of plant Rho GTPase [3].	19.00	19.00	21.10	20.00	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.27	0.70	-5.91	16	263	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	22	6	163	260	0	316.50	52	68.73	CHANGED	tt.u-hEhMKERFuKLLLGEDMSGuGKGVsoALAlSNAITNLuAolFGpph+LEPhssE+KshW+REh-WLLSVsDaIVEFsPotQph.sG.sphEVMsoRsRoDLahNLPAL+KLDsMLl-hLDuFc-.TEFWYl-ps.............ttuu.cp..spRp-EKWWLPsP+VPPsGLSEpuR+pLppp+-ssNQlLKAAMAINuplLuEM-IP-SYlEoLPKsG+uuLGDsIYRhl.Ts-pFoP-plLssLDLSSEHcsL-lsNRlEAShalWRRKhpt+..........ssKS..oWustVp.h......h-KpclhtERAEoLLhpLKQRaPGLsQooLDhoKIQYNKDVGpAILESYSRVLESLAaslhuRI-DVLasDchs+pps	..........................s-hEhMKE+FuKLLLGEDMSGuGKGVsoALAlSNAITNLs................AolFGp..h+LEPhss-+KshW+REh-WLLSVs....DaIVEhsP.ohQph.sG.sphElMss+.RsDlhhNlPAL+KLDsMLl-hLDuFpc..sEFWYlcps........................tsss.ct....s.pRp--KWWLPsPpV.PssGLS-tsR+.Lppp+-sssQlLKAAMAINuplLsEM-lP-sYh-oLPK.........s....G...........+usLGD.lY+hl...Ts-pFsP-plLss.....l-...........LSoEHpsL...-lt...NRlEAuhhlW+++hp.pp....................ps+o.....oW.shVp............h-..Kp.ph.htcR...AEslLhhLKpRFPGLsQosLDhsKIQaN......+.............DVGpuILESYSRVLESLAaslhuRI-DlLhsDphspp.s..............................	0	21	94	128
+1998	PF03773	DUF318		Predicted permease	Bateman A	anon	COG0701	Family	This family of integral membrane proteins are predicted to be permeases of unknown specificity.	24.50	24.50	24.60	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.98	0.70	-5.44	12	3218	2009-09-14 00:13:01	2003-04-07 12:59:11	8	17	2210	0	803	2344	347	274.70	22	88.25	CHANGED	shlshh.slhh.hhlcsl.hLlhuhhluuhIpshlscphlhchLsc..s+hhuhhluulhGhlhshCsCuhlPlhtthhcpGsshssAhsFLhuuPhlN.lslhhshhshG..hplshhRllsuhlhulllGllhphhhptp........................hlhshp...............................h.hls.sph.hsshh.+ht.shh.....cshs.hhphh..hLllGshIAuslpsal.Ppshlhs.hGt.....sslhushlhhlluhlh.hsohs-sslstuLhpt.huhGsslAhLhhGshlsl.shhhlhphhtt+hlhhhlshlsl.shlsuhlhsh	.....................................................................................t...t...thh.h....hhlc.h.h..hll.l.uh....hlu..uhlpshls.......c...h..lh+h.L.sp.....sp...h..h...u..h.hh.us...h....hGhhhPhCpCuslPlhtuhhp.ptsshs.s.sh.s.FhhsuP..hl..N.P.h.slhhh.hh.shG......hp..hshh+....h..lsullhullhG..h...l.lthhhtpt............................................................................................................................h.............................................................................................................................t....h.....t..t...p...h.....t....t..h...t..h.hhh..........psh.p..hh.p.h.h...alll....Gsh...l.uu..........h..........h.......psa..l....Ppphhts...hut.........................ss.h.h....ul.hlh....h..lluhhh..l.sutush.ls....t....u.h..h...tt...hu.h.ushlAhlhhssh.lsl.plh.hh.pphht.h....+..hlhhhh.s.hl..hh.s.shl.huhlh..h........................................................................................................................................	0	295	561	699
+2001	PF03778	DUF321		Protein of unknown function (DUF321) 	Finn RD	anon	Pfam-B_876 (release 7.0)	Repeat	This family may be related to the FARP (FMRFamide) family, Pfam:PF01581.  Currently this repeat was only detectable in Arabidopsis thaliana. 	20.60	20.60	24.40	21.10	18.00	20.00	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.13	0.72	-6.26	0.72	-4.48	32	105	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	1	0	2	105	0	19.10	66	55.12	CHANGED	LRFWRENHGFoFLAtK.pla	LRFWRENaGFTFLAGK.pVY.	1	2	2	2
+2002	PF03780	Asp23	DUF322;	Asp23 family	Bateman A	anon	COG1302	Family	The alkaline shock protein Asp23 was identified as an alkaline shock protein [1] that was expressed in a sigmaB-dependent manner in Staphylococcus aureus.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-3.78	173	4865	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1784	0	734	2174	33	105.20	28	72.18	CHANGED	phGplpIuscVltpIsGlAup-l.GVhuhsus...hhsslschl.sp...cshs+GVpV.chsp.ctplslDlhlllcYGssIsclupplpcpVcpslcpMTGLcVspVNlpVpslp	..........................................................p..GplplsscVltp..I..sGhAsp.cl.Glhuhsut........hhsslt.c..hl..sp..........psh..s...+GV...p.V....ch..........s....cpplsl.DlhlllpYG.s.plsclupplpcpVppslcphT.ulp...l.s.pVNlpVpsl..................	0	308	520	657
+2003	PF03781	FGE-sulfatase	DUF323; 	Sulfatase-modifying factor enzyme 1	Bateman A, Wood V, Mistry J	anon	COG1262	Domain	This domain is found in eukaryotic proteins [1] required for post-translational sulfatase modification (SUMF1).  These proteins are associated with the rare disorder multiple sulfatase deficiency (MSD) [2]. The protein product of the SUMF1 gene is FGE, formylglycine (FGly),-generating enzyme, which is a sulfatase.  Sulfatases are enzymes essential for degradation and remodelling of sulfate esters, and formylglycine (FGly), the key catalytic in the active site, is unique to sulfatases [3]. FGE is localised to the endoplasmic reticulum (ER) and interacts with and modifies the unfolded form of newly synthesised sulfatases. FGE is a single-domain monomer with a surprising paucity of secondary structure that adopts a unique fold which is stabilised by two Ca2+ ions. The effect of all mutations found in MSD patients is explained by the FGE structure, providing a molecular basis for MSD. A redox-active disulfide bond is present in the active site of FGE. An oxidised cysteine residue, possibly cysteine sulfenic acid, has been detected that may allow formulation of a structure-based mechanism for FGly formation from cysteine residues in all sulfatases [4]. In Mycobacteria and Treponema denticola this enzyme functions as an iron(II)-dependent oxidoreductase [5,6].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.91	0.70	-5.03	22	4674	2009-01-15 18:05:59	2003-04-07 12:59:11	11	147	2003	22	1863	4765	2666	226.90	22	55.13	CHANGED	pssshVhlsGGsFth...Gs.....................tspEsPh+phpl.psFhIsch.VTstpatpFlpt...ssh................................................h....ht.hppspt......ttsspPVspVoa.DAhAYApWhuc.......................................RLPTEsEWEhAARuG....tuphasaGsphts.....................t.stttsstsstpt.ssPVssass..NshGLhDMhGNVWEWTsshap...........................t.s....sssh+Vl+GGuahst.....sthhRsuhR.s.t..tssstssplGFRssp	.........................................................................................................h.....h.l...s...G...h.h....G..........................................t....-....ts......c..p..lpl..ps...F..hhsph.V..T..stpa...t...tahpt........st............................................................................................................................................................................................................h.......p..........................................................................t............t...........pt..P......V......h..pVoa.-.At.s.....a.spWh.u..p.............................................................................................................R.....LPTEsE......W....E....h....A...A......+.u..s.....................t..t........h.....h..s.s.p.............................................................................................t..................t..t...........h.....s.....t....s...V...s....t.h.s.................s.sh..G.....l.a.-.hhGNVaEWst.s..at............................................................t................................t....s..t........t..l....h.+..G...Gu..ahs..........sth...hRss...hR....t................t.......t...........t....h.GFRhs........................................................................	0	719	1285	1627
+2004	PF03787	RAMPs	DUF324; 	RAMP superfamily	Bateman A	anon	COG1332, COG1567, COG1367	Family	The molecular function of these proteins is not yet known.  However, they have been identified and called the RAMP (Repair Associated Mysterious Proteins) superfamily. The members of this family have no known function they are around 300 amino acids in length and have several conserved motifs.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.47	0.70	-4.49	154	1749	2012-10-01 21:23:39	2003-04-07 12:59:11	10	11	493	0	736	1663	29	234.30	14	68.48	CHANGED	plpsloP.la......hGsu........................................................................................................................tssstshl.uool+GslR.....hhhc..................thht.........................t.tt.tttt..t.t..............................................................................................................................................................................................h.splF.....Gss........................................shtupltlpss.................................................................................................................................h..hh.hththptphthspt.t..................ap..hchh.tt.......................................................................tt..ppttphhtphLphh..........................thhslG....uppp.......hG.hGt..hp	............................................................................................................................................................................hhos..lhlGsu...................................................................................................................................................................................h....hp.t.h.t..s.......h.P...hIPG...SSlKG.tlR................shhp.............................................................................................................phht....................................................................................t......................................................................................................................................................................................................................................................................................................................................................................hhpplF.............Gsp..........................................s...htu...plhhp....D.s..h.h....................................................................................................................................................................................................................................................................................................................h..t...h..h.t..hp.h..p..h..t.lsp...pttst..........................................hp.....hchl.tt........................................................................................................................................................t....t............p....t.........h...t....h.hht.hhphh......................................t....htlG..utts.hGhGhh............................................................................................................................................................................................................................................................................................................................................................................................................................................	1	388	536	643
+2005	PF03804	DUF325		Viral domain of unknown function	Griffiths-Jones SR	anon	PRODOM	Family	\N	21.50	21.50	21.90	127.20	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.31	0.72	-4.26	6	14	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	14	0	0	14	0	72.40	66	48.77	CHANGED	l+FSLRLTpEaKENIVAHlcHLsRLRALIDGKVTpADVRRFGFsDRNALVuACMsVNVQsYs.PDuTI..RhQP	lKauLRLTpEYKENIlsHhDHLoRLRsLIDGhlpspDVpRFshhsRNsLlSACMplNVpsYh.PsuTIDMRhQP	0	0	0	0
+2006	PF03885	DUF327		Protein of unknown function (DUF327)	Bateman A	anon	COG1728	Family	The proteins in this family are around 140-170 residues in length. The proteins contain many conserved residues. with the most conserved motifs found in the central and C-terminal region. The function of these proteins is unknown.	25.80	25.80	26.50	34.10	24.90	25.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.80	0.71	-4.37	51	443	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	442	2	118	290	4	147.00	26	98.51	CHANGED	M+Ip............t.ppht.tshtpsptcpst.ss..psFtphh.sptcpcttp...........ccLppllscIcctGp+LscshshpsltpYKchlKcFLcpslppshplcpppuh....s.t..ps+haplVcplDc+LpcLsp..pllspc+cslsllspIsEIpGLllDlah	.......................................................t......t..tt..t.ct..sp.sp.....tsFspph..sptcccph.................-plpphlcpIsctGc+LtppholcslhpYKphVKpFLp.hlcsshphccppuh................p.th..psphhslV+pl-pcLp-Lsc..pllsscpsplclLspIsEIpGLllslh...	0	54	92	102
+2007	PF03883	DUF328		Protein of unknown function (DUF328)	Bateman A	anon	COG3022	Family	Members of this family are functionally uncharacterised. They are about 250 amino acids in length.	24.60	24.60	24.70	24.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.57	0.70	-5.08	127	2603	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2522	0	474	1849	1083	236.40	36	94.32	CHANGED	M.LlllSPAKsL.chp..ss..ss...tpho....pPphhcpuppLlchh.+plos...pclupLM.plS-cLAtLNhtRapsa....p...t..ps....u+...AlhAFs.GDVYpGL-ApoLspp.shsaAQp+LRILSGLYGlLRPLDhhpPYRLEMGT+Ls..s.pGpsLYpFWGsploptLspthtt........splllNLASsEYaKulc..ptl.pspllossFp-.K..sGp..hKlISaaAK+ARGhMsRallcpplsss-p..L+sF....shsGYtastphS	...................................MhIllSPAKshshp............ss....sh............tph.o..........Pph.h...sp...opp.L..l.cth....cpl.os.............splppL.h.plS......-.clAshNhtRapsap.................t.ps.....up.....AlhuFp.GslYp..uLps.cs......h..ocs...-h......casQpHLRlLSGLYGlLRP.L.Dh.hpPYRLE..MGs+..Lt..........sp....G....+............s...LYpFWssh..l...o.ptL.sctht..................cplllNLASsEYh+slcs......tpl.......ps..........c........llss.h.F...h.-pK.......sGc.....hKllS........aaAK+ARGhMsRall..c..N..p..l..p..p..s-p.Lp.sF.......shtGYhastp.S...........................	0	130	290	396
+2008	PF03884	DUF329		Domain of unknown function (DUF329)	Bateman A	anon	COG3024	Domain	The function of this short domain is unknown it contains four conserved cysteines and may therefore be involved in zinc binding.	19.80	19.80	19.80	19.90	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.34	0.72	-4.41	121	1426	2012-10-03 05:12:49	2003-04-07 12:59:11	9	3	1418	1	310	792	215	59.70	48	90.21	CHANGED	h..s........VpCPpCt+tl.Wt.ps.ta.RPFCScRCphIDLGcWAsEcapIPup........ss-t.sp-p	......sl....VsCPsCGKsV......sW......s..p.s..sa..RPFCScRCp.LIDLGcWAuEEppIPuss-.....-sDt...........................	0	71	164	240
+2009	PF03886	DUF330		Protein of unknown function (DUF330)	Bateman A, Sammut SJ	anon	COG3009	Family	The proteins in this family are uncharacterised. The proteins are 170-190 amino residues in length.	21.00	21.00	21.10	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-4.85	95	1859	2012-10-01 20:48:06	2003-04-07 12:59:11	8	5	1526	8	438	1301	80	157.30	22	77.37	CHANGED	YpL.......ssssssssssssss.....lhlssVslsshLspsplVhpp..ssspl.phscpspWAssLsptlppsLspsLspphssttlss.s.........ssssshplpls..lpcFcut....ssspshlsup..Wplhs...tp.......sp..........shss+s.hphptshsus.u....hsulVsAhspul.spLuppIA	............................................Y.L........stssstsssstst........hhLhlt.pVsls.c.hLs.ss..s..lV.hps......sss.p.h..shh.p..sshWAssLsptlpsp..LsssLspp....hsshslssts............hsssphpLpls....l..pp....F....pup................su..p....s......h...l...s..up....ahLhp.......p....................ut................lhpRs.Fp..l.pts.hs.ps..s........hss..hV.pu.hspuh.sphuspIs.................................................................	0	105	240	342
+2010	PF03889	DUF331		Domain of unknown function	Bateman A	anon	COG3036	Domain	Members of this family are uncharacterised proteins from a number of bacterial species.  The proteins range in size from 50-70 residues.	25.00	25.00	25.90	25.20	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.80	0.72	-4.67	20	635	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	633	0	89	304	9	39.20	62	53.07	CHANGED	GsI+.DNALcALVTSpLF+pRVEKsKKGKGSYpRKs......K+pG	...........GpIKDNAlcALl+DPLFRpRVEKsKKGKGSYpRKu......KH................	0	9	28	58
+2012	PF03891	DUF333		Domain of unknown function (DUF333)	Bateman A	anon	COG3042	Domain	This small domain of about 70 residues is found in a number of bacterial proteins.  It is found at the N-terminus the of Swiss:O28332 protein. The proteins containing this domain are uncharacterised.	25.00	25.00	26.20	25.40	23.10	24.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.61	0.72	-4.16	57	1338	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	848	0	141	468	11	48.40	44	56.10	CHANGED	luhA.NPA.......usaChptGGplpltppspG...phGhCpLPsGcthEEWsLaRppp	....................thsNPA.......us.CtphGGoLtsspph.p.G...shuhCtLP.sGcph-EWuLhRtsp.........	0	22	53	100
+2013	PF03904	DUF334		Domain of unknown function (DUF334)	Finn RD	anon	DOMO:DM04800;	Family	Staphylococcus aureus plasmid proteins with no characterised function.	21.40	21.40	21.70	22.20	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.64	0.70	-5.03	2	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	34	0	1	40	1	157.90	31	83.28	CHANGED	.hthQ.h.S.cs.KpNcps.NhQhpSK.TGT.SpphQpoLpNEELpELK+QNKLllKYluEhpEpQclREKE.ptIpSpLKcsTcDFps+uhKl+NDFVclLQcpLp+VssE-lc..lt+slYtVREE.cpMLpEVKpSHEHYQpRQK.LFTGIGAMLLVFMLFALIMTIGpDFMuFLHVDsLQNAIAuKlKASEGFhohlWYIAYGLPYlLAIGLFIhLYEWIRA+FHD	.........................................................................................................................p...pp.pth....phppTtccFh.p..s.phppDFlchlpcpLpcl..ss-..php.t..hpp-.lhc.p...pE.cphLp-.V+p...uhEchpppppplasuhsuhLhVFhlFsllMhhG.Dhh.............................................................hh....................................	0	0	1	1
+2015	PF03928	DUF336		Domain of unknown function (DUF336)	Bateman A, Moxon SJ	anon	COG3193	Family	This family contains uncharacterised sequences, including several GlcG proteins. The alignment contains many conserved motifs that are suggestive of cofactor binding and  enzymatic activity.	20.70	20.70	21.20	21.30	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.48	0.71	-4.35	36	2508	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	1635	13	741	1913	457	128.80	27	74.31	CHANGED	sslshpsAh....phspAAhttApphuht.lslAV.VDt.sGphls.hhRhsGAshtosclAtcKAaTAsshtt.....sTtphsptlps.ssshhtshsth.....sphshhGGGlPlh.hcG.tl.lGulGVSGs.osppDcthAptulpAl	.............................................................................................lohptAp..plht....suhpp.....Ap.c.........s...h...lslul..lDs..sG..p.hls..h.h..R..h....-s.u..s.....h.s..sclutcKA.hTAst.hcp...................................sottht..p..h....s..ps....sts.hhshtsth....................sthsshuG.GlPlh...hcG....p.........l....lG.ulGVSGs..sscpDtplApsult..h......................................	0	202	445	612
+2016	PF03929	PepSY_TM	DUF337;	PepSY-associated TM helix	Bateman A, Yeats C	anon	Yeats C	Family	This alignment represents a conserved TM helix found in family of bacterial proteins. The previous DUF337 alignment covered the whole (or most) of the protein. Analysis with dotter (E Sonnhammer) indicated that the same region was represented multiple times within the old alignment.	21.50	19.00	21.50	19.00	21.40	18.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.17	0.74	-7.28	0.74	-3.18	216	157	2012-10-01 23:59:14	2003-04-07 12:59:11	11	13	141	0	57	868	51	35.30	47	13.52	CHANGED	hhplHp.................hhshhsshhhllhsloGlhhh	.................sDLHKGRss........GssWtWhlDlhAlhhllFslTGlhLL.......	0	14	29	44
+2017	PF03937	Sdh5	DUF339; TPR_div1;	Flavinator of succinate dehydrogenase	Bateman A, Yeats C, McNeil M, Eberhardt R	anon	COG2938	Domain	This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle.\	Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans [1]. Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria [2].  This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true.	20.90	20.90	22.30	21.70	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.31	0.72	-4.29	149	1961	2012-09-24 13:32:29	2003-04-07 12:59:11	11	9	1889	6	589	1180	1046	73.20	35	68.49	CHANGED	cppRLhacu.RRGhhEhDllLssFhcpph..ssls-pchptac.pLLsts..D.DLapWlhsp........shPp....chph......tllpplp	.........p+tRlpaps.RRGMhElDlllhsFh-c..p..h..ssLo-s-hphF..cLL.-..ps.........D..sDLasWlhs+........spPs....chcht...thlchI............................	0	158	312	458
+2018	PF01784	NIF3	DUF34;	NIF3 (NGG1p interacting factor 3)	Bashton M, Bateman A	anon	Pfam-B_1006 (release 4.2)	Family	This family contains several NIF3 (NGG1p interacting factor 3) protein homologues. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown [1,2].	23.40	23.40	23.70	23.70	22.10	23.30	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.86	0.70	-4.80	122	4441	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	4063	30	1020	3147	628	264.00	27	92.17	CHANGED	clhphlcphhPhphu..p.sa.Dss.............................GL....ls............pp..........................plp+lhlslDso.pllccAlp......ts.sshllsHHP...l.ha................pshcplssp......htphlhpLlc.s...........sIslauhHTshDss.s.GhNshLA.chL.....slp.........shpsht......................................................................................................................thuhGhl.Gplsp.s....hohpphhthlpppl.th.........tt......lphs.........shspplp.....+VA..lsuGuGs..phlt..pAhptss..D..lalTG-l...........paHsshpA..ppt.....G......ls..llssGHatoEphhhpt.....ltchLppp.ht.......................l	.................................................................................lhphlpp.hhs.phtp..sa..D..s..s..................................GL.....plt.......thcp..........................plp.+....lhsul-soptll-cAlc......tt..sD.hllsH........Hs.......h.ha..............................+s.h.p...s.lt.ss........ptphlppLlp.p.....................................cIslauhHTs..l.......D..........s.......tst..GsNshLA.chL.............Glp..........shp.lp.........................................................................................................................................t.ulGhl.Gplsp...s.........hohtchspplcptL..sh.............ps.......................lchs....................s..sssp...lp.......+VA....lss...GuGp........shlp..pAh.pt.Gs.....D....salTG-l...........................pa+sspsA....hpp........G...............ls......hlssGHatoEph.hhpt.....lschLppt...tt.....................................................................................................	0	349	670	874
+2019	PF03956	DUF340		Membrane protein of unknown function (DUF340)	Bateman A	anon	COG2431	Family	Members of this family contain a conserved core of four predicted transmembrane segments.  Some members have an additional pair of N-terminal transmembrane helices. The functions of the proteins in this family are unknown.	23.80	23.80	24.00	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.34	0.71	-5.01	43	1369	2012-10-02 17:06:44	2003-04-07 12:59:11	8	2	1098	0	227	767	126	173.70	40	69.66	CHANGED	llsslllGhllGhhhhss.....hth..sphsphhLhhLlFhlGlpLtpsshsl+plh.ls++slhlslhslluollGGllsuhlL.slslppuLAluuGhGWYSLSGlllschhus........hhGulAFlsslhREllulhhlPllh+..hsp.suluhuGAToMDsTLPlIppsuGhcssslAlspGhlLollVPlLlshhhu	..................................l.husVllGhhlGhhthsh........lphs...spsSpas.L.hlLLFllGIpLtssu.hoL.+plh.LN++uh..l....lulls....lluSLlGGllsuhlL..s.........ls.lppuLAhASGFGWYSLSGIL.lo-t.aGP........hlGohAFhs-LhREllAlhhIPhLh+...tttss..AluhsGAToMDhTLPllp+.s.GGh.-.hVPhAIsaGFlLollVPlLlshFs.s.....................	0	68	135	189
+2020	PF03959	FSH1	DUF341; 	Serine hydrolase (FSH1)	Finn RD, Bateman A, Mistry J, Wood V	anon	DOMO:DM04042;	Family	This is a family of serine hydrolases [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.56	0.70	-4.89	52	906	2012-10-03 11:45:05	2003-04-07 12:59:11	8	40	298	2	698	2926	1726	210.90	22	69.79	CHANGED	Ms.......t.h+lLhLHGatQouphFptKsuul+KhLpc................sh-hsalsuPh.l..s.schs..........................sttsss.huWahpppt..................tsphhsh--ulchlpchlpc....................................pGP...FDGllGFSQGAsluuhlsshhpphh....................................ppP.h....KFslhhSGFp......ts................................app.........ha...ps.l...phPoLHlhGptDtllstp......+SptLhcthps........splltHsGGHalPsppthhpth	...............................................................................................................................................................h.......+lLsLHGhtps....u...p...hFp.....t...p..h...t..s...l..p..p..tl.pp...........................t.h.chsahsu.P...h.h....s......s.s..h................................................ttsshhs...W..at.tp.tt......................................................tthtsh....p.p.u....l....p.h....l..t...p..h....lp.c............................................................................................p.G.P......a......D....G.......l.......l.......GFSQ.GA.s..l.u..u..h..l.....h...t.h..p.p.h.h...............................................................................tts...h..........+.Fu.l...h.....h...u.G.h.h.s.........hs..t...............................................................................................hpt............hh........pt.l...........ph.P.ol.H.l..h..G...p.........p...D...hls............................t...u.tt....L..h.ph.hps...........stlh.p.H....s.u..G.H.h..l.Ptptt.h...h..........................................................................................................................	0	185	395	577
+2021	PF03961	DUF342		Protein of unknown function (DUF342)	Bateman A	anon	COG1315	Family	This family of bacterial proteins has no known function. The proteins are in the region of 500-600 amino acid residues in length.	32.40	32.40	32.40	32.40	31.80	32.30	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.29	0.70	-6.07	100	994	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	688	0	301	827	74	432.60	19	78.32	CHANGED	lplplusDcMpAtl..........plpss......sGpsl.......................shcclhptLpppsl.shGlpcptlpp...hltp.t.h.........hphllAcGp.PhsGpsuplphhhp.tppph.p.ttccs......plDh+sLsplhs..VptGphLh.c+lPsstGpsGhsVhGchl...sspsG+-htlt..h.G.....pustls.cDsphl.l.AshsGtshht.ps.t.....lpVs...sslplc.sVDlso.GNIp...........................FpG.sVhlpG....sVpsGhpVcAsGcIplt...GhV.-uAplpA.tGsIhlptGllGptp....................uplpA.pGslpspal.ptuplpAtsslhlpctlhpsplpussplhl....ptt+..GpllGGp.hputpplpst..lGu...................ptuspTplpl.uhs.sphpcph..ppLcpplpph...ppphpclppt.......lpth.p.pt.ttp......pthpchtpph....pphppplpplcpchp.plppplpph......tps.plpspc.plasuVplpls...stthphpcp.hsssphhh..psspl	.............................................................................................................h.ht.pth.A.h.........................lh.s......tth.h...........................hhpplhp.hltpttl..hhGl.p....c.....p...tlpc........hhtp.ttt..................ph.lApGhtPlpupsspl.h....hhc...............p..p.t.................ppt..........plD...h.+................p.h.s.hhhs...........Vc.....cs-hlh.ch.h...s.p..p.G.psGhslpGchl........s.hsu...p...-....s.....lh...h.G.......css....ths.......p..-.s...spl..h.As..hsGhshhp..pst........hsVp....shlpls......sV.shpT.GsIc...................................a.p.G.sl.hl.pG......sVtsGhplpAstslplt....Ghl...ppu.plp.A..pusIplppGlhuttt.......................................................................................upltA..ttslh.s....phh.psup.lpAtp....lhlp.phh....h.psplhs.tpplhl................p..stl.u.sp..hpstp.plhsh....lGs.....................th.ss..t.o.p.lps.shp.......phppph....pplpp.p...hpph.......ppth.plppt.........................ltph..p.t............th.p.hpchhpph....tphptphpphptph....plppphpph................................l.h.p.thh.sspl.ht....t....................................................................................................................................................	0	134	239	268
+2022	PF03966	Trm112p	DUF343; 	Trm112p-like protein	Bateman A	anon	COG2835	Domain	The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length.  The C terminus contains the strongest conservation.  Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [1]. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast [2]. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [2].	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.61	0.72	-3.61	69	2406	2012-10-03 10:42:43	2003-04-07 12:59:11	11	10	2242	11	804	1479	422	52.00	41	65.19	CHANGED	chpLLclLsCPhs+G........sL............................................................................p....hchtc.....spLlCpss..phsYPIc-G	....................................ch+LL-ILsC..P..ls+G.............L.................................................................................................................................t....astcp..........pELlC..c..t...s..pLAaPl+DG..............	0	241	477	650
+2023	PF03976	PPK2	DUF344; 	Polyphosphate kinase 2 (PPK2)	Bateman A, Albrecht M	anon	COG2326	Domain	Inorganic polyphosphate (polyP) plays a role in metabolism and regulation and has been proposed to serve as a energy source in a pre-ATP world.  In prokaryotes, the synthesis and utilisation of polyP are catalysed by PPK1, PPK2 and polyphosphatases.  Proteins with a single PPK2 domain catalyse polyP-dependent phosphorylation of ADP to ATP, whereas proteins containing 2 fused PPK2 domains phosphorylate AMP to ADP.\	      The structure of PPK2 from Pseudomonas aeruginosa has revealed a a 3-layer alpha/beta/alpha sandwich fold with an alpha-helical lid similar to the structures of microbial thymidylate kinases [3].	20.40	20.40	20.40	20.80	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.38	0.70	-5.07	10	2990	2012-10-05 12:31:08	2003-04-07 12:59:11	9	6	1855	12	886	2487	1001	226.10	37	80.64	CHANGED	pls+ccYcccLtcLQhELlKLQpWltpcGc+.lVllFEGRDAAGKGGsIKRlT-pLNPRssRlsALsAPT-cEpuQWYaQRYlpHLPAuGElVlFDRSWYNRAGVERVMGFCssppapcFhRclP-FE+MLscsGIhllKaWhuIScEEQhcRFpsRpcsPlKpWKlSPhDlcuRp+W-sYo+A+--MhsRTcTshAPWhVVcADDKK+ARLNsI++lLpulcYpchccs	.................................t..p+ppYcpp.Lp.pLQhc.Lhcl......Q.p..........h.l.......t.....p......p......s......p.....+.....llllFEGhDAAGKGGsIK+lh.p.tLsPRsh+Vsuls............t...P....o-c...Ep.........s............ph.........Y..h....Rah.p+LPs.........sG.....cI..slF..DRSWYsRsh..V..........E.........RV...............h...............G...........a...............s...........o.............p.....p..p.............a.............c....c..........h....hc............plspFEc.hL.s..c.sG.hhl...lKaahplSc-EQpcRFpp..Rhpc..P..h..KpW.K.....l.S.s.hDlcs.pc+W-cYp...pAhccMhtpTsTs.t....APWhllpusDK+.tARlsshchlLpp.l.ch.....h.................................................	0	253	565	757
+2024	PF03978	Borrelia_REV	DUF345; 	Borrelia burgdorferi REV protein	Finn RD, Moxon SJ	anon	Pfam-B_26177 (release 7.2)	Family	This family consists of several REV proteins from Borrelia burgdorferi (Lyme disease spirochete). The function of REV is unknown although it known that gene is induced during the ingesting of host blood suggesting a role in the metabolic activation of borreliae to adapt to physiological stimuli [1].	21.60	21.30	21.60	22.00	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.88	0.71	-4.51	6	40	2009-12-11 17:11:53	2003-04-07 12:59:11	8	1	21	0	4	39	4	144.40	56	92.53	CHANGED	MKNKNIhKLFFluML..FVhuCKsY.............VcEKKcIDSLhpuVSsLNNcsDcspFKsYK-KINcLKEsLKDluNA.ELcEKlLsLpsLFQDKLAAKLAALKAAKscIpuh...sDcDps.sKsKIWocAKLVGVTlhh.GSsToGpGs.......cMSK-AVEQ....IDcIIKFLEEGTN	.........................M+pKNIhKLFFsSML..FlMACKAY..............................................VEEKKpIDSLhpslssLpNctst.....p..pFpsYKpcINcLKEsLKDlGNA...ELcEKLLsLppLFQDKLAAKLAALKA..AKpcIpsh..............TDpDpshsKpcIWuEAKLVGVTlph.GSsosGpGs.......cMSK-AVEQ....I-KIIKFLEEGTN...........................................	2	4	4	4
+2025	PF03984	DUF346		Repeat of unknown function (DUF346)  	Yeats C	anon	Yeats C	Repeat	This repeat was found as seven tandem copies in one protein. It is predicted to be composed of beta-strands. Thus it is likely that it forms a beta-propeller structure. It is found in association with BNR repeats, which also form a  beta-propeller.	21.20	21.20	21.20	21.40	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.06	0.72	-4.50	10	31	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	15	0	18	32	1	39.70	39	21.81	CHANGED	sQQHVauRss-GsLtHWaWs.sssulpppsW..sGsluGsPsA	........VFuRGoDspLtH+WWp.sssuh.s.tsWt.lGGslsSsPsh..	0	8	11	12
+2026	PF03988	DUF347		Repeat of Unknown Function (DUF347) 	Yeats C	anon	Yeats C	Repeat	This repeat is found as four tandem repeats in a family of bacterial membrane proteins. Each repeat contains two transmembrane regions and a conserved tryptophan.	21.50	21.50	21.70	22.00	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.46	0.72	-4.08	170	1475	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	248	0	562	1404	64	55.80	28	80.30	CHANGED	hhaWlshlhopsLGsshGDhLs.c..s...LGlGhssuoslhsullssslshhhtppt...ts	.......hhaWlshlhopslGsshuDhlsc.....s...................LG..l.Gh.s..suohlhsullss.hlshh.hhspt...s.........	1	143	313	454
+2027	PF01796	DUF35		DUF35 OB-fold domain	Bashton M, Bateman A, Krishna SS	anon	Pfam-B_1390 (release 4.2)	Domain	This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins. The domain is approximately 70 amino acids long. The domain is duplicated in Swiss:O53566.  The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain and a C-terminal OB fold domain represented in this entry.  OB-folds are frequently found to bind nucleic acids suggesting this domain might bind to DNA or RNA.	24.20	24.20	24.30	24.20	24.00	24.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.43	0.72	-3.75	157	1861	2012-10-03 20:18:02	2003-04-07 12:59:11	12	19	530	0	752	1722	492	65.50	26	35.94	CHANGED	hhthu.GpGslhoaTssct..sstshh...........PaslulVcL.-..t.........Gs........clhupls........s.s.......ssp......t......lGttVcss.hp	........................hthu.spGslhoaolspt..s.ss.h............Pasl.AlVcL.-...-................Gs............plhupls.........sh.....................ssp.....t.l.t.........lGhpVcssa...........................	0	153	462	641
+2028	PF03994	DUF350		Domain of Unknown Function (DUF350) 	Yeats C	anon	Yeats C	Domain	This domain occurs in a small set of of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues.	20.60	20.60	20.80	20.60	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.36	0.72	-4.23	173	2291	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1116	0	490	1389	176	53.60	26	71.47	CHANGED	asllulllhhlshhlhch.lsP.hchtptIpp...s.NhAuulhhuuhhlulullluuul	................ahhlullh.hllh....hhlhph..ls....P...h..shhphItp..........s..NsAAulh....huushluhulhluush...........	0	138	280	375
+2029	PF03995	Inhibitor_I36	DUF351;	Peptidase inhibitor family I36	Yeats C, Bateman A	anon	Yeats C, Bateman A	Domain	This domain is currently only found in a small set of S. coelicolor secreted proteins. There are four conserved cysteines that probably form two disulphide bonds. Proteins 2SCK31.15C (Swiss:Q9ADK5) and SCO3675 (Swiss:Q9X8V7) also have probable beta-propellers at their C-termini. This family includes Swiss:P01077 a known peptidase inhibitor of known structure. This protein has a crystallin like fold Pfam:PF00030 and is distantly related by sequence.  It is not known whether other members of this family are peptidase inhibitors.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.52	0.72	-3.62	7	93	2012-10-01 23:14:22	2003-04-07 12:59:11	8	5	47	1	33	113	0	89.90	18	54.95	CHANGED	uhtcCPsGthChasussusGphhhs..sssstshGs.hssphtShhNptstssCsat.tsYss.....shhhsthshsRGt...h.sshsuslsuhphlpspptC	.......sCssGphClassss..asGshhpht....sss..............h.s.....s...h............s.s..........h....ss.p.sp..Shh.Np.osttsshYpptsats...........................................h.h...............................................	0	10	25	33
+2030	PF04001	Vhr1	DUF352; 	Transcription factor Vhr1	Finn RD	anon	DOMO_DM06473	Family	Vhr1 is a transcription factor which regulates the biotin-dependent expression of transporters VHT1 and BIO5 [1].	25.00	25.00	47.90	46.90	22.50	20.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.08	0.72	-4.07	6	53	2009-09-10 17:29:09	2003-04-07 12:59:11	8	1	38	0	31	51	0	94.00	66	16.65	CHANGED	spchothGsTH+IREpLNFsDEKKWKpFSSRRLELIDpFsLSp+KASEQD-NI+QIAshLRsEFsYPspsop-FEKLVTAAVQSVRRNRKRSpKpp	....t.p.su.GsTH+IR-pLNFpDE+KWKpFSSRRLELIDpFsLSp+KASEQDpNI+QIAsILRsEFsYPsohosEFEKLVTAAVQSVRRNRKRSpK+.h.	0	5	19	30
+2031	PF04007	DUF354		Protein of unknown function (DUF354)	Bateman A	anon	COG1817	Family	Members of this family are around 350 amino acids in length. They are found in archaebacteria and have no known function.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.11	0.70	-5.57	4	167	2012-10-03 16:42:29	2003-04-07 12:59:11	7	3	126	0	117	350	205	320.30	24	90.78	CHANGED	h+VWIDIsNuPHl+FF+slIpchc+cGh-lllTsRchGslscLlchhGFphpsIGKHG.sTLpcKLltsucRshtLochIspp+PcVulhKpshELPRlAFGLpIPSIhllDNEpAlstNKLhhP........LscpllhPcshDt.clhchGuD.N.Ip.apGhsElsslps.....a..-splLccLs..hccpphIVMRPEP.tuoYhsu..+cSILscIl-hLpchss..IllhPRsccQ+EIacta-.lhIPccslDsLoLhahuchhlGAGGTMNREAAlLGsPslSsYPGK.LLuVDKaLI-pGhhaHSsDscEIlp....hVhsNhthR+tl+sh....-c.hchIl-hVpshhc	..............................................................................................................................................lhlDlspss.al+hF+thlpcLcc.c...G...a.-..lh..l..TsR...c...h...s...pshc...LLc..ha..sl..sa...h...s..lG.p..pu....ss...hh.......tK...lht....h..p....R.....t.h.p.Lh.ch...h.p..p..............h.c...P....Dlhl.u.h....s....u.sp....s...s....+.l....u.hs...ls..h.....Psl.....hh.......hD.........s.........-...tu.....h..h................s+L.shP.............hssh.ll....sPtsh................htp..h...Gtc...p.lh..asG...hp..Ehsa.l...p.s............F.p.P.c....t...s.llc..c.LG.....lc...s.p.t..a.l..l....l...R..p.s.h...p.A.s.Y.sss.........pp..sl...h.........c....l..l...ct....Lp...c.h..sp...l.V..h......l....s...cp......p....p......p.....t..p........h......h........c.........p.......h........p....h......h........l..s.......c..s...l........c...h...h...s...Ll...ha...uclhlusGu.TM.spEAAl..LGsPsl...p...h...h.s.........h..pp.h..h.hp...t.h.h.hh..p......t...h..................................................................h............................................................................	1	28	75	96
+2032	PF04009	DUF356		Protein of unknown function (DUF356)	Bateman A	anon	COG1844	Family	Members of this family are around 120 amino acids in length and are found in some archaebacteria.  The function of this family is unknown.  However it contains a conserved motif IHPPAH that may be involved in its function.	29.50	29.50	30.40	115.80	25.00	29.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.37	0.72	-3.97	10	49	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	49	0	39	47	1	106.90	43	82.18	CHANGED	lllIRADshcKlpsALuDL-RauulpItGKPRIlsPshADcllppllGp.lR++s+sAsLVcl-pssscAIs+lR+IHPPAHllVlSsRa.-sYp-Lhcpas+h.cL.+	llLIRuDsa-KlpsALADlcRautlpItGKP+IIsPphADpllcpIlGp.l+KpsKsAslspl-psAs+AIsRlRKIHPPAHIlVlSsca.-sapcLhcpasphP.LK..	0	7	15	28
+2033	PF04010	DUF357		Protein of unknown function (DUF357)	Bateman A	anon	COG1849	Family	Members of this family are short (less than 100 amino acid) proteins found in archaebacteria.  The function of these proteins is unknown.	24.00	24.00	24.00	35.20	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.36	0.72	-4.28	41	162	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	151	2	105	158	72	71.80	33	50.27	CHANGED	c+Yhchlc-ALpplc........ts.httssc-hlchAcsYhcDu+aalc.pGDhlsALuslsYuaGhLDAutclGlhs	.............................+Yhchhc-ALpplc........t..htsssp-...h...lphAcsYhcDu+aahc..cGD..hlsAluslsYAaGhLDAstplGlh......	0	25	64	86
+2034	PF04019	DUF359		Protein of unknown function (DUF359)	Bateman A	anon	COG1909	Family	This family of archaebacterial proteins are about 170 amino acids in length.  They have no known function. The most conserved portion of the protein contains the sequence GEEDL that may be important for its function.	25.00	25.00	52.30	51.60	22.80	18.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.41	0.71	-4.73	31	147	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	144	0	99	150	82	122.20	34	69.31	CHANGED	VTp....sllcsGltPtlsllDsKT+Rp.hpppht......htphlpVcNPsGsIo.-llcslccu...htp.scsshIhVcGEEDLhslPsllhAP.s.ohVlYGQPs.pGlVllpVspchKpcspcll.cchptp	......sTtpllcsGlhPslullDtKT+Rp.spppht...........hhtphlcVpNPsGsIot-lhc.slcpu....htp...spsshlhVcGEEDLhslPsllhAPtG.sh..VlYGQPs.cGlVllpVspchKpcspcll.cphp..h...............	0	24	58	80
+2035	PF04021	Class_IIIsignal	DUF361; Type_III_signal; 	Class III signal peptide	Bateman A, Szabo, Z	anon	COG1991	Motif	This family of archaeal proteins contains.  an amino terminal motif QXSXEXXXL that has been suggested to be part of a class III signal sequence. With the Q being the +1 residue of the signal peptidase cleavage site [1]. Two members of this family are cleaved by a type IV pilin-like signal peptidase.	23.50	23.50	23.60	23.60	23.30	23.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.85	0.72	-7.04	0.72	-4.10	49	226	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	58	0	144	226	10	27.60	32	22.13	CHANGED	p+GQlSlEahlLlhulllsshlsshhhs	..p+GQlSlEahlLlhullllshlsshhh.........	0	19	44	103
+2036	PF04015	DUF362		Domain of unknown function (DUF362) 	Kerrison ND, Finn RD	anon	COG2006	Domain	Domain that is sometimes present in iron-sulphur proteins.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  --amino -o /dev/null --hand HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.45	0.70	-4.85	115	993	2012-10-02 00:55:42	2003-04-07 12:59:11	7	22	485	0	449	1069	99	221.70	23	62.70	CHANGED	+VllKPNllt....sps.Pp........ussTcPpllc.ullchl.t.ctGu..p..lhluDusuhs.......ssppshcpsGhtphsc....chGs..pllshspst.hhthtt............sthhpphtlspslh-.u..DhlIslPpLKsHshst.hThulKNhh.Ghlss................pKst...hH............................................................................t.pphsphls-lsph.h.....pPsL..sllDulhu....hpusGP.s.sGpsh....ph.sh.llAusDsl.AlDss.uspll	........................................................................................................................VhlK.phsp..........ts....................tshhcPthlcsll.chl..p..ph...G..u...p...hlssssshhs..................pthps..ht.tsGhp..hst..............s.s......tl.l......hc..s...phhp.h.h..................tsphhp.php..l.upslh-.....u.......DhlIsls+hK.s.Ht.h...ss....hsuulKNlh.Gssstt..................sKtt......hH........................................................................................ttpth.t...ctls-hsps.l...............+sph.........s.l..h.....ssl.hs.......h.s..uP...s...ssp.st..............hh..sl.lhAS.tD.sV.AlDtsssch........................................................................................................	1	226	385	422
+2037	PF04016	DUF364		Domain of unknown function (DUF364)	Kerrison ND, Finn RD, Eberhardt R	anon	COG2014	Family	This domain of unknown function has a PLP-dependent transferase-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the C-terminus of proteins containing DUF4213, Pfam:PF13938.	23.00	23.00	23.40	24.20	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.52	0.71	-4.88	60	351	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	267	6	183	356	38	129.70	21	50.59	CHANGED	ss.h-h.hthttsccVslVGt.......a.P..hlctlc.p...pstplhllEhsst....tth.h....ssttsptlLspsDslllTGoollN.pTl-pLLphsp..sstllllGPosshhPtshhshGlshluGsh..lhDs-tlhcslscGuustthpttsththhh	...............................tsp+VsllGh..........h.P..hlcplt..t.......tstplhlh-hss...........t.tphsh.................ssptsptllsp..sDhlllTGoollN.sTlsplLphs.c.....s..t.h.h..llhGPos.shhs.hhhthGhphlsu........p...hh.hh...................hh..........................	0	77	130	159
+2038	PF04033	DUF365		Domain of unknown function (DUF365)	Kerrison ND, Finn RD	anon	COG2028	Family	Archaeal domain of unknown function.	22.50	22.50	22.80	89.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.33	0.72	-4.00	5	11	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	11	1	9	15	0	94.70	52	69.01	CHANGED	MKlIFYASREDQGFaGEAEIERVEha-sPhcIlEKYGDcLFLTcEELK+Y.E+upcRWsu.....cu+RKRPWMVIcL+NIRKYc+VVKPKRFVPVuGRYV+E	.MKllFYASREsQGahGEAElEpVchapss.cIlcKYtDcLFLT.EElRcY.p+s.pcRWss.....tu+R++PWMVlhL+NIRKYs+VVKPKRFlsVuGRYl+-.	0	4	5	5
+2039	PF04017	DUF366		Domain of unknown function (DUF366)	Kerrison ND, Finn RD	anon	COG2029	Family	Archaeal domain of unknown function.	25.30	25.30	25.80	170.30	23.40	25.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.95	0.71	-5.01	15	67	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	66	6	53	69	18	186.10	43	97.22	CHANGED	M....hhlll--cl-YDGSQIpShWAapsFGlpGDSIVsFRGsC-Vch-cMlDlEDl+pcp.....IpScDMlHFIlEHFDp...DLchuhtRQRLLlull+EhLpch......GlcspRcGDDLYlss+KLSVSIATsSsVShKIHhGINVpocGsP..VsslGLpD....LGlcshp...plhccluppYscEh-cIc+DhpKsRs	............hlhhccplcYDGSpIpshWAacsFGlpsDSIVsFRGsscVcl-cMlDlcDl+tpp......IpSsDMlHFIlEHFDp...DLchshhRQRLhlsll+ElLpch......Glc.hpRcGDDLYhs....s....+KLSVSIAosSsVStKIHhGINVpscGsP..VpslGLp-.........lGlpshp.....clhccluptYscEhccIc+DhpKsR...	0	14	28	42
+2040	PF04034	DUF367		Domain of unknown function (DUF367)	Kerrison ND, Finn RD	anon	COG2042	Family	\N	23.80	23.80	24.20	29.50	22.90	23.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.59	0.71	-4.53	10	466	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	417	0	327	458	69	125.70	45	45.79	CHANGED	lVLoPhuctslSPcD+-ll-+pGlsVlDCSWs+l-ch.Fscl+s...cptRtLPaLVAANPVNYG+PtcLSolEAlAAsLYIlGhh-cAptLLS+FpWGcsFL-LNcELL-tYupscsS.EIhclppcaLp	..........lVLoPh.uppslSP.s.D.+pl....lppt.GluVlDCSWs+l..--...s..PFs+lpu.......p.p...R..LLPa.LVAANP....VNYG+Ph+LsCVEAlAAshhIs..G.ap-hApp.lLspFpWGcsFL-lNc-LL-tYutC.p.sspElhpsppcaL..............	0	111	190	275
+2041	PF04018	DUF368		Domain of unknown function (DUF368)	Kerrison ND, Finn RD	anon	COG2035	Family	Predicted transmembrane domain of unknown function.  Family members have between 6 and 9 predicted transmembrane segments.	24.90	24.90	25.50	27.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.75	0.70	-5.19	110	1391	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	1306	\N	249	911	878	250.90	32	87.16	CHANGED	M..GuADlVPGVSGGTIAhIsGIY-cLlsuIssls......phhphhhp...........tthtthhpthsh.FLlsLhhGlhhulholupll..saLLppaP...lhsauFFhGLIluSlhhlh+.p......................lpt..hshtp...l....lhhllGh.sluhh........ls...............................h........hsss.p...sssshhh..........................lFhuGhlAlsAMILPGISGSFlLLlLGhYssll.sAlpsh..........................slshlhlFuhGsllGLlsFo+lLpalLc+a+shTluhLsGhhlGSLttlW.....Pap.............t..hshhp...tslhshsa	............................hGhusllPGVSGGTlAhllGIY-chIsuluplh..pthc.hhp............................sh.FLlslhlGhllulhhhSpll.......paLLps........a....l.shhhFhGlIluolPhll+p.................................tpp.....hshtc........l..hhhl..h..uhll.s.hh.hs...................................................................................................h.................hssh.t...t.hssshlh.............................................................................................hhlAGhlAusAMlLPGlSGShlLLllGlYsshl.sulpsh..........................tLshlhsh....uhGslsGllshSKllsahLp.+a+shshthIlGlllGSlhhlh.....Phh..........................sss..h.hh.h.hh..........................	0	76	167	220
+2042	PF04126	Cyclophil_like	DUF369;	Cyclophilin-like	Kerrison ND, Finn RD, Eberhardt R	anon	COG2164	Family	This domain has a cyclophilin-like fold, consisting of an eight-stranded beta-barrel with an alpha helix located between the beta-2 and beta-3 strands and a 310 helix located between the beta-7 and beta-8 strands. The catalytic site found in human cyclophilin is not conserved in this domain, suggesting a different function for this domain [1,2].	20.30	20.30	20.30	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.60	0.71	-4.51	14	235	2012-10-02 15:38:38	2003-04-07 12:59:11	8	5	223	5	81	217	103	113.10	22	69.69	CHANGED	h+l+Ihhs.....ptcs.sELs-s...pTsctlhcuLPlcupsspWG-ElYFosslpss.-Esup-sV-hGDluYWsPG+AlClFFGsTPhS.ssc.pPASsVNlIGRlsssh.chlppVpcGspVtlc	.......................plclphs.....spphpupLt-s...tsucphhptL...Plsl.p.h.p.p..a..G..s..E...h.h.h..ph...Pt.p.l.s.hp.ss........s..t.s.s.s.p.sGDlsYasstss.....lslFY.tpt..............t.h..hGch.ts.........h................................................	0	35	56	71
+2043	PF01809	Haemolytic	DUF37;	Haemolytic domain	Bashton M, Bateman A, Eberhardt R	anon	Pfam-B_1485 (release 4.2)	Family	This domain has haemolytic activity [1]. It is found in short (73-103 amino acid) proteins and contains three conserved cysteine residues.	21.10	21.10	21.80	21.10	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.35	0.72	-4.36	219	3575	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	3453	\N	886	2340	1979	65.50	47	72.84	CHANGED	hppllltlI+hY....QhhISPl.h.s.ss.CRFhPTCSpYul-Alp+aGsh+GsaLulpRllRCHPa....ssGG.aDPV	....................pplhlthl+hYQth..I..SPl....h......s.....ss..C...RF.....h.....P.....TCSpYul-Alp++GshKGsaLultRILRC.HPa....stG..G..hDPV..............	1	320	605	769
+2044	PF04025	DUF370		Domain of unknown function (DUF370)	Kerrison ND, Finn RD	anon	COG2052	Family	Bacterial domain of unknown function.	21.20	21.20	21.70	21.50	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.12	0.72	-3.93	19	534	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	505	0	164	344	8	72.70	64	81.98	CHANGED	LlNIGFGNhVsusRllAIVsPcSAPlKRlhp-A+-pupLlDATpGR+TRAVIlhDSsHVILSAlQPETlupRl	.......LlNIGFGNIVSAsRllAIV...SP....E....SA....P....IKR....llQEAR-+GhLIDATYGR+TRAVIlhDSsH..VI.LSAlQPETlApRl...........	1	85	138	153
+2045	PF04027	DUF371		Domain of unknown function (DUF371)	Kerrison ND, Finn RD	anon	COG2090	Family	Archaeal domain of unknown function.	25.00	25.00	44.10	28.20	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.60	0.71	-4.49	19	131	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	127	1	86	127	18	128.60	38	81.94	CHANGED	l+A+GHcNVpApH+SThElT+DcaLTPpGDCIIGlsAD+uhsDlsccFKptl+cscth.lplhlcs.....sshpDplhGpGpscLoLscssshVhR+SsYl.ssRTlhIpAsKAAtDlsR-llctL+.cGsplhlplhV	..........lpu+GH.NVpApH+oTlElT+-saLTspGDCIlGlsAD+uhtDhspchKptl.psspt..lhlhlcs............ts.hh-hlhGpGsscLsh.spspclVhR+Ssal.ssRTlhlpAsKAApDlsR-llptL+.sssphplpl.....................	0	23	51	72
+2046	PF04036	DUF372		Domain of unknown function (DUF372)	Kerrison ND, Finn RD	anon	COG2098	Family	Domain of unknown function.	20.40	20.40	21.00	40.50	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.65	0.72	-4.49	15	84	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	82	14	60	90	6	38.00	56	31.52	CHANGED	ERAhFEAGIKLGALYHQFsGTPVu.coAsSLEpAIE-S	..EcAsFEAGIphGALaHQFsGTPVS...coscSLEpAIE-u..	0	11	41	52
+2047	PF04123	DUF373		Domain of unknown function (DUF373)	Kerrison ND, Finn RD	anon	COG2237	Family	Archaeal domain of unknown function.  Predicted to be an integral membrane protein with six transmembrane regions.	22.10	22.10	22.20	22.20	21.50	21.90	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.98	0.70	-5.42	35	156	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	130	0	101	157	110	341.20	29	93.44	CHANGED	M.chLVlsVDRDsDlGcKsGlpTPVlGR-sslcAAlcLulsDPEDSDsNslFuul+lY--Lc...sc.Gc..-VEVAsloGspcs.ulpuDhplucpLDpVLpphsss...ssllVoDGu-DEpllPlIpS+l.lsuVcRVVV+QupslEoTYYll....KcslsDschpphhL.lP.GllLLlaulhtlhsh..............sshslsslshllGhahLh+Ghul-chlpphhcphhtsh..t.clohlohlluhhllllGlltGhhsl.phtshsshhhhs..........alhshl.ahshuslh.shlG+ll-phlpschphhphlst.hhlhuhthllashssah.hs............hhhsslphhhhslssslllulhs	.....phLVlsVDhDDDlGcKsGlpoPllGR-sshcAAscLulsDPEDSDsNslasul+lYD-Lcpc...Gc..-VElAsloGspcs.ulpushplucplDplltphsss...tsllVoDGs-DEpllPlIpSRl.lsuVcRVVV+QucslEoTYYll....KchlsD.chpphhL.lP.GllLLlaulhtl.hsh..............sshshsslshllGhahl.h+Ghul-chlpphhcph.......h..G.plohlohlluhhllllGhltuhhtltshtsttshhhhs.................alhshlsahsh.uhlh.h.hG+ll-phlpp..ch.phhphlst.hhl...lulhhllhs.hsthhhsh.....................h.hssh.phhhhhlsshlllul..h.......................................	0	23	61	85
+2048	PF04028	DUF374		Domain of unknown function (DUF374)	Kerrison ND, Finn RD	anon	COG2121	Family	Bacterial domain of unknown function.	26.00	26.00	26.80	26.20	24.30	25.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.39	0.72	-4.74	79	649	2012-10-02 00:16:30	2003-04-07 12:59:11	8	4	572	0	167	448	385	78.70	34	33.22	CHANGED	hhshha..tp..........tphtsllSppcDG-llupslcthGhpslRGS..........os..+GGspAltphlctlc.pGtsl..ulTPDGP+GPtc	.......................hshha...tp...........tchhshlScpcDGEllApllcph.GhpslRGS............os+GGspALpphhctLc..pG..p.sl..slTsDGP+GPh......	0	71	123	147
+2050	PF04041	DUF377		Domain of unknown function (DUF377)	Kerrison ND, Finn RD, Mistry J	anon	COG2152	Family	This family contains many hypothetical proteins, some of which are predicted to be glycosyl hydrolases. This family was noted to belong to the Beta fructosidase superfamily in [1].	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.06	0.70	-5.71	8	965	2012-10-02 00:26:57	2003-04-07 12:59:11	8	6	499	13	330	923	112	286.00	27	80.25	CHANGED	hh+KhPs.PIlc.Po.hpGaDs+h................sFNPuVl.hcpch.....hVhlYRsps.cshsohRIGLuhSpDG......lpastcPEslhhPchphEhhG...lEDPRlsKlsccYhMTYTGhss+hsRlsluso+shloat+hs....shhs.Fshp....phho+sGslhPpKl.....sGcYlMaa+........sushaLAhS..sDtlpW-shhcs....lh..pscpsha-s...lKlGsGsPPlcsp-G..LVLhH...sss...s-phlYRlGsALhDt-sP.+...llhRocp.ILEPEt.aEhaGcVsNVVF.ssu.hV-ts.t+lllYYGuADptlGLAphs..lcclhchscc	................................................................................................................hh......................................................hhNsu...sh..httt..........................hhhhhRs............p....s........t.....t......h........h.................................hl....thu...S...pDG........................l.p.a.p.h......p....c...P....l...h..h....P...p....s.....p.............c....t.....h.....s......................h.DsRl.s..........t..h.....-....-.....t.....Y.....ah....sa.s...........u...........h...........s........t...........p...........s...........s..p..........h....u............l.u.........t.........o....p...D.h...t.....s...apphs..................................hh..s....s....................................+..ss....s..LF..P.c.........+l..........sG.....+.Yh.hhpR..............................tslalu.h.S..........sD........h.h.t.......W......s......t...p.pp.........................lh....ps.p..........t...h.a..cs.............h+l....GsGssPIcT.........p....c.......G.....WLhlYH.G......s....................sss...h.....t..Y...shGsh..L.L..DlccPs+.....lltRspp.llt..Pp....t......a...E..........p.......G...........V.s.N...VVFssus..l.........h.......c........t.......c.....p.lh.lYYGsADoh..hulAhhp..lpcllp....h.................................................................	0	164	266	307
+2051	PF04070	DUF378		Domain of unknown function (DUF378)	Kerrison ND, Finn RD	anon	COG2155	Family	Predicted transmembrane domain of unknown function.  The majority of the family have two predicted transmembrane regions.	25.00	25.00	32.20	32.10	24.30	22.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.00	0.72	-4.35	26	729	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	606	0	136	385	24	60.70	43	82.79	CHANGED	M+slshluLlLlIlGuLNWGLlGl..FpaDLVAulFG.Gps.....oshoRllYlLVGluulaplh.hhp	.........hphlphluLlLsIlGulNWGLlGh.....F..pFDLVutlF...Gss.......ohluRIIYhlVGluulYslhhh..t....	0	54	99	112
+2052	PF04038	DUF381		Domain of unknown function (DUF381)	Kerrison ND, Finn RD	anon	COG2098	Family	Archaeal domain of unknown function.  Strongly conserved YPLM motif.	25.00	25.00	32.00	31.60	16.90	16.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-8.89	0.72	-3.93	21	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	85	14	63	93	5	60.00	33	50.59	CHANGED	lpslsVcIcpshlcsphs..au.YoELsGcMLcVclplcYsusplpsphca..Eh-YPLMhlcc	..............scclpVcIcp-hlcppht..hu.YopLsGcML-Vclplch..psspstsplca..EhsYPLMhlc......	0	13	44	55
+2053	PF04063	DUF383		Domain of unknown function (DUF383)	Finn RD, Kerrison ND	anon	DOMO_DM06609;	Family	\N	23.50	23.50	23.50	23.60	22.10	23.40	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.26	0.71	-4.76	31	308	2009-09-11 22:59:18	2003-04-07 12:59:11	9	8	266	0	219	301	3	182.50	32	50.38	CHANGED	hsplsc.pps....ADhh...shLLuNLu+s-shsp.llshppp...............................................pth.tsppsl-pLhDsFsKGhp........................................sshN+..cAsaDYLuhlFAslS+hccGRpaFl...........................scQch-t.l.PlsKLlsFTE+t.SplRRcGVAoTIKNssFDtstH....hLLs.....--t.................lslLPalLLPlA.GsE..EhsE.E-hhsLPs-LQ..hLPsDKcR-sDssIhph	...........................................................................................h...lhp.pp....uc.hshlLuNLs+.t-shtp..llpht.pp..........................................................ps....hslspLhcsFsp......................................................tshNc..push.cYLu.lhuslSphtpuRpahl...........................sppchs...........lp+LlsaTcpt...SplRRt.GVsuTl+NssF-tppH....thLLs.......pp................................lslLPalLLPlu.GsE.................-hs-.E-h..tphPs-LQ..hL.P.-K..pR-sDssIhh.................................................................	0	72	119	184
+2054	PF04064	DUF384		Domain of unknown function (DUF384)	Finn RD, Kerrison ND	anon	DOMO_DM06609;	Family	\N	20.40	20.40	20.50	21.00	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.90	0.72	-4.40	29	294	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	252	0	203	282	2	57.90	36	15.57	CHANGED	oLhLLssT+pGRchhRs+sVYsIlREhHph....p....p-.cclt-sC-+......lVplLhRcEsptsh-p	......slhLLssT.+tGRchlRstslY.IlREhHph.....E...................p-...ppVtpuC-+...............lVplLhp-.E.tts................................	0	72	116	170
+2055	PF04074	DUF386		Domain of unknown function (DUF386)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family consists of conserved hypothetical proteins,  typically about 150 amino acids in length, with no known  function.	20.10	20.10	20.50	20.50	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.79	0.71	-4.70	13	3287	2012-10-10 13:59:34	2003-04-07 12:59:11	7	3	1492	8	258	1385	24	148.30	31	97.21	CHANGED	M.Iluclsphshhhuls.tlpcsl-aLpspshssLssG+a-IcGDplahsVhphpTpsssscphEsH++YlDlQlllpGpEpItaussht..shps.psas-pcDltahtsscscptlpLpsGpFslFaPt-sH+Ptshsss.sppl+KlVlKVtls	....................................................................M.Ih.splp.p..h...p....h....t...l..sst.lpcu..l....-..a..l.ps..........p......t..hs....sht.s...G...+..h-..l.....c...........G...c.plFhpl...p...p..Tp.s.st..p..pp.hEhHc+YlDIQllL.p.G.p.E.t.hsaussss...st...ps..ps.a.pc...-cD.l.t...a.h............s........s..p...s.....E...p..hl..t.L..p.....s..GpFs.lFaPt-sH+Ptsh.s..s...p.....s.......t.......t.......l..+KlVlKVth.t.........................	0	59	125	184
+2056	PF04079	DUF387		Putative transcriptional regulators (Ypuh-like)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family of conserved bacterial proteins are thought to possibly be helix-turn-helix type transcriptional regulators.	27.40	27.40	27.90	27.80	27.00	27.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.71	0.71	-4.86	139	3001	2012-10-04 14:01:12	2003-04-07 12:59:11	11	3	2904	3	769	2172	2160	158.50	36	73.66	CHANGED	shlEAlLFsuuc...P.lolppLsplh...........s...tsplpphlpcLppcY..................ttps+.Glplhch.ussaphtT+schuphlpchhpp..t..tcLSpAuLETLAlIAY+Q.PlTRu-I-plR.GVs.usshlppLhc+sLlcptG+pcs.sGRPhL.YsTTcpFLchFGLps..Lc-LP....sl	...........................t.hlEAlLFs...uu-...s.lshcpLscllt....hs...............splpphLpcLtpcY.......................................p.s.p..GlpLhcs.us..saphtT+schuphlpch.hpp......t...ptpLSpAALETLAIIAY+Q.PlTRu-I-p...IR.GVs...ossslppLht+sLIcts....G.....+p.-.s....sG..RPhL...YsTTctFL-hFGLps.Lc-LPs...................	0	268	528	663
+2057	PF04076	BOF	DUF388; 	Bacterial OB fold (BOF) protein	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Proteins in this family form an OB-fold.  Analysis of the predicted binding site of BOF family proteins implies that they lack nucleic acid-binding properties [1].  They contain an predicted N-terminal signal peptide which indicates that they localise in the periplasm where they may function to bind proteins, small molecules, or other typical OB-fold ligands [1]. As hypothesised for the distantly related OB-fold containing bacterial enterotoxins, the loss of nucleotide-binding function and the rapid evolution of the BOF ligand-binding site may be associated with the presence of BOF proteins in mobile genetic elements and their potential role in bacterial pathogenicity [1].	23.60	23.60	23.70	23.90	23.50	23.50	hmmbuild  --amino -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.10	0.72	-4.20	7	1522	2012-10-03 20:18:02	2003-04-07 12:59:11	8	1	890	1	148	625	10	102.00	40	81.34	CHANGED	uhs...........tGGFpGss.sstsoVctAhphtDDs.VsLcGsIlcplscDhY.FRDsoG.pIpl-IccphasG.plpscshlpIpGclD.+chsps-lDVctlpK	...............................ttts.......s.s.ps.tsG..ap..G..ss.....u.ph..h..T...Vcp...A...K..s...h...+D-sh.....VoL+GNllc...+l..u...-DpYlF+DsoG.pIsV-IDcc.ha...s...G.h.s.VsPc.spVcIpGclD...Kc.h..s.s.s.cl-VcplpK...................	0	16	45	102
+2058	PF01837	DUF39		Domain of unknown function DUF39	Bateman A	anon	Pfam-B_7373 (release 4.0)	Domain	This presumed domain is about is about 360 residues long. The function of this domain is unknown. It is found in some proteins that have two C-terminal CBS Pfam:PF00571 domains. There are also proteins that contain two inserted Fe4S domains near the C-terminal end of the domain.  The protein Swiss:O26943 has been misannotated as an inosine monophosphate dehydrogenase based on the similarity to the CBS domains.	25.00	25.00	42.10	41.80	19.00	18.70	hmmbuild  -o /dev/null --hand HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.94	0.70	-5.79	75	219	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	176	0	141	228	13	356.80	43	84.63	CHANGED	AlVlTAEEhhshVc-.GhppssccVDVVTTGTFusMsSSGAhlNhGa.o-PsI+h..p+saLNGVsAYuG......luAVDsYlGATphs-pss................pYGGGHVIcDLluGKplcLcApuhsTDCYPR+pl-splTl--lspAhLhNPRNuYQNYssulNsu..-+sl.aTYhG..sLhPphGNssYSsuGpLuPLhND......PthcsIGlGTRIFLGGutGYlshpGTQHss.........Phssh.uTLhlhGDhKpMsscalRGshhpuYGsoLhlGlGlPIPlLsE-lhptsulpDcDIhsPllDau..hsppsRs.slutVoYu-L....................................................................+SGpI....plpG+cV....p.TuslSShthAcclApcLKchIppGcFhL	.AVVlTAEEhhphVc-.GhppuAc-VDVVTTGTFusMsSSGAhlNhGH.o-Psl+h..p+saLNsV.AYuG......luAVDhYlGATphs-sss................cYGGGHVI-DLl.uGKplcLcApuhuTDCYPR+pl-spIol--lNpAhLhNPRNsYQNYssulNsu..c+sl.aTYhG..sLpPphGNssYSssGpLSPLhND......PthcoIGlGTRIFLGGu.GYlhhpGTQHsPt...........ssh.uTLhlh.GDhKpMsscalRGshhpuYGsoLhlGlGlPIPlLNE-lhptsulpDcDIhsPllDau..hPpps+s.sluhVoYu-L..........................................................................+SGpI.........plpG+cV......TuslSShhhAcclApcLKpWIppGcFhL..................	0	48	104	129
+2059	PF04094	DUF390		Protein of unknown function (DUF390)	Bateman A	anon	Pfam-B_1698 (release 7.3)	Family	This is a family of long proteins currently only found in the rice genome. They have no known function. However they may be some kind of transposable element.	19.60	19.60	19.60	19.60	19.10	19.40	hmmbuild  -o /dev/null HMM SEED	828	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.48	0.70	-13.45	0.70	-6.49	2	813	2009-01-15 18:05:59	2003-04-07 12:59:11	9	20	6	0	486	813	0	267.70	29	75.06	CHANGED	MRTaQGhpWDWsPEDF+hlVQRVLNLsSVEASLIPQtlLPLCsDP-RAsILTIM.tVGAStERA.+GHDGAGGSRRGEQSTPGGGRASGsRDtGPGuSRPADARGKRKQtGTPsPSPPRGGGAVRASSRRPEGAsPTSQPEGERKKKRhpKMGtsp.utGs..p..thph...................................h.shSEIPSRPSRHSKSGpSEAE-sAsAEARRREuDRREAADRLREAEEAAQ-AsRsRQAEEsAREEA.RhRpAtEusRE.cAu.RtcpAh............sp.uPsPossttsTTStAstDEAAGs.LGPsPSGDA.DpPusGshP-SGTSIGGPSRAAsoPRRL..hPShAPLsAEPLLQALAAsNTTVLDGLSAQhEsLQAERAELDAAWARVEEGRRSVEAMVEhGRKAHRRHsSELEsR++sLAEIA+EVEEERtsALIATTVhNEspDsLRLQYGShtAELcKKLDAApGVLDAAAAREpRAAEsEAASRpRE.ALEARAhALEERApshERDhADREAAVsIREATLAAHEAACAEEE.ALRLREDsLTERtRuLEtAEuAAQpLADSL.LREAApEEQARRNLEGARAcRAALsQRsAELEARAKELDARA+SGGAAsG-uDLAARLAAAEHoIA-LQsALDSSAGcVEALRLAGEVGPGMLhDAVSRLDpAGRQsGLWtGRssKYAANQGGLAQRLScMAGsLQRLPEELEcTIKSSSRDLApGAVELVLASYQARDPsFSPWhAL-EFPPGTEDusRAQVRDAAspIVcSF-GoAPRLsFA.sSDEEGsssGAsDuDDEAGDPGAS	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1	1	1
+2061	PF04134	DUF393		Protein of unknown function, DUF393	Mifsud W	anon	COG3011	Family	Members of this family have two highly conserved cysteine residues near their N-terminus. The function of these proteins is unknown.	25.60	25.60	25.60	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-11.11	0.71	-2.97	156	1577	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	1266	0	502	1346	1808	108.70	23	68.72	CHANGED	llaDGsCsLCstts..phltct.....Dp.t........t...plpassl....psststphh...........................t..s.ls..hpphpsh........lh....tsp...........................hh.ps....scAhhpl.hptlsh...hthlthhhh..lPth..ltchhY.phlAcpRaphhup	...............lhaDGsCshCsshsphlhpp......Dt.t.........t..phpassl..........psptstp..h...............................................................tt.s.ls......hpphpsh..........lhh...pssp.............................haht....ssA.hhpl..hp.....t..lst.......hphl.s.....hh.hh....h.....Phh....ltchsY.chhApsRhch..............................	0	152	315	430
+2063	PF04143	Sulf_transp	DUF395;	Sulphur transport	Bateman A	anon	Pfam-B_2577 (release 7.3)	Family	This is an integral membrane protein. It is predicted to have a function in the transport of sulphur-containing molecules [1].  It contains several conserved glycines and an invariant cysteine that is probably an important functional residue.	22.00	22.00	22.10	22.00	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.05	0.72	-3.93	106	5952	2009-09-11 12:44:05	2003-04-07 12:59:11	9	11	2209	0	1539	4246	1254	43.90	30	23.66	CHANGED	hhthllG.GhlhGhGhtluuuCssushhssssshsh.uhlshhuh	.............tsllG.GllhGhGhsLAGGCssGshhsussshsh..uhlshls.......................	0	487	974	1295
+2064	PF04148	Erv26	DUF396; 	Transmembrane adaptor Erv26	Wood V, Finn RD	anon	Pfam-B_22900 (release 7.3);	Family	Erv26 is an integral membrane protein that is packed into COPII vesicles and cycles between the ER and Golgi compartments.  It directs pro-alkaline phosphatase into endoplasmic reticulum-derived COPII transport vesicles [1].	22.20	22.20	22.80	22.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.64	0.70	-4.96	19	254	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	225	0	176	237	4	186.10	38	87.32	CHANGED	M.lL.LLuYlGsllGFsFLTLuIASGLYYlSELVEEHo..s+RhLpRhIYslIslhlLLhlhDpFPapLolhSIsoahVYhpNL.+cFPhlpLouPhFllSClLVllNHaLWFcaFsp..........s...s.php.....Y.....t....hsoFsEVsSaFulCVWlVPFALFVSLSAuDNVLPotspptsstt.............................s..t...+p+spGLhKsllsslRchl	.....................M.hl.llualuhhlthhFlTLul..................A......uGLYYLuELlEEaTshs+RllphhIahhhsl.hlhLhlh-pFPhh.hsh.hulhopllYht.L..ppFPalp.L..ouP..FlhSClLV.llNHaLhFpa.Fsp...............................................h.sFsE.lhuaFslClWllPFAlFVSLSAs..-NVLPohspt.s.................................................+t+t.Ghh.slhs.h+t..h..........................................................	0	59	97	141
+2065	PF04149	DUF397		Domain of unknown function (DUF397)	Bateman A	anon	Pfam-B_3066 (release 7.3)	Domain	The function of this family is unknown. It has been suggested that some members of this family are regulators of transcription. In  particular, it is thought that this may regulator of antibiotic production in Streptomyces coelicolor [1].  	19.70	19.70	19.80	20.00	18.90	19.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.82	0.72	-4.39	107	1426	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	87	0	637	1558	2	53.40	37	77.67	CHANGED	pspW+KSShS...........................sssusCVEV.A.......................ssss......s.lu.VRDSK.......c.P.sGPsLsassstWsuFlsus+s	...........................................t.htWpKSSaS...........ssuusCVEl.A.................t.hss.............s.lslRDSK.......s.s...sGP....sLhhssstWsuFlsusp................	0	143	532	615
+2066	PF04187	DUF399		Protein of unknown function, DUF399	Mifsud W	anon	COG3016	Family	No function is known for any member of this family.	27.70	27.70	27.90	27.70	27.40	27.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.51	0.70	-4.84	84	689	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	634	1	222	600	105	207.30	26	61.87	CHANGED	slshpplhtpltsscllllGEhH-ss..scHtlQhpllpsL......tp.....ps.phuluhEMhspcpQshl-pahsu..........phsppplhpthta.p.sWs...ashYpPllphAtppplPllAuNls+shs+plsctG...httlstt.ccthlss.ts..h.s...ssshcphh....tphh.....suH.tt..............................................................hsps...ht.................thhpsQ..thhDpsMApslhphh.........sttllllsGshHs...cpshGlPtpltc	................t.hohpplhtclt.s..AcVlllG..EhH..sps..tcHthQ.htllps...Lt........pp...............ph..phsluhEMhspspQshlD....ph.hps............plspp.pLhpth..h.p..s.....Ws........aptYpPllph.Ahppph..slluuN.ls+phl.pplhp.G....htth.........ppp...h...l.ss.hs......h.s...ssshcphh.t.hh.....tu.Hpts......................................................................................stp....hp.............phhtsQ..hhtDcsMAcsllpth..................tphllllAGshHs...ppshGlshplt........................................................................................................	0	76	146	189
+2069	PF04165	DUF401		Protein of unknown function (DUF401) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Members if this family are predicted to have 10 transmembrane  regions.	24.00	24.00	24.00	24.10	23.70	23.90	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.41	0.70	-5.45	4	109	2012-10-02 15:12:49	2003-04-07 12:59:11	7	2	97	0	54	238	36	372.40	24	97.56	CHANGED	slolLLh.FsVllVLIhl.KVNIGluIFlGuhhLAhLotLGlsGhLhoLh..us..pWsplhlIlIIuFlhGhopha..hGhLc+hppuhhclFs..KaShhhlPALIGLMPMPuGALlSAPMlcslspcaplsPEhtTllNYWFRHlWEh.WPhY.AlVlsSAllGlshtclSlphFPlsllhhhlGalFFstshccshpssRN....Lh..lhslYPIllllllSVlltLDhLhG.hluhLSl.l.NhhRlp.L+ElLcRsFp.+.IlhLLhAVMhaKsVIEsSGls-ulsthhlSaplPshllLhlhPhllGlhTGIohAYVuhshPLLpsFFou....hcplsLsYhuGYhGllhSPVHLClVhSAEYatsEltKlY++hLLPullhhllGhlhlhlI	................................................................h...hhhhh.hl.llhhh....h.h....+.+.ltl..u...h.uhh....hu.u.h..ll..shhh......h....s.h....pthh..h.shh....ss....phthlt.hl..l...h...l...hh.l..hshh.ph....Ghlcphhp..ulptlhsp...+hshs..h..hP..AhIGLLP.PGGAlhSAP.hVcp.ssp.ch.tlssc...cpshlNYWFRHlaEhhhPlYsulllsusls.s..lsltph.lhth.hPhs........lhhhlhG..a.l...hh.hp..........h...h.......pp........t.......t.....pt..ps...................................hh..hl..hs.hhPllssl....h........l.....s............l........h...h.............t...........l....s............h.h.........h...u..h.h...h.s.l...h....s....h..h.lht......hh.php.l.h.phl...ppuhp...h+....ll...hhl....h.hlhhFpphl.p....h...oG..sh....ptlsthhht.hs.lPh....hll..hhhls....FlhGlhTG....h....s.....uhl.ulshPl..lhsh..h..s.u.......hshh..s...lsahhuahGhhl.SPsH.l.CLllos-YFcschhplh+...h..l.h.hs.h.llhhh..hshh.....hhh........................................	0	28	44	48
+2070	PF04167	DUF402		Protein of unknown function (DUF402)	Kerrison ND, Finn RD	anon	COG2306	Family	Family member FomD is a predicted protein from a fosfomycin biosynthesis gene cluster in Streptomyces wedmorensis [1].  Its function is unknown.	21.50	21.50	22.10	21.50	21.30	19.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.26	0.72	-4.15	76	1865	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1388	4	316	897	10	69.90	40	36.02	CHANGED	hcttchhlphh..tsphaslthhh.cs.psphhshYlNlssssthppp....slchlDL.LDlh....l..hsss.....phpllDtDEh	..................................sc....csslsaFa..pc..haasl.....hsMh..cc.......s....slpY..YsNluo...Phhh.-cc............sl+alDa-LDlp.............V..hPsG.......chcLL.DtDEa.......	0	95	196	271
+2071	PF04168	Alpha-E	DUF403;	A predicted alpha-helical domain with a conserved ER motif.	Kerrison ND, Finn RD, Iyer LM, Abhiman S, Burroughs AM, Aravind L	anon	COG2307	Family	An uncharacterized alpha helical domain containing a highly  conserved ER motif and typically found as a tandem duplication.  Contextual analysis suggests that it functions in a distinct peptide  synthesis/modification system comprising of a transglutaminase,  a peptidase of the NTN-hydrolase superfamily, an active and inactive  circularly permuted ATP-grasp domains and a transglutaminase fused  N-terminal to a circularly permuted COOH-NH2 ligase domain [1].	19.00	19.00	19.30	19.30	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.91	0.70	-5.05	180	1295	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	831	0	486	1208	743	297.00	26	60.07	CHANGED	MLSRsA-sLaWhuRYlERAEssARllc.ssh......phshst.....ssss...ppht.slltssGstssattp...........t.thstpslhpalhh..DpssPuS..lhuslpsARpNA+tlRstlos-hWcslNphahplpphttpth..........................sppshh..phhchl.pppsthhpGhhpsoMhRs-uacFhplGphlERADpTuRlL-l+atsh.......................ss.h.-thpWpslL+usuuhpsYRphY.psshpstsls-hLlL-sphPRSltaslpplpppLppLt....tt..st...spspchhsp.lpspLphs.slcclh...................ttuLcpaLsphhpplsplustIsppYh	....................................hhSRsA-sLaWhuRYhERAEsh.ARllcssh.....phthts..........tsss.........ptht....sll....ts.hG..h...sshtpt...............h.......t...hs..tp.s..l...lphlhh......DtssPuSlhuslpsARpNA+slRstlos-hWcslN.s...hh..h..t.....l.pp.h.t.p.p.s.............................................ttt.shh....phhphl.tpps.thhpGhhtsohhRs-uapFhplGphlERu-t...ssRlLssphthh.........................................t..hcthtapslLcsssuhtsY+phY.p.s.t.hp...stsls-hLlLctphPRSlhaslpplpppLpp.L................t.thsstspchhsplt....s....pLphh..shpplh.........................ttsLpphLsph.tphtplustlsppah..................................................................	1	137	300	400
+2074	PF04175	DUF406		Protein of unknown function (DUF406) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Members of this family appear to be found only in gamma proteobacteria. The function of this protein family is undetermined. Solution of the structures of the two members of this family investigated bear some resemblance to that of the single domain enzyme pterin-4a-carbinolamine dehydratase, PDC. Although the residues of PCDs involved in binding of metabolite are not conserved in the two structures under study, they do correspond to a surface-region structurally aligned with residues that are highly conserved, eg Glu 89, suggesting that this region is also involved in binding of a ligand, thereby possibly constituting a catalytic site of a yet uncharacterised enzyme specific for gamma proteobacteria.	25.00	25.00	25.60	32.60	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.10	0.72	-3.52	51	1127	2009-11-21 14:42:31	2003-04-07 12:59:11	7	1	756	3	94	348	5	92.60	50	97.42	CHANGED	p.p..pps......-pCssCt..sssDlGslIDssDsshplshshsspttAcsthsphsp+A+ssp.....splpsplsss.-suhpLphsFsFpCpAEphIFQLphR	.............Mp...sss...DcsssC...CshDlGTlhDNsDCTupaSRhFAoRtEAEptLstLs.E+A+uVp..oEsspls.phs-..p.sGVcLDhcFTFuCpAEhlIFpLuLR.....	0	8	27	63
+2075	PF04174	CP_ATPgrasp_1	DUF407;	A circularly permuted ATPgrasp 	Kerrison ND, Finn RD,Iyer LM, Abhiman S, Burroughs AM, Aravind L	anon	COG2308	Family	An ATP-grasp family that is present both as catalytically active  and inactive versions. Contextual analysis suggests that  it functions in a distinct peptide synthesis/modification system  that additionally contains a transglutaminase, an NTN-hydrolase,  the Alpha-E domain, and a transglutaminase fused N-terminal to a  circularly permuted COOH-NH2 ligase. The inactive forms are often  fused N-terminal to the Alpha-E domain [1].	100.00	100.00	101.20	100.50	99.90	99.40	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.93	0.70	-5.82	28	1353	2012-10-10 13:17:03	2003-04-07 12:59:11	8	8	856	1	522	1302	873	327.40	42	53.87	CHANGED	PtlIsusEWstlEpGlhQRscsLsthLsDlYucpcllps....GllPsplVhusssatcthhGlpsPtshalHlhGhDlsRss-GpahVLEDNscsPSGluYsLENRphhpRhhPclapph.....plpslssahptLhcsLpshusss...sPp.lVlLTPGsaNusYF.......EHuaLA+phGl.LVEGcDLhlcDs+Vah+Th.pGhp.pVDVlYRRlDD.DaLDPLthpsDShLGVsGLhpAhRtGsVsls.NAhGoGls-DKulhsal.Pphhchh....LGEc.hLss..VsTahCsps.schcalLspLccLVlKsstssG.....GhuhllGsphop.tptphhpchhtts..salAQ	....................................PRlIsusEWppl-pGltQRlcALNtaLsDlY.s.....c.Q...........cIl+s....GllPscllhusst...a...h....t.....hh..Gl...p.....s...P........s.s..l.......a.....hHlsGhDLlR.s.s....-....G....p....ahVLEDNhRsPSGlS..YhLENRchhtR.haP-L...Fpph.........plps.l.s.s.Y....sptL........h.psL......ps..........h...............uP.................s..................s.....................ts...........Pp..lVlLTPG.haNS.A.YF.......EHuaLAcp.h......G......lpLVEGpDLhV.c.D.s.p.VahR.....Ts.pG..h.c..pVDVlYRRlDD.s..FLDPLsFR.s..DS..hL..GV...s...GLlpAhRuGsVslu.NAhGoGluDDKulYsal..PchlcaY......LG.....E.c....sl....LsN.....VsTahCtcs..sphpaVLspLs....c....LVlKssps..uG.........Ga..Gh..l.lGPp......soptphtpht.t.+.l.hspPt.saIAQ......................................	0	150	328	435
+2076	PF04181	RPAP2_Rtr1	DUF408; 	Rtr1/RPAP2 family	Wood V, Finn RD, Bateman A	anon	Pfam-B_22202 (release 7.3);	Family	This family includes the human RPAP2 (RNAP II associated polypeptide) protein and the yeast Rtr1 protein [1]. It has been suggested that this family of proteins are regulators of core RNA polymerase II function [1].	20.20	20.20	20.70	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.14	0.72	-3.89	45	383	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	326	0	228	335	3	76.20	28	20.32	CHANGED	hsphlo.spYc-llpER...sls.phCGYs.lCspshtph......pppaplssp............spplaphp..c.t..........................................paCSptChpt.StahpsQLsp	..........h...hhp.spYp.-llpER....sl..phCGYs.LCscshpp.....................+tpa+lstt..................ppplhshs..c..t.....................................................................................................................paCSptChcp.upahthQl.......................................................................	0	65	117	185
+2077	PF04188	Mannosyl_trans2	DUF409; 	Mannosyltransferase (PIG-V))	Wood V, Finn RD, Mistry J	anon	Pfam-B_9248 (release 7.3);	Family	This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface.  Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI [1] [2].	22.40	22.40	22.50	22.50	22.00	22.30	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.93	0.70	-5.57	4	631	2012-10-03 03:08:05	2003-04-07 12:59:11	8	10	512	0	342	606	30	277.80	20	72.07	CHANGED	Rpt..lhhatlhsRhlhLhLshLa..hhhshsputshssss......s.sthlsshhp+hLhs.hlpWDulaFlc..hucsG...aEppaAF.sLaPhhlplhs.phhsslhsLLultushh.shh.ls.hlhahlAshhLaplsp.lhpspchohhsullFChoPAulFhouhYSEuLaAhFoFsGlhph.pup........shsushhFuhush.hRSNGlhsssahshsthttha..uLhpLphshhhhphhsuhhLpshhlhlPFhh.QYYu.YppFC.st.........................s.sWCptplPL........lYsaIQchYWs...VGFLKYaphpplPNFLhAsPslIlllauhhhahp.........G.phsphppp.t.......................................................alVhsuhhlhhusFhMHVQVLsRhhS.uhPlhYWahAchlh.s.........Kpp.hpshu..............hthhhhWhs.............hYhlLtslLausFLP.s	........................................................hhh....................................................................................................................h.t.hhpWDs.aahp............lA..p....p.............G....Y..........................h...........t............t...........p........h...........A...F.......hP.hhP...hh.lp.......hh.......s..............................................h..........h......t.........................h.........h...s..h..h..l.s.....hh.........hhu..s...hhLapl...s.t...h......h.......................t.......t.........s......h.....h.............s.....sh.La.hh....sP.u.s.l.Fh.s.ssYoEu..............h......Fshhshhuhhhh..tsp................................................h.h.h.us.l...h....h....u...l..Ash..hR..ssGl...h.h...s...h...hhh.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	123	207	294
+2078	PF04190	DUF410		Protein of unknown function (DUF410) 	Wood V, Finn RD	anon	Pfam-B_12495 (release 7.3);	Family	This family of proteins is from Caenorhabditis elegans and has no known function. The protein has some GO references indicating that the protein has a positive regulation of growth rate and is involved in nematode larval development.	19.50	19.50	20.00	19.80	19.20	19.40	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.73	0.70	-4.84	5	337	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	275	7	236	317	2	239.10	26	79.21	CHANGED	sppK+a--AlELlasGAppFFcccQpuSAADLshhlLEsLEK..........AElssuspplssLAcllstLsPuEPE......RcshVsRslcWS.....osucGKaGcPsLHpllAppLlctcplppA++HFLLusDsSupAphhLlEYpps+spcuEs...DhFlucAVLQaLsLcNhsoAhsoFTpYTc+ahc..tPphEp.....hchsaPacpPLLNFLalLlhsl-sKcpusFpsLsppYpspLKRD.uapuYLs+IGpLYFGI+PspspSs..uLGGLhSuLLu	...........................................................................................................tpppaspAh-llhpGAhhhhpt.s..Q.....t..s....SuuDLu...h.hll.-shpp....................................sph..ps..s..pt.....h.....t.cLhp..lhphh.....s...sppsp............................+ppalppslpWS........................ph.u.p..h..ph.Gc..P..cLHphluphh.......h............c..............-...........p..............p.............h...........h...c........Ac..hHhlhu.........scsps...hs........hl.............ht.p.s...t.s....-s...............shahucAVL.aLhltN...hpsAptshptat..p....p.......t..t..ht..........................t......s...P...L...L....NFl.hLLh.s.lpp.....t....p.......h.........s...h....Fp..LpppYtsp...l...p..c..s.s..app.hLptIGphaFs..h.....sp.p.t..s.....hhshhushh...................................................................................................................	1	77	131	196
+2079	PF04214	DUF411		Protein of unknown function, DUF	Mifsud W	anon	COG3019	Family	The function of the members of this bacterial protein family is unknown. Some members may be involved in conferring cation resistance.	21.40	21.40	21.40	24.40	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.50	0.72	-4.47	109	858	2009-09-11 13:47:38	2003-04-07 12:59:11	8	4	685	0	253	667	461	70.00	47	46.02	CHANGED	pVpspsss..-hssl...KpchGlP.splsSCHTAll..s..GYslEGHVPAssIp+LLp-+.Pp.shGLAVPGMPhGS..PGM	.............t.Vpshpss..shssl...KpchGls.spLtSCHTAll.s...GYllEGHVPAssIc+L.Lpp+.....Pp..shGLAVPGMPhGS..PGM......	0	45	144	209
+2080	PF04217	DUF412		Protein of unknown function, DUF412	Mifsud W	anon	COG3092	Family	This family consists of bacterial uncharacterised proteins.	20.70	20.70	20.90	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.85	0.71	-4.38	21	797	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	793	0	92	296	13	139.50	64	94.36	CHANGED	shh.phlpcGQpYMKoWPhcKpLushFPEpRVl+AT+aAl+hMPslAllolshQhhh...shphhP.pAlshALFhlSLPlQGLaWLG+RupTPLPsoLhsWap-lppKLtptGhshpslpu+PsYp-LAplLKpAFcpLDcsah--	.....saF.olF+RGQHY.KTWPh...EKRLAPVFsENRVIKhTRaAIRFMPPlAVFTLsWQIAL.............GGQLGP...AVATALFALSLPMQGLWWLGKRSlTPLPPulLsWFYE....VRuKLpEuGQs..........L.A..PVEGK.PcYQuLADsLKRAFKQLDKTFLD.D..........................	1	8	29	62
+2081	PF04219	DUF413		Protein of unknown function, DUF	Mifsud W	anon	COG3085	Family	\N	25.00	25.00	32.30	32.10	24.00	22.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.09	0.72	-4.24	23	807	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	791	0	100	247	13	91.50	65	80.88	CHANGED	+FaDspNFPRGFuRSGDFTlpEAplLEpaGpshpuLtsGphpPpsc-EppFltsspGppssso.hE+sWhKYhchspp+p+FaoLsGst+..ss	........RaFDNKHYPRGFSRHGDFTIKEAQLLERHGaAFN-LDLGKREPVTEEEKhFVAVCRGEREPVT-tERVWSKYhTRI+RPKRFHTLSGGKP...Qs-...............	0	12	37	70
+2082	PF04220	YihI	DUF414;	Der GTPase activator (YihI)	Mifsud W	anon	COG3078	Family	YihI activates the GTPase activity of Der, a 50S ribosomal subunit stability factor [1].  The stimulation is specific to Der as YihI does not stimulate the GTPase activity of Era or ObgE. The interaction of YihI with Der requires only the C-terminal 78 amino acids of YihI [1]. A yihI deletion mutant is viable and shows a shorter lag period, but the same post-lag growth rate as a wild-type strain. yihI is expressed during the lag period. Overexpression of yihI inhibits cell growth and biogenesis of the 50S ribosomal subunit [1]. YihI is an unusual, highly hydrophilic protein with an uneven distribution of charged residues, resulting in an N-terminal region with high pI and a C-terminal region with low pI [1].	25.00	25.00	51.50	34.20	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-11.16	0.71	-4.92	30	794	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	788	0	94	348	14	164.80	55	94.86	CHANGED	RKusp.sssp...hssps++psRtpl-spuRpcK+cKK++GhcoGSRpstsptp..pp.psssppKDPRlGSKKPVsLhVpttstsp.........Php.....pps.............+LosEQELtpLENDtpLNpLLDpL-sGcsLussDQpaVDcpLDRI-pLMpcLGIp----s............ptps-DDLLcpFE	.....................tss.......tsK...utuKsR.RKTR-EL-tEAR-RK..R..pKK++GpAsGSRsuuGsss..usucs.Qst.KD..PRIGSKpPIPLs..VsE.psstp+.p.......PKs.......cKP.......................hLSPptEL-hLEsDERLDALL-RLEAGETLSAE-QuWVDsKLDRIDELMpcLGLohDDDE........E--..................E-EKQEDhhRL..h...................	0	10	31	64
+2083	PF04222	DUF416		Protein of unknown function (DUF416)	Mifsud W	anon	COG3068	Family	This is a bacterial protein family of unknown function.  Proteins in this family adopt an alpha helical structure.  Genome context analysis has suggested a high probability of a functional association with histidine kinases, which implicates proteins in this family to play a role in signalling (information from TOPSAN 2Q9R).	22.30	22.30	22.60	22.40	20.20	22.20	hmmbuild  --amino -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.98	0.71	-5.16	48	828	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	821	2	104	339	19	190.50	67	96.99	CHANGED	sshapRLcpLcsWQplsFhsuLCERMaPNYpLFs-hophu-.sphh+slLsLlWEhLssK.su.KlNF-pQLEKL.EphlPsss-.aDhYG...VYPAhDAChALusLLp........uhlstcsh.-cslplSplShsTVAsalE...spsscEls.--p.......lcppthhppEh-lQhplhchL..p-sppR.ch-lIcsL+p-lpps.GlSNIGIsl	.............................NPIHLRLE+LESWQHlTFMACLCERMYPNYAhFCpQTtFGD..upIYRRILDLIWETLTVK.DA.KVNFDSQLEK.h..EEAIPuADD.aDLYG...VYPAIDACVALSELlH........SRLSGETL..EHAl-VSKsSIoTVAMLEM..........TQAG..R.EMoDEE........LK-NPAVEpEWDIQ.WEIFRLL..AE.CEER.DIELIKGLRuDLREA.G.SNIGIt.h................	0	16	40	74
+2084	PF04224	DUF417		Protein of unknown function, DUF417	Mifsud W	anon	COG3059	Family	This family of uncharacterised proteins appears to be restricted to proteobacteria.	22.10	22.10	22.40	24.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.14	0.71	-4.90	6	870	2012-10-02 13:32:46	2003-04-07 12:59:11	7	2	767	0	99	439	11	168.40	46	92.16	CHANGED	h+hhchlshtschslsllRLulhIlFhWlGshKassaEA-uIpPhVuNSPahSahYch.p......................................ssYssS.hLGllEsIlulhlLlGhhpstsGllGGllshshslVTLSFLhTTP-sahst............P.LuGssphVlKDlLhlAuulhlhthstpchL	....................................hclluptsclGlsLlRl.uIsIVFhWIGhLKFssYEA-uIsPFVANSPhMSFhYca.t...p.h.pc..puE............................c.thtWpptNsTYuhSsuLGllElIlulLlLss...h..s.h..lGLlGGlhAhshslVTLSFLITTPE..sWVssLGss.............paGFPaL.S.G.A.GRLVLKDhlhLAGAlhlhu-uA+cl...............	0	23	57	78
+2085	PF04235	DUF418		Protein of unknown function (DUF418)	Kerrison ND, Finn RD	anon	COG2311	Family	Probable integral membrane protein.	20.80	20.80	21.00	21.00	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.94	0.71	-4.57	138	1711	2012-10-02 17:00:17	2003-04-07 12:59:11	7	6	1135	0	378	1373	248	158.90	28	41.74	CHANGED	hs+pshhp.tsppptphhpphhhhs..lslulshtlhhs.....................hhtshhhhhhthhuuhh.huhsYluhlhhlhpptth.ht.....h....hpslsssGRMALTNYlhQSllsshlF.huaGLGLhsplshh....thhhlslslahlQlhhSphWL+pF+hGPlEal....WRplTatp	........................................................................hh+pshhp..sp.p..hp...hh+..+hth..lh...lsluls.lsh.th..................h.h...s.ht.hss.hh.h....ph.......h.....p...luus...h.......huluY.suhh..hhhh.phpt..hp..............l.....ltsls.slGRMALTNYlhQ.........ollss..hl.F...................a.t.hu..L...hh...p.......h....s....hh....th.lhhslsl....ah.h.pllaSslWL.+.h.a.+.pGPlEWL....WRplThh.t......................................	2	131	275	337
+2086	PF04237	YjbR	DUF419;	YjbR	Anantharaman V, Kerrison ND, Finn RD	anon	COG2315	Family	YjbR has a CyaY-like fold [1]	25.20	25.20	25.40	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.31	0.72	-3.64	196	3031	2012-10-09 12:12:44	2003-04-07 12:59:11	8	8	2138	7	527	1873	137	96.50	28	68.23	CHANGED	shuhPsspcs..hsa........st....hsa+V...............u......KhFAh....hsttt............................lslK..sssppt.thLhpp..sshhsu..+hs+..pp.Wlsl.h...l......t.slspsplpchlccSapLl	...................................................shth..tsp.s...h.a.......s...ph...ssh+l..........ss..KhFAhltphptp.........................................hlsLK..s..s..P..-..hs..thLppp......ss.l.h.P.u.a..Hh.NK......pH.WloVh..........l........sssls.c.splhcLlscSaplh..........................	0	174	335	445
+2087	PF04238	DUF420		Protein of unknown function (DUF420)	Kerrison ND, Finn RD	anon	COG2322	Family	Predicted membrane protein with four transmembrane helices.	28.50	28.50	28.60	29.00	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.73	0.71	-4.21	60	636	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	597	0	165	381	289	133.90	42	79.22	CHANGED	lshLPhlsAslNuloslhLlhGhhhI..+ptphphH+phMlsAhshoslFLlhYlshphh.sssos......FG..............Gtu.........hl+s.lYahlLIoHIlLuslslPLsLholhhuhpp.................phspH+KluRhThPlWlYVulTGVlVYlMlh	.........l.sILPplsssh.sloslhlshGhhhI...........h.++plptH+shML..uAhshuLhFhlhYh..o.hp....hh......hssT.s.........FG...............Gsu..........I+h.hYh.hhLhh.HIhLAslsssLuLhsllhuaps..................phshHRKlu.ashsIWhhsulTGVh.VYLhl................	0	65	126	155
+2088	PF04239	DUF421		Protein of unknown function (DUF421)	Kerrison ND, Finn RD	anon	COG2323	Family	YDFR family	27.40	27.40	28.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.02	0.72	-4.48	196	3034	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	1816	4	627	2119	40	94.30	26	48.77	CHANGED	ccllpGcPhlllcsGclhpcsl..++p+lohs-LhttLR.pp.ul.hsls-VchAlLEssGplSVlh+s.p..tsht.....................................t.t.h.t.h.....................hpcl	..............chlcGcPsllIcsGclhhcpl..pptphots..-lhhpLR.pp..G.l...h.......pl....ppVchA.lLEsNGploVhhtt.c......h...............................................................................hhh....................................................	0	243	460	537
+2089	PF04240	DUF422		Protein of unknown function (DUF422)	Kerrison ND, Finn RD	anon	COG2324	Family	Predicted to be an integral membrane protein.	25.00	25.00	27.00	27.00	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.57	0.70	-4.93	13	245	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	225	0	128	250	252	208.50	23	75.40	CHANGED	uFs.hhsLhGlhsMthshlAuhl...phl.stRuhuhllshsuhuhulELLGspTGaPaGcatYsssLGPhluGhVPhslPluaFsLslsuYLLs..hshLu.csppphl+hhts....uhhlsshDlVLDPuhs..ulsFWsW.ssGsFa.GsPhQNaAGWlLoGs.luhslhsluashsulptchp....ssshhLsshVuhhhhhsslsLhhGhhlPstlulhLGluhl	...............................................................h..........hhhhhhhhhsshh....hph.G..h..tp...s.h.hh.hs..hsh....s.luhs...sEhlGl..p.TG..a........PFG.pYpY.s...s...s.L...G....pl.h.G.VPlhlsluW...hhlshsuahlu.............thhl....t............................t...t......t....h.h.p.hhhs...................uhhhsshDlhlDP.shs......sh.s.aW......h......W....p..s..............s.............G........s............aa....G...lPlpNahGWhlsuh....lh..h.hl..h.p.h..h....ht.h...t....t..h..................h..h................hh....hh.h............................................hh................................................................	0	43	103	124
+2090	PF04242	DUF424		Protein of unknown function (DUF424)	Kerrison ND, Finn RD	anon	COG2412	Family	This is a family of uncharacterised proteins.	25.00	25.00	27.10	34.40	24.90	18.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.59	0.72	-3.94	44	146	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	142	4	72	141	21	91.50	26	84.16	CHANGED	apsss..hhluhs-cchhGppapctp..hhlplscuFassphs...t.ppslptLpcs.........slsNlhGpcslshult.Ghhc.ssVhhlsuss+splspl	.......pspsp.hlluhCDc-llGcpaccsp..lhlplsct..FYsschs...p.-pshptLpcA.........slsNllGpcsVthAlchGhlc.ssVlhlsuss+AQlhph...	0	19	46	61
+2091	PF04248	DUF427		Domain of unknown function (DUF427)	Kerrison ND, Finn RD	anon	COG2343	Family	\N	20.70	20.70	22.80	20.70	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.09	0.72	-4.32	99	1160	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	605	5	492	1041	207	92.70	32	63.77	CHANGED	lpVhhsGtllA-opcslhlhE...sshsPsaYlP.pDlph.s....hLp..o.sppohCPaKGpAs.Yas.l.....ssts..tpsAAWsYsp.Phss.sstIpsalAF.as.stl	...............................hplhhsGtllA-..o..p..p...s.lhlhE...sshss.....h.......aY.lP.sD.lp.h.p..........h.Lp.t.o..sp.p..ohCPaKGpAs.Yas.l..hs...sspt..................hpsAAWsY.p.P.hst.....s.....tt.....I....tsalAFass...........................................	0	132	295	403
+2092	PF04250	DUF429		Protein of unknown function (DUF429)	Kerrison ND	anon	COG2410	Family	\N	20.20	20.20	20.30	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.54	0.70	-5.07	41	405	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	389	0	180	381	182	209.30	20	83.95	CHANGED	GlDhs....+suhlAlh..........ptsphhphthh..s.scllshhtst.....tllulDhPluL...............tss............tshRssDpthR+h..ht.....plF..Psp.shhtp.................................lotpuhplh..............tphthclhEsHPpsshptl.....ssstt.........t...tsh..RhthLtt.h....................th..shtpcDllDAhssAloAth.h.hpGps......hplsst.st...hspts	.......................................................GlDhu.....p.shlush..............tssph.h...thth...ht...s......tpllshhpsh...........shlulDuPlsl............st.................................................sutRss-pthpch......ht.........t.ssa.....sspt..shhsp..........................................................h.s.puhp.lt.........h.t....h...t........h...........t..ptstplh..EsaPc.su.h.h.sl.............ttt.t...............ctp....tps.h...t...t....hh....p...hLhphh................................h.....t..th.tp......htts-D....h.lDAhlsAh.sAhh...h.....s.h........h..............t................................................................................................	0	61	121	150
+2093	PF01861	DUF43		Protein of unknown function DUF43	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes archaebacterial proteins of unknown function.  All the members are 350-400 amino acids long.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.51	0.70	-5.39	6	163	2012-10-10 17:06:42	2003-04-07 12:59:11	11	3	152	1	80	301	87	239.00	33	61.06	CHANGED	-lLc+FpEIAK-RPcslppYDQGaVTPEoTluRVtLhasRGDLcGK-llVlG.DDDLTulAhuLTshPK+lsVlDIDERLIcFIc+sAcchGls.lEshsaDLRpPLPEchh++FDsFlTDPPETlhul+sFlGRGIusLKGtGsAGYFGlT++EuSlcKWtEIQRhLl.-hGsVITDlIcsFNhY.NWsYhppTRAhphlPlK+......cPEc.WYpSshaRIEsLc....s..+th-EElscsEclYpD-Euos	.........................................hhcchpplscsRP..pshtphD.QuhsTsETsltR.sh..l..h..tp+G.DLpGKcll.sl..G..DD.DLsS.......lA.l..u.......L...........o..........s.......h........s.....p........c....lsV..lDID.-RllcaI.pchAc...c...hsl.....s...lcsh..pa...DlRp.sLP.c...chh..sp..FDsFh...TDPP..........Tl....p...Gl.cLF..lu..R.G.l..p.sL.+.s.p...G...s......s.u...Yh....u.hoc.cc..s...o.hpcah..plQ.+hLl.chGl...llp-Il.sFNpY....shs...h...l.tp......hh.......h..h.p...................p..ahh....hhphh........................................................................................................................................	0	26	46	66
+2094	PF04254	DUF432		Protein of unknown function (DUF432)	Kerrison ND, Finn RD	anon	COG2430	Family	Archaeal protein of unknown function.	20.70	20.70	20.80	20.70	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.52	0.71	-4.20	17	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	63	0	53	71	5	120.30	27	51.26	CHANGED	hPlstst.thsphlhl+hcpPlllsPtsshphalchPl-luVhhsst..t..thlDhhshs..+tKYsLYGsspsGllsRYhcoplhsc.Pps......pulh+lhlpNpssphspls+lVFshhshphYY	...........Ph.h.t..hsphlhlchpcPlhlsPtsphphalphPl-luVhl.sst..................hlDhh..sls..+.KYsLYGs.s.....s.....sGsls..RYac..Sphhs.....p.Pcs....h...pulhcltlpNssschhpls+llhshhshplYY.....	0	19	33	41
+2095	PF04256	DUF434		Protein of unknown function (DUF434)	Kerrison ND	anon	COG2454	Family	\N	20.40	20.40	22.00	21.10	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.72	0.72	-4.59	19	102	2009-09-10 18:22:19	2003-04-07 12:59:11	7	1	102	0	64	100	2	57.20	35	25.61	CHANGED	tpLpcAhcDlpaLLNRGYs+csuLchVus+YpLstcpRhhLtRslho-c....cltt.h+pKh	.....hLpcAhpDlpaLLsRGYsc+suLphVuN+YpLspcpRhhLhRslhScp....plpt.h+pK........	0	27	40	53
+2096	PF04258	Peptidase_A22B	DUF435; 	Signal peptide peptidase	Bateman A, Studholme DJ	anon	Bateman A	Family	The members of this family are membrane proteins. In some proteins this region is found associated with Pfam:PF02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with Pfam:PF01080.	20.60	20.60	20.90	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.10	0.70	-4.97	14	885	2012-10-02 13:41:03	2003-04-07 12:59:11	8	15	291	2	585	836	37	274.40	29	63.39	CHANGED	pspppstshssptAhhaslsuoshLlhLahhachht..............................................................llhshFslsush.....................hahlhsshhph.p...............phsttphph.....................hphphshtplhshhhslslslh.alh+p..+..WlhpsllGluhslsslphl+LsshKsuslLLssLFhYDIFWVF........uosVMVsVApu.h-s........................PhhLhhPph............ssssaShLGlGDIllPGlhlAhshRaDh.t..................ptppps.YFhsohluYslGLllThluhplhc.pAQPALLYLVPssLhshlllAhh+s-L+phWs	.......................................................................................................................................................................................................................................................................t......phs..pA.hh.hslhuushLhh.L.ahh.hp.h............................................................................................................................................................................l.lhh.ha.hlhuhh................................u.hh.h..s.hh..........................................................................................t...tph.h...........................................h.php..h..sh..hpll..shhh.sh.hh..sl...h.....h....l...hpp...p.........W.l.hpshl....Gluhs..l..sh.........l....p.h..l+.L.......s.sh+s....us.lLLss..LFl.Y.D...l..Fa.VF.............sssV.MVpVApu..hcs...........................P..h..hL..h.hPp..............................sstsa.uh....LGlGDIl..l..P..GlhluhshR.a.Dh.h.................................................................................................tt.p.tps..YF..hssh.............lu..YhlGLlhThhs...h..t..lh...p.tu.Q...PALLYLVPssL.hs.hhhAhh...+s-lpthat..................................................................	0	194	304	452
+2097	PF04260	DUF436		Protein of unknown function (DUF436) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of bacterial proteins with undetermined function. 	25.00	25.00	30.10	30.00	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.83	0.71	-4.77	34	978	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	969	3	107	502	4	171.00	54	92.89	CHANGED	pphpphlpEllctusLcpGplhVlGCSTSEVhGt+IGpsuSh-lupslhpslhphhpcpGlaLAsQuCEHLNRALVVERpsAcphshEhVoVlPsh.+AGGuhustAacphp-PV.VEpI..pAcAGlDIGDThIGMHlKhVtVPlRsuh+pIGpAHVTshpoRPKLIGGsRAhY	....c.phppllc-lh-..pusLppG..slFVlGsSoSEVlGt+IGpsuShEluEhIhpslhplhc......ppGIpLAhQGCEHlNRALVVERplAp.p.hsh..E..lVoVlPsl.HAGGShtstAFctMpDPV.VEaI..pApA..GlDIGDThIGMHlKHVpVPlRssl+plGpAHVThhsSRPKLIGGsRAcY......	0	37	64	88
+2098	PF04266	ASCH	DUF437; 	ASCH domain	Kerrison ND, Finn RD	anon	COG2411	Domain	The ASCH domain adopts a beta-barrel fold similar to the Pfam:PF01472 domain [1].  It is thought to function as an RNA-binding domain during coactivation, RNA-processing and possibly during prokaryotic translation regulation [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.51	0.72	-3.65	85	2885	2012-10-02 17:37:24	2003-04-07 12:59:11	9	30	1955	15	561	1820	99	108.40	21	70.36	CHANGED	hp.........htsp.............htshllpGpKssp......hRhtspsh.....h.uphhll..hp................................spsphhshlclpsV...phh....papcl........spptuh.....-s..............sh..hhp.h.ph.....att............phhlss.p..Fchlt	.....................................thhpc.............htshll.sG.pKThT.............h.+..ps..-s..h.p.......h..Gph.hl.l..hp...........................................................................tp.sp.hs...hlclp.slphh.....phspl............stp...hAh.....tEs....................oLt...hp.ph.htch........a.t.................p..hhh.cat................................................................................................................	0	151	287	429
+2099	PF04282	DUF438		Family of unknown function (DUF438)	Kerrison ND	anon	COG2461	Family	\N	25.00	25.00	25.10	36.30	23.60	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.47	0.72	-4.18	27	563	2009-09-11 06:07:37	2003-04-07 12:59:11	8	11	557	0	100	390	1	72.00	48	16.66	CHANGED	hLKcllhcLHpGtss--lKccFppllsslsstEIshhEQpLlp.-G.lsscElp+LCDlHAslF+sulpphtp	.........lL+-ILhcLHsG..u.osEoVp-cFstpFsGVSAlEIShhE+ELMs...sG.lshEDVhcLCDVHAsLFKsAIcslc.s.......................	0	38	61	76
+2100	PF04283	CheF-arch	DUF439;	Chemotaxis signal transduction system protein F from archaea	Kerrison ND	anon	COG2469	Family	This is a family of proteins that are archaea-specific components of the bacterial-like chemotaxis signal transduction system of archaea. In H. salinarum, the CheF proteins interact with the chemotaxis proteins CheY, CheD and CheC2 as well as the flagella-accessory proteins FlaCE and FlaD, and are essential for any tactic response. CheF probably functions at the interface between the bacterial-like chemotaxis signal transduction system and the archaeal flagellar apparatus.	25.00	25.00	56.20	55.60	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.18	0.70	-5.14	14	80	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	50	0	56	83	0	221.30	22	74.64	CHANGED	ptltph.uphh.hspsshc..pspWpcucllLopcRlVlus.tptph....slslsplpDlssp.s.t........hsthpshsulphppc.....shllsssss.......t.ppFtphlFpsllstptVhlpcsAhhGGsV.p-upWE+Gplplsccslphshsstp..pIsl..............sslusl-tcp+plsGcp+.VLplcHscc.spslsoalh.ssp+p.hplLcthlp.pht..........-......phptth-	.................hlsch.Gphh..hsptshp..tscWpss+llLopcRlllss.pst+t....slslsplpDlsschs.pt......hhs.hsshsslphtps.....shllsstss........hppFtphlapslLs..tptlhlpaPAlhGGsV.p-spWEcGplplscpslph......shsssphhslsl..............sslssl-hpc+pl....sG.cc+sVLclc..Hhcs..sp..oV....soalt.sspcp.lplLpphlc.phh................c.............t...............................	0	7	33	47
+2101	PF04269	DUF440		Protein of unknown function, DUF440	Mifsud W	anon	COG3099	Family	This family consists of uncharacterised bacterial proteins.	21.50	21.50	23.30	58.30	20.80	17.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.30	0.72	-4.00	9	735	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	728	1	72	234	7	105.90	69	97.44	CHANGED	M...p.ho.D-sl-hAYDIFLEhAs-NL-PsDIhLFsLQFE-RGusEhs-suDcWpccVGhpl-s-taAEVhlGLss.Ep-Eh-DlFARhLlSRch-c+hsHllWKc	.MDLN.NRLTEDETLEQAYDIFLELAuDNLDPADllLFNLQFEERGGAELFDPAEDWQEHVDFDLN..PDFFAEVVIGLAD..oEcsEINDVFARlLLCREKDHKLCHIlW+E......	0	4	20	46
+2102	PF04284	DUF441		Protein of unknown function (DUF441)	Kerrison ND	anon	COG2707	Family	Predicted to be an integral membrane protein.	22.20	22.20	26.70	26.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.79	0.71	-4.30	35	1132	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1100	0	140	468	0	136.80	52	91.76	CHANGED	LhLllLlllGllu+NpSlsIAssVLLll+hhs.lsph.hPhlpp+GlshGlhllTlulLsPIAoGcIshcsLhpuhhShtuhlAlssGllVAhLuucGVsLlssp..PplssuLllGTIlGVuhhpGlsVGPLIAAGIshlll	...............LlLLsLhhLGhlu+NsolslulhVLlll+lTP.Ls..........sa............FPalE+pGlslGIlILTIGVhsPIASGpls.ssLlcSFhs..aKullAIulGlhVuWLuG+GVsLMusQ..PpllsGLLlGTlLGVAL..F+GVPVGPLIAAGlluLll......................	0	41	78	108
+2103	PF04273	DUF442		Putative phosphatase (DUF442)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	Although this domain is uncharacterised it seems likely that it performs a phosphatase function.	24.60	24.60	24.60	24.90	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.29	0.72	-4.20	5	718	2012-10-02 20:12:17	2003-04-07 12:59:11	8	8	547	8	211	636	313	108.40	33	46.58	CHANGED	-hRclo-cLSVSPQlss-DlAshAcpGF+olINNRPDGEEPuQPuNAAlpAAAcAAGLuYsalPVhsGsITs-sVcuFpcAlAsA-GPVLAaCRSGTRulsLYALuQAlc	.....................................hplscphslu.s.Ql.sssDl.t.p.l.u.p.tGa+olIsN.R.PDsE.t.s.s.QP.s.h.tp.l.pps.AcptGl.s.a.h.alP.V.s..u..s.p.l.o.p.p.sV.......ppF.t...ph.ls..p...h..t..t...P.VLA.aCRoGs.Ru...ss...Lasltp...t.......................	0	62	127	168
+2104	PF04276	DUF443		Protein of unknown function (DUF443) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of uncharacterised proteins.	26.20	26.20	26.40	26.40	26.10	25.80	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.36	0.71	-4.88	22	1105	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	227	0	32	406	0	179.30	47	93.80	CHANGED	Ns+YRIlchssEYhhlDl.ssoahshhFPhlsWllP+chhKIopcEh.EpLphs+ss.........Kspsh.hsshGu...ulLlushlRthhphhslphpphlshhlshlshlhllhhalhls++h+hplas.s....ppscpKlhlhP.ohKphhhhlFsYlhhhuholhslhhhl..pspNlIhalshhhhh.hhhhhlNhhoIss.ppspVhh+	.............................................NPKYRlI+YssEYLMlDl..lS.oWlshFhPhINWhIPK+YsKIS..ccEa..EsL...Nl...VKPs.........KspsF.....WPlsGu......ol.LhulhhR....K..Yhhlh...slpL.-Kp.lVIhlChlshlG...ll..hFalhLN+K.LpLplas.s....+spppKl..l..LlP..ohKsh..shh.lFsY.l..hhGuhShhhl.hLlohs.QNIIlalsW.lhhh.hhF.FhlNhssIhs.Kpl+Vlh.................................	0	13	24	31
+2105	PF04285	DUF444		Protein of unknown function (DUF444)	Kerrison ND	anon	COG2718	Family	Bacterial protein of unknown function.  One family member (Swiss:Q97LI1) is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA).	20.30	20.30	20.40	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.35	0.70	-5.84	8	1564	2012-10-10 16:07:06	2003-04-07 12:59:11	7	3	1281	0	389	1028	179	338.70	43	98.30	CHANGED	MuhFlDRclNs..+cKohssRQRah++h+.EpIKculsDtVsc.cSIsshsutEslpIPtRulcEsph+.Gc.sGcpc+VtsGsc.....c.psGDhIsRssuGsG.tGsGcGpuuuDsEG.......EDtFphplSp-Ehh-lLFEDLpLPNLp++phsplsp.h+sc+AG.hpssGlsuNIshsRTlpsuluRctuhs+upp..hcu..tpl...t...s.tlhct.......tht.hcs+hcRlP.lcs.DLRa+paccpPcPpSpAVhhClMDVSGSMspscK-lA+RFFhlLphFLpp+YEsVElVFIpHHTpA+EVsEc-FFappEoGGTIlSSAL+hhpElIcERYssAcWNIYuhpASDGDNas-DosRClclLppclhthsphauYsEIs....hpsHps.........hhcYcthpsshDs.FthppI+stsDlaPVh+plFp+Eps	................................................................................t.hIDRR.Ns..+sKShsNRQRFl+Rh+.tpIKpuls-tlsc.cSl....hsh....p....s....s..-p.lsIPh..cslsEP...h...F...+p...Gp.sGhp.c.pV.tP..GNs................cahpsDpltR..PtuGu...............u....GsGpGpu.u.t-.GEG.......pD...pF.FplSp-Eah-hhFEDLtLPNLpppp..pp.lsp.h+.s.cRuG.hpssGs..Pu..NIslhRolpsuluRRhAhsts..t.hpth..........tt.l......h.......t....................t.....t................h..t..l..t..l.ct+htp...lP.aIDshDLRa+sapcpPp.Ps.SpAVMFClMDVSGSMsptpK-hAKRFahLLYlFLpR..pYc.s.V-lVaIRHH.TpA.KEV.s...E.c-.FFau.....pEoGGTlVSSAL+LhpEllc...........pR.YssspW.NIYuAQASDGDNW.s.s.Dosh.CtclLtpcllshspaauYlEls.........ptHps...........WhpYpplp.t.t.h.ss..FuhpplcptpDIaPlFR-LFp+p..u..........................................	0	133	240	315
+2106	PF04286	DUF445		Protein of unknown function (DUF445)	Kerrison ND	anon	COG2733	Family	Predicted to be a membrane protein.	33.80	33.80	33.90	33.80	33.60	33.70	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.28	0.70	-4.93	106	2067	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1694	0	414	1545	89	326.60	24	87.11	CHANGED	sEAAhVGulADWFAVsALFR+P.....lG.l.IP.....HTulIP+p+-clucsLuphVtsphLsscs...ltp+lpphshsptlspaLt..........ps.....spsptl........................sptss.phltthlctlpcpclpphlcptht...............................................pplpph.hushhuplLp.hht-scpptlhDhll......pphtphlpsscsp..ltphlpchhpph.sthh.....................stplsptlhpth.phlcclpt-sp+.hRpphsptltphlscLtps.th..pch-plKpphlsc.thpphhps...lhpplcphlhpthps.s........hlcpplsphhtthsp.........................................pLtp-..splpppls........................chlpptsttllsp.ttplspllp-slcpa-scclpctIEhtlG+DLQaIRlNGollGGllGlll.aslshll	....................................................h.uuhlGulssWhAlphLF..R...P..........h.h....h.lP........p.s..........ulIP+p+-clucsluphVpcchLssps...lhtt....l........cpt..p....sthltphhp............................p...ptsppl.................................................................stphh.phhpt..h..lph.h...t..s...t..p.....lpp.hlpp..t.hp......................................................................................................................................ptlpp..h.hs.t.h.shh.......ppphp..hh-h...lh..............tphh.t.h.ltp.pp.sp..ltp.l.ph.h.pp..sh......................................tthsphh.pt.......phhs.cl.....pt..c........t..+..h.c.....p.t.hs.p.h.h....hl.pp.Lh.p..............tchc.thKphhh.p.c.....t..h.tphhtp....................lhtp.l..pphl.h.s.thsp.p.................hhpp..ltp.hht.h.hp...........................................................................................................................plhtc......stlttplp....................................................................thlpptstplh.p.........h...l..sphlp-pl..psa.Dscchpc.Ip..hs+-LphIch.GsllGuhIGlh.hhls.h..................................................................................................................................................................................................................................................................................................................................................	0	158	296	367
+2107	PF04287	DUF446		tRNA pseudouridine synthase C	Mifsud W	anon	COG3098	Family	This family is suggested to be the catalytic domain of tRNA pseudouridine synthase C by association. The structure has been solved for one member, as PDB:2HGK, which by inference is designated in this way.	25.00	25.00	25.80	25.70	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.97	0.72	-10.29	0.72	-4.20	56	892	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	888	1	128	441	33	100.00	49	91.89	CHANGED	cp.p.ltptLtpLEttL+phsLWpspsPsscAhsSspPFulDThshppWLQalFlPRMptLl-sstPL.PpphulsPhhEcshp..pp...sphptLlshLpplDpLl	..........c.spV+.pLpsLEshLRcpphW..ps...st..Ppsct....FsSspPF.hhDTMcPhEWLQWVhIPRM+sLL-sspPL.PsuFAlAPYaEh..ALs....-+...Pppth..l..L..A.LpcLDsLh......................	0	20	49	93
+2108	PF04289	DUF447		Protein of unknown function (DUF447)	Kerrison ND, Finn RD	anon	COG2457	Family	Archaeal protein of unknown function.	24.80	24.80	25.20	24.80	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.99	0.71	-4.71	45	190	2012-10-02 11:35:36	2003-04-07 12:59:11	7	1	185	12	120	206	54	176.30	24	88.66	CHANGED	hEsllTTtssp....NhAPlGllh...cucs....hhl+lFcsS+ThcNltpsshhslslssDshlaspsshsth..p.tht.sh......h....hLcsuhsahthclpph..........pssspthhhphpslctthtp.....sh...NRupsullEusVhsTRl...ph.....hptcclhpclphhttllcKsGGspE..pcAhchlpc	............................................EsllTThs.p.....phAPlGlhh...................pssp.........lhlphacsopThcNltp..pshsslshs.sDshlFstushs....tthp..h......th...........hLpsuhuahph...clpph..........psssp.h.hhphcslctthpp.....htsa...NRApsAVlEusVhsoRLph........hst-clhpcltahtts.lcKsuGtpE..pc.Ahphl..t.............................................	0	30	74	101
+2109	PF04296	DUF448		Protein of unknown function (DUF448)	Kerrison ND	anon	COG2740	Family	\N	21.60	21.60	21.60	22.70	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.83	0.72	-4.35	155	2403	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	2395	1	477	1345	326	77.80	31	69.80	CHANGED	.RpClsspc.hts+ppLlRlVhss-....u....p.lshD...pt+hsGRGAYl.ssstp..slcpAh.....++..+thsRuh+..ss.............ls..ss..lhct...lpphl	.............RpClsspc.h......tsK..+-LlRlV..t..s.p-...G.......................p..lhhD...soGKtsGRGAYl.shc.....p.slppAt.......++.......+shs+uhchp............lscp....hhcpL.t..h..............................	0	172	342	420
+2110	PF01863	DUF45		Protein of unknown function DUF45	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This protein has no known function.  Members are found in some archaebacteria, as well as Helicobacter pylori.  The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved histidines.  This motif is similar to that found in Zinc proteases, suggesting that this family may also be proteases.	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.57	0.71	-4.53	82	3481	2012-10-03 04:41:15	2003-04-07 12:59:11	12	7	2755	0	820	2754	698	165.60	22	80.80	CHANGED	+plplplps.ssl.plssPhthsppplpphlpc.....+tsWltpphtchpp............tthhsspth.h..hGcpapLphhtsp.....................hhh.thp.pthpptlpcah+cpspt.hlppt....ltthspthsl...ph.tphpl+sh+oR.WGSC..ss...psplplshcLlhhP.pll-YVllHELsHLh.chNHutcFWpllsphhPs.acct+phLcpt	..................................................................................................................................................................................................................................................................................................................................................t.h......th.h..t.h.t......h..h......h.....h...............h....t...h...................ht.....l.p...p...pp.p..WGoC....pu......c....s.....pIpl...s..h.t.l..h..t....s.P...hl-Y.....ll...lHELsHLt...c..h....s.........HsctFaplspphh.P.p..a+p.hct.Lp......................................	1	265	553	699
+2111	PF04313	HSDR_N	DUF450; 	Type I restriction enzyme R protein N terminus (HSDR_N)	Kerrison ND, Finn RD, Yeats C	anon	COG2810	Family	This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA [1]. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA [2].	21.10	20.50	21.10	20.50	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.44	0.71	-4.56	77	3819	2012-10-11 20:44:43	2003-04-07 12:59:11	9	43	2584	8	831	3899	642	175.90	19	18.43	CHANGED	thsEpthcp...hl..hl...hGaph.................ht................................................................................................................................................................................+sDlslhlN.......................GlPlsllEhKp..................................t.pt......hppLapYs...........................................thhlhoNGpphthhsthsptpp	.......................................................................................................................................E..h.t...h...h.....t......s.at................................................tt....h..t....h.h..t.h.t.p................................................tt.......................t......t..h..h....t....h..h.......t.....h.......................t.......h...h.............hs.h...p..p......t..p................................................................................................Np....h....p..l..spphphp................................sp.ppp+.hDlll.h.l..N.......................G.l.Pls...hlElKp..................s...sl.ppAh.p.......Q..hp.p.Yp.pp...................hppl.a.pah....................................................tlhhh.os.shp.shhhst.t....p..............................................................	2	293	576	721
+2113	PF04301	DUF452		Protein of unknown function (DUF452)	Kerrison ND	anon	COG2830	Family	\N	19.50	19.50	23.70	23.10	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.33	0.70	-5.04	2	358	2012-10-03 11:45:05	2003-04-07 12:59:11	8	2	355	0	43	228	1	204.30	37	95.06	CHANGED	McTpahspQGspLIlYFAGWGTPPssVpHLILPENaDLhlCYDYpDLphDhDFSAYpHIRlVAWSMGVWsAERshQGh.LhSATAlNGTGLPCDDpaGIPpslFtGTLpsLsEssRhKFERRhCGsKs.hcDYQpashRP.htEIHtELhALashltQDRRTDLIpWopAlVGStDKIF.stNQ+tYWpsRCslpEIsstHhLFs+FTHWpsh	.................................p.p.p..u..p.c.LIlhFuGWuoss.shhs...HL..h.......s.....p......s.....+..-l.l.l.s.YDYcsLs.h.......c....F....D........h..s.....u...a...p..c.IpLlAaSMGV.....as.A....sR..l.L..........p..p....l.....p.......h...p..p..t..h....A.....INGTshP.hD.cphGIssuIFctTLcs.hstp...sht+Fc+pht.t-.+p..h.pca.p.ph.s.t.+s.hc-l+pELptL...a.t.h...ht.p..c.....p..p...p..s......h.l.h..W..spsh........luppDcIFPsss..+pha.p..p...h...h......l.....l..-.t.sHahF.+FppWp............................	0	13	26	37
+2114	PF04303	PrpF	DUF453;	PrpF protein	Kerrison ND, Bateman A	anon	COG2828	Family	PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerise trans-aconitate to cis-aconitate [1].	20.20	20.20	20.80	20.80	19.30	20.10	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.34	0.70	-5.72	6	1338	2012-10-03 03:02:41	2003-04-07 12:59:11	8	10	1077	9	378	1097	393	341.90	45	96.08	CHANGED	.l+IPsThMRGGTSKGVFF+hp-LPtss....stRDtlLLcVhGSPDPh..QIDGhGGGsSsTSKVsIlutSSpPstDVDYLFGQVuI-cthVDaoGNCGNlSAAVGPFAIcAGLV.sA+hP...lstVRIapsNhuKhIlAcVPlssGpVp.sG-hplDGVshsuA.ltLsFhDsAssss..GtlFPTGN.lDsL-sst.G.lpsThIssuhPhlhV-A-ulGhsGTELtEElNuD.phLA+hEpLRshuAh+MGhluclc-ts.p.tTPKlAhVusPppYhsSuGthhtus-IDlhVRhhSMt+hH+AhhsTuAVAIuoAsAl.GTlsshhAGust.hssVphuHPSGsLcVtscscp.pt..sh.pAthsRoARhLMEGaVhlP	..................................h+IPsshMRGGTS+GsFhhhpD...L...Pp.st....stRDtlLhtlh...GS..P.......D..sh......QIDGhGGuss.TSKssIlS............+.....................S.s...............c........s..c.....tDV.............DYLFuQVslc.c.sh.VDhosNCGN.h.uu..VGsFAIcsGLl...sup.P....................lspV....RIhpsNh.GphI.AcV..h.........s.....s...G....t..........V....p.......p.....G-.h...clDGVsh.s.AA.VtLpF.lss...Ausps.......Gp......hFPTGN...hl.D.l.......-......s......................................l..psThIssuhPslhlsAps..L......G..h......o.........G.h........E...L.........s...p.ls..uD.tt.hLu....+....hEsIR..htuuhtM......G.lsc......l......s.p.h.s.........hPKhshlus..s...p.....p.uG.........sls..VRh...h....tphH+AhhhTu..AlAIuo.........A....ssl..GT.ls.p.......h...................s.................s.........u.......s...............s.........h..............s....s..................lphtHPSG..sLcVt..hp...s..c...t..tsu........ssh+A..sh.RoARhlhcG.VhlP...........................................	0	82	190	304
+2115	PF04304	DUF454		Protein of unknown function (DUF454)	Kerrison ND	anon	COG2832	Family	Predicted membrane protein.	21.60	21.60	21.80	21.80	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.41	0.72	-3.95	112	2157	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	2047	0	323	1155	310	69.50	27	54.83	CHANGED	hapWLlsH.haGshlcsWpppculsh+uKhhAlhhhhhshshu.hhhssh.hasphhlhshhh.hlthalhph	...FasWLltpphaGs.al...csapc.p.+.uhshpsKhpullhhhlshulS.....la...hs...sh....hhl.+l...hLhllhh..hlhhahap...............	1	79	164	253
+2116	PF04305	DUF455		Protein of unknown function (DUF455)	Kerrison ND	anon	COG2833	Family	\N	25.60	25.60	25.70	27.00	25.00	24.70	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.50	0.70	-5.11	81	772	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	692	0	260	668	146	239.50	38	83.29	CHANGED	LtssDspcKsthspphtpta..tp.tph........shh..sth.........s......tPuRPtcPpLlsPpc..l.s+R.phso.cGRhslLHAlAH..IEhsAI-LAhDhlhRF....................................tsh.....Pps.......FapDWlcVAs-EAcHFsLLpp+L.pplGtpYGDhPAHsGLWcsuccTspDlhuRhAlVPhsLEARGLDsoPhhhp+lppsGDp....pusplL-lIhcDEIsH...................VuhGs+WF+alCp..pcsh-.........Phps..ap.pLl..ppahtstl+sPFNtcARtpAGhsps.ht.	...............................................................................pss.ppKsthspphht.thtstp.hth................t......th..........t....hPuRP..t..p..sp.Llt.Ppp...l....+R.phso.cup.ssllHAlAH..IEhNA..IsL.ALDsshRF.........................pshPtp.......FatDWlcVAs-Eu+HFpLLps+..L..ppLG............h..cYGDhP...........uH..su......L...........Wph...sp..pTtpDlhsRhAlVPpsLEARGLDssPhlhtKlppsGDp.....tssslL.-...lIhpDElsH...................VuhGs+W.a+alCp........pp.th.-...........................Ph..th....FppLl...pth.h..h..shh..+s...Ph..NhpARtpAGFspp.hp.s........................................................................	0	81	174	222
+2117	PF04306	DUF456		Protein of unknown function (DUF456)	Kerrison ND	anon	COG2839	Family	This family is a putative membrane protein that contains glycine zipper motifs [1].	27.60	27.60	27.60	31.00	27.30	27.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.90	0.71	-4.15	85	842	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	833	0	221	624	147	138.90	30	85.95	CHANGED	hllPlLPGs.lllasGhllasas.suhs....huhhhlslhsllsl.lshlhDalssshGs++hGuo+huhh....GuslGsllGhFlhs...Ph.......Gll....lGPhlGAhluEl.hppc.........s...h......ppAh+suhGuhlGhlsussh+hslslhhlshFlhsl.h	..............lhPllPGs.hllasGhllatas.....hsht....huhshhlshsllsl.lhhssDalusthts++hGuSKhu.h....uuhlGsllGhFhhP....Ph............Gll....lsPFlus....als....EL...lptp..........sh......ppAh+sulGoll.GhlsuolschhlthhhlhhFhhsh.h.....	0	75	163	208
+2118	PF04307	DUF457		Predicted membrane-bound metal-dependent hydrolase (DUF457)	Waterfield DI, Finn RD, Bateman A	anon	COG1988	Domain	Family of predicted membrane-bound metal-dependent hydrolases, based on Swiss:Q97LP7. May act as phospholipases.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.30	0.71	-4.89	181	3256	2012-10-01 21:01:47	2003-04-07 12:59:11	9	8	1920	0	845	2084	420	171.40	23	77.02	CHANGED	shoH.h.....hhGhsluhsh.ht................................htshhhhhhusluuhl...PD.lDhh.........thh.sptht.h............................................................................................HR.uh.THSllhhhlhuh......................................................lhhhhhthh........................hhhhhhhhhlGh...hsHllh.Dh..hTs.....h.Gst...lhaPh...................pptphths...hhhhhss........hhth...............................................................................................hhhhhhlshthhhtthh	............................................................................................................................oH.h.....hhuls.huhhh.h.t..h..................................ht.hthhh.sul.lsu.hL.......PD..lDph...............shh..spththl..t...................................................................................................................................H.R...G.....h.TH..S........l.l..hs.hll..sh.....................................................................................lhhhhhhth...................................h...hph.h.h.h.h.h.luh....loHllh.Dh.....hTs........h..G...lt........hLaPh..................................phph.ths.........hhh..h.hss...........hth...........................................................................................hh...............hhhhh.......................................................................................................................................................	0	248	566	724
+2119	PF04308	DUF458		Protein of unknown function (DUF458) 	Waterfield DI, Finn RD	anon	COG1978	Family	Family of uncharacterised eubacterial proteins.	25.00	25.00	26.50	67.80	22.10	18.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.64	0.71	-4.47	19	224	2012-10-03 01:22:09	2003-04-07 12:59:11	7	1	219	0	67	155	174	148.90	44	90.53	CHANGED	ccshpcIhpaltpsspssY+lhlGTDSQst.spTpFVTAIllHR....hGKGA.taaappphp++lpS....LRQ+IahETshSlElA........scltchltttsh...tshslElHlDIGt..pGcT+-LIpElVGhlhG..GapscIKP-SYuASslAD+aTK	...............p..VhpcIpsFlcc.D.PcshY..+LsIGTDSQs+..pc..sTcFlTAIhIHR....lGKGA.thha+pphpc+.to....LREKIahETphS.ElA.........pplh-lLt.hst....sshhhEIHLDIGs.....cGhTK-hIp-hsuhIpu....MG.hpAKIKPDuYAA.ShANRaTK..	0	42	56	61
+2120	PF04311	DUF459		Protein of unknown function (DUF459)	Kerrison ND	anon	COG2845	Family	Putative periplasmic protein.	20.20	20.20	22.20	21.30	18.50	19.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.94	0.70	-5.59	2	172	2012-10-02 11:02:24	2003-04-07 12:59:11	8	2	171	0	55	291	5	282.60	32	67.88	CHANGED	Psl.Ip+tps..h.ht.h.Phh.st.QhsIsphhP.hR.shl..sG.h.tstht-s..hs.thu.pPAstlstpssus..hlp-shhs.P.tlt.s...sE+.sssss.hhupsshp.hhsGDsp.p.hotshhp.htpp....thtItpspVs..hhshs.ha+hP+hh.shLshps....hAA..huhthsDh.s.FhDtsGuhssstssh.tpshc.+hcsslNl.ht.ph.hsahhthP.h+.htLst.hshh.tst.t...V.A.hssttshhhs..h..llsssthshuotlhssts.hhts.thsG.+hsIEGt...h.ph.PhhhsDhphs	.............................................................t.t.tspsssss............................................t..t.sss...+hhll...hGDhhustlu-G...L..ptsaspsPs...lhl..s.p..ssuso....GhVR...cDhh...sWsttl.......hhtt.....pp.ss.....lll....hlG...uN...D.RQ..shhs...s..s.s..p.......hpsp.ospWpp.p.Yp+Rltths.chl...s...cp...+...hP...l....lWVGhP...sF+sp..th.op..D..h.Lsh.N.pl.YRsuA..p.+s.Gu.pasDlWD.GF....VD..EpG.p..F.s.po.GsDhsGQpsRLRusDGls.hTps....G+RK..LA..aYsE+Pl....pchL.u.h.....s...tp.ht....l..sssp..............ph.s...spsh.hs....ss...L..ts.stc..u..s...Lh.G....s.s.st.........t..h..ps......ctp...........hhhtDh........................................................................................	0	13	27	35
+2121	PF01864	DUF46		Putative integral membrane protein DUF46	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein has no known function. It contains several predicted transmembrane regions, suggesting it is an integral membrane protein.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.22	0.71	-4.39	4	235	2012-10-02 14:06:56	2003-04-07 12:59:11	12	3	221	0	122	719	285	165.20	30	94.67	CHANGED	hhsll..LtslWalLPAYhANsSullhGGGTPlDhGKsahDGRRllGDGhTWRGhhuGlhsGsllGllQhhL............Golh.tlhLuFLLuhGAlhGDhsGSFIKRRLsh-RGpPAslLDQLsFlluALhhu..YP..ltslPh-hIlllhlITshlHhuuNIIAY+LGhK-V.W	..................................................hh.............hhPshhsNsss.h.l....h.......u........u.......tpPlDh.G+ph..........h.DG+..R..l....h...Gs...uKTa+Ghhs....ul....hh.Gs.lhu..h....l...s....h...l.....................................................................s...h.h...........l.hhu..hh..luhu.AhlG......DlhuSFlKRRlsl...p........c....G....t..................s................h...l....DQl.D.h.l.l.u.u....l..lhh......hh...........h..h.s..l..s....h.t...........h..lh.l..ll.ls..shl..HhssNhluYhltlKp..a..........................................	1	34	75	100
+2122	PF04312	DUF460		Protein of unknown function (DUF460)	Kerrison ND, Finn RD	anon	COG2433	Family	Archaeal protein of unknown function.	24.30	24.30	24.50	89.00	23.30	24.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.45	0.71	-4.65	30	115	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	115	0	80	116	4	136.10	41	22.10	CHANGED	+sh+utDVpVclcshh+c+lcFhsh.......st+.cchlIVGlDPGhoTGlAllsL-GclltlhSpRshspu-llchlhphG+PllVATDVsPsP-sVcKlupshsAsLYsPpccLol-EKtcLscchu.......phcssHERDALAAA	................p..h+utDVpVclcsh.ccplcFhsh.........tt+.+chlIVGlDPGhTsGlAllDLcGclltlhSpRshspu-llchI.chG+PllVAoDVsPs.PcsVcKlupsFsAhlasPccsLsl-EKpclscchu........hcssHpRDALAAA.	0	21	50	65
+2123	PF04314	DUF461		Protein of unknown function (DUF461)	Kerrison ND	anon	COG2847	Family	Putative membrane or periplasmic protein.	22.20	22.20	23.30	22.30	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.19	0.72	-4.40	175	1433	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1205	6	437	1186	538	110.60	30	62.80	CHANGED	lpcuasRs...............sss..ss.............................p......suAua.hslpNpuspss.pLluss.os.sAppsElHpphh.c...sGhMpMpplp.slslPAssslpL.....pPG....G.hHlMLhsLpps.l.ptG-plslTLpF..ccu......sp....lplp	..................................................................lpssasRs.....ss.s..st..............................................t......suuua..hslp..N.pu.........s.pss.pLluss..o.......s..susp..sElHphhh..p..........susM.+Mppls...slslPAss.slpL.....cPG.......G..hHlMLhsLcps..l.ptG-plslTL..pF..csu....tplpl.......................	0	102	259	351
+2124	PF04315	DUF462		Protein of unknown function, DUF462	Mifsud W	anon	COG3101	Family	This family consists of bacterial proteins of uncharacterised function.	21.00	21.00	22.20	21.60	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.10	0.71	-4.87	44	863	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	858	0	104	403	45	164.50	66	89.42	CHANGED	lFNpsFtppaNTpLVpGs-EPlYlPA.......ssp.......sap+IlFAHGaauSALHEIAHWClAGpcRRhL.DaGYWYpPDGRstppQspFEpVElKPQAlEWlhuhAAGhpFpVSsDNLsGs.psD....ppsFpppVtpQlhpal..p....................pG.lPtRAttFhcALppaYpss..ls.ppF.ht	.............IFNsCFu-.-FNTRLlKGDDEPIYLPA.......Dsc......VPYpRIVF.AHGFYASAlHEISHWCIAGcsRRcLVDFGYWYCPDGRDAQTQopFEcVEVKPQAl-WLFCVAAGaPFNVSCDNL-GD.hEPD...........RlsFQR+VHAQVhsYL....p....................pG..IPcRPA+FI+ALQsaYcTP.pLsAEpFs.hs...........................	0	22	47	79
+2125	PF04317	DUF463		YcjX-like family, DUF463	Mifsud W	anon	COG3106	Family	These proteins possess a P-loop motif.	25.00	25.00	26.90	26.90	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.57	0.70	-5.91	51	1031	2012-10-05 12:31:08	2003-04-07 12:59:11	7	2	996	0	159	638	61	429.50	59	95.04	CHANGED	lRLuVTGLSRuGKTsFITuLVspLLcs............u+LPlapusppGRlhuschtPQPD.sVPRFsYEstlsuLhsss..PpWPsSTRslSELRLul+Ypspsultphhss.uTLaLDIVDYPGEWLLDLPLLcpsatpWSppphshhps.tRtplApsaLsthpslD.sutsD..EtphpplAcsaTsYLpss+tpp.GhphlpPGRFLLPG-.LcGuPsLsFhPLsh.s........ppsscsShhshhc+RY-tY+ppVVKPFa+-HFuRhDRQlVLVDsLsALNtG.pAhpDhcpALsplhpuF+hG+s................ohLscLF.uPRIDKlLFAATKADHlpc-QHspLhuLlppL...lpcutppApFpGscscshAlAulRATppuhVppsGcplsslpGp.hts..........scpsslaPG-lPpch................sssshWppts.FpFhpFpPstl......ssstslPHIRLD+sLpFLLGD+L	.......LRLAVTGLSRSGKTAFITuhVNQLLshps.........s.......uRLPLhu...As...REpRLLG.....VKRlPQpDhulPRFsYDEuLspLh.....u.....sP..PsWPs..PTRGVSEIRLALRa+os.cu.LLRHh+.-.TuTLYL-IVDYPGEWLLDLPhLs.QDYhoWScQhtuLLpG.p.RuEhuspWhthsc..s....LD..PhAs..AD..EspLAcIAsuaTDYL+pCK...pp.GLHaIQPGRF..VLPGD.hAG.APALQFFPhPclss.t.....thhupAcKposhuML+cRapaYppKVVKuFYKsHFhRFDRQIVLVDCLQPLNuGPpAFsDMRhALoQLMpSF+YGp.R................oLh+RLF..SPhIDKLLFAATKADHVThDQ..HsNhVSLLQQL...lQ..-AWQpAAFEGIsMDCluLASVpATpoGhlc.hs.Gc+lPAl+GsRLsD..........GtslTlYPGEVPuRL.........................Pu..tsFWp..p.Q.G.FpF-uFRPpsh......clDcPLPHIRLDuALEFLIGDKL................................................................	0	25	67	110
+2126	PF04327	DUF464		Protein of unknown function (DUF464)	Kerrison ND	anon	COG2868	Family	\N	20.40	20.40	22.10	22.10	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.51	0.72	-3.78	58	1433	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1398	14	197	712	9	103.00	33	94.18	CHANGED	MI+lphp+sp.splhuFploGHAs...........hu......chGpDI.....VCAuVSulshsslNul-plt.phcsphph....psGaLplcl.s.....ppppsQllLcshhluLpsltppYs.ca.....lpl	...................MIpsshp..csc...tG....p....ltuhphsGHAs.....................hu...-a..Gp.Dl.....VCAuVSslshssl.Nulppls...sh...c...s...p...lcht....cuGalpl..cl..sss...................pp......cps...QlllcshhluL.ps.lp..c..p..Ys.-alp.................	0	90	142	168
+2127	PF04325	DUF465		Protein of unknown function (DUF465)	Kerrison ND	anon	COG2841	Family	Family members are found in small bacterial proteins, and also in the heavy chains of eukaryotic myosin and kinesin, C terminal of the motor domain (Myosin Pfam:PF00063, Kinesin Pfam:PF00225). Members of this family may form coiled coil structures.	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.43	0.72	-4.26	175	1757	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1278	1	425	1015	380	49.40	33	66.23	CHANGED	hscLtpcHpp.LDppI..pphppp...s..s.scshplpcLKKcKLpLK.........Dclhplhpp	.......htpLhccHsc.LDccI.pphEss...s...s..ss..sh..cl..pc.LKKcKLpLK.........Dclhplhp...........................	0	96	245	335
+2128	PF04328	DUF466		Protein of unknown function (DUF466)	Kerrison ND, Eberhardt R	anon	COG2879	Family	Small bacterial protein of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	30.10	25.70	20.80	23.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.34	0.72	-4.14	41	1692	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	1243	0	200	511	13	64.60	52	94.47	CHANGED	hhpclpphh+...hhtpsh+hhVGlP-Y-sYVpHM+ppHP-c.PlMohcEFFR-RQcARYuusuu...RC.C	................MFssLupstKYLGQAA+hhlGlPDYDNYV....E.HM+psH..PDp....s......sMoYEEFFRERQ-.ARYGGcGus...RC.C.........	0	32	93	150
+2129	PF04326	AAA_4	DUF467; AAA_div; 	Divergent AAA domain	Kerrison ND	anon	COG2865	Domain	This family is related to the Pfam:PF00004 family, and presumably has the same function (ATP-binding).	25.30	25.30	25.40	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.83	0.71	-3.96	163	2671	2012-10-05 12:31:08	2003-04-07 12:59:11	9	56	1473	5	706	2349	272	120.30	21	27.02	CHANGED	Esppl.EaKpshttstp....................lhcslsAFAN..s....t.....G.GhlllGlp..D...........stp...lhGl.......................tpttpttphhpp.ltptlpPt...........lph.php.......hthpsp...............................................................pllhlp......l.puspts.......................http....sphYhRhuspspt.hs	....................................Esppl.EaKpshpp....p.....................lhcslsA..FAN....s.........p.........G..Ghlll.Glc....D.........ssp...........lhGl............................p.p....p.p.th.p.t.h.t....p........h.t.p..php..s...............lt.h....phph...........h..p..h..p.sp...............................................................pl.l.hlp...l.tutpts............................ht.p.............sthahRhssts....t...................................................................................................................................................................	0	253	490	579
+2130	PF04318	DUF468		Protein of unknown function (DUF468) 	Finn RD	anon	DOMO_DM06450	Family	These conserved ORFs probably are probably not translated into protein [Personal communication, Val Wood].	25.00	25.00	83.00	82.90	20.10	17.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.11	0.72	-3.42	4	21	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	3	0	12	21	0	79.70	78	74.39	CHANGED	hHGTCLSGLYPVPFTHpsHcYPHFsIYISFuGPKYCITALNshlIPLLpHI............LTsphIaTYhNIspKSP.KpPKHKNILlFN.sp	.MHGTCLSGLYPVPFTHpuHDYPHFNIYISFGGPKYCITALNTYVIPLLH+I............LTTQFIaTYsNITpKSPlKSPKHKNIL.FNpNT...	0	12	12	12
+2131	PF04320	DUF469		Protein with unknown function (DUF469)	Finn RD	anon	DOMO_DM08606	Family	Family of bacteria protein with no known function.	21.90	21.90	23.50	23.00	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.35	0.72	-3.23	37	852	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	825	0	116	317	11	100.30	61	90.89	CHANGED	RRLRKKL+lsEFQELGFplshpaccshst.-phDshlDpFI-.hIEspsLsasG.uG...phtaEGhlssp.chG..psTEEcRtsVctWLcu+s.lpslclo-LhDhWa	..............RRLRKKMHIDEFQELGFSVuW+FsEGTS-.EQIDcTVD-FIsEVIEPNcLAFDG..SG....YLsWEGLIChQ...cIG..KCTEEHpAlV+KWLEtRp.Lc-VcsSELFDlWW......................	0	12	33	77
+2132	PF01865	PhoU_div	DUF47; 	Protein of unknown function DUF47	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes prokaryotic proteins of unknown function, as well as a protein annotated as the pit accessory protein from Sinorhizobium meliloti Swiss:O30498. However, the function of this protein is also unknown (Pit stands for Phosphate transport). It is probably distantly related to Pfam:PF01895 (personal obs:Yeats C).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.29	0.70	-5.17	9	1815	2012-10-02 11:27:25	2003-04-07 12:59:11	11	7	1654	7	546	1275	457	205.00	24	94.91	CHANGED	hhhlFtpss.+plhcHhchlspslhthtchhcuhhcGshcpsEcltc-lsphEccADpl++-lclpltpuhFLPssRsDllcllc..DclhDshEcsAhhlhltc...thPc-hc--hhthhppolcshchltcslctl-p.l-suhp.........llpclcplEccsDtlptclhctlas...psh.sshchhhhhpllcplusluDpuEDsu-clpllhhc	................................................................................h...........t.h.phhpths.p.sh.pth.hp....hh...p.t.h.h...p...t...s......p..c...h...p....ph..t....pplpphEccuDplp+clhp.cLsp......s......F....l...TP.l-...R.....-D....Ih..p.L.ssph......Dclh...Dth....c.c.s...u...t....h.h......h...hp......l.........p....t.h...pp..t....hh..phsp.hlh....c.us.pp.h......p.p.s..l..p.t.L..sp.h.h...p.ss...h.p....................phsh...c..lcplEscsDplhcphh.p.c.LFs..........tp..t..h....-...s..l..pl...l...th.+.cIh.-tlEcls...DpspcVAstlEsllh........................................................................................................	1	177	348	453
+2136	PF04322	DUF473		Protein of unknown function (DUF473)	Waterfield DI, Finn RD	anon	COG1935	Family	Family of uncharacterised Archaeal proteins.	25.00	25.00	103.10	102.80	20.80	18.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.19	0.71	-4.46	17	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	54	0	43	55	1	117.30	33	92.22	CHANGED	MchhuLTGIu.psIp-LhpstlRTlEl+SspNlhslpph.psG..DhlFlTssshcDlhsGTpGllApVhphplshp+.h..tps.hhEE+EhhsuRlQLchlGhu+lh.clhppchhpshhV..-	.MchluLTGIucpsls-Lh+splRTlEl+SspNlhslppl.psG..DhlFlTssshpDlssGTpGlIuclhplplspp+.h..tps..h-E+EhhsuRlQLchlGhu+lh.cVpppphhpsshV.........	1	8	22	33
+2138	PF04536	TPM	DUF477; Repair_PSII; Phosphatase;	TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase	Waterfield DI, Finn RD, Bateman A, Eberhardt R	anon	COG1512 & Pfam-B_18715 (release 10.0)	Domain	This family has a Rossmann-like fold. It has phosphatase activity [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.21	0.71	-10.28	0.71	-4.24	162	3085	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	1821	5	879	2585	289	124.00	22	42.17	CHANGED	hLo..sspppplpptl........................pph.Epposs................plhllhh.sh..s............................................................................................................pshcphAhchapp.ht...ls..pptpss.....GlLlhl......uht..-+..p....hpl..su..........tGlpsh.lscshhpp.llpsh...hsth+pspaspulhsulptlsphl	................................................................................Lssppppplpp.tl.........................p.ph...cpp.s..ss................plhVlh..l.ss.h..ts...........................................................................................pshcpaApclapp.ht......lG......ppp..pss...............GlLlll..........uhs......-R.p................lpIp.s.G..............hGlcsh..l.sD......s...hhsp.I.lpph......hsth.+.....p.s..c...astGlhtulpsltt..........................................................	1	272	591	767
+2139	PF04334	DUF478		Protein of unknown function (DUF478)	Finn RD	anon	DOMO:DM06402;	Family	This family contains uncharacterised protein encoded on Trypanosoma kinetoplast minicircles.	25.00	25.00	99.60	96.90	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.32	0.72	-4.12	2	2	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1	0	0	4	0	60.50	64	97.58	CHANGED	MGVQh.sYTNPVLFWGlFEVRGTSKGVGVILTRFF...............l.Ih.lhlhhGF.pts.a	MGVQh.sYTNPVLFWGlFEVRGTSKGVGVILTRFF...............l.Ih.lhlhhGF.pts.a	0	0	0	0
+2140	PF04336	DUF479		Protein of unknown function, DUF479	Mifsud W	anon	COG3124	Family	This family includes several bacterial proteins of uncharacterised function.	21.40	21.40	21.40	23.10	20.80	19.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.51	0.72	-3.93	55	920	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	913	0	158	494	113	106.50	46	55.17	CHANGED	aDHaLApcWppap.sp.P.....LspFsppsYptLpst.....tshLPt+htplhsthhppcWLsuYpchsslppsLpphup.Rhs+ss..Lssuht-lpp.pYppL-psFhsFYPpLhsa	..............................WDHFLuRHWsplos-..P.......LppFlsaAppplhsh.....lPcpPsRFlsL.NsYLWuEpWLs+Yc-h-a.I.ppVLsGMA....s.RRP....R....Lcu....L.ps........SahDL-s.HYssLEscFhpFYPchMs.p....................	1	33	79	125
+2141	PF01867	Cas_Cas1	DUF48;	CRISPR associated protein Cas1	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein.  Cas1 may be involved in linking DNA segments to CRISPR [2].	20.20	20.20	20.30	20.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.77	0.70	-5.33	140	3143	2009-09-11 00:29:59	2003-04-07 12:59:11	11	9	1958	26	807	2515	107	209.90	20	81.31	CHANGED	slalpspGshLphcssslhlpp....................ppc.........................lPlppl..cplhlhGp.lslosthlphhscpsIsltahstp.....G.pahuphhs...........thstsshhph.tQhpthhspptpltlA+phltuKltNttphL.....+htppp...............hpphhpplp.t......h..hpph............p.slsplhGlEGpuuphYapshs.pll................................................p....sapFp....tR......s+RP...P..pD.lNAhLSaGYulLhspshsslhtsGL-PhlGaLH.p...sp.s+.oLuLDlhE.FRPhllDchlhpLl...scphlp.tpcF..t.t...............sshLscpu++phlptapc+	...................................................h........t.lphtttthhh.p..................................ptt...............hhtlPltpl..t.lhl.st.stlotthhthhsp.sh.lhah.st.t.....s..h..hhth...............ttps.h.hhhp.hph..s.t.t...phtlspphht.ph...............................................................................phtplhsh.Eu.t.hsp.hathh...........................................................tht.ap....t+........p.............ts...h..Nthlshu.s.hlhs.h.ttlhhhGhsshlGhhH.......p.t..uhs.Dlh-.h+s.hss.hs.hthh....t.......................................................h.............................................................	0	307	576	708
+2142	PF04337	DUF480		Protein of unknown function, DUF480	Mifsud W	anon	COG3132	Family	This family consists of several proteins of uncharacterised function.	25.00	25.00	30.30	27.40	24.00	21.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.80	0.71	-4.35	53	923	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	913	1	173	537	52	150.80	62	67.31	CHANGED	LoshEuRVlGsLlEKphTTPDpYPLSLNuLssACNQKSsR-PVMsLoEu-VppuLDpLpp+pLlpp..sshGuRVsKYcH+Fsps....LpLsstphAllslLLLRGPQTsGELRoRopRhapFsDlspVEssLppLtp+p....ssLVscLPRpPGc	...LTAhEARVIGCLLEKQVTTPEQYPLSlNullTACNQKTNREPVMNLSEuEVQ-pLDsLl+R+.hlRs..SGFGsRVoKYEpRFCNoEFGDLKLSuAEVALlosLLLRGAQTPGELRoRuuRM.a-...FuDhuEVEusLEpLAsRE.....sGPhVVRLsREPGK......................	0	32	81	128
+2143	PF04338	DUF481		Protein of unknown function, DUF481	Mifsud W	anon	COG3137	Family	This family includes several proteins of uncharacterised function.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-10.91	0.70	-4.61	121	1242	2012-10-03 17:14:36	2003-04-07 12:59:11	7	4	1038	0	283	927	368	208.30	31	76.69	CHANGED	schGht.hsoGNTcosshsuphp.hphcts.pachph.phph.h..............p.............pss.sp....s........oscpahhshphcaph..scphahaupspacpDcFs.................shch.ctshusGhGaphhs.scpt...pLslcsGsuaphp.........chpss.............pspsph....hspsshsa.paplscshphppphph...........h....sssshphps-suLpspl..sss..luhcluhphcasops.ss.ut....cpsDophshsLsYsF	.......................................................................................................h.phGah.upoGNTc...os.S.l..suc....ss..hsah.st...pp...tasl..husupp.............s..................sss.sc.........c.............ou-+assuscscapl.......s-hs.......Yl.a..G.pusahs...D+as.....................................................uYc....p.+.ss.l.s.uGhGhQhls..sshp.......shch..E...hGPGhRas........cascs.................................sscsps......luhuussY..ta...p.l...o...-..s.scF..s..pslol..................................h.........u.sp.cT....slsSE.....su....LsssI....scc....huLKluasl.sasopP.Pp..us.........c+oD.ppoolsLsYs.........................................................	0	92	164	226
+2144	PF04339	DUF482		Protein of unknown function, DUF482	Mifsud W	anon	COG3146	Family	This family contains several proteins of uncharacterised function.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.14	0.70	-5.59	99	853	2012-10-02 22:59:21	2003-04-07 12:59:11	7	7	784	0	330	1004	1212	354.00	38	92.18	CHANGED	ulspIssspWDul....s...............s...................s.......tsPFlpasFLsALEpSGssss..cTGWtPpHLslp.cs.......s.....pl....................lussPhYlKsHShGEYVFDauWA-AapRsGhcYYPKLlsulPFTPssG.RlLht...st.cpsth.tpsLhpultphspp....pslSShHlhFss..ts.-tth...........hp..ptGh...............hpRhspQFHWpN......pGYpsFDDFLusLsS+KRKsIR+ERcps.tppGlplchLpGs-l..spppW.ctFapFYpsThs++..WG.pPYLo+pFFphlscp.hs-pllLlhA....c............+.sGc..lAuALshh.......u.....u-sLYGRYWGshEc..hshLHFEsCYYQuI-aAItpGLpphEuGAQGEHKluRGahPssTaStHaltcsuhcpAlscaLppE+ttlpthhctls.pth....PF+c	....................................................................................t.lsplstspWsul....ss........................................t.sPFlp+sFLpALEp..SG..ss....ss..poGWtPpHlslhcs.....s........pL....................................................lussP....h...YlKsH.ShG..EYV.FDauWA-A.apRt.G..h..pY..YP...K.Lhs...ulPF...T.Ps..s..Gs.R.lLst.......t...p...t...t.th...tttLh.tulhp...hspp.....ps.l..SSh...H...l.h.....Fss.....t...s.....-..t...th..........h..p.....p.....t..Gh..................................ht.Rhsh...Q...F.HWp.........N........................pG.......Y.....tsFDDFL.s.s.L..su+.KRK.slR+ER+ps...t............t....t.Gl...p.hchl..p.G.scl...sp.t..pW.chFaphYtsTh..tc+....hu...pP..Y...L......s..c.......pFFphlu..p.p...h.....s.....-.p..llLlhA...c........................c..s..G...c...lAuAl.shh.....u........................sssL....Y....GRYW...G......s...h...c..c......h...s...t.....L..H..F...E...s.C..Y.Y...Q......u.........I-aA.ItcGLpp.h.E....u.G.......A....Q....G....E..H.....KlsR..G..ahPsh.T.aShH..als....csuhppAltcaLppEpttl.pthhptl.p.pt..Pa+..................................................................................	0	81	191	269
+2145	PF04467	DUF483		Protein of unknown function (DUF483)	Waterfield DI, Finn RD	anon	COG1790	Family	Family of uncharacterised prokaryotic proteins.	25.00	25.00	39.40	33.20	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.48	0.71	-4.07	4	23	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	23	0	16	23	3	120.50	47	61.63	CHANGED	h-hQI.lsc+hpshlRs..tl-shIs...sELGlhR.h.stp.G+LLsYP-CCl+SasEspR.hsh-tcaLtEsuEhs...h.....hGhhhIhhP....SsFIPCSLcCp-AlccshIuhhh+-EFcchh-Lcc.Lh	..........................LchQIEIVcKYpscVRP..AIDPhVS...oELGIYRRLD.DhElG+LLsYP-CCl+SFsEssR..huIDp-HLKElEchchc.........................s..hYAIlLP...............SGFIPCSLcCccAlcptLIuhlsccpac+lLcLEcEL.............	0	4	8	12
+2146	PF04340	DUF484		Protein of unknown function, DUF484	Mifsud W	anon	COG3159	Family	This family consists of several proteins of uncharacterised function.	24.20	24.20	25.30	24.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.30	0.70	-4.88	6	1222	2012-10-02 14:34:25	2003-04-07 12:59:11	7	4	1147	2	271	774	583	214.30	37	92.58	CHANGED	ts.pssLsspsVs-YLppHP-FFhcascLltcLslP+psussVSLschQLsRtRp+hccLccclstLhs.AtsN-plFhchhtLphsLhcApSLsDslppl-phs+chhhtshspLlLhsDsth..u.u......lupcshp.sthspLsscpshhGhLphs-thhLas-.-ApplGSsAll.Lu....pt.hGllAFuSpDspHFpsuhGT.FL+alAplLschLc..RWss	.....................................ttLss.csVs-YLhcpP-F...Fh+pschlcsl....c...l...P...H....s...s...p...u...sV.SLVEhphtRhRp+lc..hLE-phshLMcpAtsN-sLFh+lhpLptpLh.sA..s.S...Lp-hl........hp.h...pchsR-.lhhs.s...s..sL...+.L...a....s...D......p........hp......h........u...........u.......h...........p.....h...s...l..u....c.........p..s..h...c....s.........l.p....h.....p........+........L......u.....t........p............p........t.Y.....LG......s...L.s....s............s...E...h....h....h...l..........h.........s.........p...A......p....tl................G............SlAhshLs................ssu.s...l..GlllhuScDspHapsu.GT.hLpplAh.hLsclLp..Ra..p.............................................................................................................................	0	52	138	206
+2147	PF04341	DUF485		Protein of unknown function, DUF485	Mifsud W	anon	COG3162	Family	This family includes several putative integral membrane proteins.	28.00	28.00	28.20	28.00	27.80	27.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.91	0.72	-4.27	132	1454	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1255	0	378	871	80	90.20	38	81.72	CHANGED	lpssPcFpcLhpcRppFuhsLohhhLlhYauallLlAassshLup.ls.G.slolGlslGluhhlhsallTulYVp+ANppaDtlspplhcc	.............lpssscFp-Llc+Rp+FuhhLollhLshYhuFlLL.lAauPshLu.sPlt.G.slThGl.s.lGlGlI.lhoFlLTulYlh...+ANscFDclsppllc.................	0	96	224	312
+2148	PF04342	DUF486		Protein of unknown function, DUF486	Mifsud W	anon	COG3169	Family	This family contains several proteins of uncharacterised function.	25.00	25.00	41.40	41.30	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.55	0.72	-3.99	4	583	2012-10-02 19:55:49	2003-04-07 12:59:11	7	1	574	0	179	409	45	109.10	55	92.52	CHANGED	LhosLLLhsSNVFMTFAWYGHLKphss+PhllAsLlSWGIAhFEYLLQVPANRIGassLoVuQLKhhQEVITLhlFVPFSVaYLppPL+LsYLWAuLCllGAVYFhFR	...h.hsllLLlhSNlFMTFAWYGHLK.....h..h.........s......s......p......P.....lh.....hslLlSWGIAhFEYhLQVPANR.I.G.ap....s....a....osu..QLKlhQEVITLsVFssFo.V.a.Yh.p.E.sL+hsaLhAhlhl.luA.VaFlF+........	0	56	129	152
+2149	PF04343	DUF488		Protein of unknown function, DUF488	Mifsud W	anon	COG3189	Family	This family includes several proteins of uncharacterised function.	22.20	22.20	22.20	22.60	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.63	0.71	-3.74	219	2338	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	2035	0	577	1579	120	111.60	33	83.11	CHANGED	plcchhc...hhpssGh+......lLVD.RhaPR.....G.hsK-slphsl..............Whpc.lusspclRchat.tt....p...hsphhcpYtpclps...........pslpcLtp.hs.ppt....lsLlhut+-.p+.......sHthlLt-h.L	.............................................p.hcRlY-...htps-GhR......lLVD.RlWP..R..........G...lpK.pshth..D.....................WhK-.luPSs-L.....Rc.hap..p-s...c.................aspFtcpYttELtp.p...t....................pthccLts.ls...p...pp.......slsLLauu.+.c..ppp.......NHAhVLt-hL...................................	0	172	365	488
+2150	PF04356	DUF489		Protein of unknown function (DUF489)	Kerrison ND	anon	COG2915	Family	Protein of unknown function, cotranscribed with purB in Escherichia coli, but with function unrelated to purine biosynthesis [1].	22.90	22.90	24.60	38.60	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.09	0.71	-4.71	56	1032	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1015	2	152	528	101	191.80	55	92.10	CHANGED	-pslALAGlhQAupLVpplA+pGps.-pss.....hpsslpSllppsPs.....sshsVYGspp....sL+hGlcsLhstLs.......tspspss-lsR.....YhlullsLE+KLs+ssshhspLupRIsplpcQhpHF..sh............tc-slluslAulYsDsISsLusRIQVpGsPphLQpststp+IRALLLAGIRuAVLWRQlGGpRhpLlFuR+pllpp	.......DITLALAGICQuA+LVQQLA+pGcC.Ds.DA.....LcsSLsSllshNPu......STLuVFGGs-...tNL+lGLETLlusLs..........ssppuhsuELTR.........YsLSLMsLERKLous+sAlssLGsRIstLpRQL-HF....DL............ps-slhSuhAuIYlDVISPLGPRIQVTGoPulLQsPpVQuKVRAsLLAGIRuAVLW+QVGGuRhQLhFSRp+Lhs.p....	0	30	66	113
+2151	PF04357	DUF490		Family of unknown function (DUF490)	Kerrison ND	anon	COG2911	Family	\N	20.40	20.40	20.60	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.40	0.70	-5.36	151	2461	2012-10-03 05:41:17	2003-04-07 12:59:11	8	21	2009	0	647	2270	560	348.80	22	27.68	CHANGED	pp..htst....sssGplplsG.....slsh..................tthp......hsLsl.ph.pp..htlhpssthp.......sp.l.sus...lplsG..sh......shplsGp..l.plspuplpl.phs..ssts.s...........................shhhhttt...............................t..h.h.h...thslplph.....ss..........plhl...............cu.u...l..csphs.G.sLpl..........sts.....ss.hthsGplplh.c.Gp.hph.....h.upphpl.p.pGplsas.G.sh....pPhLs.lpAhpps...........................ss...........pls.lplsG...ssspPp........lph.....................p.S...pP.................s.h......................sps-lluhLl.hGp....shsshu.............ttsthssuhuslhts...sshtshh.sp.........ltpt.......hGl...s.slsl.......sstt.........t.......................ttshslplGphl.ssclhlsht..hsh.ss.t...........tphp......lcYpls...pphplcups..s................tt......tlslhaphca	...................................................................................................hht........stpGpl.pl.sG.shsh........................................tthpshp.....hp.l.sh...pu...sp...........hp..l...hs...sshhp..............hp..l..sss...........ls.l.pu......ssp......thslsG.p....l...sl...stup....l.s.l.phs...ssssss..........................-l.shlsps......................................................................................................pt.......ts.hsl...phslp.lp.l....ss..............slpl...........................suhG............l..cupLs..G..s....Lpl..............sts...........ps...hthsGplsl....c..Gp..ach..................h.Gpclhl..c...cG...p..lh.....Fs...G.s.............pPhLs.lpAhpps....................................sl........................hss.l.plsG..........ss..pPp.........hpl................................................................h..S..pP..........................s.h........................spppsLohLl.hGp..........shssss..............p.ssu.hsshh.h.u....s...sphh.sp.....lsps...........hGl...s..slsl.................so.ps......................................sssspls.lut.hl.tspl.l......phs..huhhss.s..............................phs..........lcYpL.....plhlpuhs..s.....................sp....ulsl.hYphca...................................................................................................................................................................	0	213	426	555
+2154	PF04361	DUF494		Protein of unknown function (DUF494)	Kerrison ND	anon	COG2922	Family	Members of this family of uncharacterised proteins are often named Smg.	20.60	20.60	20.60	22.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.91	0.71	-4.55	48	950	2009-09-11 06:38:14	2003-04-07 12:59:11	8	1	940	0	158	376	87	154.50	57	99.23	CHANGED	MFDVLhYLFEsYhcs...-.-hpsDp-pLsc-LtcAGFcppEItcALsWL-sLushp......................tshhtsssssoh.RIYospEhp+LsscsRGFlhFLEphsVLsspoREhVIDRlMuL-ssplsL--LKWllLMVLFNhPGpEsAathhE-Lla-pps...thlH	..............MFDVLMYLFETYIHs..........EAELpVD..QDcLpp-Lo-AGF-+EDIYNALhW.LEcLA-hQc..................s.scPht..hso...D.PhSh..RIYTsEEs-RLDssCRGFLLFLEQIpVLshETRE.MVI-RVhAL...Ds...sEF...-L-DLKWVILMVLFNl....PGsENAYpQMEELLF-ss-.GhLH...............................	2	38	88	123
+2155	PF04362	Iron_traffic	DUF495; 	Bacterial Fe(2+) trafficking	Kerrison ND, Mistry J	anon	COG2924	Family	This is a family of bacterial Fe(2+) trafficking proteins.	20.90	20.90	24.90	24.90	19.20	18.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.95	0.72	-4.55	65	1349	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	1339	3	260	617	383	87.20	59	96.06	CHANGED	Mu..RsVhCtKLp+EuEGLDhsPaPG-LGc+Ia-sVSKcAWppWhc+QTMLINEp+LshhDscsRcaLpppM-+FhFsps.sspspGYsPP	...........................MoRTlFCshLp+EAEG.DFQ.YPGE.LGKRIaspISK-AWupWp++QTMLINEK+LNMMssEcRKhLEpEMssFLFEGc.-..s+lEGYsP................	0	61	135	203
+2156	PF04363	DUF496		Protein of unknown function (DUF496)	Kerrison ND	anon	COG2926	Family	\N	21.50	21.50	22.30	23.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.10	0.72	-4.17	13	780	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	775	0	75	202	1	94.80	77	85.78	CHANGED	hpsVLEhVRhhRRKNKLpREIsDN-+KIRDNpKRVhLL-NLh-YI+ssMShEEIpsIIcNM+sDYEDRVDDYIIKsAELSKERRElS+KlKphKc	...................FQDVLEFVRLFRRKNKLQREIpDsEKKIRDNQKRVLL.LDNLSDYIKP..GMSVEAIQGIIASMKuDYEDRVDDYIIKNA.ELSKERRDISKKLKAM..GE..	0	6	23	50
+2157	PF04365	DUF497		Protein of unknown function (DUF497)	Kerrison ND	anon	COG2929	Family	\N	23.70	23.70	23.70	23.90	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.80	0.72	-4.06	96	916	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	614	1	261	806	130	76.80	33	83.44	CHANGED	WDps.KsptNhpKH.GlsFt.-AttlF..cshtlhh.................Dtccs..sEpRa.hslGh...ss+llhVlaThR....ts......tIRIISAR+As++Ec	....................................WDts.KsppNht..K....H.GlsFp.-Attl.F..ss..tlph................pDtpp....sEtRa.hslG.....hh.........st.p..llhV.saT.R........sp........hlR.lISs...R+Asc+E........................................	0	68	179	219
+2158	PF04430	DUF498		Protein of unknown function (DUF498/DUF598)	Waterfield DI, Finn RD	anon	COG1504	Domain	This is a large family of uncharacterised proteins found in all domains of life.  The structure shows a novel fold with three beta sheets.  A dimeric form is found in the crystal structure. It was suggested that the cleft in between the two monomers might bing nucleic acid [1].	20.90	20.90	20.90	22.80	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.42	0.72	-4.51	101	971	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	868	12	443	853	223	109.00	28	70.39	CHANGED	lpuY..usGthpl.s....shp..........apuulllhPsuh..hsW..s..............stphppls.......hcchshlhsh...ps-llllGTGtc..hthlssplhptl.pptG..lslEsMsTssAsRTYNlLhuEs..RpVAAALl	.................................................................lpuYussthpl.s.....shp..............hps..s..lll.hs...suh..hsW..p.................................................sps.ppls........................psh.shlhth......p..s....-llllGT.Gtp...hth..l.s.sp....lhthl....ppt..G..IulEsM.......sTssAs+TYNlLhuEs..RpVuAALl..........................	0	132	244	338
+2159	PF00674	DUP		DUP family	Bateman A	anon	Pfam-B_99 (release 2.1)	Family	This family consists of several yeast proteins of unknown functions.  Swiss-prot annotates these as belonging to the DUP family. Several members of this family contain an internal duplication of this region.	21.10	21.10	22.30	22.00	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.64	0.72	-4.09	32	469	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	27	0	183	427	0	103.60	29	52.60	CHANGED	hlhhts.....hhhss.h.hhllhshhhhhhhhhsF.sht....hhsp-achphLhElIsc+Pu.tuc-WcpIAhpMNpYLF-cclWpT.YaFassp-CppaFpphltthhstKps	..........................................................hh............h.h.hhhhhh.hhhhs...h..h.h...hh..lhsh.php.......hsp.ph...hphlp-llpppPu..sspsW-tIA...tphNpYLa.-p.+hWpo.t.h.aFasutcCpphFpphlhp.hs.p..p................	1	36	47	123
+2160	PF04465	DUF499		Protein of unknown function (DUF499)	Waterfield DI, Finn RD	anon	COG1483	Family	Family of uncharacterised hypothetical prokaryotic proteins.	21.10	21.10	25.60	24.10	19.70	20.90	hmmbuild  -o /dev/null HMM SEED	1036	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.71	0.70	-13.89	0.70	-7.00	5	220	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	188	0	107	235	48	429.10	21	44.17	CHANGED	PcALcDcEV....L+sYcs-KREplcElu-hIcsl..ulclVlVYGKss..lPpPs+PL-hsst+lKTlWGYIAapLG+YElVEcsD+NLTsPshElL+-LlpGc+VLlLIDEIuDYlDslppSusEE-RsYucNVusFLD+LApALos...SpSlMVITIPMEcEGts..lKspcEYcR..-lVRulh-AVoRVuGtclYoPV+h.GRcsELlEVLKKRIFK+lDcsE+c+sLp+L......REshus.+EIFG-sSpFhcEIccTYPFHPEYIpVLRsIIERls.LQRTRDLIRI...TRIVlRc.LlcuhE....sPsLIMPaHIDLs--cI..+GlLFucpocYuDYtoIa-s-lIs-EKl...Kchu+PELu+IILoYIFL+TYPaDS.....................Ppshs-FPTsccIARuVYEPEhFcpppWlPsDIKDslEEI+uSl+FlaLs...++Dus..aWFWRlANVochVcSKsEELIEos+G-VhspLVKp.lc+Ll+EuKSlcpuRu+tsps......caVsFFcspsVIVoK..-PQElhDos-YKLhVlVpDDV-EDhLc+lIFhhsousRTY+NTVVVlYlusc.uM..........................-oLlEhpAplhAC-cVM-cI+EhY.........uKYGKDVlcIQ+ohVc-I+c+ALED.LENQIlpsFR+VAYPctDG....l-pspAsASSKSVlENVYSALsS+..GKIV.-EFDFEpLtshLc-.Vslcl.+sEGYsVSELhNlIpS..NPcLPMIcpccLh-AIK-AVccL-IG.IERcG+IaFK+IY..KEIPch.--E+GcsPusVR..........cDVILPt.....-EALpRQlpELLc-EK--It-+sGp+Ycl+h..............WYE..IYLPppNhplPL+slV...scEscV+DE..ptlhaGaIVE++EEcpIl+GEF-..LpVucupIcGKPG-sV-lcV+lpPlGDtchsVELsosaG-LsoccVpL.EGpsl+lpW.phplsc.+c.shIcuKS.-s+ttphElllIPKlEp-IlEVcElcEpHKGslLlSI+..Slcs....lDoL-pIsc.aEGs........lsGSLEl.....EcPlWcVpF..cssDhcVFcaIluElc-aLGSpsplc..V-lchSEElhINDLlhEKL+PLsG+VKF+lKKG-.pc	.........................................hhh.shs.......................................................................................h...pT.lWG-lAhQL.......G...........t.............ap...h....l...tp.t.Dt.p.t.hs...P.G.tphlpc.Lh.....p....t.....p.P..sLILlDElssYhc......phh.tst..s.h.s..sss.htpph.sF.lp....s.L..o.c.A.sps.....s.p.s.h.lV.l.o.ls.........s...s.................p...t..t..............................tt.....t...h....t....p.........................................thl.ppL....pp....hhs.Rl.t....t..h.p...Ps.........stp.p..hacIlR+R...LF...p..p.......l.......s.t....p....t......t.......p...p....sh....pph...................tphh.p.p............p.............h....s.....p.........p...s.....p....a.........tcc.lpp.......uYPhHPc.lh-hL.h.c..h...ssh....s.FQRTRGlLRl...hutll+p.La.pp.tp...............ts.LIhstp....lsl.ss....pl..p.......h.h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ttttt....................................................................................................................................................................................................................................................	0	43	78	94
+2161	PF04366	DUF500		Family of unknown function (DUF500)	Kerrison ND	anon	COG2930	Family	Proteins in this family often also contain an SH3 domain (Pfam:PF00018), or a FYVE zinc finger (Pfam:PF01363).	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.40	0.71	-4.69	74	1081	2009-01-15 18:05:59	2003-04-07 12:59:11	7	22	629	0	603	1018	204	114.40	29	34.00	CHANGED	hsG.uuhGh.QlGs-hoDhVhllpspculcshhp.uphoLGussSlAAGPlGRsupussssth....u....................................................................slaoYS+o+...............GlFAGloL-Guslhpcp-s..NpcaYG..........plsspcILtGps.s..........s....ss..uptL...hpsLpph	..........................h.susuhGh.QhGsp.tchVhlhpspcAl..c..sF...pp...ssho.lGuss..........o..........lA..s.......G.s.lG.t..sup.s.ss..s.sst.....u...............................................................................slh.s.a.s.p.o.+...............GLauGlol-Gohlh.p..tt...s.thYt...........h.....l.h...t...............................................h................................................................................	0	172	359	505
+2162	PF04417	DUF501		Protein of unknown function (DUF501)	Waterfield DI, Finn RD	anon	COG1507	Family	Family of uncharacterised bacterial proteins.	22.60	22.60	23.20	23.10	21.70	22.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.73	0.71	-4.33	43	550	2009-09-11 10:23:03	2003-04-07 12:59:11	7	4	523	0	173	424	260	123.50	47	54.26	CHANGED	VutRCssGhPsV.lpotP.LsDG........................pPFPTlaaLTsPplsttlS+LEupGhh+chpccLspDt-LtstatpAHcpYltcRpplh........................h.tlssh.usGGhss......+....VKCLHshlActLAs..ssNPlGchslsh......l	..................................................luhRCs.sGpPsV.ltTtP+LssG......................................................oPFP.ThYYLTsPthsuthS+LE..us.G.lM+cMscRL.....up..D....t..E....LAstYcpAHEsYlAcRstlt......................................................................shh.s.sh.SuGGM..Ps...............R..........VKCLHsLlAHu.......LAt...GPGlNPhGDEsls..l.........................................	0	68	127	162
+2163	PF04367	DUF502		Protein of unknown function (DUF502)	Kerrison ND	anon	COG2928	Family	Predicted to be an integral membrane protein.	20.80	20.80	21.20	21.00	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.52	0.72	-4.28	140	1039	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	869	0	414	929	1403	106.80	31	47.23	CHANGED	lllsllh...l.hllGhlspshlG+tllphhEp.llpRlPll+slYsul....Kplh-slhssppps.Fpp....sVLlcaP..pp.GhasluFlTspstsclttth............chluValPToPNPToG	..................llslhh.l.hllGhhs.p...s.h..l..G..ppll.phh-t.llpR.l.PlV+sl.Ysul....K.Q.........lscslhsspsss...F+c.................sVLlc.a.P......cp.GhasluFlTupss.sphttthtp..........-hluValPToPNPToG...........	0	128	287	356
+2164	PF04456	DUF503		Protein of unknown function (DUF503)	Waterfield DI, Finn RD	anon	COG1550	Family	Family of hypothetical bacterial proteins.	21.20	21.20	23.70	26.50	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.49	0.72	-4.39	79	654	2009-09-13 11:37:40	2003-04-07 12:59:11	7	2	651	1	239	472	24	88.80	34	91.95	CHANGED	hlus.lplclhl.ssspSLKEKRtll+slls+l+p+FNVSlAElsppDhapcutlGlusVusspspscphlppl.ch...l.-pps.-h-lhshchE	......hluhlphclhl.s.-s+SLKEKRull+slls+l+p+F.N.VSlAElspp.DlapRstIGlusVSuspspscchlsplhca...l...-uts.EhElhpsch................	0	109	193	227
+2165	PF04457	DUF504		Protein of unknown function (DUF504)	Waterfield DI, Finn RD	anon	COG1531	Family	Family of uncharacterised proteins.	22.20	22.20	22.20	22.50	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.09	0.72	-3.81	36	171	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	169	0	131	171	3	53.70	33	12.31	CHANGED	hlsYhcR..s.s......sh.pplshspltphpsthlhh........-shIPhHRIlcI..hpcGcllWcR	................lsY.DR...ht..........sh.cclshsphcptpsshh...............-phIPhHRIlhlh..+p.....cG..cllWcR....	0	40	72	106
+2166	PF04458	DUF505		Protein of unknown function (DUF505)	Waterfield DI, Finn RD	anon	COG1542	Family	Family of uncharacterised prokaryotic proteins.	28.50	28.50	28.90	101.90	25.40	28.40	hmmbuild  -o /dev/null HMM SEED	591	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.88	0.70	-6.39	5	33	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	29	0	22	36	0	543.50	33	98.34	CHANGED	MlLpKRHAElL+clKEscppsEhctKlsE-Fcpcsl.....hELEltGLs+LcGsscacLT-AG+phsphLtEhlDKhsLEc.P-pW.tp.RWlGSEIIpMl+hscLs.G+VPEcWtctLcERGLA-E.........ssLTcaGKslLElY+EoHP+LYlTsElAuaIR+MPcGPGshcphlpYKsTlshGDNIlpALEAMRLLlISPPs-sG+sYALTuLGptVcpALchsPsss+sLILcclhEDFhsh.....pcLc-uEcsscLEcuGasscGsLTchGE+lh-sYKhhGKs-ahslPsasLE.DEl+lLKsI-+LhKKaEcNP-llPThKEIcR.h.....................................................EahRsDlD.lsssL+sLES+-LIc+cls+cG....KssYhLTEaGE+VL-s.....lusVoA-GVKAIThocu.F-uPssEWlccA+-EGLV+sGAlT-KGRhYu+LS+cIKRKPaLT+aEhplLtKlP+KuhIcR-cLlEhlpDcVGuEE+cIlcALucLEAKGFV-EL.NssVpLTEAG-clKTAIcsupp.Ellcl+aPVTPssaRlLKAIYDptcpas+tcKl+tpPKsaKt.....lcKcLuLosEphKKsLsLLRplGFlGppuLTEAGlsLLcAa-	.MllpKcHh..hLpclhppcp.tchptthhEchpp.csl......ELplhGLlch...tss.tphpLTauG+thh.hLt-.....................hhcch.................lp....p.P-ta.ttaRaluSElIuMlchutcs.uc.l..st..h.hc.tLcERGhAc-..........ssLophucslh-lY+.ps+P.clhlss-lApalRcMP.GPup.......pshh.shssp.hthLEAMRLlsaSlP..pu-sauhTsLGptlppAlphh.shstc.sll.c.chh...tDh.t.......ptlp..ch..cpph.hphhhh.stpGplp.hGcthh-sY+lhpcts.hsh.saslp.pEhclLcsIcclh.c.+.h-psP-.hPT.cp.Ic+.h.....................................................pahcpsh-.lptsLasLEuFsLlcpc.pcp......+.sYhlTpaGccVl-t.t..thpslousuVKulThscp.hssPshEWhppAccEsllusutsTppG+hYtcLuhphcRhPhlT+hEhplLppl.Pp+t.h.ts.hhc...shsht-Eccl.....ALscLEA+GhlchL.sshlhhTEhGchhKcAluus.p....shthPlsPhhhRlLpAltchGshas+tpKlRh.PcshKc.....hh.Kh.uLs.-phccsl.lhR.stalGcpulsEAGlhLLcAh..............	0	11	13	18
+2167	PF04368	DUF507		Protein of unknown function (DUF507)	Kerrison ND	anon	COG2952	Family	Bacterial protein of unknown function.	23.00	23.00	25.60	25.40	22.60	21.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.17	0.71	-4.65	20	269	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	241	0	73	139	10	164.00	43	99.34	CHANGED	MRL+ht+lPYIApKIshDLhssualcl.spsl-sltpphpcILcEslpcEctL-E+s+ElLEcpp-E..h-hhplDc+phFahlK++LAs-hshhLs...........hEDRasploHpIL-tLhcpchIc.asVs-NplKNlIasuIcsalKta-cIEctVhcKIcsYK++llsGo-Ea-llacKLYEEEL+KRGhl	..........MRlKLsHIsaIupKlhhDlhpSshlEl.KsphEpLp.pIhplLEc-lhpEctLDEcs+ELLEpppDE..hE..h..MphDc+phFWhlK++LA.-hslhLs............EDRtNcLuHpIL-cLl-pDhIp.Fh.......VSENpl+..NlIapSI-sYlKh.YEclEsEVaEKIpsYKpK.lsGS-EY-LlFEKLYpEELRKKGh.....	0	28	58	71
+2168	PF04370	DUF508		Domain of unknown function (DUF508) 	Finn RD	anon	DOMO_DM06371	Family	This is a family of uncharacterised proteins from C. elegans.	25.00	25.00	33.70	33.70	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.95	0.71	-4.60	2	11	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	5	0	11	9	0	141.30	44	57.13	CHANGED	pPSthoTcsspps.spssTSuoShssuSpppSlPo....Ta.ssapphst+hVTMVpVKFlLlHpDshpRRsQShFTDEF.SDCRLE-VllNFpQLCsRQLhDtphpPRLSYCIGElshpsSKPV.usDhuKTLsQLAsopslhQhulIVD....Nhc.	.....................................psssSss..S..ouS.s...Ssh..hSlPph....Ta..u.s.ph..p.p..ou..KhVhMVaVKFlLLHhDlh+RpsQSsFsDEFsSDChLpDVlhNFpQLCsRQL+s..p..chpPRluYCIGEls.hNSKPVhppDLtKoLAQLAsopolhQFuLIsD........st..	0	1	4	11
+2170	PF01871	AMMECR1	DUF51; 	AMMECR1	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	This family consists of several AMMECR1 as well as several uncharacterised proteins. The contiguous gene deletion syndrome AMME is characterised by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1 [1]. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery [2].	25.00	25.00	28.30	28.10	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.00	0.71	-5.13	76	937	2009-09-11 09:06:12	2003-04-07 12:59:11	12	8	800	7	555	903	86	170.30	30	62.01	CHANGED	llplARpslpptLpstp...............hssthpp.ptusFVTl.cp..........ps...pLRGCIGthps..........tsLhcsltcsAlsAAhcDPRFs..Plptc.ELsp..lplEVolLos.c.ls.......h..cplc..lG+aGlllct......G.hhpGlhLPQVssEpsW-tppFLsphsh.KAGls...sssW.ppssclhpFpupl..ap....E	.......................................h.hthshpsl.thl.pttp................t.h.s.t.th......pp...ptulFVTl.cp...................ctpLRGCIGohps..........tsLt.psltchAls.u...........Ah.cDs......RFs..Plptc.E.Lsp..LphsVol.Losh.E.hs..............................................sh.tchc.....lGpaGlhlch...............................s.tpsus.hLPpV.hEp.sas.p.p.p.h.l.s.plhp.KAGht.......s....p.pshclh+apsphh.............................................	0	209	357	469
+2173	PF04459	DUF512		Protein of unknown function (DUF512)	Waterfield DI, Finn RD	anon	COG1625	Family	Family of uncharacterised prokaryotic proteins.	24.60	24.60	24.70	25.60	24.30	24.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.17	0.71	-5.25	60	441	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	416	0	174	431	193	194.80	30	44.54	CHANGED	VPVGlT+aRt..sh.tLpPlstcpAtcsIsplcphQcchppchGstFsahuDEaYllAGpslPsht.YpshPQl-NGVGhl+.Fhcchtcthpp.ls.......pppcholVTGphstphlpplhccL.sthpGlplplhsltspaaGpsloVsGLLTGpDllptLpt.....p-lG..-tlllPslML+p.......spthFLDDholc-ltpp...Lssslhllcussc	.....................................VPlGlT+aRp......tlhtLpshspcp.A..tcslpplcphQ..........cchhp.ch..GppahahuDEaY.......llA.....s.....p.lPs.phY-s.asQlENGVGhlRhhhpp.hppshpp..l.......................httppphollTGphuhthl.pphhcpl...p.....th...sl...p.lplhslpNcaFG.pslTVuGLlTGpDllppLcs..............................pplG....-tlllPssML+p.................scp..lFLDDhol.c-lppp...L.t.hplhlsp....t......................	0	71	129	159
+2174	PF04375	HemX	DUF513; 	HemX	Kerrison ND, Moxon SJ	anon	COG2959	Family	This family consists of several bacterial HemX proteins. The hemX gene is not essential for haem synthesis in B. subtilis. HemX is a polytopic membrane protein which by an unknown mechanism down-regulates the level of HemA [1].	29.30	29.30	29.50	29.30	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.09	0.70	-5.87	5	1205	2012-10-02 17:03:51	2003-04-07 12:59:11	9	3	1165	0	207	918	162	356.10	38	87.20	CHANGED	uusPp-sAcpssssSoPsAscsss+susussLAulALLlA.LGLGAGGaha............uLQQlschps+s-ALApclpQlssAp-s........spcpplpclp+ssp-thcQLc+pLushs+plsplQppVuslpuu......sssDWLLAEADaLL+LAuRKLhL-pDVsTAsuLLcoADspLAshNDPulpAlR+AlAsDIssL+AlPpVDpsGlhlRLssLpNQIDsLsLlssshc............tuspsusupAlo-ulu..............-WppNLp+Sl+uFhssFIsIRpRDsoshPLLAPsQchYLRENI+L+LpsAthAVhscQ-ElYRQAL-sAuoWlcuYFDT-sssspuFhtplDpLAcQslpV-lPspLQApssLpcllscRlpslph...ulutsAscu	........................................................................ppstpt.s..psss.p.s....s..s.s......p.t...t.......p....p....p.....s....s...u.....h.....h....L....u.....s...l.Al.s....l..A....LA.h.G...s....G..h.ah.a..............................................s.p.Q.Q.s..s.p.......s....s.......p...s.sA...L...ss...QL.s..sh.p..pupp................................sppscL..c.s.h...h...p...p....p...s..s...p...l.c...p....s..pp....p............p....s...h...s...cplscl...Q...pp.l.uslsup..................sscsWLL..ApADaLl+LAuRKLa.-pDVsTAsuLLcoADupLAch..NDPuLlslR+AIssDIusLpul..s..plDhsGllL+LspLpsQlDs..Lt...L..u.s.s.s..s.s.........................................................................tu.s...h..s..s.c....u.pp..l.S.uu..lu..........................-W...p.........N...L...p+...Sh...p...s.......F...hcsF...IsIRRR...Ds.s.s...h.PLLA.P....sQchYLRENIR.RLLsAtpAV.++QpEsY+puL-ssusWl+uYaDsc.cs.sT+uFLccl-..pL.upQsI..s.h...-.l..P.-...pL.p.S.p.shLcclhppRhpph...............stst.......................................................	0	34	94	156
+2176	PF04415	DUF515		Protein of unknown function (DUF515)    	Waterfield DI, Finn RD	anon	COG1627	Family	Family of hypothetical Archaeal proteins.	25.30	25.30	25.30	49.70	23.90	25.20	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.27	0.70	-6.23	6	64	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	39	0	46	66	5	243.40	20	93.40	CHANGED	ccpsP..................................KspPhKpPpRRss...................Rluo.+p+......................EcRpRlIIGA.VlslIIlhhshulYhahpspthpE...LENsKssKIuElNphFtu.chuNDsp.......KhthlsKIpuApslEElppIsV.t.hpp...........h-ptchhhplpphKspsIppIKstaG.lhphpl.ssELcpKI.....suplpsLhppVssscshcEllphp.-phLhsh.KhhY.............lchstcchhhoKD-AKcllsphs.ls-LhpapVpsV-hVplslVlsRpphsGulhpsGDpVplYsKss..ushh.tllspuYV.L........upIusSESpSpSoossspSSoooppS.pop.Ssu.tsph.sopp.p.p..soQotspp.SSShSYol.NLspIL+AhAAGKlst.scl+spLpsYGh+L.-lEcsTpl.thsEsTphLlIlcVPs-hVPcllphcsulllshsss	...................................................................................................................hh...lh.hhhhh...h.ha.........p.......hp..+..thttlptha....h.sp..............h..h..pl..u.s.pph.tl..............................thtth..p...h.................................................................................................................................................................................................................................................................................................................................................................s.........	0	8	18	34
+2177	PF04414	tRNA_deacylase	DUF516; 	D-aminoacyl-tRNA deacylase	Waterfield DI, Finn RD, Mistry J, Wood V	anon	COG1650	Family	Several aminoacyl-tRNA synthetases have the ability to transfer the D-isomer of their amino acid onto their cognate tRNA. D-aminoacyl-tRNA deacylases hydrolyse the ester bond between the polynucleotide and the D-amino acid, thereby preventing the accumulation of such mis-acylated and metabolically inactive tRNA molecules.	21.30	21.30	22.80	22.70	16.80	16.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.46	0.70	-5.21	34	183	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	168	4	114	186	85	216.70	29	69.66	CHANGED	lptDhh-......hhtcs-hllFlSRHpussshPsLTVHssGNhs.....s.sthGGpPtpluhusPthhssllcslpchs.........s....a-lohEATHHGPothshPshFVElGSoEp-WpcpcAscslAcullcslsp.tp..................pshlGhGGsHYAP+hoclslcschslGHllsKa.hs...........p.ls.........ppllppslp+s..ssch.shlDhKulputp+pplhphhcc.hulcllpp	............................h......t......thtss-hllFhS+Hsup.s.shPsLTsHssGNhs.........p.s.hGGcstpluhusPphhpshLptlpchss........p....s.................a-lshEATH.....H.G.......Po..........t..........hs.sP..........shF..lEIGSoEcpWp..spcAucslAc....ulhcshsttt.ttt................psllGhGGsHYu.s+aoclsh....c....s.p..hs..lG..Hllscatls....................t.ls....................tclltpuhpps...........ssph..shlDhcuhputp+ptlhphlcchslplh.h.....................................................	0	27	64	89
+2180	PF04378	RsmJ	DUF519;	Ribosomal RNA small subunit methyltransferase D, RsmJ	Kerrison ND	anon	COG2961	Domain	RsmJ is the tenth to be found of the ten methyltransferases required for full methylation of 16S ribosomal RNA (rRNA). It specifically methylates m(2)G1516. A strain of E.coli lacking RsmJ due to deletion of the rsmJ(yhiQ) gene is missing the methyl group at G1516 and exhibits a cold-sensitive phenotype.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.62	0.70	-5.38	8	1570	2012-10-10 17:06:42	2003-04-07 12:59:11	8	2	1530	1	321	1377	328	241.30	46	87.23	CHANGED	-KPFhhLDTHuGsGRYDLuu-cAc+TGEacpGIuRLhpp...sslPt.LpsYLcsI+phNhuss........l+aYPGSPhlA+pLLRsQDRhlhsELHPsDhslL+spFssDtpVpVcpsDGattl+ApLPPpE.....+RGLlLIDPPaEhpc.EYpclVpAlccuhpRassulhAIWYPIKsRpplccFh+uLcsosl+KlLpIELtV+PsospcsMsuSGMllINPPWsLEsphpslLPaLpppLu.s.sGphpl-Wl.s	.....................................................................-KPFhYlDTHAGAGtYpLs....u....-cA....p+TGEahpGIu..Rl...W.pp...........sc.L.P......s...t...LpsYl.ss.l+.p.h.....N.p..usp.................LR.aYPGSP.hl.A.c.p.L.....L......R.c......Q..D.......+.......lpLs...ELHPo.......Dasl.L.......+...s...p...F...............p.......c...............D............p......+...s........p...Vp...+...t..DGapt...L...+...A...hLP...P.hp........RRGLlLIDPPYEhK.s...D.Y.pt.VVpultcuaKRF.uTGs.YAlWYPl.....l......R................p.....p...........l....c....+.....h........h.ccL.......c........s.......s.....G.I.......+.....+...lLplEL......sV.....p.......P.........c....o.........-...............p......p.........GM.s...............uSGMlVlNPPWpL.......-pph.pslLPaLpptL..s.s....sG..phplpWl.................................................................................	1	70	169	245
+2181	PF04461	DUF520		Protein of unknown function (DUF520)	Waterfield DI, Finn RD	anon	COG1666	Family	Family of uncharacterised proteins.	22.00	22.00	23.10	22.20	20.70	19.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.09	0.71	-4.37	108	2052	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	2015	2	466	1129	1083	158.50	49	98.52	CHANGED	MPSFDIVS-lDhpElcNAV-pup+ElssRaDFKGoc.usl-lpcc..plpltu-s-apLcplhDlLpsKLsKRsls.h+sl-hs.pspptoGpps+Qplpl+pGI-p-hAKKIsKhIKDsKlK.VQAuIQGDplRVTGKKRDDLQtVhsLl+.pp..-ls.....hPLQFsNaR	.......MPSFDIVSElDhpElcNAV-pAs+ElsoRFDF+Gsc.A.slELs-c.....slplhu-uDFplpQlhDILpuKLlKRsls.spuL-hs.c...p...htSGcshp.pscLKpGI-s-sAKKIsKhIKDoKlK.VQApIQGDplRVTGKpRDDLQuVhAhlR...ts.....DLs........PlQFpNFR...........	0	133	293	392
+2182	PF04412	DUF521		Protein of unknown function (DUF521)	Waterfield DI, Finn RD	anon	COG1679	Family	Family of hypothetical proteins.	27.80	27.80	27.80	35.20	26.90	27.70	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.03	0.70	-5.92	42	289	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	256	0	143	298	337	382.20	33	88.27	CHANGED	hhLocp-cshLsG-tG.puhppAMcIllthuchhGAc+LlslspAHls....Gs..........Yp..GsuuL....cFlcchhp.huu+VpV........PTTlNshuh..Dh.p.hcphs...lstphscttt...clhcAahch.......Gs..csohTCsPYh..lts.hPph.....G-plAWuESsAVlaANSVLGARTN+cus..sLsuAlsG+sPhhGlHL-ENRpuslllcVcs..t.....csu.ashLGalsGchsss..plPllpGLps........sspDcLKALGAAhAooGusuhaHltGlTPE..A.shtssh.t...............-plslsts-ltpshppl....sssspplDlVslGsPHhShpEhcp....luphLcu+c...sshslhlssuRtlhppspc.GhlptlEphGspllsDT..ChllsPl.....hstttps.lhTNSGKhApYsPuhsGhslthGolpcClcu	.........h.Locc-ct..hLsGchG.cuhphAMcIllthuchhGAp+Lls....lsp.AHls.........Gs...............Yp...GpuuL....cFhcc.l.hp...hGu+Vp....V.................PTTlNs.huh..Dh.p.hctht.....lspp....htc....ttp.......clhcAahch..........Gs..psoaTCsPYh..ht.s.hPph.....G-plAWuESsAVsaANSVlGARTN+pus.hsLsuAlsG+sPhhGhHl-ENRpuplllclps..t...........sss.ashLGahlGchsss..plPhlpGltt........ssp-pLKshGAAhAooGusshaHl.GlTPEA....shtssht........h...........cplplstp-lppshcpl.....tssspplDhlslGsPHhSlpEh....pp.....luphlc......u+p.........psslhlssuptlhttsc.p..GhhptlcptGspll..sDT..C..hls.sPl............thps..lhTNSuKhApYhPuhh.GhpshhushtpClc.....................	0	42	84	111
+2184	PF04463	DUF523		Protein of unknown function (DUF523)	Waterfield DI, Finn RD	anon	COG1683	Family	Family of uncharacterised bacterial proteins.	22.70	22.70	22.70	23.20	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.99	0.71	-4.42	164	1833	2009-09-12 22:11:40	2003-04-07 12:59:11	7	10	1453	0	463	1420	90	141.80	33	63.83	CHANGED	lhlSuCLlGppVRYc..Guppt..sph.....lpphlpcth.hls..lCPEltsGLssPR.shclh..s............ssph.+lhs.ps.u.pDlTcphhphupptlpthp....slsshIlppcSPSCGhppl..Y........psshs...stthtG.pGl.huthlhcpt.hl.sE--h	..........lhlSuCLhGt..s...sRYD......Gspph.........ssh...........lpphl.p.p...t..h.......hls...lCPEl.t.s.GLssPR.sshcllt.....................t.sps.+l.hs..ps..u..pDVT......cphhphupptLp..phpt.......plss.....h.I.lp..s+SPSCGhppl...Y.............cu.phs......s.t.ptsGsGlhsthl.hcph.hl.sE--.............................................................	0	157	291	373
+2185	PF04411	DUF524		Protein of unknown function (DUF524)	Waterfield DI, Finn RD	anon	COG1700	Domain	This domain has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches [1].  The domain has two additional beta-strands inserted to the core fold after the first core alpha-helix.\	      It has been speculated that it could function as s methylation-dependent restriction [1].	22.10	22.10	22.40	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.17	0.71	-4.39	28	222	2012-10-11 20:44:43	2003-04-07 12:59:11	7	5	207	0	64	224	13	157.30	25	23.37	CHANGED	pLYEhWCalplhplLpph.....Ghphtppslhpspspsh.thslppsps....hhh..p..sshplpLtYpspht.t...........t..shsp+PDhsLplshtstt......hhhlhDAKYRl-sspct............................p-slspMHpYRD...Al..............ppsshuAalLaPGtps	..................................................pLYEhWsalplhplLpph.....................thph.hpp..s.l.h.p...hp.p.psh....hsslp.cups......hhhh.....p...psstplpLhaptph....t...............................t..sssp+PDhhLplpppspph................hphlaDAKY.Rlphs.tpt...............s.....................pcslppMH....p..YRD....Alh......................tt..hp+sshuualLaPhp.c...............................................	0	28	46	57
+2186	PF04379	DUF525		Protein of unknown function (DUF525)	Kerrison ND	anon	COG2967	Family	Members of this family include the bacterial protein ApaG and the C termini of some F-box proteins (Pfam:PF00646).  F-box proteins contain a carboxyl-terminal domain that interacts with protein substrates [1], so this family may be involved in protein-protein interaction.  The function of ApaG proteins is unknown, but mutations in the Salmonella typhimurium ApaG homologue corD gives a phenotype of low-level cobalt resistance and decreased magnesium efflux by effects on the CorA magnesium transport system [2].	19.30	19.30	19.60	23.30	18.80	18.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-9.91	0.72	-4.02	147	1678	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	1515	9	519	1070	541	89.30	48	52.06	CHANGED	l........s-pSsPpps+..asFuYslsIp........Npupp.s.....sQLl........oR+WhIT.DusG.chpEVcGpGVVGcQPhlpPG-.sapYoSGssLsTPsGsMpGpYpMhs...cs	..........................................................l..tQSsP-.p.p+..YsFAYslTIc..............NhGpt...s...........VQLl........uRaWlIT.....sus.........G....+.p..EV......p...G.cGV.VGpQPlls.........PG-..p....apYTSGss....lp........T.......P.......h.G.s.MpGpYpMlsc.s....................	0	150	289	406
+2187	PF04380	BMFP	DUF526;	Membrane fusogenic activity	Kerrison ND	anon	COG2960	Family	BMFP consists of two structural domains, a coiled-coil C-terminal domain via which the protein self-associates as a trimer, and an N-terminal domain disordered at neutral pH but adopting an amphipathic alpha-helical structure in the presence of phospholipid vesicles, high ionic strength, acidic pH or SDS. BMFP interacts with phospholipid vesicles though the predicted amphipathic alpha-helix induced in the N-terminal half of the protein and promotes aggregation and fusion of vesicles in vitro.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.77	0.72	-3.84	131	1484	2009-10-26 17:57:44	2003-04-07 12:59:11	8	3	1473	0	318	838	803	78.10	44	82.37	CHANGED	M.ss.chl-.......-lucphspshsss...puhtc-...lEpph+shlppths+lDLVoREEFDsQpplLt+sRp..........+lcsLEsRlutLEsp	....................Mhss.+hl-.......plA+plp-uhstu...hpphucD...lEcplR.p.hLQutLs+..LDLVoREEFDVQspVLlRTRp.......KLst.LEpRlucLEst..............	0	79	171	241
+2188	PF04384	Fe-S_assembly	DUF528;	Iron-sulphur cluster assembly	Kerrison ND, Eberhardt R	anon	COG2975	Family	This family of proteins is likely to be involved in the assembly of iron-sulphur clusters. It may function as an adaptor protein. In Escherichia coli Swiss:P0C0L9 forms part of the isc operon, which encodes genes involved in iron-sulphur cluster assembly. Its structure is entirely alpha helical, and it contains a modified wing-helix structure, usually found in DNA-binding proteins. It binds to Fe2+ and Fe3+ ions and to the cysteine desulfurase IscS, the same surface of the protein is involved in both binding to iron and to IscS [1,2].	25.00	25.00	26.00	25.40	20.60	18.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.90	0.72	-3.61	61	1135	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1120	2	184	434	221	63.60	63	95.87	CHANGED	hKWsDsp-IAhtLh-paP-.lDPts...lRFTDL+pWVhsL...ssF-DDPp+ssEKILEAIQhsWl-Eh-	................lKWTDoR-IuEsLYDtaPD..lDPKT...VRFTDLHpWIs-L...-DFDDDPptS.NEKILEAIl.hsWlDEuE..................	0	40	86	134
+2189	PF04385	FAINT	DUF529; 	Domain of unknown function, DUF529	Mifsud W, Yeats C	anon	Yeats C	Family	This family represents a repeated region found in several Theileria parva proteins. The repeat is normally about 70 residues long and contains a conserved aromatic  residue in the middle. 	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.31	0.72	-4.13	64	1072	2009-09-11 15:51:37	2003-04-07 12:59:11	10	26	6	0	961	1070	0	76.20	15	28.74	CHANGED	hlcl.....tshppsphhhhp............hhhhhhthp.pshphpplhh...........psphlWptpsspphhhhhhhhhptt......hhlhlhhsptt	....................................................pp...ht.............ttthhpaph+.suhphpKlhh.......................ssp.hlWcp.sc...s.sp.hs.hh.h.h.ht..........hhhh.......h.............................	1	2	558	558
+2190	PF04409	DUF530		Protein of unknown function (DUF530)	Waterfield DI, Finn RD	anon	COG1771	Family	Family of hypothetical archaeal proteins.	20.10	20.10	20.30	104.10	19.00	19.80	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.58	0.70	-6.40	7	60	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	39	0	47	64	5	306.90	25	99.99	CHANGED	.ooptLIspsN+hLDsIs.c..hschhcDhDshh............lhhTLcsNLc.Lp-LcEchEhR.G.tuPh.sltch+utts................HhpalhRKtp.+phhLERl+SAIsuHKIALuhLpt.h.hph.pst.p.p..p.p......................chch..p..slGRlEIlPaLshuG-hhclhuphs..shcuaKcIhshh+pEGhsthcShplplchhEp..G+..hK+h+l-.s.DsDhEt.LRK+aGpphRhcllphh+o+ssLINs+YshcsLALAYhshs......................................................................ccGtcL..........................luhDlF+YYhhTS.c-Rpp.ss.FPul+sslDspa....ol.sls.+chhDhh.s.hp...........hl.hKh-lEcpLsKh+hcls.h...hlGGlhLYhhusas.pcss-lhtl-lEElhc..hhhhlpslhpllhsc..-hpKhEKa.hP+o-KAKpFLpLLpG	............................................................ppp.Lltp.pchLptlt...........t.hp.p.................................l...Lppplp.Lpphcpphph..t...P...h.phttt..................a.phhhhhhp.+h..L-Rl+.AlsuH+hAlu.ltt..................................................t.hphpl...LshsGshh.hh.p.s..hhpta+.hhthhp.pt..................hs.hpthph.l.hhpt..s+..h++.pl-.....shEt.l+ppaGpth.hp.hph.hphs.llsspYshp.LuluY..h............................................................................................................h..DlhhaYhhpo.pcRtt..s.aP.lh.s.p.t.......h.th...t..th.....................Kh.hEp.h.thp..hp......hGuh.l......hp..p..th.th..ppl.c....................htphpph.h.ppt+s+pFLthl..t......	1	6	11	31
+2191	PF04407	DUF531		Protein of unknown function (DUF531)	Waterfield DI, Finn RD	anon	COG1772	Family	Family of hypothetical archaeal proteins.	25.00	25.00	80.50	79.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.87	0.71	-4.38	9	38	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	38	0	33	41	9	170.90	53	89.30	CHANGED	MLTlGLYNTYDpp+lHEAHhRAIARAAPlsYAFsF+LALhsFPac...h.sscElsEhVscpTTIG-uG+YLhtLt-pN+halhDhPp+GFPsQFGplVuTTSKP-ccKslsPh-lAchhL+s+ShhllIGLGR+GLPKElachucYHLDIT.s+tlSLETCTAIGuIsAhIhslhcsh	..MlTLuLYNTYD+pKlHEAHhRAIARAAPICYAFsFpLALhsFPhc.........t.p..-ls-hls.pcTTIG-uGcYLtcLh-pN+FallDhP.hGFPsQF.GpsVATTSKP-ccKtIoPh-lAchhL+t+ShhlLlGLGRHGLPK-lhKhu+YHLDIT.GKslSLETCTAIGuIPApItTlhc.h....	0	6	12	24
+2192	PF04391	DUF533		Protein of unknown function (DUF533)	Kerrison ND	anon	COG2979	Family	Some family members may be secreted or integral membrane proteins.	29.60	29.60	29.80	30.40	29.20	28.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.09	0.71	-4.92	61	974	2012-10-03 21:00:09	2003-04-07 12:59:11	7	5	942	0	139	548	37	188.60	44	85.52	CHANGED	uuhlss........husG............uLs.....GGlhGhLlGs+pup....phuusuhthGGh.AulGsLAYpAYpsa..psp...ps...........sssssspshstsss...................tt-pputhlL+AMIuAAKADG+IDppE+ptI.tplschshDsctppalpppLppPlDsstlApts.ps.phAsElYhAShlsl-.-shtE+uYLspLAptLsLssslspplEppls	...................................................................................................ts.sth......LssG.......AL..GGLAGlLlusKouR..........KhGssA..LhlG.Gu.As...h.Gslhap........tYpch.......p...s.................................stQspPQhsspsss.....................................................h-p+oppLlhAhlh............AAKSDGHIDscERA...tI-...ppLcEu..Gl...-...cpucshlEptlc....pPLDPp.cL.Apul.psEEpAh.......ElYhhS.phAID.....D.........pFM...ERuY....LstLucAL+lspslp-tIEpsl.p......................	0	31	61	102
+2193	PF04392	ABC_sub_bind	DUF534; 	ABC transporter substrate binding protein	Kerrison ND, Mistry J	anon	COG2984	Family	This family contains many hypothetical proteins and some ABC transporter substrate binding proteins.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.49	0.70	-5.46	9	2266	2012-10-02 13:57:41	2003-04-07 12:59:11	7	34	1502	3	510	1839	143	277.50	32	82.31	CHANGED	cIulhthlpHsuLstthpGhp-uLp-hGhpp.p..hhphhNApss.spstphu+pLhscpsclllsIuTPsAQtlhuthcs..lPlVhuAVosPlutpLs.shcpsttNlTGVs..Dt.slppplphh+tlhPss+slslhYsPuEssshshhccl+thAcptGlpVlphslssos-lspshpshsp+ssulahshsshlssuhsu..llpsupptKIPlhsussuhVccGuh.AAhulshpphGhpsuphlhclLcGpcst-lssphssp....phhlNcpshppLGIplscshhspusphc	.......................................................................................................................................................................................................plulhphlpHsu..LDth.hcGh.....-sL.tct...Gapp...c..plc.l.......c....h....p..N.A..p.....G.....-....p......u......p....htp.hu.....p.p..h..s.s.p....p..s.D..ll.l.u.I...A..TP..u...A.Q......u..l.........s.........s...s........o.......p........s.............l....P.l..lhsA.V.T.D.P.....lu....A......tL...V.p...s...h.....c.p.P....G...s....N.lTG..sS.......D..t..s..P...lp.pp.lcL...l.+c.lh..P.s.s...K.....p...lGl..l...Y..s...s.u..E......s..N..S...h..s..pl..c.p.h.+..p...h...s...p..c..t..G..l..p...l..h.......p....h........s........l.......s..........s..........o.........s.......-.......l....t........p........s.......s.........p........s............h....s...s...c........l.....D.....s...l....a.....l.....P......s...D.N....s.........l...s...S.....u.....hps.........l..sp...s..u.......p...p.....s..Kl.......Pl.h.s......u..s.s.s.h.....V...c...p.G...u...l...A.u..h..u.l..s..h.h.p.l.G.hp...T.Gc.h.ss.c.l.....L.c.G.c.c.P.u.s.h.sl.phh.pp.....chhlNpch.AppLG..lslspthhtt.....h....................................................................	0	178	346	426
+2194	PF04393	DUF535		Protein of unknown function (DUF535)	Kerrison ND	anon	COG2990	Family	Family member Shigella flexneri VirK (Swiss:Q99QA5) is a virulence protein required for the expression, or correct membrane localisation of IcsA  (VirG) on the bacterial cell surface [1], [2]. This family also includes Pasteurella haemolytica lapB (Swiss:P32181),  which is thought to be membrane-associated.	19.10	19.10	19.10	21.40	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.84	0.70	-5.50	34	1261	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	911	0	96	664	6	271.70	36	90.85	CHANGED	hhstps.....hhpphpp+hKahhRsllhhtphpphhphlsp...shhpslhpppPphst+lh+PYlspshstppRlpsltpHaphhppthstphhp.lhppt.slpLsplp...tppaslhLshssths+EG-hsL.Lpspp.tphlhploFolh.........sppsLhIGulQGsss....-psp-hl+phTKshHGLRPKpLllEshphLApthslcplluVupcsHlapph+a......ppclhsDYDphWpEhGGp..spsaap.LPlphtRKsl--IsSKKRuhYR+RYthLDplppslpptL	..............................................................t........thhpctpaRh+FhlRsll.hsthsh.phhptLsp...PphpsLls.p.p.Pplsh+lpRPYls.........tshs.tpp+lculh.Hathlpp............h............hs...........t..c..h............p.....hls..p...slpLuc.........lp.sK.......ss-pa..sl..pLs.h.hshc.+EG-holhlp..ssc....tsLuploFol..s...h.p......sppshhIGGLQGsph......chspphIppATKsCHGLhPKcLlhEAhphhApthpl-pll.AV.opcsHlapphRY.h.pK..cpph.hAsYssFWpslGG.....p...p......t.p...aac..LPhp.lsRKslt-IsSKKRupYR+RYthLDslptphst......................	0	11	32	65
+2195	PF04394	DUF536		Protein of unknown function, DUF536	Mifsud W	anon	Pfam-B_2107 (release 7.3)	Family	This family aligns the C-terminal region from several bacterial proteins of unknown function that may be involved in a theta-type replication mechanism.	20.70	20.70	21.60	21.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.53	0.72	-4.22	29	746	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	588	0	44	358	4	47.70	44	25.93	CHANGED	hccQlppcc...........pplpch.......ppLLDQQQpLsLpspchlEc........hKs	..............................hccQlchKD...........pQIsEt..............sK.LDQQQpLsLpuhKchEpLc.pL-p.t+.......................	0	6	14	32
+2196	PF04398	DUF538		Protein of unknown function, DUF538	Mifsud W	anon	Pfam-B_2637 (release 7.3)	Family	This family consists of several plant proteins of unknown function.	25.00	25.00	25.00	25.10	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.22	0.72	-3.80	58	600	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	46	1	341	552	1	111.40	29	68.11	CHANGED	osh-lLcpashPhGLLPpsl.p.sYshspsoGphp.lhhs......s.........s..Cphphps....hp..lpY.........ssplo...........................GhlspG................+lsslpGlpsK.......lhlWlslsclth....susplhFps..Gshs....cshshssFpps	.........................h-lLpchGLPtGLL.Phss..p.pashscsoGhhh.lhhp.....p..........s.Cphpacs....ht..lpY.........ssplo...........................GhlppG................+lpplpGlcsKt......lhlW.lslspltl......susplhFps..usls....csashssFp.........................................	0	30	189	274
+2197	PF04400	DUF539		Protein of unknown function (DUF539)	Kerrison ND	anon	COG2991	Family	Putative periplasmic protein.	20.80	20.80	21.00	20.80	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.62	0.72	-4.47	37	588	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	495	0	111	320	178	45.40	45	59.21	CHANGED	hIhp+KsIpGSCGGluulGl-KtCD.C...cpsCDpppc+.hpttt..tp	...aIhp+KslpGSCGGLu.u.l....G.l.-K.sCs..C.............scPC.Dscp++hspttt...p.........................	0	25	53	87
+2198	PF01877	RNA_binding	DUF54;	RNA binding	Enright A, Ouzounis C, Bateman A, Eberhardt R	anon	Enright A	Family	PH1010 Swiss:O58738 is composed of five alpha-helices (1-5) and eight beta-strands (1-8) with the following topology: beta-1, alpha-1, beta-2, beta-3, alpha-2, alpha-3, beta-4, beta-5, alpha-4, beta-6, alpha-5, beta-7, beta-8. The first six beta-strands (1-6) form a slightly twisted antiparallel beta-sheet and face five alpha-helices on one side. The last two beta-strands form an antiparallel beta-sheet in the C-terminus. PH1010 forms a characteristic homodimer structure in the crystal.\	      Dimerisation of the molecule is crucial for function. The structure resembles that of some ribosomal proteins such as the 50S ribosomal protein L5 [1]. Although the structure resembles that of the RRM-type RNA-binding domain of the ribosomal L5 protein, the residues involved in RNA-binding in the L5 protein are not conserved in this family [2]. Despite this, these proteins bind to double-stranded RNA in a non-sequence specific manner [3].	22.90	22.90	23.60	27.50	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.43	0.71	-4.10	52	277	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	140	17	189	274	118	115.90	25	77.86	CHANGED	pplplpshlasTEDp-KVhcAlpslh............chphphpptcGaaup.....p.hlptt.sspcsLcplpchlcppcl..cth+s.tlpcplp..ssphhh+lsKQsAa.hGplphsp.ss.....ssIplplchc	..........plplpshlasTED.cKVhcAlpslh............shchp.h.ppppGaas.......h.lptt..pspcslcpltchlcppcl..cthps..lpcplp..ssplhh+lcKQsAa.hGplshsc.ss......ssIplplch............................	0	47	104	149
+2200	PF04402	SIMPL	DUF541; 	Protein of unknown function (DUF541)	Kerrison ND	anon	COG2968	Family	Members of this family have so far been found in bacteria and mouse SwissProt or TrEMBL entries.  However possible family members have also been identified in translated rat (Genbank:AW144450) and human (Genbank:AI478629) ESTs. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase).  SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity [1]. Separate experiments demonstrate that a mouse family member (named LaXp180) binds the Listeria monocytogenes surface protein ActA, which is a virulence factor that induces actin polymerisation. It may also bind stathmin, a protein involved in signal transduction and in the regulation of microtubule dynamics [2]. In bacteria its function is unknown, but it is thought to be located in the periplasm or outer membrane.	24.90	24.90	25.30	25.30	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.12	0.70	-11.52	0.70	-4.47	156	2985	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	2441	0	788	2172	443	200.80	20	84.19	CHANGED	lsVsGpuphpstPDhstlslslps..pspssspA.......hpp.s..spphppllstl......p...phu.......lt...p...ps.lp.....s......sshsl.p.............Ppa......p...........................................thtG.Y..........psspp.lp..lphp.cl....sphup......llsthhs...tsh................s..pl....sslpaplsctpphp..pcshppAlpsA+p+ApthApsh....G.hplsplhpl...............p.sstss.................hhthth.ttss..........sshpsuphplsssV.....sssapl	....................................................................................lslsGpuphc...sssDhsplslplps...........pupsss.su.............tpp.s.....spphsphlshL....c......................ptG....................................ls......c...c-........lp.........s...ushsh..p................................PpY..........pa.p.....................................tpptlpG..Y.......................................pusps..lp..lphc...sl.......splsp..............ll...st...hhp........tGh..............................................s...pl......psl..p..a..s..l..sp.....sthc..scshppAlpsApppApplApuh.....s..tpLG.t.l.h.pl.........phustss...............................ht.h..th.ht......................sh.p.sphphpsplsssat.............................................................	1	250	495	659
+2201	PF04418	DUF543		Domain of unknown function (DUF543)	Bateman A, Wood V	anon	Wood V	Domain	This family of short eukaryotic proteins has no known function. Most of the members of this family are only 80 amino acid residues long.  However the Arabidopsis homologue is over 300 residues long.  The presumed domain contains a conserved amino terminal cysteine and a conserved motif GXGXGXG in the carboxy terminal half that may be functionally important.	21.30	21.30	23.20	22.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.67	0.72	-4.02	35	301	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	235	0	198	280	0	72.70	36	72.16	CHANGED	Moppsp.......................................plscKWDpslussllKsuhGhusGllsSlLhF+R...RsaPlhhGsGhGlGhuYs-scthFp	.......................................................................scs...........................lscKWD+ClushllKsuhGhuhGllhSllhF+R......................RsaPl....hlGsGhGlGhAYspCptpFp........	0	66	107	168
+2202	PF04424	DUF544		Protein of unknown function (DUF544)     	Kerrison ND	anon	DOMO:DM04041;	Family	Eukaryotic protein of unknown function.	20.80	20.80	23.00	21.90	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.61	0.71	-4.30	8	377	2012-10-02 14:22:40	2003-04-07 12:59:11	8	9	242	0	265	379	5	124.40	30	22.46	CHANGED	sNlLlLpssls........LssppphlTt--LhphLsDhhlp.ts...........shppNhs-shslLs+LtsGLsVNl+Fs...............ulpsFEaTPEhuIFcLlslsLYHGWllDPp.s-.hsculushSYspLhctlsss	.............................................................................hNhLhLp.php........................L.s....p...tp..lohppLhphlu.....-hl..lphpst...................................sh.p..tsls-hhslLspLpTGL.sVNs+Fs............................GhtsF......E...h....T..s........E...htl.FcLhsIPLhHGWllDPps..sp....hh....pt.l..s..p..h..SYsph.phl.................................	0	79	132	200
+2203	PF04440	Dysbindin	DUF546; 	Dysbindin (Dystrobrevin binding protein 1)	Finn RD, Moxon SJ	anon	Pfam-B_3919 (release 7.5)	Family	Dysbindin is an evolutionary conserved 40-kDa coiled-coil-containing protein that binds to alpha- and beta-dystrobrevin in muscle and brain. Dystrophin and alpha-dystrobrevin are co-immunoprecipitated with dysbindin, indicating that dysbindin is DPC-associated in muscle. Dysbindin co-localises with alpha-dystrobrevin at the sarcolemma and is up-regulated in dystrophin-deficient muscle. In the brain, dysbindin is found primarily in axon bundles and especially in certain axon terminals, notably mossy fibre synaptic terminals in the cerebellum and hippocampus. Dysbindin may have implications for the molecular pathology of Duchenne muscular dystrophy and may provide an alternative route for anchoring dystrobrevin and the DPC to the muscle membrane [1]. Genetic variation in the  human dysbindin gene is also thought to be associated with Schizophrenia [2].	25.00	25.00	30.50	25.70	20.90	17.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.03	0.71	-4.45	7	190	2009-09-10 17:06:14	2003-04-07 12:59:11	11	2	41	0	87	168	0	142.30	37	66.55	CHANGED	tths....csscsPpstl..ssplplptcpth..ts.ptEtEhsls...suhLplsE.+RpPluSlSShEVphDLLD.sELhDMSDQEhA-VFhsS--E.stspSPs................s.p...h.+husLcSsShsp.opsppspEcps.sDs-......ss..t.....l-	................................s...ctpcs.chth....sQQh+L+ERQKaFE-shQt-hE.hls...suaLQls-.RR..p.............PlGShSS..MEVNVDhLEQh-LhDhSDQEuhDVFLsSs..sEps.ss.SPs........................s.t.....hs.p....s..s.pSssh.s...psops..p.tttp.p..........................t...............................................................	0	3	10	37
+2204	PF04445	SAM_MT	DUF548;	Putative SAM-dependent methyltransferase	Kerrison ND	anon	DOMO:DM04150;	Family	This is a family of putative SAM-dependent methyltransferases.	26.00	26.00	26.10	26.00	25.80	25.50	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.55	0.70	-5.21	7	1454	2012-10-10 17:06:42	2003-04-07 12:59:11	8	3	1428	5	251	988	353	223.20	46	88.57	CHANGED	tclhtltstasLtpsp-sshALlhscp.....pLELRplDEsp.GulhVDFVuGAhAHRRKFGGG+GEslAKAVGlpsuhhPsVlDATAGLGRDAFVLASlGCcVphlERHPlVAsLLpDGLpRAhtDs-IGthlpp+lpLlhssuhstLp......shspPDVVYLDPMYPH...+pKSALVKKEMRlFppLVGsDhDAcsLLcsAhpLApKRVVVKRPcYA.hLusppPsauhpTKspRFDIYhst	......................................................................tt...........l...t..st.p.s...h.sLl.hs.p.....pLpLpp..h...s-s.c..G.slhVDFlsG.uhuH.R.R.K..F..G.G.G+.G..-.slAKA.lGlct.s...h..h....P..sVlDATAGLGRDAFV..L..A.S...l....G..........C....+..Vph..l..ERs.PVVAAL.L-DGLp...........R.........u....h.....t....D.......s......E.I.......s.......s....h.....l.....t.....cRl.p.Llau.sSlsh.Ls..................sh.s.sp.P-VVYL.DPM..F..PH.......+...p.K.S.AL...VK...KEMR...lFpsL.......V............G................s........D..h..D...A...D...s..LLps.A.h....tl.A..p..K......RVVVK.RP.chAs.L...u....s.h.......ts.s.sl..s..K.spR..FDlYh.p.......................................................	0	81	135	196
+2205	PF04446	Thg1	DUF549; 	tRNAHis guanylyltransferase	Anantharaman V	anon	Manual	Domain	The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His [1]. The catalytic domain Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases,  diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system [2]. Thg1 possesses an active site with three  acidic residues that chelate Mg++ cations [2]. Thg1 catalyzes  polymerization similar to the 5'-3' polymerases [2][3].	26.60	26.60	32.90	26.60	24.40	23.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-11.01	0.71	-4.54	100	440	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	356	8	291	450	19	126.10	39	45.52	CHANGED	+hchl.+paEppsp...llPssalVlRlDG+uF++Focp.apFpKP...pDt+slplMspsApsl.hpphs.clsluYupSDEhShlhcc..sssh..............asRRtpKlsShlsShhoupashhatphh.p........h................................s..PsFDuRslhhP	......................................h.hcYV.+p.FEtts.p...llspsalVlRlDG+sF+.+.....Focp.apFpKP...N.Dp+uLpLM.spsApsl.hpc...........ht....-....lslAYGpSDEa...SFla+c...pssh.............................................apRR...s..sKlhohlsShFousYshhWtpaF.p............p..L.h................................................s..PsFDuRsVhYP................................................	0	100	174	238
+2206	PF01878	EVE	DUF55;	EVE domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	This domain was formerly known as DUF55.  Crystal structures have shown that this domain is part of the PUA superfamily. This domain has been named EVE and is thought to be RNA-binding [3].	21.10	20.60	21.10	20.60	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.06	0.71	-4.17	140	1582	2012-10-02 17:37:24	2003-04-07 12:59:11	13	19	1431	13	568	1316	1573	137.80	30	64.70	CHANGED	sY...WLhK......oEPp..........auhpph...ppptp..shWcGVRNapARN..hh+.pMchGDhshFYHSs.....tpt...ulsGlscV.s..cpsasDsoth.......s.t..........ps+WhhV-lchh.pphspslsLppl.....+........tp..t............Lpch.sll+pu..R............LSlhPVspccaphIh.ph	..............................................taWLhKoEPtt..............auhpp.....ttptt..t.WsGlR..N...ap..ARN.......hh+.pMchGDtshFYHSs........................ct.......ul.lGlsc..V.s..ppsasDsst..........stt...............tspahh..V-Vpah..cph.s..p.slsL.spl+.....................tp..sp.............................L.psh..llpps..R...........LSltPVop.spaphIhp.....................................................	0	170	336	459
+2207	PF04447	DUF550		Protein of unknown function (DUF550)	Kerrison ND	anon	DOMO:DM04177;	Family	This family is found in a range of Proteobacteria and a few P-22 dsDNA virus particles. The function is currently not known.	21.40	21.40	21.40	21.40	20.90	21.00	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.38	0.72	-4.40	10	150	2012-10-01 21:36:44	2003-04-07 12:59:11	7	3	138	0	8	97	13	98.30	67	44.14	CHANGED	phhc+HA-WS-+TFG.slpssGsLcHLuKEhlEltAsPsDlsEWADlhhLhaDutpRuGlosppIscAlhsKhslNcuRpWP-.+su-PchtI+cpsssss	.....................................IR+EHAcWSDuTFG...sVGPIGPLKHLSKEALEAAAE..P...DDL....S....E..WADMQFLLWDAQRRAGIS.DupITsAMc-KLcINhcRQWPE.PKDGEPRLHIKE.sss.PV.........................	1	3	5	7
+2208	PF04448	DUF551		Protein of unknown function (DUF551)   	Kerrison ND	anon	DOMO:DM04177;	Family	This family represents the carboxy terminus of a protein of unknown  function, found in dsDNA viruses with no RNA stage, including  bacteriophages lambda and P22, and also in some Escherichia coli prophages.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.78	0.72	-3.22	26	815	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	445	0	22	522	9	66.40	34	34.52	CHANGED	GWISCoERhP-..psp....VLlh..........t...hssthtsthhshhhssspa...............................thppsTHWMPLPcPPp	....................................................................................................................................................GWISCSERMP-.........psp.......tVLlh.................tt...hshhhss....t.h......h.s.ss.t..ss.s.ph...............................sth.ppsTHWM...PLPEPPQ............................................	0	2	7	11
+2209	PF04472	DUF552		Protein of unknown function (DUF552)	Waterfield DI, Finn RD	anon	COG1799	Family	Family of uncharacterised proteins.	21.10	21.10	23.20	22.60	20.60	18.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.02	0.72	-4.06	120	2218	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	2038	2	449	1368	357	73.10	35	43.08	CHANGED	lhlhcPpsa.s-spp.ls...cplcst.psVllNlpphcpcp...ApR.llDFluGssaulsGclp+l...upp.lalloPssVcls	.................lslhcP+sY..s...-App.Iu...-p.L+ss.csV.llNl.p.phccsp.........A+R.llDFluGssaulsGslp+V......usp..lFLhoPsNVcl............	0	149	312	401
+2210	PF04473	DUF553		Transglutaminase-like domain	Waterfield DI, Finn RD, Bateman A	anon	COG1800	Domain	This family of uncharacterised archaeal proteins are related to Transglutaminase-like domains. This family has previously been called DUF553 and UPF0252.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.11	0.71	-4.95	14	69	2012-10-10 12:56:15	2003-04-07 12:59:11	7	5	50	0	45	689	23	149.60	21	35.45	CHANGED	pclpsluppL....pGsspt-ohWNlLcW.ccNlcYDasKuphh....................................................................................h..Ip.............................................oPpEhlth+cGlCsDYAlLTuulLLs.NhsshYllphphpps..h.....HAAsAlplsGshalLDQ+.P.hchssYl........phhc.cshhIpslshY	.............................................................................................................................................................................h...t..t..s...pthhplh.pW.p..pslp..Y...shp+sp............................................................................................................................................................................................................................................hp...........................................................sP.h-sl.phppGlCpDYAlLTuul..Llp.................sh..s.......s..hY..l..........l...t...h...p.....h...p....s.p....t..........Hsssul..p.l.s..u....phal.lD..pp..s.h.....htpah.......................................................................	0	12	22	33
+2211	PF04474	DUF554		Protein of unknown function (DUF554)	Waterfield DI, Finn RD	anon	COG1811	Family	Family of uncharacterised prokaryotic proteins.  Multiple predicted transmembrane regions suggest that the region is membrane associated. 	21.00	21.00	22.20	22.10	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.24	0.70	-5.20	64	1327	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1217	0	230	848	239	223.00	39	97.03	CHANGED	hhGollNshullhGullGhhltpplP-+h+pslhpulGLsslhlGlphshps............cshlllllSLllGullGEhlplEctlsplGphlc...............................................................pst.psphscGFVouoLLFClGuMuIlGulpsGLsGDhslLhsKolLDGhoullhAuohGlGVhhSAlPlhlhQGulsLhAshlpshlsssh..........ls-hoAsGGlLIluIGlslL....tl..+cl+VuNhLPALllshhlshlh	..............h.lGshlNusAlllGullGsLlsp+lP........ERh+sohhphhGLsslslGI.hslcs...................tNh.shlluhllGulIGEhhtLEctlsphssthp........p.......+..............................................................................tp.p.s..tcpsFhpuaVshhlLFCsuuhGIhGAhppGhoGDsoILhsKShLDhFoAhIFAsoLGluVsh.ulP.lllhQhsl.s.hhAshI.h.s.lhos.sh..........hs-hoAlGGlLllAsGLp.lh......uI.......K.hh.VsNhLPALllshslshh...................	0	97	162	198
+2212	PF04475	DUF555		Protein of unknown function (DUF555)	Waterfield DI	anon	COG1885	Family	Family of uncharacterised, hypothetical archaeal proteins. 	25.00	25.00	41.50	41.20	22.30	21.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.27	0.72	-4.01	14	106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	80	0	72	99	1	102.40	53	80.82	CHANGED	ssYhVsLEAAWlV+DVcolDDAIulAISEAGK+LN..sL-aV-l-lGhphCPtCGE.h-ushlVAsTALVGLlLpMKVFNAEStEHAtRIAKuhIG+AL+cVP	....sYhVslEAAalV+DV-osDDAIslAlScsGKtLN..cL-YVEl-lGhotCPtCGE.h-sAFlsAcTALVGLhL-M+VFNAESpEHApRIAKupIGpAL+clP.	0	10	44	62
+2213	PF04476	DUF556		Protein of unknown function (DUF556)	Waterfield DI, Finn RD	anon	COG1891	Family	Family of uncharacterised, hypothetical prokaryotic proteins.	21.20	21.20	21.20	22.00	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.55	0.70	-5.14	4	172	2012-10-03 05:58:16	2003-04-07 12:59:11	8	5	145	0	104	180	67	193.90	35	90.49	CHANGED	MlLLlSPhsVEEAlEAIcGG..ADIlDVKNPsEGSLGANFPWVIRcIREhsPcD.h.VSATlGDVPYKPGTlSLAAlGAsVSGADYIKVGLYGs+Nh-pAlElM+sVVRAVKDhcsstlVVAAGYADAaRlGuVpPLtlPclAAcuGADlAMLDTAIKDGpoLFDahshEhltpFVchA+spGLhsALAGSlsppHltsL+ElGsDIVGVRGAsCcGGDRNsGRIcR-LVtcL+Ehhc	................................................LLhSstshpEAh.shtuu..sDIlDlKpPtcGuLG....A.............s.sl.+.tl....ht...h...s..st......p.....h....lSAslGD.h.s.hc..P..ss.hs..Ashs........ss.s..s.G.....scYlKlGlh..shts.tts..hphh..tth..t.h..........hh.l........lsshauD.h..........s.h.l.........thhtpuG.h...sssMlDTuhKc.G.ps....Lh-ahs.ptLtpFlp.s+phGLhsuLAGSlpht-lshLt..t..lssDhlGhRGAlCtstcRst.tlp.phVtthht..........................	0	29	70	91
+2215	PF04452	Methyltrans_RNA	DUF558; 	RNA methyltransferase	Kerrison ND, Basturea G, Mistry J	anon	DOMO:DM04256;	Family	RNA methyltransferases modify nucleotides during ribosomal RNA maturation in a site-specific manner.  The Escherichia coli member is specific for U1498 methylation [1][2].	21.00	21.00	21.10	23.80	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.30	0.70	-5.23	96	4583	2012-10-01 22:53:19	2003-04-07 12:59:11	9	6	4226	22	1026	3326	2801	217.90	29	90.03	CHANGED	ltlss.cps+HlhpVhRlp.G-plhlhs.sputtahupltphsccph..hplh........cthphssc.s.......lsls.ulsKs.c+h-hhlpKusELGssplhPhhscRo..p....pphtp+hpRhpplshpAsEQutRshlPplp.sh.shpphl.pphspt.h........llhapctt.t.tth.thttth................plhlllGPEGGaospElphhpp.tGhpslsLGsR.ILRsETAulsAluhlph	....................................................h..lss.-pspHlhpVhRhpsG.-plhLh........s.....s............s......s.......t........ha.h..up...l..t..p.h..s....c..c....p...l.....lc.lh...........................................cth..p.ts.tc...Php..................lplspuls+u.-+hEhhlQKusEL.Glsplhsl.ucRsh....s....+h......pt....c......+............htK+hp+.ap+I.shtAsEQ.st....Rsh.lPpl..p......hh...shp...p...hh....tp....hs.pt.t......................llha.t.c.s.t.p..p...t.p.hst..hp.....................................................plhlllGPEGGh.o.s.pEl.phh.........p.......p....t.......s.....h.pslsL.G.PR.lL.RoETAslsAluslp.........................................	0	362	687	881
+2216	PF04480	DUF559		Protein of unknown function (DUF559)	Kerrison ND	anon	DOMO:DM04310;	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.45	0.72	-4.40	8	1749	2012-10-11 20:44:43	2003-04-07 12:59:11	7	59	1173	3	463	1520	202	98.00	26	32.61	CHANGED	pchptpARcLRpstThsE+sLWphLRs+RLsGaKFRRQtPlGsYIVDFsCtpsKLIVELDGuQHstp..csYDApRTpaLputGasVLRFhN-EVhps.-sVL-pILptLp	......................................................................................t...................p..hh....h.....tt.....................h.php..p..ph..l........s.....t........a.....h...l.......D...h..h.....h............p....t....+......l....l..l....ElD.....G..s.....p....H...t...ps.............ht.....h...D.....t.....pR.......ss.hL....p..s..t..G..a.p.Vl.Rh.hs.pcl..h..pp..c.tVlptlht...h.......................	0	130	318	395
+2217	PF04575	DUF560		Protein of unknown function (DUF560)	Waterfield DI, Finn RD	anon	Pfam-B_4010 (release 7.5)	Family	Family of hypothetical bacterial proteins. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.80	0.70	-5.18	22	575	2012-10-03 17:14:36	2003-04-07 12:59:11	8	16	290	0	79	541	30	264.50	25	62.17	CHANGED	WpassuhsYhp-cNlNsuscptph..........ttsh..stPpsApGlsaphuhpKcasltssaahphphsstG+hYWcN+c..Ys-hosRhthGhuYpsu+pplslhPFhEppaa...........utcpYspst......GlplphshhlospWphusshEhtpppY..hcc...pchsGshphhSsoLhah.ssppaaahGhDahcpps.ps......cspSapppulRhGWuQ-Wsh..GlooplshuhupRpYcshshhh.............shpR+DcpassslolW+RshaahGlTP+LsapapKscSNhs.hasYsc..pplhlphsKsF	.......................................................................................................Wphphuhshh.ppNlN.pustttph......................h.t...p..st..pu.pulsYphshp+p....hsl..t..sp....ahhththsstGp.hYhss+c........as-....h..s.h.phth..G.h.tapss.....p...pp...h.ulhPa.hp..pph..h......................usctastsh.................Gh..phph.shh..ls..p.Wphsssh.......p.htcp.cY...pcp...............pphsupt..h.h.u.s..o.l.h..a.h.h..s.s..p..t.h....hh.s..G.hs..a....+cps.....p-.......p.s.p..uh.pp..tu.l+h.G...hsp...past......G.lss.ph..p..h..u....a..scRp..Ycs...shh..................s.tR+Dcchphsh....u......l.h..+.c...p...l....p.a.h.GlsPpLsap.ap+s..pSNhs.hYpacp..pphhlphp+pF.....................................................................	0	27	48	65
+2218	PF04481	DUF561		Protein of unknown function (DUF561)	Kerrison ND	anon	DOMO:DM04313;	Family	Protein of unknown function found in a cyanobacterium, and the chloroplasts of algae.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.43	0.70	-5.42	5	102	2012-10-03 05:58:16	2003-04-07 12:59:11	7	3	94	0	40	445	219	236.40	57	91.19	CHANGED	MsN...K..lcsslcp+KAIKVISGLNNFNsspVlpIA+AuptusATYlDIAADPcLVcpVK.ulssIPICVSAl-schLhcuVtAGADLlEIGNFDSFYsQGphlsss-IluLVKpTRpLLP+TsLoVTIPHILsLcEQlpLApcLEuLGlDlIQTEGphouIS.....+scplschIcpSss....TLASTYsIS+sVsLPVICASGLSslTlPlAFuhGASGIGIGSuVo+Ls-ptcMVshlsElpsulSuspsh	.....................................................Lppuhpp+puLKVISGLpNFDtssVstls+AAptGGATaVDIAsDspLVc.hsp.plo.sLPlCVSuV-PctFssAVpAGAshlEIGNaDoFYspGRhFputEVLpLT+pTRpLL.PplsLSVTV....PHhLsLDcQlpL..A.pLVptGAD...II...QT.E....GGT.S.SpP.......hpsGs..LGLIEKAuP.......TLAAAauIS.....R.....A.....V.....s........lP.....VlCASGL.S.s.V.T.s.PM.A.I.u.A.G..AuG..VGVG..S..A..l....N......+....LNDplAMlAsVRuLsEALt....sh............................	0	6	26	37
+2219	PF04763	DUF562		Protein of unknown function (DUF562)	Waterfield DI, Finn RD	anon	Pfam-B_6057 (release 7.5)	Family	Family of uncharacterised proteins.	25.00	25.00	36.60	58.60	19.20	17.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.89	0.71	-4.96	6	19	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	2	0	13	19	0	138.60	41	24.59	CHANGED	phpcFL.hVltDEpEKcVlVVsscup.thcuLssculshLhcELpppGYSYLNIhSscscu.spVpERplLssc.pGRSFTVIls-LPlGssDIRsLQLASERIlVScph-AADAhASGC......KlLpa-c.pssWs....pcatsatcpV-cpt	...hpcFhhhlhhscpE+sVVVVsscu..sh.sLsspuhspLlcELppcGYSYLNIhuhcssu.hpVppRplLsss.pG+uFTllhs-.s.upsDhRsLQLASEthhsu+EhpAsDsYASGC......cllth-c.ppsWs....pcHttatccVccp..	0	0	0	13
+2220	PF04577	DUF563		Protein of unknown function (DUF563)	Waterfield DI, Finn RD	anon	Pfam-B_4026 (release 7.5)	Family	Family of uncharacterised proteins.	22.10	22.10	22.10	22.60	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.58	0.70	-4.42	219	1565	2009-09-11 01:27:59	2003-04-07 12:59:11	9	58	566	0	846	1505	506	202.60	16	44.06	CHANGED	tha....t.Hahh-h.lspl.hhhppthhpps..............hh...hst..thh...sahp......chl.ph.......hul..ttppl.ht....p...p.hhhp.......................plhhssssh.........ththhshhh...........thtphltpphthpt............................................ts.........+hhalsR........tst......pRplhN..pp..cl...h....phhp...............phu.......ap...hlp....sp.phs....hp-Qlp.las.suchlluspGuultNh.....lFh..ps..t....spllpl..s.....pthsht....ahtlsthhshphhhlhsps	.......................................................................................................................................................................................................................................................................................................h.....................t..........h.............t............t.hhh.........................................thhh..............................................................................thtp.hlhpthshsp................................................................tts.........plhhlsR...........sp..........pRtl...hN...ps......-l....h.............phhp..............................................phs................hp..........llp......hc...phs....................h.tptlp...lhs....su.chllusHGAuLssh....lFh...ss...........s.....usllcl...........hthp.t................ahthuph...shph......th.......................................	0	442	611	734
+2222	PF04483	DUF565		Protein of unknown function (DUF565)	Kerrison ND	anon	DOMO:DM04315;	Family	Predicted transmembrane protein found in plants, chloroplasts and cyanobacteria.  This family is also known as YCF20.	21.10	21.10	21.20	22.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.81	0.72	-3.81	19	173	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	110	0	85	173	161	59.50	33	43.19	CHANGED	Qpu-WDllsAulllshsEhlutlhYpph.........ppp.th......hlphlNhhKlGlhYGLFlDAFKLGS	................u.hDllsAsllVhhhEhlstl...hYptsh................................htp.th......hlphlNhaKhGlhYGLFl-AFKLGS........	0	16	55	75
+2223	PF04525	Tub_2	DUF567;	Tubby C 2	Waterfield DI, Finn RD, Eberhardt R	anon	Pfam-B_4998 (release 7.5)	Family	The structure of this family has been solved. It comprises a 12-stranded beta barrel with a central C-terminal alpha helix. This helix is thought to be a transmembrane helix. It is structurally similar to the C-terminal domain of the Tubby protein [1]. In plants it plays a role in defense against pathogens [2].	24.50	24.50	24.50	24.70	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.36	0.71	-4.90	16	987	2012-10-02 20:44:47	2003-04-07 12:59:11	7	6	608	2	363	768	7	155.80	24	85.77	CHANGED	thhlss.ahsstthsLslhh+shhhsssuaslhDspGpllF+V-s.....hphscchhLhDssGpsLlol+c.K.....hhoLtspWplapusssp.......p.lFsl++s.....l......psahh..ssh...tppspsapIcGshhpcuhplhc..psspllApl+...s..pshhhGcDsasl.hVpsphDhuhlhuLlll	...........................................ht...................hhl.pp..h.hh.t.........s.c.p.Fsl....p......D.s.p.G......p.....lsapV-G..........ph....h..p.......hs.....c..phtl.......hD.s.s.G.c.......l...h.pI.p+..c...................hh.o.h...h.s.capl.h....ts.sp.p.....................h.as..l+Kp................................sFh....t....................s...h...................t..p....sh.shcl..cG.s.h..h...c....h..s.....aplh................p......s......p...s.....p.....llA.clp.....................p.......p...h.......h.th.......s.....s....s....asl...sV.h....s....h........ss...Lllulslh.................................................................	0	59	216	293
+2224	PF04601	DUF569		Protein of unknown function (DUF569)	Waterfield DI, Finn RD	anon	Pfam-B_4902 (release 7.5)	Family	Family of hypothetical proteins. Some family members contain a two copies of the region.	21.20	21.20	21.20	21.90	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.78	0.71	-4.76	7	184	2012-10-02 19:42:32	2003-04-07 12:59:11	8	6	19	0	119	175	8	140.00	37	47.43	CHANGED	MElFpcAcuVRLRS..pHDKYLhAD-DEEoVpQsRsGou+pA+WTVE.V..sp.clIRLKSCaGpYLTASNc.FLLGhTG+KVlQotshR..hDpss.-WEPlREGupVKL+oR.G.paLRuNGGlPPWRNSVTHDh.PHhSsTpc.llW	...............MEhFpcuphVRLRS...tp.sp..YLhAD-....Dt.....psV...sp...s...+......s.u..u.....u..h..s....Ah.WsVE..h..l..................s......s....s......s............h.........lh...L...+.S.s.Y.G+YLsA....o...st.......h....h...h..G.h.s..Gp......+....VlQs............t...p..................h-.s.sh......W....c..s.l..........+......c....G...s.......p......l...pL...+........s.t.....G.......pa..LR......ANG.......s.h....sW.csu.VTh.D...st.t..........................................................	0	12	63	92
+2225	PF01881	Cas_Cas6	DUF57;	CRISPR associated protein Cas6	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats [1]. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation [2]. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers [3].	23.60	23.60	23.70	23.70	23.40	23.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.12	0.71	-3.99	46	464	2012-10-01 21:23:39	2003-04-07 12:59:11	11	3	348	9	200	474	12	148.10	20	61.04	CHANGED	hsuLh....ppsphpls...s....tpaplccl..chhcp.ch.ppphpFpTL..SPlllpshh.........sphpphaltPp-pc.....FhchlppNLhcKYpth.....hucp.p...pchphch.....h+t.....+hlphK.......pth..l+uhhhh.Fclpus..cllchuY-sGhGpKNuh.GFGhlcll	...........................................................................................h.........t...h.ht....t.....ph.hl.ppl....phhp...p.........h..ppph..hhpsl.....S..Plllppt..............ptpshahpsp-..pc..........FtchlppNlhcKa..pth..............hspp.hp....pphphps........h...th+....h.phhph+....................shh.....lpuhh.sh.acl.....pus....c...ll.....phsa...ps...GlGp+sup.GFGhlch..................................	0	73	128	169
+2226	PF04489	DUF570		Protein of unknown function (DUF570)    	Kerrison ND	anon	DOMO:DM04330;	Family	Protein of unknown function, found in herpesvirus and cytomegalovirus.	25.00	25.00	32.00	31.60	16.80	16.20	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.45	0.70	-6.07	4	48	2012-10-03 01:18:03	2003-04-07 12:59:11	8	1	25	0	0	44	0	393.40	47	68.12	CHANGED	ss.u..hpsshp.pssaG+uI..Aohpp+.ppsh..R+HLshYpuhLhsIlcQYpp.hlPsptphpYcpGtIclushlls.spQlsutp......lYsWoolshPKhhuhtELaFLlsSscppslshpPhITKGGhhSu.hoY...Phs.SsshslshlpsslhMlPFlPa+hPhhhs.hhs...........sh.hLppttst.taGplp.lKp+shhhLullcsLTWppphshs.psphhphhtA.FhGohss..stlP.-shAhRhhsNspaphtsaEFoINl-Nlsls+spcKllGTLATssCcphsspLosENhPphLllpFELloshpcs.cLhFSsNPpLaFoGDlLNss..L.psPNhaELpVaAPYDlHFhsuppHhVpLslRYhphsDRp.hLVSsh.sEshFcTthslWtsssPL+lTLhSao.NLlLPQGT.lAsLhhl	..............ohhEuhR-s..spssYG+sl....p.cs+.l+..Rot...pHLosYcshLhtlscQYNp.sssspt+ApYhpGsIahuhsVIhsstpssshp.......YsWosllsP+s.shsELaFLLCSsptsusVhQPhITKGGhpouhhsa...s...tps....pss....phshl+spLshlPFVPassPcauV.FhT..tcsuh.....................h.hlp.....tAs....FGpho.VpRpGushlshhcpLoWhs+plhs.sppchTpYlA.FcGTh-s..uhhsu.scsWhs.+NVpYEhhsh.FolNV-SlsVsspp.RpLlGTluouhCcps.os.ploscNMPp..shpF.Ll.sotpRt.slhFSpNPoLFFoGDuLN.s..L.ppPssasLTVHAPYDIpFt.psppsVplDlRYsphsDR.CFLVuslPpE..stFaTGLoVWRsspPL+lTLhShT+ollIPQGTPIAsLY.l..	0	0	0	0
+2228	PF04672	Methyltransf_19	DUF574;	S-adenosyl methyltransferase	Waterfield DI, Finn RD	anon	Pfam-B_4601 (release 7.5)	Family	This family contains a SAM (S-adenosyl methyltransferase) domain, with a central beta sheet with 3 alpha-helices on both sides. Crystal packing analysis of the structure PDB:3giw from Swiss:Q82L35 suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the residues His57, His170, Phe171, Tyr216 and Met22 . The UNL is likely to be a phenylalanine or phenylalanine-like molecule. (details derived from TOPSAN).	20.00	20.00	20.00	20.10	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.57	0.70	-5.13	12	720	2012-10-10 17:06:42	2003-04-07 12:59:11	7	2	101	4	349	788	2	255.20	39	95.90	CHANGED	stttsspIDTo+PHsARlYDahLGGKDNYPVDcpAu-shhtshPthhtsAptNRsFhpRAVphLAt-.GIRQFLDIGTGlPTtsNlHQlAQplAP-oRVVYVDNDPlVLsHucALLsusP-GhTsalcADl+cPcpILp..cstcsLDFsRPVALhLlAlhHal...sDs-DshulVcpLh-sLPsGShLsLScsos-hsPthh...ctstshaspu..utshphRohp-lttFFc..GL-LlcPGlVssscWRP-ssts...........................sstthshauGVARKs	............................................s.....tlDsshPpsARlYDaaLG.GKDNassDRpsucphht....hhPph..h..t..hAptNRsFLpRAVRaLAs.c.GlRQFLDlGoG.lP.T.t.................s....N..........lHE.VA.Qpl......s...P..-...uRVVYVD.NDPlVLuHu+ALL.su.s...s.p......Tsh...lpADlR-PcpILst....pspchLDh.sc.PVALh.llulLHa.l.......sD....p.-......c.s.t.slV.pplh-sLssGSaLs.lo..H......s....o.....s......-....h.s.....s....p.t..h..........pt...s....t...p.h....h...p..ps........ss..s.h.....t...hR..opp-ltpaFc...GL-Ll......-......P.G......lV.s......sp....W...RP-s.sss.............................p.s.tt.h.hauG.VuRK...............................................	1	125	277	340
+2229	PF04746	DUF575		Protein of unknown function (DUF575)	Waterfield DI, Finn RD	anon	Pfam-B_6048 (release 7.5)	Family	Family of uncharacterised proteins.  Contains several chlamydial members. 	25.00	25.00	80.70	79.60	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.26	0.72	-3.98	6	20	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	2	0	15	20	0	97.00	55	18.45	CHANGED	AFDFoRPlCSRITNFALGVIKAIPIlGHlVhGl-WLlSph.tphls+PsFsSDVssIlKlEKstG+DHluRVEphL+p.RlslssED.sKVHG+hPpsPFs	AFDFo+PhCSRITpFALGVIKuIPllGHllhGl-WLlS+hhcphVo+PsFsSDVssIlKlEKlsGRDHIuRlEshLKp.RlsIssED.DKVHG+hPpsPF.u	0	0	0	15
+2230	PF04507	DUF576		Protein of unknown function, DUF576	Mifsud W	anon	Pfam-B_2120 (release 7.5)	Family	This family contains several uncharacterised staphylococcal proteins.	20.00	20.00	20.40	20.30	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.62	0.70	-5.46	29	2553	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	198	3	28	1021	1	231.00	55	98.31	CHANGED	MpahK+lsLhISlllLhlhI.uGCGh.s..........K--SKEspIKKSFsKTLsMYPIKNLEDLYDKEGYRDsEFcKsDKGTWlIpS-MshpsKGcshco+GMVLhlNRNTRTuKGaYhlcclp--pcthspsp-KKYPVKMcNNKIIPhcpIcDcKLK+EIENFKFFsQYGsFK-LcsYKsG-ISYNPNVPsYSAcYpLsNsDhNVKQLRKRYsIPTpKAPKLLLKGsGDLKGSSVGaKclEFTFlcsKcENIaFoDSlpFpPSc	............Mhh.p+lhLhIsh.ll.Lhlhl..sGCsh.p..............ptsuKEtQIKK.SFsKTL.sMYPIKNLEDLYD..KEG.Y..RDs..EFcKsDKGTWhI.Schshps.Kscphcs+GMVLalNR.NTRTsKGaYhVpphhc-pct.h..........p.s.pcKcYPVKMhsNKII.hcplcD-KLKKcIENFKF.FsQY.usFK-lpsYcsGDlSaNspVPSYsAcYpLsNcDhNVKQLR+RYsIPTpKAPcLhLKGsGsLKGS..SVGaKclEFsFscpKc-slhasDSlpapPo....................................................	0	11	11	27
+2231	PF04510	DUF577		Family of unknown function (DUF577)	Finn RD	anon	Pfam-B_3938 (release 7.5)	Family	Family of Arabidopsis thaliana proteins.  Many of these members contain a repeated region.	20.90	20.90	20.90	20.90	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.18	0.71	-4.57	17	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	9	0	49	54	0	158.90	33	38.91	CHANGED	l+EIpPLLIoCLp.pphp.-SphKlLtclVSpVAaplh.hpcssW.ELpDhIhShu.ppE.hKAhalF.sLs.sl.hc-Flh+hhcs.ll.chpphLhsPpc..scspsWsLAhpsshphuIpLl-ssh+.schl+clhph....hlcSV+cLVp+GhE.thlhRuhc-lEphVp+phphYphoc	....................hhplpslLIsCLp.pthp.po.hKlLtplVspVsh.pl..h.hpctsW.-Lt....-hIho.u..ps-...+AhhlF.sLs..l...c-Flh.hhcp.Lh.ch.phL.sPpp...cspsWsLAhpuuhphsIpll-sstp.schlcclhpp....hlcSl+-LVp+thE.thlh+uhcchEphlpcphphYphs.t.................	0	25	29	30
+2233	PF04669	Polysacc_synt_4	DUF579;	Polysaccharide biosynthesis	Waterfield DI, Finn RD, Eberhardt R	anon	Pfam-B_4574 (release 7.5)	Family	This family of proteins plays a role in xylan biosynthesis in plant cell walls. Its precise role in xylan biosynthesis is unknown [1,2]. Its function in other organisms is unknown.	20.40	20.40	20.70	21.70	18.50	20.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.34	0.71	-4.93	29	437	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	248	1	286	418	7	142.80	30	66.25	CHANGED	hEhphuh+slc+tps.hNlLshs.ssp.....pLhhstlscp.............hhpphccpaPslc.......scl.h-tccLhust.....................................tcpcW.hhhhss.cshht-........ashGslhRscsstsho..sslFVpcl..........pFhshEhtpsptGhsphhah	.............Ehphus+slp+tps..hslLshs....ssp.....pLhho.phs..cp............................hhpph.......c.....cpFP...p..h..c...........sph..hct-cLhutt..................................................hctcW.h.hhpt.c...shhp-...........ashGsLhRscsstths..ss.lFlhch..........pFhshEht.psptGh..hh.........................	0	68	151	223
+2234	PF01882	DUF58		Protein of unknown function DUF58	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family of prokaryotic proteins have no known function. Swiss:P71138 a protein of unknown function in the family has been misannotated as alpha-dextrin 6-glucanohydrolase.	21.60	21.60	21.60	21.60	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.81	0.72	-3.84	161	3991	2012-10-10 16:07:06	2003-04-07 12:59:11	13	9	2067	0	1413	3655	957	85.30	25	23.95	CHANGED	st-ats.lRcY.psGDsh+pIcW+soAR........t.sp...Lhl+ca.ptpp.p.....tplhlhlDtsts.......................................tphEttlphsss.....lshthhp.....pspthul	................-atp.lRpYps.G.DclRpI-W+so.AR...............p..sc........hhl+..pa.cp-p.p.......ts.lhlhlDhsssh..h.stt.......................................................tch-hul.phsus......lshh.shp.....pssphs.............................................................................................................................................	0	508	1002	1244
+2235	PF04515	Choline_transpo	DUF580; 	Plasma-membrane choline transporter	Mifsud W, Pollington J	anon	Pfam-B_2258 (release 7.5)	Family	This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals [1].	22.10	22.10	22.30	22.10	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.83	0.70	-5.70	73	1097	2009-12-17 12:57:17	2003-04-07 12:59:11	7	15	292	0	722	1057	28	295.60	23	51.13	CHANGED	hhhllhshh.llhllhh..........................hhhppRI.hussllcpuscshp.ph.plhhhsllshllhhsahshashshlslhsptps....shps.s.....................................................................................tlhhhhhahlFuhhWhsphltslhphslA.GshusWYastpp....shPptsshsuhpRuhp.....YphGSlshGSLllullphlRhllchlppphpttt.....s.hhthlhpshpChhtsl-phlcahN+.AYlhlAlaGcuahpuAKcsapLlpp.sslcslhssslsshhLhluplhluhhsulluahhhph..........psshsashsshhhshlhuhhls.plhholhpsul-TlFlCaspD.ph.ppss	..................................................................................................................................h..hlhhhlh.thlhhh.hh..........................hh....hppR..l...h..sh..tllp.u.s.cslt...ph.thh..h..........h..sh.hsh.hhhhhh...hs..h.Wh.h..sh.l.h..l.hss.s..ps......p..t...............................................................................................tt...............hhhhhh.hahlhs.hhWh.sphlhuhtphslA.Gshusa....Yashpp.............shst..............h........s..l..h.s.u......ht...+sl.p...............aphGSl...shGS.Lll.sllp....h.hRh...........l.l..........p.hh.pp....phpttt.....................s.h.phhh.psht..C...hhhhl-..............p.hlcahNc..AY.........hhhAlhGpsFspuA+................psa.llh.........p..shh.cs..h......h.....hsp.........l......sshll....hh..u..pl.hls..h.hsu...hhuh.....h.hhp..................................t.th.phhh...h.sh.h..hs..h.h................h....uahls.phhhs..l...ht.sl-olalCas.D...h...........................................................................	0	287	424	583
+2236	PF04570	DUF581		Protein of unknown function (DUF581)	Waterfield DI, Finn RD	anon	Pfam-B_4765 (release 7.5)	Family	Family of uncharacterised proteins.	23.40	23.40	24.00	23.40	23.20	23.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.43	0.72	-4.68	42	427	2012-10-03 05:12:49	2003-04-07 12:59:11	9	3	27	0	245	398	0	55.50	39	30.63	CHANGED	stsstsstsstss.ssFLpsChLC++pLs..scDIaMYRG-pAFCSpECRppQh.hDEtp-	..............hs..........tsspFLpsChLCp+.pLs..scD.....IaM.YR..........G-pu...FCSpECRppQh.h.DEt.............	0	20	132	192
+2237	PF04518	Effector_1	DUF582;	Effector from type III secretion system	Mifsud W, Eberhardt R	anon	Pfam-B_2447 (release 7.5)	Family	This is a family of effector proteins which are secreted by the type III secretion system [1,2]. The precise function of this family is unknown.	21.00	21.00	21.50	22.40	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.21	0.70	-5.47	20	164	2009-09-14 12:27:57	2003-04-07 12:59:11	7	1	35	0	22	81	0	380.30	32	51.67	CHANGED	plpsphsshstspspFss..sshsshpshplasphssspstls.shhtssspthlsshpps..s.uppspphhppapstAssplpplpppIsphppphtchsstKAohsss.......hphupsshlpopPLtSAauSllLD+YlPpQpphLpsLtpclsaSNhAushhNsllchlssFsouslYYsLuSYlsQ.....ppGtstFssuhtpApstLscE+ppsppDlppspcApshlspllsplpsDs...clTsuQ+pclh-slssYptplsslhssLssLpshLssLpl.........hsssspscssFclps.......-sWhtpLpsLEuhllsG...hssusssGGhhslhsplpuDQQsYsshuQNQQLsLQhchouhQQEWTlVusSLpLLNQIaspLsRp	......................................s.psphpphs.tpppaps..ssts.hpthplh....sphpsspshls.hhhtshspthlsshppsh.ptuppspphhscapstupschpclppplpphppphpplsstpsshssp.......ht.ApsshlcshPLtSAauplLLD+YlPpQpphLpsLtpclpaSNhAushhNsllchlspFssuslYYNLuSYlsQ.........ptupshFssshppspspLscE+pphctDlpp.......sppApphlppllppVpsss...plTspQ+sclp-tlssYtppLsslhspLssLpshLssLsh..........sssspscssFclhu......tcpWhhpLpsLEstllsG...hssusssGGhhshhs.lpoDQQsYsshuQspQLtLQhphouhQQEWTlVusSLplLNQIatpLspp.....	0	5	5	18
+2238	PF04519	Bactofilin	DUF583;	Polymer-forming cytoskeletal	Mifsud W	anon	Pfam-B_2455 (release 7.5)	Family	This is a family of bactofilins, a functionally diverse class of cytoskeletal, polymer-forming, proteins that is widely conserved among bacteria. In the example species C. crescentus, two bactofilins assemble into a membrane-associated laminar structure that shows cell-cycle-dependent polar localisation and acts as a platform for the recruitment of a cell wall biosynthetic enzyme involved in polar morphogenesis. Bactofilins display distinct subcellular distributions and dynamics in different bacterial species, suggesting that they are versatile structural elements that have adopted a range of different cellular functions.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-10.41	0.72	-4.00	160	2175	2010-01-08 16:00:08	2003-04-07 12:59:11	8	16	1383	0	671	1765	1447	96.10	23	54.70	CHANGED	tsolIupssplpGslp.hsu.slpl-Gp..lpGslps.ps....plhlupsGplcGp.lpup.plhlsGp..lpGslpupchl.pltssuplpGclpssp.lplcpGuhhpG.phph	............................h..shlstshp.hpG.p...lp.hps....tlpl..c..Gp...l..p..Gs.lps..ps......plhlupsup..l.c...Gs..l.p..s...p....p.l.hl...s...G.p........l..p..G.....s.....lp.u...p.p..l.pltssuplp.G..s..l...p..s...pp.....lplptGuhhpGph..h.......................................	0	268	476	575
+2239	PF04520	Senescence_reg	DUF584;	Senescence regulator	Mifsud W	anon	Pfam-B_2571 (release 7.5)	Family	This protein regulates the expression of proteins associated with leaf senescence in plants [1,2].	21.50	21.50	21.50	23.40	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.18	0.71	-3.72	22	277	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	33	0	170	265	0	149.00	31	84.22	CHANGED	sth....ELsEsDla.ss...................................................pssusssshpsu......sss+th.th..............ssssssthtpSAPVsVPshuth..........pptcs.pptcs--p--t-ss.hlPPHEhlAR......Rcsuuh..SVhEGsGRTLKGRDLR+VRNAlhc+TGFhD	........................................................................................................t...-h.Et-lh.........................................................................................t.t....t....t........t.sthh..t..............................tstsssthhtpSAPVsl..Ps.hsphht...........................tttptt.t..tt.c.s.s.......c....pc..c.....s.......s.........ssp...hlPPHEhlA.R...................pptsuh........SVhE.....Gs...G.RTLK.GRDLp+VRNAVhcp.TGFl-.......................	0	18	95	134
+2240	PF04522	DUF585		Protein of unknown function (DUF585)	Kerrison ND	anon	DOMO:DM04368;	Family	This region represents the N terminus of bromovirus 2a protein, and is always found N terminal to a predicted RNA-dependent RNA polymerase region (Pfam:PF00978).	25.00	25.00	233.10	232.40	18.60	17.60	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.67	0.70	-4.98	5	16	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	6	0	0	16	0	246.00	51	30.16	CHANGED	M.SKFlssD.EYpVPSFQWLIDpSLEc..s.-sElAshVsc..s.....-PcsElTADGSLASFlLAVKPLVIG.Gpa-PPFDQARWGsCCcsVssls-uFTc++LIPhAEMARMLYLDI-GSFVDESEsDDWhPEDTSDGYsEYhuuDEsch.t...us-LppsLucEssshEh-EscEsoD.....SsPS...EhTLGDRYlsTsEEFtol-.SDYslTLNLhNPVEpRVullEDTascs-sD-.hspuPpYpERVSLcuLEAAGH	...MSKhhs--.sYpVPSFQWllDQoLEs..s.cs-sAthlsp..s.....-susElssDGoLASahhAVKPL.IG.Glh-PPFDQARWGpsCcsVhslspthsshtLIPhAEhARMLYLDI-GSFVDESEsDDWhP.DTSDGas-shusstsch.t...pochpp..hLup-usphE.cpsccToD.............sPs.....EhTLGDRYhshcEEFtol-.oDYDIoLsLhsPlEp.RVuhl.DTasHs-ssD.hsThPhYh-RlSLppLEAAGH	0	0	0	0
+2242	PF04532	DUF587		Protein of unknown function (DUF587)	Kerrison ND	anon	DOMO:DM04375;	Family	This family consists of the N termini of some human herpesvirus U58 proteins, and some cytomegalovirus UL87 proteins. This region is always found N terminal to the Pfam family UL87 (Pfam:PF03043), which has no known function.	19.30	19.30	22.20	199.50	17.20	16.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.32	0.70	-5.40	8	45	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	27	0	0	40	0	215.80	55	24.92	CHANGED	hp.psup-A..LIVcSsss..p+shsVPVaVNSaNLTpElSssEDuRLspssP..VDsE+lculFcsLapAuPsplcs-pDRsKllLsRLLLGPVAVPCYC-.EW-ss...............-YLscsuhtCpGPlLYVHRtRC+Cs..sstsshpFoVMcsahuTHVFRGLLSLpEWNs+LPslFCsC.....ssspsDRYshslLP+chSlaL-hYPYhLspLsRaLoVsEIDDhsNslI	......ush...phss-ALIVhusoA...hRVhsVPVaVsohNLTpELSssEDARhspstP..VssE+VcuVFtuLYpAsPsal.............cTEp-RsKlVLsRLLLGPVAVPCaCD.EW-sc...............-aLscssphCpGPLLYVHR.RCpCG....ssGpuLsaoVLcsHhATHVFRGLLSLoEWNpcLPslFCsC....ssuspp-RYsMAsLP+-hSlaL-.YPYhhVcluRhLoVsElDDhVsuh.o	0	0	0	0
+2244	PF04569	DUF591		Protein of unknown function	Mifsud W	anon	Pfam-B_2799 (release 7.5)	Family	This family represents a conserved region in a number of uncharacterised plant proteins.	21.00	21.00	24.30	24.30	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.21	0.72	-3.94	49	201	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	3	0	185	199	0	81.40	47	29.53	CHANGED	uGpR.........c...tpssupsspRs..ssspsGuppssp.....uctc+...p.GhhttsRGs-PoARIRppthDG..G..shRRRpPAApcG....Gssctso.R..................s+F.ustASst	................................................G.R........c..hpcss.utsGRRs..sssssGup+usp........Gcuc+....TGhhttsRGsEPsARIRpRtlDG....GthRRRQPAAtct....GNGDEsT..R..................GRFsusRASst...................	0	0	0	0
+2245	PF04574	DUF592		Protein of unknown function (DUF592)	Kerrison ND	anon	DOMO:DM04429;	Family	This region is found in some SIR2 family proteins (Pfam:PF02146).	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.87	0.71	-4.66	14	90	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	54	2	54	87	0	117.70	34	26.38	CHANGED	phhP..ptP.ppsl.ls+s..ssKalhstho+--olNARhaLKhaG.tcFL-sYLPp-lNSLalYaLIKLLGFplKDppLhssl.p.hp..hp.s.t..ht.....................t.pDPL-KKphl+LIKDLQ+AhsKVLuTRlRLsNFhTl-+Fls+L+sAKKILVLT	.............................h......................hhh.ths+cpshpsRhaLK..shhpFL-haLP.phso..lhhhIthLGFt.+-.thh.................................................pDsLtccphhcLIK.Lp+AlsKVLspRlRLssF.TlDchlptL+sA++ILVLT...............................	0	8	25	46
+2246	PF04578	DUF594		Protein of unknown function, DUF594	Mifsud W	anon	Pfam-B_2859 (release 7.5)	Family	\N	21.00	21.00	21.70	21.30	20.10	19.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.99	0.72	-4.52	66	634	2009-01-15 18:05:59	2003-04-07 12:59:11	8	22	16	\N	390	558	0	57.80	34	8.75	CHANGED	pLh.......htsppphWclluclWsEhLlYsA....s...pssupsHucpLupGG..EhlThlWhLhsHsGl	.......................hh.........ptpptWcllsclWsEhLhYsA..s......ps.ss.ptHAcpL.upGG..EhlThlWhLhtHhGl........	0	6	138	264
+2248	PF04591	DUF596		Protein of unknown function, DUF596	Mifsud W	anon	Pfam-B_5061 (release 7.5)	Family	This family contains several uncharacterised proteins.	25.00	25.00	26.10	37.00	22.60	24.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.53	0.72	-4.07	19	144	2009-09-11 22:03:20	2003-04-07 12:59:11	7	1	49	2	24	99	0	70.10	52	56.83	CHANGED	LD-G+LKLu.+KG-aI.pGoT-ELV-MFRpuFPs..SDEEh-.........tGlWFhs-p.CPhsAVWlaKGtt.....ENGEDYY-Ws	.LDEG+LKLu..++Gc..Fl.sGTo-EhVEMFRpuF.Ps...SDEEh-.............tGhWFhs-...pCPuGAVWVhKGt.....tENGEDYY-Ws....	0	1	12	21
+2249	PF04640	PLATZ	DUF597; 	PLATZ transcription factor	Mifsud W, Riaño-Pachón D, Mistry J	anon	Pfam-B_5458 (release 7.5)	Family	Plant AT-rich sequence and zinc-binding proteins (PLATZ) are zinc dependant DNA binding proteins.  They bind to AT rich sequences and functions in transcriptional repression [1].	25.00	25.00	25.10	25.10	21.20	24.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.53	0.72	-3.77	12	304	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	36	0	210	282	0	71.90	52	29.08	CHANGED	RR.sYHDVlRVs-lpKllDhSsVQTYlINSAKVlFLNcRPQsRssKG..........ssNsCpsCsRuLh-s.F+FCSLuCKl	................RRtSYHDVlRVs-lpK.l.lDlSsVQTYlINSA+VVFLN..cR..P.....Qs...R.s..sKG................................ss.stCpsCpRuL..h...D.s...a+FCSLuCKl.............................	0	34	136	177
+2251	PF04654	DUF599		Protein of unknown function, DUF599	Mifsud W	anon	Pfam-B_5550 (release 7.5)	Family	This family includes several uncharacterised proteins.	21.10	21.10	21.50	26.70	18.20	20.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.25	0.70	-5.19	46	411	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	270	0	210	414	55	205.50	27	85.43	CHANGED	hlulshhlhsWhGYshahpppstpps..olsshhsphRctWhpphl...sR-s+.lhDspllusLppusuFFASoslllluGlhslluss.......-phhslhucls..hsstsschhhplKllsLlhlFlhAFFpFsWShR.asasulLlGusP.....tp.........ststtshAppsupl.shAuppaNhGLRuaYFuluhlsWhhuPlshhhsolhlVhlLapR-FpSpshpsl	......................................lhlshhlhshhuYp..hah.hhpstpps...olhsh.sthRctWhpphh....pccpp..lhssphltsh.tusoFhASos.lllhuGlh.slluss................pph..tphhssls....h..ss.p...sphh.h...plKhhsLhhhFlhAFhpFshuhRhasasulLluuss......p..................t.ttt.hhsptsuchhppAuptashGlRuaYauhshlhWh.huPhhhhhsohhhlhlL.ap.h-hhSpsh...h................	1	47	122	162
+2252	PF00892	EamA	DUF6;	EamA-like transporter family	Bateman A	anon	Pfam-B_177 (release 3.0)	Family	This family includes many hypothetical membrane proteins of unknown function.\	      Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.39	0.71	-4.09	98	66028	2012-10-02 19:55:49	2003-04-07 12:59:11	15	83	4851	0	17444	56174	36728	125.00	15	75.68	CHANGED	hhauhshlhs+hhhpp.....hsshthsshphlhus..hlhhhhhhhttt.............hhshpthhhllhlulhssslshhhhhhu...lphssuspuuhlht.hhPlhshlhu.hlhLtEplshhphlGhllslhGlhllhh	.................................................................................huh.h.h.h..h..h..p..h..h..h.tt...........h.s...s....h.....h....h......s...h....h....p....h...h..h..u......s...........h....h..hh..h...h.h.h.h.tt................................h.h.h.s.h.p...t...h......h....h.....h.........h.....h.....h.........u...l...h...s....h....s.....l..s...h.....h.......h...h....h..hu..........l.p...t......h....s....s..........s...t..s..u..h....l..hh....h...t...P....l....h.....s........s........l........h..........u....h..........l..........h........h........t.........E............p........h.........s..........h.......h......p........h......l......u......h......h.l..s.l.hGlhlh..h.....................................	1	4905	10337	14119
+2253	PF04634	DUF600		Protein of unknown function, DUF600	Mifsud W	anon	Pfam-B_5411 (release 7.5)	Family	This conserved region is found in several uncharacterised proteins from Gram positive bacteria.	21.70	21.70	21.70	21.70	21.20	21.60	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.76	0.71	-4.18	15	1266	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	296	4	43	633	0	133.70	58	88.36	CHANGED	LsplYpEIAppIsshIPsEWEKVYhhApls-cuuEVaFaYspPs.S-EhhYspsIsccaNlsccpFhcphh-LachFc-LRctFK-sstEPWTShphshs+sGKhslcFDYpDhh.po-asphtRphhapYK+hGllPEs..E.-hEhlcc	................................LSphYNEIANcISuMIPV.EW..E..KVYThAY..ls..D..p..G.GE..V..hFNYTcPu...S-EL.YYosI.......s+....cYNlScplF....Dhh.......h-LYchFccLRslFK..EEs....hE..PWTSCEFDF.T.c-.G.K.LpVSFDYIDWl.soEFs.hG.RpNYYhYKKFGllPEh..EYEhpclKc.............................	1	15	23	33
+2254	PF04645	DUF603		Protein of unknown function, DUF603	Mifsud W	anon	Pfam-B_5498 (release 7.5)	Family	This family includes several uncharacterised proteins from Borrelia species.	22.10	22.10	22.20	33.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.99	0.71	-4.34	3	189	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	29	0	14	166	1	164.70	61	95.50	CHANGED	MKRAKRSFDDYVAYF+EGSLSDsEIAK+LGVSRVNVWRMRQKWESGEsS...VNEDSRVTISEDTFEHLLuQTF+SEVpARKVKSELDLERSNLELGFINAFKQYSSlELsSMhoKIEsLRuKIDSLNKpsNKKNtpsVNEE...INSLKlELDELIKECpIREMELYYECMKKLAsAHEVDSKSNY	........MK+sKRSFDDYlsYFpEGsLsDhEIAp+LGVS+VNVWRMRQKWESGEss............VNpDSRVTISEDTFEHLLuQTF+SEVpA+KV+SELDLERuNLEL..GFIpAFKQYSSlELsSM+o.KIEsLRsEIDuLNKuusKKNKpsVNt-...INSLKSELsEhIKECSIREMELYYECMKKLssApEsESKSNY..............	0	8	8	8
+2255	PF04646	DUF604		Protein of unknown function, DUF604	Mifsud W	anon	Pfam-B_5503 (release 7.5)	Family	This family includes a conserved region found in several uncharacterised plant proteins.	20.80	20.80	20.80	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.72	0.70	-5.16	17	290	2012-10-03 05:28:31	2003-04-07 12:59:11	7	9	78	0	208	320	1	203.90	35	42.72	CHANGED	QNlhFSYuMAaGGGGaAISaPLAstLu+h.DsCIcRYstLYGSDcRlpAChuELGVPLT+EsGFHQhDlhGslhGLLuAHPlAPLVSLHHLDhV-PlFP.sh..sRhsAl++Lhp.sscLDsupllQQSlCYD...........+..pppWTlSVSWGYsVQlhpuh..............lssRElEhPtRTFhsWh+pus.hssasFNTRPl.scs....sC.p+PhlFahssspts....sps...tThopYp+phhtt...spC.pashssP.sclcpIhVhp.+PsPphWp..+uPRRpCC	......................p.hauas.M.AaGGGGhAlShPLAptLs..c..h.DpC.....l...........pR.Y...s.....tl.....a.....G..S...DsRlpuCh.u......E.L.........G.Vs....LT..c....-.............GFHQ........h...............DlhGch...hGlLsuH.PlsPllSLHHh.-...h...h..pP.la....P.....th.....sp.t..u.l...phhh...t...shp.hDs.thhQpsh.CYs..............t..t.th...ohuluhGasl.lh...................h....ph.hs.pTF.sW.t..t.....a.hsT+......p......C.tpPhhaahpps................t.......hhs.Y.h............h....................lp.l.V.t................................................................................................................................................................	0	37	125	168
+2256	PF04657	DUF606		Protein of unknown function, DUF606	Mifsud W	anon	Pfam-B_5554 (release 7.5)	Family	This family includes several uncharacterised bacterial proteins.	21.80	21.80	21.80	22.00	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.66	0.71	-4.09	147	2941	2012-10-02 19:55:49	2003-04-07 12:59:11	8	4	1497	0	499	1852	371	136.10	27	86.54	CHANGED	lhhl.lulluGhhlslQsulNupLupt.lG.tshhAuhluahlGhlsl....hllhlhhp...t................shtt..ht......ss....PhWhal.GGllGshalhsshhhh.PclGsshshshllsGQllsulllDpFGhhGhsppslsht+llGlllllsGlhl	..........................hhlhslhuGhhlslQ.sslNupLupt.....hu....s............sh....hus....hlsahlGhlhh..hhlh...hhhp..s...............phtt..ht.........................sh.......sh.ahhl.GG.lLGshhlhsshhhh..sp..lGsuhshsh...hlsGQllsulllDpFGhhGs....tpshshh..+.llGslhlllGlhh...............................	1	148	281	409
+2257	PF01886	DUF61		Protein of unknown function DUF61	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Protein found in Archaebacteria. These proteins have no known  function.	20.40	20.40	20.80	21.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.59	0.71	-4.31	17	84	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	82	0	58	78	1	126.40	28	91.20	CHANGED	h-+hlphtltplNpclPtcRKoLpELLpE-+PhlhlpsGscHhhc+cELEhLpphlsp-.hthl+lPIllEhpSohtpGshhlpGct.ElKsIp+lLshchs...tpshlhlh+..l.plRRcLPTsTphhFlh	.............-+hlpttlpplNpphPtcR+oLp-LLpE-+Pplhlps.GppHhh++cELEhLpphls...tp.hphl+lPIllchsss.htpGthhlpGct.cs+slsplLGtcht......pshlhl.+..l.plR+tLsTsTphhFh................................................	1	14	29	46
+2258	PF04748	Polysacc_deac_2	DUF610; div_psaccdeacet; 	Divergent polysaccharide deacetylase	Waterfield DI, Finn RD, Yeats C	anon	Pfam-B_5949 (release 7.5)	Family	This family is divergently related to Pfam:PF01522 (personal obs:Yeats C).	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.16	0.70	-5.32	134	1399	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1342	3	291	924	146	203.80	39	64.31	CHANGED	IlIDDlGh....phtsscslhsLPhslThAlhPhsststphuptA...+ppG+ElllHhPMpPhs.......t.p.sstsLhsshsspclppplptshsplPtshGlNNHMGSthTpsppsMphlh......ptLppp.sLhFlDStTsspShAtphApphGlsshpRclFLD...sp.ps.ssIpppLpphhphA+p.pGtAlu.IGHPtsp....Tlps.LpphlspLppcslpLVslS..p.Llp	....................................................................IVIDDhGh...p.pspppl..lul..P.s...lolAllPssPp...uc-hAppA...+ppG+EVllHlPMtPls........t..p..slt.ssLpsphSs-EIp+hlcpAlspVP.aAl..G..lNNH...M....G......SthTushhuMpplh......psLc.ch..s.LaFLDShThuso.Ah.........+hApt.........h........GV.s.lc.R...c.V.FLD...cs.p........stusIcpQhpcAlclA++..pGssIA.IG..HP+.Ps....Tl.c.s.Lpphl.pL.sc..lsLVhsSsLl.s..................	1	98	175	231
+2260	PF04764	DUF613		Protein of unknown function (DUF613)	Waterfield DI, Finn RD	anon	Pfam-B_6084 (release 7.5)	Family	Family of chloroplast proteins of unknown function.  Some members have two copies of the conserved region.	25.00	25.00	91.90	91.90	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.72	0.71	-4.19	10	10	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1	\N	0	12	0	125.70	30	66.12	CHANGED	cYlYRchKccsYWppa.h..lslYVNsK..........+VG.............hscsIo-lEYhLLDlFLaGPLchclo-.YcplpphlpcRsp+Ycchhcc.cplsG.....INIlFs...phsapchLpscYphcEhlssspILplYlls	...........pYhYRc.+ccsYWppa.h..lslYVNsK.....+VG...................hscsIo-lEYhLLDlFLaGPLchclo-.YcplpphlpcRsp+Ycchhcc.cplsG.....INIlFs...phsapchLpscYphcEhlssspILplYll..	0	0	0	0
+2261	PF04751	DUF615		Protein of unknown function (DUF615)	Kerrison ND	anon	DOMO:DM04973;	Family	This family of bacterial proteins has no known function.	25.00	25.00	39.40	39.00	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.90	0.71	-4.58	90	1331	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1309	1	252	777	138	159.20	49	85.34	CHANGED	--...-....hsSKSphKR-hcsLQcLGpcLlsLspspLs+l....PLs-p.LhcAltpAp+l..pppEA+RRQlQaIGKLMRpt....Dh-sIppuL-php..................................spppppstthHplEphRD+Lls.....pss..............sulsphlppaPps.DRQpLRpLlRpApKEttp..........sKs....s..........+uhRcLFphL+c	..............p--.E.haVSKSElKR..DuctLpcLGtELV-LucssLcKl.....PL---..LtsAIchAQRI...cpEuRRRQLQhIG.KhhRpp....DlE...PI...cpALDKL+............................................................N++...s..Qps...shh.....H+LEplRDRLls.....pGD...................sAls-l..lshaPcA..D.....R........QpLRsLIRNAcKE+pt..........................................NKP......P....................KuhRpIFQaL+-...............................................................	0	54	129	196
+2262	PF04765	DUF616		Protein of unknown function (DUF616)	Waterfield DI, Finn RD	anon	Pfam-B_6152 (release 7.5)	Family	Family of uncharacterised proteins.	21.40	21.40	21.60	21.40	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.98	0.70	-5.27	13	242	2009-01-15 18:05:59	2003-04-07 12:59:11	8	14	63	0	143	231	87	269.50	35	55.71	CHANGED	N..........LsYlpt-p..s......t.spFGGp.ShpcRcpSFphppshs.VHCGFh+......psGF-ls-p..................D+thMcpC+.VVVuSuIFusaDpl+pPps..ISchoccsVCFhMFVDEpTLstLcpcssh...hDssthVGlWRlVlV.......+NLPYsDsR+NGKVPKhLsHRLFPsu+YSIWlDuKhcLslDPhLIL-pFLWRpsusaAISpHhcRasVa-EA.AsKRhpKYsc.suIDhQhchYpp-GLpPa..SssKhPlsS...................DVPEGulIlRcHsPhSNLFSCLWFNEV-RFTsRDQLSFAYlh.Kl+s.....saplNMFpsCER+slsh.apH	..........................................................................................t.....................s.FsG..ohtpRppoa..........htts.p.l.CGFhp........tsGac.hsc....................Dh..hppCc...llVuoslFu............s.D.lppP.hs.......hsphoh.p...plC.Fhh..FhD-.o.thhpp.sph.........sttthl.GlW+llll.......+sl.P.a..s.D.R+sGK.....................lPK.hLsHRLFPss+YSIWlDuKlpL..h.s.DP.h.h.lLE.thLW..+..ps..sshAISpHhpRpsla-Euttstph.........pKasp.stl-......QhphYp.p-Gls.a...tsphs.h.s...................tlPEu.ulIl.R..cHs..s..ho..NL.F.sC.L...WFNEVs+.F.T.s..RDQLSFsal..h.+lp.......hth.MF.sCthpthh..hhH.......................	0	25	94	119
+2263	PF04768	DUF619		Protein of unknown function (DUF619)	Kerrison ND	anon	DOMO:DM04985;	Family	This region of unknown function is found at the C-terminus of Neurospora crassa acetylglutamate synthase (amino-acid acetyltransferase, EC: 2.3.1.1) (Swiss:Q12643).  It is also found C-terminal to the amino acid kinase  region (Pfam:PF00696) in some fungal acetylglutamate kinase enzymes.	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.18	0.71	-4.84	33	416	2012-10-02 22:59:21	2003-04-07 12:59:11	8	16	240	39	279	450	57	166.10	28	26.44	CHANGED	sLpKELFTcoGuG.TLlRRGh+lhptsohcph.....................shc+L+sllpcsh....ps+tslspYlcpl.cpp.hpsYss-s..h-ulAIV.....cpss...........................................phshLDKFslocsuhhs.sVuDslFssl.p+-FPp.LhWps+cssss..pWaFs+ScGohp.............csshhlFWYG................lpchsclpphl.......pphsst	.............................................................l.hclFotpuuu.Tll++G.....plhhhsshpph..........................Dhs+Lppllpcsh........tt+hslpcYl.ppl.ppp...hphh....h....sts.........hcusAIlh.....s....t.s............................................hsaLDKFslhcsu.ts.uluD.lassh...+.....ccaPp.L.......hWp...u+p...s.s........sp....tWaFc+usGohp.................psthhhFWhG...................htshpp..phht.h...p..............................	0	85	157	226
+2264	PF01887	SAM_adeno_trans	DUF62;	S-adenosyl-l-methionine hydroxide adenosyltransferase	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [1]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [2]. This family used to be known as DUF62.	25.00	25.00	26.30	26.20	22.70	23.50	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.59	0.70	-5.33	121	1173	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	1120	112	316	783	493	260.10	40	93.36	CHANGED	hIsLhTDFGhpDsaVushKGVIhsl....s.PsspllDlTHplsshslhpuAahLtpshtaFPpsTValuVVDPGVGopR+ulsl....css..s.taaVuPDNGlLoh....lh...........................pth..............tcshclsppp..............................thSsTFHGRDlFAPsA.AtL..ApG.hshpplGptl..............sslsclsh.ps..phps.....s......tlpGpl.lalD+.FGNllTNltsph..........hthuc....phplph..........tttt.............................................hhthscoau...............................clt.Gchl.shhsStGhlElAlsp......GsAuphhulphG..cp.lpl	..................................h.llLQoDFGLpDGAVuAMhGVhhph........s....s...s.l.+IhcLTH-IsPasIacuuYRLhQ.T.ssYW..........Pp..G.T.lFV.SVVDP..G..V.........Go.c.R........+S..llscTt...pspYhVoP..DNGoLoh....lt.c.................phGI..........pplhEIsEhts....h..........................p............cpSaTFHGRDVaAYsG..A+L.....AuG..IsFE..plG..spl..............s.spl.lcLs.h.ps..thpcs.................tlpGsI..Ilss.+.FGslWTsIspc.h........phthphG.c.phpVsIhpts.........................................hatsplsascSFu...............................DV.p...G.pPl..lYlNS.L.h....plulAlNp.......Gu....FuctaplusG..sp...hh...............................	0	118	221	276
+2265	PF04788	DUF620		Protein of unknown function (DUF620)	Waterfield DI, Finn RD	anon	Pfam-B_6213 (release 7.5)	Family	Family of uncharacterised proteins.	20.40	20.40	24.20	25.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.56	0.70	-5.21	20	186	2009-09-10 16:40:51	2003-04-07 12:59:11	7	5	27	0	112	174	1	218.50	52	58.66	CHANGED	MYAhG+V+MsssEhps....ustthsp..........sssus-tGuFVLWQhsP-hWhlELVVu.GsKVsAGSDGKlsWRpTPWls.sHAu+.GPsRPLRRhLQ...............................GLDP+oTAslFusAt....ClGEKtlss-DCFlLKlpss.usLpupSs..ussElI+HslaGYFSQRoGLLlplEDSpLhRlpo..ss..stulaW.........ETohpShlpDYRsVD...Gl.lAHuG+ossolhRF...........G-sstst.spTpMEEtWpI--VsFNV.GLShDsFlPP	.....................hYAhG+V+M....hssEhpt...ustsstt.................sttssE.GsFVLWQhsP-hWhlELsVu.G..s.KlpAGssG+lsW..RpTPWhs.uHAu+.GPsRPLRRhLQ.......................................................GLDPho.TAslFus.Ah....ClGEKplssEDCFlLKLps-stsLcuRSp..ussElIRHslaGYFSQRTGLLVplEDS+LhRIps..su.......s-slaW.........ETThpShlpDYRsVD.....Gl.IAHuG+osVoLhRF.............G-sshsp....s+T+MEEsWsIEEVsFNV.GLShDsFlPP...............................	0	10	64	89
+2266	PF04822	Takusan	DUF622;	Takusan	Mifsud W, Eberhardt R	anon	Pfam-B_3835 (release 7.6)	Family	This domain is named takusan, which is a Japanese word meaning 'many'. Members of this family regulate synaptic activity [1].	25.00	25.00	25.30	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.71	0.72	-4.22	13	539	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	34	0	235	892	0	82.20	37	22.31	CHANGED	sR+TSSpssplocpptc.cclEcLph-l+hIspERsELpchLshahpsshshR......lNspaphL+pp+cph...Mhshcchp.pIh-AhE	............tpsSo.ss..l.ocpppphpclE..cLKhcl+plop-p-EhpsILshah.....cslNhR..............hNsEaphlKpQH-cs...MhDhp+MpppIhpuhp.......	0	1	4	20
+2267	PF04844	Ovate	DUF623;	Transcriptional repressor, ovate	Mifsud W, Eberhardt R	anon	Pfam-B_4487 (release 7.6)	Family	This is a family of transcriptional repressors. In plants, these proteins are important regulators of growth and development [1,2].	25.00	25.00	39.40	38.80	23.70	22.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-8.97	0.72	-4.17	44	411	2009-09-11 05:52:17	2003-04-07 12:59:11	8	6	28	0	276	364	0	60.00	42	21.11	CHANGED	SsDPhpDFRcSMhEMlspptlt.........shscLc-LLtpYLsLNupcpHshIlpAFs-...lhhs..Ltus	.........SpDPhtDFRcSMhEMlspptlt............shc-Lc-LLtsYLsLNup.caHshIlpAFs-...lhhslh.s.............	0	25	150	222
+2268	PF04854	DUF624		Protein of unknown function, DUF624	Mifsud W	anon	Pfam-B_4640 (release 7.6)	Family	This family includes several uncharacterised bacterial proteins.	21.50	21.50	21.60	22.00	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.55	0.72	-4.12	65	1340	2009-09-11 11:23:42	2003-04-07 12:59:11	9	2	753	0	194	770	11	76.80	25	35.89	CHANGED	lshLNlLWlhhs.........................LhGlslhGlhPAosAhaslh++ahpsc....css.lh+sFapsaKcpFhcushlullhhhhshllhlsh	...........................................hhhNlLal..................................................lsulsl..lsl..GsApsulhpshhc..htpsp...........c.....s..........sh+pa....ap.sa....KpNFh.pu.h.lhhhhlslshllhhs...........	0	75	133	155
+2269	PF04776	DUF626		Protein of unknown function (DUF626)	Kerrison ND	anon	Pfam-B_2357 (release 7.6)	Family	Protein of unknown function, currently only identified in Brassicaceae.	25.00	25.00	34.10	33.00	19.00	21.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.85	0.71	-3.76	16	91	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	2	0	85	109	0	106.20	33	38.53	CHANGED	slPca.s-ssh...psp.caY..lccS-lpps.-WlpLYhElslhsp.csp.hppt..lssLcIlpVslcT.ccshpss.c..LpApsAlhYIsa+shsps+.......hGpth.-RtAIlRRhhDtp.uphsL	.................hPcW.s-ssh.....pcp.+aY..lpcSElpps..-WlpLYhElulhsp.cth...hpt......ht.LcIhKVsl-Tpt..pshcsspc..LcApsAlhYIoa+sh.sts..........s.th.-cpAIVRRshDtpsGphpL.........	0	23	23	23
+2270	PF04781	DUF627		Protein of unknown function (DUF627)	Kerrison ND	anon	Pfam-B_2475 (release 7.6)	Family	This family represents the N-terminal region of several plant proteins of unknown function.	20.40	20.40	20.40	20.80	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.12	0.71	-4.45	17	70	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	12	0	49	65	2	113.40	33	10.00	CHANGED	chAcchaspGsaIKALcllEDhIph+tccps.h.hlHhhQGplFhcLApcTE.NsDlKhsYLLuSVpCaScshtLsshs.........AhSLapLuppluSshaYKKslpKAKpuLSlpts.cs	.......cAhshhtcGs+hKALcllcDhlscHt.......csp.....hlHphQGslahclAtps-...ssssKhtaLhuul-shocsstLus.u.........ApuLapLApcht.spaYc+slpcu+cuLSlpss..s.....	0	18	27	31
+2271	PF04780	DUF629		Protein of unknown function (DUF629)	Kerrison ND	anon	Pfam-B_2475 (release 7.6)	Family	This family represents a region of several plant proteins of unknown  function. A C2H2 zinc finger is predicted in this region in some family members, but the spacing between the cysteine residues is not conserved throughout the family.	21.50	21.50	21.70	22.30	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.77	0.70	-5.97	14	139	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	16	0	82	125	0	300.70	25	30.08	CHANGED	cpL+oaWhGLDschKRsFhKVslsKLhoaVpsh....asccsp-sLcpsLs.A+pst+WpFWhC+s.CSc+F.ssE-CKpHl-ppHsucacPspppchsppIscsWActI.SsGsW-PVDssAAlchIKsRltcVKtFs...............YpNGW.................................sc-WPLAsDE..ERuKLLKEI+.lLVthh..-pKlLSCSlRDWlhpaslcaL.tpLcVScpsL.s-spLlcTPQSICFL-sc-LspILcaL+plK.....scRDDGssLVs+uV-uhhcsopVKE+IDhDsphS.hLLLD+RLLpscph......ph.DDEGolssa-ssshYscs.spGDcIlSWLh.DhsplDcp.....FPpsl.....+tHNh-IWlAVLRAVphTsRpLto+YsKKhphlsY-suLstsEslChpEDcRRcsh.c-QhspYASlLs-cCEEhl.c......lssKhFLssV+DVLctAspPsF-hhs.c-C....hshI+phco....lsDD.hVlKSlthL+pllppKV	.........t..h+paWsu.h.s.-p+c.s.FLpVslscLpuahpsh.......tp..pp......stcslscsl..sas+c..sppWpFWhCsh....C.....s......p.+.FhsscphhpHlppcHhs.p......h.......phpp...h.sp..plspt.hchl.....WpPh...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	20	35	52
+2272	PF01889	DUF63		Membrane protein of unknown function DUF63	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Proteins found in Archaebacteria of unknown function. These proteins are probably transmembrane proteins.	25.00	25.00	37.80	34.50	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.79	0.70	-4.32	13	123	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	87	0	88	133	119	269.70	27	93.11	CHANGED	tIp-Fla+YYI-PIht.cpGYNhVNTlTYAlILulslahlY+.hL++L+IclD-+FlhuslPallhGuolRVlpD..uGllpsPhoYlhlTPhIaFLlFslshhsLhluhpl.ptt...t.Yh+laushGlshsllsLhhLl...hppp..lhcsallshll.sluoshssllYhlh+h.h.hshhpc+LshhllhuHhlDASoThlGI-h..l.GYhEpHVVPsaLI-hhGoAhsMaPLKlllllsllYIL-p.htc-....pl+phlhlslllLGLAPGlRsshRMlhGl	..................................h...t..GYs.lsplsYullLhlulhhlhp..llc+......L.cIplD.c.chhhAlhPahlhGuslRslpD.........s........G...........l..........l..PhshLhlTPsIYhslhhls...hssllluhtl.ppt.....ta.p.....h..hhshGslhh.hhsl...h..hLh......hptp....h..hp.h..sh..h..hll..sl..u..sh.hss.lh.....a.hlh+h.........hph...h..p..sh.h.shhllauHhlDusuTslGl-h.......h..G....Y.....hE....pH............sl............sphl............l.........-............h.........h............G............s............ua...s.........hhslKlhlhlsllal..hsc.lp--....phtpllhlslhslGLuPGhRshl+hhhtl......................	0	13	48	72
+2273	PF04816	DUF633		Family of unknown function (DUF633) 	Finn RD	anon	Pfam-B_5077 (release 7.6)	Family	This family of proteins are uncharacterised have no known function.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.37	0.71	-4.98	13	1587	2012-10-10 17:06:42	2003-04-07 12:59:11	7	4	1567	12	231	1139	75	199.30	36	86.45	CHANGED	lsDIGSDHAYLPhaLlpsshsptulAGEVscGPapuAhppVpcssLsc+IpVRluDGLuslcpt-.l.DslsIAGMGGtLItcILEpGpc+Lttlc+LILQPNspt.pLRpWLpppsapIhsEpIlpEcsKhYEIlVsE+upp.......h.osp-lhhGPhLhc-+sslFhpKWppElp+lphlhtpls.....scpsctchptlppcI.phlc-	........................................................................lADIGSDHAYLPlhL.lppshhpp.AlAGEVsp...G...Pap...u...A......hpsV.........p.........t..........p......s.....L.......p..-........c..........IpV...R.Lu....s..GLs....s....l.c.p.........-......l...csIsI..A...GM....GG....p....L....IscI...L-..p.G..t....s........+.L..........s.......s....h..p...+...L..IL..QP..N...h...pp....ppLRpaL.pps.........apIlsEpIlcE.su+hYEIlVs......c..........h..upt..........................ho.pt.-l....hF...G.Ph....Lh.p...p.p.s..s..l..Fh..pKWp+E...lpphpphhpplt.........ppp.......p.....c.ht..tltpcl.t.l........................................................................................	2	89	145	191
+2274	PF04827	Plant_tran	DUF635; 	Plant transposon protein	Kerrison ND	anon	Pfam-B_2859 (release 7.6)	Family	This family contains plant transposases which are putative members of the PIF / Ping-Pong family [1][2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.30	0.71	-4.94	5	275	2012-10-03 01:22:09	2003-04-07 12:59:11	9	11	33	0	143	891	1	132.70	41	47.04	CHANGED	scYL.RuPsAsslcRLLplGc.RGFPtMlGSlDCMHWcWKNCPTAWcGQYTRGcp+.PTIlLEAVASaDLWIWHAFFGsP.GSNNDINVL-pSPlFsDIlpGsAPplpYhVNG+QYNhuYYLADGIYPcWATFVKSIRpPQsEK+KLFApcQEusRKDlERAFGVLQARF+IVtsPu+lWspscLusIMpACIILHNMIVEDERDhs	...........................................................................................................t.................................................................................................................................................tt.Nthp...hlt...s..l..h...............p...G..p...s...s........h..p...a......lN.....tp.........Y..p...h......s.Y.Y.L.s...D..u.I.Y...P..pa..s...s....h......h.....p........o...I.........................P..........s.....t......+......t.p.h.auptQ.Eu....sRKDlEpAFGV.......LQsRatIl.pt....P....s....p.h....a.p.t...tl.t..l...hh...uClIhHNM.IlEDEtt.....................................	0	20	63	102
+2275	PF04828	GFA	DUF636; 	Glutathione-dependent formaldehyde-activating enzyme	Kerrison ND	anon	Pfam-B_2779 (release 7.6)	Family	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.87	0.72	-4.04	59	3736	2009-01-15 18:05:59	2003-04-07 12:59:11	9	25	1139	16	1716	3480	2625	89.40	22	58.89	CHANGED	hhCHCppCp+toG.usass.shhtpp.slp....hhpG...thppap......susshp+.hFCspCGoslah......tsttss.....hhhlthGsl-ps.......pthpPp.hcl.aspp	............................................................................h.hCpCshC........p........+.........t.sG.s....h..hh.shhs......ts....s.lp..................h..h..p.G...t.....plptap.........................................ssptsp....+.....hFCspCGs...lah...........ptpsss..............hht...l.s..h..u.s..l-ss..........p.h.......t......t..............................................	0	364	828	1304
+2276	PF04830	DUF637		Possible hemagglutinin (DUF637)	Kerrison ND	anon	Pfam-B_2732 (release 7.6)	Family	This family represents a conserved region found in a bacterial protein which may be a hemagglutinin or hemolysin.	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.49	0.71	-4.62	30	397	2009-01-15 18:05:59	2003-04-07 12:59:11	8	83	154	0	54	380	8	148.40	36	13.38	CHANGED	ussAu.............l......uuhuosAusuhlsspGshttshK.lspusslKuhssuulTAGlssGl......................s.s......s.ssshs.thstuo.sslspthss.sspushsAulsTAI.pGGSht-...sLtsuh....ssshuAtuAstIGs..................hshssstss+lhsHAhlGCAuutAsGu.........cCtsGAlGAus	.............................................................htsAA.huSLsopAuVuhINNpG.s.......l.upsLK-LupusslKphssushTAGhhsth................................................hh.sshst.o.tth.....s.splssslssus.uuhls..TAl.sG...GS...LcD......NLtsshlusllsshpu-uAspItp............................hspshls+phAHAlsGC....suutsstu..........cCpsGAIGAuV.......	0	18	31	43
+2277	PF04829	PT-VENN	DUF638;	Pre-toxin domain with VENN motif	Kerrison ND, Zhang D, Iyer LM, Aravind L	anon	Pfam-B_2732 (release 7.6)	Family	This family represents a conserved region found in many bacterial porlymorphic toxins which is located before the C-terminal toxin modules [1][2].	20.30	20.30	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.69	0.72	-4.42	32	725	2009-01-15 18:05:59	2003-04-07 12:59:11	8	157	252	0	136	722	0	52.90	36	4.05	CHANGED	sssp...LoEcpKQplosLupLAAGlAuGlsGss........s.sAssGApuucsAVENN.tLu.shps	.............sspLo-ppKppls.uh.up.LsAGlsu....ul.sG.s.s...............tsssuApuucsAVENN.tLs...t.....	0	16	63	98
+2278	PF04842	DUF639		Plant protein of unknown function (DUF639)	Kerrison ND	anon	Pfam-B_6010 (release 7.6)	Family	Plant protein of unknown function.	24.30	24.30	24.70	24.50	23.70	24.20	hmmbuild  -o /dev/null HMM SEED	683	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.16	0.70	-6.37	4	126	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	22	0	82	122	0	514.10	35	90.47	CHANGED	pcht-h....s.ps.sshp.hPc..LS.lANsVVpRCS+hLslosc-LpcpF-sph..ulpp..TauRpFlEaCsF+sLSp.s.phhspLpDtpFpRLhFDMMLAWpsPssssppuh.pt.sp.p.......................h.h.V-cctoVGpEAFsRIAPslPhlADhIss+NLFcsLTouTGp+.Lpa.lYDtYl+pLcKhhKth+oppssphhsh.hucsEhlLch-Gs.sstPVL+Hls.ouWPG+LTLTspALYFEuhslhuh-sshRhDLocD.KpslKPthTGPLGspLFDKAlsYpShsh.EslVhEFsEhpGpsRRDaWLsIlpEllhlHpFlR+a..........plpG.l..t+pEhlu+AlLGIhRlpAlpEhhplsssphKsLL.FsLh-plPtGDhVLEsLA.ph......sphtspRssp..uusthh+.....s.ss.chlspl.G..............s.pstsphtspphlVG.....-hsVu-lssLEpAlcpSRpchchlEtAQATlstlchcGIsoNlAVhKELhLPh..hh..h.plhhWp-PhhossFhhhsohhIaRsWlsallsssLlalAhhMhh....pRph.s+sK..ttlpVps.PspNshEpllulQsulppLEphlQcVNVsLLKlRulhhShhPQtospsAluhlVlAohhAlVPhKYllshshV-hFTRpss.hR+tSs-+hpRRlREWW.plPAAPVhllpsps	..................................st....................h....LS.hAs.slpphu.ph.shsspcL..ppF-.th..t.....s.u..RphlEaCshphL.t....ssp.htsh..LtDttFpRLhashMLAWEsPss..psp..............................................p.hVu.-AFs+luPshshhsDhhssc.hFcsLossost.+.Lpa.hacpYlptlp.+.shcthpt...t..s.t.h......h...p.s.EhlLpltus.sppPVlpa.s.osWPG....+LhLTspALYFEuhtl.hshppshth-Lsp.-..pp.lc.thsGPhGspLFDpAl.hpS.shs-shhhEFs-htuphRRDhWhuhlpEllhha+Flpca............pl.s..h..t+tcshspAh.uIhRhpAlpchhph.ss..cthL.FshhpplPtGDhlLpsLs.p...........t...ptst.......tss...t........s.....t..h...h.h................t.....pttt..h..t.....ph.h.uths.lptultpshpp.chlphspATl-tspl-GlssNlslhpELlhPh..hh..h..lhtW-cPhhohshhhh..hhlh+thl.ahhs..hhh.shhMhh....h+...t.tp..ht.l...l...s.ss.s....shppllslppuhpplEt.......hlQss.NlhLLKhRslhluh.s...........p..........................topphhhhhlshAhhhhhlPh+hllhhhhhp.aTpp....Rp..sc.ph.phh+EhW.pIPssPV.l.....p.................	0	13	46	59
+2280	PF04852	DUF640		Protein of unknown function (DUF640)	Kerrison ND	anon	Pfam-B_6053 (release 7.6)	Family	This family represents a conserved region found in plant  proteins including Resistance protein-like protein (Swiss:O49468).	25.00	25.00	32.40	27.30	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.60	0.71	-3.97	15	226	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	24	0	141	225	0	123.60	63	54.52	CHANGED	ssspsutsuspssss...sh.SRYESQKRRDWNTFsQYL+Nc+PPlsLsp..CuusHVL-FL+Y..........LDQFGKTK.V....HtpuCsaFGpPsPPuPCsCPLRQAWGSLDALIGRLRAAaEE.s.G..GpPE.....sNPFuu+AVRlYLREVR-o	..............................................sssss............ss...s..SRYEuQKRRDWNTFsQYL+NHRPPLsLup..CSGAHVLEFLRY..........LDQFGKTK.V....HstuCsFFGp......Ps......PP.........A........PCsCPLRQAWGSLDALIGRLRAAaEE.s.G..GpPE.......................sNPFuARA..VRlYLREVR-.h...................	0	23	87	111
+2281	PF04862	DUF642		Protein of unknown function (DUF642)	Mifsud W	anon	Pfam-B_4723 (release 7.6)	Domain	This family represents a duplicated conserved region found in a number of uncharacterised plant proteins, potentially in the stem. There is a conserved CGP sequence motif.	27.00	20.00	27.20	20.50	26.70	19.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.21	0.71	-4.58	56	419	2012-10-03 19:46:52	2003-04-07 12:59:11	7	25	70	0	246	418	17	157.70	32	51.47	CHANGED	GLL.NGsFEpuPptuph.puot...lh.GppuIPsWclsGh.VE.YIsuGppp.GsMhLsVPcGsaAVRL...GN-AS..IpQpls.VptGthYolTFuAA..........RTCAQt....EpLsVSVs..s.....p...suslPlQTlYossGWDoYuWuFpA.pp.sslplsh.HNPGhp.-DP......uCGPlIDuVA.IK	.........................sll.NGsFEpuPh.....ssoh..........l..sp.sslPsW...hl...p.u.....h...Vc...YIsusphp...................VPp...GspAVcL..........Gp..Euu......IsQplp..ss.GphYsLoFusu........................csC.sts....p..t.l...s.Vplhs.............p.....stplsh.p...oh.h...s.....s.s..Gacshu.hsFpA..ss..splthh....ps.shp..-Ds......hCGPllDsVtl...................................................	0	35	131	191
+2282	PF04867	DUF643		Protein of unknown function (DUF643)	Kerrison ND	anon	Pfam-B_6086 (release 7.6)	Family	Protein of unknown function found in Borrelia burgdorferi, the Lyme disease spirochete.	25.00	25.00	44.00	67.60	22.90	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.68	0.71	-3.68	3	80	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	22	0	5	64	0	111.60	69	64.24	CHANGED	INEISDFYDNLScclKKE....INKLYtTcQlTLKQK+QhYSuacuhQEYsIKTGKSl-EIls.IIDPsKcFIKDVLKcKaLIKKYKNFpNhKVDaSYKKGMLEKCLEKLGEccShtF	.......INEISDFYDsLS.sTKKE....IsKLYGscQLTLcQK+chYpuahuIQEYKRKTGKSI-EIls.IlD.PAKpFIKDVLKDK....aIIEKYKNFQNhKhDhSYKKGMLEKCLEKhGEchSscF........	0	5	5	5
+2283	PF04870	Moulting_cycle	DUF644;	Moulting cycle	Mifsud W, Eberhardt R	anon	Pfam-B_4889 (release 7.6)	Family	This family of proteins plays a role in the moulting cycle of nematodes, which involves the synthesis of a new collagen-rich cuticle underneath the existing cuticle and the subsequent removal of the old cuticle [1].	22.00	22.00	22.10	22.40	21.30	21.90	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.08	0.70	-5.36	9	114	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	9	0	113	89	0	257.80	25	45.59	CHANGED	PhuhIsKpLpphV+shKpK..-..pKWp-llp+Ipccspcl+p+Kptcph.Rp.hth...t.............ht.ph........hps..h-phl-D--ltphhtp........ho-c-chhhhPhclIRpAsKLGhslsG..pNsosF-pKpl+lhSPRFMSllP-cptt..sslsLLSPSlFSLHc-Go-.EpphSlsplL.tuhhsssDppsal-hllEAoGVsEsV--Ac+chhptphccpct.hhs.cGp.h.Fo+pNhocta.sscspKl-lhEpLcKoYStpQhc-MNpTGYolhsscQMphhYGctSPapNsc..hLcsY+Nho+u-hcculassI+slAccch...KFc	.............................................................................................................................................................................p.p......p.W.phh.ph.p..t.h..ppp.pp..p....................................................................ht...h-....ht......p.........................................tt.p.h..P....thlcp...............uh.ch.h..h..s..G.....ppssshs...hphlSPRhhulhP-p.......................s.phslLSPSlhuLac...c.sst.-phhsLspll.....phhp...pp-ppshlshlhEhoGlscsl-ch.ph.h......p..p........s........h.p.pp..thh...ptpphchhctLppoho.c...............Q...hpchpppGashhs.pQhphlYGptu.hpssp...................lcphpphoptp..hpptl.psI+tlAptp................................	0	39	53	113
+2284	PF04875	DUF645		Protein of unknown function, DUF645	Mifsud W, Eberhardt R, Haft D	anon	Pfam-B_4997 (release 7.6)	Family	This family includes several uncharacterised proteins from Vibrio cholerae. There is some doubt regarding the existence of these proteins, they are encoded by open reading frames contained within a repeated region in the Vibrio superintegron.	19.80	19.80	20.30	20.20	17.40	19.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.94	0.72	-4.28	12	607	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	63	0	14	247	1	51.60	66	95.40	CHANGED	lLDspHsphuFhKGCIIusIhlSLSRTLNpGQLNLDRFcFWQPTSQLLsLDVCLhDAFA	...........h.sh.ptphuFhKusIIsshhlSLSRTLNRGQLsL-RF-FWQPTSQLLsLDVCLhDAFA........................	0	13	13	14
+2285	PF04883	HK97-gp10_like	DUF646;	Bacteriophage HK97-gp10, putative tail-component	Kerrison ND	anon	Pfam-B_6160 (release 7.6)	Family	This family of proteins is found in the caudovirales.  It may be a tail component.	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.80	0.72	-3.05	172	1665	2012-10-01 19:49:39	2003-04-07 12:59:11	7	3	1229	0	221	1184	106	85.30	19	61.94	CHANGED	ccltcplpp.htp..........hpcth.ccslc.psuppl....tpphpppsP......................p............s.Gp......lpcShph...................................................ttps..st.hplpltsssp.....................Y...AphlEaG	........................................................tl.pplpp.hsp......p.hp.chh.ccslp..psuphl......hpphpppsP................................................hc........o.Gp..........Lccslph.................................t.......................ptps.....st..hs..spl...ts.sst...................................................Y....spalEhG...................................................................	0	74	152	185
+2286	PF04890	DUF648		Family of unknown function (DUF648) 	Finn RD	anon	Pfam-B_5530 (release 7.6)	Family	Family of hypothetical Chlamydia proteins.  This family may well comprise of two domains, as some members only match the N-terminus. 	26.60	26.60	27.80	26.80	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.04	0.70	-5.26	8	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	15	0	21	58	0	213.60	23	66.45	CHANGED	Mpl...YoFSP.slpsSapc+lhAsLDuYFFLGG+RhKVlolsspsshphhuppcshslSTsEKlLKILSa.LLlPIVIIALLlRhhLHppa+tph.sh.hL-st............spsl.................ph-l.tpstcsushhsh.s...........htppPpslctshhhsctpF.sshppcahhchho.....shltYllu.ppphpshsl...............cs..hp.oscshppph-hsh+scp+sl.......pcLcchLshsu..Khop.schlpptlhculpp...........sPpFh.-hscchhspLssss.Ishc.............................................tG.pssphpthtshhlhhp.....phth	....................hthSs...psoh.c+hhutLDsaFahGGcp.spllshss.tthh.hhpp...pshtl...SphEKllKI.lSa..lllPlsl...lALllRhhLH....thhphph..................................................................................................................................................................................................................................................................................................................................................................h.........................................................................................................................................................................	0	1	1	19
+2287	PF04894	DUF650		Archaeal protein of unknown function (DUF650)	Kerrison ND	anon	Pfam-B_6199 (release 7.6)	Family	This family represents the amino terminal region of an archaeal protein of unknown function.	25.00	25.00	54.00	31.10	16.90	15.20	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.65	0.70	-4.92	36	192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	147	0	121	190	40	262.30	35	66.52	CHANGED	hLCGhshCPILp+hcshpthhpphppt.....l.GuSPPSlFVGchGYP+VplsPhsPP.lpGDsu.h.a-sPppWhs..hslc-llphRsuLlputtphpVc...............pts.sthlpclQplAlSs+PV-sEhthp+h.Pphc...lhhDthhsPhGPuushcphclspNP+lP+plE+lhhD.Dh+Ac-AlhpLYcpGhslhpIp+lLSsGhLG..ccR+LVPTRWSITAVDchluchLhccl+passIsphcVahppahGNpahllLhPupasaEhlEhWhPsSlWs	.....................LCGhshCPIlt+hcshh.....ph.....h.ph...httt.....p...l.GSoPPSlFVGchGYP+VplGPhhPP..htGDsu..h..h-sPppWhs..hslc-IlphRhsLlputpp.h.pVc....................ph..sthlpclpplulSs+PVDsEltlp+h.Pp.st...lhh.sthhsPhGPpu.lcchclspNPplP+tl-+lhtD.Dl+Ap-AlhpLYpp.GhDlhpIp+hLSsGhLG..cpR+LVPTRWSITAVDchluctLhc.cl+paspls.chcVahtpahGNhahllLhPs.papaEhlEhWhstohWs...................	0	32	71	99
+2288	PF04895	DUF651		Archaeal protein of unknown function (DUF651)	Kerrison ND	anon	Pfam-B_6199 (release 7.6)	Family	This family represents the carboxy terminal region of an archaeal protein of unknown function.	20.50	20.50	20.90	21.10	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.37	0.72	-4.43	41	188	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	147	0	119	186	25	106.70	36	26.66	CHANGED	EshcG+psY.spluGuYYAARLuVhEaLpcp+RQAssllhREIpssYasPVGVW.VREsVRcAhcscP.tpF-oLc-Alphlspp..lchshppahtpSpllpth...pQpoLssF	...........EshpG+psY..spluGuYYAARLuVLEaLpph+RQAsslllRElpssYhsPlGVWplREsVRpAhc..........s...........ps.tpa-.slcpAlphlspp..Lphs..hppahppSpllpth....Qppltpa.............................	1	31	69	98
+2289	PF04910	Tcf25	DUF654;	Transcriptional repressor TCF25	Mifsud W, Eberhardt R	anon	Pfam-B_6652 (release 7.6)	Family	Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions [1].	20.10	20.10	20.10	20.30	20.00	18.60	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.07	0.70	-5.51	44	359	2012-10-11 20:00:59	2003-04-07 12:59:11	9	8	293	0	251	376	8	304.20	28	48.74	CHANGED	a..FpFp..asppYppspppFhhslphh.Dspslhpll.pphPYHlsoLLQluplhchpu.Dpshus-LlERALash-psh+ssF.....shss.ups+Lsapp.pNRtFaLsLa+alttLspRGsacTAhEasKLLLSLsPsp.DPhuhhhhIDahAL+ucpapaL....lchhp..........p.hh......pp....................................................................................................................................................................................ht..............hP...........................shuaShALAhht.............Lpcp........................................................................ppucthLppAhttaPhslhtLhc..................pl.................shs.hs...thtspss.tsh.......phhsclYltRsptlWcsspshpaLcpsht......................................ph..pt...tpshtt.....ppsht..pshshslhRallLSc......pphhshlP......pplh..tt.h.t.DP..LPP	.........................................ata...asptYppsptpFhhs.l..pth.Dsptlh....tl...L..pptPYHlsoLLQluclhchpt.-tthus-LlERAL..ashppuhps.F............phsp.GpsRLsapp.p......NR..thalsla+aht.Ltp+GshRTAhEasKLlL.SL-Pp..........DPhshhhhIDahAL+u.cpa...p.al....lchhp.............................phth...........pp.....................................................................................................................................................................................................ht....................................hP........................................Nhsa...ShsLAhhh.............lppp.............................................................................................................ppu.pthLppAhhhaPhlhh.Lhp...................ph........................................sht.hs....h.hsp.s.s....sh..........phls.plYltRst.lW.pp.sphhsaLppsh..................................................................tp.t.....t.hsh.slhRalhLo-.....hpph.h.shlP.....phh...t.....D.lPP..........................................................	0	90	142	209
+2290	PF04919	DUF655		Protein of unknown function (DUF655)	Mifsud W, Bateman A	anon	Pfam-B_6697 (release 7.6)	Family	This family includes several uncharacterised archaeal proteins. This protein appears to contain two HHH motifs.	22.20	22.20	22.20	22.30	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.05	0.71	-4.57	8	157	2012-10-03 02:11:09	2003-04-07 12:59:11	7	2	154	1	102	214	123	176.80	41	87.79	CHANGED	hE-YAaVLDYLPpGaPD-cp..a+ccPlsQulGEcpFpLLEloP+..ssDlh.....................................................................................lh-+VaIGKGp..RcKIsplsR.+lpY-DLTssA+sELPYVlE-IV+ppE-RFVcFFNcApPIosRLHsLELLPGIGKKhMWsILEERc+K.PFESFEDlcpRVculpcPs+lIscRIlcEl......csc.ppKYhlFVt	.........................................................................................................................h.EcaAhVLDaLs.....hGh.....s..s-p....+........a..p..cc.P..lsQulG-ctFpLlElssc...ssslp.....................................................................................lt-+lalGpsp..Rc+l.plt+.......+lpY--LTssA+sELshllccIVcppE.c+FVcFFNcAt..PIT...h...RLHsLELLPGIGKKhhhpIL-ERc++.PFcSFcDlccRlt....ulp.cPschlscRIlcEl..........psp..pKYhLFs.h.................................	0	27	61	83
+2291	PF04920	DUF656		Family of unknown function (DUF656) 	Finn RD	anon	Pfam-B_5777 (release 7.6)	Family	A family of hypothetical proteins from Beet necrotic yellow vein virus.	25.00	25.00	27.00	31.60	19.90	17.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.60	0.71	-4.43	2	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	4	0	0	37	0	123.70	89	45.88	CHANGED	MADsEICRCQsop.PLlphpsYDhTuRhh.cRI-IGPLGVLhNlshLFHMShlR+hDlaPaLNpIhSIsVSlDVPs.uslsssplhVhlahsp.........Wphl..C.....CasusclhSD.L	......MADGEICRCQVTDPPLIRHEDYDCTARMVQKRIEIGPLGVLLNLNMLFHMSRVRHhDVYPYLNNIMSISVSLDVPVSSGVGVGRVRVLIFTTSRERVGIFHGWQVVPGCFLNAPCYSGVDVLSDEL	0	0	0	0
+2293	PF04936	DUF658		Protein of unknown function (DUF658)	Moxon SJ	anon	Pfam-B_5062 (release 7.6)	Family	Protein of unknown function found in Lactococcus lactis bacteriophages.	22.30	22.30	22.30	23.90	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.28	0.71	-4.44	2	26	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	17	0	4	20	4	142.50	57	91.62	CHANGED	KlaDsYhpG.KhuTGThcEluchh.lS.pSluhWlKNGhssp.tNsthKhAllNc...KthME.......KhP.........G.h.hsGotpcISp....................................................Ehp-+-RRKHETKEERRLRRNIRAQMAIEsuRKE-.sh	....................KlaDsYhpG.KpuTGThcEluchatlShsSlulWlKNG+ssp+AsstYKHAI.LNcEpoKElhE.pKpEt+K.LPtuVYshYccGphlhTGTAcEISQhhpItppsVa.YlpsGKhsachhKphK+AlhNpsETRKRFPhhSh.pEcE...lEpp-K-RRKHETKEERRLRRNIRAQMAIEsuRK--.sh.....	0	4	4	4
+2294	PF04937	DUF659		Protein of unknown function (DUF 659)	Moxon SJ	anon	Pfam-B_5061 (release 7.6)	Family	Transposase-like protein with no known function.	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.77	0.71	-4.73	15	467	2009-01-15 18:05:59	2003-04-07 12:59:11	10	41	39	0	216	514	3	121.70	28	21.63	CHANGED	PohcsL+spLLpcthp-lpphl+-hKssWptTGCSIluDsWpDscu+sllsFlVsCPcGshFLKSlDsSs..hhpssphLhcLlsplV-EVGscNVVQVITcssssYtuA.GKhLhp+a..solFWoPCAu+ClclhLE-lu..K.........lcals-slccAppIT	......................................................................................h...h.t.h.....hp.....t.h....G.so...lh.sDsW..ss.....pt+.sl.h.N.hhs..s...t.u.h.h..F.hpu.l.-sos...........css...phlhphhcp.hl....c..c....l....G......p...N..VVQl...l...T...DNsss.h...htu.sph..l.tch...pl.aW..ssCssHslsLhlc-hs..p.................h..htph.ltpu..............................................	0	24	135	186
+2296	PF04939	RRS1	DUF660; 	Ribosome biogenesis regulatory protein (RRS1)	Finn RD, Moxon SJ	anon	Pfam-B_6906 (release 7.6)	Family	This family consists of several eukaryotic ribosome biogenesis regulatory (RRS1) proteins. RRS1 is a nuclear protein that is essential for the maturation of 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae [1].	25.00	25.00	30.50	26.30	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.16	0.71	-4.76	33	347	2009-09-10 22:34:59	2003-04-07 12:59:11	7	6	299	0	237	343	3	161.40	38	57.87	CHANGED	hshpaDLGpLhuhDsNsl........ssssppEptLpshsRDs...sQlLlNplhs...L.Ptcss.s-u...........sllpLPpPsohL.PREKPlP+PK.s.TKWEpFAccKGI..............pK+++s+hVaDEsos-Wss+WGYKttNc.ct-c.pWllEV............sstctstDshttpctc+Kc+lpKNchpch+Nht	...............................................hphDLGpLhuh...DsNsl...........t.tsshEp.LpshsRDs...sQhLlNplhp...L.Phpps..p-u................hlhpLPt....P....sT..........h..L...PREKPlP.cPK...s.TKWEpFAppKGI..............pKc++s+hVaDEtstcWhs+WGY..Ktt......s...ctcc..pWllEV............................tss..c....h...pD.h..scp..cpp+Kc+ltKNEhpph+Nh.h................................	0	88	139	200
+2298	PF04978	DUF664		Protein of unknown function (DUF664)	Moxon SJ	anon	Pfam-B_5281 (release 7.6)	Family	This family is commonly found in Streptomyces coelicolor and is of unknown  function. These proteins contain several conserved histidines at their N-terminus that may form a metal binding site.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.85	0.71	-3.97	48	958	2012-10-02 14:44:17	2003-04-07 12:59:11	7	6	365	1	344	2013	90	150.30	24	84.39	CHANGED	sLtuaLctpRpslhhplcGLo-cph+ppssssus..oLhGL...........l+Hlu.pVE+sWhppshssp.sss.h..............ssssscat..hsss-ohssllutacpssspucthlu.thsLDsshsh.....tshht.....sol.RalllHhlcEhARHsGHADllREtlDG	...................................................................LhshLsttRt.sl..htpscGLoscphcp....t......s....ss..u.....s....ol.....suL..............l+.Hl...A...t...l...........E...........p....s...........W..h...t.t...s...h...t...sc....ts.h..t..h...ht........................tthst.shp.......h.s...p....s...c.....s..h...s......p...l.....l...s...t.a.pps.s...p.c.s..p..p.hl.t......t..h..s...h.-.ths.ph..s........hshtss........sol.c.hll.l.H..l.l.c.-tupH.sGp....A.D.llREhl........................................................................................................	0	134	276	327
+2300	PF05006	DUF666		Protein of unknown function (DUF666)	Moxon SJ	anon	Pfam-B_5319 (release 7.6)	Family	This family contains several uncharacterised viral proteins.	22.20	22.20	22.20	27.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.19	0.71	-4.22	25	69	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	65	0	0	67	0	150.20	43	75.16	CHANGED	FpR.sslVDC.s.po+LPCVTDpQChDNChss.hh...sshpCpp.GFCsspss.lsu.ps.s.....CDtshGLlpVasA.u-FVVsphClSsYRDllDDsGplRPYlC.......ssGsLclcLpsp.FoscDChCssGYT+hhFsQsAhuRslPVCIPNphAsLYsRlY	......FpR.sshVDCsps..+LPCVoDpQChDNCshtshh...sthsCps..GFCsspsu.hsutts...sth-CDsshGLlcVasA.u-..F.V.VsphClSTYRDll...DDsGp.RPYlC.......ssGsl....s.lsLtsp.Fo.sscCpCssGasKhlFpQTAhARolPVCIPNphuslYs+lY......................................................	1	0	0	0
+2301	PF05018	DUF667		Protein of unknown function (DUF667)	Bateman A	anon	Bateman A	Family	This family of proteins are highly conserved in eukaryotes. Some proteins in the family are annotated as transcription factors. However, there is currently no support for this in the literature.	19.70	19.70	19.80	20.20	19.20	19.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.14	0.71	-5.07	9	406	2009-01-15 18:05:59	2003-04-07 12:59:11	8	22	162	0	285	362	9	167.50	41	37.28	CHANGED	MFRssaQsG.FLolLhSsGSKPLpIWchpsKNGalKRlTDc-I+ShVLEIhGsNVuToaIssPssP.ppoLuIKLPFLVh.llKNh+KYFoFElQIlDD+ph+RRFRsSNaQSsTRVcsFhssMPhpLssG.WNQIQFNLuDFTRRAYGTNYlETlR.lQIHANsRIRRlYFsD+LYs-DElPs-a+LasPh+sp	.............................................ptaQts.Flslhhu.hG......p..........p..PlphWcp...psc.s..G.cl+...........+lhDp-lp.S..VlEI.G....sssuosaIp..sP.....t....cs.....pp.........o.........LGI+hPFLlh...llK..s..................h..p.KY...Fo..F.Elplh..DDcsl+RRFphS..Na.....p..pp....s............+l.......p......P...h.hsp.......h................P......h..p...............l........s...............p.............G....WNplQhN....Ls.DaT.......c.c..u.Yu.....o....s..Y...h..coL+....l.plpANCRlRRlYFuDplYs.pp-lP.ch.+h.......p...........................................................................	0	118	162	232
+2302	PF05003	DUF668		Protein of unknown function (DUF668)	Moxon SJ	anon	Pfam-B_4700 (release 7.6)	Family	Uncharacterised plant protein.	20.90	20.90	21.00	20.90	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.14	0.72	-3.77	18	204	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	22	0	131	194	0	88.20	43	17.08	CHANGED	TLGuAuLALHYANlIlhIE+Ll..........ss..sptlstcuRD-LYpMLPsolRsuLRu+L+shs+s............DtsLAspW+sshp+ILcWLuPhA+NhlR	.......pLGuAuLALHYANlIl.I-pll...................sp...sphls.ssRDsLYphLPsol+u.uLRu+L+shshs..................-thhssph+sshp+.hLpWLsPlApNTh+..	1	11	80	109
+2303	PF05037	DUF669		Protein of unknown function (DUF669)	Moxon SJ, Sammut SJ	anon	Pfam-B_5014 (release 7.7)	Family	Members of this family are found in various phage proteins.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.85	0.71	-4.28	22	204	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	181	0	29	185	46	130.70	19	77.97	CHANGED	hFThDasps....psapsl.sGpYcVhl..psphpsscs.Gsphlplchclhss..........papsphla.c.hh....ppcsschs.ttLpsls+AhG...h.pspphpslcsahpphhs+sl+Vslchc..sE.NGppY...plhth..scs..Ptst	...................s.pps.....pthtsl.sGpY-l..hlp..psphpsocs......G.sph...lslphplcss............ca.p.spplahphhh............pppstchshttl.thstsht...........h..ptpphpshpph.......hp.th....s+.hplhlp.p...p.pup.h...p.................t.....................................................................................................	1	15	25	28
+2305	PF05050	Methyltransf_21	DUF672;	Methyltransferase FkbM domain	Moxon SJ	anon	Pfam-B_5811 (release 7.7)	Family	This family has members from bacteria to human, and appears to be a methyltransferase.	18.30	18.10	18.30	18.10	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.82	0.71	-4.31	459	2587	2012-10-10 17:06:42	2003-04-07 12:59:11	7	106	1140	1	1157	2771	5093	161.90	17	45.41	CHANGED	DlGAsh.....G...................hhh.h......h..sshl...hs.......hEPtst...................thpthttt..........................hu.....ls...............................................t..t.hphhhhsh............t.ht.thhtst......t........ttttt....................t...............................ttphplpshsL................D..sh.hpph..............ths.....h....lKlDlEGtE...hp..lL.......s...spphl.pp...htshh...............lE.....h..................................thpplhp......hl.....pph........GYph	...........................................................................................................................................................DlGAph.......G.............................................hh...........h...tspl....hu.......................hEPtst....................hthlptp...........................hs...........ls...t.............................................................................................t..t....hphh...h..sh.t..............tth.h.....h.htt....t..shtt...........................................................ttspthplpshsL......................................................D.......sh..hpph............tpls........h...lKlDlEG....tE.....hp....lL..........pG......spphl..pp.....hpshh............h.hE......hp.......................................tt.hht...hl..........th..sa.................................................................................................	2	476	817	1040
+2306	PF05054	DUF673		Protein of unknown function (DUF673)	Moxon SJ	anon	Pfam-B_5918 (release 7.7)	Family	Family of uncharacterised viral proteins.	25.00	25.00	37.30	36.30	17.40	16.60	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.30	0.70	-5.88	23	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	0	58	0	355.70	43	99.39	CHANGED	MsCPhsI+VhISDpFlhFPYchVtsQsshus.....t.lpsLsVYVPTpEDlphls+pph..sp.FcsVhVh+Hc...sph-scsstcsssuslVYWNPIhPIsclG.lGpTpVFSVlLTssLa.Csohhlcpsssh...CPlQh....p.......................h.....phschsslsGEss..Ltphsplhcss.ssFlICFs+ETPphlKI.LNlKRlLhlhu.hRps.A+Ysl.LscpElssIapcLsWEpsRRLhKGs.hssp...C.shlNRsSLpYl+pA.-lLsIsssu.polhshlchFpsLIlsYplVP-lhlcLNslspp...........K+..VRLYC+sDShAITstGsVP.NhPssNsh.sFcasslssssh.pphppclhpcs...s.lhlpuscYNYFh	........................................................MsCP.hsI+VhISD+FhsFPYphVpPQsDlGs.....t.l.psLlVYVPT...--DlpaV-Kpth......sp..FpoVhVh+HE..ssph-ocsscKsssuTlVYWNPIlPIsElG.sGcTcVFSVLLTssLFhCpThllcppsPh.....CPIphp..........................p....hphpchhPIsGEhP..Ltchpclh-ss.ssFLIC..FshETPphlKI....LNlKRlLslhp.aRcsPA+YsIpLscpElsslYpcLsWEpsRRLh.K.......GD..hssp...C.shlNRsSLpYl+pAppLLtIscsS.polVcFVphFpsLIhPYplVP-lllKLNolcpp...........++..VRLYCKNDShAITshGsVPsNhP-pNPh..sFDaoDlsssptlpphtpclhpcs.hss.lhVpAs+YNYFh.........................	0	0	0	0
+2307	PF05056	DUF674		Protein of unknown function (DUF674)	Moxon SJ	anon	Pfam-B_5937 (release 7.7)	Family	This family is found in Arabidopsis thaliana and contains several uncharacterised proteins.	23.20	23.20	23.20	23.30	21.50	23.10	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.82	0.70	-5.86	8	313	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	19	0	190	294	0	209.90	21	83.65	CHANGED	MAcSoccPKlSLRLlIDEEKNKVVLAEAG+DFVDlLFShLTLPMGTIVRLLEcH.+KSpslsIGCFsNLY+SVV-MulDsFcT-ACKQMLLYP+Sl+cppsRsLKLNIDDTEusKhFhCPtF..pttCpchYSNFsTS+CcCGsh.........MNcEIph.cptts.uphts..DssGVFsps..+oSFlITDDLKVplsSscllLNsLKDLGhuDs.sKLsEhll-VGlcE............................VhTLLpClFTS-sPLTDTFL+K+S..o.sspRhaKt.SPslpcpt-EussDpslTLcsaVRKpD.hcILYVECGEDFVDLLFTFLAlPLESlWpISG....suIslGCIGNLhRSFKDLS...sstsppus..KCslPaYYpCQKQLL..slhTppPPsYhtah...ths...patLopp........pc+lpphhhhDPKocsphpStstp.....GFVK+sTKFhVoDDLIITPhNSsSTlslLK.chQlchDDlElQsIoIuKsE	...............................................................h...........hphhhppp..tpplhhhEuttchl-hlhs.hh.hPhuthhp..hh...................................................................................................................................................................................................................................................................................................................................................................................................................ahl.ssh..h......s........h.......th.t....h.p..h.hs...tc............................hh...h...L...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	15	106	142
+2308	PF05055	DUF677		Protein of unknown function (DUF677)	Moxon SJ	anon	Pfam-B_5920 (release 7.7)	Family	This family consists of AT14A like proteins from Arabidopsis thaliana. At14a has a small domain that has sequence similarities to integrins from fungi, insects and humans. Transcripts of At14a are found in all  Arabidopsis tissues and localises partly to the plasma membrane [1].	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.87	0.70	-5.77	7	135	2012-10-01 23:20:42	2003-04-07 12:59:11	7	4	17	0	109	163	0	266.10	27	77.09	CHANGED	L+SFDosLppRTsplIsSLsspsc.......spSls...hDuLhElsppLlEhNQsVs+lIl-.c-.DlWcNp-LhpLVpsYFcoopKTLDhCpslEpClc+Achup.LlIphAltQFEpEsh-ps.G...cp++YcKTLEEL+pFKshGsPFsG-........Fhs.FcplacpQhhhLEcLc+p+cKLDK+L+Nl.......+shRhlSNllFssAFlsVhlhSlVssuhusssssu.lAuuhssPltuhGhWss.........phWcK.EculK+p+plhpoM-tGh.ss.cshcsIphhVcpLcscIpShLcss-FAl-+cp...us+luhppIcK+l-thTcplcElG-psuppS+hIthuRhllLp+I	...........................................................................................................................................................................................................pl.tLl.pYFp.o.ps.phCttl.pslppsc.p....l..hlt.....h.....tp.................................t.h.t.hhpt.L...tpF..htsP.Fst.................ht.Fptlh.ppp.t.hlc+Lptp+++lc++l+.l.......+thp+s...Sslh..hssshs.s...lhl...sullhAs..h.s.hsslhs..hsuhhu.h.P.htsh.upahs.................phh.p.p.hpp..slp.t.t..p......phls.sh...t...tGTalhhcDh-.....oIphLVs+Lcscl-...shhphschulcp....pc...........s......lc....s.....l.c....cl+K..p.ps....Fhcpl--Lt-psthC.tsIp+ARtlVlpcI....................	0	17	65	82
+2309	PF05077	DUF678		Protein of unknown function (DUF678)	Moxon SJ	anon	Pfam-B_6127 (release 7.7)	Family	This family contains several poxvirus proteins of unknown function.	21.50	21.50	21.70	56.20	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.90	0.72	-3.99	10	55	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	35	0	75.10	63	95.94	CHANGED	hDsu...GGtKR.RKRKP+T..oVc-p.......DDCsTCSSCpSKLVplSDlTKlSLspaplsGK...usTLoCuACGSpLphLsDFs	......DST..tuGhKp.RKKKPKT..TVhD-.......DDCMTCSuCQSKLVKISDITKVSLDhlssh.+....GNTLuCuACGSSL+LLNDFA..	0	0	0	0
+2310	PF05078	DUF679		Protein of unknown function (DUF679)	Moxon SJ	anon	Pfam-B_6129 (release 7.7)	Family	This family contains several uncharacterised plant proteins.	25.00	25.00	33.00	27.10	21.20	17.60	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.20	0.71	-4.60	24	212	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	23	0	125	191	0	154.50	40	74.00	CHANGED	hsusAsLupLLPTGTVLAFQhLuPsFTNp.GpCss..sN+hLTusLlulCuhSChhhSFTDShhs..t.cG.+laYGlAT.......h+G.lhlhs...............................................................uusssspp...........chp+YRLRhlDaVHAhhSslVFhuVAhh.DtslssCaa.Pssupss.....+clLpslPlulGhluShlFhlFPosR+GIGa	.......................pusupLspLLPTGTlLsFphL..sP.hT..Np.GpCts...ss+hlousLlslCuhuChhh..oFTDSap.s.....t..cG.plaYGlAT.......h.cG.lhshs................................................................t..th...................phscY+L+hhDFlHAhhSllVFhulAhh.DtslssCaa.Ps..s.tpt.....cpllpslPlslGhlsShlFhlFPopR+GIGa...............	0	12	64	94
+2311	PF05079	DUF680		Protein of unknown function (DUF680)	Moxon SJ	anon	Pfam-B_6131 (release 7.7)	Family	This family contains several uncharacterised proteins which seem to be found exclusively in Rhizobium loti.	21.70	21.70	23.10	22.70	20.80	20.10	hmmbuild  --amino -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.92	0.72	-3.48	10	44	2009-09-11 14:48:27	2003-04-07 12:59:11	7	1	5	0	29	44	0	52.80	42	70.12	CHANGED	GSDsaGSsssNQPAAo.......stVDsotTASlcK....h.t...ossssps...psuQGs.........c.slaGp	......GSDpYGSsssNQPAAo........tlDsotTuSlcK...........ossssps............tssQGs.........chslaGp..	0	0	10	10
+2312	PF05080	DUF681		Protein of unknown function (DUF681)	Moxon SJ	anon	Pfam-B_6137 (release 7.7)	Family	This family contains several uncharacterised beak and feather disease virus proteins.	25.00	25.00	72.90	71.80	18.00	17.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.47	0.72	-3.57	2	31	2009-09-11 14:24:40	2003-04-07 12:59:11	7	1	1	0	0	31	0	88.90	84	58.80	CHANGED	MGGAChs.+YWLVPs+Vh.Rh+.T.hTu.RGVARsDGPMsSLs.NhIKCAVsGGMDMhGKhSSShTT.MGG.LIARCSA.hTVTHI+CQLRA.LWSL.ARG	..MGGACIsSRYWLsPAHVhSRh+.TSSTsHRGVARVDGPMsSLGLNIIKCAVNGGMDMMGKhSShWTTFMGGYLIARCSASATVTHIKCQLRAhLWSLPARG	0	0	0	0
+2313	PF05081	DUF682		Protein of unknown function (DUF682)	Moxon SJ	anon	Pfam-B_6152 (release 7.7)	Family	This family consists if several uncharacterised baculovirus proteins.	25.00	25.00	29.80	29.40	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.97	0.71	-4.67	16	57	2009-09-11 12:02:38	2003-04-07 12:59:11	7	1	55	0	0	51	0	147.80	46	94.26	CHANGED	p+TI.LYLsc..Pssls....sDKssDcsVlYF-GlIEslsDcSCDKhohFuELKKEcALhMKKshpDLlp+ssGNYsKNHVLlDALlMYKTYVELl..D-SAFGtslLphCh-alTthF+LFpLpS+IlVllPspssacpDNLSsLLKHLhphslIpl	..........................+TlhLYLsc..P.s.slp....sDpssDc..shlYFEuIlEClsDcoCDKhohFuELK+EpALhMKKhhpDLlp+ssGsYsKsHVLlDsLlMYKTYV-Ls..D..-SAFGpsllph.C.palTtlFcLFpLpS+IlVllP.pls.acpDNLSsLLKHLhphslIpI..	0	0	0	0
+2314	PF05082	Rop-like	DUF683;	Rop-like	Moxon SJ, Eberhardt R	anon	Pfam-B_6161 (release 7.7)	Family	This family contains several uncharacterised bacterial proteins. These proteins are found in nitrogen fixation operons so are likely to play some role in this process. They consist of two alpha helices which are joined by a four residue linker. The helices form an antiparallel bundle and cross towards their termini. They are likely to form a rod-like dimer [1]. They have structural similarity to the regulatory protein Rop, Pfam:PF01815.	21.10	21.10	21.50	27.10	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.25	0.72	-4.50	32	142	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	135	4	75	130	7	64.10	40	88.76	CHANGED	hs-.lcpLKtclKKLsu+AsphKMDLHDLuE-.LPssWppIh-lAp+Ta-sascLsph+ppLtshEsu	.......p-lcpLKtcl+KLsu+AsphKM-LHDLuE-.LPssWppIhplApcsa-AatpLspt+ppLtthct.t...............	1	17	47	60
+2315	PF05075	DUF684		Protein of unknown function (DUF684)	Moxon SJ, Pollington J	anon	Pfam-B_6081 (release 7.7)	Family	This family contains several uncharacterised proteins from Caenorhabditis elegans. The GO annotation suggests that the protein is involved in nematode larval development and has a positive regulation on growth rate.	25.00	25.00	26.20	26.00	23.20	24.30	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.22	0.70	-5.84	5	141	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	6	0	141	123	0	248.80	21	75.10	CHANGED	LcKLtELcKcIc+LS-sMsucF-DLKAFIlspEFY...................sslAsTAsTLMKaMQDTsssPsKco+cs....F+-sssKsSPLcLAcpLhphL-sEsTNPLKMAMsADsL+sccTFEKWRcIIDAVlTQhLlLEoFtNGha+D+spYcPc+LsEchcEacEphccW+E-Yps.-oSYW-ctVcshVHcIQDNNEsp..SNEEKAslI+-sL-KIMTNDtFYVlVaD.hsh....supcapasltts.c+paIuSaNRGsCNVhVaRS.....t+s+ohsppsc-L++KaQHsLss+app.....Nspahlpspu+shps+lss.CGaVtlVRsscclA...Vcsoss-.tp+GPGthh-usFctssh...hSs.csFpl	............................h.........th..ltpph..thtphc.hhst..ph.........................phh..h..lhphh.ssht..............s.p.sht....................Ftt.ht..p..Phph...............sh................h.thlp..p.oNPlhhsh.t....p....pttshppWpthhtthhsphhhlEshhtGh...tts..t.p.l.p..t..th.p.htphppta...........................................hW....pthcphlpp..h.pptt.h...sptp+AphlpptLpp.h..hoscs.F..alhVhs............t...h..................ppp.hl.s..h....p.s.t....hshhlYRS.................t.p..t....t.......t.h.tp..ht...................................................t......h......p.....t.hhhhh.t............hp.st..........tPG...............................hhh......................................................................................	0	20	31	141
+2316	PF05085	DUF685		Protein of unknown function (DUF685)	Moxon SJ	anon	Pfam-B_6261 (release 7.7)	Family	This family consists of several uncharacterised proteins from Borrelia burgdorferi (Lyme disease spirochete). There is some evidence to suggest that the proteins may be outer surface proteins.	25.00	25.00	28.80	28.80	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.87	0.70	-5.34	4	176	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	29	0	9	140	0	217.00	43	96.09	CHANGED	KLLIDEEETVQIKDLNKVTTVNNsDLLLLDDGVASSNAITFKNFL-ToKDKTFKGEGLuYFKEIIKSTIAEELAADc-FVEKIYsKIhDKLINNDSTNLSNLFSKIKSRLTDSISSATLSRSDcLLIM.SSuTIQKTPVPKQLLGlPSsashstphTcuTTlYPSDYcspuIhIsM-sauDVsLlF.KSsDDpPIYLDIDIclKHpcNc..sKuLhlpYuDETphshVYhhpGusuluhRIPhYKGWYlQKRsph.GcPVPhLlKL	......................................................................KLLIDEpETVQIKDLN+..VopVNsoDLLLLDDGsuSSsAITaKsFLcsspcchF.KGEtLsYFKpIIK.....STIApELsusp-FlcpIYsplhsKL.Ip....N....-.S....sp..lusLFpKI+SpLpsuIsp.s.TLo.cs-pLLhh..pssI.QKTslPcplhGlPssath.....t..hs..........sspla..p...Yc.........sKthhIsh......c..p....sssollh.Kp.Dsp.sIYLDI-lc..lch..p..p...st...pK.lhLpYsDEo...ppph.lYt.h.p.us..p.t....shphPhYpGWY.lQ++.t......Gt.hP.h.Kl....................	0	5	5	5
+2317	PF05092	PIF	DUF686;	Per os infectivity	Moxon SJ	anon	Pfam-B_6313 (release 7.7)	Family	This is a family of dsDNA Baculovirus proteins. It is required for the infectivity of the OBs or occlusion bodies. It is a structural protein of the ODV envelope required only in the first steps of per os larva infection, as viruses being produced in cells expressing the gene for this protein but not containing it in their genomes are able to produce successful infections. Baculoviruses are large DNA viruses that infect arthropods, mainly members of the order Lepidoptera. In their life cycle, they produce two kinds of particles, a budded, non-occluded virus (BV), which buds out of the infected cell and is responsible for the cell-to-cell transmission of the virus, and an occluded form, the occlusion body (OB), which is responsible for protecting the virus between encounters with larvae. A variable number of virions are included in the para-crystalline structure of the OB, mainly constituted by the virus-encoded polyhedrin protein; these virions are called occlusion body-derived virions or ODVs. 	25.00	25.00	37.30	35.50	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	522	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.15	0.70	-6.14	26	72	2012-10-02 15:38:38	2003-04-07 12:59:11	7	1	65	0	0	71	0	489.90	37	94.42	CHANGED	lLLlll.....lhllhphlsllphtpp..h..htslphFDNosVP........lIcPPs.EIlIEuNshpCH+pL.TPCoocuDCslCREGLAsCQhFcEpsllpls-.....ppphsIcPGESYCLALDccRARSCNPsTGsWlLscocs.GaoLLCoClpPGLVTQLNlY-DCslPVGCpPaGpIssINpsPl+CsC-sGYVuDh.ssTpTPaCRPpplRDVlh-ssFFPRsPCssGalpl-HPuLcshYRpphth..slCVhDPCSlDPIoGpRps..G+Lhhhh.sspch..hshCsC....shpcsLasVa....sssoM....lp......ps.......stplsNACI...pPFslphpplpph-hKhFWGRss.h.pSDsDlVhpVs...spl.cs+Y+thLa.hlpsH.Pphs..pss......hhllKFoluhs.....hhtpsth...tpslaphYhphstpp..sss.CF..hPGh.GcC........Isss.ssCIpR..tsh.V.osEshssshCahoRpsptl.................plWssss..hYspsphPlshhlssh...hh..hh.sspsh...pslhhlsutssssp.tph.......ssLtplLsTYPpYS	.......................................llLllllhllhpalsllpht.cp.h..h.slthFDNspVP........lIcPPs.EIlIE...uNshpCH.+pL.TPCs..THtDCsl..CRE.GLANCQhF-Epshlphp-....tppphhIp....s....GES....YCLALDRcRARSCNP.sTGsWlLs................cocs......GauLLCoChpPGLVTQLN.hY-DCsVPVGCtPaGpIssI....Np..s..PlRCsC-sG....YVuDasssTpTPaCRPpplRDVhhDssFFPR.....sPCssGalpl-HPuLsshYppphph..slCVlDPCSlDPIoGpRps..GpLhhh..ss.ct..hshCsC....shtssLasVa...ssssuM..........lpps......stplsNAClpPFssph.tlpph-YKhFWu+s..........-.h.huDsDlVhpls...spl...ptRYchhLashlt.sHPphs..t........hhlhKFSluas.....hh.t..........tslaphahthpttp..sts.CF..hPGh.GcC.........Ists.s.CIp+..t...V.suEshtsphChhoRcsptl.................phWssss..hYspsphPsshhlpsh...hh.....sspph...pslhhltstthh.t..tph........ssLtplLtTYspYS.................................................	0	0	0	0
+2318	PF05095	DUF687		Protein of unknown function (DUF687)	Moxon SJ	anon	Pfam-B_6321 (release 7.7)	Family	This family contains several uncharacterised Chlamydia proteins.	25.00	25.00	32.00	30.90	23.20	20.60	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.62	0.70	-6.14	11	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	28	0	17	48	0	453.50	30	80.94	CHANGED	csuphssss.ph..s.stslh-s..lChh.ssssppstshpVslsYlNGStpTptEA.tEuhalS-.LRGcPVRslYNsG....puhupuhhhspRsShotppPlCpAlLcsWcpFFS+stNssppallIFaGDGGsaVQpALc...pohausRIhllGIuPohYVpGpspsHaYRVsGDlsohLDppGaspup....VoTLPYSuGu-GlFhPulpsPoFpaALRht..pl.................ltp.sthsussspDpp......uusthulhlshupsssuFoRlpchLsps-osuphEhNshP.sphhDllLoulaslhRloslhQtahlhs.lshps-s.lshlhhsuYssssLphhhLhhTNppstRcpaRslRllApuhpshhhLsslh-h.....lNhhphhppss..shlpAlahsuoshosollhh-...IhchshssLRsRlQphshRhhssss.c.....pccls................RsscuuhttslshlssssuGlhhulhhGlhNthulplPcs.....lscs.ssss............NsTslas.s.h+ss.........puWpoGDshulupTlshllshllllhslhshVp.VRpNt+RR	...........s.................slhps..ls...sspsp.sts..VtVsYlNuS.pshhcu.tEshaLSp.ltGc.VhhlYNpG....phhutshh..tp...pt..pPlspAllcsWctFFup....sppFlhhaaGsuuhaVppAlp...ps.asspIhllGIsPohalp.p..s..psaaYRV.G..shhohLD.tGahtup....VspLPYSsuu.Glhh..shtsssap.Alhht..ph....................hschSs.tsssspst...........upp..ul.ls.spssssFsRl.phLs.spTs.phE.N..hP.pph.shlhpshhslhRloshhp.ahhhs.lsht.ss.l.hh.hh.ashsslp.hhLhhTs..phRcthRshRllhhshpsh..hsslh-h.....ls.hhhhtps....hhpslahhhphhshsllhh-...lhchth.sLRstl.thshRhhts.s.c......ppphp.....................pp.hsshhhhhphlpssshulhhshhhGhhs.hulplsp......hspsss...............sposhhs.................sa.sscshulupshphhhshlhhhh.lh.hlt.lptp............	0	3	3	17
+2319	PF05093	CIAPIN1	DUF689; 	Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis	Moxon SJ, Bateman A,	anon	Pfam-B_6320 (release 7.7), Wood V	Family	Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [1].  CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis [2]. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress [3].	21.70	21.70	25.50	22.90	21.60	18.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.47	0.72	-10.97	0.72	-3.92	25	368	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	289	0	251	368	1	85.80	45	31.98	CHANGED	sDhcps..hs.tt..Cs.s......tK++KACKsCTCGLAEtpEpEppsppspppp........................................................t.........phps.t..SSCGsChLGDAFRCuuCPYLG...LPAFK..PGEcVpL	...................................................................................................................t...t..Ctss.....tp+++A..CKsCTCGLAEp.ctcppttptttt...................................................................p..uuCGsChLGDAFRCuuCPYl.G...hPAFK..PGEclth............	0	93	143	211
+2320	PF05148	Methyltransf_8	DUF691; Methyltransf_hyp; 	Hypothetical methyltransferase	Moxon SJ	anon	Pfam-B_6432 (release 7.7)	Family	This family consists of several uncharacterised eukaryotic proteins which  are related to methyltransferases Pfam:PF01209.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.42	0.70	-4.71	4	358	2012-10-10 17:06:42	2003-04-07 12:59:11	10	15	292	2	259	3274	773	201.90	38	54.17	CHANGED	sLpt+hpcRLDGu+FRaLNEpLYospuscAhchFpEsPphFcLYHcGFp.QVcKWP.pPlDhIIccL+........p+.sshVlADlGCGEA+IA...thpc..pV+SFDLsulsc+VhsCDM.uplPh-DpSVDlAVaCLSLMGTNltsFl+EApRlLKsGGlLhlAEVpSRFs..SlchFt+tlsKLGF-hpphclpNshFhLF-FpKss..hhu.Kc.h.slpLpPClYK+R	...........................................................................................................................s.L.tphtt+LtuuRF.RalNEpLYTpsSpp.Ah.phFppsP.p............h.F.p......Y....Hp.Ga..pp...Q..V..p.....p....W.P.....N.P..V....D.h..h....lp...l+................................................................p.p...s..t...p...h...s..l..A.Dh..GC...G............-.......A....p....L.A....................ps.h......p........p...........p..............................V...............a.......S.......F........D..............L..............h..............u................s...............s.................s............h..............l.............s...............s...............s..............D..............h.......u...............p...............l..............P.....L.............t..........s.......pS.......lD....l.....s.....l....F.....C.....L...S......L.....M.......G.......T.....N....a....h.......s....F......l.c...EAh.R...lL.+..st..G...........L..h.....l........A........E.................l...p....S......R.Fs...................s.s.p...t.....F....h...p..h..l..p......h....G....F...h.............t...........p.hFhh...h.h...+.................................................................................................................................................................................	0	97	153	220
+2321	PF05114	DUF692		Protein of unknown function (DUF692)	Moxon SJ	anon	Pfam-B_6476 (release 7.7)	Family	This family consists of several uncharacterised bacterial proteins.	25.00	25.00	26.90	26.90	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.63	0.70	-5.49	7	833	2012-10-03 05:58:16	2003-04-07 12:59:11	8	2	668	1	283	808	137	271.00	36	91.05	CHANGED	hhpuAGLGhRpslhcshlsh.pssslpFlEssPENahshGGhhhtph-pltER.hPlshHGlSLSLGGtsslDhshLcslKthhcpacshhhSEHLuaspscG.pLa........DLLPlPaT--Alc+lstplR.sQDhLtp.lhlENsShYlp.s.pphsEl-FLpAlspcssCtLLLDVNNlaVNAsN+Gh.DPhtaLsslPscRlshlHlAGHspp..u......................spLhIDTHGtsVtssVWsLLttAhuRhus..PTLLERD.NhPPhuELhAEl-pItth.p+uttAtt	....................................................................................h...tsGlGhRtphhpthh.p.......................t...s.........sl.s....ahEltsEN..a......h......s...................G..G...h.......h..t.....ptL..cpl.t-..c..aPlshHG.l...u.L.Sl..Gu....s..s...PLD....tsa....L.p.pl+phhcphpsshhSEH..Lua...s...p....s.....s.....G...a.ha..................DL......LPl...Pa.Tc.Eul.cplsp.+lcpVQ-hL..t.c...lhlENsS.......t..Ylp......h.....s......t....u..phsEs.....-Flstlsccss..CtLLLDVNNlYVsuhN.H..........Gh.....D.........s.....t.........s....a....L....ssl....P.hc+Vs.lHlAGHs...pp......t........................ss....l.lID.THup..sV..ss..sV...WsLhpt...........sht..p.h............G.....s.....hP.TL.l..EhD.tslPs.hstL...hsEh...pphpph.t......tt..................................	0	73	162	234
+2322	PF05113	DUF693		Protein of unknown function (DUF693)	Moxon SJ	anon	Pfam-B_6473 (release 7.7)	Family	This family consists of several uncharacterised proteins from Borrelia  burgdorferi (Lyme disease spirochete).	25.00	25.00	29.80	25.00	18.00	17.60	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.08	0.70	-5.50	2	142	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	27	0	14	124	0	282.70	62	98.41	CHANGED	hlLLpYDFKIEFYcscpS..KcoosG.sh.EETPKIIINTQHGIHlDIoISN.aSNhphlpSKpsKIVLWNLPLDFsscIchGDIVKIaYKKFAHEKpFDFIMAGhLGTPMSTDYPGGDFSVELDVRLhspSNFFNRKL...EsKsFKGKTVQEAIESVFPNRNIIpMDccDRLKlI-KsIYATTPKEFlDKIKGlYlHsVIADlGss.hss-CNhIFTN.+phtus.pYcALEDYGLEFIPQQEIsltspaKIphlaWNApTFYTHKLplGDKVSFIDGLGKMIKTTIKETSApLSNsGECSLILKLcDDSscpc	...............MLLLQYDFKIEFYss..c..pS..Kco.sG.shsEEhPKIIINTQcGI.H.lDIoISNha.S.shNhlpSKpuKlVLWNLPLDFTccIchGDIVKIYYKKFAHEKs..FDFIMAGhLGsPMSTDYPGGDFSVELDVRLhopSNFFsRKL.........EsK...NFKGKTVQEAIESVFPNRNIlNMDEcD+LKII-KsIYAoTPKEFI-K.I.K.GhYlHsVIsDlG....s........s........shslECpaIFTNhtphtts..pYcALEDYGLEFIPQQEIsltsphK.h.phlaWNApsFaTHKL+lGDKVSFIDGLGKhIKsTIKETSARLSNsGECSLILKLhDDSs...........	0	7	7	7
+2323	PF05107	DUF694		Family of unknown function (DUF694) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of hypothetical bacterial proteins.	25.10	25.10	25.90	33.40	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.76	0.70	-5.17	68	568	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	510	0	201	554	13	266.70	31	92.36	CHANGED	lpNRh-FlhlaDVpsuNPNGDP.sG.NhPRh.D.ETGpGlVoDVsLKRKlRsalpt..........p.........................G....p......pIaVpcpshhp.............................................ppptphhsth...........................................ph......pt..t.t.............................tttscphtphhCppahDVRsFGAVhu..........................thssuplRGPVQhs.aApSlcPl..l.hphsIT+hssop.......t......-uc...cpus.....................................tpMG.cKahVP.YuLYthaGhlsspL.A..cc....TGFo--......DlcllhcALhshF-pDp.SuuR..GpMpsRtLlhacH........sst....lGshsuttl.................acp....lplsh..............pp.psscsap..Dh.pl	..........lpp+h-Flhla-VpsuNPNGDPssu.NhPRh.Ds-pGhGhloDVsLKRKlRshlp..t.........................G....h....pIa..lpppthhs.....................................................................pp..p.phhpth...............................................................phttt.h.t......................................ttptcchtphh..sp...p...ahDlRsFGAVhs.......................s.....thssupl+GPVQls.hupS..l.cPl..h..phsIT+ssssp...............p-sc..cpps............................................pMG.pKahVs.YulYthpGhlssph...A..cc..........TGFo--......DlphlhcALhphF.-pDp...SuAR..Gphps+tllhacH...........sst............LGshsuthl......................act.........lplph...................pt.p..p.ht-..............................................................	0	87	152	181
+2324	PF05117	DUF695		Family of unknown function (DUF695) 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of uncharacterised bacterial proteins.	22.40	22.40	22.40	22.70	22.30	22.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.53	0.71	-4.25	13	259	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	238	0	50	209	9	131.20	24	51.99	CHANGED	hppsWpsYhoplsD+.AhhohNlulhcphss..phhspllplplsappssEsGLPss-EatcLtch.s+l.splsAhs.slasG+lhssGptchaFYspps....sslh-sLsph.sashshshQ-DscWDhYFcFLh	..............................................................................ppWt.a.sh..l.s.sp.us.hplNlsh.hph.t.h..pphsphlplplt.apsssEsGhPot-EhppLtplE-plhp.pl....p.shs...slhsGplossGp.tcha.FYsccs....th.phltcsL.....p.p.h....c.h.th..p..h.thpcD.pW...chYhpaLh............................	0	16	33	43
+2325	PF05128	DUF697		Domain of unknown function (DUF697) 	TIGRFAMs, Finn RD, Bateman A	anon	TIGRFAMs (release 2.0);	Domain	Family of bacterial hypothetical proteins that is sometimes associated with GTPase domains.	20.20	20.20	20.30	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.61	0.71	-4.75	81	1824	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	1554	0	346	1241	405	156.70	29	46.24	CHANGED	hpspclhphhcphlhp.p-ppAcpllp+huhtsAsllAloPlsllDllhsshtNhpMlpcluclYGhchuhhuthcLh+plhtsluhhGssclussl....ltshLuh........slsuhluu+hsQGlssGhLTttlGhushchhRshs.......assts...lspllpclhpthcc	........................................stclht.htp.l.....hctpAcp.lp+hAttuuh....h...lA....lSPlsllDhshlshtshclIpcluplYGl-huh..h.u..t..h..c.......Lh.+.h.l..l..h.s.hA..h.sG.....u...s.c..l..sc..cl..........shshh.u......................slsu+l..o...spsuQGluAG...hl...Tt...tlG...h.tu.h....c.hhcshs............a.ttp...tltph.hpphht....p.............................................................................	1	76	196	287
+2326	PF01901	DUF70		Protein of unknown function  DUF70	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Archaebacterial proteins of unknown function. Members of this family may be transmembrane proteins. 	24.20	24.20	25.00	25.00	23.60	24.10	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.18	0.70	-5.39	16	72	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	43	0	46	76	4	303.90	22	86.25	CHANGED	.hhhllllhlalsluhl................phhhshllhhhuhhash....shlsuphlht.ht..........h.....................chphptpcphshhlllIGllhhhhsllhlGuIPLhcshlRtpLsshhhhhsaLhhlususllhu...phpchthhlhsh.............hLlsLhGYRTsVlsllluhhlhhYYsp+ls..t+tlllshlslhl.lLuluhhphhs.thts.s......lhhRhthThsVL-hIl...shsGshpGclphssl............GPRslIuphlh.shu..VoITsTlFGshhLDFGlhulhl.hhlLGlhhGlha+lspph.+ulYhhhYSlLluYsllGIETGhLDlslhlhYlhuhIlthh	............................................hhhhhlhhhalhh..h..................................hh.hhhlhhhhshhhhh......hhh.sphhht.h................................................hphhhppphhhhhhhlGll.hhh.lhhhtulPLhs.slRhtlss.....shlhhl.uhuhllhu............phpppthhlh.h..............hllsLhGY.Rosll..sllluhllhhYhp.p+lp......h+..llhhh....hhhhl.hlulshhthhh.t.tt..........lh.RhthTh.lhchll.......sh.uhhhGplhhss................sPRthI...........uphlh.hhs..hslTsTlhGshhhDFGhhGl.l.hhllGhhhthhhchtp.h..ptlYhhhhullhuhhhlulcoGhLsl.lhhhahhuhl...........................................	0	9	15	31
+2327	PF05142	DUF702		Domain of unknown function (DUF702) 	Finn RD, Sammut SJ	anon	manual	Family	Members of this family are found in various putative zinc finger proteins.	20.50	20.50	20.80	21.40	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.08	0.71	-4.05	16	166	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	27	0	104	156	0	135.60	46	49.80	CHANGED	utuGs.hsCQDCGNQAKKDCsHhRCRTCCKSRGFcCsTHVKSTWVPAA+RRER.Qpthuu.ttt.stt.........ssussc+.Rp.........sttoohssophssusss.thsspp....................aPsEVSSsAVFRCVRVoulDD.u-sE.aAYQTsVsIGGHlFKGILYDQGs-pp	...............s..sshsCQDCGN.QAKKDCsahRCRTCCKSRG....Fc....CsTHVKST.WVPAu+RRER.Qt.hsshttt...................ttsss++.+...............t.t.t...sshsp...sphsss...p.....t.h.th.t.p.............................hPtpVpu.AlF+CVRVoul--..u......-sE..hAYQssVpIuGHlFKGhLYDpGsc..t...........................................................................................	0	16	70	85
+2329	PF05152	DUF705		Protein of unknown function (DUF705)	Moxon SJ	anon	Pfam-B_6448 (release 7.7)	Family	This family contains several uncharacterised Baculovirus proteins. 	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.96	0.70	-5.44	27	75	2012-10-03 04:19:28	2003-04-07 12:59:11	7	1	73	0	1	97	1	256.70	34	92.37	CHANGED	hpWhsL+p+pu.hl+cHlLhlscasDLphl....uacplchhEaVlFthssp...........pphssppYthplhps.pDsMp-lRpplKpsaKsshLGHsaVlpc+.shYsh..LcEWhV...shh-V.p.ht.pshhachPH...VlVFDLDSTLIT-EcpVpIRDptVY-SLp-L+ptsCVLlLWSYGsREHVscSLpcscLs.sYFDlIlstGppssphsss............hhsDpphchhahspsFahD......hsstps.....LPKSPRVVLaYLpcpGlNahKoITLVDDLhsNsauYDhFVpVp+CP....PlsDWphYH-pIlcNIpcY-shap	.........................................................................................................................WhsLc.pts.hh+tHlLhlsphtDlhhl....thpthphhEallhths.p.............hs..pYhhphhps.tDsMp-hRhplKhsa+hshLGHhhllt.pc.shYsh..LpEWhl...sh.pl.p..ht.pphhaphPH...VlVFDLDsTLIT-E.p.pVpIRDstVY-SLp-L+ppGC...lLlLWSYGs+-HVscShccs..c..L..s....sa.FDllls..tGpphtp.ttt.............hhD..p..chhahppsFhhD..........hp.tpt........lPKSP+lVlhYLpchslNahKolTLVDDL.sNsasYD.aVplp+C.....PhpDWphaHp.Ilp.l.pY-t................................................................	0	1	1	1
+2330	PF05153	DUF706		Family of unknown function (DUF706) 	Finn RD	anon	Pfam-B_2804 (release 7.7)	Family	Family of uncharacterised eukaryotic function.  Some members have a described putative function, but a common theme is not evident.	20.60	20.60	20.70	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.86	0.70	-5.05	21	371	2012-10-01 20:28:14	2003-04-07 12:59:11	10	7	259	4	239	388	200	228.40	49	78.66	CHANGED	Yssu..p-RV+pFY+ppHp+QTVsashptRtcat..phs+tcMolWEAlEhLNsLVDESDPDs-lsQIpHhLQTAEAIR+D.sc...-WhpLTGLIHDLGKlLhh..F...u-sQWsVVGDTFPVGCpFs-phla.s-oFcsNPDhssPhYsT+hGlYp.sCGL-NVhMSWGHDEYhYpVhK.spSTLPccuLhMIRYHSFYPWH+cGAYpHLhN-cDcchLchV+tFN.YDLYSKScchsDlEpLKPYY.pLI-KYFPs...hlcW	.........................................................p-pVcphY+..HppQTlsashp.t+tpat........p.h.s..+.tcMolaEAh-..hLss..Ll..DE...SDPDs...-hspIpHhlQTAEuIR+D.sc...cWhpLsGLIH.....DLGKlLhh.........a.................up..........s..........QW....sVVGDTFPVGCta.sc.....plla...chF.........p.s.NPDhps..shY..sTchGlYp.sCGL-NVhhSWGHDEYhYpV...............hK..s.p.o.oLPppuLhhIRYHSFYPWHp....tG....s.YpcLhs-cDh.ch...LchVptFN..a...DLYSKs.s.p.h....s.....cl..-pL+.PYY.pLI-ca.hPt...hlpW.................................................	1	72	137	192
+2331	PF05212	DUF707		Protein of unknown function (DUF707)	Moxon SJ	anon	Pfam-B_6598 (release 7.7)	Family	This family consists of several uncharacterised proteins from Arabidopsis thaliana.	24.10	24.10	24.70	24.70	23.40	24.00	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.10	0.70	-5.30	9	266	2009-01-15 18:05:59	2003-04-07 12:59:11	7	11	48	0	153	263	5	249.30	42	72.25	CHANGED	hassopP+GAEhLPPGIVss-SDhaLRRLWGpPp..EDlspps+YLlshTVGasQKsNlsusV+KF.S-sFsIlLFHYDGRsotW.--hEWS+pAIHlSs+KQTKWWaAKRFLHPDIVA.Y-YIFlWDEDLGV-pFsAEEYl+llKKaGLEISQPGL-sspG..lsaphTtRRsct.EVH+....................shFVElMAPVFSR-AWRCVWHMI...............QNDLVHGWGLDFsLt+CV.......-sscEKIGVVDSQallHpulPSLGs...................QGpucputushpuVRsRsptEhphFpsRhusAEKph	........................................................................h.............LP.GIl..posh.h+..L.as.sp..............pph........t..p.LlshsVGhpQ....+t.lsthV....pKF...s...............p......sFslhLFHYDGpsstW.pph-WSpp...AI.Hlustp..QTKW.....WaA.KRFL..HP..DlVu.Y-YIFlWDEDLsV..-pFssc....c.....Ylcll+ccGLEISQPuL-sspu...lpaphT..hRp...t.......s........t..clH+....................tt.....t....th.s.t.t....sphPPCsu..........aVEh.MAPV.FSRsAW.+ClWH.hI...............Q.NDLlHGWGLDatLthCs......................tstpc+lGVVDupallHp.s.l..PoLGs..............................ps..ps.t.....p.s...hs.....h....tlRtpshhEhthFppRhtpA.t...........................................	0	28	91	123
+2332	PF05166	YcgL	DUF709; 	YcgL domain	Finn RD, Bateman A	anon	COG3100	Domain	This family of proteins formerly called DUF709 includes the E. coli gene ycgL. Homologues of YcgL are found in gammaproteobacteria. The structure of this protein shows a novel alpha/beta/alpha sandwich structure [1].	25.00	25.00	26.10	25.40	22.00	18.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.32	0.72	-3.85	61	977	2009-09-11 13:36:28	2003-04-07 12:59:11	8	2	970	1	147	486	68	71.60	58	75.14	CHANGED	CulYKSsKKsshYLYVt+..........+DsFscVPEsLhphFGpPphVMhlsLssc+pLApsDsccVhpslpppGFYLQhPPs	......CsIY+SsK+-pTYLYVcK...........+DDFS+VPEtLhcuFGp.PQhuMh.L.sL-GRK+LssADlEKVKpALsE..QGaYLQLPPP..........	0	27	60	108
+2333	PF01902	ATP_bind_4	DUF71; ATP_bind4;	ATP-binding region	Enright A, Ouzounis C, Bateman A, Yeats C	anon	Enright A	Family	This family of proteins probably binds ATP. This domain is about 200 amino acids long with a strongly conserved motif SGGKD at the N terminus.In some members of this family e.g. Swiss:Q12429, this domain is associated with Pfam:PF01042. 	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.19	0.70	-4.98	6	870	2012-10-02 18:00:56	2003-04-07 12:59:11	12	20	725	8	474	928	144	206.10	27	57.01	CHANGED	hKsAsLaSGGKDSshALYhAhcc.hEVcaLVslho-Nc-.SaMaHssNlclscl.AEulGIPllchhspG.cEcEV--LtshlcpLc...V-ullsGulhScYQKpRI-pVCRElGlKshsPLWc+sP.chh.EhlctGFcshllAVsAhGLscsWLGRclc+chlD-LpcLsE+YGIc.AGEGGEFETlVLDuPlF+tRlElcph-thWctphGahtIc+tcl	............................................................................hh..hSGGKDS...shs.h......hp..h.hpt.....sh.p...l...h.....h...L.........h.s..........h.......h........s............c.....t................c......Shhap.....shs.h.p..hlph.A....c.uh.s....l.....P..L............h...........t....h............t...........h..........p............s...............................p..............p..................c....................h..c...s..l....h.p...h....L....p....p...lp........................lc..u...l...shGsl.....h.s.....p.h.....p..+s.hh.-pl.................spc..l..G.Lpsh.hPLW...........p................c...............s......p...........p...p..........Llp...-h......l...........s..........t...............Ghcs.hl..lpVs.u..h..G.L......s.t.p.a......L..........G+......p..l...s..............p.....h.....h.t.p..L.hp..h........................s....l......c........ss........GEsGEacTh..VlDu..P..lF....c.p.p.l...ltt..p...h.....................................h......................................................	1	171	291	398
+2334	PF05164	ZapA	DUF710; 	Cell division protein ZapA	Finn RD, Mistry J	anon	COG3027	Family	ZapA is a cell division protein which interacts with FtsZ.  FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related proteins early in the bacterial cell cycle.  The interaction of FtsZ with ZapA drives its polymerisation and promotes FtsZ filament bundling thereby contributing to the spatio-temporal tuning of the Z-ring [1][2].	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.79	0.72	-4.02	162	2881	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	2807	8	629	1565	1385	96.40	23	86.52	CHANGED	plp....l.pIhG+pYplsssssp-ctLppsAphlcp+hp.clppp..ss.thssp+lhlh..uALsl.......uc-hh.......p....tcppt....tphpp....................................................................phppc......lcpLt............................ppl-	...........lslpIhGcsaplsh.s.s.-.........p...cct.L..ppsAchlsp+lp..-l+pp......st...shs...spc.l.....sll..sALNl.......spEhh...........p.......hcpct......pphtp..................................................................phppp.lp.ltt.....................................................................................................................................................................................................................................................................................................................................	0	210	399	517
+2335	PF05167	DUF711		Uncharacterised ACR (DUF711)	Bateman A	anon	COG2848	Family	The proteins in this family are functionally uncharacterised. The proteins are around 450 amino acids long. It is likely that this family represents a group of glycerol-3-phosphate dehydrogenases.	25.00	25.00	28.30	28.20	23.80	22.70	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.23	0.70	-5.76	53	1207	2012-10-01 23:28:04	2003-04-07 12:59:11	7	3	1155	2	247	890	31	418.00	60	95.97	CHANGED	M..p.ppIhETlpMlppcpLDIRTlThGIoLhDChssshp.htpplapKIs.phApsLVcsuccl....ppcaGIPIlNKRIoVTPIullut.uhtt.psh......lphAcsLDcAAcclGVsaIG.GaSALVpKGhopuDctLIpSlP-ALssTc+VCuSVNluoT+sGINMDAVpphGclIKchAphost..uhusAKLVVFsNusp.....DNPFMAGAFHGlGEs-sVINVGVSGPGVVcpAlcch..c.ut....s.............hptlu-.pIK+TAFKlTRhGpLVGppsuc+LsV...sFGlVDLSLAPTPshGDSVAcILEphGLppsGs.GTTAALALLNDAVKKGGhMAsopVGGLSGAFIPVSEDssMlcAlppGsLsl-KLEAMTuVCSVGLDMIAlP.GDTsscTIuulIADEsAIGhlNsKTTAVRlIPssG+csGD.V-FGGLLGpu.slh.lsphsuttFlp	.........................................................................hphpplhETlpMIccpphDlRTITMGISLLDClc....sDhpcssc+I.YpKIT.opApsLVtsG-cI....tsEh..GIPIVNKRlSVTPIulluu.As.ps...sDa...................VslA+sLD+AAK...clGVsFIG.GaSALVpKGh.ppuDchLIpS.IPcALupT.-hVC.S.S.VNlGST+.....uG.I.NMsA.VppMGcl...IKcsAchos.................hGsAKLVVFs..N.A.V.E.....DNPF.MAGAF........H....G....VGE..uDsl...INVGVSGPGVVKcALEcl.....+Gp...s................a-hlAE..Tl.K.K.T.AFKI.TR.hGQLVGp...AScRLGV......sFGIVDLSLAPT..PAlGD..SVAclLEEMG.L..E......plGoHGTTAALALLNDtVKKGGlMAsspVGGLSGAFIPVSEDpGMIs....AVpsGsLsLEKLEAMTulCSVGLDMIAIP.GDTsAc..........TIuuhIADEAAIGhINpKTTAVRlIPs.GpcsGDhlEFGGLLGhA.PlM.VsthSs.sFl.s.......................................	0	100	167	212
+2336	PF05168	HEPN	DUF712; 	HEPN domain	Bateman A	anon	COG2250	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.33	0.71	-4.21	92	1339	2012-10-01 22:14:54	2003-04-07 12:59:11	9	14	572	11	648	1274	106	115.30	18	27.05	CHANGED	hcthlcpAccsLcsAch.hc.ps..hYshusFtupQAsEhslKAlLhp..hstp..s+sHsltpLlp..hlpphh........spphhcth.......phLpphhhtuRYsshh...........scc-AccslptAcp....llch.h......cth	.......................................................hhppAppplptAc..h.....h....p...ps........ha.p......h..u.s..ap.sppu....sEpslKA...h...l...ht.............hsh....p........s........p.....s....H.s.l.t..t.Lhp......hlpph..................pph.tp.th..............phLpph..h..h...t...s..R..Ysshh......................spppsp.phlphspp....lhph.h...h....................................................................................................................................................................................................................................	0	263	417	547
+2337	PF05206	TRM13	DUF715; 	Methyltransferase TRM13	Wood V, Bateman A	anon	Pfam-B_10143 (release 7.7)	Family	This is a family of eukaryotic proteins which are responsible for 2'-O-methylation of tRNA at position 4 [1].  TRM13 shows no sequence similarity to other known methyltransferases.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.98	0.70	-5.14	29	265	2012-10-10 17:06:42	2003-04-07 12:59:11	9	15	192	0	183	340	36	237.10	27	56.06	CHANGED	hQQuSllGphcchph...L........ssss.....................salEFGAG+GcLSpalsp..sh.pp..............................stspalLlDRsspRh..KhDs+lppcp...................hlpRl+IDIcDLsLstl.p.................t...ptpth.......luluKHLCGsATD..LoL+Cllssshtpt....................................tsp..htGllIAhCCHHhCsacpass.........+ca.ltphGhs.pp.-Fphlp+hsSWAVsGpc.............................................t..tp..ttlshp-RcplGhhsKRlIDtGRlhalcpp.....Ga.pspLhhYsppslohENVsLluh	..........................................................................................QpuS.llt.hpp.thl........t.tp.........................salEFGAG+G.t...Lothls..sh.t....................................................................ttsphlL.l..-R.ts..Rh...K.hDtp....hp.ppt.............................................hpRlphDIpc..Ls.Lstl..........................................................................................t....tt..h..................lsluKHLCGsATD..hsL+Clhps.h.........................................................................................htulslAhCCH...HhC..pappass..........ppa..h..p..t.huhs.....tt.pFthhpphsS.WAssu.t.........................................................................................t....hs......tc+.......ptlGhhs+tllD.GRl.aLppp.............sh..pstLh.Ys..p..lo.ENhhlhs.h...............................................................................................	0	75	106	154
+2338	PF01904	DUF72		Protein of unknown function DUF72	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this family is unknown.	20.80	20.80	21.30	21.10	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.87	0.70	-4.61	218	2485	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	2050	4	731	1925	168	236.10	27	85.81	CHANGED	hYPpshsp.tp.pLp..hYupp..assVElNuoFYs.h.s.p........shtpW.tpp....sP..c.s.FpFslKss+hlT.H...t...ppLp...............................sspsh.ppF.....hp.slpsL...t..s+...LGslLhQhPP..s..hphsspphptlhphlsph...............................s........hphAlEhRHto.ah........s..th.hphLc.c....tslshlhsDsst......hs.hs.................hss............shsYlR..hHGpsth.................h.htYss......ptL...ptaupclt.t..htt...u......................cc.salaFsN.stp.s...pAstsAhpLtchl	.............................t..tp.pLptYupp..FssVElNsoa.......Yu.h.p..c.........sht+W..tp.p....oP....-..s...FcFshKhspslT..H.......p.ttlp...............................................pspct.l...ppF.....hp....tltPL...........t......s+..lG.llhQh...Ps.......s.......hths....s.cpl.stLh.phhpphs.....................................s.....h.shuVEhRH.s.aa......p..pph.hphLc.p....ps..ls.tll....sDptt.....sh.s..ht...............................................................ss........................shshlR..hpGpspht....................h..tYsp................ptl.....ptasp.+lt.p....htp....ts........................ppsalhhps.sstu....pAspsAtpLhp................................................................	1	225	443	602
+2339	PF01905	DevR	DUF73;	CRISPR-associated negative auto-regulator DevR/Csa2	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This group of families is one of several protein families that are always found associated with prokaryotic CRISPRs, themselves a family of clustered regularly interspaced short palindromic repeats, DNA repeats found in nearly half of all bacterial and archaeal genomes. These DNA repeat regions have a remarkably regular structure: unique sequences of constant size, called spacers, sit between each pair of repeats [2]. It has been shown that the CRISPRs are virus-derived sequences acquired by the host to enable them to resist viral infection. The Cas proteins from the host use the CRISPRs to mediate an antiviral response. After transcription of the CRISPR, a complex of Cas proteins termed Cascade cleaves a CRISPR RNA precursor in each repeat and retains the cleavage products containing the virus-derived sequence. Assisted by the helicase Cas3, these mature CRISPR RNAs then serve as small guide RNAs that enable Cascade to interfere with virus proliferation [3]. Cas5 contains an endonuclease motif, whose inactivation leads to loss of resistance, even in the presence of phage-derived spacers [4]. This family used to be known as DUF73. DevR appears to be negative auto-regulator within the system [2].	22.70	18.80	23.30	19.50	22.60	18.70	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.54	0.70	-5.55	28	278	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	233	4	129	276	8	245.00	21	77.26	CHANGED	lsuRhhlpscuLNtsEusG.NhscpR+ssll.hppt.......aplthVPslSGpultHtattsLsclutpp...shslschscph...thhhphsstp.h..............t..thEpphlppsslpDltGFLh...........s.tsps.............l+RsSslphoahlPs.cthp.......h-sthHsRas................ttppppQslaphEtuSulYshohslDlstIGhsps.................................................................p.phslpsc-+.pcRlcsulcALh.hLsth.hGA+psRhhPlht..phVsuloc.tPhss.s..sth.scYl-psh	................................................................................h..hph.hphpuhNh...s-.u.....h.....G.....Nhsph++l.................hpsp.hshlStpul+athhptlt.c.hh.t.......p........h....t...t........tthhpht.......................................................................................................ppsslpphhptDlaGaMp.......................................stpsts..................hpRsSsl+lo.hlulpsht..............h-hpF..tsphs......................................t......ttp..ss.slaphEhp.p.uhYphohslDLcplGh..s.pt.............................................................................t.htl..spc.E+..tcRlpthlculth.hst.s.htu.+.hspht..Phh....hlhsh.p.......................h........................................................................	1	58	86	103
+2340	PF01906	YbjQ_1	DUF74;	Putative heavy-metal-binding	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	From comparative structural analysis, this family is likely to be a heavy-metal binding domain. The domain oligomerises as a pentamer. The domain is about 100 amino acids long and is found in prokaryotes.	22.40	22.40	22.40	22.50	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.20	0.72	-3.61	171	2580	2012-10-01 20:55:33	2003-04-07 12:59:11	12	6	1979	20	541	1427	512	98.20	39	85.64	CHANGED	MlloTTssl.tG+cIhchhGlVtG..psltup...slh+DlhAul+sllG...GchpsYp.chLpcARcpAlpchtpcApplGAsAVlulch-hssl......sp..uhh..lhAhGTAVpl	.............................................................MhhoTTssl.tGppIhchhGl.VtGpslhut......Nlh+DhhAu..l+.sl.lG............Gc...suY...p.c.Lp......cARc.AhpchtppActhGAsAlVGlchDhpsl...........up.....uM.l.....Vss.GTAVp....................	0	198	364	467
+2342	PF01910	DUF77		Domain of unknown function DUF77	Enright A, Ouzounis C, Cerutti L	anon	Enright A	Domain	Domain of unknown function.  The crystal structure of two of these members shows that this domain has a ferredoxin like fold and is  likely to exists as at least homodimers.  Sulphate ions are  are located at the dimer interfaces, which are thought to confer additional stability.  Although the function of this domain remains to be identified, its structure suggests a role in  protein-protein interactions possibly regulated by the binding of small-molecule ligands [1].	24.90	24.90	25.10	24.90	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.81	0.72	-4.31	104	1948	2012-10-01 20:40:01	2003-04-07 12:59:11	12	3	1567	27	505	1121	132	91.30	29	87.80	CHANGED	sslsllPlG..s.....ssSlupaVApshcll....ccuG.lpaplssMuTsIEG-.hDclhpllccsa-tshptGusRVhoslKlDpRpD.pp.tsh...ccKlpsVc	.....................hslsll..Phu...st.......sssVsphV.scslcll....p.p..uG....lp.a............plsshtTsl........EG-.hc-lhcllppspEhshp.t.tssRVhoslKl..chR.sp...hsh....ppKlpph............................	0	171	325	444
+2343	PF01918	Alba	DUF78; 	Alba	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Alba is a novel chromosomal protein that coats archaeal DNA without compacting it.	21.40	21.40	21.60	21.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.03	0.72	-4.38	126	745	2012-10-03 06:24:24	2003-04-07 12:59:11	16	6	348	31	496	820	75	66.30	25	38.49	CHANGED	splhVss.tpshhshlptshphl....................................................pps...tcpVhlpuhG.pAIs+AlsluEhl+pch.......s.hp.lpplshss	.............................................plhlss.tp.ltsalthshphh.........................................................pps...tccVhlpAhG.pAIs+sVslAEllKc+h..........shhp.hpplp...h.........................	0	148	273	408
+2345	PF01923	Cob_adeno_trans	DUF80;	Cobalamin adenosyltransferase	Moxon SJ	anon	Enright A	Domain	Cobalamin adenosyltransferase This family contains the gene products of PduO and EutT which are both cobalamin adenosyltransferases. PduO is a protein with ATP:cob(I)alamin adenosyltransferase activity. The main role of this protein is the conversion of inactive cobalamins to AdoCbl for 1,2-propanediol degradation [1].The EutT enzyme appears to be an adenosyl transferase, converting CNB12 to AdoB12 [2].	21.30	21.30	21.30	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.92	0.71	-4.45	180	2946	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	2347	41	715	2068	1103	162.40	34	75.35	CHANGED	IYT+TGDpGpT...uLhsGp...RVsKsc.RlcuhGslDELNohlGlsh..sth..............................pplpph..LpplQpcLFclGu-LAs..s.....t............hcls.pp.plptL......EppIDphstp..lssLcpFlLPGG.......stsuAtLHlARTlsRRAERthVsL.....tppps......l.ssts....lpYLNRLSDhLFlhARhhs	.........................lYT+TGDpGpT...sL...h...sup...RVsKsc..Rlpu...hGslDEhNuhlGhsh.sth...............................tpphpth.......LtpIQppL.Fsl.u.u-Lus....st.................................htls..pp..plptL................................Eptl..D.chstp...hs..s...L..cp..FlLPGG........stsuAhLHlsRTls..........RRAERthspl.....................tppps.............l..pstl..............lpYlNRLSDhlFlhuRhh.................................................................................	1	266	472	598
+2346	PF01925	TauE	DUF81;	Sulfite exporter TauE/SafE	Enright A, Ouzounis C, Bateman A	anon	Enright A & Pfam-B_3578 (Release 7.5)	Family	This is a family of integral membrane proteins where the alignment appears to contain two duplicated modules of three transmembrane helices. The proteins are involved in the transport of anions across the cytoplasmic membrane [1] during taurine metabolism as an exporter of sulfoacetate [2]. This family used to be known as DUF81.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.43	0.70	-4.92	912	12351	2012-10-03 02:02:08	2003-04-07 12:59:11	14	23	3983	0	3751	10142	8371	231.90	19	89.56	CHANGED	h.h.h..s..uhh..sG.hlsulhGh..GGul...lhlP..hLh......h.h..........h......................ssth.Ah..usshh....shhh..sshs.u...shs..a....h+....p.t.................l....s....h.p.h...........h..h...h....h.h.h......s.ulh.Gu...hl.G........uhlht..hls......sp..h.............h....phhhuh....hl.lhhuhhh...hh...........ptt...............................................ttt...................hhhthhhhhhh............u.hh.hGhh.uGhhGsG........uGshhsshhh..hhh...s.hshpp..ssuos.......th.hh....hhh........slsu.hhs.....a.............hh...........hGhls.....h...hhh.....h...lhhu.....ul...l..Guhl....Gsp.l....spcl....s.s...t..h.....l+hh...hshll..l.hhu....lth	...................................................................................................................................................hh.hhhuhh...uG..hlsul..hGh...GG..Gh.....lhhP.hLhh..h.....h........................s.sth..Ah......uss..hh...........thhh...sshs.u......sht...a........h+...........p...t............................................................l.......s.........h...p...h.....................h....hh.h...h..h....s.shl.G.u.......hl..G...............uhlht.......hls........sp......h..............................................................l..phlhsl.....hl....lh.h.ulhh.........lh.....p.p.h.........................................................................................................................t..t..............hhhphhh.hh.hh....................s..hh.hGhh..sGh...h...Gs.G....sGshhsshhh........hhh......sh.shpp.....ssuss....th..hhhh.s......................slsu.hhs........a..............hh........................................tGt.ls...........h....hhh.........h.........hhhu.sh..l....Guhl....Gsp..l.......s.t..p.h.......s..s......p.h.....l+hh.hh.h.lhh.hhuh.................................................................................................................	0	1230	2477	3207
+2347	PF01927	Mut7-C	DUF82;	Mut7-C RNAse domain	Anantharaman V, Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	RNAse domain of the PIN fold [1] with an inserted Zinc Ribbon at the C terminus [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.07	0.71	-4.23	57	605	2012-10-03 20:43:45	2003-04-07 12:59:11	11	11	493	0	310	595	66	132.00	26	50.48	CHANGED	.RFllDshL.GpLA+aLRhhGaDTh....ass.ch......................sDpplhplAtpEpRIlLTRD+tLhcRtthptt....hh..........................................l.pspcsppQLtElhp+hslph.phpP.hoRChpCNu......Lptls+pplhtp...............lP.tshphhpp...FhpCssCt+lYWcGoHacchpphl	.................................................................+FlsDshL.G.p.L.A.+hLRhh.GaDsh.......ass..sh..........................sDtplh.ph.AtpE.pRll..L..T...R..Dc....t....L....hc...+pthhtt.......hh.............................................................................l...pstp..p.pQhhclhp.ch.tl.t..tht..hsRC..CNs........L.....h.t.t.t.t.h....t........................................................l..h.h.t..t......a..C..CtplaW.GsHhtph.t..h...........................................................................	0	106	212	273
+2348	PF01930	Cas_Cas4	DUF83;	Domain of unknown function DUF83	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This domain has no known function.  The domain contains three conserved cysteines at its C terminus.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.20	0.71	-4.32	57	1113	2012-10-11 20:44:43	2003-04-07 12:59:11	12	15	868	0	454	1522	488	163.70	22	56.47	CHANGED	sGshlpYYhlCcRclWLhs+.pIsh-pssp.tVph..G+hlHE......psYp+..pp...+-lpl..s....shplDhlc....ttphhl...........tElKKSp+h.......pcAs.chQLhaYLahLc.cpGlpsp.GhLpYPcp++ppc....VpLs-cpccclccslpcIcpllppp.pPP.spcpp.hC.+pCuYh-hCas	..................................................................................................................h..shlp.ahhC...Rphhlhth...t..t.h.t...p....p........pht.......G....phlHc.................................................p...p.....tt..............cpl.l..p...................tuhh.D.hlc.........tt.tphhs..........................lEhK......c....u..ctt..............t...p...s....t....chQLsh..shh......L....c...h...h....G..h...p..l.p............G...........h.l..h..Y........s.....p......p....+....+....p.h.p............V.t.h....s....p....p...h......c....p.p....l....h......p..h..l....p.......p.....l....c...p.l.h........p....p......t.......h.s........P............s....p....t.p......p.....hC...ppCuhh.chCh...................................................................	0	183	320	397
+2349	PF01931	NTPase_I-T	DUF84;	Protein of unknown function DUF84	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this prokaryotic protein family is unknown.	20.40	20.40	20.60	21.10	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.59	0.71	-4.52	20	1061	2012-10-01 20:37:09	2003-04-07 12:59:11	13	5	1021	15	237	655	51	158.90	48	84.25	CHANGED	uSTNPAKIpAVppAFspsFstt.shclpGVsVsSuVsDQPhus-ETppGAhNRs+pAhphhspA-ahVGlEAGI-....s...thsFuWhVl.stp....ppG.u+SAuh.LP.hllcclh.cGcELG-VMDElsGpcNl+pKtGAIGlLTsspLoRoulYcQALIhALlPFhssph	..............................AosNPAKIpAlhpA...Fpcl...........Fu...pt......sscIsuVuVp.S.GVs.-QPhGsEET+tGApNRV...t....NA+..c.............h...h..P.........p..........A.........D.....aaVulEAGI...-..........s.................shT.F.uW.sV.l-sss........pRG..EuR.SAoLsLPsslLpcl+..p.....G..ctLGsVMsc..hsGh..cpItp..KpGAIGlFTsG+LTRsSVYaQA.VILALsPFhNs..lh.................................	1	59	118	177
+2350	PF01934	DUF86		Protein of unknown function DUF86	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of members of this family is unknown.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.21	0.71	-4.46	147	1619	2012-10-01 22:14:54	2003-04-07 12:59:11	12	7	989	2	590	1431	169	105.20	20	82.04	CHANGED	lhcslpplpphh........................................shs.hcpFh.p....sthhppAlh+plpllsEushclspc............................lhspp..thsa+phsuhRNhllHtYhs.lDhphlaphlpp.cl.......................ssLpphlppl	.........................................................................h..h...........................................t.t..hppah..p......sth...h...h.Ah.p.lphlhEushc.lspt.......................................lh.sp.ps.t.s.h.pphhshRsh....l.sHcYh.s...lc.h...chlap.hlpp.pl.......................s.lpphht..h.....................................	0	206	423	515
+2351	PF01935	DUF87		Domain of unknown function DUF87	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this prokaryotic domain is unknown. It contains several conserved aspartates and histidines that could be metal ligands.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.62	0.70	-4.54	46	1158	2012-10-05 12:31:08	2003-04-07 12:59:11	12	19	801	0	504	4373	796	209.10	16	38.09	CHANGED	lp..lGpLh..ssss.............ls.ltlDl.schls+HhAIlupTGuGKSpssulllpcll.........phss..slllhD.HG.EYspht..........................tspsplhsst........................lpIshhplshp-ltplh.h....t.ssss.ppphlppshpphp..................pphtphshpchlpthhppht......................................................thpphptpshttlhpplpphhpphtth.........tshhptl.....cssplsIl..-lut.....lsptttph.lsuhlh+pl	.................................h..hGt........ttt...........h....sh..l.sl...pc.hl.......s.c....H.hu.l.h...GsTGoGKS.p.h.l.p...h..L..lc.phh..............................ttts......phll.lD.s..c.G....E..Yssht................................................................................................t..p..h..t...h..hp.t..................................................................................h.h.l....s....h...................h.......p................p......c.....h.............t....h...h..........................................................hh.....h.h....h............................................................................................................................................................................................................................................h..................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	154	317	410
+2352	PF01936	NYN	DUF88;	NYN domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	These domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins (Nedd4-BP1, YacP nucleases; NYN domains). The NYN domain shares a common protein fold with two other previously characterized groups of nucleases, namely the PIN (PilT N-terminal) and FLAP/5' --> 3' exonuclease superfamilies. These proteins share a common set of 4 acidic conserved residues that are predicted to constitute their active site. Based on the conservation of the acidic residues and structural elements Aravind and colleagues suggest that PIN and NYN domains are likely to bind only a single metal ion, unlike the FLAP/5' --> 3' exonuclease superfamily, which binds two metal ions.  Based on conserved gene neighborhoods Aravind and colleagues infer that the bacterial members are likely to be components of the processome/degradsome that process tRNAs or ribosomal RNAs.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.13	0.71	-3.91	149	2912	2012-10-03 20:43:45	2003-04-07 12:59:11	13	43	1840	1	1150	2564	397	149.80	21	49.81	CHANGED	+lAlalDspNhhhs.p..............h.chcplhpplpp...........tGp.....lhhtpsYss...............tttt..............ppht...shL......pphG..........h.sl.......phhshhp..............sK.sshDltlslDhhchs..sph...DshlLlSGD..uD...Fs.llpplc.ppG.hpl.lhu................t.tssps......Lhsuss.pal........lp	.................................................................................................................................................................lulhlDspNh.h..t.........................................h.s.h.ptlhpthtp..............................................hsp......lhhthhYss...................tttt.....................................pshh.....phL.............pphu........................................................h..tl.................ht.h.shht......................................tK.sssDh.tls..lD.hh..c.hhhp...pph................Dsh.lll..SuD.......uD.......Fs...ll.pplp..cp..G..hpV.hshu..h............t.hsspt......lhpsss.pah...t................................................................	0	388	740	969
+2353	PF01937	DUF89		Protein of unknown function DUF89	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has no known function.	25.00	25.00	26.10	26.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.29	0.70	-5.66	86	886	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	573	7	557	885	43	317.00	21	73.89	CHANGED	shtcphPsll.ppslsslch.........spss...............pptcpllpphtp..lhtchppspshssh..............................................htshlaRclhphhs..........phDsFpchKp.ps.ppuhphl.pltpp..hcphtsp......................hhpphlclulhGNhhDhulhs.........pp.......ttphppthcpsl...llsD.hsphhptL...................ppspplshlsDNuG.ElhhDhl.LhchLhc...huscVhhtsKshP.hlsDsThcDhp..................................................tttlpc....thscllhp...........u.ss...ssshshtch........ss-lhptlp..pu-LlIhKGphNYcpL.ps-tpht.p..................lhhLhssKs-slssh..sshscpl	..........................................................................................................pphsh.hh.pphhtt......................t....................t.hpthhtth.p...hh.p..h.t..p..t.....h........................................................t.shh..h.....cplhph.ht...........hDs.a.t.c.Kp.pp.......p.....t.uh.p..hh....pl.tpp.....hpphtpp.............................................hhphlchslhGNhh.Dhuhhs....................pp......................ttthtpthp.p.sh.................llsc..hsphhptL............................................tttppl....hlhDNuGhElhhDhl.l.......schLlp.......hu.......s.................cVhhts+shP.hlsDsT.hpD..ht......hh.t.....h.......................................................ttthpp.........t...t..s..p.lh.h.p.................................s..ss.....ssshshtph.....................................s.clh.pt.hp.....puc......LllhKGthNaRpLhssh........th..t......................................lhtLthhKsphlsth...t..............................................	0	199	329	463
+2354	PF01939	DUF91		Protein of unknown function DUF91	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this prokaryotic protein is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.24	0.70	-5.20	4	795	2012-10-11 20:44:43	2003-04-07 12:59:11	11	12	704	2	245	677	167	188.00	36	75.29	CHANGED	+ttlllllApCpV.YEGRA+ScLspG-RlllIKPDGoFhlHpD.+Kh-PVNWQPPsS..h.clptsph.lhSIRRKPcEcLcVpIpElatsosa.scDhc-LslsGsEu-MuchIhcpPpLIEEGF+PltREYtlspGhVDILGpDccGshVllELKRR+A-lpAVpQLKRYV-.h+c-hs.ttVRGlLVAPSlTpsAccLLc-EGLEF+cL-PP+ss....++shcstphchF	......................................................................h....hhlhupCpspY..G.Rh.pupLs..u.RllhhKsDsol.lHss.tuhcPlNW.sss.s..h.............t.......p......................t..................t......................................l.......h...h.t......t.......ss-.L.l.ht.h........cls......tssL.hs...G.lE..scLQcLLs-p....p.h.l.....u...p.G..hpll.c..R..E.......Y...........T.....s.....h.....G...s.....VDlLspD....t.s....G.s.h.Vs.lE..lK.R+...u....p.h......-uVc.QLsR...Y...l-..hL.sc........-...............h.......h...s.........Vp..GlhsA.pp.Ipsp.A.+h.L.h.p-+Glchlhl-..h...........................................................................	2	65	167	218
+2355	PF01940	DUF92		Integral membrane protein DUF92	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family have several predicted transmembrane helices.  The function of these prokaryotic proteins is unknown.	20.40	20.40	21.70	31.90	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.42	0.70	-5.20	79	583	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	495	0	375	586	324	246.10	29	79.32	CHANGED	ulhlsh.lLuhluh+tp..hLshuGhluAhllGshlhshsGhthahsllsFalhGShsT+hthppKpphul..s.ptcs.GpRshtpVhuNuhsuslhAlhhsh........................tstsh....hhhuahuuhAsstuDThASElG.thhspps.hLIT.Th.+.VssGTsGuVSl.GshAulhGuhlluhsuhhls....................hssth.....hhhl...sluGhlGohlDSllGAslQt..............................thshLsN-hVNhlsThhu...ullu	.......................s..hhsh..hls.h..h..u..h.p..p+..sLshuGhhsuhllGhh..hh.hhs...u....hthhhhLlsFFls.........uohhTKh..p..tph..K......pphsh..............s....pcs....GpRsh............hp......VhuNussusl.hulhhhh...........................................................hhssh..hhhu.hl.u....uhAsssuDTauS.ElG.hl..t.p.pP.hLIT...Th..+............hVs.sGTsGGVolhGhhAuh.hGuhhluhsshhhh.......................................hsh........hhhl......sluGhlGollDSlLGAslQt.....................................................................................................ths.hLsNpsVNhlsshhsuh....................................................................................	0	120	231	311
+2356	PF01941	AdoMet_Synthase	DUF93; 	S-adenosylmethionine synthetase (AdoMet synthetase)	Enright A, Ouzounis C, Bateman A, Moxon SJ	anon	Enright A	Family	This family consists of several archaebacterial S-adenosylmethionine synthetase C(AdoMet synthetase or MAT) (EC 2.5.1.6). S-Adenosylmethionine (AdoMet) occupies a central role in the metabolism of all cells. The biological roles of AdoMet include acting as the primary methyl group donor, as a precursor to the polyamines, and as a progenitor of a 5'-deoxyadenosyl radical. S-Adenosylmethionine synthetase catalyses the only known route of AdoMet biosynthesis. The synthetic process occurs in a unique reaction in which the complete triphosphate chain is displaced from ATP and a sulfonium ion formed. MATs from various organisms contain ~400-amino acid polypeptide chains [1]. 	19.40	19.40	19.50	37.60	19.30	18.50	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.30	0.70	-5.97	48	243	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	220	0	139	229	20	380.20	42	98.33	CHANGED	hRN...IsV-phpptsl-cpplElVERKGlGHPDoIsDuluEulSRuLs+tYl-+a.GslLHHNsDcs.lVuGputPcFGGGcVlcPIaIlluGRATpch......ts.p......lPlssIAlcAA+caL+cslthLDs-pc.lll-s+lGpGSsDLp-VFpcspt...lPhANDTSFGVGaAPLSpsEplVhpsE+hLNSp.hKpchPtlGEDlKVMGlRcsccIsLTlAsAhVDRalsshccYhphKppl+ctlt-hApph.....s..pccV.....cVtlNTAD...sh-csulYLTVTGTSAEtGDDGuVGRGNRsNGLITP.RPMShEAsuGKNPVNHVGKIYNlLuspIApclsccV-G.lcEVhVcLLSQIG+PIDpPhlAsspllsccG..hshsclcpclppIl-ctLsslsplocpllcGcl	.......................tNIhVp.hptpslpcpplElVERKGlGHPDoIsDulAEtlStsLuphYlc+a.GsILHHNhDcs.lVuGputPcFG.GGcll.cPIhIllsGRATpch......tspp....lPltplslcAA+caL+cslp.LDs-pc.l.ll-s+.........l..u.p........G.......S.........s..........DLh-lFpcttp..........lPhANDTShGVGaAPLopsEclVhpsE+h...LNop.t...h.Kp.....chPtlGEDlKVMGlRpscclsLTlAhAhls+alsshpcYhphK-plpptlpchupch...........s..tppl...........pltlNTuD....t.cpsslYLTVTGTSAEtGDDGpVGRGNRsNGLITPhRPMShEAsAGKNPVsHVGKIYNlLuppIAcclhcpl.cs.l.c-shVhlLSQIG+PIscPplsslpllscpu......h.t...phppclptIscc.LsslsplschllpGc.h..........................	0	34	81	112
+2357	PF01944	DUF95		Integral membrane protein DUF95	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family have several predicted transmembrane regions.  The function of this family is unknown.	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.33	0.71	-4.63	172	1288	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	1099	0	417	1025	82	170.70	20	68.88	CHANGED	lshllalhuhlhGh..hhsh......t.sphhpth..lst.h.thh.........................................h...hhtlhhNNh.tlshhshhhG...............lhh...Glsslhll.hhNGhhlGhshu..hhhppsh..........hh.hhthl....lPHGllElsulhluuus..Gltlu.................ht.....lltsth.................h........pphpsht...ptht...ptstlh..l.sshhllhlAuhlE.u..alosh	........................................h..hhhhhhuhlhGhhhs..........t.sph.pt.....hst..htphhtt.....................................t.t....h....hhtlhhNNh.h....lshhhhhhG.....................hhh.G.ls.sl..hhL..hhsGhhlGhhhu...hhhppst...................hhhhhhhl......lPHGllElsulhluuuh...uhp.lu.......................ht.......llpsth.........................h...............tct.p.slt.......pthh.......phhthh....l.hhhsllhlAuhlE.ualos.h.......................	0	141	283	372
+2358	PF01947	DUF98		Protein of unknown function (DUF98)	Kerrison ND	anon	DOMO:DM04314;	Family	This is a family of uncharacterised proteins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.94	0.71	-4.46	20	217	2012-10-01 19:33:20	2003-04-07 12:59:11	11	6	206	6	95	274	193	150.60	30	71.93	CHANGED	LLGDGSPTRHLpLL.TucpspV-lIsMts.s..sss..........spuPpcVppL.......ssPllRRQVWLps......uupsLAaApSWWNtpcs-caLps....+stPIWpsLspt+sELaRElcGltLspuc.hLEptFs.pcGPFWuRHYpFa+cG+sLTlIhEVFSP.tLEpaL	........................................lhuDGShT+hLpll..ss.c.pltVcllp.phhs..ss....................sth.t.hpth..............ss.llpRpVhL+s........................usphlsaAp..S.h..h.sh...s....cl....s....p.t....Lpp..........pshPIGchltpp.....+hE.....haR...El.t..p...lh.h...s.c.ss.....h...L.....t..pt....ap....p....c..t......h....h.u...RcYpl..h..ps.spPlh.lIpEhFs..............................................................	0	26	65	87
+2359	PF01949	DUF99		Protein of unknown function DUF99	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The function of this archaebacterial protein family is unknown.	22.80	22.80	22.80	22.80	21.50	22.70	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.20	0.71	-5.19	29	165	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	161	2	106	166	10	177.70	29	89.74	CHANGED	KptlRllGlDDuhhtp.....cccshlsGlVh+ss.hl-GlhhsplslDGhDuT-sllshlps.phhtplpllhLsGlshuGFNllDlpclaccTtlPVIsVhc+tP-httlcpAL++hFscsp.c.Rhchlcph.Gphptl..............s.lahpshGls.ppAtcllpthohpu+lPEPLRlAHllApulhptp.+	.........th+llGlDDuhhtp................ptcshlsGslh+usthl.-Gl.shsplplDGhDAT-slhphlps...hth.plphlhLsGlshuGFNllDlppltccsshPVlsVhpctPchttlcpAL++.tFs.ssp....c..Rhphlcph.sphctl..............tslalpshGlshppAppllcthphpu.plPEPLRlA+llAsulh.....t...............	0	27	61	87
+2360	PF01207	Dus	UPF0034;	Dihydrouridine synthase (Dus)	Finn RD, Bateman A, Kerrison ND	anon	Prosite	Family	Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA.  Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae.  Most dihydrouridines are found in the D loop of t-RNAs.  The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap.  Dus 1 (Swiss:Q9HGN6) from Saccharomyces cerevisiae acts on pre-tRNA-Phe, while Dus 2 (Swiss:P53720) acts on pre-tRNA-Tyr and pre-tRNA-Leu.  Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD [1].  Some family members may be targeted to the mitochondria and even have a role in mitochondria [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.04	0.70	-5.59	17	9141	2012-10-03 05:58:16	2003-04-07 12:59:11	12	33	4628	7	2600	10106	4606	294.60	27	86.25	CHANGED	hlA.PMsGloDhhaRpLspchuss..........................LshoEMVsupshlpspphshthhsp.cps........hslQLsGs-PthhAcsAchst-.hGuptIDlNhGCPsc+VppstuGusLhpps-lltphlpshhcAVs...lPVTlKhRlGhD..-spppshchuctspssG.sphlslHGR.......T+tptaps..tAcaptItpl+psls...lPVluNG-Itsh...pcupptLptoGsDuVMlGRuAhspPhlht....tltpstht.pss.ht-h....hphhpp+hptlhphhu.tpulppht+HhtWhhpt...hssstth+pthspstshtch...httl....shhpsht	........................................................................................................lA.PMtshoDhsaR..........h.l.h....p....p....h.....us.s..................................................................l..h..h..o.E......M......l.........s....s.....p.........s.h....l.....h.....s.........s.....c....p......s......h......t....h.....h...sh.t..ppt...........................................t...lsl.Qlh..........G..s.-..P.pt.hu....c.s....A.c...h.......stp.....h.......G................s.....s............h................I.......D............l........N.h..G..........C.......Ps..p+..V........s.....p....p.....t.............tGu.....s.....Lh...p...c...P....c..l...l...t...pllp.uh..h.p.s.ls.........................lP..V.T.l........K....h....R......l......G..h-...................p.p..t.......p.....h........h...........-....hs...........p.t.........s................p.............p............s............G....s........s...........t..l.........s...........l.......H.u....R........................T.+.p.p..h..ap.......s...........p...s.......c...a......-......t.......I.......t....p............l................+....p...........p.......l...............s..................l....Pl..l.uNG...-...Ihsh...................pc...A...p..p...h......l.....p........t....s........G..........s.......D.........u........V.Ml..GR....u...Ah..s..p.Pa...lh..p..............h....h...p..p....t..........h...h.........s....t...s....tch.............................hp.hl....h....t....p....h....p..h..h......p........h..h..........s......................p........t......t...........t...h..t.....t.....h....p..+..p..h......h..h..h.pt..........h.s...s...t...t...h...+p.ht.t...tphtt...................thh..............................................................................................................	0	870	1575	2170
+2361	PF00692	dUTPase		dUTPase	Bateman A	anon	Pfam-B_127 (release 2.1)	Domain	dUTPase hydrolyses dUTP to dUMP and pyrophosphate.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.46	0.71	-4.68	29	7405	2012-10-03 01:18:03	2003-04-07 12:59:11	14	34	4788	263	1771	5446	3768	123.20	28	66.70	CHANGED	ppssh.sctpstsAGaDLhuspshsl.s..tssthlsTslthslPt.sphuhIhsRSul.utKGlllhs...GlIDpcapG.plplhlhNhspp.shplppGpRIAQLllh.hhp.....hp.spsh.cpopRGstGFGSos	.......................................t............suuhDl..h...s.......s................s.......h.......h......ltP.....s........phs....LlsTs.l..t..l..p..........l...........P.........c...sh....h........u.........h...........l....h.sR.Sul...u.p.p...t...h..l...l...h...s...Gh.I.DssY......c.....G...p...l..t..lt..l......h.N......h......u..........p...t...sh.......p...........lp......sG-RIAQh.lhh.h.p.............sth.p...h....p...ph.....s......t.....p...+GptGhs..........................................	0	563	1093	1455
+2362	PF02670	DXP_reductoisom		1-deoxy-D-xylulose 5-phosphate reductoisomerase	Bashton M, Bateman A	anon	COG0743	Family	This is a family of 1-deoxy-D-xylulose 5-phosphate reductoisomerases.  This enzyme catalyses the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH [1]. This reaction is part of the terpenoid biosynthesis pathway.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.66	0.71	-3.60	87	3428	2012-10-10 17:06:42	2003-04-07 12:59:11	11	6	3275	79	838	2723	1839	125.40	42	32.41	CHANGED	lslLGSTGSIGspTL-V..lp...pp....P-.pFplsuLsA.spNlchlhpQs..pp..F..pPph..l.sls-ppt....hppLpptl........t.......tsplhhGpcult...clAsh....scsDhVlsAIVGsAGLhPTlAAlcuG.KpluLANKEoLVsuG	..................................................lsILGSTGSIGspTL-Vlp...pp...........P-....pFcVsALsA.GpNls.hlscQs..tcF..pPch..s..sls..-..p.ss......spp.L.c..ptL.............s..........................tsclh.sGppuls....-lA.sh..........s-sDhVhsAIVGu.AGLhPTLAAlc.AG.KplsLANKEo.LVsuG.........................................	0	295	570	722
+2363	PF00350	Dynamin_N	dynamin; 	Dynamin family	Finn RD	anon	Prosite	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.96	0.71	-4.43	79	6429	2012-10-05 12:31:08	2003-04-07 12:59:11	18	111	1940	32	2723	11019	2690	176.80	21	26.13	CHANGED	lsVlGs.SuGKSSlLpuLlGpch..LP..puss...sTcpslh.lph.........................................scp.p.............sphp..ht-h.....tpphpshsplppthpppppphs.....th..................................................................slhhphhs.ts.sloLlDhPGlsp..ssstcp.................shsppal.ppsslILhl.s.sust...shups..-thplspplDspsp+.........o.lsVlsKs	.......................................................................................................................................................................lsllGs..SuGKSo...llp.u...l....l....G.........p.......c.....h.........LP....puss.............s..T.p...p.s.h.....h..lph..................................................................................................................................................spptp...........................................p..htp........................tpthps..h....p....p.......l...t....p.t..h..p..t..p..h.p...t...h..t....................................................................................................................................................................................................h....h....h..h.s....h..h............s...l..s..l..lD..h.P......G.ls...p...ssstpp...................................................phhtp...h...l...p..p......s.......s...h..l...l...hl..h..........s.ss.p.......s.hs.....ps.....-.......h.............h.h...h....p......h.c....t.t..h..............h.hhlhst....................................................................................................................................................................................................	0	828	1542	2205
+2364	PF04912	Dynamitin		Dynamitin 	Finn RD	anon	Pfam-B_5757 (release 7.6)	Family	Dynamitin is a subunit of the microtubule-dependent motor complex and in implicated in cell adhesion by binding to macrophage-enriched myristoylated alanine-rice C kinase substrate (MacMARCKS) [1].	25.20	25.20	25.20	25.30	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.28	0.70	-5.66	8	360	2009-11-18 13:30:50	2003-04-07 12:59:11	9	7	237	0	243	360	0	273.70	22	85.27	CHANGED	hIuhsQ.DlYETsDsPEs-ssph..pp-EssscsIEplplssscAapKFps+plsssslDFSDpIuK+p..+pGYphc.puEaEllGp..uppETPhQKhQRLQpEhtELh-Elpshpsssppsc.EEclSssAL.upslssLccpLcsL....+LppllGp.csl.sssp..t.s.sp+LloplEpa...........p.........pp.s.hutsssp............ptschspsu+lAsLE+RLtcLEsslGs.cs-h.s.Lssshp..sssll-u.....lpplpuKsuLLssspLDtlEpRLsslhtKhppIs.E++sus.pDssp-pKIs-LYElspKW-slspp....LPpllpRLpoLcuLHcpAspFuptlupL-ssQpslpspLssspsLLpcVpcs.....htpNLpslp-slsplEuRltsLp	..............................................................s...........................................................................................................................................................................................................................................................................................................................................................-.........s............p+htRl....Ehtph.t...ph.......t..t..........................................tt................t.............h....p.htt...hpp.L.t.......................t.p...........s.....................................tt.....tht....................................................................................................................................................p........t..........t......t....chsph-pRlt.lEthlt...t...................t...............tslh.s.................lp.lptp..lsh.L...p.........t........lpthptcht....l..tchp.......t......l.........t....p....tp..............t...............t......................................t..............t...............t................p..............p......p.............p..........K..............l.......p.t.lathh.phpshts................lP.llpRlhslptlHttAh.phs.......p.lptl-pppt.htpplpp.pphlptlppt............htpshthhtt.httlct+htt..t............................................................................................................	0	80	126	197
+2365	PF01221	Dynein_light		Dynein light chain type 1 	Finn RD, Bateman A	anon	Prosite	Domain	\N	24.90	24.90	25.00	25.10	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.12	0.72	-3.99	75	1105	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	322	46	723	974	9	86.60	39	73.19	CHANGED	h.....s..ptps.hlKssDMs--..Mpp-AlchutpAl..-....+as...h-..+-.lAtaIK+EFDc+YGsoWHCIVG+sFGSaVTHEsppFIYFhls.ph..ulLLFKou	.............................................................pshl+ssDMs--.....MQp-Al-.h....A......p..pAh.....-........+as..........h-.........+-..lA....taIK..+.-F.......D++Y.......s.......s.....o.......WH.C.I.V..G..+...s..FG...S.aVTH.....EsppF...l..Y.Fh.lu..pl.ulLLFKo.............................	0	331	455	616
+2366	PF00519	PPV_E1_C	E1; 	Papillomavirus helicase	Finn RD	anon	Pfam-B_48 (release 1.0)	Family	This protein is a DNA helicase that is required for initiation of viral DNA replication.  This protein forms a complex with the E2 protein Pfam:PF00508.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.55	0.70	-5.87	66	1112	2012-10-05 12:31:08	2003-04-07 12:59:11	12	7	265	44	9	1576	23	256.40	49	68.38	CHANGED	KFK-saGlSFs-LTR.FKSDKTsCpDWVlssa.GlpcslhEusKpLLppaCtYhalpp..stthGhhsLhLlpFKsuKsR-TVtKLlsslLsVs-pphLhEPPKlRSssuALaWYKpuhussshs..aGphP-WIs+QTllsHp..hpsspF-LSpMVQWAYDN-hs-ES-IAYpYApLA-pDuNAtAFLpSNsQAKaVKDCusMsRaYKRAEM+pMSMSpWIpcRspcl.-..ssGcW+sIVpFLRYQslpFIsFLsAhKpFL+G..hPKKNClllaGPPsTGKShFsMSLl+FLpGpVISasNS+SHFWLQPLsDAKluLLDDATpsCWsYhDsYLRNuLDGNslSlDtKH+uslQlKsPPLLITSNlsltp-c+apYL+SRlpsFpFss.FPhcssGsPlapLsDpsWKSFFpRhWspL-Ls-.pED-s.-..s....GssppsF+C	..............................................................................................................KFKEhYGlSFhELlRsFKSsKosCsDWslusF.Gl.ssolAEuhKsLlp.ashYhHlQsL.ss..shG.hllLhLlRaKCuKNR.TltKhlupLLslspppM.lI-PPKLRSsssALYWY+ouh..S..Nh..SpV..hG-TPEWIpRQTllpHu...h.p-.s.F-LSpMVQWAaDp...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	4	8	9
+2367	PF00122	E1-E2_ATPase		E1-E2 ATPase	Sonnhammer ELL, Bateman A	anon	Prosite	Family	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.33	0.70	-5.32	126	30268	2009-09-12 10:17:11	2003-04-07 12:59:11	15	261	5547	105	10217	25831	1942	229.00	24	26.96	CHANGED	hllhhlhlsshlphhpch+upcslppL...tphtsp.p.spVhcs...........................s...........phpp...............l.sspclssGDllhl.csG-plPuDuhll.........................................p...s..........shplDcShLTGEo.......hPlpKp..........................................psshl.....auGohlh...sG..ph......pshVstsGpsopluclsphl...ppspp.tc....................................sslpphls+lsphhshls.lslul.......................lsh...hhthh........................................................................t.shhpslhhu.lulllsusPpuLslssslslshuhtphu+pslll+.phsulEs	..........................................................................................................................lhhhlhls.t.h.l....p.h.h.t.....c...t..+.u.p...ps.l.p..t.L.........h..p...h.t..sp.....p.............s.p..l....l....c..s..............................................................................................G.......................p.h.t.p...................................l...sspclh...s.......G.Dll......hl......c............s..............G...........-.............p........l...P..sDuhll..............................................................................................................p.......u.................pstl..DE...S..h..LT......G..ES..............hPVpKp...................................................................................................................................................tssh..l......h.u..G..o.h.sh............sG..........ph............................hh..h..V..st........s.G.....t.cT..h..l.....u...p.........l........h.ph.l......p..pspp...pc................................................................................................................ss.l..pp.hh.s....p...l.u.t.h..h..s.h..h..s....l....hlu.h.........................................l.sh...........hh..hhh..................................................................................................ttsh..h..t..sl...h.hu...l...sl....l....l...s...ss...P...puLs..ls....ssh.slhh............u....s...t.....ph.u.c.p.s.hl....l+phtulE...........................................................................................................................................................................................	0	3318	6138	8457
+2368	PF00676	E1_dh	E1_dehydrog; 	Dehydrogenase E1 component	Bateman A	anon	Pfam-B_117 (release 2.1)	Family	This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.82	0.70	-5.70	16	9023	2012-10-02 16:07:47	2003-04-07 12:59:11	15	32	3995	112	2879	10789	7579	299.30	26	49.43	CHANGED	tchhslpRht-ttthhapcpthhGFsthpsGQEAsslGhttAlspp.Dhlhss..YRspuhh.hh+Ghs..lpplhsphhG+t....pspGGuh+..hh..s+p...ahsusuhlusQ...slss..GlAhAtK..........hcpcppVshshaGDGA.osQGphaEuhNhAslachPl...IFlscNNpauhuT.ssc+uuussshhphutGhtIPGlpVDG.DhlAVhpAsKhAt-hsppGpGPhLlEhhTYRhsGHShS.DssooYRspcElpch+tpcDPIpth+ctllspGlso--Ehcshccclcpcl--AhcpAcsss.sssp	.....................................................................................................................h.....htt.h..p...h.t.h.h.h.t.......t.t..t..........p.h..u..h............t..st...su........p............p.....Ah..p..huh..t...t....u..h...p.....t......s.....D..h..l..h..st..........a..Rs+.s..ph..l.s...p.....s.hs................hppl.....h..s.p.h.h.Gct..........................................psp.u..s..s...h..p.............h......h............................s.......p.........t...................p........h.h..s...s..s.........s........lusp................P....lsh.............Gh..AhAt..p................................................h..p....s....p.......p.....s....l....s.....l...s.h.a.GDuA.su........QGsh.aE....sh.N....h...A.....s.l.....h............p.....h.....s.s.....................l.a.l.l..............N.N...p..h...uh..o.........T.....s......s...........p.........c....s.p.......u......s.p..........h.......h.s........c........h..A........t.u.......h........s....hP.s..h...c.......V......s..G..s...Ds.......A.Vh.....t....s.s....c.hAh-..h....t....p....p...........h..........c...........t....ss.lI-h.h.s.Y..Rh.tG..H..s...pu...D.....c..P...s....t...h............p.....sp...........h.p.p.h...p.p.c.......s....Pl.th.apch..L.h.....p.........p...G.........l.........h..o.p...-...c..h...p...ph...t...p...p...h...c...p...t...lp.ps.hp.spt.......t...............................................................................	0	974	1810	2435
+2369	PF00524	PPV_E1_N	E1_N; 	E1 Protein, N terminal domain	Finn RD	anon	Pfam-B_98 (release 1.0)	Family	\N	22.50	22.50	23.20	25.40	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-11.07	0.71	-3.92	76	514	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	242	0	0	513	1	123.50	39	22.24	CHANGED	MA.....s.scGTc........ttssss.GWhhl..EA..ssc......spD-..Esh..h-p.....soDlsDhI.Dsssh.....pQssuhtLap.pQpspcsppplpsLKRKYht.....SPtss.........ppLSPRLpuls..lssp.pppuKRRLF.p.....DSGhup...ots-	...........Ms-.spGTss......tttGssGWFhV..EA..spc...s..o-D...-.tEp...t-s.....spDhs-FI.Dsss......pptsuptLap.tQpsppct..pslp.sLKRKahs.....SP.ss........sppplSPRLpuIs..ls...pp....pppuKRRL.Fp.p....DSGYGsops.......................................	0	0	0	0
+2370	PF00511	PPV_E2_C	E2_C; 	E2 (early) protein, C terminal	Finn RD	anon	Pfam-B_87 (release 1.0)	Domain	\N	25.00	25.00	25.30	25.30	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.69	0.72	-4.02	99	565	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	249	38	0	497	0	76.60	44	22.58	CHANGED	PllhL+G-sNsLKChRYRlpp+apsL.FpphSoTWpWss....ssssp.psuhlhlsasoppQRppFLssV+lPpulphthGhhs	...Pllpl+G-uNsLKChRYRl.p.+appL.apthSSTW+Wsu.........sss.pp.puhlTlTasScpQRppFLssVKI.P.solphshGhMo.............	0	0	0	0
+2371	PF00508	PPV_E2_N	E2_N; 	E2 (early) protein, N terminal	Finn RD	anon	Pfam-B_76 (release 1.0)	Family	\N	19.10	19.10	20.60	43.80	18.20	18.10	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.35	0.71	-5.14	82	467	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	250	13	0	494	0	197.90	44	51.73	CHANGED	MEsLspRLsusQEp...lLslYEpsSpsLp-QIpaWphlRpEpsLhatARcpGlp+lGaQsVPsLsVScsKA+pAIchpLtLpoLppStYupEsWTLp-TShEha.hssPppCFKKtGpsVEVhaD.s-ppNsMpYThWshIYhpssss..WpKspGpVDapGlYY.ptpstK.pYYVpFpc-Ap+YGpoG......pWEV+..hsspslhsP.sosoS	....MEsLspRLsAsQ-c...lLslYEpDSscLpspIpaWphlRhEsslhYtARctGlp+lsa.QsVPsLsVScsKAppAIEhQltLcoLppSpYusEtWTLp-TShEha.hosPppCFKKpGhoV-VhaD.s-psNsMpYTsWstIYhpsps............s...............Wp+VpGpVDapGlYY..hppGh.+..sYYlpFp.c.-Ap+Yupos......hWEV+..hssplIhsPsos..............	1	0	0	0
+2372	PF02319	E2F_TDP		E2F/DP family winged-helix DNA-binding domain	Mian N, Bateman A	anon	Pfam-B_8420 (release 5.2)	Domain	This family contains the transcription factor E2F and  its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a  homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows  that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.	21.20	21.20	21.30	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.61	0.72	-4.41	33	1416	2012-10-04 14:01:12	2003-04-07 12:59:11	15	13	169	2	833	1251	16	71.90	39	20.10	CHANGED	RpcpSLslLop+Fltlhpp....spc.shlsLscsAcpL....................ss..p+RRlYDIsNVLculslIpK.......hpKsplcWhG	................................................RhppSLthhopKF.ltlhpp..................sps....usl...sLs..p.....sAcpL...............................................ss..p+RRlYDIsNVLpulslIpK...........tpKsplpWhG............................	0	297	417	591
+2373	PF02817	E3_binding	e3_binding; 	e3 binding domain	Griffiths-Jones SR	anon	Homstrad	Family	This family represents a small domain of the E2 subunit of 2-oxo-acid dehydrogenases responsible for the binding of the E3 subunit.	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.38	0.72	-4.32	58	9252	2009-01-15 18:05:59	2003-04-07 12:59:11	12	41	3883	49	2483	6857	3964	38.30	38	8.78	CHANGED	scshAoPssR+LApEpulDLs...plp.GoGssGRIh+pDlps	...............hsoPssR+lApE.p.G...l...-....ls....pVp..G.oG.h.p.G.RIh+cDVp..............	0	779	1517	2071
+2375	PF00518	E6		Early Protein (E6)	Finn RD	anon	Pfam-B_57 (release 1.0)	Family	\N	20.70	20.70	20.70	21.80	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.34	0.72	-10.86	0.72	-3.72	26	915	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	239	6	1	645	5	108.30	48	74.15	CHANGED	ClaCpchLspsElhsFsh+-LplVaR-s.hsausCstCLphhuplcph+aaphSlausslEphstpslhclhIRChhCt+.Ls..EK.cpl.ppcpF+clp.spW+GpChpC	........................................CVaCKppLpp..pEVacFAapDLplV..YR.Du...PaAlCctCLchhSK..lpch.RaYp..hSlYGsT.LEphhpKsLs-lhIRChtCQ+PLsPpEKp+HlspppRFHpIp.G.....cWpGpChpC........	0	0	0	1
+2376	PF00527	E7		E7 protein, Early protein	Finn RD	anon	Pfam-B_95 (release 1.0)	Family	\N	21.50	21.50	22.10	22.10	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.56	0.72	-3.83	75	626	2009-09-14 14:24:34	2003-04-07 12:59:11	13	1	232	5	0	438	1	91.80	40	93.18	CHANGED	G.........p.psTLpDIVL..ch.pP.........pslD.LhCpEpLs....sop..-.........-Esc.t......................psYpllssC.sp..Cppsl+LsVpuopss.lRsLppLLh.ssLslVCPtCu	...................................................Gp.psTLp-hlL..-L..pP..........pssD.LaCaE.QLs....cSs.-E........-E...chst..t..............p.tpssYtIlThC..sp..CcsslRLsVpSTps-.lRsLQpLLh.GolslVCPtCu..........	1	0	0	0
+2377	PF00563	EAL	DUF2; 	EAL domain	SMART	anon	Alignment kindly provided by SMART	Domain	This domain is found in diverse bacterial signaling proteins.  It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function [1]. The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site [1].	21.60	21.60	21.80	21.80	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.59	0.70	-4.88	137	26968	2009-09-15 16:29:44	2003-04-07 12:59:11	15	1049	2504	33	6836	21773	1845	227.50	27	36.53	CHANGED	tpplppu...h..tpt..ph.thhaQ....P.lh...s.hpssp....lh...uhEslhRhpptptt.hl..sstp......ahshhcp........shhtpls.phllcpshp.phtph.........th.l..slNl....ss.tpltssp...hhptlt...thh.........th.ssp.lslElsEs..................pphp..phlp....p.L+p...hGhplulDcF..Gsshs.shph.ltplshc..hl.KlDpphl..tth.....stpspthlps........lhphucph........shpllAcGVEspp..phphltphGsc.....hhQ..Ghhh...upP	.............................................................................................................................................t...ltpA.....l....ppp.....ph.hlhaQ..........P..hl...............s..hpssp..................lh....GhEu...LlR...a..pp..s..p....t...s....hl.....sPsp.....................Fl..s.hAEp.................................t....Ghh.htls..phllc.pshp....p...ht.p.h.....................................shpl.....................ulNl.....................Ss...tp....l....tpss............hhp.plt.....phl.........pph.tlss..p.p....l...t..lElTEs.........h..............hps.tp..h.h.p.hlp............p..L+p....hGhpl.u..l......D..DF...........GoGaS....oL.......sh...L....pp...h...s..h..D.......hl.K..I..D+uFl...............pslt......pst.......p....s.....pt.......l.l.p.u.......................ll..p.l..u.c.pL........s.h....p.l.l.AEGVEopp...php.h..L.p.p.h..G..s.s........hhQGahau+P......................................	1	1860	4128	5580
+2378	PF04157	EAP30		EAP30/Vps36 family	Wood V, Finn RD, Bateman A	anon	Pfam-B_8830 (release 7.3);	Family	This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking.  EAP30 is a subunit of the ELL complex.  The ELL is an 80-kDa RNA polymerase II transcription factor.  ELL interacts with three other proteins to form the complex known as ELL complex.  The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity [1].	25.00	25.00	25.10	25.00	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.28	0.70	-5.19	67	648	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	296	8	450	643	7	216.70	26	60.19	CHANGED	sGluulpppptpppphs-hshphshp..clspLhpphpphhphhcphupptpschppssp...................phpphhsslGlss.....hsstc................h..uhspFa.ELuhplsEhsh........phhcpsG.......................G.....llsLp-lashhN+.....sR.tst......................................hlospDlhcAschh.cpLshs.hplhphs..............tuhhhlpsss.s-h.tspsplLphh............................................................................phtsslohtplspphs.......WohshupptLp..p.hhppGhlh..hD	...................................................sGluulpppt..pppp.sctsh..s.uhp..clspLh...........pphpphhshhcphApc..h..p..p.ch..p.p.s.sp.hcs.......................................pFpphstslGlss.........................sopc........................h...uhspaahELuhpl..sEhhh..............sshpc.sG......................................................G.........lls.Lp-lhshhs.+......uR...uhp......................................hlS......s..-DlhcAschL..csL.......shs..hplhphs.....................G.hhllp....shs............s-.........pstsplLphs...................................................................................................pht...uhlosppltppls...................WshthApphLp...t.h.ppGhlhhD............................................	0	156	251	373
+2379	PF01309	EAV_GS	EAV_env_prot; 	Equine arteritis virus small envelope glycoprotein 	Finn RD, Bateman A	anon	Pfam-B_656 (release 3.0)	Family	Equine arteritis virus small envelope glycoprotein (Gs) is a  class I transmembrane protein which adopts a number of different conformations. 	25.00	25.00	440.70	440.50	18.00	17.50	hmmbuild  --amino -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.41	0.71	-4.80	7	84	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	2	0	0	84	0	196.00	95	86.34	CHANGED	WWRAVHEVRVTDLFKDLQCDNLRAKDAFPSLGYALSIGQSRLSYMLQDWLLAAHRKEVMPSNVMPMPGLTPDCFDHLESSSYAPFINAYRQAILSQYPQELLLEAINCKLLAVVAPALYHNYHLANLTGPATWVVPTVGQLHFYASSSIFASSlEVLAAIILLFACIPLVTRVYISFTRLMSPSRRTSSGTLPpRK	WWRAVHEVRVTDLFKDLQCDNLRAKDAFPSLGYALSIGQSRLSYMLQDWLLAAHRKEVMPSNVMPMPGLTPDCFDHLESSSYAPFINAYRQAILSQYPQELLLEAINCKLLAVVAPALaHNYHLANLTGPAsWVVPTVGQLHFYASSSIFuSSVEVLAAIILLFACIPLVTRVYISFTRLMSPSRRTSSGhLPQRK	0	0	0	0
+2380	PF02905	EBV-NA1	EBNA1; 	Epstein Barr virus nuclear antigen-1, DNA-binding domain	Griffiths-Jones SR	anon	Structural domain	Domain	This domain has a ferredoxin-like fold.	25.00	25.00	53.10	53.10	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.54	0.71	-4.72	5	148	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	9	4	0	87	0	90.90	90	66.67	CHANGED	KGGWFG++RGQGGps.sKFEshA-uL+ALLuRCcuPRTosEGcWssGVFVYsGSKTSCYNLRRuLALCIPECRLTPLuRLPYGaAPGPGPQPGPLRESossYFLVFLQTplFAEClKDAI+DYIpT+PsPTssl+VTVCoFD.DuVML	.....KGGWFGKHRGpGGSN.QKFENIAEGLRhLLARCHVERTT--GsWVAGVFVYGGSKTSLYNLRRGIALAIPQCRLTPLSRLPFGMA................................................................	0	0	0	0
+2381	PF00378	ECH		Enoyl-CoA hydratase/isomerase family	Finn RD	anon	Prosite	Family	This family contains a diverse set of enzymes including: Enoyl-CoA hydratase (Swiss:Q13011). Napthoate synthase (Swiss:P27290). Carnitate racemase (Swiss:P31551). 3-hydoxybutyryl-CoA dehydratase (Swiss:P52046). Dodecanoyl-CoA delta-isomerase (Swiss:P42126).	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-5.25	13	26211	2012-10-02 13:07:06	2003-04-07 12:59:11	15	113	4081	502	8836	22457	13530	233.90	23	67.75	CHANGED	phphpsulAhlplcpPt.slNulssphlsElspulpphcsDssl+.ulllouscpsFsuGuDlp-hsst.....tp.sshptsstclapclpssshPllAAlNGhAhGGGhplALssDhtlAucsAp..hGhsEsplGlhPuuGGo.hLsRhlGhstAh-hlhsGcphsApEAh+hGlVspVVs............p-p.lhcpAlphspclssp............s.hulshhKphhpt.....hcpslspstptstptasushssccspcuhpu...................ahEc	............................................................................................................h....tssls.hls.l..sR...Pp...t.....hN....A.l...s......t...h.h.p...p..............l.........t...p...s...l.........p....p....h............p............p...........-.............s......s.......l.........c....s....l....l........l............s.......u............s.............s............c............s............F......s.............A.............G............u....D....l.......p.......t.......h.tph.........................t.....t.....h.........t..........t.........h.........h............p............t...............h................t............p................h.........h............p.........t...........l...........p.............p.............h.............s............+....P....l......l.Au...l...s..............Gh.AhG.G.G.h.p.Ls...h.s...s...D....h.t.l.................A............u.c..s..Ap..............h...u..h.s..c..s.......p..l..G....l.....h......P.......s....s.G.....u.s.........................h...L....s....+...h..l.............G......h..........t......t........A...h..........c.h............h...........h............s.....G......c...t..h............s..A.pc..A.h.p..h..........G...L.l....s..p.....l...ls......................................................................tsp....l........p....t....s.........h....p..h...u......p......p..l....t..tt.......................................................................s.s..h..u..h..t...h...h..K..t......h..h..pt..................t...........t...t............t.......t.......t.....................h.......t.....p...t....................................................................................................................................................................................	0	2394	5222	7277
+2382	PF04736	Eclosion		Eclosion hormone	Kerrison ND	anon	DOMO:DM04950;	Family	Eclosion hormone is an insect neuropeptide that triggers the performance of ecdysis behaviour, which causes shedding of the old cuticle at the end of a molt [1], [2].	25.00	25.00	48.60	47.90	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.34	0.72	-4.53	6	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	31	0	29	44	0	60.10	58	68.49	CHANGED	phDlhGGYDhluVCIsNCAQCK+MaGsFFEGpLCAEAClpFKGKhIPDCEDIuSIAPFLNKL	...........s.hsGhDhltVClpNCAQCK+MaGsaFpGphCA-uClKFKGKhIPDCEDluSIuPFLNtL...	0	8	11	26
+2383	PF02963	EcoRI		Restriction endonuclease EcoRI	Griffiths-Jones SR	anon	Structural domain	Domain	\N	19.90	19.90	20.30	20.70	18.60	19.40	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.51	0.70	-5.59	3	52	2012-10-11 20:44:43	2003-04-07 12:59:11	11	1	50	10	6	62	7	187.20	49	86.48	CHANGED	SpGVlGIFG-tAKtHDLoVGEVS+tVlsKLoEDYPQLoFRYRsSIcKKEINEAL+KlDPcLGQTLFVENASI+PDGGIlEVKDDaGNWRVVLVuEAKHQGKDIENIRsGlLVGKsKDQDLMAAGNAIERSHKNISEIANFMLuESHFPYVLFLEGSNFLTEoIcVTRPDGRVVsLEYNSGMLNRLDRLTAANYGMPINoNLCcNhFV+HKDKoIMLQAASIYTQGDGusWsuucMFEIML-ISKTSLRILGcDLFcQ	..........................................................................................................h+tplphp.h..N.hLptlcschs.pohFh.sspIKPDGGll..cl..KD..Dpt.h+l.lLloEAKhQGps..pIpt..h.GKtpp....tsGNAIERuaKNlsElANhMLpEt+FPYllFL-GoNFlTpsh.l.RPDGRhl.l.YssGhLNRlD+LTuANY.GMPINpNLC.N+Flphpst.IMLQAhSIYTpGpGttWs.p.Mh.hh.....................................	0	1	4	5
+2384	PF03974	Ecotin		Ecotin	Finn RD	anon	Pfam-B_54504 (release 7.2)	Family	Ecotin is a broad range serine protease inhibitor, which forms homodimers. The C-terminal region contains the dimerisation motif [2]. Interestingly, the binding sites show a fluidity of protein contacts binding sites show a fluidity of protein contacts derived from ecotin's  innate flexibility in fitting itself to proteases while [4,5].	22.20	22.20	24.00	24.20	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.76	0.71	-4.42	47	725	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	700	31	89	328	19	124.20	65	76.27	CHANGED	tcphts.aPtspsGhpRpVIp....LPt.ss...Es...sa+VELlsG+shpl...D.CNpptLu.Gplpp...........colcGW.GYsYYplsths...ss.......oThMACs...spt+pppFVsl..ust..hlpYNS+LPlV.VYlPcssElRYRlWp......up	..............L.EKIAPYPQAEKGMKRQVIp....LsPQcD...ES..........sLKVELLIGQTLcV...D.CN.hH...RLG.GcLEo...........K.T.LEGW.GYDYYVFDcVouPV.........STMMACP...DGKKEpKFVTAaLG-su.MLRYNSKLPIV.VYTPcNVDVKYRlWKA...............	0	13	29	57
+2385	PF00736	EF1_GNE	EF1BD; 	EF-1 guanine nucleotide exchange domain	Bateman A	anon	Pfam-B_488 (release 2.1)	Domain	This family is the guanine nucleotide exchange domain of EF-1 beta and EF-1 delta chains.	20.80	20.80	21.40	21.00	20.50	18.10	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-10.04	0.72	-4.29	87	874	2009-01-15 18:05:59	2003-04-07 12:59:11	14	17	487	11	461	872	67	86.40	48	37.56	CHANGED	hop....lllcVhP.s..sEsDhccLpcpl.cslptcul..s.s.ch.PluFGl+tLplhslltD.ccsusDpl.pEtl...sh.-t..........................VpSs-lsuhs+l	...................................KSs..llLDVK..PWD..DETDhpcLEcsV.Rul.p.h-..GLl......W.....G.uuKLVPVGaG.IKKLQItsVlED..DKV.usDtL.pEpI......pth--a..................................................VQSsDlsAhsKl.............................................................................................	1	149	255	374
+2386	PF00647	EF1G	EF1G_domain;	Elongation factor 1 gamma, conserved domain	Bateman A	anon	Prosite	Domain	\N	20.70	20.70	25.40	25.40	20.60	19.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.25	0.72	-4.34	40	588	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	372	1	292	576	1	100.60	47	27.49	CHANGED	Ksc.cPh-..sLPp...uoFs.lD-aKRpYSNpDT..hss..AlPaFW-p.aD.sEsYSlWhscYK..Ys-EL..ph.sFMosNLluGah.QRL..-.phRKauFushslaGcs.ssssIsGlalhR.....Gp-	.......................KsKcPh-tLP+.........uoFs.LD-aKRhYSNc-o...hsV..AlsaF.W...........-p....a..D...Es.a.SlWhs-Y+..Ys-EL..oh.sFMSsNL......lsGhF.QRL..-.thRKhuFushhlaGps......ss..ssIsGlalhRGp-................	0	96	162	239
+2387	PF00889	EF_TS		Elongation factor TS	Bateman A	anon	Pfam-B_1408 (release 3.0)	Family	\N	21.00	21.00	22.50	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.43	0.70	-5.02	168	5433	2009-09-12 05:55:42	2003-04-07 12:59:11	14	21	4607	24	1441	3651	3185	191.80	35	74.06	CHANGED	AuEGllsshl..psst........usllElNsETDFVA+s-pFpthspplsphsh.............t.....pt.sshc...........tlht..h.t.....tslpphhtthhuplGEphpl+R..h.thhps.....s.h.ssYlHst.............u+lGVllthpss.t.........plu+clAMHlAAhsP...phlstc-lss-hl-..+E+............................cl.............hptpstp.......................................p....GKP....................................................p...plh....-K.....llpG+lpKah.......pEhsLLcQsFV..p.DschTVpphlcptss.......pltpFsRaclGE	.................................................................AAEGllt..shhpssh..........usllElNsETDFVA+st.....tF.thspplsphhh........................................t...tp...ssh-......................th.h.t...............phppthhthh..u.p.IGEplplRR.........h.thhpt..............th......hssY..Ht.........................s+.l.GVls...h..pusst............................phu+plAMHlAAh..pP......phls...c.-..lst-h.l...c.+Ep.............................................pl..........................................hhppshp........................................................p..........GKP..........................................................cpIh-K.......hlpG+hpK.ah.......pEh.sLhsQ..s..al.......h.-...s..p...h.TVtphlcptss........plhtFhRaclGE.................................................................................................................................	0	539	975	1245
+2388	PF01132	EFP		Elongation factor P (EF-P) OB domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.90	20.90	20.90	21.10	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.58	0.72	-4.29	271	5656	2012-10-03 20:18:02	2003-04-07 12:59:11	15	10	4552	12	1140	2928	2197	55.20	32	29.59	CHANGED	c+chpYLYpDG-.t.ahFMDs-.oYEQhpls...tctlu.-shpaLpE..shplplhh..as.spsl	........+shpYLYp.D..G-..t.ahFMDsE.oYEQhpls...tctlt...-.phpaLhE..sh.p..splhh..as.Gpsl....................	1	382	741	957
+2390	PF04863	EGF_alliinase		Alliinase EGF-like domain	Mifsud W	anon	Pfam-B_4527 (release 7.6)	Domain	Allicin is a thiosulphinate that gives rise to dithiines, allyl sulphides and ajoenes, the three groups of active compounds in Allium species. Allicin is synthesised from sulfoxide cysteine derivatives by alliinase (EC:4.4.1.4), whose C-S lyase activity cleaves C(beta)-S(gamma) bonds. It is thought that this enzyme forms part of a primitive plant defence system. This family represents the  N-terminal EGF-like domain [1].	20.00	20.00	21.40	21.00	19.00	18.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.98	0.72	-3.98	6	87	2012-10-03 09:47:55	2003-04-07 12:59:11	8	4	21	7	34	96	0	55.30	63	12.67	CHANGED	hoWThKAAcEAEAVAAIsCSuHGRAaLDGlh.s-Gs.PhCECNsCYoGsDCSshlsNC	..........hoWoh+AAEEAEAVAsI.sCStHGRAFLD..Gll.s-Gs...PtCECNoCYsGPDCSp+lpsC.	0	6	24	30
+2391	PF01303	Egg_lysin		Egg lysin (Sperm-lysin)	Finn RD, Bateman A	anon	Pfam-B_1464 (release 3.0)	Domain	Egg lysin creates a hole in the envelope of the egg thereby allowing  the sperm to pass through the envelope and fuse with the egg.	21.00	21.00	21.10	21.10	20.60	20.60	hmmbuild  --amino -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.68	0.71	-4.11	24	77	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	40	11	2	85	0	88.00	52	83.19	CHANGED	ls+thEsAlKlpIlsuaD+cLspWlp+HGptl....oshQ+KTLaFVNR.RaMQTaWpsYhhahs++IttLG.RsssssDYsplGAcIG+..Rlshchh.Ysall++N...hlP+apsYMtclhup+suDlPl	.......ElAlKspIluGFD+pLspWLppHGptL....oslQ+KsLYFVNR.RYMQTah..a..h.......h........................................h..........h....................	0	0	0	2
+2393	PF00971	EIAV_GP90		EIAV coat protein, gp90	Finn RD, Bateman A	anon	Pfam-B_210 (release 3.0)	Family	Equine infectious anaemia (EIAV). EIAV belongs to the family Retroviridae. EIAV gp90 is hypervariable in the carboxyl-end region and more stable in the amino-end region.  This variability is a pathogenicity factor that allows the evasion of the host's immune response.	20.60	20.60	20.60	20.70	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.45	0.70	-6.00	3	1082	2009-09-11 14:56:58	2003-04-07 12:59:11	13	5	9	0	0	800	0	234.90	62	80.26	CHANGED	SKNSMAESKEARDQEMNLKEESKEEKRRNDWWKIGMFLLCLAGTTGGILWWYEGLPQQHYIGLVAIGGRLNGSGQSNAIECWGSFPGCRPFQNYFSYETNRSIHMNNNTATLLEAYHREITFIYKSSCTDSDHCQEYQCKKVN.......Nusph.sVsNTTEYWGFKWLECNQTENFKTILVPENEMVNINDoDTWIPKGCNETWARVKRCPIDILYGIHPIRLCVQPPFFLVQEKGIANTSRIGNCGPTIFLGVLEDNKGVVRGNYTACNVsRLEINRKDYTGIYQVPIFYTCNFTNITSCNNESIISVIMYETNQVQYLLCN.NNNSNNYNCVVQSFGVIGQAHLELPRPNKRIRNQSFNQYNCSINNKTELETWKLVKTSGITPLPIS	.........................................................................................................sF.sh.phtsNRsh.hsNpTuTLL-AYpREIT.IY+oSCsDSDHCQEYQCppVs..................s..s...................h.p..ss..p.s......o....s........E.....YWGFKWLECNQTENhKTILVPENEMVNINsssTWIPKGCNETWARVK+CPhDlLYGIp.IRhCVQPPFFLhp..pp.t..s.s.s.u.RIuNCGPTIFLGVLEDNKuslps...ssCplpphp.IpR.DYoGhYQlPIFYhCshTslpS.....................................................................................................................................................	0	0	0	0
+2394	PF01176	eIF-1a		Translation initiation factor 1A / IF-1	Finn RD, Bateman A, Mistry J, Wood V	anon	Prosite	Domain	This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.	23.00	23.00	23.00	23.20	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.04	0.72	-4.55	63	5916	2012-10-03 20:18:02	2003-04-07 12:59:11	14	9	5270	9	1627	2668	2074	65.40	52	77.15	CHANGED	cphph.GtVhchLuNuhacVphtsGpphLu+IsGK.h++plhIhtGDhVlVch.....psap..hsKucIsaR	..................IEhpGpVlEsLPN.uM..F+V.c...........L..........E....N..G..H.........h....l.L..AHIS.....GKhR....ppaI....R....ILs.G.D+V.pVEl........oPYD.....Lo+GRIsaR.......................	0	532	1008	1345
+2395	PF05091	eIF-3_zeta		Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)	Moxon SJ	anon	Pfam-B_6311 (release 7.7)	Family	This family is made up of eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta/eIF3 p66/eIF3d). Eukaryotic initiation factor 3 is a multi-subunit complex that is required for binding of mRNA to 40 S ribosomal subunits, stabilisation of ternary complex binding to 40 S subunits, and dissociation of 40 and 60 S subunits. These functions and the complex nature of eIF3 suggest multiple interactions with many components of the translational machinery [1]. The gene coding for the protein has been implicated in cancer in mammals [2].	17.50	17.50	18.80	17.50	17.20	17.20	hmmbuild  -o /dev/null HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.83	0.70	-5.88	36	378	2012-10-11 20:44:43	2003-04-07 12:59:11	7	10	262	0	257	371	7	443.00	41	90.26	CHANGED	hshhhssl..Nss.uWGPspssp.....th.........slPatPFSKuD+lG+luDW.......sshp............................pts.shu.ssp.ash................ts-DEsoFplVD.....ss+ss....tpt+sp.....thsptsttpc.....................tthhsppttputt+cttthtp..........hst+.stt.p................t...hR-uSVplps-WshlE..ElcFscLsKLs.l.ss.cs-Dl..sshGpl.aYD+saD+ls.sKs.E+.Lpph.c.Rs.hassTTo-DPlIpcLhpcspu.........................................................sVaATDsILusLMsssRSlYSWDIllp+hG.sKlFhDK..R-susl....DhlTVNEs.A..s-sPh-.......s....pssINospuLuhEAThINpNFspQVlhpspp..phpacpsp.PFhscspc....................uShuY+YR+asLssp................lpLlsRsElDulhp...s..sscspals..l+ALNEaDsKhps.....l-WRpK.L-oQRGAllAsEh+NNosKLA+WssQulLAGuD.hKLGaVS.......Rsss+DsppHsILuspsaKPc-hAsQhsLshsNuWGIlRsIlDhsh+..pp-G............KYlLlKDPsKsllRLYpl	...........................................................................s.......l..s.s.uWGPsthsp.......th.................shPYtPFSKuD..+LG+..huDWos...ts.p..........................pp.s.th.u..ss...p.ash................tt.-DEsoFplVD........ss+sp.t......hh...tpt..ph..............t.ttp.p.t.tpttt...................t...h..tt.tpt.ttptt..thtp..............ttp..hs.ttt...........................t+...RcuSVplps-WphhE..Eh-FspL.Khp..h.........ps......s.....-spDl.................tphG......t.L.aYD.+saD+ls..s......+s.E+....Lp..p.h.p...Rh.hasV..TTo-DPlIpc.L...tcspu.........................................................sVFATDsILuhLMsssRSlYSWDIVl.+hG.sKlFhD..K..RDsuph..........Dh.lTVsEs.u..t-sP.-................ptsshNsspsLuhEAThINpNFupQslhtstp...+hph.psN.PFhpts.-.............................AShuY+YR+acLsts................lpLlsRsEhDuVhp.................ss...sspspals..l+ALNEaDs+hps.........sl-WRpK.L-oQR....GAVlAoEhKNNuhKLA+WTspAlLAsu-....hKLG.aVS.......Rhps+s.stpHlILus.taKPp-FAsQhNLshsNuWGIlRsllDhshc..........t..-G................KYlllKDPNKshlRlYp.............................................	2	108	152	212
+2396	PF01287	eIF-5a		Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	eIF5A, previously thought to be an initiation factor, has been shown to be required for peptide chain elongation in yeast [1].	21.50	21.50	21.60	21.50	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.03	0.72	-4.03	97	832	2012-10-03 20:18:02	2003-04-07 12:59:11	15	11	539	15	474	760	38	66.70	37	40.40	CHANGED	hVcRp-aQ.LlsIpsDs.......alsLMs.-sG-T+-DlclP..........pt...plscclcsta....csG.c-h.VsllsA.MGcEp...lhshK	.......VpRp-YQ.LlsIp.pDG.......aloLhs..-sG-o+-D..l+lP..............-s......pLspp.....Icsta.......spG..c-...lh.VsVhsA.MGcEthhshK......................	0	143	254	374
+2397	PF01873	eIF-5_eIF-2B	eIF5_eIF2B; 	Domain found in IF2B/IF5	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the N terminus of eIF-5 Swiss:P55010, and the C terminus of eIF-2 beta Swiss:P20042. This region corresponds to the whole of the archaebacterial eIF-2 beta homologue. The region contains a putative zinc binding C4 finger.	21.60	21.60	21.80	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.74	0.71	-4.46	13	1012	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	491	15	654	962	101	123.90	36	40.09	CHANGED	huh.....pNsctsssDcp..RachPthpstlEGp...tKTllsNhpDIAKsLsRsPp.alhKalhtELGosGslDup.sRhllpG+apspplpslLccaI+cYVlC+sCpsP-Tclh+c..sRhhhLcCcACGucss	........................hhp.....Nsp.sss-ph..RachP..p..s.hhEGp......hKTlhsNhs.-ls+s.................LpRssp......al............hcahhsELGsp.us.h.Dsp....sRhll....pG..pap.s.p.plpslLcpaIpc.YVhCtpCc.sP.-.TpLphc......sc...h..hhlpCcACGtp..s.........................	0	216	369	528
+2398	PF01912	eIF-6	eIF6; 	eIF-6 family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes eukaryotic translation initiation factor 6 as well as presumed archaebacterial homologues.	25.00	25.00	26.20	26.10	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.15	0.71	-5.23	65	564	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	471	8	362	545	94	190.30	51	82.10	CHANGED	h+hshtsss.pIGVaspsosshsLl.shssscphhshhcppLs....lsl.lcToIuGopllGplssGNpsGlLVPshspDpElp....pL+pph..slpVphlcp.+hoAlG.NlIhsNDpsALlaP-lsc-stchIsDsLsV.EVh+toIAs.shVGShuVhoN+GsLVHPcsot-ElcpLsslhp...Vs.lssGTVNtGoshlGuGllsNshus	.......................s.RspFE.sss-lGVFupLTNsYsLV..ulG.u.SEsFYSsFEuELst.hIP.l...l+soIu.GoRllGRhssG.....N+pGLLVPssTTDpELp....HlRNsLP...Ds................Vplp..Rl-..E.RLSALG.NlIsCN.DaVALV..HPDl-+ETEEl.luDVLsV.EVF.RpTlAspsLVGSYsshoNpGGLVHPcTohp-.-ELSsLLQ...VP.lsAGTVNRGSslluAGhVVNDash.....................................................	0	122	213	298
+2399	PF03608	EII-GUT		PTS system enzyme II sorbitol-specific factor	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	26.90	26.70	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.95	0.71	-4.41	17	904	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	809	0	76	276	63	163.20	64	89.76	CHANGED	alsphAEsFlsLFptGGcsFluhlTGIlPhLlhLLlAhNulIthlGEERlp+lAphuu+Nsl....hRYhlLPllusFhLsNPMshohGRFLPE+aKPuaYsuAspasHs.sGLFPHlNPGELFVaLGI........AsGlTp..LG......hssssLAlRYhLVGllhshl+GhVT-hhTsalt+p	.....h.IT+uAEWFIGLFQcGGEsFsGh.l..........TGIlPLLIsLLVhMNALIsFIGpcRIERhAQ+sAsNPl....SRYLLLPhIGoFhhCNPMolSLGRFhPEKYKPSYYAAAu...CHohNGLFPHINPGE.LFVaLGI........AsGlTT..LG.......LP.h.GsLAlpYLLVGLVsNFhRGWVTDhTTAhhpK+.............	0	22	38	61
+2400	PF03609	EII-Sor		PTS system sorbose-specific iic component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.37	0.70	-5.09	72	5167	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1519	0	403	1910	44	235.10	33	88.43	CHANGED	M...phshlQhlLlslluhlsshct....hh.sphthapPllsssllGLlhGDlpsGlllGuoLphhhLGh.sslGuAssPDsslAulluohlslt........ustsh.ssAl.ulAlPlAlhu.hLshls+....olsshhhHtuD+tAccGshpslphhphhuh.lhtulphulP.shl...slhhussslpshlssl......P...p..alhsGLsluGGhlsAVGaAhllphMss+..chhPFallGFllAua..h..pls...llulullG..hslAl.la	................................M...shlQhlLls.l.h.uh.l.u..s......h.ct......hh...sthth..ppPllsss....llGLll.....G....D....lpTGlllGuoLpLlhLGh.sshGu.A..h.sPDsshu...u.lluT.shult.............ss.h...ss....p....sAl...u.l...Al....PlA....s.h.sth....Lshlhp....ol.sshh.h.H.t.AD+...tAcpu.shpu.lp....h....hp.h.h.uh.hh...hu.l.h.h.ulP.shl...slhhG.sshVpshlssl......Pt....hltsGLslAGGhlPAlGaAhll.p.h.Mh.s.+...p.h.hPaFhlGFlhuAa...h.....pls...............llulullG..ss.hAll.............................................................................................................	0	104	225	318
+2401	PF03612	EIIBC-GUT_N	EIIBC-GUT; 	Sorbitol phosphotransferase enzyme II N-terminus	TIGRFAMs, Griffiths-Jones SR, Yeats C	anon	Yeats C	Family	\N	20.90	20.90	21.50	21.30	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.17	0.71	-4.67	31	932	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	811	0	85	414	65	167.90	55	52.77	CHANGED	pslcIsKGsGGWGGPLhltPstp+cKllYlT.GGscPslsc+IuELTGhEAVDGFKsulP.--ElusslIDCGGTLRCGlYPKK+IPTINlhsTGpSGPLApaIsEDIYVSuVpscsI.............................pls-u.susssspststptstsp.............asssKKlo-Qps......ullu....+lGhGhGpVlusFaQAGR-oID	.....................p.pl+IpKGsGGWGGPLpl.sspst+KlVYIT.u.GsRPsIVDKlApLTGhpAlDGFKpu.P.-sEIusAlIDCGGTLRCGIYPK+pIPTINlhsTGKSGPLAQYIsEDIYVSGV+.-.sI..................................slssc..sss.p.ss.s.ss...........................pc..............YDTSKKIT.EQsc..........GllAKlGMGhGpsVAVhaQuGRDoID....................................................................................	0	27	42	68
+2402	PF03611	EIIC-GAT		PTS system sugar-specific permease component	TIGRFAMs, Griffiths-Jones SR, Mifsud W, Bateman A	anon	TIGRFAMs & COG3037	Family	This family includes bacterial transmembrane proteins with a putative sugar-specific permease function, including and analogous to the IIC component of the PTS system. It has been suggested that this permease may form part of an L-ascorbate utilisation pathway, with proposed specificity for 3-keto-L-gulonate (formed by hydrolysis of L-ascorbate)[1]. This family includes the IIC component of the galactitol specific GAT family PTS system.	20.80	20.80	20.90	21.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.46	0.70	-5.70	89	5120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	1917	0	376	2362	24	393.50	26	88.73	CHANGED	lpslLs..ssulllullshlGhllh++shscslpGslKshlGFlhlshGsu.llssslsshsphhpcsaulps......sl.ss.....sulsth.........auotsuhlhl.luhllNllls...+hTph+hlaLTGchhhahushlsslhhhhsh.ss...............hhlllhuulllulhhslhsshst.hhpclTs..ssshuluHhs......sluh....hlushlu+h......h...us.p..ch......ssEshplPKpLuhhp-shlsssllhhllallss..............hh.......................t...h..................sspshhh...hlhtulphAAulhll.tGVRhhluEllPuFcGIuc+llPs...............uhsALDsslsasa.uPsAlhlGFl.uhhstllslhlh.......h.........hslIl..P..GhlshFFsuusuulFuNuh...GGh+GslltuhlsGllhhhlshhh.....hshlushts.................................................................................tsshhushDa	................................ptlLs..ssslllsllhhlhhllh+.t.phscslcusl+shlGF.hhlss.shu.ll.s.s.s.lsPhs....p...th....sc....sa.sl.ph......slsDshhs..usls...............au.o....hu.hhhl.luh.l.l.Nllhl....hT...p...hppl.Lsschh.hhthhlss.hl.hh.hsh...ss................hhhhlhuullhulhhhhhushht.hhpclhs......ssuhuluHhp.......sluh....hls.t.hlsph............h.......ss.h..p....c............sh...-...s...hcl...s+plu.....hat...-shhsssllhhllhhlsshs..........................................h.................................stp..hh....hlphulsh.Asslhll.psVRhh......lstlsPshpGlsp+lhsp..................hh.ulDssllhu...sP.sslhhGhl.......llslhll.....................hslIl..P...Gshsh...Fs..shs.s.hsa.s.ssh...uuhRGslhtshltG.ll.hhhlslhh.....sshhushth.......................................................................................................................................................................	0	98	214	302
+2403	PF03613	EIID-AGA		PTS system mannose/fructose/sorbose family IID component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	30.80	30.70	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.44	0.70	-5.46	125	5271	2009-09-11 00:44:58	2003-04-07 12:59:11	9	5	1544	0	416	2104	46	264.50	36	94.84	CHANGED	tpLTK+D....lppsahRuhhh.psuaNYERMQshGasauhlPsL+KLY....ts..c--htpAlcRH.lpFFNTpPhh.ushIhGlslAhEEccusss........hsstsIsulKsuLMGPLAGIGDolFasTltPIhuuluuulAhpG.sllGPllahllasll....thhh+ahthphGYchGsphlspl.tuuhl...pplocuAollGlhVlGuLlss.hVplsh...shp.hstsp...................................................................tshslQs.hLDplhPuLlPlhlshhsaaLLpKK...lsshhlllhlhllGllhshlGll	...............................cLTKcD.....lpp.lhhR..S.hhh..QsSa..NYERMQuhGasauhlPslKKlY.....ss....c...--......h...t.pAl++H.L.p.F.FNTpPal.sshlhGlslAMEEpcu....sss..............h.ttuIpulKsuLMGPLAGlGDslFW.hTlhPIh.....uu...luA..uh.A........h..........s.G....sl............lGP...l..l..FhllaNll....phhh+ahhhphGYchGsshl.pch....uuhl....pplocuASILGlhVlGuLlss.a.V.p.lsh.s.l..p...h..s.t.sp..........................................................................................p.s.hslQs.hLDplhPuLlPLhhThhhaaLL+KK...hsshhlIhshhllGIlsphlGlh.......................................................................	0	107	235	331
+2404	PF04873	EIN3		Ethylene insensitive 3	Mifsud W, Moxon S	anon	Pfam-B_4883 (release 7.6)	Family	Ethylene insensitive 3 (EIN3) proteins are a family of plant DNA-binding proteins that regulate transcription in response to the gaseous plant hormone ethylene, and are essential for ethylene-mediated responses including the triple response, cell growth inhibition, and accelerated senescence. 	21.40	21.40	22.00	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.44	0.70	-5.19	59	958	2009-01-15 18:05:59	2003-04-07 12:59:11	8	17	628	1	88	945	0	256.50	30	39.71	CHANGED	EE.lc++...-Qh.l+...+p+php.hhts+Ess....ssupKss.............+spEQhp++phScA........h.thclsNh.GFh.s.sssssK..phssssLp...+Eclcpsh.Gshtlus........pscsLlhusscs..ps...cpospssolphlsDTshG.QtS.SLLpAth.tptpssPppphsLptultsP.............cELhas....suKDppssstsaKcP...........LpstlpHh.p.s.hchccpthcophLQs..KhSpRpSFAhhus.sp.Ec.ssplhsc..ot....shpc....pSPclslpsspc.-sp......................sccEschp.cspshcsss...........................................shshssp+c.csu-.sphs.p....tlsthCpsoQhpus........-ochhhss+pulsQs.h	............................................-Ehcc.t...pph...l+...+tpp.p...hh...pp....................htspKtp..............................psp-phpcphhscs.....................h..hplsph.uhh.s...ppsc....hsssshp...t-.t.p.ph.tshthsp.............p.pphh.....uttps.........ttu...tshpl..l.-Tsh..s......Slh.s.h.....t.pss.s..p....phs......hh....sP.............pE.h.s.....spptt...........shcp............ht..t.lpp...p.s..chcc..hpophLQs..+hot+pohshhu..tp.p..shphhst......s...........s.pp....tus.psshp.s.t.p.c..-sp......GpcEsp..p...spshps.h....................................................s.hshsp.p.c.p..p.ssc.....shhs.p..th..shhC.t...s.t.h..t.t.p.-hphhh..sp.uhspp...................................................................................................................................................................................	0	10	42	60
+2405	PF03317	ELF		ELF protein	Mifsud W	anon	Pfam-B_3282 (release 6.5)	Family	This is a family of hypothetical proteins from cereal crops.	25.00	25.00	25.10	147.50	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.85	0.70	-5.11	2	19	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	18	0	3	15	0	252.30	77	96.73	CHANGED	MT.shhR.........hhFSo.St....Fpshhhphp.+h.hI.....shIhF..lCl....Fhh...IhhFlsh..IlLPIlphFu....sSFLITLPPElQDPQALAHLtGLNFYLSLYEQDPtWVsFIQpELNHNTPLEDIPGRL+LFLMEE+hSshR.DlIQEFlALYtR.GshLPlEPYLl-tALRSYLDpI+ATDsFolLQAuYQDLR-pEtGShFFRDsVSHNRDhLEApSutRphlEVEpp.hapcI.+upApLERsEapHsL.lFp.EDh+RthE	.MpNh..............VRWLFST.SR....FTsFYhahCIKFPhIY....shILFS.lCl....FhF...lsRFI.h..ILLPIhpLF.u.....uSFLITLPPEIQDPQALAHLAGLNFYLSLYEQDPGWVTFIQNELNHNTPLEDIPGRLKLFLMEEKLSSMRQDVIQEFVALYQRlGPYLPIEPYLVDEALRSYLDHIHATDSFTVLQASYQDLRENEGGSVFFRDAVSHNRDLLEAESSARRCLEVEQRIRWEEIPKSKASLERAEHEHALDLFKSEDLRRELE.	0	0	1	2
+2406	PF02323	ELH		Egg-laying hormone precursor    	Bashton M, Bateman A	anon	Pfam-B_953 (release 5.2)	Family	This family consists of egg-laying hormone (ELH) precursor and atrial gland peptides form little and California sea hare. The family also includes ovulation prohormone precursor from great pond snail. This family thus represents a conserved gastropoda ovulation and  egg production prohormone.  Note that many of the proteins present  are further cleaved to give individual peptides [2]. Neuropeptidergic bag cells of the marine mollusk Aplysia californica synthesise an egg-laying hormone (ELH) precursor protein which is  cleaved to generate several bioactive peptides including ELH,  bag cell peptides (BCP) and acidic peptide (AP) [1].	19.60	19.60	21.00	20.50	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.68	0.70	-5.23	4	25	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	7	0	1	41	0	116.80	44	91.91	CHANGED	Mp+Ps.tssssh..llhCLhLSoLCsSSpSsuVHG+sFsspRAVK.pus.lV.SstD......stN.......-t.-csst.h.sss--..psEKpRLphtKRRlRFs+R..c.uth+.h.hpthshSADEN..FDLSN-DGA..QRchRsPRLRFYslRKRAAGs.EpSEspNPETESH...SRRKRSsLT.PSlpSLtpSLESGISKRISINQDLKAIsDMLLsEQhptRcRhLAsLRQRLL-hGKRuSs....VuLhsu-ht.-tRph	.........p..............................................................................................................................................................ltK+...t.ptuEt.p.p.cS....Shp.RSh....s.PS......pu.E.th.K.ISIsQDlhs.sp..h.tpht.Rpp..tsLhphhhph............................................................................	1	1	1	1
+2407	PF00964	Elicitin		Elicitin	Bateman A	anon	Sarah Teichmann	Domain	Elicitins form a novel class of plant necrotic proteins which are secreted by Phytophthora and Pythium fungi, parasites of many economically important crops. These proteins induce leaf necrosis in infected plants and elicit an incompatible hypersensitive-like reaction, leading to the development of a systemic acquired resistance against a range of fungal and bacterial plant pathogens [1].	25.00	25.00	25.10	26.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.96	0.72	-4.04	87	406	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	40	16	173	325	0	89.40	32	49.01	CHANGED	ssCossp.......lsslhsss.h...ssCu.....pss.s.hshhs.s..sossphtshCsuosChsllsslhshs..sD..C.....slshsu..hshpphlsshhstCs	........................sCosop....hsslsslLosssh...spCu.....sDS..G....Yshlss.s.s...h.PTssphphMCuSou.Cpshlsplhuhss..PD..C.....slsh.uGhhhNlhphssshtspCs.............	0	59	101	173
+2408	PF03789	ELK		ELK domain 	Finn RD	anon	Pfam-B_3136 (release 7.0)	Domain	This domain is required for the nuclear localisation of these proteins [1].  All of these proteins are members of the Tale/Knox homeodomain family, a subfamily within homeobox Pfam:PF00046. 	21.30	21.30	21.40	22.10	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.33	0.73	-6.39	0.73	-4.00	28	1671	2012-10-04 14:01:12	2003-04-07 12:59:11	8	7	111	0	131	525	2	22.00	75	11.86	CHANGED	ELKcpLh+KYuGaLusL+pEF.	.ELKDpLLRKYSGYLSSLKQEFh..	0	14	79	110
+2409	PF01151	ELO	GNS1_SUR4; 	GNS1/SUR4 family	Finn RD, Bateman A, Kerrison ND	anon	Prosite	Family	Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and  sphingolipid synthesis [1].  Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum.   Yeast ELO3 (Swiss:P40319) affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1 [2].	21.00	21.00	21.50	21.10	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.99	0.70	-5.08	181	2001	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	384	0	1301	1987	48	227.10	27	79.46	CHANGED	hhhss.h..shhlhshYlh...hV.....................hhGs.chMc....sR..c.......Ph............................pL+thhhlaNlhlslhShhhhhthh........t.hshh..h...........................................uhaphhC...............................................s.tthtts..hssaah..a.lSKhhEhlDTlFhlL+..........KK...ploFLHsYHHsshhhhsahshphh.suu..thhhh.hlNshVHslM.......YhYYhls..uhu...........h+.h..ha..KcalTphQllQFllsh.hhshhshhh....................................................................................................................sC........hh.shhhsh.......hhhhoalhLFhsFah.psY..h+pp....ptp...p	.............................................................................ts.h.sh.hhhhhYlh...hl......................hhG..c.hMc..............sR.......p......Pa......................................pL+t.hhhl...aN...hhhslh....Shhhhhthh..................hhthh..............................................shaphhC.................................................s.t.tht.t..hhhh.h..h..h........ahhoK..hhEhhDTl..FhlLR.................KK......ploFLHsYHHsshh..h.h.s.W..........hs.h...p...hh...su.u............t...hhh...h.hlN..hVHslM..........YhYYhlu....uhu...........hp...hhW...Kcal..TthQllQFllsh..hhshhshhh.........................................................................................................................sC...........hhhhhhhhhhhshhhLF.hpFahpsY.hpttt...t........................................................	1	477	666	1080
+2410	PF02488	EMA		Merozoite Antigen	Mian N, Bateman A	anon	Pfam-B_924 (release 5.4)	Family	This family represents the immunodominant surface antigen of Theileria parasites including equi merozoite antigen-1 (EMA-1) and equi merozoite antigen-2 (EMA-2) [1]. The protein shows variation at a putative glycosylation site, a potential mechanism for host immune response evasion [2].	36.00	36.00	43.70	94.20	33.00	35.10	hmmbuild  --amino -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.62	0.70	-4.90	10	417	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	56	0	2	413	0	240.60	65	91.16	CHANGED	K-cKcDLslDVshoSh-NVTlsss...-AsslVhTA+-GaRFKTLKVGDKTLYsVDTSKaTPspsa+LKHs--hah+LsLcsApPlhFKKKGDKEWsEhcaAsYYD-VLFKGKpt.K-LDsSKFsDsuLFoossFGoGKKaTFpssFK.sSKVsF-cK-VGcscpAKaL-VhVYVGuDsKKVVRLDYFYsGDuRlKEVYFcLtD-KWs+lEQs-ANKsLHAMsooWshDYKPlVDKFSPLAVhuuVLIVuuuslYa	.t.EEKKDLsL-VsATpsENhTVsso...suNcVVaTAp-GaRF.KTLKVGDKTLYTVDTSKFTPTsAaRLKHs--LaFKLsLppAKPLlFKKKoDK-WVpFsFupYLDEVLWK-KK-.K-LDASKFsDA.uLFsu-AFGTGKVYsFhGsFK.lpKVhFEcK-VGDssKAKYTuVKVYVGoD-KKVVRLDYFYTGDERFKEVYFKLVDsKWK+lEQSEANKDLHAMNsAWPhDYKPlVDKFSPLAV.....................	0	0	1	1
+2411	PF01105	EMP24_GP25L		emp24/gp25L/p24 family/GOLD	Finn RD, Bateman A, Wuster A	anon	Pfam-B_803 (release 3.0)	Domain	Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains.  This domain corresponds closely to the beta-strand rich GOLD domain described in [2].\	 The GOLD domain is always found combined with lipid- or membrane-association domains [2].	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.10	0.71	-4.57	232	2288	2012-10-03 07:10:23	2003-04-07 12:59:11	19	33	357	5	1454	2124	14	176.60	21	79.83	CHANGED	uhphplsss...ppc..Ca....h-pl..pp.sshlthpapl......sss...............................hslshp.........lp.....t.......ps....p.....hlhpp.ptp..pt..t...........pasFsu.p...................................psG.pYph.CFpsp.sphtt...............................ptlphclph.......s..tt..........................htp......hsp..ppclps..lpp............................plpp.......lppplpplpppppah+tREpph+sts-usspRlhhaSlhplhlllshuhhQlha..L+paFp	...........................................................................................................hhh.lss...t....ppc....Ch....hcpl.........tp..ss..hlh..h...p..apl...........pts....................................................t..hslshp..........................lp..................................ss....tp.....................hlhpp..ptp..st....s.........................pas..Fsu..p..............................................psG...p...a.ph.CFpsphsshst...............................ppVp.hclph................u...pt..p..................................................................htp........htp........ppclps..lpt.......................................................................p.l.pp............lpptlpp..lpcp...ppah+t.R..EtphRsts.......EssssR.Vhh....aSlhphhlllshuhhQlhhL+paF...................................................................	0	470	751	1133
+2412	PF04493	Endonuclease_5	Endonuc_V; 	Endonuclease V	Bateman A, Wood V	anon	Wood V	Family	Endonuclease V is specific for single-stranded DNA or for duplex DNA that contains uracil or that is damaged by a variety of agents [1].	20.00	20.00	20.30	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.19	0.70	-4.98	14	1175	2012-10-02 11:25:59	2003-04-07 12:59:11	9	7	1072	10	386	811	48	194.60	45	85.13	CHANGED	h.p-lpp+lshpsphpp..ph..chlAGVDlua....cpscuhushVlhshsshcllcptsh.hsclshPYlPGFLuFREh.hhlthlcpLtpc.c......................llllDGpGlhHPR+hGlAoHhGllLshPTIGVAKphLps....shhp.pst.........sshp.lh......suphhGtsht.ohpsspPlalSsGsphslcsslclspphhps.h+lPcssR.ADhho	.........................................plt.pp.l.hp.s.ph.s.....t........ss..phluGsDVuFc........psG-lspA.A.hVl......L.c.....a.....P.....o............L.........-.l.V.EhplA...cl..sso..hP.YIPGFLSFREh...PuLLsAh...c....t....L....s....p...+...P.D......................LlhVDGp....GIu............H.P.R...R......h.GlAS..Hh..G..lLl..D..l..PTIGVAKp+LsG....capslssc..............................................Gu.hsP.L.hc...............cGEp.lu.....hV.hR.....o.......+.......s............p.........s..p.....P..........LFlusGHRV.Sl-............oAlshVp+Chps..YRLPEPTRh.ADth.u......................................................	0	138	250	323
+2413	PF02945	Endonuclease_7	endonuclease_7; 	Recombination endonuclease VII	Finn, RD	anon	Structural domain	Domain	\N	23.60	23.60	23.80	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.62	0.72	-4.27	16	283	2012-10-05 18:28:12	2003-04-07 12:59:11	10	5	233	14	41	269	148	84.50	31	34.34	CHANGED	tp+htthYsl....ohccht.tlh-tQsG..pCtl..Cp....s..tpsh....slDHDH.....csGh.........VRGlLCssCNp.hlG+..h................tDs.chlpp..hhsYLcs	............................t...........pph...tlhptQ.........su...pCsl..Cpt.........ht...t..tp.ph..................slDHDH..........pTGh...........VRG.lL..CssCNt.sl.Gph...............tDs......phhpphhpYLp.t...................................	0	8	21	40
+2414	PF04231	Endonuclease_1	Endonuclease_I;	Endonuclease I	Kerrison ND, Finn RD	anon	COG2356	Family	Bacterial periplasmic or secreted endonuclease I (EC:3.1.21.1) E. coli endonuclease I (EndoI) is a sequence independent endonuclease located in the periplasm. It is inhibited by different RNA species.  It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA. Its biological role is unknown [1].  Other family members are known to be extracellular [2].  This family also includes a non-specific, Mg2+ activated ribonuclease precursor (Swiss:Q03091) [3].	25.00	25.00	26.30	26.00	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.59	0.70	-4.51	55	1440	2012-10-05 18:28:12	2003-04-07 12:59:11	8	32	1199	11	288	962	273	210.20	40	70.17	CHANGED	pohpphK.pLts...................psY..s...........................sss.hshYsGsshstp...........pu..sppsps..........schphEHV.......hPtpphupppp....................................pthpu.DlHpLhPssGpVNusRuNasFu.hs.................sss......phGpsshtssa.......cscphEP.cp.s+GslARshhYMstRY.s..............lclsctpp...............plhttWs+p.PVssaEppRNptIhp.hQGN+NPFl....spsp	........................................................t..t.hhhhh................................................................ps....css.....ss.hY..CGsphshpsp........thscht...sCGY.p.s.R.KspsR..........usRlEWEHV.......VPA.pFG+pppCWpp......G...............GR+sCtp....s..appM-o.DhHNLpPul.GE.....VNGDRuNa..au.phs.....................sGt......pYGp...Cs...hplcF...............Kp.+tsEPssc.s+GsIARsYFYMpspY..s.....................LpLSc.pps........................pLhpsWs+p.aPVos.WEp..cRs.....p........+Itc.......lQ.G.N.+.NPaVpcsp................	0	90	164	237
+2415	PF04667	Endosulfine	endosulfine; 	cAMP-regulated phosphoprotein/endosulfine conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4454 (release 7.5)	Family	Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19.  Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism.  In both cases the region occupies the majority of the protein [1,2]. 	29.80	29.80	31.20	30.00	29.70	29.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.95	0.72	-4.02	12	485	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	254	0	291	440	0	86.40	28	63.05	CHANGED	slshuphp.pE..............+lhKhYGtLsspKsh........Lp+Khpc.RKYFDSGDYAhtKuts.pspt....s.tt.t..hssssthccshh++thsuSss	.....................................................t.......p..-Et................+..lhthY...G.pL...ssKtsh..............................................Ltp+hpc...+KYFDSGDYshuKAtht...s.pphs..........................................ss....................................................	0	71	139	223
+2416	PF00322	Endothelin	endothelin; 	Endothelin family	Finn RD	anon	Prosite	Repeat	\N	20.50	20.50	25.30	20.50	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.73	0.72	-4.71	8	186	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	53	9	79	193	0	29.50	68	19.48	CHANGED	Rsc.hCSCsshpDKEClYFCHLDIIWhNTss	.....Rs+.RCSCsohhDKECVYFCHLDIIWlNTPp....	0	3	9	26
+2417	PF00555	Endotoxin_M	endotoxin; 	delta endotoxin	Bateman A, de Maagd R	anon	Arne Eloffson	Domain	This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.	25.00	25.00	28.80	27.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.47	0.71	-4.49	36	401	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	48	8	1	429	0	200.00	30	21.33	CHANGED	TpspLTRElYTDPlstss................sshs....oFsslEsshlRsPHLh-aLsplplaTst.pt........hpaWuGpplphphots....shlppshaGsps..stsstsls....ssps....lYRshopsh..h........ssshtulptspFhhssspttthssshhp......sss..shDohspLPspssp.........s.hpsYSHpLSalphhttphsp.t........hPsauWTH+Ssc	.........................TsoQLTRElYTsPlhtshst................psh......ohpslEsshl..RsPHLhDhLsp.lsIYT.st.pps............htaWuGHplthp.sss....sthshshaGshss..stssppls....hsps....lYRThSss..hh...th...........sp.ltslstscF..th....sss..thssshYt............tss....shDShsclP.Pp.s.ss.........Ps...h...puaSHRLSHlsh.hpts...tss.............sssF......uWTH+Ss-...................................................	0	0	0	0
+2418	PF03944	Endotoxin_C	endotoxin_C; 	delta endotoxin	Bateman A, de Maagd R	anon	Arne Eloffson	Domain	This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.	21.00	21.00	21.40	21.40	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.98	0.71	-4.07	80	512	2012-10-03 19:46:52	2003-04-07 12:59:11	9	13	62	9	5	538	2	134.80	32	15.34	CHANGED	ITQIPsVKuhpl.t.s...susVlcGPG.aTGGDll.hpssssh......hphpls......sshsppY.+lRlRYAS.ssshphtlphssssh........shshssThss.....st.....hp..Yp.sFphhshss......shsh.sssp.tplpl......thpshsss..splhlD+IEFI..Pls	................ITQIPh.lKu.tl..s...s.....ssoVlpG.......PG.aTGGDllphpsssst............uplpls.....p.sshup+Y.RlRlR...YA.S...s.ss.....hphplshsspshs........phshssThs..s.....sss........lp....hs.s..Fphhshss........shsh..ssss....hsl.......shpshsus...splhID+IEFlPsp...................................................................	0	2	4	4
+2419	PF03945	Endotoxin_N	endotoxin_N; 	delta endotoxin, N-terminal domain	Bateman A, de Maagd R	anon	Arne Eloffson	Domain	This family contains insecticidal toxins produced by Bacillus species of bacteria.  During spore formation the bacteria produce crystals of this protein.  When an insect ingests these proteins they are activated by proteolytic cleavage.  The N terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members.  Once activated the  endotoxin binds to the gut epithelium and causes cell lysis leading to death.  This activated region of the delta endotoxin is composed of three structural domains.  The N-terminal helical domain is involved in membrane insertion and pore formation.  The second and third domains are involved in receptor binding.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.47	0.70	-4.96	38	632	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	108	9	79	668	0	213.70	28	25.79	CHANGED	lpsulslsuhlLush.h..PhuGhlhuhht.LlshlWPstsss....WchFlpplEpLIc.Q+Ischs+spAlucLpGLsssac.....hYhpuLcpWcpsssssps......pptlcppFpsh-sthpsulPtFslp..sh....p...lsLLslYAQAANLHLhLLRDuslaGp.cWGhspssls.......paYsc.hchhpcYosHClpaYNsGLspL+.........sos...hpsWhcYNpFRREhTLsVLDlVALFPsYDsRt	..................................................................................................................h...shslsthlLu.h..h........P.h...sG.h.l...h.s..ht.llshlW.....st......tsss..........Wc.thhp.plEpl...Is....Q+Ipp.hsp....spshucL....p.G.Lpshhp....................Yt.pshcp.W..p....ss.ssss......................tptlpppapshpst.hhst.l...P....Fthp....sa.............p.........l.LL.slYsQAANLHL.lLRDs...laGp..cW...G...hs....sssls.............................shhs.c........hpphhtpY.osas..lp.hYssGLpplt...............................tss....tpWhpa........s...p...aR+phTLtVLDllul.F.s.YD...t....................................................................................	0	46	71	76
+2420	PF03272	Enhancin		Viral enhancin protein	Mifsud W	anon	Pfam-B_4236 (release 6.5)	Family	\N	19.50	19.50	19.60	19.60	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	775	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.10	0.70	-6.62	14	631	2012-10-03 04:41:15	2003-04-07 12:59:11	8	24	223	0	27	514	0	333.10	25	62.04	CHANGED	hs.hsltlPslshPsWlpsss.shhulcHt+pPlshlltAushl+lRpsps........lTlclLNsscpTEcolss..sss.hphssptsSVsFVcpsh.sstssthc..VpaplsuphpsLPhYphGpsp..t.Fhsphs..spsssaual-hchlplLVP.sD+stlp...ttshslspLtsaYssIlpaYssLsGh........sptNh.s++YFsKADt.uGsGuAYYuptahApSssolp.haLpsossNWhsLHEIGHuY-htFs.spthht..EVWsNlhsDhaQYthhs.sE+.ppuhlYpsGp+spl-psIhshlsssh.sassWshhp+Lhhho.lh.ppuGcchhpphppphRph.pshshs.ppaplhshlssh.....sphDls.hhpLh.th..s.........................thp.tshhhtppshYPlppllssa-hht.....l+....hposasLVsssphht.....sslolphpIc-ss.......QIhGphhtlhcGschlhpsslssssphhhs.tlssGlYplhhPpGp.s+RYpls..............spYllVcsss.p.........hplpap.hstSslhsc.phplhGhsD.tlsAshhlshtpcplslplhsssPpstFsNphYaplsIcsssshph..hsh.t.sss..tpshhshch..ssshplhlacpcsspph.....ahssh.ss.psssahloppGlpptss.....ssttpplhs+IsphstaLsscsshLh.hpspl+DsIYLuhphl.sppp..ptLhppascalP....ph.ss.......pshshshhGhsphshlplphshshppsplhhtss.s.....t..hp.....Yhslph	...................................................................tphs.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................phphpGhuD.hphApls.h.spppc.c.hplslp..s..s..pPHsYFss..pYuoIpVhsps..Gphlap+chpG..s.ppp.ts.p.pp.hshp....sshplp.....laH.....sEs.t....Rlph.......shtsph.ppp.....Kpt..h.ap..lTppG.Lcp.p........................................................................................................................................................tp.............................................................................................	0	0	8	14
+2421	PF03386	ENOD93		Early nodulin 93 ENOD93 protein	Mifsud W	anon	Pfam-B_2931 (release 6.6)	Family	\N	25.00	25.00	33.50	26.60	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.65	0.72	-4.27	8	99	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	28	0	48	83	0	75.50	65	70.20	CHANGED	QKhAhAKpCS+EushAGsKAAAVAsVAoAlPTLASVRMlPWAKANL.N.TAQALIISoAAGhAYFIsADKTILusARKpS	.........Q+lAhAKcCS+EuslAGsKAAAVAolASAlPT.........LASVRMLPWAKANl.N.TuQALIIoTsAGhAYFIsADKpILuhAR+pS............	0	3	24	36
+2422	PF00113	Enolase_C	enolase; 	Enolase, C-terminal TIM barrel domain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.72	0.70	-5.45	11	7258	2012-10-02 01:07:48	2003-04-07 12:59:11	17	14	5866	108	1661	5284	3499	256.00	52	66.97	CHANGED	shlLPVPhhNVlNGGSHAGNcLAhQEFMIhPoGAsSFsEAhRhGuEVYHsLKullKtKaG.sAsNVGDEGGFAPNIpoNcEAL-LIs-AIpKAGYpG..KVpIuMDVAuSEFY..c-sKYDLDFKs.psc.S+hlou-pLsDhYcElspcYPIVSIEDPFDpDDW-uWsphTtphGpclQIVGDDLTVTNPKRlpcAIEcKssNuLLLKVNQIGolTESlpAschApcAGWGVMVSHRSGETEDoFIADLsVGLssGQIKTGAPCRSERLAKYNQLLRIEEELGupAhYAGcsFp+sh	...................................................................................................................p.hhLPVP..hhNlING.GsHA.s.N.s.l.s.h.Q.E..FM.Ih.Pl..GA...p.oFpEAlRh..GuElaH.s.L.Kp.lL..........K..........p..............+G................h.........sT..u............VGD...E................GG................FAP................s.l.........t.........s.........s...............c.-...............A..L.phIh.c..AIct...AG..YpsG............pclhl.......uh....DsAu.S.E....F..Y.............c...s.....G.....p.....Y.......s.h.....p.......t....c...s.........................................................t..hh........o................upchscahpp.Ls.p....c.Y....P....I.lS.I.EDsh.......sE....sD..W-GWthhT......pp.l...G.......p...+...lQ................lVGDDLF....V.TN.s.c.hL....t..c..G.I.c..p...t.....hu.Nul...L.....lKlN..............Q...IGoLTETlpAlchA.+c..sG...a.sshlSH.R....SG..E..T..EDo..hIA..Dl.AVuhssG...QI..KT.Gu..uRo-RlAKYNQ.Ll...R.IE-t.L...u..p........A.........a...G.t....h..........................................................................................................................	0	546	1007	1367
+2423	PF03952	Enolase_N	enolase_N; 	Enolase, N-terminal domain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.10	21.10	21.40	21.70	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.46	0.71	-4.22	190	6649	2012-10-02 11:54:41	2003-04-07 12:59:11	11	15	5507	108	1614	4840	2520	125.70	58	30.79	CHANGED	pIpplpAREILDSRGNPTVEV-VhhpsG.hG......RAuVPSGASTGppEAlELRDuD.....p+ahGKGVhcA......VpNVNshIussL.l..G.hc....st-QptlDphhl.cLDGTp.....NK..u+LGANAILuVSlAsA+AAAsshs.lPLYcYl	.............................................................IhclhuREllDSRGNPTVEs-Vhh...-....s.G....h..hG....................RAsVPSG..AS...T....G...p..........+EA.l...E..LRDGD....K..............sRYhGK.GVhKA..............VpNVNshI...Ass.l..l....G..hD...............sp-Q..ttID.phMI.c.LD...G..Tt........NK.....u+LGANAILGVS.L.....AlA+AAA.sttslPLYcYl.......................................	0	524	978	1328
+2424	PF03735	ENT		ENT domain	Bateman A, Hughes-Davies L	anon	Bateman A	Family	This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts  with BRCA2. The N terminus of this protein is found to be  similar to other vertebrate and plant proteins of unknown function.  This domain has a completely conserved histidine residue that may be functionally important.	20.70	20.70	20.70	22.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.12	0.72	-4.25	20	289	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	104	5	169	275	23	69.90	40	10.89	CHANGED	hcsp..l+pLEp-AYuuVL+AF+AQus.lSh-Kcplls-LR..................KELplSs--HRphlp+lssD-plpplRctppusss	..........ct.l+pLEhEAYsuVlpAh+AQu-..L.ohEKcsLlsELR..................+pLpI.SsEcHRt.lp+sssD-hlppItc.hts...s...........	1	42	89	127
+2425	PF01375	Enterotoxin_a	Enterotoxin_A; 	Heat-labile enterotoxin alpha chain	Bateman A	anon	SCOP	Domain	\N	19.60	19.60	19.90	20.10	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.63	0.70	-5.09	6	164	2012-10-01 23:25:29	2003-04-07 12:59:11	12	6	82	29	50	164	0	208.20	43	47.94	CHANGED	hsplhhFFI...hlu....ANs..haRADSRoPDEl+cSGGLhPRGpsEsa-RGTslNINLYDHARGTsTG.sRasDGYVSTohoLRpAHLhGQshLuuascYYIYVlAsAPNhFDVNGVLGs.YSPaPsEsEsuALGGIPaSQIhGWYRVs....FGsl-st.hcRNR-YRc-hacsLssAPupDGYpLAGFPssaPAWcEtPWtpa.AP.uCssss+ppssssCsptsspLupttLt-app+lKRplshh..hS..ps-hhusssh+DEL	.....................h.......................t...lYRu.D.s.RsP--I+puG..GhhPR.......Gpschh.p.cs.Tph...sh.......sLa-..HspGs..ps..........GhsR...h.s.D.GYVSTo......ho...lc.s.A..+..h.hu.p..s..hlu...s...hs......s......h..YIYsI...A.s.A..PN.MhsV............N...c....s...L......Gs..Y........SP..aPt.EpEhuALGGIPaoQIhGWYRVp...............................aG.sl-p.....t..hp+NctYcs..ch.a.pshs.h.Asuts...tLAG.FPs...pa..AWc.-cPWhpa..us.ss.t.p.t....c.s...sssCsttppphs.h.h.phpphh+.p..................................................................................................	0	3	37	40
+2426	PF01376	Enterotoxin_b	Enterotoxin_B; 	Heat-labile enterotoxin beta chain	Bateman A	anon	SCOP	Domain	\N	25.00	25.00	80.60	80.50	21.30	19.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.57	0.72	-4.16	5	107	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	28	276	1	108	0	95.80	92	83.02	CHANGED	TPQNITDLCAEYHNTQIYTLNDKILSYTESLAGKREMAIITFKNGATFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAISMA	.TPQNITDLCAEYHNTQIaTLNDKIFSYTESLAGKREMAIITFKNGATFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPpuIAAISMt.	0	1	1	1
+2427	PF02048	Enterotoxin_ST	Enterotoxin_HS;	Heat-stable enterotoxin ST	Mian N, Bateman A	anon	IPR001489	Family	This family consists of the heat stable enterotoxin ST from Escherichia coli. ST is a small peptide of 18 or 19 amino acid residues produced by enterotoxigenic E. coli and is one of the causes of acute diarrhoea in infants and travellers in developing countries. ST triggers a biological response by binding to a membrane-associated guanylyl cyclase C which is located on intestinal epithelial cell membranes [1].	21.10	21.10	23.10	22.70	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.23	0.72	-3.71	6	34	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	13	3	0	35	0	45.90	57	76.04	CHANGED	QETsShphuDu.SssIssEl.cKtCDs.psss....Es.sDW..CCElCCNPACAGC	..................................KtpIsh.s..ccCsh.Kpss....EshNsh..CCElCCNPAChGC	0	0	0	0
+2428	PF01417	ENTH		ENTH domain	Bateman A	anon	[1]	Domain	The ENTH (Epsin N-terminal homology) domain is found in proteins involved in endocytosis and cytoskeletal machinery.  The function of the ENTH domain is unknown.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.49	0.71	-4.26	72	1127	2012-10-02 18:21:09	2003-04-07 12:59:11	15	25	307	14	691	1760	5	121.20	40	23.47	CHANGED	hophphcVR-ATss-.sW.GP..osshhp-IuchTas..pph.clhshlh+Rl.........................................................s...cps+pWRplhK.........uLpLL-YLl+sGSE.....pslpph.+pplhhlpsL.ppFpa.h-p.pG+DpGhs............lRp+ucplhsLLpDs-pL	................................................................ophphKVR-ATs.sD.PW..GP.ou..s.l.M.s....EI.....A.....c.h...T........a......s.....h.....ts........a.t..E......I....Msh...la...+...RL............................................................p..-puKsWR+lYK..............uLpLL-YLl+sGSE........+V.s.p.ps...+c..s...l...a....h....I..psL....c..........sF....pa.lDc..pG+DQGhN............VRp+uKpllsLLpD--+L........................................................	0	203	350	539
+2429	PF00429	TLV_coat	ENV_polyprotein; 	ENV polyprotein (coat polyprotein)	Finn RD	anon	Pfam-B_145 (release 1.0)	Family	\N	22.50	22.50	22.60	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	561	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.24	0.70	-13.00	0.70	-6.06	16	3200	2009-01-15 18:05:59	2003-04-07 12:59:11	14	13	221	9	70	2514	0	268.00	25	83.52	CHANGED	llLhlLhh.........ht.ssP+pshslh.plhs.................phhP.h......shCsLuut..sshshsspss.sss..s.spsuhhss...............p..Csps.ph......stttstshYlCPspspsh..stpphGh.pssYs..sthtCppsG.....psYWpss.ohsh.olppsto.....................ttspssptpstsssLhlpFopsGppu....pshsWuhR..lahS.GtsPhhhhslphhhppl........p.lltpp.tPPsp.pPht.Phss......................................t.ssssphlsLlpusa.sLNhTsPshsp-CWLCLstu..PPaatulus.sshsspTsss....C.ssspatLp.spsos.shhhu.......sl.....PhsatshsN............ps...tttss..hLssssGohasCssshT.ChpTsl.NhooshClLspLhPclohhss-....l.s..psssRh+Rt.slulTLs.LLsGL...GIuuuluTGsTuL.Vu.....sppappLpttlcsDlptLppoIssLccsLsSLuEVVLQNRRGLDLLFhcpG..GLCtALpEcCCFYAs+oGlVRDphtKLpE+LppRp+lhpupthW.pGhhshSPWhpsLlpohhGPLllLLLlLhFGPCILN....+LspFl+	...........................................................................................................................................................h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ph.thtt...tpp......................................................................................................................................................................................................................................................................	0	14	16	49
+2430	PF00811	Ependymin		Ependymin	Bateman A	anon	Pfam-B_1391 (release 2.1)	Family	\N	25.00	25.00	26.20	25.30	24.20	24.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.67	0.71	-4.45	20	196	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	88	0	108	182	0	130.50	28	57.16	CHANGED	lEcssphNpopph.DlLlhFcE..GVhY-IDt+NcoC+KpsLppph+Ph-lPssATa.sEhhlGussh.tpGLcVchWsGc..lP-p+........GpYohpoTphGClPVops.Yps-ps...s.LhhSFa-lpstlcDP.pVFsPPu.hC	................h.........stph.-hlhhac-..GlhYpIs.pscpCpKpsL..p.p..sa...cPhclPpsAoa.....sphhlGus....tpulhVppWssc...hsstp........utY...s.s.p..s.s..s....ClPVpps...ahs....sps...........shlh..h..p..Fhslph..GIpDP.sVFsPPs.hC...................................	0	61	68	92
+2431	PF01404	Ephrin_lbd	EPH_lbd; 	Ephrin receptor ligand binding domain	Bateman A	anon	[1]	Domain	The Eph receptors, which bind to ephrins Pfam:PF00812 are a large family of receptor tyrosine kinases.  This family represents the amino terminal domain which binds the ephrin ligand [1].	19.80	19.80	19.80	20.60	18.70	19.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.49	0.71	-4.48	33	1131	2012-10-03 19:46:52	2003-04-07 12:59:11	14	44	89	57	480	825	1	167.20	52	19.47	CHANGED	EssLLDopsspu-L.GWhsaP.s.G.........W-EloshD.-ptpslRTYQVC..sV....hcssQNNWLRTsaIpR.psApRlaVEl+FTlRDCsShPusss..oCKETFNLYYhEoDp............sss...sshpcstatKlDTIAADEu.hsphc...........hssps.h+lNTElRslGP.....Lo+.+GFYLAFQDhGAClALlSVRVaYK+C	...............................................sLhDopt.t.u-L......uWhs.P.p...G...................WEElSthD.E.phssIRTYQVC..NV.......h-.ssQNNWLRT...saI.sR....cuA.p......R.......lalEl+FT...l.R.DCsS..lP..ss...h..G.....o....CKE..TFNLYYhEoDp...............s.ts....sthpEs.a...........hK..l....DTIAADES.FophD....................hGsRh.hKlN.TElRslGP................Lo+.+G..FYLAFQ.DhGAClAL.lSVRVaYKKC.........................................	0	50	89	238
+2432	PF01370	Epimerase		NAD dependent epimerase/dehydratase family	Bateman A	anon	Pfam-B_93 (release 3.0)	Family	This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.13	0.70	-11.31	0.70	-4.93	96	38903	2012-10-10 17:06:42	2003-04-07 12:59:11	16	146	5462	329	11522	75709	43322	233.20	20	69.25	CHANGED	lLlTGssGhlGutlschLhppuhc.........shshtppts..........................h..sDls.cpsslpchhppt...psDt....VhphAAtst...lttsh.ppstthhcsN....hhsshpll-uhp.........phsh.........h+hlhsoS.uplYGps..tt.....................h..sEsssh...tPhsP....YuhuKhhupthstsh......pcp..a.shpssshhhhNhhGPt........t.tthss+hlsthlpphh..........pup..................................lhhhG.......sGss.tRDalascDhscAhhhhlppsp.............spsaNlG	........................................................................................................................................lLlT.G.u..s..G...a.......l...G......u..p...l....s......p..t....L......h..p......p....G.hp......lh...................shs..t.s..t..p..t..t.......................................................................th.p.h..h.......s...D.....l......p......c.........t.......s.........t......l.......p.....p....h....h...p...pt........................D..s.......................V....h.......H..........h.........A........u......................s............h..........s...........t...........t..........s..........h........p..............p........s..........t.........t.........h.......h.....p.....s....N.......................l...h....u....o....h.....s........l.....l........c.....s....sp............................................................p.t.ss..............t+..h..l...a...s....S.......o.....s........s......l........Y...Gps.........tp.h....................s................................................................h.....s.E...s.psh............t.P.h.ss.....................................Y..u...h.....o....K..........h....h....s..E.......p....h....s...p...s...h...............................t...c...p......h......s.........h.....p........h.......s....h....h....R....h....h...s...s....h....Gst.......................t......s...p...h...l.....s....h...h...h...p...t..h...h.......................................................t.s.p....................................................................hh.l.h.G............sG.....p....t.....h....R.....s..........a....l......a..l.pD...h....s...pu.h..h....h....h..h..p.p.t....................t.hsh.........................................................................................................................................................................	0	3673	7370	9810
+2433	PF02350	Epimerase_2		UDP-N-acetylglucosamine 2-epimerase	Bashton M, Bateman A	anon	Pfam-B_888 (release 5.2) & Pfam-B_4862 (Release 7.5)	Family	This family consists of UDP-N-acetylglucosamine 2-epimerases EC:5.1.3.14 this enzyme catalyses the production of UDP-ManNAc from UDP-GlcNAc.  Note that some of the enzymes is this family are bifunctional such as Swiss:O35826 and Swiss:Q9Z0P6 in this instance Pfam matches only the N-terminal half of the protein suggesting that the additional C-terminal part (when compared to mono-functional members of this family) is responsible for the UPD-N-acetylmannosamine kinase activity of these enzymes. This hypothesis is further supported by the assumption that the C-terminal part of Swiss:O35826 is the kinase domain [3].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.11	0.70	-5.68	187	4483	2012-10-03 16:42:30	2003-04-07 12:59:11	14	13	3029	20	922	3343	2891	333.90	34	89.01	CHANGED	ptlppp..t.....hchpllsTGQHh.pchspphhc............tapl..ps-hp....Ls..pss.tshup.huphlhthpcllpc...pP.DhVl...VhGDssoslAuAlAAhhhpIP.luHlEAG.Rs.........................-hp.s.hPEEhNRphss+luclHFssTppupppLlpEG....h..........ssp.....plassGsssl...Dsl......hhstppltt.........sl..p.............hppphlLlThHRtpshsts..hpplhpslpsls...pp..ph..llashH.sPpspchl.............phlpph.s.......plplhpPLsahcalpLhppuphl............loDSG.GlpcEAss..ls.....hPslsl..R..sER.EuhttGs...shl.l.u..s.pppIlpulpphlts.....tthpthsp....PYG.-GpA.uc+Ilchlt	...............................................................t..htpp..th-thlssTuQH..ccMh-p...lhp............hFpI....p......sD.hs.Ls.......pss..psLs.ch.......Tup....hlttlc.pllpc............cP.DhVL...VaGDTs..oohAsuLAAh.h.............ppIP..VuHlE...AGLRoh........................-hh..s.h...PEEhNRplsspluc...laFu...PTcpu+.pNLlp.E.uh.....................spp..........pIalT.GN.ss.l.DuL..............hhs.h.pp..h.....tt.....................plhtp.....................tsc+hlL.l..T...s....HRc..E.....N.h..s..p.s.....hc.p...lhpA.l.p.pls...pp....cht..llaPhH.....sP.p.s.pch.l.............pc.h.ltph..p.......plpLl-.P.l..sa.h.c.Fh...tLh.....p..cu.h.hl.............l...T.DS.....G..G..l.Q.E.EA..Ps..LG.....pPsLll.........R....s.s..TE.RPE....u......l...p...s..G.T......stL......lG....sc....tppIh.ptsppLlpc...........ppth.pp.hsp..stNPY...G..D.G..p.A.upRIlchl.........................................................................................................	0	306	604	780
+2434	PF00758	EPO_TPO		Erythropoietin/thrombopoietin	Bateman A	anon	Pfam-B_990 (release 2.1)	Domain	\N	25.00	25.00	25.90	25.90	23.50	19.90	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.96	0.71	-4.61	6	114	2012-10-02 01:28:15	2003-04-07 12:59:11	13	1	54	9	46	138	0	150.00	39	69.31	CHANGED	sRLICDSRVLERYlLEA+EAENsTMGCuEussLuENITVPDTKVNFatWK+.EspppAlEVWQGLALLSEAlLpuQAlLANSSQssEsLQLHsDKAlSGLRSLToLLRsLGsQpEthSsP-sss..sAPLRslssDslsKLFRVYuNFLRGKLpLYTGEsCRRGDR	.....t.lCDsRVLp+alhEA+-AEsthhsCsEsssLspslsVPsTclsahtWKphphp...ppA.EVhpGLsLLtEAlhtupu.LusostssthhQLHsD.pu...lpsLtSLpuLL+sLss..ptt...hos.....scs.....ss..hhshp.phhhsshpcLhplhsshLpuKhtL.sst..sspptt.................................	0	2	4	11
+2435	PF00275	EPSP_synthase	EPSP_syntase; 	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	Finn RD	anon	Prosite	Family	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.42	0.70	-6.05	23	10932	2012-10-02 15:27:11	2003-04-07 12:59:11	15	37	4830	176	2360	7857	8210	390.10	27	90.26	CHANGED	lpsssplsGpV.plPGsKShosRslllAALusu.....oplpNlLcucDspphlpsL+pLG..hhphppppsshhspG.htphpss....t.hslhhGNuGTshR.Lsuhhuh.ts........lsLsG-splppRPlspllcuL+phGAcIphppstshsPltlps...hphtslclpssluSthlTuhLhhAshhAcu..sshlps..hsscPplshThphlpphGsplcs.sstp...hhlcGspp...hsu.pahV.uDtSuAuaFlsAAAlssG.pVtlpslshsslp.u...hlt.hLcchG....upls.......hs-stslshtt.........hcshsl..slpshsD.uhslAhhAtFAp.......usoplcshtplRhKEo-RlhuhusELp+lGucscEt............DGh.......psshh.....LpsuclpoatDHRhAMuhuLsu..sps.........tshIccspshs+oaPsah-pL	......................................................................h..s.p.LpGpl..plsG.tp.ushsll.h.A.u.L..h..s.sp....spl.p.s.l...p..h........pDlt.shhph..lp...tLG..............s........p..l....................t...................................t..............s..............s...........s........h.............h.....h........s...........s...s..........t..........h.......t.....s.........h.p............ss...........ph.............s...h...p....h...tsS...hhshts.Lhuthut..s........................plsl.sG...ss.s........l.u.....p....RP.........lchh..lcuL.c.t.h..G.A.p..l.......p........h......p......p......s.........h...........h.ss.hp...........................tpL.p..usc........lh.h...s...h.....s...S........st..sTtslh.h...Au..hh..AcG..............pT.hlp.....s.....hspcPp..l.sc.htphLpp.hG....u..c....l.........p.....s.................s...s..sp.......................lp.l..........p....G......spp.............Lt.u.......t.p...a..pV.s..Dt.p....Auha..l..s.A...........A.........Al........s....s.............G...c..............lhl....p.s.s.......hh.......p.......php............hlh.hLcch.G............splp.......................h.t.c.........s..h..lt.hptt....................hc.h.t..s.l.......sl.p...s.....hs...cs.uhsh..shtu.hst................................hh.shhc.Gsu..lp.p.h.-.phhh.hss..ELp..+h..G.A.c..l.p...ps.................cs.hh...................................................hh.sst....................L..p..G.A..p.V....t..u.h..DhRhuhuh.slAuL...hu.p.G...........s.plpch.tpls+uYsshhccL............................................................................................................................................	1	809	1563	2026
+2436	PF03736	EPTP		EPTP domain	Staub E, Mistry J	anon	Staub E	Repeat	Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section.  The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold [2].	20.60	20.60	20.80	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.87	0.72	-4.21	71	1712	2009-01-15 18:05:59	2003-04-07 12:59:11	12	64	48	0	784	1271	21	45.40	22	22.68	CHANGED	ppFhphQsls....psshshcshsl.sschalllup.hu..top......lhcWss	............pFhpaQsls....hpsshshchapl..s......s......c.............alslus.hs.......top.............lacWs........................	0	61	129	324
+2437	PF01133	ER		Enhancer of rudimentary	Finn RD, Bateman A	anon	Prosite	Family	Enhancer of rudimentary is a protein of unknown function that is highly conserved in plants and animals. This protein is found to be an enhancer of the rudimentary gene Swiss:P05990.	25.00	25.00	25.70	34.10	20.90	24.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.11	0.72	-4.32	13	234	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	144	7	154	192	0	97.70	53	65.02	CHANGED	MSHTILLlQso.p+h-oRTasDYESlspshEGlC+lYE-+LKchNPssssITYDISQLFcFIDsLADLSsLVacpsTtoYhPasKpWIKp+lYthL+ppAt..p	.................oHTILLlQPs.p+.-sRTYsDYESVs-CME.GVCKhYEE+LK+..h.....N...P......sssoITYDISQLF-FIDsLsDLSCLVYctsTp............o.YtPaNK-WIKEKIYhlL++pAt..s...................	0	44	65	117
+2438	PF00810	ER_lumen_recept		ER lumen protein retaining receptor	Bateman A	anon	Pfam-B_1387 (release 2.1)	Family	\N	21.50	21.50	21.50	21.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.90	0.71	-3.71	61	726	2012-10-03 12:15:12	2003-04-07 12:59:11	13	9	338	0	498	703	22	138.40	43	59.98	CHANGED	SCsGlSh......KoQhLYslVFssRYlDL..ap.sah...ShYN......slhK.....lhalsoohhslYlh..hhpa+t...TY-cph..DoFplp.aLlssshl...........................................LAllhs.....ppa......phh-lhWoFSlaLEuVAILPQLhhlp.+o.scsEslTu+YlhsLGhYRsLYlhNWIaRY	...........................SssG.lShKoQ.LaulVa.......s.s.RY.LDL...ap.sah..........ShYNo..hhK..................lhalssohh.slYhh...hhca+s.....TYDtsp.....DoF+.........l.........t.a.........LllPshl...........................................L.uhlhs.........pca..........................shhEl..lWoFSlaLEuVAILPQLhhlp..+T..u........c....sEslTuHYl.FsLGhYRsLYlhNWlaR......................................	0	174	285	401
+2439	PF02732	ERCC4		ERCC4 domain	LOAD	anon	LOAD	Domain	This domain is a family of nucleases. The family includes EME1 which is an essential component of a Holliday junction resolvase [2-3].  EME1 interacts with MUS81 to form a DNA structure-specific endonuclease.	20.70	20.70	20.80	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-11.07	0.71	-4.43	159	1301	2012-10-11 20:44:43	2003-04-07 12:59:11	10	39	620	18	812	1250	227	143.70	22	21.21	CHANGED	lDsRE..hp.st............l.phlpphu..h.phphpsLt..........lGDalh.......ts.......................................phhlERKs.hs..Dhss.....Slh...c..sR..hhpQh......pcLp..p............thpp....s.hlllEsptthhtt.....................hp.............pss.........................sl.....................psslsplplp.h.sltlhhops.hp-ouphltph	............................................................................lD.RE...hp.st..............l.phlpphs......l..phthp.p.L.s..............l.GDalh......ss.................................................................................................phhVERKs.ls.......DLhs.................Slp.........s......uR.hhpQh....................tclp....p.................thpp....................s.hlllE...tpt.st.h.p..............................................................p...................................................sl.......pssLsplplth..thtlhhops.pposphlh...........................................................................................................	1	273	458	660
+2440	PF04404	ERF		ERF superfamily	Aravind L	anon	Aravind L	Family	The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to ERF [1].	25.00	25.00	25.00	25.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.21	0.71	-4.70	43	704	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	504	0	89	596	339	157.60	21	65.36	CHANGED	hhpshsplpppl.t.pKs......sphhph.....pYt..shc-I....lcsl+sllscpGl.hh.hsp.............................spthlplpshlhc.tsu.t-phps.h.tp.......s.sKs....ssQssGouloYA+RYsLsuhFuIsscpDcDs.....................ttptppppsppppssppppp..ttchhpppsp	......................................tthtplptp.l..s..t...pKs...............sph.hpY................pYt..sh..psI....lcslcsll..p..pps..Lhls.pt.sh............................tthhhplpss..hhs...ssG....pphss.hhsp.....................ptsKs....sssQss.GuuhoYu+RYsLsuhhs.Iss.-..c...DsDs....................ttpptpp.tspp.t.p........................................................................................................	0	29	53	69
+2441	PF03463	eRF1_1		eRF1 domain 1	Bateman A	anon	Bateman A	Domain	The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.	21.20	21.20	21.30	22.40	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.36	0.71	-4.58	119	1096	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	518	26	713	1080	196	131.10	28	32.75	CHANGED	h...hppshc.hchcthlchl.cppschhpLhsLlhssDp.hupsh+pl.pc...sssh.....puppsp.....................ppV.sslshtlp+lca....sstsuh....................................lhhsGtlhpt.....sphsphcolslEss..cslslh+.........phDshhhpchhcsh.p	.........................................................pcslc..hch.ct.hlphl.psp.s.....sh..hphhsLlhPscp.h..up..sh+hl.pc................ssshpucssp...............ppVhs.slo.shp+l.ch..............sP.suh........................................................lhhs......Gpll.....sc..............c..s+.tp..hhol-hE..P.....+...s..lshph..................hhhDsthh.schhpth............................................	1	236	416	593
+2442	PF03464	eRF1_2		eRF1 domain 2	Bateman A	anon	Bateman A	Domain	The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.	24.10	24.10	24.10	24.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.50	0.71	-3.83	35	1105	2012-10-02 16:33:16	2003-04-07 12:59:11	10	12	531	23	724	1082	171	129.50	31	32.44	CHANGED	phuhlllDcstAplullpupshcllpchssslPtK+ttGuQSth+at..htcttcpah+cVuEtsspthh.......ppsplculllAGPGhhKsphhppthhctchtp........thlh.llDlShuuctGlpEslcp..uschLsc	............................huhllh-t.stAhhuh.l..pu..s......s.pcllp+hss.slP+K+t..pGG...pSsh+at.......htcthcpahcclu-thsph.h..................shsslpullLAGsu.hKs-hh..pt......hhctchps...........................phlh.lVcsSh..Gscp.Ghppslch..sschLp................................................	0	236	422	602
+2443	PF03465	eRF1_3		eRF1 domain 3	Bateman A	anon	Bateman A	Domain	The release factor eRF1 terminates protein biosynthesis by recognising stop codons at the A site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl transferase centre. The crystal structure of human eRF1 is known [1]. The overall shape and dimensions of eRF1 resemble a tRNA molecule with domains 1, 2, and 3 of eRF1 corresponding to the anticodon loop, aminoacyl acceptor stem, and T stem of a tRNA molecule, respectively. The position of the essential GGQ motif at an exposed tip of domain 2 suggests that the Gln residue coordinates a water molecule to mediate the hydrolytic activity at the peptidyl transferase centre. A conserved groove on domain 1, 80 A from the GGQ motif, is proposed to form the codon recognition site [1]. This family also includes other proteins for which the precise molecular function is unknown.  Many of them are from Archaebacteria. These proteins may also be involved in translation termination but this awaits experimental verification.	21.20	21.20	21.20	22.20	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.31	0.71	-3.81	34	1128	2012-10-10 14:40:03	2003-04-07 12:59:11	10	12	530	29	741	1099	188	117.00	33	29.44	CHANGED	hhpEpcllscFhcplup..DsshssYGhc-lhcAlEhGAl-sLLlh-sLhppc.h..+p............................................h-pLscpscphGuplhllSscpppGpQl.cuFGGIuulLRapl	..................................hpEp+llscaacclsp..Dsu.+ssYG..............hc-sh+AlEh..GAV-....s....Lllh-sL.psc.h.h+pp.............................................................................h-hLsc.......p.h+ph.G.u.plcll....osc..pppGpQh.cuhGGIuulLRYtl...................................	0	245	432	616
+2444	PF03734	YkuD	ErfK_YbiS_YhnG; 	L,D-transpeptidase catalytic domain	Bateman A	anon	COG1376	Domain	This family of proteins are found in a range of bacteria. It has been shown that this domain can act as an L,D-transpeptidase that gives rise to an alternative pathway for peptidoglycan cross-linking [1].  This gives bacteria resistance to beta-lactam antibiotics that inhibit PBPs which usually carry out the cross-linking reaction.  The conserved region contains a conserved histidine and cysteine, with the cysteine thought to be an active site residue.  Several members of this family contain peptidoglycan binding domains.  The molecular structure of YkuD protein shows this domain has a novel tertiary fold consisting of a beta-sandwich with two mixed sheets, one containing five strands and the other, six strands. The two beta-sheets form a cradle capped by an alpha-helix. This family was formerly called the ErfK/YbiS/YcfS/YnhG family, but is now named after the first protein of known structure.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.41	0.71	-3.93	173	11311	2012-10-02 23:30:06	2003-04-07 12:59:11	9	81	3160	8	2612	8151	1995	140.70	20	42.83	CHANGED	pthlhls.....hsp.......phhhh..hc.ssp....hh.hp..h...........lssG......................p....ttTPhGtaplt............h..t....h..............tt...................................................................h.h.ttts....lhlH..ss......................................t.t..SpGClpl.t.............................pcspplhsh................lt.....................................hu.s..............................Vhl	...........................................................................................s..hlhls....hsp........ph.hhh....hp...ssp.................hl..hs..hs...........lu..hG...............................p.sptT...P...p.G.s....h.p.lp.............................p+t.h.sP.s........p...s..s...h...h..h..t..............h.........h..........................................................................hh.h.t.h.h.s.s.s.s......hhlHs..sss.s...h.................................ps.....SpGClRl..p..s............................pchp.t.L.ash................l..................G.s...........V....................................................................................................................................	0	765	1615	2089
+2445	PF03694	Erg28	UPF0143; 	Erg28 like protein	Bateman A, Kerrison ND	anon	SWISS-PROT	Family	This is a family of integral membrane proteins, which may contain four  transmembrane helices.  Members of this family are thought to be involved  in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p  (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the  endoplasmic reticulum or may facilitate interaction between these proteins [1].  The family contains a conserved arginine and histidine that may be  functionally important.	22.20	22.20	24.60	27.20	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.45	0.72	-4.06	21	246	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	215	0	172	225	0	113.00	34	77.67	CHANGED	hGhLshWLlhlSlluhhNolQsYhs..hphoc+lYs...............................scs....sps.osLpuRsFGsWThloullRhauAapl.pspslYpLshhoaslAhsHFhoEhLlF+TspLstshh.....uPLlVuos	.................................shLstWLlhVSlluhhNohQsahs..hthsc+lYs.........................................sps...........sts..ssLpuRTFGsWTlloullRhhsAhpl.pspslYplshhoahlALsHFhoEhlla+T.s.phs...hshh.....uPlhVuo.h.....................	0	46	89	137
+2446	PF04622	ERG2_Sigma1R		ERG2 and Sigma1 receptor like protein	Kerrison ND	anon	DOMO:DM04578;	Family	This family consists of the fungal C-8 sterol isomerase and mammalian sigma1 receptor. C-8 sterol isomerase (delta-8--delta-7 sterol isomerase), catalyses a  reaction in ergosterol biosynthesis, which results in unsaturation at C-7  in the B ring of sterols [1]. Sigma 1 receptor is a low molecular mass mammalian protein located in the  endoplasmic reticulum [2], which interacts with endogenous steroid  hormones, such as progesterone and testosterone [3].  It also binds the  sigma ligands, which are are a set of chemically unrelated drugs including haloperidol, pentazocine, and ditolylguanidine [2].   Sigma1 effectors are not well understood, but sigma1 agonists have been observed to affect NMDA  receptor function, the alpha-adrenergic system and opioid analgesia.	19.50	19.50	20.00	19.80	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.32	0.70	-5.08	7	288	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	227	0	183	275	0	190.10	36	84.41	CHANGED	thhtalslhlslluslh.slpphlhpo.YhFD.cplpcluppulu.as.....sscsllpclhDpLpsh.ss.hhh......ssppEWVFNNAGGAMGsMaIlHASloEYLIhFGTslGTEGHoGhHhADDYFsILpGpQhAassGsh-..uEVYssGssH+htpGps+QYpMP..tssaALEhApGWIPsML.FGhhDsLSSTlDh.TLahTshlTuR-MltsLhhsKF	...........................................................h.......hhhshh....l..h.....hl.......hh....p.....alFs.ppltpluppsh.u.........................stpthhpplhsc.Lpp.p.ass..hl.........................tpptpWlF.......sNA.....GG.h.M.GuMhlLHASloEYlllFGTulGTcG.HoGh.a.h....A-sahs.ILpGp.....ht..ah..sG..s..hc...sElahP.GsshhhtpGpspthphs..sssahlEYuRGh..IPshL.FuhsDoh.SThDh.TLahThhhhu+thhhpLh..h............................................	0	58	101	148
+2447	PF01222	ERG4_ERG24		Ergosterol biosynthesis ERG4/ERG24 family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.58	0.70	-5.94	5	987	2012-10-01 22:51:20	2003-04-07 12:59:11	12	14	331	0	568	1273	263	356.30	30	87.33	CHANGED	+ptcaEFGG.stGAlGIphGhP....lhplahsspucsstsphhhPcohslssLhstI+s.sphlass...h....s+plWTVFhhaaslQAVhYlhLPG+hscGlPLS..sGc+LsY+lNAhao...hllTlAllslLpssplFcLpalhDpFuplhosAIlFuFALoIaLYltSLhssch.hs......c.LAsGGsSGNlIYDFFhG+ELNPRlG......LDlKMFhElRPGhlsWllINLusll+QYcpYGpVoPuLlhVsls..QhLYlsDulhsEEuVLTTMDITaDGFGFMLuFGDluhVPFTYSpQThYLssH.PspluWss.hsluIhllLhsGYYIF+oANuQKNsFR...........T.PtpPpLph..LKaIpTusGopLLsoGWWuhARHINYhGDWlQSLuWuLsTGFs................................olLPYFYslYFhlLLlHRstRD-+KCK+KYGcDWEEYC++VPY.+IIPYla	.......................................................................................................................................................................................................................................................................php...s..h....h...hhh..hahhh...phh..h..h........h........h......l......P...........Gh...h...spGh.L..........sGp.pL.pYphN...u.h.u.............hhh.s...h...s...h......h.s................h..h....h...h...h.t.......h.h...........h.shlh-.pahtlhsss....hlhuh.h....luhhhYh..p.uhhh.t................................tt.oG..s.hl.YDaah.GtELNPR.l.s............hDhK...hF...h.....p....hR..u..h.h.hhh.l........l.....s......l.................uh..........hhc..p...........h...c..................h.....G............h..l...........o...............s.......s...h.................h.hh.hh...................phhY.lh.s.hhh.Ep...................hhlsoh.................D.lhh-taGFhLhahshshlPahYshpshYLs..............p......P....p....h.s.h......................................hhh.l........h.h.h.h.h..h.u.a.hla.c.s.uN.pQKsh...FR.........................t.P..p.....s..h..h..hh.........ph...h....t...o........t........p......G......s....p......LLs...s...GWW.......GhsR+.p.Y.hu..Dh.h......h..u...h.s......a.s.L..s.s...G...h..s............................................................................p....h...s..a...F.Y.......l..a...h...sh.l.L....h...H...R..t..h..R...D.p.t.+.C.t.pK.YG.p..s..WpcYpphV.a.hhlPhla.............................	0	174	294	458
+2448	PF00769	ERM		Ezrin/radixin/moesin family	Bateman A	anon	Pfam-B_851 (release 2.1)	Family	This family of proteins contain a band 4.1 domain (Pfam:PF00373), at their amino terminus.  This family represents the rest of these proteins.	30.00	30.00	30.00	30.00	29.80	29.70	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.00	0.70	-4.84	10	499	2009-09-10 21:10:39	2003-04-07 12:59:11	14	15	129	5	242	462	0	216.90	35	42.32	CHANGED	EchE+cppELcc+hpphEEchpcupccLpcppc+stcL-pctpptccptcpLcpcppchpctpc+LccpstsptcE+ccLttElsEhstclpplcpupp++EpEsschpp-lppupEcc-cs+pchhthhsss.....................s....l.ts.....................sssptct.ss-sst-tSp-L-......s-sphccps...EEcRlTtscKNE+lQcpLpsL+oELussRDEoK.coshDhlHpEN.lRtGcDKYKTLRpIRpGNTKpRVDpFEuM	....................................................................................................EphE+p+pEL.cRLhphcEpsp.pA.pc.tL...tcppcpA..Ltpctphsp-.EA..c...h...........Ltp.ct.....tpA..cpthpclpppuhcp...tcppcp.LttcltEh....p.tpl..ttlp-tpc+....+ccEsp......ph.p.p....chppAp-s.c+s+pcLhthhsts.......................................................s.s............l.ts.........................................st.p..p...........s.....-....s...t....t...t...h....St-hp...............................s-s...hpchs......Ec-Rls.h-Ks.c.+lpc.QL............ptLpoEltth+.cp+...cTt.DhlHsEN...h+.t.G.c..sKYpTL..+........p........l+pGsTKpRls.FEth................................................................................................................	0	56	75	146
+2449	PF04137	ERO1		Endoplasmic Reticulum Oxidoreductin 1 (ERO1)	Wood V, Finn RD	anon	Pfam-B_4729 (release 7.3);	Family	Members of this family are required for the formation of disulphide bonds in the ER [1,2].	21.60	21.60	36.10	24.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.55	0.70	-5.44	39	459	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	292	6	304	440	6	345.10	38	75.19	CHANGED	pplhshLppLsp.scaF+aaKVNLh.ppC.............PFWscs..shC.ss..ps.....................CsVpssscp-.lPt.............sa+h....phps.......ppspp..tt...............hppslss.......tt.pthtthc-...hsp..as..h-Dpss...pusYVDLltNPERaTGYsGts.utplWpuIYcENCF........................spss.p.................................................................s.......ClE++lFYRLISGlHuSIusHLstcY........l......ppcs............................WtsN................lphFhpRl......u.......paP-RlpNLYFsYtlllRAlsKlpsah...pph..ph....ou...sp..........tpDpcs.......+phlpsllsplps....hsth...FDE.....shhFpss..tuhpLKc-F+p+F+N.lSclMDCVsC-KCRLWGKLQTpGhGTALKILFp.ss..........ppt........hp...LpRsElVALlNshsRlSpSlptlc	.........................................................h.tlhPhlppLhp.psaF+aa+....l.sLh..+.C.............PF..W....s-p.....uhC.s...ps................................................CuV....p.ssppc.lP.................................................sh+h....sphpt..........tppspp.....tt.............................lppslsp..........tt.hthtthD-...tpp..aC....-Dpps...spspYVsLlhNPERaT.GYpGss.AhplWpu..IYcENC.F..............p.ts...................................................................ts.C..lEKRsFY+LISGLHuSIshHLstcY..............L.pps......................p..........WssN................lp.FhpRh......s......ptPcR.lpNLYFh.Yhl.LRAlsKhts..ah......pp.......ph..h.oG..s.s.................tpDtcs........+phlhp.llpphps....................hs.h...FDE..............sthF..tss...................pu.pLK.c-.F+t+F.+N....lS+IMDCVGC-.KCRLWGKLQ.stGhGTALKILFp.ct...................................pp.........hpLpRpElVALhNs...hs.RlSpSlptl..............................	0	109	169	247
+2450	PF03238	ESAG1		ESAG protein	Bateman A	anon	Pfam-B_3037 (release 6.5)	Family	Expression-site-associated gene (ESAG) proteins are thought  to be involved in VSG activation. This family includes ESAG 117A Swiss:P04477 as well as ESAG IM Swiss: Q26705.	20.20	20.20	20.20	23.00	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.47	0.70	-5.06	10	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	8	0	13	53	1	220.90	55	71.32	CHANGED	sM-scpcKLEKLISYGNpMGDLVAKsGGLFAEVNESVRAVRKEIPuALIKsNKYYTAIAEITRTVWDDVKAlth..s.ucscCp-QcFcGVtEhcspCGDpTCPLucs.VsEuALpKYKsGCLplsVhsGSVScChNLPRsNLY+SGAlsoSs-sLcW+-cp.t.uphFQLpL+VcsIFGPLIAsFAAGQPPSsLhEMMsNITSLpSRFNEVHuNFTSLLlssNlssNVssTcSTI	.....MctpcDKLEKLI.SaGNpMGDLVAKsGGLFAEVNESVRuVRKElPsALI+sNKYYTAIAEIsRTVWDDVcult....s..sctcCpspchcuVtEhcspCGspTCPLtcu.VsEuuL.pKYKsGCLplsV...s..Gp.Vsc.ChNLPRssLY+sGAVpsSscsLcWcpst...sthFpLpl+VppIFuPLIusFuuGpsPSsLh-MhsNITSL.S+FNEVHsNFTSLLlssslpssVssTsSTI...............	1	0	13	13
+2451	PF03433	EspA	ESPA; 	EspA-like secreted protein 	Finn RD	anon	Pfam-B_4100 (release 6.6)	Family	EspA is the prototypical member of this family. EspA, together with EspB, EspD and Tir are exported by a type III secretion system.  These proteins are essential for attaching and effacing lesion formation. EspA is a structural protein and a major component of a large, transiently expressed, filamentous surface organelle which forms a direct link between the bacterium and the host cell [1,2].	22.20	22.20	22.80	45.30	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.20	0.71	-4.86	7	296	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	247	1	18	151	0	172.00	48	96.44	CHANGED	hS....ssshtuusp.sssssSpshsss.hups-slp....husuhusLh.hhhhh...o-LupuKaspMpppuccu+suQcMANplDthIAclpcss-K.tp.cLPp-VlcYhpD..NGIpV....DGhp.hs....................................................................................ttLspG-LpsVKuAL-spuNpsoDhVsQuQLplQph.pohNsssohhsuhQoh.uch.pu	......................................................................pss..hs...ss..hutp-slp..N.hu.h.usLLhhhhhh...pslu.sKF.......h-hpcsuccupssQchuN.hDthIAcstpus..s.K.....sKtclPpDVIcYhpD..NsIhl....sGho..s.......................................................................................................GcLstGsLQsVKAAlsscANp.TslhspuQlpIQpMSppLNhlhothosl.Sh.hch.S.h....................	0	6	8	13
+2452	PF04806	EspF		EspF protein repeat	Mifsud W	anon	Pfam-B_3518 (release 7.6)	Repeat	The enteropathogenic Escherichia coli EspF secreted protein induces host cell apoptosis. Its proline-rich structure suggests that it may act by binding to SH3 domains or EVH1 domains of host cell signalling proteins [1]. 	20.20	20.20	21.30	20.20	17.50	20.10	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.40	0.72	-3.77	3	690	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	113	3	0	484	0	43.70	74	73.26	CHANGED	IQPARSMAEHIPPAPNWPAPoPPVQNEQSRPLPDVAQRLVQHLAEHG	..............IQPARsMAEHIPPAPNWPAPsPPV..Q...NE...QSRPLPDVAQRLhQHLAEHG.........	0	0	0	0
+2453	PF00756	Esterase		Putative esterase	Bateman A	anon	Pfam-B_476 (release 2.1) & Pfam-B_4968 (Release 7.5)	Family	This family contains Esterase D Swiss:P10768. However it is not clear if all members of the family have the same function.  This family is related to the Pfam:PF00135 family.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.57	0.70	-4.96	20	9472	2012-10-03 11:45:05	2003-04-07 12:59:11	15	87	3654	69	2036	9626	1891	233.50	17	73.54	CHANGED	Sssh.spchpltlaLP.t......ssspphPllYhLDG.......ssa.pphsstphhpphstctth..sh.lshPhGsps.....t.h...........ssptstsppap..salppELsshlcusasspsps.......pulsGpShGGhuALhhALc..aPcpFspluuhSsh..............................ss.Wu..........tpst..psDshhph.t.ssstsslplhlssGsp-s.ht..ph.sph.........hphhstsppht..hphpthsthsc.a......usHshth..WpspLssthhph	......................................................................................................................h.tpphph..t.lhhPss..............tsspth...Pl.l...a....h.....L....c..G.....................................ssh..........p......p....h....t.....h....t.....t....h....h...p.....p.....h.....t.....t.......p....h...t......h.........h.....h...h....l...s......h............s.......t....s.....s.ps.......................h...................................................h.......t......t..........t......s........h.....s.....t..p....at...........sa..l..t...p...E...L....h....s...h...l...c....p...p...a...s....s..sspt..............psl.s.Gt.ShGG..h..s.A...L.h..h...u.lp......p..P....s....t....F.s.......p...l....s..u..h..S..s.h....................................................................................................................................s..Wh....................................t........h........p.......s.....s..h.............h........................................t.....t...........p....t....h............l......h....l...s..........G.....t.......t.....-.........................................................................................h.....t...t.....t..t.h.............h..t.....h................h.........p.....h..........................................a.tth.......h.............................................................................................................................................................................................................................	0	630	1289	1731
+2454	PF01684	ET		ET module	Hutter H, Bateman A	anon	Hutter H	Family	This domain has no known function. It is found in several C. elegans proteins. The domain contains 8-10 conserved cysteines that probably form 4-5 disulphide bridges. By inspection of the conservation of cysteines it looks like cysteines 1,2,3,4,9 and 10 are always present and that sometimes the pair 5 and 8 or the pair 6 and 7 are missing. This suggests that cysteines 5/8 and 6/7 make disulphide bridges. 	21.80	21.80	28.50	29.40	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.89	0.72	-3.95	22	150	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	5	0	150	131	0	83.50	33	82.03	CHANGED	CYsGlass.sss...hssuuhphCpG..pCuSloht.shNG..pssolYsCsPsslCpsLslss......sCssl.ss.........louCCCs.sssC.sssss	CYsGlass..sss....hssuuhphCp.G..pCuSloh..shsG...pssolYsCsPsslCpsLslss......sCsslpss.........louCCCs.s-sChsss.s.......	0	42	61	150
+2455	PF00766	ETF_alpha		Electron transfer flavoprotein FAD-binding domain	Bateman A	anon	Pfam-B_853 (release 2.1) & Pfam-B_1321 (release 3.0)	Domain	This domain found at the C-terminus of electron transfer flavoprotein alpha chain and binds to FAD [1]. The fold consists of a five-stranded parallel beta sheet as the core of the domain, flanked by alternating helices.  A small part of this domain is donated by the beta chain [1].	21.00	21.00	22.40	23.80	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-9.80	0.72	-4.36	39	4727	2012-10-03 09:55:27	2003-04-07 12:59:11	14	26	2782	14	1280	3485	2076	85.60	48	26.01	CHANGED	ps-.lspAcllVuGGRGltu..tEsFc..llp-LAchL.GusVGuSRssV-..........sGWhss-+QVGQTGKoV+PcLYIAsGISGAIQHhuGMcsSc	.............................p.s-LspAclVVSG..G.RGluu..........t-s.ap...llcpLActL......G.A..s.l......GuSRssV.D..........sGa.hsp-.hQVGQ.T...G+h.V.s.PcLYlAlGISGAIQHlAGhpsSc..................	0	448	834	1086
+2456	PF01012	ETF	ETF_beta; 	Electron transfer flavoprotein domain	Bateman A	anon	Pfam-B_1321 (release 3.0)	Domain	This family includes the homologous domain shared between the alpha and beta subunits of the electron transfer flavoprotein [1].	24.20	24.20	24.40	24.40	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.97	0.71	-4.53	174	9173	2012-10-02 18:00:56	2003-04-07 12:59:11	16	30	2828	46	2509	6583	4289	156.00	22	53.86	CHANGED	sshlls-.p..s......ssplp.shshpslstAtplupt..........p..lssls.......hG.....s.spsspt.....hhs.hGsccllhlsssthsth...sstshutslsphlpp..........ss..lllhussshucs....lusplAstLshshlosss..tlph..pss.................hh..hpRshh...uGp.thsplphs.....tllTlcs..sshps	..........................................s.........t....phtls..hsh.pslptAh.pLtpt.............................p..ls.sl.s................hG.....s..tps......t.p..s.........shs......h............Gs-cslll..p......s..s..t..h.t.th...........s..shApslsshlcp.......................tt..hs....lllhG...ssuhscs................lustl.AthLs.....h..s..hssso....plph....s.s.sp..................................hs.hpRtl...uGh..thh..p..l...phs......sllTlp.sh.p...................................................	0	863	1630	2135
+2457	PF05187	ETF_QO	ETFD; 	Electron transfer flavoprotein-ubiquinone oxidoreductase	Wood V, Bateman A	anon	Pfam-B_2305 (release 7.7)	Family	Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The two redox centres in the protein, FAD and a [4Fe4S] cluster, are present in a 64-kDa monomer [1]. 	20.40	20.40	20.40	20.40	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.44	0.72	-4.06	73	1342	2012-10-03 08:56:42	2003-04-07 12:59:11	8	18	1195	4	515	1183	1543	109.60	47	19.70	CHANGED	GhhhGhshuul-p...lhp....Gps..PW.TL+.cppsDassLcsAscsp..IsYPKPD....GtLoFD+LSSValSsTNHEE-QPsHLpLc....DsslslshNLshYsuPppRYCPAGVYEhVcc-	................................................GhhhGhhhsGl-p......lht....Gph.Pa....T.....L+.c.p..........c..s............DttsLcs.As..p...s...p........I.....sY......P.K..P.......D....G.pLoFD+.LSSValSsTNHEE-QPsHLpLp..............Dss..lPls.h.NLs...hYs..uPppRY.CPAGVYEhVcp.t............................	1	157	287	409
+2458	PF00178	Ets		Ets-domain	Finn RD	anon	Prosite 	Domain	\N	21.50	21.50	21.50	21.50	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-9.92	0.72	-3.84	15	2375	2012-10-04 14:01:12	2003-04-07 12:59:11	17	22	255	41	1162	2070	0	80.40	50	21.09	CHANGED	plpLWQFLLcLLsD..psppchIpWss.csGEFKls..DP-cVARLWGp+KN.KPsMNY-KLSRALRYYYc+sIl+KV..pGcRasY+Fsss	.........................lpLWpFLL-LLpD....ps.stphIpWps.....c...........pGcFK..lh...Ds-c..............V.ARhW....Gt+Ks......+..P.s..M..N.Y.-KLSRAL......R............Y.Y.Yc....+s..Il..pK..l.....p.G...cRhsY+Fs..p.....................	1	249	337	689
+2459	PF03318	ETX_MTX2		Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2	Mifsud W	anon	Pfam-B_3569 (release 6.5)	Family	This family appears to be distantly related to Pfam:PF01117.	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.49	0.70	-4.80	15	164	2012-10-01 20:43:00	2003-04-07 12:59:11	8	8	81	12	52	305	3	208.90	14	66.88	CHANGED	sshsshsshhspshs........................h..t.sphhshsshasussslsNsTsppQphpThSFscshTcTsSsosTpGhp....huspssuphslsh.....ssEsslpho..lo..YNa...ooosTpTsososphhsPSQsVsVPP+spspsshhlt+sshs.sshpLhssl.up....................shho.hshscsshl.shttstssshsphssshs.hsssspl.phpGoGhhc.hstGsphhl+hschshssssutphs	.............................................................................................h...............................................p....shhhtpshhpN.s.ost.p.p.p.h.p..o...paspshs.po....s..ohosppGhp....huhpsshp..hslPh.....hsp..sshphs..hp....ash......spo...po...ps...so.pp.......p.ph.h..ss....sp...s...l..tVPspppspsphh.lpcsp...hp.ssh..p..h........sph.............................................................................................................................................................................t...................................................................................................	0	27	34	46
+2460	PF01459	Porin_3	Euk_porin; 	Eukaryotic porin	Bateman A	anon	Prodom_3211 (release 99.1) & Pfam-B__3211 (release 7.5)	Family	\N	26.90	26.90	26.90	27.30	26.50	26.80	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.59	0.70	-5.10	90	1317	2009-01-15 18:05:59	2003-04-07 12:59:11	17	7	369	3	757	1211	9	250.60	22	88.76	CHANGED	sPssap-luKcs.+Dlhs+s.a.hssh+hclssh..ssu.stFpsou.............stshtss.......................hsstslpspat.......shshs................................................................hphss.ssslssplplpcthstu..l+sphssphsssp......psupl..chpYppsphshssslsh..t......sshhsushlhuhs.slslGs-ssacsspsphsp.shuluas.sp..................................cahsuhpl.sp......ssshsuSaap+ls..splpsGs-hshshsss.................pssho..........lGspYplcpss..tl+u+lsssGhlushhpccL..psslplsluuplDsh+t........stKlG	.......................................................................................Pssap-ls+ps..+..Dlhsps....a....h.s..hh....+hslpp.....s.u..s.tFp.sst........................shphtst..........................................................hssh..slpspat................shshh.......................................................................................................................................................phss...s...sshssp..h.pl.p.pt.l.spu...L+.hph..ss....p...h......s...s.s.p..............................psspl.......chpYpt.pphshs.ssls...h...................ssh.hh..ss...hlh.u..hp...s..........hhhG.hphsa.cttp.sp..hsp........shs...luat..s....t....................................ca.hsh.pl.pp..............tsth.tuSh.a..p.....+.ls......pplpsuschsh..s.h.tsp.................p.s.p.hs...lu..spap..lctss..hh+....u..plsssuhluhhhpppl....t.s.l.pl..slu..u.lDthp...........shKhG....................................................................................	0	215	374	573
+2461	PF04346	EutH		Ethanolamine utilisation protein, EutH	Mifsud W	anon	COG3192	Family	EutH is a bacterial membrane protein whose molecular function is unknown. It has been suggested that it may act as an ethanolamine transporter, responsible for carrying ethanolamine from the periplasm to the cytoplasm [1].	25.00	25.00	28.10	28.10	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-11.99	0.70	-5.49	27	734	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	686	0	58	324	5	371.20	64	95.93	CHANGED	M..s.INcIIlYIhhlFhVlGAlDpl..................lGs+h.GLGccF-EGlhuMGsLAluMsGIhulAPlLuplLpsllsPlaphlGADPuhFAsTlLAsDMGGY.LAppLAp......s.cuhlauGlIlGuMhGsTIVFoIPVuLGlIcKcD+cYhApGlLsGllTIPlGshluGl.ls..............G......hshhhllpNLlPlllhulLlAlGLhhhPstMI+GFhhFGKhlsslIslGLshullptlTG....hslls............GhsPI...........pculpllGpIuIhLAGAFPhVhllT+hhpKPLttlGchLGhsssuAAGhlAoLANsIsMFthhK-MssRGKllNlAFuVsAAFlhGDHLGFoAuhpsshIhPhllGKLlGGlsAlhlAhhls	..........................Mu.INEIIMYIMMhFMLIuAVD+.I..................hGppl.G.GuQFEEGFMAMGALuLAMVGhsALAPVLA+VLGPVIlPVYEhLGAsPSMFAGTLLAsDMGGFhLAcELAu......DsuAWLaSGLILGSMMGPTIVFSIPVALGIIE.sDR+YLALGVLAGIVTIPIGCIAGGL.lAhhsth............sh..lp......FoFuLILhNhIPVlIVAlLlALGLKFI.PEKMIsGFQIFuKalVALITlGLAAAllcaLLG....acLIP.........GlDPIhhs.....t-.hRAIEVIGSIusVLhGAYPMVh.LLTRaFcKPLMsVGKlLsM.NslAAAGMVATLANNIPMFGMMKp.MDsRGKVINsAFAVSAAFsLGDHLGFsAus.h....s.uM.IFPMIVGKLlGGVTAIuVAhhL.s..................	0	29	41	51
+2462	PF03319	EutN_CcmL		Ethanolamine utilisation protein EutN/carboxysome	Mifsud W	anon	Pfam-B_3053 (release 6.5)	Family	The crystal structure of EutN contains a central five-stranded beta-barrel, with an alpha-helix at the open end of this barrel (PDB:2HD3). The structure also contains three additional beta-strands, which help the formation of a tight hexamer, with a hole in the center. this suggests that EutN forms a pore, with an opening of 26 Angstrom in diameter on one face and 14 Angstrom on the other face [2]. EutN is involved in the cobalamin-dependent degradation of ethanolamine [1].	25.00	25.00	27.80	27.40	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.57	0.72	-3.60	51	1340	2012-10-03 20:18:02	2003-04-07 12:59:11	8	3	931	33	216	583	325	82.50	46	89.31	CHANGED	Mhlu....+VlGslhuTpKsssLsGtKLLlVc.lc...........ptt.tuphhVAsDslGAGhG-hVLlsp.GSuARtshss.p.ssPl...DssIlGIlD	..........MpLAcVsGslVuTp+ppuLsspKLLlVchls...........................p.s.p..ssupstVAlD.slG.AGsGEhVLlss.GSoARpu.hps...p....stPl.....DhsllGIlD...................	0	95	156	191
+2463	PF02472	ExbD		Biopolymer transport protein ExbD/TolR	Mian N, Bateman A	anon	Pfam-B_2343 (release 5.4)	Family	This group of proteins are membrane bound transport proteins essential for ferric ion uptake in bacteria [1]. The Pfam family consists of ExbD, and TolR which are involved in TonB-dependent transport of various  receptor bound substrates including colicins [2].	25.40	25.40	25.40	25.90	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.75	0.71	-4.15	80	6991	2009-09-11 05:16:59	2003-04-07 12:59:11	11	4	2435	5	1847	4807	3274	131.40	24	90.36	CHANGED	cpp.tsplslsPhlDlhalLLlFFhl.oushsptt....h..plsL.Psssssp................hpppptlhlsls....tc.....sp......hh.......................................lssp...h...shppLtspLpphtpppsp..........................lllpuDpsssappllplhsthpps.Ghpplslssptp	..........................................p....hs-INlsPhlDVhLVLLlhFMl..Tushhsps.................l.....plsL...P.pus..sss.........................spspps.l..h.lsls............ss................sp....................lh............................................................................................................................................................lspp..........l............shpp.l.t.s.t.l..p...p...ht.pt..p.sps........................................................................hlhlp...uDcs.ssYpplhplhstlpp..u.Gh..p.plulhst..t....................................................................................	0	593	1191	1567
+2464	PF01541	GIY-YIG	Exci_endo_N; 	GIY-YIG catalytic domain	Bashton M, Bateman A	anon	Pfam-B_489 (release 4.0)	Domain	This domain called GIY-YIG is found in the amino terminal region of excinuclease abc subunit c (uvrC), bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage.  The structure of I-TevI a GIY-YIG endonuclease, reveals a novel alpha/beta-fold with a central three-stranded antiparallel beta-sheet flanked by three helices [4]. The most conserved and putative catalytic residues are located on a shallow, concave surface and include a metal coordination site.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.17	0.72	-3.61	105	9798	2012-10-01 19:55:08	2003-04-07 12:59:11	19	83	4836	20	2329	7330	3586	77.80	26	19.92	CHANGED	psslYhlh....st......ps...................phh....YlGpo.p..sl.ppRh.ppH..hps.......tptpht.................hpshphh.hlphhpspptt.........hphEpthlpthps.......thN	........................................................................................t.sulYhhp..........st........ss.....................................phl.....YlGpu...p........s...L...+p...Rl..psa.......hps..............p.s..s..p.t.ppt............................hpsh..phh....h.h..p..h...s..s......s....c.scA........................LhhEt.pll+hhps.....................................................................................	0	771	1529	1995
+2465	PF03081	Exo70		Exo70 exocyst complex subunit	Mifsud W	anon	Pfam-B_2462 (release 6.4)	Family	The Exo70 protein forms one subunit of the exocyst complex. First discovered in S. cerevisiae [1], Exo70 and other exocyst proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of exocytosis, and is localised at the tip of the bud, the major site of exocytosis in yeast [1]. Exo70 interacts with the Rho3 GTPase [4]. This interaction mediates one of the three known functions of Rho3 in cell polarity: vesicle docking and fusion with the plasma membrane (the other two functions are regulation of actin polarity and transport of exocytic vesicles from the mother cell to the bud) [3]. In humans, the functions of Exo70 and the exocyst complex are less well characterised: Exo70 is expressed in several tissues and is thought to also be involved in exocytosis [2].	23.70	23.70	24.30	23.80	23.30	23.60	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.07	0.70	-5.67	58	882	2012-10-03 17:31:52	2003-04-07 12:59:11	10	11	263	7	540	852	0	323.30	22	57.29	CHANGED	hppWlpshphshpslhtsEc.pLhspl................asst..s.......tppsFscls.ppslt.....pllphsctls...................pstpssp.tlhcll-hhpslpch...hsplpthhps.........t.hh...phpph..........hppLtcsspphht-hhstlpp.................psspphs.ssGulp.lTphlMsalphLs..-apssLspllts.ssss...................................sts.luphlspllssLhssL-t+....u+thp............................c.uL........ptlFLhNNhpalhpp..lcp............S...cLtslLGsphhpchp...pthcpahst...YhcssWspl.hshLps...........................................tths..........spppp.hK-+.............h+pFspuF--hhppQ.ppapl..sDspLRppL+psltphll...PsYppFhs+atstht.....t........al+as.s--..lcshlscL	..................................................................................................h.hh..shthlh.sEh.plhppl................................hst..t..............tttsFsphs..pssh.......tlhp.hscsls.......................hthpsst..plhpll.s.hhpslpph.................hsphpt.hhts......................................................htt...ph.th..................hppltpsst.thh..t...-h.ptlpp.................pstpshs.........s.GslH...lTp.s....hpalphLh..cappslttlh.tp.ttts........................................................................................................spp.luth....lhplltsLtts....L-sK.............u.+.h.Yc............................-.uL................pt.lFLhNNhpalhpp..lcp...............................................................................S......pLttl..l...u..p....p.hh.pphp....phh.cphhpt...Y.cs.Wtpl.hsh..Ltp........................................................t..t.........stpp...p..l.K.c+.................hctFNttF--hhptQ..ptWhl.....sD..pLRppl+.sltphlh...s.sYpt..Fhp+.atth........................t.t+al+.Ys.scplpphltp.....................................	0	109	289	425
+2466	PF04257	Exonuc_V_gamma		Exodeoxyribonuclease V, gamma subunit 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The Exodeoxyribonuclease V enzyme is a multi-subunit enzyme comprised of the proteins RecB, RecC (this family) and  RecD.  This enzyme plays an important role in homologous genetic recombination, repair of double strand DNA breaks resistance to UV irradiation and chemical DNA-damage. The enzyme (EC:3.1.11.5) catalyses ssDNA or dsDNA-dependent ATP hydrolysis, hydrolysis of ssDNA or dsDNA and unwinding of dsDNA [1]. This family consists of two AAA domains.	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	805	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.30	0.70	-13.43	0.70	-6.56	84	2140	2012-10-05 12:31:08	2003-04-07 12:59:11	9	6	1971	4	352	2371	649	635.20	26	61.91	CHANGED	MlplapSN+hEhLsphLsphlp...pPhsp.........Phps...EhllVpS.GhspWLphpLA............pptG..IuAslcF.shPusalhphhppl.lsp..ls...p....ps.s........FsppslsW+lhplL.....Pp......hh.........pp.st.atsLppYL.............sscsst...........h+haQLAp+lADlFDpYhlYR..............P-WlssWcpG.......................tthstspp.W...........QshLWRtL...hpchtttt.t...p..........hh.....hptlpp..tptt.ptLPc.RlhlFGlSsLsshhLclLpuLuph..t-VpLahhNPsppaWu..-lhs..p+phhp...................................t.tppthhttu......sPLLAuhG+.GR-ahphLtph.........................ttpch-hF...........ssppss...............LLpplQs-ILp..................tttptpht..hstsDpSlplHsCHSshREVElL+DpLLphh....spD....s.s......LpP+DIlVMsPDl-sYAPhIpAVF....u.................stptlPasl.uD...pshpppsslhtuhhpLLsL.spoRhsss-llsLLpsPsltp+Fslspp-lpplcpWlppuGlRWGlDtpp+pp...h..ths....s.pppoWphGLcRhLLGaAhs.................sssh..........hp....slhPa.splpG.puphlG+LhphlcpLpphhppL....pps.pshppWtphlppllsshF...sss.....scpphp...lptlpptlsph.tptsppus...............hpp..........lslsllpphLtppLsppsts..tFhsGsloFCslhPMRuIPF+VlCLLGhN-GsaPRpptssu.FDLhsp..p.....+.hGDRu+R--DRYLFLEALLSARcpLYlSYlGp.sh+DssphsPSlllsELl-alppsh..................stpshpph...h......hp.HsLpPFs.phF...................tssthhSas..ppahtstpthpptt.................................................tshhst.....................stst.pslsLpp	.............................................................................................................................................................................................................................................hhlh.upph-.L.thh...ht.......t..............sht....p...l.lV.u.uhtpaLp.tl..u.....................tt...G..lsAslt.h..hstthhhphh.th..h...........t................ps...............h...s..t.h.W.p..lht...ll............................t.........h.................................tp..........h..........lttaL.............................................t.....tt............................thaplutphAslFspY.hhR...............sphl.tWtts........................................h.....tt....W............Qs.LWp.tl...ht.h.t...t.......................................................h.....httl............t.t..thPt..p...lhlhuhsths...lphlttluph....hplhlhh.sPst..hWtsl.t........t.h.t...............................................................t........psL.LsthG+.sp-...hL.t.............................................tha.........................................................t...ts............hLtt..lQtslhp...................................................................................t.ptth...ls.tD.p.S.....lphasC..Hos.RElE.lLp-pLLthl....pps..............s..s........LpP+DllV..hs..sD...lssYsPhIpAlF..................u.....................spthlP..atl.uD...pp.stp..pp...Pl...lpshhsLLsL.......p......uRa.stp-llsLLcs...ss...l.t.t...+F...slsp.p....slphl......cpalptuGI...R........a..Ghsttphtt...................ths........t.ttpoWp.hu..l.....p...R..hlL....Ghuh.t....................tts...............h.t....s....hh.s........h...s.......t......tu.........hth.h.GpLsp.hl.....tLp........hhp...tl...........tp.......t.sh.t...p.W.h......h...h...p...p...h..l..p...thh.........s..............t.pttht..............ht.lpp....h...tth...htt...h.t.st.........................h..tt....................lsh.t.h.l.tp.....l.t..t..t..L......st.t.......thp....t..a.h..sG...lshsohhshRulPa+llslLGhs.-Gs.aP..c..p.................s.......s......h.......D......L....hst...t..................t....G.........D.R.........s.........pR...p...-...-R.hL............hL.-u......l..huApp...Lhlo..Yh.G..t..s..p..ss...p.....h......Pusl...lp...pL..h-.h...ltt.h...................................s..th..........h...Hsh.sFs.p..a.............................s.....sas..tphh.httt..tt............................................................hth......................................................................................................................................................................................................................................................................................	0	96	194	283
+2467	PF02601	Exonuc_VII_L	Exonuclease_VII; 	Exonuclease VII, large subunit	Bashton M, Bateman A	anon	COG1570	Family	This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5'  direction to yield 5'-phosphomononucleotides.  This exonuclease VII enzyme is composed of one large subunit and 4 small ones [1].	22.30	22.30	22.40	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.94	0.70	-5.24	27	4810	2009-09-16 18:18:13	2003-04-07 12:59:11	10	9	4139	0	1058	3717	1818	268.20	31	69.15	CHANGED	lFchs+KpslPthPp+IullTStouAuhpDhhcshpc..RhshsclhlhsshVQGcsAspplhpAlpph..s....th..hDslllsRGGGShpDLhsFNcpplsRslspss..lPVloGIGHEsDpTlsDhVADhRssTPTtA....Achllsctpcht...ppLpshppclppshppplcpppppLthhppphh..s........................................lpppppplpphtp+ltp......................shpphhpptppplpp...................................................................................................................................................LpppLcshsPpphLpRGaullh.pcG+llpsspcl.cpsctlplpht-Gphtspl	.......................................................................LFs.phKpslP..hscplGllTS..o..GAul..+Dllpslpc....RhP..hp.lllaPshVQGppAs...........t..pIspulphh...............s....t.......h......t.....................p.......hDllIluRGGGSlEDLW.sFN-.EhlsRAlhtsp...hP.llSuVGHE.sDh.TlsDaVADhRAsTPouA.............AEhs.s....s.s.t.t.-hh....pplpphpt+l...tpshpph..lp.ppppplpplppph.htp.....................................................................P.hh.......hpt.p.tp.p.lcph.p.p..c.lpt....................................................................shp.p.hlp...ptppphptht....................................h.......................................................h......................ht..................................................................................................................................................................................t.ttpht.h.ptLpsl.s.P..th....lt..RGY..u...ls.p...................p.....p.s......p....h.lppsppl...p.sptlphphtDG.lps.............................................................................................................................................................	0	371	715	913
+2468	PF02095	Extensin_1	Extensin; 	Extensin-like protein repeat	Mian N, Bateman A	anon	IPR002966	Repeat	\N	15.00	0.20	15.20	0.20	14.60	0.10	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.48	0.74	-5.49	0.74	-3.49	28	430	2009-09-16 13:20:14	2003-04-07 12:59:11	10	19	12	0	56	410	4	9.60	82	76.50	CHANGED	PPVYKPPVEK	.....PPVYKPPVEK....	0	0	56	56
+2469	PF01267	F-actin_cap_A		F-actin capping protein alpha subunit	Finn RD, Bateman A	anon	Prosite	Family	\N	22.30	22.30	37.40	26.90	21.60	20.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.93	0.70	-5.34	39	514	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	296	35	304	465	1	246.50	40	88.89	CHANGED	pptcl..ssphlpsAPPGEls-VhsDl+sl.hss..........t...lpss...ltsAhppYNpcphsslclss..ppsllop.ascl..........tss+YhDspspptFphDHlppcusshps......h....spph-.h.....p..psl.cpLp....tYspcaY.ssushsV.........................................................................................................................................ashpssst........................ltllIhup+asspNFasGcWRSpaphs......t...plpGplclplHYYEDGNVpLpssKshpp......sh...ss...t.ApsllptIpphEspappplscsaspls-ssF.KuLRRpLPlTRsKlsWs+.lssY+LGp-	.....................................hcIsspFlhpAPPGEh...s-Vhs.......Dl+hL.ls.s..........-.sllcps...hs..pAFtpYN.hcQh..sslc.l...pG...ppp........V...lIocascL....................................................usu+ahDPcs.phsFpaDHlcpcAo.Dsps...........hp.....stth-th................R.pulppsLp....sYlp-HY..ssGs...s.s..V.......................................................................................................................................................................................a.spp.csp................................plhssIpuppapspNFWNGRWRSp.Wphsh......ssss....plsGhl+lp.VHYYED.GNVpLsopK-lpp................ols...sss......t..psApphl+hlctsEscYQs....uls-sapshS-ssF.Ku.LRRQLPVTRoKl-WsK.lhuY+lGp-.........................................	0	82	132	212
+2470	PF00469	F-protein		Negative factor, (F-Protein) or Nef	Finn RD	anon	Pfam-B_128 (release 1.0)	Family	Nef protein accelerates virulent progression of AIDS by its interaction with cellular proteins involved in signal transduction and host cell activation. Nef has been shown to  bind specifically to a subset of the Src kinase family.	20.60	15.00	20.70	15.00	20.30	14.90	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.64	0.70	-4.97	20	19129	2009-09-11 11:41:56	2003-04-07 12:59:11	15	3	100	35	0	15393	0	175.30	58	97.39	CHANGED	GuuhSK+pspsh.slRERLh+s.ttssutp.....t....u.st.spttsS.shEtp.thhpucs................hpppNhD...l-up--.-cVG.hPVpPpVPLRsMTYKhAlDhSHFlKEKGGLEGlaYScRRpcILDLYl.+EpGIhPDWQNYTsGPGlRYPhsFGWhaKLVPV-spptsE....-sEspCLlHPuQppthDD..scGElLhW+FDspLAhcacAhphaPEpatc	.................................................................GGKWS.K.p.p.h...h..G.Wss.lRERh+Rs......psu.t...........................G.V.G............AsSRDL.E+.+....GA.l.T.oS.N................Tst.sN.u..-..C...A.W.L...E.......A......Q...E..-....E...E...VG.FPVRPQVPLRPMTYKu..AhDLS.HFLKEKGG.L.EGLla.Sp.+RQ-ILDL.WlY+TQGaFPDWQNYTP..GPGh..........RaPLTF.GWCaKLVP.V.-spclEc...scGEss.sLL.H.Ph......s..H.G.h-D..s..ctEVLhW+FDSpLAh+.H..hA+E.hHPEaap................................	1	0	0	0
+2471	PF03807	F420_oxidored		NADP oxidoreductase coenzyme F420-dependent	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.98	0.72	-3.56	56	6885	2012-10-10 17:06:42	2003-04-07 12:59:11	12	28	4452	62	2074	23061	11556	93.30	25	34.58	CHANGED	plull.GsGshGpulupthstsG.......pplhhusuRss-+httht.pphs............htsps.sst-Asp..tu-lllluV.hpth.plhppl........thhps+lllsssss	..................................................pIuhI...G.s...Gs...M.u....p..A...l...h....p...G..l....l.....p....s..u.................s.ppl.....h......s........s..t......s..........p...p...h........p....t....l...t....p.p.hG......................................h.p..s..s..s...........s...s......t..c.....s......s.p........pu.....D.....l.....l..l.......L...A.......V....K....P..p.....h....h......t...p...l.l...ppl............tth.t...p..s.p....l.llSlsAG....................................................................................................................................	0	639	1255	1704
+2472	PF01115	F_actin_cap_B		F-actin capping protein, beta subunit	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.80	25.50	21.20	22.80	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.57	0.70	-5.17	31	384	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	276	28	239	354	4	220.90	55	84.34	CHANGED	phDuAL..DLlRRLsPpplccNLsslhs.LsP............cLs-DLLSSVDpPL+lpp.sppos..+-YLtCDYNRDGDSYRSPWSNpYaPsls.................-ushPScpLRcLElpANcuFDhYR-LYYEG.Gl........SSVYLWDl-ct......................uFAGVVLlKKs............................................spphsGsWDSIHVhElpppspt...........sspY+LTSTVlLpLps............p..t.....suslsLSGsLTRQtEpshslsss.......ssHlsNlGphlE-hEsphRshLpplYFuKsKDIl	...................hDsALDLhRRLsPpplccNLssLlsL.sP.............sLsEDLLSSVDQPLclt+.DctsG........+DYLLCDYNRDGDSYRSPW.......SNcY-PPL-........................DGshPSt+LRKLElcANpAFD.YR-LY..aEG.GV.............SSVYLWDLDc.......................GFA.GVlLlKKs.........................................s.ss.up.p.pGsWDSIHVhE.lp..-+.up............su.c.YKLTSTVhL.hLpT.....................................sp..pu.....sGphs..LuGslTR.QhE.....pD.slsss...........................................ssHluNlG+hVEDMEsKhRshLp-lYFGKsKDlV..........................	0	89	133	198
+2473	PF01116	F_bP_aldolase		Fructose-bisphosphate aldolase class-II	Finn RD, Bateman A	anon	Prosite	Domain	\N	25.40	25.40	25.70	25.70	25.00	25.20	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.79	0.70	-5.31	188	7516	2012-10-03 05:58:16	2003-04-07 12:59:11	15	14	4376	71	1389	4343	1369	297.90	34	95.98	CHANGED	slsshpclLpcApcstYAlsAFNlsNhEhlpAllcAApctpSPlIlQhSpGsh.pah.................G.hthlsthscshAcph.s.......VP.VsLHLDHups......h-slhpAlct........GF.oSl.......MhDuS.......chs.hEENlphT+cllchA+ths..ls...VEuElGpl..G.....Gp..EDults...ptt...........pthhTsP--AtcFsccTGlDu.....LAsulGssHG..hYps.........pPp........Lshp..h...................................LpcIpptl........................sl.......P.LVLHGu..........SGlsp-.....................plpculphGlsKlNlsT-hphAaspul....................+chltpp.st............aDPRphltsuppuhpchlpcphc..hh.Goss+s	....................................h..sshpphlppApc..psY.Al.s..AFN..s..s..N..h..E..hhp...AllcuApc.h.c.u.P.V.I.l.ph..S.s..Gut..p.ah..................G.ht.h.h...t...p.h..l...psh.u..cp.h..s........lPV.slHhDHu..tp................h-shhpulct..............GF.oSl......MhDuS..................chs.h....-E....Nlphs+c...l....V-h....sHt....hG..........loVEuELGsl........G.......Gp...EDslsspt...............pthh.TsP--s.t.ch.lpcT...GlDu......LAsulGssHG..sYp...............pPp..............Lshp..h...................................Lcclpchl.............................sl....P.LV...lHGu.....................SG..lspc......................c.Ip.c.uI.p.h...G.Vs..KlNlsT-.h.phAhsp.ul...................................+chhtpp...st............................aD.P.Rp.a.l.tsuppAhpphlppt.hp...hGstsp............................................................................................	0	471	906	1182
+2474	PF03405	FA_desaturase_2		Fatty acid desaturase	Bateman A	anon	Bateman A	Family	\N	21.60	21.60	21.60	21.90	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.02	0.70	-5.67	11	926	2012-10-01 21:25:29	2003-04-07 12:59:11	9	3	348	37	263	879	84	289.00	38	89.32	CHANGED	PPcKhEIF+SLEuWAccN.lLshLKPVEKsWQPpDFLPDPsS..DuF...p-QV+ELRcRs+ELPD-YFVVLVGDMITEEALPTYQTMlNsLDGl+DETGAS.oPWAlWTRAWTAEENRHGDLLNKYLYLSGRVDM+pIEKTIQYLIGSGMDPtTENNPYL.......GFlYTSFQERATFISHGNTARLAK-aGDhpLAQICGoIAuDEKRHETAYTKIVEKLFElDPDsTlLAlADMM+KKIoMPAHLMYDGcDssLFcHFSAVAQRlGVYTA+DYsD.ILEaLVsRWcV-KlT.GLSuEGR+AQD....aVCuLssRIRRLEERAptRA+ptt...slPFSWIFsRcV	.............................................................phclhpp.L-..shs-pp.l.pa.Lp.scc.sWpPpDal.P.......spu.............csF........h..tsc-hc.ct...........ppls-shhlshVsshlTE-sLPo....Y....pp.lsp....h.....u.h...........s..G...u...............sWu.tW.sptWTAEENRHG.lLpc.YL.hl.ot.pVD.p.p.lEcsh.hllss...Ghc.s..t.p...p..s.sshh.................uhlYs.oFQEhAThlS.HtN.....Tu.....+h..u.............u.........D.hL.uplhupIAuDEpRHthhYppllcphh-l..sP.stshhAhschhpp.hpMP.u.t.hh.-.................................Fp.+huslhtchGVYssp.pa.h.-.llp.l.lpcWcl.p.ht..s....los-Gp....+Ap....-....alp....tLs...ph...p+h.....pE.ptp.t.hh.t...p......................................................................................................................................................	0	59	187	239
+2475	PF04116	FA_hydroxylase	Fatty_acid_hyrd; 	Fatty acid hydroxylase superfamily	Bateman A, Wood V, Finn RD	anon	Pfam-B_7847 (release 7.3) & DOMO:DM04600 & Pfam-B_905 (release 4.1);	Family	This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases.  Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways [1].  This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif.  Members of this family are integral membrane proteins.	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.55	0.71	-3.68	122	4549	2009-01-15 18:05:59	2003-04-07 12:59:11	8	43	1563	0	2248	4426	2057	115.30	21	37.33	CHANGED	hllhhlhh-hh.hYhhHR.hhH........hth...la...th..HthH.H...ps.......pt.phh....ssht...hps.hphlhhshhhh.................hhh...hh................hhh.hhhhhhhhhhtshhthhsHssh....................hhhh.....hhhthhhhssph..HphH.Ht	...................................................h.hhhhlhh-.hh.hYahHR.hhH......................hsh........la...ph.....H.p...s.H..H........p..........................pt..tsh.........suhh.........hps...hp...hhhh.shhhh........................hhs.....hhh.....................hs..h..t..s...h..s...h..h.hhhhh.hh.hht..hhsHssh................................hhh..............t.h..h.t.h...h...h.....s...s..sph......HchHH.........................................................	0	659	1293	1875
+2476	PF02504	FA_synthesis		Fatty acid synthesis protein	Mian N, Bateman A	anon	Pfam-B_1671 (release 5.4)	Family	The plsX gene is part of the bacterial fab gene cluster which encodes several key fatty acid biosynthetic enzymes [1]. The exact function of the plsX protein in fatty acid synthesis is unknown.	19.90	19.90	20.00	20.00	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.83	0.70	-5.56	11	3673	2012-10-02 21:08:39	2003-04-07 12:59:11	10	5	3469	4	781	2569	2334	315.60	40	93.65	CHANGED	h+lulDsMGGDauPh...pllcGllpAhpshs.lchhLlGsccthpshlpc.....cpsp.lpllpApshlpMc-sPstAlR+Kc.SSMtlulshl+cGcADuhlSAGNTGAlhuluhh+lutlpulsRPAlsshlPThs.G.hsllLDlGANV-scPccLlpFAlMGpsYupplh.shcsP.+lGLLNIGsEEpKGs-.....hh+psachL+sh....shsFlGNlEupDlhsGhsDVlVsDG......FsGNlhLKosEGssphltpll+-chcpshhutLtull...l..slKphtp+hDaspYsGuslhG.lstsVIKsHGsusupulhsAIctAtphlpsslsp+	....................................................................................plAlDsMGGDauPp...shl.ushp......A..lp..........p....h....s....p....l.c.llLhG..s.p....st.....l.....p...h..Lsp............................t....p.....+.....lp.....l.lps.s...-.h.Is.-.-..c..P..s.p.Al..RpK+.sS..S.......M...........hl...........AhchV...........K............c...........G....c....AcAsl..S..A..G..NTGALMuhuhhlltp.l.......c.G.......I.......-........R..P..A..LssslP.....o......h..............p....G....tslhLDlGAN..s-scsppLhQFAlMGuhaAcplh...slp.....pP..RVuLL...N...l...GpE.-sKGs-.....hh+cuhpLL...pp.t..........sl.NFlG.lEup-.lh.s..G....p...s.....D..VlVsDG......FsGNlsLKohEGsu....p.hl....h.p.hL.Kp.p....h....p.....s....u....h....h...u....K......l....u.u.ll........lp.ss.L..p...p...h...t...p.+hD.s.pYs..GAsL.L.G..LcGsVlKoHGuusscAhtsAI.c.pAhphlcppls..t.......................................	0	273	513	659
+2477	PF01557	FAA_hydrolase		Fumarylacetoacetate (FAA) hydrolase family	Bashton M, Bateman A	anon	Pfam-B_641 (release 4.0) & Pfam-B_1228 (release 4.1)	Family	This family consists of fumarylacetoacetate (FAA) hydrolase,  or fumarylacetoacetate hydrolase (FAH) and it also includes  HHDD isomerase/OPET decarboxylase from E. coli strain W.    FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses  fumarylacetoacetate into fumarate and acetoacetate which then join the  citric acid cycle [1]. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to  liver cirrhosis, hepatocellular carcinoma, renal tubular damages and  neurologic crises amongst other symptoms [1]. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites [3]. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerises this to OHED.  The final products of this pathway are pyruvic acid and succinic  semialdehyde. This family also includes various hydratases and 4-oxalocrotonate  decarboxylases which are involved in the bacterial meta-cleavage  pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli Swiss:P77608 is involved in the phenylpropionic acid pathway of E. coli and catalyses the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor [5]. OHED hydratase encoded by hpcG in E. coli Swiss:P42270 is involved  in the homoprotocatechuic acid (HPC) catabolism [6]. XylI in P. putida Swiss:P49155 is a 4-Oxalocrotonate decarboxylase [7].	23.90	23.90	23.90	23.90	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.56	0.70	-4.89	95	10787	2012-10-02 17:33:27	2003-04-07 12:59:11	13	37	3508	112	3559	8643	4023	213.40	24	76.20	CHANGED	p.lhshuhN........at.....p+sppht...........................................hshPh.....tsh....hah+sssulsu.....ss......................s.l..hhPtt.................tt.....lcaE.sELull....lG+..tspph.......ppA..hs.hlhGaslssDlo.s.......................Rch......phtth...........hhh.uKuh-shsslGPh.....lsshsphst....t.............................slplpspl.........................NGch..hpcu..ss.schlasstplluh.lSphh.................sLpsGDl....lhTGTs...t.s.......................................................................tsshhlpsGD...p.lpspl...............tt.........lGslp.s..pls	.................................................................................................lhshuhsat........sHstphs..................................s.t..........tsh........hFh+.s..s.s.....s......l....s..s......st.s............................s..l.....hhPpt....................................stp....hcaE.sELull...................lG+............sspph........s.pcA....hc...tlh..Ga.............s..ls.Dlo...t.........................R....ch..........Q.tptt..............shht..uKuhss.sss.l.G.....Ph.......lhs.hs.p.lss.........p.......................................s.lslphpl...........................................NGch..........hppu.....ss.....ss....h....las......h........s....p....l...l....u....a..l....ophh..................sLpsGDl....IhTGTs.......t..G.............t.................................................hlps.GD......p..lplph..............ps......lGp.lps.h.h...........................................	0	912	2048	2900
+2478	PF00667	FAD_binding_1	FAD_binding; 	FAD binding domain	Bateman A	anon	Pfam-B_180 (release 2.1)	Domain	This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.	21.80	21.80	21.80	21.80	21.40	21.70	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.45	0.70	-4.90	15	3726	2012-10-03 00:38:56	2003-04-07 12:59:11	15	73	2009	39	1475	3268	224	195.00	27	27.25	CHANGED	sPhctppsFhuslhss+cLpsssusRsshHlElDluso....ulpYpsGDHlGVaPsNspphVccllchlslss...cpslpLcsh-tp..........hc.Ph.sPsTlppALpaal-Iss.sPo+phLptLAsaAs-ts-+pcLchLuss...htpcapchthspshollclhccFPSschPhs.hLlsllPpLpPRYYSISSSschpPspVHlTssVVpacs....spG+h+pGVsSsa	..........................................................................................s.....ttsh.Aplhts.p.pl....s....s...........s...........u.....p...+..s.s.h..H.lEl....c...........l....s....ss..............slpYp.....sGD.t.luVhs.........pN.ss.....t.......hVppll...p..h..l..t...hss........cp.l..p......l..p.sts.............................................................................h..sltpsLphah-lss......s.stt...h.lpt.....hA......ph........s........s.....s...............p..p............................L..t..Lsss...............p.t...p..h.........p..p.a........h..............t...hs.h....l..........-.l.........l................p..............c...a..........s..........s.......s...............p........l............s.h..p...tllphL....Lp.P.RhYSIuS.............S....................t.........h.........t...........s.......s........c.............l.............c....lTVulVca.s........spup.....+..t...GssSsa.........................................................	0	471	808	1178
+2479	PF00890	FAD_binding_2		FAD binding domain	Bateman A	anon	Pfam-B_255 (release 3.0)	Family	This family includes members that bind FAD.  This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.32	0.70	-5.63	63	15429	2012-10-10 17:06:42	2003-04-07 12:59:11	19	132	4737	137	4045	50736	24820	363.40	25	69.86	CHANGED	DVlVlGuGhAGLsAAlphuc.pGh.plsllspstshtu..soshu.pGulshsh...t...t..DshchthpDshpus......sths.cpshsch.hsc.pusctlt.Lcph....Ghsasp........................t.......hhshpth.Gutptp...........................................cshh.sust.......sGpslltshhpps..hph.....lchh.chhstsLlh......p.......su....plpGshlt............psuphh....phtAp.uVllAsGGhut...................sht.ssss..sssGcGhshuhpsGst.lts..hchhtatPsulh....sssh.......hhpcshpu.G..........ulhls.spGcR..Fh.......................s-hsstchlscuhhtpchptsts..........sphaLhhsp.................................................lsscslcpplsthpcpstthhs.......hsshcc.............................P..............lhsss..hashGGltTDhpucs.............tttspslsGLaAsGpss...suuhcGssphuGsuL	...............................................................................................................................................................................................................DllllGuGh.AG..h....t....AA......l.........p........h.........s.......p.......t.......G..........h....p......l..h..l...l.s..+.....s...................h..tu...............po........h......h.....u......p........G.............G..........h............s...........s.........s....h.................................................................................................t.......D..........s.......h....p..........h...h......t......D......s.l..t.u.u..........................................shh..s.......c....p...p...h.....l....c....h........h.....s......p........p.......u.......s....p.....t....l...p......L..tph..................Gh...asp...................................................................................s...........................h....p...h...G..uh.php..................................................................................................................................R.h...h..h.....s..ss..h.................................s..G...p.......t.......l.....h....p......s......l......h......p.p..s.......h.p.ht.....................lph.h...t..ch..h..s...h.c.Llh....p.................cs...................................ps.h.Gshsh....................................................psu..phh............t.h.p.A..c...ulllAoG.G.hut...........................................................................h...h..t....h....s..o.......s....s..............h......s......o.G.c.G.h.s..h.uh.....cs.Gs...t...ht...s................h....-..h......h...Q....h.....a....P....s...s....h.......................ttth.......................................l.h...s..c..s.h..p..s..p...G...................................................u...h.h.....h......s...t.....p.....G...p..R...ah........................................................t-..h.....s.s..+...c......h....l....u.p..s....h..h........p....h.pttts.............................h.h..hL.hsp........................................................................................................................hs......p...h...l...t...p....p....h.....s..t..h........p.h.s.h......t..h......h..s............................h...s.....hpp.......................................................................h.......................................................l..h.P..ss............+a.....s.h.........G.....G.....l........s.s...p.s.ps.....................................................s....l....GLaA....sG.Ess.......suh..H..G..s.s..c..huusul..................................................................................................................................................................................................................................................................................................................................................................	1	1281	2555	3442
+2480	PF01494	FAD_binding_3		FAD binding domain	Bashton M, Bateman A	anon	Pfam-B_549 (release 4.0)	Family	This domain is involved in FAD binding in a number of enzymes.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.95	0.70	-5.40	20	17997	2012-10-10 17:06:42	2003-04-07 12:59:11	14	174	3547	120	7349	32963	12148	284.60	17	67.85	CHANGED	cssVL.IVGuGPsGLhhuthLuptGlc......shll-+hsssssts..RAtslppRTMElLcphGltcchtspusspphhutthtss.........................................................cttscl-....t.sussthsshsQsclE.lLhccApppG.splpauTE...lhuhppDtsGVsuhlp...sctsGpp....TlcucYllGsDGs+ShVRcslGlp.hcGptth..hshhslhhcu.sls.........hhhlhsscssGh.................hltPhps...t.hhhhsshs.phpst..ssphsp--stptlcshsussthss.chpthotashssphAccaRpG.RlFLAGDAAHhpPPsGGhGhNsulQDAaNLuWKLAtVLpGpAsssLLDoYssERpsluppllctu	..............................................................................................................................................................................................................plh.llGu.G...sGhh..........h.....A.............h.....h...L....t....p......t.........G...h.p...........................s.h.l......l......E............p..........t...................................................s................t........s..................s.........l...........t.................t.......s.....h..............p......h..........h..............p.......t...........h..........G.......l........h...p....t.....h............t........t...................h........h..h..................................................................................................................................................t..ht.............................................h....h.....h......h...................p.........t...............h.......t.......t.....h........L.....h................p.....t.....h............t...........s.......h..p...h..h....h..s......t..p.....................l......t....h................t........p........t.....p..........t...............t.........h.........h..........................t.t.........t..................................h...p........u......c........h...l.l.........uA.D.....G.........h........p......S....h....l.....R.........p.......h........h............s...........h......t.........h..........t..............t.............................................h.....h.......h.....h......t...h....h......h....t............h..........................................................h......h............t.t....h.................................................................hh.h.s..h........t.....................................................h................h.........................................................t...t..............................t.....h.........................t.........t..........h....................t.................h........................t............h..........h..............t.......................................................h.........................h.........t...................................................h............t...............h............h..............................h...........t.........................h.............h.........h...........t..........p..........h...............h.............t...............s......p.......l.......h...L..........h.G....D.............AAH...............s......h......Ph........t....G....p..........G....h....s.......huh......p...D....s...h.....L...s........h.....l...........t.................................................................................................................................................................t.........................................................................................................................................................................................................................................................................................................................	0	1974	4250	6144
+2481	PF00941	FAD_binding_5	dehydrog_molyb; 	FAD binding domain in molybdopterin dehydrogenase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1112 (release 3.0)	Family	\N	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.84	0.71	-4.82	94	4901	2012-10-02 01:00:47	2003-04-07 12:59:11	16	65	2185	108	1498	4277	1822	176.00	27	36.83	CHANGED	tphpahpPsolp-hhplht......ttssA+lluGuTslsshhchphhphshl.lslspl.s-Lptlpps..s....sslplGAssohsclhp..........tthsphhs.sLspthptlAu.QlRNhuTlGGNl.............................................ssusshuDhsssLhAlsAplpltssps..pR....plslp-.Fht.....shhpssL.pssEllhulplPhh	.................................................................................................t...pah+Psolpcs....lplhs...............tts..pA..c..l.l..AGG..Tslh...h....h+...h.....p........h....h....p...........s....h....l....lsl.s..p.l....EL...p.t.lp....hs...s....................sulcIGAssshs..cltpt..................................................hpp.t..h.......s...sLs...c..t.h....p..t.h.Au.h.Ql.R.Nhu.....TlGGNl.......................................................ssu.s.s......u....DhssshhAh..sApl......p...l.t....s....sp.....u......pR...........pl.s.lp-..Fat......................s.hcs..sL..ts.s.E...llhulhlP..........................................................................................................	1	466	867	1191
+2482	PF01687	Flavokinase	FAD_Synth; 	Riboflavin kinase	Bashton M, Bateman A, Mistry J, Eddy S	anon	Pfam-B_1221 (release 4.1)	Domain	This family represents the C-terminal region of the bifunctional riboflavin biosynthesis protein known as RibC in Bacillus subtilis.  The RibC protein from Bacillus subtilis has both flavokinase and flavin adenine dinucleotide synthetase (FAD-synthetase) activities. RibC plays an essential role in the flavin metabolism [1].  This domain is thought to have kinase activity [2].	19.60	19.60	20.60	20.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.59	0.71	-4.24	139	4738	2009-01-15 18:05:59	2003-04-07 12:59:11	12	21	4531	30	1203	3417	2167	126.90	37	41.33	CHANGED	hLG+saplpGpVl+Gpph.GRplGFPTANlph....pshllPtp...GVYsspspl...................................ssp..........................................................ha..ulsslGhpPT.hss....pph..plEsHlh................DF.st...-....lYGcplplpalphlRsEpKFs.ul-pLhpQIppDhptu+.phhs	.....................................................................hLG+saplp.GpVl+Gpph.G.Rp.............l.........G.............FPT..............ANltl...............pc.p.hhP.....tp...GVYAsp.l.p.l...............................................s.s.p................................................................................................................................ha....ulssl....G.....h.pPT..h.ss......tch............pl........E.....salh........................................DF...st......D.....l.Y.Gc.p.lpVtahchlRs.Et.K.Fs.u.......l.-tLhpQlppDtppA+phh.s................................	1	411	772	1021
+2483	PF04703	FaeA		FaeA-like protein	Mifsud W	anon	Pfam-B_5784 (release 7.5)	Family	This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase [1,2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.86	0.72	-3.81	5	310	2012-10-04 14:01:12	2003-04-07 12:59:11	7	14	259	2	35	393	13	62.30	35	44.62	CHANGED	MK-cILoalscl.........+uPC+TsEIA-AhGlSAYQARYYLhsLEKEGKI+RSPlRRGAuTLWclpu	..................................scIlpahpp..................pts..s+Tp.-IA-Ahul.o.h.Y.QARtYLhpLEctG..hV..c+..s.ht+Gh..t.h.W....s.................	0	6	14	21
+2484	PF02106	Fanconi_C	Fanconi; 	Fanconi anaemia group C protein	Mian N, Bateman A	anon	IPR000686	Family	\N	25.00	25.00	26.30	26.10	19.80	22.60	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.76	0.70	-6.07	5	88	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	36	0	35	71	0	385.40	44	98.24	CHANGED	MAQDSssLsoNaQFWMQKLSsWsQASTLETQ+DTCLHLuQFQEFLRQMYEsLKEMDSsA.lIERFPTIGQLLAKuCWNPFILAYDESQKILIWCLCCLhsKEPQNSsESKLNSWIRuLLSHlLSu.RFDh..KEVuLFspuLGYsshDYYPuLLKNMVLSLVSELRENHLNGhNoQcRMSPERVpSLSclCVPLlTLPDh-PLVEALLpYHG+EPQElLsPEFFEAVNEAFLpKKISLPsSAVlSLWhRHLPSLEsAsLHLLEKLlSScpNsLRRl-CaIKDSLLPQ.AACHPAIFRlVDEIFRsALLETDGAPEVlAsIQVFTpCFVEALcKENKQL+FALKTYFPYsuPuLlhsLLQ+Pp-IPpGHWLQsLKHIS-LL+ElVEDps+G..SausPFESWFLFVHFGGWlDlAAEQLLhu..AAEPP-ALLWLLAFYYuPpsGsQQRuQTMVElKsVlu+LhMLaRSssLSApDLQAuA.pssuuDsRsPssQQLVRHLLLNFLLWoPGGHoIApElIT+MAcTsAlp+EIIGFLDpTLYRhsHLulEusRocKLARELLcELpsQV	..........................php.WhpKh..Wtps...po.ps..Dss.HLs.hppFlpphhphlpphs......pph..htp..hLtp.C....hhu..tps.phlh...pL.sh.ptcP.sshp.ths.WhpslLsHllos.cht...tEss..hhpsLGYtshDYastLlcNhV.SLspELctsphsths.hp.pRhssp.phhslS.hClPLlTLs-htPLlEsLLhh..putpspEhLt.-Fh-tVs.......-Ahl.c+ls.....L.s.pulhsLWh+aLPSLEpAhLpLh-plhot.p.....pchpphlc-S.LPp.uAppsuIFhlVs-hF.R....sLhEo-Gs.plhshlQlFTpChlpthppps+Q.pasL+saFP.s..sLshsL.hppPp.tlspth..hhp.L.pIophL+phsE-tptt...............u.ts.aEtWFLhlphGtWschssp.Llh......tutss.tsLLWLLsFhatPpsttppRtpphsphp.hhs+Lhhh.t..p.shshtcLptsh......t.t.p.sh..tpLhh+Llhphhlas.tsh.hs.-hlshhh.ptth.pchh.hl.ph...h.h.p...p.t.cs.t...hhppL.tpL...............................	0	5	6	11
+2485	PF03511	Fanconi_A	Fanconia; 	Fanconi anaemia group A protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.90	20.90	21.00	32.30	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.13	0.72	-4.19	2	47	2009-12-01 10:28:13	2003-04-07 12:59:11	9	1	30	0	22	44	0	61.90	56	5.08	CHANGED	REELLlhLFFFSLMGLLSSaLTppsTs-h.KAhclCAtlLpCLE+RKlSWLsLFQLTEpDh+LG	.....EcLLV.LFFFSLMGLLSS+Lssps...ssD..KAl.clCApILpCLE+RKI.SWLsLFQLTEsDh.........	0	1	2	7
+2486	PF01149	Fapy_DNA_glyco		Formamidopyrimidine-DNA glycosylase N-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the N-terminal domain contains eight beta-strands, forming a beta-sandwich with two alpha-helices parallel to its edges [1].	24.40	24.40	24.60	24.50	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.78	0.71	-3.73	109	5183	2009-01-15 18:05:59	2003-04-07 12:59:11	19	13	3625	70	1224	3585	2246	118.40	30	42.40	CHANGED	PELPEVEslpcsL...pp.tlhGppItp.lplt..........psp.lchs.stt......htptlpGpplp.slpRRGKaLlhph......................................................................................ss.........sh.....hLlh..HLuMoGphhh......................................................................................ttt...t+Hs+lh..hph........s.sst.......................pLtasDsR+FGphp	..........................................PELPEVEs....sp+sl......ps...h....lhG...pp..l.p.p.l..t.lp......................s.p..l+h.s.stt..........h.tpLsGpplp.slp...RRGKaLlhch...............................................................................................ps...................st.......slls..HLu..M.sGphpl...............................................................................hstp..s.sp+H.s+..lt...hth............s..ssp.....................................hLh.atD.RpFGth.h.........................................................................................	0	373	766	1025
+2487	PF04750	Far-17a_AIG1		FAR-17a/AIG1-like protein	Mifsud W	anon	Pfam-B_3664 (release 7.5)	Family	This family includes the hamster androgen-induced FAR-17a protein (Swiss:Q60534) [1],  and its human homologue, the AIG1 protein (Swiss:Q9NVV5) [2]. The function of these proteins is unknown. This family also includes homologous regions from a number of other metazoan proteins.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.34	0.71	-5.15	28	524	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	287	0	312	511	38	182.70	21	80.16	CHANGED	hpllhHl............................................hsls.ashhhahhpp.sp.............taG..........G+apaLThlsL...................llpslaaslsllsDl...........pppcpLptl.....tDahhsshuFPlulhVslhFWsLah....hDccLlh.......Pchlsph................lP..hW.............LNHshHThshlhlll-hhhpp+paPp+ht...ulshhsshshuYhhW.lphlhthsG.hWlYPlhstluh.t+llhFshusllhhhhYlhuchLss	.............................................................................................h..............................................................................................hu...........tpa.paLThlsh....................h.hphhhhhlshltph.......................t..t.hhth........c.hhhshs...hsl....thh.......ls.hh.....aWs.lhh.......hs.phlh.......schhc...h................hP..ha.............l.s.hshHshshlhh.ll-hh..h.........t..h.s.....pht..............uhshh....s...s..hshhYhha...lh....h...h..h.............h...s....u....h........asYPhl.p.....hh.s...h......t..p..hh...h..ashshhhhhhhhhhh.....................................................	0	107	159	243
+2488	PF01581	FARP		FMRFamide related peptide family	Bateman A	anon	Pfam-B_666 (release 4.1)	Family	The neuroactive peptide Phe-Met-Arg-Phe-NH2 (FMRF-amide) has a variety of effects on both mammalian and invertebrate tissues [1].	15.00	2.30	15.00	2.30	14.90	2.20	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.70	0.77	-6.28	0.77	-2.59	61	1303	2009-11-03 19:08:40	2003-04-07 12:59:11	11	24	73	0	591	1475	4	10.20	46	34.60	CHANGED	ppcptahRFGR	......t..ptpahRFG+	0	210	278	550
+2489	PF02469	Fasciclin		Fasciclin domain	Bateman A	anon	Pfam-B_562 (release 5.4)	Family	This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.82	0.71	-4.13	122	4881	2009-09-10 22:24:17	2003-04-07 12:59:11	17	137	999	8	2602	4995	1077	128.40	22	47.97	CHANGED	sp...hoshhshlp.....su..sLs.ppL.................ss.s.........shTlFA.PoscAF.........tpl.....stsphptLht....spppLpplLpaHllss.ph..tsssltsh......................tp...............lpo..lpGs......plplshp.........ss.........plplss.......Apls..psDl.tssN.....GllHsIDpVL.lP	..........................................................s..hsphh.th.lp.......ts....sLs....ptL....................................................ssts............................shTl.FA....Po............s.pA.F...............................pp.l........................st..t...t.h.p..tlht...............spptlpp.lL........p....a..H...l..l.....ss...th....hss.s..l.tss..................................................................tp...................................................................................lpT......hp..Gp.............plplshp...............ss..........................................plhlss..................upl.h......p.s..s.l.....s..sN...................G..l...l..Hhl.D.p.VL.hP......................................................................................................................	0	870	1506	2063
+2490	PF02259	FAT		FAT domain	Sonnhammer ELL	anon	(Keith and Schreiber, Science 270:50)	Family	The FAT domain is named after FRAP, ATM and TRRAP.	20.00	20.00	20.00	20.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.01	0.70	-5.47	55	1294	2012-10-11 20:00:59	2003-04-07 12:59:11	18	84	321	0	880	1335	63	334.40	17	12.77	CHANGED	usLussAAWtlsp.W-p..hcphlsshp.........................pss.........cpp...FapAlLul..++sphc...cApphIcpuRpllssElou...LsscSYscuYshllplQ.........hLsELEEhlpap.phspt........spchctl....hpsWppRL.ss.pcsl-lWpcllphRsllls.............................................................sc-shphhl+FApLsRKssphslAp+sLppLht.t............................Pplhhs.h+h.Wtps.......pp...........pcAlppL.pchsp.phspsht.t.tp.ht.t...............................p..s.pp.htt.spLhA..+sahchGpaptpl..............p.ht.pshspllpuYttAsphcpphhK.AWcsWAhhNhcllph.tpt.t...................................................................hhpasssAlpsah+SluLups.....puhpchhRLLo	..............................................................................................................hhhtsuWthsp..Wpt......hp.p..h.lp...h..........................................................................................................................pps..........................cht..hhpuhhul........+ppphp.............................phpph..l.ppu..p...phh......hp.......phss.......hs..tp...s..h..p.pth.s..hlh..phQ...............hLsELc....-hhp.h..h.t...................................................pphptl...............hp.tW.pp..R...L............sh..tsshphh.....ppll...thRphhhp.........................................................................................................................................................p..p..h..p.h...h.l...ch...upl...sRKp.s..ph.p...l.uhptLh.p....lhp.................................................................................................spl...ht.hph.at....t....p...................................................pcAh...phL...p......p...h.p..hhppt..............h.......................................................................................................................................................t.......t....ttphh.u....csa...h..hhupahtph.........................................................pp.pthhp.tap.....t..u..s.ph...p.p..hh.............+...u..........at....t.hu..hh....t.p.hhpt.p.........................................................................................................................................................hphhh..ulpsahculth..spp........tshp.h.RlL...................................................................................................................................................................	0	319	487	724
+2491	PF02260	FATC		FATC domain	Sonnhammer ELL, Wood V, Mistry J	anon	(Keith and Schreiber, Science 270:50)	Family	The FATC domain is named after FRAP, ATM, TRRAP C-terminal [1]. The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability [2].	25.20	25.20	25.30	25.30	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.33	0.72	-4.51	141	1318	2009-01-15 18:05:59	2003-04-07 12:59:11	15	61	309	3	915	1361	13	32.60	39	1.32	CHANGED	p.sL.olptQVppLIppATsspNLuphYh.GWsPaa	.......h.sL.sVpsQ.VppLIppATs.cNL.....sphYh.GWssah....	0	330	502	761
+2492	PF00316	FBPase		Fructose-1-6-bisphosphatase	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.09	0.70	-5.61	12	2715	2012-10-02 15:53:20	2003-04-07 12:59:11	15	11	2198	197	881	2125	479	306.40	43	94.95	CHANGED	hTLsphhlppt......usu-.....lstllsulshus+hIuptlp+AuLsp.lGtuuusNspGDtQKtLDVluc-lhhsALcuS.sltshsSEEp--hlsh....stpupasVshDPLDGSSNIDsslSVGTIFuIa................sssssp..shhpsGp-.VAAGYslYGspThLVlohGs..GVptFsLD.s.GpFhLscpsh+lPtcuphauINpuNhpaas.slccaIcchhtstcssp.+sashRYlGShVADsHRhLl+G.GlFlYPust+...spGKLRlLYEstPhAFLhEQAGGtAosG+.cpl..LDlsPpplHpRsslhhGStscVt+hpchhtt.	........................................................................t.TLspal.hp...pptph....ssu-...............Ls.tLl.sslthusKhIsptl...p...+...u..........uL.......s.....s..l..l....G.......t...............u........G...........s........p.....N.l...Q.G...E..s.QpKL..Dlhu...N-...hhhsuLc..sp..s..tlsulA........SEEp..........-..........ch..ls..h.............t..t.....s....p........p.......u...c.YlVhhDPLDGSSNIDl..Nl.S.V.GT.I.FSIa+t.s..........................ssps..spt....ch.L..Q.....PGp.pQVAA.GYslYGsuTh..LVhT..sGs............G....V...p.........s..F..T.....h..........D.....s..s....l.......G............pFh.L..scp.........s..h..+..........l...Pc.c..G..p.........hYulNpGNhhpa.s....s.s.l+cYlc.hpttp..............pust....+sYshRYlG....S.............hVADh.HRsLl+.G.GIahYPustp.........psp..G..KLRL.LYEsNPMAFlhEQAGGt..........Ao...s.....G....p.....pRI...L.Dl...P.p.plHQRsshalGSpppVcclppaht.t.........................................................	0	253	520	722
+2493	PF03320	FBPase_glpX		Bacterial fructose-1,6-bisphosphatase, glpX-encoded	Mifsud W	anon	Pfam-B_3515 (release 6.5)	Family	\N	20.50	20.50	20.60	20.90	19.50	20.30	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.81	0.70	-5.79	111	2306	2012-10-02 15:53:20	2003-04-07 12:59:11	8	3	1790	13	437	1381	1900	308.20	54	95.06	CHANGED	-RsL...ulEllRVTEAAAlAuu+ahGRGDKpsADpAAV-AMRphlsplshcGsVV....IGEGEhDEAPM.LYIGEcVG.s..G..pGPp............lDIAVDPlEGTslsApGhsNAlAVlAhuc+GslLcAPDh.YM-KlAVGP........tucGhlD..lstslp-Nl+slAcAhs.+slp-lTVslLDRPRHpclIcclRpsGARl+LIsDGDVAuulssshsc.o..GlDlhhGIGGAPEGVluAAAl+ClGGphQuRLhs.............ps-pEc.pRspch..Gl...Dh..s+lhsh-DLVpupclhFuATGlTcGsLLcGV+a.....psst.spTcSlV.hRucoGTl.RhIcut..H	.......................RpLAhEhsRVTEuAALAuh+WhGRGDKNsADGAAVsAMRphLNplshcGplV......IGEGE.....hDE..APM.LY.IGEcVGsG......pGs.t................VDIAVDPlEGTphsAhGps.NALAVlAhu-+.....G.....shLc.A.PDM..YM-KLsVGP........tAtG.s..ID........LshPls-NL+sVAcAhu..Ksls-LsVslLc+PRHstlIpEhpphGsRVhhIsDGDVAuuIhTshs-...o.slDlhhGIGGAPEGVl.oAAAl+sLGG-MQuRLls..............h.s-pEhtR.CcpM..Gl......-.ss+VLpl-Dhs+u-..sllFuATGlTsG-LLcGlph.....push.....upTcoLl..hR.u+opTlRhIcohH..........................	0	146	291	369
+2494	PF02634	FdhD-NarQ		FdhD/NarQ family	Mian N, Bateman A, Iyer LM, Zhang D, Aravind, L	anon	COG1526	Family	A pan-bacterial lineage of proteins. Nitrate assimilation protein,  NarQ, [1] and FdhD (Swiss:P32177) are required for formate  dehydrogenase activity. Structurally, they possess a deaminase fold with a characteristic binding pocket, suggesting that they  might bind a nucleotide or related molecule allosterically to  regulate the formate dehydrogenase catalytic subunit [2].	25.00	25.00	27.50	25.80	22.70	24.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.49	0.70	-4.91	203	2755	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	2387	4	651	1935	1212	230.20	33	86.35	CHANGED	spEtPlslhl.NG........pphsshMsoP......................sch--hAlGFLhsEGllp.ssp-l..pulpls.....................................pp............t.p..........................lt...lp.........spt...t..h...cc+h..h..sssoGC........Gh..Ght..h.ph...hpth.h.........s.thplsssplhphhpplpp.tpslappTGulHuAulh..s.....ss..p..llhhtEDVGRHNAlDKlhGthhh.........psh.................s................hs...st.....hllsoGRlSsEMV.KsAphGlPlllohSAsTshAlclAcchGlTLlGhsRs..............pc..hslYot.scRlh	...................................................................................spEhPlslh.h....NG..........h.phsshMsoP......................pclE.phslGF.hoEGlIp.s.c-l...h.ulcls.......................................................ts.sss.........................lcls.........spt......thpt..........pc+th..sspouC...Gh..s..Ghpt..lpph.................hpshp.h................s.sh.phs.hs.p.l.hphhppL.pp....t.pt.lh.pp.TGulHuAAhhs.............ss..p....llsh+EDlGRHNALDKLlGtth.p.....p..s.h..............................s.......hpps..........hll.sSuRhShEhVtKuAhhGlslLhuhSAsTsLAlclAcchs.......lTLlGFs.Rs................sp..hslYotspRl.h.........................................................	0	188	402	541
+2495	PF04216	FdhE		Protein involved in formate dehydrogenase formation	Mifsud W	anon	COG3058	Family	The function of these proteins is unknown. They may possibly be involved in the formation of formate dehydrogenase.	27.20	27.20	28.30	27.90	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.25	0.70	-4.69	49	958	2009-09-11 05:40:51	2003-04-07 12:59:11	7	2	907	2	192	561	21	287.00	48	95.45	CHANGED	L....t.l........t..t.s.lhhss.tslatpR.....ApRLptLApp.pP.hu-YLpahAplscs.Qppl...lpph.shshs.st.h.t......tpuhPsLstpsh.p-stapt..hLptLlsplpst...s.ssshht..slctLcp...ssssplcthussLLs..........tphstsss..shshFlhAALplhasphAst..lstpshst.spp....shCPlCGohPluSllphssp.p.......Gh.RYLpCuLCpoEW+hlRscCssCspocslphhsl............-stps....sl+AEoCssCpuYlKhlh.p-ccsph-sh.ADDLAoLtLDlhh.p-pGapRsuhNPhLh	.............................................................................................................chssscpps...ushIPPLLFPphKslYsRR.....AcR.LRcLA-s...N.........P..LuDYL+FAAhIAcA.Qcsl.....Lh-a...PLp.h.-.ls.s.cl.tcs............pspG.p...PPLDhcs.l.s.R.D..p+.W.pc....LLhuLlAEL+Pc.................hssssLA.......lIEsLEK..............ASspELEshAs.ALhA...........................u-FusVuS......-K.APFIWAAL.S.LYWA....Q..hAsh......IPu+.....A....+..s..........E..aG.....Ep.R....................p.aCPVCGShPVuShVplGss...Q.........G..L.RYLHCsLCETEW.HlV.R.l.K..CSNCEQo.tcLcYWS.L.....................-.sEpA........AlKAESCsDCs.TYLKILY...QE..K...-.....P....c..V.........E.uV.....ADDLASLsLDucM.EpEG.aARSSlNPFLF.................................	0	56	112	156
+2496	PF03147	FDX-ACB		Ferredoxin-fold anticodon binding domain	Bateman A	anon	[1]	Domain	This is the anticodon binding domain found in some phenylalanyl tRNA synthetases.  The domain has a ferredoxin fold [1,2].	21.00	21.00	21.20	21.90	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.85	0.72	-3.81	134	4662	2009-09-10 22:44:18	2003-04-07 12:59:11	9	19	4522	20	1190	3729	2172	94.00	33	12.29	CHANGED	S+aPslpR.DlAlllsp..................sl.sss....plh..pslcpss......sp.hLc.slplFDlYp.G..........ppls.p..scKSlAhplhapst-+TLs-p-lsshhppllptLppchsupLR	........................S+FPuspR.DlAllVs.c........................................................s.l..sss......-lh........psl..cps.u.....................sp.....hLp.....slpLFDV..Yp..G...............cp.ls..p..........GcKSlAhsls.hp..s....s.-+TLs--E.....lstshpcllpsLpcchsApLR.....................	0	404	755	1004
+2497	PF00465	Fe-ADH		Iron-containing alcohol dehydrogenase 	Finn RD	anon	Prosite	Family	\N	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.24	0.70	-5.82	226	13485	2012-10-02 14:41:14	2003-04-07 12:59:11	14	23	3785	67	2682	11831	4421	355.90	25	79.39	CHANGED	P..s.c..lhhG...tG.s.lpplsp..hltph..t........+sLlVo...st.sh..tpt......u.hhcplhp...L..ppsulph.thast.l.pspPshpplpcuhp..hh+......pp..ss.......DsllulGGGSslDsAKuluhhhs.......................................lP............llslPTTuGTGSEso........shuVls..st...ppp..hKh.slts..phhP.......phullDPpLshshPhplsusouhDALsHslEuahs.....................p..ss............s..................hoD...............shuhpulc...hlhptL.ps.hpss.ps.....hpA.Rpph..hhuuhh....A....Ghuh....s...s..uuluh.......sHuluaslu....u.ha.p..............lsHGhssAlh.LPtlh..pash......................tp..htplup...hh.......................sp..............phlptlp....ph..hppl.ulPs.p...Lp-...h.G...ls..p....pp....l....spluptuhps..t..h.s....sPtthstp-.l	..................................................................................................................PtphhhG.tG.u...l.t.p.ls.p......htph....u..........+sllls...ct..slh..p..h...............G...hhsp.lhp....hL..........p..tts....l..p....h.....tla.....s.....t...l....p.s...s......P......o......h.....p.....s......l...p.....c......uh...p......h...h...p.......pt.......p.s...........D...h...l..l.u...lG...GGSs.hD.sAKu.............luhhhp......s.....t............th..............................hP.........................hls.lPT..T..u..G..T..GSEsT.....shuVIo..sp......................psp....hKh..slhs......ph..hP.......s.hullDs....pl.hh.shPtplsA....ssuh..........D..........A..........L..........s.......H.......s....l.......E.u...Y.so.......................ht......uss..............................h.o.D..................sh.u...h..p...ul.c........hl..h.c......t...l.......p....u........l.....p......ss........p....s..................ht..u.....R.....p.....p.....h.....hh.....u.......u.....h.h.......A........G.....h.u.F.....s.......s.......usl.uh................sHuh.u.H..tlu.............uha...c..................................................................ls..HG..hs.sAll....LP..tlh.paNt..............................................s......t+....htph.Ap....hh....................................th..........t.p.t.ttsp....................thlp.tlp............ph...h.p.pl....Gl...Pt..s........Lp-............h...G......lp....c........................pc....l....st....l.uptAhpc.ts....hhs....sPh...s.t.............................................................................................................................................................................................................	0	880	1660	2200
+2498	PF02742	Fe_dep_repr_C		Iron dependent repressor, metal binding and dimerisation domain	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family includes the Diphtheria toxin repressor.	20.70	20.70	21.00	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.08	0.72	-4.29	141	3389	2012-10-04 14:01:12	2003-04-07 12:59:11	10	16	2647	96	811	2165	650	67.10	34	34.92	CHANGED	TcpGcchAhpllR+HRLhEpFLschLuh.sh-clH--AcplEHhlS-chhc+lsphL..shPppsPHGsPI.Pst	.......TpcGcclApplhc+H+l.l.EpFLhphLGl.s.-ps+c-AEtlEHtlS-chlc+lpphl...p.....p.sP........t................	0	307	589	730
+2499	PF01325	Fe_dep_repress		Iron dependent repressor, N-terminal DNA binding domain	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.40	0.72	-4.03	10	3362	2012-10-04 14:01:12	2003-04-07 12:59:11	14	14	2588	94	779	4553	836	59.00	31	32.07	CHANGED	cLscstE-YLcsIYsLpE.spshspssclAEcLsVpPuoVocMlp+Lc+pGYVcYpsY+Gl	....................................shEDYLc.s...I.h..c.L........t.....p.....c....t......s....t....sp...s...s..clApcLsV.S.s.PoVoc.M...lp+L..pcpG..llphp.apu..................	0	286	561	700
+2500	PF02906	Fe_hyd_lg_C		Iron only hydrogenase large subunit, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.14	0.70	-5.15	141	3059	2009-01-15 18:05:59	2003-04-07 12:59:11	9	160	948	10	841	2861	59	227.10	30	56.42	CHANGED	+hVlsplAPAlRsulG-phuh..st...sG+hhuAL+c.LGFc.pVaDssauADlTlhEEusEhlc.Rl.........pp.st.......h..PhhTS.CCPuWlpasE+haP-.llsplSos+SP.thhGsllKs....hhsp......................th......s.spchhsVuIMPCsAKKhEut.R.-hps.......................cVDhVLTocELuphl+............pt.....sIc.hspLtc...pphDts.h.......s...uouuGtl............F.........GsoGGVhEAslRsshchh.........t..ppht.......hph..hRsh.t.....sh+.sphpl..............................................s........l.+lulspGl..t.ssccllcpl..+s.................G.....................c.....tp.......acFlElMACPGGClsGGG..QP	.............................................................................................h..sst....ht..........................................t..hh...t....hh............h...........t...h..........G......ht.............h.h.-.sshst.phsh....tp.Ehhp.+h..................................................pp...tt.................shhoS.sCP...u..alphhEph...........a.P................c...hls.plSs..s+SP.t...................hhGslhKs......hh.s.p...........................................................................................t..h...............s.spclhsVslMPC..hAK.KhEsp...R.s.-.hts.....t....................................................cVDhVlT.o.c....EL.s.p.hlc.............................................pt..........sIs..ht...plts.....pp..h.Dt...h.........................s.......touu...u..hl....................................................................F.........................................u.soGGlhcushp.hht.h....................................................................................................................................h..phshspGh....t.sht.phl.p..th....ct............................s.................................................................................c...........hpal.Eh.sC.....t.GCh.G...................................................................	0	435	630	751
+2501	PF02256	Fe_hyd_SSU		Iron hydrogenase small subunit	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_3750 (release 5.2)	Domain	This family represents the small subunit of the Fe-only hydrogenases EC:1.18.99.1. The subunit is comprised of alternating random coil and alpha helical structures that encompasses the large subunit in a novel protein fold [1].	21.70	21.70	22.00	23.20	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-8.88	0.72	-3.96	109	999	2009-09-11 10:48:27	2003-04-07 12:59:11	12	61	583	10	362	911	20	58.20	34	10.86	CHANGED	tssp-h.hppRtpulYphDpph.s...lR+SaENPtlppLY.ccaLs....cPh.uc+uHcLLHTc.Yps+p	.....................t....chhtpRhpuLYptD....pph.....lRpSa-NPtlppLY...c-aLs....cPh.uc+AHcLLHTp.Ypsp.........	0	185	271	316
+2502	PF01032	FecCD	FecCD_family;	FecCD transport family	Finn RD, Bateman A	anon	Pfam-B_377 (release 3.0)	Family	This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-11.87	0.70	-5.60	145	19091	2012-10-02 17:14:55	2003-04-07 12:59:11	13	11	3812	10	3276	15283	1729	306.10	28	92.97	CHANGED	ll..ll....hhlhu...L....hhGsh...tlshtplhpslht..................sshtt.........llhplRlPRhlhAllsGuuLuluGslhQslhRNPLAsPsllGlsuGAulusslshhhh............shhsh............hhhshhAh..lGuhlu...shllh.hlu.......httthsshpllLsGlulushhsulsshlh.hh....s.p..............phpslhhWhhGSl..s.stsappl.hhhhshllhshhhhhh.hu+pLslLsLG-chApuLGlslpph+hhhllhssllsusuVuhsGsIuFlGLlsPHlsRh...lh....G.sshpthlshoslhGullllhuDhluRhlht.PhE.l...PlG..lloullGuPhFl....aLlh+	........................................................................................................h.hhhhhhhu...l........hhGsh....tl...s...h.tp.l.h.p.h.h.ht.......................................ss..tph..................................l.lh.p.h...RlPRhlhullsGu......uLulu.Gs..lh....Q.s...l..h+NPLA.sPsllG..lsuGAu..hu.hsl..slhhh...............................shhsh.................h.h.h..s.....h...h..A.h.....l.G..uhls..............sh.l.l.h..hlu.................t.p.t..t.hs.s..h..p....l....l...L......s......G...l.u...l.u..s.h.h..s...uls..sh..lh...hh.......s...p.................................................php...p..l...h...h...W.h..h.Gol............s...ss......sa...p............p............l..hh...........h.h.....s.hl.l.l....s.lh.h.s....h..h.......h......u.....p.....t.......LslL.s.L.G.-..c..hApuLGls...l...pp...h+...hhhllh..s.slLs......u.....suVuhsG.s.I...u.F.l.G..L.l...s..P.H.l.s.R.h....l.s......G...s.....ct+...hhlP.h.............us..............Lh...G..ull.......Ll.h........u...D....hl...u.....R...h.....l..........h.................Ph.......E.......l....................P.l.G...l.l..s.u.l.l.Gu.P..h.Fl.aLlh+......................................................................	0	941	1977	2706
+2503	PF04773	FecR		FecR protein	Bateman A	anon	Pfam-B_3234 (release 7.5)	Family	FecR is involved in regulation of iron dicitrate transport. In the absence of citrate FecR inactivates FecI. FecR is probably a sensor that recognises iron dicitrate in the periplasm.	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.33	0.72	-3.76	182	4810	2009-01-15 18:05:59	2003-04-07 12:59:11	8	61	1004	0	1571	4630	1229	97.30	25	26.17	CHANGED	s................plpTs..s........sp.........ptplt...l.sDG.....op.lpLsssopl...............htttppp..lp....LhpGp....s.hhpssp.ssp.......t....Fplpo.s.sspltstG.T..pF..sl..........t..tpsspsp.....lsVhcGpVp	........................................................................t..h.os..h.Gppt.plp..L..s....D..G.......op..lhLsssSpl...................phshshs.pcp.h...lp.............lpG.E........s.hhc...V.....s+..ssp...................pP.......FhV.......po.........s..p.......s.......p.......l..pV...l.G...T.......pF...p..s..........h......tps.stsp........lslhcGpV............................................	0	637	1127	1377
+2504	PF02388	FemAB		FemAB family	Bateman A, Mian N	anon	Pfam-B_1214 (release 5.2)	Family	The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan [1]. These proteins are also considered as a factor influencing the level of methicillin resistance [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.23	0.70	-5.79	46	2929	2012-10-02 22:59:21	2003-04-07 12:59:11	11	8	1044	13	402	2189	375	322.00	26	95.28	CHANGED	losp..............................EacpFsppps..ssahQosthtcl+ttpshpschlGlccspspVhuAs.....lLhpthshhuaphhYhsRGP....lhDasspcLlpaahppLpcasKp......ppuLalplDPhlhhphhstsGc.h......s.psptllcphpplGacapGhsp.uass.hQsRaphllcLcshs--plhp.shspps+pslK+upphGVcl+hl.st.-E.........LstFtclhppT.p-R+sap.Rs.sYYpchhcpa.s-p.uh..lhlAplshpchlppLppphpphpppltphppt.tpp.pp.............Kpps+hpphppphps.ppclpcspchhpptup..lsLAuuLalhpspEshYLauGossc.........apcahushhlQachhph.Ahc+GlshYNFhGIsGpF...spss....GVh+FKpsFNupl.EhlG-FhhPlpPhhYplh.phlc.......K	......................................................................................................s.pEaptaspp....sphh.Qs..t.hhp.h+.....p.s..h..p..s.ph..l.u.lt.p..p...t......t...........l..h.sus..................l.l...hp.........h.........h.....h........h.....hhY....scGP.......lh..Da...p....s.t...p...h.l.phhhp....t....Lp.p.a.h.+p......ppslhlhhc..P.h.....hp.....h......t................................s.pthh...p..hp.p.hG.a...pa..pGhpt...th.ss...Q....c.........a.hh.hh.sl.....p.....t.......h.....s.t.c........p........lhp.ph.s.t.p.t+ptl+....p....s....h....p.....h....G....l..plchh...ph....-p.............hp.hFhpl.....hp.....T...tc...+....c...t...at......+...s.....pY..apphhc.ha...t-p...s......hhlA.lshpph.tplp.p.t..ptphtth.tt.........................pt.pphtp....pp..phtt..ppchtp.......hpth......tp.st....lsluuul.hhh..s....pc.shY..h.h.uGossc.........appa......h..us.hhhpaphhph.u.h.p.p.s.hs......hYshh.G.lps.th..................st.p.s......GlhpFKpsa..s...s......l....c...hhG.cF..hshp...hYthh.phh.....................................................................................	0	151	260	364
+2505	PF04023	FeoA		FeoA domain	Bateman A	anon	COG1918	Domain	This family includes FeoA a small protein, probably involved in Fe2+ transport [1]. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators.  This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.45	0.72	-4.01	284	5362	2012-10-01 19:11:18	2003-04-07 12:59:11	9	18	3214	52	1271	3443	369	72.70	22	50.92	CHANGED	hsLsp..lp.G......ppspl......tp.lpt..........p................................tthh............p+..LhshGlhsGsplpllp.ps.h..ssslhlpl....................p.sp.......h..s.LppshAppIhVch	..............................................Ltp..hpsG...ppspl..pp..lpt......t.............................tstht...p+LhshG...lh.Gsplpllp.ts.........sh......ssPlhl.pl...................................c..st...p....l...s..LccptAptIhVp................................	0	485	947	1153
+2506	PF02421	FeoB_N	FeoB; 	Ferrous iron transport protein B	Bateman A, Yeats C	anon	Yeats C	Family	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.71	0.71	-4.95	147	3662	2012-10-05 12:31:08	2003-04-07 12:59:11	13	24	2856	55	802	32060	12341	155.20	43	23.61	CHANGED	hplALsGNPNsGKTTLFNsLTGup.Q+VGNWPGVTV..EKKpGphp...h......ps.pph.pllDLPGh.....YSL....os..hS.-EtluRcall.....pcc.sDlllNllDAoNLERNLYLThQLlEhs.hPhllALNMhD.AccpG.hpIDhppLpchLG.lPVlsssApcspGlccLhctl	...........................................................................h.pluLlGNPN..sGKToLFN....t....L...............T...........G........u...........p............Q.......+.............V........G.......N.......W............s......G........V........T..........V........E......+....K....p....G..p....h..p......h........................ts......p..p.......h.....p.l..l..D........L.......PG.s............Y...S....L..................ss....h...S..........-......E.....p......l......s.....p.....c.....a.....l.l...................p..p.....p......s...D............l.....l............l............N.........V.....l............D..............A............o.............N.............L.............E............R.............N........L................a..........L...........T........h.......Q..........L...........l...........E..............l............s............h............P......h......l.....l..........u......L...N.M...h.D...h.............A...........c...........+...........p............G........l......p.........I.........D...........h..........c...........t........L.......u.........p.....p......L............G...........s........P.........V.......l.......s....l...s.A.pc..s..c..G.lcpLhpt.h.........................................................................................................................................................	0	308	571	698
+2507	PF00142	Fer4_NifH	fer4_NifH; 	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	Sonnhammer ELL	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.62	0.70	-5.21	14	20327	2012-10-05 12:31:08	2003-04-07 12:59:11	13	8	3168	72	446	26260	3397	132.50	67	98.47	CHANGED	RpIAIYGKGGIGKSTToQNhsAALAchG.K+VhllGCDPKADSTRLlLtGKsQsTll-hht-cGt..E-lpl--VlhpGatslcCVESGGPEPGVGCAGRGVITuIshLEE.GAYs.D.lDaVhaDVLGDVVCGGFAMPIR-sKAQElYIVsSGEMMAlYAANNIsKGlhKYAcpGG.VRLGGlICNuRpsDpEpEll-paAcplGophIHFVPRDNlVQ+AEhp+pTVhEasPpss....QApEYRpLA++Ih-Nc..hlIPpPloMD-LEsllhcaGlhc	...........................................................................................................................................................................S..T...R...L..l..........L...p....u.......K....A....Q.....s......T.............l........L..............c....h........A.u.........E..............t....G..s..........V......E...............D............L........E..........L....E....D..V....h......+.......h........G......Y.........t.....s............l.......+......C.....V....E.....S...G...........G...P.....E.....P.....G.....V.G...C...A.......G......R....G....V....I...T....u...I....N......F.....L...E....E....p....G....A..Y....-.......-.........l..DaV....Y.D...V........L.G...D....V...V...C..G....G..F..A...M..PI.R...E....s......K...A....Q.E.I.YI.V.hS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	138	291	373
+2508	PF01794	Ferric_reduct		Ferric reductase like transmembrane component	Bashton M, Bateman A, Finn RD	anon	Pfam-B_728 (release 4.2)	Family	This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane [1]. The Frp1 protein Swiss:Q04800 from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake [1]. Cytochrome B-245 heavy chain Swiss:P04839 is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants [2]. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterised by the absence of a functional plasma membrane associated NADPH oxidase [3].  The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease [4].	24.30	24.30	24.30	24.30	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.97	0.71	-4.04	209	4658	2012-10-03 10:28:09	2003-04-07 12:59:11	14	103	2096	0	2249	3954	660	129.60	19	25.54	CHANGED	tGhh.uhhhhshhhl........lu...h+....s.h....htthshpp....hhh.hH+hluhhshh.hshlH...........shhahhhhh.......................................tthhtthhtp.hhh.......................hGhluhh.......................................hhhhlhlsS......hthhR.+hs............YchahhhHhl.hhh.............................hhllsh	.....................................................................................huhhhh..shshl................................ls...h+.........s.l..........h.tt.h.s.hpp...........hhh..hH+h.........lG......hhsh.h..hu....hlH............................sh.sah.h.h..h.hh...........................................................................................hhtth..h..p..p..s.hh.h............................................................hGh...l...u.hl...........................................................................lh.hh.lhh.sS...........hthh.p...+hs................................................achahhhHpl..hh.lhhlhh.h.............................................................................................................	0	573	1182	1798
+2509	PF00762	Ferrochelatase		Ferrochelatase	Bateman A	anon	Pfam-B_879 (release 2.1)	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.91	0.70	-5.46	217	4061	2012-10-01 23:23:09	2003-04-07 12:59:11	14	15	3675	58	1013	3123	3342	305.40	29	88.92	CHANGED	+hulLLlNlGsP-ss..psVc.aLpp...hh..sD.cllc...lP......hh..hLtthIh.hRst.cssctYppl..s..s....sSPLhthTcpQsptLpptLspt..........................p..h.VhhuMRY.spP.l.pcslpplpp.p..Gs.....ccllllPLYPQYSsoTouoshcpltcsh..tp..............ht..sp....lc.hlpsaascPsalpAhspp....lppthpp.h..............tp.........spLlhShHGlPpph.l.ptGD...............................P.....................................YtppsppTs....chl.tct........................................L.....shpp................aplsaQSR.hGs..tcWLpP.TsctlcpLspp.G.h..+plhlhs.uFsuDplETL.ElshEh.+-hhtctGs...ppaphlssLNssstalpsL...scllppph	..............................................hulLlhNhGoP-s....psVctaLpphh..pD.p.+llc......hs......h..hlt..hl......hRst.cl.............sctYppl.................s.....ssSP..Lh..........th.o..c...pQ.sp...tLpptLsp...........................................p.h..Vhhu..h.+Y.usP..l.ps...sl.pphp.t..p...Gl................cc...llll..sL..YPpYS.soTsuush-pltchh....tp...........................h...p.....lphl.csaaccs.taIpshupp....lppphtph..................................tc............shLlhShHulPpph.h..ctG.D...............................P................................................................Y.ppspcTs.......chltpt.............................................L...............shsp........hthsaQ.S+.hG....t.WLpP.sp-t..lcpL......scp.....G...h.............cplhlhs.s....uFsuDplETL.ElshEs..+....c.hh.h.....ch..Gs......paphhsslNssstaIchlsslltt..h................................................................	0	298	610	840
+2510	PF04060	FeS		Putative Fe-S cluster	Bateman A	anon	Bateman A	Domain	This family includes a domain with four conserved cysteines that probably form an Fe-S redox cluster.	20.50	20.50	20.50	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.70	0.72	-4.37	19	2487	2012-10-03 08:56:42	2003-04-07 12:59:11	8	151	1933	7	725	1862	213	34.40	47	12.10	CHANGED	lLPpoNCGpCGassChsaAptllpscsclscChsh	........lLP.psp.CGpCGY.P.GCcsaAcAl.s.p.s..t.s.p.l.spCsPG................	0	301	522	632
+2511	PF02941	FeThRed_A	FeThRed; FeThRed_beta; 	Ferredoxin thioredoxin reductase variable alpha chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	25.20	31.40	24.70	18.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.12	0.72	-4.04	17	112	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	88	8	52	119	22	69.00	49	52.62	CHANGED	lGDRVRVpsSVlVYHHPpHRspsFDlp.GhEGEltsllspWpGRsISANLPhhVpFs...........KF+AHL+--E	...lGcRVRVpss.VhVYHhP...+stshDlp.GhEGcVtp.hl...spW+G+...lSANLPhhVpFph..........+Fh.AHL+EDE....	0	12	35	45
+2512	PF02943	FeThRed_B	FeThRed_alpha; 	Ferredoxin thioredoxin reductase catalytic beta chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	19.30	19.30	19.50	23.60	17.80	16.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.48	0.72	-10.95	0.72	-4.34	20	255	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	215	8	133	258	35	99.20	36	71.12	CHANGED	csLEsh+KFuEpYAK+oGTaFCsD.uVTulVlEGLA+HK-phGusLCPCRHY..EDKpuE.VtssaWNCPCVPMRERKE.....CHCMLFLT....P-N....FuGppQcIsp-plpcpp	..............h-hh+cFs-paAc.+sGhaFssDtslTssVl.cGLucpK-chGtshCPCRhh..-c+pt-...pt.h.CPCl.hREc..c..........CHChLFlo........-.........t..............t................................	0	48	107	123
+2513	PF01846	FF		FF domain	Bedford MT, Bateman A	anon	[1]	Family	This domain has been predicted to be involved in protein-protein interaction [1]. This domain was recently shown to bind the hyperphosphorylated C-terminal repeat domain of RNA polymerase II, confirming its role in protein-protein interactions [2].	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.44	0.72	-4.01	149	2377	2009-01-15 18:05:59	2003-04-07 12:59:11	14	41	279	21	1493	2278	3	52.50	24	17.77	CHANGED	cscpsFp.pLLc-tp....lsspo.........pWp...chhp..hl.ppDsRa..hsl.....pstpc+.cplFpca	...............tcpsFp.plLc-.tp............lsspo......................................pWp.....chhp......hl.t......p.....DsRa......psl......tstp-R..cplFpca.....................	0	421	703	1108
+2514	PF05013	FGase		N-formylglutamate amidohydrolase	Bateman A	anon	COG3741	Family	Formylglutamate amidohydrolase (FGase) catalyses the terminal reaction in the five-step pathway for histidine utilisation in Pseudomonas putida. By this action, N-formyl-L-glutamate (FG) is hydrolysed to produce L-glutamate plus formate [1].	20.40	20.40	20.60	20.50	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.41	0.70	-4.46	188	1531	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	783	10	479	1356	624	215.20	26	74.23	CHANGED	sss.lllsssHuGptlP..ssh...thshs.sthth+huh........Dhhscplhpths.th.....sAs..........lltuph....SRhllDhNRss.chsshh.........................stsshshlP....s...sp.lh.....thsts-tppRlpphapPYHsslsphlsphpsp.hshshllssHShsshh...sh.............shplGshas............s...ss....plspthhsthp......ssh.............s...lspNpPYsG.uhhspt...htt.spGhtslplElppsLhhs	.........................................p..PlllsssHuGpplP..ssh.....thshs...stht.p.hst.................DhalcpLhpths.th.....sAs..........hlt.upa......uRhllDh.NRss.chs.h...........................stustshlP.....s...s.p.hh..........t.sss-ttpRlpphapPYHpslpthlschpsp.aGhslll-sH.Shssh..h....shh..................hssasl..Gsths..............st..ss....plspthhphhp......sts..............hs.sshNtP.apG..uhhscp........hststpshp..ulplElppshhh................................................................................................	0	118	271	364
+2515	PF00167	FGF		Fibroblast growth factor	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans [2]. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerisation of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors.  These receptors can each bind several different members of this family.  Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular [2]. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.52	0.71	-4.34	77	1638	2012-10-02 19:42:32	2003-04-07 12:59:11	13	13	202	252	751	1462	0	113.10	32	52.07	CHANGED	RhtpLYsps..saaLplhs.....sG....pV.sGoppc..sstaulLplpus....sh.G..hVtI+usposhYLsMsccGcLY.......u...s..........pphs.s.-ChFpEph.-NtYssYtStha.....................tcshaluls+pG+s++Gp..+s...+ptppsspF.....L	................................................................hpLaspp.....uhaLpl..s...............sG...............pl.s..G...s...p..cc.............ts....a...s...h.....l.pl.sl....................sh..u...hVs..I.pGlp.o.shY.lsM.N.p.c.G.cLa.......u....o..............................pp.hs....s..-ChF..p.E...pl.....E..N.t..YssYtStha.....................................ptaaluLs+p.G.pshcGp...+s+.tp..spFh....................................................................	0	98	159	373
+2516	PF00370	FGGY_N	FGGY; 	FGGY family of carbohydrate kinases, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.34	0.70	-5.06	13	14797	2012-10-02 23:34:14	2003-04-07 12:59:11	16	35	4137	100	3453	10824	3157	231.80	24	48.40	CHANGED	hhlGlDpGTousKAllhs.cpGcllustptphshhpPcs..GasEpDPc-lapsstpslppllppt....tho.ppIpuIulouQt+uslllDcps.cPLhsAIlWsDsRTsshscpLpc..phs.pplhphTG.shhshaolsKLpWlp-pcPchhcphc....pahhs+-YLpa+LTG.....pasTDhosASsohhaslpstcWDcplLphlGIs.s...hLPpllpouclhGplpsphAthhGh..slPVsuGuuDssuuslG	..................................................................................................hlulDhGTous+..s..l...l.....h.........s....p.......p.....G......p..............h....l.......u.......t......t.......p...t....t....h......p...............h......h......s......p.s................G.a...s....E.........p.......c........s..p..........p.........l...a...p...s.....h...t...p.s....l.p...p....s...hpps........................th.p....p...p.......l..t....uI...G..........l..........s.........s......p..........t.......c........s..........h..........l..l.........h.............D.........c...........p..............s....p...............s...................l..................h...........s...........s...........I...................s................W.p..D..p..R..s...s..p...h....s....p....p........l............p...............p..............t....h.................h.........t................p..............t...........l................h................p................h........o.........G................h...........................h.......t................s..........h......h................s......h...s......K.........l.h.....Wl....h.c...p......s.t...h..h....p.p.sp................hhh.h.h....s.sa.lh..a..p.L..T.G....................t.h.s..s..D....h.....o.s..A..u...p.....T..h..h........h..........s.....l.....p..........p......h..........p........W........s........p........p........l........L...p.....h..........h.......s.......l...s...pp..................hl......P......p........l.......h......p........s...u.....p..h..h.G.....p.......h............p...t.t.....h.............t.............t....h....h.....u...................................................t..............h...P........l.s.s..s.s.sDptuuhhG...............................................................................................	0	1153	2092	2847
+2517	PF02782	FGGY_C		FGGY family of carbohydrate kinases, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.30	0.71	-4.70	105	14710	2012-10-02 23:34:14	2003-04-07 12:59:11	11	34	4144	98	3368	11639	3173	190.40	23	38.30	CHANGED	hthshGToshhhh..ts........spPh...tspuhhsshs...........................s..........shhhh-GspsssGslht.alhp........htthtpttt...................p.hst..t..ssss.s................sthhhh.....Psh.sGpts......Phhsspttusl..................hGhs.sps....huphhpuhlEuluhthRthlcth............tp.......................uts...hsslhhsGGts.cssllh.Ql..................hADshG..hPlhhsps.s-usslGuAhlu..uhAh	...............................................................................................................................h.ohGTushhhh.....ss............pp.sh........s.pu..h..h.s..s.hs..................................................s.tas...h.p.G..s.h.h.s.u.Gs.s..l.p....Wlpct.h................th......h.tpttp.........................p.hs.................p.ts...ss.....................ss.l.h..hl..........Phh..sG.....ts...............P...h.h....s..s.ps+..G......s.h.................................hGl.o...h.s.ss..............ps.clhR...A...s.....lEu....l...u.a...p...h..p.s.....s.l.csh.........ppt........................................................................Ghp........hpplt.l..sGGuu...pssh.h.h.Q.h..................h.ADlhs.......hsl...h............sts...t......E...ssALGAAhhAulu.............................................	0	1123	2048	2789
+2518	PF00498	FHA		FHA domain	Finn RD, Durocher D	anon	Prosite	Family	The FHA (Forkhead-associated) domain is a phosphopeptide binding motif [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.42	0.72	-3.85	221	10726	2012-10-01 21:55:46	2003-04-07 12:59:11	21	374	2041	93	5327	10014	968	70.70	25	13.00	CHANGED	hplGRs...........ts.s-ls...ls..............s...tt.lS+pHut...l...phpss.............................phhlpD.....ht....SsNGT.al.....Ns......pplpt.................hpLpsGDh.lplG	...............................................hlGRs.....................ts..s..c.lh.......ls.................................s......t..lS.+.p.Hup...l......phpss.................................................................phhlpD...............................hs..........SsN.G..T...a.l...........Ns.............pplpp............................h...Lp.sGDh.lplG...............................................	1	1945	3258	4503
+2519	PF00771	FHIPEP		FHIPEP family	Bateman A	anon	Pfam-B_983 (release 2.1)	Family	\N	20.50	20.50	20.80	23.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	658	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.96	0.70	-6.20	180	3878	2009-01-15 18:05:59	2003-04-07 12:59:11	15	8	2246	8	680	2701	953	594.50	38	94.91	CHANGED	sIlshhllPLPshlLDlhlshNIslSlllLhlulalp+PL-FSsFPolLLlsTLhRLuLNlASTRlILhpGc......AGcVIpuFGpFVlGG.....NhlVGlVlFlILsllpFlVITKGupRlAEVuARFTLDAMPGKQMAIDADLNAGlIspc-A+pRRpclppEucFYGAMDGASKFV+GDAIAGllIhhINllGGlhIGlhQ+shshucAhpsYolLTIGDGLVuQIPALllSsAAGllVTRsu.spp.....shupplhpQlhspP+sLhlsuullhhhullPGhPplsFlhluuhhuhhuahht+pp................................................ttttttsttpt.................tttttpshpshhps-...sltL-lGasLlsll-tsp..sut.LhpRlpslR+plup-hGhllPsl+l+Ds.hpLtssp....YpIplpGlplupuclhsschLAls..ssts..t................pl.sG..htsp.....-PsFGhsAhWIstsp+cpApttGa.............sVVDssoVluTHLscll+ppus-LlGhpEsppLl-pl........ppphPcLV-El.hPchlsluplpcVLppLLpEpVuIRcltsIlEsLs-hu.sps.cDsthLsEhVRtuLuRtIs....pphtss...p.spLsllsLssplEphltpul.pp.tsts.s.......hlsl-Pshsppl..lpplppth...pp.htt........tGtssV.LlsusslRhhlp+llcphh.s.plsVLSasElsssh.pl	....................................llshhllPLPshllDhlhshNIslulhlLhluhahpcsL-FusFPolLLlsTLhRLuLNluoTRlILhpup.................AGcllpuFGpFVlG.G......NhslGlVlFhILhllpFlVITKGupRlAEVuARFoLDuMP..GKQMuIDA....DLsAGlIspppA+pRRpclppEupFYGuMDGAuKFV+GDAIAGllIhhINllGGlhlGhhQasMshupAhppYolLTIGDGLVuQIPuLllShAAGllVTRls..ssp.........shupplhpQLhs.pPp.slhlsuu.lhhlhul.lPGhP....p..hsFlhhus.hlhhh..u.ahh.ppct....p.......................................................t..t......t..p...t..t..t..h.p..t.............ttpttp.t..sh.ss.l.........h.-....sl.tlclGh.p.Llshlctt.p...ttp...L....h..p+..I...cslR+phup-hGhl.hP..l+l.........R...-s..hpLpssp....YtlhlpGlplup.uc.lhssphhsls.......su.ps.hs................pl..sG........sh..............-.P.s..a.G..h.....suhWIpt.s.p..ppAph.Ga.............sVl.-.ssoVlsTHLscllpppss-lhGhpEsppLl-pl........pp.phPcLl--l.h................p..hlslspltcVLppLLpEplsIRDhtoIhEs....Ls....-hu...sh..........p....pD..s.hLsthVRhuLtRtIs....p.ph.h...s.s..........t.spl...plltLssplEphlhp.ul..pt..t..t..tu.t.........hhsl-Pshspplhpphppth..pp....t................h.u.t....ssV.LL..s.s..slR.hlp+hlct..h..s..pl.VLSatElssphp.............................................................................................	1	210	402	531
+2520	PF01269	Fibrillarin		Fibrillarin	Finn RD, Bateman A	anon	Prosite	Domain	\N	19.90	19.90	19.90	19.90	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.40	0.70	-5.44	42	616	2012-10-10 17:06:42	2003-04-07 12:59:11	12	7	468	19	394	756	165	215.80	57	78.68	CHANGED	lc.H.+atGValsc.sctst..LsT+NLsPGppVYGEKhlphpsp...........EYRlWNPaRSKLAAAIlsGlcph.I+.GuKVLYLGAASGTTsSHVSDIVG.cGhVYuVEFS.RshR-Ll..shuccRsNllPIltDARpPpcYRhLVt.hVDllFsDVAQP-QAcIluhNAcaFLKsGGahlluIKApsIDsTtsPctVFtpElpcL+c...pshcsh-pl.sLEPa-+DHAhVlGha+h	...........................................................cPH.+atGVFls+.G+cDh..LsT+NhsPG.....cuVYGEKRls..l..pss................spKhEYRlWNPF..RS..K...LAAu.Ilu.G.........l-p.la..lcPGuKVLYLGAASGTTVSHVSDlVGP................pGhVYAVEFS+....R...s...G...R..DLl..s.h..A..c..+...R......s..Nl..lPI...l...E...DA.......R..+...P...t.+Y...R.M...L...V...........s..MV..Dl..I.F.u.D..VA..Q...P............DQA.RI.l.ul.N.A.chFLKsGGth.l.I.S....I.......KAsCIDS..Tss..s..E..s.....VF...A..........p.EV..pKL...pp...-phKPhEQl.oLEPaERDHAhVlGhYp.....................................................................................................................	0	137	227	320
+2521	PF00147	Fibrinogen_C	fibrinogen_C; 	Fibrinogen beta and gamma chains, C-terminal globular domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.82	0.70	-4.76	11	4781	2012-10-01 23:56:02	2003-04-07 12:59:11	13	214	1032	239	2185	3828	41	153.80	35	42.42	CHANGED	.s+DCp-lhpp..GucoS...thYhIpPcssp.cshcVYCDMcT-sGGWTVhQpRpDGSlsFtRsWcsY+pGFGNls............sEaWLGNDpIppLTptG..shcLRl-LcDapG-pshAhYssFpVps-ss+YpLpVssYpG.sAGsAh........stscoMThHNGMhFSTaDRDND.....ssptsCupp.uGG...WWYspCHuANLNGhYYaGushshp........sGVsWhsWKGp.........YSh+pspMKlRPh	.............................................................................s.......thh...l...........................................h.......shC.-........p............t...s.....G.....G....W.h.....l.h....Q....p...............R...............s......G....p........s.....F.......c.t.......Wt.......p.Y.p...G.F..G.p.t................................sEaW..l....G..ctlh....lT......t..t..t................t...........Lh.lp..h......t....s......h.............s....p............h..............h.A........Y.....t...........tF...........l.....t.....s.....tt.p..Y.t.L.t.l..t..t....a...p....G.............................................................p..ps..h.FST..h.D..p........DND............................t.tp.C.u................t.....G..u.....WW.a.......p....t.....C....h..........s....p.....G....................................................................................................................................................................................................................................................................................	0	849	987	1634
+2522	PF03516	Filaggrin		Filaggrin	Griffiths-Jones SR	anon	PRINTS	Repeat	\N	25.00	25.00	27.30	25.00	18.30	24.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.81	0.72	-3.51	10	278	2009-01-15 18:05:59	2003-04-07 12:59:11	8	19	11	0	38	231	0	53.10	57	24.32	CHANGED	-uSRpSsu++HthSo+...ADSSRHSpsGQGQuuuu+o..SR+.pGSSsSQDSDSEGH	.....-tuRpSsuc+Ht...Sp+....ADSSRHStsGpG..Q.uS.uuhs..St+.pGSSsSQsSDSEGH...	0	23	23	23
+2523	PF00038	Filament	filament; 	Intermediate filament protein	Sonnhammer ELL	anon	Prosite	Family	\N	40.00	40.00	40.00	40.00	39.90	39.90	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.07	0.70	-4.96	33	4874	2009-01-15 18:05:59	2003-04-07 12:59:11	16	38	268	31	1988	4185	5	271.60	33	60.33	CHANGED	sEKcphQsLNDRhASYI-KVRtLEppNptLEs+lpphppp..p.....tspssphtshYppplp-LRppl-shst-+u+lpl-l-Nhptsl--h+pKaEcE............................hshRpssEs-lssLR..............+slD-toLs+lDLEt+lESLpEElsFLKphHEEElp-Lps....plp......splsVEhDs.s.phD....LsphLp-lRuQYEslAp+N+p-AEphYpsKhpcLppssspss-tlpsuKpElsEhRRpl...QuLphElpu....lpupppuLEppltEsEpRastplpshQstlspLEppLpph+p-MtRplpEYQcLLsVKhALDhEIATYRKLLE.GEEsR	.................................................pEKtphptLNs+h.A.sa.l.-.K..................V..R...LEppNt....L-...schp.h.pp...........t..t...s..t.....sha...t.l...p........p..L...+..pp.............l...phtt-p......u...pl..h.plcs.h...p..th-...........c....h..+..t...+..a.Ep.E..................................................hsh.R.p.psEs-h..ssl+.................................................................................................+..slD.p....h.hhs+s.-..LE....tp....l-uLp......-.El...t.a.......L.+.p....a....-...c............El....p..plps.............plt.......spl.l...c..hD...s......s....p...D..............Lsp..hl.t..-...l.R.......s......Q.Y..E.p.l.s..pp.....s..+..t....-...s..E...p.h.a...p.........s.+..................h...............p...c.....lp......t....p.s....s.p......p....s....-.t.l.........p..ps.+.p...E.....l......p.......E...hp....+p..l.................pp.L..ph.El..ps...................................hp.s..................p...ts..L.Esplt-sEpphp...h.tl.pphps..h....lspLEt........pLpp.h+p-h..t.pphpE.Y....p.p.LhslKhtL-.hEIu.TY...R..+LL.E.GE-t..........................................................................................	0	179	311	802
+2524	PF04732	Filament_head	filament_head; 	Intermediate filament head (DNA binding) region	Kerrison ND	anon	DOMO:DM04896;	Family	This family represents the N-terminal head region of intermediate  filaments.  Intermediate filament heads bind DNA [1].  Vimentin heads are  able to alter nuclear architecture and chromatin distribution, and the liberation of heads by HIV-1 protease liberates may play an important role in HIV-1 associated cytopathogenesis and carcinogenesis [2].   Phosphorylation of the head region can affect filament stability [3].  The head has been shown to interaction with the rod domain of the same protein [4].	21.80	21.80	22.10	21.90	21.00	21.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.68	0.72	-3.28	45	462	2009-09-11 21:54:48	2003-04-07 12:59:11	9	4	64	0	185	404	0	84.80	31	16.72	CHANGED	tssSSYRRhFGs.............sts.p.uhss...st..ssuSshp...spps.psosu...s......pShttps.sssh...h.........-s.lDFSh.usAlNs......EFKtsRT	...................................psSSYRRhFGs.............shs.phuhss.........usuS.uhp.........spph..psSsu....ss.h...u.Sh..ptpsssssht......h.s...............-s.LDF.S..usAlNs......EFKsoRT..	0	6	27	78
+2525	PF00630	Filamin		Filamin/ABP280 repeat	Bateman A	anon	Prosite	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.48	0.72	-3.44	132	7961	2012-10-03 16:25:20	2003-04-07 12:59:11	14	217	181	75	3933	8351	79	92.40	27	39.51	CHANGED	sscssc.sps.....G.G.......l..pts.....hss.pss..pFplpsp.....ss.Gt...t........t....lpl......................tsspst................................................................................................................................................................th.h.....t...lp-pp.....................cG..sap.lpY.pPpps..Gp.aplpVph....ss.......p.plssS.PFp	......................................................................................................................................................................................................................................................s..sspclps............Gs.G...................L....pts..........hss..pss...pFslpsp...............sAs.s.s...................lt.......lpl...............................puP.sst................................................................................................................................................................................................hch....p.....lp.-.s..t...............................-.G.....o.a..s..VpY....h.P.p...p.s.....Gp..a..........pls....Vpa.....ss...................p..cl..P..s..S.PFp.............................	0	1135	1433	2563
+2526	PF01611	Filo_glycop		Filovirus glycoprotein	Bateman A	anon	Pfam-B_1023 (release 4.1)	Family	This family includes an extracellular region from the envelope glycoprotein of Ebola and Marburg viruses. This region is also produced as a separate transcript that gives rise to a non-structural, secreted glycoprotein, which is produced in large amounts and has an unknown function [1]. Processing of this protein may be involved in viral pathogenicity [2].	25.00	25.00	176.80	176.70	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.08	0.70	-5.66	6	92	2009-09-10 21:45:54	2003-04-07 12:59:11	11	1	25	6	0	98	0	322.40	54	65.93	CHANGED	+KTSFFlWVIILFQ+shSlP.LGlloNSTLQso-lDphVC+D+LuSTsQL+SVGLNLEGsGVATDlPoATKRWGFRoGVPPKVVsYEAGEWAENCYNLpIKKPDGSECLPsPP-GlRsFPRCRYVHKlQGTGPCsGslAFHKpGAFFLYDRLASTlIYRGssFAEGVIAFLILsKs++cFhpSpPh+EssNhTpsooShYaToolpYphssFGspposhLFclsspTaVpL-ssaTPQFLspLN-TIppssphSNTTG+LlWTlsPslD........oshGEWAFWETKKssocphpucohLSh.hhps+T.......pNhScpuss.....+pohpPus..ssTst.....ssppsssh.plPhpshpsssoppphpss.p	.............++TSFFlWVIILFQ+shShP.LGllpNSTLpso-lDphVC+D+LuSTsQL+SVGLNLEGsGVATDlPoATKRWGFRoGVPPKVVsYEAGEWAENCYNLpIKKPDGSECLPssP-GlRsFPRCRYVHKlpGTGPCsGshAFHKpGAFFLYDRLASTlIYRGssFuEGVlAFLILscs++cFhpS+Ph+EssN..hTpssoStYaToolpYphssFGsppophLFclsshTaVpL-spaTPQFLhQLN-TIh.tssphSNoTG+LlWplsPplD........sslGEWAFWETKKs..pphhspp.lsh...pstt.......ps.stt........php.pstp...sTs......s.p.p..h.p...t.hpt..pp........h...........................	0	0	0	0
+2527	PF02097	Filo_VP35		Filoviridae VP35	Mian N, Bateman A	anon	IPR002953	Family	\N	22.40	22.40	54.20	53.70	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.96	0.70	-5.23	4	107	2009-09-11 13:24:37	2003-04-07 12:59:11	10	2	30	27	1	61	0	190.00	70	95.46	CHANGED	h.GPEhoGWlSEQLMTGKIPlo-lFsDl-NpPs.h.hphhspspsss+ss....sppoQTDshhs..hccVcpTLssLloslpRQssAIESLEsRlTT....LEsuL...KPV.DMuKTISSLNRuCAEMVAKYDLLVMTTGRATATAAAs-AYWsEHGQPPPGPuLYE-sAl+uKlcs.sshVPpuVp-AapNLsSTosLoEENFGKP.ISAKDL+pIhYDHLPGFGTAFHQLVQVICKI....GKDsNhLDhIHAEFQASLAEGDSPQCALIQITKRlPhFQDssPPlIHI+SRGDIPRACQKSLRPVPPSPKIDRGWVClFphQDGKTLGLKI	......................................................................................................................................................................................................................................................LALLLFTHLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFH....QILSEGENAQAALTRLSRTFDAFLGVVPPVIRVKNFQTVPRPCQKSLRAVPPNP.T.IDKG.................	0	0	0	1
+2528	PF00419	Fimbrial		Fimbrial protein	Finn RD, Bateman A	anon	Pfam-B_196 (release 1.0) & Jackhmmer:B2PIN3	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.27	0.71	-3.98	244	16321	2012-10-02 17:35:21	2003-04-07 12:59:11	15	9	786	91	829	6504	36	150.30	18	66.83	CHANGED	lshpu.sl......tsssCsl....s..ssss...................VsFG.slsh..s..plsss.........tht.pshslsls.........Csss.................slpl.thh........us.....ssshs..ssslts....sss..................slGlpl.......................................pps..ss.....h...................t........thsphhshshs.............hpAs.hp..tsssshs.t....GpFsAsuolplsY.p	...................................................................................phpG.pl......hsssCs...l........s..ssst...............sV.sh...G...plss.......s....phpss...........tssst.ts..F...slplp...........tCsss...............................tss.pl...shs.................us.......sss.ss....ss.hlss......sssss.t....................................ulGlpl......................................hss.s..sss.............l.....................thssss.......................s.hshssssss..........hs......................apAphhs..............sssssss...s............GshsAssshslsYp........................................................................................................	0	59	218	557
+2529	PF04449	Fimbrial_CS1		CS1 type fimbrial major subunit	Kerrison ND	anon	DOMO:DM04212;	Family	Fimbriae, also known as pili, form filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometres. They enable the cell to colonise host epithelia. This family constitutes the major subunits of CS1 like pili, including CS2 and CFA1 from Escherichia coli, and also the Cable type II pilin major subunit from Burkholderia cepacia [1]. The major subunit of CS1 pili is called CooA.  Periplasmic CooA is mostly complexed with the assembly protein CooB.  In addition, a small pool of CooA multimers, and CooA-CooD complexes exists, but the functional significance is unknown [1]. A member of this family has also been identified in Salmonella typhi and Salmonella enterica [2].	20.80	20.80	21.30	20.90	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.91	0.71	-4.14	13	326	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	291	4	19	128	3	139.00	45	81.62	CHANGED	VpKsITVTAsVDPTl-lLQADGSALPoulplsYhPu.pshpstplpT+IaTNDpoKslpl+LsssP.sLsNlhsPo.ppIPlsVohGGcsLoTous...olcuucL.FusuulsssSsshsLsIuts...Tsussss..AGsYQGlVSlllTQu	...................................................................VQKDITVTANlDusL-hhQsDs..o..uLP.p.sl.chpYhPG...pGL..sapL.T+l.a..SND..TK...cVphpL.luss.QL..l.p...sL.Dso.Khl..slsVThGG..cplps.suu...sh.pAspl.Fs..s..s..ths....suShs.tNLhhuQp....stusL..ps....G.YpGlVSlhlSQ..................................	0	1	9	13
+2530	PF02432	Fimbrial_K88	Fibrimal; 	Fimbrial, major and minor subunit	Mian N, Bateman A	anon	Pfam-B_2036 (release 5.4)	Family	Fimbriae (also know as pili) are polar filaments found on the bacterial surface, allowing colonisation of the host. This family consists of the minor and major fimbrial subunits.	25.00	25.00	29.00	28.90	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.57	0.70	-4.94	17	376	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	101	12	10	223	0	219.50	30	89.32	CHANGED	huG-lplsGhlTs....cshWsWplGsu.pshsssssch.spssplsIslstst..PlLhG+sh-sh.tG...GsGhsPploa.tuh-Ghsl.......shsssGpuphsLPVp.s-sssphGoLshslstuuslptspspp...................sha.GshhssshshlsGpotssssups.sht.........hhssphsshhp.....shpsuuh.s.shhocuslppltus....Yuuulstsps.chplstssss..hpWpAsLsVolsYp	........................................uGplplsGslTs...pts.WtWpVGsss.ps....h..s..schtcs............tssphslslstss...hPlLhG+sh.t.s..s..sG...tsGhsP.Isa..sspG.sh.......stsssuhhpholPVp..s-sss.ps..Gshshs.h.ptuusls.tshtsp................................a.Gs..h.hs..tsh...s...hl.s.s.p.usshstu.t.o.s.h..........hhssthsshhs.....ss.ss.u.sshs.uh..hs.D..upltplsus.....YAuslststs.-hphcts.sss...hpWpsuLsVoloYp..........................................................................	0	0	0	3
+2531	PF05182	Fip1		Fip1 motif	Wood V, Bateman A	anon	Pfam-B_4652 (release 7.7)	Motif	This short motif is about 40 amino acids in length.  In the Fip1 protein that is a component of a yeast pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase [1]. This region of Fip1 is needed for the interaction with the Th1 subunit of the complex and for specific polyadenylation of the cleaved mRNA precursor [2].	22.70	22.70	23.70	23.80	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.69	0.72	-4.69	36	388	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	282	0	249	374	4	44.70	53	8.76	CHANGED	h-hD.l-.shc-..KPWRcPGADloDYFNYGFsEpTWctYCp+QcchRt	................-hDl-..sh..--..KPWR+P.........G...AD..lSDYFNYGFsEpTWcsYCcKQcclR.......	0	86	141	209
+2532	PF02433	FixO		Cytochrome C oxidase, mono-heme subunit/FixO	Mian N. Bateman A	anon	Pfam-B_2045 (release 5.4)	Family	The bacterial oxidase complex, fixNOPQ or cytochrome cbb3, is thought to be required for respiration in endosymbiosis. FixO is a membrane bound mono-heme constituent of the fixNOPQ complex.	24.20	24.20	24.30	24.70	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-4.98	56	1201	2012-10-03 10:02:11	2003-04-07 12:59:11	10	7	1028	0	361	915	226	199.50	49	74.82	CHANGED	HphlE+NshlLhlhshlsloIGGlVEIsPLFal-sTI.EcV......................................................-GlRPYTPLELsGR-IYlREGCYsCHSQMIRPhRDEVERY....GHYSLAAEShYDHPFQWGSKRTGPDLARVGG.KYSDpWHlsHLhsPpuVVPcSIMPuYsaLtcst.LD...........hssltschpshptl...........GVPYo..-p...............IpsApsDhpuQAssps......s.hsshhp+Y.spAthp.......saDGssttloEMDALlAYLQhLGThVD	..............................................................................................HphlE+Nshllhlhh.ll.sl.ulGGL.V.E.I.l.PLFa...cs.s.hcsl..........................................................cGh+..P.YT..s....LpL.....tGRDIYIREGChsCHSQMI..R....P....F...R...u..E.s...E.R......Y.............G.......+.......Y......Sl.A..G.Ess........Y.........D..H.........PFlW.......GSKRTGPDLAR.VG.................u.+.Y...S....D....-....WHhsHLhsP..RsV..VP-ShMPuYsaLh...csp..lD.................scss.t.tc.hpsh+.p.l...........G.V.P.Yo..--................pIspAtpt.h.....cup.........................................................................................p...........................................................................................	0	111	233	301
+2533	PF01346	FKBP_N		Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	Bateman A	anon	Pfam-B_402 (release 3.0)	Family	This family is only found at the amino terminus of Pfam:PF00254. This domain is of unknown function.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.08	121	3385	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	1650	10	537	2180	296	111.50	31	49.55	CHANGED	shuhshsssttssss...........plpopppKhSYulG.hslGpphppphhc........lDhctllpGlpDuh..tssp.tlo-E-hpps...Lpphppclptppptpht..p........ApcNtpcGctFLs-NtpK-GVhsTp.SGLQYcV	.....................................................................hts..........................shps..cppsuYulG.hp.lGpph...ppphhct...............ls.-tl.htGlpDuh.....tu.p.ps....tl...st..pp..h..pps....L..pp.hp.pchpsttptp................uptst..scGctFLpcN.tc.+......c.GVpsot..SG.LQYcV..................................	0	144	275	420
+2534	PF04620	FlaA		Flagellar filament outer layer protein Flaa	Kerrison ND	anon	DOMO:DM04570;	Family	Periplasmic flagella are the organelles of spirochete mobility, and are structurally different from the flagella of other motile bacteria. They reside inside the cell within the periplasmic space, and confer mobility in viscous gel-like media such connective tissue [1]. The flagella are composed of an outer sheath of FlaA proteins and a core filament of FlaB proteins. Each species usually has several FlaA protein species [2].	25.00	25.00	25.60	25.50	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.02	0.70	-4.93	10	195	2009-09-11 10:09:13	2003-04-07 12:59:11	7	10	102	0	60	164	0	204.90	22	55.90	CHANGED	phshsshoslDa...ucsschuasutupth....hccuLshssW.Vthsuu...sp.....tsshhtts.scsputchuus+llGVRlpFsptGpNuhull....pPsatIPhhu.....................................slKoIuVWVaGtuY.asLplLlcDppGch+phhMGpLsFsGWKpLshs.NPsalsss+sR.lp.psshYPsussclshpGF+lccDssccsG-alsYFcDl...........+llhDhhsV-hsc	........................................................................................t....................t....t.tt......h.......pa...hs.s.............................sptt.stt.h..tspplLGV+spFsphu.sshs.hh.........tsshtIshhu..................................................hh.KplsVWVaGtsatasLplhlcDhpGpp....aph.h...G.pLsFpGW+pLp......hs..sPshls.......p.p.s.Ysh.ts.lphhuFtlppsstpthssahhYhc-l...........+llhDhh......p..............................................	0	29	46	46
+2536	PF03646	FlaG		FlaG protein	Bateman A	anon	Pfam-B_2985 (release 7.0)	Family	Although important for flagella the exact function of this protein is unknown.	21.00	21.00	21.20	21.40	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.20	0.72	-3.91	139	905	2012-10-01 21:18:35	2003-04-07 12:59:11	10	1	864	1	295	725	111	111.20	22	87.37	CHANGED	ststssssstsppsspsststs..................pptppptppp......tt...sppc.lp.cslpplschhps.hpps....LpFpl--cssc.hlV+VlDppos-VIRQIPsEchLclu....cplp-..........ht...........Gl.Lhcpc	.........................................................tsts................t.tt.t.................pptt.pttptp..........pp.hspcclp.chl.c.clNchhps...hs..ps.....lpF.pl..c-.c..s..sp.hlV....pVhD.ps..Ts-lIRpIPsEEhLclh....pplp-...............hh.................Gl.lh-p.......................	1	114	218	264
+2537	PF03614	Flag1_repress		Repressor of phase-1 flagellin	Griffiths-Jones SR	anon	PRODOM	Family	\N	24.00	24.00	25.50	65.20	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.88	0.71	-4.68	3	93	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	77	0	3	55	2	147.20	63	91.53	CHANGED	DISYGREAElWPRDYSsLARRlQFLRFNDIPVRLVSsNGQlIIGYIuKFNs+ENhI.LASDcsKGsNRIEVKLEpLAoLE....ELsusDuhstoLVssDhFNlQ.hsPSRRDFFSICNKCaKQGVGIKVYMtDGRlLpGcTTGVNACQVGlppuNGNHMQVMFDWVSRI	.DIoYGh.AEhWPR-YShlt+tl.FhRhspIPVRls.psuplhshYltth.spcNhI.LASDc.sKGspRIEVKLEpLAhLE....ELsusDs....hshoLVssD.FNlQ.hsPSRRDaFSICNKCaKQGVGIKlYMt.GplLpGcTTGVNACQVGlppuNGNHMQVMFDWVSRI	0	0	2	3
+2539	PF05149	Flagellar_rod		Paraflagellar rod protein	Moxon SJ	anon	Pfam-B_6464 (release 7.7)	Family	This family consists of several eukaryotic paraflagellar rod component proteins. The eukaryotic flagellum represents one of the most complex macromolecular structures found in any organism and contains more than 250 proteins [1]. In addition to its locomotive role, the flagellum is probably involved in nutrient uptake since receptors for host low-density lipoproteins are localised on the flagellar membrane as well as on the flagellar pocket membrane [2].	21.90	21.90	22.10	27.80	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.74	0.70	-5.21	13	124	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	28	0	18	115	0	271.00	42	47.55	CHANGED	scc.lothl-s+cph+ptscpDLc+lc-phpphssscscppcpapsp+pc.-chlppNp-pQppsaccIp-LtccLpc.......LupcRpc.V-cRlcttccEcpRcssappFlphuspHpptLppolpNsctulcsssplpshVt-uCcplsuh.p-chppsLu-hhhtlpc-+LctFRshYlshGcLhaKKE+RLEpl-+pIRhsclppEhuh-oLDPNAKcaucscc-Lhtt+ppVppplshlcp+hcpu.csFcPTEcuLht....AGlcFVHPh-ElpctslpRps+lL-Y+phhs	.........................ppssthh-s++ch+ppscpDLcplp-sIQcsDh-DucshKRausp.+c+S-.chlpcN.-pQ--sWp+Ip-LERpLQc.......Lus-Rh-EV+RRIEcp-REE+R+s-.appFLclsuQHK+hLcholhNCDhAhcssuhlE-hVsEuCsslcu+.aD+sppcLusLplpV+pEaLEtFRtLYhTLGpLlYKKE+RLEElDRpIRssHlQlEhslETFDPNAKcau-tKK-LhchRtpVEcELthL+-K.spAL-.FpsoEcuL.t....AGl-FsHPh-E.pctslsRRSKhlEY+s+l...............	1	7	13	18
+2540	PF00700	Flagellin_C		Bacterial flagellin C-terminal helical region	Bateman A	anon	Pfam-B_41 (release 2.1)	Family	Flagellins polymerise to form bacterial flagella.\	\	\	    There is some similarity between this family and Pfam:PF00669, particularly the motif NRFXSXIXXL. It has been suggested that these two regions associate [2] and this is shown to be correct as structurally this family forms an extended helix that interacts with Pfam:PF00700.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.57	0.72	-3.82	33	7466	2009-01-15 18:05:59	2003-04-07 12:59:11	16	27	2537	11	1427	5887	1917	81.80	34	21.70	CHANGED	lshlspA...lsplsshpupLGssQsRlcpssssLsspps.lssuhsclccVDhsctsochsphphhhQsuhulhAphspl..slLshL	...........................ttlDsA...lspls.shRusL...GAhQN.R.l.p.ps...l.s...NLsst.......spN.l....suu.p.ScIcDsDhApEsssho+..tplLpQAutuhLu.Q.AN.phs.p...slLpLL.......................	0	485	932	1156
+2541	PF00669	Flagellin_N		Bacterial flagellin N-terminal helical region	Bateman A	anon	Pfam-B_37 (release 2.1)	Family	Flagellins polymerise to form bacterial flagella. This family includes flagellins and hook associated protein 3. Structurally this family forms an extended helix that interacts with Pfam:PF00700.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.36	0.71	-4.38	34	9093	2009-01-15 18:05:59	2003-04-07 12:59:11	15	29	2631	13	1625	7111	2324	128.50	32	35.14	CHANGED	IsTshhu.ssppslspspsplsputpclooGh+hssut-.uushuhusshpsphssLsphscssshuhuhlpsspu..Alsphtsshpp.........lppLsstuussssssh..sppshpsplppLhspls.....TsaNGphlhuGsto	.......................................................lsss..s...s.pt...l...s...psp...s...t...hsp...shp+L.S...S.GhRIss.AtDD.uu.uhulupphpsphpuLspu.tcNs.scuhuhhQosEu..u.L.s.p...h.s...s.h.LpR.........h+-..L......u...l...Q...u....u...N..u...o..t.oss......D+....su....l.p.pE....l....p....pLh.sc...l.......spl..uspTp.a.N.G.pplLsGs.........................................................................	1	534	1032	1312
+2542	PF01350	Flavi_NS4A		Flavivirus non-structural protein NS4A	Bateman A	anon	Pfam-B_211 (release 3.0)	Family	Flaviviruses encode a single polyprotein. This is cleaved into three structural and seven non-structural proteins. The NS4A protein is small and poorly conserved among the Flaviviruses. NS4A contains multiple hydrophobic potential membrane spanning regions [1].  NS4A has only been found in cells infected by Kunjin virus [2].	20.60	20.60	21.90	93.70	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.65	0.71	-4.64	32	3233	2009-09-11 15:45:06	2003-04-07 12:59:11	12	17	110	0	0	3283	0	144.70	60	4.30	CHANGED	ssllcslutlPpahtp+stpAhDshYsLhsuEtGoRAa+tAhpElPEulpTllhlshLulhThGlhhhhht++ulu+hslGhlVlssussLhWhuslssspIAGshllhalLhlVLlPEPt+QRS.pDNpLAhhllslhsllGhV	.....lsLIpElG+lPpHhsp+spsALDNLshLHTuEpGGRAYRHAlEELP-TlETLhLLuLlullTGGlhLFhhSGKGIGKholGhlClhsuShLLWMApVpspWIAuoIlLEFFLMVLLIPEPEKQRTPQDNQLAYVVIulLTllusV..	0	0	0	0
+2543	PF01349	Flavi_NS4B		Flavivirus non-structural protein NS4B	Bateman A	anon	Pfam-B_211 (release 3.0)	Family	Flaviviruses encode a single polyprotein.\	     This is cleaved into three structural and seven non-structural proteins. The NS4B protein is small and poorly conserved among the Flaviviruses. NS4B contains multiple hydrophobic potential membrane spanning regions [1].  NS4B may form membrane components of the viral replication complex and could be involved in membrane localisation of NS3 and Pfam:PF00972 [1].	25.00	25.00	81.70	81.20	18.10	17.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.49	0.70	-5.45	35	3305	2009-01-15 18:05:59	2003-04-07 12:59:11	12	19	110	0	0	3287	0	244.40	64	7.42	CHANGED	NEMGaLE+TKpDlttlFht.ppp...ptpssshp......slDL+PAouWuhYushsolhTPhlhHhlpophtshuhuuluupAssLhsLspGhPFhslchsVshLslushsphTssoLhsulsLsshHauhllPGhpAphs+pAp+pshuGlhKNssVDG.lssDlsch-stsshhEKKlu.llLlsLslsulllsRsshuhtEAusLsoAAlspLh-ssssshWshssAsGhsslh.RGsahuslsl...sWshhpssc	....NEMGhLEpTK+DLG..hGphtt....pp.s.p.u.....h..LDlDL+PASAWTLYAVATTllTPMLRHoIENoosNlSLTAIANQAslLMGLsKGWPlSKMDlGVPLLAlGCYSQVNPlTLTAAlLLLlsHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIssIDL-Pls.YDsKFEKQLGQlMLLlLCssQlLlMRToWALCEAlTLATGPloTLWEGuPG+FWNTTIAVSMANIF.RGSYLAGAGLhFSlMp......p.........	0	0	0	0
+2544	PF00972	Flavi_NS5		Flavivirus RNA-directed RNA polymerase	Finn RD, Bateman A	anon	Pfam-B_200 (release 3.0)	Family	Flaviviruses produce a polyprotein from the ssRNA genome. This protein is also known as NS5. This RNA-directed RNA polymerase possesses a number of short regions and motifs homologous to other RNA-directed RNA polymerases [2].	19.00	19.00	19.00	19.10	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	649	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-13.14	0.70	-6.64	7	5252	2012-10-02 12:54:00	2003-04-07 12:59:11	15	19	173	49	1	4283	0	449.30	66	21.01	CHANGED	Th.sDlsLssGTRuVsttpsh..shptltcRlp+L+pEapsTWahDp-HPYRTWpYaGSY.scsoGSAuShVNGVVKLLohPWDsltpVTpMAMTDTTPFGQQRVFKEKVDT+s.-P.tGTRclh+ssspWLachLu.+cKpPRlCT+EEFIsKVRSsAAlGAhhpEpptWpoApEAVpDs+FW-LVDcERphHLpG+CcoClYNMMGKREKK.uEFG+AKGSRAIWYMWLGARFLEFEALGFLNEDHWhSRENShuGVEG.GLphLGYlL+-lup+pGGhhYADDTAGWDTRITcsDL-sEphlhphM..sscH+tLApAlhcLTYpNKVVKV.RPsscGt..slMDVISRRDQRGSGQVVTYuLNThTNhcVQLlRhhEuEGVIptpchpp.....hhtlptWLpcpGp-RLpRMAlSGDDCVV+PlD-RFusALpaLNsMuKsRKDIspWcPS+GWssWppVPFCSHHFHElhhKDGRslVVPCRsQDELIGRARlS.GsGWsl+ETACLuKAYAQMWsLhYFHRRDLRLhu.AIsSAVPscWVPTGRTTWSIHuptEWMTTEDMLcVWNRVWIp-NPaMpDKTslpuWcDlPYLsK+pDhhCGSLIGhppRATWAcsIhsulppVRplIGpEc.....YsDYhssMcRYpttt-.t	..................................................hE.DVsLGuGTRtlsh.....ss.phItpRIppl+pEat..poWHhDpppPY+TWsYHGSY-s+.oGSASShlNGVV+LLoKPW.Dsls.VTphAMTDTTPFGQQRVFKEKVDT+s.cs..Gst.lhp.TspWLWt..Lu.+pKpPRhCo+EEFhpKVpoNAAhGAhF.-pNpWpoA+tAV-D.cFWchVccERphHh.GcCtoClYNMMGKREKK.GEFGKAKGSRAIWaMWLGARaLEFEALGFhNEDHWhuRcN.ShuGVEG.G..Lp....+L.GYILR-..luph....GGthYADDTAGWDT.RIT.tDLpNEth.lh.p.h..csEHt.LApuIhcL.TYppKVV+V.RPs.pG...TVMDlISRcDQRGSGQ.VsTYuLNT.F.TNhtsQLlR.MEuEGlht...ph.p......t.tl.pWL.p.G.ERLpRMAlSGDDC..VV...KPlDD.RFA.s.uLhhLNsMuKlRKDI..pWpPSpGW.sWppVPFCSpHFppLlMKDGR.lVVPCRsQDELlGR..ARlS.GA.GWsl+-TACLuKuYAQMW.LhYFHRRDLRLhusAICSAVPspWlPTuRTT.WSIHuttpWMTTE.DMLpVWNRVWIp-NPWM..EDKT.VpsWp-lPYlGKRED.WCGSLIGhpuRATWApNI.sAIpQVRtlIG.p.E.p.....YhDY.MsSh+Racpp..........................	1	0	1	1
+2545	PF01570	Flavi_propep		Flavivirus polyprotein propeptide	Bashton M, Bateman A	anon	Pfam-B_304 (release 4.1)	Family	The flaviviruses are small enveloped animal viruses containing a single positive strand genomic RNA [1].  The genome encodes one large ORF a polyprotein which undergos proteolytic processing into mature viral  peptide chains. This family consists of a propeptide region of approximately 90 amino acid length.	27.60	27.60	28.20	28.30	25.60	27.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.42	0.72	-4.26	9	5590	2009-09-11 10:42:09	2003-04-07 12:59:11	12	23	116	2	0	4419	0	80.40	58	3.84	CHANGED	s+pG-shMllstp-+sculhh+sssG.NhCslhAhDlGchC-DTlTYcCPplsp.sEP-DlDCWCssss.saVpYGpCspsucpRRp+	.........o.RsGEPpMIVsppE+G+uLLFK.TusGlNhCTLhAMDLGEhC-DTlTYcCPhlsp.sEPEDlDCWCstos.saVpYGpCo.p..sucpRRp+...........	0	0	0	0
+2546	PF02525	Flavodoxin_2	NADHdh_2; 	Flavodoxin-like fold	Bashton M, Bateman A	anon	Pfam-B_1456 (release 5.4)	Domain	This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2.  These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species [1].\	    This enzyme uses a FAD co-factor.  The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy [1]. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP [2]. This family is related to Pfam:PF03358 and Pfam:PF00258.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.50	0.71	-4.81	247	7847	2012-10-03 05:08:30	2003-04-07 12:59:11	12	15	2899	188	1533	11821	2314	183.60	23	92.92	CHANGED	h.+lLll.ups.........ph.t.......uhspplspthhpthpptt......p....Vph.pDLhp......s.ht....................................................s.tp...t.hss....tt-p..pplhtADhllhthPha.auhPuhLKsalDpVhptGh.....sa.........t......tsLh.....GK.cshlhsop.Gus.hsht........t.sh-thh...hcshh.tahGhpsl....phhh...hpsht......s.pt.ppthppshp....phtp.l	........................................................................................................................plLllhups..........p.............p.s...s....t.ls....c.t...h....h....c..t....hpptt.............pp....................Vp.h...hD.....Lht...........................................................................t..p...........hsh.......tt-p....pp.lh....t.ADh..llhthPha.h...auhPshLK.t...alD..c...V....h...p..t..Gh.........sa..................t..u......s....t.sh.Lp.....GK...+.h.hl.h.hot....Gu.s...ptht.....................tt.sh..-.h.h..h....hc.t.h.h..t.a.hGhp.....l......tshh........hp.sht.......p...tpthtp.hhtth....h................................................................................................	0	410	843	1194
+2547	PF02441	Flavoprotein		Flavoprotein	Bateman A	anon	Pfam-B_1622 (release 5.4)	Family	This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD Swiss:P30197, which has been shown to be a flavoprotein that binds FMN [1]. This enzyme catalyses the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance [2]. dipicolinate synthase catalyses the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase Swiss:P33751 (EC:4.1.1.-) [3].	22.20	22.20	22.20	22.20	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.76	0.71	-4.47	143	8070	2009-01-15 18:05:59	2003-04-07 12:59:11	14	27	4696	49	2213	5827	2565	130.60	29	43.39	CHANGED	t+lllulTGusushh.uhcllctLt...cp...............hc..lp.llhopsA.pphlp.ts...............................thhpp..............................................lhsp............................tpshhspls..up...sDhhllsPsossTluKlAsGluDs.Llsps....................shst.h..........p+s.l..l.lsPshssh.....sshs	...................................................................................+llluloG.u.hu.Ahc..uscLlptLp...ct.........................................u......h-....V+.llhop...uA...pphlss.oh.................................tshstpt.....................................................................................................................................lhs-..............t..............................ssps...h..s..+.I.........s.......h...up..h.........sDhhllAP.sousolA+lApGhuDs..Llops..................................................shs..s..............................ppP..ll.lsPu.hsshhh.p.h...................................	0	675	1384	1855
+2548	PF00460	Flg_bb_rod	flg_bb_rod; 	Flagella basal body rod protein	Finn RD	anon	Prosite	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.77	0.72	-7.27	0.72	-4.19	16	12885	2009-01-15 18:05:59	2003-04-07 12:59:11	15	19	2264	1	2918	8471	1594	30.40	34	10.36	CHANGED	lhsuhouLsspppplcllusNlANss.TsGaK	..............h.huhoGhs..up.ppphsllusNlANs....s.TsGap..........	0	910	1827	2357
+2549	PF02120	Flg_hook		Flagellar hook-length control protein FliK	Mian N, Bateman A	anon	IPR001635	Domain	This is the C terminal domain of FliK. FliK controls the length of the flagellar hook by directly measuring the hook length as a molecular ruler [1].  This family also includes YscP of the Yersinia type III secretion system, and equivalent proteins in other pathogenic bacterial type III secretion systems.	29.80	29.80	29.80	29.90	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.28	0.72	-4.31	344	2733	2012-10-01 19:58:36	2003-04-07 12:59:11	11	7	2004	1	679	2315	298	85.60	22	18.28	CHANGED	tpphthtt.spshpphplpLsPscLGplplpl...phpss..p....lplpltsppspstphLcpshspL+ptLpp.......tGlpls.p..hsl..sttsttpt.t	......................tt.......hppstppsplcLcPtcLGplplpl...phsss..p.....h.plphhuppppspptLcpshspL+ppLsp.....pGlpls..p....hsl....stps.t...pt.............................	0	209	424	550
+2551	PF03963	FlgD		Flagellar hook capping protein - N-terminal region	Bateman A	anon	COG1843	Family	FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum [1]. It appears to act as a hook-capping protein to enable assembly of hook protein subunits [1].  FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerisation and also plays a role in determination of the correct hook length, with the help of the FliK protein [2].  This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallisation [3].	21.20	21.20	27.30	27.10	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.82	0.72	-3.91	135	2310	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	2042	0	554	1527	340	81.20	32	36.84	CHANGED	sssssss....ssssssstst.........................s.sssssss.......hspc..s.FLpLLlsQLpNQDPhsPhDsscasuQLAQFSslEthpphNsslpsl	................................................................................sshss..............tst.t.t.t................................stssssss...hsps..s.FLpLLlsQLpNQDPhs..P..h-s.......schhuQhAQhSsVp.thpphNsslps............	0	176	346	446
+2552	PF02107	FlgH		Flagellar L-ring protein	Mian N, Bateman A	anon	IPR000527	Family	\N	20.40	20.40	26.50	21.40	19.60	19.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.87	0.71	-4.71	159	1866	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	1593	0	422	1225	436	186.10	37	80.12	CHANGED	ts.stsss...GSla..psup..........ssLa..................pDpRAt.....plGDIlTVhlpEs.spAopsusosts+....sushsh....sh..sshh..................uhstts....................t..hshsu.sss...asGsGss..spsssLsuolossVscVLPNGNLhIpGcKplplNptschlploGlVRPcDIs......ssNolsSs+lA-ARIpYuGpGtls-spp.GWLp+hass.lhP	...........................ss....sssGSlapsup........psLF..................p.D.+Rsp.....plGDllTlllpEs..ss.ASKsussstuRsusssh....uh...ssls................shststs.....................s..hpssu.sss...Fs..GpGuu..spuNohsG..olTVsVspV.Ls.N.GNLhlpGEK.p.lt..lNpG..sEhI.RlSGlVcPcDIu.........ssNTVsSsplAD..ARIpYsGpGhl....s.-.u.Q.p.h.G.WLpRaF.s.l.P...................	0	107	239	330
+2553	PF02119	FlgI		Flagellar P-ring protein	Mian N, Bateman A	anon	IPR001782	Family	\N	25.30	25.30	25.40	26.90	25.00	24.80	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.01	0.70	-5.80	159	1904	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1613	0	429	1324	595	332.20	48	91.94	CHANGED	RIKDluslpGVRsNQLlGYGLVVGLsGTGDp....ps.sFTpQSlpsMLpphG..........l.sl...s.............ss............h.cs..KNVAAVhVTApLPsF.u+sGpplDVTVSSlG-AKSLcGGTLLhTPL+Gu...DGplYAlAQGslllGGhuup..Gts....uplphNhPTsGRIPsGAhVERpl......ss.sh.spt.sslpLsLcpsDFo..TApRlscuIN....pth................Gsss......ApulDusolpl..phPts.p.p..tVsFluplEsLpV.....ps.cssA+VVlNpRTGTlVhGpsV+ls.ssAVoHGsLTVpIs-s..tV...SQPs.sh..........u...............tGpTslsspoplslppp.....ssphhhl..ts.usoLs-lVcALNslGssPpDlluILpAlKsAGALpAEL.ll	.............................................................RI+DlsslpGVRpNpLlGYGLVVGLs.GTGDp....spo...PFTpQolsNMLpphG..........I..sl..Ps.......tss..................h..phKNVAAVMVTAsLPPF.u+tGQpIDVsVS..S..h...Gs..A..KSLRGGTLLhTPL..+Gs................DGpV.....YAl...AQGsllVGGh..uAp..........usu...SplpsNp.suGRIssGAhlEREl......................Ps.sF..ups...sslsL..pL..p..c..sDFo..sApplscsIN....phh........................G.ss..........ApAlDupolpVpsPpsss....s.............pVpFLAplpslpV.....ss..tstsAKVllNuRTGoVVhsppVplp.ssAVup...GsLoVslscp...p.V...SQPs.PF.....u......................sGpTsVsPpopIs.lppp.....suplh.l...ps.usoLsslV+ALNslGAoPtDLhuILQuh+pAGALcAcLplI......................................	0	119	250	339
+2554	PF04316	FlgM		Anti-sigma-28 factor, FlgM	Kerrison ND, Finn RD	anon	COG2747	Family	FlgM binds and inhibits the activity of the transcription factor sigma 28. Inhibition of sigma 28 prevents the expression of genes from flagellar transcriptional class 3, which include genes for the filament and chemotaxis.  Correctly assembled basal body-hook structures export FlgM, relieving inhibition of sigma 28 and allowing expression of class 3 genes. NMR studies show that free FlgM is mostly unfolded, which may facilitate its export. The C terminal half of FlgM adopts a tertiary structure when it binds to sigma 28.  All mutations in FlgM that prevent sigma 28 inhibition affect the C-terminal domain and is the region thought to constitute the binding domain. A minimal binding domain has been identified between Glu 64 and Arg 88 in Salmonella typhimurium (Swiss:P26477).  The N-terminal portion remains unstructured and may be necessary for recognition by the export machinery [1].	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.51	0.72	-4.03	135	1810	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1600	5	419	1076	250	64.00	28	67.14	CHANGED	DsVplSspuppl.pphptt.......................h..sstsslcpp.KVpplKpAIssGsYplDscclAcpllpht	....................................................................t.tVplSsttt...p.............................................h...ssss.-lsh-.+V..ptlKpAIps.GphplD..s..p+lAcsllp..h...............	1	135	267	349
+2555	PF05130	FlgN		FlgN protein	Bateman A	anon	COG3418	Family	This family includes the FlgN protein and export chaperone involved in flagellar synthesis [1].	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.80	0.71	-3.94	154	1850	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1595	3	413	1145	136	134.40	23	91.77	CHANGED	M..................ppLhphLp..pphphhpp....LhpllppEppsLtst..c.hp.tLpplspp...Kppllpplpphc..ppptphhtphsht....................h..........ppspltphhpp....lpphhp...chpphNphNspLlppphptspphlshlpsspst.......tsYsssGptps	...................................ptLhphlpp..shlpp....LtslhcpEpptLpts.....s.ss..pLptlscp...KspLlspLsth-....ppRp...ph.pphs.........................................................tpspltpthpp...............lpphhp....pl+phNppNu...hLlptphchspp.hlphlpstpps.......shYsspGp................................................	0	137	261	336
+2556	PF02465	FliD_N		Flagellar hook-associated protein 2 N-terminus	Mian N, Bateman A, Yeats C	anon	Yeats C	Family	The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria [2]. This alignment covers the N-terminal region of this family of proteins.	22.70	22.70	22.70	23.80	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.99	0.72	-3.63	191	2117	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	1839	0	481	1599	330	99.40	27	18.77	CHANGED	uSGlD..hssllspLhs.uEptsh...splppppsphpsploAauplpotLsshp.......s.shssL......tp.......s..s..sa.........ps..............pss...osS..ss.......shlos........ousus..As..sGoYsl.pVppLApupp	......................SulDhssllspLhp..A-ctsh....s....lspppsshsschoAa.usLcosLsshp........s.uhssL......sp..............s.....s......sa...............ss..............pps.......ooS....ss...........ss.h.os........o..s.s..us..Ah..sG..s.Y..sl.sVsQLApupp.....................................................................	0	160	302	395
+2557	PF02049	FliE		Flagellar hook-basal body complex protein FliE	Mian N, Bateman A	anon	IPR001624	Family	\N	22.40	22.40	23.10	22.90	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.97	0.72	-3.96	186	2295	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	2048	0	548	1400	351	98.30	29	92.64	CHANGED	tsh.............t..tssssssssssssssssssFushLppulspVsptQp...pusphspshtpG.c.ssslp-VMlAhp+AsluhphslpVRNKllpAYpEIMpMtl	..............................thhpshh..........t.sstspsssspsssuFushLpsu...l...s...cl...sppQp...sAcsts.pphthGc..sssLp-VMlshpKAslohphslpVRNKlVpAYpElMpMpl....	0	175	345	444
+2558	PF01706	FliG_C	FliG-C; 	FliG C-terminal domain	Bateman A	anon	[1]	Domain	FliG is a component of the flageller rotor, present in about 25 copies per flagellum.  This domain functions specifically in motor rotation.	23.00	23.00	23.30	23.80	22.20	22.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.03	0.72	-4.08	154	2393	2012-10-02 13:19:07	2003-04-07 12:59:11	11	8	2047	8	574	1470	494	109.70	39	32.55	CHANGED	lpslc.ppDsclApcI+cpMFsF-cl.hclcscslpplL+pls.scs...LslALKGAspp........lc-plhsNMSpRuuchlc--hcthGsV.+ls-VEpAQppIlphlRcLs-pGcI.ls	..................................pslc.chDs-LApcIp-pMFlFEsL.lc...lDD+uIQclLcEVs.s-s...LhlALKGAspt........L+-KhhpNM..SpRAA-..hlc--l.p.s.h.G..P.V.Rls-VEsAQ+pIltllR+Lu-sGEIhl.u.............	0	199	374	466
+2559	PF02108	FliH		Flagellar assembly protein FliH	Mian N, Bateman A	anon	IPR000563	Family	\N	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.18	0.71	-4.26	50	2270	2012-10-02 21:03:42	2003-04-07 12:59:11	11	6	1901	0	508	1633	260	133.70	22	54.20	CHANGED	ppt.hpplps....lhpplppslpph.......-pp....lpppLlpLslplu+pllt.pclpssPphllshlccsL.tthPhsspplplplpPsDhshlcpths.pthpthta.....plhsDsslspGGCplpossuplD.......uslpsRhcpl	.................................................................................................p....tphpt.lhsphppsh.pth...........ppp...........hppcLh.phulp.h....A....+pVlt..p....ph..p...s......s.s.p.t.l......l.p...h.l.p.psL...t...p..sh.....t....s......splpl+V...p....P....-.D....hp....hl...c...c....t...hs....t.....h.p...h...psa...................cl.hsD..ssL.....p........GuChlps-pGp.lD.......uslpsRhpp..........................	0	169	313	407
+2560	PF02050	FliJ		Flagellar FliJ protein	Mian N, Bateman A	anon	IPR000809	Family	\N	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.52	0.71	-4.07	147	1890	2012-10-01 21:16:01	2003-04-07 12:59:11	11	4	1724	1	454	1152	113	121.90	22	82.41	CHANGED	-cutppLsp...sppphpptppplptLpp.tppa..tpthpsph.......sphpphppalsplcpsItppppplpthcpplpptpppapptptchcphchLhp+ctpppppt.p+pEQ+hhDEhAhpta	.......................................................-pAtptLup...hp..pthpp....t....p....pp....Lp..Lhp....hpp....-a....ppphs....s.......sh...t..G.....h.....ss.....sphhs..hpp..Flp.......sLc.psIsppcp....plpphppcl.......-pspppapctppchpshppLp-+pppptthtps+t-QKthDEhAtpt.................	0	149	289	371
+2561	PF03748	FliL		Flagellar basal body-associated protein FliL	Bateman A	anon	COG1580	Family	This FliL protein controls the rotational direction of the flagella during chemotaxis [1]. FliL is a cytoplasmic membrane protein associated with the basal body [2].	23.80	23.80	23.80	23.90	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.16	0.72	-4.00	175	2462	2009-09-10 21:49:05	2003-04-07 12:59:11	9	6	1859	0	634	1614	444	101.40	24	62.20	CHANGED	shahsl....s...shslNlsss.....tt..+alp.lplslps....pspps.....hpplcp.....phP..h.lRssllthluspshp.....-lpss.pGpppL+pclhcpls.hl.............hpsp...............................lpsVhFosFllQ	.....................................ahsL....c...shslNLsss.....ttp..+hlp.lslsLpl..........pspts.........tsplpp.................thP........lRspllhhhup.....ps.h.p.....pLps..pG+.ppL+pclppplsphL.............stsp............................................lpcVLaTsFll.....................................	0	199	394	512
+2562	PF02154	FliM		Flagellar motor switch protein FliM	Mian N, Bateman A	anon	IPR001689	Family	\N	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.01	0.71	-4.64	7	1999	2012-10-01 19:50:22	2003-04-07 12:59:11	10	2	1927	3	493	1477	440	191.20	37	56.93	CHANGED	YDFppss+hS+EplpoLphla-pFARhhoouLpshLRphlclplsuVcphsYtEFlpSlPsPTsLslhphcPLcGsullplsPolsFshlDpLhGGcGpshs...csR-hTcIEppllppllchlLtsh+EAWpslhslcschschEsNPpFspIVs.PsEhllllsLclclGchpGhhNlClPahslEPIhphL	.............................................................YDhpp.cRls+-+.lpsL-hIpE+FARphphsLhshlRp.ss-lslsulc.hs.Y.p.EF.h.c......sLP.s.P.T.s.L...N....l....l..c......h.....c.....P.....L...+.....G...o.....u.....L.l.hhsPsLlFhhlDsLaG.G.cG.+......h........st.......-uRE..F..T.p.h.E....pc....l....lp....p....lLclsh....p....s....hp-AW....p.......s.l....h..s.....l...c.s....c...a.h..c.....s....E..h......s.s..p....a.....ss....I..so...Ps-.l.Vlh.ss.aclcl.G.s.h.s.GphsI.ClPashlEPlp-hL.................................................................	1	173	321	407
+2563	PF04347	FliO		Flagellar biosynthesis protein, FliO	Mifsud W	anon	COG3190	Family	FliO is an essential component of the flagellum-specific protein export apparatus [1]. It is an integral membrane protein. Its precise molecular function is unknown.	21.10	21.10	21.10	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.88	0.72	-3.94	108	1689	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1647	0	458	1182	140	88.50	26	54.79	CHANGED	AWLl+Rh......t....s..sss.tssstl+llushslGs+E+lllVcVssp.....llLGVTspplshLcp....l......................Pssssts.st.s...............................FuptLpphhpp	....................sWll+.Rh...............t...sstt..ssspsL+lluutuLGs+c+lllV..c.Vscp.....pllLG.VTs.s.pIslLcp.....L....................P.ps.tt.t.st............................................Ftphhpphh..........................................................................	0	155	289	373
+2564	PF00813	FliP		FliP family	Bateman A	anon	Pfam-B_1679 (release 2.1)	Family	\N	23.70	23.70	24.40	24.10	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.27	0.71	-4.60	141	3505	2009-01-15 18:05:59	2003-04-07 12:59:11	15	4	2195	0	652	2050	491	188.20	45	81.00	CHANGED	llTlLoLhPulllhhTSFTRIllVLulLRpALGhQQsPPNplLlGLALFLThFlMsPVhpphhpsuh.........pPhhstpl.....................shppAhpputtPh+pFMhcpT....cpp....-LthF.....hclu..........ptt.....sp.....shc-ss......hhlLlP..............AFhlSEL+sAFpIGFllalPFLlIDLVVASlLMuMGMMMlsPshISLPFKLlLFVLlDGWsLlltuLl	.................lThLollPslllhhTSFs+lllVhulLRsALGhQpsPPN.lLhGlALhLThFlMsPVhpclhppuh.....pP..h..h..ptpl.....................ohppAhc.c..utpPh+pFMl+pT....ccp.....-lthF.hclu..........................ptt...............p..s.csss...hhlLlP..............AFslSELKoAFpIGFhlalPFLlIDLVVuSlLMAhGMMMlsPshISLPFKLlLFVLlDGWsLlltuL..............................	0	200	389	513
+2565	PF02561	FliS		Flagellar protein FliS	Mian N, Bateman A	anon	COGs	Family	FliS is coded for by the FliD operon and is transcribed in conjunction with FliD and FliT, however this protein has no known function.	22.80	22.80	22.90	22.80	22.20	22.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.40	0.71	-4.26	6	2094	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1843	11	478	1234	391	123.60	32	91.09	CHANGED	hps.shpAYpQs....pVpTAoPtcLllMLY-cuIppLppAtc.....shpspchc+tscpI.+Ap-IIo.ELpsoLDhEpGtclupNLhulYsahh+pLhpANlcp-ssclspVhshh+sLp-AW+clhps.	............................................hs....uhpsYt....ps.......pl....h....s....A....SPppLlhMLa-GslptltpA+h........thp.pps.....htt+sttlsKAhsIlp.tLpssL-h..E....p..G.....u.....Elu..psL...tuLYsahh.pc..L..h..p..A.N..l....c..s.D...s...p.tl-EV..sllpslt-AWcph.....................................	0	163	309	394
+2566	PF01698	FLO_LFY		Floricaula / Leafy protein	Bashton M, Bateman A	anon	Pfam-B_1633 (release 4.1)	Family	This family consists of various plant development proteins which are homologues of floricaula (FLO)  and Leafy (LFY) proteins which are floral meristem identity proteins. Mutations in the sequences of these proteins affect  flower and leaf development.	20.20	20.20	20.20	20.70	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.53	0.70	-5.61	38	1844	2009-09-13 17:08:47	2003-04-07 12:59:11	11	5	1128	2	26	1110	0	134.20	55	97.00	CHANGED	MDP-s.F.....oAu.......hFK.WD....P+ssh.........s.Ps.....spl..pths.s.......sP...............s.ssht..hR...................uLE-LFpuYGVRYhTsAKIuELGFTssTLlsM+-EELDDMMsoLuclFRWDLLVGERYGIKAAVRAERRRL--...................................-..s+R+t..............ssDsss..sLDALSQE....G.LSEEsstp...h..uuuS..........................GGsu.sshthhshs......pc.........c++t....+p+++ptcc............................t.p..t.tttstts..........uGssGt....ERQREHPFIVTEPGEVARGKKNGLDYLFHLYEQCRcFLlQVQsIAKERGEKCPTKVTNQVFRYA.KKsGASYINKPKMRHYVHCYALHCLDEEuSNsLRRuaK.ERGENVGAWRQACYpPLVslAucpGWDIDulFNuHPRLuIWYVPTKLRQLCHhERussss	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FcLYEQCtcFL.pV.QplAKE+GEKCPTK.......VTNpVFRaA.KhsGA...............................................................................................................................................................	0	11	21	24
+2567	PF00624	Flocculin		Flocculin repeat	Bateman A	anon	Pfam-B_51 (release 2.1)	Repeat	This short repeat is rich in serine and threonine residues.	20.80	20.80	21.60	20.80	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.32	0.72	-4.12	173	1092	2009-01-15 18:05:59	2003-04-07 12:59:11	13	66	28	0	906	1281	2	43.60	44	27.58	CHANGED	tsso.Toho.sWos.shooTaSThhsThoss-G..pTTcTIYaVtTPh	...........h..to.Toho...sWTG.oh.ToThSTph.TThTGo-G....sT...sETlYhVcTPh.....	0	41	549	884
+2569	PF05202	Flp_C		Recombinase Flp protein	Studholme DJ, Finn RD	anon	DOMO:DM01865;	Family	\N	25.00	25.00	63.30	62.60	24.40	18.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.57	0.70	-5.16	8	18	2012-10-02 14:09:14	2003-04-07 12:59:11	7	2	15	12	3	31	0	194.40	52	58.85	CHANGED	uspluccloKllcs-.csIWpllsplhsoI-ppoppsop+AtYpalLlsTFhNCCRtSDLKNsDPpTFEllpN+aLG+llRAhVsETKTRpsRaIYFFPlp.G+sDPLlALa-aLppspPl.K..oRTScpcoc.Q-aQLLRDoLlpsYDRFluKcuspulFuIhpGPKSHLGRHLMuSYLSpsphschsosaGNWSAuccphpSsVARu+YsHs.ppslPscLFAFLSsYYtcsspGch......cLhssp	.h...s.th.+hh..p...hathh..hhp.hp..sh.sphps.hphhh.hohhNCsR.sDlKNhDPpoFcll.spaLGhhlpshVs-TKTph.RalYFassp.sthDPllhLcphhp.spPh.K..shossppsp.QcaQLL+-sLltsYs+hltKpss.ulFuIhpGPKSHlGRHLMsSaLSh+sLsELssllGNWS...DctuSuVARosYoHp.hsuIPDHhFAhlScYYshsP.uKphlsh..KDcs.P........	0	2	2	2
+2570	PF04964	Flp_Fap		Flp/Fap pilin component	Bateman A	anon	COG3847	Family	\N	23.90	23.90	23.90	23.90	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.16	0.72	-4.36	26	1017	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	521	0	401	913	41	46.60	34	72.55	CHANGED	Fh+-E.sGATAIEYGLIAuhIAlsll..ssssslu..ssLpstFsplusul	...........FhcDE.pGsTAIEY.GL.IAul.lAlsl..l......susss.lG....ssl.s.shF.sslsst................	0	120	223	315
+2571	PF03930	Flp_N	Flp;	Recombinase Flp protein N-terminus	Finn RD, Studholme, DJ	anon	DOMO:DM01865;	Domain	\N	25.00	25.00	25.20	42.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.67	0.72	-4.22	7	12	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	10	12	1	23	0	80.70	32	19.65	CHANGED	hss.....cchstlKhoTFhKYpppIppolpaDhsspsVpFcYHLKcsp-LpcsLccshtPhpFpl...pupKKssshhplhuuhc.+hp	............cpsstlKhuTFhKYpphIupoLpaDhsspslpFcYHhpcspcLpcsLcphhtshpFsl...tsp++.ssh.phhuuhphp................	0	1	1	1
+2572	PF02662	FlpD		Methyl-viologen-reducing hydrogenase, delta subunit	Bashton M, Bateman A	anon	COG1908	Family	This family consist of methyl-viologen-reducing hydrogenase, delta subunit / heterodisulphide reductase.  No specific functions have been assigned to this  subunit.  The aligned region corresponds to almost the entire delta chain sequence and contains 4 conserved cysteine residues.  However, in  two Archaeoglobus sequences this region corresponds to only the C-terminus of these proteins Swiss:O29030 and Swiss:029595.	22.30	22.30	22.90	23.90	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.23	0.71	-4.43	66	475	2009-09-12 00:14:48	2003-04-07 12:59:11	11	77	203	0	303	485	67	116.80	37	34.02	CHANGED	+IluFsCsasuYuuA..DhAG......ssRhpYPsslRlI+VhCoG+lsstallcAhpcG.ADGVhVsGC+hGD...CHah.pGNhpAccRhphl+chLpplGl-s-RlchtalSuuEup+asphlp-hscclccLG	.........................+IluFhCpasuYsu.A..DhAG......ssRhpYPss.lRlIRV.CoG+lsshallcAhpp..G.ADGVhlsGC+..G-...CHah.pGNh.........h...up+RhthlpphLpplGl-s-RlchpalSuuEut+asphlpchscplcpLG...................................	0	150	250	287
+2573	PF02947	Flt3_lig	flt3_lig; 	flt3 ligand 	Griffiths-Jones SR	anon	Structural domain	Domain	The flt3 ligand is a short chain cytokine with a 4 helical bundle fold.	25.00	25.00	36.60	29.60	17.80	16.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.84	0.71	-4.27	3	56	2012-10-02 01:28:15	2003-04-07 12:59:11	9	3	25	12	16	72	0	110.10	67	52.30	CHANGED	TPDCYFSHSPISSNFKVKFRELTDHLLKDYPVTVAVNLQDEKHCKALWSLFLAQRWIEQLKTVAGSKMQTLLEDVNTEIHFVTSCTFQPLPECLRFVQTNISHLLKDTCTQLLALKPCIGKACQNFSRCLEVQCQ	....sC.F.aSPI.SSsFt.phtpL...............SDYLLQD.YPVTVAoNLQD-cLCGAhW+LVLAQRWMtRLKTVAGScMptLLEtVNTEIHFVTpCAFQ.s.PsCLRFVQsNIS+LLQ-TspQLhALKPhIs+.......pNFSpCLELQCQ................	0	1	1	4
+2574	PF04772	Flu_B_M2		Influenza B matrix protein 2 (BM2)	Kerrison ND	anon	Pfam-B_2165 (release 7.6)	Family	M2 is synthesised in the late phase of infection and incorporated into the virion.  It may be phosphorylated in vivo.  The function of BM2 is unknown [1].	25.00	25.00	147.40	147.30	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.42	0.72	-4.00	4	501	2009-09-11 00:30:47	2003-04-07 12:59:11	7	1	487	16	0	121	0	108.60	95	99.99	CHANGED	MLEPFQILSICSFILSALHFMAWTIGHLsQIKRGVNhKIRI+sPNKETINREVSILRHsYQKEIQAKETMKElLSDNMEVLSDHIVIEGLSAEEIIKMGETVLEVEELp	MLEPFQILSICSFILSALHFMAWTIGHLNQIKRGVNMKIRIKGPNKETINREVSILRHSYQKEIQAKETMKEVLSDNMEVLSDHIlIEGLSAEEIIKMGETVLElEELH..	0	0	0	0
+2575	PF02942	Flu_B_NS1		Influenza B non-structural protein (NS1)	Bateman A	anon	Pfam-B_198 (Release 6.4)	Family	A specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 Swiss:Q64339 to its target proteins both in vitro and in infected cells. Of the several hundred proteins induced by interferon (IFN) alpha/beta, the ubiquitin-like ISG15 protein is one of the most predominant. Influenza A virus employs a different strategy: its NS1 protein does not bind the ISG15 protein, but little or no ISG15 protein is produced during infection [1].	25.00	25.00	246.10	245.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.67	0.70	-5.47	5	839	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	785	7	0	395	0	243.30	96	87.75	CHANGED	MADNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPEuKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYClKNPSNSNCPNCsWADYPPTPGKYLDDIEEEPENVDDPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDIRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERF	...MAsNMTTTQIEVGPGATNATINFEAGILECYERLSWQRALDYPGQDRLNRLKRKLESRIKTHNKSEPESKRMSLEERKAIGVKMMKVLLFMNPSAGIEGFEPYCMKSSSNSNCsKYNWTDYPSTPGRCLDDIEE.EPEDVDGPTEIVLRDMNNKDARQKIKEEVNTQKEGKFRLTIKRDMRNVLSLRVLVNGTFLKHPNGYKSLSTLHRLNAYDQSGRLVAKLVATDDLTVEDEEDGHRILNSLFERL........	0	0	0	0
+2576	PF03506	Flu_C_NS1		Influenza C non-structural protein (NS1)	Bateman A	anon	Pfam-B_980 (release 7.0)	Family	The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment  encodes a 286 amino acid  non-structural protein NS1 [2]. This protein contains 6 conserved cysteines that may be functionally important, perhaps binding to a metal ion.	25.00	25.00	114.50	114.10	18.70	18.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.02	0.71	-4.50	2	111	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	80	0	0	66	0	146.10	98	64.31	CHANGED	GELLFNGTILQAESsTMT.ASVEMKGKK.PIDFsPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIA+QVAGIETGIRKCFRCIKSGFVMATDEISLhILpSIKSGAQLDPYW	GELLFNGTILQAESPTMTPASVEMKGKKhPIDFAPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIARQVAGIETGIRKCFRCIKSGFVMATDEISLTILRSIKSGAQLDPYW	0	0	0	0
+2577	PF03555	Flu_C_NS2		Influenza C non-structural protein (NS2)	Bateman A	anon	Pfam-B_346 (release 7.0)	Family	The influenza C virus genome consists of seven single-stranded RNA segments. The shortest RNA segment  encodes a 286 amino acid  non-structural protein NS1 Pfam:PF03506 as well as the NS2 protein. The NS2 protein is only about 60 amino acids in length and of unknown function.	25.00	25.00	133.60	133.10	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.00	0.72	-4.05	2	203	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	80	0	0	112	0	56.80	99	27.82	CHANGED	VKSTNLMAFVATKMLERQEDLDTCTEMQlEKMKsSTKARL+TESSFAPRTWEDAIKD	VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKD.	0	0	0	0
+2578	PF00598	Flu_M1		Influenza Matrix protein (M1)	Bateman A	anon	Bateman A	Domain	This protein forms a continuous shell on the inner side of the lipid bilayer, but its function is unclear.	20.90	20.90	21.10	23.00	20.20	18.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.86	0.71	-4.83	2	22622	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	22201	27	0	3071	0	152.20	94	61.75	CHANGED	SLhs-s.sYlLSlh.sG.hKAElAp+LcshFuGKphDL-uhhEWlKs+.hLoslpKullGhshshhhPp-p..p+RRFlppsLsG.Gssss.hcthlhh.RKh+RploFHtAhEIA.uapuuALh.ChhlhY.phGshohpVhLGhlCAhCEp.Asp	..........SLLTEVETYVLSIlPSGPLKAEIAQRLEDVFAGKNTDLEALMEWLKTRPILSPLTKGILGFVFTLTVPSERGLQRRRFVQNALNGNGDPNN.MDRAVKLYRKLKREITFHGAKEVALSYSoGALASCMGLIYNRMGTVTTEVAFGLVCATCEQIADS.......	1	0	0	0
+2579	PF00599	Flu_M2		Influenza Matrix protein (M2)	Bateman A	anon	Bateman A	Family	This protein spans the viral membrane with an extracellular amino-terminus external and a cytoplasmic carboxy-terminus.	25.00	25.00	25.50	25.50	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.24	0.72	-4.20	2	21616	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	21060	57	0	4083	0	92.50	89	100.00	CHANGED	MSLLTEVETPh+stWECRCsDSSD.LVshASIhGILHLILWIhDRLFFKChYRRh+aGLKRGPuTuGlPESMREEYRQEQQSsVsVDsGHFVNIELE	....MSLLTEVET...PhRNEWECRCsDSSDPLVlAAsIIGILHLILWILDRLFFK...CIYRRFK..YGLKRGPSTEGVPESMREEYRQEQQsAVDsDDGHFVsIELE.............	0	0	0	0
+2580	PF00506	Flu_NP	flu_virus_nuc;	Influenza virus nucleoprotein	Finn RD	anon	Pfam-B_10 (release 1.0)	Family	\N	25.00	25.00	27.70	26.80	16.80	16.10	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.60	0.70	-6.01	3	18503	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	18183	20	0	6541	0	474.40	89	99.75	CHANGED	MAs.SsKR....S.EphpTuuE.......QpRQTPTEIRKSVupMVsclGEFYIQMCsElGLNsDhEtpLIQNuIAIERhlLuAsD-K+sEap+EKsAR-spcucushDscKTGGslYKRsRDGKsIpapslllLasKEEI+pIaK.oshGsD......AsuGLsHlMIaHSNLNDlsYQRoRALsRsGhDPcLhSLhQGSTLPRRSGAsGsAlKGlGTLVAEAIRhI......KRGlsDRshLR...ut+T+oAYERhhpsLKsKspsusQRALsDQVlcSRNPGsA-IEDLslLARSuLlLRPSVAsKssLPhClYhhA+lothDFpsEtYShVGh-AFcLaNhAp......sFSllRsNDDs....cDKSQLlaMACFGAAYEDLRVlSAlsGTclKPRupLKs+GF+VsusEpVETMsSuLLplRhpaWAshTRSGGNpssscuuuGQISsSPVFAVERsIsh-+QsVcchLohNlEGR-uDs+ssLlKMMc-uhu....pKoEssuFlG+uMF-LSDccKTNPI..sF+poscsFFFttDsAEDYDs	.....................................................................MASQGTKR....SYEQMETGGE.........RQNATEIRASVGRMlGGIGRFYIQMCTELKLS.DYEGRLIQNSITIERMVLSAFDERRNKYLEEHPS.......AGKDPKKTGGPIYRR.hDGKWMRE...LILYDKEEIRRIWRQANNGED......ATA..G.....LTHlMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMI......KRGINDRNFWRGENGRRTRlAYER.MCNILKGKFQTAAQR.AMMDQVRESRNPGNAEIEDLIFLARS..ALILRGSVAHKSCLPACVYGLAVASGYDFEREGYSLVGID..PF.+LL.QNSQ......VaSLIRPNENP....AHKS...QLVWMACHSAAFEDLRVSSFIRGT+VlPRGpLSTRGVQIASNENMEsMDSsTLELRSRYWAIRTRSGGNTNQQRASAGQISVQPTFSVQRNLPFERATlMAAFTGNTEGRTSDMRTEIIRMMEuA.......+PEDVSFQGRGVFELSDEKATNPIVPSFDMSNEGSYFFGDNAEEYDs.....................................	0	0	0	0
+2581	PF00600	Flu_NS1		Influenza non-structural protein (NS1)	Bateman A	anon	Bateman A	Family	NS1 is a homodimeric RNA-binding protein that is required for viral replication. NS1 binds polyA tails of mRNA keeping them in the nucleus. NS1 inhibits pre-mRNA splicing by tightly binding to a specific stem-bulge of U6 snRNA.	25.00	25.00	30.00	30.00	22.90	20.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.19	0.70	-5.20	3	18530	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	18330	77	0	6565	0	214.70	83	95.82	CHANGED	MDSNTVSSFQVDCFLWHIRKplADQ-MGDAPFLDRLRRDQKSLKGRGSTLGLDIEsATRsGKQIVERILKEESDEsLKhTIASuPASRYLTDMTIEEMSR-WYMLMP+QKlTGuLhIRMDQAIMDK+ITLKANFSVlFD+LETLlLLRAFT-DGAIVGEISPIPSLPGHTNEDVKNAIGILIGGLEWNDNTVRlSEsLQRFAWRsSDENGGPPLoPK	...MDSN.TVSSFQVDCFLWHlRKRFADQ-LGDAPFLDRLRRDQKSL+GRGsTLGLDIETATpsGKQIVE+ILKEESDEALKMTlASsPASRYLTDMTLEEMSRDWFMLMPKQKVt.GsLClRMDQAIM-KNIlLKANFSVIFDRLETLILLRAFTEEGAIVGEISPLPSLPGHT.EDVKNA.IGVLIGGLEWNDNTVRVSEslQRFAWRSssEsGRPPLPP................................	0	0	0	0
+2582	PF00601	Flu_NS2		Influenza non-structural protein (NS2)	Bateman A	anon	Bateman A	Family	NS2 may play a role in promoting normal replication of the genomic RNAs by preventing the replication of short-length RNA species [1]. 	25.90	25.90	26.00	26.70	24.60	25.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.97	0.72	-3.78	4	18368	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	18223	2	0	3232	0	92.00	84	77.49	CHANGED	LNGMITQFEpLKLYRDSLGEuVMRhGDLHSLQsRNupWREpLuQKFEEIRWLItEsRphLphTENSFEQITFhQALQLLhEVEpEIRTFSFQLI	....LNGMITQFESLKlYRDSLGEAVMRMGDLH.LQsRNuKWREQLuQKFEEIRWLIEEVRHRLKtTENSFEQITFMQALQLLLEVEQEIRTFSFQLI....	0	0	0	0
+2583	PF00603	Flu_PA		Influenza RNA-dependent RNA polymerase subunit PA	Bateman A	anon	Bateman A	Family	\N	23.00	23.00	23.00	26.40	22.30	22.90	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-13.03	0.70	-6.50	4	18248	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	17904	29	0	9139	0	661.40	91	97.25	CHANGED	hsEhuEDhhhpss....+lhpIChHhpVChhhSDhcalscpGps...............pa-lIEGpcRshAh.l.pplCpppslEhP.+aLsDLaDhccppFlElGlT+chsD.Ya.pKhpKl.ussh+lhlFSasG.-hspss-hsLcEEp+tRIhohLsphtp.lspcNLapplhts-stEptI-..FclGpThpcL..RDpS...lP.sFpshEth+sYh-th..sPR.tlEsplupMpsplph..c.hchsphR.ItL.....-GP.sPapuhhLhtDuhhls.ls-PppcptuI.hh-.....phhasps-..hI+.p-Ks.susahh.....Wpplhuslpshtp......o.shp+sspscaAhG.shs.cKl.....ppsshsspshKQtEsclPEhpSlssWlpsEhshhpp.o-.stWl-LsEhsssss.lEtlApthpchahs.lsts+suphhhKhllhsTuLhspspsshu+hpllPIhsRshsccu........pphspLaGhslKGpSHL+pDTDsssllohEFShpDPcl-..Ka.KYoVFclGphh........VtG+phshaLYsRssuhSKIKhcWh.chRRCLlQohpphEsll.pESuhpppshsccsh.....Nc.pha.IGpppGtl.ttoltcslRslLspphhhslYsssQLEGFsAEpR+LLhslpAh+-p+p...PasFc.EGhh-tIEEClINNPhVlh.AphaNphlh.shc	.................MKEYGEDPKIETN....KFAAICTHLEVCFMYSDFHFIDERGESIIVESGD.PNALLKHRFEIIEGRDRTMAWTVVNSICNTTGVEKP.KFLPDLYDYKENRFIEIGVTRREVH.IYYLEKANKIKSEKTH.IHIFSFTGEEMATKADYTLDEE.SRARIKTRLFTIRQEMASRGLWDSFRQSER.GEE.TIEE+FEITGTMRRL..ADQS...LPPNFSSLENFRAYVDGF..EPNGCIEGKLSQMSKEVNA+IEPFLKTTPRPLRL....P-GPP..CpQRSKF.LLMDALKLS.IEDPS.HEGEGIPLYDAIKCMKTFFGWKEPNIVKPHEKGINPNYLL....AWKQVLAELQDIENEEK.IP+TKNMKKTSQLKWALGENMAPEKV......DF-DCK...DVuDLKQYDSDEPE.RSLASWIQ....sEFNKACELTD..SSWIELDEIGEDVAPIEHIASMRRNYFTA.EVSHCRATEYIMKGVYINTALLNASC...AAMDDFQLIPMISKCRTKEG........RRKTNLYGFIIKGRSHLRNDTD.VVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLR....TAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFF....ENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLE...PGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHAL.K.........................................	0	0	0	0
+2584	PF00602	Flu_PB1		Influenza RNA-dependent RNA polymerase subunit PB1	Bateman A	anon	Bateman A	Family	Two GTP binding sites exist in this protein [1].	20.70	20.70	20.80	21.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	740	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-13.07	0.70	-6.81	5	18462	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	18111	8	0	8861	0	698.20	94	98.09	CHANGED	M-l.NPtLLFlc...VssQssISTTYPYTGPPPhSHGTuTtYTL-TVpRTacYSc.KuKpppscVsGss+l.cssNssL-EDNhsEPSGsAclDsVLtLhcph--ca.PGhFc+ustEAhEclhppcas+LTcGRQTaDWTssRNQPAATALpsTI-sh+pN.LsuscGsoMl-alcclhEsLD.+pElcFp..ssKshcR....+hcDppotthlp..cKphsKtcs+Is+cEYlpRALTLNTMsKDuERGKLcRRAIATPGM.lRGFVhlVEslA+sICEpLcpSGLPVGGNEKKAKLuosVcclhsp.ssuplosTlTGDNoKWNEChsP-saLAMlshIT+DuPpWh+-lhSIAPllFSNKhA+LGcGlhhpsKTp+pcslI+A-sluchc.ctFNEcp+stIcclEshl.p-GsspLosGMhMGM....FNMLSTVLGVSsLuhspcclsspthhWDGLQSSDDFlLFssA+Na-shppsl-cFh+lCKLlGINMSpKKS.YlstTGlFEFTSMFaRcGFVuNhAMELPSFs.suGlNESuDhulGholIKNNMINNsLuPuTAphAL+IFIp-YRaTY+sH.hDoclpsRRhKhLKchhcpppuKDGLLluDGGPslaNl+sLHIPElsLKa-..LMDE-Y+sRlhNPpNPFsu+spIE..cpsslFcAHGPl.+shEp-AVuoTHSacT+RNRolLNTcpRshlt-EQpYQKsCNlFEcsFsSuohRsPlG.tShhEAhtcRLc....cu+LctEuGRlpc-Ea-c	............................................MDV.NPTLL.FLK...VPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYSE.KGKWTTNTETGAPQL.NPIDGPLPEDN..EPSGYAQTDCVLEAMAFLEESH.PGIFENSCLETMEVVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVFRSNGLTANESGRLIDFLKDVMESMD.KEEhEIT..THFQRKR.....RVRDNMTKKMVT...QR.T..I...GKKKQRLNKRuYLIR.....ALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVETLARSICEK..LE..QSGLPVGGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNEN..QNPRMFLAMIT.....Y.............ITR........N..QPEWFRNlLSIAPIMFSNKMARLGKGYMFESKpMKLRTQIPAEMLAsIDLKYFNEST+KKIEKIR...PLL.IDGTASLSPGMMMGM....FNMLSTVLGVSILNLGQK+YTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKKS.YIN+TGTFEFTSFFYRYGFVANFSMELPSFG.VSGINESADMSIGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLW-QT.pSKAGLLVSDGGPNLY...NIRNLHIPEVCLKWE.....LMDEDYpGRLCNPLNPFVSHKEIESVNNAVVMPAHGPA.KSMEYDAVATTHSWIPKRNRSILNTSQRGILED.E.QMYQKCCNLFEKFFPS....S....SYRRPVGISSMVEAMVSRAR...ID.A.RIDFESGRIKKEEFu.......................	0	0	0	0
+2585	PF00604	Flu_PB2		Influenza RNA-dependent RNA polymerase subunit PB2	Bateman A	anon	Bateman A	Family	PB2 can bind 5' end cap structure of RNA [1].	25.00	25.00	37.80	37.70	17.90	16.50	hmmbuild  -o /dev/null HMM SEED	759	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-13.23	0.70	-6.68	6	18433	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	18053	21	0	9733	0	710.70	92	99.89	CHANGED	MERIKELRsLMSQSRTRpILTpTTVDHMAIIKKYTSGRQEKNPuLRMKWMMAMKYPITADKRIhEhIPERNEQGQT.LWS+TsDAGS.DRVMVSPLAVTWWNRNGPsusThHYPK.VYKTYFEKVERLKcGTFGPVHFRNQlKIRRRVDlNPGHADLSuKEAQDVIMEVVFPNEVGAplLTSESQLpITKEKKEELQ-CKIuPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGsCWEQhYsPGGEVRNDDlDQSLIIAARsIVRRAsVSs.DPLuSLLEMCHST..QIGGs..RMVDIL+QNPTEEQAVDICKAAMGL+ISSSFSFGGFTFKRTSGSSVKREEElLTGNLQTLKIclHEGYEEFThVGK+ATAILRKATRRLlQLIlSG+DEQSIAEAIIVAMVFSQ-DCMIKAVRGDLNFlN...RANQRLNPMHQLLRHFQK...DAKlLFQNWGIEpIDNlMGMhGILPDMTPSTEhSLRGVRlSKhGVDEYSSTERlVVSIDRFLRVRDQpGNVLLSPEEVSETQGTEKLTITYSSSMMWElNGsESlLVNTYQWII+NWET.....VKIQWSQDPThLYNKhEFEPFQSLlPKAtRGQYSGFVRTLFQQMRDVLGTFDTsQIIKLLPFAAAPPKQSRM..QFSSLTVNVRGSGMRIL.VRGNSPVFNYNKsTKRLTlLGKDAGsLscDPDEGTs.GlESAVLRGFLILGKED+RYGPALSIsELusLAKGEKANVLIGQGDVVLVMKRKRsSSILTDSQTATKRIRMAlN	....................MERIKELRsLMSQSRTREILTKTTVDHMAIIKKYTSGRQEKNPALRMKWMMAMKYPITADKRIhEMIPERNEQGQT.LWSKTNDAGS.DRVMVSPLAVTWW..NRNGPTTSTVHYPK.VYKTYFEKVERLKHGTFGP..VHFRNQVKIRRRVDlNP.GHADLSAKEAQDVIMEVVFPNEVGARIL...TSESQLTITKEKKEELQDCKIA.PLMV..AYMLERELV.RKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRAsVSA.DPLASLLEMCHST..QIGGl..RMVDILRQNPTEEQAVDICKAAMGLRISSSFS.FGGFTFKRTSGSSVK+EEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVN...RANQRLNPMHQLLRHFQK...DAKVLFQNWGIEsIDNVMGMIGILPDMTPSTEMSLRGIRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWEs.....VKIQWSQDPTMLYNKMEFEPFQSLVPKAsRuQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRM..QFSSLTVNVRGSGMRIL.VRGNSPVFNYNKATKRLTV.LGKDAG..ALTEDPDEGTu.GVESAVLRGFLILG.KEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTATKRIRMAIN...........................................................................	0	0	0	0
+2586	PF03069	FmdA_AmdA		Acetamidase/Formamidase family	Bateman A	anon	Pfam-B_2541 (release 6.4)	Family	This family includes amidohydrolases of formamide EC:3.5.1.49 and acetamide. Swiss:Q50228 forms a homotrimer suggesting all the members of this family also do.	19.50	19.50	20.10	19.50	18.90	19.40	hmmbuild  -o /dev/null HMM SEED	369	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.13	0.70	-5.76	8	1881	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	808	40	759	1832	361	191.80	18	81.87	CHANGED	sllslD+sK..hcpss.hHNRWHP-lsssApV+PGEpl+lEshDAhGGQIpss-u...usDlcslDLoplH.LoGPltVcG.....AcPGDlLhV-IhDh.slc.......sct...GasGhFs+tsGuGFLsD+..ascstKslW-acGhassScplPGVRaPGhsasGVIG.sAPSc-lLsphscRE.t.ltpss..s..hs..Ppsp.th...........tlAsEuhRTlPsR.-sGGNhDlKslo+GS+lahPVFVEGAhLShGDlHaoQGDGElshs.AIEMuGplsl+lclIKsG.lcphslcs........Pha..u.l.cPpap..calhhpGluVD-uh.+pthhssshAh+puhLNsIsahc+aGYsstQshlllSsssspu....hVs.ssusssstlP.stIFpps	............................................................................tt..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sG..D...h..Gs.hhh.l...su.h.hGs.+h..u.uc.s....sh-..........h.h..h..................................................................................................................................................................................................................................s...................................................................................................................	0	226	478	623
+2587	PF01070	FMN_dh		FMN-dependent dehydrogenase	Finn RD, Bateman A	anon	Pfam-B_829 (release 3.0)	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.68	0.70	-5.61	180	7189	2012-10-03 05:58:16	2003-04-07 12:59:11	13	28	3457	189	2186	12550	8912	259.10	23	86.79	CHANGED	A.+cpLPth..sasYlsuGAssEhThpp.NpsAFpchpltPRsL..psls...ph..chs..sslh.....GpphshPlhlAPsGhptLhas.c..GEl....shA.+AAsptGl..shslSohusssl.....E-l......up.s..............ss........ssh..WFQLYh...pDcshsppllcR.Ac..sAGhcuLllTVDsPshGpRc..p-hRssh....th....P.th.......hthh.phh.ts..............................tt................................................................tssth.tthht..h...p.....ss.lsW.cc.lphLRp..t.h..shPlllKGl...hss-DAttAhchG..sD.GIlVSNHGGRQ...........................LDuususl-sLPpl.sp..sl.s...............................sc.....htlhlDGGlRpGsDllKALALGAcuVhlGRshlaGLA.ssGptGVp+slclLpsElctsMsLhGssslscl...st.sh.lpt	...............................................................................................................................................................................................................................................................................................................................ts.hp.ph.hh.phl........hs.h.p...p.h........s..h..p..sph....h.................s........p..h........t..hPhh..hssh.s.....h......t...t....h......ht...........p....hph...........thAp....s.st..t..h.....s..h....h......hh.u......o.s.....h..h.........p..h..........................................................................h.h...h...................t..................th.h.........tt...h.............t...........h........s.l...h..p.h.s...........................................................................................................................................................................................................................................hsh....pp..lt..ltp................h......t.....h.....P.hll..K...t.....l...................hs.......c...s........s.t............h.....h....p.......h....G.......s....p.....u.l......l.......S....s.....+....G.....G......p....p........................................................................h...D..h.....s.........s....s..............h......p...s........L..........t.l...hp....h...t..........................................................tp........h.l.hh.s.uG.lRpG.Dl.h+....sl.A.L.G.Ac....hshlu.Rshl....h.ul............t....h.t.............G................t............u..l.....p.h...l.p.h...h.t...t...-hchhMthhGspslt..plp......h................................................................................	0	652	1304	1811
+2588	PF00743	FMO-like		Flavin-binding monooxygenase-like	Bateman A	anon	Pfam-B_437 (release 2.1)	Family	This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	532	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.62	0.70	-6.31	5	2951	2012-10-10 17:06:42	2003-04-07 12:59:11	14	45	679	107	1914	7810	2768	277.00	19	77.52	CHANGED	AKKVAVIGAGVSGLuSIKCCLEEGLEPTCFERS-DIGGLWRFoEssEEGRASIYKSVloNoSKEMSCFSDFPFPEDYPNFMHNSKlLEYl+hFAK+FDLLKYIQFKTTVCSVsK+PDFSoSGQWEVVTE+EGKpcSAVFDAVMVCTGHHlNPHLPLESFPGIc+FKGQYFHSR-YKcP-uFpGKRVLVIGlGNSGuDIAVELS+TAcQVFLSTRsGSWVlSRluDsGYPWDMllsTRFsoFL+NlLPoslSsWlhE+QlNcRFNHENYGLpPcc+shtKEPllNDELPuRILsGtVpVKssVKEFTETSAIFEDGTlEEsIDlVIFATGYTFuFPFLEESlVKlccNclSLYKtVFPPpLEKPTLAIIGLIQPLGSIlPTsELQARWAsRVFKGLC+LPSppcMMpEIsc+pEc+hKhFG.spocslQoDYIsYMDELAsaIGAKPNLhSLhLTDP+LAlcVFFGPCoPYQYRLsGPGKW-GARNAILTQWDRoLKPLKTRlVpcSssPsuuF.hLKlFulslLLlAlFLlht	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s................t.....h.........................h.......................................................t..............................................a.....................t.......................h......tY..h.t..h..s.....t.......t.....h.....t.....h......................h.......h....t....t.........l..............................h..................................................................................................................................................................h..............................l..................................................................t...............................................................................h................p......h........l...........h..........h..s....s......G...........................s..............h........P........................................h..............s.....................t.....a....................s....t.........h..H.................u........................a........p...........t......s........t...................h..........t........s.....p..........p..........lh..ll.G....u..S.u.....-...l....s........p...h.......................s.....t.....t.....................................h.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.......h....................t.....t.......................................................D.....lhhsT.....Ga.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................thh...................................................................................................................................................................................................................................................	0	525	1056	1588
+2589	PF00039	fn1		Fibronectin type I domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.70	20.70	20.80	21.30	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.42	0.72	-4.15	20	1772	2009-01-15 18:05:59	2003-04-07 12:59:11	13	57	52	70	393	1849	0	38.10	42	17.20	CHANGED	ChD.posspYplG.-pWpR.tp..Gthhp.CpChGtGpGchpC	..ChD.s..GspY.pl.G.-pWc+.tp..G.hhhp.CTCh.Gs..G.pGcapC.....	0	20	53	138
+2590	PF00040	fn2		Fibronectin type II domain	Sonnhammer ELL	anon	Prosite	Domain	\N	22.20	22.20	23.60	22.60	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.60	0.72	-3.95	111	1582	2009-01-15 18:05:59	2003-04-07 12:59:11	14	126	87	45	677	1460	22	41.30	49	6.08	CHANGED	ChFPFhapGppYpsCTscGcs.tthW..CuTT.ssYDpDpcWua..C	...ChFPFhapGcpYpsC...Ts...cG.R......p.D.....uhhW..CuTT.tsYD...p...D...p...+...aGFC.................	0	92	123	281
+2591	PF00041	fn3		Fibronectin type III domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.73	0.72	-3.85	106	58087	2012-10-03 16:25:20	2003-04-07 12:59:11	16	3078	1986	274	27544	50190	2367	84.30	20	23.88	CHANGED	ssP.pslphpsh...sssslplsWpss.....suslssYplph....ptsssp...........hpphs...lsss....p...phslpsL.pPsspYphpVt.Ahsst.....t.S	....................................................P.tsl..p..h..p..sh......ss.s.....o...l..p..l......s...W.....p..s.........P................t..................s..........u...........t........l............p...........s...........Y..h.......l...p......h......ppt.sstt...........................................htp.h.s............h.s..s.s..................pp....p..h.p.....l.....s......s.....L...p.........s...s..........s.p.Y.....p....h.p..Vt..A.h.st.tG...u.............................................	0	7000	9544	17225
+2592	PF02986	Fn_bind		Fibronectin binding repeat	Griffiths-Jones SR, Schwarz-Linek U	anon	Pfam-B_2661 (release 6.4)	Repeat	The ability of bacteria to bind fibronectin is thought to enable the colonisation of wound tissue and blood clots.  The fibronectin binding repeat is found in bacterial fibronectin binding proteins and serum opacity factor.  Bacterial fibronectin binding proteins are surface proteins that covalently link to the bacterial cell wall, mediate adherence of the bacteria to host cells [2] and trigger the fibronectin/integrin-mediated uptake of bacteria by host cells [3]. Each fibronectin binding repeat is an array of short motifs that bind to fibronectin type I domains [4]. Fibronectin binding repeats are natively unfolded in the absence of fibronectin and are thought to adopt a well-defined conformation (tandem beta-zipper) upon binding [5].	21.20	21.20	21.40	21.40	19.50	21.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.85	0.72	-4.44	34	1694	2009-01-15 18:05:59	2003-04-07 12:59:11	9	50	190	4	23	1338	0	37.00	43	15.06	CHANGED	pslDhsE..DT.....suhS..Gpssss...oh.EDT+...Pp..hh.hGGp	......N.VDh-.Do....lPplp...Gp..Ncss..pshEEDTpt..sc..h...GG...........	0	6	6	14
+2593	PF03274	Foamy_BEL		Foamy virus BEL 1/2 protein	Mifsud W	anon	Pfam-B_4337 (release 6.5)	Family	\N	21.50	21.50	21.70	54.70	20.20	21.40	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.79	0.70	-5.12	6	21	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	8	0	0	35	0	218.60	34	59.84	CHANGED	hshsEhE.slu..ssEN....Ptc.+hhpp..pssst-spsVoYH.uYK-pEDpps.cI.KhcDWlPsP-cM.SKplCppLILssLYsupKAtEllp..................hsasVpW..EQScssPshFtl...pYpChhCpslha-PMPlha....DscsclWhKht.LRuslGSlVashc+Hhpp...Cpu.VcP.pp..pGps.......t+PRhRssPshRa.+hhtEasssR.+coK.hlsppspuHp......SsGDshAhts	...................shsEhE.slu..stpN....Ptcs+hhpp......tcspploaH.uY+EhE-pps.pl.KLpDWlPsP-cM.SKpls...........pp.lhshLhps.Kst-.lp..................hPhsssW..pQscssPshFtl....Ypshhspshha-Ph.hha....DPpschahthphLhsslGplshphaKphps...Cpu.lcP.ss..pups.........scPRs+ssPsLpa.+hhhctshsRp+cp+.hlh+hspuHc.ss...SsuDhhAhp...........	0	0	0	0
+2594	PF03408	Foamy_virus_ENV		Foamy virus envelope protein  	Finn RD	anon	Pfam-B_4411 (release 6.6)	Family	Expression of the envelope (Env) glycoprotein is essential for viral  particle egress.  This feature is unique to the Spumavirinae, a  subclass of the Retroviridae.	20.10	20.10	20.40	24.00	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	981	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.94	0.70	-13.61	0.70	-7.02	7	89	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	14	0	0	86	1	583.90	52	99.33	CHANGED	MTLpQWl.W+thppspphLpshssl..pphp.slh-hpt-EhlPh+h.RhKYhhYsCCATSTRlhsWlhhlClLL.lVhlSshlTlhRlQWppsIpV.GPVlsWNlopptshpshpst+luRphRs.H.t.p.VpVNhTSIPQGVaapPHPcPIIhKERVLGLSQVlMIsS-sIApstNLspEsKsLLs-MINEEhpsLusshlsFElPLGDP+sQ-QYIH++CaQcFAHCYlV+Ytss+sWPocplItDQCPLPsh.ass.tYphQsIWDYYl....htPpsWsscsh..YGp....ARlGuaYlPp..hppshoHVlFCSDQLYucWYshppo.pppEcLhhpKLhN..Lspts.upLKcRALPssWsspGputLFR-lNsLDhCs+PEAVhLLNpoYYsaSLWEGDCshpppsIoph.spC+sa.pp...pphHPYACRFWR....pp.tp-EhKChssEp..+CLYaPpaDosEtt.DFGaLAY.ssFPSPICIcppslp-.cYcV.SLYtEChppucpYGIcsVl.tLcshLs.sGhsls-hPsuRAFssLss.paPsoY.NhTpp.pppuC....s+RpRRSl..sNac+LpohGhuLssAlpTLSpISDlNDEpLtpGlaLLRDHlVTLMEAsLHDISlhEuMhulQHlHTHLspLKshLLtpRIDWoaIpSsWIQpQLQto--.MKlIRRTARSlsYhVpQTpsosTuTuWEIGIYYEllIPK+IYLsNWplhNlGHLl+sAGaLT+VplpHPYEIlNpECppppYLHLE-ChcQDYlIC-.V..VpPCGNsTs.SDCPVhActlKsPYlplpPLKNGSYLVLoSpTDCuIPsYlPslVTVN-TlcCFGhpFK+PLhuEp+s.sapPplPpLcLRLPHLlGIIAKlKulcIEVTST.EsIKDQIcRAKAELLRLDlHEGDaPsWlpQLusATcDVWPAAAsslpuIGNFLussApGIFGTsFSlLuYsKPlLIGlslILLllLlhKIlSWLss..c+K+p	....MTLQQWLlW+..........KMs-AHsALpNsooLTEEQKpQlIlEIQ...pEEV.l..PT+MDRlKYLsYsCCATuTRVMsWlhLIClLLIIVhVSCFVTVuRIQWN+DIsVhGPVIDWNVT.pp.AsY.QpLpssRloRSLRspHPc.pYlplNMoSIPQGVhYsPHPEPIIlKERVLGlSQVLMINSENIANsANLoQEsKhLLs-MINEELpsLSspMIcFELPLGDPRDQpQYIH+KCYQEFAHCYLVKYKp.P.psW.o-slIsDQCPLPGh.HssshYcYQsIWDYYlphppIRPpsWTocoa..YGs....ARhGSFYlPp.hRpssloHVlFCSDQLYGKWYNlpNslpENEpLL+oKLhN..LTsh..SpLKsRALPppWsspGpucLFRshNsLDlCN+PEAVLLLNoTYaoaSLWEGDCsaTps.Ipph.sEC+p.s+h...chhHPYACRFWR...aKp.spEEVKChssEc.c+CLYYscYsSPEupaDFGFLuYLsAFPu.hCIEspslR-s-YEVYSLYhEChNuAcpaGIDoVLhuLKoFLNaTGsPVNEMssARAFlGLoDPKFPPsYPNlT+E..p+uC..ps.pR++RS...sNlcKL+SM...............................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2595	PF03623	Focal_AT		Focal adhesion targeting region	Bateman A	anon	[1]	Domain	Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin [1]. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not.	21.20	21.20	21.70	21.30	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.62	0.71	-4.69	7	286	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	84	30	140	236	0	126.30	54	14.58	CHANGED	TtsLDRosDhVYpsshslVKuVhpLpstlpphssp-YlshVKsVGlsLRsLlsoVDclhssLPups+pEIEhspKlLsKDhuELIutMRLAQQ.uhToLcp-h++pMLoAAHsLAhDAKNLLDsVDpARl+hphhh..Pt	................TAsLDRosDpVYpsVsslVKAVlphssclp.us..PEp.YVs.hVKpVGLsLRsLluoVD-hlPhL.P....uSo.++E.I...........EMA..p..KLLN.pDLuELIsKM.+LAQ.Q...ash.TSLp.pE....YKKpMLoAAHsLAlDAKNLLDslDQARl+h.h.....t..................	0	58	67	101
+2596	PF02980	FokI_C		Restriction endonuclease FokI, catalytic domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	104.30	103.10	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.71	0.71	-4.53	4	21	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	21	3	3	25	0	139.00	41	24.27	CHANGED	upEc-lLhpAlLuYPPAspILoLLt-t.GpahTKF-LGcpLGFhGEpGFTShPpsIhlcsLAsup.st-K...pKIKosaEGoSDKYARhIusWLcplGLVpptsKpVhh.ThtpRKap..lupsa.ITu.GlpsLpcspGpoRas	....t.p-pclLpcAlLuYPPAsplLsLLsst.upthTKFpLGcpLGFhGEtGFTShsp-lhlpsLspAp.sp-K...pKI+SshEGTSDKYARhIsuWLhplGLVpppsKclsh.shssccap..shs.psYpITs+GlpAL+pspGpS+a.s.......	0	1	1	3
+2597	PF02981	FokI_N		Restriction endonuclease FokI, recognition domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	29.00	27.50	22.90	19.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.70	0.71	-4.58	3	21	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	21	3	3	25	0	143.20	34	25.01	CHANGED	lhloEsS+lR..TFGWVQDPS.DF+sLs+VVuIFDcsSKlHpELtsp+IPsLVcEpclRpELlullNQ+PLplTYK-LVGTuho.RScAcCNuIVQAsl..pGQ.sRsaIsDWuADNFVRWAHALGFL+YtppuDoFsITElGlAhuKutD	..............chR..TFGWlQssS.shppLKKVVslFsssSchappLhcshlt.pllp-tsh+pcLhscLsss..shphoYhcLsGss.......h.......p...........RocuhssuLlQAsl.....puQ..u.....+tahcDWsADuFLRWAVulsFlcaspcsDTFsITchGhphsp................	0	1	1	3
+2598	PF01770	Folate_carrier		Reduced folate carrier	Bashton M, Bateman A	anon	Pfam-B_1123 (release 4.2)	Family	The reduced folate carrier (a transmembrane glycoprotein) transports reduced folate into mammalian cells via the carrier mediated mechanism (as opposed to the receptor mediated mechanism) it also transports cytotoxic folate analogues used in chemotherapy [1], such as methotrexate (MTX). Mammalian cells have an absolute requirement for exogenous folates which are needed for growth, and biosynthesis of macromolecules [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.32	0.70	-5.96	24	433	2012-10-03 03:33:39	2003-04-07 12:59:11	13	6	105	0	249	620	26	306.20	34	82.78	CHANGED	psWhh.ohlLChaGFhpphRPuEPFlssYLhGs.+NlTp-QlssplaPVhTYSYLAhLlsVFLlTDaLRYKPVIlLpuluhlssahlLlaspulhshQhhEhFYGlspAuElAYaoYIYuhVs......ppYQ+lTuYoRuuhLlGhhhuulLuQlLVo....hsthsahpLNhISLushsluLhhuhhLPtsp+SlaFppp..............................ppscspphppsppps......hpt.t..shpt...psl....tthhpchtssYss.pllhWSLWWAhuouGahQllsYlQlLWcpl...sspssplYNGuV-AsuTLLGAlsuhusGal..phpashautLsLulhSslpuGhlhlhshop...sIWlsYsuYllF+uhYhFlITIAshpIAssLsh-paALVFGlNTFlALhLQTlLThlVlD.ppGL..sLslpsQFhV	....................................................................W.h.shhLCh.aGhhtth+P..u.Esalh.aL.h.t....p...NhTtpp..l..p...........plhPhhoYS..als.hL..h...lF..l...hTDhl.RYK........Plllhpu.hu..hlh.h.ahh..Llhs..ps..l...hthQh...............hphha................u..........hh....h.A....s.c.l....A.Y...u.Y.Ia.u....h..V.p........................th..Yp.+.h..s....u.a.s.R.u.s.h....Lhu.hhhuul....lu.Q.lhls.....ht....hs.hh...L..thlo.....l.s.....h....uh..h.h.u.h.h......L............sppo...h......aa...pt................................................................................................h....hh.........h.hhtc..h..ht.s.h.pp....lhhWSlWWsh.s..ssGa..lh.....................YhphLWp.h..........pt..t.haNG.ss-A.h.shh........uu.h..ss.hhsuh..l..php.h.sh.h.u.....h.hlshho....h..h..u.s..lhh.h.t.....st.......sI....ahsYss...al.lat...Y.h...h.l...sl........A......hp...lA...........sLs......-.huLlFGhNTFhAhhlpollThl.Vss.ttuh...sL.l..Qah...............................................................................................................	0	72	94	174
+2599	PF03024	Folate_rec		Folate receptor family	Bateman A	anon	Pfam-B_1966 (release 6.4)	Family	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.	29.50	29.50	30.30	29.50	29.10	28.90	hmmbuild  --amino -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.94	0.71	-12.36	0.71	-4.63	34	433	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	99	11	239	412	3	158.80	26	42.97	CHANGED	hCh...........su+paKshPusEspLt.p..........Cssapcp............................uCCssspopphpps.s.hl.ph.hp+CGp...hospCccahhp.pChYcCSPplu.W.............................p...ppth.slP.LCp-.CcpWacsC+ssh...TCsssW.t...athspst.ppC..tst..Chsappha.ssss-LC...................cplaupuaphustt..................uspClp	...................................................Chstp..pp.stsc..tpLh............Cs.appp.................................uC....Cstspspphttp.t........hh..............h.......up...........hp.stCpcahhphtC.hcCSPphu.h....p.....................tp..pphhhslP.LCp....-hCppaap...sC+ssh.......ps....tssh....................pps...h...p.C........t.....C..h.p.hh.....sssshC........pph.hu.s.hthss.....................sthCh................................................................	0	66	87	135
+2600	PF02152	FolB		Dihydroneopterin aldolase	Bateman A	anon	PSI-BLAST P31055	Domain	This enzyme EC:4.1.2.25 catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate.	24.10	24.10	24.10	24.40	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.15	0.71	-3.91	129	4525	2012-10-01 20:59:24	2003-04-07 12:59:11	13	22	3833	60	1029	2777	2126	111.20	28	72.22	CHANGED	lhlcsLchhuhlGlhstE+thsQphhlDlpl....thchp...tssts.Dclppol....sYsplsctl.tphsp.ppp...apLlEsLAcpluptlhpp...........................as....lpt......lp.lplpKPss..ls.tsss.......lulplpR	................lhlcsLchhshhGlhstEpphtQchllDlpl.........thD...hp.........pAupo...D-.ls.c.s.l........s.Y.upl.scpl.tphlp...s.pp...........hpL..lEplApclAchlhpc................................as.....lpt..........lclclpK.PpA..ls..thcs.VuVplpR.................................................	0	309	627	864
+2601	PF00250	Fork_head	FKH;	Fork head domain	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	21.00	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.24	0.72	-3.94	21	4445	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	545	35	2306	4173	4	92.50	42	20.59	CHANGED	KPP.....................YSYhuLIsMAIpp.uPsKhLTLupIYpaIh-pFPYYRpNppuWQNSIRHNLSLNcCFlKVPR......ps-cPGKGuaWpLcPsutshF.s................Gsah+Rc+R	........................................KPP.......aSYss.LIsh.A...Ipp....o.sp+pLTLs.pIYpa..Ihcp..FP..Y..a.....R..........p......s.....p......t.....u......W............p..............NS.IRHNL..SLN.c.C.FlK..Vs..+................t.....s....p.....s...G..........K................G..s..a.Wsl..c...Pss.t....p.h...h.t.......t...............................................................	1	603	883	1588
+2602	PF01226	Form_Nir_trans		Formate/nitrite transporter	Finn RD, Bateman A	anon	Prosite	Family	\N	28.20	28.20	28.60	28.50	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.70	0.70	-5.48	190	4680	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	2481	80	683	2429	127	247.40	28	87.19	CHANGED	stphhpthhps.uhpK...hptshhphhltuhhAGhhIuhushhthhlsssh.................s...........uhspllsuhs.FslGLlllllsGu-LFTuNshhhshuhhpc+..loh.tpll+sWsllalGNhlGulhhuhlhshs...shht...........ts........thstthhplAp......tK..h......sh.s.............hhpsFh+GIhCNaLVsLuVWhsh.uu+sh..huKlhslhhslhsFlssGFEHsVANMhhlshu.......lhh.us..........................s.hhshhhpNllPVslGNllGGslhluhhhahha	..............................hthh.pt.u.tc...hp...ps.h.ph..hlhuhhAGhalul..uhlhhhshssth.................ss................uhsp.Lls.uhs.FslGLllllls.Gu-LFTusshhh....sluhhp..pp.......loh..sp..hh.......p.ahh.........shlGNllGulhhuhlhths..shht...............s.......................................thspt.hh.pl.up.tK.h................pp..s.....................................h.hphhhpGIhsNhhVslAlWhsh..t..s.c.ss..hsKhhshhhslhhFlhsGaEHs........lANhhhhshu...lhh..sp.................................s.hhsh..lhpNllsshlGNllGGulhhGLsYahh................................	0	205	396	569
+2603	PF02971	FTCD	formiminotr; 	Formiminotransferase domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	24.00	24.00	25.40	26.60	22.80	23.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.74	0.71	-4.56	4	394	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	349	6	124	337	180	124.30	43	33.96	CHANGED	FLIAFNINLLuT+..E.AHRIALslREQGRGtDQPGpLKKVQuIGWYL-E+NlAQVSTNLLDFEsTsLHsVaEEsChEApcLuLPVVGSQLVGLVPLKALLDAAuFYhcKEpLFlLp-E++I+LVVsRLGLDSLsPFpP+ERIIEYL	...............LlAaNlNL...s.T.s..l-IAccIA.KtlRtpu.......................................................................GGh+alKAlGl.Lc.......-+.....slsQVShNlsDap+TslaRsFEpl+hEAc.RaGVsVlGSE....llGLlPhcALlDsAcYYL.p....h.E.s.h..........................................................................	0	62	84	104
+2604	PF02911	Formyl_trans_C	formyl_trans_C; 	Formyl transferase, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-3.92	130	5755	2009-01-15 18:05:59	2003-04-07 12:59:11	13	28	4563	24	1384	4263	2359	99.70	28	26.51	CHANGED	+lspp-stI-W.spsAppltphlRuh...s.PaP.uAas...hh....ss.......p....pl..........+lhcs.......phh.....spttttt.......................PG...p.....llphspp.slh.lssu.sus......ltl.ppl..Qhtuc+hhsspshhp....Ghp	....................pls+--ucI.D.W...spsApplppplRuh........s..PaP..sAas....hh..............ss..........p...........pl...................................Klapu.....................phh...........ssss.stt.....................................................PG....p.......llp....s...s....cp....slh..lAsu..sGs...............Lpl..tpl..Q...sGK+.t.h.sstsahpGh.t.........................................	0	435	862	1141
+2605	PF00551	Formyl_trans_N	formyl_transf; 	Formyl transferase	Bateman A	anon	SCOP	Domain	This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces formate from formyl- tetrahydrofolate. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. Inclusion of the following members is supported by PSI-blast. HOXX_BRAJA (P31907) contains a related domain of unknown function. PRTH_PORGI (P46071) contains a related domain of unknown function. Y09P_MYCTU (Q50721) contains a related domain of unknown function.	20.80	20.80	20.90	20.80	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.94	0.71	-4.74	15	13471	2009-01-15 18:05:59	2003-04-07 12:59:11	14	85	4844	104	3486	9789	6453	174.10	26	55.92	CHANGED	h+lsllhSGsu.oshpsl.lsth+psstp...spllhVlos+spstGhp+utpsslsptlhpcps...................apsc.tthcpcltctlcthpsDllllAuah+lLssshl.pthss+lLNlHPSLLPpa.....cG.ssslppAlhsGscc.....sGsTlaals.-plDsGsIlhQpps.lhs.s-ossslppRlp-tEt.pshscsl	.........................................................................................................+lhhh...Gp...s....p.....h..t..sl....l.p...t.hh.ts.th.............ls..s..Vh..o..p....s.c...s...h..s....h...t.t......s..h.p.....h..s......s..t.h.h....h.....t.ps..............................................h.psp...t..h.c.p...p....h...h....p...t...l...........p.....p...........h.......p...s.....D.....l.l.VlA.u.Y.h.p..l..Ls.sp.ll....p.........t..h..............t.....t.............t......h..l.NlHs...S..LLP........pa...................+.G...usP.h......pp...A...l........s....G.s.c.............................sGsTlH.....h.l...........s...p...........t..lDsG.s.Ilt.Q.t........t....l....s...l........pt...sDost...s.Lh.p.+l.t.p.h.tt.pl.lsps..............................................................	0	1084	2180	2908
+2607	PF01491	Frataxin_Cyay		Frataxin-like domain	Gibson Tj, Bateman A	anon	Gibson TJ	Domain	This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia.  This domain is found in a family of bacterial proteins.\	  The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.	21.30	21.30	21.80	21.80	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.65	0.72	-4.26	96	1466	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1409	24	414	878	102	106.10	41	86.45	CHANGED	hs-scapplu-phlpplE-tl-th..-ss.....................hDlDs-hs.uGVLTlpF.s.stuphlIN+QsPh+QlWLAo..SGGaHFcap................s.sp..W.lss+.sGp.phhshLscthsppsups.lpas	...................................Ms-oEFHcLADphh.sIE-plDph..-.uc.....................sD.l.DsEh.s....GG.VLTlsF.....-suS......pIlIN+QpPh+.QlWLA.o+.pGG...aHFchp.....................s..sc..Wl..........ssR...sGp.shaclLpptsoppuGcslph.p..........	0	105	209	318
+2608	PF03197	FRD2		Bacteriophage FRD2 protein	Mifsud W	anon	Pfam-B_2816 (release 6.5)	Family	\N	21.60	21.60	21.80	50.80	20.90	18.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.32	0.72	-3.47	6	36	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	32	0	0	28	0	99.60	58	79.79	CHANGED	sMVclIc-NGGWFEVK-hpss.DGh.csVs+IpCANGcha.ssG.h-pYFEIpEDEF+CFREY...TsEcDElcccV..oGVTKIHCIVDENNVDEIIELLRKTFKK	.sMVclIpENGGWFEVK-htsh.DGa.chVp+IpCANGcha.s..G.h-cYFElsE-EFaCFREYKE.TSEcD-lcDcV..SGVTKIHCIVDENNVDEIIELLRKTFKt..	0	0	0	0
+2609	PF04422	FrhB_FdhB_N		Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	Kerrison ND	anon	DOMO:DM04087;	Family	Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420.  This family contains the N termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2].  The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.47	0.72	-4.12	116	542	2009-01-15 18:05:59	2003-04-07 12:59:11	8	32	327	0	298	541	181	79.70	26	20.16	CHANGED	tchhtApusst..hppuQsGGhVTulhthhL-pGhlDuVlsst....psp...................c.acshPhlssss--lhpsu..Go+as.hsshhphlcc	...........t.thhhApsp.p...hp.tupsGGlVTslhthhL-p.G.hlDuVlssp....psp................................c.a.pshshlspss--llp........ss..Go+as.hsshhphlt................................................	1	80	189	254
+2610	PF03881	Fructosamin_kin		Fructosamine kinase	Bateman A	anon	COG3001	Family	This family includes eukaryotic fructosamine-3-kinase enzymes [1]. The family also includes bacterial members that have not been characterised but probably have a similar or identical function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.81	0.70	-5.43	35	2015	2012-10-02 22:05:25	2003-04-07 12:59:11	9	10	1716	3	561	1603	432	272.80	31	95.06	CHANGED	MWpuIup.lo-phGpsapIpc+pplsGG-Ispsahls........cuppcaFVKlNp..cshLshFcuEA-uLphLscopolpVPcslshGss.cspu............aLlLEaLshp.hsstcsthphGppLApLHp.......hssptpFGa-hDNhlGsTsQPNsWpccWusFFu-QRIGaQLpLsc-+Gh.p...husl-pllcpltphL................ssHpPpPSLLHGDLWsGNsuhsss.G..........PllaDPAsYaGDREsDLAMoELFGGFPssFYcGYpslaPLs...sGYpcRKslYpLYHlLNHhNLF...GGpYlspApphlcpl.Lpp	......................................................................................................................................................................................................h..ht.ls..G.Gp..lp.t.s...a.t.....lp...............h.stp....p.hFl..K..spp...............tph.....h.s.....h..F.p....u..Es..s.tL....p......h......l....t.....c......s........t.......s.........l..p..........l.Pcl..h......s..s....G.ts...p...s...t.u.....................................a...Ll.h...-........a.....L.........s.......................t.....................s...........s.........ps.........s..........hpL........G.pp.........lA.c...LHp.................................hps.pspF.....G..........a.....c.....hs.....s.....t.....h.G.s.........h.....s........Q....s.....N......s........W........p.....c......c.....W...s................s...FF....u...c...p.R.....l....s.h.........lc..h..s.t...c..+...Gh.h..............hsp.h.c...p....l..h....c....p...l..t.p..t..L...............................t..s...+..p.s.....p...P.SL...L.......HGDLWuGNshhsss..G...............................................Ph...laD....P.A.....s.a..a.GcR............EhD..L.....A......h....h..t..l.....F...........s...s....h.....s...s..p........h...a.c.uY...pp....h.....h.....P....Ls.....ts.a...pc.Rhsl.YpL.Yh...LL.s.+.ht.hF...G..u.t..ahs.tstp.hcplh..t..........................................................................................................................	1	143	323	454
+2611	PF04961	FTCD_C		Formiminotransferase-cyclodeaminase	Bateman A	anon	COG3404	Family	Members of this family are thought to be Formiminotransferase- cyclodeaminase enzymes EC:4.3.1.4. This domain is found in  the C-terminus of the bifunctional animal members of the family.	21.80	21.80	23.30	23.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.73	0.71	-4.87	75	717	2009-09-11 00:17:51	2003-04-07 12:59:11	7	8	621	6	232	659	206	179.80	33	69.85	CHANGED	holp-FlctlAScsPsPGGGSsuAlsuAlGuALssMVupLTl.GKKpYtph-s....phpplhppscphppcLhshlDcDscAFsplhsAa+LPKpTcEE+ttRptslQcAl+pAspVPlplAcpshchlplhptluphGNtsslSDssVushhscAAlpuAhlNVpINLs....sl...cDppahpchppchpplh	.............olpcFlctluScsPsPGG...GosuAlsuAlGsALssMVupLTl...GK..+p.Ytp.hcp...................phpplhpp.s....p.plpp....cL....lphlDcDscAFstlhsAaclPK...pT-....EEK.stRppslQ....p.uhcp.AspVPhplsctshcshpl.hpphsppGNpsulSDsuVushhhcuulpuAhlNVhINLs....ul...+D.cpaspphppchpplh......................	0	116	171	202
+2612	PF01268	FTHFS		Formate--tetrahydrofolate ligase	Finn RD, Bateman A	anon	Prosite	Family	\N	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.70	0.70	-6.53	141	4825	2012-10-05 12:31:08	2003-04-07 12:59:11	14	10	2767	19	740	4276	2739	447.70	51	94.46	CHANGED	hhSDIEIAppsp..hcPIpclAp.cl.Gltp--..l-.YG+aKAKlshs.hlc..pl...ps+..............sGKLlLVTAIoPTPuGEGKTTTTlGLupAL.s+l......GKcshlsLREPSLGPsFGlKGGAAGGGYuQVlPME-lNLHFTGDhHAITuApNLLAAhIDN+lapsN.p......................................................LsIDscpIsW+RVlDhNDRuLRpIslGL...Gupt..sGhsREsGFDITVASElMAILCLusD......LpDL+cRlG+IlVuas....hcspPVTAcDLtssGAhssLLKDAI+PNLVQTLEsTPAhlHGGPFANIAHGsNSllAT+hALKLuD...............YVVTEAGFGADLGuEKFhsIKCRhuG.LpPcAlVlVATlRALKhHG....Gl.shss...............LspENl-ALccGh.sNLp+HIcNlpp.aGlPVVVAIN+FsoDT-uElphlcchs..p.ph.Gsp.sslspsWuc..GGcGuh-LActVlcs......pppsu.p.........FchLYssch.slc-KIpsIApclYGAssVphospAccplpphcchG.ascLPlChAKTQYSlScDPslhGsPpGFslslR-l+lusGAGFlVslsGclMTMPGLP+pPAA.sIDls.-sGpIsGLF	...............................................................................................................................................................................................................................................................................thoGDhH...AIsuANNLLAAh.lDNHIaQGN..p.......................................................LsIDs+c...IhW+R............s.lDhNDRtLRplssGL......Guph..............sG..h.sRE................DGFDITVASElMAILCLuss......lpDLKcRLu+IlluYs......h......c.s......p....PVT..spDLpspGAhssLLKDAlKPNLVQTLE..sTPAhlHGGPFANIAHGCNSllAT+hAL+.Lu.D...............YsVTEAG.F.GADLGAEK.FhDI.KCRhuG.lp.PsAVV.......lVATlRAL...KhpG....Gl....s+sp.....................L.sp.ENl-Al.cpGh.sNLt+HlcNl.pp.aGlPsVVAIN.pFs.o....DT-AEl..phlc......chspph....G....sp....sslspsWucG..GcGuhcLAc.pVlchh..........p.p....s....s...................FphlY...c.....c..h....slc-KIctIspc.lYG..A..ssVphss...p......A.p.cpltp....hp....p........G..asphPlshuKT.h..................................................................................................................................	0	264	454	610
+2613	PF03239	FTR1		Iron permease FTR1 family	Bateman A	anon	Pfam-B_3227 (release 6.5)	Family	\N	22.50	22.50	22.70	22.50	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.92	0.70	-5.47	13	2689	2012-10-03 03:33:39	2003-04-07 12:59:11	9	11	1826	0	661	2163	330	227.80	21	69.51	CHANGED	hhuhhllshREuLEAulllollluhlKp........................................................................stccppt.................t.lahGhhhulhhululGsuhhthhtultt.......hpc-lhEuhhShlAslllohMhhaMt+...up+l+sclctplspslt..................t.paulhlhsF......lsVlREGlEsVLFluuhsttss........ssshlusssGhhsuslluhhlapsuh+lsLptFhhhsoslLhhluAGLhuhu....hhthhchspt.pGhchhthspussshshsh.ushthshhssthsu.....llhslhGahsp..........hhhlhlllhluhhhht..hshthh	............................................................................................................................................................................................................................................................................................................................................................................................................t..h...h....ht..hh..h...h.t......................ht...t..hpt.........th....h..................................................................................................................................................t....t..h......hu....l..h...h...h...s.F.........................lsl...hREGlEs.llF.lhulhttts.............thhhh.hGs.hh.G...lh...s...u....h....l....l...u...h.l..l.h....h....s....s.....h..c....l....s....h.t....t.....h....h..h.hsuh..hl....hhlussLhutu..........hhthhp.t..s....h.......h.....p..h.............t.s........h..h.....p..t..s.h......hh.......................................................................................hh........................................................................	1	181	389	559
+2614	PF02491	SHS2_FTSA	FtsA;	SHS2 domain inserted in FTSA	Anantharaman V	anon	Manual	Domain	FtsA is essential for bacterial cell division, and co-localises to  the septal ring with FtsZ. The SHS2 domain is inserted in to the RNAseH fold of FtsA [2], and is involved in protein-protein  interaction [1].	25.40	25.40	25.60	25.60	24.90	25.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.50	0.72	-4.09	50	3487	2012-10-02 11:08:51	2003-04-07 12:59:11	15	8	3448	5	697	1941	882	80.40	34	18.91	CHANGED	uGsplpshsspGhls..hpscEVsppDlcRVlcsApshshss...-pcILHslPpcasl.DspcGI.+-PlGMsGsRLcscsHllTs	........................Gtplps.sspGhls........hpscElo.ppDlcpV.lcs.A.p.s.h.s.lss.......-ccll+.llPp-ahl.Ds.p..c.G.I..+-P..lGM.G.l.RLcscsallTs............	0	222	434	570
+2615	PF01580	FtsK_SpoIIIE		FtsK/SpoIIIE family	Bashton M, Bateman A	anon	Pfam-B_458 (release 4.1)	Family	FtsK has extensive sequence similarity to wide variety of proteins from prokaryotes and plasmids [1], termed the FtsK/SpoIIIE family.  This domain contains a putative ATP binding P-loop motif. It is found in the FtsK cell division protein from E. coli Swiss:P46889 and the stage III sporulation protein E SpoIIIE Swiss:P21458 which has roles in regulation of prespore specific gene expression in B. subtilis. A mutation in FtsK causes a temperature sensitive block in cell division and it is involved in peptidoglycan synthesis or modification [1]. The SpoIIIE protein is implicated in intercellular chromosomal DNA transfer [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.18	0.71	-4.85	23	9858	2012-10-05 12:31:08	2003-04-07 12:59:11	13	40	4316	14	1937	10212	3173	196.90	29	27.52	CHANGED	pltphhsspthctstsphslshGtph.tspslhh-lschP........HhLlsGuoGSGKSsslpsllhSlhhptpPpcVclhhlDsKhs.cLsshpslsHlhs....slsscsccshpsLctllsEMccRh..plhpphslcslst.....hppphsp..ht...................................................hs.lllllDEhs-Lhhssspc........lpshlsRluph......uR.....usGlHLllAs....................QRsus	.............................................................................h...............t...t.....l....lsl..Gpsh...t....spslhh.D..L.s..c.hP............................HlLl..AGs.T....G.SGKSs.h..l.p.s.llhS..l..l..h..p...t...p...P..........c...c.........l....+...h..h.h.....l.D......P..K............h........s....-........L.......s..s.......a.....p........s.......l........P.Hl...hs...................sl.s...s..-...s...c..c....u....s....p..s.Lp...h...h....s...s.E.M...c...c...Rh........clh....s.p..h......s..s.+.s.lst.............asp..t...h..t..p.............................................................................................................................................................................................................................hPhlllllD.E...h.u-.L...h........h...s...s...s...pc.........................lpp...h...l..t+....l.uph...........uR.......us...GlHl.llAT......QRPs...........................................................................................................................................................................................................................................................................................	0	624	1301	1668
+2616	PF04999	FtsL		Cell division protein FtsL	Bateman A	anon	COG3116	Family	In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein Pfam:PF04977 [3], however this interaction may be indirect [4].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.04	0.72	-4.27	66	1462	2012-10-02 13:28:50	2003-04-07 12:59:11	8	3	1456	0	307	877	315	93.00	37	83.99	CHANGED	Ls...thlhtsl.th.plhll....LhlhllhoAluVlassHpsRphhsp....hpphhpc+-pL-hEWtpLlLEpsshup+uRlEplApccLsM...phPssscplllp.	.......................................h.........h...s+lslh....Lhlsll..lo..A.ls..VV..h...s..s..H....p..oR..hLh..s.p.......h-ph....h.hE+....-tL....-h.E.WcpL..lLEcsuLu.c..HS.R.VEplApcc.LpM...ppscsuppsllh.t.....................	0	85	172	247
+2617	PF03799	FtsQ		Cell division protein FtsQ	Finn RD	anon	Pfam-B_1605 (release 7.0)	Family	FtsQ is one of several cell division proteins.  FtsQ interacts with other Fts proteins, reviewed in [1].  The precise function of FtsQ is unknown.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.26	0.71	-10.49	0.71	-3.91	180	3219	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	3193	6	616	2021	863	117.40	20	39.22	CHANGED	lAhWpp..s.t..tllsppGplhts..................phs..t.s.sLPhlhG........ssspp.h.......hphhpph.th.ss.lthplsslphsspps....WplhL...s.....s.Ghp.lhLsps.......s..htp...............+lpphsplhtph............t.......pp.........lth..lDlR	.........................................................lAhhps..p....thl.spsGpshss...................shs...phs..shP..h..l..h.G....................................pss.p.p.l...............hphh.pp..h.s....ph..sp....l....p.....hp..lpplshsspcs.............hpLhh.........s.............s...Gh...p..lhlsps................s....htc.................+.lthas.pl..h.pl..............t...tp.........lth.lDh....................................	1	173	372	497
+2618	PF01098	FTSW_RODA_SPOVE		Cell cycle protein	Finn RD, Bateman A	anon	Prosite	Family	This entry includes the following members;    FtsW, RodA, SpoVE	20.10	20.10	20.40	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.25	0.70	-5.67	15	10114	2012-10-02 17:14:55	2003-04-07 12:59:11	14	11	4374	0	2079	6986	6687	345.20	28	90.11	CHANGED	hpLlhhlhhLhs.hGllhlaSASshpuhshhsss.hhhhh+QllahllGhllhhlhhplshp..hhp+hthhhallsllLLhllhl....lGssssGA+RWlslG..slslQPSEhsKlulhlalAphlupt............t..hpsphcshhhsll.hhhlhsslllhQPDLGTulllshhhhsllahuGhsh.phhlsllh......lulsshlhh....lhhcsY....phpRltuaLsPapDPh.....GsGYQlhQSlhAluoGGlhGpGlGpupQ.KhtYLPEupTDFIFAlluEEhGhlGsllllhLahllhh+uhpIAh+...spcpFtpllAsGlslhlhlQshlNIGhssGllPlTGlsLPalSYGGSSllshhsshGlLhsluppppt	............................................................................................................h...hhhhhllh..lG.llh..l...h..S..u...o.....h................s..............t..........h....h.........t..........t................h......h......h...h....+...Q.hha.h...h....l..u..h.l...h.....h...h..l...h...h...h.l....s..hc................hh..p..p..h......s..h....h..h...h...h...........h.....s...l...l..l...L...l........h.......l...h.h..................hG...t.t.....s..p.....G.........A......p.......p............Wls..l.G......sh..s..h.QPSE.h.hKl.sll.l.h....l..A....t.h...lsc.....................................p......h..h..s....p....h.......p....s......h......h....h....h.....hh.........l........h.h....l....s..h.h..L..l.....h..h..Q...P.....D.....L..G..o...s..l.l....l....h...s...h.....hh........s....h....l......a.........l.....u.........G....h.....s.......h.....p........h....h..h.....s.....hhs..................hh.s..h.s..s..h..lhh..................................................hhhp...sY.......................p..hpRlh..s..a......l...s.....P....h....p...c..s............................usG.Y....Q.l.hp.S..hhA..lG.s....G.G..lhG..p...G....h.....s.....p.......ut..........p.....p.....h.....t...a....L..P...E........s..cTDFIFulluEEhG.h.l.Gshhll.hLahhllhR.s.h...h...l...uhc............sps.......F..sp..h.lusGl.......shhh...hhpshlNlGhs..hGl..l.P.l.sGls.LPhlSYGGSSllshhhulGlllslstpt..t............................................................................	1	736	1429	1800
+2619	PF03867	FTZ		Fushi tarazu (FTZ), N-terminal region	Finn RD	anon	DOMO:DM07486;	Family	This region contains the important motif (LXXLL) necessary for the interaction of FTZ with the nuclear receptor FTZ-F1. FTZ is thought to represents a category of LXXLL motif-dependent co-activators for nuclear receptors.	25.00	25.00	28.60	27.10	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.01	0.70	-5.15	3	27	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	17	1	8	31	0	259.90	70	61.39	CHANGED	MATTNSQSHY.YAD..NMYNMYH...sHSLPPTYYDNSuSsSuYQsTuptWQ..PASYQSNYtAaYu.QESYSESCYYANspaQ.............PTssTVPQ.PsVPThPEPlltsS...PVKupKRKAEDsAAuIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTlEpVKKuP...PupoKuouSPAPSYEQEYVAVPTP...........SASEDVDYLDVYSPQSQsp+.KNGDFl..TPPPhATTPsossuI.EGISTPPQSPGEKSuoA..VSpEINHRIVTAANS..AuDFNWSHIEETLA	....................................................MAsTNSpSH.Y.Y..AD..NMYNMYH.....sHSL.PP....T..YYDNSuS..suhYQs....S.........uoYQ.SYtu.hYs.QESYSESCYYhNsQcQ............................p.stT.VP..Ps.Pss.......P.P...............KupKRKAE.....EsAAuIIAAVEERPSTLRALLTNPVKKLKYTPDYFYTTlEpVKKuP...sspoKsAuSPAPSYEQ...EYVsVPTP...........SASEDVDYLDVYSPQSQ......sp+....KNGDFs..TPPP..TTPs........ohssl...EGISTPPQSPGEKSuoA...VSpEINHRIVTAsNu...AuDFNWSHIEETLA........	0	2	2	5
+2620	PF02952	Fucose_iso_C	fucose_iso_C; 	L-fucose isomerase, C-terminal domain	Griffiths-Jones SR	anon	Pfam-B_9303 (Release 8.0)	Domain	\N	28.90	28.90	28.90	29.00	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.78	0.71	-4.68	45	1454	2012-10-02 11:40:13	2003-04-07 12:59:11	12	4	1208	15	185	864	123	155.10	38	29.63	CHANGED	ppshlhLhpsGsss......t.................pphptshptsphhstsppahpGu....shuophtphsssslThhRLs..cs.G.l.hhlucGpsl-hspc..spsplshpss.phspsaht..hs.p.........plhsshhuNHsuhsaGchupsLhphs.phLtIshs.h+	.............................................t.pGhlcLhNSGussLsh......tttpttt.t........hW-lppp-spusLtsTc.assA.h+..cY.F.RGG...........GaS.o.pF..hT.pu...ssPhThsRlNhl+GlG...PV.LQIAEGho.l-..LPc.c..sact..L.s.p.R..Ts.s.sW.P..oTaFs.s.R.lsucssF..psVYsVMsNWGANHuslshGHlGADllTLA.uMLRIPVs.MH..................	0	82	141	159
+2622	PF02300	Fumarate_red_C		Fumarate reductase subunit C	Mian N, Bateman A	anon	Pfam-B_11568 (release 5.2)	Domain	Fumarate reductase is a membrane-bound flavoenzyme consisting of  four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hydrophobic subunit C.	22.50	22.50	22.70	22.60	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.80	0.71	-4.27	23	798	2012-10-03 07:11:12	2003-04-07 12:59:11	12	2	794	18	71	276	17	127.10	62	97.67	CHANGED	soKRKsYVRpMpssWWpKhsFY+hYMlREuTulsslWFslVLlaGlhuLsp....GssuassFlsFLQNPlVllLNlIuLhusLhHshTaFphsPKsh.sIhlKsc+lsspsIlpuLWAlTslVSllsLslshl	................hoKRKPYVRsMTuTWWKK.LPFYRFYMLREGTAVPAVWFSI.LIaGLFALKs...........GP...E...u...WtGFV.sFLQNPVlVIlNLITLAAALLHTKTWFELAPKAA.N.I.I.VKsEK...MGPEPIIKu.LWAVTsVsTlV.ILaVAL.h......................	0	8	27	50
+2623	PF02313	Fumarate_red_D		Fumarate reductase subunit D	Mian N, Bateman A	anon	Pfam-B_12414 (release 5.2)	Domain	Fumarate reductase is a membrane-bound flavoenzyme consisting of  four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 13kD hydrophobic subunit D.	25.00	25.00	28.90	28.90	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.46	0.71	-4.21	21	816	2012-10-03 07:11:12	2003-04-07 12:59:11	12	3	799	18	72	251	10	113.80	66	96.91	CHANGED	hspsPKRSsEPlaWuLFGAGGMlsAhlsPVlILllGlLlPLGlls.tshsacplhuFApoalG+lhlLlllhLPhWpuhHRlHHGh.HDLKlHh.ssuphla.YGhAslholls..hhhVhs	.....I.NsNPKRSDEPVFWGLFGAGGMWuAI...IA....PVhlLLV...GILLPLGL.h.P.uDAL.SYERVLAFAQSFIGR...lFLhLMIVLPLWCGLHRhHHAM.HD.LKIHV.P.A.GKWVF.YGLAAILTVVTlIGll.T.................	0	8	28	51
+2624	PF03630	Fumble		Fumble 	Finn RD	anon	Pfam-B_3299 (release 7.0)	Family	Fumble is required for cell division in Drosophila.  Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with  high similarity to the pantothenate kinases of A. nidulans and mouse[1]. A role of fumble in membrane synthesis has been proposed[1].	21.20	21.20	21.20	21.60	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.90	0.70	-5.59	11	1080	2012-10-02 23:34:14	2003-04-07 12:59:11	9	12	701	15	460	840	178	273.20	33	69.95	CHANGED	s+lulDIGGoLsKLVYassps.sspp.pp..t.h.p...............................tGRLpFlpFpTpcIsphlpah+p.............pshsp.phslpATGGGAaKFt-hh+cplsl..plp+.DEh-sLlpGlsFllp...sl.pEsFsap.sp-sE..h.....phs.tsshYPYLLVNIGSGVSIltVpGpspacRVuGoSLGGGTFhGLssLLTsspoF-EhL-hAp+GDsoslDhLVtDIYGsc..Yp+hGLsusslASSFG+sh.....pcsKp....................ppaspEDlu+SLLhsIoNNIGQIAhhpAhppslcRlaFsGsFlRspshoM+TLoYAlcFWSpGphpAhFL+HEGYhGAlGAFLpht	.........................................................................................................................................................................................................................................................................................................ts.p..hp..Fhp.....o.p......ph.p.p.....hl.phhpp..............................................................hlphTGGsA...hh.h.....tp....................h...s..h......th.h.sEh-.shh..................pGl.hl.p................E..............................................................................................p..hps.....hh.salllNlG.oG..........sS..llhl..p..u..p..s..p...h...cRVuGo..ulGGGThhGLspL........L..o.t.h.p.....s.a--hlp...hA.p........cG......DpsplDhh..VtD.IYuss................c....s..Lsu.shsA..S..sFG+sh..............pp..t...p.t.......................................................................thoppDlstullhhl................s..psIuplAh.hhAtpp......pl.ccllahG...shh+sp....h.hhchl..s...sahsh...............tthpshFlc..ctua.GAlGAhh...t............................................................................................	0	148	239	359
+2625	PF04930	FUN14		FUN14 family	Wood V, Bateman A	anon	Pfam-B_8237 (release 7.5)	Family	This family of short proteins are found in eukaryotes and some archaea.  Although the function of these proteins is not known they may contain transmembrane helices.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.22	0.72	-3.72	34	431	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	305	0	272	412	7	95.60	28	60.52	CHANGED	QlulGulsGassGashpKluKlshhslGssllhLphhpppGhIplsWpplpptlppstppst...................shhpphhshl..ts........................shsuuFsuGh.hlGht	........QlshGulsGhssGahhpKluKlsAhslGsuhllL.QhhsppGal....plsWp+.lpc.p.h.p.p..s..pppht...........................................................h.phhp..ph.hphlt.tsh..........................hsuuFhuGhhlGh.............................................	0	82	127	205
+2626	PF01475	FUR		Ferric uptake regulator family	Bateman A	anon	Prodom_2003 (release 99.1)	Family	This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes.  This family is also known as the FUR family.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.39	0.71	-4.18	24	9302	2012-10-04 14:01:12	2003-04-07 12:59:11	14	10	4091	22	2167	5940	4980	119.00	26	80.09	CHANGED	csGlKlT.pRhpILpllppscp...HhoAE-lYctlh..ccsspluLuTVYRsLphhcctGllpchphs.sucshaElsp...tcHHcHllChcCGclhEFpsspIEphppclsccpGa+lhsHplplY	.......................................t.tGl+h.T.pRhtl.L.c.l.l.hpp....pp.......H..hoA--laptlp...........p..p.........t...s..p..l...u....l....u............TVYRsLphh.t-tG.l.l.c.c...l..p..........hs.....s.......u.......p......s...h..a....-..........h....sp...............tc.p.......H......p.......H...........l.....l......Cpp....C.G......cl..h...-....h....p....s......s............l.....p....p.....h.t......p...p....l...t...t....p...h...uaplppppl.h...........................................................	0	737	1498	1892
+2627	PF00757	Furin-like		Furin-like cysteine rich region	Bateman A	anon	Bork P	Domain	\N	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.75	0.71	-12.75	0.71	-4.55	40	888	2012-10-02 14:20:19	2003-04-07 12:59:11	15	44	120	49	334	892	2	154.30	37	12.91	CHANGED	scpCs.........ssp.sp.......t.s..CWuss........cCQ..................plCsppCst..tCp.....ssscCCH.ppClGGC......ouPp.sosChAC+capp....sGpClspCPs................upYpF.GtpCV..cpCs............................ps.hlh.....csupClhpCPsuhpcst......ssstpCp.Cs.Gh.CPKlCp	...................................t.s...........t..t.Cp.ss...........tts..CWups........pCQ.........................tphCsp.pCst...pChh..............pss-C..CH.ppC.s.G.GC......oGPp...ss-C.l.AC+pF.c.......sG..sCh.....pp....CPs................u.+.Y..p....a...GspCV.....c.pCP...........................................pp..hlh.......csuuC...lpp.CPsshhcs...........sssttCp.sCs..G...C..P.KsC..............................	0	65	91	210
+2629	PF04632	FUSC		Fusaric acid resistance protein family	Mifsud W, Bateman A	anon	Pfam-B_5345 (release 7.5)	Family	This family includes a conserved region found in two proteins associated with fusaric acid resistance, Swiss:P24128 from Burkholderia cepacia[1] and Swiss:Q48403 from Klebsiella oxytoca. These proteins are likely to be membrane transporter proteins.	30.90	30.90	30.90	30.90	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	650	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.29	0.70	-12.94	0.70	-6.09	92	3210	2012-10-02 19:04:43	2003-04-07 12:59:11	7	8	1176	0	491	3624	82	530.20	21	92.95	CHANGED	phhaulKshhAuhLALalAhtlsLspPhWAhhTValV.upPhs........GhshuKuhaRllGTllGsssulsllshhsppPhLhhhulAlWlulCshhus.h......Rs..cuYuFhLAGYTssllulsuls..sP...ps.....lFshAlsRspEIslGIlCuslVusllh.P...ppsstsltsplpphhtshtphs..sssLssptssst.....................tttplhuclssl-shtstssa-ssphptpsttlptLpschhsll...............shhpultphhptlp...stsss..........ltsh..lpplss.............................ttt.tttht..............................tLhtpl.tshpstht............shtthhhtphhphLtphhpshpshpslppshtt............................................................tpsht..hsh+pDhhhAhhsulRssluhhhsuhhWlsouWsuGusslhhsulssslhustssPs...hshphhhGshhusshuhlhhahllPplss.FshLslsL.usshhhsuhhhspPphus.huhuhslhhshhlu.psshs..hshssahNsulAhllGhhhuslshtll.hPsssphttcRLhpshhpcls.phsptphst...tpt.......tatuphhD+ltpLhsth......ttstspcphhp.slssLclGpsllpLRcthtp..........hssshpts.lcphLpsls.......t..tst.ttt.tsssthhptlppshtthssptsttt...............................tphhssLhtlptsLhs.spsh	..............................................................................................................hhauh+hslAhhL.u....l....h..lu..h......h......h....p........l.....s......p..s......t........Wuhho.s...h..l...V..h.t..P..ts.....................Gslh..+uhhRlh..GTllGsh.s...u..l...l....l.....h...h...h......h.....h........p.....p....P....h........l............h.....l.l...h.h..u.h..h........h....u.h..C..s..a.l..u.t.....................pt....t.u......Ys..h...h.L..A....Gh.T.h.h...l.ls.hs.hhs...pP.....pt.................h.h..p..h.A.l..h.Rss-l..llGllsuhhhshl.h....P...........pps...t....pt...h...p....p...p...L....p.s...h...l.s....p...hh....p....hh.....p.hhpststpt.............................tthttl..htp....h....h...s...h..p.t....h.......t.s....s............h...-...s..........t....p.....h......p.......p...t.......s..........t.......t....l.......p......s......l......p...p....l...ph.h....................................ohh.s...p.h...h..h......p..h.........p....t.th.......................lpph..lppltp................................................stth.ht.p.ht............................................................................pl..hp.l.t..ttttt........................................hp...h..hh..t..p..h..h....hh.h...hh...tph.t.t..p.h....................................................................................................h...hs.thp....h..h.h...hh+shhshhhhhhh..hs.tW..s..h.shhhh.hslss....ths.s.sh....h..hhhshhh.h...huhlhhhhlhs.hpt.h........h.hh.l.s..h.h.h.h...hh.h..t.......p..s...hh.h.t.....hl..hh.h.....s.........hp.h...t..hhs.ps....hu.llGhhhuhhh.hhhl...hs......s.tht...hhtthhtth.....t.h.ph...................t.p.....th.sh.h.........h..h...........................t...h...................t..t....h.h.t...............................ht..h....hhtth............................................................................................................h........................................................................................................................................................................	0	86	207	348
+2630	PF00523	Fusion_gly	fusion_gly; 	Fusion glycoprotein F0	Finn RD	anon	Pfam-B_102 (release 1.0)	Family	\N	20.80	20.80	20.80	22.30	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	490	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.33	0.70	-6.43	12	7380	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	164	82	0	4285	0	200.40	38	89.01	CHANGED	IshstLpplGllssps+phtlhoshpopalVlcLhPsls.......spssCspsplspYpphLscLLpPlt-sLst.pp..ts.......sspRp+RFhGsllGthA...LGVAT..AAQITAulALscAppsttsItplKsSlpsTNcAVpplppuspplshAVpslQDalNsplsPulsphsCchtshplGlpLs....ahoELsolFusplsssu..sslolQALp.Lhuusls.llpshhssphshhpllpothlpGpllsls.pth.hslplslPslsphssshlhch.slShshp...spEhhhplPshlhspus.ltsastss.ChhsspshhCspssu.slssphppC...lpGshosCshohlhushhs+FhhspGsllANCh.uhhCpCsssstsIsQs.spulohIshppCshltlsshphplsp.pspsshhtshslhsu.slslpPlD.lSspLupssppLpsupphlccSsphLsslsstpsotsshlhhlllsslslllhll	..........h.............................hhlcl.s.............th.pt.lt.hpphlppl....tssltt.ptshp....................sstRptRhlGhllGuh............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2631	PF01621	Fusion_gly_K		Cell fusion glycoprotein K	Bateman A	anon	Pfam-B_1083 (release 4.1)	Family	This protein is probably an integral membrane bound glycoprotein that is involved in viral fusion with the host cell [1]. 	19.40	19.40	20.90	20.40	17.90	17.70	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.22	0.70	-5.40	11	89	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	40	0	1	73	0	275.70	43	99.05	CHANGED	hhsspst+lullsllouYhlhllWYss.tsphts..sClYAstshs...sssshsW....................ttaNsoLlYl...shsst..h.sshpshsshCRpsllstsshshhstssslcc+lRhVhtsRNChAYLWpspl+hlsluhhlYhsFlslRppRRMFGshRsss-hlSPssYoLNYAupllSsllL+ssYTKlsRLLsElshpRpuLScsFctDPloFhap+ssshsLlshElhl+luutslshsTlslsasPCuhlaPhal+IhsWlFVuslsslELlull.tscPsptuut........sssssspss..GltulCs...sCCusllSGlhlKslYlshlsssVllhl+YEpclQhpLFG	....h.hhhph.hh.hlhhhosashhhhaYss.hsp..p...ClYAshs.....sst..shhW......................hNpohlah..........sst....sshtshs..Cht.hlttp.hsh.s...shpp+lh.VhtshsChthlW.sphphhhhuhhlYhhFlhh+p.RpMFGshpsttchlsPstYhhNYsspllusshLthsYTKhschLCELSlpRpsLsphFcsDPloFLa++PululllssElhlRhsAhsLlluTshls+ssCAlsYPLalpIhTWsFVuhlulsELhhll...cpssA.csut.........susssscsp.......GhpGVCu...pCCShlLSGIsl+lhYlAllshhVlhhh+YEpplQhtLhs....	2	0	0	0
+2632	PF02663	FmdE	FwdE;	FmdE, Molybdenum formylmethanofuran dehydrogenase operon 	Bashton M, Bateman A	anon	COG2191	Domain	This entry represents the FmdE protein that is encode by the molybdenum formylmethanofuran dehydrogenase operon.  FmdE does not co-purify with the molybdenum isozyme that is formed by FmdC and FmdB [1].  The domain is typically found as a single copy, but is repeated in some sequence two to three times.  It is also common place to find this domain co-occurs with a zinc-beta ribbon domain, suggesting that is may bind nucleic acid and be involved in transcription regulation.	21.60	21.60	22.50	23.50	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.76	0.71	-4.25	188	431	2009-09-10 13:21:47	2003-04-07 12:59:11	9	12	244	4	258	430	25	131.40	25	54.33	CHANGED	pFHGHhCPGlslGh+hsphAhcpL....sh...t......p.........s....cplhslsEss.....s...........ChsDAlQhlsGCThG+..s...sLhhh............ch....GKhAhoh...hscps..sculRl.......h......hp.pthpth.....htth..p........................cppppth..ptlhphs..cclaphpt	........tFHGHhCPGlslGh+huphAhcpL....sh....s........p.................s......cclhslsEss..............s................ChsDAlQhlsGCThG+....u....sLhhp.............ch......GKhuhoh.........hs..cps......sculRl............h.....hcs..pthpth........ph.th..p....................p..pphh.p.hhphs.pphh....h...................................................	0	119	200	228
+2633	PF04186	FxsA		FxsA cytoplasmic membrane protein 	Mifsud W	anon	COG3030	Family	This is a bacterial family of cytoplasmic membrane proteins. It includes two transmembrane regions. The molecular function of FxsA is unknown, but in Escherichia coli its over-expression has been shown to alleviate the exclusion of phage T7 in those cells with an F plasmid.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.35	0.71	-4.50	136	1830	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1809	0	376	1109	1286	120.20	33	73.64	CHANGED	hl.lhlllP..llEIslllpVGshIGhhsTlhLlllTullGshLlRpQGhpsltphppphp...pG.chPuppll.....-.GhhlhluGlLLlhPGFlTDhlG.llLLlPssRphl.tth....ltp+hph...........ts...s.ht	...................................hhhhlhshlE...IslhItVu.p.....hlG.s.h.h...TlhLllhTullGh.Ll.R.s.QGhps..hhphppch.s......tG......c.............P.......u.t.phl............c.ul.hlhlAGl.LLllP.GFhTDhlG.lLL.L.l.Pss.pphl.phh........lh.pht.........tth.tthh......................	0	104	230	311
+2634	PF04799	Fzo_mitofusin	fzo_mitofusin; 	fzo-like conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6217 (release 7.5)	Family	Family of putative transmembrane GTPase.  The fzo protein is a mediator of mitochondrial fusion [1]. This conserved region is also found in the  human mitofusin protein [2].	23.70	23.70	23.80	25.60	23.50	22.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.02	0.71	-4.88	11	189	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	95	1	101	193	1	163.20	50	23.86	CHANGED	hsshspsshopE-hhlshVsulASlTSRoShGlllVGGVlWKolGWRlIsluhulYGsLYlYERLoWTT+AKERuFKpQFVcaAocKLphIVShTSuNCSHQVQQELuoTFARLCpQVDsTppsLp-EltcLspcIppLEslQspuKlLRNKAshlpsELppFpcsa.Lpts	..................................................hs.sshoQEEhMl..ohlouL.ASL..T..SRTS..MGllVVGG...VlWKsVGWRLIulShulYGhLYlYERLTWTT+AKERAFKcQFVpaAoEKLQhIV.ShTuuNCSHQVQQELusTFA+LCQQVDlTpcpLEpEIsplsccI-hL-slQspuKlLR....NKAshL-sELp.Fscpa.Lp..s...............................................	0	28	36	66
+2635	PF01125	G10		G10 protein	Finn RD, Bateman A	anon	Prosite	Domain	\N	23.80	23.80	25.10	25.10	19.90	21.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.99	0.71	-4.64	28	378	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	308	0	261	313	4	138.50	57	91.64	CHANGED	MP+I+p.pp..+tPP-Ga-cIcsoLpcasp+M..................+-Apsps...tc..sc...............p+sEs.........hW.IaplpHpRSRYlY-haY+++...tIS+ELY-allcppYADssLIAKW+KpGYE+LCCL+CIQss-ssau.............................sTCICRVP+upLcps........phlpCspCGC+GCuS	.................MP+l+pt.p..KsPP-Ga-hIEsTLpEhppKM.....................................R-AE......s-s...H-...GK...................+KsEs..........LWPIF+IpHQ+SRYIYDLaY++K...AIS+ELY-ahl+psYADtsLIAKWKK...pGYEp.LCCLRCIQT+-oNFu.............................osCIC.RVPKupLcts.........phl.pC....lpCGCRGCu...............................	0	89	141	212
+2636	PF00503	G-alpha		G-protein alpha subunit	Finn RD, Anantharaman V	anon	Anantharaman V	Domain	G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring  of residues centered on the nucleotide binding site [3]. A Ggamma is  found fused to an inactive Galpha in the Dictyostelium protein gbqA  [3].	48.80	48.80	48.80	48.90	48.70	48.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.31	0.70	-5.78	134	2902	2012-10-05 12:31:08	2003-04-07 12:59:11	15	23	511	117	1599	2617	11	305.60	39	89.11	CHANGED	Mushh.......................................................................................ptpppttppps.p.ph.p.c.p.h.p.pc.ppptp.................pplKlLLLGsGESGKSTlhKQh+llatssas........................pp.EpppapsllhpNllpuhptllcuhpphphsht................................................................................................................................t.ppppptphlhphtsthtp.............................................................................................................................hstchspslppLWp.Dsslppsap..+ppchpL...................tDsspY.................Flsslc........Rlspss..YhPop..................pDlL+sR.l............................pTsGIhEhpFph......................pphpa+hhDVGGQ.RoER+K.WlphF-..................................sVsullFlsuLS-YDpsLhEDpps......................................NRhpESlpLFcsIsssphFp.......sssllLFLNKhDlhccKlpps...lpphFscap............................Gs..sshcp.stpalpppFhphsppp.p........................+plYsH............hTsAs..DTpslphl...hsslp-hI	.............................................................................................................................................................................................................................................................................................t..st..h.p.p.l.p...tp..t...t..........................................................................pth..Kl.L.L.L...........G..s..........GE....S...GKST.......h..lK.........Q..M..+.........Il..H.t..s.G.as...............................pc.-....ttp.ap.hl........hpNhhp..u..h..hsllcAhpplth.ht.....................................................................................................................................p.tpt..psp..l.hth...s.t...t..............................................................................................................................................................................................................................................hs.chht..sl..p...pLW..p.Ds.Gl..p.tsap...R....ppEapL.............................................DsAtY......................................aL..ss..l-........Rl..s.t.s.s..YhP..op......................pDlLRsR..l............................hToGIh..Eh.pFph...........................................................................pplpa.+hhDVG.GQ..RS.....E...R+K..WI..HC.F.-..................................sV.Tu.I.lFhl.......AlS.p..Y.D..s.L..hE...D..p..pt.................................................................................................................................NRhp...EShtLFcoIh..N.s.caFt.......po.SlIL.......FL.NKhDlhpE..Klht..s.....lpth.F..P-Yp........................................Gs..pshpp...Atta.l.....hppF..phsppp.t........................+.lYsH......hTsAs..DTpslphV..FssVpDhI................................................................................................................................................	0	558	822	1230
+2637	PF00631	G-gamma	G_protein_gamma; 	GGL domain	Bateman A, Ananthraman V	anon	Ananthraman V	Domain	G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins [1]. It is also found fused to an inactive  Galpha in the Dictyostelium protein gbqA [2]. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta [2]. All organisms that posses a G-beta possess a G-gamma [2].	22.30	22.30	22.60	22.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.37	0.72	-4.23	50	1212	2009-09-12 06:39:52	2003-04-07 12:59:11	17	17	266	24	681	1015	0	65.80	28	29.38	CHANGED	sphphphtpEl.ppL+p-Lpc..pRl.plSc..AstsllsYsp..sscDshlsss......s.ttpNPatpp..............tss.Chlh	.......................t.....thpcpl.ppL+hclsh..pRl.KlSc...........uut....s....LhsYs-p.....hsppDPllsss.......s.tt.NPahpc....................tts.Ch.........................	0	129	220	399
+2638	PF04466	Terminase_3	G2P; 	Phage terminase large subunit	Waterfield DI, Finn RD	anon	COG1783	Family	Initiation of packaging of double-stranded viral DNA involves the specific interaction of the prohead with viral DNA in a process mediated by a phage-encoded terminase protein. The terminase enzymes are usually hetero-oligomers composed of a small and a large subunit.  This region is found on the large subunit and possess an endonuclease and ATPase activity that require Mg2+ and a neutral or slightly basic reaction.  This region is also found in bacterial sequences [1,2].	22.40	22.40	22.40	22.40	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.22	0.70	-5.38	10	1027	2012-10-05 12:31:08	2003-04-07 12:59:11	8	7	859	2	119	1203	485	355.30	23	85.08	CHANGED	s+papVhhGGRGSuKShslAhplVl+h....hpp...stssLl.lRcltNTlccSlasplp-slspLslschF+hs+Sslpl.phssGup..FhFpGh.DcPtKlKSlc....slsslWlEEAuphpp-s.acpLlsolR......c.thclahSaN.PhscpsWla+pFh..........Dspth........sDshlc+STYpDN...FLscshlcphE-hK+....pNschYRhhhLGEhsssGstlhs...lcshplpssp.tthphshth...........DhGapscssuhlphulch++phlalhs-ahp......sthlccpsu-hl+-.........tphp+cshpu-usEs+ultshcpp.......................thh+hhsu++upsohhpts+hlcpa+sllt..................pscspphIpEhpphpappDcpus.hs....c.hctD.....sHslDAlhYAlcc	..............................................................................................................t...hhlhhGG.RGSuKSh.s....h.uhhh..lhth......hp................s.h.t...hlh..h...RchtsolccSs.app.l.c..sl.p.p...h...u......l....p..c..........h..a..c.h.sp.o..h.c...h..hhss...Gsp.....h.l.FpG.....h....c.........s...s...p..+l..KShp.........sls..hhWh.EEA.....pp..h....pp.ps....aptlh.olR...................p.h....tp....l...a.h.oa...N.P.h.pp...ts..al.cpa.h.............................................................................psshl.hp...ssY....p..DN............a.lsc....hh.p.p.h.-.p.h.p.p................ps.sph.Y.+..h..hh.Gch.h.s.s..ss.h.s..h.................h..pt......h..pt..t........t..t..h..p....h..h.th......................................Dh....G.as....p...c.ss.uh.h..p..h.h...l................p...p.ptl...a..l.....p.-h.h.t...........................th......p...p..t.h..sp.hlhp...........................................................th..t.pt.......hh.uct..s..p......c.ht.thcp....................................hhph.hsspK.s..s..s.h..s.........p....h......l...p.t....h......chll................................ps.phhpEhpph.paphD.pt.s.p..h.........cp.p.........sHhhDAhhYsh..................................................................................................................................................................................................................	0	34	78	95
+2639	PF04309	G3P_antiterm		Glycerol-3-phosphate responsive antiterminator	Waterfield DI, Finn RD	anon	COG1954	Family	Intracellular glycerol is usually converted to glycerol-3-phosphate in an  ATP-requiring phosphorylation reaction catalysed by glycerol kinase (GlpK) glycerol-3-phosphate activates the antiterminator GlpP [1].	21.20	21.20	21.20	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.11	0.71	-5.23	8	1079	2012-10-03 05:58:16	2003-04-07 12:59:11	7	1	949	12	137	527	4	171.60	41	93.62	CHANGED	PllsAl+shcpl-chl-S-hphlhLLsuclssl+pll+hlKs+sKpsFlHlDLlpGLspc.EhuhcFIppthcsDGIISTKuplltpAKKpslhsIQRlFllDSpALcpuhcpltphcPDhlEVLPG.lhP+lIccIsc+oshslIAGGLlcTcEEVcpAL+uGAsAVS.............TSpc..cLWc	..............................................................sllsAl+s.c.sLct.hl.c..o..c.h...ph.lslL..spIsplpsllchl.KpsuKhsFlHlDLlcG.lusc.Ehulpalpp.hcsc.GIISTKushl+pA+phuhh.sIpRlFllDS.uhcpuhc......lpp..sp..PDhlElLPG.sh.P...+.l.lpp...lp..c.ch.p...hP.l..IAGGLIpsc--lppAlpuGAsAloTSppplW.....................	0	64	97	119
+2640	PF00479	G6PD_N	G6PD; 	Glucose-6-phosphate dehydrogenase, NAD binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.70	21.70	22.50	22.30	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.08	0.71	-4.05	117	4951	2012-10-10 17:06:42	2003-04-07 12:59:11	17	21	3884	29	1192	3729	762	172.30	37	36.68	CHANGED	llFGAoGDLA++KLhPALapLhppGhLsps.hpllGhARpcho.c--a+phlcpslpp..........tpphsppthcpFhp+lpYhssshs.sspuappLpptlpch-p....t.ttssplFYLAlPPshFsslsppLppssls..ttp......hsRlllEKPFG+DLpSAcpLscpltphFcEcQIYRIDHYLGKEhVQN	.........................................................llFGuoGDLA+RKLhPuLapLh.p.p.G.h.L.......s.p.p...htll..Gh..u..R..p.c..h.s.....c...-.p..app...h.l.cp.u...lpp....................p..t.h.sppthcpFhp+h..pY.hsh.-.h......s..c...s.p.s.....app.......Ltphlsph....pp..................t.......t................splFYLAhsP.shFsslsppLppss..Ls..........ptp.t.............hsRlllEKPFGpDLtSApcLNsplt.phF..cEcQl...........a.R.IDHYLGKEhVQN...................................	0	344	698	973
+2641	PF02781	G6PD_C		Glucose-6-phosphate dehydrogenase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.50	19.50	19.60	19.60	19.00	19.40	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.96	0.70	-5.56	11	5312	2009-09-10 19:48:29	2003-04-07 12:59:11	11	20	3976	29	1208	3992	928	265.50	41	59.39	CHANGED	LsLRFuNplFsshWNRcsIssVpITF+EsFGTEGRGGYFDphGIIRDlhQNHLLQlLsLlAME+PsShss-sIRDEKVKVL+ulcslssc-V....VLGQYsuu.sGs....ptGYl-DsTVspsSpTsTFsAhhlcIcNERW-GVPFhlRsGKALsp+KuElRlQFKsVstslFcpp...htcNELVIRlQPsEAlYhKhhsKpPGls...hssppo-LDLTYucRa.pshhlP-AYERLILDshpGspspFVRsDELctAW+hFTPlLctl-.scps+PhsY.hGS+GPptuDchhpcsGasascs	................................slRF.AN.s.lFcslW.NppaIcpVQI.............ThuEplGl.E.sRuG.YYDp..s.Gsl..R.DMlQNHlL.................Q..lLs.llA..ME..Ps...s...h....s....s.-....s....lRsEKl.................K..........VL+u..lc....h....s.....t..p.s.l...........hV...RGQY....t..u...Gh............................tu................t......h.uYh-E.....s....l....s.......s.Ss.TE.TFsAh+h.I-NhRWs...GVPFYlRTGKRLsp+s.oclsl.FK.p...s....s....h....s...l.F....tps................hs.Nh....LsIc.....l.Q..P.sE....Glplp..h.....t.....s...K.......P.G..s..................hp..h..p...sp.L-.......h.....s.......h....s.pp................t..........p..h.....p.........s..-....AYE+LlhDshpGstshFs.+.......tDEl.ctuWchlsslhchWt....t.........s.........t....s........................s..Ytu.....Go..........h.GP.tu.thl.t+p.GhtW..h..............................	0	350	709	987
+2642	PF01468	GA		GA module	Bateman A, Finn RD	anon	Pfam-B_895 (release 4.0)	Domain	The GA (protein G-related Albumin-binding) module is composed of three alpha helices [1]. This module is found in a range of bacterial cell surface proteins. The GA module from Swiss:Q51911 shows a strong affinity for albumin.	24.10	24.10	24.10	24.10	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.86	0.72	-3.82	102	9090	2009-01-15 18:05:59	2003-04-07 12:59:11	12	216	256	15	122	9161	0	59.70	37	28.26	CHANGED	lssucssLsGsppLtpAKpsAppplssLspLNssQ+sshpspIssAsolssVsslpspAp	................................VssuKsALN..G.s..p.p....LspA..K..psA.p.p.sls.sLspLNsAQKs.sLpsQIspAs..slssVsslppsAp..........................	0	58	62	119
+2643	PF02938	GAD		GAD domain	Aravind L	anon	Aravind L	Domain	This domain is found in some members of the GatB and aspartyl tRNA synthetases.	21.10	21.10	21.10	21.70	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-10.04	0.72	-3.83	24	4662	2012-10-01 21:10:01	2003-04-07 12:59:11	9	15	4517	16	1094	3469	2015	96.00	34	16.26	CHANGED	Fpsshtp..sGpV+AlplPs..sshoR+pIcthp...chuppaGApGLsal+lps.....tthpuslsKa...lsEpphpplh-pssApsG.DhllhsAsp.tphsspuL	............................Fttshps..tGpVtAlsl...s...Gu......s...phoR.Kp.lDp.hs......ca.s.p..t.a...G..AKGL..A..a.l...KV.s-............ssl...p..u.PlAKF.........l...s.p....-..t......h..ps......lhc......ps..s....A......ps........G..DllhF.sADp.tcllspsh.......................	0	359	705	913
+2644	PF02337	Gag_p10		Retroviral GAG p10 protein	Bashton M, Bateman A	anon	Pfam-B_959 (release 5.2)	Family	This family consists of various retroviral GAG (core) polyproteins and  encompasses the p10 region producing the p10 protein upon proteolytic  cleavage of GAG by retroviral protease. The p10 or matrix protein (MA) is associated with the virus envelope  glycoproteins in most mammalian retroviruses and may be involved in  virus particle assembly, transport and budding [1]. Some of the GAG polyproteins have alternate cleavage sites leading to  the production of alternative and longer cleavage products (e.g. p19  Swiss:P21411) the alignment of this family only covers the approximately  N-terminal (GAG) 100 amino acid region of homology to p10.	19.60	19.60	19.60	21.50	18.50	16.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.96	0.72	-4.24	5	102	2012-10-01 20:35:47	2003-04-07 12:59:11	12	13	32	2	27	135	0	88.40	37	14.18	CHANGED	MGSopSc.pLFVotLpcsLKpRGl+V+cscLlsFasFlc+VCPWFPpEGolslcsW+RVG-plccYYspHGPEcIPlsTauaWsLIRDlL-	.................GpphSp...alphLphhLp...pRGlpVppssLlpFhphlccssPWFPcEG.T.lsLcsW++VGcpl+pahsh+Gs-pIPlpsashWsll+-hLp..................	0	11	11	11
+2645	PF00540	Gag_p17	gag_p17; 	gag gene protein p17 (matrix protein)	Bateman A	anon	SCOP	Domain	The matrix protein forms an icosahedral shell associated with the inner membrane of the mature immunodeficiency virus.	20.80	10.00	20.80	16.00	20.30	9.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.74	0.71	-4.41	3	37754	2012-10-01 20:35:47	2003-04-07 12:59:11	13	30	106	33	0	27496	2	123.20	74	36.45	CHANGED	GARASVLoGGcLD+WEKIRLRPGGKKKYplKHLVWASRELERFAlcPGLLETcEGC+KILpQLpPuLpTGSEGLRSLYNTVAVLaCVHQ-IcVKDTcEALEpl+ccpscscKK..TtssssuuQQuAusGGTusSuGlSQNY	..........................GGc..LD.tWEKI...RL.RPGGK.K+Y+LKHlVWA.....S....R.ELERFAlNPG.L.LETo.EGC+QI...ltQ.L.QPuLQ.TGS..EE.L+SLaNTVATLY..C.V..HQ+I-VKD.TK.EALDKIEEEQ.N....KSKpK......................s...Q....Q...us...u..s............s..u...s..s...u...p...V.S.QNY......................................	0	0	0	0
+2646	PF02228	Gag_p19	gag_p19; 	Major core protein p19	Bateman A, Mian N	anon	Pfam-B_1307 (release 5.2)	Family	p19 is a component of the inner protein layer of the viral  nucleocapsid.	20.80	20.80	26.00	23.50	18.50	16.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.19	0.72	-3.68	2	75	2012-10-01 20:35:47	2003-04-07 12:59:11	11	10	18	1	0	77	0	83.90	64	15.89	CHANGED	MGphaSpsAsPIP+sP+GLAhHHWLNFLQAAYRLpPGPSpaDFHQL+KFLKlAlcTPshlsPINYSlLAuLlPKsYPGRVpEIltILIQpps	...MGphau.ssoPIP+sP+GLusHHWLNFLQAAYRLpPGPSsaDFHQL++FLKlALcTPlWlsPINYSlLASLlPKGYPGRVsEIlpILIQsQ..............................	1	0	0	0
+2647	PF00607	Gag_p24	gag_p24; 	gag gene protein p24 (core nucleocapsid protein)	Bateman A	anon	Bateman A	Family	p24 forms inner protein layer of the nucleocapsid. ELISA tests for p24 is the most commonly used method to demonstrate virus  replication both in vivo and in vitro.	20.70	19.70	20.70	19.70	20.60	19.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.36	0.70	-4.78	16	45086	2012-10-02 13:14:50	2003-04-07 12:59:11	15	80	305	153	68	32172	2	179.20	82	55.09	CHANGED	.+pLpthhpslcp.uhsustslshhpulupsh..sshDhpphLss..ss...sptus.hpll+st...lsEpstchcpsp..s..sshs........hss-.IhGsGs..spppptphths.....sltpphpphhltAhp+lsphtsss.shhsl+QGPcEPYpDFVsRLhpslcsp.sstcsKphhhcpLuhpNANs-Cpphl+slt....hpuoL.p-hlpACpslGustpKuplh	...................................................................................PRTLNAWVKVlEE.KAFSPEVIP.MFoA.L.SEGA...TPQDLNT.ML.NT..VG...GHQAA.MQMLK-T......INE..E......A.AE..WDR.lHPVH..AGPlAPGQ...MREPRGSD.IAGTTS....TLQEQIuWMTsN.....PPIPVG-IY.K.RWIILG...LNK...I..VRM.YSPs..SILDI+QGPKE.PFRD..YV.D.RFaKTLRA...E..Q.A....oQ-VK.N.W.M.T-TLLV.Q....N.A.NPDCKT.I....L+.A.LG....PuATL..EE.M..........................................................	0	11	11	17
+2648	PF02093	Gag_p30		Gag P30 core shell protein	Bateman A	anon	SwissProt	Family	According to Swiss-Prot annotation this protein is the viral core shell protein. P30 is essential for viral assembly [1].	20.40	20.40	20.50	21.50	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.58	0.70	-5.12	6	261	2012-10-02 13:14:50	2003-04-07 12:59:11	11	22	75	32	46	311	2	181.30	63	26.71	CHANGED	QYWPFSuuDLYNWKopNPsFScDPsuLTuLIESlLhTHQPTWDDCQQLLQsLLToEERQRVLLEARKsV.GssGRPTQLPNEID-uFPLTRPcWDYsTAtGRE+L+lYRQhLLAGL+GAuRRPTNLAKV+pVsQGssEoPSAFLERLhEAYRhYTPaDP-sPGQpAsVuMSFIhQSAPDI+pKLQRLEGLQsaoLpDLVKEAEKlYNKRET	.........QYWPFSSSDLYNWKsNsP.sFSEDPtcLT.........uLlESlhhTHQPTWDDCQQLLtTL.hTsEE+pRlLLEARK.....sV.GsD.GRP..T..QLs..NE...l...stuFPLp.RP.sWDYs.T.scG.R.ppLhlYRQhLlAGL.psAuRpPTN.LAKV+tlhQGssEsPSsFLERLhEAaRRaTPaDPps.uQcss..Vuh..uFIhQSA.DIt+KLpRLEsLpptpLtDLV+EAE+la.+RET........................................................	0	4	4	12
+2649	PF03276	Gag_spuma		Spumavirus gag protein	Mifsud W	anon	Pfam-B_1878 (release 6.5)	Family	\N	19.60	19.60	19.90	19.90	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.99	0.70	-6.18	7	132	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	16	0	1	105	0	287.50	61	96.65	CHANGED	MAt.....p.-LDs.tL.sla.s.Gl.ppP.Ht-lIulRhTuG.WG.u-RaphVplhLQDs.sGQPLQ.Pcac..s.RssNPtsp..hlluuPaspLRpAFpsl-lucGs.RaGPLusGpa.PGDtYSppFpPls.pEhAQhptpcLEp............lshlthtchEIRhLRp.h.chph...tGhssslPsAsts.PP..s..t.....................................................................P.p....PsA..........hPsPshsPhl..sssP.....PhPssp....IPIpHIRAVhGpsPsNPR-lPhWLGRsssAI-GVaPhsssshRsRllNALluup.GLsLps.-ssoWsuAlAsLahRTaGuhslHpLusVLpuIAspEGVssAapLGhMhospsasLVWGIlRshLPGQAlVsshQpRLDt.ssDtsRhtsF.phlpsVYplLGLNs+GQSlp....hsposptps.uputGRGppu.csp..........pppppGRppspssptQpsp.ps.ssQp..Qppsssps.ptp.GGYsLRPps.QPQRYGuGpGpt.Ns.......pPhRpsspspspppps.s...sRG.sQScssussttpGGRtspsRNppuussssop	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................AIDGVFPlTTPDLRCRIINAlLGGNLGLSLTPuDClTWDSAVuTLFlRTHGpaPhHQLGsVlpGIsNQEGVATAYTLGMMLSGQNYsLVSGIIRGaLPGQAVVTAhQQRLDQElDDQARAETFIpHLNAVYEIL.GLNARGQSIR.....ASVT.sQPRP.SRG.RGRGQstsRPSp.........GPAsSGRGRQRPAs.GQ.-RGSNsQNQs..QuNsuQ................................................................................................uGh.................................	0	0	1	1
+2650	PF00337	Gal-bind_lectin		Galactoside-binding lectin	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family contains galactoside binding lectins.\	\	  The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	22.10	22.10	22.20	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.79	0.71	-4.81	80	2093	2012-10-02 19:29:29	2003-04-07 12:59:11	17	35	209	254	1005	1892	5	132.10	26	57.70	CHANGED	shhtsl.sssh.ps...GpplplpGhst..................sss...................spFplNltss............psslslHhNsRasp........sslVpNo..hhsus..Wu..p.EER...........................................................tshPFppGp..Fplplhsp.pcpaplhlNstphhpFtaR..hs...pplst.lplpG..Dlp.lpslph	............................................................l..su.l.ts...GpplhlpG.ps...................ss..............................................pp.Fplsltss..............ts-lAhHhNP.RFsp..................................stlVpNo...hhssp....WG..p..EER................................................................t.t.t.h.PF..p....p.Gps...F........c.......lp........lhs..p..pp.pap......l...hV.sG...pph...h...patHR.......hs.........pplstl.p....lpG...Dlp.lppl..h...................................................................	0	188	321	655
+2651	PF03902	Gal4_dimer		Gal4-like dimerisation domain	Finn RD	anon	DOMO:DM03802;	Family	\N	21.10	21.10	21.30	21.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.62	0.72	-4.03	4	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	49	6	40	99	0	49.00	39	7.09	CHANGED	TRAHLTEVEsRlupLEQlL+.lFPchDlDplLpp+cp.pl+tlLp.htsosslst.u	TRAHLTcVEsRLppLEplhtpLFP.s....t....-lDt....lL....p.....p..........................................	1	6	23	36
+2652	PF01762	Galactosyl_T		Galactosyltransferase	Bashton M, Bateman A	anon	Pfam-B_885 (release 4.2)	Family	This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferas e Swiss:O43825 [1] and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase  Swiss:O54904 [2].  Specific galactosyltransferases transfer galactose to GlcNAc terminal  chains in the synthesis of the lacto-series oligosaccharides types 1  and 2 [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.29	0.71	-4.71	14	2182	2012-10-03 05:28:31	2003-04-07 12:59:11	16	34	186	0	1505	2219	31	177.90	24	47.89	CHANGED	sRRsslRpTWhspp...h......sclptlFLlGhss.t-t+hcchlhpEu+.hYGDllhs-hpDsYpcLsaKoLshhhausopsPpschIsKlD-DVhh.sspLhshLtpt...hssp.psthYGhlh.psGhshtpcps+.............Wahs.psasssp..............assYsuG.hYllotcAsptlhpsoc+p.pahplEDshl.GlhApchslshhsh.	.......................................................................................pRpslRpTWhttt....t.....................................htl...h..h.hFl..............l....G....t..s....s..............................s............t............p............h..p...p..................l..p....t.Esp.ta.s.D.l..l.....h..s....a...h.D..s.Y.tN.L...o.h...Ks....lh............h...h.............pas....s....p.......h..............s..........s............t.........s..c....a.lhK.s............DDDs.al.sh.spl...lp...hLtph................................p...p...p...........h..........h.....h......u.......th.....h.......p........t....t......s..........h..p..p........t...s.K..............................a.a..h..s...p..a.......s.h..............................................Y.P.sa.s.s.G.............s................uYl.hStsls.p.h.l.....h....t.....s..s...........t.....p........h.....p.h...........h...........h........-D.Vhh.Ghhhtt.h.t.l......t......................................................................	0	563	798	1152
+2653	PF02709	Glyco_transf_7C	Galactosyl_T_2; Glyco_transf_2C;	N-terminal domain of galactosyltransferase	Bashton M, Bateman A	anon	Pfam-B_834 (release 5.5)	Family	This is the N-terminal domain of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.64	0.72	-4.51	98	1328	2012-10-03 05:28:31	2003-04-07 12:59:11	9	46	442	59	697	3197	601	76.40	28	20.10	CHANGED	pph..ssshsphphph.a.pphhGGlhuhppppahplNGas..NpaaGWGuE.DDDhhtRlhtpsh..p...............lpR....shshst.......a+hh....H.......p	...........................................h.h..tt..h.h.GGlhuls+pp.F..h..pl....N.Gas...spa.h...G.W.G.u.E.Ds-h.h.t...Rl.hh..s.G.h..p..........................lpR.....p.h.phst..........a+hh...H.tp..........................................................	0	242	317	501
+2654	PF01296	Galanin		Galanin	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.90	21.20	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-7.15	0.72	-4.11	4	94	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	41	0	35	88	0	24.10	73	25.87	CHANGED	GWTLNSAGYLLGPHAlDsHRSFsDKHGLA	..GWTLNSAGYLLGP+AlDsHRSh..tDK.Ghs......	0	2	5	10
+2655	PF02052	Gallidermin		Gallidermin	Mian N, Bateman A	anon	IPR001049	Family	\N	20.20	20.20	20.20	20.60	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.53	0.72	-3.84	3	129	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	89	1	5	51	1	45.90	56	90.42	CHANGED	MEAVKEKNDLFsLDVKVNAKESNDSGAEPRIASKFLCTPGCAKTGSFNSYCC	.........h-........clhDLDVpVKus..s.sNDSuuDp..R..ITS+SLCTPG.Ct..K..T..GSFNSaCC............	0	1	2	2
+2656	PF02744	GalP_UDP_tr_C	GalP_UDP_trans_C; 	Galactose-1-phosphate uridyl transferase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports fold duplication with N-terminal domain.  Both involved in Zn and Fe binding.	29.20	29.20	29.30	29.40	29.10	28.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.15	0.71	-4.71	9	2558	2012-10-01 23:45:21	2003-04-07 12:59:11	12	9	2265	12	565	1810	220	176.00	32	43.44	CHANGED	E.........cpa.cYhttp........GShLhhDYsp.......hEltct-RlVh.s-p.alsVVPaWAtWPapsLlLs.+c+lhpls-Lsst..........pppDLAu........hl+plsp+YDNLFE.........TSFPYSMGlHtushsspts...tth.hHsHaYPPLLRSATVRKFhV.GaElLupsQRDlssEQAAt+L+..........sLs.phHhchsh	...........................................................................th..c...tYFttp............GS.LhtDahQ...............................hE.hA....s....t..pRhlht.s.-...ahsVs.shhs.pWPhpslhLs..pp.c...hpcls-Ls-p.....................ppsslst................slp.lsp.+.h.D..s.h.F.p...............................sShsYshGh............................................................hH..sH..h..s...h.l.+.pt.s.lt..hh.V.G.h.t.h.L.s.tp....+.-.htE.us.hLp..................tls..thH.t...t..............................................................	0	171	324	461
+2657	PF01087	GalP_UDP_transf		Galactose-1-phosphate uridyl transferase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports fold duplication with C-terminal domain.  Both involved in Zn and Fe binding.	22.10	22.10	22.10	22.30	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.35	0.71	-4.23	135	2821	2012-10-01 23:45:21	2003-04-07 12:59:11	17	13	2385	22	659	2041	370	183.20	28	46.17	CHANGED	s.ths.p-p.......................................sphRhssLhuphll..............suscp.................tcR..satspppth.tsshsptD.......hshLsPssscl....ssp.hsspY..psshshsNcFhuLpp.csshhpp..........scs..................hapspsshG.phcVhh.tsc.p...............p-hcslsssh.tphtp.........p......................th.phl.saENcGhthus......o..HP.............................Hu.lasppalP	................................................................................s..h...Dp...sp.RhtsLh.Gphll...............................susct..........................tc+........sht.s...tp...tt....pp.h.s.sp-................shls........Ps......s.....s..........p.....l..............stp.....h..................ssY...........psshhhs...s......c............FhsLtpcs.s.ht.p....................................sps................................haps.pss.hG..phclhh.psc.p................pchcplsts...phsc.....h..p.....................................h.thl.saENcGhthG....s....o.......HP..................................Hu.lhsspalP..........................................	0	214	398	548
+2658	PF00304	Gamma-thionin		Gamma-thionin family	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.49	0.72	-3.95	50	545	2012-10-01 23:31:40	2003-04-07 12:59:11	15	2	132	17	121	592	0	46.80	35	59.18	CHANGED	+sCcstSppF.+GsChssss..CspsCpp..Esas...uGcCct...hpRR.ChCo+.C	................hCcs..Stpa...cG..s.C...h...s...sss..CsshCps........E...sas...uGpCph......pp+.CaCpt.C............	0	27	58	87
+2659	PF04410	Gar1		Gar1/Naf1 RNA binding region	Kerrison ND	anon	DOMO:DM04007;	Family	Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation [1]. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex [2]. In humans, Gar1 is also component of telomerase in vivo [3].  Naf1 is an essentail protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1 [4].	29.30	29.30	29.50	29.50	29.10	29.00	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.62	0.71	-4.77	57	687	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	360	15	496	691	25	146.10	25	42.52	CHANGED	sp.hhcthhst...shshs..ssspl..lGph.pss-sp....lllcusss.......pV.phsuhlh.hEs+s.l.GplsElhGslpsshasV+.......sppthpst..shphGsplahsss....hph.hhspshtt....+Gscuusttccchs..tttt.pauccctptth+pttptp+	...................................................................ttt....tth...h....t.h.p.s..sstp..l..h.lGph.p......hs.-.s.p....llscuhss..........pl..hsusla..h-...s.+.p...l.G+VsElhGslppsaaol+..................s-slpsp.....uh..p..hGsp.hYhssp....................hph.hhsp.hht.....................+Gsctut.ttstpss........tth.t.aus.sttt.tthtttht...t..................................................................................................	0	175	287	416
+2660	PF01071	GARS_A	GARS; 	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_916 (release 3.0)	Domain	Phosphoribosylglycinamide synthetase catalyses the second step in  the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the ATP-grasp domain of biotin  carboxylase/carbamoyl phosphate synthetase (see Pfam:PF02786).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.14	0.71	-4.74	19	4769	2012-10-10 13:17:03	2003-04-07 12:59:11	14	45	4503	19	1247	7505	5005	188.90	49	41.23	CHANGED	uSKsFsKcFhp+asIPTA.pYcsFo..c.sccApualcctshss.....VVKAsGLAAGKGVlVs....psp-EAhpAlc-lhtpttFG.pAGcpVVlEEhL-G-ElSlhshsDGcolhshssAQDHKRlh-GDp...............................GsNTGGMGAYu....PsPhlopclhcplhcpIlpPTlcuhtcEGhsapGlLYuGlMlo.csG......PKVlEFNsRFGDPET	....................................................GSKsFuK-hM.t.+as..IP...TA...p..............Y....p..s..F...s........-......hc...p...A...h.....s..Y...l.c...p...t...G.sPl............VlK...A...D..G.L..A.A..G..K...........G...........V...l....VA...................o...h....-...E......A....t....p....A...l......c...c...h....h.......t.......s.......p.......t.......F.........G..........s.....A....G...p.........c.....V....V.I.EE.F.L....-...G...-..E..hS..h.hs..h..s...............D.........G........c.....p...h.l....P.h..s.s..u.....Q....DH.K..R..l..hD...GD.p.......................................................G.P..N.T.....G.G.M.GA.Y.o....Ps.P.h.l........o....p...........p..........l...........h.p..c.sh.cpIlpPTlcG.Mt.p..E.....G..p..sap.G.l.L.YAGLMls..psG..........PKVlEFNsRFGDPET................................................................................................................	0	403	790	1057
+2662	PF02843	GARS_C		Phosphoribosylglycinamide synthetase, C domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_916 (release 3.0)	Domain	Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the C-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see Pfam:PF02787).	21.80	21.80	22.80	21.90	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.90	0.72	-3.81	94	4668	2009-01-15 18:05:59	2003-04-07 12:59:11	11	41	4494	19	1219	3584	1998	93.10	39	20.27	CHANGED	sulsVVlAutGY......Pts..p+.Gh.lsh....t....ttpsshlFaAGo...................p....................tp..ss...............pllosGGRVLslsuhusolpcApppuYpslppl..phs.shaYRpDIGt...+sh	......................................................ulsVVlAutGY......P..s....s....Yc....K...Gs.IsG......................ttstsstlFHAGT....................................p........................................hp...ss.................pl.lT..sG..GRVLslsu..hG.colp-AppcAYp.tl.s.p..I.pa......c....u......haaRpDIGh+A.h........	0	384	769	1030
+2663	PF02844	GARS_N		Phosphoribosylglycinamide synthetase, N domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_916 (release 3.0)	Domain	Phosphoribosylglycinamide synthetase catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by Phosphoribosylglycinamide synthetase is the ATP- dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide. This domain is related to the N-terminal domain of biotin carboxylase/carbamoyl phosphate synthetase (see Pfam:PF00289).	24.30	24.30	24.30	28.30	24.00	24.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.21	0.72	-3.54	135	4637	2009-01-15 18:05:59	2003-04-07 12:59:11	10	33	4461	19	1204	3558	2108	100.50	48	21.94	CHANGED	M+lLllGuGGREHAlAhpL.tpSsplsclasAPG..NsGh...uph..ups....hsl........shsDhssls..paApcpslDLslVGPEsPLssGlsDthpp....tG......ls..lFGPoptAApLE	.......................................M+lLVlGuG.GREHALAaKl....spS...s...p........V.....c...p.lalAPG....Nu.Gh.......ut....u..p.s.........lsI.........shsDhsuLl.......sFAp..cp..pl-LslVGPEsPLl..t..GlVDsF..cs......s..G.....lp..lFGPopsAApLE................	0	383	758	1019
+2664	PF03198	Glyco_hydro_72	GAS1; 	Glucanosyltransferase	Mifsud W	anon	Pfam-B_2209 (release 6.5)	Family	This is a family of glycosylphosphatidylinositol-anchored beta(1-3)glucanosyltransferases. The active site residues in the Aspergillus fumigatus example Swiss:B0XT72 are the two glutamate residues at 160 and 261 [3].	25.90	25.90	26.20	26.30	25.50	25.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.10	0.70	-5.44	12	708	2012-10-03 05:44:19	2003-04-07 12:59:11	9	14	163	3	511	679	10	297.50	41	61.20	CHANGED	ssstutsss.sIpIhGN+FF.ops.......uppFaI+GVsYQPssSt...........SshsDPLADsc..sCpRDl.hhppLGlNTlRVYulssotsHDcCMphLpsAGIYlILDLssP..spSIsRtcP..oaNsshhpphhssIDsFpsYsNlLGFFAGNEVsNstssos..ussaVKAslRDhKpYIps+saRpIPVGYSAsDssssRlphAcYFsCGs.s...............s..+uDFaGhNhYEWC.Gt.SoapoSGYcs+sc-FcsasIPlFhSEaGCN....cVp.......sRsFsEVsslYSspMosVaSGGlVYpY.pEsNsYGLVplsssssp.hhsDFpsLKpphtplu	..........................................................ss.....sslssIplp..Gs..cFa..ps................GppFal+G...lsYQ.ssu...............................sshhDPL..uD..s..p..sCpRDl..shhpcLG..sNsIRVYslDsst..sH-cCMph.Lsc...AG...IYllhDlssP.........stSI.sR............s...s...P..................sass.shhpphhsllDtFupYsNsLG......FFuGNE....V..hNst.ss....os.......uusa...V.KAssRDhKpYIp....s..+..s.....h..Rp.IPVG.YSu......sD....s..........s.........p..h.R...phup.Y........hsCusss..................p...psDFaGhN..s.YpW..C...G.s....S..o...a....p.....s..S......GYsphscpF..p..s..a..s..lPlFFSEYGC....N.......p.sp.............PR.FsEltA.lY.....u.....s.....p.MosVa....SGGlVYpYh...pE...s....N...s....Y.....GLVp...l...s.s...s...s..s.h.....hhtDaptLppphtp..t.........................................................	0	101	260	432
+2665	PF02187	GAS2		Growth-Arrest-Specific Protein 2 Domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.59	0.72	-4.21	4	597	2009-01-15 18:05:59	2003-04-07 12:59:11	12	116	140	1	314	529	5	69.70	52	2.76	CHANGED	cpl-DtV+Rlltp..CpCsp+FpV.pluEGKYRhGDSphLhlVRlLRSpVMVRVGGGW.sL-caL.KpDPCRspp	................................plc-tVp+....ltp....C........pCsp....+.Fp....l.ppl..u..-..sK............YR..............h.........G...D.o..p..tLhll..Rl..L.R..o..p.VMVRVGGGW.sL-cFL.s.K...pDPCRsp.t......................	0	92	125	199
+2666	PF00741	Gas_vesicle		Gas vesicle protein	Bateman A	anon	Pfam-B_545 (release 2.1)	Family	\N	25.00	25.00	26.40	30.10	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.58	0.72	-4.08	52	505	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	154	0	197	506	18	38.70	48	35.03	CHANGED	uLsDlLDRlLDKGlVIsuDlplSlusl-LlslclRlllu	..uLsDlLDRlLDKGlVIsu.lplSlssIELLsIclRlllA.	0	71	157	191
+2667	PF01304	Gas_vesicle_C		Gas vesicles protein GVPc repeated domain	Finn RD, Bateman A	anon	Prosite	Repeat	\N	20.50	20.50	21.90	21.90	19.90	18.20	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.90	0.72	-7.35	0.72	-4.32	19	227	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	48	0	5	187	0	32.40	49	53.18	CHANGED	hppLpppTpcFLosTsppRhAQAcpQAppLppF	....ppLQppoppFLosTAptRhAQAccQApELhpF.	0	0	5	5
+2668	PF02704	GASA		Gibberellin regulated protein	Bashton M, Bateman A	anon	Pfam-B_1221 (release 5.5)	Family	This is the GASA gibberellin regulated cysteine rich protein family.  The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have some role in plant development. There are 12 cysteine residues conserved within the alignment giving the potential for these proteins to posses 6 disulphide bonds.	21.60	21.60	23.60	23.30	19.70	18.90	hmmbuild  --amino -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-9.96	0.72	-4.00	41	346	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	59	0	171	350	0	59.70	52	54.40	CHANGED	pCsspCstRCSposh.+chChphCspCCt+Ch.CVPPGTYGNKphC.PCYsshKT+pG...tsKCP	.........pCsupCshRCStsuh...pc...hChchCspCCt+Ct.C...VP.PGTa.G.NK......c..tC.PCYsshpT.+pG...psKCP.........	0	15	111	144
+2669	PF00918	Gastrin		Gastrin/cholecystokinin family	Bateman A	anon	Pfam-B_1542 (release 3.0)	Family	\N	22.20	22.20	22.20	23.80	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.78	0.71	-3.28	11	170	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	67	0	55	185	0	103.10	35	96.97	CHANGED	tsslClslllsVLusushscssshsc......sthpp............ssptthpshpptp........csctshuulhp+hLtttphst.huchushps.htpp-stcthtD+DYhGWMDFGRRSuEEh-hsu	......................tlslslLlssLu.h.u.shupss..sp........thtp.......................t..s.tt.psht..t.....................csctshuuhLsRhlpt.ttpst.su.cho.hhps.h.p.-..sat.tp.pDYhGWMDFGRRSAEE.-.................	0	3	7	20
+2670	PF00310	GATase_2		Glutamine amidotransferases class-II	Finn RD, Bateman A	anon	Prosite & Pfam-B_5381 (Release 7.5) & Pfam-B_455 (release 7.6)	Domain	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.22	0.70	-5.75	57	7459	2012-10-03 21:14:07	2003-04-07 12:59:11	16	48	3746	79	2152	13504	10212	226.90	25	23.73	CHANGED	CGl.Ghlsphpspso+.pllppulpuLpplpHRGuhss-.psGDGAGIhh..phPcphh.........th.h.......usu.hah...............t.hpt.h.t.s..lhuaR..lPht.t.hu..s...tt.P.h.Q.hlt..................................thc.pLahhR+.phpp......phttpt..........hYhsShs..sllYKG.hhs..l..a.a.DLps.phposhulsHpRaSTNThPsW.hApPhR.........hluHNGEINTlpGNpsahp..u+pthh..po..h.......t.h.Ph...t.............................................................................................................................sSDSsshDss.lEhhhtsG.hp...shhhhlP.sh..tp.ths....phpsFaca..hsslhEsWD..GPsulsh....o...D....G+...h..luAslDRNGL.R...PuRasl.T..............cDs...h.llhuSEs	......................................................................................................................................CGh.uhl................pp...plh.p.hh.phL.phpaRGh..........DusGlhh.....stt.h.................................................................................................................................................................................................................................................................................................................................................................................................h...a....th.t.........t..h.....u.t.....h...sl.hH...Ra.sT.s...s.............s...p..h......A.pPhh.................................................hlsH.N..G.......pls.s..hp.....t...hp.h...h....t..p.t.h...h...ts...........................................................................................................................................................................................t.S..D.o.t.............h......p.h.h.t.h...h...th............................................................h............t..p.sh..aph.....t......h...h..p.....h..c.......G...sh...s.h.s.h......................Gp............h..h..s.....h.D...p..Gl...RPhhhhhp..............tpt.......hhhuSE..................................................................................................................................................................................................................................................................................................................................	1	614	1255	1761
+2671	PF04572	Gb3_synth		Alpha 1,4-glycosyltransferase conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4980 (release 7.5)	Family	The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilise UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region [1].  	20.40	20.40	20.70	20.50	19.10	20.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.88	0.71	-4.47	17	301	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	96	0	207	294	11	127.30	29	35.50	CHANGED	hsF-sp...HplsttClc-hspsaNGspWGpNGPtllTRVl.+hhCpspshtthpp...pCht.holhsPsAFYslsa.pacpaFcs.ptcpshphlp........pShslHLWNKho+..shhlc.GSpshhthLhppaCPpsapustphh	...............................................hFp.p...H.hhthshc-FsppY...sup.hWGp...pGPtLlTRVh.+phCshp..sh.t..t...........tChs...hshlsspsFYPlsap.cacc.aF.cs.psp..p..t.h....p..h...hp......................so.YulHlWN..+hop..tht.hch.s.Sp.lhtpLhppaCPtsht.h....h.....................	0	63	97	152
+2672	PF02263	GBP		Guanylate-binding protein, N-terminal domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4308 (release 5.2) & Pfam-B_9065 (release 8.0)	Domain	Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.66	0.70	-5.33	13	1135	2012-10-05 12:31:08	2003-04-07 12:59:11	14	37	152	19	688	1289	39	218.70	30	40.25	CHANGED	cppLtlNpEALcIL....psIoQPVVVVAIVGhYRTGKSYLMN+LAG...........................pppGFSLGuTVpS-TKGIWMWClP....HPspPchTLVLLDTEGLtDhEKuDs+sDuWIFALAlLLSSTFVYNShsTIsppAL-QL+hVTELTchI+u+ss...t.sclcsussFVuFFPsFlWTVRDFoLpLEh-GpslTsDEYLEpuL+LppGpstclQs.N.sRcCIRpFFPc+KCFlF-+PutctpL.splEplp---L-s-FppQlppFsSYIao.cuhsKTL	..............................................ph.ls..p.A..lphl.............ph..h..s..p.s...l...s.VV......ulsGhaRpGKSaLhs.h.h..h..t................................................................p..G.F..sh..t.s.......ss....p...s..p..Tp.G.Ih....h.W..s.s...........................ps.p...t.....p...h.s.......llLlDT..pGhhs....p.....p....u.s...........p....s.............s....s..hl..FAL.u...s..h..lSS..h...l.YN........t.s....I...pp.p..s....lp.p.L...........p..h............ho-.........................................................st..h..t......p...t............h.............p............F..........s.hhahl.RDa..s.h....h..c.h..s.h.t...............s..tp.....p.a.L......-p..t...L....p...h...................t.....p..p.......p....h..p...p.........R.tp.......l..pphF..s.phpCFh..hspPs.ph.th.........ph..ct......t..pplp.pFhp...pht.h...h.hlht..t........................................................................................................................................................................	1	260	347	485
+2673	PF02841	GBP_C		Guanylate-binding protein, C-terminal domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4308 (release 5.2)	Domain	Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.72	0.70	-5.23	23	678	2009-01-15 18:05:59	2003-04-07 12:59:11	9	20	96	9	366	663	7	220.50	29	37.66	CHANGED	GGIhVoGs+LusLVpTYVsAIsSGslPClENAVlsLAQhENoAAVQKAlsHYpppMuQ+l.phPT-TLQELL-lHpssE+EAIpVFMcpSFKD..csQcFQKcLhspLcsK+c-FhcpNp-ASscpCpslLpcL.psL-cslppGsFStPGGapLalcc+cclcpcYpps...PcKGl+AcEVLQpF..LpS.......................+c.slpcoILQoDpuLTcpEKpIpsE+s+sEuAEtcpchLcpcpccppphMEsp-+SapEpl+QLpEKMEpERc.plhpEpc+hlppKLpEQcchLpEGFcpcucpLppEIpcLp	..................................GhpVsGp.tL.h.plhpsYlcslsu.G.s.l.Pshcssl.ulAphcNpuAVpcAhshYpppMpphh......p........hPh.p.......s....p.-.L.chH.pts...ccc.AlplFh...c...p...u.h..p..D.......s...p...p.......a..p.c.p..Ltpp.l.ccph..p..........s..F..............hp.pNpptu......thCpt...ht.........h.....h...............................h...................h..................................................................................................................................................................................................................................................................................................................................................................................................................................	0	107	154	219
+2674	PF02425	GBP_PSP		Paralytic/GBP/PSP peptide	Bateman A	anon	Pfam-B_2690 (release 5.4)	Family	This family includes insect peptides that are short (23 amino acids) and contain 1 disulphide bridge.  The family includes growth-blocking peptide (GBP) of Pseudaletia separata and the paralytic peptides from Manduca sexta, Heliothis virescens, and Spodoptera exigua [1] as well as plasmatocyte-spreading peptide (PSP1) [2]. These peptides function to halt metamorphosis from larvae to pupae.	25.00	25.00	31.00	42.20	20.00	17.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.43	0.72	-6.85	0.72	-4.42	3	25	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	15	11	3	34	0	22.90	81	27.38	CHANGED	ENFAGGCsPGYhRTADGRCKPTF	.ENFAGGCssGYhRTADGRCKPTF.	0	2	3	3
+2675	PF02526	GBP_repeat		Glycophorin-binding protein	Bashton M, Bateman A	anon	Pfam-B_1047 (release 5.4)	Repeat	This family contains glycophorin binding proteins from P. falciparum the malarial parasite [2]. Glycophorin is a cell surface protein of erythrocytes. The Glycophorin binding protein contains a tandem 38 residue repeat. In Swiss:P02895 the repeat occurs 11 times.	25.00	25.00	102.50	43.00	18.50	16.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.67	0.72	-4.56	9	59	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	4	0	24	67	0	37.70	83	63.70	CHANGED	TSADPEGQIM+tYAADPEYRKHlpVhYpILTNTDPNDE	.TSADPEGQIM+tYAADPEYRKHLpVhYpILTNTDPNDE.	0	24	24	24
+2676	PF04551	GcpE		GcpE protein	Bateman A	anon	Pfam-B_1482 (release 7.5)	Family	In a variety of organisms, including plants and several eubacteria, isoprenoids are synthesised by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway [2].	32.00	32.00	36.10	36.80	30.10	30.70	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.12	0.70	-5.65	45	3640	2009-09-10 23:01:59	2003-04-07 12:59:11	9	7	3355	8	908	2655	3339	344.20	45	91.10	CHANGED	TRpVpV..Gs......VtIGGssPIsVQSMTs...TcTpDlcuTl....pQIpcLtcAGC-lVRluVsshcsAcAlppI+cp.....hs.lPLVADIHFs.a+lAltA...h-tul-KlRINPGNl.......................up.c-+hctlVctAK-pslsIRIGVNuGSL....pcclhp+Y.......tsTsc...uMVESALcalclhEchsF..pclllSlKuSclhhhlp.AYRhlupcs-.......YPLHLGVTEAGshhsGplKSulGlGsLLt-GIGDTIRVSLT...s-Psc....El............................................................................................................................................................................................................................................................................................................................................................................................................pluhcILpulsL.Rptus........clISCPoCGRs.thDLhplspclccplp..plc..........sl+lAVMGClVNGPGEuc-ADlGlu.uGpGp...uhlac+Gchl++s.sp-phl-cLlc.Iccht	.............................................................................................................................................pplhVGs......VslG.u......s......uPlsVQSMTN.......Tc.TpD.lp...ATl....tQIp............pL.pcuGs-....IVRluVPs.-uAcAlttI+pp.....ss.lPLVADIHFs.h+.hALts........s-hGlcplRINPGNI....................................................sp.--+lctllcsA+-pshPIRIGVNuGSL............-.+.clh.p.KY......................stsTs-........AllESA...hcpsc.lh-clsF..cphhlSlKuSDV...hhhlp..uY.RhL.A.p.p.hD......................................aP.L....HL.Gl.T.E.A.G.ssp......p.G.......sl.KSAlulGhLLt-GIGD.T.lRV.....S...Lo.......u.-.P....s.E....E.l.............................................................................................................................................................................................................................................................................................................................................................+....V...uhcILcol......sl.....Rs.p.u...l..........ph..lu.CPoCGRp.ph.D.l.hphspplcptLc...clh..........tshcVulhGCVVNGPGEAcpADlGls.uGssc.....uhlahcGchhcpl.s.psphl-pL.t.lct..th...........................................................................................................................................................	0	329	616	783
+2677	PF02155	GCR		Glucocorticoid receptor	Mian N, Bateman A	anon	IPR001409	Family	\N	25.00	25.00	29.60	25.50	18.70	18.30	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.21	0.70	-5.72	5	165	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	79	0	32	162	0	305.40	50	50.18	CHANGED	VhDFasshRGGs...olpsSsSssPTSluSQSsS+QQP.......lsuDhsNGLsNNssQPDLSKAVSLSMGLYMGEoEsKVMGNDluF..PQQsQsulSoGETDFuLLEESIAsLN+Sooss-sllGuss......Pp-htsLKTc.DsSsps+sclcuQsGSNGsStlKLslsDQ.....SThDILQDLELPssSP.GucoN.sPW..DhLhDEs...uLLSPLu.sDDoFLhEGN.hsEDsKPlsLsDoss..KlsDsucpsLLosuslslPQVKTEKE...DFIELCTPGVIKQENsGslYCQuulSGuslhGsKsSAISIHGVSTSGGQMYHYDhNTuTl.SQhQQDQKPIFNlhPPLPSuSEuWNRCQGSsD-shAolGslNhsuRosFSNGY.SSPuhRPD	.............................................................................shSss.s.husss..sssh.p........h.hDhspG.sss.s............................-LopA.lo.hohGlhht-s-s.KshspDhth...Q..Q...s..Q.....hul.os...G.......Epsh..p...L..LEESIAsLsp.....o..o...oss.-sshuuss......P.ch.....KTc...chS...-....ppp..h...csps.u.osGss.hcL.sssp...............sThD....I....LQDLEhsss.P....Gpcos..ssa...DhlhD-............sLL......SP...Lu.t-Dsh..Lh.-us..........sscDs.KP.llls.csps...............pl.pcsu............c...............h.L..s.............s.......s....s.sl.....shP....p.......VKsEK-...DFIcLCTPGVIKQEK..h...G.s.sYCQ......uuhsu..usl.u....s..+hS...uIS...lp.GVSTSGGQhYHYchNou.......Sh..uQ.Q..Q.DQKP.lFNlhPPlPssSEsW...NRsQGsG-ss...hs...shG..s..h.s........h.s...upos...FSsGa..SSPu.Rs-............................	0	1	3	11
+2678	PF04107	GCS2		Glutamate-cysteine ligase family 2(GCS2)	Kerrison ND, Finn RD	anon	COG2170	Family	Also known as gamma-glutamylcysteine synthetase and gamma-ECS (EC:6.3.2.2). This enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis. Members of this family are found in archaea, bacteria and plants. May and Leaver [1] discuss the possible evolutionary origins of glutamate-cysteine ligase enzymes in different organisms and suggest that it evolved independently in different eukaryotes, from an ancestral bacterial enzyme. They also state that Arabidopsis thaliana gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast and Escherichia coli homologues. In plants, there are separate cytosolic and chloroplast forms of the enzyme.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.67	0.70	-5.30	12	2189	2012-10-02 17:21:26	2003-04-07 12:59:11	8	10	1592	13	681	1830	1695	275.90	24	68.31	CHANGED	lGlE.Ehhls-.hsh.ht....pshh.ttshhshs...tsshhp...tstlEluss.PhsslpcshpphtpshptltphssphGlthhulGhpP.hphtph.lhsssRYpthhphhsp....s.upphhhtstplplslcsus-t......sthhphhhshhPlhhALuAsSPahpG+soGatSsRtplapphss...u.lPhshsc...acpahchhhcsshhtshp...............chahchRsss.h.s....hh-lthptssh.....lh.cthhch+hhsutst.chsshsshhhsshhcs..h.pstacAs+.hh	.......................................................................................GlE.Eh.lh.s....shths.............ps..hh......t...t.s..h...thp...............ss..p.h...hp-hstu.lElu.os..s...t....p....s..lp....pstsplsthhphltpsAs..ph.....s.....lt..l.husGscP....h..t.p....h....p....c...p...t..l...hs.p.t.....RY.......pt..h.h....ch.h................sh................................h..u...........p..............ph.h.......h...............h.......up..pV.......pVsl.ssu..............s-sh.................h.hhcshpthhPh...........hl.....ALu..AsSP.ah.pGp..s....oG.a...tS.....tR.p.la.p.......p.hss..................sGs..h.P.h..h.....h.....s......t...........t....ac....t......hhchhhp.....s.s.hh.shc..............................................ch.ah-h.R..sss..thu..........shE..lcsh.c......os........sh...c..thh.h...thhpu......h.s..h..h.h.l.s....t..h.s.h.h........h.t.....................a.......hh.stapus+.h.....................................................................................................................................................	0	201	465	597
+2679	PF01597	GCV_H		Glycine cleavage H-protein	Bateman A	anon	Pfam-B_988 (release 4.1)	Domain	This is a family of glycine cleavage H-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.40	0.71	-4.43	14	4486	2012-10-02 20:27:15	2003-04-07 12:59:11	14	10	3523	30	1292	3350	2660	118.10	40	88.84	CHANGED	LhYspcHE....Wl+scps.ssTVGITcaApcpLGDlVal-LPEsGsclpps-shuslESVKssS-lYuPloGpVlElNccLp-sPsllNccPY.tcGWlhKlKs...ss.c-hcp.LhsucpYtchlcc.	.........................................................................h+YocpHE..........Wl......+..........h....-.....u.....-................s.....sslGIT...............-aA..Q.-....tL.GD..lVFV-.L.......P..-......l..Gs......p.l.st.....G.-s.h..usl..E.S.V.K.usS..D...l.YuPl..o.GcVlpV...N.-s...L.p.-sP.......c.l.l.Np....-.P....Y....sp......GW..lhKl..ch.....s-.......s....p....l....c...s....Lhs.sptYpthh...t..........................................	0	431	806	1082
+2680	PF01571	GCV_T		Aminomethyltransferase folate-binding domain	Bashton M, Bateman A	anon	Pfam-B_933 (release 4.0)	Domain	This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase. 	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.15	0.70	-11.08	0.70	-4.96	131	7911	2012-10-01 23:12:28	2003-04-07 12:59:11	16	47	3499	47	2456	6628	15559	195.20	23	43.65	CHANGED	lhDlSp..huplplp......Gs-..At.....paLpplhssclstlt...sGpst.hshhLsp.pGtllsDhhlh+hscs.t............ahllssuustppshtalp......chhh.........plplpshosp...huhlultGP.....putpll...ppls....................sth.hhphtth.......h.....h........hlsRsuasGE..GaElhh.ss.............cp....stplactLht.s...thpssGhtAh-sLRlEtGhshhGp..........-h.s.pph..sPhEuuLt.ah	.....................................................hhDlSp.huhlplp...........G..s...-.....ut.....pa.L....p.tl...........hs.s.-..l...........s.p........ls..................sG.p...s...h...ashh..h.....st..p.....Gt...lhsDh..h..lhch...s-s................................ahl...ls.s...u...us..........t.............p..p...s.....h.s...alp...........................................phh.t...............cVplp....sh.ss.............huh.l.u..l..t....GP...........................put.t..hl.........tplh.........................................pt..h..h.h..tht.h.............h.s...h................................hlhp.s..u...........a.s.G.....E.....G....a..Elhh...st....................................pp......u.tlhptLht.....s..............................................l..p..s..s.Ghts..h..c.sL.R.lE....t...G...hshhup....................-h...s.tph........sPhpssht..........................................................................................................	0	718	1448	1998
+2681	PF04295	GD_AH_C		D-galactarate dehydratase / Altronate hydrolase, C terminus	Kerrison ND, Finn RD	anon	COG2721	Family	Family members include the C termini of D-galactarate dehydratase  (EC:4.2.1.42) which is thought to catalyse the reaction  D-galactarate = 5-keto-4-deoxy-D-glucarate + H2O, [1] and altronate  hydrolase (altronic acid hydratase, EC:4.2.1.7), which catalyses D-altronate = 2-keto-2-deoxygluconate + H2O [2]. As purified, both enzymes are catalytically inactive in the absence of  added Fe2+, Mn2+, and beta-mercaptoethanol.  Synergistic activation of altronate hydrolase activity is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre, but the function of  the single bound Fe2+ ion is unknown.  The hydratase has no Fe-S core [3].	19.40	19.40	19.40	20.40	18.90	19.30	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.23	0.70	-5.81	114	2289	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	1384	0	458	1521	2260	381.60	41	82.16	CHANGED	p.tTFpGY+RsDGp.VGsRNhlhIlsoVsCsssluctlActhptp................................................slD..........Gllsl.sHshGCu.hs...p-hphhp+sLtGhuppPNhuG.VLllGLGCEssphsplhps.....hsttt....ctlc........hhslQ-s..tG.tcslppGlphlcchltp.AsptcRpssshScLslGlpCGGSDuaSGlTANPslGhsuDhLlptGGTslLoEsPElhGAEclLspRAtsp-Vuc+llchlpha.cpYht.ptsssh.ssNPSPGNKtGGLoTl.EKSLGustKuGos.slssVlcYuE...lp..p.pGLshhso...........PGtDssusTu.sAuGsslllFTTGRGoshGsh.sPslKluoNoshhc+hp-.hDlssGsllsGptol-chGcclachllcVASGct.TpuEth..GppEhs.aph.....Gssh	..................p.hsFpGYRR.ss.Gp.VGsRNhlhIlsoVtCssslschlsphh.cc.................................................h...th...slDGV..s.slsH.aGCu.ht......ssth.hsh+sLtshuppPNhGu.VlVl..GL....G.CEp..Qsptlhcs......................hschss..............cpsp.............hhshQcp...G.pstl-sulphhcch.hpt.hs...pppRcssshSELhlGhpCGG..SDuhSGlTANPslGhsSDhLlpsGu.TslhoEssEhhGAEplLtsRAh...sccltc+Llphhsh.......acp.Yht.....t.t......p.p.sh.....ssNPSPGNKtGGLoTl.EKSLGsht.Ku.Gpo.sls-VLphG....-....+.p........p....pG..Lhhhso............PusDh.Vs.sTs.sAuGsplhl.FTTGRGTPa.Gsh..........VPs.........lK.........luTNopLsp+h...t-hhD.lsAG....slhpGt.pol-pl....upclhchIlclAsG+p.TpuEph.......tap-.h.ulapsuss.....................................	0	130	277	372
+2683	PF01150	GDA1_CD39	GDA1_CD39_NTPase; 	GDA1/CD39 (nucleoside phosphatase) family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	21.20	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.52	0.70	-5.99	9	1515	2012-10-02 23:34:14	2003-04-07 12:59:11	12	8	341	38	858	1436	26	351.80	24	78.66	CHANGED	.htpp-sh+YullhDAGSoGoRlaVY+a.sp..........c.shhtlsttlcc....hphlsPGLSoaupKs..................cpsuphLpPLL-hAcphIPppppsp..........TPVhltATAGhRLLtt-...tpptlLcsLpshlpshssa.spp..ptlpIIsGppEGhYuWIslNYLLG+hscc..............pppTsGslDlGGASsQIsFs.p..pt...stplcsst..hhpphchhspcY...slYspSaLsYGhspuhpphltpLlpssss..............hpsPCh..Ghppshshsslp................hthpususappCppplhcllp....st.Cs.p..pCtFNGVasPs....tppphtsSshaYhs.shhshsuph.....hs.pchscts+phCs..psWsplpsshspst.p.ls.....phChcssa.holLhsGFshshp..........cphpsspcIpsp-....huWsLGshl.hssshsh.....................pppLtss	.....................................................t.......pY.ulhhDAG.......So..GoRlalapa.t......................................................................p.h.....h........h..p......................ht.h.h..t..P.....G.......l.....S..s......asp.ps..........................pt.s.u.p.t.l.p.L.l.p.h.....Ahp...h.....l...P......t.p..h.h..tp..............TPl...hlh.AT.A.GhRl.Ls.p.......ptptll...pt......l.....p...p..........h.h...p.............t...sa..h..................ptspllsG.p.p.......E..Gh.auWlshNaLh.......G.phtp...............................................................tppThGh..lDhGGu...SsQ.....ls..F.sp...............................p..h..........tt.........................h......h.......p...h.phh..s....ppa.................plYspSaLsaGh....tAtpt....h..h..t..thhp.....t.t...t.........................................................................h.........p..PCh.....s.h.....p.....t...p.....h..ph.....t..t.............................................h..t.....u..t.u.....s..h..t..C..ht.h.....hhp.......................s.........................s........h....s....u..la............s.............pt..hh...h....p..aa..h...t.....h.....t....h..ht..........................phtphtttspphCt.......h.t.............h....t...................t................................................................hChphsahhslLh.p...G..aths.t...................................................lp.hhpplts..p.....hsWsLGh.h.l.hht............t................................................................................................................................	0	240	423	643
+2684	PF02347	GDC-P		Glycine cleavage system P-protein	Bashton M, Bateman A	anon	Pfam-B_840 (release 5.2)	Family	This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources.  The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC)  also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T [2].  The reaction catalysed by this protein is:-  Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.34	0.70	-5.79	13	6351	2012-10-02 18:26:03	2003-04-07 12:59:11	11	14	3103	20	1832	6081	5305	362.70	31	75.92	CHANGED	cRHIGsspp-ppcMLpslGhsoL--LhtpsVPssI+hpcshphsts............hoEpEhltcLpslAu..+Npl.a+SaIGMGYYsshlPsVIhRNlLENsuWYTpYTPYQsEISQGRLEuLLNaQTMlsDLTGLslANASLLDEGTAAAEAMthshphsKpK.tp+FlVspssHPQTlsVl+TRAcshslcllhsshp-hshos..........s-VsGVllQYPsT-GclpD...as-llcpAHpptshlssAsDLLALolL+PPGEhGADIsVGSuQRFGVPhGYGGPHAuFFAsppc.....htRpMPGRllGVo+DusGKpAhRLALQTREQHIRRDKATSNICTAQALLANhAAhYuVYHGspGL+cIAcRlHstTshLApuLcc..sshplpcshaFDTLplpsss.puspp.lLc+Ahtpt..lNLRhs-ss.slululDETsTccDl-sLlplF	.......................................................................................................................................................................................................................................................t........lPt.t.l..........t....p.....................h...s..ts......................................toEt-hlchl+pLus..............+.N...h..s.....p...u...h...I...shG..ps.h.p.h.sss..lpt.......h..l..p.Pta.....h..s..s..a...s..P......a.Q.P......E......h......u....Q..G...t.L.ch.lh..p.h.Q...p.h..............l.s-L.......T.Gh-....hs....s...s.S.L...s....p..u.s.....A...t..u.....E.......A....h.......h....l.......s.......h......R.....t.......t......+.......p......c.........p.s.....p.........h.....h..ls.ss...s.H...sps........h.s..........s.......h..........s...p.......A....p.h......h......G......h......c......V......l.....s.....s...s..h..p..p..p.s.s.hD....................................tss.l.u.ul.hlp.Y.P.u.T.p.G.h....h...E.....-.....lp.cl.sp.h.l.H.......p..t.G............u....h.l.h.l....u...............A.s....h.....A.l..s....h..Ls.s.P.....G...c.h..........G.......A...D.ls.ls...pps.F..u...lPhG.....h.GGPtsG.hus+sc........Ltthl....P.G..+.h.l.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	604	1157	1560
+2685	PF00996	GDI		GDP dissociation inhibitor	Bateman A	anon	Pfam-B_1220 (release 3.0)	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.44	0.70	-6.17	9	1094	2012-10-10 17:06:42	2003-04-07 12:59:11	13	17	362	23	674	1189	269	337.00	30	82.45	CHANGED	MDEE.....YDVIVLGTGLpECILSG.LLSVsGKKVLHlDRNcYYGGESASlo.LppLYp+F+st..........................tppP.pphG+uRDWNVDLlPKFLMANGpLV+lLI+TcVTRYLEFKsV-GSYVa+.........pGKIaKVPus-hEALsSsLMGlFEKRRh+pFl.aVssYcEsDspTaculD.p+toMp-lacKFsLspsT.DFlGHAlALapsDsYLppPAh.TlpRIpLYspSluRYGKS..PYLYPhYGLGELPQGFARLSAIYGGTYMLs+PlD-llatcs.GKslGV+S.ts-lA+sKpVlsDPSYhP...cKl+psG.+VlRsICIhsHPIPN...TssupSsQII.lPQsQlGRKSDIYlshlSasHNVssKGhYlAhlSTslETssPthElcPuLcLLGPlpcKFsplp-laEPhs-GscsplFlSpSYDAToHFETsspDVhsIacchsGpsLshsppptpp	........................................................................................................................paDlllhGTGL..Eslluu....h...hS.hp...G..pcVLHhDpss.a.YGu.p.....u..oh.s....lp....p...l...h.p...hh..p............................................................................................................t......t.h..s.p..s....+caslD.L..h..P.Khlhup...G.tLlphLlp.opV.s+Y.l-Fp.lts....a.lh.p...................................................ts...p..l......p.VP..s..s..c..-sht.o..h......h....u............hhEKRp.h.......h+Fh.a...l..................p....a............p.....t.......p.........p..s.........p.............p.......h..........p.....s........h.....p......t.........p......s....h....pp.h........h..p.p..a.......t...L.........t...t......sh........p.hh.h.a.ulAL..h....s...s.p...........h.p..t........s.......h................p......s...lp.c.hp.ha.....p.Slu+a......G..t.o.....P..alaPhY.G.h.G.ElPQuF.s.RhsA..la.G.GsYhLs...p...s...l...p...p...l..................h...........p..........p.....s....c.........h....h.u.......l...p.....s.......tt.......p...........h........h....p..s.....c.ll.....s......s.s..o....ah......................pp...s...p............h....s.....p.l..R....s.lhlh.p.p.sl...t..............st.p....s..t.....s...h....t...ll......hP.............t.....p..h......s..p...............p..t...................h.h.l..h.hu.sp.ss.spG.......hh.lhh.h.os........p...s.....t...p..........t.-.lt...s....h...t................................................................................................................................................t.......................................................................................................................................................................	0	223	348	528
+2686	PF02351	GDNF		GDNF/GAS1 domain	Bateman A	anon	Pfam-B_889 (release 5.2)	Domain	This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons [2].  GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity [3].	21.50	21.50	21.70	21.50	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.16	0.72	-11.45	0.72	-3.47	64	955	2009-09-11 15:54:25	2003-04-07 12:59:11	11	8	83	11	503	812	0	84.70	24	52.80	CHANGED	ClpAt.ctCpt-.pCpsthpt......ahppCts.........................tsstpCs...................scChpuhpsh.hsslhs................CpCpts.ppp.ppCtphtpphh.tssC	.............................CLcst.ctCpt-p..hC.p.p..thpt......ahppCts................................t.ssppCst.....................pcChpA...hpsh..h...ssshs....t...........CsCpts.........p.ptCtphhpphh..s.C...............................	0	47	105	259
+2687	PF02212	GED		Dynamin GTPase effector domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.88	0.72	-4.09	95	1604	2009-01-15 18:05:59	2003-04-07 12:59:11	13	34	368	21	867	1583	18	89.90	28	13.21	CHANGED	ppphpschIpph...lpSYasIVp+pltDplPKsIhah.........................llppsccplpppllppLhcpct...hspLLpEsstlsp+RcphpchlctLppApphlscl	............................phphchIcph...lpSYhp.I...l.p+sl.pD....t....l....P.K.s.Iha.h......................................................................hl...p..ps..K....c..p....l...p...s.c.LlspL..hp..psp.......hspLL...pEssphsp+...RcchtchlctLpcAhphlsp.............	0	252	456	678
+2688	PF04807	Gemini_AC4_5		Geminivirus AC4/5 conserved region	Mifsud W	anon	Pfam-B_3520 (release 7.6)	Family	\N	18.70	18.70	19.20	20.30	18.50	16.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.82	0.72	-7.28	0.72	-4.47	11	267	2009-09-10 17:27:41	2003-04-07 12:59:11	7	2	169	0	0	239	0	32.80	49	22.87	CHANGED	pIVLHpsustLlVcHlKaLoKlhhsu.htoTVos	..MpVLHuspTGLllKHlKahoKILhhh.pRoolTs.....	0	0	0	0
+2689	PF00799	Gemini_AL1	Geminivirus_AL1;	Geminivirus Rep catalytic domain	Bateman A	anon	Pfam-B_286 (release 2.1)	Domain	The AL1 proteins encodes the replication initiator protein (Rep) of geminiviruses, which is a replicon-specific initiator enzyme and is an essential component of the replisome [1]. For geminivirus Rep protein, this N-terminal region is crucial for origin recognition and DNA cleavage and nucleotidyl transfer [1].	21.10	21.10	21.20	21.20	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.43	0.71	-4.23	11	3067	2012-10-02 18:54:05	2003-04-07 12:59:11	15	7	1057	2	10	2756	11	106.30	58	35.36	CHANGED	FRlpuKNhFLTYP+ColstEcsLppLtsLppphshp.YItlsREhHpDGpPHLHsLlQhEu+hphossRaFDLspspp..s.FHPNIQuAKSoscV+sYIsKDG....sohEaGpFphcu	..................................FplpuKNaFLTYP.+C.S.Lo.K.E.E.ALsQLpsL.p..o....P...s..sKK...a.....I+...lCRELH.E......DG.p.PHLHVLI..QFE.G.Ka..pC........p...N.sR...FFDLsSPoR...Ssa.............FH..PNIQ................u.A.K...S.S.o....DVKsYl-KDG....Dhl-aGpFQlD.G.................................................	0	4	6	6
+2690	PF01440	Gemini_AL2		Geminivirus AL2 protein	Bateman A	anon	Prodom_1117 (release 99.1)	Family	Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL2 gene product transactivates expression of TGMV coat protein gene [1], and BR1 movement protein.	25.60	25.60	25.80	27.50	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.86	0.71	-4.07	116	1883	2009-09-13 07:36:57	2003-04-07 12:59:11	11	4	905	0	0	1605	0	131.50	56	96.44	CHANGED	Mps..SSPSps+ST.ssIKspHRhAK+..+.slRRRRlDLsCGCShYlpIsCps..HGFTHRG.sHHCoSucEWRl....YL.GssKSPlFQDs.psptpslppppph.....ppssslQPQPpESsGsoQshspLPsLDslTsSDWu.Lps	.............MpsSSPSpsHsTpVPIK.VQHR.hAK+.....+slRRRRVDLsCGCSYYl..pI.sCp........N..HGFTHRG.THHCoS...u+EWRl....YL.GssKSPlFQDp.psppps.lppc.pH....ppsssslQsQPpESsGs....oQhFS.pLPsLDDlT...sSDWuFLK........................	0	0	0	0
+2691	PF01407	Gemini_AL3		Geminivirus AL3 protein	Bateman A	anon	Pfam-B_1874 (release 3.0)	Family	Geminiviruses are small, ssDNA-containing plant viruses. Geminiviruses contain three ORFs (designated AL1, AL2, and AL3) that overlap and are specified by multiple polycistronic mRNAs. The AL3 protein comprises approximately 0.05% of the cellular proteins and is present in the soluble and organelle fractions [1]. AL3 may form oligomers [2]. Immunoprecipitation of AL3 in a baculovirus expression system extracts expressing both AL1 Pfam:PF00799 and AL3 showed that the two proteins also complex with each other [2]. The AL3 protein is involved in viral replication.	22.70	22.70	32.80	26.60	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.54	0.71	-4.65	97	1723	2009-09-13 21:06:47	2003-04-07 12:59:11	12	3	909	0	0	1578	0	119.30	59	89.59	CHANGED	DSRTGE.IT...AsQApNGVaIW-ls......NPLYFKIhpHppcPhhp....ppcIlplQIpFNHNLRKALGlHKCFLsFpIWTshps...tTGp.FL+VF+.......pQVh+YLcsLGVISINNVIRAVsaVLassl.pp...sl	..................................DSRTGEhIT...AsQAc.N..GVaIWEls......NPLYFKIhpHspRP.Fhp....spDIIolQIpFNHNLRKALGl....HKCFL.sF+IWTTLpP...pTGp.FLRVF+.......tQVlKYLssLGVISINNVIRAVcHVLasVlppT.h....................................................	0	0	0	0
+2692	PF00845	Gemini_BL1		Geminivirus BL1 movement protein	Bateman A	anon	Pfam-B_1535 (release 2.1)	Family	Geminiviruses encode two movement proteins that are essential for systemic infection of their host but dispensable for replication and encapsidation.	20.20	20.20	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.79	0.70	-5.03	17	508	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	260	0	0	471	0	250.50	54	95.03	CHANGED	sYIcScRsEYpLopDhT-IsLQFPSohpQhsuRLptpCMKIDHsVIEYRpQVPlNAoGoVIVEIHDpRhoDs-ShQAuaTFPItCNlDLHYFSSSFFSlKDPhPW+lhYRVsDoNVhpusHFA+hKGKLKLSoAKHSsDI.F+uPTlcILSKpaopcclDFapVshuKhp..R+Llpssshs...phuh+tP.lpltPGEoWAo+S.sIG............................st..spppspsspaPYRpLp+LssutLDPG-SsS.s......us.shopsplp-llcsTVpcClposspsspsKsL	....sYI-ScRsEYpLopDhoEIhLQFPSshpQhou+LptpCMKIDHsVIEYRpQVPlNAsGoVlVEIHDpRho-s-ohQAsaTFPItCNlDLHYFSSSFFSlKDs.PW+lhYRVpDoNVhptsHFA+hKGKLKLSoAKHS.sDI.F+sPTlcILSKpaTtcslDF.pVshsc.p..R+hlpsssht...phuh+tP.IpltPGEoWAo+S.pIG.............................s...sp.ps.pss.aPY+pLp+LssssLDPG-SsS.s......ts.ohShtplp-llcsTlpcCl.ss.pss.sKt....................	0	0	0	0
+2694	PF01492	Gemini_C4		Geminivirus C4 protein	Bashton M, Bateman A	anon	Pfam-B_453 (release 4.0)	Family	This family consists of the N terminal region of geminivirus C4 or AC4 proteins.  In Tomato yellow leaf curl geminivirus (TYLCV) the C4 protein is necessary for efficient spreading of the virus in tomato plants [1].	29.10	29.10	29.70	29.70	28.80	29.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.71	0.72	-4.25	79	1778	2009-09-12 04:38:53	2003-04-07 12:59:11	12	4	816	0	0	1410	0	82.00	49	82.94	CHANGED	MGsLIShssssSKsNosA+IsDSSThaPQsGQHISIpTFRELsss.hSsPT.p+TETshsG-sSRSh-DhLEEVuph.TTphPRp	..........MGsLIshsSSsSKuNosA+hsD.SSThaPQsGQHISIpTFRELN.ss.hSpPT.pRTETs.sG-s.RSh-DhhEtssp..hThhP+p..............	0	0	0	0
+2695	PF00844	Gemini_coat		Geminivirus coat protein/nuclear export factor BR1 family	Bateman A	anon	Pfam-B_1430 (release 2.1)	Family	It has been shown that the 104 N-terminal amino acids of the maize streak virus coat protein bind DNA non- specifically [1]. This family also includes various geminivirus movement proteins that are nuclear export factors or shuttles. One member BR1 facilitates the export of both ds and ss DNA form the nucleus [3].	23.50	23.50	23.80	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.35	0.70	-5.14	41	3840	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	1300	0	0	3087	0	202.70	48	94.35	CHANGED	RRphshss.....st...hpcssstp+stsp..htRpsphh+hh+ss........sh+lpshp......tschsls....ssuhsphlossspGps..spRsssthplKpltlpGplhh-cshpphsts.......sshhhaLVhDR+Pptssss....sFsplFsh...hpspsuohslpssl+-RFhVh+paptslssst........ss.h..hssppph.s+RFhphlsh+sha.ppsssGpYsNlpcNALllYhshhpssssshuoh.........hhlhFcsshss	.............................................................................Rthshsp...thsss...shstss.+tp.s....W.sp....R....P.M.....hRKP+.hYRhaRSPDVP+.......GCEGPC.K.VQSaE.........p+pDlt.HhGhl..hClSDVTRGsG..lTHRlG.KRF.ClKSl.YlhG...K.l.WMD-NIKppNHT........NsVhFaLVRD.RRPh.s.sP.....cFuplFNM...aDNEPSTA....TVKNshRDRaQVh++apusVsGGt.................h...us.+EQ.A..l.l+.+..Fh+.lNsaVsY..NpQEsu.KY.-NHoENAL.h.LYhshhp.ss.ssshssh...........h.Fh.sh.............................................	0	0	0	0
+2696	PF01708	Gemini_mov		Geminivirus putative movement protein 	Bashton M, Bateman A	anon	Pfam-B_1771 (release 4.1)	Family	This family consists of putative movement proteins from Maize streak and wheat dwarf virus.	25.00	25.00	33.50	33.40	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.00	0.72	-4.44	10	288	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	88	0	0	221	0	81.80	47	87.79	CHANGED	MDth.hss.h.spss....Pp......VPssAPuuuslPWSRVGElsIhohVAVlslYLLYsWVL+DLILVlKA++GRoTEElsFGssst+s....sussss	...........................pss.Y.pPR......VPo.uAPs.SuslsWS+VGEVuIhsFVAllshYLlYlWVL+DLILVLKA+pGRoTEElhFGspssctsss..h.........	0	0	0	0
+2697	PF01524	Gemini_V1		Geminivirus V1 protein	Bateman A	anon	Pfam-B_893 (release 4.0)	Family	Disruption of the V1 gene in Tomato yellow leaf curl virus (TYLCV) stopped its ability to systemically infect tomato plants, suggesting that the V1 gene product is required for successful infection of the host [1].	21.20	21.20	22.30	23.80	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.48	0.72	-4.00	45	1677	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	796	0	0	1216	0	75.00	69	68.72	CHANGED	MWDPLlN-FPE...TVHG.FRCML..AlKYLQt.lcpTYuPDTlGa-LlRDLIsVlRu+NYsEAopRYscFpuRl..puTspuELRQ	..............MWD..PLLNEFPE...oVHG.FRCML..AlKYLQh.lEpTYsPD.TLGaDLIRD.LIsVlRARsYVEAo..pRYsHFauRl..EGost..uELRQ............................	0	0	0	0
+2698	PF02053	Gene66		Gene 66 (IR5) protein	Mian N, Bateman A	anon	IPR000714	Family	\N	20.10	20.10	21.30	20.50	18.80	20.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.50	0.70	-4.91	6	66	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	29	0	0	57	0	175.70	37	67.47	CHANGED	Mpsha..........sDtphcosuthh..sutculYPhh.ssousHssSLPRSV+shApsVhssut-AhsAhRuGtPPPAclW.cVYchasssFpcaptS.....husFHsAsPlR+hVGchLhshssAP.ETHuELusRLLaCuYWCCLGHAusCShsphYE..csChRFF-pshGhGEsP.s-uEpYWpsLhshsuscsphh.+asAtsAahptRsR+hsls................u.sh	.........................ttthhcpsssp.........................sssusLYPlp.spshAHhshLPtshRshhcslspsSp.stssl+s..s.PPssthh.hlhcphphsaspahRu.....ppphpsl.PhRpAshsalss....husts.pTH...cchc-hLhh....CAaWCCLuHAu..........T..........CShAtLYs...sp..Ch+LFss.FGCGs..................................................ss.ss..................	0	0	0	0
+2699	PF03323	GerA		Bacillus/Clostridium GerA spore germination protein	Mifsud W	anon	Pfam-B_3821 (release 6.5)	Family	\N	20.70	20.70	21.00	20.80	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	470	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.23	0.70	-6.36	152	1955	2012-10-02 18:57:54	2003-04-07 12:59:11	8	8	418	0	415	1730	13	442.60	33	90.93	CHANGED	Nlphlc.phhs..pssDlhhRch....................tttshc.ssllalcGlsDpphlp..ppllcsL.....................ttttptphhpplh..pph...lshsplpphp.shccllpplLsGpsllhl.-Ghs..pulllsspsh...pRulpEPpsEpllRGs+-GFsEslpsNhuLlRRRl+sspLphcphplGcco+TclslhYIcsIss.cllccl+pRlppIclDsl.hssuhlEphIpDps.hosFPplt.TERPDtsuupLhEG+lsIllDGoPhslIsPsohhphhQssEDYap+ahhuoh.lRllRhhuhhlolhLPulYlAlhoaH.-llPspLhhslsusRpslPFPsllEsLlhElshElLREAGlRLPpslGpslGIVGullIGpAAVpAGllSshhlIlVAloAluSFshPsYphuhulRllRFhhllhuuhhGlhGlhluhhhlll+LssL+SF.GhPYLsPhsPh..phps.h+DsllRhPhhhh....p.pR.......Pphlp	......................................................................phlp.phht....pssDlhh+ph......................htshp.hslhalculsDpp.hlp..p.llpsLh........................................p..t..p......t.hp..p.hh..pph.ls.h.s...plpthp.shpclhptlLpGpsllhl.-.s.s.............p.s...h...lls.spsh...p..RulpEPpsEtslRGP+-GFsEslssNhuLlRR+l+sspLphcphp.lGcp.op.TclslhYlcslss.cll...pclcpRlp.pIchDs.l..hssuh.l.E.ph.I.p..Dps..hosFPphh.TERPDtssssLl-G+luIllDGoPhsLlsPsoahphhQosEDYhpphhh.uo.a.lRllRhh.uhhlulhhPulYlAlhsaH.pl..lPspLhhslhsuRpslPFPsllEs.LhhElshElLREAGlRLPpslG.pslGIVGGllIGpAAVpAGlsSshhlIlVAloAluSFshPs.aphuhuhRllRFshhlhAuhhGlh.....Glh.....lGhhhlhhHLspL+Sh.G.s.PYhtPhh...Ph...p...h...p...s...h+.Dhhl.RhPhhhhp.pRPt...p............................................	0	209	341	357
+2700	PF00196	GerE		Bacterial regulatory proteins, luxR family	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.43	0.72	-4.65	30	38873	2012-10-04 14:01:12	2003-04-07 12:59:11	14	273	4244	74	9895	30161	2583	57.10	31	20.74	CHANGED	hssLopREtpVLchlspGhoNcpIAppLslSp+TVpsHhsslhpKLslpucsplsphA	.......................h...Lot.RE.t..c..l..L.p.h...l..u.......p........G...h....o....s.p.c......IAppL.....t.......l......S.t.p.T.....VcsH.h...p.......s....l..h.p..K...L...s...lps.+sphshh.........................	0	3079	6345	8321
+2701	PF01353	GFP		Green fluorescent protein	Bateman A	anon	SCOP	Domain	\N	25.00	25.00	36.30	36.10	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.25	0.70	-4.97	27	306	2012-10-01 21:32:51	2003-04-07 12:59:11	17	7	114	621	18	1347	1	212.80	38	91.18	CHANGED	hssIK-pM+hKlpMEGsVNGHtFplpGcGcGpPacGsQ..shplpVscGuPLPFAaDILosuFpYGNRsFsKYPccI..PDYFKQSFPE...GaoWERshsaEDGGlsssosDIol...cG-.....sFhacl+FcGlNFPssGPVMQKKTh.tWEP.STEthYs..pDGlLpGclshALh.LcGGuHYpCch+ToYKuKKs.lph..PsaHFlDHRlEhhpccc.DhspVc.aEpAlA+hs	...............phlpttMph+lcM-GsVNGHcFslpGcGcGpPaEGpQ..shcLpV..s..c..GGPLPFuaDILossFpYGs+sFs+YPccl..sD.YFK.pu.h..P-...GYoaERohpF.........E.........DGGlsssosc..loh...cGs........shh.acl+hpGsNFPssGPVMpKK.Th..sW-P.S.s.Ep.h.hs..p-ssLpG.csshsLh.Lc.G...G.u+...apscacosY.....+....s..c....Ks...........l..ph.....P.shHalc+clphtp.psp..chpphp.hEhu.Ap.......................................	0	17	17	17
+2702	PF05165	GGDN		GGDN family	Bateman A	anon	COG2429	Family	I have named this protein family of unknown function GGDN after the most conserved motif. The proteins are 200-270 amino acids in length.	20.60	20.60	20.60	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.25	0.70	-5.33	4	106	2012-10-01 23:51:22	2003-04-07 12:59:11	7	2	91	4	64	115	25	210.80	32	93.13	CHANGED	M...shlQIDsYGPWTspPsPRREsDLQsLQucLYADlpc.huu+pGhVFhsRFDNMlulosGhsltsHcRlQ-uItNRYPlTVSMulusAcTPhDA.ctAspALpctGuAQsEpRpEsLsh.s.....ss-GYVpIAHIDlNslTtThTDhVushcThhpVpclhttLhchL..KhsAlh.FlGGDNhhAsssthp.t.lLclhsclc-phsl.....-LKAGIGhusTAccAusLAchALEcIR..Gths.sslsshcp	..................................h.sllplssYt.WT.o.sscREhtlQtlQucLatclpp.huthsuhsa.hRaDshlslsNGls.pphttl.pslppph.PlslshsluhucTPh-A.htAsttlpp.t.st.pt...p....................ss..ltluHhDlsshT.phTchhssa-oahplpphhhpLhchh.hp.hsulsh.....alGGDNhhs..h.st...hsppsh.phlpclpcphtl.............tl+sGlGhGpsAcs...AhhhAspuL.-tlR..tth..........t..................................	1	16	34	51
+2703	PF01134	GIDA		Glucose inhibited division protein A	Finn RD, Bateman A	anon	Prosite & Pfam-B_4007 (Release 8.0)	Family	\N	20.00	19.10	20.00	19.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	392	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.29	0.70	-5.61	122	6402	2012-10-10 17:06:42	2003-04-07 12:59:11	17	49	4313	22	1570	23497	12080	363.60	41	65.94	CHANGED	DVlVlGuGHAGsEAAhsuA+hGscshLl..............Thph-pluphsCNPolGG......AKGhLs+ElDALG.GhhucssDpsslph+hLNtp+GPAVtAhRsQsD+phYppthpctlcs...psNLplhpspVsclhspp................tth.G.lhht.s..h.sc........sVllTTGT.........aLtu.lhhG..th.sG...sp.hso.sLupsLc.c.hGhchtRhKTGTPPRlctcSIDasth.hpsu-.p.s.s....FSahsssh.......p...pcQ............hs.CalstTspps......HplI+cslc.pos.hasGp..IcuhGPRYCPSIEc...Kll+Fs...............-+spHplaLEPEuhsssp.hYhsGhSToLPhclQhchl+o.IPGLEsAclhR......GYulEYDalsPtpLh.s.oLEoKplpsLFhAGQINGT.oG..YEEAAA..QGLlAGlNAuh.phpscp	...............................................................................................................DVlVlG.u.GHAG.sEA.A.h..............Au...A..R.h...........G...h..p...slLl...........................................................Thp..h..-.....p.l....u....t...h.....s.....C.....N..P...u...l.G.G...............................u.K.G......h....L....l......+.....E......l........D........A.......L.....G........G.......h........h........u.....c......s....s........D.....p....s....t..l......Q....h.......+..........h......L..............N......t.....t.........K......G..........P.......A....V.......p........A....h.....R......u.........Q..s...D...R.......t.......h........Y.........p.....p........t....h.........p.....p.....t...l...c...s.................p..s..N..L...p......l....h...p..p........t...l...s.....-...l.h....s.pt......................................................tth..h.G.....s...h.....h.....t...........s.................h..t...u.p............sVllTTGT.................................................h.LtG..lhlG........p.....h....u.G..................t......p............s.S..h....s...........L.uc..pLc..c...hG.h...c.h......h.RhK.TGTPPRlcsco.IDas...hht.QsuD...s.s...............FSah.s..s.s.h.........p.....pQ................................hs...Ca.lohT.spps..................Hpl....lcsshc.....cus......h...asGh.........I-.u.h.G...PRYCPSIEc........Kll+Fs...................-+sp..HplFLEPE....Gh....s....ss..............p....hYhsGhS....T.S.LP..h.........clQ..hp...ll+o.I..................G...L..E.N.....A.......c...hhRs.............................GYAlEYDa.hs.....P.p.p.Lh.........s...TLE.......o.......K.......t...l..ps......LFhAG...Q...l....N...G....T.oG......Y......E......E......AAA....QGLlAGlNAAhthtsc.................................................................................................................................................................................................................................................................................................................	0	550	1026	1334
+2704	PF02527	GidB		rRNA small subunit methyltransferase G	Bashton M, Bateman A	anon	Pfam-B_1265 (release 5.4)	Family	This is a family of bacterial glucose inhibited division proteins these are probably involved in the regulation of cell devision [1]. GidB has been shown to be a methyltransferase G specific to the rRNA small subunit [2, 3]. Previously identified as a glucose-inhibited division protein B that appears to be present and in a single copy in all complete eubacterial genomes so far sequenced. GidB specifically methylates the N7 position of a guanosine in 16S rRNA [4].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.85	0.71	-5.15	17	4375	2012-10-10 17:06:42	2003-04-07 12:59:11	10	8	4276	14	957	4510	3558	182.20	33	82.38	CHANGED	phpphptYhphLhchNpphNLouhp..chpclhp+HllDSlslhphlcptc...t...lhDlGSGAGhPGlPLulhhPph+....lsLl-uhtK+ssFLcpltpcLsLsplpllpsRsEc.......ttpaDslsuRAluslsclsphshp.Ll+ssGhhlthKGtpst-Eltphcpthphpth.hhplsth.tt....pcplh	.............................................................pph.tYhclL...hcW...N.cth..N...L....Tulp..-.p.-..h...hh+H...lhD..Sl.s..l..h.........h...l....p....tpp......................p....llDlGoGuG.h..PG.I.PL.u..I....h....h....P.c....h.c...........hT.LlD..S..l....s......KR..l..p..F...L.p...p..ltp.c....L.....s...L..p...s....l..p...s...l.p...u...R.s....Ep......................ht..c.tpaD.h....V.....s....u....R.....A....l......A.....s......L........s..s....l...s...p.h.....s....h......s...L...l......c..............s.......G...p........h......l........A....h.....K..G...t..p..s..p..-.E..lt...p.h.pp.....s....h.p..h..h..th.....t..............................................................................................................	0	336	646	821
+2705	PF03227	GILT		Gamma interferon inducible lysosomal thiol reductase (GILT)	Mifsud W	anon	Pfam-B_1477 (release 6.5)	Family	This family includes the two characterised human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: Swiss:P13284 [1] and Swiss:Q9UL08 [2]. It also contains several other eukaryotic putative proteins with similarity to GILT [3]. The aligned region contains three conserved cysteine residues. In addition, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulphide bond reduction.	22.00	22.00	23.70	22.60	21.20	19.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.24	0.72	-10.81	0.72	-4.20	15	522	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	214	0	342	525	3	107.30	27	45.18	CHANGED	lplslaYESLCPssppFlpppLh.hh..hptshtshh-LcLlPFG.pAcsscsto.....spCQHGspECcLNtLpACsIcshsspph..........hshlsClpps.pshppuh......Cspchthpp	................................lplslaYESLCPssp..pFlhppLhPhh.....p..p..ltsh..lsl..pLlP...aG..pA..p...hp.s.sss................hpCQHGspEChhNhlpsCslph.h.......p....p.h................hthlhCh.pt...t...p........t.t..........Chp.....h............................................................	0	138	199	293
+2706	PF03359	GKAP		Guanylate-kinase-associated protein (GKAP) protein	Mifsud W	anon	Pfam-B_1892 (release 6.6)	Family	\N	19.20	19.20	20.40	20.00	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.39	0.70	-4.83	20	511	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	91	0	233	441	0	312.50	34	40.76	CHANGED	-s+tt....p.h..pIuhp...........h.p.pths.sp.tsc..t.hpSlGlQVc-chp.ptchp.................tosusousspsD.chps..t.s....ssspspsh..s..sshp+p.pp..........ss...pssthth.p+sVs.................pputhsh.............sstsscspsss.psuthsPsps....................................................t...sp+DGpaFl+LLpuEs-RLcuaCpphE+-.....tc-s-LsE.Ell..........GhIRoAVG................pApLLhoQKFpQFctLC-p........................................sh..........s..Psup.csTspDLsGFWDMLpLsIEDVshKF--LppLKsNsWp................ccssPshsKKPsKs................................+sshs+s+uh-uu........ttpRtcARcRLhAAKRAAphRQsp.......socpu-SlEIalPEAQTRL	........................................................................................................................................................................................................................tt............................................tt.....t.........hpS..lGl..Qsp..cp.h.p..............p.p.................................................s.ps.....h.osthp.s.-.php.t....t.........t.ppps.h..t.......tshtpp.p.....................st..................pslp...................................................................ps.hsh.....................................s..ps.s..s..s..h..psu.h.s.P..s.s..s..hps..p...................................................................................tssphuss...pRD.Gpa....F...l..KLL.puEs.-.RhEuWCppME+-........tcEss.L....sE...-l.L............G+IR.oA.VG................sAQLLMoQK...F.pQFptLCpp........................................sh...............s.....Ps.ut..P..cPTsQDLAGFWD.h.LQLsIEDlshKFc-LppLKsN.sWp.hp...................pp-c.....c.ssPsh.s...KK..ss.+s....................................................psshs....+p+u.-ss..........p.R.pcA...RcR...L.hAAK+.A.sphRpss.......tpEpu-..ohphhhsp..............................................................................	2	56	73	140
+2707	PF03275	GLF		UDP-galactopyranose mutase	Mifsud W	anon	Pfam-B_4203 (release 6.5)	Family	\N	25.40	25.40	25.50	25.40	25.30	24.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.56	0.71	-4.81	96	1461	2012-10-10 17:06:42	2003-04-07 12:59:11	8	6	1183	57	272	1189	350	188.00	47	53.74	CHANGED	thh+uYTcKQWGpcP.p-Lsu...sllpRlPVRhsaDspYF.sDpYQGlP..hsGYTphhEp..MLt.pts.....IcVpLss..Dahchpc................thttcllaTGsIDpaF-Yp...hGcLtYRSLcFE...........pcsh.spssaQGsuVlNYs-.p-hPaTRIhEaKHFps..........ts+Tlls+EYsp.h.....pcu-.....PYYPlssscsppLap+YpcLAcppp...sVhFsGRLusY+Y	............................thlKuYTtKQWGpss.p-LPu..............lIp..........R.L.PVRh..sa..........DNpYF.sDpYQGlP..hsGYTthlEp........M.....L.t...tps........I-VcLss..Dahp.+c.....................th.s.h...s+llaTG.lDpa...........F.-.Yp...hGcLtYRoLcFE.............pEhl...c........tsa.QGsAV.l...NYs-......t-sPYTRIhEaKHFp.t........................p.psKTlI.s...+EYst.h....ccG.D....EPYYPlNspcs..ptLappYpphAp.p.ps..........p.VlFsGRLGpY+Y...................	0	85	177	232
+2708	PF02812	ELFV_dehydrog_N	E_L_F_V_dh; GLFV_dehydrog_N; 	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	25.30	25.30	25.40	25.50	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.44	0.71	-4.57	262	6065	2009-01-15 18:05:59	2003-04-07 12:59:11	13	15	3955	213	1526	4625	1317	125.30	45	30.51	CHANGED	sc+......llhsph.h........ct.uphpshpuaRs.HssshG.PsKGGlRa.aP.t..............................ls.s....-lhtLuhhMTa..KsAlssLPhGGuKGul...hhD.......P+..ths.......ppE.hcclsRuasptltp...lusspslsAsDlGTssp-Mualh..cpappls	......................PcRhl.hclsh......h.Dp.Gplps.cGaRlQassAl...G....Ph....KG....G.lRFHP.s..............................Vshs.........lKhL....uht.oa..KNul......s........s......LP.hGGGKGG........chD..............P+..shS.......csE..l.RhspuahpELtc...alGs.spDVPAsDlGsuu+-huahh.spYc+l.p......................................................	0	538	1003	1309
+2709	PF00120	Gln-synt_C	gln-synt; 	Glutamine synthetase, catalytic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.60	22.60	22.60	22.70	22.30	22.50	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.73	0.70	-5.24	95	12610	2012-10-02 17:21:26	2003-04-07 12:59:11	19	19	7069	255	2691	9179	7704	221.90	30	57.41	CHANGED	stsPRs.lh++shpthpp.tGhs..shhGsE.EFaLhct....sc....ssts....sthss..........................hpsGhaslss..h-.pspclhp-hhpsh.tphGl.plEstH+EVusu.QhElshc.hssslcsADplhhhKhll+plAccaGhtATFMPKPhhsss..GSGMHsHhSlht...ttG.pshFhssts....sLSchuhpaluGll+HstulsAhssP......ssNSY+RLsP........uhpAPshluauspNRoAslRlPts......tsspupRlEhRhPDs........suNPYLuhAAlltAG	.................................................................................................t..ssRt..hpc.h..t...h..t.t........uhs.................shhG......E..Eaalhcp........sc...........s............th..............................................................t...hsu..h..ashss...hs...hpsh.hp-hhthh...t.h..Gl...s..l-.shppEV...............u...............s...............u....QaElsht.h.......s.......sslpsADph.............hhh+hll+plAc......p......a...........G.htsoFhsK..Phhsts.......G..oGh.Hsph..Slh.........t.................s....shh...........................st............t................t.....hs.p...th..hl.u....G.h.h.p.ph.......t......h.......shhss.........sssua+RLss..........th..A.s..s..hsau.........h........p..N.R...ss.........lRlPhs..........................t..ttclE....R.s.ss....................sssPYlshushh........................................................................	0	856	1657	2250
+2710	PF03951	Gln-synt_N	gln-synt_N; 	Glutamine synthetase, beta-Grasp domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-10.05	0.72	-4.40	188	7416	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	5499	249	1602	5187	2852	76.40	36	19.43	CHANGED	slcalchpFsDhhGthp.......plshs.......h..spl.........ccs.........hc.pGh.sFDGSSltGatslpcSDMhLhPD...sT..hhl-P..apt..t.....s.hhlhC-lhss	........................................................lphlchhFsDhhGh.p...........plphs...........pph..............pph.....................................hp...ps...h.hFDG.SSl..tG.a......s.t.l......p.cS...DMl.LhPD...po..hh.lDP...apt..t.......s..hhlhC-lhpP..................................	0	504	986	1339
+2711	PF03710	GlnE		Glutamate-ammonia ligase adenylyltransferase	Yeats C	anon	Yeats C	Domain	Conserved repeated domain found in GlnE proteins. These proteins  adenylate and deadenylate glutamine synthases: ATP + {L-Glutamate:ammonia ligase (ADP-forming)} = Diphosphate + Adenylyl-{L-Glutamate:Ammonia ligase  (ADP-forming)}. The family is related to the  Pfam:PF01909 domain.	20.50	20.50	20.50	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.51	0.70	-5.12	22	4102	2012-10-02 22:47:23	2003-04-07 12:59:11	10	13	2001	3	970	3413	962	243.30	33	50.29	CHANGED	ltpLhplhutSshlucplt+p....PhlL.cpLhs...hspspshpthtspLpphLhpsss-.....E............................phhcsLRpF+ppphhRIAhsDlhuhhs............lpclsppLotLA-AlltAulphhhppsssch.shP.t.t.sps..shhllGhGKLGGhELsauSDlDLlFhassssts.....sut+sl-stpaasRluQ+llphLst.TssGhlYclDhRLRPpGsuG.LshohsAapcYapppupsWE+.Ahl+ARsls.Gstplptpa.ph	.............................................................................................h..pLhplhutSshlsc.lt.p..p.........Pt..h.l..sp..Lhs...................p.s.....t..h..p..t...h.....t....s..p...L.p...p.h...Lh.....p...sssc..........p...............................................................phhcsLRph+ppphlR...IAhs.D.l....su..h..h.s......................................................................lt...plsppL..otLA-uhlsuul.ph..s..htph..st......c........a...G.......P...................t............p.....t........p......s......p...sh...................sllGMGKLGGtELsauSDlDLIFlacpssss..........................sutc.t.l..ss.t...paa...sR...lup+l....hpl....Ls.p...........T.......s.....s.Gh....l.acVDhRLRPpGsuGsLVhShsAhpcYh....p....p....p......u................h..sW..E+.Ahl+ARslu.G-..plttph..t..................................	0	261	591	797
+2712	PF03616	Glt_symporter		Sodium/glutamate symporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.20	21.20	21.20	21.50	20.70	21.10	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.18	0.70	-5.96	8	1846	2012-10-02 17:06:44	2003-04-07 12:59:11	9	4	1484	0	231	1070	118	354.70	42	89.10	CHANGED	lpLsshpTLllAsLlLLLGpall++lsFLp+asIPEPVlGGllVAlslhll+phtshclsFDtS.LQsshMLsFFoTIGLuAshspLhKGGKsLllaLhssssllllQNsVGluhAulLGlcPLlGLlAGSIoLoGGHGTuAAWussFt-p.aGlsuAsElAhACATFGLVhGGlIGGPVA+aLlp+pp...pspspsDsp-p.lspuaccsptp+pIsupsllETlsllslClslGpalusLlps...puLpLPoFVhsLFlGVIlRNhLohhhhap...V.-csVslLGsVuLSLFLAhALMSL+LWELtsLAlPlLlILsVQslsMlLaulFVTFRhMGKDYDAAVlsAGHCGFGLGATPTAlANMpuVTc+FGP	...................................................................plsshtTLshAs.llLLLG+hlspplshL++asIPpPVsGG.Ll.........s.........A.l....h..........l.......hl.....L............c......p........h....hs....h..................p.................l.....p....F....D....h..s............L...p..s.....s.......hML.sF.Fs..T...I.....G..L.........s..A.............s.h....s...p..L.....+.........t....G..G......+...sl...h.........l....F......l..h....ls.s.s.l..l.l.h.Q.N....s.l..G.....l......u.....h.....A..p.....l.......L......G..l.....c..P.L....h....G...L.....l..A..G.....S...I...oL..oG...GHGTuAAau.p.hat.-t..aG.h.....ssAh.pl..AhAsATFGL.VhGGLIG....G...P.V.A......+a.....Llc+tp......................hps..s..t.....t.......s.......-.........s.....p...........p.........................s...........p..........s...........a.......c..........p....s......p...t........s.....+....h........l.....T...u........s........h.........lc.........sl....s....l.........lslC....ls..lG.......p.......h.......l.u....p...h..l...ss.............ssh..........p....l....P..........s..........F....Vs..s..L..Fl.....GVIl....pNhl.s..h.h.t.h..hc..........l.............p..+.s........l..s..l.lGsVSLS.........LF.L..AMALMoLKLWcL.s.s..L..Al.Phll.IL.sVQ.slhMsL...a.Ah..F.V.T.a.RhM.....GKs..Y..DAAVluuGHCGFGLGATPTAlANMpulTc+aGs...................................................	0	69	132	190
+2713	PF01744	GLTT		GLTT repeat (6 copies)	Bateman A	anon	Pfam-B_681 (release 4.2)	Repeat	This short repeat of unknown function is found in multiple copies in several C. elegans proteins. The repeat is five residues long and consists of XGLTT where X can be any amino acid.	21.00	21.00	21.10	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.16	0.72	-4.49	35	266	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	125	0	137	344	218	28.60	43	14.72	CHANGED	GLsThGLsThGLsThGLsThGLsohGLsT	........GLss.GLso.GLso.GLso.GLso.GLs.............	0	84	101	125
+2714	PF02686	Glu-tRNAGln		Glu-tRNAGln amidotransferase C subunit	Bashton M, Bateman A	anon	COG0721	Family	This is a family of Glu-tRNAGln amidotransferase C subunits. The Glu-tRNA Gln amidotransferase enzyme itself is an important translational fidelity mechanism replacing incorrectly charged Glu-tRNAGln with the correct Gln-tRANGln via transmidation of the misacylated Glu-tRNAGln [1].  This activity supplements the lack  of glutaminyl-tRNA synthetase activity in gram-positive eubacterteria, cyanobacteria, Archaea, and organelles [1].	20.70	20.70	20.70	20.70	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.09	0.72	-4.18	191	3483	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	3411	33	945	2164	1701	72.20	30	68.71	CHANGED	ls-..cEhpphsppLssILcah-pLsc..lDTs...sVcPhsps........h....s.hp.........sshR-Dts.....ppsh..s...p-phLsNAPpp.....ccs.hFtV	.....................lo--EhpphsspLspIlsh.l.-.p.Lsp.l.D.Ts......uV..cPhsps........h............c..hp.................................ss.hR..-.D..hs................pp.uh...s.....p-chLp.NAP.cs.....css.hahV................................................................	0	327	621	803
+2715	PF05096	Glu_cyclase_2		Glutamine cyclotransferase	Bateman A	anon	COG3823	Family	This family of enzymes EC:2.3.2.5 catalyse the cyclization of free L-glutamine and N-terminal glutaminyl residues in proteins to pyroglutamate (5-oxoproline) and pyroglutamyl residues respectively [1]. This family includes plant and bacterial enzymes and seems unrelated to the mammalian enzymes.	20.50	20.50	21.20	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.63	0.70	-5.37	3	437	2012-10-05 17:30:42	2003-04-07 12:59:11	7	3	394	9	188	420	289	246.90	34	86.35	CHANGED	M+....L.LpphuhLsLAA...........shu.AA.VhuA+uPVht.+Vl+oYPHDosAFTQGLpYLssGHILESTGphGcSclRVa-Lcsutlptcpslsssl...FGEGlTslcspVYtLTWpDGVAapYDtcTFcsLGcasYpGEGWGLT..+DsKsLhMSsGTAFLpaRDPKTFAtpcoVQVTDpGVPVopLNELEYVcGpLYANVWQTsRIARIcPsTGKVluWIDlSsLL+Elulcuo+.sp....DDVLNGIAa.s-psRLLlTGKLWPpLFEVKLst........tN	.....................................................h..hh.........................................................................h.......t..h..cl..lpp.aPHDsp..uFTQGL....h..ts.........s............p...Lh.......E........STG...............h........h.G..p.....Spl..+.......c...h.......c....l...p...o..........G.p..........s..........h......p.......p.......hp......Lss.ph.....FGEGlTh.h......s...c......c......lapLTW+pthu.ahaDh...s..o...........h.p..............l.t.p...h...s.Y.....p.......u.......E...GWGLs.................p-...s.........p.p..LlhSDG.ospLh.......h.....hD..P..........p......s......ap.......hp.p.......l......p......V...s..t.....p......u..ps..lpp.LNELEa.l.........s..G......p.......laANlW........o.......spIhc..I-PpoGpVhuhlD...hs...sLh.t..th............t.....................sVLNGIAa.....s..p.........ps.........c............halTGKhWsplaElch....h.........................................................................................	0	80	145	177
+2716	PF04262	Glu_cys_ligase	glu_cys_ligase; 	Glutamate-cysteine ligase 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Family of bacterial f glutamate-cysteine ligases (EC:6.3.2.2) that carry out the first step of the glutathione biosynthesis pathway.	20.10	20.10	20.20	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.30	0.70	-5.96	7	1652	2012-10-02 17:21:26	2003-04-07 12:59:11	9	13	1468	18	291	1175	573	336.30	42	63.50	CHANGED	uctlthl..pppsphLppht+GlEREoLRVsssGpLuhTPHPtslGusLTH.hITTDFuEuLLEhITPsspcl-phLs.Lp-lHcaspspLts.EhlWPLSMPstlss-EsI.lAQYGsSp.G+hKplYRcGLthRYGchMQhISGIHYNFSLP.phashlhptps.ptstp-h.SuuYhplIRNahRauWll.YLFGASPAlsSuFLpsp.ppL..c+h........tpthhYhPYATSLRhSDlGYsNssptsLslsFNslppYlpulppAlcTPstpatplGlht-.GphhQLNsNlLQlEsEhYusIRPKRssppGEp.hpALhppGlpYlElRsLDlNPFsPlGIshpps+FLDlFhlaChhtDus.hDtp-htpspsNapcls	.........................s....thl...tp.t.phlpthp+GlEREoLRVs.s.-.G.p.LApTs.HPc.uLGusLTH.aITTDFuEuLLEhITPls.ssl.pchLphLpslHchst.c...pl....s.c....EhhWPLSM...Pshl.s.p.p.p.-.I.lAp..YGoSN.GphKslYRcGLtpRYGthMQ.sISGlHYNFSls.shaps.hh...s.....t........p......s.....................t.......t....st....p-...hhSstYhclIRNahRasWllsYLFGASPul..ssuFlps..c.....p...p.L.......pph..............................tt..shha.hPa.ATSLRh.S.D.LGYs.N.c.s.Qs..s..Lt.l..s.aNsLppYlsuLcpAlcss...a.tlGh.......t..s..p...hQ.l.NsslLQIENEhYusIRPKphstsGEpPscALhctGlcYIElRsLDlNPFoPlGlspppl+FL-LFhlashLs.D.us.ph.ss.s.-.htphp.Nhppl............................................................	0	62	142	226
+2717	PF01645	Glu_synthase		Conserved region in glutamate synthase	Bashton M, Bateman A	anon	Pfam-B_719 (release 4.1)	Family	This family represents a region of the glutamate synthase protein.  This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organisms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.02	0.70	-5.54	15	5264	2012-10-03 05:58:16	2003-04-07 12:59:11	12	61	3389	15	1586	7292	7907	342.40	41	29.94	CHANGED	Hh.ssths+pLppAsps..........tshssacpYpchhscc.hlsslRshLchcsscss...........lslppVEss.plhpRFsouuMSaGALScEAHpuLAhAMNclG.upSNoGEGGEssp+hcsssss.......................tIKQlASGRFGVo.............scYLssActlEIKlAQGAKPGcGGpLPGcKVos.IAclRtssPGVsLISPPPHHDIYSIEDLAQLIaDL+plN..cA.lSVKLVuptGlGsIAuG....VAKAsADhIhIuGa-GGTGASPhoulKauGlPWElGLsEscQsLhpsuLRc+VpLpsDGGL+TGtDVshAshLGA-pashGTuuhIAhGClhsRhCHTNsCPlGlATQDPcLR..t+atGsPc+VlNahhhluEElR-lhAphGap	.......................................................................................................................................p......h..ust.................p...a.ptatt.h..p..p..p..........h..t.lR..thh.thp.....t...t............l.s.lppV-.s.s.t.p.lh.p+.FssuAMSaG.u.lS...E.........A.HpsL....AhAh......Np....l.G......utSN......oGE..GGEs.st.+.h.t.s.t.t.ss.................................................................................tIKQ..lASGRFGV.s.......................stYL..s..s....u......c.tlpIKlAQGAKPGE.GG..p..LP.....Gp.....K..V.ssh..I.......A...ch....R..t...u..sP.....G.l...s..LI....SPPPH....H...D..............IY.....SI.....ED.LuQ.............L.Ia.DL.Kp.s.N....p..u...luV..K.....L...V..u......p......s......G......l.......G...s....l..A.s..G..........V.u....K....A....t......A...DhI...s....I.u..G..a.-.G.......G...T...........G........A..........o......P.......h.......s......u........l........c....a........s........G......h...P......a.........E.........l.......G...L........s......E.........s.........p.......Q........s...L....h...h....N....s.......L.........R..........s.......+...........l....p...lp...............s.D.G.tl....+T....G....t..............Dl....s....h.A....s...hLGA...-...p...a...G...huTu...s...h...l.u..h......G................C.....l.................h.................h.R..................h................C................H...h...s...s...CPsGVATQ........s.s..........p........LR................t..........c..........apG........psc+V.hN.......ahphlAcE...lRclhAplGh.t.........................................................	1	495	1024	1355
+2718	PF02364	Glucan_synthase		1,3-beta-glucan synthase component 	Bashton M, Bateman A	anon	Pfam-B_686 (release 5.2)	Family	This family consists of various 1,3-beta-glucan synthase components including Gls1, Gls2 and Gls3 from yeast. 1,3-beta-glucan synthase EC:2.4.1.34 also known as callose synthase catalyses the formation of a beta-1,3-glucan polymer that is a major component of the fungal cell wall [1]. The reaction catalysed is:- UDP-glucose + {(1,3)-beta-D-glucosyl}(N) <=> UDP + {(1,3)-beta-D-glucosyl}(N+1).	24.30	24.30	27.70	26.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	818	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.59	0.70	-6.67	9	769	2012-10-03 03:08:05	2003-04-07 12:59:11	10	21	230	0	498	771	22	530.20	35	43.68	CHANGED	-FFPssSEAERRIoFFAQSLuTPlPEPlPVDsMPTFTVLlPHYSEKILLSL+EIIRE--.hS+VTLLEYLKQLHP.sEW-CFV+DTKlLu-Essh.psstp.pc-p.............................t.hppKhDDLPFYsIGFKsAsPEYTLRTRIWASLRo.....QTLYRTlSGFMNYS+AIKLLYRVENP-lsQhFuGNs-tLEh..EL-cMApRKF+hlVSMQRYuKFs...t-EhENsEFLLRAYP-LpIAYLDE-Ps.pputEsphYSALlDGasEl.-.NspR+PKaRI+LSGNPILGDGKSDNQNHulIFYRGEYIQlIDANQDNYLEECLKIRSlLuEFEEhphssssPYsssht...p.pspPVAIlGAREYIFSENIGlLGDlAAGKEQTFGTLFARTLApIG.GKLHYGHPDFLNuIFMTTRGGlSKAQKGLHLNEDIYAGMNAhhRGGRIKHsEYYQCGKGRDLGFGSILNFTTKIGoGMGEQMLSREYYYLGTQLPlDRFLSFYYAHPGFHlNNlFIMLSVQhFMl..lLlNLGuLp+pshsCpYDps...pc..hP......GCYNL.PllpWlpRsllSIFIVFaIoFlPLhVQELhERGha+AhhRhh+HhhShSPhFEVFsCQlYupulhssLsaGGARYIuTGRGFATsRlsFuhLYSRFAssSIYhGucshLhLLFuoho........lWhstLlaFWlolluLClAPFlFNPHQFuWsDFFlDYR-alRWLoR..GNS+.+tsSWlsasRloRoRlTGaKp+hlu..s-ctshDssRAphpNlhhuElhhPhhlhhhshlsYhFIsSpsGss................ppsossllRlhIlshhPIhhshslhhhhhhhusshGPhhs	.....................................................t.-ApRRltFFspSL...h...hs.....s...lptM.s.a.ol....hhPaYtEphhhs...................p...................pl....................................p.............p......ptlohl.YLp.p..........la...............-WtsFhpch......t....................................................................................................................................................h.hh.h..u..c...............................t........t....u.h...............................................................................................................................thpt.sthKFphh.hshQ.ht..p.............pht.....sh..Lh.........t..t.lplual..-..............................................t....t.......................t...............ha.S.h.Llcs......................................................................haplpLsG.s......s.h.lG-GKs-NQNpullFhRG-hlQhIDhN............Q.....................DsY.hEEshKhRslLtE........a....................t................................................................ssIlGhREalFots.u.Lu.hhu.pEpoFsTlhtRhhu.......................h..s+hHYGHPDhhsthahhTRG.GlSKAp+slplsEDIaA................GhsshhRtGplpHp-.YhQsGKGRDlGhspI..F.psKlusG.GEQhLSR-hahlup.hsh.Rhhohaas.p.GFa..hsshh.h.hsl.h..ahh..hhh.lss.lttt...................................................................h....hh.lhhh.hlPhhht.hhEpGhhpuh.phhh..hphushF.sF.hthhsp.h.psl.hGGAcYhuTGRGFsh.+..Fs...Yphautsphh.hu.c..h....h.h...l..l.hh.h...............................................a....hh..W...h....h....shhhu.PahaNPptFta.chh.Dappa.pWh.......s............tpo.....W.......taht.................................................................................................................................................................................................t..........................................................................................................................	0	149	330	444
+2719	PF02685	Glucokinase		Glucokinase	Bashton M, Bateman A	anon	COG0837	Family	This is a family of glucokinases or glucose kinases EC:2.7.1.2. These enzymes phosphorylate glucose using ATP as a donor to give glucose-6-phosphate and ADP.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.86	0.70	-5.65	41	1646	2012-10-02 23:34:14	2003-04-07 12:59:11	11	5	1468	6	393	2092	1039	301.90	40	91.50	CHANGED	LsuDIGGTpsRhuLhsssssp.........phpsasss-asolpshlppaLtt....ptshpp.............st....uslAlAG.Plssspsph.TNhsWslShpphppsLGls..slpllNDFsAhAhAlsh.Lsppclhplsuup......sp.....ssushullGsGTGLGlutLlhsssphh.sLsuEGGHs-FuPpsscEhtlhpaLcpch..u+VSsER.lLSGsGLsslYculsphc......shpsth..............tpsusIoptAL......sussshucpsLclFsshhGshAGsLALphsAhGGVYluGGIsP+llphlppSsFtptFpsKGRhps.hlpsIPVhllhpspsGLlGAushh.pph	......................................................................................................................LluDlGGTNARhALtsh...sssp...........................pph..c.s....a....s....s....h...D....a..s.o.......L.........ps....s...l....c...h....YLpp.......php...s.p.s........................................usl.Al.....A...s...P...l........s.....G.........D....h...l...t..h.....T...N.....p...s.....W.....s.....h...S.....h.....t.....p.h.p.p....s.....L.....G...h...s.....clpll..ND.F.sA.hu.h.Al.s.h....L.p.....p.....c.....c.....l.....hp..l.G.G...u.p...............s.h..............ts.t.s.h....uVhG..s....G.TGLGVAtL..l..p.....s....s..c....p.......a..l.....sL..PuEGGHlD......F......A......P......p..o......-......c......E..h..h..l.h.p.h.L......+tch..........GH...V.........S.u.ER..lL.SG.s.G.....Ls.s.LY.c.A.lsptc....................sh.h.spt...........................hpPt-I....T.p....t....AL..............ss.sss...spcsLslFCshhGphuGsL..A.L.....s..hGs.....h.....G.G.VY.luGGIlP.....R..hl.-....h.h...c.....s...S...s....F.R.stF....c.c...K..G...R..ap.s.alpsI.P.Val.l...h.p.s.p...sGLlGuushhp..s........................................................................................................................................................................	0	133	258	329
+2720	PF01182	Glucosamine_iso		Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.56	0.71	-4.59	317	6449	2012-10-04 00:26:15	2003-04-07 12:59:11	15	20	4109	64	1532	4440	1070	196.50	27	73.82	CHANGED	lspshAptlhpthppul.....tp...c.......up.hslsLoGGooPthlact..Lst...............................l..sW.....s+lplahuDERh.VP.scs-SNhths+ctLLs...ph....t.ls.......s.pla...h...............................................puAttYp.pplpphh....................................................FDllLLGhGsDGHTASLFPs..pst.h...t.....t.p..hlsslpts.Ppsss.......RlTLThsslss.A+plhhllsG.tsKtpslcp.shs	.............................................................h....huphhsph.l....t..hh..t.p...p.............................sp..hsL.uLu.sGuoPh.shY.ct..Lsp...h....t................................tl..sa..pp.lpsathDE......h......s...l....s.t..c......c.......s.p.Sh.t.t.h.hpcp.l..hspl...............s..ltt.......p..plp..hhs....u..st............................................shcspsppYc..p.tlpp.hs.t............................................................................................lDlhl...L.GlGs..D.GHl.....u......h......N......Pu.......osh.s.................p.t.......t.p...........tsst.h....h....p......s.....s......s.........csPpp..............t.l.....ThG..l...s.s.l...hp.A+clhll.stG.p...pKApAlpphl.p................................................................................	0	481	916	1262
+2721	PF00462	Glutaredoxin	glutaredoxin; 	Glutaredoxin	Finn RD, Bateman A	anon	Prosite & Pfam-B_3081 (Release 8.0)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.03	0.72	-3.98	279	11246	2012-10-03 14:45:55	2003-04-07 12:59:11	19	92	4174	90	3561	10294	5112	62.30	25	45.51	CHANGED	Vhlas+.....stCsaCppscplL....cphs..lt....a.phlclsps..t...phpptltphs............sh.TlPpla...l.sGc.hl	.......................lhlas+..........ssC.s.a.C....t....ps....+phL.............pp..pG......lp...........a..p.l..s.lpps...s................phc.p.t.lt.phs..................sh..T..l..Pp..la...l..ssphl............................................................	0	1009	2074	2907
+2722	PF04399	Glutaredoxin2_C		Glutaredoxin 2, C terminal domain	Kerrison ND	anon	COG2999	Domain	Glutaredoxins are a multifunctional family of glutathione-dependent disulphide oxidoreductases.  Unlike other glutaredoxins, glutaredoxin 2 (Grx2) cannot reduce ribonucleotide reductase.  Grx2 has significantly higher catalytic activity in the reduction of mixed disulphides with glutathione (GSH) compared with other glutaredoxins. The active site residues (Cys9-Pro10-Tyr11-Cys12, in Escherichia coli Grx2, Swiss:P39811), which are found at the interface between the N- and C-terminal domains are identical to other glutaredoxins, but there is no other similarity between glutaredoxin 2 and other glutaredoxins. Grx2 is structurally similar to glutathione-S-transferases (GST), but there is no obvious sequence similarity. The inter-domain contacts are mainly hydrophobic, suggesting that the two domains are unlikely to be stable on their own.  Both domains are needed for correct folding and activity of Grx2. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with GSH in cellular redox regulation including the response to oxidative stress.	25.40	25.40	27.40	26.30	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.31	0.71	-4.57	23	734	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	698	2	76	308	10	128.90	53	61.06	CHANGED	scltsWl+cssshhspLlhPRasphsLsEFuTtsAppaFppKKEstlG.sFsptLscosphlpplsstLppLssLlt.ssptsNt.pLohDDIhLFPhLRsLTlV+GlpaPscVpsYlcphuptopVsLh.sshAl	..............PAIE-WLRKVsGYsNKLLLPRFAKu..u.FcE..FuT....PuARcYFlcKKE...ASsG.sFsshLA+Ss.uLIKpIucDL+tLD+LIl..pPNAVNG..ELSpDDIpLFPLLRNLTLVAGI.pWPo+VADYRDNMAKpTQINLLoohAl..........	0	19	32	56
+2723	PF03157	Glutenin_hmw		High molecular weight glutenin subunit	Mifsud W	anon	Pfam-B_2180 (release 6.5)	Family	Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues.  High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterised by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm [see 1, fig.2].	30.00	30.00	30.20	30.00	29.60	29.90	hmmbuild  -o /dev/null HMM SEED	772	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.86	0.70	-15.05	0.70	-6.26	2	1571	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	61	0	1	1570	0	130.40	21	95.07	CHANGED	S.VAtQYEQplVsPKGGSFYPGETTP.QQLQQtIFWGhs.thlptYYPSVTSPpQsSYYPGQASPQpPGQGQQPGphQpsGQGQQhYYPTS.QQPGQhQQ.tpGp.GYYPTS......LQQPuQGQQ.GQGQQG.........YYPTSsQhp.GQhQQPsQGQ...Q.GQGQ...QPtQGQQPGQhQQG..P...ppP......QQLGQGQQ...PsphQQSGQGQ.GaYPTSLQQ.GQGQpGaY.sS...................QQ........QPuQGQQGp.PuptQQPGQGQ.GaYPsS.QQsGQGQ.GaYPsS.....Q.QpPGQGQQGQ..........PuptQQPGQGQ.GaYPsS.LQp..GQ.GaY.TS.QQ.GQGQQ.GQ......GQK.QQPGQGQQsGQG...QQP...pQtQQPGQGQ.GYYPTS.QQsGQGQ.....QQ.GQGQ.GYYPTS..QPGQGQ.Ga.PsS.QQPGQGQ..........GQ.GQp..................................QQPGQGQpP...pQGQQPGQGQQG...............YYPTSPQ..................QPGQGQ.........QLGQGQQGYYPTS.QQPGQGQQPG......QGQpGahPhSPQ.o......GQGQp.GQh.QPGQGQQGYYPTS.QQsGQGQQ.GQh.QsGQGpQ...P......GQGQQSGQtpQGY.SsYHVSsEpQAAS.hVAKAQQ.AsQLPshCRhEGGDALSASQ	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+2724	PF00745	GlutR_dimer	GlutR; 	Glutamyl-tRNAGlu reductase, dimerisation domain	Bateman A, Finn RD	anon	Pfam-B_544 (release 2.1)	Domain	\N	22.90	22.90	23.40	23.20	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.10	0.72	-4.07	164	2994	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	2895	1	730	2124	424	100.40	27	23.41	CHANGED	tpAEtIIp...pcsppFhphhcsh.p....ssPsIpslRppucpl+cpElc+uhpp...ht....hsccs.ccslcphscplssKllHsPstpL+p.su.tpsc..pph.....lphlpplFs..l.....c	....................pAcpIls...pEsppFhpWlcsh.p........ssssI+slRppAcplppcplp+shpp..ht..........hup.cs....cpllpc.hscplsN+llHsPotpL+phu.pc...sc....sph......lphlpplasL.....................	0	231	487	639
+2725	PF05201	GlutR_N		Glutamyl-tRNAGlu reductase, N-terminal domain	Finn RD	anon	Manual	Domain	\N	21.50	21.50	22.70	22.50	20.40	21.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.89	0.71	-4.63	172	3200	2009-09-11 08:11:09	2003-04-07 12:59:11	10	10	3083	1	803	2306	768	149.10	37	35.09	CHANGED	lGlsH+sAslclRE+luhss.pphtp..hht.pl.tt..slp....EsllLSTCNRsElY....h..ssp.................h............................phlsp.htt.ls...hp.p.lppthhhhp...spcAlcHLa+VAuGLD....ShVlGEsQILGQlKpAaphAp.....ctsssuthLpplFppAhpsuK+VRo-Ts	.............................................lGlsH+TAsVslRE+lu.Fss...splpp........ulp.pL....h.......p......p.......t....lp......................Es.ll.LSTCNRoElY.........s.....ssc..p...................psttp...t.lh.....................................................caLuc.hpt..ls.............hc.-..lptp.l.a.h.hp.s.s-Al.cHLhRVAuGLD........ShVLG.....EsQILGQlKcAathAp..........c.sts..s.u....shLp+LFppuhssAKRVRoETt.........................	0	265	544	705
+2726	PF02595	Gly_kinase	DUF168; 	Glycerate kinase family	Mian N, Bateman A	anon	COG1929	Family	This is family of Glycerate kinases.	20.20	20.20	20.20	20.30	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.13	0.70	-5.76	6	4076	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	2802	4	574	2648	422	345.30	42	97.58	CHANGED	MKIlIAPDSFKESLSAhEsApAIcpGFcplFP-AsYlslPlADGGEGTV-ullsATpGphhchcVsGPLG-p.VsAhaGhsGDG+TAlIEMAAASGLtLV..Ps-KRNPLlsTShGTGELIttAL-sGAcpIIlGIGGSATNDGGhGMlQALGsphLDusGptlGhGGusLuplAcI-lssLDsRLtpsplcVACDVsNPLsGspGAutVFGPQKGAossMVppLDpsLuHaAcllccssGhslpshsGAGAAGGMGuuLhshLssclKuGIpIVhctlpLtptlpDA-LVITGEGRIDuQSlpGKsPlGVApsAKpashPVIuIAGslscDhsVVapaGIDAlFSIlsthusLc-ALpputssLhpsApslAssLthuts	.....................................................................................................................MKlVIAPDSFK-SLoA.psupAIcp.Gh..................p......p......l.h..............P......c....A..........p.................h.......l....p......lPlADGGEGTl-.u.hh....t..A.............s....t......G...p.....h.......h....p...h.p......V.suP....h.Gct....l..............p........A...h.......a..G..h..............................s...............c.....s...........p..........T.......A.....lIEMAsAuGLp..Ll.....s.........p...........p...R.....sP.....L.h....s...o..o.hGs....GELItp..AL.c.p....G.......s.c.c..............I.llGlGGSATNDGGsGMhpAL.Gs....c..h..h...........Dt.pG............p...........l..s..........s...............G.us.L.t.....p...lsp.ID...h.........s.t...h..........c...s.....+....L.......p.......p...s.......pl.pl..As..DVs..NPLsGtp.GA.o.tl...FG..P...QK.........G.........As........p..h.l.tp....LDps..Lppa.uc.ll....p.....p........t...................h..................t.................h................s.......l..............t.....p..........hs..G.uGAAGGhGuuLhu.a..h........s........A........plpsGI-lVhc....h....h....pLcptl...p.....s.......A......D......L..VITGEGR.lDpQohh.G..KsPlGV.A.p.hA..+..p..h.....p.....h..P.V..Iuls..Gs..l..s.c..s...h....t........h......lh..p...t.G........l.s.AsFul...l......t......h......sLpcs..h..p..p..u..t..p..pl....p..s.u.psluthh....t.............................................	0	175	336	474
+2727	PF01228	Gly_radical		Glycine radical	Finn RD, Bateman A	anon	Prosite	Domain	\N	22.20	22.20	22.20	22.80	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.25	0.72	-3.68	141	5415	2012-10-01 23:28:04	2003-04-07 12:59:11	16	8	2388	24	579	3783	69	105.20	42	16.10	CHANGED	husGssPhpG.....tDtpGshAsl.sS..luKlsa.thtpsGhhhshp..hssssl...p.........p.cpthpslsshlcs........aa......p.......................sGhHl.phNVls+.......csLh-AtccPEc..Y.sLslRVuGYus.pFs	............................................................usGusPhpG.....tDppGsh.A.sL.sS...VuKL............sh..sh..sps..G..l....h.shp...lsPs.sLst..p...........s.-sphppL..ssll-u..........aF...c........................GGpHl.NlNVhsR...........EsLhDAhc.......H..PEc..YspLslRVSGYuVpFs....................................	0	177	347	474
+2728	PF00232	Glyco_hydro_1	glycosyl_hydro1; 	Glycosyl hydrolase family 1	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	455	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.66	0.70	-6.29	13	11445	2012-10-03 05:44:19	2003-04-07 12:59:11	13	39	2849	314	2628	8499	1126	399.30	33	95.89	CHANGED	hptsFPccFlWGsATAAYQIEGAapcDG+G.SlWD.....sFs+p.Ps+shssps.GDlACDpYHRaccDlpLhpclGhpsYRFSluWsRIhPpG..sGtlNptGLcaYc+LlDtLhppGIpPhlTLaHWDLPQsLpD.tGGWts...RsslctFpcYAcssFccFGD+VKhWlTaNEPhssuhhuatsGhauPG..............hpshpssapsuHplLlAHAcul+ha+-hh....sGpIGlslssshthPhosus.-s.cAu-RthpatssWFh-Plh+.GcYPpphhchhtcp........uhhsshs-pDhcll...psshDFlGlNYYoophhpsps.....psh.s.spshthspts................oshuW.hh.P.GL+cLLphlpccYsp..hsIYITENGhuhpDch.p.....uplpDstRIsYlppHLspltcAI.pDGlsl+GYhsWSLhDNFEWspG.YscRFGllaVs.....hsoppRpsKcSuhWYppllpsNGh	.............................................................................h...thPpsFlWGuAsu..A.Q.........hE..G....u..h..p......t...s...G...+..G.............s.h...h.D..................................h.h.h.......p...................t..............t.......h........h............t....t...........................................sc.................u........D...a.Y.........c..+..Y..c........-...................D.lt.Lh.t.......c..hG...hpsaRhSIu....W.........oRl.....h...P..........p.........G..............p...s.......p......s..............N..p...tG.lpFYcplh-c.....h...h.p.h..................s..Ic.PhlTL..............H.......a.....-.h.P.............................t.............L.......................p.....h.................G...........G.Wh.s...........+.c..h.l........c....hFhca.Ac..............hsFppat....c+.........V.........+aWhTaN.E..........s............h..........h.......s.......a.......h......h.......u.......h....h.......ss...........................................tt.s.....p..t.ha...p.s..h....H....p...hlApAhA.........schh...+ph............................ps.p...lGhhl.s.h..s..........h.......YP......h.s....s....p..s......t....-....h.............A....t..........p...................h....................p.......t......h.......h...........................h...........a....h......D..s..........h.........t..G.p.Y.P..t...h..hphhp.cp................................s.h.....p..h..p..t..tD....h.p.h.l................p.s...s...sDaluhsYYhst.hs.p.st.....................................t.............t...s....t........h.....t..h...............................s.s..h..h......t..o.....p....h......s.W.t.I.....P......G..l...h..hl..p...l.hcc.......Yt......hsl.alsE..N........G...................h...G.s......-..p....t.......................tstl.p.Ds.h.RIp..YlppHl.p.thtc......A................l.....t.....-G.ssl.hGYhsWu.h........h......D.......h................Sh.s.s..G..hp.c.R..YGhl..aVD................sshpRh..K.cSh....h....WYpplltspt.t.................................................................................................................................	2	642	1346	1995
+2729	PF00331	Glyco_hydro_10	glycosyl_hydro3; 	Glycosyl hydrolase family 10	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.41	54	2356	2012-10-03 05:44:19	2003-04-07 12:59:11	15	132	632	164	770	2484	350	243.90	30	61.72	CHANGED	oLcphhpsph..hhGsAlsts......hhst....ppttllp..pcFNplTsENpMKh-ulpsscG..........................pFsFssADplVsaAppNshtlRGHTLVWHs..QhP....sWhtp.....sss.ss..............LhptlcsHIpsVhs+YK.......plhuWDVVNEshs-ss..........thRp.......SsahplhG........p-alchAFphARcADP......sAKLahNDYNh-ps.....sK.spslhshV+chp.scGlP.......IDGlGhQsHlsssts...........splppulptauslG...h-ltITELDlps.t.................................tpApcYpplhphhhp........phsulThWGlsDstSWhss.............................stPLLFDssapsKPAY.ullssh	.................................................................................................................................thh......t....a.s..hs..tNthK........hts..t..s............................h...s..a.t.......s...-..h..ht....hs.t......tp...s.......h........h.+...uH...sl.....h.....W.ts......p...s.............t..Wh.t............t..t...................................................hht.....hh.p.pal..ps.l.ht+.at................hhs...WDVV..N.Eslssss.....................shR.p.................................o.h..a.hp...hhG...............p-a...lt...hA..FchA+....psDP.......................sApL.......ah......N......D....Y.Nhpps.........sK...ppth..h...p.hl.c.p..lp.......p..p.G.ls....................I.D..G......lG.h..Q.....uH.h..........................t.h....t.t...hpt.h.s........t...........h......s...h.l.hTEh....Dlt........................................................st...htthh.t..hht....................h.slhhWsh.p..................hh.t...................................h...............................h............................................................................................................................................................................	0	311	563	699
+2730	PF00457	Glyco_hydro_11	glycosyl_hydro6; 	Glycosyl hydrolases family 11	Finn RD	anon	Prosite	Domain	\N	21.60	21.60	22.70	22.70	19.30	21.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.50	0.71	-4.95	12	815	2012-10-02 19:29:29	2003-04-07 12:59:11	12	49	338	104	256	868	0	165.60	49	64.32	CHANGED	GssuGhaYphWsDsGussshhss.GGsaSssWs..NtGNhVsGKGWssGo........sshslsYsusas.PsGNSYLsVYGWTpsPLlEYYIV-saGoYcPsus.spthsoVsusGuTYDIapTTRhNpPSIpG.TsTFpQYWSVRpoKRosG........TlosssHFsAWtptGMshG.phhYplhAsEGYpSSGSAslsl	............................tsshaaphWp.D.ss..u...s...s.p.....h......s...........s...........uG..paospWs.....s.s..uNalsGKGWpsGs..................................tpslsY...s...u...s.ap......ssG...N....u....YLulYGW.......T.p......s........P........L.......lEYYIVEsa......Go.Yp....P......su......s....sp..............h.GoV....ooDG.uTY-IYposRhN.tPS..I..p..G...TsT.FpQYWSVRps...K.Rs..tG.............olohu...sHFsAWtp..hG........hp...lG....sh...a..hlss...E.G..Yp....S.SGsusls..............................................	1	85	169	226
+2731	PF01109	GM_CSF		Granulocyte-macrophage colony-stimulating factor	Bateman A	anon	Sarah Teichmann	Domain	\N	20.10	20.10	20.10	21.20	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.63	0.71	-4.17	7	64	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	42	5	16	68	0	118.90	55	84.06	CHANGED	APTRsPssVTRPWpHVDA.IpEALSLLNpopDssAsMNc.sV-VVS-.F-.QcPTClQTRLpLYKpGLRGsLT+LcGsLTMhAsHYcpHCPPTPETsCtTQhITFcsFK-sLKcFLFsIPFDCW	...............................APT+.PussTpP.WpHV-A.IpEAhpLLN.SpDssA.MNc.sVEVVSEhFD.QEPTCLQTRLcLYcpGL+GSLTcLcGsLTMMAoHY+.........pHCPPTPETSCtTQhITFcSFKEsLKcFLh.IPFDCW........	1	1	1	2
+2732	PF01670	Glyco_hydro_12		Glycosyl hydrolase family 12	Bateman A	anon	Pfam-B_1736 (release 4.1)	Family	\N	20.80	20.80	24.10	23.40	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.44	12	532	2012-10-02 19:29:29	2003-04-07 12:59:11	11	21	280	62	289	492	9	154.30	26	54.07	CHANGED	.spsl.hhVuslpShsoslsauh.ssosl.sssAYDlahssss..pssusGchElMIWhsphGslpPhGspluTsol....sGp....oW-lWhG.....hsus.psauaVssoshsshphDV+cFhchhspspuh......stsshYlpshphGTE.ass.....ssshslssaSssVp	.............................................htluslpo..hsosh..pa..sh....sss...slh.s.ssAYDlahs.....s.s.s..............t.....s....u..s.s.p....hElMlWlst...hG......s......h...t...P......l...........G......s.................l.....u......s.s.sl...................uGp..............sap..lapG..........s.s.u.sh.pVa.....o.a.l.........s......s..........s...s....h........s...sas.s.........D.....l.........ts.....F...ls........h..ts..s.p.sh............sss..YLs..........slphGsEs.asu.......ssshss..sp..aohtl.............................................................................	0	99	184	259
+2733	PF01373	Glyco_hydro_14	Glycosyl_hydr22; 	Glycosyl hydrolase family 14	Bateman A	anon	SCOP	Domain	This family are beta amylases.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.45	0.70	-5.73	5	548	2012-10-03 05:44:19	2003-04-07 12:59:11	12	11	191	66	172	752	23	308.80	44	78.16	CHANGED	aVMGPLcKV...TDWN...oFKsQLpTLKNNGVYAITTDlWWGYVEsAGDNQFDWSYYKTYAsoVKpAGLKWVPIISTHpCGGNVGDDCNIPLPSWVWoKsSsD.-MQFKDESGpsNsEuLS......PlaSGls..KpYsELYuSFApNFuuYK.DlIsKIYLSGGPSGELRYPSYsPSsG.WoYPGRGKFQsYTEsAKSuFRsAMpsKYGSLsKlNuAWGTsLTShS..QIsPPTDGDsFaTNGsYNSsYGKDFLoWYQSVLENHLulIGuuAHssFDsVFGV+IGAKIAGlHWQYNNPTMPHuAEpsAGYYD......Ys+LlcpFKcucLDLTFTCLEMsDS..GouPpYS..hPpTLVcsVuolANsKGlcLNGENALspGsSu.tFp+ltEclTsauauG.....FTLLRlNNlVNsDGSsTuEMusF	...........................................................................................................................................................................................................lhSFHpC.GG.NVGD.s......ssIP.lPpW.Vh-h...s.....tp..........s.sDlhaTs.....+.....t.....Gp...RNhEhLohGs..............Dp.Plh.......p.GRTslphYsDaMtSFRps.h.pp..a.h...su......sIs-IpVGhG..PuGE..hRY..PSY.P..p......u.p....G...W...h....a.................P.G.....l..GE....F........C...YDKYhpush.+sAAt.....................Wth.....s.....s.....s..s..st......YNshP....c..c..T.t....F.F...p..p........s....G....s...a...oph...G..+....FFLsWYSshLlpHGD+lLstA.p..pl.......F............u.....s........t.................Vp..l.uh..Kl.......uGIH.WaYp....s.sHssEhsuGahs.......................Y..lh...thh..tp..........t.......h.h.hss..h..-...hp..s.................s.....PptLl.plh..s...t...h.h....tsEN..u.....h.....h.....s...th.......tph...................................................hsh.ph..................................................................................................................	1	48	111	143
+2734	PF00723	Glyco_hydro_15	glycosyl_hydr10;	Glycosyl hydrolases family 15	Bateman A	anon	Pfam-B_771 (release 2.1)	Family	In higher organisms this family is represented by phosphorylase kinase subunits.	21.70	21.70	21.80	21.70	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.47	0.70	-5.93	26	2515	2012-10-03 02:33:51	2003-04-07 12:59:11	16	24	1317	16	1160	2459	281	390.30	19	61.49	CHANGED	uhttpthhpslts.thhh.ss.oGhllASsopotP..........DYhasWsRDuuhshtulh...............ctht.thppsltphhcs.hlps.hphputsps.sphpss...sLttstapsstsshsGs..WG+.QhDusuhhhhslhph......htsG..........thpssl..l...lps.lpYlsptWsps..saslWE....pppupp.a..opsstt+AllcuhshActhG..s.................................................ssph..hppptsplhspl.......p....ua..........................Wssttsahthsss....................ppsLDush..............lLhshhsasssss...................s+hlushhhlhss.hpsthhlssu..ts........ltR.YspDsh....................................................................t.ht.sGsPa.................................................aLsohh......................................................................................................................................................................................................................................................................................................sp.hhstlhthsuptt.htlschuhshacchsss.................su...p....pt.h.sh..s.tthss.hhphht..ssssGhLuEphsh..........hpGp..huupshsaSasshlpsuh	...................................................................................................................................................................................................h......h.p....hh..hh.h.hh....ts.sGsll.A..u.so....tshs....................cYph.sWlRDushshh..ulhthu............................tp..th.h....h.h..........tp....s.....h........h.........t....................p.....t............lp....hht..h.tsp..p.h...tp........................hh...thts.s...t.......s.s......h..h..G..s.......t......hsphQhDs.hu.hh..h.l.hth.................................hpts.......................hth.tp...h.th..........l.pt....h....l....ta....l.......t......p......t......a...p......t......s........D...GlWE.........pts.p.ph...Splhhh.hA...h.c....uhp..h.h.p.h.h.s.....ts........................................................................................................h.ph.....hpt..ht.pp.lhppl.............hpp..........ua...............................................................................................................................................................s.........h..h.a...h.t.h.ss.........................................ptlDush.......................................................................................lhhs....h..t...h.h.ss.s...c......................................................sphhs.sh.h.l.tp.....L.....h..t....t.t...h.................................................hhR..Y.....t.p.............................................................................................h.........t..ttsa.......................................................................................................................................................................................................hh.sshh.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	366	666	954
+2735	PF00332	Glyco_hydro_17	glycosyl_hydro4; 	Glycosyl hydrolases family 17	Finn RD	anon	Prosite	Domain	\N	24.00	24.00	24.10	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.10	0.70	-5.39	16	2142	2012-10-03 05:44:19	2003-04-07 12:59:11	13	28	364	18	1056	2132	103	250.50	30	66.00	CHANGED	IGVCYGhhuNNLPuss-VVpLY+opsIpcMRlYpscspsLpAL+GSsIpllLsls.NssLtsLAus.otAssWVpsNV+saass.Vph+YIAVGNEVssusspu.....llPAMcNlpsALsAAGLuspIKVoTulphsllsNoaPPSsGsFpsssh..hlsPllpaLssssuPLLsNlYPYFuausNPt.slpLsYAhFpssssss.Ds..uhsYpNLFDAhlDulYuAl-KsGus.slclVVSESGWPSsGu...huAoh-NApsYspNLIsHVt....tGTP++PG.slETYlFAMFsENpKssc.....lE+HFGLFpPscpPtYslsF	..............................................................................................................................................................................................................GhshG.......s..p....s.ttsht.h.h.pt.....t.h..t..th+la.t.ss....thlpuh.t..s.o..sltlh...lsls.s.t...l..t.hss.............t....At.tWl..p.p..s....l.....a...........................s........p......hp.......hls.V.G.NE....h.......t.s.tt................llsAhp..slpt.u.....l..t.....h...s.l..t......tlp.......loss..h.t.h.shh...t....t...s.......s....P...St.u..Fp.th....hhtshh..pa.Ltps..s..u.P...hhhN.h...YPahuh....h.......s.s.......h.s.l.saAhFp....s.....s......s..........s.....h.....Ds...................tht.YpNhhD.A.lDuhhsAh...p...t..............h.....Gh.........s....s............l.............p................lll................uEoGWPo...tGs...............su..s.......h.t...s......A......t.sasps..Ll..p.+.lt....................pG....T..Ph....p......P.s....sl.....p.....sYl.F.uhFsE....s..K.....s.....ss..........sE+p.aGlF...s.s..t.p..hY.l.............................................	0	163	606	854
+2736	PF00182	Glyco_hydro_19	chitinase_1; 	Chitinase class I	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	20.50	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.61	0.70	-4.69	17	2104	2012-10-03 00:09:25	2003-04-07 12:59:11	14	48	920	28	497	2044	184	174.20	31	58.88	CHANGED	IlopuhF-pMLpaRNssuCsuKGFYTYDAFlsAApuFPuFGso.GDsss+KREIAAFhAQTSHEToGthhhus-usauWGYCahpp...........sptpaPCusG+cYaGRGPIQLoaNYNYG.AGp..AIG.DLLssPDLVuoDsslSFKTAlWFWMTsQss.KPSsHsVIsupWpPSssDtuAsRlPGaGsITNIINGGlECspG.psspspsRIGFY+RYCshLGVssGsNLcC	............................................................................................................................................a...shtthh.tAh..t......a.......t......h.s.....t................s...........t......................t.....++pl....As.hhu.phspE.Ts....t...h........h.......h..t.....................s.......h..................t............................s..................hs....................................................h......................p....t....p.....h............s........s......s.......s.....G.....p.....p.....Y..a...GR.G......slQ.loapa.....N....Ys...ss.....Gc............u...l......u....h......D.........L........L........s.s.......P-......l......V..up.........D....sh......l......uhpoAl.WFW......hss..........................htsh......t...............................G.................a..G..hhphl.Nss.pCs......................t..........t....pl....tha..hht.....................................................................................	0	116	292	404
+2737	PF00703	Glyco_hydro_2	glycosyl_hydro7;	Glycosyl hydrolases family 2	Bateman A, Griffiths-Jones SR	anon	Pfam-B_572 (release 2.1)	Domain	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.59	0.72	-3.61	136	6352	2010-01-08 13:56:32	2003-04-07 12:59:11	16	146	2285	323	1491	5735	464	105.70	19	11.70	CHANGED	spl.p...s........hhlpsphsp....ppuplplpl..............hpstsstshphplpsphhssstpphtt..sstthhhhttt.......................h.h.ps..pLWss....c.p..Pp.LY..slplpl.....tss.....phh-ph..ppphGhR	.....................................................................................l..t...s............hh.l.t.s.p.hspt.......ppuplph..pl......................s........t...t...t.....s.....t...p.....h....p....l...p..h...p......l....h.....s.sp.s.....p.hs.ss.........sptths...................................................................ph.pl.p.sP.....cLWss.......-p.P.h.LY..pltlpl........tss...............phl..-th...spphGhR......................................	0	531	1045	1312
+2738	PF00728	Glyco_hydro_20	glycosyl_hydr11; 	Glycosyl hydrolase family 20, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_877 (release 2.1)	Domain	This domain has a TIM barrel fold.	20.60	20.60	20.60	20.70	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.32	0.70	-5.29	56	4091	2012-10-03 05:44:19	2003-04-07 12:59:11	17	134	1587	80	1175	3510	693	323.90	22	49.19	CHANGED	FsaRGhhlDsuR.pFhshcplc+hIDtMAhhKhNphHhHLoDs.......puWplpl.....psaPcLochGuhpspt.........................................................hYTpp-lp-llpYAttRtIcVIPEIDhPGHstusltuhsphttt.........................thphtssp.hlssspspoapFlcslhcElsphas......spalHlGGDEs...........................tspWppsst...hpthhtptt...ts..............htph.th........h.t+htphlpptGpp....hlsWs-hhpss..................................ssspshl.sWps............st.stphs.............ppGaplIhoshs...hhYlDhhtsttst..sh..............h.shpps...................hsasshhpt.s..........stptt...........tlhGspuslWsEhl.......ssspl-hhlaPRhhAlAEtsWoss	....................................................................................................................hRGhhlDsu.R.p.ah.sh.........ptlcc.hl.Dhhuh.hKhN.thHh..HlsDs...........................tu....a.t.hpl..........p.thPt.....hs.ph.....sshps.t............................................................................................................t.hYTpp-hp-llpY....A.pp+................sIpllPEI-hP............GH......hp......u......h..l..tu..h.sc..hhtt.......................................................................tht.h.ts......t.......t..hls.....s...p.p.p.sh.p.Flc.sll......s-l..h....p..h.Fs...................sphhHlGuDEs................................tss.a..tt.s.....t.....hpthht..p...t......s..........................tpl..s.h........a.h...p..cl......t..p.h....l......p....p.....p...Ghp.......hhsW..s-.hhhtt...............................................sps....s..h....l..hWps......................ttshphs....................................................................pp.G.a..ch.....l....ss.p........hhYh.shhtt...................................................................pth..............................................................................................ph.ps.h..t..t.......................p.....................................lhGs.ss.hWs-..hh................stp.......h...p....hhaP...p...h.uh.AEh.Wp..t.........................................................................................................................	1	455	732	999
+2739	PF02838	Glyco_hydro_20b	glycosyl_hydr11; 	Glycosyl hydrolase family 20, domain 2	Bateman A, Griffiths-Jones SR	anon	Pfam-B_877 (release 2.1)	Domain	This domain has a zincin-like fold.	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.78	0.71	-3.58	143	2321	2012-10-01 20:56:08	2003-04-07 12:59:11	10	128	932	72	547	2311	319	127.00	21	15.90	CHANGED	ph.sllPtPppl..p.h..tsGs....asls..s.s.sslsh..ss....ts....pt..s.....s....p.h.Lpph.l.p.......ttG.h..phs........tss..sss.........p...ssl..............t.......ts...................thhspEuYtLs.lss....s.....slsltussssGhFaGhpTLtQll..ttt...........ttt........pl..s.ss.pIpDa	.......................................................................................................tllPtPp..pl..p.h...tpGp.....hs.l...........s....p..s..splsh..ss...........t.......tps...............s......p.hL.tph..lp...........hhGh....pht...............ss.tss..............p.ssl.......................h..........s.............................................................sth.ssE...uYpLs...lss....p.........tlplpus.s.ss.GhFaulQTLhQLl..sst..............................ttt...........pl...P..ss..pIpD.............................................	0	198	366	481
+2740	PF01183	Glyco_hydro_25	Glycosyl_hydr18;	Glycosyl hydrolases family 25	Finn RD, Bateman A	anon	Prosite	Family	\N	27.00	27.00	27.00	27.70	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.41	0.71	-4.46	28	3628	2012-10-03 05:44:19	2003-04-07 12:59:11	15	150	2015	18	613	2804	137	177.30	24	50.67	CHANGED	lDVSpaQusls...aspl.....ppsGl..phshlKATEGssahsshhspphssucssGlhhusYHFhp.s...ssAtppAcaFlssl...thssssh..sLDhE..............tphssstpssssthppFlcpl.cpptGh+sll.YosssFhpsp...hsph.spa..sLWlApYsspssss..........shsshshWQYTusG.hsGl	..............................................lDl.SpaQ....u....p.ls........appl.......................t.psG.h........pashl......+.....s......o......c.......G...........s.........s........h...........h...D....s...t...........app...php..p....upp....t......G...l...h.G.sYaasps.................ss......u.pppA.c..h...Flpps...............shs.ttsh..........s..lDlE.................................t.s.hst.sshpp.tl.p...s...ahspl...p.....p......t...s.....G.....h...p..s.h.l...Yos...t.s...ahpp...p.......................t........s...p.h........sph..............slW.lAp..Y.ssp....s.h...........................ts..hsh.WQaospGphsG....................................................................	0	217	409	506
+2741	PF02156	Glyco_hydro_26		Glycosyl hydrolase family 26	Mian N, Bateman A	anon	IPR000805	Family	\N	20.20	20.20	20.20	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.19	0.70	-4.95	8	834	2012-10-03 05:44:19	2003-04-07 12:59:11	10	61	453	23	298	816	38	238.10	19	51.41	CHANGED	VsPNAptss+sLhsaLsslhs...++lLSGph....Guhs.sshshp-hpplpssTG+hPAlhuhDahc..hosupltcshsssss.p-hIsaW+..pG.GIlslshHas.......sPup..pts.sFhTtsTo.phcsslsss.osEY+.hlhc.lDpIA-tLpcLQsps...VPVLFRPLHEssGcWFWWGscG........PcsYKpLW+hlY-hhsch+GLsNLIWVYosss..s.tssa....YPGDsYVDIlGhDsYts..Dstshos.asphlsLhsutthstluE....sGolP.sthIsshchpas...aF.sWss.........phshsssptlpclapssaVls+DE	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h....t...l.s...t.h....tp.l.p..s......s........lPlla.R.hHEh.........s........G....s............W..F...WW..G..t.p....................sptahp..ha+h...hhch.hp..pt....p.sl.....s.Nll.a....s.....a......s......s......s....s..............................t........s............s.....s.....a..........YPG..D.....sYVDllGhDsYst.............s.......s........t.....t......................a..tp....h..h...t..................t....................ht..................................................................................................................................................................................................................................	0	140	222	272
+2742	PF00295	Glyco_hydro_28	PG; 	Glycosyl hydrolases family 28	Finn RD	anon	Prosite	Domain	Glycosyl hydrolase family 28 includes polygalacturonase EC:3.2.1.15 as well as rhamnogalacturonase A(RGase A), EC:3.2.1.-.  These enzymes is important in cell wall metabolism.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.09	0.70	-5.48	16	3587	2012-10-02 14:50:22	2003-04-07 12:59:11	12	63	822	30	1506	3608	74	283.30	21	67.90	CHANGED	CushshsslhVPp..shtLc.sshs......uuholphpGTsphs..........hcp.ph.....hhhlsssplsshsssG.usIDGpGs........tWWcspsp.....ssKstPphlphppsc.suplsslslpNo..hthslptssslshsclsIssssss.............NTDGhclusSsslpIssssltstDDCluIsoGo......slphTsssCusGHG..ISIGSlGspss.ssVssVsVpssslssosNGVRIKT.hp..uuoGoVoslpapNIphpsls.hsIlI-QsYps.ssPssps.souVploslsacslsGTsso.tsslhlLCucu..Cpshshsslslou.G...psoupCpNls.......ssssC	.................................................................................................................................................................................................................................................................................................................l.......h....t.h........p............h................h.........G.............u...h.....l.sG.....pGt..................................a..a.......p....................t...t............................t.................t.......P..........p..h..l.t.h........ps.p..s.hhl.p....s........l.pl..h.NuPh.a....p.h.p...h...h...t...s.p.slp.lp...slplps.s.t.ss..................................NTDGh......Dht...s.o...ps...lhIps.......................s..h.....l..p...s.........u................D..D..........Clulp...u....Gpt...........................slhlp..s..s..h..s....s.....s...G...H..G......l..ol.G...S.........sp..t...t........................................V...........p.s....l..hl.........p.....s...s....p......h....h........s..........o...........p.........s.............G..l....R........I....K.......o....h..................uts...G....h..l....ps.....lha...pslphp.........s.....l.........p..............s.......l...h.............l.......s..........t......t...........Y...........t...........s..........t.......t...................s.........t.........t...................................s..........t........h......................l.........p........s.......l.......h..........h....p....s..l...p.....u.........p.......s..t.......t..................s......h........h......s.....t.....t............h.ps.h.hpshtl...................................................sh........................................................................................................................................................................	0	359	933	1245
+2743	PF02836	Glyco_hydro_2_C	glycosyl_hydro7; 	Glycosyl hydrolases family 2, TIM barrel domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_572 (release 2.1)	Domain	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.88	0.70	-5.52	11	6947	2012-10-03 05:44:19	2003-04-07 12:59:11	12	151	2301	315	1472	6580	701	251.70	22	30.17	CHANGED	lcl+c.shhhlNGK.lhh+GVNRHEpssh+G+uhshshhlpDlpLMK.phNhNAVRTSHYPsp.caYpLCDcYGlaVlDEsslEoHGhhphhG........................sssPpW.tAhl-RhpchlpRDKNHPSlIlWSlG.NES.....suGtshcshhcahKplDPoR...sVpYEus.......s.hssphsslhhsh.uphYpc.sh.tp....lpc.lps.....................p.pKPhI.CEYuHsMGNu.GshpcYpphapph.cYQGualW-atDpul.tptss.ss....chhtaGGDFs-p.sDhpFshN..GlhhsDRsP+PuhhphKchhp.hph	....................................................................................t..t.hhl..Nsp..h..h..hp.G..h.s....h.H..p..t...t...s......h.h..G......p.s...........h..........s.....................p..........t...........hh.p.D..l..p..l..h.K...phshNulR......s....u......H......Y......P........t...s.................p.h..h...c.h.CDch.......G.lh...V....h....sE.s........s....h...........s...h...s..h...h.......ht.................................s..p..s..s....p.h.....t.....p.....s..h..h.p.c..h....pc....h..lp.Rs......+NHPSllh.WS.....lu..NEs.....................................stt.t.........h.......p.......t....h......h.......p..h.......h.......+..p....h.......D......s...o....R..............l.p.......h..t.ts.......................................................h.....t..........................s....h.................t......h.....h......t...................t........................htt............................................................................p.....s...h...h......s...E..........as..t......s.....h.........h.....s...................t...................h.....t.................................h............................................................h..............t............t.......h........h..............................t...........................................................................................................................................................................................................................h.............................................................................................................................................................................................	2	553	1041	1294
+2744	PF02837	Glyco_hydro_2_N	glycosyl_hydro7; 	Glycosyl hydrolases family 2, sugar binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_572 (release 2.1)	Domain	This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.09	0.71	-4.69	88	7272	2012-10-03 19:46:52	2003-04-07 12:59:11	13	195	2374	329	1801	6677	638	164.50	21	18.74	CHANGED	ppphhsLNG.......tWpFphssss.........................t...t..h.................thss......tta.pplsVPssaphp.sh.........................................tt............sssuhYc+pFplssph.....p...scclhlpF-GVpsshhValNGphVGh.ppsuasshEaDlTshlptGc....NplsVpVh......phssusal................................s.DhaphuGIaRsVhLhspP	...............................................................................................................................................t...h..Lss........W...pFth.tts..........................................................................................t...................................................pt.....th...p.p..l..s..V..P.s..s..aphp....h...............................................................................................................sss.s.h.....Y.p+...p.F....p....l.s.p..s..h.......................p........s.p..p....l..h..L.pF.-.G...V.p...p..t.s.p.V...al.....N......G......p......h......l...........G........h......p........p..........s...u.......a.....t.....s.....h.......c.....h...D.l..T....s....h....l...........p....t...........Gp.............N..hlsVp.V.....................p......s.s.phh...................................................s.h.a............h.....u......G..IaRsVhLhh............................................................................................	0	669	1268	1576
+2745	PF00933	Glyco_hydro_3	glycosyl_hydr14;	Glycosyl hydrolase family 3 N terminal domain	Bateman A	anon	Pfam-B_1151 (release 3.0)	Family	\N	20.70	20.70	21.30	20.70	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.73	0.70	-5.44	39	9251	2012-10-03 05:44:19	2003-04-07 12:59:11	16	142	3405	47	3184	8362	2951	295.80	24	46.55	CHANGED	TL-EKls.hs....................................hhGuhhh.........................shtpssshsRlGlPtlhs.pDustGlptt.hs............TsFPsuhulu..uoastc....LhpchGthhGpEhpu......pGlslhhuPsls.lsRsPtsG.RsaEsFuEDPh.Lsuthusthl+GlQu....t........G....VhuosKHFsu....NppEspR...................pssssslsccsl+ElaLhsFptAV.cusssoVMsu...YNplNGs..............ustsphlLsplL+c-hG.....F..pGhVhSDWh...............sspssstulpAGlDhpMssshh................ppLhpulcsGp..lspppl-csspRIlph	..........................................................................................................................................................................................................................h.u.hh....................................................t.h...t.......p...t.h..h...t...............p....h...t...l.....P.h.h.hs..hD.....t.....t.......G.h.ht.thtt..................................................ThaP.....s....s..h.u........h...u.....u....o..a.....s...c.......................ls.p....p.h....G....p....h.....h.up....E...h.pu..........................hGl.sh.s.h......u.P.s.l.....s...l..........s......+.......s...s......p......h.........s....p...s................c.u.a.u....-.DPh.lsut.hut.s.hl..cGhQs.......t...............................u...l..h.us..s..K................H..F.suh........sss....-...s...p+....................................................................p.h..s...s..s..s.h...s..t..p....p..l..p...p...h........h........PF.cts.l..................c.....u....s.....s.........s.......u.........l..Msu..................a.....s......p.........l.....s..u.p..........................Pu.st.....sph.ll..pslLR..p.....c.....h..G..............F...cG.......h...l..h.S...Dhh...s....h..t...t..h.....h.................................htcs.s..h.t.ul..p.....A..G.s.Dh...h.ss...s.th............................................................ptlh...p..t..l........p...p..Gp..........l..s.....t...plspust+lh..h.........................................................................................................................	1	1038	2061	2768
+2746	PF00251	Glyco_hydro_32N	glycosyl_hydro2; Glyco_hydro_32; 	Glycosyl hydrolases family 32 N-terminal domain	Finn RD	anon	Prosite	Domain	This domain corresponds to the N-terminal domain of glycosyl hydrolase family 32 which forms a five bladed beta propeller structure [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.39	0.70	-5.06	138	4354	2012-10-02 00:26:57	2003-04-07 12:59:11	15	62	2280	59	842	3991	275	289.10	30	57.76	CHANGED	HFpP.psWhNDPNG.hY..apGhYHLFYQaNP.huss..W..G...htWGHus.ScDLlpWpcls.hAlhPs.p.aDtpG..saSGSAslhss..p..............lhhlYTGs...sp...........p...tpsQslAhsh.c.u....tpahK.....NPllh....Pss...sspcFRDPpshWhp....-.upWhhllGuppp.....ppGhshlYcS..pD..hhpW.phhsphhpss..t.....stMWECPDha.lss.p........................s.t.t.....hhhVLthS...............pssttshY.hlGp.as..psspa.ss...........s...hh....chDaGp..FYAupoFhD.....ssp.RRllhGWhu.psDtp.tsphs......cGWsu..hholPRplhL.........-..ttspLlQhP	........................................................................................................HhpP.t.s...h...hN....DPNG............hha...a.....pG.p.Y.Hl.F..Y..Q...........a..................P....h.....u.....sh....................a....G.............h...p.................W.....u..H.s....s.....S....c..D.....L..l..pW.......p..p..............h.....s.......h....A....l........h.......P...s.....p..........h.......D.....p...p.....G.............sa.SGS..Ah.........ss..p.......................................................................................lhh.hYTGpsp..............................................pt...pph...Q..s..l..Ahs....csu....................hpap.K.......................sPllht...........P.s.............tsp...cF........R......D...P........pl..............a...pt................s..sp..ah......h.l............l............G.....u.......p...........p......................p................p.........G............p..l....h....lY.p..S.....pD......l....h..p...W.p.h.h..u.t...h.h..t.sst............................uhMWE...C..PDha..lssp.........................................................................lLhhss....sht.........................pshht.s.hY...h..l..Gp....a..p.....pst..pa.sp...............................tp.ht.plD...hG.....h.-.....a.......Y.A......sp....oa.s................sss...Rpl.hhuWh....s...............-.............hs..........tpsW...t.u.sh.................olsRplpl.......ps.....spLhphP...............................................................................................................................................	0	225	502	696
+2747	PF01301	Glyco_hydro_35	Glycosyl_hydr17; 	Glycosyl hydrolases family 35	Finn RD, Bateman A	anon	Prosite	Family	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.19	0.70	-5.08	37	2284	2012-10-03 05:44:19	2003-04-07 12:59:11	14	47	1041	19	826	2224	59	273.10	34	43.63	CHANGED	shll-Gp.hhllSGulHYhRhs.PphWtDhlpKsKshGhNslpTYV.WNhHEPppGp.asFpGt.hDlscFl+hs.pctGLaVlLRsGPYICAEWshGGhPsWLhph..shphRoss.s.ahptscpahstlhshlts..LhhspG.GPIIhsQlENEYG......hss-tsYht.thschhhchsss.shhhssssPhhhshps....shss...lhssssasss...t.........h........ts.pPpp....PhhhsEaWsGWFspWGp.......hpcsspc..lAtsltchltps......u.hNhYMaHGGTNFGhhsGushhs..........TSYDYDAPlsEtGphs.sKYttl+clhpth	.............................................................................hhlsGp.hhlhSGtlHY.R...........hs....p.............W....c.....hl..ph.........K.shG......hNslpo..Y...l.........WN.......hHEP.p................Gp.....ap.F..........p..G...................hD......l.t..tFlph...A...pch.GL.a.l.l.l.R..............PGP..Y.........lC........A......EW....ph..G.G..h..P............s..WL.....h....p..............................s.......h.............p..........h.....R.................o........s...........s.................................s.............ah.....t....t...s....p...pa...........h...p........t........l........hs.h.hts..........h.h...s.........p.........G.....G.......s..ll.h.h.....Q.............lENE.YG.....................................s.-.....t..sYht....thtp.h.h.h.p.h.u...h......s..........s.....h.....hs..ss.....s....s..........hh.ps.............sh.t...........lhssssahst.....t.....................................................p......sp.t............Ph.........hh..........hE..has.G..........WastWut.................................sh....p.......p.s.s.pp........hs..s...ltch..lttt...................................s.hNhYM..................aaGG.T.N....F..G.hhsGsshh..............................TS......Y..................DYDAslsE.Gt.s.........Kahtl+phht..h........................................................................................................................................	0	254	472	661
+2748	PF01074	Glyco_hydro_38	Glycosyl_hydr16;	Glycosyl hydrolases family 38 N-terminal domain	Finn RD, Bateman A	anon	Pfam-B_731 (release 3.0)	Domain	Glycosyl hydrolases are key enzymes of carbohydrate metabolism.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.56	0.70	-5.15	50	2799	2012-10-03 16:37:10	2003-04-07 12:59:11	17	32	1483	64	926	2418	153	271.20	24	29.16	CHANGED	plasluHuHhDsuWLaslc-s.........pppspps..asol...lshhcc.s-hpF..htupsthaphhhcc.psphhpcl.+chVpcGphEhluGhWV.sDpshssh-ollcQhhhGp+ahccpFG..hpscsuWhsDsFGaSushPplhp.puGhctahhp+lsasspsph............ptpFhWcu.cu.........oclhoahhsh.............sh......ssph.............................cspsllpthpphtsptt......sspsLhshGhs.........Dsstsshcchlctlpthps.h.....hhsclphuTs.spYacslcp.........................ss-h.sas	..................................................lahlsHsHhDh..t.Whhshccp.......................chplhph.....hssl........ls.hh......c........p..p......P......-...........a.p....F.......htu.........p......s......................t...hh..c...a.h....p...........pP........c.t..........hp..cl...+......chl....p...p....G........+...lph.h...........Gshal.sDss.lsuuEuhlRphh..hGp..phh..pp.....paG.........tps......phuahPDsFG.a..suphPplhp.tsGhc..th........h....htR..h........s.....h..s...pt..sph................................p...pp.Fh...Wp.u.DG.......................ocl....hs.thhst........................hssth...........................................................phpt.h..h..p.t....h.p.ph....t.p...t.th.................s.s.p.h.lh.shGts.............................pt.t.hs.s.pp.ph..hch.hphh.pp...h..........................stsphhh.u.s..pcahptlctt.......................................................................................................................................................................................................................................................	0	336	545	754
+2749	PF01229	Glyco_hydro_39	Glycosyl_hydr19;	Glycosyl hydrolases family 39	Finn RD, Bateman A	anon	Prosite	Family	\N	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.63	0.70	-6.11	4	463	2012-10-03 05:44:19	2003-04-07 12:59:11	12	17	292	30	189	512	70	356.40	18	64.27	CHANGED	hthscsPclshsDutRshR.l..FWR...aC.....stus+hsLuhcpphphshhtshschGhE.lRhHhLL..DlhssRc.ssGpGLh..YNFTalDuhlDhLhE.tlhP....GF..hu.sSGphTsFc.K......+ph.cWp-LVphLAR+aIuRYGlscVpKWsFEsWNEPsh+DF.psuhppp.ahphYcssucul+tssssL+lGGP..........shChul.tahtshpNFhTtEs.V.lDaIShHppsuspuhhh.cp..tsltpscphhsEFt-s..lhp-EA.P.lsatlsp.......Yss.ss.hss.HpsP..hNuuhhhR..lLSpsssaLuh....FS.hThTshFp.sssp.......RpPhhsuhGLlALh...tl.t.s.+uhplLDu..tp...hlhtspHhsh...uspsshpsslllas....+shstpslPsp.hhlslP...shc.Valp..hlDp.pusPausW.+MGpPsaPotEQhcchRtsp-P.htcsspPhsssGcLTLchcLhhsSllLlclssR	...........................................................................................hh....................................................................................................................................................................................asa.t.lDthhDhh..h.t...thhP.....ua...................t.........s....s.....t.................t...................a.....................p....................................p.p..h.t.tW...t.pllpthsp+h.h...tR.Y...G..h.t....p....V.p.....p..W........aEl..WN.E.................Psh.....t............a...h...........................u........p...t.....p......a...h.p.hY...pt.ssc.sl+.t.s.....s.....P....t....h.p..l..G..GP................................................sh.s...h...s................t......a..h....phh..pa...h....ttp....t...h...........h.Da..loh.H.h.s.................................t......................................................................................................................................h.........................................................................................................hs...........................tt...........ss....h.........ht...................t..............h.....h.h....t.ht........................h....ss.......thhs.................th.t.s...h..htt.....tt.............t.t..................................t........h..hhh.t...............................................................................h.......................................................h......ss.....a.t..............s........t...h..h.....t...................................................................................................................................................................................................................................................................................	1	89	140	163
+2750	PF01915	Glyco_hydro_3_C	glycosyl_hydr14; 	Glycosyl hydrolase family 3 C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1151 (release 3.0)	Domain	This domain is involved in catalysis and may be involved in binding beta-glucan [1]. This domain is found associated with Pfam:PF00933.	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null --hand HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.56	0.70	-4.83	107	5906	2009-12-10 17:01:25	2003-04-07 12:59:11	17	121	2112	34	2239	5621	1277	251.70	26	33.08	CHANGED	hVLLKN-s.....tlLPLsppt..............+lAllGssAs......................................t....sh.t.......................................hsoslpulpptssssshhh...t..h............................................................................................................................................................................ssstthspAspsAppu....DssllhlG...........h...................................t....st.slpLs..tspppLlptl.ssss....tsslVVltsGsPlsh..hhp...............pssAllhuahPG........pcuGpAlA-lLaGc......sNPoG+LPhTaspsh.........sphPshh........................th...tt.sshhsau.cGL.hsh	................................................................................................................................................................................................................................................................hVLL.KN....cs.................thLP.Lptst............................plAVlG.s..As........................................................shh.h...su...ss.........ut..s.........st................................................hso..h.pu.lppt...h...s....p.s....s...h..h...h..h........h......h.............................................................................................................................................................................................................................................................................................sp.thhs..p...A..s..p...s.A.p.pu.........D..s..sll.slG..........tspt............................................................t..ts+...s.s..l...s.L..s.....t...s....Q..p...p..L..l.p.sl...t.sss............pss.........V...lV.l.h.sGpPls.l.t..h.tp................pssAlltsa.hsG...................p.p.u.G......pAl.A-l.La.G.c.................................hN.P...S......G......+...LPhoaPpsh..................................sphPsh.hs...............................................h.hpta...........st...t......sha.sFG...aGLSYo....................................................................................................................	0	741	1451	1968
+2751	PF02056	Glyco_hydro_4		Family 4 glycosyl hydrolase	Mian N, Bateman A	anon	IPR001088	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.86	0.71	-4.97	8	3002	2012-10-10 17:06:42	2003-04-07 12:59:11	11	5	1469	33	466	1859	496	179.70	40	41.67	CHANGED	KIshIGGGSohhschllu.lp+h-cLsspcltLhDlDt..cRL-tltphscphl-csussl+hptossh+-ALpDADFVhsplpVG....hhssRtlDE+IPh+aGlhu..t-TsGPGGIh+GLRoIPslh-Is+chE-hsPcAWhLNYoNPhuhlTcAhhRhhPthKslGlCchshGhpctlAchLsl	...............................................................KlshIGGGSoaTPcl...l.Ghlt...c......h......cc..Ls..l..p...clhLhDl-s...p+L..-hltt....l..sp...+.........h..l..c.......p........s.....u.....s..s.......h......c....l.p..t....T....h...D...p+cALp.D..ADFVhs.plR...V.....G...........ths...sRt...hDE+IPL+aGllG..QETsG..sG.G.lh+uL..RTIPslh-Isc-hcc.l.s.P.s.A.Whl.NaoNPuuhVTEAhh+..h..t..s.....t..K.hlGlC...sh.P.lGhtptlAchLt.l...............................	0	162	299	370
+2752	PF02449	Glyco_hydro_42		Beta-galactosidase	Mian N, Bateman A	anon	Pfam-B_2131 (release 5.4)	Family	This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyses the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.27	0.70	-5.34	28	1345	2012-10-03 05:44:19	2003-04-07 12:59:11	10	34	760	3	435	3006	388	314.10	25	47.10	CHANGED	DY.PEQWsc..-hap-Dh+hM+cAGlshVslGhFuWutlEPpEGpa-FuW.......LDcll-hLtctGlpllLuTP........TAusPtWlsccaPElL.l-tcGphptaGuRppaChoSPsY.RptstcIsctL.....AERYus+PullsWHlsNEYGs....tCYC-pCtpAF...............RpWLcp+Y.........ss.l-pLNcAWGTsFWSppYssa--I.sPp.ts.........phhsPuptLDapRFsoDplhsahct.ctchl+choPchPlTTNFMs........hpshDaachApclDhlSWDsYPs...........stcp......pssthuhtpDLhRul..tpGpPFhl.MEpsPS.sVNW.pshN.t+tPGhhcLhShpulAHGA-sVhaFpW..RpuptusEpaHuullsHsu.sso+sapEVsclGccLcpl	..................................................................................................................................................................Y.P-.ph...........t...phhtcDhthhp.ps.shshsp.lu.F..u....Wstl.E......P....p....c....G...p...a.....c.....F.s.a..............LD......c...h....l...c....h...h...t..........p..t..G..lp...l...h....L.......u....T...s......................o..u.s.............P.t.....Wh...h.......p........p.......a...P.........-...h...h.......h...s................p..........G.t.......h...............h....................h.........G.......s...R..........p....p........h........s....h....s.s..s.sa....+c...hs......t....pls.ptl......................A.c..+....Y.....s....p...c...P.....s...l.hhW.p............l......s.....NE..hus....................sas...p..t...s..t..ttF.....................................ppW..Lc..p+.Y.........ts....lc.tLNpA..W...s.......ss.....a.....W..u......p.......ph..psa...pp......l.........Pt.....hs.............................t.....s.h.......l...Da..pRF.spth.hphhp..phphl+....th.s.s......p.h.......lT....p.N.hh.......................sh-h.h..p.h.u..p.t..h..Dh....h..u..h..D..tY........................t...........................uh....tsh..hRsh............ttp.s..ahl.hE.......p.ps..u....t.h...t.........h........s............s.G........h.h.h.shtt.hAtGup.l....aapa..+p......u.Ephatuhl..st...s.hht-h.thst.ht..h...................................................................................................................................................................................................	2	150	293	365
+2753	PF04616	Glyco_hydro_43		Glycosyl hydrolases family 43	Bateman A, Finn RD	anon	Pfam-B_5336 (release 7.5)	Family	The glycosyl hydrolase family 43 contains members that are arabinanase.  Rabinanases hydrolyses the alpha-1,5-linked  L-arabinofuranoside backbone of plant cell wall arabinans.  The structure of arabinanase Arb43A from Cellvibrio japonicus reveals a five-bladed beta-propeller fold. A long V-shaped  groove, partially enclosed at one end, forms a single extended  substrate-binding surface across the face of the propeller [1].	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.00	0.70	-5.32	37	5170	2012-10-02 00:26:57	2003-04-07 12:59:11	9	188	1022	90	1859	5327	430	265.80	18	57.35	CHANGED	hpNPllpGhhPDPolhRsscs...YYlssooFtha......PGl.la+S+DLssWp.lupslsptsphsh..tsss..........WAPslp....atsG+aalhao...............ps......sallsucssc...GPWo-shhl.........sstulDPolFhDss...GcpYLhhsths.t..............tIhhtchsssttphsups.phlhsus............shhhsEGP+la++sGa..YYLhsu....pGGTshs....ashsh...uRS+slhG.Paphpsssshlppt.....ssppslpssGHuullposcGc.aahsahstcs..............tshpshGRcThlp.lpWp.DGWP	......................................................................................................h...s...DPt...lh...t...h.........sst......a..Y..h.h....s......o....s.............................................t..h..........lh..p..S...p..D..L.........h......s..W...p........h..s.................s...h............s.........h............t............s.....t............t....h......t.tt.t............................W.....A...P.p...l.h.......................h..t..s..G.....c.....a..a.laas.....................t....t.ttt...................................hh.l.h.....p...u.....s...s..sp..........G.s.a...p...p....hth.......................................sttslD......s...sla.h.......D.c.....s........G.......p.h..Y....h.h......a.u.s.......t...................................t.l...h.....h....s..c..l......s.....s..s...h....h...p....h.....t...s..th..........t...h.hhtst........................................h.h...E...u.P....t..l....h...+......p...s......G..h.......Y.Y..l..hh.u.....................ts.s.s.t.s...........athsh...............................spu..p..s......h.G......Pa...........p..............t....t......hh..................................t.tt..h.........s.s......u.H.s.s..h..h...p...............p...u.....p..........h.h.h.ahsht........................................t...R...h.h..lt....h.ap...ss...................................................................................................................................	0	663	1303	1655
+2754	PF02015	Glyco_hydro_45		Glycosyl hydrolase family 45	Bateman A	anon	SwissProt	Domain	\N	20.30	20.30	21.70	20.80	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.30	0.71	-4.25	6	228	2012-10-01 21:39:58	2003-04-07 12:59:11	11	13	86	7	88	232	2	179.70	43	69.24	CHANGED	sGpoTRYWDCCKPSCuWsu..KuPs.tPV.oCstsssslss....ssspSGCp.GGuuYhCosppPa..sVsssLAaGFAAsohsGusEsshCCACYtLTFTs....GsltGK+hlVQuTNTGGDLGsspFDhshPGGGVGIFs.GCssQaG...uhhGsQYGGlpStpECsphP-sLpsGCcWRF.-WhcNsssP.hSFcpVpCPupllucSGCp	.......................................GhTTRYWDCCKsSCuWss..............K...A.ss....s.p...P...lpoCsts.s.ps.hss.............ssspSGCs...G...GsuYhCssppPW......uVN..ss....hu.YGFA...Ass...h.....s.....G.s...EsshCCsCapLTFTu..................uslsGKcMlVQsTNTGuD..L.....G.......s....N.....p.FDlthPGGG.VGhas.GCs..p...Q.a.u..s.s.st...aGpp..YG.Gl............s.o.........tspCsp......hP.....t..tLpsGCpaRF..sahtss....sNPshsFppVpCPtplsshosC.................................................................	1	41	60	80
+2755	PF01374	Glyco_hydro_46	Glycosyl_hydr23; 	Glycosyl hydrolase family 46	Bateman A	anon	SCOP	Domain	This family are chitosanase enzymes.	20.80	20.80	25.50	24.80	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.33	0.70	-4.79	7	127	2012-10-03 00:09:25	2003-04-07 12:59:11	13	7	97	4	42	129	4	207.80	39	69.76	CHANGED	hpLluhsENuohpWhppYsYsEclcDGRGYTsGIhGhsoG.TGDhL.llt.hpchsPsshLsKalPuh++stt.....hcppuslhshhsp-p.WpotspDh.hc.A.scstDcoaas.sAhppscssh....poALspushhDsslpHGsssss-SFtullKRstp+sp.......DEtpahpsFhssRhtsLhsstsc.spscssp..sRshhhsslhcpsNhsLK	......................................................................................hpLlSpsENSolcWctQ......YuYlEDls..DGRGY.TsGIhGFsoG....TGDhLplV.EhYspt...pP.sN.s.LupYLPALRclsu.......s-sp....sulssh.......hsts.....W.p..psA.p....D.tFctAQcctpD+lYas.PAhppucpsG....hssLuphsaYDshl.HGs..u..ss....s....s.....o..Ftulpc+uhpcAp..P.t........GsDEpsaLsuFLDsRh.sht...p..c..ts.cp.-sochcp..AphshlpphshphpssL..................................	0	18	32	40
+2756	PF02011	Glyco_hydro_48		Glycosyl hydrolase family 48	Bateman A	anon	SwissProt	Family	Members of this family are endoglucanase EC:3.2.1.4 and exoglucanase EC:3.2.1.91 enzymes that cleave cellulose or related substrate.	25.00	25.00	40.60	40.50	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	619	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.33	0.70	-13.25	0.70	-6.39	7	213	2012-10-03 02:33:51	2003-04-07 12:59:11	10	23	126	21	57	214	0	485.10	49	70.58	CHANGED	YtpRFhphYsKI+DPuNGYFSsc.GIPYHuVETLhVEAPDYGH.TTSEAaSYYlWLEAhYG+lTGDaStFppAW-shEcYhIPsppDQPst.MSsYsPNKPATYAsEapcPShYPS.Lchs.ssVGpDPltsELhSsYGos.lYGMHWLhDVDNWYGFGtpsst.......sopsoaINTFQRGsQESsWETlPQPsh-EaKaGGpNGFLDLFTtDs.sYAKQaKYTNAPDADARAlQAsYWAs.WAKEQGK..slSuhVuKAuKMGDYLRYuhFDKYF+KlG..s..pspAu.TGYDuAHYLLSWYYAWGGulsu..sWuW+IGsSHsHFGYQNPhAAWsLusDu-hKPKSsNGtsDWApSLcRQlEFYpWLQSAEGuIAGGATNSWsGRYpphPAGTsTFYGMuYs.pPVYtDPGSNpWFGhQAWSMQRVAEYYYtoGDspAKpLLDKWVcWlhuplplssDG.TFpIPSsLcWoGQPDTW..suoYTGNsNLHVcVssYGsDLGlAuSLANALhYYAstotc......ppA+shAKc....LLDthWt..YpDs.KGlussEsRuDY+RF.-p......pVYlPuGWoGpMPNGDsIcsGlpFlDIRSKY+pDPsWsplpsAhpsGpsPshpYHRFWAQsDlAlA.GsYuhLF	..............................tcFht.atpl...ps....t....sGYas..p........G......lPYH..SlETLhl.EAPDaGH.TTSEAaSYhlWLEAhYG+lTG....D........W.o.....h.....hpsAWcshEpYhIP.....s.p.....p-....QPs...stY....ss.spPATYAsEh.ppPspYPu....lphs.sssGpDPltsELtSsYGost....hYtMHWLhDVDNhYGaGpt.st.......sotsoaINTaQRG.pESsWETlPpPoh-pF+aG....t.....N..GaLsLFst.-s...s..........u+QW+YTsAsDADARAlQAsYWA..WApppGp....plushhsKAuKMGDaLRYshaDKYFpplG...sts.p..s.s.su.sGh-SsHYLhuWYhuWGGuhss.....sWuW+IGsSHsH.GYQNPhAAaALus......s.shtP..KSssutpDWtpSLcRQlEhYpWLQSuEGAIAGGuTNSWpGpYtp.Pu..G..s..s..TFYGMhYs.tPVYtDPsSNpWFGhQsWshpRlhphY.....................p..G............s............tt......s..........t...........tlhc+Wh.Whht.h.ht....t.s...pa....hPupLpW.......sGt...P........................sss..lpsps.s.s.p.DlGhhuuhspsL.aauststt..........................................ttutthAptLLDthat...pst.hGlss.E...ttsY.Ra.p........tlYlP.tsas.Gp.spGs.l...........psu..................pF.slRshhppDs.a..l.thht......s......u..................P......hpaHRFWtps-hAhA.u.ht.h............................	0	22	43	49
+2757	PF03718	Glyco_hydro_49		Glycosyl hydrolase family 49	Finn RD	anon	Pfam-B_8840	Family	Family of dextranase (EC 3.2.1.11) and isopullulanase (EC 3.2.1.57). Dextranase hydrolyses alpha-1,6-glycosidic bonds in dextran polymers.	21.30	21.30	21.90	22.60	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.97	0.70	-6.44	4	30	2012-10-02 14:50:22	2003-04-07 12:59:11	8	4	25	8	8	54	0	496.90	33	80.09	CHANGED	sus.psAhpstpsssTsssupLpTWWHssGEhNspTPsQsGNVRpSuhYsVQVupAsssps.hYDSFsYhSIPRsGpG+I............s.o..DGhpaosuhsLoMuWSSFEYS+DVhVclphpsGpolsSsspVsIRPoShsFthphsDssoVhI+VPYSssGYRFSVEF-spLaThhsD..Gst......suGs.psltsEPcNuhhIFApPhL.ut.tpphlPp.sSsshphPpPG.VpNLsosocpllYFpPGsYaMsscp..........HhsLsuNVpWVYLAPGAYVKGAhcFh.sTpupaKsTG+GVLSGEQYVYpADsssuYh.hSsAspscsosl+MhpassusutQp.hslpGlTlutPPapShsh.GNp....hphpV-sYKQVGuaYaQTDGhElY.GohhpssFaHsNDDsLKhYaSsVTlcNsVIWKscNuPVIQaGWTPRNI-NVslsNssVIHsRhhhp-shhNosIhsuSsaY....tshuSs.oouDospTlpNhphpNhssEGhosshhRIhsLpNh-NIpIKNlsIsuasGLp...hsop.Sal.taoshsstK........sspGlslENaTVGGppI..TssN.psspLGRls.hDsp.WssWphh	...........................................................................................................................................s.................hsssthpTWWHssu.hs.t.tshtsspVRpSphYpVpVt.As...t.pp.hacSFsY.SIPRsGpG+................s.o.tDGh.phpsphshsMuWopFpYspDl.lcl..psGpslsssspVsIRPsshsathp.ssstslh.I+VPhp.sGh+FSVEFpsplhohhss...Gpp....h.spGs..hlt.EPpNuhhIFApPhl.st....hlPp.pss...........s.s.hhpsG.lsshs.socsllYFtPGlYahs..pct..........+hpLssNspaVYlAPG.AYVKGAh...cah..tsppsapssG+GVLSGEpYVY..pAssspsY...h.........Aspscppsl+Mhhapsssu.sQp.hphtGsTlssPPapohslhu......spt........hpsplssYKQVGuaaaQTDGhplY.psS..h..l..+..csFaHsNDDsl.....KhY......a....S...s.........sslcsssIWKscNsP.l.I...QhG.....Ws...s..Rs.....Is.sVslcslslIHs....RhhhspshhsosIhsuSsaa.......uss.hpsDsppph.shphpNhssEGhss.sh..h+lhsLpN..hcthhlcNhth....s.sht......hsht.sh..h.thps...............shGl.lpNaolGsppl..shpNhtttphGphs.hcst.hspWph.t...............................................................................................	1	3	4	8
+2758	PF03512	Glyco_hydro_52		Glycosyl hydrolase family 52	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	276.40	276.00	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.30	0.70	-5.88	4	35	2010-01-08 16:07:30	2003-04-07 12:59:11	8	1	33	0	14	36	16	418.20	50	59.32	CHANGED	FTLGaPGpuGGLDLELG+PPcQNVYIGLpS.c-ttpYcsLPFatsu.pDEusRYDlEpsDss.......pQcPp.llhPFs+-EIhR-FsuuTDTWpAGDLTFpIYSPVcuVPDPpsAsEEEL+hALVPAVLsEhTIDNTcGppsR+AFFGapGsDPYSuMR+I-Dsss.plsGVGQGRlTuIsSsDculpsAlaFohEDlLspthcENhsFGLGpsuALlhDVPAGEK+TYpFAVCFYRGGlVTsGhDsoYaYTRaFpsIEEVGEYALtQFstlttputcu-pLlssutLS-DQpFMhAHAIRSYYGsTQLLEH-G+PLWVVNEGEYRMMNTFDLTVDQLFFELKhNPWTVKN.LDLaVcRYSYcDcVRFPG--TEYPGGISFTHDMGVANoFSRPsYSSYELaGIDsCFSHMTHEQLVNWlLCAoVYl	..FTLGahGpsGGLsLELu+PscpNVYIGhco.cpsuhYchLPFacss.p-Euc.RYshEps-ss........p+ss.hlhsFucccIpREapsATDTWpAGDLT..FplhSPhcsVPDPts..As--EL+hALsPAVhsElTlDNTpGopsR+uFFGapGsDPYouhRhl.........s-.........ss....s.....pLpGlGQGRphuI.s.o.p.-.csVcsuhtFuhEclLssphpcNh.sFGLGpsGALlh-VPAGEK+TYpFAlCFYRuGhVTsGh-sSYYYTRaFcsIE-VupYAL-phsthtstutptschlc.pu.tLS-DQ+FMlAHAI+SYYGSTQL.L..-.....c.........-Gc.PlWVVNEGEYRMMNTFDLTVDQLFaEL+hNPWTV+NsLDhaVcRYSYcDpV+FPG-.-pp......YPGGISFTHDMGVANsFSRPsYSuYELsGls.uCFSaMTHEQLVNWlLCAsVYl.	0	4	8	10
+2759	PF01630	Glyco_hydro_56		Hyaluronidase	Bateman A	anon	Pfam-B_1150 (release 4.1)	Domain	\N	18.70	18.70	19.80	19.40	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.04	0.70	-5.80	11	533	2012-10-03 05:44:19	2003-04-07 12:59:11	13	6	152	6	235	478	2	274.00	38	74.85	CHANGED	hRuP.llsspsFlhsWNsPTphChtchshslDlSh.FullusPpcshpGQslTIFYs-cLGhYPalssps....pthpGGlPQpusLppHLs+spp-IpphlPs.DhsGLAVIDWEcWRPpWtpNWpsKDlY+ppSl-LVQspHPphshscsptcApppFEcAA+tFMp-TL+LGKhLRPptLWGaYhFPDCYN.hcapsss..YsGpC.ssphpRNDpLuWLWppSoALaPSlYLpppLpusp+s.t.h.VRtRVpEAlRVu+lscsspslPVhsYsR.lFpDpsspaLoc-DLlpTlGE.sALGuuGlllWGohuhspotpsC.tL+pYhpopLsPYllNVThAAp	....................................h.....h.tpPFhhhWNsPop.Ch..+ath.l....s........l.ph..Fslhssstpp.h.t.G.p........slTIFYtspLGhYPahs.ps.............hshpGGlPQpss.LptH.Lpphtpcltt.....hlss.p.tGLuVIDW.............Et....WRPhWtpN.Wt.s.KclY+ptS......htllpp..p.....psp....h.s.......p..p.ltt.AptpFEtuA+taM.pTLpLupthRPptLWGaYhaPcCa..N.ashh..p..s..s....YoG..pCsshthtcN.-pL.tWLWtpSsAL.aPSlYl..tltss...ps.....Vp.RlpEAhRluthh.p.t............hPVhsY..s+..h.....h...p..t..............s..p.......h....Lop...tDLhpTlGEosAhG..uuGlllWGs..p..sp...o.....p..pC.tlppYlpp.Ls.alhNVo.us........................	2	43	64	130
+2760	PF03065	Glyco_hydro_57		Glycosyl hydrolase family 57	Bateman A, Moxon SJ	anon	Pfam-B_2506 (release 6.4)	Family	This family includes alpha-amylase (EC:3.2.1.1), 4--glucanotransferase (EC:2.4.1.-) and amylopullulanase enzymes.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.98	0.70	-5.54	22	1145	2012-10-03 16:37:10	2003-04-07 12:59:11	10	25	737	10	560	1481	541	339.30	17	56.79	CHANGED	sFhhHpp..hh.p................................uspsYl..........shhphlhch.p........h+hshsloGshlEQlpchtsph...............................................................................................................................................................lpha+p...LhcsGp..lEllsssaaHslhsllsc.....................p-hhpQlchtcchhcchFG...hcPpuhassEhsass................clhchltchGhchlhs-stth..............hhsspsst.hah.......tspt...lslhhRshpLScpIuFpa.......usccah.................pa.h....hh.hhstspspllhlhhDhEsa.....staphtppshh-hhhth..phppp.................shlphhtsp..Ehhpchtscshlhhs.tt.....................................hsWh...........ctshstWlus.tppthhptl	...............................................................................................................................................................................................................................................................................................................h.hH.p...hh......................................t.........................ht.psYh................shhthh.ph.p..........hph.shshosslhp.lpp.h.t............................................................................................................................................................................................................................................................................................................................................................ls.h.h+p.........L.c....p..Gp...lElls...ssasH.s.....l.h..P.Lhsp.......................csh.ptpl.....phuhpt..h..cc..h..F..G....ppP.c.G.hWhs...E.tu.ass........................................................sl..hphl.sp.t.G...h..c..a.h..h...s-stth............................................hhs.ht...s..s.p...ha.t..................sspt............................ltlh.hRDhplS.p.plh..ph..........................shccah..................................................................ph.h..............hh..t..........t............s..th.h.....hh..hchc..th...........tht.....tp.hht...hh.....t.....t...ptt.....................................t.....l..t..h..hp.p.....ch.h..p.....t.h......................h.................................................................pWh.................................................h..........................................................................................................................................................................................................	1	229	411	492
+2761	PF02057	Glyco_hydro_59		Glycosyl hydrolase family 59	Mian N, Bateman A	anon	IPR001286	Family	\N	27.00	27.00	27.20	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	669	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-13.24	0.70	-6.46	3	168	2012-10-03 05:44:19	2003-04-07 12:59:11	10	10	93	2	88	169	18	493.00	37	83.35	CHANGED	MTAAAGSAGRAAVPLLLCALLVPGGAYVLDDSDGLGREFDGIGAVSGGGATSRLLVNYPEPYRSQILDYLFKPNFGASLHILKVEIGGDGQTTDGTEPSHMHYALDENYFRGYEWWLMKEAKKRNPNIILMGLPWSFPGWLGKGFsWPYVNLQLTAYYVVTWIVGAKHYHDLDIDYIGIWNERSFDANYIKlLRKMLNYQGLQRVKIIASDNLWEPISASMLLDuELaKVVDVIGAHYPGTHTVKDAKLTGKKLWSSEDFSTLNSDVGAGCWGRILNQNYINGYMTSTIAWNLVASYYEQLPYGRCGLMTAQEPWSGHYVVESPIWVSAHTTQFTQPGWYYLKTVGHLEKGGSYVALTDGLGNLTIIIETMSHKHStCIRPFLPYFNVS+QFATFVLKGSFSEIPELQVWYTKLGKPSERaLFKQLDSLWLLDSSGSFTLELcEDEIFTLTTLTTGRKGSYPLPPKScPFPosYKDDFNVDYPFFSEAPNFADQTGVFEYFTNIEDPGEHRFTLRQVLNQRPITWAADASNTISIIGDY+WTNLTV+CDVYIETP-oGGVFIAGRVNKGGILIRSARGIFFWIFANGSYRVTGDLAGWIIYALGRVDVTAKKWYTLTLsIKG+FASGMLNGKoLWKNIPVsFPKNGWAAIGTHSFEFAQFDNF+VEATR	......................................................................................FcGhGslS.ususs.SRLLhsY........c..s.......hs...pILcaLF.tss.aGAulph...LKVEhG..u..........D....spoo.....s.....Go....EPSp......+h.t..-.t.......N.....h...R..GYp...ahLht-AKphNPsIplhsLsWuhPGW..l...s......p.....u...............s.........h................p.....hss...........Y.h.h.pW....l..............uu.tphasLslDYl.u..h.h.....NE+.s..a...s.h.p......a.l.K............h....LR.p.hL....................s..........tp......G..........hppl+IlAuD......sh...a...t...s...lu..ts.hh.DspLhpsl.sllGs..H..Y.....s.....s....s...........ss....t........p........u........s...t...KplW.sSE.....shS.......s..h.......s...........p......h......G.u..........us........h.u......Rh........L...N...ps......Yl.su.....hT....uhIsWs...........lluuaY.tlsaspp.uLhs..AppPWSGtY.lps.slWl...AHhT.QFspsGW.hY.L...p...s....s..Gth....pt...........s.GSa..Vu.Lss.s.h.s.......s.h.ohllE.....Th.s.....tp.t.s...h...........t...s..p.hp..h.l...psth..t.t......tlpVW.op...h...s.t....s..p.t........a.phtsh.......s.tG..taolp..lt.splhTlTTh..sst.t+..u.sh.s..ss.....st....hs...............Yp-s..Fs...t.........hs...t..........s..h.s.D.tGsFEhh.s........tt...thhsh+Qh...sptslsWts.......s..hshlGs.pW.s.htlp.Dhhh-............t...h.l.hths..ts......tt..........sh.....h.h.l...ts.Gtat..l...........t.t..........................h..t........h.....t..Whpltl..h.t.....s.......st..h......................G.hshhs..h...spaDsh.l....t......................................................................................................................................................................................................................................	0	35	48	63
+2762	PF01341	Glyco_hydro_6	Glycosyl_hydr21; 	Glycosyl hydrolases family 6	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	17.70	17.70	17.70	17.70	17.20	16.60	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.16	0.70	-4.98	74	628	2010-01-08 14:25:27	2003-04-07 12:59:11	12	33	332	44	282	614	35	289.60	31	63.55	CHANGED	sNPhas.uphtstst..t.....ushssttpplA.phPouhWl.sphstsss...........ltstLsshhupttsusp...sshhVlYslPsRDCsAhASsG....ussuhspY+s.YIDsIsstl...................tassh+sllllEPDoLuNhlTs......ssspC....t.ss..pstahpslsYA.lppLtshs.NVthYlD........AGHuuWLG..ss...uAplhuphhpsAGss...plRGhuoNVuNYssh.............................hDEhsYtp.................slsstLsstGh.ssc...................................................FllDTuRNGhss.........................p.thGsWC..NssGs.GhGtpPosss...usshlDAalWlKssGESDGs.......ssssustaDt	............................................t.h....s...........t.....ss.ssthppl.u.shPsuhWl..sph...s.ss...........ltstlsshh.ststssst...hshlVlYslPsRDC...u.ht.S.s.G..........ussshspY+s..aIDslAshl.......................us..hpsllll.....EPDuLsph..................hspC...........t.ss...pst..hhp.tlpYA.lppL.t.shs.sstsYlDAGH.uuWL..............uAph.huphlpssGss........ps+GFusNVuNapsh.........................................-EhsYsp..................s.lsshl.st.th..ssp..........................................................allDTSR.NGhus.............................t..usW..C.........NssGtulGt.Posss....ssshlDAalWlKsPGESDGss....ssttu.h...t.........................................................................	1	93	195	260
+2763	PF03443	Glyco_hydro_61		Glycosyl hydrolase family 61	Bateman A, Eberhardt R	anon	CAZY	Family	Although weak endoglucanase activity has been demonstrated in several members of this family [1-3], they lack the clustered conserved catalytic acidic amino acids present in most glycoside hydrolases. Many members of this family lack measurable cellulase activity on their own, but enhance the activity of other cellulolytic enzymes. They are therefore unlikely to be true glycoside hydrolases [4].	27.00	27.00	27.50	27.70	26.30	25.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.53	0.70	-4.52	55	827	2010-01-08 16:05:35	2003-04-07 12:59:11	9	12	88	14	728	841	1	202.70	30	69.52	CHANGED	HuhVsslhl..sGspYsuapssth.hts.........s.st..ssssG.l..sshsSsDIh..................Cpp.......su..ssussps.sVsAGsplshp.Ws...............aspSH...+GPl......lsYLApC..sss.Csoss..pouhpaFKIspsG...hssuops..........Wus..........DpLI.sssssaslpIPsslusGpYlLRHElIALHuAu........sts........GAQ.YPpChplpVTGuGoss............Pu.G...VshsuhYpsTDPGIhh..sIYps.s......s.Ysl	........................................................................Hhhhtthhl..sG....tth.......................................ssusl........ps...h.s.os-lt......................Cst.................su.....ss..u..s...s..p.s.....sVtAG.spl.shphs...................................hs...s....H....G.Pl...................hsYhucs.....sss...ssshs....ssuhtWFKItptG..............hss..ss.t.................Wu.s....................t..h.....t.....s.....s..s...p...hshp........IPpslssGpY...LlR.tEh...IA.......LHsAt........p....s..........GAQaY...pCsQlpV.o.G.u.Gsss.............Pu...s................Vp.h.P.G........hYp.s.sD.P.G.lh..h......slYts.......sY.......................	0	249	456	651
+2764	PF03664	Glyco_hydro_62		Glycosyl hydrolase family 62 	Finn RD	anon	CAZY 	Family	Family of alpha -L-arabinofuranosidase (EC 3.2.1.55).  This enzyme hydrolysed aryl alpha-L-arabinofuranosides and  cleaves arabinosyl side chains from arabinoxylan and arabinan. 	20.20	20.20	20.90	20.40	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.99	0.70	-5.27	5	187	2012-10-02 00:26:57	2003-04-07 12:59:11	8	20	99	0	116	198	2	263.70	55	59.08	CHANGED	CALPSoY+WTSTGALApPKu.GWAuLKDFTsVsaNGKHIVYASsaDTuosYGSMuFGPFoDWS-MASASQTAMSto....AVAPTLFYFAPKNIWVLAYQWGuooFSYRTSSDPTNPNGWSAsQsLFoGpI..SGSuTGAIDQTVIGDDTNMYLFFAGDNGKIYRSSMPIuNFPGSFGopYolIMSDoTsN....LFEAVQVYTVDG...QN+YLMIVEAhGSuG.RYFRSFTAoSLsGsWTPQAATESNPFAGKANSGATWTsDISHGDLVRNNPDQTMTVDPCN	...............CsLPSoY+WoS.T..GsLAp..PKs....G..W..suLKDFTsVsYNGpaLVYAost....s....u.u...s...aG.SMsFusFosWSphuSAsQs.....thspu.......sVAPoLFYFAPKslWlLsYQ.WG.s.s.sFuY+TSoDPoNPNGWSusQsLF.o...G...o...I.....ssu..ssG...s...ID.sl.IuDspNMYLFFAG..DN..G.+IYRuoMPluNFPGuF.Gossssl.hSD.o..p.sN....LFEAspV...Y+lpG...ps..p..YLMIVEAIG..u..sG.....RYFRSF.TAoSLsGsWTPpA..uoE..o.NPFAG.....KAN....S....G.....A....o.WTsDISHG-LlRs.ssDQThTlDPCN...............................................................................	0	30	74	107
+2765	PF03633	Glyco_hydro_65C	Glyco_hydro_65c; 	Glycosyl hydrolase family 65, C-terminal domain 	Finn RD	anon	Pfam-B_3470 (release 7.0)	Family	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP)  is a dimeric enzyme that catalyses the conversion of maltose and  inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  The C-terminal domain forms a two layered jelly roll motif.  This domain is situated at the base of the catalytic domain, however its function remains unknown [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.48	0.72	-3.88	18	1485	2010-01-08 16:08:30	2003-04-07 12:59:11	10	16	1123	2	318	1157	33	52.00	27	6.46	CHANGED	PhLPctast.luF+.lhaRGph.lplplsppplplplhpGp..sLslclhGcclsLcs	......PtLPcpWpp..luFp.lha+Gph.LpVpls..p..p.p..lslph...pu............sl.slpl.Gp.hpl..s.....................	0	86	198	275
+2766	PF03632	Glyco_hydro_65m		Glycosyl hydrolase family 65 central catalytic domain	Finn RD	anon	Pfam-B_3470 (release 7.0)	Family	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. The central domain is the catalytic domain, which binds a phosphate ion that is proximal the the highly conserved Glu.  The arrangement of the phosphate and the glutamate is thought to cause nucleophilic attack on the anomeric carbon atom [1].  The catalytic domain also forms the majority of the dimerisation interface.	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.27	0.70	-5.78	16	1977	2012-10-03 02:33:51	2003-04-07 12:59:11	10	29	1435	2	510	1594	109	362.80	34	46.01	CHANGED	Rhsl......FaLhpshss.......p-....scLs...........lus+GLoG-u.....YtGtsFWDTEhaslPhhl.hstPclA+sLLpYRhppLsuA+..........csA+phGhp.GAhaPWpoup...GpEso..........s.cht..ss.ppphHlsusIAaA.lhpYhpsTG..DppahpcpGh-lll-sA+FWsu+schspp.stapIcsVsGPDEYc........sslssNsYTNhhAtasLphAhchhcphspt..........htlppp-hcpWc-l...ucphalPhccp.GV.......h.Qa-Gahcht.hshtt...h..t.h...h..chthspl.ptphlKQADllhhhYh............htttastcphtpN....h-aYts+Ts+-S.oLSsslaullAAchsch...spAh-aa.pcusc.................lDl.cs.sss.Tp-Gl.HlsuhuGshpsllpGFuGh...+hc..........sspL	.......................................................RaslapLhtshss........p-.......tchs.............Iu..sKGL....T....GEu.......YtGHsFWDT.E.ha.hlPhal.hsp..P.p.lA+.s.LLpY..RappL.stA.p................cpA.......p.......p...............G.......h..........p..G..AhaPWpoh..p....G...p...Eso.............s.pht...hu..ttphHlsusIAaA.lhp.Yh.psTG..D....psal.t.c.p.....G.h.c.lLlEsA+FWss....t.s.p....h....s.....p....t..............s..c..apI.cs.VhGPDEYp...........ssVsNN.s.YTNhhAtasl...ph...Ah....phhpp..hspp.................thth.s..p.t......-htp..W.pch.........scphhlP.h...s......p......p........Gl........hsQpDuFhsht..h.s.hsp.....h.spph......l..c.h.ph..tpl.chphlKQADVlhhhYh..............hs.cpF..ot..p.p.ttpN....hcaYEs.hT..s..H..-..S...SLShslaullAA.cl.Gh.......pp.Ahpha.pcusp......................lDL....s....s..s.....p.s.....sp.....-.....G..l..H.h.....suhuGsWhulltGFuGh...csp.pst.......................................	0	155	305	432
+2767	PF03636	Glyco_hydro_65N	Glyco_hydro_65n; 	Glycosyl hydrolase family 65, N-terminal domain 	Finn RD	anon	Pfam-B_3470 (release 7.0)	Family	This family of glycosyl hydrolases contains vacuolar acid trehalase and maltose phosphorylase.Maltose phosphorylase (MP)  is a dimeric enzyme that catalyses the conversion of maltose and  inorganic phosphate into beta-D-glucose-1-phosphate and glucose.  This domain is believed to be essential for catalytic activity [1] although its precise function remains unknown.	18.80	18.80	18.80	18.90	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.62	0.70	-5.07	14	1768	2012-10-02 23:57:29	2003-04-07 12:59:11	10	18	1343	2	416	1391	80	251.00	25	31.06	CHANGED	plppsphshpp.p+h.pESlhulGNGYhGhR........Gs.....h-Eshss...............ph.GoY..luGla............phsp..........lu....Ghsp.hpcllN.hsNahtlcl.hlsGcs.hDlst...sclpsappsLDh+pGlLpRphphp..s.ps.lclpscRFlShspppLuulchplp......sl-sps.clpltshlDusVsNcs...p...thhphhsp........chpsss.shlhscT..hsss......htsshsspphs.tsspt.h...sphp.sppcphlspphpsplp.spphplp.KhVslso.ScDh	...................................................l.ppphs.cp...hph..tESLhulGNGYlGhR.................Gs......hEEs.h.s..t............................................................................ph.tGsY...luG...la...................p..t.tp...................hu.........Gh..sc.....hpc.llN...sPshhshcl...tl....s.......s...-.......hsLsp........splpsapppLDh+p..............GhLpRphhaps.s...s.....G............pt...lplsscRFlShsphplsslc.hplp.................slss...s.s....plplpotl.......D...u..s.pNps.......................................hhptlsp...................p.s...t.spp....hhlh..hpT....ppss..............h..s.lsh.....uss.p..........h......t...s.........s.p....................t..............h.p.t.p....p......p.tltpp....hp.spl.p.tGps.h.slp.KhVhlts..Sc-................................................................................................	2	125	264	361
+2768	PF02435	Glyco_hydro_68		Levansucrase/Invertase	Mian N, Bateman A	anon	Pfam-B_2011 (release 5.4)	Family	This Pfam family consists of the glycosyl hydrolase 68 family, including several bacterial levansucrase enzymes, and invertase from zymomonas.	19.90	19.90	19.90	21.30	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.46	0.70	-5.77	11	358	2012-10-02 00:26:57	2003-04-07 12:59:11	11	10	223	29	68	411	121	335.70	36	80.16	CHANGED	hps.s....sophTRADhLKlspp.p.ss...........Th.sIsushsl.ss.....-l.VWDoWPLp-hc.GsVssasGapllFuLsuD.p.....................Rpscs+IthaYp+sGc.........sWhhuG+lht-uss.........spopEWSGoshlss..cGslcLFYTs..h........sssu..pulsstshshhhsD-psVplcGhpps+sLF.p.uDGhhYQshtQs.h.................asFRDPHsh.D..pcG+pYhlFEuNsusEc.........spsshGts-hhsls..ssh.ss.....ssApassGuIGIsphpDspt..o.hclhsPLlTussVsDpsERPpVlh.sGKaYLFThS+tsphu........DGlsGsDsVhhhhusstLpGPYcPlN.uSGLVLsss...............sp.s..hpTYSHashPs...G.ssshhshhsspst...hctsuThAPoltlplpGscohlscshs.......G.IP	.................................................................hohtshhpl.t....ps............s....ls.sh.s.h.sp.............pl.lWDohPLpphc...up.hsh....pG..apllhsLsus.p.....................ppscsplhhhYp+.hG.p.............sWh...uGp..lh.pssp......................................pspEWuGoshl............p..tsplpLaYTs.........................p.....thhst...hsh.h.sss.tl....hpshpp.+.lh.p.sD.....GhhYQs...tQ............................................as..hRDP..h.D.....sG.phYhlF.E..uNsus.p...............s.t.hsts.p.h.h.....th.p.....................ttA.htsuslGlhhhps.............p.hchhsPLloussVsDphERPphhh.s....GKaYLFT.S+t.phs........suls.u.s-sh..hhhhspt.lhusYhPhN.soGLVLsss.................t.s..htoYSahsh..Pt.......................u....s.shhs..............h.......s..t...............................................phtuT.APohhl.lpus.p.o.h............G.h........................................................	0	18	35	50
+2769	PF00840	Glyco_hydro_7	glycosyl_hydr13; 	Glycosyl hydrolase family 7	Bateman A	anon	Pfam-B_1478 (release 2.1)	Domain	\N	19.60	19.60	37.50	19.70	17.30	19.10	hmmbuild  -o /dev/null HMM SEED	433	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.81	0.70	-6.11	18	5196	2012-10-02 19:29:29	2003-04-07 12:59:11	15	7	239	68	226	5216	4	183.50	64	97.72	CHANGED	QsGT.TsEsHPpLTWp+CTsuGs..CsshsupVVlDANWRWhHpssGtT...NCYoGNpWsoolCPDspTCApNCsLDGADY..suTYGlTTSGsoLoLpFVTpss...tpNlGSRlYLMssDoc.YpMFpLLspEFTFDVDlSpLPCGLNGALYFssMDADGGhu+assN+AGAKYGTGYCDuQCPRDlKFINGpANlEGW.sSssssNsGhGshGoCCsEMDIWEANShusAaTPHPCsssu.QptCsGssCG.s.s....RauGhCDsDGCDFNsYRhGspsFYGsG..hTVDTo+pFTVVTQFlssss...GsLsEI+RaYVQNGpVIpNussslsGlsssssITcsFCsupKssFG-ps.Fsc+GGLspMGcALupGMVLVMSlWDDauuNMLWLDSsYPsssss.tPGstRGoCssTSGsPupVEussPsupVsFSNIKFGsIG.STa	.................................................................................................................................................Y.T.G..N.s.Ws.sTlC...P..D..s..t..o.CA.pNCA.lD.GA...D...Y....sGT.YGI..T.T........S..G.N.u.Lo.L+FVT......pup......uoNl..GSRl..YLM..p..s....D.op...Yp....MFpL.l.N.p......EFTF...DVDVSpLPCGLNG..AL.YFV.pM...DuDGGhuK...a.s.sN......KA..GAKY..G...T......G...YCDuQ........CP+DlKFI....N....G......p..........A..N..lcGWss.Ss.s.DsNAGsGpaGoC.CsEMDIW..........................................................................................................................................................................................................................................................................................................................................................................................	0	86	145	203
+2770	PF02324	Glyco_hydro_70	Gluco_S_transf; 	Glycosyl hydrolase family 70	Bashton M, Bateman A	anon	Pfam-B_965 (release 5.2)	Family	Members of this family belong to glycosyl hydrolase family 70 [1] Glucosyltransferases or sucrose 6-glycosyl transferases (GTF-S) catalyse the transfer of D-glucopyramnosyl units from sucrose  onto acceptor molecules [2], EC:2.4.1.5.  This family roughly corresponds to the N-terminal catalytic domain of the enzyme. Members of this family also contain the Putative cell wall binding domain Pfam:PF01473, which corresponds with the C-terminal glucan-binding domain.	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	809	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.63	0.70	-13.54	0.70	-6.77	12	260	2012-10-03 05:44:19	2003-04-07 12:59:11	11	22	109	32	37	910	3	705.80	50	54.62	CHANGED	LLMsWWPDKpTQlsYLNYMsptshhs..ss..aospssQtpLstAApplQtpIEpKIupptsTpWLRpshssFVKTQPpWN.pSEs....stcDHLQsGALLasN.SshTsaANScYRLLNRTPTsQTGp.t.+hpt...s....GGaEhLLANDlDNSNPVVQAEQLNWLHYlMNaGoIsusDs-..ANFDGlRVDAVDNVsADLLQIAuDYhKAtYGVccs-tsAhpHLSILEAWScNDs....Ys+DpssspLsMDNhhRLuLlaoLs+.................s.shRushpshIs.............suLssRos-sppspshsNYsFlRAHDSEVQolIAcII+cpINPsssGhoh..ThD-lKpAFcIYNpDhtpuDKKYTpaNlPsAYAlhLoNKDolsRVYYGDhYTDDGQYMApKSPYYDAI-sLLKARIKYVAGGQsMps.h..sss.....s........lLTSVRYGKGA.pAoDs.GstpTRspGhuVlsuNpPsL+LssscplslNMGAAHKNQsYRPLLLoTpDGlssYhsDu-A..tthV+hTDspGpLsFsAs-ItGhpNsQVSGYLAVWVPVGAu-sQDsRssuSspsss-G.placSsAALDSQVIYEGFSNFQsFss..psspYTNtlIApNssLFKsWGlTSFEhAPQYVSSpDGoFLDSlIQNGYAFoDRYDluMSKsNKYGot-DLhcAlKALHupGIpsIADWVPDQIYNLPGcEVVTATRsssaGchpssupIcpoLYVupo+osGpDYQupYGGAFL-ELptpYPplFpppQISTGpshDsS.KIppWuAKYFNGoNI.GRGAtYVLpD.uospYasls...sstsFLPKpLssppups.GFspDGp	...........................................................LLMsWWPsKpTQlsYLNYMsp.shhs.........ss....aospssQstLstAuptlQhpIEp+Iu.tp.tsTpWL+phh.......ssFVcTQspWNhpoEs..........sspD.HLQGGALlasN.ss.......h.......Ts.ANS.cYRLLNRTPTsQsGp...phh...sp....GGaEaLLANDlDNSNPlVQAEQLNWLaYlMNaGoIstsDss..ANFDGlRVDAVDNVsADLLQIsuDYF+utYtlsps-tpA.pHlSILEuWSpNDs...tYsc-pssspLshDsth+huLlauLs+.................s.s.R...u......s..lpshls.....................ss..Lss.Rs.p-.s.ppspshsNYsFlRAHDSE...VQslIup..I......Ipcpl..s.s.s.s.sGhoh.....Th-plppAFcIYNtD.ppsc..KcYTpYNlPuuYAlhLoNKDolsRVYYGDLYTDDGQYMtpKSPYaDAIssLL+uRlKYVuGGQsMps.....sp....p...............tlLTSVRYGpGshsAsDp....Gs.s.pT.RTpGhullhuNsPsLpLss.cplslsMGsAHtNQtYRslLLoTpsGlstY.sDpss.....h+hTDspG.LhF............s............ss.............-............l............tG........h..pNspVSGYLuVWVPVGAsssQDsRssu.Ss.pts.ssG.psacSsAALDSQlIYE.GFSNFQsass..psspYTNhhIApNs..s..LF+pWGlTSFEhAPQYsSSpDs.....o.FLDSlIpN..GYA....F..sD..RY..Dl...u.......h.......u.p......s.....sK..Y.G.oh--LhsAl+ALHtsGIpshADWVPDQlYsLPGcElVTATRsssaG..p....h..ts.......u.IpppL...Ysspo+usGp.YQupYGGtFL-cLptpYPplFpph..................t.......IS.............oG..p.hsss.KIppWSAKYFNGoNI.G+GuhYVLp.D...uos..pYasls...sst.h...LPptLhsp..s.s..GF..p.............................................................	0	6	14	28
+2771	PF03659	Glyco_hydro_71		Glycosyl hydrolase family 71 	Finn RD	anon	CAZY 	Family	Family of alpha-1,3-glucanases. 	25.30	25.30	25.30	25.30	25.00	25.20	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.56	0.70	-6.00	53	358	2010-01-08 16:12:28	2003-04-07 12:59:11	9	18	107	0	264	391	4	340.70	30	59.90	CHANGED	hVFAHFM...lG.stsh.ossDWcsDhptAptusIDAFALNlu.....sDsaosppLshAapuAs.....pss..FKlFlSFDa....uhWst....spVhshlppYuspsAQhp.hs.GKshVSTFtG.tsuh.........DW.s...sl+susG........hFFlPsapshustshssh....hhDGhhsWtA.WPs...susshssss.........DpsYhpsL.............uKPYhh................PVSPWFaTphss.....asKN...WlapuDs.LWasRWpQlLpL..pP......c..aVEIloWNDYGESHYIG.....Plps........sht......scustp.aspsM...PHDGWRphhs.aIss..........YKsGtt...sshlsp...............-pllhWYRssP.usuC.sussTo.u....Nssstt..thpPs..-hhpDcl..FhsuLLpu.sAslpVo..uGsssphsas.........ussGl.phsVPh....s..sGp.phslsR.sGpslhsssG	............................................................................................VhsHah...lu....s.........sh...s.scatpDhphApt.ttIDuFALNh...u.......-.s.hp......s....ppls...Aa.puAt............phs......FKlFhSFDh.......s..hst...........splhphlppY.....sspsu.hp....h..s......u..+.shVSTF.t.G....t.su.........................................s.W.t.......sl+...p...t...s...u....................haFl.....Ps...apshs....s..t.....th.th...........hhDG....hasWt....u...WP......s.sp...s.....h.ssts................................................Dtta.hphL..............su+s..YMh................PlS.PWFa.Tp.hss.................as.KN...Wl..a..tu-s...LahpR..Wppllp.h..........pP........p..hVpIloWN.................DYGESHYIG.....Plts..th.............stus.p.as..t..s..h....s.........HsuWhphh..aIshYKsG........shlpp..................................................-tlh..hWYR.ps..s.ss.ss.ssos.s..............tPt..phhpDpl..ahsshLpp...suslp.lp...uuss.t..thp.........sssG.h.thplsh....s........sGt....hpl.R.sst.lhp.....................................................................	0	88	143	218
+2772	PF03662	Glyco_hydro_79n		Glycosyl hydrolase family 79, N-terminal domain 	Finn RD	anon	CAZY 	Domain	Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment.  Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form.  Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity [1].	20.50	20.50	20.70	20.70	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.93	0.70	-5.81	9	293	2012-10-03 05:44:19	2003-04-07 12:59:11	9	9	99	3	160	323	6	232.70	31	49.33	CHANGED	sccuolslpGpstIApTDEsFlCATLDWWPP-KCsYspCsWGhASlLNLDLss.ILhNAIKAFsPL+lRlGGSLQDpllY-sGc.cpPC.ssFpKsoutLFGFopGCLshcRWDELNsFFppTG...................................AhlsFGLNALpGRsh...hsc.........u...shsGsWDaoNApshIcYTlSKGYs.IcuWELGNELSGSGVGA+VuAcpYApDsIsL+sllpplYpss.tspPlllAPGGFFDtpWaTEhLpposss.lcVlTHHIYNLGPGsDs+LIcKILDPSYLDt.upT.FpslpphlpptGohAsAWVGEuGGAYNSGtchVSsoFl.SF...WYLDQLG	..................................................................................................................................................s.......................................................................................................................................................h......hsh.....p.p..hD.L.sFhppoG...................................hpllFGLN.ALhtp..........................sstWssoNAtthlc..Ys.ssKtYs....I.uWEL.......G.N..E....s....u....p.t..h..s.........h..t..lsu....pQhucDhhpL+p.ll.p..p..h..a...pp....s........t....P.l..htP....t.s.......h......s...............p....hh........p.p....hlpt...uGt.....l-slT.aHh.Y..........l.ss....t....t...........th.h..pc.....hLsPp....h.LD.p...h..pp...hp....pl...phl.p.p...hss......t.t.....tsWlGEs.....uuAasuGt..lSssFssuF...haLDpLG........................................	0	43	82	120
+2773	PF01270	Glyco_hydro_8	Glycosyl_hydr20; 	Glycosyl hydrolases family 8	Finn RD, Bateman A	anon	Prosite	Domain	\N	17.50	17.50	18.70	17.50	17.00	16.00	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.11	0.70	-5.72	7	1235	2012-10-03 02:33:51	2003-04-07 12:59:11	12	23	1064	33	227	966	30	329.70	32	84.54	CHANGED	hshshtsshshshhsshssstsutss....tW-paKucalpssG.......RlhcsusuNhsps......EGQGYGMLhAVhhs.....-pshFDsLapascspLpp..hsstLhuW+hssstps.hts...ssATDGDh.IAauLLhAtKpWt.st+hshhp-Ahshhht.hhshhs..sG...sLhPGshGhsps..hthNPSYahhPsht.tFhshTusstWtslh-cshpllspht....upsGLssDWlshs...sssu.t.th-.......as.phShsslRlsh.hhhhs.....spsshlssaht.....hhpshhcshp.shssluostsusas..hssGhhAspssshtp.lss.....thsph.suu......csYausolpLhshlhpst	....................................................................................t.s.tt.ts..s...........tWcpaKpcal.s..ppG..................RVlDs...u..s..u...pp...s.o..S........EGQuYGMhhAlhAs.....D+ssFDplhsW.Tps..p..Lup................hp...p.....p.....L.......AWha.......u..p..........c................p..s..s....phps...........sNoAoDGDlahAauLLcAu..+h.....Wp....p..t..p...Y..s.......hup.Alh.h..........ths.....t.....c.s.............s.......s........l.....s....hG...................s............h..........L.............LP...G..p......h....G........F.....s.....p....s.......s........t....h..c...............h.......N.....P..........SYhs....P....p....lt....p....a.a....s.....t....h.......u....s....s..........W.p.s.ltcssh.c...lLh.csu............s...pGhsP.D..WVthc......tstu.h..p.......t..sp..................hshhu.SYsAl.Rl....h....h.....ahu.....hh..s.....c.......s...s.........pp...u....c...h...ls.pFts..........hssh....s...t.....s..G.h..s.s.p.t...ss.....l...s......o...s..p...s.....t...s...hs..........P....s..G..h...u...A.s...h........s.....h....h....p...s.h.ss.p................ph.s..t...h.sts............csYYs.sL.sLhu.hh..........................................................................................................................................................................................	1	80	127	172
+2774	PF03639	Glyco_hydro_81		Glycosyl hydrolase family 81 	Finn RD	anon	CAZY 	Family	Family of eukaryotic beta-1,3-glucanases. Within the Aspergillus fumigatus protein Swiss:Q9UVV0 two perfectly conserved Glu residues (E550 or E554) have been proposed as putative nucleophiles of the active site of the Engl1 endoglucanase, while the proton donor would be D475. The endo-beta-1,3-glucanase activity is essential for efficient spore release [1].	25.60	25.60	25.90	25.90	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	695	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.17	0.70	-6.52	5	477	2010-01-08 16:09:34	2003-04-07 12:59:11	8	36	230	0	313	469	76	526.10	26	69.41	CHANGED	sPshsc+ShhPsPsphhusDpsssPLpTNKFYsNhhLsss-QPpasHPYSIp.sssSS.aGLAISHsosSQpsah..ssossspalFNPsGltshVFoA+pFsSusslsl-ppchpphpssLSsossoSsalchPLVpGMGFlTulY+.sLsFsls.SSIsFSTIhu.pSlShupuhsKYsIpLsNNpsWLlYAoSPs...spsFsLTlsusSoIpsSsuFoGLIlQIsVlPs-o..NsY.EslhDtuAGsYsssscLsuspsDupsscYcFsasstGYot.GssLMaALPHHhpSFos.-sQsphluptLsSTlcGlMsGYlTcSWsL.csplspplua-PVSlohsSpt.sYSc-uLpcItuAsspDVNsssSsAESslsS.YFhGKlIA+YAplsLlAcEIlaD-slTKpsLpplshAhshLsuNpQshPLlYDsKWsGlISou..GSpSSpADFGNoYYNDHHFHaGYalYAsAVIuhlDP........oWucc.NRcaVpoLlRDa.....ussucSDoYFPphRsFDWFsGHSWAuGLaEsGDGKNEESTSEDVNuhYAsKLWGLshGDo+LlspAsLhLolh+cAhpsYahhcsssoVpPc-FlG.N+VoGILFsNKlDauTYFGscEa..hhpGIHhlPlTPlSuhlRSs.oFVKQ-WNtKlsPII.-oVu-GWKGILauNpALYDPcsAYcpFus.ssFDsuNpLDNGhShTWaLAh	.........................................................................................................................................................................................................................................................................................s..h....Tstah....thh......h......t..t...........h..Ph..h..................................................................h.h.................................................h.....................t..h....................h..........................................................................h...lhpG.saho.............................h....h......h...................................................................p.a.h..h...s...t......ahhY...........................................h.............t...........h...s.t.....h..G.h.hpls......h............t........t........................t......h..h.D...t.ss.h.a...s....htsp...h.........p.....h.p.................t............t.........hpa..p.......h.thtt.t.....G................t.....t.....h.l.h.hA.h.PHHhp.h....................s.........t...t.t...t...........h...s............h.sohcG.hhuh..h.......s....s.......p......h.h.p.................................h...........P.h.............................p...............ths.t.....t..t.h.t.....lht.h.h.p-.l....p...t.......tt..ss.s...o...Ya.GKhls+hA.lhhhs...p.............p....l....h...t...........s..p...s.....h.s....p...........h..h..........hh............p.t.h.hthhh.......s..........s......p......t......t.......s.....h.h.YDstWtGl.lop................................................s........t........hDFG.s.s.h.YNDHHFHYGYalhuuAllupl....Ds.......................sW.....h..pp..........p....s....h...lp...LlRDh...................u.N.s..s..p....s.DshFPhhRsFDhatG.HSWAp.G....l.....h.....t..s..D..........G+spESoSEshp........hhYu.htlaG........h......s.......h.......Gs........p......phpshGsh.h.......hsl.hpuhppYa................h.h..p..s...s.........s........p.....h..................P..tpa.ht...N+...V.....s.G.....llatsKhsasT............a...Fu...s..t.......hltG........Ip.hlPl.hs.hothl..........ts.t....pa.Vppph..........p..........h......h....t....t...h....h....p......t.....h..t...s..s.....Wpul.lhh..uhh.-.tsu...hphhtt......h.t................h..........................................................	0	91	195	285
+2775	PF00759	Glyco_hydro_9	glycosyl_hydr12; 	Glycosyl hydrolase family 9	Bateman A	anon	Pfam-B_843 (release 2.1)	Domain	\N	20.20	20.20	20.30	20.30	19.20	20.10	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.65	0.70	-5.59	37	1983	2012-10-03 02:33:51	2003-04-07 12:59:11	14	98	574	36	722	2026	39	381.80	25	67.64	CHANGED	sYp-ALpKulhFaEsQRSG+L.PsspR..........hsWRsDSGLpDGss...............h.sl.......DLoGGaYDAGDpVKFshPMAaosThLuWushEatsth................tpusplsphhcsI+WuTDYhLKspsu.ss......hasQVGD.....GssD........Hph....WttsEsMshsRssa+lstssPGS-luuEsAAALAAASlVF+ss.DssYuppLLppA+plasF..AcpaRutY...Ssuh.ss.ussaYsShSGapDELhWuAAWLahATs-.....soYLshhps.stphtsts.................sasWDsphsGuplLLA+h.h......p....hppa+sp..s-palsthhss..s.sp...sphTPGGLhah.pWus..LpYssssuFLhhsYuch............s.hssssphpshAcpQlDYlLGsNPhphSYlVGaGsp.PppsHHRs.s.....s+.......suapshhssssPp.phLhGAlVGG..Pss.....................pD.sasDcRssYspsEsAsshNAuhlGsLA	...............................................................................................hh..shha.a.hp+.....s..................G..............................a.tts.u...sh..Dtt.................................................................t.............DlsGGaaDA..G..D..hs..K.........ashs..huh...........o...........s.s.......h.......L....sash.hEhttth.........................tss..s...p..h......s.....c.....hh..ctl+WshDahl+hpst...t.......................hh.h.p.l.....us................ut....sc..............Hth..................Wt.ts..p.....s........h...........s..........h........t.........c......s....s...h......p.....h.....s........t.........p....................u..........o.......s......h...s.u.p.h...A.A....u....h.At..u........u..h......la....+........s..................h......-....s.....s...a..........u...p.p................hLptAc.........p.....hap.a......A...p.....p......h....t...s...h.....................ts..s..............s........s..........t..s.h..Y........ss....s....s...ht.....D.........E......h............hW........AA.s.La.h.u...T...t..p...................pp....Yhphhtp.....h...tt...ht.h.t.t.......................................hsW.sst...h..s..s..st..........h.h..........h...uph......h...................t.................hptht..pt..............s..p..t........h..........hs.thh.................................tt......h.......hs.............s...........t.......Gh.........h....h....h..........h.us....hphs...s...s..s...h.h..l..h..h.ha..s.............................................................................hhtspphh..p.h.A.p.p..p.......l.....sYlLGp........Ns..h...t.h...Sa...h..s...G...a..........G...t....p.........P.............p.p...H..HRh.......................................th.t.h....t......s................Gs....lsGG....P.s.t...............................................tc..ta......D.....t.....h...t.....sa....s..Essh.hN.Ashhhhh....................................................................................................	0	310	549	663
+2776	PF03808	Glyco_tran_WecB		Glycosyl transferase WecB/TagA/CpsF family	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.40	25.40	25.40	32.20	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.77	0.71	-4.86	167	2497	2010-01-08 16:18:29	2003-04-07 12:59:11	8	24	2143	0	522	1664	434	170.50	35	65.78	CHANGED	phlppAcllhsDGhullhuu+hh.u..tsl.........cRlsGsDlh.tLhp.tsspp.sh..plaLlGup.slhcpsspplpppaPslplsGhpsG...ha.........s.t-p.ppllp...pIpp.ups-llhVuhGsP+QEhaltchtpp...lsss.lhhulGusaDhhuGp.hcRAPpahp+huLEWlaRLhpEP...pRlh+c	..............................p.hlppA-hlhsDGhulVhus+hh...s.....psl.............pRVs.GhDLhppLhp..huspc...sh.........pVFLlGuc.s......-...........V......lp.psttpLppp...a.s.slsl....sGtpc.G..YF............p.cccpslhc....cIpt.uts.cllhVuhGs.PKQE.haltcpcpt........hsss...lhhGVGGoaDVhuGp..lKRA.PphhpphsLEWLYRLlppP...pRltRp........................	0	167	342	432
+2777	PF01531	Glyco_transf_11		Glycosyl transferase family 11	Bateman A	anon	Pfam-B_935 (release 4.0)	Family	This family contains several fucosyl transferase enzymes.	21.50	21.50	21.70	21.60	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.12	0.70	-5.43	5	654	2010-01-08 14:30:42	2003-04-07 12:59:11	11	14	365	0	223	638	1259	248.30	22	78.41	CHANGED	sVSllh+spptlsLh.AsWAh......Pshss.s.p+hsu.hcGhaTlslNGRLGNQMGpYATLhALAp..hNGRhAFIPsuMHusLAPlFRIoLPVLpscsupRpPWpNaHLsDWMcE-YcclsGcal+hoGaPCSWTFYHH.LRQpIcpEFTLHDHLREEAQ..shLRsLpls.h.GsRPSTFVGVHVRRGDYVcVMPKsWKGVVuDpsYLppAlDcFRARasuslFVVTSDDM-WCKKNIcsSpGDVsFAGcG.puSPuKDFALLoQCNHTIlTlGTFGaWAAYLoGGDTlYLANaThPDSpFhslFKPEAAaLPEWlGIs	.....................................................................................................................................................................h............................................................................................................................................................................................................................................................................................................................................................................................................h......................t......h...a...h....t......hhp.p....h.............h..php...s.....pl......p.......pt..hp.................th.h...p.t..h..p..ht.........h.....p..s.....p..s....h...V..u.lHlRRG.D..Y.lpsh.......t...........h..t..s.hss...h.s.......Y...h...p..pA....l...c.h....h.....p...................t.....+.......h....p....s......s........h....F...hlh...S....s...-...hp.W..........s....+....c..........s.....l.......s.....h.....t........p..........s.....p....s.......h....h.sss.......................tss..s.hp...Dhh.L.h...o.p..C...pasIh..s....s..STFuaWu.Aa.L.s......t..s..s.p...l...h.l...h.s..p.h.....t..p.................t.h..tW...............................................	0	67	103	167
+2778	PF01793	Glyco_transf_15		Glycolipid 2-alpha-mannosyltransferase	Bashton M, Bateman A	anon	Pfam-B_1324 (release 4.2)	Family	This is a family of alpha-1,2 mannosyl-transferases involved in N-linked and O-linked glycosylation of proteins.  Some of the enzymes in this family have been shown to be involved in O- and N-linked glycan modifications in the Golgi [1].	25.00	25.00	37.10	25.60	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.12	0.70	-5.49	107	719	2010-01-08 14:40:35	2003-04-07 12:59:11	11	10	156	6	528	697	49	307.20	39	74.37	CHANGED	lhh.shhttttp.......................tttttts.tpt.thpth...tpstst.h..tttt...t.............................s+....NAThlsLsR.Np-...L.sllpol+slEcRFN++..apYsWlFLNDcPFo--FKctspshs.Suc...sc.........auhIPcEcWshPsaI...Dp-+hpcshcphtccpIhYGsspSYRpMCRapSGaFa+cslLpcY-aYWRVEPslchaCDl.sYDsF+aMc-ssKpYGFsIulh.E.h.pTIPTLWspsccFh..pppPp...altp.sNhhsalo-..s.....................................................................................supsYNhCHFWSNFEIusLsFaRSc...............s..YpcaF-aLD+sGGFaYERWGDAPVHSIAsuLhLc+ccIHaFcDIGYhHsPa	...............................................................................................tt...............................................................................................+.sAshls.LsR..N....p..-....LtsllpSl+pl..............Ec+FNcp..apYsWVFL.....N..D.tsFs-.-FKctsp.shs....su..p....sp..................aGhI.....P..p.....-.c.Ws.hP.s...aI...Dpp.....p.hpcshp.pht...c..pt.........lhY.G..s...p.SY.+.pMCR.F.S....G................aF..a+H..s.lL.p..p..Y-aYWRV.......E..........Pslcaa.CDl...sYDsF.p.aMpcssKpYGFslulhE..h.pTlPo...LWpp.spcFh...cp..p..sp.......hl....t.p....ss..hhpalo-..c.............................................................................................tupsY..N...hCH....F.........WSN.FEIusLsaaR.Sc...............t..YpcaFpaLDc.sGGFaYER.........W................GDAPVHSIAsuLhLs+sc.I..HaFcDlGYhHss................................................................	0	147	304	462
+2779	PF03076	GP3		Equine arteritis virus GP3	Griffiths-Jones SR	anon	Pfam-B_687 (release 6.4)	Family	This protein is encoded by ORF3 of equine arteritis virus. The function is unknown.	25.00	25.00	291.00	290.80	20.50	17.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.12	0.71	-4.40	3	141	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	2	0	0	140	0	161.00	84	98.16	CHANGED	MGCTYSGPAAFLCFFLYFLFIsGSVGSNNTTICMHTTSDTSVHLFYAANVTFPSHFQRHFAAAQDFVVHTGYEYAGVTMLVHLFANLVLTFPSLVNCSHPVsVFANASCVQVVCo+lNSosGLGELSFSFIDEDLRLHIRPTLICWFALLLVHFLPMPRC	...MGpAYstPVAhLCFFhaFLFIsGSVGSNNsTICMHTTSDTSVHLFYAANVTFPSHFQRHFAAAQDFVVHTGYEYAGVTMLVHLFANLVLTFPSLVNCo+PVsVaANASCVQlVCs....p....s.N...So....s....G....LGElSFSFIDEDLRLHIRPTLICWFALLLVHFLPMPRC.	0	0	0	0
+2780	PF04724	Glyco_transf_17	Glyco_tranf_17; 	Glycosyltransferase family 17	Mifsud W	anon	Pfam-B_5914 (release 7.5)	Family	This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression [1,2].	21.70	21.70	23.20	22.00	21.10	21.60	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.45	0.70	-5.45	12	306	2010-01-08 16:27:10	2003-04-07 12:59:11	8	5	175	0	202	296	1469	291.40	27	74.31	CHANGED	hhshS+h+sh.+th....hh.hhhhh.hslhslhh+tpplohhhRPlW-uPPp.FstIPHYatcNhoM.sLCpLHGWthR.-hPRRVaDAllFSsEhDlLplRa+ELhPYVspFVlLESNsTFTGhsKPLhFtp..p+sp.FcFlcs+lsYshlssh.hcpGc...sPFltEuYpRsAL..ctLlRluGlpsDDllIMuDsDEIPStcTIphL+WCDshPplhHLcL+pYLYSF.....................pa.sDspSWRAohHhapsG+TcYtH.RQosplLsD.........uGWHCSFCF+.lp-FhFKhpuYSHsD+sRascY...Ls.cRIQclICpGsDLFDMlP.EEYoFp-lhtKhGPlP.ohSAVHLPuYLLcNh-cY+aLLPGNChRcu	.........................................................................hh.....................................................................................h.............h.....t.......s......R+....lhDshhh.s.s..E.lDlL.-lRhpELhshVDhFVl.lE.Ss..h...Tap.G.h...KsL.hFtp....pp...tp..F..p..h..hc...s.Kl....h..Y.h.......h....l..s.........th......................t..up..............ss..a.........t-.s.....a..p.....R...s.....tl................ptl.h....p.....h..t...s........h.....p....s...c.D..lll.huDs.DEIP.s.....cslthL...+h..tc.....shs....p....h....p.hp.h.+..hY...uF................................................a....h.....ss..p....h...p....t.......t......t..h...h..........s...h.p....p.h.....t...........p....p..s.s...t...l..lhp......................uGWHCSaCFp..p.....ph..h.h...Kht...u..h...sHs-.h....p.h.tta.............hs.p.hI.pphlppGt.haDh...p.h.....................P..h.......................................................................................................................................................................................	0	73	120	165
+2781	PF03033	Glyco_transf_28		Glycosyltransferase family 28 N-terminal domain	Griffiths-Jones SR, Bateman A	anon	Pfam-B_1105 (release 6.4) & Pfam-B_2764 (release 7.5)	Family	The glycosyltransferase family 28 includes  monogalactosyldiacylglycerol synthase (Swiss:P93115, EC 2.4.1.46) and UDP-N-acetylglucosamine transferase (Swiss:P74657, EC 2.4.1.-). This N-terminal domain contains the acceptor binding site and likely membrane association site. This family also contains a large number of proteins that probably have quite distinct activities.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.42	0.71	-4.41	43	6160	2012-10-03 16:42:30	2003-04-07 12:59:11	15	40	4548	35	1693	4850	1858	138.00	25	33.17	CHANGED	lllsssGTtGcl.PhlAluppLpcpGacVp...luspsshpphl..ppsGlshhs..lsss.....................................thht...hhpthtsshpt..th.thhphlt....phshthsshhussshhush.....htthshhltEp.ulPhhssphhshhssphhh	..............................hllsuGGT.u.G...HlhPsl....Alupp.L....p......p.................p......G.........a..c...lp..........hlGop.....s...s....hE..pp..l.....h.p..p.......G.....l...p.......h.ps........lsss..........................................................................................s.hpt.hh............h...p....t.h..t....s....s.hc.h......h......p..u..h....h.p.....u..t..p....l.......l.....p...c.......h.....p.......s...c....s.....l......h...u.........h..G........G.....a........s....u........s......P....s.h..lAAh...........hhtl.P.s.llHEpsuhsGhsN+hhsphspph..h........................................................................................................................................................................................................	0	541	1110	1453
+2782	PF04666	Glyco_transf_54	GnT_IV_N; Glyco_transf_55; 	N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4541 (release 7.5)	Family	The complex-type of oligosaccharides are synthesised through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyse the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyses the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide).  In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein [1].	19.90	19.90	19.90	20.00	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.72	0.70	-5.68	18	495	2010-01-08 16:26:41	2003-04-07 12:59:11	8	9	124	0	316	424	6	244.80	33	57.08	CHANGED	tths..........hpthpsssppl.pplsp...........phhh.hhsH.....hhcctu......slpPslltGpsRssVu.lVlGlPTV+Rp+poYLh-TLpSLlsphot-Epc-sllVValA-oD..salpplspplppcFspclpSGhl-VIusstpaYPshssL+coasDsp-RV+WRoKQNLDYuFLMtYApscGpYYlQLEDDllsp+sFhsshKpFssppsu......pcWhhLEFSpLGFIGKlF+SpDLspLlcFhhMFYp-pPlDWLLsHahhl+sC..tt.s...C.t.hpphhIRa+PSLFQHlGtpSSLpG+.hQ+LKDc-F	.........................................................................t.t...........................................................ph....th.hu...s..h..pt..hp...lslGlso....VpR.....p..t..t....s.YLhpTlpSLhppho.pEpp.....chh..ll..V..hlu-............sD....p........a........h.pths...tp...lp...p.Fspc.l.uGhl....lIpss..paY.P.s..h....s..p.l+....p....shsD..s.p.cRs..paR..o.KQ.N.lDYsaLh...a.s..p.s..p.u......t.YYl..L.EDD.lhsp.s.a..hsph....+phhhp...hps............................ppWhhLE.F..SpL.GaI..G.K.......h..a+u..DLshlspFhhh.F.Y.p-hPhDaLLschhh.lhs..............................tp.hlpacPSLFQHhGhhSShtup..p.hp................................................	1	73	104	181
+2783	PF03414	Glyco_transf_6		Glycosyltransferase family 6	Bateman A	anon	Pfam-B_4383 (release 6.6)	Family	\N	25.00	25.00	25.80	25.50	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.11	0.70	-5.98	6	613	2012-10-03 05:28:31	2003-04-07 12:59:11	8	8	118	121	171	620	297	246.90	53	92.10	CHANGED	htPpVhssphthshWhsthhpsshp........s.phppsctc.ccppptscl.cplp.pshh.s.pRs-VLTlTPWhAPIVWEGTaNpAlL-phYthQplTlGLTVFAlGKYlc.aLccFLESA-+aFMVGH+VhaYlhsDDsuchPhVpLGPhRplpVhEl+scKRWQDISMhRMcTIu-HIht+hpHEVDaLFChDVD.VFpD+aGVETLGpLVApLpshaYtAs.psFTYERRc.SsAYIPhsEGDFYYtuAlFGGosscVhplTptCapuILtDKtNsIEAtWHDESHLNKYFLhpKPoKlLSPEYhWD.+l.GhPuslKpl+hoh.sKpashVRN	........................................................................................................................................................................pluhhhhAh.t.....+Ylt...FLc..hFLEo....AE+aFMVG..HRVp..YY.VFTDpsus.V.P..c..VsLGsGRpLsVlcV.pu.h.p.RWQDlSM+RMEhIu-ahccR.hhpEVDYLhChDVDhc.F.pD+lGV.ElL.......s...s......LhusLHPu.a....Ys..ss.RcsFTYERRPpSpAYIP..psEGDF..YYhGuhFGGoVp-V.+LT+sC+puhhhDpsNuIEAhWHDESHLNK.Yhlh.p.KPo..K.lLSPE.Y........hW.........D..ph.s..ss..l+hh+h.h...K...................................	0	7	24	62
+2784	PF01075	Glyco_transf_9	Heptosyltranf;	Glycosyltransferase family 9 (heptosyltransferase)	Finn RD, Bateman A	anon	Pfam-B_839 (release 3.0)	Family	Members of this family belong to glycosyltransferase family 9 [1].  Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.29	0.70	-5.16	18	6767	2012-10-03 16:42:30	2003-04-07 12:59:11	12	124	2063	9	1547	5234	3651	225.80	19	64.03	CHANGED	htpLtcsLppps.aDhllshpshlKSAhlsthhutsh+hGhctpot...husLhhs+phshsh.tthtVpRhttLhsps......hshstspspsphslshtptsttpsths............ttPhlshhPuuot....ssKpWPt-patcLsptLpcpG..hplhLhsuspc...-cppscplssuhc........hsslssKhsLppsstLlutAshlVusDoGLhHlAAALs+PllulYGsTsPthTs....Phucptssls..phtttsshpppshhsphp	.........................................................................................................................................................................l.pt.tt.aD..hh.h.......s....h..............s...............h.......p..s....s......h....l.....s...h...h....h....t.............h........h...p..h....u.....h...t..h..t.t..............................h..........t....h...h.....h.....................................................h....l....p....p............h...th...hh...............................hs..h........................................h........h......s.....t......h..t......h.....t..hs........................................tt...h..l.sh......t...s...u.....uph........ssKp......W...s.....t.......p.p....a....s.p.l.h...p....t...l..t...p....p......s.........hp........l...l...L..h..u..uspc............tpp.h...h.p...t..l.s..p..t.h.t...............................shs.l.....s....s..c...h...s....Lt..p....h....s....sllsp.u....c....hhlusD...oG.hH...lAu...Al.s.p........P......s..lu.l.........a......G...s......o.....s.....s...t...h..hs...............sh....s....t..p........h.......h............................................h.................................................	0	478	953	1279
+2785	PF00274	Glycolytic	glycolytic_enzy; 	Fructose-bisphosphate aldolase class-I	Finn RD	anon	Prosite	Domain	\N	19.20	19.20	19.30	19.20	18.10	19.00	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.02	0.70	-6.05	58	2226	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	1445	193	546	1888	2485	252.40	41	94.39	CHANGED	ELhcsAptIsuPGKGILAA.D..ESsGThGKRhssIGVENTE-NR........RtYRpLLFoo.sslsphISGVILF-ETLYQpss-.GpsFV-lL.+cpGIlPGIKVDKGllsLsGoss.EosTQ........................GLDuLucRCApYhKsGA+FAKWRsVLcI.....s..sssPSpLulpENApsLARYAuICQpsGLVPIVEPEILsDG-HclcpstpVTEcVLAtlaKALsDH+VhLEGoL.LKPNMVTsGpsss.p..+.soPpplAhhTVpsLpRoVPsAVPGlsFLSGGQSEE-AolNLNAhNph.............sh...+PWtLoFSYGRALQsSsLKsWtGKsEN...lpAAQcthlpRA+ANutAslG+Yssss........sssuspoLaltsasY	.........................ht..upGhlAh.D...pS..suoh..sK..thtth.s.....l...p.........ps.p.sp..............+thRphlho....s....s....h...............ht.ph....I.G....sILFcpTh....p.t.......p.....G..h...........hsphl.tppGllshlK....VDK........Gh.ss...h.s..ss......st...pshp........................GLDsLh.cR.s.s..p.ah.h..GspFuKWRsVl...pI.................t.PS.thuIt.-sAp......sL.ARYAslsQp..pGLVPIlEPElh...cu...p...H...chctpthlpppl.httl.ph.t-p.pVhLc....hol.hcsshh.tsh...............tp....................................Vst..........lshLSGG.S.....c-cAs..Lst.s.th............................hSauRALtts.lth..tsp....t.................................................................................................	0	175	303	423
+2786	PF01102	Glycophorin_A		Glycophorin A	Finn RD, Bateman A	anon	Prosite	Family	\N	22.70	22.70	22.80	22.70	22.60	22.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.65	0.71	-4.35	5	139	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	43	6	29	143	1	95.20	40	58.86	CHANGED	HT.SsSGSso.t.ISo.......oNDspspsStuTP........TtspEVosthssRsh.P.EpG..-slQLsHDFScsVITLIIFGVMAGlIGTILLISYsIRRLIKKSsuDVpP............hPsP..tDs-VPLSSVEIEsPE-	..................................................usss.t.los.......sssppppsohsss........stsp.cs.S.plo.sps.l.sspp..p....-p..s....Q....lsH.cFots.......I...hhIlhsVhAGl.IG..hI..L....lI.YsI....pRhhK..........................................................................................	0	10	12	18
+2787	PF00606	Glycoprotein_B		Herpesvirus Glycoprotein B	Bateman A	anon	Bateman A	Family	This family of proteins contains a transmembrane region.	18.80	18.80	18.80	19.50	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	714	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.34	0.70	-13.22	0.70	-6.50	40	1279	2009-01-15 18:05:59	2003-04-07 12:59:11	13	17	240	20	36	932	2	309.30	28	74.43	CHANGED	phsFRVCus.usGu-llRFptspsCPs.hspscsasEGIhllaKcNIsPYpF+VphYhK.lThsosasGh.shs..tlospasc+hPlPhhElst.IDppspChSusphsp.sshhhssac+Dsh.spsh.LhPschtosss+RahTss-hYss.Gsh.hhY+osToVNChVs-spARSsaPYcaFshuoGDsV-hSPFashp..ssp.hs....csss+Fp.lcsYphlDhtsc...hstsssspRsFLppsc.hTluW-htscpsssCshshWcp.hscslRsEts.sSaHFsupslTATFlosh.sphshsps...pthsClpccspctI-clatpcYNsTHlpsGsl.p...hYhTsGGhllsaQPlhspsLschhttphspsssssss.t.........................Rp+Rsssssstt......................................shpopssltaAQLQFsYDpL+salNchLuclAcAWCcpQpRpthlWpELoKINPoulhSAlaG+PVuA+hlGDVluVocClpVsQso.VplppSMR........lsusss....hCYSRPlVoFcahNsop................................hhpGQLGpcNEILLspphlEsCphssc+YFhsGsshhhYc-Ytas+plsls-Issl.sTFlsLNlohLENhDFpsLElYo+sEl+so.sVhDlEplhR-hNhasp+ltslcpslps...sspsshlpGlsshh.pGLG.slGculGsVluuluGAluShVoGlsoFlpNPFGuhslhLlllAsllslalhaR+hppltpsPlchLYPhss...p...shppps	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.hRph.t............................................p..psh..hu.....lQFsYsplpt.lNphhtpl..uWC..Q.+p..hh.th.pl.........................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	12	36
+2788	PF00802	Glycoprotein_G		Pneumovirus attachment glycoprotein G	Bateman A	anon	Pfam-B_1049 (release 2.1)	Family	This family includes attachment proteins from respiratory synctial virus.  Glycoprotein G has not been shown to have any neuraminidase or hemagglutinin activity (Swiss-Prot). The amino terminus is thought to be cytoplasmic, and the carboxyl terminus extracellular.  The extracellular region contains four completely conserved cysteine residues.	20.70	20.70	20.80	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.95	0.70	-5.24	4	4325	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	47	1	0	2618	0	121.00	55	83.44	CHANGED	hKTLc+sWcs.pahIVh.SCLYKLNLKSlsQhALSsLAMIh.TSLlIsAIIaIuouNpKspsTosss.phTpQhpNpTosahTpps.puspsSpQuTTos..pThssssT.Gs..phtHoTspTpsppT....T.stspKPshpsptspPPcp.pDc.cFplhsaVPCSICpsN.sChSlC+phspptPsKtsThpPpKpPpsKTT.KKsoKT........oTp+.Tp..ThhpsKsNhoTP..slLoosp..............................HsTs	.............................................................................................................................................................................................................................K+D.Ks.spp.PK..c...sTTpP.T.cKPThp..TTcpshpT...TlLsosTotp.E+.................T.QppoLHSTo........................................	1	0	0	0
+2789	PF02885	Glycos_trans_3N	glycosyl_transf_3; 	Glycosyl transferase family, helical bundle domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Domain	This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase.  All these proteins can transfer a phosphorylated ribose substrate.	20.90	20.90	21.00	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.75	0.72	-4.38	135	7326	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	4261	62	1772	5253	2054	66.00	26	16.80	CHANGED	phpphl.cclhpu....psLoppEspthhptlhsGphs...........cspluAhLhAlph+G...pos-ElsuhscAh..tppup	.......................pllp+h....tcG.....psLop-Ehpthhst.lh.....s..G.p.ls.........................-hQl...uAhLhAlph+G....o.pEl.suhspAMhppu.............	0	546	1116	1479
+2790	PF00534	Glycos_transf_1	glycosyl_transf_1; 	Glycosyl transferases group 1	Bateman A	anon	MRC-LMB Genome group	Family	Mutations in this domain of Swiss:P37287 lead to disease  (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety  of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP,  GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.91	0.71	-4.84	63	44775	2012-10-03 16:42:30	2003-04-07 12:59:11	15	435	6658	103	12903	42366	19227	161.60	18	38.27	CHANGED	sppp.ptphsh.psphhllhlGRlthp.KGhchllcAhttl.t.........tsshpLllsG..........tsp.ppphpphspphtlpsplhhhuhhs..pclhphhpt....uclhlhsSth....................EuFGhshlEAhusGhPllsos.ssGhs-llpcst........sGhllpss...sscslsctlppllpsp.......phppphsppupph	..............................................................................................ht.................p..t....h..l..h...h...l...u.....R....l....t...........p....K........s.......h....p....h....l......l.....c.......u...h.tp....l.....................................t..s....h........p....l...h....l....h....G................................................pss....t...t....p...h....p......p.....h.....h......t........p...........h...........t..........h................t..............s................p...........l.........p....h...........h........G......h...........h...........s.............................p..........l..t.....p....h......hpt.............u-..l....h.......l.....h...s.S.hh.........................E...s.....h......u.....l....s....h....l...E......A.h....u.t....G....h.....P........l..l....s....s.....s........s.......s..........u........h......t.....-........h..l...t...s.st..................................sG....h..........h....h..........t.........st..........s............................p..............s...........h....s....p....t....l....t....p....h...h....t...p..........................h........................................................................................................	0	4440	8647	11076
+2791	PF00591	Glycos_transf_3	glycosyl_transf_3; 	Glycosyl transferase family, a/b domain	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Family	This family includes anthranilate phosphoribosyltransferase (TrpD), thymidine phosphorylase.  All these proteins can transfer a phosphorylated ribose substrate.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.42	0.70	-4.98	21	7137	2009-09-11 15:42:01	2003-04-07 12:59:11	16	28	4318	62	1734	5172	3200	239.20	30	60.81	CHANGED	shshlDhsGTGGDGtsThNlSTsuAhVsAAs.Gs+lAKHGNRulSSKSGouDlLEul.Glsl.phss-psp+slc-sGluFLFAPtaHsuh+assssR+pLsh+TlFNlLGPLhNP.ApsphpllGVast-LspshAcslppl.shp+uhVVHG.sG.....hDElohtupThVsclc.su...clspaslsPpDhGlppsplpsLpusss.cENtchlc.slLpGpsssh.....t-hlshNAushlhluGhsso.......LcpGsptAt-slcoGpAh	.......................................s..hlDhpuTGGs.G....ss.o....Shss...A..llAus....G.l......h...........VuKp..u..s.R.u.l.u......s.p..u.G...o..h..D..hL.Eul....G.....h...p..l..ph.ssc....phtc.........h..l........p..c..........s...G..l..u..h..l....h..u..s..s..h.h..ss....h.c.+.h.h..s.c+...-l....s.s........T...l..s..l..PLlss........................................................ulh.st...clst.s.h.stll...h....c...l......s.....s.....t......pu.h....h.h..........+.....u..............................hD.E.sshh..u........po..h..V...s....hp....sG...........................ph.p...p.h..h.l...o.s.......s...hsL..s..p.s...............h.t.........s...............s.l.c..s.................p...Es.h.p.hLp...shh.tG.t...t.s...................................t-h.lh.h.t.u.u..hh..l.h..h.....u......s......h.....s..p..s.......................lpcuh....thstpslpsGpA.................................................................................................................................................................	0	557	1116	1464
+2792	PF04413	Glycos_transf_N		3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	Waterfield DI, Finn RD	anon	COG1519	Domain	Members of this family transfer activated sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides.  Members of the family transfer UDP, ADP, GDP or CMP linked sugars.  The Glycos_transf_N region is flanked at the N-terminus by a signal peptide and at the C-terminus by Glycos_transf_1 (Pfam:PF00534).  The eukaryotic  glycogen synthases may be distant members of this bacterial  family [1].	23.90	23.90	24.60	26.30	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-5.13	154	2390	2012-10-03 16:42:30	2003-04-07 12:59:11	11	13	2271	8	551	1796	2084	180.60	36	42.32	CHANGED	htp....chtE...RhGhh............................hlWlH.AsSVGEshustPLlctLtp...phPshplllTosTsTGtphs..pph.....h....s....ps.pta.hP.hDhshslp+FLpphpP.....chhllhEoElWPNllttspppslPllLlNARlSc+Shptap+h.s.h..hhpthlppl..shlhsQsptDupRhhsLGss.pp...lplsGNlKaD.hs..s	...........................................................................hp+htERaGhhtt.h........................ssIWlH....usS.VGE.shAuhPLlctLcp.............c.hP.sh.slhlToh.TsTGt-ps...pph...h...........sp.....slp.phY..LP..aDh.stslp+FLsph..pP.....clsllhET.........ElWP.........Nlltth++cp.......l..PlllsNARLSs+Sh.tsYt+h..s...t...hh+pl.l.ppl..shlhAQscpDupRahsL.G..sp.........p...lpVsGslKFDl..h.......................................	0	170	347	455
+2793	PF01153	Glypican		Glypican	Finn RD, Bateman A	anon	Prosite	Family	\N	25.20	25.20	25.60	25.50	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	558	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-12.90	0.70	-5.90	15	584	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	88	10	343	500	0	364.70	25	92.27	CHANGED	hsl.Lhllhshsu.stu.ssscu+SCuEVRphYt.u+GaulsslPpstIuGEHL+IC.PQGaTCCTscMEE+huppS+h-Fcshlc-uospLpsllsspa+pFD-aFc-LLppuE+oLsphFspsYGcLYsQNuclFp-LFoEL+pYYhGus..l................NLEEhLs-FWu+LLERhF.+LlsPQYp....ho--YlECls+ts-....pL+PFGDsPRcL+lQlTRAFlAARsFlQGLslut-VVs+sspV...shospCsRAlMKhhYCPaCRGl.....sslKPCpsYClNVM+GCLANQAD.LDsEWpsaIDuLltlA-+.lpGsaslEsVltsIcV+ISEAIhshQENusplosKVFQsCGsP+.sssts....husp-t...p+ch+shs.Ec+PTsusss......L-pLVo-l+p+L+ph+pFWsoLPsslCscchsuussssc...CWNGps+u.RYhscVhGsGLsNQlNNP.EVcVDIo+PDhsIRQpIhpL+lhTs+L+sA.................................hsGsDlDFp.Dss.D-sSG.SGSGsusscc....hsssutchshssssspp.t.hsh.................sptssoushspssshhhh..lhsllshhhthh	.........................................h............................................................................................................................hp...............phh..llp.upp.htthF.psat..hh.ps...hhtphasclp.ahh.t.us.....h................................................slpchltcFaspLh.hha..ph.hps.th..................s.ch.pC.ltt...hp....plpsF..GphPp.....lhhp.ht+uh.ssR...hahpuLthu.h-Vhpp.s.tpl..............s..tC.ptl.h+h.aCshCpGh................................pPC.saC.sVhpGChu................t..s.p.ls..Wpth..l..sh..ls.......pt.h.s..............s...h.......-.sh.sl.......hl...p-ul...hpps..t.....pl..s.t...p.......l.........p.h.Cu.s........t.................................t.......p.p...s....................................h.t..h..chhtplp........tha..tLs...lCtp.....p..h....t....t.........CWsG.th.....s...pY.......hh.t..s..tp......Eh....h.p............................p...h..p.h.tLp.h.t..h...h..........................................................................u...................t..................s......t.....................................................................................................h............................................................................................................	0	64	95	210
+2794	PF05199	GMC_oxred_C		GMC oxidoreductase	Studholme DJ, Bateman, A	anon	Pfam-B_891 (release 2.1)	Domain	This domain found associated with Pfam:PF00732.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.74	0.71	-3.90	85	8000	2009-09-10 15:44:39	2003-04-07 12:59:11	8	92	2304	146	3849	7618	4016	132.70	26	23.46	CHANGED	PpSc.GplpLss..s-shs.P.....hl.chsahssst...........D.hpthh....pulc.hstclhpss....................................................tthhshs.......thpssp...........h.thhht...h..shhHss.GTspM.Gts.t.......uVVD.sph+VaGlpsLpVsDuSlhPsh.sssssphsshulA...c+s	...............................................................................................................oc.Gplplps..........tcs......h.t....P..............hl.p.sahs...p...t........................D...hph.hh......puhc.hspc..l.hpp....................................................................................................................................tth..st.........................t.h.tssp.............................h...th.h.tt............s....sshH.............ss.GTs+M...Gs...ssp......................uVVD...s.......p....h.+....Va.......G.............lp.......s.L+.V..sDuSlhPph..su.sNss..sssh..hluE+h...................................................................................................	0	1059	2161	3210
+2795	PF00732	GMC_oxred_N	GMC_oxred; 	GMC oxidoreductase	Bateman A, Studholme, DJ	anon	Pfam-B_891 (release 2.1)	Domain	This family of proteins bind FAD as a cofactor.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.74	0.70	-5.26	20	7804	2012-10-10 17:06:42	2003-04-07 12:59:11	14	78	2279	50	3835	7620	5057	264.90	27	47.78	CHANGED	h-tLatuGGshuos..........................................................ssphhhl.sGpslGGuSsVNhusslRsstpshc-WsschGlphauspchhshhcplp........................tpluV..sspshppsstN..pslhcuuccLGas.t.lscNssus..+.sGhCthG...CtpGtKpuospsaLhsAh.p+.supllossps-+llh..............ttpst+AlGVtspsssss.....hpphhhss+pslluuGAltoPtLLtpSGl.pspc..............lG+NLplHPs	........................................................................................................................................................................................................................DhlllGuGsuGs.slAsR.L.......s.....................p............s...................s.....t.........h.....p..V.....ll.lE....u.G.....s...........................................h...t..h....h..h...........h...........t...........t.......h..........s......h.....t...........h................s...........t.........s......p........................t.................h.................s.......s.......p..........t...........h....................h...................p..G.........+....s...........l.G..G..u..Ss..l..N.u........hh........a...h.........R......s.....p..t.........t........D........a........-........t........W........t........p..................G........t........s........W..........s.......a......p......p....h.h........s...a...a...c.+hE.p.......................................................t..h..p..u...h....s.......G............l.....t....l.............p...................................p.........s....hh..........p............s....h..h..p.........u....s....t.......p....h...G.h....................................h.s.t.....-.....h..s.st.........pt.p...G....h....s.......h....h.....t................................t.....t...................p.............G..............t........R.......h.......o.......s.s..p.......s..a...L............t............s........s..............h......p..........+.................N..............L........p....l..h..s..puhV.p+l..lh..........................................c.....s....p.....+.....A...s....G.....V..p....h..hp.s..stt............................h.p..h...h....s....t....+....-..VlLuAG.u..........l..so..Pp.LL..h...........h........S.......G.l.G.......stt.L....t.......t..h...........s...........l................................h...........h..............p......hs..tVGpNhtDH..t..................................................................................	0	1106	2163	3210
+2796	PF00446	GnRH		Gonadotropin-releasing hormone	Finn RD	anon	Prosite	Family	\N	18.50	18.50	18.50	18.50	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-4.93	0.73	-5.27	0.73	-3.70	25	259	2009-09-12 07:42:02	2003-04-07 12:59:11	12	2	122	0	37	236	0	10.00	83	11.90	CHANGED	QHWSHsWpPG	QHWSaGWhPG	0	2	5	16
+2797	PF03071	GNT-I		GNT-I family	Mifsud W	anon	Pfam-B_2207 (release 6.4)	Family	Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, GLCNAC-T I) EC:2.4.1.101 transfers N-acetyl-D-glucosamine from  UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localised to the Golgi  apparatus, and is probably distributed in all tissues. The catalytic domain is located at the C-terminus [1].	25.40	25.40	25.40	25.40	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.76	0.70	-5.94	4	372	2012-10-03 05:28:31	2003-04-07 12:59:11	10	10	147	7	215	355	35	315.40	31	71.55	CHANGED	hhAshhhhaIthhLFhh.opYA-phssulcucNpssuphph.l.clu.pQsRlVtLEc...hhpp.s--lpplRuhlps..ht.cuhs+lshssthsVhsVlVhACsRAshlc+slcplL+Yp.PsApKaPlhlSQDsucpsV+ptshSY.splTYhpHL..Dhpslss..Puc..hpAYYKIARHYKWALsQlFhc+pFSpVIIlEDDhEIAPDFF-YFcAstsLL-pDcolhslSuWNDNGppQhVcs..P.sLYRSDFFPGLGWMLpppTWcELpPKWPKAaWDDWhRh.Ep++GRQhIRPElsRT..hsFGc+GuShGQFFsQaLc.IKLNDhhVcapphDLuYLhcsNYsKcFsshV.+pAh.lpssclshpshs...cG.-VRlpYcspl-FcchAcphGIh--aKsGVPRsAY+GIVsFphps.RRVaLVsPco.lpthssc.	.................................................................................................................h............................................................................................................................................................................................................................s.hslhV.hAs.sRss.l.+hlcpL...lphp.....s.....s.......s........p.....h...lh.V........D.s........p....p...s.h...p..........h.lt...a............l...p...h.l.pp..........................p.s.l.t.h.....st.................t..............+..lu...p.HY+huLst..hF...p.....h..t..h.......p............t.....slllE.................-DL-l...AsDFFpYFpt.sh..LL...c....p.D.o.la............ClS............AWN....D..............s.G..............h.....pp.hsc...s....................s...p.....h.....L....Y...Rs-hhPGLG.WhLh....+pla.p........E...Lp...PK...W.P....p...s..........h...W..D...WhR.sppR+sRtCIh.P-lsRo...........hp.F.Gh....h............G...h.s.......G..aa....c.t.ahc..h.+h.N................p........l.t....h......p...t..s...ls..L.....c...................-tYc.thht.l..tu..l.p.....h.....pc.......................................................................................................................................................................................................................................	0	102	128	177
+2798	PF02447	GntP_permease		GntP family permease	Bateman A	anon	Pfam-B_1928 (release 5.4)	Family	This is a family of integral membrane permeases that are involved in gluconate uptake. E. coli contains several members of this family including GntU Swiss:P46858 a low affinity transporter [1] and GntT Swiss:P39835 a high affinity transporter [2].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.44	0.70	-6.00	12	5095	2012-10-02 15:12:49	2003-04-07 12:59:11	11	8	2135	0	706	3333	363	403.30	34	98.00	CHANGED	hsLlhlslu.lllLLlLll+hKlpsFlALllVuhhVGlstGMslscllpohpsGhGGTLGplAlllGLGsMLG+lls-oGuAp+IAhThlppFGcc+lpaAlllsuallGlslFaEVGhlLLlPllFslA+puplsllhlulPhsAuLsssHuhlPPHPGPhslAshhsADlGtslLYGlllu.lPssll...AGPLasK...ahpphh..t.p.....st.hstchhpcpchPuFGlSlhshllPllLMhhpTlsplhhscssshhs.....hhpFlGsPssAhhIAlLlAhaThGhtRGhshpplhchhspulsshAhlLLIIGuGGuFKQVLl-SGVGchluphhpshslSPllhAWllAAllRluhGSATVAslTsuGlls.....Pllsths...sss.tLlsLAsGuGSllhSHVNDuuFWlhKcYhslo.lpETh+TWTlhpTIlSlsGLlhsl.Lhull	................................................................h..llhh.hlu...lhl...ll.l..Ll..h.+....hK......h.....p.s..Fl...u.L..l...l....s...uh.h...s............u............l............h...t............G........h.........s......h...........s.........c.............l............l.........p...........s.........h...p......s.......G....h....G..u...T...L.Gtl...u...l....l....lu.hGshlG+l...ltcoGuAppIApollpph....Gc.......+.......+.......st....h..A.......l.........s.....l..s....u.h..l...l.......G.l....s..........lF...........a..-....V.u.h.V..l....Lh..Pls.h.s....lA.+......p.......s.......t.......h................s.......h.l.hl..ulP.h.s.uu..l.s.s...s..H..s.h.l....PP.p.......Pu..P..h...s..h....A...s..h...........h.......t..A..s.....l.....G...h......s..l....l.....h..G....l......l..lu....lP...ss...l...l...........A...G....la.s+......................h..h..t.p......h.......................................t.....h.s....t....t....h.......h...s...p....p........p.h.............P....u.....h....u.........h.......o...l.......h...s.....h.l..l..P.l....l........L..h.h.......h.....p.s....l...u..p.....h.........h.....h.....s........t.......s.....p..s...h.ht............................hh..p..F.....lG....s.....P.....h..h.......A....h..h.......Ius..l.l.Ah.a.s.hG..h....t........p..s..h........s.h....p.p.....l.............c...............h....hsp.....u....l.t..s.h.u.h....l.l...L....l..l..G..uGGsFtplLh...-....SG...luphl....up....h...h.............p..............t.............h....s.............l..s....s....l...lhuallAs.....llRlA.GS....A....T....V.A...h....h.T.A.u...Gllu.............P.h.l...st..h.s........sls.s...t..lh..s..l.A..h.u....uGS.l.h.hSHV.N.D..u.G.F.W...l..h.p.....c.a..hsho.lt-TlKoW...ohhp....Tlluls.G.hlhsh.llsh.h.....................................................................................................................................................................................................................	0	172	385	568
+2799	PF00392	GntR	gntR; 	Bacterial regulatory proteins, gntR family	Finn RD, Bateman A, Hoskisson PA	anon	Prosite & Pfam-B_6405 (Release 8.0)	Family	This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerisation domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR [1-2][4][5]. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships [3]. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor [5].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.87	0.72	-4.53	26	49014	2012-10-04 14:01:12	2003-04-07 12:59:11	16	87	4089	55	10949	36460	2838	63.00	29	23.05	CHANGED	hhpplhppLcppIhpGphpsGspLPsEccLuspauVoRsslREALppLtscGllptppspGshV	..........................h..tplhppl.cp.t.I....h....p..G....p....h....t..s.G...s....p...L....P...s.-cp...L..u.p...p...h......s.V.S...RsolRcAlppLt.pc.G..l..l.pt...p...p..s..p..GshV..................	0	2975	6426	8851
+2800	PF02188	GoLoco		GoLoco motif	SMART	anon	Alignment kindly provided by SMART	Motif	\N	20.70	20.70	21.00	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.27	0.72	-6.70	0.72	-4.52	46	1105	2009-09-10 20:12:23	2003-04-07 12:59:11	12	99	91	10	542	983	0	22.80	44	8.24	CHANGED	s-cFa-Lls+sQ.upRhDDQRspl	......-cFF-Llt+sQ.usRhDDQRss...	0	104	151	308
+2801	PF04178	Got1		Got1/Sft2-like family 	Wood V, Finn RD, Fenech M	anon	Pfam-B_7371 (release 7.3) & Pfam-B_8991 (release 14.0)	Family	Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae.  Got1 is thought to facilitate Sed5-dependent fusion events [1].  This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein (Swiss:P38166) [2]. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments [1].	21.80	21.80	24.00	23.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.57	0.71	-3.99	103	970	2009-01-15 18:05:59	2003-04-07 12:59:11	7	13	313	0	645	936	31	114.90	25	66.90	CHANGED	thGlhhhhlu.hhhhhslhh...pshhFuhhaolGslhhlh............uhshLhGspp..thc.hhhppp.Rhhu..ThsahsulhloLh.....huhhhcshhLsllF...ulhp..........h...........ssllhahl..ShhP.hGt.....sslphhhsh	...................................................hGhhhhhh.u.h.hhhhshhh........hhsp.h.hhholGNllhls.......................uh.s.hlhGstpphp.hh.h...p..pp..+...lhu.....Thhahsulhl.sLh...............huh....h....l...c.....s.....hslsllF.........shh...........................hslhh.ahh..uh.P.hGp.....shlp.h...h..............................................................	0	220	359	523
+2802	PF00516	GP120		Envelope glycoprotein GP120	Finn RD	anon	Pfam-B_44 (release 1.0)	Family	The entry of HIV requires interaction of viral GP120 with Swiss:P01730 and a chemokine receptor on the cell surface.	19.90	18.00	19.90	18.00	19.80	17.90	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-13.00	0.70	-6.27	24	146453	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	446	117	0	119635	0	228.30	54	78.04	CHANGED	LWVTVaYGVPVWK-AossLFCAo-s+.......slWATpsClPosPssQElsLssVTEsFshWc..NshVEQhpEDIhSLaDQSLKPCVKLTPLCVohNCschpt.................sssTsss.......................sttthtctEh+NCoFNhTs.hRDKpcphhshFYphDlVshssss............tophhlIpCNTSVITpACsKs.a-sI.l+YCAPAGFAlLKCNDccasGpuP.CoNVSsVpCT+tIcssVSTtLLLNGShAEpcshIh.scshs......sNsphIllphphslsIsCpRPsNpThh.thhhu...GpsFaohtplhs....lRQAaCphst.pWspslppVtppLtcp.p.p......psIsFs.psu........................GGDPElsha.FNCtGEFFYCNsotlhN........W.psp............ssps.......pphhlPCRI+QIINhWpcVGKshYAPPhcG...pIpCsSslTGLllsh..Dusssss.......pThhssuu-h+-.WRuELh+YKlVcIpPlGlAPT+sKR+slt...REKR	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................E..t..c..l..........h.I.R...Sc.N.h.o.........s..Ns.K.sI.IV..p..L..s..c..s..V..p...Is.C.T..R...P.s.N......N.TR...+......u...l....p.....lG....PG..p..u.F...Y......u....T......G......c...I....IG.....DIR.Q..A.H.C.N...l...St..sp.....W.N.p...T.L.p....pl.s.p..KL.p.cpFtp..............p..sI.....Fp...s.u.........................GGD.....El.h..h..h.....h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+2804	PF03010	GP4		GP4	Griffiths-Jones SR	anon	Pfam-B_1094 (release 6.4)	Family	GP4 is a minor membrane-associated glycoproteins. This family contains envelope protein GP4 from equine arteritis virus.	20.10	20.10	22.70	38.10	17.90	16.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.23	0.71	-4.61	3	72	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	2	0	0	68	0	139.50	93	100.00	CHANGED	MKTYGCIFGLLLFAGLPCCWCTFYPCHAAEARNFTYISHGLGHVHGHcGCRNFINVTHSAFLFLNPTTLTAPAITHCLLLVLAAKMEHPNATIWLQLQPFGYHVAGDVTVNLEENKRHPYFKLLRAPALPLGFVAIVYVLLRLVRWAQQCYL	MKhYGCILGLLLFVGLPCCWCTFYPCHAAEARNFTYlSHGlGHVHGHcGCRNFINVTHSAFLFLNPToLTAPAITHCLLLVLAAKMEHPNATIWLQLQPFGYHVAGDVoVNLE.NKRHPYFKLLRAPAhPLGFVAIVYVLLRLVRWAQQCYL	2	0	0	0
+2805	PF00517	GP41		Retroviral envelope protein	Finn RD, Bateman A	anon	Pfam-B_44 (release 1.0)	Family	This family includes envelope protein from a variety of retroviruses. It includes the GP41 subunit of the envelope protein complex from human and simian immunodeficiency viruses (HIV and SIV) which mediate membrane fusion during viral entry. The family also includes bovine immunodeficiency virus, feline immunodeficiency virus and Equine infectious anaemia (EIAV). The family also includes the Gp36 protein from mouse mammary tumour virus (MMTV) and human endogenous retroviruses (HERVs).	25.10	25.10	25.10	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.54	0.71	-4.76	23	40495	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	166	141	21	37279	0	171.40	74	29.32	CHANGED	huAsALshosQs+pllushhppppplhsslpt.pclLphplhslcp.l..LpsRVpulE+alcsptphs.hGCs.+p..hC+TshPh....hN.o.....Ws..NhThpp..Wpcplp.lppplhpllt-spppptpsh.shppLss..ht.hhs...WhshssWl............shIphslhlllhllsLpllhtllps.hh..phh.GYpsl.............ph.lhcspp.spst	................................MGAAS.lT.LTVQARp.LL.SG...I...VQQQ.sN.LLRAI.E.A.QQHLLQLTVWGIKQ....LQ.ARVLAV.ER.YLKDQQLLGIWGCSGKL.....ICT.Ts...VPW..NsS.....W....S.....NKSh.............spIW.s......NMTWMp......W-..+.EIsNYTshIYsL..lE-.SQ.s.QQ..E.KN.Ep..-.LLt.LDK..WAsLWN....WFs.Io.pWL............WYI+IF.IhI..V.uGllu.LRIlhh.llph.ls....+lR...p..GYpPl.................ph..................................................................................	0	12	12	12
+2806	PF02925	gpD		Bacteriophage scaffolding protein D	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	41.10	41.00	18.70	17.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.66	0.71	-4.40	2	78	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	54	10	0	51	2296	139.30	87	92.82	CHANGED	.sh.psVpatTulAul+hlQASAVLDlTE-DFDFLTusKlWIATDRsRARRCVEACVYGTLDFVGYPRFPAPVEFIAAVIAYYVHPVNlQTACLlMEGAEFoENIINGVERPVpAAELFAaTLRl+AG.p-slhDAEENsR	.....sEpuVpFQTAlASIKLIQASAVLDLTEDDFDFLTusKVWIATDRSRARRCVEACVYGTLDFVGYPRFPAPVEFIAAVIAYYVHPVNIQTACLIMEGAEFTENIINGVERPVKAAELFAFTLRVRAGNpDllscAEENlR	0	0	0	0
+2807	PF00044	Gp_dh_N	gpdh; 	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. N-terminal domain is a Rossmann NAD(P) binding fold.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.99	0.71	-4.25	112	14213	2012-10-10 17:06:42	2003-04-07 12:59:11	19	19	8352	412	2317	10425	3516	130.00	46	43.38	CHANGED	l+luINGFGRIGRhVhRshh.....tp.scl-l.VAI...NDhs.sscthAaLhK.....YDSsHG+a.sspVp..hp........sst..lhl.sGc...p.Ip.lhsc+-.PtplPW.tphulD..lVlEuTGhF...psp-pup.t.....Hlp..u.GAKKVllSAP..u+st.......ssohVhGVN.ccpassp..pllSNASC	............................plulNGF.GRIG.R.shRth.............tt....tt..lc..l..VAl................N...D.....h..............s.......sp..h.h...Aa...h.l+.....YDo....sH.Gp.F.......p.......s.......p......Vp....hp......................psp......lhV...sG.c..........t.Ip....lht....c........+...s....P.t...p.....lsW...t......................p..hGs-..hVlEsTG.h.F........ssp....-...cAp.t...........Hlc........u...G..AK.....KVl.I...SAP....uts..........sshhVhGVN.c-.ph...c..s...s.....pllS.NASC..................................................................................................	0	709	1371	1873
+2808	PF02800	Gp_dh_C	gpdh_C; 	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.81	0.71	-4.77	71	15479	2012-10-02 22:00:43	2003-04-07 12:59:11	15	25	9082	412	2355	11397	3548	142.80	53	50.30	CHANGED	LAPlsKVlp.-pFGItcGhMTTlHuhTusQphlDss....+DhRcuRuAA...NIIPoSTGAAKAVuhVlPcLp.GKLsGhAhRVPTssVSllDLssplcKs.soh-ElssAlKcAuc.......s.hcGlLuYo--.lVSoDahusst..SSlaDuptohsls.....sphVKlluWY	.............................................LAPlAK..V.l.p.Dp...F.G...I.hc...GL...M..TT.......l.H.....uh..T......u.s..Q..ps.lD...u...Pp......K...D.....h.Rt...........u...RuAu............tNI.IP...oSTG..AA...KAVG.c.VlPpL.s....G.........K.L.s.G..........hAh.R.......VPTssVSl.V....D.L..os.p.L.c......K.s........s....o........h....-.....-lpts.l.....K......pAup.................................s.h.+.G.lLuY.T....-....-...l.VS..sDa...usst....oSlh.Du..tt.shshs......tphlKlhuWY.............................................	0	719	1391	1898
+2809	PF05024	Gpi1		N-acetylglucosaminyl transferase component (Gpi1)	Moxon SJ	anon	Pfam-B_4796 (release 7.6)	Family	Glycosylphosphatidylinositol (GPI) represents an important anchoring  molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to  phosphatidylinositol (PI). This chemically simple step is genetically  complex because three or four genes are required in both yeast  (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively [1].	20.80	20.80	22.40	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-4.63	7	347	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	276	0	237	333	2	167.60	35	30.43	CHANGED	phhsplh.lhlDlshGlhlh.hLh...Nhphlsshhhphst.ashcpLpohlthLhssPhGlKLNsplsphluphhlahIclW.oahshhpshl.......hlhhhluh.u.hhGhohhluhlhDhlslhohHlhshYhhss+LhshplpslsuLapLFRGKKhNlLRpRlDoh.YshcQlhLGTlLFolLlFLhPTh	................................................t..hs.hh.lh.DlhlGhhlh.hlh............tpht.l..st...h...t..h..h.p......................hhhctLpphlpW.L.h..u.h.PA..GLKLNppLsthLGchFLahIp.h.W.t.s.h...l..t..h..hp..s.hl..................................hll.h.h....l.u.h.u.....hhG.hoh.l.ulh.Dllsl.lT.hHlasaY..hh..su...+laphplphltSLapLFR.GKKhNl..LR.p.R.lD.........o........p........s.........Ys.........lD.........QLhlGTlLFTlLhFLhPTs...............................	1	82	132	199
+2810	PF04113	Gpi16		Gpi16 subunit, GPI transamidase component	Wood V, Finn RD	anon	Pfam-B_7012 (release 7.3);	Family	GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex.  Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase  that adds glycosylphosphatidylinositols (GPIs) to newly  synthesised proteins.  Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small  C-terminal, cytosolic extension with an ER retrieval motif [1].	20.20	20.20	21.40	20.80	17.60	18.40	hmmbuild  -o /dev/null HMM SEED	564	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.93	0.70	-6.50	11	458	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	272	0	326	480	1	374.60	25	89.91	CHANGED	L.Lhshlhlsssssu.s.st........sYcEsLhL+PLPpspLLASFpFcu............ssstssapppcachFPRuLuQILp+uss+ELHLRFopGRWDsEsWG.spPasGhppGGTGVElWAWl-usscpt....................Acc+WhsLTpuLSGLFCASLNFI.DSocTTcPshoFp.sustss.....tp..sh+LhaGsLPtEsVCTENLTPFLKLLPCKGKAGIuoLLD.GHKlFDusWQSMuIDVpslCsss.sp.Chlpl-QoVDhVlDl-RoKR.+.......s.sspph.C-pSKsYpsc.hCaPhtpssptsWSLs-lFGRslpGsCsLuc...tpssVsLpV........................P.phpVhsp.thht......pssstspsaslpsss......saDlhlPt....p.o....phssh-pPslpApRolsGaGQ-RGGlphhhsNPSsp.............sl-FIYhEpLPWFlRhYlHTlpspls.......tpttsssshlcclaY+PulDRc.+uTpLElphslPst.STlsLTY-FEKulLRYsEYPPDANRGFslssAVIolhs.s.........................pssshplRTouLLlsLPTPDFSMPYNVIIhTSTllALAFGulFNlLsRRalstEcutshptpshhs+Ltt+lht....+l+	....................................................................................................................................................................................................................h..................................................................................................................................................................s.G.at...au.........................................................Gh.h.......s.h.................................tta..l.t.hsuhhssuht.h.............................h..........................................hhhu.LstE.hC.T.ENLTPhhcLLPst....stsGlssLhp.....pl.a.ps..apo.t.l..h...p.........t..................h...hp......h..h............................................................................h.h.that.....h......t.....s..s..........l.h.....................................................................................................................................h..h.................hph.h....................................s........h.stp...h.G.u.p.pGth....h.s..t..................................h.hhhhp.lPWahp.ahpoh.ph...t...............................................h.h....s....u.p..+......tst....hch.h...lPst.ps...............h...ht......hphc+..hLphtEasPDss+Ga.l.s.ul....l..h...........................................................................h..hhopslLl.LssPDFSMPYNVIhhssThhulhaG.hhshhh.+.h......................................................htth.............................................................	0	116	207	282
+2811	PF02831	gpW		gpW	Bateman A	anon	[1]	Family	gpW is a 68 residue protein known to be present in  phage particles. Extracts of phage-infected cells lacking gpW contain DNA-filled heads, and active tails, but no infectious virions. gpW is required for the addition of gpFII to the head, which is, in turn, required for the attachment of tails. Since gpFII and tails are known to be attached at the connector, gpW is also likely to assemble at this site. The addition of gpW to filled heads increases the DNase resistance of the packaged DNA, suggesting that gpW either forms a plug at the connector to prevent ejection of the DNA, or binds directly to the DNA. The large number of positively charged residues in gpW (its calculated pI is 10.8) is consistent with a role in DNA interaction [1].	20.90	20.90	20.90	21.30	20.70	18.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.38	0.72	-4.42	5	521	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	332	3	23	146	0	67.40	62	95.68	CHANGED	MTcpp...ELQpARsAhHDLhTGKRVVS...VQKDG.RRVEYTAoSluDL++YIs-LEuQLGhot.RRRuPlGVRl	.............Msp.t....ELt....AhRtAhhDLhTG.KRV.so.....VQKDG.RRlEaTAsSls-Lp+hI...s-hEs.l..G...h....Tp..RRRtPhGhhl...................	0	3	10	18
+2812	PF04965	GPW_gp25		Gene 25-like lysozyme	Bateman A	anon	COG3628	Domain	This family includes the phage protein Gene 25 from T4 which is a structural component of the outer wedge of the baseplate that has acidic lysozyme activity [1]. The family also includes relatives from bacteria that are also presumably lysozymes.	25.30	25.30	25.40	25.30	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.18	0.72	-4.46	181	3115	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1505	1	550	1824	1365	100.80	22	74.20	CHANGED	sshss...htp.slp.......pslptlLsTphGpph..............................h.saG..ls-lhstsh..ssssttplpptlppultpa.EPRlp.hhpV..plts........................tspl.phplpup..lh.p...t.t..ls	.....................phhcplp.......pslpplLsT..usph..................................th.saG....ls.c.hh..sts.....stshttplpptlppAlh.......+........a...EPRlp.hhpVplp........tp.............sspl.shplpuhlh.p........hhh..............................	0	111	282	426
+2813	PF05084	GRA6		Granule antigen protein (GRA6)	Moxon SJ	anon	Pfam-B_6204 (release 7.7)	Family	This family contains the granule antigen protein GRA6 which is found in the parasitic protozoa Toxoplasma gondii and Neospora caninum. GRA6 protein plays an important role in the antigenicity and pathogenicity in these organisms [1].	22.10	22.10	22.10	132.00	20.40	22.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.48	0.70	-4.81	2	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	4	0	3	51	0	183.70	91	94.90	CHANGED	MApsthhhRp+RsFsPlTVshlAVshVsFMGV.lsShGusssAssstuVcts.pthsS.Gt...AVGToE-YVNSSthuGupscu.AEs-pputtsEsDVpP.sVh..spEttu.ups.s.pERhEEtsst.+.ssVpps.spssuKRpQtRHRlIGssVlAssVAhLhhhF.RRpu...........GusctG..............GcsEsGuE-	.MAHGGIHLRQKRNFCPLTVSTVAVVFVVFMGVLVNSLGGVAVAADSGGVKQTPSETGSSGGQQEAVGTTEDYVNSSAMGGGQGDSLAEDDTT.SDAAEGDVDPFPVL..ANEGKSEARGPSLEERIEEQGTRRRYSSVQEPQAKVPSKRTQKRHRLIGAVVLAVSVAMLTAFFLRRTGRRSP.EPSGssGGNDAGNNAGNGGNEGRG.tGcs-.........	0	2	2	3
+2814	PF00267	Porin_1	Gram-ve_porins; 	Gram-negative porin	Finn RD	anon	Prosite	Domain	\N	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.16	0.70	-5.17	18	5868	2012-10-03 17:14:36	2003-04-07 12:59:11	16	2	765	89	237	5994	230	301.00	39	93.43	CHANGED	KsGNK...........LDLYGKssGhHhaos.csus-.....GDpoYuRIGFKGETQIsDpLTGaGQWEYsspusssEup.ssp..ttTRLuFAGLKaG-aGShDYGRNYGVlYDlpuaTDhhPEFGGDoh...stsDsaMpsRusGlAT.YRNsDFFGLVDGLsFALQYQGKNtp...............scshh......+pNGD........GaGhShoY-hu..shuhuuAYssScRos-Qt.t.............p..utG-+A-sassGuKYDANNlYLAshYupTpNhT.hu.............shuhANKsQNhEVsAQYQF.DFG.LRPuluYlpSKGKDlsu.........ths-pDLVKYVsVGATYYFNKNMSsaVDYKINhLDcss.h..t.GlsoDDhsAVGLVYQF	........................................................................KsGsc...........hshh.....s.....ch.s.u......h..+....h.....h..os.....pp...u...p...c.........hs.p.h.h..s+.l.GFKGpp..p..l.s..s.t.........Lpu.h.................h....QhE.......p.......h.......p...........s......s............s.......s........-..........................................t...............s...........t..................ts.....R.u.........FsGLK..u-.aG.ohchGR......s...h......u......l.......l.......h......D.......s.....t......s....h..........s.......D............................P....................u...G.csh......................hts.s...s...a.....h.....p......t..............c....s.....p.....s..l...........u...........s.........Yc....s.....s......-......F...h...G....l....s.......s......u......l..p..a..A....h..p.......p....u.p.st...........................................................t...t..hh..............+.p.N..G.D......................u..a..t...s...u...h..s.Y...c.......s......G..................h...h....sh..u........u..u....Y...s..p..p..s...c...s...s.c...p................................................s....s....s.c..+..t.p.....s.a..p...h..s....h....t...Y.......D...s...N...s...l.....Y......l..A..s..t.......u..p...p...p..s.h..p...hs...................................shs..s...K..s...p....s.......h.....E...l....s...A......p....h.......p....a........c.....F.......G....l......p....P.......p....l.......u......Y....h...p.....u.h...s...t.s......lps......................hs-.p..s..h.h...c.......l..s..V......G..A.pY...F...sK..p.....h..S.....s..h.....V.....s...h.......t.....h...............h.....s.......p...sp............................h.....s.....s...........s......h.....s.....u..l..GhhapF.........................................................................................................................................................................................................................................................	0	18	57	141
+2815	PF00746	Gram_pos_anchor		Gram positive anchor	Bateman A	anon	Pfam-B_457 (release 2.1)	Family	\N	20.50	17.00	20.50	17.10	20.40	16.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.04	0.72	-4.03	84	9438	2012-10-02 15:23:12	2003-04-07 12:59:11	16	692	1185	11	443	6888	16	38.70	27	4.73	CHANGED	spssptppLPpTG..pssshhhshhGh.hhhssuullhht++	...........t..tpptppLPpTG....ppss.s...hh..s..l..hGh..l.hhhhusllhh++.............	0	110	196	316
+2816	PF01271	Granin		Granin (chromogranin or secretogranin)	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	27.70	26.30	23.80	24.90	hmmbuild  --amino -o /dev/null HMM SEED	586	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-13.02	0.70	-5.80	9	290	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	53	2	101	264	0	329.00	22	89.82	CHANGED	ts+s-p.Vh+CllEVlSssLsKsSPsPlo.EChEsLcpsccclpspEpppN.ssh.tl+hLpD.A-stt....stpt.su.s.....ph.h.s.....tEsGu+sREpps.........s...tcph...h..c..tpp..ccp.c.hph...h.-ttpccph.ctssElsEsh.s.pspAohccshpElu+h-s.sp.p.RE+scccpKs.p-ss--sh+spshPtEs.ssspstss.............pEuEEspspE.s+c..+.psc+scShsscpp.uGphsh--E.............................s..cptphspcp+shSuh..........hhspG+pppptptccuccp.tcth-cps..p-ls.osshps..p-t.+tlc..sGcp.ttts-sstchps.tsh--cscs-.sHsph.cs...tc-th.s+tPps.......phLshG-ph...G.....th...p......c.ppEEsh..................h.LpppahD.tpWpppcpp++t.hs-phLE..tEEcs-hshsM+spFPEh..s.............uYtKR....sPt.sL+RtactsupEDuLctaht.ts...sct.uEEp+c...ts.pE-soAN+...ht-EDpELEsLuAl-tELpKlA+capshRRG	...............................................................h.ph...ht.t..p..s.s...cshphlc..tpp....h.....p..p...t.s.............hp...p........t......t..t......................................................................................................................................................................................................t.............t.................................................t...t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	11	33
+2817	PF00396	Granulin	granulin; 	Granulin	Finn RD	anon	Prosite	Family	\N	20.90	20.90	22.50	21.20	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.76	0.72	-3.86	94	1181	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	140	9	509	1067	2	43.50	48	31.13	CHANGED	TCCphss.Gs....WuCCPhspAVCCsDthHCCPpGa....pCshpsspChp	.......................TCCph.s..Gs......WGCCPhs.pAVCCsD+h.HCCPpGa....pCshpt.spCh.....	0	196	261	377
+2818	PF04495	GRASP55_65		GRASP55/65 PDZ-like domain 	Finn RD, Bateman A	anon	Pfam-B_3985 (release 7.5)	Domain	GRASP55 (Golgi re-assembly stacking protein of 55 kDa) and GRASP65 (a 65 kDa) protein are highly homologous. GRASP55 is a component of the Golgi stacking machinery. GRASP65, an N-ethylmaleimide- sensitive membrane protein required for the stacking of Golgi cisternae in a cell-free system [1].  This region appears to be related to the PDZ domain.	27.70	27.70	27.70	27.80	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.86	0.71	-4.19	37	638	2012-10-02 11:12:46	2003-04-07 12:59:11	9	5	271	6	397	620	5	118.60	38	48.11	CHANGED	hpVassKstphRplpl.sP...............Sshass..................uLLGlolcasshp.ss-plWHVL-V..ssSPAthAG.LhPaoDYIlGss..........sllp..............................spcslhsLlEs+.s+.............................sLpLaVYNo-pDssREVslsPspsWGG-...GuLGCslGYGhLHRIPsh	......................................................................................................................................Ghthp.t....sspp.s..aHVLcV.p.ssSPAthAG.LcP.ahDaI...l...u.h.st......................shLp..............................-.s.-....s.L..hs...Ll..c.s.p..s+..............................Pl+LhV..Y..Ns...c..s...p.ss.R.E..V..plsPs.ptWGGp............G.LGs.l..................................................................................................	0	138	198	303
+2819	PF04723	GRDA		Glycine reductase complex selenoprotein A	Kerrison ND	anon	DOMO:DM04874;	Family	Found in clostridia, this protein contains one active site selenocysteine and catalyses the reductive deamination of glycine, which is coupled to the esterification of orthophosphate resulting in the formation of ATP [1]. A member of this family may also exist in Treponema denticola [2].	21.90	21.90	22.30	23.10	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.72	0.71	-4.50	3	223	2012-10-10 17:06:42	2003-04-07 12:59:11	9	1	110	0	49	188	4	84.70	42	95.03	CHANGED	SlFsGKKVIIIGDRDGIPGPAIEECLKuIssEVlFSSTECFVUTAAGAMDLENQp+VK-ATEpaGAENLVVLlGAAEAESAGLAAETVTAGDPTFAGPLAGVELGLRVYHAVEPEFKuEVDuAIYDDQlGMMEMVLDVDuIIEEMpSIRu	...........................................................................................................................................................................................................	0	22	40	44
+2820	PF01272	GreA_GreB		Transcription elongation factor, GreA/GreB, C-term	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This domain has an FKBP-like fold.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.43	0.72	-4.27	137	7631	2012-10-02 13:30:10	2003-04-07 12:59:11	14	15	4301	28	1688	4424	1946	77.30	33	45.59	CHANGED	hss.....spVthGupVsl..ps...ssspppsaplVGs..........pEuch...pps..pIShpSPlupALlG+c.hGDplplpsPsG.php.hcIlplph	...................................t..p.spVhhGupVpl....ts.....ss...s...-...c..p..papI.VGs...................................sE.ucs.........pps.......tIShpSPlu+ALlGKc.hGD....p....l.p.l.ps.PsG..p....hp..hcllplp..................	0	512	1024	1380
+2821	PF03449	GreA_GreB_N		Transcription elongation factor, N-terminal	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This domain adopts a long alpha-hairpin structure.	21.80	21.80	21.80	22.00	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.29	0.72	-3.92	134	5904	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	4289	22	1237	3294	1838	74.30	42	42.85	CHANGED	hp.....tp.h.lTtcGhc+LcpELcpLtpscRPclsctlspARspGDLuENAEYcAAKccQshl-uRIppLpppLsp.A.pl	.....................p..h.hThcGhc+.LcpELcpLcpscRPclsptIstA.RuhG.DLSENAEYcAAK-cQuh..lEu.RIppL-ptLpsApl........	0	399	789	1035
+2822	PF01184	Grp1_Fun34_YaaH		GPR1/FUN34/yaaH family	Finn RD, Bateman A, Wood V, Studholme DJ	anon	Prosite	Family	The Ady2 protein in (Swiss:P25613) is required for acetate in Saccharomyces cerevisiae, and is probably an acetate transporter. A homologue in Yarrowia lipolytica (GPR1) has a role in acetic acid sensitivity.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.36	0.70	-5.04	58	1687	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	1218	0	658	1121	22	193.00	37	86.80	CHANGED	FG...Gshs....PG.........htP.sp+phANPAPLGLsuFulTTFlLuhaNspshGlssPNllVuhAhFYGGlsQhlAGlWEhthGN...TFGuTAhoSYGuFWlSauslhls..sFGIhsAYtst.t...........hssAlGhaLluWsIFThhhhlsTlKSTluFhhlFhhLslsFlLLAsuph.......osstsltpAGGhhGllsAhhAaYsAhAGlAsppNSa..hh..sh.lPhsp...pt	..............................hs.............................p+hA.N..PuPLGLhGF..uh..TTll..L.s.laN..s.....Gh........h..s..l.....s...u.......l..l..l........u...hu...l.FYGG.luQlhAGlhEa++G.N.......TFGhTAFoSY.....Gu...........FWLoh.s..s..l.l...l.....h....phGls...su..............................................s..ph.l.G..hY......Lhh....W.u.....lFTh..h.M.hh...u..T...L+.s............sh.sl...h.lFh.sLslhFhLL..Alush........................................s.u.s...t.s.l.hp...h.AG..ahG..llsuhsAh..YhAhutllN.pphup.........h......tt............................................	2	200	379	560
+2823	PF01025	GrpE		GrpE	Bateman A	anon	Pfam-B_817 (release 3.0)	Family	\N	25.80	25.80	26.60	26.00	25.40	25.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.97	0.71	-4.70	111	5353	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	4825	8	1413	3716	2850	180.10	28	89.19	CHANGED	pp.............ttttpsphpshppp............lpp............................hcp.......chc.....ch..pcphh..........RthA-h-.Nh++Rh..p+-hp.phpcauhpphhpc...LLsllD...sl-+Alph...........pspphp.......slhcG..lchshcphhphL.pchGlptlss.h.GctFDPphH-..Altph........tssp.hts.ssllplhppGYplp.-R...llRsAhVhVup	..............................................................................................................t.tttptpppt........tttt.tt..ppc........................ltp........................................h.pt................ph.p...............-h....c-chL.....................R..hp..AE.h-..N.......h...+.......+Rs........pc-hp.......psp...c..a..u....hpch.s.p....-.......l.L.PllD...........sL-RA.lps...............tstphp..............................................sl.hcG...lch..shcpl.hpsl.cc..h.Glctlss.......t...G......p..t..FDPshHp...Altp..h...........ss..sc....hts....ssl.spVhQ+GY..p..Lp..-.R.....llRPAhVsVu.................................	0	485	928	1199
+2824	PF02955	GSH-S_ATP		Prokaryotic glutathione synthetase, ATP-grasp domain	Griffiths-Jones SR, Bateman A	anon	Structural domain	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-5.13	37	1779	2012-10-10 13:17:03	2003-04-07 12:59:11	11	6	1678	4	426	2863	2533	171.60	52	54.80	CHANGED	EKLa.stpFs....chh.PsTLVopchpcl+pFhpcpsD..lILKPLsGhGGpulFRlpps.DsNlssllEhhTptsp..p.lMsQpalP-lpcGDKRIlllsG-Pls......ulsRlPt.tGEhRuNlAsGGpucsppLoc+-hcIsppluPpL+c+GLhFVGlDVIGshLTEINVTSPTGlpEIcphts	.....................................................EKLa.ss.Fs....-l.s.P.T.LV.T..R...s....t.s...p..l..+s....Fhp....c.....H......u..D.....lI...LKPL..D....G...M..G..G..uu..I..FRlcp..........s.....D................s.............N..........L....u..........s.....I........l...E...o....L...T.....p...t......G..p...............c..h..sM...AQpY......L....P....s..I...c..c.....G....DK....Rl..LlV...DGE.P..VP................YsLA.R.....I....P....p.....s..G..E...s...R......G.....N.L...A...A..G...GRG......E...s...p..s..Lo...-....p.Dhc....I.Ac.p.l..G.P...s..L.+.c+.G.LlFVG...LD..l..I.....G.D.....h.....L..T.EIN..VT.SPT..ClREI-t..t....................................................................................................................	0	103	240	337
+2825	PF02951	GSH-S_N	GTS_N; 	Prokaryotic glutathione synthetase, N-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.30	21.30	21.60	21.70	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.54	0.71	-4.30	155	1672	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1622	4	395	1136	1521	119.20	46	37.80	CHANGED	l+luhlMDPlpslslt+DSoaAhhhEAQpRGHplaahpsscLth.c.....sG..........cshApspsl.plppsts..........saa...phuptp.phsLuc.hDllLMRpDPPFDhpYlhATalLEps.....pp....tusLVlNcPpulR	..............lKlullMDPIusINI.cKDSoFAMhLEAQ+RGa-LaYh-.sDLhl..p......sG.................csp.Ac.s.+sl....pVc....pshs...........cWa.....ph.s..s....cp....clsL.u-.lDVILMRKDPPFDh...E......a.I..Y.A.T.YlL..E+.A....Ec.....pGsLlVN+PQSLR....................................	0	89	217	308
+2826	PF03917	GSH_synth_ATP		Eukaryotic glutathione synthase, ATP binding domain	Mifsud W, Griffiths-Jones SR, Finn RD	anon	Pfam-B_2922 (release 6.5)	Domain	\N	25.00	25.00	25.50	25.20	24.00	24.00	hmmbuild  -o /dev/null --hand HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.16	0.70	-5.87	10	535	2009-01-15 18:05:59	2003-04-07 12:59:11	12	14	352	15	323	538	43	395.70	31	92.73	CHANGED	h-hcphDpchLpcLshDAlsWAhLpGLlhs-+osp+SGsVsuV.lsauPlsLLPoshPcutacQAsplpPlFNELVDRVS.DusFLppoLS+TpKs.....D-FTuRLl-IHpKh......Lcp..NKKp-lRLGlaRSDYMlD...-pTpu....LhQIEhNTISsSFuGlushlopLHpplLpphsc...thul-upplPsNsulpthA-ALAKAWscY...............ssPcAlllhVVQsEERNhaDQ+hlsupL+c+atlsshR+slAEl-ptuclpsD..........hsLhlsGQtVAVVYFRuGYoPsDYPSEpEWcARLLlEpSpAlKCPsIuhHLsGTKKIQQELA+PGVLERFL-sK.--lA+LRcsFAGLWSLDDo.....-lV+pAlEcPEhFVhKPQREGGGNNlYG--l+psLh+Lpc..oEEcAAYILMp+IhPpss.pshLlR.sGhhcpscsISELGIaGsYLRN..+DcVlhNppSGaLlRTKssoSsEGGVAAGFAVLDSlYL	..........................................................................................................................................................hh.thh.hsh.pGhhhh......................................................sPh..oLh..Po.hPcthappuh.t.lp.haNpLh.s.t.lu......p..s...t.aL.tp.hl.......p.p...hh...ps......................D.p.Fsu.p.Lhplatph.................................hpp......sh.h..p.t..l...............LG..lhRSDYMhc.......tts...t.................................l+QlEhNTIusS.Fuu.lu.shsstlHph.lhp.....h..h................................p............t.......p.l.s.t..N..p.s.htt.l...utulstA..hp..ass.pss.hhhh....h.h.ppth.t.th......hhhhth......t.................................................................................th...t.thsshhatsshhstph.spttWpsRhhlEpStAlKCPsl.hpLsGoKKl.QQ..L........u......p.......s................s.............h....L..p..pF..l.......................s................t......p....p..h.tp.........lcps..F......ss.has.....L..-...............s.......................s................p......h..................h....t.....Ah......p..p..P..p...paVLKPQR.EGG..GNNlYtpp..l.phLp.p..ltp................pchsu...aILMphI.....P.....ts..hh.l.....R....s.....s..................h............................t.p.h........lSELGlaGs......hlhp................tt...p......l.......lhN.....p.p..sGaLlRTK.t.pssEGGVuuGhuslDo.hL...................................................................................................	0	114	178	269
+2827	PF03199	GSH_synthase		Eukaryotic glutathione synthase	Mifsud W	anon	Pfam-B_2922 (release 6.5)	Domain	\N	20.90	20.90	23.50	21.80	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.42	0.72	-3.94	51	469	2012-10-01 21:12:38	2003-04-07 12:59:11	10	12	345	15	283	471	21	103.90	38	21.70	CHANGED	spslVLhVVQssERNhaDQ+hlEhtLhcct.t.IpolRtThs-lpppsplt...............ss..t.....pL.....hlpu..t-VuVVYaRuGYsPsDY..ss.......-s..pWpARLhlEpSpAIKCPolhtpLu	..............................................s.pssllhlVQtsE.RNhaDQ+hl.....Eh...pLhc.......p........t....t.....lps..l..R......hohs-.lt.pp.s.pls.........................................................ss....p..............pL.....hl.s.s........tEVuVVYaRuGYsPsDY...so.........c.p..pWcARlhlEpSpAlKCPolthpLs.............	0	96	155	234
+2828	PF00255	GSHPx		Glutathione peroxidase	Finn RD	anon	Prosite	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.37	0.72	-4.68	12	4817	2012-10-03 14:45:55	2003-04-07 12:59:11	14	11	3035	33	1412	4342	2461	104.50	45	59.73	CHANGED	hY-asshslsG.p.hshspa+GKVlLIVNVAShsGhTs.pYppLptL.c+htspGLsILGFPCNQFGcQEPupscE....lKhhpsst...atssFslFpKl-VNGpstcPlYpaLK	................................hashp.sps.hpG.pshsL..p.p.Y..c..G..K..V..lL..l..V..N.s.A........S.c.......C...G.h.T............s....QY..p...t...L..............p......pLaccY.....p...c....p...G.........h........h.l...L..G........F..P.......C..N...Q.F.s.........t...Q...E..P.G.....o.scE.....................Ipp..aCphs...........a.G.V.o..F.P.hF.sK...l.-VN...Gp....s.s..c....P..LapaL...........................................................	0	446	800	1119
+2829	PF03738	GSP_synth		Glutathionylspermidine synthase preATP-grasp	Bateman A	anon	COG0754	Family	This region contains the Glutathionylspermidine synthase enzymatic activity EC:6.3.1.8. This is the C-terminal region in bienzymes such as Swiss:P43675. Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the biosynthesis of the antioxidant metabolite, trypanothione (N1,N8-bis-(glutathionyl)spermidine), and is a target for drug design [1]. This region, the pre-ATP grasp region, probably carries the substrate-binding site [2].	22.40	22.40	22.50	22.40	21.40	22.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.42	0.72	-3.73	159	2307	2012-10-01 21:12:38	2003-04-07 12:59:11	9	6	1331	17	262	1223	27	99.70	35	22.57	CHANGED	tl.aFssh....ssshEDttTs..taLpcsAppA.............Ghp.sthls.lc-.lshs.............t..pGth.hDh-s...p.lchlFK.LYPWEhhhc-.......................p...hustl..thtp......sthlEPsWphlhS	...............lahsss..c-shEDcsTs..pYL.p-sAppA.............Ghp...ocalhl--.lGhs....................t...tGph..s.......Dh..-s........plIpslFK.LYPWEahhc-..........................c.......hsshLhtp..t.............sthlEPhWpsIlS................................................	0	56	147	206
+2830	PF00437	T2SE	GSPII_E;	Type II/IV secretion system protein	Finn RD, Bateman A	anon	Prosite & Pfam-B_2215 (Release 8.0)	Family	This family contains both type II and type IV Swiss:P54907 pathway secretion proteins from bacteria. Swiss:P07169 VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection [1]. 	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.85	0.70	-5.50	23	13216	2012-10-05 12:31:08	2003-04-07 12:59:11	15	70	4434	45	3599	12796	4731	263.40	26	60.45	CHANGED	tthhhcsl..ctssoDIhlps.tc.lhl..Rlsu...hlpplhp.stptsttllpRltshuph-IuE++...Ducls.......suhchclsh.Psshu..tp..lslR..cpsstth..sLpcLuhssshp.................................pthtchLcps...+s.ILVoGsTGSGKTThL...AhLstlssp..pcpIlTlEDssElpl.puhsplplps+.......sslThschLRuhLR.cPDhIhlGElRDtEshcl.lpAspTGH.s.loTLHsNSAhuAlpRLpphu........ls.h.lps.ltsl..ls.+LsRph	.....................................................................................................................................................hh......h...p....ts...oDl.h..l.....p....s..............t...........p...hhl.....+hst...............h.h..t..h....................h......s.......p...........h..t....t....l.......h.t....p.....l....t.....h...h.....s.....t.....h..............p.....l.....s.....-......p.........p..................-..u.....p..ht..........................pshch......+.l.s..h....h.s....t.ths...........p............hs...l.R............ph..s...t.t.hh.....sl.p.p..L..s..h......s...............................................................................t.t..h...t.p..h...l...p..p...s..................p.....G.....h.l...L.l..o..GsTGSGKT.T.o.L.......t.u.h..l..s.....h...l.....sps...........tp.......+.I.....l....T....l....E.......D....P...l...E.....h.......h......p........t........h.....p.......p.....l...p..lppc........................ssh...o...a...s...s...s...L+..u.s....L.R....p.c....P..D..l.I....llGE.l..R.D.t.......E..T.h.ch.slp.A.u.p...T...G...H..h..l...h..o..TL...Hs.s...s.utp.s....l.s.R..L..h...s..hs.............ht..........l...p.p...t.l..t..t..s........hs...pl...h...............................................................................................	0	1167	2366	3072
+2831	PF05157	T2SE_Nter	GSPII_E_N;	Type II secretion system (T2SS), protein E, N-terminal domain	Yeats C, Desvaux M	anon	Yeats C	Domain	This domain is found at the N-terminus of members of the Type II secretion system protein E. Proteins in this subfamily are typically involved in Type 4 pilus biogenesis (eg Swiss:Q9X4G8), though some are involved in other processes; for instance aggregation in Myxococcus xanthus (Swiss:Q9RF11) [1]. The structure of this domain is now known [2,3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.07	0.72	-4.01	110	3482	2009-01-15 18:05:59	2003-04-07 12:59:11	10	45	1888	2	1060	2838	803	107.90	18	19.45	CHANGED	Llp........Ghhs..........................................p......pp.............................lhpsLucp.............................hslsh........lshpshphs.p..hhth.....lshshhpctthlPlp..hc.s......splhl..AhscP...hs.hphh-plphh.hth.plp..hhlsspsplp.phlpch....hspptst	.............................................................................................................thls..........................................tpp..........................................lhphlut.............................................................hshsh..................hs.l.p..t..h...t..h..s..t....hhth.........hstphsp+apslP.lp.....tp..s........................sp..lhl...A...hsDP..hs.htsl.-.s.lpht.sst..plc........hslsscpplp.ptlpchht.....p.........................................	1	361	719	946
+2832	PF00482	T2SF	GSPII_F;	Type II secretion system (T2SS), protein F	Finn RD, Yeats C, Desvaux M	anon	Prosite	Domain	The original family covered both the regions found by the current model. The splitting of the family has allowed the related FlaJ_arch (archaeal FlaJ family) to be merged with it. Proteins with this domain in form a platform for the machiney of the Type II secretion system, as well as the Type 4 pili and the archaeal flagella [1]. This domain seems to show some similarity to PF00664 but this may just be due to similarities in the TM helices (personal obs: C Yeats).	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.29	0.71	-4.21	340	14010	2009-09-11 10:25:30	2003-04-07 12:59:11	18	9	3954	8	3638	10916	2531	123.70	19	56.05	CHANGED	hhcplushlp.uGlslhpulp..hlspptt..........pthhpptlppltpplptGt...sh..s...puhp................phs.....hh.sthhhthlpsu-puGsLsphLpphuphhcpphphp....hchhsshhtPh......hhlhluhhlhhhllshl.ls	..............................................hcpLuhhlp.uGl.slhpulp....hlsppht........................sthhpp.h.l.p.p..l..tp..p.l.....p.p.Gt.......sl.......s......pulp....................................phs......hF..sshh...ht....h.l.t.sG....E....p.....u.G.p.....L..s.....ph...Lp...pluphhcpphphp...........tc...hhts..h..h.Ph...........lllhl.uhhlhh.hllshllP..................................................	0	1183	2343	3069
+2833	PF00263	Secretin	Bac_GSPproteins; GSPII_III; Secretin; Secretin_C; 	Bacterial type II and III secretion system protein	Finn RD	anon	Prosite	Family	\N	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.74	0.71	-4.86	155	5833	2009-01-15 18:05:59	2003-04-07 12:59:11	16	82	2114	0	1392	4693	1363	161.40	27	28.57	CHANGED	ALppsupsclLusPplhshss......ppAplp.lGpplshh....sspss........ssss.........................hp..hp...........................ssGlpLp.lsP........plss.ssp...lpLplp..phoshss..t..............................................sssPs.....lsp.+plsT.plhlcsGpTlllGGllpcppppspspVP....hLu-IP....llGt.LF+spspppp+sELllhlTPcl...lp	..........................................................................................ALpppupspllu.sPp.lhshss.......................ppA.lp.sG..p.p.lPh.h..........ps.............................s.ss.ss.............................lp....hp.................................................................................................................ps..GltLc.V.s.P................pltp...ssp............lpL.p.lp...phus.hsp..stp..........................................................................................stsss....lsp..+plsT.....pVt.l.p.sGp.o.lllGGlhpcp.ppp..shsp....l.P.....hL.GD.IP........llGt....LF+pp.sp..p.pp+ppLllhlpPpll.......................................	0	408	827	1132
+2834	PF01203	T2SN	T2SP_N; GSPII_N;	Type II secretion system (T2SS), protein N	Finn RD, Bateman A, Desvaux M	anon	Prosite	Family	Members of the T2SN family are involved in the Type II protein secretion system. The precise function of these proteins is unknown.	26.00	26.00	26.10	26.60	25.80	25.80	hmmbuild  --amino -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.42	0.70	-4.77	42	400	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	393	0	109	339	61	211.50	25	84.42	CHANGED	hslsps.lslsulsGolWpGpspplphp...sh.pls.pVpWslsshuLltGpsphslphup....tt.slpG.pG.l.shuhu.uhtspslphshssshlhphh....hshPlps....sGplpl.....tlppht.....upshCppl.pGplhhp.suslpsshGsl.sLG.sltusluCp.s.uplhsphppsssplslshpsplp..sstpaphsuplc.sssshPsslppsLshlGps.cs...pGtashphpGRl	..................................t.lplssspGolWpGp.A..s.l.thp...................sh...h.....G..plpWchphh....sLlhGphphclchsp.......tlpu.tuhl....shuh.s..uhhspshthslPuu.hlhshh.........hPh.s.lph..pGplpl..........slpphp.......hups.hspph.pGplhhp..tspl....p....usl....u....s....l....sLG....sltusls...sp..s..uslslpl.....sp...p..s.st...lt.hphphslt....sss..paphpuhhp..s...tsp.s....t...s....Ltt.LshLGps.su...pGt.h.h....................................................................	0	28	57	83
+2835	PF03958	Secretin_N	NolW-like; GSPII_III_N; 	Bacterial type II/III secretion system short domain	Yeats C	anon	Yeats C	Domain	This is a short, often repeated, domain found in bacterial type II/III secretory system proteins.\	\	\	\	\	   All previous NolW-like domains fall into this family.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.50	0.72	-3.80	231	6199	2009-01-15 18:05:59	2003-04-07 12:59:11	12	49	1721	11	1290	4691	1113	81.90	24	21.96	CHANGED	spll.Lphssus-...............lsshLpph.h..................................................................................stph.pltssspsNslllp.ussptlpplpp.llpplDhsttp	..............................................................................................................pll.LpausAp-...................................ls.plLppl.h................................................................................................................................................ss.ps..plssD..pc.oNslllp.ssssshpplpp.lIppLDh..t.....................................	0	370	706	1018
+2836	PF02501	T2SI	GSPII_IJ;	Type II secretion system (T2SS), protein I	Mian N, Bateman A, Desvaux M	anon	Pfam-B_2607 (release 5.4)	Domain	The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. As members of the T2SJ family, members of the T2SI family are pseudopilins containing prepilin signal sequences [1].	25.00	25.00	25.60	25.40	22.90	21.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.50	0.72	-4.01	100	934	2012-10-03 10:38:27	2003-04-07 12:59:11	12	4	817	9	179	576	128	81.20	28	65.20	CHANGED	tLc-+slAtalA-NplsclpLp.pthPshu...tppupsphuGppWhhphp.ltsTsss.p.......hpplclpVt.........spp.pssslspLssalsp	.................Lc-+slAsWlA-Nphspl....pLt...pth.pss.........pppGpsphuGppWaW+pp..shsT...sss.h........lptl-lpVs........ppctsssltphpuhh..................................	0	34	83	132
+2837	PF03934	T2SK	GspK;	Type II secretion system (T2SS), protein K	Bateman A, Desvaux M	anon	COG3156	Family	Members of this family are involved in the Type II protein secretion system. The T2SK family includes proteins such as ExeK, PulK, OutX  and XcpX.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.75	0.70	-5.24	106	1236	2012-10-03 02:11:09	2003-04-07 12:59:11	8	4	993	1	289	1639	405	262.20	26	82.09	CHANGED	c.phphcpspshhttpQAhahuhuupshActlLppsh................hspLsph.WA...ts..h.hsl-.....................p.GplsuplpDhpupFNLNsL...............................stsst.................................hpshshptappLLpsLuls......t.tupplscslhDalDsD............................pt..t..GuE-s.Y..tutsssahs.usp.hssluELphl.Ghosphhp+LtPalssLP......s..pthlNlNTh....sA.lLsAlhss.....lshspAppllpp..........R..sts.sap..sls-ahst............lss.......t.....hpstls...lsSpaFtlpup....sphspsphphpollpps...............s.ssshs.l	......................................................................................t.phtpsps..phtQAhahuhu..u..p.p.hAh.t.h.Lppshpppt.................hspLsp....WA............ts....t....h....ls...................................................................p..up..l..psplpDtpupF.N..LNsL......................................ht..s.....................................pshshphhptLl..t.p....l...s.ls...............thpuctl..spul.h-alDp.D..................................pps...t.hhG.s.EDs.Y.....ut.s.ssahs...usp............htsluE...L+hl.p..Ghs...s..........t.l....h..........p.......+.........L..tPhV....s........s........LP...........sphpl.NlNTh...............pu...lLtAlh.s......lo....s.pA..ptllpp...................R..........stp..sat....s.hsph.htt............................lss............htt............hpshls..l.p.Sp.aF..lpsp....hhh.sp.p.hp.hpoll.t.t.p.....hh...............................................................................................................	0	83	161	229
+2838	PF05134	T2SL	GspL;	Type II secretion system (T2SS), protein L	Moxon SJ, Bateman A, Desvaux M	anon	Pfam-B_6494 (release 7.7)	Family	This family consists of Type II secretion system protein L sequences from several Gram-negative (diderm) bacteria. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. T2SL is predicted to contain a large cytoplasmic domain represented by this family and has been shown to interact with the autophosphorylating cytoplasmic membrane protein T2SE. It is thought that the tri-molecular complex of T2SL, T2SE (Pfam:PF00437) and T2SM (Pfam:PF04612) might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation [1].	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.33	0.70	-5.18	19	962	2012-10-02 23:34:14	2003-04-07 12:59:11	8	5	829	4	181	775	109	221.90	22	57.66	CHANGED	Lhl+Lsssstpshph......hpstttphhtpG....phsstpshspls.hssts.shlllPusslhhpplsLPstst+phhpsLPahLE-plApDl-plHhslh.............stps-.ptpVssVc+phhptWLshhpptGlssppllPDshsLPh..sssuhsshphss..................................................pWLlRpstttGhus-tphhshhhtt...........ltshsssPt.s.s...........htsts.pshhhlhApshht...sshsLhpGtFs.p	.....................................................................t...t..h...W...................tt....htpG.............hss..s.....p...p.L..tt....h.........t.....t...ts...lhl..l..lPuptlh.hhplpLP......s.......h....t...t.........+..........p...h...ph.Lsh.l.lE-plsp..D..l-p..l..H..h...slh.........................st..p.tp....ts....pV.s..s.l.c..p..phhcphlphLpts.Gl.sh.spl.........hP.........D....h........h....s.....l.Ph........t.tuhs..s.h.p.h.t.t...........................................................................phlh.Rts...tt...p......Gh...u..h......s..h.......s.hh.sh..h..ht.t...hspt..................ltshs..s.Pt..h.s....................................httt.s......tt...........h.......h.....hh.t....hht....sphsLhpG.ap......................................................................................................................................................................................................................	1	37	88	134
+2839	PF04612	T2SM	GspM;	Type II secretion system (T2SS), protein M	Mifsud W, Desvaux M	anon	Pfam-B_5302 (release 7.5)	Family	This family of membrane proteins consists of Type II secretion system protein M sequences from several Gram-negative (diderm) bacteria. The precise function of these proteins is unknown, though in Vibrio cholerae, the T2SM (EpsM) protein interacts with the T2SL (EpsL) protein, and also forms homodimers [1].	25.90	25.90	25.90	26.00	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.74	0.71	-4.44	63	1099	2012-10-02 17:03:51	2003-04-07 12:59:11	7	7	852	2	233	747	121	149.60	22	84.64	CHANGED	hpplpthWpshssREppllsshushLhlslhYhslhpPhppttppspppltptppplshlpppusphpthp.ssssssstst.........uLpsllspoupptGl....slpRhpspGc.plpVtlcsssFssllsWLspLppppGlplpphclsct..............ssGhVslphhh..tts	........................h...lppaatshosRE+thlhssushlhsshhah....h..l....hpPh....ppphpp...t...ppplpphpp.hshlpspAs.plt...shp...tts..ss...pst...................tlspllsposp.tts.l............sl.t.p...lt....p.........u.........c................p........lplhlp.sssasslhpWLstl.p..t.p.h.u..l.plpphpls.tst.............tsG.lplpth.....s.........................................................................	0	63	127	185
+2840	PF00043	GST_C	gluts; GST;	Glutathione S-transferase, C-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants.  Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity.\	\	\	\	The glutathione molecule binds in a cleft between N and  C-terminal domains. The catalytically important residues are proposed  to reside in the N-terminal domain [1]. In plants, GSTs are encoded by  a large gene family (48 GST genes in Arabidopsis) and can be divided  into the phi, tau, theta, zeta, and lambda classes [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.00	0.72	-4.00	58	13485	2012-10-03 01:14:49	2003-04-07 12:59:11	20	103	2532	701	4893	16003	4903	96.70	16	41.41	CHANGED	hhshthphhhhshtts................................pppc.thppsppclhchlphhpphLp......sppah.sG-phohADl..hhhshlt...hhhthphshh.........spaPpLpsahp+lhsps	........................................................................................................................hh................................................................t.........h...t...t.....h..h..p....p.....h...p....c....h.....h..p.h....l....-pt.Lt.............ppsa..l....s.......G......-.....p...h.olA....Dl......s...h.....h...sh..lt............hh.....t...t..h.t..h.s.h....................sphP.p.lptahpclttps.........................................................	1	1323	2464	3783
+2841	PF02798	GST_N	gluts; 	Glutathione S-transferase, N-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington	Domain	Function: conjugation of reduced glutathione to a variety of  targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST  activity; similarity not previously recognised. * HSP26 family of stress-related proteins. including auxin-regulated  proteins in plants and stringent starvation proteins in E. coli.  Not known to have GST activity. Similarity not previously recognised. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.47	0.72	-3.80	53	5748	2012-10-03 14:45:55	2003-04-07 12:59:11	15	61	1695	674	2420	16335	5075	72.80	24	29.98	CHANGED	hslphashps..tspthRhhLt...htGlpaEt..phhsh....t.....spahphpst...............splPhl.ps......shplspShAIhcYluc	......................................................ha...h.s......ts.t.h.t..h..h.Lp......thG..l...p.....a...-..h.............h..h...l..........s..h..........t...t.....t....p....ht.......sc.a.h..p..h..p.Ph..........................upl..P......sl...p...cs................sht...lh...E.......S.s..A.IhpYLu.....................................................................	0	799	1279	1900
+2842	PF00735	Septin	GTP_CDC; 	Septin	Bateman A	anon	Pfam-B_440 (release 2.1)	Family	Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin.  Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerise to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis [2].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.72	0.70	-5.39	14	2609	2012-10-05 12:31:08	2003-04-07 12:59:11	13	25	286	15	1492	3139	269	234.50	37	62.73	CHANGED	+GhsFTLMVlGcSGLGKoThlNoLFtosLhss.....................pth.tst-.ctcpTlcIc.tpps.lEEc.Gl+LpLoVlDTPGFGDslsN.spsWcsllcYI-cQa-pYLcpEsplpR.pphhDsRVHsCLYFIsPsGHGL+PLDlthMKpLpp+VNllPVIAKADoLTscElpphKppIhp-IcppsIcIap..Pss-ps-..........-E-.hppscpL+pslPFAllGSsphlEt..cGcpVRGRpYPWGlVEVENssHsDFltLRshLlpTHlpDLp-sTpchhYEsYRocpLpshthtscs	.......................................................................pGhpFslh.s.s...G.po.GlGKSTl....lN...o...L....F.t...o....p..h....t..t................................................................................tp.......php..p.....s.l......p.l.p..........t........p...h....p......l......p....E..p.....s..l...+.....l...p..LT.....ll.D..T.s.G....F....G...D...t...l.....s.s...p..............p.......s....a.p.....s....Ih......c.a..I.-....p....Q..a.....-.....p.....Y........Lp....c.........E...........p.....l.....p.....R.........h.....p.....h.....................D.s..Rl.........Hs..CLY........F.I.s....P..........s....G.......H.u.L+.s.LDl.t..h....M.Kp...L...pp..+.......V..N....l.....l.P...lIA.KADo...lo...p.Ehpph..Kp..p........I.h..p-l.t.......p.ps....l..p...........l..Yp......s..t.....p..p.-p..............................................t.....h......p.....stp.....h...p.t....h............P.FAV..lGSp..p....h..p...........h.........t.......s.....+.......h.....l....+....uRpY...s..W.G.h...l.p...V...EN.......p.HsDFhhLRp..h.Ll...p.s.php...DLp-.TpphaYE.taRt.ppLttht.....tst.............................................................................................................................................	4	422	705	1111
+2843	PF00925	GTP_cyclohydro2		GTP cyclohydrolase II	Bateman A	anon	Pfam-B_1147 (release 3.0)	Family	GTP cyclohydrolase II catalyses the first committed step in the biosynthesis of riboflavin.	23.20	23.20	23.60	23.20	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.07	0.71	-5.01	161	5362	2009-09-11 05:22:16	2003-04-07 12:59:11	15	28	3848	3	1428	3867	2940	160.90	39	47.23	CHANGED	lcchspsplsTpa.....G...pFchhsac....sthssppH...lALlpG.......ch.s.sspssLVRlHupshsuDlhuoh...ps-sutpLcpAhctIuc..................................p.Gt.....GVllaL.t...pcucuhuLh...s+lpshthp.cp.uhcshcss..............DhRsY.uluAQILpcLGlp......cl.+LLoNsP.c.KhtuLpuaG..lcVsppl.sh	....................................................................................................phhspsplPTta.....G.....pFphhuac..................s...h..h..s.........s.....p...c.H....................lALlhG.................................................sh....s....s......p....ps..lLlRlHS.EClTGDlhtSh........RC.D...C...G.........QL....c....tAhp....t....I....sc...................................c..Gp....GlllYL.c....QEG..R.G..I..GLh...sKl+...A...Y...t....LQ...-p....GhD....T....l....-....A....N.htLG.h.....................ssDhR.-a.s.luA.pIL+.p.LGlp............cl.RLLT....N...N..P...c..Khpu..Lp..sa.G....lpls-cls........................................	0	444	916	1213
+2844	PF01227	GTP_cyclohydroI	GTP_cyclohydro_I; 	GTP cyclohydrolase I	Finn RD, Bateman A	anon	Prosite	Domain	This family includes GTP cyclohydrolase enzymes and a family of related bacterial proteins including Swiss:Q46920.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.06	0.71	-4.99	104	4297	2012-10-01 20:59:24	2003-04-07 12:59:11	17	9	3743	160	1127	2999	2646	175.90	44	84.59	CHANGED	hcpul+plL.pslGEDPsREGLh-.TPcRVA+ha.pElasG.hppss....phl.......sphFp.....................hs-h..Vll+cIphhShCEHHhlPFhG.pAHlAYl.P..s.s+VlGLSKlARlV-hau+RhQlQERLTtQIAsslpch.LpPcGVuVll-AcHhCMshR.GVc+ssupThToshpGhFcs-spsRpEFhsllp	........................................h.ptsh+plL.ptl.G..E...Ds..s...R-.GL.h-.T.PpRlA+hY...pElF..u..G.hptss........tplh..........ss.h.Fc..........t.................................h-EMVlV+DIs...haShCEHHhlPFhG......+AHVAYI.P....s..s+V......lG....L..SK..luR.....lV-haA+R.......Q...lQERLTpQIApAlt....ch.L..........p....sp.........G.......VuV.ll.EA.pHh.C.Mph..R..G.Vc.K.sso...tTsTosh..tGh.Fcp.stpsR.pEFLphl.t..........................................	1	354	686	946
+2845	PF04670	Gtr1_RagA		Gtr1/RagA G protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4577 (release 7.5)	Family	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1.\	\	\	     Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family.       The RagA/B proteins are the human homologues of Gtr1.     Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.53	0.70	-5.22	32	723	2012-10-05 12:31:08	2003-04-07 12:59:11	7	10	282	7	491	12357	922	216.90	39	64.20	CHANGED	KlLLMGhptSGKoSh+pllFsNh.sp-ThpLusTl............................cl-pspl+.hutl..slslWDhsGQpsah-s...hhttpp-pIFpsVt......sLlaVh.Dsp........................p..-...htcsltpappslptlhphsPst+laVLlHKhDhlp...c-hRp-hacchtpclpcpsp.........sht.t.................................lshahTSIaDcSLYcAaSpIVppLI.PphsslEphLpphsptsss-clhLF-psohLhlupsstp.sc....t.............................paEphSshI	................................................................................................................+lLLMGhp.tSGKo.........S.......h........p.....p....l......l.............F.........p............p.....h..........s.....p........-....T........h......h.........L.....t...u........T..............................................................c..l...p....+...s.....c...l...p....................u.........l............sh..p.l.W..............Dh.s..G......Q...........s....F.....h..-s.............h............p......p..-...pI...F..p....s....l.s................s.LI..a.V..h..Dsp...................................................c......-.......h..c..s.l..p.p.h...p......p..s...l.....p..t......h.....h.....p......h.....s.......P........s....h.....p........l........l...h...l....H...KhD.....h.....lp..............-.D.....p....+......c..h.........c....-.......h....p...p...c.....l.p....cp...t........shs...........................................................................................ls.h.ahT..S.I.....a.D........c.S....l.a.c.A..a.......Spl...V...pp..L..I...P..plssLEshLp.hsp.....................ph-c...sh...............LF-hsohl..hIusss.p.s..c........hp..........................................paEhhSshI.............................................................................................................................................	1	177	261	390
+2846	PF04138	GtrA		GtrA-like protein	Kerrison ND, Finn RD	anon	COG2246	Family	Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans.  They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans.  It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation.  Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane [1]. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyses the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b)[2]. This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains.  Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose [3].	21.30	21.30	21.40	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.75	0.71	-4.14	175	4541	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	2742	0	1077	3355	691	115.20	18	65.05	CHANGED	+F.sllGshushls....hsl...hhlLh...h...............hthshhlAssluahsuhlhsahhNchaoFcspppt..........htphhpFhhs.shhuhhlshsh...hhlhh.phhth..........h..................................upll...uhhlsh.l...hsalhs+halF	.............................ahhhGs.hss.lls...hsl....hhlhh...h...........................hth.p.h.h....lA..s....hl.uhl...luhlhsahhNc...tasF.cspspt.................hpph..h..p..Fhhh..thh....sh.hl.s....hh.l........hh.hhh...ph...h.sh..............hh......................................................................uhlh....u.hlsh.h....hsalhp+hhlF.......................................................	1	357	710	932
+2847	PF00211	Guanylate_cyc	guanylate_cyc; 	Adenylate and Guanylate cyclase catalytic domain	Finn RD	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.96	0.71	-4.93	21	9831	2012-10-01 23:51:22	2003-04-07 12:59:11	15	564	1435	89	5200	9161	3221	176.30	23	25.87	CHANGED	lhsppacsVolhFuDIsGFTshsspps....shpllphLN-laspFDcLhsppt...lhKlKTIGDsYMssuGls....................cst.tHstphschALshhcth.pshshpp................................pslplRlGlHsGsVluGVlG..h+pscYslaGsTVNlASRMESsGhsscIpl..oppshphLp.......taths.c.uchpl+........G....+............uphpTaalhu	...............................................................................................................................................................h......ppl..sl..h.F.u.............D.l..h.u.....F...T.p..h.sp..phs........................st...p.ll..p.h.L...sc.h.h.......s........t.h.s...p..l.l.p.php............................shh....l......K..h...l................G..D......u......h..h..ss..h..Ghs....................................................................p...p..s...t..p...ss...p.........h..u...l....s....h....h..ct...h....p...p...h.p...hpp.....................................................................................................................s..l....p..l....R....l....G..l..p......s............G.........................l.l...s.....G..s.l......G................p..........p...........p.....a..s....l.h.Gs.s.V......N..........hAu.....R.h....-..u..h.....u..........t...............s.......s................p......l..h..l.......o...p....p.s.h.p.h.lp..................th..t....h..p...h....s....h...l+...................G....................t..........t.....................................................................	0	1996	2930	4185
+2848	PF00625	Guanylate_kin		Guanylate kinase	Bateman A	anon	Bateman A	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.98	0.71	-4.84	12	8050	2012-10-05 12:31:08	2003-04-07 12:59:11	16	166	4712	73	2497	6019	2540	171.00	31	44.42	CHANGED	pt+slllhGPSGsG...+splhpsLlsphscpF.u.hsVs+TTRs.R.sEhpGccYaFl.o+-phppsIppstFlEaup.asushYGTphpslcplhcpu+p...slLDl-.hQusppl+ps.phsPhhlFItsPShpslpch.cthsppstcpltcchsthcpphpph.....FDhllsNssl-cshpcLcchlpst	........................................h...h.lll....s...GPS.Gs.G..............Ksolh.ptL..hp.p.....s.......p........h....t...hSl.S........t................T.TRt........R....u...Eh....c..G......h...c..Y.....a.Fl..oc.-p.F.cp..hl......p......p.s.p..h....l..E.......a...........u....p....h.......h..............u....N...............h........Y..G..T...s.h.p...tl..c..p.h.h.p...p...G..ps...................llL-.l-...hp.........G....s...p.p..l.....+.....p..............p......h...................p........s......h......h....lFl..t..P............P......S.......h............c..............p...........L........c...............p..........R..............l.............t............t............R...............u.............p......-...........s...t....c.....h....l........t...p...........R........h......t......p..A...p.....p..E..h.....p...t..h.....p.........aD..h.l.l....l.N..-..s...l.c....p.A....hpclppllt..........................................................................................................................	1	729	1238	1842
+2849	PF02058	Guanylin		Guanylin precursor	Mian N, Bateman A	anon	IPR000879	Family	\N	25.00	25.00	68.30	68.00	18.60	18.60	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.42	0.72	-3.91	15	87	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	40	5	38	70	0	89.50	45	80.48	CHANGED	puVpVp-ssFoFsLESVKKLK-Lp-......spoPRLtpps..........ssslC.spPsLPp-LpPlCpppsAusIlpRLcsIus..DsCEICs.sACTGC	.........uVhlQ.tsFphpLESVKKLc-Lp-t.....h.sPRltsps...........hPslC.spPsLPp-LpPlCppppAupIhppLcsIAp..csCElCs.sACTGC............	0	2	2	7
+2850	PF05120	GvpG		Gas vesicle protein G 	Yeats C	anon	Yeats C	Domain	These proteins are involved in the formation of gas vesicles ([1]).	27.30	27.30	27.50	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.57	0.72	-4.17	11	122	2009-09-12 20:43:27	2003-04-07 12:59:11	7	2	104	0	50	138	7	76.20	33	85.04	CHANGED	LLplsh.uPlpGllWIu-plpEcA.-pphpD.psLpppLssLphpL-hG-IsEEpF-pcE-ELL.+Lcthtp...htttstttss	.......lhhlsh.uPlcGlhWlu-plp-pA.-cEhh.Dsssl+pcLtpLptth-tGEIoEEEa-ppE-cLLpRLpthtt............st.............	0	19	40	49
+2851	PF05121	GvpK		Gas vesicle protein K  	Yeats C	anon	Yeats C	Domain	These proteins are involved in the formation of gas vesicles ([1]).	25.00	25.00	36.70	31.80	21.30	19.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.75	0.72	-4.16	19	150	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	127	0	62	157	6	87.20	46	75.27	CHANGED	pht......l-s.sscslptGLssLVLTVVELLRQLMEpQAlRRMEpGsLS-splERlGpsL.tLE-pltcLpppaslssp..DLNlDLG.lGsLLsp	.....s.plsh-s-slcpsLspLVLTlVELLRQLMERQAlRRh-sGsLo--QlERlGp.oLMtL-cchp-Lp-paGlpsc..DLNlDLGPLGsLL..................	0	22	49	60
+2852	PF02213	GYF		GYF domain	SMART	anon	Alignment kindly provided by SMART	Domain	The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.	20.50	20.50	20.60	20.50	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.04	0.72	-4.38	79	823	2009-01-15 18:05:59	2003-04-07 12:59:11	11	22	290	12	564	801	13	55.40	30	6.25	CHANGED	hhWhYh....DspuplQGPFsutpMppWhppGYFsssl.l++h........ttsp..pshh.....hpphhtp	...............hWhY+.........DspG.plQ........G.....PFsstpMppWhpsG.YF..s.......s.Lhl++s........pptph.pshh....ph...t................................	0	187	316	466
+2853	PF02895	H-kinase_dim		Signal transducing histidine kinase, homodimeric domain	Griffiths-Jones SR	anon	Structural domain	Domain	This helical bundle domain is the homodimer interface  of the signal transducing histidine kinase family.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.16	0.72	-3.64	148	3074	2009-01-15 18:05:59	2003-04-07 12:59:11	9	46	2055	3	891	2655	208	69.70	34	8.88	CHANGED	spol.RVcsp+LDpLhNLVGELVIscspLtp..hspphp..................................................................pp..........lppshppls....+...........l.sp-LQ-slhph	....................pol.RVsl-+lDpLhNLVGELVIsputLsp..hup.p.hs........................................................................................................................ppc......................Ltp.shspLp...........c.................................................lsp-LQ-uVMph........................................................................................................................	0	298	603	761
+2854	PF03030	H_PPase		Inorganic H+ pyrophosphatase	Griffiths-Jones SR	anon	Pfam-B_1050 (release 6.4)	Family	The H+ pyrophosphatase is an transmembrane proton pump involved in establishing the H+ electrochemical potential difference between the vacuole lumen and the cell cytosol. Vacuolar-type H(+)-translocating inorganic pyrophosphatases have long been considered to be restricted to plants and to a few species of photo-trophic bacteria. However, in recent investigations, these pyrophosphatases have been found in organisms as disparate as thermophilic Archaea and parasitic protists [1].	22.20	22.20	22.40	22.40	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	682	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.86	0.70	-6.27	139	1540	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	1217	2	611	1460	5022	626.60	43	93.38	CHANGED	ulluLlauhhhhttlhptssGs......................................................................................................................................pcMp-IussIp-GAtAaLp+QY+slulhslll..slll....hhh............................................................uhhsuluFllGAlhSuhAGalGMplus+ANlRTApAA................pptu.............hspALplAF+uGuVhGhhVlGLuLLGluhhahlh..t.......................tthhpslsGauhGAShlAlFARlGGGIaTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDsAGMuADLF.ESYssollAshlL...ushhhsst...................hlhaPLl.luulGIlsSllGsahV+sppss....................................................................................................shhpALppGhhloullshlshhhlsthhh........................................t.st...........h.....tlahsslhGLlsuhlIshlTEYYTussapPV+cIAcu.SpTGsATNIIsGLulGhcSTshPlllIssuIhsuahlu........................GLYGlAlAAsGMLossGhslAlDAYGPloDNAGGIAEMu.tLspcVRphTDtL....................DAVGNTTtAlsKGaAIGSAuLsALsLFuuYsppl............................................................................................................sh..hsl..sltsPhVllGLllGuhlPaLFuuhsMpAVG+AAtphVpEVRRQF+-hPGIh..........................-Gp..s+PDYs+sV-IsTpuAl+EMlhPulLsllsPlllGhl..lG............s.............puLuGhLhGslloGlhhAlhMuNuGGAWDNAKKYIE.........sG..ph.G.G....KGS-A.....HKAAVlGDTVGDPaKDTuGPulN.LIKlhslluLlhs	..................................................................................................................llul.hauhh.hht.lht...s......Gs..................................................................................................................................tcMp-IuttIp-GA.uaLtppYphlslhhlllhlll....hhh.h......................................................shhssl.uFllGAhhSshuGalGMplushANsRTAtAA..................................p..u.............hstuhplAF+uGulhGhhlsuluLLslshhhhlh.......................................t..h.hpslhGauhG.uS.lAlFuRlGGGIaTKuADVGADLVGKV........E.tGIPE..DDP......RNP..AsIADNVGDN..VG....DsAGMuADLF.EoY..s..sohl...........Ashsl...ush..hhh..st..s.........................hhhaPlllsu.h.ulls.Sl.l.Ghh.h.lp.s.t.t.s.s....................................................................................................sh.tuLppuhhlo...ullshlshhhhshhhh.....................................sth.............tlhhsslhGlls.uhlIshlTE.....YYTusshp.............PVpplApu.u.p.T.GsuTslI.tGLulGhpSshhPslhIssuIhsu.ahhu................................GlaG.lAlAA....hGMLuhsuhhlAlDAYGPlsDNAGGIAEM.u......t..l.s.......p.........c...........V.RchTD.tL....................DAlGNT..TtAlsKGaAIGSAuLsAL.sLFuuYhppl..........................................................................................................................................th.....hsl.........slhsPhVllGLh.lGu.hlPalFuuhsMp.AVG+AAhphVpEVRRQF+-hPGIh..........................c..G...p...s..+PD.Ys.+sVcIsTcuAl.+EMlh..Pu.lL.........sllsP...lll.Gh.h..hG.................................stuluGhLhGsllo.G.........lh.hAI.h..uNuGGAWDNAKKhlE..........t.G......th..s...u............................KGS-sH.KAuVsGDTVGDPaKDTuGPulN.LIKlhslluLlh.....................................................................................................................................................................................	0	268	465	553
+2855	PF01725	Ham1p_like		Ham1 family	Bashton M, Bateman A	anon	Pfam-B_2030 (release 4.1)	Domain	This family consists of the HAM1 protein Swiss:P47119 and hypothetical archaeal bacterial and C. elegans proteins. HAM1 controls 6-N-hydroxylaminopurine (HAP) sensitivity and mutagenesis in S. cerevisiae Swiss:P47119 [1]. The HAM1 protein protects the cell from HAP, either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions [1].	19.60	19.60	19.90	19.70	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.10	0.71	-4.93	110	5049	2009-01-15 18:05:59	2003-04-07 12:59:11	11	23	4640	36	1328	3692	2890	187.30	39	82.95	CHANGED	lllATsNptKlcEhpplLsshs....hth............tclt....th.h-l.Es.usoat-NAhhKActhsphh............sts..................sluDDSGLpl-ALsG...hPGlYSARa................u.......................cpt..s.pt....LLch..lpsh.....cs........RsApFhssluhsp..sssp...........hhh................hcGpsc..GpIspps+..Gps.GFGY............DPlFhs.p...sh....spTaAEh...s.cpKN........plSHRu+Alpp.....lhph...L	.................................lllATsNtGKlcE..h..pplLsshs.............hcl...hs.............s-hs.......s....-s.tET.........GtTF..tENAhlKActsu.c.h.s............Ghs...................slADDSGLpVD..AL..s.G.....tP..........G.lYSARa.......................................u.................Gpts..........sDpt...N.p+.........LLpp..Lpsh................cc................R.pApF.hsslshsp......ss.sp.............shl..............................................sc.G.ph...p..Gp.......Ih...p...p...s.+...........Gps...GF.........GY............D...Pl...Fhs..s..th..............scThAEL...st-.E..K.s...............tlSHRupAlctLhp..h........................................................................	0	453	851	1131
+2856	PF04388	Hamartin		Hamartin protein	Bateman A	anon	Wood V	Family	This family includes the hamartin protein which is thought to function as a tumour suppressor.  The hamartin protein interacts with the tuberin protein Pfam:PF03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin Pfam:PF03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking [1].	25.90	25.90	26.00	26.00	22.00	25.80	hmmbuild  -o /dev/null HMM SEED	668	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.39	0.70	-5.85	6	205	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	137	0	142	206	0	536.20	25	62.51	CHANGED	pppssls-LlshL-SssLcpl--V+shlpEpLSs-+GshLVNsLVDYaLpTsSppslclLoolpEPHDKaLLDKhNEshs+sssRLsoLoLLGHVVR+QPsWlHKIu+hPLLsSLLKCLKpDoDVVVLhoulLVLITLLPMIPQosKQaLhDaFDIFGRLu...............SWsl..............+sPG+ss-VaLl.......HL+AuVYS.LFHRLYGMYPCNFlSYLR..paYSMKENh-T....FpEVVK...............................PMLp+VRlHPpLVTGTpDaEL.DPoRWKchEsHDlVhECA+lS...............LDsp..EuSsE-Gh.ohsc...........................SsusPhsusp..h.s.stShP..oshphoh+SspTph.spsphD.st..ssc-slWSPSslCGhuTPPSSh.shsP...hplshpsuh.suchhussGuGpspsus.STPuTos.....P...Pshuss..hhph..ssspsps.ppcc.psp.uhshhsRppp.........................lpsl-+psc.................tpthcsulspElhpl...sptp.c..ssh.Ghc.sh.h..cpLhssptpctp...............LsSo.D+....................Gsssspuu.shp..W.....FTPh-ssh+cp..s......c.pt...s..s.usCptsst..........s.PY-th...F-lALPK...susLFlp+KTtEslc+sttpc.p.......phcccslssoS....PhEVLD.clIppGp-AHsc..cR.hs.so.o.c.spht...P...-ELcslRuQLLL....LHsQLLYERaKRpQHAlR..........NRRL	.............................................................................................................................t....................................................................................ppP..p.hhsplsp.hht.p...s...t...pRl.sLpLL.s.phlphpPsah.apl...ptsLh.slL+sL........phDssssslhsullsLlhhLP....hl....P.p....uh..tp....aL...chFslauRLs.........................sWph....................................................................................................................pps.s..ph..sc.hhl..............................HL....ph...u..l.h........t...LFp...hLYGhYPsNFlsaLR........pha....p.h.c..p.....s..h.ps...........hpcs.lc.........................................PhhpphplHPp.l.l...T..s...o..h......-.pEl..cspRW.......pchE..s.......cDlVhECtp.l.s.............................................Lssh.....pss..ppt......t.......................................................................................................................................................s.s.P.h..ts...................p..s...........t.h..p......t.t..................................................................t....h..os...p...............th...ps..s.........s......s.........................s....p........s............p......h...s..t.s..s........p........shsths...................................t............................t..................th..h...tttp..............................................................................................h.......p..................................tt....s.p..tp..th........h............................................t......................................................................................................................................................................................tt...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	47	66	110
+2857	PF01567	Hanta_G1		Hantavirus glycoprotein G1	Bashton M, Bateman A	anon	Pfam-B_399 (release 4.0)	Family	The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA. 	25.00	25.00	46.60	46.00	17.00	16.40	hmmbuild  --amino -o /dev/null HMM SEED	525	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.86	0.70	-6.25	15	433	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	136	1	0	365	0	303.60	52	49.41	CHANGED	+slYEhKlECPHTVsLGQGhVsGpVELs.lPLsclssLhlESSCNFDl..HsossshQpaTpVsWcKKushs-ossAupsoFEspSpEVsLKGTCslsschhEssaKs...RKTVlCYDLSCNQTaCpPTVaLIuPlpTChoh+SChluLuspRIQVlYEKTYCVoGQLlEGpCFsPs+TlshoQPsHTYDlsTlPlhCFhlsKK...GsshKIhsplEp.lhsKssCT-NslQGYYlChlGupSEPlaVPuh-DaRSuElhS+MlhsP+GEDHDhstsupushRIuGPlpuKVPpTpoo-ThpGlA.FuGlPhYSSLSsLlppsDPcYlFSPGllP-tNHSsCDKKTlPLTWoGalslsGphE+lTsCTVFCTLuGPGASCEAYSEsGIFNISSPTCLVNKsQRFRGoEQplNFVCQRVD.DlVVYCNGQKKVILTKTLVIGQCIYTFTSLFSLlPGVAHSLAVELCVPGlHGWATsALLlTFCFGWlLIPulTLllLKlL+llsa.CS+YosESKFKhILEKVKhEYQKTMGS	.....+sl.-h+hpCPHols..hGps.l.G.sEls.h.lttstphh.ESSCshD...Hpohss.pphTpl.WctKu...pptpuspsoFps.ptplsh+GhChl..phh-psh+.s...++olhCYDLsCNpThCpPTlahIsPl.sC...c.Ch...........................................................................................................................................................................................................................................................................................sl.haCNG.+KhIhT+TLlIGQCIYohTSlFSlhPuVAHSlAlELCVPGhHGWAThhLlhTFCFGWlLIPshThhlLhhLhhhs..hpp.s.-pph+.llp..............	0	0	0	0
+2858	PF01561	Hanta_G2		Hantavirus glycoprotein G2	Bateman A	anon	Pfam-B_401 (release 4.0)	Family	The medium (M) genome segment of hantaviruses (family Bunyaviridae) encodes the two virion glycoproteins. G1 and G2, as a precursor protein in the complementary sense RNA. 	19.30	19.30	20.30	19.30	17.70	19.20	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.75	0.70	-6.09	6	1286	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	278	0	1	760	0	186.40	42	58.72	CHANGED	shsLpPsWoDsAHGVGllPM+TDLELDFSLPSSSpYTYRRcLpNPsNEppplsFHlpI-cQsItA-IQpLGHWhDupaNLKTuFHCYGACpKYtYPWpTAKCahEKDYEYETuWGCNPsDCPGVGTGCTACGlYLDKLKSVGpsaKIISl+YoR+VClQLGsEppCKpIDsNDCLlTsuVKVClIGTlSKFpsGDTLLFLGPLEtGGlIFKpWCToTCpFGDPGDIMSTpsG.hpCPEasGuFRKKCsFATTPlCEYDGNTlSGYpRhlAT+DSFQSFNsT-PHlTss+LEWhDPDuoLRDHINllls+DlsFpsLuENPC+VsLpsuSIDGAWGSGVGFoLsCpVSLTECsoFLTSIKACDpAMCYGAoossLsRGQNTV+IsGKGGHSGSpFpCCHsp-CSppGLpAuAPHLDRVsGhsplDs-KVaDDGAPECGlpCWFpKSGEWlhGILsGNWlVlsVLlVlLILSIhLhSlhCPsR.p+KKu	........................................................................h.............................ChGtC.c.th......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1	1	1
+2859	PF00846	Hanta_nucleocap		Hantavirus nucleocapsid protein	Bateman A	anon	Pfam-B_310 (release 3.0)	Family	\N	21.40	21.40	21.60	54.70	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.39	0.70	-5.78	4	1583	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	297	6	0	1051	1	233.20	54	99.96	CHANGED	MSsLcElQ-pITtHEQQLVhARQKLKDAEKsVEVDPDDVNKSTLQSRRuAVSuLEsKLuELKRQLADhlusQKhsuKPVDPTGlEPDDHLKE+SuLpYGNVLDVNuIDlEEPSGQTADWhuIGsYIluFslPIlLKALYMLSTRGRQTVKENKGTRIRFKDDSSaE-VNGIRKPKHLYVShPTAQSTMKA-EITPGRFRTIsCGLFPAQIKARNIISPVMGVIGFuaFVKDWs-+I-sFLspcCPFL.....Pcstusutt.hhuT.RAYhhsRQstlspocl.DIssLhptApAuusTLhsDIpoPHSsWVFACAPDRCPPTsLYlAGlsELGAFFuILQDMRNTIMASKoVGTAEEKLKKKSAFYQSYLRRTQSMGIQLDQRIIlhYMlpWGKEsVNHFHLGDDMDPELRQLAQuLIDsKVKEISNQEPLKL	..............................................................................................................................................Ih.Ylhshs.sIlLKuLYhLoTRGRQT.K-NKGhRIRhKDDo....lNGIR+PKHLalShPsAQSoMKA-ElTPGRFRThlCGLaPsQIpsRNhhSPVMuVlGF.hhsKDWspRIccahtt.C.Fh..........sts..s.h..t....p.p.h..hN+sYhhpRQtsLst.cst-hptlhpaAtsusso..-pIcSPpu.WlFusAPDRCPPTs..........................................................................................................................................	0	0	0	0
+2860	PF03866	HAP		Hydrophobic abundant protein (HAP)        	Finn RD	anon	DOMO:DM07503;	Family	Expression of HAP is thought to be developmentally regulated and possibly involved in spherule cell wall formation [1].   	22.30	22.30	24.60	24.00	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.16	0.71	-4.45	2	5	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	3	0	0	5	0	146.80	39	58.77	CHANGED	MMKYlFlALChhAlV.LAoEs-.tcusp+..tLsVtG...LlsClVAllApIVuGLLRVIIGLVlTLSGVLpIVlGsVlhLVsslAuLALDlVtuoVsGIhsshLshshlhphlEEsL+s..uQ.LLsGLVpAlhALPLulLVALssLT-ulApuuCshGhStsGhh	...........................MMKYlFlALChhAlV.LAoEs-.tcusp+..tLsVtG...LlcCIVAllAsIVS.GLLRVVlGLVI.TLS.GVLQIVlGlVlpLVDllAuLALDlVsuTVTGIL.NcLLcFDhlhthlEEsL+s..uQ.LLsGLVpAlhALPLulLVALssLT-ulApuuCshGhStsGhh....................	0	0	0	0
+2861	PF01543	HCV_capsid		Hepatitis C virus capsid protein	Bateman A	anon	Swiss-Prot	Family	\N	21.60	21.60	21.70	21.70	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.72	0.71	-4.12	5	9598	2009-01-15 18:05:59	2003-04-07 12:59:11	12	23	146	9	0	6731	0	106.30	87	18.88	CHANGED	STNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARsPEGRoWLSPGTLGPShuhRAlsGpDG.C.....GhAGh..sPtsuRs.Ws.ssPhhR	...............................................................STsPKPQRK.T.K..RN..TN..RRPQDVKFPG..GG..QI..V..G..G...V.YLLPR....RGPR...LG.V..RATR..K.......T...SER.........S..QPR..G..R..R.....QPI.....PKA....RRPEGRoWAQPGYPWP......LYGNEG.h......GWAGWLLSPRGSRPSWGPoDPRRR................	0	0	0	0
+2862	PF01542	HCV_core		Hepatitis C virus core protein	Bateman A	anon	Swiss-Prot	Family	The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases [1]. The N terminus of the core protein is involved in transcriptional repression [2].	21.60	21.60	21.80	21.80	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.38	0.72	-3.59	6	7406	2009-01-15 18:05:59	2003-04-07 12:59:11	13	24	134	0	0	5245	0	59.90	89	8.38	CHANGED	SRNLG+VIDTLTCGFADLMGYIPLVGuPVGG.VARALAHGVRlLEDGINYATGNLPGCSFSIFlLALLSCLTsPAS	...SRNLGKVIDTLTCGFADLMGYIPLVGAPLGG.sARALAHGVRsLEDGVNYATGNL.P.GCSFSIFLLALLSCLTlPAS..............	0	0	0	0
+2863	PF01539	HCV_env		Hepatitis C virus envelope glycoprotein E1	Bateman A	anon	Swiss-Prot	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.44	0.71	-4.83	4	42235	2009-01-15 18:05:59	2003-04-07 12:59:11	12	27	140	1	0	24488	0	72.70	67	29.80	CHANGED	EVRNlSuhYaVTNDCoNsSIsaphsDAlLHsPGCVPC.+-uNsSRCWlsVTPsVAs+psuh.TpsLRpHlDhlVhuATLCSALYVGDLCGuVhLluQhFhhSPp+H.hsQDCNCSIYPGHITGHRMAWDMMMNWSPTsshllA.hhRlPpsllDhIuGAHWGVlhGLAYFSM.GsWAKVlllLLLhAGVD	.....................................................................................................................................................................................................................PssuhVluplLRlPQs..lhD.hl.AGAHW...G..VLAGlAYaSMVGNWAKVLlVhLLFAGVD.............................................................	0	0	0	0
+2864	PF01560	HCV_NS1		Hepatitis C virus non-structural protein E2/NS1	Bateman A	anon	Swiss-Prot	Family	The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein [2].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.19	0.70	-5.99	10	44241	2009-01-15 18:05:59	2003-04-07 12:59:11	12	24	122	3	0	25163	0	104.70	61	44.06	CHANGED	+VTGGssA+TTpulsShFosGu+QcIQLINTNGSWHINRTALNCNDSLpTGFLAuLFYsH+FNSSGCPERhASCRsIDcFcQGWGPIoYss..ssspDpRPYCWHYPPRPCGIVPApoVCGPVYCFTPSPVVVGTTDRpGAPTYoWGENETDVFLLNNTRPPpGNWFGCTWMNSTGFTKTCGAPPCsIGGsGNsT..LlCPTDCFRKHP-ATYoKCGSGPWLTPRChVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLsAACNWTRGERCDLEDRDRSELSPLLLSTTEWQlLPCSFTsLPALSTGLIHLHQNIVDVQYLYGlGSAlsSasIKWEYVlLLFLLLADA	.........................................sTGGusA+sstG.l....s.u....L....F....o....s....GspQsIQLINTNGSWHINRT..ALNCNsSLpT.Ga..lAuL.hYh.p...+...F.NuSGCPER.hASC+slspFsQGW.GPIsasp.....st.s.......-pRP..................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2865	PF01538	HCV_NS2		Hepatitis C virus non-structural protein NS2	Bateman A	anon	Swiss-Prot	Family	The viral genome is translated into a single polyprotein of about 3000 amino acids. Generation of the mature non-structural proteins relies on the activity of viral proteases.  Cleavage at the NS2/NS3 junction is accomplished by a metal-dependent autoprotease encoded within NS2 and the N-terminus of NS3 [1,2].	25.00	25.00	25.10	25.00	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.19	0.71	-4.87	29	2278	2009-09-12 04:23:25	2003-04-07 12:59:11	13	38	114	14	0	2355	0	183.60	72	9.16	CHANGED	DsppuuslGssVlshlslhTLoPsYKthLs+hlWWhQYhlsRsEAhlplWlPPLpsRGGRDu.lIlLsslha...PplsF-lTKhLLAlLGPL....YlLpsuLl+VPYFVRApsLLRsChLlRplAGGKYsQhsLLclGthTGTYlYDHLuPloDWAusGLRDLAVAVEPVlFSPMEpKlITWGADTAACGDIlpGLPVSAR	........................................DpEhAASCGGsVLVGLhhLTLSPaYKtaluhhlWWLQYFlTRsEApLpVWVPPLNVRGGRDA.lILLhCslH...PsLlFDITKLLLAlhGPL....alLQ...AuLh+VPYFVRsQGLlR.hChLsRKhAGGHYVQMAllKLGALTGTYVYsHL.TP.L+DWAHsGLRDLAVAVEPVVFSpMETKlITWGADTAACGDIIsGLPVSAR.....	0	0	0	0
+2866	PF02907	Peptidase_S29	HCV_NS3; 	Hepatitis C virus NS3 protease	Griffiths-Jones SR, Knutson S	anon	Structural domain	Domain	Hepatitis C virus NS3 protein is a serine protease which has a trypsin-like fold.  The non-structural (NS) protein NS3 is one of the NS proteins involved in replication of the HCV genome. NS2-3 proteinase, a zinc-dependent enzyme, performs a single proteolytic cut to release the N-terminus of NS3.  The action of NS3 proteinase (NS3P), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins.  The C-terminal two-thirds of the NS3 protein contain a helicase. The functional relationship between the proteinase and helicase domains is unknown. NS3 has a structural zinc-binding site and requires cofactor NS4A.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.80	0.71	-4.68	9	8309	2012-10-02 13:45:52	2003-04-07 12:59:11	10	46	119	110	1	6342	8	144.80	87	19.64	CHANGED	pGpl.VLuTuTpoahGTClNGVhaTsaHGAuu+TLAGPpGPlsphasssspDlssaPsPsGApSLpPCoCGusclYLlTRcusll.uR++GD.pssLhuPpPlSshKGSSGuPlLCspGHsVGhFpAAlsotGsspulcFl.PhEslsss	......................................EGEVQlVSTATQoFLATClNGVCWTVYHGAGo+TlAuPKGPlhQMYTNVDQDLVGWPAPs.GARSLT.PC.TCG.S..S...D..LYL..V.......T....R...H..A.....DV..IPVR.RRG....D...S.RG.....SL.....L...S..P.....RPlSYL.....KGSSGGPLLCPuGHAVGIFRA..AVCTR..GV..AKAVDFI.PVEshETT...................	0	0	1	1
+2867	PF01006	HCV_NS4a		Hepatitis C virus non-structural protein NS4a	Finn RD, Bateman A	anon	Pfam-B_315 (release 3.0)	Family	NS4a forms an integral part of the NS3 serine protease, as  it is required in a number of cases as a cofactor of cleavage [1,3]. It has also been reported that NS4a interacts with NS4b and NS3 to form a multi-subunit replicase complex [3].	21.00	21.00	21.10	22.60	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.64	0.72	-4.43	15	2766	2009-01-15 18:05:59	2003-04-07 12:59:11	15	42	118	67	1	2514	0	54.10	82	3.25	CHANGED	SsWVLVGGlLAAlAAYChosGSlVIlG+lslsGpP..................sllPD+EshappaDEMEEC	.......STWVLVGGVLAALAAYCLoTGsVVIVGRIlLSGKP..................AlIPDREVLYppFDEMEEC...............................	0	1	1	1
+2868	PF01001	HCV_NS4b		Hepatitis C virus non-structural protein NS4b	Finn RD, Bateman A	anon	Pfam-B_315 (release 3.0)	Family	No precise function has been assigned to NS4b.  However, it is known that NS4b interacts with NS4a and NS3 to form a large replicase complex to direct the viral RNA replication [1].	20.30	20.30	20.40	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.12	0.71	-4.91	11	2035	2009-01-15 18:05:59	2003-04-07 12:59:11	14	36	116	2	0	2032	1	181.50	82	8.46	CHANGED	hp.pshshlssAstpApshpshlpo.....h.s+hpphWsphhhNhhShIthhsuh.shstNPslushhuFhhulooshssphpLhhslLhGhsuotLusPssuhAhssAhhAGuulso.hLu.lllslLuGatuuVsuA.lsFclhuGchs.s-DhhsLlsslhSPGAuVsGVshuslLhphhs..tGuspWhNRLls	..........................FKQKALGLLQTAo+QAEshsPsVpo.....sWp+LEsFWAKHMWNFISGIQYLAGLSTLPGNPA.IASLMAFTAulTSPLTTppTLLFNILGGWVAAQLAsPu.AAoAFVGAGlAGAAlGSlGLGKVLVDILAGYGAGVAGALVAFKIMSGEhPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLIA.......	1	0	0	0
+2869	PF01506	HCV_NS5a		Hepatitis C virus non-structural 5a protein membrane anchor	Paterson M, Bateman A	anon	Bateman A	Family	The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2].  The N-terminal region of the NS5a protein has been used in the construction of the alignment for this family.  The C-terminal region has not been included because it is too heterogeneous.	20.50	20.50	20.60	20.70	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.48	0.72	-6.96	0.72	-4.20	19	5540	2009-01-15 18:05:59	2003-04-07 12:59:11	14	38	115	5	0	5082	0	22.40	82	2.09	CHANGED	usWLhDlWDWVsplLschpshL+	...GSWLRDlWDWICpVLoDFKTWLp..	0	0	0	0
+2870	PF04618	HD-ZIP_N		HD-ZIP protein N terminus	Kerrison ND	anon	DOMO:DM04570;	Domain	This family consists of the N termini of plant homeobox-leucine zipper proteins. Its function is unknown.	21.70	21.70	22.10	22.90	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.77	0.71	-3.54	11	75	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	25	0	39	87	0	93.00	39	35.13	CHANGED	Mt.ccD......cLGL..SLSLuhstppts............................tpss.phshtPs.................sop.pptsuppthhsspss-tpoFLRGIDVNRhPuss............-h.EEE.sG...VSSPNSTlSS.lSG.KRSppctp	..................................................................................................................huh..uhtLs...........................................t......................................t......t..t.....tspphp.....hsh.lRGIDVNRhPsss.............ch.-E-..sG...VS.SPNSTlSS.hSG..KRuppp.s.................................	0	5	21	27
+2871	PF02329	HDC		Histidine carboxylase PI chain	Mian N, Bateman A	anon	Pfam-B_19599 (release 5.2)	Domain	Histidine carboxylase catalyses the formation of histamine from histidine. Cleavage of the proenzyme PI chain yields two subunits,  alpha and beta, which arrange as a hexamer (alpha beta)6. 	25.00	25.00	28.30	28.00	15.80	15.10	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.96	0.70	-5.78	4	71	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	62	34	9	58	3	262.60	46	94.92	CHANGED	csKlpthchD.....ppAISP.+caCpGYhpPGsh.GNGYVoslKlSsGsVDhoD..hLDu...............IVSYDRsEpNDAYlGQINMhTASSFsGlpGtlWGaDlAhp-sltpcK.hPLYpppQ.-Gss.....lPVYsh+PLL-As.cLFGptc..cRRFsshPGuaVlCANKusTA.cPp..tshK.G...hVWSsIuLulhcDRs+susLFlEDAGla..css.....sc--lhtaLEsph+tsTpSls.CGpDpHlha-chaIGatYshhcPGQlGsALoCAPYVoLApsAlPus..hpPuc....LspholSpW.-chshcsL..p..pK	......................................................s...............+hAluPacpascGYh.PGsh.GpGYVosLKVssGsscKT...DD.lLDu...............IVSYDRAEtpsAYlGQINMhTASSFsGhtGplhGaDlhtpspl..cc.pPLap.pQaDGoc.....L.lYDu+PL.-uhlEhFGTpc..pRRa.shPGAalhCANKulTA.RPpp..spshp.GpuYGVWShIAlShupDtscsushFlEDAGlW.tcss.....sE--lhtaLcs+R+uhshSlspCGcDp.....p.....lhacpoaIGFAashMcPGpIGsAlTsuPYlshshsulPut..hhPs.....hpphohspWL-cMsapsL.......t...............	0	4	7	8
+2872	PF02924	HDPD		Bacteriophage lambda head decoration protein D	Griffiths-Jones SR	anon	Structural domain	Domain	\N	29.00	29.00	29.00	29.00	28.40	28.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.43	0.71	-4.31	74	818	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	475	18	82	442	27	110.10	37	93.51	CHANGED	shspshp.hu-hLhhEussph.SR-ssslsuG....sslssGoVLG.....tlsA...o................................................................................................Gc...asshsss.us...DGu.p.sAsulLhtslsAoss.cspsss....lsttu.lspssLsassuhss.sp+ssAhspLssh.uI	..........................................................................p....s.p.thp.hh.usss.s..tTusGshuts.....sssPAhTPLM......LDsu......o......................................................................................................GK...LVsW...........DGp...t....pAVGILs.l.sl-s.T......psslTa...YKSGo..Fsh-slhWP-uss-.pKKtsAFAGoA.....th.................................	0	28	48	67
+2873	PF01517	HDV_ag		Hepatitis delta virus delta antigen	Bateman A	anon	Pfam-B_808 (release 4.0)	Family	The hepatitis delta virus (HDV) encodes a single protein, the hepatitis delta antigen (HDAg).  The central region of this protein has been shown to bind RNA [1].  Several interactions are also mediated by a coiled-coil region at the N terminus of the protein [2].	25.00	25.00	26.00	25.90	21.90	21.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.26	0.71	-4.62	4	1108	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	61	5	0	1072	0	117.60	80	89.58	CHANGED	MSQo-sR+sR+G.REEhLEpWlsuRK+tEELE+DLRKspKpIKKLEE-NPWLGNlhGIIRK.cKDGEGAPPAKRsRpDQMEVDSGPtKRP+tuGFTDpERcDHRRRKALENKKKQLSuGGKpLS+EEEEELRRLT-EDEcRERRlAGPRVGsVNPh-GGPRGAPGGGFVPSMpGVPESPFoRTGEGLDIRGoQtFP	...........................................................................................................................KQLuuGGKsLS+EEEEEL+RLTEEDERRERRVAGPpVGGVNPLEGGsRGAPGGGFVPSMQGVPESPFoRTGEGLDlRGsQGFP.......................	0	0	0	0
+2874	PF02985	HEAT		HEAT repeat	Griffiths-Jones SR	anon	Reference [2]	Repeat	The HEAT repeat family is related to armadillo/beta-catenin-like  repeats (see Pfam:PF00514).	23.50	17.60	23.50	17.60	23.40	17.50	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.53	0.74	-7.59	0.74	-3.39	590	1878	2012-10-11 20:00:59	2003-04-07 12:59:11	17	196	359	47	1138	5988	309	30.50	27	3.66	CHANGED	llshlh..phlp...Ds..s.pVRtsuspslsplsphh	...........hhshlh....phhp....Ds..sspVRpuAspsLsphsp..h.....	0	419	626	897
+2875	PF03130	HEAT_PBS		PBS lyase HEAT-like repeat	Mifsud W, Bateman A	anon	Pfam-B_172 (release 6.5)	Repeat	This family contains a short bi-helical repeat that is related to Pfam:PF02985. Cyanobacteria and red algae harvest light energy using macromolecular complexes known as phycobilisomes (PBS), peripherally attached to the photosynthetic membrane. The major components of PBS are the phycobiliproteins. These heterodimeric proteins are covalently attached to phycobilins: open-chain tetrapyrrole chromophores, which function as the photosynthetic light-harvesting pigments. Phycobiliproteins differ in sequence and in the nature and number of attached phycobilins to each of their subunits. This family includes the lyase enzymes that specifically attach particular phycobilins to apophycobiliprotein subunits. The most comprehensively studied of these is the CpcE/F lyase Swiss:P31967 Swiss:P31968, which attaches phycocyanobilin (PCB) to the alpha subunit of apophycocyanin [1]. Similarly, MpeU/V attaches phycoerythrobilin to phycoerythrin II, while CpeY/Z is thought to be involved in phycoerythrobilin (PEB) attachment to phycoerythrin (PE) I (PEs I and II differ in sequence and in the number of attached molecules of PEB: PE I has five, PE II has six) [2]. All the reactions of the above lyases involve an apoprotein cysteine SH addition to a terminal delta 3,3'-double bond.  Such a reaction is not possible in the case of phycoviolobilin (PVB), the phycobilin of alpha-phycoerythrocyanin (alpha-PEC). It is thought that in this case, PCB, not PVB, is first added to apo-alpha-PEC, and is then isomerised to PVB. The addition reaction has been shown to occur in the presence of either of the components of alpha-PEC-PVB lyase PecE or PecF (or both). The isomerisation reaction occurs only when both PecE and PecF components are present, i.e. the PecE/F phycobiliprotein lyase is also a phycobilin isomerase [3]. Another member of this family is the NblB protein Swiss:Q9Z3G5, whose similarity to the phycobiliprotein lyases was previously noted [4].  This constitutively expressed protein is not known to have any lyase activity. It is thought to be involved in the coordination of PBS degradation with environmental nutrient limitation. It has been suggested that the similarity of NblB to the phycobiliprotein lyases is due to the ability to bind tetrapyrrole phycobilins via the common repeated motif [4].	20.90	13.00	20.90	13.00	20.80	12.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.44	0.74	-7.55	0.74	-2.93	221	340	2012-10-11 20:00:59	2003-04-07 12:59:11	11	54	166	1	174	4509	751	27.50	31	10.24	CHANGED	lRttAstuLuplss..............pulshLhpsLps	....hRhtAAhuLGplts..........................pAl.ssLlpsLp...........................	0	65	142	163
+2876	PF00632	HECT		HECT-domain (ubiquitin-transferase)	Bateman A	anon	Prosite	Domain	The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.	20.40	20.40	20.40	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.28	133	4368	2012-10-03 14:42:41	2003-04-07 12:59:11	20	240	341	23	2797	4212	88	293.50	28	21.16	CHANGED	phl.....spchh.s.sp.........shF...............................................................................h.tsspt....hhh.s....................................................................a...phlGtlluhulhs.......sh.h.....lslpFs.hha+............................................hlh.....................ttt......ls.hpDlt.p.....................lDsphhps.lptlh..t.p.t......................................h...slsFs.h...t......................................................................................................................................................................................................................................................................pL..h..s..G...psl.VTp..pNtpcYlphh....hca.hlpptlppphps........hpcGFt..pll.s......tphlp.hFsspELphllsG.....ps.p.......lshpsLcptsp..ap.tsas.....tss......................ttlphFa.cl..............................lpp.hsp-pppphLpFlTGss+lPh..sGhp.th..........php.....Ipphss..............................................................................................ss..t....LPoApTCa.shLcLPp..........Ysop-hhcc+LhhAlpps.p..s.Fshs	...................................................................................................................................................................................................................................................................................h..l.pphh...s..s.......h...shF...................................................................................t.p.pt........hh....s..............................................................................pphph................................................F...ca.l..G.p.l.lG.h..........Alh.c.........sp..h................l-.h...FshshaK.................................................................................................................tlL...................................................stt.......hs..h.pDlp..p.......................................................................l.D...s..phh...pu.Lhh...lh......pts..t...................................................................................tl......sLs..Fs..ls.pt.....................s.h.......................................................................................................................................................................................................................................................p..........................h-.L....h.ss..G..................psl....V...T...p.............cN.+.p-.Yl.c.hh.............spa..ph....p....p....t....l..p.p...Q.hpA......................Fh.....c..G.Ft...pl..l.s........................p..h.....l..p.....hF.....s.........pE..L...c..h...l.l.s.G..................s..c.............................lDl..p..c....hcpp........opY..........c...tsas.............ts..p..............................hl....p...h.F.W....cs........................................................l....pp....h....s....p....-.......c....+.....t....ch...L..p..F.lT....GosR.....lPh........tG......Ft..tL..................................phs.......I..pphs.t.........................................................................................................................................................................................ts...p.....LPp.u.p...T...............C..a..N.....h.....LcLP..............Y...p.o.....h......c.....hLcc+LhhAlp.ps.t.u.Ft.............................................................................	0	1023	1454	2163
+2877	PF03451	HELP		HELP motif	Bateman A, Suprenant KA	anon	[1]	Family	The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family.  The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain [1].  In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation [2].  The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.	21.90	21.90	22.20	22.10	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.51	0.72	-4.46	7	705	2009-01-15 18:05:59	2003-04-07 12:59:11	9	111	107	0	408	642	23	69.00	42	8.56	CHANGED	cpG.l+halRG+slshhhPsc.h.shc.sscp-hPsp+LcL-WVYGYRG+DsRsNlalLPTGEllYFhAuVsVLash-	............................................................Ppt........p..tt.c.p.chP.....s..p.cL+L-.a.......V.....YG...YRG.+DC.R.s.NL..a.hL.s.............s......G.......E........l.VYalAuVsVlYNh..........................	0	124	162	260
+2878	PF03996	Hema_esterase		Hemagglutinin esterase	Finn RD, Marshall M	anon	Pfam-B_505 (release 5.5)	Domain	\N	25.00	25.00	50.60	50.60	20.70	19.60	hmmbuild  -o /dev/null --hand HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.92	0.70	-5.16	6	382	2012-10-02 11:02:24	2003-04-07 12:59:11	10	4	208	19	0	295	0	323.80	45	74.88	CHANGED	hspplLlssShuhshGF...............scPhsssSHLN.sDWhhFGDSRSDC...sNsu.Pp.shhshpss.phSuK.Suphh.SlFts.HhoDah..YpGpGpphVFYEGVNFSPatuacChspG.sphWhs.KspFYsplYchhup.RslSlVNl.hshss.shssulCKssspshspsshlhpppshssphhpsctshshsshs.............tsCphhhsshplaNspthusph.shhspastslsshs.hssssTtspssuhDhsCcYLtLpPGsYpuhSsthhLshPoKuhChcphc.hsPVQsVpShWspsRpSDshsu.ACp.sPYChFhNpossYsG..stDsHHGDtchRplLSGLhYsusCISQQGshshsssSoph.hhP..YG+CPpAAclts	....................................................................................................................................s.PpsssShLN.usWhhFGDSRoDp...sNss..p.u.hshpsA.phpuh.uuphh.ShFts.thsDah..YpGpGpphlFYEGVN..aoPatAhcChpps....Whp.KhtF.pplYc.hu..+shohVNs..hh.s.t.stuhstsss.sh.psshlhpptshs...htsctshh..s.................s..hh.shphastchhsshh.h..sp.hhshsshs.hs.s.Tts.sss.shpCchl.L.sGpY.shSs.hhLhhPp+uhChshpc.hsPVpsVpShWspsRpSD.hss.AC..sPhChhhppppsYlG...hD.pHGDtthpplLSGL.Ypu.ChSQpGhhp.sss.o...LhP..aGRCPhAAc.ps.............................................................	0	0	0	0
+2879	PF02710	Hema_HEFG		Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein	Finn RD, Bashton M, Bateman A	anon	Pfam-B_505 (release 5.5)	Family	\N	25.00	25.00	36.90	36.90	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.17	0.71	-3.92	12	364	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	203	19	0	284	0	131.10	47	29.16	CHANGED	pFYppLYphhuh.Rslphlsl...p.shshost.psshCp....ssphh.sNPpalshpsshss........spFsLsu......CscaLVPhChh...suthhssst.....hhps.thaYs.Do.hhYGasssss......stthDhsCcYL.lcPGsYpAhossh	..F.pplYchhu..+slohVNs...shshpsost.ssu.Cp......s.hLpNPAhhspEsp.s-.hht.E..A.FsLss......Cc.alVs.ChF...stcshsppt.....hhs..QhhYspsstVlhGLsspho......sss.shpCchl.LpPGpYpshSs..t..	0	0	0	0
+2880	PF00509	Hemagglutinin		Haemagglutinin	Finn RD	anon	Pfam-B_26 (release 1.0)	Family	Hemagglutinin from influenza virus causes membrane fusion of the viral membrane with the host membrane. Fusion occurs after the host cell internalises the virus by endocytosis.  The drop of pH causes release of a hydrophobic fusion peptide and a large conformational change leading to membrane fusion.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	550	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.87	0.70	-6.37	15	50634	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	45867	505	5	30865	0	432.00	51	96.33	CHANGED	IClGYHusNSocpVcTlhEpsVsVTpupELlEos+ssclCshp.....stpPlcLtcColtGhlLGNPpCDhhLs.psWSYIlERssu.suhCYPGsl.shEELRplluSstpap+lchhscs.sWssshsss....GsosACppsuss.uFaRslsWLsKp.....psssYPshssoYsNTcsp-hLhlWGIHHPsossEQssLYpsussh.loVuTpohspsasPpIGsRPtVs..G...QuGRhcaYWoll+PG-olsFpoNGNLIAPcauaplsspu.u.sIhposlslssCsocCQTstGuINospPFQN.lsphsIGcCPKYVKssSL+LATGhRNVPplp....pRGLFGAIAGFIEGGWpGhIDGWYGF+HpNupGoGhAADpcSTQcAIDpITsKlNslI-KMNppF-sls+EFsclEcRIpsLsc+l-DshhDlWoYNAELLVLLENp+TLDhHDSNVpNLaE+VRRQLR-NAc-tGNGCFElaHKCDspCMESIRNGTYDHscYcEEu+lNRpcIsGVKLcSss.sYcILsIYSslASSLlLsshlhGhlhWsCpNGshRCpICI	.................lClGaHAsssss...hVcTlh-cplpVTpuspLlpsppsG+lCs.......shtsLchtsColhshlLGsPpC-sh.s.ppWshlVE+usu..pusCYPhDhsDYppLRplluSs...tphEhhscs.sW.stssps....GsS.uAC.+susp.SFappLhWLs+......psssYPsLshoasNscpp-hLhlWGlHHPs.o..ss-QpsLYtpusuh.loVuTp+hppphhPpIusRP+VR...s.....QsGRIshYWTllcPGDtlhhpusGNLIAPRhsFtlpps..........tSuIhpSDsPlspCso.pC.TPpG...uIsss...hPFQN.lp.lThGtCP+YVKpspL+LAT.GhRNlP.php...........oR.G.......lFGAIAGFIEsGWpGhlsGW.aGapppstpG.u.AAD..................................................................................................................................................................................................................................................	0	2	4	4
+2881	PF01126	Heme_oxygenase	Heme_oxygnease;	Heme oxygenase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.20	20.20	20.30	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.32	0.71	-4.76	18	1215	2012-10-02 21:56:19	2003-04-07 12:59:11	15	7	902	120	452	1089	282	182.30	20	75.77	CHANGED	ssLuppLRcuT+csHshAENssFsKsFLpG.lscpsY+pllusLYalYpAlEcEhccp+spshhuslhFP.ELpRpsuLccDLsaaa.G.ssWcptlpsosAsptYVpRl+clusp...pPcLLlAHuYTRYLGDLSGGQlLK+................................................IAppuhsLsss.pGhuFYcFssls...spptFKppYRptLssl.ls-pppppllcEAspAFthNhplFp-	..............................................................................h..hsttl+ttTpt.Hpth.-........p..hhtt...h.....................hs.h.ptahphltt.ah.......hap....s.......lE.t....th................t........................................................................ht.h.h....s...pL...h...R.pt.t.LtpDlt.hh............h..s..............p.h...........t.........t........................h..........t.......s...............................s.......h..t......t...h......s..t..c..l..c....p...............l......spp...........pst.....hhluahYsh.h.u.sLu.GGp.ll.++................................................................................hhtpt..hs..l...s.t.....p..............t..........u..hp..........ahp...a..s...s...................sttth.hptac...pt...l...s...p..l..s...h...s.t.p.p.p...p.phlppAppuFth.hthht..................................................................................................................	0	109	241	359
+2882	PF00372	Hemocyanin_M	hemocyanin; 	Hemocyanin, copper containing domain	Finn RD, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes arthropod hemocyanins and insect larval storage proteins.	20.80	20.80	21.20	21.10	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.72	0.70	-5.11	14	743	2012-10-01 19:27:11	2003-04-07 12:59:11	14	15	199	48	195	807	0	247.20	31	41.35	CHANGED	s.aElaPphFssu-sIp+Aaph............chtp.....................................................ph.-cs............hlhcsphosslh..spEp+luYFpEDIGlNsaaaaaHhsYPFaasschaGthK-R+GElaaYhaQQlhARYchERLSNGhscl..FpahcslcpGYhP.hhplssGh.au.RPsshplcshcshc.lp.h-caccpIh-uIppGalps.cGppIsLccscul-hLGsllpu....ss-sssh.Y.atoLcshu+hhluthscPps+aphsPulh-papTSLRDPlFYpha+hIsNlFpc	.....................................................................................ElhP.hFhs.sphl.pu.......................................................................................................................................t....................hhl...h..s..ao...s...s...h.....p.Ep.+luYFpE..DlGlNsaa.......aaaHhs.Y.........P....h....h...h..p.....p....h...........s....h.p.K.D......R..+GELF.aY.hHpQllAR...YphERLo.N....sLsclp.h...s.a.h.c..s.l.p..G.YhP..hh.p.h.h.s...G.ht.as..sR......ssh...ph......p......c.....h.............p.......p......h.....p..................l......p....chppacpRlh-AIp.pGa....l....hs.t....sG.....p.p..lsL.p......p..................c........u....I-hLGs.hlcu...........s....Ss.s.pa..Y.....G.s.lashu+hhl.uh.p-.sp..tc...a..................suVhtch....p.TuhRDPh....F.Yphaphlssha........................................................................	0	61	85	176
+2883	PF03723	Hemocyanin_C	hemocyanin_C; 	Hemocyanin, ig-like domain	Finn RD, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes arthropod hemocyanins and insect larval storage proteins.	26.40	26.40	26.40	26.70	22.10	26.30	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.60	0.70	-5.24	163	687	2009-09-11 10:37:18	2003-04-07 12:59:11	9	13	179	48	209	753	0	235.80	31	36.26	CHANGED	ssYTc-......-LpFsGVplssVpV.p..........LhTaa-ph-h-losul.shs.........................schslhs+hp+LNHcPFsY..pIpVps......spssst..sVRIFluPKaDph..Gp.hshs-pRhhhlElD+FhhcLpsGpNsI...sRpSp-SslTlscphoaccLhpph.ts.sttt.h...........php.stCGaPp+.hLLPKGpt.pGhsapLFVhlosaptspl.tpt........s.sshshCGht.sppYsDp+PhGaPFDR.l.........spht.a.h....NMthpDVpIhac	...................................................sYoppcLtasG..VplpslpV.sp.............................LhTaacp.-hDlssulshs..............................phslhu+hp+LsHcPFsaplsVp.s......spstpt.......sVRlFluPKhDph..G.p.....h.s...h.p-pRhh.hlElDcFhhp.LpsG..p..N..sI...pRpSp-ssholspchoap.pLhpph.tsh.p.t...h...........ph.ph...stCG....aPp+.hL..LP+G.p..p.Gh...hpLalhlosaptsps..tp......................p.ssh.h.CGht..sphasDp+shGaPFDR.l..........ppht.h.h...sNhhhp-lhIha....................................	0	59	86	184
+2884	PF03722	Hemocyanin_N	hemocyanin_N; 	Hemocyanin, all-alpha domain	Finn RD, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes arthropod hemocyanins and insect larval storage proteins.	21.70	21.70	22.60	21.70	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.50	0.71	-3.97	111	668	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	164	48	193	736	0	113.70	27	17.52	CHANGED	shhpKQpplhpLhp+lpps...h.t.chhplupsap.......tp.t.a...pcsch...spp.hhp.h+pshhLs+schFSlappcphcEAhtLaclLatA..KDa-sFh+sAsasRpplNEGhFlYAlslAllHRsDscGl	.............................................................t..lh.lh.ph.t............phhthspph.........t....t.h....tp.ph......hpp..hh..hphs.hLs+sphFSla.tcHtcpAh.tLhclhhtu....pDa-sFhpsAsa..uRp+lNpshFlYAlolAllHRsDscsl.................	0	49	75	166
+2885	PF00045	Hemopexin	hemopexin; 	Hemopexin	Ponting C, Bateman A, Sonnhammer ELL	anon	SMART	Repeat	Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).	21.30	21.30	21.50	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.30	0.72	-4.22	76	5321	2009-01-15 18:05:59	2003-04-07 12:59:11	14	87	208	96	2483	4600	17	44.70	26	26.74	CHANGED	lDAshphp.......schaFF+GspaWchssp......php.shPp.lssh..ulss	.................hDAshphpt..........uchaFF..K..G.....s..p..aW.+...assp..........php...s...u...aP...+.lsph...uls.........................	0	348	533	1140
+2886	PF05171	HemS		Haemin-degrading HemS.ChuX domain	Finn RD, Bateman A	anon	COG3720	Domain	The Yersinia enterocolitica O:8 periplasmic binding-protein- dependent transport system consisted of four proteins: the periplasmic haemin-binding protein HemT, the haemin permease protein HemU, the ATP-binding hydrophilic protein HemV and the haemin-degrading protein HemS (this family). The structure for HemS has been solved and consists of a tandem repeat of this domain.	20.40	20.40	20.50	20.40	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.37	0.71	-4.33	108	1015	2012-10-01 19:49:10	2003-04-07 12:59:11	7	7	499	8	260	1007	60	130.00	33	72.42	CHANGED	sloctphltstsu......p...hsppls..ss.........hpplLpthtphG.tlMshstNcuslp.+sGsh..pslp.t.....G........hh.lLss...s..hsL+LhhsphspuasVc+sT......pc.G..hhpSlphFDspGsslhplaspcp....s-hs..uWctLlp..pL	.......................................loctphhtshss.........c......h.Ah+lp...ss..........l.tplLps.hppsG...clMshstNc.usVp.psGsh..p.p..l....p...t.......s.....t.......hh....l.lss...p....hsL..+..Lh.sphAps.aslccsT.................sc..G...hhpSlphFDtpGs..t..ltpl..aupcp..........s-hssWcplluph.......................	0	53	127	187
+2887	PF00906	Hepatitis_core		Hepatitis core antigen	Bateman A	anon	Pfam-B_8 (release 3.0)	Domain	The core antigen of hepatitis viruses possesses a carboxyl terminus rich in arginine. On this basis it was predicted that the core antigen would bind DNA [1]. There is some experimental evidence to support this [2].	22.60	17.00	22.70	22.70	22.50	16.80	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.32	0.71	-4.63	12	7177	2009-01-15 18:05:59	2003-04-07 12:59:11	15	10	91	27	0	5167	0	125.70	89	88.87	CHANGED	DIDPYKEFGAoVELLSFLPsDFFPSlRDLl.DTAsAL..Yp-ALpSsEHC..SsHHTAL....RQAlhCWtElhsLuoWVGsNLpDPsuR-LVVsY.........................................VNsshGLKhRQLLWFHlSCLhFGR-TVlEYLVSFGVWIRTPssYRP.NAPILSTLPETsVVRp..Ru.....RoPRRRTPSPR.........RRRSQSPRRR.................RSQS.pSpC	.............DIDPYKEFGAoVELLSF.LPSDFFPSlRDLL.DTASAL..YREALESPEHC..SPHHTAL....RQAl.lCWG-LMsLAoWVGsNLpD.huR-hVVsY.........................................VNsphGLKhRQlLWFHlSCLTFG+psVlEYLVShtsh.....................................................................................................................	0	0	0	0
+2888	PF01771	Herpes_alk_exo		Herpesvirus alkaline exonuclease	Bashton M, Bateman A	anon	Pfam-B_822 (release 4.2)	Family	This family includes various alkaline exonucleases from members of the herpesviridae. Alkaline exonuclease  appears to have an important role in the replication of herpes simplex virus [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.50	0.70	-6.03	14	226	2012-10-11 20:44:43	2003-04-07 12:59:11	12	6	154	6	18	307	11	373.60	23	77.26	CHANGED	s.hsplsshshsp.FLcss.htphhu......pptsthstlRasYhahlhh......phsshhusst............................ssshhtcthttshsst...............................plsplhtts....................pphsscttpplhhhlEttTRGQu-NsLWclLRcGllouSKhhausp.t.phs.+hFps.shpsspasuu......sltFGh+sEpsl+sLlsphhs.......sc.................................tsspshGhLhsPpsGlhGsSLDhhss..s.tpuptshl.hpsssplaEIKCRaKYLFsKs-..DPhhptYtpLhppPsttsLtcFlhSIs+PuVEahssG+lPots-aLlTpDtsWc.ts.p++tshsst+ph...htcplthNptspSpVhlhs......DPstspupIsh...................................................cuthplslFsNPRHsYFaQlLlQphVl.ppYlphpssP....pLso.tshlsouhFRc.......R.tssshsCplssc...tl..sscIPllLIlTPVhlstp.shpchlpputshWp.psspcpasph.sWsssus	...............................................................................................................................................................................................................................................................................................................................................................................................................................hs.t.h.t...pth..hh....hlEptTRuQucs.....tLWplLRhshhTASphp.sst...t............s.....s..t..hhp.........h.p...s....t...hp.ss.............ulhFGhppEs..........hs.+.......s......l.ltphhht................................................tsshsCGhhhsspsGhhGAShDh.hhs........p.s..s...h..t..h.h.aElKCRhKYhhp.....p.h.t...tlhtt.s...hhthl.sh..Pslpah..tt.Pt.t-hLhs.p..h........h.............thh..Nt...S.lhlhs.................t...ttt.h.................................................................................h..shFhNs+H..ahQhhlQ.hlh.t.a.t...............s.hhp....t........R.................................t.tlPhhhllTPl.hs...hh..h.tts...ht.t.ht..............h..................................................................................	0	14	14	18
+2889	PF04793	Herpes_BBRF1		BRRF1-like protein	Waterfield DI, Finn RD	anon	Pfam-B_6247 (release 7.5)	Family	Family of herpesvirus proteins including Epstein-barr virus protein BBRF1.   	25.00	25.00	86.70	86.40	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.65	0.70	-5.64	10	28	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	21	0	0	22	0	273.10	29	93.11	CHANGED	aHYP-lssllpElcslsl.ssshsppppPssp.LERulaLsKlhQlLhQHRppEppIlPplpsNlhYaLspLpchsssctpphlpslLscl..sssDhtLsscLsphlsclLpl+YPsthsl.....sppssshspWCLpahlGlspph+phlsssLsstc.sShPSlpshspLu+pLFhspuhhpEsasDssFNh.hNQlVaWTsslchappClapchls-oIsshpsLLKpEl+uFhpWhcppp......phpshthlcahcahlcplTsssocsclsElhphLpcsK...+sLhs	aHYPslspllpphsslsl..ssh.s.tppPhhs.lcRuLaLs+lhQlLhQH+ppEphIlPplpspltYhLptLpchsssch.pphI...tplLshl..sssshsLppcLhphlsclLthcYPpthsl........ssshtpWCLpahl.Glotph+phlpshlsotp.sshPShpshspls+pLFhspsh..EshtcpsFN..hN.slFWTsslphappCIapphlhcpIssh.sLLKtEl+pFhsWhc.pc......phtshshlpahcalhcplTsssoph.hsElhshL+HsK...+sL......	0	0	0	0
+2891	PF05109	Herpes_BLLF1		Herpes virus major outer envelope glycoprotein (BLLF1)	Moxon SJ	anon	Pfam-B_6348 (release 7.7)	Family	This family consists of the BLLF1 viral late glycoprotein, also termed  gp350/220. It is the most abundantly expressed glycoprotein in the viral  envelope of the Herpesviruses and is the major antigen responsible for  stimulating the production of neutralising antibodies in vivo [1].	25.00	25.00	409.60	409.50	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	830	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.69	0.70	-13.61	0.70	-6.58	3	270	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	6	1	0	74	0	437.20	62	100.00	CHANGED	MEAALLLCQYTlQSVlpLsuDDPGFFNVElLpFPFYP+CcVCTADVNlTIlFcVGscs++L-LsFGs.LTPpTKuIYQPlHAoGGpENATsLFlLELLGAGpMALTMRSpphPINlSc.-EppVSlEAlhVYFpDsFDlhWCH+VpMp-PVYLIPcplPPll..WNcCNSTNITAVVRAQGMDlTVPISLPTpPp-SsFSl+hEMsGNGIDhpCchEss.ISPVLPGsNsFsITCSGDKPHFASGGILTPsSPssTPsPhsGYsYSLpLsPRPVPRFLGNsSpLYlaYohsGPcu-GGDaCIposIsFSDcLPTsQDMPssTQsloYTGsNATYpLsMAsSEs.NTAPNVTVTAFWAWuNsTpoDFKCKWsLsTssQpPsGCER.........huGtFsSNRTFElTVusssssuKTLIIoRsATNsTsssaKVlFoKAPDoTpos.hl.ThsastPppTTulPoosplP.....PsoouPThpstDPTSsTPTGhTS.................SphP-sTSPTSsoTosTPNATSPTsssT..TPNATSPTosKTSs.......TPNsTSPTslVoGsTosATSPPoGsTSs........PNATSPpVuEpSP.sNTs.........TPsVTpsPSVlTssshsuphGsoSSPTSuhouhPpo.....ssTPRsNSTSsTP.LTSsHPTGGcNITEsTPuuPST....sHVSTuSPuPsPGTTSQsuGPGNSSTSscPGts+VTcGhPspNATSPSAPSuQcTsVPTsTssGGKANsTT..KcToGSshtuSTpPsTstGusuTTs...YNATT..PPosSSpLRPRWT.TuPPsTTsQATVPVPPTp+P-aSNLSMLVLQWASLuVLTLLLLLVluDCAFRRsSSplHTYTa..PPYDDu.ETtV	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2892	PF04633	Herpes_BMRF2		Herpesvirus BMRF2 protein	Mifsud W	anon	Pfam-B_5353 (release 7.5)	Family	\N	25.00	25.00	190.20	190.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.20	0.70	-5.48	10	24	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	21	0	0	22	0	348.00	30	98.13	CHANGED	pschsLshsuFssGsLAAoPFlWCFIFtoLaohshassWpotlah.WuhsssplshlhaCllphsp..hsRtlchlsslslhsshhsFhhpshshuhhshlPsLFllNhlhLslWlhlsh-sVYLCPsIhp+YaELGFLsAhslY.YlllppplaloslFhhPFhlFlshGlhuLpsl+++shYcpGlpRR+uIF.spsuKYhshShppshchssh-LlllssLlsuhssuhluLslaTclhhGlspYlaLFhsGshsCGGlhl.sSphhshVashluslshhLlalhsstlshhsppshlhslhlhsahpAlGCplphIRpKL++slNuPpllLslCsLsNlllslshhllsK	......schsLshtuFshGhLAAoPFlWCFIFtoLaohslaoshpshlah.WuhsssplhhlhaCllshpp..hsRtlchhhhhslhsshhsFhhpshshuhhhshPsLFllNhhhLhlWshlsh-lVYlCPsIhpRYaELGFLsAhhla.YhlltptlalosVFhhPFhlFlshGhhuLtsh+c+slapsGlpRR+uIF.htps+Yhshohppshchssh-lhslhhLlhshssuhlultlhoclhhGlspYhhLFhsGhhsssGlhl.pSphhshVhhhluslhhhllalhtsthsshhppshlhslhlh.hhpAluC.lphlRpKLp+slNuPphhLtlChlsNhllslshhslsK..	0	0	0	0
+2893	PF04682	Herpes_BTRF1		Herpesvirus BTRF1 protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4518 (release 7.5)	Family	Herpesvirus protein.	25.00	25.00	125.00	124.80	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.59	0.70	-5.05	12	30	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	25	0	0	27	0	245.40	37	66.63	CHANGED	hshhsshK+VpINEutNpthha-spp.l.phPh...................ssh.s+sIlKp......stsspst.....hhAplFaAhut.hP.plGpsPspsasTlhIMsRSpNSLphlP.shplsslQ+LFLKHVLLtchGLENshpsF.tlasp.lsslospQh.phFcpllppsKp+lEDhVFsLNSIspt.FptsVpssssss.thphAhEKYFLMFPPtD+.psAlpFuusllclICpGsshsclltFLp+YlsIpccsstsNhlKlYALLol	.........................hhpshK+VplsEusNphhhh..pp.l.ph.....................pht.s+sIlK+...s.ss..p.tsh.t.t.hAplFaslup.hP.plGpuPsssasolhIMsRSpNSLphlP.shclsslQHLFLKHVLLpphGLENhlpsFpslYss.hsslospph.ctFEpllppsKpplEDhVFCLNoIssppFptsVpssssss.slhpAhEKYFlMFPPps+.psAlpFuAsll-lICpGsslsclltaLsKYhsIp+csstssLlKlYALLol.	0	0	0	0
+2894	PF04929	Herpes_DNAp_acc		Herpes DNA replication accessory factor 	Finn RD	anon	Pfam-B_5837 (release 7.6)	Family	Replicative DNA polymerases are capable of polymerising tens of thousands of nucleotides without dissociating from their DNA templates. The high processivity of these polymerases is dependent upon accessory proteins that bind to the catalytic subunit of the polymerase or to the substrate.  The Epstein-Barr virus (EBV) BMRF1 protein is an essential component of the viral DNA polymerase and is absolutely required for lytic virus replication [2]. BMRF1 is also a transactivator [2].  This family is predicted to have a UL42 like structure [1].	25.00	25.00	254.70	254.30	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.33	0.70	-5.49	11	24	2009-09-11 06:58:28	2003-04-07 12:59:11	7	1	21	10	0	25	0	391.10	34	98.89	CHANGED	shuhplcsssLsptsKlY-HlKuclK.sGlIQ......lsG.sssPsLullSslGssGlLsFclp.sAluphpspp.......phscssolSFRN.puhGsTFlaoRELFGssVcsAsltFY+R....tssupP..pFV+splpYsDslTpTpHTSsl.pstl.Phpcplpsspshu+VlLosKTsshLQKWLRQpKo+t..psV+VslNETLuVll.loVG-soKTlDaKsss..t.sstshsssKstDsGsVpsDssspVul-uLhsALulCKIPGlhlPsh+FauusILEVsGs.lKpup.ssssLSVhLLsssspscssst...sh..........sulsspsppsssssssuPP..............................tsspspopp.sssotsPssshs+s.t...ohpR..KRpsc.........pcc+sKKhKhsFNPLI	..phshplcsssLuphuKlY-HlKup.lK.sGlIQ......lsGss.ssPsLulluslGsuGlLshclp.sAluphhspp.......ptspssuhSFRN.puhGsTFlaoRELFGssVcsssltFY+R....psuupP..pFV+splpYsDsso.pTpHTSsl.pshh.Php-+lcssthhu+VlLssKTushLQKWLRQp+op...psV+VolNEsLuVhs.hTlG-soKTlDaKPhs....ss.tttshsssKstDsGsVpsDssspVul-SLhAALulCKIPGshlPsl+FauusILEVsGs.lpsus.sslcLSVlLhpssspspssus...s.........................sulpppspp..ssssssssPP................................s.tts.psposs.u.sopsPssshp+s..ss..p.p+..KRpucp......pppcc+sKKsKhsFNPLI.	0	0	0	0
+2895	PF01673	Herpes_env		Herpesvirus putative major envelope glycoprotein	Bashton M, Bateman A	anon	Pfam-B_1084 (release 4.1)	Family	This family consists of probable major envelope glycoproteins from members of the herpesviridae including herpes simplex  virus, human cytomegalovirus and varicella-zoster virus. Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication. 	25.00	25.00	54.20	54.10	21.50	17.90	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-13.16	0.70	-5.94	32	143	2009-09-11 13:51:45	2003-04-07 12:59:11	13	2	85	0	0	123	0	494.60	31	93.89	CHANGED	lh...sEllhtuHhhpl.........shhssshtsssss................................................................................ph..h..s.........hsssLslDpsCplCpllshhh+c.s.s.pWhtDYAhLChKCltAPhsssuohlsAhEFlalhcpHF.stptss...hFspphlolhDlphHFFlppCF+...............................tpssshlphuNhoaltpuhhRuhLhsptssshshhphh...........................................s.t.shtthccpscsssCs..............................tp......................................th.tt................thsassLlhhlhuGossh.tts.....................h..lhts+tptlcphhpppt..................................ht.ssps-hshGPlLloslhthpp+spTso.ClLCpllss+sp.hhsL+pL+pcllsaspNNlpLhDpIp.lLsshts......................................hs.hpDtsthhtll+tsGspulaKHhFCDPhCAhNttpTsPpVL..Fspsss...ccLphhKAplAstNpatspl...CptLasLshhFKuaQlhphp...tTslusFl+-hstlL++HslsLls.taTlshYV	.........................................hsELLhtuH.hpl....sh.p..t.s.sss..ss...s........................................................................t....-hs.h.ts.........hsssLulDptChlCphlplhh+p....shs.pWltDYuhLChKChtAPhsAhushlsAhEFlalhcpHF.phptss...hFtppsLTlhDlphHFFlppCFc.....................................ppss..stVphsNhohht.ussRAhlhs.sssshsttpth............................................s.tthltsac-pup.hc................................................................................................................sassLlhhhhuGTssh.pss.....................hpths.ts+tttlcthhpspp...............................t.hh..ssps-hshGPlhhoslhthps+spTss.CLLCpLlhspha.hlsLRcL+pcllsYspNNsplhDpIt.Vlssh.st.....................................ts.htssshhhtll+tsGspuIaKHhFCDPhCAhs.hpssPtVLFscsss.....cclphhKAtlAssNhat.uRl...CttlhhLhahFKsaQlhh.p....TtlusFlR-hstlLcpHslsLls.paTlspYV................................................	0	0	0	0
+2896	PF02480	Herpes_gE		Alphaherpesvirus glycoprotein E	Mian N, Bateman A	anon	Pfam-B_849 (release 5.4)	Family	Glycoprotein E (gE) of Alphaherpesvirus forms a complex with  glycoprotein I (gI) (Pfam:PF01688), functioning as an immunoglobulin G (IgG) Fc binding protein. gE is involved in virus spread but is not essential for propagation [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.67	0.70	-6.22	19	334	2012-10-03 02:52:13	2003-04-07 12:59:11	11	15	88	4	23	302	1	298.90	33	76.66	CHANGED	Phsssshhscs.................WshL.ssss......t.t.lClp.s.ChtDllls...spC...shchsls.......hAphhh..tshppsssshhh..ssslhsphsssp.....ssLpltsAstssuGlYsLhsp...sssstsptss..hhVtVtstttt....................................hsstPh.....h.hsP..pp+Gsphplpsa+uhlassGDoFplslplpsthaD..ssFshplcWhahcs.sspCs.h+IYEsClaHPptPpCLpPsc.ssCuFuSshhupplus+hYtsCstt....hsscC..sssphctsstlpht...sssssLhhpsAssssoGLYV..........hVlhhNGHlcAWsYsllSTssp.ahNslp-hshPth................ssssssssssstss.stshst.hhhhlsulhusAsllhlsslsshsshtppppRchhp........thsshussYsuLPss-.......h.p.sp.Dspss--phs.tppt..................................sspppGSGap	............................................................................................................................................................................................................................................................................................................................................................ss..th+tsph+h.s.cu.LFuPG-TFsh.splhu.htDp.tsashslsWhhhcs.sspCh.hhlYEsClYHPphPECLpPsD.ssCuhoS..hsphlAhRsYusCS.h......stC....h-AahE.l.................pssssptuGLYl..........hVh...............t.t......tsh.p..hP.h..................s...tst.st.........st.h.hhhhhh.s.hhhhh.hhhh.hhhhhhphtpct..t................................t.hY.h..tl....s..c......................................................................................................................................	0	15	17	21
+2898	PF01688	Herpes_gI		Alphaherpesvirus glycoprotein I	Bashton M, Bateman A	anon	Pfam-B_1222 (release 4.1)	Domain	This family consists of glycoprotein I form various members of the  alphaherpesvirinae these include herpesvirus, varicella-zoster virus and pseudorabies virus. Glycoprotein I (gI) is important during natural  infection, mutants lacking gI produce smaller lesions at the site of infection and show reduced neuronal spread [1]. gI forms a heterodimeric complex with gE; this complex displays Fc receptor activity (binds to  the Fc region of immunoglobulin) [1]. Glycoproteins are also important  in the production of virus-neutralising antibodies and cell mediated  immunity [2]. The alphaherpesvirinae have a dsDNA gnome and have no RNA stage during viral replication.	20.30	20.30	20.30	21.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.86	0.71	-5.11	13	161	2012-10-03 02:52:13	2003-04-07 12:59:11	12	1	49	0	0	151	0	161.00	44	44.88	CHANGED	splLhsllLhulhls...upulVaRGspVSLhssossss.ulhP...s-sslslhGcLlFlscQhPsss.YsGTlELl+as.s.spCapllpshpYsuCPRlpssAFpuC+ppcshp.s.stsplpsslcstsLLpIspPpssDuGlYhLRVplss.sssuDlFslslhlh	........p.LtuLllluLals.....usuLVhRGsoVSLsosS.lsA.AlsP.............hl--DLhlhGcLhFlGsQlP+oshYsGsVELhHYshu.p+C.RVVaVlohouC............PRpsAsAFshCRsscstH.oPAYssLphslsppsLLRlppsshc.AGlYVLRVhVss.AssAulFsLuhsl.h....	0	0	0	0
+2899	PF01528	Herpes_glycop		Herpesvirus glycoprotein M	Bateman A	anon	Pfam-B_929 (release 4.0)	Family	The herpesvirus glycoprotein M (gM) is an integral membrane protein predicted to contain 8 transmembrane segments [2]. Glycoprotein M is not essential for viral replication [1].	25.00	25.00	31.70	31.50	23.20	22.50	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.21	0.70	-5.76	30	163	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	92	0	0	141	0	329.60	26	92.25	CHANGED	MpsS+sDphth+hWhhplssaslhalssslssluAsFPsl.GFPCaasslVDYushNho......stNttptlTP.......sLFL-ssphhsYlhhohllhhssslYYlluultlhpt++.tssshsshps...lshlGossslahulLphWTlQlFlhsLSaKhlhLAAFsYslHFhh.shastshlophss.hthtpthpsl.c.sshLcpllhph+slhsNlhhshlulphllhuLohthulGNSFalhlucslhuulslFhlLsllahllsEhhLs+Yl+h.hGaalGsllusshLhhPll+Y-shF.......suplpsslslslullsllslshhllRllRhhhtp+pcpscYhslspsst......phc..hp.................................hp.s.csshhpp-ss	..........spsDphsh+hWshplshhslshlshsshhlhAsh.th.GaPCaassllsYtthNho.......shshhthhsP........LaL-s.phhsahhhshllhhhhhhYhllusltlhhp+c.pshphpthtp...h.hhus.solhhuhlphWhhQlhlhhLua+h..LuuhsYhlHFhhhshassthsoph.s...h.pthhtl.c.pstLcthl..h+slhsNlh.hhluhphhhhulshthhhuNsFhhtssphlhsshshFhllslhhhllhEhlls+Yl+h.hGhalGshhuhshlhhsshcYtshh.......ssshppsltsslullsllslhhhllRhlRhahh++p.+pscahshspsst.....ppht.h.t............................................ppps..s.........................	1	0	0	0
+2900	PF01537	Herpes_glycop_D		Herpesvirus glycoprotein D/GG/GX domain	Bashton M, Bateman A	anon	Pfam-B_603 (release 4.0)	Domain	This domain is found in several Herpes viruses glycoproteins. This is a family includes glycoprotein-D (gD or gIV) which is common to herpes simplex virus types 1 and 2, as well as equine herpes, bovine herpes and Marek's disease virus. Glycoprotein-D has been found on the viral envelope and the plasma membrane of infected cells. and gD immunisation can produce an immune response to bovine herpes virus (BHV-1). This response is stronger than that of the other major glycoproteins gB (gI) and gC (gIII) in BHV-1.  Glycoprotein G (gG)is one of the seven external glycoproteins of HSV1 and HSV2. This family also contains the glycoprotein GX, (gX), initially identified in Pseudorabies virus.	19.90	19.90	21.60	26.50	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.91	0.71	-4.17	22	286	2012-10-03 02:52:13	2003-04-07 12:59:11	12	2	62	13	0	265	0	111.50	34	26.10	CHANGED	lthst.s.cuCplslLts.sshs.thppt.........asAoluWahhhss.......CthPlhhR-YhsCssst..u..sCsthShshhps..shssauhlsts....LlhsPuhhsuGpYhh.lhls.sphhsuclhl	......h........tsCthllLtsssps..hh.sus.............YsApVsWa+lspu.......CtpPIhlhpYssCpsscs.u..sCs.thThshhss..s.spauhlsss....Lhhsss..suGpahh.ltls.s.hhhsphhl..	0	0	0	0
+2901	PF02489	Herpes_glycop_H		Herpesvirus glycoprotein H	Mian N, Bateman A	anon	Pfam-B_1142 (release 5.4)	Family	Herpesvirus glycoprotein H (gH) is a virion associated envelope glycoprotein [2]. Complex formation between gH and gL has been demonstrated in both virions and infected cells [1].	20.00	20.00	20.30	24.80	17.60	19.50	hmmbuild  -o /dev/null HMM SEED	657	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.97	0.70	-6.52	30	314	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	106	20	0	262	0	524.70	23	85.33	CHANGED	hssphhcpLaspsslsEsLtshhp+hpphapss....sshphsst.s.ssssssspsspsls.spshphssh...h.s.h..lps.......pplhp.ha..pp.shhhps....pslhashcstshthslth....sspsplsstlTpsFhhlolp........sp.pslshlFGpspclsslKu.hshp.shthspsspasLlllsshps.hspt.h.hhp.shtchhhphsphshtthh.pplpshhhth..hpstCp.ts.hs.pphhphhFphslshFhhscsh..ttsphlslspllcphspLphlpchhppCassh...................htshphs.........s..lpphusstltshshpph...tphshtppphhlpthhhs..spph..lssptlptltpllpslYppashsh......L..ssssRchLahhhtllp..................spohpssphthhalltTSMCostElup........hsphhupscshslhchFSPChhSLRhDhop-+Ltp.hspss..................s..phspsssshhshLcshcts.shphhstl.pCls.....scshhl..lPlsshT.YVISsch.lspGhsYsVosshlssshhlosl...pssCphs.ssttssppIPslhNlo...pppC.saCs.SsllpYDEssGlpshhYIsspplpppLhsstsshh.ssN.+sH.....YLlLhsNGTVlElpuhhppc..shshlhlllhhluhhlulalLY+lh	.......................................................................h..............h...h.................................................................t....h..........thht.hh....t..hhh.pt.............hshhashth.sh.h.hhhh......tpthhhhhhhs.sFhhlslp........sp...h.hhhs.....h.....hps.h..t....s.h..ts.paplhlls.h.p...ph..hhh..shht.h.p....t..h.h....t.hphhhh.....h....tt.st.........hhphhhthshshFhhspt....tst.hslsphlph.ttlh.ltp.hh.hp.shtth....................h.lh..................p....h.ph.th..hht.s.ht..........h..h.thhhhhhh......tp.......hst.hhp.......htphh.thapphhh.h......L.........ss..RptLhhh.thlh.......................t.tpthpthhlh.ouhCs..chst............hhph.tp.p...l.chaoPCh.uhRhDhs.phhh....h.tts.......................hstts.thhshlp...t...h....p.p...hhthh..sth...pC...........sp.hhh..lsls.p.hs.Yllopph.h.pGhsY.lsss.ltpslhlohl...pssCp..t.p..hp.shplshh..Nhs.....tC..hCt.ushhpYspstsl.shhhlps.p....h....h....ss......hsp...hh.s.sscsH........hLhLh.NGTVlclhsh.hct..shphhhlshhhlushlslhhlath........	0	0	0	0
+2902	PF02689	Herpes_Helicase		Helicase	Bashton M, Bateman A	anon	Pfam-B_607 (release 5.5)	Family	This family consists of Helicases from the Herpes viruses. Helicases are responsible for the unwinding of DNA and are essential for replication and completion of the viral life cycle.	19.00	19.00	19.00	19.00	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	819	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.46	0.70	-6.80	15	968	2012-10-05 12:31:08	2003-04-07 12:59:11	9	38	270	0	294	964	161	251.50	33	46.34	CHANGED	schs...........................sphhLNhTStsclc.IVc+I+pLSp...tsspsPp.hsWFcshh-sEsshsh.h.........................................LPFusYLITGTAGAGKSTSIQsLspsLDClITGATsVAAQNLSspLstsh..salsTIFpsFGF+SpHlshp..........Rh.hstsss.soIcclQ+pDLshYWsVlsDIsc+hhpt.................cphtthsshohsuhushscsuhPsLscSNlIVIDEAGlLu+HILTAVVFhaWFaNAhhcTPhYcsGtlPCIVCVGSPTQTDAlpSsFsHppQ+pcV+pu-NlLohLIsNcsLpcYsclscNWAlFINNKRCsDsEFGcLLKsLEYGLPlo-EhhcYVDRFVVPcuhIpNPsphsGWTRLFlSHpEVKuYhupLHspLcls...........tssphslFThPlhshVpscsF--Y...KctlspPuLol-cWLppNhsRLoNYSQFtDQDhusspsEh..........s-pu.....................................hllThclpYV+NSploVTuKsKKslhGFoGTacpFtplLcsDuFl-spuc-psEYAYsFLSsLLauGMYsFYsahhssu.st....phhpcLsplslP.ht.....pshsusss.....................................s-h.D-s...............shLspps...DhFYppYphsPssoohshsElhuhYpslKslFlsRaslhpchFGspFspuPFsTas.sNlsh+sstpFsSs.c.hsGLLuaAsss-oYTLpGYTassVhhhsp-tpp......hhphhhppchPplVl+DppGFlSlLcsNlo+hsEol-s.pplchsossDYGISSKLAMTIsKSQGLSL-KVAlCFuss.pNL+huplYVAhSRsssucaLhMNhNPLRpphE...csshlSpHIlpAL+sssThLVY	......................................................................................................................................hht............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lt.p....h..AMTIsKSQG.SLc+.Vulshsps...shphuphYVAhS..RsTS.p........c.hL.+...h.............................................................................................................................................................	0	106	204	254
+2903	PF03324	Herpes_HEPA		Herpesvirus DNA helicase/primase complex associated protein	Mifsud W, Fenech M	anon	Pfam-B_3676 (release 6.5) & Pfam-B_4951 (release 14.0)	Family	This family includes  HSV UL8, EHV-1 54, VZV 52 AND HCMV 102.	21.10	21.10	36.20	34.40	20.30	17.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.96	0.72	-3.95	32	154	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	84	0	0	151	0	93.30	30	12.85	CHANGED	hslpDlFpsp-hsltlts........t.lpl+llsPh.sFchlhssspsh.shuLhshaptlaspla.u....shpulhPlasYlsPphh.pGss..a..sl.....hFPGFPhl	............s.huDlFplp-sslh.ps.............t.hslRllhPt.hachhlosspsh..hsLhuhapphassla.u......shsulsPlasYLGP-h..pGssh.a.......sl......hFPGaPsl..	0	0	0	0
+2904	PF03585	Herpes_ICP4_C		Herpesvirus ICP4-like protein C-terminal region	Bateman A	anon	Pfam-B_1422 (release 7.0)	Family	The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection.  ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer.  ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region [1].	25.00	25.00	34.00	29.80	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.49	0.70	-5.76	13	161	2009-09-11 08:11:53	2003-04-07 12:59:11	9	3	37	0	0	135	0	321.00	49	27.44	CHANGED	GGFRRhPsGssHTP.........sPucushpAYCsPcslucLsDaPLFPpsWRsALsFDPpALApIAARssussst.....................spthGshsussPLRRRsAWM+.QIsDPEDV+VVVLYsPLPGEcLsssssss...s..ttPpWsspR.GGLShLLAALuNR.LCsP-opAWAGNWoGsPDlSuLsAQGVLLLSTcDLAFAGAVEYLshchuuA+RRLIVlDTVssE-WPpDGPA.lSphHlYlRsslpPsuQCsVRWP...sspcLuRAVLsSuclFGPusFARl.EAAFARLYPsssPLRLCRuuNVRYsVcTRhGscTsVPlsPR-YRptVLPuhDGppchstQstuhshGsPDFl-GpAaSHRAAsRWGLGAPLRPVYLupGR+uutu..uPct..lPtslRsFCtpALLEPDs-ApPlVLpsspuss.............hsssPultWssuhGptsT.l	.......uuaRp.P.G..hs..........hPsttshtAYC.sthhhtLh-..hhP..Wp.sL.asPtAhAplAthtss...................................sst.LRthsAWMp.Q..sP-DVpllllYsPLstEcl.s....s..........asst+.GGLShlLAALusR.lChPsotAWAGsWTu...PDlusLst...pGVLlLSTpDLuaAGAVEaLt.hh.usucR+LlVlDsVs.pcW.PtDGPA.lSp...h...HlYlRsshpPsuQss..VRWP...sscsLtRuVhsSucsFGPusFARl.EsAaApLYPst.PLpLCRGGNVtYpVpTRhs..o.VPhsPhtYhthVh.s...ptt............tsDF.tttuhSHRAst+WGLsA.LRPlal..u+.shh...tPt...h...hp.hCttslL.PDstA.PlVl.....st..s......................stl.W..t.......................................	0	0	0	0
+2905	PF03584	Herpes_ICP4_N		Herpesvirus ICP4-like protein N-terminal region	Bateman A	anon	Pfam-B_1422 (release 7.0)	Family	The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection.  ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer.  ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerisation [1].	25.00	25.00	102.60	102.30	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.13	0.71	-4.76	14	132	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	38	0	0	132	0	174.20	51	12.23	CHANGED	sssGEsWPsusPPPtGRVhaGusG-pRpGLWDsP-VcpAttRapAusuPsPVaVPEhGDssKQYpALVchlas..sp-s..huWLQssKLousDptLschC......p+hhsus+upGo.......hlTGoVssslPHlGcAMAsscsLWALPHsAAuVAMSRRYD+sQKsFlLpSLRRAYAsMAaPtsus	.hssGEPWPGusPPPsGRVhaGssG-oRpGLW-sPplcpAttRacAustPssValPEhGDsucQYctLlchlYs.Pst-s..huWLQNPKLossDtsLsphC.......+l..hssuRupGo.......hlTGSVApslPHlGcAMAsGcshWALPHAAAAVAMSRRYDRsQKsFlLpSLRRAaAshsaPcsus......	0	0	0	0
+2906	PF03361	Herpes_IE2_3		Herpes virus intermediate/early protein 2/3	Mifsud W, Fenech M	anon	Pfam-B_2178 (release 6.6)	Family	These viral sequences are similar to UL117 protein of human  and chimpanzee cytomegalovirus, and to intermediate/early  proteins 2 and 3 of certain herpes viruses. UL117 is thought  to be a glycoprotein that is expressed at early and late times after infection [1]. This region is close to the C-terminus of the protein and may be a transmembrane region [1].	25.00	25.00	48.90	44.20	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.74	0.71	-4.91	14	91	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	27	0	0	96	0	159.10	35	28.34	CHANGED	Phpshs.+plhpcshclC+phpspspsIhhhaTRoppVtpslcsh+pcLhphsNlolSsPFphpHT.PhhHs.cssppsschpppGsppsW-hpcsp.s....HshssRpSDh+ohhIpAATPhDFlsAs+lClphupcaPKplslRlsol.psuht...LPIYssssc.	.....Phphssh+plh-Esh+hC+shpspspsIhhlaTRspplcstlcsl+scLhphsNlslSssFhhpHT.shsHsPcsuppTtchpppusptsWshcc.p.s.....+phssRpSDh+sMhlpAATPhDLlsAlpLClslspKaP+plslRlhsh.psuhhh..LPIYpphsc.h.................	0	0	0	0
+2908	PF03363	Herpes_LP		Herpesvirus leader protein	Mifsud W	anon	Pfam-B_1664 (release 6.6)	Family	\N	25.00	25.00	29.70	29.60	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.91	0.71	-11.96	0.71	-4.69	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	7	0	0	46	0	111.30	67	134.18	CHANGED	RGD.SEuPGPoRPGPPGlGPEGPhGQLLRR+RssSPTtGs.E.P+RVRRRVhlppE-tsVSGsPotPRGD.SEuPGPoRPGPPGlGPEGPhGQLLRR+RssSPTtGs.E.P+RVRRRVhlppE-tsVSGsPsuPptPh.Q................PsApShREWLuRsspRssspPVsTh.RRRVYIEEEEE.	.....hGD.SEssGPsRPGPPGlGPEGPhGQLLRR+RssSPTtGs.E.P+RVRRRVLVQQEEEVVSGSPS.PRGDpSEuPGPoRPGPPGlGPEGPhGQLLRR+RssSPTpGGQE...P+RVRRRVLlppE-.psVSGsPs...................................................	0	0	0	0
+2909	PF03122	Herpes_MCP		Herpes virus major capsid protein	Mifsud W	anon	Pfam-B_600 (release 6.5)	Family	This family represents the major capsid protein (MCP) of herpes viruses. The capsid shell consists of 150 MCP hexamers and 12 MCP pentamers. One pentamer is found at each of the 12 apices of the icosahedral shell, and the hexamers form the edges and 20 faces [1].	25.00	25.00	40.20	40.10	14.90	14.40	hmmbuild  -o /dev/null HMM SEED	1354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.16	0.69	-14.22	0.69	-7.25	32	190	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	98	2	0	182	0	1168.50	38	98.62	CHANGED	stls.ssuslLspI+.outctLFcsFchhhG-DspcYslpF-sLLGsYCNslpaV+FLETuLulAClss.cF.DLphMs-G+lQFclphPpIA+uss+sss+.sphhlsKtscK+slossFplustsLplLptshps.T.l-phhplpAlppls+slphslDAhERGhlDphLpVLL+KAPPhhlLpsL.pcshhspRshs+lsRuslluphKp+lhpshFFLs+sp......+phlhphLs-hlsus.ppSVhpstsTaos.ssGc.lsGVllTTssVhppLlshlsp.lsctssssPssYGpaVlsGpNLVTAlshG+sh+sF-phsp+llshtps....tsp.p.........psp.spsplsssllplG-+hVhLEuLc.RVYpsTpssaPLtppl-lTFaFPlGLahP...s+YoT.uuplps.....tssscp..PspsaFhNKDphlhplsapsALtTlCHPphhssssslpuLptt.h....ssstch..............t.phauhthpp..sthslhphhhpFac...s+h.sshsshshcsphos-pFh+PsN..hLthELHPhFDFaht.tssshs............shtAohRlhsGNIP.PLuPssF+-uRGtQlts..shppl..ssuTlphlpsThpDssYPhlhYllEAhIHGsEctFshhhpLlupCIpoYWpsstpLAFlNSFtMltaIssaLGsGtlsc-sauhYRclhuclpsLcpsltchsh.s-slss.pshtthssuLhDssLLPPhlac..hs.ll.csp......Rssplpsssp.hsss...sc.ttlshh.+hpshhsctsshhss.ssss..h.hh.t.........-hhlLpKIaYYsllPAhopG+sCuhGVcacplhhsL...pss......................hss-....hsss-cs.hs............pLhssslpslhpsucls.sssshl.tpLttshhpssppTpslclpsshDsupppussp.shpshpssLaNGhhhhuhscpspthh.psaFYPlPhpthausP.....tlssshssplpshlpchPt.........lPshLuuEYhpahRsPhspYu....spstss.solo.sLhuhahKLSPluhhtQh+ptlHPGFAhTVVRpDcFhsEplLaupRASpShFlGpPpVs++E.+ssulsFcloQshuslDhGLGYoushssAplpslsTDMGspsQsLFtshsstsatss-lssalRptluspp..s.....sshshhshGthpsssssGltHGQhAsCEhIlTPVouDlsYFppPsNPRGRuus..lhusDs.sppsAcphhYDHopsDsAasaRuTsNPWASQ+sSLGDlLYNupa+pp..sssshYSPCtpFFoss-lhppN+sLh+LlsEYss..ussssousT-lQahsssGTcphlEcPCthhQEAaPhLsAScpALLcph..................hsspssp..........uEsHhupYLIc-suPlpthlh	..........hhsssuslLopIchuutcplF-.FphhhuD-sphYslpF-sLLGsYCNplphV+FLchuLulAshss.+F.-LshhspG+l.Fclp.PhIApssshsssp.hp.hhsKhhc++slshsFplustslshLptph.s.T.lsthhplcAlpplhRslpsshDuhERGhhcphLplLLcKAPPh.hlL.sh.pc.h.st+hhs+ltRuslluphKpphhps.FhLs+st......+phl.thLschssus.p.Slhhsh.Tass.spGc.lsGVlVTTsslhppLlphlhp.lpcppsssPsoYGphVlsupNhVTAlshGpshtsh-phsp+llshppp....p.p.......t...tst.ppspltscllplG-+hVhLEuLc.RlYpsTps.hPL.tph-LTFhhPlGLa.P...cpYushsuclt......psssct..PpplaFhNKDphl.plshpsAltTlCHPshhsspssltshppt......ch..................t.p.hthhhtp...s.hshhphh.pFhp...tch.hspsp.hhcsphoscpFhpssN..pLhhELHPhFDFhht.tssph.............th.sT.RlhsGNlP.sLsPssF+-sRGhplt...thpth..t.uTlthlpsohpD.sYPtlhYll-uhIHGsccsFthhhpLlspCIpsYWpspphlAFlNsathlthIssaLGsGtlPppshshYRclluhlphltphltphsl.stplss.ps.tthsphlhD.tLlPPhlac......h.+st......csstl.sssps.ssht..hp.tths...Rhsshhhct..hhss..sst.................-.slhpKIaYYshlPAhops+sCshGlchcplhssl...psh......................lsP-...hhss--s.hs.......................................pLlsshlpshhpsucls.sssshh.hpL.hhhhphsEpTpsl.spus.Dsutppussp.thphhptsLasGhhhhu..ch......tpaFhPlPhpthauss.....shssshsstl+phhpphP..........lPshlutpYashhRpPhspas....tps.ss.pul...sLhuhaaKlSPluhhtQh+stlHPGFAhTVVRpDpF.s-plLaup+ASpuhhlGp.pVs+c-.pshussFplTQshusVDhGlGYoussssAtlppshTDMGstsQsLahshss.shhsspsstalRptssstp.......ssshsh.sFGshpstp.suh.HGQtAsCEhIhTPVosDlsYF+pPsNPRGRAus..hhusD..pptsspthhYDHspsD.uhsatuTsNPWASQchShGDlLYNsta+.p..tssshYSPChpFFsss-lhsps+sL.+llsEhss..uhsshsuso-hQahps.GopphlEpPCthhQEAaPhhsuos.ALLcsh....................hpspstt..........sEsHhupYlIt-suPlpthh.......................	0	0	0	0
+2910	PF04797	Herpes_ORF11		Herpesvirus dUTPase protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_6280 (release 7.5)	Family	This family of proteins are found in Herpesvirus proteins.  This family includes proteins called ORF10 and ORF11 amongst others. However, these proteins seem to be related to other dUTPases Pfam:PF00692 suggesting that these proteins are also dUTPases (Bateman A pers. obs.).	20.10	20.10	20.20	21.30	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.85	0.70	-6.01	23	85	2012-10-03 01:18:03	2003-04-07 12:59:11	8	1	32	0	1	104	1	307.40	23	75.33	CHANGED	hshshWsssltsshlpl.oNppslpltsspsp......LPhsssh.thLtcphsuFuhssolhshp.hspsshhlhus....pssplclhPtslhcsppslslplpsstps.lstGsLphhllslshlphstlhhhhhsspss..h..sssssptusthsspp.splplsGpsspossps.h.hhhsppshsFhc..........................................................................shs+lpstpstsshlpshphucshh+lslp..p.ptsttlphph.lpsshohh.ps.l..........sFpas..hthshptsp...l..lYsssshhlsPspshpVchsspYtsstssttss..hhlsspsssspahlps...s.WhPtsshplslpNsostPlplpsustluhAlFlh.....ptssssshschhhpptosslphsusl	...........................................................................................Wphpl..shhhh..Nh..h.h..tp.t......LPhs.s....lhpthssashs.sh.t......ht.shhhhhst.....ss.h.lhP.hl.p.pt.l.lhlps.....h..tthhhhlh.lp.h..pth.hhh..............sth.p.hp.hss...s.h.ltG..h.s.....p.tp...hh.s.h...hhp............................................................................sphp.......p.h..........hstthh+htht.....t.s..h.h...htsh........l..........sh..s.....s...st....hhslYscpslsIsPtcotpVhasstYhp.usstphsh..hllstpssps..c..hhlcP...slWhPussstlsVhNsSspslsIsssTplApAlFh...........tt...p.hht..sttl.hst.....................	0	1	1	1
+2911	PF02399	Herpes_ori_bp		Origin of replication binding protein	Mian N, Bateman A	anon	Pfam-B_1518 (release 5.4)	Family	This Pfam family represents the herpesvirus origin of replication binding protein, probably involved in DNA replication.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	824	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.50	0.70	-6.59	13	207	2012-10-05 12:31:08	2003-04-07 12:59:11	10	9	101	0	8	215	11	389.30	22	60.09	CHANGED	sYsSSsSLARhLYGsDLh-hlh+s..+P.uVolEpQscuPVsFPsPhssssRsVpVVRAPMGSGKTTALlcWLppsLt.usDtSVLVVSCRRSFTpTLtcRhscuGLs....................................GFsTYhsussYlMsst.a+RLlVQlESLHRVspsLLss..YDlLlLDEVMSTluQLYSPTMp.+LscVDulLhpLLRpCP+IlAMDATlNuQLVDhLutLRG-cslHVlls-YAosGFSpRpChlLcsLGs-sLtuslp.....tt.stpst......tsst...stt....psss.....FFucLptRLtuGcNlClFSSTloFSElsARFCtpF..TcuVLlLNSpcshs.DVssWupYRVVIYTTVVTVGLSFDssHFHSMFAYVKPhptGPDMVSVYQSLGRVRoLhcNElhlYhDuSGARu-PlFTPMLLNHVlussusWPspFsplTNhLCpsF+t+Cssua....ttucshhLFsRFKYKHhFERCTLssluDSlNILHsLLssNplpVph-Gsp...slss...csFssFLpsL+tDAhsup+cl+pLR................tsssshshssplh-s-...sVusFhcKY..LRssVss..p-lhpLlpsLus.PlsRtpFlNlslLc...AC.........htlPsAlcSpcVFp+lYs+YAoGslP.........llu..sGtlEhssLssshNssspW.-La+LCsphAcsLslsstpssss.s........lssssllpshsschsp.htphlLElh+CslT-uphhsccsVptstshLuGttstpht..shSptcH...AlulF+lhWcplFGs+lsKSspTFPGssRVKNL+KpEItuLLDuhslDRous+THRpLYsLLMpp+ppFpp.sRY+LRsPsWuchlp.p..........-h.....LEsuLuclsspsWPpspG	..........................................................................................................h....hh+ushusGKT..h.ht.hhtt...................ph...hhl.......shR.sh.tph.tph.................thh..h.p.........pt......ht.........tplhhplpSl.h+h......t.......................h..-..llllDEl.p.hhtp.h.h.o...hh...p...p.....ht..s.....t.hhh.hltts.pllhhDAshst.hhphh...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	5	7
+2912	PF03325	Herpes_PAP		Herpesvirus polymerase accessory protein	Mifsud W	anon	Pfam-B_3097 (release 6.5)	Family	The same proteins are also known as polymerase processivity factors.	25.00	25.00	331.80	74.80	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.82	0.70	-4.86	6	52	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	27	2	0	48	0	243.10	52	71.12	CHANGED	MsAsDasMEFSSsCVHGQ-lVRESGcSAlRVDLDaSVVuELLKWIuPpTRsKRssK+ssssssTsQIlVHuNPPoIKF.LsssSELEFTAosRVuFH-VKNMRlsVQhKNLaQALsNCAVTKLuCoLRllo-H-shLaluSKNuhFoVENFLTEEPF.RuDstF-Rthtppps.............slsNust.pss...........s-.h............s+Kt-R......ssRp.stt.........-H..ttG.upcsKYE.QHKITSYhVsKsuuuuG........-R..osaFNDsKEESDSEDSVoFEasPNoKKQKCu	.....MsAPDaNMEFSSsCVHsQDl.lREotsSAs+VDLDauVVu-Ll+WIuPphRsKRNsKKtsssouTVQIhlHusPPslKF.Ls...ssSELEFTAsNRVuFHtVKNhRlsVQhKNhaQsLhNCAVTKLsCTLRlhT-H-ThLaVuS+Nu.FslENFLoEEPF.RuDs.....F-+..htt.................s.sNusshpss..ssG.D.thhs-.h................s+KH-R......ssRKhsttGs..........tDH..ttG.upcpKY-.QHKITSahsoKGusuuG........-R...usYFNDsKEESDS-DSVoFEas..PNoKKQKCs....	0	0	0	0
+2913	PF04846	Herpes_pp38		Herpesvirus pp38 phosphoprotein	Mifsud W	anon	Pfam-B_4545 (release 7.6)	Family	This protein represents a conserved region found in most herpesvirus pp38 phosphoproteins.	21.40	21.40	21.50	21.60	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.88	0.72	-4.66	5	34	2009-09-11 14:05:08	2003-04-07 12:59:11	8	1	9	0	0	24	0	61.50	59	25.88	CHANGED	ENsshRSthllsLlhSAKoLVlGSCMuFhAGsLIG+usclcoospssssLhhAFCAGhlssGl	.....ENATMRShMllTLIsSAKSLlLGSCMSFFAGhLVGRouc.V+TPlWDTVsLLMAFCAGllVGGV.......	1	0	0	0
+2914	PF04637	Herpes_pp85		Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25)	Mifsud W	anon	Pfam-B_5418 (release 7.5)	Family	This family includes UL25 proteins from HCMV, as well as U14 proteins from HHV 6 and HHV7. These 85 kD phosphoproteins appear to act as structural antigens, but their precise function is otherwise unknown.	18.40	18.40	19.60	20.60	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.56	0.70	-6.20	13	77	2009-09-11 05:49:28	2003-04-07 12:59:11	7	1	26	0	1	71	0	464.20	29	71.87	CHANGED	lD-pLNFhPslloscch+alpcsLspu.ssstVuhlNuslPMPsYsLEuLlcshl+pphs+s+slhcslI+lslhlN+YhsupchLcchpsthcshhsssp.hcRLcpuLppLh.pstpssssPhslhhtLscpsloputappsLcpLpclhcshshc.sschcs.pYppLpsaNhLapsPhaTopEAl-lYucNLpcLTpppscs..hcLloshpp..stsh-clLNDlhFLLSltphlhpapcpLptLRsaIhhplssLs-shYhsYsQlP-hRpsahsLsctltshhspsp..s-t.....FpshltsLhphl+plpcAsValsPsYl+ttlhth..hh.p.pps....ts.Dps.-tpp.....................h-.-ssushs.shhhspNshsss-lFRs.Pcss.phhtc..hhcpphopplhhsspssploscphplpphsplhhcuuuppsplsPcphhchh.........t......pst.t..t..husVphpsh.................p..pstp.s....uspssshssspPhusstp.p......tst	................................................................ls-pLsFpsslluspchcalttsLppu.ssstVshlNpslPMPsasL-uLl-shl+pthh+s+slhc.lIphslllNaYhsupchL+chpsthcshhsssp.hcRltptLppl..pstpspsss.slhhhlucts.lTtGtappsLcplcplhcshshptusctps.hYppLpsaNlLFpsPhaToptAlpLYtcNLp..cloppppcs..lcLLoshch..p.s.-csLNDhhFLLolpphlhpapcsLchLRsalhpphpsLs-hlYhsYsQsP.p.hRpsahpLsctlththspsp...D......hpshhtslhpFl+plpptslalCPsYlphslhtl.................h.Dps..........................ht.-.ss..u.s.hhstp.hsssslF+s.Pctspp.htc..hhpp..sh.hhhshpptphsspph.lpphhphhhpusph.stlsPcph.chh..p.hs.s.....................l..hsh.................ps.....ss....tt..t......sshP.p.h......ps................................................................	2	0	0	1
+2915	PF03326	Herpes_TAF50		Herpesvirus transcription activation factor (transactivator)	Mifsud W	anon	Pfam-B_3658 (release 6.5)	Family	This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.	19.70	19.70	19.80	20.10	18.10	19.50	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.51	0.70	-5.55	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	25	0	1	68	0	284.80	34	89.77	CHANGED	LFRN.Ks+pRupsuss.ssCAphuppll+alhERllhsTD+hFlsAsCSGVslP.sLApslaclhp-sRsKChuuWRpLussRRslMslucpllssYN.sLcssGhlSsch+AFhKLsFPshsLpplhpPlhthspGthsspshhshpG..up++RsspsshaSthsstspaslP-sLltshs-....sGLlssstsDlSsLLpNPppILp....hs.lupFpssssps..slPpsho.lssssoussPtp...sFtssasuso.........pssptpsostshustuspS.....sossptsplssS.ssts.sppshtuplshsosstPu......phsh.t..pssthP...........Pst.hsttp.p.........hssstlppshtsussppP..................tspPsusupps.sssush.pshss.ssossshpsssphsPshsp.ptpsssshps..............hsusshsspssp...........hsPuttp...........tDsslhshlppshssph-huuPss....hhhsshsp-l.p.sssPshcsspsstpt.-phsslssP	........................................................................................................................................................................................................................................................................pShLsauss-lShlL.pcsush.c...hsctsuPt..supThpP..ulPpspSchcPSPousssustp.spspstspuT.........ssspscssssPpuPpusop.....sossQcsp.sCS..s.ssusspssh..haspQsusshsu......plstsssssshshP...............................Pspspshppsshs................................................................................................................................................................................................................................................................................................	0	0	0	1
+2916	PF04843	Herpes_teg_N		Herpesvirus tegument protein, N-terminal conserved region	Mifsud W	anon	Pfam-B_3992 (release 7.6)	Family	\N	25.00	25.00	25.10	26.60	22.80	21.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.11	0.71	-4.84	23	211	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	85	0	16	203	0	173.50	32	6.75	CHANGED	Ss.sQuc.s+aGstAGsQClSNClhaLpssYhsG....ssllspcsLDslLcpGuclDthhcpssh......hs.spastls-lPshlpos...............hGpsshhhSp.h.Ghlpsps.s.pt.hlt.lchlhpsphpphsp.YhlhhssshutAlllp.ssphalFDPHspspt...ssAAVlsspsss-llsYl	....psQhs.schGPsu.GspClpsSlsFLphsahtG...hss.sLos-slDusLpEGuphspthpptsp.........sshsths-LPshlph................aGcssaa.stPhtG.hhp.Tpsss.pt........Fhttsatt+t.s.Y..sll..Tlssh....uhulhpp....scthalFDPHupsph.......stAhhspsphs-lh.al..........................	0	8	8	16
+2917	PF04523	Herpes_U30		Herpes virus tegument protein U30	Kerrison ND	anon	DOMO:DM04370;	Family	This family is named after the human herpesvirus protein, but has been characterised in cytomegalovirus as UL47. Cytomegalovirus UL47 is a component of the tegument, which is a protein layer surrounding the viral capsid. UL47 co-precipitates with UL48 and UL69 tegument proteins, and the major capsid protein UL86.  A UL47-containing complex is thought to be involved in the release of viral DNA from the disassembling virus particle [1].	25.00	25.00	30.40	70.20	24.40	22.70	hmmbuild  -o /dev/null HMM SEED	887	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.43	0.70	-7.09	18	68	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	48	0	0	67	0	893.00	26	92.53	CHANGED	LpclhppLpssoss.hspL+hLhclElsslslpsl.ossplppFLNpLsphsG.tahsFIppahVFYLL+tuThsspphsht..stcplhphLpph............pphsssstsssssshLsNpplLsplppalsphp.....................................................................shpshppssssspsltshRsVEEllcthapshaphhhtshhh.pht.sssohL-pWLhhhatpshh.........tsshsslpshAppLlsp.............ctc.lFsshsssstshlshPhAcpputtIaplFsps..spsssstssPlLuhssspLs.plssphhFhYcallEuLhpspsY..........ssspstlEpFl..............................................scshshhssluspl.pssop...ppphohsslpphpttLhphGLoccsCpsatphlhhp....s....tssssshcthsphhphlspLshhuahFatCLtpaSPTulhtpch+.ILcpspuhtssppt.....................phsh.Ws..hhslhphFhspsPppphpphspulo.sthh+shhahshpcpWshhhhshp...........ttssssshsstsssopp-lp+aCctlph.......G-s..sY.-s..sllppPhFsptFlcphllPplptILssphpctRuhhplRWLllauus.cs..PpLhpl++sLshlYhtlh-Ihctst.............................................uuhtslhDhhp-lhstlpphs.........ssh..ohsssLLppLahtpassshpphlss.lpcalscspsllpshhshsplusslspsphphsspstpVplshts....ppshpl..............slssFpsslpslpppsp-hhstlsphspplpshhhcLh.sllpclpplppH.l.....shs..p.shpplpcthhcshp+hpsltsplssosshph.s+pFstLapssLlslthlpclLshs..cppssspshl-uhs.shsptssss.s........LsccslptLpchhsphh....psspsss...sslc+paosshchsthsls	..........hpclhcpL+tpsss.tttLphl.plEluulsspsl.oustlppFLstLsp.sG.haFsFl+ppsVFYLLppuTlpssppsL...sAcplhppLpch............tpttssssstsp..shLsNtp..sLsthpphlpplppl...................................................................shpplppssstspshsNCRsVsELl-hhYpphhtahhp....h.a.hthppssDopLDplLhhtahashh...........pussssLts.Fpphlcp.....................ptc.hhsshssoshsssptPsucphpshSa+lFstsltsp-ssshhaPllusshohLs..hluPcphFFasGllptLLpppsh..............t.hcph..L...............................................cthschhs.plspplhcsss....pp.hsltclhphhptLhphGLsccoCssYtpMlhhp.............s.......sspps.thls-htpplhpllassahFFhCL.hYSPTF.LFhp+++hILEppcuhlhus+p.....................phptlWsplshNlpphFssphsEc-Fpthscuso..phtRpaLY+clppKWGshhFshp...........ttsssssshsshcslTppDlh+hCthlpl.......u-s..sYsolhshspaPtFsshFhphhllPplppIhshs.sphpuhss.RLLhLhths.clLhPpphpLh+sLl.lYshhh.lhchDt.......................................................usF+slhDhlh-lhstlppls..........tssh..o.sscLLspLhspuhspsltsplsshlpchhpssts.lppalcasplChuLscspsphsp..c...shsVhl.lps.........phshpV..............shspFhpplcplhcpscpltpslptlspcltslhhRlt.plhp-spplspa.........stsp.shpphscshp+shp..+lpslpsplstshpp...sp+.NthhhsulhphhtlpclLspctlcppuhp.sls-Ahuhhppppuhsshs.s......hsp-shph..L+chhcshh.....pss.pss.....shhpphosst-pss.p...............................................	0	0	0	0
+2918	PF04541	Herpes_U34		Herpesvirus virion protein U34    	Kerrison ND	anon	DOMO:DM04381;	Family	The virion proteins in this family include membrane phosphoprotein-like proteins such as UL34, Epstein-Barr and R50, from dsDNA viruses, no RNA stage, Herpesvirales. The family Herpes_BFRF1, Pfam:PF05900, has been merged in.	25.00	25.00	31.60	30.90	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.31	0.70	-5.42	29	132	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	81	0	0	115	0	202.70	29	69.62	CHANGED	shtcphhschs......sllpRlhhlss.usLcsscssss...hspuss.shCshphp....sspsaslEYVh+h...WA.csps.....sPhhhlpNTGluVhlpsFhstPtss....hu.slsstcsNVhLpsscosuluLsDlpchKt.h..uhDhcshpuhlhhpsalp...spspLpFhhhGPcsssRspplLcpshttt....tsctptp.cpstsshpspsttsssts.sss	...........t........hh....slspRIhhlss.usL+ss-sp.....hspsss.uhCsh.hp....sspsaslEYlLph...Wt.cssp.....sPhhhhpNTGluVhlpsFhptPhss.....s.shs..stcpNV.LpsscolsloLsDl-clKt.h..shchsshpsplhhpsasp...sphpLpFhhhGP-ssu+hppLLcclhttt.....hsptptt..hppt.s.tsp..........hst......................	0	0	0	0
+2919	PF04533	Herpes_U44		Herpes virus U44 protein	Kerrison ND	anon	DOMO:DM04376;	Family	This is a family of proteins from dsDNA beta-herpesvirinae and gamma-herpesvirinae viruses. The function is not known, and the proteins are named variously as U44, BSRF1, UL71, and M71. The family BSRF1 has been merged into this.	25.00	25.00	28.90	28.90	23.60	22.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.38	0.70	-5.07	11	59	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	0	0	49	0	205.90	33	77.15	CHANGED	Mu..h.tWh.CCGl..h.FG+ssp.pYcpLs-s...tpss-Rh+tEI-hGLPP.GVplGDllpsppsppoL+QsYLLAV.....QoNpIT-aLcRFDusclPpuCpslVpsQIsKL+ulpslIWNsMlSlAlGslolD-uulpsLLsKpAs-ohuLhEMEKlATAlchD..sossWApEIssllsstssssts......sslhspspsphshs.h..s..................cstph..sst	...............h...................utshs.cYhhLpss...-sp.c-lpshl-.sass.GlssuDLhphs+-s-.slc..aLLtLh....QspphssaLc+ahusp..C.sHs+sssclEspK.pplhpsl-lhhLKLsVGEhsh.s.-.-uLchLL-KFusDQsoLsEhpKlhsLlcMD..ppossah.......................................................hptsstts.......................................................	0	0	0	0
+2920	PF04529	Herpes_U59		Herpesvirus U59 protein   	Kerrison ND	anon	DOMO:DM04374;	Family	The proteins in this family have no known function.  Cytomegalovirus UL88 is also a member of this family.	21.10	21.10	71.40	69.30	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.39	0.70	-5.62	8	35	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	27	0	0	27	0	390.30	40	96.13	CHANGED	PsssWpDuALlhsDGTVtEHchhNusLucLlRRplcs..-s--t....sVauSELulYloGRssRpuSsFSIYWpsHS-llYsLTGlTHCsKIsVECGph.........................................................................usDup..............plY-hP+laLlRspD.ussuPpcVsWstTsshWsp-VsIcsVp..p+sssARshsslh...................P-ltthhhPLLphtsc................................................s-.slFcE+VussYpRL...t.chssss+oppclLp+ClcLAutK+LLLlDGst.LENFFLspVCLYpLGEDs....luEEhlGhLtsRP-c.....uuuuFhLH+cshpsAssLAllLNslac+Q-tLPsl-p........RlDpsD.lssAl+cYYcpalsVphpsLuhApclLstFopphsstsuhshl..sttlslDusVSRpDllpVLRu	........................sstWpDuALlM.sDGTlhEHtFhNssLupLlRR.............hl.s..-t--p..........sVauSELuhasSGRhsRRuSsFSIYWpsHSDLlYALTGITHCsKIsVECGph.........................................................................ssDup..............chY-hPtlYLlRsp..D.ussuPpcVhWstT.sshWspDVsIpsVp..p+hsuARshsssh...................P-lttchhPhlp.hsc................................................s-oshFcp+VuusYpRL.....chsshs+sspclLp+CVpLAuuK+LLLlDssh.L-NaFLspVCLacLsEDp....huEEhlGhLts+s-s....tuuusFhLH+cshpsussLAllLNslacapctLPsl-p........Rl-psD.lssshRcYYcuassVpspslusApclLssao-phsshcuhshl..chhVshDusVoRccLltlLph..	0	0	0	0
+2921	PF03580	Herpes_UL14		Herpesvirus UL14-like protein	Bateman A	anon	Pfam-B_2982 (release 7.0)	Family	This is a family of Herpesvirus proteins including UL14. UL14 protein is a minor component of the virion tegument [2] and is expressed late in infection. UL14 protein can influence the intracellular localisation patterns of a number of proteins belonging to the capsid or the DNA encapsidation machinery [1].	25.00	25.00	68.00	67.80	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.73	0.71	-4.41	12	75	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	36	0	0	47	0	142.40	53	74.68	CHANGED	pRRcRhhLAEs....+hRtplYKpRTL-LlptGVsspDPtFltAFTuA+pAct-hctpl+SstRlpslcp+sptIpt+V-pQssh+tlLsspRRaLsscFhcpLDpsEDslh-pE-pLp-A....p..huss.st.ct....hsp---uLLspWhLpps	....p.tthRRRLAEs....HlRAclY+-pTLpLhREGVoTQDPcFVuAFMAAKAAHh-LEA+L+S+ARLEhhRQ+AssV+lRVEEQAARR-hLsuHRRYLcPuLuERLDAs-D+LADQEEpLEEA..sssh...st....t.......ht.tppsLLh.W.Ltt..........	0	0	0	0
+2922	PF04559	Herpes_UL17		Herpesvirus UL17 protein	Kerrison ND	anon	DOMO:DM04385;	Family	UL17 protein is required for DNA cleavage and packaging in herpes viruses. It has been shown to associate with immature B-type capsids [1], and is required for the the localisation of capsids and capsid proteins to the intranuclear sites where viral DNA is cleaved and packaged [2]. In the virion, UL17 is a component of the tegument, which is a protein layer surrounding the viral capsid [3].	25.00	25.00	25.80	25.40	22.10	22.80	hmmbuild  -o /dev/null HMM SEED	540	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.81	0.70	-5.92	36	169	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	90	0	0	150	0	507.20	22	95.08	CHANGED	M-sHltN-phh........sspsthllHl.llscssLpttslsh.......................spshhspspochpsssts.o..............................Wppl.authh.spsslsshl...........................hGLhlSlPlhs.t.p.....assFshlhLRlsh.....................sst......phh-lhFhYt-Llssttch.tpstph.....................................................................ssss.sssstpsplp..sshp-Ihphhppsst....shst................................................tsshsuhhpssh..................t..t.tpststptsuLEsPuplRGtt..................................t..psts..phhssshsthss.ssshsstWpt..pslslshhpHhhosp.phhVlsYppShshstptph......sslsp.ht.......................tphshhss.h.............shpsEhthlhphtsthhssltpshppp........th..pltQplshpl...........................psppthpplscph.cuhtslhstlsp.......sSullcAsluphstpstt......hhs......................shhLa-htssshGcslc.hspsslshththphh......................ssstthhpphhsGcshta.....lClha.spsLpshlVLPGGFulpuphsh	...................................M-sHlhs-hth........sspsthhlHl.llsppsLtttthsh..............................................ht.hhhps.sphpssstp.s..............................Wpps.Fsthh..s.tltphL..s..........t.h.........p....hGLhhSLslhh...p.....asshsshtLRlsh.........................sst..........phhsl.Fhht-Ll..thch.tcspph...t.t.hth.........ths.t...................................................t.st.ssss.tstlt..p...Elhp..hhppsst............................................................ttshsuhhpsth..................t...tttptsth....hssLEPPuphRhht..................................t.p.ps..chhsts.tt.ts.tst.sp.Wpt..tslplh.hpchtstt.phhVl.YppShhhstchsh......psl.thls........................t.....................shtschthhhphttsshpslhtslppt.........th..pltQhhthpl...........................tpp.hhttlhchh.thhtshhpthst.......poshhpAhhupLstttst.......hs........................shhhh-hhpss.G-sl+.hsps.lshshphpht.....................sststhhhpphhsGc.hta.....lClha.s.pcLpshlVLPGGFuhphpls..................................	0	0	0	0
+2923	PF04544	Herpes_UL20		Herpesvirus egress protein UL20	Kerrison ND	anon	DOMO:DM04384;	Family	UL20 is predicted to be a transmembrane protein with multiple membrane spans.  It is involved in the trans-cellular transport of enveloped virions, and is therefore important for viral egress.  However, UL20 operates in different cellular compartments and different stages of egress in pseudorabies virus and herpes simplex virus.  This is thought to be due to differences in egress pathways between these two viruses [1].	25.00	25.00	43.10	32.70	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.04	0.71	-4.45	16	54	2009-09-11 15:08:44	2003-04-07 12:59:11	7	2	36	0	0	45	0	165.10	32	77.71	CHANGED	GssDahloSuhsph.s.tpPsFo+pVllahhSAllL+PlCCllFhhYYhhossthhhlsuhshTshaYh.pLslp.hhhlYtNl+pDcLPLsssQphlluhlssupslsFhssuhptlFtssplFhhlhssptps.......h................shusshlshhushlYusDulsDuluFhLPRhWsRull+	........GssDhhlSSAhsphss.s.pPsFoppslhahhSsllL+PlCClhhhhYYhhTtphhhhhsshshshsaYh.phhlp.shhlYhNl+pDhLPLusstphhluhhssutslhhhhsAhpthFtsstlFhhlhssptp..h.....h................shussshshhAhhlYusDslsDshsFhLPRhWsRslLp..	0	0	0	0
+2924	PF01646	Herpes_UL24		Herpes virus protein UL24	Bashton M, Bateman A	anon	Pfam-B_946 (release 4.1)	Family	This family consists of various herpes virus proteins; the gene 20 product, U49 protein, UL24 protein and BXRF1. The UL24 gene (product of the 24th ORF) is not essential for virus  replication, mutants with lesions in UL24 show a reduced ability to  replicate in tissue culture and have reduced thymidine kinase activity as the UL24 gene overlaps with thymidine kinase [1].	18.90	18.90	22.20	22.20	16.70	16.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.01	0.71	-4.82	16	158	2012-10-11 20:44:43	2003-04-07 12:59:11	11	1	93	0	0	143	0	174.40	32	65.99	CHANGED	LphLPttRt+AGpRsHhRhY+pLhphh...shsplttaLs.........h.tPsspp..sclpLaFEVsLGpRlsDClhllpss.....tphhCallELKTChhss....shposo+psQRtpGLpQLpDoschLpphsP..sGspthplsPlLlFhuQRuL+slhlcp..hsspplpsssstLtshltsht-hssptpl	............................l.ptRhpsGhRsHhchY+tlhp.h...shsthsthLs.............h..h..shhpt.s+hpLhaEVsLGpRhPDClslhp.s...........ps...........ttshChllElKTChhsu......shpsso+ptQhspGh+QL+-ohphlpphsP....sGsp.hhhlsPhLlFhsQ+uL+s.hspp..hhspplpsshsslhshLtphp-hsl.h..h.......	0	0	0	0
+2925	PF02760	HIN		HIN-200/IF120x domain	Bateman A	anon	Bateman A	Family	This domain has no know function. It is found in one or two copies per protein, and is found associated with the PAAD/DAPIN domain Pfam:PF02758.	22.70	22.70	22.90	38.00	20.50	22.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.99	0.71	-4.89	10	158	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	24	18	53	201	0	163.60	54	42.91	CHANGED	pccPlpVMVLKATcPFpYEosEpth+pMFHATVATcTpFF+VKVFNhsLKEKFltp+lIsIScYacpsGlLEINEASoVSEAsssQshEVPssII+cApcTPKIspLpcQsSGslVYGlFhlpKKpVppKshhYEIpDcTGsM-VVGsGchaNIsCEcGDKLRLFCF+L+	..ppsPhpVMVLpATcPFpYEs.Eptp+pMFHATVATcopFF+VKVFNhsLK-KFhsK+IIsISsYhppsGhLElpc.sSoVS-ssssQphEVPpslIcpAspTPKIspLppQ.spGohV.GlFhlpKKsV.p.p..c.sshYEIpD..sTG.pM-VVspGc.hpsIpCEEGDKL+LhCFcL.....	0	5	5	10
+2926	PF03369	Herpes_UL3		Herpesvirus UL3 protein	Mifsud W	anon	Pfam-B_2492 (release 6.6)	Family	\N	25.00	25.00	64.70	64.60	17.40	16.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.20	15	263	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	36	0	0	58	0	62.50	88	73.24	CHANGED	VsFDTLFMVSSIDELGRRQLTDTIRKDLRhSLAKFoIACTKTSSFSus.sspp+tRtt...sp+sspSNKSLQMFlLC+RAHAt+VR-QLpuVIpuRKPRKYYTRSoDG+o+PsVPVFVaEFsAs-PVhLHRDNVlts	.................................................................................................RKPRKYYTRSSDGRLCPAVPVFVHEFVSSEPMRLHRDNVMLA.	0	0	0	0
+2927	PF02718	Herpes_UL31		Herpesvirus UL31-like protein	Mian N, Bateman A	anon	Pfam-B_1786 (release 5.5)	Family	This is a family of Herpesvirus proteins including UL31 (Swiss:P10215), UL53 (Swiss:P16794), and the  product of ORF 69 in some strains (e.g. Swiss:O36420). The proteins in this family have no known function.	25.00	25.00	56.40	56.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.67	0.70	-5.70	30	120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	80	0	0	108	0	262.80	32	85.44	CHANGED	pup............stss+psppppthh........hshctaFshluppP-hElchLRpMssPIssocslsLPasLsp.hsscsCLsLSshGap.shGusCssCpssupsphsp.................-hsulhLAFlpQlsslhpa+sFahSlls..................tu.chl+pslsQPpLFasYalL+ssshcshslha......tsssshltMYllF.pspslHlspchlcpLhsss.ssYplssDlhpssalLsl....phcp.s...........ssslsssslhcKls-LshssElttEap+hhshhsch	......................................ttstttsts........ths.ptp..p.ttht............+.ph+thashhtppPs.Elphl+.hphPIstppslsLPFshpp.psscsCLsLSshG.p.s.tusCssCtsssp.t.st.................p.sshhLAFlpQhsslhcaRsFhhSlht......................sp-lLctshsQPpLFahYalL+sustc.s.lha.......ssputhhMallF.pspslHl.pchIcphLsAs.ssYclshclhpspaVLsVppp.t.ps.o.............ssplsssslhpKls-lshss-lh.cap+hhshhp-...............	0	0	0	0
+2928	PF03581	Herpes_UL33		Herpesvirus UL33-like protein	Bateman A	anon	Pfam-B_1115 (release 7.0)	Family	This is a family of Herpesvirus proteins including UL33 Swiss:P10217 ,UL51 Swiss:P16792. The proteins in this  family are involved in packaging viral DNA.	25.00	25.00	45.60	45.30	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.48	0.72	-4.08	29	92	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	74	0	0	76	0	77.30	38	58.70	CHANGED	tlhFEsll.Pp-h-llhPTsDA+LNaLsasp+Luuhlpatpst....................tssCsHuplLppKp-thssllsKhLDlcpILcs	...lhFEshl.Pc.h-llhPohDA+LNalshsp+LAuhlcaspst....................sssCsH.uplLppKpchhsullsKhlDlctILc.....	0	0	0	0
+2930	PF03586	Herpes_UL36		Herpesvirus UL36 tegument protein	Bateman A	anon	Pfam-B_3425 (release 7.0)	Family	The UL36 open reading frame (ORF) encodes the largest herpes simplex virus type 1 (HSV-1) protein, a 270-kDa polypeptide designated VP1/2, which is also a component of the virion tegument. A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells [1]. This family only covers a small central part of this large protein.	20.50	20.50	20.60	21.10	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.59	0.70	-5.29	11	176	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	33	0	1	127	0	213.20	54	10.60	CHANGED	tpc-tWtuslcAsLccsEs+ucFDAsElsRLc-hAsstGYcst...ch+ppAEpslsApApsspsAl-uVhuFNPYuspNpt......pshhPPlusL+sloWhDuFssAAPhYspLF.Glss-sLhpLh+IutulLctA.sAssGp..lDYapsVspluuDLttlPpLsKYVDFYp+GascF.shhu+LsphRu-shpAsGshshElutAhEplstlR.sPpsA++sL-tGVplhlPStsslhshsstLcc.DhspFcsTAYtEhh	..............................h...ptWhtsl.AsL.thEstthFsusELsRLRDhAAsuGaDh+...slhspAcQVVAAsts..TusoALDTVF+aNPYTPENss........lsPPLAhL+ulTWhDsFulsAPsaTsMF.GVslEGLhhLhRIpuslLhoA-solsGh..ssYhthlhchutsLhtlPtLttaVsFa.puatpa.t..stlpth+tchh.h.sth.h-hthA.Ephth.+.s.tsAt.hlctG..l..su..hlhth.t.hpp.c.p.h.tTAYtc...............	0	1	1	1
+2931	PF03277	Herpes_UL4		Herpesvirus UL4 family	Mifsud W	anon	Pfam-B_4461 (release 6.5)	Family	\N	25.00	25.00	50.20	50.10	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.06	0.71	-5.06	15	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	35	0	0	68	0	184.80	44	88.16	CHANGED	sThIAYoLpsl+sssshslPchEQllCuh-uGoRulsVGscsRCDpLPsGsllIQHsPlGTLlsVDsts-FCSYthhh....ttppstshpshssshhVhPFsoWsssupspplpSsouGlLTl.hhsssolaITlTlYGps...st.sssh.h.spssspssssshst..ts...............................................tDlLspsl+Euclps	..pThIAYSLpps+uShs.sLPDstQVVpsFEhGTRuIhV+GcpRpD+LPpGsVVIQHTPlGhLlllDCpsEFCuYtFhs....pcpppph.puh-uphaAhPFsSWVuSuRscssRSsouGlLTV.lWsscoIYIThTIYGssspt.sssssps.stssss.spsssss..sup.....h.hQss.........................................tDLLsElLREhpLps.............................	0	0	0	0
+2932	PF05072	Herpes_UL43		Herpesvirus UL43 protein	Moxon SJ	anon	Pfam-B_5928 (release 7.7)	Family	UL43 genes are expressed with true-late (gamma2) kinetics and have been identified as a virion tegument component [1].	24.90	24.90	38.40	34.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.16	0.70	-5.71	9	65	2009-09-11 05:23:58	2003-04-07 12:59:11	8	2	29	0	0	61	0	353.40	33	91.23	CHANGED	GsstssptChtChhssspulhthuhpsulhsuulhll.hhppshAhsshhhssIsshhlsh.hRhshphh-hlshlG+shQhlsshsuulsWslu........stsh.ts.phslssuhhshslhus.lt.apaVshAsusshpa+suhLshssGsllGloshhhslps.shhuhshslls...hssspD....sussLpsTCaY+hsRttslps.scLG+....uhhssss-ssttcEcs.sutsshcsphsh...lhlshVhhlssPhlhslp+hh..ttusphpsstsshhsshsGalluhulp.Lslh.s.pcsLhpsllhhashhtshulsLsshGh.hGsslhLAuusuhuhhsslslRppspshp.....+LAAuplsKslhsslh.....sshhlC	........................Gpsssspsp..lsCshshspuhhtlhlpuAslshshsll.h.ptshA.ssssshhslushhLuh.hRss.shscshsplhthlphhuuhsAhlhWslu.............hshs.ts.phulssuhhshlVhAs.lashahl....ussshFhsshhhlsuGhhlGsSAthh.ls.s.uuhuluhulls...hssspD....As.shccsChhhtsctss.h+sspD.tR....u..ssss..s..ss.........sp+ppsssusplh.sthst...lhlslVshlussslhshsthh..upusshsshshhstshluGHlssuhsp.Ls.shs.shcLocsllhlHsslplhslsLshts.tl.ulhhhLuuAshluLspslslR+Rh+ttc.....+LAAo.hsRuLahslY.....luhhlC.............	0	0	0	0
+2933	PF03387	Herpes_UL46		Herpesvirus UL46 protein	Mifsud W	anon	Pfam-B_2545 (release 6.6)	Family	\N	25.00	25.00	101.70	101.50	15.50	15.20	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.31	0.70	-6.27	11	70	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	33	0	0	71	0	437.90	44	65.51	CHANGED	suhpshS.pslhpcRhctGCL.........LPsPpslhsuAVtALc-ts-slhPssLhuspRpssLhsh+sNpVPESlIlsshusDsps-Yh+pYsushppsLscttLotsslhRslhspYW+YLp..tooGs-lsssstsssss....p.osllLhhsshs.K.Lu+pPFKpcsssusYtsshstL+-AhctlQ+YMYYMRPsDPhssSsDTslRLpElLAYssThYpWhlWhhDslDupVlRpht.h.phstGP.RsshsP-slFtRHLcsGPulsoGo.ussh.............hLssssuslLusLl+luslWppspW+usspG.sssAIVAAVELlollHHHhQYLlNhshsGYssWlcGGlpssaLpuALRuQpRFp+hhG.............pLhPTMospSWushEpuspsWFchAlA+Sllsa...GsPTtaYpslLpsl.........ssP.psphsspsss............stssts.hpstputPPsssu	..................s....t.s.tGlsERRlhsGCL.........LPTPpslLuAAVuAL+p+oD-hpPuhLpss-RustLuuppH.NsVPESLIVcslAuDs+hEYlR+YuuAAppsLu-scLouutlpRulLspYWKYLp..ssSGl-VP-cssscscs......SltlLLpPTlusKhLuRsPFKstussApYsAslAsLRDAl+tlQpYMaFMRPsDPopPSsDTulRLpELLAYVusLY+WA.Whl.TsDt+VC++Ls.ssR+hhsh.tuspuPs-hFuRHL-pGPosooGS..hpsh.............sLpAulucVLupLpRLusLWpsuchpuGTaG.sscslVusVEllSlVHHHsQYIINhTLsGYssWussuLsNpYLRAAlcuQcRFs+hsu.............sLFPTMousSWAcMEhSl+uWFstALAtsLLpp....GsPoh..HYcslLchl........uSp.sphptussPss....................................st.............................................	0	0	0	0
+2934	PF03362	Herpes_UL47		Herpesvirus UL47 protein	Mifsud W	anon	Pfam-B_2182 (release 6.6)	Family	\N	25.00	25.00	163.40	101.80	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.28	0.70	-6.16	13	117	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	34	0	0	101	0	414.00	36	60.55	CHANGED	cshcEcphhctpss.hs...hstW.u..sssastGsMYsusPs..csthsa+RshpQutALhh+lstsuLpsulssp.thostcAlhFLlDAslRlAtNsahsupp..................hhtthphhoslp.lPtusus.lLpssshpsP..............tpGPpAAlhRuuhGuLsYWPELRssLsc.schhlRYAtsth.hAEsaLLARhp.utpsuhsspEhc....hLushlTLhsllActslpaLhsusuthLp.scssctshptsptststptlPlsS.tLhsAEstsLushsusph.htssuLutshssuYhAlR....oAhTsLhh-au.t.....sptptcsscthssAhLussllLQRLLGHhNhlLspLstAAhhGGpsl.sVhptThtcYphLhpsssPLYp.sols-Fhc-R--AMcpLcLcs......ssu.sPhsuhchl....lp.tht.ssL-slh....shs.ssshshLGshVsls-hltca+chlhuc	........h.h..Ep.hh......ht....stW.s..t...s.GtMahtt.s..s.hsh.hpsltQupAlhaphhhsshhsthspp..ho.spuhuFLhD.AslRluhNshhhupp.................pshthhp.hhh.stLtslsttuss.lLpssthshP..............ppGPpsAlhRu.hGuLhYWPtlRhhlscssp.hsRYAstth.lA-hhLhuRhp.shpsphsspEtt....hLuphhslhsshutthlpWlphssuhhLt.sh.s+sAahsVstp..ahhlPlsSshLssAEstlLGclsssss.hts.ALssshhsuY.AlR....TAhoshhlcaA.......cstcpspschhspAhLussLlLQRlLGHANhlLshLstAAhhGGhsh..hlhpso.ctYspLhhAssPLYsppThscFW+DhcsAhcplslcP......sos.sP+sshRhl....Ic.shhh.sL-sh.....Pt..........Pp.Vcls-.h.paRp.lhG........................	0	0	0	0
+2935	PF04823	Herpes_UL49_2	Herpes_UL49; 	Herpesvirus UL49 tegument protein	Mifsud W	anon	Pfam-B_3850 (release 7.6)	Family	\N	25.00	25.00	27.60	112.50	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.11	0.72	-4.02	13	97	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	34	0	0	91	0	96.10	58	33.54	CHANGED	sRAsPGsp...slstuK.luFSssPsosousWpusThuaN++lFCtAVutVAttHAptAAtuLWDhssPRoNE-L-chLptAsI+ITVsEGhsLlptAN	..........s.........tuhu++LpFSTAPsoPoAPWsspssuFNKRVFCAAVGRlAAhHARhAAlpLWDMspP+TDEDLs-LLshssIRlTVCEGpNLLQcAN..	0	0	0	0
+2936	PF04540	Herpes_UL51		Herpesvirus UL51 protein	Kerrison ND	anon	DOMO:DM04380;	Family	UL51 protein is a virion protein. In pseudorabies virus, UL51 (Swiss:Q85227) was identified as a component of the capsid [1]. In herpes simplex virus type 1 there is evidence for post-translational modification of UL51 [2].	25.00	25.00	33.60	33.50	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.66	16	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	33	0	0	50	0	160.80	50	66.65	CHANGED	lCGhtstscc..pYE.lpsss..sss.s.hRLpEAlssVNsLLPAPlTlEDsltSADssRRLV+ApuLARTYpAC.......RNLECLu+HpsutsssuL-AVVpsHhtsspRlADTChAuLhphYhSVGAs-tsTDshV-QAIRhsAEo-lVMuDVAllE+ALGlsupssssu	.........lCGhttpspc...pYE.lpsus..ssstu.hRLpEALssVNuLLPAPlTLEDsltSADsTRRLV+ApuLARTYpAC.......+NLECLuRHpsut-sPsLDAVVtsHtpss+RLADTChAulhphYhSVGAsDtoTDshV-QAIRhsAEo-VVMsDVAllERALGLsst.t...sh...	0	0	0	0
+2937	PF04537	Herpes_UL55		Herpesvirus UL55 protein	Kerrison ND	anon	DOMO:DM04378;	Family	In infected cells, UL55 is associated with the nuclear matrix, and found adjacent to compartments containing the capsid protein ICP35.  UL55 was not detected in assembled virions. It is thought that UL55 may play a role in virion assembly or maturation [1].	25.00	25.00	26.40	25.40	17.80	17.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.48	0.71	-4.86	7	43	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	31	0	0	35	0	164.90	38	89.39	CHANGED	ttsh.sshp.stlsslhpVlsPLsl-soapSsp.spcpPsssshhlssRoYhlRAsCppssclHAFFhGLupcss.shs..hsslpshsplhNpp.hhpchtshp...phCcuPFStATlhDsl-ss.....shsIpGlsaHCHCcs.FSh-CWtuA.tAh-+lsshs+shpshst	........htss..sshhhphPslopVssPhsLssoWpupp.s.......hcssps.......ssuslssRoYllRAsCsossslHsFFaulhc-tstphs..hs-LcsFscllNp..llpELtsc+.stthCssPFSsuTIhDssssut..........phsIsGlsYHCHC+sPFSh-CWpuAsuAhp+ltSlupuhtusp.t........	0	0	0	0
+2938	PF04534	Herpes_UL56		Herpesvirus UL56 protein	Kerrison ND	anon	DOMO:DM04377;	Family	In herpes simplex virus type 2, UL56 is thought to be a tail-anchored type II membrane protein involved in vesicular trafficking.  The C terminal hydrophobic region is required for association with the cytoplasmic membrane, and the N terminal proline-rich region is important for the translocation of UL56 to the Golgi apparatus and cytoplasmic vesicles [1].	25.00	25.00	32.70	29.00	20.80	19.60	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.34	0.71	-4.60	3	23	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	0	0	22	0	193.30	71	84.13	CHANGED	MASEAAQPDAGLWSAGcAFADPPPPYDSLSGRNEGpFVVIDlDTPTDoPPPYSAGsoLlGPlsPsSSG-GEssERGRSRpAA.RAARRARRRAERRARRRSFGPGGL.luTPLFLPEThluAPPDVsuDLlSGLPTYAEAsS........DHPPTYATVsAA........RoTEQPuGuluPsDQPRoQsSGsWRPPpVNSRELYRAQ..............RAARsu	...............MASEAAQPDAGLWSAGNAFADPPPPYDSLSGRNEGPFVVIDLDTPTDPPPPYSAGPLsSVPIPPTSSGEGEASERGRSRQAAQRAARRARRRAERRAQRRSFGPGGL.LATPLFLPE.TRLVAPPDITRDLLSGLPTYAEAMS........DHPPTYATVVAV........RSTEQPSGALAPDDQRR.T.QNSGAWRPPRVNSRELYRAQ..............RAARGS....	0	0	0	0
+2939	PF01763	Herpes_UL6		Herpesvirus UL6 like	Bashton M, Bateman A	anon	Pfam-B_878 (release 4.2)	Family	This family consists of various proteins from the herpesviridae that are similar to herpes simplex virus type I UL6 virion protein. UL6 is essential for cleavage and packaging of the viral genome [1].	22.00	22.00	22.20	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.70	0.70	-6.33	30	194	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	91	0	1	167	0	449.10	31	82.83	CHANGED	htahEILpGchuYscGQslasulRsssshhRQl.sslh+ssLsussY--ltsDWppHhss.......lspRastppptps.thtcpsFpoWppTL+hoLhchlpshls.hlastssss....Ys+YlDWlsslGlVPll+p.....s.......tt.hhpphppthppstppp.ssp.+lhssllppstphlpplhpslsultIs-asclpIhashpppphhsh..hssc+hcshVlhpPlhts.spllFDSPlQRLatElhpCasLpEHAKlCQLLNTuPlKlLlGp+scs......ssp+ll-+l...-ppspsusAtpcLl+Lllslps.+plusITDsV-saLp-sossllDpsplhssststh..........................spssppul+cpVssslh+sLEs.INp.FcTIcsL+ptNcshhp+lpphEspLp+hppc............spsssss..................sspl.s.sshpulptl...hppslh.sosshs-sphVANSFhSQYlPsac-phccLopLWEpElhRsFKLs+lssNQGpElulsYSssoIolLLuPahaslLcltpls.LlscphshhS.pElssslacpSRLpsYlsDlut+a.....s	..............hhFhclLpGphGYspGQslapslRsspshh+Ql.hslhpthLsusshcclhs-Wppahp........h..+ht.ttt.t..thtpphapsWttoL+pollshltsllt..has.st.s....as+YlDWlsslGlVPlhch..................ht.h...h.h..tt......thssphhtpsh.hlhplspshpustlhsascsplahphpptph.sh..hpspchchhVhh.Plhh.....t.ttllFsoPlt+lh.ElhtpptLpcHt+lCpLlNThPlKslhsp+pp.......thtchlphh...pppsptssAtppll+hllNhps.+phhslpDoVcualp-hsspllD.s...hssp.s............................ts.thppsh+s.hhppl.thLEt.lpp.hppIppL+phNtth.pplpphcttLp+httt............t.t..t........................ph.p.sh.tshphh....t.tl..hsh.hs-sthlsNSF.upalPshtp..ccLopLWEpEhhRsF+ltphhssQGtE.ul.YSs.slthhlhPah..llph.pht..lstt.h.hu.tElhtslacpo+hphYlp.lt.h..................................	0	1	1	1
+2940	PF01677	Herpes_UL7		Herpesvirus UL7 like	Bashton M, Bateman A	anon	Pfam-B_1086 (release 4.1)	Family	This family consists of various functionally undefined proteins from the herpesviridae and UL7 from bovine herpes virus [1,2]. UL7 is not essential for virus replication in cell culture, and is found localised in the cytoplasm of infected cells accumulated around the nucleus but could not be detected in purified virions [1].  Members of the herpesviridae have a dsDNA genome and do not have a RNA stage during there replication.	25.00	25.00	58.00	57.70	18.10	16.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.38	0.70	-5.01	33	122	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	82	0	0	109	0	220.00	27	77.39	CHANGED	hshEV+cs.sshslthsssslsshsV....tttlhh.h.t...sshhshcsYhppphspssFtGFshsslsssEDtVpslslsPhllpcRhsla+PpshhcFpLCsll.hLENh..tssosshhhplhshLchlts+.ss.sphsphLhpusphLlsTlhhhath..tshcsphllsphshh+h..Lhp.tpssshsllpsla....t...hpshpLstsspps........hhhcstsuh..hNthass	......hshEV+ps.sshtsthsusslsshsV....stplhhhhps...sphlsscpYhppshspsuFtGFshsslsssEDtVpslslsPhlLpaRhsla+Pcshh-FpLCsLlhhLENh..tpsosshhhplhsaLphsts+.ss.pphpphLhpusphLlsThhahhth...shcsphllsph.hhch..Lht..tsss.sllpsla....t.s.tsshpLstsstps...............tthhps.suh..hs.hh..s...............	0	0	0	0
+2941	PF03554	Herpes_UL73	gpUL73; 	UL73 viral envelope glycoprotein  	Finn RD	anon	Pfam-B_3001 (release 7.0)	Family	This family groups together the viral proteins BLRF1, U46, 53, and  UL73.  The UL73-like envelope glycoproteins, which associates in a  high molecular mass complex with its counterpart, gM, induce neutralising antibody responses in the host.  These glycoprotein are  highly  polymorphic, particularly in the N-terminal region [1].	19.60	19.60	20.20	20.00	17.90	19.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.95	0.72	-4.16	16	253	2012-10-01 21:33:21	2003-04-07 12:59:11	8	2	54	0	0	165	2	89.80	51	77.14	CHANGED	hhshsstshsstssspspssssssspspssFYshsCsADTYt.oLsSFSSIWsllNslllhsAsslaLpYhCFp+Flsshs+	...........................................hso.hooT.STTSTKsoSTTHDPN.VM+tH.spsDFYcAHCTSHMYELSLSSFAAWWTMLNALILMGAFCIhLRahCFpsFsspTh.......	0	0	0	0
+2942	PF01802	Herpes_V23		Herpesvirus VP23 like capsid protein	Bashton M, Bateman A	anon	Pfam-B_1435 (release 4.2)	Family	This family consist of various capsid proteins from members  of the herpesviridae. The capsid protein VP23 in herpes simplex virus forms a triplex together with VP19C these fit between and link together adjacent capsomers as formed by VP5 and VP26 [1]. VP3 along with the scaffolding proteins helps to form normal capsids by defining the curvature of the shell and size of the particle [1].	25.00	25.00	26.60	26.60	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.63	0.70	-5.38	32	501	2009-09-11 06:10:29	2003-04-07 12:59:11	12	1	91	0	0	208	0	163.90	62	98.31	CHANGED	tplhlslss+Loss-lupLQcphGpllslssh++hhslpsluLpshh.tssssDalplhshh+cphhAllpcVpsspllhshlshG....psht.l+NT.uP.FphssGDtlsllPPlFst.pssl.pLpSssh-LlFPhsVPpsLApEllt+llshslhuhststp..tsshsch...hpslpYpG+pasLs.shpptss.s.ssl+sLslshshhss.ustllhsllss.Lshpspc.hlsthhplhsspp.................hphhc.sshsh.pDhsR...............lsuahohhppLuslhshpshhpVssas.ssspssss......h	........................................................................................s.....sht.lpNs.uP.hphppss.lsllPPhFt....t........sp.......h.hL-SNGFDLVFPMVVPQQLGHAILQQLLVYHIYSKISAGAPsDVNMAELDLYTTNVSFMGRpapls...........................................................................................................................................................	0	0	0	0
+2943	PF03327	Herpes_VP19C		Herpesvirus capsid shell protein VP19C	Mifsud W	anon	Pfam-B_3451 (release 6.5)	Family	\N	25.00	25.00	30.10	53.50	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.55	0.70	-5.52	31	121	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	83	0	0	106	0	283.70	27	73.81	CHANGED	shsp..shhschhhttttlsptp.shus.hh.hhpsss...suhcslllSlshlshs....h.st..ssusul+shltshYssp...upLtphssslpthlpsp.a.HchlpslGsllpslspshlsplTsVh+Gsshstpsspht.....slh.......lPs-hFlDlDt.h.....................ttspsuhphlYlshlYspph.pcttspla.hhpSttscpslhshLchhaushRtpph.......................................................slpspsshsphhaGAhs+LGhhssssshp.....psphphpussLPVVplpshhsc.hGsWp.h	..............................tpp.stchh.shtpltptpshus.....tpsss...susRshllSlsFLshs....h.sp..suusAlRstltu.Ysss.htscLschstsLpshlcs+sa.HchlphhGsLlphlopstlsplTsVspGsp.uscsspss....sslh.......lPushalDLDtph.....................thsssustalYLlhs.Y.ppct.scptsplY.lhpSp.hs.psltssLcthFuchRhspshp.....................................................clpu.psstpsssauAhscLGhhsps.sshp....+sphh.tusslPVVhl-shshc.sG.sWpth...........................	0	0	0	0
+2944	PF01521	Fe-S_biosyn	HesB-like;HesB; 	Iron-sulphur cluster biosynthesis	Bashton M, Bateman A, Wood V, Mistry J, Eberhardt R	anon	Pfam-B_518 (release 4.0)	Family	This family is involved in iron-sulphur cluster biosynthesis [3]. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins [1] [2].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.35	0.71	-4.13	98	8207	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	3441	17	2003	4486	4099	102.60	30	78.59	CHANGED	Mplsl..TcsAtpplpphhss.ppt.........lhLshcsGs........th.Cuh.uspaplhhls..cs......ssh-hhlc.ssshslhlcs..hstsaltpshslDas.thtshsLp.ssss.hlssssslsc	........................................lpl..T-.uA.sp..+lppllsp.psps...........................tlR.lhVpsuG............Cu..GhsYshshs.c...cs...................................spsD.h..s....h.......E.....p.....p..........G......l...p...l......h..lDt..hSh.aL...s........G..s.p.lDa.s.c.s.h.h.sp.t.Fp......hpN.P.Nu.p.s..p.CGCG........................................	0	581	1176	1615
+2945	PF02444	HEV_ORF1	HEV_ORF2; 	Hepatitis E virus ORF-2 (Putative capsid protein)	Mian N, Bateman A	anon	Pfam-B_1896 (release 5.4)	Family	The Hepatitis E virus (HEV) genome is a single-stranded, positive-sense RNA molecule of approximately 7.5 kb [2]. Three open reading frames (ORF) were identified within the HEV genome: ORF1 encodes non-structural proteins, ORF2 encodes the putative structural protein(s) [1], and ORF3 encodes a protein of unknown function. ORF2 contains a consensus signal peptide sequence at its amino terminus and a capsid-like region with a high content of basic amino acids similar to that seen with other virus capsid proteins [1].	19.70	19.70	21.60	21.60	18.30	18.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.68	0.71	-3.88	3	266	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	12	0	0	229	0	81.00	74	96.04	CHANGED	MGS.PCALGLFCCCSSCFCLCCPRHRPVSRLAAVVGGAAAVPAVVSGVTGLILSPSQSPIFIQPTPSPPMSPLRPGLDLAFANpPuHLAPLGVTRPSAPPLPPVVDLPQLGLRR	.Mt..PCALGLFChCSSCFCLCCPRHRPsSRLAsssGGAAAVPAVVSGVTGLILSPS.SPIFIQPTPS..h...pPGLELALsspPs..AP.G.................................	3	0	0	0
+2946	PF02455	Hex_IIIa		Hexon-associated protein (IIIa)	Mian N, Bateman A	anon	Pfam-B_2076 (release 5.4)	Family	The major capsid protein of the adenovirus strain is also known  as a hexon. This is a family of hexon-associated proteins (protein IIIa).	25.00	25.00	47.90	47.90	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.58	0.70	-5.81	13	134	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	100	1	0	130	0	481.10	62	87.16	CHANGED	KVLsIVNuLl-spAIRsDEuGtlYsALLpRVu+YNSsNVQoNLD+LlsDV+pulupp...RhhcsssLGShsALNuFLuoLPusVpRGQENYsuFluALRLhVsEsPp.oEVYpSGPsaalQsuRpG.lpTVNLopAFcNLpsLWGVpssstc.psslSSLLTPNTRLLLLLlAPFT-usolS+DSYLGaLlTLYREslusu.clDEcThpEIspVuRALGs-.DsusLpuTLNFLLTNRpp+l.PssaoLosEEEpILRaVQpuluLhlhp-sts.sosALDpsutsh-PSFYuuNRsFINRLhDYhcRAAAhsPsYFpphlhNP+WlPPsGFaTGsa-hP-...-u..FhWDcscs................phhcccss-cpscstss....sssssutPuS.hsphs........................................uphspshhsGss-.....lhtPtps+N............h.Nssl-pLlDthuR....W+Thtp-.t...............++.+.tt......sc-ssucpsshhchtGsG...........tNPFAHL+P..+u...pha	....KVLAIVNALsENKAIRPDEAGLVYNALLERVuRYNSoNVQoNLDRLVTDVREAVAQRE..RF.+sssLGSLVALNAFLuTQPANVPRGQ-DYTNFlSALRLMVoEVPQ.SEVYQSGPDYFFQTSRQG.LQTVNLoQAFKNLpGLWGVpAPlGD.RuTVSSLLTPNSRLLLLLlAPFTDSGSlsRsSYLGaLLTLYREAIGQA.pVDEQTaQEITsVSRALGQp.DTsSLcATLNFLLTNRpQKI.PsQYuLoAEEERILRYVQQSVuLaLMpEGAT.PouALDMTARNMEPShYAuN.RPFIN+LMDYLHRAAAhNs-YFTNAILNPHWLPPPGFYTGEaDhP-s.NDG....FLWDDlDs................thh.ptph..tcc..tsts......sstts..stsus....hPSLst.hs.stSst......................................................GRloRPRL.GEpEYL..NDsLLpP.RtKN............hsNNGIESLVDKhsR....WKTYAQ-pR-..ts.............t.pp++pppth........---DSADDSSVLDLGGoG...................sNPFAH.LpP+h.h...h...........................................................................................................	0	0	0	0
+2947	PF00349	Hexokinase_1	hexokinase; 	Hexokinase	Sonnhammer ELL, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF03727.  Some members of the family have two copies of each of these domains.	20.20	20.20	20.50	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.36	0.71	-4.99	14	1806	2012-10-02 23:34:14	2003-04-07 12:59:11	16	20	455	60	944	1749	11	195.20	35	42.73	CHANGED	pshhcplcchhptFplosEpLpclsc+FhpEhcKGLs..+csss........l.MlPsaVtshPsGsEpGDFLALDLGGT..NhRVlhVclsGsp..ph-hppppYplP.......cclhpupu...cpLFDaIA-ClpcFh-cht........pspsLPLGFTFSaPspQsulspuhLlpWTKGFch.....sssEG+DVVsLLpcAIp+Rshs.lcVVAllNDTVGThhussYs-	...........................................................t......lpph.t.h..p..ls..pp..p....Lhplhpphhp.-h...ppGLp......pcs....ps..................................lpM.lPoa...Vp...s...h...Ps..........G....s..........E.p.......G..p.a.LA.LDLG..GT..NFRVhhVpl..pspp..................sh.c.h.p...p......p......h...a.s...lP..........................................pcl.h.p.Gsu.................ppL..F.-aIApslsc..Flcp.p.t.h.............................p.....t..p...pls..L.GFTFSFPspQss....l..s.p..Gh.Ll.pWTKGFph.....................s.s.s.....G..c..D..V.Vt...h..L...p......c..A.....l......c+......+......s....................................................l.......cl.s.A.l.lNDTVGTh.hussYp..................................................................	1	201	397	678
+2948	PF03727	Hexokinase_2	hexokinase2; 	Hexokinase	Sonnhammer ELL, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF00349. Some members of the family have two copies of each of these domains.	21.30	21.30	21.40	21.40	19.60	21.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.45	0.70	-5.17	15	1869	2012-10-02 23:34:14	2003-04-07 12:59:11	11	20	457	61	998	1816	6	217.50	34	49.64	CHANGED	psclGlIlGTGoNuCYhEchppIptlcG.........spupMsINsEWGuF.DstpLs.sRTcaDlslDcp.SsNPGpQtFEKMISGhYLGEllRhlLlcLscpGlLFc.....Gptss+Lpsshhh-TphlScIEsD.pcsLccscslLpp.LGlpsTss-phll++lCclVupRAApLsusGlAAllp+....RGhcthpsslGsDGSVYcpaPpFpcth..tpsl+-Lhsc.....s-..lshl.uEDGSGtGAAlluAVAt+	........................................................stlG...lIl.........G..T.GoN.As.Y.hE.ch..p..s..l..t..h.hps............................sps..p..M.slN.hEW...GuF....Ds...t......h..t......tTcaDpt.....lDp............t.....S.................h....N........P..........G................p....Q..............h...a...........EKMlS..GhYLGEl.lRh.l.Llc.h.h..p..........p....s...h...l..Ft.......................s.p...h...s.......p.....p...L....t.p........h.h.....hp..............Tph............l.S.t.....l.....c.........p.....D.........................p...................s............l...p....p........s.p.p.lL.......p.......p.............l...........s.......l......p......s........o...t........p.......-.......t.h...hl.pplsphlupRuA.p.Lsus.............ul................u.ul...................l...........p.......+.....................................................................p............t........................t.....................................p..........ss..lusDGola....ch...a....PpFpphh..pp..s..l.p...p...l...hs................pp.......lph..h.u..cDGS..GhGAAl.lsA.hs.........................................................................	1	215	418	718
+2949	PF03559	Hexose_dehydrat		NDP-hexose 2,3-dehydratase	Bateman A	anon	Pfam-B_1070 (release 7.0)	Family	This family includes a range of proteins from antibiotic production pathways. The family includes gra-ORF27 Swiss:Q9ZA32 product that probably functions at an early step, most likely as a dTDP-4-keto-6- deoxyglucose-2,3-dehydratase [1]. Its homologues include dnmT from the daunorubicin biosynthetic gene cluster in S. peucetius [2], a similar gene from the daunomycin biosynthetic cluster in Streptomyces sp. strain C5 Swiss:Q53880 [3] , eryBVI from the erythromycin cluster in S. erythraea and snoH from the nogalamycin cluster in S. nogalater. The proteins in this family are composed of two copies of a 200 amino acid long unit that may be a structural domain.	25.00	25.00	49.50	35.60	20.40	15.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.01	0.71	-5.30	79	286	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	121	0	55	284	181	203.50	38	87.16	CHANGED	psss-lhuWlspp+s.ppchpscRlPLscl..su...Wphssss..lsHcoGRFFsV.GlpVps.....ss.pcV..ssWsQPllp.sph..GllulLs+chcGVLHhLhQA+hEPGshsslpLuPTVQsT.uNYsplppusps.aL-hhhsss...s...RVhhDslQSEcGuhFh+tcNR.hlVEs..s--.........lshsss..FpWlTluQlppLL.ppsphVNhpuRTlLuCL	................sclhuWlspp+s.tpphpsc+lPLscl.....suWphssss..lsHcsGRFFsVhGlpVps..........ss.ptV......spWsQPlIptsph..GllulLs+chsGVlHhLhQA+hEPGsh.s.s.lpLuPTVQsT.uNYsphttu.....tps..aL-hhhss....s...t..s..............cVhhDslpSEcGupFh+pcNRphlVEs...s--.......................ls...s..ssFpWlTluQlppLl.p.psshVNh-uRolLuCL........	0	14	41	49
+2950	PF04209	HgmA		homogentisate 1,2-dioxygenase	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Homogentisate dioxygenase cleaves the aromatic ring during the  metabolic degradation of Phe and Tyr. Homogentisate dioxygenase deficiency causes alkaptonuria.  The structure of homogentisate dioxygenase shows that the enzyme forms a hexamer arrangement comprised of a dimer of trimers. The active site iron ion is  coordinated near the interface between the trimers [1].	19.30	19.30	19.30	19.30	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.53	0.70	-6.08	14	1185	2012-10-10 13:59:34	2003-04-07 12:59:11	8	6	998	2	527	1251	479	378.40	34	93.62	CHANGED	pYhoGFGNcapo..EulsGuLP.GpNSPQpssaGLYAEQLSG.oAFTuPRppNpRoWLYRIpPSssHtshh.hc....tphhsssast.ts..sPNpLRWpPh.lP...ppssDFV-GLholsGuGcs..hsppGhAlHhYtsNpSMtscsFa.NADG-hLIVPQpGtLplpTEhGclpVpPuEIsVIPRGh+FpVplh.ts..sRGYlsEsaGspapLP.....DLGPIGANGLANPRDFpsPV......AtaEDpcs....hpllsKapGpLassc.sHSPhDVVAWHGNYsPY...KYDLppFsslsoVuFDHsDPSIFTVLTuPSspsGsAssDFVI..FPPRWhVAE.cTFRPP..aYHRN.....sMSE.........FMG..LIpGtY-AKptG.FhPGGuSLHshMosHGPDhpsFEtAopA...-L+Pp+..ls-.ohAFMFEophshtlocaA.hctpplppsYhpC.WpsLcpcF	..............................................................................................................t...................................P.p.s..h.s.LYtEphsG.osFh.ss.......pohhY+.h.h.s...ss.p....h..........................t....h.......t......s...h....t...t...........tph..R.h...s.h.hs..........t....hsalpGhhs.hsususs.....htpp.shtltlat..ss.p.uM..............s..c.h.Fh..NA.D.GD.Ll.hsppGp..hcl.....tTEh.....G.p..............lp....lpss-hslIP.R.Gh..pa+.............l....ph......s.s...................sRsa.lh.Esh.s....u....thpLP......-h..G.l.G.s..pu...l...h...ssRDhpsP.s...............A.t.a...p....-..c.cs.............saplhsK..hp......G........p.......l.......a..p..s.....p..h..sa..sPh.DVVuW.HGshsPa....................+aslccFpslsohta.H.sPSlasVh............p.s....Ghs.lssFV.....PR.h.s.u-..ps..h+..sP..aaHpN.....lh.S.E...hhG...h.l.pG.sa-.A.p.......t.....p....G...FhPGGhS.LHssh.sHG.P..cstsa..-.t..A.p.u.......p.l..t.....pc....hs-...h...AhMh-Tp.............hslpho.chA.h...p...s.....t....hpt..pYh.t.s.Wt...........................................................................	0	150	295	428
+2951	PF01085	HH_signal		Hedgehog amino-terminal signalling domain	Finn RD, Bateman A	anon	Pfam-B_1424 (release 3.0)	Domain	For the carboxyl Hint module, see Pfam:PF01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.	20.00	20.00	20.70	20.20	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.16	0.71	-4.68	4	383	2012-10-02 01:02:30	2003-04-07 12:59:11	13	11	169	34	136	371	1	126.60	72	36.71	CHANGED	CGPGR..shGRRR.sRKLsPLsYKQhhPNVuEpThGASGhhEG+IpRsSERF+-LsPNYNsDIIFKDEEpTGADRhMTpRCKDKLNuLAISVMN.WPGV+LRVTEGWDEDGaHucESLHYEGRAVDITTSDRDRsKYGMLARLAVEAGFDWVYYESKuHIHCS	..................................................................p.hsh..hKQh.PslsEpshGASG..EG+lsRsst+F+.-.L.ss.NY.NsDIlFKDEEso.GADR.lM.TpRCK-+LNsLAISVMNpW..P....G..VKLRVTEGWD..E......D.G.H..............H...uc-SLHYEGRAVD...IT.T....SDR....DRs...KY...GhLARLAV.EAGFDWVYYES+.sHlHCS...............................	0	33	44	85
+2952	PF00730	HhH-GPD	Endonuclease_3; 	HhH-GPD superfamily base excision DNA repair protein	Bateman A	anon	Pfam-B_854 (release 2.1)	Domain	This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [2]. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases such as Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7 also contains a related domain [1] that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null --hand HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.54	0.72	-3.76	72	13897	2012-10-03 02:11:09	2003-04-07 12:59:11	20	76	4824	121	3791	10642	6191	138.90	24	47.70	CHANGED	lssllspQssspsspphhtclhpth...............h.sscsltphs..pclpplh.................hGhhppKAchlpphuchlhcphtuphspshpphtt............................l.GlGthoushhhhhuhsh.p..hhs..lDstlpRhhpRlhhhpt....s.cphppph.chht.	..............................................................................luhllspQsss.tsl...t.thh.tchhpth..........................................................................PT...sps..l.u.s.....s....s....-clh.p.h.hps...................lG.h.a.s+A..+....s.lp..psuphlhcpasuphPpshppltt......................................................................................................................................................................................................................................hsGlGhtoussshhhuhuh.....hhs..VDspl.t.R.l.h.s.Rhh..hh.pt............s.tp..hcpth.t..........................................................................................................................................	0	1240	2398	3196
+2953	PF03753	HHV6-IE		Human herpesvirus 6 immediate early protein 	Finn RD	anon	Pfam-B_1006 (release 7.0)	Family	The proteins in this family are poorly characterised, but an investigation [1]has indicated that the immediate early protein is required the down-regulation of MHC class I expression in dendritic cells. Human herpesvirus 6 immediate early protein is also referred to as U90.	25.00	25.00	27.00	26.80	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	993	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.99	0.70	-13.75	0.70	-7.07	3	44	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	6	0	0	41	0	565.20	63	91.78	CHANGED	YSoNVEEGASs-FKhllAQSlGNCIQSIGASVKAAMKQEQSDMEDsLINsAGLLTpcRSMLpcLuLEQLSQLININLLSSASSpFVSsYuKMLSGKpLDFFNWCEPRFIVFACDKFDGLVKKVASESR-LLhDLRANMNN-FIKAlKcIFSKAsVsLDspKLNpsATMLLMMAHNKEMSNP-ISNc-FCcKlNpLKQ-LLEuKNEIIEsNuKNMQhhQ-FAIKQMNQIFMDsCDKTFLKIHlNCKNLIoAAKNLGsAVLQSIVICSNEFSWQ+LKspR+pFKITMMsMITcACEpIEolYDDTGLIKPLsSlsIMEGYIshNKNRpSSICDuNlDPSDShlLELtDFDDHGKYSEESS...IESIHEDDDN.............................lsh.ph.-.ppspsssh.sPphsscp.phphhppIcppsluKMYPsTPSPDVPGKSKEs.......cTFlEsSRQoGcEQTSPNCVCT.......ASVTDLGGPDNlKSITGLpSu.......KchLlK+LLDTQsDSVVs.........pTsStpp-hhshS..phppscEhhQ-KsS..............psKpT-s.sG.........................TFoposp.spS.uuI..phs..sK.sp-hEth.pLhshsDGopDNPLISEMLoFGYETDHSAPYESESDNNDEIDYIAssDSusRTNNIHMNNTNENTPFSKSlpSP..PEVTPSKcsaKs-KhsslSpppKsKKRTA......................................KRKsVuhKosKSKKIKoDpLPcsTNVIVIS......SESEDEEDGsNIIcKShLcKsIKSEscSESSS.............ESDDCTSEDNpLHLSDYD............KVINNG.cCpSKGFPSPVFTIPIRSMpG.THGIRsKFVPKKNWLWFMRKTHKVDNCPIHSScKsNsK-DSDsTEAsHCFhNHFVPIKTDDEEY-KENVSYIYsKIQ-SKIDlEsITPTK+LIT-MlMDNFMDLTDIIKpGIsKHCQDLssKYsVlT.TsCEKsLNVsNSQslsTstTQlFDPsVTGNNSsILNIINDTTsQNDENRCTEGTSNsNEKCTs+SDCNSDpTEVFKLDGYPSDYDPFlENAQIY	......SsNVEEGupt-hKsLsAQSsGsCIQSIGA...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+2954	PF03486	HI0933_like		HI0933-like protein	Griffiths-Jones SR	anon	PRODOM	Family	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.17	0.70	-6.00	49	4052	2012-10-10 17:06:42	2003-04-07 12:59:11	9	30	3055	3	923	14035	5432	360.40	33	90.89	CHANGED	hDVllIGuGsAGlMuAhsA..uptGpcVhLl-+spphG+KlhlSGGGRCNlTN..phs.spalsp...Ns+FlpSA.lupFsspDhIshhpphGlth+pccpG+lFsss..pApsllchLlpchcc.tGVpl+hpspVpsl........ttssss.atlps......ssp.plpssslllAoGGhShPphGSoGhGYplAcphGhslhshpsuLVPhshp.tshh.hppLuGlulcslhh.h.............spsthsaptshLFTHhGlSGPAlLplSuah........psstplplDLlPshs..tltphLppp+ttpspptlpss..LsphLPc+lhthlhct..h.t.st..htploppplpplsptl+saslplsGopuhcpA.VTtGGVshcElss+TMpu+tlPGLaFsGEVLDlsGasGGYNhQhAauoGasAGps	........................................................................h.clllIGuGsAGh.hsAhtA..................up..t......G...t..p..V..lll.-..+.....s..........p...c........h........G..............+......K.........l....h........h.......o......G.....G...........G.......R......C.........N........h.......T...N..................t..........h........s.......................s.........p.........h.......l..s......p......................................N.....s.....+......F.....h............h.....S........s........h.....s............p.........a.............s....s...........D............h........l.........s..h.....h...p.p.....h.....G..l.......t...........h..........+............p.......c........s..........t...........G.............p..............l..............F..............s.s.........s...........................p..........A........p.......s.......l.........l...............c...............h.....L...h...p........c.h.c.p......h.....s..Vp.....l.p.h..p..s.p.l..h...sl.......................................tt...p...p....s...t............a......t....l....ps...............................ss...t......p....h....p...s...c.p...lllAoGG...............h....S.........h.....P...p...h.........G...u...os......G.a.c.lAc.phG..hslh..hpsu..sPh.........ph...........p......h............................ptLtGl.u.lp.sl.h.h....................................sptt...h....sh....ptshLF..T....HhG.lSGPulL...phSuah.........................................................p.............s.....................................l..p....l.s....l.h.P...s....h.s.......................l........tphL...p..pt..................p.t.......t...p.s....p.p....t.lps..h..................L...t...................t.....h.........L..Pc+lh.hhh.ph....t.......................l.........................p............tt.....htp.lstp..ph..p....t....L...sptlpphpl..pssGspshcpA.......V.....ThGGVsh....cE........ls..s+...TM..p..u...+h......lsG........L.aFhG..............EllDlsGhhGGYNhphAauoGasAup.s........................................................................................................................................................................................................	0	297	604	782
+2955	PF04588	HIG_1_N		Hypoxia induced protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4868 (release 7.5)	Family	This family is found in proteins thought to be involved in the response to hypoxia.  Family members mostly come from diverse eukaryotic organisms however eubacterial members have been identified.  This region is found at the N-terminus of the member proteins which are predicted to be transmembrane [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.40	0.72	-4.22	59	931	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	520	2	533	819	723	53.40	27	41.59	CHANGED	s+cpPlVP....lGshussuslshuhhsh+.pG..spptSp+hhRhRlhAQuhTlsAlhsG	..............................t.hhs....................lu.hhussss.lhh.u..hhsh........t..pG............stphS....p+lh+hRVhAQuhslssllh..................	0	133	262	402
+2956	PF01355	HIPIP		High potential iron-sulfur protein	Bateman A	anon	SCOP	Domain	\N	21.50	21.50	22.50	22.50	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.70	0.72	-3.85	43	231	2009-09-11 11:04:45	2003-04-07 12:59:11	12	2	165	32	75	216	47	65.40	40	62.29	CHANGED	EsDspApALsYhpDAocs-..ps+a........sGQpCuNCthapup...sssshGsCsl..Fs...GKtVsusGWCsuas	........................EsDspAhALGYptDAocsD...ps+asp......tsGppCuNC.t.hapGp...tusshGsCsl..Fs...GKpVuucGWCsAas..........	0	17	38	55
+2957	PF00713	Hirudin		Hirudin	Bateman A	anon	Pfam-B_707 (release 2.1)	Domain	\N	25.00	25.00	34.70	34.70	20.30	17.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.43	0.72	-3.87	8	20	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	3	141	0	31	0	57.20	81	94.47	CHANGED	loYTDCTESGQNLCLCEGSNVCGcGNKCILGSsGccNQCVTGEGTPKPQSHNsGDFEEIPEEYL	VsYTDCTESGQNLCLCEGSNVCGpGNKCILGSsGccNQCVTGEGTPKPQSHN-GDFEEIPEEYL.	0	0	0	0
+2958	PF02098	His_binding		Tick histamine binding protein	Mian N, Bateman A	anon	IPR002970	Domain	\N	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.15	0.71	-4.39	13	345	2012-10-03 08:47:39	2003-04-07 12:59:11	11	3	20	17	31	355	0	139.90	15	70.32	CHANGED	hsshQDAW+slp.ssscsaaLhhRTacs-.s.hGpshpCVsspspchscsp+shp...........sshtYpN..sss.sphpshstplpshcptsa.shc....Nshphppt.....sspshsh.lhao...Dtst.Csl...........................lpsspsstu.ct..................................CELWh.psphspsh........................................................PssCptsFpths	..........................................................................................h...............tt.hhhhh..p..sh........t.p.......................t..hpCh.hp.h.h.p.h..ppp..tp...h.......................h..h.t.ah.......pp...t....tph.....ph.......ph.th...p.h..h.p.....p.t....sh...sh.............shh.phptt..............ts.shphplh.as....D.h.pp.Chl...........................lp.h...t..t..p.p....s....t.t....................................................CpL..a.htp.p.t..l..p..p..t................................................................s.p.p...Cp.hatt.C...........................................................	0	31	31	31
+2959	PF00977	His_biosynth		Histidine biosynthesis protein	Copley RD, Finn RD, Bateman A	anon	Pfam-B_1089 (release 3.0)	Family	Proteins involved in steps 4 and 6 of the histidine biosynthesis pathway are contained in this family. Histidine is formed by several complex and distinct biochemical reactions catalysed by eight enzymes.  The enzymes in this Pfam entry are called His6 and His7 in eukaryotes and HisA and HisF in prokaryotes. The structure of HisA is known to be a TIM barrel fold.  In some archaeal HisA proteins the TIM barrel is composed of two tandem repeats of a half barrel e.g. Swiss:P05325 [3]. This family belong to the common phosphate binding site TIM barrel family [4].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.34	0.70	-5.09	146	7930	2012-10-03 05:58:16	2003-04-07 12:59:11	16	27	3687	37	2167	8472	6948	229.60	33	89.54	CHANGED	cIIPslDl....ccG.+.sV...cGs..........pshp.ssDPl-...hApta..p..ppGA-cLthlDlsuut...ps+shph..cllc...c...l..scplt...lPlpVGGG....IRoh-slcpl..Lp.tG....s-....+Vslsos....Al.cs.Pcl..lpchucca.GspplVVulD..u+p...........G..............cVhhpGhpcs....oshcsh-hscchpchG..sucIlhTsls+DGThpGhs...l.ch.hcplsptl.s.lP.VIASGGsushc-lhplh.....ptGh..suslsupsh..apGphs	.....................................................................................................................hlIPslDl....c..cG......p......lV.........c.Gs..........................hps.h.p.s...s..DPlp...........hA..ptY....s....ppGA-..c.Lp..h..l...D....l..s..u..up.............ps...+..s....h....ph.....shlc.............p.........l....sppl............lPlpVG.G..G............IR..o............h...........--............l...........p...........pl...........L.p..s.G...........Ac.................+..V..slsos..................Al....p...........s.....P...p.h.............l.pc...h...sc......c....F......G.....s.....p..slVlulDs+t................G..................................hpV.ss.p.Ghpcs......oshcs.h......-..hspch......p..p..h..G.....s..u..c...l.l.l...T..s..h....sp...D.Gs.h..........s..G...h.s..........l...ch..hptl..............sp..t.......s.....p..........l.............PlIASGGsushpc.lhphh.........ptG...s..cuslsupsh..atuph..........................................................................................................	0	713	1441	1865
+2960	PF00815	Histidinol_dh		Histidinol dehydrogenase	Bateman A	anon	Pfam-B_1358 (release 2.1)	Family	\N	19.90	19.90	21.40	20.80	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.24	0.70	-5.84	16	3998	2012-10-02 17:28:28	2003-04-07 12:59:11	15	14	3598	8	1109	3262	5057	401.20	42	91.68	CHANGED	hcphltRsh.cssc.lhptVpsIl-sV+ppGDcAlhEaTp+FD..GVp.l-s...hVst-chpcAhctlsscl+pAl-hAhcNIcpFHtsQh..ptshslEsp.GVhsuphspPl-pVGlYlPGGpAshPSTsLMlulPAplAGsccIVlsSPPs.p.sGphsPplLhsAphsGlccIatsGGAQAlAAhAYG.TEo....lsKVDKIhGPGNhaVTAAKhhVps....tlsIDMPAGPSEVLVIADEsAsPcaVAuDLLSQAEHsssSpslLlTsS..cphAcclpptlpcQlppLs..Rt-.hlppuLs..aSsIllscslpEAl-hSNpYAPEHLhlpscsscp.llsplcsAGSlFlGsaSPESsGDYuSGTNHVLPThGaARpaSGLultoFhK+hTlQplTc-GhcslupsVhsLAcsEsLpAHtpAV+hRhc	...............................................t.....t......s.ssp..lppsVpsIlpsV+pcGDp.ALh-Yop+F.D....p...s..p.....h.........s...s...l..........cV..o..t..p-l......psAh...p...p.............l...s...sc...h+pAlphAhcpIcpaHpt.Qp.....ps...............h...p.............h...c............s....t......s.....G.....lh.hsphhpPlp.......pVGlYVPG...G...p...A...shPSoVLMsul...P..A+lAGV..cclVhsoP.........P......................h...................G.........................ss....tl....L.sAA.p.l.s.GV.sc......laplGGAQAIAALAY......G......T.....E.o.......................ls+VDKIsGPGNtaVstAK.RtVhu..............tV...uI.D.M..AGPSElLVlA...D...p.s..A..s..................Pcal.AuDLLSQAEHss.t.u.ps..l.LlT.ss.........tplAcpVp.ptlpc.Q.L..t.p.Ls............R.t.-..lsp.puls....put.lllscs.l.s.pulpluNphAPEH.Lplps.....p...ss...p..p...hl.sp.lcsAGulFlGpaoPEulGDY.s..u.GsNHVL........P.........TsGsARhsSuLultDFhK+hol...p..h..o.c.pu.....h.pp.l.u.psltp..LApsEsLs.AHtpulplRh.....................................	0	350	717	947
+2961	PF00125	Histone	histone; 	Core histone H2A/H2B/H3/H4	Bateman A, Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.06	0.72	-3.86	64	18172	2012-10-10 12:36:46	2003-04-07 12:59:11	19	47	9743	705	4298	10642	208	64.10	53	50.27	CHANGED	psphthhphsltRlh+plppp..........h+lsupAhhhlppslEshhtclhpcAs.hhupcs+RhT..lts+-lphAh+hp	.......................................STELLIRKLPF.Q.R..L.V.R...E....IAQDFKoD.................LRFQSoAl..h.A.L.......Q..........E....u......sE...A...YL..V.u...L.FE..D.....o...............s..L.......s...A....h..H....A..K....R...................................................	0	1432	2046	3176
+2962	PF01230	HIT		HIT domain	Finn RD, Bateman A	anon	Prosite & Pfam-B_8474 (Release 8.0)	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.27	0.72	-3.46	26	8213	2012-10-01 23:45:21	2003-04-07 12:59:11	18	43	4728	105	2350	6615	3709	96.10	27	65.13	CHANGED	ptEhsupllh-s-hshAFhDhpPpsssHhLVlP+p.p..lsplpshs........ttluplhhhspcluptlph.....................ttpuhphshpsGtpuGQsVhHlHlHllstcph	................................................t..phss.hl.a..c..s...-..h.s.h...A....F...h...D..l...p.....P..h....s..s......G........H....h...L.....l.....lP+p..c......h.s.s.l.t.-.ls...........................tpt...h...s.c....l....h..t.h.s.pc.l.u.c.t.l...t.t............................................................................t....p.G.h.p...l...h..hN....s..s..t..t..u..G.Q..s..V..h..H..lH..hHllP+h..h........................................................................	0	773	1489	1980
+2963	PF00816	Histone_HNS		H-NS histone family	Bateman A	anon	Pfam-B_1651 (release 2.1)	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.19	0.72	-3.48	151	2937	2009-09-12 23:38:08	2003-04-07 12:59:11	16	8	1220	14	554	1580	133	100.10	31	80.49	CHANGED	pcLpphhpclp.........pphppt..cppc.pppsltpl+phhpp..hG..lo...hp-L......................hststt..............sppp+s.sss..KY+pPps.Gp..TWoGRGRpPpWltshh..........spGcpl	..........................................................t.pL.chlccLc...........cptptt..c..hpE..cpc....tlpphp...c...hltt..G..Is...spEL............................................hsssts........tstt+R.sspP.A....K.Yc...s-s.Gc..TWT.G..pGRsPphItpshtptt......................................	0	67	192	380
+2964	PF01870	Hjc	DUF50;	Archaeal holliday junction resolvase (hjc)	Enright A, Ouzounis C, Bateman A, Dlakic M	anon	Enright A	Family	This family of archaebacterial proteins are holliday junction resolvases (hjc gene) [1]. The Holliday junction is an essential intermediate of homologous recombination. This protein is the archaeal equivalent of RuvC but is not sequence similar.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.87	0.72	-4.38	16	183	2012-10-11 20:44:43	2003-04-07 12:59:11	13	2	153	24	103	289	78	92.00	30	64.17	CHANGED	shERELlchLpccG........................FAVlRusuSsuu.......DllAspssh.hLsIElKsopct..+lYl........cp-clcpLlcFuc+F...GupPhlAlKh....scsW+Fhssps	.....................................p.hERELlphLc.c.pG.........................Fu...V..l......R...us...u.Ssus..........................hsDllA..scssh..hlsIE...sKosppp...plh.l..........pp-plcpLhpFucph...........Gu....pshlA.lKh...ttptWhhh....p...................................................	0	26	59	85
+2965	PF02110	HK		Hydroxyethylthiazole kinase family	Mian N, Bateman A	anon	IPR000417	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.57	0.70	-5.20	9	2596	2012-10-03 06:25:16	2003-04-07 12:59:11	10	9	2292	46	490	2628	261	239.80	38	87.31	CHANGED	Lpcl+pppPLVHsITNhVstNFoANsLLALGASPlMuhsh-Ehp-hA+IusA.LlINIGTLss..hcuhhtAscsAp-hspPllLDPVGsGATphRpcssh-LL.phthusI+GNsuEIhuLsGhs.tts+GVDospuuss..s.ltsspplApchsslVlhTGchDhVoDGpp..shslpsGsp..................Lhs+lTuoGChLuuVsAuFhAl...pssLhss.hsAsshYplAu...ppAstcspus.....GSFhsphlDtLhpLstE	................................................................................................................phl+ppsPLlpshTN.Vs.tsh.........sANs.......LLAlGASP.sM.u.p.s.scEs..p..-h.s.p.l..A..s...A..L.l..IN..lG.............T.L.os..p..p.h...puh....ht.As.c.t.A...p.p..s.s..h.P..h.VL.DPV.......u............s.......G.......A.....s..........s...a...R.......p.......c.......h.s........p...cL..L.....s.....h...+.....s...s...........lI.R...G.N....A.SE...Ih....u.L............s...........G..............h..............s......s...........t............u........+...........G.V.........D.....u......s......s....s....s........t..s...................s...l........t.............h....App....h...u..p....c............h.......s.........s.......l....l...l....l..T.G........p........h......D.......h......l....s.........s...u.............pc............s.h..s..l..p.s.Gss....................h.h.s..+...l..T.......GTGChLuAllAuF..h.uht...................ps....s........h......ss......ss.A..s..s.hh.sl...Au......................Eh.A.....s...t...c...s....p.Gs..............GoFpsthLDtLapls.........................................................	0	163	312	412
+2966	PF03865	ShlB	HlyB; 	Haemolysin secretion/activation protein ShlB/FhaC/HecB	Finn RD, Henderson I, Moxon SJ	anon	DOMO:DM07489;	Family	This family represents a group of sequences that are related to ShlB from Serratia marcescens. ShlB is an outer membrane protein pore involved in the Type Vb or Two-partner secretion system where it is functions to secrete and activate the haemolysin ShlA. The activation of ShlA occurs during secretion when ShlB imposes a conformational change in the inactive haemolysin to form the active protein [1]. 	19.90	19.90	19.90	19.90	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.24	0.70	-5.74	2	1287	2012-10-03 17:14:36	2003-04-07 12:59:11	8	9	664	2	267	1255	50	340.50	24	65.32	CHANGED	GDRhVNopLLFPtlcGpPLKLspLDQGLDQANRLQSNpsplDILPGpplGGSVI+LpNQ+tpPWhlshuoDNYGQKsoGRWLhRssAoLDSPhGLSDFVSLNAN.Th-NPspRaNRAYTLLYSlPYGuFTFSuFuSaSpYp.HQpL.ppsVpLaGpTpQhGlRuDYsF.RspcQIDoLshQlTaKRIcNYFpplRL-lSSPpLThhELuhsHLQIlPNGVhSsNLSVEpuhsWhGAtcpP..sp....D.pFTKsKLFsNh.QRhpLhcuTa.hNshFhGQYS+DsLPGVEWLSLTD+sAlRGFspST.SGDNGhYLpNTLShsapLstholTPRlGsDlGplh.+ts.pGWpuuhGlSoGhslpYQpA.lDLEVu+G.lL...oNpspscDPsQlLs+FSYhF	............................................................h.ht..........h..P.hh.t....G.cl....Lsl+-lEQGl-p.hp.Rls...........s.....p.sp.hpl....hP.....u....p.....p...s.....G....t.S......lhl.p.h.p.p..s.c...h....ph..s..huhDssG..p..cs..T..Gchpss..ss..l..sh-N......shuL..s.D.....h.......l..s.........h.....s.......p...s.......h........p......t.....t....t........p....p.....h.....s........p..........s........h.....s.ht.Y..S....lP..a..G..h..a..p.hs..h...h.s..h..sp..a.p....h...t..h...t...s.....t.....s..h.....p..h..p..G..p.o...p..p..h..shp..h..s..+...ll..h...R.st..p.p..+t.....shth....pl..p..+..ps..........ps.......a..l....s....s...s...c...l.p.h..pp....p.p..h.s..s...hph..G.l....s...a...p.p...h..h...s..t...u....h..h.......s..h....slu..a.p....pG.h.s...h...h..G..A....p...t...s.....s....t........t.....t...............................t........s.....p.....h.....p..t...h.ph..s...h...s...ht..h...s.......a...t...l...h...p...p..............ht.a..ss..t..ht...uQa..o..t..s..s..L.hs.t-p.holGuchoVR.GF...c.c.p.s.l.s...u-p.Gha....h+.N....-..L.........s.....h.......h...............s................t.......h.............h.......h.......u.h....DhGt..l................................................................................................................................................................ss.hh.h.hh.h.h............................................................................................................................	0	31	115	195
+2967	PF02794	HlyC		RTX toxin acyltransferase family	Bateman A	anon	Pfam-B_1230 (Pfam 6.0)	Family	Members of this family are enzymes EC:2.3.1.-. involved in fatty acylation of the protoxins (HlyA) at lysine residues, thereby converting them to the active toxin. Acyl-acyl carrier protein (ACP) is the essential acyl donor.  This family show a number of conserved residues that are possible candidates for participation in acyl transfer. Site-directed mutagenesis of the single conserved histidine residue in Swiss:P06736 resulted in complete inactivation of the enzyme [1].	25.00	25.00	25.40	25.10	21.20	24.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.69	0.71	-4.56	29	386	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	293	0	46	249	70	134.70	34	84.55	CHANGED	phLGtlsWLhhpSPhHRcaslu.lttpllPAlphsQatlhp..cs........................shPlAFsoWAhLo.-sEt+alpssppLhsp.DWsSG-+hWlIDalAP..FGc.....sptlh+pl+cp.Fs...sphh+slRhchsuppttplh.ht.......................lp	...........hlGtlshLhhpSPhH+p.asls..hthpllPAIptsQaslhp..cc........................Gh.PlAasoWAhLs.-sEs+aLps......sp......p......Lhsp.DWpSG-.RhWllDaIAP.F..Ga.....sptl.hchhRp.c.Fs.....tph.hRulRhc.sspp.tplhphph...hsh...................................	0	7	23	37
+2968	PF00529	HlyD		HlyD family secretion protein	Bateman A	anon	MRC-LMB Genome group	Family	\N	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.58	0.70	-5.11	44	15364	2012-10-02 20:27:15	2003-04-07 12:59:11	15	41	2231	47	3183	22645	3068	262.60	18	71.90	CHANGED	tsplpspluGhltclhsc-GstVctGplLhplDssshpush......ptpuphttspt...psphhttthpphpshhtspth...............tppptssthtthppshhpsp.....hptsplppuptshpttpsshphs...............sthppstsphtstlss.......tspshhshsplpphhhphppsptt..t.htssspu.hhtt..t.ptlphsptht.....sstslhshl.hpphtlctphtpsphctht.s.pspltsshhsts..hhhpGsssss..h..hhshsssspthts..plhssshsphspthsVclths....ththsspshhsGppshl	....................................................................hpltspV.uG.h.....l..h..p.l.......h...p...-..sp..h.V.....ct......G.p..h.Lh.......p.....l........D.......s.......t.......s...h..pst..ht..........................................pA..p..u.....p....l....t....p....s....p.....t............................t....h.....p.............t....t...........p.....h.....p....p...hp...t.....h....h..t....t....tth..........................................................tpp.t...h..p..p..t.......t...............p.....p.....s.......h...p.t..................................h...s.....p..t.......p..l....p.......p.......u...c.......h.......s...h....t...h.....s....p...s...t..h..hs................................................................sth...s..t......t.t...s...t...h...t...s.h..lps...............................ps..p.h.h.......s.......s.......h...s........p....l......p............h..h....l....s.......l....p....p..s...p...................................................h..p.....u....s.t....s..G..............h.....h..........t......t..........................h.....s...l.......ph.sthss...................ssts..h...h...s....h....l..........h....p...s...h....h.......l...s...s..p.h.......t..p....s.......p......l.......pt......h......h...........s.......s.............p........s...p........l..h....s.s...h.hsp............hh..h.p..u.th...s...........h.........hs.t..t.....s..h.........p...........h..s.................s.........s....h....s....h.......p.....h..s..p.t..h.s.l...p.h.t....ht.......................h..s.....................................................................................................................................................................................................................	0	714	1599	2379
+2969	PF03201	HMD		H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase	Mifsud W	anon	Pfam-B_2929 (release 6.5)	Family	\N	20.30	20.30	22.00	72.70	19.80	16.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.20	0.72	-4.07	13	59	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	31	6	38	60	0	97.90	47	28.43	CHANGED	A-LlusVsDMuSsVTAlshAGlLsYhsssTpIlGAPtchspp.sh.oLpplAuLh-ssGlcsh.cuLsPcsLlsoAcSMphssps..-.LssuLclLEch	..AcllusVsDMGShVTAlshAGlLsYhsssTpIlsAPtchsph.sh.uLpplsuLhcspGlcsM.csLsPcsLlsoAcSMphssht..-.Ls.suLclLcc.......	0	10	18	28
+2970	PF01101	HMG14_17		HMG14 and HMG17	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	21.60	21.40	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.73	0.72	-3.29	18	482	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	149	0	153	417	0	80.60	54	86.60	CHANGED	PKRK.......stssstssKpEPpRRSARLSAKPAPPKPEPKPKKsusKcK............ssKscK.uAKGKc..-ptpptsK-ss...suENG-sKs-E..s.ts-ustspc	.....................t+.........t.sspthsKpE..Pp..RRSARLSA............K.PAPPKPEPKPKKAusKcp.................cK...ssKGKK...tc.ustu..p.ctss...PAENG-sKo-p...s.ts-t......................	0	9	13	36
+2971	PF00505	HMG_box	HMG_box; MaoC_dehydrat_N;	HMG (high mobility group) box	Finn RD	anon	Pfam-B_8 (release 1.0)	Domain	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  --amino -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.03	0.72	-3.71	31	8695	2012-10-02 14:16:02	2003-04-07 12:59:11	14	175	1353	52	3772	8773	263	66.20	29	17.82	CHANGED	PKRPhoAahlatp-tRtpl+p-sPshc..sspluKtlGctW+sLstc-Kt.Y.ptApct+pcaccphspYc	.......................................KRP.h..sA.ah.la....t....p...c..p.......R........p....p............l.......t........t........p.........p.........P............p............h.........p.........su.........-..............l......o.....K.hL..G....p..p...........W..+..........t..L..s.cp........-.K............p.....ah.c.c.Ap.......c...h+t..pahcphssYp...................................	0	1189	1695	2729
+2972	PF01154	HMG_CoA_synt_N	HMG_CoA_synt; 	Hydroxymethylglutaryl-coenzyme A synthase N terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.06	0.71	-4.71	4	1680	2012-10-02 12:25:54	2003-04-07 12:59:11	12	15	1444	28	478	1426	215	165.20	41	40.45	CHANGED	WPcDVGIlulElYFPoQYVDQuELEKaDsVssGKYTlGLGQs+MGFCoDREDINSLCLTVVpKLMERsslsassIGRLEVGTETIIDKSKSVKoVLMQLFpESGNTDlEGIDThNACYGGTAALFNAlNWIESSuWDGRYAlVVsGDIAIYspGsuRPTGGAGAVAMLIGPsAP	...............................................h....lGIctlthahPs.....YV.c.....hs.....-.L.....A.........c....s....R......slD....ssK.a..p...h...Gl...G...Qpchulss..sEDIlo.hussA.upsl.l.....s.c..p........-.t.p.pIshllV...uTESulDpSKu...s..us.h....l....p....pL........Lul...............p...s.......s....c.uh...E...hKpACYGuTAALphAhsalp..sp.s...........s......sc...c....sLVl..A....oD....I..........A............+.Y...........u...h..s.........s...........u.........E.P.T.....Q.....GAGAVAMLIuts..s..................................	0	147	269	383
+2973	PF00682	HMGL-like		HMGL-like	Bateman A	anon	Pfam-B_71 (release 2.1)	Family	This family contains a diverse set of enzymes.  These include various aldolases and a region of pyruvate carboxylase. 	21.90	21.90	21.90	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.11	0.70	-4.71	20	12580	2012-10-03 05:58:16	2003-04-07 12:59:11	14	57	4555	111	3825	10439	6963	236.80	26	43.97	CHANGED	RDGEQuhtss.holpcKlpIActLschGlc.IElG.............hsssuts-hctlcslsctlts...uclsslsR.............sstc-lctuhc.h.ssGsspl+lhlssS-hhhphplppsht.shcpspphlchA+phs.cV..........plusEDuuRsshsalhclsctshsA......GspplslsDTVGhhsPpphtchlptlpppls....s.lulHsHsDhGhAlANolsAlpAGAspl-solsGlG......ERAGNsuL.Eplshulcstt	...................................................................................................................................................RDGpQu........hss..h....s.....scc+lpl..........s....p..........t..........L..s..c......h.....G.....l.p......l...Esu...................hshs.u........t....s.........s.....h.....c.t..l.....p.....p......l...t.....c.....t....h..hp...............spl....p...s...L...h...p.............................................s.s...p....p.........l....c....p....s.....h....c..........h.........................s....s........h....s....h....l...........+....l.a...s...ussp...............................h.........t.........h.......s...................t...t......l...c.t...h......t....p....s.l.p..h........s......+.p...h.....s...h..ps................................ph.u...s....p......s...t....s......t....t...s......h...p.....h...h.h..c.....l..s......ct.h.h.ph...............G.s..p.h.l..slsDT.......s.......G.......h.......h.......p........P.......p.......p..............ht.......c.......l.......l.p...t.l.p..p..p..ls.........................h.lul.Hs.H....s..sh........Gh..A...........lA.s..s..l..s....A....l....c....u..G..............sc....t.....l...-..sslsGhG.......................tp..sGNssl.EsllhsLph..t.........................................................	0	1234	2475	3280
+2974	PF00423	HN		Haemagglutinin-neuraminidase	Finn RD	anon	Pfam-B_171 (release 1.0)	Family	\N	20.40	20.40	20.50	21.80	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-12.63	0.70	-6.22	21	2456	2012-10-02 00:45:24	2003-04-07 12:59:11	14	2	198	58	1	2086	0	439.80	33	94.13	CHANGED	lhshlshlLullsllhhhshplpphshsssphpphhps.hulspsIcptsccltt.....lpPhhphIsspVuhplPtplsphtp.l.......................psp............................lsctC....................shspsptshhsh.psphhpsl..shpshhhsssssh.sshs.psphp.h.ssohl..ssssshsu..Clp.PshulupslauYoaslhpssCpct......spshphhplGhlpspusthPshpsssthshspsssh+sCSlsssshthhtLCohssssphp-huoss.pslhlshLsltGphpspchpss.hshc.....sastLYsosGsGlhhssplhFhsaGsls..............pstpspupChtstCpspstphCNpu.hsshhus+hhspGllplslsh..stpsplpltolssshhhhGupu+Lh.....s.hhhYpposuWhohs.hstlsls..sshs....lphsspshs..oRPGssp..CthsspCPt.CloGlYsDsa.Lss........shphlsushlsSpps+tsPhhshssspshshhh.lp.sspspsshooosCF..sapp+laChphsElsssshsshpsh.hhspl.hsC	.................................................hhlhlhhl.lhhl..hh.hs.hhhphsh.....p...........pp..thsp.lpct..pl.........slhp.Ihcp...l.......slp.P.th.ph.p.l........................pt.......................................hs..h....................tsss..pt.hss.h....hss.....h....ltsh..ph....h.s.hp..h.sshh.........t.shl..sh.hotsh..ssp..sh.hopshYshTa.l..sshpsc......sp.hphhtlGhl+psu.shshhphhp.h..s.spshpsC.luhs.LthshLCpt.sshp....uSst.sshhhspLGh.sphpppphpssh.ht......shsthY.ustpGhhhDspshasV.sshp..............p.ppt.psC.pp..psh..thspss.h.shhss+hsp.ulLolplsh..olt...phhls.s.sslhhhGuthclh........h..ppss.sWho.s.hhshsls.h.ssh...........h.sP.hhs.......+...u..u.s..Cthssh.....lsuhhsssh.l...h......spshphVhuTh..sp.t+hssh.sh.s.hshshhh.hp.s.pshs..hp..pCF..shspchaChphh.htss..sthh.h..hsthhh................................	0	0	1	1
+2975	PF04814	HNF-1_N		Hepatocyte nuclear factor 1 (HNF-1), N terminus	Kerrison ND	anon	Pfam-B_2624 (release 7.6)	Family	This family consists of the N terminus of homeobox-containing transcription factor HNF-1.  This region contains a dimerisation sequence [1] and an  acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) [2].	28.40	28.40	29.10	28.60	27.70	28.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.29	0.71	-4.18	9	283	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	52	22	104	212	0	171.40	47	37.26	CHANGED	MsScLotLQpELLtALLpSGloKEsLlpuLs-ht......................Pthphs-p.hth..hshstutsp........th..uhGcs..................................chotDEs....S-DG--..sPPIhKELEsLusEEAAcQ+......ulV-pLLpEDPW+sAKhlKSYMQQHNIPQREVVDsTGLNQSHLSQHLNKGTPMKsQKRAALYsWYVRKQREltpQ	................................................................................Q.-LLttLhpoGhoKc.llpALtpht................................s.....st.tsh...ht.ut............................p.s......................................................+hSt-.cs...........sps.up..ca.s.....P..Pl....hp....c..h....p...s.h....s.....s.E.EAu.cpc........scV..Ec..LL..pcDsacluchIKuYhQpHNIPQREVV-sT..GLNQSHLSQH..L.NKGTPMKsQKRuALYsWYl+KQpEl........	0	17	29	54
+2976	PF04813	HNF-1A_C		Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus	Kerrison ND	anon	Pfam-B_2624 (release 7.6)	Family	This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform.  Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing.\	\	The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms [1]. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3) [2].	27.30	27.30	28.70	35.50	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.96	0.72	-3.71	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	34	0	20	47	0	81.80	65	14.36	CHANGED	llToDPEuHTDSuIcEPSS......l.sQD.osILHLQSu.RLSPsPsVSSuSLlLYpsSsSoEoH.SHL.LSSoHusI-oFISTQMASSo	......................VFTSDoEAsSESGLHsPuSQAoTlHlPSQD.suuIQHLQPuHRLS.sS..........PT..VSSSSLVLYQSSDSoNGH.SHL.LPSNHSVIETFISTQMASSS.	0	1	2	5
+2977	PF04812	HNF-1B_C		Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus	Kerrison ND	anon	Pfam-B_2624 (release 7.6)	Family	This family consists of a region found within the alpha isoform and at  the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1.  Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative  splicing.  The C-terminal region of HNF-1 is responsible for the  activation of transcription [1]. Mutations and polymorphisms in HNF-1  cause the type 3 form of maturity-onset diabetes of the young (MODY3) [2].	25.00	25.00	54.90	52.20	20.40	21.20	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.83	0.70	-5.10	11	156	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	43	2	50	130	0	219.60	56	42.10	CHANGED	AMDsapus..uss.s.hLsp.s......oPpsu...s.th..u.........................lRYSQpussEssoSos.ups.spu.....osLpQVSPsuL-PSHoLLso-sKh.IusSGGsLPPVSTLTslHSLstss....Ht.tQQsQNLIMssLPuVMuI....................s.uLsooQuQSVPVINSVGuSLTTLQPlQF.SQ......QLHsshQQPLhQQsQ.SHMu..QsPFMAThAQL.ssH.MYS.KsEssQYsHoShhsQsMVITDoosLuTLTSLouoKQ	...................................................AMDsYsus..s..s.sPhLsttSs....t.Pssu....sP...s.Khp..G.........................VRYuQ.ussEssusso.Stt...stshV.T.sposLpQVSPsuL-Pu..HsLLSs-uKh..lSsoGGsLPPVSTLTslHSLp........t.sQQsQNLIMssLsGVMAI.......................s.uLsooQAQSVPVINShuuSLssLQPVQF.SQ......QLHssaQQPLMQps..SHhu..QpPFMAshsQLQssH...hYuHK.EssQYoHouhhPpsMllTDTsslSsLsshosoKQ.............................	0	2	6	18
+2978	PF01844	HNH		HNH endonuclease	Bateman A	anon	[1]	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.73	0.72	-4.09	92	7400	2012-10-05 18:28:12	2003-04-07 12:59:11	18	79	3428	3	1824	6263	3802	47.60	26	18.89	CHANGED	Cp..hCspph...........thplcHIlPhp....p..uGpps.....hsNLhslCpp.Cppp+psc	.....................................Ct..hC..s.t..h........................thplc.Hlh.Phs...............p........GGtss....................hsN..lhhlC....tt...C.Hppcpt..................	0	538	1239	1594
+2979	PF01848	HOK_GEF		Hok/gef family	Bateman A	anon	Swiss-Prot	Family	\N	21.60	21.60	22.80	22.50	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.01	0.72	-4.63	41	1852	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	385	0	46	440	2	42.80	47	78.31	CHANGED	+thlhsLlllClTlLhFshlsRcoLCEl+l+pG.spEluAhLAh	.......KhtLlulIVlClTlLsFsLll+cSLCEl+l+pt.shEhsAhLAY..........	0	6	9	26
+2980	PF05102	Holin_BlyA	holin_BlyA; 	holin, BlyA family	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	BlyA, a small holin found in Borrelia circular plasmids that is  encoded by a prophage.  BlyA contains two largely hydrophobic  helices and a highly charged C-terminus and is membrane  associated [1].	21.10	21.10	22.00	21.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.02	0.72	-4.25	3	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	33	0	3	53	0	59.30	54	93.80	CHANGED	MDTIpIs...-FLlsLsNIKLItLhIFIollILullLllKPllKDhLoILIuKIhKNsNcKEKc	..........MDTIKlT...EhLINLNE...IKLIuVMIFlTVllL.GsLILLKPLLKDILoIl..IGKlFKNuNsNsp.................	1	2	3	3
+2981	PF05204	Hom_end		Homing endonuclease	Studholme DJ	anon	SCOP	Domain	Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life.	21.10	21.10	21.10	21.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.42	0.72	-4.11	24	211	2012-10-03 01:41:40	2003-04-07 12:59:11	9	23	116	23	55	250	50	102.50	30	13.28	CHANGED	slPpaLto-slplREsFLAGLlDS-GhVccptt.....ssolpTh.polhpGlVplARSLGlpsoVss...cptphctpsVppp.s........YslslusussLpuVLutCusscppts.........tthh	..............IPphhhppshplR.uaLAGLIDSDGhsscptt.....phslpohpsolhcsllplARSL.Glssssss...c.th.h.hptsph............Ysh.h...t.t...t...s....h.t.s...............s.hhh..................................	1	5	22	47
+2982	PF05203	Hom_end_hint		Hom_end-associated Hint	Studholme, DJ	anon	SCOP b.86.1.2	Domain	Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce [1] revealed two domains: an endonucleolytic centre resembling the C-terminal domain of Drosophila melanogaster Hedgehog protein, and a  a second domain containing the protein-splicing active site. This Domain corresponds to the latter protein-splicing domain.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null --hand HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.37	0.70	-4.60	37	308	2012-10-03 10:25:13	2003-04-07 12:59:11	11	40	197	12	58	405	104	284.60	23	42.25	CHANGED	CauKGTpVlMuDGopKslEclplG-tVMGpDGpPR..cVhsl.s+Gp-pMYclppps.p..................shhsasCsusHhLVL+ss.th....p..th.....................t.R....lsp.hptsa..p...u..tt.thhpph.ts.sscphhpaslpA+Dhs.tLssplRpso...pthhsPlhhtpt.hsphltstt....p.s...s..huYlLGLWlGsG.htcpsphshsopD.tplh..pplpphup..hhslp.phtptp.shh.t..........................................................................h......t..ht..............................................................................................................................................tshspsN.hhptlh.phGhhp........phsKpl..Pphhhs-shphREtFLAGLlDocGhl..pt......psslpsh.pplhpslltlARSLGlpsslspcptp...hthtt..............athp.lssssshhssLshsttspp.htstspth.ct...htFphhE.hpps-aYGlTl..-sD+paLLushhVlHN	........................................................................................ChstGT.lhhuDGs..cslcslphG-hlhG.D.....G....p.....s+......cV....hsl....s....p...Gh-..p..hY..plp.ts...........................................................th.shsssssH.Lshh..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	13	33	53
+2983	PF00046	Homeobox	homeobox; 	Homeobox domain	Eddy SR	anon	Unknown	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.63	0.72	-4.35	182	25115	2012-10-04 14:01:12	2003-04-07 12:59:11	24	290	1497	161	11025	24665	26	54.40	35	16.80	CHANGED	++pRTsaospQlptLEptFp...p..spYsstpcRpcLAppL.....sLs-ppVplWFQNRRtKhK+	........................................++.Rs.s.a..o.p.t.Q......l..t..t.L.E...c...tFp.................p...s...pY.......st....t..c...........R.t.clA.ppl........................sLo.c.....p..p..V...........p.........l......W...........F..Q.N.RRhK.++......................	1	2391	3737	7103
+2984	PF00742	Homoserine_dh		Homoserine dehydrogenase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_459 (release 2.1)	Domain	\N	22.90	22.90	22.90	23.30	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.90	0.71	-4.60	147	5558	2009-01-15 18:05:59	2003-04-07 12:59:11	14	32	4234	19	1325	3990	2377	185.10	37	33.91	CHANGED	Pllcslcps.LsGsclpplpGIlNGTsNaILopMp....p..GhsFpcsLc-AQchGaAEs.DPstDlsGhDsApKlsILAphshGhpl..s.hs-lthcGIsslsht.......................clphA.pchGhsl+Ll..................uts..ch............ttth.pspVpPphlspscsLAp.lpGs.Nulhlps-hh......uslhlhG.GAGstsTAuuVluDll	.............................................................PllcsLpph..huuDcI.....ppltG.IlNGTsNaIhschs..................pt...GhsFs-slppApp...hGauEs.DPpsDl....sGhDsA+Kl....sILAph..........h..G..h........p.l.......p....hs.-l..t..l.E..G.ltslshp................................clp.hA.cc.h...G..h.sl+hl........................uhhc........................tshpscVpsshlsps.+PLAs.Vpss.NA..........lhlpuchh......ssl.hh.....hG.GAGstsTAuuVhuDll..................................	1	417	834	1118
+2985	PF00103	Hormone_1	hormone; 	Somatotropin hormone family	Sonnhammer ELL	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.21	0.70	-4.99	17	1608	2012-10-02 01:28:15	2003-04-07 12:59:11	15	2	560	24	164	1561	2	156.40	32	94.64	CHANGED	LlhSshLLsp.....suSsPsss..........LpcLFppAsphucphapLusphas-F-ppahptpt.......hhpts.......shCHTsolpsPps+-pspphstpcLL+hslhLL.SWppPLhhLss-hpsh.ts..stsllo+Ap-lpcp.cpL.pslcplhp+l...stpphp.h..tasphu...tscc-p+hhshYsLhhCh++Ds+Kl-hal+lLpCRhhhp....C	.............................................................................................................tpLhs.sh.hsphla.Lu.tchhp-F.....-c..p..hhsppp...................h.p.............shChopol.s.PpsK.ccs.Qp.h.o......hc.LLchuhhLlpS.W.tPlphLs....t......ts..s......h.t..p...cl..tht.L.......cuh..h...th.....................................h.h..ths.............pptlht.at..Llt..Ch++D.cKh-saLplhpCR.......C.......................................	0	6	15	61
+2986	PF00123	Hormone_2	hormone2; 	Peptide hormone	Sonnhammer ELL	anon	Prosite	Family	This family contains glucagon, GIP, secretin and VIP.	21.20	21.20	22.50	21.20	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.58	0.72	-6.64	0.72	-4.09	56	842	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	138	23	275	773	0	27.80	39	34.80	CHANGED	HuDGoFTs-ho+hL-phuA+cFlphLhs	.......HuDGhFTssYS+hLcphus+calphLl.....	0	10	29	91
+2987	PF00159	Hormone_3	hormone3; 	Pancreatic hormone peptide	Sonnhammer ELL	anon	Prosite	Family	\N	22.40	22.40	23.10	22.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.54	0.72	-3.94	21	274	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	120	32	90	268	0	35.70	61	41.61	CHANGED	hPscPc..tPG-sAssE-..LupYhssLpcYlNllTRpRY	.........YPsKP-..sP.G-DAssE-..hA+YYuuLRHYINLlTRQRY.	0	8	14	32
+2988	PF00220	Hormone_4	hormone4; 	Neurohypophysial hormones, N-terminal Domain	Finn RD	anon	Prosite	Family	C-terminal is in hormone5	17.00	17.00	17.00	17.10	16.90	16.90	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.55	0.74	-5.72	0.74	-3.80	8	197	2009-09-11 03:36:00	2003-04-07 12:59:11	12	2	104	0	51	205	0	9.00	83	7.31	CHANGED	CYIpNCPhG	CYIQNCPhG.	0	3	5	25
+2989	PF00184	Hormone_5	hormone5; 	Neurohypophysial hormones, C-terminal Domain	Finn RD	anon	Prosite	Family	N-terminal Domain is in hormone5	25.00	25.00	25.00	31.40	21.80	24.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.37	0.72	-10.76	0.72	-3.44	36	207	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	109	29	60	232	0	77.00	63	55.90	CHANGED	RpChsCGPGs+G+.....CFGPsICCG-pl......GCalGTsEoh+CtEENYL..soPCps.GG+sCGs.t....uG+CAAsGlCCssEoCshDssC	........RpChPCGPGs+GR.....CFGPsICCG-pL......GCalGTsE..shRCpEENYL..PSPCpu.......Gt+sCGS.............GGRCAA...sGlCCss.-.uCshDssC................	0	6	8	30
+2990	PF00236	Hormone_6	hormone6; 	Glycoprotein hormone	Finn RD	anon	Prosite	Domain	\N	25.00	25.00	25.60	25.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.49	0.72	-4.17	10	201	2012-10-02 16:54:34	2003-04-07 12:59:11	13	2	150	10	30	185	0	91.40	69	81.48	CHANGED	aPcs-hss.GCsEC+L+ENphFS+.GAP.IYQChGCCFSRAYPTPLRSKKTMLVPKNITSEATCCVAKphhRVTVhsslKlENHT-CHCSTCYYHKS	...................aPss-h....GC.EC+L+ENphFS+...GuP...lYQCMGCCFSRAYPTPlRSKKTMLVPKNITSEATCCVAKphp..+...spV..h...s.....l+.lcNHT.......-CHCSTCYYHKs.................	0	1	3	11
+2991	PF04617	Hox9_act		Hox9 activation region    	Kerrison ND	anon	DOMO:DM04544;	Family	This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].	20.60	20.60	25.40	22.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.56	0.71	-4.11	29	299	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	74	0	96	259	0	167.00	38	65.14	CHANGED	MSoSGTloNYYVDSlIspEs..EDhh.usRF.ssushssss.......R.su.s.s-pu.....-asSCoFtsKssVFuuS.WSsl..ps.pssss.sulYH.....PYh.....t.Qstl..suuDu...RY..lRSW.L-Phsssl.shsGh..ssspp.Y...ulKPEsl.u+ts.-s.shcspshhh...s-atssusssspcp...tppttstspssspsp......pE-K....pplDP	..................MSsoGsloNYYVDSllsHEs..E-lh.u.......uRF.ssGs.h.stss.......R.su..l..s-.ps......-FsSCSFtPK..ssVFuu.S.WusV..ps.pssss.s.uVYH........PYs.......p.Qs.l....susD.u.RY..hRSW..LEPhsusl....uhs..............Gh...s......su.....+p.Y...u...lKP-......sh...upps.-s......ts.ps.sh.....s-Yhhsssss.cpp....st.ts....scs.stsct.....pc-K...thD....................................................................................................	0	4	13	43
+2992	PF01856	HP_OMP		Helicobacter outer membrane protein	Bateman A	anon	Pfam-B_395 (release 4.2)	Family	This family seems confined to Helicobacter. It is predicted to be an outer membrane protein based on its pattern of alternating hydrophobic amino acids similar to porins [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.15	0.71	-4.41	33	2354	2012-10-03 17:14:36	2003-04-07 12:59:11	12	2	57	0	129	2284	1	164.40	30	37.09	CHANGED	ulplGYKpFFs..p....p+hhGhRYYGFaDYsauthspppht.s...............................shhTYGsGsDlLaN..h.hspppt.......................................shGhFuGlplAGsoWhsstt.thth..............................................psphpsotF........QhLhshGlRhshs...............t+pulElGlKl.Phltppah........................sshshps..pa+R.auhYlsYsasF	.........................................hplGYcpFFs.........p...........p..+..hhGhRYYG.Fa-Y..s.......auhht...pp.th..t...............................................................................shhoYGs.GhDh..LhN.....h..hssp.pt..................................................shG..lFuG....ltluGs....o.ahssptsphts..........................................................................t.phpsstF........QhhhshGlRhpht...........................tcpshElGlKI.Phl.pp.phh......................................sshsh.ph...p.a.cRhashYhsYsasF..................................................................................	0	39	93	129
+2993	PF02521	HP_OMP_2		Putative outer membrane protein	Bashton M, Bateman A	anon	Pfam-B_1230 (release 5.4)	Domain	This family consists of putative outer membrane proteins from  Helicobacter pylori (campylobacter pylori). 	25.00	25.00	29.60	28.90	20.30	16.40	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.48	0.70	-5.91	9	419	2012-10-03 17:14:36	2003-04-07 12:59:11	9	1	55	0	36	429	0	455.30	38	98.14	CHANGED	hppphhhhlhhhhhsusLpAF-Y....+lsGts-SFSKlGFNpppINsp+GIYPTpoFsTlsutLpls.ssLLsKthpt..HsLcsslGGhlGulsYDSTKh..........................h.sp.........st.hhsulsa.alGhatGahssp......................s.hst..p.st............+sRsYll.NAaLcYsYKD...hFthKuGRY....puph.-ahSGasQGaEhhh.....phpph+hhWFSSaGRAhAaspWlh-aYus+s.h.pst..hN.............hGhHshslhYp.hKslplpPFhYasPthhsAPGhpIsaDoNPsFpuhGFRupTshhsha.............Plas..h....hsshp......hss.hGcsGtoLhl+QRF-aNpaNFGhuhYpsFGNANuhIGhaGNP.....................lGh-hWsNolYss...ulsshhsAsAhThasasGGsa..+pFhWplhGRhTpus........RAsEtSlulsLuYphsc.plpssl+LpYYsshh+pGYp.hGhhh.....sPh...................ssshpuhhpDRSalMoslsapF	...................................................................h.....hhhh.hhhh.t.u....LpAF-a.......clsGtspsFSKlGFNpp.....INspKGIYPTpoFsolsuhlpls.ssLLsKth.ps...HtLpsslGGhlGulsYDoTKh...................................................hhsp...........s...ht.u.hhapahGhatGahsst.............................................s.tss...p.phst............psRsYllhsAaLp.YsYKD.........hFthKuGRY....posh..sahSGasQGF-hhh..........php.ch+hhWFSSa.GRuhAhs.pWlhsa.Yushs..h...pt...t..hN.............aGhHshslhYp..pK......tlplpPFhYFuPpsatAPGhpIsaDoN.PsFp.uhGaRspTphhsha....................................Plahshh..........hsshh...............hsshhGpsGtoLhl+QRFc.a.NpapauhuhYpsaGNANu.lGhaGsP.....................hGh-hasNolYss...shsshhsAsuhThashsGGha.......++FhWtlhuRhTtus........RAsEtululsLuYphs+.plphsl+LpYYsshh+pGYp...sGhh..........sPh...................tsshtushpDRSalMoslshpF.......................................................................................................................................	0	9	26	36
+2994	PF03328	HpcH_HpaI		HpcH/HpaI aldolase/citrate lyase family	Mifsud W, Bateman A	anon	Pfam-B_3076 (release 6.5) & Pfam-B_2811 (release 14.0)	Family	This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.16	0.70	-5.46	22	6388	2012-10-10 15:06:27	2003-04-07 12:59:11	9	23	2567	40	1697	6456	3815	211.30	23	76.53	CHANGED	phhhalsusssthhchsshhGhDhlhlDlEcus...........hhltpsLpplph.tss...pslVRVssh-oshhpp......hlchGspslhlPhV-oup-stph.phhphs.tthtt.........................tsspsplhstIESupGlhNscEIA..usc........tltulhlGstDhssshGttpssstsElh.....hApsplltAu+AuGl.hhsslhsshssspsahpputhhhslGhDs+.hhps	.........................................................................................................................................................................................p.hhahsh.sss.h.hh...ph.h...t...h..h...u......h...D...hl...ll.DhE.c.us...................................................p..tl...t....p....h.l..p.......p.h...........t......h...........t....s......h.......................ps..l..VR.l.s..s..h......s...s.......h......h.....t.....p..................................hl....c...h.............G.....s....p...........s....l......h...lPt...l..co...s...pc.s...pph....st....th.p..h..................t..th..................................................................................................................................................s...tp..h.t.l...l..s.......I.E.o.s...p...G...l.......t......s.........h...s...p....IA.....us..p......................t.ls...ul...h...lG...s....s...Dh.....s..........t..........s.........h.....G......h....t.....t........s.....s.....p....t...s..-..l.....................................hAh....pp....l....h....t.A...u....+.A..s......G......l.....s..h...s..h.l..h.........s...........s.............p...s.......t...p.......t........h...h...p...t.u.t.p...h.h.t..lGhc.st.hhp.........................................................................................	1	422	997	1374
+2995	PF04982	HPP		HPP family	Bateman A	anon	Bateman A	Family	These proteins are integral membrane proteins with four transmembrane spanning helices. The most conserved region of the alignment is a motif HPP. The function of these proteins is uncertain but they may be transporters.	21.10	21.10	21.10	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.55	0.71	-4.27	127	972	2012-10-02 19:04:43	2003-04-07 12:59:11	8	10	814	0	435	951	937	121.40	34	44.35	CHANGED	hllAshGASAVLlFusPsSPLAQPhslluGplloAllG....ls...shphh.............ss.sh..........hus...uLAVulAIshMhhs+slHPPuGAsALlslluus.......GatallhPV.hluullLlhlAllhNs.ls..t.R.pY..Pt	..........................hllAshGASAV.LlF.u.sss.S.P..LA.QPhs..llsGplluAllG....ls...shphh....................ss..sh...........hss....ulAluhuIshMhhh+slHPPuGAsALls..l..luss..................uat.a.l.l.h.PV..hluu.llllshA.llhss.l....t...+..pYP.................................	0	128	267	361
+2996	PF01288	HPPK		7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.50	21.50	22.70	22.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.69	0.71	-4.40	115	4673	2009-01-15 18:05:59	2003-04-07 12:59:11	15	34	4045	60	1118	3316	2284	125.90	37	60.63	CHANGED	aluLGSN....l.GcptpplppAlptLpph.thplhphSslYcotPh.G....hssQs..t.FlNsVlplcT.sLsPtpL.LphlppIE.pch.GRtR.pt....+a..u......PRslDlDlLha...ssh..............h...l.....ps.......s.p............LplPHPchtcRsFVLhPLs-l	......................................................aluLGSN...........lus.....h...pplppAlp..........tL.......s.p.............h....................t...........h.p.....l.....lthSslYcTtPh...G................hp.s.Qs......s.....FlNss..l..t..l.........c.........T.......s..........L.......s....Pt.p.......L.Lp.t.....hppIE.pp.h.GR.....hR...pt.......+W...G.................PR.T.LDLDIlha.....ssp.......................h.....l.........ps....................s.c............................................LplPHs.c.hppRsFVLhPLh-l............................................	0	368	712	952
+2997	PF02603	Hpr_kinase_N	Hpr_kinase; 	HPr Serine kinase N terminus	Bashton M, Bateman A, Moxon SJ	anon	COGs	Family	This family represents the N-terminal region of Hpr Serine/threonine kinase PtsK.  This kinase is the sensor in a multicomponent phospho-relay system in control of carbon catabolic repression in bacteria [1].  This kinase in unusual in that it recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating enzymes [1]. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller. The blades are formed by two N-terminal domains each, and the compact central hub assembles the C-terminal kinase domains [2].	24.00	24.00	24.00	24.00	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.16	0.71	-4.45	84	1842	2012-10-03 03:17:47	2003-04-07 12:59:11	11	6	1787	8	328	1032	93	127.40	32	40.73	CHANGED	tp......lplpcLlcc....h..pLclls..Gccslppp.IssuDIsRPGLpLsGaFsaassc...RlQl.lGpsEhoalp.phspc.p+tphhcchhs.hcsPslIlo+sL..psPp-llcsAcctslPlLpoph.sToclhuplopaLc	........................................tlplccLl-p.......l..pL-.lls...Gc.c.s.lpct..Is..s.u..Dl..s..R..P..G..LEhsGYFsaass-...RlQl.lGpsEhoahp......p.hssc..pRh...phhcchhp..-sPslIloRuL............psPcEllcu.Acc...pslPlLpoph..sTop.LhucLosYLc............	0	115	218	275
+2998	PF01627	Hpt		Hpt domain	Bateman A	anon	Pfam-B_971 (release 4.1)	Family	The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined [1]. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to  contain a binding surface for Ssk1p (response regulator receiver domain containing protein Pfam:PF00072) [2].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.91	0.72	-3.98	241	11727	2009-01-15 18:05:59	2003-04-07 12:59:11	18	665	2711	46	3296	9899	750	93.10	19	13.09	CHANGED	pllphFhpc.stchlpplppsl...p...............ttshpplhctsHpLKGuuuhhG.hpplsphspplEphhcptp..ptp.............h.thhptlpphlpplpst	............................................................................hlphFhpp..st.ch....l.ppl.pp.tl....p...........................tpshp..s.lhctsHplKGu.uu.hl.......G.hp.p.ltpls....ppl.E..p.h.h...pptp...psp..............................t.l.pthstlpp.lt.....t.....................................................................	0	1088	2075	2778
+2999	PF01628	HrcA		HrcA protein C terminal domain	Bateman A	anon	Pfam-B_1133 (release 4.1)	Family	HrcA is found to negatively regulate the transcription of heat shock genes [1,2]. HrcA contains an amino terminal helix-turn-helix domain, however this corresponds to the carboxy terminal domain.	19.90	19.90	20.00	19.90	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.04	0.70	-4.77	165	2791	2009-09-11 06:48:32	2003-04-07 12:59:11	16	9	2743	3	636	1950	812	218.70	24	63.95	CHANGED	l-cllppuuclLSpLTphsullhsPp.hppspl+plclVsls.sp.plLsllVscsGpVcspllpls.....................p..sl.sssc....LpphsshlNspLt......Ghslsclppplhp.t.lttthpp..htphhcphlpthtps.h..ttt.......tp..pclhlsGpsNllpts..Ea.ps..........hpcl+pllphl...Epppt..lhpLl..........tps.p.psp...s.....................lplpIGsEs..........hpshpssSllousYphs..s.....p...........................sl.GslullGPTRMsYs.+sl	..........................h-cllppuuplLSplTphsu.l.lhsPp...p.psplcplcll.Ls..sp...pslslllsssGpVcsphlpls....................p.sh..sppp....Lpch.sshlNp+lt......Ghs..l..t..-lpp.pltp...p....l...........s.p.h.h.pp..................ht..p..hhps.llshh...tph.h.t......p.........pplhluGpsNLlphs...ph..ps..........hp.plpplhphl...Ep.ppt..lhpLl...........pph..t...psp.......s............................lpltIGsEs........t...tsl..p..shS.llousYths...t...p.........................................................................hh.GslullGP.T.R.MsYsphl.......................................................................	0	229	443	550
+3000	PF04877	Hairpins	HrpZ;	HrpZ	Kerrison ND	anon	Pfam-B_6141 (release 7.6)	Family	HrpZ from the plant pathogen Pseudomonas syringae binds to lipid bilayers and forms a cation-conducting pore in vivo.  This pore-forming activity may allow nutrient release or delivery of virulence factors during bacterial colonisation of host plants [1]. The family of hairpinN proteins, Harpin, has been merged into this family. HrpN is a virulence determinant which elicits lesion formation in Arabidopsis and tobacco and triggers systemic resistance in Arabidopsis [2].	20.50	20.50	31.60	20.50	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.01	0.70	-5.01	11	233	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	84	0	19	217	1	221.70	27	93.65	CHANGED	MQh.............L...uhssu.LtoshtshsLstsps.s.u.uoSocpLppVIsQLAptLT...................tsGphssoSPLG.....................................KhLsKuhusD........................................................GctGGhhcsVpsALcpLIpEKLGDNFGAuus..............ss.GhtGh.tsuuuuuQpDLhspVLsGLuK....usLsDLLT.ppusGToF.ScDDMPMLccIAQFMDDsPupFspP............DuGSWupEL.K.EDNhLsGsETAQFRuALDlIGptLupptsttssh.....sGGLG.................................G....DsGp.h.....hGhpu..uGtGhGoss.s..p............phspLltGL..pGLtusLpssGtsGssLpsSAApsushllshhL...pNpusA	.............................................................................................................................................................................................................................................................................................s..ss..psl.ssLptlhtptLup..ut.s....................................susss..pLhstl..h.ulup....p.Lssl.s.p.....p....sss.ppF.s.....ppDhshhpclupFMDp.Pt.FspP............DstS.....WhptL.c.-Dsh.....hs.tphttFppAh.shItpthu......................................................................................................................................................................................st......................................	0	0	5	11
+3001	PF02218	HS1_rep		Repeat in HS1/Cortactin	Bateman A	anon	Pfam-B_5631 (Release 5.2)	Repeat	The function of this repeat is unknown. Seven copies are found in cortactin Swiss:Q14247 and four copies are found in HS1 Swiss:P14317. The repeats are always found amino terminal to an SH3 domain Pfam:PF00018.	21.00	21.00	21.50	22.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.57	0.72	-4.07	18	1059	2009-01-15 18:05:59	2003-04-07 12:59:11	10	23	81	0	511	857	0	34.90	59	36.89	CHANGED	GFGGKFGVQpDRhDKSAVGaDYpuKl-KHsSQ+DYu+	.........GFGGKaGVQpDRhDKS...Al.Ga-YptchpKHpS.Qp...Dhs.................	0	125	164	293
+3002	PF00447	HSF_DNA-bind		HSF-type DNA-binding	Finn RD	anon	Prosite	Family	\N	21.00	21.00	21.00	21.00	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.76	0.72	-3.86	114	1989	2012-10-04 14:01:12	2003-04-07 12:59:11	12	26	337	17	1305	1973	19	99.60	36	21.34	CHANGED	sFlpKlaphl-..........Ds............shsplIpWs..ps.G...soFllhs.spcFupplL..Pp...aFKHsNauSF........VRQLNhYGF+Klpsspt......................................................aEFpppt..F.p+Gpc.........cLLpp..I+R+pssp	........................................................FlpKh..a..p.hlp............................-s.....................p.h...s..pll.pWs...ps..G.............soFl...V.hc........p.pF.sc..........p...l.L.........P.c.............a.F......K............H......s....N....auSF...................lR.......QLNh....Y....G.F+Klstsptt.........................................................hEFtp.t...F.h+G.p...........pLLpp..I+R+t..s........................................................................................................	1	519	792	1058
+3003	PF00011	HSP20		Hsp20/alpha crystallin family	Sonnhammer ELL	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.33	0.72	-4.16	37	9881	2012-10-02 21:54:05	2003-04-07 12:59:11	16	34	4016	178	3585	8031	3065	97.10	23	59.55	CHANGED	-h+cscstathphDlsGhp.t-.-lcVplc-sp..lllpupcc......Eccsschhh.tht.tpFhR+apLP-..ss-h-plpush.psGVLslolPKhtst.......ps+sIplp	..........................................................................................pscspat.l.p.h-l..s...G..h...p..p...........-..-.lc..l..p...l.....p..s......s..h........Ls....l..p...up+p..............................................tp.p...p..p......p...p...h..h..h..p...t...h..............t..p..F.p.....Rp..a.p.L.....s.t.................s.....s.....-..t...p..p..l.p.Ash...ps...G..l.Lplsl..s+ttsp........psppItl............................................	0	1108	2207	2972
+3004	PF01430	HSP33		Hsp33 protein	Bateman A	anon	[1]	Family	Hsp33 is a molecular chaperone, distinguished from all other known chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localised protein with highly reactive cysteines that respond quickly to changes in the redox environment. Oxidising conditions like H2O2 cause disulfide bonds to form in Hsp33, a process that leads to the activation of its chaperone function [1].	21.40	21.40	22.00	21.90	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.46	0.70	-5.28	181	3184	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	3110	8	630	2039	673	275.00	33	92.77	CHANGED	pDtlh+.hhhpsts.....lRuhhlphs.pshpcshpp.Hs.......hsssssthLGcslsussLlu.usLK..hc.splolplps...sGPlshlls-s......sssuplRGhs.......t.spsph.s............sltthl...Gp..GhLsl.oh.D......uh....tp.YpGhVsL...tus......plu-slptYatpSEQlPotlhLush....t.........httAuGhllQhLPss.............................cc.-shsclpphhp.....shhsptLl..shsscpl.Lp+La..p-t........lclh-s....pslpFpCsCS..+ERhts.sLtslupcElpchlpEp.Gpl-lsCcFCsppYpF..st	....................................................................................................................Dhlh+hlhpsts.....lRuhhlpso.colppshp.p.Hs..............hs..sss..pssLGchLsAssLLu.As.LK...hc.sclTlp.lpG..........sGPlshllssu.........s.sptplRGhs........splsh...s.t.................sltshl......Gs...Ghl.sl....sh..D..........u........t-.YpGhVsL..us.........plu-slphYatpSEQlPoplhLssh......pps.........................htsAGGhllQlhPus.............................pc-shs+lpphhp........shho.p..Ll.......shs..s-pl.LhcLat..--p....................lpl.h-t.......................pslpFp..CsCS....+E....Rhts.ALh.oL.scc...Elpshl...pE.....-.tt..h-hpCcFCsscYpFs.....................................................................................................................................................................	0	197	392	522
+3005	PF00012	HSP70		Hsp70 protein	Bateman A, Sonnhammer ELL	anon	Prosite	Family	Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release.  Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	602	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.87	0.70	-6.61	33	23002	2012-10-02 23:34:14	2003-04-07 12:59:11	15	120	7604	156	6301	21235	9750	370.00	30	85.27	CHANGED	llGIDLGTTNSCVAVh-uGcsclIsNsEGsRTTPSlVAFscs.ERLVGpsAKpQAlsNPcNTlausKRlIGRcas-..lpp-hp.hPa+lsps.sscshlpsp...Gc..paoPpcISAhlLpKhK-s.AEuYLGcs..VscAVITVPAYFNDuQRQATKDAGpIAGLpVLRIINEPTAAALAYGLDKps.......-cpIlVaDLGGGTFDVSlL-ls..cG..VFEVhuTsGDTHLGG-DFDp+llcallpEFK+c.pGl.DLppDphALQRL+-AAEKAKh-LSS.tpTplsLPalohsstG..shclshsloRA+FEcLssDLlcRThpPscpAL+DAtls.ts-ID-VlLVGGSTRlPtVQchVcchFG.K-PsKuVNPDEAVAhGAAlQuGVLoG......-V+DlLLLDVoPLSLGIEThGGV.hT+LIpRNTTIPTKKS.QlFSTAsDNQs.uVpIpVaQGERphspDN....+hLGpFcLsGIPPAPRG.lPQIEV..TFDIDANGIlsVoAcDK.uTGKcppIoIpssuG.Loc-EI-+..................................MVc-AEpaApcDcpp+EplEs+NpuEshsass-pplc-h.....t-KlssscK....pplcsslptLcpsh....ttt-......h-chcschccLpphs.tlspphYp	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.l........s....h..l....h......t.t............s......p...t.................h............t......t...................l.........t...............t.........s..........V.........l.........sh.P.......s.............a........s.......s........t.......p.......+.....p....t........h......h.......p.........A.......u.......t.....h.......u..........G.........h............p......s....................p.........l........l........p...E.....P....s.........A..A............u...h...........s.....a......t....hp...p.t................................t.t...l...h..l..hDh.................G..G...G...Th.D.....h...o.....l...l...........p.....h...............t...............t.......s........................h.......p.........l....h......s.......s.....s.........t...s......t.....................l..G.......G.............p..........s.h....D..................h...h.....h.p..............h.h....h......t........t...........h............................................................................................................t..............................................p...........................................t......p..........l....h......p.............t..s......c.....t...s...K..............h..................t...........L.....S....s..............................t........................t......h.....................h..................................h.............................................................................................................................h.......................t.................l...s..............c..............t..........p................h............p.....t...h.......................................h.....................h...............t.....t..............................h.............h.......p............s.......l......t.....p..........u............t...h.....p...............t..............t.........l..................t.......t...l....hh.s.GG...s.phPh....l....p..l..t.......t........h.................t.......................................................t.......................p....s.............t....s...h..s...G...s..s........h...............s.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	2234	3809	5213
+3006	PF00183	HSP90		Hsp90 protein	Finn RD	anon	Prosite	Family	\N	24.40	24.40	24.50	24.50	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	531	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.95	0.70	-6.11	11	5703	2009-01-15 18:05:59	2003-04-07 12:59:11	13	30	3641	350	1566	4977	1328	358.50	32	66.61	CHANGED	EYLEEc+lKElVKKHSEFIuYPIpLhVpKEhEKEVs--Et-ppc-Etc-c-..............t.chEEs--EcEc-pKK.KTKKVKEsspEhE.LNKpKPIWpRsPc-lTpEEYuuFYKSLoNDWED...LAVKHFSVEGQLEF+AlLFVP+RAPFDLFEsp..KKKNNIKLYVRRVFIhD-s--LIPEaLuFlKGVVDSEDLPLNlSREhLQQNKILKVIRKNLVKKsLEhFpElA......................EcKEsacKFYcpFSKNlKLGIHEDusNRs+LAcLLRapSo+SsD-hsSLcDYVoRMK-pQKsIYYITGESKcpVEsSPFLEpL+cKsaEVlahTDPlDEYshQQLKEFEGKKLsslTKEGLcL-EsE-EKcpcEchKccaEsLsKhhKc.lLsDKVEKVVVSsRLssSPCslVTSpaGWSANMERIMKAQALR...DoShsuYMuuKKshEINP+HPIIcEL+c+.scsDpsDKoVKDLshLLaETALLoSGFsL--PpsaAsRIaRhl+LGLsIDED-ps..p-..spsthpstssscpssssScMEEVD	...........................................................................................................................................................................................................................................................................................................................p.......c......p.............lNptpsl......Wt.Rs.p-..lopE..-Y.tpFY.................+p.l.s.p..-..a.....p-........L.h.hh.H..p..sE...G..p..hcapulLalPp.p.s.P.a..D..h...a.p...p............t..p..p.s....lK.L...Y..V......p.....RV.FIhDs.s..c.p.hhPpa.LpFl+.GllDSpDLPLNlSREhL.Q.......p......s......p......hl.c......hl+ps....ls.K..+s.l.p.hh...p...c.l..s..............................................................................c..c.t..-.p.....Y.p..pFa.ppFuh...........slK...G..h...h...p....D........t.....s.....+...p.....p.ltc.LLp..at.......o.................o.................p.................p..............t.......t..........p..................h..............s..........o........Lp..-.......Y..l...................p..R.....................M...........p..........................-............s..Q.....p......p............IY..Y.l.s..........u..p.sh......tt...............h.ppSPalEhh+p+..G..hE..Vlhhs-...l.D.Eahh.p...l...p..-.a.........-...........s....K.......t.....h...s......l.......s........c........t....t.......h....p......l.......t......p........t.......-........c.......p.....p......p........t...................c.......p......................p..........t...........t............h...........p..........s.l.h....p.h.h...Kp....h...L..t..c...c.........V.p...c....V........h..l........o...p.R..L.........s..s.....o...P..shl.s.s..s..t....t..h.sh.p.Mt+.hht..t...............................................h................p.....hhElNsp...Hsl..l.p.t...........h...............................................................t.......t..........t............h...........t...p......h....s..l....lhp.u.hl...p.t.............t..p.s..t.....a.tth.p.h................................................................................................................................................................................................................................................................................................................................	0	594	973	1277
+3007	PF04119	HSP9_HSP12		Heat shock protein 9/12	Wood V, Finn RD	anon	Pfam-B_14318 (release 7.3);	Family	These heat shock proteins (Hsp9 and Hsp12) are strongly expressed, an increase of 100 fold, upon entry into stationary phase in yeast [1,2].	26.30	26.30	26.30	26.70	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.95	0.72	-3.89	24	130	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	97	2	87	129	0	58.00	47	59.56	CHANGED	MSDsGRKsh..............o-KspEtlTPDSpKSThEKsKEsVTstsD+hAussps-spKShsQpssDp	....MSDsGRKsF..............osKApEplpPDSpKSshE+sKEplTDssD+lAushQP-spKSssQpstDp.......	0	23	49	74
+3008	PF04213	HtaA	Htaa; 	Htaa	Yeats C	anon	Yeats C	Family	This domain is found in HtaA, a secreted protein implicated in iron acquisition and transport [1].	21.80	21.80	21.80	21.80	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.04	0.71	-4.01	25	599	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	181	0	91	421	21	153.20	31	45.43	CHANGED	sslssGshs..WGlKpSFpsYlpGs.lApGsaphss...Gus...tssspFsF.shssushD...ssspssslpasGsV+as..GHp.............hhLDlslussclshsGssGpLhs-lsSpphp.sstsshut......lslAslshsuhsh...ssssshss.ssstLTtpGupsFusaYsAGpsLDPlohshsh	...................................t..ltpGohsWGl+pSFpsYlpus......s.....pG.p..hphsu................Gus........hssstFsF..shs...su.sh..D....ssps.sslpasG.s.V+as.Ghp....................shLDlolu-Ppls.lp..s.u..s..uplhhs.lp..Sps.hs...u.p.hshuc..................lshushssusht........ssssshsu.ssspLTupGscs.F..u....G.....FY..psG.p..s..h..Dslohslt.h.............................................	0	28	66	91
+3009	PF00126	HTH_1		Bacterial regulatory helix-turn-helix protein, lysR family	Sonnhammer ELL	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.67	0.72	-4.23	1536	86700	2012-10-04 14:01:12	2003-04-07 12:59:11	22	49	4604	63	20714	62728	5685	59.70	33	19.98	CHANGED	lppLchFhslscps.ShopAAc.pLsl...opsulSpplppLEp.pLGsp....Lhp..R....tt...p...t..l.pLTttGp	........................ppLchFhs.l.sc.pt....ohopA...A..c...pL..tl..........op.s...ulSpplpp.L....Ep....pL....G.s..p........Lhp......R...............ss...+....p......l.pLTptGp........................	0	3926	9597	15357
+3010	PF04967	HTH_10		HTH DNA binding domain	Bateman A	anon	COG3413	Domain	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.14	0.72	-4.38	30	808	2012-10-04 14:01:12	2003-04-07 12:59:11	7	73	81	0	433	919	135	52.70	37	16.19	CHANGED	LT-+phplLptAachGYF-hPRcsslp-LAcplGIScsohpp+LR+AppKlhp	................LTc+QpcsLptAhctGYa-hP.Rc.sohp-lAcpLslSpsohsp+LR+App+ll.t.......	0	47	296	420
+3011	PF01022	HTH_5	HTH_ArsR_family;	Bacterial regulatory protein, arsR family	Bateman A	anon	Pfam-B_139 (release 3.0)	Domain	Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-7.91	0.72	-4.29	42	9132	2012-10-04 14:01:12	2003-04-07 12:59:11	15	65	3608	33	2609	16970	1782	47.00	32	34.44	CHANGED	cssRlcIlhhLtc...sp.hsls-lsptlphopuslScHLchLcctGlVpp	..........................................c.sRlp.I.l.t.hLtp.........s-...h...s....V.......s.......-.....L.....s......p......t......l......s......h......o.....p.....s..s.l.SpH.Lph.L.+psuLlp...............	0	903	1744	2237
+3012	PF01418	HTH_6		Helix-turn-helix domain, rpiR family	Bateman A	anon	Pfam-B_3373 (release 2.1)	Domain	This domain contains a helix-turn-helix motif [1]. The best characterised member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.14	0.72	-4.25	10	9722	2012-10-04 14:01:12	2003-04-07 12:59:11	12	9	2886	5	1519	5638	383	75.30	25	26.84	CHANGED	hslLppIpsthpcLscoE+KlA-aILssscpshphSlsplAptuuVS-uollRFs+pLGapGFs-hKlpLup-lusp	................................h..plpp..t..h.p.pL..o..ps.E..cc.....lA.c....a.ll.p.ss.p.p...s....h.pho..lp...cLApps.s....l.S..puolsR.Fs+.+.l..Gap.Gap-....h.K..htLtpth...t.....................	1	359	791	1163
+3013	PF02796	HTH_7		Helix-turn-helix domain of resolvase	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.01	0.72	-4.10	14	3816	2012-10-04 14:01:12	2003-04-07 12:59:11	10	39	1793	24	542	3351	302	44.90	28	23.91	CHANGED	GR.pphscp..p......hsplhpLhppG.hshpplActhsloRsTlYRhhsst	...........................GR......p..hspp.....p...........hpp.lh...c.h..h....p....s...G...h.....s..hp..plAcphsl.oR..s.TlYRhhtt.t........	0	153	335	445
+3015	PF00165	HTH_AraC	HTH_2; 	Bacterial regulatory helix-turn-helix proteins, AraC family	Sonnhammer ELL, Griffiths-Jones SR, Studholme DJ, Schleif R	anon	Prosite	Domain	In the absence of arabinose, the N-terminal arm of AraC  binds to the DNA binding domain (Pfam:PF00165) and helps to hold the two DNA binding domains in a relative  orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerisation domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilised when AraC activates transcription, and  hence AraC ceases looping the DNA when arabinose is added [1-2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.91	0.72	-4.00	75	482	2012-10-04 14:01:12	2003-04-07 12:59:11	18	29	353	4	136	54828	2557	37.30	26	22.38	CHANGED	lp...psp.hsltclApphuh.Stshhp+hF+pthGhoPppahp	...............................plpplAppsGh..S..t.pa.F....p+hF.Kchh.GhoPtpah..................	0	48	84	114
+3016	PF04204	HTS		Homoserine O-succinyltransferase 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.84	0.70	-5.69	77	2128	2012-10-03 00:28:14	2003-04-07 12:59:11	11	3	2054	3	324	1318	572	290.40	50	95.62	CHANGED	PI+IPcsLPAhclLppENIFVMs-sRAtpQDIRPL+IhILNLMPpK..lpTEsQlLRLLuNT..PLQl-lsLl+hsoHpuKNTst-HLppFYcsF--l..+sc+FDGhIITGAPlEplsFE-VsYWcELpcIh-WocspVpSTLalCWGAQAuLYaaYGlsKh.LspKhaGVFpHp..shp.ps.LhRGFDDpFhsPHSRaT-lpcc-l...pptssLplLucS--sGshlltscct.RplFl..hGHsEYDspTLppEYpRDhtpGh.s.....hplPtNY...........................aPsDDPsppPhspWRSHApLLFuNWLNYhVYQpTPY	.....................................................PI+lsccLPAhphLcpENlFV.MsppR.Atp....Q....-IRPL+llILNLMPpK..lpTEsQhLRL..LuNo....PLQV-lphL+hco+pS+NTssEHLpsFYpsF.....--l..ccppFD.....G.hIlTGA.PlEtlp.FE...-VsYWp.Elpplh-WuKsH..Vp..S..TLalCWuAQAuLhhhYG.l...sKhshscKl.GVYp...H..c...h..l..c..s...p...s...h..L......h......RGF.D....D......s..Fhu.P...HSR.as-hst.ppI...pp.hs-.L.cILuco-.-.u.GshLhso+Dt..RplFl..hGHsEYDspTLspE....YhRDlptGl..s......sc..l..PhNY............................FspsDP...pp.pP.pssWRSHusLLFsNWLNYhVYQ.TPY...................................................	0	87	185	247
+3018	PF04955	HupE_UreJ		HupE / UreJ protein	Bateman A, Eberhardt R	anon	COG2370	Family	This family of proteins are hydrogenase / urease accessory proteins.  The alignment contains many conserved histidines that are likely to be involved in nickel binding. The members usually have five membrane-spanning regions.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.75	0.71	-11.52	0.71	-4.98	80	494	2012-10-02 18:22:22	2003-04-07 12:59:11	7	4	398	0	191	653	600	177.30	34	89.46	CHANGED	lsh..h...hhsssAhAHsupst...su...GhhuGhsHPlhGhDHLLAMlAVGlWu.uhhus.....+uh.........ahl....PhuFlusMll.GusLulsGls.lPhVEssIusSVlllG..LllA......hst+lPh....ssuhullulFAlFHGaAHGsElsususshh......YshGFslATuhLHhsGlulGhhltpttt........lhRhsGuslAssG.hhL	...................................h..lhhhsssAhAHsuts.........ts.......Ghhu....GhhH..Pl.hGhDHLLA..MlAVGlhu..uthtt.....ptt................hhl....Ph..s..F....l...s...s...M..ll...G...u...h...l...G...h...t...G...l...s...l.....P.....h...sEssI.u.sSl.l.llG....l.h.lu...................hs..h....c..h.sh.................hh.u...h....sls.....ul.FA..lFHGaAHG...s...E....h.....ss....susshh............YssGFshuou.h.L.as.s.Ghu.l.uhhl..tphts.................hhRhsGu.shAhhGhh.................................................................	1	43	101	146
+3019	PF01455	HupF_HypC		HupF/HypC family	Bateman A	anon	Prodom_3112 (release 99.1)	Family	\N	19.60	19.60	20.50	19.90	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.26	0.72	-3.98	170	2243	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	1433	6	492	1128	72	69.50	44	76.37	CHANGED	MCLulPucll....pl........p..sphAh...l........-hs.G..lp+clslsLls.-......splGDa.VLlHlG..aAl.pclDccEApco.Lphhp	............................MClGlPupll....sl.........-..tphAp.....V........-.ls..G....lpR..-VslsLlsp.......stlGpW.VLVHVG..FAh.uhIDEpEAccTLcsL...........	1	163	329	421
+3020	PF04809	HupH_C		HupH hydrogenase expression protein, C-terminal conserved region	Mifsud W	anon	Pfam-B_3701 (release 7.6)	Family	This family represents a C-terminal conserved region found in these bacterial proteins necessary for hydrogenase synthesis. Their precise function is unknown [1].	21.20	21.20	29.80	21.30	20.00	21.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.44	0.71	-4.35	36	1273	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	541	2	95	481	8	110.40	37	72.84	CHANGED	GlhNAPslLsEIt-+sts...htsustsHVINLTLLPhostDhsaLsphLGpGslsl.LSRGYGsCRlsuTuhhpVWpVpaaNShDslIL-TlElsslPcVAhAAsEDlpDStcRLpEllc.slp	...........................................hsLhpELhtplpp...........ss...scslsls.LPlstsD...RtFLspLLGcGpls..l...pp........t..s..hu....ESc...IppThhsGlW+VRphss.h..cp.hLhD.plEluslP.p.sh........A.u.tD.................h...................	0	30	56	72
+3022	PF01750	HycI		Hydrogenase maturation protease	Bashton M, Bateman A	anon	Pfam-B_548 (release 4.2)	Domain	The family consists of hydrogenase maturation proteases. In E. coli HypI the hydrogenase maturation protease is involved in processing of HypE the large subunit of hydrogenases 3, by cleavage of its C-terminal [1].	20.60	20.60	20.80	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.51	0.71	-4.60	27	2632	2012-10-01 20:58:29	2003-04-07 12:59:11	13	8	1344	10	545	1351	63	127.40	28	73.29	CHANGED	l+llEtLpctht..t......pVpllDuGTtuh.Ll.hlpp....hc+llllDAlch.GhcPGplchlcs--lsp..hthc.hShHphshtpsLphhp.htph.tclllhthpshph--...hshsLoptVcpslspAlchllpt	........................................chsctL..ttpht.st..........tlcllDGGTtu.h.p.L.l.s.hlpp......sc+LlIlDAl....ch..G...h..sP.Gsl.......hh.......h.c.......s....-..........c..l.....ss.....hh.s....t......t......h.......S.....s...HphshsclLs..hh..c..h..p.....G..p.h..P.tcl..hl.lGlp..P.p............l..c............thsL.....ot.lcst.ltsshpth...t...........................	0	173	357	462
+3023	PF01968	Hydantoinase_A	Hydantoinase; 	Hydantoinase/oxoprolinase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the enzymes hydantoinase and oxoprolinase EC:3.5.2.9. Both reactions involve the hydrolysis of 5-membered rings via hydrolysis of their internal imide bonds [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.70	0.70	-5.31	61	2437	2012-10-02 23:34:14	2003-04-07 12:59:11	13	36	1379	6	1233	2598	1387	281.50	29	34.74	CHANGED	RssTsllNAhLtPlhppalptlpstlcptsht........................................splhhhpusGGlhshcpupppPlcslhSGPAuGllGAuh.....hsGhc........shIshDhGGToTDluhltpGpschsppstl............uGhhsph.hlclpolusGGGSll.hhtpstth+.lGPpSuGspPus...............................................................hshshGGp.hTlTDAslhLGcls.p.hh.....tt......phs.thh.t.hut.h............................................pplApthlplsstphscul+hl.................................................................................s.ppshsspshslsshGGuu.shasstlA..ctluhppllh..hs.uVhsAlGhhlAclptch	.............................................................................................................................................................RssTsllsAhltPhhppa...lpph....p...p...t...lp...p....t..t.h.t..............................................sp.lh..hhp.us.GG.lhshpp....hp.t.h..cslhS.GPA....u..Gl.h.Gushh...............thsu...h.p.........................................ss.lshDhGG.......ToTDl.u.h..l....s.......tG......p............c....h.s...ps.th..............uGhthp..hsh.lcl.polusGGGSll........h.......p...........s......u.....t........hp..VGPcSAGupPGP..................................................................................................................ssat.....t...G.G.............h.Tl..T..D.As......l...h.L..G.t.ltsp....hs.........ttt.....ls.ths.t..t....th....tt.lut...lsht........................................spps..At.uhlcluspphspsl+tl...............................................................................................................s.t.pG..hcs.p...p..hs.Lh.sh.G.GuG.....s.ass.tlA......ctlG.....hp.....p.l.....ll..hs....ul.huAhGhulAclt...h......................................................................................................................................................	0	388	797	1050
+3024	PF02538	Hydantoinase_B		Hydantoinase B/oxoprolinase	Mian N, Bateman A	anon	COGs	Family	This family includes N-methylhydaintoinase B which converts hydantoin to N-carbamyl-amino acids, and 5-oxoprolinase (Swiss:P97608) EC:3.5.2.9 which catalyses the formation of L-glutamate from  5-oxo-L-proline. These enzymes are part of the oxoprolinase family and are related to Pfam:PF01968.	21.40	21.40	21.90	22.50	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	527	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.60	0.70	-6.28	6	1619	2009-01-15 18:05:59	2003-04-07 12:59:11	9	25	1011	0	830	1658	1539	505.30	33	58.32	CHANGED	hDPIhLE.lFpshatsIAEpMGhhLcpTAhSsNIKERLDFSCAlFDusGsLVAsAsHIPVHLGSMupuVKthl+.thcs..plcsGDVhlsNDPYhGGTHLPDITllsPlFpsst..llFaVAuRuHHADlGGlTPGSMPssSpplapEGhlIss.phLscsGchp-phhc.plhlcss..a.....sRsPcsslu.DL+AQIAANpcGIcpltchI-caGhcsVttahs+lps.uEcul++tIsclss..Gphca.......chDsstpIslplplchcptphhlDFoGTSsQscsshNAspulssuulhYsh+sLlssDIPlNcGCh+PLpIllPcGollsP..cpPAuVsuGNVETS......QtIsDslauAhs......V.AsSpGoMNNlTaGsts............asYYETIuGGoGAu......sGhsGssAVaopMTNohhTDhEllEpcYPlLlpEaulRpsSGGtGKaRGGsG..lVRphcFhpshololLusRR+luPaGltGGpsGusGcN.hlh+ssGsclclsupsolalp....PGDR..............................llIcTPGGGGYG....hp....hcD	....................................DPlhLp.lhp.pthhuIAEpM.uhsLp+TuhSssI+EchDaSsAla...s.s......c.G...p...l..l.A.p.A..s.p.l..PlHl.G.........o.M...s...t...sl.c..t.hlc...th.t.s..........slc.sGDVhlsNcPa..t...G...G.....o....HLPDlolls..PlF.............t.........p.........s....p..............l...............l...........h....alA.u+uHauD.................lGGh..sPG.Shs.spuppla.pEGlh.lss.h+Ls...c....pG...p.h..p..-p.hlp.......hl....hpss...........................R....sspp.shu.DLpAQ.lAA..s..pp....Gh..ppltcllpcaGh-.sV.psh......hptl............pcpuEpssR.ph.l....p..p..l....s....c...............G.p....h....p.h...s.....................s.th.D..s..s.....s.....lp..l...pl..s..l......s.......h......p.....s.............s....p...........hhhDFsGT...us.p.s...s..shN.....u....s......h......u......s.....s..h......u....u.....l...h......a.....s.....h..+......sll.....s........s......-......lP..h.....N.p.............G.sh.pPl.plhl.P..c..Gol.....L...s.P........phPA...A..V..su...u.....s....s...s..S........p...t..ls..cslh.tAhs....................................s..A.u..u...p.....G..s...h.......N....s.....h...s...h.G..stp.............................a..t.h....a...E..o.....l...u...G.G...s....GAs..............sshcGt..s...u...l...p..s...p..h..o.....N.o...p...h..T.s.sElhEt.caP.ll..l.cp.ap.lR.t.s..S.G.GsGcaRGGs..G....sh.R....p..l....c..h..h....p..s....h....p..h..s.l..l..u....p..R...p..h..h..s.....P..a..GltG.....Gts....G.......t.......h.......Gts....h.....l..h.....c.......t..............s..................s..........p.............h.......................p....l..........s...u..p...s..s...h...t..l.p........................s.GDh..............................................l.hl.T.P.GGGGaG.....t.........t..................................................................................	0	241	519	705
+3025	PF01185	Hydrophobin		Fungal hydrophobin	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	21.50	21.40	21.20	21.30	hmmbuild  --amino -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-11.33	0.72	-3.53	69	519	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	203	0	178	496	0	81.40	33	62.51	CHANGED	C.ss..uslpCCNpspsuss.........hhsslLu.LLGhsht........shsuhlGh.sCoPlsl...l.ul.uss.......u.Cssps..VCCpss...shs.GLls.lG...Cs...Pls	.......................................C..ssuplpCCNpsppuss........s.......hsshLs.L.l.G.h...hs........shpu.h.lGh..pCoslsl......l.sh.uhs....................spC...ppp...sCCpss.....s.s...G.Lls.lG....C.sl.............................	0	98	127	156
+3026	PF01155	HypA		Hydrogenase expression/synthesis hypA family	Finn RD, Bateman A, Yeats C	anon	Prosite	Family	Four conserved cysteines lie either side of the least conserved region.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.63	0.71	-4.39	169	2158	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	1453	7	454	1106	89	112.50	38	96.54	CHANGED	MHEhSlspullchlpc.pApppt.....sp.+VppVpLclGpLosVps-sLcFsF-shscsT.................................lscsAcLpIpphsspshChsCupphplpphh...................................CPpCGuhpl.pl.hsGcEhplcplEl-	.........................MHEloLspshlEllppp.Appp.s.......sp..+VssVaLcIGshSsVEssulpFsF-.ls....s.c..G.T.................................lAc.Gs.cLclp.tsApsaChsCsphspltppp....tp................................CPpCpu.p.p.l.pl.ssG.-pLpl+pIEl........................	0	154	306	388
+3028	PF01924	HypD		Hydrogenase formation hypA family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	HypD is involved in hydrogenase formation. It contains many possible metal binding residues, which may bind to nickel. Transposon Tn5 insertions into hypD resulted in R. leguminosarum mutants that lacked any hydrogenase activity in symbiosis with peas [1].	25.00	25.00	27.80	27.80	22.60	22.30	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.09	0.70	-5.71	129	1488	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1407	2	399	1039	96	349.00	49	96.11	CHANGED	Dsph..spt.LhcpI.pphsp........c.shplMEVCGGHTHoIh+aGlcpLLP....pslchlHGPGCPVCVhPhtcIDpAlpLA.....tpssVIlsTaGDMhRVPGSpt...............................S.LhpA+A....cGA.DVRhVYSPhDAlclAccNP-+pVVFFAlGFETTsPsoAhslhpAt...........ttslcNFslhssHlllPPAlcslLp..ss.......p.splcGFluPGHVSslhGscsYc.lsccaphPlVVuGFEPlDlLpulhhllcQlppG.....cscl-N.pYsRsVpt-GNhtApphlscVF-lp-p.cWRGlGhIPpSGLpL+ccaupaDAcp+Fs.....ls.....thpss-spu...CpCGclL+Ght+Pp-CtlFGpsCTPpsPlGuCMVSoEGACAAYYpYs..ph	......................p....shpLhcclccpss...s.....+PlpIMEVCGGHTHuI.hKaGLcpLLP....c.s.l-hIHGPGCPVCVhPhuRIDsslclA.....pps-VIhsTFGDhhRVP.Gppu..............................................SLlpA+A......cGA.DVRlVYSPhDALclApcNPs+...cVVFFulGFETThPsTAlsLppAc...........tcslpNFhhaspHlpl.PslculLc....ps..........s..stIDuFLuPGHVShllGscsYphlAp.............ca....pp...........PlVVuGFEPLDlLpullMLlcQhhtu......cscVEN.QYpRlVscpGNhhAQphls-VFpl.sss.EWRGLGhItsSGlcLps-YppFDAEt+Fc......ss...............sp.p.ss-.s.tCcCG-VLpGhsKPppCsLFGpsCsPpsPhGuhMVSSEG.ACAAaYpYppt....................................	0	137	272	345
+3029	PF02494	HYR		HYR domain	Bateman A	anon	[1]	Domain	This domain is known as the HYR (Hyalin Repeat) domain, after the protein hyalin that is composed exclusively of this repeat.  This domain probably corresponds to a new superfamily in the immunoglobulin fold. The function of this domain is uncertain it may be involved in cell adhesion [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.74	0.72	-3.97	19	1816	2012-10-03 16:25:20	2003-04-07 12:59:11	11	329	171	0	1519	1518	549	80.40	30	16.53	CHANGED	VDTsPPsV.sCsss.lhpsVElGsssspVhasEPTAsDsuG..pssLloRospPGD.FPVG.posVTYsapDsuGNpA.sCsFTlsV	.........................................DspsPsl..sC.....P......ss...hphs..s......s........u.....p...s...s.....s.....s....V....s...a...s...t...P.....s....A...o.DNss..............s.s.s..l...s....s.........s....t..s....s.........G...s...........h..Fs.....l....G....s......s.....s...V..s..You.s.D.s.uG.Nsu..sCs..FpVsV..................	0	1239	1292	1437
+3031	PF01608	I_LWEQ		I/LWEQ domain	McCann R, Bateman A	anon	[1]	Family	I/LWEQ domains bind to actin. It has been shown that the I/LWEQ domains from mouse talin Swiss:P26039 and yeast Sla2p Swiss:P33338 interact with F-actin [1]. I/LWEQ domains can be placed into four major groups based on sequence similarity: (1) Metazoan talin; (2) Dictyostelium TalA/TalB Swiss:P54633 and SLA110; (3) metazoan Hip1p Swiss:O00291; and (4) yeast Sla2p Swiss:P33338. The domain has four conserved blocks, the name of the domain is derived from the initial conserved amino acid of each of the four blocks [1].	36.30	36.30	36.70	36.30	35.80	36.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.93	0.71	-4.27	22	586	2009-01-15 18:05:59	2003-04-07 12:59:11	12	37	239	11	325	542	0	147.60	43	10.97	CHANGED	FY+KNsRWTEGLISAAKAVAtATshLlcsAssllp....ups....o.E.pLIVASpEVAASTAQLVAASRVKAshsSpspppLppAS+sVopAscsLVppspshhpptcp.....pcslDhspLo.tphKstEMEQQVcIL+LEppLptAR++LuplRKpp.Ypps	............................Ytcsu..pWoEGLISAAKuVAtusssLl...EuAss.llp....Gcu..............s.E.cLIsuu+pVAASTAQLVsAo+....VKA..sh.sS.c..s.h...c+Lp...............t............A...........u+uVs.........pAscsLVp.uspsutpp..ppc.................p-s..hc..hs.p...hshhph+spEM-sQs.......c....lLclEppLpptRp+LuplR+p.p.Yp..h............................	0	97	141	228
+3032	PF04568	IATP		Mitochondrial ATPase inhibitor, IATP	Kerrison ND	anon	DOMO:DM04419;	Family	ATP synthase inhibitor prevents the enzyme from switching to ATP hydrolysis during collapse of the electrochemical gradient, for example during oxygen deprivation [1] ATP synthase inhibitor forms a one to one complex with the F1 ATPase, possibly by binding at the alpha-beta interface.  It is thought to inhibit ATP synthesis by preventing the release of ATP [2]. The minimum inhibitory region for bovine inhibitor (Swiss:P01096) is from residues 39 to 72 [2]. The inhibitor has two oligomeric states, dimer (the active state) and tetramer. At low pH , the inhibitor forms a dimer via antiparallel coiled coil interactions between the C terminal regions of two monomers.\	At high pH, the inhibitor forms tetramers and higher oligomers by coiled coil interactions involving the N terminus and inhibitory region, thus preventing the inhibitory activity [1].	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.46	0.72	-3.98	34	329	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	226	8	221	316	0	83.00	28	76.51	CHANGED	M......hphsh.........hp.....h.h.h.hthth.t.stGss..GAs.+uGG......tuGsuFsKREtApE-hYh+p+E+EQLtpLKc+lpc....pccclccL-ccIc	......................................................................h.....t..Gph.......Gus.+....ssG...................t.uG......s.uFuK+EtAp.....E-hYh+p+-+E.pLpp.L...Kc+hcc.......pppplcphpptlp...............................	0	69	114	179
+3033	PF01749	IBB		Importin beta binding domain	Bashton M, Bateman A	anon	Pfam-B_544 (release 4.2)	Family	This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates  formation of the importin alpha beta complex; required for classical  NLS import of proteins into the nucleus, through the nuclear pore  complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain [4].	23.80	23.80	23.80	24.00	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.55	0.72	-3.82	18	914	2012-10-11 20:00:59	2003-04-07 12:59:11	15	16	301	41	568	813	4	92.30	32	18.60	CHANGED	pssscsphRhppYKspu.hcs-EhRRRRcEstVElRKsKREEpLhK+Rplsh.tppt.p...psphsss.t...ssplppsh.h..pulhScD.ppQ.Lpusst	............................t....hsphRhppaKspu.hcs.........-EhRRR.RpE.sV...ELRK.sKR-E.pLhKRRNl..s......h.....p..p.......ss.s.p............tsp.pssh.t............pph...s....p.........h..............psl..S.ss.t.Qltusp.t.......................................................	0	157	244	397
+3034	PF03617	IBV_3A		IBV 3A protein 	Finn RD	anon	Pfam-B_3183 (release 7.0)	Family	The gene product of gene 3 from Avian infectious bronchitis virus. Currently, the function of this protein remains unknown.	25.00	25.00	89.10	89.00	18.60	17.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.99	0.72	-4.22	6	81	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	15	0	0	79	0	56.80	82	99.74	CHANGED	MIQoPTSFLIlLILLWhKLVLSCF+ECllALQQLIQVLLQIlNsNLQSRLlLWHSLD	MIQoPTSFLIVLILLWCKLVLSCF+ECVlALpQLIQVLLQIINSNLQSRLLLWHSLD....	0	0	0	0
+3035	PF03622	IBV_3B		IBV 3B protein 	Finn RD	anon	Pfam-B_3190 (release 7.0)	Family	Product of ORF 3B from Avian infectious bronchitis virus (IBV). Currently, the function of this protein remains unknown [1].	25.00	25.00	30.60	29.90	21.20	18.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.21	0.72	-3.99	7	88	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	17	0	0	82	0	63.20	73	99.30	CHANGED	MLsFEtlIETGEpVlQQISFsLQHISSVLsTplFDPFEsCYYRGGsaWElESA--hSGDDEahE	..............MLDFEsIIETG-QlIQQISFsLQHISSVLsTElFDPFEsCYYRGGsaWElES...AD-hSGDDEalE.......	0	0	0	0
+3036	PF03620	IBV_3C		IBV 3C protein	Finn RD	anon	Pfam-B_3232 (release 7.0)	Family	Product of ORF 3C from Avian infectious bronchitis virus (IBV). Currently, the function of this protein remains unknown.	25.00	25.00	25.50	58.60	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.05	0.72	-4.09	3	126	2009-09-10 22:14:47	2003-04-07 12:59:11	8	1	17	0	0	128	0	92.10	87	87.33	CHANGED	MhNlLuKSLEENGSFLTuVYVFlGFVALYLLGRALQAFVQAADACpLFWYTWVlLPGAKGTAFVYNaTYGK+LNNPELEoVIVNEFPRNGWNN	...hhNlLNKSLEENGSFLTAlYlFVGFlALYLLGRALQAFVQAADACCLFW.YTWVVVPGAKGTAFVYKHTYG+.K.LNNPELEuVIVNEFPKNGWNN...	0	0	0	0
+3037	PF04629	ICA69		Islet cell autoantigen ICA69, C-terminal domain	Mifsud W	anon	Pfam-B_5314 (release 7.5)	Domain	This family includes a 69 kD protein which has been identified as an islet cell autoantigen in type I diabetes mellitus [1]. Its precise function is unknown.	31.40	31.40	31.50	31.50	31.00	31.30	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.73	0.70	-4.40	6	145	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	51	0	70	148	0	173.60	37	43.48	CHANGED	PYEFTTLKSLQDPscKLspc...cK-cpppsspsusp.scpLISLE-t+..cEouo..s-cthu.lSuh-ch.hcsos.GAhD-LLDhKs-E.hhht..lPtDPLEPEsuDKDEhpLLN-ILSuSSL-suEhopEWAAlFGDP..pLtsPcP.ShGss-.-.+ssoSSGFLPSQLLDQsM+DLtuSlpsWsupptop.....sps.Psss.......QpPAK.......uupDLoAWasLFADLDPLSNPDAVGKTDKEHELLNA	.............................................................................................................................................................................................p.....t...p..t.......p....................t.hl.............t...........................................................................h......hss..c..-sh-K.-h.hLsplhss.uu...tpu-aopEhtssFG..ss........tp.t.s...shu.t..................tp.sotFLPSQLh......D..s..hp..htuu.h............................................................................p.pPtp..................u.spDhoAWFsLFADLDPLSNPDAl.G+o.Dc..ELLNA......................	0	10	16	34
+3038	PF03921	ICAM_N	ICAM_N-terminal;	Intercellular adhesion molecule (ICAM), N-terminal domain	Finn RD	anon	DOMO:DM01682;	Family	ICAMs normally functions to promote intercellular adhesion and  signalling. However, The N-terminal domain of the receptor binds to the  rhinovirus 'canyon' surrounding the icosahedral 5-fold axes,  during the viral attachment process [1]. This family is a family that is part of the Ig superfamily and is therefore related to the family ig (Pfam:PF00047). 	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.24	0.72	-4.51	5	218	2012-10-03 02:52:13	2003-04-07 12:59:11	9	28	36	23	89	253	0	89.10	36	19.09	CHANGED	pcsFpVpVcPcKslLssGGSlpVNCSToCspP-hlGLETsLsKchL-p.Gpu.WKtFpLSNVocDSshhCahsCuGsQpSuSoNITVYpsPEp	.........h.lplpPp.p.shV.h.GuSlhlNCS.T.s.Csp.P....p....h...h....G.LETp.LpK...p....ltp...Gsp...WttapL.s..slp..c..-.o.p.h.h.Cahs....C.u.s.p..Qpps.sssITVYphP-p.........	0	5	9	17
+3039	PF00818	Ice_nucleation		Ice nucleation protein repeat	Bateman A	anon	Pfam-B_2 (release 3.0)	Repeat	\N	20.80	20.80	31.80	20.80	15.40	20.70	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.76	0.72	-5.71	0.72	-4.50	110	1266	2009-01-15 18:05:59	2003-04-07 12:59:11	12	33	34	0	97	1330	0	15.80	74	44.84	CHANGED	GYGSTQTAGhcSsLTA	GYGSTQTA.utsSsLTA..	0	35	35	35
+3041	PF00656	Peptidase_C14	ICE_p20; 	Caspase domain	Bateman A	anon	Bateman A & Pfam-B_2524 (Release 8.0)	Domain	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.80	0.70	-4.68	115	4033	2012-10-03 02:24:44	2003-04-07 12:59:11	17	280	992	455	1901	4284	706	230.40	15	47.36	CHANGED	thALlIssspaspt..........sphpGstsDscslpphL.ppl.G.....apVps..........h.ps..................................................................................hotpphppt.lpphstptc.....ssD...shlhhhhuHG..tp........s..hsh.............Dsph..l...sl-t................lpshhpshps.sLtsKs+.lhllpACRusphspthttttstt............................................................................................................................................................................................................................tsshtphsstsDhlhhhuosssthShcs.................sspuShahpuLsphl......t.......hpltslhspVppplt................t.......................ttcQhPph.suhhpcphhh	..................................................................................................................................................................................hslll.s..p.ta..tt.....................tth......p...u..s.....t.D.s.p....tht..p...h..h...p..p..h....s...........a..psps..........h..ps.........................................................................................................ho.t.p.p.l.......hp......t...l..p..p...hhp.psp..............ssD...............shhhh..............h..........h..uH.G........tp................t.........t.h..................-sth......l..........sh-t...........................................lts......h.ps......h........s...t..........l....s..p...s....+...l............hh.l..pu....C...+.....u..s.s..h.....ph..h...h...t........................................................................................................................................................................................................................................................................................t....ht.t.h.....s.....s....s.h...l..h..h.h...u...s......h..s..s.....t...h.u.hcs.............................ttts...uh.ahptlhphl.....................................h..phh....ht.tth..............................................................h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	653	1049	1463
+3042	PF00463	ICL		Isocitrate lyase family	Finn RD	anon	Prosite	Domain	\N	19.50	19.50	19.50	19.50	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.93	0.70	-6.29	7	4174	2012-10-10 15:06:27	2003-04-07 12:59:11	16	13	1846	69	1148	4424	4281	225.10	28	93.61	CHANGED	EVtElcKWWossRW+tTKRsYoAEDIss+RGsl+.lpYsSs.tAcKLa+lLcc+ptptssShTaGsLDPstVoQMAKYLDolYVSGWQsSSTASoSsEPuPDLADYPhsTVPNKVEHLahAQLFHDRKQpEERhphscpc..Rtph.s.lDYLRPIlADADTGHGGlTAlhKLTKhFIERGAAGIHIEDQusuTKKCGHMAGKVLVPlQEHINRLVAIRhpADIhGo-LLslARTDuEAATLITSoIDhRDH.FIlGsTNPsh..tsLsslMstA.htGtpGspLtslEs-WhtKAsLKhFpEAVlDtIptus...hsNKpthltca.ppsp.hpphst.EA+tlAcclhGp-IaFsW-hsRsREGaYRapGGspCulsRuhAaAPYADLIWMESphPDatQA+EFA-GV+utaPcQhLAYNLSPSFNWppAMssD-.QcTaIpRLucLGYsWQFITLAGLHTsALhscsFA+sYup.pGM+AYuppVQpP...EhcsGV-VVpHQKWSGAsYlDtlL+hlpGGVoSTAAMGtGVTEDQF	..........................................................................................t........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	314	663	947
+3043	PF03517	Voldacs	ICln_channel;	Regulator of volume decrease after cellular swelling	Griffiths-Jones SR, Coggill P	anon	PRINTS	Family	ICln is a ubiquitously expressed multi-functional protein that plays a critical role in regulating volume decrease in cells after cellular swelling. In plants, ICln induces Cl- currents [1,4,5], thus regulating Cl- homoeostasis in eukaryotes [2,3]. Structurally, the fold resembles a pleckstrin homology fold, on of whose roles is to recruit and tether their host protein to the cell membrane; and although the surface charges of the ICln fold are not equivalent to those of the PH domain, ICln can be phosphorylated in vitro and the PH-nature of the domain may be the part involving it in the transposition from cytosol to cell membrane during cytotonic swelling [1].	22.10	22.10	22.20	23.30	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-11.14	0.71	-4.32	115	359	2012-10-04 00:02:25	2003-04-07 12:59:11	8	8	280	1	243	349	2	133.60	25	52.92	CHANGED	GsLalssp.plhWh.s.............t...............................spGhulsYsuIoLHAlp+.........................shsp.slYhQhp.....................................................................ttssspsssppsppsssElpllPsss................................st......lcslapAhspCus.LpPDss.......t-pptp...t..tptptp.shhhps	....................................ssLalspp....plhWhs.........................................................sshGhul.YssIoLHAls+..t......................shsp.slYh.ls...............................................................................................................t........ttptpppssc-ptpthsEhpllPsst....................................sp...........lcshapAhspCps.LHPDPp...............sp-s.-cc....t...............ttth.......................................................................................	0	73	122	187
+3044	PF04140	ICMT		Isoprenylcysteine carboxyl methyltransferase (ICMT) family 	Wood V, Finn RD, Bateman A	anon	Pfam-B_15304 (release 7.3) & Pfam-B_5114 (Release 8.0)	Family	The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.26	0.72	-3.79	12	1448	2012-10-01 22:51:20	2003-04-07 12:59:11	9	8	1272	1	481	2287	1176	94.30	31	44.00	CHANGED	hlsh..hlhuphhRhhshhohGphasp+lhh..hssHplVpsGlYpalRHPsYhs.hhhplus.sLlsss..huhlhhshsshhha..RIcpEEpsLhp	.....................................hsh..hl..hlhu....h.hhh.h..sh..p.p.L..G.p..h..W..o...h.+........l..hl..........hss..H...p.lV..s...pGlY+..hh+HPsYh..h...............l.....l.........p....lh...s....h.h.....L...L...s..p...u.....h.......h........s....s.....l...l....h.....h.s.....h.....h....s..h...h.La..hR..I..c.p.EEphL..t.......................................................	1	166	278	396
+3045	PF03971	IDH		Monomeric isocitrate dehydrogenase	Bateman A	anon	COG2838	Family	NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes [2].	25.00	25.00	27.90	27.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-13.26	0.70	-6.17	5	1265	2012-10-02 21:08:39	2003-04-07 12:59:11	9	3	1189	11	297	1040	630	682.90	61	98.77	CHANGED	TIIYTlTDEAPALATYSLLPIV+AFAcsAGIcVETSDISLAGRILAsFPDaLTE-QRVsDsLAELGELspoPDANIIKLPNISASVPQLKAAIKELQ-KGYAVPDYP-DPpTDEEKAVKtRYDRIKGSAVNPVLREGNSDRRAPtAVKNYARKaPHSMGAWSpsSKSHVAaMcuGDFFuSE+ShTlucAssV+IEFluK-GsVcVLKcpVALp-GEIIDosVMSKKALtsFaEcQlpDAKupGVLFSLHlKATMMKVSDPIIFGHAV+VFYK-VF-KaG-LF-pLGVNVNNGlGDLYAKIcSLPAuQRsEIcADIpAVYA+pP-LAMVDSDKGITNLHVPSDVIVDASMPAMIRsSGQMWGsDGKtKDTKAVIPDSoYAGVYQslIDFCKpHGAFDPTTMGSVPNVGLMAQKAEEYGSHDKTFElsADGVVRVl.DAsGcVLhpHsVEAGDIWRMCQTKDAPI+DWVKLAVTRARlSsTPAVFWLDPsRAHDsELIKKVcpYLKDHDTsGLDI+IMSPlEAh+aSLsRL++GpDTISVTGNVLRDYLTDLFPILELGTSAKMLSIVPLMAGGGMFETGAGGSAPKHVQQllEENHLRWDSLGEFLALAASLEHLGlKTGNsKAKVLAKALDsATGKLLDNNKSPSRKlGELDNRGSHFYLAhYWAQALAAQs-DA-LpA+FAPLAKALTEcEAsIVAELNuVQGKPuDIGGYYAP-s-+sAsVMRPSsTFNAAL-u	......pIlYThTDEAPuLATYShLPIlcuFspsAGIsVcTpDISLAGRILAsFP-hLsE.....-Q+lsDsLAELGELsppP-ANIIKLPNISASlPQL+AAIKELQspGYslP-YP-.-PpoD....EE+pI+ARYsKlhGSAVNPVLREGNSDRRAPtuVKsYA+KpPHp.M.G....t.W.ot.s.SKoHVApMp.pGDFausEKShsl......s..p..usslcIEh..l....sp....c....G.s...p.pVLKpslsLpsGEllDuo.hMStcALppFhtcpltcAKpp.sVLFS.LHlKATMMKVSDPIlFGHAV+lFa+-lFsKauchhcplGlssNNGlu-lau+lp.s.L.Pssp.psEIpusl....pusa.s..p..pPsLAMVsSDKGITNLHVPSDVIVDASMPAMIRsuG+MWss-G+.pDTpAVIPDpoYAslYQssI-.C+ppG.AFDPsTMGoVPNVGLMAQKAEEYGSHDKTFpl.stsGslcll......s......t......s....GpVL..hpppVEtGDIWRhCQsKDAPIpDWVKLAVsRARhossP.......AlFWLDtpRAHDsplIpKVppYLt-....H.....D....TpGL...-IpIhuPh-AhpaoLcRl+cGpDTISVTGNVLRDY.LTDLFPILELGTSAKMLSIVPLMsGGGhFETGAGGSAPKHVpQhlcENHLRWDSLGEFLALusSLE....alu..pp..s......s..NsKAplLAcsLDpAsuchL-ssKSPuRKlGE.lDNRGSHFYLAhYWAptLAtQscDs-LtspFuslAptLspsEppIlsELs.ssQGpssDlG..GYYtsDst+sstsMRPSsThNshlp.s............	0	77	185	259
+3046	PF01231	IDO		Indoleamine 2,3-dioxygenase	Finn RD, Bateman A	anon	Prosite	Family	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.40	0.70	-6.05	39	516	2012-10-01 19:57:26	2003-04-07 12:59:11	13	11	214	4	368	501	538	358.10	28	79.96	CHANGED	s.h.sLp-YtlS.cpGFLPtp.PLccLP.-.YYpsWEpls...psLPsL.............lts.+plRphV-.plPlLsssp.L....psct.EhRRAYhlLuFlsHuYlWus..spPpc.....................................hLP.sluhPhlclSccLtLPPlhTYAulsLWNa+......htss......shhsh-NL..sslpoFTGohDE.pWFaLVSVhlEtcuu.slphhlsulpAsp.ts-p..ttlspsLpplupslcclsplLpRMaEps-PplFYaplRPaLuG.KsMsshGLP.pGlhY.................-....uspsp.+p...YuGGSNAQSSLIQhhDllLGlcHpssu...............................................................pssFlpEMRpYMPssHRcFLpclpp...................................ssslRpYVhsppsst...tLptAYssClttLpsFRDpHIQlVoRYIlhsu+cst.tt.s.....................................ppcsssht.+GTGGTsLlPFLKQsRD-Ttcssh	..................................................................................httatls.ppGFls.................P..l..p..pLP.......apsWpplh....ppl..sth...............................l.s...tplRt...h.l.c....ph.....P.hL..s..s..pt...L...........pspt...thptA.ahh.....L.......ualspuY..l....at...t........ppstp..............................................................hLPtsluhPhhplup.............p.............Lt.l.P.P.hh...s.Y.A.s.hs.....L.hNap......h...hsss.....................t.h.phcNl.........phl.h..sFps....s.....sE...phFhLlslhhEttuushlphhhp..slp.......u.......hp....psst...............ttlhpsLppltpslpc.ls.th...hppM.........hc...t.......s.cPp..haYtplR.s.altG.......p..s....t...h.....P...pGlhY...............................-.......s.s.p...t..p.hp.....apGsSsAQSSllp..hhDhhLslp.c.ss.....................................................................................ttalp-hRpYMPssH+pFLptl.pp..........................................ss...lRp..hs....t..........ptsp..................tlt.sYstslttltthRstHhphspcYIlh.upp..........................................................................................sout.s....hl...h........h........................................................................................................	1	115	201	288
+3047	PF02479	Herpes_IE68	IE68; 	Herpesvirus immediate early protein	Mian N, Bateman A	anon	Pfam-B_2276 (release 5.4)	Family	This regulatory protein is expressed from an immediate early gene in the cell cycle of herpesvirus. The protein is known by various names  including IE-68, US1, ICP22 and IR4.	18.70	18.70	18.70	20.30	17.90	18.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.59	0.71	-4.95	13	78	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	36	0	0	68	0	125.40	39	38.87	CHANGED	+sEYGssssstphRs....s+usGuFCussWpPDlsRLspDlNplFRsIspuuhsssssscsLRRsLhDhYlhGhsptR.s.ssWEpLLQLoPsQ.otsLRsTLR-lspRsststc.lpsssplstphaGsECDVS	.............................Pp.usssssthlR.....sRtstthsussWpPDlshlppslNpLFR.lhpsuhcspssuppLRRhlhDhYLMGYs+tRLs.psWppLLQlostp.uhpLRsTlR-lpuR.ststc.l..pt.ssl.sphaGsECDls.......	0	0	0	0
+3048	PF01008	IF-2B		Initiation factor 2 subunit family	Bateman A	anon	Pfam-B_1302 (release 3.0)	Family	This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterised as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The  crystal structure of Ypr118w, a non-essential, low-copy number gene  product from Saccharomyces cerevisiae, reveals a dimeric protein with  two domains and a putative active site cleft [2].	22.40	22.40	22.80	22.70	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.63	0.70	-5.42	18	3047	2012-10-04 00:26:15	2003-04-07 12:59:11	12	22	1567	43	1662	2957	1606	282.00	28	77.40	CHANGED	pl+GusslulsuhtsLhhhhpctp...hspsp-h.........hpplppthshLtsoRPouVsltsulchlhp...........tpshppscps.......................................llcpupphlp-.shpssptIuphutchI.........cDu-sILTas.sSus........sluVlpp.Ahppu.................+ch+VlssEoRP.thQG.+lsshpLhptGIsVTLlsDoulualMpc....lDpVlVGA-sIhpNGs.lhNKIGThplAllAKppslPFaVsA.phKFs.chthspplhhEtcsPpElhhhsssphh...................................................................slplhNPsFDlTPs-hIohlITEhGslsP	........................................................................................................................................lcGusshulsush.u....lh....h........h.....h....pp...h.t.............p.....t.t..h..................................hptlp...pth.p........hL...t..........s.........s......R......P.....o...u...l..s.....l.h......u.l.cp.hhp............................................t..t.....t...s....h.p..p..h...t...p.t.................................................................................................................................................................lh.ppup.p.h....h....p-....shts.scpI...u.p.h.u.h..p.h.l..................................p.s...s......t..s..lLTas..sous...................sh.u.s.lht..A...t..p.p.s....................................p...t..h...c.V.h.......s......s............E.....o......R.P....h................h.........Q.......G.....+...........h........o.A.................h.c..L.............t..........p..........t................G.................I..s..............s.TlI..s.D.s.s.s.uh..l.Mpp.................l....stV........lVG.ADpl.s.s.NGs.lsN......K......lGTht..lA.l..hA.........+...t........a.......s..............lPFhVsu..ss.phsh.p..h......s...s....p........p....l............l.......E.....+.s...s.p.E.l..h....p...h....t....s....t....p..h...s.s.t...................................................................................................................................................................s.hp.s.h..N.P....s.FDlTPschlo.u.llTEhGlh..............................................................	0	560	982	1379
+3049	PF00707	IF3_C	IF3; 	Translation initiation factor IF-3, C-terminal domain	Bateman A, Finn RD	anon	Pfam-B_629 (release 2.1)	Domain	\N	20.90	20.90	21.10	21.90	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.86	0.72	-4.24	150	4680	2009-01-15 18:05:59	2003-04-07 12:59:11	17	5	4531	3	1156	2821	2168	87.80	44	49.92	CHANGED	hlplKEl+hpPpI-cHDhpsKl+psp+FLcc.GcKVKlolpFR...GREhs+t-.lGtclLp+htpcl..p-luplEptP.+hEGR...pMhMhLu.P+p	.......h.lplKEl+h..pPsIDcpDapsKl+ssh+FL.-c.......GD...K.....VKlol...R...F.R....GR.....E.h..s....Hp-.......lGhclLp.Rltc-l....p-.lA...h...V.EptP..Kh..E.G.R...pMhM.lLA..P+................................................	2	397	751	978
+3050	PF01652	IF4E		Eukaryotic initiation factor 4E	Bateman A	anon	Pfam-B_1315 (release 4.1)	Domain	\N	21.00	21.00	21.50	21.20	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.19	0.71	-4.71	135	1579	2009-01-15 18:05:59	2003-04-07 12:59:11	13	11	412	47	834	1511	155	157.30	32	65.03	CHANGED	PLpppWohWap........stssp.......................tpsapssL+.l..............ssFsoVEcFWulYspl..P.ocLshts-a...............alFKcGI.+P.hWEDstNppGG+Wh..hphp..........................+p..........................ph-chWhchlLuhIGEph..pts...................--lsGlV....ls.lR..t.ptpp...............lulW.s+ss.....................ssppshhpIscpl+..chL..plssp..........h....papsH	..........................................................PLpppWshWa..............tt..s.p....................................................spsap..ss.l.+...l...............................tsFs.o.VEpF...W....s.lYs.pl.....hs.....o..pL...sh....t...s..Da........................a.lFKc..G..I.c...P..hWE..DstNtp.GG+Wh..lphp............................................Kt.................................................thDphWhch....lLuhI.GEpF..pps...............................--l.CGsV.......l..s..l.R.....t....ptc...p........................lulW.s+ss.....................ps.pt....s.h.....h.pItcph+.chL..ph..p......h...................................................................	0	326	467	676
+3051	PF00932	LTD	IF_C_term; IF_tail;	Lamin Tail Domain	Finn RD, Bateman A, Anantharaman V	anon	Anantharaman V	Domain	The lamin-tail domain (LTD), which has an immunoglobulin (Ig) fold, is found in Nuclear Lamins, Chlo1887 from Chloroflexus, and several bacterial proteins where it occurs with membrane associated  hydrolases of the metallo-beta-lactamase,synaptojanin, and  calcineurin-like phosphoesterase superfamilies [1].	25.70	25.70	25.70	25.80	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.43	0.71	-4.01	51	1619	2009-09-10 16:30:14	2003-04-07 12:59:11	14	164	831	14	675	1585	960	119.30	18	18.47	CHANGED	sssssssssssslhls-hstsusss..........calElhNsus.pslDLsGaplpcp.......ssphthhssshh........sGpslhlhtsss..........tt...thhhttt...ssasst...............s-slsLhsss..Gphlsthshsstss	.......................................hs........stsplhIsE..h.......s.u.....t....................calclh..Nsu....s...psl....sL..u..G....ap..lppp....................sssh..p.hs.sshhhh..................suph.l.slhssss...........................tts.sphhhptp.......hshsss...................................ssth.h.Lhssp......G.p..l.s.ht......t..............................................................................................................	0	248	401	556
+3052	PF00714	IFN-gamma		Interferon gamma	Bateman A	anon	Pfam-B_615 (release 2.1)	Domain	\N	20.30	20.30	20.60	26.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.75	0.71	-4.34	9	229	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	125	13	27	233	0	123.10	50	85.86	CHANGED	lLusSGsYCQusah+ElEsLKpYFNASssDVu-GGsLFLDIL+NWKEESD+KIlQSQIVSFYFKLFEsLKDN.QsIQ+SM-sIKpDhhsKFFNuSpsKhDDFp+LhphsVsDLpVQRKAlsELI+VMs-LSPcSsLRKR	...........................h.c-h-pLKtaF.Nuups...DVucu.GsLFl-ILKNW+...E.-uD.+KIIQSQIVSFYhKlF-.N.h.K..Ds...QhIQ+ShcpIK...EDh...h...s..+....F...h.N.uu.ppKhcDF.p+LhplsVsDLplQRKAlsELhpVhp.cLS..P.tuphtK...........................	2	1	2	7
+3053	PF00047	ig		Immunoglobulin domain	Bateman A, Sonnhammer ELL	anon	Bateman A	Domain	Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases.  Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The Pfam alignments do not include the first and last strand of the immunoglobulin-like domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.98	0.72	-3.85	52	1594	2012-10-03 02:52:13	2003-04-07 12:59:11	20	231	155	48	526	42115	2	63.00	21	11.35	CHANGED	GsssslsCps.....tss.tsphpWhppspthtpttpsth..tt.............................lplsssp.p.cuGsYtChs	..........................................................pslpLsCps...................t.s.....s....t....h.p......W....p......p.......p......s.....p.......s.....h....t......t......t......t....h....t...t....t....p...h....t..t.................................................................................Lh.l.s.s..s......s..............p..cuG.s.YpCh.........................................................................................	1	144	166	265
+3054	PF02395	Peptidase_S6	IGA1; 	Immunoglobulin A1 protease	Bashton M, Bateman A	anon	Pfam-B_540 (release 5.2)	Family	This family consists of immunoglobulin A1 protease proteins.  The immunoglobulin A1 protease cleaves immunoglobulin IgA and is found in pathogenic bacteria such as Neisseria gonorrhoeae [3]. Not all of the members of this family are IgA proteases Swiss:O32555 from E. coli O157:H7 cleaves human coagulation factor V [2] and Swiss:O88093 is a hemoglobin protease from E. coli EB1 [1].	19.70	19.70	19.70	19.70	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	769	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.74	0.70	-13.53	0.70	-6.41	9	1016	2012-10-02 13:45:52	2003-04-07 12:59:11	11	15	370	10	37	880	2	454.70	25	57.43	CHANGED	huhssh..uhAupsp.s.lsYQhaRDFAENKGhFpsGATNIplhsKpGphlG..hhstsPMhDFSsVsss.Gl.....ATLlssQYlVoVpHNu.GhsslsFGs.Gp.................spYphVc+NNhts..................DaphsRLsKaVTEstPsssosshssussYpsppRYsshhRlGuGpQaltp+s.............Gptsphsu.uYpahsuGostt..............uhtNuphhhus.ssstshp.hs........sLsshushGDSGSPLFsYDspcpKWVllGslpshssa.tts.t..slhpppFhsph.pcDpsu.lpt.s...sslshp....ssssGsGslT......pGSp......shchtsppss......................hNtGKsLhFpGt...GslsLpsslsQGAGGLhFcsshphpssss...shTWpGAGIslscGsoVsWpVpsspsDpLpKIGcGTLpVpGsG.NpGuLKsGDGpVILsQQADstsphQAFSpVsIsSGRuTVhLNsspQlsPs.slhaGFR..GG+LDLNGpsLTFc+IpssDpGAhIsNp.os+pSslTlss....ss.IstP............s.s...........h...t.h...hp....pp.phhhLctus.s......s...pss.h.h.G......pppshs+hp.t+htsas..haFstp.ssshsssl.hhhpGps..hhhh.sussNhcGslopppGsLhhoG+Ps.HA....sht.t...........pspslsppDW.NRsF+hcslplcsushhlS..psuslpusIpAo.NuslslG..ssp..hspscuc..TG.hshshctslosscslss.sh..hsGslsLsppus....pthstGltuhsus.plo..spuhashsss	...................................................................................................................................................................................................................................................................................................................................................................................................................t.pa....hp.....t.p...h...t.......................................................s..........................................tt....................t...........h......GDSGSshahast..tpW.h.u......................................................................................................................................................................................................tpsh.h.......t........t..l....h.pth...p.G..u..l.Ft...t...t..h....t...t..h.GuGl.httt..l.Wth........................t....................tD.LtKhG.GsL.lp.h.......t..p.stlphGpG.VlLttp........sFspl.hs.uGpshl.lst....tpth....................t.t........hh.t..GGhL-hsG.s..Fp..l.....s.ts.l.st..............h..............................................................................................................................................................................................................................................................................................p.-W....F.ht..h.h...t..............................................................................................................................................................................................s.................................................................	0	13	18	27
+3055	PF00219	IGFBP		Insulin-like growth factor binding protein	Finn RD	anon	Prosite	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.00	0.72	-3.42	54	1051	2009-09-11 00:39:06	2003-04-07 12:59:11	13	24	116	8	458	832	0	54.50	44	18.34	CHANGED	Cs.....sC..p....C.P..............s.sPsCs.sVp...sGCGCChs..CA+p.......hG-sC......shpshC..spGLpC	......................Cs...sC..p.......C..P...................ss..s.sCs...sVp......-GCGC.Chs..CApp........G-s...C..........s...s.h....s...s....h.C..upGLpC..........	0	48	94	234
+3056	PF01378	IgG_binding_B		B domain	Bateman A	anon	SCOP	Domain	This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.	21.20	21.20	21.20	21.20	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.53	0.72	-4.16	4	50	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	18	74	4	119	0	53.60	73	27.86	CHANGED	TYKLllpGpThpGETTTKAVDAATAEp.sF+QYANsNuVsG-WsYDsATKTFTVTE	.......TYKLVlpGpT..hpGETTTKAVDAATAEK.sFKQYAN-NGV.DG-WoYDDATKTFTVTE...	0	0	0	2
+3057	PF00475	IGPD		Imidazoleglycerol-phosphate dehydratase	Finn RD	anon	Prosite	Family	\N	20.30	20.30	20.60	24.10	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.79	0.71	-4.34	146	3695	2012-10-03 01:04:38	2003-04-07 12:59:11	13	12	3613	24	1011	2611	2275	144.30	51	57.73	CHANGED	TGlsFaDHMLsthu+HuthDLplpupGD...lclDs..HHTVEDsGI..sLGpAlpcALGDKpGIpRa.................GsuhlPMDEuLs............psulDlSGRPalsac..sph.p.tp.lGs....hsoEhlccFFcuhu.sutlTLH.lphhhGc......NsHHhhEAhFKAhu+AL+	.........................................TGVGFaDHMLctlApHGthcLplpscGD..........Lc...ID-.....HHTVE.DsGIsL...Gp.AlppA.LG....D...K.....+...GIpRa.................Gs.hh...lPMDEsLu..........................psslDlS.....GRPaLsac............spas.....p....p+...l.Gs..............hsTEhlccFFculuhsutl.TLH.l.c...sh..Gc......NsHHhlEu..lFKAhuRALR.................	0	330	666	867
+3058	PF00218	IGPS		Indole-3-glycerol phosphate synthase	Finn RD	anon	Prosite	Domain	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.44	0.70	-5.33	20	5164	2012-10-03 05:58:16	2003-04-07 12:59:11	16	18	3907	23	1085	4373	2572	228.50	40	76.40	CHANGED	Lp+Ihsp++tcVsst+pp.s...uclpt.h..t.sssspuFh-sLpp....tpsulIAElK+ASPSKGhIc.-hssschAcsYppuGAusISVLT-scaFpGuh-hLtplRpslslPsLp........KDFllDpYQIhEARhhGADslLLIlusLs-pp..hpcLhphApuLGM-sLVEVpstpElcRAL.tlGA+llGVNNRNL+oFcVDLssTpcLsshls.......t-.slLluESGItotpDlcphpcpGscuhLVGEuLM+ssDhcttl+cL	..........................................................................................................................LtpIhttpt..ltth...p.t...s.....t.h.t.h................................h...s......h..h..tsLpt..................tt...h...shIsEhK+AS...PS..c.....G........l....p...............p.....h....s....s......thAt.....Ypp.h....t........AsslSVLTDpcaFp...............GSh-........Lptl.p.....p.....t.....s.....s......h.....Pl.Lp......................KDF.IIDsaQIh.ARhhGADslLLhl..u..sL...........s...D.........c...p...........hp...cLhshA.c.s.LsM..s.VLlE.VpsppE...l-...R......Al...pL.......s.........s...c..........l....IG...I.N.....N...R....s....L.........+..T..h..p...s.....D........l..s.....p......T....h.....cL...t.....s.....hlP..........................cs...t...lllSESGIhotsplctl.t.th....ssuhLlGpulMpt.ts..ttthtt............................................................................	1	350	707	929
+3059	PF05049	IIGP		Interferon-inducible GTPase (IIGP)	Moxon SJ	anon	Pfam-B_5519 (release 7.7)	Family	Interferon-inducible GTPase (IIGP) is thought to play a role in in intracellular defence. IIGP is predominantly associated with the Golgi apparatus and also localises to the endoplasmic reticulum and exerts a distinct role in IFN-induced intracellular membrane trafficking or processing [1].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.15	0.70	-5.65	6	355	2012-10-05 12:31:08	2003-04-07 12:59:11	8	11	60	8	235	584	54	294.00	31	78.44	CHANGED	SsEllptIcpAlcEGpLpcllShIc-slpslspshlcIAVTG-SGsGhSSFINALRsIGHEE-sSAPTGVVcTThc+TsYpp.s+aPpVhlWDLPGlGuTs.os-oYLEEMpFupYDhFIIIuSppFSpNclcLApsIppMtK+FYhVhTKlDpDLosp......oFsc.clLQsIpcNhpssLQcstVpEPPlFLlSshcsspaDFPcLc-TLhKDLPshKpHshhhoL.sls-psIspKtpsLKp+IhL.EuL+uuhls........tssDhsNhccshKsYRphFGlDDtSLpplApchsh.ltchcsph+u.phashpc--pllcphhphhlptFhtlht......hh.sssshh+chhapphhFL-hVApDAKslLcKI	...................................................ht.thtp.tp....s.h.shlp..p.h..l......t.t..h..p...p......s.......l.pluVsG-oGsGKSShINA.l....R.G....l....s.p.-...-...c..s..u.....A..T..G......V......l.......E....T....T.........h...........c...........s.....s..Y..............a....P..............p.........h...P......s...V..tlW.DL..P.......G.........h................G...........o.........s.....s..........h..............s........c..........p........Y.......L.p..p..h..p..F........tp......Y.....D......h.........F...I..l...l..u...u...p.R..F.p....t.s..-...s.pLA.....ctI......p.....p...h....t...K..p..F...YaV...RoK.............lD....p..D.l...ts..........p.t.....t......p...........p.s.a..s......c.....p....p..h...Lp..p....IR....pp...shp.......pLp......p...t....tl..pps.lFLlSs.h....p....tta.DF..L.psl.p-Lsth+pph.h.....h.slsshs.thlppKtt.hppplhh..uhhssh.t...............c.t.h.t.hp.Yp..FGlDc.Slt.hupphth...tp.hp..hc..............................................................................................................................................................................................................................................................	1	49	83	136
+3060	PF00340	IL1	interleukin-1; 	Interleukin-1 / 18	Finn RD	anon	Prosite	Domain	This family includes interleukin-1 and interleukin-18.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.59	0.71	-4.65	16	589	2012-10-02 19:42:32	2003-04-07 12:59:11	14	3	132	42	189	614	0	110.80	26	54.99	CHANGED	hpspshpppshFsMshhpsp.psstlPVs..LuIcsppL.aLSC.pc.spssLphEts-.P+hhsspcp-hhFhFp+ststspsp...FESutaPsaFluTpp-pp..h.Lsph.ttps.lTDFph	...........................t........t.hh.h.....h.....p.........t..t....t..s...p..t.....h.PVs..L.ul..p...sp...p..h..hLSC...t..p..p..t...s..p.....P.sLpLc..cs....c...h.....c.........h.....s..p...p.cp..s.....t.......h..FhFh.+pp..suspsp....FESutaPuWFluTsp..ps..p........l.lsp..t...t...............t................................	0	9	13	38
+3061	PF00726	IL10		Interleukin 10	Bateman A	anon	Pfam-B_885 (release 2.1)	Domain	\N	24.20	24.20	24.50	24.50	23.80	24.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.00	0.71	-4.96	3	341	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	126	14	83	316	0	146.60	36	93.10	CHANGED	ALLpCLVLLAGVtsSRstYstsESuCTHhPsShPHMLRELRAAFS+VKTFFQpKDQLDNLLLT-SLL-DFKGYLGCQALSEMIQFYLEEVMPQAENHGPEIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKNsFNKLQEKGVYKAMSEFDIFINYIEAYMTI	................................................................................................................................................hs...hLp-LRssFpcl+s.h.hQh..cD.p.hp.s..l..LL..pps.l..l.pphKuhh..G..CpshschlpFYL-c.V.h.Ppu....pp....p....s............s....c..l+..c+lsS...lupphpo.L+h..c.LR..pC...+...p....ahs.C...c...s...+..s...c...u...lp...p...l.+...p...sa.pcL.p.p....p.G.l....hKAhuEhDlhlsalE......................................	0	4	8	25
+3062	PF03039	IL12		Interleukin-12 alpha subunit	Mifsud W	anon	Pfam-B_2071 (release 6.4)	Domain	Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit (e.g. Swiss:P29459) and a 40kDa beta subunit (e.g. Swiss:P29460). It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit.  On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses [1,2].	25.00	25.00	25.60	27.60	23.60	24.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.44	0.70	-5.23	3	97	2012-10-02 01:28:15	2003-04-07 12:59:11	9	3	54	2	30	88	0	172.50	47	88.05	CHANGED	MCP.uRsLLLLATLVLLN...HLSLARsLPsSTsGPuh.t+CLNpSQNLLKTVDssLQsA+EpLEaYSCTAEEIDHEDITKD+TSTVKACLPLELApNESCLAoRETShIT+GSCLTSGKTSaMTTLCLSSIYEDLKMYQlEFQAINAKLLMDPKpQIaLDKuMLsAIDELMQALNaNuETVPQKPS..lsEuDhYRTKhKLCILLHAFRIRAVTINRVMSYLNSS	.....................................................................................lhlshLsLL........Ls.shsLPss...s.....h.sLphSpsLLpsssphL.pKA.+QtLchYsCTsEElDHEDIT+sposTlcACLP.ELhhNEs....C.Lsopch.S...hp...pGpCLsot..+.oSahhsLCLpSI.YEDLKhYpsEFpshstt.LhhpscpQlhL..DpshLssIp-LMQu..LNh.s..u...c..sl.sp.psu........hp.c.c.Y+s+hKLCllL+AFplRsVTIsRhhuYLsu...........	0	1	2	12
+3063	PF02372	IL15		Interleukin 15	Bateman A	anon	Pfam-B_2545 (release 5.4)	Family	Interleukin-15 (IL-15) is a cytokine that possesses a variety of biological functions, including stimulation and maintenance of cellular immune responses [1].	28.50	28.50	28.60	30.10	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.04	0.71	-4.37	14	168	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	53	22	54	152	0	126.90	31	84.55	CHANGED	VhIhuClSAulPpTEAs...Wp........sVIpDLcpIEplhpSlHlDsoLYT.poDs+.pCphpshpCFLLElpVIL+Ep..csssIccplcNllhhusssLso..ptssTtstCK.CEEhEcKNhsEFLQsFs+llQhFlp	...........................................hh.Ch.shh.tTpAp.....hp..............plIpcL..cplcshl..psh.ch-.........hLYT..so.Ds........c....p.CphouhpCFhhEl.Vllc.Es...ssspl..pcplpsllh.hspsL..s..s........t..tp.hs...p.s..sCp.pCEphE.cKshpEFLpphhpllQh...................	0	2	4	16
+3064	PF02394	IL1_propep		Interleukin-1 propeptide	Bateman A	anon	Pfam-B_1500 (release 5.2)	Family	The Interleukin-1 cytokines are translated as precursor proteins.  The N terminal approx. 115 amino acids form a propeptide that is cleaved off to release the active interleukin-1.	21.30	21.30	21.50	22.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.67	0.72	-3.65	23	206	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	87	0	40	195	0	96.10	34	38.57	CHANGED	MApVP-Lhp-hhshYS-.pp-hhaEhDt.shhppsF.DhshssLt....DpslpLphScpphsp..oF+psVsllVAs....-cL+Kh.lshsQsFpDDDLculhsslFEEEsI	.........................MAhVP-h.p-.hsh....hS.......-.pp-.h...t.Dt..p..p.psh.D...hshssh.................cpslpLplScpptsp..oF+.....psVslVVAh....cKL+..+......hshspsFpD-DLpu.l.hsp.lFEEE.l...............	1	2	2	8
+3065	PF00715	IL2		Interleukin 2	Bateman A	anon	Pfam-B_709 (release 2.1)	Domain	\N	25.00	25.00	25.60	25.60	24.60	20.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.02	0.71	-4.47	7	151	2012-10-02 01:28:15	2003-04-07 12:59:11	12	2	76	47	19	164	0	124.30	65	94.53	CHANGED	LSCIALTLsLlsNSAPTSSS..............s+pTQppLEpLLLDLQhLLptlpN.cNsKLoRMLTFKFYhPKp.ATELKHLQCL.EELKPLE-VLsLsQSKNhp.p...hK-hhSNIpVTVLcLKGSETpFpCEYDDETsTlVEFLN+WITFCQSIhS	.......LSCIALoLsLlsNuAP.T.SSS...................TppTppplcpLLLDLQhLLptlpN.cN.KLoRMLTFKFYhPKp.ATELKHLQCL.EELKsLEEVLsLApSKNhphpc.......h+-.hsNIplhVLcLKGSETpFpCEYDD-TsshVEFLN+WITFCQSIhS..	0	1	1	2
+3066	PF02059	IL3		Interleukin-3	Mian N, Bateman A	anon	IPR002183	Family	\N	25.00	25.00	25.80	30.50	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.58	0.71	-4.11	5	41	2012-10-02 01:28:15	2003-04-07 12:59:11	10	1	25	2	11	36	0	113.60	47	79.56	CHANGED	Au.oposol+soRTs.CSslhcEIls+Ls...lssps.ssLNuDDpshLpcsoLRRsNL-sFhppAs-ohssD.osIcSsLKcLpsCLPsATssSspcPIaIKDtDhsDFR+KL+FYLlpL	.........As.sQshsl+Tohsp.CSshlcEIlscLpp.slP..s.ssLNs--psILhcssLRRPNLEAF..pAscohp..Nu.SuIcS....LKpL.PCLPhAT.ssPspcPIpI+DsDasDFR+KLcFYLcsL.	0	1	1	1
+3067	PF00727	IL4		Interleukin 4	Bateman A	anon	Pfam-B_833 (release 2.1)	Domain	\N	20.50	20.50	20.70	20.50	19.50	20.40	hmmbuild  --amino -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.70	0.71	-4.23	8	198	2012-10-02 01:28:15	2003-04-07 12:59:11	13	2	92	24	28	186	0	84.40	48	78.13	CHANGED	pch-hsL+EII+TLN.lTs+.cssChELsVsDVLuAsKNTTEKEhhCRAopVLRphYp+H...............pposlhphLptLDRNLsuLAst.oCoVNEuKpoT..LKDFLERLKoIM+cKYS	......phcIsLpEIIKTLNhLTsc....Ks...sChEL..sV.sDhhsss.K.ssscpEhhC+AuthLpph...p+....................tt..h...h.lttL.psh.uhsth..sCssptsp.......hpphL.tL...............................	0	1	2	3
+3068	PF02025	IL5		Interleukin 5	Bateman A	anon	PSI-BLAST P05113	Domain	\N	21.90	21.90	22.20	25.50	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.47	0.71	-4.05	6	60	2012-10-02 01:28:15	2003-04-07 12:59:11	10	1	46	8	18	50	0	105.40	63	84.89	CHANGED	AlEuPMstLVtETLsLLSTHRTLLIGstsLhIPsPpHKNHQLCIEElFQGIDTLKNQTsQG-AVc+LFpNLSLIKcYIDhQK+KCGtERhRVKQFLDYLQEFLGVINTEWThE	..........................hE.shstLVtETLsLLSoHRTLLIustsLRIPsPsHKNHQLCIEElFQGI-TLKNQTspGssV-+LFQNLSLIKcYI..Dt...Q...K+.KCGtER+RV+QFLDYLQpFLGVhNTEWhhE......	0	1	1	2
+3069	PF00489	IL6	IL-6; 	Interleukin-6/G-CSF/MGF family	Finn RD	anon	Prosite	Domain	\N	21.40	21.40	22.20	21.60	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.86	0.71	-4.63	10	256	2012-10-02 01:28:15	2003-04-07 12:59:11	12	2	99	27	74	227	0	135.50	31	71.80	CHANGED	I++IlucISAL+KE...hCssaphCcssc-sLAENsLsLPKhtppDGCaQoGFNQ-sCLs+IpoGLhEYQsaLphLpsphcusp.sslcsLQhsspsLlphlpQchcs.t..ssssPsspssLtshhpupspah+csshhLIL+sLccFLphSLRAlR	..................................................h.tt............Ctt.t.C.sp..hlhtppL.slPph.p.tDu.C....ppuh..sp..psCLp+lpsG..Lh.aphhL..c..hlps.p.hts..tt....tp..l..csl.phsspsLhphlpp..chc....p......hh.sPs.hp.sshhsphps..ps.tW.+phsh.hlILpsLpsF...LphuhRsl+..........................	0	3	6	22
+3070	PF01415	IL7		Interleukin 7/9 family	Ponting CP, Schultz J, Bork P	anon	SMART	Family	IL-7 is a cytokine that acts as a growth factor for early lymphoid cells of both B- and T-cell lineages. IL-9 is a multi-functional cytokine that, although originally described as a T-cell growth factor, its function in T-cell response remains unclear.	21.00	21.00	21.00	21.30	20.40	20.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.74	0.71	-4.49	7	77	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	28	3	23	73	0	111.60	42	85.17	CHANGED	sltG...+cspshtulL.ls..I-cL.cp..sscssCssN.sshhphpl.sDDspcssF....uc+LpQhhphs.pscFslhhp+VppuspsLhNsTs..................hpppKssppppttNsLsFLKpLLpphppshs+lL+G	................pltGpss.phtu.l.h.ls..IspL.pp..t.tssC..sN..shhph.l.sDsspcshF.....tctLpQhhphs.ptcasLhh.+Vppss.hLhNspst.......................hppppshppppphNshsFLKpLLpphppph.+hhht............	0	2	2	2
+3071	PF00048	IL8	il8; 	Small cytokines (intecrine/chemokine), interleukin-8 like	Eddy SR	anon	Overington enriched	Domain	Includes a number of secreted growth factors and interferons  involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.30	0.72	-4.00	181	2117	2009-01-15 18:05:59	2003-04-07 12:59:11	15	8	161	279	731	2035	0	63.80	25	56.48	CHANGED	hus......C.Chph..psphls.hphl...p.saphhssst.Csp.sulIhp.h+......p.s+plCssP....pppWVpch..l..chL	.........................tt.........C.Chph....tpp.ls...hphl.......p..shp.hhssu...tCsp..tlIhp..hK.................p..scplChsP....ptpaVpchl.pt............................	0	45	90	187
+3072	PF01787	Ilar_coat		Ilarvirus coat protein	Bashton M, Bateman A	anon	Pfam-B_1131 (release 4.2)	Family	This family consists of various coat proteins from the ilarviruses part of the Bromoviridae, members include apple mosaic virus and prune dwarf virus. The ilarvirus coat protein is required to initiate replication of the viral genome in host plants [1].  Members of the Bromoviridae have a positive stand ssRNA genome with no DNA stage in there replication.	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.92	0.71	-4.74	20	499	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	29	2	0	481	0	189.10	34	91.67	CHANGED	s....sstpsststssuRppphsspRAsuhRsp.t....ssstsshPl......slssspps.tsphplphPssts......h..sspssophsupssssh.sshshcThlpsI.pl.cssTKlYsllhGFlu.pSDGhhGhl..-uhsssssssPsslsRhtFKKspYpu+phshssGpsls-l.sshslVWphDss....tpsspplplscaWluhSc.PslhPPpsFLVs--	..........................u..stpsttspssst...htttptsspsss.......tss+hsssh........Pss.spss.popWpl+GPNs.s+.....t.a.sspsp.pElos.s.ssspa.hsIsFpohhtplh...spshplaslllphsu.sSsGhhGhV..-sacss...sssuPNsls...R+...GFpKcp.RGhQacsP....sshshsshscshtlVhcacsp....h.suscV...hhpshal.hSt.s.l..PpshLhsp............	0	0	0	0
+3073	PF01450	IlvC		Acetohydroxy acid isomeroreductase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Prodom_2380 (release 99.1)	Family	Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine.	29.10	29.10	29.10	30.20	28.10	29.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.67	0.71	-4.27	19	5123	2012-10-02 19:36:47	2003-04-07 12:59:11	14	7	3940	36	1202	3289	2644	141.90	39	46.51	CHANGED	Fc-EscoDLFGEQsVLCGGlpt......................LlcsG.......................................................................................................................FETLlEAGYp.PEhAYFEslHE.lKLIVDLIactGlttMphslSsTAEaGshspusRlhsptoKttM+clLc-IQsGsFu+chlhpspsup.p..hpthpcp.cpc.IEplGccLRthhshhp	..........................................................................................................FppEscoDLaGEQs...VL.C.G.ulpu.llpsu..................................FE.sLV.Eu.Gat.PEhAYaEsL..H..E...hcLIs-LlhcGGls.p.Mph.sIS.sTA..Ea.G.sYlhu.sclh..tts+.hh...+....phhs-IQsG...p...Fucs.h..l..t..-..t.......p..s..s.psp.....hps.h.Rc.tttpctIEplGtcLRthMs.h.................................	0	361	757	1011
+3074	PF00920	ILVD_EDD		Dehydratase family	Bateman A	anon	Pfam-B_1309 (release 3.0)	Family	\N	18.60	18.60	18.60	21.70	18.50	18.30	hmmbuild  -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.64	0.70	-6.08	89	6864	2009-09-11 11:08:28	2003-04-07 12:59:11	16	13	3924	2	1852	5418	6322	522.70	40	91.02	CHANGED	+PhIGIssoas...........-hsPsphHLpcluctlKpGlppuGGhP.hpasohulsDGIshGptGMchSLhSR-lIAsslEhhlpups.hDuhlhluuCDKssPGhLMuAsRl.slPulhlsGGshhsGph.....tG...........ppls...hpssa-uhGt.ht....tGclscc-............lpplEpsusPus.GuCushhTANTMsslsEALGhuLPGuushPA......sssc+tphucpuGcplhch..l.....c.c.......slp.Pc-IlTccuhcNAlssshAhGGSTNslLHLhAIA+c...AGlp...lsl.-DF-cluccsPhlsslpPu.G.pah.hpDhptAGGlsslh+pLhct.s..h..LctDshTVo......G+TluEplpps...................................hstc..................................VI+PhssPhps..pG.GltlL+GNLAPcGAVlKhuus........chhta...........cGsAhVF-uE--shpAl.tssclc.Gc........VlVlRapGP+GGPGMsE..MLssTuslh.utGlupcVALlTDGRFSGu.o+GhslGHVuPEAus.GGPIAllcsGDhIpl..Dlt..sppLslh.ls-cE.........l....tp.R.+.......ttat.s.......s......sphp......pG.hLttYsphVssAspGA	................................................+PhIulssoas-hlPu..........H.......hH.Lcc..........hu....chl+culcp.A.Guls.hpF.............s...T.lu................l...sDGIu..h.GptGMhaSLsSR-lIAsSlEhhlsuph.hDuhlhlusCDKlsPGhLMAAhRh.sl...............PslFVsGGPMtsGts..........p.h.............................p.t.ht.....hhshh.c.u.h..t.t.h.s....s.G.c..l..o..c..pc.............l.h..ph..E..ps....uCPos.GoCuGM....aTANoMsslsEuLGl.u.LPGsuol.A....................sp.s..p..Rcplh.tpAGcpllchs........c...c.......................sl.h...Pp...cI......lTccAa-NAhslshAhGGSTNslLHLlAhA...pc.........A...G...l.c......h.sh..cDhsc..lS......cc..VPh..LscltPu....G....p.ah..hpDla....p.A.G...GlsullpcLhc..s..G..........L.L.+t.DshTVs........Gp.TL.s-tlpph............c.........................hs...s.tp.....................................................................lI+s..h-..pP..hpp........cG..GLtl.L.p...........GNLA.p.G.uVlKsuuV.s............ph.h..pa......................pGsAhVF-Sp--.shpAI.....s...s....c..l..p..t..G-.........VVVlRYpGPKG..G..PGM..E..MLtsTu..hLh..utGlGcclA.LlTDGRFSGu.opGhulGHloPEA.A.s.G.....G...............s....IAllc-GDhIplDhs....sppl....pl......l....s..-.tE....................Lsp.R.+.................tt.hp..s..................p............p.ht........pshLttYsphsouAspGA.....................................................................	0	509	1129	1530
+3075	PF05046	Img2		Mitochondrial large subunit ribosomal protein (Img2)	Wood V	anon	Pfam-B_17929 (release 7.6)	Domain	This family of proteins have been identified as part of the mitochondrial large ribosomal subunit in yeast [1].	27.30	27.30	28.30	27.90	26.90	27.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.91	0.72	-3.75	22	279	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	228	0	205	270	3	82.20	32	50.39	CHANGED	shsYaVpR..opsspLPVYhch+ttGs+hhTt.........IRKlpGDl.sLcpDLpphLs...t........shpVs............................chsGplhlKGthhpclccaL.ppsF	.................hsYaVcR......opsp.plPVYhch+.......p.......tGs.+phTh.........lRKl-GDl....htLppDLpphLt...t............tspls..................................phsupltlK.G...h.hpplcpaLhpttF.........................................	0	81	116	170
+3076	PF04156	IncA		IncA protein	Bateman A	anon	Pfam-B_2718 (release 7.3)	Family	Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C. trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions [1]. This family probably includes members of the wider Inc family rather than just IncA.	50.00	50.00	50.20	50.10	49.90	49.90	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.36	0.71	-4.70	54	286	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	42	0	56	201	0	185.00	17	49.97	CHANGED	shptplhslshlllull.llssGlss.Lshhh...hushhsshluhshlAlu..hlLlshulhhhhtpp.ht.hpttp...........................................................chtphppplsplp...cclpp..hppphtphppplpphppshpttp...........p.hpphppclpshppshpphtpchpclh...................t.ht.....htt......t..tthtphhtp.pplhpp...........h	............s.ht.hlhslhhhlhull.llssGlss.Lshhh...husslshhlslshlAls..slllusulhhlhpppphthhpstth...................................................plpphpptlspLp...p-hsp..hppphtphppplpthppsh.ttp...........p.hpshtpplcshppphpphtpchpclh............................tthpphhpphtth..........t.ptlt..htp..t.hp..h........................................................................................................................................	0	5	6	55
+3077	PF02387	IncFII_repA		IncFII RepA protein family	Bateman A, Mian N	anon	Pfam-B_1209 (release 5.2)	Family	This protein is plasmid encoded and found to be essential for plasmid replication [1].	22.90	22.90	22.90	23.10	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.85	0.70	-5.24	22	635	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	342	0	25	477	1	239.80	41	90.66	CHANGED	M...........s+ppYVpNspPhFs.P+psK+pssFI.phhMcpA....uchDlA+p.hphphhshs.hTh..h.................RpRphNtHRApAhcAll.AMhaHashhoshVpsSIcpLuDECGLoThSpuGNpSITRASRhlspFhEshGhIpsc+haD.hlusYIPKhIhlTPhFF.LhslSptpltsApppplpW.Npphpcctht.lohsEhhhpuhc..hpphhphptphh.h.hp+t.A++hhph....sEcsh+pcIlptLl+pYotsELsphG.puLK+cls.cY..L++ltpp.	...........................................................tph..............P.a..stp.t....th....h...thhht+s.....schDhsh..p.....hahp...h....s.........................hR+Rh.sshRpRAlDALl.uLsaahD..shus.....pVptSlopLAhE.CG..Lu..T..cS...u............uG.......p......l......S..I......T..R.Ao..RuL.pal..t..chGl..I...........o....h.pT..p...aD...hush..lPpcIhhTPAhFthL..sVopstltst..p....c..pRlchp.....sppp....pcpth......ss.Lth.D.E......lh....A+s..hR......ahhpRhpshppch+u+.uh+.....R.tR.ARR.sph....pcpchlphltctLp+clstschht.st-slKRpl.hc...........cpphhht.......................................................	0	6	11	18
+3078	PF02974	Inh		Protease inhibitor Inh	Griffiths-Jones SR	anon	Structural domain	Domain	The Inh inhibitor is secreted into the periplasm where its presumed physiological function is to protect periplasmic proteins against the action of secreted proteases [1]. A range of proteases including A, B and C from E. chrysanthemi, alkaline protease from Pseudomonas aeruginosa and the 50 kDa protease from Serratia marcescens are inhibited.	25.00	25.00	25.10	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.29	0.72	-4.42	27	259	2012-10-01 18:54:33	2003-04-07 12:59:11	9	4	230	3	85	217	6	98.80	31	59.58	CHANGED	AoSlhl.ssupluGpWpls...............tsspsCcltLspsph.ts...thuGshsCssph.LuphsssWpsoPcslsLhstsGsslshhs+pscspapuphssG.tslsLpR	..........ssoh...ssusluGpWplu...............tuspsCcltLspsphspG.........hhuGshsCssp...Lsphsu.Wt.s.s.s..ct.lsLh-ssGsslupLhpsupupac..up.ps.uG.pslsLpR....................	0	13	34	54
+3079	PF00876	Innexin	Ogre; 	Innexin	Bateman A	anon	Pfam-B_779 (release 3.0)	Family	This family includes the drosophila proteins Ogre and shaking-B, and the C. elegans proteins Unc-7 and Unc-9. Members of this family are integral membrane proteins which are involved in the formation of gap junctions [1]. This family has been named the Innexins [2].	21.80	21.80	21.90	22.10	21.40	21.70	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.50	0.70	-5.34	99	863	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	123	0	560	840	1	283.30	22	76.49	CHANGED	Dshs.RLpaphTshlLlshul...llos+QY.h....GcP...IpCh...ssphs....ppahssYC..alpsTahl......................................................s...hspph.....................s........sthp.c...thchhsYY...............QW.....VshlLhlQAlhFYlPphlW+.....shpGhplctlspth...................ssshhsp.........-ppcpp...................hchlspah.pptlptpp..th.....................................................shhYhhsclL.llNllsQlahhstF.Lut..............................sat....haGhpllt.h........hps....pphppsh..hFP+lThCsap.....phG.........s.hpp.ass.CVLslNhhNEK.......IalFLWFWhhhlulloshsllahlhplhhs.....phhhphLch.......psphts.....................................................................hpchtt..chLphsshFlLphlspNhssllhp-l...lppLhppapp.p	....................................................................................s.h.+lphhhTshl.......lhhhsh...........llssppa.h...................G.pP......IpCh......s.sphs.............tpahpsYC......WhpsT.ahl................................................................t..pth...........s.......................t.t..........t.htYY...................QW.....lsa...hLhhpAhhhYlPphhW+..........hp.uhp.lphlhpth...........................ppsh..t.................ptpppp........................hphlhphh..p..h.p.pp.h.......................................................................................................................shhYhhhchL.hhs......hlhphhhhsha.ls..t..............................................t.......au....thh.......h...........................h..........hFP+.hsh.Cph......hu..........s..p..hsh.Cll.hNhhsEK..............................lahhla....hWhhhl.hhshh.hh.hhh....h..........hh..hh...........................................................................................................................th.....t.ht.sshhhh..ht.p.s...h.ph...h.th.......t...............................................................................................................................................................................	0	230	281	485
+3080	PF01658	Inos-1-P_synth		Myo-inositol-1-phosphate synthase	Bashton M, Bateman A	anon	Pfam-B_959 (release 4.1)	Family	This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated  to inositol [1]. Inositol phosphates play an important role in  signal transduction.	20.00	20.00	20.00	24.60	19.30	18.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.15	0.71	-4.24	60	1141	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	916	36	533	1086	280	110.30	40	26.16	CHANGED	GtThh+ssLuphhtsRGl+lpshhphNhhGNsDuhsLss.pphcSKchSKosslsshls.......h................................................pts.HhsslcYlPhlGDpKhAasclcsptFhGsshplplphpspDS	............................................GtThh+pVLschhhsRGl+lsphhphNhhGNpDhhNhtp.pphcS.Kc.ISKopsVs..shls....tp..Lh...............................................tpcssHls..s.c.YVPals.DpKhAhschpuchFhG..s..slph+hpspDS.............	1	186	341	459
+3081	PF00459	Inositol_P	inositol_P; 	Inositol monophosphatase family	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.84	0.70	-5.10	59	10135	2012-10-02 15:53:20	2003-04-07 12:59:11	20	42	4250	79	3140	7691	7848	256.80	24	93.87	CHANGED	phpplhphs.......hphsp.tuuplltptht......pphshphcs.........sssD...h..VTtsDptsEphlhpt....lppth....Pscsh..luEE.shstss..........................h........sss.hsWllDPIDGTpsFlcGh..............shaulslulhh......ptpPlhGllhsP.......h................hs...p...hapuhpG........p.Gu..hh...su...............l..plpsss........hspsh..hhsththp.....pttphsp...h..htth.thhstt...............h..R.th...Guush..clshlApGpsD..sahch..s......hp.WDhAAGthllcEAG..............Ghls.chsGs........hsh..hs.t..thlsus...........tth...hhpthp.phht	.........................................................................................................................h........hhphsp.pAuphlh.phhp...........pthphphcp....................................ss.s...........VTp.sDp.ts..cphlhpt.....Lppt...h..............P..s...t..s..l........lu.EE..s..stt.ts..................................................................................tpp.th.hW..llDPlD..GTpsF.lc.sh.............................................sp.a..ulsIAlhp.................cG.....p.....s...h.h....G....l....lasP......h...................................................ts....c.......ha.h...A..t.cG..............t..G...A....h..h....ss...........................p...l...psppsp...................................hp.ts.h....l...h.s.......h..s..h..p...............t..p.t..t...h.t.p............h.....h.t..th..h..t.thptt...................................................h..R..th...G.uu..ul...ch.s.h.V......A......p.........Gp.........h.D....s.a..hch.s........................hp.WD...h...A...AGthl.lpc........AG..................G..hl.s...s.h.pGp.....................sh.h.......tp....t.....thhhss.........................hh..........................................................................................................................................................	0	961	1869	2579
+3082	PF03488	Ins_beta	Ins_beta_nem; 	Nematode insulin-related peptide beta type	Griffiths-Jones SR	anon	PRODOM	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.97	0.72	-4.16	11	116	2012-10-01 19:54:34	2003-04-07 12:59:11	9	2	6	1	114	148	0	47.10	30	45.29	CHANGED	hRuCGR+LhphVhslC.G-.CsspsshDIuspCCpsp..CTc-aI+psCCP	........+tCG.p+lhp...hlhplC..ut.....C.s.....s...psshcl..u.stCCspt....socp.lpptCCP.......	0	32	37	114
+3083	PF03811	Zn_Tnp_IS1	Ins_element1; HTH_Tnp_IS1;	InsA N-terminal domain	Griffiths-Jones SR, Bateman A	anon	PRODOM	Domain	This appears to be a short zinc binding domain found in IS1 InsA family protein. It is found at the N-terminus of the protein and may be a DNA-binding domain.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  --amino -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.90	0.72	-4.46	4	1346	2012-10-03 10:42:43	2003-04-07 12:59:11	8	14	477	0	86	743	12	33.10	58	28.45	CHANGED	MAoVsl+CPpCpus-.VhRHGpussGHpRaRCppC+	........MAolslpCPpC.s...........usc.VVRNGKSTAGH.QRYL.CScCR.....	0	15	37	72
+3084	PF00049	Insulin	ins; 	Insulin/IGF/Relaxin family	Eddy SR	anon	Overington enriched	Domain	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.68	0.72	-3.19	28	1447	2012-10-01 19:54:34	2003-04-07 12:59:11	13	6	340	923	373	1711	0	62.30	31	56.65	CHANGED	ppLCGscLV-sLh.hVC...G-......R.GFaY..P...hsh.......ht....................................................................................h....ptt+......tKRG..IV-pCChpsColtpLpsYC	.......................................................................................plCGtcLscsl..hlC...st...............h...th..................................................................................................................................................................................ppG.....l..scpCC.hp.sCsht..L.t..hC.......................................................................................................................	0	102	130	226
+3085	PF00552	IN_DBD_C	integrase; Integrase;	Integrase DNA binding domain	Bateman A	anon	SCOP	Domain	Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain.  The central domain is the catalytic domain Pfam:PF00665. This domain is the carboxyl terminal domain that is a non-specific DNA binding domain [1].	20.70	20.70	20.70	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.65	0.72	-4.52	37	14492	2009-01-15 18:05:59	2003-04-07 12:59:11	16	61	191	15	23	12714	0	49.90	85	8.72	CHANGED	hppphsYa+...cspstpW+GPsplLhcGcGAlllpspppt.hhhlPc......RcsKhl.s	..........I.QNFRVYYR...DSRDPlWKGPAKLLWKGEGAVVIQ.DNSD..IKVVPR......RKAKIIRD........	0	9	11	16
+3086	PF02920	Integrase_DNA	integrase_DNA; 	DNA binding domain of tn916 integrase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.80	20.80	20.80	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.20	0.72	-4.56	4	459	2012-10-03 08:51:45	2003-04-07 12:59:11	10	6	296	5	41	279	13	64.40	54	14.30	CHANGED	EKc+cs+tchl+suEsptK-hRYhhKYl-phtcspFsYSWKLlsTctssAtKp-sluLR.K.tEIpK	....................EKRRDsKsRlL+sGES..QR.p.DGRYLYKYlDsaGcspaVYSWKLss.TDcsPAGKR-slSLREK.sclp+....................	1	8	15	21
+3087	PF00357	Integrin_alpha	integrin_A; 	Integrin alpha cytoplasmic region	Bateman A, Finn RD	anon	Prosite	Family	This family contains the short intracellular region of integrin alpha chains.	20.20	10.00	20.20	10.10	20.10	9.90	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.96	0.74	-6.32	0.74	-3.75	27	407	2009-01-15 18:05:59	2003-04-07 12:59:11	15	17	77	12	158	412	0	14.90	53	1.49	CHANGED	KhGFFKRph.th.pt	KsGFFKRsh.sh.-.....	0	16	23	59
+3088	PF00362	Integrin_beta	integrin_B; 	Integrin, beta chain	Finn RD	anon	Prosite	Family	Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer [1].  The sequences repeats have been trimmed due to an overlap with EGF.	25.70	25.70	26.20	28.00	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.47	0.70	-5.59	48	945	2009-09-12 08:02:03	2003-04-07 12:59:11	13	57	153	59	425	786	1	347.30	38	48.53	CHANGED	oCp-CIpsuP...pCAWCsp....................................sF.t....sssRCDshp...pL....hppG....CstppIpsPp..uphpl..tcspsLosttt...........................................t.ph.sQlpPQclpLpLRPGp...................................stpFplph+pscsYPVDLYYLMDLShSMcDDLpsl+sLGspLucchp.plTsNaRlGFGSFVDKslhPalsTsPpc.lpsPC....t.t.sCtssFGa+plLoLTccsspFsppVpcQplSGNlDuPEGGFDAlMQsAVC............................pccIGWR..spup+LLVasTDusaHhAGDGK..LuGIlpPNDGpCHLcsss.........hYotSsth....DYPSluQlscKLp-ssIpsIFA......................................VTpphhs.........lY............cpLsphI.s..soslGhLusDSuNVlpLIpcAYpclsScVplp.pshP-s.lslsasupCts.spth.s.....ppCsslplG-p..................VsFsVplsspc.......Cspctt...pshpI+P.....lGFs-p...LpVplphhCc.C	............................................oCtpCl...ts...tCuWCtp.......................................sa............s.R.Cs.....t..pL..h..tpG........C..p.l....P.t..u.p.hph......psps..lspt............................................................................t.sQlpPQpl..tl.....pLR.s...G..p......................................tphplph+....p...sccYPlDLYYLMDLSh.SMpDDLpplcpL....Gs..p.L...hpthp.pl...........T......p....s...hR.lGFGo.FVDKsl.P....ah.pht...Ptc.lpsPC.......t......pC.ssFu....a+plLsLT..s.psppFpptVt.p..p...p.lSu.N....lDsPEGGh.DAlhQssVC........................................................t..pp..IGW..R.....p...sp+LLVFsTDs.shHhA..hD..G+..Lu....GIl.....P.NDGp.CHLpss.................Y.sh.S..p.h..........DYPSluplsppLsp.pNI..IFA........................................V.Tp..p....h.....................................hY.............pphpphl...P......to.s..lG...L...p.p.cS..sN....llp...L...lh.pAYp..plpS.......pV.l.p............p.......scs.....lp...l.pa.p..u.h..C.s....s....h..t......tpCpslplGpp..................lpFplplp..h..p.p.........C...t.p..t......pphhl+s.....hGh.p-t...lpltl..p..h.....CpC..............................................................	0	104	134	265
+3089	PF00143	Interferon	interferon; 	Interferon alpha/beta domain	Sonnhammer ELL	anon	Prosite	Domain	\N	25.00	25.00	25.80	25.10	23.90	23.60	hmmbuild  --amino -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.95	0.71	-4.37	15	1000	2012-10-02 01:28:15	2003-04-07 12:59:11	14	1	135	18	321	1009	0	150.70	39	85.89	CHANGED	LPpsasLss+csLpLLtQMsRlSsh.CLcDRpDFsFPpEhhcupQhQKAQAhsVL+EhLQpIFslFpo-pSS.AuWNpTLL-pLpssLaQQLscLcsCLtppht.pEsshsppssh...Lsl++YFpRIplYLcEKKYSsCAWEVVRsEIhRulShS.sNLptRLRp	................................................ppthhspcsLp..LLs.pMp+.l...s..s..hpC..L.p.-..RpD..F.sFP.p...Ehh.p.u.s...Q.h.Q..K..s.Q.A...l.sl.lHEhlQQhFpLF....s..o.ctSu..AuWspoL...L-phhssLp.QQLpcL-.sClhpphs..pc.s.s..l..hpp.ssh...............Lsl++YF.p+I.s.h.Y.LpEKcYSsCAWElVRsElhRsh.....spL.tthp...............	1	17	20	70
+3090	PF03487	IL13	Interleukin_13; 	Interleukin-13	Griffiths-Jones SR	anon	PRODOM	Family	\N	25.00	25.00	46.40	46.40	23.60	19.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.00	0.72	-4.25	4	47	2012-10-02 01:28:15	2003-04-07 12:59:11	8	1	36	11	14	53	0	42.00	77	32.90	CHANGED	MALhLTsVIALsCLGGLASPuPVPsSs....sLKELIEELVNITQNQ	..MALhLTsVIALTCLGGLASPuPVPs.So....ALKELIEELVNITQNQ.	0	1	1	1
+3091	PF01348	Intron_maturas2		Type II intron maturase	Bateman A	anon	Pfam-B_105 (release 3.0)	Family	Group II introns use intron-encoded reverse transcriptase, maturase and DNA endonuclease activities for site-specific insertion into DNA [2].  Although this type of intron is self splicing in vitro they require a maturase protein for splicing in vivo. It has been shown that a specific region of the aI2 intron is needed for the maturase function [1]. This region was found to be conserved in group II introns and called domain X [3].	20.80	11.50	20.80	12.00	20.70	11.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.98	0.71	-4.23	25	36524	2012-10-02 14:46:49	2003-04-07 12:59:11	16	20	25025	0	102	35521	17	102.30	63	26.36	CHANGED	ppclphhsPlpplltpLscpsahstp........G+PhuhsphssLsDpsIls+aspIhRulhsYYShusN+ppLh.hlpYILRhSCs+TLApKaKs.Tlpphhp+aG................ssLh.pphhsppcph.............shthpphphshpp.......hhschhhlshhp	...........................................h.KKhDTlVPIIPLIGS.L...u.....K.AK..FCNlh..........GHPIS..K..P.l.W.s.D.L.SDS..DII.DRFsRICRNLSHYa.S..G.SS.K.KpsLY...+lKYIl.......................................................................................................................................................................................................................................	1	28	68	90
+3093	PF03519	Invas_SpaK		Invasion protein B family	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	26.90	26.40	24.20	17.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.67	0.72	-4.14	7	181	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	173	8	14	65	0	77.60	50	58.83	CHANGED	GCsssllusLDsHSTIsLcL.p-hPsIpIuhpsDD...lhlWusls-hppshlptpu.plLt.lhpss..sathGt.h.ltcpss	.........GCsPSLIGslDSHSTIsL-L.aulPoIsISlcDDD...VWIWApL....GAsShVlLQQpAYEILhsIME.uC..pFupGsQlLLtcps.......................	0	3	7	9
+3096	PF04741	InvH		InvH outer membrane lipoprotein	Mifsud W	anon	Pfam-B_3503 (release 7.5)	Family	This family represents the Salmonella outer membrane lipoprotein InvH. The molecular function of this protein is unknown, but it is required for the localisation to outer membrane of InvG, which is involved in a type III secretion apparatus mediating host cell invasion [1,2].	25.00	25.00	25.40	25.20	22.80	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.02	0.71	-4.35	3	211	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	181	0	2	80	0	116.60	64	95.63	CHANGED	MKKFYSCLPVFLLIGCAQVPsPSSGSKPVQQP-AQKEQQANAcSIDECMSLPYVPSDLAKNKTLSNQNADNSASKNNTISSSIFCEKYKQTKEQAFTFFQEHPQYMRSKEDEEQLMTEFKKVLLESGSKNLSIYQTLLoAHKRLQAL	...........................MpKhYSCLPhFhLlGCAQss...ShSKPVQQssAQpEQ.AsAsSIDEC.SLPYVPsDLAKNKoLSNpsADNSASKNssISS..SlFsEKY+QTKEQAhsFFQEHPQYMRSKEDEEQLMTEFKKVLLEPGSKNLSIYQTLLsAH-RLQAL.....	0	0	0	1
+3097	PF00904	Involucrin		Involucrin repeat	Bateman A	anon	Pfam-B_1158 (release 3.0)	Repeat	\N	30.00	0.10	30.90	0.30	22.00	-0.10	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.55	0.75	-5.76	0.75	-2.71	129	691	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	12	0	40	721	0	10.00	64	70.08	CHANGED	lEQQEGQLct	.LEQQEGQLch.	0	40	40	40
+3098	PF02121	IP_trans		Phosphatidylinositol transfer protein	Mian N, Bateman A	anon	IPR001666	Family	Along with the structurally unrelated Sec14p family (found in Pfam:PF00650), this family can bind/exchange one molecule of phosphatidylinositol (PI) or phosphatidylcholine (PC) and thus aids their transfer between different membrane compartments. There are three sub-families - all share an N-terminal PITP-like domain, whose sequence is highly conserved. It is described as consisting of three regions. The N-terminal region is thought to bind the lipid and contains two helices and an eight-stranded, mostly antiparallel beta-sheet. An intervening loop region, which is thought to play a role in protein-protein interactions, separates this from the C-terminal region, which exhibits the greatest sequence variation and may be involved in membrane binding. PITP alpha (Swiss:Q00169) has a 16-fold greater affinity for PI than PC. Together with PITP beta (Swiss:P48739), it is expressed ubiquitously in all tissues [1].	21.30	21.30	21.60	22.40	18.60	19.20	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.57	0.70	-5.20	4	692	2012-10-02 19:24:03	2003-04-07 12:59:11	13	19	134	7	422	566	0	221.10	45	46.39	CHANGED	hLIKEYRllLPhSV-EYQVuQLY.lActS+pEouG.GpGVElLhNEPYccs.GtpGQYTHKIYHltS+lPualRhLhPcuALslcEcAWNAYPYsRThhTs.ah.EcF.IcIETaahPDhGpQ-NVapLssssh+ph.lshIDIs.RsQVhsuDYKAEEDPthF+SlKTGRGPLussWtcEh...spstcpP......hMCAYKLspVcF+aWGhQsKlEpFIHc.t.RRlhhphHRQhaCW.DcWh-LTM-DIRchE-ETp+tL	...........................................................................h+Ea.Rl..hP.ho.....V.-E..YpluQLY.lu.ctS+pp............o.........s.........G.............G.pG.....V......E.....llp...N.cPa........p..........c.....s.......................s..............t..............p....GQYTcKlYHlt......S+lPuah+hlh....PcsuLhlcEcAWNAYPYs+..T......h.............h............T.........s......s.ah..-cF.IcIET.hap...s.D..h.G..pp..-N.V......a.sLss.....pp.hpph.pl..shIDIs..pct.l...s.t-YK...t...-..EDPphFp.S........KT.........sRGPL.s..s.Whcph..............pP............................hMCuYKLlplcF+.aWG.h.Q.s+lEpFIp.c..t.........+clhhphHR.....QhasWh.......Dc......W......h.......sLTM-DIRchEccsp..................................................	0	135	169	310
+3099	PF03278	IpaB_EvcA		IpaB/EvcA family	Mifsud W, Bateman A	anon	Pfam-B_4003 (release 6.5)	Family	This family includes IpaB, which is an invasion plasmid antigen from  Shigella [1], as well as EvcA from E. coli Swiss:Q9ZNF1. Members of this family seem to be involved in pathogenicity of some enterobacteria. However the exact function of this component is not clear.	29.90	29.90	35.50	35.00	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.89	0.71	-4.99	9	303	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	125	10	3	134	0	135.40	47	82.57	CHANGED	Muppo.lhlshsKlssplLpsVu+Qo.spDlpsWhppE+psYsSRslNpsIDcaChpNNssIosEs+p+lFphVEpca.plsLDhpuAQSSIsHh....ltuNuhFsKKlDp.C.cGhshts+NsTpsplhNhlucpha-Kphs.....scI-lhp.psp	......................p..hhhshsKhssplLpsVu+Qo...stDhppWhppEphsY.SRslNpp....ID....sYChp..........p...Nu...hI...........SpEp+p+lFphVp.....p.....t......h...p.sLDhp...uAQSSIsHh....l.uNt.FsKKhDt..C...cGhs.....s+tsTpsplhs.lucchap+phs.....s-Ichlp.+sp................	0	0	0	3
+3100	PF04979	IPP-2		Protein phosphatase inhibitor 2 (IPP-2)	Moxon SJ	anon	Pfam-B_5306 (release 7.6)	Family	Protein phosphotase inhibitor 2 (IPP-2) is a phosphoprotein conserved among all eukaryotes, and it appears in both the nucleus and cytoplasm of tissue culture cells[1].	20.90	20.90	20.90	20.90	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.02	0.71	-3.90	20	478	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	281	4	294	440	0	115.20	26	55.30	CHANGED	+KS.pKWDEhNI..LATaHPu-KDYGhMKlDEPpTPYp......pspsshs-s-sscsls....s-sLucKL..sAucupssshthc.-ppssp..p--p-l..o.Eccp++cpFEp+RKhHYsEhhslKLARpLI..scEhps-s---pp	..........................................................+WDEhNl..h.o.c...tp..ct..shMKI-EP..pTPYp.......h...........tsts.......t.....................t......p.........pc.s..pp.th.s..........................sptl.s.pph..........ts.ps...t..p..............p.h..........t.....t...ppppt..........tpppph.......p.pp.p....t+ptpFc.tRKhHY.s.Eh....h.p.........p.ph....tp...........tt.................................................	1	89	146	221
+3101	PF01715	IPPT		IPP transferase	Bashton M, Bateman A	anon	Pfam-B_1875 (release 4.1)	Family	This is a family of IPP transferases EC:2.5.1.8 also known as  tRNA delta(2)-isopentenylpyrophosphate transferase. These enzymes modify both cytoplasmic and mitochondrial tRNAs  at A(37) to give isopentenyl A(37) [2].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.37	12	5290	2012-10-05 12:31:08	2003-04-07 12:59:11	12	20	4605	26	1405	4112	3280	236.80	32	78.09	CHANGED	hplYKshDIGTAKPohp-hpslPH+LlDllDsscsaosupapcpAhptl....p-IptcG+lPllVGGThLYhpuLlcGls.hPts..-sslRtclcpphtppG.shLatpLsphDPttAstIpPsDspRlhRALEVahhTG+shophtpp............tps..ashl.luls.hc+c.LapRIspRhcpMlcsGhlpEV+tLhsps.......hppshsuh+ulGYpphhsaLpG....chs.LsEhhpphhpsTRphAKRQhTWhRp..t.lpWlDst	...............................QlY+s.h.DIGTAKs....o..........c........E...h........t...s.....lP..H+LlD.....lh.......-.s.....s..p................s..........a..Ssu..cFppcAht...tl...............p.c.I...t...s.c.....G...+.l...P.l.l.V.GGTsLYhpuL...l................ps.....h.........s.............h....s.ts............s..........p...l..........R.........t............p............h..........c.....p...................p...........h......t............p............G......................p..t.......L...app....L...t....p...l...D..P....s.A.t....c.I..c...s...s......s.......pRlhRA..L..El...h.h.h.....o...G..p.s..hophhpp......................................t...t....h.......a....p....s...h....h...h.uls....hs..R.phLa.pR...IspRhc.tMl..p.......p...G..h.lc..E....l...ctL.hpps.........................t....s.....h.s..u..h.....pul.GY+phh.s..Yl..pG............................chs....h--......h....h....p...ph....hpsTRphAKRQ...hTWhR.p....t....hpah...t.....................................................................	0	467	901	1191
+3102	PF01745	IPT		Isopentenyl transferase	Bashton M, Bateman A	anon	Pfam-B_2229 (release 4.1)	Family	Isopentenyl transferase / dimethylallyl transferase synthesises isopentenyladensosine 5'-monophosphate, a cytokinin that induces shoot formation on host plants  infected with the Ti plasmid [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.55	0.70	-5.19	7	88	2012-10-05 12:31:08	2003-04-07 12:59:11	11	5	64	7	18	3011	1753	163.70	35	80.48	CHANGED	hplaLIaGsTsTGKTuhultLAppTGhPVlsLDRlQCh.plusGSGRPhssELpuTcRlYLs.sRslscGlIsAccApcpLhtcVppa.s.csulILEGGSISLlppMups.aWpssF.WplpRhcLssc-sFhspAKpRlppMLpspsstsSlLsELsphWtpsst+shLEsIDGYRhhlcaApppplsh-pLhslst..chhppLlpuIApEYhpHAhhQEp-FPth.....thttu.	..........lhlIhGPTsoGKTshAlt..L.....A....c.....t.....h.......u.....h.....s....l..IulDplQ.sh..plssG..Su.R.Pp.s.s.E.L.p.u.s.p......R........aLt....pp.l........p....G......h.ss..t..p..h.....t...h..hh.....l............t....tt.................h......llEGGS....h...SLh.th.........p.................................h.h.....h...........h.....t.....t..a........h.t...Rhtphh.......t..uhhtEl..hh...t.h...httl....sh.......p..h.aht..th..t.........t...................................t...................................................................................................................................	0	5	11	16
+3104	PF00605	IRF		Interferon regulatory factor transcription factor	Bateman A	anon	[1]	Domain	This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.	21.00	21.00	21.10	21.80	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.71	0.72	-4.28	26	872	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	101	29	310	642	0	105.30	43	28.65	CHANGED	RhRL+PWLltplsSGpasGLpWlsp-+phFpIPWKHAuR+shs...-cDusIFKAWAltpG+aptG.-cs.............DPssWKsshRCALNpos-Fp.lhDpop.csspP.aKVYclh...s..t	.........................+h+sWLltQ.lsSspa.PGL.tWls.c.-.+phFpIPWKHAu+pshs...-cDuslFKAWAltp.G.Kapt..G...D.cs...........DPssWKsphRCAL.Np.....s..-Fc.lh.Dpop....c..sspP..aKVYchlst.....................................	0	43	68	158
+3105	PF04120	Iron_permease	iron_permease; 	Low affinity iron permease 	Wood V, Finn RD	anon	Pfam-B_71435 (release 7.3);	Family	\N	25.00	25.00	25.60	25.30	22.40	24.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.54	0.71	-4.57	19	374	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	264	0	195	387	17	117.30	31	64.84	CHANGED	Fs+hAstsuphsGpPhsFllAlhlVllWuloGPlFcaSDTWQLVINTGTTII.TFLMVFLIQNoQNRDss......AlQlKLDELItusptApNsh..........lslEcLsEcELcplcptapchuctsppt.thsttpptpsttstp	................................................Fp+huphhsphsGpshsFlhulhlllsWssoG.P.hapaS-TWQLlINTuTTIl.TFLMVFLlQssQNR...Dst..............AlphKLcELltshp....tApsth..........ls...lEphp.tplpthtt.h.t.t.....................ptt.............................................	0	38	103	150
+3106	PF02060	ISK_Channel		Slow voltage-gated potassium channel	Mian N, Bateman A	anon	IPR000369	Family	\N	20.60	20.60	20.60	20.60	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.79	0.71	-4.56	3	180	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	45	1	100	159	0	96.40	30	75.87	CHANGED	MILPNoTAVhPFLT+LWQETAcQGGNsSG.LARRSPLuDDGKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKDKAYFQARVLESaRuCYVlENQLAVEQPsTHLPELKPSs	.....................................................................................................ttst..p...h.lYlLhVhuhFuhhlluIhLuYh+SK+hE+ps....D.PaplYI.cp-...Wtpt.......................................h..........................	0	4	10	31
+3107	PF00180	Iso_dh	isodh; 	Isocitrate/isopropylmalate dehydrogenase	Finn RD	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.21	0.70	-5.50	23	12354	2012-10-02 21:08:39	2003-04-07 12:59:11	15	30	5707	258	3358	9844	7894	320.30	29	93.82	CHANGED	pIslLPGDGIGPElhpsAl+VLculsppts...hchpacpthlGGsAIDttG..pPLP-ETlcss+cu.-AlLhGAlGGPcW......t.ssphRPEp.GLLsLRKphs.LaANLRPspha..tLtstSPlKp-hscs.lDhllVRELTGGlYFGp.pttps....................st....phuhsTphYocpE.l-RIsRhAFchAtp+.....+t+VsSlDKANVLcsSc....lWRchsp-ltp..............................EaP-lpLpHhllDssuMpLl+sP.ppFD..VllTsNlFGDILSDtAShlsGS.LGhLPSASLus.......pshulaEPlHGSAPDIAGKsh......ANPlAsILSAAMMLRauhshpcpA......stlEsAVppsLpp......GhhTsDLusts........t.huTs-hs-tl	................................................................................................................lshl.GDGIGsE...lh..ts.hc.llcshh..h...................hpl..php......p.h...h.G....t...t...s..h.c...t.p.u...........p.ls..t.....-s.hpshcc.h..ss...sl.........h..Guls.s.Pp...........................s.th+...s....p....l...lt..lRc..........p.h....s.....hasN...l..........RPs......p..ha.............t.s......ssl+..............s.....t.......t...hD.hll.s.REsot.s..Yt..Ghphthss.....................................................................t........tt.suhsh..phh.o.c.pt...hcRls+hA...FchAhp+.....................+.p.......p.ls.hlc.K.uN.lhchsc....sha.+chsp..-.l.uc......................................................................ch..s......c......l..h..hc.chll....Dshsh...ph.l..p.p.P..tpaD..Vlss.Nl...GD.........llSD.....suhh.s......G.u....lG.hhP...uusls.....................pth..uhaE..s.........s...HG.............o...A..P...c..h.....s.Gps..h..........................sNPhu..Ih....ohshh...L.....c......a.............h.......s.......h...t.......p...t.....A..................ptlpp.u...lt.t.s.ltp......t.h.h.Th.Dhtt.h................tspphhp........................................................	1	1065	2017	2773
+3109	PF04279	IspA		Intracellular septation protein A 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	24.00	24.00	24.00	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.17	0.71	-4.30	129	1696	2009-09-11 22:50:41	2003-04-07 12:59:11	10	2	1533	0	344	990	1626	176.80	39	93.65	CHANGED	M.Khll-hhPlllFFlsYp................hts.............................IhhATushlsAollplshhahhtp.+lspMpllohsllllFGuLTlhhpD-pFIKhKPTllYhlFAssLhsuhhh...t+sllcthh..........sptlp.L....scpsWp+LshtWshFFhhhullNhh......................................V........sh....hop-...........hWVsFKlFGhhulsllFhlsQuhhlh+ah.cp	.......................................................MK.hlDalPLllFFsh.YK........................h.h.s.............................IasATushIlATslt.l.h.h.sa.l...p.a.+..Kl-+MtllohllVlVFGGLTLhhHs-pFIKWKsTll..YsLFAssLLlSphh...p..K..sLIp...p...hL..................G.c..pls....L.........P........p...t.......l...W..............s+LN..huWulFFlhhul...h...Nla..........................................l.......ua..h.....h.sps..............hWVs.F.K.lF.GlhulTll.Fsllpulalh+Hh.p.c....................................................	0	85	177	257
+3110	PF01128	IspD	UPF0007;	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	Finn RD, Bateman A, Eberhardt R	anon	Prosite	Family	Members of this family are enzymes which catalyse the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from cytidine triphosphate and 2-C-methyl-D-erythritol 4-phosphate (MEP) [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.35	0.70	-4.83	6	4492	2012-10-03 05:28:31	2003-04-07 12:59:11	14	13	3924	49	957	7221	4670	220.50	32	84.34	CHANGED	lhsllPAAGpGcRMtsGpPKtalsLtGpslLp+TVcuhLup.tlc+IllslsssDhsthppLLss.....plpLVsGGssRs-SVhsGLpAlssss..paVLVHDuARPhltpsslscllAtt-p.psGuIhAlPVpDTIKRs-.sG..hlscT.DRsGLWtAQTPQuFshsLLhcuascu...ppGuphTDDASllEps.GhpVplVsGcssNlKlTpP.DLAlAEhILpp	...................................................sll.AAGhG..p.R.........M.......s............s.................s.........h......P..............KQ...aL...p.l.......s..s........+.....s...ll...h.+...ol.c...s...h..........h....t....p..........s......t.....l.......p..c......l..l....l..s...l...s.....s....s....p...........s....h......h....p....p.....l..h.tp........................ptp.l..p...l...l......p........G.....G....s....p....R.....t.......-......S....V.h...s...u...L..........p..........t.........l.............s........s........p..........t.............s...........h.............V....L.l...H.D.....u.ARPhls...tch...lp.c..........l.l.p.....t....s.......p.........p.............................t..s.....u....s..l.............s........u..l..P............l...t..D.............T.......l....K......p...s......p.............t.s.................hl.......s........p.......T.s.....s........R........s.......p.......L........a......t.......u....Q.......T.....P........Q...........s....F..p...h..p.....h...............Lpc...u...a....p....ps.....................p..p....t....h........p.......h...T...D..-...u...u.....h...........l.E......hh.....G...h....p.......l..t..l..V..p..G..c..h..p..N..l.K....lTpPpDLt.lAchhlt.t..................................................................................................................................................................................	0	339	640	817
+3111	PF01695	IstB_IS21	IstB;	IstB-like ATP binding protein	Bateman A	anon	Pfam-B_982 (release 4.1)	Family	This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences [1].  The function of this protein is unknown, but it may perform a transposase function [2].	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.91	0.71	-4.86	17	7213	2012-10-05 12:31:08	2003-04-07 12:59:11	12	34	2932	5	1265	9058	3056	156.90	22	63.86	CHANGED	p+plpppl+hA+LP.httslEshDasts.ulDcchltpL.tshsalcptpNlllhGPsGsGKTaLAsAlGhpAsc.tGapVhahpsscLlppLptA+t-Gphtptlppls+s.cLLIlD-hGhhPhsppsuphlFcllscRYE+pShllToNhshupWsclhu.DsslAsAlLDRLlHpu.chl	...........................................................................................................................................................................................h...............p......p........t.......p.......s........l..l.h...hG.s.s.GsG....K.o.a.L..A.s.A....l......u..............t................p........h..............h..........p......p..............u....h.......p...........s.......h.....h...h.....p....h......s...............c....l....h...p.........p...........l.......p.......p...........s.......h.......p......p.......s......p.......h...........p.....p.......h......l......p............p.....l......t...p....s....c....l.....L..l.lD...-..l.........G........h.......................h.......s....p................t.........t..........p........h.....l....h......p......l.....l..s...p.....R..h.......p.......p...t.....s.....h.l.....h.T.oN.hs....hp....p......h...t..p..h...hs.......p............................................................................................................	0	465	857	1042
+3112	PF02189	ITAM		Immunoreceptor tyrosine-based activation motif	SMART	anon	Alignment kindly provided by SMART	Motif	\N	21.10	21.10	21.10	21.20	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.63	0.74	-6.93	0.74	-3.24	12	339	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	49	15	123	429	0	21.10	35	14.82	CHANGED	-tlYpsLspcpcsp.YspLspp	..-tlYpsLppspcsp.YssLst...	0	9	10	16
+3113	PF01156	IU_nuc_hydro		Inosine-uridine preferring nucleoside hydrolase	Finn RD, Bateman A	anon	Prosite	Domain	\N	27.80	27.80	27.80	27.90	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.17	0.70	-5.21	118	5444	2009-09-11 13:52:43	2003-04-07 12:59:11	14	17	2525	62	1248	3860	1059	302.10	28	95.00	CHANGED	hpplIlDsD....sG.......h...........DD.AhAlhhuh...t.ps.p...................l...clhulTsl............G..Ns.slcpsspNuhpllphh..............h....ts...lPVht.....Gss.........tP............................t.hhs....tphH....GpsGlss.........................................................................................................h..........sttt...tptp........As............phlhctl.p..ptssc......lsllslGPLTNlAhslptt.Pc.........lhpplcc.....lllMGGuht.................hGN.......................h.ssh...A................EaNha.sDPcAAchVh.s........shs...lshl.sL-..lop....p.....shh.............s.tpthppl....tt.....................ss.shuphltp.hhp.hhhph....................tshshaDslssuhh...h..........Pph...............................................................................................p.spp.hhlsV-ss........s.hshGt............o.ls-.......................t.ssssplsh..plDs.......ptFhphhhp.hlt....ths	.....................................................................................plllDsD..........PG..........h........................D.DAlAlhhAl.....t.pP..c........................................l....-lh...ulos.ss.............G...Ns.....sl.-......p.....s..hpNuhp.l..lphh...........................................t.......pp.........l.P..Vht...Gus...pP..Lh..c.....................................hh.hs........spl.H.....................GpsG.lss..........................................................................................................hs...........................sptth......t.stp......As.......................phlhctl...p......p.s.s...tp..........lTllshGPLTNlAhh.lppp..Pc.................lhpplcc.....lVlMGGuht............................hGN.........................................h..oP..s..A.................EaNla....sD.PEAAph..VFpu..........uhs......................lshs..uL.D...lTp....p.......sh.l.......................................o..sc.h.h.p.phtp...............................................ttt.....su.ph.ltp..lhs...aahphph...........p.t........hsGh.lH.D.sh.s.luhl......l.......p..................P.pl..................h................................................................................p....h..pp..hhlp.V-sp...........u.hstGt...T..lsD....................................t.hsp.sssplhh....sl.Dh...ptFhphhhc.hh...hh.............................................................................................................................................................	0	384	731	1025
+3114	PF04183	IucA_IucC		IucA / IucC family	Bateman A	anon	Pfam-B_1982 (release 7.3)	Family	IucA and IucC catalyse discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate [1]. This family represents the N-terminal region.  The C-terminal region appears to be related to iron transporter proteins.	25.00	25.00	26.30	25.60	24.50	23.80	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.57	0.70	-5.13	168	2438	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	938	17	394	1532	11	241.30	25	40.66	CHANGED	sttsahph....Ep.ulhtGHPhHPssKuR.Gastp-httYuPEhsssh...pLpWlAlccshhphts......................tth...........htpthsspthtt..h.t............................shtsssah.llPlHPWQhppllt...sthts.lspspl.......l.LG...tust.ahsspSlRTlh.....shs....ps.....hhlKhulslp.Tss..hRslssppltsustlsphLpplhtp.-.hh.....pp..shpllpEsAuhshptst..........................th.tctluslhR-sshth..httt.......ppshs..hAuLhpss	...........................................................s.tsaht.EQ..slhpGHPhHPssKu+hGhs.t..p.-.httYuPE..htp.sh...pL.palAlc+shhttps........................tsh....pph.............lpptlssphhpt.htphh.........................................................t.shp...scahhlPVHPWQhcpllt....s.att.lspthl.........l.LG....tstp.ahsspShRTlh.............................sh.s............ps..........halKlslslp.Tus..hRslsspphtsusthschLpplhpp..-.hh.....tp.....thplhtEsuuhshtspp....................................phhppLuslhR-s.hth........tsp......ppshs..hAuLhtp.t.....................................................................	0	100	225	321
+3115	PF01419	Jacalin		Jacalin-like lectin domain	Bateman A	anon	Bateman A	Domain	Proteins containing this domain are lectins.  It is found in 1 to 6 copies in these proteins. The domain is also found in the animal prostatic spermine-binding protein (Swiss:P15501).	21.30	21.30	21.40	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.81	0.71	-4.26	52	1166	2009-01-15 18:05:59	2003-04-07 12:59:11	12	54	224	165	665	1119	2	122.50	23	46.35	CHANGED	Gs.WDDG...sa-uVcKlhVutupsuIs.........hlcF-YsKsst.h.spp+Gtps......htscpFplshs.sEalsuVcGhYcp.........tssllsuLpF+TNKppou.hhG.......sGpcFsLp..pGpKIVGFHGpuu.p...hlpulGsYhss	..........................................................................t.h.hp....hh.h..s.....hlt..........lp.h.pY....p.t...s.......t.........s..ttt...Gstss...............thpp.............hpl.s.hs..sEal.....splpGpast..................................t.shl.puLp.....Fp.....T.....sps......p.....h.....s..s....hhs..........psGs..tF.s..h...ss.........p.s.t.pl.....lGF..a.G+uu..t........hlculGsah.............................	0	227	342	470
+3116	PF02375	JmjN	jmjN; 	jmjN domain	Bateman A	anon	[1]	Family	\N	26.00	26.00	26.40	27.40	25.30	25.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.36	0.72	-4.42	65	1103	2009-01-15 18:05:59	2003-04-07 12:59:11	12	65	271	51	660	1080	7	34.20	45	3.06	CHANGED	PlFcPThEEFpD.hpYlpp..Icp....hut..chGlsKllP	.PlFcPThEEFc.DshtY....Isp..Ics.....ut..+sGIsKllP.....	0	166	312	494
+3117	PF03957	Jun	JNK; 	Jun-like transcription factor	Finn RD	anon	DOMO:DM01956;	Family	\N	20.90	20.90	24.10	22.40	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-12.06	0.70	-4.64	8	302	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	169	1	108	298	0	171.70	38	70.40	CHANGED	METPFYtDDuLSuh....tuuua............s.........u.ss.....shlhK.pohsLNLo-s.uuuLK.Pstt......tstu..ststsuGL.LsSPDlGh.LKLASPELERLIIQS.NGLlTTTPT.PuQFLYPK..........s..lTsEQpsFAEGFVKAL-DLHKQNQ.Lsus..ssuutuASu..hsuP...hus.Au.uslhusuhtsE.PPVYANLSoasPss..s...usuasusohuauA.Ph.........sP.h....ss..PR.......hsALK-EPQTVP-sPS.G-SPP	...............................................................................................................................................................................................................................................ss-.....h.t..hplsos-LE+h..I........l.....s...ss.h.s....oP.s.ss....p....hhhs+....................s..lTcEQEGFA-GFV+ALs-LH..p..pNp...hsss......ss.u..ssss...........h.s......sss...Au.....s...ssh..su..s..hts-..sPV.Yss.....Lssassss......o..........sss.h.s.ss..s.hsas.....................s.h......................ssthP+..................hpuLK.EE.PQTVP-h...st.............................................................................	0	22	33	66
+3118	PF01486	K-box		K-box region	Bashton M, Bateman A	anon	Pfam-B_25 (release 4.0)	Family	The K-box region is commonly found associated with SRF-type transcription factors see Pfam:PF00319. The K-box is a possible coiled-coil structure [2]. Possible role in multimer formation [1].	23.50	23.50	23.50	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.16	0.72	-4.21	68	4553	2009-01-15 18:05:59	2003-04-07 12:59:11	12	15	1081	0	451	4266	0	93.00	28	47.14	CHANGED	asptssss.....htpsphpphppEhsKL+pplctLQ.....ps.RphhGEsLssLshKELppLEppL-pulppIRu+Kscllhsplcphp+KEcplpppNptLppKlt-	.......................................................................ptp..pph...ppE.ht...+L+p.p.cplp.......pp.....R.p.h.h...G..E....-..L..s..s..L.s.h.cELp.pLEppL-p....uLpplRs+K............tp....lh.h.pplpphp+...K.....-.....pp.l.pctNp.Lppph.......................................	0	56	254	350
+3119	PF02960	K1		K1 glycoprotein	Bateman A	anon	Pfam-B_345 (release 6.4)	Family	\N	21.20	21.20	21.50	23.30	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.83	0.71	-4.10	4	847	2012-10-03 02:52:13	2003-04-07 12:59:11	9	4	3	0	0	751	0	99.90	76	46.82	CHANGED	GLSSRLSNRICFWApCANITPETsTVSVSSTTGFK.............h.pTNtLlpIIPATTHAlVVVEEVKSppPaIpV.FLVFMTLVALIGTMCGILGTIIFAHCQKQSDSNKTV.QQLRDYYSLHDFpTEDYTQPVDWY	...GLSSRLSNRICFWApChNITPETaTVSVSSTTGF+TFSTNuLlp..II.ATTHsVVVVcEsKSTNsHIpVPFLVFMTLVALIGTMCGI.L...................................................	0	0	0	0
+3120	PF02149	KA1		Kinase associated domain 1	Mian N, Bateman A	anon	IPR001772	Domain	\N	20.80	20.80	21.10	21.40	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-8.02	0.72	-4.51	26	802	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	272	3	433	777	1	46.20	40	6.17	CHANGED	tsssl+FElplsKl......shhGlch+RluGssahapclssplLppL+L	......s.tshlpaEhEVCKLP.p..........huLsGl+FKRl.u.GsuhsaKslsscIhs-L+L........	0	138	206	321
+3121	PF02524	KID	KID_repeat; 	KID repeat	Bashton M, Bateman A	anon	Pfam-B_1382 (release 5.4)	Repeat	This is family contains the KID repeat as found in Borrelia spirochete RepA / Rep+ proteins.  The function of these proteins is unknown. RepA and related Borrelia proteins have been suggested to play an important genus-wide role in the biology of the Borrelia [1].	20.80	15.10	21.20	15.10	20.10	15.00	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.75	0.77	-5.93	0.77	-2.78	28	617	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	25	0	37	464	0	11.00	84	15.55	CHANGED	KIDsVEpsLpt	KIDsVEKNLpp.	0	37	37	37
+3122	PF00050	Kazal_1	kazal; 	Kazal-type serine protease inhibitor domain	Eddy SR	anon	Prosite	Domain	Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family Swiss:P46721.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.05	0.72	-3.94	51	1792	2012-10-02 00:52:43	2003-04-07 12:59:11	16	207	356	88	938	4387	283	52.00	31	19.67	CHANGED	Csph.............Cs...tphpPVCGoDGhTYsN-Ctl....C.....ppppslplp+pGtC	.......................................................................................Cs.......tp.h.pP...VC....G..o.......D...u....p.....T...Y...sN.c.Cth...................C......................pp....t....t..p...l..p...l..t..p..G.C....................................	0	276	378	621
+3123	PF03522	KCl_Cotrans_1		K-Cl Co-transporter type 1 (KCC1)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	28.00	26.80	24.50	23.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.14	0.72	-4.44	3	128	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	40	0	48	150	0	29.80	66	2.91	CHANGED	VKDRNShLRLTSlGSDEDEETEAusEKVHM	.VKDRpShL.RLpSlhSDE-.-Eo.tsht...-KlpM....	0	2	5	18
+3124	PF03520	KCNQ_channel	KCNQ1_channel; 	KCNQ voltage-gated potassium channel	Griffiths-Jones SR	anon	PRINTS	Family	This family matches to the C-terminal tail of KCNQ type potassium channels.	25.00	25.00	25.20	25.20	24.50	24.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.43	0.71	-5.00	9	568	2009-01-15 18:05:59	2003-04-07 12:59:11	9	14	136	9	208	521	1	163.00	42	29.81	CHANGED	R+Ssusslss....hsuSPoKs.p....ShuFscRo+hh.shh...........ss.usuhD.lt-EcthpC.hphppLpsshKssIRslRhhKaaVAKRKFKEsL+PYDVKDVIEQYSAGHLDhLsRIKpLQtRlDQIlGKsshhsccp.+sK............shtphShhuRVsKVE+QV...tslEpKLDlLlsh...........appphttssssshshsssphP	....................................................................................................p.s......ttSPsKs.K....uh.uhssRsR.h.p.uhthps.t......................ttt.h.s..-...h...-.-..c.sht..s.-...h..hp...-lhs...s...lK.ssIRul.R..hh+FhVuKRKFKEs...LRPYDV+DVIEQYSAGHLDMLsRIKpLQs.R.............lDQIlG+s......ss+.c.+.p.K.........................................c.p.ShhuRlsKVE+.QV...tsh-pKLD..hLlsh............h.phht..s........................................................	0	34	52	115
+3125	PF03812	KdgT		2-keto-3-deoxygluconate permease	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	25.30	25.10	19.80	22.00	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.09	0.70	-5.27	3	900	2012-10-02 17:06:44	2003-04-07 12:59:11	8	5	674	0	114	494	12	292.30	53	95.17	CHANGED	MKIKpoIEKIPGGMMLVPLFLGALCNTFoPGAGKYFGSFTNGLITGTlPILAVWFFCMGASI-F+ATGTlLRKSGTLVVTKIAsAWVVAlIAupFIP-DGIQsGFFAGLSVLALVAAMDMTNGGLYAALMNQYGoKEEAGAFVLMSLESGPLMTMVILGsoGIAoFEPclFVGAVLPFLlGFALGNLDPDLR-LFSKuVQTLIPFFAFALGNTINLoVIlQTGLLGIFLGVuVIIVTGIPLILADKFIGGGDGTAGVAASSSAGAAVATPlLIAEMsPuFAPVApuATALVATSVIVTSlLVPIlTulWuKKlK	....................MpIK+slE+lPGGMMlVPLhlGALhpTFuPtA...hc......hG..uFTs.uh.h..s..G..s..s..P.IL.ulahhCMGAsIplpAs.spsL+.KuG.oLs.loKlulAhlluhlsu+lhstcG.l......hGLSsLAllAAMs.oNGGLYAulhtpYGsc...............c-u...GAhslhSLpsGPhhTMl...hL...GsA.GlA..s..h..hshVusllPhllGhhLGNLDs-hR-Fhscus.sLIPFFAFALGssIsLshlhp.sGLhGIL.LGlhslhlsGh..h.IhAD+.L...l....u...G.....G.s..G.sA..Gh..AA..SSoAGsAVATPshIAphsP.u.F.p..s.hAsuAT..ulVAsuVIlTuILsPlLTuhhu++................	0	29	52	90
+3126	PF03814	KdpA		Potassium-transporting ATPase A subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.30	20.30	22.30	22.20	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.82	0.70	-6.50	14	2239	2012-10-03 11:11:44	2003-04-07 12:59:11	10	6	1897	0	441	1655	66	488.70	47	98.06	CHANGED	IhlhlsllsslshsLGtYlt+Vatsp+.............shhs.lhsslEphlY+lhGlsPcp-MsW+pYhhAlLshNlhhhlllahllhhQusLPhNPsshsuhs.cLAFNTAlSFlTNTNhQsYuGEsohSYhSQMhulTh..FsSAATGlAVuhAhlRGlstppsstLGNFasDLlRshhRlLLPluhllAllLlhtGlPQTLtu..hsssTLpGuhQpIshGPVAS.EAIK.LGTNGGGFFsANSAHPFENPsshoNhlchluhhllPsAhhasFGchltsp.....+QuhslhsshhllaluhsslshhuEhtGN..PhlpsLGlp........suNMEGKEsRFGhutSuLaAlsTTusosGuVNuMHDShTPlGGhlsLhtMhLspl.hGGhGsGlhshlhallLsVFluGLMVGRTPEaLGKKIEu+ElKhssLslLlpPlhlLl.oAlAhslPsuhuuhsNPG.HGhSElLYtaoSAuANNGSuFuGLssNT.aaNlohGlsMLlGRalsIlshLAIAGSLAsKpssPtosGTlsTDssLFsuLLlusllIlGuLTFhPsLALGPIu...EtLs	...................................................................hhhlhllhlluhPLGtalt+.lhpsp...................h...h.h.s.lEphla....+lhGlp....s....t....tcMsW+pYhhulLshNhhshhhlahlhhhQthLPL.N.Ppt................h.s.u.h.s...cLAhNTAlSFlTNTNhQtYoGE..sslSYhoQMhGlsh.pFlSAAoGlAVhhAllRu.h..............s...................t.......p.............p................h........p.......................s...................lGNaWsDlsRhslhlLlPluhllAlhhltQGs.Qshp..................s.h.t.................l.......p.........T.....l............p.................G............s..........p...Q.........h.....l.....shGPVAS.EAIK.LGTNGGGFFsuNSuHPFENPoshoNhlphhulhLIPsALsasFGchstcc.............................RQ....GhhlhhuMhhlFlhsls.lsh.huE.hpGN..Phl.t.sh.G.htt.............................usNM.EGKEsRFGlh.............h..............SuLFu.ssTTusSsGuVNuMHDShTsLGGhlshh.M.lspV.FGGVGsGLhshllaslLuVFIuGLMlGRTPEYLGKKI-s+EMKhs.sLslLlpP.hllLhhoAlA....h.........h....h......s..........u.......u........t...s.....u............h............hN........P.....G...............HGhSElLYthoSAAsNNGSuFuGL.s......s........N......T................s................F.............aNhhhuhsMhlGRFhsIlshlAlAGSL..........ssK.....+..h........s.t.o..s..GTlsTcsshFsslLlsslllluALTFhPsLuLGPlAEaL............................	0	126	260	357
+3127	PF02669	KdpC		K+-transporting ATPase, c chain	Bashton M, Bateman A	anon	COG2156	Family	This family consists of K+-transporting ATPase, c chain, KdpC. KdpC forms strong interactions with the KdpA subunit, serving to assemble and stabilise the Kdp complex [1].  It has been suggested that KdpC could be one of the connecting links between the energy providing subunit KdpB and the K+-transporting subunit KdpA [1].  The K+ transport system actively transports K+ ions via ATP hydrolysis.	19.90	19.90	20.10	20.10	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.13	0.71	-4.60	3	2067	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	1913	0	393	1342	41	180.70	42	95.45	CHANGED	hRsLlPALoohllLhlITGlVYPLlVTVlGQLaFPaQANGSLIc-u.GQVlGSALIGQsFTusGYFHuRPSAsu-u.....YssuASGGSNLAPSNP-LLutIAARVsAhRtEN..sAuspVPVDLVTuSGSGLDPsISPsAAphQhPRVAKARNISlcQLppLIsKHT-uRhLGalGEPuVNVLcLNLALD+L	.......................................h...lpsulthhlhh....hl.l.s....Ghl..YPLlhTuluQ.h.h.FstQ.ANGS..Ll.p......ps.....s.......p..............l..l..GStLIG.....Qs.....F.........T...............s......s.......t.........YFaGR.....P.....S.....A.ss.t.................Ysst.......u...S.GGS.Nhus.......o.......N.............P..............cLtpplp........t.+.......l.s...t.h.............pt.......tN............s.s.....s.....s.....V.....P..sDL.VTuSuSGLDPcIoPpuAthQlsRVAc..A......R........s..........l.sh...pp...lppL...l...scpopt..h.huh...lG.ps.hVNVLcLNlALDp...............................................................	1	117	235	323
+3128	PF02702	KdpD		Osmosensitive K+ channel His kinase sensor domain	Bashton M, Bateman A	anon	COGs	Family	This is a family of KdpD sensor kinase proteins that regulate the kdpFABC operon responsible for potassium transport [1].  The aligned region corresponds to the N-terminal cytoplasmic part of the protein which may be  the sensor domain responsible for sensing turgor pressure [2].	26.10	26.10	26.20	28.40	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.12	0.70	-5.20	21	2010	2009-09-10 15:55:13	2003-04-07 12:59:11	12	29	1860	2	394	1489	34	208.40	55	27.21	CHANGED	scRG+L+IalGhAsGVGKTYsMLp-A+chhcpGhDVVlGhVETHGRs-TtshlcGLthlPh+plpY+GhtLpEhDlDAlL.tR+PpllLVDELAHTNssGSR+cKRaQDlEELLsAGIDVaTTlNlQHlESLNDlVppITGlpVRETVPDpllcpAD-lhllDlsP--LhcRLppGKlYts-pscpAlsNFFphsNLsALRELALRcsADcV	.......pRG+LKlahGAusGVGKTaAMLscApcht.tpGlDlVl.GlVETHGRt-..TsAhl..-G...LthlPh+pl...pY+...G+plpEhDLDAsL....tR.........+.........P.s.llLlDELAHo.....Ns.....PG...S......R...H............KRWQDlEELLcAGIDVaTTVNlQHLESLNDlVp..tlTGlpV+..ET.VPD.hhcp.AD-l.LVDlsP--LhpRLpcGKVYhs.c........p.s.-pA.l.......psFFphuNLhALRELALRcsAD+V..............	0	120	245	325
+3129	PF04962	KduI		KduI/IolB family	Bateman A	anon	COG3717 & Pfam-B_11840 (release 10.0)	Domain	This family includes the 5-keto 4-deoxyuronate isomerase enzyme EC:5.3.1.17 that is involved in pectin degradation. This family aldo includes bacterial Myo-inositol catabolism (IolB) proteins. The Bacillus subtilis inositol operon (iolABCDEFGHIJ) is involved in myo-inositol catabolism. Glucose repression of the iol operon induced by inositol is exerted through catabolite repression mediated by CcpA and the iol induction system mediated by IolR [2]. The exact function of IolB is unknown. Members of this family possess a Cupin like structure.	20.10	20.10	20.10	20.60	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.73	0.70	-5.31	72	2006	2012-10-10 13:59:34	2003-04-07 12:59:11	7	5	1578	16	396	1311	510	252.20	30	91.15	CHANGED	LLs+s.t...psGp...lhploPcsA.....sWpalGFplhcLtsGpshphp.....ssspEhslVll...sGpssVss....ts...patplGsR.toVF-.......tsPtulYlPsspphplsA.tss...sclAl.ssAPupssh..ss+.hlsPsslshptRGpGssp....RhVpsIhspsps....AcsLLVsEVh.TPuGsWSSYPPHKHDp-s.s....tEohLEEsYYa+lsPsp..........GFuhQRVYo....-.....DcslD-shsVpstDVVhVP+GYH.PsssssGY-hY.YLNVMAGPp..RtWthps-PsHpWl	................................................................hh.hhh..........t.....hhph.sp.h.....shthh.s.h.p...h...h.h.h..t.sGcshp.h.......hpcRElsllsl.......uGsuslps.........-G...p.hhclGpR................-ulYls....pus.c.........s....lhu....tss.........A+...hh.l.ssAPA....+..p.sa......Ps..+.....hl.s.......ss...........-............s....s........s..................p.....hG..c..s...tss..............Rplpphh.....ss......s.......sh......tsspL.hu.sh.sPGuhWsohPsHpH-cc..s......t.p..ppsa.aat.hpPpp..................hh..................t...sc..ph..s..lpNcp.sVls.P.ph.....sltuusGhcsY.alhsMsG.s...........p.h...hsD..cH.h..................	0	122	254	318
+3130	PF02422	Keratin		Keratin	Bateman A	anon	Pfam-B_1920 (release 5.4)	Family	This family represents avian keratin proteins [1], found in feathers, scale and claw.	25.00	25.00	25.10	25.10	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.58	0.72	-4.03	4	299	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	20	0	238	304	0	100.70	56	90.20	CHANGED	SChs..L.CtP..Cs...PTPLAsSCNEPCVRQC.DSoVVIQPssVVVThPGPILSSFPQsosVG.SouA.AV..GShLutp.GhshuSGGa.GLuGaGGpYsG.hst.s	.......................................SC.s........CtP...Cs....PsPLAsS.CNEPCV.RQCQDSpVVIQPsPVVVTLPGPILSSFPQNTuVG.uST.SA...AV......GSh...L..Ssp....Gl........P..I.o..SG....G.F.....sl...u..shus..t.hs.G.hs.............................................................................	0	0	0	98
+3131	PF01500	Keratin_B2		Keratin, high sulfur B2 protein	Bateman A	anon	Pfam-B_706 (release 4.0)	Family	High sulfur proteins are cysteine-rich proteins synthesised during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments [1]. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat [1]. This family is also known as B2 or KAP1.	27.60	27.60	28.00	27.60	27.40	27.50	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.61	0.71	-12.53	0.71	-4.47	8	307	2012-10-03 03:07:01	2003-04-07 12:59:11	12	11	41	0	85	433	0	97.90	45	90.76	CHANGED	M..ACCuTSFCGFPoCSTuGTCGushCQPsC.p....................................oSCCQPoCspTSCCQPhs..oSCCpPo......................CpP.shQTSCCQPTChQTSuCpTGCGIGGuhGYGQ.GSSGAVSoRhRWCRPDCRVEGTCLPPCCVVSCTsPoCCQLaaAQASCCRPSYCGQSCCRPsC.......CC.............CsEPoC	............sCt......s.hSo.u.CG........p..............soCCpsssspTosCp.P................................CppP.sC.hpsssht..p.us...................................................................................................................................	0	17	17	18
+3132	PF04579	Keratin_matx		Keratin, high-sulphur matrix protein	Waterfield DI, Finn RD	anon	Pfam-B_4676 (release 7.5)	Family	Family of Keratin, high-sulfur matrix proteins.  The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulphur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas microfibrils contain the larger, low-sulphur keratins (40-56 kDa) [1].	25.00	25.00	32.40	94.70	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.43	0.72	-10.87	0.72	-3.71	4	69	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	27	0	36	73	0	96.40	74	96.39	CHANGED	ACCAhhCCSVPTGPATTICSSDK.CRCGVCLPSTCPHsI.LLQPTCC.DNsPPPCphPpshVPTCFLLNSsHPTPGLpuINLTTYlQPGCEpPC.PRC	..........CCss+...sCSVPTGPATTICSSDKsCRCGVCLPSTCPHpl.LLpPTCC.DsCPPPCplPp.....shVPTCaLLNSspPTPGLpsINLTTasQP.sCE.....PC.PpC.....	0	3	3	5
+3133	PF03882	KicB		KicB killing factor	Bateman A	anon	COG3006	Family	The kicA and kicB genes are found upstream of mukB. It has been suggested that the kicB gene encodes a killing factor and the kicA gene codes for a protein that suppresses the killing function of the kicB gene product [1]. It was also demonstrated that KicA and KicB can function as a post-segregational killing system, when the genes are transferred from the E. coli chromosome onto a plasmid [1].	20.00	20.00	20.30	21.20	18.00	19.90	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.54	0.70	-5.86	3	769	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	745	10	73	342	4	428.70	78	99.75	CHANGED	MSEFSQT.....IPELVoWAKcpDFSLNLPTERLuFLLAIAlLNNERLDGEMuEGELVDAFRHVocAFEQSoEAIAsRANNAINDLVKQRLLNRFTSEhTEGsAIYRLTPLGIGITDYYIRQREFSsLRLSlQLSIVADElpRAuDSAEEGG-....EaHWRRNVFAPLKYSVAEIFDSIDLoQRlMDEQQQSVKD-IA-LLNKDWRAAISSCEtLLSETSGTLRELQDTLpAAGDKLQAQLLRIQDCVhG+DDLaFIDcLloDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFSQRLRQSlpcYFDcPWaLTYAsAERLlDLRDEEMsLRDEEVTGELPEELEYEELs-l+DQLAp+Ip-hLtVYKEpssPIDLuLVLREYLusYPRoRHFDVARIVVDQAVRLGhApuDaoGI.PDWQAINDaGAKVQAHVIDKY	......................................................MSEFSQT.....VPELVAWARKNDFSISLPsDRLuFLLAlATLNGERLDGEMSEGELVDAFRHVS-AFEQTSETIuVRANNAINDMVRQRLLNRFTSE.AEGNAIYRLTPLGIGITDYYIRQREFSTL.RLSMQLSIVAuELKR.AADAAEEG.GD....EFHWHRNVYAPLKYSVAEIFDSIDLTQRlMDEQQQQVKDDIApLLNKDWRAAISSCElLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMs.+.D.DL.aFVD+LVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDK.N.RVFAQRLRQSVQsYFDcPWALTYANADRLLDMRDEEM.uLRDEEVTGELP.DLEYEEF.NEIR.E.QLAAlIE-pLAlYKs+QsPLDLGLVlREYLuQYPR..ARHFDVARIVlDQAVRLGVApADFo.GL.PAcWQsINDYGAKVQAHVIDKY..................................................................................	0	8	23	49
+3134	PF04383	KilA-N		KilA-N domain	Aravind L, Iyer LM, Bateman A	anon	Iyer LM	Domain	The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease [1].	21.00	19.70	21.00	19.70	20.90	19.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.46	0.72	-4.44	139	2605	2009-01-15 18:05:59	2003-04-07 12:59:11	8	39	812	3	1531	2312	29	103.00	27	37.07	CHANGED	hphsphplll.pp.p.ss...alNhTcltchs.....t...Kc......hppWh+pcpopcllpphppt.s...........................................h...............................h...tttpttp.........hp.G...sY.lH.clshplA.pW.ISs.paslhl.chlpphhpt	.................................................h.l..cp.p..ss...hhphpslhpst......t.pp.+p.................pcWhcsppTpEllpphppth.ht.......................................................................................................................h.h.s.ptthsst.........hp.G...hY.lHc.Ll.shA.hW..hSP.cathhlhchhDplpp..................................................................	2	1330	1420	1504
+3135	PF02172	KIX		KIX domain	Bateman A	anon	Pfam-B_4149 (Release 4.2)	Domain	CBP and P300 bind to the CREB via a domain known as KIX [1]. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.	21.20	21.20	23.40	23.10	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.58	0.72	-3.93	6	242	2009-09-11 11:24:58	2003-04-07 12:59:11	11	28	90	6	142	201	0	78.30	70	4.11	CHANGED	shcKsW+cplTpDLRsHLVcKLVpAIFPsPDssAhpDpRMcsLluYA+KVEt-MaEpApsR-EYYHLLAEKIYKIQKELcE	............G.h+KsWHEclTQDLRNHLVHK....L........VQAIF.PT...P..DPAAL.K..D+RMENL..VAYARKVEGDMYEoANoR....sEYYHLLAEKIYKI.QKELEE..........	1	45	57	101
+3136	PF03037	KMP11		Kinetoplastid membrane protein 11	Griffiths-Jones SR	anon	Pfam-B_1062 (release 6.4)	Family	Kinetoplastid membrane protein 11 is a major cell surface glycoprotein  of the parasite Leishmania donovani.	25.40	25.40	25.40	139.80	24.70	25.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.14	0.72	-3.40	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	19	0	4	44	0	88.60	90	97.89	CHANGED	MATTYEEFuAKLDRLDsEFsKKMpEQNtKFFADKPDESTLSPEMKEHYEKFEKMIQEHTDKFNKKM+EHSEHFKtKFAELLEQQKNAQaP	MATTYEEFuAKLDRLD-EFNKKMQEQNAKFFADKPDESTLSPEMKEHYEKFERMI+EHT-KFNKKMHEHSEHFKpKFAELLEQQKAAQaP..	0	1	2	4
+3137	PF03790	KNOX1		KNOX1 domain 	Finn RD	anon	Pfam-B_533 (release 7.0)	Family	The MEINOX region is comprised of two domains, KNOX1 and KNOX2.  KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerisation [1]. 	20.50	20.50	20.80	20.60	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.17	0.72	-4.63	30	1800	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	158	0	141	642	2	43.00	58	16.60	CHANGED	sslKAKIhuHPpYspLLsAYlsCpKVGAPPElsshL-tlppctcs	......ulKuKIluHPpYPpLLuAYlDCQK.....lGAPPE.VVucLDtlopEhp....................	0	14	85	119
+3138	PF03791	KNOX2		KNOX2 domain 	Finn RD	anon	Pfam-B_533 (release 7.0)	Family	The MEINOX region is comprised of two domains, KNOX1 and KNOX2.  KNOX1 plays a role in suppressing target gene expression. KNOX2, essential for function, is thought to be necessary for homo-dimerisation [1]. 	20.80	20.80	21.00	21.10	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.67	0.72	-4.69	20	1804	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	164	0	135	669	0	34.80	65	13.37	CHANGED	sssslGsDPELDpFMEsYCclLsKY+-ELo+Pac....EAhsFLpcIEsQLssLst	......th...sIGhDPE.LDQFM..EAYC...EMLhKY+ppL..............................	1	13	84	115
+3139	PF00051	Kringle	kringle; 	Kringle domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.	26.30	26.30	26.70	26.30	25.60	26.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.28	0.72	-3.88	24	2697	2009-01-15 18:05:59	2003-04-07 12:59:11	13	237	179	118	1376	2545	55	76.90	39	21.44	CHANGED	ChpGsGpsYRGshupTtSGhsCQtWsuphs+phsh.sspp.sstsLtt...NYCRNPDG-tc.PWCYT.pssphpaEaC.slspC	......................................................Ch.p.s.s.G..psYRGsh.s..h....T....t...oG....h.....p..CQtW.s..u....p.h..P..H....p.......a......p...h........p....s...p..p...h..s..........s..tsL.pc.................NY..C............R....N....P.....D....u.......c........t....p....P..WCYT....s.....s...s...p......h......p....a...-a.C.slstC.....................................	0	528	604	870
+3140	PF00197	Kunitz_legume		Trypsin and protease inhibitor	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	21.30	21.10	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.58	0.71	-4.72	17	766	2012-10-02 19:42:32	2003-04-07 12:59:11	13	4	124	55	109	793	0	164.40	31	83.53	CHANGED	sVlDs-Gc.lpsGGsYYllsthhutGGG....hphstsup..CPLsVVposs-ls...pGhPlphss.h..tssh.ssh...ohlplpFsshs.phsss.....hWpVscpptt.t..hVphuthcs...sp..s.hFKlc+sst.........YKLlaCstt...........ptCpslGlphD.tcshpRLllopp.sPlslhFpK	........................VlDspGct.lp..s.G..s.pYh.Ihs..shhs..t..uGs..........lth.s.s..ss..t.hC.P....s..Vlppst...p..s...pGh.P..VpFos......hpspsslIp.so.lslp.F.s..ss..o.s...ph.sss..............hW+.ltpp.............s...........s..s...........t.....sh...hVsTGGstu..............tshFKIpKhss...s.............YpLs.aCP.s...........ps.C.hslGhh.hp.....t.phLs.hsp....sh.hhF......................................	0	7	91	97
+3142	PF02442	L1R_F9L	L1L_F9_C19; 	Lipid membrane protein of large eukaryotic DNA viruses	Mian N, Bateman A, Coggill P	anon	Pfam-B_1868 (release 5.4), Iyer L	Family	The four families of large eukaryotic DNA viruses, Poxviridae, Asfarviridae, Iridoviridae, and Phycodnaviridae, referred to collectively as nucleocytoplasmic large DNA viruses or NCLDV, have all been shown to have a lipid membrane, in spite of the major differences in virion structure. The paralogous genes L1R and F9L encode membrane proteins that have a conserved domain architecture, with a single, C-terminal transmembrane helix, and an N-terminal, multiple-disulfide-bonded domain. The conservation of the myristoylated, disulfide-bonded protein L1R/F9L in most of the NCLDV correlates with the conservation of the thiol-disulfide oxidoreductase E10R which, in vaccinia virus, is required for the formation of disulfide bonds in L1R and F9L [2].	21.90	21.90	22.80	65.90	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.42	0.71	-4.84	32	163	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	82	6	0	124	2	198.30	32	74.57	CHANGED	Musus..slp........slhsthsp+hhppLspp.sssssssC..slcIGplpsch.psCslpltNhC.sssphp...hshllpuhp-.shssLspcp+ttl............Atplshsl.ssssp..hpsplcppC.pupuslsspIsl...pslplspC.usssph.hphphlNoGoutuNCuhpulhsshsppss.....stltpp.pstspsh...hhlhhsllllhlhhlhhh	...........Musst..shp........ThhNhh.-+hhpcLtQp.sssssssC..sIcIGplhhch.+sCslplpNhC.usushp...hshllpuhpE.shssLspcp+shl............AtpIthsl.ssssp...h.splcpsC.supAslsNhlcI...Qsl.ls-CtussGph.hplphlNoGoupuNCulpslhpshsKtss.......Itpp.phshtsh...hhllhlllllllhslhhh......	0	0	0	0
+3143	PF05047	L51_S25_CI-B8		Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain 	Wood V, Bateman A, Finn RD	anon	Pfam-B_9461 (release 7.6)	Domain	The proteins in this family are located in the  mitochondrion. The family includes ribosomal protein L51, and S25. This family also includes mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) EC:1.6.5.3. It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins.	21.00	21.00	21.20	21.20	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.29	0.72	-4.23	67	788	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	307	1	534	748	8	54.90	25	38.29	CHANGED	sRpFl.ppphsshp.tpNPpl.lhlpc...pss.p....PhlhucYtsG.............................pccplslcshss	............sRpFl.cpplsp....h....p.ppNPpl.lhlpc.....psshp........PtlhucY.t.pG........................................ppctlslcshp................................................................................	0	164	279	432
+3144	PF04604	L_biotic_typeA		Type-A lantibiotic	Waterfield DI, Finn RD	anon	Pfam-B_4608 (release 7.5)	Family	Lantibiotics are antibiotic peptides distinguished by the presence of the rare thioether amino acids lanthionine and/or methyl-lanthionine. They are produced by Gram-positive bacteria as gene-encoded precursor peptides and undergo post-translational modification to generate the mature peptide. Based on their structural and functional features lantibiotics are currently divided into two major groups: the flexible amphiphilic type-A and the rather rigid and globular type-B. Type-A lantibiotics act primarily by pore formation in the bacterial membrane by a mechanism involving the interaction with specific docking molecules such as the membrane precursor lipid II [1].	21.70	21.70	22.00	21.80	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.52	0.72	-4.32	15	102	2012-10-02 23:56:30	2003-04-07 12:59:11	8	1	70	0	6	64	0	48.00	40	91.69	CHANGED	Mcppp.......-shsuLpEVo.cELDplLGG...GsGVlpTISHEC+h.NSaQalFTCC	.........................Mcppp.......thhsulpEVS-cEL-pllGGt..GsGhhtTIoc-C........lhsCC..........	0	0	1	3
+3145	PF02502	LacAB_rpiB		Ribose/Galactose Isomerase	Main N, Bateman A	anon	Pfam-B_1105 (release 5.4)	Family	This family of proteins contains the sugar isomerase enzymes ribose  5-phosphate isomerase B (rpiB), galactose isomerase subunit A (LacA) and galactose isomerase subunit B (LacB). 	24.40	24.40	24.40	24.70	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.55	0.71	-4.53	170	5002	2009-09-12 00:30:27	2003-04-07 12:59:11	13	13	3211	88	900	2738	1726	140.00	34	86.39	CHANGED	+I.uluuDHuGhcLKptlhpaLppp...s..h.-VhDhGstst.-...ssDYP-huhtlAptVs......ss.c....s-..........h.GIllCGTGlGhuIuANKltGlRAAlspDshoAchuRpHNsANlLsl........GuRllG.tlAppllcs.......aLsscFc....GGRHtp..Rlspl....s	...............................................+IslGs.DcuuhphK....phlhpaLcpp......G..a..-Vh.Dh.Gst.st.p..............pscYPphuhtlAptVs.........ss.p.........s-..............h..GIllCGTGlGhshuANKl.GlRuAlsp..D...hoAhhs+pcNsuNllsh........Gu+ll..G..t.t...lAppIlcs.........alss.cac.....ssRppp+lstl.....................................	0	348	631	790
+3146	PF00356	LacI	lacI; 	Bacterial regulatory proteins, lacI family	Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.07	0.72	-4.34	26	29289	2012-10-04 14:01:12	2003-04-07 12:59:11	16	36	3489	72	5798	19321	1208	45.90	41	13.66	CHANGED	Tl+DVA+hAGVShuTVSRVlNss...t.tVSppT+c+VhpAhcELsYtPN	...............TlpDlAchAGVShuTVSR.VlNsp............s..pV..o..p..p.T+c+VhpshccLsYpPN........................	0	1667	3424	4636
+3147	PF02450	LCAT	LACT;	Lecithin:cholesterol acyltransferase	Mian N, Bateman A	anon	Pfam-B_2099 (release 5.4)	Family	Lecithin:cholesterol acyltransferase (LCAT) is involved in extracellular metabolism of plasma lipoproteins, including cholesterol.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.45	0.70	-5.50	7	1122	2012-10-03 11:45:05	2003-04-07 12:59:11	10	21	550	0	521	1745	75	256.00	21	58.91	CHANGED	hhplWLsls........hFh.hshssWh..hphVhspsst..hh..tPtsplcs....sGFs..ts.uhEhLD.shlsGhh...appllpsLsshGYctsphltAu.YDWRluss...cpscYappLKthIEphhphp.sppVhLluHSMGs.lhhYFLh...tph..........hspaIcuFIsluuPhhGSs+sltslhSG.......spshshl.s.sht........p.pRhhsspsa.....hhPps......hsh...--cl..ssssh................Nhshtsh.pahtslsht.h..........hh.app........................hssLpssLs.sPthclYClYGsshPT.csYhah..............sthhshts.ss..........hhhs-GDsTVshhuhs...........hCppWhstps...........hphsH....hhsl+s.......spHlsllhps	.......................................................................................h...............................................hp..t..............ts.th.............t.t........sh.....h...s......h............................................ht.......hlpt.L.h.t.......G.Y.......s...p....t..h...h.us....YD..W.Rhs.t......................t..p....h.h....p...p....L..t.th.l.............E.........p....h.....h........t.......h..........s.........p..................lh..lluHShGsh.h......h..h.......h.a.h...p..................................h...p...ph...l....t...th..l.lu.s...s.....h.h.G.s....t..s.....h........h.h........G......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t........................................................................................................................................................................................................................................	1	192	317	431
+3148	PF04369	Lactococcin		Lactococcin-like family	Finn RD	anon	DOMO_DM04110	Family	Family of bacteriocins from lactic acid bacteria.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.80	0.72	-4.05	3	23	2012-10-02 23:56:30	2003-04-07 12:59:11	8	1	16	0	4	19	0	51.00	27	76.43	CHANGED	MKNQLNFNIVSDEELSElNGGpLpal.SsGshsWYpsTsTuKTlsQQTpssauAshsshs	.............p.pap.lS-pELuplsGGshshhQs.sushshh.pt.sthhh.tQs.ssh.hth.s.........................	0	0	0	1
+3149	PF01306	LacY_symp		LacY proton/sugar symporter	Finn RD, Bateman A	anon	Prosite	Family	This family is closely related to the sugar transporter family.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.52	0.70	-5.92	4	1275	2012-10-03 03:33:39	2003-04-07 12:59:11	14	7	574	10	131	2345	309	380.70	39	96.84	CHANGED	hhsh+NpsFahFuhFFFFYFFI.MusaFPFaPlWLp-VstLoKT-TGIlFSClSLFuIlFQPlaGllSDKLGL+KpLlWsIohlLVhFAPFFIYVFuPLLQhNIhsGullGGlalGhlasAGuGAlEAYIE+sSRsspFEYG+ARhaGClGWALCAohAGIhFoIsPplsFWluSGhAllLhlLLhhuKs-sspoAhVhDAlGANppsFSh+hshpLF+..phWhFllYlVGVussYDVFDQQ.FAsFFpuFFsosptGT+lFGalTThGElLNAlIMFhsPhIlNRIGuKNALLlAGsIMolRIlGsuausoshEVlILKhLHhhElPFLlVGsFKYIousF-sRLSATlaLIGFphuKQLuhllLSshsG+hYDphGFQssYhlLGhIslohTlISlFTLSust..hlh.sst	............................................................h........h....h.ul.h...a..F..h.Y.FFh....h...u.h.a...h...P...F...a....s.....l...W..L.....+.....s.......h..G...L..o..s...s....s.....h.....G....lla....us.h.tL...hu.lh.h...t.s..l.h..G..lluD....+......L...G.h....+..K..h.....L.....l.....h......h...l......s....s......l...h..l..L...h.u......P.....F.....h....l...a....l.....a.....u.....P.....L.........L...p....h....N....h....h......h...G...s..l..l..G...u...l....a...h...u...h.....s...F..s.u..G.....s...s...h.h...-....A....a..h......-.+...h....u......R...p........s.......F....E......Y....G..+..s....R...h.....a...G.....S.l.G....a..A.l..s......u.....s.........l.....s..G.......h.........h.......a......o.....l........s...s.........p.........h.........s..F..W.....l...s..S...s.....................h...u...l...l.h.h..l...L...h..h...h...h.....+...s.....s..................p..s.........h...h.....p...s.......G....A.s....+...p....s..........h....o....h...t.....s.h......t.L.h..+.......p...h....W....h...h..l.....l...a...Vl....G...l..p.......s...s....Y.s.l....aDQQ...F...s.s.F.a.s.sa....F..t.....o...s....p.......G.....s...p...s.a....G.....Y....l..s....oh..G.l.h.E.uh.l.M.h.h....u.P..hl...ls.....R..l.G.....u.+....s..sLL.l..u.uh..l.Ms.....lR..I...h..G...s.u.h....s...T...s...s...h......l...l...l.l...K...h....L..Hs..h.....E.h....P.l..h..ll.u...s....F..K.YI..s....u.p.F.......-...s...+........l..S.u........T....l......a.h....Vs....a...s.h..u.p...p.l...uh...h...l...hSshA.....G......h...h....Y...........-.......p.........l.....G....ap..s...s....a...hl..h....u....h.l..s.L.h....h..hl.h.uhFh...Lpt.t........s.................................................................................................................................................................................................	0	19	50	90
+3150	PF00961	LAGLIDADG_1	Intron_maturase; 	LAGLIDADG endonuclease	Bateman A	anon	Sarah Teichmann	Domain	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.38	0.72	-3.46	91	1228	2012-10-03 01:41:40	2003-04-07 12:59:11	14	21	340	88	258	1340	92	96.80	21	50.58	CHANGED	lsGFhDu-GsFplshpppp...................ht.....................h.hpFplshc......c-htlLptIpphhs....................hGplphppss...shpaplss...p.hphllshFspYs..lhopKhhcahpapchh	....................lsGFh-....u...-GsFtlshpppp...................................................................................................phpI...s.p..............pchtlLphlpphhu....................................hGpl..th.....p....pspp...........hhpapl...ps...ppththlls..hh.....s...p.h......hho.p.K.h.h.pahhahp.............................	0	77	194	231
+3151	PF02264	LamB		LamB porin	Bateman A, Mian N	anon	Pfam-B_4810 (release 5.2)	Domain	Maltoporin (LamB protein) forms a trimeric structure which facilitates the diffusion of maltodextrins across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an antiparallel  beta-barrel [1].	25.10	25.10	25.10	25.70	24.10	24.70	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.45	0.70	-5.38	6	1601	2012-10-03 17:14:36	2003-04-07 12:59:11	10	3	781	33	201	906	30	388.90	35	86.13	CHANGED	FHGYhRSGlGhousGutppshps.stt.....uhGRLGNEs-TYsElpLupElap-ssKoahh-oMVAhus..stpNDWE.......................sus.shRQhN...VQuKsLlsahPtuTlWAGKRaYQR.+DlHhlDFYahslSGs.GuGIENlclGsGKlSlAhlRp...stshT.ssss......phssslhDlRLAslthhssusLEluscYupAN....p+Dstshp..tsuKDGhMhouchTQulhsG.FNcaVlQYuT.uthutshGphhG............stoph.h.stthcssussaRllsaGshslG-sWpluashhYptupDhh.......usps........h-hhoVsVRPMYKWsshhpThhEsGYpsscspssu..t.-csst..YKlTLAQsWpsGsShWu..RPEIRlaATYhchDcc.sphtshs................stscDsEasFGsQhEsWW	....................................................................................FpGYhRSGh.G..h...s.u........s.......G.ut.pps...h....t...s.......t...............Shh.RLGNE.s-..sYhEL....pLs.Qc..la...p...-..s...s...+.o.h.h..hss...ls...hsl........p.t.p.ssWp...........................uss..s...h..+...p.hs...V...p...sKsh.....l...t.a.....h...P.tu.slWAGKRa.hp+...aDlHMlD.ahh.h.s.h...u.Gs....GuG.lENhc.l.G...G..Klul...Ahs.Rp......................st.s........s.....t.spp...............................phsss.shD....l...Rhssh.....t..h..........s.s....u......sL..p.lusc..Y.up..uN...........pp.D...s........p...s........h.s.t...K...D........u..a..hh...os.p..h.s....Q.s...h....h.....p...G..a.NcFsl....Qh..As....s....hh...u...ps..hGp.....tG...........................stst..h.s..t..........hshpssG..p.hhR...llsp...Gt....h..l.u.Dp.aphh.shh...Yp.p......Dh...........s.s.p.u........................h..c.hosslRPhY.tWs.shhpThhElG.Ypp.hcsp..p......s..s.....................scss...........YKhTLAppa....p..s..G..s.S.hhu..RPtIRh.a..AT...Yhchs-p...s..t.t..h..shs......................csss....D.pa..shG......sQhEhWW..........................................................................................................................	0	19	67	132
+3152	PF03746	LamB_YcsF		LamB/YcsF family	Bateman A	anon	COG1540	Family	This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are subject to carbon and nitrogen metabolite repression [1]. The exact molecular function of the proteins in this family is unknown.	22.00	22.00	22.20	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.48	0.70	-5.27	15	2484	2012-10-03 16:37:10	2003-04-07 12:59:11	11	7	2180	4	565	1717	1361	236.60	45	95.10	CHANGED	plDLNuDlGEuFGsaphGs..D-pllplloSANlACGFHAGDPssMccsVcLAtc+GVtIGAHPuYPDLhGFGRRshslospElhshllYQlGALpuhscupGsplpaVKPHGALYNphs+DcslAcAlscAVtshDssLhLhuLu...GSthlctAcchGLpshpEsFADRsYpsDGpLVPRupsuAllcDs-pslpQVLpMl+cGpVpulDGptlslpADolClHGDsPpALthsp+IRpsLcpt	.............plDLNuDLGE.....uaG.a...p...hGs.........DpplLslVoSANlACGFHAGD..spsMppTVch.AhcpG.........VuIGAHPuaPDltGFG...RRs.h.s.l.s.sc-lhs.slYQlGALpuhs...+upG..splpHVKPHGALYNtuAcDtplAcA...l.scA.l.t.s..........h.........D.........s....s.......LhLhGLu.......sS...t.l.lctAcp.h..G.L.tshpEsFADRuYpsD...G....o.....LV.sRppsGA.llcDp-pslppslpMlpcGp.Vp.ols.Gp.hl..s.l............pAc....o....lClHGDs.pAlthAcclRpsLtt.p....................	0	150	310	461
+3153	PF02061	Lambda_CIII		Lambda Phage CIII	Mian N, Bateman A	anon	IPR000278	Family	The CIII protein from bacteriophage lambda is an inhibitor of the FtsH peptidase [1].	25.70	25.70	25.80	26.90	25.30	25.60	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.02	0.72	-3.98	3	144	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	136	0	0	39	1	42.50	77	81.18	CHANGED	MpaAIAGuAVMGlupLsESLLERITRKLRAGWKRLlDILNQPGVP	....MpaAIAGuAVMGhspLsESLLERITRKLRsGWKRLh-ILNQPGVP.....	0	0	0	0
+3154	PF00052	Laminin_B	laminin_B; 	Laminin B (Domain IV)	Sonnhammer ELL	anon	Swissprot_feature_table	Family	\N	22.40	22.40	23.00	22.50	22.30	22.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.70	0.71	-4.56	9	950	2010-07-04 11:48:03	2003-04-07 12:59:11	13	274	91	0	537	928	1	133.20	26	8.37	CHANGED	YWthPppFLGcplhuYGGpLcaolpast....ss.sp.upsDVll+Gsslplss.hhspstsh..s-shhchhhplhEsh...aphpst..lo+cchhplLuNlstlLIRAoY.upchsthpLssVoL-hA..+.sst......sAs.VE	.........................................YWthP.t.paLGs.p.l.s.SYGG.pL.pasl..phps....................ps...p....pt......s.....D..V.lL...............p.G..s...............s..............hp.l...h.h.............p..p.......s.ts.......t...p....h.........p.......ph.....p.l..p.l.p.E.s.....t.h..........h.................p....ts................st....................loRp-hhtlLusLpslhI.....RAo.....Y...sst..........t.p..s..pLssVsL-sA...p.s.ss.s.......A..VE...............................	0	124	168	337
+3155	PF00053	Laminin_EGF		Laminin EGF-like (Domains III and V)	Sonnhammer ELL	anon	Swissprot_feature_table	Family	This family is like Pfam:PF00008 but has 8 conserved  cysteines instead of six.	21.00	13.40	21.00	13.40	20.90	13.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.90	0.72	-4.03	72	16492	2012-10-03 09:47:55	2003-04-07 12:59:11	19	919	252	15	9516	15120	36	49.50	30	19.94	CHANGED	CsCsspus.t.....spCc.............oGpC..Cp.sstGpcC-pCtsGaas.........sss.sC	..............................................CpC.s.st.u................tpCs.....................................................sG....p..C......h..C.........p.....t.....s..........s.t........G..t.....p.C.....-.....p.....C.t...s..G..aas.............................................	0	2235	2973	5910
+3156	PF00054	Laminin_G_1	laminin_G; Laminin_G; 	Laminin G domain	Sonnhammer ELL, Finn RD	anon	Swissprot_feature_table	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.66	0.71	-4.14	21	1504	2012-10-02 19:29:29	2003-04-07 12:59:11	18	398	102	34	720	7364	51	130.20	24	13.02	CHANGED	F+TpsssGllh..Ys.Gptsct.........DahultLhsG+lphphchGss....tssltsssp.lsDGpWHplplpRsp+pssLpVs.spp........................tspsshusss....Lshss..LalGG.hP......thtttthshssu.hpGCl+plhlssp.lp	...................................................................hpT.sss.Gllh........Yt...uppspt........................Da.h..u.l.t...L..h..........s....G....+.....l...ph..p..........a..c.........h.............G..ss.................ssh.l..t.....s.......s.......s.......h.....l......s......s..G..p..W.....H.....p..l......p......l........p........R.................p........p......p...............s.........s........l....p..V..s..s..tss.............................................................pt.ps..s.h.ssph...........ls.h..p.s.......la.l..G.G...hP....................h..h...t..t...t...h.....t......s....h..........s.........s.......s.....a.p.GClcpl..lstp.................................................................................................	1	123	175	377
+3157	PF00055	Laminin_N	laminin_Nterm;	Laminin N-terminal (Domain VI)	Sonnhammer ELL	anon	Swissprot_feature_table	Family	\N	19.50	19.50	20.00	20.00	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.71	0.70	-5.37	9	1311	2012-10-03 19:46:52	2003-04-07 12:59:11	12	174	102	7	725	1124	0	213.80	31	15.25	CHANGED	CaPAhsNLhhstp..lououTCGh+tPE.aClloclpt.....cKpCalCDuppsh.t....ppHhhphlscsps.tp..sWWQSp...NGl.....VTlpLDLcttFchTalIlpF+.T.RP.ushllERStDhG.sWtsYpYauhs...Ccsoastsspss.+p....s-llCTScYS-IpP.pcGEVhFpsL-..Puh...Ds.SPclQphlphTslRlpLsRL+TLGDsLhs.........c.clpc+YYYAIpDhsVtG	....................................................P.hhshh.st....l....s...s...sTCG............................s............p.......aCh..h...s...t.......................................pC....hCDu.p..p..................................sH.s.p..h.h..D.h.p.....s............saWQS......................p..s...h...................................pVsl......sLs..L..t.p.....tFcls.a.lhlp..Fp....osR....P.sshll-.+...........S.hD...hG....poWp.PaQYauts......Ctptas.......h.sp.s.s..h..p.......p...........p-sl...C......o.....s..p.a...S....c..h...P.h...p...s.G.....p........l....h...........aph.......l....s............t............P..u.h......p.........h.......-.......s.......SstLp...........-a..hpsTslRlph...h..R..h.p..s.......h...s...s.p.h...hs..........................................p...t.s.h.p..pY.aY.ult-h.VtG.....................................................................	0	151	209	445
+3158	PF01299	Lamp		Lysosome-associated membrane glycoprotein (Lamp)	Finn RD, Bateman A	anon	Prosite	Family	\N	31.40	31.40	31.80	31.40	31.00	31.20	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.12	0.70	-5.28	25	515	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	100	0	288	524	0	247.70	23	80.35	CHANGED	YslpphohsYNhoDsshFPsuospsstTssstss..lpuslssta+Csusoslphs.sVs.ph.ssplpAahpssshSppcshCppD...pss.Pss..............s.sssPuPo...hP..sPs.lGpYsVssu..NsT.CLLApMGLQLNlTYppt.ssppssplhNIsPNs.TsssGoCssp.pusLcL....sspshphLsFpFshssp...scaaLptVslshsl.....ssuss..hFsssNsoLshhpAslGpSYpCspEQslplosshp.......lNsFslpVQAFplsssp.FusspECphD-s.shLlPIs.....VGuALuGLlllVLlAYlIGR+Ro+u.GYQol	..............................................................................................................................................................................................................................s.s............................s.Ps.......s....pst...hsp..Y..plpss....st..s..Clhhph.ul.plplp...ap....p......s....t...............h...t.th..hs..ls.s...st.....sps..sG..sC...........t.....s........p....p....s.pLpL............s.t...p.h...h......h..L.....sh....tFs..........h.....s..s.....t................ppa...hL..pp.lplshsh..............ssstt....h...h.ps.t......s......p.s.....h.....p.....h....h...p.....ss.l....G....pSYtCst.....p..p..s...lpl......s.ssh.p..................lphhslp.lQ..s....F.....pl...p...ss....p..F.u.s.........s...p...c...C..s....hD......t.........t....s.............l...lP.lh.lGhsL.usllll...l.ll...u..Y....hl....tp......+pt.....Y....................................................................................................	0	98	117	186
+3159	PF05147	LANC_like		Lanthionine synthetase C-like protein	Moxon SJ, Finn RD, Fenech M	anon	Pfam-B_6095 (release 7.7)	Family	Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs [1]. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains [2]. This region contains seven internal repeats.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.52	0.70	-5.89	47	1539	2009-01-15 18:05:59	2003-04-07 12:59:11	8	21	836	8	490	1232	30	282.40	16	54.42	CHANGED	s.hshsLYsGhsGlulhhhphh..chhss.tp...hhph.spphlpphtpthppt............shohasGtuGlhhshthhsphhsp.pth.tphlpphhphh.pphtttt...............DlltGt..uGhlhhllhl.....p.h.tppph.....chlhphspplhpstpp..............p.hh.p......tsph...hGhAHGhuGlhhsLh.phhhp......hhtp...pphhchlcpslphhhphp..pp.ss...a.sthtpp...............stWCaGssGlhhsh.........hphtpsh.pcpphhcthtpshph.shp..ps....hhpshslCHGsuGsh.hhhhhtchhsppp..h.phtpph...hp.lhshtpp.h...........hstpss.spshuLhpGhuGhh..hhlhchhsspps.......sshhl	.........................................................................................................................t......h..G..Ghhhhh..h............t...........................h.th....h.t.h.....l.....pt.h.....ht............................thuhh......G..s..G..hh.h.h.hh..........h.h.........p.h......t.........p..........h....phhp....t.h....h....p..h...t...h..t......................................................-h.h.Gh...uGh...hhh...l..lhh............p.h...tptph............ph.lh.p..hh.pt...lh.t.th.t...............................................................t......hGhuHG..h......sGhhhhLh...h........................hht.........thh....ph.....lpthh...t....h...phh.......ttt..........h........t..................................................tWChGssGhhhhh.....................hht......h.....h...t...p................p....h..p..h...p....h.hp...hhp........tt...........hht.slCHG.sG....h..h.h...........h..h..p...........ht.t........h.....hh..t.h.................ht..h..h..t............t............................................................shh..G.sGhh...h.h.t..............................................................................................................	0	162	275	398
+3160	PF04738	Lant_dehyd_C		Lantibiotic dehydratase, C terminus	Kerrison ND	anon	DOMO:DM04916;	Family	Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides [1].  They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin.  Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues [2].  This family constitutes the C-terminus of the enzyme proposed to catalyse the dehydration step [2],[3].	19.80	19.80	20.10	19.80	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.54	0.70	-6.26	37	446	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	278	0	138	401	8	415.20	17	49.92	CHANGED	l....phscLlpplspphsshssptl..cphLppLlppphLlosLcsshssscsLpallstL................tshsttsp.hhptLpplpphltpasp..tshupttphhpplppphpplh........ss.....ps.LtsDhhhssp........lplspsltpphtpthphlhplssths...spt.thppa+ptFhc+Y..G.........sp.Vslh-hlssstGlGhP.sh...........shspttpcp.hthhtphhptslpsp.pclsLs-p..tlppltssss............h.sos-lhhplps...ptlppGphplhlsshh..tuh.susshGRFt...........tppppltpphtphhpsh.........sh.splshhstpt+stNVhps.phh....sphlsl.sptss.sp...ppltlsDlhVs....ssspplaLhshs.p...pphlh.hssshhsht...phPslhRFLh-lu....t...ht......hshtt.hpthsah....PRIpatchlls.t+Wplsst-lss.....thppatthht..pa+pphplPcplalt............psD.................phlhlDlcsshplplLtpplc.+psphpl	...................................................................................................................h..l..t.......t.h...thltpL...lppthlh....p...lp.s........pshphlhphl....................tttt...hhttlt.pltthht.....thtt...tt.stt..thhtpl..pthptlh...............................................................................pt.l.hDhhhsht....................lst.phh.p.p.l.t.t..hth..lh..hs.........t.t..hpthppt.F.h.c.+a..u.................tt.V..slhphhtt...hu..hshs..............................................t...t......h..ht....ph....h..t..s..ht.tt...tp.....l.lspt........lpthh.p.................h..ph-lhhthht................tt.....t.......p.hlhls.hh..hs....h..uthh.uR.Ft.....................................tph..t..t....h...tp..tt.............s..spl...s.h.s......p.ttNl.htp.....h.....th.lsh..tt.ss...t...........ttl.lsDlhls....sp..ttpl.hlhs.p..h....sp..lh.h.....sh..hs............s.hh+.hLhpls..........................................h......h......tths....ah............P....Rlph.t.p.lllp.tpWplstt..tlsh..............p.t.......htth.....h.t...pappph..p..lP....phlhlh..................ttc..............................p.lhlshppshphthlhpthp.p......................................................................................................	1	60	101	119
+3161	PF04737	Lant_dehyd_N		Lantibiotic dehydratase, N terminus	Kerrison ND	anon	DOMO:DM04916;	Family	Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides [1].  They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin.  Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues [2].  This family constitutes the N-terminus of the enzyme proposed to catalyse the dehydration step [2],[3].	22.80	22.80	23.20	23.70	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.20	0.72	-3.97	38	378	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	260	0	115	326	3	93.90	23	10.55	CHANGED	hp-AlhhuSssLhppltp.......htss....hps+chRphtpulhpYlhRhssRsTPFGhFuulshGpa......sppsss.phsssp..+ppsphDhtaltplspplcp	.......................pEulhhuossLhpslpp.................htts......hps+c..h+.p..hppolhcYhhRhssRsTPFGhFuuluhuph............ssps...sh........ph..s..ssh......ppts..ph-ttalhplsphlt.t...............................	0	47	82	100
+3162	PF00500	Late_protein_L1	late_protein_L1; 	L1 (late) protein	Finn RD	anon	Pfam-B_69 (release 1.0)	Domain	\N	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.57	0.70	-5.96	19	3438	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	304	77	0	2486	0	179.90	45	98.21	CHANGED	lWhPupsKVYLPPs.PVo+VlsTD-YVsRTsIaYHAuSsRLLTVGHPYaslppss.....p+hsVPKVSu.QYRVFRl+LPDPN+FuLPDpslaNP-pERLVWAstGlElGRGQPLGVGloGHPhaNKh-DsENssthtssstp......DsRpsluhDsKQTQLhIlGCsPslGEHWspupsCssstsp..G-.CPPlELhNosIpDGDMsDhGFGAMsFpsLQusKSDVPLDIssolCKYPDYL+Mus-sYGDSMFFahRREQhasRHaasRAG..ssG-slPsshYlcu..........t.....psshuoslYhsTPSGSlVoSDuQLFN+PYWLQRAQGpNNGICWsNQLFVTVVDsTRuTNhoIsssspss.....ssYssocF+cYlRHsEEY-LpFIhQLCKlsLTsEshuYlHsMssoILEsWphGlsPPPsssLEDpYRalpS..AhpC.cssPPpcpcDPYpch+FW-VDLpE+hSh-LDQFPLGRKFLhQsGlpppsphpspphp..sssssssppssKR+R	.......................................................................................................................................................................................................................................................................................................................................................................................................................................hDsTRSTNh.olssthpst..........ssYpss...paKcYhRHs.EEa-LpFl.FQLCplsLss-lhshlpsMssslL-sWphGh...s..s..ssssl.DpYRalpS..AhtC................................................................................................................................	1	0	0	0
+3163	PF00513	Late_protein_L2	late_protein_L2; 	Late Protein L2	Finn RD	anon	Pfam-B_39 (release 1.0)	Family	\N	20.40	20.40	20.50	21.80	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.66	0.70	-5.63	29	499	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	258	0	0	495	0	460.80	41	97.13	CHANGED	R...s+RpKRASATpLYpTCKtuGTCPPDVIsKVEtoTlAD+ILpaGSlGVFFGGLGIGTGuGoGGRTGYlPLG.....tsshssssssssRPPlllE...........sVuPoDPSIVSLlE-ou.....................hIpuGAshsshssss...GFslToSus...sTPAlLDlo....ssspoh.losTpapNPsFs-Pohlpsst.suEsoG+lllS....ssTluscs............hEEIPhcTFss.ss..ss.sshSSTPlPssppsst.t...LYoRshQQ.VpVsDPsFLopPpc....LlTaDNPAFEs.p..sTLhFpps...hptsPDsDFhDIltLHRPAlTo.RcGtVRhSRLGp+uThpTRSGppIGARVHaYpDlSsIsst.......-tIELpsLsttussss.............psuLaDlYs-.....sss.s..........hhpss.h.....pshsss.ss.ss.sspssNsTlPhspshcssh.sGPDlsh......Psss..sssshhPhsPshPshsIhlpGs....DFYL+PShahh...+RRKRlsh	....................upRpKRASATpLYpT..CKtuG.TCPPDVIsKVEtsTlADpILpaGShGVFFGGLGIG.TGu.G...T.GG.R..T........G...Y...l.PLGs........pssp.s..sss..........s.......s...ss......R.P....P...l..s.l-...................................sVuPs..DP..SIVo..LlE-.ou.......................................hI-uG.A.s.ssshssss.........GFs.lo...o....oss.........sTPAlLDls..........................sss..p..s......h...oso.s....apN...PsF...s...-.P...ol...l...p...sst....su-s.u...G.clhlo...................ssol.uscs.......................aEEIPh....cT.....F..h..s...........ps........ss............sspSST.P...l...Ps.s...c..t.s....s...pht.............LYuR.....s.h.Q.........Q.............VpV........sD.P.sFLop.Psp....llT..a..D..NPAaEs....sTLhFpps....h.p..APDPDF.h..DI..ltL.HRP.A...lTo..RcGs.VRhSRlG.p+.uT.l+TRSGppIGA+VHaYpDlSsIsss................Ep..IELQsLss.....s.ssss.........h.................pssl..aD...lYu.-s....s.......s.p...............t..h......s.ssst......shs......s.sp.p...s.s..ss...T...l.Phs.s..s.h.s...ss.l...h.s..G..PDlsh..........................ssss.....sssshh...Ph.s...P.....h.....s...Pth....s...l..h.lpuu........DFaLHPShhhh...++RKRh...................................................................................................................................................	1	0	0	0
+3164	PF02354	Latrophilin		Latrophilin Cytoplasmic C-terminal region	Bashton M, Bateman A	anon	Pfam-B_874 (release 5.2)	Family	This family consists of the cytoplasmic C-terminal region in  latrophilin.  Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin  family of G-protein coupled receptors that are involved in  secretion [1].  Latrophilin mRNA is present only in neuronal  tissue [1].  Lactrophillin interacts with G-alpha O [1].	19.30	19.30	69.20	20.30	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.07	0.70	-5.74	3	436	2009-01-15 18:05:59	2003-04-07 12:59:11	11	23	39	0	132	329	0	235.30	47	23.71	CHANGED	RHhHCCShhPpG..RSol.ESopcoGupSGSGsPhpauh.oQSRIRRMWNDTVRKQSESSFIoGDINSTuTLNRGsMGNHLLTNPLLRPHGTNNPYNTLLAEoVVCNsPSsPVFNSPGuhhp..HsL.NuRDTSuMDTLPLNGNFNNSYSLRSGDY..uDGVQllDRGhNLND.TAFEKMIISELVHN......NLRGtSucs+ss.hchPVsPVsG..uSEDDAIVsDuAo...HtDssGLELlHKELEAPLLPPRsaSl....LYQss.....p....DcSESasupLTAEucEcLQSPsRDSLYTSMPNLRDSPoYP-SSP-s.sEsLsPPPPAcsGssE.IYYKSM.PNLGARN...QLQsYYQluRGSSDGYIlPPNKEGssPEG..D...GQMQLVTSL	..................................................+oaCC.....t...+uo..tSsht.ostp...sot...................................oQSRIRRMWNDTVRKQoESSF.hsGDIN...........SosoLNp.........t..............................................................................ss..R-sssMDTL...PLNGNas.NSYSlttspa........tss...s..t..s......h....s.ht-.sshEKhIlpELspN.......N.+........t.t.......................................................h.....s.......................st...cpp..............s..hh.st.........................tt........tlEhh.....h.....p.t..ptPLl....R.....s..s.....................................................ttsto.hs..s..t...............t........t...............................ss....tRDSLYsShs.Lts.s.........................t.........-........................p..Yh.uh.PtLsst.........hYph......t.pG.......-.....s-t.........t...phlTSL..........................	1	4	16	60
+3165	PF01273	LBP_BPI_CETP	Lipid_binding_gp; 	LBP / BPI / CETP family, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.	28.30	28.30	28.80	28.30	28.10	28.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.85	0.71	-4.90	36	774	2009-01-15 18:05:59	2003-04-07 12:59:11	20	9	110	3	412	720	0	166.10	17	38.69	CHANGED	uLphssp.uh..h.t.Lpplsls-hhssht.t..u....................th.hshhslcIpshplsp.hplchhssssh.hhsth......ssslplps..ph.hh......t.shlcl.........shslslpsplpltp-sp.GcsplshusCssshsslplpl.ss.....hshlhshhpshlppsltpllpsp....lCsll.....psh...Lpsl	.................................................................l..h..t.sh..htpt.l.p.p.hplsshhsp..s....h...........................ph.hslpsl..plpphplsp..splph.hsstth.hh.h...............ssslslps....phtht.............t.thlch.................hhslslssplpltpssp.Gpspls.h.s...sCsspls.......p...lplphtss.....hshlhph.h..p.s....h...lpp...sl....pp....hlpsp........lC.hl........sth...h.................................................	0	64	88	182
+3166	PF02886	LBP_BPI_CETP_C	Lipid_binding_gp; 	LBP / BPI / CETP family, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.	20.60	20.60	20.60	20.60	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.42	0.70	-5.14	10	709	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	111	3	395	669	0	211.60	20	46.01	CHANGED	ssLDlhhK......G....EFFshsc+sPsshsssshslP..pscsRMVYhulSDahFNoAshsYacuGaLpholssDhlPs-sslR...Lso.....psFushlPpLActaPshslcLpssssssPhlshpss.slslpsshslpsallh..Psu.s+pslaplshssssosslohpsc+lsGpLchc+lplcLpcSclG.hssEhlpul.LNhhlsshlhPtlN-+Lt+GFPLPLP.ctlpL..aclt...LpsHcsFLhlGADlpa	................................................................................................................................tpppMlhhhlS-ahhs...ohhhhh.p..s..Ghlphsl...s.s.p..ls..p............hh..........so.............................pshu.hlsp.l....s.p..t.a.P.s....t.s.h..lpl...p.s..s.p.s......P.h..ls.......hpss...sss..l..p..ht..ss.l.p.hhsh.......s......ss...s............tsl...............hplshs..s.s......h..ss.p....h.s.h..p....s.....p.......+....L..h.s...p....l.p.l..p.p..h.p..l...p.......h..tp.S..........pl.s...h..s....h.t....l.p.sh...lp.hlphsh...hP..hlN..t..h..L.....t.....tGhs.lPh.....ts....lph....hs......l...hhpshlhlt..................................................	0	92	125	231
+3167	PF03815	LCCL		LCCL domain	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Domain	\N	22.60	22.60	22.60	23.40	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.47	0.72	-4.00	68	852	2012-10-01 19:31:27	2003-04-07 12:59:11	14	48	198	1	528	762	11	100.40	30	19.17	CHANGED	lsCpsphtpht..........h....hssphhhpCPssC..tpst...splhGot......................lYsssSSICpAAlHuGll.................sspGGplslphhsshppYhuo..p....pNGlpS...tsh..t....tpuF	........................................................pC.sph.p.t.................ssp.hthpCPusC..tpsp...............splh..Got..................................................hYp.s..sSolCpAAlHuGVl.................sspG.G.tlsVt.h..h...s.s..p..p.p..Yh.uS......h....pNGlpS....sh...............................	0	140	228	365
+3168	PF04072	LCM		Leucine carboxyl methyltransferase	Wood V, Finn RD	anon	Pfam-B_5898 (release 7.3);	Family	Family of leucine carboxyl methyltransferases EC:2.1.1.- . This family may need divides a the full alignment contains a significantly shorter mouse sequence.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.09	0.71	-4.72	211	3171	2012-10-10 17:06:42	2003-04-07 12:59:11	9	48	1290	36	972	2545	132	173.20	26	52.57	CHANGED	AlhsshsRAhcspt.s...ssllpDshAttllpsh.......................phshtt..............h.thttt...hs.sRs+ahDchhtpth..tsG...htQlVlLuuGLDoRuaRls..t.........ssplaElDhPpllphKpphLspt.sp.....................s...hh.h..lssDlp..psWhssLttt..Gap.ssp..........P...shalsEG.llhYLst-shppLlppls	.......................................................................................hhshhtRAhtspt.s.............psllp..DshAt.hlpth............................................................th..tt....................ht.t.h.t.tt......hs..sR...sphhDp....hhtphh..........tss.....................htQlVhLuuGLDo......R......sa.RL.s.............................tsp.ha.E.....lDh..P.p.ll.phKpphltp...t.tt.p.........................................................................................t..thc..h.........lssDl....p...t....p......s....W.....s..s....L.ptt......shc..sst.............................P......shhluEGl.lh.YLstp.t.ppLlptl..........................................................................	0	293	586	821
+3169	PF04792	LcrV		V antigen (LcrV) protein	Waterfield DI, Finn RD	anon	Pfam-B_6155 (release 7.5)	Family	Yersinia pestis, the aetiologic agent of plague, secretes a set of environmentally regulated, plasmid pCD1-encoded virulence proteins termed Yops and V antigen (LcrV) by a type III secretion mechanism. LcrV is a multifunctional protein that has been shown to act at the level of secretion control by binding the Ysc inner-gate protein LcrG and to modulate the host immune response by altering cytokine production.  LcrV is also necessary for full induction of low-calcium response (LCR) stimulon virulence gene transcription.  Family members are not confined to Yersinia pestis [1,2].   	25.00	25.00	61.00	41.50	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.84	0.70	-5.40	2	127	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	82	1	10	81	0	260.30	49	80.26	CHANGED	.lRshpts.phFl--L....ltt.su.uSu..EELltLl+scpIsluhthpPhp-upV....................L.t.AhLhuup.ss..tpGlchl+EhLpu..pPssQW-LRtFhsshaFSLpu.RlD-DlltVhhDshpppsstRptLh-ELttLTAELKlYSVIQupINttLSuttsIpIcstuIsLhD.sLYGYs.s-.haKsSsEYtlLpph........-T.pthlSIKsFLpup.KpoGtLtsLpDpYsapKDNN.lupFATTsSD+SRPLNDhVspKTT.LsDhoSRaNSAlEALNRFIQKYDSVhpclLssh	................................................................................................l.shpts.thFlt.L....ltt.su.tss..pELltLl+scpIslu.ht.pPhp-.ups........................L.t.Ahl.u....up.ss..ttG....lthl+phLps.....pPs.spWpl..RtFhslhh.SLpuDRlD-Dlltshs-shsp+sstRppL+-ELt-LTAELKIYSVIQucINptLSs...sus...hphcspuhN....LhDhsLYGYs.s-thF..Ks.....SsEYKlLpch.............t.........spppl.lolKsFLtupsKpo...Gsluslcs.pYpapKDN.NcLupFuTosSD+SRPLND.VspKTTpLsDloSRaNSAlEALNRFIQKYDSlhpclLssh.............................	0	1	3	4
+3170	PF00056	Ldh_1_N	ldh; 	lactate/malate dehydrogenase, NAD binding domain	Bateman A, Eddy SR, Griffiths-Jones SR	anon	Overington enriched	Family	L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family.  Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.60	0.71	-4.36	31	12983	2012-10-10 17:06:42	2003-04-07 12:59:11	18	15	8382	421	2210	8108	2565	125.70	35	47.64	CHANGED	hKVullGA.GtVGpuhAhtlhtp.slucE..........LsLlDlspp..tscGsAhDLpHusshs.ssshlss...sshsshcsuDlVllsAGsspKPG.o.....RhDLlptNspIh+slssslscsu..ssuhllVloNPVD....IhshlhhKhushspp+lhG	.............................................pl.lhGs.G.lG...........sh.............h......h..h.t........s.t...................l.l....h-.....h.............hh.G.s....h.-.....ltc.....h...........................h..................h.................p..............s........h...................s...........s..........t..........s......sh......ssh.c.sADl.Vl...l...o..A.....G....s....s......R....K......P......G..M..s....................Rt.........D.L..h..s....h....NstI...h....Kslsppls.p.s...s........ssu...h.ll.l.l.oN.P...Vs....lhs.l.h.p.Kh.u...s..hspp+lhG................................................................	0	689	1286	1790
+3171	PF02615	Ldh_2	ldh_2;	Malate/L-lactate dehydrogenase	Bashton M, Bateman A	anon	COG2055	Family	This family consists of bacterial and archaeal Malate/L-lactate dehydrogenase. L-lactate dehydrogenase, EC:1.1.1.27, catalyses  the reaction (S)-lactate + NAD(+) <=> pyruvate + NADH. Malate dehydrogenase, EC:1.1.1.37 and EC:1.1.1.82, catalyses the reactions: (S)-malate + NAD(+) <=> oxaloacetate  + NADH, and (S)-malate + NADP(+) <=> oxaloacetate + NADPH respectively.	21.50	21.50	21.90	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.82	0.70	-5.72	8	2631	2009-09-11 11:09:40	2003-04-07 12:59:11	9	4	1423	44	609	1711	3069	322.80	31	94.97	CHANGED	M+lshEpL+phIpcVLpphGlsEEcAchVADshlcADL+GhpSHGlsRhPpYlppLppGsIsscsch+hlcpususullDGDcuhGpVsA++uM-hAI-pA+ppGVGlVul+NuNHaGtuGYYuppAAcpGhIGIshTNoc..PhVsPaGG+EshlGTNPlAlAhPupc..hhhlDMATSshAaGKlhsARc+GcpIP-ssulDc-GssTTDPshlhcs.t..lLPhG.......GaKGYGLSlhlDlLuGlLuGushuspVopssss.--tsspsplaIAIsP-hFhss-pFcp+lsphh-ElKuSp.usthpplhlPG-hpshphccpp+pGIslDcslappLpsl	..................................lshppL+p.hhpplLpp.tGhspppApt..lA-hLltAshpGh..pSH.Gl...s...Rl.st..Yl.pplppGt.lp..s.s.p...s.plh.p.p.s.su..h..shlDucpuhGplsuctuMstAI-....h....A.cppG.luhVul+...s.u.s.HhGthuhaspp.sAc.tG.hl.........u..l.shs....s..os....sh...lsP.aGGp-shhGTNPlshu..hP.........s................p......s.........t.....shllDhATSshAhGKlpssp..ppG..c..p.lPs.shulD.p.p.G..p.s.......T...sDP....t.....s....h..................p..s..h.............h...L.P.h.G.........................taK.G.GLuh....hl-lLuGsL.s.Gu.s..h...s..t.......p.......l........s.....p...........h...s.....s.......t.ps...t..h.....s..phhI.s.IcPshF....s..s.....t..t..h.p..tc..hp.p.hhchlpsst....ts..s..p.tlhhPG.c.p.htt.t.p.c.s.t.p.p.G.I.slssshathl...t......................................................	0	183	341	493
+3172	PF02866	Ldh_1_C	ldh_C; 	lactate/malate dehydrogenase, alpha/beta C-terminal domain	Bateman A, Eddy SR, Griffiths-Jones SR	anon	Overington enriched	Domain	L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family.  Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.	22.60	22.60	22.70	22.70	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-4.53	19	12166	2012-10-02 13:39:36	2003-04-07 12:59:11	13	14	7571	421	2231	7218	2555	135.60	32	49.53	CHANGED	TpLDpsRupsh...........lAc...ttsl.sPpsl...pVhllGsHus..........lshlPl.p.sp..sphs.cpplpplhpplppuGscllctKt..GSsshShAhAhs+....hscullpsh......pshh.huVhpsu..husps....................haauhPlhlstsG.....lpcl.l-.hs.Ls-hEccthp.putspLcpplcpuhphh	................................TsLDssRhcsh.................lA-...............hhsh..ss.ps.l............cs.llGsHu...........s...................................V........s.......h........l.......P.......L....h....s........l....p...............................t.........s.....t.....t.....h.....t...tl....h.t.....p..h..tp..t.u...hpl....lph.+.................sus........hu..h..u.uhhp.................hsp...sh..h.ts.................................pt........hus.h....p.......u........ht.......t...........................hhhu.Pshls...p.G.......h.ph....hp.......h.....l..s.t..p..tt..ht...t.h...t.l.t.........h.......................................................	0	697	1291	1800
+3173	PF00058	Ldl_recept_b	ldl_recept_b; 	Low-density lipoprotein receptor repeat class B	Bateman A, Sonnhammer ELL	anon	Swiss-Prot	Repeat	This domain is also known as the YWTD motif after the most conserved region of the repeat.  The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.77	0.72	-3.63	28	8618	2012-10-05 17:30:42	2003-04-07 12:59:11	12	734	140	112	4691	7279	7	41.70	31	14.93	CHANGED	splYWoDhs.p.....sluhsshsGss..pcsllspc........lppPpuIslDh	.............tplYWo..D.hs.pp.............pIc.pu...s.h...c....Gsp........Rps.l..l..sss............lsp.Pp..ulslD....................	0	963	1312	2717
+3174	PF03760	LEA_1	LEA-group1; 	Late embryogenesis abundant (LEA) group 1 	Finn RD	anon	Pfam-B_1549 (release 7.0)	Family	Family members are conserved along the entire coding region,  especially within the hydrophobic internal 20 amino acid motif, which may be repeated.	25.00	25.00	26.10	26.10	22.70	21.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.55	0.72	-3.83	8	153	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	36	0	41	142	0	71.70	43	51.71	CHANGED	MQSuKEKhoNhASoAKEph-lsKAKs-EKAEKuTARoctE+clAHp+cKAKEApAcM-hHpAKAcHAA-K.ps	.........hpohKEpspNhuuuAKtth-hsKAplpEKAEKhTARs.hcKclAcc++cAKhspAch-h+pA+tcpsAtK.t.t........	0	3	22	34
+3175	PF03168	LEA_2		Late embryogenesis abundant protein	Mifsud W, Griffiths-Jones SR	anon	Pfam-B_3080 (release 6.5)	Family	Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress.  The function of these proteins is unknown.  This family represents a group of LEA proteins that appear to be distinct from those in Pfam:PF02987. The family DUF1511, Pfam:PF07427, has now been merged into this family.	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.19	0.72	-3.63	144	1601	2009-09-13 08:28:33	2003-04-07 12:59:11	8	14	422	3	862	1521	41	100.30	16	47.34	CHANGED	plplpN.PNs.hs.lsh.ssls...hslt..h.....su....ptlu..t.us.spshplsspups....hlsl..s.....lplshts.h.........hphhtshh...........hstplshplcuplp.h.h.h.hthsl.shspps	....................lplpN..PNp..hs.lhh..sshs......hplh..h.........ps............ptlu.........ssthssht.h.stp.s.ss..............slsl......s..............lsls..sht.h..................spth..t..s..hh....tt..................hshplphplcs....chp......hh..h..hphph..ht..................................................	0	152	498	703
+3176	PF03242	LEA_3		Late embryogenesis abundant protein	Bateman A	anon	Pfam-B_3170 (release 6.5)	Family	Members of this family are similar to late embryogenesis abundant proteins.\	   Members of the family have been isolated in a number of different screens.  However, the molecular function of these proteins remains obscure.	21.00	21.00	21.40	21.00	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.54	0.72	-3.74	13	167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	52	0	57	159	0	86.70	32	82.53	CHANGED	MARSlo.suKhlSAhlsDslSsh.hpRRGYAAAust..hsu.....hRuGustsss.hts+suEs.....sstssuWsPDPVTGYYRPEspusEIDsAELRphLLs	...................................................................................t.h................ppRuYuA....uAst...httu.........ts.us.s.tphs.......tt..scssts..............spcpssWhPDPsTGaYtPEs.phsE.lD.sAELRttlLp.........	0	7	30	43
+3177	PF00059	Lectin_C	lectin_c; 	Lectin C-type domain	Sonnhammer ELL, Griffiths-Jones SR, Eberhardt R	anon	Swissprot_feature_table	Domain	This family includes both long and short form C-type	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.85	0.72	-3.39	95	12227	2012-10-02 16:37:33	2003-04-07 12:59:11	16	665	521	504	7014	11645	360	107.50	20	30.77	CHANGED	pthsapcApthCp.p...hsupLsshps....tpchchlpphh...........sspphWlGl.......ttpptsapW.sssshp...........................spsspsppCshl............sssphss......psCsp.tphhlCcp	.......................................................................................t..hsappA..p.p.hCp..p............ts....u..p.L.s.s..lps.....................pp.E..p..p...a....l.tp.hht................................tppthW.....l.GL..................pptppps...p......a.p.W.s..D.u...s..s.h..s............................................h.tW..........................sst.ssspsCshh.................................ttsspW.ps..............................ts..C......p....p....p......h.........a..lCp...........................................................................................................	0	2294	3027	5110
+3178	PF03041	Baculo_LEF-2	lef-2; 	lef-2	Bateman A	anon	Pfam-B_1773 (release 6.4)	Family	The lef-2 gene (for late expression factor 2) from baculovirus is required for expression of late genes. This gene has been shown to be specifically required for expression from the vp39 and polh promoters [1].  LEF-1 is a DNA primase and there is some evidence to suggest that LEF-2 may bind to both DNA and LEF-1 [3].	25.00	25.00	60.10	58.10	20.00	19.50	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.22	0.71	-4.57	11	69	2012-10-01 20:20:07	2003-04-07 12:59:11	9	1	62	0	0	68	0	164.60	35	79.78	CHANGED	ph.lhapP...tpsIDcstpYlVchpsas..lslosYTsFppsGLhVhlsGhpLhpLlcsssstppssssp.........tpp+sp+NVCFpssss.s+psllshLpsplp...hPsChpphhpclpsp..PRssRaRKRFlFNsYlsNsloCs+Csp.pClhcAhphhYptDpKCVpElpp	.........h..hWsP..ht..t..sslDK.sts.YhlchpDa...lsloPYTsFhpsG.hhlclsGhR.Lhh...Llpssss.ppp.psst..................hhc+Sp+NVCFpsstp.t+psllchlppplp....hPsC....hpph.hssLp..hp..PRGsRa+KRFlFNsYIuNlloCsKCcp.pClhcAltthYppDsKCVpElp...	0	0	0	0
+3179	PF03388	Lectin_leg-like		Legume-like lectin family	Mifsud W	anon	Pfam-B_2789 (release 6.6)	Family	Lectins are structurally diverse proteins that bind to specific carbohydrates. This family includes the VIP36 Swiss:P49256 and ERGIC-53 Swiss:P49257 lectins. These two proteins were the first recognised members of a family of animal lectins similar (19-24%) to the leguminous plant lectins [1]. The alignment for this family aligns residues lying towards the N-terminus, where the similarity of VIP36 and ERGIC-53 is greatest. However, while Fiedler and Simons [1] identified these proteins as a new family of animal lectins, our alignment also includes yeast sequences. ERGIC-53 is a 53kD protein, localised to the intermediate region between the endoplasmic reticulum and the Golgi apparatus (ER-Golgi-Intermediate Compartment, ERGIC). It was identified as a calcium-dependent, mannose-specific lectin [2]. Its dysfunction has been associated with combined factors V and VIII deficiency OMIM:227300 OMIM:601567, suggesting an important and substrate-specific role for ERGIC-53 in the glycoprotein- secreting pathway [2,3]. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.52	0.70	-5.24	8	783	2012-10-02 19:29:29	2003-04-07 12:59:11	8	10	280	35	470	811	29	200.80	27	52.53	CHANGED	cpacpcaSLhtPahspupsslP.hWcatGsshlo.SstIRLTsc...pSppGulWs+psshh.csWElclsF+VsGptt.pltuDGlAlWYTp-psh..sGPVFGusDpasGLuIhlDoasNcsss.p+spPalsuhlNDGohpYDHscDGspspLAu....Cpt.cFRNp-asoplpl+YspshLolhh-.s.lcsps-achChplssVpLPsGhY.FGlSAsTGsLuDsHDlhShhhhplps	........................................h......hoh..P...h....s.......s.....tt.h....s.hWph.tG..s..s...h...h........p.....s....p......h...l.RLTssh.........ps.p.p.G........s.l.Ws..c.sh.................h...p......sWc...l...............clp..F+l.........p.........Gp............t....ph...t..u...D..G.hAlW...h.sp......ppht.............G......s......l....a...G.s...s.....pa.pG.....l....ulhh......Do....a...Np............t....................................t.....hP..h...lps....hhN....s......G..s..h...p..Y-p...ppD...G....p..t..p...t....l..uu.......Cph.........t....h.....R........s...t...s.....h...s.........o....phpl..pY.h..p..t.....h...p..l.................h.....s.............h....p......sp...tp......a.p..........Chp.s....p.....s.....l...t...l.....P......p.....s......h......a.....hGhS..At.TG.......s.L......u.D........sHDllphhhht.............................................................................................................	0	158	234	362
+3180	PF00139	Lectin_legB	lectin_legB; 	Legume lectin domain	Sonnhammer ELL, Bateman A	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.90	0.70	-5.00	47	1651	2012-10-02 19:29:29	2003-04-07 12:59:11	14	73	320	724	782	1765	72	204.20	27	39.67	CHANGED	ssspFsa........ssF......st......ssLhLpGsApl........ssGhLp.LT.......sssp.......pshG+AhYs.pPlpl...hssssup....h.......sSF.sToFsFsI..h....ssssucGlsFhluPss....ssu..sutaLGLhNtpsss......sspllAVEFDTht...php-hDs....NHlGIDlNSlpSsto...sh................tshsLsu...GpshplaIsYcussppLsVslu.s..p.............cPpp.sllStsl.DLss.lls..-......psaVGFSAuT.G........hsptHhlLuWSFs	..................................................................................t...a.h........t.a......tt.........ts.l....h...Gs..A..h.........ss..s.h.lp..LT.....pst.....................tthG+shas.tP.lph............hp.........s..s..t..........h......................tuF.so...pFsFs.l....................................t........s............suc...........G....huFhls..sst.......sh.sts......suth...L....G...l..hst......p....stt.....................psphlAV...EF...DT.hh................t.....t..c.hss...............sH.l.G..l...D..l.......N......u....l..h.S....h..t..s...........................................hsh.s.lt.s......up.......hpshlsYsu.s.s.....p.......hLsVsls.....t...........................pspp.....h..lo.h....l.....sL...ps...h.l.s....-.............shlGF....SuuT..G.......thh.pt..p.lhuWsF.............................................	1	114	409	591
+3181	PF03954	Lectin_N	lectin_N; 	Hepatic lectin, N-terminal domain	Finn RD	anon	DOMO_DM01961	Family	\N	25.80	25.80	26.50	25.90	25.20	25.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.54	0.71	-4.77	5	128	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	27	0	61	131	1	121.20	43	48.84	CHANGED	pchpHLpNs.p-c+shcKGPPPoQPLLQRLCSssRLLLLSLuLSILLLVVVCVIGSQN.....SQLQEELRoLRETFSNFTSSTcsEVpALST........................pGGSVGcKlTSLESpLEKQQQDLKsDHSoLLhHVKQFssDLRoLoCQMAsL	......................................s...ptp....tG.....sPs.ps.h.hpR.LpShspL.LLuLuhslLLLV.llCVlGSQs............upLpc-LtsL+psFSNFous...ThsE.lpuLso........................pG.uu..lscKlpSLEupLEKppQ-Lps......cp..SplhhHlpphs.DL+.LsCQhs.h............................	0	4	4	10
+3182	PF05098	LEF-4		Late expression factor 4 (LEF-4)	Moxon SJ	anon	Pfam-B_6330 (release 7.7)	Family	Late expression factor 4 (LEF-4) is one of the Baculovirus late expression factor proteins. LEF-4 carries out all the enzymatic functions related to  mRNA capping [1].	20.20	20.20	20.60	22.10	17.80	20.00	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.78	0.70	-5.73	25	64	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	60	0	0	63	0	434.20	40	97.95	CHANGED	EpEISYTINaSQDLLYlIhcoYIsK+h.pht-cYsDllDpNsVRTRlhs................sphsSV+Kpslshp+hVah..sssslVPhVsRcshEpsssssspp......l+RllcspVY+...tpsslEIKFEHlYappNhsDphDuLhAsKQIsLaNLLpspsp..slspNSHLGSDEILAslRLEhEYc..sssstssLpphscllsch-.slstppNIoPhLPYTTLhNpIhYRKFpcE+.hl.....hs.t......t.ssssVh+WAlKLDGlRG+Gahs+s.hhll.hDDMQhFSGpl.......................................ss.FslNNlVuFQCEll-..pslYlTDlLpVFKYpYNNRsQYEsSh.psYsl-shsAlpslNhh........sssssphslssh.tst..hpl+FQpFacPPlphst....YsolPsDGFVVLDsphpYVKYKphKTlElEY-spsstFpslpGslpspshhss......Lp+ssIYEsllsc...ssIpVlKpRPDRLVPN	....................................................EpEISYoINhSQDL...LYhIhcoYIs.cph..phtpcYsDlhDpNslRTRl.s................sph.sSVpKpshphc+hVah..spsslVPhVpRcshEpshspsshp......l++llcspVY+......psplEIKFEHlYhppshh..Dp..hDuLhAsKQls....LhNLLpsssp.....sl.hpNSpLGSDEILAslRLEhEY-t...sssst.....shLpt..........hs....plltph-.slsptp.NIs..PhlsaTTl.NpIhYRKFtcEphl..hs.t...........t.sssslh+WAlKLDGlRG+Ghhsps....h.............h.............ll.hDDMQhFuupl.......................................ss..F.slNNl.VuFQCEllst.pphYlTDlLpVFKYpYNNRTQYEsSl.ssYslsshsAlpslNhh.........ppss.pplslpsh....s.thpl+FQpFacsPlp.st...........YsolPsDGaVVLssphpYVKYKhhKThElEYsstsshFpslsGslpshplhss......Lp+ssIYEsllsc...ssl.pVlKpRsDRlVPN....	0	0	0	0
+3183	PF04941	LEF-8		Late expression factor 8 (LEF-8)	Moxon SJ	anon	Pfam-B_5130 (release 7.6)	Family	Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to the  second largest subunit of prokaryotic DNA-directed RNA polymerase[1].	17.60	17.60	57.60	20.40	15.10	14.80	hmmbuild  -o /dev/null HMM SEED	748	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.32	0.70	-6.86	7	329	2012-10-01 19:23:01	2003-04-07 12:59:11	7	2	143	0	0	243	2	320.40	47	92.17	CHANGED	VlpDFscLYcplcsp.asLcahLsCss.puss.sol+hLQERKSYFCCAlc.sht+CVLHKCVlVVFGThLDtpFRss-......................sspsslpGTFMlDGRaLSFPNIMMNNNlLlHNFYDKLYu..KsCKRMFLYGNlD-EKpINRAIQLVYDctpDlLFARDVYApDYVVT--LNplLEhYLpsSGKWcPLsFLFcasptps.pLV-pIKhIMpt-INYSIDSLuNKIIYKHsYLlpLlY.cslLptYpt.htps.s...............s.sstsK++Ks.QolhasKEsKKIVDoIVNG+LIYsVSKTFSKQKKsF.N.QDNSSNNNIEIs.PsLKYRlGNEVlRITNDoMRQDMLKQchDFVKFlDSFFHGEMTVAGKKFFLCRsVRLPsVDYphVAc+FppLlppsLlhhss...........cp..........s-stDs.LLIAFNsRPTshpCcRsclspIhYthKRNhsPlElKlsssILFVNHHEGMlCIKKpV+lss....lpIssLLTPYEYHNppSllpshs...spl.EpDcVssLMSKLlQYYYpsahplFsTlPVPKLIVSLTNLKNAMPVhpYss.......t..lssLPlGNSVsVuPclhhNNKMFpLWTLVRDs+LMTAEDPYIPchsLPI+LYNNKlNKLKGKLshupp.psPhlKFh.pS.spsNhVslpsGpVLhhsGVlVSNsKIsWsaDGKRYKIETCpNKsaaVYKIYlYaRplcsQ+lE+lcuphsstsDsValKlslVTSTssLcGlKICGIHGQKGVhNsuEDLTEWMAEDG	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VAGKKFFLCRsspLPsVDYphVApKFp.LlppsLlhhss...........s......................................p.sp..cs.tllIAFNsRPThhpCp+.ssl.hIhYphKRNhsPlELKl..sspILFVNHHEGMlCIK+plpIps.....pspIssLLTPYEYHNppSllps.ssh....spl.E...p....D...cVpsLMSKLlQYYY+sahplFsThPVPKLIVSLTNLKNAMPVhpYpp..........p.hlssLPsGpSVsV.s.spIhhNsKMF+LWTLVRDs+LhT..............................................................................................................................................................................................	2	0	0	0
+3184	PF05094	LEF-9		Late expression factor 9 (LEF-9)	Moxon SJ	anon	Pfam-B_6326 (release 7.7)	Family	Late expression factor 9 (LEF-9) is one of the primary components of RNA polymerase produced by baculoviruses. LEF-9 is homologous to the largest beta-subunit of prokaryotic DNA-directed RNA polymerase [1].	19.50	19.50	22.60	22.50	17.20	15.60	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.64	0.70	-6.11	7	276	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	131	0	0	138	0	180.10	76	98.01	CHANGED	hlpFhsKsPocF-LLhDPscl.ssshFhshccF+hFLKslIsDLK+..KhNaFNSLl-QLIsVYp-ss.t+NEHTchLuRIlhATslVVT-LPSNVFLKKLKhNKFTDsIsYLILPNFILWDHNFllFLNKsFNSKH-suLVDISGslQKIKLTHGVIKDQlQsKNGYAGQaLYSTFLNTASFYANVQChNGsNEIlPP+sSlpRYYGRDVsNlRAWTTRHPNISQLSTQlScVhts....-s.sDWNVKVGLGhFsGANpDCDGDKcVITaLPpPNSLIDLECLLYGDPRasFICFDKNRLuFVSQQIYYLaKNlc+lEpLhcohPllhsLWppa+...stpFupRLEhLLRDssLlhSSNsSaLLappLsplIcsEEMVCuDcElhsLsGpFsslIcSGAKGStsLlcSTcpY+pTcssDlDTVupRAlTuLNSaIoSHNRVKlsGGDIYHNTsVLQNlYLKsshICYKsDshsluslCsLPSEFLFPEHLLDhF	....................................................................................................................................................................................................QaLYSTFLNTASFYANVQCLNGsNEIlPP+uSl+RYYGR.DVs...N..VRAWTTRHPNISQLSTQlScV+ps.......-s..TDWNVKVGLGhFsGANT.......................................................................................................................................................................................................................................................................	1	0	0	0
+3185	PF05150	Legionella_OMP		Legionella pneumophila major outer membrane protein precursor	Moxon SJ	anon	Pfam-B_6492 (release 7.7)	Family	This family consists of major outer membrane protein precursors from Legionella pneumophila.	20.90	20.90	21.20	22.60	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.87	0.70	-5.30	2	182	2012-10-03 17:14:37	2003-04-07 12:59:11	7	2	18	0	16	92	0	199.50	58	94.10	CHANGED	MhsLKKTssAVhALGSSAlFAGTMGPVCTPGNVTVPCERTAWDIGITALYLQPhYDADWGYNGFTpVGGWRpWHDVDhEWDWGFKLEGSYHFNTGNDINVNWYHhDssoDHWA.hsphHsYs.pWDAVNAELGQFVDFSANKKMRFHGGVQYAhIcsDVNRahNsFhhssFNSKFNGFGPRTGLDMNYVFGNGFGlYAKuAsAILVGTScFhDs...hsF.hGSKNAIVPElEhKLGADYTYAMAQGDlTLDVGYMWFNYFNAhHNTush.....suhETDFuASGPYIGLKYVGNV	..................................................................................................................................................YHa...D...sD.....o....D........+W.....s..........s...hu..............s.........h.............H...........s...........Y..s....N....+WDAVNAELG.QFVDFSANKKMRFHGGVQYARIEA..D......V.....N.....RY.........F.........N...N.....F......A....F.N.....G....F......N..S.....KFNGFGPRTGLDMNYVF.GN...GFGVYAKGA...AAILVGTSD.....F...Y.........D..G......................I........s......F......I......sGS..K..N....A..IVPELEAKLGADYTYA.M......A.QG.DL.T..LDVGYMWFNY...FNAM...H....N.T...uVh..........................................................................................................	2	10	10	15
+3186	PF03020	LEM		LEM domain	Bateman A	anon	[1]	Domain	The LEM domain is 50 residues long and is composed of two parallel alpha helices.  This domain is found in inner nuclear membrane proteins. It is called the LEM domain after LAP2 Swiss:Q62733, Emerin Swiss:P50402 and Man1.	20.50	20.50	20.50	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-7.94	0.72	-4.51	8	494	2012-10-03 03:04:30	2003-04-07 12:59:11	10	23	94	5	269	440	0	41.30	39	7.99	CHANGED	sDlspLSDsELpspLppYGlssGPIluoTR+LYEKKLhKLccp	...................ppLosp-LpppLhch.Gls.s.GPIs..soTRplYEKKL.h..ch................	0	66	87	174
+3187	PF04011	LemA		LemA family	Bateman A	anon	COG1704	Family	The members of this family are related to the LemA protein Swiss:P71452 [1]. LemA contains an amino terminal predicted transmembrane helix. It has been predicted that the small amino terminus is extracellular [1]. The exact molecular  function of this protein is uncertain.	21.00	21.00	21.00	22.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.03	0.71	-5.18	10	2668	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	2218	1	681	1981	523	183.70	35	94.86	CHANGED	hhsslhlhllllllslhsssuYNsllst-cslcsAWSplpsphQRRsDLIPNLVETVKGYAuaE+cTLccVsEARA+ss........thpcspshp+hppApsELouuLuRLlllsEsYPsLKANpsFhpLpspLcGTENRIAluRpcYNcuVpcYNspl+pFPollsA+haG..F+stshFpss..EutpssPKVcF	...........................................................................hh....lllh.l..l.l.l.l..l.s.h..h.s..h....s.s.Y..NsL...lp...hcppscpuWup.....l-sQh.pRRsDLlP..NL........Vp..TVKGYAp.......a..E.p....p.....sL.p..p.....VscA..Rspss...................................s..s...p..s...hpp..ht....p....A..p.s.p.L.....osu......L...u..p..L.h....slsE....s.YP.-.LKAsps..FhpLQ...ppLp.sTEN+IuhuRphYNssVppYNspl.c.p..FP.s.s.l.l.A.t.h.hu.......a.p.t.t.s.hapss....tt.t...p.p..s.PpVpF.............................................	0	226	462	587
+3188	PF02998	Lentiviral_Tat		Lentiviral Tat protein	Bateman A	anon	Pfam-B_1519 (release 6.4)	Family	This family contains retroviral transactivating (Tat) proteins [1,2], from a variety of Lentiviruses.	19.80	19.80	19.90	21.70	18.20	19.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.07	0.72	-4.16	7	50	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	15	0	0	41	0	58.70	81	96.23	CHANGED	.EEhPpRR.stscEhs.h..a.cEh-sWpasS.RVPGEhLQRWLAMLpsuR.R++VlREMQKWMW+aPKAPVIRsCGCRLCNPGWGo	.....Ep.s.t..ht..th..h..h.c-h-sWphhS.RsstphLQhWLAMLp.tp.RtpVhpEhQhhhWh..tA.lhRsCGCRLCNPGWGT.	1	0	0	0
+3189	PF02024	Leptin		Leptin	Bateman A	anon	PSI-blast P41159	Domain	\N	25.00	25.00	25.40	25.00	24.90	23.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.02	0.71	-4.53	7	218	2012-10-02 01:28:15	2003-04-07 12:59:11	10	1	124	1	24	189	0	120.30	70	91.48	CHANGED	VPIpKVQDDTKTLIKTIVTRINDISHTQSVSSKQRVTGLDFIPGLHPlLSLSKMDQTLAlYQQILTSLPSRNVlQISNDLENLRDLLHLLAhSKSCsLPpspGLEohESLGGVLEASLYSTEVVALSRLQGSLQDMLpQLDLSPGC	...................................lpsDoKsLlK....TIlsRIsDIS+hQSVSSKQRVTG...LD.F...IP...GL...H...PlLSLSKMDQTLAlYQQILTSLPS.RNVlQISNDLENLRDLLHLLAsSKSCsLPpsp..uLc..oL-SLssVLE...ASLYSTE.VVALSRLQuuLQ-hL.pLDhuPtC....	0	1	3	6
+3190	PF03588	Leu_Phe_trans		Leucyl/phenylalanyl-tRNA protein transferase	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.40	22.40	23.00	22.60	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.97	0.71	-5.13	9	2004	2012-10-02 22:59:21	2003-04-07 12:59:11	9	3	1956	17	506	1355	651	170.90	46	73.57	CHANGED	ssspLltAYppGlFPhhpp..spslhWasP-sRullhs-.plHls+slp+sl+pshapVphstsFtsVI-uCAsst...tpsTWIspthpcsYhpLHphG..aAHSlEsWpscc.....LVGGlYGlulGplFaGESMFSptssASKlAhlpLschLcstuatLlDsQh.spHLcphGApclsR	..........................................s.stRLLtAYppGIFPWass........spP..ll...WWS.....P-.....PRuVL.....h..Pc.....ph...H.lS....+Sh++....h....h....+........p.........s..............a....clolspsFspVIcu.CAss....+..................p.........puTWIscplhcA..YpcL....HchG............aAHSlElW..p.s....s..c.......................LVGGlYGVul..G..p...lFhGESMFS....c...t....p....s...A...SK..sALhh.Ls.p.c.htpp..G...h..pLIDCQ.h.h.s.sHL....tS.LGAp-IsR.....................	0	155	324	426
+3191	PF01819	Levi_coat		Levivirus coat protein	Bateman A	anon	PSI-BLAST 2ms2	Domain	The Levivirus coat protein forms the bacteriophage coat that encapsidates the viral RNA.  180 copies of this protein form the virion shell. The MS2 bacteriophage coat protein controls two distinct processes: sequence-specific RNA encapsidation and repression of replicase translation-by binding to an RNA stem-loop structure of 19 nucleotides containing the initiation codon of the replicase gene. The binding of a coat protein dimer to this hairpin shuts off synthesis of the viral replicase, switching the viral replication cycle to virion assembly rather than continued replication [2].	19.40	19.40	21.40	21.00	19.20	15.80	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.25	0.71	-4.56	5	151	2009-09-11 00:12:26	2003-04-07 12:59:11	12	1	26	164	0	161	0	102.30	51	72.02	CHANGED	ApLpslVLsspGuTGNsTlsls...VNssNGVAEllpusuVPutEpRVTlSVRQoSssR+KYslKlcVPslsoQTVNGlssPuVsRpuYssV-LoastaSTscER.slIsppLAALLKDshlIcusIssNsGa	..uphpphsLst.GtsGp.Tls.....ss.sNGVuth.ps.ss.u.th+VThShttsutpp+paplplcl.pssspTssGsp.PssshpuYhsh-LTIPIaATssDs.tLIsKuhtGLLKDGsPIsusIusNSGh...	0	0	0	0
+3192	PF01726	LexA_DNA_bind		LexA DNA binding domain	Bashton M, Bateman A	anon	Pfam-B_1975 (release 4.1)	Domain	This is the DNA binding domain of the LexA SOS regulon  repressor which prevents expression of DNA repair proteins. The aligned region contains a variant form of the helix-turn-helix DNA  binding motif [1]. This domain is found associated with Pfam:PF00717 the auto-proteolytic  domain of LexA EC:3.4.21.88.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.96	0.72	-4.41	9	3433	2012-10-04 14:01:12	2003-04-07 12:59:11	11	9	3000	10	740	2157	1670	64.30	40	31.34	CHANGED	MpsLTtRQp-lLchI+splpppGaPPohtEIuptlGhpSssuspcHLcALp+KGhI-hsPGpsRu	.............................tLTt.RQpcll-hI+ppl.p.ppGhP..P.ohpEIuptlGh.....p.SssusccHLpsLp.+K...GhIchssspsRu............	0	239	478	621
+3193	PF01790	LGT		Prolipoprotein diacylglyceryl transferase	Bateman A	anon	Prosite	Family	\N	24.90	24.90	24.90	24.90	24.70	24.80	hmmbuild  -o /dev/null --hand HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.67	0.70	-5.44	67	5002	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	4357	0	1133	3460	3019	251.80	31	88.04	CHANGED	hsPlhhplG.P..l.......sl+W.....YGlhhhhGhllAhhl.ut+psppt...........shst-pltDhlhauhhusllGuRlhYV......l...aph......shY.....hpp.........P.hplh...plWcG........GhuhHGGllGshluhhla............................s+ppp..ls.....hhphsDhlAPslslG.uhGRlGNFhN.tElaG+.....s....ss........athl.P............................................t....................th.......................h.hh.hHP.......o.LYEuhhp.lllFllLhhhh....++..hthh.GtlhuhallhYulhR.hhlEhhRp..sshh............hhhh...............lphuQlLSl.hllhGlhhhlhtp	................................................................................................sPlhhpl.G..P....l..........sl+W.....YGlhhlsG.hlh.Ahhl...up..+..c..hp+t..................................sh.s..p...-...p.l..-...ll.h...h...u.h.lu.s...ll.GuRlhYV......l......aph............................shY...............hps..................P....hp.lh..........p.lW.pG............................Gh.....uh.H.GGll.G...shls..hhl.a............................................................s.+..+.p.p.....hs.......hh.p.hhDhl.APslslu.uhGRh.GNF...hN...tE.haGc............ss......shs...................huhlhs.........................................................................................................thshh..hHP....o..LYEuhhp.llhFll..L.h...h.ht....................++.................h............t......G....tlhu....lalhhYuhh...R.hhl.E.hh.Rp.ss.h..........hhhh.............................lphuQl..LS.ls..h..l.lh.Glhhhlh..t......................................................	0	398	772	979
+3194	PF00556	LHC		Antenna complex alpha/beta subunit	Bateman A	anon	SCOP	Domain	\N	20.50	20.50	20.80	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.65	0.72	-4.11	28	509	2009-09-11 14:13:18	2003-04-07 12:59:11	15	1	110	48	157	438	71	38.60	27	65.17	CHANGED	ptchhclac.hhsh...hhhhsllAllsHhllhs...tpsWls	.................chhplas.hhsh...hshhhslAllsHhllhs.....hpsWl.........	1	40	76	92
+3195	PF04991	LicD		LicD family	Moxon SJ, Bateman A	anon	Pfam-B_5278 (release 7.6)	Domain	The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent [1]. These proteins are part of the nucleotidyltransferase superfamily [2].	22.60	22.60	22.90	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.53	0.71	-4.22	142	2479	2012-10-02 22:47:23	2003-04-07 12:59:11	8	25	1053	0	634	1816	209	187.40	23	55.89	CHANGED	sccpslphalstGoLLGhh+csshlPWDsDlDl.tMshc-hp+.Ltp.hhsp.......h.............................................phlh-ssohhhpptptstp.............csGla.IDIhsl....s.hs................................................................................................ht.ttpphht...................ppc.hhshspl.Plpps.FEGh..hhlPsshcphLpptYG	..........................................sccpslp.aalstGTLLGAlR.c.p.G...h.IPWDDDlDl..sh.R.c.D..Y...p....+...hhp..hhpp.....h.t.................................h.h.t.............h.................................tplhc.t.ss.hhhpp..t..ht.h........................................pulh..lDlhsh........Dhhsp........................h....................................................................................................................................................h..................h.....p.th.p..tp..............................hshtp.s.phhs.h......................pp..hh.sh.p...ht......hh...h.FEsh....h.hPtpacphLpphYG....................................................................................................................................................................................................	0	221	392	560
+3196	PF01291	LIF_OSM		LIF / OSM family	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.50	20.60	20.30	20.30	hmmbuild  --amino -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.17	0.71	-4.31	5	88	2012-10-02 01:28:15	2003-04-07 12:59:11	12	1	43	8	39	131	0	150.60	44	76.61	CHANGED	sLLsQLQNQssLhssou.oLL-PYI+lQGLssP.sLcctCsp+ssDFP.SE-sLpcLoRhsFLpTlsATLGslLppLocLQQcLscsAch...........KLssAccNlRGLtNNVaCMApLLp+Su...hsEPTpss.G...PsPsTossDsFQRKltGCpFLtGYHRFMuoVGQVF	........................................................LhsQlppQhs.lp.sou.sLh..Yhpu.QGpsh.......P.....s...L...c.....c...h.C.s...s...sss.FP.....c...s.s...hsphs+..h..st..Lh...p...l.hshLuss...L...sslTc....QchLssssh............LhpKLpsstsslRGLhsNlhC.hlsph.apsu....phsss..........sPsT.sspDsFQ+KhhGCplLtpY+phhuslupsF................	0	2	2	8
+3197	PF00549	Ligase_CoA	ligase-CoA; 	CoA-ligase	Bateman A	anon	SCOP	Domain	This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilise ATP others use GTP.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.80	0.71	-4.62	20	8836	2012-10-02 00:59:22	2003-04-07 12:59:11	14	29	3569	68	2607	5875	4883	125.00	32	32.56	CHANGED	lhsGGTLAhEshtllpts....................supstshlDlGsDsas.........ssphtctlphhssDs.cVpsILlslhlGhGss-t.AuullpAhccsp.......tplPlVuplsGTssD...t.h..pptphLpcuGltlhsusspAstsstsl	...........................hspuusLshpshc.lpth...............................G.hs....ushl..slGGssh....................spphh-slchhhs..Ds...ps..c.....uIlh.h.hG..............sps-t..As.u.h.l.p....A.hppht..........................thPlVshl..t...G..ssAs..............tttt..hl.h....s...u...G.h....s.hsssc.hs.tstt..h..................................	0	824	1565	2169
+3198	PF00412	LIM		LIM domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family represents two copies of the LIM structural domain.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.69	0.72	-3.90	38	16362	2009-01-15 18:05:59	2003-04-07 12:59:11	17	199	437	88	8615	14824	48	57.20	26	24.59	CHANGED	CuuCsctIh....sp.hs..uhscsaH.pCFpCspCpp.Lssss....ha.p-u..c....lYC+p.cahcth	................................CstCsp.Ih...................stt.h.....h.................u..........h.......s..........p.....t...a..H.....p..CF......p..............C.........s......p...C.........p..p..t....L....s..sts..........ah....p.....cs....p...................haCpp..sa.t..h....................................	0	2081	3129	5636
+3199	PF01803	LIM_bind		LIM-domain binding protein	Bashton M, Bateman A	anon	Pfam-B_1352 (release 4.2)	Family	The LIM-domain binding protein, binds to the LIM domain Pfam:PF00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) Swiss:P70662 is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons [4]. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development [2]. The Drosophila protein Chip Swiss:O18353 is required for segmentation and activity of a remote wing margin enhancer [1]. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development [1]. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions [1].	19.80	19.80	19.80	20.60	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.25	0.70	-5.26	42	464	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	238	0	283	431	0	206.00	32	39.09	CHANGED	hhRLhpasccL.....ssh.......................sppssltaWppFVpcFFs.........ssushRhslpttss.............................................K.pFElshshlPRaa.pohFsoGlpchphhl.ptsp-pshssushhl-ss+sshhhhatsss..........................plsscGpL+shF.................s.phKIchh-hsspsHpEhl.sRshlt.hht...................t.....t.chspspphp...tt............l.......pslsp.hGlspsshphLclu-llspMpsLhsapppps.luPh-uL+p	...................................................t.hRlhph.c+l.....pph........................sppss..aWctFss-FFp.........ssAhhphshshtsss..............................................K.pa...pIstsllPRaF.pohF...........cuGlp-hhhhl....thp.c..p.s....hts.......s.....tlhl-sspsshlo.ascsh..........................pVs..s-GpLhlpF.........................cs.h+IcsWcFs.............h+pa...cEhl.PRshlt.tsp..................................-.phhsp.ht............................................................................pslsc.hGloptslp.hL.............cls.llpsMp-Lhshp+phs...luPh-sL+....................................	0	75	140	221
+3200	PF00538	Linker_histone	linker_histone; 	linker histone H1 and H5 family	Bateman A	anon	Arne Eloffson	Domain	Linker histone H1 is an essential component of chromatin structure. H1  links nucleosomes into higher order structures Histone H1 is replaced  by histone H5 in some cell types.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.35	0.72	-3.88	20	1947	2009-01-15 18:05:59	2003-04-07 12:59:11	14	46	377	9	991	1945	10	71.20	32	23.85	CHANGED	uHPsht-MIssAIpuLKERpGSSh.AIpKYIps.sY.chslss..hshhl+puLK+sVpsGpLhpsK......GusGSF+Luc	.......................Pshtphlh....pAI.p...s.....L..c..E...+...s.G..o...ShtAIpKalps..pa...p....p..h...s.s.............h.t...ph.l+tsLKph.VspGpLhpsK..........G...sGoa+Ls..........................	0	258	429	691
+3201	PF04454	Linocin_M18		Encapsulating protein for peroxidase	Waterfield DI, Finn RD	anon	COG1659	Family	The Linocin_M18 is found in eubacteria and archaea [1,2]. These proteins, referred to as encapsulins, form nanocompartments within the bacterium which contain ferritin-like proteins or peroxidases, enzymes involved in oxidative-stress response. These enzymes are targeted to the interior of encapsulins via unique C-terminal extensions [3].	24.30	24.30	24.30	24.40	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.20	0.70	-5.48	59	323	2012-10-03 06:22:39	2003-04-07 12:59:11	7	3	313	13	123	298	12	246.00	34	89.18	CHANGED	Ms..LtRc.APlostsWppI..-cpstpsh+ppLsuRRhl-ltGPhGhshsulshsclpthps.ttt............lpsthRpshPlsplphsFpLstp-l-sscRsutshDhssltcAAcplAhtEDchIFpGhstsultGlhsssupttlpls..ssstshhpslscAlspLpps.....GhsG.PYsLlluschYstLtchtsp.G.hs.hc+lccll.susllhuPslcs..ullloscsush-LtlGpDlulGYhupsspshphhlhEohs	.............................................................................Ms.LhR-LAPlopsuWtpI..-pcsscoh++plu......GRRlVDVssPh..G.shuuVssG+ltplpsssps............Vtsp.hRpstPLlcL+VsFsLsRp-lDsl-RGupD.sDhpslc-AAcclAh.s.EDcsIF.........cGa....s.........sAu.....I....p.....Glpsu....su.s.st....l........s......L........s............pc..s..pshscslupAlspL+..h..u........GlsG...PYullLus-s..Ysplsc.s...s...-p....G.YPlhc+lp+ll.s.....GcIlhuPulcG..AhllosRGGDa-LplGpDluIGYhuHcsp.sVpLalpEohT..............................	0	44	82	104
+3202	PF03583	LIP		Secretory lipase 	Finn RD	anon	Pfam-B_3085 (release 7.0)	Family	These lipases are expressed and secreted during the infection cycle of these pathogens.  In particular, C. albicans has  a large number of different lipases, possibly reflecting broad  lipolytic activity, which may contribute to the persistence and  virulence of C. albicans in human tissue [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.75	0.70	-5.21	12	1102	2012-10-03 11:45:05	2003-04-07 12:59:11	9	8	480	0	414	1391	144	260.10	24	62.70	CHANGED	hQhuusho..Tl.TQh-hhhlsshLppGaaVVlPDYEGPKo.....TFsVGRQSG.pAsLDSIRAsL+otphoGlssDu+VulWGYSGGulAouWAAtLQPpYAPELpps.LlGAAlGuhssNlTuhscusDGolFuGlls.uLsGlANEYP-h+phlhpclsctup.shcphsptClusulhcashpphhTG.p+sFppGhslLcs..sls+hlp-NtL.hhspphlPplPlhlYHGshDpIlPItsscthhpsWCshGhsslEFuEDhhsG.......HhsEshsGAPAAloWlpsRFsGcsslpG	.........................................................................................................................h...................p..h..l...sth.L..s.pGasVs.ssD.....Y....p...G......ss..............sah.s.....s.....p.....t...t.u..tu.....l..LDu.lR.A....uhp...h...t..t............s.l......s........s........s......l...slh..GaStG.G...h.A.u....h....h.A...A....p....h.t.....s.....s.......Y...........A....P....ELs........lh...G.s...s.h...Gu.s..s.........s....s.....l.....t..........t.....h.......h........p..........t..........h........s.........s..........s............h..............h..........s......G.......h..............h..............s..........h.......s.....l...h........G.l........t....p..t...a...P.....p...l...p..........l...p...p.hl.ss.p..u....p...t..h...h....p...p....h.p...p....t..C...h...s..t...h...h..h.t...h..........s.................h...t...p...h.......................................h.........t..s........p.h..h...t....p..............htph.h...p.p..p.....th........................p....h...hP.....s......h....Plhl....hp................u................h.t................D....t....l.....l.s....h.t.s.s.pt.h.h.p...p.ass.......t.........G...............ss.l.p........a..t..t.............h..s..t..........Hh....h........s....h...s..........s...h...t.altthhtt..................................................................................................................................................................................	1	83	269	368
+3203	PF03279	Lip_A_acyltrans		Bacterial lipid A biosynthesis acyltransferase	Mifsud W	anon	Pfam-B_1803 (release 6.5)	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.61	0.70	-5.54	13	5234	2012-10-02 00:16:30	2003-04-07 12:59:11	8	10	2565	0	1047	3702	3078	280.50	24	90.64	CHANGED	phpFphphhhPpYahs.WlGluhlhllshhPhshhctlsstlGthht..hhhpctpcpA+pNLshsFP.-ho-sE+-pIlcpshpohuhslhEhuplshhs...ccclpcphc..............htGLEplcphhppscullLhssHthsh-luuhhlsppts..shushtppptN.hlsalhsphRpphstclls+pss........lcshlcuL+pGc.slhhlsDpDhssc.ulhVsFFus.sssssssuhLuh+os..AsllPlhshhpscs...ttashplpPshchp.pt....DspplspthNchlEphItspPEQYhWlp+paKo	...............................................................................................................h...................h.h.h....s.h..h.h....h...l.s.hl.Ph..hh..hh.l.u...t.tl.Gthsh......hh..h..p..p..pt...c.h.s..p..t...N.L.p.h.s...F......P......p.......h.o..p........t........-........+......ctll.t.c....a.psh.u.h.s.h.h....Eh.s.h.h.h.h.hs........s.p.c.l.p.p...h...h.c...................hp.G..h..-...t...l....c..p..h....t..t..p..s..c..u..ll.l.l.s.sHhhs..hE....l....s....u...h...h....h....u....t.....p....t........th...u...s...h...h...............p......p........N...shh..-....h..l.h.....p......p....s..R..t....+......h.....s....t.....p....h.....l..s...+......p..s.....................l+...s.hl.....p...s....L.....+.....p....G....p...hlh.h..h..s.D........p...........D...h.....u..........c.......t....u...l.a....l...s...FF..u....h.......s...s...s...s.s.s...s.s...h.l.h.p...ths....As.l.l.s.h.h.......s.....h.....+..p..scs....................ta...p......l......h....l.....t.....P...s.....h....c....s......s..t.t...........Dt..p....p....s....s...t...h....h...N....c...hl...Ep...h.ltttP-QY.h.Wha+RaKp.................................................................................	1	274	606	844
+3204	PF00151	Lipase	lipase; 	Lipase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.18	0.70	-5.22	16	1975	2012-10-03 11:45:05	2003-04-07 12:59:11	14	31	255	16	1058	2017	14	262.60	27	71.62	CHANGED	ppVshtplss.upp.shss.shpcsh+.h..psPpphc..s+FLLapscs....shQhh..ucssTlcsspFsss+hTphIIHGasscG......................pEsWlschscshhph..cssNsIsVDWtsuupshYs.AstNl+lVGtElAthlshLpsphsas.psVHlIGaSLGAHVAGtAG+phsG....plGRITGLDPAcPhFpsssp.sRLsPuDApFVDsIHTsst.....LGhGhoQpVGHlDFFPNGGpp.hPGCppsl...........th...hhtCsHhRSh+Yas-Slh..Nsc.sFsuasCuShppFppscCasC.tt...pCspMGah.hscashppttlptcaaLpTsspSsF	.....................................................................................................................................................................................................phhlh...t....tt........t......................h......................p.....s...h..t..t..s..t...a.....s.p.p.shhllHGatsss.................................pp.hh..p.h.h.p...s.hhp...t.......t.s..h.N.lls..lDW......t.....t......h.u.........p........t.........h.........Y..................u..s.t.s..s.p..h..l.Gt..pluph..lphL......t......p..h...s........h.s...h.....p..p.......lHlIG.aSL.GAHl.uG..huGph.hpt..........pl..s..R...IT..............G..L.....D...PAt........P.h....F.p..........t......s........s.........t..............+.....Ls...s.D.A.pFVD....lIHTss...............h.....sh...G.h....pshG+hDF.YP.N....G....G.p...QP.GC...t.........................................................h...CsH.Ruhphah-Sl........p.p..sh..hu..h...C..s..s.h.p.t.......h....t..s....C..hs......................tps...hG......h.....t......t..............................................hhh.stt..sa..................................................................................	1	307	390	782
+3205	PF01674	Lipase_2		Lipase (class 2)	Bashton M, Bateman A	anon	Pfam-B_968 (release 4.1)	Family	This family consists of hypothetical C. elegans proteins and lipases. Lipases or triacylglycerol acylhydrolases hydrolyse ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol  and free fatty acids [1]. Swiss:P37957 is a extracellular lipase from B. subtilis 168 [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.38	0.70	-5.03	15	461	2012-10-03 11:45:05	2003-04-07 12:59:11	13	7	242	42	222	809	70	188.40	27	62.77	CHANGED	psPllhlHGsu........s.tussapphhphFhccG.YssuplYATTaGcssp.sshppsp....pCpal.pplRchl.AVttYTGs.+VDIlAaShGsPIARKAIlGG..pCs.DssssLGssLsppVcTFlulu..............GsNtGhssC.u............hh..hC.NhpsGLh....C....................tScFLpDINsps+h-.uptlaoIaSpsD-llt....tphsCG+pouhIPsucshp.YcthsHppshppTsthQhp	...............................................................pPV.VhlHGsu...................s.sh.hs.a.st.h.tsh...Lts.....p.G...ast..........l..auh.s..a...s..st..st...........s.....hpsst.................h.....s....t...............p........l.s.pF...l-....p.V...L...t..t...TG....A.pKVD...lluHS.G.u.s.l.sRhY..l..c...hh.......sus...c....p....h.t....tl.s..s.......h.s.p.h.t.s.......h.l.u.l.t.........................................u...s...s.h.sh..s.h..................h..hs..s....th....................................................................................Stal.......ppl..N....s....s...s.....h.....u..thhslh.ophDphlh.....................................................................................................................................................................................................................................	0	88	142	214
+3206	PF03280	Lipase_chap		Proteobacterial lipase chaperone protein	Mifsud W	anon	Pfam-B_4313 (release 6.5)	Family	\N	21.10	21.10	21.30	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.31	0.71	-4.78	34	328	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	282	2	63	274	15	184.30	29	59.61	CHANGED	sLhppYlsY+pALssLp..............tshtsphsl.sslpphhpphtsLpppaFuts.tpuhFGsEpphpphslc+lpItpsssLospp+tptlttLpspLPsslppu.ppptpt.pcltpttpth.tpG.ssspplhtht.tphlGs-uApRLtplcppctsWcp+hssYhppRspI...ssslspsp+pttlspLRpptF.sssEth	..........................sLappYltY+psLupLp...................sttssthsh.sthpphhpphtsLpt+hFu.sttpshFupEpthpphsLc+h.....c.Ihpst.sLsst.p+tptlp.t.Lh.....tp..h.Ppthppu.....p.........tp.sph.tpLpp....tttt......h..ttt........uss..pphhttR...sthl.G...s-.uApRLtpL-ppcssapp+hssYhtp...RspI.......ps..tLS....sp....-+ptpIpp.LRpppF.sspph....................................................	0	9	23	45
+3207	PF00657	Lipase_GDSL		GDSL-like Lipase/Acylhydrolase	Bateman A, Mistry J, Molgaard A	anon	Prosite & Pfam-B_543 (Release 7.5)	Family	\N	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.79	0.70	-4.54	65	4517	2012-10-02 11:02:24	2003-04-07 12:59:11	17	78	1181	20	2407	11569	2075	269.30	15	70.51	CHANGED	lhshGDSloss........................stsh.tshtshl.t........................shshshhstuhuGps...........................................................................................t.hht.h.ttsthsssllhlhlGsNDh..........................................tts.ptshsphhsplpphlptlp..ptssp.....shhhhsts....................................h.t.tthpphsttasphlpcls.......................tthphshhDhaphh.ph.............................................................................hhhDsh........Hsospupphhuctl	............................................................................................................................................................................................................................................................................................hhsFGDSlsDs...............................................................................................s......t..p.....h...............................................................s......h.s...h...s...h.......s...h....s.........s..G.th..s.ssthh...........................................................................................................................................................................................................hht.....h...h...t......t........t....s...t...t........h....h.......s.....p....s..l........h.....h..l......h.G.s.N..Dhh..................................................................................................t.....p...t....h..h.....s...t....h....h....s....p....h....p........p....h.......l....p....p............L....h.....ph.....G..u+..........................p..h......h.l.h.shs...shs...........................................................................h......................................t.....t...t.......t....s.....h.p....t....h...s....p......h....s.......t...h..a.....N..p...t...l...p.phl...tt........................................ht.t..h..............sh.p.h...h..h....h.....D...h..a....s...h.h......p.h.......h.tp.stthsh......sh...............................................................................................................................h.s.ppah...h.h.....D.s.h.................H.opt.spphlup..h...............................................................................................................................................................................................................................................	0	460	1376	1961
+3208	PF00061	Lipocalin	lipocalin; 	Lipocalin / cytosolic fatty-acid binding protein family	Eddy SR	anon	Prosite and HMM_iterative_training	Domain	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.71	0.71	-4.21	156	2221	2012-10-03 08:47:39	2003-04-07 12:59:11	18	19	289	489	974	3261	80	128.60	17	76.93	CHANGED	sG.pWhhhuhts.....hcphhpthssshtphp...sssshthpthp...h........pss.p..sppts.shcps..ppshphshp.......tssp...phpsl.ph-hpshhlhhtptp....tt.pshhtplhscs.clstph....h.th......shspss.hhph.pps	.................................................................................................G.pWh.hhs...ts......hpchh.p.t.h...s....l.s.h.t.thp.....h...sssshss.hhht.......h......................................pss.p........hpph...s......s.h..c..ss......ph..s..h...c..hshph.t.........hsssp.........chp...sl...sh.-h.t...s..hhl.h.hpptp......u..p..p..sh..htpl................s....cs...p.h....ph..................shtt..hh.....................................................................	0	111	187	385
+3209	PF00820	Lipoprotein_1		Borrelia lipoprotein	Bateman A	anon	Pfam-B_1321 (release 2.1)	Family	This family of lipoproteins is found in Borrelia spirochetes.  The function of these proteins is uncertain.	25.00	25.00	40.00	25.00	18.30	20.40	hmmbuild  --amino -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.71	0.70	-5.30	7	599	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	62	32	2	611	0	175.20	69	94.88	CHANGED	sSShDEKsusphDLPuthc..V........hVSKEKsKDGKYsLcAhVDplELKGTSDKNNGSG.sLEG.KsDKSKsKLoIu-DLsphThEhacpss.ThVS+KVspKDtS.TEEp..h.cpGcLSpKplTRsNGTpLEYo-Mps-.susKAhEsLKN.lphEGsLsus.KTTLplpEGTVTLo+EIsKsGclplhLsDo.ootuoKKTusWsspTsTLTISsNSKKTKpLVFpp-sTITVQpYDSAG.TsLEGoAsEIKsL-cLKsALK	........................................tsp.DLPGtMc..V........LVSKEKsKDGKYsLhATVDKlELKGTSDKNNGSG.sLEGsKsDKSKVKLTIoDDLupTThElFKEDGpTLVS+KVs.KDKSS...TEEp..FNcKGc.lSEKhlsRuNGT+LEYTphpss.ssuK.ApEsLKs.hhL..EGsl.sst.csp.l..l.p.puTVsh........................................................................................................	0	2	2	2
+3210	PF03202	Lipoprotein_10		Putative mycoplasma lipoprotein, C-terminal region	Mifsud W	anon	Pfam-B_2205 (release 6.5)	Family	\N	22.40	22.40	22.40	22.70	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.96	0.71	-4.14	12	80	2009-09-11 23:29:08	2003-04-07 12:59:11	8	3	32	0	36	80	0	128.20	30	19.30	CHANGED	sITQGPNlIGIHANEKENtETpKFVNWFLNsp.oWcspp.sptpppppp....pTsApaFAESASYILPLKEhFcps.....ptctspsp...........................t...NoascKAL-lFpplucsplluYSDPSDFRSGKFRDuIGusFN.AsVsSKs	.........................sQGPsLIGIHu.N-KE.-ptTpcFVpWh.........l.sp...ppsapt.p..t.......p.....p.pp.............tTsupahscsuSYlhPhKphhsps.....p....ttp.............................tpNhhhcps.h.chhp.p.h..p..p..s..p..hs.a.p.-P.ushpSupFRcslsosassh.s........................................................................	0	23	34	34
+3211	PF03260	Lipoprotein_11		Lepidopteran low molecular weight (30 kD) lipoprotein	Mifsud W	anon	Pfam-B_4108 (release 6.5)	Family	\N	25.00	25.00	28.90	45.30	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.77	0.70	-5.38	6	84	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	4	2	52	54	0	234.40	40	85.01	CHANGED	VhusCVlAuSAuls-hsss.....sc.LE-cLYNSllsGDYDoAVpKShEhpcQuKGsIIpssVNpLIcDupRNTMEYAYpLWltsG+-IVKcYFPlpFRlIhuEssVKLI.KRDNLALKLGsssssss-RIAYGDucDKoS-pVSWKFIsLWENNRVYFKIhNTccsQYLKLu..sssssssD+hlYGssoADTaRcQWYLQPAKY-NDVLFFIYNREYNcALcLuRsV-usGDRpAaGHsGcVtG.P-lFuWhIssF	.........................................p........sp.lp-pLYNsllsuDYDpAVppohpl.ppspup.lIpplVscLIcstcpNsh-aAYKLW..h.ssup-IV+chFPhpFRLIhspp.hlKlI.+p.shALcLussss.ts-RhAaGDupDK..TS.cVSWKhlslW.ENN+VYFKIhNschspYLKLu..ssssssGD+hsaGussu-opRcpWaLpPsc..a-sclLFaIhNREYsp.uLKLupsV-ssGDRhsaGpsGpVsGpP-hauWhIps......	0	52	52	52
+3212	PF03330	DPBB_1	Lipoprotein_13;	Rare lipoprotein A (RlpA)-like double-psi beta-barrel	Mifsud W, Studholme DJ	anon	Pfam-B_3255 (release 6.5)	Domain	Rare lipoprotein A (RlpA) contains a conserved region that has the  double-psi beta-barrel (DPBB) fold [3,4]. The function of RlpA is not well understood, but it has been shown to act as a prc mutant suppressor in Escherichia coli [1]. The DPBB fold is often an enzymatic domain. The members of this family are quite diverse, and if catalytic this family may contain several different functions. Another example of this domain is found in the N terminus of pollen allergen.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.87	0.72	-3.98	127	5162	2012-10-01 21:39:58	2003-04-07 12:59:11	13	43	2566	5	1785	4300	468	87.00	26	33.33	CHANGED	ssssssuha......ssu.....susGpsaphps..sspts....................sps........pulsVplsDhsP................ssppthDLStsAatpluhh.........ps.Gl.ls.Vpa	.......................................................................su.uuhY.......sst............susGp..s..a.p..hp.s.hsuAcps..............................................hsp..s+s........s....t+ollV..plsD+sPh...........................ss.s.c.h.lDLSt.sAhp.p.l.uhh.........ps.Ghs..Vp.............................	1	492	1115	1484
+3214	PF03640	Lipoprotein_15		Secreted repeat of unknown function	Yeats C	anon	Yeats C	Repeat	This family occurs as tandem repeats in a set of lipoproteins. The alignment contains a Y-X4-D motif.	21.10	21.10	23.90	21.30	18.80	21.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.49	0.72	-4.52	22	995	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	347	0	428	953	61	45.30	32	56.64	CHANGED	hshlppcD...Gsh.hshcGhsLYpFs+Dpt.G..suss.hss...sWssht	.................htptc.....Gp.h.hs.hpGhsLYpFs+D.s.t.sGthpus...s.sss...sW.sh.....................	1	119	258	343
+3215	PF04791	LMBR1		LMBR1-like membrane protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_6189 (release 7.5)	Family	Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought [1]. Vertebrate members of this family may play a role in limb development [3]. A member of this family has been shown to be a lipocalin membrane receptor [2]	26.60	26.60	27.00	27.10	26.30	26.50	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.54	0.70	-5.91	9	832	2009-01-15 18:05:59	2003-04-07 12:59:11	11	11	260	0	554	801	5	364.40	17	72.65	CHANGED	lhhlLhhllalhshhlls+ap+hsct............................tplshhlsshsLuluhsulhLLPhslhu.............sphhh.hspsh...........htalssSlltuLWphlalhSsl.lallhPFshhFhESpsFssppKt..lpuplhEshshhhLhulllLsllhVhusl..........................h.................uhhshhphahshlhSssohhGllLLllhsshGlsch.sshhphhl+....................................spllpDspcph.p.shtpupls+clpp......t.....thtt...t...u.tt.hh..pt.hts.tph..t......................................................................................................................................................ssthphshshshshhsLLhhsshplLhVstshlplllshstlshhs.......ttsslthsohohhGhhGsslphllIhYLhhoohsGhaph.h....hphht.chccTshsphlhNsuhlLl.sSsLPlh.phlGlspaDhhssau...................slphlG.hhhlhlaplhFshloshsL	........................................................................................h.....hhhh.hh..hs....h....h..hlh.ha..tp...t.pt...................................hh.shhh.shhshhhshh.hlh.llPhslh........................................................................................................tt.......................................h.th....h..st.....t....h..h..h.......h.......W...........h.......h.......ahhs.hhhh.......hl..lPhh..ah...........-.......u.......ts.....s.s....t+...........lh...tt...l..h.t..s..h......hh......h..h..hh..h..h..l....hh..h.hh.h..hh.hh...............................................................................................................h...........h.t....h..h.sh..hh..u...h..h..shhGhhl.....hl....h.hhuhG.lst.l...Phshh..p..h..t.........................................................................................................................................p...........h..........................................t............h.............................................................................................................................................................................................................................................................................................................................................................................................h........h.h.h.hh......h...h....phhh..t.h...h..............................h...........................................h........h..h......h.h..h....h..ah........h.ssh.s.........h.t..h.....h..h...h.ttp.......hh.......h.p...sh...phh...th...................................................................................................................................................................................................................................................................................................................................................................	0	202	313	445
+3216	PF03923	Lipoprotein_16		Uncharacterized lipoprotein	Bateman A	anon	COG3056	Family	The function of this presumed lipoprotein is unknown. The family includes E. coli YajG Swiss:P36671.	20.90	20.90	21.10	22.90	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.58	0.71	-4.88	25	800	2012-10-01 20:48:06	2003-04-07 12:59:11	8	2	789	0	100	348	15	156.60	50	82.07	CHANGED	Pphs...ssp.ssspshslulsotDpRssphluplscssp.lphlssopslchhlppsLppphsupGapl..sssussplplplpchhssVpcushpachsoclplplhupsspG.chsKpYsussshpGs.hoAssscIcpslNplLspllscIhsDsELssalp	.....................Ppls.LPQQDPoLhGVTVSI.s.G.A.DQRsDQ..ALAKV..s.R..c..s..Q..l.Vs..LTASRDLRFLLQEVLEKQMTARGYMl......GsNGs...VsLQIlVspLYADVoQGslRY.N..IsT.KADIuIlATAtNG.sKh.oKNYRAoYsl..E..GA.FpASNcsIscAV.NoVLoDsIADMuQDTSlppFIK.................................	1	13	37	71
+3217	PF04200	Lipoprotein_17		Lipoprotein associated domain	Bateman A	anon	Pfam-B_3382 (release 7.3)	Domain	This presumed domain is about 100 amino acids in length. It is found in lipoprotein of unknown function and is greatly expanded in Mycoplasma pulmonis.  The domain is found in up to five copies in some proteins. This family also includes the Mycoplasma arthritidis MAA2 variable surface protein. MAA2 is implicated in in cytoadherence and virulence and has been shown to exhibit both size and phase variability [1].	22.40	10.00	22.60	10.10	22.10	9.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-10.47	0.72	-3.84	272	508	2009-01-15 18:05:59	2003-04-07 12:59:11	7	17	40	5	287	476	0	92.90	16	31.67	CHANGED	pls..pl....p..shphpssst...............tstlPS.plp.spsl.............................h.sshsapl..........phhp...........................ssDppGsL.plp..l.......ph.....phss.................pt...shp.lsGFps	.............................................................t.........t.php..tt...........pshhsS..pls..ppslp.....................................ts.sss.shpl................phhp.....................ssDppG.sL.plp.h..................pl...............phss..s..........................pph......php..lsGFp.........................................	0	162	287	287
+3218	PF00921	Lipoprotein_2		Borrelia lipoprotein	Bateman A	anon	Pfam-B_1509 (release 3.0)	Family	This family of lipoproteins is found in Borrelia spirochetes.  The function of these proteins is uncertain.	21.20	21.20	21.80	21.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.48	0.71	-4.24	16	1748	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	30	4	24	1776	0	138.10	61	67.07	CHANGED	lKpIV-sshKs..........tsss..sptsussspKssuKlhussusss..usus....susKAAAtluuVoGt-ILpuIspupct....tt.stsh-tsssssuhuhu.t....ptphstsuspKsAslAuGIALRuMAKsGKFAu.ts..ss..ssAVpuAuuoAVs...KlLusLphhIRKTVcusLcpl+EAlc	.................................IKEIVE.AAGGS...............EKL.Ks.......sA..A....u..t.G......E.s.NKsAG.KLF.G.K.A.G..A..u..A...p.G.DSEA................ASKAAGAVSAVSGEQI.....LSAIVpAAsA..........A........-Q-Gc.KP.t.-AKN.PIAAAIGct....-sGA..-...Fs....p....-..t..M...KK....D..D...QIAA.AIALRGMAKDGKFAVK..ss.....EK.....tt..........................................................s.............................	1	1	1	1
+3219	PF00938	Lipoprotein_3	Lipoprotein; 	Lipoprotein	Finn RD, Bateman A	anon	Pfam-B_1076 (release 3.0)	Family	This family of lipoproteins is Mycoplasma specific.	21.20	21.20	21.90	30.70	21.00	20.10	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.78	0.72	-4.21	16	55	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	4	0	21	46	0	81.00	39	33.93	CHANGED	sushpsllppsospchshu+shcLopsK+NLIssLKcuYEssPcpTsplLLsAWKhoL.-tcILpcphs.s.+F.psFGss.scpslpP	...ushcsllppooupchshu+shchspsKKNlIsuLKcSYEsNPccTsclLLsAWK.oh.-sclh.pphs....F.ps........................	1	19	19	19
+3220	PF01298	Lipoprotein_5		Transferrin binding protein-like solute binding protein	Finn RD, Bateman A	anon	Pfam-B_893 (release 3.0)	Family	This family of proteins are distantly related to other families of solute binding proteins.	29.40	29.40	29.90	29.60	28.90	28.90	hmmbuild  --amino -o /dev/null HMM SEED	570	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.99	0.70	-5.56	37	819	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	180	13	33	777	8	399.10	24	87.70	CHANGED	GGSFcl-s.....................stsssspptpP+Yp...Dssopp....pctphschppPuhGhuh+lhtpNhh..............tcc.s.lsppDh..h...................................tphptl.pthp...psspp............................................ps.p..t...ttps.pYVhSGhhYhtshs..p.tpp......hhtG..G..alaYpGppsuppLPs.....sspspYKGsWcahTs.sct...spc....ht.hst..tttssschuAhS.tp.........ctp.tsstpschuhsSEasV-FusKplsGpL..htNtphp.t.ptpstcppphYs...l-AcltGNRFpGpshs.spcsppp.....aPFso-...............spLcGGFaGPpuEELuu+FLssDpclhsVhuAKppsc......................ttpptthpshhDAhp.....................shsshsp+plss......FGcustLllsuh.IsLhs.............................................tssshtsppththtpcphpV.sCCsNLsYlKaGh...................................lppcsspt....................s........................................hFLpGpRTs.....pcplP..ppGs.scYpGoWhGal.ts....Tuaussuspppsts..tA-......FsVsFusKploGpLpspsspp..ssFsI.susIcu..NGFpGoAposc....shslDspsops.phh.h.supVsGGFYGPsAsELGGhFsassst...................................sts.supusVVFGAK+Q	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhst....................................................p.ttht.pp.hss........hs.phstLllsG..lsLhs...........................................................................t..p..ph.p.h..ss...psp.hpY..lpa.Gh......................................................hp.tstt..........................t..............................................................................ha..lpGp..s.............tptl.P......tup.shYp.Gp.hhthh..tt......................h....sst......tt....s...tAc.............VsFusKplsG.......p.l..ps...t.st.t............shph...pu.tIpu........NuF.pGshpsss.................................sspVpGtFYG......spupEluG.h..t.............................................t.tt.thhsV..FuuK+p....................................	0	10	15	29
+3221	PF01441	Lipoprotein_6		Lipoprotein	Bateman A	anon	Prodom_1149 (release 99.1)	Family	Members of this family are lipoproteins that are probably involved in evasion of the host immune system by pathogens.	24.60	24.60	31.60	31.50	24.30	24.10	hmmbuild  --amino -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.18	0.71	-4.45	42	763	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	58	21	5	741	0	168.60	61	91.18	CHANGED	-.tSspsAcpsups.sLscISKKIpDosAFshuVKEVETLlpSIDELA.KAIGKKIpsss...sLsss...usp..NsoLlAGAYsIushIspKLssLpsspt.....LKpKlpcuKpsScuFssKLKspHu-LGtss...soD-sAKpAILKoNss.psKGAcELccLspuV-uLhKAAptAlssulKELT.uPVhA	..................s..sSsNsADESsKGPNLTEISKKITDSNAhVLAVKEVEsLLuSIDELA.KAIGKKIcpNs..uLss-..usp...NuSLLAGAYsISo.LITpKLssLcsppt.....LKcKIpcAKKCSEsFTsKLKssHAc.LGhps...sTD-sAKcAILKTsus..KDKGAcELccL.cSVEuLuKAAp-h.LsNSVKELT.sP..............	0	1	1	1
+3222	PF01540	Lipoprotein_7		Adhesin lipoprotein	Bashton M, Bateman A	anon	Pfam-B_615 (release 4.0)	Family	This family consists of the p50 and variable adherence-associated antigen (Vaa) adhesins from Mycoplasma hominis. M. hominis is a mycoplasma associated with human urogenital diseases, pneumonia, and septic arthritis [1]. An adhesin is a cell surface molecule that mediates adhesion to other cells or to the surrounding surface or substrate. The Vaa antigen is a 50-kDa surface lipoprotein that has four tandem repetitive DNA sequences encoding a periodic peptide structure, and is highly immunogenic in the human host [1]. p50 is also a 50-kDa lipoprotein, having three repeats A,B and C, that may be a tetramer of 191-kDa in its native environment [2].	24.10	24.10	24.10	24.80	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.31	0.70	-5.38	3	40	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	3	0	2	41	1	200.70	50	99.44	CHANGED	MKKSKKIFITLCGIAATAILPVATISCNDDKLAEKNGKEKADAALKQANALAEELKKNPDYSKILETLNKEIAEATKSFKEAGSYGDYPAIISKLSAAVENAKNEKKAIDDKNAQIA......................................................................................................................KELAERNAKIQSNIEELKKINNEAFELSKTVNKTIAEVEKKFKI-ccFKEQLENFADDLLDKSRQIDEFTTVTSTQEGFTLAELESFKEITTTWFNGMKSEWARVLDAWKNELTEIN...SIIKGVEELKKLSHEISEFSNSVKKTISELEKKFKIDDKTNK-EAKpFKNELENFADQLLNKSHEIDKFVTVTSARcDFSLSELESFKSFNTTWFNEMKuEWARVQEAWKDQLKEISTK	............................................................................................................................................................A-ENtKIppGhcELhKLScchpshucTIshTIsKLE.KKFpIDcsFKcQLhSTI-.LNKKSsElcTFsTVsohKc-FlLuELESFKEhNToWhp...cIhSEWtcVpcAWpcELsEIp.............................................................................................................................s............	0	2	2	2
+3223	PF02030	Lipoprotein_8		Hypothetical lipoprotein (MG045 family)	Mian N, Bateman A	anon	IPR000044	Family	This family includes hypothetical lipoproteins, the amino terminal part of this protein is related to Pfam:PF01547, a family of solute binding proteins. This suggests this family also has a solute binding function.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	493	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.79	0.70	-6.00	3	61	2012-10-03 15:33:52	2003-04-07 12:59:11	10	4	56	0	17	843	30	438.40	27	76.45	CHANGED	MKKQLKYhFhhhGlT....hSsILTACS.SopFVlANFESYlSP.LLLERAccK+P..LTFLTYPoNEKLINGFANNTYoVAVASoYAVSELtcpGLLpPIDWAKFNLKKosNuSsp..lpNtEDAK-LFTKpIt-ISpth........KDuKNsELLcWuVPYFLQDLVFVYRGEKIsELE..pcDVoWSDVIKAIV+...HKDRF......................NcNRLlhIDDARTIFSLANIVphE..sKNNolDVN.............................................PKEsslNYFsNVYESFupLGLK+sNLsolFVN.........SDSNIVINELAsGRRQGGIVYNGDAVYAALGGDLRDElsE...NplPsGDNFHIVQPKcSPVALD.FLIINpQQopFccAAHElIa-LAL-GAD..................QTKEpLlKTDEEpGTDD........ED.aYLYGAMQNFSYVNYVSPLKsIS....DEoTGIVuKcsppADhKp.hKQpS.o-Qpo.poEKEc..............sc.aDaYTcTLKuLLp...KsDShE...........LN-psKKLV-TIKKsYpIcKs-uIp.........................WsNLlEKPIoPLQRSNLoLSWLDFKp+a	..........................................h..........hh...h.h..u..hs............h...s...h..l...o.....u.s.....t......p......s.........c.......L....V..lu...Na..ssYlsP.plh...t.E...p.tpp.h..p.s...............plsYphassNEhl...h...s....tl....+....s...s...t.....YDltlsSsYhVs+LtppshlpKIsa....SK...h.s.....l..h..tpt...s.p..t...p..........s.pthpp.hs.cphhtl.tt.......................................ps.s..plL-YhlPYahpDL.lhsap..s..ppl..p.Lp..pppl.a..phhpth..p...p.pph.............................sp.s..K.hh.l-stpp.hsl....uphhp.t......psp.hphh..............................................ht..ph.h.hss.ppht.lt..........t.hpph..ss..hhhN..........ssSs.lls.ls.tph..ts.ul.hYsGDhhaAs......sG-.....p.E.hsp.............h.stp..s.h+.lc.pso..hhD.hhl...p.....s...tp......ptAYphlpplhh.tuhp............................p...............p.................t...h......s....h.NFsaltYsss.................................................................................................................................................................................................................................................................................................................................................................................	0	10	14	15
+3224	PF03305	Lipoprotein_X		Mycoplasma MG185/MG260 protein	Mifsud W	anon	Pfam-B_4433 (release 6.5)	Family	Most of the aligned regions in this family are found towards the middle of the member proteins.	20.60	20.60	27.40	27.40	20.50	18.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.72	0.70	-4.99	17	77	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	34	0	32	75	0	232.50	27	33.10	CHANGED	LlDFuoRlAKSFsc.lps.p.sKKus-lQGVLGlDSssNsLaousFAuGsGsYsNFFapl....psupsDFsNFhNK.so.oYpNLpclaNcaKsLIspNGLalN+G.GoYoSNapKFHQLAFuloSTSGahauFAspsu.K.RLpFssps.......hpaPphT.....ppl..+sPspspp.tsh..tspstspsNLLGshslpssph.......pt.t.t.....................t....s.pspu......KsIplYKspIsssKpts.sAlL............Ipsp	.........................LlDFusRltKSFsp..p..p.sppssshpsVLGlDssssslasssFAs..usGshssF..hhpl............p...s....s..pscass.Fhs+.so.uYpNLpclasphpphlpppula....lspu..GsYoSs.atphHQhuFuIuSTuGYhasFsspsu..K..plpFspss.......hpaspho........ppl..pssspspp.tsh...t.pp..pt.psshlhphshpsspt...............p.............................t.tp...t..t.ptpt..............ch...hct....h.pttp.t........................................................................................................	0	20	30	30
+3225	PF00305	Lipoxygenase	lipoxygenase; 	Lipoxygenase	Finn RD	anon	Prosite	Domain	\N	19.40	19.40	20.70	20.00	19.00	19.30	hmmbuild  -o /dev/null HMM SEED	667	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.13	0.70	-13.09	0.70	-6.54	16	1473	2009-09-11 06:47:26	2003-04-07 12:59:11	14	34	251	68	681	1491	13	407.70	28	73.57	CHANGED	PusLhKYREEELcsLRG...-GTGchcta-RIYDYslYNDLGsPDpstp.sRPlLGGotpaPYPRRsRTGRtPTcpDPsoEpc.....s..hYlPRDEpFGHlKpsDFLshulKulsQsllPthpus...hp.hssEFcoFcDVcpLaEGGlpLP....hphlsph.Pl.hlc-lh+TDGpt...hL+assPpVlphs+ouWhTDEEFAREhLAGlNPslIcplpEFPsKSpLDsthYGspsSsITtEcLE.pLcG.hTV-EAlpsp+LFlLDaHDhhhPYlp+INs.sssKsYAoRTlLFLp-DGTL+PlAIEL.ShP+PsGc..u.sSpVahPu.-Gspu.lWLLAKAaVhVNDushHQLlSHWLsTHAlhEPFlIATNRpLSslHPIaKLLhPHaRsT.MNINuhARpsLlNusGIlEpohhsG+Yu.hEMSuslYKs.WsFs-QALPsDLlKRGlAlcDsouPaGlRLhIEDYPYAsDGLEIWsAIKoWVp-YVslYYtoD-slppDsELQAWWKElsEhGHGDtKDcPWWPKhQTp--LlcssTllIWsASALHAAVNFGQYsYuGal.NRPThoRphhPp.sTsE...a--lhps.pKsaL+TlssphQollslollElLSRHuoDElYLGpR-s.p.Wss-tcshtAFc+FGpKLp-IEccIstRNsD.sLp.NR.GssphPYTLLhPS	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tW.pD..FuhphlsGhNP.h.lp.....h.....h.....p.....................t..h..P..........................................s....t...l...............h....tt.......h..........t..............t..h........p......t.tpla..hh...D......a.....t.......h.........h.................h..............t.....h...............t.........t.........t..........................t......h......hhu..shsl.hh.....h.....p..................t......s......t.....L..hP.lAIp.l.....p.....P..............s..............................l..h.....h......P......s.............p.....s...................s........W.lA..Khas.ss-.thHp..hhsH..h...........lpTHh..h..Es..hhlAs....R..pL......s.hH.Pla+..L.L..PHhc.T.htIN..shARt.Ll......s..t.....t..........G.....h...h....-.........s.............h..................s.................u..h.p.h..th.h.h.tp...h..t..at....t....s..hPtsl.h.tRG...h.....................................l...sY.Yt.Dul.lWtsl.....pp..................alpthlt..h.aY...............s....s.....t......lttD..E..........LQsWh.p.-h........h...p...........G......h.........t...........h..............p.....t........t...s..h........p..h.po.........tpLhphhThhlahsou.HuAlNh......uQ.h.s.hhu.a.h..P..NhPs..p...P..t.............t.......t...........h.......................hts.hs..s..ts..h..h.....hh...hLu.p.............s.................l........Gp....h....t..................h.........p.......................t......httFttp.l..t.l..tt.l.thNt..t.......h..............................s.Y.hh...............................................................................................................	0	146	331	477
+3226	PF04778	LMP		LMP repeated region	Kerrison ND	anon	Pfam-B_2380 (release 7.6)	Family	This family consists of a repeated sequence element found in the LMP group of surface-located membrane proteins of Mycoplasma hominis.  The the number of repeats in the protein affects the tendency of cells to spontaneously  aggregate.  Agglutination may be an important factor in colonisation. Non-agglutinating microorganisms might easily be distributed whereas  aggregation might provide a better chance to avoid an antibody response since some of the epitopes may be buried [1].	23.60	23.60	23.70	23.70	23.10	23.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.13	0.71	-4.47	6	52	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	10	0	11	48	0	142.60	60	48.35	CHANGED	sANpLLspLsDsDscItcAKopL-pEIppANQAlsSNNsASMQSAKSSLDAKVsEITKKLETFNKDK-AKFpELEQTRKsI-EFIsss.KNNP....NYusLlppLTsK+DuKNSVTsSSNKSDIpuANsELKQALscApssKsQlDshsKSlKEQLsspIs	..............sANpL.spLoDpDspIQpAKo-L-pElpKAsQAltSNNTASMQSAKSSLDAKVsEITKKLETFNKDK-AKFpELcQTRpQIQEFINTN.KNNP.....NYS..ELISpLTSKRDSKNSVT-SSNKSDIEoANTELKQALsc.....ApscKsQsDNhsK....ShKEQLssols......	0	11	11	11
+3227	PF01451	LMWPc		Low molecular weight phosphotyrosine protein phosphatase	Bateman A	anon	Prodom_2132 (release 99.1)	Domain	\N	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  --amino -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.85	0.71	-3.85	27	7884	2009-09-12 21:07:05	2003-04-07 12:59:11	16	44	4157	78	2043	5778	2186	133.10	26	83.15	CHANGED	lLFVChGNhCRS.hAEulh+phh.t..hstth.plpSAGsp...supssc.pulplhccpGlslst+hu+plspp....hpphDlllsh.spsthtphsshhPt...hp................phplsDPh...tps....ssFcplhstIcptspphh	.......................lLFVC..h.GNhCRSs.hAEulh+phh.........................................t............t.............p.............h....plp......SAGs..........t.....t...................u....p......s....scs.t......uh.p.s........h..p............c............t......G.............l................s............h.......s...s...........p..p..u.+...p...l...s..p..p............hp...p...h...DhllsM...sp.p...ph...t..p.......l....p.t...hhPs..............hp.ph...hhtp...................................................phslsD..Pa.............h.ts...........tsF.c.....p...shc.lpptspth.................................................................................................	0	663	1320	1746
+3228	PF03548	LolA		Outer membrane lipoprotein carrier protein LolA	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.00	22.00	22.00	22.00	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.63	39	2649	2012-10-01 20:44:21	2003-04-07 12:59:11	10	3	2149	7	649	1876	1519	159.10	24	75.94	CHANGED	splpohsusFsQpshssptt...pspGphhlpRPshhRWphssPpcphlluDGcslhha-splcQs...h....htpslspoPhhLLh..psptphtppasls......tthtshhLpP+.ttssshpphplshsppsh.lpphplhDp.Gpcoplthpshp.ssslssshFpFs	..........................................................................t.thpohpusFs.Qp...s.........p........s....s..........s....h............t................................p.upGp...hhl.....p......R.....P....s........h........hpWch...s.p..P........t...p..........ph...l.l.uDGcpl..h..h...a...s....s.......p.....l.......c.....Qs.....shp.........hpp..s....h...s.....s.....o....Ph.......h...llh............tsp.ssh...p...p.a..........s...lp......................................................p......s.........t....t....p.......h...hL..s..P.....+....s......s....s..s.s......hp......p...h...pls...h........s........p......s.......s.....h...lpph...............p......hh-...p..p.s.p.p...o.s.hp..h.pshp..s.s.sl.ssshFpa..........................................................................	0	183	390	523
+3229	PF03550	LolB		Outer membrane lipoprotein LolB	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.00	20.00	21.20	21.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.87	0.71	-4.64	24	1327	2012-10-01 20:44:21	2003-04-07 12:59:11	9	2	1272	3	243	817	151	154.60	36	75.40	CHANGED	plppaphpGpluhh.....usppphuupF.Wppp.sppacLtLossLGpTtlplps..psssspLpsscGphhsussuctLlp.clhGhslPlspLt.Wl...........pGhPs...ssschplDsptpltplpp....psWplsY.pY.....pppsts.LPpplpLp.....pss........hpl+LhlspW	..........................p.lspapscGthAhh...........usp.pps.ApF.h.WQQs..tcpacLh..Lo.s.P.L.GsTtlpLss...psusspLsss.cGppYsAs-AEch.lt.cloGh..slP..lssL+pWl...........................hGl.Pu....sssch..pLD...s.p..h......+.L.spls................psWpVsYtsY......................sspsp.ss.hPpplcLs.....s..s.s........tcIKLhhcpW................................................	1	45	119	188
+3230	PF04728	LPP		Lipoprotein leucine-zipper	Kerrison ND, Coggill P	anon	DOMO:DM04880;	Domain	This is leucine-zipper is found in the enterobacterial outer membrane lipoprotein LPP. It is likely that this domain oligomerises and is involved in protein-protein interactions. As such it is a bundle of alpha-helical coiled-coils, which are known to play key roles in mediating specific protein-protein interactions for in molecular recognition and the assembly of multi-protein complexes.	28.40	28.40	28.40	28.40	27.70	28.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.87	0.72	-4.17	19	1023	2009-09-10 20:56:13	2003-04-07 12:59:11	8	1	668	20	75	206	2	55.30	64	68.34	CHANGED	SNAKIDQLSSDVQTLNAKVDQLSNDVNAhRoDVQAAKDDAARANQRLDNps.psY+K	................sA.KlDQLSS-VQTLNAKVspLosDVsAhR.......u.......sl.......p.......AAK-.......-AARANpRLDN.u.ppYpK.....	0	7	21	47
+3231	PF02169	LPP20		LPP20 lipoprotein	Mian N, Bateman A	anon	IPR002217	Family	This family contains the LPP20 lipoprotein, which is a non-essential class of lipoprotein [1].	22.10	22.10	22.10	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.99	0.72	-3.89	81	734	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	501	0	158	508	331	101.10	22	44.89	CHANGED	ss........shssspph...lhAh..............+uuphsAh+pLup..plhshplsupss...................spshhhpsspl..pstVsuhl.........+...Gscllps.h.......ssspah..s.lplc	...................................................s.spth.....hhAhG..u..................+AAph-AhcpLAp....plhGhplsupss...................lpsthhp..s..p..pl....pspVsu.h.I............+.........suc.llcp.hh.......spsh...ah.splcL......................................	0	55	103	136
+3232	PF04348	LppC		LppC putative lipoprotein	Mifsud W	anon	COG3107	Family	This family includes several bacterial outer membrane antigens, whose molecular function is unknown.	28.70	28.70	28.70	28.70	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	536	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.71	0.70	-5.95	6	1623	2012-10-02 13:57:41	2003-04-07 12:59:11	8	4	1023	1	224	1425	378	366.20	30	91.36	CHANGED	pscsNAou-hYlp+ssQoQs.p-ppsa+LhAA+lhlpENclsQApALLtcLs..sLsspQplctuLlcAcluAs+ppspsA.pQLph....sLspLSsoQpsRYacstAplhEsctDslsAsKtRIphDphLosspc+ppNtD+hWuLLpshssuVlps..ssstssssLuGWLsLsphhss.hspPsQLppolpsWpst.PpHsAAphhPstLpsLhshpQsshoplALLLPLoGshthlupsI+sGFssA+......spsssslplFD.Tssp..ol-slhsQAppsGIchVVGPLlKpNV-hLhspsQ..hQslslLALNtosNs.cu.hupLCYaGLSPEDEAcuAAs+hWsDGhRpPlVlsPQN-lGcRsssAFs.RWQphuGoc.Aslcaas.PuDlshplp..........................sspppssDuVYllAssspLspIKshLss.....stshtlYAoS+ussu..NssP-pct.LsGlpFSDIPahhsssssphp..cls.+hspuchuhhRLYAMGsDAWhLhsphsEL+tV.PGasIDGLTGpLShsssCNVER-hoWhpapsG	................................................................................................................................................................................................................................................................................................................................................................................................................................h..........................................................hh.....h..............................................t..a....h..t..............................h...........t..s.........................................................................................................................................p....hulhLP....s...G......h..t..........up....hlppGh..uAh.......................s...p..........s......s......t..l..p....l..h......D...o..sut......sh.s..p..l...ht..Q...s.p.tp.s.s...shVlGPL...+...s....p...V....p..t..L.h..t............p..tt.............................................slss.L.A...LN........t..s.......p.....s......s..........t...........h.............h....uL....u.s..pp..-...s...t..h...A.ph..h...h....t.p..t..h.p..........sh.hh.h.s.p.st...up.R.h..tsF..t.....att..s....tt........................h.....t...................p...h...t..........lt........................................................................h...s..h.hah.h.s.t...t.p.h...lhs.lt............hhss....Sp...........t.t.t........hpsl........hs.p..h.Phh..h.......t..........................................h....................................................R.h.....A.h.GhDuh...l................h.t.......h...........t..............t..th..G.oG.Lth...t...t..t....l.Rt..h...............................................................................................................................................................................................................................................	0	40	100	165
+3233	PF02684	LpxB		Lipid-A-disaccharide synthetase	Bashton M, Bateman A	anon	COG0763	Family	This is a family of lipid-A-disaccharide synthetases, EC:2.4.2.128. These enzymes catalyse the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl) glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl  1-phosphate <=> UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6 -beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. These enzymes catalyse the fist disaccharide step in the synthesis of  lipid-A-disaccharide.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.20	0.70	-5.83	8	2446	2012-10-03 16:42:30	2003-04-07 12:59:11	10	6	2354	0	585	1902	2953	358.50	35	93.79	CHANGED	IalSAGEsSGDhlGupLlpsL+pcY.....sh+FhGluG.pMpt.pGhcsLhshcElulhGhhElLs+Lh+Lh+lhccll+phlpppsDslIsIDuPsFNlpLtK+LRKpGh+h.IIHYVuPSVWAW+spR..spplt+hsDhLLAILPFEpsaacKhs.LcspYlGHPLsDpIphpss.cspt+-hl.lspsc.hlslhPGSRcuEIp+h.hslhspAtplppphsslphlVslssscact.h.phhtt.shplshlhhsstshcuhhsuDhALhpSGTssLEsuLstoPhVVsYRl+PloaaLAKhLlKlpY..lSLsNIlhsctlhPEhIQtcschphhuhtthhhLtsspp.tcpp+stpcchpphhphtpsptccphsphh	.........................................................................................................................lhllAGEsSGDlL.Gu.sLl+AL+....t......ch.P................s.sc....FhGluGs.p..MpA...p........Gh...cuh.a.chc-LuVMGl.....l.....EVL.....t+L.cll+h..tp.clhc.ph.h.p.....pP.....DlhlsIDuPDF.Nlpltt.pL.....K.........p.....p.....G.l......c....................s......l.....+YVS.PSVWAW.R..p..p.R...............lhcIt+ssDh.lLulLPFEtsaY.c....+.......h.......s...l.s..........spalGHs.h.s..D..............t...............h..............s......h............p.........s........c.......c...........t.............s...s...+.............ph...L....ul..............s..............t............s..........t.........t.....h..lA.lLPGS.Rt.uE.lc.......hLhssFlp.....s.....u....p....hL.......p......p.......p.......h.....Ps....l.c.....h.l.l...P..h...s...s....s.....pp...c....p....h.......p.p.....h.....h........t.......p.......h.......s...s...............p.....l........s...............l...h.........l..........l.......c.........s........p..........s......p.....p......s........h.t........Au..D...suLluSGTAsL.EshLh+sPMVVuY+..h..p..s..h.o..a..h.................l...u..+..+...l..l...K.....h..p.a................lo...L.PNll.....u.....s.....c.......p....l......Vs....ELlQ.-csp....sppLut..tlh...lLt.s.s.....t....thht.h.................................................................................................................................	1	184	368	488
+3234	PF03331	LpxC		UDP-3-O-acyl N-acetylglycosamine deacetylase	Mifsud W	anon	Pfam-B_3666 (release 6.5)	Family	The enzymes in this family catalyse the second step in the biosynthetic pathway for lipid A.	20.60	20.60	21.00	20.90	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.68	0.70	-5.45	10	2676	2012-10-03 01:04:38	2003-04-07 12:59:11	8	8	2359	35	672	1850	2808	253.70	43	87.84	CHANGED	hc..Q+TLK+.VphoGVGLHoGcpspLTLcPAtsNTGIlFhRoDLss..shlPAchss..Vt-TthSTsLupc.sspIuTVEHLhAALtuhuIDNlhIclsusEIPIhDGSAtsFlhLIppAGIpEp..puscchh+IpcsVpVpcpDpaltshPssshclsaTIDFsassls+.sQthohs..hsp-uFtcpIApARTFGFhp-IEaLpspGLstGGSL-NAlVlD-.s+lLNtsGLRFtDE.VRHKlLDLIGDLhLlGpsllucahuaKoGHuLNspLl+pllsspc	....................p.Q+TLpp.lphsGlGLHoGcc.V.plTL...cP..As....s...s...oGlla.p.R.s..D..L......s............s....s.........sphsAs..sps..V..t.....-.....T.h..h..sT.sL.......ss....p....s.....s..........+luTlEHLhuALsuhGI.DNhllE.l.s.u.........s.........ElPIM.DGSAtsFlhh.ltpAGlpE.............sss.......K.........+.....al...+.I..pc..s..V..c...V........c..-....G.....-....K..a..s..c...hp...P.....h...s...........u.....apls..asID....Fs.c..P...s.Isp..Qp.hshs......hs...s.....p......s.FhcpIucARTFG......F..h.+......-...............l.....E......hLpu....tGLshGG.....S.h.-NAIV..........lD-.....cl......L.N......p..-G.............LRa.....c.D...EF.VRHK.hLDAIGDLhhh.....G.t..s.....l.lGtapuaKuGHsLNspLlctllsp.............................	0	209	429	564
+3235	PF02606	LpxK		Tetraacyldisaccharide-1-P 4'-kinase	Bashton M, Bateman A	anon	COG1663	Family	This family consists of tetraacyldisaccharide-1-P 4'-kinase also known as Lipid-A 4'-kinase or Lipid A biosynthesis protein LpxK, EC:2.7.1.130.   This enzyme catalyses the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D -glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosam inyl  beta-phosphate <=> ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D- glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate.  This enzyme is  involved in the synthesis of lipid A portion of the bacterial  lipopolysaccharide layer (LPS) [1]. The family contains a P-loop motif at the N terminus.	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.22	0.70	-5.48	173	2466	2012-10-05 12:31:08	2003-04-07 12:59:11	9	11	2274	0	558	1911	2496	293.20	33	91.66	CHANGED	hthLLhP....lohLYuhlst..hRptha.....t.shh.pshch.slP.VlsVGNlosGGsGKTPhllhLsctLppp..Gh+sullSRGYGucsp...s..shhV.ssss............ssspsGDEPlLlAp..pss..ssVhVutc.Rspusptllptts...s-......................lIlhDDGhQHhtLt........RDl-llVlDu.....tRshGNGhlLPAGPLREPhs..pLpcsDh.l..lh.......sssps..ttt.......h...............................................thpLt..P......................h.....t...sspt.s...l.psh.h.........hAhAGIGpPp+FFsoLcp.hGhplhtspsFsDHasastp-lptltpt..p.........ll.hTEKDAVKht................................p.......hhhlslcspl.....ssshtphlhptl....p	..........................h..hlLhPlShLYuhlsth+phha.............t.hh....psh.......ch..slP....V.lsVGNlosGGsGKTPhllhLsctL.ppp........G....h...+.sull.SR..GYGu+sp................s....shll.ssps........................sstpsG...DEPlLlhp.........+ss.....ssVsVuss...Rspu.s....ctllttts.....sp............................lIlhDDGhQHh.t.L.t........R.Dl-IlllDu........hR.h.hGN.s....hhLPuGPhREshs..pLcp.s.Dh.llh.............sus.s..p..t.s..t...h..............................................................hpLh.st.h..................................................hth.t....ssptps.........h.tt.h.ph...........lAhAGIGpPtRFFso.Lct....h....G.......h.phh.............t.......s.....hsasDHpsastt-..lptlhp...t...........ll.hTEKDAVKhp.s......hst.t.................p............hahLslcspl.......ssph..thl.....t...................................................................	0	177	353	466
+3236	PF03788	LrgA		LrgA family	Bateman A	anon	COG1380	Family	This family is uncharacterised. It contains the protein LrgA that has been hypothesised to export murein hydrolases [1].	28.00	28.00	28.30	28.60	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.10	0.72	-4.29	148	3245	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	2309	0	485	1676	121	95.60	31	72.62	CHANGED	h.hlGchlsphht..lPlPGsllGhlLLhhhLh.ts.hlp..............chlctsushLLpphsLhFVPuuVGlhsahsl.ltpphh.lllslllSTllslhsouhlhp	......................hhhGphlsphhs..lPlPGSllGhllLalLLt..hp.ll.h.............caVcsuu.....shLlp.hsLhFVPsuV.ulhpahsl.lp.tphh.lllslllSTlllhlssuhss.t...................	0	117	247	369
+3237	PF04172	LrgB		LrgB-like family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The two products of the lrgAB operon are potential membrane proteins, and LrgA and LrgB are both thought to control of murein hydrolase activity and penicillin tolerance [1].	25.00	25.00	26.90	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.33	0.70	-5.19	36	3458	2009-01-15 18:05:59	2003-04-07 12:59:11	11	6	2403	0	586	1883	148	210.90	35	88.87	CHANGED	Tlhsahluphlac+h+t.hh.sPlLluhllllslLhhhs.........IsYcsYhtuuphlshlLuPA.TVALAlPLYcphchl++aahsIhsulllGulsuhloshhlA+hhuhsptlhhSlhPKSlTTPIAhtlopplGGlsslTAlhVllTGllGullGshll+hhpl+cs.lA+GluhGsuuHAlGTA+AhEhGpppGAhuuLuhslsGllosllsPllhtll	..............................................................................Tlhsahhuphlhp+h.p.....h.....hL....sPLll.uhllllsh.Lhlhs............................IsYpsYh.p...G.........up.hl.......shLLtPA.sVALAlPLYcph.c.hl+cp.a.hs....Ilsul.hlG.o.l.lu.hhosh...hlA.thhGh..s....p.pl.hhSlhP+SlTTPIAhslup.........p...........lGG.......h.s..sloAlhVlhsGllGul.l.G.thlLch...h.+I..........c................s....s......hA......+........GluhGsuuHulGTA+uh.Ehu..p.-GuhuSLuhslsG..llos..ll..sPhlh.l.h...................................	0	145	310	457
+3238	PF01462	LRRNT		Leucine rich repeat N-terminal domain	Bateman A	anon	SMART	Family	Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.58	0.72	-4.39	26	4081	2009-01-15 18:05:59	2003-04-07 12:59:11	13	511	131	66	1403	3750	2	29.00	41	7.50	CHANGED	tCP.htCpCs......spsVpCsstsLp..plPh.lP	............CP.s..tCsCs..........................sssV.pCss+...sLs...slPssIP......	0	249	354	721
+3239	PF01816	LRV		Leucine rich repeat variant	Bateman A	anon	PSI-BLAST	Repeat	The function of this repeat is unknown. It has an unusual structure of two helices. One is an alpha helix, the other is the much rarer 3-10 helix.	21.30	21.30	21.30	21.30	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.84	0.73	-7.10	0.73	-3.41	56	206	2012-10-11 20:00:59	2003-04-07 12:59:11	12	15	101	4	120	200	32	25.00	40	14.00	CHANGED	hpVRttVAp+..hPsctLttLsp..Ds-	........tVRtsVApp.thPsphLtpLup..Dss..	0	37	87	114
+3240	PF05083	LST1		LST-1 protein	Moxon SJ	anon	Pfam-B_6166 (release 7.7)	Family	B144/LST1 is a gene encoded in the human major histocompatibility complex that produces multiple forms of alternatively spliced mRNA and encodes peptides fewer than 100 amino acids in length. B144/LST1 is strongly expressed in dendritic cells. Transfection of B144/LST1 into a variety of cells induces morphologic changes including the production of long, thin filopodia [1].	22.30	22.30	22.40	24.60	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.81	0.72	-3.98	3	46	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	14	0	6	49	0	61.30	43	73.44	CHANGED	LGGLLLLsVlLLoI...................CL.......CuhSpRVKRLERutpsuG.cQEPHYASLQQLPVSSSDITDM........KEDLSTDYACIARSTPT	...........................LGGLLLLhVllL.h...................CL.......ChhppRh+tLEpsh.........t...QE.hht.L..LPs.sp.-h.th..........pED.psDYACIs.s................................	0	1	1	1
+3241	PF00677	Lum_binding		Lumazine binding domain	Bateman A	anon	Pfam-B_291 (release 2.1)	Domain	This domain binds to derivatives of lumazine  in some proteins. Some proteins have lost the residues involved in binding lumazine.	21.30	21.30	21.30	21.80	20.40	21.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.58	0.72	-4.09	20	8363	2012-10-03 00:38:56	2003-04-07 12:59:11	12	15	3923	28	2044	5873	3972	84.80	32	79.71	CHANGED	oGhlcusupItpIpcp......ssshphslphstptLpchhls.soIulsGlSLTVscls....ssthplslh.cTlp.pTshsphKlGscVNlEhs	................................oGhl-shGplh...p.l...p.p.p...................ss...s....h....p....h..pl........p..s....s...........................t....................l..t......c.......h..h..ls..uSIAlsGlsLT.V.....s.....c.....l.s.....................ss....p......Fs..l..s..l..h..scTlp..pTsL......u...p......h.....p.s.G...s.p.VNlEts..............	0	668	1327	1740
+3242	PF00894	Luteo_coat		Luteovirus coat protein	Bateman A	anon	Pfam-B_123 (release 3.0)	Family	\N	20.30	20.30	22.60	27.60	19.90	17.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.71	0.71	-4.40	13	1368	2012-10-04 01:49:40	2003-04-07 12:59:11	13	2	47	0	0	1080	0	131.00	58	53.22	CHANGED	ETFVFSKDsLsGNSsGoIsFGPSLS-CPAFSsGILKAYHEYKITplhLpFlSEASSTouGSIAYELDPH.CKhSoLuShINcFoIoKuGpKoFouctINGtpW+DSoEDQFtILYKGNGsSS.lAGSFRITI+VthQNPK	..EsFlFShDsLpuNSoGsIpFGPSLSpCPAhSsGILKAYHEYKITulplpFhScASuTouGuIuhELDsp.CK.SuLuShINpFsIoKsupKsFsAphINGpEap-o.........otDQFhlLYKGNGsoo.hAGpFhIphps.h.s................	0	0	0	0
+3243	PF02122	Peptidase_S39	Luteo_ORF2; 	Peptidase S39	Mian N, Bateman A	anon	IPR000382	Family	This family contains polyprotein processing endopeptidases from RNA viruses.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.03	0.71	-5.01	15	486	2012-10-02 13:45:52	2003-04-07 12:59:11	10	4	34	1	0	526	2	164.30	35	39.72	CHANGED	VcGapoaslPpsPPKsuVlplp+ssGoHsGYAoC...lpLasGpsuLlTutHslsc........sttstSh+sG..sKIPL..s-F+slhcssptDlslLpGP.PNWEuhLuCKusphsTsspLu+usAohashccst.WhussAc....IsGs....p..sp.assVLSNTcsGaSGoPYFsGK.sllGVHpGt...sscscNaNh.MuPIPslsGLTSPsalaEoTuPpGcl	.........................pGhh.aphspp.scasV.thh.PsDp.ht.Aos.....s.h.ssEcAhhsu.ts.sp.........s.t..s.c.ph.+ss....phPL...sE.p.h...L.....s..s..hhs.ll.phs.sphtshlttKhh+.t.spp.....p..pushp..hh.....cp.....h..psuc.....s.ts..p..sh..ssVh..S.p..s.pts.hussPhash..p.htsHpG....uppsppap..huPlssh.....Pp....ss..p....................................	1	0	0	0
+3244	PF04662	Luteo_PO		Luteovirus P0 protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_4444 (release 7.5) & Pfam-B_3579 (release 10.0)	Family	This family of proteins may be involved in suppression of PTGS a plant defence mechanism [1].	26.60	26.60	27.00	45.30	24.60	26.50	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.09	0.70	-4.87	8	137	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	22	0	0	137	0	208.60	35	86.25	CHANGED	llsp.sRpLhsp-RshhsutFLhphshhlsh..............t....cspthlRSlLatLPLLL.....sG-hhassuthph.h.....LsRaultsGhsPsso.........psslcLplPuocsshRhhLtRssoouLuE+lpRap-sLt.pGhcpFp+FLssahpshERpLscsshcsshssphhl-LssLGstLtchVhspplhppuhhoclAhthp+laGEssuls	........................lhlppsRhLhhcpcshlhuhhLlsItphlph...........h..t.st.p.l-hhlRSLLatLPLLl........Gct..lasssthph.h.....hscFuLhsGhtPsso.........sttlcLclPsTc.suhRphLtRssuSshuE+hpRhsEshh.puhEtFpRhLusahcptERplhpustc..hGscphl.LusLGphLtchVsspphpppshhuclAhthp+laGEstuh.................	0	0	0	0
+3245	PF01659	Luteo_Vpg		Luteovirus putative VPg genome linked protein	Bateman A	anon	Pfam-B_970 (release 4.1)	Family	This family consists of several putative genome linked proteins.  The genomic RNA of luteoviruses are linked to virally encoded genome proteins (VPg).  Open reading frame 4 is thought to encode the VPg  in Soybean dwarf luteovirus [1]. Luteoviruses have isometric capsids that contain a positive stand ssRNA genome, they have no DNA stage during their replication.	25.00	25.00	26.80	49.70	24.10	18.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.09	0.72	-4.34	8	687	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	39	0	0	510	0	103.60	47	67.26	CHANGED	l.h.E-QAphRHSaSQRTsS+sTPpEVSsSGRlYQsApHSpMEYSRPTMsIRSQsShaSSSsRPLP..sVPSLhshT.sApspP.ssp.hsStStpsspcsSphp	.......hh-ppAshRaSaSQpTsS+sT..tpSsSuRlYpsAQ+SphEYS+PTMsIRSQVShaS.StpP.P.pps.SLhshT.pAssp.asspLIsSsSt+hs.psSp..t......	0	0	0	0
+3246	PF04443	LuxE		Acyl-protein synthetase, LuxE	Kerrison ND	anon	DOMO:DM04138;	Family	LuxE is an acyl-protein synthetase found in bioluminescent bacteria.  LuxE catalyses the formation of an acyl-protein thioester from a fatty acid and a protein.\	      This is the second step in the bioluminescent fatty acid reduction system, which converts tetradecanoic acid to the aldehyde substrate of the luciferase-catalysed bioluminescence reaction [1] A conserved cysteine found at position 364 in Photobacterium phosphoreum LuxE (Swiss:Q52100) is thought to be acylated during the transfer of the acyl group from the synthetase subunit to the reductase.  The carboxyl terminal of the synthetase is though to act as a flexible arm to transfer acyl groups between the sites of activation and reduction [2]. This family also includes Vibrio cholerae RBFN protein (Swiss:Q06961), which is involved in the biosynthesis of the O-antigen component 3-deoxy-L-glycero-tetronic acid.	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.34	0.70	-5.77	7	387	2012-10-02 15:58:18	2003-04-07 12:59:11	7	5	327	0	124	413	321	321.20	24	83.12	CHANGED	Ms....lcppplhuSoElDDlIF.upP.phoh-EQcplpp+llhpua.aHYppN-pYRpaCpsptVs..-sl...ps..IsDIPVFPTSlFK.....a..t+LhTss--cIEsWaTSSGTSGlKSplAR...DRlSIERLLGSVsaGMcYVGsaa-HQhEL.lNlGPD.....RFNusNIWFK....YVMSLVELL...YPTs..FTV....spDc....IDF.EpThtpLhpIppptKslCLIGsPaFlYLLsp..a..hK-psIp.FpuGpchaIIT.GGGWKppps-u.....LcRt-FNphLh-sFpL.s.sQIRDTF...NQsELNTCFFED...php++....HVPPW..VaARALDPcTLcPlsc.Gp.GLhSYMDASuTSYPuF....IV.TDDIG.Ilcc..pps-..asGspVEIlRRlpTRttKGCulSMspshp	...................................................................................h....................................t....htthhhp.htap...appst.Y.+paspt....t.hs.....tpl.....ps...lp-...I..PhlP...lph...FK........t...tpl.h.oh.s......p.p..p.l.p.t.h.h.p.SS.G.T.....o..G......h...t...S..p...h.hh......D.p......s.ht.t.....t..s..hth..hh..p......h...h..t.....p..t....h.t.h..ls...h..t..P.s..........p.t..s.s..h.h.h.p......h.h.h....hs.....hh.......hs..sp.....ahl.......ptp.t..........h.c.h..pthhttl...p..tt..pspslhlhG.sh.hh..ah.h.h....h...hccp..shp...h.pl...s...t.s.shlhc.sGGaKthppc......ls+pphpphltpshGl.....pphhsha...s.sE..h...s....hhcs...........sttth............p..s..P..sa....l..h..hR.....D.s.p.s.h...p.s.hs.....G..c.h.........Gllphhshhsh.s.suh....ll.T.-DlG.hltt....ss.....s.h........FcllGRh.ptu-h+GCu..........h....................................................................................................	1	47	90	108
+3247	PF02664	LuxS		S-Ribosylhomocysteinase (LuxS)	Bashton M, Bateman A, Adamkewicz J	anon	COG1854	Family	This family consists of the LuxS protein involved in autoinducer AI2  synthesis and its hypothetical relatives. S-ribosylhomocysteinase (LuxS) catalyses the cleavage of the thioether bond in S-ribosylhomocysteine (SRH) to produce homocysteine and 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of type II bacterial quorum sensing molecule. 	20.20	20.20	21.00	21.00	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.67	5	2731	2012-10-02 15:41:56	2003-04-07 12:59:11	10	2	2619	23	302	1250	26	152.40	46	95.62	CHANGED	Ppl-SFslDHTKlsAPhVR.lAc+KsTscGDlITsFDlRFCtPNKE.lMcscuIHTLEHLhAshlRNHtN.hssh-IIDISPMGCRTGFYLollGcPspp-llDllcsoMpDVLclp-..pIPuuN-KQCGsYppHoLEsA+clARsaLs+..tI...KsEpLcls	..........................l-SFplDHT+hpAPhVR.lApphpsP.+G..DsIosFDlRFstPN+-.hhsptGlHTLEHLhAshhRsHls.u...clIDlSPMGCRTGFYhslh.Gp...s..sppclscshcsuhcD.lL.p..s..p...s...clPthN..hQCGsYp.HSLptApph.A+plLpp...tl...ps-.....s.............	1	74	166	239
+3248	PF00206	Lyase_1	lyase_1; 	Lyase	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	21.20	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.71	0.70	-5.24	18	16439	2009-01-15 18:05:59	2003-04-07 12:59:11	15	45	5117	204	4142	12313	9223	297.30	26	66.01	CHANGED	GchssssDthhuhhopcsh.sh+lst.s.p.......uhshhp+AtApssh.h....pctssuIhpuh-clhc.schscpFslsshppsssTssphplsElIu.......t.........csss+VppupSoNDshsTuh+lhhtpslpp.LlstLppLhpslsc+AcpatDllhhGRTHLQcApPlTlGpchpuasttlpc-hpRlppsh.chhhtshsGGsusGTulNsc..ch..hlsccLu...hou....sssNph-Alus+DtllEhhuslshlsspLtKh.ApDlplhuSG..sGhsElshstsp...GSSlMPtKhNPsssEh...lpthuspVhG	.............................................................................................................ht...ssthhth.o..t..ps..h.....p..h.....h.....lt......ph.............s.hhh..t.p.u..huth.sh..............................tp.sp.tlh...p.u.h..c.p...l..h..p.....h.p......h..t.........t....t....h....l...p.h.h.p..p.s.......s...t....p.....s..s...p...h...p......l.s.E.h..lu........................................................p.s..sc.clphup.So.........NDh.....h..s.Tuhp...lhhtpsl.chlhst....l.p.p.L.h.psltppAp....pa......p..c..hl.....hhGRT..H.h....Q..c...A.pPhThGpchtuas..t.l.p+...s.hp....+.lppsh....p.h.............h.h....t.h..ht.G....u.s...u......s.........G.....T......u........h.............s.......h........s.....................t.....................t...........h.s..s..c....pLu...................h..s.s.....................s.t.s.........h..h.........p...s..l....s....s+.D.h.h......s..c.....h....h..u.....s.lshlu....s..pLp+lupDlhh.hsos...huhs.El.s......h.st.s.p...G.SSl.MP.t.......K.hNPs.hsEh.....lpthshplhG..............................................	0	1294	2586	3471
+3249	PF02278	Lyase_8		Polysaccharide lyase family 8, super-sandwich domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_4840 (release 5.2)	Family	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	20.00	20.00	23.30	20.40	19.40	18.90	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.84	0.70	-5.03	5	1067	2012-10-02 23:57:29	2003-04-07 12:59:11	13	57	784	47	126	780	15	260.60	32	28.72	CHANGED	scP..stL+tFNsMDRlsaaNt-huFuFGLSMsSKRTt+YEuhNcENhRGWYTGDGMhYLYN..oDssHYoDtFWPTV-hYKlPGTTspDs+psDs.Tc-.............tpsss.oscauGo.KlDDpaAuuuMDFcNhscTLTA+KSWFhLcDKIVFLGoGIpsTsssssssTTIDsRK.tsssuYssYsscKphohscup.....-spSVFLESa-s++NIGYaFhcsusIolp+csQTGsWp-IN.sSpocccVos-ahTloQcHusc..sssYGYhllPGlsRssFs	............................s.....p.hpha.spMD+hshhp...t.....s..auhuLShhSpR..ltsYE......t.h..N.s.E.Nh+GWaTusGMhY.LYs.....sD..h.s.c...Y.....p-....s..a....W..s..T...sD.h+lPGTTs....h....s...s...p...hs..cs....sss........................................t.t..hps...p...s..huGu....ph....s.s.......p..h.us.h...u.....M.......c..a......s...............s............................s...........p..............o................L....s..A.....+......KSWFhLsDcI.l.h.LGosI...p.........s..s.s.......s........p...s..s...............t.To.l.-.p....R+................s.ssh.pl..h.s..s.s....t.p.h..s...s..p..pp...............................psp...l.h..h....p....s......t..s...s..p...p..s..l.G...Y.a..F.h.p..p.....s.....s.......l.sh.p.pppp.......pGpWp..-I..N.....p..u...p....s....s....c......p....h......pspahplt.sHsps.......sspYuYhllPshspt........................................................................................................	2	69	106	120
+3250	PF02884	Lyase_8_C		Polysaccharide lyase family 8, C-terminal beta-sandwich domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_4840 (release 5.2)	Domain	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	20.20	20.20	20.20	20.20	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.06	0.72	-3.96	29	875	2009-01-15 18:05:59	2003-04-07 12:59:11	12	50	698	45	82	585	8	76.70	25	8.46	CHANGED	lplLpNssphQuVpcsp........slhussFa.ssu......psst...lssspsuslhl+cpsss.hplslu-Pspsssshp...............plh	.........................hpllcNscslQuVccsc........slhuhsha..ssust........pssp.....l.pl.p....ptu..hhhl.+......cp..ssp..hcluhh.sPppppss.s...hh...........................	0	46	68	79
+3251	PF00062	Lys	lys; 	C-type lysozyme/alpha-lactalbumin family	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.91	0.71	-4.14	21	1035	2012-10-03 00:09:25	2003-04-07 12:59:11	15	9	315	768	356	1346	9	110.30	37	77.66	CHANGED	KhasRCELu+pLKt.GhDGYpGlSLusWlChspaESuYsTpAhspN..ssSTDYGIFQINs+aWCscucTPtupNhCsIsCspLL-DDITcslpCAK+Il.DspGlssWlAW+shCp.cDLspa.tsC	...................................................................hhpRCELActLp.t...shs.att.pLssW.l.Cls.aESuasTpshs.......tss...sG.S.s-Y...GlFQINs+aWCp...s...sp..h.......s.......t.............shCpl.sCs...t.L...Lsc-lscsltC.A+p.Ih.p.....t.......p.......G.......h.......puW..........sWpt.hCp...pplsph.ttC..................................................................	0	50	75	177
+3252	PF01810	LysE		LysE type translocator	Bashton M, Bateman A	anon	Pfam-B_1537 (release 4.2) & Pfam-B_7916 (Release 8.0)	Family	This family consists of various hypothetical proteins and an l-lysine exporter LysE Swiss:P94633 from Corynebacterium glutamicum which is proposed  to be the first of a novel family of translocators [1]. LysE exports l-lysine from the cell into the surrounding medium and is predicted to span the membrane six times [1]. The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances or peptide hydrolysis; and also after artificial deregulation of  l-Lysine biosynthesis as used by the biotechnology. industry for the production of l-lysine [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.14	0.71	-5.02	19	13176	2012-10-03 02:02:08	2003-04-07 12:59:11	13	5	2968	0	3080	9500	5031	188.60	20	91.83	CHANGED	lshhhsPGPsshhlhppulp+uhttulhsshGshluDhlhhhlshhGluhllt.sshhhsllthhGusaLhahGhtshRsshpsps.pt..........................tssp.........thhpsahpGlhloLsNPpslLaahulhushls....tht.hthhhhhsuhhlusl.lWhhhluhhsuhhthhhpt.th...hlshlsuslh...................hhFulhLlhpu	...............................h..hhlsPGPss.h.hlhpp....u.l......p.....p.G.....h...p.tuh....hs....shG.h.sh.G.....h...l...h...h...h.hu...s...h...G...l..us...l..lt...t...s.s.h......l.h.p...l...l..ph....s.G...u....s..YL....l....a..lG....h...p.h....h.....+....u........s.......h...p.....t.....p...t...t...t.t..................................................................................t.tst...................shhp..h..a.hp..uh...hss...l.h.N.....PK.s..h...l.a.h...lu.l...h...s..p..h..lss.....................t..s..h...h....t...h....h....h......h.....s..h...s......h.....h.....h.......s.....s....h......h....a....h.....h......h......h....u.......h....h....u...s...h....h......t....t....h....h...p....p....t....p.hh......phl.s...t.l..h.G.s.lh...................h..h.huhhlh...t........................................................................	0	649	1498	2340
+3253	PF03641	Lysine_decarbox		Possible lysine decarboxylase	Bateman A	anon	Pfam-B_741 (release 7.0)	Family	The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.77	0.71	-4.34	32	5042	2012-10-01 21:16:48	2003-04-07 12:59:11	9	29	3532	56	1524	3863	1410	131.70	28	49.24	CHANGED	Msslscush..cuGup........slGlhsphlhs.pchs........................sptls-l..lhhpshapRKthhschu-AFlshPGGhGThEElhEllThhQlGhc...p+.PllLhs.su...aacsLhpalc.phlppGhlsssstp.hhhhsssscplhptl	...........................................................Mtusscush.......cu.u.u.p...........slGl..h....shlls...p.chs.......................................................ss...h..l...s...c..l.......lh..h..p..s..h..p.p..RKt.hhs........c........h........u........c.u.h.....lsh.P.........GG.hGT.......l-El.hEhloh..hQh.shp.....................pp...P..l...l.Lhs.st..........aaps.L.h.pa..l...p..thh..t.p..u...h...lstpshp..hhhls-ssp-lhp..................................................	0	441	972	1290
+3254	PF02402	Lysis_col		Lysis protein	Mian N, Bateman A	anon	Pfam-B_1555 (release 5.4)	Family	These small bacterial proteins are required for colicin release and partial cell lysis. This family contains lysis proteins for several different forms of colicin. Swiss:Q02112 has been included in this family, the similarity is not highly significant, however it is also a short protein, that is involved in secretion of other proteins (Bateman A pers. obs.). This family includes a signal peptide motif and a lipid attachment site.	25.00	25.00	57.10	57.00	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.32	0.72	-4.38	9	52	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	28	0	2	37	0	45.10	67	96.50	CHANGED	MK..Klhhhhlllls.hhLuACQANYIRDVQGGTVAPSSSucLTGlulQ	..MK..KlhhlhlLllu..hhlLuACQANYIRDVQGGTVuPSSSuELTGlusQ.	0	0	0	2
+3255	PF04971	Lysis_S		Lysis protein S 	Finn RD	anon	Pfam-B_7633 (release 7.0)	Family	The lysis S protein is a cytotoxic protein forming holes in membranes causing cell lysis. The action of Lysis S is independent of the  proportion of acidic phospholipids in the membrane [1].	20.70	20.70	20.80	21.00	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.17	0.72	-4.29	7	1200	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	353	0	16	366	0	66.40	84	94.47	CHANGED	M-KITTGVuYsTSAsusGYWFLQhLD+VSPSQWAAIGVLGSLlFGLLTYLTNLYFKI+EDRRKAARGE	....................................MEKITTG...VSY.sTSAsGTGYWhLQLLDKVS.PSQWuAIGVLGSLlFGLLTYLTNLYFKI+ED+RKAARGE..................	1	2	5	9
+3256	PF01186	Lysyl_oxidase		Lysyl oxidase 	Finn RD, Bateman A	anon	Prosite	Family	\N	20.30	20.30	20.30	21.50	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.49	0.71	-4.70	4	515	2009-01-15 18:05:59	2003-04-07 12:59:11	12	16	109	0	231	428	15	188.90	54	36.67	CHANGED	PDLV.DsthVQtosYlpctsLa.LpCAAEENCLASSAhRssshsYspRhLLRFspRl+N.GpADFhPptsRaSWpWHpCHpHYHSMD.FoHYDLLsssus.KVAEGHKASFCLEDTpCs.GhhKRYACssa.pQGlSsGCaDTYptDIDCQWIDITDV+PGNYILpVpVNPsa.VsESDFoNNlhRCsh+YsG++laspsC+Iusu	...................................................................PDLV.cs.hlQto....sYlpchsha.LpCAt.EENCLu...u.....SAh..p....s....p...........h.s.....Y..s....hRhLLRFsppl+NtGpuD.F...h...P..p.tsR..asW.WHpC..H..p...HYH.SM-.FoHYDLLshssp.....KVAEGHKASFCLEDT.p.....C...........c.....Gh...p+..........R.............Y.........s..........C.s.s.....a..............p...Q.G.......losGCaDTYptDIDCQWIDITDVp.P.G.s.Y.ILp...............VslN..P....papVsESDaoNNsh+Cph...+YsGp....h..h..h..h.sCphs...............................	0	40	63	139
+3257	PF02401	LYTB		LytB protein	Mian N, Bateman A	anon	Pfam-B_1515 (release 5.4)	Family	The mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis is essential in many eubacteria, plants, and the malaria parasite. The LytB gene is involved in the trunk line of the MEP pathway.	18.70	18.70	19.10	19.20	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.86	0.70	-5.49	13	3664	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	3349	24	911	2662	2891	277.30	42	82.28	CHANGED	IlLApPRGFCuGVcRAIphsEpA.Lppttu.PlYlpppIVHNppVVspL.RpcGshFlEsl........p-lP..........cGshVIaoAHGVuspVcptAccRsLpllDATCPhVTKVHptspphu+cGaclILIG+csHsEVhGshG.ss.........................spshlVpshc-ltpLshps.p+luhloQTTloh--st-IlstLccRascltt.........spssIChATpsRQcAl+sLutcsD.lllVVGupNSSNSsRLhElApcpGs.suaLl-ss-.................-lpt-Whpssp.slGlTAGASTP-hllpsVlp+Lpph	..............................................llLAsPRGFCAGV-RAIp....l.......V..Ep.....A........L.........c.........h.....a.............s.............s....PlYV++ElVHN+a.....VV-sL.c.p.+.G.sl..F..l...-..cl..........s-lP.......................................cs.s..h.VIFSAHGVo.sVppcAc.p......R....s.L..p..l..h..DATCPLV.......T....KVHhcl....t....+............h......sc...........c......G...........h....clllIGH.t.GHPEVcGThGphs........................................sth.h...L....V.......-.......s...s.....-.....D.......l.........t.........p.........L.......p.........l....p....s.........p..c..lshloQTTLSlD-Ttc.llctL.+p..+..a.P.p.lhs...............................Ph.pc-ICYATpNR.QcAV.......+.p..l....A.....p..p.......s......D.....lllVVG.upNS.SNSsRLhElA.pc................h.......Gt....su.aLl-ssp.................................-l....p....p..Wl.....p.....s.....s...p......sl..GlTA.....GASsP-hLVppVlsplpt.h...............................	1	319	613	776
+3258	PF04397	LytTR		LytTr DNA-binding domain	Yeats C	anon	[1]	Domain	This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern (see [1]). 	21.50	21.50	21.50	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.83	0.72	-3.92	114	8937	2009-09-11 13:50:36	2003-04-07 12:59:11	10	26	2937	3	1808	6179	571	96.10	22	42.29	CHANGED	sphhhlshp-Ihal..ps.pschlplhst.....spphhh.ptoLpplcpcls..stFhRsHRShlVNlppIpclp.......t..ph..plhhps.....spplslSRphhcpl+phlt	............................................p..hhhlshp-Ih.ah........ps...p.....s...c..hl...h....l...hop............sp....p....h....h.h....p..h.....s.L.p.....p.....l.c...p.....p.....L....s........pp.......F.h.RsH+Sa.lVNhp.plpplc..........................ph...pl....h..lps.............sppl..l..SRphhcpl+phh.t...........................	0	766	1373	1637
+3259	PF02370	M		M protein repeat	Bateman A	anon	Pfam-B_208 (release 5.2)	Repeat	This short repeat is found in multiple copies in bacterial M proteins. The M proteins bind to IgA and are closely associated with virulence. The M protein has been postulated to be a major group A Streptococcal (GAS) virulence factor because of its contribution to the bacterial resistance to opsonophagocytosis [1].	20.80	15.60	20.80	15.60	20.70	15.50	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-7.31	0.75	-7.27	0.75	-2.86	59	653	2009-09-11 13:49:06	2003-04-07 12:59:11	11	24	24	1	3	651	0	21.10	53	14.87	CHANGED	ptK+plEuchpcLppcpptlc	..EAKKclEA-htcLpp-pQh.c..............	0	0	0	0
+3260	PF03855	M-factor		M-factor	Finn RD	anon	DOMO:DM08003;	Family	The M-factor is a pheromone produce upon nitrogen starvation.  The production of M-factor is increased by the pheromone signal. The protein undergoes post-translational modification, to remove the C-terminal signal peptide, the carboxy-terminal cysteine residue is carboxy-methylated  and S-alkylated, with a farnesyl residue [1].	25.00	25.00	28.40	83.80	22.30	16.60	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.19	0.72	-3.97	2	3	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1	0	3	3	0	42.30	72	100.00	CHANGED	MDShAssspSSSlVNAhNp.Ps-slp.pslKNYTPKVPYMCVIA	MDSMANoVpSSSVVNAGNK.PoETLN.KTVKNYTPKVPYMCVIA	0	3	3	3
+3261	PF05034	MAAL_N	MAAL; 	Methylaspartate ammonia-lyase N-terminus	Bateman A, Moxon SJ	anon	COG3799	Family	Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the N-terminal region of Methylaspartate ammonia-lyase. This domain is structurally related to Pfam:PF03952 [2]. This domain is associated with the catalytic domain Pfam:PF07476.	21.00	21.00	21.40	36.90	20.00	18.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.79	0.71	-4.46	4	186	2012-10-02 11:54:41	2003-04-07 12:59:11	8	4	173	12	42	142	2	155.20	62	38.70	CHANGED	M+IccVLhTPGhuuFaFDDQtAI+sGAspDGFsYsGsPsTsGFpplRpsGEulSVtLVLpDGpVshGDCAAVQYSGAGGRDPLFhApcahsllpctltPtLlGRDlssahssAthh-ch.lstptLHTAlRYGlSQALLcAsAtsptsThsEVlsDEash	..MKIKpslhTsGhouFYFDDQpAIKsGAsHDGFhY.sGcPVTtGFsuVRQAGEslSVtLILEsGuVAhGDCuAVQYSGAGGRDPLFLA-cFIPhlpccI+PhLlGRDlcuFhssAchFDcL...+l.........D...Gp.hLHTAlRYGlSQALLDAsAhAs.s+hhsEVVsDEap................	0	16	27	36
+3262	PF03281	Mab-21		Mab-21 protein	Mifsud W	anon	Pfam-B_4530 (release 6.5)	Family	This family contains Mab-21 and Mab-21 like proteins.  In C. elegans these proteins are required for several aspects of embryonic development [2-3].	20.10	20.10	21.30	20.50	19.10	19.80	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.92	0.70	-5.28	33	746	2012-10-02 22:47:23	2003-04-07 12:59:11	9	9	110	0	456	647	1	241.40	20	57.39	CHANGED	uhh-slcltssscach.........hh.lpt.shhp...................hppptphsshshl+l.............................hps.phhpcals........................tsshlssp+lhstFt.sllppu...............................lsphphps............h.phttpssslpltlppt.........thslDllsulch.shWPp.u.pa.hh.............phWPs.thhpplts..pGhaLls+.........................................tshsshpWRlSFopuEptLhpph............sss++cClpllKtlpcphh...........hsslsoYHLKTllhapC-+hPpt..pWpp.sslupplhsllccLhpCL....ps+plPHYFlP.....phNLhpsh..spstlpphspplhclhp	......................................................................................................................................................................................................................................................................................................................................phh................................................................................................t.hhsst...phhphh..ph..lt.s..................................................h.p..t.t.................t...ts....hpl.ht.............h.hplhPshph...........t................................................sh.Llst.......................................t..t.t.pss.tWhluFstsEptllp.h............sus+.hpsLpl....h..+s..l.tcpth.............................thtsls.sYHL.+ollh..ahspch...st....p....Wpp......ptlupph.tll.tLhpsL....................ppcp..hspaahs..................phshhpth....tth..hh........t...............................................	0	90	123	236
+3263	PF01823	MACPF		MAC/Perforin domain	SMART	anon	SMART	Domain	The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerisation of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerises into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin.  The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (Pfam:PF01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold [1]. 	20.70	20.70	20.80	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.30	0.70	-4.64	69	1344	2012-10-01 20:08:01	2003-04-07 12:59:11	14	63	273	9	771	1199	5	197.40	16	29.28	CHANGED	hshsssspa.pph........phpppppphhhtpspsphhphph...ts.ph........LsppF.....hptlppLPsp.as.sp.............................ahphhcpaGTHhlspsphGGphthhhph.......spsplpptphpttc............hssthth.h..................thphptstpspppppppp..s......ppthppthshlhGGss................tsspsappWtpolpp.pP.ssIphp.....................................lhPl....ppLlpp...............tppslppAl...ppY	.........................................................................................t.......th.pt..........t.tppp.p..h....h....h...th...h...p....hh.p.hph........p.pph..................LstpF.....hptlpp.L....sp.p...h.s.st...........................................h..phl.ppYGTHal.ss.ss.h..........G.......Gphphhhhh........................sppp...hp.p.pthptt.p...................hpht.hth.h..............................ht.p.hstp....tt....t..p......tt....t......................................pt....p.h....hh...GGp.................................thppW...hpolt........t..tP...hlp..h.p....................................................h.Plhpll.....................ht..hptAh...........................................................................................	1	245	380	547
+3264	PF03523	Macscav_rec		Macrophage scavenger receptor	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	45.90	44.70	23.80	18.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.30	0.72	-4.21	4	55	2009-09-11 06:31:35	2003-04-07 12:59:11	8	6	27	0	17	49	0	48.90	75	13.96	CHANGED	MEcRIQ.ISDocANLlDoE+FQNFShTTDQRhNDVLLQLNSLlsolQtH	....MEKRIQaISDhEANLIDoEHFQNFSMsTDQRFNDlLLQLSTLhSSVQGH..	0	1	1	2
+3265	PF03817	MadL		Malonate transporter MadL subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	27.90	27.70	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.67	0.71	-4.27	4	182	2009-09-11 09:12:09	2003-04-07 12:59:11	8	1	176	0	51	151	39	121.60	57	91.51	CHANGED	MIIYGVALLulCpLsGlhlGshLGshLGVKANVGGVGIAMlLLIhspphLtK+GtLsphop.GVtFWuAMYIPIVVAMAApQNVluALsGG.lALLAuluAllVshhhIslls+.u..puph.sAlE	.MIIYGsALLAlCpLAGlhlGDlLGshlGVKuNVGGVGIAMlLLIhh+haLp++Gh.hspcoEtGVuFWuAMYIPlVVAMAApQNVVuALpGGPlAlLAuluuVslCsssIslLuRhu..+tps.....t................	0	9	20	35
+3266	PF03818	MadM		Malonate/sodium symporter MadM subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	59.60	59.60	20.50	19.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.77	0.72	-4.40	4	185	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	183	0	51	137	41	59.80	57	23.68	CHANGED	a-.lsssLspNGLITuFAllGlhMaVSahLSthLT+G+lHGSAIAIhlGLVLAYVGGssT	......-hlpKsls+NGLlouFAlVGllMalSshLS++LThGRVHGSAIAIlIGLlLAYhGGshT...	0	9	20	35
+3267	PF02545	Maf		Maf-like protein	Mian N, Bateman A	anon	COGs	Domain	Maf is a putative inhibitor of septum formation [1] in eukaryotes,  bacteria, and archaea.	19.40	19.40	19.60	19.70	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.13	0.71	-5.19	12	5338	2012-10-01 20:37:09	2003-04-07 12:59:11	9	24	3690	6	1449	4011	3017	188.60	33	91.91	CHANGED	h.llLASsSPtRpplLcpht..lshpshsuph-Ep.....tp..PtthshcLAppKAhu.luphtss...........sllluADTllhls.GclhsKPpst-cAhphL+phuGps...tpVhTulslhpptp.hpsh.....s.TcVpFpp.lscccIpsYlpos-slcpAGuaslpGhGuhhlcplcG.sh.sVhGLPl.tlhphLpphsh.........hts.h	..............................................................h.pllLASsSPtRp..pL.L.p.p.l......G.........l.s...........F.p.h....h.........s.........s........c.......l........D.Es................h.s...-.......t.........................P......p........p...h...........V...h.....+.....LApt.K.A.p..u..........l.s..p.h..hss......................................................tlllGuD.ol........l.s..............l.................s.....G..........c.......l....lG.KP......pstc...cAtp.....hLp......t......h.......S.G..pp...........apl..hT..u..l....s..l...h.....s...s....p.....p..t....htph......................shocVpF+p....Lo...-p...-...I...p...s....Ylt..s..s...-..P..h..c.pA..Guasl..p.G.h.G.s.t.h.l.cc.l.p..........G..shpsllGLPLhphh.ph.Lpp.s........t..................................................	2	469	903	1204
+3268	PF02792	Mago_nashi		Mago nashi protein	Bateman A	anon	Bateman A	Family	This family was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [3]. The human homologue has been shown to interact with an RNA binding protein Swiss:Q9Y5S9 [1]. An RNAi knockout of the C. elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination [2]. Mago nashi has been found to be part of the exon-exon junction complex that binds 20 nucleotides upstream of exon-exon junctions [4].	20.10	20.10	22.60	22.10	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.64	0.71	-4.50	3	383	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	275	17	226	307	1	132.20	69	83.18	CHANGED	DFYVRYYVGHKGKFGHEFLEFEFRsDGpLRYANNSNYKNDTlIRKEsFVSEuVLKElKRIV-DSEIlKEDD-NWPEPDKlGKQELEIlhsNEHISFsTuKIGSLADVQNScDPEGLRlFYYLVQDLKCLVFSLISLHFKIKPI	...........................................................pFYLRYY...lGH+.............GKFG.HEFL...EFEFR.....s..DG.....+...LRYAN..N....SNYKNDshIR...KEs..aV.ppuVhcE.lKRII.c-....SE........I..hK.......EDDshWP.PD+..l.GRQELEIllGsE......HISFTTo.KIGSLlDVspScDPEGLRlFYYLVQ.DLKCLVFSLIuLHFKIKPI.......................	0	80	120	175
+3269	PF03082	MAGSP		Male accessory gland secretory protein	Bateman A	anon	Pfam-B_256 (release 6.4)	Family	The accessory gland of male insects is a genital tissue that secretes many components of the ejaculatory fluid, some of which affect the female's receptivity to courtship and her rate of oviposition.  This protein is expressed exclusively in the male accessory glands of adult Drosophila melanogaster. The proteins are transferred to the female fly during copulation and are rapidly altered in the female genital tract [1].	25.00	25.00	115.50	47.80	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.82	0.70	-5.00	2	35	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	7	0	1	123	0	235.40	77	99.83	CHANGED	MNQILLCS.ILLLhFTVAsCDuEpQLDSuhcL.....KSAsLKNVAPKNstTQAcIsKDDVALKsuKKGDYlMDI-lSDhPLDDYPINpSKShKsSSh..ssI.....LsD....chNQGSNQ.ALKALppRLlhEQNNsLhLRNHSl.LMpEIEARKTDIIpsRQLNlDLELELpolpR+L.EhN..lQNsRKSTKsCKKRsSKD.APP.sNQhQEs.V+NTYRNKYLTLLppLuQKIN.EIApV...ATDVPTtpsPSpGN.sTh	...................LhFsVANCDGEHQLDSSl.D..L..K.S.DppKSAVLKNVAsKNDATQAEIAKDsVALKSGKKGDYVMDI-.V.SDMPLDDYPINNSKSRKNSSTLPSP.I.....LTD....KLNQGSNQIALKALKHRLVMEQNNNLFLRNHSVSLMNEIEARKTDIIQARQLNIDLELELEALKRKLSEMN..VQNARKSTKSC.KKRPSKDIAPP.sNQLQEVIVKNTYRNKYLTLLTQLAQKINYEIANVNNPATDVPTGKSPSEGNPSTT...................	0	1	1	1
+3270	PF04112	Mak10		Mak10 subunit, NatC N(alpha)-terminal acetyltransferase	Wood V, Finn RD	anon	Pfam-B_9176 (release 7.3);	Family	NatC N(alpha)-terminal acetyltransferases contains Mak10p,  Mak31p and Mak3p subunits.  All three subunits are associated  with each other to form the active complex [1].  	20.70	20.70	20.80	22.90	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-5.03	18	303	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	263	0	218	301	3	149.50	30	21.95	CHANGED	+sGcLV+-spFsLF-uhuAlEIh-sKMDoGhlt.s.pt....tlcpuhssu.........pslshtclluIhDpLhss.huWhpGa.oLuQTVhoClYlcpl......t...t.............................ssplhcpVLpuaslulhphhshltshlpsutlaEE..EDhsspshshshhsphs.htchhshL	........................GcLl+st.h.FsLFEuhuAlE........lMDPKMDuGhlsst.p.......th-p.shcss....................csLs.tElluIhDplhsp.hsWhpGa.sLuQTlaTslYl..cp..............................................................sp.l.p.sL+....uashulh+hsshspphlspsthaE..E..E.DF.s.shshp..hhsphs...h....h...........................................................	0	77	120	182
+3271	PF04874	Mak16		Mak16 protein C-terminal region	Mifsud W	anon	Pfam-B_4960 (release 7.6)	Family	The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus [1].	20.30	20.30	20.30	21.30	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.49	0.72	-3.93	9	337	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	299	0	235	325	3	98.70	42	33.08	CHANGED	lspKlc+REppREcKALlAA+L-+sIE+ELl-RLKpGsYGD..aNhsppsacKhL-tcc.cppsEtE.-....p-Ep--uchEaVuDp..-..t...-lpDhED	.....................h.spKlcRREppREcKALsAA+lEpuIEKELLERL+p.Gs.YG...Dh..........h.....Nh.....spphacKsL........c..............p.......p.-...........................c............p............p...........s.........c......p.......-....t........-...............c..........t......-.......-........-....-.........E..c..-....................s..ch.....Ea..V..p.D...t-.ptp..-hp.D.hE.............................................................	1	82	130	195
+3272	PF01274	Malate_synthase		Malate synthase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	\N	20.00	20.00	20.00	20.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.84	0.70	-6.50	16	2722	2012-10-10 15:06:27	2003-04-07 12:59:11	17	11	2102	17	690	2600	3654	522.80	38	94.48	CHANGED	hslhsshs.ptscILTpcALsFlApL.pRcFsspp+pLLppRpchQtclDpGp.hs..........cFL.PETsalR.-ssWps.us.......................................................................................................................................lsssLtDR+VEITGPsD.RKMllNALNouAhsaMADFEDSsuP...........oWpNllpGQlNLpDAlcspIsapst.tsKpYpLs.......cphuhLhVRPRGWHLsE+Hlh.lDG.....-slsGu...lhDF...GLaFFHNt+ph.......lupGtGPYFYLPKMEuahEA+lWN-lFshApDhlGlPRGTI+ATVLIETlsAuapM-EIlYpLR-HuuGLNCGRWDYlFShIKshpsp.sshlLPDRstVTMssP....FMpAYschLlcTCH+RusaAhGGMAApIPI+cD.tANstAh-pV+tDKlREspsGaDGoWVAHPuLsslshpsFpphh.spPNQhphh+pc...plo....tsDLLs.thPsu.......phTpcGlcsNlplGlpYltAWL.pGlGC..VPlhp...LMEDAATAEISRsQlWQWl+HGVshc-....Gcplohphhtpll.cEphstlt.t.u....tsscap.Atphh.t.sh.uscasDFLTh.uYscls	.............................................................................................................h..hht..s..tptl.s.sphhphlspl.hpchsPcppp.L..LstRtphQtplDthp..hs...................sFL..pE..hs.lh..-.......ssh..hh..ts....................................................................................................................................................l....h-Lp.cp......s...ch..sG..s..s.-.t.........t.hlhs...s....l.sts.shshht.DhED....SlAs....................sW.slhp.Gplshp.....suhsGph....hp....s......s.s+.Yp.ht...............tshulLhlRshGaHhscpplh...hcG.........ptlsuu...lhDh......uLhh.h..Hshpsh.................u+..u.uusYhYlPK.........h........cu.pEAthWs-l......FshsE......chlGls..........p.GT.IKsslLlEpl.Ashphc......EllatlR-+lstlNs.GhhDhhhs..I+ohhpt.ss.hl...Rps...shhs.pP....alpAYpch....lpo..............................hh..huGhu.uh.h......ht..ps....................s...sphhs..chhtsKhtcspsGt......sssWVsp.PshAsh.ththapph......spssQhpl........tppp.....h.hs..........hcp.....LLs.....s..u...............pchp.ptlcsNlpshl.........tYl.tWl.pGs.GC..VP.hs...........LM.EDtAThcISppplhpWl+H.t...........h.s...hp..s...............h..........sohphht....phl.spp.t...................................spsta..p.h...........usph.s.lsh.uhp.l.................................................................................................................................	1	193	413	579
+3273	PF02330	MAM33		Mitochondrial glycoprotein	Mian N, Bateman A	anon	Pfam-B_17905 (release 5.2)	Domain	This mitochondrial matrix protein family contains members of the MAM33 family which bind to the globular 'heads' of C1Q.  It is thought to be involved in mitochondrial oxidative phosphorylation and in nucleus-mitochondrion interactions [1].	20.90	20.90	21.40	21.50	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.39	0.71	-4.56	7	515	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	299	14	330	513	1	177.80	22	68.50	CHANGED	LssEIc.E+c.th........pcsLs.hsh..shc.pssssEscLh+Ks.uuEcIpVsFNlspsls.sass-p-.spht...-pp.p.sssssh.s.ssppD.s.h.shsl-hphPtsp.lsacspA.....psDh..Fslc-h.htsou-s........EW..c...as.shcsLD.sLhD.thhcaLt-RGlDsshuc.LVphusshE+pEYIsaLEclKpFl	.........................................................................................................................................................Eh.......t.............................h...t............th.....p.sttth.Lh+ph.....tsEplpl.h...p.....hs...p..................................t...t.....t........t.......t...................................t..........................................................h...........h....s..l.sh..p..c.s..s..ps....lph.ps.sh............................ss........htIcpls..h.h.tp.sp..................t-h.......tt.h.....Yh...GPsassLD-pLpc.tlhcaLc.cRGlssphusal.cahphKEppEYlpWLc....slcpFl.................................................	0	97	176	265
+3274	PF02157	Man-6-P_recep		Mannose-6-phosphate receptor	Mian N, Bateman A	anon	IPR000296	Family	This family includes both Cation-dependent and cation independent mannose-6-phosphate receptors.	20.40	20.40	20.50	20.40	19.50	19.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.98	0.70	-5.39	2	195	2012-10-02 14:19:21	2003-04-07 12:59:11	10	3	147	24	129	261	1	170.90	29	61.70	CHANGED	M.PhpusWRTtLLLLLLhuVAVRESWQhEEKoCDLVGEKsKEScpElALLcRLpPLFNKSFESTVGQusDhYSYlFRVCREAuNHSSGAGLVQINKSNsKETVVGRhNETpIFNGSNWIMLIYKGGDEYDNHCG+EQRRAVVMISCNRHTLAsNFNPVSEERGKVQDCFYLFEMDSSLACSPElSHLSVGSILLVhhASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM	......................................................................................................................................................................................................................................................................................................................................................+p...t...h...h...Cs....p.p.......t........h...hs..p....p.p.ChY..hFEh.c......S........thAC.........s...s.......t..t....s.....p.....l..u.....s..G....u..l...h.h.llh.hhh.ls..VYl.l....GGhhYpRhVhtt+GhcQhPphuhW.tslhshh..t..D.hh.h..h......................................................................................	0	39	63	100
+3275	PF01232	Mannitol_dh	Mannitol_dh_N; 	Mannitol dehydrogenase Rossmann domain	Bateman A	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.86	0.71	-4.27	16	4952	2012-10-10 17:06:42	2003-04-07 12:59:11	18	14	2308	4	770	3058	403	147.30	28	33.49	CHANGED	.phlHhGsGNhtRu....alspLlsp.ssh-hshs-ls.pssst......LptQcphhslltp.......sscpsclluslssh.shpts..psllcthsc..sclVoholst.............sshPpIttslspst............Lp+RpstshsPhslluC-Nh	......................+hlHhGhGshtRua.s.ah..sc.L.Ls.......p.....s....s............h..............c..huhscV.s...hssst.........tL...p.t.Q....c...p.lh.s..h.lht..s.........tps...p...pscll...u.u..Vpt..s....l............s...s......t....p....-........t....t....ll....p.th.sp.stsclVohslTEtG.......ht...ttt..h.....s.s.t....P.h..Istsl.tps.......................................hlhth.lp.+R.p.....t.s.....s.h..p.s.hslluC-Nh..........................................	2	193	431	596
+3276	PF01050	MannoseP_isomer		Mannose-6-phosphate isomerase	Finn RD, Bateman A	anon	Pfam-B_899 (release 3.0)	Family	All of the members of this Pfam entry belong to family 2 of the mannose-6-phosphate isomerases. The type II phosphomannose isomerases are bifunctional  enzymes. This Pfam entry covers the isomerase domain.  The guanosine diphospho-D-mannose pyrophosphorylase domain is in another Pfam entry, see Pfam:PF00483.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.96	0.71	-4.60	17	2703	2012-10-10 13:59:34	2003-04-07 12:59:11	13	9	1834	0	687	2749	2876	136.20	49	31.58	CHANGED	lGlpsLVVVpTcDAlLVuc+ccsQDVKclVcpLKtpsRsE..tphHpcVaRPWGpYcsl-pGcRapVKRITVKPGp+LSlQhH+HRAEHWlVVuGTAcVThspcshlLsENESTYIPhGshHpLENPGKIPLELIEVQSGuYLGEDDIVRhED	..................................................lGlcDlllVpTtDAlLluc+spsQ-VKp........lVp.p.LKtp.s+..p.-......hp....H..pp..la.R..PWG.p.Yc...s.....l.....-.....t.....G.....p.....R.....ap...V..K.....R...I..s.....V.+PG.t.p..L..S.l.Q..h.Ha.H..R..u..E.H...W.l.V.V.s.GT.Ac..VT.h.....s.....s......c............h.l........l.s......c.....N-......S.........h.YIPh..G..shHp.L...cN........P...G.c...l..P.L...c...lI.E....V....Q.oGsY..LsEDDIVRhpD.............................................	0	212	432	567
+3277	PF05007	Mannosyl_trans		Mannosyltransferase (PIG-M)	Moxon SJ	anon	Pfam-B_5638 (release 7.6)	Family	PIG-M has a DXD motif. The DXD motif is found in many glycosyltransferases that utilise nucleotide sugars. It is thought that the motif is involved in the binding of a manganese ion that is required for association of the enzymes with nucleotide sugar substrates [1].	22.00	22.00	22.20	22.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.89	0.70	-4.74	6	328	2012-10-03 03:08:05	2003-04-07 12:59:11	8	8	285	0	238	382	29	248.70	35	61.37	CHANGED	ISTRGNu-ulluhlllhsLaLlpKpp.........hhtAullaG.hulHhKIYPllYslslhL.l.pshtcQ..........oshsphp....pLlsh..t.lhhl..lsoLhoFsusshhhYhhYG.pFL-csYLYHlhRcDhRHNFSsaahLLYLspAsphh..Sphl....tlhAFlPQhlLlhhh.uhpa......hcsLsashFlpTFsFVTaNKVCTSQYFlWYLshLPLlhsp..............h+h.SW++uLsllhLWhhsQuLWLhsAYhLEFpGhNsFh..laLuusLFFlsNsalLtQll	..........................................................................................ISTRGsu-ullssh.lhhhL..a.hl.h.ppc................................hhhAulhhG.luVHhKIYPlIYuhslhh.h.l...tp.p...t.tt.................................sh.hthhh.............ph.hsh..ptlh.hs......hsohh.oFhsls.h..hhYh.hY.G..hpFLpc.sY.LY.H.ls.Rh.DtRHNFSs.Y..h.hl.YL.s.....ss............pt...................u.......l..............................t.hhu...F..l....PQ..ll.L.h.h.h.....l...s.h.th.........................tccLs.h....shF.......h.....QT.hs...FVsF...NK..........VCTSQYFlWYlshLPlhlsp...................................p.h.......s..h.t...p....u..l...h.hl...h..lWhhu...QuhWLh.u.Yh........LEF.Gh.....s.......sF.h...lahuulhFhhsNshlLh.h.......................................................................................................	0	88	140	202
+3278	PF01575	MaoC_dehydratas	MaoC_like;	MaoC like domain	Bashton M, Bateman A	anon	Pfam-B_297 (release 4.0)	Family	The maoC gene is part of a operon with maoA which is involved in the synthesis of monoamine oxidase [1].  The MaoC protein is found to share similarity with a wide variety of enzymes; estradiol 17 beta-dehydrogenase 4, peroxisomal hydratase-dehydrogenase-epimerase, fatty acid synthase beta subunit. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl-CoA hydratase activity [2]. This domain is also present in the NodN nodulation protein N.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.33	0.71	-4.74	32	6997	2012-10-02 20:54:35	2003-04-07 12:59:11	14	82	2642	72	2491	6367	2455	119.40	20	29.77	CHANGED	phst.....hspshptphshslo...............sphthaAhhSGDhNPlHlDst.hAphutFs.ssIsHGhhohuhstthlhpthss........sthtthps+FhssVhsGsplpsphtpsu..hpttt.phhphpsshhsssss	...........................................ht..............t.hslo...................ppc..l.hhaA.......t..h..oGD.h..pP..lH...h...Dsp...hA.p....p.....s.....s.....F......s....p........h..I.s....H....G....h...h....o........h....u...h......h.......s...t..h...h...s..p..t.hs.s...............hsth....s....h...........p..l.+F..h...p..P.V.h..s....G.-.....s.l.p....s.p...h.plhs.....hp.tt...t..............st.t...................................................	0	656	1497	2090
+3279	PF03642	MAP		MAP domain	Bateman A	anon	Pfam-B_1396 (release 7.0)	Family	This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein) Swiss:Q9Z4J2 [1]. The protein has been found in a wide range of extracellular matrix proteins [1].	24.30	24.30	25.40	24.50	23.80	23.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.89	0.72	-3.76	10	1325	2012-10-01 21:38:54	2003-04-07 12:59:11	8	6	160	5	10	373	0	87.10	51	73.35	CHANGED	VPYTIuVNGsSssltScLsFsscpploYpDLssKVKSVLcsDRGIo-c-L+hAKpApYTVaFKNGsKKVVDLKScIaTtNLFsupDIK	.........VPYTIsVNGTSssIhSpLsFspspploYpDLssKVKSVLts-RGIo-hDL+hAKpApYTVaFKNGsKKVlcLKusha.TuNLlsssDIK.......	0	8	8	10
+3280	PF02991	Atg8	MAP1_LC3;	Autophagy protein Atg8 ubiquitin like	Griffiths-Jones SR	anon	Pfam-B_1384 (release 6.4)	Domain	Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity [1]. Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. The yeast proteins are involved in the autophagosome, and Atg8 binds Atg19, via its N-terminus and the C-terminus of Atg19.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.31	0.72	-4.05	9	1011	2012-10-03 10:59:06	2003-04-07 12:59:11	11	11	362	37	573	990	106	100.50	47	79.62	CHANGED	+RptEuc+IRpKYPDRIPVIlEKsspoc.lPslDK+KYLVPuDlTVGQFhalIRKRIpLsP-cAlFlFVss.olPsTushMuslYpcc+DEDGFLYhsYSuEsTFG	....................................................pRptEup+.IR....pKaP-Rl.......P.................VIlE.....+sp...............+..uc....ls.s..l.D...K.....+K.......a.L.V.....P....s..DlT....V...uQF....hal.I..RKRl.........p.............Ls.........s.............E.cAlF.l........F.V.........s..s.....s........l.P....s.........o.u..u........hMuplY-c.cK.D.E.DGFLYlsYSuEssFG......................	0	190	288	420
+3281	PF00414	MAP1B_neuraxin		Neuraxin and MAP1B repeat	Finn RD	anon	Prosite	Repeat	\N	20.60	20.60	22.30	20.60	18.00	20.50	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.94	0.73	-6.21	0.73	-4.33	11	173	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	24	0	75	166	0	16.90	54	3.54	CHANGED	TT+oP-susYsYEptEK	..TT+TP-sSuYSYEpoE+.	0	5	5	10
+3282	PF01124	MAPEG	FLAP;	MAPEG family	Finn RD, Bateman A, Brock T	anon	[1]	Family	This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme  catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.87	0.71	-4.53	319	2722	2009-01-15 18:05:59	2003-04-07 12:59:11	13	15	1609	34	1052	2147	1247	123.10	21	86.01	CHANGED	hh..hhs....slhshhhhhlshhssthRhttth.......................s.....................ts....hhpR.....................................stRAatNthEthshFhshhhlhtl.t......................shhsshhuhhalsuRllas.hsa...hts......hsh..hRs.hs....ahluhlshhslhlhslh	.........................................................................................................................h.hhhsslhslhh.hhhsh.ls.p.h.R.h.p.hp..s..h.......st.............s.................................hs.....thpp...............................shR..sa.tNsh.EhhPlal..s.h.h.lh.hth..s......ss..............s.......shhsth..hu.......hlalsuRlhah.hua..........hts.......hhh.......hRt..hs....hh..hshhshlhhhlhsh.h.............................................................................	0	315	546	790
+3283	PF01914	MarC	UPF0056; 	MarC family integral membrane protein	Enright A, Ouzounis C, Bateman A, Dlakic M	anon	Enright A	Family	Integral membrane protein family that includes the antibiotic resistance protein MarC.  These proteins may be transporters.	23.60	23.60	23.70	23.80	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.15	0.71	-5.20	12	4024	2012-10-03 02:02:08	2003-04-07 12:59:11	12	4	2220	0	892	2286	718	199.30	30	95.29	CHANGED	hphhhtshlsLhhlhsPlGslPlFloLhpphstcc+pplhh+sslhuhllLhlFhhhGchIhp.hFGIslsuh+lAGGIlLFhIuhcMlpup.pt.....ptpppEtpt...h-plullPLAhPLlAGPGuIToshlhhsptss.........hhhshlulhLshhhshlhhh.ushlhRhlGctGlsslsRlhGllLsslulQhllsGlpshh	............................hhpshlsLhslhsPlG..slPl.Fluls.p.ths.s....tpR....p....c......h.....s.....hp.....uslhsh..lll.h.l.hhahGphlLp.hFGIolsuh+I.AGGlllhhIA.h.c..Ml.h.s.ptst.................t..p.s..p..p.....p....t......t..................t......................t....ps..l....ulVPLAhP..lhAGPGs.I.uslllh...u.s.p.h.t.s..........h...t..h..h.s..h....h.....l.u.lh.l.s.h.l....hs.a.h...l...h.t.h.us.hlhRl....L..Gp...s....G.......l....sllsRlMGllLsslulphllsGlpth......................	0	241	508	711
+3284	PF02063	MARCKS		MARCKS family	Mian N, Bateman A	anon	IPR002101	Family	\N	19.50	19.50	21.30	20.30	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.43	0.70	-4.56	4	119	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	35	1	60	106	0	175.90	36	96.19	CHANGED	GAQFSKTAAKGEAA.AE+PGE.AVAuSPSKANGQENGHVKVNGDASPAAAEuG.KEElQANGSAPA...EEsuKEEAAou...............tAAsccEAuAu...........sAEuEsAEPuSP...AEGEuA.....opTp..cAtssATPSsSsETPKKKKKRFSFKKSFKLSGFSFKKNKKEuGEGAEuE.GAsAt..tEtAK--AAAAAsEAsst..EpAtAsuEEAuAAus.pttttcEs..AusupPp..EsKs-EA..APEK.PsuEEspsAEE...pKsEEKsAEEAs...AsuAA...sEAPuu.......EpEAAsAEEP.........AAs..sQEAsSEsSPt..AssAE	............................ss+t-ss.s-...t..s..ss..sKsNGQ....ENGH.s+.NGshost.........................................................................spu-.sh-sss..........................u...ts.s...sspETPKKKK.+FSFKK.sFKLSGhSFK+s+KEsutsupst..uss.t...t-ttttt.t......ts.t......t....-ttt.ss..ps....t...........t.t...tttst..t..E..t..stts...t..pt...st...t.....................................................................................................................................	0	3	11	27
+3285	PF02124	Marek_A		Marek's disease glycoprotein A	Mian N, Bateman A	anon	IPR001654	Family	\N	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.45	0.70	-4.86	15	236	2012-10-03 02:52:13	2003-04-07 12:59:11	10	1	52	0	0	276	0	201.10	41	44.49	CHANGED	YYPspSsclpWFpsGp.sVc.spalcsshphts-.G.lhopsSslol.........ssssstsh.PPolRCp......lsWa+cuVuppRh.......suussPsVYhtPplol.cFtsGcAVCsApCVPcs..VplpWhlsDt....sssssshtsGsCsp+PGLVNlRSshslSttcushcYTCpLsGYPpslPsFpcotsaDASPpssutshllsll...uVlsGlsslullsllsslClhp	........................................................YYP..psVchpWFpcst.tVt.ssplcsthptpss...G..FopVSsVT..........t..ssssps..PsslpCp......hsWaRD..uVs.pRh.......sAsuhPtVhs.hPslol.....tF....t.s.uasVCTAtCVPcG..VshsWhlsDss....sAspsshpsG.Csc+PGLsslRSshPl..S..t.....t..u...-YoC..+L..s..GYPsslPs..h......ptptoa..p.s..s..Ptsso...V.hphl...ulhhhlhshGllslhshlhlh.......................................................	0	0	0	0
+3286	PF01047	MarR		MarR family	Finn RD, Bateman A	anon	Pfam-B_269 (release 3.0)	Family	The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR.  A large number of compounds induce transcription of the mar operon.  This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.37	0.72	-4.26	38	19890	2012-10-04 14:01:12	2003-04-07 12:59:11	17	44	3773	111	4329	25839	3062	58.30	23	35.57	CHANGED	lohspatlLthltppss.hshs....cLApphplspuslTphlc+LEcpGhlpRppsspD+Rpl	.................................lo.sph.h.l...L...h....h....l......t.....p.....p.........s........s.....h.....s.hp............cL....uc.tl..t.....l....sp........u.o.lo..p...hlccL..Ec..c..G..hl..pR.p.p..s.....p..D+Rt..........................	0	1317	2694	3560
+3287	PF02064	MAS20		MAS20 protein import receptor	Mian N, Bateman A	anon	IPR002056	Family	\N	23.40	23.40	23.60	30.10	23.10	22.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.45	0.71	-4.20	33	336	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	234	22	220	310	0	124.60	35	71.87	CHANGED	lsAGl.u..ushFlGYClYFD+KRRSDP-aK+KL+ERR...+cptpp..........ttsssstl.P-h.pD....pcslpcaFLp..ElphGEpLlspGch-pGlcHLs.NAlhVCuQPs....pLLplLQpoLPsplFphLlp+Ltt	....................................................sus.s.ush.hlGYs.lYFDhKRRsDPpF++.pL..+..c..+R....+ppttt...................................t.ttthttlssh...p-..................s-thppaFhpplphGE............pL...hu...p...G..c........h.....p..........c....ust.+.hhpAl.tVhsQPp....pLLplhppTlP.sVaphLlp.h..h.........................	0	56	93	163
+3288	PF04769	MAT_Alpha1		Mating-type protein MAT alpha 1	Kerrison ND	anon	DOMO:DM04990;	Family	This family includes Saccharomyces cerevisiae mating type protein alpha 1 (Swiss:P01365).  Mat alpha 1 is a transcription activator which activates mating-type alpha-specific genes.\	    MAT alpha 1 and MCM 1 bind cooperatively to PQ elements upstream of alpha-specific genes [1].\	Alpha 1 interacts in vivo with STE12, linking expression of alpha-specific genes to the alpha-pheromone (Pfam:PF04648) response pathway [1].	22.10	22.10	22.10	22.80	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.22	0.71	-4.99	13	507	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	358	0	51	428	0	156.70	31	59.93	CHANGED	chlss.....hhpshtphccsAuhtAhouphhhss.......hst.ssssppAKKslNuFhuFRoYYh..shFsphPQKchSshlolLWptDPp+shWslMspsaSsIRDpluK......ppssLspFlshtsPhhtl.s.stYhplhGWsLopsppGshslp+sssschpphspshs.shsLshpslhshlp.hhhsssashhsphsssoaphhphss	............................................................................................tth..t.t.s.p.t.s.+.+.sLNuFhuFRsY................Yh..hhFs.s.hp.QKphSshlshLWps.D.Ph.+.scWulhAKsYShlRDphsc......tpssLstFhslhsP..hhsh..st.Ylt.hGWt.....h....t.s.pu...................h.p..h....t...............h...slht.h....h..........................................................................................	0	8	25	44
+3289	PF01554	MatE	UPF0013; 	MatE	Bateman A	anon	Pfam-B_163 (release 4.0)	Family	The MatE domain	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.61	0.71	-4.62	58	32381	2012-10-02 21:24:20	2003-04-07 12:59:11	13	52	4365	8	7913	28954	6802	160.40	16	68.74	CHANGED	Phhls.hlps..........hhthlsshhlupl..GstslAuhuluhslhshhhh.........hshGlusuhsslsupthGApphcphthshtpuhhlshhlulhhsllhhhhsp.lhphhssstp......lhphutpalhhhhhshshh.sh.hshsuhLputGcschshhlshhuh.llslslsal	...................................................................Phhlt.hh...........................hh.th.l.s......s..h.h....l....u.........p......h.......G...........s.......t..s............l........A.....u......h.....u....l..........s.....h..s..l.h.t.h.h.hh.........................hh.h.u.l.u.....hu..s.....s........s........l.........l....u......p.........t..........h.......G...........u........p........c............h............c............p........s................p......p......h........h....t...t....u....h..............h....h.u..hh.h.u.l.l.h.....sl.l...h....h...h..h.s.....p.....l....l..t....l....h.....s....s.....s..s.p............................l.h.p......h..u......t...p.a....l..h.....l.h....h....h......s....h............h....h.h.....s....h....t...h......s.....h.....s.............u.................h...hp...u.h....u...p....s...p......h...s...hh.hsh...h...s..h.....llsl.shs..........................................................	0	2610	5153	6676
+3290	PF01824	MatK_N		MatK/TrnK amino terminal region	Bateman A	anon	Pfam-B_30 (release 4.2)	Family	The function of this region is unknown.	21.70	21.70	21.70	21.70	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.12	0.70	-5.34	15	38881	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	26823	0	17	37918	0	249.20	57	67.98	CHANGED	MEEappYLELD+SQQHsFLYPLIFQEYIYALAHD+GLNR.....SILLENsGYDN.K.ShLIVKRLIT....RMYQQNHhllSsNDSNQNhFh....GaNKNhYS..Q..MISEGFAlIVEIPFSLRLlSSL...Et.KclVKSaN..LRSIHSIFPFLEDpFuHLNYVLDILIPaPIHLEILVQTLRYWVKDASSLHLLRFFLaEYpNWNoLIT..sKKu.asF.SKRNpR..hFLFLYNSaVCEYESIFlFLRNQSSHLRSsSSGshLERIaFYGKIE+hl.EVFs+DFpssLWLFKDPFhHYVRYQGKSILASKGTsLLMNKWKYYLVNFWQCaFYlWsQPGRIaINQLSNHSLDFLG	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.......p....l.....clhIPaP.lH.hEIL..VQhLp..hWl.pDssSL..HLL.....R.....F.F.L..a...E..........Y...p.....N.........a......N......S......L...I...T................sK....K.........u.........h.................h..........F.....S........K....c.............N....p..R.........h.F........h....F....L....Y....N.....S.aV.h.EY..ESl.F.l.F.L.R.p...Q.S.S..a.L...R...S.TS...G....s..h.L..ER.la..FY..s.....K.....I.........E.......+.......l............l................V.....a........s......p........s........F........p.......t....h...L......W..h.......F.....K..D..P..F......h...H.YV...R...Y..Q.GK.u.ILA..S..K..G.......T..........L...L...M..p.K..WKaYLVNhWQ.ha..Fhh..W..s.Q..P.....t...R..I..a..I...N..Q..L...S..p..a...S...hpFLG............................................................................	0	2	8	14
+3291	PF00661	Matrix		Viral matrix protein	Bateman A	anon	Pfam-B_128 (release 2.1)	Family	Found in Morbillivirus and paramyxovirus, pneumovirus.	19.80	19.80	25.80	23.60	17.30	15.60	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-11.86	0.70	-6.13	13	784	2009-01-15 18:05:59	2003-04-07 12:59:11	16	3	105	0	0	688	0	266.80	48	96.27	CHANGED	pshhshspsuhsssusLpPhPlphss....cG+Ll.QlRltclspssc+cpshsal.sYGFlcsscppsshlGt.p...ps.ttthhTuuhLPLGsG.shusspclLcthsphcIpVR+TAuspEplVFplsshsplLpsaphshpphhlhsAsKhs+uPsplssshshpaplsFlSlThhsssttaplP+slLchRSppshulpLpVhl+lpscs-SshhKshhsccptcs..AohhlHlsNlp+pcsc..hYss-YhppKlcpMpLshuLuslhGsoltl+usG+lsKThtshhuh+thsCaPLhDlsPsLs+hLWusuCEIsclpAILQsSs.p-hhhasDlIhcclphhhc	..............o..hhth..ss...pspl.sh....h..h.t......ctplh.QhRl.c.s.hscpc-s.hahhhhGhl.p.ss...tsslG...............hs.u.LsLGss.ssuc..-Lh+tshphslss++oAs.sEchVF..sps.plLpshhhshsphs.hsAsphspAsphlPhsss.ca+VsahSlThlscpshYplPp.thLchpusshhslsLpVTlcl-scscSshlKolsc...u-sshh....AslalHIG.hspscp+h+phohDhhcpKIR+hsLsVuLuDVhGsSlhl+upGthoKhLts.hu.ptshCYPlhshs.pls+lLWpppsplhplpsllQsus.pthtlhsDh.lsssph.h.t.............	0	0	0	0
+3292	PF03819	MazG		MazG nucleotide pyrophosphohydrolase domain	TIGRFAMs, Griffiths-Jones SR, Bateman A	anon	TIGRFAMs	Domain	This domain is about 100 amino acid residues in length. It is found in the MazG protein from E. coli. It contains four conserved negatively charged residues that probably form an active site or metal binding site. This domain is found in isolation in some proteins as well as associated with Pfam:PF00590. This domain is clearly related to Pfam:PF01503 another pyrophosphohydrolase involved in histidine biosynthesis. This family may be structurally related to the NUDIX domain Pfam:PF00293 (Bateman A pers. obs.).	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.32	0.72	-4.03	54	7328	2012-10-01 21:36:44	2003-04-07 12:59:11	12	20	3581	41	1765	5952	4148	73.70	28	47.30	CHANGED	Qohpolh.allEEshEls-AI.cc..........p-.s...........plc-ELGDlLhpVlhhuplupc..pstFslp-VhpplscKhhcR+P+lF	..........................................................shh.hlhEEstE.l.h.-...s..l....pp.........................................p.-.tp..................................cl.p.-ELG....DlLhtl..l.hhAph...............hthc.hccs..hpph...scKh.cRh..............................	1	620	1185	1510
+3293	PF04837	MbeB_N		MbeB-like, N-term conserved region	Mifsud W	anon	Pfam-B_3854 (release 7.6)	Family	This family represents an N-terminal conserved region of MbeB/MobB proteins. These proteins are essential for specific plasmid transfer.	21.30	21.30	21.70	21.70	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.31	0.72	-3.87	9	115	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	74	0	3	93	2	51.20	41	30.92	CHANGED	MSplLsLApsFEp+SKppupSTpchlpssFccHEpslpptLppupp+Is-AI	.....MSplLsLAp-F...EpKSKpctpSTpphLpssFpchEpulpptLppupp+IpsAI.....	0	1	1	1
+3294	PF04899	MbeD_MobD		MbeD/MobD like 	Finn RD	anon	Pfam-B_5673 (release 7.6)	Family	The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilisation and transfer in the presence of conjugative plasmids [1].	21.40	21.40	21.40	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.37	0.72	-4.07	6	132	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	105	0	14	86	0	74.90	43	78.49	CHANGED	MTELEppLLSALEQLQQDYpQRLpEWESAFs-hQ+MhuLppRENA.......ALSEpVTsLSQQVpcLScQlcRLSp	............................MpELEhpLLsAhppLQpsappphppWpSuaspLQphhphoppcpu.......sLpt+sptLspplppLstphp...................................................	0	5	8	10
+3295	PF03621	MbtH		MbtH-like protein	Yeats C, Eberhardt R	anon	Yeats C	Domain	This domain is found in the MbtH protein Swiss:O05821 as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologues were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al [1]. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues [2].  The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape [3]. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids [3-6].	20.80	20.80	21.10	21.10	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.81	0.72	-4.60	87	1247	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	966	4	274	742	10	53.60	46	64.74	CHANGED	M....sssF-csss....pahVLlNcEtQaSLWPshtslPsGWpssh...G.su.......sRpsCLcal-p	...............M..oNPFDcspG.....sFhVLhNs-tQaSLWPsh..sslPAGWclVht.st.......o+tuClpalE........	0	50	144	224
+3296	PF02289	MCH		Cyclohydrolase (MCH)	Mian N, Bateman A	anon	Pfam-B_6511 (release 5.2)	Domain	Methenyl tetrahydromethanopterin cyclohydrolase EC:3.5.4.27 is involved in methanogenesis in bacteria and archaea, producing methane from  carbon monoxide or carbon dioxide.	25.00	25.00	102.30	102.20	23.50	22.50	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.00	0.70	-5.39	6	211	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	188	1	101	219	69	285.00	43	96.87	CHANGED	SVNchAtplVEcMl-tuE-L+l-VtKLENGATVlDCGVNssGSa-AGhhaoclCLGGLAcV..slsshphsulshPsVplpTDaPAIAsLGuQKAGWplp..VGc..YFAMGSGPARALALKPKETYEEIGYEDDADlAVLsLEuscLPsEcVsEalAcECuV-PENVYlLVAPTASlVGSlQISuRVVEsGlaKhhEVh.FDls+lK.usGhAPIAPlhsDDlpAMGpTNDsllYGGpsahaVcuD-..s-lcplscplPSssScDYGKPFh-lFKcAsYDFYKIDsGhFAPAcllVNDLpTGKoapuGclNsElLhpSFG	.........................SlNthuh.ll.cphlp.u....ccLpltltphpsGspllDsGlp.s.GuhcAGhhhsclChGGLupV...sht....t..th...t.sh.h.shlpVpospPslACLuSQhAGWpls....htc.....aFAlGSGPARALAtc.........c........cla.c-l.s..Yc...D.pu-.t..u....lL.sLEusplPsppVs-clAcpCGV.sPpslhlllAPTsSlAGoVQlsuRVlEsAlHKhppLt.F-lpcIlsuhGsAPluPst..sDtlpAMGRTNDAllYGGpshhhVc..ssp..tthpplspplPSss.Sc-YG+PFh-lFcphshDFYclDstl.FuPApVhlsslpoGcsapsGpls.plLtpSF.............	0	27	71	90
+3297	PF00493	MCM		MCM2/3/5 family	Bateman A, Finn RD	anon	Prosite	Family	\N	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-12.00	0.70	-5.64	62	3858	2012-10-05 12:31:08	2003-04-07 12:59:11	18	63	938	2	2067	6744	833	253.70	39	40.85	CHANGED	-hcplpcl.uccs..slhpplspSlAPsIaG..p--.lK+AlhLtLhGGsp.K..phsc.thc..lRGDINlLllGDPG.sAKSQlLKal.p.pluPRuVYToG+GSSAsGL.TAuVh+Dstot-...asLEuGALVLADpGlCCIDEFDKMs-pDRsulHEAMEQQTISIuKAG.Ihso.LNARsSlLAAANPh..hGRYstp+ohspNlslssslLSRFDLl.FllhD.ps-cppDpplAc+llshHhtt...........................ppphptp.................................lshchL++YItYA.R.phpP..t....Loppu.pctlsphYlphRp.s........tt...ttthslTsRQLESlIRLoEAhA+h+LuphVstcDVccAl+LhppShh	.........................................................................................................pplpph..t..p.p.....plach..lspSlAPp.Ia..........G..........p..............pc...l.......K+Al.lLhL.......h.G........Gs.........p.............K...................p..h.....s.....s...........s..h..+.................lR...GD......I.....Nlh.lhG...DPusuK....S...Q.h..........L.p....a....h..............p....h....s.......s...........h..........u........l..........h...........o....o...........G.....p............u...u..........S.......u...s............G.......L........T......A............t..........l.....h.....+........D.........................o..t..p......................hh....l.......E..u.......G.A........h.......V............L.u..D.t....G.....l.............sh....IDEF.D.K..Mp.t.....s...psslHE.......sMEQ..Q..o.l.......ol........u.....K....AG......l..h.sp..L..p..uR.s.ul...lA..Au...N.Ph..............u.................p....a..................s................................h.........s................................t.........N.........l............t............h.........sl..lS.R....F..D..l..............h.........h........l........l.........h........D.............s...............................D....................l....up.....a..l.ht..a..t...................................................................................................................................................................................h.s...t..............h....p...p..Y....l.......h.s...+..................t....h..t............P.......h.....................l..s.........s....t..p......h.l......p....Y....t.hRp.t..................................t.......tt......h..os.RpLts....hlRlup....uhA+hphp...t................s.t.t.cst..Ahplh.....h...........................................................................................................................................................	0	763	1189	1734
+3298	PF00015	MCPsignal		Methyl-accepting chemotaxis protein (MCP) signalling domain	Sonnhammer ELL	anon	Blast MCP1_ECOLI/361-421	Family	This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.51	0.70	-4.79	9	30898	2011-09-19 18:58:56	2003-04-07 12:59:11	16	309	2287	12	9245	27179	1335	198.30	30	36.30	CHANGED	ppAo-hAppAsppA..............ppsspsVcpslpshcplsspSppIscIlsVIspIA.QTNlLALNAAlEAARAG..EpGRGFAVVAsEVRsLAp+SApAA+EIcsLIppsspp..............l-sGsshlcpTucshpcIVsulsclsshls-IAuuosEQSpulppls....pulschsplTpps..............sAhsEEuuAAutsLcppApcLpphlstF+lp	.......................................................................ttt.........................s..............................h...p...p....h....s...p.......t....h.......p....p.......s.......s....p.......s...h.......p....p.......l....s...p....p....u.......p.......p.......I.s...........p...l...l.......s.l.......I...ps.......I...A...p...QTNL......LALNA.A.I....E.A.....A..R...A....G............Ep....G......R..G.........F.AVVAsE.......V.......RpLAp+.....o.......t.......p.......u.......s.......p.......E.......I.......p...........p.......h..........I....p.......p.......h..............p.......p.......p.............................t.....................................................................................h...............t...........................................................................s........p..........p........u.......s...............p........h..................s..............p.......p.......s.......s...........p.............s..............h..............p..................p..............I..............s..................p..............s.......l..............p....p..............l.......s.......s...........h..............h..............p..............p..............I.......u..............s..............u...........s..............p.......c......Q.......s.......p........s.......h....p....p.....ls................ps...l....s.......p....l...s....p....h...s.pp.s..........................................ss.h....spp.s...s.......t....s.......u.......p.......p.......L.......p.p.....u.......ppL.pphlt.Fp..................................................................................................................	0	2775	5451	7351
+3299	PF02993	MCPVI		Minor capsid protein VI	Griffiths-Jones SR	anon	Pfam-B_1634 (release 6.4)	Family	This minor capsid protein may act as a link between the external capsid and the internal DNA-protein core.\	    The C-terminal 11 residues may function as a protease cofactor leading to enzyme activation [1].	25.00	25.00	27.70	27.70	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.55	0.70	-4.21	9	139	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	101	1	0	157	0	227.40	52	97.63	CHANGED	FusLAPRpGspPhhu..psIGsS-h+GGtFsWGSLhS....Gl+shGSslpNhup+hhNSpThp.l+ptlpDoslhcpVsphhupulsulVDIuR.clppclpphh-+h.s.....-p.hsptcsh..s...h.tstpstscP.scpshlstsstP.Psh.psl..hs......hsspcPhhs.shssss...psPsplshPP..tsp....ssss...s.....ssppsp..............+.hRsusWQusLssllGhGVpsspRRpCY	...........FuSLAPRHGoRPaMGTWs-IGTSQLNGGAFNWuSlWS....GLKNFGSTl+oYGsKAWNSSTGQhLR-KLKDQNFQQKVVDGlASGINGVVDlANQAVQ+pIsSRLD..P..hPs..................pt.h...-th.................s+G-KRPRP....DtEEsh.lhpscEP.PSYEEAlK.G............hPsTRP.IAshAs.uVh.......pPsTLDLPP....sPs....sssss........ss.s.s.....s....ss.ssstR..................ssttpt.stNWQSTLsSIVGLGVpSlKRRRCY.................	0	0	0	0
+3300	PF02249	MCR_alpha		Methyl-coenzyme M reductase alpha subunit, C-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2706 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain is comprised of an all-alpha multi-helical bundle.	25.00	25.00	32.70	26.70	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.78	0.71	-4.12	22	7244	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	318	31	49	7541	13	118.60	61	67.10	CHANGED	DQIWLGSYMSGGVGFTQYATAAYTDNILDDasYY....GhDYlp-KYG...s........scu.s.oh-sVpDlATEVTLYuLEQYEcYPThLEDHFGGSQRAsVhAAAuGsosAhATGNupAGLuuWYLS.hLHKEuaGRL	....................................GVGF.TQYATAAY..TDNI.LDDas.YY....GhD.YlcDKYG.......s........h.s..+sKs..ThDlVpDl.ATEVTlYGhE...QYEpaPThLEsHFGG....SQRAuVlAAAuG.hosulATGNuNAGL..suWYLS.MhLHKEuauRL..............................................................................	0	10	32	41
+3301	PF02745	MCR_alpha_N		Methyl-coenzyme M reductase alpha subunit, N-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2706 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (this family), 2 beta (Pfam:PF02241), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has a ferredoxin-like fold.	20.50	20.50	21.00	20.50	19.40	20.00	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.81	0.70	-5.19	5	1424	2009-09-10 16:32:42	2003-04-07 12:59:11	10	3	189	31	50	1557	13	56.70	70	20.77	CHANGED	EKKLFl-AL+cKFc.E-PcEKpTKFYsFGGWKQSERK+EFVEaAKKlAEKRG.IPFYNPDI..GVPLGQRKLMPYpVSGTDsaVEGDDLHFVNNAAMQQMWDDIRRTVIVGMDTAHcVLEKRLGKEVTPETINEYMETlNHALPGGAVVQEHMVElHPGLVsDCYAKIFTGDDELADEIDK+FLIDINKpFPEEQAEQLKKAIG+RTYQVsRlPTIVuRsCDGATsSRWSAMQIGMSFISAYKlCAGEAAlADFSFAAKHA-VIpMGohLP	.....................................................................................................................................................................................................................................................................AMQIGMSFIuAY+MCA.GEAAVADLAaAAKHAuVlpMushLP............	1	11	33	42
+3302	PF02241	MCR_beta		Methyl-coenzyme M reductase beta subunit, C-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2692 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The C-terminal domain of MCR beta has an all-alpha fold with buried central helix.	25.00	25.00	325.40	325.00	24.30	18.90	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.52	0.70	-5.17	6	82	2009-11-23 11:17:05	2003-04-07 12:59:11	13	1	65	31	49	86	12	252.00	65	57.60	CHANGED	GYALRNIMsNHlVAsT+KNThNAlALuoILEQTAMFEMGDAVGuFERhHLLGLAYQGLNADNLVaDLVKtNGKcGTVGTVVASlVERALEDGVI+VcKpLsSGFKlYcPsDhAhWNAYAAAGLVAAshVNsGAARAAQGVASTlLYYNDILEYETGLPGVDFGRAEGTAVGFSFFSHSIYGGGGPGIFpGNHlVTRHSKGFAIPsVAAAMCLDAGTQMFSPE+TSuLlGoVaStIDEFREPLKYVsEGAsElKc+	GYuLRNIhsNHhVAhT+KNshpAsALoSIhEQsAhFEMGsAlGsFERhHLLGLAYQGLNANNlVaDLVKpNGcsGTVGoVVtSlVERAlEDGVIpscKphsSG.aphYcssDsshWNAYAAAGhlAAshVNCGAuRAAQuVuSTlLYaNDlLEaETGLPGlDaGRspGTAVGFSFFSHSIYGGGGPGlFNGNHVVTRHSKGFAIPCVsAAMsLDAGTQMFSPEpTSuLlGsVautI-EFREPlKhVAcuA.........	0	10	32	41
+3303	PF02783	MCR_beta_N		Methyl-coenzyme M reductase beta subunit, N-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_2692 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (this family), and 2 gamma (Pfam:PF02240) subunits with two identical nickel porphinoid active sites [1]. The N-terminal domain has an alpha/beta ferredoxin-like fold.	20.90	20.90	23.90	32.00	20.00	17.60	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.92	0.71	-4.83	7	83	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	66	31	49	89	12	178.50	51	41.17	CHANGED	DplDLYD-+GpLlEEsVPLEAlSPL+NPsIpslVpDlKRoVAVNLAGIEsALpsuplGGKushI.GREl-LsIVtNAEuIA-plK+hlQVsEDDDTsVcLlssGKphLlQlPSpRlcVAA-YosusLlsutAlspAIIctF-VDMaDAshVKuAVhGpYPQolDahGuNlAolLusP.pLEG	...D+IDLYDD+GpLLcpsVPLEAISPLpNsuIp+llpssKRTVAVNLAGIEsuL+TGplGGKuppI.GRELDlsIVsNA-uIA-clcchlpVp-sDDTsVcllsGGKphLVQlPotRlcsAA-YoluhhssAuAlspAII-pFclsMaDAshV+AAVhGpYPQohDhtGGNluolLslPpp.EG.........	0	10	32	41
+3304	PF02505	MCR_D		Methyl-coenzyme M reductase operon protein D	Mian N, Bateman A	anon	Pfam-B_2115 (release 5.4)	Family	Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha  (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240) [1]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D [2]. The function of proteins C and D (this  family) is unknown.	25.00	25.00	108.30	108.10	18.90	17.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.76	0.71	-4.65	10	75	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	59	0	51	72	4	148.00	41	92.72	CHANGED	I-VcIFPHRlLpA-TTEKlLNclY-.l-GltRVllHGpsLPcpVsaGPA+GhPVNHs-R+lIpVKGp-lEL+VpVGRIhVplcD.c..-ppl-cI-EICcElhPFuYclpsG+Fh+ccPTVTDYlKYGcc....lcclDsRLlGhVDPpuRhpssVslIK	..h-lEIFPpRhLps-TTEKlLNclhs.l.cGlpRlllaG.sLPcpVsYGPA+GtPlsHs-R+hIpVpGpslELpVpVGRlhlpl-s.....-shl-cIcclCc-.hh...P...FuYclp.....GpFh+scsTVoDYhKYG.p.....sphDccllGhsDP+u+hppplthl..........	0	11	32	42
+3305	PF02240	MCR_gamma		Methyl-coenzyme M reductase gamma subunit	Mian N, Bateman A	anon	Pfam-B_2713 (release 5.2)	Domain	Methyl-coenzyme M reductase (MCR) is the enzyme responsible for  microbial formation of methane. It is a hexamer composed of 2 alpha (Pfam:PF02249), 2 beta (Pfam:PF02241), and 2 gamma (this family)  subunits with two identical nickel porphinoid active sites [1].	25.00	25.00	320.70	320.50	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.56	0.70	-5.24	7	85	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	67	31	49	88	13	246.80	61	94.67	CHANGED	sQaY.PGpTplApNRRKaMNP-hELcKLREIsDEDlV+lLGHRsPGE-Y.SVHPPLEEMD.PEDslR-hVEPhpGAKtGcRVRYIQFsDSMY.APAQPY.RuRsYhWRaRGlDsGTLSGRQlIEhREpDLEpluK..LlETEhFDPApsGlRGATVHGHSLRLDENGlMFDhLpRhlasE-TG+VhhVKDQVGc.LDEPVDlGcPLsE-pLtchTTIYRlDslshR-DcEhlElVpRIHphRThuGFtP	...PQaYPGsTpVApNRRKaMNPshcLEKLR-IsDEDlV+lLGHRuPGE-YpolHPPL-EM-EP-sslR-lVEPhsGAKAGDRlRYIQFsDSMY.APuQPY.RuhshhhRaRGlDsGTLSGRQlIEsRERDLEcloK..Ll-TEhFDPApsGlRGATVHGHSLRLDEsGhMFDhLpRhlhsccoGpVhYVKDQVGpPLDc.VslGcPlsE-cL+c+TTIYR.hDsluh........R-DtEsl-lVp+IHptRThuGFt....	0	10	32	41
+3306	PF02315	MDH		Methanol dehydrogenase beta subunit	Mian N, Bateman A	anon	Pfam-B_12628 (release 5.2)	Domain	Methanol dehydrogenase (MDH) is a bacterial periplasmic quinoprotein that oxidises methanol to formaldehyde. MDH is a tetramer of two alpha and two beta subunits. This family contains the small beta subunit.	20.60	20.60	21.10	20.70	19.70	16.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.06	0.72	-4.05	4	44	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	44	23	21	47	0	90.00	58	93.97	CHANGED	MKplLshhslAushu..hsssALAYDGTpCKAPGNCWEPKPGaPEKIAGSKYDPKHDPtELsKQsESlKsM-ARNtpRltNhKKTGKF.YDVKKI	..............hhhhshhsushs...hussAhAYDGTpCKAPGsCWEPKPGa...P-KlAGSKYDPKHDPpELsKQs.pSIcuMEpRNtKRltpFKKTG+FhYDVpc........	0	6	16	18
+3308	PF04349	MdoG		Periplasmic glucan biosynthesis protein, MdoG	Mifsud W	anon	COG3131	Family	This family represents MdoG, a protein that is necessary for the synthesis of periplasmic glucans. The function of MdoG remains unknown. It has been suggested that it may catalyse the addition of branches to a linear glucan backbone.	25.00	25.00	28.80	28.60	17.70	17.30	hmmbuild  -o /dev/null HMM SEED	484	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.60	0.70	-6.23	4	1625	2012-10-02 23:57:29	2003-04-07 12:59:11	7	2	926	2	268	967	64	475.30	48	91.60	CHANGED	FshDsVscpA+sLAucsYpu.KssLPoshpchpas-YQpIRFppD+AhWss.csPFplpFaHpGhaFcoPV+IsEVsustspclpYDPshFsaG.slhpscpssKDLGaAGFRVhYPlNotccpD.ElssFLGASYFRslGpGpsYGLSARGLAIcTA.PuGEEFPcF+tFWlE+PpssscplVlYALLDSPpsoGAYRFslpPGcsslMDVputla.R-cluKLGlAPhTSMahaGsNp.p.spsaRPElHDSsGL.lhsGNGEWlWRPLsNPpaLpVSsF.spNPpGFGLLQRsRDFu+YpDL-s+Y-hRPShWVEPKGsWGcGoVpLVEIPT.DETpDNIVAFWsPcp.PcsGpEhpFuY+LpWu.spsclp.PpsuaVppTtpuhGDVtppshhR...hohtFVVDFpGsthKtLssstPVospsslcsNutllEs.olR.NPsh+GaRLshclcst-s.pp.sEhRAtLsspsscPLoETW.YQhs...h	..................................Fshs.ltphApsLAtpsap..u.s..p.s.LPs.s.lt..shsassY.ppIQass-+uhWps....l.c.p...aclpFaH..G.MhFcp.V+l.pV..s........s.......s....t....s+c.......I+.......asP-hFsa.s.......-s...t..h....D..p...-..s...s...p.....D..L...G...FAGFRVh..h.....s.......h...s..p........p.......t..pc....-lVSFLGASYFRslGsst.YGLSARGLAIDT.uh.s.o.s..EEFPcFptFWlEpP......K....P.s.s.pplTlYALLDSPssTGAY+Fs...I..p..s..G.+.s....s.l.h.DVpu+lYhR............cc............lpcLGlAPhTSMFhaGsN......p.......p................ss...saRPplHDS-GLuha.s.G....N....G.........E.........WIWRPLNNP....p.+.L.p.houa.ssc.N.P+GFGLLQRsRDFS+YpDltshY-pRPShWVE.P...........+....u.........c...........W.GKGsVpLlEIPTssET.DNIVAaWpP-p.hs..csG.......cEhsFpY+LhWS...s...............p.s.......l+..ss.h....AhVht.....T......RpuhG...s.h...........p......ss........hh.....chshtFsVDFsGu.-h.K..........h.sts.s.......P.h.....sh.pss.I.s.s.s.u..thl...........cp............p.lt..Y....s..s..s..h..c..G.aRlhhchh.......s.p..........ss....pc..........ss-MRhhLts...t.s....ps..lSETW.YQh..h...................................................................	0	60	133	191
+3309	PF02975	Me-amine-dh_L	Me-amine-deh_L; 	Methylamine dehydrogenase, L chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	25.50	25.40	17.80	16.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-11.05	0.71	-4.14	2	110	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	90	102	36	118	21	113.60	54	68.56	CHANGED	.sRttapPQDpD.puCDYWRHCSIDGNlCDCsGGSLTsCPPGTcLusuSWVASCaNPsDGQoYLIAYRDCCGhpssGRCsClNspGELPVYRPEFsNDIlWCFGA-sDAMTYHCTlSPIVGKA	.........ts..........t.t.Ds.puCDYWRYCAIDG.LCo.CCGGohoSCPPGTpsSPsoWlGoChNPtDGpsYlIuYpDCCGKso.C.G...cChC.ps.Et.EpPlY+P...phsNDIsWChGsts....YpCosusllGh.....	0	7	19	26
+3310	PF04934	Med6	MED6; 	MED6 mediator sub complex component	Wood V, Bateman A	anon	Pfam-B_4045 (release 7.6)	Family	Component of RNA polymerase II holoenzyme and mediator sub complex.	20.20	20.20	20.20	20.60	19.30	20.10	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.89	0.71	-4.63	32	317	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	279	3	225	313	2	139.90	37	51.89	CHANGED	lpW+sPpalp....................h..sLp....ssNVL-.YFup..SPFYD+oSN...Npll+hQtphsp.................................................hppcLppMsGlEa.llsps..pEP...................................slaVI+KQpRps.............sspspslssYYlluuslYpAPslhsllsoRl....................hsslhplppu....hsphs.phspasP	................lpWpsstal.............................hLp.....ssslL-.YFup...sPFYD+TsN...Npsl+hQphh.p.......................................................................................cLppM.s..GlEY...llhps..pEP....................................lalIRKQp.Rps.................ssplhsLusYYIluu..s..lYQAPsltsVls..SRl........................loslpslppuhcpst.shspapP.........................................	0	76	120	183
+3311	PF03525	Meiotic_rec114		Meiotic recombination protein rec114	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	33.70	30.80	24.30	19.70	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.03	0.70	-5.94	4	26	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	25	0	15	25	0	261.40	35	69.83	CHANGED	YS+YTIPSaAPsGFsShLEPPpIDKWQHLSsNCTLQF+VLLhDStQlhlpVlLNNSThLEpIRLPLGsNpDhIQFSCKsPIISCKYISEEFGP+hL+RFQlNLPNDl-FNRslVSLKNLsFVl+TAKTSIApsThssQsps.NNupKlsFsEss.NsSoYppsNsQFQ............................TQNMlhDFSQphQEKstREssNpSNITLPpDs..hsIsQQpaPss-hNVVpoSQDLNTPpATQTlhupPEsL.VpshElSpshssooss.PshcNppppsthsSDhhS+Kthh.pp.sshhpshcLPKERpppEpplpuhh..hpsssThlhS.tppNpl+pNs	..................YSpYs....APpGFpohhpPs.pl-KWpH..l..S.ssssL.pFplLLh....cspp.lhlpV..lhN.........N.uslLEpIplP.l.....us.s.......p-lIQFSsKuPhISCKYlscch.usp...h.lRRFQhsLss-s-Fs+ssssLpsLsFVl+sA+...o..ohupsshps...phps.ps.spphsh..ps...phss..t..p.ph........................................................................s.s..h...sp....................................................................................................................................................................................................................................................................................................................................................	0	2	7	13
+3312	PF03243	MerB		Alkylmercury lyase	Bateman A	anon	Pfam-B_3505 (release 6.5)	Family	Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate.	21.00	21.00	24.00	29.60	18.90	20.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.70	0.71	-4.30	22	236	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	189	13	65	184	11	118.90	31	52.93	CHANGED	LolpPTsH+hpls..GcpLYsWCAlDsLhass.hlspssplpSpsssTGpslcloVcs.st...lsslpP.sssVVShl.ssss..s...sl+suhCs.hlpFFuo.psApsWhspHP...supllslt-Aa.pLGptlttplh	................hohh.TsHphpls.....u+.pLYuhCAlDoLhhsu.ll.u.p.s..sclpStCssTGpslplolps.s.p......lhslpP..sshsVuhlsssct.s..........shpsuhCs.plp.FFsS.psApsWhsp+s....th..tllslppAa.tlup.h.t..h............................	0	26	44	57
+3313	PF02065	Melibiase		Melibiase	Mian N, Bateman A, Eberhardt R	anon	IPR002287	Family	Glycoside hydrolase families GH27, GH31 and GH36 form the glycoside hydrolase clan GH-D. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K [1]. This family includes enzymes from GH36A-B and GH36D-K and from GH27.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.45	0.70	-5.78	13	2958	2012-10-03 05:44:19	2003-04-07 12:59:11	13	57	1465	71	1044	2993	252	265.70	24	45.35	CHANGED	SFpTPEllhsYospGLNuhSQpaHsLhRp....+lh+statsc.RPlllNsWEAsYFDaNcsplhslA-cA.....tcLGlEhFVLDDGWFGs...RsDDsuuLGDWhlspcKaPsG...Lssluccl........+spGhcFGLWhEPEMVs.s-ScLa+pHPDWllp.sssRstopuRNQhVLDlups-VhDaIhpphspLLspssIDYlKWDhNRplTEssSsths.......ssHpYhLGlYclh-pLsspaPcllaEuCuuGGGRFDhGhLhYhPQhWsSDsTDAl-RlsIQaGTSL............lYPsushGAHVSAsPNcQstRtT.ShphRutVAhh.GshGhELDlspLsccEcptltp.lAhaKchRpllt.....hGshYRLpsPt..su.NpsAhhhVSsDpspAlltahplhussshs..........shl+LtGLDsc	...................................................................................................................................................................t..p..t...P..h.h....h.Ns.........W.p..s....h.........h....h.........c..........h..........s..........c....pt..........l..........h.p....h..A....c..th................tc..h.....G...h.......-.....h..h....l..l..D....DG...Wh.s..t.................R.p..s...c................t....................h.......G...........c........h......h......s........s..........t........p.......+a..P.....s.....G..........lpsLsct.l...........+..sh.G.h.c.F.Gla...h....p....s...................s...........t.........o......t.........h........h...t..t....a....P.....................................................................................................................................................................................................................tt.hh...t.......hta.hKh..D...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................s...............................................................................................................................................................................................................	1	383	695	892
+3314	PF01372	Melittin		Melittin	Bateman A	anon	SCOP	Family	\N	20.60	20.60	21.10	25.90	19.70	20.50	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.39	0.72	-7.01	0.72	-4.59	3	18	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	16	4	1	33	0	24.20	71	40.82	CHANGED	GIGAILKVLoTGLPALISWIKRKRQQ	.GIGAlLKVLuoGLPsLISWIKp.....	1	1	1	1
+3315	PF02964	MeMO_Hyd_G		Methane monooxygenase, hydrolase gamma chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	25.00	25.00	118.90	118.40	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.92	0.71	-4.33	3	19	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	18	54	4	20	0	160.40	53	94.31	CHANGED	IH-NsTRsAWhuKIApLNTLEKAscFIpDFRscHoSPFRsSY-LDlDYLWIEtKIEEKLAVLKs+cFN-sDLlsKsTsGEDApuVtsssVAKMcAAsDKYEAERIHIsFRQAYKPPVMPVNVFLDTDRQLGT+LMELRNTDYYATPLEuLRKcRGVKVVHL	......IH-NssRsEWhuKIApLsolcpAstFlpDFRhpaoSPFRpoYcLDlDa.aIEtKIEE+LuVLKscc.h.ssu-LlTKsosGEDAttVpsshlAKhcAscs+Y.EAERIHIpFRphYKPPVhPVNVFLcTDptLGT+LMELRNTDYYusPLEsLRKcRGVKVlpL.......	0	1	4	4
+3316	PF03203	MerC		MerC mercury resistance protein	Mifsud W	anon	Pfam-B_2720 (release 6.5)	Family	\N	23.00	23.00	23.00	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.74	0.71	-3.72	42	387	2009-09-11 08:49:01	2003-04-07 12:59:11	9	5	300	0	102	277	593	114.30	31	81.69	CHANGED	hD+hulshSsLCslHC...lshPhlhshLsshG.hhh.....hhsphhHphhlslslslullAlhhGhhpH+.phthhsluhhGlslhshuhhh.cshh.....ct...............................................slTllGssllshuHlhNhRhs	..................hD+hGshuSllsAhtC.hshPslsuhuuulG.uhh...............hcs............hah....th..lLslhssluhlA.slGa...hpH+.phh..hhh.L.uhlG.sllhsus..h.....hhhshhh.....ps.................................................................slhhlGhsLhlusplhshh..s......................	0	45	71	89
+3317	PF05052	MerE		MerE protein	Moxon SJ	anon	Pfam-B_5840 (release 7.7)	Family	The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2]. 	20.70	20.70	22.10	21.70	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.66	0.72	-4.00	6	198	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	160	0	22	56	10	73.70	75	93.45	CHANGED	MNSP-+lPsET+..pPlTGYLWGsLAVLTCPCHLPILsh..VLAGTTAG.AFluEaWGIAALsLTGLFlLSloRhLRAF...p	............MNuP-+LPsET+..pPloGYLWGALAVLTCPCHLPILAs....VLAGTTAG.AFlGE..H..WGlAALsLTGLFVLSVTRLLRAF.c........	1	5	9	16
+3318	PF00376	MerR	merR; 	MerR family regulatory protein	Finn RD, Bateman A	anon	Prosite & Pfam-B_3021 (Release 7.5)	Family	\N	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-7.41	0.72	-4.39	347	3063	2012-10-04 14:01:12	2003-04-07 12:59:11	18	35	1779	31	910	13735	1815	37.70	36	21.31	CHANGED	sIu-l.....Ach.s..GloscolRaY-ct.G.Ll...ssp+spsGhRhY	..............sIGcl.....Act.s.....GVsspsl...RaYEpp..G.Ll.....ss.tR..s..s..u..u.hRpY.................	0	354	658	814
+3319	PF02411	MerT		MerT mercuric transport protein	Bashton M, Bateman A	anon	Pfam-B_1796 (release 5.4)	Family	MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic  MerP (also part of the transport system) to mercuric reductase (MerE).	29.30	29.30	29.30	29.40	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.55	0.71	-4.28	3	490	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	366	0	109	326	70	112.50	47	88.93	CHANGED	MSEPpNsRGALFAGGLAAILASsCCLGPLVLlsLGlSGAWIGNLTlLEPYRPIFIuAALVALFFAWRRIYRPVcACcPGsVCAlPQVR+TYKlIFWlVAlLlLVAluFPYVlsaFY	......................psu+u...u...Lh..u.G....s..L.A.AlhASsCClGPLVLlsL.GhS.GA.WI.G....N......LT.s.LE.PYR.PlF.IGs...A.LlAL..h..FAWp+l...Y......R..P..s..p..A...Cc.....P.G.c.lC...A...l...Pp...l.R...t.........s....h...K.llF.W..l.VusLVLluLuFPYlhPaFY.........................................	0	32	75	97
+3320	PF02475	Met_10		Met-10+ like-protein	Mian N, Bateman A	anon	Pfam-B_2239 (release 5.4)	Family	The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast (Swiss:P38793) suggesting this protein may be involved in methionine biosynthesis, transport and/or utilisation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.28	0.71	-4.72	11	1002	2012-10-10 17:06:42	2003-04-07 12:59:11	11	35	540	11	661	9354	2050	197.00	24	47.12	CHANGED	psaslIGDllllplpsEhpp.acphIuEslhchp.slKsVhp+supl..cG.aRshchEllAG.ps.opTlH+ENGspa+lDluKVaaSs+htsERtRlsph.sc-GElVlDMFAGlGPFuIslA+htKschVaAl-lNPcuh+aLpENI+LN..KVcshl.sIhuDsc-Vh...cshAD..............................................RllMshPtpsccFLcp...Ahptl+-G............GVlHY	.......................................................................................................p..athhGc....l..h..h..l..p....h..........t....p..................t....t.....l.....u...p............h...l...h.p....t............t...l...c.s...l...h....p.c....h.s..........h......t..s..t..h...R................p....h.....c....l....l..h.....G....c...p.....................h..............s......h.pE.....p....s..h....p.....a...p...h..........D.....h......s....+.....l.....a....a.....s......s....p............t...s.............E......+........t.......R...l.......s........p................h.......h.........p.........t........s.............-.....s............V..hDh.a..AGl...G..s.....F......u.l....s...h...u.....p...............+....s....t....h.........V...aAs-......lNPp...u...h....c.......hL..p.c........N..h...p.....l..N.......+..l...........p.....s.........h.......l........s.....h.....p...h.....D.....s.....p...p....hh............hh..p........................................................................................................................................................................................+...h..l....h....s..h............................s..........p......h....h.......h....................................................................................................................................................................................	1	209	377	540
+3321	PF02965	Met_synt_B12		Vitamin B12 dependent methionine synthase, activation domain	Griffiths-Jones SR, Eberhardt R	anon	Structural domain	Domain	\N	20.80	20.80	21.50	21.30	19.70	20.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.16	0.70	-11.32	0.70	-5.14	11	2573	2009-09-10 23:08:37	2003-04-07 12:59:11	12	20	2384	10	722	2189	810	252.90	35	25.51	CHANGED	sslpElhsalc.+shap.......................s.t..stcsp+lh.supshLp.........ucslsshLsu.........................................................................u-hhuhFAsTuGhthEchtcshppptD.hpuhllcAlGstlAEAhA-plcccl+pc....stscslsho.........hR.uPGYsuh.-hoEpttlapLlpsEp.hGl+LT-ShhMsPtpSVSGlhhhsPp.u+h.hhuphspsphpDhhtRKth	.............................................................................................................................................................................................................................................h..ltplh.aIDWtsFF..sW..........ph.hG.a....................Ptl..h..pc....G....tA.ppla.t-u....pt..hL.....c.cl.tpphl..........ps+uVhGha.PAspsGDDl.lhtscsppphhth.h.......................................................................................................................pp.thsshsluDalssh.oGhs..DalGh.FAV..TuGhth.-thscta.c.sp..p.DDYstIh.l+ALADR..LAEA......hAEhlHc+VR+c..hW....GYus.sEsLss--Llp.....................ppYpGIRPA.PG.Y.P.A........CP-Ho-Ktsla.cLL..c..........s..-.....c..h.......G......hpL.T.E.S.a.AMhPsuSVSGhYau.H.P.c.....u.....+...Y......F.....u.l..u....p...l.tpD.Q.l.p.c.aAhR+t.....................................	0	250	478	616
+3322	PF03724	META	DUF306;	META domain	Yeats C	anon	Yeats C	Domain	Small domain family found in proteins of of unknown function. Some are secreted (e.g. Swiss:O25998) and implicated in motility in bacteria. Also occurs in Leishmania spp. as an essential gene.  Over-expression in L.amazonensis increases virulence (Swiss:O43987; [1]). A pair of cysteine residues show correlated conservation, suggesting that they form a disulphide bond.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.50	0.72	-4.18	122	2207	2012-10-03 08:47:39	2003-04-07 12:59:11	11	29	1689	2	524	1564	142	100.60	23	59.33	CHANGED	sltsspWpl......h..put.shhs...tpps...pls.........h.tss.................s...plsGp...uG..CNpahGsapl.pss..........p.....lshs....sluuTchuC..s.s.hhphEpthhpsLps.spshpl.p..ss............pLsLps	..........................................................................ttpa.l..........h....p.ut...hs.t.............psts....pls.........h..s..pp...................t....plsGp.....su..CNp..a.....h..Gp...h.p.......l...ps.s..........p.......lphp....sl.u.s.T.c...Mh.C......ss.....p..hhphEpphh.p.hLpp..stphsl.s......ss.............pLhL..t...............................	0	156	334	437
+3323	PF01676	Metalloenzyme		Metalloenzyme superfamily	Bateman A	anon	Pfam-B_1926 (release 4.1)	Family	This family includes phosphopentomutase Swiss:P07651 and 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, Swiss:P37689. This family is also related to Pfam:PF00245 [1]. The alignment contains the most conserved residues that are probably involved in metal binding and catalysis.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null --hand HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.65	0.70	-4.99	27	6157	2012-10-03 20:55:17	2003-04-07 12:59:11	13	22	3518	49	1368	5458	2001	425.30	23	96.34	CHANGED	pphlLllLDGhG.tsspc...tssl..psApT.........PshDplhc.........sspGhtlslP..uphGsS-luHhsl..............huhpstchasspshhtshsc....tt...........Glco+.sclthhsphst.c......hhllhDtR..cl.sppspshhcpltp.pltph........l....s..h...........h.tpuacshhltps....ts.ssshlcs...........lsPphl....stshh.hpss-sl.hhsacsc+stplhptlhppsach.hpptth..t+lh...hh.atuph.ushhh..sstshsph.hchhsppsl+phtluETtphs+lshhas..............h.l.sspGsThslpschpuhthscphlcsl.tsca.D.hlhlNhsssD.hsGHsGchcuplculEthDp.plscll-tltpssshlllTADHGNs.phhs..................TtHTtcPVPlllhut....sh+.......hsphh.tsphAsluuTlhplhGhchsp.hpsh	.....................................................................................................................................................................................................................................................................................................................................................................................................hhLlllD..u...hG...h...stttc................sssh..........tsA.ss.......................s.shsclhpt...s................t.t.p..G...h..s...l.s...LP....sphG.uc.l.u.+hshussphshpshschstthppsphhpsstht.hhthhhssstshhhhshhssttsppp.pthhthhphstttsh.t.h.....................................................................................................................................................................hh.t.httsthhhhpsssshhhhhtpcshthtphhhhhpphttphpttthhhhthhhhhhhssp.sshhth.s.p.s.hss...p..s.p.h.h..s...h...p..t...l..p.p.....h..t...h....u-s.....phu..+.ls..h.asG...............................................................................................s.p.s..h...T...h..c..lp..s..c....h....u..s....h....cl...h..-...th.................l.................c.t.l............p..................p......s......c...............h....s......hl.h.sNhs..shD.hhGH....p....t.............s...h.....p....u...h...h..c..A..l.E..shDp...pl.s.c...l...h....c....t.....l................p.......p......s......s......h......l....l..I..T.A.DHG...N..s.s.phts........................................................................................T.s.H....T....p....p................V.....P.....llh.h..us.............th.p........................s.s.p.l..t.p....t..s...p...h....u..D..l.usTlhphhuhp.sp.hpu.h....................................................................................................................................................................................................	0	517	943	1184
+3324	PF02066	Metallothio_11		Metallothionein family 11	Mian N, Bateman A	anon	IPR000869	Family	\N	21.40	21.40	57.30	56.80	18.50	16.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.18	0.72	-4.09	2	7	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	1	0	7	7	0	54.10	63	100.00	CHANGED	MEFToAhFGsSLl.op.pTppKHNLVssCCCSpsTpcso...SCsCoKCuCcoCKC	MEFToAhFGASLIpop....pTppKHNLVNsCCCSpsspcso...SCsCoKCuCcoCKC.	0	7	7	7
+3325	PF01439	Metallothio_2		Metallothionein	Bateman A	anon	Prodom_1611 (release 99.1)	Family	Members of this family are metallothioneins. These proteins are cysteine rich proteins that bind to heavy metals. Members of this family appear to be closest to Class II metallothioneins, seed Pfam:PF00131.	23.00	23.00	23.30	23.30	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-11.06	0.72	-3.43	23	407	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	153	0	53	379	0	72.40	50	90.61	CHANGED	M.SC.CGu.sCGC..GSu.CKCGssCs.CpMYPDls.pt.soTo..pTllhGVAPpKs...puuEhuss...ussGCKCGusCpCsPCsC	..........MSC..CGGsCGC...GSu.Cp.CGss......ssKMYPDls.pt...soTo...pTllhGVAPpKs..phE...u.s.....Ehusst.....sssG.....C.K.CGs.sCp.C.s.PCsC................................................	0	2	22	40
+3326	PF02067	Metallothio_5		Metallothionein family 5	Mian N, Bateman A	anon	IPR000966	Family	\N	25.00	25.00	25.60	25.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.01	0.72	-3.91	2	57	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	16	0	28	47	0	40.30	57	94.64	CHANGED	MsC..CGosCpCuuQtstssCsCspDCpCsscptststCsp	MsCKuCGTNCpCoupK.CGsNCuCspDCpCsCKN.GPK-pCCp....	0	4	5	19
+3327	PF02068	Metallothio_PEC		Plant PEC family metallothionein	Mian N, Bateman A	anon	IPR000316	Family	\N	26.80	26.80	26.80	29.50	25.60	26.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-10.77	0.72	-3.61	4	37	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	20	3	16	36	0	72.90	53	73.21	CHANGED	GCDD+CGCssPCPGGsuCRCsSu...puuuGstEHpsCsCGEHCGCNPCsCs+spspsSG+u..+ApCoCGsuCsCASCAS	..........hCs-+CGCslPCPGGs......sCRCsus.....tuuu.Gs.s-HsTCsCGEH.CGCNPCsCsKs..tsoGpG.....CpCGsuCsCAoCu....	0	2	11	13
+3328	PF02069	Metallothio_Pro		Prokaryotic metallothionein	Mian N, Bateman A	anon	IPR000518	Family	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.47	0.72	-4.14	13	100	2012-10-05 18:33:37	2003-04-07 12:59:11	11	1	96	1	39	94	51	47.90	40	73.21	CHANGED	oTsTphKCACssChCsVohssAlp+-GKsYCSEuCAsGH.hsspGC....GHsGCsC	................pCACssCsChVs..scAlp+-G+hYCscuCAsGH..psps.C....tpssCtC.........	0	8	21	32
+3329	PF00131	Metallothio	metalthio; 	Metallothionein	Sonnhammer ELL	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.81	0.72	-11.32	0.72	-4.09	21	581	2012-10-05 18:33:37	2003-04-07 12:59:11	15	4	201	21	109	522	0	58.90	56	96.13	CHANGED	.DP......CsCtc.susCsCus.uCp.CpsC+CssCcKss.ssCssuGC...sKCu..psCsCtt......t..pCoCCs	......MDP......CsCsp....uG...oC..sCuu..S...CK.C.c.sC+C.....TS.C.KK..S.C..C.uCCPsGC....sKCA...pGC..l..CKG......tspcCSCC....................	0	14	17	30
+3330	PF01717	Meth_synt_2	Methionine_synt; 	Cobalamin-independent synthase, Catalytic domain	Bashton M, Bateman A	anon	Pfam-B_1909 (release 4.1)	Domain	This is a family of vitamin-B12 independent methionine synthases or 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferases, EC:2.1.1.14 from bacteria and plants. Plants are the only higher eukaryotes that have the required enzymes for methionine synthesis [1]. This enzyme catalyses the last step in the production of methionine by transferring a methyl group from 5-methyltetrahydrofolate to homocysteine [1]. The aligned region makes up the carboxy region of the approximately 750 amino acid protein except in some hypothetical archaeal proteins present in the family, where this region corresponds to the entire length. This domain contains the catalytic residues of the enzyme [2].	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.06	0.70	-5.46	14	4790	2012-10-01 21:20:02	2003-04-07 12:59:11	13	9	3434	28	1233	5086	1353	308.90	33	54.56	CHANGED	hPTTT.IGSaPQTsclRcsRtphppuplu..tpYpsth+ttIcpslchQEclGlDVLVHGE.ERsDMVEYFupplsGh.shTtsuWVpSYGSRsh+Pshhhuclptspsholc.thhupshsscs..VKGhLTGPlTILsWSFsR...pD.s+cshshQlAlAL+cElt.cL-sAGhtlIQlDEP...ALREGlPLpp..tc.stYhpWultuFRlssssstscsQlpoHhCYSpassIh...stIsshDsDVloIEtu+sc.phlsslpc.htas+plG.GVaDlHSP.+VPSsEEltshlpcshch.........h.t-pLWVNPDCGLKTRshpEshsuL+NMVcAAct	.....................................................................................................................................................hPTTT..lGSF..Ppop..p.....l.......+..p.....h.......R..........t..t........a.......p...............p..G..p......lst...ppapphhp...........ppIpphl......phQEclGL.D.VllcG....Ehc..R....s....-..............h.Vp.a...F.u...E.p....L.........sGa....h..............h.......s..............p....p...............u.............a..........V...............Q......u....a.............G................s................+................s.............s....+.....s.............P...l..........l....h.....G...-.l........s....p...s.....p..s.....h..........s.......V...c......h.....s......p.a.......u.p.....u.h....T.s+s...............h..Ku.....h...L......T..G......P......s......T.....l....l.....s....h.....o.a.....sR................pt......s...pc....p.....hst..........p.l...A...h.....A.....l...+-El.t......cL.c.s..A.......G.l............p.l.......I.QlDE...s........................Al..+..E.t.....l.....Ph+p..............tc...h....p..t...a.....L............p......h........u............l........t.......u........a...........p............l.......s....p..........u......s....s.........t..........s..........c.....s......p..........I..p...T..........H.h..C...........Y..................u..........p...........F...........s..........shh.................st.l..s.....s..h.....c..s....Dl..l...o.....l..E..s...u....c....S....c.............h.............p.............h...l..........c...sh.....c......p.....h........s..h....s..p..c...l..G.....GVh..D....l.+....S....P.....c....l...P....s.....h.-..c..lt..s.h.l.c.cu..hph..........................lsh..c..pl...alsPD............CG.......L........p......o......p.......t......h.............ps......h.....tt.Ltthltssp.t.......................................................................................................................	1	360	749	1029
+3332	PF01035	DNA_binding_1	Methlytrans; Methyltrans; Methyltransf_1; 	6-O-methylguanine DNA methyltransferase, DNA binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1191 (release 3.0)	Domain	This domain is a 3 helical bundle.	21.30	21.30	21.50	21.40	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.97	0.72	-4.24	93	7975	2009-09-12 05:33:12	2003-04-07 12:59:11	15	49	4422	25	1944	5717	2191	84.40	39	44.75	CHANGED	osFpppVhpt...ltp.IPhGplsoYuplA....ctlG.p.....spuuRsVGpAh...spNP....hshhlPCHRVlsusGp.......lusa....th........uhth..Kp.tLLptEuhth..p	................................osFpppV.Wps.Lpp..IP.hGpshoYuplA................ptl.G..p................P.p..A..sRAVG...s...As........upNP.................lul.ll..PCHRVlsssGp.........L.s.Ga..........ss......................Gl.pc..Kp..tLLphEuh...t...........................................	0	624	1221	1628
+3333	PF02870	Methyltransf_1N	Methlytrans; Methyltrans; 	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1191 (release 3.0)	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.44	0.72	-3.38	11	2628	2009-09-14 13:10:39	2003-04-07 12:59:11	10	12	1908	11	442	1666	131	76.10	23	35.10	CHANGED	tlhaohhcoPlGplhlsssEcs.lptlthtspshs......h.t..phhhts-......hsshthhppplcpYhAuptp.....thslPlch	....................................t.hhhthh.soPlGtlhl.s.s...s-....p.....u..Ls.ulha..tspptp.............h.ph..ph..h...t..sc......................ts...h....t..th...p...p.....pLcc...YFuGppp......hslPls..............................................	0	118	236	347
+3334	PF00891	Methyltransf_2	Methyltransf;	O-methyltransferase	Bateman A	anon	Pfam-B_152 (release 3.0)	Family	This family includes a range of O-methyltransferases. These enzymes utilise S-adenosyl methionine.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.42	0.70	-5.18	30	3396	2012-10-10 17:06:42	2003-04-07 12:59:11	13	42	1164	67	1586	4681	447	220.60	22	62.75	CHANGED	tps.........phYshsssuchLhsspss...sshsshhhhhtspshhpsWtpLp-..ulh-Gt.....ssFpcsaGhs..ha-ahus.Ds...chsphFspuMssssslhs.hchhpshpsFpslsolVDVGGGsGsssptIsptaPpl+uhsFDLPcVltsAss.......tssVcaVuGDhF.-slPp..ADAllLKalLHDWuDpcClclL+pChcAls...tpG+VlllEsllspssssshps...........hhhDlhMlshss.G+ERoccEacpLhp	.........................................................................................................................tttt......................h..................................................................h.............h.............h...tp.......h........p..st...................s..h.t...h..h.h...s....s....ha.ph...h.t....p...p.s..........phtp....h.......F..t......p..u.M.......t.........s..............s........t.........h...........h........h...............................h.......h.................t....h.........h.....s.....h.........p...........s......h........p................p.............l..l.DV.....G...G.G.p...G....t.h...h...t..t.l..h....p.....t....a..........P....p.......l.......c......s....h.....l..h...D.....L.....P...p.....V.....l...t.t..utt.................................ts.p.l...p...h..h...u...u...D...h.....F.....p.........s.......l......P.........t......u.......D.........s.....h......h...h.p.....h.............l....L.............H..c...........W.....s....D.....c....p.......s...h.p...l...L.ppst.p.A...hs........t.........u...+...lllh..-h.l...h..sp...t.....t...t.....t..............t..t......................................h.h.c.h.h..M..hshhs...Gp.....pRs.tcattlh.................................................................................	0	329	890	1294
+3335	PF01596	Methyltransf_3		O-methyltransferase	Bateman A	anon	Pfam-B_749 (release 4.1)	Domain	Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase Swiss:P21964, caffeoyl-CoA O-methyltransferase Swiss:Q43095 and a family of bacterial O-methyltransferases that may be involved in antibiotic production [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.17	0.71	-5.27	8	3858	2012-10-10 17:06:42	2003-04-07 12:59:11	12	23	2673	61	1074	4599	1860	191.10	25	85.30	CHANGED	h-oSsh..Es-hL+ELR-tTs+pP..hstMplss-EGQFLuhLl+LhsAK+TLEIGVFTGYShLssALALP-DG+IsAhDlscEshplGhsaIQKAGVscKIshhlGDAhpsL.-pLhp-cp..spFDFsFlDADKsuYspYaE+hLcLVKsGGLIAhDNTLWtGpVs-s.-sssP-shp.....lhchNchLusD.RV-IuhLslGDGITLsRRl	.................................................................................t...................................................h...........l.s...p..p.u....p..h.L.p.h..L...l.....c...h..h...p....s...+....p.....l......L...E.l.G.....T.hs.G...YSu....l...h.....h...A...p.......u..............l...........s........p........s............u.........c.....l......s...Tl....-...h.........s..t.........c........h....h...p..........h......A........+....p......h.p....c......u....s...........h......p......p...........c.................l...p...l..h............G.......s..A.....h..-..s......L......s.....p.............L...h..........t...........t............................s...a...........Dh.l......F............l.D............u........s..K............s.......p........Y...h......p......a.....h........p.......t..h..l..........p..........L.........l.c....s..G.G......l....l......l.s......D......Nl...............l....h......t......G.....t.....l....hp......t..........t........p..t.t......................lpph....c...h...l....h...p....p....p...hp...s.s.hl.sls.....DGlh.h.h..t................................................................................................	0	347	681	901
+3336	PF02390	Methyltransf_4		Putative methyltransferase 	Bashton M, Bateman A	anon	Pfam-B_1023 (release 5.2)	Family	This is a family of putative methyltransferases. The aligned  region contains the GXGXG S-AdoMet binding site suggesting  a putative methyltransferase activity.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.20	0.71	-5.26	19	4759	2012-10-10 17:06:42	2003-04-07 12:59:11	12	26	4414	24	1194	8689	3879	194.50	28	77.49	CHANGED	hP........ph..........Datphasp.s...........................lhlEIGsGhGshllshApppP-h.alGlElchsslttshp+htph........thpNltllptsAhphhpphhs.spLp+lhl.FPDPW.KpRH+KRRllpsphlpthtphLt.GGhlhhtTDspshhc.hhcthpp.............................shhphh................pss-h..sPhs........s.htssTchEp+shptstslaphhFp+h	........................................................................hs.htt............hchp.p.h.F.s.p..ptP...........................................lhlEIGhGhG....phl....s.......t.h..........A.....p........t....p...P..-.........h.........s..a.l.GlEl.....p.ps..sl...s.....t.....s..L..pp.h.tct............................................................sl.s.N.......l..+..l..l....p...t...D......A....h.....c.....l......L...p.....p...h.....h...s......p......s....p.....l.s....p..l..a...l.....h...F........PD..P..W.....K....p....R.Hp.............KR........R...........llp.....sFlphhtph..L.p.........s..............G.....hl....+.ht...T...D..csh.h.cahL.cshsp........................................................................t..hp.t.h..................................................s...c..h.........s...s.h.............t...p.shTcaEp....+hpp.t.Gpslaclhh...h......................................................................................................................................................................	0	408	771	1016
+3337	PF03737	Methyltransf_6		Demethylmenaquinone methyltransferase	Bateman A	anon	COG0684	Family	Members of this family are demethylmenaquinone methyltransferases that convert dimethylmenaquinone (DMK) to menaquinone (MK) in the final step of menaquinone biosynthesis. This region is also found at the C-terminus of the DlpA protein Swiss:Q48806.	20.70	20.70	22.30	21.90	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.54	0.71	-4.35	11	3287	2009-01-15 18:05:59	2003-04-07 12:59:11	10	22	1989	41	1060	2581	1112	153.90	30	75.23	CHANGED	pphsTssLsDshst.sssspPhhss...hstpsphsGpssTV+shp..............DNsLl+pslppsutGcVLVlDGtGsh..........cpAlhGshluthAtppGhpGlVlaGslRDlsslcpLDlslhAhussPst..usppuhGp..lsVslshuGVT..lpPGDhlhuDssGllV	............................................................................................sstl.D......h................p.....h.....t....h..h.p.......s...hps.......hss..p...s.p...h.sGphhTV+sht..........................DNs..h....l....p..c..hl.....-..p.....s.s........t........G...c..VLV...l...D..u....s.....G.s.h.....................cp.A..l.hGs.hl.A.p.h.A.h.p.p.Gh....t.GlVlp.G.u..VRDlspl.p.p..h.....s..ls..l..h.A.h..u..s.h.Phs.................s.s.p..c...u..h.G-.............hsls..l..........s..................h..........G...................G.......ls................lhPGD.hlhAD..s.sGll..............................................	0	248	604	862
+3338	PF03492	Methyltransf_7	Methytransf_6;	SAM dependent carboxyl methyltransferase	Bateman A	anon	Pfam-B_1148 (release 7.0)	Family	This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-Methylxanthine. Caffeine is synthesised through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N.  The protein 7-methylxanthine methyltransferase (designated as CaMXMT) catalyses the second step to produce theobromine [1].	20.20	20.20	20.30	20.90	19.80	19.30	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.15	0.70	-5.68	23	707	2012-10-10 17:06:42	2003-04-07 12:59:11	10	4	157	8	380	728	190	269.90	29	87.55	CHANGED	lppslpph....h.ts...hssslslADLGCSSGPNTFhslssIlcslcpphppps.....tssPEaplahNDLPsNDFNTlF+hLP.h..................tphFsuGVPGSFYGRLFP+pSLHhsaSSaoLHWLSpVPctlp-p.s..h.....NKuplahs.........pVh+AYhsQFpcDhshFLcsRuEElVsGGhMlLshhGRps.......D.ssptss..hhh-LlupuLsDlspEGll---KlDoFNlPhYsPsspEl+thI-cpGSFpI-chEhhp.....h..p....................tsucthusshRAlhEshLssHFGpslh-clFc+atp+lspph.hpp...p.hhsllluLpRp	..........................................................................h...................sp.hhlADLGCSsGsNohhhlppllphlpphhpp.t....................chphhhNDLssNDFNslF.p....t.L......sth.t....t........................shahsu...l.PG.SFY.s.R.LFPppSlchhaSuhu............Lp.W.L.....Sp........l.............P..ptl..s................................Ncsplahs..sss.....tlhpuYhpQappD.h.p.FLphRupElhs.GGthllsh..h.u+ps.................p....p.t.t.ts............hhp....hl...ttulpph.........stc....G........hl....pc-ch.-sFslPh....Ytso.pE.l...ct....hlpp.....p....u...p......F...p...l.p...p.hc..hhp..............h...................t.........................u.thu.th.hR.uhhpsh.l.......t...p.....h.....G........t.......t........l....h.c.tlFtphtphhtt......................................................................................................................................	1	54	213	296
+3339	PF02086	MethyltransfD12		D12 class N6 adenine-specific DNA methyltransferase	Mian N, Bateman A	anon	IPR002294	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.83	0.70	-4.93	27	3733	2012-10-10 17:06:42	2003-04-07 12:59:11	10	25	2224	21	654	3159	1250	233.30	24	80.29	CHANGED	ahGuKppLlspIpchlPp......ptppah-PFsGuGuVhhph......phtpslhNDlps.lhslap.llcs.........scpllpphp.h....hh..p..ssp-hahph+............pchN....pshp.h.c......sh.hhhhsthshsslhphsppupasssaGtatp......hhstpplpthsptlps.....sphhstsh-tshhhh.phts.hlYhDPPYtshp.tssapsapp.shspppphthtshhcpht....tphthphhlsss.......ssp.hcclaps...hslhphpthpsl	...................................................................................................ahGuKhtLhsp.l.......hp...h.lP....................ptpph.lEPFsGuG..uV.hh.ph...............php.p..h..l.l..s..Dlssc..Llsl...a.p.....hlpp.............................pspp.h.l...pthcth....................h..............s...p.pc.h.ah..ph+...............................................................................................pphs............p.th..p...h.c..........................uhhhh.a..l.s...+.h..s.....a.......sG.l..h......c....h....s........h.......p....u......p.....h........s..s....s.....h.....u.....p.apps....................hhs....p...p....p..l...h.t...h...s...p..p..hpp......................sthhst..s.a......p..........p.....s...h......t............t......h..............t.......t......s.....s.......l..lY.h.DPPY......h.s..........................ts............s....a..p.......t.....a....p..t.t....s.a.s.........p.......p....p..h..p.L....t..p....h...h.pph................t.th...h...hlSsp....................ss..h+phapt......th........................................................................................................................................................................................................	0	232	454	559
+3340	PF01340	MetJ		Met Apo-repressor, MetJ	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	31.60	31.50	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.33	0.72	-4.28	3	798	2012-10-02 18:44:02	2003-04-07 12:59:11	15	1	794	30	96	197	8	102.70	87	97.11	CHANGED	AEWSGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPDDADLRKERSDEIPEAAKEIMRELGIDPETWEY	.....AEWsGEYISPYAEHGKKSEQVKKITVSIPLKVLKILTDERTRRQVNNLRHATNSELLCEAFLHAFTGQPLPsDsDLRKERSDEIPEAAKcIMREMGIsPETWEY..............	0	12	33	66
+3341	PF04648	MF_alpha		Yeast mating factor alpha hormone	Kerrison ND	anon	DOMO:DM04511;	Family	The hormone is excreted into the culture medium by haploid cells of the alpha mating type and acts on cells of the opposite mating type (type A). It inhibits DNA synthesis in type A cells synchronising them with type alpha, and so mediates the conjugation process.	19.00	19.00	24.60	19.20	17.90	16.20	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.97	0.73	-6.12	0.73	-3.43	3	152	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	27	0	59	116	0	13.00	78	26.85	CHANGED	WHWLSl+PGQPMY	WHWLpL+PGQPMY.	0	6	30	45
+3342	PF04202	Mfp-3		Foot protein 3	Bateman A	anon	Pfam-B_1860 (release 7.3)	Family	Mytilus foot protein-3 (Mfp-3) is a highly polymorphic protein family located in the byssal adhesive plaques of blue mussels.	20.70	20.70	21.60	23.10	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.69	0.72	-3.80	2	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	5	0	1	49	0	71.80	63	96.17	CHANGED	MNNoSVSVLVsLVLIGSFAVpSDAAsYYGPNYGPPRRYGG..YNtYNRYuRtYGG.+GWNpGWpRGhRG+h	..MNNhSVuVL.lALVLIG.FAVQSDA..u.......hhYsPsYssPh.YssGh..Y..NGYNtY.tt...RYGhNKGWNsG.W...................	0	0	1	1
+3343	PF01078	Mg_chelatase		Magnesium chelatase, subunit ChlI	Finn RD, Bateman A	anon	Pfam-B_616 (release 3.0)	Family	Magnesium-chelatase is a three-component enzyme that  catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of  (bacterio)chlorophyll.  Due to this, it is thought that  Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.14	0.70	-5.16	56	4229	2012-10-05 12:31:08	2003-04-07 12:59:11	16	28	3288	9	1225	9364	2476	172.30	42	36.05	CHANGED	DhsDV+GQppA+RALElAAAGGHNLLhlGPPGoGKoMLApRLPulLPPLotpEuLEsstItSluG..thptshhppRPFRuPHHouStsALlGG..Gs.hs+PGElSLAHpGVLFLDElPEFsRplLEsLRpPLEsGclsIoRAptpl.saPAcFQLVAAMNPCPCGahucssptCpCo..spphpRYhu+lSGPLLDRIDlplcV.stlshtpL	.............................................................................................Dht-lhGQ....t....p...u....+....R....A....l....c...l....A...A.................A.............G......t.......H.............s...l..l..hhG..sPGsGKoM.LApR.l......s....s......l......L....P.................s..............h...s.....................p............E............h..l............E...........s..s.......t...........l....h.........S.......ls.......s..................................t.....t.......h...t...p.t..............P..F...Rs....P.........H..........H.....os.........S.............s.A..l........l...G.......G..................G...........s...hspP..G.....E.l.o...L....A....H.p..G....V.LFLDEl...sEF...pcplL.-s.L.R..pPl.Es..G..p.l.p.lu....R.s.t....t........p....l........p........a....PA+F.LluA.hN.....PsPsG....h..t...t.....t......t.t..C...s.........stph.cY.s+..lS..GPhlDRhDlplph.......h...................................................................................	0	414	845	1059
+3344	PF05043	Mga		Mga helix-turn-helix domain	Moxon SJ, Bateman A	anon	Pfam-B_5126 (release 7.7)	Domain	M regulator protein trans-acting positive regulator (Mga) is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1]. This domain is found in the centre of the Mga proteins.  This family also contains a number of bacterial RofA transcriptional regulators that seem to be largely restricted to streptococci.  These proteins have been shown to regulate the expression of important bacterial adhesins [2]. This is presumably a DNA-binding domain.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.76	0.72	-3.70	33	5627	2012-10-04 14:01:12	2003-04-07 12:59:11	8	55	1351	2	389	3825	25	88.20	19	15.90	CHANGED	tshshpplhphhhcc...............ShphplLphlh..tpcphslpphupchalSpoolhRhlcclsphLp.paslpl.....pssplh.GcEhpIRhFahhLa	.........................................................................t..............pp..................phph.h...l.l..phl....h......tppth..shp..p.lspchhlScuTl.h+clppl.p.p.h.Lp...pa..s..L..pl.........ttps...h..p..l..h..GsE.hpl.Rhhhhph....................................	0	126	235	307
+3345	PF05220	MgpC		MgpC protein precursor	Moxon SJ	anon	Pfam-B_6685 (release 7.7)	Family	This family contains several Mycoplasma MgpC like-proteins.	18.30	18.30	21.50	24.60	17.90	16.50	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.49	0.70	-5.23	3	49	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	7	0	9	57	1	203.40	69	29.95	CHANGED	MGSstVPSLWYWVV...uE-ssSGKuTWWA+TELNWGTDKQKQFVENQLGFKETSuTDSHN..FKupuLTQPAYLISGLDVVADHLVFAAFKAGAVGYD...MTTDSSASTYNQALAWSTTAGLDScGGYKALVENTAGLNGPINGLFTLLDTFAYVTPVSGMKGGSpNTEsVQTTYPVKSDQKATAKIASLINASPLNSYGD-GlsVFDALGLNaNFKhN-ERLPSRTDQl	.....MGsshlPSLWYWVV...upcssSsKsTWaApTpLsWGpDKQKQFVENQLGaK..-souosSHN..F+SpuhTQPAYLISGlDsVsDpLlFuuFKAGuVGYD......So.SSuS...TKDQALAWSTTsuLDScsGY+sLVpNssGLNGPING.Fol.DTFuaVsPhSG.+sss.ts...o.tslpTsYPVKsspKuTsKIsSLINAoPLNSYGD-G...lsVFDALGLNaNFK.NpE+Lspt................................	0	8	8	8
+3346	PF02308	MgtC		MgtC family	Bateman A	anon	Bateman A	Family	The MgtC protein is found in an operon with the Mg2+ transporter protein MgtB.  The function of MgtC and its homologues is not known.	23.00	23.00	23.20	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.71	0.71	-4.32	11	3455	2009-09-11 06:02:09	2003-04-07 12:59:11	11	7	2432	0	775	2251	137	132.60	37	56.32	CHANGED	LllAhllGulIGLERphRt...+hAGLRTpsLlAhGuslhsllSlpsthshs.........PsRlsAQllSGlGFLGuGsIL+cu........sslpGLTTAAolWsoAulGllsGuGhaphulhuolhlLh..lhLpslsphlp+p.hp	.........................lhlAhllGulIGhER..p.h.....+p..................+s.AGlRT.ahLVu.lGuslh...h......l.....l.u.......hh....s....h....t.s....h..........................DPsRlu...A....QVV....SG.l.G.F...L.G.A..G..s.I..l..h.ps...............................ps.l.pG...L.TTAAslWsoAulGls.h..G.s.G..h......ahhA.lhusl.h..ll.h.s.h.hh..lp...ltp.......hht...................................	0	254	503	630
+3347	PF03448	MgtE_N		MgtE intracellular N domain	Bateman A	anon	Bateman A	Domain	This domain is found at the N-terminus of eubacterial magnesium transporters of the MgtE family Pfam:PF01769. This domain is an intracellular domain that has an alpha-helical structure. The crystal structure of the MgtE transporter [1] shows two of 5 magnesium ions are in the interface between the N domain and the CBS domains. In the absence of magnesium there is a large shift between the N and CBS domains.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.29	0.72	-3.70	169	3637	2012-10-02 13:19:07	2003-04-07 12:59:11	12	24	2860	12	968	2783	1850	101.10	22	23.58	CHANGED	hcssDlAcllp......pl...s..ccphtlhphL.stcptu-lhppls.tc.hptpllpph..sspphsp.llpphssDDtsDl...lpcLspct.tpplL...sth.stcc+pplppLLsYs-c	.....................................................pssDlAphlc......pl......s..cp....ph..hlh.ph.L....ss-p...tu-ll.p..pl...s...pc...hp...tpl...l...p...p...h...sspchu.c...llp...phss..D..-ss-l...lpcL...s...p.sh....hp...pl...L...s.th...s.cctpplpp.lLp.Ys-p...........................................	0	358	675	840
+3348	PF03165	MH1		MH1 domain	Bateman A	anon	Pfam-B_519 (release 3.0)	Domain	The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however.  Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [1,3].	25.00	25.00	25.20	27.80	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.70	0.72	-4.03	19	1320	2012-10-05 18:28:12	2003-04-07 12:59:11	11	19	119	10	608	1055	0	101.20	42	22.56	CHANGED	hc+sscuLlKKLKc+.....tL-sLhpAlpspGsss..................otClsls..............................+ph-uRLt............st+KuhPHllhC.....RlaRWPDLpptpELKslssCpts.hp.cpcp......lClNPYHYpRlp	................................................................t.pKhspsLl+KL+Kch...tthE-L.pAlo.....s....ps......................stCls.ls....................................................................................................p..h.ph.ts....................scpKGhP+lIhC..............+l..WRWPD..Lp..t..tELK...s...lt.h.C.phs..hphppst.............lC....lNPYHapRl......................	0	141	193	390
+3349	PF03166	MH2		MH2 domain	Bateman A	anon	Pfam-B_519 (release 3.0)	Family	This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2 [1-3].	25.00	25.00	25.10	25.00	22.20	24.60	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.32	0.71	-4.46	11	1087	2012-10-01 21:55:46	2003-04-07 12:59:11	9	17	139	31	549	937	0	167.40	50	39.60	CHANGED	hpcsphWsoIuYaEhssRVGEha+lsss...slhlDGas....Dss..sssRhCLGtLoNsNR..ssslppsRt+IGcGVpLshc..sGp..ValpspScpsIFVpSsshshptG.hc.s.pVpKlhPs.solKlF-hphhtpllppssppu.tu..................................stpLp+.hColRlSFVKGWGtcY.pRQslpuoPCWlEl+Lsts	...............................................................h.-PtaWCSIuYaE....hssRVGEsF+ssps.......ol.hlDG...as................DPS.....susRF..CLGhL...S.........N..V.s...R..............spslEp.sR.pHIG.+............G...VpLhhh..sG...-........VascC.l...S.............-.puIFVQ......S............sh.s..p....t.......G.....h...........+Ps.......s..........Vp...........K.......I.....................PG.........s.............s....l...K...............lFs.pc...htthh..tpss....s.p.u...ts...........................................................................V.pLp+.hC.ol.RhSF.VK.GW.G.s....-Y..pRQslouTPCWlElpLpt.s................................................................	0	143	186	378
+3350	PF00129	MHC_I		Class I Histocompatibility antigen, domains alpha 1 and 2	Sonnhammer ELL	anon	Prosite	Domain	\N	28.30	28.30	28.40	28.30	28.10	28.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.17	0.71	-4.93	25	25261	2012-10-03 22:02:01	2003-04-07 12:59:11	13	14	308	732	732	17686	0	155.50	62	74.51	CHANGED	GSHSLRYFhTAVSRPGhGEPRFIuVGYVDDTQFVRFDSDAtsPRhEPRAPWhEQEG.PEYW-RpTphuKuptQsFRVsLRTLhuYYNQSEuGSHTlQhMaGCDlGsDGRLLRGYpQaAYDG+DYIALNEDL+oWTAADsAAQIT+RKWEtAshAEp.tRAYLEGpCVEWLRRYLEpGKETL	......................................................................SHShRY..FhTu..h.S..RP..G..R..G..EP...R..FIu.V.G.YVDDTQF.VRF....D...S...D.A.s.S..........R.h.E..P.R...A.PW...l.....E....Q.....E.G......PE..Y.W...........D...c.p.T..ph.h.K...s.p.sQ...s..R.s.L.p.s....L..p.t.Y..Y.N..Q..S............E............u.......G............S............H......Tl.Qh.MYG.....CD..l...G....s...D...G....R...h.LRGapQ...AYDG+D..YIAL..N.E.D..L..+.SW.....T....A.....A....D.....h..A.....A....Q....I....T.......p...R.........K...W....E.......A..A...c.....A..EQ....h.......RAY...L.E.GpCVE.......WL....RR...YLENGKETL......................................................................................	0	92	131	319
+3351	PF03707	MHYT	SPNTR; 	Bacterial signalling protein N terminal repeat	Yeats C	anon	Yeats C	Repeat	Found as an N terminal triplet tandem repeat in bacterial signalling proteins. Family includes CoxC (Swiss:Q9KX27) and CoxH (Swiss:Q9KX23) from P.carboxydovorans. Each repeat contains two transmembrane helices. Domain is also described as the MHYT domain [1].	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.17	0.72	-3.86	27	2404	2009-01-15 18:05:59	2003-04-07 12:59:11	11	83	683	0	856	2299	124	61.50	27	23.87	CHANGED	GhGIhuMHasGMhAhph.........s..h.ap.hhhh.hSll....lultssssul.hhshttthhhthhhsusll	...............GhGIhuMHasGM.hAhphs...........................st..ltas...hh.......h.......s....h...l...Sll.............lA.l.ss.u.h.hAL....hhs..h..t....t.h............h.......................................	0	190	449	678
+3352	PF02426	MIase		Muconolactone delta-isomerase	Bateman A	anon	Pfam-B_2784 (release 5.4)	Domain	This small enzyme forms a homodecameric complex, that catalyses the third step in the catabolism of catechol to succinate- and acetyl-coa in the beta-ketoadipate pathway EC:5.3.3.4. The protein has a ferredoxin-like fold according to SCOP.	20.10	20.10	20.40	20.20	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.95	0.72	-4.17	7	493	2012-10-02 00:20:33	2003-04-07 12:59:11	11	4	392	0	136	363	26	90.60	44	92.14	CHANGED	MLFpVcMsVplPssMss-tAsplKucEKAhSQcLQ+pGKW.HlWR...lsGcYuNlSlFDV-SssELHplLtsLPLFPYMsIEVpsLsRHPSul	.............................................MLFhVcMsVpl.Psshssptsscl+AcEKshuQcLQcpG+Wh+LWR...ls.G..pYuNl.SlFDVcsssELH.s.l.Lp.uLPLa....P..a.M....sI.cV.ssLspHPSsl..................	1	29	70	109
+3353	PF03526	Microcin		Colicin E1 (microcin) immunity protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	25.00	26.40	23.70	24.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.50	0.72	-4.37	3	96	2009-09-10 20:23:55	2003-04-07 12:59:11	8	1	70	0	2	41	0	48.70	45	43.97	CHANGED	YYFLASDKMLYAIVISTILCPYSKYAIEHIAFKFIKK-FFc+RKNLNssPsAKls	..hhhh.hhhh.................lLaPhuKahIEchAlKFT+.-FWpps..FFssssGKhs.......	0	1	1	1
+3354	PF04687	Microvir_H		Microvirus H protein (pilot protein)	Kerrison ND	anon	DOMO:DM04728;	Family	A single molecule of H protein is found on each of the 12 spikes on the microvirus shell.  H is involved in the ejection of the phage DNA, and at  least one copy is injected into the host's periplasmic space along with the ssDNA viral genome [1]. Part of H is thought to lie outside the shell, where it recognises lipopolysaccharide from virus-sensitive strains [2].  Part of H may lie  within the capsid, since mutations in H can influence the DNA ejection  mechanism by affecting the DNA-protein interactions [3].  H may span the  capsid through the hydrophilic channels formed by G proteins [1].	21.30	21.30	36.80	61.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.93	0.70	-5.38	3	108	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	1	127	1	300.50	78	94.51	CHANGED	MGKLFGGGQSAsSsGIQGsVLAoDNNsVGMs.DAGIKSAIQGSNVPNSsEAAPStlSGlMA.......cAGKuLL-GTlQAGostVusKLlDtVGLGGKSAuDKGKDTRDYLAAAFPELNPWERAGAGASSuGlpDAGFpNQKELTKMQLDNQKEIAKMQNETQKEIAGIQSATSRQNTKDoVYAQNEMLAYNQKESpARVASILENTsLTKQQQTSEIMRQMLTQAQTAGQYFTNDQIKELTRKVuAEIDtVH..............Q-TQNSRYGSSQVGATAKDVSNsITDAASGlVDaF+GhDptVADsWNNFFKDGKScGIuSNpR+	............MSKLFGGGQpAASuGIQGsVLATDNNTVGMs.DAGIKSAIQGSNVPNscEAAPshlSGsMA.......cAGKuLL-GslQAGostVo-KLlDhVGLGGKSAADKGKDTRDYLAAAFPELNAWERAGAsASSAGMVDAGFENQKELTKMQLDNQKEIAEMQNETQKEIAGIQSATSRQNTKDQVYAQNEMLAYQQKESTARVASIMENTNLSKQQQVSEIMRQMLTQAQTAGQYFTNDQIKEhTRKVSAEVDLVH..............QQTQNQRYGSSpIGATAKDISNVVTDAASGVVDhF+GIDKAVADTWNNFWKDGKADGIGSNLSR....	0	0	1	1
+3355	PF04726	Microvir_J		Microvirus J protein	Kerrison ND	anon	DOMO:DM04878;	Family	This small protein is involved in DNA packaging, interacting with DNA via its hydrophobic carboxyl terminus.  In bacteriophage phi-X174, J is present in 60 copies, and forms an S-shaped polypeptide chain without any secondary structure.  It is thought to interact with DNA through simple charge interactions [1].	19.00	19.00	21.40	46.90	17.80	16.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.72	0.72	-6.88	0.72	-3.99	3	63	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	53	4	0	16	2	30.40	78	97.41	CHANGED	pKutRRSG.............GKRKGARLWYVGGoQF	...pKut+RSG.............GK+KGARLWYVGGpQF	0	0	0	0
+3356	PF04517	Microvir_lysis		Microvirus lysis protein (E), C terminus	Kerrison ND	anon	DOMO:DM04358;	Family	E protein causes host cell lysis by inhibiting MraY, a peptidoglycan biosynthesis enzyme.  This leads to cell wall failure at septation [1]. The N terminal transmembrane region matches the signal peptide model and must be omitted from the family.	25.00	25.00	50.50	49.90	17.30	15.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.82	0.72	-4.22	3	70	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	48	0	0	58	2297	42.00	67	46.41	CHANGED	pPVSSWKALSLsKTLSMASSARLKPLNCSRoPCVaAQETKpL	..RPVSSWKALSLRKTLLMASSVRLKPLNCSRLPCVaA.EThph.	0	0	0	0
+3357	PF04478	Mid2		Mid2 like cell wall stress sensor	Kerrison ND	anon	DOMO:DM04295;	Family	This family represents a region near the C terminus of Mid2, which contains a transmembrane region. The remainder of the protein sequence is serine-rich and of low complexity, and is therefore impossible to align accurately. Mid2 is thought to act as a mechanosensor of cell wall stress.  The C-terminal cytoplasmic region of Mid2 is known to interact with Rom2, a guanine nucleotide exchange factor (GEF) for Rho1, which is part of the cell wall integrity signalling pathway []1.	23.10	23.10	23.10	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.05	0.71	-4.81	6	122	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	88	0	81	123	0	108.60	28	28.33	CHANGED	sos.ssTI.TSlIcGpTILSstYTTlTYTPouTu..usss+ptpp.GLSKKN+NIVIGCVVGIGVPLllllLsLlYhFCIpssRTDFIsSDGKVlTAY+sN+hoKWWhsLLGKcl..o-cYpS-SPlGu.ssshps.tltpscDlhpsspshohctsss-up	..................................ss.....sh..o.oh...p.G..p..Th....h.s.sth..o...T...l....Th...o.sosos..........ss.s.sp.s...pso...G....L....Spps+.sIl.IGlVVG.lGs..sll.l.s.hlsll.ahhh..........................................................................................th........................................	0	14	46	75
+3358	PF01187	MIF		Macrophage migration inhibitory factor (MIF)	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.10	0.71	-4.00	6	669	2012-10-01 20:38:22	2003-04-07 12:59:11	13	13	403	152	326	668	118	108.50	27	78.19	CHANGED	PhhplcTNlPpspVPsuL.p+LostlApuhGKPtphluVclsPGttMsaGGSo-PCAlhSlpSIGsV.uucpN+SaoptlhchLscELplspDRlhIpFaDlpuuslGaNGoThu	...........................Phh.lpTN..l..s..h...s..p.h.s...p...s..lh..............p.c.h.sptl.uph.......h....GK....Pcsalh....lt.lp...sshshh..F...u..G.o.p.-.P.sAhs.pl..p..Sl.G.s..l...ssppN....cphottlsp.h.lppcLu..ls.t.s.R.halpahshpst..hGaNGssh....................................	0	106	186	263
+3359	PF03775	MinC_C	MinC;	Septum formation inhibitor MinC, C-terminal domain	Bateman A, Finn RD	anon	COG0850	Domain	In Escherichia coli Swiss:P06138 assembles into a Z ring at midcell while assembly at polar sites is prevented by the min system. MinC Swiss:P18196 a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with MinDE. MinC is an oligomer, probably a dimer [1]. The C terminal half of MinC is the most conserved and interacts with MinD.  The N terminal half is thought interact with FtsZ.	29.70	29.70	30.10	30.20	29.30	29.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.20	0.72	-4.40	15	2118	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	2070	4	484	1401	159	105.10	38	45.31	CHANGED	ThllcpsVRSGQpIYuc.GDLlllGsVssGAEllA-GNIHVYGsLRGRAhAGspGss.sApIaspplpuELluIuupahhs-c....lssphhscsspltlcs-tlhlpsL	.........hllcpsVRSGQplaut...uDLllhusVssGAElIA.cGNIHVYGhlRG.RA.lAGss......Gsp..pApIhsppL.pAE.LluIAGhYhh.u-p.......lssp.....h.h.s..p..s..s.p...l.h.L.p..p.s.t.lhlp..h...........................................	0	152	303	397
+3360	PF05209	MinC_N		Septum formation inhibitor MinC, N-terminal domain	Finn RD	anon	COG0850	Domain	In Escherichia coli Swiss:P06138 assembles into a Z ring at midcell while assembly at polar sites is prevented by the min system. MinC Swiss:P18196 a component of this system, is an inhibitor of FtsZ assembly that is positioned within the cell by interaction with MinDE. MinC is an oligomer, probably a dimer [1]. The C terminal half of MinC is the most conserved and interacts with MinD.  The N terminal half is thought to interact with FtsZ.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.14	0.72	-4.24	8	1242	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	1231	5	255	716	30	102.50	34	43.57	CHANGED	hppssl.-LKuophslslLpLcss...slsclhptLucKIspuPsFFpcsPlllslucl....-slshpALcpshpppGlpslGl.....thtppc...l..hph.G.LslLocucsp	.........................hppssl.ELKGSo.FTLoVl+..L+cs...-..cs.lcptLp-...Kl.u...QAP.u...F.h.c.pAPVVls.lu..sL.........cs...s..l..s..a.sslpp...s...l...s...ssGL+llGVss....tstphcsp......h....tch...G.LPlLstupt.....................................	0	66	134	198
+3361	PF03776	MinE		Septum formation topological specificity factor MinE	Bateman A	anon	COG0851	Family	The E. coli minicell locus was shown to code for three gene products (MinC, MinD, and MinE) whose coordinate action is required for proper placement of the division septum. The minE gene codes for a topological specificity factor that, in wild-type cells, prevents the division inhibitor from acting at internal division sites while permitting it to block septation at polar sites [1].	25.00	25.00	29.00	25.50	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.37	0.72	-4.47	104	1852	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	1808	14	433	931	152	69.60	41	75.76	CHANGED	SAslAKERLQlllAH-Rsthps...-....hLspL+cEIlpVIsKYVpl-p.-plplpl-.+s.psh......ssL-lNIslsc	......oAslAKERL.....QlIlA.c-Rsssts....sc.....YLspL+c-ILcVIsK..YV....p.IDs...-tlpVp.l-.+s....scl........olLElNlsLPc...................	0	129	267	356
+3362	PF00230	MIP		Major intrinsic protein	Finn RD, Delamarche C	anon	Prosite	Family	MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.68	0.70	-4.89	14	9641	2009-01-15 18:05:59	2003-04-07 12:59:11	15	26	3806	68	2727	7120	1558	211.20	28	85.40	CHANGED	Ehpphsh..hRAslAEFluThlFlFhuhG..ouluhsttst.........................s...........sllslAlAaGhulhshV.ssup..ISGuHlNPAVThuhhlupplollRAlhYhlAQhLGAlsusulL+hhpsu....................pssthss.lusGhssspuhshEllhTFhLVhslaussDch+ssp.up....APLuIGhhVshstLsuhPhTGsuMNPARSFGPAllttp..............assHWlaWlGPhlGAhluullY	................................................................................h..........tt.hhuEhlGT.....h..lh..l...hh.GsG........ssh....h...th.t..h.s..................................t.........................shh.hls..h........u.a..G.....h.u.....lh.....h..h..l.a....s...sut.....l...S...G..u..Hl..N.....P...A..........VTl................uh.......h........l.......t.........u.............p...........h.........s............h.............t......c...s......h.......Y......l...l...A...Q.hl.GAh.....h.....u.......u.s.l.l.h.h.hh.h..s.h...............................................................t.t..hs..h...h.....s....p..h....s..s......s......t......h....s...h..h..p....u......hh........s.Eh..lhT...hh...Ll.h.s...l.....h.........u.......h........s........s.....p....t............p..s.....s.....s.....................................h..s.s.l..s.....l...........G...h.h..l....hh...l....t.....h....s.....h.......s....s....hT......G......h.u.h.NPAR.s...h...G...P.t.lh.t..t.h........................................th..t......h.W.....l.....h...l.uP.l..l....G.u.hluuhha.....................................................	0	763	1487	2164
+3363	PF03094	Mlo		Mlo family	Mifsud W	anon	Pfam-B_2483 (release 6.4)	Family	A family of plant integral membrane proteins, first discovered in barley. Mutants lacking wild-type Mlo proteins show broad spectrum resistance to the powdery mildew fungus, and dysregulated cell death control, with spontaneous cell death in response to developmental or abiotic stimuli. Thus wild-type Mlo proteins are thought to be inhibitors of cell death whose deficiency lowers the threshold required to trigger the cascade of events that result in plant cell death. Mlo proteins are localised in the plasma membrane and possess seven transmembrane regions; thus the Mlo family is the only major higher plant family to possess 7 transmembrane domains. It has been suggested that Mlo proteins function as G-protein coupled receptors in plants [1]; however the molecular and biological functions of Mlo proteins remain to be fully determined.	18.50	18.50	18.50	18.50	18.10	18.30	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.66	0.70	-6.38	10	512	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	76	0	283	513	6	337.20	33	80.51	CHANGED	sstpoL-pTPTWAVAsVCsVllhISlllE+hLH+lG+ahK+++KKALaEALEKlKsELMLLGFISLLLTluQsh.IucICl.spclupsMhPCs........s.tcEcsshupph...........ssR+LLt..............shAssusspCucKG+VPLlShpuLHQLHIFIFVLAVFHVlYsllThsLG+hKI+sWK+WEcEstsh..-a-husDspRFRasH.......-TSFlRcHh.shWo+.oshhhWVtCFFRQFasSVsKoDYLTLRpGFIssHhss..ss+FNF+KYIpRSLEDDFKsVVGIS.hLWshsVLFLLlNlsGWcoYFWloFIPLlllLsVGTKLEtIIocLALEIpE++sVlcGsPVVpPSD-hFWFu+PcllLaLIHFlLFQNAFpIAaFFWIhasFGl+SCaHcphshllsRLllGVhlQlLCSYhTLPLYALVTQMGSpMK+ulF-EpsucAL+sW++ssKc+pchtt.......ppGusssssucssss......spuoSssplLppspspsss	............................................t.........sW.ls.hh.hhl.hshhh-h.lphhtp...........hh.pp.pp.p.h.tsl....+hpt.......ELMllGhlSLlLsh.hpt..l..plCl.s...t.h.......h.h.C.....................................................................................................................................C.......t......G......sh.hS.tulcpLH..hFlFhLAlh....HlhashhT..hhLuhh+.....h.pt.W+.WEtph.t............p.......................t........h.....h.p................p....pFhpt+h......t..h.p........hh........ah....hsFh+QFh.tSV.+sDYhshR.uFl.h......Hh...........pasFppYhhRuhEp-FchlV..Gl.........S........l..Whh.slh...hh...........hhs..hp.G.h............hhW.hsh......lPhhll.LhlGsKLphllhphu...........c..............ht...t.......t...t.....hh...........p............t...............hl....ps........pcphFWFt+PphlLhL.IphhLF..................Q.NuFphshFhW.h........h..p..hu..h...p....oChht.p..h...........h........h.+lh.hG.hhhQhlCSY.TLPLYAlVo.QMG.ophK..tlht.pphtpslhtWttt.s..+pp..t..............................................................tt.......................................................	1	53	194	244
+3364	PF03304	Mlp	Lipoprotein_12; 	Mlp lipoprotein family	Mifsud W, Bateman A	anon	Pfam-B_1663 (release 6.5)	Family	The Mlp (for Multicopy Lipoprotein) family of lipoproteins is found in Borrelia species [1]. This family were previously known as 2.9 lipoprotein genes [2]. These surface expressed genes may represent new candidate vaccinogens for Lyme disease [1]. Members of this family generally are downstream of four ORFs called A,B,C and D that are involved in hemolytic activity. 	21.00	21.00	21.40	21.00	20.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.21	0.71	-4.21	13	220	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	33	0	23	188	4	128.90	36	65.43	CHANGED	sQQTKSRpKRDLoQcEhsQQ.K.p.p..EEhLhppLs..................cspKo........ahDWLp........Ehhsuhuch.cFLEsc...cuKhKoh.saIKutlDspsup...............spsNcttsshpsslppaF+GsshDhF....uNptlhpCh	..................................pQsKSRtKRDLo...QcE........sQp.K.p.p..EEhlhppLs.......................cspKs..................ahDWL+............-hlsuhsch.pFLcpc..........cuKhKshhsaIKutlDpsss....................ppssp.tss.h.pp.lpthh.pGs..h.D.F....sspt..t................................................................................	0	9	9	9
+3365	PF03562	MltA		MltA specific insert domain	Bateman A	anon	Pfam-B_1127 (release 7.0)	Domain	This beta barrel domain is found inserted in the MltA a murein degrading transglycosylase enzyme [1]. This domain may be involved in peptidoglycan binding.	25.00	25.00	28.10	27.70	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.85	0.71	-4.50	47	1797	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	1393	13	305	1164	129	152.30	46	39.97	CHANGED	llcuStspsspapaPlYphPssh....................................................................tp.thhsa.sRtpIp......tsult.puhpluascs.lDhFhlplQGSGplphsD....Gphlp.luYAupNGaPYpuIG+h..............Ll-cG..................clstcphShpuI+pWhptp.Pp.clpclLppNsSaVFF+	...............................................VlpuccpRpupapaPlYthPsc..........................................................................t.tht.h.o.Rsp.I.........uG.A..L.s...cu.hlLuYups.lDsFhMclQGSGhlch..s..D....G..p..h..l..p.huYAuKNGHsYpSIG+h..............LlD+G...................l...c....tp....p...hSMQu..I+pWhcp..p....Pp.cl....pE....LLppNPSaVFF+................................	0	69	167	238
+3366	PF01642	MM_CoA_mutase		Methylmalonyl-CoA mutase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1611 (release 4.1)	Family	The enzyme methylmalonyl-CoA mutase is a member of a class of enzymes that uses coenzyme B12 (adenosylcobalamin) as a cofactor. The enzyme induces the formation of an adenosyl radical from the cofactor. This radical then initiates a free-radical rearrangement of its substrate, succinyl-CoA, to methylmalonyl-CoA [1].	19.00	19.00	19.20	19.00	18.00	18.90	hmmbuild  -o /dev/null HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.56	0.70	-6.36	11	3025	2009-01-15 18:05:59	2003-04-07 12:59:11	17	11	1507	35	1053	2608	2315	449.20	38	72.72	CHANGED	apTsEGIslcPlYt..ccchp-hpt..htshPGhhPFsRGsYsTMYshpPWTIRQYAGFuTsc-oNthY+hslAsGQpGLSVAFDLATppGYDSDsPRlhG-VGpAGVAIDol.DMchLFcGIsLsphS....VSMThNGsllPlLuhYlssuEcQGVp.ppLsGTlQNDILKEahsRsTYIaPPcPShRlIuDIhtasuccMP+aNoISISGYHhpEAGAoAs.ElAaTLADGlpYl+sulsuGLslDsFAPRLSFFauIGhNaFMEIAKhRAARhLWA+llcp.Fu..sKssKShhLRsHuQTSGWSLTtQDPaNNllRTslEAhAAslGGTQSLHTNuFDEAL..uLP...T-FSARIARNTQlllpEEStls+VlDPhGGSYYlEpLTcclsccAhphIpcI-EhG................GMs+AlcsGlsphcIpEuAA+cQscIDpGcpslVGVNKYpl.cEttl-..lL..cl-sssVctcQlc+LpchRusRDsctlctAL-tlscsAt......tst...NLLsLulcAuRspsTlGEho-Ahccsasca	.....................................................................................................................................................pt..ht.ha..........t..t.........t....t...h.....................h.sh..sG..PahRG..sh...s..s.h.h..h....sp...sW...s.....hRQaAGauoA.c.-.oN.tha..+.h.t..l.s..t..G...p.p.....G..L......S..s......A.FD..h.sTh.hG.hD.sD.p.s.p...l....h....G...-V....G.t...s.GV...ul.s.ol....DMc..hLFc....sI.sL..s..p..h..o....lS..M..Th.N...u.s...sh...s....l..l.A.hal.ss....u.........c..-..Q...............G.............s..s................................p......................p......................lpG..Tl..Q..s..D..I..LK................E....ahs+...sT.aI.a.....P.P..p..s......S.h..+.l..l.....u..D.lh.t.a.s.u.p.p..h..P..+a...s..o..ISI.SGYHhpEAGAssspElAaTLAsGhpYlcshl........p..t....G....l....s..l....D....p....F...A...s....+L..S.F..F.auhuhs.h.FhplAKh.RAARhLWuclhct.as.............sps......s.+..............u.h....h..LR.....hH..sQTSGhoLTtQ-PhsNllRoslpAhuAsh...G...s...spSLH.T.Nu.hDEA.l........u.LP.......o-hSsRIAhsTQllltpE.otlsc..shDPhuGSaalEpLTppltcpAhthhpcl-p.h...G.................................GhstAl...csGh.phpIp-uutcpptpl-p..Gc....p....sllGVN.ca...................t...p.....-.....p.........h....-...............l.l...........pl..-.........s.............s.....h............p......t..p.......Q..l.....t..........pLp..p.h..+.....t.....p...R.....c.....p.....t.....t.............sp.............t...sLt....tl....p..ps....At.................................tt........Nlh.thhhpAs+s..h.solGEhstshptshst..................................................................................	0	382	755	937
+3367	PF03972	MmgE_PrpD		MmgE/PrpD family	Bateman A	anon	COG2079	Family	This family includes 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle.	28.20	28.20	28.70	28.80	26.30	28.10	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.25	0.70	-6.31	16	2262	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	1523	6	768	1930	3171	437.30	28	94.04	CHANGED	ppshcclAcaltshphosh....psh-ps+htllDslGsuhsuhpp.sspthhs.hs.sshsps.ssplhsTptphssstAAhsNGshs+hLDasDsahuAchttsSsslPulLAsA-tluts...........h..c-lLpAhlhuYEItsplAtptuhpchs...hspshalslAuAAusucllsL-p-plhpAluhAhspusulRphcputhsup+t..usu.AstsGlhuAhhAtpGhsG..Psslh-sphGFhcshhss.shphp.................atlpsshhK..aPsphHupoAs-AAhpL+cchp.....hpcIcplplcTapsAh+llscss.......sPpshcsscaSl.YhlAlsLlhGphslppacsch.hpDscl.sLtc+lphp.sscasptY....Pppps....splhhccsssht-ttl-hPhGc.hcpshuhsplh-KFcplhtthhs..pppp.hhhttshcptpltshhss	...............................................................t...h.plsc.al.hshp.hss.h......shcpA+htllDsl..Gsul..t.u.h...p..h..s.......s.s.p.phhs....h......s................u.....t.....s.......s......s..............s.......u............sp.V....G..........s..........s...........h.....p.l.....sP..s...tAAas.Gshh+hLD.......a......sD.T..........a.h....u...A...c........ht.t..su.........s..........sls......u....lLA..sA.-h.l.ups...................h...+clLpAhltuaE..lpsp..l.....u.........h....t.........s......u..hs..+hs.............hs.p....s.h..h.s...p.....l.....u.....usA.ssuch......LG......Ls..p-p......l.hsAluh....A..h.s..p...u...t...u.....L......+...p...h...p...c..us....s.sup+t..hssGpAsppulph.......Ahh.A.p.p.G...h.G.....P..s..slh.t...s.t......h...G....Fh.cs...h.h...p...s...p...s.h.cht...pshu...................................pas.h....p..s..l..h.a..Kh.aP........upaaupsAl-AA.h...pL..tpp..httt............ss-I.cclsl...c......T...pc..s.sh.cl...l..s....c.ts............s.ssst.-..t.ca.sltYhlA..lsL.l...h...G.c...l..s..h...........s.c.apc...........sh...h.....p...c....s........clps.LtpKlps.h.p.D...s..p..hots.Y..........Ppc.psh................ltl.th.p....c..G.s.....p.h...p..hhlch..s.hG....p...hccs......uhsplh.pKFpt.ths...th.hs....ptp...hhh....t.....................................................................................	0	185	425	615
+3368	PF02406	MmoB_DmpM		MmoB/DmpM family 	Bashton M, Bateman A	anon	Pfam-B_1148 (release 5.2)	Domain	This family consists of monooxygenase components such as MmoB methane monooxygenase (EC:1.14.13.25) regulatory protein B. When MmoB is present at low concentration it converts methane monooxygenase from an oxidase to a hydroxylase and stabilises intermediates required for the activation of dioxygen [1]. Also found in this family is DmpM or Phenol hydroxylase (EC:1.14.13.7) protein component P2, this protein lacks redox co-factors and is required for optimal turnover of Phenol hydroxylase [3].	25.00	25.00	25.90	43.80	24.10	19.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.48	0.72	-4.00	40	224	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	168	27	81	207	3	87.60	31	82.55	CHANGED	sspVslslp..ss--scsllEAlttD......NPs..stVp-psuhl+IcucGcLplc+polpEtL.GRsaclp.-lplslsohuG+lpps.D-phslpa	..............stVslslp..ss-pucsllEultp-......NPs...ssVpcpsuhl+I-up.ucLhlctpslpEtL.G+s...achp.plclshsohsG+lspp.DDphhlh...........	0	29	57	73
+3369	PF03176	MMPL		MMPL family	Mifsud W	anon	Pfam-B_357 (release 6.5)	Family	Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.92	0.70	-5.73	34	10072	2012-10-02 18:57:54	2003-04-07 12:59:11	10	47	2346	0	3112	23929	8914	311.20	16	68.96	CHANGED	shsspsusuhtshcphsphF.p..ssssshhhlhh.tsstsLss.sspsshpphlsplppDsstlspl.D.......................hs.......................ss.....stthhhSsDG+Ashh.lshpGs.usstu.pslsslcshscpss...s.pGhpshlsGsAuhhtDhpcusstshtllthsslsllhllLlllaRSllssllhlhTVslSlssuhGl.lhlhtthhslslsshslsl.hshlhlAsGoDYslhLluRa+EthttG.cptt....uhhpAhtuoGpVlsuuGLslAhshhu...LshucLshhsp.lGsslulGlllssLsshTlh.PAlhsl...........hGRh...............s.t....................thW..phuthls+tPtsh	............................................................................................................................................................................................................................................................................................t.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..s.............-.......t.....p.....h....h.............h..h..........l...........h............p...............t..............t......s.......t.....t.......s........p.......t.......h..........p.........t....l.....p....p.....h...h.p.ph...........................ts.h.....p..s...h...l....s....G.........s..s...h...t.....t....-......h..t...p.........t...h...p.......p.......s...h..h....h.h......h......h..l...s...l.s.l......l...h....l...l....L..h......l..s......a.....R....S......l....h.....s.......s.....l....l....s....l......l...s.....s.........h......l....u.....l.........h..........s.........s........h.........Gl.......h.....h.........h..........h............t.........h.........h.............h..........h...........h...............s...............l..........s.........s..........h.........s...................s.........l......s........h....s......l....h..l....u....l.....u....h......D..Y..sl......a....l.....l.....s........R....h.........+...E.......p..............h.....t........p..........s.......t..........s......t..........p........................A....l...h.....p......u....h....t......s......s....G......p....s....l....h........h...u........u....l....s...h....s....s.u....h...h..u...............h......h.......h............s...............s...........h.........s......h.......l..............p...p......hG..h...........s.h...u....l.......u.l....l....h....s..h....h....s.s..h.s....ll...P....A....l..h.t..l..................................h..uph...............................................................................................................................................hh...........................................................................................................................	2	1002	2163	2770
+3370	PF01926	MMR_HSR1		50S ribosome-binding GTPase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.14	0.71	-4.13	703	46032	2012-10-05 12:31:08	2003-04-07 12:59:11	18	181	5181	76	12638	71407	21684	130.90	24	37.52	CHANGED	plullGhPNsGKSoLlN..tL...............s..............t...t.....p..........hsh..................................lush..s...us..Tpch.hh.......thh.h..........................................tt.................h....h.llDosG..................................lh............pt...tp.h.........................t.........hhpt........h..hptl.pps...........-l...llh.......ll.......D.sp................h.......t................t...pl......................h.....................ppl............................................................tt.shlllhNK	.....................................................................lullG..h.PNVGKST..LlN..tl..........................................s.......................s....p.c..............hsh............................................................................................................................................s..u.....s..h.......s.......t..s....T...pc.......h..................th..h.ph.................................................................................................................................ss.t.p....................h...........h.llD..T..s....G.............................................................lh................cstt.ps.t...................................t....hhp..p........................h....hp....t...l....pps.................................cl...........llh........................ll.....-...hpp...............t.............................tt.....l.....h.....t.h...........................................ths.h.hhhhsK..........................................................................................................................................................................................................................................................	0	4467	8137	10741
+3371	PF01054	MMTV_SAg		Mouse mammary tumour virus superantigen	Finn RD, Bateman A	anon	Pfam-B_518 (release 3.0)	Family	The mouse mammary tumour virus (MMTV) is a milk-transmitted type B retrovirus.  The  superantigen (SAg) is encoded by the long  terminal repeat. The SAgs are also called PR73.	21.60	21.60	27.40	27.40	21.40	19.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-11.90	0.70	-5.53	5	88	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	18	0	0	93	0	231.20	73	95.85	CHANGED	MPRLQQKWLNSRECPTLRGEAAKGLFPTKDDPSAHTRMSPSDKDILILCCKLGIALLCLGLLGEVAVRARRALTLDSFNSSSVQDYNLNNSENSTFLLGQGPQPTSSYKPHRlCPSEIEIRMLAKNYIFTNKTNPIGRLLITMLRNESLPFSTIFTQIQRLEMGIENRKRRSTSVEEQVQGLRASGLEVKRGKRSALVKIGDRWWQPGTYRGPYIYRPTDAPLPYTGRYDLNFDRWVTVNGYKVLYRSLPFRERLARARPPWCVLTQEEKDDMKQQVHDYIYLGTGls.lWt.hFaYT+EGAlA+lLEshKAssh	................................................................GLFPTpDDPSAppRMSPSDKDIhILCCKLGIALLCLGLLGEVAVRARRALTlDShN.sSSVQDYNLNsSENSTFLLtQGPQPTSSYKPHRhsPSEIEIRMLAKNYIFTNcTNPIGRLLlhMLRNESLsFSTIFTQIQ+LEMGIENRKRRS.TuVcEQVQtL.AoGLEVKcGK+SshVKIGDRWWQP..GTYR...GPYIYRPTDAPLPYTGRYDLNFDRWVTVNGYKVLYRSLPFRERLARARPPWCVLoQEEKDDMKQQVHDYIYLGTGM..ahthFa.o+EtAht+ll-phpt...............................	0	0	0	0
+3372	PF05067	Mn_catalase		Manganese containing catalase	Bateman A	anon	COG3546	Family	Catalases are important antioxidant metalloenzymes that catalyse disproportionation of hydrogen peroxide, forming dioxygen and water. Two families of catalases are known, one having a heme cofactor, and this family that is a structurally distinct family containing non-heme manganese [2].	20.80	20.80	20.80	20.80	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.71	0.70	-5.65	6	1280	2012-10-01 21:25:29	2003-04-07 12:59:11	7	5	890	24	300	1030	18	231.50	36	96.59	CHANGED	MF.hHsKcLQY.sKPs+PDPshAKtLQElLGGpFGElSsAhpYLaQGaNpRscsKh+...DLLhDluTEEluHVEMlATMIu+Ll-sAssctpEcAsc.s.hhtulhuGhNspH..uIloGhGuhstsSsGsPWoAsYIluSGNLlADhRtNlsAEupuRlphtRLa-MTDDPGl+DMLoFLlsR-thHQ.pahtAlcpLctp-.s.hlPss........as+thEcQEhu+phhNhScG-.sopupWhpGcu.-thtthphlhtshshuthPcL...............+sAP.h.+sT.......lsspthh	.........................Ma.hap.K.c.L..p.a..s.V.+.l.spPsPthA..phL.EQhG.GspGELuAAhpYhsQu.hsh..p...s.t...t..t......+...-lLhD...IuTEEluHlEhluohlthL..hcs..u...ss.p........h.........c....s....s.......t............................................................................................sp...H...........hl.......tutush.ssusGsP...WoAsYlp..s..pG-.huDLhpNlAAEt+A+hhYppLhph.o.DD.ssl+-sLpFLhsREhsHpppFtcALpplpsph...............................................................................................................................................................................................ttt.........................................................................................	1	112	214	248
+3373	PF03962	Mnd1		Mnd1 family	Wood V, Bateman A	anon	Wood V	Family	This family of proteins includes  MND1 from S. cerevisiae. The mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair [1].	29.90	29.90	29.90	30.10	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.63	36	274	2012-10-04 14:01:12	2003-04-07 12:59:11	10	2	237	0	195	289	2	181.60	31	82.42	CHANGED	lhchFhpopshasLK-LEKhsPK.p.GIsshpVK-llQsLlD.-slVpsEKIGouNaYWsFPupshp..........................ptcsphpcLppclpchcpchpplppplppt.ctsRcps.............p-Rpp.lhpclppLpcchcpLpsclp..phppsDPptlcch+ppsphhtpusspWTDNIas..lpsahpp..phshpppplc...pphuIs.p-h-Y	..........................................hhphFhpopshapLK-LEKhsPK.p.GIs.u.hsVK-llQuLVD...D...shVcsEKIGooNaYWuFPucthp....................................................................tpcpphcpLppplpchppchtpLppplppt.....ct....sR.p-o................cERpp..hhpclppLcp...chppLc...s-lp.......phpc..s......D.P.p.hlcphcp.thpht+cuss+W.TDNIas..l.pp..ahpp..p..h.shppptlc...cthtls.t-hc.................................................	0	82	114	162
+3374	PF04039	MnhB		Domain related to MnhB subunit of Na+/H+ antiporter	Kerrison ND, Finn RD	anon	COG2111	Family	Possible subunit of Na+/H+ antiporter [1], [2]. Predicted integral membrane protein, usually four transmembrane regions in this domain.  Often found in bacterial NADH dehydrogenase subunit.	21.80	21.80	22.10	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.69	0.71	-4.06	25	1811	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	1346	0	552	1386	262	127.40	30	27.60	CHANGED	shIlcsss+hlsshllhauhhlhltG..H.sPGGGF.uGlhhAsuhlLhhluhuhp....phhphphttlhslG..lhhshlssls.hhhGhshhs.......h.hshhu...........pshlhsshhhslGlhlssstsshhhh	...............hllpsss+llhsllllhuhalhhpG..HssPGGGFluGLlhusA...hlLhhlA.h.shc..h............h...............pp........h...h.................h......s...............ht.h.lh.ulG.......ll..h......ush.o...ul.s.u.hh...h.G..t....s.FLop.............hhhplPhlu....................phcl.soshhFDlGVhlsVlGsshhh...................................................................................	0	158	340	458
+3375	PF01899	MNHE	DUF68; 	Na+/H+ ion antiporter subunit	Enright A, Ouzounis C, Bateman A, Cerutti L	anon	Enright A	Family	Subunit of a Na+/H+ Prokaryotic antiporter complex ([1],[2]).	21.80	21.80	21.80	21.90	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.97	0.71	-4.59	164	1796	2009-09-11 05:06:25	2003-04-07 12:59:11	11	2	1345	0	544	1267	256	146.80	25	89.96	CHANGED	hslhLhllWlhLs........s...........sp.........llhGhllullls.hhh.....pt.h.h...h.....................h........tllth..lhhh.lh-llhuslpVAthl.Lp.spht....p.Puhlplslclcsch.slslLAshIoLTPGTlsl-l...........sp-p.....ph..LhlHslc......hsst.tt....hhppl..ppphEchlh............cl.a	..........................slhlhhhWlhls.........s...p.hs..hss.........hlhGh.llulhlh....hhh.......pt.h.hst..p................................hhhphh.....thlph.lh.hhlh-l....lpuslp.Vsph.l.......lp..sphp...hc..P......u.hlt.h...h.c.lc.s-h.slslL.ushI.TLTPGTlslcl.................................sp..-..p.....ph.lhlHsl-...hsst...cp............htpl...ppphEchlhcl.......................................	0	161	337	456
+3376	PF03404	Mo-co_dimer		Mo-co oxidoreductase dimerisation domain	Bateman A	anon	Bateman A	Domain	This domain is found in molybdopterin cofactor (Mo-co) oxidoreductases.  It is involved in dimer formation, and has an Ig-fold structure [1].	20.90	20.90	20.90	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.91	0.71	-4.52	25	2673	2012-10-03 16:25:20	2003-04-07 12:59:11	11	47	1355	31	742	2393	488	104.90	33	28.91	CHANGED	cauIh-Lsl..NSsIspPpHsEhlslss.......tsYsl+GYAYuGGGR+IsRVEVoLDcGcoWpLAslcatEc..+.....tc.............tpaCWsaWsL-lsls-...Lhssc-IhlRAhD-uhslQPc..chhWslhGMMNNsWaRVsIphp	............................................phsh..pShls.P.t..t..t.p..l..hs.....................t.hplpGh....Aa..sGs..u..t.lt+V-...lo...hD....t....Gt.sWp.u...p...l..t.....t.............................................asWphW..php..l...p.l.s...................ust.....c...l..hsRAhDcshssQPc....p.hWNhh......s.............t........................................................	0	208	443	625
+3378	PF01967	MoaC		MoaC family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.	20.70	20.70	24.50	24.30	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.79	0.71	-4.50	19	3524	2009-01-15 18:05:59	2003-04-07 12:59:11	16	27	3330	47	977	2349	1242	135.10	51	71.35	CHANGED	MVDlopKssopRpAhApuhlphpscslchIppsplt..KGDVlusApIAGIhAAK+Tu-LIPLCHP.LsLouVcV-........hchp.ct..lclpusV+spG+TGVEMEALTuVSVAsLTlYDMsKAl-+s.......hhIpsl+LlEKoGG	...........................MVDVSsKstThRpAhApuhlph.p.s.c.s.l.p.h..I.........t...s............u.....p...hp...................KG.DVlusARIAGIhAAK+Ts-LIP.L.CHP.LhLopV-Vs...................................hp..h..p....s....p...p.......t....lcIpups..+ss..G.+.T..GVEMEALTAsSV................AALTIYDMsKA.V....-..Ks.................MhIssl+LlpKoGG.....................	0	325	623	829
+3379	PF02391	MoaE	MoeA; MoeE;	MoaE protein	Bashton M, Bateman A	anon	Pfam-B_1056 (release 5.2)	Family	This family contains the MoaE protein that is involved in biosynthesis of molybdopterin [1]. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.	21.40	21.40	21.70	21.50	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.42	0.71	-4.29	18	3376	2009-09-10 22:57:28	2003-04-07 12:59:11	12	13	3008	21	906	2269	1201	115.20	35	72.11	CHANGED	cltlsspP..lsssthhphlsssps..GAIVsFsGhVR-hstG+.pVppLpYEuYs.MAtcpLppIspEsc.........p+asshc.ltlhHRlGhLplGEssllluVuusHRp-AacAscahlDplKpcl	........................................................t...lt.ps..hs..h..s.p.....h.p.h..l..t..p...ppp......G.A.llsF....sG..pV.R..s.t.........s............t.....G............c......pl...ps......L......p.....h..E.t.Ys.s.M..s..c+t..LtcI..sp-sp............................p..+...W..s...l.tp....lsl.hH.RlG.pLtsG-thVhluVoosHRpsA.FcAspalhDhlKsp.s.............................	0	273	561	756
+3380	PF01076	Mob_Pre		Plasmid recombination enzyme	Finn RD, Bateman A	anon	Pfam-B_717 (release 3.0)	Family	With some plasmids, recombination can occur in a site specific  manner that is independent of RecA.  In such cases, the  recombination event requires another protein called Pre. Pre is a plasmid recombination enzyme.  This protein is  also known as Mob (conjugative mobilisation).	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.25	0.71	-4.67	18	1003	2012-10-02 18:54:05	2003-04-07 12:59:11	14	11	568	0	72	798	47	164.00	24	46.75	CHANGED	Mu.aulhRhpKhK.ssslsGhppHspRpppsp...pNcDIDh-+othNh-Lhss.pshsappcIcphlpcph.tp.RtlRpDAVlhsEhllTuss-Fa.csho.E-p+caF-puhcahpccYGc.pNllhAslHhDEs...........TPHMHhG.......lVPhs-ct.....+LSAKclhst+cpLpphQs....chschhpppGapLcRGptt...oc+KHhssspYKp	......................................................................h...Khp........tsht.ht.H....pR.....pp.............sl..pctt.N...hc.h..h.....p............t.....p......h..p............p..t..l.p.phlpp....h.....................pth+.pcs.h.hh..........chll.o...s..s..c....hh.......p........t..........h........s..................p..c..............t.........cpah....p...p........shp...hh....p.c...+..h.....Gp..pNlh.AslHhDEp....................TPHhHhs.......................hVPh..spst.........................+ls.u+plhs......c......p.....p......Lt......thps...................ph.phht..p....h..lp.R.G.......ott..cp...h..ah............................................................................................	0	20	46	62
+3381	PF03389	MobA_MobL		MobA/MobL family	Mifsud W	anon	Pfam-B_3424 (release 6.6)	Family	This family includes of the MobA protein from the E. coli plasmid RSF1010, and the MobL protein from the Thiobacillus ferrooxidans plasmid PTF1. These sequences are mobilisation proteins, which are essential for specific plasmid transfer.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.53	0.70	-4.93	9	1275	2012-10-02 18:54:05	2003-04-07 12:59:11	10	14	701	1	159	1186	123	200.30	31	35.78	CHANGED	RSAssuAAYppss+h..E+ps+shDYsp+p.lhapEhlL.PspuPp.h....sDR......pshWNcVEshE+RssupLs+-lplALPhELTs-pphtLlc-FlcchhsscGMlADhslHt.........................Dss.tNPHsHlMhThR.lstDGhhtpK.....hhlstsGp.h...........hsttGc.......lhhp.W.sspshhsphRcsWt-phNptLpttGlshRIDtRSacpQGI-hhPTlHlGssu+thE++	..................................................................SslusuAY..huspplhs........-....h...u...........hh..c.as..p+p....lhh.pphhL..Pt..p...sP..t...h................t-R..........................ppL..WNt.....V.....E..t.h...E...+.........p....psu..pl..ARch.lAL.P..p..E..L.......s.pp.p...........hpLlpcaspc.p...h..s..s..p..GMhsDh.AlHp........................................................sss....t....NP..........HsHlhhohRs...l..s....cGh.h.ttc.............h..tptst.....................................................................ttt.............................psW....sspp...thp.taRcpWushsNphLtpt.s..h.......pt.....R.........lDcRSh.......pp.Q..............u.......h....c........PphH.G.tsttht......................................................................................................................	0	30	90	120
+3382	PF03205	MobB		Molybdopterin guanine dinucleotide synthesis protein B	Mifsud W	anon	Pfam-B_2446 (release 6.5)	Family	This protein contains a P-loop.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.92	0.71	-4.47	28	2671	2012-10-05 12:31:08	2003-04-07 12:59:11	9	40	2297	9	887	3759	1045	131.50	27	46.35	CHANGED	shlhlVGspDoGKoTLhctLlshhhppGh+sshhhchch.Gp.slshPGs..............luhs.hcc...h.h.pth..ppphs...............llhh.Gaps.sspsc...lslsp...phsphhppph..........................pt.shllso	...........llsls.G..h.s.soGKTTLlcpL.l...s..t......L.......p.........t...c.........G....h.....+....l...u...h....l..KH.sc.H......p.....h...-...........l..D...h.......s..Gp....Do..h....ch...tpA.G...A...t.t..s.l.l.s..upp...............ht.h..h....p.p.....h..............p...p...p.s.....L..t....lhtths..................hD..llLl..E..GaKp.t...shsK.....l.lh.R......t...........................................hhh.hhh.t..............................................................................................................	0	285	523	732
+3383	PF04698	Rab_eff_C	MOBP; MOBP_C-Myrip;	Rab effector MyRIP/melanophilin C-terminus	Waterfield DO, Finn RD, Eberhardt R	anon	Pfam-B_4174 (release 7.5)	Domain	This domain is found at the C-terminus of the Rab effector proteins MyRIP and melanophilin.	20.80	20.80	22.10	20.80	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	714	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-13.27	0.70	-6.42	7	193	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	47	0	70	165	0	315.90	37	56.40	CHANGED	ChDlltGuhhEsslENEGSIsGSDSTFYRQSE.GHSMMDTLAVALRVAEEAlEEAISKAEuau.DSLDKQNEAsYLR-HKEELhEELATTIlQKIIRKQKsKoEQt..Et-s-WPpsp....ssSspsuDpuhhshPGucRusssLWRSQSAFSlsuEDs......htoussEuhh+p.+spsp+.+-c..SALPSWKSVDpLs-oshsPVLpSsDGNWVALpsso.hPPs..RhLAKPKSpsFpALEstSpVsSAYDEhGS-SEEDaDWu.ALscLp.pspth......tps..pst.s.us-ph..ssSPSsuh.sNsEshh.SDSETSShsSSpEu+.tpu+..WlpR+sspN.sptEKh+lpGEL..DVNFNPQusuhEhSDSSEsEEs.ash-++uRRW+Rs+stsEE.s.t.spscuph+sLpTpps.t...DLSETDlSsEspcp+o.sDshEEKL+oRLaELAhKMS-KETSSGE-QESEsRTEs-NQKpuLSSE-supsVQEELKKKYSAVSLCNISTEVLKVINATEELIAESoGPW-hPssstD+tcGoFPlGTD.lRLDEQLToLEENVYLsAGTVYGLEGQLoELEDAARpIpSsTsEoELA-LEDQVATAAAQVHHAELQISDIESRISALTlAGLNlAPCV+LTR+R-QKQpsQVQTIDTSRQQRRKLPAPPV..KuEchEuSsVTslKTFNRNFlLQGShTpRsK.ERKSosKDLMEPsltSAlMY	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................st.Ts-pELu-LEDpVAssAupVppuE.plSDIESRIuALphAGLslts..sc.p+..+pp....................................................................................................................................................................................................................	1	2	8	33
+3384	PF05161	MOFRL		MOFRL family	Bateman A	anon	Guo J	Family	MOFRL(multi-organism fragment with rich Leucine) family exists in bacteria and eukaryotes. The function of this domain is not clear, although it  exists in some putative enzymes such as reductases and kinases.	20.20	20.20	20.20	21.40	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.38	0.72	-3.92	14	869	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	746	3	399	837	348	107.80	45	25.09	CHANGED	PssLlsGGETTVslpG..p.G+GGRNpEhsLuhshtlc....st.sh...hhLuusTDGIDG....soDAAGullsssshtp.hpstGlD..tphLpssDSYshapthus...LlhTG.TGTNVND	..............................PsslLuGGETTVT.l..p..G................p....G.......+GGRNpEhh..LuhA....hslp.......................Gh.s...s.l...........hsLuusTDGlDG.........spDsAGAh.ssssols+...hp..t...tG...........l....c.....stshLssNDuashFpsl.us............Llh.T.GPTtTNVND................................	0	127	238	325
+3385	PF04603	Mog1		Ran-interacting Mog1 protein	Waterfield DI, Finn RD	anon	Pfam-B_4771 (release 7.5)	Domain	Segregation of nuclear and cytoplasmic processes facilitates regulation of many eukaryotic cellular functions such as gene expression and cell cycle progression. Trafficking through the nuclear pore requires a number of highly conserved soluble factors that escort macromolecular substrates into and out of the nucleus. The Mog1 protein has been shown to interact with RanGTP which stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran. The human homologue of Mog1 is thought to be alternatively spliced [1,2,3,4].  	19.80	19.80	20.80	21.90	18.00	19.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.86	0.71	-4.24	3	266	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	230	2	185	261	3	130.10	31	62.57	CHANGED	ssPLFGGALSAILPPthlDVS-LRpIPDNQEVFsHsSTDQ.SlIVELLEhQE+VpDuuAARYHFEDVAusNDAcu.scVhSVcPLuL-sL.uLRu-CssAWlLoGpQpV...AKcNpEuAssVsIHhALlRLPQaQTDLLlTFNsPs	.................................p.h.LaGGAls.s.slPt....sahDlS....sl.RpVPDsQEVFs............s...s............s...........s.............c...........p...S..........lIlEl...................LEhh......s...................p.......s..........ps..t....p..A....hpaahpD...lu.t.p...s......s..ts..........hpl.....p....t................h..............t.p.h............t.............................................t................s........h..h.h...u.tp..p.h......................s+....t...p...p...........t..p......l.hl.hh..s..llR.L..p.....hpT.......Dlllohs.P.h........................................................................................................................................	2	59	103	150
+3386	PF04879	Molybdop_Fe4S4		Molybdopterin oxidoreductase Fe4S4 domain	Bateman A	anon	Bateman A	Domain	This domain is found in formate dehydrogenase H for which the structure is known. The first domain (residues 1 to 60, 448 to 476, and 499 to 540), comprising two small antiparallel sheets and four helices, coordinates the Fe4S4 cluster just below the protein surface [1].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.96	0.72	-4.15	65	10650	2009-01-15 18:05:59	2003-04-07 12:59:11	11	141	2936	51	2519	7754	1735	56.60	28	7.53	CHANGED	hchsposCs.aCGsGCulplts.......pssclh............plpustppPsNp.....GplCsKGttshph.lts	................phshosCs..hC..u.....s..G..Cu.lphts.................cssc..lh.........................pl..cu...c..s...s....s..s....s..sp............................GthCsKG.tthhchl....................................	0	756	1595	2106
+3387	PF00384	Molybdopterin	molybdopterin; 	Molybdopterin oxidoreductase	Finn RD, Griffiths-Jones SR, Bateman A	anon	Prosite & Pfam-B_2803 (Release 7.5)	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.38	0.70	-5.74	32	25621	2009-09-12 07:55:41	2003-04-07 12:59:11	17	170	4023	138	4565	20492	6386	349.30	16	53.56	CHANGED	RLppPhlR.....................................p.pGcahtloWc-ALshlsptlpp..tphsp....h...sssushsssEshhshpchhpthsut.hth.sthsch.............sss.ptshhhssslt...............sl-suDh..llLhGsNstpptsll......ss+hhpthhpst.....hclsslusphs......hshshcaluh..ssso.hsl.hshtpshhpphpt..sc.....................................................................................................................................................................................................................pshlllGt..Ghhpp.....tcGsshhttltslsthhs.ht....sasshs........................................................................................hlpstAspsush....................................................clsh.ss.thh...t..t....phhalhG...........................sDtsph..t......ph....chhllhpsph.spsAphADllLPussasE....+puhasNsEGpsQt....tppsl.ssG-A+pDWcIl+sLuch	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................Rlt.Ph..hp.....................................................t....s...t....h....h.sWppAhp.h......ttt......h.........t..........................................t...............................s...................t........h..................................h............................h.........................................t............h............h...t...................h......h..t.....h..h.h......t................................h........t........s..p..........t.............................................................s..........................................p.h....t.....p.s..ph.....h.....hhh.G....t.......N......h..t...s..t..............................h..h..h.......t.hh.tt............................hphlsl.s...s.hhpt............................ht....t.s.........a....h..........p.s.s.Dh.sh...h........u..h......h............h.h..........h..........p..........p.................h.................st..........................................................................h.........t.............h...................h...........................................................................................................................................................................................................................................................ht.......t..t..h...........t........h........t....h....s........t............h....................t...........................t...............................................h.........h.........s.h..............u..pp..............................u.........................h......h...h....h.......hG..p...h........s..........G...s.......s.....................................................................................................................................................................h....t.......t.............h..h..............................h..............................................................................................................................................................t..........................................................h.......h..............................................................................h..t...h...........h......h.h.t.................................................................s...............t.............p....t.h.h........t.h.t.........ph........c...h.h...l.s....-........h.......h...s......t............s.............s..................h............u........D...............l..........l............L.P.s.s.....hE...................p..........t.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1319	2784	3767
+3388	PF01568	Molydop_binding		Molydopterin dinucleotide binding domain	Bashton M, Bateman A	anon	Pfam-B_129 (release 4.0)	Domain	This domain is found in various molybdopterin - containing  oxidoreductases and tungsten formylmethanofuran dehydrogenase  subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase  subunit (FmdD); where the domain constitutes almost the entire subunit. The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a  molybdopterin dinucleotide cofactor [1]. This domain corresponds to the C-terminal domain IV in dimethyl sulfoxide (DMSO)reductase which interacts with the 2-amino pyrimidone ring of both  molybdopterin guanine dinucleotide molecules [2].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.25	0.72	-4.24	87	16734	2012-10-02 17:45:13	2003-04-07 12:59:11	16	106	3319	124	3570	12374	2211	112.40	22	13.29	CHANGED	lhL.hosR.shtphpoth.tstps.thtphts......hl.lsPpDApphG.lpcGDhVclpoppG....phhstA..tlocp.lt.Gslhhshtaht.................sssNhLT..ssthcPhuttPth.+ss.s	.......................................h.l.hos.+..ht.p.h..H..oth..t......s.hp.h..h.p.h.tp.hts.................hlhls.....Pp..DApp..h..G.........lp.....s...........G...D...h....V.............cl....h.....s.......p..p.....G...............pl..t..s.tA........hl..o.p......c.....l........h........s............G........s........l........h........h.....hshhh...................................tsthNsLT...t.thsshsthst.p...............................................................................	0	995	2156	2944
+3390	PF04744	Monooxygenase_B		Monooxygenase subunit B protein	Waterfield DI, Finn RD	anon	Pfam-B_6020 (release 7.5)	Family	Family of membrane associated monooxygenases (EC 1.13.12.-) which utilise O(2) to oxidise their substrate.  Family members include both ammonia and methane monooxygenases involved in the oxidation of their respective substrates.  These enzymes are multi-subunit  complexes.  This family represents the B subunit of the enzyme; the A subunit is thought to contain the active site. [1,2]. 	22.70	22.70	23.10	24.50	19.20	22.60	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.30	0.70	-5.76	5	143	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	76	12	16	144	19	231.40	40	82.99	CHANGED	GEKSQpAFLRMRTIpWYDlKWSK-olKVNEossIoGKFHVFEsWPcAVupPcsSFLNVGpPGPVFVRLooaINGphsPRSlsLEIG+DY-FEVsLKARRPGcWHVHTMlNVcGGGPIIGPGpWIsITGSMuDFcNPVTLLTGpTVDLETaNhuNsIFWHlhWhulGlAWIGYWstRPMFLPRhhhlpAGcDD-LlsspDKKVuhlVLluTLLlVlhGY+sTEoKaPhTIPLQAGppKslpPLPVcsNs......VSlKVpcANY+VPGRALRlTlcVTN+GDpPl+lGEFTTAGlRFlNusVhKc.DssYP-ELLAscGLShDssuPIAPGET+sV-lcApDAtWEVQRLuDLlYDPDSRFGGLLMFaDsoGNRplssIuGPVIPsFs	...............................................................................Gtcs.tsh.Rhpoh.aaD.h.at.............p.htls-.hshoGKhhlhtsWPp.slshPthuFhNhu.PuPshhRhtphlst....p..h..Shsl.hGts..YpaclplKARhPGpaHlHshlNVcsuGPllGPGtalslsGshssFpsslphLsGpTl.shEsashsphhhW..................................................................................................................................................................................................................................................................................................	0	7	12	15
+3391	PF03473	MOSC		MOSC domain	Aravind L, Anantharaman V	anon	Aravind L, Anantharaman V	Domain	The MOSC (MOCO sulfurase C-terminal) domain is a  superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.44	0.71	-4.68	30	4691	2009-01-15 18:05:59	2003-04-07 12:59:11	12	41	2815	8	1479	3587	1209	130.30	22	44.61	CHANGED	pGhss-.........sshphptus.............cpslhlhspcslstlpppls.pt...............ssstFttNlsl.....sGhs................Esphh....cphplGs..shlcVspspp.Chhhshch.........psuph............................hthhhtshh.GhhhpllpsGplpsGDslpl	..............................................t...............th.hphus...............spsl..h..lhsp...ps...h...t...t.....h..pp..c.h.s...tp....................................................shstF..t.tNlsl........................s.G..h.s.................................................Essh.h.............cth...+.l.....Gc..................sll..pVs....p.s..pp...Ch.th.sh.p.h.............ppsph.............................................................................................................................................h..t.h...h...h.s.......h......G..h.h..h....p.....l..l...p..s...G...h....l.psGDtlp...................................................	0	425	840	1217
+3392	PF02722	MOSP_C		Major Outer Sheath Protein C-terminal region	Bashton m, Bateman A	anon	Pfam-B_653 (release 5.5)	Family	This is a family of spirochete major outer sheath protein C-terminal  regions. These proteins are present on the bacterial cell surface.  In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and  fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola [1].	25.00	25.00	25.00	26.90	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.45	0.71	-4.76	8	373	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	20	0	10	327	0	169.80	53	36.12	CHANGED	DALL........ohQW+WlSsGsYhATAsuNVFGpplhspshosahDsAuFl+lETK.uGDPhT+LlsGLsuGV-sRlYIPhTatlYhsssu....t................th.sspIsLPVsGKsWsSY+IsLu-auWlKPasslYGsTNRhshss.u...........pphppthshtYcVGlohSPlEKVElcspWEQGpLucsPYhs........Ipcslos...cpa.GTFVCGlKlsW	...................DALLThtYRWhSuGuYFAotuoNVFtsshL.s.p..s.h.s.p.h.DhAAalKLETK..uuDP.TphLpGLDhGV-sRsYhPlpathhh......................................................ssssIphPVhGKsWsSYRhshG-YGWVKsYAslYGuTN+tsss.s.sus..................pphptEYCuhYcsGlshSPhEKh.h..h.............................................................................	0	10	10	10
+3393	PF02707	MOSP_N	MOSP; 	Major Outer Sheath Protein N-terminal region	Bashton m, Bateman A	anon	Pfam-B_653 (release 5.5)	Family	This is a family of spirochete major outer sheath protein N-terminal regions. These proteins are present on the bacterial cell surface.  In T. denticola the major outer sheath protein (Msp) binds immobilised laminin and  fibronectin supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola [1].	25.00	25.00	36.30	35.50	18.20	20.10	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.22	0.71	-4.74	7	405	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	20	0	10	364	0	167.70	49	36.84	CHANGED	laAElplKsLpVshpostsu..........t..as.spppsolEATLHCYGAYhTlGpsPsFhsNFApLWcPalsss.Ycpc..cspYAPGFsGhGGKlGY+ApsluuSGlslDluhLSFuSNGsW-utsos...................HSKYGFGuDhsLsYshtt....pchlplElAuNATLpptYppuspp.ssst..ppsplLWslGuRlTLpPhssF+hshAhDsGs	..............................spl.htsh.hth......................ht.ht.thp.hpATLHhYGAYhTlGpsPshhssFA.LWcPahspt.Yppc..ts.YtPGFtG.GG.KLGY+tpDIuGoGlohDIuF.pFASNssW-upsss.s..s..u.s.................................................................HSKYGhGuDlhhuatRsR....QEhl+VELsGNuTLu..sGYspu..sts..........s.......phstlLWsVGu+lohp.hhGhph.hA.........................................	0	10	10	10
+3394	PF01618	MotA_ExbB		MotA/TolQ/ExbB proton channel family	Bateman A	anon	Pfam-B_1099 (release 4.1)	Family	This family groups together integral membrane proteins that appear to be involved translocation of proteins across a membrane. These proteins are probably proton channels.  MotA is an essential component of the flageller motor that uses a proton gradient to generate rotational motion in the flageller [1]. ExbB is part of the TonB-dependent transduction complex.  The TonB complex uses the proton gradient across the inner bacterial membrane to transport large molecules across the outer bacterial membrane.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.57	0.71	-4.55	28	9835	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	2969	0	2514	6816	4219	133.80	23	52.20	CHANGED	hcthsshtth.thhshpphhthths.....htptthhctlphthppsh.sp.ttpLppshslLuTluusAPalGLlGTVhGIhpsFhslutsup...sshsslusGIupALlATAhGLhVAIPul.lhYNhlsppspthhtchcthtp	.......................................................................t........................................tt.h....h....c..t..l.p.t...t.h.c...p.th....pp....tt.p....ph..pp..shsh...L.uslu.u.hu...Ph....lGLhGTVhGl...hpu...hts......l...u...t............tt............ss...h.s.......h....l.......us.......GIupALl....uTshG.lh..sA.l.s.ul..hhashlpp.pspphht.hp....t.................................................	1	796	1613	2101
+3395	PF04006	Mpp10		Mpp10 protein	Wood V, Bateman A	anon	Pfam-B_12513 (release 7.3)	Family	This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites [3].	21.40	21.40	23.30	21.40	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	600	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-13.28	0.70	-6.15	6	429	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	298	0	297	439	2	435.40	22	88.04	CHANGED	plttlpussstFlhspst.usshcslsph.sh.sphp.cstscpsPLsplsh-uhDsEQIWpQLclpsc.lLssl.p.tst..p.hhspccIoshsc.p.p.pp-Dsp-..-.st.ppuDD-p-.c-.Ep......h......s..s.tEsst--.pt..sEss-.pc.-...........-.tt....p...tp.ppKch-spsl-DpFFcL-EhpcaLpptEcc..Ecut.s--cctc-h..D..pchpsD..................Fu.tc.ppsccptslpYcDFFs...............c.hp..pct-.p.pttsscch.cccu-pcp.cpsctD--.-ppps..p..p.......sh.sthc........--.s..tscpsuscphSSaE+cpt+lpp+IcpLEcEsLucKsWpLpGEVsAppRPpNSLLEccL-FD+sA+PsPVITEEsTcoLEDlIKpRIpDpsaDDV.Rps+lsssttch+cphpLscpKSKpSLAElYEpEYh+tsspph........sthspc.sctHpEIpphhssLhhKLDALSsFHFsPKPstsElcIVoNsPAlsMEEVuPlAsSDAthLAPEEIacssKstc...........hocsEhsppDKpRcRRpKKpKpp.................................Kthphstptpphts-tssp.shtps.shhsKht-pssss	............................................................................................................t......................................................................................................la......................................................................................................................................................................................................................t..................................................................................................................................................................................................hpD....tF...hphpphp....t....h...-tt...........t......t.....................t..t.tt...p................c.................................................................................................t...p...t......t..t.........h....h.tDh..ht.......................................................................................................................................t....................t...........t..............t.................................................................................................p....t.......t.......t.....t......t.....t........h...S.s.aE..+pp.c...............h.tpp..I..pplEtt.ltp+.WphpGEsputpRP.NSLL.E....p....s....Lc...F-c.s........s+..................sP.sl..............Tp...E.ho.............p...........lEp........hI+pRIhpp.........taD-.l..+p....................................................t....c.t............h...p.....lsppKup.uLu-lYEp-ah...p.tt....................tpp.p......t+tE..lp..phhppl..cLDuLSshH...ahPKss.......p.h.p.....l..h...s.....s...h.s..s.lshE.-stP.....h...s...h......u....s...s....s......h....lA.PpElht..t.t.t............................hs..ptEhotp..-.+t+.R...pt....tK....p.p..............................................................................t.......t................................................t................................................................	1	106	169	251
+3396	PF05172	Nup35_RRM	MPPN;	Nup53/35/40-type RNA recognition motif	Guo JH, Coggill P	anon	Guo JH	Domain	Members of this family belong to the nucleor pore complex, NPC, the only gateway between the nucleus and the cytoplasm. The NPC consists of several subcomplexes each one of which is made up of multiple copies of several individual Nup, Nic or Sec protein subunits. In yeast, this Nup or nucleoporin subunit is numbered Nup53, Nup40 in Schizo. pombe and in vertebrates as Nup35. This subunit forms part of the inner ring within the membrane and interacts directly with Nup-Ndc1, considered to be an anchor for the NPC in the pore membrane [1]. This region of the Nup is the RNA-recognition region [2].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.46	0.72	-4.26	7	252	2012-10-02 20:46:34	2003-04-07 12:59:11	8	5	191	5	164	260	2	95.70	32	25.66	CHANGED	ssspsusp......VhVFGFP.u.ss.lltcFupaGpIlcch..................................................hspsuNWh+lpYps..pAp+ALpcNGhlhssslhlGV..s..tsKplhstp	..................................................s....scpW.....VTVFG..FP..u.sushlLppFupaG..sI..lcch.....................................................hs.ssuNWh+lpYpSchpAp+ALp+.NGpl.hs..sslh.lGVp.s...h.cphht..p................	0	60	91	135
+3397	PF01188	MR_MLE		Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	C-terminal domain is TIM barrel fold, dehydratase-like domain. Manganese is associated with this domain.	22.40	22.40	22.40	22.50	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.73	0.72	-3.44	1272	5681	2012-10-02 01:07:48	2003-04-07 12:59:11	16	31	2337	582	1586	7550	3093	69.00	28	18.12	CHANGED	tl...pulRcs....hus.th...........t.lhlD.....s...N.........tu..............h..............p.pAlph...hctL.......p.p..........h.....h.alE.pPlss......tsh.......pshtp.l...p....p.ps....lP...l.sss	.............................h.ltsl+ct.....hP..-h........p..ltlD.......sN................tu................W.sh..........ppAhph...sctL..........s.s...................l....talE.-Psss........tph.........cshtp.h....p...........c.ts..........slP..lAs.............................	0	468	964	1332
+3398	PF02746	MR_MLE_N		Mandelate racemase / muconate lactonizing enzyme, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	SCOP reports fold similarity with enolase N-terminal domain.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.34	0.71	-4.10	9	7573	2012-10-02 11:54:41	2003-04-07 12:59:11	11	23	2340	767	2008	5956	2681	111.20	25	29.06	CHANGED	tlpshlsssshs...Ph.huhtohtpt.hVllclp.s-GlsGlGEusshG.......ps.sltshlcsaLuPhLlGpDssplpshhphhh+ushs.....shoAtAAlDhALaDlpu+shshPlscLlG	.........................................................................................hhhh..........................................................t....h.....l......llc..l.p...s...-...s....G.......l.....s.....G...h...GE....s....s...s....hs..............................ts.h...t...s...t...l...p...c...........l..t....s.h......l.....l......G......p.......-....s....t...p....l...p.....p..........l.....h.....p.....t...h....h..p...t..h.hh.......................hshsA..h....uAl...D.......hALWDlh........uK.thsh.Plap.LLG.......................	0	558	1207	1629
+3399	PF04152	Mre11_DNA_bind	Mer11_DNA_bind; 	Mre11 DNA-binding presumed domain 	Wood V, Finn RD	anon	Pfam-B_3909 (release 7.3);	Domain	The Mre11 complex is a multi-subunit nuclease that is composed  of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication [1].  Mre11 has an intrinsic DNA-binding activity that is stimulated  by Rad50 on its own or in combination with Nbs1 [2].	25.00	25.00	27.40	25.20	23.20	24.80	hmmbuild  --amino -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.04	0.71	-4.41	56	403	2009-09-10 20:52:09	2003-04-07 12:59:11	9	9	297	12	239	389	1	164.80	32	24.61	CHANGED	aphpsIPL+TVRPFlhc-llLpcps.........pssscpclp.paLhp............p.V-phIccAppph.................t....tttcss..LPLlRLRV-Yous.................aps.NPpRFup+.FVG+VANss......DllpFa...+.+Kptpp................pptp.tptthht.pphsplclcsLVp-aL....ssppLslLscsshucAVppF	....................aphp.IPLcTVRPFhhc-ll.Lsccs................................psps.pppl..p..p.alhp............t.V-.phI-cAppph...........................................s.p.pps...lPLlRLRV-Yous.................apshNspRFup+..Fls.+VANsp......DllpFh..+++cpppt..............t............tttt.tpt.h....tt.pp.h.sshcVEsL...Vpcah....ps.pLplLspp.shscAlppF..................................................	0	81	132	200
+3400	PF04085	MreC		rod shape-determining protein MreC	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	MreC (murein formation C) is involved in the rod shape  determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.	28.00	28.00	31.50	30.70	27.50	27.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.64	0.71	-4.79	20	3591	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	3553	5	739	2380	2076	151.70	29	50.93	CHANGED	pVlsh.ssssasppllIs..pGppcGl.....pps.sVls....spG.LlGpV..spVsptoS+VhLLoDssp...plslplp..+ss.....................................................hp.GIlsGpsspp........tLplphls..sss-IchGDhlVTSGLG......GhaPsGl.VGpVsplctcsttht..t.htlcPssclpcLcaVhllh.s	..............................................................Vlsp.sss..s.appplsIc..+G..sps..G......l........tps.sVls..........spG.....lVGpV..s.pVsphoS..pVh.Ll.s..c.ssp......tlslplt...+ss........................................................................hp..ullp....G..p...s..s..ps...................Lplppls..........ssscl..p..h..G.......Dh..lV.T.S.G.L....G.........uh..aPpGlsVGpVspV.pp...c.s.tthh.....pplp.lcPsA.shpcl.chlhllh..s..........................	0	258	496	635
+3401	PF04093	MreD		rod shape-determining protein MreD	Finn RD	anon	manual;	Family	MreD (murein formation D) is involved in the rod shape  determination in E. coli, and more generally in cell shape determination of bacteria whether or not they are rod-shaped.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.02	0.71	-4.38	14	2682	2012-10-03 02:46:00	2003-04-07 12:59:11	7	2	2669	0	496	1464	599	156.00	23	93.18	CHANGED	pRhhhtallhls.hllullhth.hsh.ss....hhhhtPpaLhLhLlahslthsppsulhhuhlhGllaDlhhsullGlpshhhsllsallshhhthl+h......hshhhtshl.....l.h...hshllthllths.h.hlh.shap..Pph..lhshlluhlLh.hlhhLhptl	..................................h....h.hll.hl....hl...l.s..hl.lp......h...h......s..h..hs......hhhht.P...pa...l......ll.h...l.l...a.h......s.l.......t.......h...s...c...p...s..s....l......h.hua..lhGllhD.l.h..........h..u..u..........h..........l.G.lpslshsllsall.s.h.h...h....p.h.h..hp...........ls...l..h..h...ts..ll........lhl.......hs.hh...l...t...h..l.....l.h..h..s..p...h...........h.h...h.....l.......s.......h...p.........P.p.h....lhs.h..ll.t.slL.ashlhhhh...h......................................................................	0	156	313	416
+3402	PF03919	mRNA_cap_C		mRNA capping enzyme, C-terminal domain	Finn RD, Bateman A	anon	Sarah Teichmann	Domain	\N	26.50	26.50	27.70	27.30	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.68	0.72	-3.71	11	377	2012-10-03 20:18:02	2003-04-07 12:59:11	10	15	304	18	250	369	89	107.30	30	20.63	CHANGED	phNoVDFhLchsct....t.shL....pphGhlpah...........tt.s.....................+hssp.pphss+IlECpa..-p..psp...WhahRhRsDKopPNshsTscsVlpoIpssVTcEhLlc	..................................................................NolDFplclph....................ps..l.........p.s....hh......ah.......................................................tthp.......h........................t..phpp...p...hs...s+..IlECph...........-p....psp...................Wp.......hh.......RhRsDKspsNphsTsppVhpSIp-sVoc-tLl.......	0	96	147	211
+3403	PF01331	mRNA_cap_enzyme		mRNA capping enzyme, catalytic domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family represents the ATP binding catalytic domain of the mRNA capping enzyme.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.36	0.71	-4.61	12	521	2012-10-02 00:43:09	2003-04-07 12:59:11	14	25	354	18	336	652	333	173.70	27	35.15	CHANGED	pPlShs+.cthchLpppsYhVs.KsDGhRhhhhlsps........sahlDRc.phahlpthpaPhph..........hhphTLLDGEhllDhhtt.....tphRYLlaDhlshsGps.lsppshs..pRhphlp+clhpPpstth..psthhphc..PFtlphKshh.h.tsp+.h..htphhtplsHcsDGLIFpsscsPYssG.pspslLKWK	...................................................................pPVShs....p....pphp..L...pp..sYhVs..K....sDGhRhhhh..lstp...............tsahlD.R...p...ps..hhh.l.p.....hpaPh...........p......................t.h..hp...sTLlDG....E.h..l.h...Dph.s........................ttp.+.....aL.laDhlhh........s...............ups....l...hp...pshp.............pRlthlpcplhp..Pht....ph.....h...............p.....p................h.....hp.........tt.......................p....s.....F...........p......l.ph.Kshh.hh...thpp.......h..............ht.phh...............pl....H..t.sDGLIFp...s..h..p....t...sYh.G...psp.p.....lLKWK.........................................................................................	0	145	207	288
+3404	PF02940	mRNA_triPase		mRNA capping enzyme, beta chain	Griffiths-Jones SR	anon	Structural domain	Domain	The beta chain of mRNA capping enzyme has triphosphatase activity.  The function of the capping enzyme also depends on the guanylyltransferase activity conferred by the alpha chain (see Pfam:PF01331)	20.40	20.40	21.00	21.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.62	0.70	-4.60	24	259	2012-10-01 23:11:28	2003-04-07 12:59:11	10	13	212	14	161	256	64	210.30	23	42.20	CHANGED	.cshs+sls-alht................lpspshpplElEhKlGhlhctp....sspRhphsl.opslhspp.........pspFpsslscspapphpcaLpphs..............................................................t.t..hh.hshhcspppDphYpht...................tp.splRloh...Dsp...sschhtt...IcKcRlssl.lasPpssa..........................................DhRlSlslEhshs.s.......stsssps.thpRpKcRhSYh.+ss..h+hDLT+V..........s..tpscspppaElElEl	...............................................................................h...ltphhh..h..............h..t.....lElEh+hGhlhstp.........ptpRh..th..s...h.........s.tslhppt................thtFpsshs.....tttapthpphLpphs.....................................................................................................................h.hshh.cppppDphaphs......................tctsplRlop....Dtp........ssphhtt....ItKp+ls..slpl.a.Pp.s.s..h.........................................................DhRlSl..slEhshsts..................thtpp..s.t..hpRpKcRhSYp.pts..........hplDlTpV......................t...ttstptphpaElElEl...........................................	0	60	97	142
+3406	PF02349	MSG		Major surface glycoprotein	Bashton M, Bateman A	anon	Pfam-B_864 (release 5.2)	Family	This is a novel repeat in Pneumocystis carinii Major surface glycoprotein (MSG) some members of the alignment have up to nine  repeats of this family, the repeats containing several conserved  cysteines.  The MSG of P. carinii is an important protein in  host-pathogen interactions [2]. Surface glycoprotein A Swiss:O59920 from Pneumocystis carinii is a main target for the host immune system, this protein  is implicated in the attachment of Pneumocystis carinii to the host alveolar epithelial cells, alveolar macrophages,  host surfactant and possibly accounts in part for the hypoxia seen in Pneumocystis carinii pneumonia (PCP) [1].	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-11.10	0.72	-4.01	205	505	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	3	0	0	514	0	90.30	24	46.08	CHANGED	pphht-ppChp.htptC....Lpps.........Cp.php......................Cpp....l+cpC...p.phppctp..................................................hpphhhpph+s.....plpsc....pcCpctL.pc.C.thpp..sp	........................................p....h-ccCtc.htpcChh.Lpps..st..phptp..............CppL+ppCtphthpph.....................................................................hpchLhcthcs......shpsc......pcCpctL.pchCspLpc.tp.t..................	0	0	0	0
+3407	PF04066	MrpF_PhaF		Multiple resistance and pH regulation protein F (MrpF / PhaF)	Kerrison ND, Finn RD	anon	COG2212	Family	Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation.\	      It is also involved in symbiosis in Rhizobium meliloti [1].  MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis.  MrpF is thought to be an efflux system for Na+ and cholate [2]. The Mrp system in Bacilli may also have primary energisation capacities [3].	21.30	21.30	21.30	21.30	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.36	0.72	-3.69	16	1647	2009-09-11 16:03:59	2003-04-07 12:59:11	8	2	1250	0	488	1048	205	54.60	31	57.36	CHANGED	hsDRVlALDslsstllullsllulhhpphhhlDlAlllulLuFluTlAhA+altt	........................sDRllALDslsh.shullslhulh....h.s.s.s.hal-shlllAlluFluTluhu+Fl.........	2	147	300	407
+3408	PF04471	Mrr_cat		Restriction endonuclease	Waterfield DI, Finn RD	anon	COG1715	Family	Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.69	0.71	-4.28	227	2560	2012-10-11 20:44:43	2003-04-07 12:59:11	7	96	1770	1	790	2681	416	113.70	20	32.61	CHANGED	l.p......p...hs.stpFEclltp....lhpp.h..Gap.......s..p......h.st.t.us.Ds...G..lDl...l......h...p.p.s....u......p.............p..h..hlQsK+a.....p........s..p...luh.pt.lpp.h.hu.s.h.p..t......p.p....us......p......GlhlT.o.us...Fo...psA....p...ph.A....p..p.....p....p........lpLl..DupcLhchl	...............................................................h...hss.tFEphltp....lhp.....p...h...Gap...................s.p.............h.st...t..ss...D.t.....G....l...Dh..l................h...pp...s.t....t.......p..................................ph...hlQ.sKca........p..................s..p..........lu.t....tt....l.p..p...h.hu...s.h.t..t................h.t.......ss................p..........................ulhl..T..s.us.....Fo....p...sA....p....ph.A....pp.......p....t..............lhLl..stppLhph............................................................	1	266	525	668
+3409	PF00924	MS_channel	UPF0003;	Mechanosensitive ion channel	Bateman A, Martinac B	anon	Pfam-B_1136 (release 3.0)	Family	Two members of  this protein family: Swiss:Q57634 and Swiss:Q58543 of M. jannaschii have been functionally characterised. Both proteins form mechanosensitive (MS) ion channels upon  reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins.	20.70	20.70	20.70	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-10.89	0.70	-5.00	37	13351	2009-09-13 17:39:23	2003-04-07 12:59:11	13	28	4579	14	3447	9838	4024	200.60	21	41.76	CHANGED	tplhphllhslshlhsLshlGhs...hsullushGhhGluluhuhQshlsslluGlhllh-+.shclGDhlpls...............shpGtVpclslpsTpl+sh-sphlhlPNsplhsppltNaop...pstpRlphslslsasos...hcplhchltchhtppstlhp................................................tshlhhsphussulshplpsasps.......tchhslppplthc.........lppthccpsIph	......................................................t..lhph.h.l.h.h.l.s...l...l..h..h..l.....s..h..l...G.ls........hs..s........l...l........s....s....h....G........s....h.u..l....u....l....G....h....u.h...Q..shlss.hl........uG....l....h.l.l.h.p.c..shclGDh.lp.ls..............................................sh.p..G..s....V..p..cI.....s.l.p.........s.........T.p.........l............p.........s...........h...........D.........s.....p.....h.....l..h.lPNstlh.s.t..s.l..t..Naot....................shtc....h..t..h.s..l...s.l.s......h.....s..s.s...............h.p........p..h.h...p.h........l.....h.....p........h....h...t...p...p....s..t..l.hp...............................................................................p....t..........l..h....h...t...t...h...s...t..s...s...h...s...h...t...lt..h..a..sps..................t.p..h...h.t.....h..ttplhtp.........lhphh.pptslp....................................................................................................................................	1	1007	2127	2858
+3410	PF00985	MSA_2		Merozoite Surface Antigen 2 (MSA-2) family	Finn RD, Bateman A	anon	Pfam-B_1052 (release 3.0)	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.00	0.71	-4.12	5	652	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	19	0	1	531	0	103.60	55	57.25	CHANGED	TTTTTTTNDAEASTSTSSEN.NHpNAETNPKGcGEVQpPNQANKETQNNSNVQQDSQTKSNVPcTQDADTKSPTAQPEQAENSAPTAEQTESPELQSAPENKGTGQHGHMHGSRNNHPQNTSDSQKECTDGNKENCGAATSLLNNSSNIASINKFVVLISATLVLSFAIFI	.........................osoToTTNsuEupToTso..............sA-Ts......spscu.ps.p..Ps.....sspEopssuN..s.pcopsKup..s..pQst.scSspttPc...............APpt.QTtpsE..usP.-N....................................................................................	0	1	1	1
+3411	PF01741	MscL		Large-conductance mechanosensitive channel, MscL	Bateman A	anon	[1]	Domain	\N	22.40	22.40	22.60	22.60	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.71	0.71	-3.99	8	3477	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	3349	6	744	2091	328	128.40	42	92.61	CHANGED	hlKEFKEFAhRGNVVDLAVGVlIGuAFGKIVoSLVsDIIMPllGhLlGulDFu.sluh.h....G...........hsusslsYGlFIQslINFlIIAFAI.FlsIKsIN+L....++KcEs....ps.A.s-....sppsLLTEIRDLLKpp	...........................hlKEFK-Fh.hRGNVlDLAVGV..IIGuAFupIVoSLV...s...DIIMP.l.l.Gh.l..l....G..u..l....D.Fs...sht.h.h.........st...............................h.s...s..s.slpY...GsFIps.l.....lsF....lIl.A....Fsl...F.h..h...l.....K....h....l....N..+...l.................p..+..+...c.c..tt......t...t.s.....s....ss...........pp..LLsEIRDLLcp..............................................	0	218	475	634
+3412	PF01716	MSP		Manganese-stabilising protein / photosystem II polypeptide	Bashton M, Bateman A	anon	Pfam-B_1814 (release 4.1)	Family	This family consists of the 33 KDa photosystem II polypeptide from the oxygen evolving complex (OEC) of plants and cyanobacteria. The protein is also known as the manganese-stabilising protein as it is associated with the manganese complex of the OEC and may provide the ligands for the complex [1].	25.00	25.00	37.30	36.80	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.58	0.70	-5.31	8	265	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	197	17	67	285	155	210.30	51	79.74	CHANGED	-hQsLTY--I+uTGLANpCPsLs-ssRGolsl-uGppYtlscLCLEPosFhVKEEPsNKRQcAEFVssKLlTRhTooLDQIpGclpVsuDGSlTFpEKDGIDFQAlTVQLPGGERVPFLFTIKNLVApTpPshoSlsoShDFcG-FpVPSYRGAsFLDPKGRGluTGYDN..AVALPusuDcE-Ls+pNVKpsshuKGpISLpVuKVDusTGEIAGVFES.QPSDTDLGAKEP+DVKlpGlFYApl-	.....................pshTY.plKGTGhANpCPslssu...ts.sh.slcsGp.YphpchClEPToFtVKt....E.s.hs..K.pt...t....s..-..F.pTKLhT.R.hTYTLDp........lpGshpVssDGslpFp.E.cDG..IDaAslTVQLPGGERVPFLFTlKpLsApupsss...................FuGpF...hVPSYRGusFLDPKGRGssTGYDpA...VA.L.P..A.....t..u....D.....p-....-L.+EN.K..ph..ts..spGplshpls+scspTGElhGlFpS.QPSDTDhGuK..Ph-VKlpGlaYupl...............	0	21	48	60
+3413	PF03429	MSP1b		Major surface protein 1B	Finn RD	anon	Pfam-B_4414 (release 6.6)	Family	The major surface protein (MSP1) of the cattle pathogen Anaplasma is a heterodimer comprised of MSP1a and MSP1b.  This family is the MSP1b chain.  There MSP1 proteins are putative adhesins for bovine erythrocytes. 	25.00	25.00	231.30	62.20	20.90	22.80	hmmbuild  -o /dev/null HMM SEED	726	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.50	0.70	-13.29	0.70	-6.64	5	35	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	4	0	10	61	0	481.30	64	97.78	CHANGED	MTEDDKQQQQNQSNVVQAISAVFQRKSAELQRLNDFIKGADGTLKNVHPHMKSLEALSKQLSEKIAAEAAAKADAKYESVGLRAKAAAALGNLGRLVARGKLKSSDAPKDLDQSIDALPFMDEAPDTGERVVVPAGEEQEFGKAAAWGLAGFKRTVDESLEMLGRGMNMLAEGQAQISQGIADKSTALVREGLETSRLGAGLCRNGLVEASYGVGYANETMGKYAGKGLEKCKNKLGDACYKWSKALEEIENLRTAIDAKAEQQVEGEAWSPEGVSANTFYRGLHKIGAAIAVAAQATWEGLAMTGKFMGAVAKLAGAVSMCVAAYTAAIVGMAAATPATLLLTAMDNQS.VNNAVVKVSEYLHSNVEQATKDLMASEFAMMTFGGIMTCAKLMKGSFAAINQKFEEINATLTREATDIAQGIKETYKSIGDAF..................KSANDGIAKWT.....AALAGYASVEQLEEAKEADRAQAEQRAEAQAMTERVAGERAATVAAGTETIKTIVS..................DMCNELAQIGGLSQAERDALVQSFTPKPPARTTKEIVSQMCNSVKSAFGSISHITNVIRQAGKDAQKIDPQVEVAEISPETIYAMSEALYALNMQESAsINNALLAAVNDSSKDDQAIVTDLINATIEVCTEQTNTLAGHTAEVQAGLEAAGIKLDDAQGLQEATPEA.KGVEGINPEELEQAAEGLATAVNEASADGKIQSLNQQETQIAQGGQHAAQQQSSGWSR	...............................VhQthpAtht+.NthlcthDsh.K.h+.pMpsL-ALpppLppKhA..tEsssKhsthhtSsuLRAKAsA................................M-ps..PsshE.h.s.hGEE.pEFG+AsAaGLsGhK+TlDEulEMLsRGMpMluEGQAplupGltsKsstlV+tGLEhStLGsuhChpuLs-hoaGlthspc.sMGKhAGKGL-KC+pKLtsAs.KW.pAhpEl-sLRTAI.....-t......tAtppsEGEAWSPcGVpuNsFY+uLppIGttIAsAAQATWEGLAMTGKFMGAVAKLAGAVSMCVAAYTAAIlshh...hPAsl.LshMsspS.lsphVs+sucYLHSNVEQATKDLMASEFAMMTFGGIMTCAKLMKsSFAAlNQKFE.ElNATLs.RcuTDIsQGlKEsYpSIGDAF..................KSsNsGIAKWT.....AAlAGYASVEQLEEAKtADRsQA-QpAEtQAMscpVAttRAATVAAGTtTIKTIVS..................DMCNELAQIsuhSQAthsA...........................................................................tEuthlpsALLtAVNDoSKDDQAIVTsLINAsIEVC..TcQTNTLAGHTAEVQttLEAAGl+h-DAp....ss.pt.KGhEGIN.EELtQAA................................................................................................................................................................................	0	0	0	10
+3414	PF04421	Mss4		Mss4 protein	Bateman A, Wood V	anon	Wood V	Domain	\N	21.20	21.20	27.90	21.50	19.50	19.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.38	0.72	-4.15	5	159	2012-10-01 21:11:27	2003-04-07 12:59:11	8	4	136	5	109	153	0	95.40	32	61.01	CHANGED	sscsllNpcc.shV-hPLhsp+pcR.......t...........Dssss-.lc-FaLVKDM.....FsFENVGFS+slc.shKaLVCADCE+GPlGaaDhsscpsa.luLERVsHp	.........................................................................................................h...httt...............t..................sssss-h....lptaWhVp.DM.....asFENlGFo+s.................Vs.....s.....h..............KaLlCADCEhGPIGapsh.s...s+psa.lAhcRV........................	0	38	53	90
+3415	PF03940	MSSP		Male specific sperm protein	Finn RD	anon	DOMO_DM01786	Family	This family of drosophila proteins are typified by the repetitive motif C-G-P.	21.20	21.20	21.50	21.80	19.90	21.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.52	0.72	-10.77	0.72	-4.57	3	8	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	6	0	4	8	1	45.20	74	47.76	CHANGED	CGGPC..CGPCGG..CG....PCG.G.CGPC..CGPCGPC...CGPCGPCGPCCGsscsaCGC	.ssGPCCGPCGG..CGPCGG.CGPCCGGCGPpCGPCGuCGPCCGsspsaCGC........	0	3	3	4
+3416	PF05063	MT-A70		MT-A70 	Finn RD	anon	Pfam-B_3025 (release 7.7)	Family	MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A  methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs. 	21.50	21.50	21.80	21.80	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.38	0.71	-4.71	10	995	2012-10-10 17:06:42	2003-04-07 12:59:11	9	19	544	0	535	970	231	158.10	28	43.04	CHANGED	FslIlhDPPWc.+hhtt.t.....plsYsshsp--lpsLslscLtsc.psllFLWsTspthhps...+psLcpWGachlsc.lsWlKsNphscslt..shpssphhp+spEHCLlGlKGsspp.hst..hptth.....spslIlu...hctpS+KPsElatllE+ls.....stc.+LELFuRs..l+PGWholGsp	......................................................aslIhhDPPWp.........t.............................t..Y.ss....h.....s...........p-.....lt.pL..s...l...p.l..s.....sp....sshlalWss..s..tt..h..ts...........hchl..p....t....W..G.....a....ch.h....sp..hhWlKhs.....p.t..t................p....hh..................................th...........st......h...hp..pspEphLhu.h.+.......Gss.p....t.....t..........................t..................pppllhu................http.....S........+..K............Pst.....hhph..l-phh......................ssht..+lELF.u..Rp.........hpsGWh.shGsp.............................................	1	194	302	434
+3418	PF01993	MTD		methylene-5,6,7,8-tetrahydromethanopterin dehydrogenase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This enzyme family is involved in formation of methane from carbon dioxide EC:1.5.99.9. The enzyme requires coenzyme F420 [1].	25.00	25.00	142.50	142.40	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.46	0.70	-5.36	4	55	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	54	54	41	57	4	271.60	56	99.53	CHANGED	VVKlGlIKCGNIGTS.llDhLLDERADRcDI-VRVVGSGAKMsPEplE...csshchlcEh-PDFlIaluPNPAAPGPpKAREhLutushPAlIIGDAPGL+VKDEhEEQGLGYIllKsDsMIGARREFLDPsEMAlFNADVlKVLAuTGAaRlVQEAIDchI-clKtGK..psELPplVIsppKAVEAtcFoNPYAKAKAMAAapIAEKVADlDV+GCFhppDsE+YIPIVASAHEMhRhAAcLADEARElEKuNDsVhRsPHu.-GKhLSK+pLMtKPE	.VVKIGIlKhGNIGhSsllDLlLDERADRpDIsVRVlGSGAKMsPEplE...cssschlp-h..cPDFlIhISPNsusPGPppARElLtttslPsllIuD.uPuhK.s.K..D..t...hccpGhGYIIlKsDPMIGARREFLDPsEMAhFNuDllKVLAsTGAlRlVQptlDcsIcslctGK...-lcLP+IVlos-KAVEtupFsNPYAKAKAhAAaphAEKVAslDVKGCFMsK-hEcYIPlVASAHEhhRhAAcLsDEARElEKusDuVhRpPHupcGclLsKscLhpKPE....	0	9	28	35
+3419	PF02536	mTERF		mTERF	Bashton M, Bateman A	anon	Pfam-B_1422 (release 5.4)	Family	This family contains one sequence of known function  Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer [1].  The leucine zippers are not implicated in a dimerisation role as in other leucine zippers [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.04	0.70	-5.86	15	1485	2009-01-15 18:05:59	2003-04-07 12:59:11	9	25	144	8	968	1433	16	187.20	13	64.71	CHANGED	LsLh+ShtFosSpISoI......IpsYPplLlscscpoLssKLpaLpS+GASpS-lTclVSsVPcILupcth+olushaDal+cllhs..DpuSphE+hspsLspuspp.sh.pNlulLR-LGlsp+lLhsLLlSchpPVsG+......cph-tplccllEhGhDPsss+hVhuhp..llhphsDKslctpVshh+sLGFslsDVhslhp+tPphLshSpcp...h....................K........t.p.llsoIEphlu..........LGFSR-EhthMV+RaPtslshSsEp.VK+KhEFlVKcMshPl+slVphPpVhuYSLEKRhhPRssll+sLhSKG.......cLsslSpsLssTDppFLp	..........................................................................................................................................................................................h..............................................................................................................................................................................................................................................................................................................................h.............h..h.h...t......h.t..........t.......h........h...........h.................hh..............................................................................................................................h.........tht.hh..p.....................................hG.hs.tppl.h...t...h..lhp.h.P..ll...t.h.............s.cp..lp.php.ah........ht...........h......th.............t.........l....h....t.........P..hh..ht...h..........................................................................................................................................................	0	188	543	757
+3420	PF02219	MTHFR		Methylenetetrahydrofolate reductase	Bateman A, Mian N	anon	Pfam-B_2407 (release 5.2)	Domain	This family includes the 5,10-methylenetetrahydrofolate reductase EC:1.7.99.5 from bacteria and  methylenetetrahydrofolate reductase EC: 1.5.1.20 from eukaryotes. The structure for this domain is known [1] to be a TIM barrel.	19.90	19.90	20.00	19.90	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.62	0.70	-5.32	12	4458	2012-10-01 19:29:00	2003-04-07 12:59:11	12	9	3842	40	1248	3279	1590	271.20	29	75.03	CHANGED	plpphhp..puchhhSaEFFPPKTspG.pNLhsphcRhptht.PhFlsVTaGAuG.....spt.chohslspthppppsl-shhHLTCsshshttlcptLcphhphGlRNILALRGDsPtstc..atp.ptt..hpYAhDLV+hI+p....caGDhFsIuVAuYP..EsHP......psts...hptDlhaLKcKl-AGADFlITQhFa-s-sal+FhspspstGh....shPIlPGIMPIpsacphp+hsphs.pspIPpplhsplp.sl+sD-psl+plGlchth-hspcLlspG...V.slHFYTLNhEcushtIlcpLG	..............................................................................................................t..........tp.slShEhaPP+......s......t....p...h..t......p..pl...h.p.s.l.c.p..Lpt....hp...P..cFl.oVT.auus.u..........................s.p.c.pp.Thphs...p.tlp...p........c...h....ul........p..shsHLT.Ch.s.t.s.t.....p..clpphlts.h.t.p.hG.l.c.pIlA......LRG..D....s.t...s......t...........................s...t....s.....s..............h.p..a.A..s-.L......l...p.h.l+.......................phu..c..............F.......s.......I.u....l...A...u.....Y..P.........Eh.HP....................................cu.p.s......hps..Dl...t..p..L+c.K....l....-....A......G.....A....s.....h.....hI.TQhF.FD.......s....-....p....ah....cF...h...-........c....s....tt.t.Gl.........s.l.P.I...lsG.....I..h...P.l.s.......s.h..p.p.ht..+..h.s..p.hs..ss.c..lP..ph..hhphh-....t................h.........c....s......D....s......p.........s....hc...t.h...G.h..p..h...u...h-...h...h...p...pL......h....p...p.G............l.......shHhY.T.hNpsphshtlhp..................................................................................	0	432	804	1058
+3421	PF05068	MtlR		Mannitol repressor	Bateman A	anon	COG3722	Family	The mannitol operon of Escherichia coli, encoding the mannitol-specific enzyme II of the phosphotransferase system (MtlA) and mannitol phosphate dehydrogenase (MtlD) contains an additional downstream open reading frame which encodes the mannitol repressor (MtlR).	21.50	21.50	21.50	21.90	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.03	0.71	-4.82	4	1088	2009-09-11 14:05:50	2003-04-07 12:59:11	7	2	679	8	70	326	4	169.90	49	95.31	CHANGED	Msshs.......................EsclLE+LNtscolRuFhhTuVslLsEAlctLl.plF.RKD-aAVK.sV-PLLssoGPLsDLoVRLKLlaGLGlIs+plapDIpHhhpl+cpLNcDspEYsFsDs.Ils.IppLsslschuhL...shct.-ssD.SlYphphtRhpphl+SsLoLAlTplhppLsh	....................................................hp...EscVLEpLsAscslpSFhhTAsplLspulphLl.plF.+cD-aAVcY.AVcPLLs..tsG.PLuDloVRLKLIYuLGlls+t.YpDhphhhtl+ctLNc-ss-huFsDDtIls.hup..L.p..sl..s..s.s.........s...t.h.c..ADhulauh..tRapphV+oshsLulTpllpclo.h....................................	0	6	21	46
+3422	PF03083	MtN3_slv		Sugar efflux transporter for intercellular exchange	Bateman A	anon	Pfam-B_623 (release 6.4)	Family	This family includes proteins such as drosophila saliva [1], MtN3 involved in root nodule development [3] and a protein involved in activation and expression of recombination activation genes (RAGs) [2]. Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter [4].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.83	0.72	-4.11	25	2182	2012-10-03 12:15:12	2003-04-07 12:59:11	11	19	651	0	1265	2047	467	83.20	24	68.44	CHANGED	.hlGhlsssholshFhuPLush.tpll+pKSs-shshh.hlsshlsushWhhYGlhhpDh..hlhhsNslGshltsl.llLalhYs.ccp	...........................h.hlGhlushhulh.hahu..s...........l..........sh..hhp..lhp.....s.+...........os.p.t.hs.h.h.....lsshlsshlW...hhYG...l.....h.....p.....p...Dh....hlhhsN.s..h.......Gh.l.huh..lhhhhahha.....t...........................	0	350	759	1105
+3423	PF03821	Mtp		Golgi 4-transmembrane spanning transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.40	22.40	22.60	22.80	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.65	0.70	-4.97	3	234	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	71	0	98	196	0	190.60	37	71.58	CHANGED	HlVMSVLLFIEHoVEVAHGKuSC+h.pMsYLRhADLlSSFLLIssLFIISlSLLIGVVKNREKYLlPFLSLQIMDaLLCLLTLLGSYIELPAYLKLA.RsRsuuSKlPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEDlPHsQFIsMMlIFSVAFITVLIFKVYMFKCVWsCYKaIKsMNSsEEcssSKMhp..KVVLPSYEEALSLPsKTPEG-PAPPPYSE	..................................................................................................................................................hhs..shshh.hslshLhhhhsthhsYGshp..........p......p.suallP.FFChQLFDFsLosLsAhSsls...YlPslpcalsp..........h.Pa+-clhphss.....sLhl...Illlhahhllhh....K..uYhIsCVWsCY+Yl..ps+..N.ss-.........h..s.....sth.t.........phl...L.Ps..Y-.Ah....p..ttp.ssPP.hs.......................................................	1	15	21	45
+3424	PF04208	MtrA		Tetrahydromethanopterin S-methyltransferase, subunit A 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	25.00	25.00	27.10	25.70	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-4.82	6	110	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	65	0	76	111	15	167.80	46	71.55	CHANGED	K+cPAEGWPlVpGDYlVGDPESsVuVVTLGSHlp.csslcAG....AAIuGPCKTENLGIEKVlANlISNPNIRFlllCGuEVpGHITGQohcALHpNGVD.-st.IIGApGAIPYlENlscEAVERFp.pQVElVDLIDlEDh-pIsptl+EClpKDPGAh-E-PhllclpE..GtcEEEEss	...........KKtPAtGWPllpG-Yhl..GsPcSsVAVlTLGS...........Hh.....ps.slc....A....G.......................AAIsGsC+TENLGIEKllANlISNPNIRFlllsGsEVp...GHloGQslhALacNGl...sc...-G...+...IlGApGAIPFlENlsp-ulcRFQ.ppV.EllDlI-sEDhutIpstIc-shuKDP.GAhtt.-shllclpt..tttt......st.......................	0	17	47	62
+3425	PF04211	MtrC		Tetrahydromethanopterin S-methyltransferase, subunit C 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	25.50	25.50	25.60	89.50	23.40	25.40	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.61	0.70	-5.34	4	55	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	53	0	40	55	5	258.60	39	98.46	CHANGED	MSs.uuGGcAtt.....uhP.pplMAlGIlsGLlGhYhush.ss..ltslhuuLuAlsAsVWGADAVRRVAuYGLGTGVPSIGhhuLGhGhlAAlhGlulsus.slPhhAAPIlullluAllGsllGsLsp+lltMKIPIME+shsEISsAGsLulLGhosAlAGSashpuVlshVlAsGhIALlFIlsuMuILHPFNACLGPsEsQcRTLhLAspsGhIshhlA........GLhshsls.....shLlGhlhWhlsFhKFhphoh+DAsuVlaoGhlPKpE	....................huh.usuu.Att.....hhPpsplhslGlluuLlGIYlu..thhss.....lh....shlGGLuAlsAhVhGAsslR+VAuYGLGTGVPSIGMluLGhGlluulhGltlush.......................s....h........s........uP......Il.......ulllAhllGhllGhLus..pslsMKIPlM.puhscLuhAGALulLGhosshu.Guash..s...............sll...............s...............sslssGhIAlhFIhuuhAILHPFNACLGPsEspcRTLtLAltsGhluhllh.......................ulhshshl..........sllluhlhWhlsatpalphohcDAssVhhss.lPct.............	0	9	26	34
+3426	PF04207	MtrD		Tetrahydromethanopterin S-methyltransferase, subunit D 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	25.00	25.00	58.50	58.50	21.90	21.60	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.59	0.70	-4.96	4	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	53	0	40	55	5	213.10	54	91.73	CHANGED	MDhll...lhhhhITlGGllIssuVHFVPVGGAPAAMATATGVGTGTsQLAAGAGLTGLloAAsMs......spshhlIhhuGAVGuMlMlulTMLVGslIYVYGVGsVPsSAKVclDPITthcQ-hYVTPGTEGHGlPTVsFVSGIIGGuLGGIGGuLlYaALhclhhs.u...huss..........VAuIhAlGhFFlNAVlASYNIGGTIEGFHDPKFK+hP+uVVuSLVASI	.................................llslhtIsIGGslIuhuVHFVPVGGAPAAMApuTGlGTGTs.LAAGAGhTGLluAAshst..............................s.shhllhhoGAVGuMlMhulTMllGshIYVaGlGlsPAuuKsphDPITtDpQc.YloPGTpGHGlPTVsFVSGlIGuhLGGlGGuLlYhuLhp.lsh.s.....s...........s...........l..AulhAlGhFFlNAVlASYNIGGTIEGFHDPKF.K.+hPpulluuhlASl..................	0	9	26	34
+3427	PF04206	MtrE		Tetrahydromethanopterin S-methyltransferase, subunit E 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1]. 	20.20	20.20	20.30	131.00	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.92	0.70	-5.38	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	55	0	38	57	5	270.60	54	91.35	CHANGED	LGlLALhGAuATIAGAuEDLESDVGSQSNPNSQVQLAPQMGNlHRaFNKAISGEPVSYuLaCuIAGoVAaVlMpphsLPslhALAlGAuIAAhVHssYAlTAaLGRluS.uupFsQPlYLDMlhSHLGPIAGHGFIsTFCIVulAYLMTllLs...HPFPLPLLAhIWGITIGAIGSSTGDVHYGAEREYQ+YPFGGGlPVAsHGDITRKAEhGlRNuMDsuaFCAKaGGPLTGLAFGLIVFLusWssllhs.....ttGulIs......hhGLlIVhlLIIhN	.....lGslALhGAhATlAGsAEDLESDlGSQSNPNSQVQLAPQMGplHRhFNKAISGEPluYGLasuluGulAasLh.......ths....hs..sllAIslGuslAAhVHGsYusoAalGRhsu.ppcFsQPlYhDllpoHlssIhuHuFIAsFshlshuYLhs...ss..Lu......pPF..PLPLlAlIWGITlGAIGSSTGDVHYGAEREYQph.FGuGlPlAspGsIsphAEhGhRNulDsuaFCuKaGGPlTGlsFGLIVFL-hWRollFs.....thG.u.lls..............hGlllVllhhlhN.............	0	8	24	32
+3428	PF04210	MtrG		Tetrahydromethanopterin S-methyltransferase, subunit G 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of Methanosarcina mazei Go1 is a membrane-associated,  corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1].	21.50	21.50	21.60	58.60	21.40	20.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.32	0.72	-4.30	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	54	0	38	48	10	69.20	41	66.95	CHANGED	--K..lPpslssss-apclpcRLD-IEcKlEFssuElhQ+hGK+lGRDIGILYGlVIGLlL.hIhsllshhF	........s.....lPtslsssp-apcl.c+LDcIEcKVEFssuElhQRhG+KlGRDlGILYGlllGll.lhll.h..h....h.........	0	8	24	32
+3429	PF02007	MtrH		Tetrahydromethanopterin S-methyltransferase MtrH subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The enzyme tetrahydromethanopterin S-methyltransferase EC:2.1.1.86 is composed of eight subunits [1]. The enzyme is a membrane- associated enzyme complex which catalyses an energy-conserving, sodium-ion-translocating step in methanogenesis from hydrogen and carbon dioxide [1]. 	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.68	0.70	-5.42	6	101	2012-10-03 05:58:16	2003-04-07 12:59:11	13	2	81	0	68	133	38	294.50	41	94.20	CHANGED	KEQcVh-IuGVKIGGQPGEhPTVLAGTIFYu+HKIVcDEc+GIFD+-AAEsLIppQE-huDtTGNPhllplhGpTPEAIl+YIDFVA-loD.uPFLIDSopG-lRhAAAcaAoElGLADRsIYNSINsSl--uEI-ALspSDlsAuIVLuFNsMDsoVcG+lplLEsGu.ust-KGhLplA-cCGI.Kh.LIDsAlTPlGsGAGsAl+sohslKuKaGhPlGSGhHNsPSAWDWLRca+KcptEttt.........ssDlGoNllQthAuuDFlLYGPIENA.hlFPAsAMlDhhIuEAs+.-lGlEss	.............................................+cQpVh-luGsKlGGQPGEaPTlLsGoIFYspHcIV...pDtc+GhFD+ptAEsLlscptEhSDhTGNPthlpl..hu..pos.....E....Ahp+Yl-Fls...-ls-.sPFLlDSosu-sRhuusc.h.s.sElGls-RsIYNSINhuhs..c..p..E.l...c...ALp..c..Sclc.uuIlLuF...ss..h..D..s.o.lpG+hplLpsGu.ts.ccGhLplAc.csGIpp...LlDsAlhPlGsGuGh.uh...RushslKu+aG.hP...sGuGhHNssSuW.cWL+ch+Kp.ht.phht................................ssDlGuNllth.htGuDFlLYGPI-NAthsFPAsAhsDhhluEusc.-hGht..h..............................................................	0	20	49	58
+3430	PF05175	MTS		Methyltransferase small domain	Yeats C	anon	Yeats C	Domain	This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other  methyltransferases (eg Swiss:Q53742).	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.93	0.71	-4.88	34	8728	2012-10-10 17:06:42	2003-04-07 12:59:11	9	24	4157	22	1810	48732	14113	160.50	23	53.65	CHANGED	phphpohsGVFStsclDhGoplLlpslst...hsup....llDlGCGhGlluhhhuctsPchp.lshsDhsttAlpuu+tshpsNtlc....sclhhuDlhssht..tcaDhIloNPP.............FHsGt.sht.tlspchltsAtptLpsuGcLhlVuNcpLsYpsh...lcchFG..pschlscsstaplhp	............................................................................t................................................................h.....h...t.........h.................ttp....................lL.DlG...s...G..s.G.........s....l.....u..l....s....l...........A...........p..........t..........t........P............p.............h.............p...........l........s........h.......s...........D......l........s........t......p....A.........l..........p.......h......A.........c.......p....N.....h.............p........p................p.............t.........l.........p..........................l..............p...............h..............h.........p............u.............c.............h..............h...............s..............s.................l..............t....................t............p.............a...........D..........h.......I......l..o......N....P......P................................................h....t......s........up.....p...............s..............t...........h......h........p.......p........l........l....t.......p.......A....h.........p...h.L.p..s.s......G.......L.....h.......l...........h....................................................................................................................................................................................	0	525	1050	1457
+3431	PF02416	MttA_Hcf106		mttA/Hcf106 family	Bateman A	anon	Pfam-B_1826 (release 5.4)	Family	Members of this protein family are involved in a sec independent translocation mechanism. This pathway has been called the DeltapH pathway in chloroplasts [2]. Members of this family in E.coli are involved in export of redox proteins with a "twin arginine" leader motif [1].	20.50	18.00	20.50	18.30	20.40	17.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.51	0.72	-4.85	12	5974	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	3284	1	1554	3673	2404	70.10	27	71.89	CHANGED	luhschllIhlVslllFGsKKLPEluRuLG+oLRtFKpAs+phpst..............................pcpptpc	.......luhhcll.l..l..h.l.l.s.l..L..l.F..G.s....c.K.LP....p....lups....l.G......p.......u...l.......+.......tFK......c....uh.p.-..ptt.....................................pttttttt..t............................................................................................................	0	510	1045	1336
+3432	PF02316	HTH_Tnp_Mu_1	Mu_DNA_bind;	Mu DNA-binding domain	Mian N, Bateman A	anon	Pfam-B_12856 (release 5.2)	Family	This family consists of MuA-transposase and repressor protein CI. These proteins contain homologous DNA-binding domains at their N-termini which compete for the same DNA site within the Mu bacteriophage genome.	21.60	21.60	21.60	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.77	0.71	-4.48	4	448	2012-10-04 14:01:12	2003-04-07 12:59:11	11	15	279	6	72	410	4	108.40	21	26.71	CHANGED	pchsGhPGlPphssGVphhAptpGWpKpp+pGsKG.hAhEYclsSLPpEsRttllt.........uAuhsEhsspo.hhcshsppllhshppLssDppptslchl....l....Phl.stDchhsthGhoppp.tTLhhh.Alssp	......................h.GlsGlPpospGlp....h....t....A+.+.....-.uWt....p........R.....+..R..........pGh.....pG...uhEYplsSLP.psptt.l...h....................................................................................................................................................................................................................................................	0	16	39	58
+3433	PF02914	DDE_2	Mu_transposase;	Bacteriophage Mu transposase	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.30	20.30	20.60	20.50	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.41	0.70	-4.83	2	134	2012-10-03 01:22:09	2003-04-07 12:59:11	10	8	111	3	20	153	2	197.90	45	33.31	CHANGED	VthLpAMpWINGDGY.HNVaVRa.sG-lhRPKTWhWQDV+TRKlLuhRsDhSENhDoIRLShhDVloRYGlPc..HlTIDNTRuAANKhhTGGs.NRYRapVpEs-spGlh.hhGhchHWTSl.hGKGhGQAKPlERAFuhGGLt-YVDKH.hLtGAYsGsNs.tKPD....Nhu-psVDhthFLhsLtpGlt.aNshssR.TEhCuGK.Sas-sFER-aA	..............................pLcAhphlNGDGapasVFV..+..W....s.G..c....l..l..RPKsah...WQDltoRKILuaRsDhSE.Nt-.olR.LuhhDl.......l..pp......Y..G.IPc..+lpIDNsRu.sAsKhhTG.Gs.............NRaR..........F...K.V+...-.-...-spGlh..hl.G.h...c.hHWTo..l....h...hs.cGhGQAKPlERAF.u..hsu..Lt-hlDK.+.PthsGAYTGsss.uKP-.....Nhu.c..+ulsh-hFlts..ltptlthaNs+ssRpoEhCtG..h.SacpsFptpY..............................................	0	8	14	18
+3434	PF03888	MucB_RseB	MucB_ResB; 	MucB/RseB family	Bateman A, Finn RD	anon	COG3026	Family	Members of this family are regulators of the anti-sigma E protein  RseD.	29.00	29.00	29.10	29.30	28.40	28.80	hmmbuild  --amino -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.68	0.70	-5.38	8	1077	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	1056	12	197	621	90	281.60	46	88.58	CHANGED	Lp+MscAsppLSYEloFVhp+suSh-ohRYRH.scp.DG+shA+LlpLDGstpEVlpRDsclSYhpPulpsFTlc.ss.lssshP.lhpsDhc+LSsaYDFlpVG+uRVAGRhssVlRllPKDsaRYuYllalDcEopLsL+SDLLDR-GpLLEQFRslsLsluptlststctLpssshPt...llpsspsstpsshuWpssWLPpGFshhs.thpp.slo-c..l-SthYSDGLFsFSVaVpsscusslpDpps+pGspTlhSchl....GspElTVVG-lPhuTAcRIApSI+Fs	.................................LppMs.ASQsLNYElSF.lp.l.s.c.p.u..lESLRYRH..Ach..D.sc.sl.ApLlphDGPpREVlpRG..s.E.lSYFE..P...G...l-PFT.........ls....Gc..hIsDo....lP...ul..lh...............s..D...............hc.+L...u.....s..aYDF.lsl.G.R.sRlAsRhCpVIRlVs+Du.pR.Y.SYllWhDp-o+LPhRsDLL....DR.DG.E.sLEQ..FRl..lu.hs..V...s.....p.....c...l..u........s....s..h........p....s.L.s........K...s....sL.Ps..................lL...sl..P....s.....u......p..............p....s..c.........h.......s....Wps.sWLPpGFsplupsRR...............s............L........s...s...........h......-s...........h.....lE..SpLYSDGLFSFSV.V...s..t......s..s.......s...s...s...s...-...Q.h..lR.p....GRRT..lhopV+........sss..E..ITl..VGElPPpTAKRIAcsIcF.t......................................................	0	31	91	149
+3435	PF03108	DBD_Tnp_Mut	MuDR;	MuDR family transposase	Bateman A	anon	Pfam-B_271 (release 6.5)	Family	This region is found in plant proteins that are presumed to be the transposases for Mutator transposable elements [1,2]. These transposons contain two ORFs. The molecular function of this region is unknown.	21.80	21.80	21.80	21.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.18	0.72	-4.40	89	954	2012-10-02 23:28:20	2003-04-07 12:59:11	10	78	48	0	424	946	0	64.40	24	8.07	CHANGED	ssthtlGphFpst..pph+pulppaulppphphchh+oc.pp+htscCh....scs...CsW+lhAuptpc.sptapl	.....................hhhGthFssh..cch+pAl...pp.au.lpp.c.hp.ach.h+os..pp.+hps..cCh......tcs.....................Cs..W+l..pApphpt.pphatl....................	0	13	155	219
+3436	PF04310	MukB		MukB N-terminal	Mifsud W	anon	COG3096	Family	This family represents the N-terminal region of MukB, one of a group of bacterial proteins essential for the movement of nucleoids from mid-cell towards the cell quarters (i.e. chromosome partitioning).  The structure of the N-terminal domain consists of an antiparallel six-stranded beta sheet surrounded by one helix on one side and by five helices on the other side [1]. It contains an exposed Walker A loop in an unexpected helix-loop-helix motif (in other proteins, Walker A motifs generally adopt a P loop conformation as part of a strand-loop-helix motif embedded in a conserved topology of alternating helices and (parallel) beta strands)[1].	23.00	23.00	23.10	23.10	22.50	22.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.58	0.70	-5.02	2	745	2012-10-05 12:31:08	2003-04-07 12:59:11	7	2	733	6	73	491	11	224.10	84	15.54	CHANGED	MIERGKapSLThINWNGFFARTFDlDpLVTTLSGGNGAGKSTTMAAFlTALIPD.oLLHFRNTTEAGuopuSRDKGLaGKLpAGsCYuhLDslNSRpQRllhuV+LQQVAGRD+KVDIKPFhIQGLP.pVpPTpllsETls-+pARVh.lNElKDtltthEGspFKpFsSIsDYHu.MF-hGlIs++LRsuSDRSKFYRLIEASLYGGISSAITRSLRDYLLPpNuG	.......MIERGKFRSLTLINWNGFFA.RTFDL..DE...........L..............VT........TLSGGNGAGKSTTMAAFVTALIPDLTLLHFRNTTEAGATS.GSRDKGLHGKL.....KA.G.VCYShLDTINSRHQRVVVGVRLQQVAGRDRKVDIKPFAIQGLPhSVQPTQLlTE.TLNERQARVLsL.NELKDK.LEsMEGVQFKQFNSITDYHSLMFDLGIIARRLRSA.SDRSKFYRLIEASLYGGISSAITRSLR.DYLLPENSG........................	0	7	23	49
+3437	PF04288	MukE		MukE-like family	Mifsud W	anon	COG3095	Family	Bacterial protein involved in chromosome partitioning, MukE	25.00	25.00	26.80	26.60	21.50	17.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.52	0.70	-5.56	3	756	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	742	12	72	290	5	226.30	80	96.59	CHANGED	MPsKLApAIANPLFPALDSLLRSGRHISoD-LDNHAFLMDFQs-L-tFYpRYNVELIRAPEGFFYLRPRSTTLIsRSVLSELDMLVGKVLCYLYLSPERLApEGIFTsQELYDELLTLADEuKLLKLVNNRSSGSDLDRQKLtEKVRoSLsRLRRLGMVhTlG-psSGKFRITESVFRFGADVRuGDDPREAQtRLIRDGEAs..TP-shslEsQtQLhENDTsEtDE.DoEa.GE-E	.........MPVKLAQALANPLFPALDStLRSGRHIGLDELDNHAFLMDFQEaLEEFYARYNVELIRAPEGFFYLRPRSTTLIPRSVLSELDMMVGKILCYLYLSPE.RLANEGIFTQQE.LYDELLTLADEuKLLKLVNNRST.G..S..D..lDRQKLQEKVRo....SLNRLRRLGMVWFMG.pDSSKFRITESVFRFGADVR...uGDDPREAQtR...LIRDGEA..........MslEN.c..LQL.......N..DEoE..E.s.Q...sDS...GEEE..............................................	0	7	22	48
+3438	PF00893	Multi_Drug_Res	DUF7; SMR;	Small Multidrug Resistance protein	Bateman A	anon	Pfam-B_1082 (release 3.0)	Family	This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide ([1] and quaternary ammonium compounds [2], through coupling with proton influx [3].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.02	0.72	-3.52	17	6822	2012-10-02 19:55:49	2003-04-07 12:59:11	14	6	2594	2	1186	4014	2383	92.70	32	83.38	CHANGED	hsal...hLhlAhlhEllusshLK........ocGFo+hhPolhsll...uauluFhhLohuhcp.lPlulAYAlWoGlGhlhsslsullhFtEplshhpllulsLl	................................................................tWl...hLhlAhl.hElh...ushs...L...Kh...........................o.p..G..F..s..+....h...h.....s...s..l...l..s...ls...........sh..sl.S.F...h...h...L..u.h..Ah.+p....l..P..l....G...lAY...AlWs.Gl.Gh...l.ss.slh...uh...l.las-slshhpllulsLl.........................	0	303	684	942
+3439	PF01225	Mur_ligase	FPGS; 	Mur ligase family, catalytic domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188),  MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan.  Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide.  The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine.  The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.62	0.72	-3.91	236	13732	2012-10-10 17:06:42	2003-04-07 12:59:11	20	28	4352	28	3015	10183	5325	86.30	23	18.21	CHANGED	plp.hlulsupshs....shu.hhlshtGhpl...............sGpDhhpp......hhptG.Atshlsc....pst.............................t.th..tspt.tl.l..sttphLuplspthh	.....................lphlslcup..t.hs........shs..la.l.s..h.h.G..t.ps...............sGpD...hhsp........................hhp.pG....ss....shl.sp......cst...........................................................................th...t....s..p..h..s..t.l..V....hs.t.tphLuplst.h.h.............................................................................	1	1033	2013	2574
+3440	PF02875	Mur_ligase_C	FPGS; 	Mur ligase family, glutamate ligase domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Bateman A	Domain	This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188),  MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan.  Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide.  The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine.  The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.13	0.72	-3.95	50	21443	2009-09-14 13:20:23	2003-04-07 12:59:11	16	65	4466	65	4592	15708	6742	85.40	20	18.16	CHANGED	lt.tRh-hlsp..........pshhllsD.YAHsPsuhpsslpshtth...............t+llhlhGsht-...Rstshps.hspltsthssh.lllhs....t.tp.ststh	..........................tRhp..h..l.s.p.............................p.s...s..p.l..lsD..aAHsPsuhps.s.l.puh..p..t.h..s.....................................pt+.ll.hlhG.shhc...................+....s...t.s....h....t.t...h.s.p..h.h.s...t.....ss....llh..h..t..................h.............................................................	0	1552	3028	3916
+3441	PF02873	MurB_C		UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1092 (release 5.2)	Domain	Members of this family are UDP-N-acetylenolpyruvoylglucosamine reductase enzymes EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan.	21.00	21.00	21.30	21.20	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.28	0.72	-4.28	13	4494	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	4271	10	953	3207	1942	113.70	37	35.04	CHANGED	cpplhppspphpppR.h.ppPhchPsu..GShF+NP.sp..............................tAGpLIEcsGL.KGapIGGAp...lSchHANFllNpGsAoucDVlsLIchV+ppVt-caGlhLc.EV+hIG	...........................t..plhpthpclppp+....h...p..P..h....p..h..s..os..GShF.K.NPhsp...........................................................hAGhLI-p.u.GL.KG....h....p.....l.......GG....At.................VSp..+..HAhhllN...t..u......s.......A......Tup........D.......lhsLhctVpppVt-+FGlpLcsEV+hlG..................	0	325	632	810
+3442	PF02976	MutH		DNA mismatch repair enzyme MutH	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.90	21.90	23.00	22.30	20.70	21.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.34	0.72	-4.15	50	953	2012-10-11 20:44:43	2003-04-07 12:59:11	10	5	911	6	127	531	32	101.00	60	39.83	CHANGED	h.LGAsAGS+PcQDF..scLGlELKTIPIstpGc.............PLETTaVslAPLhshsGl.sWcs.SpVpcKLp+VLWlPlpG-RpIPl......u-RpIGsslLWpPss.p..ppphL+pD	.................hLGAoAGSKPEQDF.......AtLGVELKTIP.lcuhG+.....................PLETTFVCV.APL...TGNoGV.TWEo.SHVRHK..Lp..R..VLWlPVEGER...sIPL............AcR...RV...GoPLLWSPsc...E....E-cQLRpD...................................	0	19	53	92
+3443	PF01624	MutS_I	MutS;MutS_N;	MutS domain I	Bashton M, Bateman A, Studholme, DJ	anon	Pfam-B_800 (release 4.1)	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with globular domain I, which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.30	0.71	-4.04	60	5408	2009-09-12 04:05:03	2003-04-07 12:59:11	15	62	4333	49	1586	4546	1040	110.20	40	13.01	CHANGED	TPhhpQYhclKpp.a.DslLhF+hGDFYEhFh-DAhhuu+hLslsLTt+t........tstsp..hPMsGlPh+uhcpYlp+Llp.p.Ga+VAlsEQhEsstts.................+.....s...llcRcVs+llTPGTlh-ss	...................TPhMpQY.hclK....tp.....a.s..........D..slLhaR..h...G....D...FY.E...........hF..........a.....-......D........A.......h......p........A.uplL-IoLTpRs................tsssp....lPMsGlP.a..Hu.......h.-sYlsc..Llp.p..Gh+V.AI..sEQ.h.p-.Ptps......................................K......G......VcRcVscllTPGTlh-t.s...........................................	0	529	978	1330
+3444	PF05188	MutS_II		MutS domain II	Studholme, DJ	anon	Pfam-B_800 (release 4.1)	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF01624, Pfam:PF05192 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein [2].  This domain corresponds to domain II in Thermus aquaticus MutS as characterised in [4], and has similarity resembles RNAse-H-like domains (see Pfam:PF00075).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.77	0.71	-4.11	47	4968	2009-09-11 06:26:47	2003-04-07 12:59:11	12	45	3989	50	1597	4177	853	129.10	23	14.77	CHANGED	shlsu...lht.........cssp.hGluhlDlooGchhlscht.-....hpcLhscltp...lsPpElllspsh.p....................hphh.thphh.....s....ht.hphpp....s..ppplp..pta......sspslcshs........t..thsls.AhusL.....lp......Ylcpsppp.......tlsplp	.................................................NhLsu....lhp................pppt..hGlAhlDl.oo.Gca..h....ls..p..hs.s............hppl.ts-ltp..........lsPpEllh.sc...s.hsp...............................................h..h..p...h...h.....t.......t....h..p.h.h.................t................hp...h..p..h...ps.................s......p..pplp......ppa.....................ts..p..slps.hsh.....................................pt.hthsls...As.usL.....Lp..............Ylcc.TQpp........pls+l...............................................................................................	1	504	952	1325
+3445	PF05192	MutS_III		MutS domain III	Studholme, DJ	anon	Prosite	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF00488, Pfam:PF05188, Pfam:PF01624 and Pfam:PF05190. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS as characterised in [4].   	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  --amino -o /dev/null --hand HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.54	0.71	-4.54	306	6533	2009-09-15 09:54:17	2003-04-07 12:59:11	13	68	4115	50	2168	5633	1219	291.10	24	33.92	CHANGED	ssThpsLElh.......ps................tstpps..........oLhsll.cc.shTshGpRLL+p..a.ltpPLpc.hspIppRhcsVpthh....p............t............t..ppl......pptL....c.pl..s.Dl-Rll....sR.........................l..............................th..........sps.........s...........s+-lht.....ltpul....pth.p.l..............................................................tph.......htt............................................ltphhp..pls................plh.......phlppslsp..p............sh.h.................................................pcG.......t........................hl....tsGhsscLDph+phtppscphltphppc.ppptshsslchthspshsh.....................................................hhpsppsttpphstpahpppshtss.Rahos-Lpchppclhpsppcthth-pplhppLhpp.h.hsp..hstl.ppsspslApLDsLhuhAc	.......................................................................ohpsLElh................psh...................tstpps................oLh..tlL...Dc..otT.s.h.G...............s........RhL......+p.......W..lp.............pPl...h..s...hp.p.I.......pp..R..ps....lp..thh................p...............t...hp........ppl..........................p.p..hL.........................c..pl....h...Dl.ERll..........uR......................................................................l..................................................................sh........................sps.........................s....................................s+DLh.p...........lp.pul..............ptlsp.l..............................................................................................pph.............t.hps......................................................hlpplhp.........pls...s...............htclt.................phl..ppu.lsc....p..................sshhh..................................................................................p-Gs............lI..tsuhstpLDch+phtppspphltphptpccppsulpsl+ltaspshua.........................................................................................................................................................................................................hhphppsttphsstpah++pThtsspRahssELpch-sclhpucpcththEtpl.a.pplhppl.h.....tp......h.....pt.....l...pphup...sl.ApL.DsLhuhA.......................................................................................................................................................................................................................................................................................................................................................................................................................	0	758	1352	1838
+3446	PF05190	MutS_IV		MutS family domain IV	Studholme, DJ	anon	Members of PF01624	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF00488. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds in part with globular domain IV,  which is involved in DNA binding, in Thermus aquaticus MutS as characterised in [4].	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.87	0.72	-3.81	51	5085	2009-01-15 18:05:59	2003-04-07 12:59:11	13	40	4000	48	1596	4267	904	92.30	34	10.61	CHANGED	uasscLDch+phhcpspphltchppct+c..chGl...psLK...lshsphhGYalclocsp....tppl....Pt....pahc..ppT..hKsutR...atTscLpphppclhpscpc	.....................GastcLDchRphtcsu.ppa..l..t...c...lct+ERc.........coGl................poLK.....l..s.a.N...p.....V...a..G..YaI-..l..ocup..............tppl......Pt.......cahR.....+QT...Lp..NuER.................ahT..sELKchEcclLsAcp.t....................................	1	515	946	1314
+3447	PF00488	MutS_V	mutS;MutS_C;	MutS domain V	Finn RD, Studholme, DJ	anon	Prosite	Domain	This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair;  other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and  recombination. Human MSH has been implicated in non-polyposis colorectal  carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of  Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.56	0.70	-4.96	35	9697	2012-10-05 12:31:08	2003-04-07 12:59:11	16	85	4461	50	2841	8224	1959	222.30	35	28.75	CHANGED	YsRPphscp.............slpIctGRHPVVEphh...sttsFlsNDspLspsp........phhlITGPNMuGKSTYlRQsALIslhAQlGSFVPAcpAcIullDpIFTRlGAuDcLspGpSTFMVEMhETAsIL+sATccSLVllDElGRGTSTaDGlulAaAlsEaLt..cch+uhTLFATHY+ELTpLspp.....hss.........Vp..NhHhssh..........Eps.pslsFLapl.ppGsus.cSYGlpVAcLAGl.PpsVlpcA+phLppLEpp	................................................................................spPp.h...s...p..pt..............tl.pl.p..puR..HP..l..l....-p..h......................................h.....l....s.N..s....l.p....l...s...p..p.p...................................phh.l...IT...........G.....P.......Nhu...G.K...S.Ta........hR.................p...............luL..................lslh........A.Q...h.....G..s.a..V.P..A....c............p......u.......p..l.....s.l.h.........D.p..I.F...o....R..l............G..s...........s....D.........s......l....t.......p....G.....tSTF..........h.............sE.......Mp..c........hs............p.I...L........p..........p.........A...............o..........p................p.............S............L...l..L..hDE.......lG........+.GT.soh..DG.h....ul.Ah.A.ll-h.lt................p.......p...h.......p....s....h.s.lh.u.T.HY.h..E..L...s..p.......h...s....p...p......h..t...t.................l.t.....N...h.p.h..p...h...........................................p..s....ppl...h.....a.....h....a...cl......h.......G....s.s.s......c.S..a.....ul.plAp.hh..G..l......Pppllp.....cApphht.....t...........................................................................	0	1046	1858	2452
+3448	PF03023	MVIN		MviN-like protein	Griffiths-Jones SR, Studholme DJ	anon	Pfam-B_1348 (release 6.4)	Family	Deletion of the mviN virulence gene in Salmonella enterica serovar. Typhimurium greatly reduces virulence in a mouse model of typhoid-like disease [1]. Open reading frames encoding homologues of MviN have since been identified in a variety of bacteria [2], including pathogens and non-pathogens and plant-symbionts.  In the nitrogen-fixing symbiont Rhizobium tropici, mviN is required for motility. The MviM protein is predicted to be membrane-associated.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.45	0.70	-6.07	15	3361	2012-10-02 21:24:20	2003-04-07 12:59:11	9	10	2911	0	898	5047	4017	445.50	29	80.32	CHANGED	lAshhGAushuDuFhlAF+lPNhlR+lhu..EGuhssAFlPlasctp.........stccuptFspplhslltsshlllollh.llsu.hlltlhusGh.........st-shpLssthhplhhPalhhluLsulhsulLNstc+FhssuhoPllhNlshIhslllhtsphs...hh..........u...LulGlllGGlhQhLhplsslt+tGht.................hc.hhshp-psl+cllphhhssllusulsQlsLhlsptlASh......lpsGuhuhltYusRlapLPlGlFululuTllLPplS+shtsp-ts......phtphhspul+lshhlhlPsohulhlLutsIlslLap+GsFstp-sttsuplLtsaulGLlsauLhplLtpsFYApc-s+oPhplullshllNhshs.....llhhsshussGlAlAsuluuhhshshLahhlt+phh........hh.ttththhltp..hlsshulhusllhhlpphhp..asssphhhhhht	............................................................................................................................................................................hAthhGA..G..h..s.sDAF.h.lAh+lPNhl.R.c.l..hA..EG..A..F.u.p.A...FV.P..l....hschp..p...........................pspc.t..spt...a....s...sp..l...h...s..h.l.s...h..h.l.h.l....l.T...l.l.u...h.l...huP...hl.....l.h....l...h.u.s.Ga..........................sspp..h..s.Ls....st....hh+.I.h.h.P.a....l.h..hl.u.Ls.u..lh.u...u....l.....L....N....s.h....s...+....F....u.h..s..A...a...u..P....l.....l.....h.N.....l.....s.....h....I.....s....s.....h...l......h.....h...s....s....h....h....s...........s.hh.........................u.........L.A.h...u.l...h...l.G...G...l.....l....Q....h...l...h...p...l.......s....h.L...p.+..h...G.hh.............................................ht.s...c...h...s....h....p......c...s........s......l....p....+........l........h.....p....h.....h....h.....P.....u....l........l...u.....s.......u..l....s......Q.....l..........s.....l........l........l....s.....o.......h........l......A.S.h................................L..s.s.....G....u.....l....S..........h..........h.......h..........Y......A.....s......R..........L..........h........p.....h..........P........h........G..........l........l....G..l....A....lu.T....l..l....L.....P.p.L.S+.t...h.ss.s.s.ps......................p.hpph.hshul+hshlls.lPuulul....h...lLu.........tPlst.sL.....F..p......h.............G..p.....F...s...s...t....D...s.....t..h.s.u...t.u...L.h.s..Y..u.l....G...L...l.u...h.h....l.h.+...l....L.s...uF...Y......A...+.p.D...s.+..T....P.l.t....l....u..l...l...s...l.l.l.sh..l.hs.......................lhh..h......h.........h..........t.......h......s....G.......L....u.....l...u..t....u....l....u....u....h....l.s...s..s...l....L....h.h...h..L..p..+.p..hh....................h.t..s..t......t..h...h.h..h.hhp........l.hlu.s...h.l.h..u....s.s....l....h.h.h.......h.....................hh........................................................................................................................................	0	310	608	772
+3449	PF02344	Myc-LZ		Myc leucine zipper domain	Bashton M, Bateman A	anon	Pfam-B_829 (release 5.2)	Family	This family consists of the leucine zipper dimerisation domain found in both cellular c-Myc proto-oncogenes and viral v-Myc oncogenes.  Dimerisation via the leucine zipper motif with other basic helix-loop-helix-leucine zipper (b/HLH/lz) proteins such as  Max Swiss:P25912 is required for efficient DNA binding.  The Myc-Max dimer is a transactivating complex activating expression of growth related genes promoting cell proliferation. The dimerisation is facilitated via interdigitating leucine residues  every 7th position of the alpha helix.  Like charge repulsion of  adjacent residues in this region perturbs the formation of homodimers  with heterodimers being promoted by opposing charge attractions.	20.50	20.50	21.30	21.20	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.22	0.72	-7.47	0.72	-4.32	2	981	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	838	4	26	560	0	27.60	84	13.20	CHANGED	u-Ep+LIuEK-.LR+RREQLKHKLEQLRNSpt	.SDEHRLIAEKEQLRRRREQLKpKLpQL.......	0	2	5	9
+3450	PF01056	Myc_N	Myc_N_term; 	Myc amino-terminal region	Finn RD, Bateman A	anon	Pfam-B_387 (release 3.0)	Family	The myc family belongs to the basic helix-loop-helix leucine zipper class of transcription factors, see Pfam:PF00010. Myc forms a heterodimer with Max, and this complex regulates cell growth through direct activation of genes involved in cell replication [2]. Mutations in the C-terminal 20 residues of this domain cause unique changes in the induction of apoptosis, transformation, and G2 arrest [3].	22.20	22.20	22.40	22.30	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.43	0.70	-5.27	9	1946	2009-12-11 14:44:54	2003-04-07 12:59:11	13	10	1164	2	129	1419	1	143.50	44	69.28	CHANGED	MPlsuShssKNYDYDYDSlQPYFYhDp-D.sFYa..pQps.phQPPAPSEDIWKKFELLPTPPLSPSRRsSLu........................TA-QLEMVoEhLG........sDsVNQSFICD.ushupoFlKSIIIQDCMWSGFSAAAKLEKsVSE+LAShpAuRKEsshusss......................uussRhsusYLQDLusuASECIDPSVVFPYPLs-su........pss............sAsP..............psh.shcssPs....uSSSSGsDo..........-pp---EEEp-EEEEIDVVTVEK..ppp+pcsssSto..............ta.SPLVLKRCHVshH.QHNYAA..PST+.cDtPusKRl+LEup..spslpth.s.....pRKCsSP	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...p.pp......t....s..........................s+s.tSPL..V.LKRC..H.Vs.hH..Q.HNYAAP.......P.S.T+.....h-....Y...P..u....uKRh+L-u.............uRVLKQISs.........sRKCsSP..........................................................................................	1	13	28	56
+3451	PF01669	Myelin_MBP		Myelin basic protein	Bateman A	anon	Pfam-B_1868 (release 4.1)	Family	\N	22.00	22.00	33.60	26.40	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.84	0.71	-3.87	5	142	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	42	9	32	174	0	115.40	55	72.19	CHANGED	MASASTSDHARHGhGs..RHRDSGLLDSLGRFFG..GDR+VPRKGpGKs...shtttl..hPp.+tttttst...s-ssVVHFF+shhoP...ss.ptthpthu..ho.................h.p.pppuh+u+K....-GpGs.....chG......tptpuSP.SRR	................hAoASThDHARHGahs..RHRDoGlLDSlGRFFG..GDRs...sP+RGSGKss............sRssHhGSLPQ.+s...pH.uRst...D-NPVVHFFKNI.VoP+...........sPPspu+utth.......t........................................................................................................................................................................................................................	0	1	2	10
+3452	PF01275	Myelin_PLP		Myelin proteolipid protein (PLP or lipophilin)	Finn RD, Bateman A	anon	Prosite	Family	\N	20.40	20.40	20.40	23.30	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.79	0.70	-5.03	7	395	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	126	1	135	334	0	203.20	47	86.95	CHANGED	GCaECCI+CLGGVPYASLlATlLCFsGVALFCGCGHEALoGTEpllEpYFS..pNhpDahhLhsVIphFQYVIYGlASFFFLYGILLLAEGFYTToAVKplaGEFK..........TTsCG....................RClS......shFlhlTYlLslsWLuVFAFSAlP...VaIYaNhWoTCQsls.ssps.ssshtplCsDsRQYGllPWNA.PGKlCG...sLtsICpTsEFphTaHLFIsAhAGAuATllALlpYhhusoaNaAVLKhhuRtst.p+h	.................................Ghh-CCh+CL...sul...PaASLlATlLha.GVALFCGC.GH.ALouT.tllc.paFp......psh.t.Dh....lhph.Iphhp.YV..IYG.lAuhFFl.YG.llLL.sEGFaT..T.u.Al..+.c.l.a.G-.aK..........sThC.G................................R.Clo.......................................u.hFlhlTYlhhlsWLhV.huFoulP...Va.haa.NhWo.hCpshp.spts.............plChDh...............RQa...G..ll..P..h...s....s......s....h..K...............l.C.ss...........sh...phCpo..sE.h..ho....acLFIsAhsGA.u..hsl.luh...............lp...ahhhhohNaAhl+.hs+.pt...............................	2	31	42	79
+3453	PF00063	Myosin_head	myosin_head; 	Myosin head (motor domain)	Sonnhammer ELL	anon	Blastp MYSA_HUMAN/1-840	Domain	\N	19.10	19.10	19.20	19.10	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	689	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.23	0.70	-6.49	24	7667	2012-10-05 12:31:08	2003-04-07 12:59:11	16	484	1348	171	3682	6883	268	481.40	32	44.72	CHANGED	s-DhstLohlsEsulLcNL+pRYt.sshIYTYsGhhLlulNPa+pls.lYopchlptYcG+p............+tEhsPHlaAlA-pAYRsMhs-pcsQsllloGESGAGKTEsoKhlhpYlAuluussst..................................................p.tplcpplLpuNPlLEAFGNAKTsRNNNSSRFGKalcIpFstsGph....sGupIpsYLLEKSRV...lhQspuERNaHIFYQLLuGsssp..+ccLpLs...............sspsYtaLspsu....shsl.........................sGlDDsp-FptsppAhcllGhocp-ppsla+llAulL+lGNlp.Ftpst.....ppptu.............csppt.hpthutLhGlsstshtpuLhp.plpsG........pphlsps.shppAhhu+DALAKulYuRLFsWlVs+lNpsLstpp......................................ppsthIGlLDIhGFEIF..-hNSFEQlCINasNEKLQQhFscphhphEQEEYh+EGIpWshI-a.hDspssl-.LIEp...PhGIlulLDEpshhP+u....oDpoFhpKLhppa.spps...pa.p+s.c..........tspspFtlpHYAGcVpYsspual-KN+DsLpssllslhpsSps.sllsplFpp.p..............................................................tttpttpspptph.pTsutpa+pslspLMpsLpss...sPHalRCI+PNcpKtsspa-sphVhpQlpssGlLE..slRlpRtGFssRhhascFhpRYplLsspsh............tsscpusctlLppl......sh-...tppaphGpTKlFh+	......................................................................................................................................p...t.........h.....l...Ra.....................................h.....a................o...............u...........h.h.ls.hNP....h..t...h.......................t..........t.............h.......t.......................................................t............P...Hh..ashs..p.s.a.............h..................h................................................t.....................s.....Q.....s..h.l................h................o......G.......E.......SGuGK..T..........s...........s.K.......h..l...h.p.....a..h.....ut...l.u...s.......tt......................................................................................................................................................................................................................tplc.p..p..l...........l....tu............NP..lL..E.....A.FG...............N.AKTh+N.s...N.............S.............SR...F..............G....K.a.l.c.........l...p..F.....s.......p.G.t.l...................................uu..p.l..p...............p...........Y...............L.L...E........K.S.........Rl...................shQ............t.s.E......Rs.aH........lFYp..l.h..s.s....t....p.................p..............hp..h.h.l.t............................................ss..p.a..tal.sp....s......................ph.p.l............................................................................................................s...h...s.....D....t....p......p.....h............t.......h......................p.......A....h....p.hl.G.hs.........p...c................................sl.hplhu...u...l.....h.+...h..GN...hp....Fpttt..................t.t...p..ts..............................................................sp...p...........hp.....hs.....u..........Lh..sl.....s...........t...p.....l....ps.....l....hp..ph.hst..............................................t-h.l...p...s..s...h.t.p.......s..................sh..s...uh...uKslY.t..p.hF..a...............h........l.......t...lN..t....h....................................................................................................lu..l..L....Dh....h.G..F.E.h.....................t.N...............s...h...E..Q..h..h..lN..hs.........s.E..p..............LQ........t......a..p...................h............hh...-........p.........p...................................Y.....t....E..........t.....l................h.........................................l......p..a...............s..................t...............h.h.................p.........l.......l.............tt.............................................................u..............l...h..hl..p-ts...h...t.s...............sp...t...hh.t....p.h...t.........t...tt...................h.................................................tF.l...H......a..u.s..........V.......Y.p....h..........t....h...h.....+...N...-.....h...........p.h....th..h...............t.........u......t.......................hh.......h.h...................................................................................................................................................................................................................................................................................sh..s....h...p.........p.h....L..h.t..l...tt.................ts.al+C..............l..............h......s...................N...........................................................................................................................h............p.............hhtQlp...t.hhp....hp..h..t...........u.a................s......p.......h.......hh..............a...........h......................................................................................................................................................................................................................................................................................................	0	1142	1634	2706
+3454	PF01576	Myosin_tail_1	Myosin_tail; 	Myosin tail	Bashton M, Bateman A	anon	Pfam-B_356 (release 4.1)	Family	The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types [1]. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then  assemble into the macromolecular thick filament [1]. The coiled-coil region provides the structural backbone the thick filament [1]. 	51.00	51.00	51.20	51.00	50.90	50.80	hmmbuild  -o /dev/null HMM SEED	859	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.14	0.70	-13.91	0.70	-6.82	15	2444	2009-01-15 18:05:59	2003-04-07 12:59:11	14	63	325	2	1048	2212	11	548.10	35	44.88	CHANGED	-hEpp+c-lEpsLp+KEuElstlss+lE-EQshltpLQ+pl+-LpuRIcELEE-LEsERsARsKuE+pRuDLucELEELuERL-EuuGATuAQhELNKKREAELsKLRRDLEEuslpaEsslusLRKKHsDAlsElu-Ql-QLQKsKuKhEK-KuphptEl--ltupl-phsKuKtssEKhsKphEsQlsELpsKhDEhsRpls-lsopKuRLssENu-LsRQlEEtEsplssLo+hKupLsuQLE-A+RsLEEEuRpRssLpupl+slppDhDsLREplEEEsEAKu-LpRQLSKANuElpQW+oKaEsEuht+sEElEEhK+Khpt+lsEhE-plEutpsKsssLEKsKsRLpuElEDLpl-lE+usutsupLEKKQ+sFDKlluEh+pKs--lpsEL-sAQ+-uRshSoELa+LKsph-EstDplEuL+RENKsLuDEl+DLs-pLuEGGRslHELEKs+RRLEhE+-ELQuAL-EAEuALEpEEsKshRuQlElsQlRsEhERRLpEKEEEhEspRKNppRsl-SlpAoL.EuEsKuKuEshRlKKKLEuDINELElsLDtAN+usA-tpKslK+hQpQl+-LQpplE-pQRp+--scEphthAERRsssLpuElEELRssLEpuERuRKtAEsElsEAs-RlsELsuQssoLsupKRKLEu-lsslQuDLDEshsEh+sA-ERu+KAhsDAs+LA-ELRpEQ-pop+lE+hRKsLEpplKELQsRL-EAEusAlKGGKKhIpKLEsRVRELEsELDuEpRRptEspKshRKt-R+lKELphQsEED+KNh-+hQDLlDKLQtKlKsaKRQlEEAEElAshNhsKaRKhQ+ELE-AEERADpAEpsls+lR...uKuRs	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...................................h.....h.............ph...p.p.p.............t....t........++...p......phtt...t.t.t.......th..c+.t........p.h..-hpsh............hp...t...t.......h.pp.p....p...hp..p...........tp.p..........t..p.......h...pt.....tp.p.h....sch.t....httth....p.p............th.t..t.......hp.......p.........t.h.t.......t.......cht..p...h........................tt...tt.tt.p..h.tphpt.hpthp........ph......c.p.t.......hc-..ts.......thp.............c.......tt..............h.Rhphp.h.....t.th+tphpc.ch.t...t+-.-p.-t....h..+.p.t..t....h..cp.hp.tL..-..t..Ehc.......+..t.h.t.+...cchc.plt...............p.h..p.....thp.tts..p.............t.........-...........+p....h....c..............p................p.............h...p....................-....h...............hth...--t........t........pchht.p..t..pcc....t.hts-h.p.............hp...htts.+t.++.h.......c.-h...............-..httph.......t.........tt.......t....t....s....s.......h.........p...tt....pp....h-tcl.plpt-h--..pp.p.h.-+hc+s...p..h.t........h.t.....p-Ltt.Ep.......p..tttc..E.p.+pphEtp..............K-.Lp.+Lp-..hEt.s..hp...t........h.+.t....lttLEs.+.................l....tpLE..tpl-tEp....+..............ct....ts.+thR+h-++...lKEl..h.Q.s........-..........-..-++p..p.h.p-.h-Khp.+lK.....thK.RQ.h-Eu................Ep.sp...s..ph.R+hQ+EL--tpEts.-...hppplpth+.....................................................	0	216	306	674
+3455	PF00819	Myotoxins		Myotoxin	Bateman A	anon	Pfam-B_1337 (release 2.1)	Family	\N	25.00	25.00	80.40	80.30	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.44	0.72	-3.90	2	29	2009-09-10 20:59:54	2003-04-07 12:59:11	12	1	8	2	0	31	0	41.80	88	77.46	CHANGED	YKRCHhKtGHCFPKphIClPPSSDFGKMDC.W+hKCCKKGSsp	YKpCHKKGGHCFPKEK.IClPPSSDFGKMDCRW+WKCCKKGSsp..	0	0	0	0
+3456	PF02384	N6_Mtase		N-6 DNA Methylase	Bashton M, Bateman A, Mian N	anon	Pfam-B_508 (release 5.2)	Family	Restriction-modification (R-M) systems protect a bacterial  cell against invasion of foreign DNA by endonucleolytic  cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (Pfam:PF01420), and R [4]. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.90	0.70	-5.35	15	7778	2012-10-10 17:06:42	2003-04-07 12:59:11	11	73	3514	13	1474	8902	2092	276.20	22	51.07	CHANGED	pstDlhGDsYEYlLupFApspGKpuGEFaTPpsVocLlsclL....-spssc.IYDPAsGSGuhLlpsp+altt........sspspslsla....GQEhstoTapLA+MNhhlHsIchstht...lphuDTLtsspap........-tphDhVlANPPast+.W........ssssltsDs..Rap.t.....hsPpssA-aA..al.HhlhpLussG+AAlVlssGsLac.GusEucIR+tll-pshl-slIuLPspLFas.TuIPsslllLsKsKs.........pcscVLFIDAsp.atpcs..+ppstLos-cIpKIs-sapph.....................c-ls.....tFu+sAol-EIpcNDYNLslsRYVsstcpc--	........................................................................................................................................p...p.huph...Y.E..h..h.lt.............p.............h................................t....t.............s.............p..........p..s..Gpa..a..T.P.p.t.l...s.c..h.h.s....pll.........................................p.s...p.......t...t.....p....l.....h.....DPs.sGoG..u..h....L....h.p...s....h....p....h...l............................................................t.p.........t...p...h.....p.h.a..................G......E...h.....s...............t.......s...h.....t.........l.....u.......t............h.....N........h........h.......l........+.....s......l........p...........t...............t....................lh......s...s.....o......L..p...p..s.hh....................................................tph..D...hl..luN.P..P.a....u..h..p..................................tt..p..p..h.......t..p......s....................h.................................hs.s.p...s.....p...s....p....h..h..............F....l...t.....p.....h.....l.....p...h..........L..............p..........s...............s..........G.........p......h......u...l.l...l.s.p....u..h.L.hp....s..........s......t......p......t....p...............l....R..p...h.l.l..........c........p.......s.........................l.c..s.....l.............l...t......L.........P...........s.......s...l...F.......h...s.....s..s......l...s...s..s..l..h...h..h.p....K.p.p.........................................tpp..p.l..h..h.......h..c..h...t....t............h....................................tt........t.p....h.........t...............................t..............p.........h.............h.........t.h..h.t...........................................................................................................................................t........................................................................................................................................................................	0	495	1021	1282
+3457	PF01555	N6_N4_Mtase		DNA methylase	Bateman A	anon	Pfam-B_164 (release 4.0)	Family	Members of this family are DNA methylases. The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.58	0.70	-4.87	49	7047	2012-10-10 17:06:42	2003-04-07 12:59:11	13	54	2966	14	1466	6738	4026	224.00	20	60.70	CHANGED	lcllhssPPYshspp........................................thsptps..........hppahpa.....hhphlppstcl.........LKssGslhl.ss.phht............................................................................hhthhhp.hs..ahhhshIhWpKs........t.shsp.pt..............phstspEhllh................asKscph....................................................hhshphhch.hpptpthphtt........................................h...........W......................................................................................................ht..ppppt..............H......ssp+PhtLhc+lI.phsop.........sDlVLDPF....hGS.......GTTshsAtpLsRp.......................aIG.hEhppcahc..hutc	.....................................................................................................................................................................................................................lchlhhDPPY..ht.p.................................................................................................t.t.......p...............................p..ta....h.p..h............h.......h..ht..hhcl.............L.p...s.G.s.h.hl....hs...pth.........................................................................................hhhh.h...p.............s................h..h....s.......l.h..Wppt............................................hsp....t........................................................................hh.t.....t...t..E..l...hh.................................................................................h.....Ks.tt..............................................................................................................................................................................................................................................................................h..........................W.....................................................................................................................................................................................h......t..............................................a..........s..s...KP.t...L....lppl.I....t..h....s..o..p................................................s..s...l...V...L.DsF....sGS.......GTTsh......s...uh..p.h.s..R.p................................................hlu.h-.hptthhp.....t...........................................................................................................................................................................................................	0	537	1019	1270
+3458	PF04245	NA37		37-kD nucleoid-associated bacterial protein	Mifsud W	anon	COG3081	Family	\N	24.60	24.60	25.60	24.90	23.10	23.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.20	0.70	-5.10	105	1727	2010-01-13 16:22:14	2003-04-07 12:59:11	8	1	1574	0	252	1017	43	316.50	30	96.20	CHANGED	llHplsppsp........................phhhpsp.h.h..ssphp....t..hltchhpth..spc.sttsauph.........................t..thsttlpphhp...t........ppsFhphSpphuppLh.pphpc.p...hs....uGpllhspa...........p..t....sp.........hlhlhhlcpcpuhhhspp............lchp.p.ptl.........sls+lphuAhIslsph..............................phhlshlcscsscp......sstaatc.FLuspp.thsspppocshlpslccaspst.......lspppp.p.....ph+pplhsahpc.......s.-..plslpcluspl..................t.p.....th..sFt....pahppp..th.plp......ps..Fssspsslcph.t+h..sspstulslphctphhs....p.....phh..s.pss-.s....l..pIps..h.s.hpcplpc	..........................................................lHQl.pccp..........clhLp-phL.s...spplp.....p.hltcltchh....ssc.p.psauha........................ps...hsph.L.p.hhp....s...............pcDFlth.SpshsppLp.-.............th..sc.s........hs....uG.llFspa........................phhu..s-................................aLhlhhls.ppohphsps........l-ls.s.phL....................sls+hDhsAcIsLoph..............................spalsalcsR.ls+c.......ls.Fh..hc..FLuss..slssKtps+s.Lhpssc-...astpt.....ph-ctpp..p.......pl+pp...lasahpE.......u.-....El...pl...c.pLup-Lh..............ss..........ps...sFh.....-aspEp........th..tlp....Es..hs.s.D....+..p.s.lcph..pKa.....sutusGlslsh.ss..lhs-........chh...s..ssD.T..........l......hIKs...h...h...................................................	0	62	131	201
+3459	PF01235	Na_Ala_symp		Sodium:alanine symporter family	Finn RD, Bateman A	anon	Prosite	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.50	0.70	-5.90	6	5556	2012-10-03 01:44:59	2003-04-07 12:59:11	12	8	2931	0	865	4003	1762	405.60	38	87.29	CHANGED	hhchhp....hhu++scuG..sloSFQALsTuLAuRVGoGNluGVAhAIuhGGPGAVFWMWVsAFlGMATuFsEsTLAphYKh+Dp-GshpGGPtYYlp+GLuhRWLullFAlh.llloFGhlhsulQsNuIAcAhssuFshsslVTGIlLsllsuLlIhGGlKRIAtlophlVPhMAllYllsALsIlhhNI-plPsVIttIhcSAFuhptAsGGhlGusl..AhhhGlpRGLFSNEAGhGSAPpAAAAAcsp..HPspQGlVQhlGlFlDThIlCTsTAllILLoG.h.......................................hss.pLcG..............................................................hplTQtAhppthG.uaGupFluluLlLFAFSollu.YYYuEsNlhaLh.sph+ulh..haRlshlAhVhaGoltshsllWphADlshulMAlhNLIAIlLLpplsachhKDYhcQhKpGhpP.Fcspch	................................................h...............t..t..p..p..p..p.u...slSsF.Q.ALssuLAupVGoGNIAGVAsAI.......s........hGGPGAlFWMWlsAhlGhAotasEuoLA.hY......+.............p...+..-..t...s......G..p.ap......GGPhYYl........p.........+....G.L.......s.........t...........+..............W........h.......u.......l....l.......F.....A.....lh....l.l......l........u........h........G......h....h........h.....s....sl.....Q.......u........N.......o.......l..................u..................p..............u...............h................p...............s................u..............a..............s..................h.............s..............s...............h..............l..............s.................G.............l........l..L.s.......l...ls..u...l.l.Ih.G.G.l.+..p..Iu.plsphlV..PhMAlhYllsulhllhhNhsplP....sshthIhpu.A.F...s..h..p....u......u.s.G.G.h.hG...s...s...l..........................h.GlpRGlF..SNEAGhGSAP.AAA..uA.psp..............H....P..scQGllphhGlFlDTlllCThTAhlIL..l....o...G....h...................................................................................................................t....s...s..h...p...G......................................................................................................................s...t....l.Tpt.Ah...s..shh......u.......s......h.......G..s.....hh.......l.s....lu....lh....hFA..Foollu.hYYuEp.s...........lt.a......L.......h....................s.........p...p.....h.....l..h..............laR.......l...l...h....l............s.....h.l..hhG...u.......h.........h...........s.......l...s....h.........l...WslADlh......hGlMAlsN...LIAlll...L...u....thshphh+DY......p.p..h..c....t.................t................................................	0	285	542	723
+3460	PF03390	2HCT	Na_citrate; 	2-hydroxycarboxylate transporter family	Mifsud W	anon	Pfam-B_3683 (release 6.6)	Family	The 2-hydroxycarboxylate transporter family is a family of secondary transporters found exclusively in the bacterial kingdom. They function in the metabolism of the di- and tricarboxylates malate and citrate, mostly in fermentative pathways involving decarboxylation of malate or oxaloacetate [1].	25.00	25.00	25.00	27.90	22.10	24.10	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.36	0.70	-6.10	36	838	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	694	0	149	549	5	398.60	39	93.58	CHANGED	+IsslPLPlallhuslllluhhh...........spLPssMlGuhulhhlhGhlhGpIGpRlPIl+s.lGGuAIlslFlsohlVaasllspsslcssoshM.Ks.......u.sFL.hYIAsLlsGSILGMsRclLl+uhl+hhssllsGslsAhhsGhlVGhlhGh..........shpcshhaIllPIMuGGhGtGAlPLS..hYuplhG.hsppphhSpllPAlhlGNlhAIlsAulLsplGc+pPcLoGNGp.Ll+spp.....htsp.pcpptplshpthGsGlllAsohFhlGtllschl.......sl.uhshMIlhsAllKhhsllPpphcpGAhphapFhusshTasLlsGlGluassLsplluAl.ohsalllshslVluhlhsuhhlG+lhshYPlEuAIsuG.CtushGGTGDVAlLSAusRMpLMPFAQISoRlGGAhhlllAslL	...........KIsulPLPlYlhh..hh.llhlsthh..............spLP.s.shlGuhAlhhhhGhlhGpIGp+lPIhpp.lGGsulhshhlsuhhVaasll................sp..s..lcusst.hM.cp.......................u..NFL.haIAsLlsGSILuMNR+lLlpuhh+hlssllsGhlsAhhsGhlVGhlhGh..................shpcshhalllPIMuGGhGtGhlPLS..hYuslhG...tsppphhuplIPhhhlGNlhAIlhAulLsplGc+hPp....LoG.pGp...Ll+pss.........sp..pcppptplshpthusGhllAsohFlhGhllp+hl...........sl..s.s.h.Ml.llsshlKhhslhPschcpGAppl.cFhSpslTasLMsGlGlshhsLp-llssl.ohs..lllshslVluhlssuhhl.G+hhshYPlEuAIsuu.CpushGGTGDV.AlLSAuNRMsLhsFAQIuoRLGGAIsllluoll....................	0	28	64	100
+3461	PF03553	Na_H_antiporter		Na+/H+ antiporter family	Bateman A	anon	Pfam-B_620 (release 7.0)	Family	This family includes integral membrane proteins, some of which are NA+/H+ antiporters [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.93	0.70	-5.39	38	7404	2012-10-02 15:12:49	2003-04-07 12:59:11	9	9	2159	0	1156	6794	758	256.90	17	76.09	CHANGED	sssFGs.ttShlu.ssshusthhtstlhsphp...........h.hhhpshshtlhuhhhhhhluhlhh......hhhslsshhpp..tsh.....................phshhthtt.............Phhslhhhslhth.hhsshsh.shhs.shshthh...hpssshhtshhhuuhsuhhhthhsth.......htphsshlscG.hpsMhhslhlllhAhuhuullpcsG.hssllpslspth.ps.........hthhshlhhlluhhlshusGsuauolsIhsslhtshstphshsh..........hshsusltsuushu-shsPhSsoslhsssshts...plsplp.sshshhhhhs.h.hhlhhlhhGh	......................................................................................................................................................................................hhhs....s.h....h..h.h.....h.........h.h.ttht................hh.h..........h.h.shh..hh.h.h..h............................th..........h.t......................................................................................ht...h.....................................s..hh.h.h..h..h..h.......h.h......t.h.....h.hh......s........h.........h...........h.................h..........h.........s........h........h.h.thh.................hp................s....................................................h........h...............s.......h.........h.h..u....hh....h...h..hh.h.th.............................h.tp..h.......p...h...h.....s.....c.....G....h.....p..s..M.....h.........h....h.hl.h.....lh.uh.u..h..u.ul..h.p.....p......h......G.....h.ls...s...ll.....p.....t.....l....h....ph.h...ps....................................t.t.h....h.h..h..s.h.h.l.l.u.hh..l..s.h..u..h.G.s.u...as....o.ls.l.h....u.s.l.h.h.sls.p.p.h..s.ls...........................hhh.s.u.slt...su...us.hs.s.th..Phu..s...s.s......l.....h......s........sh....h..........................t..........h.......s...........h............h........h..s..h..h.....h.h..............l..hhh...............................................................	0	401	740	997
+3462	PF00287	Na_K-ATPase		Sodium / potassium ATPase beta chain	Finn RD	anon	Prosite	Family	\N	23.30	23.30	23.30	23.70	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.96	0.70	-5.63	11	608	2009-09-11 13:38:36	2003-04-07 12:59:11	13	6	122	10	324	552	0	246.50	31	90.97	CHANGED	MA+.cpccs........p.supWKcFlWNPcppEFhGRTuoSWshILLFYllFYGhLAGlFshTlhVMLpTls-apPKYQDR....lAsPGLhhpPcs..sp...hEIsFssu.sspSappaVpsLppFLcsYssopQsp....hpsCs..PscYh-pss.s...pspKKuCpFptphLG.sCSGlsD..sFGYs-GKPCVllKhN......RIlGFpPcs...............s.......ssh.lpCsuKcsE..tpplsslpYaP.s.....GshsLhYaPYYGKphpssYlQPLVAVpFsNlo..tssEltlECKla.usNlphs-.+D+F.GRlsFK	.......................................................................tth.ppah.a...ssp..pt...ph.hGRTstuW.........hh..Ihl....FYlhFYs.hLsuhFshsh.h.s.h....h...T.l.s..s.h...h..P....p...a...p..-p...................hs...s..P.G......l....hhtP.s............tt.......h...l..a..phs..c..spoaptaspplppFL....p.......Ypss.ptp..........sCs.........tthh.p.t............tpsCpFph.p........L.....t....sC....Suhp..D.....aGYpp...G.p.PClhlKhN......................Rl.lsahPp..........................................................t..............ssh...ls.Cp.s....p......p........t....t......c.........t..p.......p.......l.......sp.l.......pYaP.s....................sh..s......h.h..Y..a...P...Yh...s...............p....s..sY.....h.p...P....LVAVp..Fh..shs............hshtlplcC+hh.upNl..s.p.tcc.h.Gphth.............................	0	79	107	205
+3463	PF00939	Na_sulph_symp		Sodium:sulfate symporter transmembrane region	Finn RD, Bateman A	anon	Pfam-B_1100 (release 3.0)	Family	There are also some members in this family that do not match the Prosite motif, and belong to the subfamily  SODIT1.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.60	0.70	-5.62	11	6208	2012-10-02 15:12:49	2003-04-07 12:59:11	14	27	2554	0	1377	7719	2167	426.10	24	91.05	CHANGED	tsphhpLlhhlslhllIahlPsPsGlsspAWphFAIFhusIlGlIhcPlPhuslAlhululh.llstsLs..................lstuLSGFussssWLlFsAFhlutGah+TGLG+RIAhhhlphhGpoo..LsLGYullhs-llLAPuhPSsTARuGGIlaPllpuLss..........uhGSsspcs.................................o.+plGuaLMhssh.uosITSuMFLTAMAsNsLshslhsp...hsGhploWhpWhlA....AlssGllhLllsPLllYhlaPPclcps.............-shphAcpcLcpMGPhstpE+tllslhlLsLlLWlFGs...........pls......lsAoTsAllslulhllhp.....................llsWc.DllpppsAWsTllWaGuLIsh..AshLspsGFlpWlusshsshlu..uhssthuhhlllhla.ahsHYhFASsoAaluAMhPlFluVupul.G.ss.hhhuLsLsFusulhGhlT.YGoGPuPlhaGuGYlsspcaW+hGhlluIlslllaLslGshWWphLuhh	..........................................................................h............h.h..h...h.h..h.h...h...h..s...h.....s...................s.........h.....s..................s....h..h.........h.........hu..............l..hl..............hh...hl..h...h...l.h.c...s...l.Ph.s..s.s.u..l...l.s...h..s.lh.....lhs.hh.......................................................................................p...s.h.u.u.a.us.s..slaL.hhuu..Fhluhu..hpc.ps....L....s...+R.l.A..h..h.l..l..p...h..h....G.p...p.s.................l.h..l..u...a...h..h..s..h..s.....l...h..h.....s..s..su...s..oA..h.h..h..s..l..h..h...s.l.l...p.s.ls.........................................h.t..s.p...p.p............................................................................................................................................................................................................................t.p...h.u.th...l.h..h.s.h.hhu.s...s...lsu.hhh.hsu....s.s...s.Nh.l.hh.t..hhpt....................t..h..p....l..s..ah..p..W..hhh.....uh.P....s..l...l....h....l.....h.l...h....h.......l.h....h.h....h.a.........s...p....h....p..p...h....................................................................t..s....t...h..h.....p..p...c.h...p.p...h...G.............h..s..h.....t...E......h......h...h....l.......s.......l...h..l....l..s..l..h......h..........W......h......h..t.s..........................................ht..................l...s...s..s...s..l..u...l...h..s....h.s..l..h....h..h.hs.....................................................................l..l...s....W...c........h.....h.....p.....p..p.....h.s......W.....s.....s.l.....lh.....h.uuh..lsl..............uss..L..p.p..oG.h..hp.al............uptl..ts.h..hs...............h..t..............s.........h...s.h.h.h....l..............l..h...l...h...h.h.h..h..h......F.s..S.s..o.A...ts....s....h.h.h....P.l...h....hs..l..........u..........h...u...h.......................u.......h..........s......s......h......h....h...s...l.....h....h...........s....h....u....s..u....h...s......hh....h...Phus.......s..P.....s..s.....l.......h..........a........G........s........G......h........l.....p..............h.....p.......c......h..h...+....h......G.....h....h....h......s....l...l.s...h........l...l...h.h...h.h...s.............hh......h...........................................................................	0	425	767	1127
+3464	PF04902	Nab1		Conserved region in Nab1	Kerrison ND	anon	Pfam-B_6188 (release 7.6)	Family	Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription  factors [1]. This C-terminal region is found only in the Nab1 subfamily.	25.00	25.00	26.50	44.50	17.60	18.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.04	0.71	-4.76	2	61	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	38	0	27	45	0	154.70	68	34.82	CHANGED	GERDELSPKRIKVEDGFPDFQ-sVQTLFQQARAKSEELAALSSQQsEKsMAKQMEhLCsQAuYERLQp.ERRLoAGLYRQSStEHSPsGLsSDsSDGQGERPLNLRMPNlQNRQPHHFVsDGELSRLYsSEAKSHSSEsLGILKDYPHSAFTLEKKVIKTEPEDSR	..GERDELSPKRIKlEDGFPDFQ-oVQTLa.......QQ..........A..+AKSEEhsALuSQ.........Q.sEKV.MA..KQMEFLCsQAGYERLQpsERRL.SAGL.YRQu..SEEHSPN.GLsS.D.sS.DGQ.GERPLNLRMP..N..LQ.NR.....Q.P..HHF.....VlD..........G..........E..........LSR.L.Y.s...S...E.AKS+SS..E.SLGILKDYPH........S.AFT.L.EKKVIKTEPEDSR..........	0	1	4	10
+3465	PF01849	NAC		NAC domain	Bateman A	anon	[1]	Family	\N	21.30	21.30	21.40	21.40	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.73	0.72	-4.44	91	1327	2009-01-15 18:05:59	2003-04-07 12:59:11	13	15	510	10	771	1213	39	57.30	36	25.22	CHANGED	pKKhpphhc+lGl..cplsslpcVslpp.sctphlhhspPcVp..pu.s.ssoahl..hGcscpcs	...............-KKhpp.sl.pKLGl.....psls.Glpc..VshhK.sc..shlhhhsp.P.cV..............tS.s..usTahl.hGcuchc...................	0	231	389	577
+3466	PF00175	NAD_binding_1	oxidored_fad; NAD_binding; 	Oxidoreductase NAD-binding domain 	Sonnhammer ELL	anon	Prosite 	Domain	Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.61	0.72	-3.49	72	19747	2012-10-02 19:13:12	2003-04-07 12:59:11	16	239	4712	191	6047	15837	2129	105.10	20	24.44	CHANGED	hlu.GGoGluPhhshlpphhtt..p...........tspshl.haGs+spc.cll..hc-Elcphttph.t....hhh.h..........ppssss.tst+GaVpctl.c..ch.............ttth.lahCG.P.sMhcsspp	..............................hlu.uGsGlsPhhu.hl...pp...h..h..t.....p....................................................ptsp...h.h...l...h..aus...R..........stp....-.......h..h.........a....t.c....-.l.p...p......h..t.pph................h...h.hhh.............................spsp..s.....s..............................p.....G...h...l.s....p.....t..l....h...p..phht.................................t.s..s.p.l.a.l.CG.sssMhcsst.t......................................................................................	0	1691	3423	4899
+3467	PF03446	NAD_binding_2		NAD binding domain of 6-phosphogluconate dehydrogenase	Griffiths-Jones SR	anon	Prosite	Domain	The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.76	0.71	-4.40	163	12732	2012-10-10 17:06:42	2003-04-07 12:59:11	10	80	4225	91	3550	30059	15093	161.10	28	46.30	CHANGED	htpIGhIGLGlMGpshAhNl...h.ctGasVslas.Ro..t.....spscphhtp...u..........hhsstohp.-hspsh......chllhhVtsussVcsll.s........lh..stl........ptG..sllIDsussphpsspchscp.lpppG..ltalsusVSGGptGAtpGs.olMsG..Gspp.uacplpP.llpshus.........sls.......h.Gs	..........................................................................plGhl...G.L.G.h.M.......G....t...s....h....A..t..Nl.................h...c....t....G........a......s.......V......s....l.....a..s.....p.s......t...........p...t...s...c.....p...h...h..t.p....u.......................................st..s.s..t....o...s.p....-...h..s..p.sh.........................chl...l...h.........M......l..........s.........s..........u..........s...........s..........l.......c.........s..........l........l.......s.......................l..h.....s.t..h..................................................p..t...G.......s....l..l......l...D.......t...u.......s.....s.s........p..s.......s.p.c.h.s....p.......t.......l....p.........t......p..G.............h.p...............a.....l...-.........u....s...........V....S..G........G..p...t..........G...........A...t.p......G.........s.............olM..s...G..........G...s....c...p......s....a..c..p..l...p.P...lh.p.s.h.us...........slh.h.G.t...........................................................................................................................................	0	986	2066	2904
+3468	PF03447	NAD_binding_3		Homoserine dehydrogenase, NAD binding domain	Griffiths-Jones SR	anon	Pfam-B_459 (release 2.1)	Domain	This domain adopts a Rossmann NAD binding fold.  The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.33	0.71	-10.36	0.71	-3.70	30	6031	2012-10-10 17:06:42	2003-04-07 12:59:11	11	30	4281	27	1498	6276	2360	124.60	26	23.63	CHANGED	GhGslGsslhchLpcstt........slclsulsscc...hptt..........htshhsstshsssl-clls........c.sDllVEs.uu.pslcphshphLcpGhcllssshuAlu...shhtcLhphAcpsssclhh.	.........................................................................GhGsV..Gu.u..l.l..c...l..l...pcppptltt...............phshplp.lss..l.ss..pc......h.ptp........................................ht.t.t.h..s..s..t..t...h....s....p..s...h..p.....p.llp...............................p.hsl.lVE......l...u......u......s......p.....s.....s.....t.....s.....h..h..h.c..sL.p...p..GhHV.....V..T.A.NKs..hhA.........sahppLtph.A.cpss.hphhap.................................	0	464	940	1256
+3469	PF01210	NAD_Gly3P_dh_N	NAD_Gly3P_dh; 	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus	Finn RD, Bateman A, Moxon SJ	anon	Prosite	Family	NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain [2].	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.72	0.71	-4.50	44	5998	2012-10-10 17:06:42	2003-04-07 12:59:11	18	26	4763	27	1531	8856	4915	150.50	28	44.49	CHANGED	pluVlGuGuWGTALAtlLucsu........ppVplWspcs.........phhcplspp+p.NscYLPs.lhlPs.slpsssDLtcAlpsu-hlllsVPopshcplhpplpshl.....ppsshllt........ssKGl...Et.........sohphlScllpEhlstp....luVLSGPshAcEVAtth.osssluu...pstphu	....................................................................lsVl.G.u.Gu.a......GT.A.l.A.h..hl..ucsG............ppVh.lW.s..p..p............................................chh.p.p..l......p......p.......p.......+......p.......N..................p..........a.......L..........s.....s.......h............t.......h.......s........p.......s..........l...........p.....s.....s......s........D....l....t.........p...A.....l.............p......s......u...............-......h.....l......l.h.s..l..........P..o...........p...........s........h..c...p.........s..h..p.p....l..t..s..hl..............pss...s...h...l..l.t...........................ss..K..Gl................E.............................soh.ph...h...s..c.l...l...p..-.......l.stp.................luV.lSG.....P..saA.pE.lutt...oshsluu.ps.p..h.......................................................................................................	0	513	967	1299
+3470	PF01513	NAD_kinase	DUF15; 	ATP-NAD kinase	Bateman A, Wood V	anon	Pfam-B_797 (release 4.0)	Family	Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.62	0.70	-5.63	33	6066	2012-10-02 15:20:27	2003-04-07 12:59:11	16	26	4752	59	1890	6136	3391	258.10	24	81.92	CHANGED	plullssss....................ptpstthspcltchLhsp........shhhh.ttthtt..........................................................phhhhshphhcpss-hllslGGDGThlsssphhsp....slPllGlss.GshsFhsph..p.cshtphlsphlp.schplpct.....hl-...........................shlppspp...............hh..thslN-hslhtutssphhp..hclhlssshhsshts-Gl.............................lluTPsGSTuashuuGGsllpPsltsh.l....s.....hhhttcslVlssppplph.......ppsshlshDGppplpht.sshlplphu.pt.hhhlch	........................................................................................................................................h.......................................................................................................................................................................................................................s..p...p..s...D.lllslGGDGThLpAs.+t..h..tp...............s..lP..l....l.G.l....s........t......G.....p...L...G..F.....L....s.-.h...............psp..p.h....p..ph.l....p.....p.l..........h..........p...s..............p......h......p...l......p....p..+.......hLc.............................................................................................................................................................sp.l...p.ppsp.....................................................................hh.ph..h.A.l..N...E.l....sl....pp..u.s..t.sp.hhp...........h-l....hl...c.s.....p....h..h....p...s....h..puDGl....................................llSTPTG...STAY..shS...u.G..G...sl.....l.p.P.s.lp.u.l.hlsPlss.........+s.ht.sR...Pl...V.....ls.s.p.splplph...............tppshh....ls...hD.u..p...t..h..t..h..p.s...ppl..lphst...hphh...................................................................................................................................................................................................................	0	612	1178	1585
+3471	PF02540	NAD_synthase		NAD synthase	Mian N, Bateman A	anon	COGs	Domain	NAD synthase (EC:6.3.5.1) is involved in the de novo synthesis of NAD and is induced by stress factors such as heat shock and glucose limitation.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.63	0.70	-5.47	11	9645	2012-10-02 18:00:56	2003-04-07 12:59:11	12	26	4887	87	2593	10500	6866	175.90	22	39.30	CHANGED	llpclpsFl+phVpcsGs.pGVVlGLSGGlDSulVAhLshcAl.........Gp-psluLlMP.s..ssccDhpcAhslscpLuhphpplsIcshhpuasp....thppst....pchscGNlKARlRMshLYsaAsphshLVlGTuN+oEhhlGYFTKaGDGusDlsPIusLhKopVacLA+tls.....lPccllcKsPoAsL...asGQTDEcELGlsYc.LDplLp....hhp.t...p-..tthslstphscpltphlpKoEHKRc.P	........................................................................p.......hlt.p..h.h....p....p.....s....Gt.....c....p....l..l.......L.G..l..SGGlD...S..o....l...s....u....t....L....s...p....c.A..l.............................................u..p...p...p.....l.h....s..l.....h...l............s...........s..............h..................t..........p..........p............p..............p..............h..p..t......s......h......t.......h..h....p.t...h.....t.....h......p.....h.....h.....h......l.....s....h.....p........h..h...........t...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	860	1651	2190
+3472	PF00146	NADHdh		NADH dehydrogenase	Sonnhammer ELL	anon	Prosite	Family	\N	20.00	15.00	20.00	15.00	19.90	14.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-11.82	0.70	-5.37	23	21511	2009-01-15 18:05:59	2003-04-07 12:59:11	16	18	13672	0	1222	18971	2989	236.20	39	95.74	CHANGED	hhllshLhlIlsllluVAFLoLhERKlLuhhQhRKGPNhVGshGLLQPlADGlKLhhKEslhPusushhlFhluPslulhLullhWsslPhshshl..shNlGlLFhLAlSSLuVYulLhuGWuSNSKYuhLGuLRAsAQoISYEVoLuLILLol.llhsGSashsslspsQp.....hhWhlh.phPlhlhaaISsLAETNRsPFDLsEuE.SELVuGaNVEYuussFALFFLuEYuNllhMshLs.slLFLGu.h.............................s.hhhhhKshhlhhlFlWlRuohPRaRYDQLMpLsWKsaLPLoLuhllhhsulhl	...............................................................................h...lh.h..h.l....l....L...l.u....l....A....a...h....o..l......h...E.......RK.lLuah.QhR+GP........N...........h..........V...........G.......................h..........G......l......L......QPhuDulKLh.hK.E......l.h.Ptt....u.s........h....l..a.h.hs.Phl.u...l..h..l........u..lh.h..a.h..........l.......P.........h....................s..............h................s............h..............h........................................................s...........h......s....l...u..l.L..........a..........h..l........s..h.o.Sl..u..VY.sl......l..h........uG.Wu.S..N...SKYuh....lGul..Ru..sA.Q..sISY.E..ls.h.s.l.h.l.l...s........h......l.h..h......s........u.............s..........h...s...h.......p..h..........s.Qt..................................h.W......h......h......h...................h...s....h...h...h..h..a.....h....h..ss...l....A.......Es....N.R...tP.FDh...s...E...u..........E...pE....L..s...s.G..a......h...EY...u.uh.Fuh.h....h.h.u....E.Y.h.....t.h.h....hh.shh.....s.h.ha..h..s.s..........................................................................................h.hhhc.h.....h...h.....h.h...h.h...h.c.shsRh...Rhs...h.....hh..W.h....h......................h..................................................................	1	394	766	1015
+3473	PF02477	Nairo_nucleo	Nairo_nucleocap; 	Nucleocapsid N protein	Mian N, Bateman A	anon	Pfam-B_2892 (release 5.4)	Family	The nucleoprotein of the ssRNA negative-strand Nairovirus is an internal part of the virus particle. 	25.00	25.00	41.20	28.40	17.60	17.10	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.50	0.70	-5.79	3	472	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	16	1	3	283	0	180.00	74	96.38	CHANGED	MENKIcANNK-EFNcWFKpFuEKppLsssaTNSASFC-cVPsL-pacaKMALATDDsEKDSIYSSALVEATRFCAPIYECAWsSSTGlVKKGLEWFDKN..uDTIKlWDAsYh-LKsElPcsEQLluYQQAALKWRKDVGFcINpaTuuLoHsVlAEYKVPGEllhslKEMLSDMIRRRNlILNGGGD-APKRGPVSREHV-WCREFAuGKFlsAFNPPWGDINKuGKSGIPLlATGLAKLAELEGKcVhD-AKpoltsLcGWV--NKDpVDcuKA--LlpslpKHlAKAlELuKpSNALRAQGAQIDTsFSSYYWsWKAGVTPETFPTVSQFLFELGKsPRGsKKMpKALlSTPLKWGK+LIELFADDDFppNRIYMHPAVLTuGRMSEMGlCFGsIPVASPDDAAQGSGHTKuILNaKTcTEVsNPCAsTIVpLFEIQKsGa	..............................................................h.hpMA.ATDDupKDSIYASALVEATKFCAPIYECAWsSSTGIVKKGLEWFEKN....uGTIK...SWDEsYsELKV-VPKIEQLANYQQAALKWRKDIGFRV.NANTAALSNKVLAEYKVPGEIVMSVKEMLSDMIRRRN.lLN+sG.--ss...............................................................................................................................................................................................................................................................................	0	3	3	3
+3474	PF04131	NanE	nanE; 	Putative N-acetylmannosamine-6-phosphate epimerase	Mifsud W	anon	COG3010	Family	This family represents a putative ManNAc-6-P-to-GlcNAc-6P epimerase in the N-acetylmannosamine (ManNAc) utilisation pathway found mainly in pathogenic bacteria.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.22	0.71	-5.33	7	2374	2012-10-03 05:58:16	2003-04-07 12:59:11	9	5	1884	8	180	1739	546	188.00	47	81.67	CHANGED	hstMAhAut.uGAsGlRhpGVpslpthpshVslPIIGIlKRDhPssslhITshhp-lDpLAssGs-lIAhDuTsRsRP..lsl-shlcpIKcph..pLhMADCSohEEGlhspphGh-hlGoTLSGYTssp.s...s-PDapLl+sLspAGhh..VhAEGRhsTPE.Apcsh-hGssuVsVGuAlTR.ccIsphFspAlpp	...................................................................................................hutMAhAAppuGAVuI.......Rh........p...ul...p...s.lps.l.+p.h.V..s.lPIIGIlK......R.D.h.s...s....s..s.V..a.....IT.s.s...h.c....-VDtLsp.sGs.-lIAlDu..Tt.RpRP.......hslp.phlp...pI...+.c.+h..........hL.h..M......A.D.s.S.o....h...E..-....u..l....s....A...tc...h...G.hDh....l.........G...T..T..L......S..G.....Y.....T..s..sss.........ppP..D.....h.....p....L.....l....+...p....L....s....c....s......s..s......VIAEG.+hpTPppAtc.s.h.c.h.GAauV..VV..G.u..A..I.T...R...Pc...c..IsphFssAlc.......................................................	0	49	100	147
+3475	PF04660	Nanovirus_coat		Nanovirus coat protein	Waterfield DI, Finn RD	anon	Pfam-B_4486 (release 7.5)	Family	Family of conserved Nanoviral coat proteins [1].	25.00	25.00	143.60	143.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.99	0.71	-4.56	3	85	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	11	0	0	65	0	166.00	74	99.27	CHANGED	suRWshpGhK+RRosRRKYGRhAYKP..PoS+VVSHluSlLsK--VVGs.EIKP.DuDluRYpMhKVMLlsTL+MsPGELVNYlIVKSSSPIANWSouFosPuLhVKESsQDhVoIVuuGKLESuGsAG.oDVTKSFRKFl+LGuGISQTQHLYLlhYoSsAlKIsLEsRlYI-V	....huRas+puIKKRRVGRRKYGS.KA.....ATSHDYSSLGSILVPENTVKVFRIEPTDKTLPRYFIWKMFMLLVCKVKPGRILHWAMIKSSWEINQPTTCLEAPGLFIKPEHSHLVKLVCSGELEAGVATGTSDVECLLRKTTVLRKNVTEVDYLYLAFYCSSGVSINYQNRIhhcV.	0	0	0	0
+3476	PF00956	NAP	NAP_family; 	Nucleosome assembly protein (NAP)	Finn RD, Bateman A	anon	Pfam-B_1009 (release 3.0)	Family	NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity.  They affect the transcription of many genes.	26.90	26.90	27.30	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.60	0.70	-5.25	97	1619	2009-01-15 18:05:59	2003-04-07 12:59:11	13	20	399	31	836	1514	9	214.90	28	67.14	CHANGED	+..p+l.psLcplQtchppl-tcapcchhcL.Ep+YtphhpPlap+...RpcIlsG.h...tsp....................................................................................s.lP.sFWLssh.cNpshlu..phIs.-cDcphL.caLpDlchphhcs...............uFpl.FpFss...NsaFpNp..lLoKpYhhps.....p........................pspuspIcW+.pu+slThphhp+....................KpcpKtpt..th+.lpct..tc...........SFFNFFs......s.......p...........................t.t..ptpchp..t.ht.DaclGphl+-cllPcAlpaasGcs	................................................................................................................................tlttLctlQ..chsplptph.cchhp..........l.EpKatph.hp.Ph...ap+...Rp.pllps...........................................................................................................................................................................................................................................................................................................................................IP.sF.W.hss.......h..tN..ps.........lu...............thlp...-pDEth.L..caLpc.lclp..hct..........................uap.l.pFhFpt......N.sY.Fp.Np.............lL...s..K.pah..hpp.....psp............................................................tspuspIcW+..pGcs.lsh.ph.pp......................................................tp.ppptt................p..............................................SF.Fs.aFs........................................................................................................t..t..p.t.................s.cluphl+-clhPpsl.aah...............................................................................................	0	233	366	559
+3477	PF03892	NapB		Nitrate reductase cytochrome c-type subunit (NapB)	Bateman A	anon	COG3043	Family	The napB gene encodes a dihaem cytochrome c, the small subunit of a heterodimeric periplasmic nitrate reductase [1].	21.10	21.10	21.20	21.20	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.10	0.71	-4.48	75	1044	2012-10-01 23:37:15	2003-04-07 12:59:11	9	3	988	11	158	429	23	131.50	46	86.09	CHANGED	hhshsssussssssp.......................ltsLRsss.lssp.ssssshpph.....spcstphpRsYspQPPlIPHsl-u...YplshssN+CLoCHuhppspcstAshlSsTHahD..R-GphL.uslSPRRYFCsQCHVPQsDu.pPLVpNsFpsh	..............................hhs.hsshstssts.................................................t.s....sst.-..shh+h.......P+Epp+hshsYVNQPPhIPHSl-G...YQ.VTpNsN+CL.pCHuh.....-....s....h+s...o.GAs+ISsTHF.h.D....p..................DGK..Vs...upVuPRRYFCLQCHVPQuDs.tPlVsNoFpP.s....................	0	28	80	125
+3478	PF03927	NapD		NapD protein	Bateman A	anon	COG3062	Family	Uncharacterized protein involved in formation of periplasmic nitrate reductase.	28.00	28.00	28.20	28.20	26.40	27.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.32	0.72	-4.15	59	1029	2012-10-02 00:20:33	2003-04-07 12:59:11	8	1	992	2	164	424	22	78.70	39	82.85	CHANGED	pch.HIsSLlVpspPcclspVpssltslsssEIauhssp.GKlVVllEusspttlhcplspIpslsGVLssuLVYHp...h-st	......p.phplsSLVVpA.Ks.-.+.l.sslpspLsshPus.Eltss....-s..Gp.....LIV.VlEu-sp....-sllpoIEu.lcslcGVLuluLVYHQQ-p.............	0	34	85	130
+3479	PF03059	NAS		Nicotianamine synthase protein	Mifsud W	anon	Pfam-B_2173 (release 6.4)	Family	Nicotianamine synthase EC:2.5.1.43 catalyses the trimerisation of S-adenosylmethionine to yield one molecule of nicotianamine. Nicotianamine has an important role in plant iron uptake mechanisms.  Plants adopt two strategies (termed I and II) of iron acquisition.  Strategy I is adopted by all higher plants except graminaceous plants, which adopt strategy II [1,2]. In strategy I plants, the role of nicotianamine is not fully determined: possible roles include the formation of more stable complexes with ferrous than with ferric ion, which might serve as a sensor of the physiological status of iron within a plant, or which might be involved in the transport of iron [1]. In strategy II (graminaceous) plants, nicotianamine is the key intermediate (and nicotianamine synthase the key enzyme) in the synthesis of the mugineic family (the only known family in plants) of phytosiderophores. Phytosiderophores are iron chelators whose secretion by the roots is greatly increased in instances of iron deficiency [2]. The 3D structures of five example NAS from Methanothermobacter thermautotrophicus reveal the monomer to consist of a five-helical bundle N-terminal domain on top of a classic Rossmann fold C-terminal domain. The N-terminal domain is unique to the NAS family, whereas the C-terminal domain is homologous to the class I family of SAM-dependent methyltransferases. An active site is created at the interface of the two domains, at the rim of a large cavity that corresponds to the nucleotide binding site such as is found in other proteins adopting a Rossmann fold [3].	23.80	23.80	23.90	23.80	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.86	0.70	-5.24	13	220	2012-10-10 17:06:42	2003-04-07 12:59:11	11	2	133	12	98	214	3	240.50	29	85.46	CHANGED	spN...ssslVcKIssLYstIS+LsSLs....PSscVssLFTcLVssClPssP.lDVoK..Ls..clQchRspLI+LCupAEGhLEuHaSshLuua-.NPLsHLshFPYasNYl+Lo+LEaslLupasst.sPs.+lAFIGSGPLPLTSlVLA.....opHLs.....................sTsFcNaDhsusANspAppLls.uDssL.usRMsFHTuDlsclss-LssYDVVFLAALVGMspE-KsKllsHLu++MAsGAsLllR.SAHGA.....RuFLYPllDPp.Dlp..GF-VLulaHPs.D-VlNSVIlARKhh.ss	...............................................................................................tt........hltplhth.ttlt..pL.s.t......p...p......pth...Ft...pL...hs.....p....ch.p.....Lt...phpthhtplhplps.ApuhLEtahu.p....l...s...uh..p......s........P....p..p.......l.p...F...sYassY.pLsphEhphhsh..thst..........st..+VhFlGSGPLPhoullLs.....tph.hs....................................sshh.shDh-ssA....tphAp.pLlp...s...s......L........p.pphp.Fhsss...h.t.p............h..s..p..s.lt.taDhlhlA.uLVu.......pKtplltpLtphhs.......s.....uu..hLlhR...supGh.....Ru.hL.Y..s...lc.t...pht...saphhs.h.P...........h.so.hh........s......................................	0	27	56	80
+3480	PF04159	NB		NB glycoprotein	Bateman A	anon	Pfam-B_1501 (release 7.3)	Family	The NB glycoprotein is found in Influenza type B virus.  Its function is unknown.	24.40	24.40	24.70	80.70	21.60	24.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.43	0.72	-4.27	24	1614	2009-09-10 20:28:57	2003-04-07 12:59:11	8	2	1536	0	0	543	0	95.00	93	99.71	CHANGED	MNNATFNYTNVNPISHIRGSVIITICVSFTVILTVFGYIAKIFTNKNNCTNNsIGL+ERIKCSGCEPFCNKRDDISSPRTGVDIPSFILPGLNLSESTPN	....ATFNYTNVNPISHIRGSlIITICVSFIVILTIFGYIAKIhTNRNNCTNNAIGLCKRIKCSGCEPFCNKRGDTS.SPRTGVDIPuFILPGLNLSESTPN.............	0	0	0	0
+3481	PF00931	NB-ARC		NB-ARC domain	Bateman A	anon	[1]	Domain	\N	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.75	0.70	-5.55	12	16257	2012-10-05 12:31:08	2003-04-07 12:59:11	17	1033	906	35	4750	16655	176	210.80	21	35.74	CHANGED	hcs.l-plhp+Lhp.p...pphtllulhGMGGlGKTTLAppla.pc.p.lpppF.DhhhWlsVScphst....hclhcs..lhpcLt.ss..h..........................spcs.sp.httclpchLppK..RaLllLDDVWcc...pa-plt.shsstp.ts+lllTTRspsVstthss..sphhplp.hLp.-cuWpLFppc.....shcpp..........tpsplE-lu+plspcCpGLPLulpslGuhhtpKp.pl.pEWcchhcp.hppphht..p......splhs.hlthSYcsLst.pLKpCFlhhu.......hFPcshphttcplhchWhspshl.sps.	.....................................................................................................................................................................................................u..G..l..GK.TT.......l....A...........p.....t....l........h....p.......p.........................h.......p.........p.....p.........F........p.....h.....h.....h......a.....l............s.....s.....s....p....p..h.sh.................hpl...pp.......l...h...p...p..l.....t..h.p.......................................................................................t...s.....pp.....hh....ph....l....p......p.....h.....L.......p.......p....+...........+.............h...L......l....l....L....D............D.........l...............p.p...................ph.........p...........t...............l...........t......t..................h.....................................h........s..............................G...........o............+.........l...l..l...T......T..................R.........p.........p.........p.........l..............h......t...........h.........h........t......................................t........t..............h.......h.....p....l........p............L................s............p....p...........c.....u....h....p....L.....Fp..pp.......................................s.h..tpp.................................p.h............p.....l...u.......p.......p...l...s..p..h.......s...t...G.......l..P.L.Al...................h....s..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	726	2813	3845
+3482	PF04485	NblA	nblA; 	Phycobilisome degradation protein nblA 	Kerrison ND	anon	DOMO:DM04316;	Family	In the cyanobacterium Synechococcus PCC 7942 (Swiss:P35087) , nblA triggers degradation of light-harvesting phycobiliproteins in response to  deprivation nutrients including nitrogen, phosphorus and sulphur.  The  mechanism of nblA function is not known, but it has been hypothesised that nblA may act by disrupting phycobilisome structure, activating a protease or tagging phycobiliproteins for proteolysis. Members of this family have also been identified in the chloroplasts of some red algae.	25.00	25.00	27.10	27.00	23.20	20.70	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.41	0.72	-4.10	14	86	2009-09-10 15:48:25	2003-04-07 12:59:11	7	1	55	22	26	74	5	52.30	38	84.84	CHANGED	s.sLoLEQcFpLphappplpplshEQspchLl-hh+QhMl+-Nll+tllKpuh	....pLSLEQpFpLpshpppVpphSpEQAp-aLlchhcQhMl+-Nhh+pLlKpp.....	0	3	18	26
+3483	PF03801	Ndc80_HEC		HEC/Ndc80p family	Bateman A	anon	[1]	Family	Members of this family are components of the mitotic spindle.  It has been shown that Ndc80/HEC from yeast is part of a complex called the Ndc80p complex [1]. This complex is thought to bind to the microtubules of the spindle.	20.50	20.50	20.70	20.50	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.88	0.71	-4.80	37	358	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	283	5	242	368	4	153.10	29	25.72	CHANGED	stpc+oshht........sRsShs....shtspps............+DPRPL....+D+saQsphhpplhcaLsppsa....spslo.+sLpsPopK.-FhtlFpaLYpp.lDPsaca...tp.ph-pEl.plLKpLpYPa..sIoKSplsAlGusp.WPphLuhLpWLhpLsphhsphhsp.......Dpshtspth	............................................................................s..................R.S.h.......s...t.tp...................pDsRPl.........pD+saptphhpplhcaLspp.sa............ttsl.o.....p..sl.ps.....PotK.-F.hlFpaLapp...l-.Psaph.......................pp.ph.--E.ls..lLK.pLpYPa..sloKSpltAsGusptWPphLuhLpWLhclsp.hhpthhppp.............ss.t......................	0	82	134	203
+3484	PF00334	NDK		Nucleoside diphosphate kinase	Finn RD	anon	Prosite	Domain	\N	21.60	21.60	21.80	21.80	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.50	0.71	-4.37	171	5820	2009-09-13 01:46:53	2003-04-07 12:59:11	14	37	4319	479	1940	4004	2188	131.60	43	80.92	CHANGED	E..RThsllKPDuVpRs...LlGcIlsRh.Ecc.Gh+lluhKh.hplocchAcp..aY.....scHps.+P....FFssLlpahoS.....G.P....llshVlEG....c.sulptsRplh....GsT.sPtc.A...tPGTIR...u.DFuhsh........sc...NslHGSDSsE..oAp+EIshaFs...tpEl	.....................................................................E+ThslIKPD..u.V..p..+.s.............l.l.G.c.I.l.s.Rh.Epp..Ghcll.u.h..K..............h.h..............p.l..o.c-.p...Ac...p...aY................................u-.....H....ps...+P................F..Fs..s..L.l..c.F.MoS.................G..P.......l.l.s..h.............Vl...EG..............cs..Al.pp...hRplh.......G....uT..sPtc.A......................tsG.....TI..R...u..Dauhsh................sc........NslHG..S.DS..E..o..Ap+EIshaFst.............................................................................	0	667	1125	1540
+3485	PF05031	NEAT		Iron Transport-associated domain 	Yeats C	anon	[1]	Domain	This domain is involved in the transport of iron, possibly as a siderophore.	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.50	0.71	-4.11	53	2305	2009-01-15 18:05:59	2003-04-07 12:59:11	7	72	393	47	143	1431	4	121.10	25	39.58	CHANGED	ssspltcGpYslsaplhKcss....s-tShhssYhpcPuplplcsGKphlplTlss..o.....sahpshplp....sGp...........hhcscll...Scsp........tps.s+s.lcFc.Vsslspclssphplhl.....h...sYctpaplphthDsss	.....................s..pt.tssphslsapl.hKs...ps.....spp.S.hh..s.sah.p.cPuplhh.p.s..GK.hh.lp.h.slps...u......................sahpcaplp...tsst.............................thss.cll........ScDp...................pps...s+s..lpFt..Vs....s......hsppls.shlcl.l.....sp...h....sYcapYslph.hp...................................................	0	46	94	107
+3486	PF00880	Nebulin	Nebulin_repeat; 	Nebulin repeat	Bateman A	anon	Pfam-B_1603 (release 3.0)	Repeat	\N	20.10	20.10	20.20	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.86	0.73	-7.23	0.73	-4.11	143	8841	2009-01-15 18:05:59	2003-04-07 12:59:11	13	120	100	0	4092	7213	2	28.70	29	38.71	CHANGED	DsPphhpA+pssphhS-hpYKcsaccp+s	.....DsPchhpA+pstchhS....-..hpYKcsa-ct+........	0	255	486	1390
+3487	PF04299	FMN_bind_2	DUF449; Neg_reg; 	Putative FMN-binding domain	Kerrison ND, Bateman A	anon	COG2808	Family	In Bacillus subtilis, family member Swiss:P21341 (PAI 2/ORF-2) was found to be essential for growth [1]. The SUPERFAMILY database finds that this domain is related to FMN-binding domains, suggesting this protein is also FMN-binding.	20.70	20.70	20.70	21.20	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.14	0.71	-4.76	129	884	2012-10-02 11:35:36	2003-04-07 12:59:11	7	4	757	2	337	872	133	165.30	34	77.90	CHANGED	MYlPstFp..ts-hstltphlcppshuhLl..............o.t....ssss...l.AoHlPhlLc...tt..........sspshLh..uHlARuNPph...ppl................ptss.p..lLllFpGP.cuYlSPsWY.....ps.tcsVPTWNYtuVHsaGphplhp...Dsc......hltphlscLospaEssh.........tpPWp...hs-sssc..alcthl+uIVGhclpIscl	............................MYlPttFt...sc.ptltph.lpppshusLl.....................o.p...ssss.......Ao.HlP..hhLs.....t.........................tsspshLpuHlARsNPpappl................................ptsp..c....VLllFpG....s....cuY...ISPsWY...............ps.....tc.....t.....VP.TWNY.huVHsaGp.hplhp.Dpp............hltshlscLoppaEssh......................tsPWphs-ssts..alcthh+uIVGhcIplscl.............................	1	89	193	279
+3488	PF00960	Neocarzinostat		Neocarzinostatin family	Bateman A	anon	Sarah Teichmann	Domain	\N	25.00	25.00	27.70	27.20	22.60	23.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.04	0.72	-10.55	0.72	-4.13	4	25	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	19	25	6	38	1	109.60	34	72.85	CHANGED	usoVoPAoGLSDGpoVoVSuoGhssGTsYpluQCAhVssGhhACNsAshoshTsDAsGpuosSlsVR+SFpGhlhs.GT.hGoVDCsTs..uCplGlGssuG-hup.sAIoFu	...........sloVoPuoGLoDGpoVoVouoGhssG.oshtluQC..As..ls..s..GthACssAsssssT.sDAsGss.osolsVR+SFsu.shs.Gsth.uoVDCs.Ts..uCtlusus...susssut.ssloF.....................................	0	4	6	6
+3489	PF03391	Nepo_coat		Nepovirus coat protein, central domain	Mifsud W	anon	Pfam-B_3589 (release 6.6)	Domain	The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure [1].	20.30	20.30	20.50	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.72	0.71	-4.99	11	339	2012-10-04 01:49:40	2003-04-07 12:59:11	10	7	28	141	0	391	1	168.10	69	25.28	CHANGED	PslsaPhps.tchphhhlhhPPhphsluussuhposshhhupshhsusppsYsasssLlSaaLGhGGol+GcV+psuosFhossLhVs.pWtGsosshppLhphPtshlct.DGphplcIpSPaacTss.hh-ututh.lss......luGPlAPpspsuphtahlpIcpIst..s	........................................PTLVFDPGV.FsGKFQFLTCPPIFFDLTAVTAL+SAGLTLG.Q..VPMVG.TTKVYNLNSTLVSCVLGMGGTIRG+VHICAPIFYSIVLW..VVSEW.N..GT.T..MD.WNELFKYPGVYVE...E...DGSFEVKIRSPYHRTPA..R...LLAGQSQRDMSSLN.FYAIAGPIAPSGETARLPIVVQIDEIVR..P.................................	0	0	0	0
+3490	PF03688	Nepo_coat_C		Nepovirus coat protein, C-terminal domain	Mifsud W	anon	Pfam-B_3589 (release 6.6)	Domain	The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure [1].	21.10	21.10	21.90	23.80	20.40	21.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.79	0.71	-4.61	21	412	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	28	141	0	397	0	149.10	66	26.03	CHANGED	hshsphF.sWhsl...sshpsss....hphpIPuRltDls........spsssVshtsNPhuhhhussGhHtGp.lpL+hpWsh.psphuptpGslthhphhtchupshsspstl......ssh.ssuhph.lphGsFuGssssu..shshhsc..altlphspucplppLpVslclhsGFpFYGRo	..SF..EDDYF.VWVDF...SEFTLDK....EEIEIGSRFFDFT........SsTCRVSMGENPFAAMIACHGLHSGl.LDLKhQWSL.NTEFGKSSGSVTITKLVGDKAhGLDGPSQl......FAlQ+LEGss-LLlGNFAGANPNo..HhSLYSR..WMAIKLDQAKSIKlLRVLCKPRPGFSFYGRT........	0	0	0	0
+3491	PF03689	Nepo_coat_N		Nepovirus coat protein, N-terminal domain	Mifsud W	anon	Pfam-B_3589 (release 6.6)	Domain	The members of this family are derived from nepoviruses. Together with comoviruses and picornaviruses, nepoviruses are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. This family aligns several nepovirus coat protein sequences. In several cases, this is found at the C-terminus of the RNA2-encoded viral polyprotein. The coat protein consists of three trapezoid-shaped beta-barrel domains, and forms a pseudo T = 3 icosahedral capsid structure [1].	27.30	27.30	27.60	28.80	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.56	0.72	-4.26	21	379	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	32	141	0	386	0	87.90	68	12.85	CHANGED	hsaspslplPp-sptGslLuplslhsthpshsuhsatcWlppG..hlpsplclhh+lssssFsGlolhhsaDAasRl.s.sshssshshshshsl	...LAGRGVlYIPKDCQANRYLGTLNIRDMISDFKGVQYEKWITAG..LVMPpFKIVlRLPANAFTGLTWVMSFDAYNRI.T.SRITsSADPlYTLS.V.........	0	0	0	0
+3492	PF00064	Neur	neur; 	Neuraminidase	Eddy SR	anon	Overington and HMM_iterative_training	Family	Neuraminidases cleave sialic acid residues from glycoproteins. Belong to the sialidase family - but this alignment does not generalise to the other sialidases. Structure is a 6-sheet beta propeller.	19.60	19.60	19.80	19.60	18.90	19.30	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.77	0.70	-6.40	7	29236	2012-10-02 00:45:24	2003-04-07 12:59:11	13	4	28530	235	0	16025	0	436.40	57	99.38	CHANGED	MNPNQKIlsluulululsllslLlpluslhlsls.hh+ttt....pps.ssps..p..Npslptpshsp.sshshhhs....ppspahs.sculCslpGashhuKDNuIRlGpp...uplhVhREPaVSCsPsEC+pFhLoQGshlssKHSNGTl+DRosaRsLhSs.LGpsPslhpo+FcsluWSuouCHDG+tWhsIsloGsDssAsAslhYsth.T-sIpSWu+sILRTQESpCVClsGsChhVMTDGsAsspAph+IhhhccG+Il+pp.lousupHlEECSC.YsppspVpCVCRDNWpGuNRPllpls.p.hsapstYlCoGlhsDTPRspDsshossCs.Ns.ssps....GVKGFuacpGss....sWhGRTISpsSRSGaEhlhl.sGhopssS.p.hp+QslVsspsWSGYSGuFh.hst.st.pChsPCFaVEhIRG+Pc.EppshWTSsS.lshCGsssphssWSWsDGAplsa	....................................MNPNQKII.TIGSlshsIuhlslhlQIu.llohhs...H.hQht....spsp......p..p..s........s........s...h....p...p..sh...s...p.......s...Y..ls...ss..hph.hs....hhu..hh.shsps.CsloGaA.aSKDNSIRlGup...GDlaVhREPalSCush-C+pFhLoQGshLNsKHSNGTl+DRoPYRTLhSs.lGpsPsshNo+hcslAWSuSuCHDGhuWLpIsloGPDssAsAslhYNGhlTDoIpSWpps.ILRTQESECsClNGoChsVMTDGsu.sGpAs.h.K..Ih+I.EcGKIVKospL.s.usshHhEECSC.YPc.tsplpCVCRDNW+GSNRPh.VshN.s.hphphuYlCSGlhGDsPRPNDuouSsssh.sPssppG..u.GVKGauF+.GNs....VWhGRThSpsSRsGaEhhhs.sGW.os.ssS.s.sh+QsIVshssWSGYSGuF..asp.st.sCIpPCFaVELIRGRP.c.E..pslWTSsS...lsFCGssushsshSWPDGA-lsh...............	1	0	0	0
+3493	PF02932	Neur_chan_memb		Neurotransmitter-gated ion-channel transmembrane region	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family includes the four transmembrane helices that form the ion channel.	23.10	23.10	23.20	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.56	0.70	-4.48	50	6256	2009-12-16 13:54:54	2003-04-07 12:59:11	11	81	288	162	3294	5277	71	169.90	20	43.13	CHANGED	lllPClLIohLohLsFaLPsDuG.pKsoLuIosLLohTsFhlllscplP.poShslPLlspYllhhhhlssh.lhhsllllNsphRsP.psHphsphl+phhl.phlPphh.....hhppsstshssspstptttstsh.h.................................................................................................................................................................sststtstsssssss.hphssplcpulpus...............paIupp....................................................................................h+pcsp..p.tpsWhhsutslDRlthhlFslshllsolsha	.................................................................................................................................................hhlPshhlsh..l..o....hl.s........Fa....l........s............c..u...s.................t+h.s...L...............u...............lo..s.l......Loho.s.....h...hh........hp..p.tlP......t..s......S......h..s...........h........s....l...........................h..h...............h.h..........h..........h..h..hh...l..hs......h.......l..................h.s..h.l.s.....h.............h....p..h...p....t.............t........h............h..............t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	922	1195	2303
+3494	PF02158	Neuregulin		Neuregulin family	Mian N, Bateman A	anon	IPR002154	Family	\N	20.30	20.30	24.60	22.80	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.50	0.70	-5.69	2	267	2009-09-11 01:37:10	2003-04-07 12:59:11	10	8	42	4	77	244	0	313.30	50	58.48	CHANGED	AEELYQKRVLTITGICIsLLVVG.MCVV.AYCKTKKQRpKLpDRLRQSLRpcppNlsNhsNtPHpP.NPPP.cNVQLVNQYVSKNVISSEHllEREsETSFSTSHYTSTsHHSTTVTQTPSHSWSNGhoEShIS.cS.SVIhhSSVENSRHoSPsG.PRGRLpGlGG..c.sSaLRHAR-TPDSYRDSPHSERYVSAMTTPARMSPV-F+TP.SPKSPs.EhSPP.SShsVShPSVAVSPFlEEERPLLLVoPPRLREK+YD+........pQhNSaHHNPuHpSoSLPPsPLRIVEDEEYETTQEYEss.EPsKKlsNSRRtKRTKPNGHIuNRLEhDSsoSS.SSsSESETEDERlGE-TPFLuIQNPLAASLEsAshaRhA-SRTNPsuRFSTQEELQARLSS	.......................AEELYQKRVLTITGIClALLVVGIhCVV.AYCKT....KKQ.RK...phHs+LRQs..hpsc+.pN.hhslANG..P..pHP.tsPs.E..plQhs.sp.YlSKNl...uo-Hllc+EsET..o..FSsSH.sSsu.HHso.TsTpT.s.....S...........H.......o.......WS.t+oESlhS.-SpS.slhhSSVtsS+psSPss..sRuR...hs...u...hsu.......c....c....ps..hh....th+-o.DShRDSP.HS..ERYVSA...hTTPARhS.......P.V-Fchs.....sspsPs.phosP.uuh.shS.hPshs.hs.h.h.t-pp..PLl..h..................................................ts.......................................................s.S.Pso.Ph+l..--..ph-sh......pph.ss.................p..........t......p...t+sp.sG.hu.c........sp.t..u.s.s.............o.........s-t-.-t...........uEsTPFLuhps............sh........tsRT........................................................................................................................................................................	0	2	9	27
+3495	PF03823	Neurokinin_B		Neurokinin B	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	28.00	35.90	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.91	0.72	-4.22	3	39	2009-09-10 23:24:23	2003-04-07 12:59:11	9	2	26	0	16	39	0	54.90	63	37.49	CHANGED	MRSsLLFAAILALSLApSFGAVCEEPQEQVVPGGGRSKKDSDLYQLPPSLLRRLYDSRs	......MR.hLLFsAILAhSLApSFGAVCcEsQEpssPGGG+SK.+DsDLYQLs..sl..LRRLacS+S..................	0	1	1	4
+3496	PF00243	NGF		Nerve growth factor family	Finn RD	anon	Prosite	Domain	\N	21.30	21.30	21.30	21.70	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.57	0.71	-4.36	7	3765	2012-10-02 16:54:34	2003-04-07 12:59:11	13	4	2066	24	107	2860	0	90.40	67	44.04	CHANGED	psht+RGEhSVCDSlSlWVT..-KpoAsDl+G+pVTVLs-Vshssus.hKQYFFET+C+ss.......sssssGCRGIDp+HWNSpCpsopoaVRALTh-spp.VuWRaIRIDTACVCsLopKoGp	.............................p-..su+RGEhSVCDShSc..WVT...-Kp.TAVDhpG.tpVTVLtcV...sls.put.lKQYFYETKCpsh..........................t....s.K.pG.CR.GIDt+a.WN.S.CpTopo....aV+AL..T.-tp.............................................................	0	12	21	45
+3497	PF02979	NHase_alpha		Nitrile hydratase, alpha chain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	27.20	27.20	27.20	27.20	25.90	27.10	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.23	0.71	-5.02	37	386	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	295	57	122	382	231	157.00	41	86.98	CHANGED	sp.o-hthRspALEplLhEKGllssusl-thl-haEschGPpNGA+VVA+AWsDPsF+ttLLpDuoAAhtEl....GasGtp..G.........EahlsVENTsplHNllVCTLCSCYPWPlLGLPPsWYKossYRuRsV+-PRsVLt.EFGlsLPsssclRVWDSoAEhRYlVlPhRPsGTEGhoE-pLAsLVTRDoMIGsuls	...................p.....t.h.hAL.phL.tKGllsst.lcthhphh-pp.u.PttGAclVA+AWsDPsF+thLLtDusuAh.tp.h.....Ghts.p.G......................phhhslEsTsph+NllVCoLCSChsWslLG.LPPsWYKs.tYRuRhV+-PRtVLs.E.hGhplsscsclRVaDooA-hRYhVlP.RPsG.T-.shsp-tLttlVo+-shIGsu.........................	0	38	69	88
+3498	PF02211	NHase_beta		Nitrile hydratase beta subunit	Bateman A	anon	Pfam-B_5347 (release 5.2)	Domain	Nitrile hydratases EC:4.2.1.84 are unusual metalloenzymes that catalyse the hydration of nitriles to their corresponding amides. They are used as biocatalysts in acrylamide production, one of the few commercial scale bioprocesses, as well as in environmental remediation for the removal of nitriles from waste streams. Nitrile hydratases are composed of two subunits, alpha and beta, and they contain one iron atom per alpha beta unit [1]. 	21.30	21.30	21.70	21.70	19.80	21.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.69	0.70	-4.64	33	440	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	230	80	156	463	350	165.30	25	93.48	CHANGED	MsGsHDlGGhpGh.GPV..s.-....s.--PlF+t-WE+RAhulphAhsu..hGt.....................WslDpsRaAtEphsPs-Y...lpsoYYc+WltulppLhl-pGhlop-ELst.......uphhpsstshsp.slsA...-tVsshLtcGsPspR.sssssspFtlGDpVRs+.shsss.....uHTRLPpYlRG+sGplt.thaGsaVaPDosA.cGtGEs.PpaLYsVtFsupELWGss.ssssssVslDlWEsYL-sA	..................................................l....p........t..tts..sFpt.WEtpsaulhhshtt..hGh.....................ash....--......h......R.......h..........u....h.......E....p.....ht.....s.....t.pa.......h.t.hsYYc+WltulppllsccGllotpELtth...........t.....st.....................................................................p.l.h..............a.Rh..ah.th.G.l................................h.l......................................................................................	0	31	80	108
+3499	PF01292	Ni_hydr_CYTB		Prokaryotic cytochrome b561	Finn RD, Bateman A	anon	Prosite	Family	This family includes cytochrome b561 and related proteins, in addition to the nickel-dependent hydrogenases b-type cytochrome subunit.  Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently.  This is a  prokaryotic family.  Members of the 'eukaryotic cytochrome b561' family can be found in Pfam: PF03188.	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.42	0.71	-4.89	84	1155	2012-10-03 10:28:09	2003-04-07 12:59:11	15	11	975	0	237	5046	1484	182.50	26	73.89	CHANGED	ta..shhhR...........hhHWhhAlhhlhhhh...oGhhhhhh..hhhhh...................................................................hph....Hhh..hGhshhslh.lh+lhht.....................................hptphPthhttsshtph...................hhhhlhhhhhhhsloGhhh.............................................stshtphhthlH..hhuhhlh.shlhlH.lhtslhpphh.t...slppMhsG	.............................................................................h.ashhsRlhHWssAlhhllLlh....oG.lh...h....s.h.h...s.h.s.h.st.h....................................................................hsl..........Hth...hGahLluhh..hhhll.thh..............................t.hhth..s.h.......t...t...h.t...p..h...h....h.h...h......h...t..l..h..p.....s..c..........t.....s...h....s....u...t..s.sph.....................hhh.l.h.as.L.l.sllllTGllhhh......................s.....h....................................hs.uh..t..h..h..hth.....H..hhlAhlhl..halhsH.l.h..hs.h.hs..ph.t...p.......hhcuMlsG...........................................	0	56	139	181
+3500	PF04097	Nic96	NIC;	Nup93/Nic96	Wood V, Finn RD	anon	Pfam-B_5541 (release 7.3);	Family	Nup93/Nic96 is a component of the nuclear pore complex.  It is required for the correct assembly of the nuclear pore complex [1].  In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1 [3]. The structure of Nic96 has revealed a mostly alpha helical structure [4].	19.10	19.10	19.70	19.50	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	613	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-13.15	0.70	-6.39	40	382	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	274	4	256	382	2	536.10	25	67.14	CHANGED	s.plh-tapths..............................sshcscpls-hWphlpphh.....................shpusshptpllpsu+paLEppahpalpshlt+s.pcAthtGhPsshs+lpualch+ltpts......sLt...l...supPlWsllaYhLRsGhhppAhchl....tpthpphcpsFhsahpsaspstsppLsschps+lptEasppl+ss.t............DPYKhAlYplI.....G+CDl....spp...shs.plspolEDaLWl+Lsll+pss.t.sps.......h-pasLs-lQshlh.paGpppFss......stps.hYaplLlLoG.FEtAlpaLhc.....hspsDAVHhAIuLs.huLLpsust.p.........pplLshssps......lNauRLlspYs+.pFchsDsptAlpYhhhlshhps...............ppth.shhpcslp-L.....lL-oR..-FshLLG.clpp.cGp+..hsGll-c.........lhthps.cp.hpplsppsApc..s-ccGphp-AlhLYpLup..............paDpVlsllN+hLupslspsst......................................stospsslhthApplhchYpsssth..p..lpspscpT.hplLlplhphhshappspappALptlppLs.llP.............ss.sp..lcctuppFps..lssplh+slPslLlhsMssltphhpplpssthss.tp................ppplspL+ppA+slh..haAuhlpY+hP	.......................................................................................................t...hhthhtth...............................tthp.ppp..hschWhhhpth.......................................shpshphphphlptuppaLEppahpahpshlhts.ppAthGG......hPsshp.......hl+ualpl+h.t.t..........tht....s....................pspslWsllaYhlRsG.hptAhphl...........pth..pp.....tpF..hshhppa.........hp...........s..................sppl...s..php..pp.lp.capptl+pss.........................DPa+hAlYpll.........GpCDh........sppp....tls.pshEDal....Whp...L....s.lp.ssts.p.s....................p.hsLtplQp.lh.ph.Gt..phFst.........ttp.hhah.lLhLsu.FEtAltaLhp.....h..scAVHhAlsLt.htLLthsst.p.................tthlshpstp.........................lN..hspllh.Ysp.pF.c..ssspt...AlpYhhhlp..ts...............................pt..phhhpslp-l.....llc..o+...pashllG..chp...cGp+.........h.Ghl-p......hts...t.hpplh.psAp...spppGh..hp-AlhLYpLAt.................................................ph.-pslplhsphL.upslst..t......................................s.sttpp.h.hAtphhphaptps...h........................hpt..pps...hhlLlplhphhs.hpst..p....h.tpA..l...c.lppLp.llP.............hs.tp....lcptsttaps..hsstltpslspllhhshphl.p.hp.phttst.ts..t.................pt.hppl+p.upslh...auu.l.a+h.............................................................................................	0	88	139	216
+3501	PF03824	NicO		High-affinity nickel-transport protein	Griffiths-Jones SR, Kerrison ND, Finn RD, Eberhardt R	anon	Manual	Family	High affinity nickel transporters involved in the incorporation of nickel into H2-uptake hydrogenase [2] and urease [3] enzymes. Essential for the expression of catalytically active hydrogenase and urease. Ion uptake is dependent on proton motive force.  HoxN in Alcaligenes eutrophus is thought to be an integral membrane protein with seven transmembrane helices [4]. The family also includes a cobalt transporter.	25.00	25.00	25.00	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.72	0.70	-5.09	20	2471	2012-10-02 18:22:22	2003-04-07 12:59:11	11	9	1720	0	612	1814	250	244.40	22	78.85	CHANGED	hhuhshLuashGlhHAh-.ssHhtAl...lpshhtsscssltsGhhhohupSslhslhulhlshushhltp.....hsthpphsuslth.lsusFlllluhhshhlhpslhchatt..t....stt.tsthpthhtt.....................................t.hs+hht.......h+.h.tpphHhhssG...u.G..susphthhu.sst...th.shshhshhsasslFuuGhp.ssuu.sllhhuhhshsahs..hhthhasholsGsulsluhhsshlhshphlAp+hshpss...hstlstls...hphlGhhllhlhulshlsuhlh	............................................................h.hhhhhhuahh....G....lhHAl.s.s.sHhtsl................ht.phh......h...........s..t...........c.....s.s.l...t..........uhh....hu....lutohhh..shhs.lhl..sh..sshhltp.................thp.thsu.t.h.hht...l......s.shll...llu.h..s..h.h.h.h.......ps.hh.p..hth.htt...............t.t...h..p.th.h.................................................................................................t.h.........................t.....h...p...c..ph+..h...h......h...u...............t...........p....s.sph.th...h.s.s.t........th............sh.s...h.....h....h.h...h....hhhssGh..h.sssh.sllh.h.sh...h...h......shsh....hht...hhhshsl.hs...hh.l..shhhshh...h.p........hs.t..+.h..s.h.ts....hhp..hhshhs.............hhGhhhlhhhh.hshhh....h...................................................................................................	0	143	336	484
+3502	PF00374	NiFeSe_Hases		Nickel-dependent hydrogenase	Finn RD	anon	Prosite	Domain	\N	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.84	0.70	-5.73	12	4820	2009-09-12 07:59:36	2003-04-07 12:59:11	14	9	1571	65	1336	3444	238	268.90	27	63.43	CHANGED	RGLEhILKGRDPRDA.tFspRICGVCThsHALASVRAV-sAlGIclPpNAphIRNLhhtuhhlHDHlVHFYHLpALDWVslssALpADPttsucLspslS.shsh.oss.h..csVQs+lKcFVESGQLG.FtNuYas..p.AYhLPPEssLhAsuHYLEAL-hQ+chschhuIFGGKNPHs.shlVGGss.sh.slDs..........cRL.s.hpuhhcclp-FlcpVYlPDllsluuhYKc..hhhtGGhs.pNhLu....aG-aPps.....hstsohhhPsGslhsushscVhsl....D.t..c...EaVpHSWYc.ss-.huhHPa-GhT-Ppashhs.................D-s.+YSWlKAPRa+G+shEVGPLAphlluhup....uc......pthcc.l-hhltths......lssstlaST..............LGRTsARulEsthssp.ht.hhccLhsNlpsGc.sss.sccW-.sphPppu+GVGhs-APRGuLuHWl+IKDGKI-NYQsVVPoTWNuuPRsspGplGshEtuLlsT.hscPcpPlEILRTlHSFDPClACusH	......................................................................................................................................................................................................................................................................................................RGhEh.lhpsR.....s.h.s.s.h.hh.spRlCGlCshsHshu.shuhE.....s.....A..h.....s......l...p......l.....P.......p......A.phlRslh...t.s.hhpsHhl...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	448	910	1161
+3503	PF04891	NifQ		NifQ	Kerrison ND	anon	Pfam-B_6173 (release 7.6)	Family	NifQ is involved in early stages of the biosynthesis of the iron-molybdenum cofactor (FeMo-co) [1], which is an integral part of the active site of dinitrogenase [2].  The conserved C-terminal cysteine residues may be  involved in metal binding [1].	19.40	19.40	19.50	19.50	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.37	0.71	-4.09	39	166	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	159	0	76	167	16	160.20	35	80.39	CHANGED	cshAsl..Luhuhtptt.tt.usls.hh.GLsssshssLls+aFP........s..thtsh.....sshsss.spE.spLpsLLhsc.....pusssstuthlAtllAptshtssHLWpDLGLtsRsELStLlt+aFPsLAutNspsM+WKKFFYRpLC.-p-GhhhC.puPsCstCsDastCFG	.....................................................h....thLuthhttht.t.stssl.s..t.h.GLsssphttLlsph.FP............................t..sthh..h..........sth.ssstspEhtpLtsLLhtp..............tuss..sststhlAtllActshtssHLWpDLGLtsRs-LotLht+aFPsLAspNsp.sM+WKKFhY+plC.cpcGhhlCpuPsCstCsDashCFG..............	1	20	43	57
+3504	PF01106	NifU	NifU; NifU-like; 	NifU-like domain	Finn RD, Bateman A	anon	Pfam-B_1206 (release 3.0)	Family	This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown [1].	20.90	20.90	21.00	21.60	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.17	0.72	-4.20	20	3818	2012-10-01 19:25:19	2003-04-07 12:59:11	12	19	2999	6	1182	2450	2182	69.10	37	38.36	CHANGED	lpcVl-c.lRPhLhtDGGDlELlcV-Gs....pVpVcLpGACuuCspSshTLpsulEp+Lp-pls.pslcVlsl	..................lctlL-p..lRPhLt.t.DGGc..l..pl..h..c..l..p..cs.......hV.h.l.ph.t.Gu.Cs.GCsu.ushT..L..KpGIEptLhpplP..p..lh.tV.........................	0	376	769	1014
+3505	PF01592	NifU_N		NifU-like N terminal domain	Bateman A, Wood V	anon	Pfam-B_772 (release 4.1)	Family	This domain is found in NifU in combination with Pfam:PF01106. This domain is found on isolated in several bacterial species such as Swiss:O53156. The nif genes are responsible for nitrogen fixation.  However this domain is found in bacteria that do not fix nitrogen, so it may have a broader significance in the cell than nitrogen fixation. These proteins appear to be scaffold proteins for iron-sulfur clusters [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.44	0.71	-4.19	16	4872	2012-10-01 20:52:23	2003-04-07 12:59:11	11	21	4284	25	1274	2971	2268	125.30	35	78.48	CHANGED	tYo-KVhDHahNPRNsGsl-csss.......hsGpVGu.uCGDsh+LplKVctpsshItDA+FpTFGCGSAIASS.ShhTEhlpG+sl--A.hploNp-IActLut......LPs.KhHCSshup-AlcAAltsYcu+phps	......................................................YpphlhDHacN.P......+N..h..G.ph.-ssst........................suh..h.s..s..P..sCG..D.s.hcLpl.+....l.........s..c..............p.............s......h.....I.....pD......s..+Fc..s.hGCu.uhASo.ShhT-hV..c..GK.o....l-EA....t............l........p............p...s...p.l...h...pp.l.t........................ls....s...s..c....h.c...s...s.hLu-s..s.lh.sulsca.t+ht.s................................................................	0	441	833	1074
+3506	PF03206	NifW		Nitrogen fixation protein NifW	Bateman A, Mifsud W	anon	Pfam-B_2891 (release 6.5)	Family	Nitrogenase is a complex metalloenzyme composed of two proteins designated the Fe-protein and the MoFe-protein. Apart from these two proteins, a number of accessory proteins are essential for the maturation and assembly of nitrogenase. Even though experimental evidence suggests that these accessory proteins are required for nitrogenase activity, the exact roles played by many of these proteins in the functions of nitrogenase are unclear [1].\	 Using yeast two-hybrid screening it has been shown that NifW can interact with itself as well as NifZ [1].	20.60	20.60	20.80	20.70	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.43	0.72	-3.93	39	208	2009-09-11 15:38:48	2003-04-07 12:59:11	9	1	203	0	87	189	12	100.60	30	92.76	CHANGED	Mo.......hlcph.....ccLouAE-FFpahslsYDscVVsVsRLHIL++FspYlspt...sh..ssh.s-sthhsph+shLp+AYpDFlsS.oPhpc+lFKVap-tstp..........hVsLsslps	..................hhpcl.....ppLooAE-FhpaFslsYDscllsVsRLHILKRFspYLttt......c......th.spppthtthRphLppAYpc.FhpS.sshpp+lFKVhppt.............hVslstl..t...............	0	19	52	70
+3507	PF04319	NifZ		NifZ domain	Bateman A	anon	Pfam-B_6057 (release 7.3)	Domain	This short protein is found in the nif (nitrogen fixation) operon.  Its function is unknown but is probably involved in nitrogen fixation or regulating some component of this process. This 75 residue region is presumed to be a domain.  It is found in isolation in some members and in the amino terminal half of the longer NifZ proteins.	20.30	20.30	20.50	21.10	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.47	0.72	-4.60	41	240	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	176	0	121	231	7	74.10	42	68.32	CHANGED	t.PtFphGp+V+sp+slRNDGTaPG..pchG-lLVc+GshGYVhsIGoaLQphh.IYuVcFl-pGhlVGCRccELpss	....t..PtFphGp+V+up+sl+ND.....G..TaPG..pphG-lLl.++G-hGaVhslGoa..L..Qp.h..IYsVcF...h-....p......uh...l......V....Gh+ccEL.s.h...............	0	31	76	98
+3509	PF01077	NIR_SIR		Nitrite and sulphite reductase 4Fe-4S domain	Finn RD, Bateman A	anon	Pfam-B_1092 (release 3.0)	Family	Sulphite and nitrite reductases are vital in the biosynthetic assimilation of sulphur and nitrogen, respectfully.  They are also both important for the dissimilation of oxidised anions for energy transduction.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null --hand HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.87	0.71	-4.87	91	15116	2009-01-15 18:05:59	2003-04-07 12:59:11	17	120	3409	86	2437	13876	917	143.60	20	41.54	CHANGED	susslRsspsssssshsptthhDs.........................ptlstplp......................tphpththPtKFKlulsG.........ssssCststsp.Dlullustcsth.................................................................................GaslhlGGthutp.ttsthhh......sah.t-.....p.lhphlctllphap........cps+t+p...Rlt.hlcch..Gh-cFtppl..tp.hsp.h	..................................................................htthps.hss..G...s..h.Cchs.shDs..........................................pshsttlt...........................t..h......s..p.h..p..p..h..t..h..P..t......K...h.+..h.....sluu..........Cs.N.s.C.ssst.sp.Dlu..l....lG....h....t...c...p....s.............................................................................................................................shplh.luut.h.s.......................................p...........................h....hh...t....h...h......................................................................................................................................................................................................................................................................................	0	719	1561	2066
+3510	PF03460	NIR_SIR_ferr		Nitrite/Sulfite reductase ferredoxin-like half domain	Bateman A, Dlakic M	anon	Bateman A	Repeat	Sulfite and Nitrite reductases are key to both biosynthetic assimilation of sulfur and nitrogen and dissimilation of oxidised anions for energy transduction [1]. Two copies of this repeat are found in Nitrite and Sulfite reductases and form a single structural domain.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.90	0.72	-4.35	174	13756	2009-01-15 18:05:59	2003-04-07 12:59:11	12	109	3391	98	2671	12133	911	66.90	22	18.80	CHANGED	htpps.t.h..hlplpls.s.....Gpl.ssp....phptluclu.....c..cau.t..upl.+lTspQs.l.ltslptpplsslhptLtph	..........................th......t....atlplphs..u.........Gpl.osc..................tlptls-lA.................c....cas..t......Ghh.+h.Tspps.l.hh..sspppplttlhptLt..s.....................	0	772	1683	2259
+3511	PF02665	Nitrate_red_gam		Nitrate reductase gamma subunit	Bashton M, Bateman A	anon	COG2181	Family	This family is the gamma subunit of the nitrate reductase enzyme, the gamma subunit is a b-type cytochrome that receives electrons from the quinone pool [1].\	     It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit [1].  The nitrate reductase enzyme, EC:1.7.99.4 catalyses the conversion of nitrite to nitrate via the reduction of an acceptor.  The nitrate reductase enzyme is composed of three subunits [1].  Nitrate is the most widely used alternative electron acceptor after oxygen [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.44	0.70	-5.00	66	2225	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	1577	10	386	1081	183	214.50	41	82.12	CHANGED	ls.phLaslaPYlslslhllGohhRacp-QaoWpocSSQlLcp+.tL+hGSsLFHhGILslhhGHlhGLLhPpshhcslGlopthhph.hAhhsGuhsGlhsllGhslLlhRRlsssRlRtsoohsDhhlLllLhlplhlGLhohhhuttph.......-hshhhplusWhpulhshpPs..uphlsslshhaKlHlhhGhslFslaPFTRLVHlaS..sPltYLtRs.Y.lhRpRp	...............................................................................................N.FhasIaP..YlshslFllGshhR............Y...cYsQaoWput...S....S.....QhL..-.++.thh.lu.S..sL.F..HlG.......I.L....s..l...FhG.H..h..h......G.hL...sP.....c...h...h...h...p....s.h........l....s............p.....s...h.....p....h.......h.A..h....hhG..u......h..s......G..l..ls.L....lG....h.s.hLlhRR.l.h..s..t..R....V...............R.s....s..o....o....ssD..ll..lhhlL..llps..hLGLhohshospph............Dhs...h....hp.lss...W.......h.p.S..lh...o...F.p.s....s......uph.h.s.sV.s.h.l.F.+l....HllLGhT.lFhlaPFTRLVH...l...aS...sPl..p..YlsRp..Y.lhRpR..............................	1	127	252	327
+3512	PF02087	Nitrophorin		Nitrophorin	Mian N, Bateman A	anon	IPR002351	Domain	\N	20.90	20.90	21.10	21.00	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.31	0.71	-4.49	3	15	2012-10-03 08:47:39	2003-04-07 12:59:11	10	1	3	66	0	101	0	166.40	42	85.60	CHANGED	CSTNISPKpGLDKAKYFSG.sWYVTHYLDKDPQ.VTDpYCSSFTP+ESuGTVKEALYHYNuKKKTSFYNIGEGKLESuGlQYTAKYKTVDKK+sVlc-ADsKNSYTLTVLEADDSSALVHICLREGsKDLGDLYTVLoHQKDuEPSAKVKuAVTQAGLKLSDFVuTKDLuCpYDD.QFTSL	.........................CopNlpsKpshDKsKYFoG.sWYVTH.Y.L..D.p-P..p..V.T.D.cYCuuF.s.s.+.p...u...sG.p...V..K...E.ALY.HY.Nsc.scs...o.F.Ys...l...u..E..u..p..l....pS....sG.....KY.T..A..K..ap...pVDKct..c.clc.cs.s...t..s.pYT..h..T..lh-sD.D..S.p.AlV..HhC...h....p...cus...c...s....l..hsLY..s....VLsRs..c..s..sp..s.s.s.KVKsAl.s.psuLKLscFhssKs....sCpYDs.phh.............................................................................	0	0	0	0
+3513	PF00881	Nitroreductase		Nitroreductase family	Bateman A	anon	Pfam-B_481 (release 3.0)	Domain	The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.94	0.71	-4.42	141	16517	2012-10-02 14:48:17	2003-04-07 12:59:11	19	110	4534	206	3919	12487	3614	164.20	18	68.07	CHANGED	lppR+Sh..R.pFpsps......lsp-p...lppllpsA.................ph......uPoutsh....psh....chhll.p.......stchp.......pcltphhht.h..................................................................thtpthhtsAshhlhh..........................................ssptttthshh...ssuhsspshhL..sApshGlusshhusht.......ttt............lpchl.sls............tplh..hhlsl..Gh	...............................................................................................................................................................................pR+Sh..+..p....a.p.sp.......lsp-.p...l.p.p.l.l.p.su............................................ph............uP.S.u.t.sh............Qsa.............+hlll...p..............stct+...................................pclt.ph..h......t...............................................................................................................................................................................................thttthh.t.p.A....s..h....hl..hl..........................................................................h....h.s.t...p....p.......h.......h.s.h.h.......ss.uhsst..s..h....hl..uA.p.s.h..G..lus...shhsuhp...................................tpt..........lpc...hl....s....ls.......pp........hp.h...hhlsl..Gh...........................................................................	0	1261	2568	3341
+3514	PF05211	NLBH		Neuraminyllactose-binding hemagglutinin precursor (NLBH)	Moxon SJ	anon	Pfam-B_6567 (release 7.7)	Family	This family is comprised of several flagellar sheath adhesin proteins also called neuraminyllactose-binding hemagglutinin precursor (NLBH) or N-acetylneuraminyllactose-binding fibrillar hemagglutinin receptor-binding subunits. NLBH is found exclusively in Helicobacter which are gut colonising bacteria and bind to sialic acid rich macromolecules present on the gastric epithelium [1].	24.40	24.40	24.50	24.60	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.56	0.70	-5.14	3	170	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	54	3	13	172	0	241.00	39	94.79	CHANGED	KKshLAluLuSLLlGCAhasulEsthPsctppppsspohE....osEhsh.LcFNYPl+ucQsPpNcHlVlLLcP+IQlSDNIsKsYpcKFccuLhLQlpoILE++GYpVlpF..pDcc-lshspKKKuaLVLcMcGpVuILEDlKhslc-ss........uLsc-clVDhSSGaVplNFlEPcSs-llHSFulDVSclcAlpcplcoT+ouSGGF.lsKThVHc.K-T.N+-DAI+KILN+hYAsVMp+hsKELTK+NlE+YcKsucEMKs+K	..................................................................................pKs.luhsluulLlusu.p...hht................................t.sh.hphsY.hpucp..s.tss+h..llLLcP.plQhSD.N.IsKsYpsKFcsuLhlQlppILc++GYp..V..lph...pDcs-lshsp..K+cuaLsLchsGplsl.LpDhKhs..l.pcss..........uhsctcsV.hSuGalplsFlEPpSs-slcSFslDlSclchhpc.....hlchp+o.suuGh....ls......s.......oh.....V.........Kts....NpsDAI+plLN+hYsplMpcls+cLTpKNl-pYcKssc-hKsp+.............	0	3	7	13
+3515	PF04170	NlpE		NlpE N-terminal domain	Mifsud W, Bateman A	anon	COG3015	Domain	This family represents a bacterial outer membrane lipoprotein that is necessary for signalling by the Cpx pathway [1]. This pathway responds to cell envelope disturbances and increases the expression of periplasmic protein folding and degradation factors. While the molecular function of the NlpE protein is unknown, it may be involved in detecting bacterial adhesion to abiotic surfaces. In Escherichia coli and Salmonella typhi, NlpE is also known to confer copper tolerance in copper-sensitive strains of Escherichia coli, and may be involved in copper efflux and delivery of copper to copper-dependent enzymes [2].	21.40	21.40	21.40	21.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.10	0.72	-3.59	17	993	2012-10-03 08:47:39	2003-04-07 12:59:11	7	4	912	6	119	541	17	87.20	46	43.00	CHANGED	YpGlLPCADCsGI-TsLhLppDGTahLpppY.s+csts.phsuphsWscsuspls.L.sstu-..tspahss-ptL.MLDppGphlpGpL	.acGlLPC.......A.......D....CcGI-...ToLhL.......c.......c.....D......G.......T..alhsEcY.LG......s.....+.-............c..P...s..o.F.suh.GT....W........s...c........s........u.......c.p......l.l..Ls.c..u...p..G.-....cs.....YY.+..s......p..s.s..s.LpML..Dp.-.Gpslpup.....................................................	0	27	68	98
+3516	PF04973	NMN_transporter		Nicotinamide mononucleotide transporter	Bateman A	anon	COG3201	Family	Members of this family are integral membrane proteins that are involved in transport of nicotinamide mononucleotide [1,2].	23.00	23.00	23.00	23.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.33	0.71	-4.82	105	2756	2009-09-11 15:40:44	2003-04-07 12:59:11	7	3	2145	0	399	1643	528	184.10	26	82.74	CHANGED	shlEhlAslhGlhslhLsh+pslhsa.hGllushlYshlhapspLau-hhLplaYhh.hs...lYGWahWp.ptp...ptp......pth.lpphshpphhhhlhhhhlsshhh.uhlhp...pas.........push......Pal..Duhsoshullupahhu++hlEsWlhWlllDllulsLaht+Gl...............hhouhlaslahlhulhGah..pWp+th	.......................................hlphluslhGllslh.hsuct.+h.hsahhG....llsss....l.ahhlh........a........p........h.........p.........L.Yuphlhplaahh.hs.....laGaa..tWp..ptp......................tpp................tplph..+h.h...s.hpp.h.......hh...h...ls..l.s...ll.shhlh...shhhs...h.s............................ssh....................Pah....Duhhh.slSllA.hLh.s++.a.h...EpWlhWllhsllu.lslah.hpuh...............hshsh.Yhlahh.ulhGhh...Whp.t..................	0	104	221	319
+3517	PF01233	NMT		Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	25.00	25.00	25.60	25.90	22.60	24.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.00	0.71	-4.62	6	493	2012-10-02 22:59:21	2003-04-07 12:59:11	14	9	326	58	293	473	38	152.50	55	33.97	CHANGED	-GPIDK.hs.-cVppEPhsLsuGFEWsolDlsDctQLcElYsLLs-NYVEDcDAMFRFsYStEFLpWAL+sPGW+.-WHlGVRVppopKLVAFIuAlPssl+Vp..sKslssVEINFLCVHKKLRSKRLAPVLIKEITRRVNlssIaQAlYTAGllLPsPVoTC	.........................................shc..plcpEPasL.Pp.uFpWsolDls..s..pp.LcElYsLLs-NYVED..DDsMFRFsYS.-FLpW...........ALp..PPGWh.pWHsGVRl...........p.....p.....o.pK.LVuFISAIPssl+lh.....................cp......h......h.............+.hsEINFLCVHKK.LRSKRlAP.VLI+.....EITRRV...NLpuIaQAlYTAGlVLPpPVuTC...................	0	93	151	228
+3518	PF02799	NMT_C		Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	20.60	20.60	23.80	20.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.23	0.71	-4.92	39	510	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	331	51	298	486	34	186.00	47	42.34	CHANGED	EVGFStLsss.T.....hs+tl+hYpLPcpspTpG.LR.McpcDlspVpcLLpcYLp+F.cLs.hF.ocEElpHWhLs........pcsVlhoYVVEsss..t+ITDFhSFYsLPSTVlpss.pHcsLpAAY.FY.soss.................ppLppLhpDALIlAKp.hsFDVFNALslhDNphFLccLKFG.GDGpLpYYLaNa+sss.hss.............oplGlVL	...............................................-VtFSpLstshT.....hpR.ph+hY+LP..c.................s...s.............p..TsG..LR.Mc.+DlstVpcLLppYL.p.p.F.cLsPsh.scEElpH...WhlP.......................p-pll.oaVVE..............ss..............s....tclTDFhSFYoLPSolhpps...pHpsL+AAY.aY.sssp.............................................................................ssLhpLhsDAL.IlAKp.psFDVFNALslM-Np..pF.LccLKFG.hGDG.p.LpYYLYNa+sss.hts............................pplGlVh.......................................	0	95	157	236
+3519	PF02070	NMU		Neuromedin U	Mian N, Bateman A	anon	IPR001942	Family	\N	18.40	18.40	18.90	22.80	18.10	16.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.68	0.72	-6.91	0.72	-4.42	8	56	2009-09-11 14:39:29	2003-04-07 12:59:11	10	1	29	0	18	49	0	23.70	66	18.09	CHANGED	aKlDEEaQGPhuuQSRGYFLFRPRN	.....hcEEhQuPhssQSRGYFLFRPRN	1	1	2	5
+3520	PF03980	Nnf1		Nnf1 	Finn RD, Wood V, Mistry J	anon	Wood V 	Family	NNF1 is an essential yeast gene that is necessary for chromosome  segregation.  It is associated with the spindle poles [1] and forms  part of a kinetochore subcomplex called MIND [2].	22.40	22.40	22.50	22.70	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.15	0.72	-4.06	26	221	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	191	0	149	223	3	104.50	26	47.01	CHANGED	spsLcssppQhsphhpppspcEFspIhcERslpp+LsELDcllpcAccRpct.t.............................sshhcsLsPpcllcupLhsthppphspLspplpplpt-NppLtpp..lpphccp	.....................t.hpplhcphhppLppshpcEhpcIhcEpslpttLNcLDcllpEA+p.Rcp..t.....................................................................ss.hpsh.sPcphlpuplh....shh....hpttspLptplpphptpNtpLtpplttt+p...................................	0	35	71	115
+3521	PF02898	NO_synthase		Nitric oxide synthase, oxygenase domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.00	21.00	21.90	21.70	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.17	0.70	-5.79	8	836	2009-01-15 18:05:59	2003-04-07 12:59:11	10	23	543	489	206	694	26	326.40	50	49.70	CHANGED	sssRssE-LLspA+DFlsQYYoSI+RtpScAHhuRLpEVpKEl-sTGTYcLTpoELlFGAKpAWRNAPRCIGRIQWuKLQVFDARcsoTApsMFEtlCNHIKYATN+GNlRSAITIFPQRTDGKHDFRlWNsQLIpYAGYKpsDGollGDPAsVEFTElCIcLGWKP+pGpFDVLPLVLpAsGcDPEaF-.lPPELVLEVPlcHPcYcWFpELGL+WYALPAVSNMLL-sGGLEFoAsPFNGWYMGTEIGsRNhCDspRYNlLEcVAp+MGLDT+sssSLWKD+ALVEINlAVLHSFQpsNVTIVDHHoAoESFMKHh-NEh+hRGGCPADWlWIVPPMSGSlTPVFHQEMlNYhLpPuFhYQ.s-sWKTHhWK	.........................................................Lh.pAptFIpphYpp.....h+h.....t.p.hppRlc....-lphEIcpTGTYph...Ttp.ELlaGAKhAWRNus...RCIGRl.WspLpVhDAR.......cssstpthhptl..spHIphATN.pGpl.+..ssIT.IF.s..+t..sG.t..s..h+I.aNsQLIRYAGYc.p.....G.hh.GDPAsh-hTcls..c.LGWp.s...p...t..s.pFDVLPLlhQh.s.s.c.s.Pcha-.lPscLlhEVPIcHP....c..a.....h.hpcLs....LKWYAlPhlSNMhL-IGGlpa...suuPFNGWYMsTEIGsRN.......hsDstRYN...lLE....cVActhsL.....DTp.+.s..sS...................L..........WK.......D+ALVElNhAVLHSFp............pp.sVoIVDHHoAucpF.pa.cNEtp.ttt.s..ss..ucWsWllPP...lS.solTslaH..p.t.h..s.N.hh..hpPsFhYp......c..p...........................	0	54	88	134
+3522	PF02474	NodA		Nodulation protein A (NodA)	Mian N, Bateman A	anon	Pfam-B_2183 (release 5.4)	Family	Rhizobia nodulation (nod) genes control the biosynthesis of Nod factors required for infection and nodulation of their legume hosts. Nodulation  protein A (NodA) is a N-acetyltransferase involved in production of Nod factors that stimulate mitosis in various plant protoplasts.	33.80	33.80	38.20	34.30	27.00	23.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.39	0.71	-5.02	30	1084	2012-10-02 22:59:21	2003-04-07 12:59:11	10	1	856	0	23	753	0	170.20	67	98.03	CHANGED	MRSpV+W+LCWENELpLuDHlELu-FFRKTYGPTGAFNAKPFEGuRSWAGARPElRsIuYDu+GVAAHhGlLRRFIKVGplDLLVAELGLYGVRPDLEGLGIoH..ShRVMYPVLQcLGVPFuFGTVRpALcpHlpRhs.RpGLATIloGlRVRSTLsDVahDLPP.TRl.EDlLVlVhPIGRshSEWPsGTlIDRNGPEL	.......................................-H.ELu-FFRKoYGPTGsFNAKPFEGuRSWAGARPElRAIuYDucG.lAAHhGlLRRFIK..VGp......sDLLVAELGLYuVRPDLEGLGIuH..S..l.R.sMYPlLp-LGVPFuFGTVRpALcpHlpRhs.R.pGlATllsGlRVRSThs-la.DLP.P.TRl.ED.l.LV.l.VhPlu.RshoEWPsGshI-RNGs..............	0	2	9	12
+3523	PF01798	Nop		Putative snoRNA binding domain	Bashton M, Bateman A	anon	Pfam-B_1362 (release 4.2)	Family	This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) Swiss:Q12499 from yeast is the protein component of a ribonucleoprotein protein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex [1]. Nop56p Swiss:O00567 and Nop5p interact with Nop1p and are required for ribosome biogenesis [2]. Prp31p Swiss:p49704 is required for pre-mRNA splicing in S. cerevisiae [3].	25.00	25.00	27.70	26.40	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.53	0.71	-4.91	16	1302	2009-01-15 18:05:59	2003-04-07 12:59:11	13	19	497	30	857	1287	98	145.10	41	29.75	CHANGED	plpchscplhpLt-hRppLhcYlcs+MsplAPNLosLlGphVGARLIuHAGSLppLAKhPASTlQlLGAEKALF+uL+.....o+ssoPKaGlIapushIppussps+GKluRhLAAKsulAuRlDshucp.ss....hG..h+pclEpRlcplcpt	..................................................................ltphscp.llpLschRp....pLhpYLps+MptlAPNLosLlGp..h.....lGARLIu.+A.GSLtsLAKhPAS.T..lQlLG......AE..K....A.L....F...R...ALK........T+.s...s...TPK....aG..l.IYHush..........ls..p.u..........s....s.cpKG+..huRhLAuKsulAuRlDs....h....u..-......sss........s..............hG.ph+p.plEpRLchhp..s..........................................	0	299	489	709
+3524	PF02451	Nodulin		Nodulin	Mian N, Bateman A	anon	Pfam-B_2163 (release 5.4)	Family	Nodulin is a plant protein of unknown function. It is induced during nodulation in legume roots after rhizobium infection.	25.00	25.00	168.50	32.00	19.20	19.20	hmmbuild  --amino -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.91	0.71	-4.85	6	33	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	2	0	5	25	0	114.60	33	83.64	CHANGED	sEAYESP+FKKFVTcCoSHVuETCSssss.pspEAl+..psshGLuaCLFDSMEp..CLs-HpAulhs.....................................psplcshsshPsolp.....................................................................................................s...........tP............................................lLIpTlpFRTVL+TCS+VSARoCLTAPNVATSsLsACLtPShNQCVYPsu....s.sssssPPI	..............h..ss+hp+hlT.souHVsppCS.......ptt.h...s...huhphhspM.t..Ch..atsth...............................................................................................................................................................h..hhphpsshthCo..oAp.ChssssVssSsL.th.hs.hppClY..................................	0	0	5	5
+3525	PF01189	Nol1_Nop2_Fmu	Nol1_Nop2_Sun;	NOL1/NOP2/sun family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.53	0.70	-5.03	10	8954	2012-10-10 17:06:42	2003-04-07 12:59:11	12	43	4410	23	2832	7258	1507	238.20	24	57.46	CHANGED	llpsssspsshslRsNspKtsRcshtpsL-ppulshpsluphsps..hshcpssulssLPtapsGashlQstSu.hsshhLsPpsc-t.............ILDhCAAPGGKToalsplhhp.pupllAsDhsppRlpplhsNlpRLGspshhlp...sDssc.tptssss......FDRlLLDAPCSusGsIc+cPcl+hhRp-pDItplspL..Q+cLLputh-hl.................KsGGhLVYuTCSltsEENpt..........sIchaLpc+scs-Lsspshscsht.ht.........hlphshphhP+ppstDGFFhAcLp	....................................................................................................................................................h..t..............t......t..............................h..............................................................................................................................................h......tt.....h...s......t...a....t.p......G......h...h...hl.Q.-tuo....h..s....s....h....h.....L....s.......s....p....s....s..pt.......................................................l.LD..h..C.......A......A......P.........GG.......K..............T............s........p.l.........s..........p...................h..............h............t...............t......p.................G..........t...........l..........h....A...........-h..s...t.p.R....l...p..h..l......t........p........s........h.....p........R......h......G.....h......p.......s...h......h.....ht............t-..u..t.......p....h............t..h..h...tt.......................................FD+...l...Ll..D.A..P.CS....G.........G....s........l.......R.......+..........c..........P............-..........h...............t.........h.......h..h...........p.............p......p.........h.......t.....p...l.sph...........Qtpl.Lptsh..phl.............................................+..s...G.G..h..llYuTCo....h..pEN..pt........................................................lp.h...h.....L....p.....p...t..........t.....h.....p.......................h...................................................................................................hp.h..P....t..........................-.uhhhs................................................................................................	1	951	1651	2323
+3526	PF04135	Nop10p		Nucleolar RNA-binding protein, Nop10p family	Kerrison ND, Finn RD	anon	COG2260	Family	Nop10p is a nucleolar protein that is specifically associated with  H/ACA snoRNAs.  It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA  snoRNAs (H/ACA snoRNPs).  Nop10p is probably necessary for the stability of these RNPs [1].	22.40	22.40	23.40	30.30	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.75	0.72	-4.23	44	426	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	393	22	298	416	50	51.40	49	80.10	CHANGED	hchhl.csstpc......lYTL+..pss.sGp.TtsuHPARFSP-DKYu+YRltlK+Rhs	..............hhahl.sssGpR......lYTLK........Kss.sGp......TpSAHPARFSPDDKYS+aRlslKKRa......	0	95	170	244
+3527	PF05048	NosD		Periplasmic copper-binding protein (NosD)	Moxon SJ, Bateman A	anon	Pfam-B_5499 (release 7.7)	Domain	NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ) [1]. This region forms a parallel beta helix domain.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.36	0.70	-5.21	120	1281	2012-10-02 14:50:22	2003-04-07 12:59:11	8	160	695	0	642	3494	729	202.70	19	40.37	CHANGED	hsNshsusshhh............sGlhl.ts............ssshl.....psssltpspsul...hhttupssplpsN....thpss.....thGlphhtuss...........shlpsNhhpssp...........tGlhlhsop....tt.slp.....sNplpsspt.......GI.hLptuss.......sp...lpsNpl...................ssspGlhlhsu..........ssNsls.sNplssN............shGlh...................hssS.......ps.....NplasNhF.sNs.slphssst...........sspW................ssst.................GNaW.uch.sG.........tD.tsuDG..IuD...s....sY....phs..ssh....DhlPLhtst	...............................................................................................................t.....................................................................................h..............t..h............t.sul............hh..t.s..p..p..sh.l..pss...........thpps..............phG.lp...h.h...sss..................shlps.N.h.h.ps.st................sG..lh....lhtss..............ps..plp..................sNthtssps..............Gl..h.l....p...t..s..s.s...............sh......lps.N.p.l...........................................t..ss.....s.....p.....G..l.h.lh.su..................spsplp....sN.p.hp.ss.......................t.h.Glt......................................hs.s.u..........ps..............Ntl.h.t...N.t...h...s.N.....t....h...........................................................................................................................................................................................t...................................................................................................	0	208	429	517
+3528	PF04054	Not1		CCR4-Not complex component, Not1	Wood V, Finn RD	anon	Pfam-B_13503 (release 7.3);	Family	The Ccr4-Not complex is a global regulator of transcription that  affects genes positively and negatively and is thought to regulate  transcription factor TFIID [1]. 	22.50	22.50	32.10	23.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.29	0.70	-5.60	30	447	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	288	0	299	459	11	319.90	38	17.68	CHANGED	sLLh-hs........ph.pshpspph....tphhpsFuphhptLpPhthPGFsFAWlpLISHRhFLP+lLp.hspppGWshaspLLhsLl+Fls.al+ssp.lscslpllYKGsLRllLlLhHDaPEFLsphHaphCssIPssClQLRNlILSAaP.+sh+LPDPFsssLK.l-hLs-hppuPplht..s.stsLps..tlKKslDsaL+t.tsssshlpplhst..lhhsppctt......sssphNl.......pLlNAlVLalGhpAlsphpppspssshssps..sthsllppLhpcLcsEsRYhhlsAIANQLRYPNsHTHaFspllLplFs.p.....sssppsIQEQITRVLLERlIVN+PHPWGLlITFhELlKNs.pYpFachsFl+ss.PEIcplFcsls+s	.................................................................................................ht..................t.t.......phh.sFspthphLpPhthPGFsauWLpLlSHRh..FhsphLt.............h......s.p...p.p............GW.shatpLLhsLhcals...saL+...ss...........p.....lspshphlYK..GsLRl.LLlLhHDFPEFLs-aHathCssIPssClQLRNlILS..Aa.P.cs..h..+L..PDP.....F..sssL.K.l..........-hLs..Eh.p...sP.plhs..shsssl.......thKp.lDpaLps.....tssssh...l.pp..lpptl.hs.pt.....................sssphNh.................LlNALVLYlGhpAl........tphpp.................pst....s.....s..............s.hs......s.....s...................sths.lhppLh...hpLcsEuRYhhlsAlANQLRYPNuHT+aFStslLhLFu................psppptIpEQIsRVLLERLIVpR..PHPWGLllTFhELl......+Ns.tapFaph.Fl+su.P.ElpplFpslhp.s.............................................	0	116	177	255
+3529	PF00066	Notch	notch; 	LNR domain	Sonnhammer ELL, Bateman A	anon	Swissprot_feature_table	Domain	The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR [1] and was shown to contain three disulphide bonds and coordinate a calcium ion.  Three repeats are also found in the PAPP-A peptidase [2].	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.82	0.72	-3.69	53	1456	2009-01-15 18:05:59	2003-04-07 12:59:11	12	302	120	25	783	1259	39	37.40	38	5.70	CHANGED	p.hppCs..........ttCtpph.usGhCDpp..CNshsCtaDGsDCs	.........................t....pCt..........ttC.tsph..uDGhCDpt..CNsttCtaDGsDCp.	0	251	317	518
+3530	PF03000	NPH3		NPH3 family	Bateman A	anon	Pfam-B_1584 (release 6.4)	Family	Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay [1].	20.60	20.60	21.40	20.80	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.58	0.70	-4.87	51	658	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	36	0	421	661	0	228.20	33	41.97	CHANGED	pD.WWhEDl.stLsl-hacR.llsuh+u+..slpsclIupuLhtYAp+hLssh.............................t.sss.sppcp+tllEoIlsLLPs.c+ss....l...ospFLhtLL+sAhhLsuut...ss+pcLE+RIGhQL-pAol-DLLIPu.........hssp..........slYDVDhVpRIlcpFlpp..................t.........................................t.tt....ts.stsshhpVuKLlDuYLAElA.sDs.NLplsKFhuLAE...slP-tAR.hcDGLYRAIDlYLKsHPtLo-sE+c+lC+lhDCpKLShEAC	...........................................................sWWh-Dl.s.Lplshap+.llhuhcsp...sh.......p.ph..lutslhhYAp+h.L.sh..................................................................t..ss....tptcp+hllEslls...lLPs..c+ss...................ssspFLhtL.L+sA.hhlpsu....ss.+tpL.E+RluhQL-pAolsDLLlPs............ssp................shaDl-hVp.Rll...ptFltt................................................................t...ts..sstsshhpV...u+LlDsYLuEl.A..D..s.sLphsKFhsLAp...slPc.AR....hcDGLYRAlDhYLK.....s....H..P..tlsctE+cclCp.lh-spKLS.-As......................................	0	54	267	350
+3531	PF03116	NQR2_RnfD_RnfE		NQR2, RnfD, RnfE family	Mifsud W	anon	Pfam-B_2882 (release 6.5)	Family	This family of bacterial proteins includes a sodium-translocating  NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium  pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting  (by an unknown mechanism) the transcription of the transcriptional activator ToxT [1]. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted [2].	22.90	22.90	23.30	23.60	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.05	0.70	-5.24	169	2456	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	1700	0	519	1837	989	327.80	35	93.22	CHANGED	shhspsuPHl+ssh.shp+lMhhVllAhlPuhhhu.hahaGhts..................................................................LhhhlluhlsulhhEslhtplRp+pl...h.DtoslVTulLlAlslPsshPhWhlslGssFAllluKplFGGlGpNhhNPAlsGRshLhh.uaPspM.os....Ws...................s.............s........Duh....osATPLshhpss.......................h........................p..hs.......hhshFhG.h.........GulG..EsSsLulLlGGlhLlhp+lhsW+Isluhlsuhhlhuhlhthh...s.............s.ht.hsshaHLlsGGhhhGAhFhATDPVouuhTs+G+hlaGhhlGllshlIRsau.uYPEGlhaAILlhNhhsPLIDa..astspshu++	......................................................................h.hhtsusas.+.sth.ssp+lMhhVllAhl.Puhhht..ha..a.G.hts......................................................Lh..hhl.uhlsulhhEslh.h.............pl.R.++.....pl..............h....-...tus.l.......lTulLlAlslPP.......hh..PhWhsslGssFu....llluKpl.a.....GGlGpN.hNPAh.sGhs..h.Lhh....u...aPspM...ou.......Wh....................................s................................hDGh....otATPLsthpsu................................................htt........hs........ptht.....hh.shahG...ls.......GuhG...Eh..ssL.AhLlGG.l.hLlap+.lhpW+...Issuh.l..lsh..hlhuhl.hthhu........................s.hh..hsshhH.LlsG.u.....hhlGAhFhATDPVouuh.Ts+G+hlaGhLlGlhshlIR...shu...uYP..-..G.....lhaAlLluNlhsPLIDaash.+shs+................................................	0	174	339	445
+3532	PF01566	Nramp		Natural resistance-associated macrophage protein	Bashton M, Bateman A	anon	Pfam-B_624 (release 4.0)	Family	The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains [5]. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis [1]. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria [1]. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis [1]. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals [1]. The yeast proteins Smf1 and Smf2 may also transport divalent cations [3].	29.80	29.80	29.80	29.80	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.11	0.70	-5.66	126	5115	2012-10-03 01:44:59	2003-04-07 12:59:11	13	22	3156	0	1386	3862	534	343.50	27	78.31	CHANGED	hATslpAGupaGYpLLWlllhuslhshllQthuA+LGlVTGc....sLuphh+cca......s.phhshhhhhhstlushAsslAEllGs.AluLplLh..s.......lPh.........hhusllsuhsshhlLh...ptu.a+hlEtllhsLlsllslsFlhplhlspPsh......splhtGhl.Pshss..........sslhls.....lullGuTVhPaslaLHSullp.s+t..h..............................pt............l+hsph.Dsh.lul.sluhllshulllhAAusha.....tstt..tl........................sslpsAtpsLpP........lhG..hA...shlFuluLluuGluSshsushAGthlhpGhl.phchsh.h+h.hsp.hthhsshhslhhhussht............hLlhSQ...VlhulhLPhsllsLlhhsss+p.....lM.G.pasNsh	............................................hoshtuGu.paGY.t.............L.La.l.ll.lu.slhuhllQ..............hhuu+.L...Gls.T.G.t............sLuch.h.p..c....ph.............................s.p.h.h.....sh.....hh.h.....l.....hstl.u..h.....h...........Ao..s.l......u..E..................l.l.Gu....A....l...u..l....p.l..Lh...u.............l.sl......................hh.Gs....ll.Ts.ls.sh...l.l...L.hh..................p..........t..........G......h+hl.Etl...lh.sLl.h.h.....lh.....l..s..a..h..h..t..l..h...h....u.....p.....P..s...h.........s.pl.h.....p..Gh.l...Pp.h.h.............................tslhhs.........................lul.l..G.....AT.l.MP....H...s..l...a.LaSulsp.s+t.hst.....................................................................cp........ptlphsp....h..D.ss.lul....hl.u....h.h.l.N..h....slll....huAushh.......ssts....sl...........................................................................................ssh.tp..sh..ps..L....ps...............................hh....G.....hu......shlF...u.lu....LlAuGhsSol.su.........o..h......uG..p...hl......hp......G.hl......p....h......c.h...s.....h......h..............h............R....p.........h.l............T..........h....hl.....P..s....h..........l.l..h.h.h.hs.ssst................................lL.l.h.u.Q......Vlh.u...h...t.L..Ph.sl.ls...L.lhh..o.s.pcp..lMG.phhs..h............................................................................................................................	0	404	819	1134
+3533	PF03813	Nrap		Nrap protein	Bateman A, Wood V	anon	Wood V	Family	Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus [1]. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript [1].	22.90	22.90	22.90	23.50	21.70	22.60	hmmbuild  -o /dev/null HMM SEED	972	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.00	0.70	-13.73	0.70	-7.02	26	425	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	280	0	303	441	12	679.90	22	81.89	CHANGED	SauL+Tulp.p.psh..slDlslTMPcplFpcKDYLNaRaaaKRAaYLAhlAttL.....ccsts.thplpasahssDsLpPlLhlp...Ppsppssc...hco+....hpIpllsuhPpslFs.p+LLPs+NsIRsspssp.............PTPaYNuollo-sshstYhKhLapst+....ps-uF+DAClLGRlWLpQRGFuSuhpp....GGFGsFEauhLhuhLLpG....G......G.pGpplLhpuaSSYQLFKuslpaLAspDL.tppslhhsuss..............httshpsPslaDssptlNlLhKMoshSYphL+pcAphTLphLN-stpDpFstlFltKhs..shh+aDtllcl...............sphssspplphhphps.......h..plaplLc+AL.....G-RlphIplp..tpsppsaslpp+hsspttp.......slplGLllNP.ccsp+lVD+GPuu....EcccEutpFRpFWG-KA-LRRFKDGSIpEolVW...Ss...ssptsIlppIlpYlLcpHlphs..scclph....hucpFcphL..s..............shsssstsuFtsltcAFssLpKslpsl-.tLPLsl+pltPsussLRYoulp.PhPh................tsssh..-VllQFEoSu+WPD-LsAlp+TKsAFLLKIu-pLp.sss..hpshlsh-pp...hshthstshLsllpspGasFRLRlhp-REpsLhcRtlt........ssssptK.tpst.shhtac+pahtsP+HTpslpsLsp+ashaSPTlRLhK+WhsuHLL..ssHl.s-EllELlsl+sFlpPhPassPuSspsGFLRsLpFLucWDWpp-PLllDls.............................scLstpphctIpppFpshRp..DPsh..sp...sshFVAoc.D..ssGlhWo.....ptsshslAsRlTuLAKuAh.pllc....ppGh.............phslspLFpsuLpsYDFlIpL+sp.slpspps................ssspFKNL..pp..stsp....hsp.....tsshc.h.taVc-LptpYu....ssllFFps.........spsssVIuGLWs.Pphhps+sa+lshshsspPhs......................s.cpVpl..N+-AllsEIupLGs-LlpsI-s....p	.....................................................................................h-h.l.hPtthht.cDhhs.ph..KRshalthlht.l............................................th....tht.....ttp.h.s.l.l....................t..............................................lplh.s.........t....h...t..........+h..s.t.......t...ssl........+.................................t.............................................sTPhYNt.lh.p......h......phh.th............t...thtpuhhLh+hWhpp+t.......h..t................................tshs..th...h..sh.....hh.hLhpt...................................l...hs....shphh+.hh......hlu..t..p.h.....t.h.ht...............................................shh.c..t.hNlh.phs...ht............l.p..t..A.t..sh.h.h.pt............s..t.....F....t.hhh......................taD.hhpl...................................................................................l.thltpuL.......spRhphl.h........................................h.h..ttt................................l.lul.h.ps.tth.ph..lphGP.s......................pt......tuttF+pFWG.t.+.upLRRFpDGsIhcs.................hlW....................p......tt..l.t......plhp.ahL..thH..h........tptl...............t.hp..h.........................................s.t.....hhpsapplt.................p.l.t...........hp.......lPLplttl.shts.hRhsp...s.s........................................................................................phh..hph-tSspWPpph.ulphh+hAh.l.pltc.Lt.t......................................................p...t.....hplh.h....p......uhhF+h.lhhth-....hh.t...............................................hp..h...s.htthlpsht.....t.pa...hussh+lhKpWhtsp.hh........hh..tp.h-Llsh.ha...........h.............p............................s..................Pt....................o..suFh+hL.hlupasWp..pPl..ll..shs.............................t.php...tp..tltpth.t.Rt...........................hhlso..D...................ts.....hao.................t..s...lhtphh.lA.ttu.h.thlt........t.................................ph...t.....lF...h...ssht.a.Dh..ll.lp.t.....t..............................................................................h................................................hp.......hht...Lp.....at........t.hhh..t...........ttt.lshhh..............h.t..................................................................................t..........................................................................................................................................................................	0	118	180	266
+3534	PF03916	NrfD		Polysulphide reductase, NrfD	Finn RD	anon	DOMO:DM04466;	Family	NrfD is an integral transmembrane protein with loops in both the  periplasm and the cytoplasm.  NrfD is thought to participate in  the transfer of electrons, from the quinone pool into the terminal  components of the Nrf pathway [1]. 	20.30	20.30	20.30	20.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.25	0.70	-5.02	13	2377	2012-10-01 19:35:38	2003-04-07 12:59:11	9	13	1174	0	635	1611	579	296.60	25	81.36	CHANGED	ssstphssl...sWuhslAh.YhFll..GluAG..ulhlAhhh....chhptp..ttt..s.s...tl.lpsusll.uslsll.h.ullhllhDLs.RP..+Fhthh.h...asF..o...Shhs..h.Gl..hhht..sahslll...laLhhhhct..pltsht......h.s...........ht.hlt+....lhsl...u...........tthsp..sltllh.hlhAlhluuhTGaLlSslhuhPhhpsslLPs.hFlAuuhuSG...lAs.hllshll.hs+hps.csp.ssthlpphthhl.hht..phhlLs......h....hhV.G..hth.......ssstp..hpuhps...A..........Lpu.hh...s......hhFhlGlshlGlhlPllLt.h..hlsc.lptshshl.lhuulhsLsGshhhRahllhsG.hh.lu	..........................................s....h.tsh..sWs.h..IAh.alalh..Gl.u..uG..uh.h.l.Ahhl..................hh...apht.......tht....s.t.......hl..h+.s.s.hl......h...u.h.h.u.lh..l..Ghlhl...hhc....l............s....R..........Pa....ph....h.......h...h.....h....h.........h..h.......s.......a........s..................Sshs...h..ss....hhhs........lY.h..s...l.hs.....la.hhh..hh..t....cl.h.tht............................................................lp+........h....hth.....................................................thhh....hlts.ls....hlL.u.s....hl..tuh..sG..hL....l..o..u.h..h.s..h.....P......h......W..p.....s........s..h.....hPs..LF.l..hou..h.uG...h.uh...slh......h.h....h..........l.....t.........t...........p.hp...........s.....p..........s.....-....t............p...h......l...t..th......hsh....lhs....tl.hl.lh.....................s.......h...a...l...s......lth.............uss.t..h......hp.th.sh.....s...............................................h.s.u..s..h..a.........s.................hhF..W.l.t.l.l..h.h.s..h.l..hP..l...l...l......h...........hh.....s+...h.....p.p.s..h.t....h....l......h...hsu.h....h...sLlGs.h...h.h.R.h.llh.s..............................................................................................................	1	251	451	567
+3535	PF02723	NS3_envE		Non-structural protein NS3/Small envelope protein E	Mian N, Moxon SJ, Bateman A	anon	Pfam-B_1913 (release 5.5) & Pfam-B_7381 (release 8.0)	Family	This is a family of small non-structural proteins, well conserved among Coronavirus strains. This protein is also found in murine hepatitis virus as small envelope protein E (e.g. Swiss:O72008).	25.00	25.00	27.80	27.60	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.91	0.72	-4.06	12	303	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	234	0	0	157	0	78.20	35	97.76	CHANGED	M.h..slhhh-ssshVlshllhhllhllhLllslAhLshI+LChpCsshsNshlhtPshalYs....hYpsa..clpP.ss..s.l	......Mh..shsht-TsshVlshlhlhLlhllllllslAlLssl+LChhCCslsNshllpPolYlYs+s+phYpsa..phps.................	0	0	0	0
+3536	PF02071	NSF		Aromatic-di-Alanine (AdAR) repeat 	Casavant T, Bruckert F, Bateman A, Mian N	anon	IPR000744	Repeat	This repeat is found in NSF attachment proteins. Its structure is similar to that found in TPR repeats Pfam:PF00515.	27.00	1.00	27.10	3.10	26.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.98	0.77	-6.20	0.77	-2.28	51	10	2012-10-11 20:00:59	2003-04-07 12:59:11	15	2	2	0	5	284	6	13.00	28	22.38	CHANGED	AuptappAupha	.....AuppYpcAAcha......	0	5	5	5
+3537	PF05064	Nsp1_C		Nsp1-like C-terminal region	Wood V	anon	Pfam-B_3555 (release 7.7)	Family	This family probably forms a coiled-coil [2].  This important region of Nsp1 is involved in binding Nup82 [2].	22.50	22.50	22.50	22.50	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.49	0.71	-4.45	30	353	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	282	2	233	349	0	113.90	30	21.20	CHANGED	ssspssp.sssss........LcsKsL--lIsKWop-LscppKpFppQAspVspWD+hLl-NG-cIspLassshcsEpsQscl-QpLpalcsQQcELEphLssYEpchcplh.sph..sps.......stc	........................hs.....t...ssss.s.........hphppL..--lIs+Wsh-Lpcpp+cFhpQAspVssWD+hLlcNGc+IppLap.cstcsctsQpcl-ppLshltsQQcEL-shLsshEcplcp...sp........................................	0	80	128	189
+3538	PF03146	NtA		Agrin NtA domain	Bateman A	anon	[1]	Domain	Agrin is a multidomain heparan sulphate proteoglycan, that is a key organiser for the induction of postsynaptic specialisations at the neuromuscular junction. Binding of agrin to basement membranes requires the amino terminal (NtA) domain [2]. This region mediates high affinity interaction with the coiled-coil domain of laminins. The binding of agrin to laminins via the NtA domain is subject to tissue-specific regulation. The NtA domain-containing form of agrin is expressed in non-neuronal cells or in neurons that project to non-neuronal cell such as motor neurons. The structure of this domain is an OB-fold [1].	20.80	20.80	20.80	22.80	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.79	0.71	-4.49	2	48	2009-01-15 18:05:59	2003-04-07 12:59:11	10	18	29	4	20	43	0	116.40	73	11.37	CHANGED	TCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDlVApESLLDGGNKVVIuGFGDPLICDNQVSTGDTRIFFVNPAPPYhWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKP	.....CP.E+sLE..+REEEANVVLTGTVEEIlNlDPVp..pTYSCKVRVWRYLKGK-l......Vsp....E.sL.LD...GGNK...VVIGGFGDPLICDNQVSTGDTRIFF.VNPAP.YhWPAHKNELMLNSSLMRITLRNLEEVEaCVE-K................................	0	7	8	13
+3539	PF02136	NTF2		Nuclear transport factor 2 (NTF2) domain	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR002075	Domain	This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.45	0.71	-3.72	43	1695	2012-10-03 02:27:23	2003-04-07 12:59:11	15	45	499	189	981	2094	108	119.60	22	36.72	CHANGED	luptFlppYYpthss.....c.ptlsphah..t-sShhshsGp................thpGhpsIscphtsLshsp......h.ptplsslDsQ.......ss.ttslllhVsGplpsssp..h...ppFsQsFhLsspp....tsaaVhsDhaRh	................................uptFlp.pY.Yphhsp...........sh....p.t.LtphY.........tcs..o.h..h..sh.tsp......................................................shp.G..tp.sIt....c.t.h...p...s.L..s..hsp.............h..phpl.p.s..lDsp...............................sshpssl.ll.V.sGtl..............p....s..sp..................hpFsQ..sFlLssps..........ssahlhsDhhp...................................................................................	0	254	446	711
+3540	PF00483	NTP_transferase	ADP_glu_Plase;	Nucleotidyl transferase	Finn RD, Bateman A	anon	Bateman A	Family	This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.68	0.70	-5.08	64	22811	2012-10-03 05:28:31	2003-04-07 12:59:11	18	112	5108	164	5670	20398	12452	242.50	22	69.14	CHANGED	tulILuGGsGTRLaPLT+shsKphlshhsp...shlphslsslh...uulpc.lllsspppphhlpctltcssphu.........lplphshpstsc.........GoAsAltlut.hltppps......hLlLuuDtlhp...satphlppttspss....ssohhhhsspssotaGllchs......sst......plhpFhEKPptsp.....................sshsshGlYhassslh.hh.p..lpp.tctcspls-hhtthlcpsphshshhhps...................................WpDlGohcula-usttltpt	.........................................................................................ulIh.Au.G...h..G..T.R..h......h.......P....h...T........c....s..........h.......s..........K......t...h.l......s......l........s...........s.......+....................s...........hIp............a.sl....p...p...h.......h.......t............u..............G.....l.....c....c.........l.....l.l....s.....s...t.........t....p.........t.........p...t.....l..p...c....h...h....s...p..s.......p..ht......................................h..p.l.t.h..h...h...p..s...p.st.........................G..h.u...p..A....l...h...h..u...t..t..h..l.ssps...................hllL.s....s....D....h...l..h.s.......................sh.p...p....h...l........p.......t.........t..........t....p...p...s.....t.....................h.....s..s.............h..h..h......h........h....p...p....s...p....t...a...G....l..l...phs......................................pps..........pl...h...p...h...h...E....K.....P..p....t..s.p........................................ssh..s..s....s..G..hY....h..h.s..s..p..l.....h...........h..h...........p............................p.................t.........t.....t.......s......c........................h....p.......-......h.....h........h...h......h...p....p.....t...p....h........h...t....h...hts........................................................................................................h.D.hG.s....htshhph.......th...........................................................................................................................................................................	2	1857	3653	4776
+3541	PF05014	Nuc_deoxyrib_tr		Nucleoside 2-deoxyribosyltransferase	Bateman A	anon	COG3613	Domain	Nucleoside 2-deoxyribosyltransferase EC:2.4.2.6 catalyses the cleavage of the glycosidic bonds of 2`-deoxyribonucleosides [1].	27.80	27.80	27.80	27.80	27.70	27.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.36	0.71	-4.20	107	1106	2012-10-02 19:28:18	2003-04-07 12:59:11	10	7	886	35	291	866	351	125.70	22	73.25	CHANGED	lYLAuPh.Fs..t..sphphspchpphLpphuh....psh.hPh.............ptph......s......s.thuptlaptslptlcpuDsllAs.ls.shc......sDsGTuaElGaAhAhsK......Plhshps-hc.........................................p...thshNLM	.....................................lYhAush..Fs....t...tp....hphh.p.p.lhphlcptsh..........phh..hPh..................ct.ph........tt.........tshttsptlhpsDh.pt.lppuD.lllAh.ls..s..........DsGouhElGhA.hA.h.....s.K......Pl.l.s.hhpstp......................................................................................................................	0	83	165	228
+3542	PF03825	Nuc_H_symport		Nucleoside H+ symporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.27	0.70	-5.71	4	1944	2012-10-03 03:33:39	2003-04-07 12:59:11	11	11	949	0	284	2015	437	383.60	38	93.67	CHANGED	Mshsh+LplM.FLQahIWGuWhssLhsYMhhoh.FsuuplGhVYSuhGIAAllhPhlhG.lAD+ahSAc+shAlsHhlGAlsLahAApsTs.tshFhlhLl.ShsYMPTluLoNSIuausLt....DssssFPsIRlhGTlGaIhu.......hhlluhuslE.oph.LhIuAusShlLusaALTLP+hP.scppAspulsshLGLDAFhLh+s.phhlFFlhohlhus.Lphh.lFuNsFLpshst.......hhsphuollhSluQhuElhFhLslPFFLpRaGIKsVMllulVuaslRFuhFAYG.DssshshsLLlLuhllaGsuaDFF.lou.lFV-pcsssslRuSAQGLFhhhspGhGsllGuhluG.hhlchaohsG.....shDWpTlWLlhAuhulhlAslFhhhF+.scs	..........................................................................................................................MthphpLphh....Flp.ahl.W...Gu...W...h..s...s....L.u.....a...h.h.s......o..h..Fsuup.....IGh.l.Yus.h.uIAA..ll.h.P.h.L...l.G...h...l...u...D...+...a...h..s...Ap...+....l....h....u....l..h....p.....h...s...u.A......l....h..........h.......a.........h.......A................A.......p...........................T......s............s...s...h....F...h...l....h...L..h.........u...h...s...Y...M...P..T....l...u..L...s...N..o..lu.a..s..plt............D.h.s.p.D.FP......I.R..la....G.TI......G.F..I.h..u...........................h........h...h....l...........u...........h..........s....s...h...p.....o...........p...h........L....h..I..s...u...........u....s....S..h..l..L........u..l.......a........s..............h...s.....L.....P......c....h......P.........s........c..p.........p..........u.............p....p.....s....h..p.....s....h........L.G....L.......D..A....h..s......L...h.+...................s...+.p...h.....h.l.F....F.l..h.....u.....h.L..l.u..s...s...L..t.h..h......h...Fu..Ns..a...Lp.s.hu............................h..s.p.p.s...o..h...h..h.......o...l.uQ..h....S....El.h..F.hL...s..l....PF.F....h+....R.a....G..I....K..pV..h.L.l.u...h..lu..h.s.l.Ra.u..hF.u...aG.s..ss..........h......sh.s.L..Ll...L...uh....l.....laGs.u.FD.F.a...lou......laV.-pcs.s.sp.h.Ruu..AQGl.h...h...h...h...sp...GhGshlG.sh....luG....hh.h...c.h.a....s......s.t..........................................hh.s....W.ps.h.W.h.hhA..sh..hl.l.A.hhF..h..hh.F+.pc.h................................................................................................	2	107	174	238
+3543	PF02321	OEP		Outer membrane efflux protein	Bateman A	anon	Bateman A	Family	The OEP family (Outer membrane efflux protein) form trimeric channels that allow export of a variety of substrates in Gram negative bacteria.\	   Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.	30.90	30.90	30.90	30.90	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.95	0.71	-4.70	113	30969	2012-10-02 20:27:15	2003-04-07 12:59:11	13	38	2653	50	9040	27392	6704	187.10	16	75.76	CHANGED	hpphhptshpp....ssplptt...ptphpts.ptphphtpst.h.hPplshssshshptststtht.................................................hslsl......shslas.....spttsphctuptphptsptphppsppplthpltpsahphht.spppl.phtpptlptscpthphtpppaptGthsh....s.lhpsptp..hhpsctphhpsptphptshtpLtthhu	.........................................................................................................h.t.slpp....p..ss...lp..tA.....ptp..lptA...ptplp..hucu.......s...h..h......P...s...l....s...l.....s..u....s...h......s...h..s...p..s...s..h.s..s..h..h.t.t.t...t.................................................................................................................hu.l..s.l.......................................sh...s.l.h.ph..............Gphps...plc.t.A..ptphp..t..u..pt..p..h...p....p....s....thsl...h..t...pl.s.p...sa.hs.htt...tpppl..p....h.t...p........p.......t.l.p.s.t....p.ps.hc..h..s..p..p......p.a..p......s...G..h..ssh..h..........-..lhpAptp.....hhps.p..tp.h..hpsptphttsthpLtthhG................................................................	0	2657	5583	7554
+3544	PF02265	S1-P1_nuclease	Nuclease; 	S1/P1 Nuclease	Bateman A, Mian N	anon	Pfam-B_2480 (release 5.2)	Domain	This family contains both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity.	21.90	21.90	21.90	22.00	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.12	0.70	-4.75	81	645	2012-10-01 21:01:47	2003-04-07 12:59:11	11	7	360	1	375	699	285	243.10	24	82.02	CHANGED	WGppGHhhlupIApphL.sspstptlpplL.ss............ssLuplusWADcl+p......h.................chsus....WHalsh.s.t..........t...aspsh....t.s.ppss.lluuIpphsstLpctpts..ppp+........spALtaLlHFlGDlHQPLH.suh......ttDpGGNslpVpah......scp.....s........NLHplWDothl..psh.t.............shsphsssL.pphs....tpphpsht........h.s...s....................htWApEShphup..phsh.....ssspssps...Lus..p.YhtsthsllcppltpuGlRLAshLNplhs	............................................................................................................WuttGHhhlutlApph...L...sspstttlp.plLst...............................ssl.sp...husWs.D...pl+t.....t.....h.....................................................ph..sus...hHal.shst.................................................spsh..........tp....s..psts..lhsulp..phtp.tL.t...stpts........ttpp..........................................s.uLta...lsHhlGDlH.......QPLH.s.uh.......................tDtGGNplp.lph...........spp...........s.............................NLHplWDst...hh.....pphht...........................................shpthh..ptl..pphs..............tpphpth....................................s.s....................................tt.asp.-ohp.hsp..p..hsh............................th.tstp.............lst....p.Y..ht..p..ths..lsppplt.uGhRLAthLstlh.t...........................................................................................................	0	171	268	338
+3545	PF03066	Nucleoplasmin		Nucleoplasmin	Griffiths-Jones SR	anon	Pfam-B_2930 (release 6.4)	Family	Nucleoplasmins are also known as chromatin decondensation proteins.  They bind to core histones and transfer DNA to them in a reaction that requires ATP.  This is thought to play a  role in the assembly of regular nucleosomal arrays.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-4.69	23	444	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	114	62	203	360	1	149.80	36	64.51	CHANGED	pspsaLaGCELspccpphoFcs.....t--c....cspHpLsL+olCLGspAK-.EhNlVElpu...hsh-upp.lplslAsLKsSshPhVolsGhElsPPVTFRL+sGSGPValSGpH.lshtpt.t.t................................................---EE-p--E-D-ED----pppE-.sPsKps+	.........................................................................pshhaGCELpucc.shpFcs...........-p-.........cs-....HpL.sL+.p...lsLGssAKD...Eh..p.lV.Espu...hsh..-up...lcVslAoL..Kh..S.s.pP.t......VoLs..s..Fp.l.s.P.PVs....h..+L.+.........sG....S......GP..V..aloGp........H.h..ls..hp.p.-t..p....pc...........................................................................pc--...-tt....---p-..-..-..cp......t.................t...........................................................................	0	29	44	89
+3546	PF03177	Nucleoporin_C	Nucleoporin;	Non-repetitive/WGA-negative nucleoporin C-terminal	Mifsud W	anon	Pfam-B_1212 (release 6.5)	Domain	This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterised by the FG repeat Pfam:PF03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore [2].	25.90	25.90	26.70	25.90	25.50	25.60	hmmbuild  -o /dev/null HMM SEED	587	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.99	0.70	-6.00	63	645	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	273	7	432	629	4	485.40	17	42.05	CHANGED	hsssh.pppLchhhpslpsLhcFlppsts............................................................hstppchtlhtctctlsuhhtLhpphpcthshhp.hlhp.............................p............hsshhhhlsp.sphpplhshtacplht.....sp.p.tp.htp.Llsshlspslhpsu..th-.phusth...p.ps...........ssh.t.........................phhpup.pssh.shcp.hchhlp...............hpth.tph.......shpshpptssphhshphhttshtl.hhphsptt.spsppshphhpc.tt.pps....+p..ht.htp.hshac.shplhcphcshsshsp.h................................t...ppttphppch.phhtphs-.sFthtlYcahlpp...sth.phh.phppsalhpaLpc..................................thucLhWlahhppp.cahpAApsLhpL....sps..................hpcRl-hhhptluthsst.......s.................htphlpclpchl-lsplQcplhp.hlps.tph.....................ttp..h....pthhpt.....................Lhsphshshphh.................................lpLthhphss......stthlptlWpchltp..s...p....pttttt..........................hpthphthsslhpplpts.hshshsthh.h	................................................................................t......pplp.h.pthptLhpFlpp.t.h...........................................................................thttphth.tctptlt.....uhhtLh...ph.t...ph.th..ht..hh.p................................................................................t.............hp.h.hhhtp.pt.pplh...thhhc.p.....lh................p...hp.....hth.l...hs.l..hthhpsu.............hc.thsphh....p.tp..............................s.h.p.....................................hpup.ph....t.h.p.....hc.hhp.....................................ht.....h..................................htth......s.tph.hp..hp.h...t.hhh.h......hh........hst.t.....p....t.t.s.p.......pp...t.....tp........p..........pt.....h.p.httap.hhp...hh...p.ph....shs.ths..h......................................ttsp.hpph.ph...hpp.t-....Fp..hlapWh.l.....pp...........shh..ph.....h..p............p.pshltpaLpp...........................................h.cLh..Wha.hppp..pat.pAA.psLhpL.u...spp.....................................hpc+hthhhtt.lsthsstt.......................................tphlcclppphc.lhplQpplhp..hlpt.ttt...........................................................th.t...................httLhsphs.shp..h....................................................hph.h.p.tt.t...........p.thhpthWpphlpp...p..........ptt.................................h...thh.lhphh..........................................................................................	0	144	236	357
+3548	PF01773	Nucleos_tra2_N	Nucleoside_tra2; 	Na+ dependent nucleoside transporter N-terminus	Bashton M, Bateman A, Yeats C	anon	Yeats C	Family	This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the N terminus of this family	21.50	21.50	22.10	22.10	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.15	0.72	-3.64	166	4054	2009-09-11 09:51:31	2003-04-07 12:59:11	15	8	1905	1	661	2186	512	74.60	34	17.73	CHANGED	lGlllllhlAaLhSpsR+.sIphRsVh...hulslQllluhhlLpsshGpshlpslusslspllsauptGssFl..FGsLs	.......lGllVllslAaLhSs....sRK..pIphRs..Vh...hhLllQlhluhhhLt..........ss..hG..t.thlpshup...shppllsaus.s.GssFlFGul...........	0	162	320	492
+3549	PF03800	Nuf2		Nuf2 family	Bateman A	anon	[1]	Family	Members of this family are components of the mitotic spindle.  It has been shown that Nuf2 from yeast is part of a complex called the Ndc80p complex [1]. This complex is thought to bind to the microtubules of the spindle. An arabidopsis protein has been included in this family that has previously not been identified as a member of this family, Swiss:Q9C953. The match is not strong, but in common with other members of this family contains coiled-coil to the C terminus of this region.	20.90	20.90	21.50	21.50	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.68	0.71	-4.23	31	294	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	249	4	211	290	3	143.80	25	32.91	CHANGED	hsp......t.sFPhLsscEIlssLps...hsls.hotcsLp+......PssphlpplYpphlphhhGh.sh-pl.t..........hhtsstpslp.sp.................hhp-slshhshh+hhpchh.ssGls.DFshpDlh+PcscRhp+hLSullNas+FREp+h...thhcctlpchcsth	.................................................................................hp......p.sa.h.LsspEIstplpp............h..sl...s....hstpslt+.............Pp..s..ph..lphlap.thlphhhsh..sh.-sh.......................hhhsstpslp..sp......................................hhpss.hsl..hshatph.pchh.ts.....sls......DFshsDlhcP..p..s..cRht+...hLSull....NFh+FREpph...thhpchhtphcp.t........................	0	69	116	172
+3551	PF04121	Nup84_Nup100		Nuclear pore protein 84 / 107 	Wood V, Finn RD	anon	Pfam-B_13117 (release 7.3);	Family	Nup84p forms a complex with five proteins, of which Nup120p,  Nup85p, Sec13p, and a Sec13p homologues. This Nup84p complex in  conjunction with Sec13-type proteins is required for correct  nuclear pore biogenesis [1].	18.50	18.50	18.60	18.60	18.00	18.40	hmmbuild  -o /dev/null HMM SEED	697	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.03	0.70	-6.85	16	402	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	252	7	259	410	4	519.90	20	76.82	CHANGED	pphp.hcLEtchW+LlptLaphR...htpppccptphc.........shsSctsh.cplhppNsplhEhpLllsWLcssh.t..h-tssslsh...os+WpNTlhslt.pht..shs.tt......shVpslDsDAPlR-pps.LcstDcpcDppla+hlFpLlhsGpl-EAhchCcpoGNhhhuhILpG...hcpa.hDPslDhphss.........................ps.pGsp++sLW++ssaplupssplDcYERAIYuhLu.Gslss.lslsts.sWEchLhsYlsphhshplEs.lhspshssp........h.lPpphht....olpplhspL.stpssclh-puccPlRll.stlILsslssllcshschL.sshss.....t..tpsalLRllTHLslFl+hlsh.tp.p.sDc..llssYlphLtttt.h-LIPhYloaL.spp.tl-tYShFLpsls-sptRc+QlElupphuLs....................lssIh+pTVppl.hp-o-pthh.sspssh.....p.clochDp+lIsulEWL.h-sp.hs-ulppuhAlhR+FLhsGKlcuh+phhpthshcslhp.Yph....t..cslssc--......sshcEllpYcshlpulctap-Wpch..........................pppp.sscpphsphpp+lpthopsshcLlhshLlt................s-sp....pctphh.plRsLYlPhllhtLHp..lhtpsp.....hhpculpLushVAsEscplYh.lF.ssG+LpEaLpplucsShl	....................................................................t.....hp.Eh.hWpLl..lh............c.................t......................................ott..h.pt..h...h.t.tst.hh.p...h.lhpWLpt.h.............................t.......................................thhW..........Th.tl...............................................hlpplDsDAshR..pt.....h..........Lp..Dp..-.thhhhhaphlRtG...h.p.c.h.chspptsp.W+Ah.lt...G............h...........ss.t.p...t...........................................................s.........p.tlW+hssh..........t....h.up..........p............t.........t...........h.......s......a..................-+Alau..hls...G.pht..t......h.....h...ls..p.....sWc-hlashhp.h.l.p..hc....t.l.t.............................................h.st.....h...........................s..h.....p...p.hh.pt..l.......t.t..p.th.t..tspp..h.phlpt........llh..t...........ph..s.t.......h.h..p...th.........l...t.........t............................................................................................................................................................................h................lRhhsHl....h..lhhp...l.t...............................................t...............p......................................t.........................l...l.......t..tYl.p.h.L........t......t.....p..hlshYss.L.st..th.......t.hu.hL.t.l..........p....p.......+............l...phh.....h...tls.............................................h..thhp.......h....p.....h....htt................................................................hp.....-...h....hpsl-Wh...h.s............t.h.c...........hh..s.hhh+ha.h......h.........tp.h...tshp.hh..h........t...h.................................................................................p........h....t.h.....p....hhth..p.h..ph.p.............................................................t.......t..t......h.......h.....hp.......t.....h..h...h.........thl..................................................................................................h..lRthhhP.hh.h.h.t........h..tt.....................................h.........tshths..lu..p...hh.................h........tt..t..p...h..hh..h............................................................................................................................................................................................................................................	1	84	143	213
+3552	PF01029	NusB		NusB family	Finn RD, Bateman A	anon	Bateman A	Domain	The NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination. 	21.30	21.30	21.40	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.47	0.71	-4.18	114	7994	2009-09-17 00:13:35	2003-04-07 12:59:11	13	8	4433	32	1709	5198	2636	125.80	25	44.18	CHANGED	pp...s....RphAhpsLhph............................htpthhpthhs...............hspp.spsahppLlhGshcphtplDthlsp.hh.shslc+hshhs+slLRlulaElha..h..clPspsslsEuV-luKph...ssppsst..FlNuVLcplt+	....................................................................................................................psRphAhpsLhph.............................ptthhs.hhs.........................ttt.h.sst....Dtsh.hp..cLl...hGshpppspL.Dthlst..hh....s..hs.l..pc..l.s..t.h..+.sl.LRluhYplha.........h.....clP......s..+....s....sl.sEuVElAKph..........uspp....s.tp...alNGVLcphh.............................	1	580	1130	1455
+3553	PF02357	NusG		Transcription termination factor nusG	Bashton M, Bateman A, Finn RD	anon	Pfam-B_697 (release 5.2)	Family	\N	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.45	0.72	-3.75	170	5994	2012-10-02 20:41:53	2003-04-07 12:59:11	14	4	4395	19	1234	3385	2659	97.80	33	51.97	CHANGED	tpWYllpstsspEp...c..ltp...pL.p....p..t..lps..................hlPhtph....ch...ps........+hp...ppshaPGYlFlchshs....s......p.....h..htl........pss..uVss...hl.......G.......sp.....Pss.......lscp	.................................................................pWYllp..sa..S.GhEp....+..Vpp................sL...c.........p....p....lps.shtc...............................hhplhlPpEcl.....hcl+...sG........+pp..hc+phFPGYVLVchshs.............D..........c..........s..Wpl......l+sT....PsV.s.G..Fl.........u...........s+......PsPl.p.t...........................................	0	418	810	1052
+3554	PF04277	OAD_gamma		Oxaloacetate decarboxylase, gamma chain 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	21.20	21.20	21.20	21.20	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.65	0.72	-3.61	96	1171	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	853	0	225	777	96	73.50	28	65.31	CHANGED	ltpultlM.lhGMuhVFlFLhlLlhhlplhupl....hpch.............ssppssssstss.sspststt................s............sscllAsIsAAlppa+pp	..............puhtlh.hlGMuhVFhh...Lh...lLlhslphhutl...........lsch........................hsc.s..s...s.s.tsts..tssss.................................................s...................................sclhAsIs.AAlppap..t.....................	0	83	144	191
+3555	PF03977	OAD_beta	OadB_MmdB;	Na+-transporting oxaloacetate decarboxylase beta subunit	Bateman A	anon	COG1883	Family	Members of this family are integral membrane proteins. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na+ across the cytoplasmic membrane, thereby creating a sodium ion motive force that is used for ATP synthesis [2].	30.00	30.00	30.40	30.50	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.12	0.70	-5.71	9	1424	2012-10-02 17:06:44	2003-04-07 12:59:11	8	5	969	0	273	1037	261	354.20	54	94.72	CHANGED	plG....................pllMllVGlhLlYLuItKcaEPLLLlPIGFGslLsNlPtuGls..shp......................................................GhhhhhaphuIsstlhPLLIFhGlGAhTDFGPLlANPKTlLLGAAAQhGIFhslhsAlhL....G..Folt-AASIGIIGGADGPTuIYloopLAP-LLusIAVAAYSYMALVPIIQPPlh+hLTTpcERKI+Mp.QLRpVS+hEKIlFPIllhllsuLLlPsAsPLlGMlhhGNLhREsGVV-RLucsAQptLlNIVTIhLGLuVGSphpADpFLsspTLhIlsLGllAFssuTAGGVlhAKlMNhFppcKINPhIGAAGVSAVPMuARVspKluhEEDPpNFlLMHAMGPNVAGVIGSAlAAGVhLthlu	........................................s..GphlMllluhlLlaLAItKpaEPLLLlPIGFGslLsN.....l.P..........u.....Ghh...................................................................................................................................................................................................sGhLhhhaphuIp.o.ulhPhlIFhGlGAMTDFGPLlANP+s.lL.LGAA.AQFGIFsollsAlhL...............u......F.oht.pAAuIGIIGGADGPTuIaluu+L....A............P.c...L.LGuIAVAAYSYMALVPlIQPPIMKhLTTccERpI+M..t....ph.....R..p.......V..S.........KpE.......KIlFPlllhllsuLllPsusPLlGMhhhGNLhREuG.V.l-.RLScTAQNtLlNIVTIhLGLoVGuphpA-pFLp.pTLtIlsLGllAFshuTAuGVLhAKlhNh....h.o..+....p....KINPLIGuAGVSAVPMAARVspKlGh-tsPpNFLLMHAMGPNVAGVIGSAlAAGlhLshl.h.................................................	0	113	184	234
+3556	PF04225	OapA		Opacity-associated protein A LysM-like domain	Mifsud W, Bateman A	anon	COG3061	Domain	This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1,2]. This is a LysM-like domain.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.78	0.72	-4.09	12	1645	2012-10-01 23:00:54	2003-04-07 12:59:11	7	7	935	1	206	836	122	83.80	37	23.87	CHANGED	sW+papVtpGsTLhQlFRcNsLsloDlsAhs+lEGusKPLSplKsGQhl+hplsspGplstLplEsssp.tlhFhRtuDGoatRsK	........+pYhVpsG-TLuplF.ppa.GlshsDlhtlAps.p..s....s.K.sLsN.L+sGQplph.ph.s.A.s.G.p..L.ptL.o..h-.s.upppph.h.asRp.ss.G.ua....h....................	0	28	71	142
+3558	PF03373	Octapeptide		Octapeptide repeat	Bateman A	anon	Bateman A	Repeat	This octapeptide repeat is found in several bacterial proteins. The function of this repeat is unknown.	17.50	3.90	17.90	3.90	17.10	3.80	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.78	-5.53	0.78	-5.51	0.78	-2.61	3	3282	2009-01-15 18:05:59	2003-04-07 12:59:11	9	83	143	0	12	2907	0	8.00	83	23.91	CHANGED	PGKEDNNK	PGKEDsNK..	0	12	12	12
+3559	PF02317	Octopine_DH		NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain	Mian N, Bateman A, Griffiths-Jones SR	anon	Pfam-B_9653 (release 5.2)	Family	This group of enzymes act on the CH-NH substrate bond using NAD(+) or NADP(+) as an acceptor. The Pfam family consists mainly of octopine and nopaline dehydrogenases from Ti plasmids.	23.30	23.30	23.50	24.20	22.80	23.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.55	47	615	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	543	5	140	433	40	146.60	33	43.51	CHANGED	lphtpshLphsLsNhsslhHPshhlhshuphc......................thp.......sch.hahpGhs...stsucllcslDpERhslApAluhph..hshtphhph..tY.......thcsss..lhchhpssp.uasslssPss.hp..........pRYlhEDlPhGLlshtuluchhGVssPhhcullphssshhGc	......................................h.shtpsllpssLpNsNs.lHPs.hlhNhGpl-.......................as............uEaslat-Glo...cpssclLcul-tERlsluctL.Ghch.........shp-s..hh......ptYh.......................tttp.-s.ps..L...pch..hpTss.sastl..s.sPsp.hc.....................sRYlsEDlsaGLshhsuluchhs.VsTPsh-ullhlusshht.p.........	0	53	95	127
+3561	PF02101	Ocular_alb		Ocular albinism type 1 protein	Mian N, Bateman A	anon	IPR001414	Family	\N	25.00	25.00	32.20	31.50	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	405	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.42	0.70	-5.87	2	77	2012-10-03 04:04:29	2003-04-07 12:59:11	10	2	52	0	48	82	0	326.40	45	95.20	CHANGED	MASPRLGhFCCPThDAATQLVLSFQPRsFHALCLGSGsLRLsLGLLQLLsGRRssG.tuPATSPsASV+ILRAAsACDLLGCLGhVIRSTVWluaPpFl-slSshNtT-IWPAsFCVGSAMWIQLLYSACFWWLFCYAVDsYLVIRRSAGhSTILLYHIMAWGLAsLLCVEGAsMLYYPSVSRCERGLDHAIPHYVThYLPLLLVLVANPILFpKTVTuVASLLKGRpGlYTENERhMGAVIKhRFFKIMLVLIhCWLSNIINESLLFYLEMQsDIpGGSLK.lpsAA+TTWFIMGILNPAQGhLLSLAFYGWTGCSLshpsP+h.IQWEohTsSAAEGsa.oPl...hPHpNPt..KVspVGGpTSDEsLShLSEsSDASTlEIHTAotSCNhpEsDsh..spG-L	.................................................MAsPpl..hCC.....h...s.s.t..hh.tFp..hatshslsSushthhhslhQlh.............h..t...........t....................................t...p...IlhhhshsDhLushGllhRSsl..Wlu.h.Pshlp.shSshst.o.claP........ss.F...CV.u.S.u...hWIQ.L.hYSAsFW.WhFCY.AVDsa.LVl..+c.SAG.hSs.ll.LYHhhsWGLAsLLslEGhshLYa...P.....S.....h..u.....p.C...E.pGLp......HA....I....PHYlTTYhPLLLVLluNPILFp+TlsuVsSLLKGR.pGIYTENERRhus.IKlRFFKIMLVFhlC..WlsNIINEoLL.FYL......EhQsDl........psssL+.l...+.s..AAhhTWaIMGILNPhQGFL.oLAFaGWT.Ghp.lth.....p.h.h.W-phssS.h.s.tt......................p...t.........p.....tpp.s-slshLSE................................................................................................	0	14	18	32
+3562	PF02100	ODC_AZ		Ornithine decarboxylase antizyme	Mian N, Bateman A, Moxon SJ, Wood V	anon	IPR002993 & Pfam-B_34796 (release 7.7)	Family	This family consists of ornithine decarboxylase antizyme proteins. The polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is degraded by the 26 S proteasome via a ubiquitin-independent pathway. Its degradation is greatly accelerated by association with the polyamine-induced regulatory protein antizyme 1 (AZ1) [1].	23.90	23.90	24.00	25.70	23.40	23.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.58	0.72	-4.57	28	301	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	183	1	182	274	0	105.80	32	48.95	CHANGED	hsssphspW......pslls....................ppsL..aV.lPp.sshspu.........................................KculhuLLEaA--p.LpssclhlshpKscs-...pssLlRohpalGFcllsss.p.............ss.......sschhaMsasl	..............................................................................s......pW.......tlhs.........................spsL...alp.lPt..ssLspG........................................sK-ulhuLLEaAEEp.Lp.....sspVhlChc+sRsD.....RusLl+sFs.alGFEllpPs.c............................................shsP........pschhFMsY.h..........................	0	47	74	125
+3563	PF02423	OCD_Mu_crystall	ODC_Mu_crystall; 	Ornithine cyclodeaminase/mu-crystallin family	Bateman A	anon	Pfam-B_1960 (release 5.4)	Family	This family contains the bacterial Ornithine cyclodeaminase enzyme EC:4.3.1.12, which catalyses the deamination of ornithine to proline [1]. This family also contains mu-Crystallin the major component of the eye lens in several Australian marsupials, mRNA for this protein has also been found in human retina [2].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.69	0.70	-5.66	11	2697	2012-10-10 17:06:42	2003-04-07 12:59:11	10	13	1722	12	903	3070	1011	299.80	23	91.90	CHANGED	scshhhhttcVthcshhs.chhshlEssFRpaups...thcpsP+lssas+c....GslclMPsh.us...hhGhKaVsuaPcNscp.GLPTlsAhhVLs-ssoG.hPlhLh-sshLTAlRTAAsuAluuKaLA.psupshAlIGsGsQuhhQscAhptlhs.lpcl+laDlcscusc+hupplpt...thplsAssssppAVcGADllsTsTsscp......sllpssaVpsGsHlNAlGuDssGKsELcs-lLtcADlaV.-a.sQs+tpGElpp.................lssccshspLu-VhsGphsGRsssccITlFDSsGhAlcDhushchla-pspsts	.......................................................................................h......................thhph...lpp.s.h.t.ths...pt........th...ts......sp......h.......h..h.........h.....p............ts..hh.h...h.MPu........h....h..........s.......s.........................h...............hGh.K.......hl.s......s...........h..s......p.....Ns....p..........p....u....h........s.........s..h.........p....u..h.h.l..L..hD.s..pT.G.hs.h.u.l.h.-ushlTshRT.A..A...s..o....u.l..A.......s....c..h....L.........A.....p....p.......s.....u.........c.........s........l........s.....llG.s.GhQA.p.h.p.l.p....u..h...t....t......l.......h.......s....l..cc...l.....t......l......a.............s........p...s..............p....p..s............p....p....h.............s........p............p....h.........p...........t.........h..........t..............h...........p.......h......h.............s.........s..........p.............s........s.........p.........c.............A.........l...........p....s....A.......D......l.......l.s....o.sTsupp...............P..l..l..p..s..........p.....h...l.............p.....s....G........s............a....l....s...s..l.G.u....p.s...s.h..p.E.l...s........s....c..l....l.....t.....p.......u..........p............l....hV....-.....h.......s.......t...h.....p.......c.....t.G.-.lh........................................................hs.t..p....t...h....h..s..-....L..u......p.l.........l........s.....G....p.....t......s.....s...........R........p.....s.........s.......c..........c.............l........o..l...........F.cssGhulpDlssAph.lhpph....s..................................................................................................................................................................................	0	225	509	735
+3564	PF02159	Oest_recep		Oestrogen receptor	Mian N, Bateman A	anon	IPR001292	Family	\N	20.60	20.60	21.80	21.20	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.98	0.71	-4.05	11	220	2009-09-12 00:57:07	2003-04-07 12:59:11	10	10	133	0	28	206	0	120.80	46	25.14	CHANGED	MYs-ps+s.....ushNY.-GA.YD.....Fssss....suAPs.apsuolu....Yhsus..ssaGssu.uthpoLsssssSPLhFlp.ouPQLSPaL.H.sG.....pQVsYYL..........-ousoshYRSSsssppQuu....cEhhouus-............+Guhuh-SsKE	....................hYs-ps+s......ushsY.EGs.Y-.....assss......ssuPl.Yuposls....Yhsus...suaGssu.Guh.sLs.osssSPLhhl..ssP....Q.LSPFl.H.tu.....pQVsYYL...........EsussshYRsssssppQuu....cEp.huoos-..............+GuhuhESsKE...................	1	2	4	11
+3565	PF04664	OGFr_N		Opioid growth factor receptor (OGFr) conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4529 (release 7.5)	Family	Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus [1].	19.80	19.80	19.80	21.00	18.70	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.26	0.70	-5.01	13	234	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	123	0	109	217	96	177.60	34	53.33	CHANGED	hh-.c.s.-h..........hNL+FYpNEIshp...PsGhaI--lLppWpss.....Y-hLEcNHoYIQWLFPlcEpG.lNhpApsLThcEIctF+psc-l+++hlcuYclMLcFaGIcLs-c+sGpVpRApNappRFpNLNcasHNpLRITRILKsLGpL.GhEpapsPLV+FFL...pEoLVptpLssl+pSuLD.YFhFsl+s+ppRRELltaAataacPptcFlWGP.chhphp	..............................................ht.....................lpFYpsch.........spGhhI-plhppW.ts...........YchLEcsHsYIQWL.FPlpE.u..hN..hh...A..LTtpElc...tF+psp...ch....hc+hlp.uYch.MLpFaGlcLt.............s.p.sG...p.....l...t...+.u...t..s.............a...p...........cR.a.p.p.....L..s.pp.pHN.............LRITRILKSLupL.GhcpapssLs+ahl...pctlhppph..s..s.lp.puslc.Yah.slh.................................p................................................................	0	34	49	73
+3566	PF04680	OGFr_III	OGFr_repeat; 	Opioid growth factor receptor repeat	Waterfield DI, Finn RD	anon	Pfam-B_4529 (release 7.5)	Repeat	Proline-rich repeat found only in a human opioid growth factor receptor [1]. 	19.50	19.50	20.90	19.50	17.20	19.30	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.41	0.73	-6.43	0.73	-3.63	4	97	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	10	0	7	144	0	21.10	66	13.11	CHANGED	uPpET.GPRsAs....Pss...DpPAE	.uPpETPGPpsAG....PAu...DpPAE.....	0	7	7	7
+3567	PF04606	Ogr_Delta		Ogr/Delta-like zinc finger	Mifsud W	anon	Pfam-B_5059 (release 7.5)	Family	This is a viral family of phage zinc-binding transcriptional activators, which also contains cryptic members in some bacterial genomes [1]. The P4 phage delta protein contains two such domains attached covalently, while the P2 phage Ogr proteins possess one domain but function as dimers. All the members of this family have the following consensus sequence: C-X(2)-C-X(3)-A-(X)2-R-X(15)-C-X(4)-C-X(3)-F [2]. This family also includes zinc fingers in recombinase proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.63	0.72	-4.30	67	983	2012-10-03 10:42:43	2003-04-07 12:59:11	7	4	577	0	122	677	13	46.70	40	45.45	CHANGED	pCPpCsspA+hRoocth..otps.....pc....hYtpCpNh.p.....CupoFsst.ohs+sl	...........pCPhCss.s.A..+sR..o.Sp..h.....osps.....+-.....+YhQCpNl.p......CutTFhohEohp+hl....................	0	13	47	82
+3568	PF01276	OKR_DC_1		Orn/Lys/Arg decarboxylase, major domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.29	0.70	-5.93	10	4944	2012-10-02 18:26:03	2003-04-07 12:59:11	15	15	2315	25	649	3284	459	379.60	33	61.32	CHANGED	PPFaKALhcYVccsphoFssPGHpGGssFpKcPAGphFYDFaGENlF+uDlssusspLGDLLtHpGstp-ApcaAA+VFsAD+oYFVlNGTSsuNKlVs.AlsssGDhVLlDRNsHKSlpH.ALhhuGAsPVYLcPs.RNsaGllGGIstppFpc-sl+ctls-ssss+s......hhAVIpNuTYDGslYNs+pll-plc+hss.IhFDSAWVuYppFt.Phhtssoshtu-..p.ps.sIhsTQSsHKhhAuFSQuShIHhK-sph......ls+cRFNpAaMMHsSTSPaYPlhASLDVAAuMhcGsuG++Lhp-slcpulchRKpl........lssuphFcPatPplVcspp....................ha.hcssppWHuFcshsspphalDPsKlhLpTPGhs.csG-hc-hGlPAslVApaLcEp.GIlsEKoD..sILFLho.GtscsK	.............................................................sPhhcALh.p.Yscp.t.phsF...s.s.PGH.....ps.Gp.h.a.p+......pP.sGp......ah-a...aG....c..shh+s.Dls...shst.L.......GsLLpH.pGs.h.t-A.pchsA+...sF.sA....-....+o.........ah..VlNGT.SsuN+slh..us......h......s........s.G........-........h.l.L.lDRNsHKS.lhp...uLh..hs....G..u.p.P.l.Y.l.css..R..........Nt.h.G.l.l....G.G..Is..t.p..php............p..hl..p...ct....l.p..c.....s.....s.s.s..ps.....................hsl.ls.p..s.TY..D..Ghh..Y...N...sc..t....lh...c...h....l...p...p..h..s.........l..hF..DpAWsuat..p.Fp....s....h.....ht.s.p..........s..htu-.........t..t.....hl.hsTQSsHKhhuuhS.QuShIHl+ss.....................hsc.cph....N..p.A.ahhHsoTS...PtYslhASl....D.su.sphhcut..sG...........c.pLh.pc.slchu.............lc.hR+tl................sps..hhh...cs..a............lss...........................h.a..h.....s.s.....t...tWH.u.F..t.s..h......t.t.......hlDPhKlhlhs......PGht...pG.ph.p.p.....GlPAs.ll..s.t.aL.t.c.p.Gllsp+ss..slhhLho.u.s.t............................................................................................................................................................................	1	197	374	507
+3569	PF03711	OKR_DC_1_C		Orn/Lys/Arg decarboxylase, C-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.20	20.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.69	0.71	-4.12	32	4706	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	2279	25	600	2682	216	119.40	31	18.69	CHANGED	LPslapppPchYcshsl+-LCQphHcha+ppslhpLppchF..sshPchsMsPpcAatchl+sclEhVslc-h.GRluAphhLPYPPGlslllPGEha...upsllcYhhhLp-hhspaPGFps-IpGlahppcsst	.............................................................hPplhtt.......Yt.th.tlppL.spthath..hh..p....s.......t..h...........th...a..........p.h.hP..p...h.hh....s....P..pp.A..a.....t..l...c.s....p....sEhV..slc..c....h..GR.......l.......u.......AphllPYPPGlPllhPGEhh........s.ps.ll.cYlt.h.Lp.p...h..thhP.G.Ft..-hpGh.......s..........................	0	176	343	466
+3570	PF03709	OKR_DC_1_N		Orn/Lys/Arg decarboxylase, N-terminal domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Domain	This domain has a flavodoxin-like fold, and is termed the "wing" domain because of its position in the overall 3D  structure.	28.60	28.60	28.60	29.00	28.40	28.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.18	0.71	-4.03	82	2923	2012-10-01 22:20:39	2003-04-07 12:59:11	10	5	1008	23	274	1331	55	108.10	28	15.04	CHANGED	hpttshppltptlpt.pshplltssshcch..hh..tscluulllsh-................phtpsllpplcppshplPlFlhsct...sspplsschlppls...thhph.hpssscahApplppAsppY	........................hpttslccLtssLst.pshpllhssspc-h..hhp.psclsul..lhshs........................c.stsllsclcpp.s.pl...PlFhhssp....sshcl.s.s.shhphl.....tahph...h.sss-.lAtclcpssscY................................	0	34	100	179
+3571	PF01277	Oleosin		Oleosin	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	20.70	22.80	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.49	0.71	-4.53	15	355	2012-10-03 03:08:05	2003-04-07 12:59:11	12	4	58	0	111	359	0	107.80	35	54.63	CHANGED	SosQlLsllsulPlGGsLLsLAGLTLAGTlIGLsVATPLFVIFSPVLVPAslsIGLAlTGFLsSGuFGlTuLSSlSWlhsYlRtppssss-pl-hAKtphp-hstasGpKs+-hGp+h	...................pllpslsusssussLLlLuGLTLs.GolluLsluTPLhlIFS.PlLVP..AsIsssLlssGFluuGuhGlsAl.uslsWlh+ahpu.....t.p..s......h....s....th..p.hh...........................t.......................................	0	25	71	86
+3572	PF02191	OLF		Olfactomedin-like domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.80	20.80	21.20	21.20	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.73	0.70	-5.11	40	1087	2009-01-15 18:05:59	2003-04-07 12:59:11	11	39	91	0	497	860	0	245.70	37	33.48	CHANGED	sLhslupPhhl.....+pssp...phGuWh+Dsh.....tssc+lahhsshsss...p..lhcapphpsF........htsptspp.........hpLP......hshpGsGaVV.Ys.GulYYpct............popsllKa-Lsspslsspp.LssA.uap..s.hsYthuuhosIDlAVDEpGLWlIYuTppssGp.....IVlS+LsPpoLpl..ppoWsTsh.KpssuNAFhlCGsLYsscohstps..........scIpYsaDTp..ssppp.tsslsFpppapthstlcYNP+-ppLYsWssGa.lhYslphtp	................................................................................h.LpslspPhpl.....ppssp...phGuWh+DPh......pssc+l..a...hh.sh.h.tp....pplhEY.pshpsF............htuptsps............................a+LP.......athpGTGaVV.Ys.GulaaN+t..............popsIlKaDLco........ch.........hs.s...............pt...............hlssA..sYc....................s..p.P...Y....p..W....u...GpoDIDLAVD.Es.GLWlIYuTpp..s..s...Gp.......IVlSpL....sP.hTLpl..cpTWc.T.s.h.sK.puAuN.AFhlCGlLYslcSh.psp..........sclpYsYsTp......ps.pt.p.h......ss.ls.F.......NpYp.aluhlDYNP.+DptLYsWsN..sa.ltYslph...................................	0	66	116	258
+3573	PF00691	OmpA		OmpA family	Bateman A	anon	Pfam-B_166 (release 2.1)	Family	The Pfam entry also includes MotB and related proteins which are not included in the Prosite family.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.65	0.72	-3.58	84	17270	2009-09-13 10:58:36	2003-04-07 12:59:11	15	239	3418	100	4376	13311	4143	97.50	27	31.23	CHANGED	hFs.sssp.l..s.......spspptLp....plu..phlp...........t........ltltGa.....................sss........hss....tpt....NhpLStpRApsVtph.Lhp.tG....ls.sp...cl...h..puhGp..spshssssssp.spthp.........R	..........................................................hFshspup..l......p........sp..s.p...p...h...Ls..........plA.....phLp.........................p.....h.....lpl.p.GH.....................................................................................TDs............................pGs......pph.........................NhpLSpcRA....pu....Vtph...Lhs...tG...................ls..ss............+l......ps.....hGhGc.......ppPl..ss.s.s..s..tt..spt.N....................................................	0	1365	2716	3618
+3574	PF01389	OmpA_membrane		OmpA-like transmembrane domain	Bateman A	anon	Bateman A	Domain	The structure of OmpA transmembrane domain shows that it consists of an eight stranded beta barrel [1]. This family includes some other distantly related outer membrane proteins with low scores.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.28	0.71	-4.77	13	1301	2012-10-03 17:14:37	2003-04-07 12:59:11	12	16	841	9	132	2219	115	165.60	47	47.12	CHANGED	Pp-NTaYsGuKsGWupaHDss.................psstssHcNshshGsFGGYQlNs.....LuhELGYDahGRhsh+upst..........................sstapsQGspLosKhuYPlsDsLDlYu+lGuhlsRuDsK....tpu.t.......tpsHDstsSsLhAsGlEYAlsPElAsRLEYQalsslGchpstsp............pPs.uslolGlSYRFGQus	..............................................................................................................................................................................................PpsNTaYs..Gu...Kh..G..W.u..p..a...c...Dss....................................sst.ss.c.c..s...p..l..u..h.G........s..F...u.....G......Y..Qh..N.sa...................luh..E...h.......G.....Y....D........a......L.....G..Rh..s...h....c.u...p..........................................................ss.s.a..c..A..p...G.....l.....p.....L......s.....s....K..h..u.........Y......P..........l......s...-....c.....L...Dl..Y..s.....R..L..G...G..h..l....W....R......u.....D...s...+...s.t..............t.........................hpsHD.T..GVS..Pl...h.A....uG..lEY..A..l..T.....s..-lAs..R..L....E...Y.Q....W..s......N....N...I...G...D.sp.o.h.Gs............................RP..D...s..uh....lS....lGlSYRFGQs...................................................................	0	12	44	91
+3575	PF03938	OmpH		Outer membrane protein (OmpH-like)	Bateman A	anon	COG2825	Domain	This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterised as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery [2].	29.20	29.20	29.20	29.20	29.10	29.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.14	0.71	-4.29	151	2754	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2008	6	700	2002	1837	154.60	21	89.11	CHANGED	lslhh.h....hss....................ssst...Ap......................+luhlDhpplhpp..sttcp....hppplppp....hp...phpsc..............................................................................lpphppcl...ppthpphppp..tt.........thsppttppt..pp..chp.....................pptpchpphppphp...pc...........................lpppppp........hhptlhpc.l...ppslpplucp....pshsllls............pss...............llas..ss..sh..DlTscVlptls	...................................................................................................................hh..hhh..h.hss.............sstt.......Ap.........................................Kluhlshpplhp.p..h.st...tps....spppLcpc...........hp...thts-...................................................................................................................................................lpph.ppcl...........psthpchppp....t...........................hhstsptpch....pp.......-lt................................ptppph..ppt.....tpthp........pc...................................htpcppc........thpplhsc..l...ppulcplApp....pshsllls...........tss.......................lhYs..ss....sh...DITscVlcpl......................................................................................................	0	256	489	615
+3576	PF01278	Omptin		Omptin family	Finn RD, Bateman A	anon	Prosite	Family	The omptin family is a family of  serine proteases.	20.10	20.10	20.40	20.40	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.87	0.70	-5.32	7	512	2012-10-03 17:14:37	2003-04-07 12:59:11	15	3	418	9	44	269	1	275.50	56	92.86	CHANGED	uos...s.hsP-shosshSlGsLuGKo+EhVYcs.-sGRKlSQLDWKhpNsAIl+GslsW-.hshlolsApGWToLuStuGpMsDhDWhsS....spss.WTDcSpHPsTplNYANEaDLNlKGWhLpsssY+lGlhAGYQEoRaSaTApGGSYlYsssu....phGsFPssh+sIGYpQ+FphPYIGLsGsYRhscFEhsuhFKaSsWVpApDNDEHY..hRclTFR-KspsppYYusulsAGYYlTssAKlasEhoas+hpptKGsTplhDp.SssoushsssuAGIpNhNahsTAGLpYpF	................................t...h.shoP-slssslSlGsLsGKo+EhVY.s.-s...GRK.lSQLDWKhpNs.AIl..+Gsls.W....-h.......h.s.....l..olsA.tGWTo.L.u.S..t....uGpMVDpDWMsS.......spPG....WTDcSpHPD.Tp..lNYANE...aDLNlKG.....WLL.......ppsNY..+..lGlhA....GYQEoRaSaTA+GG..........S...YI.......Y..........ss...tc.....................IGs..FP...s...G....R....uIGYpQRFcMPYIGLs.G...sY.R.h.p.D.F.EhsuhFKYSsW..Vp.ApDN...DEHY.................h+.+......l..TaRpK.s.cs.ppY.YusulsAGYYlTsNAKlasEhuas+hs.ptKGsTplhD+.sss..Tu.autsuAGIpN.NahsTAGLpYpF.............................................................................	0	10	21	29
+3577	PF03922	OmpW		OmpW family	Bateman A	anon	COG3047	Family	This family includes outer membrane protein W (OmpW) proteins from a variety of bacterial species. This protein may form the receptor for S4 colicins in E. coli [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.23	0.71	-4.64	9	1853	2012-10-03 17:14:37	2003-04-07 12:59:11	9	3	1309	10	354	1343	105	183.40	37	85.72	CHANGED	psGsahl+uthspVhsssusshh.......hsssschs...sssssp.sLohTYhhoDplusEL.............luuT.hpHplssps...sssshluc...sphLPPTLhsQYa..hsssush+PYlGAGlNYshFaspphsss....thoclKLcsuaGhAhplGlDhhls.cshhlNhsVhhhhlcosAshp....sussthcscV+LDPWVhhhGlGa+F	...............................................................................................tGphhhRst.hsVhPspsussh................ssh.sshs........lsss.spluLohoYhhTD.N.lulEL............................................luu...o..PhpHcls..s.s..................s.....h.G..c....lus..........s+.pLPPT..Lhh.Q.Ya..hhsss..u...chRPYV..G..s..Gl...NY.Th.......F.as.p...p.hsss................................uh.o.sl...p...l..c...s.S.aG.s.A.s..p..l..G..hDYhls...cpWhlshsVhYh..sI.cTsushp.............hu..s...s......p......t............p.s...s..l+..l..DPa.V.hhhusGYRF.................................................	0	69	155	256
+3578	PF03532	OMS28_porin		OMS28 porin	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.70	20.70	20.80	48.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.74	0.70	-5.31	2	39	2009-09-11 23:15:34	2003-04-07 12:59:11	8	2	24	\N	1	27	0	167.90	72	99.15	CHANGED	KIFSNLIINGLLFGFVSLNVFADSNNANILKPQSNVLEHSDQKDNKKLDQKDQVNQALDTINKVTEDVSSKLEGVRESSLELVESNDAGVVKKFVGSMSLMSDVAKGTVVASQEATIVAKCSGMVAEGANKVVEMSKKAVQETQKAVSVAGEATFLIEKQIMLNKSPNNKELELTKEEFAKV-pVKETLMASERALDETVQEAQKVLNMVNGLNPSNKDQVLAKKDVtKAISNVVKVAQGARDLTKVMAISLY	...........KhFtNLIIsGLLFGhVsLNVFADSNNsshlp.pSNVlEpsDQKDsKp........LDQKDQVspuLshIsKVTEDVosKLEtVRESSLtLVESNDAulVKcFVGSMSlhSDsAKGsVlASpEATlVAKhSGhsAEsAN+VVEhSKKAsQETQKAVSVAsEAhFLIEKpIM.NKSPNNKELELTKEEFAKVEpVKETLMASERALDETVQEAQKVLNhlNGhNPSNKDQhlAKKDVtKAISsVVKVA............................	0	1	1	1
+3579	PF02462	Opacity		Opacity family porin protein	Bateman A	anon	Pfam-B_2356 (release 5.4)	Family	Pathogenic Neisseria spp. possess a repertoire of phase-variable Opacity proteins that mediate various pathogen--host cell interactions [2]. These proteins are integral membrane proteins related to other porins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.62	0.71	-4.27	4	799	2012-10-03 17:14:37	2003-04-07 12:59:11	10	2	118	1	25	2965	35	133.70	47	70.81	CHANGED	sGYchs.shRlAsDYT+YtKhsus...............sosl+Gh.....................LGhSslYDFDTtSchKPYlGsRVu......................oN.thchossA+h.thcu....sScp+lGlGVlAGVpYclTsNlsLssGhcYNplGph.psopVpshtspsGlRapF	...........................................................................................................VGYD.FG...s.....W.....R...I..AAD....Y...A.S.....Y.R..K...Wsss...............................p.............s..p......p...l..ptp.ssstpp.p.pp.................................QtNGoFHAsSSL.G.L.S....A.I...Y....DF.K..L..N..D...K.F...KPY..I..G..A..R..V..A...................................................................................hs....ps....+....h..p....s.....c....o....s...p..s....t..p..p..t...................................................................................................................................................................................................................................................................	0	4	9	13
+3580	PF01160	Opiods_neuropep		Vertebrate endogenous opioids neuropeptide	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	21.00	21.50	19.60	18.40	hmmbuild  --amino -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.01	0.72	-4.20	31	202	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	67	0	73	181	0	44.50	39	20.36	CHANGED	-CspDCutCuh+..spps.plNsLsCoLECEGcLsosctW-tC+clLpht	...............-CtpcCshCsh+..st...s.slNsLs.CsLECEupl.ssp..W-hCpphLp.h...................	0	3	11	26
+3581	PF04966	OprB		Carbohydrate-selective porin, OprB family	Bateman A	anon	COG3659	Family	\N	19.80	19.80	19.80	19.80	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.98	0.70	-5.31	48	1348	2012-10-03 17:14:37	2003-04-07 12:59:11	7	5	568	0	433	1321	465	361.60	17	76.71	CHANGED	cpshthssphthshshDLp+lhGh.cusphphs...hhpppGpslsss......hsshtshpplhGtt.......................................pthRLs.phhhppphh....................sspLsl+hGphshsspF.......................hssshsspFh.....shuhsusssss.........hsshhhsaP...hushusplchp.ssp....hhlpsGsacssssshss.............pGhsh........psssGshlssEls..ap.t......................................httsthsGpYclGuahssuphsshh.shsh....h.....................ts..spptp......................................uptGhahshpQpltpsss..........tsLslFupss............husssssh.....hsttlshGlshtGshtsRspDslGluhuhtphsspsptttt.ht..sh..............tssEhhhElaYphplsstlslpPslQYlhpPuss...........sphssuhlhG.l+hphsF	............................................................................................................................................................................................................................t.t..tph..thph-LtthhG...h....pshphphs.....hhp.t.ps.h.shosp.................s..ts..h...s..h..pt.hh...utt...............................................................................................................ph.+Ls...phhhp.p.p.h................................tspL..pl..cl.Gphs.hsp..a........................................................s.sh..t.spFh.........................shsh.s.s.s.s..sss..........................hst.hh...s..aP.......tthus...pl.....ph..p.sst...................hhh.p.sGsa.p..ss..ss....s.hps...............................puhsh........................ttssGh..hh...hchs......at.t......................................................................s.s.th...sG.p..a..phu...s......h.h..s.ssp.h.s..sh.......h..s...t.h...............................................................s..pt.tp.............................................................................s.p.huhh.hshp.Qtlht.s.................sl.slhu.phs................................hsss...s.s.sh..................hs...h.thshGhsh..tu..h.....tRss....Dp...lGluh..u.h.t.h...ssp.h....p....th...t..t.................................pssphh..hEhhY..phpl........s..s........t..lp..lpPshQalhpP..uts.............pth.sssh..lhG..l+sphpF...............................................................................................................................................................................................................................................	0	101	252	353
+3582	PF03573	OprD	Peptidase_S43; 	outer membrane porin, OprD family	Griffiths-Jones SR	anon	MEROPS	Family	This family includes outer membrane proteins related to OprD. OprD has been described as a serine type peptidase [1]. However the proposed catalytic residues are not conserved suggesting that many of these proteins are not peptidases.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  --amino -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.97	0.70	-5.68	47	2107	2012-10-03 17:14:37	2003-04-07 12:59:11	8	5	748	29	364	1637	75	371.00	27	90.15	CHANGED	tGFlEDSpsslphRNaYhNRDa+ss......ss.t...........upp-..EWuQGFlhsapSGaTpGsVGFGlDAhGhhGlKLDuGtuc..uG.oGl.......LP......hs.sD....Gc..ssDcau+hGs.ssKhRlSpTpLKhGc.hhPshPlltssDuRlLPpoFpGstlsSpElcsLsLpuGphspss.Rssoshc.chsh.ht........sussucphsasGGsYphs.cphosuhahucL-DlacQpYhulsashPluts.sLssslphacocDsGp....u....................thG..plDNcsaSshhuhph.GuHohsluaQ+ssGDssasYls..............G.ssshaL..sNsh.huDFssssE+SWQlRYDhsFushGl.....PGLoaMsRYlpGcslcssss....................s-G+..-WER-h-lpYVlQSGshKsLul+hRpuohRssh..........sschDEsRLIVsYslsl	........................................................................................................uFl-Dup.hshthh.h....hpR.Dh+ss..................st...............thpp......chsp..u...hhLs...apSG..a.......st.......s.......h.......l.......G...hG..lDs..huh..hulcLsssssp.....us...sth................h..............p.....ss.....tt........scsa.......u.......c.........h.G.....s.....s........sKh..+..h....u....p..o....h..l..........+.........h..Gp.h...........s.p.h.Ph...lhss.stRhlPpoap....G....s....t....h....s.s....p....-.h...s......s...L..shpshh....hs.c.hpt............sp.s..s..h....c....chh.ts....................................tsspscth..p.hhGu..p..Y.p........h.....s...ss.h.s..hphh.huphc-h.........hcQ...haht.h.sap..h.s..lu..s......sLsssh..p.ha....tsc....-c..Gs......u...........................hss...th...D.sp....s..a..s..tt..h..o..hsh...t..s..t.....ph....t..h....sa..t..p.....s.....s....G...sp...u.....a....hht.................u..sssha.h..........hu....D..F.s.s...ssE+oh......h..t..hsY-hts.h.s.l.....P..GLs.hhs..p..Ylh...G.shcsssh......................tphc..ch..thshphsYslQs.G.......hKshth+h+...s.hc.t.......................................................................................................................................................................................................................................................	0	43	136	258
+3583	PF03169	OPT		OPT oligopeptide transporter protein	Mifsud W	anon	Pfam-B_3048 (release 6.5)	Family	The OPT family of oligopeptide transporters is distinct from the ABC Pfam:PF00005 and PTR Pfam:PF00854 transporter families. OPT transporters were first recognised in fungi (Candida albicans and Schizosaccharomyces pombe), but this alignment also includes orthologues from Arabidopsis thaliana. OPT transporters are thought to have 12-14 transmembrane domains and contain the following motif: SPYxEVRxxVxxxDDP [1].	24.50	24.50	24.50	24.90	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	624	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-13.07	0.70	-6.09	45	2900	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	1215	0	1473	2844	385	534.50	19	86.15	CHANGED	phThRuhllGlllsllhussshhhuh+sshlshsslsstlluasls+hht..................................................h.hs.stPaohpEpsllpshus....uuss.h....shusshlhs..thhah..................tpph...shshtlhhshssshlGhhhushlR+hllhs..sphha......Psuhsssplhpshcpsp...............................................................p..hpph+hhhhshhsuhlatahsthhF.hlush.uhh.h........sthshshhhhths.........hshDashhh..lusshlsPhhsshshhhGslluahllhPlhhat.sshhsshhs.......h...us..............tshhhshtta.shushhhuuhhsl........hthssslspslhhphpsht...............................................t.......p-.ppphhpphc-.....................lP.hahhsshl.lshslulhhhhhhh..hphsh..........hulllulhluhlhshssuhhhulosh....ssul........shls.llhuhhhsup.................slAslhhsuhshsshupAtshhpDLKhGahh.tssPRthhh....sQhlGslluullsssVhphh..spt.hhss.........shshss.spshhhuulhhulhus.........shsahhlhhuhlhGhlhshlthhh....................tph.hPt..................lhhu.....lshhhssphss.......shhlGslhthhlc+...............................httthhpch.............shlluuGLssGtulhulllhhhh	..............................................................................................................................ThRsh.hlG......hlhshlhsshsh.....hhs.h+..ss.h....sslss............t..llu..hsl...hphh..........................................................................ts.hshhE.ps..................hl..phhus.......uuts.............hu.........s.hlhs......s.h...hhh.........................................................htth.....shh.hhhh..s...hss...t.....hlG..hhh..sh..............hR+.........h..h........lh.........sph.a....................Pp......shssstlhpsh.cptt................................................................................................................p..thphhhhshh...............hu..hh..ath........s...h..h.h...hs.....th..sh...................................h..h..t..h.......tht..........................hshsh...s.hh....lGs...s....h.l.................hs.hh......ssh.shhhGh..hls.ah..l..hhPh..h...h.....h..h..........h.........s............t....hs...................t...........................................phh..h..s...h.tah..sh..uhhhhs....u..h.hsl............................hthht..hh.ps...hh...t...hp..thh...................................................................................................................................................s.....t.t...p...h..t.t...pp..........................................................................l.s..h.hh.h.h.hhl.....h.hhh.h...h.h.h..h.....h..h........h....hsh..............hshl.l.shhluhh....hshs.suhh.huhss.......hsuh...................shl.s...hl.hu.hh.h..s.......................................shhslhhss............hsh.ssss....usshhpDhKhG.....ahh...ths...........P...tt..h..................uphlGshhushl.ss...........lh.hh...............shh.hs..........................s.shs..s.sp.shhh...........s.slhhulhss............................................sh..a.th...l...hh...shhhGh.hh.lhs.hh..................................thh.hP.......................................lhhu......hs.h.h.h.s....t..hs.h....................h.hl.Gh.h....ht.hh...hp...c.......................................................................hh..t.thht..ph.................................................................shlhuuGL.sGtulhullhhhh.h..................................................................................	0	399	892	1266
+3584	PF04069	OpuAC		Substrate binding domain of ABC-type glycine betaine transport system	Kerrison ND, Finn RD	anon	COG2113	Family	Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation.  This domain is often fused to the permease component of the transporter complex.  Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis [1]. The family member OpuBC is closely related, and involved in choline transport.  Choline is necessary for the biosynthesis of glycine betaine [2].  L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.64	0.70	-5.04	87	7137	2012-10-03 15:33:52	2003-04-07 12:59:11	7	15	3034	55	1357	6630	3203	253.50	21	72.82	CHANGED	sslslusts.as-shhhuplhtplLcpt.Gh.sschsshss.ss.hhsul.ps..G-lDlhs.tahsss......................hpthtc.thtpphshhh.s.shhhssp.uhsVsphhsc.............sl...polsDL.........tphss............shsschhsts.sGhs.......shhcsY.Gl......hh..ushtsh.s.....tlhpAhcptc.shlshsasscshhsph....c.lhhLc..................................Ds...+shhss.....tpltslsp.pshtcctPp.ltphLpplp..l.sscphpplttplst.pttss..pp.sAppalpp	............................................................................................................................slplusts...h.sE.st..h.h...s...p..l...h..p...p..l...lE...pt...Gh...ssp...h.h.s..h..s..s.......sh.hapul..ts........G..-....lD.l.hs.pas.sss.......................................................................hpt.hp....p...ht.t..p...h.thhh.h.s....shh.h.s.s.s.h...u..l..sVspth..up....................................t....sl...polu.D..L.........................................tchtt................shsschhs..pt...sGhs...........sh..h..c..s..Y...sl...............h...s.s...h.s.sh.s.............hhhpAh.pps..c...hsshhs...a.s...s..c..s..h.....h..s..p..h........c..l..t..h.Lp..........................................................................................Ds.......cp..h..hss......................hp.s.s..s.lsp....cs....hh...c.c....p.Pp..ltp.h.l.splt.......l.ssp...phpphphpl...ps...ptt...ss.....pp...sAcpalp......................................................................................................................................................................	1	350	775	1085
+3585	PF01718	Orbi_NS1		Orbivirus non-structural protein NS1, or hydrophobic tubular protein	Bashton M, Bateman A	anon	Pfam-B_1752 (release 4.1)	Family	This family consists of orbivirus non-structural protein NS1,  or hydrophobic tubular protein. NS1 has no specific function in  virus replication, it is however thought to play a role in  transport of mature virus particles from virus inclusion bodies  to the cell membrane [1]. Orbivirus are part of the larger reoviridae which have a dsRNA genome of at least 10 segments encoding at least 10 viral proteins [1]; orbivirus found in this family include  bluetongue virus, and African horsesickness virus.	25.00	25.00	111.40	111.20	18.80	18.40	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.23	0.70	-12.87	0.70	-6.48	7	185	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	65	0	0	167	0	452.80	51	99.24	CHANGED	MERFlRhFplsuptA.tlRhhtsISspWTCSHh+RsChhpGhCs+QpFpps.s.tshcpt-hstAp+llclAtphhhsRpclWhpshpshsp.hs-phtpchppshppL.-sYppSshpcchtshhphpcssp.lhhDDShShh.hhYhPhspss.spssplsRhtphhhsFYsspsscs.hl..pp.thcthhsphhp.stctlspC.aTGsptsl.tlhahP.phhshhss.p.sphlhRhsphDlphIhphsh+c.sRlhhQRFGhcssu.sslaphhlt+lch.sh.pollpt+h.....psWpphhlPhlLhRthhhthhs.p.hhsahpschsCQsCaltptsphcplhllDsRsuElsG...ssshths+hhcHhDs-.ph.pht-LptsEhlsR.usHWhshsChoot-AlhlThh.IHRhlRGsGlhss.thp.uh.hLARshLhWt..ssttpSslFRLhCashhthpspspGphhsWtDLGsFhchlhcspcLs.s.sEchasshhchs.....LhYhpp....h+hsshs...tsthpptplhpllpt.hsh	....MERFLphaslsG-hANAsRhFhsISPQWTCSHLKRsCLhNGhCs+Qp.F-cs.h.tAT.Dsp-.tpAh+LV-LApcAhhDR-TVWLpshKshsp.hpppl-tphccpsspLh-s....YppSGhh-Eh.p.pthssspR.lhlDDShShhPYhYlPhppGp.hlssshlSRatQluahFYsssssDc..aIs.s.hGlRttpsplK+tlEcplss..CPYTGhpGRlhpVhaLPlphhshhchp-.Apph.RhAuhshp.hh+s..Gatct.RhlpQhFuh.sssEhslHphMLh+hch.scspolVphRhhpsGs.sWpoWhlPhhlhRpuh.t........p.E.llsaM.c+KhTCQ.lC.ahhc.t.h.ThsVlDs+hu.ELsG...soshhhs+h..HssNc.pV.ps+.LhhsE.ht+IsDHahhppCaTstEAlhsTAIpIpR.IRGsG.Wss.happuhhhLsRlllhW.h.shspRSAlhRLhCFshaGhtPpAcGph.DWssLGoFhc.lLcG.-Ls...EDEp.sahoMhcMs.....hhasp+....s+hsshs...tsshE.tpVhplsth..p............................	0	0	0	0
+3586	PF01616	Orbi_NS3		Orbivirus NS3	Bateman A	anon	Pfam-B_1029 (release 4.1)	Family	The function of this Orbivirus non structural protein is uncertain.   However it may play a role on release of the virus from infected cells [1].	25.00	25.00	47.30	47.10	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.13	0.71	-5.34	11	375	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	70	0	0	339	0	202.30	56	91.79	CHANGED	p-holhsh.....PPhh.soAPshs..........thpshuLslLspAhossTGAotspKcEKAAauuhAEAL+D..stslRpIKhpVsppsLscL+t-Lpsh+R+psll+hlhhlsuslslsoohlsuhophssplpphhptp...............hlshslpslsLhsTshhlhsu+hppplppplcRsK+-IhKRcoYssAAphshsuss.........thsLpsschut	.............s.............pP....PpYsPSAPhPS..........oMPTVAL-ILDKAMSNTTGATpsQKsEKAAFASYAEAFRD..DlRLRQIKRHVNEQlLPKLKo-LuGhKKKRAIlHhTLLlAAVVALlTSlsTLoSDhuVs..hKhNsTps-ls............ahKsLsshlGllNLGAThlMMsCAKsE+uLNQQIDhIKKElMKKQSYNDAVRMSaTEFS.........SlPLDGF-hP.h...............	0	0	0	0
+3587	PF00898	Orbi_VP2		Orbivirus outer capsid protein VP2	Finn RD, Bateman A	anon	Pfam-B_1525 (release 2.1)	Family	VP2 acts as an anchor for VP1 and VP3. VP2 contains a non-specific  DNA and RNA binding domain in the N-terminus [1].	18.40	18.40	18.40	18.50	16.10	17.90	hmmbuild  -o /dev/null HMM SEED	946	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.48	0.70	-13.27	0.70	-7.02	25	468	2009-09-11 12:16:15	2003-04-07 12:59:11	12	2	67	0	0	373	0	558.40	24	90.95	CHANGED	uLLs+YPLAIplsVKl-D.GG+HsllKIPESDMIDlP+.oIlEALsY+PtRNDGlVVPRLLDITLRAYDsRKSsKsA+GlE.FMTcs+WMKWAIDD+MDIQPLKVoLDcasS.VNHQLFNClVKAcSANADTIYYcYaPLEsusK+......CNHTNLDLLRSLTssEhFHsLQGAAYuLKoTYELVsH..SERcshSEoYpVGspcaIpLpRGT+IthpGpsYE+FlSSLVQVllcGKlP-cIRsEIApLNc...I+sEWhsAsYDRs..+IRALELCKILSsIGRKMLDs.....pEEPKDEMsLSTRFQFKLDEKFh+sDpEHlNIFcVGusATD-GR.FYALIAIAATDTQpGRVWRTNPYPCLRGALIAAECcLGDVYhTLRpsYcWSLRP-YGp+ERsLEsNK.YVFuRlNLFDoN.LuVGDcIIHW+YElhps..+ETTaDcGYhCsppt..s.DDELlCclDED+YKEMhDRMIQGG.WDQERFKLHsILT-P.NLLTIDFEKDAYLssRSELVhPsYYDKWIsSPMFNARL+Is+GEIAThKuDDPWssRuV+GYIKssuESL-YsLGsYYDLRlpLaG-sLSLpQcQS..AVFpahuQpDDFusLTchppGtsVCPHS....GGshYTFRKVALhlluNYE+LsPsLHEGhEccpYhHPu...lsstac++VLEM+DhSQL...ICFVFDYIFEK+pQLRss+EARhIlYLIQssoGstRL-VLccsFPNFhc+lhsL+-lKplpDLNVIN.FhPLlFLVpDNISYhHRQWSIPMlLFDcs.IRLIPVEVGAYANRFGhKSFhNFhRFHPG-uKK+QcADDsHKEFGslsF-YYssTKISQGplcsPVVToKhDsL+lHlASLCAGLADSlVYTLPVAHPKKsIVLIIVGDDKLEPplRSEQIVs+Y.aSR+HlsGlVSIsVsQsuQL+VHopGIs+HRlC-KsILKYKCKVVLV+hPG+VFGNDELMTKLLNV	..................................................................................................................................................................................................................................................................................................................................................hhhp.t.s.....-sh.h.p..sht..............Hs..thh.phh..t...h.pthsYtht.p.hplhsh.......sp...tphp.....c.....h.s....p..h..t..h.....+th.h........tt.tthphhh.......tshs.......hphph..........................t...............tp.......h.plp................I..ptp....http.s....p....p.sp.lpthht..hh.p.......p.tsts.p.shp.+Fphpl.tph...pstch..I.ht..tttthsp.t+.FhsllhlsssDs.pttha....h.hlhhhh...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.ptt....hh....p...hphhhus.CtGht-.h..hhPhtpP..shlhh.h.s.......t.t.h..hh....p...thh.l.lt...............tt.................................................................................................	1	0	0	0
+3588	PF01700	Orbi_VP3		Orbivirus VP3 (T2) protein	Bashton M, Bateman A	anon	Pfam-B_1622 (release 4.1)	Family	The orbivirus VP3 protein is part of the virus core and makes a 'subcore' shell made up of 120 copies of the 100K protein [1].   VP3 particles can also bind RNA and are fundamental in the  early stages of viral core formation [1]. Also found in the family is structural core protein VP2 from   broadhaven virus which is similar to VP3 in bluetongue  virus [2]. Orbivirus are part of the larger reoviridae which have a  dsRNA genome of 10-12 linear segments [1]; orbivirus found in this family include bluetongue virus and epizootic hemorrhagic  disease virus. 	25.00	25.00	48.40	47.90	23.50	19.20	hmmbuild  -o /dev/null HMM SEED	890	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.54	0.70	-13.39	0.70	-7.12	7	204	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	66	2	1	161	0	531.10	67	98.12	CHANGED	ssuPYLcGDplpsDsGPLLSlFALQEIhpKVRpsQtchtstupEl-sshP-VppIlssl+sLtcp+sY+llppPshSaRaIshQSp-RhhRVsoaaERhSplG-shcpp-PhcFhssllc+V+alRscGuFlLaslsT+.hcGtEls-s-sLGV-hpshhssLsA.sRthlQstLsuhlIpNtpsscp.VDVa.GACsDslYRlHstLpuYlEssQhtphRpulsWLpphGppKRIpaspcaLTDhhpuDTIalLohpLPsNPpVIW-VPRsuIuNLIhNhALslPTGpYluPNPRIsSITlTpRITTTsPFA.LpGhsPTAtQMsDVRKIYLALMFPNQIlLDl+.-PGHplDPllphVuGVlG+LhFoaGPRhhNITpsMAp.LDhuhscaLhaMhssRhplpaGsoGcPLDFhI..GppQaDCNthtss.pTGpGYNGWu.VDs.tccPoPYsHVpRhIpYhshDScElID.RhhG.shsY.happMhchLltAG+ssEtsYhctML.aHhVRFA+INQIINcDLlSAFShPD-pFshhhssh.pssattssPlVLDlSahSIWFAFphRF.PssRs-hl..tPLlESVYAScLSlhKlcsppLphhhspsP-shlpA+PochWKAVhcp.PEPl+slhsLstp+sFlshRDlhpWlppsthQcSLhhhh-cEAWtsssD.pDLMhsccVYhHRp.lPEPhLDDlcpFRR-uFYYTNMlDu.PshscsVhhohthhhlpAshGph+uAlRphlDDssal+hGssLRslhlcFF-ShPPp-lLpALPFsYpscE+sG.lshsol+hsspspsaaLlYNV-hsshPDphlslsPshshTKlalpp+lVcRVcsssALuVhN+cFluY+uKhRlMDlTpuLcsGsQLAuPos	....................................................................................................................................................................................................................................................................................................................PRstlsNlhhshuhs.Phs.ah.sss+Istlolstcls..psssFu.l.u.hsTt.QhsDVRKIYLALMFPGQIILDLKIDPGERMDPAVRMVAGVVGHLhFTAGsRFTNlTQNMARQLDIALsDaLLYMYNTRlQVpYGPTGEPLDFpI..GRsQYDCNsFRusFtTGsGYNGWuhlDVEhR-PAPYsHsQRaIRYCsIDSRElIpPtT.a.GhsMpYhhapcMh....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+3589	PF05059	Orbi_VP4		Orbivirus VP4 core protein	Moxon SJ	anon	Pfam-B_5992 (release 7.7)	Family	Orbiviruses are double stranded RNA retroviruses of which the bluetongue virus is a member. The core of bluetongue virus (BTV) is a multienzyme complex composed of two major proteins (VP7 and VP3) and three minor proteins (VP1, VP4 and VP6) in addition to the viral genome. VP4 has been shown to perform all RNA capping activities and has both methyltransferase type 1 and type 2 activities associated with it [1].	25.00	25.00	98.50	98.30	16.00	15.70	hmmbuild  -o /dev/null HMM SEED	644	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-13.16	0.70	-6.76	6	86	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	47	5	0	97	0	564.20	62	99.40	CHANGED	M-P.HAVLYlopsls.hLccuFLPIhcLsGtEsLNsLWhtpGpasTDhYshGslpKWoIRQLRGauFIFlup+.cpIphtDsshshDllI.Ppphscsps.KcFEThIGhcRVtLRKsFGDhLRsYAhpashpFHGSEAETL.hA-P+RH+VhGhPpsPPshsh.sph.ssapsDpPTDEKLVSMLDYllYSAD.plaYVGCGDLRTLppFt+RDp+RFsRVpWhCIDP.IuPEosssNVllhpthlssscDL+pahp.ssslE+lLIWDVpoDputhushEWEppphpEDcLGEpIAhuhpshhuhAlIKHRIPp.ocppapsaoShLlPQPGAPhsMYELRNlhRL-GaS+VDRoHIPcApspplptcDsRpLVcpaHGpsRG+pLK+slaEaLHIpRpsGLpHtu-.PRADLFYLTNppNts+hp-ItcVlEpSsIuTlWVGsc.hasYDDFsYsRpplML+Fsp+s+hVlDGNGhILaLMW+hs.schspclsYDPuWApsFuVlhh+shsss.VPDlSLCRFIGLRphSohLRlpocpVHchsDlLK+LGLDlSGHLFIuLhSuuYlhDLhWWhcMIh-WSlhs+ppKLtslpctpAEVIEW+E-+AsEPWHhhsDLhAALhthuch.ch.hhcp..uslppWl-hLR	..MP.EP.HAVlYVTpELsHllKpuaLPlWclpGsEoLN-LWLpNGKYuoDlYAaGclppWohRQLRGHGFIFlST+.KslQLsDllhsVDVRI.P+-lh+s.D...hKtFEs.IGRRRl+hRKsFGDhLRsYAa+hAI.hHGSEAETLNsANPRLH+lYGhPc.PPhYhEhtph..ts.FsDEPTDEKLVSMLDYhlYSsE.EVHYVGsGDhRTLhpFtKRSPtRF+RlhWHlYDP.IA.s.-sp..sNVhVHphhVsuK+Dlh+phNhLKRVERLhIWDVSoDRupMsDcEWEppRFAEDRLGEEIAhphuGhFS.AlIKHRIPp..h-pYHshSTYLhPQPGAssDMYELRN.hM+L+GYSHVDRphHP-ApVhplVs+DlR+hVEhYHG+D+GRhLKKpLFEaLHIhRcNGLhcEs-EPRADLFYLTN+CNhuh..slYcVh+KShIAThWVGps.LaDYDDaulPRuhlMLpsSa+DlRlLDGNGAILFLMW+YP.-hhKKsLsYDPuWAMNFAVohKEPlP-PPVPDISLCRFIGLRVESSlLRlpNPplHpssDELKRMGLDlSGHLYVTLMSGuYVTDLhWWF+MIL-WSups+EpKLcsL+cStAEVIEWK-pMAERPWHVRNDLIAALREaKh..KhthRps..Asl-SWL-lLR................	0	0	0	0
+3590	PF00901	Orbi_VP5		Orbivirus outer capsid protein VP5	Finn RD, Bateman A	anon	Pfam-B_1525 (release 2.1)	Family	cryoelectron microscopy indicates that VP5 is a trimer implying that there are 360 copies of VP5 per virion [1]. 	23.60	23.60	24.20	143.70	22.00	23.40	hmmbuild  -o /dev/null HMM SEED	508	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.52	0.70	-6.30	14	206	2009-09-11 01:23:19	2003-04-07 12:59:11	12	1	72	0	0	195	0	462.80	62	96.62	CHANGED	tLuRhG+phssALTSsTAK+IYpTIG+AApRhAESEIGSAAIDGllQGolcShlTGEsaGESlKQAVILNVlGss-shPDPLSPGEptltpKlcELEcEp+p-hlpp+HsccIhcKaGp-.L-clh+hhsspt+hpptEccQh-hLcKAlcuhtclhcpEscplpcLtcALp+EsptRTc-EscMlppaRpKhcALpsAI-lEppuhpEEAIQEhhshoADllEsAAEEVPlhGuGhAoulATuRAIEGuYKLKclIstLoGIDLoHLcsPcIpPphlpslLcpsst...lsDppLspultuKlctlcE.ppElcHlpppIlPclKKthc--cc....hts.pcphIHs+sh.paKlPppQpPpIHIYoAPWDSDpVFlFHsluPHHtscSFhlGFDLEl-aVaaEDlotchHtL.GuAppssGRoF+pAY+EFhphAhp.stssthHp+RLpRSpusHPIYLGShpYplSYtpL+pNA.plVpss-LQhHlLRGPl+FQRRsIluALhaGVcll	...oLSRFGKKVGsALTSNTAKKIYsTIGKAAERFAESEIGSAAIDGLlQGSVcSIlTGESYGESVKQAVLLNVLGuG--lPDPLSPGE+GhQhKl+ELE-EQ+sElVRlKaNccI..tc+FG...c-.LE-VYcFMsGps+pEttc-cQaclLpKAVsSYpKlltpEcpph+pLApALQ+Ehs-RTcsEppMVcEYRpKIDAL+sAIElER-GMQEEAIQEIAGMoADVLEAASEEVPLlGAGMATAlATuRAIEGAYKLKKVINALSGIDLSHLRTPKIEPshluThL-pcttc..IPDppLAhulluKtcuIp-NppEltHIcpEILP+hKKhM-E-+E....lpuh--KhIHP+lhM+FKIP+sQQPQIHIYoAPWDSDDVFhFHClS.HHtNESFFlGFDLuIDlVHaEDLosHWHAL.GuAQpAtGRThpEAY+EFhNLAlusshsothHtRRhlRS+ssHPIYLGShHY-IoappL+sNAp+lVYD-ELQMHlLRGPLHFQRRAILGALKaGsKl...........	1	0	0	0
+3591	PF01516	Orbi_VP6		Orbivirus helicase VP6	Bateman A	anon	Pfam-B_765 (release 4.0)	Family	The VP6 protein a minor protein in the core of the virion is probably the viral helicase [1].	20.00	20.00	20.00	22.00	19.10	19.90	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.03	0.70	-5.37	3	135	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	47	0	0	149	0	255.80	52	93.72	CHANGED	LLAPGDVIKRSSEELKQRQIQINLVDWhEScuuKE-..EPK-EucuEpp..lSDGEGsQpccGpKEESuKETcDAsVDRRlHTsVGSGSusKGSGERAsKcADtGDGKstGGGGDADcGuGATGTs.GGGWVVLT-EIARAIESKYGTKIDVYRDEuuAQIIElERSLQKELGISREGVAEQTE+LRDLRRKERs-s+IKAV.+GsRKp.Rpptcusup+EGVtEE.spEEso+IGITIEGVMSQKKLLSMIGGVERKsAPIGARESAVMLVSNsIKDVsRATAYFTuPTGDPsWKEVAREAuKKKNILAYoSTGG.DsKTEFLHLIDHL	................................LLAPGDVIpRSoEELKQRQIQIpLlDW.-s-s.t........Kcp....EsKt.E.scsctp........cDG.E.........G..s.p....p...c.supKcc....uu.....cE...s..pD..AssD..RRlcTsVGpGous+GsG.ERs....sc..ssD..t..............GDuKst....tGuG-s...ctGsGs....s........Gss..t.GtWVVLT-EIAcAIco+YGsclc......VY+s-..s....s....u..pIIplE+SLQKELGloREssAEQTEtLRcL+...R..Kc+st....s+s+...us.....t.....+...GtcK...p....tp.p...cu........s.u.p+.Eu...sp.c-.....s.........pcpss.....pl..u............ls....IEsVMSQKKLLSMIGG.sER+htsIsARESuVMLVSNsIcDVsRATAYFTAPTGDspWKEVARcAoKKcNIhAY.oS....oGG..D..sKpEFLHLIDHL........................	1	0	0	0
+3592	PF00897	Orbi_VP7		Orbivirus inner capsid protein VP7	Finn RD, Bateman A	anon	Pfam-B_1523 (release 2.1)	Family	In BTV, 260 trimers of VP7 are found in the core. The major proteins of the core are VP7 and VP3. VP7 forms an outer layer around VP3 [1].	25.00	25.00	48.60	43.30	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-11.96	0.70	-5.51	7	191	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	65	22	0	159	0	303.00	60	99.57	CHANGED	MDuIsARALoVlcuhso.pDsRsph-sss.-hhuIhlsRaNuhT.RsVohRPooptcRsphFahslDhsluAhslplu.l.PsYp.shtTlulLApsEIPYTspAhsclsRlouphsshtssRp.hh.a.ssptlhtPGpha.hsAups.pshsluushhplolssutpsplsshlhPspsDslMhhFlWpplppapsssGss.-susssplolsssphcAGs.lls..sG.AslslsssuspsuhlchpVhaYhshs.o.shYsshpsplhssYSY+s.pWauLRuhlLpphslPshhPPhhPss-tpplLsLhLlSpLtDsYsshpP.aslhus.sh.sphptul...shsAh+	........................................................MDsIAARALoVh+ACsTLp-sRlslEusVhElLGIAINRYNGLTLRuVTMRPTS.sQRNEMFFMCLDMhLuAsslNlGsISPDYtQphATIGVLATPEIPaTsEAANEIARlTGETuTWGPuRQPaGaFLpstElhQsGRaa.hRAuQslTuslsusshhQVShNAGARGDlQt.lFQspNDPh.MIYhVWRRIcsFu.spGNSQpT.sGVTVsVG.GVsMRAGc.IlA.WDG.QAslpVpNPstpsuMlQIpVlaYlShDKTLsQYPuLsApIFNVYSa+s.TWHGLRsAILNRTTLPNhlPPIFPPsDR-slLsll.LLSsLADVYoVLcP-FslaGVsshsGslsRAl...stsAY......................	0	0	0	0
+3593	PF02072	Orexin		Prepro-orexin	Mian N, Bateman A	anon	IPR001704	Family	\N	22.60	22.60	22.80	25.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.90	0.71	-4.34	3	54	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	40	4	25	44	0	111.00	55	75.78	CHANGED	MNsPsAKVsWAAVTLLLLLLL.PPAlLSLGuuAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQASGNHAAGILThG+Rt.ERPuTRhpsuhpChAustsoVoPsG+uuh	.....................htslhLLLLLLL..shLho.ussAQsLP-CC.RQKTCSCRLY-LL.....H..G..........A.....G...............NH..........AAGILTLGKR+sGs..s.sLQuRLQRLLpu.SGNaAAGILTMG+Rs.t-su.................................................	0	3	5	9
+3594	PF03827	Orexin_rec2		Orexin receptor type 2	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	28.20	27.00	21.90	18.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-8.88	0.72	-3.92	3	46	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	37	0	28	36	0	57.30	70	13.61	CHANGED	LGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNVSKLSEQVVLTSISTLPAANGAGPLQNW	.........LGVH++Q-DRLsRGRTSTESRKSLTTQISNFDNlSKLSEpVVLTSISTLPAANGuGsLpsW.......	0	1	4	12
+3595	PF02999	Borrelia_orfD	Mlp; Orf-D; 	Borrelia orf-D family	Bateman A	anon	Pfam-B_1511 (release 6.4)	Family	Borrelia burgdorferi supercoiled plasmids encode multicopy tandem open reading frames called Orf-A, Orf-B, Orf-C and Orf-D. This family corresponds to Orf-D. The putative product of this gene has no known function.	21.70	21.70	21.90	24.00	21.50	21.60	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.29	0.72	-3.86	4	180	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	29	0	13	111	3	94.80	63	78.45	CHANGED	SLP-cPshPhhpTLpsLup.EApLu-YVMYL.sFLs+TKsKVN....DspYPca.Y.D.SThKDEpoIps...lKaNIslahcYIcKTKPIsctVYpKYS+Lph	......sLPEEPcPPIIpTLKSLAKYEsQLS-YVMYLlTFLuKTKVKVN....DPNYPEYsYPDLSTLKDEHSITu...lK+NIslYLEYIcKTKPIAcKVYpKYSpLKh...	0	8	8	8
+3596	PF04160	Borrelia_orfX	Orf-X; 	Orf-X protein	Bateman A	anon	Pfam-B_3014 (release 7.3)	Family	This short protein has no known function and is found in Jaagsiekte sheep retrovirus. Jaagsiekte sheep retrovirus (JSRV) is the etiological agent of a contagious lung tumour of sheep known as sheep pulmonary adenomatosis. JSRV exhibits a simple genetic organisation, characteristic of the type D and type B retroviruses, with the canonical retroviral sequences gag, pro, pol and env encoding the structural proteins of the virion. An additional open reading frame (orf-x), of approximately 500 bp overlapping pol [1].	25.00	25.00	96.40	96.30	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.04	0.71	-4.41	16	37	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	3	0	0	36	0	151.00	93	93.07	CHANGED	MQPtNPMIYITKIVILYACNLKF.VKLHGKLLNLsLLVLNSLFSLNMVSTLEVYALITSGKQMLLTFLNLDVLNMFMFLLTLFPIFSWP.FTLENQHVTVFNIhCFsFLLQEShKPL+QIMDLsILAVLFNVFVFL.KFIIKQtFLIIHRDKVL	MQPENPMIYITKIVILYACNLKFPVKLHGKLLNLALLVLNSLFSLNMVSTLEVYALITSGKQMLLTFLNLGVLNMFM.LLTLFPIFSWPPFTLENQHVTVFNICCFAFLLQESHKPLKQIMDLVILAVLFNVFVFLSKFIIKQEFLIIHRDKVL	0	0	0	0
+3597	PF04061	ORMDL		ORMDL family 	Wood V, Finn RD, Bateman A	anon	Pfam-B_4871 (release 7.3);	Family	Evidence form [1] suggests that ORMDLs are involved in protein folding in the ER.  Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).	21.30	21.30	45.20	44.90	20.90	20.80	hmmbuild  --amino -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.00	0.71	-4.61	37	393	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	252	0	253	347	2	131.30	48	74.56	CHANGED	NhNssWlst+.........GsWlhalllIhll+lhh.hlP..shosshuWTLTNlsaslsoalhFHhlKGoPF-h...stGsYcpLThWEQID...................pGsQaTss+KFLhsVPIlLFLlooaY...o+Yc.hhFhlNh.sslhlsllPKLPhhH+lR	......................N.NspWhsu+..GhWhhallllhhL+llh.slP..hhSsshuWTLTNlha.hu...............pYlhhHhVKGTPF-t...spGthctLThWEQlD...................pGsQa.T.......soRKFLhllPIlLaLluoaY...T+.YD..h..s..hFhlNh.lullsVllPKLP.hHtlR................	0	63	115	181
+3598	PF02784	Orn_Arg_deC_N		Pyridoxal-dependent decarboxylase, pyridoxal binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.64	0.70	-5.20	17	10956	2012-10-03 05:58:16	2003-04-07 12:59:11	11	31	6377	85	2329	7307	4527	211.00	26	55.03	CHANGED	Dlu...lp+ttthhpthhsh......hpshYAVKsssshsllplLschG..s....GhDsuSpsElphVLu....hGsssc+IlassssKstuplchAhpp....tlshhshDshpELcpltchtsct....plhlRlpss.-spspshlus.....KFGhshpp...stthlctApphs.lplhGlphHlGSths-hpsahpAspcshplhctht.phGh...hchLDlGGGasss.p...........s.phpchupslpsulcchhs.......ptspllsEPGRhhsus	.............................................................................................................................h.....t.t....................ha..sh.Kss.p....t.l...lp.hh......h.....p.........G..................................sh-.ssSh.............sEl.h.s.ht..............hs..h...........s.......p....p......l.hhss.s....h....K......s.tt.l.p...h....A.h.t...................th.h.h.h.sh-.s..t-...l....p....h.lt...p.hs..th.................................tl.hlR.lp...........s......................t..t..t...s....t................h......h...s...s.......s.......t.....s.....KF.Gh.sh......p.............p..........h........h.t.h.l.c..t..s.p.p.......h.............s..l..p..l.h.Glc..hH..l...G..S....p.h..s.....c..h..c..s....ah.pu.....h.....p...c....s....h.......plh.sph..t......ph.............G...h.....p.................lphlslGGGhu.l...s.Yt.........................................t..t.........t...h....h...t........h.......t...h...h...pt...h.h.t...................plh..hEsGRhlsu............................................................................................................	0	749	1458	1952
+3599	PF00278	Orn_DAP_Arg_deC		Pyridoxal-dependent decarboxylase, C-terminal sheet domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	These pyridoxal-dependent decarboxylases act on ornithine, lysine,  arginine and related substrates.  	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.45	0.71	-4.37	105	9303	2009-01-15 18:05:59	2003-04-07 12:59:11	17	26	4591	89	2414	7018	3338	153.60	20	33.75	CHANGED	sLlspVhsh+p.st..........................................................................................tt.............hhh.lssGhhsp.hsshhhst....hhslhhht...............................................hpspstttsslsGsoC-usD.hl...sp.........chhLP.........plp.GDhlshhssGAYshshus.saNuhs..tsshlhl	..................................................................................................................................................................................................................hsplh.hcp..................................................................................................................p...................hhh.lDsuh.ts..t....hcsh.h....h.s.t........ha....l.h..s..lpt..................................................................hs.p..t..s....t..p...p..ssl.sG...hC-.osDhl..sp.............................................shtLP........................php.G.D.hL..s.hhssG..............AYsh.sh.us....saNshs..pss.h.........................................	1	788	1532	2038
+3600	PF02088	Ornatin		Ornatin	Mian N, Bateman A	anon	IPR002463	Family	\N	25.00	25.00	40.40	40.20	18.40	17.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.35	0.72	-4.39	2	7	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	1	0	0	6	0	37.90	75	84.39	CHANGED	l..Ct-h+E.GQPscKCRCsGKPCTVG+CshARGDssDKCh	L.YCG-FRELGQPDKKCRCsGKPCTVG+CphARGDssDKCh	0	0	0	0
+3601	PF02250	Orthopox_35kD		35kD major secreted virus protein 	Bateman A, Mian N	anon	Pfam-B_3549 (release 5.2)	Domain	This family of orthopoxvirus secreted proteins (also known as T1 and  A41) interact with members of both the CC and CXC superfamilies of  chemokines. It has been suggested that these secreted proteins  modulate leukocyte influx into virus-infected tissues [1].	21.90	21.90	23.60	22.30	21.50	21.70	hmmbuild  --amino -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.46	0.70	-5.05	5	131	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	30	7	0	113	0	211.00	44	89.18	CHANGED	hCopcEDs+YMGIDllhKV.TKpspTsssDshCQulp-lpESsc-tDEuoEctuTSTspGDshu...................oTYaTlVGGGLSlsFGFTGCPplsSlSEascGsaVYVRLSScAPW.+sTsslShNRsEAL.ulLEKCELSIsIKCSNpchsE.........TThsouoLsPcIopcsT-p...............uDIIGSTLVDT+CVcSLDloVcLGDMC...K+oS-LSlKDuhKYsDGELl....-DsuDsaslsSssLpAC	....................................................Cptctpphahthpl.h+l.s+ps.h.sssphC..hhphpps.....................-............t..s.ps-s.......................sshhSl.sGGLphshuahpC....+olup.sstsTV.A+huSlsPh..pscsss.uhT..+.....--s....l....thlc-C.VsIpl+Cs.-cpcs...............hhppssht.p.scpKs.s......................pcllGSh..I..VDscCVpslchpV+ItDhC...KppS.hpl+DhFphssGp...........................................	0	0	0	0
+3602	PF00213	OSCP		ATP synthase delta (OSCP) subunit	Finn RD	anon	Prosite	Family	The ATP D subunit from E. coli  is the same as the OSCP subunit which is this family. The ATP D subunit from metazoa are found in family Pfam:PF00401.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.82	0.71	-4.40	192	4976	2012-10-02 21:03:42	2003-04-07 12:59:11	13	14	4570	6	1207	3297	2540	165.70	25	84.70	CHANGED	lAppYAcALaclA.p.-.......ps..t.....l-ph...tppLptl..ssltpsscltphlssPtlsspp....Ktpllpp.lhps........................tl..sp.....hstNFlplLs-ppRlshLspIhptapp.lhsctcshhpspVpoAhsLsspptpplpptL...ppthsp.plplphplDssllGGlllcl...GspllDuSlpscLpplpppL	.............................................................................................................................................lup.YApAlaphA..h.c.........ps...p.......l-ph...tp...pLthl....thl..t..p...s..t.....p.l.tphLs.s....s....s..lsspp....+tc.hltt...lhsp..........................................th...st.....h.pN.h.l.p..lls.......-s.pRl.s...h.ls.p.l.........hppa.p.l...hs.p.p.p...sp......h....ps....pVt.S......A......hs..L.o.....c.....p.....p.hp.cl.tpt..l.............pc..p....h....u.....p.....p...l.p.l.p..splD..sl.lGGlllcs..........G...c.....p.....llDsSl+s+Lpplppt...................................	0	405	776	1019
+3603	PF02566	OsmC		OsmC-like protein	Mian N, Bateman A, Finn RD	anon	Pfam-B_2694 (release 7.0)	Family	Osmotically inducible protein C (OsmC) (Swiss:P23929) is a stress -induced protein found in E. Coli. This family also contains a organic hydroperoxide detoxification protein (Swiss:O68390) that  has a novel pattern of oxidative stress regulation [1].	22.80	22.80	23.10	23.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.55	0.72	-3.82	173	7485	2009-01-15 18:05:59	2003-04-07 12:59:11	14	22	3139	56	2170	5359	1255	100.10	21	63.21	CHANGED	ussp.....ussPh-llhuuluuChshshthhsppp.th..pl..psl....plplp.......h...chs.t.................hpplp.....lplplthss......s.......pphpchlpts.pchCslt.psl.ptssplphp	.........................................................s.tsp...ussPt-LlhuuhuuChshsl...thhhpct..th...sh.....ssh............plpsp............s............pts.ps..s.t.................hpplp......lphpl..p..hs..s.........hs.t........pph.pcll..........p....hu...c....phCslu.psl..psslslph.p..............................	0	654	1315	1789
+3604	PF03207	OspD		Borrelia outer surface protein D (OspD)	Mifsud W	anon	Pfam-B_2915 (release 6.5)	Family	\N	25.00	25.00	66.10	66.00	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.91	0.70	-5.23	2	24	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	13	0	1	22	0	218.40	86	98.61	CHANGED	MKKLIKILL.SLFLLLSISCs...........L.......DNEGsNS.sYESKKQSILuELNQLLtQTTNSLKEAKNTTDNLNASNEtNKVVEAVIssVNLISSAADQVKuAppNMHDLAQMAEIDLEKIKpSSDKsIhAuNlAKEAYsLTKAsEQNMQKLYKEQpc..co.S-SD.........hpsSsEIKQAKEAVEIAWKATVcAKDcLIDVENsVKEsLDKIKTETsNNTKLsDIcEsAELVLQIAKNstEIsQEVVAh	MKKLIKILL.SLFLLLSISCs..................LDNEGsNS.sYESKKQSILuELNQLLtQTTNSLKEAKNTTDNLNASNEANKVVEAVIsAVNLISSAADQVKuATKNMHDLAQMAEIDLEKIKpSSDKAIhAuNVAKEAYsLTKAAEQNMQKLYKEQpc..co.S-SD..........psSsEIKQAKEAVEIAWKATVcAKDcLIDVENsVKEsLDKIKTETsNNTKLADIcEsAELVLQIAKNsKEIsQEVVAL...	0	1	1	1
+3605	PF02471	OspE	OspEF; 	Borrelia outer surface protein E	Mian N, Bateman A	anon	Pfam-B_962 (release 5.4)	Family	This is a family of outer surface proteins (Osp) from the Borrelia spirochete [1]. The family includes OspE, and OspEF-related proteins (Erp) [2]. These proteins are coded for on different circular plasmids in the Borrelia genome.	25.00	25.00	30.80	30.40	21.50	20.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.42	0.72	-4.17	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	28	0	4	77	0	108.10	74	60.70	CHANGED	FSEFTVKIKN.KDNsuNWoDLGTLVVRKEEDGI-TGLNsG.......hGHoATFFSlEESEVNNFVKAMTcGGSFKTSLYYGYK-EQSss.NGIpNKEIhTKIEsINsSEaITFhGD	FS-FTVKIKN...KD.NuuNWsDLGsLVVRKEEDG...I-TGLNsG........GHSATFFSLEESEVNNFlKAMTcGGSFKTSLYYGY+-...EQSst.NGIpNKEIITKIEpINsoEaITFLGD...	0	4	4	4
+3606	PF03968	OstA		OstA-like protein	Bateman A	anon	COG1934	Family	This family of proteins are mostly uncharacterised. However the family does include E. coli OstA Swiss:P31554 that has been characterised as an organic solvent tolerance protein [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  --amino -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.59	0.71	-4.13	50	3517	2012-10-01 21:43:16	2003-04-07 12:59:11	9	18	2150	10	780	2490	1095	121.40	23	30.26	CHANGED	pIcuDpt.phcp..pss...hshasGNVhlpQGshplpA-clhlhpstp............................tthpplpupG.....shhptphphsspthpupAcphpYp..stpchhhLps.sAhlp......psssslpGspIphshppph	..............................................................................................IpuD.ph.p.h..c......tss......ssaoGN...V.h..l..p..Q......G..s..h.p.l.p...ADclh..lppsps.........................................................................................................................pshp.plssts........shht..t.p.h...p....h....s.....s....c........h..c.G..pAsphp.Yc.....htp.chhhL...p...s....s....u.hlp..........................psspsl..p..G.sc.Ihaphcpt.........................................................................................................	0	220	460	635
+3607	PF04453	OstA_C		Organic solvent tolerance protein	Waterfield DI, Finn RD	anon	COG1452	Family	Family involved in organic solvent tolerance in bacteria. The region contains several highly conserved, potentially catalytic, residues [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.29	0.70	-5.38	45	2046	2012-10-03 17:14:37	2003-04-07 12:59:11	9	9	1874	0	426	1515	1009	363.00	25	49.70	CHANGED	ppRhh.hthpppttlss.sap........htl-hshlSDp.sYhpDhsss.............hshtspsp.L.p..............puphsY......ttt.h.hshp..sppapsl.............tttpsspP....aptlPplshshhtsphh.....shphshpuphspFpcpstth.................................pusRhphpPplshshppshGh.lssphplp..tsh..................Yphststs..t............shspshsRslPphsl-sshshtRshph..................tappoLEPchtYhh.....hP..p..........sQssl..P..........saDos.hphshtpLFpps+asGh.DRIssuNplohulosph...hcsssh........................phphslGQhaahpsppshh.................sp....ss.ppstSshhsphshphspthphsushpas.pspphppsssshpYps...p...sthlslsYpahpsphttt...........................hpplshsstaslsp............pW	.......................................................................................................................pRhh.hhhpcst.shsp..sap.........hslDh.spV..S..D......sYhpDhssp........................hsssossh..hpp...........................phplsY..............ts..psh.s.hslp.........sppaQsh......................ptps..sps..........YpthPpl..shsh..htsshh...............shchph.uph.spFh..ps..p..t..s.s...........................................pusRhphpPslshPhs...sshG...lss.ph..p..lh........sst...........................Y.ptsp..s......t.............................phpcs.ssRshP.p.h.pl-s..ths....a.....-Rsh..ph....................sa...p...QTLEP+hpYlY.............sP..h+................sQs.sl...................saDos.....hp..............s.hssL.F....p...sp.pasGh..DRlssuNplohGloo.Rh....h-sss..........................................E+hshslGQ..haYhscppst.......................................................p.......sspps.s.pss.hs.s.phthph..........spphshpushp.....Y....cs.c...s....p..hspus.sshpYp......s.......pphlplsYpYtssp....hh..t.tt.......................................lpQlshsuta.lsspW..........................................................................................................................................	0	113	246	338
+3608	PF00865	Osteopontin		Osteopontin	Bateman A	anon	Pfam-B_1593 (release 2.1)	Family	\N	25.00	25.00	28.50	28.50	24.40	24.30	hmmbuild  --amino -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.47	0.70	-5.17	7	105	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	40	2	25	108	0	216.10	52	93.19	CHANGED	K.AsSGSSEEK.......h.pKasDAVAThLpPDPSQKQshLAP..QNshSSEEsDDh.KQpTLPSpSNESp-phDD.DDDDDD.DHssSpD...Ss-S--sDpsDD.cpsDESHHSDESDE.VssaPT-.stspVhTPslPTs-ssD.GRGDSVAYGL.RSKS+pF+hSchQhP..DAT-EDlTSHhcScEhsss.KsI.VA.cLphPSD.DSptKsSpEoSQlD-pSVETcS+EQS+pac.+AsDpSs..................E+SssIDSQEs..SKsSpE.p...F+SHEDKLs.D.KS.E-D+HLKhRlSHEL-SuSSElN	............spSGSSEEK.......h.shass.luoWLpsDPSQKQshLAs...QNslSSEE.psD..cQpTLPSpSN.ESH.-chDD.DD-DDs......SpD...Ss.-.............sD-S+cSDESDEhVs.cFPT-.ststsFTPhlPThss.s.GRGDSlsYGL.RSKS+.phchs..s.Qhs..DuT-EDhTSchcS.tE.pts.csh.hsp.l.hsSs.cspt...ps...........S.....EsSQhD-.ShETpSpcps+.hp..c.spccSs....cpSs.I-SQEp..S+sSpE............hpStEc..s.D.+S.E--+aLKh+hSHEh-SuSSEhN.......	0	2	2	5
+3609	PF00185	OTCace		Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	29.40	29.40	29.70	29.70	28.10	29.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.01	0.71	-4.36	123	10559	2009-09-13 17:21:38	2003-04-07 12:59:11	19	39	4814	296	2543	7158	4618	158.00	28	43.70	CHANGED	cGl.clshlG......D.t.splspShl...hshst.hGh.c.lplsuPps..h.s.......t...h...........t..t.hplp...p..shp.culps......sDllasspht........................pEc.............tphcthps.aplspchlp..t.sps.c...sllhHsLPh.......R.....s.........................EloscVh-.....s.sp.ShlacQAcNtlasphAllhhl	....................................slpluhlG........D..thspsupShh...........hshsp..h....G...h.....s...lpls.uPcs...h.s..............................t..thl................t...ht..pt..G.......spl.pls.......p.shc..-u.l.c.s......s.Dl...lhss.pht........................cEpt...........................pc.hpt.hps....at...lspc..h.hp....t..sp....s....s................s.lhhHsLPs............R....s.........................h.E.l.os-Vh-..........u.sp.ShlFc.QAcNtlasptAllhh....................................	0	832	1612	2137
+3610	PF02729	OTCace_N		Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.90	20.90	21.20	21.40	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.81	0.71	-4.53	105	10527	2009-01-15 18:05:59	2003-04-07 12:59:11	16	43	4811	296	2554	7124	4842	142.50	36	39.25	CHANGED	+c.llsl.pD...hspc-lppllchAtph+c........thtpt................thLpG.+sluhlFhcsSTRTRhSF.EsAhppLG..upslhls...ssspl..........u+.........GEolpDTu+sluph.sD..slllR..........phppsslpph..Achs.....slPV...INuhs...stpHPsQuLsDlhTl...pcc	.............................................................+chLslpD.hotpEl.ptllchAtphKp......................ttppt............................hLcG..Ksluh.lF.c.sS..TRTRsSF.E.sAhtcLG..ucshhls....sssopl................................u+...GEoltDTu+...lLuph..sD....sIhhR................p.p.p.t.t.s...cpl.....Ac..au..............slP.V.....lNuhs....s......ptHPTQsLhDlhTlpE.........................	0	833	1616	2149
+3611	PF02338	OTU		OTU-like cysteine protease	Mian N, Bateman A, Finn RD	anon	medline:20130692	Family	This family is comprised of a group of predicted cysteine proteases, homologous to the Ovarian Tumour (OTU) gene in Drosophila. Members include proteins from eukaryotes, viruses and pathogenic bacterium. The conserved cysteine and histidine, and possibly the aspartate, represent the catalytic residues in this putative group of proteases.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-11.08	0.71	-3.52	51	2248	2012-10-10 12:56:15	2003-04-07 12:59:11	14	84	441	33	1395	2228	90	124.90	19	19.92	CHANGED	.uDGs.Cha+uluptlh..................plRpts.....sphht......................ppppthpphltsp.................hh..h.t.t....sWus.......................................plpl.tuhuphh..phpIhl..............h.tsht.....hh.p.h.....tthpptlplha.t.....stHa	..........................................................................................uDG.sCLa+.Alup...tlh.............................tptth.hp...plRpts............sphlp..............................................................pptppa.p...hlpss................................................ahpphtpss.....pW.Gs................................................................................................pl-..l...huluchh.....phsIhl.....................................hp....ttst.......h....t.......................t..........hhh.............t..Ha........................................................................	0	507	785	1100
+3612	PF00724	Oxidored_FMN	oxidored_FMN; 	NADH:flavin oxidoreductase / NADH oxidase family	Bateman A	anon	Pfam-B_642 (release 2.1)	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.92	0.70	-5.45	12	10595	2012-10-03 05:58:16	2003-04-07 12:59:11	15	107	3470	129	3408	9713	2738	312.00	28	71.36	CHANGED	pLFpPlclGs.hpLppRllhsPh.ophtutccG.lsp..hhhcYastRuphssshlIsEushlsspus.shssssslas-cpltpa+cls-AlHcpGuhlhlQlaahGtps..schhtpts.........sstss..hsss...............+tlot--Icphlp.paspAA++Ahp.AGhDuVElHuApGYLls.pFLsPtpNcRoDcYG.GShENRsRFsLEll-tlpcslGp-t.....luhRlSs.shhtst.tshtEs...h.hhhhhschthchhsh.phAhl.chspPt.htshpspht...p.tss...phl+phhphPllssGp..hsssp.tshl.htc..scsslluhGR.hlusP-Lsp+lccGh..p	.........................................................................................................LFpPhp..l....s........s....h.....pL.pN.R..llhuPh....s.........p.............h.......t..........u.........t...........t......s......s..................h...........s.........s......h.....hhta....Y..t..p.R....A..p..........s.s.GLl.......l..s.....t.u.s.t.l.s......s.......p.........u.......t.......s............h.....s.......t.........s....s.....s....l........h........s......s........p.......p........l..........t.....u....h.+...p...l....s.....c.....u............l..........H.............t...............p.........G.............u.........p..............h.........h....lQ.l......h.H...s.G..Rh..ut...........t...h....stt............................uss...............s..ht.t..................................s...........+th.o.p.c.-I......t...p...l..l.p.sFspAAppAh................c.A.G..............FD..............GVE.lHu..Ac.GY..L.lp...QFlos.hoN...p.Rs.D.p......Y.G....G...S.h.-N.....R..h....RhslEllc....A....l....p....p...s....h....u....s....c..h..........lshRl.....S...s..............h....c....h..............h..............p.......s.........s.......h......s.......h..p....-s...................ht.h.h..p...h.......h....t...t....h....t......h......p......h...h.....................................t...h.......u.........h..............h.....p..........h.......s...p.....................................t.....s..............s..h....t...........................h.........................t.t.l.....+...p......t......h.....p.....h..s...........l..l....s......s...Gt.....................h............s.....s...........p...........................A.................p................p.h........lt.p.....................G........t......s........D....h.lu..huRshls.sPchst+htps..........................................................................................................	1	954	1981	2860
+3613	PF00174	Oxidored_molyb	oxidored_molyb; 	Oxidoreductase molybdopterin binding domain	Sonnhammer ELL, Bateman A	anon	Prosite 	Domain	This domain is found in a variety of oxidoreductases. This domain binds to a molybdopterin cofactor. Xanthine dehydrogenases, that also bind molybdopterin, have essentially no similarity.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.09	0.71	-4.84	150	4576	2009-01-15 18:05:59	2003-04-07 12:59:11	14	45	2283	46	1578	3981	1512	159.10	27	44.65	CHANGED	hspts.hP............tl.s....tsapLpl.....s..G.......h.Vcpshshohc-Lt.p..hPp..tphss.slpCsss....................Wuh...h..sspWsGV.LpclLctsss...............p......su.........................paVhhpu.hD....................................................s.....YspulPl.scshc......................csllAaphNGc.....sLs.pHGhPlRLllP.shhGh+ss.KWlpcIplhsp..t......tu...aWpp	......................................................................................................psaplpl.........p..G......................V.tp.....s.....h..s.....hshp-Lh...t...h.s......p..p..h..h..h....p.h.p...........Csts...................................Wuh.....ss.WpGssLpclLp.t..s..ts..........................................................p...ssA.....................+aVtFpu.h-...........................................................................s..Y..s.p.u.l.pl..s.cA.hc.........................ts..llAht.h..sG..c.......sL.ss.p...p.G..t..P..lR.lll.........P........t......h.....h..G........h+.s.....s.K..hlhpIplspp...s.......sha............................................	0	442	944	1319
+3614	PF00148	Oxidored_nitro	oxidored_nitro; 	Nitrogenase component 1 type Oxidoreductase	Sonnhammer ELL	anon	Prosite	Domain	\N	28.60	28.60	28.70	28.60	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.07	0.70	-5.83	116	3989	2012-10-03 15:23:08	2003-04-07 12:59:11	14	13	1338	128	1280	3778	993	356.20	21	84.43	CHANGED	CshhGAh.hshhslcsshsllHGstGC...ssastshhspphc.............c.h............hhoTshsEpsslaG.GpcpLtculcplhppapP..chIslhoTChsphIG-Dlpulscph.....ppph......................llsssssua.sssp.pGactuhpullcpl.....................................................................................p.tpcst...............plNll.sshtls.....uDhpplccll.cthGl.........................chsshhsussslc-lpphspAphslshspp.htt....suchlcccaGlPhhp...ssshGlpsTsphlppluchhG................tt..h.sptltc....cc.sphhcthhc.h+....thlt...G.++.........sslhus..s.shshulsphlt.E.hGhcsshssstssstt.h..t........................................................ph.t.htt............lh.s..ch.h-lcph.lpphp..sDll.....lGssp.sphhucch...........h.hGhPhhsthsht.ptshhGYpGsh....plhcclssslh	.........................................................sthhGuh.hshtslcs.shhlhHGs.GC...........st.a.h.h.sh.ht.thht...................p.......................hh.sosh..pEpsl..l..h.G...up...ccL...h....csltphh...p.......h.....h.......t..P...............ph.lhlhsoCsstlIG-Dlpuhs.cph.....ptchsh...................sllssps...s.ua..sssps.tG.hchshp.ulh..chhhs.........................................................................................................................t.t..tp.t....................slsl...l.Gshshs.........u-h..hp...l+...tl..L...cph...Gl..........................................cl.shh.ss.s.s.s.hp-lt.ph......sp.Aphsl.......hhs...............t....ht...............huphhpc..c.h.uh.Phht...............................hG.h..pthtthlptl.sp.hhs.................................................................h....t.....ltt........tp....tt...h.......h...t...t....h.p....hp..........hht.........G..+p................hh.l....hss..s.....h.h....t...........hsphh...-....hGhps.hh.h.sh....h.t..ptt...........t........................................................th.t...htt......................lh.t...s..........p....h..phh....t.p........ht.............s-...lh.............h..us.h..tt..hh.t.ph.....................uh..P.hh...........h.hhGatGh..hhp.h.....h....................................................................................................................................	0	432	869	1085
+3615	PF00361	Oxidored_q1	oxidored_q1; 	NADH-Ubiquinone/plastoquinone (complex I), various chains	Finn RD	anon	Pfam-B_4 (release 1.0)	Family	This family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.78	0.70	-5.13	33	91875	2012-10-02 00:39:38	2003-04-07 12:59:11	15	57	35037	6	4521	86901	9765	225.60	28	56.30	CHANGED	ussllhhaluaE..hhslssal.Llshattp.cuhpAuhphhlhstluShhLLhuhh..hlahhs.uohsa.tlhp...............s....hhhhhhlhluhhhKhuhhPhHhW..........LPcuhtusssssullhuuhhlhsulallhRhh.lh.......hh.hlhhluslohlluuhsulsQsDlK+llAYSoluphGa.hhshluh...s.h..tsuhhhhlsH.uhhpusLFhhs.shhhpp.t.........spslhhhs.ulhthhPhhthhhhlshhuhs..GlPsh....sGFhuKhhlltsh	....................................................................................upphh..h.ahh.hE.....sh......hh.......l....................h.................p............p........................p.........s.........h..............p..........A.....s..........h....p.hh.l.h..p.t.h.u.s...h.h....l..L..h.u...h.....h.........h......h................s......G......p.......h.....p..h..t..p..h.t.....................................................................................h........h...h.....h...h....h...hu.....h..hh...K.u.h..Ph..H.h..W..............hP.c.sh.p..u...........s......s.....h....s....u..h..........l..h...u.s.h.....h...h.s.s.h........h.l...l...h....ph...............h...............................................................h...l....h....h...l.u.lh....o.hh.h.u.u.h..hu..L......s......Q.....s......p.....l..+.....+ll.....A....aS....olu....p.h...G..h.........hh....hh.lhh......................ss.................t.....h..u....h.....h....p.h....h.s.....a....uh.h.p...u.h.l.Fhhh....s......h.p.p.hp................................spsh.h.hh....t......s.........h..h...p...h...h...P....h..h..s...s....h..h........h..l..shL.uls........G..l.P..P.h.............s.s.FhsK.hIlp..t........................................................................	1	1460	2936	3788
+3616	PF00662	Oxidored_q1_N	oxidored_q1_N; 	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	Bateman A	anon	Pfam-B_22 (release 2.1)	Family	This sub-family represents an amino terminal extension of Pfam:PF00361. Only NADH-Ubiquinone chain 5 and eubacterial chain L are in this family. This sub-family is part of complex I which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.03	0.72	-4.41	32	19906	2009-01-15 18:05:59	2003-04-07 12:59:11	15	26	14684	2	1246	18780	2012	60.60	42	9.78	CHANGED	hlphhpWhssps.hplshuFhhD.hohhhlslshhVohhlhhaSh.YMp.pDPphs.......RFFpYLth	..................................hhWsWh.h.s.....ss....F...slp..hu..a...hl..D..s..LoslhhhllohVu......hhVll.YS..ss..YMu...c..D....p...s.h.....................RFFsYhsh...............................	0	404	818	1051
+3617	PF00420	Oxidored_q2	oxidored_q2; 	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	Finn RD	anon	Pfam-B_193 (release 1.0)	Family	\N	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.15	0.72	-4.39	194	10049	2009-01-15 18:05:59	2003-04-07 12:59:11	19	10	7521	2	1437	7095	1962	96.00	27	90.05	CHANGED	hhhhshhhhFhlulhGlhh.RppllpsLlsLEhhhLulhlhhshhuh.h...........................................pshhsphhslhlLshuAsEuulGLALLVthhRsaGo-plpslslLps	................................................h.hhhhhshhFhlGl..hG..l..l.....h...Rp.....pllphLl..sLEhMhhulhlhhs.hhuh.h.........................................................................................................................................................tss..h..s...phhsl.hhl.shuA.sEuulGLAlllth.h..RspGosplpslshhp..............................	0	454	913	1189
+3618	PF00499	Oxidored_q3	oxidored_q3; 	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	Finn RD	anon	Pfam-B_61 (release 1.0)	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.24	0.71	-4.41	100	8649	2009-09-11 06:35:13	2003-04-07 12:59:11	15	6	7126	2	830	7391	1836	152.30	22	84.54	CHANGED	lhsslhhlh..s.psPlhhslhllhhslhhuhh..hhhhs...ssahuhlhhllYlGGlhllFlahssls......ssphhth.......................................................................thhhhhhhh.......hhhhhhhhhhhht.h.hths.ht..th..h...............................................hhssthh.hhh....hhslhLllslls..sltls	........................h..sul.hss.s.......s..ssPlaus.....LhLll.shhsssul..hhh.hG...usFlul.llhl.lYlGuhhVlFlasshhs............spp.hs.ct.h.t.p.h.........................................................................................................................hhhh.h..h.s.hhh.............hhh..h..h..h.....h....h......h....h......h.......h....t.......t.....h.........h....h.....s.....h.....s....s.....h...t...t..h..s..h..t..ht...............................................................................................................................hhth.la.o........h.sh..hhh......lsuh..hLLlsllssl.l.....................................................	0	275	538	685
+3619	PF00507	Oxidored_q4	oxidored_q4; 	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	Finn RD	anon	Pfam-B_68 (release 1.0)	Family	\N	21.60	21.60	22.10	21.60	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.52	0.72	-4.20	99	11473	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	9331	2	859	9513	1923	105.50	45	89.88	CHANGED	llshllhhl..............uhh.......ls......cph..t...-K.osaE.CGFcPh.spuR...hsFol+FaLlullFllFDlElshlhPhshhh.....tt.hhhh..hhhhh...hFlhlLhlG.lhYEWppGsLcW	...................................hh.luhlLhhl........saa..........Ls...p.....h.ss...ss.......EKhSPYE.CGF.D.Ph...Go..AR.............LP.FSlRFFLVA.ILF..LlFD..L.EIALL..LPhs.huh..........h.p.s....s...h.hs..........hhhs.h..hh.l.l.l.L.s.lGLlYEWt.pGuLEW...............................	2	284	563	713
+3620	PF01059	Oxidored_q5_N	oxidored_q5_N;	NADH-ubiquinone oxidoreductase chain 4, amino terminus	Finn RD, Bateman A	anon	Pfam-B_381 (release 3.0)	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.32	0.72	-10.67	0.72	-4.18	143	6646	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	4701	0	249	6505	763	104.90	37	24.78	CHANGED	MLKlllssl.hLlPhshh.t...hha...hhhshllhhlShh.h..hp.shthhhs.hhshh.huhD.lSssLllLShWLhPLMlhASppthpp.shtpp+hFlhhlhhLplhLlhT	.....................................................................MLKlllP.Tl..ML.hP..h.s.ah..s...p...hlW....s..shh.h.SllI.uhhSL....h......a............lp.................s..p................s............h...........t.....s..........hs.h.........h.husDsLS.sPLLlLTsWLLPLMIl.A....SQ.sH...lpp.EshsRp+..halohLlhLQ.hhLIhs....................	0	77	152	195
+3621	PF01058	Oxidored_q6	oxidored_q6; 	NADH ubiquinone oxidoreductase, 20 Kd subunit	Finn RD, Bateman A	anon	Pfam-B_1345 (release 3.0)	Family	\N	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.22	0.71	-4.54	169	7525	2009-01-15 18:05:59	2003-04-07 12:59:11	17	28	3465	80	2007	4724	2053	123.50	33	48.57	CHANGED	CsGC...shul.tshtsshh-lh.t..hp.........htat..slhssst..........................ptDlllV-Gul..ts......................pstlchlhcht.tcschllAlGsCAshG.Gl.shts.......sh...........................................slhp.........lsV...lplPGCPPpPctlhtslhtl	..................................................sC.slph..hssts.s...hhDh............................c.aG.h.hh.h.u.ust...........................................puDlhlVsGslspch.......................................................................................tPs.l.c.+..l.a-p.h.s.-P.+h.V..IuhGu.CAssG.Ghathts........sh............................................................................h..........lpGl-.ch...............lPVD..lalPGC...PPpP-shltulh..h...................................	0	667	1322	1707
+3622	PF01237	Oxysterol_BP		Oxysterol-binding protein 	Finn RD, Bateman A	anon	Prosite	Family	\N	25.40	25.40	25.40	25.50	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.26	0.70	-5.96	149	2468	2009-01-15 18:05:59	2003-04-07 12:59:11	13	56	312	10	1498	2357	5	330.10	27	52.43	CHANGED	ulhuhl+p.....slGpDLS+.lohPlhhsEPhShLQ+hsE..hEY.scLLspA...sp.................psDshpRhhhVss.aslSshssp..hpR.t.......KPFNPlLGETF....E.hsc..t.....shchluEQ.........................VSHHPPloAhascs..p.s...............aphtupstscsKFhGp.Shplp........hGtsh...lplpp........................................................................................t.........sEpYshsp..ssspl+sIlhGphalE.hGchhIpsp.........p..oG.pshlcFps.p.....Ga...huup...pp.........lpGt..lhc..p..............sspsha..plpGpWs.cplhhppsp...........................................................................ttpt.....phlWcssshss..p..pha.h..s.hs.hsL..Nt.....c..........plssTDS..RhRPDp+AhEpGch-tAspEKp+lEccQRptR+cc..............pppsp..pap.P+aF..pcs......................hpshstp................a.hpss......YWch	.......................................................................hhsll+p......plG.h.D.L..o..+...ls...hPs...h.EPhS..hLp+.h.s-.....h.p.a..s...c..L.l.s.p.A...s.p.............................................................p.ps.shcRhh.h........Vsta...hl..Su.atpp.......htpst...............................KPaNPlL...GETa..........................................-.h.p.....p............sh.ph.....l..uE.Q.........................V.SHH.....P.P.........loA..h.a..sps......ps...................hph..s.p...ht...h+.sK..F.........h.........G.p..S..lpl..h................hG..p..hp.......lph.p.....................................................................................................................................t......sEpY.hh.sh..ss..stl+..sI...lhG..p..ha..lEh.hG.ph...pIpsp.............................p.....ou..h..psplpF..pt..p.................................sa....h..u.s..ph.....pp................lpGh...lhs..t....................................stcs.h.h....plt.G.pWs.pp.h.h.httss..................................................................................................................................pt......phlacss....h.s........t..t..ph.h................L............c.........................................ssp-S....hh+...s.s.p........c..t......l.c.p...u.c.h.-t..AsppKp.clE-tQRtt...p+pc.........................................................p.p.p..t............tap.......s+......aF.....ppt.................................................................................t..............................................................................................................................	0	500	792	1157
+3623	PF00543	P-II		Nitrogen regulatory protein P-II	Bateman A	anon	SCOP	Domain	P-II modulates the activity of glutamine synthetase.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.23	0.72	-3.54	93	4823	2012-10-01 21:59:08	2003-04-07 12:59:11	17	7	2688	149	1478	2996	1680	101.60	53	82.59	CHANGED	IpAII+..P.KL--V+cALsphG.ltGhTVo-VpGhG+QKG..sElaRGs....................cahss.hlPKl+l-llV.sDctl-pll-sIhcsApTGc...lGDGKIFVtsl-..cslRI.RTG	....................................IpAIIKPFKL--V+EALscl.G.....lp........G.hT.V.o.E.VK.GFGRQK.G.H...TE.l...Y.RGA.................................EY.hV-..FLPKVK.lEl.........lV.s.D.-...l.-.p.ll-sIh...cs.Ap...T...GK........IGDGKIFVhslp..cl.lRI.RTG.........................	0	486	973	1256
+3624	PF04275	P-mevalo_kinase		Phosphomevalonate kinase 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Phosphomevalonate kinase (EC:2.7.4.2) catalyses the  phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate,  an essential step in isoprenoid biosynthesis via the mevalonate  pathway [1]. This family represents the animal type of the  enzyme. The other is the ERG8 type, found in plants and fungi, and some bacteria (see Pfam:PF00288).	23.90	23.90	24.90	24.20	22.70	23.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.53	0.71	-4.37	11	154	2009-09-10 15:39:43	2003-04-07 12:59:11	9	8	123	1	104	164	4	113.90	38	29.84	CHANGED	hSGKRKSGKDalo-+LppRLsts+sp..IlRISpPlKpcaA+chsLDhpcLLusGsYKEpYR+DMIpWuEpcRpcD.GaFCRtAhpps.......spslhIVSDsRRpoDlcaF+EsYG...hshsl	....................hoGKRKuGKDals-h.ltp.pL...st..s.....hst...........ll+lSsPlKcpYApppGL...DhpcLLssusYKEpaRt-MIpWu.EcpRppD....s....Ga....FCR...t...shcts...........spslhllSDsRRhsDlpaFpptas.......sthh......................................	0	32	52	78
+3625	PF04699	P16-Arc	p16_Arc; 	ARP2/3 complex 16 kDa subunit (p16-Arc)	Waterfield DI, Mifsud W, Finn RD	anon	Pfam-B_4180 (release 7.5)	Domain	The Arp2/3 protein complex has been implicated in the control of actin polymerisation.  The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc.  The precise function of p16-Arc is currently unknown.  Its structure consists of a single domain containing a bundle of seven alpha helices [1,2].	21.90	21.90	22.90	22.70	19.60	21.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.89	0.71	-4.20	36	389	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	277	15	237	330	3	143.80	37	92.13	CHANGED	psaR+lDIDsh-.-sh.c.stps............spsphtsptsplRshLpuGchttALphsLpssPhsucs.psK-tthpsVl-VLsuhKs....s-.IsshlcsL.....sppph.DsLMKYlYKGhusPs...............................stsp................hulLLsWHEKllpluGlGsIVRshoDR+TV	..........................................................................s.taRplDlDth-.pp..p.p....t..............st....sph......tsptspl.cshLp......p.....G.....ch.htALpssLc.s..s.Plssc....s....ssK-tshthVlcVLt..uhKs....s-...lp.psl.puL......spsth.DlLMKYlYKGhptss.......................................................psss...................................ulLLpWHEKhhthuGlGsIlRVlTsR+pV.........................	0	69	116	181
+3626	PF00864	P2X_receptor		ATP P2X receptor	Bateman A	anon	Pfam-B_1590 (release 2.1)	Family	\N	19.60	19.60	24.30	19.70	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.38	0.70	-5.75	19	762	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	78	7	284	674	19	263.70	36	83.68	CHANGED	F-YcTsK.Vll+shplGll.RllQLhllsYllGWVFlacKGYQppDssl.SSVhTKlKGluhsN.s........hht+lWDVADYVlPsQGsssFFVhTNhllT.sQpQGpC...........PE...lP-......stCspDss.CptG.sshtusGltTG+Cls....hss..sh+TCEIhuWCP..sEs-pt.Pss...shLtpAENFTlaIKNsIpFPpFshoKpNllsshssoalKoCpYctp..psPaCPIF+LGsllccuGpsFpclAhpGGllGIpIpWsCDLDhshppCpP+..YSFpRLDsp......pslSs.GYNFRa................................A+YYpc.sGsEhRTLhKuYGIRFDllVsGpAGKFslIPThlslGSGluhhGluollCDllLLahh..................+ppcaY+pKKFEplpcsp.phstpp......pt	..........................................................................................................................................pYpT.+.hhhpshphGhh.hhhphhlh.Yh.h.................a.shl.pKtYQt.-.......SoVhoKlKG.hs.hp....................................plhDss.-Ysh.P................p.........t..ssh.lh..Tph.hT.tQ..thC..............sE...................t......h.C....pDtt...C......G.............................u......p.G..h........TGpCl..........t.....tTCEl.uWCP.h.E.tt...........p...........hh.tA.sFTlhlKN.......pl.aPh..ap..hp.......p.......tN.....l.h........th....s.....t....Chap.....p....C....PlFclG.lhp.s......G.ts...F.........pp.........hA....p..........G.......GhhGl.ItWsCsLDh....p.C.Pp..YpFp.tL-..............h.....GaNF.R.a................................A+aah..........s......s..phRsLhKsaGIRhDlhV.Gp..uGKFshl.hhh.hssshs.h.Ghs............shhhDhlh..h......................t...Y.ttKhp.h............h...................................	1	76	97	158
+3627	PF04045	P34-Arc	p34-Arc; 	Arp2/3 complex, 34 kD subunit p34-Arc	Wood V, Finn RD	anon	Pfam-B_9846 (release 7.3);	Family	Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc [1].  This family represents the p34-Arc subunit.	19.70	19.70	19.70	20.20	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.77	0.70	-5.09	27	380	2009-09-11 15:40:12	2003-04-07 12:59:11	9	9	288	15	254	369	3	223.70	41	65.50	CHANGED	hlSlplKsap-LhptG......s.chLppcYushh........sssEsGYshoLhlDLp..phs.....ptpppllpcluhLKRsshAuPFcpsFpt.tphsp...................spphhsI+YRs..DEolYlcsptDRVTVIFoTlFpDEsDplhGKVFLQEFV-AR+ps...QoAPQVLaSH.-PPLElpshsssp......ss-shGYlTFVLFPRHhsptcpppsoIspIphFRsYhHYHIKCSKAYhHoRMRtRVs-FLKVLNRAKPEsts	..........................................................................lSltl+happL.paG......ApchLpctYGshl..........sssEsGYsholhlDLp..plP...............psp...........ppllpphuhLKRNshAusFEchFph.tphpp...................stphhsIpYRc..-EshYlc....s........ptDR.VTVlFSTlF+D-sDhlhGKVFhQE..Fh-..uRRts.........psAPQVLaSp.....-PPLELps.ssst.........sssshGYlTFVLFPR.H.spsptptpoIshIphFRsYhHYHIKCSK....AYhHoRMRt+sssFLpVLNRA+P-s.p..........................................	0	79	133	205
+3628	PF00067	p450		Cytochrome P450	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures [6].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	463	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.40	0.70	-5.97	50	39592	2009-11-03 19:16:01	2003-04-07 12:59:11	17	282	2977	873	20665	39656	2722	330.60	17	79.49	CHANGED	Psss..shPlhGshhplth....pphhtp.hpphpccY..GslaslhhGs.pshVlltshchl+clLhcps.thssc.t.shhtp...hhpspGlhhsss..scW+phR+hhhsshpsh...ph.shpphlpcpuppLlcplccpssps......hDhtphlsphshssIsslhFupphs.hp-pp...........h.phhphhpphhp..hhts.hhphh.hhs..hlhhhsspht+hhppshphhpshhpphlcc+cpslsss.................p.hDhlchhLht........tppst....phopcsltsslhslhhAGs-TTSooLpasLh.hLhcaP-lQc+lpcElcpll.Gptc.........tsshpDhsphPYlcAsl+EsLRhhslsP...tlsRtspp...Dsplps...ahIPKGTpVhlslhult+Dspha.ssP-pFcPpRFLscps................h.tpshtalPFusGhRsClGctlAchEhhlhLsplLppFplc..s.ss.hsh.pt.....llhhs.shplph	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................................................................................................................................................................................................................................................................................................................h................................+...t......h..................h............................................................h...............................................h........h.....t...........h.....................................................................................h.............h............................t.............h...................h...........h.....h.s..........................................................................................................h.......................................................................................................................................................................................................................................................................................................................h..............................................t........................h...........t.....h........h.....................t......h.....h......t.........t....t..........t.t..t.t........................................................................s...h....h....p......h...ht.....................................................h...s........p...p....l........h......t.................h............h......................h......h.........h......u.................G.........................-.....T..................o....s.........s.......s....h................t....h..h....h............h......l.....h......p....p....P...............p....h..........................p....p.........h.................p.....E........h.............t....h.....h....t...t......................................t.....t...t.......h..............p......h.............h.........h.......p...............t.............s.l...........p..............E........s.............h............R........h..........h..............s....s............s..........s.....................h..........h.........................R..h..s...h.p........................s.....h...........p.................l.........t...............s.....................hh.l........s.............t.................G..................s.................h...........l.........h..............h..........s......h...............h...................s............h..........p................+.............s............................p................h..........a....................p...............P...............p........p.............F...p......P..p......R...a......t...tt..................................................................t....h.....h.......s.........F....u.........h...............G............................+........................Ch...........G.......t............t................h...A..........h........hp.....h..........h.......h......h...h....s....t...l...l...t....p...a...p.h................................................................h................................................................................................................................	0	5443	11134	16825
+3629	PF00870	P53		P53 DNA-binding domain	Bateman A	anon	Pfam-B_782 (release 3.0)	Domain	This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.	20.30	20.30	22.60	22.60	18.80	20.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.31	0.71	-4.71	7	550	2012-10-03 00:25:27	2003-04-07 12:59:11	13	15	172	206	160	635	0	158.10	54	43.93	CHANGED	soVPossDYPGsasFcLpF.Q.SuTAKSVTsTYSPpLNKLaCQLAKTCPlplhVspsPP.GshlRAhAlYKKsEHVs-VV+RCPHHppss-.s-t.hAPsuHLlRVEGN.hupYhEDs.ThRpSVhVPYEsPQlGoEhTTlLYNaMCNSSCMGGMNRRPILTIITLEs.-GplLGRRuFEVRlCACPGRDRKTEEcsh	.................................................lPs.psY.G.atFpl.......tF...p....os..s.s.K....SsshT................YSs....LpKLasp..lAKT.CPl..plhl.....s....s...P..P....G...s...hlRAMslYK+spHhsEVV+RCPpHchs..p.-.....s.-s....hs.s.....s..pH.....LI.RVE...G..s.....tu.pY....h....-....D............T....h..RpSVlVPY....E...sP.p.....l...G.o..-......h.....T..T.lhY....saMCN.SSC..h...G..GMNRRPILhIlTLE.....s.........t...s...G.plL....GRpshEsRlCACPGRDR+s-Ecp.h......................	0	40	49	92
+3631	PF04636	PA26		PA26 p53-induced protein (sestrin)	Mifsud W	anon	Pfam-B_5416 (release 7.5)	Family	PA26 is a p53-inducible protein. Its function is unknown. It has similarity to Pfam:PF04636 in its N-terminus.	29.40	29.40	36.00	33.00	28.20	28.30	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.58	0.70	-5.79	13	327	2012-10-01 19:19:04	2003-04-07 12:59:11	8	4	116	0	185	285	7	362.70	43	81.45	CHANGED	tpGPSsFIPsp-llphsstscpppthhp-sh...GRh..........DplopVhGhHPpYLcpFh+optalhphDGPLPhsaRHYIAIMAAARHQCSYLVshHpp-FLpsGGDspWLpGl-asP.KLRpLs-lNKlLAHRPWLIsKEHIptLlK....s.GpssWSLuELlHAlVLlsHhHuLuSFVauCGlp.-hD.h....tstshps.........ss..spsps..............ph.sssshsssptstus....................................t-VEtLM-RMKcLpcp..pc-EuSpEEMsT............RFE+p+ppohhVh.........suscptcssssssluRal-DssFGYpDFuRRGppslP.TFRsQ.....DYoW.....................................EDHGYSLlNRLYs-l.....GpLLD-KFpsshsLTYpT...............hAs+ssVDToth.......RRAlWNYlpClaGIRaDDYDYGEVNQLL-RSLKsYIKTssCaPE+sTpc.YssahhpF+HSEKVHVNLLLhEARhQApLLYALRAIsRYMT	........................................s..............................p.hh.cth..t.G...Rl..........Dpls.VMsh.HPpYLpsFh+ophhlL..ph..D...G.P.Ls..h.aRHYIuIMA.AARHpCsYLlshahs...cFLp...s.......G.....Gs.....s........p........WL.p.G.L......c..sP.tKLppLs-lNKlL..AHRPWLlo.+..-.HIptLl+........................s..tcpsWSLuELl.pAlVLLsHhHuLu.SFsFGsG.lpsE.hc.....thu..s.hp..........................ss.sp.p..s....................................sss.st..p...t.....s..........................................................-lEsLMc+M.+..p..Lp...cp....p..p-ps..o.......pEE.hts..............................RF.Ehp+ppohhsh............................ss...c.....sl..pah-Ds.sasYp.DFs+..............+G..p....P..TFRsQ......DYsW.....................................E-HGaSLl.s..RLYs.-..h.....GpLLDEK....F....phshs....LTYsT...............hu..h...+ps..VDTo.hh.......RRAlW...NYlpChaGI.RaDDY....DY.G.ElNQLL-RshKlaIKTlsChP.E...+s..Tcc.Ysth..h..cp...FcaS....EKV.HVNLLlhEARhQAtLLYALRAIs+ah....................................................................................................................................................	0	56	73	122
+3632	PF02251	PA28_alpha		Proteasome activator pa28 alpha subunit	Bateman A, Mian N	anon	Pfam-B_2837 (release 5.2)	Family	PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the alpha subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.	21.10	21.10	21.20	22.70	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.11	0.72	-3.80	18	310	2009-09-11 04:56:17	2003-04-07 12:59:11	13	5	109	7	133	251	0	61.10	41	23.66	CHANGED	lss-spt.KV-sF....+ppLppEAEpLlusahPpKIhcLDsL.LKsstlNlpDLosl+us..LsIPIPDPs	.................p.-spt.cV-sF....RppLhpcAEpLlssaFPpKIhcL-sh.L.....+-stLNlp-Losl+u..s..LsIPlPDP........................	0	28	37	74
+3633	PF02252	PA28_beta		Proteasome activator pa28 beta subunit	Bateman A, Mian N	anon	Pfam-B_2809 (release 5.2)	Family	PA28 activator complex (also known as 11s regulator of 20S proteasome) is a ring shaped hexameric structure of alternating alpha and beta subunits. This family represents the beta subunit. The activator complex binds to the 20S proteasome ana simulates peptidase activity in and ATP-independent manner.	20.90	20.90	21.30	20.90	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.69	0.71	-4.74	16	411	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	150	7	201	352	1	137.60	43	56.79	CHANGED	ssG..hlssNcplhpllcplKPElppLhEphshlphWIQL.IP+IEDGNNFGVuIQEcslpclssVcocstuFhspISKYaspRGchVuKsuKhPHVtDYRphV+ElDE+pahpLRlhlh-lRNpYAhLaDlIhKNh-KIp+PRus..sptthY	............................................sG.l.sNcplh.sllp.hlKPElppLhEphsh................VphWlQhhIP.+..I..EDGNNFGVulQ.........Ec.s...lpclpslcocstua...hspI..S+Ya.pRuchVuKsuK.P.H.....V.....tDYRphVpEhDEtpYhplR...............lhlh-lR.NhYs...LaDlI....KN...h...EKlppP+up..pt..hY.................................................................................	0	70	89	138
+3634	PF05138	PaaA_PaaC		Phenylacetic acid catabolic protein	Bateman A	anon	COG3396	Family	This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid [1]. These proteins may form part of a dioxygenase complex.	27.60	27.60	27.80	28.70	27.40	27.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.49	0.70	-5.43	117	1413	2012-10-01 21:25:29	2003-04-07 12:59:11	7	4	637	42	464	1179	369	266.20	33	88.22	CHANGED	M.................................................thppsLhchlhphADssllhupRhuEW...hu+APsLEc-lALsNhu.D.lGpuphhashAtp.......................L.....s..G..........pscDcLAahRpstca..+NhhLhEhPss...........caApohsRpaLhDuhthhhhpsL.ppSo.sslAtlAsKssKEtsYHh+put-hlhpLu.cGTcES+p+hQsAlsphW.ash.-hFsss-s-.................pshtttGhssssspLRppahsplsshlp.pssLslP...c.....st.hphs.G+....pG.pHo-thGhl................LschQhhpRuaPsu.sW	...................................................................................ttttp...................thcpsLhc.lhphucopllhhp.tu.p.W...hs+APsLccchsLhshs.DphGH....uh.hL.aohA.tp.......................L..........G...............tsc.Dc.lh.th...p..st.ch...+.......sl...hph..Psh.............saA.DshshsaLlDuhtlh..ssL..scoohsshAphhs+.h.hKEpsaH.RpuhchlhpLu......pGT.....c...tp...+phhQpAlschWh.sh..hFsss...-sc....................puh.s.h.th.h.t.h.s.s.cp.LRppahspssstlp...hs.LslP...s...............ss....h....phs....sc....pG.tas...G.l.................htchphhp+ua.tu.tW...................................................	0	123	282	386
+3635	PF02758	PYRIN	PAAD_DAPIN;	PAAD/DAPIN/Pyrin domain	Bateman A	anon	Bateman A	Domain	This domain is predicted to contain 6 alpha helices and to have the same fold as the Pfam:PF00531 domain.  This similarity may mean that this is a protein-protein interaction domain.	22.40	22.40	22.90	23.00	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.52	0.72	-4.28	38	767	2012-10-01 21:41:45	2003-04-07 12:59:11	11	56	60	11	298	774	1	81.90	26	11.69	CHANGED	tchhLlpsLEpLscc-hccFKthL............ptsphpIspspl-p.ss.chclAsLlhppaspctAhshslplhcchspp.cLsccLpc	........p.tLhphLEpLs..cp-hc..cFKhh.L..................ppst.tplPh....s.pl-p..As..thclAslLlppa.stptAhphslplh..cchspp.-Lscchp....................	1	23	69	115
+3636	PF00658	PABP		Poly-adenylate binding protein, unique domain	Bateman A	anon	Prosite	Family	The region featured in this family is found towards the C-terminus of poly(A)-binding proteins (PABPs). These are eukaryotic proteins that, through their binding of the 3' poly(A) tail on mRNA, have very important roles in the pathways of gene expression. They seem to provide a scaffold on which other proteins can bind and mediate processes such as export, translation and turnover of the transcripts. Moreover, they may act as antagonists to the binding of factors that allow mRNA degradation, regulating mRNA longevity. PABPs are also involved in nuclear transport. PABPs interact with poly(A) tails via RNA-recognition motifs (Pfam:PF00076) [1]. Note that the PABP C-terminal region is also found in members of the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains - these are also included in this family.	21.00	21.00	21.20	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.17	0.72	-4.31	38	874	2009-09-12 06:34:48	2003-04-07 12:59:11	13	31	321	31	523	833	28	70.80	49	9.26	CHANGED	tshsAuhLAsAsPpp.......QKQhLGEpLYPhI....p........phpP..-hAGKITGMLLEhDNsELLpLLEss-sLcsKVsEAlsVL	...........................hushLAsAs.Ppp...............QKQhL......GE+LaPlI....p.........................shps.....phAGKITGMLLE..h..D...s...oE....L...LphLES.s.-...uL+uKV..-EAlsVL...................	0	158	255	394
+3637	PF03068	PAD		Protein-arginine deiminase (PAD)	Mifsud W	anon	Pfam-B_2195 (release 6.4)	Family	Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognised (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen [3].	25.00	25.00	26.30	27.30	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.39	0.70	-6.04	7	323	2012-10-01 20:45:11	2003-04-07 12:59:11	10	8	86	12	176	305	2	310.40	44	60.02	CHANGED	sLsEsslFTDTVsFRlAPWIMTPNT.PP.EVYVCplpD....N-cFLcslspLspKApCKLTlCPp.ENRsDRWIQDEMEhGYIpAPHKohPVVFDSPRsRGLKDFPlK+lLGPDFGYVTRE..hsssSuLDSFGNLEVSPPVTVpGKEYPLGRILIGuS.aPpSsGRcMspsVRDFLpAQQVQAPVELaSDWLsVGHVDEFLSFVPssDpKGFRLLLASPuACapLFQEKQctGaGEAhhF-GL+tppp....oIscILuscpLpcpNtasQpCIDWNR-lLKRELGLuEuDIIDIPQLFphcptt.....AcAFFPsMVNMlVLGKaLGIPKPFGPlINGRCCLEEKVpSLLEPLGLpCTFIsDahsYHhhtGEVHCGTNVRRKPFuFKWWpMVP	................................................................................s......lapDoVhFRlAPhlhpPsh..P.plals..p..h.hp...........p........Flct..ltt.l.st...pst.hp..l...hl...s...p......s.p.s.DpW.hQD.....chEhG.Yh.....ph......P.....p....p....s....h......s....V....l....h.......c.....o.P...R.s.ttL.....p..c....F..s....h.+..plh....u.s.shG..aV.s...p.t.................t.....t...s..ssl.DS..hGNL-VSPP.lss.t.G.KpYPhGRIlhGss...hs....t.....t.u+phtpslpsFL.AQ.pVQ.sPlc.LaoDWLhVGHVDEFhsFlPs....s....s....p....KGFp...hLlASPpushcLhpctpppG......aG......cs..h..h.....F.......p.................u...lt.......t...............t.....p........................oIsplLusc..pLh..ptNtas....p...p.s...I.........chNR-lLK+ELGLs.EpDIl-.lPtLFph......p.p...............................A.....AaaPsh.VNMlV.L.....s....+.p..LG....I..PKPaGPh........l.....p..GpCsLE..pclpsLlcsLGhpCsFIDDa.sYHh.h...hGElHCGoNV.pR.pPFsa.KWWp..........................................	0	12	52	89
+3638	PF04371	PAD_porph		Porphyromonas-type peptidyl-arginine deiminase	Kerrison ND	anon	COG2957	Family	Peptidyl-arginine deiminase (PAD) enzymes catalyse the deimination of the guanidino group from carboxy-terminal arginine residues of various peptides to produce ammonia.  PAD from Porphyromonas gingivalis (PPAD) appears to be evolutionarily unrelated to mammalian PAD (Pfam:PF03068), which is a metalloenzyme.  PPAD is thought to belong to the same superfamily as aminotransferase and arginine deiminase, and to form an alpha/beta propeller structure. This family has previously been named PPADH (Porphyromonas peptidyl-arginine deiminase homologues) [1]. The predicted catalytic residues in PPAD (Swiss:Q9RQJ2) are Asp130, Asp187, His236, Asp238 and Cys351 [1]. These are absolutely conserved with the exception of Asp187 which is absent in two family members.  PPAD is also able to catalyse the deimination of free L-arginine, but has primarily peptidyl-arginine specificity.  It may have a FMN cofactor [2].	25.00	25.00	28.80	27.50	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.07	0.70	-5.39	22	1778	2012-10-01 20:45:11	2003-04-07 12:59:11	10	7	1418	31	444	1482	890	324.50	33	93.65	CHANGED	a+MPAEapPppusahsWPp+s-sW..ttthtsAptsasslAcAIu+h.........E.VplsVsssp...htsARthLss.........slcllchshsDuWhRDsGPsallssp.......G.chc..slDWpFNuWGGhh.....sappDspVupplsclpthshapss......alLEGGuIcsDGpGTlLTTcpCLLs.sRNPpLo+tpIEppL+caLusp+llWLtcGhhts...-.TsGHlDslspFlsPupVlhshs-DtsDPpYthhptshchLpshpDAcG+.hplh+lPhPs..................th.cpsG-RLsASYsNFhIsNsullhPtasDs.sDphAhclLpphFPc+clVGl.suRcllh.GGGslHCITQQ.P	................................................................hhPuEap.pptshhhW.P...p.c.....s.s...W........t......t...h..p.....sp...p...sa...s...p....lspsI.uch.........-..Vh.l.hst..ptp........htp.s.p...p.hlsp.......................plp.h.l...c..h...s..s..s..D..s..WhRDpGPhhl..hs.sp.............................u....p....ht.......slD..as..F..N.u..W..Gsph................................shc.p.D....s.p....l...s...p...p...l..s....c.....h....t....t....h..s.....h...h.pss...................hlLEG.GuI....cs.....DG..p....GTlLsTc.......pCLLs.........s....R..NPp....L................o.........+.p.p..I..Epp.LpchL...G..l.c.........+lI..WL...s.pG..h....hts....................-.....Ts..uHlDslspFl.....sssp..........llhs.......h..s.......-..D.p.......s.......D.......s.......p.......Y..t.h.hptt.h.chLppt.pcsc.....Gp.hplhcL..PhPt.......................................c...sG....c...R.L...s..A.S..YsNFh.lsN............s....u....l.l..........l........P..ta........s.........D........s.....s.........D......ph.A.hchLpphF......P.s......+....c..l.l.Gl.ss....c.pll....h.tGGslHClTQQ.P......................	0	159	301	392
+3639	PF03551	PadR		Transcriptional regulator PadR-like family	Bateman A	anon	Pfam-B_1014 (release 7.0)	Family	Members of this family are transcriptional regulators that appear to be related to the Pfam:PF01047 family. This family includes PadR Swiss:Q9EXE6 a protein that is involved in negative regulation of phenolic acid metabolism.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.38	0.72	-4.21	33	8479	2012-10-04 14:01:12	2003-04-07 12:59:11	9	19	3006	28	2200	6899	485	72.50	28	49.56	CHANGED	lLtlL.sc.psh..aGYplhpclcph..Ghhphs...cGoLYPhLc+LEccGLlssphppt..htu.sRKhYpLT-sG+ptLpc	................................lLslL..tc..pst...aGY.-.lhp..p.l....c....p....h...............s..h...h...p....h..s.........tG...olYshLp+L.pcpuh.l............p.........s....t......h.pp.............t..............tt....sR.....K...h.Y.p..lT..cpGcptLt............................................	1	832	1595	1975
+3640	PF03283	PAE		Pectinacetylesterase	Mifsud W	anon	Pfam-B_1589 (release 6.5)	Family	\N	22.90	22.90	22.90	23.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.18	0.70	-5.82	27	583	2009-01-15 18:05:59	2003-04-07 12:59:11	8	11	204	0	340	545	102	274.10	26	69.61	CHANGED	hhhhphs..hssp...................VtlsllpsAhtcGAlCLDGShPuYHhccG.GoGussWLlphEGGG.WCss......hcsChtRppT..chGSSphh.ppplsFs....GlhSspsppNPDFaNWN+VplRYCDGuSFsG.csc...spuspLaFRGp+IapAlh--Llsc.GMppAcpslL.oGCSAGGLusllaCDp....F+shLPt....sspVKCloDuGaFl...DshclsGscshcpha.....psllplps.tpslspsCss+hpPs........CFFPQpllptIcTPlFllNuAYDsWQlpphLsP.ss..tt.WttC+hs...hspCsssQlphlpsFRsphlsulpsh..tpsppsGhFlsSCasHCQotpptoWhsts..SPhlpspslAcuVGDWaasRp..hctl	...................................................................h.........................................tshC.DGo.s..ua..a..hp.u..........tu.s.p.p.all.hp.....GGu.hC.s..............hpsC........R.....ht.s...........thho...S..p......h.......p...t.h...hs......................Gllus.p.t.tNP.aas..WN.hVhl.YCsGssasG...s.......s.....p........................................................p...............t...............s..............t.........p..............h..............hapGtpl.........hp...s...lhpcLhsp.....Ghtp....A....p.........p.h..lL.sGs..SAGGhushlpsDp....hpph.hst............sspV.+sluDu..G.hFl.........................s......th..thtt..ht.h...........t.hh......t...h..p.......tt.hst.C...t.h..t.............Chas..hh......hps.Ph..Fhhp.haD.hQh.t.......................................hp..t....ph.hhptht.thht..h................u.ahsuCh.Ht...............a...................htt..........h...h..............h.................................................................................................................................................	0	128	217	285
+3641	PF03403	PAF-AH_p_II		Platelet-activating factor acetylhydrolase, isoform II	Mifsud W	anon	Pfam-B_3469 (release 6.6)	Family	Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in Pfam:PF02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.42	0.70	-6.17	7	427	2012-10-03 11:45:05	2003-04-07 12:59:11	8	13	218	13	281	1346	263	295.60	23	70.00	CHANGED	huupspsplPtssGPasVG.............CsDLMhsts....cusFlRLYYPs...p.-psp.-sLWIPpcEYh.GLu-aLss.phhGplL.phhhGShphPsphNush+ss..-K.YPLllFSHGLGAFRTlYSAlshpLASpGFlVAAVEHRDcSAusTYahc-tsssE.t.......pcpWlhh+chpt.-pEhplRpcQVpQRspEC.pALshlhpIs.tGpsscNl.....LsssFD...hppLKsslDpo+..lAVhGHSFGGATsl.......poLuc-....pcFRCuIALDsWMaPlsc-ha.Sph.QPlhFINStcFQhstslhpMKK......................hhs.ccpp+hITlcGSVHpsFsDFsFloGclIG+hhpl..KGclDsp.Ah-lss+ASLAFLQKaLsLcc-asQWssLh-G.spNl	.......................................................................................................h.............G....lG....................................t.....................t...h.....plaYPs....................t.....................ah..s...........t................s.h.......t..t..h...h...............t...h............h..h................h..................h..h....t......................h.p..h..s..s.........ss......h.............t..................st..............t.....p..aP.lllFSH.G....l..u...u.....R.ph..YSt.hshpLASp...GalVsslE...H......p.....D.tS.....us.h.o..h.h......p..............tt...................t.................................................................................................h.........t....t.................t..h....thRptQ.lp.R.....h.tE......h....shp..hl...ths....tG..p............h.........................h......t..p...........h...t.h..psp....ls.h...pp.........lshhGHSFGu.ATsh...........................................tsh.pp................p.h...p...s.....sl.hl.....Ds..a...h.......h...s......l...t.........p......t............................t.........h.................................P.............h.....h.hl.p....s..p....t...a......................t........p.............................h..p.......................................................................................................h..................t..................h.....h...h...h.....t.s.H.s.sDh..h...h......s....................................................................................................................................................................................................................................................................................	1	109	170	222
+3642	PF03985	Paf1		Paf1 	Finn RD, Wood V	anon	Pfam-B_ (release 7.3)	Family	Members of this family are components of the RNA polymerase II associated Paf1 complex.  The Paf1 complex functions during the  elongation phase of transcription in conjunction with Spt4-Spt5  and Spt16-Pob3i [1,2]. 	20.40	20.40	20.50	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.59	0.70	-5.74	12	358	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	263	0	255	360	4	334.60	24	76.57	CHANGED	p-aIs+l+YpNsLPsPshsPKhlpash....spsh.sp.hloSLhpcpphssLh...DpDLGhslDLl.........Dpchhts.s.ssp...LcscDchLL+Dsthsp.........ho+pc.ptVoaLR+TEYIS...sp.sp.t.....stcthpschthslcpshpppp..hhstpp.lctlEpTF-sspp.....phhpHssK+plpsVcshsLLPDhsphcpsahplpFsGss..........shstp-tp.........p.thpsslhtsh-hEt-caluhahs........hpppL-cphcDhp........cppc.YcaKhhR-Yshphhp...........psthp-hslhhs............pcpsssYYpPLcoRlcL++RR......lc.lVpppshsplslphRsssspEpchpcthRtch-shshsph--.E-Ec-ct.p.ppc.pcspspppptttptps.pptt...........tp.t.ctppttcptpsssotss	....................................................................................................................................................thlspl+YpNsLPs.shsPKhlphsh.......tt........phh.s....h.hh.os.Lt+p.phph.....-.-lGhslD..L.l.................s.....phh.....h..s......s...............lcPtDp.LL..c..p...h................................................psp..pt.ts.V.saLR+TpYIS..........st...s.t.t....................s.pt.php..h....thp.hp....p.t............t.....s...p.t....l.p.t...I-p..oFpsspp....................................tH.....s...+....p..lpsVphhPlhP..Dhpha.....p..s..hh.lhFsssP...............................s.t.tt.....................t.h.p...shl.h..........t..........t.........p........p....pa..h..s..h.....ah...s..............................h..t.p...h...p.....t.t-..................t...t........p..a.p.......aphhRpYph.php..................tpth.-....s.hhhh........................c.tpssaY..l..s.+hpLppcR....................t..h............p........t......s.l........lph+.t..st.t.....-...t..p.h..p.h.t.....t......................................................................................................................pttt...........................................................................................................	1	81	135	206
+3643	PF02671	PAH		Paired amphipathic helix repeat	Bateman A, Mian N	anon	Pfam-B_281 (release 5.4)	Repeat	This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene Swiss:P22579 (also known as SDI1) that is a negative regulator of the yeast HO gene [1]. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.	21.30	21.30	21.60	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.13	0.72	-4.34	121	1587	2009-01-15 18:05:59	2003-04-07 12:59:11	16	30	270	12	991	1522	9	48.30	34	10.07	CHANGED	sphYppFLclLptapp.pphstsp.................lhp................c....Vsp.Lhp.....sa..-Llp...tFsp.FLs	.................................................chYppFLcllpp.app..pp..lstst.........................Vhp................p.....Vsp..LFp.....s.as..-Llp...tFsp.FLP...............	0	344	546	754
+3644	PF00221	Lyase_aromatic	PAL;	Aromatic amino acid lyase	Finn RD, Eberhardt R	anon	Prosite	Family	This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities [1-3].	21.80	21.80	22.20	22.00	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	473	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.48	0.70	-6.05	143	3331	2009-12-15 11:53:36	2003-04-07 12:59:11	14	13	2194	102	901	2989	703	434.10	35	86.47	CHANGED	lpl.suss.Lolspltslu....p.ps...tplpLs..spuhpclppupphlp.chlpps.pslYGlsTGFGthusscI..s.........cc...htpLQcNLlhSHusGlGp............................................slspshlRshhllRlsoLu+G.....aSGlRhpllctLhph.LNpslhPhlPppGSlGASGDLAPLAHluhs.llGc.Gcs.hh.p.......Gp..................h.....hsu.s-ALppsGlpP..l.pLtsKEGLALlNGTpshoAlushulhcAppLhthAtlhuALohEAlpGsspsFcsplH.tl.RsH.GQlcsAstlRplLp.G...S......plhpscp....................+..............lQDsYoLRChPQVhGAsh-slphspcslphEhN..usoDNPLlh...........s....-...............t.s.......cl..lSGGNFHupPlAhAhDhlslAluclGslu-RRlspLlssths.G.LPsFLs......s....ss.GLsSGaMlsQhouAuLsSEN+hLApPuSsDSls.oSusp..EDHVSMushuAR+h.tchl-NlptllAlELlsAsQAl-hR........t.....shph.usshptlhphlRppVshh..p...p	..........................................................................................................................ltstpLoltplhtlh......p.....ts......spl.pls...tpuhttlptut.thlp.p..hh......t...p.s.p................s...sYGlsTGFG.thu...shpl..s..................cphtpLQ...csLlh.SHusGlGt..........................................................shspphsRhhMll+ls..o.LspG.....aSGlRhpllptlhth.lNt.slhPhlPt..pG.SlGASGDLsPL.uHhuhs.Ll.GcG...cs...hh...p...........Gc..........................hhsutcu...LpttG.l..p..P.....l.p.LtsKE..GLALlNGT.ps...ouhuhhulhcAppLhthuplhuAhohEuht.....Gp.psFc.t..p..lH.t.l.Rsa.GQ.hpsAtthRp..l..Lp.u........S.....plhppppt.............+...................................................lQD.sY....o.LRC.PQlhGush-slp...hstphlp.hEhN..u.....ssDNP....L.lh......s....c.............................................................t.s....cl..lSGGNFHu.pPlAhuhD..LtlAlAcluslu-RRhstLlssth..s.....s..LPsFLs......s.......ps..GlsSGa.M......l...sQh..ss.Auls..SEs+t.LApPuS..l.DS...hs.ouspp........ED..+VSMushAuR+h.hchl-shptllulE......hlsAsQ...ul-hR........t.....s.p.......ush.h.pps.hp.hhRphls....p...........................................................................................	0	266	520	727
+3645	PF02089	Palm_thioest		Palmitoyl protein thioesterase	Mian N, Bateman A	anon	IPR002472	Domain	\N	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.93	0.70	-5.47	2	572	2012-10-03 11:45:05	2003-04-07 12:59:11	10	11	252	6	338	538	22	229.00	32	83.50	CHANGED	DPPuP.PLVIWHGMGDSCCNPhSMGsIKKMVEKcIPGIaVLSLEIGKshhEDVENSFFLNVNsQVshVCQILtKDPKLQQGYNAhGFSQGGQFLRAVAQRCPoPPMhsLISVGGQHQGVFGLPRCPGESSHICDFIRKoLNAGAYsKhlQERLVQApYWHDPI+EslYRNaSIFLADINQERsVNESYKKNLMALKKFVMVKFhNDoIVDPVDSEWFGFYRSGQAKETIPLQESTLYTpDRLGLKtMDKAGpLVFLAhEGDHLQlScEWFhAHIIPFLc	.............................................................................PhlhhHGh..............h..Dp........sh......t.h.....p...hhp..p.....h.s.Gh...hshslpl.s.p..............s....s....tsh..hhplptQhp.ls.p.............lt.p.........L..t..p.....G...hshlGaSQ...Gu.hhRulhpps.s.....s.....s.h.....p.................shIolu.u.p......tGhhuhs..h..C................t......h.......h.C..phh....pphl.p.h.ts.Ysphs...Q...ppls..upYa+...D..P..h...c..........s......Y..h...pt...S.FLs..clN.s..E............p...................h............N..p.....s.....Y......+........c...Nh........hpLp...phVhlhF....sDshl..Php.Sp..aFG....aa.........t...ss.t..........p.p..h...........h.sh...pcp.t.lYtcDhlGL+ph.cptGpl.hh.hs...h...G...t.H...h....t.....h..s.....t...............................................	2	127	185	265
+3646	PF02569	Pantoate_ligase		Pantoate-beta-alanine ligase	Mian N, Bateman A	anon	COGs	Family	Pantoate-beta-alanine ligase, also know as pantothenate  synthase, (EC:6.3.2.1) catalyses the formation of pantothenate from pantoate and alanine [1].	20.70	20.70	20.80	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.87	0.70	-5.64	7	3517	2012-10-02 18:00:56	2003-04-07 12:59:11	10	12	3268	96	934	2614	2426	268.30	42	94.43	CHANGED	hplhpsltplpphp.+phR.p..t+plGFVPTMGhLH-GHhsLlcpA+.tcNshVVVSIFVNPsQFGssEDh-tYPRsl-cDhtlhEptsVDllFsPssc-MYPtshpsplp.tt.........Lop.LEGtsRPGHFcGVsTlVsKLFNlVpPsRAYFGpKDhQQlhllcphVpDh.hDlEllssPIVR-pDGLAhSSRNsYLssEpRKtA.uLY+uLptutphlps....GE+sspclhptht.tl....lcttpsh.lDYlEltDhp..L....-Phpp.cpt..llhVAshlGc.......sRLIDNhhl	..................................................lhpslttlc.p.hh....pp.h..+.tp.......up..pluhVPTMGsL..H-GHhsLlccA+.....p...c......s.....D...............h......V.VVSIFVNPh.QF...u.s...s.EDhspY.P...RsL.pcDhphL..........p..........p............t..................G...............V.....D............h......lFsP.s...s.c-h.....Y....P....p....s........h......p.....s...p.s...p...lss..................................lushL..-G.up..R.P.G.........HFcGV.s.TVVsKLFNl............V.....p....P......D......hAhFGcKDaQQLslI+pMVpDh..s.h.....s.....l.....c.Ilus.P.hlR.-.p..D.....GLAhSSRNsYLo.s-cR.p.tAstL..csLpt.....s..tp....th..ps......................G.p....c......s..h...pt.l..h..ptst....ph.........................Lp..p..t......h....h..plD....Ylplhcsss...L.....................p..s......h......p......p......h......p....p......t......h......ll..h.h.A.shl.Gp.....................sRLIDNh................................................	0	311	620	808
+3647	PF02548	Pantoate_transf		Ketopantoate hydroxymethyltransferase	Mian N, Bateman A	anon	COGs	Family	Ketopantoate hydroxymethyltransferase (EC:2.1.2.11) is the first enzyme in the pantothenate biosynthesis pathway.	25.90	25.90	26.10	26.10	25.70	25.40	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.44	0.70	-5.27	117	3509	2012-10-10 15:06:27	2003-04-07 12:59:11	10	8	3295	45	993	2531	3391	255.50	45	92.45	CHANGED	p..+h...TlsclpphKpp...sc+IshlTAYDhshAplh-puGlDhlLVGDSLGMVlhGhsoTlsVTl--MlaHscAVsRGsp....puhlluDhPFhSYpsoscpAlcsAs+lhc.puGApAVKLEGGt.....thsctlctLsctGIPVhuHlGLTPQslpthGGa.+lQG.+.stpsAppllcDAhuLpcAGAFulVLEslPspLAppITp..pl.slPTIGIGAGsssDGQVLVhpDhLG..l.......sshtPKFVKpYs...shsshlpp......AlppYsp-V+sssFPst-	....................hTlspLtchK...p...p...sc.....+lshlTAYDh..shA+lh-p.s.G.lDllLV.GDS.LGMllhGa-o....TLPVTl--MlaHscAV.tRG.....ut..................p....shll.uDhPFhoYt..s.o.scpAhpsAs+lh+..u.GApuVK...lEG....Gt.........tl.s-.s........lchLsptG.IPVhuHlGLTPQSV......shhG.GYKVQ...G.+.s.....tc........s......A......ppLlpDAhAl-pAGAhh...lVLEs.VPspLApcITc..tL...s.IPsI.G.IGAGs.......s.sDGQVLVhaDhLG.......l...............t...ss.....hhPKFlKpah..............shss....s.lpp..........AlppYhp-V+susFPup...................................	0	329	652	849
+3648	PF02711	Pap_E4		E4 protein	Mian N, Bateman A	anon	Pfam-B_1589 (release 5.5)	Family	This is is a family of Papillomavirus proteins, E4, coded for by  ORF4. A splice variant, E1--E4, exists but neither the function of E4 or E1--E4 is known [1].	20.50	20.50	22.10	23.40	19.00	17.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.81	0.72	-3.17	40	248	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	78	0	0	191	0	91.30	42	90.27	CHANGED	LpLh.ssp.....+YPLLcLLsshp...s....PPp..P.Pp..shAPp+......s+RRl.sD.............sDsssspssssssh.t..........pssWTVpTsssol..olpupTpsGToVsVTL+L	.......LpLs..sss.....+YPLLpLLsoh........T........PP+.hPsPs..PWAPp+.......+RRL.sD.............pDps.p.s.p.psssss................ps.WTVpp...t...ol..pLpApTKcGsoVlVTL+L........................	0	0	0	0
+3649	PF04755	PAP_fibrillin		PAP_fibrillin	Mifsud W	anon	Pfam-B_3698 (release 7.5)	Family	This family identifies a conserved region found in a number of plastid lipid-associated proteins (PAPs), and in a number of putative fibrillin proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.48	0.71	-4.59	12	635	2009-01-15 18:05:59	2003-04-07 12:59:11	7	13	130	0	381	643	102	170.70	22	64.03	CHANGED	tpLKppLl-ulhGp.p.RGLp.Aos-s..+scI.phlppLEuhNPossPs.-s.sLLsGpWhLhYTottslh......sLl.tspl.h.l+ltpI.QsI........Dspshsl.N.sp..htu....PhhpssholsAcFEltSspRlplpFccuhlt...l.....................h.t..t.hpssht.l........Plph.hssspspuWL.sTYLDc..-LRISRGstGslFVLh	........................................................................t......lht.h...t...h..Gh...hp........pp.......ptpl.phlpt......LE.....sh....s.ss.s......t......sh....p........s..................s.........h.LpGpWpLhY...oo..ttthh...................................h...........s.th....h......h.p.....h.s.p...lhQ.tl....................cs..ts....h...p.....h....N..hhp.........h............h.s.......h..p.s.....t........h...plp.u....p..h.p...h......h.......s.......s.......p........+.l......p.l..pFp.ps.hlt........................................................................................................................s.....h....................................t......t.s.p...u.h...h..hTY.LDc......clRls.R..us.t.Gshhlh.h..................................................................................................................................	0	148	296	349
+3650	PF04926	PAP_RNA-bind		Poly(A) polymerase predicted RNA binding domain	Wood V, Bateman A	anon	Pfam-B_1341 (release 7.6)	Domain	Based on its similarity structurally to the RNA recognition motif this domain is thought to be RNA binding [1].	22.10	22.10	22.30	22.20	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.84	0.71	-4.70	54	630	2009-01-15 18:05:59	2003-04-07 12:59:11	10	17	301	11	392	595	5	146.80	29	22.62	CHANGED	sFFpp.YKaYLplhsuupsp-.pphcWpGhVESKlRhLlt........pLEphss.ltlA.HPaP+sFp.......................................................................t...ppppp............................haposaaIGLphpttps.pttp................lDlphsspcFhshsps....h.t..h.tsthplpl..paVKpppLPs.V..atputp+sp+s	.............................................................................sFFpp.YKaYlhlhs..s......us......s......p-..pthpWs.GhVES+lRhL.lt........pLE.+.s.ph...ltl.A..Hs.PpsFs.........................................................................................................................................psppp.....................................apohaa.lGLthcp...s....t.s.t....t.............................p..lDlshsl.ppFpsp.lhp....h.p...hh.ctsh.plts..pHV.+.pppL.phl....th.pc....t..................................................................	0	121	204	312
+3651	PF04795	PAPA-1		PAPA-1-like conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6501 (release 7.5)	Family	Family of proteins with a conserved region found in PAPA-1, a PAP-1 binding protein. 	21.00	21.00	21.90	21.90	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.12	0.72	-3.28	19	276	2009-09-11 14:54:57	2003-04-07 12:59:11	7	9	209	0	180	273	0	83.40	31	21.17	CHANGED	Etth+RAEtARRR+.QuEK+sEEpKh-TIp+LL+ppu.......tt+.tt...tttppshtppcstcsppsssshlRals..utpGopluhPpc.lssP	.................Ehth+RuEtAR+R+..uEK+sEEc.........K.......t-TIp+LLKppu.............tp.p.t.t..p......t.t.t.....pp.....tttpt..c.ttp.tt.ssshlRalp....s..pGshlshP.t.h...........................................................	0	50	95	142
+3652	PF03333	PapB		Adhesin biosynthesis transcription regulatory protein	Mifsud W	anon	Pfam-B_3068 (release 6.5)	Family	This family includes PapB, DaaA, FanA, FanB, and AfaA.	20.40	20.40	20.40	23.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.00	0.72	-4.17	14	275	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	191	2	10	111	1	87.40	42	78.55	CHANGED	hpphst......hhhph+pthLhPGplsEc+FaLLhEISsI+ScKVI.AL+DYLVhGhoRKElCE+asVssGYhShuLsRLp+lsphVtpls.aY	.................t.th...............h+tutL.PGplsEEpFaLLl-ISsI+S-KlIhAL+DYLVpGaSRKpVCE+ashssGYFSsslsRLpclsphVtpLssaY...........	0	1	3	6
+3653	PF03628	PapG_C		PapG chaperone-binding domain 	Finn RD	anon	Pfam-B_3074 (release 7.0)	Domain	PapG, the adhesin of the P-pili, is situated at the tip and  is only a minor component of the whole pilus structure.  A two-domain structure has been postulated for PapG; a carbohydrate  binding N-terminus and chaperone binding C-terminus (this domain). The chaperone-binding domain is highly conserved, and is essential  for the correct assembly of the pili structure when aided by the  chaperone molecule PapD [1,2]. 	19.60	19.60	20.70	19.80	19.00	18.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-10.42	0.72	-4.38	3	75	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	38	2	1	61	0	108.50	73	33.56	CHANGED	HGNLSIDSANGNYASQTLSIYCDVPVoVKISLLSNTpPAYNN.QpFSVGLGNGWDSIISLDGV-puEETLRWYTAGS+TVTIGSRLYGEuGKIpPGsLSGSMTMlMpLP	........HGDLSINSANNHYA..AQTLSVSCDVPsNI.RFhLLpNTsPsYSH.GppFSVGLGH...GWDSIVSlNGVDTGETT.M..RWY+AGTQNLTIGSRLYGESSKIQPGVLSGSATLLMILP....	2	0	0	0
+3654	PF03627	PapG_N		PapG carbohydrate binding domain	Finn RD	anon	Pfam-B_3074 (release 7.0)	Domain	PapG, the adhesin of the P-pili, is situated at the tip and is only a minor component of the whole pilus structure.  A two-domain structure has been postulated for PapG; a carbohydrate binding N-terminus (this domain) and chaperone binding C-terminus. The carbohydrate-binding domain interacts with the receptor glycan [1,2].	25.00	25.00	48.80	48.10	22.10	21.10	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.50	0.70	-4.90	4	66	2012-10-02 17:35:21	2003-04-07 12:59:11	8	2	29	4	1	50	0	216.30	62	66.66	CHANGED	MKKWFPAFLF.LSLSGsNDALAuWpNlMFYuFNDh.shsuGNVplhDpsQFhlsWpoGuATAT..YsuCsGPEFssG..lYapEYlAWlVVPK+V.TpsGYslFl-VpSKhGWS.ENpsDpD.YaFhpGYcWDphsssuuRlCh.sGpp+pLsppFs-lhFplhLPsDLPKGcYshPl+YlRGIQ+HaYsahts+YKhPYs.hKpLPtsNTl.hShcNsGuCRPSAQSLEI	..MKKWFPAhLF.LslSGpssA...hpshhFYShsDs..h.thsVhlTphsQFIsshpsu.uTsT..aspCNG.sascG..hYapEYhAWlVhPK+V.ohNGYslalElpsKGSaS.-sp.DNDsYahhKGatWDE.A.suGplC.p.GEpppLs.p.FsslhhpstLPsDLPhGDYohsl.ahpGhQRp.hsYlGuRaKIP.slhKThPhpsph.F.hKNhGGCRPSAQSLEI	0	0	0	0
+3655	PF03025	Papilloma_E5		Papillomavirus E5	Bateman A	anon	Pfam-B_1916 (release 6.4)	Family	The E5 protein from papillomaviruses is about 80 amino acids long.  The proteins are contain three regions that are predicted to be transmembrane alpha helices.  The function of this protein is unknown.	25.00	25.00	37.90	37.60	21.10	19.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.91	0.72	-4.03	13	139	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	32	0	0	103	0	70.20	58	92.77	CHANGED	llhlFllCFCVhLhlChhl.PLL.SlplaAhlllLVllhW.VshTSPhcsFhVYllFhYlPhaLlHhHA.hhhp	.....LLssFLLCFCVLLCVCLLlRPLLLSVSsYsoLlLLVLLLW.losuSshRsFhVYllFlYIPLFLIHsas.......	0	0	0	0
+3656	PF02380	Papo_T_antigen		T-antigen specific domain	Mian N, Bateman A	anon	Pfam-B_1131 (release 5.2)	Family	This domain represents a conserved region in papovavirus small and middle T-antigens. It is found as the N-terminal domain in the small T-antigen, and is centrally located in the middle T-antigen.	19.10	19.10	20.20	19.80	18.30	17.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.92	0.72	-4.06	10	268	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	63	6	0	201	0	85.00	40	54.97	CHANGED	V.ussasssh-phaCKpWssCh+shs.spCs.CllChL+ppHcp+.KhhR+sPLVWl-CYCa-CappWFGh-loppslhhWspIIupTPhcsLcL	.......................l..t.h....cphasKpWshC.pp.p.scCs.ChhC.LchpHhp+.KhhRKp...PLVWl-CYChcCappWFGhsl.TpE.ohpaW.plltpTsa.p.LcL..................	1	0	0	0
+3657	PF01507	PAPS_reduct		Phosphoadenosine phosphosulfate reductase family	Bashton M, Bateman A	anon	Pfam-B_590 (release 4.0)	Family	This domain is found in phosphoadenosine phosphosulfate (PAPS) reductase enzymes or PAPS sulfotransferase. PAPS reductase is part of the adenine  nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases [1]. The enzyme uses thioredoxin as an electron  donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) [1,2]. It is also found in NodP nodulation protein P from Rhizobium which has ATP sulfurylase activity (sulfate adenylate transferase) [3].   	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.14	0.71	-4.44	27	7027	2012-10-02 18:00:56	2003-04-07 12:59:11	14	43	3053	30	1986	5609	1987	185.10	24	61.61	CHANGED	phshsaShGp-usVhLcLshKshhs..h....................P.llalDTGacF.Eshcah-cltc+h...sls.lhlhtstcshtpths.hs...phapp........hs.lhKscslpp........................................ALcch..p..AhhsGhRRs-st.sRuphtlhphcss.t.......................hl+lh.PlhsWott-lWpYlhtpslPhssLatpG.....................................apolGCh.sTss	..................................................................................................................t..sh.hS.h.G.t-us....V.hL.c....L....s.t..ch..hhs....h.....................................................s..ll..a.l....D..T......s......h......p.........F...........E.s........h........p.....a.......h.........-...............c.....h.........t...cph..............sh.....p....l....h......s....h....p....s............t......s...h..t.....t..t..h......s.........h........t..................t..h.app......................................................h.h.K..sp.s....hpp........................................................................................................................sl....p.....ph..........t...t..u..h...h..sG...h.RR.--s.......t...s.......R.........u........p.........................h.....h..s..h....c..p..t......tt.....................................h.+.....lh..Pl..h...s...W...o..ptDlWpYl...tp.......p.......sl.............h........ss.La...t.t........................................................a..ho...lGsh.hTt...........................................................................................................................................................	0	598	1228	1656
+3659	PF03285	Paralemmin		Paralemmin	Mifsud W	anon	Pfam-B_4064 (release 6.5)	Family	\N	25.00	25.00	25.40	26.60	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.94	0.70	-4.92	6	266	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	38	0	120	211	0	209.00	26	60.43	CHANGED	h+KQMQEDEtKTRtLEETItRLE+ElEpLEsGsSs.suoKEs.stsu........sPAtpE.p.csl.ssppoPLsTs.ttpchS.oPh+.stussMMpA............................................VVHAV...DGsspNGlpsLSSSEVDELlHKADEVTLuEuutsu...-............sss.s.t+sTP.R+EITGVpA+PtpssstssstpPutEsPVTMlFMGYQNVEDEsETKKVLGlE-.TIKAELVVIEDu-spstsps.....+-pAPPNGSAuEPstsssptEEsphs..ssssssssc....DhshKKQRCKCCoVM	..................................................................................................................................................tp.ppDp.php.LEpsl...R..L..EpE.lp.LEp.t.t.t..hu.spEp..h..t..........................hpc.....c...p............................................................................................................................................................................................................................................................................................................................................................p.PVTMlFMGYQph.-D.pt.Et.pp.hh.uhpt...hlpAElVlIp-ttt....................................................................................................................................................................................................	0	4	21	51
+3660	PF01508	Paramecium_SA		Paramecium surface antigen domain	Bateman A	anon	Bateman A	Domain	This domain is a cysteine rich extracellular repeat found in surface antigens of Paramecium.  The domain contains 8 cysteine residues. 	21.20	21.20	21.60	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.79	0.72	-3.76	78	1822	2009-01-15 18:05:59	2003-04-07 12:59:11	11	40	5	0	1522	1826	0	63.40	27	47.23	CHANGED	ttTcspCpua.ss....CTs.t..........sG......suClsh...ssCssY.sspssCtps.............ssspChWsss........tsChsto.......Cs	....................h..ocspC.psah..ss............Cos..................sG.......suCl..ph....ssCssa...tspp..s..Chts................ssstChWsss............tpChs.ts......Ct..........................	0	1522	1522	1522
+3661	PF03210	Paramyx_P_V_C	Paramyx_P_V;	Paramyxovirus P/V phosphoprotein C-terminal	Mifsud W	anon	Pfam-B_2037 (release 6.5)	Family	Paramyxoviridae P genes are able to generate more than one product, using alternative reading frames and RNA editing. The P gene encodes the structural phosphoprotein P. In addition, it encodes several non-structural proteins present in the infected cell but not in the virus particle. This family includes phosphoprotein P and the non-structural phosphoprotein V from different paramyxoviruses.  Phosphoprotein P is essential for the activity of the RNA polymerase complex which it forms with another subunit, L Pfam:PF00946. Although all the catalytic activities of the polymerase are associated with the L subunit, its function requires specific interactions with phosphoprotein P [2]. The P and V phosphoproteins are amino co-terminal, but diverge at their C-termini. This difference is generated by an RNA-editing mechanism in which one or two non-templated G residues are inserted into P-gene-derived mRNA. In measles virus and Sendai virus, one G residue is inserted and the edited transcript encodes the V protein. In mumps, simian virus type 5 and Newcastle disease virus, two G residues are inserted, and the edited transcript codes for the P protein [2]. Being phosphoproteins, both P and V are rich in serine and threonine residues over their whole lengths. In addition, the V proteins are rich in cysteine residues at the C-termini [3]. This C-terminal region of the P phosphoprotein is likely to be the nucleocapsid-binding domain, and is found to be intrinsically disordered and thus liable to induced folding [5].	25.00	25.00	38.50	64.70	23.40	19.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.64	0.71	-4.35	21	673	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	103	5	0	640	0	161.50	42	37.80	CHANGED	sclcpchcpILsplsol.tlKs-lpsIKs.......olATlEGploolpIh-PGsusss..sssclctssc.pPllssssGcssspltc........................psplthD.Lu+Plsspsppshthssssssho..+..pslpuLIcsphhsscp+pchhphlsps+opp-Ltcl++tIl	.......Klcpp.phllpphsSl.hh+uElpplKp.......SlushEupLu.hhIh.PGhupss..shuDlc..tssc.+PllspssGcs.s...Vhp........................tGplhhshh.pPls+.s.p.hhshs..ss..s..s.shu..+..sslRulIpSp.hc.sppthLhohLDshcuhp-ltKh+ph................................	0	0	0	0
+3662	PF00946	Mononeg_RNA_pol	Paramyx_RNA_pol;	Mononegavirales RNA dependent RNA polymerase 	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_586 (release 3.0)	Family	Members of the Mononegavirales including the Paramyxoviridae, like other non-segmented negative strand RNA viruses, have an RNA-dependent RNA polymerase composed of two subunits, a large protein L and a phosphoprotein P.\	  This is a protein family of the L protein. The L protein confers the RNA polymerase activity on the complex. The P protein acts as a transcription factor [2].	20.60	20.60	24.20	24.20	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	1072	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.82	0.70	-13.58	0.70	-7.19	41	1469	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	433	0	4	1221	0	621.10	23	54.24	CHANGED	EsHLsSPllppclhhhlp.hsshspshthcsps.h.t.hc..hphhtt.psphhtchtph.pshltpplhsh...........ththl.asph...Lh...ph...phspphpphh+hs..spshshhsptlpphhp.....plshpLsspsphtppttt..hp.................phhplt........................................thht.spahp.h.hWh.h...............chph+pllpphpptppppppshlh..hcspshhlllsspllhlhspp.th..hhhhTa-hlLMhsDllpGRhps.hhsshs.......sphssht.pl...........ppLaplsDpl..hthhGsssYsllshlEslshuhL.QLt-.hh.Lp...GpFhsahhsEltp...tLptpshhsptt...hhp.....................lhslhp.phshc.huElauhaRpaGHPhlc....utpAhcKVRcphstsK..llshpshhcstuhFpthlIsGahcc+st.........................tWPssphshpssp.lpphhcssptloh.phslcpacpastlpFppth-hshspDLohahKDKAlSss+p-Whosa.cp.h............h.....psstsstoRRLl.sFLp-ssFsshphlpYVhstpYLpDs-aslSholKE+ElK.sGRhFAKMoa+hRtsQVluEsLlAspluchF+-ssMstsphcLpKpLhphSp.u..................................................................................................................psscshchsushloTDLpKaChsaRaposshauppLsclaGhssLFpWlHhhlpcSslYluDsasPPpsssp.hsL-psss.........sslhhpsshGGIEGhCQKhWTlloIshlhLsAhcsss+ltullQGDNQsIslTpcV......shshppccptshptsppahptL+pshtslGHpLKtpETllSucahlYSKplaacGhlLspuLKshoRsshhosslh-sspuusSsluTshtchtEpGhshhhuahlshhhshpplhh..........pl....................hashssshspslpphhh.....................ps.shlhth...sllPupLGGl.sahshoRlahRslGDPlTsulAclKch...............Ipsshhsppllphlhs.ppPup.....usahcLssDPaSlNlststssTshLKphspcslhps..osNshlpulapcssppE-cpLupFLhspcslhPRsA+tIhspo.sGtpcpIhGhlDoT+Tlhptshpppslssphlpplhphshpphphhhphhpp	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lp.......uh..................................hs.hh..hh..hhpp.t...........................a..................................................hh.h...tt.....t.h...h......h..h.h...h.h....s.p.hhpDKuhs..pp.h.t.h...........................t......sp+l.l..hltp..hs.....p.h..h.p...thh....p...ph.huhp.KE+Elp...GRh....sh..R.h.hhsE.hltp.hh.hh.t.hhh.s..p..c.h...s.........................................................................................................................t.....t.h....hDhpKas.t.Rhp....hhp.hhsphhGh.phaphhH.hh..shhhhs...s.....t.....h.t....p.........t.h.hh.....GGlE.G.hpQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	2	4
+3663	PF01692	Paramyxo_C		Paramyxovirus non-structural protein c	Bashton M, Bateman A	anon	Pfam-B_1202 (release 4.1)	Family	This family consist of the C proteins (C', C, Y1, Y2)  found in Paramyxovirinae; human parainfluenza, and sendai virus. The C proteins effect viral RNA synthesis having both a positive and negative effect during the course of infection [1]. Paramyxovirus have a negative strand ssRNA genome of 15.3kb  form which six mRNAs are transcribed, five of these are monocistronic.\	  The P/C mRNA is polycistronic and has two overlapping open reading  frames P and C, C encodes the nested C proteins C', C, Y1 and Y2 [2].	25.00	25.00	180.00	179.80	22.20	21.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.42	0.71	-4.70	4	36	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	19	0	0	53	0	194.90	70	97.69	CHANGED	M.phlKuhl.LtcRcQEspphophpssoShsSY..SsPTsc+TctsohpSopts+coA...cPolstKscQQ+pt.KIlDQlp+l-SLGcpss.pQ+phlEhLIpKlYptsLGEEhsQhl.LRlWuhEEoPEuspILpMc.chRc.llpMKhERWlRTLlRGKpspL+.FQpRYpEVhPYL.ppKVEpVIMEEAWsLusHllQ-	.M.phl+thl..ttRcpEppphopM.SDS.hpSY.sst.psEcTEAGShssSTh.Kcpuh.hcPplpsKpcpp+RRPKIIDQVRRVESLGEQsSQ+Q+HMLEoLINKlYTGPLGEELVQTLYLRIWAMEETPEShKILQMREDIRDQlL+MKTERWLRTLIRGcKTKL+DFQKRYEEVHPYLMhE+VEQlIMEEAWpLAAHIVQE	0	0	0	0
+3664	PF00973	Paramyxo_ncap	Paramyx_ncap;	Paramyxovirus nucleocapsid protein	Finn RD, Bateman A	anon	Pfam-B_158 (release 3.0)	Family	The nucleocapsid protein is referred to as NP.  NP is is the major structural component of the nucleocapsid. The protein is approx. 58 kDa. 2600 NP molecules go to tightly encapsidate the RNA. NP interacts with several other viral encoded proteins, all of which are involved in controlling replication. {NP-NP, NP-P, NP-(PL), and NP-V}[1,2,3].	21.40	21.40	23.40	23.20	20.60	21.30	hmmbuild  -o /dev/null HMM SEED	524	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.76	0.70	-5.80	9	5874	2012-10-01 19:59:50	2003-04-07 12:59:11	14	1	449	4	0	2227	0	180.70	74	97.00	CHANGED	MAoLLKSLALFKRNKDKPPLAuGSGGAIRGIKHVIIVPIPGDSSIsTRSRLLDRLVRhlGDPDISGPKLTGsLISILSLFVESPGQLIQRITDDPDlSI+LVEVlQS-pSQSGLTFASRGssMDDEADcYFoh--Psuu-ppphtWFEN+EI.DIEVQDPEtFNMlLAoILAQIWILLAKAVTAPDTAADSELRRWlKYTQQRRVlGEFRL-KtWLDsVRNRIAEDLSLRRFMVALILDIKRTPGNKPRIAEMICDIDTYIVEAGLASFILTIKFGIETMYPALGLHEFAGELSTIESLMNLYQQMGEsAPYMVILENSIQNKFSAGuYPLLWSYAMGVGVELENSMGGLNFGRSYFDPAYFRLGQEMVRRSAGKVSSsLAuELGITtEEA+LVSEIAupTs-DRssRuoGPKQuQVSFL+sDpu-stp.psut+--t+shQs+tctppu.+ss+hscsoDppsso.sscThlDlDpspEuspDP.ss++SAEALh+hpAMApILccsshssDoshsYND+DLL	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KVSSTLASELG.ITA.E.D.A....R....LV.S.EI...A....M.H.T..T...ED.R.hSR.A..VGPRQ........AQ..VS.....FL..H..G..DQSEN..EL.P..GLG.G.KE...D...RRV..KQ.SRGEA......RESaRETGs.S.R.ASDARAAHLPTuTPLDIDTASE.uQDPQDSRRSADALLRLQAMAGILEEQGSDTDTPRVYNDRDLL.................................................................................................................................	0	0	0	0
+3665	PF02725	Paramyxo_NS_C		Non-structural protein C	Bashton M, Bateman A	anon	Pfam-B_1636 (release 5.5)	Family	This family consists of the polymerase accessory protein C from members of the paramyxoviridae.	20.60	20.60	20.70	21.80	19.10	20.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.82	0.71	-4.62	6	123	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	31	0	0	111	0	164.30	72	90.13	CHANGED	pPSc.l..shhph++shpuGp+PssppctpcssssR.+coLRISsNHApQQhDQs+oAphhphIRDLE+ulssLh+hsss.cpspcpsLpYsVIMFMITAVKRLRESKMLTlSWFpQAL.llssSpEEpcsLppAMhILAplIP+EhL.LTGDLLPuLppp-.LM	.........................................................G.LSRPSPSAHWPSRKsWQHGQKYQTTQDRoEPPAcKRRQAVRVSANHASQQLDQLKAVHLASAVRDLERAMTTLKhWESPQEISRHQALGYSVIMFMITAVKRLRESKMLTLSWFNQALMVIAPSpEETMNLKTAMWILANLIPRDMLSLTGDLLPSLWGSGLLM.......	0	0	0	0
+3666	PF01806	Paramyxo_P		Paramyxovirinae P phosphoprotein C-terminal region	Bashton M, Bateman A, Coggill P	anon	Pfam-B_1628 (release 4.1), Karlin D	Domain	The subfamily Paramyxovirinae of the family Paramyxoviridae now contains as main genera the Rubulaviruses, avulaviruses, respiroviruses, Henipavirus-es and morbilliviruses.  Protein P is the best characterised, structurally of the replicative complex of N, P and L proteins and consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT [1]. The P protein is an essential part of the viral RNA polymerase complex formed from the P and L proteins [1]. P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional.The C-terminal part of P (PCT) is only functional as an oligomer and forms with L the polymerase complex. PNT is poorly conserved and unstructured in solution while PCT contains the oligomerisation domain (PMD) that folds as a homotetrameric coiled coil (40) containing the L binding region and a C-terminal partially folded domain, PX (residues 474 to 568), identified as the nucleocapsid binding site. Interestingly, PX is also expressed as an independent polypeptide in infected cells. PX has a C-subdomain (residues 516 to 568) that consists of three {alpha}-helices arranged in an antiparallel triple-helical bundle linked to an unfolded flexible N-subdomain (residues 474 to 515).	25.00	25.00	164.00	163.80	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.64	0.70	-5.12	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	20	2	0	49	0	240.10	59	42.99	CHANGED	EESToSs-EMATLLsSLGVIQSApEFELSRDASaVFA+RsLKSANYAEMTFNLCGLlISVEKSp-sKV-EN+sLLKQIQE-lcShRDlHKRFSEYQKEQNSLlMSNLSTLHIITDRGGKTDsP-soTRSPSVFTKuKENKlKKTRFDPSMETLGspKaKPDLIREDEhRDEI+NPVhpEpNs-scASNASRLlPS+EKsTMHSL+LVIENSPLSRsEKpAYIKSLpKCKTDQEVKsVMELFEEDI-SL	..tESsp.hcchhTLLpsLGVIQSspch-..pDtphVhstpsLpsAshAphh..lsGLllusphspssKlsp.pp.lhplppslcphc-.a+Rh.E.QKEQ.SLlhS.lSsL+IhT-RGGKpDps-ossRos.lhsKsKEpKhKtTRFDP.MET.G..K.hPDLhRcsEhpsE.cs.VhpEhsopsctSNAoRLlPp+ppsTM+SLhlVIpsSsLSpupKtuYIppLp+CKoDpEVpplM-hhpEDlpS...	0	0	0	0
+3667	PF01279	Parathyroid		Parathyroid hormone family	Finn RD, Bateman A	anon	Prosite	Family	\N	19.70	19.70	20.90	20.00	19.40	19.30	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.49	0.72	-3.37	11	168	2009-09-12 04:59:12	2003-04-07 12:59:11	12	2	66	21	66	160	0	89.80	41	64.87	CHANGED	pKRSVSctQLMHD+G+sLp-hcRRhWLQcLLc-VHTAphht................................shstsu.p.KPsssTKNlP.tatL.-pEup..sLsQETpKs.saK-....p.hcs.shKKKsKs	........KRuVSEhQLMHD+GKslQshcRphWL+chlp-lHTAphc.................................sss..csussp+Pt..tppcNh................-sc...t+.....Lspt.sKs...............................................................................	0	3	8	27
+3668	PF02195	ParBc		ParB-like nuclease domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.10	0.72	-3.88	51	10329	2012-10-01 20:12:50	2003-04-07 12:59:11	13	78	4621	22	2371	7819	3243	91.10	27	28.42	CHANGED	hplslsplp....sppps+........tpplccLhpoIcp..................pGhh.pPllVcppt.....shapllsGcRRhcAsphhG......hpcl.....ssllhphs........cppththslh-Nh	..........................................................................h..lslsplt.....ss.h.pPRph...........spppl.p-.L.s.pSIcp......................................pG.ll...p.....Pl..lVcptt...........................stYpl..l..s.G.c.R..R.h.+......A.s.p.h.hu.........................hppl.......P..s..l.l.t.phs........cpph.h.t.h.slhcN............................................................	0	734	1530	2000
+3669	PF00644	PARP		Poly(ADP-ribose) polymerase catalytic domain	Bateman A, Griffiths-Jones SR	anon	Bateman A	Family	Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a  carboxyl 40 kDa fragment is still catalytically active [2].	23.90	23.90	23.90	24.00	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.32	0.70	-4.90	28	1951	2012-10-01 23:25:29	2003-04-07 12:59:11	15	267	268	92	1317	1843	56	176.60	20	23.35	CHANGED	Lps.plpsLcpsScEaphlppYhpsTtsss+t.....shplhclF+lpRpuEtccFpttcp.......hcN..............+hLLWHGSRloNasuILspGL+ls.spuPlsGhh.....FGKGlYFADhsScSA..pYshs..sts.......ss.....suh......hlLu-VALG-.h.clhtsp..h..pp...shpSstGhGcstP......tt......ps.....lPtucs.hssthpsst...l..sEYlVYcssQl+h+YLlclph	............................................................................................................h..tp.pat.............l.p.h.p....s.h.t......................thp...l......p....l....c.....l....p...p.......t.........pp..apt.tpp..........................................hs.................................cphLaHG.o...p.h....p.........s..h.................t..u..Il...p...p..Gh....................s..............h..s....s...h.p.....G..t..h............................aGp..G.l.YF..A..s..p...s..o..h.Ss...........p..Ysts......ts................................ps.......th........................................hh..lsc.VhlGp..................................................hh.u....t.............................................................................................................t.alla.p....t...ph..tall.h..h.................................................................................................................	0	534	710	997
+3670	PF02877	PARP_reg		Poly(ADP-ribose) polymerase, regulatory domain	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a  carboxyl 40 kDa fragment is still catalytically active [2].	26.80	26.80	26.90	27.00	25.50	26.70	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.57	0.71	-4.49	35	515	2009-01-15 18:05:59	2003-04-07 12:59:11	9	63	207	33	360	542	8	135.40	33	17.01	CHANGED	cScLstpVQ-LlpLIFDhctMppsMtEhpaDscKhPLGKLSpcpIppGYplL+clpchlp...............tssppstl.c......LSNcFYThIPHsFG...hp+PP..llcotchlKpKlchLEuLp-I-lAspllcsspssc....hssLDppYc	..........................................................spLs.tlpcLlphIash..ch...h...c..psM.h...c.h.................p.hD.h.p....K..hPLG.KLS+ppI.ppGapsL...pclpphlp................................................ts.s.pp.ppl.-...........lSscFYTlIP.H.s..F.G....h.pp.PP.....lIss................ctlp........p.K.l.c.hL.......-sLt.DIElA.pLlpsspp..sp.........cPlDtpYp...............................................	0	142	203	291
+3671	PF01358	PARP_regulatory		Poly A polymerase regulatory subunit	Bateman A	anon	SCOP	Domain	\N	24.00	24.00	24.50	25.00	23.70	23.90	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.90	0.70	-5.77	6	111	2012-10-10 17:06:42	2003-04-07 12:59:11	13	2	69	24	18	112	3	256.90	44	70.01	CHANGED	huhcKP.hhYFcEIssEh-YcsEstsph..pKhPhQGQLKLLlGELaFLs..pLp++shLsu.sslVYIGSAPGsHIpaLh-aapshsl.IKWhLlDGRsHDspLpuLps....Volls+FVDEcYlpph+pt..hph.+llLISDIRSpRG..pEPoTcDLLpDYuLQN.MlSlLKPlASSLKWRCPFPDQW...I+-FYlPcGpEhLQPFAPsaSAEMRLLSlaousshpLpsloppcuhpYEKKMaYLNphlR.+IllsFDYsNQcYDaFaMa+hL+Tlhhs..KoFsosKsKVlalppSIF+hLsI	.........................h.thpcP..hhahp-lstth-Ycscsspp...h.....KKhs..apGQhKLLLuELhFLo......+LpR+..Gh...Ls......u......ssVVYlGSAPGoHIpaL......c.-hF.shs..l+WhLIDsRpHDs.h.LpuLcs......VoLls+Fs.sEp...hl+..pl+cp..hp..tcIlLISDlRStc..s.......ssEP..s.T...tD....L...L.p...sYsLQNhh..lplLpPhAS.LKaRsPFP...DpW.............hccah..lscGschLQsFAPphSuEhRLlslhss.pshp.hppls.p.DshpYE++MaYhNpllR.phl...lsFDYsspp..Y.DaaahahhL....ps.lh.s..p.a..s.ptpll.hppthFp.lt.................................................	0	14	16	18
+3672	PF00740	Parvo_coat		Parvovirus coat protein VP2	Bateman A, Finn RD	anon	Pfam-B_436 (release 2.1) & Pfam-B_445 (release 3.0)	Family	This protein, together with VP1 forms a capsomer. Both of these proteins are formed from the same transcript using alternative splicing.\	\	    As a result, VP1 and VP2 differ only in the N-terminal region of VP1.\	   VP2 is involved in packaging the viral DNA.	19.80	19.80	20.00	20.00	18.20	19.70	hmmbuild  -o /dev/null HMM SEED	529	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-13.16	0.70	-5.55	24	3412	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	190	158	0	2269	0	301.20	29	80.82	CHANGED	G.......suGuGuuGVGsuoGsWcssopapt.....spVospsTRphhLsh.ssc...Ypplp..ssspos.............sssahshsTPWuYhDhNtassaFSPpDWQpLlNshtph+PcuhphcIFNl.lKpVTp....sss.ssshsNsLTuslplhsDssapLPYs.ussppsshs.aPhcsahlsQYuYh.....................sohssssss...p.scc........osFasLEpt.shphLRTGspFph.oYpFp.shPh+psasappshphhhNPlhpphhhthsshsssss.st......hppsptss..httpspNalsG............Pt.....h.ppshpsssusshpsshs....................ts.tthssppsshsst.shspptspssstt......hppphtass.s.puscssp.thspphshscptht.....t..t.p.hh.......hssss.uspos.ph...........sslhshhhhsuulWpscslYhpG.IWsKhPcsDt+h+hp.sthGshshppPPsQlFlKhsPsPss...p..ss.usssShIspYuThphpsclpaclc.+csoppWNP.hQhohss.......s.tshlsas	.................................................................................................tt......G...spu.a.tts.h.........lhsp.oR..hh....tc...Y+.....s...................p..hth.TPWthhshNtht.aFsP.-aQhlhpph.tht..thp.pl.tl.l..Kpl.p.....t.................................................................................................................................................................................................................................................................................................................................................................................................................................ss.pss.ph...............ph.h..stl.s..slh.ps.lWsK..phD.p.hhp.s..s.hs.ppsPsplFlKhh...ss.......t..s.....ohls.Yssh.hpsph.acht..h.totpWpP..p.s.............................................	0	0	0	0
+3673	PF01057	Parvo_NS1		Parvovirus non-structural protein NS1	Finn RD, Bateman A	anon	Pfam-B_400 (release 3.0)	Family	This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA [2]. NS1, is the major non-structural protein.  It is essential for DNA replication.  It is an 83-kDa nuclear phosphoprotein.  It has DNA helicase and ATPase activity [1].  	20.00	18.00	20.00	18.20	19.90	17.90	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.45	0.70	-5.53	24	1228	2012-10-05 12:31:08	2003-04-07 12:59:11	12	11	210	5	11	1432	7	174.20	34	51.93	CHANGED	p......................spspcca..............hsLlchLl........ccGlsoEcpWhths..ppYhphpssssutpplcsuLphsppchssstsshcalsptsss............hshppN+lhplhphpGYsPhhsGphlhsWhs+phGKRNTlWha.........................GPusTGKoplAp...................AIApslPhaGsV..NWsNcNFPFsDsss+hll.WW-EGhhpsphVEssKulLGGpsl+VD.....pKs+sosplpsTPVllTSNs-hshV.hsGsssohtHtps............Lc-RMhphphscplsss....aGhlopp-l+pah.pWupp.........thphshphh	.....................................................................................................................................................................................................................................................................................................................................................................................................hh...........................hlst....h.......h.G..hl....Nh..N.....s..FsF..s...D...st...t.+...ll.haE.E..s..h..h..p...p..s...hV...E..s..uKsILG.Gp.tsRlD......Kt+sS.h..l..sPVlI.o..oNtD..l....h.l.ssGssso..Htts............lppRhh.hph......h..s.....hs.h.....h..hh.........................h.................................................................	1	9	9	10
+3674	PF00989	PAS		PAS fold	Bateman A	anon	Sequences from SMART alignment	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.22	0.71	-10.01	0.71	-4.29	49	15580	2012-10-04 01:10:46	2003-04-07 12:59:11	19	1711	3946	104	4551	43707	3363	102.20	15	16.49	CHANGED	pchptllcs...hssslhshD..tsGtlhhhNsshpplhGhst..pchhGpslhphl.ttp.......hhptltphhtstpptpshphphth..........puphhhhplpssshhstssp...shhshhpDl	.............................................t..hptllps.........hs..s..s..l....l...s....l......-.......pp.....G.......p..........l..........h...h....h..Ns.s....s.p....p....l......h.....G.....h.......st.......p..-........h..........h.......G.......p.......s.........l....h....p.....h.......l.............................................hh...p..h..h....t.......p......h.....h..........t......t......p......................t...........p...h...h.....................................t.......h.....h.........hp..h........h..........................................................................................................................................	0	1473	2845	3740
+3675	PF03793	PASTA		PASTA domain	Yeats C	anon	Yeats C	Domain	This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases [1]. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.77	0.72	-4.32	237	11616	2009-01-15 18:05:59	2003-04-07 12:59:11	14	55	2312	34	2319	8832	1936	62.10	23	21.30	CHANGED	splP.slhG....hshpcApp.hLpp.......tGl........................ssshspGp...VlpQsPss.....Gspl.pp..us.plplhlup	..................tlP..s.l.hG............hshppApp..tLpp.........tGl...........ht..t................ssphs.pGp.......V........l.....p.......Q.....s.P.s.s.........Gsp..l..pp....ss..plplhlu..................................	0	910	1702	2086
+3676	PF00292	PAX		'Paired box' domain	Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.47	0.71	-4.42	6	1629	2012-10-04 14:01:12	2003-04-07 12:59:11	13	23	304	7	623	1527	5	115.90	67	31.76	CHANGED	GpGcVNQLGGVFlNGRPLPNpIRp+IVEhAppGlRPCsISRQLRVSHGCVSKILsRYpETGSIRPGsIGGSKP+.VsTP-V.s+IcEYK+psPuIFuWEIRD+LLp-GVCDppslPSVSSISRlLR	.......................................................putVNQLGGVFVNGRPLPs..sl..Rp+.IVE.LA.+.p.G.l.R.PC.DI..SR.Q...........L................+..............V...............SH............GCVSKILu........R........Y.hETG.S..I..+.P..G.s.I...G.G..S.K.P..............+........V.............A...TP.....c..........VVp+Itp.YKRc..sP..shF....AW..EI...RDRLLs..............-Gl...CspsslP.....S........V......SSIsRllR........................................................	0	161	211	439
+3677	PF03535	Paxillin		Paxillin family	Griffiths-Jones SR	anon	PRINTS	Family	\N	19.20	19.20	19.30	19.50	19.00	19.10	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.48	0.71	-4.50	6	135	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	44	6	60	102	1	163.20	41	33.41	CHANGED	ssPP.V.sPPSu-sLNGo......pWs.usppatsppP..ppsPhh.sStsKs..........SSsssssuEEEHVY........................SFPNKQKSuEsSsssMoSSLGSNLSELDRLLLELNAVQcSsP.uFPu-Ett.uPPLPuusss+Y.l.ENusSsssKsuPPspEKPKRN.uG+slEDVRPSVESLLDELESSVPSPVPsspsup.u-hsuPQcsssSQQ	..........................................................................................................................................tp.s..u.s...s..s..s..t.s...u-c-HlY........................Sh...PsKp...+S...u-Puss.s...h...SSS...LGoNLSELDRLLLELNAVQaNss.....u.........Fss..p...............-t......t...usshPss............Epsss.shpsss....c+.P.ts..sphh--hRPoVEoLLspLEsuVPs..........ss........s...p..t.p........................................................................................	0	4	9	28
+3678	PF03717	PBP_dimer		Penicillin-binding Protein dimerisation domain	Yeats C	anon	Yeats C	Domain	This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.03	0.71	-4.21	165	11499	2009-09-13 02:10:02	2003-04-07 12:59:11	10	19	4376	46	1966	8801	4788	176.10	24	27.45	CHANGED	hl.stRGpIh........DRs......Gph.LAsstsshs.......lhhsspphpptpt......................................................hpcLuplL.t....hs....pclpp...........................................................................................................................................tttpshp.lhltc............................pls.....cphsplpphthp.....................Glthp.sp..pRhYPp..us...hsupllGalst.......................................................t.thG....psGlEpta-phLpGpsGtpp.hps..cstGp.hltphp	...................................................................................................................................................................................................stRGpIh...............DRs......Gps...LA.tstsshs...........l..hh..s.....p..p.ht.p.t.t.p..h..............................................................hppLupll...p......hst.........pplpc........................................................................................................................................................................................................................................................................................................................................................................................t...pt..t.p..p.h..p..hh..hltp...................................................pl.s.....pp.h....t...t....lpp..hthp...........................................Gl.php...sp...pRhY..P..t...Gp......hhupllGassht....................................................................t.ttthG...ppGlEpta.-...........c......h...........Lp....G.p.s.Ghpp..hph....Dph.Gphl...tt........................................................................................................................................................	0	675	1302	1665
+3679	PF01395	PBP_GOBP		PBP/GOBP family	Bateman A	anon	Pfam-B_1765 (release 3.0)	Domain	The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors [1]. This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant binding proteins (GOBP).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.75	0.71	-4.49	158	2289	2009-01-15 18:05:59	2003-04-07 12:59:11	17	9	218	135	802	2480	0	116.50	15	75.34	CHANGED	hhhhh..ht.........hhtphtpph.........pphhppChpc...h.slsp.ctlpphpptphsss.........pphcCahpClhp.p..hshhs....psupl..p..hctlhphhtthhtt........pphpph.....lppCt.......stssss...CcpAap.hhp....Chhpppt	........................................................hhh.....................htthhptChpp...............tlst...p.t...h.p.p.h.t.p.h..p..h.ss..............pphpChhp.Chhp.c..hs.l.hs.........ps.u.p.h......p...hc..p..h.hp.h.htthhtt..........pphtph......hppCt..............ttptps.......tC...p...t.uhp.hhp....Chhp...h...................................................	0	184	287	686
+3680	PF00427	PBS_linker_poly		Phycobilisome Linker polypeptide	Finn RD	anon	Pfam-B_159 (release 1.0)	Family	\N	24.60	24.60	24.90	30.90	22.60	24.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.86	0.71	-4.48	152	614	2009-01-15 18:05:59	2003-04-07 12:59:11	16	8	108	15	206	625	257	129.90	39	46.64	CHANGED	hpsssspschp..plIpAsYR...QlaspphshpspR..hsslE.SpL+sGpIoVR-FlRuLupS-hY+ppFapsssshRhlELsa+HlLGRuPhsppEhtta.plluspGhpuhIDuhl-SsEYtpsFG-csVPY.Rs	...............h....hopsphptlIcAuYR...QVhu..pp..h...h.hp..spR...hsshE.SpLcsGpIoVR-FlRuLApS-hY+cpFapsssshRhlELsa+HlLGRuPhsppEhttahplhus...........pGapAhlDuhlDStEYtcsFG-ssVPY.R.............	0	28	118	181
+3681	PF03792	PBC	PBX;	PBC domain	Finn RD, Mistry J, Burglin T	anon	Pfam-B_3021 (release 7.0)	Family	The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins [1][2]. 	25.00	25.00	26.00	27.40	20.10	23.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.37	0.71	-4.61	8	415	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	103	0	176	302	0	161.20	75	49.67	CHANGED	Shu.....phtpslu-lLQQlhsITDQSLD.EA.QARKHuLNsHRMKsALFsVLCEIKEKTsLShRss.......E--PPDPQllRLDsMLlAEGVuGP.........-cuGstuAsuuusss......ssohEHuDYRAKLuQIRpIYHuELEKY-pACsEFTsHVhNLLREQSRoRPISs+EIERMVsIIpRKFsuIQhQLKQSTCEAVMILRSRFLD	.......................t.........p.hptlhtI.s-psLD.-s..pt+..KasLss.HRMKPALFs.VL.CEIKEKTs.LSIRusQ......EE-PsD..PQLMRLDNMLLAEGVuGP.........EKGGGuA....AAAA..AAAAoG......sssDNSlEHSDYRAKLuQIRQIYHoELEKYE...........QACNEFTTHVMNLLR.EQSRTRPIoPKEIERMVuIIHRKFSoIQMQ....LKQSTCEAVMILRSRFLD..........................	0	32	51	106
+3682	PF02229	PC4		Transcriptional Coactivator p15 (PC4)	Bateman A, Mian N	anon	Pfam-B_6534 (release 5.2)	Domain	p15 has a bipartite structure composed of an amino-terminal  regulatory domain and a carboxy-terminal cryptic DNA-binding  domain [1]. The DNA-binding activity of the carboxy-terminal is disguised by the amino-terminal p15 domain. Activity is  controlled by protein kinases that target the regulatory domain.	20.60	20.60	21.10	20.90	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.70	0.72	-4.74	203	1136	2009-09-14 14:13:59	2003-04-07 12:59:11	11	16	977	22	344	696	66	53.70	41	52.06	CHANGED	sh......hph..utp+clslppapGp.shlDIR-aat..c.s.t..hP..spK.GIoLoh-p......hptLtchl	...................u..spp.GapKclshlSaNGt.sKaDIRpWss...D+s.+..........huK....G..ITLosEE......appLhct.h................	1	134	213	285
+3683	PF01851	PC_rep		Proteasome/cyclosome repeat	Bateman A	anon	[1]	Repeat	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.40	0.73	-7.87	0.73	-3.42	157	1407	2012-10-11 20:00:59	2003-04-07 12:59:11	17	15	352	4	875	1693	10	34.70	28	7.63	CHANGED	uAshulGllttG.sssp...tshphLp..ph.h..sspsshtt	...uAhhuLGLlhtG.ossp..pllphLhsh.hp.pspp.h............	0	256	433	695
+3684	PF01135	PCMT		Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	Finn RD, Bateman A	anon	Prosite	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.23	0.70	-4.80	9	3573	2012-10-10 17:06:42	2003-04-07 12:59:11	14	23	2359	22	1324	13744	3799	199.20	32	79.48	CHANGED	tp.pptLlcpL+ppGhlto-+VhcAMtsl-RpcFlsc.....tsYhDsPhsIGas.....sTISAPHMhAhhhEhLc..LpsGh+lL-lGoGSGYhTAshAphVGppG.....hsluIE+I.cLstpuccNlcp.shp......sVhlhhGDGphGasthAPYDAIaVuAAuPclPpsLlcQLcpGGRLllPVG...stpQhlphh-Kps.Gpl.h+shtsVhaVPLsspct	.....................................................................................p...thl.p.p.h..h..t...t.s...l.p...s.tp..VlpAht......t..l...P..Rc.h.Fl...............s..........t..........s........h...t...........p.....t......A.....Y......p.......s......t......s....l...P..I..u..t.u............................po.I...S..p..P.....h...h.....l......A.....+...M...h...c.....h....L.p..............l..p......s.........s....s.........+....V..L.EIGo.G.S.G.Yps..A....l....L...A...c...l....s........t.....c....s...h..........................ol.E......+.h.p........s.....L.t....t..p.A...+.....p.....p.....L.....c....p....h...s.h.p.......................................N.l.p...h.....t.....h.....G......D........G.....h.......p.........G......a.......s.....s........p.........A.........P...........a.....D......s......I.......l......V........s.......A......A........s.........s..........p..........l........P.........p........s..........L..........h........p........Q........L....p...............GG..h.....L.......V...h.......P...l.........G..........t.........tt............Q.....h.l.h.h.l.p..+.....p..s.............s...ph.....p..l..s..haVPlh....t.........................................................................................................	0	387	810	1083
+3685	PF00705	PCNA_N	PCNA; 	Proliferating cell nuclear antigen, N-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_598 (release 2.1)	Domain	N-terminal and C-terminal domains of PCNA are topologically  identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.	20.30	20.30	20.60	21.70	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.51	0.71	-4.62	13	917	2012-10-02 11:47:48	2003-04-07 12:59:11	13	9	610	146	433	892	363	118.30	32	46.62	CHANGED	MhEARLlQGSlLKKVLEulKDLls-AsFDCSuoGlsLQAMDSSHVuLVuLpLRSEGF-cYRCDRNluMGhNLsSMuKlLKCAGN-DIlTl+A-DsuDTlshlFEsssp-+ls..DaEMKLMDlDsEa	.........................hEsch.pu.slLK+ll-ul..+..-L.lp-..ssa...........-.ss.p.sGlp....lQuMDsSHVuLV..sLhL.pscuFp.c..Y..+..C..D...+.........s.h.sl.GlNls.shsKlLKpus..sc.D..hlp.l..c.t...........c.-.s.s......-..s.l..s..h....h..h..Es.p..pc...+...hs..phchh.hp..............................................	2	146	247	355
+3686	PF02747	PCNA_C		Proliferating cell nuclear antigen, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_598 (release 2.1)	Domain	N-terminal and C-terminal domains of PCNA are topologically  identical.  Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA.	20.60	20.60	20.60	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.51	0.71	-4.22	12	906	2012-10-02 11:47:48	2003-04-07 12:59:11	10	9	585	135	428	908	335	118.50	31	47.57	CHANGED	GIPEpEYsslV+MPSuEFARIC+DLSpIGDsVVISsoK-GVKFSssGDlGsuNIhhpQsosVDK.E-AshIEMsEPVsLTFALRYLNtFTKATPLSspVTlShSu-lPlVVEYKIA-MGal+aYLAPK	.................................................................................IP-...cY..sshlphsSsEFt+Is.+DLpp.h.u..-.....s......l.h..I..ps..s..K.-...u.l..pF..s..sp.G..-.......hG.s.uslhl...p....p.........p......h...-..c.......-.p.......t.....l...plph...p.-.s.Vs...h.oF..ul+YL...ss.F...s.K.A.s.s.L.u.s.pVplph.us.-..h.P.lhlcY.p.......l......t.......s.....h.....G.h.l.paaLAP.........................	0	155	249	354
+3687	PF02429	PCP		Peridinin-chlorophyll A binding protein	Bateman A	anon	Pfam-B_2945 (release 5.4)	Domain	Peridinin-chlorophyll-protein, a water-soluble light-harvesting complex that has a blue-green absorbing carotenoid as its main pigment, is present in most photosynthetic dinoflagellates. These proteins are composed of two similar repeated domains. These domains constitute a scaffold with pseudo-twofold symmetry surrounding a hydrophobic cavity filled by two lipid, eight peridinin, and two chlorophyll a molecules [1].	20.10	20.10	22.20	21.40	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.90	0.71	-4.08	9	449	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	30	13	0	428	1	140.30	71	79.66	CHANGED	Dp.IGcAAKpLSEASYPFlK-IDWhSD....lYlKsLPut.ss.pshcAIDKMIhMGAshDsshLKAAApAHH+AI.GSID.ApGVTShADYsAVNAALGRhlASVPKupsMDVYNuhAsh.hssslsstMFupVNshDApAAhKAFhsFKDVV	......................DcIGsAAKtLuDASYsFhK-lDW.ss....laLp.hPGp.ps.csLKAIDKMI.MGAthDspLLKtAA-AHHKAI.GSIs.spGVTShADa-AVNAALGRlVASVPKQpVMDVYsuhtcI.sDPpVss.MhShVNshDA.pAhpGFhpFKDVV........	0	0	0	0
+3688	PF01884	PcrB		PcrB family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family contains proteins that are related to PcrB Swiss:Q53726. The function of these proteins is unknown.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.59	0.70	-5.11	5	644	2012-10-03 05:58:16	2003-04-07 12:59:11	12	1	623	16	186	1485	1169	227.50	42	96.70	CHANGED	a-llEc+t.lHlTLLDP--ssPEEtlEll...t-uGTDAIMlGGSs..tuVsLDNslRtI+Kl..hsLPIILFPGsssGlSRYADAlFaMSLLNSsNsaWIlG.......ApsLGAtTlpKhs..lEslPMGYlVlEPuss..VGaVG-A+.lPpNKPcIAAhYsluucaLGMRlhYLEAGSGAstsVsEEslclsKsLscssLIVGGGI+SuEpA+chlcuGADlIVTGNllEEssp.lEctl+sltcst	.................................................................................................................................................................................phppW+...HlFKLDP.s...K....p.l....s....D...-.....s...L...-tl...........s.SsTDAlh..lGG..oD.....sVT......DNV...l.+..l..hscl+................caslP..lVLE....lSsl.-u.l...h....P....G....hDh...YalPoVLNSp.cstah.sG.............................hphEAl.K..paG.chhs.....a-Ellh...EGYlVl....Ns-..uK.........VAp.lTcAp.ss.l.s.p-Dlt.AY.Aph.Asc...........hh+l..P..lh.Y.lE.Y.....S..G....s..Y..G...D...l......p...t...V...p...s..l...s...p...p...L.....s.......c.......s....p.......L.....a...Y..G.GGI.pstcpApEMAph..ADTI.VVG....s....l....I....Yc....D.l......cpA.LcTV...ch..........................	0	58	123	158
+3689	PF04194	PDCD2_C		Programmed cell death protein 2, C-terminal putative domain 	Wood V, Finn RD	anon	Pfam-B_19053 (release 7.3);	Domain	\N	30.00	30.00	30.90	30.40	29.60	29.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.31	0.71	-4.65	24	515	2009-01-15 18:05:59	2003-04-07 12:59:11	8	14	299	0	347	505	5	170.90	25	44.09	CHANGED	P.......a.p.a.lss-.Eshp...........shsp.spptplssh-p.tstts...sup....-tc-hhEt......stD+sFp+FpcRlupsPEQlLRY............pasGp..PLhhSpsssssch..........................lPpCs..CGupRlFEhQlhPphlshLcsc...p.s.........uh-WGTlllhsCs+sC.......stsGYh.EEashVQ.-.	..............................................................................................h......h.l.ht.E..................t....p...p..p..tp....h.....t..pp..t.tt..ttt........tt.....................tpp-thEt.........ptD.cs.Fp+Fpp+lu...t.s...P...cQlLRY....................shs..Gp......P.L.hh.osp..s....s.t.p.t............................................lPpCs..CG.upRhFEhQl...hPpllshLchs.....p.s.................................................uh-WG....TllVaTCt..psC...................tst.sah..cEalhlQ........................................	0	120	191	285
+3690	PF04868	PDE6_gamma		Retinal cGMP phosphodiesterase, gamma subunit	Mifsud W	anon	Pfam-B_4858 (release 7.6)	Family	Retinal rod and cone cGMP phosphodiesterases function as the effector enzymes in the vertebrate visual transduction cascade. This family represents the inhibitory gamma subunit [1], which is also expressed outside retinal tissues and has been shown to interact with the G-protein-coupled receptor kinase 2 signalling system to regulate the epidermal growth factor- and thrombin-dependent stimulation of p42/p44 mitogen-activated protein kinase in human embryonic kidney 293 cells [2].	25.00	25.00	67.70	67.60	20.70	18.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.88	0.72	-4.13	5	124	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	56	4	53	95	0	77.10	77	91.72	CHANGED	PPcuT..opusPsAosGPTTP+KGPPKFKQRQTRQFKSKPPKKGVpGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQYGII	.............stsphhusstsstGPsTPRKGPPKFKQRQTRQFKSKPPKKGVpGFGDDIPGMEGLGTDITVICPWEAFsHLELHELAQYGII......................	0	2	6	23
+3691	PF00233	PDEase_I	PDEase; 	3'5'-cyclic nucleotide phosphodiesterase	Finn RD	anon	Prosite	Domain	\N	24.80	24.80	24.90	24.80	24.40	24.70	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.49	0.70	-4.61	8	2707	2012-10-01 20:28:14	2003-04-07 12:59:11	14	49	307	332	1579	2650	61	218.10	32	32.64	CHANGED	YHNhhHAhDVoQosahLLtssulcphho-lElLAhlhAAhhHDlDHsGToNpFplpo..cS-LAlLYssc.SVLENHHluhuh+LLQsEphsIFpNLo++capplhchlh-hlLATDMStHhphhccl+shlpptch............h.hs...c+hpllsLll+AADLSssTKsaplp+RWsthlhtEFFpQGDhEpphGhc..pPMCDRcsA.hlspsQlGFIDaIscPlaplLsDlscc..spslh-tl-sN+	.................................................................YHN....hHAhsVsps......h.............ah.h....l...............................p.................s..........t.................l..................t..............t..h..............h..........s..s..........l....E.h.............h.A.hlhAAhhHDl..D.HsGhsNs....Fhlp.o..................ps..L...A..h..l..Ys......cp....SV.LE..........s..HHh.uhu.h.p.l.L...........p..........p..p..p......h..sI..h..........p.....s..........L...s...............p..c.............p......h............p............p..h.........c..p.........h........l...hphlLAT.D.h..........u.......p..H...h..p..h......l...s..p...h....p....p....h.l.ppt.ph........................................................h..p.........c+h.hl...h.p....h...h.l+.s..uDlSss.................s..+......shc.lpp............p...W...sp...............tlhpEF...ap.Q.................G.D.........hE+..p.h.........s............h....h.............s......P...h...h....D...R............p..............p...s...p................l...s.......p....Q..l.u.FIca.l.s.......hPha..p.t.h..sp.h..h....................................................................................................................................................................	0	624	791	1167
+3692	PF02112	PDEase_II		cAMP phosphodiesterases class-II	Mian N, Bateman A	anon	IPR000396	Family	\N	23.70	23.70	23.70	23.70	23.20	23.60	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.20	0.70	-5.52	5	323	2012-10-02 15:46:01	2003-04-07 12:59:11	10	6	249	0	179	390	31	254.00	25	76.11	CHANGED	Fss..........ssLGQsGGlp-GstouaLlcccusssFlpLDuGollpuls.cLslSKahusshsITlPp.s...h-sushtKsoahlcs+IpsYaIoHuHLDHVuGLVINSPshh.t......p...........................sKKTIaGLsaTIcsLpKHlFNsplWPNLsutGph.h............h.plshh-LsPuEasslTtTThSlls.........................FPlsHuuulhp...hh.....STuFLF+DslS......s-sIlsFGDsEsDpssup.ShptcIWuslAshItpsKLKuIlIECSsPp-oPDspLFGHLoP+aLlpELspLp.......ohssSou.sLssLN...VIloHlKsslAcss......NPccsILtpLcpLsEtssLG.VsIpIsppG	..........................................................................................................ht..ttth.t..h....t.................................hhth-ttsh..h.............................................................................................................h...tshhhhp.ltsahIoHsHLDHlu..G..h..l..l.s.o.st...............................................p..K....l..hu.stTl.pslppthFN.hhWPN...h...ss..st.h.........................................................................................................................................................................h.hpp...s.....................................Sohhhlppp...............................p.hhhFGDsts............Dp....hp....h............p.....t.pplWp..hA.hl.........t..tpL+ulhlEsSa..s.s.s..s.p.p.L.a.G.HLsPphlhtELp.Lt..............................................phs.....t...t........h.....sh......lhl.H.hK...................................................h...t............t..h.h..................................................................................................................	0	41	97	144
+3693	PF00341	PDGF		PDGF/VEGF domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.80	20.80	22.80	21.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.53	0.72	-3.87	57	855	2012-10-02 16:54:34	2003-04-07 12:59:11	12	13	154	99	329	797	0	80.20	36	33.29	CHANGED	CpPR-slV-lhpEasspsst..hap..PsC.VslhRCu...GCCs.c.EulpCsPopspslohplhcl............ttt.spphhhlshtpHspCcC	......................CpsRphlV...-l...hp.Eh.....ss.p..s.st...hFh..PsC.V.lh...RCu...G...CC..s...s...culpChPo..p.spplshplh+l..............................t..hp.p.phsplshtpHppCcC.......................................	0	40	65	165
+3694	PF04692	PDGF_N		Platelet-derived growth factor, N terminal region	Kerrison ND	anon	DOMO:DM04730;	Family	This family consists of the amino terminal regions of platelet-derived  growth factor (PDGF, Pfam:PF00341) A and B chains.	24.90	24.90	24.90	24.90	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.73	0.72	-3.48	10	162	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	44	9	51	136	0	73.90	43	34.82	CHANGED	EEssIPcELIERLu+SEI+SISDLQRLLEIDSV................usEDssppcl+ppps+sspH.....h.-h..+sl.SRRKRS......lEEAVPAl	..........................pts.IPcELhEhLucSpI+SIcDLQRLL......c..hDS.V.................tEDsh-tsLph.ppsHss.pc...............p....Rt+RS..........hE.Al.A.......................................	0	2	6	18
+3695	PF00800	PDT		Prephenate dehydratase	Bateman A	anon	Pfam-B_1095 (release 2.1)	Family	This protein is involved in Phenylalanine biosynthesis. This protein catalyses the decarboxylation of prephenate to phenylpyruvate.	20.60	20.60	20.60	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-11.10	0.71	-4.74	134	4375	2009-01-15 18:05:59	2003-04-07 12:59:11	13	27	4002	7	1176	3130	2645	177.50	33	54.29	CHANGED	luaLGPpGoaScpAAh....phh.......stssphlshsohp...............clhcuVppsc...s.-hullPlENSh..pGsVstohDhL..hp.t..s..................lpIhuEhh...l.lcHsLhstsss............................ph..pc.Icp........lhSHPQAluQCppaLppp....sphp..hhsssSTAtAAch.....t....................pppts.....sAAIuuphAAchY.uL.plltc.sIpDpt.sNhTRFlllucpts	....................................lAaLGPcGoaochAsp..........................phh.........................tph..ph...h..s..hs.s.hp......................................-lhp.sVc...sGp............s.-auVl..P..lE...N..oh....pGu.lspshDhL..hc..s.....s.................................lpIsGE.hh...lsIcas.Lls.t.sss.........................................................ph...pp..Ic..p............la..SHP..............Qu...........luQCppaLppp.........s..p....hc...h.sssSTAtAAch........l..t...........................t.p.s.s..........sAAIus.c.t.uA.p..hY.....GL.p...........lltc..sI..........p-.p.p.p.NhTRFlllucp.s...................................................................................................	0	367	767	1005
+3696	PF03740	PdxJ		Pyridoxal phosphate biosynthesis protein PdxJ	Bateman A	anon	COG0854	Family	Members of this family belong to the PdxJ family that catalyses the condensation of 1-deoxy-d-xylulose-5-phosphate (DXP) and 1-amino-3-oxo-4-(phosphohydroxy)propan-2-one to form pyridoxine 5'-phosphate (PNP). This reaction is involved in de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate [1].	24.50	24.50	25.20	34.70	22.80	24.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.54	0.70	-5.22	9	2100	2012-10-03 05:58:16	2003-04-07 12:59:11	8	4	2052	50	516	1491	2175	235.70	50	96.84	CHANGED	hhLGVNIDHlATLRpARssthP-slcAAhlAtp.AGADtITlHLREDRRHIp-pDlhhlpclhpsc.....hNlEhulo-Ehht.......lALcs+PcpVsLVPE+RpElTTEGGLDlstttp+lcshlccLpssGhcVSLFIDss.cpIcAutpsGAshIELHTGtYAsh+s...................cscptcp.h...hp+lppsAthAt-lGLtVsAGHGLsYpNVpslstI.t..ltELNIGHullucAlahGLtpAVtcMtplhtt	...................h.hLGVNIDHlATLRNAR.........G..s....s.........aPDPVpAAhlAEp.AGADGITlHLREDRRHIpDcDVphL+.p.slpT.+.............hNLEMAlT.-.E.M.ls.................IAlch+....P.chsCLVPEKRpElTTEGGLDV..su....p..t..-+lpsssp+Lps.A..GI.cVSLFID..s..D..t..cQ.....IcAAtc....l..GA..s.hIElHTGsYA.c.A..p.s......................cs..c..p..t..pc.........htRltpuAphA...ts..L....G.......LpVNAGHGLsYcNVpsl..........Aulsp..lpELNIGHuIIu+AlhsGLppAVt-MKplh..h.............	0	150	324	427
+3697	PF00595	PDZ		PDZ domain (Also known as DHR or GLGF)	Bateman A	anon	[1]	Domain	PDZ domains are found in diverse signaling proteins.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.67	0.72	-3.80	58	26099	2012-10-02 11:12:46	2003-04-07 12:59:11	19	730	2536	601	11639	33290	6344	80.30	22	16.19	CHANGED	plpltt...ttttlGhslssssst..............slhlsplhtG..uuAptss.lchGDpIlpl..NG.....pslpsh.sppcshthlcsssp.....plpLtlt	......................................................................................h.....h...tttshGhsltsspst.........................................................sl.h..l.s...p...l........h....tu.....u.....sA.p.....p..s..........G..L.......p...........s............G...Dp.......I..l.......p.........l.........NG..........................hs.l....p...s....h........s........p..p...c..s....l..p..h..l..+..p..stt.......tlpL.l.h.......................................	1	2855	4028	7376
+3698	PF00544	Pec_lyase_C	pec_lyase; 	Pectate lyase	Bateman A	anon	SCOP	Domain	This enzyme forms a right handed beta helix structure. Pectate lyase is an enzyme involved in the maceration and  soft rotting of plant tissue. 	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.59	0.71	-4.85	10	1509	2012-10-02 14:50:22	2003-04-07 12:59:11	14	45	449	44	752	1578	23	190.70	27	45.93	CHANGED	spslVIsustohD..............uhs.hsh..pphhhG...hGussplsNhGhtlh...psoSNVIl+NlpIcsh.......l..t.t....sssspDGDAIplp.Nus.slWIDHsolSsusapss.hs.........aDGLlDIpcuSssVTISNshFssHcKshLhGH.uDst.upDpG.h+lTlsaNhF.sslspRhP.RsRaGhhHlaNN.Y.......sphppYuhGlussuoILSEuNpF	.................................................................................hh...................................................................t.t.......lh.l..s..S.....p..c.Tl...G........hGs..s.s.t...lts...h.....G..ht.lt..............t.s.....s........N.....VIl+..N.lplpsh.....................................................thhs.s..uD..u..lslt.......s.....u.......s.....plWlDHs..s.hs..s.s..........................................tDGl..l....Ds......h..p.....u.o...st.lT..l.S.ps.h....a..............p..............s....+.....s...c...........s..h..L..h..Gp...sc..p......st...D....ps....hp.....lThtaNaa..p..........shsp...........Rh.P...+...h.....R......h....G........h........h...H.......l..hNN.a..............................t..p.h.....h.....a.uh.sss.....t.s.s..p.lhspsNhF..............................................................	0	220	471	647
+3699	PF05041	Pecanex_C		Pecanex protein (C-terminus)	Moxon SJ	anon	Pfam-B_5192 (release 7.7)	Family	This family consists of C terminal region of the pecanex protein homologues. The pecanex protein is a maternal-effect neurogenic gene found in Drosophila [1].	19.80	19.80	25.70	20.80	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-5.32	8	305	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	96	0	180	282	2	209.20	49	13.85	CHANGED	psVcpDc..DSsLVTLCauLslLuRRuLGTASHs.hSsuLEsFLYGLHsLFKGDFRITs.+DEWVFADhDhL++VVAPAVRMSLKL..HQDHFossDEaDE.ssLY-AIssacpphVIuHEuDPuWRsAVLuspPsLLuLRHVhDDGsDEYKlIMLs+RaLoF+VIKlN+ECVRGlWAGQpQELlFLRNRNPERGSIQNs+QsLRNlINSSCDpPlGYPIYVS.......PLTTSas-opsQL	................................................................h.....t...s.ssLlsLshuLslluR.R.u.L.Gs.Auap.....hu........ss.l-sFLaG.LHsLFKGDF....R....Ios.+DEWlF.u.Dh-LLppVVsPulRM.oLKL..HQD.pFsss...-..E.a..-..-s..tsLa-AI........psaEp.....p.....hlIuHEuDP..sWRpAVLusp.PpLLuLRH.l......h.D.-Gs..s..EYKlIMLp+p.aLoF+VIK.......lN+ECVRGLWAGQQQELlFLRNRNPE.RGSIQNsKQsLRNhINSSCDQPl.GY.PIYVS.......PLTTSa.sop.Q............................	1	53	65	112
+3700	PF03211	Pectate_lyase		Pectate lyase	Mifsud W	anon	Pfam-B_2273 (release 6.5)	Family	\N	25.00	25.00	27.90	27.20	19.20	20.30	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.25	0.70	-4.94	12	678	2012-10-02 14:50:22	2003-04-07 12:59:11	8	10	217	9	311	638	4	205.80	33	67.04	CHANGED	ushussssss...tsuuspshpsoIpVttGpsaDG+stpasus.pshussspu-pQcPlFhLEsGAoL+NVllGtstuDGlHCpG....sCsIpNVhapDVsEDAlTlKupu......sspIssuuAhpAsDKVlQhNussolslps...FhAsDaGKLhRosGssphpt.....sslphsssssssshtuls+s.uDssplpssshph.....ssVsptacGsp....usspssc	.....................................sss.........P.....susss..hsl..sps.hhVtsGpsa..D..G..thppastu.....hs..h..u..ss..sp.s.tppcslFhLcsGATLKNlIl..G.....ps...tt-G.lHCcu....sCsl-NVaaccVsE..DAlol..Kupuss...................shplhGGuApsAsDKVhQhNGt.G..s............lpIcs...F.hsp.ca.GK.....lhRSCGsCps....p..........p...............s.........sl.s.s.p..s.h..s.s.ss.....sl.hulNpNhuDpsolpsh.s.lph........tth.p.ptapt.t...........stt.......................................................	0	88	194	287
+3701	PF04191	PEMT		Phospholipid methyltransferase 	Wood V, Finn RD	anon	Pfam-B_14367 (release 7.3);	Family	The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids [1].	21.70	20.30	21.70	20.30	21.60	20.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.21	0.72	-3.93	105	2350	2012-10-01 22:51:20	2003-04-07 12:59:11	8	12	1459	0	1059	3719	1768	101.80	20	45.04	CHANGED	hphhhGhhLhshGhhlshsuhhsLGhtGsahGDaFh..hhp..t.......hlpsusaphhsNPhYhuushshhGhuLh.tssshs.lllshlshlhhhhhlt.hEcPahtclYuppt	...................................................................hh...hhuh.hl.h.hh...u.h...hh..h....h.......u...h.h...t..h...t...h.t...t...s..h..h.s.....s..............ttsp.p.............................LlssGsYp..h.sRpPhY.hu.h.h.l.hh.h.......G...h...s..l........h.....hs....s...h...h.........s.....llh...s.....h......h..h......h...h.h..h.h.hh.hhhh.EE.thl.t.phaut.................................................................	1	349	655	903
+3702	PF03965	Penicillinase_R	Pencillinase_R;	Penicillinase repressor	Finn RD, Bateman A	anon	DOMO_DM03102 & Pfam-B_5099 (release 14.0)	Family	The penicillinase repressor negatively regulates  expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerisation of the  protein [1]. 	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.36	0.71	-3.99	47	2958	2012-10-04 14:01:12	2003-04-07 12:59:11	11	9	1713	20	713	2659	173	112.30	25	82.47	CHANGED	lustEhcVMcllWpput.sosp-lhpt.Lspt.hth..uhoTVtTllsRLhcKGhlspc+p.G+tahYpshlscpphhpttscpllschhts.shsshlsphlcpp..tlotc-lppLpphlpp	......................lopsEhclMc.llW......p......p.....s......p.....h.....osp.-lhpt..L.....p...........c............p....h....p....h..sh..sTltTlls.R.L.h.c.Ksh.lp.....p.....c......+......p.....G....+.....t.....a..h..Yp..s..hls.c.c....ch.h.pt.ts.ps..hlsch.h.s.s...sh...ts.h.ls.phlppp...plo.tc-...lccLcphlp...............................................................	0	301	536	647
+3703	PF00805	Pentapeptide		Pentapeptide repeats (8 copies)	Bateman A	anon	Bateman A	Repeat	These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK [1]. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix [2]. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.50	0.72	-4.66	95	11082	2012-10-03 04:02:01	2003-04-07 12:59:11	17	346	1513	31	3972	17635	5755	38.50	33	30.01	CHANGED	usLpsAsLpsusLpsusLptAsLssAslpsAsLpsuslps	.........................pLttAsLp....s.....AsL.....p......s.....A....sL.....p.s....A.s.L......p.s.A.....s...L.....p......s.A.sLpsupl.......................	0	1098	2769	3557
+3704	PF00354	Pentaxin	pentaxin; 	Pentaxin family	Finn RD	anon	Prosite	Domain	Pentaxins are also known as pentraxins.	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.30	0.71	-4.88	9	1094	2012-10-02 19:29:29	2003-04-07 12:59:11	12	93	109	168	564	1160	95	183.20	29	30.79	CHANGED	KsFVFP+ES-TsYVpLhs.LcKP.LpsFTlCh+hYo-LS..RuaSlFSYuTpp..pDNElLlahc+sspYShhlGss...clhh+s.EphsuPsHlCsSWESuSGIsEFWVsGK..PhV+KuL+KGYTVtspsSIlLGQEQDSaGGsF-toQShVGEIuDlpMWDhVLoPEpIpolYtG.sshs....sNILsWRuLsYElpG.Vhl+P	...................................................................FP...t.st...sas..ltsp.hths...L.puFTlC..hh..h.t.s..shs.......p.h..o..h...F..SY.us...s......p.s...N..-l....l.l............h...t......p.......t......t............s...s...h........p.........l......h...l...ssp.....................t.s..h..h...............h................t........s.....s...p.W...pH.l.C...soW...s.....o...p....s.Gh.hp.....hahD.Gp....................h.s.s...t..p.s..............l.....t..t..u..a....s..l....t...s.......s.G..s...l...l.LG......Q....-Q..D........s..............h....G.........G........s.............F.......-..s............s.....Q.......u...F...lG...-.luplshWDpVLo.sp.pl.....t.s.l..h..ps........p.h.p........GN..ll.sWtshphp.h.s............................................................	1	154	195	378
+3705	PF02896	PEP-utilizers_C		PEP-utilising enzyme, TIM barrel domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.60	19.60	19.60	19.60	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.91	0.70	-5.54	17	9485	2012-10-10 15:06:27	2003-04-07 12:59:11	13	33	4444	34	2008	6852	3404	301.30	34	43.25	CHANGED	+tt.uphtsh.uhssDGp+lclhANlupsp-stsAhssGAEGlGLhRTEalahsp.sp.hPsEcE....................QhpsaculhcAhsG+PVslRTLDlGuD..KtLPa.h.............................chspEhNPhLGaRulRlslsp..s-lhcsQlRAlhRAus...hu........plpIMhPMluohpElcp.s+pllcch+tplctphhth.s.shplGhMlElPuAAhhA-phA+c.sDFFSIGTNDLTQYThAhDRtsst....lual......asPhpPulL+hlppllctAcpcG......hhlGhCGEhuG.DPpul.lLlGlGLDphShSshul.ts+thhtphph	...........................................................................................................t..ht..shs...c.s...p...pl.clh.sNluss.p..-.s...t.s.shp..G....A-GlGLhRTEalahsp....s.....p.....hP.s...cE.............................................................................Qhpsa.p.p.lh.p...u.h......t..s..+....s...V.ll..Rs.h....Dh.su.c......+...Lsh..h................................................................................................t...s.cE..t.NP..hL..GaR..u.lR....ls..l..sp.....s-laphQ.l.RAll.RAus.....ts..................slcIM...lPhlsolcEh.......c..........t...s+.p...l.......l.c..........c.t........t....t.p.l.........t...p...p..............h.....h...p...t.....s.....l...c.lGhMlElPu.sAhhA-p.h..u........c.......c.......s.......D.........F...FS...IGTNDL...T...QashAhDRssst..........lutl.................asshs.P....ull.chlppllcs...A..c....p.pG........................thl.GlC.GEhuG.D.s.p.ss...hLl..s.h.....Gl-plShss.s..s.l.sts+hhltph.h....................................................................................................................	0	656	1260	1670
+3706	PF01327	Pep_deformylase		Polypeptide deformylase	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	\N	22.00	22.00	22.00	22.60	21.30	21.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.89	0.71	-4.83	130	7120	2009-01-15 18:05:59	2003-04-07 12:59:11	16	13	4525	176	1596	4663	3258	154.60	34	87.31	CHANGED	hhpIlphs-s....hL+phupsVp...phs...sp.lppllccM..h-...TMhss.s............GlG.LAAPQlGh..shRlhl....lchsppptt.....................llINPcl.................................................hsp......pthtttEGCLSlP.....s....hhspVpRspplplchhD.hpGpphph.c...hpG.......h.hAcslQHEhDHLsGhLalD+.....lsphcpt	.........................h.hpIlphscs....hL+ph.ucsVs...ths...........sp.lppLlcDM......h-TM..hss..p......................................GlG..LAAsQlGl..spRlll.......lc....ls..p..ppst.......................................lhlNPcI...............................................................t.p.p.......t..p.....s..t.tEGCLSlP..........s..hhu.V.t.Rhpclplch...hD...t.....p............G....pt...hpl..c...scG.......h..hAhslQHEhDHLsGhLFhD+ls..p.t................	0	529	1053	1351
+3707	PF01562	Pep_M12B_propep		Reprolysin family propeptide	Bateman A	anon	Pfam-B_117 (release 4.0)	Family	This region is the propeptide for members of peptidase family M12B.  The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  --amino -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.60	0.71	-4.36	119	2978	2009-09-11 14:07:58	2003-04-07 12:59:11	14	104	182	0	1366	2653	2	126.10	24	15.43	CHANGED	hEllhPp+lp.......................................................hpttt..............ph....splpYplphpGcphhlcLcpscthlussashh...............pYspsGsh.hspps.ht....scCaYpGtlpu.s..s.S..hVul..SsC.uGL+Ghlphp.stsYhIEPl........pts..ssh........pHllY	.................................................................................................................................t..................th....tphpap.l.ps...G.c.ph...hLcL.p.h...s....p.p.l...lu.ts.ashp......................hh.s....p.s....G...pt...hspt.s.................pcCaYpG....p..l.ps.ps.....s....S...........hsu..l..SsC...s...G...L............c........G.hhp.hp...s...ts.YhIE.Pl...........pts......sp.................Hhla...............................	0	218	304	662
+3708	PF03413	PepSY	Pep_M4_propep;	Peptidase propeptide and YPEB domain	Bateman A, Yeats C, Rawlings N	anon	Yeats C	Domain	This region is likely to have an protease inhibitory function (personal obs:C Yeats). This model is likely to miss some members of this family as the separation from signal to noise is not clear. The name is derived from Peptidase & Bacillus subtilis YPEB. 	20.90	15.00	20.90	15.00	20.80	14.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.15	0.72	-3.33	348	4684	2012-10-01 23:09:26	2003-04-07 12:59:11	14	98	1721	4	837	3397	168	65.70	19	24.77	CHANGED	tlo..hppA.hphA.........tpp...............h.......s....st.hhp....hphttt...................................psphsYc.lp.hp............sstt.........hph...lDAtoGcllppp	.....................................................................................lo.cpA.hphA.................hpp.................................h.............s......sp..hhp........hp.tpp............................................................psphsYp..lp..lp...................sstp............hchh....lDAp.oGcllp........................	2	290	543	701
+3709	PF00311	PEPcase		Phosphoenolpyruvate carboxylase	Finn RD, Coggill P	anon	Prosite	Family	\N	20.60	20.60	20.80	20.60	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	794	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.50	0.70	-13.20	0.70	-6.70	65	4128	2012-10-10 15:06:27	2003-04-07 12:59:11	12	6	3076	5	773	3411	2728	540.50	36	85.56	CHANGED	pLslcLVhTAHPTElsR+ollpKp++IuphLppL-p.phsspcc.................pplcppLpccIphhW+TDElRph+PTVlDElchuLpYFcpsLaculPplhcclppsL....pppasthphPh..........shhpFGSWlGGDRDGNPsVTs-lThcshphQRphslchYlpslcpLhppLShS..hspsss-Lhpplcpcpt..............phschh.ph.t.h..pEPYRltLuhlppRLtsTpcc.pphhssp......................hsssphYpssp-hhp-LpllpcSLppsu.t.lusspLtcLlppVcsFGhpLspLDIRQESs+Hs-slsElscaLsl.....stsYsphsEp-+htaLhpELps+RP.L.....lPs.......ph.....shSccTpEslssh+sltclppcaGscshpoYlISMscssSDlLpVlLL...t+EuGLhpssss.............spLtVVPLFETl-DLcpAPplMppLhslPhYRphlss..............................shQEVMLGYSDSNKDuGhloSsWpla+AQcsLtclAcca....GVpL+LFHGRGGoVGRGGGPu.apAILAQPsuol.sGpI+lTEQGEVlusKYuhP-lAhtsLEhhssAllpAS..Llsss.sp.......ppWpplM-cLuspSpppYRsLVaEpP-FlsaFppsTPlpElupLsIGSRPA+R....+s..stslpuLRAIPWVFuWTQoRhhLPuWaGlGoALpphh...tpssp.....plphLcpMYpcWPFF+shISplEMsLAKsDLpIAppYsppLs.ssc.tct...lappIppEaphTpchlLplTsppcLLsssPs............LpcSlpLRNsYlsPLsaLQVpLL+RhRptspp.............................pphscs-hLcsAL.LTINGIAAGMRNTG	............................................................................................................hhTAHPTp....sh.........h.....h.........................................................h.....h...h.o........ps.sEhp.sh.hhppshhpslPphhpchp....p..h.....t..t......h..........................lp..hstWhGGDRDGN.P.VTsphht.sh.htt.hh...h...h..h...hs................................................................................................................................................................................................................................th...l..h.t....l.........................h..hh...h..FGh.h..hDhRp...puthattsls.t.l.h....t........h.....th................tpY.tt..hsEtp+.t.h.Lhp...p.L..t.t...R.....L........s.................h..............s.....t........h..t.c..Lthhphh...tth.......tshtthlIShspssSDl.Lt.l......lL.......+.Esth.................................................h.lsPLFEpltDLp.tu.thhtphhshshhpth.l.ts.......................................................hQ..lMlGYSDSsKDuGhhuusWt....YpApptLh....p....h....s....c....p....h.................u...lclphFHGRGGo......lGRGGu...P.s...a....A.l....huQP.......to..l...p.u.tlRl....T.....QGEh.It.p..au....p....hshpsLphhsu.A.h.Lpts...hh........t...sp..................................................pap.t.hM-phu.h.u.h..p.YRsh...Vh.......p.p........p..F...h....YFh.....................tuTP..Ehup.h.s.lGSRPupR.....ps......ts..s....lpsL.RAIPWlFuWoQsRhhlP..sWhGh..Gsuhpth.........p.t..........................p.t.LptM...........hppWPFFpshls.l-MVhuKss..lAth.Ysphh...st.p.h........hhptlhtp.hp.shphlLt..lt.sp.p.p.lhtt.sh..............l.t.pplphR..Yh..ssLshhQ.h.h...lt+.Rt.t................................................thl.hohtGlAs........................................................................................................................................................................................	0	201	483	654
+3710	PF00821	PEPCK		Phosphoenolpyruvate carboxykinase	Bateman A	anon	Pfam-B_1309 (release 2.1)	Family	Catalyses the formation of phosphoenolpyruvate by decarboxylation of  oxaloacetate.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	587	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.87	0.70	-6.35	56	2517	2012-10-02 15:24:17	2003-04-07 12:59:11	13	4	1840	45	434	2002	389	325.30	56	96.18	CHANGED	palp-sscLspP-plalCDGS-cEhcpltpphlcsGphhhLt.p+a.NsaLsRocPpDVARVEs+TFIsopscc-ssPssN............WhsPp-hcppl.pplasGsM+GRTMYVlPFSMGPluSPho+l..GVplTDSsYVVhSM+IMTRhGpplL.....ctL.ssctpFV+slHSVGtPh..s....ptsss.WPCNs.ccphIsHhP--+......pIhSaGSGYGGNuLLGKKCaALRIASshA+...-EG.WLAEHMLIlGlTsPp..GccpYlAAAFPSACGKTNLAMltPsl....sGWKlcsVGDDIAWh+hs.p-GpL.....hAlNPEsGFFGVAPGTu.cTNPsAMpol..tp.NoIFTNVAhTsDG.cVaWEGhspp..Ps...........plhsWpG.......cs.Wp.s....pssc.PA...AHPNSRFTsPhsQCPhlc.PcW-sPcGVPIsAIlFGGRRssslPLVhEAhsWpHGVa.lGAohpSEsTAA.Apupsuhlc+DPhAMLPFhGYNhGcYhpHWLshupc.........p+hP+IFpVNWFR+sp.sG+FLWPGFGENtRV.LcWlhcRlcG....c.ssAhcTPIGhlPphssLslpGL.thspt....s...hcclholststWhpEl.cplcc.aapph.GscLPpplhpcLctlcpRlpph	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sap.hpslGDDI.sWh+...s..tp.....G..pL.....hAINPE.sGFFGVA..PGTshpTNPsA........MpTl........hpN....T.......lFTNVAt.T.s.....DG.sV.a.WEGh-c-h...ss............plTDWhG.ps.Ws..................cstp...PAAHPNSRFss..PApQCPhID.Pt.W.EsPpGVPI..sAIlFGGRRs..p....sVPLVhEAhsWpHGVa.lGAsht......S..........Es....T.AA...A.............t...tp....t..............lh+DPhAMhPFhGYphupYh....................................................................................................................................................................................................................................................	0	144	249	359
+3711	PF01293	PEPCK_ATP		Phosphoenolpyruvate carboxykinase	Finn RD, Bateman A	anon	Prosite	Family	\N	25.50	25.50	25.80	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.40	0.70	-5.97	128	2905	2012-10-02 15:24:17	2003-04-07 12:59:11	15	5	2608	26	690	2097	1598	442.70	48	86.52	CHANGED	sssplhh.NlssspLhEculp........cs.....EGhlsssGALslpTGpaTGRSP+DKFIVc-ssoccplaW......GslNpPhst-pFctLhp+shsaLss+.claVhDsauGADsca.RlslRVlsEhAWpuLFs..+NhFIRP....sp-ELp.sF..cP-aTllsuPsFpAcPtpc.GspS-shlhlNasc+hhLIuGTpYAGEMKKulFol.hNYlLPt.+slLsMHCSANlGp.c..G.Ds......AlFFGLSGTGKTTLSA......DPpR.pLIGDDEHGWs.-sGVFNhEGGCYAKsIsLSpEsEP-IasAI+..FGulLENVVl.ctps+plDasDsSlTENTRsuYPlcaIsNthhss.huGcPcsIIFLTsDAFGVLPPlS+LTs-.QAMYHFLSGYTAKVAGTEtGl.oE.PpsTFSsCFGAPFhPh+PshYAchLsc+l.......pc.asspsaLVNTGWoGGs...YGs..GpRhslchTRAllsAhLsGsL....sssc..acppshFslplPpsls.....GVsspl	..................................................................................................................................ts..plhaN.Shs.Lapctlp.......s................cGhlT.ph...GAlsspT.G.haTGRSPKDKalVc-..s....soc-....plaW.........t..ssNpPhstEsa.ppLhthshc.LssK..claVhDuas..Gu.s.cpR.lplR.h.ls.EhA.Wp..u.hF.s.....+.N.M.F....IR.P............o.p...-.E.......Lt......s.F..........c.......P.D.Fslh..N...u.sp....h........p..s...s.....h..p-...G.h...s........S..E.....shl.hhNhs....c+....h.lIuG.T....Y..u..GE.MKKGhFSh.MNYlLPh..cslhSMHCSAN....s....Gc....c......G...DV...........Al..FFGLSG..TGKT.T.LSs......................DPc..R.....pL.IGDDEHG.Ws....Ds..GV..F..NhE.G.G....CYAKsIs..LS.p.E..t..E.P.-..Ia..s.AI+..hsu.lLE.NV.......sl..c.pst..plDa.sD.s.Sh.T.............E..NTRsuYPI.aIs.....Nhs.....h.....Ps....tuu....Hs.p.p..........lIF..LTADA..FGVLPPlS+L.o.s-.QshYHFLSGaT..A..K............lAGTE.+.......Gl....TE..P.ps.......TFSsCFG....AsFls.LHPopYAchLsc+.h.......pt..t.sspsYLVNT.GWsGs.....................GKRhsl+.TRullsAIlsGsl.......p.pu-......htphs..hFsLtlPsplsGVssp.......................................................	0	226	436	591
+3712	PF01195	Pept_tRNA_hydro		Peptidyl-tRNA hydrolase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	21.70	20.70	19.70	20.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.20	0.71	-4.80	116	4825	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	4548	28	1217	3288	2684	180.00	38	92.48	CHANGED	LlVGLGNPGtcYppTRHNlGFhslDpLsc......chs......hphppppthpuhhsp.h...ht..............sp...cllLlKPp.TaMNhSGpuVttlhpaYc.....lps.ccllVlaD-lDLshGpl+l+tsGusG.GHNGl+SIhppLGo.pcFhRlRlGIG...+...P.....ttt...slssaVLupFstpEtptlpp.slppuscslpthlpp...s....hstshsph.s	...............................LIVGLGNP...GscYttTRHNs........GF...hhlDt.LAc...chs.........hshpp.p......p.........Fpu..h.huc...ht...ls.....................................Gc..clhLl+Pp.T....aMNhSG.cu..V.t...s.l......h....s....a..Y.c...................lss....-....-.......l..lV.l..aD-LDLssGplRl............+.t.......sG...us.........G....GHNG..............l.K.S.....I.hs.p.........L................G..............s.....p............s...............F.....h.........Rl..RlGIG....+.Ps....spt...................pVssaVLucF...s.p.p....E..pt.h.lsp...sl-c.uscsl.phhlpp..s..hppshschp............................................................	0	407	789	1024
+3713	PF03564	DUF1759	Peptidase_A16; Peptidase_A16_N; 	Protein of unknown function (DUF1759)	Griffiths-Jones SR	anon	MEROPS	Family	This is a family of proteins of unknown function. Most of the members are gag-polyproteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.76	0.71	-4.39	8	975	2012-10-02 13:37:57	2003-04-07 12:59:11	10	76	48	0	921	926	2	119.20	20	16.10	CHANGED	FuG-hpEWpsFh-lFpShlHsppcLucl.KFpYL+ShLpG-AAsllpHhsl.TusNYpsAh-tLpcRY-NscpIhpsLhcclhcl.s.sspcssptL+plh-ssscllRtLcplGcps-..DshlspllLpKlspcs+++hlppu+cpcs	............................................FsG.p..h..p.a.tFhp.Fp.shlc.p.tp.ls.s.hp.Khth.L......h..phL....p.G..p.Atphl.p...s.h....h.....ss..t...s..Ypts...hp..hL.pppas.p...p.h...lh.pthhppl.p.h....................ts....tthpt...h...htthpth..h...t..l..pt..h..t.....t......t..........h.........h..ph................tt...................................................	0	563	601	892
+3714	PF03566	Peptidase_A21		Peptidase family A21	Griffiths-Jones SR	anon	MEROPS	Family	\N	25.00	25.00	46.00	25.00	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	648	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-13.09	0.70	-6.43	5	29	2012-10-04 01:49:40	2003-04-07 12:59:11	8	1	9	20	0	36	0	607.00	68	93.74	CHANGED	uDANlAupp..sR+RoRslR..............................................pNP..............ltApsVsVuss+RpRR+RRsG++hss.ssspsAstcluQsLsusolossushooM.PslRshAttclDlussSlGWaaKYLDPAGAsESu+AlGEYSKIPDGLl+aSVDAEhREIastECPsVo-solPLDGupWoLSIISaPhFRTsalAlANlsNc..ElSL-slN-lIpsLNN.luDWRD.lsosQWspFopsssaYhpIhVLpPTYAhhDVPDPT-.GlstoVoDYRLTYKGITsEuNsPTLVDQGaWVGAQaslsPsoEsQpslsc..uGosslusoshhpssuusshthsWA..sLPsGGoAPssssuhT.soSGpFhshchsG.s..uuVhoaTlPpGathEs........ssFAssGDTlTFsh....suGsslslTp......TAPTsTlTlhuohTuossl..sRslss-oG.....hss.l-ssulNRp...plslPPhThuQsssNsPKhEQFLlKETtGsYlVHpKMpNPVFpMTPASSFGuVpFssPGa-hssstsulGGIRDThDsNaSoAVsHFpSLSpSCoIVsKTYpGWEGVTNsNSPaGQFAHoGs.K-DElLsLAccLsscLTGVYPAsDNFAGAVSAhAAshLuplsKSpATuSlIKuVApsAsGslpuuhApLsGllpSl.G+luAR....l+ARRARRRAuRts	...........MDSNSAS....GKRRSRNVR...............................................................IAANTV..NVAPKQRQARGRRAtSRANNIDNVTAAAQELGQSLDANVITFPTNVATM.PEFRSWARGKLDIDQDSIGWYFKYLDPAGATESARAVGEYSKIPDGLVKFSVDAEIREIYNEECPTVSDASIPLDGAQWSLSIISYPMFRTAYFAVANVDNK..EISLDVTNDLIVWLNN.LASWRDVVDSGQWFsFSDDPTWFVRIRVLHPTY...DLPDPTE.GLLRTVSDYRLTYKSITCEANMPTLVDQGFWIGGHYALTPIATTQNAVE....GSGFVHPFNVTRPGIAAGVTLTWA..SMPPGGSAPSGDPAWIPDSTTQF.QWRHGGFDAPTGVITYTIPRGYTMQYFDTTTNEWNGFANPsDVVTFGQT.GGAAGTNATITI......TAPTVTLTILATTTSAANVINFRNLDAET............TAASNRS...EVPLPPLTFGQTAPNNPKIEQTLVKDTLGSYLVHSKMRNPVFQLTPASSFGAISFTNPGFDRNLDLPGFGGIRDSLDVNMSTAVCHFRSLSKSCSIVTKTYQGWEGVTNVNTPFGQFAHSGLLKNDEILCLADDLATRLTGVYGATDNFAAAVSAFAANMLTSVLKSEATTSVIKELGNQATGLANQGLARLPGLLASIPGKIAAR....VRARRDRRRAARMN.............	0	0	0	0
+3715	PF02160	Peptidase_A3		Cauliflower mosaic virus peptidase (A3)	Mian N, Bateman A	anon	IPR000588	Family	\N	21.30	21.30	21.40	21.50	20.70	21.10	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.39	0.71	-4.72	6	102	2012-10-02 15:32:34	2003-04-07 12:59:11	10	11	42	0	23	125	0	173.90	29	22.75	CHANGED	NPNSIYIKGpLhF+GYps.hplchYVDTGASLChAs+alIPEEaWpsuc+PIpl+IANsplIpIsKVspsl.lpluGcpFhIPTlYQQ-oGlDlllGNNFC+LYpPFIQapDpItF+hsp..psV.hpplT+AhhsuspuFLEShKKpSpspp..shNIopsp.....-plshlp.hc....-E+hapth..+hptIEpLLEp.VsSEpP	......................................ht.h.hpshlDTGAslChhpc.hlIPcchW.psppsl.hlphAssphhplshhspplplhIs.s.....chFpIP.plY.....pp...-.....o....s..hDhllGsNFhp.LYpPF.lph.p.-.p.lhFph..st......l.hhttlsps.....hphshpth....hps..hpptpp..spp....shp.....th......................................................................................................................................	0	1	17	19
+3716	PF01828	Peptidase_A4		Peptidase A4 family	Bateman A	anon	MEROPS	Family	\N	21.00	21.00	21.00	22.50	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.49	0.70	-5.27	22	234	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	99	7	175	241	1	194.70	32	70.59	CHANGED	SoNWAGAVL.....sussYTuVoupFsVPpPosssus.................st.suSAWVGIDGD.ThssA...ILQsGVDFhlp..sGpsoaDAWYEWYP-hAYsFsslslSsGDsItlsVsAoS.osGsAhlENhooGpoVo+Tlou...ousLsthNAEWIVEDFppuso......hVshAsFG.oVsFTGApAss.uGpohGhssATll-lc.Qs..spVLTcsolsusotloVpYl	..................SsNWuG.ulh...........sussaosVousasVPssosss.u.............................s.uSuWVGID..G......s....ssssu...............lLQsGl..shp.............h.....p.........sG..p..ss...........asAW.............a..EWa.......P...s..h..u...h.....s..h...s.....s..hs.lssGDplpsoV.s..s..so...s.o.....s..G..s....ssl.p.N.......ho........sG....ps....sopo..hos.........sssL..sttsAEWIVE....D....h...p....t....s..s.s.......hs..sh.AsFG.sVsFos........spAss......sutp..h.....s...ss....u...p....h..hph.....t..tt..s.s..........................................................................	1	28	100	140
+3717	PF01829	Peptidase_A6		Peptidase A6 family	Bateman A	anon	MEROPS	Family	\N	25.00	25.00	324.40	324.20	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.33	0.70	-5.43	3	9	2012-10-04 01:49:40	2003-04-07 12:59:11	11	1	7	40	0	24	0	359.20	60	88.70	CHANGED	AhspNNLh+LSpPGLuFLKCAFASPDFNTDPGKGIPD+FEGKVLo+KcVLTQS.INFT....sN+DTaILVAPTPGVAaW....sAcAPAssuAloTTssFsAVsFPGFsSLFGToATsRADQVoAFRYASMNsGlYPTSNLMQFAGSIoVWKsPVK..LSosQaPVATTPsT..SQLVHAIsGLEulLAVGs-NYSESFI-GVFSQSVCNEPEFEFaPILEGlQTLPPANVTVAQAGMPFNLsAGAtsVAGaTGlGsMDAIsI+VTAPTGAVNTAlLKTWAClEYRPNPNosLYcFAHDSPAsDElALQpYRKVARSLPVAVtAKpNAoMWERVKSILKSGLshASsVPGPVGlAATGlpGIu-LIuuLuF	.......s.hNhsALsRLSpPGLAFLKCAFAPPDFNTDPGKGIPD+FEGKVloRKDVLsQS.IoFs....uspDTaILlAPTPGVAYW....sAsscAushshoTT.sFsuVsYPGFTShFGTTATS...RSDQVSSFRYASMNsGlYPTSNLMQFuGSIoVWKsPlK..LSosQaPVuT..sPAT...SsLV.HsLsGL-GVLAV.GsDNaSESFIKGVFSQSsCNEPDFEFsDILEGlQTLPPsNVslusoGQPFsLsAGuEssoGlsGaGNMDTIVI+VSAPTGAVNoAILKsWuCIEYRPNPNAhLYQFuHDSPPhDElALQEYRsVARSLPVAVhAAQNAoMWERVKuIlKSuLusASsIPGPlGlAASGIpGLSsLhpuhuF....	0	0	0	0
+3718	PF01252	Peptidase_A8	SPASE_II; 	Signal peptidase (SPase) II	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.30	28.10	23.20	24.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.22	0.71	-4.60	181	4771	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	4358	0	1061	3181	2288	151.40	31	88.98	CHANGED	hlsh..hl....lh.lDQhoKhhlhpph.................h..................psh....hlss...h.hslshlp..NpGsAFuhhsst......h.hhhhlslllhhhlhhh.hh+htp.......tthttlu.l....uLllGGAlG.N.llDRl.........hh...........................Gt......VlDFls.h......h.................hta.P..sFNlADsuIslGslll....llth.hh......tt.ppp	.....................................................................................hhlslll....ll.lDQhoK..hhlh.ppht.......................hs....................psh..........ll..s..s....h....hslshsp..NpG.....AA.F...S.....hLsst.............ph...hFh.hlslsls.l.h.lh...hh...hh.+p..tp......................pth..htlu..h.....uLl..lGGAl.GN.llDRl...........hp............................................Ga.VVDalph......h...........................hp.a..s.....lFNlADssIs...lGshllllth.hh.......pptt.......................	0	371	723	907
+3719	PF01640	Peptidase_C10		Peptidase C10 family	Bateman A	anon	Pfam-B_1522 (release 4.1)	Domain	This family represents just the active peptide part of these proteins. Residues 1-120 are not part of the model as they form the pro-peptide, which before cleavage blocks the active site from the substrate.  The catalytic residues of histidine and cysteine are brought close together at the active site by the folding of the active peptide.	21.80	21.80	21.80	22.00	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.78	0.71	-11.58	0.71	-4.53	53	317	2012-10-10 12:56:15	2003-04-07 12:59:11	12	11	122	17	47	318	19	176.30	29	29.83	CHANGED	WsQssPYNphsP..............stpssTGCVATAhAQlMpYacaPpp......uhGsh.sYpsstsp.........hphsh.....sposYsWssMhsshsp.........shspppt.cAVApLMtclGhAVpMpYsss...uSG.uhstp.shpALpphFsYsts.lphh...+sthssspWtshlhpELss..utPVhYsGsstss.....GHAFVhDGY....................scsuha...HhNWGWuGt.usGYap	..........................................................................WsQttPYN....t....hsP...................ttpshsGCVATAhAQlMta....ap..a....Ptp....t.tt...sht.t..t..........................ttt..asWsp...h...sshp...............sptpt..pslupLhtclG..hu..l..pM..pYs.s.........uSu..u...tt....s.ps.....Lpp........a.sYs.....ts..ht.h....+p.hs....t..pp....a....phl.h.p-Lpp...s..p..P...Vh.hs..Gsstss..................GHAaVhDGa............................................................................s.pps...hh........HhNaGWsG...ss.Gaa.................	0	18	39	47
+3720	PF03415	Peptidase_C11		Clostripain family	Bateman A	anon	MEROPS	Family	\N	25.80	25.80	26.00	29.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.47	0.70	-5.49	7	367	2012-10-03 02:24:44	2003-04-07 12:59:11	9	25	244	4	90	357	28	328.40	17	58.43	CHANGED	VahsuDN..sLptah.pDlpEMhpu.pss.....sllllhDth.....................hppsphh+lsccsph..ttl.sssth-hN.GDsssLcsalphhpspa-ADphhLlhWsHGsuah.csp...h.s+ulsaD-sN......tsplthsElpcsLp.....ts.plDlLuFDACLMGohEVhYplRs.....pADYlVASu...PG.GacY.phls.l..ssssss.....................plut.hV-pYt-.hssshh.........shoLSlaDhScl-tlhpslctlApsh................ss..pp.............shhsh......................................as.hspt.hsphsYpsLh-Lsphhpt.pphssthtth.ts...............................................................h....pshpphllYu..aG-hsst....shppuh...........oIaLPpssp..............shptahssasslt.....a.tchtWsc................l-pW	................................................................................ah.uss......sh..t...t.h...t..sltphh.t..s..htt.........t............plllhhst..........................................................t...thh.....h...p.t.t.t...h.........tth...hp...........p...s....s...s.s...ps....lpphlp....shp....a....PA.......c...p......YsLllhsHG............sGW..........h.....................s+..u.....h..s..hDpp.p......................................tt.t.hs..l..s.-lspulp.................sshph-hlhFDuChMuslEVAYpL+s......hscYllAS.s.sph.......u.......Ghs..Yp..p.hhstl..........s.s..ss..s..ht...........................................p.h..u.pthh.s.Y..t.s..h.s.sh.................................tho..l.olhDhsp.l....c.s.lt....phhcp.l.h..th.....................................................................................................................................................................................................................................................................................................................................................................................................htt.h........................................................................................................................................................................................................................	0	51	78	88
+3721	PF01088	Peptidase_C12	UCH; 	Ubiquitin carboxyl-terminal hydrolase, family 1	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.80	20.80	21.00	21.00	19.10	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.62	0.70	-5.16	72	1199	2012-10-10 12:56:15	2003-04-07 12:59:11	16	18	337	29	757	1143	15	189.70	30	64.44	CHANGED	sWhslESsP..sVhsphlppLGV..pshphp-lauL.Ds.....Lthl.pPlhullhLF.h.........hptppsttht...........tpt.sptlaFh+Q..sIsNACGThAllpslhN..sts.........lp.GstLspahchstsh.sP.ppRuphLpss....ctlcpsHsuhA.....ppu...........pspsst......pcs......saHFluaVs.....hsGpLYELD..Gh+p.tPls+Gtss.......scsalpcst...llp.chhp+h	................................ah.lEusP..tlhs.....ph....l.pphGl...pshphp...-lauL..-t..............p..lt.....l.......................pPlhul.....lhLF.ht.............................tt.........tt..t..p....tt....................h.......p..t..spslaFh+.Q..sIsNACuT......hA..............llpslhN........spt.......................l..p...G.s.tLpph.h..c......s..t..s..h....s.s.t.+uhhlp.ss...........p.tl...cp....sHsshA...ptt...............................................ppps...........cpcs...........saHFlual..............hsGpLaEL...............D..Gh......+....tP..ls.h..Gs.hs........pcshl.ptst....lhp.phh................................................................	0	230	382	594
+3722	PF01470	Peptidase_C15		Pyroglutamyl peptidase	Bateman A	anon	[1]	Domain	\N	22.70	22.70	22.70	22.70	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.15	0.71	-4.48	9	2041	2012-10-01 19:48:29	2003-04-07 12:59:11	12	13	1648	60	470	1259	104	185.10	39	88.92	CHANGED	hKlLlTGF-PFGs-slNPoh-ss+pLst.ppIusAplhuchlPssFpcut-sLpcslpch+PDlVIslG.AsGRotITsERVAlNlsDA.R..IPDN-GpQPlDcsIpsDGPsAYFoTLPlKAMspsl+csGlPAslSpoAGTaVCNalhYtshah.sppu.sl+uGFIHlPalP-QVlsK.tp.....PSMsL-s.ltGlpsAIcsuhct.	...................................................clLlT.G.Fs.PF.u.s.............c........p....l.....NPu........h....E..s....l...c...t.L.............s...................p...............p.......I...............s.............s........s.............p.........l.......h.....t..h.....pl......P............s..s.......F......t.c.u....h.........p.......h...l....p...p....t...l....p.......p.......h.......p.......P....D...........h...V...l...slGQA.G.G.Rs.s...l.TsE....R....VA...I....N....h..s..DA....R.......Is.D......Np......G...p.Q.P.l.Dp..s..I...h......-..G........s...s....A........Y..F........o.sLP........l..KA....hl...p..........sl.....p..............p..........p..........G....l..P.......u...........s..........l.............S..poAGT..aVCNalhYthh..a...h....h......p...p.........p.....h.........t....h.+.....uG....FlHlP.....a.hs.-.Q.s.h.s.+.s.s.t..........suMslpplhtul.phultsh...p....................................................................................	0	141	256	365
+3723	PF01831	Peptidase_C16		Peptidase C16 family	Bateman A	anon	MEROPS	Family	\N	20.20	20.20	20.40	20.20	16.80	19.10	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.58	0.70	-4.85	2	113	2012-10-10 12:56:15	2003-04-07 12:59:11	12	9	56	0	0	122	0	244.20	70	4.43	CHANGED	AFDAlhSEsLSAFYAVPSDETHFKVCGFYSPAIERTNCWLRSTLIVMQSLPLEFKDLtMQKLWLSYKAGYDQCFVDKLVKSsPKSIILPQGGYVADFAYFFLSQCSFKsaANWRCLcCsMELKLQGLDAhFFYGDVVSHMCKCGNSMTLLSADIPYThcFGVRDDKFCAFYTPRKVFRAACAVDVNDCHSMAVV-GKQIDGKVVTKF.GDKFDFMVGaGMTFSMSPFElAQLYGSCITPNVCFVKGDVI	..................s...................-.pahKVhGLYsPphTRsNCWLRSVLhVMQKLPhpFKDhslQcLWl.YKttYsQhF.VDpLVspIPtsIVlPQGGYVADFAYWFLo.C...DapshA.W+ClKCDhu.LKLpGLDAMFFYGDVVSHVCKCGpSMsLIssDlPaThHFuL+DchFCAFhT.RpVa+AACsVDVNDsHSMAVVDGKQIDs+hVTphouDKFDFIlGHGMSFSMooFEIAQLYGSCITPNVCFVKGDII..............................................	0	0	0	0
+3724	PF00648	Peptidase_C2	Cys_protease_2;	Calpain family cysteine protease	Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.30	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.94	0.70	-5.42	9	2514	2012-10-10 12:56:15	2003-04-07 12:59:11	16	97	332	30	1434	2331	90	246.30	28	35.47	CHANGED	LFpDPpFPssspSLtapphsP.....htlcWKRPsEIsssPpFIlGGAo......RT....DICQGsLGDCWLLAAIAsLTLN-cLLtRVlPtsQSFpEs.YAGIFHFQFWpaG-WV-VVlDDpLPT.+sGc..LlFsHSs-tsEFWSALLEKAYAKlpGsYEALsGGuToEuhEDFTGGlsEaaEL+cAPs...................................NLhc..IIt+hlc+ss.............LhGsShchsss.sshEshphptLV+GHAYSVTGsc-Vph....+Gph.pLlRlRNPWG.pVEWsGsWSDssspWs.lD.--+spLphphp.DGEFWMSFcDFlpaFoRLEICNLT	.....................................................................................................................................................................................W.hR.....s.....t.........c......h.......h......t......p................s........t........h.....h.......t..s.h.p...................t...........s..l..t..QG....l........G.c.....C.a....hl....u....u.l....u....s....l.............s....................p.................p.........h.................h......t..p.......l......h....................t....p................p..........h.............p......p..............p..................h.............G..h.......ap.......h...p.............h.....a.....p............G..p..W...............h.p.Vl.lD.D.h.L...P.............s......h............p.......s....p....................l......h...a.........s........p.........s..........t.p.....t......s......-....h........W.ss.L.lEK...AYA.K......l............t........G...........s..Y...........p......s.l..............p........u.G....p....s.........t.......c.....u...h........c.h......TG..s.....h..s....p.....h...t......h....p..p...s..................................................................................................................................................p.h.h.p......hh..t...p....h....h...p.ptp...............................................h.h.ss....s.h.....t........................t.............t...t....h...t...t...........u...L.......h..t...tH..AY..ul.h...s.h.p.p.......h.p.h...............................................p..Llcl.....+N.....PW...............G......p..................h.......c.....W...p....G........W......u.........-..t...........s...............p....W..........p.........................t.........p....t.......t......h.....................p...................t..................s.G.......F..W.....hs..hp-h.h.p.apth.......................................................................................................................................................	0	477	681	1105
+3725	PF01478	Peptidase_A24	Peptidase_C20; 	Type IV leader peptidase family	Bateman A, Yeats C	anon	Yeats C	Family	Peptidase A24, or the prepilin peptidase as it is also known, processes the N-terminus of the prepilins [1]. The processing is essential for the correct formation of the pseudopili of type IV bacterial protein secretion. The enzyme is found across eubacteria and archaea [2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.44	0.72	-3.88	103	5022	2012-10-02 13:41:03	2003-04-07 12:59:11	13	9	3530	2	1191	3816	981	108.60	23	49.30	CHANGED	llhhshLlhh..uhhDhcpthlPs.......tlsls.....hlhhullht.............h.h.shhshhttlhuu.........hssalhhhh.....................................................................................................hh.....................tht....uhGtGDhKLhuslGshhu.......httl...................hhhlllus.lhGslhsl	......................................................................................................h.hhhshllhh..uhhDhcp........th...l.P.s........tl.s...hs........hh.h.h.ullhs............................................h.h....hhs...h..h.s.s.lh.Gu..................hss..ah...hh..hh........................................................................................................................hh....................t.hp.........uhGhGDlKL...huul.....G...s...a.h.G...............hp.tl........................h.h.l..l.h.h.uu...lhuhlhh.h...............................................................	1	403	759	1005
+3726	PF03510	Peptidase_C24	Endoptase_C24; 	2C endopeptidase (C24) cysteine protease family	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	25.20	26.00	24.70	18.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.36	0.72	-3.86	5	118	2012-10-02 13:45:52	2003-04-07 12:59:11	9	6	60	0	0	131	0	103.30	42	5.21	CHANGED	GYuVHIGNGlYISlTHVAsussclhus-hKss+osGEhChl+ustIp.ousslGoGsPlpDspssPluTshpc+oasTTos+IsGhpsssso..pT+pGDCGLPYlD	.....GaslHIGsGlYlSssHVA+uus.h.spchhshp.ssu.-hChl+ustIt..SsAtl.u.pGpPVp.DshtuPlu.................TthtcKsaoToohKIsGhthsssT..pTppGDCGLPYhD.	0	0	0	0
+3727	PF01364	Peptidase_C25		Peptidase family C25	Bateman A, Griffiths-Jones SR	anon	Pfam-B_516 (release 3.0)	Domain	\N	20.00	20.00	20.00	20.10	19.20	19.90	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.57	0.70	-5.49	77	266	2012-10-03 02:24:44	2003-04-07 12:59:11	13	33	169	1	119	314	445	362.10	21	31.09	CHANGED	hlII....s..ssph.................hstsppLssa+psp......GhsstlVshpplhspas.............sG......sssu.........................IRsalchhasph.s..t...h.ph....llLhGDs................................tt...lPshps...................................................................................................................s.hsoDsaauhl-s...............................................scths-..lslGRlssposppspphlsKllsY-ps...t.....t...........W+pph..hhluss...................................................................................................hp..thtsthtthhst.h.sp+lahs..sh.ppss............................h..............lhpsls.p..GshlhsY..h.G......HGutssh........sstt.............l......shsshpshsNts....phPlhlshoCthupa.sss................ohuEthl......hsssuGAluhlusoc........hsh...................................sss.....spthspthhctlhts.t............p..............slGcshhtu+tphh............................................hsLlGDPulpl	.....................................................................................................................................lII....s....stph.............................hstspcLssa+ppp.......Ghpstllsspplhspas..................G....sstA.........................lRpal+hhaspt.s.......t.pY...llLhGDs.........................................thlsshts.............................................................................................................................sthso.Ds.aa...uhlcs...............................................ss.h.-...lslGRhsspos......p..-spshl.sKhlpYpps..........us................Wppph..hhhuss.....t........................t..............................................................................................................................................................................................hs....thspthtt.th.st....h.hp+lhhs..sh.ptss................................................lhpths.p........Gs.hlh.s.Y..h.G.............HGutsth..................uppp...............................l......shsc.hp.s..hsNts.........phPlhlos.sCthu...pFDtst....................ohuEthh...........hsspu...GAlAhhuooc.hsa...................................ssh...............spthspthhctlhsptts................slGcshphuppphhpt...............................................shhp......asLlGDPulph............................................	0	77	113	119
+3728	PF03785	Peptidase_C25_C		Peptidase family C25, C terminal ig-like domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_516 (release 3.0)	Domain	\N	20.80	20.80	20.90	21.40	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.39	0.72	-4.17	3	29	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	9	1	7	33	38	79.70	41	6.38	CHANGED	PTcMQVTAPAsIstosASasVuCDYNGAIATIScDGcMaGTAVVc.sGsATIsLTcuIT-EoNLTLTVVGYNKlTVIKsIpV	................Ppp.phThPApls.spuShslsss.sGuhssISpsGphaGouVsp.sGsATlNlT.slTs.pushslTlst.NhhsVIKsIps.........	0	7	7	7
+3729	PF03412	Peptidase_C39		Peptidase C39 family	Bateman A	anon	Bateman A	Family	Lantibiotic and non-lantibiotic bacteriocins are synthesised as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Peptide bacteriocins are exported across the cytoplasmic membrane by a dedicated ATP-binding cassette (ABC) transporter. The ABC transporter is the maturation protease  and its proteolytic domain resides in the N-terminal part of the protein [1].  This peptidase domain is found in a wide range of ABC transporters, however the presumed catalytic cysteine and histidine are not conserved in all members of this family.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.43	0.71	-4.34	36	3484	2012-10-10 12:56:15	2003-04-07 12:59:11	10	38	1880	2	701	2968	283	127.90	24	22.09	CHANGED	+h.hlhQscppDCGlAsLuMlLpa..aGpphslscLRphttsstcGsohhuLhpsucphGhcspulpschs.hh....ppl.hPhIsah....phsHahVlhph....pcspllIsDP..uhGphplsppcFpppao.GhhLhhsssss	............................................................t...hh.Q.pt.-..CGh....AsL.shlh.pa.......a...G...p.......p....h........s.......h...t.........p.......L.........+...........c..........h.........h..........t........h............s............t..........p....G.....s.o....h.h....s.......l......h......c...s.A.c..p....l...G.h.....p....s+.s...l...p....h.shp....pl...........spl..s..h..Ps.Ilah......................phsH..asVl..hph.......................cps......p.....l....h..l..t..D.P......uhu.h...h.........p...h.s..h.pc.F..t.pta.....s.....Gh.h.lhh..t..s......................................................................	1	198	417	576
+3730	PF00770	Peptidase_C5		Adenovirus endoprotease	Bateman A	anon	Pfam-B_900 (release 2.1)	Domain	This family of adenovirus thiol endoproteases specifically cleave Gly-Ala peptides in viral precursor peptides.	20.90	20.90	21.20	21.50	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.46	0.71	-4.74	13	133	2012-10-10 12:56:15	2003-04-07 12:59:11	13	1	103	2	0	101	10	176.50	66	88.43	CHANGED	hFLGTFDKRFPGFlucsKhuCAIVNTAuRETGGlHWLAhAWpPpSpThYhFDPFGFSDp+LKQlYpFEYcuLL+RSALuuosDRClTLlKSTQoVQGPsSAACGLFCshFL+AFspaPssPMcpNPsMsLlsGVPNphhpsPps.ssL++NQptLYcFLpp+SsYFRpHpcpIccsTuFs+lp	...........YFLGTFDKRFPGFlu.scKlAC.AIVN..TAGRETGGVHWLAFuWNPRSpTCYhFDPFGFSDcRLKQIYpFEYEuLLRRSALA.o.sDRCloLEKSTQTVQGPpSAACGLFCCMFLHAFV+WPcpPM.DtNPTMsLLTGVPNuMLpSPpV.sTL+RNQEpLYcFLtpHSsYFRsHcspIc+sTAF-+h..........................................	1	0	0	0
+3731	PF03568	Peptidase_C50		Peptidase family C50	Griffiths-Jones SR	anon	MEROPS	Family	\N	25.80	25.80	25.90	26.50	24.70	25.50	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.13	0.70	-5.78	18	368	2012-10-03 02:24:44	2003-04-07 12:59:11	12	14	277	0	272	385	4	306.50	25	21.85	CHANGED	lphspssssL.....lloR..lssspsPhh.l+lPlp+hssp.ts.t.............................shcchccIlppsppss........pspps+ccWWpcRhtLDp+hppLlpslEcsalusapslh.s..h...psshpphspph.shLpptL.scpt..........hphsphlLclh.......................hhsthpcLhhhhlclLpapt.t........uhsEtchphhphhlc-slschppppspp......ppaslLVlDpplpphPWEslssLps.s.VoRlPSlphLhphhpppcsphp.th.hssp........................shYlLNPsuDLspTpccFcs..hFpphts.....WcGhhuphPop-phhcsLpssDlFlYhGHGuGtQYlpspslp+hpppusshLhGCSSstlt.pGp.hcstGshhpYlhAGsPhllGsLWDVTD+DI	...........................................................................................h....l.+...h.........hh..h.hsh..t..t........................................................hhtph.tl.p.t..s.............sttt+ttWWt.tR.t.LDp.phptll........tph-.p..hhu..sa.pslh..................t.......tth.ph..ltp...l.tpt.....................................................p..h.hp.h.........................................t.h..h.....hphht...........................................shs..t.p...h.............h.t..htt...h.t.t.................................tt.hhLllDpp..lp.h.hPWEshshhpt.....s...lsR..hP..Sl.t.hlhp..h....h..........p......t........t.................................................................................................................shallN.Ptu-.....LtpTp..p...php......hpp.............Wp.uhh.sp........Pst.p......p.......h.ptL..t..pp.....c...........lhl.YhGHGuGtpal.ps.pt.l...t.+.......h...........p...p......p......u....s......shLhGC....SSutlt.tG...........p..h-sh...............Gh.hpYhhAG.sPhllusLW-VTDpDI..................................................................................	0	103	169	235
+3732	PF03421	YopJ	Peptidase_C55; 	YopJ Serine/Threonine acetyltransferase	Bateman A, Mistry J	anon	Bateman A	Family	The Yersinia effector YopJ inhibits the innate immune response by blocking MAP kinase and NFkappaB signaling pathways.  YopJ is a serine/threonine acetyltransferase which regulates signalling pathways by blocking phosphorylation [1][2].  Specifically, YopJ has been shown to block phosphorylation of active site residues [3].  It has also been shown that YopJ acetyltransferase is activated by eukaryotic host cell inositol hexakisphosphate [4]. This family was previously incorrectly annotated in Pfam as being a peptidase family.	19.90	19.90	20.30	19.90	18.00	19.20	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.14	0.71	-4.41	17	290	2012-10-10 12:56:15	2003-04-07 12:59:11	11	1	201	0	29	190	4	171.80	37	54.49	CHANGED	spsLhpYuptshsplpsspt...s.shsphDlchLshLstshNpRhPsLNL+hacSsp-hhpulpp.......pssstuhRsllp.....hstsshH+sAlDl+.+.sG+solllhEPAsh.s.t......lsthsphtpphppphhspschshlEsphQ+S.s-ClhFuLshAl+uapcp.shhcplHcs.tpts	................................ctLpshhptlpsplhcGphh..phshpchDlchh..PhLVsptNp+aPp.........LNL+hhp..Ss.p-..h...spuIKp..............ht.puspStRhlls.....hss....sulHhsslDh+......h.....h.sG..Ks..SlIlhEPAshsshsss...............hLuhc.sc.....s..sh.-pp..p..L...P..cs.....hhuhlEhDIQRSso-CsIFSLuhAKKhhhEt.tshs+lH-cphp.t...................	0	2	8	16
+3733	PF03290	Peptidase_C57	Pox_I7L_G1L; 	Vaccinia virus I7 processing peptidase	Mifsud W	anon	Pfam-B_4082 (release 6.5)	Family	\N	21.00	21.00	21.20	281.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.35	0.70	-5.96	11	72	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	43	0	0	60	7	422.30	72	98.86	CHANGED	MDRYTDLVINKIPELGFTNLLsaIY..ShsGLshslDlSKFhTNCNGYVV-+a.DcSsTAGKVSCIPluhLLELVcpthL.......stPsstcp...ELslKctLl......spL+s+Ypshp-lhsLP..TSlPltYFFKPhL+EKVSKAlDFSQMDl+sDDL.S+tGlpsGE.NsKlV+lKIcPD+cAWMSNpSIpsLlu.hua.GoEVsYlGQFshpFLNshslaEKh-hFht+phLualL+DKI+....puppRYVMFGFCYhuHWKClI....aDKccphVsFYDSGGN.PsEFHHYcNFYFYSFSDGFNsNs..cs.SsLsNpNsDlDVLFRFFpssF.ss+hGCINVEVNQLLESECGMFISlFMllCshpPPKGFKulRKlYTaFKFLADKKhTLaKSILF.........Nhschsl-lccl-scul+EYpKME+WTpKuIssLssKIos+sNcIlN	M-RYTDLVISKIPELGFTNLLCHIY..SluGLCoNIDVSKFLTNCNGYVVEKY.DKSsTAGKVSCIPIuhhLELVESGaL.......S+.P.NSSD........EL-QKKELs......-ELKsRY+SIhDlFELP..TSIPLAYFFKP+LREKVSKAIDFSQMDLKIDDL.SRKGI+TGE.NsKVVKh..KIEPERGAWMSN+SI+NLVSQFAY.GSEVDYIGQFDMRFLNSl..AIHEKFDAFhNKHILSYILKDKIK....SSooRFVMFGFCYLSHWKCVI....YDK+psLVSFYDSGGNIPoEFHHYsNFYFYSFSDGFNTNc..++.SVLDNoNCDIDVLFRFFEsoF.GAKlGCINVEVNQLLESECGMFISLFMILCTpTPPKSFKSLKKlYTFFKFLADKKMTLFKSILF.........NLpDlSL-lsEoDNsGLKEYKRMEKWTKKSINVICDKlTTKlN+IVs..	0	0	0	0
+3734	PF00851	Peptidase_C6		Helper component proteinase	Bateman A	anon	Pfam-B_326 (release 3.0)	Family	This protein is found in genome polyproteins of potyviruses.	25.00	25.00	33.40	31.50	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.42	0.70	-5.86	19	1177	2012-10-10 12:56:15	2003-04-07 12:59:11	13	27	145	1	0	1300	0	409.10	47	19.54	CHANGED	pFapGaspsFhch+s.pshsHsCssshs.VcpCGclAAllsQulaPstKITCppChpphpshstcEhtphlpsphppthphhpsthspFsHlpphLchlppthpspNhNhpshtEIh+lls.spppuPFs+lpclNchLlKGspsosp-htpAoppLLElsRahKNRT-sIcpGuLpoFRNKlSuKAplNsuLhCDNQLD+NGNFlWGpRuYHAKRFFsNaF-plDPucGYs+YhlRcsPNGpRKLAIGsLIVstsLcphRpphpGcsIpp.sloppClSppsGNaVYPCCCVTh-DGpPhhSElhhPTKpHLVlGNoGDPKYlDLPpspsspMYIAK-GYCYlNIFLAMLVNVsEc-AKDFTKhVRDhllPcLGcWPThhDVATAChhLslFaP-spsAELPRILVDHsspTMHVlDSaGSLoTGYHlLKAsTVsQLIpFAsssL-SEMKaY+VG	..................................................................................................................................................................................................................................................................................................................FW+GaspsahphR..h.s.ps.H..p.C.t.s.s.ls.lcpCG.clAAlhspulhPChKITC.pCspchtphstp-.htphl.pp.phpphtp...p...hts.hs....cFt+....hhphLphhcp..h..h..psts..t..sh..phht-lhchls.phppssapplpclNphLlKG.s.ps.Tsp-hppAoppLLEluR..ahKNRp-slccGsl.psFRNKlSuKA.....plN.sLhCDNQLDpNG.NF....lWGpRt.YHAKRFFuNYFE.lDPscGYppa.hRhpPNGpRKLA.IGpLllPhshpphRcphpGc.lpp.sloppC.lSp.psssaVYsC.CCVTh-DGpshhS-lhsPTKpHLVIGNSGDsKYlDLPps.c.sppMYIAKcGYCYlNIFLAMLlNlsEp-AK-FTK.hVRDhlls.cLGpWPThhDlATsCh.LplaaP-stsAELPRILVDHpsphhHVlDSaGShooGYHlLKAsTVsQLIpFspssL-S-hKaY+VG......	0	0	0	0
+3735	PF01830	Peptidase_C7		Peptidase C7 family	Bateman A	anon	MEROPS	Family	\N	20.50	20.50	70.50	70.50	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.77	0.70	-5.22	14	61	2012-10-10 12:56:15	2003-04-07 12:59:11	13	3	5	0	0	57	0	157.40	65	35.17	CHANGED	MSCLRKPSQSLVLSESVD.....PTT.....VD..PFVDVRAEEVVPTGCMTLWEYRDSCGDVPGPLSHGDLRRLRTPD.GVCKCQIHFELP....TVLKSGSTGTVPEHPAVVAAFMGRPRRCSLEQRTKELDFRFLQLVHEGLPVRPSYMIARPPRPVRGLCSSRDGSLAQFGQGYCYLSAIVDSARWRVARTTGWCVRVAcYL+LLQWVGR+SFGSFQIEESAVEHVYHVI.......VDTEaQSEQDGALFYQAVSDLAARDP	.....................MSCLRcPSQuLVLstS.D.....Pso.....lD..PFsDVtsEEVVPpGChTLWEYRDSCGsVPGPLSHGDLh+L+TPD.GVC+CQIHFELP....TVL.......................................................................................................................................................................................	0	0	0	0
+3736	PF03569	Peptidase_C8		Peptidase family C8	Griffiths-Jones SR	anon	MEROPS	Family	\N	21.60	21.60	22.20	228.00	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.45	0.70	-5.03	2	18	2012-10-10 12:56:15	2003-04-07 12:59:11	8	4	4	0	0	20	0	161.60	79	15.59	CHANGED	hARuIGlSptustELVRsT+VsEsKPHLsPMpEAp.s.cQ.L.stRuh.Vssc.tslEls..clPscEGcCa.h.Fp.s.hT.hIhspKP..p-lluhhp.sssThDSL-Io+psthVHh.sG-sapsY+pIhAhLc.h.h.s.p.hlVGAcpspltDYVtAutpFLhp..pWl+NGL+lAtthhpPt.lhK..h.NsShP+sl.psD..YIp	LARAIGLSHsAsuELVRAT+VDEsKPHLVPMEEhKEAPRQQLVPRRSTFV-NHEEEVEVDsLRLPTEEGRCFELLFN.NQlTPAIFDKKPLLRDVL-VFEENVCThDSLEISHSD+CVHIVPGETFRNaKEIKAVL+VILWN-P-.ILVG...............................................................	0	0	0	0
+3737	PF01707	Peptidase_C9		Peptidase family C9	Bateman A	anon	[1]	Family	\N	25.00	25.00	115.50	114.60	22.30	20.00	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.34	0.71	-4.72	8	257	2012-10-10 12:56:15	2003-04-07 12:59:11	11	7	47	2	0	311	0	192.80	66	8.58	CHANGED	DPWIKsLTNsP+GNFTATlEEWQAEH-uIMpuIpspusssDsFQNKsNVCWAKuLlPVLcTAGIcLTsEQWsslh.sF+-D+AYSPElALN.ICTKaaGlDLDSGLFStPoVPLoYc.......ssHWDNpPGG+MYGaNppVAtpLp+RYPhlptthcoGcQlslspt+lpshsscsNllPlNRRLPHuLVspacppcuuchEphlsK	DPWIKTLpNsPKGNFpATIcEWcsEHsuIMAuIss+thohDsF.QNKANVCWAKuLVPlL-TAGI+LsccQWSpIl.AFKEDKAYSPEVALNEICTRhYGVDLDSGLFStPhVSlaYt.......sNHWDNRPGG+MaGFN.EsAshLER+YPFh+Gphsh...s+QlsVsTR+IcDasPssNllPsNRRLPHSLVsEH+ss+GpRhEWLVsK........	0	0	0	0
+3738	PF00413	Peptidase_M10	matrixin; 	Matrixin	Bateman A, Finn RD	anon	Prosite	Domain	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null --hand HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.42	0.71	-4.50	66	3213	2012-10-03 04:41:15	2003-04-07 12:59:11	19	158	1096	316	1273	3093	388	160.90	27	39.87	CHANGED	+W.p+.pp....LTYplhsho..sclspspVcpslc+AFpsW.ucV......oP.LpFpclt.......p...s....ADIhIsFs............pspHGDshP..FDGsuG.........sLAHAahPs..........hsGDsHFDsDE...pWThs...............................................................................................................................................................................spGhsLhhVAsHElGHuLGLsHSss.sAlMaPhYp.ht.p......pLspDDlpGIQpLYG	................................................................................................................................................................................................................................................................................................................................................................................h........tt.h....pp....shtpA.hp..h...W.sp.s.................ss..lp..Fppl.............p.tp..........ADI.h....l.t.Fh..............................p.t..t..c.....s......s.........s...............s......a.......-...u......s.s..........................hL..A+.A....ah..Ps..............h..tGss....H.a..-...t...s.c.......a.s.h.s...........................................................................................................................................................................................................p...s..h.s...L..h..h.VA...s...HElGHuLGL.s.H..........o...........s......s..................p........u...l...M.h.....P.h.hp..h..................tLtt-Dlpu..lptlY...........................................................................................................................................................................................	2	289	498	817
+3740	PF00675	Peptidase_M16	Insulinase;	Insulinase (Peptidase family M16)	Bateman A	anon	Pfam-B_88 (release 2.1)	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.58	0.71	-4.45	26	11461	2012-10-02 15:41:56	2003-04-07 12:59:11	15	55	4386	192	4038	9720	2217	136.00	20	22.38	CHANGED	pVsspps.ssspuslulhlssGSthEspp.sGlAHFLEHhhFpG.Tp+hss.ppltphlcphGGph....NAhTscEpTsYhhcshscs......lspul-hlu-hhtps...thscppl-c........Elptlcsch.....lhctlcssuaptpsLupslhsPt	.........................................................................................stht.lhh.t.s.Guh........t-...s.....t....t..p...........s........G...l.A.Hh.l..E.H.............hh..Fp............G......o.....p..p......h......s.....s....t....p.....ht..p.hl.p.p..h.G....u.p.h...........................NAhTu....h....-........p..TsY.h..h....p....s.........s..pp....................................lp..p..s.l.......p....lhs-...h....h..t.p..s...................t.h.s..p..p.p...l.........c..p...............tp.........t....h....h..h..t..E.h.p......h.psp..............h...t.....h.................t..........................................................................	1	1413	2529	3444
+3741	PF00883	Peptidase_M17		Cytosol aminopeptidase family, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_990 (release 3.0)	Domain	The two associated zinc ions and the active site are entirely enclosed within the C-terminal catalytic domain in leucine  aminopeptidase.	25.00	25.00	25.00	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.89	0.70	-5.55	17	5342	2012-10-02 19:46:12	2003-04-07 12:59:11	16	21	3337	121	1482	3949	3549	304.00	41	63.96	CHANGED	lthuR-LhssPuNhlsPshhAcpApclupshu...lplpVlcpcphcchtMGuhLuVupGS..ppsPphlhlpYpsst.....cspphluLVGKGlTFDSGGhsIK..sussMctMKhDMuGAAuVhushpAluplchs.hsVhsllshsENh.SGsA.+PGDllsshsGKTlEVpNTDAEGRLlLADulsYApp.hssctlIDsATLTGAhslALGsshsGlaoss-pLtcplhpAuppuGEtlWRhPhp-c.YhcplcS.slADls..NhusttG..GuhTAAhFLppFlpp.....WhHlDIAGsshtpptt......GuoGhsVpTLsp	..............................................h..hsRDLsNtPsNh....hsPstlAp....p....A.....p....p.lspphu............lps...c.l.l...sp..cplcchG..hsuhh.....uVG+.G....S.....pp....sP....t....llhlc...............Ypsss...................t........ss...t......lsLVGKGl..TFD.................o.....GGlSlK......Pu.s..sMc.pMKhDMuGAAsVhGshps..lu.p.h.........p..L.....s.......lp....Vhullss.s...ENhsuGsA.............h+P................GDllTshs...........GpTVEVhNTDAE.G......RLVLADuLsY....Apc.....h............c........P..c......h....l....ID.....hA.TLTGAs...h.............lAL...G...p.c...h...sul....h....os....s....-....s..............L...s....p....p..l....htA...............u.ppss-..h..h..W..+L....P.....L.s.-..........p.....a....p.....c.p........l..c.........S...sh...A.D.ls........N..h.....u..u.p.t.s.........Gu......lTA......AtF......L.......p......c.......F.....s............c................p.....................................h.......sWsHl...DIAGsuhpssst.........tG.uTGhsVphLs.p........................................................................................................................	0	495	885	1213
+3742	PF01401	Peptidase_M2		Angiotensin-converting enzyme	Bateman A, Coates D	anon	Swiss-Prot	Family	Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.	19.40	19.40	19.50	19.50	18.70	19.30	hmmbuild  -o /dev/null HMM SEED	595	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-13.13	0.70	-6.32	6	802	2012-10-03 04:41:15	2003-04-07 12:59:11	13	14	230	68	446	817	299	468.30	35	85.85	CHANGED	DsshpssshssDEAtAphFsEpYspSApsVh.c.stAsWsasTNITsEsu+h..Ecuh.sppas.saGp+AKch.ss.aQNhT...l+RIItpVpsLspAsLPltchppYNplL.sMppIYSsupVCaPN..uoChsL-PDLTNlhAoSRpYscLLaAWEGW+DtVGhslhPhY.castlSNcAhR.sGaoDsGs.WRShYESPohEpDLE+LYQpLpPLYLNLHAYVRRALHR+YGscYINLcGPIPAHLLGNMWAQoWpNIYDhVVPFPstPNlDsTpsMlpQGWssp+MF+.A--FFTSLGLLPhPPEFWscSMLEKPTDGREVVCHASAWDFYNtKDFRIKQCTpVsMEpLssVHHEMGHIQYahQYKDLPVoLRcGANPGFHEAIGDVLALSVSTPcHLHpIsLLsp.ssshEpDINaLhKMAL-KIAFlPFuYLVDQWRWtVFsGphspppYN.-WW.LRhKYQGlCPPVsRspscFDsGAKFHIPussPYIRYFVSFllQFQFHEALC+tAGHpGPLHpCDIYQSpcAGt+LtsshphGhSRPW.EshKslsGpsshsApAhLsYFpPlopWLpppNpRpGEsLGWPEYpWpP	...........................................................................................................................................................................................................................................................................h..hht..p.....h.......utW..ts.ls.t....s..................t..h..t.......t.t.h....................t....p....s.t.t..h..............hps.p.......h+..p.....hthl..t........t.....s...s.l........s......t.c......t..ph...t....pl....h..s...p...Mpt......hYutu...ph.C..........p......................tp.C......h......Lp.....P......p...lpp.....lh...s......pS+.......sh..........pchhasWpuW+ptsG..h.....h....+s.a.chV.t...LtNc..sAp....s.................satsh.uth.W.....p..t....Y.....-......................s..........p..........h...........pp.....l-.pla......p.....plpPLY.....pLHuYVRtpLhptY..G...p..h.l...s........p.G..s.lPAH....L....L.....Gs.MWuptWs..sl...hsh.hhP..................a.s..t.t..s..t.h..D..l.o..........t...t..h.hp..p.s.a.ss.......chap.u-pFFhSlGh......hs....pFW.ppS...hh..p.c....PtD...R..cl..lCH.s.o.A.WDhh.......t........t.....t.........D.......h..R.....IK.Cs..p...ls.h-...phhshHHEhGHlpY...ht...Y..p..p...Ph..hh+pGA.NsGFHEAlG-hhuLSssTPp.......aLp.p.lGLL..p.p........................t...s......................c..............t..p.........IN.......h.L...hp...ALppl.shlPFsh.hh-pWRWtVF.pGp....ls...p..p....aNptWW.ph..+.catG...l.hsP..l...Rs.p.p...hDsuuKaH..lss.s.hs.a.h..............RY..ahuhlhQFQFacuLCpt........u........t.........p.......p.......s...........P.......L......ap.CD.lh...t.sp...tAGph.Lt.phh.phGtSp.....sW.psh.............p.hs..G..p..p...p.......hsspsl..hpYFpPLhpWLpp.pNt.....hGW................................	0	164	207	346
+3743	PF00557	Peptidase_M24	pep_M24; 	Metallopeptidase family M24	Bateman A	anon	SCOP	Domain	This family contains metallopeptidases.  It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3].	20.70	20.70	20.70	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.78	0.70	-4.75	656	20523	2009-01-15 18:05:59	2003-04-07 12:59:11	19	77	5099	201	5995	15852	9743	218.60	23	58.35	CHANGED	pth+pAsplsspshp.th....h..t.......lc...s...........................G.........................h.........o..-t-lsshlp...h......h...tp.......t..u...........tpth..........ua.....s...sllssG.sss...h..........sHh...hs..........s.tpt................l....pp....G.................................-l..lhlDhGsph.....GYtuDhoRTh....h..h.......G................s.....t.......cp.la.......phlhcup...p........tul.p.tl.+....P.G.....s...........p..hs-lsptspphlp..p.......h......G.h...................................thhh+.......thG.H........GlG......l.plH...tt..............................P......h............l.....s........................................................tt......tth.........Lc.....sGMlhol.EP.................Gha..........h.s.....................................................sh..........................................................................h.Gl+lE-......sllloc	.....................................................................................................hh+pAsplss.pshp.th...h.....ph..........lc.........s...........................G.................................h..............o.....ph-...l..s..thhc...ph........h.........pp.................tu..........................hsth.....ua..........s...shlss..u..hN.ss........l...................sHh.....hs....................s..sph...........................l.......cp.......G.................................-l.......l.h.l..Dh..G..s...h...hs..............G.atuDhoRTh...h......l............G..........p.ss.....p.................................tcc.lh...............p.h..s....h....c....uh...................tul....p...th....+.................P...G........s................................p......ht-.l...stthpphhp..p...............t.............G.h...................................................thhtc........hsG.H....GlG............h...ph.H.....-t............................................P.......l.............................................................................t....pshh.....Lc................GM.....lho...l..EP....................ulh............s...........................sh...................................................................................................t.usphEc...slllT..........................................................................................................................................................	1	2007	3696	5023
+3744	PF01742	Peptidase_M27		Clostridial neurotoxin zinc protease	Bateman A	anon	Pfam-B_407 (release 4.2)	Family	These toxins are zinc proteases that block neurotransmitter release by proteolytic cleavage of synaptic proteins such as synaptobrevins, syntaxin and SNAP-25.	20.10	20.10	20.40	20.60	19.20	20.00	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.48	0.70	-5.61	13	216	2012-10-03 04:41:15	2003-04-07 12:59:11	12	5	34	118	5	238	0	366.70	42	32.95	CHANGED	hsIN.sFNYsDPVsNcsIlhl+...sctsspaaKAFcIssNIWllPERa.aGpsPs...hstssplpuh.s.uYYDPNYLoTDsEKDcFLpshIKLFpRINssssGcpLLshIssAIPahGs............................spT..spFssspcosslshK..p....sspshhhsNLlIFGPGssIl-ssshshp.......sppsucpGFGoht.lpFsPcasasFsss...........p.FhsDPALpLhHELIHuLHtLYGIK.ssshplh.ppps.ahstpts.lphEElhTFGGpDhplIssssppplhshhLssa+sIAp+LNplpos.sss..h.lspYKphacpKYphsp-ssGpasVNlsKFsclYppL...aTEpshustaplpsRppYashcYh.hph.slLssslYsIp-GFNluphshplshsGQNtplNs	.....hpIN.sFNhssPVDNcsllhl+...sctsspaaKAFcltsNIWlhPERa.aGps.p...hscs.phcs....uhYDssaLsTssEKDpFLpshIK.LhpRINssshGcpLLphIssuIPa.hs............................pps..tpatthhposhls.p.......sspphhhsNllIhGPGssIh-spsh.ht........p.sucpGhGoht.lhFpP.hsatasp..............FhhDPAlpLh+pLI+uLahLYGIK.sssh.l.hp.ps.h.p.phs.lph.-hhs.GGpDhphIsss....h.shhhssh+shtpphNchpspltss....hN.hK.hhcpKath..sspshaslslshFsc.ap.l....h.p.phspthphhpRppYa.hsas..........c.YsI.pGFs.sphNhplshpspNpsI.s.........................	0	2	5	5
+3745	PF02073	Peptidase_M29		Thermophilic metalloprotease (M29)	Mian N, Bateman A	anon	IPR000787	Family	\N	21.50	21.50	21.60	21.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.29	0.70	-5.70	73	2095	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	1554	6	468	1517	492	367.30	34	92.86	CHANGED	M....hcpplc+aAcllV.....chGlslQtGpplllpus.hc.stchs+hlsccAYctGAtpVhlpas......DsplsRhhhpt.usc-p..hc..phPpach...pphhccssuhlulhu.pssshLssl-sc+luthp+At.sts.hcthhpth.tsthsWslsshPotuWAp.h.....psp.ul-phh-hlFcss+lDtt.sPltsWcp+scplpphschLNcpph.pL+ap.us.....GTDLolplscp+hWtuust.sp.....hhsNhPotEVFTuPhcpsVsGhVpsspPLsapGsll-shpLsFccGclV-hsA..cpGc-hLpcll-TD-GA+hLGElALlsssu....hshhhaNTLFDEN.....uSsHlAlGpAYstsltsG.t.........tGhNcShlHlDhhlu........usclplDG...tsp..slh+sGsa	..............................................................................................................................................................................hcppLc+hAclll.....phGl.s.lQ.Gpplhl.....pss.....lp.thtL.s.+hlsccAYp.hGAt.Vh.lpap......Dpt.lp+.hh.tus..-p..hp.........phspach.t...t.t.h.h.cp..t..s..uhlulhu......psP.....shhssl-..s.....p+ltthp.psh.utu..hc......hhpthttsphsWslsuhP.s.tWAp.las........ssctuhp.thh-tlFc.ssR.l.s....t..sPl.t.sWcpHsptL....pphsc.hLNc.pphttLH.as...us........G...TDLTluLs..c..p..+..h..W.p.s.us.s.hsstt.......hhsN...h.P.....T.....EEVFTuPspp.........p....ls......GhVs..s....s...p..P..Ls...Y..s.G..s..l.I...-.s..hplpF..c..cGcIV..-hsA................cp.G..c....c...hL......c.c..l.............l............p..s..D......E.............G.............A....+h.L...GElALVsssSP.....Iuppsh.....h.Fa.....N....TLFD......EN.....AosHlAlGs...AY..s.......h.......s......h............s......G.t.......p..h.......s.......c..p..........h.......t...tGhN.p.S....................l............HhDaMlG............osch.s.lDGh.tsGp...lh+sGpa.....................................................................	0	181	345	417
+3746	PF01432	Peptidase_M3		Peptidase family M3	Bateman A	anon	Swissprot	Family	This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence.	19.80	19.80	20.00	19.80	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.57	0.70	-5.45	29	8043	2012-10-03 04:41:15	2003-04-07 12:59:11	15	23	4148	12	2004	6381	1947	390.10	24	63.94	CHANGED	hhhpspscplR+psapAhhpphtp.t.....h..stllpchlph+......AclhsasoatphsLts.hspsspsVhsFLtclhpcttPhhcc.hphhpphh.tt.......hshp...clpsWDh...........as......lspp.hp.aFsh.ppslp..................................tpsapp..............ptshhuphalDhasRcu.KtuG..Aashshhst...............................................shshllhNasp.................shs-l.pTLFHEhGHuhHshhoppp.shhssh.sss.....h-hsElsSph.Ethhh-hthhthhs..chpstts...................l.pchlpphh........h.thhRQlhhuth-hplHpttp.st..s...h.c..atplppchhs..hssss.......sp.th.s....ths.l.....thYsusYYsYhaupsh..usshapphhc.s...s.........chhpphLptGGStsPh-hlcphtsc.spscshhcshsh	...............................................................................................................................................hh.spspplRcphapuhh.pthp......p.......................t..............p.........h...sthh.pphl.ph.+tth.....................Ap...lhGap...s...h.t.....p...h.....t...L..t...s.............s...ps...s...pp....l..h..s.h.L...p.l.h.p.p.t....h....sh...h.p.c...ht.hpp...................................hGhp.......plp..aDh............................as..................hsp.tt.h.c......h.hsh.pp.....s.hp...............hhh..t.h...sh.........................a..p..........................................................ptth..............sphal..Dha.............s+..p..u....K....pu.G....Aahs.shhst..............................................................................s.hsa..l......l...h...Nast.....................................................shs-............l.hTL.hHEhGHuhH.p.h...h.o..p..p.p......s..h..sss...sss.................hshsEhsSph.....Eth....h.hc....h.....h.p.h.h........c..h.c...p..t.t..s................................................................l..pp.hl...c..p.hh.................................h.thh.cpl..h.u..hF.-hpl..Hpt.........pt....s.t..............t.............lsp..hhtp..lpp...ch..hs........sh..............................s.p..thsh.........tau+l..............thY..t..s..s..a..Y..s.........Y..h..a..u..p..sh.......ussh.a.p..t....hh..c....p.u.....s.........................h.......ch...h.p...hL.p.t.GuSp.p.s.h-.l.h.c.t.h.t.s.c..sp.cshhpt...h.........................................................................................................................................	1	652	1241	1669
+3747	PF02074	Peptidase_M32		Carboxypeptidase Taq (M32) metallopeptidase	Mian N, Bateman A	anon	IPR001333	Family	\N	19.90	19.90	19.90	19.90	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	494	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.46	0.70	-5.87	3	1205	2012-10-03 04:41:15	2003-04-07 12:59:11	10	5	1118	17	345	1078	910	472.10	36	95.91	CHANGED	MphcsshKElL-hhRRIuaLGcAsALhuWDpRTshPKcGpt-RAcuhGpLSsLlaEltTcPRhsELlEKlcGp..hEDLsEDs+ssVRlh+RpYEcsKuIPEchhKElupssSKAETAWEEAKuKDDFStFpPYL-+LIuLAKR...hlpYlG.YpE-P.....YDALLDLYEPGlRsRDL-pLFcELccuL+PLL-+ILuSG++PDsusLcK.+YPKEtQ+cluLalLQchGYDL-u.GRLDsTAHPFsTslGhGDVRITTRY-EcDFRsAIFGTIHEhGHALYEQslDEAahGTPlu-GASLGIHESQSRFWENlIGRSKcFWEhaYP+lKEsh.sphcDloLEDFahAlNtV+PSFIRVEADEVTYNLHILlRaELE+AlFSsEVplEDLPEhWN-KYccYLGIsP+TY+EGILQDVHWAGGsFGYFPTYoLGslYAAQLatKhpEDLP-FEsLlARGEFcPIKsWLREKIHtaGSRa+P+-LlK+ATGE-lNAcYFlRYLcsKY	.........................................................................h.......pphh.phhcc...lp.t...hp.phhulhtWD.pT.hMP..p.tG.s..ptRu-shuhLush....haphhT....s....sp....hs....ch....lp..ph...c..pp..............p..p.....L....s.........p.....h......p.....p....t....slcc.....h++p..a.ppsptlPtphhpthsthsucucpsWcp.A.Rt.p.s.Das.tFtPhLpcllchp+c.......hhph.h..u....h.t..p..s..s.........................YDsLL-.YEPGhTsppL-plFspL+....ptlssLl....p.pl.hp.p.....t.....p....p........p...s...s..h..lp.t...p............as.......tcpQ.cphsh..pl.h.c.hl.GaD.Fsp.....GRL.Dp.osHPF.ssu.ls...s.DVRITTRY.sEs.-FhpulhuslHEsGHAhYEQ...s.l...s...c...p...ht....s.o.P.l.....u.........putSMGlHESQSLFaE..lGRSpuFhphhhsh.hpcth....sph..s...s..h.....s.h..-..shacthscV.c.su.h.IR.l-ADElTYs..hHlllRYElE+tLhsG...plpVp...DLPphWNcKhpp..Y.LGl.p.s.p.s.c.tp..GsLQ...DlHWosGsF.G.YFPoYsLGshYAAQhhpshpcsls...........s........l..-s..hl.tp..G-.hsslhpWLpcpIapaGsh.h.s.s.p.-Llpcu.T.G.E.s.LNspahhcaLcp+Y...............................................................................................................................................	1	111	208	279
+3748	PF02102	Peptidase_M35		Deuterolysin metalloprotease (M35) family	Mian N, Bateman A	anon	IPR001384	Family	\N	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.12	0.70	-5.80	4	234	2012-10-03 04:41:15	2003-04-07 12:59:11	10	2	67	1	138	280	1	281.40	31	91.47	CHANGED	MRhTsLuoAlLALAssslAhPspos.uPsLDVoLoQVDNTRIKAVVKNTGuEcVTFVHLNFF+DuAPVKKVSlaRp..................ssEV.FpGIKRRhpopGLoc-uLToLusGEolEDEFDIAoToDLopGGslTIRocGFVPIssDsKlTGYlPYpSN-LplpVDuAKAAsVspAlK.LDRRTKVssCsGoRpSALoTALpNsspLANtAAoAApSGSuS+FpEYFKTTSppsRosVAuRhRAVA+EAuSsSSGSTTYYCsDsYGYC-oNVLAYTLPupNlIANCDIYYSYLPALspoCHAQDQATTTLHEFTHAPGVYSPGTDDLGYGYcAATuLSuSQAL.NADoYALaAN.......ulclKC	.............................................................................................................................................................................................................................lpl....p.....l.......................t.t.......hps.lpNtutp..hp.hhp.h.t...h..s.t....spph.l..t.t..............................t.t..h..FtGhh...h...ttl.........p..h..l.sttohp.......hs.hA.h.ph..t....t.....h..h...........t...s.......h....h..h.............t...........................s.......h.......h...ss..ht...h.t.s.............s.................................h..................................t........c.Rs..p......h..s..s.......C.s.s.s.ptstl.psALpssupLAptAtp...A...s..p...s...t.s....s...phappaFKoss...sphp.phVtspF.ptlupEs.sps.s.sups.ohhCpD..s.h.s...h..C....p.....s.....s........s..lAYT.....l..s.s.......p..s.....ls..C.Pha.....as....p..hP..s..h......o.ppC...p...u..t...D.......Qs.T....ohLHE.hoHh.thh.......tsp...Dh..u.YG.apssppL...su...s...p...ulpNADoYulFAps............hhht....................................	0	38	76	114
+3749	PF02128	Peptidase_M36		Fungalysin metallopeptidase (M36)	Mian N, Bateman A	anon	IPR001842	Family	\N	23.30	23.30	23.30	24.00	23.00	22.90	hmmbuild  -o /dev/null --hand HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.28	0.70	-5.62	31	458	2012-10-03 04:41:15	2003-04-07 12:59:11	10	28	290	0	202	440	80	321.30	31	49.08	CHANGED	AsYpVYPaslssPsc.......GsRsllssP.hss..hASPauWpsssss...paTs...TRGNNshA.ps..ssussth.....sshpPsu.....ssLpFs.aPashshs.Ps.........sahsA.ulTpLFYhsNlhHDlhYphGFsEtuGNFQhNNhGpGGtGsDhVlspAQDGSG..................hNNANFuTPPDGpssRMpMYlWstss.................................................................................................................................................................PpRDGsF-uGIllHEYsHGlSNRLoGGPuNosCLss.p............ouuMGEGWuDahuhslplKsuDTtssshshGsasssps...sGIRsasYSTshshNPhTYssl.......sshsss........HulGsVWAohLaElhWsLIDcaGhss.....sha.........tsG.....GpplAMpLVlDGMtLQPCNPsFlpuRDAILsADhslssGtNp.......CpIWcuFA+RGLGhuAp	........................................................................................................................................................................t.........................................................................................................................................................................................................................................................................................................................................shp.....................u...........ttD.h.h...s....ts..................hN.NAshtss...s.D...GpsschphY.hsttt..........................................................................................................................................................................s.hD..suh..-AuIlhHEYsHulps+hssG.uss...t.t...p................uGuMGEGauDahAs.sh.ph.................p......ss....s.p.......t.......t..s.......s.......h.......s....h..Gp.......ass.....s..........s.....................s..........s..lR...p.h....sh........ss.......p........s..N..s........hsa.ssh...............pths.pl...................HshG....plWushLa-hhhshlp......p.h.Ghs...............s.h...........................................Gp.lhhpllhpuh.h....ss.......s.spFhpu+cAIhpADthh...hs.....Gtpt........s.l.chaAtRGlu....h...........................................................	0	108	146	176
+3750	PF01447	Peptidase_M4		Thermolysin metallopeptidase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Psiblast P06142	Domain	\N	22.20	22.20	22.20	23.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.20	0.71	-4.10	13	1948	2012-10-03 04:41:15	2003-04-07 12:59:11	13	69	1073	112	314	1608	50	143.00	32	26.78	CHANGED	sssstsGctVhGc......tp.lsls+sust..ahLpDsTctss..lpoYsussp........hohsuo.......lhpssssshs.....s.tuuuVDAHaaAthlYDYY+shasRsSlD...spGhplpSpVHY.....G..ssYNNAaWsGspMlYGDGDs...sFhPLSuslDVVuHElTHGVTEp	.......................................................................s...thGh..h.st........sht.hst.sst........a.h..-.s.p...t....t....h............................tshshppt.................sh..st..................hh.p.sp.spshs.........tps...susD.Aa...a.h.u.stsa.Da.Y+...sh.asRsSlD.......spGhtlhShV...Hh..........u.....ps..a..s.NA..F......W.......s..G.....s...p..M..saGD.G..-s...............h..Fh.slsuulDVsuHEloHGVTp.............	0	95	182	266
+3751	PF03410	Peptidase_M44	Protein_G1; 	Protein G1	Finn RD	anon	Pfam-B_4417 (release 6.6)	Family	Protein G1, named after the vaccinia virus protein, is a glycoprotein expressed by many Poxviridae.	25.00	25.00	131.40	131.30	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	590	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-13.06	0.70	-6.26	3	79	2012-10-02 15:41:56	2003-04-07 12:59:11	8	2	49	0	0	69	0	519.90	70	99.81	CHANGED	MIVL-NGVRVFINsuMsKDIYlGlSNFGFENDIsEILGIAHLLEHILISFDuTRFVANASTARSYMSFWC+uIRuc.TplDAlRTLVSWFFu+GuLKDDFSlS+IRaHIKELENEYYFRNEVFHCMDILTFLuGGDLYNGGRLSMLDpL-sVR-lLscRMRRIuGPNVVIFVRELuPusLuLLspTFGoLPACPpTIPuTlhsSIsGKsVMsPSPFYTVMV+V-PTL-NILuILCLYEoYHLVDYETlGN+LYVTFSFIHEpDYEuFLRGsGcLplo.spRIcLNYSDDYlMNlYLNFPWLpHDLaDYLTplNsDosSlLpSLEc-IYpSVRsRDlIVVYPNFSsoMsNTRDRQpH+lVVLDs.NluhuupPsRSIcLMKRQT+NElFIRYGDAuLlDYVsLALu+.RchuL+Rps+GIRl+HuFSADDI+sIMESDTFlKYSRSKPAAMYQYIFLSFFASGNSI-DILp+RESlVcF.uR+sKNKIVFGKpARYDVsTKSSFVCGIlRGPpLocsuLT-hMW-LKRKGLIYSLEFTcLhuKNTFYLFsFTIYPE-VYcYLuopKLFSu+ClVVSpKG-sEDFSSLKKDVVI+l	.............MIVLPNKVRIFINDcMKKDIYLGISNFGFENDI.DEILGIAHLLEHLLISFDSTpFLANASTSRSYMSFWCKSIput.opsDAIRTLlSWFFs.N.G.KLKDNFSlSsIRhHIKELENEYYFRNEVFHCMDlLTFLuGGDLYNGGRIsMl-NLshVccMLsNRMpRISGsNIVIFVKcLssuTLshhppTFGoLPuCPElIPss.hs.sossGKIVMhPSPFYTVMV+lsPTLDNILuILhLYEsYHLIDYETIGNQLYlTlSFIDEo-YEuFLRG.ul....LplupsppIs.hNY.oDDYhMNIYLNFPWLuHDlaDYITcIN-cocslLhSLps-IYsSIlsRDhIVIYPNFSKuhhNocDsQpH.IVVL..................Ds.....sN.....c..s..hh.....+........+...P.......h.....psIs...........LMK+.h..T.s.NEIaIRYGDASLhDhlTL...uLSh....pDhsL...+..RssEGIRl+HsFSADDIpAIMESDoFLKYS+SKPAAMYQYIFLSFFASGNSI-DILsNR-ST.Lch.uK+s.KsKILFGRNTRYDlssKSSFVCGIV+GKsLccsoLs-hMW-LKKKGLIYSMEFTsLhSKNTFYlFsFTIYsDEVYcYLsssKhFou+CLVVSsK...G...-lEsFSSLKKDVVIRl...........	0	0	0	0
+3752	PF01427	Peptidase_M15	Peptidase_M45; 	D-ala-D-ala dipeptidase	Bateman A	anon	Psiblast Q47749	Family	\N	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.35	0.71	-4.70	5	2743	2012-10-02 01:02:30	2003-04-07 12:59:11	12	9	1142	6	295	2325	328	113.20	39	86.22	CHANGED	cssGhlsLcpllsDlchDuKYATtDNFTGK..shYpssRsLucc-sApuLtcApulAsspGhsLllWDuYRP+sApsshhtWsAsPEsshst-sthssIp+sth.s...suopSoHSRGoAIDLTLh+sDpGpLVDMGocFD-McERSHssAsu.VussuspNR+..........pLRuIMEuuGFpuYSuEWWHFcLsDps....Yscsah-FsVs	........................................................................................................................FTG+..l.............ssY.....s...sR.hlhp.csh..s...sALtpA.pp..p..A..p..s............G..as.Llla.DuY....R.P.QpAs....p......t........h......h......t.....W.......s.......t......p..........P....................................................................................................................................................................................................................................................................................................................................................................................................................................	0	109	194	256
+3753	PF01435	Peptidase_M48		Peptidase family M48	Bateman A	anon	Swiss-Prot	Family	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null --hand HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.52	0.70	-4.79	21	10571	2012-10-03 04:41:15	2003-04-07 12:59:11	13	115	3867	4	3276	8591	3845	215.40	20	61.15	CHANGED	hhhlhsshhhhphst.hhtplhtph............stppsplcphlpclApps....sh.....hclhVlcssp...............sNAFshstup....lslpsuLl....pt......................................hscsELtAVlGHElGHhttpHshhp..hhhuhhhslhhhhshshhhs.thh.tttt.......................hlhthhhhshSRppEhpADthuhph........hhpshhp.t..........hshhtplpp.......................................ttssssshhsthhpTHPshspRlpt	.........................................................................................................ht.................................t................................t...t.......l.h...p...h..s.p....p...l...spps..............s..h.s...............p..l...h..l..h.p..s.sp............................hNA........F......A......h.......s......s.....s..........p...........................l.s.l.psG..Ll.....pt.............................................................................................hsc..s..E..l.tuV.luHEluHlt..ptchhpt...........h.h.......t....s...h......h...s............s....h......h....h......h.........h.......s........t.........h......h..........h.........h.......h.....h......s........t......h.....t.........t..s....t............................................................................................................hhs.t.h..h....h..t.h...S...R...p....p.E..hpADthuhpl...........hhpuhhp.psh.................................phh..p.p...h.tt.......................................................................................h....t....s......t....t...h.......s....p.......h....h...t......o..HPs.ppRlt...........................................................................................................................	1	1028	2092	2791
+3754	PF03571	Peptidase_M49		Peptidase family M49	Griffiths-Jones SR	anon	MEROPS	Family	\N	19.10	19.10	19.20	19.20	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	551	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.95	0.70	-6.44	27	706	2009-09-11 00:19:35	2003-04-07 12:59:11	10	9	421	5	366	722	86	347.00	24	67.47	CHANGED	spl.appspch............lYshcsptt..LGa.spsshosYYs..........sslocp-h-hls.chhpspsl...s.NTRlhK....sucs......aplhlASsppsppst.h..............phpGpp..lplshGDast.hp+lsppLcpAppaAAN-sQpcMLctYlcpFpoGshpsHKcuQ+hWlKDhuPhVET.IGFIETYRDPtGlRuEaEGFVAhVNK-pot+FspLVssApphlphLPWsps..........aEKDpFh.PDFTSL-VLoFuuSGlPuGINIPNYDDlRps.GFKNVSLGNVLuusspspp.....lsFls-cDpclapKapspuFEVQVGLHELLGHGoGKLhpcstsGpaNFDhps..ls.lssc..l...soaYcsGETWsShFGsluuuaEECRAEsVulYLshpc..-lLcIFGhpssp.....-tccllassaLpMlcuGL.huLEaasPcsc....KWsQAHhQARFsIl+slLc..tspshlclppsp.sp...hsslplclD+S+I..osG+pAlpcaLt+LplYKSTu-hcsGpchaschosVs-p....ahchR-lVlt..+KpPR+halQuNThlss........spVp.lh-Y-po.tGhIpSalER..	...............................................................................................t.............................................................................................................................................................................h.h........G...a.t..htphs..lppAtt...hutsttptthlt.hhp.atpGs.ptacp.phhWl.pphss.l-.......GFhEsYtDP.h.G.h+.upaEu.hlth.....hs........t.ottht.hs..tput.h....Phs.t..............ac+..p..h.....t..s..shpslps..h...h..h...uu.....s..........h.....P....h....GI.....NlP...............N.........p.lRtp.G.Ks..VpltNlhtsh..t...........h.l.p.....t.....t..p......th.h..p.h.t....s..lp...sshHEh.hGHGsGpl......................................................................................................................................................................................................................................................................................................................................................................................s....................................................................................................................................................	1	147	232	311
+3755	PF02868	Peptidase_M4_C		Thermolysin metallopeptidase, alpha-helical domain	Bateman A, Griffiths-Jones SR	anon	Psiblast P06142	Domain	\N	24.40	24.40	24.70	24.40	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.14	0.71	-4.50	113	1990	2012-10-03 04:41:15	2003-04-07 12:59:11	10	77	1088	114	328	1719	59	152.70	37	28.88	CHANGED	usLhYpspSGALNEuhSDlhGshlc.ahttt.........t......t..........DWllG--lhp........t...G..suLRpMssPsps.........sspssphs........sh.....................tD.....sssVHhNSGlhN+AFYLlupu...........................hsGhuhcKAtcIaYcAhsh.YhTsso....sFspu+suslpAApDL...aGttu..tphpsVpsAassVGV	...........................................usL.YpspSGALNEuhSD...lhGhhlc.a..tt...................t...............sWhlG-.-lht.................t.u....suLRsMpsPsp.................tsps..schsca..................................ttDsGGVHhNSGI.N+AhYLlupu.............................t.u.l.GpcKs....tpIaYpA.s....Y....ho...s..so....sF.......pps...+suslpuA..p..-L........YG........s.......tpspsVtpAassVGl...............................................	0	104	192	278
+3756	PF04951	Peptidase_M55		D-aminopeptidase	Bateman A, Rawlings ND	anon	COG2362	Family	Bacillus subtilis DppA is a binuclear zinc-dependent, D-specific aminopeptidase. The structure reveals that DppA is a new example of a 'self-compartmentalising protease', a family of proteolytic complexes. Proteasomes are the most extensively studied representatives of this family. The DppA enzyme is composed of identical 30 kDa subunits organised in a decamer with 52 point-group symmetry. A 20 A wide channel runs through the complex, giving access to a central chamber holding the active sites. The structure shows DppA to be a prototype of a new family of metalloaminopeptidases characterised by the SXDXEG key sequence [1]. The only known substrates are D-ala-D-ala and D-ala-gly-gly.	25.00	25.00	33.80	31.10	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.55	0.70	-5.18	41	469	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	424	5	164	444	48	259.60	34	95.97	CHANGED	MKlaISsDhEGlsGlsshpplps.......usspYp+uRclMTp.......EsNssl-uAhpuGA....s-VlVNDSHusMsNL...lh-clcs.....cspL.lpG.ps+shuMhpGl.-puhDushFlGYHu+AGs.p.GlhuHThsutshpplhlNGptlG.EhslNAhlAGtaGVPVsLluGDDh.htpEs..cthhP.ssphlslKcuhu+huuhshosppspptl+puscpAl..cptpph.....pshphssPsplclchpssuhA-hsshhPslERl-usT.Vcapupshh-shpshpsl	........................................MKlaISsDhEGluGls.s.hppsps..........sst..c.Y.pcsRchMTp.......-ssAslcGshp.u.G.u.......sEllVsDSHus.....hp.NL...hh-p...l.ct.....Rspl.l..pG..ps+.shuMhpGl....-.p.u.hDulhFlGYHAtA.G.s.c.GlLuHThsusshtplhlNGhthu.EsslNAthAuchGVPVsLloGD-s.h.tc-s...cthhP...psthVs..lKculu.p........huuhshsPppspptIptusppAl..ppttph................tshp.h.s.....s.PhplclphpssshA-.hhshhPslc..Rl-..u.pT..Vpapupshhcshphh.s..............................	0	54	107	134
+3757	PF02031	Peptidase_M7		Streptomyces extracellular neutral proteinase (M7) family	Mian N, Bateman A	anon	IPR000013	Domain	\N	25.00	25.00	26.20	25.30	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.66	0.71	-4.44	4	82	2012-10-03 04:41:15	2003-04-07 12:59:11	11	2	55	2	34	84	5	131.00	48	61.41	CHANGED	AVTVsYsASsAPSFpoQIApusQIWNSSVSNVRLptGSs.ADFoYhEGNDsRGSYASTDGHGRGYIFLDYpQNQQYDSTRVTAHETGHVLGLPDHYSGPCSELMSGGGPGPSCTNsYPNSsERSRVNQLWANG	...........sTlhYsuSpAssFcutIspustIWNuS..VsNV+Lt..p.u.os...Achs.h.h.t..s.s.cspu.ohAsssGt...GpG.hIaLs.h.p.t.s.Q.t.YssTR...lsAHEhGHlLGLPDpYsG.PCSpLMSGuusGsSCTNshPsAsE+uRVpphaA.G.............	0	11	25	33
+3758	PF01457	Peptidase_M8		Leishmanolysin	Bateman A	anon	Prodom_3085 (release 99.1)	Family	\N	19.30	19.30	19.30	19.30	19.20	19.10	hmmbuild  --amino -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.83	0.70	-6.16	8	1086	2012-10-03 04:41:15	2003-04-07 12:59:11	11	33	163	1	602	1111	26	328.90	21	71.05	CHANGED	H+CIHDtLQARVlQSVAtQ+hsPuuVSAlGLPYVosssh...tpAsssDauhusuoo..VsRAAsWGsLRIsVSsEDLTDPuYHCupVGQplsNHtGslssCTAEDILT-EKRDILVpaLlPQALQLHs-R.LKV+QVQGcWKVTGMssslCucFKVPssHlTs.....GVoNTDFVLYVASVPSE.....uVLAWAsTCQVFuD.G+PAVGVINIPAAsIsSR..YDQlsTRVVsHElAHALGFSs...sFFcss.GIlppVoslRGKsa.................................sVPVINSsTVVAKAREQYGCsoLEYLElEDQGGuGosGSHlKhRNApDELMAPsuu..AGYYoALTMAlFpDLGFYpAcFopAEsMPWG+ssGCsFLocKC....MEcNITpWPuM.FCN.......copsshR..CPTsRLsLGoCslssYpssLPsYaQYFT.........sssLGG.SsFhDYCPallsau..........sGuCsQcsSsAsshhctFNVFS-AuRClDG..sFpPKsssu..hls.YsuLCANVpCDTAs+TYSVQVhGuoGYssCTPGtR.lcLuTVSsAFpcGGYITCPPYVEVCQuN	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t......t........sDh..hhhh.......................................hu..A.h..C..............................................+.....PhhG..h...h.....p.....h.......s..............t........h............................t................................h......t.....h......hh......HEhhHsL.........G.Fs................hh...t.............................................t.......................h...........t..t.....................................................................................h.hl......o.s.p......sh.t..h..s...+pha.........s.........C.....s.........h.........p.........t........hp.lE..s.........t..G...u...t....u....o....h.h.o.....Hhct.+...................h..sEhM.s.....s................................s.......ts.........h...h.........ot...h...T...hAh.h...p.....Dh.....G...a.Y.p..s..s....h..s....h..s..p....h....................WGpt...uCt...h..h...t.t.C........................................................as......................................C.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	425	463	569
+3759	PF01752	Peptidase_M9		Collagenase	Bateman A	anon	SWISS-PROT	Family	This family of enzymes break down collagens.	22.10	22.10	24.70	27.80	19.40	17.40	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.98	0.70	-5.51	7	608	2012-10-03 04:41:15	2003-04-07 12:59:11	12	12	306	3	82	554	4	282.40	35	35.67	CHANGED	hpplhtth.hG....uppDplWLuss-hhpYYA..shpt.s..lsttpt-LAt+lhP.pa.CpssuhIcupphosupsApuCclhtsK-ttFHpshpsspsPVtDDtssplcVslFsssssYhpY.hah.......FspsTsNGG.YLEGNPuchsN.spFlAYchtphs.Dl.lhNLpHEYsHYLDuRFspYGoFscshtcuphlWW.EGhAEYhHYpQG...hpAAhphhspG.chsLSslhsTT...a......SpDosRIYRWGYLAVRaMhE.pHspDspohLshoR.G.pas.au.tsthhs.hYss-athW	........................................ppl.phs.ls....ssp.cs...hWLhss.ulaYsuph..uphc.s.shs..thhp.Ah+hhPhhtpp.hhsAh.phps...hsupstsu.sslshpc.cc.t+pthh.s+s......shD.Dsshsl+sushsoc-ch++L.haA......pFt.psssNst.h.cGNPsDlh...shshasu.-..c..a..p.h....N....c.....hhh..scphshYl-u.h...spahoacR.T.s.c.p............S...............h...............hsh.p.hhtEas..HYhQG....pht...ssu.lh.....up.....G....c....h....h....s-..hhshh.pt.......usc.osplh.ht.lh..sth...-.....t....p...p.ssphhhh.u+h.G......pa-hYshths.h.u..hYsppapha...................................	0	22	36	62
+3760	PF00768	Peptidase_S11		D-alanyl-D-alanine carboxypeptidase	Bateman A	anon	Pfam-B_864 (release 2.1)	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.57	0.70	-5.10	12	8726	2012-10-02 21:13:33	2003-04-07 12:59:11	15	33	3497	44	1522	7430	2600	235.10	31	61.21	CHANGED	sspssstP.........plsApuullhDhsoG+lLYppsscphhs.ASlTKlMTuhlVhcAhpttplc.sshVslupssathst....tsSphhLc.spploV+-LlpulhlsSuNcAslALA-hluGup......csFVchMNstAcpLGl+NT+F.sspGLsscs...............hSoApDhAlluptll+t.h.pphphspcpphsFp..........phshhNpNtLlhpps..lDGhKTGaTstAGasLVuoAscs.shRlIuVVhsAps	.........................................................h............pl.sA.p...u.h.l.l.h.Dh...s...oG.....c...l....L....h........pp.....N....s.c.p.thsPASlTKlMT.uhllhcul.....p.t.....t.......p......l..................s..h......s...s...h..V..s....l.o.p...p.u...h.t.t.s...................sS...ph.h.l.c....s...G.p.p.lolc-LlpuhllpSuNDAulALA....-....t....l....u.....G..o.p.....................................p..sF.l..ph.M.Np.p.A.c.p.LG.h..p....s.....T.+.F.h....s........s..s........G.L.....s....s..s..s.t....................................hooA.cDhAllu.pthl.....c.....p......h....s...p...........h....s....h.....t...p....p..p.p...h...s...a.s..............................shp.h.h.....N......p......N.....t.........L...l..........h............p......t.......s.............................s................l....D....G...h.....KTG...a.T.stAG..as..L.lu......o.......A......p.......c.......s.......s.......h......R..l..I.s.VVhsu..s..................................................................................................	1	486	949	1228
+3761	PF02113	Peptidase_S13		D-Ala-D-Ala carboxypeptidase 3 (S13) family	Mian N, Bateman A	anon	IPR000667	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.31	0.70	-5.98	9	2907	2012-10-02 21:13:33	2003-04-07 12:59:11	10	7	1969	75	742	2721	1248	317.50	25	88.36	CHANGED	LstslsshltD.PpL.Gu.sGlhlpcssoup.lapapusp.hlPASstKLlTAsAALhsLGssacFoTcVhssG....tshpGsLhlhGuGDPTLssps............lsslscp....L+cuGVpsl.phslhlDsSlFsu.shusuW..sD.s.sasuP.sushl......DsGph.splss..t.Gp....p.ss...h...t......ttusts.........hs.pphhlpGsls.t...h..shsVpssuthAuchhpcpLtttGlphsuslshssss...puupsLAstpSsPL.clLppMhKpSDNhhAEslh+tluhsh.ptPuoapsussuVpptL.sphGlDssshhLtDGSGLSRpshloucTlsplLpshs..ppsshpshlssLPlAGts.....GTLpsRht....spsssGhl+AKTGoLouV.uLuGa..........lpspsGchlsFuhl.N...hsstsspshcsshsthtspl	.....................................................................................................t.....huh.l.p.ht.....s..s....t....h..h...t.h..p..sp....h..PASs.Klh.Tsh..A.Ah.........L....s.s..s..ap..h....p....Tp.l...........h.................p.s.....................................tu..........sl...hh.h.hsuDP..h..htt...tp....................................h.....t..h.h.tt...................l.p......t.....t........G...l...p.....p.....l...............p.l..h...h...Dt..oh....a.........t...........t.....h..s.......s...........h...........t..s..............................s........tsh.h..............s.shh......................................................................................................................................................................................................................................................................................................................................p....t...h.hthh.t.ht.t....s....h.t....h...................s........t........h......h.......t...........t..s..................t...sp..........l...s...t....h..........p..S....s..l........p..llp.h.p.SsNhhA-tl..h....h..l.............u..................h.....................t..............................s...........s.......h........t......t..u.....t...s.........l......p.p.hl....t......p..h..G.l...s...h...s.......s.......h.......h..h..D.GS.....GL.....S....pt.......shlsst..hhph.Lthhh.....................pp.........................h..h...p...l.P.lu.Ghs...............................G.olp......R.ht.......t....h..tu.ltsKTG.o.............L......p.....s...........l..........................sluGh..........hh....s.t...s.G.p...h.hhs...h.st..............................h...............................................................................	0	232	506	664
+3762	PF02129	Peptidase_S15		X-Pro dipeptidyl-peptidase (S15 family)	Mian N, Bateman A	anon	IPR000383 & Pfam-B_2704 (Release 7.5)	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.90	0.70	-4.98	48	2545	2012-10-03 11:45:05	2003-04-07 12:59:11	13	23	1647	54	719	8025	2907	265.50	22	43.65	CHANGED	DG..scLtsclhpP......psstslPsllptoPYt..tpp.hssshthtpst.....................................................asscGYssVh.-sRGptsS-Ghhsst..........s.pEspDstssI-Wlss..............p.sWssG+VGhhGhSYtGhhshtsAs...............sss.uL+slsstsu.....hsshas..hhhpsGshttsshhsh........................sshttthhupthsstphhpthht................htthhp.hhtchcpp.......................psshssaWpspsh...p....ph...stlcssslhspGhtD.shh.psshphapsLpsss......................+LhlushsHst	...............................................................................................................................DG...shlts..slhp....P...........s.............ts.......tp.hP.....s..l..h..p..t..s....P..Yt........ps....h.h.p...p.h..s..h..h..t.h...........................................................................................................................................................as.s..c..G..Y..ss...lh...s..s.....s......R.....G......s......t........p........S....p......G..h.h.ssh.............................shp..E..h.....p..D..s..h...s.l..I...-......W.l.ss............................................p...s...W......s......s...G.....p.....V.G.h..h..G.hS.Y.h.G....h..h.p..h....t..s...A..s...............................p..s..s..s.....s...L....c..s.....l...l...s..h...su.........h.s..s...h......Y...p..........h...h...h...p...s......G...h......ht....s......s...h..h..h...h..................................................................t...h...h....t...h..h........s...p....t.........t......t..h...h.t..............................................................t...htt..ptt...............................................p......s...t..h....s...p....a..W......p...p...t.sh.....................h....................ppl...p..ssshhstG...h.tD.shh..t..tsh.ph..a..p.tlttt..............................phhh.t.htHh.............................................................................................................................................................................	0	221	468	626
+3763	PF00716	Peptidase_S21		Assemblin (Peptidase family S21)	Bateman A	anon	Pfam-B_729 (release 2.1)	Family	\N	20.60	20.60	21.20	21.20	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.07	0.70	-5.10	11	192	2012-10-01 19:43:34	2003-04-07 12:59:11	12	2	89	47	0	212	0	280.20	30	49.47	CHANGED	ELhLs.-sVpptLPsss........slPlNI-HpssssVGpVlulhssppGlFhlGllsssphhslLppsupsuhhuppss...shh..-thL.hLosaLPuLSLSS++....husspts...-sshFpHVALCulGRRhGTlAlYups.-hslstFscLSsup+-tlhp....sppssu.............hhtsshps.spsLLusAlcshal+-RhshLppc+phAGIt.scoYLpASssh..tsssp.pssspph........................shpsss...........shsssps...............spshssssPsu......................ssssusustsh......tDhlhlPtspatpLlsupttsts....ss.sssthhhPsssss.sshP	.........pLhLs.-hVpthLssts.........slPlNlsHptss.VGtVhulhss..cG.FhlGhlsssphhpllppsuptshhsptss........................-.ll.hloshhPulSLSSh+................tstt.s......................stshFtHVuLCslGRRhGTlssYsts.-hslt.F.tpLo.sp+ttlht................stt.hs................ts.tsshps.shsLLusulsshhl+-Rhshlt.c+p.sGlt.tpoYlpASt......t.t.........tt...............................s.............................................................s.s..shhssh........................s..ssssssushs.s......t-hlalPtsta.pLls..upttst.s.....s..sts..h.P.......................................................................................................................................	0	0	0	0
+3764	PF00717	Peptidase_S24		Peptidase S24-like	Bateman A, Finn RD	anon	Pfam-B_616 (release 2.1)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.42	0.72	-4.33	228	17337	2012-10-02 16:34:55	2003-04-07 12:59:11	18	67	5051	47	3901	12330	5963	72.80	24	32.79	CHANGED	pVpGcSM....t..sslh.sGDhllVc...pts........................psppG-..lVlh..phssp.............shlKRlh..thsssthh..................hsslhlssp	..........................................................l.GsSM...............p.s.s......l.........h......s..........G.........D.h..l.l...V.c...........+ts..................................................................psppGD..lV..lh.........phssp.....................................shlKRlh......th....s...s...c...h...h.h....................t.l.h......................................................................................................	0	1246	2442	3261
+3767	PF03572	Peptidase_S41	Peptidase_S41;	Peptidase family S41	Griffiths-Jones SR, Finn RD	anon	MEROPS	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-11.05	0.71	-4.84	142	9366	2012-10-02 13:07:06	2003-04-07 12:59:11	13	89	5410	38	2078	8432	3390	171.70	27	34.34	CHANGED	plGYl+lssF..t............tsspphpptlpcLpp......pshculllDLRsNs.......GGhlstulplsshals.......sssll.pp....sptsppp......................................................t.t.t....................hstPllVLlspsoASAoEIhA.uAlp-tpRu..hllGpp.TaGKGslQshhpL....ss............ssslp...lThu+ahsPsGps.lpth...GlpPDltl	..........................................................................................................plGYl+l.s.s.a..tt...........................................tsstt.lp.p..hh.pp.Lt...................sspul.l.lDL.RpNs.............G.G.h...l..s.t.s.s..t..l.s.s.hhhs........sssl..h....p..h......sph.hs.pt...........................................................................................................p.hs...sp.h.........................................................h.tsts.llVL.sstt.ou...Su....uEhlA..tsL..p......c......h.....p..RA......hl.l...G...cp...Th.....G.....t.....u..h.....s...p.p...h..h.pl.............ss................................s.h.h.lp.......ls.h.u.+..h...h..s...P...p.G..ts...hpth..........GlhPsl......................................................................................................................................................................	0	802	1448	1814
+3768	PF03574	Peptidase_S48		Peptidase family S48	Griffiths-Jones SR	anon	MEROPS	Family	\N	21.50	21.50	22.20	31.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.86	0.71	-4.20	4	138	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	109	4	5	124	0	146.60	84	79.25	CHANGED	YlEQGQNLRMTGHLHHIEPKRVKVIVEEVRQALTEGKLLKMLGSQEPRYLIQFPYVWLEpYPWpPGRsRIsGsSLTs-EKphIEsKLPusLPDApLINSFQFMELIEFLH+RSQEDLspE+RMsLSEALAEHIKRRLlYSGTVT+lDsP	.YLEQGQNLRMTGHLHHLEPKRVKlIVEEVRQALTEGKLLKMLGSQEPRYLIQhPYVWhEKYPWpPGRSRlPGTSLToEEK+QIEpKLP.....sNLPDApLloSFEFLELIEFLHKRSQEDLPscHQMPLSEALAEHIKRRLLYSGTVTRIDSP.	0	0	4	5
+3769	PF03575	Peptidase_S51		Peptidase family S51	Griffiths-Jones SR	anon	MEROPS	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.95	0.71	-4.48	24	2034	2012-10-03 00:28:14	2003-04-07 12:59:11	12	9	1732	6	487	2189	1077	152.20	25	62.84	CHANGED	Yhpphtpshpp.LG......ht.lssLchst........-hpstlppsDhlaVGGGNTFpLLptlpcpsLsphlpctl.ppG.hsYhGhSAGu......hl.....s.s.oIpsss...hs.h....p..sa...p.u......LsLlsatls.PHa...sstp.t.....E...shtpplppa...psh.slluls-GsAlhlpscp	.........................................................hhtsht..lG......hp....lph.lc.hhs...............c..ht.tl...p...pA..-....hlhluG.G.N.oh.p....Ll.....pph......c.....c.....p.....s.....lhp......hlp...c.hl....p......pG...slhh..Gh.SAGA.......................l..................h..ss...s.l.t.s.s.s......p.h.s.s...................p.tsh.........s...u.....................................L.sL..h.s.....h.....t......ls..PHa.....sst..p.............p...shppclpph............t.s...p.......h..s.h.luls-s.sslhlptt.p..............................................................................................	0	177	325	427
+3770	PF03576	Peptidase_S58	Peptidase_T4;	Peptidase family S58 	Griffiths-Jones SR	anon	MEROPS	Family	\N	22.20	22.20	22.70	23.00	21.10	22.10	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.01	0.70	-5.25	108	1255	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	969	47	448	1181	478	314.80	32	91.85	CHANGED	hNuITDVsGVpVGHsTl.ttt......................sl+TGVTsIlP+.ts..ppsssAusaVhNGsGc.spGhshlcEhGhlps..PIsLTNThulGh.sssullphhhst..s..........hshshPlVsEs.DuhLNDItuttlp..........tpcshpAlsu.A..................tsss.......hspGuVGAGTGMhshshKGGlGoASRllst...........uaTVGALVtuNa.Gph.....tphhl.uGh.lG.pchushs.s.........................................................................tpGSlIsllATDAPLsspQhpRLApRAtsGlARsG..ustssuSGDlslAFSTusps.tstst................l.pt...ls.LapAAupusEcAIhsulhsAps.hsG...t..pscth.ul	.........................................................................................h.ssITDVsGlpVGHtoh..p........................thtTGlTVlls.....................ppsssAulcVhsGsst.optsshlc.hshlpp...sllLosspuhGh.uusGlhchhhcp.....sh......t.hpssssssPlVst...u.hL.....Dlt.stssp..................................tphuhtA.hps.A.........................t.s.s..........hs..pGs.VGA.Gs.....Gh.......s.......s.........h.....s.......h................K.......G.......G.....l......G.o...A.....Sth.lss......................shsVGALVhsNh..Gsh....................tthhh...ssh.....su......t..h..tt.h......s..................................................................................................ttsstsosIsll.ATDAsLsptQhpRlAttApsGlARsh..ssas.hsGDhhhAhoTupths...t.............................................lsslhtAAA-shpcAllpulhtAps.h.u.........h............................................	0	134	269	374
+3771	PF00082	Peptidase_S8	subtilase; 	Subtilase family	Eddy SR, Sonnhammer ELL	anon	Overington	Domain	Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see Pfam:PF00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null --hand HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.35	0.70	-5.26	63	15113	2010-07-03 07:17:22	2003-04-07 12:59:11	17	580	3631	324	6420	14631	3376	299.50	19	44.44	CHANGED	slullD.oGlp.....ssHs-lp......................................sph........t...ua.........................................................................................shssss.......................p.ttstss............................HGT+sAGhluuss...tss.s..hGVAhsuplh...............ul+l...lssst..ssss......................hhpulphss.................pph.clhshSh.Gs............................t.....psshhptsh.........p......stsspGtlhVhAuGN......ssssss.....................sssPuhh........psh..loVGuss......................................................................................................................................pp.................s.....ph....s.aSsh.........s............sss........clsusGs..sh..........ssh...sssp..................tshtthsGTSh.........AuPtsuGhhAllhp....t.Pph...............ospplpt.hllpoAp.hs...........................hsphh......GaGl..lshtpslp	................................................................................................................................................................................................................................................................................lsllD.oG....l...............p.p......p.ht............................................................................................................th..................................t...h....................................................................................................................................................................................................................................................................................................................................................................................s.h....ttt....................................................s.t.ts............................................................................HGT..ps.A.u......h.......l.....uu..........t.................t................................................................t........................h..................G........l........A............p.....u...p.lh..........................................sh.+h............hssts.....sptts.....................................................lht.u.lphsh.................................................................pps.sp..l..l..s...h...Sh...Gs....................................................................................................................t..t...h.....h....p..t...sh........................p.................ts.h..p..p..G.....h..h.h..l..s..A......A..GN..........................s.u....s.s.st..........................................................................................................................................hs...P..uth................sss.......lsV..uu...s..s...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pp...............................................s..............th...............utaSsh.............................u................................................................s.h.............................-..l...s....A.....P....Gs...sl......................hush.........ssst.....................................................................................................................................................ht.hhsG.TS..h...................................A.s.P..hl..u.....G.hs.A.Ll.hp.................t..s.ph..........................................s.st.t....l.....pt....h....lh..p..s.....u..t...............................................................................................u.G............t............................................................................................................................................................................................................................	0	2244	4178	5504
+3772	PF00326	Peptidase_S9	Prolyl_oligopep;	Prolyl oligopeptidase family	Finn RD	anon	Prosite	Family	\N	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.29	0.70	-5.12	70	9052	2012-10-03 11:45:05	2003-04-07 12:59:11	16	114	3171	311	3615	20889	7745	202.90	21	30.52	CHANGED	ssF......s..tphthh..............spGhlhshsshRGuuthGcpatcss.ptphtpsshsDhlsuscaL......hppt..assss+lulhGuSsGGhhsusshs.tpschF+sulutsshsDhlphhtts......hst.pa.caGss.p..stchYpthsshsshcshh..........thsshLlhpGhpDsRV.h.tcuh+hhstLp.........ppGss.hhhth.ssuGH...ustpsptph.cthtphhuFhhpthshp	..................................................................................................................................................................h..h......pp.G.hh.hhh..s....s.....h.....R....G.............u....s...........t.............h.......G...........p...t................a........h................p.......s...........h.......h.......t.........p.......h......t.......t........t......s.....h......p......D....h...h....s.....s...s...c..h..l.............................hp..p....s.....h....s...c...s....s.....+...l..ul.h...........G..t.S.h...G....G.....h...h.....s.........s............h..............s.............h.............s......t..............t..............s...........c..............h.................F................p...............u............s..........l............u......t..............s.........s...........l...........s.....D........h.....h.........t.........h....h....t.....t.................................hs.t.........p.....h.........p.........h.......s............s.........s......p..................s...p...h...a....p....t....h.......s........s..h...s.......h.c.p......................................hts.s..l......L...l...h..p..G..t...p..D....s...p.....V.......h....t.p...u....h...p..hh.s...t.Lp........................ptst..s...h..t.h.........h.........h.h.........s..t....s..H.............u.h....t....p...s....p...t...p....h.......p....h.......h.t.thh..t..ah.phh...h................................................................................................................................................................	0	1280	2250	3034
+3773	PF03418	Peptidase_A25	Peptidase_U3; Peptidase_M63; 	Germination protease	Bateman A	anon	MEROPS	Family	\N	19.70	19.70	19.80	19.70	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.11	0.70	-5.72	2	602	2012-10-01 20:58:29	2003-04-07 12:59:11	9	2	413	2	149	477	6	219.30	31	94.65	CHANGED	AVEsK-hhhppQshPsp..EIKGhI.KE+-ctGlKIphV-lTcEGAEh.GKKcGRYlTLEu.GIREpDoEhQEthptVFAcEhshFlcsLNIscDASCLlVGLGNhsVTPDALGPhAV-NLLlTRHLFcLQPEsVQ-GaRPVSAhsPGVMGhTGIETSDIIhGVlcpspPDFlIAIDALAARulERVNsTIQISDoGIHPGSGVGNKRK-lSh-TLGlPVIAIGlPTVVDAVoIsSDTlDaILKHFGREMK-p.+PS+SLlPuGMTFGcKKhLTEDDLPspcQRQoaLGhlGTL.--EKRpLIHEVLuPLGHNLMVTPKEVD.FI-DMANVlAsGLNsALHccVsQENhGuYsH	...................................................................................Gh....p..p.....t.....t..t..hhl.s...lp.l.......p...s.t.p.....h.sK...GpYlTl-h..t....h.t..s.th.pph.t.hsp.ht.h..............................p.......ph...LllGLGNhplTsDuLGPhshpplhlTRHl.h.p......s..p.....h.....t..t.h.p...l.sultPGVhu.TGhEos-ll.ullpphpPchllslDALAuRphpRlspoIQlssoGIpPGuGlGNpR.tlspcslGlsVlulGlPTVlpAsslsp-shp..h..................................................................................................................................................................	2	82	127	135
+3774	PF01136	Peptidase_U32		Peptidase family U32	Finn RD, Bateman A	anon	Prosite	Family	\N	21.30	21.30	21.30	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.49	0.70	-5.43	166	7851	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	3207	0	1379	4878	390	231.70	27	57.79	CHANGED	lppltchlp..h.h.......................phtsDu...lIlsDhGllphhcct.splslHsSsphsltNhpslphhpch...GhpRlVLuREL...olcclpp...ltp..ps...........s...lElElFlHGul...........CluaSG+ChhSph.htsps...................sN.+GpCs.psCRh.sat....................................hhppt.pstp..................................ahhSspD.l..shlpplscLhcsG.lsulKIEGRh+s..tYls.plspsYRpslDsh.tt.............t.t..phhppLpph..hpR.......shssGahhspsst	........................................................h...h.chlc..l.h.......................p.hGsDA....lIhu...D.Gl......lt.....h....s.......p....c.......p......h......P......p...l........t......l..HhS..sQssss..Nhtslc.aa.pch...G..........h.p...RlVLuREL.....ohcpltp...............lpp....ps.......................s.h..-lElFla....Guh............Clu..aS..GRChlSsa..hst.+s...................sN...pGs..C..s..psCRh...pap....................................................................lh-pt...pst..c.t.....hsh....t.....p..Gp.........................................................ahhsspD....l....shlpplscL.hc.t.G..lcSlKIE..GR.h+s..tYls.plspsYRpAlDthhts..........................p..thhpp.ltph........hpR.......shssuah.tp...p...............................................................................................................	0	454	880	1149
+3775	PF03577	Peptidase_C69	Peptidase_U34; 	Peptidase family C69	Griffiths-Jones SR	anon	MEROPS	Family	\N	20.70	20.70	21.10	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.26	0.70	-5.60	13	1802	2012-10-03 21:14:07	2003-04-07 12:59:11	10	11	864	0	402	1558	66	354.50	29	76.08	CHANGED	ACTTlLVGKpAShDGSThIARsED....tsushsPK+alVlps...ccQP+c.Y+Slhoshph...cLP-sPhpYTSsPsu....sspc.GIWuEAGlNpsNVAMSATETITsNpRlLGsDPhV..................psGIGEEDhlTllLPYlpSAREGVcRLGpllEcYGTY.EuNGlAFSDpcEIWaLETlG......GHHWlAtRlPDDsYsssPNQhsIDcFDhsDs....-sYhsSsDLc-FlcppHLs.shp......................tcFNhRcAFG.opscKDppYNsPRsWhhQ+aLs........P-hc..psPcspclPahp+...PpRKlolEDlKalLSsHYpsT.....saDPYGs..pGstpsccta.........R......PIGlNRoppsalLQlRsslPptluGVpWLuaGsssFsshVPFYssVscTPstap..cTsschoss..shYWts+hlAsLuDscYptassslcsa.cp	..........................................................................................................................uCTsllVGKpAohDGSshluRs-D.................t.h.sp.phhhh.s......t.p..t..t.t......h......h....s...................s....t..h.....ph..........l.P.....t.....p...s...h.....p....Y.ss....h.ssh...........................t.p...Gh..h....s..p....s..G..hNp....t....s..V..u....h....o....u....T.co..h.h.s.Npp.s.h.u.h..D....P.h.l.......................psGl.sE.ps......hhslsLPhhcoAREGVphlGpLl-c..Y...G..................s...........h.....E..............u.............N........u.............l.......h............huD.p.s.E.lW.a.h.Ehhu..............GH......p......WsAtR...l.PD...DsY.ssh.sNphtI...p.p.h........D...h...s....c.....................pshhhSsslhpasccpth...s..sh.p.......................................................t.F.shppsau.....s....t....s.......t...c.....th..Y...s...psRsWhh.......phhs...................Pphp..............p.s..p......s..t....phPhhhp.....s.p.+.plol.pDlt..hh.psH.apsT.........a..D.s.hs.................t......pt.a.....................................R................sIuh...pstpstlhQl..R..s...t...h...P.tt..hs.sl.WhuhG..sshsshlPaa....ss....h..p..p....h..s..ap...................t.s..s.t......p...h...s.p...............shaWh.phlsshs..pat.hh...pth...t..........................................................................................................................................	0	123	214	291
+3776	PF03419	Peptidase_U4		Sporulation factor SpoIIGA 	Bateman A	anon	MEROPS	Family	\N	25.00	25.00	27.20	26.60	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.54	0.70	-5.34	34	409	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	402	0	90	356	5	271.70	27	96.09	CHANGED	M...hlYlDllaL.NhlhshhLLhlTAthl+ppsphhRllhGuhlGuhhsllhhh.P......hhshhhphhhKllhShlhlhhuFuhcphth............hl+slhhFYhsoFlhuGuhhuhphhhptshhhpsthh.h........hsahhllluhsshahhh+thhchlpp+phptphlhcVplthsspphpl+uLlDTGNpLpDPlTptPVhlV-hstlcpl.hs.ph..........slpphtph....t....p+hRlIPY+ulGp.ppGhLhuhKPDplhI.pppchlpspcsllulspppLSspscYpullpPcll	............................lYhDlhhl.NhhhshhlLhhouhhh+t.phphhRllluAhlGuh.hslhhhh..P....................h.hs.h.h.h..p....hh...K.l..lhSllh.lhhuFshpsh+p....................ahpslhsFYhsoFhlGGshhuhphh..hps.st.h.h..shhh.............hs.hh..h.llhuhs..lh.a.hhh.c.thhc.l.c.p.p.p.hpts.lhclclpls.p..c.....p....lplpuLlDoGNpLhDPlTppPVhlhchss.lcph.hst.h...h........t.........ph...p.h..p............hhp+l..RlIPa+uVGt.ppthLhul+PDplpl.pps.p.p.hhhpcsllulssp.pLSspscYpsllpPphl.........................................	0	47	75	80
+3777	PF03411	Peptidase_M74	Peptidase_U6; 	Penicillin-insensitive murein endopeptidase	Bateman A	anon	Bateman A	Family	\N	20.30	20.30	20.40	20.80	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.57	0.70	-5.14	3	916	2012-10-02 01:02:30	2003-04-07 12:59:11	8	8	890	8	146	530	97	237.60	59	82.86	CHANGED	QSIGSYoNGCIlGAsALPscGEsYQVMRhsRNRYaGHPcMItaLERLSpcAussGhPTlLVGDIuMPuGGRFLTGHASHQsGLDADIWLp.MPKpRaTsApppcspALslVcRDup+VDs+lWsPs+soLIKLAAQDP-VTRIFVNPAIKpQLCpTAGsDRuWL+KVRPWaGHpuHFHVRLTCPADSsECEsQPhVPuGDGCGcELtSWF..EPPKPG..ToKPcKKssP....PLPhuCQAlLNuPsh	..........................QSIGSauNGCIlGAssLPl............pu-s...Y...QVMR..o..cpcR..YaGHPDLlh.F.I.QR.L..Sp......p.s.p..p.h..G.h.G.T.l.L.IGDMuMPuGGRF..suGHASHQoGLDVD.I.aLp......LP.K..p....R.a.o....s......A....Q..L...h.....c.P...p.A..lc.L......V.s......+......D......G....+....+V..l.s.shWpsphh.u......LIKLAApDp..-VT..RIFVNPAIKpQL...C.h...-.....A.......G.s.D.....R..........s.....WL....RK.........V........R.P..W..F....t.................H+uHMHVRL+CP.As.Sh.ECE-QshP.....Ps.....GDGC.G.A.E...L...pSWF...............-P....P.K..Pu......os.K..P....c.K.K.s.P..P................PLPPuCQALLcp.s.h............................................	1	31	69	105
+3778	PF01343	Peptidase_S49	Peptidase_U7; 	Peptidase family S49	Bateman A	anon	Pfam-B_707 (release 2.1)	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.46	0.71	-4.44	20	6794	2012-10-02 13:07:06	2003-04-07 12:59:11	13	22	2890	24	1513	5321	2903	149.70	26	46.31	CHANGED	pthcptKPVlshssshuASGuYalAosA-+IlusssullGSIGVhhphsshpshlcKlGlshpslpsGpaKsss..ohhcshos-t+phhQphl-psaphFlppVAcsRslsssplcplApG..clapGppAhcsGLVDElGsh--Alsphtp.hspls	...............................................t..tptsKPlh.ssh....s....s...hu....A....S....G....u....Y..hlA.s.s.A....s...c...I.h.s..s..P..s..u..l..l.G..S....I..GVh.s.t......h.....s....h.p.p............h.L.c.+.h.........G............l.chc.........hhp...s...G..p..aKssh...........shhpshos.c...s.+..p.thp.p.h.l..sp.ha.ptFlp.hV....u....p...sR..............t......h....s.........h........p.......p.......l........p........p........l...A...pG.........cha.......p......G.......p......p.......A......h......p...h......GLlD......pl...u.s.h.cc.s.l.tthtp..........................................................	1	508	959	1257
+3779	PF03420	Peptidase_U9		Prohead core protein protease	Bateman A	anon	MEROPS	Family	\N	22.00	22.00	22.10	39.20	20.00	21.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.40	0.70	-5.07	2	91	2012-10-01 19:43:34	2003-04-07 12:59:11	8	1	86	0	6	81	1485	196.80	38	87.65	CHANGED	.E.QLLIEsWG.su.hhsts...PhlEu+.st-hGhc..LYIEGIFMQupVVNRNtRhYPK+lhEpAVpcYIpEQVhTpQALGELNHPsRuNVDPhpAAIhIp-hWWcGssVhG+AhVlpss+..Gphltu.IcuGWlPGVSSRGLGSlpps.-Ghp.Vp-.F+LTVGVDsVWGPSAPsAaVpP..lTES.......pTtEhspSsDstahtLAEshKphL	................................t...............................pppG.tK..ha.IEGIFhQu-lhNRNtRhYP.+plLp+sVsc.Y.pc..lp..sppALGELsHP...s.......ts.....s.........ls..psuhhIpcLhh..c..Gss...shG+A+l.l.-ssp..GchltuLlcu.Ghh.GVSSRGhGolp.cp..cGhslVp-sFhLssusDlVhsPSAPDAaVps..IhEu..p......................................................h.....................................................	0	3	5	6
+3780	PF03036	Perilipin	perilipin; 	Perilipin family	Griffiths-Jones SR	anon	Pfam-B_1154 (release 6.4)	Family	The perilipin family includes lipid droplet-associated protein  (perilipin) and adipose differentiation-related protein  (adipophilin).	28.20	28.20	28.60	28.50	27.70	28.10	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.30	0.70	-5.63	17	474	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	106	1	237	475	0	278.60	26	73.43	CHANGED	husstps...QpsVVsRVssLPLVSSThshVpssYsuTK-sHPhl+SVC-hAE+GVpolsosAhsuApPllp+LEPQIusuNchAC+GLD+lEcpLPlLppPs-plhups+th...........l.tsVsuAK-oVsp.loussshshuuspsus-hT+shhstsh..VhuoRhsphsosuVDssLspSEclVDpaLP.o.-cELts.upp........................scu.-sssh....t.psuYaVRLGuLSs+lRcRshppols+l+pu+ppsQEtltQLppshsLlc.sppshp...pphhtt.tphh.hWhphppst.pst..............tp.pplEtcslslsRslT.............ppLQosshslsuSlpGLPsslp-pstplpptsttl.tshtshtshpc...ls.thLspu+tpltphptsLDplh-hllsNs	...................................................................................h..........p.pslpRlhplPlVpushphhppsY..ps...Kpp.s.h.lt.shphsEps...........l.......sh..A...h....t.s.Pl...l.p....p....lp.s....l...sh.ssphss+GLD+lEpplP..h..l..p..P....sp....p.........l......htp...h+th..................h..t.l...ps.......stssls..............hst...t..........th..........th............hh..t..s...h..h..phh.......t..sh-.s.....h.s...hs-.h..l..-.hl.P.s...pt-.t..st.p.....................................................................ps.p................phh.+lupLutphpp+shppshtplpth.p...t...pphh..l..sht.L.ht......................................................t................................p......h.tt............................tpl.thh..h....ht.hP...th....t.h.th..................h..........h......h..h.t.h.................................................................................................................................................................................	0	54	73	152
+3781	PF01497	Peripla_BP_2		Periplasmic binding protein	Bashton M, Bateman A	anon	Pfam-B_461 (release 4.0)	Domain	This family includes bacterial periplasmic binding proteins.  Several of which are involved in iron transport.	27.50	27.50	27.50	27.50	27.30	27.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.16	0.70	-11.13	0.70	-5.24	33	15783	2012-10-03 15:23:08	2003-04-07 12:59:11	13	38	3934	62	3407	11094	1155	233.80	16	72.71	CHANGED	lsshshssspllhtL...Ghtsplsussstspt.htttt...............sh.........spssstpphsh...................EplhslcPDlllssphh..........sph.chhptthsslshsssp.....................pshhctlptluphhspp..ccAcphhpphppplspsppphssh....ptpshhlhhhttt....thhhhhussshhsplhct.huhpsh.hstt.......tpttt.luhEplhs..hssDhllhtsp.....................pppshctlhps....sthppl.sAl+ss+lhthssph	................................................................................................................................hsht.t.h.chhhtl...............s.h..t...s.........h....s....u.......h....s....t............s...p.........................................................ph.............................................p..l....u...s...h....t...p...s..sh.........................................................Et.l......h..s.......l......c........P..D.....L.l...l...s.sstt.......................tt.th.....p..h.....h..p.....t....h....h......P...s...l....h...h...s..h.s.p..................................psht.p.p...l.p....p....l.u....p.hh...spp............c.c..A..c...p.....h....l....p....p....h...c......p..p...l...s...p..h....p...p.phtst...............ttp.s.h.h...h..h...h..h.tss.............................t..h.h..s...h....s...s..p.....s.....h...h...s...p..l..l..pt....hG.....h...p.....s..s...hss...............................ttsh.h..p...l..o..h...E..p...l...hp........hs....P..D.h..l..h.lhst............................t.t..t.t...h...p...t....l....h...p.s...................s.h...h...p.ph..sAl.+ssclh.h....t.....................................................................................	0	1003	2187	2887
+3782	PF00532	Peripla_BP_1	periplasmic_binding_like; 	Periplasmic binding proteins and sugar binding domain of LacI family	Bateman A, Griffiths-Jones SR	anon	MRC-LMB Genome group	Domain	This family includes the periplasmic binding proteins, and the LacI  family transcriptional regulators. The periplasmic binding  proteins are the primary receptors for chemotaxis and transport of many sugar based solutes.  The LacI family of proteins consist of  transcriptional regulators related to the lac repressor. In this case, generally the sugar binding domain binds a sugar which changes the DNA binding activity of the repressor domain (Pfam:PF00356).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.68	0.70	-5.20	6	5137	2012-10-02 13:57:41	2003-04-07 12:59:11	16	10	2047	27	638	25439	2217	255.60	21	79.54	CHANGED	shslGhllsps..csPa....ahclstulscAuppaGhslhLlssspps-tt...pthc.LtsptsDGllIs.ohssc..scIpthtct.shPVItsscshs.s......sVPssh.D.shpAut.psspaLlptGHcp...l...slhstssSsh.sstcRspGahsAltssGh....h+phplhpssschpsutpAlpphhpps..Pshp..AllshNDpsAhGuhhsh.tpGh.lcs.psVs..h.ulhuasuL........spsshl..s.lss.psstp.lGhpsu-hlhp.l........tp-pscslhIs.....thhhtcs	................................................................................................................................................s..tlGll.l.P....sl........pss.....a.............a.s...p.....l...h.p.u....l...p....p.....s........s....p.....p.....t.......G..........a.....p.....l.........h.......l.........h........p..............s............s.....t.....p......t....c.tt.............pt.l....c....p....l.......h.......s.......p.......t...l...D....G...l....l......l.......s......s........t.......s...............p................s...........p..........l......h.....p........h.......h.....p........t........s......h..P....l.......l...h...h..s....c..t.......t..s.s......................................s..l..s.....h....l.....h..........D......s.........h....p.........u.........u......h......p....h....s.....p........t.......L.......l.......p.........p......G.....p....c..+.............l......................u.h...l.....s.....u.......s........t........s...........t............h......s............s..........t.............c.........R......h......t............G............a.........p.......p.......A.......l.......p......p.....t.......uh..................h....p....................h..........h...........h........t.........s........s..............p............s..............h...............p.........t.............u..........h.......p........h.......h.......p....p..........h......h......p.............pt..................P...p.........hp..........ulh..s..h...s..-...p.h..A.h.G...s...h......h.....t.t...G..........h..p......h..s..........t..t.......l..............................s..h......u...h....p.....s.....h.........................t.....h.............s........l.....s............p..........................G...........s.s...p...hhh.t...l..........................................................t........................................................................................................................................................................	1	130	282	466
+3783	PF00141	peroxidase		Peroxidase	Bateman A, Sonnhammer ELL, Studholme DJ	anon	Prosite; PfamB-105, Release 14.0;	Family	\N	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.92	0.70	-4.87	162	7995	2009-01-15 18:05:59	2003-04-07 12:59:11	18	39	2016	398	2881	7388	3647	260.20	25	77.65	CHANGED	Vcphlpphhpp........psshus...sl.........lRLhFHD.........................................Chs...............t.GCDuSl.ll.......htsEcs.sss.Nt...uLc..uhc..................ll.....-slKspl-p..tC.st..h...VSCADll.................sLAucsulth...................s............GGP..hh.sl.hGRcDupsupt.tts...tl...........................................................P.................ss.t.shsp.lhptF.sphG.L.ssp-hVsL.u......................................GuHT..lGts+.Ct.h...........+h..................ths.thh...t.......C.......s....................h.h.D....os.................spFDNsYapsLhs....................................ptshhpoDtsLh....sss......pspshVppaAss	.................................................................................................................h....htthht...............tphus....hh..........lRhh.aHD................................................shs.........................................uGss..uuh.hh..............hss.pps.hss.Nt....sLc...uhc..................ll.....psl...K.pphsp.......t.................lShADl.l.........................sLAussulpt..........................................................s................Ghs...sh..shs.sG.RtDuhpspt..sth...t.l...................................................................P...................ss..hssspp...l...h.s.p...F...tp.hu.....h.s.s..p.Eh.V.AL..u................................................................Gu.H.o....lGt.sa.ss...........p............................t..th......t......................tspt..............hs.h..c.......sP...................................................................stasNs.aFtsLhs..........................................................................................................................ph..shh..poDhsLh..p..ss......th.c..tlschasp................................................................................................................................................	0	552	1714	2399
+3784	PF01328	Peroxidase_2		Peroxidase, family 2	Finn RD, Bateman A	anon	Sarah Teichmann	Family	The peroxidases in this family do not have similarity to other peroxidases.	21.00	21.00	21.10	23.70	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.05	0.70	-5.76	2	357	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	84	13	308	383	0	183.60	23	63.07	CHANGED	MFupll.hsuslssh.....tcs........psshhsassPGPsDsRuPCPAhNuLANHGalPHDG+uIoh.sl.sAh.sthsluss.hthAlssAhlls...stushhso.hNLs.LsE.ph.hEHDtShSRtDYhpussp.....DshsFstphFpp.Lshhsu.p.hshsshsth+htR.phppEhD..h.aotp+.l.sh.EouhhhuhluD...Psps....scl-Wh+haFppEphPY+.GW+.sSstppl..lsuh.utllhAs.....ssLPpG.ltssApsVsluFuu.hsPhhhshN........plhs	................................................sth................................................................a..ss..t..s......s...D........RuPCPuL.NsLANHG.........al.P..+s..Gt.s.l...o...ht...pl...h..p.....u........h..tp..s......hs.h....u..........s........................h......s....h...h.h...........h...h...............h.....h......................................................................................................t............h.........h.......s....L.......s....t........L..........s.t.......H.......sh..hEtDsSlsRtDhh........................................hht..............ht.............t....................s..............h...s.....h......p........t....................................................................................................................................................................................................................hhhhh.....................................................................................................................................................................	1	104	191	267
+3785	PF04088	Peroxin-13_N		Peroxin 13, N-terminal region	Wood V, Finn RD	anon	Pfam-B_8055 (release 7.3);	Family	Both termini of the Peroxin-13 are oriented to  the cytosol. Peroxin-13 is required for peroxisomal  association of peroxin-14 [1].	20.90	20.90	21.10	22.70	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.01	0.71	-4.27	29	243	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	221	0	175	247	0	154.00	37	39.23	CHANGED	GYG.........Gh.G..ts.s..shht..hspSTpATFQlIESllGAhGGFAQMLESTYMATHsSFFsMloVAEQFupLKssLGShLGIFAlh+al+plhtKlssthh...............tspuhssspF.ppFpspt....ps.ptt..........ts+.ShKPllhFluAlhGhPYLlsKllp	.........................hhsshYs.......uhh..s...s..s.ss.ss..phs.pp.hppSopusFQhIESIVsAFuuhApMLESTahAsaSSFh.........AhluVA-pFupL+spLuslhuhFsllRhl+plht+lpthhh..............hpssu.hs..stF..spapss.....t....s..t...........sss+sSphPlhhFlss.lhGhPYLhhKll.t......................................	0	50	87	141
+3786	PF04882	Peroxin-3		Peroxin-3	Mifsud W	anon	Pfam-B_6513 (release 7.6)	Family	Peroxin-3 is a peroxisomal protein. It is thought to be involve in membrane vesicle assembly prior to the translocation of matrix proteins [1].	26.70	26.70	28.40	27.20	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.32	0.70	-5.77	32	408	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	258	4	274	399	2	283.60	23	86.51	CHANGED	hsuhtsahpR+++KlhlsuullGusYl...lspashpK.lp-hpp+hsp-hhs+E..................pl+p+FcQsQp-CshTlLuL.LPslspslhc.tLssEplsppLppp+.........................................................................................p.............t....................................................................scsKhpLWs-LKIpolTRhlTllYolohLhlhhRlQLNlLGR+pYL-...........o...........................................................shthutsppttppsths................................................hpspppYLSh..SWWLLs+.GahplhshlcpsVpcsFssls.+ppLolschppllhplpptlpt........s........sspp..........hlshLlP...t....hl.po...................s.hss.s.....pssspLpcLlsETpcll..-SsshspVlpthlspuFsplh-plt.tphs.pt.s.s...........................tthsshsphp..............hpLAplLshlscQsptlssss.......................................sNpalpslpp.lccLcsFuAsVYos.F	........................................................................................................h.pppt.hhh.........shhssh...hh......h...h.h.t+......h.....p......p.....p.........tphh.pt..................ph..p.+..Ftp.pp.s.................s..h.h..h.h..ht..l.t.....hs.p.lh..lp............................................................................................................................................................................................................................................................................................................................................................................tp+hplWpplcl.shs+.hs.hashshL.lhh+lQlslluth.Yh.p..................................................................................................................................................................................................................t............................................................................pptaL.s.....ahhtp..Gh.th.p.hpt.l...t...ht.....hp.............p..p.....hsh.phtphh.tl...h..............................................h..hhhs......................................................................................h.thhtEh.thl..ps..h..lht...p..h.hhhpth..........................................................................................................h.hs.hh..ht........hhtt.........................................s.hl..t......h......ht.h...lht....................................................................................................................	0	85	138	210
+3787	PF03212	Pertactin		Pertactin	Mifsud W	anon	Pfam-B_2005 (release 6.5)	Family	\N	21.30	21.30	21.40	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.50	0.71	-4.39	8	2661	2012-10-02 14:50:22	2003-04-07 12:59:11	9	35	708	7	134	1809	3	114.80	27	13.74	CHANGED	VssLpLss.GsVsF.......usPAsssGpFpTL.slpoLSGoGsFhMNssls......supuDhLsVsssAoGpa+lhV+NoGsEPsSuss.LsLVcTs.GGsAuFTLuNtGGtVDlGTacYsLsss.....tNssWsLps	........................................................tl.hst.upl.h.......................p....s...t................a...sL..ss..s..p..L.s.G...s..G..s.hh.h..po..s..ls......ss..t..s..DpLsV...p.G...s...s.oG.s.hplt.V.ss...s...G...s.p.......s.s.......s.......s...s....t......lpllp.....ss.....s.....u.....s.....u........s......Fs......h......s......s.......................t....h....V...s......hGsYpYpLhps............s...tsW.Lh.s..................................	0	32	55	98
+3788	PF02917	Pertussis_S1		Pertussis toxin, subunit 1	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.90	20.90	21.30	21.30	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.55	0.70	-4.79	2	121	2012-10-01 23:25:29	2003-04-07 12:59:11	9	5	104	6	16	77	1	179.80	46	59.63	CHANGED	sPsthVYRhD.RsPE-lFppGFoshGsscNhh-Hlh....GRSh.luoSposhsuhp..tpah.Ehh.EH.hpthl.t.RAsp...HFhshhhpscs..shhtttpshF-.sDp.hsphGhhhhts.hsYQpEahsct.IsstNlR..othhhsulssEsspscassuR.VsppTRhN.Pp.ass+hp.hph.us...hhPs.Ghshshphp.spAhushs.ptGpuhsLs.ats.saS	...s..sDFVYRVDSpP.P.-lIFR...D.G....FohhG..h..NR...N..hQQaIS...........GR..SC...u...uGS..S...D.SpaIATT.So.....h......s.o.Ysh....t+uh.a.uR.ush.pG..plYRYQIRADNNFYShhsSl..s..YL-o.pGu..phs..th..p+sh...hph..Q...pEYlushsIhPENIpcAssl.laDu..sTG..s.p.s.s.p.h..NupYlshsTpSN..P...........................................................slh.hl...pthppphhshhh..hsth..ht.......................................................................	1	3	10	13
+3789	PF02918	Pertussis_S2S3		Pertussis toxin, subunit 2 and 3, C-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.90	21.90	23.50	27.60	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.42	0.72	-4.32	3	72	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	64	12	5	26	0	109.00	71	70.55	CHANGED	ThR+TGQPATD.HYYSNVTATRLLuSTNSRLCAVFVRDGQPVIGACsSPY-GR.YR-MYusLRRhLYhIYhuGLuVRVHVSKEEQYYDYEDATFpTYALTGISlCNPGuSl	.....TGDKT.....NAYYSD.EVISELHVGQIDTSPYFC.......IKTVKANGSGTP..VV.ACAVSKQSI.WAPSFKELLDQARYFYSTGQSVRIHVQKNIWTYPLFVNTFSANALVGLSSCSATQC.F......................................	0	3	3	4
+3790	PF02529	PetG		Cytochrome B6-F complex subunit 5	Bsahton M, Bateman A	anon	Pfam-B_1348 (release 5.4)	Family	This family consists of cytochrome B6-F complex subunit 5 (PetG). The cytochrome bf complex found in green plants, eukaryotic algae and cyanobacteria, connects photosystem I to photosystem II in the electron  transport chain, functioning as a plastoquinol:plastocyanin/cytochrome c6 oxidoreductase [1].  PetG or subunit 5 is associated with the bf complex and the absence of PetG affects either the assembly or stability of the  cytochrome bf complex in  Chlamydomonas reinhardtii [1].	20.80	20.80	20.80	20.80	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.63	0.72	-4.43	17	647	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	629	9	42	207	66	35.10	81	95.05	CHANGED	MlEPLLsGIVLGLlPlTlsGLFVsAYhQY+RGs.phsh	.....MIEshL.GIVLGLIPITLAGLFVTAYLQYRRGDQLDl.....	0	13	32	40
+3791	PF05115	PetL		Cytochrome B6-F complex subunit VI (PetL)	Moxon SJ	anon	Pfam-B_6510 (release 7.7)	Family	This family consists of several Cytochrome B6-F complex subunit VI (PetL) proteins found in several plant species. PetL is one of the small subunits which make up The cytochrome b(6)f complex. PetL is strictly required neither for the accumulation nor for the function of cytochrome b6f; in its absence, however, the complex becomes unstable in vivo in aging cells and labile in vitro.  It has been suggested that the N-terminus of the protein is likely to lie in the thylakoid lumen [1].	21.70	21.70	22.80	22.70	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.14	0.72	-4.04	28	723	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	681	2	17	306	0	30.30	69	83.62	CHANGED	MhTllSYhGhLhuuLshTlsLFlGLsK.IcLI	........M.TITSYFGFLLAALTITssL.FIGLsK.I+LI.......	0	8	12	14
+3792	PF03742	PetN		PetN 	Finn RD	anon	Pfam-B_3260 (release 7.0)	Family	PetN is a small hydrophobic protein, crucial for cytochrome b6-f complex assembly and/or stability. 	20.30	20.30	20.50	20.50	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.25	0.72	-4.38	22	1420	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	1364	8	44	221	4	25.50	91	97.19	CHANGED	MDIloluWuuLhshFTFSlALVVWGRNGh	.............MDIVuluWAALMVVFTFSLSLVVWGRSGL.	0	13	31	40
+3793	PF04614	Pex19		Pex19 protein family	Wood V, Bateman A	anon	Wood V	Family	\N	22.20	22.20	22.30	24.10	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.82	0.70	-4.76	27	341	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	273	5	218	335	3	236.60	24	75.49	CHANGED	ts-...........................sppshhpphppphppLhs.................................tttssptppphpphhpphst................ppsssstpsppss..............sFpsslpcThp+Lpcuucplssshtt.............s--hLsplLpshshss..........sss-tshtthl.sMMpQLsSKEVLYpPlKELpsKaPtWLcppps..plspE.chp+YccQhplsscIlppFEp..............tsYsDpp...cpct-tlhcLhpphQ-hGpPP..............sELluphsss........................tstsh.sshstt..-sCppp	.......................................................................ttt.t...........p.pt.h.tpLht..............................................t..thttphtphh.pthtt..................................................................t.th.tt....p.p..t.........t..t.......t............................pFppslpcThpt....lp.c.s..up...p.......hpssh.....................--...l....s.p..hhcths.s.t............................tssct....sh.shht....sh.MppLhSK-l..LYp.PhK....El......s-K.......aPpWLpppcs...........plstE.-hcRYpcQhplhpcIsptaEp........................ps.sDpp........tchchlh-...lMpp......hQphGpPP...............p-L.su-hsss..h............................s.......tC..................................................	0	68	120	177
+3794	PF04757	Pex2_Pex12		Pex2 / Pex12 amino terminal region	Bateman A, Wood V	anon	Bateman A	Family	This region is found at the N terminal of a number of known and predicted peroxins including Pex2, Pex10 and Pex12. This conserved region is usually associated with a C terminal ring finger (Pfam:PF00097) domain.	22.20	22.20	22.90	22.40	21.70	22.10	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.47	0.70	-4.94	113	868	2009-01-15 18:05:59	2003-04-07 12:59:11	9	26	288	0	602	841	8	218.00	17	58.58	CHANGED	-pplpshLpsplppllphht..............hhthhhp......atcEl.phlhphllhthshhp........tssohGEpahsLthhs..st.t......................................................................t.....phhsttp+hhhlhh..hlhhPYlhpKlpphhpptttpt..t..................................................................ptthhp.hhshlpsh..hphhphhphhhFlhsus......ahols.pRlhul+hshh............ttph.t...............................ssaphhsthlhhphhhphlhhhh......shh..h.hh.............s	..........................................................................ppl.shLtsplpphhphht.....................h.t..hhhp................atsEl.thhhphllhthslhp....................tssohG-phhsLphhs..t................................................................................................................................t..th.sttp+h.hhhhh.h..lhhPYl....hp+lpphhtpp...tt.tt....................................................................................................................................hphh.....hp..hhs.hlp.sh......hphht....hhphhhFlhsup............................aholh..cRlhGl+hshh..................ttphppt...............................................ssachhst..l...h.hph..h..h..phhh.hhh........hh..................t...............................................................	1	173	313	489
+3795	PF03011	PFEMP		PFEMP DBL domain	Griffiths-Jones SR, Bateman A	anon	Pfam-B_822 (release 6.4)	Domain	PfEMP1 (Plasmodium falciparum erythrocyte membrane protein) has been identified as the rosetting ligand of the malaria parasite P.  falciparum [1,2].  Rosetting is the adhesion of infected erythrocytes with uninfected erythrocytes in the vasculature of the infected organ, and is associated with severe malaria. PfEMP1 interacts with Complement Receptor One on uninfected erythrocytes to form rosettes [2]. The extreme variation within these proteins and the grouping of var genes implies that var gene recombination preferentially occurs within var gene groups. These groups reflect a functional diversification that has evolved to cope with the varying conditions of transmission and host immune response met by the parasite [3]. A recombination hotspot was uncovered between Duffy-binding-like (DBL) subdomains [4]. Solution of the crystal structure of the N-terminal and first DBL region of PfEMP1 from the VarO variant of the PfEMP1 protein is found to be directly implicated in rosetting as the heparin-binding site [5].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.34	0.71	-3.86	41	832	2012-10-03 17:31:28	2003-04-07 12:59:11	10	55	9	4	23	881	0	120.50	28	18.86	CHANGED	hFpcWVpphLcD..+h+.cKlspClpssct..p.spst..CpppCpChc+.WlppKccE.WppIKc+FpcQtchtp........................ttt.h.lpthLpph.h..shpcshsstcclp+lcchlpppttsstt...pst..s.......sppcshIDpLLp+.pccAcpCppppssps	.....................................alpph..p-h.+h+..cK..h.....c.spIN.ssp..ps..Ccss...........CpptCcsYcp.WIocK.K.p.EWDtlps+apshpsucp..................................................................................................................................................................................t................................................................	1	22	22	23
+3796	PF00365	PFK		Phosphofructokinase	Finn RD	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.75	0.70	-5.45	12	6795	2012-10-02 15:20:27	2003-04-07 12:59:11	15	15	3846	82	2001	4903	1585	268.50	35	74.02	CHANGED	K+IuVLTSGGDA.GMNAAlRAVVRpAIhpGh-VasIh-GYtGLlpG...pItplshtsVushlphGGThlGSARh.EF+pcEGRhtuhppLhcpGI-uLVVIGGDGShpGAphhppEau......................hsslGlsGoIDNDhsGTDhTIGhDoALpplh-AIDtIcsTApSHpRsFVlEVMGRaCG.lALhuGlAsGADhIhIPEts....h.p-plspplpcspp+GK+psIllVAEGshs....s..sphhcplhhpt.sh-TRlTVLGHlQRGGoPoAaDRlLAS+hGscAVchLLp	.....................................................................+IulLTSGGDuP.G.hNA.u.lR..u.l...V.......+...p....u..l....t............p........G...h...c...V..h..G...l..hc.G...at..G...L...l......ps....................ch....h...p......l......s......h............p......s...........V......s......s......h.....l.............p.......p..............G..G.T....h.L.G.o.u..........R..........h.............................t...........h...........p............p..............t............p.............s............p............t...........p............s...........h.........c.......p...........l.......c.c.............t........u......I-.uLllIGG...D.GS.h.pu......A...t...t.....L.....s...........chs................................................................................................l.s.slG..lPt..TIDN..Dl..s...u..T.....D........h........Tl.....Ga.....-T.....Alp....p....h....h.....-..u.l....D....c....l....+...s...T...u...s.............S....H....p....R...h.h.ll.E.................VMGRpsGalA...Lh.u..u....l.....A.......s.......G......u........-.......h.....l.llP.Ehs...........................hs.h.c....p...l...h...p...p.....l....p.......p.......t....h.......t.......c.......G.......+....p.......t...s........l....l.l.l.u.EGshs........................................................t...............p................h..................h..............t..................t.................l.................................t.................t....h...................................t..............h-.sRssl............L.......GH.hQRGGs..Pss..hDRhh..u......ophGh.Ahphl..t...................................................................................................	0	732	1287	1714
+3797	PF02901	PFL		Pyruvate formate lyase	Griffiths-Jones SR	anon	Structural domain	Family	\N	24.30	24.30	24.60	24.50	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	648	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.84	0.70	-6.10	129	4920	2012-10-01 23:28:04	2003-04-07 12:59:11	10	9	2399	26	529	2860	102	572.20	38	79.76	CHANGED	hh.....p............clsh....lppsh..h.ucss.l.s.........hc+shhlpctt+c.s......tGh.shs..scpspu........Ihspt.........shhI.......c-tElIVGhp.TstPhttshh....Pphuh+h.......lcst.hsh................................sapl.sppscchhpc.............htKotsctlhshastEh.......ptshcsslhT........uh.pshGtG+lhsDYc+lh.hhGlctlh.......p-tppchpphs.............................hht...hs....cchhchtcElu-p......pthpELtphAphhshs.ucP.ApshpEAlQhhaFs.aLushpEpNG.suhShGRhspaL.sYhc+Dlc.pGh...lT-cp.....AQELl-phhlKlp.lphhRssthsp.................hFuG.ss.ahshslGGhs....h-G.cshlschSahhLcsht..pl.tsspPslolhhs.pphP....csFhchssclshp..su..papND-lhh.................................hh.pD..DYu.lssCVps..h.............thG.....Kphpah...uAhhNl..uKsL.hslNsGhDph...ss......tplu.....P..ph.ssl..p..ph.hsa--lhpsacc.hcalschhlpuhNlIchhHcchs.cshh...uLh...Dsslp+shshsh....................sGlussuDSLuAIKh..........sKhhslc....c.pcu.................LsssFcsp.....................................................................................h....hPKYGNDD.....DclDplAtclsptahp.clcphps.h..R......suhhshulLolouNV.saG	...............................................................................................................p....clsh.....lppsh..a.scts.l.s..........h-+s.ht.hhc.tpp..p..........pu...shs.....sp.....hsps.....IhsptshaI....+c.....EhIVGhQ..sstP.hctshh.............P..h...u.lph.......lcpp..hs.....h.....................................................................shpl..s.chccl.ap-.............hp+Thpp...t.las..haos-h..........................................htspco..s.llo........uhss..sh..G...cG.+I...IsDYpR.lh..haGlchLh.......cctttphsplp................................................tthh....cchhcLtEElA...p...p..............hp...t....ht...p...........lhphAthhuhshppP.ApshpEAlQhhaFs.aLsshhppNG..uuhShGRhspaL..Yh.cRDlc...sGh....loEpp......ApEhl-phhhKlph.Vphl..R.ospasp..............................hF.u.G.ss.ahT.olGGhs............hD..G.......R....shVsc.SathLcolt..sh..uPpPNLTlhas.pp.LP..............tsFhchssclshp..pu..QacN.D-lhhs................................................pD..DY.ul.ssCVps...h...............hsG........Kphpaa......uAtsNl..AKslLhulN.GGhD-t........t.............h.p.h.u....................P...ph..tsl..p....s-h....Lsa-cVhpph-p.hhcalsphhl.puh.NlIchMH-+a.sa-shh...ALh...Dcsl.......tRshu.h.sh.......................s.G.lussuDSLuAIKh..............spsh.s.....lc.-.psu.................Ls.sDF-hp.........................................................................................tc...aP+YGN.s.D........-cVDsluscllcpahp.clcp..h.ps.h..R.......su.h.T.uhlTIouNVsaG............................................	0	178	334	439
+3798	PF01471	PG_binding_1		Putative peptidoglycan binding domain	Bateman A	anon	Pfam-B_2277 (release 4.0)	Domain	This domain is composed of three alpha helices [1].  This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation [2].  This domain may have a general peptidoglycan binding function.  This family is found N-terminal to the catalytic domain of matrixins [3]. The domain is found to bind peptidoglycan experimentally [4].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.50	0.72	-3.99	237	10090	2012-10-01 23:43:47	2003-04-07 12:59:11	13	329	3183	14	3243	8659	2140	56.00	25	14.51	CHANGED	psssVptlQphLp.ph.Gah...........t.........shs.....uhaustTppAlcpFQ.pthGLs.ss..GhssspThptL	..............................................................t...tlttlQ.phL..p....th..Ga.............................s...............ths............uh.a..ss....p..o.p..p.....A....l...+.pF.......Q..p.......t......t......G..........L.....s...s.....s.....Gh.h..stpThphh......................	1	982	1922	2518
+3799	PF00300	His_Phos_1	PGAM;	Histidine phosphatase superfamily (branch 1)	Finn RD, Griffiths-Jones SR, Rigden DJ	anon	Prosite	Domain	The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle.  Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue.  The superfamily may be divided into two main branches.  The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase.  The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases.  The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.35	0.71	-4.14	267	22415	2012-10-02 11:42:54	2003-04-07 12:59:11	17	114	4654	228	6555	16302	6276	153.40	22	62.77	CHANGED	plhllRHGp...........op...............................s........t....................hpGpt-.............LoppGtppApthu.pt......Lp................................................shphst.......lhsSshpRstpT....Aph.lsp..............................tht........................................................h.h....tL...pEhsh.s.............Gh.htphttth..................thtthhp......t...h..................................................shtphhp.Rstphlpplh............................ttspsl....llVuHusslpsl	........................................................................................lhllRHGc.........................op................................hN..................htt.h..............................................................hp.G.ts-..................s.s.....................Lo.p.p.G..t.pp.A..p..t.hu..p.h.......Lp..........................................................................................................................................................................s.h.p.hc.t..........lh..o...S..s......h.......p..........R.uhpT.........uph...ltp...........................................ths..........................................................................................................................hs.h...h.p.....pL...........pE.h.ph....G................h....................p....uh..p....h....t...p..h..t.t..th..................................thhp.................t.h.....s...................................................................................tuE.............s.h...t.p..hht...R.h.......h.h.pphh......................................................ttppl.....llsuHusslp...............................................................................................................................................................................................	0	2047	4021	5493
+3800	PF00342	PGI		Phosphoglucose isomerase	Bateman A, Finn RD	anon	Prosite	Domain	Phosphoglucose isomerase catalyses the interconversion of glucose-6-phosphate and fructose-6-phosphate.	20.50	20.50	20.50	20.50	19.40	20.40	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.73	0.70	-6.07	10	7325	2012-10-02 15:05:26	2003-04-07 12:59:11	14	16	5754	105	1399	5509	3130	366.00	35	89.39	CHANGED	DYSKsplss-hhptLlpLAcEttlcthp-tMFsGE+INsTEsRuVLHlALRsRospslhsDGpDVhP-VstVLs+MKsFs-+lRoGsWKGtTGKslscVVsIGIGGSsLGPlhVpEAL+shsps............plaFVSNVDGTalAEsLKpLssEsTLhlVASKTFTTsEThhNAcoAR-Wlhpthst.....cuuVAKHhlALSTNspcVcKFGIDsp..NhFsFWDWVGGRYSVWSAIG.LPlALulGa-NF-chLpGAcshDcHFsooPhEcNlPlLLALlulWhsNFhGspT+AlLPYDQhLa+husYlQQLsMESNGKhVopcG.shlsapTGsIsFGEsGTNGQHuFYQLIHQGT+lIPCDFIusVpopp......chssHHcpLhSNFFAQs-ALhhGKosEEV+pEh.tu........psLlPHKsFpGsRPosSILlscLoPasLGALlAhYEH+lhVQGhlWGINSFDQWGVELGKsLApsIhscLcsuthhs.....uaDuSTsuLI	....................................................................................................................................................................................................................................................ut...s......h...h....s.........l.p..................s...hth...tt....t.tl.hputhp...h..h.s..s.p.....ps..llsIGIGGS.L.....Gshhshc.........h......L.p......htt..........................................h.ah.ssN.lsss...t..........lt.c.hl...ph...l....................s............s.........c............s............s........h....h.ll..hSK.........ohTT.E..............shhs.hp.h.+phhh.p.t...h.t.......................ttt.....h.t+.+hhAh...o.s....p..t.....p...t.....s..h....c....h....t..h.stt........ph..F...h....D....VGG.Ra.SlhoAlG.Ls.....l.s.ls.h......ts..h..p.................phLp...G.A..p.t..h..-p...c.a......t...s..s...s..h.....c.....p.....N..................h.s..h.h.h.u...h..l.t..h...h.h...sh...Gh..tschl..l.s.Yp.t............hlphastahpQh..hESpG..K....sh.p.G.........................h..s....ush.a....oss.HuhhQhl.pp...........s..phh....h-h.lh...hpp.p............................h.p..p...h..s..h..sthph.Lh...GK....s....c..h.pt.ph.....t.........................l..h..s.a....p.s......h...G.h.Ps..lhh..p.l.sshslG..LlhhaEhthhh.pGhlh........sls..sF...........c....Q.G........VEhhK...h.tlh.......................................................................................................................................	0	472	905	1183
+3801	PF00162	PGK		Phosphoglycerate kinase	Sonnhammer ELL	anon	Prosite	Domain	\N	19.90	19.90	21.80	21.70	19.50	18.70	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.33	0.70	-5.91	154	5701	2009-01-15 18:05:59	2003-04-07 12:59:11	14	18	5059	60	1467	4176	4138	364.90	46	93.99	CHANGED	olcDl.........slpGK+VLlRlDhNVPl...c..s.G.......pIoD-sRIcuulP.TIchll-p.GA+.VllhSHLGRPc........................thps.........................chSLpPV...................................AptLuclL.Gpp...VpassD..s....lGspscptltth..psG-llLLENlRFpstEp.......................cscsphscpLAsLu...DlaVNDAFGoAHRAHASshGl..sphl...susAGhLhc+ElchL.sculpsP.pRPhlAllGGuKVSsKlpll....csLlp+..lDplllGGGMA.TFLtA.pG.hslGpSL...hEp..........-hlch...................A+cllpcA.cptthclhLPsDhllu.....cc.Fst...su.ps.psssssp..ls.....ss.hhsLDlGPcTlchasch.lppA+TllWNGPhGVFE.hssFupGTtslscAlAcs....su.hollGGGDosAAlpp.hGhs-.cho..HlSTGGGAsLEhLEGK	..........................................lpDl....Dl.p.GK+....VllRsDhNVPl......cs.G.......pIT..s.Ds...RIpAuLP.TIchhlc.p.G.u+.VllhSHLGRPct................................................................................................p.pt...................................................................chSLtPV...........................................................ApcLuch.L......u.....pp.......V.t...h.....s....s.........D......s..........lG.................p.lct.hht..t..l..psG..-l..lLLENlRFppt....Ep.................................Ks-.p.huKphAu..Lu.......D...l........aVN.DAFGTAHRAHASshGl..uphh.....sus.A..G.h.LhppElchL........sc.AlpsP...pRPh.lAIlGGuKVSsKlsVlcsLlcK.....sDplllGGGMAaTFltA..p.G...h.p...lG..p...SL...hEc......................Dhl..-h.....................................................A+c.llp.cA.pt..............plh.LP..lDsl...lA..................sc.......F........u....s.......sA.......p.....s....phs.....s...sss......ls......................ss....huLDI.G.Pc..ohc...h..asch.lp........s......A.KT........llWNGPh..GVFE.hssFup.GTpslucAlAcs.........suhoIl.G..GGDosAAlp.......p.......h.......G.......huD.chS.......aISTGGGA.L.EhlEGK....................................................	1	516	944	1234
+3802	PF00408	PGM_PMM_IV	PGM_PMM; 	Phosphoglucomutase/phosphomannomutase, C-terminal domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.44	0.72	-3.97	112	12833	2009-01-15 18:05:59	2003-04-07 12:59:11	15	36	4927	56	3279	9608	4242	81.50	20	16.51	CHANGED	.lNhplsc..t..........tt...htphtphhps........................htps.phhttcGhhl...............lRsSGTEPl...lRlhhEup.sppthpphtppltph...........lc	.........................................................................................................................................t...th.t......................................htsshc.h.h.h.s..c...G...t.......hl................................lRsSG....TEPh......lR..lh...sE..ut...sp.pt.hpphhpphh....h...............................	0	1056	2051	2778
+3803	PF02878	PGM_PMM_I		Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.69	89	14497	2009-01-15 18:05:59	2003-04-07 12:59:11	11	70	4976	61	3802	11145	5249	133.00	29	27.44	CHANGED	thhFGTsGlRGhss.tp......hssphshplupuhuphlppp.......ttsplllGtDsRhsutthtpshhpslsusGlcshhhG......hhPTPsluatscp..hp......ssuGlhlTASHNPsphNG....lKhhhss.Gttlsssh.pppIpphhpphptht	.......................................................t..hFGTsGlRGhhs..tt...............hs.thshplutu.h.up..h.ltpp.........................tptpl.llGt.Ds...R.......h......s......u.................htp.slhtsL.su..s..G..l.c...V.h..hhu..........................hhsTP.sl..u..a..hs..p..p.....hp..........................ss.uGlhlT.......ASHNPhp.NG.............hKhh........s.......s........s....G.....tt..lsssh...pptIpphhpt....h..................................................	0	1252	2394	3225
+3804	PF02879	PGM_PMM_II		Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.47	0.72	-3.70	98	14085	2009-01-15 18:05:59	2003-04-07 12:59:11	11	54	4971	55	3517	10795	4847	103.50	26	21.14	CHANGED	st....Yhcpltphht.......hptp...sh......p.llhsshpGsusthhtpllpp.huh..............phht.hptts-ssFss...phPsPpt....t.shp.hhphsppp.....ss.cl..uluhDsDuDRlsls.....cppG	................................................tYlphltshhs..............h..p..h..p........s.l..........................+..lllDshsG..s.utthssp...l...h.p.c.hGh...................................plhs..lpspP..Du..sFss.............ttssPpt...........t.sht..ht....p.h..s..h....cp..................tA...D....l....GlAhDGDuDRhhll.....cttG.............	0	1142	2220	2982
+3805	PF02880	PGM_PMM_III		Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.64	0.71	-4.03	584	13734	2009-09-11 23:52:46	2003-04-07 12:59:11	11	46	4950	49	3296	10440	4816	115.60	24	23.67	CHANGED	s.....GDp.lhslhuphh........hppt..........ht.s........s..lltTlhosh.ul-cshp...p.hGh..p.hh.cotVGc+alhct.hppt.....s.......h.shGGEpS.GHhhhh.ch.....tp.....s....sDGllsuLhllplhs.........pp..s..p....slu-lh.phhpt...a	.................................................................pGsp.lhslhu.phh.....hpp.............ht.s......................s.tllpolhooh..t.lc...c.hhp...p....h.....Gh..p.....h.h.c.......shsG..a.+a..lh......c......p......hpct.................................s............h..hhG.GEpS.ut..h..hht..ch...................................sp...........s......cDGlhs...slhl.h...p...hhs...........pp..s........p..sLs-lhtph.t...............................................................................	0	1070	2094	2795
+3806	PF04608	PgpA		Phosphatidylglycerophosphatase A	Mifsud W	anon	Pfam-B_5195 (release 7.5)	Family	This family represents a family of bacterial phosphatidylglycerophosphatases (EC:3.1.3.27), known as PgpA. It appears that bacteria possess several phosphatidylglycerophosphatases, and thus, PgpA is not essential in Escherichia coli [1].	21.00	21.00	21.50	21.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.95	0.71	-4.38	172	2384	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	2276	9	516	1528	1638	145.30	32	86.26	CHANGED	hphlut.shGsG.hh.hAP.GThGolsAlshhhhl...h..........hht.h..............hhh....hlhh.....shllGlahsstspc.ths.......hcD.utlVhDEllGhhlsh......hhh...............sh..............................h..............hh.ll......u.FlhFRhFDIhKPhPIshhD......cc................hp.............GG...hGlMlDDllAGlhAslshtlhh	.................................................h..hhuhhFssG.h...hs.P..GThGo.LAulshhhhh..............................ph.sh.....t..hhh.........hhlhhshhhGlhlsptst+..chs..........s+DcG.t.l.VhDEhlGhh.Ish......hhh...................s..........................................sh.............hh..shGFlhFRhhDhhKPhPIchhD...+p.................lc.............GG...hGlMlDDllAGlhAuhshhhh.t............	0	164	318	426
+3807	PF03334	PhaG_MnhG_YufB		Na+/H+ antiporter subunit	Mifsud W	anon	Pfam-B_3611 (release 6.5)	Family	This family includes PhaG from Rhizobium meliloti Swiss:Q9ZNG0, MnhG from Staphylococcus aureus Swiss:Q9ZNG0, YufB from Bacillus subtilis Swiss:O05227.	23.40	23.40	23.60	25.20	22.90	23.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.47	0.72	-3.93	234	1788	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1344	0	548	1242	226	82.50	33	67.13	CHANGED	hlllGuhhslluulGllR.hPD.....hasRlHAsoKusTLGsshlllushlhh........h........ptt......hsh+hlLlhlFlhlTuPlu...uahlu+AAhp	...........hlllGuhhslluulGllR.h.D......hasRhHAsoKusTLGshhlLlushlah...........spsh......................hsh+hlLhhlFlhlTuPlu...uHhlu+AAh.........	0	162	340	457
+3808	PF02304	Phage_B		Scaffold protein B	Mian N, Bateman A	anon	Pfam-B_9648 (release 5.2)	Family	This is a family of proteins from single-stranded DNA bacteriophages.  Scaffold proteins B and D are required for procapsid formation.  Sixty copies of the internal scaffold protein B are found in the procapsid.	25.00	25.00	150.70	150.60	19.00	16.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.58	0.71	-3.80	6	76	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	51	2	0	60	1	115.60	64	97.99	CHANGED	hpcNtssshopEsIpsospPQhRNEsshNsSs.pGssssT-PuGLRRDPVQpclEAERQcRspIEAGKuhCuRRFGGATCDDpSAcIaApFD.ssppVQPAEFYRFNDuElsKaGYF	.hTcNQssspSQEulQNpNpPQhRsEsAhNspuVpGshssT.puGLRRDuVQsDlEAERpKRs-IEAGKuhCoRRFGGATCDDKSApIYApFDcNDhRlQPAEFYRFpDuElNpaGYF	0	0	0	0
+3809	PF04717	Phage_base_V	phage_base_V; 	Phage-related baseplate assembly protein	Waterfield DI, Finn RD	anon	Pfam-B_5996 (release 7.5)	Family	Family of phage baseplate assembly proteins responsible for forming the small spike at the end of the tail [1]. Also found in bacteria, probably the result of horizontal transmission.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.39	0.72	-4.04	71	4590	2009-09-13 07:45:09	2003-04-07 12:59:11	7	55	1466	5	992	4204	146	90.00	34	15.09	CHANGED	Gslsslshs....p.............uR..lRVp..................sGs........h.osWl.hhsstAG..psppatsPslGEQVllh...sG..-.spulllsu.lassppssPsss	....................................................................................Gs.sAhVsu........p................hDp.GR..l+VpF.a........................t...tssc............p.Ss.WlRVup...sa......A......G...ts.......a......G.th......hlPRl.GpEVlVs....F.lsG...DP.D.pPllhGp.lYsspshsPh...................	0	209	482	739
+3810	PF03864	Phage_cap_E		Phage major capsid protein E	Finn RD	anon	DOMO:DM07502;	Family	Major capsid protein E is involved with the stabilisation of the condensed form of the DNA molecule in phage heads [1].	20.90	20.90	20.90	21.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-12.17	0.70	-5.51	77	1242	2009-09-10 22:20:44	2003-04-07 12:59:11	10	3	734	1	126	899	64	301.00	29	96.11	CHANGED	FssssLs.tsls...phs.hsshltsh..lFtp..p...s...opplsl-tp.sshhslh.shsshsssu.tht...ppptpspshpss..alt.ppslpss-ltshRsh.Gpp.............sthppht.phlsc..ch...tph.cpphchThEahphsAlts.p.lh......sscsss.hhDah.phshstts...hth....t.ts...ssh.spshpslcphpppl...phhsss..hslsusphastlhs..psplpc...thpth..t.........hp.............t..psh.patGhh..........................a.pcht................t...stph....hls.......sscshhhss.......t.shhpphausss...ppsss.u...............tshasp.h..pt.cspshplpspSsPLslsscPsslhp.sps	....................................................................................................as.tplh.th.p....ph....phpshhhpl..aFpps..........hs.hpTpplhlcpl....su.h..h.shu.shs.oPhs.tupslp....pcutps..p.hp.ss.....al.Ks+cpls.pp..h...hhRhs.sp-.................ssshphh.cllhpsh...ppt.cpulsts.Eh.sssAlh..tGK.hh........spth.p....hpl...Dh.....shstptph........t......phup..stss..h.cs.tpcl.ctht.th.......ush.sshhlhsspsap.hlps......acth+-......thcsppsu......................ttsl+.............shstsl..sa.pGhh.................lhhhpsp...Yhpp..................sG....spcp........als..................ssphllsss.........t.spGhphY.Gshp......tps.p.G...............sshYsKpa...hpss.cPstph..shspSsPL.lhs.cPsthl.lp..........................................................................................................................	1	43	83	102
+3811	PF05125	Phage_cap_P2		Phage major capsid protein, P2 family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	20.40	20.40	20.60	20.80	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.99	0.70	-5.55	5	788	2012-10-03 06:22:39	2003-04-07 12:59:11	7	2	540	0	77	634	13	308.10	45	94.81	CHANGED	RppFsAYLupLAKLNGlssscVu+..KFsVEPSVsQpLtNslQESSDFLKpINIlPVuEhKGEKIGlGVoGTIASTTDTuGsstR+spDhoALssN+YECsQINFDhalsYAhLDhWA+.FsDFQcRIR-AIlcRQALDhIMIGFNGTSRA-TSsRAsNPhLQDVAVGWLQKYRNpAPARVM....oE-sKooGKV...lls.GcsuDYcNLDALVFDusssLIDPhaQ-DPcLVsIVGR-LLADKYFPlVNKc.QcsTEplAuDlIlSQKRlGGLPAVcVPYFPAcAlhVTTL-NLSIYap--S+RRoL+ENP-KDRlENYESpN-DYVVEDYuuGCLlENIcV	.................................thssYhtplApLNuls.st..t..lsp......+FoV.EPoVpQpLcsthp-S.up.FLphI.Nl.hsVs-.pGphlslGssusIAuTs..-o.s.....s..pc.Rp.P.pc.st.l.tsp.cYcC-..QsNaDshlsY.spLDh.WAp.....a.pD...FQ.RlpstIs+p.ALDhIMIGFNGsp+A.c.sSsh.ssNPhLQDVNhGWLp+hRp.....-As.p.+VM..............sp.s....t....o....o....sph.............hts.....u......c..u.G....c..YsNLDAlVhDshssLI-.hap-Ds-LVVIsGRpLlu.schhPllN...pt....ppNoEhlAup.lIlSp+plGGL.AlpsPFFPssshLITpLcNLSIYaQcsocRRhh.h.-sPchcRlEsapShN-uYVVEDYttsuhl-pl..........................	0	9	29	54
+3812	PF05144	Phage_CRI		Phage replication protein CRI  	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The phage replication protein CRI, is also known as Gene II, is essential for DNA replication. 	21.00	21.00	22.70	22.20	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.67	0.70	-5.30	13	166	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	131	0	13	147	10	238.00	25	63.01	CHANGED	MIDalshclPhcc..............s.lshucVsplu....ssGsVEacs...spclpVsG.........SahouIul+sh...pus....s.tspLplcusPAKhhQGHNVaGo-DLpshshthapslhss.......hs-.hchlchGthplsRlDsTaShcLsocpplhuhLcuhcpsu+ppp+usts.shtoTlYFsKs..........SR+aoLphYSKt-Elp.thcs.............+ph.ctLspscLhpaAss+LRhEhpl+o+.Lpchs........lpasssapsc	..................................................................................................ls...splhphs....sst.tlpap.....tphpsps.........op.oshth+.h.........put........h.stlplcusPuKhh.QGH..NVaG.ss.....slphssth.hhstlhph..................sthhchl..s.s....tscloRIDhThshplus..c.hpphlcthpshuptpt...+sstp..s.htsTlaas.c.s..........u+ph.pl...phYsKt.sElp.pphpc......................p......tt.s.p...pp..h..h.....-.hp.t.spL.ta..u..ts..h..lRhEhph+pphLpchs..................h..................................................	0	2	6	12
+3813	PF02303	Phage_DNA_bind		Helix-destabilising protein	Mian N, Bateman A	anon	Pfam-B_9239 (release 5.2)	Domain	This family contains the bacteriophage helix-destabilising protein, or single-stranded DNA binding protein, required for DNA synthesis.	25.00	25.00	26.70	26.40	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.12	0.72	-3.96	3	81	2012-10-03 20:18:03	2003-04-07 12:59:11	12	1	61	22	8	90	1	84.70	33	88.25	CHANGED	lKVEI+sSQVuV+oRSGVS.+pGKPYTlp.EQpAYVDLGG-YPlLFsIsLDEGQPPYusGhYplHPuSFKlNpFGuLtlGR.lRLlPsK	.......................hpl..tt.th..psRshps.+pu..K..P.t.phh.EQpA....hl...hhG...Gp..aPs.hc...lpL-csQss....YssGhYplHssSa.hls.s.a...GsLplc+..h......h................	0	1	4	7
+3814	PF02305	Phage_F		Capsid protein (F protein)	Mian N, Bateman A, Haft D	anon	Pfam-B_10357 (release 5.2)	Domain	This is a family of proteins from single-stranded DNA bacteriophages. Protein F is the major capsid component, sixty copies of which are found in the virion.	25.00	25.00	70.30	26.40	19.30	21.90	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.78	0.70	-5.96	7	248	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	72	12	1	272	157	229.10	36	98.46	CHANGED	Spl.ou.hpRs.aDhSHhshpshphGcLhsI.hs.VlsGDoFphctsshhRLoshhhslhsc.plDhahFaVPpRhla.cpW.pFht-ssss..................uPhsuhspsohhDahGhsspls..sh+lsthhapuY..IaNsYFRs..h.ppstss.us.......hsts-sphs.............h+ss+h+shaTusLP.Pppthuhphsl...............................................................................................................uooulsI.uLptAhsh.+h.pccshhhoRYh-llpuahGspShDuc.pRP.hLhtosh.sss.sVstTspo........sLutFSsps..s.K+hhs+.FV.EHGhlhsLhhsRhs.TapptlchhhuR.phpa.Dhh..PsL.upLs.ptl..KEla..........tsusssthFthtEt.t.YRa+PspVssha.....psLDua.h...asshP......sLpcphl.ps.sshDcsht...Ssp.spa.sphhFNhpshRsMPshpsshh	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	1	1
+3815	PF03335	Phage_fiber		Phage tail fibre repeat	Bateman A	anon	Pfam-B_3576 (release 6.5)	Repeat	\N	20.00	5.00	20.00	5.00	19.80	4.90	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.45	0.76	-6.72	0.76	-3.45	38	2424	2009-01-15 18:05:59	2003-04-07 12:59:11	8	41	239	21	57	1692	4	13.50	43	14.97	CHANGED	susGsHsHohouss	....suhGuHoHoloss.....	0	14	30	41
+3816	PF03406	Phage_fiber_2		Phage tail fibre repeat	Bateman A	anon	Pfam-B_854 (release 6.6)	Repeat	This repeat is found in the tail fibres of phage. For example protein K Swiss:Q37842 [1]. The repeats are about 40 residues long.	20.20	20.20	21.10	20.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-7.95	0.72	-4.32	50	1985	2009-01-15 18:05:59	2003-04-07 12:59:11	8	103	486	0	146	1761	33	43.20	57	13.82	CHANGED	ohopKGllQLSSATsSsSEohAATPKAVKs.shDpAssphspsps	......ohspKGlVQLSSATNSsSE..o.LAATPKAVKA.AhDhAsu+hsspp.........................	0	4	69	102
+3817	PF02306	Phage_G		Major spike protein (G protein)	Mian N, Bateman A	anon	Pfam-B_8833 (release 5.2)	Domain	This is a family of proteins from single-stranded DNA bacteriophages. Five G proteins, each a tight beta barrel, from twelve surface spikes. 	25.00	25.00	27.70	27.70	24.00	20.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.10	0.71	-4.64	6	79	2009-09-10 23:22:16	2003-04-07 12:59:11	10	1	55	6	1	73	2	173.40	60	100.00	CHANGED	MFQpFlSKHNuPl.TSp.slusolTPAus.A..PVlsTPclou.+oslhlshTlTAuostuG.Fsasl+lDsosPssNQVlSVuAsLS.sVsuchIAslVRFEsAs.ssPTulP.uhYDsYPlE.uhtsGuuhSs+DCVTIDsHPRTsGNsVYVGlhlaSstWoAuploGllSlNQVs+EsTVLQPLK	.MFQsFIS+HNosF.hSc..lssSlTPAus.A...PVLpoPchou.pohah.ulTlsAus..uG.FhHslpMDTSsssuNQVlSVGAsluFsuDscahAClVRFESu..oVPTolP.osYDVYPl-.utpsGGhhoVKDCVTIDVhPRTsGNNVYVGhMlWSN.aTAo+spGlVSlNQVI+ElhsLQPLK	0	0	1	1
+3818	PF04688	Phage_holin		Phage lysis protein, holin	Kerrison ND	anon	DOMO:DM04726;	Family	This family constitutes holin proteins from the dsDNA Siphidoviridae group bacteriophages.  Most bacteriophages require an endolysin and a holin for host lysis.  During late gene expression, holins accumulate and oligomerise in the host cell membrane.  They then suddenly trigger to permeablise the membrane, which causes lysis by allowing endolysin to attach the peptidoglycan.  There are thought to be at least 35 different families of holin genes [1].	20.60	20.60	20.60	20.90	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.29	0.72	-4.44	24	332	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	263	0	29	157	1	44.80	42	47.79	CHANGED	GhsPlPlsEsplpphh.......SslhThssolhuWaKNN.lTp+u++ppphL.+	......GhSPIPlD--pl...........SollhslsuLashaKsNs.sopcGKhupphLK.......	0	12	20	26
+3819	PF04531	Phage_holin_1		Bacteriophage holin	Mifsud W	anon	Pfam-B_2644 (release 7.5)	Family	This family of holins is found in several staphylococcal and streptococcal bacteriophages. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis [1].	21.60	21.60	21.90	22.10	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.79	0.72	-3.92	23	523	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	423	0	29	274	7	78.90	39	81.28	CHANGED	pINWKlRhKNKshhsAlluulhLlspplst.....hhuh..shsph.pplpsllsslhslLshlGllsDPTTcGluDSppshs.YpcP+c	.............INWKlRh..KsKshhl.ull....uAlhLhhQ.plst........hhGh....chpshspQlss...hlNulLslLslhGVl......sDPT.T..cGlu.DSp.A.p.YptP+............................	0	11	23	27
+3820	PF04550	Phage_holin_2		Phage holin family 2 	Finn RD	anon	Pfam-B_61235 (release 7.0)	Family	Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the buildup of a holin oligomer which causes the lysis [1].	25.00	25.00	25.50	25.30	20.40	18.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.90	0.72	-3.89	6	181	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	164	0	22	73	0	89.80	62	93.82	CHANGED	Ms-uEKolIsLhlh....GALIulGKVLsGsEPIThRLhlGRhlLGoulShlAGlALlphPDls.lALsGIGSuLGIsGhpslElhLpR+...htup	...........MsscEKSlL.SLFhI....GsLIsVGKVLAGGEPITPRLFIGRMLLGGFVSMVAGVVLVQFPDLS.sAVsGIGShLGIAGYQVIEIAIQRRhKtp..........	0	0	8	13
+3821	PF05106	Phage_holin_3		Phage holin family (Lysis protein S)	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This family represents one of a large number of mutually dissimilar families of phage holins. Holins act against the host cell membrane to allow lytic enzymes of the phage to reach the bacterial cell wall.  This family includes the product of the S gene of phage lambda.	22.30	22.30	22.70	22.60	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.12	0.72	-4.02	25	643	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	434	0	62	284	2	96.80	31	90.20	CHANGED	Mscc.PchW..AslLshLpp.h...splhuuslAhlhAhLRhhY..sGssh+cpllEuslCGhlshshtssl.........pahGlssshushsGuhlGalGV-plRphspRhls+K	....................................t.h.pllshlhsth.....thhuslhAhshAhLR.hhY........sGsuhpcsll-uhhCGhluh..sltssL................c.ah....G......h.s..ps...luh..hhushIGalGs-plpshlhphhs++...............	0	6	17	39
+3822	PF05105	Phage_holin_4	Holin; 	Holin family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Phage holins and lytic enzymes are both necessary for bacterial  lysis and virus dissemination.This family also includes TcdE/UtxA  involved in toxin secretion in Clostridium difficile [1].	19.80	19.80	19.90	19.80	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.44	0.71	-4.42	57	986	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	662	0	122	758	27	117.20	29	83.22	CHANGED	lu...uhhshh..hGuhsthLhhLllhhll..DalT.GlhsA....hhp+c........lsSphGh+Glh+KlhhhllVhluthlDhhlhts......tslps.....s......llhaYluNEulSIlENhuphGlPlP...phl+phlc.pLpscs	.....................................................h..shhshh..hGshs.h.hltll.lhhhll..DalT.Ghht...A....hhptc............................lsSch..Gh.p.Glh.+Klhhh.l.lls.luh.h.lDhhlsss..................slpp....s.............l.lhFY.l.u.NE.hlSll.ENh.uc...h.G..l..P..l.P...phLpphlp..Lppc.p.........................	1	60	95	103
+3823	PF00589	Phage_integrase		Phage integrase family	Bateman A	anon	MRC-LMB Genome group	Family	Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase  (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.99	0.71	-4.59	35	44346	2012-10-02 14:09:14	2003-04-07 12:59:11	17	151	5378	81	8222	34800	8709	168.00	19	51.02	CHANGED	phLstcplppllstspp........thcs+sh......lplhhtTGhRhuElhsLchsc.lshppphhhl................psKsp+p...RtlPls...pthhphlcchltpp............tpc......................hlFssp...........tsp.hsppshppth+phstp.....sulp......thssHsLRHohuopLhcpGh.slcslQclLGHsslshT.thYs+sstpc	....................................................................................................................................................................................................................................tph....t.h..h..t......h.t........................p.....t..h.h............................h...l....h....h....h...o..G.h..R...h.......u..E.........l.....h..........s.................L......p...........h...........p...........-.....l...........s........h..........p........p.....t......h.....h...t..l...............................................................................tsK...s.p..pp.............+h.l...s.ls................pph....h.......p......h....l...p...p....h...h.ptt........................................t.p.p...........................................................................................................................h..l..F....st.................................................tt..p.......h.....s.....t....p.....s.....h.....p....p.....h....h........c..p....h...s..pp..............................ss.lp............................ph..s...s..Hs..h..R..H.o....h........u......o.......t...........h.........h.........p............p............G.........h........s............h.......p...........h........l.........p......p........h.............L.G.H......p......s......h...p....s....T....phYs+h....p..............................................................................................	0	2564	5275	6927
+3824	PF03245	Phage_lysis		Bacteriophage Rz lysis protein	Bateman A	anon	Pfam-B_3219 (release 6.5)	Domain	This protein is involved in host lysis. This family is not considered to be a peptidase according to the MEROPs database. This family Rz and the Rz1 protein (Pfam:PF06085) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway [1].	25.40	25.40	25.60	25.40	24.70	24.70	hmmbuild  --amino -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.49	0.71	-4.14	30	1696	2012-10-02 17:03:51	2003-04-07 12:59:11	8	3	601	0	80	1081	5	120.20	51	80.99	CHANGED	putphcpptschspplphsp....ssIschpsRpR........slAsLDs+aTcELu-A+uc.-sLRsDVAuG++RLp..lpA..oCsu...sspssusuulssuuusR..LsssApcDYhsLR-cItpsppQlpuLQ-YlRsp.Ch	.....................................NAlsYKtQRDcps.pc..L.c.hAN.....AsITD.MQh.RQR............DV.AALDA+Yo+ELADA+AEN-sLRs.DVAAGR...+RLp.......lpA.......sCss.......st.csTu.sSGhs.N.u.s.u.PR...LussA.....ERsYatLR-tlhphppQLcshQ-YIRoQC..........................	0	7	26	55
+3825	PF00959	Phage_lysozyme		Phage lysozyme	Bateman A, Griffiths-Jones SR	anon	Sarah Teichmann	Domain	This family includes lambda phage lysozyme and E. coli endolysin.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.47	0.72	-3.77	18	3255	2012-10-03 00:09:25	2003-04-07 12:59:11	14	30	1340	658	411	2608	736	110.60	29	59.84	CHANGED	hhTIGhG......pspslssp.t..................hopppusshhphslp.thtctlsphhp...........shstsphDAlsshsaNhGht...........hhttoohlcthpttphhttssplhc.h.s.G.......phhptlhpRRpp	....................................................hhTlshG...............sspslhsuhp........................................hocpps.stl.h.....t.h.-ht..ps...t.....h.l.p.p..h..lps..............hs.p.pt.s.u.ls.hsaNlGs.................Gth...t.sS.T........hh+.+...l.N...t.........G.....-..h..p..u..A..C....c..p....l.......h.t.W.h.h..s...sG.............pth..h...GhhpRRc.............................................	0	74	208	308
+3826	PF03863	Phage_mat-A		Phage maturation protein	Finn RD	anon	DOMO:DM08200;	Family	\N	25.00	25.00	25.70	25.70	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.33	0.70	-5.41	11	306	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	19	0	0	219	0	218.90	48	94.72	CHANGED	aaPcchht..hslplspYthsthhssp..hpthss..hhph...poPcphs..........sPssah.GhcslTslch.ssshhhph.sssscas.upusuuslchpsal..ss..........hhuphsashpsphsschtschSthssphGshluEuRcTlphLuhhhtplhcua+Al+RGDl+cltphlp.h...............................pptcapupssushWLEhpYGlhPLhhDIpushE.......-ah+sHtchthhhRhSsshGpshslphsth.Puhshh...slpspsslpRR.........pthahshssupLt.lS.....uluhlNPhpluWElsPaSFVVDWFlNVGchLEth..phhhslchlsG.hsp+clch+Sl.ol+shhssss.............shp.upspshtshhsRshpsshPpssstlcoshush.HllDulALl..sQRlK+	.......................E.sassolhsYscstp.sNuaShchhsN..........aTPtRhs......+pa+hPosaSpGhhsVTol-Q..GAapRphSshGRsa-.tsGhuhoLcsc.....us.phhs.s...hhh.hs.shssp.......................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+3828	PF04233	Phage_Mu_F		Phage Mu protein F like protein	Kerrison ND, Finn RD	anon	COG2369	Family	Members of this family are found in double-stranded DNA bacteriophages, and in some bacteria.  A member of this family is required for viral head  morphogenesis in bacteriophage SPP1 (Swiss:Q38577).  This family is  possibly a minor head protein. This family may be related to the family TT_ORF1 (Pfam:PF02956).	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.41	0.71	-3.55	13	1923	2009-09-11 06:39:01	2003-04-07 12:59:11	9	14	1455	0	257	1607	203	114.20	19	30.44	CHANGED	pplpssltpultpGpshcclu+pl+ch.................................th.s+tRhphlARspstps.sAuphtp..pptphtht.h..pasustDsRsRspHtcLcGpl.....aphD-..hp.sst.............PspchNCRCslh	.................................................................................................t..lpp.lhpul.h.p.G.p.....s...p..phtcplptt..................................................................hth.sp..c...h...pplhcTphsp.s...hs.tuphpp.......htph.sh.....t....h.....h....p.a.hu.....s....h...D.s...+...s....p...........p....t........p.....t..s.h.....c..G..p.h.........ac.....hc.-.sh.h.t...hth...........................................................P..s..p.......h.sCRCph.h..................................................	0	81	168	215
+3829	PF05136	Phage_portal_2		Phage portal protein, lambda family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.1);	Family	This protein forms a hole, or portal, that enables DNA passage  during packaging and ejection.  It also forms the junction between  the phage capsid and the tail proteins. 	26.30	26.30	26.60	26.30	26.00	26.20	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.98	0.70	-5.92	62	1366	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	672	0	152	1135	323	316.40	34	69.92	CHANGED	ustspphtsWpstst..ussstltt.shsplpsRuR-l.s+NsshusuulcphhsNllG.sGlp.p.tths.................spthpcplcphW.ppWs.ss...psDssGphsahthpplshRshl.psGEshsphhhtpts......shhhshplpll-sDpls...ssh...........ssss..p.......lptGlEhcphG+.lAYalhcs+Pssshht...........phpRlPAp.......pllHlac..pRsGQhR.Glshhusslh+lppLcpap-ucLhptcluAhhuuaIcpspss.ssshtt.ss........................t.ptpt.hplpPG.thttL.PG--lphhssscssssassFhpt.LRslAuGh.GlsYctlotDhssssYSShRtullEhp+thpthpp	.......................................hssphtta.s.sp..osDstlh..shpthpsRAcsL.scNsshussulphhp-+lVG..ph..hhlp..htss.hphh.............AcshscclcstW.pEau.s......h.DVpu....phTas.h.R.sltsah.hsGElFsphshspts......sthhthphchlpPchls.ss......................stus..............lptGV......pls..c..h..G.cshuYalhc..st..st.h.t............chpplstc.........phlHl.h.ps..h.cssQhR.Gs.s.hhuVh.plphLcphpsspLpuAhltAhh.ushIcpt.ss..ptshch.ts..............................................h..s.tt.l...pl.sG.htlscLhPG-clph.su.pcssssapsFcpu.LRhlAAGh..slSYpplu+sast.oYSutRtuhsEuhchahhhpc.............................................	0	47	88	121
+3830	PF05133	Phage_prot_Gp6		Phage portal protein, SPP1 Gp6-like	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	This protein forms a hole, or portal, that enables DNA passage during packaging and ejection.  It also forms the junction between the phage head (capsid) and the tail proteins. During SPP1 morphogenesis, Gp6 participates in the procapsid assembly reaction [1,2]. This family also includes the old Pfam family Phage_min_cap (PF05126).	24.50	24.50	24.70	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.23	0.70	-5.92	56	1289	2009-12-18 13:44:14	2003-04-07 12:59:11	9	4	997	13	170	1119	57	413.50	14	90.04	CHANGED	pscpltphlpcphtpppp......h..hppYYpu...p.chhppttt...............t.hthcp+hshsaschllcphsshhhspshphsts.....sp......pssctlpchhp...tNchcsptpplhpsshhaGtuahhhahs........pssp.....hchth..hssppshslassshppp.hshlphhpppspptht...............................plasssp..........hhhhphpss...thh.t.stttt..........................astlPlltasN.sc.p.....puch.cshhsllDshscsh..sphsschpshs.chlhsl........................hs...........................t.ttphhpshpptphhpl.................sssssschlp......pphsssshcshhctlcp.lhphutssshs.spthu.....ussSuhAlchthpthppcsppppppappulpchhphhhphhs.....tps.h...........clphsascsh.tshsppsc......sthtt...tGhlopc..shlpths.........hl......s..-scpEhc..chpp-ptphtptttsttp	............................................................................................................................................t..........................h..h.paaps...........p.phh.t..t................................h.s...p+hshsasphlscthssh.h.h..s..p..s.hphsts.............pp...........................ph..pt....lpphhp...........ts.p..h..ppt.p.phhppsh..h...hG.tu..a..h..h..h.hhs.....................ps..sp.......................hplph.........hss...p......p..h...h..sl.h.s.s.p......p.p.p.....h..h.h.lph...hp...p.p..t..t.pt.t...................................................pla.sss.t.............hh..h.h..hp.tt...............thh............st..t.......................................................hsh.lP..l....h...h.s..s.....c.p..............................huph.cphh.sllDthspsh.....uphss..p..h.p.th..t...phh.h.sh.............s........................................t.ttp..h.p.p.h.t...ptthhpl.......................................s.tss.ss.phlp.............tph...s...s.tth.c.shhc.tlp...p.lhphsttsshs..spphu.............ustSu.u.....hc..hp..h.shptpsppppphhp.p.ulpp.h...h...p.hhhp.hhp.......................t..............................plp...hpas...p...s..hshshtpth...p..........shht.......tGhlop.c...ph.ht..h................hh..............s..cs.p.tthc.....chppct...........t...........................................................................	0	61	125	149
+3831	PF05135	Phage_connect_1	Phage_QLRG;	Phage gp6-like head-tail connector protein	TIGRFAMs, Finn RD, Bateman A	anon	TIGRFAMs (release 2.1);	Domain	This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97 [1]. A structure of this protein shows similarity to gp15 a well characterised connector component of bacteriophage SPP1 [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.32	0.72	-3.84	81	1873	2009-09-11 08:37:08	2003-04-07 12:59:11	8	5	1271	14	232	1181	124	94.80	16	85.42	CHANGED	Ms.......................Lc......clKphLpl..-sspcD..sllpthlp....sApphlpsthsp.....................t.pphssthphhlhtlss.phap...p+ss..pupss........p.hsh..shpshlspl+th	..................................M...............LcclKthL+l....-psp...-D....chL.pt.hlp....sApphlp...s.hhst.......................................................................................th..sthph..s...hh.lss.hhYp.......ppt..........st.t............................h...........h............................................................................................................	0	72	146	194
+3832	PF04492	Phage_rep_O		Bacteriophage replication protein O      	Kerrison ND	anon	DOMO:DM04335;	Family	Replication protein O is necessary for the initiation of bacteriophage DNA replication.  Protein O interacts with the lambda replication origin, and also with replication protein P to form an oligomer [1]. It is speculated that the N-terminal half interacts with the replication origin while the C terminal half mediates protein-protein interaction (annotation of Swiss: P14815).	28.70	28.70	28.80	28.80	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.04	0.72	-3.80	9	670	2009-09-11 22:41:49	2003-04-07 12:59:11	8	3	446	0	27	476	7	97.40	48	35.34	CHANGED	phhEpR.....hADL-DGYhRlANpll-uhhtscLotRph..pVlhAlhR+TYGaN........K.hDhlsNsQlAplTs.......lssp+lscAhppLlccsll...ppsG.+hlGhNpslSpW	................s...E.p..VADL-DGYsRluNtLlEAhhhusLTp+Qh..pVhLAlhRKTYGaN...........K.hDhlossQLuElTt.......l..s+.+C.spAKppLV+hsIl.............hQpG....t.hGhNpslSEW....................	0	7	8	15
+3833	PF04984	Phage_sheath_1		Phage tail sheath protein	Bateman A	anon	COG3497	Family	This family includes a variety of phage tail sheath proteins.	26.20	26.20	26.20	26.40	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.39	0.70	-6.05	41	3025	2009-09-13 02:25:27	2003-04-07 12:59:11	9	6	1415	24	555	2645	2611	301.10	16	92.64	CHANGED	M...s.....tsphhPGhYlphpssuttshshuspGhluhss......shshGss.....spshpl.ssts...phhphhG..........hssphhthlcthhp.tsstplhlh+l.st....................Gspsssph...........................................................................................................t..hhtshhsGtpustltlhl..phstt...................................hshhh..ts..h............l.sp...........thh.....t.s.ht....................sstsltuGss..suthss.chht..........shssh...pshphshlshss.......tsp..slpssltshspphptt.ttcthullss.ss..s.......t...................-thhslssthshhsss.ht.............sssalAGhtAt.sshppuhss......hphsuhhslshp..hspsc....hpthlpsGhhshpts..ssslplhpslsohhp.s.tspspsatp.pslRshshlppsltpthpp.hhsctss......sc............sshtslpssltsah.cpLpstGslp.sacs......ptDhplpt.......................sscpsclhhphshpsVsshcplhhshplp	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.......................................................................h.......................thhh.hs...........................................h........h............................h.....hhs..h..hs......................................................................................................................t..h..........t..........h....................................................................s...hhhuhh.......uh...s....t.....s..................................t..........h.....s.......h...h..s...h..................ht........t.p................t..........h...............t.t....l..s....shh...........................t...t.h.h.h..t...shs..................s...h.....hhchhthl..p.tht...h...........hh............s......................hhttl..t.hh..tth.t.t..hl...shp...................t.....p...............................t.t.sth.h.h...t.....hc.h.h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	146	338	468
+3834	PF04630	Phage_tail		Phage major tail protein	Mifsud W	anon	Pfam-B_5341 (release 7.5)	Family	\N	20.70	20.70	20.80	21.20	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.01	0.71	-5.22	14	370	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	319	0	29	212	1	175.60	25	78.65	CHANGED	MA...ohGlctltluLlDspsshlh.cussGL.........ossGla.hDs....pshGTpTANITsLpuussplaGNNpltcsshupupPpVAhshNsLsa-lppKlhGhhsDscGGYs.ps..pKP.+VAlLlpS.pslDpsp.lYauFusGphsE.outNhsTss.supsRs-DslTasuLs.........pshsspshKha.ss-.................ssFs.pssMhp-VFsGYstsss	....................................................t...............................................pt....p..u.shphplosltsp.hscha.usN.t.lhh.t.t....pGsuclpschshhs.lP...s.-.shspllG.t.p.ccp..s.G.shh.hup...pspP.saVull.hEo..c.stsss.shaluLhKGpFoh..suhchpT..cp..cs..s..pss.plohphhs................t.tt....hh.h.h...t..t....................t...t...............s.......................................................	0	11	19	26
+3835	PF05100	Phage_tail_L		Phage minor tail protein L 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	25.00	25.00	25.40	25.20	20.00	23.20	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.43	0.70	-5.20	8	1425	2012-10-02 17:50:33	2003-04-07 12:59:11	7	6	613	0	63	1256	146	186.40	62	86.69	CHANGED	TshGu.-hhhFps...............E.pttGt........PlsWQGppYpsaPIpupGFEtsGcGousRPoLTVuNLhGhlouhspshssLVGApVlR+cTYA+FLDAsNFssG.NPsADPpQEh.lshWhlEQpot.su.posoFlLSoPs-hpGshlPuRphLusoCsWs....YR.G-sCGYsGsshhDcaspPToDsutDcCo+slouC+hR..ahtsNllsFGGFsuss+l	............................................T..GG.ERYFFCN................E.NE.K.GE................sVTWQGR.pYQsYPIpGoGFEhNGKG.ousRPoLTVSN....L.........a.........G........h......V.TG....M.AED......L......QSLVGuTVVRR+VYARFL.DAVNFV.sG.Ns..-....ADPE..QEl..hsRWhlEQhS-LoA..hoASFVLuT.PTETDG..AlFPGRIMLANTCh.....Ws..............YR..GDECGYs....GPA.VADEaDpPTo......Dl.p...K..................D+CS.KCh.p.GCchR...........s.s......l..sNFGGFLSINKL..................................	0	5	25	45
+3836	PF04761	Phage_Treg		Lactococcus bacteriophage putative transcription regulator	Mifsud W	anon	Pfam-B_3898 (release 7.5)	Family	This family represents a number of putative transcription repressor proteins found in several Lactococcus bacteriophages. Horizontal transfer may account for the presence of similar proteins in Lactococcus [1].	25.00	25.00	54.90	54.80	21.90	16.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.90	0.72	-4.20	2	33	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	27	0	3	26	0	56.50	75	97.85	CHANGED	M..EpslsHhGpsl.QcSVEaYKcpL.hc.ShpFlpsSLlPQLaEWSNAYKAAVELTK	....MpQEKTINHLGQlVYQESVEFYKEKLSVa.SKDFLQNSLIPQLYEWSNAYKAAVELTK..........	0	2	2	2
+3837	PF04985	Phage_tube		Phage tail tube protein FII	Bateman A	anon	COG3498	Family	The major structural components of the contractile tail of bacteriophage P2 are proteins FI and FII, which are believed to be the tail sheath and tube proteins, respectively.	22.40	22.40	22.60	22.50	20.80	22.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.73	0.71	-4.81	53	1069	2009-09-11 14:55:36	2003-04-07 12:59:11	9	6	755	0	146	654	22	163.70	38	97.85	CHANGED	slP+.pL+phNlFsDGpuahGplpplTLPKLstKhE-aRuGGM.sGslclD..hGh..-tL-sphshuGh.pt-llphaGhsshsustlpFpGuapppc.....upssslplshRGchpEl..DhGshKsG-csphphohssoYYKlsl.sGcsllEIDhlNhlptlsGsDhLus.hRpslGl	....................hlP+.+L+hhNlFh.D.G.p.shhGhlpslTLPKlocKh-pYRGGGM.sGuls..lD..hGL..sAL-spashuGh.pttlhpta....Gtssh.c.u..l...LRFsGuhpp-c.......u-s...s..lElhh...RGRhpEl..Dh.G-h..Kp.G..Es.s.ppphs.h.s.s.o.YaKLol..sG..csLhElDhlNh..l.h.l.sGsDhltp.hRsslGL.................................................................	0	28	72	114
+3838	PF05155	Phage_X		Phage X family   	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.1);	Family	This family is the product of Gene X.  The function of this protein is unknown.	20.80	20.80	21.00	20.90	20.10	18.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.82	0.72	-4.05	18	179	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	139	0	15	160	7	88.90	29	24.99	CHANGED	shsphuspphschspthphhhthWppG.scl+shl...s+uTFaRacpcLhphGlDhuph.sls+tsss.hlPLs+lL-scss......phP-WYhpPshhhs	..................hs.tGshshs+tsphhphYhhLhppG.psl.+t..th.........s+soaaRahpc.Lh.phG.lshuph.slschps...lPhschlphc.s......phPs..aYhcPs....s...........	0	2	8	14
+3839	PF02912	Phe_tRNA-synt_N	tRNA-synt_2_N; 	Aminoacyl tRNA synthetase class II, N-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.00	21.00	21.10	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.12	0.72	-4.25	53	4298	2012-10-01 23:07:44	2003-04-07 12:59:11	13	4	4261	7	933	2788	1981	72.50	33	21.23	CHANGED	tpApshcsL-plRVcaLGKKG.lTplh+sLGsL.ssEER.thGthlNps+pplppslsp+cptLcputlst+Lt	...................p.tAsshpsL..cplRVpaL.G.K.K.G.plT.thh+s..lt.sL.ssEERsthGthlNps+ptlppsls.....t+pptLcpttlpt+Lt................	0	317	621	796
+3840	PF02332	Phenol_Hydrox		Methane/Phenol/Toluene Hydroxylase	Mian N, Bateman A	anon	Pfam-B_15166 (release 5.2) & Pfam-B_3223 (Release 7.5)	Domain	Bacterial phenol hydroxylase is a multicomponent enzyme that catabolises phenol and some of its methylated derivatives. This Pfam family contains both the P1 and P3 polypeptides of phenol hydroxylase and the alpha and beta chain of methane hydroxylase protein A.	24.40	24.40	24.40	25.90	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.55	0.70	-5.06	23	1141	2012-10-01 21:25:29	2003-04-07 12:59:11	13	3	362	190	164	1148	22	186.10	33	63.63	CHANGED	sWs.papppcs.......ttpsl+hscWpsacDPhchhYtsYVphpscp-ststu.lhsuhscs+thpph.sstat.sphptth.sslphsEauA.hupuph.schu..husshpssusa.tshDcl...Rahphphhhhcchstps.phshup...+thaps-.uhpuhRchh--hhh.stDhhEshluhshsh-sshsshhahtL.sptAspsGDpshuhLhsuhpsDpsRHsphusshlphhlppstp	.......................................................................pttpppt..u.hh-uhspssu..th.cscah.pshKhhh.sslp.hEYtAhtu..u.hl.scph..sussh+suh.h..QslDEl...RHsQpphah.pta.t...pt.hshhp....pcha.sps.hhpss.+phF-Du.h.oussh.E.h.h.hu.lshshEhllTNlLhVsh.hphAAhNGDhsTsThhhSs.p.o.D.E.uRHhshGhps.lphhlppt..s...................	0	56	115	147
+3841	PF04663	Phenol_monoox		Phenol hydroxylase conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4509 (release 7.5)	Family	Under aerobic conditions, phenol is usually hydroxylated to catechol and degraded via the meta or ortho pathways. Two types of phenol hydroxylase are known: one is a multi-component enzyme the other is a single-component monooxygenase.  This region is found in both types of enzymes [1,2].	18.40	18.40	19.40	19.20	17.60	18.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.38	0.72	-4.23	25	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	72	6	28	84	3	66.00	43	56.72	CHANGED	s+DphENFpGtpLLYluW-cHLhFCAPhsLPlPPshPFGsLlppVLsssautHPDaA+IDWspspWh	.....+Dtp-NFsu..LLYlGW-cHLhFCuPhshPlPPshsFusllppVLsssautHPDFA+IDWuplpWh.......	0	4	17	26
+3842	PF04674	Phi_1		Phosphate-induced protein 1 conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4596 (release 7.5)	Family	Family of conserved plant proteins.  Conserved region identified in a phosphate-induced protein of unknown function [1].	25.00	25.00	35.00	32.20	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.02	0.70	-5.23	21	304	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	33	0	177	296	0	240.80	43	84.05	CHANGED	LpYHpGslL.sGsl.oVsllWYG+FsPsQ+ullsDFltSL.....Suss.............sssP..SVAsWW.+TscpYhptsssphs.......sslsLupQlhDpshShG+pLoctplppLAucu..u........tpsulslVLTusDVsV-sFChupCGhHutohsuhhth............phsYsWVGNStsQCPGpCAWPFHQPhYGPQus...........PLsuPNGDVGlDGMVhsLAohLAusVTNPauNGYYQ.GsssAPLEAAoACsGlYGsGuY.PGYsGpLLVDtsTGASYNAsGlsGRKaLlPAlaDPsoSsCsTls	......................................hpYHtG.s.lL...s..G..s....l.sVpllWYGpasssQ.......+..u...lltDFltSlosss.............s.tP...SVupWW.posp.tYh.ttsttt..................tplhlu..tph......Dp.th.Sh..GKsLpp.pl.plstpu..s...............tp.sulhlVLTutDV....s....V....p........s..........FChuhCGhHs.s..hs..u........................phsYsWVGNutpQCPGtCAW.PFt.tP.h..Y..G..Ppss.................sLhsPNGDVG..lDGMlhslAphLAsssTNP..as.suaa.p...G.......sssAP........lE............s...sssCsG.lY.GpGuh.s.GYsGplhsD.soGASYNs.Gh.pGR+aLlPtlasPtspsCts......................................	0	30	114	149
+3843	PF03831	PhnA		PhnA protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	23.00	23.00	24.00	24.40	22.00	18.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.70	0.72	-4.56	104	2536	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2436	2	438	1315	90	55.40	62	47.32	CHANGED	hh+DuNGshLp-GDoVolIKDLKVKGoShs.lKpGTtV+sIRL...st..sssccI-s...Kl-...G	.......hl+DANGNlLsDGDoVTlIKDLKVKGoS.ps.lKhGTKVKNIRL.....V....-GDHsIDCKIDG.......	0	121	255	351
+3844	PF02562	PhoH		PhoH-like protein	Mian N, Bateman A	anon	COGs	Family	PhoH is a cytoplasmic protein and predicted ATPase that is  induced by phosphate starvation.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.32	0.71	-5.09	164	6190	2012-10-05 12:31:08	2003-04-07 12:59:11	11	24	4026	2	1327	5544	4974	200.10	47	57.55	CHANGED	sI+s+ThsQppYlculp...ppD....lsFGlGPAGTGKTYLAVAhAVpuLpp..pcVcRIILoRPAV.EA...GE+LGFLPGDLp-KlDPYLRPLYDALa-hl........................sh-psp+hh..EcshIElAPLAaMRGRTLscAFlILDEAQNTTspQMKMFLTRlGhsS+hVlTGDlTQlDLP.ps.p.....pSGLhcAhclLcs.lc..uIuhsphsppDVVRHsLVp+.IlcAY-	..................................................................................................s.I+s+s.sQp.t.Y..l...p.slh.......pp-......llF..ul.GPAGTGK.T..........a.....L..A..l.....A..t.Al..p.A.L...pc......pp...l..c.....R...I..l....L.T..R..PAV....EA.............GEc..L.......G..F..L.P..G.D..l.p.....E..K..l..-.....P..Y...L......R.P...l..Y....D.....u..Lhph..l....................................................................u.h..-..p...h....p..c....l....h...-...+.....s.hI.E.l.......A..PL......A......Y...M......R...G.....R..T......L......s...c......AF..lIL.DEA.QNsThpQ......MKMF....LT.R.l....G..h.s..S...KhVl.......oGDl.o..Ql.DLP..ts..h...............pSGLtp..AhchLc..s...lc..........tlua.sph...p..t.pDVVRHslVtcllpAY........................................................................................................................................................................................................	0	436	867	1125
+3845	PF02114	Phosducin		Phosducin	Mian N, Bateman A	anon	IPR001200	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.53	0.70	-5.67	2	1240	2012-10-03 14:45:55	2003-04-07 12:59:11	11	6	686	7	485	1332	19	169.10	36	84.47	CHANGED	ht.ApSpo...hE.shEG.uspTGPKGVINDWR+FK.LEoEpp-p.s+phccll+phS...........pppcpKD.pE+hStKMolpEhthhcKsh-DEphLppYR+QpMp-M+QpLphGPpat.VhEl.SGEtFL-hI-KEQK.ThIhVHIYEDGl.Gs-AhNushICLAAEYPhVKFC+l+uSshGAusRFopssLPsLLlYKuGELluNFlpVT-QLuE-FFssDlEuFLpEaGLLPEKEhhVLppsp........-pDhE	..........................................................................................................................................................................................................................................................................................................l....p..t..-..c.E..D.E...p..h...L..c...p.....YR........c.+pMp....-h........+.......p.....c......L.......s..........h.......s........s.....+..........a.....G......p.....l......t.........E...l.......p...........s............G-................pFL..........-...s.....l....................E.......................+.......p.......p........K..s...s.................s....l.......l...VHl..Y.-..-..u......l...p.....s..Cc..l......LNssL..s....s..L.As.cY.s.h...V+..FCK.I+.A...s.s...s...s.....s.t...........-+....Fss...cs..LPTLLVY+.s.G...-LlusFl...uls.-..ph..............................................................................................t............................................................	1	154	244	369
+3846	PF00068	Phospholip_A2_1	phoslip; 	Phospholipase A2	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognised. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognises both families.	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.18	0.71	-3.86	37	1645	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	315	390	515	1676	0	114.20	33	69.11	CHANGED	NLhQFtpMIppss..Gppshh.pYssYGCYCGhGGpGoPhDshDRCChsHDsCYucs.p.sGC.....pP+hstYoYpppsGs.lsCss.pssCpptlC-CD+sAAhCFups..sYN.pphh.....shsp..sc+C	................................lhphtpMIpphs....sp...pshh....p.....Y...tsYGC....YC.............G..........h...........G........G........p...........G.......p.....P..........hDs.....h..D.+CChs..HD..sC...........Ys........c..s....t...........t......ps.C..............pP...p....h.s.t..Y....s....a......p...h..........p........s...............s.......p.......lh......C........s..........s......p..........s........................Cpp.lCpCD+t.uAh.C..h.tps......sYs.pp.hh................................................	0	195	222	307
+3847	PF04185	Phosphoesterase		Phosphoesterase family	Bateman A	anon	Pfam-B_1803 (release 7.3)	Family	This family includes both bacterial phospholipase C enzymes EC:3.1.4.3, but also eukaryotic acid phosphatases EC:3.1.3.2.	20.40	20.40	20.40	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.43	0.70	-5.26	20	2105	2012-10-03 20:55:17	2003-04-07 12:59:11	9	30	757	2	743	1807	98	335.40	23	58.08	CHANGED	lcHlVllhpENRSFDHhaGphsssps............................st.h....h.....s..stt...sh.p.sa...s.t.s.shhsu.h.ps..Hth.t.t.thstGh.tD.h...........shs.shsMuhaptpclPha.atLAcsFslsDpaFsSl.GuTpPNRlalho.uss.....................cssGs................................................puss.ls.st..........tsashpshs-pLppsGloWslYppthsssh..............h.sh...................................cthhtssthtphthssFtpDlcpspLPpVSalhs.......sssps-...HPuass..tGspalspllcsLtusPp.WscTlllloYDEsGGaaDHVssPsssh.s..sthh.............s..s...........ht.hGLGsRVPshlISPa..s+sGhlscp.........paDHoSlLphlcppFs....ls	............................................................................................................................................................................................................lcplVlhh.EN+SFD.......phhG...h.....ssps............................................................................................................................................................a...............................................t...........h....t....................h.....t.....t..t....h..t.t...uh....s..............................................t...shsha............p..t..p..p..hPhh..hsL....AptaslsDsaa...........s....uh.....hs......sotP.N+.hhhho.uss..........................ss..t..........................................................................................................ss.ss.h...t....................sh..s.hp.s..h.s-...tL...pp..s.....G.....l.o.W...t..hY.t.pt.....h...........s....s....h......t.............t..................................h..........h........................h............t........................................................................................................................tt.t.h.s..t.th.....t.....h.....h.s.pFht.clt......s......s..p..L.P.p.V..oa..lhs......................sts...st...............H..............P..........s.............s..........s............................st........G........s.........h........altp.......ll.pslp...psPp...W..p....c....T....slllsaDE....s.s..G...a......aDH..V.s.s.s..h....ss.........................................................................................ht..G..R.lPh.hll.SP..a....s+s....Gh.Vspp.....................ha-HsSlL+hlcphaul....................................................................	0	244	433	617
+3848	PF04272	Phospholamban		Phospholamban	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Domain	The regulation of calcium levels across the membrane of the sarcoplasmic reticulum involves the interplay of many membrane proteins. Phospholamban is a 52 residue integral membrane protein that is involved in reversibly inhibiting the Ca(2+) pump and regulating the flow of Ca ions across the sarcoplasmic reticulum membrane during muscle contraction and relaxation [1]. Phospholamban is thought to form a pentamer in the membrane [1].	22.40	22.40	22.40	95.30	21.10	22.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.79	0.72	-4.52	2	32	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	28	15	20	25	0	52.00	90	96.41	CHANGED	MEKVQYlTRSAlRRASTlEhs.QARQpLQpLFlNFCLILICLLLICIIVMLL	MEKVQYLTRSAIRRASTIEMPQQARQNLQNLFINFCLILICLLLICIIVMLL.	0	1	1	4
+3849	PF00922	Phosphoprotein		Vesiculovirus phosphoprotein	Bateman A	anon	Pfam-B_1160 (release 3.0)	Family	\N	20.50	20.50	21.70	21.50	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.80	0.70	-5.19	5	426	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	22	22	0	209	0	151.00	51	89.39	CHANGED	oR...LpphLKsYPcL-sTLu-I-EhE-ppc-cssp..FpsDusscsopPSYYLu--hc-S-oEsssEDspsl.splPPsspVE.a.ts.spDshhDDDl.....sVsFs-c.sWosslpKsssG+tsLcLouPpGLTstQhsQWpcoIcAls-pSKthRLupspIcsou-GLllpER.MTPslSsoo...................-.hPsSssSssoopslS.......o.posoPuspSssS...LGLP-lsus....uhh.+EhpLsPlsuSssPYcsTLs-LFGSp-ualsYsssGshSLK-AlIuGLK+KGIYN+IRI	.......................................................................................................................................................................................................P.GLot.QpsQWhhTIcAVspSuKaWNLuECph.sSs-slIlKtR.hTPDs.pss.......................h.psps.pSEulS.........................slWsLppT.........shphpsK+AulpPLTloLc-LFuSctEah.hssptt.p.hthhlhGl+h++LaNp..............	0	0	0	0
+3850	PF00343	Phosphorylase	phosphorylase; 	Carbohydrate phosphorylase	Finn RD	anon	Prosite	Family	The members of this family catalyse the formation of  glucose 1-phosphate from one of the following polyglucoses;   glycogen, starch, glucan or maltodextrin.	19.00	19.00	19.10	19.00	18.60	18.90	hmmbuild  -o /dev/null HMM SEED	713	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-13.21	0.70	-6.65	9	4954	2012-10-03 16:42:30	2003-04-07 12:59:11	15	27	3182	252	1289	3940	903	590.10	40	79.46	CHANGED	ALhpLGlsLEELhEpEpDAGLGNGGLGRLAACFLDShATLsLPuaGYGlRYcYGhFcQpIscGtQsEhPDtWLchGsPWEhpR.-hphsVcFaG+Vp....psupt..hcW.psphlhAlAYDhPlPGYcssssNolRLWSA+s.sp-FNLscFNsGsYlsAlpp+ppuENlocVLYPsDsphpGKELRLKQpYFlVuAoLQDIlpRaKpsc........psasshscKVAIQLNDTHPsLuIPELMRlLlD-EphsW--AW-lTs+TFuYTNHTlLPEALE+WPVcllcpLLPRHhpIIaEINcRFLptVtppaP.sDhc+hcphSll-E......t..+pV+MAaLslVGSHsVNGVAplHS-llKpclFsDFhplaPsKFpNKTNGITPRRWlthsNPuLutllsctlG.-cWhssL-.LpcLcpasDsstFhcphtplKptNKh+LAcaltpchsVplNPpuLFDVQVKRIHEYKRQLLNlLHVIshYpcIKcsst...tphsPRssIhGGKAAPuYahAKpIIKLIssVA-VlNsDPtVsshLKVVFlsNYsVSlAEhlIPAuDlSEQISTAGTEASGTuNMKFsLNGALTIGTLDGANVEItEclGc-NhFIFGhps--VpplcccG.YcspcaaptDscLcpVlppIpsGhFuP.psctFcsllsS......l.asDhYhVhtDFtuYl-sQcpVDphY+spcpWsctuIhNhAssGhFSSDRTI+EYAccIWslcP	....................................................................................................................................................................................................................................................................htthsh.s.lpcl.-.........E.DsuLGNGGLGRLA...A..C..FlDS.hAolshsuhGhGlpYcaGhFcQth....s..G.QhE...P...-.W.....h.p........t...sW...h.c.....p...........hth...V..ta.h.G..h........................h......lhu.saDhs.......lsG...Yps.t...s.spsLRLWpups....t...h...s.h..t..Fs.t.G...t....a.tu.tpt..scslotlLYPsD.sp....tG+.L.RLhQpYFhsusslps.Ilcca.h..t..t...........t.sh.p..ph.s-..h......slp.lND..THPs.lu.IPELh.Rl.L.....l.D..pct.hs.W..-c..Aapls..pps.......huYTNHTlhsEALEpWslphhpp.lL.PRhh.p..II.cI.s.pp........ah.t................l.p.t.....p..h....s.....s..s...........t....h...h..tp..h.ull.c.-.................................s.....t.p......V+MAhLsl.hsu.a.pVNGVutLH...oc...l............l......pp...sh.h......t.c..a...h...p....l.....a.....P.....p......+......F..p......N......h......TNGl.........T...........R.....R..................W..................l......................h...............s...NP.........tL......u..t....l.l....s.................c................t.......l...........G.............c........p........W......h.........p.....-...................h.................s..............p..............L...p.....p........L...........p....p.........a.........s.............-.....c..........s...........t....h......t.........p.......p............h........t...p........l.......K....................h.........p............N............K..h...........+......L.........A.....p..........a.....l.........p.........p..............p..............h.................s...............l..........p.................l............s....P.....p............u.............l.....F.........D......l............Q............l......KRlHEY.KR.QhLNh..L..al.....lt..hYp.c...I+.p.s..sp.............hphhPR.s.h.lFuG..K..AAPuYhhAKpII+.hI.splAchlNsDP.tlsshLK.V.......VFl.NYsVShAch..lI..............PAuDlSEQIShAupEASGTuNMKhhLNGALTlGTlDG...................ANV..................E..hh-....tl.G.....t-N.h.al.F.G..p..s-p.V...t.h....h...t.p..s.................Y....p...s....h....phh.p....ts...tlctslp..l...s.G..h.h...s.s........p........t..h....aptl.h.pp........h......t.....D.ahlhtDatsYhcs.p...................cpltt..Y..........p.s.t..........p.tWhphs.lh.....NhAp.G.hFSSDRoItpYspcIWph........................................................................................................................	0	432	793	1068
+3851	PF00124	Photo_RC	photoRC; 	Photosynthetic reaction centre protein	Sonnhammer ELL	anon	Prosite	Family	\N	21.90	21.90	22.10	21.90	20.10	21.20	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.54	0.70	-5.36	55	8728	2009-09-11 05:37:13	2003-04-07 12:59:11	14	5	3408	262	234	6932	2419	232.40	49	91.25	CHANGED	lYlGahGlhol..hhuhluhhlIuhshhsss........sassh..hpphahlulpPPsspYGLu.hsPLtE.............GGhW.hsshahssulluWhlRpachu+pLGhGhHlshAFuuAIhhalsLslIRPlhMGSWucuhPaGIhsHLDWssshuhpYsNhaYNPFHMLuIuFlaGouLhhAhHGuhILussphs.sscplc..hs.t.usE+ts........hFaR.hh....GashstcuIHRauhahAlhsshhuulGIllo..................Gsll.....csWhpWhshashsPha	............................................................................................ss...htphh.hul.ssusuhGhp.hhPlWEsts.s...cWh..GG.apllshHhhlGlhsahsRpaELuh+LGMRPaIslAaSAPl..AAhsuVFL.lYPlGQG.SaS-uhPhGIuupFsFhlsFQucH.NlhhpPFHMLGVAGVFGGuLh.uAMHGSLVpSoL.....h......h.E......s.s-.......st........otshuachuQEEETYsh......VsApsaFucLIh......suFN..NoRuLHFFhhhaPVsGlWho.....ul.Glssh..................u..h.....tsa.ph..h.......s..................................................	0	46	140	195
+3852	PF01895	PhoU	DUF65; 	PhoU domain	Enright A, Ouzounis C, Bateman A, Cerutti L, Dlakic M	anon	Enright A	Domain	This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [1]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.15	0.72	-3.54	388	11541	2012-10-02 11:27:25	2003-04-07 12:59:11	14	27	3795	24	2708	7226	2003	87.20	22	51.69	CHANGED	ltchuphst.phlppuhpu.h...hpp.D.....phA.ppl.h..pt....-cplDph........tppl..........p.....phhphh.tt..pp..sh.....................hp....h..h.....hht..lspslERluD.aussIAchs	..................................................pMuphst.ph....lp.pul.pu..h.........hpp...D....h........chA..pcl..h...pp..........Dcp.lsph.......pppl.............pc....phhphh..sp.......ppshtp...................lph...h...hs...hlp...hspslERlGD.autsIuch.h.....................	0	935	1793	2290
+3853	PF00502	Phycobilisome		Phycobilisome protein	Finn RD	anon	Pfam-B_10 (release 1.0)	Domain	\N	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.93	0.71	-4.47	22	4056	2012-10-01 21:46:00	2003-04-07 12:59:11	14	6	1323	188	272	2702	388	96.30	32	84.97	CHANGED	TpllssADspG+ahosu-LpulpuhlppustRLcusptlssNtssIlppAuptlascpPplhssGGssYssRph..AtClRDhcaYLRhlTYulluGssusL--hslsGl+EsYpuLGlPsushsculphhKss..shphlu......................upsssEhssYFDYslsulu	...............................................................................................................................................................hh...............................h....thths.......................................................................t.....................................................	0	37	167	246
+3854	PF02333	Phytase		Phytase	Mian N, Bateman A	anon	Pfam-B_14843 (release 5.2)	Domain	Phytase is a secreted enzyme which hydrolyses phytate to release inorganic phosphate. This family appears to represent a novel enzyme that shows phytase activity [1] and has been shown to have a six- bladed propeller folding architecture [2].	18.90	18.90	19.30	18.90	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.35	0.70	-5.75	2	586	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	259	7	131	592	319	193.30	42	71.03	CHANGED	MphsKThLLosAAGLhLohsAsSspA.Hhls-.aHFpVsAtsET-PVsousDAADDPAIWlc.KpPppSKLITTNKKSGLsVYsL-GK.LHSYchGKLNNVDlRYDFPLNGcKlDIAAASNRSEGKNTIElYAIDGcpGpLpSITDPN+PIuosIsEVYGFSLYHSQKTGtaYAhVTGKpGEFEQYElssstpGYloGKKVRtFKhNSQTEGhsADDEYGsLYIAEEDEAIWKFsAEPsGGSpGpVlDRAsGcHLTsDIEGLTIYYAssGKGYLhASSQGNsSYAhYERQGpN+YVAsFpITDG.chDGTSDTDGIDVLGFGLGPcYPaGlFVAQDGENIDpGQtsNQNFKhVsWEpIAp+lG.hPplpKQVsPRKhpDRS	.....................................................................................................................................s.DA.....A...DDPA....lWlpPp......sP......s...p...Sh...lluTsK....c....u......G..Lh..VY..DLsG+...l..Q.....................h..........s...s..........G...+.h...N....NV..DlR....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..................................................................................	1	46	81	114
+3855	PF04833	COBRA	phytochel_synth; Phytochel_synth;	COBRA-like protein	Waterfield DI, Finn RD, Bateman A	anon	Pfam-B_4078 (release 7.6)	Family	Family of plant proteins are designated COBRA-like (COBL) proteins.  The 12 Arabidopsis members of the family are all GPI-liked [1]. Some members of this family are annotated as phytochelatin synthase, but these annotations are incorrect [3].	19.00	19.00	19.10	21.20	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.41	0.71	-4.49	22	265	2009-09-11 09:29:15	2003-04-07 12:59:11	10	3	41	0	152	243	23	163.40	49	35.02	CHANGED	YlAhVTlpNap.ht+lps..WpLuWpWt+cEhIaoMpGApso..-puDC.....upah..hshs+...sCc+cPslVDL.PupshspQluN...CC+sGsl.shu.DPupStSuFQhpVuph.....sssppslpsPpNFplpu.....sPsYsCGsshhVsPT......pF.sssG.ppsTpAl........hTWpVsCshoQ	..................YlAhVTh.NaQ.aR.+Ip.s.PGWpLGWsWAK+E.lIWSMhGAQsT..EQGDC...........S+FK........ushPH....sC++sPs.lVDLLPGsPaNpQ...l.uN...CCKuGVlssa...sQDP.u......susSuFQloVGhu......G.T..oN.c.TV+hPpNFTLtu....PGPGYTCGssthVs.sT......pFhosDt..+RpTQAl......................hTWs.VTCTYSQ..........................	0	22	94	125
+3856	PF00360	PHY	phytochrome; Phytochrome;	Phytochrome region	Finn RD, Mistry J, Hughes J	anon	Prosite	Family	Phytochromes are red/far-red photochromic biliprotein photoreceptors which regulate plant development. They are widely represented in both photosynthetic and non-photosynthetic bacteria and are known in a variety of fungi. Although sequence similarities are low, this domain is structurally related to Pfam:PF01590 [1], which is generally located immediately N-terminal to this domain.  Compared with Pfam:PF01590, this domain carries an additional tongue-like hairpin loop between the fifth beta-sheet and the sixth alpha-helix which functions to seal the chromophore pocket and stabilise the photoactivated far-red-absorbing state (Pfr) [1]. The tongue carries a conserved PRxSF motif, from which an arginine finger points into the chromophore pocket close to ring D forming a salt bridge with a conserved aspartate residue [1].	20.30	18.00	21.00	19.50	19.90	17.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.12	0.71	-5.15	80	3555	2012-10-02 14:34:25	2003-04-07 12:59:11	15	76	2538	22	318	3683	22	152.50	56	28.28	CHANGED	lhchps...hLs-hlh+..chshulhs..psPslhDLlcs-GAALhapsphhplGtTPscpplc-lspWLp.p..t.sss......shu.TDuLscs.YP.sAtslu-sssGhhAlpIo.ppch...lhWFRscssppVpWGGs.ccssphss...st+hpPRsSFcsahElV+s+SlPWcshEh-.....AhcsLphhLhsshh.cp.....ps	..........................................................................................................................IL+TQTlLCDMLLR.....DuP.l.u.IlT...QSPNlMDLV.KCDGAALaYc.sc......h........WhL.Gl..TP..o...E.sQI.+DIsp.WLhch......HssoT.............GLSTD...SL...h-A..GYP....uA..s..s..L.G...Du...........V.C.G...MAAs..pI..o....s......+...D..h........LFW.FRSHTApEl+WGGAK.Hc.P.t..-cDc............up+..M...H.PRoSFcAFlElV+.+ShPWp.........................................................................	0	89	180	254
+3857	PF03284	PHZA_PHZB		Phenazine biosynthesis protein A/B	Mifsud W	anon	Pfam-B_4020 (release 6.5)	Domain	\N	20.50	20.50	20.80	20.60	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.95	0.71	-5.15	8	88	2012-10-03 02:27:23	2003-04-07 12:59:11	8	2	31	21	8	134	0	153.10	69	98.67	CHANGED	Mscstssp.sFsDphEL..Rp+NRtTVEpYMcT+Gp-RLRRHcLFTEDGsGGLWTTDoGpPlVhpG+-+LAcHAhWSL+CFPDWEWaNV+lFET-DPNHFWVECDG+GKILFPGYPEGYYENHFlHSFEL-sG+IKRNREFMNPhQQLRALGIPVPpIKR-GIPo	..................................................................................M.spth.p.shpDt.EL..RR+NRAT.V.E+YMp.hKGt.-RL.pR.H.pLFVEDGCuG...WTT.-oGpPlVhRG+-pL.tc.hA.W....+C.....FPD.W..E.W.aNl+IFET-DPNHF.WVECDG+GKhLhPGYPEG.YhE..NHalHSFEL.Es.G+IKRNREFMNshQpLRALuIsVPpIKR-GIPT...........	0	4	5	7
+3858	PF00388	PI-PLC-X		Phosphatidylinositol-specific phospholipase C, X domain	Finn RD	anon	Prosite	Family	This associates with Pfam:PF00387 to form a single structural unit.	22.10	22.10	22.20	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.82	0.71	-4.80	140	2890	2012-10-01 22:17:21	2003-04-07 12:59:11	14	118	764	50	1401	2585	81	145.10	30	19.62	CHANGED	MspPLo+YFIsSSHNTYLsG.............................sQlt.....up.SSscsYhpsLppGCRClElDsW.......DGsss...p............................................................................................................P........llhH...GtThT...op..l.Fc-VlcsI+caAFhsS.p...........YPlIlSLEsHC.oscpQ..pphAchhpplhG-hLhspshst................ssstlPSPppL+tKILlKsKp	......................................................................................................s.Plo+YaIso..o...HN..oYLh.s.............................pQ.h.h.......u.p...opsp..sY......hps..L.....pt.GsRslE......l...D.s.a.........cus..cs....p..............................................................................................................................................s......hlhH........Gh...s...hs...................sp.l.....hp...-................Vl.c.s.Ipc...a.u...F..tss..p.....................hPl..Il..S.l...Es......+s.....s.p..pQ...p.t...h.....s..p...........hh...pp..l......aG-...h...Lhspshp............................ssptlPospp...L+tKIllps+.....................................................................	0	360	614	1002
+3859	PF00387	PI-PLC-Y		Phosphatidylinositol-specific phospholipase C, Y domain	Finn RD	anon	Prosite	Family	This associates with Pfam:PF00388 to form a single structural unit.	20.20	20.20	20.30	21.00	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.76	0.71	-4.11	86	1860	2012-10-01 22:17:21	2003-04-07 12:59:11	14	98	351	26	1049	1720	51	113.40	41	11.94	CHANGED	-LScLlsYspulp....FcsFpt.sppp....hhchtShsEspspphhc.pp..stp..hlcaN++pLoRlYPpG...hRl.cSSNa.sP..hWssGsQh..............VALNaQT.Dh.sMpLNpuhFp.N.......GpsGYVLKPshhR	...................................................................LSsLl.Yspss.p......ap.s....hp........pt.p..........t..................hhchsShsEsputchh........p..pp...............stc..al..p..aN..p+pLoRlYPpG...hR.l.DS...S.Na...sP..hWssGsQh..................VALNaQT.......sh..sMpLNpuhFp...N.......G..ps..G...YVLKPphh........................	0	250	418	726
+3860	PF02192	PI3K_p85B		PI3-kinase family, p85-binding domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	21.00	21.00	21.10	23.30	19.70	20.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.34	0.72	-4.56	13	271	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	91	6	146	207	0	76.20	47	7.94	CHANGED	hlplcVsppsTlppIKp.LWKpAcphPLaphLt-.suYhFsslNppApcE.ELpDEo..RRLCDlRPFhPlL+LlpRpssp	...........hlslcssRpAoLpsIKp..LW+cAcphPLap..hLp...-.suYlFssVsQ..p.AEpE..EhpDEo....RRLCDl+s.F..hPlL+llp+pGs.......	0	32	44	93
+3861	PF00794	PI3K_rbd		PI3-kinase family, ras-binding domain	SMART	anon	Alignment kindly provided by SMART	Family	Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly  significant similarity) to Ras-binding Pfam:PF00788 domains  (unpublished observation).	20.80	20.80	20.80	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.17	0.72	-4.10	12	588	2012-10-03 10:59:06	2003-04-07 12:59:11	13	31	130	78	323	502	1	105.50	25	9.04	CHANGED	ssp.hPcsl..hh.ssplhlslhhp..........ttp.shThpsssssostplhtphlpK...phshhpps-ssp........DalL+VsGppEalh.ssasLtpapaIppplppstpscLsLhp.st	..............................................s.....t.l...h...p..s.p.lhlslhhp..............s.ppshThpssssss.stplltpslpc.......ppsh...ht.ps.-.tt.............-YlL+VsGpcEYLh.s......c......as.Lspa.............p..a...IppClp.sp......cLhLhp...s...............	0	83	113	201
+3862	PF00613	PI3Ka		Phosphoinositide 3-kinase family, accessory domain (PIK domain)	Ponting C, Schultz J, Bork P	anon	SMART	Family	PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested [2] to be involved in substrate presentation.	29.00	29.00	29.00	29.20	28.80	28.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.20	0.71	-5.11	16	1353	2012-10-11 20:00:59	2003-04-07 12:59:11	15	53	314	96	849	1260	21	179.80	26	14.57	CHANGED	cchcs.sppc+cplcpIlshDPhspLotcE+phlWpaR.a.hlhshscALs.......KhLh.SVcWsshppsspshpLhtc...Ws...lcsscALELLsssass....hVRsaAVpsLEp.hsD-ELppYLLQLVQsL+YE.........................................................hpcShLs+FLlp+ALpNh.clGpFhaWaL+uEh......aspsh.spRFsslhEtahcsh.spthtpltp	..........................................................................................h.............l....l.h.t.h....s.........l.p....p-.pphlW.p.hR....h....hh.....p..............p.uLs...........................+hLh..s.s.p....a..pp..........p....p..s.t...p....h.............h.p.l.L..t..p......................W..s.........l.ss.p..A.LpL.Ls..s..p..ass.....h.............VRpa...AVppL.c.p..hs.c-c...LhhYL.QLVQ.A..L.K...aE............................................................................................................................................h.p.u.....sLscFLl....p.R.............Ahp.s...plu+hlaWh.L.....p...s-h.................cst..ph...t..p.h..t.lhpthhp...........hh....................................................	0	284	422	654
+3863	PF02226	Pico_P1A		Picornavirus coat protein (VP4)	Bateman A	anon	Pfam-B_345 (release 5.2)	Family	VP1, VP2, VP3 and VP4 for the basic unit that forms the icosahedral coat of picornaviruses. Five symmetry-related N termini of coat protein VP4 form a ten-stranded, antiparallel beta barrel around the base of the icosahedral fivefold axis [1].	20.80	20.80	21.60	21.00	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.30	0.72	-4.24	31	6859	2009-01-15 18:05:59	2003-04-07 12:59:11	11	25	444	79	0	4094	0	67.40	60	13.37	CHANGED	GAQVSTQ+oGuHETustAssGSoIsYTNINYYKDuuSsSAs+QDFoQDPuKFTcPVhDlhpcshPsLp	........GAQVSpQpsGoHEss..Ns.AosGSsIsYhNINYYKDuASuuAu+QDFSQDPSKFT-PVKDl.hpchhPsLp.........	0	0	0	0
+3864	PF00947	Pico_P2A		Picornavirus core protein 2A	Finn RD, Bateman A	anon	Pfam-B_138 (release 3.0)	Domain	This protein is a protease, involved in cleavage of the polyprotein.	21.00	15.00	21.20	15.10	20.70	14.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.54	0.71	-4.33	9	2140	2012-10-02 13:45:52	2003-04-07 12:59:11	14	29	270	3	0	2018	0	113.10	63	8.57	CHANGED	NhHLAT.pDapNslh.sasRDLLVsposApGsDpIARCsCsoGVYYCcS+pKaYPVshpsPshhhlcts-YYPtRaQophLluhGhuEPGDCGGILRCpHGVIGIlTAGGpGlVuFADlRDLhhlE-	....................................NRHLATpsDWpNsVWEsasRDLLVooT...sApGsDT.I.ARCs...CpoGVYY.CpS+pKaYPVSFpt....Psh..h....l.ptSEYYPtRYQSHlhlutGauEPGDCGGILR.CpHGVlGIlosGGpGlVuFuD..lRDLhhh--..........	1	0	0	0
+3865	PF01552	Pico_P2B		Picornavirus 2B protein	Bateman A	anon	Pfam-B_214 (release 4.0)	Family	Poliovirus infection leads to drastic alterations in membrane permeability late during infection. Proteins 2B and 2BC enhance membrane permeability [1,2].	20.00	20.00	20.20	21.70	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.26	0.72	-3.84	22	1455	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	271	0	0	1484	0	99.00	57	5.36	CHANGED	QG.loDYlppLGsAFGsGFTspIucplsplpshh..psslscKllKtllKllSALVIllRNpsDhhTVhATLALLGCsGSPW+aLKpKlCphhtl.Palp+Qu	..................QG.loDYIcpL....GsAFGo....G....FTs....pIs-pVs....t..Lpshl...........psslsEKlLKsLlKIISALVIllRN.ppD..h.s..T.lhATL.ALl.GCs...uSPWpWLKpKssphLtI.Phsp+Qu.......	0	0	0	0
+3866	PF00345	PapD_N	pili_assembly; Pili_assembly_N;	Pili and flagellar-assembly chaperone, PapD N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	C2 domain-like beta-sandwich fold. This domain is the n-terminal part of the PapD chaperone protein for pilus and flagellar assembly.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.55	0.71	-4.33	154	7954	2012-10-03 16:25:20	2003-04-07 12:59:11	15	5	993	92	559	3765	45	119.70	30	51.71	CHANGED	ulslssTRlIass..spc.psolplp.Nsss.tPhLlQsWl......-s.........tt......t.ptps.P......Fllo.PPlhRlcssppptlRl...hp..sss....LPpD...R.ESlFalNlppIPsts......................ps...plplAl+s+lKLFaR.P...suLt	..............................ulslssTRlIas.u..s.p.+...ps.slplp.Npss..psh.....Ll.QoWl..................-s......................tss.ppps.s............Fl.lo.PPlh.+lp.stpppplRl..hp....ssp.....LP.pD.R...ES.lFahNlcpIPsts..............p..p........spNsLplA..h..po+lKLFaR.Ptsl.......................................................	0	63	176	377
+3867	PF02753	PapD_C	pili_assembly_C; Pili_assembly_C;	Pili assembly chaperone PapD, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	Ig-like beta-sandwich fold. This domain is the C-terminal part of the pilus and flagellar-assembly chaperone protein PapD.	22.80	22.80	22.80	22.80	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.14	0.72	-4.14	155	6654	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	783	91	357	2906	15	65.10	26	28.05	CHANGED	lplpNPTPYalohssl.pls...........spplpss......MlsPhushphslssssss......plpaphINDaG.........uhsptpt	......lplpNPTPYYlols....s.l..pss..............sts.l.pss.......MlsPhust.shslssssss..............plpaphI..NDYG.........uhh....h........................	0	28	98	239
+3868	PF00114	Pilin	pilin; 	Pilin (bacterial filament)	Sonnhammer ELL	anon	Prosite	Domain	Proteins with only the short N-terminal methylation site are not separated from the noise.\	    The Prosite pattern detects those better.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.84	0.72	-3.34	147	1425	2012-10-03 10:38:27	2003-04-07 12:59:11	14	15	722	48	226	1319	90	110.70	23	71.92	CHANGED	ARuQloculuhhsuhKosl.Ehhhsp........Gphssssss.............hGhss.sss..ht.......shsssstsss.....................usIssshssssst......lsGpslslsts..ss..............................ssWsCss.......................sl.sscahP..s.uCp	.............................+uphspslt.hsu.hKsslt-hhhsp................Gth..ssssss..................hGhss...sss.hps.............Vpslsls..s........................GslTsshpssss........lpup.plsLtsp...ts...........................ssss.pW..t..Csss............................sl.ss...chh...PssCp....................................	0	58	120	168
+3869	PF05137	PilN		Fimbrial assembly protein (PilN)	Bateman A	anon	COG3166	Family	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.43	0.72	-4.15	214	1587	2012-10-02 17:03:51	2003-04-07 12:59:11	8	5	1422	0	398	1103	323	79.40	23	35.54	CHANGED	pllspL.sphlP.-s.lalsslp..hpss.......................plplsGhut......s.splushhcsLc.p........................................Sshhp..sspltshppss....................tttp.......htp............Fslpspl	........................hlppL.sp.hlP..-t..saLo..slp....h.pss................................................................................slplpGhup.........o.sslsshhps.Lc..p..........................................sshap.......ssphtshppps......................tps..............hhp............Fplpht.h.....................................................	0	129	253	341
+3870	PF04350	PilO		Pilus assembly protein, PilO	Mifsud W	anon	COG3167	Family	PilO proteins are involved in the assembly of pilin. However, the precise function of this family of proteins is not known.	21.80	21.80	21.80	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.82	0.71	-4.31	75	807	2012-10-02 17:03:51	2003-04-07 12:59:11	8	8	747	2	266	706	143	144.00	26	68.03	CHANGED	L...cptpscEppL+ppappKtppAsNLsta+pQhtpl-ppastlL+QLPscsElsuLLsDIspsGhssGLpFpphc.ts.Els..+-FYsElPIsIpVsGsYH-lGsFsuslAsLPRIV..oLcshslsss....pss..........tLshshhA+TYRah-	........................................................thptpEtpL+pph.pp..K..t...t...ps....s....sL..p....th.......c.....p.......Qlt...p..h...c......pph.......s....t.hl....c.......pLP....s.c.s....E.hssLLpcl..spsuhs......sGL...p.......h.pp......l......p.......t...............s.........p.h.s...............p.c......a............a..h.c.l.P.....l..slp..ls.G.sYaplup...F.sss.l..u...s.LsRIl..olcslslpts....spp.................ttLphphhApTYph......................................	0	94	174	231
+3871	PF04351	PilP		Pilus assembly protein, PilP	Mifsud W	anon	COG3168	Family	The PilP family are periplasmic proteins involved in the biogenesis of type IV pili [1].	21.20	21.20	21.20	21.30	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.54	0.71	-4.30	54	679	2009-09-11 22:48:09	2003-04-07 12:59:11	8	3	667	8	183	533	67	140.50	27	79.17	CHANGED	DLcpahscs+scspspIcPLPchpsapshsYsuss.hRsPF........sPhclt.......t.ttpspsslpPD.....hsRtK...EhLEsasL-sLpMVGol...s.pssthaALlcsssGslaRV+sGsYlGpNaG+lspIo-splplhElVsD.Gp.GsWlERsssLtLp	.....................................................Lptahtphctpst..l.tsh..........h.shsYps.tt..h+..sPF....................s....phh.................thttsssht.P-..........p.Rtc...psL..EpasL-sL+hlGsl..........s.p.s..sphhALl.p....ss...sup.lapVpsGsYlGpNtG+lspIs..c....splplhEhl..D.u.t.GsWhcR.spLtL.....................	1	48	110	154
+3872	PF04697	Pinin_SDK_N	pinin_SDK_N; 	pinin/SDK conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4141 (release 7.5)	Family	SDK2/3 is localised in nuclear speckles where as pinin is known to localise at the desmosomes where it is thought to be involved in anchoring intermediate filaments to the desmosomal plaque [1,2]. The role of SDK2/3 in the nucleus is thought to be concerned with modulation of alternative pre-mRNA splicing [4]. pinin has also been implicated as a tumour suppressor.  The conserved region is found at the N-terminus of the member proteins [3].	25.50	25.50	26.40	26.30	25.20	25.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.61	0.71	-4.13	2	80	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	51	0	41	78	0	126.30	73	20.63	CHANGED	MAVAVRoLQ-QLEKAKEuLKsVDENIRKLTGRDPs-lRPhQsRhLslsGPGGGRGRG..LLRRGhSDSGGGPPAK.RDl-GAl.RLuG-pRsRR-SRp-SDsE.DDDVKKPALQSSVVATSKERTRRDLIQDQs	.......MAVAVRoLQEQLEKAKESLKNVDENIRKLTGRD..P..NDl.RPhQ....ARlLu..L..oGP.G..GGRG..RGu..l.LL.RRGFSDSG.G...G..PPAK.QR..D.LE.G...AlS...RLGGERRTRRESRQESDsE.DDDV..K........K.PALQSSVVATSK.ER.T.RRDLIQDQN...................................................	1	10	12	22
+3873	PF00224	PK		Pyruvate kinase, barrel domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel.  The active site is found in a cleft between the two domains.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.06	0.70	-5.83	13	7047	2012-10-10 15:06:27	2003-04-07 12:59:11	16	29	4703	229	1953	5106	2651	326.30	42	68.66	CHANGED	hR+TpIlsTIGPu.................opoVE....pLpcLhcAGhNVsRhNFSHGoaEYHtssIcNVRcutcphut.......VAIALDTKGPEIRTGshps.....tlplssGcchhlosDtsh.tsssscchlalDYps...lscslpsGshIhlDDGlloLpVlphsssp.plhscspNsGslus+KGVNLPGscVDLPALoEKD+s.DL+FGVcp.s.VDhlFASFlRpAsDVpplRclLG-cG.+pIpIIuKIENppGV...sN...hDEILcsoDGlMVARGDLGlEIPA.cVhlsQKhlIuKCNhsGKPVIsATQMLESMhpNPRPTRAElSDVANAVLDGsDCVMLSGETApGpYPsEuVphMpclslpAEpulsphsla	...............................................................................++TKIVsTl.G....P.A.....................o.p.s.....-..hl.ppll.pA.G.h.NVhRhNFS.H..G..s.a......--Ht.pphppl......R.p.s.tp.p..h..u..cp...................lu..ILh..Dh.................p........G.........P.....c.....I...R..su......p..........h.....c............s.........G....t......................lpLpt.G.pp..h..h...l.......s........s..........c.............t......s..h......t........................................p..c.............p..l.u.l..s...Y..p.s.................l.s.p....Dl.......p......s.....G..s.....hl......L........l.........D.....D........G....hl...p..........Lp.....Vh...p..l....p..........s.................s...........p.......................l..................h.s....c...V..h.....s....u...G........L........u........s.p......K...Gl.......N.......l........P...Gs.....s..l..s.....l..PA..L.oEKD..pp.D.l.p..a..u..h..ct........s...lD.alAhSFlRpupDlt....p....l....R....c.....l.........l........c....p...............p..........G......p.........p..........l.........p.........l.l....uK....IEptE...ul...cN....hD-I..l.....c.....s.....o.....D......G.....lMVAR...GD....L....G....VEl..P......h....E...c.......V.shl................Q.........Kt...l...Ic+s.p..................p.h.sKsVITATQ..ML-S.......Ml...psPpPTR..AEsoDVAN.A....llD.G.TDAVMLS.uEo..AsGpYPlEuVpsMu.pI.s..hpsEp........t.....................................................................	0	656	1238	1641
+3874	PF02887	PK_C		Pyruvate kinase, alpha/beta domain	Finn RD, Griffiths-Jones SR, Bateman A	anon	Prosite	Domain	As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.	21.70	21.70	21.70	21.90	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.29	0.71	-4.54	173	6414	2009-01-15 18:05:59	2003-04-07 12:59:11	11	22	4576	233	1792	4498	1547	116.60	30	23.66	CHANGED	s-...ulutuAspsApc....ls.spuIlshTpSGpTAphlu+hRPs.hP...IlulT.ptp................st+pls.lhhGVhs.......................h...hhsptp.s.........s-chlppu.lch...............uhcpGh.lpsGD..hlllsuG...hstsG..sTNhh+lhp	..................................................................-uluh.uuspsApc......Ls...sp..uIlshTp.S.GpTA+..hl.S.+..aRPs....sP......IlAlT.scp...........................................st+p..ls..Lh..hGVhP.......................h.....hhc.phs..s...........................s-ph.hpt...u...hph...............shc.p.Gh..h......pp...G.D....hl.l.lsuG......s...h.....u....tsG......sTNhh+lh.h.............................................	0	593	1132	1494
+3875	PF02827	PKI		cAMP-dependent protein kinase inhibitor	Bateman A	anon	Bateman A	Family	Members of this family are extremely potent competitive inhibitors of camp-dependent protein kinase activity. These proteins interact with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.	25.00	25.00	30.50	30.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.62	0.72	-3.86	9	148	2009-09-11 05:02:57	2003-04-07 12:59:11	11	1	62	106	88	142	0	68.20	41	81.75	CHANGED	TDVEoshuDFhuSuRTGRRNAlPDI.s.SsAssso.u-LslKLutLsl.Ks-Gcpcspcssp-psscspsEu.p.c	........h-VEo..shu-FluouRTGRRNAlPDItu.SpAssso..s-Lsh+LusL.s.lpps-u..ptc...sppsspct.tpspspt....t....................	0	14	19	43
+3876	PF02173	pKID		pKID domain	Bateman A	anon	Pfam-B_1547 (Release 4.2)	Family	CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB [1].	25.00	25.00	26.10	26.70	24.40	22.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.19	0.72	-4.72	17	369	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	106	1	112	349	0	42.00	56	14.79	CHANGED	-s.uDuspssp++.R-ILoRRPSYRKILNDL....uupsssh.....ptpp	.........s-ultDSpKR.REILSRRPSYR........KILN-L....SS-ssuls....+h-............	0	20	30	61
+3877	PF03832	WSK	PkinA_anch; 	WSK motif	Griffiths-Jones SR, Bateman A	anon	Griffiths-Jones SR	Motif	This short motif is names after three conserved residues found in a WXSXK motif in protein kinase A anchoring proteins.	25.00	25.00	25.50	25.50	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.16	0.72	-4.60	12	161	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	35	0	78	190	0	31.00	42	5.82	CHANGED	pcshssWsShK+LVTsRK+s+ssscpcttps	...tcshssWsSFK+hVTsRK+s+sstcpcpt-.t....	0	4	9	23
+3878	PF00069	Pkinase	pkinase; 	Protein kinase domain	Sonnhammer ELL	anon	Unknown	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.65	0.70	-5.24	54	114309	2012-10-02 22:05:25	2003-04-07 12:59:11	20	4512	7677	2311	65911	134432	5368	237.60	20	40.43	CHANGED	aphhptlGpGuaGsV..apuhcpsssp........hhAlKhlptp.ptppptt.t.h....................Elplhppl.p....Hss..I..lphhshhps..................psplh..llhEahsss.....cLh.phlp................tpshl...scppspphhtpllpulpYlHs.p..........sllHRDLKspNILls.psspl...................KlsDFGlAp...................ttsss.thpshsGT.hYhAP....El....lt...............sptasttsDlWSlGlllhphls.....Gp......sPFt.sp........sphthhtphhtsthphs...............................................ppspcllpphLphcPpcRho.....sppllp+sah	..............................................................................................................................................................................p.l.G...p....G...s.h....u..................V................h...h.......s......h......................t.....t...t........................................h...A.....l...K......h.....h....p.................t........t............................t...........t................................................................................E..h...p...h.....h....t...p....l......p..............................H.............p..........l...........l......p.....h....h...s....h...h...t.p......................................................................tp.p..h..h.........l...l...h...E.......h........h..t...s.t...........................................s.L..h....p....h..lp.................................................................tt..t.....h...............s....t....p.....h.......h...............t......h.......h....h........p.............l...............h............p............u.......l........p....a.......l.......H...p...p.....................................................s.l.....l......H............R..............D.........l..............K..............P.........p................N...........l.....L.....l........s.....p....p...s..p.h....................................................................................+.l...s.......D.....F....G.....h...up...........................................................ttt..t.......h....p......s.....h......h........G......T....................h...........Y..............h..........u......P..............Eh..........h................................................................................t..t....t....h.....s..........t....s.......D.....l.........a...............u..............h..............G............h.....l....h........h.....p...h..h.t.......................u.p............................................s...a....st..................................................p......................h.......h..........t.......h..........h.....t..............................................................................................................................................................................................................................................t..h....p....h..h..........t.......h.....h.....t..............p.....s...t...p.....R.....s..................t...h...........................................................................................................................................................................................................................................	0	23780	38306	53856
+3879	PF00433	Pkinase_C	pkinase_C; 	Protein kinase C terminal domain	Finn RD	anon	Pfam-B_135 (release 1.0)	Family	\N	20.90	15.00	20.90	15.70	20.80	14.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.80	0.72	-3.44	160	3537	2009-01-15 18:05:59	2003-04-07 12:59:11	19	82	369	79	2010	3207	9	48.00	30	6.79	CHANGED	plputpDssNF.D.........p...cFT.pps.....................................................sthoss......s.thh..............................sshsp.......pp..FhGFoYsssp	.........lpu.pDssNFD...........p....-FT..pps.................................................................................................................................................sthoPs................ttpsl.....................................ss.sp.................pp.......FtGFoYss............................	0	477	765	1344
+3880	PF02253	PLA1		Phospholipase A1	Bateman A, Mian N	anon	Pfam-B_3500 (release 5.2)	Domain	Phospholipase A1 is a bacterial outer membrane bound acyl hydrolase with a broad substrate specificity EC:3.1.1.32. It has been proposed  that Ser164 is the active site for Swiss:P00631 [1].	19.70	19.70	19.80	22.80	18.30	19.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.91	0.70	-4.96	78	1227	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	1131	11	196	747	50	244.60	43	80.00	CHANGED	.uhlspchph-ptsp...pssaslpsa+sNYlLPhoas.sssNppshpst..........s.t..hcshEsKFQlShKhsl.hpslhs.t....sssLahuYTQpSaWQlYNp.p.SuPFRETNYcPElFhhhsss.....h...h.....hphphlslG...hsHpSNG+ussh..SRSWNRlYsshsacp.....s.sa..slsh+sWaRIsE...stpp.......D.DNPDIpcYhGph-lshsYths.cpphshhlRpNhp..sss+GulclsaoaPl........tspl+hYsQYFsGYGESLIDYNpcp.p+lGlGlsLs	.................................................htsh.......t..hppp..cssaslhsYcsNYll.as.o.sshNppshss.t...........sps.....t++sEsKFQLSlthsL....ac..s.l.lG........susLhhuYTQpSaWQl.Ns.cp..SSPFR..E...TNYEPplFlsassc.....aphs...hhshR.p..l..phG...hsHpSNG+.......o-Pp................SRSW.N...RlYsphhh-p.......G.sa..hlpl+sWahlsp....s........D.DNPDIs+YMGYaplpl..uYphs..-thl....o.h..phpaNh.........ssuaGusEluhoY.P.I.............spcl+hY..sQhasGYGESLIDYNapp.oRlGlGlhLs.................	1	39	107	161
+3881	PF01735	PLA2_B		Lysophospholipase catalytic domain	Bashton M, Bateman A	anon	Pfam-B_2127 (release 4.1)	Family	This family consists of Lysophospholipase / phospholipase B EC:3.1.1.5 and cytosolic phospholipase A2 EC:3.1.4 which also has a C2 domain Pfam:PF00168.  Phospholipase B enzymes catalyse the release of fatty acids from lysophsopholipids and are capable in vitro of hydrolysing all  phospholipids extractable form yeast cells [1].  Cytosolic phospholipase A2 associates with natural membranes in response to physiological increases in Ca2+ and selectively hydrolyses arachidonyl phospholipids [2], the aligned region corresponds the the carboxy-terminal Ca2+-independent catalytic  domain of the protein as discussed in [2].	19.70	19.70	19.70	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.57	0.70	-6.33	15	966	2012-10-02 11:19:24	2003-04-07 12:59:11	13	15	204	2	571	979	5	338.50	26	56.67	CHANGED	IulAsSGGGaRAMLsGAGhluAhDsRs.ssss...sLGGLLQSoTYluGLSGGsWLVGoLAhNNasSlpslhsp..tp.slWslspSlhs.P..tGlsls.pshphasslscpVppK+sAGFNlSLTDlWGRALSashhs.hppGGsuhTaSSlpssshFQsuEhPaPIhlADGRh....PGsslIslNuTlFEFoPaEhGSWDsolpuFssscYLGTplsNGsPl.pspClsGaDNsGFlMGTSSoLFNphLLp.lNoos.....hsshlppllpchLp.-hSpcps.DIu.Ys.sNPFp-ss.h.tpstos.........sIssscsLaLVDGGEDG..QNIPLhPLLpspRcVDVIFAlDsSs.Dscp.WPD.GsSLVsTYERpau....spu.puhuFPYVPDspTFlN.LGLss+PTFFGCDu+NhTsh....sp.sPPLVVYlPNs.aoahSNlSTFKhsYs-o-RpuhIpN.GFcuATpsN.p.DssFhuCVuCAIlpRp.EphNhotPspCppCFpsYCWNGTls	............................................................lulhhSGGGhRAhhshhG.hlhuhp........................sGlLpssoYluGlSGu.sW.h....h....u....olh.s..s.........h...s.....p..sl................p.............................................h.t......h..p..ps...........hhp................................h.............p.......p..h..tha................h.p....pltt..+tpt...G..h....hohsDhW..................G.h.h.l.........s..p.hh.....................................................t............t...................s.........h.........phS...s...p..................p.t.h.p...pup.PhPIhsu......th.p.............................s.s..............................h......t.h....t........p.........hhE.FoPaEhG...........ph...tuF.hshchhGoph....Gp...................................t............................p.....thh..........h..............Ghhhus.....u...h....s.......thh..................................................................t..h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..........................................................................................................................................	0	144	261	426
+3882	PF02988	PLA2_inh		Phospholipase A2 inhibitor	Griffiths-Jones SR	anon	Pfam-B_1254 (release 6.4)	Family	\N	21.70	21.70	21.80	21.80	21.00	21.40	hmmbuild  --amino -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.98	0.72	-3.55	5	85	2012-10-03 01:43:02	2003-04-07 12:59:11	10	2	45	0	26	94	0	82.30	38	41.96	CHANGED	+SCEICHNlG+DCsu.asEECuSPEDsCGTVLhEVSSAPLSlRolHKNCFSSSlCKL-aFDlNsGpEoYLRGRIsCC-c-cCEs	...............sCElC+s.hG.psCsG.hh..cpCsuscDsCsplh.hEloo.uslShpssaKsChoSshC+LshlssNhGpcsYlRu+hpCCpp-sCcs........	0	2	2	12
+3883	PF00321	Thionin	plant_thionins; 	Plant thionin	Finn RD	anon	Prosite	Domain	\N	20.50	20.50	22.80	23.80	19.50	16.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.19	0.72	-3.74	37	120	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	29	31	30	148	0	44.90	51	37.08	CHANGED	KSCCPoTsARNsYNsCRlsGs.spshCAshoGCKllSussCPssas.+	..KSCC.oTsuRNsYNsCRhsGs.upthCAslssCKllSG.sCPssas+....	0	4	5	14
+3884	PF01307	Plant_vir_prot		Plant viral movement protein	Finn RD, Bateman A	anon	Pfam-B_881 (release 3.0)	Family	This family includes several known plant viral movement proteins (e.g. Swiss:Q85292) from a number of different ssRNA plant virus families including potexviruses, hordeiviruses and carlaviruses. 	20.30	20.30	20.50	23.90	19.40	20.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.54	0.72	-4.31	78	326	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	133	0	0	321	0	104.10	33	92.51	CHANGED	LoPPPDao+shlssulGlululhlahls+..s.sLPpVGDN..lHsLPHGGpY+DGTKplpY.suPspt...........ttpssphhshhhllhLs.hhIah.sph..........ptptC.spCs	..LoPPPDhocshhshAlGluluhhl.ahhsp..s.pLPps.GDN..lHpLPHGGpYpDGTKpIpY.ssPppt.............tp.ss.ph.t.shhllllLs..hhIhhhspht.........ppppC..pC.h...................	1	0	0	0
+3885	PF04819	DUF716	Plant_viral_rep; 	Family of unknown function (DUF716) 	Finn RD	anon	Pfam-B_5106 (release 7.6)	Family	This family is equally distributed in both metazoa and plants. Annotation associated with Swiss:Q9SLW7 suggest that it may be  involved in response to viral attack in plants.  However, no clear function has been assigned to this family.	25.00	25.00	28.30	27.20	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.89	0.71	-4.74	32	388	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	80	0	247	370	0	128.40	27	44.55	CHANGED	hshuL...ppLhhuhAFh.EhhLFahHs.p........s+tulEsphH.LLlhslhlsshsshltlhhPpshh..lpLh+ushlhlQGsWFh.........................QhGFhLasP............................sstschc...tspccshhhlshpFsWalshshlhlsshYsh	................................................................h...slpplhhuhAhhhp.....hhLFhhHs..p........s..+tsl.-h.p.hH.LLlhslhlsslsshlclh...h..P..s.......s.hh............l..pl.h+uhhhllQGoWhh.........................QhGFhLasP................................hstsphc...psptpshhhlshtFsW....HlhhshlhhhshYs.h........	0	44	107	147
+3886	PF05015	Plasmid_killer		Plasmid maintenance system killer protein	Bateman A	anon	COG3549	Family	Several plasmids with proteic killer gene systems have been reported. All of them encode a stable toxin and an unstable antidote. Upon loss of the plasmid, the less stable inhibitor is inactivated more rapidly than the toxin, allowing the toxin to be activated. The activation of those systems result in cell filamentation and cessation of viable cell production. It has been verified that both the stable killer and the unstable inhibitor of the systems are short polypeptides. This family corresponds to the toxin.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.00	0.72	-3.84	8	1079	2012-10-03 00:18:00	2003-04-07 12:59:11	8	3	735	0	333	1012	133	89.40	31	94.60	CHANGED	MhhsF+cKsLcpFapcss..optIsushsc+Lpc+Lphl-sAps.pDLphP...uh+hc+L+G.chcsaaSI+VNspaRLIFpacsu.s.....ssllsYlD.H	...........................................MlhsFpc...ct.hppha...p....t.tp.....tpt....h......s..p.h..tpth.t.++LphLcsAp.s...h...pDLphPs.....u.+LctL.pG......c..c..p......G.aSI+l...Ns...p...aRlsFc.apss..s................sh.lph.DYH..............................	1	107	224	290
+3887	PF01672	Plasmid_parti		Putative plasmid partition protein	Bashton M, Bateman A	anon	Pfam-B_1163 (release 4.1)	Family	This family consists of conserved hypothetical proteins from Borrelia burgdorferi the lyme disease spirochaete, some of which are putative plasmid partition proteins [1].	22.10	22.10	22.10	22.10	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.68	0.72	-3.55	34	451	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	32	0	18	262	0	83.30	42	46.53	CHANGED	AYtYLKlApulp-GllppchlhEsGhppohphlcsccssshKKS+p..........N.IKPLRFQLKspESYDFYKpNuKFTuFlL-clFpspKD	........sYpYLKIApulp-Gllp.chlhcNGlppolphlcspp.s.pl+..KS+p..........N.IKPLRFQLKspES.YDFYKpNsKFTuFlL-clFpspK-........	0	17	17	17
+3888	PF05016	Plasmid_stabil		Plasmid stabilisation system protein	Bateman A	anon	COG3668 and [2]	Family	Members of this family are involved in plasmid stabilisation. The exact molecular function of this protein is not known. This family also encompasses RelE/ParE described in [2].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-10.17	0.72	-3.59	158	6528	2012-10-03 00:18:00	2003-04-07 12:59:11	9	12	2562	20	1504	5217	580	85.40	16	88.52	CHANGED	lthstpA..tpDlcclhchh............spphhpplppthpplt.ptsthscs.................h.thhphtht................sahlhYp..l......p.tthll.llplh+ppcth	...............................................h.hstpA..hc-lcclhphh...................tpph...h.pp.l...t..p.t.l.p.p.Lt....p.s.t.hspt.........t.........................h..sh.hc.h.t.ht................sahl.lYp.l..........ppsp.tl..l.l.lplhcppp.........................................	0	448	979	1251
+3889	PF00681	Plectin	Plectin_repeat;	Plectin repeat	Bateman A	anon	Pfam-B_68 (release 2.1)	Repeat	This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.	20.50	20.50	20.50	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.78	0.72	-4.43	119	3591	2009-01-15 18:05:59	2003-04-07 12:59:11	15	114	75	10	1456	3428	0	43.40	31	9.87	CHANGED	hpLL-uQhuoG.GllD.Ptssp+lolcpAhccGllstchtppLhpsp	.....................lLEuQhsoG.Gll.....D.Pt.....ss.....c.....+.lo.l.ppAhp+GllstchtptLhps...........	2	150	264	648
+3890	PF01523	PmbA_TldD		Putative modulator of DNA gyrase	Bashton M, Bateman A	anon	Pfam-B_845 (release 4.0)	Family	tldD and pmbA were found to suppress mutations in letD and inhibitor of DNA gyrase. Therefore it has been hypothesised that the TldD and PmbA proteins modulate the activity of DNA gyrase [1]. It has also been suggested that PmbA may be involved in secretion [2].	19.70	19.70	20.90	20.80	19.40	17.40	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.71	0.70	-5.14	158	5034	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	2139	8	1513	4013	3929	291.30	25	63.32	CHANGED	sts-l....hhp...p.spshsl.phpssclcphpp.spstuhulRl......hh....ss.+hG.husos...shsp.ps......lp.phlcpAh..p....hAc.......hspt......thtthsshsthsht...............hp.t..........htsh...shcc.......thchht.chpptstphttthhs.......sshspsppphhlhsSpGhphppppshhththpshsp......pssphpps.............ht.h...................tthsscpl.....ucpu....scpAhptl..s..upphpsGph.s..Vllsspssusllp.shs....pshpucplhps..pShh.....ts.......+l....GcplusptlolhDDPp...h.....suhuohsaDsEGlss.pcphll-cG.lLpsa	.................................................................................................................................u-l.hhpp.spstol...sh...c....pu..plcssph.....st-..pul.Gl.Rs.........................ht.............sp..+pG...hA....t......os.........slo....tu....................lt.pslpt..Ah..s.....................hA+....hsst................ttsshsshs.hshp....................hp.........h.sh..t..shcc.................tlclht.cs-ps.u.hs.t.-tclpps.......tuuhssthphhlhuso..c......Ghhs...s.php...shhplussllup.........csschcps...h..........shtshphh.....................t....sscth..................uccA........sc.p...A..lspL...s......utts.s...s..G.ph..s....Vlhusshs.....us.Llpcslu..p..ulpG.stsh+t.........sShh......ts..............pl.....Gc.p.l.s....s....p...h....lT..lh-Dsp..............l...........pthu.S..hsh............DsEG.s.ss..ppp..slIcsGlLpsa.....................................	0	444	903	1233
+3892	PF03332	PMM		Eukaryotic phosphomannomutase	Mifsud W	anon	Pfam-B_3713 (release 6.5)	Family	This enzyme EC:5.4.2.8 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.	20.00	20.00	20.20	20.10	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.37	0.70	-4.79	9	691	2012-10-03 04:19:28	2003-04-07 12:59:11	8	10	520	12	309	572	314	202.50	39	83.41	CHANGED	hc-hLp.cLRp+lsIGlVGGSDhpKhtEQLs...tcsVlscFDYsFuENGLsuY+tG+.lupQolhpaLGE-KlpcLlNFsL+Ylu-lDlPhKRGTFIEFRNGMlNlSPIGRsCSpEERp-FtcaDKp+pIRpKhVcsL+ccFs..chGLTFSIGGQISFDVFPpGWDKTYCLpHlEp-..FcsIHFFGDKTh.GGNDaEIasDPRTIGHoVsuP-DTlphlpElht.	......................................................................................................phlt..cLc.p..+.sslulVGGSDhs.KhpEQl...........tp......s..l..h...........p..p.a...D.....ahF..sENGhhhY+.sc.hh..p..ps.h....hphLG-.-.p.hp.c.h.l.p.asLph.h...u..c..l...p...l......P..h.....+.......R..G.sFl.E.hRs...GhlNlSPlGR.ssoh-ERpt......ap.p.h.D.KcpplRpphltsLppcFs.................ths..Lpash..GGpIShDVFPpGWDK..sY.s...Lpc...l.............p...p...p..........t.......h..p.pIaFFGD+s.....G..GNDYEIasp..p.s.hGasVssPcDThphhcpLh.....................................................................	0	99	159	241
+3893	PF03901	Glyco_transf_22	PMP; 	Alg9-like mannosyltransferase family	Finn RD, Bateman A	anon	DOMO:DM04662 & Pfam-B_7750 (Release 8.0)	Family	Members of this family are mannosyltransferase enzymes [1-2].  At least some members are localised in endoplasmic reticulum and involved in GPI anchor biosynthesis [3-4].	20.40	20.40	20.70	20.60	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.61	0.70	-5.48	16	1285	2012-10-03 03:08:05	2003-04-07 12:59:11	12	33	352	0	898	1337	89	359.40	19	69.81	CHANGED	hhahhhlshRlhsuhhsth...csDEhapshEsh.HhhlashGh.TWEap.phulRSaha......hlhthshhhlthhhtcsphhl............................................hhhsRlhhulhusls-hhlaphlspph......................................shpluphhlhh.lsshhhhhsuochhssShphhhshluLthh................................................hshhhlsshuhhtRPpusllhlPlshh.............hL..hhpphhpta........hhhslshhshhhh...slllDphaY...............G+hlhsshNhlpaNVh....sstsshYGscPaaaYhhsshsthshshhhhhlhushhh...................................hhsshhhhLhlaShhsHKE.RFlaPlh.Plhhlsuuhslsph.....................phthpth........hhhhhlhhhsslshuhhhulh+phGsh..h....chhstlppss.......t.s....slh...................lhtphaphPsphal.	......................................................................................................................h....hhh.hph.h...shhs..h.....psDE.....ap..-...sh....t........h....h.................h.........h........h....................s........h.................s..W.-a..........................s.l....Rshha...............................h...h..h...h...h...........h...h.....h....h.........h.h.....h........................h..h.....................................................................hhhsRh.h.h.uh...h.s.h.h.s....h....hhhp....h.t..ph.h....................................................s.....p..h..s...hh....h..h...hh.....hh..sh.....h.hhh...htoc...h...hss.shthh..hsh.huh.hh..h.....................................................................................................................................................t...hh.hh....h..h....shhu..h.h...h..t..s.....hh.hhh...sh.h.h...................................h.l.........hh.t..p......h.........................hh.h...s..h...h..h...h...hh........h...s.lhlDsh.a.a............................................................t...p.h..s..h......s....hs..hlhaNlh.......tstssha.G.......s..p.......Phh.aYh..hpsh........h.h.h....s..h...h..h..h..h.h..h..hhhh..........h.........................................................................................h..h..h.h..h.hs.hhh.h..l....hl..h.Sh..sH....K.E.RFlhP....hh.P..hl...h...l.h.u....uh....sh.t.h.h..............................................................................................................................hhhhh.h..h.hh..shhh...u.h.hhuh.h....p..ths.......................h........h......t.....................................................................................................................................................................................................................................................	0	296	484	741
+3894	PF00822	PMP22_Claudin	PMP22; 	PMP-22/EMP/MP20/Claudin family	Bateman A	anon	Pfam-B_1393 (release 2.1)	Family	\N	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.09	0.71	-4.59	13	2113	2012-10-03 00:20:40	2003-04-07 12:59:11	15	8	110	0	1175	2148	0	165.70	24	76.65	CHANGED	MhlhLhuhhlsplusssLLhloTl.sshWhlushss..................htsGLW+sCsssosssphssts.....t.pssLpAspAhMlLSl....IhulluhllhhhQhhshcpGscahl........uGIhhllusLClllusuIYTs+hssthtpsh......scacaGauahLuWluFshshluGllY	..................................................................................................................................h....hhuh.h.lshhuhl..sh.lh..s..ssh..s...h..Wh..hs.shh.s....................................................................hhapGL...WhsC...sh........p................u.......................s...............s.........t..h.....p.....C.......p........h...s...........s............h......h........s..........h.........s............s.............l....Q.........u.........s..R..u...L.....h..l....h..ul..............................llu..h..lu..h..l....l....s....h.....h......G....h....p.....C......h....p....t...s....p..p.ttsht..............................................hhhhuGl..h.a.l.l.......u..........G.lhs..l......l.ul...s..h......a.....s.......s......p........h........h..p..-......h...h....s..sh...................t.chch.........G.....huh.alGWsushlhhlu.Gsh....................................................................	0	109	224	589
+3895	PF01625	PMSR		Peptide methionine sulfoxide reductase	Bateman A	anon	Pfam-B_1111 (release 4.1)	Family	This enzyme repairs damaged proteins.  Methionine sulfoxide in proteins is reduced to methionine.	22.30	22.30	22.30	22.30	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.86	0.71	-4.35	66	6530	2009-01-15 18:05:59	2003-04-07 12:59:11	16	26	4318	25	1573	4711	3705	153.90	41	66.75	CHANGED	ppshhAGGCFWssEshFpplt........GVlpspsGYsGG..psps.PoYcpVsps......oGHsEsVclpaDPshloappLLchF..aph.aDPTphstQusDhGsQYRSuIahpsppQcphAcphhpphppp............hsptlsTplpsh..psFasA...E-YHQcYht+pspt..Ys..phhh	.......................pshhAGGCFWuhEphF.p.p.l.s.........G..Vh...sstuGYsGG......ps......t.N......Po.....Y...c.pV.ss....sp............TGH......sEsVclsa....DPph...l..........S..a..cpLLp.ha..a.ch...h..D..PT.......s...h..s....p..QG.s..Dh.G.sQYRo.uIah...p......s.....p.....c......Qcp.....hAcpshp..p.hppp.....................hpps.I..sT.E..l..............t......s.....h........p..s.......F.......Y....A.......E-YHQpYh..c..KNPpt..Yst..hh...............................................	0	508	1007	1340
+3896	PF02366	PMT		Dolichyl-phosphate-mannose-protein mannosyltransferase  	Bashton M, Bateman A	anon	Pfam-B_556 (release 5.2)	Family	This is a family of Dolichyl-phosphate-mannose-protein mannosyltransferase proteins EC:2.4.1.109.  These proteins are responsible for O-linked glycosylation of proteins, they catalyse the reaction:- Dolichyl phosphate D-mannose + protein <=> dolichyl phosphate + O-D-mannosyl-protein.\	  Also in this family is Swiss:Q94891 Drosophila rotated abdomen protein which is a putative mannosyltransferase [2]. This family appears to be distantly related to Pfam:PF02516 (A Bateman pers. obs.).	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.35	0.70	-5.01	22	2315	2012-10-03 03:08:05	2003-04-07 12:59:11	13	20	1595	0	896	3419	711	228.90	21	38.08	CHANGED	hhhtlhuhhsRhaplshsspllasEsphschtshYhptpaahss+..PPluphlluhshh.....lsshsssa.a.s.h.phhss.sshhthRhhsuhhusLsssLsYhhshphshsthsuhluullhhh-suhlT.u+ahLl-uhLlFFhshuhhshhph...............hotphhhhhhlsGluLGhulssK.hsuhhslhhlhhhshhplWphh......cpph.hh........................h.ahhsphhhLlllPhslalhh..ahlHhhhhh	............................................................................................h...hhhshhhhhhhh....h..s.....sh.....h..........sc.................h..........t.....Y....h......c....h..s.....h.............h..........hp..........s.hs...........hh..h.......s..hh...............h.h.t...h...s..........s.....s...h.......h.....a....h...ps....h....s......p......h...h...h.....s............h.........s....................h...u......h.R.h..h.......ss..hh....usl.s.ls.l.s......hh....hs..h.c.............l.....h.............t........s......p............h........s.........u.hl..A.u.l.lhh...h......p.....s...h.h.....h.....s.h.u..p.h..s..l..L...D...s...h...l..s...h....a.l...s..s.u.h.h..s..hhhhh.................................ptt..h....t......t....s....h........h.......h....h..h.....h..l....h..Gl.s..h.Ghu..h..hs.K...h...h....s..h...h....s..l............l.h...h..h..h....h....h.....s...h....h..p.t.h..h..................p.th.h...h.h....................................................h...h..h....h..h....h..h..h..L..l.l..l..P.h.h.l.hlh...h..th..h.............................................................................................................	1	277	520	754
+3897	PF03393	Pneumo_matrix		Pneumovirus matrix protein	Mifsud W	anon	Pfam-B_3641 (release 6.6)	Family	\N	20.80	20.80	21.90	51.30	20.00	16.30	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.47	0.70	-5.45	9	182	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	17	2	0	128	0	183.10	74	99.13	CHANGED	METYVNKLHEGSsYTAAVQYNVlEKDDDPASLTIWVPMFQSShPADlLIKELtslNILV+QISTPcGPSL+VhINSRSAVLAQMPsKFoISANVSLDERSKLAYDlTTPCEIKACSLTCLKsKsMLTTVKDLTMKThNPTH-IIALCEFENIhTSK+VlIPTYLRSISVKsKDLsoLENIsTTEFKNAITNAKIIPYAGLlLVITVTDNKGAFKYIKPQSQFIVDLGAYLEKESIYYVTTNWKHTATRFuIK	..........................................FQsshs.s.lhc.LhslTITTLYsASQsGPILKVNASAQGAAMSsLPKKFEVNATVALDEYSKL-FDKLTVCEVKoVYLTTMKPYGMVSKFVsSAKuVGKKTHDLIALCDFhDLEKshPVTIPAal+SlSl+pp-.solEshhosEhcpAlTpA+IhPYuGLlhlhThsssKGhFKhltstsQhIV-LGsYlptESl........................	0	0	0	0
+3898	PF03246	Pneumo_ncap		Pneumovirus nucleocapsid protein	Batreman A	anon	Pfam-B_3020 (release 6.5)	Family	\N	18.70	18.70	22.90	22.90	18.40	17.40	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.12	0.70	-5.94	4	663	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	24	70	0	329	0	129.50	46	99.85	CHANGED	MSLppl+LsDlp.KculLspSpYTIpRssGsoTulospslQpclspLCGMlLhTcascac.sApIGhQYhhotLGp-co.pILRsuG.cVpsVhT..Ksaol.hpGKphKhE...VLsIpulssuhhtslEhpARcohsphLKEtu.plPpNQR.sAPDsslIlLCIuALlhTKLAusscsGL-sslRRAspVLpsthpRYPph-l.cIAcSFYELFE+KsYYhslFIcaGhA.uSopuGS+sEuLFsslFMpAYGAGQsMLRWGVlA+SspNIMLGHsSVQAEhcQVsEVY-hspKhGsEuGhhHlRpsPKAuLLSLTsCPNFuSVVLGNAAGLGIIG.Y+Gps.NpELFsAAcuYAcpLKEsNhINaSuLsLTsEE+EAhpp.LNhsDDsspc	.....................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+3899	PF03438	Pneumo_NS1		Pneumovirus NS1 protein	Bateman A	anon	Pfam-B_3221 (release 6.6)	Family	This non-structural protein is one of two found in pneumoviruses. The protein is about 140 amino acids in length. The NS1 protein appears to be important for efficient replication but not essential [1]. The NS1 protein has been shown by yeast two-hybrid to interact with the viral P protein [2]. This protein is also known as the 1C protein. It has also been shown that NS1 can potently inhibit transcription and RNA replication [3].	20.50	20.50	21.70	266.10	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.85	0.71	-4.36	2	37	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	12	0	0	30	1	136.00	85	98.24	CHANGED	MGSpoLShIpVRLpNlaDNDcVALLKITCaTs+LIhLTpsLAKuVIHTIKLsGIVFlHlITSSDhCPsssIlspuNFToMPlLQNGGYIWEhMELTHC.QsNGLlDDNCEIpFSK+LSDSphspY.NQLSpLLGhs	MGsNSLSMIKVRLQNLFDNDEVALLKITCYTDKLIhLTNALAKAVIHTIKLNGIVFlHVITSS-lCPsNNIVVKSNFTTMPlLQNGGYIWEhhELTHCSQsNGLIDDNCEIKFSK+LSDSsMTsYMNQlS-LLGhD	0	0	0	0
+3900	PF02478	Pneumo_phosprot		Pneumovirus phosphoprotein	Mian N, Bateman A	anon	Pfam-B_2290 (release 5.4)	Family	This family represents the phosphoprotein of Paramyxoviridae,  a putative RNA polymerase alpha subunit that may function in template binding.	21.00	21.00	21.50	23.70	16.70	20.90	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.74	0.70	-4.87	8	859	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	20	0	0	264	2	99.10	76	96.37	CHANGED	PEGKDILFMGsEAAKhAEAFQ+Sl+psuptt.pSIsG-.lpT........luEplpLPslspss............osKsuppKssptsssslh...-lEplpEchlssss-sps.sscss-ossps.....KK+VoFcsscs...G+YTKLEKEALELLSD.pEDsD-ESSlLTFEE+Ds..ousSIEARLEuIEEKLSMILGhL+TLslATAGPTAARDGIRDAMlGlREELIscIhsEA.....KsKAAEhh+EE-sQRuKIGsGS.VKLTEKA+ELNKIlEDpSoSGESEpEpE....-sDtpt-DI	.........................................................................................................................................................................................................................................lREELIA-IIKEA.....KGKAAEMMEEEMNQRSKIGNGS.VKLTEKAKELNKIVEDESTSGESEEEEE.K-hQ-NNQt-DI.......	0	0	0	0
+3901	PF01048	PNP_UDP_1		Phosphorylase superfamily	Finn RD, Bateman A	anon	Pfam-B_1190 (release 3.0)	Domain	Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.13	0.70	-11.60	0.70	-5.39	159	15802	2012-10-01 20:25:13	2003-04-07 12:59:11	15	225	4828	837	4138	10648	3603	227.10	18	76.95	CHANGED	plullsuss............tchtthtpp.........h.ph.hhp..............tthphhhGph......tsttlslstpG.........h.Ghspss..hsshthlp..th.......................tsctllthGss........Gul....p.s..lp......sGDlllssp.....h.......lp.........hshtss....hh...................................................hhsshsth..hssplhphhtp..........htphs........................hplpp....Gshhsssuhhhps................tschp...hhpphG.......ss.....sl.-MEssshstlApph.s..ls.....hh.slpsl....os.............ttt..................pphtphhppstpphtpl..ltphlp	...................................................................................................................................................................................................hsllsu.s.............cht.hhp................htph...hs...................tshhhh.h.Gph............pup.p...l........s..l...h...t..sG.................h..G..hs.s.s....s........hhs.ttllp......th..........................................................ss..c...tl..l..t..s..Gs...s......................Gul...........pts....lp....................lGD....l..l..l..sps.........h.....................hp....................hssss.......h.h......................................................................................................................hh.st..hts....s....s....p...l.h..p...thhp................................sspphs.............................................................hphch.......Gshhos-shhhss............................................tphp..............hhpp.hu.....................sh.........sl..-ME.uusl.......s.t.s...u.tp....h...s.....l...........hh..slts.l......oDhh.t.............................................................ph.t...........................................................................................................................................................	0	1276	2469	3410
+3902	PF02233	PNTB		NAD(P) transhydrogenase beta subunit	Bateman A, Mian N	anon	Pfam-B_2220 (release 5.2)	Family	This family corresponds to the beta subunit of NADP transhydrogenase in prokaryotes, and either the protein N- or C terminal in eukaryotes.  The domain is often found in conjunction with Pfam:PF01262. Pyridine  nucleotide transhydrogenase catalyses the reduction of NAD+ to NADPH. A complete loss of activity occurs upon  mutation of Gly314 in  E. coli [1].	19.80	19.80	19.80	20.20	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.59	0.70	-5.71	10	2429	2012-10-03 09:55:27	2003-04-07 12:59:11	11	22	2140	27	707	1732	3888	439.00	53	87.05	CHANGED	sLhphsYls...uulhFIhuLtGLSspcTARtGNhhGIlGMsIAllATl..lssstsshs..................hlluulllGusIGlhIAp+VpMTsMPQLVAhFHSFVGLAAVLVuhAsaltppstuhsssu.............s.sshphlElaLGlaIGulTFTGSlVAFGKLQGlIsS+PLhLPu..RHhLNhuLLlssVllhlsFhhssshssthssLll..................uluhlhGhpLVhuIGGADMPVVISMLNSYSGWAsAAuGFhLsNsLLIlsGALlGSSGAILSYIMCKAMNRSlhsVIhGGFGsssusuuucs.t...sGps+psoA-EsA-hLhsApSVIIlPGYGMAVAQAQaslA-lschLcccGlpVRFuIHPVAGRMPGHMNVLLAEAsVPYDlVhEM-EIN-DFscTDVVLVIGANDTVNPAAp-DPsSPIAGMPVL-VWKA+sVlVhKRSMuoGYAGV-NPLFa+-NTpMLFGDAKKss-pllcpl	................................................slsshsYllAulL...FI...huLtG...LS...p.cTuRpGNhaGhh..GMul.AllAT...l....h..s..s..s...s...t..s..hs..............................h.l.ll.uhll...GGsl....G........hhh..A....++Vc..MTpMPpLVAhhHShVGLAAVLVuh.su...alp....t..s..h...s..h.h.............................................h.ss..hphsElaLGl..h.IGAlTFTGSllAFGKLpG.......p.....l.........s...u.....pP..l.......hL.Ps....+..H.hl...Nlsh....ll..s..sh.h.h..h..l.hF.s.........t..s....s...u........h...........h..h.s..L.hl.hs...........................hlAhshGhtllhsIGGADM...........P......VVlSMLNSYSGWAAAAtGFhLs..NslLIlsGA............LVGSSGAILSYIMC.....K.......AMNRSFlu.....VIh..G.G......F.G.....s...........s..s........s.....s......s................u...s...s...t...........................ttGp......h..+.p...ho.......A.......-..........-.s...............A.thL.....p.sApoVIIsPGYGMAVAQ..AQasVtElscpL+t.c.Glp.V..+FuIHPVAGRhPGH.MNV....LLAEAcVPYD...hVhEMDEIN...cD.FusTDVVLVIGAND.sVNPA.Ap-.DP.sSPI.uGMPV....L-VaKAp....sVlVhKRSM.s.oGY....................AGVpNPLFa.c.-N.Tp.....ML.FGDAKpsl-sllcu................................	0	215	421	584
+3903	PF03833	PolC_DP2		DNA polymerase II large subunit DP2	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	24.00	24.00	24.00	40.70	23.00	23.80	hmmbuild  -o /dev/null HMM SEED	900	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.62	0.70	-13.57	0.70	-6.88	6	125	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	111	1	80	138	362	805.40	45	69.80	CHANGED	ccYFEpLpcEl-+hY-IAcpARc+GhDPossVEIPlApDMA-RVEuLlG.pGlAcRIRELs.t-huRE.sALclucEIl-G+FGDhc...+Ecth-pAVRTALAILTEGlVAAPlEGIAcV+Ic+N..sDsocYLAlYYAGPIRSAGGTAQALSVLVuDYVR+tlGlDRYKPoE-EIERYlEEV-LYcptss.LQYpPos-ElRLsscNhPlpIsGEuT-csEVSGHRDLsRVETNplRGGhhLVLsEGll.KAPKllKYscplslEGW-WLcclhcusccu-...........t...pEEc.tlst...............ssDKalcDlIAGRPVFuHPS+sGGFRLRYGRuRNoGhAThGlpPATMaLls-FlAlGTQlKsERPGKAusVVPVDTIEGPsVKL+NGDVl+IsshpcAhcVRs-VtEIL.LG-hLlsYGDFLENNHsLhPAuascEWWIQpl.sus..........................tsDsctl+.........ts.s-pAl+huc-aclPLHPcYTYaWHDlosE-lchLtshltp..p.chpspc.....pchVL.lch.ppsKclLEhLGlsH+V+-splll-paaPhhtuLGhslppp.....phph.hpstpssl-hlNtluslcl+c+A.ohIGuRMGRPEKAc-RKM+PsVHsLFPIGpAGGupRsItcAsccsp.......shcVEluht+CPsCGcpohpphCPsCGoh.c............................sclcshs+pcIcLs-lhccAhcslGlpc..hDclKGVKGMhStpKhPEPLEKGILRAKp-VaVFKDGTsRFDsTDlPlTHF+PpEIGVSVEKLRELGYs+DhhGsELcc--QlVEL+PQDVIlscsuA-YLl+VAsFlDDLLp+FYsL-tFYNlKscEDLlGHLVIGLAPHTSAGVVGRIIGFocAssGYAHPYFHAAKRRN	.........................cYFcpLppclcchaclAccARppGhDPpscVEIPlApDhA-RVEsll........G................cG..VAcRIRE.Lt..pchu..+..E.....sALcluc-h.....s.....-GchGchs......+cpth-tAlRTAlAlLTE.GlVAAPlEGIucVcltcN..sDGo-YlslYYAGPIRSAGGTAQALSVLVuDYlRptlGlsca+P..p..-...-ElERYsEElpLYcptss.LQYpPps-El+hhscNhPlplsGEsT-c.EVSGaRDLpRV-........TNplRGGhhLVlsEGlhhKAsKlh+....as....c....p....lth-.uWs.WLp-llssptpsc.............................................t..c.....p......p.t..t..................................htsssKalc-lIAGRPVFuaPSc.GGFRLRYGRuRNoGaAosGlpPAoMhllD-FlAsGTQlKsERPGKAssVsPVDoIEGPhV+LpsGsVl+l-s......hccAhc...............l..+......spV-cIL.lG-hLlsaG-FlENNHsLhPuuYs.EWWhp-htpss...................................................hs.p.hp.............ss.ccAlchupchshPLHPcYTYhWcDloh--lttLtchlhp.......hpt.t..............................tp....l...l....p.......t..phKc....hLEhLhl.Hp.....h.....p..s.....pplhl..p..t..hs..hhhsLGhshp................................tht..t..........h...t...ss...psslchlNclushcl+p+AsohIGsRMGRPEKucpRcMpP.sspsLFPIGp.uGGspRsltcAsc.psp....................hpl-luhpcC..spCGp...ohhthCstCGspp...h.C..Ct........t..........................C.psthc.hpshpp......tplslpphhppAhcpls.pp...hc.lKGV+GhhSppKhsEPLEKGlLRAKpslhsFKDGTlRaDhTDlPlTHF+PpE.lslolE+L+ELGYpcDh.GpPLpp--QllEL+sQDllls................c.....s....sucYhl+supFlDDLL-+aYulp.FYsscpp-DLlGcLVhGhAPHTSAGllGRlIGFopAtVGYAHPYFHAAKRRN........................................	0	17	48	68
+3904	PF01620	Pollen_allerg_2		Ribonuclease (pollen allergen)	Bateman A	anon	Pfam-B_1050 (release 4.1)	Family	This family contains grass pollen proteins of group V. Swiss:Q40963 has been shown to possess ribonuclease activity [1].	25.00	25.00	77.70	26.60	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.09	0.71	-3.89	12	100	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	13	15	2	117	0	121.20	46	87.34	CHANGED	TVALFLAVALVA.....GPAASYAADuGYsP..............sssTPAssus....AuGKAT.T-EQKLl................EDlNAuFKAAsAAAAssPPADKaKT..FpssF.osusKu.lAstuo.........psstLssKLDsAYplAYcuApGATPEAKYDAFVuuLTEALRVIAGsLEVHAVKPAs	............................................................................................................................ttE.plI................-clsAuFKsAssAAsusPssDKFps..FEAuF.stu.Kt...........ssuu..uht............shphlPpL-AA.hK.AYsAssuAsPEsKYssF.AuLocAlpshuts.cV..s................	0	0	0	2
+3905	PF01190	Pollen_Ole_e_I		Pollen proteins Ole e I like	Finn RD, Bateman A	anon	Prosite	Family	\N	20.80	20.80	20.90	22.70	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.88	0.72	-4.15	91	693	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	68	0	380	702	0	93.10	23	40.42	CHANGED	VpGhVaCpsCpt..th.....sshsltGApVplpCcs....stt......thhtpuhTDppGhFp...ltl.t.s............tt.ptCpshLhso...Pps..sCshst.............uhpsupl	.......................VpGhVhCssCpt...shp.....tstsltGApVplp...Cpst......pst........hthptp.usTDpsGhFpltlss.s.................tttptCpspLh..so.....sps.......sCst.ts...........h.................................	1	40	199	290
+3906	PF00659	POLO_box		POLO box duplicated region	Bateman A, Mistry J, Sammut SJ	anon	Prosite	Family	\N	21.00	21.00	21.00	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.22	0.72	-4.00	81	913	2009-09-12 20:48:28	2003-04-07 12:59:11	13	8	221	70	585	888	4	67.70	25	17.34	CHANGED	aps+hulsapLSsusltV..FsDpo+lll.ssptp...tlpYls....p................ptppppashsph..........spplpc+lphlc	.........hps+hulsapLossoltV..F.s......DpT+lll..ssstp........tlpYls.......c.........................................ptpp.psathsp..............hsppLtp+lphh..............................................	1	224	294	444
+3907	PF02563	Poly_export		Polysaccharide biosynthesis/export protein	Mian N, Bateman A	anon	COGs & Pfam-B_1505 (Release 7.5)	Family	This is a family of periplasmic proteins involved in polysaccharide biosynthesis and/or export.	26.80	26.80	26.80	27.00	26.00	26.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.59	0.72	-4.22	183	3850	2009-01-15 18:05:59	2003-04-07 12:59:11	11	25	1898	24	1011	3117	920	91.50	27	23.26	CHANGED	sshsssssss..sYplGsGDhlplpVaspsc..............................................................sht......VsssGpIshPhlGslplsGhTssplppplpppLpp..hl...psP.pVsVpltp	............................sh......ts.pYplusGDhL....pl..s...V...a..s.psp................................L................................................s.s.......shh............VsscGsI.hh...P....h.l.G.p.lplsGhThsp...lpspIps+Lsp...hl......ps.P...pVsVpl..t...................................	0	301	639	825
+3908	PF01743	PolyA_pol		Poly A polymerase head domain	Bateman A	anon	Pfam-B_814 (release 4.2)	Domain	This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.	23.00	23.00	23.80	23.10	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.78	0.71	-3.92	21	6516	2012-10-02 22:47:23	2003-04-07 12:59:11	15	54	4623	24	1693	4940	3053	124.10	35	27.78	CHANGED	hYlVGGsVRDhLLG+ps...c.......DhDlsos.........AssppltphF.tpphhh.....Gtcathhplhhss..ph....lElAThRscp..tshts.pp.phs............ol--DhhRRDFTINAlhhs.....sssp....llDhhs.GhpDLcsphlR	..............................................................................................................hYlVGGuVRDhL...L...Gp.s........+...........................................DhDl.s.s.s..................................................up..P..c.p...h.p...p..h...h......p......psh.......h..................................G......h.......ca...t...sh..tV.h..h...ps...pt......................hEl.sT.hR...s...-p.t.......t..s....s..s..p.....p...s..ps..phsp.................................................................ol-.-Dh......tR......RDFTINAlAhs.......................t.s...s...p.............llD.a...s...G..h..pDLps+llR.................................................................................................	0	581	1098	1445
+3909	PF01518	PolyG_pol		Sigma NS protein	Bateman A	anon	Pfam-B_803 (release 4.0)	Family	This viral protein has a poly(C)-dependent poly(G) polymerase activity [2]. 	25.00	25.00	27.90	27.10	16.50	16.10	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.14	0.70	-5.97	4	145	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	59	0	0	124	0	334.10	58	99.39	CHANGED	MssolRluVSRssuGsuuQTlhpsahLLRssloscshpsshthQ.+FPshtpss+pLsPLtshstDRhl++ssltplhoR-hhhssDh.tphsacssshPho.sspuhphtcLlsshauEt...h-Hl....hPs.usoYsPuulA+hhohsMAGhsP.cG-shhhcssl.aLAA-LlsaphsLPYhls.lDGsosI.shPotsVEchLss.lutLsslDhSaGlEsRuDpRhTpDsupsSSRSlNEL.scEptt+h.shKlhLsh.shQLKlELDsLAcp+sE.pt.thlsuFGp+LFpQhShFusIDp-LhpLslhIKDpshths.tplhphWo.IRou.ucslssuuhslplcsGsWhltcG-DstLoVpPsRl	...........................................tshRhslS+.ttsssuQplh.NaYLLRCNISADG.RNAT+AVQuHFPaLSRAVRCLSPLAAHCADRT...LR..RDNVKQlLTRDLPFsSDL.INY.AHHVNSSSLT..TSpGVEAARLVAQVYGEQh.shDHl....YPoGStTYCPGAlANAISRIMAGFVPpEu-sFs.sGsIDaLAADLlsapFVLPYMls.VDGcsp.I.VlPot.TVEEMLss.suLLN.sIDASFGIES+SDQRMTRDAAEMSSRSLNELc-HEpRGRM.PWKIMLAhhAsQLKlELD...ALADpRsEsQuNAHVTSFGuRLFNQMSuFVsIDRELMcLALlIK-pGFAMNPuQlsuKWo.IRpS.usohshSuhplplctGpWhhhp.....................................................................................	0	0	0	0
+3910	PF00738	Polyhedrin		Polyhedrin	Bateman A	anon	Pfam-B_423 (release 2.1)	Family	These proteins are found in occlusion bodies in various viruses. The polyhedrin protein protects the virus.	25.00	25.00	71.90	71.70	20.60	20.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.34	0.70	-5.29	17	392	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	161	4	0	238	0	188.10	78	98.09	CHANGED	lGRTYVYDNKaYKNLGuVIKNAKRK+HhlEHEhEE+pLDsLD+YhVAEDPFLGPGKNQKLTLFKEIRNVKPDTMKLVVNWSGKEFLRETWTRFMEDSFPIVNDQElMDVFLVlNhRPTRPNRCY+FLAQHALRCDPDYVPHEVIRIVEPSYVGsNNEYRISLAK+GGGCPlMNLHSEYTNSFEpFlsRVIWENFYKPIVYVGTDSAEEEEILLEVSLVFKIKEFAPDAPLaoGPA	.........................................................LGPGKNQKLTLFKEIRsVKPDTMKLVVNWSGKEFLRETWTRFMEDSFPIVNDQ.E.lMDVFLVlNMRPT+PNRCYKFLAQHALRCDPDYVPHEVIRIVEPSYVGsNNEYRISLAKKGGGCPlMNLHSEYTN.SFEpFl.s+VIWENFYKPIVYlGTDSAEEEEILlEVSLlFKl....................	0	0	0	0
+3911	PF03364	Polyketide_cyc		Polyketide cyclase / dehydrase and lipid transport	Mifsud W, Mistry J, Wood V	anon	Pfam-B_1457 (release 6.6)	Family	This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. The family also includes proteins which are involved in the binding/transport of lipids.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.71	0.71	-4.15	95	3012	2012-10-02 19:24:03	2003-04-07 12:59:11	15	30	2234	27	1131	3986	1993	127.70	23	69.89	CHANGED	lshssp.plaslls.Dh...cpascahPhsp...........s..scllppsst........................................phphshtshpppa...sscsttphspp............................................ht.hpspWphhsht.............................................tstsplphphph..pht..hhshhhthhhpphhpphhpshp	....................................................................lshsscphaplV.s..Dl...ps...Y.PpF..l..Phsp...........................u..s...c..l.lppsss..........thhA.......................................................................pl.p.l.u.h...s..u..l...p.p..s..F.......so.c.s..p..h..p.spp.................................................................................l.h..p.h..h...s...G.....s..F...c...p...h....ps..t..W..pFps..hs.............................................................tsssclphp..l.ca........-..a..s..s..t...l..h...p.h...h..huhhhpchspphlpuF.................................................................................................................................	0	346	687	944
+3912	PF01736	Polyoma_agno		Polyomavirus agnoprotein	Bashton M, Bateman A	anon	Pfam-B_1917 (release 4.1)	Family	This family consist of the DNA binding protein or agnoprotein from various polyomaviruses. This protein is highly basic and can bind single stranded and double stranded DNA [2]. Mutations in the agnoprotein produce smaller viral plaques, hence its function is not essential for growth in tissue  culture cells but something has slowed in the normal replication  cycle [1]. There is also evidence suggesting that the agnogene and agnoprotein act as regulators of structural protein synthesis [1].	20.40	20.40	26.00	26.00	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.87	0.72	-4.33	3	130	2009-09-11 01:00:53	2003-04-07 12:59:11	11	1	5	0	0	117	0	58.10	81	91.17	CHANGED	MVLRQLSRQASVKVuKTWTGTKKRAQRIFIFlLELLL-FCcGEDSVDGK.RK+souLTEps-S	.MVLRQLSRKASVKVSKTWSGTKKRAQRIlIFlLEFLL-FCpGEDSVDGK.Rp+po.uLTppp.S........	1	0	0	0
+3913	PF00718	Polyoma_coat		Polyomavirus coat protein	Bateman A	anon	Pfam-B_748 (release 2.1)	Domain	\N	20.10	20.10	20.20	27.90	18.60	19.90	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.15	0.70	-5.51	12	3425	2009-01-15 18:05:59	2003-04-07 12:59:11	15	1	57	68	0	825	0	141.30	62	81.55	CHANGED	LLlKGGlEVL-V+TGPDShTpIEAaLNPRMGps.........tphaGFSpsIslusshssDsPppspLPsYSsA+ItLPhLNEDhTCsslLMWEAVSlKTEVVGloSLhNlHu.tup+s...sshGuuhPlpGhsaHhFAVGGEPL-LQGlhpNapssY....PssllsPp.....shsspuQV..LsPphKA+LDKDGtYPlEsWsPDPS+NENTRYFGoaTGGhpTPPVLpFTNTsTTVLLDENGVGPLCKGDGLYLSuADIsGhasppss.pQpaRGLPRYFsloLRKRhVKNPYPloSLLsSLFsshhPphpG	......................................................................................................................................................................................................................................................tsPPVLphTNTsTTVLLDE.GVGPLCKuDsLYlSAsDlCGhF.........TspsG.sQpWR....GLsRYFKlpLRKRpVKNPYPIShLLssLhN+hs.+VsG...................	0	0	0	0
+3914	PF00761	Polyoma_coat2		Polyomavirus coat protein	Bateman A	anon	Pfam-B_871 (release 2.1)	Family	\N	25.00	25.00	43.10	25.30	18.70	22.50	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.24	0.70	-4.93	8	383	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	41	1	0	366	0	225.50	48	91.94	CHANGED	GAsLolLhphlApVuElAuuTGhSVttIhuGEAhAsIEl...plAsLs.slE.Gl....sssuEAlAAlGLTspsaAllsut....P....sAl...uGh.......AAlh.QTVoG....uSAl...AssGhpaausWcHcVssVsL.tp.sMALplahP--.hDILFPGspoFsp.laYLDPh.+.WGsSLFpsVGpulW.c.lhRs......shspl..s..o..+-lptRTsp.lp.......-oLARaLEssRWslosuPlshYssl....psYYupLsslsPs.hRQlApR.h..hshG+o...slDpsDuhpthspch..-l..ppPp.sp..............SGpaIEKhtAPGGApQRsAPDWMLPLLLGLYGDlTPshcuacDp.ppcc+c	............................................................................................................................................................................................MALplapP--haDILFPGVssF..VNsl...pYLDPt.H.WGPSLFpoluQuhWp.llp-...........slstl..s..S..pElpcRTpchhh.......-sLARhLEpopWslsN...u...P.hshYshl..............p-YYucLs..sl.pPs.lRQl..Ap.Rctp.lshG+oa..slDpsDslpthspph..cl...cs.p..lp..............SGEaIE+shAPGGANQRsAPpWMLPLlLGLYGsVTPuLcuhE..DGsppKcc.R................................	0	0	0	0
+3915	PF00348	polyprenyl_synt		Polyprenyl synthetase	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	21.10	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.58	0.70	-5.54	16	11487	2009-09-13 10:32:47	2003-04-07 12:59:11	12	34	5158	295	3330	8899	6348	242.40	28	77.16	CHANGED	llttht.hhhtuG.KRlRPhlllhsuchlu.........hphsshhslAsslEhlHshSLlHDDl..MDsuclRRGpPTsHtpaGpssAlLsGDulhspAFphlsphp....h.sphphhtl.cLspsssspG.lt.QhhDlpst........chohcphhphhptKTutL.FtsusphuulhuGss..tctpcsLpcauhplGhAFQlhDDlLDhhusspplGK.sGsDlppsKsThsslhuLct...uppctppllcpshpp..pphshpshsth.tlcthtthhh	.....................................................................h....h..hh.h.h.s.G.G...K.RlRP.hls.l.h...s.s.p.h.hs....................................hp.t..p.t....h.....h.t.hA...s.u..lEh....lHs...hoL....l.............HD.....Dl........hD....ps.c..hR..R.Gp.s.....................T.........s...............p.................t.................t................a..................G...................p..........s................s.............A................l......LsG.D.......hL.....h...s....hA....ap.h....l.s....p.hs.............................p.........p.......h...h...t.....l.....h.....p.....h.......s..............h....s.......s...h..............s...........p.G....ht.....Qhh...c....h..t...s.t..................................................ph.s.h..c...p...h....h.p.l....h...pt....K...T..utL..ht........tu.sph........G.u.........l.....h......u............s......s.................s........t..........p........................h...............p.......t.....l....p....pa...u...pt.l.G..h.AF.QlhD...Dl.L.D.h..........h...u.......s......s..p............p.....h..G...K.s.s.....G.s...Dl.p........ps..K...Th....P..hl..h...u...hcp............up.t....t...t....t...t.....h...h..p...p.....t...........t..........................................................ht.......................................................................	0	1100	2096	2820
+3916	PF01943	Polysacc_synt		Polysaccharide biosynthesis protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family are integral membrane proteins [1]. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon [2]. The family includes SpoVB from Bacillus subtilis Swiss:Q00758, which is involved in spore cortex biosynthesis [3].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.75	0.70	-5.13	31	9954	2012-10-02 21:24:20	2003-04-07 12:59:11	12	25	3559	0	2091	9084	1735	278.40	14	58.36	CHANGED	lh+NhhhhhhsplhshllshlhhshluRhLuspsaGlhuhshshsshhshlsshGlsssls+plutsps.........phtsthhhsshhshhlhsllhhhhhhlht............hhshschshlhhlhhhhhh..hhhsss.hhshlhpuh.-phphhslpphlpplshhhhhhlhlhhhss.....lhhhshhhhhusllshllshhhhph.h..h...........hphhhht.hpth+phlp.uh.lhlsplssslhsthspl.hluhhhGsts........lGhYssuhplhhhh.tlhsshss.shhPhhuclh	.............................................................................................pssh.h.hhh.up.ll.s.h..h.l.u.h.l.h.h.h....h...h..s...p....h....l.......G.....s......p.....s...h.....G.....l...h...sh...s..hs...l...h...s.h...h....h...h...l....s...s.......h...G.....l....s....s....u....l....s....+.h.....l..u..p..hps.............................ph..h.p.....t...h....h......h....s.....h.....h.....h.....h.....h.....h.....h....h...s....l.....l....h.....h...h..h..h..h..lhs............................hht......t....s.....p.....h.....t..........h..........h.....h....h....h....h....s..h..shh.........h.h....s...h....h.......s.....h.........h.....p....s....h...h....p....u........h........p.......p......h.....p....h........h...s....l....p.......p.......l....h...t....p....l....h......t...l....h.....h....h...h....l....h...h..h.h..h.h..t...........................hh..t...h.....s..h..h..h..h..h..u...s...h..l.s...h...l....h......s...h..h..h...h...h...h.hh....t...........................................ph..t.h.............h...t....h....h.....p...p........h..h......p....h.....u....h.........h....h....l......s....s.l....s.h.....l....h....p....hl.-.p.....h....h.........l...s...t...h...h...sh.st..................................hG..ha....s..h...u.h...p.......l.h.t.h.h.h.h.h.h.sshhs..shhPhlst..h.............................................................................................................	0	663	1369	1745
+3917	PF02719	Polysacc_synt_2		Polysaccharide biosynthesis protein	Mian N, Bateman A	anon	Pfam-B_1536 (release 5.5)	Family	This is a family of diverse bacterial polysaccharide biosynthesis  proteins including the CapD protein (Swiss:P39853) [1], WalL protein (Swiss:O86159) mannosyl-transferase (Swiss:O05349) [2] and several putative epimerases (e.g. WbiI Swiss:O69130).	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.51	0.70	-5.52	77	3666	2012-10-10 17:06:42	2003-04-07 12:59:11	10	11	2439	14	813	25131	16928	278.60	42	55.79	CHANGED	lLVTGuGGSIGSEls+Qllph....sPpclllaspsEhshYplcp-...h...h.t.pl.......lGDVpDpcplppshpthpl-hVaHAAAhKHVPlsEh.NPhEul+sNlhGTtNlhcAAlpssVcphVhlSTDKAVpPsNlMGAoKRhuEhlh.Ahsppp......................TpFssVRFGNVLGSpGSVlPLF+cQIppG.GPlTlTcPchTRaFMTIsEAspLVlpAu..shucGG-.....lFVL-MGpsV+IhDLAcphl.cL.Ght..........DIpIchsGlRPGEKLYEELlhps-shpsppasclhtsps	.......................................................................................................................lLlTGuu.GS.I...Gu..El..s......+..p.l..h.ph...........s..P...c.......c.....l....l.......l.......h.......s..........+.........s.......E......h........s.......h....a....p......lp..p-........................l..........h..t...p...............l.....p....h.........................h....I..........u......D.....V...................p.............D.......p......p......p......l......p....p......s.....h.....c......................h.............p............s.....-.........h...........V...a....H....A....A.......A......h........K......H.....V......P........h......h.............E.......h.......N.....P.....h....E....A....l.....+....s........N..........l....h.....G........T....p..N........l.......h.......c...............A..............A.......h.........p...............s..............s................V..............c.................+............h.................V..............h...............l...............S.................T..................D.................K.................A....................V................p.................P................s................N...............l................M............G................A................o................K..R.....h....u.....E...h....l...h...u...h.spps.......tp..............................Tp.a..s..s.V..R......F......G....N.......V.......L.......G.......S.........p.........G..........S.......V........I......P....l....F....c...c...Q...I.......p....p......G.......u...P...l..T....l.......T......c....P.......c.....h.......T...R...a...F..M...T...l...s...E....A..s....p....L...V.......l...p...A.u........s...h...u.........c........u....G..-................l....F....V...h..c..M....G....p..s...l..+...I...h...D...L...Ac...ph.l...p.L..G............................-lp.I.c.h.s.G.l.R..........P.........G.EKLaEELlspp..E..t..hps.pphtchahh...........................................................................................................................................................................................	0	272	542	695
+3918	PF02530	Porin_2		Porin subfamily	Bashton M, Bateman A	anon	Pfam-B_1122 (release 5.4)	Family	This family consists of porins from the alpha subdivision of Proteobacteria the members of this family are related to Pfam:PF00267. The porins form large aqueous channels in the cell membrane allowing the selective entry of hydrophilic compounds this so called 'molecular sieve' is found in the cell walls of gram negative bacteria.   	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.36	0.70	-5.41	16	586	2012-10-03 17:14:37	2003-04-07 12:59:11	9	3	282	0	170	720	19	326.40	28	88.24	CHANGED	DAlVtAEPEPsEYV+VCDsYGsGaFYIPGTETCl+luGYlRhphshGs.....t...sh.ss.ssstpssastpoRhplphsTto-TEhGsL+sahchhhshssss...su..t........................................hslt.AaIpLGGh+sGpshShaDs.hlGhtuDslss.......spthNplpYpa-uGsuFsAulSl--tpusss................................hs...hsspssslVuuVcsstuhushpsssu.................aDs-hcpsAs+stlslp...susu.olhlsGsYusus..Y.........................................hsssp...................Wus.....huuhpapsssKsslssuhph.......................sshstatlGsslcYshlcslohps-lsYschsp.......................phpsp-slsGh	.....................................................................................................................................................Dh.lh.c..sh-YV+lCshaGsGaaYIPGT-TCl+ltGYlR..h..-s..t.h.ss................................s.h....s.s..p..t.pss..hst..tu..Rh...t.lphsot.opTEhG..s..Lps...ahph...ca.s...hs..sss.t..su............................................tts..htlphAalph...u....G...hphGhs.S.Fps..htu..h...s.s.slss...sh.ss.ssh...ps.s.p..lsYTashG.s.G...aoA.s...lulEpss..ssss.....................................................s.sh......h.ss.h.h.Pcllutlch..stuaG..uhthssA...........................................................a-s.....s.......h..p.t.....aA......s..p.s...tssls......lss.t.slhlpu..sYu..su..s...................................................................................................................................................................................................ssstp......................htt...W..ss.t..Wss............................au.uh.p...att.st+h...t.h.shthsh.....................................ssh..ttht.ss..ssltap.V.shshss-htYhp.hs....................................st.hsh...................................................................................................................................................................	1	38	89	115
+3919	PF01379	Porphobil_deam		Porphobilinogen deaminase, dipyromethane cofactor binding domain	Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	\N	22.10	22.10	22.70	22.70	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.42	0.70	-5.42	19	4004	2009-09-11 15:01:14	2003-04-07 12:59:11	15	21	3728	9	1153	3057	2572	207.30	46	65.99	CHANGED	pl+IGTRpSpLAlhQuphVhctLcphhPs....hph-lhhlpTpGD+ILDpsLuKlG...GKGLFsKELEpALLps.....clDlAVHShKDlPs.lPcGLhlusIscR-DP+DAll....pshpsLppLPpGullGTSSLRRpuQLttphPcLchcs.lRGNVsTRLpKL-ss..-aDAIILAsAGLpR...LGhpsclsp.....h.s-phLPAlGQGALuIEsRpsDpchhslLp	................................h.lpIuTRpS..LALhQuphVtstLp..tt..a..P.s.........................lpsEl.lsh.sT.pG.D...t....I....L....D..s..s.L.........u...+.......l.G............GK.G.LFsKELEpALLcs.......csDlA...VHShK.......D......l......P..s..t..h..P..pG.LsL.u.sls..cR.ED.....PR.DAhV.....o....................p.....s..............h......t..........s....Ls...s........L...P..........p....G..u...........l..........VGTSSLRR....p....s.......QLtt..........h.....R........P..........D..........L.......pl.p....s..l...RGNlsTRLpKL............c........sG...............-aDAIILAsA..GLpR................L.......G.h..p..s.....c....lpph.................lss-.....hL.......P..........AsGQ.GA....luIEsRts.D.pchhtlL.s.......................................................................................................	0	364	739	986
+3920	PF03900	Porphobil_deamC		Porphobilinogen deaminase, C-terminal domain	Bateman A, Griffiths-Jones SR	anon	SCOP	Domain	\N	21.30	21.30	21.40	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.62	0.72	-3.87	21	3787	2009-09-11 23:02:33	2003-04-07 12:59:11	10	15	3616	9	1082	2829	1539	74.20	34	23.23	CHANGED	thpshAERuhl+pLpGGCpVPIusauph.....tsp................lpLpuhlsssDGh........hhchptps.....t.pcutclGhclAcclhs	...........h.hpVpAERuhhppL.-GGCplPIuuaAplp......ssp................................................................lp.Lc..u.lVu.s.sDGsp...............hlcsphpG.............................s.pcucplGhplAccLl..................................................	0	334	692	920
+3921	PF00280	potato_inhibit		Potato inhibitor I family	Finn RD	anon	Prosite	Domain	\N	24.50	24.50	25.20	24.50	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.02	0.72	-3.83	60	372	2012-10-01 19:32:51	2003-04-07 12:59:11	13	2	66	54	144	396	2	61.90	42	75.93	CHANGED	KsSWPELVGhsuctA+tlIp+-pPslpsl.ll...sGos.VTtDa..cssRVRlaV...st..tsh.VspsPtlG	...........................KooWP.ELVGhsscpAc.ph.Ihc..-pPclpll..Vl....PsGoh....VThDa..cssRVRlaV.......st........sh..VspsPplG..............	0	20	82	119
+3922	PF00767	Poty_coat		Potyvirus coat protein	Finn RD, Bateman A	anon	Pfam-B_868 (release 2.1)	Family	\N	19.70	19.70	20.20	19.70	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.56	0.70	-5.09	33	6595	2009-01-15 18:05:59	2003-04-07 12:59:11	13	28	378	0	0	5499	0	218.30	55	33.96	CHANGED	+D+DVssGT.sGTFsVPRlKsls.sK.hplP+l+G+slLNL-HLLpYpPsQhDlSNTRATppQFpsWYcuVKp-Y-lsDp.pMsllhNGLMVWCIENGTSPNIs..GsW.....sMMDG-EQVEYPLKPll-pAKPThRQIMsHF.SDsAEAYIEhRNsccsYMPRYGLQRNLsDhSLARYAFDFYElTS+TPsRAREAHhQMKAAAlRssssRhFGLDGNVuTp-EsTERHTAsDVN+NMHoLLGs+h	..............................................+D+DVssGo.sG.phsVPRl..ct..h..opK.MphP..p.h.c.G.pslLN..L-HLlpYpPpQ...h.DluNTRATppQFcsWa-uV+t-Y-l.s.-s...pMsl.lhNG...L..M.V..W.CIENGT.S.P....slN..GsW...............sM..M..D....G...-...-..Q......V..E.Y.P.lKPll-pA..+...PT.....hRQIMtHF....S.DsA.E.A.YI.E.h.R.Nt.pc.sYMPRYGLpRNLpDhSLARYAF..DF...YEhs.S+.TP.sRAR.EAHhQ.MKAA.AL.+..ssps+.LFGLDGsVuopp.EsTERHTspDVspshHsLLGhp.s......................................	0	0	0	0
+3923	PF00157	Pou	pou; 	Pou domain - N-terminal to homeobox domain	Sonnhammer ELL	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.42	0.72	-4.33	20	1357	2012-10-04 14:01:12	2003-04-07 12:59:11	12	9	164	22	578	1331	1	69.20	59	18.40	CHANGED	c-ssshcELEpFA+p...FKp+RIsLGaTQuDVGhALusLaGss...FSQTTICRFEuLQLSaKNMCKL+PlLc+WLp-AE	.................c...ss.cELEpFA+p......FKQRR...IK.LG..aTQuDVGhA..Lu.........sLa.G.ss...FSQTTI...C.R..................FEuL.pLSFKNMCKLKPlLpKWLcEA-......................	0	111	158	327
+3924	PF05061	Pox_A11		Poxvirus A11 Protein	Moxon SJ	anon	Pfam-B_5994 (release 7.7)	Family	Family of conserved Chordopoxvirinae A11 family proteins. Conserved region spans entire protein in the majority of family members.	25.00	25.00	32.10	30.30	24.70	19.30	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.92	0.70	-5.36	9	62	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	43	0	0	49	0	290.10	58	99.77	CHANGED	MTslPVTDIsN...-YslTsFSEDsYPsNKNYEIToGQLSILRTVN-KL.....LA+TppspshpsDlspt........hhPs-DsPhoIlp+V.uPpssa.-sss.......llhuE..pQRppRlNIhhS.stEslIE+cslpp...tloSl.op..............TPSLGsVFD+-KRl+LLE-ElhpL+p+ps...psssNL-NFT+lLFGKsshcSsElNKRlsIVNYASlNpSsLThEDLEsCS-EEID+hYcslKQYN-ohKK+IlVTphIoIlI.VlEQlLVKLGF-ElKGLSsElTSEIIDlpIG-DCEtIAsKlGIuNSPlLNIslFllKhhIpRI+Ih	.........................................................................................MTTVPVTDItN...Dh.lT.pFSEDsYPSNKNYEIThtQhSILppVNshl.....hAhssSPp..phpSpls-s..................lhPD-DSPsTIIE+V.pPpTshlD.sssssp.....tEllluE..QQRppRhNIpVS.stEAlhEpcsh......IT.ShPop..............TPSLGVVa..DKDKR..IphLE-EVhpLRNppu.pocoSsNLDNFT+lLFGKsP.h+SoElNKRIAIVNYAsLNsSsLSlEDL-lCSE-EID+IYKsIKQYpESRK+KIIVTNlIII.lI.sIIEQsLlK.L.GF-ElKGLSo-lTSEIIDVEIG-DC-AlAsKLGIGNSPVLNIlLFllKlFV+RIKIl..........	0	0	0	0
+3925	PF04651	Pox_A12		Poxvirus A12 protein	Mifsud W	anon	Pfam-B_5523 (release 7.5)	Family	\N	25.00	25.00	45.40	38.30	23.20	22.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.44	0.71	-4.17	11	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	41	\N	0	60	0	182.20	63	97.69	CHANGED	MA-.KKLo.R..SSYDDYIETlNKlTPQL+TlLuHIuuEQusptsNhs....sssssss.pssuG...sssohp+op+soposspp......+.ss............SGAPpR+pss..hus.sc..psQ..hhQAVTNuGKIVYGTlK.DGKLEVpGpVGElNpDLLGI..ESVNAGRKs.o+up.............stpph..............puu....h+KtcshsssspshDh..GMs	.......MADKKNLAVR...SSYDDYIETVNKITPQLKNLLAQIGGDsAVKGGN........NNhsSQs-V.TAG...AssTKSKSoKChTs+sKo........pSoSo...............SsS+sS.p.oSGAP+RRTTs...ooS.hNA..hDGQIVQAVTNuGKIVYGTVR.DGQLEVRGMVGEINHDLLGI..ESVN.AGKKKsSKKh................PTsKK...........hshSSG....MRRpEpINssDsClDh..GM.h......................	0	0	0	0
+3926	PF04848	Pox_A22		Poxvirus A22 protein	Mifsud W	anon	Pfam-B_4558 (release 7.6)	Family	\N	21.00	21.00	21.00	21.10	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.82	0.71	-4.32	13	94	2012-10-03 01:22:09	2003-04-07 12:59:11	8	1	75	0	1	111	206	152.10	38	81.27	CHANGED	plICAhDlGsKNPARTllEl.ps........ss..I+llcIsKLDWS.ssWE+pVA+Dlsp....ashshVLLE+Qs+RSPasKFIYFIKGhLYs..opT+VIslsPs.....hsGsSY+sRK++SlclFLshhshFG..lss..lsch+KLDDVADSFNLAl+Yl...LsK	.............................................hIsAhDlGs+N.AhsllEs.cs.............ss.....l+..llDl......u..K.lc....ho.....pDa.c..+.pl.....s.+Dlsp.............hphssVLlERQP..cR.u..s..hl.+......h..l...a.FI.+..u..ah....h....p......s..s......s..KVIs.V..SPs..........................hsG...s.oY+-.R....K...K..pS.....V....Esh....hs....ahcs.as.......lpc....sl...s...cp.+.KhDDlADoashAhpal.......................................................................................................................	0	1	1	1
+3927	PF04584	Pox_A28		Poxvirus A28 family	Waterfield DI, Finn RD	anon	Pfam-B_4756 (release 7.5)	Family	Family of conserved Poxvirus A28 family proteins. Conserved region spans entire protein in the majority of family members.	21.40	21.40	24.50	24.50	20.70	18.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.30	15	68	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	47	0	0	50	1	139.50	60	99.61	CHANGED	MNslolFhIllATsAlClllFQhYslYENYDNIhEFNssHusLEYSKolss.stlDRpVaDPNDplaDsKpKWRCVpas.ssYVSlShFGF.pussusp....l+pFsTl-sClsaTFScuscusIaNPChsss..pSp-ClFLKSlL	..MNuLSlFFIVVATAAVCLlhlQuYSIYENYsNIKEFNAsHAAhEYSKSlGG.PuLDRRVpDsNDsIpDVKQKWRCVsYs.NuaVSASlFGF.pA-sGsN....IRKFsThppCIDaTFScshshcIaNPClsPN..sssECpFLKSVL....	0	0	0	0
+3928	PF04665	Pox_A32		Poxvirus A32 protein	Mifsud W	anon	Pfam-B_5586 (release 7.5)	Family	The A32 protein is thought to be involved in viral DNA packaging.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.68	0.70	-5.07	10	981	2012-10-05 12:31:08	2003-04-07 12:59:11	7	4	115	0	835	1034	176	165.70	48	66.54	CHANGED	Ep+FsRcSLLcsPFRMAlVGGSGSGKTsYLLSLFpTLVc+Y.KHIFLFTP....VhNsuYDuYlWPDHIpKVoopEE...LEYsLsssKpKIE+asp.upspK....t.pFLlILDDlGDhQhRS+sLlslhNaGRHlNlSlIlLCQTY+HVPlNGRsSITHaCCCNVS-SDlENhlRSMSI+GoKKpLl+slulhRuup.ppR+Vl.IIEDSVFspGEtRICYDoAD-pVltpclDhsILlsQFSHMKppLss	................................................................................................................pc.pphhpc++h+pcppp....................................................................................................................................................................IEhluK.KhQ.ua.c.........YP+R...sL.LILDD....F...A..S...H.h.K..s....R...-.Q....-...M.C.R.IL.K.....K...LR.HF.N..IS.VVICVQ.TA...KS..L.SKD.V.KR.IL.T..D.Il.L.F.P..s.h.scD..h.E.LMpESMusK.hc+cE.lWEtYKllps.......P+.oshcIH.IhsNpV........................................hlKst...............................................................................	1	782	794	835
+3929	PF04948	Pox_A51		Poxvirus A51 protein 	Finn RD	anon	Pfam-B_6937 (release 7.6)	Family	\N	19.90	19.90	20.60	20.60	18.50	18.90	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.11	0.70	-5.77	8	76	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	35	0	0	70	0	276.80	52	97.71	CHANGED	M-.hIlsss.Sh.+DhDll-alKssFssc..hspscNVCoKaDNllhoopoKsKllluDhPpIDpslSphYppsht..pslsRlSRFCKlltLcscKD.....alYlPtocsll..slLsIsppssssp....pCElphhsssspssI..pLp.scFsIlpss.pshhVKGsNllllIllF-EtsaPtIPLIRoISsNsVlISRHsRLHcElPscNWFKFYVEL+HsYoSuLhlllDGolLYAsuDYKTHChISKp.psp+c-lsDDCtCCYsssplplhsKp-llEpssCcsIRGGlpIplpcVGcFuASalGKYPNh-YIKIsluosYcMIsKQDplSGKptpusYlYGIA+R	..............................................................................................................................................................................................MD.lIVhslpuL.Kch.EplsalKNsFhhc...sptppsCcKlcNVhIsupoKssslIADlPhlDsulS-lhpohht..hsluRISRFsplIcl-cccc.......YsYhp..p-sls..sIloIu+ccD.........sCEllIsS.DpusssI..cLsph+hAILshs.sSFFsK...G.Nus.LlILLFD.hshsusPLLRS.losNsVlISRHpRLHcElPSpN.WFKFYlsl+psYCSlLYhVVDGSlhaAhADp+THshISKs.hhcsssINDECcCCYh-.PQI+ILDR-EMLsu..S..S.....Cchs..R+s..IhhsLs-lGcFGSSh..lGKY.EP-hIKI.ALSsutslIpspDhIsGR+taShYVYGIApR....................	0	0	0	0
+3930	PF04924	Pox_A6		Poxvirus A6 protein 	Finn RD	anon	Pfam-B_5792 (release 7.6)	Family	\N	19.70	19.70	20.00	19.80	18.30	17.70	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.43	0.70	-5.66	12	67	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	44	0	2	54	1	362.30	62	98.12	CHANGED	MDKLRslYp-FYpIS+cYLE+pTsppsssssa-sDVshhhslVPlLEpKlss.IssshoD-sllhhM+asNY+hFSFWFLKSsAVVKSVYN+Lcp-pE+p+FhplFKDlLlssQTLlSlNsMYpNlKQDTs-IVsDSKKIlEIVspl+sussEssAYKlLQsNaoFIVKTINKlLSDENYLLKlIAlFDocLloDK-KLpEY+ElFolSsESllaGI+ClS-L-lsolslp.NN..KYltFFKKlLuslILFQNssLsup+FlplVuKLYslIapphpTNspluhLlo-VLDSlKsKlSl--lKpcGVpNlQoLI+aIusN+s.YKsIlucEYhKREsslIcILQsIsscssIcasGpslDlctLlchhK-+ahp	..............................................MDKLRVLYDEFhsISK-pLERETGLosSDlDhDhDlsIFMTLVPVLEKKVCs.ITPoIcDDcIlsMMKYCsYQuFSFWFLKSGAVVKSVYNKL-.DsEKEKFlssF+DMLLNVQTLI.SLNuMYopLRQDTEDIVSDSKKIMEIVSHlRuSTsENAAYplLQpNNSFIlpTLNKILSDENYLLKIIAVFDSKLIS-KEpLNEYKpLaTISoESllYGIRCVSsLDISSVpLs...NN..KYVhFlKKhLPpIILFQNNDlNuQQFANVlSKlYoLIYpQLpoNV-VGsLLTDsl-SsKTKISVEcIKQsGINNlQSLIKFISDNKcpYKoIISEEYlu+EDcIIoILQsIlNEacIcY-spllNhR-LIshh+ERYu..........................	1	1	2	2
+3931	PF04745	Pox_A8		VITF-3 subunit protein	Waterfield DI, Finn RD	anon	Pfam-B_6036 (release 7.5)	Family	Family of Chordopoxvirus proteins composing one of the two subunits that make up VITF-3, a virally encoded complex necessary for intermediate stage transcription [1].	25.00	25.00	237.70	237.40	18.40	17.30	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.71	0.70	-5.48	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	39	0	287.30	66	98.14	CHANGED	MF-PVPDLNLEAolELGDVsI-sT+u+s+E..SsuYVSKsRRLFVH+SKD-ERKLALRFFLsRLYFLoYKElNYLFRClDsVKDVsITKKNNVIVAPYlILLTlSSKGYKLTESMIEhFFPELYNEsSKKFRFNSQIsIIQEKLGYssusYHVYEFEhYYSTVALALRsc+.....-s-lFNsRcESplVSSLSEITYRFYLIpLKSshVQWSuSTGoVINQlVNTVLlTVY-lLpKslpps+pFpCTLApEoclPlpLLlDRh-hFsKIIs-L++TNSFKISK+DKcsLLKYCp	.MF-PVPDLNLEAolELG-VNIDpTs.shl+E..souFlSRSRRLFsHRSKD-ERKLALRFFLQRLYFLsaRElpYLFRClDAVKDVoITKKNNIIVAPYIsLLTlASKGhKLTETMIEsFFPELYNEpSKKFKFNSQVsIIQEKLGYpsuNYHlYDFEsYYSTVALAIRccc.....sSs.IFNlRQEShLVSSLSEITYRFYLIpLKSDLVQWSuSTGAVINQMVNTVLITVYEhLphslcs.cspFsCoLAlESc.LPlcLL+DR.s-LFsKhIs-LK+TsSFKISKRDKDTLLKYFp.......	0	0	0	0
+3932	PF04835	Pox_A9		A9 protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4431 (release 7.6)	Family	Family of Chordopoxvirus A9 proteins. 	21.50	21.50	21.90	24.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.84	0.72	-4.06	8	68	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	1	53	0	54.00	71	55.25	CHANGED	AIDlhRHhFMYFCEs+lRPNSFWFVllRollSMlMaLlLGlsLLhISsNs-csc	..............AIDLCRHFFMYFCEQKLRPNSFWFVVVRAIASMIMYLVLGIALLYISEQDDKKN.....	0	1	1	1
+3933	PF04508	Pox_A_type_inc		Viral A-type inclusion protein repeat 	Waterfield DI, Finn RD	anon	Finn RD	Repeat	The repeat is found in the A-type inclusion protein of the Poxvirus family [1].  	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.54	0.74	-7.01	0.74	-3.68	27	453	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	22	0	1	343	0	22.90	49	16.96	CHANGED	cElc+h+p+Ip-L-cpLscspcs	.pElscL+sRIpDLERpLs-C+cs..	0	1	1	1
+3934	PF03286	Pox_Ag35		Pox virus Ag35 surface protein	Mifsud W	anon	Pfam-B_4295 (release 6.5)	Family	\N	24.10	24.10	26.20	26.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.48	0.71	-4.79	10	84	2009-09-11 15:09:14	2003-04-07 12:59:11	9	3	42	0	2	75	0	198.20	52	93.58	CHANGED	M.SWSINLu..uu.GDNFKTL-EIRAHVRSTTEssD..cssDDIFPs.....DI.................cIP.op+pP+pK+.....sTs.RK.......ssssKucKscKEKss.ttcc.psDs-K.............................TEENEs.sp..p-sscscpusSsssps......s-Ds.....................hDsSDLKlAT-sIlKDLKtLNsRVoAlSTVLEDVQAuSIoRQFTSLsKul-pL+slApsGKppVs..RKKs+s.sKK	..............M.AWSIo.p..us.oSSFpphsEIRAHLRsoA...ENpD......K.N-DIFPE.....DV...................................lIP..STcPKTKR.....sTsPRK......PAsTK+S..TKKtc-.+pplEE..E.....s...llEEhcp....sTEENSsssss..oPssGD.IsESlsAs-h-...........-.DssD-.........................poDhSDLKVATDNIVKDLK+IhoRISAVSTVLEDVQAAGISRQFTShTKuITsLucL.VopGKS.KVV..RKKVKo.CKK............	0	1	1	1
+3936	PF03336	Pox_C4_C10		Poxvirus C4/C10 protein	Mifsud W	anon	Pfam-B_3519 (release 6.5)	Family	\N	21.00	21.00	21.20	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.25	0.70	-5.66	8	127	2012-10-10 13:59:34	2003-04-07 12:59:11	8	2	33	0	1	132	15	260.00	52	96.81	CHANGED	hlplHlFo-shFcshKp-lh..lp..php......p.t..h.............pcSKplhhcsoLsc-lhspl+sl....lYcpLKslVc......sVpVcNclTllpY-+GDahsppps..ssshs+NtlshaLLlaLpps-pGGcs+lYlcssss.hlslooDlLFDKolsH-oppVcsGcKplAlhDVhlc..h..ccsllsTIcY.hsssIsLYD+EsDp.sLCYC-lp.Ipshs..s-hhphGlIsDRSGKClLVHpstclsphcc...lacSFp-lChpphh-.....tlhplppsss+sIAWSslc.sscsDpalPpsc-hYKhLpclss+p+s.ppt+l-hh...........shss---E.hahhCpVo+YYFsLPc	.........................................................................pTIKlFNp.EFDsIRN-lhpLhKhVp.......................................sss.l.pl.s...pD.s.D.I..-sIRcI....L.Y+phKN...Vc....................sl-lsssIoFhKYs...........N.ssl.....T....s.....s.h.t..YhLVIYLppsh...plKhh......aP.....Ts...p..........I.....p.o.s..........c..D.....IMFuKoLsF+.ppVhpshKhl.hhsISls.....Yp.ShspIpY..ssh...........IDIpssppsp.pLCYChIT.hDsHaL.lDlETlsVlVs+SGKCLLVNpahhhhhhpc...I.sSFsDlCMDpIF-h.spscELFoLpNDDsRNIAWDsDK.csssshWhPhT---YKFLS+Lh.hAK...ssThFDYY...........VLs.GD.T-PsTVF.FKVT+aYhNh..h.................................................	0	1	1	1
+3937	PF03287	Pox_C7_F8A		Poxvirus C7/F8A protein	Mifsud W	anon	Pfam-B_4089 (release 6.5)	Family	\N	24.10	24.10	25.50	31.90	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.80	0.71	-4.49	11	76	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	37	0	0	56	0	148.20	44	89.05	CHANGED	MGIpH-LDIalVsEslulKslpLhKGDSYGCsIclKlsspKplcFlllL+.PDWppIs-lKPIpMclNGhsl-spLl........................pcohhphIYsuslslpscos.lphaSDsccp.apctYPslpINs.KKhYclhcpGhThhaI-SPIsspDKhpahc	......MGIpHEhDI.lIsssIAL+NLpLHKGDsYGC+LcIISsshKplcF+hIl+.PDWSEIcclKsLpsasNshslcls+l........................ccohYhlIYpAslpLYscpTplLlaS..Ds-s-.aK+YYPhIsLNhhsKcYcVK-cNYossaIEaPllshcchp.hc...........	0	0	0	0
+3938	PF04701	Pox_D2		Pox virus D2 protein	Mifsud W	anon	Pfam-B_5832 (release 7.5)	Family	\N	25.00	25.00	66.70	66.50	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-11.02	0.71	-4.22	10	55	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	41	0	0	41	0	135.20	51	90.63	CHANGED	ch-lK+..LssI..ltNssllFssDlsplhsE+aIlLE+s.sGpshclHlYcssARFDN+oIa+lVKalY+sRsclL+llFPspshhESlcsLhPshTlsl...........pcsstss.hp...scs.ssKhlLLELFNSF+hGKsss...shPYYhLP	........phDIKK..ITDL..L.NusILFPDDV.pclLpEKYIVLERcsNGTPsssHIYco.hARFDNKSIYRIAKFLFhNRPDVIKLLF.....LEslEPLLPsKoINI..........ShssoEhPpL-....sPluTKlsLLELFNAFRoGtu-....PlPYYYLP....	0	0	0	0
+3939	PF00874	PRD	BglG_antitermin;	PRD domain	Declerck N, Bateman A	anon	Pfam-B_772 (release 3.0)	Domain	The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterised by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators Pfam:PF03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99, [2]) and inactive state (pdb:1tlv [4]), revealing massive structural rearrangements upon activation.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.89	0.72	-3.86	211	15913	2012-10-02 16:05:11	2003-04-07 12:59:11	15	106	2053	11	1448	9078	56	90.60	18	28.55	CHANGED	pcllphh.....cpphphph......ssthhhsLhhHlp..hslpR.lpps..........hphpsshh.pplcp.Y.sptaphspchhphlppph.shpls-sElsals.lHltss	..............................................t.thlphh.ppp.h...phph..........spthh.....sLhhHlp..hh...lp.R..lpps...............hph.p.s.s..h.h...p...p..l...p...p.......a.....spta.p...hs.p.p.hh.p....h....lpp....p..h....s.h....p..l.s.c.s.Elsals..lHhht..................	0	437	816	1106
+3940	PF04580	Pox_D3		Chordopoxvirinae D3 protein 	Waterfield DI, Finn RD	anon	Pfam-B_4684 (release 7.5)	Family	Chordopoxvirinae D3 protein conserved region.  Region occupies entire length of D3 protein.	19.90	19.90	20.30	20.10	19.60	18.60	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.61	0.70	-5.18	10	66	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	37	0	0	60	0	225.60	54	96.18	CHANGED	MDIhll+Dst.YPhhsscsNcs.FlLLGNHspFIsshLpclpp+..hhFascYtloPDchG.oLplchlsSSat..I+s+hVsV-EFIshGpshcWCspphpts....phscsDpllIaDIsahcsshWKRIlhlpCPshlssphEp............FlTNPa.lhppsp.......clF+NllLRStlNshIFs.psSsLcpLLsH.Ilophsl-+h..pslls...ac-sssl+LlppCY-Rs+F+AFVYAWFsuQl.sNsphENEKVc+sacpVpchI	...................MDIFI.VKDNK.YPKVDNDDNEV.FILLGNHNDFI+sKLTKLKE+...VFFS-YIVTPDsYG.SLCVELNGSSFQ..HGGRYIEVEEFIDuGRQVRWCSsSNHIS....cDhHTDKFlIYDIYTFD..uFKNKRLV.FVQVPsSLGD..DS............aLTNPh.L....S.......PYY+NuVARQMVNsMIFN.pDSFLKYLLEHLIRSHYRVSKH..ITIV+...YKDT-ELNLTRICYNRDKFKAFVFAWF......NGVsENEKVLDTYKKVSsLI..........	1	0	0	0
+3941	PF03288	Pox_D5		Poxvirus D5 protein-like	Mifsud W	anon	Pfam-B_4009 (release 6.5)	Domain	This family includes D5 from Poxviruses which is necessary for viral DNA replication, and is a nucleic acid independent nucleoside triphosphatase. Members of this family are also found outside of poxviruses. This domain is a DNA-binding winged HTH domain.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.96	0.72	-3.72	41	1059	2012-10-04 14:01:12	2003-04-07 12:59:11	11	32	639	6	337	979	69	91.70	20	16.60	CHANGED	pssDslh-Fhtphhs..............tu.hlPs.phlattYhpahccpGath.......LstppFppclsp.hhpt...s.....ahp++p+..................sthspthhphhhhp-h.s	...........................................................ps-shhtFht.h..........................................h..h.hsp..p.LYcsYhtahppp..Gats.......hohppFtpslpp.hhp.......t..........apc+p............................................................................................	0	258	294	317
+3942	PF04805	Pox_E10		E10-like protein conserved region	waterfield DI, Finn RD	anon	Pfam-B_6357 (release 7.5)	Family	Family of poxvirus proteins.	25.60	25.60	25.70	94.90	25.00	25.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.47	0.72	-4.45	11	59	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	43	21	69.90	74	73.15	CHANGED	slEtCK++LYsIssTLPCssCRtHApcAIpcNNlMSSsDlNYIYaFFIuLFNNLssDspa+.IDlpKVpPL	.NIEuCKRKLYTIVSTLPCPACRRHAThAIE-NNlMSSsDLNYIYYFFI+LFNNLASDPKYs.IDlsKV+PL.	0	0	0	0
+3943	PF04497	Pox_E2-like	Pox_E2;	Poxviridae protein 	Finn RD	anon	Pfam-B_3979 (release 7.5)	Family	This family of proteins is restricted to Poxviridae.  It contains a number of differently named uncharacterised proteins.	30.00	30.00	32.80	32.70	29.70	28.10	hmmbuild  -o /dev/null HMM SEED	728	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.09	0.70	-6.50	27	184	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	43	0	0	167	0	610.30	29	95.71	CHANGED	M...h..spplRcuhtphtsp....................phsaccLshpc..shpLlthGlH.spLPcphYscsl.chs.splhhFcPcpVphhDLlpllpppps.s..pphtstltaa+ppllppsshp.llp+hlphhhl.s-DDlch....llsc...t.hss.hLhplNsp.ltph..hhhScptlcplhpp.shphhshLYp+.s.hshphLhphhtcasIsPsNpulhp.p..shstsl-llpphsppp.......hlchlspplhsscphhphlh......IhtsplsshhshspcaLhsphsc............GlhsshhFs...........hspht..ptlocc..........phphIscaIshYchp..................uplhsph.c-hlpcphshtlh....pst.hlphhphshpsptshhtshp.sh--ll...........paLDsltlpsh.chphs.l..-.................hhhs.s.haN..spllc.hlpphuhsptKhptLhht..............hs.s.tshthhhphht..psshhhsst.hhsolh.h..............ht..t.hhhh...p...t..p.sh.ststpsphp.h..h.p..thph.hht........p.........................s.th.ss-scllsplaDlsphApaGll.hshhhhss.WhPlhshl........................phsphssssph.psslhpls.schscatsh........shst.lsshasthsshhsslhhYllsuhhh.....s.pp..thppFlppllsshhcGhtlt.........hspslpsss.p.hhclcphls.ts.ssh.hhhphhL+ssltlhccl	......................M..h..sp.hR+Ah.c..s+....................phshthlppcc..tlsLlchGhH.shLPKsLY.psl.p.s..plhhF.PchlsshDll.pslpp.p.p.s..-hhtshl.aHKsslhhsu.hs.llhhhh.Y.ll.ocsDlca..........lhpp....ss.hthhL.hINt..l.hh..hpho.sEIlsllpc.shhhh..lYpp.s.lD.chlhph.DcYsIsPlpsulhc.p..s.EhhIcllhthshsp.......hlshlsps.hhpsshhphIhs.....hhpt+lshhhshlp-aLpshh.D.......................sIhushhFp...................lshhs......lTts.............................E..alph.hshYshh...................................hp.hs...p.Dhlh.c.shpIs......poss.l.hhphP..hp..p.shlhp.p.ph.DIl...........palDphchso..chuh-sl..-.................hhho.ohhhN..ssllphhhhp.h.h.hhhhhLhh...............hshpp..sshhLpth...+Ghhhh.sh.slhoh.................h.h.hp..ph.....p.hpsc.lsh.sshppsh.h.hhphpul...............................................hsp-ctlh.plaDlsRhA.aGhh..s.hh.ps.WsPlsphl........................chp-hhs.t+..phsllslhsp..hchps.........ph..slss..AtlshhhsTll.Yllhs.hh.....slpp...sccFV.pllphhhcuhtl..........L.p.lpsss.h..pclc-hsspGs.ss..aLh+.plphh..lh-cl.........................................................................................................	0	0	0	0
+3944	PF04656	Pox_E6		Pox virus E6 protein	Waterfield DI, Finn RD	anon	Pfam-B_4392 (release 7.5)	Family	Family of pox virus E6 proteins.	25.00	25.00	25.70	195.00	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.73	0.70	-6.31	11	74	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	45	0	0	63	0	552.40	72	100.00	CHANGED	MDFIRRKYLIYTIENcIDFLRsElhsKlSNFoLNHVLAlKYLlhsFs+sVlTKDVLuNsNFaVFLHhV+CscVY-hVL+pSFDlPsLYlKuLlKNYshFschIpsYKphspcLl.Dc+FlElschusphp-lIGVNYDhtLNPLFHpGEPI+sMEIIYuKLFKKTcF++V+KlpVlRLLIWAYLoKpDTGhcFsDNDsQDlYTLaQKoGs.llpS-MTEpFKEYIFs..ss+TSYWlWLpEsIhNDsclYhctsApoMY-KlLSYIYSElKQGRVNKNMLKLVYlFEsDp.I+ullLpIIYGVPGDILSIIDo+DEsWKpYFluFYK-NFIDG+TFsSspoF.-DLF+VVA+IDPEYFDsc+.IhSlFcpcP-plchFDchDINsTYlSplIYpTpDlsLpslEchptCQIYN-DTcYaIKEYNTYLYLsE-DPhVl.cGhLsKLSsl.sps++..hoLFScsILKYYlDG+LAslGLVLssYcsDlll+lloHLKClEDVTsFlcausC+NsSllPSllRTILuNFNluIIlLFp+FLRENlaaVEpaLD+opHLTpNDKKYILplIppGRS	.MDFIRRKYLIYTVENNIDFLKDDsLSKVNNFTLNHVLALKYLVSNFPQHVITKDVLANTNFFVFlHMVRCCKVYEAVLRHAFDAPTLYVKALTKNYLSFSNAIQSYKETVHKLTQDEKFLEVAcYh-ELGELIGVNYDLVLNPLFHGGEPIKDMEIIFlKLFKKTDFKsVKKLSVIRLLIWAYLSKKDTGIEFADNDRQDIYTLFQpT.GR.IVHSNLTETFRDYIFP..GDKTSYWVWLNESIANDADIVLNRsAITMYDKI...LSYIYSEIKQGRVNKNMLKLVYIFEPEKDIRELLLEIIYDIPGDILSIIDuKNDDWKKYFISFYKuNFINGNTFISDRTFN-DLFRVVVpIDPEYFDNER.IhSLFSTSA.s-IKRFDELDINNSYISNIIYEVNDITL-TMD-MKKCQIFNEDTsYYlKEYNTYLFLpEsDPMVI-NGILKKLSSIKoKSRR..LNLFSKNILKYYLDGQLARLGLVLDDYKGDLLVKhIsHLKsVEDVSAFVRFSTcKNPSILPSLI+TILASYNISIIVLFQ+FLRDNLYHVEcFLDKSlHLTKsDKKYILQLIRHGRS.	0	0	0	0
+3945	PF03394	Pox_E8		Poxvirus E8 protein	Mifsud W	anon	Pfam-B_3759 (release 6.6)	Family	\N	20.50	20.50	20.70	89.40	20.20	16.80	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.68	0.70	-5.00	8	66	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	41	0	0	52	0	236.70	77	85.75	CHANGED	h+NTYLYHNYAYGWIPETAlWSSRaAsLDlTDYYPITLGLLKKFEFMhSLa+GP...s.sYpsKINTEFlupGSFhGRalsaa++FoILPTcEFISFLLLTSIPIYNILFaFKsTpFDhsKHoLFuuhYosss+HlELA+Yh++uGDYKPLFu+Lc-..cslYo.....u...shPlshtsll+spsPsu.p.ssS.DYETLANLSAILYaTcYDPVLhFLhFYlPGlSVTTKITPuVEYLMcKLsLsKcDVsLl	MKNTYLFDNYAYGWIPETAIWSSRYANLDASDYYPISLGLLKKFEFLMSLYKGP...IPVYEEKVNTEFIANGSFSGRYVSYLRKFSALPTNEFISFLLLTSIPIYNILFWFKNTQFDITKHTLFRYVYTDNsKHLALARYh+QTGDYKPLFSRLKE..NYIFT......G...PVPIGI+DIsHPNLSRA.R.SPS.DYETLANISTILYFTKYDPVLMFLLFYVPGYSITTKITPAVEYLMDKLsLTKsDVpLL.	0	0	0	0
+3946	PF04943	Pox_F11		Poxvirus F11 protein	Finn RD	anon	Pfam-B_6911 (release 7.6)	Family	The protein F11 is an early virus protein.	24.10	24.10	24.10	24.20	20.30	24.00	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.06	0.70	-5.60	7	107	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	36	0	1	85	0	197.40	38	88.29	CHANGED	o.tphss......hslp.p............Phhhlspussp.l....Lhsslalp..slcslhspsstllscssphpp.s..p..apht.l.l.sshhhchlhDtpsaFcls-shll+LcHGshahptshasssshuFsAlICl+NpGhSulhVsposhlppshppGssllhRSspulphLPQIuGcuhYLIlplsPTcchhcphh.slhssspspsu.........p.phthsuppc+cshchlsslIphpl.LEchhhchs....hhpEhtshYsslhh........................................pppppp.lpshhppscshhppuhssh.hh..........tpsspssh+cchLhtthp.+Dlp.lhsshsp...............laschtclhpclsshls..................tps-hlppaIhthlspspssh.psplhpsL.....hslsslsahl	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+3947	PF03337	Pox_F12L		Poxvirus F12L protein	Mifsud W	anon	Pfam-B_3082 (release 6.5)	Family	\N	25.00	25.00	87.60	87.40	24.50	17.70	hmmbuild  -o /dev/null HMM SEED	651	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.27	0.70	-6.61	11	87	2012-10-02 01:06:00	2003-04-07 12:59:11	8	1	43	0	0	83	0	615.20	60	99.36	CHANGED	shhsplpssss..t....plsssLpch.chsllLA+spcGKGlllhusNlptspsh...lslopLcllulsthl-shssPstPhspLhIsuh-o-.saYSPcTSpo.PLlDIL++Ruppps..-LtpAl.tc.hs.pussSloEINpWhspsGLt+YRFlsacDt+thph....sphTllD-MsIsaIGpHhIWVKDh.sYsRPElDI.LsaDlcsluptspWucl.pshstphhplhuhhlpuhlos..sGPplYMIoTY.PG+sFhshsSsK.Llp-FLcWlp-.hhtshp....................TlsLlGahSSlFDhPLL+ssasps.pGWshl....usssllScsGh+lhllDhupFuhuh.olp-YCpaWsusshshscD..llocpEs+hphchlccsuscsspsLasAshsppssLsplhsssshhtFssL-DMllspuhhhuApp.stthYhPstssshshlppulptctVpoh..ssss..t.hppa+L+SllclltsphYPlG+PpaVpp.hscGKLYIALCcVTh+ssl+IPllassc.sEsshoF.ssLTSVDIphAt+lGGYpI+.lsALpW-cShpl.+sslpchhstlscl...spospLhsplsp....scLh.pspss.hsp..hl..atAFAASYCRtplHslIcclDSHalGsaVh+HsYpclalpsssststshLSphhcl	..........................................................................s...QhLMKTAN......NYETIEILRNYLRLYIILARNEEG+GILIYDDNIDSlMSM...MNIT+LEVIGLT.HCTKLRSSPPIP...MSRLFMDEIDHE.SYYSPKTScY.PLIDIIRKRSHEQG..DIALAL.E+.Y.sIEN..TDSISEINEWLSSKGLACYRFVKFND.Y.RKQhhh+.ho+tTIVDSMIIGHIGHHYIWIKNLETYTRPEIDV.LPFDIKhISRDELWARI.SSSLDQTHIKTIAVSVYGAITD..NGPhPYMISTY.PGNTFVNFNSVKsLILsFLDWIKD.IM.TSTR....................TIILVGYMSNLFDIPLLTVYWPNN.CGWKIY.....NNpLISSDGARVIWMDAYKFSCGL.SLQDYCYHWGSK.PESRPFD..LIKKsDAKRNhKSlVKESMsSLKSLYEAFcTQSGALEVLMSPCRM.FSFSRIEDMFLTSVINRVScNTGMGMYYPTNDIssLFIESSICLDYIIVNNQcS.....NKYRIKSVLDIISSKQYPAGRPNYVKN..GTKGKLYIALCKVTVP.TNDHIPVVYHDD..DNTTTFITVLTSVDIETAhR.AGYSIVELGALQWD-NIPcLK-..sLLDSIKhIYDL.NssTTN....NLLEQLIE............N.INFNNSSII.LFYTFAISYCRAFIYSIMETIDshYISQF....SYKELYlsSSaKDINEsMSQMVKL...................	0	0	0	0
+3948	PF04596	Pox_F15		Poxvirus protein F15	Mifsud W	anon	Pfam-B_5182 (release 7.5)	Family	\N	25.00	25.00	167.60	167.30	16.70	16.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.85	0.71	-4.58	11	51	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	38	0	0	33	0	136.20	68	88.25	CHANGED	LsPF+sMs+IKINpc-NClLGNRCFVKlscV+ahPpsuls....Topolph+sacFTLsELLYSPFHFpQsQaQYLhPuFVLpCI-EAs+NpppC+YChss+ssc..suLNINIFlPThspphYlIIGLRIKsFWsssFcIE	M+PFKNMNKIsINpcDNCILANRCFVKIDTsRYIPssSIs....oSshIRIRNHDFTLSELLYSPFHFQQPQFQYLLPGFVLTCIDKsoKppKcCKYCISNRGDD..DSLSINlFIPTINKSIYIIIGLRhKsFWKsKFEIE.	0	0	0	0
+3949	PF04708	Pox_F16		Poxvirus F16 protein	Mifsud W	anon	Pfam-B_5863 (release 7.5)	Family	\N	25.00	25.00	25.40	33.50	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.49	0.70	-5.06	9	65	2009-09-11 09:28:37	2003-04-07 12:59:11	7	1	39	0	0	56	0	212.30	56	91.97	CHANGED	cpAAIlTSLlSLFDsSlpaQlchC+pYCp.LuhpVlhEl+EFGYIs-csLpocpW.ssltsssIshlVFYQlKQLoISscpLYshhh+.sc.ssl+lYFV+DsLsFDG..hPPoF+plshslphtsRKKl+DlIsLlshpTsscpllpcFlpsNFGsVctLLpllcpssLWlphhLsppcp+t..................hshhpa+pFlsKl+clct.hpsp.l-cICsshpsIsl	..............M.KVVIVTSVuSLLDASIQFQKTACRHHCNYLSMQlVKEI-EFGTINEKNLEFcTWKDVIQNDEIDALVFYRVKQISISsGVLYcSMMR.NRTKPISMYFVRDCLAFDG..sPPSFRMTSCNINAYNRsKIKDLIIL.MNMKT.CNKKIIGEFIIDNFGSVcuLLSIINSNVTWVTSVINNSNGRGINIRVS........NNKMLTITSFRRFVNKLKhYKTTKCsSQLDNLCT-hNKMcI....	0	0	0	0
+3950	PF04767	Pox_F17		DNA-binding 11 kDa phosphoprotein	Waterfield DI, Finn RD	anon	Pfam-B_6128 (release 7.5)	Family	Family of poxvirus proteins required for virus morphogenesis. Protein function necessary for proteolytic processing of the major viral structural proteins, P4a and P4b [1]. 	25.00	25.00	32.90	32.20	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.27	0.72	-3.74	11	57	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	37	0	95.10	63	94.23	CHANGED	hhhcoPFhlsTc.EGRYLVLKAlKlCslRTV-Ccus+ASCVLKVEKP.susC-R..ssoPs.Rstht.......osPs.+sssplPFMRTNhLpsl.usNR.NssuRlLu	.u..AHTPFYINTK.EGRYLVLKAVKVCDVRTVECEGS.....KASCVLKVDKP.SssC.ERR......PoSPu.RCtRh.......ssPu.....pQVPFMRTsMLpshFAsNR.NV.uSRlL.p	0	0	0	0
+3951	PF04599	Pox_G5		Poxvirus G5 protein	Mifsud W	anon	Pfam-B_5216 (release 7.5)	Family	This protein has been predicted to be related to the FEN-1 endonuclease [1].	20.10	20.10	45.60	45.30	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.60	0.70	-5.78	11	78	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	70	4	413.50	57	96.90	CHANGED	MGIKNLKoLLLcptsLppl...csh.+s.hstIFVDTMSlFholAasVssl--LpspFhcalpta.ppsG+VTLFlDRGsIsIKcsLREKR.+suhcNThKRKphElcp.........LpstIstLslsDhhYEEhKT-lcL+IcKLpFa.FLuspsNlKhs.L-csLstl...-sVsIlYCDslDAEFVMCpcAKcls.poGpWPllISoDQDTLLhuSsDshsKI..ItohsphYpalPssco+YLoKLlsLsNGCDaFsGLYGhsITpKoLpp..IpL....F-DFol-Nll+....SLshKNYsp.......Ktos+hlD.....lDpIIcFIscY.................osLDcslY.pppsssslolQEFlFoALsp+Wpphcsohlc.ssulhssLhslLc..P++cIsps-lpplpphlpcs.hp++sslssIpolssIFGYchspsssllhGIhshpslhLsacc...pFYFNspsIIc	...MGIKNLKSLLLEs+SLTlL...D-slh+laNGIFVDTMSIYIAVApCVpNLEELsolFlKYVNuWl..K..KuGHVTLFIDRGSI+IKQsVRDKR.RKhSK.TpcRKhLELEK..............................................................ssu-Ip..NV.ouhMtEEIKAEhQLKIDKLoFQIYLSDuDNIKho.LNElLT+h.psENVTlaYCDchDAEFVMCLEAKspapoTGEWPLIISTDQDTMLFuSsDsHPKh..IKslTQLFKFlPoAEssYLuKLTALVNGCDFFPGLYGtSITssNLNK..IQL....FoDFTIDNIVs....SLA...IKNYaR............K.TNosVD.....VcNIVTFINcY.................ANLDD.VY.ualP..PCQCTVQEFIFSALcEKWNcF.....KsSYLc.sVPLsCpLhYALE..PRKEIcVSEVKTLuohIDh-..NsKscI-sIKSIoSIFGYuscN..ss..oI.VFGI.hK.cNLLLulNs...oFYFNsollI.o................	0	0	0	0
+3952	PF04787	Pox_H7		Late protein H7	Waterfield DI, Finn RD	anon	Pfam-B_6266 (release 7.5)	Family	Family of poxvirus late H7 proteins.	22.10	22.10	22.40	29.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.76	0.71	-4.40	9	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	53	0	142.60	56	98.71	CHANGED	MDc+L+oluhThFpGELoThDIhsLthalhsppPp-TlFShc.csspFhIDFcY.DssLASsYlspphpsI.s-cYhsaushIAcELTNh-IIp-DlssYIpsSc+LKRhIKhY+s...pKps++IppssK+LKlAhp+GlDY-YIK-sh	...........MDKRhKSLAMTuFaGELsTLDIMALIMpIFK+HPNNTIFSVD.+.DGpFhIDFEY.DsYKA........SpYLDlsLTPIouDECKoHASSIAcpLsssDIIKEDIu-YIKToP+LKRFIKKYR....NRScsRIScDocKLKIALuKGIDYEYIKDAC........	1	0	0	0
+3953	PF03289	Pox_I1		Poxvirus protein I1	Mifsud W	anon	Pfam-B_4306 (release 6.5)	Family	\N	25.00	25.00	184.70	184.50	19.20	17.70	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.12	0.70	-5.59	11	65	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	42	0	0	54	0	307.60	73	99.43	CHANGED	MEp..-QLVLNSISA+ALKuYhsoKIs-hVDELVs+KasQKKKSpsK+hEsRIPlDLI+psFV++FpLcsY+sGlLsSLIsSLVENNYFop.DGKLs-sucpELVLsDlEK+ILupIs+sSsLYIDluDVKsLAuRLKssAssFpFssppYhLEsDKlE-lINpLs+NssIhLDEKsSlKDShYhls-ELL-VLKsRLFRCPQVKDNhISRTRLYDYFsRlTKp-EsKIYVILKDt+IAcILGIETVplGsFlYTKHShLlsoISuplDRYSK+Fp-sFYpsIAEaV..KDNEKlNVSKVVEsLhVPslph-t...E	.s.EhEDQLVFNSISARALKAYFTAKINEMVDELVTRKCPQKKKSQAKKPElRIPVDLVKSSFVKKFGLsNY.GGILISLINSLVENNFFTK.DGKLDDTGKKELVLTDVEKRILNsIDKSSPLYIDISDVKVLAARLKRSATpFsFNGHTY+LENDKIEDLINQLVKDEuIQLDEKSSIKDSMYVIPDELIDVLKTRLFRSPQVKDNIISRTRLYDYFTRVTKRDESSIYVILKDPRIAsILSLETVKhGAFhYTKHSMLTNAISS+VDRYSKKFQESFYEDIAEFV..KENERVNVSRVVECLTVPNITIuSNs.E..	0	0	0	0
+3954	PF04661	Pox_I3		Poxvirus I3 ssDNA-binding protein	Mifsud W	anon	Pfam-B_5571 (release 7.5)	Family	\N	18.60	18.60	18.80	18.90	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.80	0.70	-5.60	11	69	2009-09-14 12:26:09	2003-04-07 12:59:11	7	1	43	0	0	57	0	259.30	58	95.83	CHANGED	ssphppssscsst.hTCssslEasKSLSpSspKsIEuVpLosSQYPSCSsIsIsLs-oLuSKhsSsaIhlEGEuKIY+NKKsstpu......-sYFLKI+PouASPhLYQLLEsIYsNI+csp+lPsSLssl.slssh-EKTFpcGslYI..NKhsGAllEYpssG.sputlpolscElEsLuKRDtQhuKsIlsPIVFYRsuspsKVTFALKKlIh-R-hossVlDlsGcsp+lsMu.....Eo....sEE-hsRGLGll-..pD.........csh-E--t-..poLFNV	......................ts.p.csssuuDSlpTCuGVIEYAKSISKSNs..KCIEhVTLsuSQ.YssCSSISI+LT-SL.SSpMTSTFIhLEGEoKlYKNKucpsRS......DGYFLKI.KlTAASPMLYQLLEuVYGNIKcpcRIPsSL+uL.sVETIsEKTFKDEs.IFI..NKLNGAhVEYlSsG.ppSIlRSI-sELEuLSKR-+QlAKAIIsPlVFYRSGsETKITFALKKLII-REssANVIGLsG-SERVSMT.....Es....sEEDluRsLGlVDl.-D.........EhcEDsDcE..cslFNV.......................	2	0	0	0
+3955	PF04713	Pox_I5		Poxvirus protein I5	Mifsud W	anon	Pfam-B_5901 (release 7.5)	Family	\N	25.00	25.00	73.10	72.90	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.36	0.72	-4.27	11	51	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	32	0	76.80	53	97.05	CHANGED	hlss+ElhosIGlTlLhllMlloGuALlhKplsP.a+hlshRShshsRVlshLEalulllFIPGTlsLYuAYl+pLhh	...MhsAhslLoAIGITlLMLLMVISGuAhIlKclsP.pclhoMpSlpFNRsVTIhcYlulhIaIPGTIILYusYlKoLh...	0	0	0	0
+3956	PF04595	Pox_I6		Poxvirus I6-like family	Mifsud W	anon	Pfam-B_5073 (release 7.5) & Pfam-B_6224 (release 8.0)	Family	This family includes I6 proteins as well as the related F5L proteins.	20.80	20.80	37.30	34.40	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.89	0.70	-5.68	13	110	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	43	0	0	95	0	309.40	41	87.11	CHANGED	+pss..............ISFsFss.FYYsN-sLFsKPpNoL-DVsKSlllhpoFcYEpaVIpull+hL..+thualhDlaFlPlGWLsG....t--s....sspHlsl+...llh.oss..htsl+spl+-hLuhaslhshsl...hps-pclsIspFshsts....hPssVl.......ShaPFDs-t.lLlVlFFGpapDuYCGIoY.sss+-pl.tllphLtPhVuElplloD-lsRFsol+lhss..pss+tFPcsp.......ltoICEll+tF-cpcFsssssss.s....shssalPK+lVSllDLPSsV-I+CtScsGlDalTHIssK+LsslLlIsKDsFl+ssohsGTFKKENllW+GpYTYR......Ihc	................s...hIpaslDs.hahCscslho+.spT...h.cpllhhto.shpphhIpuhIKhl........hslhhlslu.Lp.....h-Ds....s.oHlh.t...lIh.soh...ISlKuplI-hhs.hshhshsh...hpschchpIsoFslssS....hPhphI.......pahPFsTD.....hhahG.hpc.hsG.sY................Ph.S.h..lSsphsRho.l+.hNs..hSshhFspNh.......lpsICE...pa-ths.sss..po.o......sups.lspclsShhs.....plps.scsssDa.T.hNscpLhhIllI.........Th.uhhlh..llhtuIhhY+............	1	0	0	0
+3958	PF03338	Pox_J1		Poxvirus J1 protein	Mifsud W	anon	Pfam-B_3556 (release 6.5)	Family	\N	20.70	20.70	21.70	76.40	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.79	0.71	-4.51	12	67	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	48	0	0	46	0	143.40	63	94.92	CHANGED	MDH.ppYLLThFLp-D-SFF+YluppsD-pAhuDlpsIsphLDFLLulLIRSK-KLEulGahYEPLSEp.a+slh-Fp.Dh+sL+pLFs+hsl.phs.spplpls+GYluDFVlSlhRLp+phths.ss..psspYIDPpcshthsNlluILp	MDH.sQYLLTMFFsDDDSFFKYLAuQDDEouLSDIhpITpYLDFLLhLLIpSKsKLEAVGHCYESLSEE.YRpLs+FT.D.p-FK+LFNKlPI..Vo.DuRV+LNKGYLhDFVISLMRhKKEsuLs.ossh-PlRYIDPR+DIuFuNlhsIL+.	1	0	0	0
+3959	PF03339	Pox_L3_FP4		Poxvirus L3/FP4 protein	Mifsud W	anon	Pfam-B_3380 (release 6.5)	Family	\N	25.00	25.00	30.90	156.20	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.95	0.70	-5.97	5	71	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	43	0	0	64	0	314.20	61	90.71	CHANGED	MptNNtsp-sscspspsplPps.s.ppsppshh....-..cFlEpRLCsYE+Eps.hph-ChluhhaslpKQVscE.......EssCWlELSuLV+u+KALGFPLlYusKcaoa.G+sLYFEpFKs...s+Vp+LTsso+ClsDsllFQIVlILYSLYK+sIaSD-FlFDLVSIPRSTIohSVNQLVFslsTDsLVVLSls.TRLY+AcLPQSCYLsYlau+ssLA.++shEooNY.FFEWFI+NHlchLo+QslDIFKlKK+YlTsspIsRLsEPGTLVYVh+-DhalhGITLT-VSloDNVRVLFSsDGt..slLEIDDFSlcDVFsAGELlsRSQsooI	..................t.+hNsppRh.p.s.hsps+sc.pss.ss.+pcNK..CR-......EsuDFINIRLCAYEKEYC...NDGYLSsA.YYMLKQVDDE.......EhSCWuELSSLVRSRKAVGFPLLKuAKRI.S+....G.S.MLYFEQFKN....oKVV+LTP.QlK..CLsDoVIFQsVVILYSMYKRsIYS.NEFCFDLVSIPRTNIVFSVNQLMFNICTDlLVVLSICGNRLYRTNLPQSCYLNFIHuH.ETIA.RRGY...E+SNY.FFEWLIKNHlSLLTKQshDI.hKVKKKYATGAPVNRLLEPGTLVYVP.KEDhYalGISLTDVSISDNVRVLFSTDG...hVLEIEDFNI+clFMAGEhFVRSQSSTI...	0	0	0	0
+3960	PF00485	PRK		Phosphoribulokinase / Uridine kinase family	Finn RD	anon	Prosite	Domain	In Arabidopsis the region carries two binding domains, a phosphoribosylpyrophosphate-binding domain and, at the very C-terminus, a uracil-binding domain.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.17	0.71	-4.75	12	8151	2012-10-05 12:31:08	2003-04-07 12:59:11	13	32	4282	57	1728	5333	1269	168.80	27	60.59	CHANGED	lIulsGsSGuGpoost+phsplFst..l.sh...............hsuhhphsps..chpht-cpsttspphoahuPcANsFDLhhphh+shtputsscp.hYsHsssptss...........pph.tssclLhhEGLHuhhspc...ltpLhDhplhlsss.slchhpKlpRDhspRG+ohEulhsoI..tRhPDassYIsPQhppsDlshpplPsstsu	...........................................................................................lIul.uGusuuG.....KoT.hu....ptlhp.h...lt.t.......ht...................................h..l.spD...s..a..h..h...s..t..p..h..h.......p.....c...t...h........h...t.....t.....t...h....s...h.......t.......t...P.....p......uh....Dh....p........h...L..h....p.h...l....p...p....l....t......p.........G.........p.......s....l....p..h..........P...h...Y....s.....ah....h.....t...s.hh..............................tp.....h...h..p..s.....s..c...l..l.IlE...G....l......h.......s...h.......t...s...tt..........................l..p.c...h.h.D...h...pl.....a.............V.............D.............s.............s...........................-..............l.............p.............h.............h.p+..............l........RD.h.........R.s.......h...s..h...p....tl...h..tp..........h...hhh.....a.t..a..l.tP..p..hphscl.h.........h.............................................................................................................................	0	527	1013	1414
+3961	PF04872	Pox_L5		Poxvirus L5 protein family	Kerrison ND	anon	Pfam-B_6088 (release 7.6)	Family	This family includes variola (smallpox) and vaccinia virus L5 proteins. However, not all  proteins in this family are called L5.  L5 is thought to contain a  metal-binding region [1].	21.90	21.90	22.10	22.70	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.66	0.72	-4.34	12	65	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	0	0	46	0	76.90	55	61.63	CHANGED	ElhhhFp.+s+hs.sPI-ph.pco.LhCctstLhI.sLP..ssphsALulstpPIshpsCcsLLpSING.SppVSLsDlLpR	.............ELsMhFh.Kp+lP.DP.ID+l.c+usLuC--DKLMIhGLP.hsspssALSIN.u+PIVYKcCscLL+SING.SQ.VSLNDlLRR...	0	0	0	0
+3962	PF03356	Pox_LP_H2		Viral late protein H2	Finn RD	anon	Pfam-B_3929 (release 6.5)	Family	All Members of this family show similarity to the vaccinia virus late protein H2. This protein is often referred to by its gene name of H2R. Members from this family all belong to the viral taxon Poxviridae.	21.40	21.40	21.40	76.20	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.95	0.71	-4.61	12	119	2009-11-17 14:52:54	2003-04-07 12:59:11	10	1	51	0	0	56	0	179.90	64	97.56	CHANGED	MDcTTLsVNGlEL-YsRp+tscslphA+sSTlhFFlllLhlSslLhaaQsScNslhsELs+YtRIKsslpuW+PLVpuKT+lES-RGRhhuhs.+sDhFpFpClDFGsYalPlRLDppTFLPQAIRRGpGDGWMl+KAuchDsSAQQFCEYllts+usNsITCGhcMhsclGYSGYF.suHWCushhsll	.MDKTTLoVNuspLEYlREKtscGIRuAKsSTlhFFVLILAlSuLLLWFQsSDNSlFuELsKYsRIKNsVpuW+PLV-SKTKLESD+GRLhAAG.+D-lFpFpCVDFGuYalPlRLDpsTFLPQAIRRGsGDGWMVKKAsKVDPSAQQFC-YLI+s+ScNVITCGscMhspLGYSGYFhssHWCSsh.sh....	2	0	0	0
+3963	PF04887	Pox_M2		Poxvirus M2 protein	Kerrison ND	anon	Pfam-B_6168 (release 7.6)	Family	This family includes M2 protein from variola virus.  The function of this protein is not known.	25.00	25.00	64.90	64.60	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.38	0.71	-5.00	4	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	26	0	0	40	0	194.80	75	88.90	CHANGED	pCsopcYRYW.LAupLTIGLsYsI.Ep..tEC+hc....s+hushllTGYGLpIshpITs.lspphVAuuEGhsssNpLslLLFhspchoc.tssl....plTITCh-h-CDssshcpsLssplpKN...-lhIhGSClTCVsL-T.Pspl......Nshhs+PhShhltcssuYohR.....sapcchspC.lDhccluYslC.+p	.........CPPRQDYRYWYFAAELTIGVNYDINSTIIGECHMSESYIDRNANIVLTGYGLEINMTIMD.TDQRFVAAAEGVGKDNKLSVhLFTTQRLDK...VHHNI....SVTITCMEMNCGTTKYc.SDLPESI.H+pSSCDITINGSCVTCVNLETDPTKI......NPHYLH.PKDKYLYHNScYuMRGSYGVTFIDELN...QCLLDIKELSYDICYRE......	0	0	0	0
+3964	PF03341	Pox_mRNA-cap		Poxvirus mRNA capping enzyme, small subunit	Mifsud W	anon	Pfam-B_3728 (release 6.5)	Family	The small subunit of the poxvirus mRNA capping enzyme has been found to have a structure which suggests that it started life as an RNA cap 2-prime O-methyltransferase. It has subsequently evolved to a catalytically inactive form that has been retained in order to help stabilise the large subunit, D1, and to enhance its methyltransferase activity through an allosteric mechanism [2].	25.00	25.00	45.50	45.40	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.72	0.70	-5.36	9	57	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	42	4	0	43	0	279.60	73	99.50	CHANGED	h-pltc.I+-GltshhPFY-oLP-LsLshGKs.LPSLEYGANYFLQLS+VNDLNRhsTDhLSLaTHDLhhsEoDLEKVYE.hsIcSVKoYGKoI+ADAVVsDLSA+NKLFKKERshlKSNNaLsENNLYluDYcMlTFEVFRPLF-huoEKaCIlKLPTLFGRsllsslRVYCSLFKsVRLaKssuDSWLKDSAIMVspcsaptNlscFhoalRcsTKSssW+DuNN.VpFslLcssV-+EFI-KFLsFSspVYEuLYYVHSLLYsSMTSEsKSIENEaQ+KLlKLLh	..MDcIsKNIREGsHVLLPFYEoLPELNLoLGKSPLPSLEYGANYFLQlSRVNDLNRMPTDMLpLFTHDlMlPEoDL-KVYEILpIsSVK.YGRShKADAVVADLSARNKLFK+ER-AIKSNNaLTENNLYISDYKMLTF-VFRPLFDhssEKYCIIKLPTLFGRsVIDThRlYCSLFKsVRLhKCVSDSWLKDSAIMVAS-lpKKNlDhFMSHV+SVTKSuuWKDsNs.VQFSILp-PVDoEFIsKFL-FSsRVYEALYYVHSLLYSSMTS-SKSIENcaQR+LlKLLL..	0	0	0	0
+3966	PF03213	Pox_P35		Poxvirus P35 protein	Mifsud W	anon	Pfam-B_2785 (release 6.5)	Family	\N	19.20	19.20	19.20	20.10	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.03	0.70	-5.43	12	130	2012-10-03 05:28:31	2003-04-07 12:59:11	9	3	65	0	1	104	12	279.60	48	99.48	CHANGED	MAtsp.....clslYVIPll.GRssp-VlPphct...h..tchcslKc..........ss...psp.thphs............+hh.Wp......Gsl-s...ac-.......YFSuhCphhCopEhKpolA+HhSLW-ph...spsshpss-scallVlEDDNTlpc...lp..sl+shIpuMp-psIDlLQLREshpssssRs.hs.t.tp.shasYsGGYDhSLSAYIIRluoAh+lhspIhcptGlSsuLshElh+lEpcLtlNR.VLssuspYVpH-h+hlsc+Rss.ch+sulhsRlusWluppaPshhYhlopPLFSFFGlFDIsllGllhlLaIllLlIFslNSKLLWFLuGhhhoYll	...............................................chslhVlPll.sRssu-shPpl+p...h....pc.hcslKc.......hsp.tsh.h.pscsch.hsh.................................thl.Wpt.....Gslcs...asc.......aFSuhCsshCTcEsKpsIA+HhuLWcSh...h.s-hcspcscalVllEsDNslcc.....lphlcsllpsMp-ppIDIhQhREhhpssp.s+s.h.s.p.ts.thasYs.GGYDhSLSAYIIRlssshplhscIIKstGlSouh.hElh+lEpchplNR.llssus+YV.H-.+hlscpRhp.ph+sshWsRluphhu+paPshhYhhopPLlSFFGlFDIsllGlllILFIlhMl..IFslsS.KLLWFLsGhhhThhl..................................................................................	1	0	1	1
+3967	PF03395	Pox_P4A		Poxvirus P4A protein	Mifsud W	anon	Pfam-B_2985 (release 6.6)	Family	\N	25.00	25.00	49.40	49.30	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	888	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.75	0.70	-13.56	0.70	-7.01	4	92	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	46	0	0	84	0	847.60	67	98.38	CHANGED	QLEcSEYlF+llSTlLPplC...............LDYKV--tLppTFVHPFDslh.sshGsls+t-plpsulppLGINYLlsshsp..+LFshllssspIthhssshths......................................................................................................................................................................s+sNPllNsHoFs-LPsFTpcLlphRhps.Et+ARFhGGYlhsctus....................ssshs.h....cYPsLsF-NTYhhNlLYpssIss.ht..F+..................................................................................................................................A+sssGlhhhpDasNLlulRsLlospspsRF-psashpphApcaslsls.s.s.sclDLhoMso........................................................................................KphlhahQaFsDpYtch.hpaNGsslh.sc.clhslslSh+YQuhIs+Lspha.slPlhNshslhshstspsttphslsh.slpalslssNlsaFlshhN.......hlA+EpRs..ssLcs.p.ShFWDGlDYp-YKpKplp-hhFIsuoCYVFuLap+NsTTaCShLoDhluAspTP.RVCllPRsluu.+TsscLluEsLcSlNshoh+-FP+pssStl.HIGLSEpGFMRFFQLLRLlss+s.EoAlKEVlhsYsGlKhuDpGsPah.I+p-SYpsFlhLLFuuMGF+VoV+pSlhGSsNhohIolRP.RVo+pYIsshLhKsSCS+s-A-KLlousa-LLsFMlSsush+DhpSYh.tRphssshaauG....s.ps--..tTIIphopPlslLDRlslpGlhuAsTlsEhLssDhFtPENthFKsNLpthIpSsploG..-sIhptMPhslLD+llTs.......AGssp.VSls-llDNIss.o.DCDtTN-IsDhINouLKcohsKcNshlsSpshsuVANpScppLtDl+pS.oC+hAslFKsLA+SIYTlERIFNs+lSD-VKh-hLEKhKsFosISpSLYsD.......LIulEslKAlLYIlKRSG+sl-cTpIssD...-l+KSYplI+PKIhshhNYYsphSRsYFppMKKNLNMpDsstsS	.....QLEDSEYLFRIVSTVLPHLC................LDYKVCDpLKTTFVHPFDlLLNNSLGSVTKQDEL.QAAISKLGINYLIDTTS.pELKLFNV.sLNAGNIDlINssINIS........................................................................................................................................................................SETNPIINTHSFYDLPPFTQaLLNIRLTDTEYRARFIGGYlKPDGSDo...................MDVLAEK....KYPDLNFDNTYLFNILYKDV.IsuP..I.cp.FK..............................................................................................................................................AKIVNGVLoRpDFDNLIGVRQYlTsp.DpsRFDssYsIsDAApHYGVNLN..TLPLPNVDLTTMPT.......................................................................................YKHLIMacQYFlss.........Y-+VsIYYNGN+hlasD.EIhsFsISMRYQSLIPRLV-.hFPDIsVNNNIVL+TRD.PQN.AsVNV.sV.sLPNhQ..FVDIs+NpKFFINFhN.........LLAKEQ.RS..TAIKV.sKSMFWDGhDYEEYKSKsLQDMMFINSTCYVFGL.YNHNNTTYCSILSDIISAEKTPIRVCLLPRVVGG.KTVTsLISETLKSISSMTIREFPRKDKS..IMHIGLSETGFMRFFQLLRLMADKPHETAIKEVVMAYVGIK.LGDKGSPYY.IRKESYQDFIYLLFASMGFKVTTRRSIMGSNNISIISIRP.RVTKQYIloTLMKoSCSKNEAEKLITSAFDLLNFMVSVSDFR...DYQSYR....Q....Y....R..........N..Y.......CPR...YF.YAGS...P.............................EGEETIICcSEPISILDRIDTRGIFSAaTINEMMDTDIFSPENKAFKNNLS+FIES.GD.ITG..EDIhCAMPYNILDRIITN........AGTCT.VSIGDM.LDNITsQS.D.CN.MTNEITDMINASLKNTISKDNNMLVSQALsSVAN+SKQp.IGDLRQS.SCKMALLFKNLATSIYTIERIFNAKVuDDVKAShLEKYKlFTDISMSLYKD.......LIAMENLKA...MLYIIRRSGC+IDDA.QITTD...DLVKSYSLIRPKILSMINYYNEMSRGYFEHMKKNLNMTDGDSl.......	0	0	0	0
+3968	PF03292	Pox_P4B		Poxvirus P4B major core protein	Mifsud W	anon	Pfam-B_4215 (release 6.5)	Family	\N	25.00	25.00	27.30	25.20	17.20	17.00	hmmbuild  -o /dev/null HMM SEED	666	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.24	0.70	-13.22	0.70	-6.58	9	314	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	152	0	0	187	3	273.70	52	97.52	CHANGED	MEoshs......lFlsu+lsLtssYsNphL.LlspsHlHtPspSlSCSlCsSLuplss.--hISAGARppR.sl+R...........R...stspsst....p.ss+psss.h........shVPIDEluSTpDWpl+LR+DGsAIA+YLpssKsDlpNFTIQDhlslM+KLNIhRosRsELFELLuHVKuoLosoSlSVKsTHPLVLIau+ucP+IG-QhKEL-+lYSsSpYphLLSTTRFQShHFsDMSSSuDLhFca+ssDSshFlHPIhhALFGlKLPALENsFVaGDSYSLLpQLach+KV+P-NYMLLVNRLTE-uPIlhTGVsDslSTEIQRAslHTMIRKhIhNlRMGIFYCp---ulDsaLMKIIHssCSplMoDEEQhLASILSIVGF+PsLVSVs+Puhussa....DMpLQoVPYIVVsPhKMITTSssPISINosslaSLTaDutoGRVlFsPsshuYtttsssssssshssh...sssshtpshsSPVIVNGsLlFYVERRQsKNhhuGECYTGaRSlIsDpPI-Vup-lslNGIMYRL+SAVCYKlGD...phh.ssCs.....uuDIFLKGaYTILFTEhGPWhYDPLSlasKuuR-uRLhRAhKNpYt+ps..sthD-up.FY-WlKG-Gus.hhtuKQQ.LMNHhsMF-DDLLoMEEAMSLISRpCCILIYAQDY-PYloAKsIo-lF	.................................................................................................................................................................................................................................................t.............shlsIDElTSTHDWQhpLRKDusAIs+YLh-pKCDlpNF.ThQDLlpVM+pLNIIRs-RpELFELLuHVKuoLossSV...SVKsoHPLhhIYu+scs+IG-QhK.L-shasPS.cYQsLlsTTRFQSspFsD..MSo.SS.DhLFcFK.cpD..Sh..halHPIlhA.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+3969	PF03296	Pox_polyA_pol		Poxvirus poly(A) polymerase nucleotidyltransferase domain	Mifsud W	anon	Pfam-B_4019 (release 6.5)	Domain	\N	19.50	19.50	19.90	19.50	19.30	18.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.85	0.71	-4.65	13	65	2012-10-02 22:47:23	2003-04-07 12:59:11	8	2	45	9	1	62	42	149.10	72	31.45	CHANGED	chsShcclAc...chLsShNVsshoc.cl..MGRHsVSsL....VssVNpLMEEYLRR....HNKsCICYGSYSLHLLNPcI+YGDIDILQTNuRsFLIsLAFLI+FITGpsVlLLKVPYLKNYhVL+DccssHIIDSFNIRQcTMpsIPKlLIDNIYIVDPs	.........N.lTSMEELARDMLNSMNVAlIDK..uKV..MGRHNVSSL....VKNVNKLMEEYLRR....HNKSCICYGSYSLYLIN..PNI+YGDIDILQTNSRTFLID..LAFLIKFITGsNIILSKIPYL+NYMVIKDENDNHIIDSFNIRQDTMNlVPKIaIDNIYIVDPT........	1	0	0	0
+3970	PF03294	Pox_Rap94		RNA polymerase-associated transcription specificity factor, Rap94	Mifsud W	anon	Pfam-B_4535 (release 6.5)	Family	\N	25.00	25.00	63.60	63.50	19.20	19.00	hmmbuild  -o /dev/null HMM SEED	795	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.67	0.70	-13.50	0.70	-6.59	10	107	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	53	0	0	84	0	595.20	68	99.97	CHANGED	M-oKESlLIEIIPKIKsYlh-sshssKSYsDFIScNKsIFllNLYNVusITEEDIRLLYsTIEQNhDlDDQTLlSIFSYIGYKFEQsl+EEIooSLthsEps.hTD-M.TaNhYsLFFNTLDMYlRQ+RINVLVND-ssuD......lsINY+..TSDLsSsF-sstEPEVREIPFNMK-hlsYVSKNlDQlRFSKKYLDFAYLCRHIGIPISK+KhNlRYlaLYclDGloIPIVI+DFLDVKYVYLcETGKsY+NsFSE-hNsSLhDWG+lIIPpL...KN++LYSYlFLSsYaL+DLF.-LIpp+-ssF+stcp.hctIpltEPtuW+c-VplEahPCEHQI+LtEAhKlDs-YFsKlNsFAsEYIYYEDGlAYC+ICGhNlPpFNlDAADVIKss..VIVoTaNKSIFLSEPYSYFVHSQRFIFNIIMSFDsIMKSQTWsMKYNINRLILNFLI-INu+RQcYEK+FusEI.K+GlFFLRLSANLFDIHsSSTELFYSuKhLNLNYIVlLVIlLNSSADFIlSYMsuKKKp........VsEooLKauISVIIYDFLlKT+ICEKsuLDTIs..LhT-VYhSIMPEELcsHapRIllEL+KLlSIpRocptPsYDV-s+h...Plssl..+FFsspslhsp.Mhshp.tch...pspslhpPs.hstsoc-shppF.cclThc--hKVLIRhNDTNAopLVhFsoHlKIEIE+KKlIIsLKs...................LFIsNsLKYYY..............SssuhYVFRFGDPFPFD--LIDppHVQaKlNsYNLLRaaLLPcSD.VFVYFucSLsR--LEYsFYhFLspYVNs.VppWIDENIo+IRELYhhNFNN	....M-oKEolLl-IIPKIKsYlhDsshssKSYsDFIupNKsIFllNLYNVssITE-DIRLLYhTIEQNhDssDpTLluIFSYIGYKFEpsl+E-hsoSL.hs-p..hTD-M.saNhYshFFsTLDhhlRQ++lslLVND-hp.GD......h.lsY+..sSDLsosFssph-Pcl+cIPFNMKshlsYlpKNlDQlRFSKKYLDFAYLCRHIGIPISK+KhNhRYlahYplDGloIPIlI+DFLDVKYVYLEpTsKhY+NsFuE-.Nsul.-WG+lIIPhl...Ks+tLYSYlFLSsaaLpshascLltpc-shFhthpp..hchItltEP.uWcccVplEhhPCEHQI+Lh-AhKlD.spYFsKlNsFspEaIYYEDGlAYCplCGhNlP.FNLDAuDVlKss..Vl.VsTaNKoIFLSEPYSYFlHSQRFIFNIIMSFDsIMKSQTWsMKYNINRLILNFLI-INS+RQcYEK+FusEI.K+GlFFLRLSANLF-.psSSTELFYsuKhLNLNYIVsLVIlLNSSADFIlSYMpSKpKp........VpEooLKYuISVlIY-FLlKT+IC-KusL-TIh..LhT-VYTSIMPEELclHapRIhlEL+KLlSIpRSthpPNYDVEspt.t...Phssl..+FFsspslhs+sM..ss...pph....hppp.IstPs..sp..octshppF.+c.lTsD-DlKlLIRhpD.TNAoKLVIFPoHLKIEIERKKlIIsLpo...................LalsNsLKYYY..............Sss.LYVFRFGDPhPF---LlDpEHVQaKINCYNlLRYcLLP-SD.VFVYFSsSLNRcsLEYuFYhFLupYVN..VppWIDENIo+I+ELYhINFNN......	0	0	0	0
+3971	PF03340	Pox_Rif		Poxvirus rifampicin resistance protein	Mifsud W	anon	Pfam-B_3377 (release 6.5)	Family	\N	25.40	25.40	27.90	86.10	19.80	25.30	hmmbuild  -o /dev/null HMM SEED	541	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.82	0.70	-6.44	11	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	11	0	61	2	518.40	71	98.91	CHANGED	hhsSlIss......--u...s+RpNVFusDsppPThYMP.QYIolsGlh...ssssssVls..aEIRDQYIsAhNpFlLoIsLPElKGlG+FuYlPYVGYKsIpcluls......SsNslIWEosGE-LFssshsscpA.phSGaSpELNDlSsGhoPNDsIK-ussVYlYl+TPFDs-..cTaSSLKL.u-oKlslslTFNPlSDlllhDusFsh-uF..l+-FVYssELSFlGYhV+slphKssYIEcs....RRsluQhNpsT..sslo-VaulTuLuVYlKP..aYG.h-N+FISYPGYsQTEccYIpuaV-RLL-DLlIVScs....hPcsF.P-su-lVEVPssGlVsIQ.DsDVhV+IDNVPsshslYaHTNlLlFGTR+NSssYNISKKFSsIsGsYScsTc+IhFoclpHolNIoDVSIPVulWsup+NlYsGDNRSspSKsKDlalNDPFlKGlDFhNK.hDlISRhEVRFGN-llYSEsuPIS+IaNpLLossssusRpL...........pFNasPtsFF+PTsLhANsSRGKDKLuVRVsapshDssNPIpYVsKQLVllCsDLY+loYDss.IplsKIs-	.................lINSLIGu......DDu...IKRuNVFuVDsQhPTLYMP.QYIoLoGVho....NsusDspslu.oFEIRDQYITALNHLVLSlELPEVKGhGRFGYVPYVGYKCIpHVSlS......SsNGlIWElpGEELYNsCl.NNshALcpSGYSpELNDIShGLTPNDTIKEsoTVYVYIKTPFDVE..cTFSSLKL.SDSKITVTVTFNPVSDIlIRDSoFDaEoF...sKEFV.YVsELSFIGYMV...KNlQlKPSFIE+P....RRVlGQINQsT..AslTEVHAsTSLSVYsKP..YYGNTDNKFISYPGYuQsE+DYIsAaVpRLL-DLVIVSDu........PPoGa.PESAEIVEVPpsGIV..SIQ.DsDVaVKIDNVP-sMSVYLHTNlLhFGTR.KNSFlYNISKKFSAITGTYS-ATKRhhFuHISHSINIhDsSIPVSLWTuQRNVYNGDNRSscSKAKDLFINDPFIKGIDFKNK.TDIISRLEVRFGNDVLYSENuPISRIYNELLopsssGTRTL...........pFNFTP+hFF+PTT.IsANVSRGKDKLSVRVVYSoMDsNpPIYYVpKQLVVVCNDLYKVSYDpG.VslTKIh.G......	0	0	0	0
+3972	PF03293	Pox_RNA_pol		Poxvirus DNA-directed RNA polymerase, 18 kD subunit	Mifsud W	anon	Pfam-B_4188 (release 6.5)	Family	\N	25.00	25.00	259.40	259.30	22.30	21.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.82	0.71	-4.73	10	55	2009-09-11 05:39:38	2003-04-07 12:59:11	9	1	41	0	0	36	0	160.00	73	97.25	CHANGED	MSTFsppVYLPVsLpPHELTLDl+cNI+cAVh+cYLHKEouGlMAKKI-IChDpELPLGEIVNNpVVV+VPClVTYKYYKlGDlVpGTLNIEDESNIoVtCGDLICKLsRDSGTVSFsDSKYCFIRNGpVY-NGSpVSVsLKEAQpGh.-SsFVFLAoIlD	MSoFVsNsYLPVTLcPHELTLDIKsNIRsAVYKsYLHREhoGhMAKKIEIpcDsELPLGEIVNNuVVIsVPCllTYtYY+VGDIVRGTLNIEDESNVTIQCGDLICKLSRDSGTVSFSDSKYCFhRNGsAYDNGSEVoAVLhEAQQGh.ESuFVFLAsIVD..	0	0	0	0
+3973	PF03396	Pox_RNA_pol_35		Poxvirus DNA-directed RNA polymerase, 35 kD subunit	Mifsud W	anon	Pfam-B_3921 (release 6.6)	Family	\N	25.00	25.00	92.40	92.30	19.60	18.40	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.80	0.70	-5.38	11	79	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	48	0	0	66	0	275.80	64	95.56	CHANGED	RcEpplsl-LsPulATFIKHGFNp+V+WPlLslGVVLsNTTTAVNEEWLTAlEahPTRKIFYsaspcILcpElsFCVYLpKo.QopscsYloLtDFDYYlIcsDs.php+l-KPKELcETLLHoFQEYR..hKNhQsIELlAFSSGTpIs--llppLo.FLslElFNREYsNlKsllsppFcohsPFIVlAPhG+LTFFlEcYsWhDhKoHlK-lLDaLEtsLluDl+SHplpss..hpD.s.ssSuYNssSGhLaVNDllTMslVNFFGCsuRLsoYH+FDhoplDscsFl+ALucAh	..REEsoIsV-L-PuLATFIKpGFNshV+WPLLNIGlVLoNToTAVNEEWLTAVEHlPThKIFYKHlaKILsREhGFhVYLK+S.QSEcDNYITLYDFDYYIIDpDs.olohVDKPsELKETLLHsFQEYR..lKSsQoIELIAFSSGTlIsEDIVs+LT.FLDlElFNREYNNVKsIlcs-FlupuPFIVIuPhGKLTFFlEsYSWhDFKSphKDIlDFLEGsLlAsIHsHhIcVu..ssD..ETVSSYNPpSGhLFVNDLhTMsIVNFFGCNSRL-SYHRFDMTKlDlEhFlKALS-Ah.	0	0	0	0
+3974	PF04490	Pox_T4_C		Poxvirus T4 protein, C terminus	Kerrison ND	anon	DOMO:DM04331;	Family	This family of poxvirus proteins are thought to be retained in the endoplasmic reticulum.  M-T4 of myxoma virus (Swiss:O55698) is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection [1].	25.00	25.00	49.20	49.10	24.80	18.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.99	0.71	-4.45	6	35	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	17	0	0	33	0	141.70	45	64.07	CHANGED	sppsFIlsslccuVYusGHhsYhEhSs.Nlshl-slPpCu+pIoluVSCDp.ssshp.atcppphpcs-lpIslphDoSCl+ahShshSlps.Cp++Louhup........-pLsCstlcsppHs+YLKoCssspFDR.haKpYh.HQ+salsKlhh	.pspsFIlssscpshaGssH.sYlEhSs.Nsus.-slPcCS+plplSV.CDQ.suslc.apchpphcssslpIslKhDoSCIcaluhshShhNECp++Looh.p........-pLoCsuhchps+sKYLKTCossKFDRpsaKpYh.+p+shhsKs..L....	0	0	0	0
+3975	PF04491	Pox_T4_N		Poxvirus T4 protein, N terminus	Kerrison ND	anon	DOMO:DM04331;	Family	This family of poxvirus proteins are thought to be secreted or retained in the endoplasmic reticulum if the protein also contains an additional C terminal region (Pfam:PF04490).  M-T4 of myxoma virus (Swiss:O55698) is thought to protect infected lymphocytes from apoptosis and modulate the inflammatory response to virus infection [1].	25.00	25.00	28.90	31.10	18.80	17.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.27	0.72	-4.13	5	44	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	24	0	0	36	0	46.50	59	24.35	CHANGED	TWclcIGLCIps.cDF+up+TGC..+hspGPGGLITEGNGFRIFsHD-C	.TWtLKIGLCIhA.KDFYscRTDCSVHhssuuGGLITEGNGFRllhHDpC..	0	0	0	0
+3976	PF03295	Pox_TAA1		Poxvirus trans-activator protein A1 C-terminal	Mifsud W	anon	Pfam-B_4259 (release 6.5)	Family	\N	20.70	20.70	21.10	93.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.95	0.72	-4.32	10	57	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	41	0	0	35	0	62.90	71	41.95	CHANGED	uMIKopVALREEPKloLLPLVhYccPEcVlslINsLRsKEGlYGoCaacEccpsIcloLRSLl	.SMVKSHVALREEPKISLLPLVFYED.EKVINsINhLR-KDGVYGSCYaKENuQhIcISLRSLL	0	0	0	0
+3977	PF03355	Pox_TAP		Viral Trans-Activator Protein 	Finn RD	anon	Pfam-B_3956 (release 6.5)	Family	These proteins function as a trans-activator of viral late  genes.	25.00	25.00	245.00	244.90	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.84	0.70	-5.02	5	56	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	42	0	0	35	0	253.90	80	99.79	CHANGED	MSLRIKIDKLRQIVTYFSEFSEEVSlNVDsuSslMYIFAoLGGSVNIWoIVPLsSNVFYDG-sNpVFNLPVLKVKuCLCSFHNDAVVoIEPDl-NssV+LSSaHlVSVDCNcEslPHRTsTuISLGIsQKKSYIFNF+KYEEKCCGRTVlHLDLLLGFIKCISQYQYLTVsFc.DKNLlLKTPGo+DTFVRcYSMTEWSP-LQsYSFKIAIsSLNKLRGFKKRVlVFEoKIVMDsDDNILGMLFRDRlGoY+VNVFMuFQD	MSlRIKIDKLRQIVAYFSEFSEEVSINVDSsDpLMYIFAALGGSVNIWAIlPLSASVFYcGs-NhVFNLPVSKVKSCLCSFHNDAII-IEPDLENNLVKLSSYHVVSVDCNKELMPIRTDToICLuIDQKKSYVFNFHKYEEKCCGRTVIHLEhLLGFIKCISQaQHLsIhFK.DDNIIhKTPGNpDsFSREYSMTECSQELQKFSFKIAISSLNKLRGFKKRVNVFETRIVMDsDDNILGMLFSDRlQSFKINIFMAF.D.	0	0	0	0
+3978	PF04441	Pox_VERT_large		Poxvirus early transcription factor (VETF), large subunit 	Finn RD	anon	Pfam-B_3920 (release 7.5)	Family	The poxvirus early transcription factor (VETF), in addition to  the viral RNA polymerase, is required for efficient transcription of early genes in vitro. VETF is a heterodimeric protein that binds  specifically to early gene promoters. The heterodimer is comprised of an 82 kDa (this family) subunit and a 70 kDa subunit. 	25.00	25.00	242.20	242.00	16.70	16.70	hmmbuild  -o /dev/null HMM SEED	700	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.39	0.70	-6.37	9	69	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	45	0	0	60	2	696.20	72	98.19	CHANGED	hYhVsPQLVlLVs+sQcIc+sLYLohYshID-p..SslY.YFl+saLch..ppPcll+RHILLTL+lpQlKGYlpsLLslp-DIIIYSHKNNLEYSYVDNTIFNPFs.TQ+KTLI+sD...uFLYNlYssACDFLVlWVApAs..DTslsEhGSY........EEVDsNILKFEp+LlpsFspLDL-holpSKFNNIFRTNL+.TGL+sIlpp.....p...sh+hLlh+oDEaFIshoGN+FlLsD.......EpLNLSIWDssssLAISSDGcTlhlNsVcLFT-lls-.slQMERIKu...DlTYKlaLsTPITS+lKLDIETSFIFlET.ATNNILLSsDKKISIILAKNHISIKVKNaIPNIEKYFTFLllulNphFNsVQpSuDFTKlETlYWSRICQNTKsKNRKPVIlsSLDss.MpKlSDNFY+Scp+....................EVFlNsNGlMFoChDPhG+YNslGFLuIFY+Lp+..hCIPCCFL+sQuHo-TFpSCVapc-.lpcshlsPYILNFGKlV.TpSKlSFLPIlFssahNcshpIshEpDNKRL+tTsGYaVV+uCpss....IhRlRThsDIIpFVNpsssILIssDhVYFPM....sh.chsN...+laILIQEIVHElVhl+KptcpDtIthh.ssps+...L+-hFPhposphsItp-sGlsLTTDGFalDGchFspcLSopassFhcNlospsts.uKYFu.lFKYVl.....T-sh-hFIKTWlINIMlphGhssp.st..hhstLEKYYsp	R.YIVSPQLVL.VGKGQElERALYLTPYDhIDEK..SPIY.YFL+SHLNI..ppPEIVKRHILLTLRMoQLKGYLGNLLDI+DDIIIYSHKNNLEYSYVDNTIFNPFVaTQKKTLlKsD...SFLYNVYPGACDFLVIWVARAs..DTSIPEFGSY........EDVDNNIlKFEThLhEVFPpLDLDhTVESKFNNIFRTNLKhTGLKKIIQ+Vp..-LDl.NYKSLLS+hDEaFINMTGNHFILND.......EpLNLSIWDhDGTLAlSSDGDTlMINNVKLFTDLV.SDIDTQMERIKG...DITYKVaLuTPIsSRIKLDIETSFIFIET.ATNNILLSoDKKISIILAKNHISIKVKNHIPNIEKYFTFLVIAINuMFNSVQKSuDFTKVETVYWSRICQNTKNKNRKPlIIs.LDss.MKKISNNFY+SDcK....................EVFINDNGIMFTCMDPLGKYNpVGFLNIFHchpK..hCIPCCFL+DQSHcsTFSSCVHQhD.V-KcIlSPYILNFGKVV.TESKhSFLPIIFDsFLNDGMoAshEQDNKRLKETSGYHlVRCCsG-....sIVRLRTsSDIIQFVNEDKNILIsNDMVYFPM....NsoDIGp...KIHILIQEIVHEVhIVKK+EooD+IDFFPPNYKL...LKDLFPKQThpssIpSDuGMsLTTDGFYIDGKLFN-DLSSKYVTFTKNVhsS..DuV.uKYFSPLFKYVI.....oEAKDRFIKTWhINIMl+MsVDPss....IIPsLEKYYPN.	0	0	0	0
+3979	PF04947	Pox_VLTF3		Poxvirus Late Transcription Factor VLTF3 like 	Finn RD, Iyer L	anon	Iyer L	Family	Members of this family are approximately 26 KDa, and are involved in trans-activator of late transcription [1].	25.00	25.00	35.80	35.50	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.96	0.71	-4.75	23	135	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	120	0	1	101	263	169.80	31	59.54	CHANGED	pthppssphs...hs+h.Ha+ssLpphQu+pssp........lsscllcplccclccpplp....................hsclspshVtpaLKcLs...h.sKpYcsshhIhphlTups...ssplspch-pplhchFcplhphapc..............tpcpshlsYsalLa+lhchh.....uhsppLssh.hlKstsKhpspD..placclhscLsWcahtt	........................p..pcsshas.s+h.Hh+psLc+h.u+p...........hss-llspLhchhcKppIs..................hs-lstshVpshLKthc...h..pKtYchVh.Ihsplpscc.....slosch.pclhclFcclhhhhpc.................ss.pphlsYSahL.Klh-lh.....uhscpLps..plKshsKtsspp..hlWcphhschphchh..p....	0	1	1	1
+3980	PF04498	Pox_VP8_L4R		Poxvirus nucleic acid binding protein VP8/L4R	Kerrison ND	anon	DOMO:DM04340;	Family	The 25 kDa product of Vaccinia virus gene L4R is also known as VP8.  VP8 is found in the cores of Vaccinia virions and is essential for the formation of transcriptionally competent viral particles.  It binds both single stranded and double stranded DNA and RNA with similar affinities.  Binding is thought to involve cooperative interactions between protein subunits. The protein is proteolytically cleaved during viral assembly at an Ala-Gly-Ala site. Possible roles for VP8 include packaging and maintaining the DNA genome in a transcribable configuration; binding ssDNA during transcription initiation; and cooperation with I8R protein to unwind early promoter regions.  VP8 may also function in either transcription elongation or release of mRNA molecules from viral particles [1].	25.00	25.00	26.10	174.20	20.80	19.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.34	0.70	-5.03	8	58	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	43	0	216.10	66	86.45	CHANGED	AKlKFPRShLSIaplVPRsMTRYELcLlpoEsITGsVFTTsYNl+KNLGls-.-KLThpsIEcYYLD.sN-VLTLMlsNTslscl..us.R++uRR.pKNPVlFRpGSsPLlllFcSRKKlsIY+Ecpcpss.sooYspIssslALls+YushpLLDVHoPSusLpLsAVYGh.sscpEL+KLuosKElEsYQsos.LpEPl+LsDFppLF-slKKsIsLTNlsh	AKsKFPRShLSIFNIVPRTMoKYELELlpsENITGAhFTThYNIRpNLGLGD.-KLTIEAIENYFLDPNNEVhsLlINNTDhouV...lPKKuGRR.NKN.VIFRQGSoPlLhIFEoRKKlNIYKENh-SA..sopYo.IGDNhALISKYAGlslLsVaSPSoSM+LNAlYGF.TsKNcLcKLSoNKELEsYSSoP.LQEPIRLNDFlGLh-CVKKNIPLTsIP.s	0	0	0	0
+3981	PF04395	Poxvirus_B22R		Poxvirus B22R protein	Mifsud W	anon	Pfam-B_3510 (release 7.3)	Family	This is highly conserved C-rich, central region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses. There are three pairs of conserved cysteine residues.	25.00	25.00	42.70	42.30	22.10	16.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.82	0.71	-11.44	0.71	-4.81	14	108	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	32	0	0	94	0	176.60	39	11.78	CHANGED	hssC-ssShphMspssulPcpFNsTLpphulpssssops..aYtC.hl.psss-C....uls.hhsssohpslsp..pppsppppRcpco....hpshpp-DhhChaptYshsppts-.......Csssp....................cppppccpscss.ssp.sclshhutccLGs..+shIPpcssclQlGspG.t-us....VsGDssIYppVKpchcptlpshhssss.....ssshPp	.............husCc.csSM..sLMsuVlssspEFNsTLcpl.G.lpsspssss...YYtC.hl.sssusC.phlsLsphlsshThssl.p...sshsssssR+pRs...................hp..ssc-lpClYcsYGlscp..sc.......C........................................hpps+ccp.scst.........pthcLhppupc-Lth..csVIP+uTT+hQVGupG.ssGs....VsGDss.apsVKschp.hhcchhPpls....hsh...cp........	0	0	0	0
+3982	PF00550	PP-binding	pp-binding; 	Phosphopantetheine attachment site	Bateman A	anon	SCOP	Domain	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-3.71	163	41592	2012-10-02 01:16:24	2003-04-07 12:59:11	20	3219	5404	127	13580	37590	2935	66.40	23	7.49	CHANGED	ptltp.hlsphl..t......t.ppl...sss.ssh....h.c.hGh.DSlthhplhsplpcp.h......h..plshs..plh.p.tsolpplsphl	........................................ltp.lhsclL.......s........h..ppl............shc..ssF..............h..-..LG...s..DSLtslclhs..p.l........c..cp..h..............u..l.........pl.ssp............plh...p...hs.....Tltslsth.........................................	0	3350	7619	11106
+3983	PF02503	PP_kinase		Polyphosphate kinase middle domain	Mian N, Bateman A	anon	Pfam-B_2701 (release 5.4)	Domain	Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.	25.00	25.00	27.60	26.70	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.22	0.70	-11.20	0.70	-4.82	173	3692	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	2906	6	697	2965	1012	200.80	31	31.95	CHANGED	pppppalcpaFpcplhPlLTPlulDsuHPF.PhlsNtoLslslpL..c..............s......s..................................................t........pt..h.AhlplP..psl.PRhl..pLP........ttts...................alhLEslIptalspLFsGh...clhssh.FRlTRsuDlpl-.p..--.sc.DLlptlcppL+.pR+hG..psVRLElsss.hspplhchLhc..........plplsc.p-lapl.sG..lsLspLhplss.hs...pscLcas.sasPt.hs..ttl	.............................................................................tpppalcpaFpcplhPllTPlul..D.s.s.HPF..PhlhsculslAVpl..p....p.........tps...................................................t..........................p.....tp..h.AllplP...psl..PRhlpLP.............................schs.t.th..........................alhL-sllpt..alccL...Fs..Gh...clhssapFRlTRsuDlpl-..p....--...s..c...sLhptlpppL.ppR+h.G..psVRLE....l.pps..........h.sp....t....h....h.c..hLhp..........chs.lsc.pDlahs.sG...lsLscLhplss.ls......+scLph..PasPhh....h....................	0	208	457	598
+3984	PF03012	PP_M1		Phosphoprotein	Griffiths-Jones SR	anon	Pfam-B_1336 (release 6.4)	Family	This family includes the M1 phosphoprotein non-structural RNA polymerase alpha subunit, which is thought to be a  component of the active polymerase, and may be involved in template binding.	20.60	20.60	21.50	21.50	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.94	0.70	-5.06	11	932	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	30	6	0	723	0	217.20	76	99.90	CHANGED	MSKIFVNPSAIRAGLADLEMAEETVDLVN+NlEDsQAHLQGEPI-VDuLPEDhp+LpIsDspssphsspssppEtup-EDFYhsEupDPhlPFQSaLDslGhQIVR+MKTGEtFFKIWSQusE-IlSYVssNF.PtPssKsoc-KSTQTssccsppssptosssp+-cpSspsshsup.-sSGPsuL-WusoN--D-uSlEAEIAHQIAESFSKKYKFPSRSSGIFLWNFEQLKMNLDDIV+pA+slPGVsRlAc-GsKLPLRCILGaVA.spSKRFQLLVsoDKLuKlMQDDLN+Yhup	.......................................HLQGEPIEVDsLPEDM+RLpLDDtKPSsLGEhA+sGEuKhcEDFQMDEGEDPuLLFQSYLDNVGVQIVRQMRSGERFLKIWSQTVEEIISYVsVNF.PssPG+SSEDKuTQTssRElKKET.hsuso.QR-SQsSKA+MsAQ.oASGPPALEWSATNEEDDLSVEAEIAHQIAESFSKKYKFPSRSSGIFLYNFEQLK.....................................................................	1	0	0	0
+3985	PF02818	PPAK		PPAK motif	Bateman A	anon	M Greaser	Motif	These motifs are found in the PEVK region of titin.	21.00	21.00	22.80	21.00	18.10	20.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.44	0.72	-4.04	33	559	2009-01-15 18:05:59	2003-04-07 12:59:11	10	58	28	0	180	495	0	27.60	59	1.68	CHANGED	PPsKVPEsPKKsVsEEKlslslPKK.Es	........PPAKVPEVPKKsVPEEKlslslPKKsEs...	0	15	15	26
+3986	PF01326	PPDK_N	PPDK_N_term; 	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	Finn RD, Bateman A	anon	Sarah Teichmann	Family	This enzyme catalyses the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP).	20.00	20.00	20.10	20.10	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.06	0.70	-5.40	101	5203	2009-01-15 18:05:59	2003-04-07 12:59:11	14	40	3545	11	1535	4567	2865	323.40	27	40.31	CHANGED	tsssth..h.GGKussLucht.............ptGl.sVPsGFslos.ss..apthh................st..l.t.l.th.t.....................ts.tthtthsttlpphlhp.sthP...spltpt...ltps..........hpp..hht.........................s.lAVR......SS.......................AssEDhsps..SFAGphcoh..Lslpu............cplhpul+psauShass+AhtYR........tpps.hst.............tpsthAVlVQpMltu........p..soGVhFTtsP..........hsu.ppst.hhlpushG.LGEslVuGps.ssDpahl..pp.th..........................stp.h.hh.........................................tttpt...sLs-...............................pp.....ltpLsph........upclEpt..aGt......P..D..IEWAlss.......sp...lalLQuRPloshtptsttt.tht.......................lpst	.................................................................................................................hp...th...l.GGKsAsLuEMh.................................................thGl.s...VP.s.G.FslTs.cu..hpp..ah....pp........................................................st.....l.p.p.l.hphhp....................................................l.ls..s..hs..th.t.t..s.hsthhp.hlls..hshs........sch...ps........ltpt..............hsp...hhs............................................sshs.lR..........oS.......................................................usuED..h.pt.........uh.AG.p.coh........lslps.......................................................h-pl..htAlctVauShhssRAlsYR..............htps..hsc..................................p.huhuVsVQp....MVhu.........................s....uoGVhFT.hss..........toG.tp..p..h......s.......h...hs.G..GE...sVV.s.Ghh...sP.cp...hh.h...t............................................................................................................................................tph......slps............................................................................................................................................................pt....hpcLs.chutplEpH....Y.tc........................s...DIEash-s............................Gc......LallQsRst...ppstttt.................p...................................................................................................................................	1	586	1082	1362
+3987	PF01239	PPTA		Protein prenyltransferase alpha subunit repeat	Finn RD, Bateman A	anon	Prosite	Repeat	Both farnesyltransferase (FT) and geranylgeranyltransferase 1 (GGT1) recognise a CaaX motif on their substrates where 'a' stands for preferably aliphatic residues, whereas GGT2 recognises a completely different motif. Important substrates for FT include, amongst others, many members of the Ras superfamily. GGT1 substrates include some of the other small GTPases and GGT2 substrates include the Rab family [2].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.44	0.73	-7.42	0.73	-4.39	143	2973	2009-09-11 15:11:22	2003-04-07 12:59:11	17	39	322	678	1957	2958	11	30.30	27	27.00	CHANGED	cELphspphlptsscN.assWpaRphllppht	..........pELphspphl..pp..sscN.a.ssWpaRphllpp...........	0	614	1031	1549
+3988	PF02541	Ppx-GppA		Ppx/GppA phosphatase family	Mian N, Bateman A	anon	COGs	Family	This family consists of the N-terminal region of exopolyphosphatase (Ppx) EC:3.6.1.11 and guanosine pentaphosphate phospho-hydrolase (GppA) EC:3.6.1.40.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.61	0.70	-5.22	10	5020	2012-10-02 23:34:14	2003-04-07 12:59:11	11	15	3248	19	1263	3783	1832	281.70	27	64.20	CHANGED	llschssGt....hphls+pKppV+Lu-u.hspss....hLsp-uhpRslssLpcFsElhpsass..pplpsVATuAlRcAhNu--Fls+lp+thG.....hsl-lIoGp-EARlsahGVspsh..scuctlVlDIGGGSTEllhGps.....tcsptlhSLslGsVplscpahscD..slspcphpth+chlcph..LpchssphchtG....htpslGsssThcsltplpssps.........ttpITtcclpphlcclhphsp.....cchcltGlsp-RAsllsuGslIlpulhctLphc.slplSssuLREGllhuhlhpc	.............................................................................t...stt......h.p.hl.s.ph.+p..hVRLupG...lspss...............tLsp-uhp.R.....u.hpsL.p.hFsch.h..p.....s.h..s.s......pp..l..p..sVA.Tu.slR..p..AtNu.s..-Flpcspc.hh.G.........h.sl.....cl.IoGpEEA+..Lh.a............h...G............l.......t.......p.....s.....h...............s.........p..........s..........c..............h........L.....V..l.D.....IGGGSTE..ll.hup.s.................................tp.stt....h...h...S.h..s..h.GsVp..h...t.....c.p...a.......h.....s.....s...s..............hs...p..c.p....h...p...t...h....pt........t...sppt..............l.p...s.....h...s....t.....p....h.ph.ts......................h.hs.l...G.....s...u..s.T....l.p.....s.....l...t.p.l...h...h..t..h.s.........................................sttlo.hpclpp....lhp...cl.h...p.hst...............hpc..h.p.l...G...l..s.t-R.tsl..lsuGhslltsl...hctl.....s...h.........p...p......h......tlu.ss.uLREGllhphh...h...........................................................................................................................................................................	0	378	804	1077
+3989	PF04403	PqiA		Paraquat-inducible protein A	Kerrison ND, Finn RD	anon	COG2995	Family	Paraquat is a superoxide radical-generating agent.  The promoter for the  pqiA gene is also inducible by other known superoxide generators [1]. This is predicted to be a family of integral membrane proteins, possibly  located in the inner membrane. This family is related to NADH dehydrogenase subunit 2 (Pfam:PF00361).	21.50	21.50	21.60	21.50	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.76	0.71	-4.66	167	3875	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	1245	0	618	2356	195	157.40	30	72.64	CHANGED	ulpcs.hAlhluullhhlsANhhPlhp..hph...hGt.ppssTlhuGlhtLh.ppGthslAhllhhsSlllPhh+llslhhLhhsh..pht...............h.t..htpth.lh+hlchlscWSMlDlFllullluLlclss........luslpsGsuh...hsFuhllllohhushphDsRhlWcthp.t.pp	.................................................lppshAhh.ls.ulllhl.ANl..hPlhh..........hpl.............hGs...p.psT..lhsGlh.L.h.pp...u...s...h.sl.As..llFlsolhlPhhpllslhh...Lhhss...c.ht.h...........................h.shppp......lhchl.ph.ltcWuMlD............l.F.............l.lulhluhl+..hts...................................hhs.ltsG.su.h...hhFshhllLThhus.phDsRhlW-ph....t.....................................................	0	132	279	449
+3990	PF01502	PRA-CH		Phosphoribosyl-AMP cyclohydrolase	Bateman A	anon	Pfam-B_782 (release 4.0)	Family	This enzyme catalyses the third step in the histidine biosynthetic pathway. It requires Zn ions for activity.	21.50	21.50	23.60	23.40	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.57	0.72	-4.35	168	3692	2009-01-15 18:05:59	2003-04-07 12:59:11	13	14	3587	2	1007	2642	1827	75.10	51	36.77	CHANGED	MlAaMNcEAlppTlpTGpspaaSRSR.pcLWpKGETSGphQpVp.clphDCDsDslLltVct......tGs..A.CHT......G.pcSCFap	............MluaMNpEALp+TlcoGc.ssaaSRSR.pcLWpKGETSGphQpVh.s......lphDCD.sDoLLlhVp...........hGs....s.CHT.......G.ppSCFh.t.............	0	326	664	868
+3991	PF01503	PRA-PH		Phosphoribosyl-ATP pyrophosphohydrolase	Bateman A	anon	Pfam-B_784 (release 4.0)	Family	This enzyme catalyses the second step in the histidine biosynthetic pathway.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.62	0.72	-3.70	53	4463	2012-10-01 21:36:44	2003-04-07 12:59:11	12	19	3909	57	1077	3829	3398	91.00	30	42.54	CHANGED	lpchccshttcttp.tPps..stphhsh........ptphlt.......EEh.sEhht.............Asp....ps.................................shsclsctlsDl.......lYhshGthsthG.......................l..c.hcslhcplccuN	.......................................................................h..phtphltp.Rpps....pPpsS...aTspLhscG...........pplspK.lG..............E..Eu...sEssl...............AAp.......st............................................................................................s.cp..c.lssEsuDL.......lY..Hh..h...V...hl.t..p.tG...........................................................................................l.....s.hpclhppLppp...................................................................	0	327	690	914
+3992	PF03208	PRA1		PRA1 family protein	Mifsud W, Bateman A	anon	Pfam-B_2976 (release 6.5) & Pfam-B_8147 (Release 8.0)	Family	This family includes the PRA1 (Prenylated rab acceptor) protein which is a Rab guanine dissociation inhibitor (GDI) displacement factor [2].  This family also includes the glutamate transporter EAAC1 interacting protein GTRAP3-18 [3].	21.30	21.30	22.10	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.99	0.71	-4.88	58	779	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	305	0	497	744	4	144.50	22	68.28	CHANGED	phptthus..hRPW.s-Fh.-hsphupP..pshu-htsRlppNLsYFpsNYhhlshhlhhhsLlh.pPhsLllh..hslhsuhhhlahhps................pslslhs+phsspphhh.................slhlsolh.llal..sus..ssslhhslshuhhllhhHAuhRt.sp.....h.ht-pcstths	.................................h...thsshRsh.s-Fh...s..........p....phuhP..pshschpsRltpNLtYapsN...Yhhlh.hhlhh..h.s.llh......pP........hhllsh..hhlhs..s...hhhlh..hhps.................pslhhh..t..p.phs.spt.hhh..................................slh.hsuhh...lhhh....su.s..hhslh.hslshshh.llhhHAuh+...p..................s........................................................	0	145	277	397
+3993	PF00697	PRAI		N-(5'phosphoribosyl)anthranilate (PRA) isomerase	Bateman A	anon	Pfam-B_247 (release 2.1)	Domain	\N	20.60	20.60	20.60	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.28	0.71	-4.76	23	3795	2012-10-03 05:58:16	2003-04-07 12:59:11	17	13	3604	9	968	2961	2133	193.90	32	66.13	CHANGED	s+hsulpphpDlhtshsssu....htuhlhssssp+phs.cpuptlhpsss.hh..lVGVFhNpslsplhphhpphuLDllQLHGsE..st-htphlt..lPll+ththstsht.....ht.sppt.p....shhLlD........utpGGoGpthDWshlpphht...........................hpllLAGGLsP-NVspAlp.......pshGlDVSSGVEos...Gl.KDhcKlptFlps	.................................................................................................................KlCGlop.p-spsAhpsGA.....shh.G.h..l..F...h.......p...S........R.............pV..........s.............h...c.p......A.......p...p............l...h...p...t.....h....s.....t......................hV.GVF..l..s........t...s...h......s.p.........l.h...c.....h..h.....p...p.h.s......L.shlQ.......L..H........G......s.......E..........s..t..ph.....h..........p.........t..........l....c...................t...........h....s........h.......h....p....s...lt..h...s..t..shp..................ht..h...p...p...h...tth...........DhhL.hDs............................................................sthGG.....oGpsF.D..Ws..l...l.ss.ht...h............................................................................................h.s.h.lLAG..GL...ss...-..N...ls..c..Alp.................hts....hulD..luSGVEss........Gh....KDhp+lpphhp.t........................................	0	323	632	826
+3994	PF03967	PRCH		Photosynthetic reaction centre, H-chain N-terminal region	Finn RD, Bateman A	anon	DOMO_DM03113	Family	The family corresponds the N-terminal cytoplasmic domain.	20.10	20.10	20.20	120.20	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.59	0.71	-4.58	21	85	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	78	111	27	89	105	137.20	45	53.31	CHANGED	Ms.sGshhuahDlAplslYsFW.lFFAuLlaYLppEs+REGYPLps-.ssustsspu......hhslPpPKTFcLtcG+.shslPsspp-....psclshsposshsGuPahPTGsP...hsDGVGPuuaA.RpDhP-lshcGps+IsPLRls	....M.tsshhuahDlAQlsLYsFW.lFFAGLlaYL+pEs+REGYPL-s-..ss....s....phtstG.....hhslPpPKTFhLsc.Gp.TholPsspss....ptsls..hptsushsGuPhhPTG.sP...MlDGVGPuuaAsRpDhP-Lsh.cGps+IVPLRl...	0	6	14	17
+3995	PF00432	Prenyltrans	prenyltrans; 	Prenyltransferase and squalene oxidase repeat	Bateman A, Finn RD	anon	Pfam-B_130 (release 1.0)	Repeat	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.07	0.72	-4.38	69	2497	2012-10-03 02:33:51	2003-04-07 12:59:11	16	40	482	411	1550	6750	154	43.70	26	14.26	CHANGED	hshcphhpalhppQp....-GGasspsss............pscsttohhulsuLslls	............................pplhpalhp.pQp.......sG.Ga.s.s.+.ssp.................................hsDs..ha..ohashsuLpll.............................	0	520	866	1268
+3996	PF01080	Presenilin		Presenilin	Finn RD, Bateman A	anon	Pfam-B_789 (release 3.0)	Family	Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease [2].  It has been found that presenilin-1 (Swiss:P49768) binds to beta-catenin in-vivo [4]. This family also contains SPE proteins from C.elegans.	24.50	24.50	24.50	24.70	24.00	24.40	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.44	0.70	-5.64	6	478	2012-10-02 13:41:03	2003-04-07 12:59:11	12	7	156	1	255	421	7	264.60	37	83.85	CHANGED	cEEtsLKYGApHVIhLFVPVoLCMllVVuTlpolpFYsppsu.pLlYTPFscpo.osup+hLsSlhNuLlhIuVlVlMThLLlVhYKa+hYKlIHuWLIlSSlhLLFlFohlYLpElh+sas.......lshshsTlhlhlhNFGslGMhsIHWKGPLRLQQhYLIhluALMALVFIKYLPEWTsWhlLssISlWDLVAVLsP+GPLRhLVETAQERNEslFPALIYSSs.hhhhVs........sss.t..posc.s..............................ssptps.........phsp.pps.ptpcDsusoptpp.....o...............ppsuhhhs....cphttph.-lps....s...p....pt..........pEERGlKLGLGDFIFYSVLlGKAuuo..GDWsTTIACFVAILIGLClTLlLLAla++ALPALPISIshGLIFYFuTchllpPFh-	................................................................................lh.PV.hs.Mh...h...s..h.h......h........................................................t..................................h.......h.h.............t...................t................th..t....uhhsshhhhshlhhhThhhlh.Lah.....hphhthlhsahhhushhll.hhh.sh.hh....lhptht.......hshD.h...oh.h..hhhhN.hu.slG.h.hs.l.a..h.t..s..sh...l....pQhYllhhuslhA..h.......hhphlP-...WosWhlLhhhulaDlhAVLsPhGPL+hLl-hAppRsc...PuLlYput......h....................................................................................................................................................................................................................................................................................................................................................................................................................................ttslKLGLGDFlFYSlLlu+....Au............sh.s.hhsshl.ullh.GLshTLhlLuh.h.p...c...sLPALPlSlhhuh.....hhhh.st.hh..................................................................................................................	0	93	133	193
+3997	PF03991	Prion_octapep	Prion_octopep;	Copper binding octapeptide repeat	Bateman A	anon	Bateman A	Repeat	This repeat is found at the amino terminus of prion proteins.  It has been shown to bind to copper.	12.10	0.50	13.10	0.50	11.80	0.40	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.22	0.75	-5.16	0.75	-2.73	5	127	2009-09-13 17:14:17	2003-04-07 12:59:11	7	9	13	0	5	130	0	7.80	94	27.84	CHANGED	PHGGGWGQ	..PHG.GGWGQ.	4	0	0	0
+3998	PF03063	Prismane		Prismane/CO dehydrogenase family	Griffiths-Jones SR, Bateman A	anon	Pfam-B_2956 (release 6.4)	Family	This family includes both hybrid-cluster proteins and the beta chain of carbon monoxide dehydrogenase. The hybrid-cluster proteins contain two Fe/S centres - a [4Fe-4S] cubane cluster, and a hybrid [4Fe-2S-2O] cluster.  The physiological role of this protein is as yet unknown, although a role in nitrate/nitrite respiration has been suggested [1]. The prismane protein from Escherichia coli was shown to contain hydroxylamine reductase activity (NH2OH + 2e + 2 H+ -> NH3 + H2O). This activity is rather low. Hydroxylamine reductase activity was also found in CO-dehydrogenase in which the active site Ni was replaced by Fe [2].  The CO dehydrogenase contains a Ni-3Fe-2S-3O centre.	21.70	21.70	28.20	24.40	20.20	19.50	hmmbuild  -o /dev/null --hand HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.80	0.70	-6.13	251	2395	2009-09-15 11:55:15	2003-04-07 12:59:11	15	14	1486	49	664	2022	69	468.60	34	95.85	CHANGED	MaChQCpps....ts.suC.phs.................GVCGKss-sushpDlL.lhshpGluthupc.u+ch..........tspphhhpuhFsT.....................lTNssFcspphlphlpcshsl+...pph...............................................pshpphstpss.........phhlsthtpp..sp..DlpuLcphlhaGlKGhs.........AYtcH............AhhL.Gtt-c-.lhphhpcshssh..ss.csls......tllshslcsGths.hpsMtlLDpussttaGsP....ps..TpVslGlh.ps..ssIlloGHDlpshc.LLcQTcspGlslYTH.....GEhLPupsYPsh+..pYpH.......hsGsaGsuWppQpp-FsuhsusllhToNClhPs..h.p.sp...Y+s+laTTuslua...PG.spHI...p.............tpt.....t......................cDaotlIcpAlcshs.p.............c.............ps.p......lhs......GFu+psllshu..............c.......................tll-A.....................................................VKsGsI++hhlluGCDGt+ssRs..Yas-hAcpL.PpDsllLTsGCuKa+a...s+hsLGsl.........G.G...................IPRlLDhGQCNDuYuhlhlAhtL..AcsF......s.s.-lN-LPl.....uhsluW..aEQKAVslLLsLLsLGl+sl+LGPohPuFlSPsVhplLs-s....a..slss..hs.slEpDhpthh	..............................................................................................MaChQCp........ssuCpht.................GhCGKss-sushQDhL.lhshp..G.lu.sas..hc...uRcht.............................scphh.puhatT..................lTNsNFcs.phlth..h.tp.t.hthcpth.....................................................................................................tshtph..tpst.......ph...h..t..ttt...tt..shhslc.hhhhsh+sh...........ahcp............uhh.....sthc...........p-lh.t.....hpp....hh.s.hh..ss....shs..........llthshchGths.hpsMtlLDtupTtt..a....GpP.............ps...opVslt....sh.ts..hsIlloGHDLpslttLLcQ...o...c...u....p......G....l....slYTH......GEMLPupsYPth+..+apH..................hsGshGsuWtpQph.FsthsusIlhToNClhss..s.......YpsRlaTpu.suh......PG.s.p.H.l...p...............................t....................cDFs.lIppAhph.s.......t...t...hhhshshs....................................................slhuhActll-h......................................................................VppGpl++hhlluGCDuhpst+p....Yas-hAppl.PpDslILThuCuKa+a...s+.hshGsl..............s.G...................lPRllDhGQCNDuhuhhhlAhtL..uchh.............s.h..slN-LPl....shsluW...aEQKAlslLLs..LLtLGlpsIhhGPshPsFhosslhtl.Ls-p.......a.....sltsls..ss-pDhpth..............................	0	274	478	585
+3999	PF00484	Pro_CA		Carbonic anhydrase	Finn RD, Bateman A	anon	Prosite & Pfam-B_9319 (Release 8.0)	Domain	This family includes carbonic anhydrases as well as a family of non-functional homologues related to YbcF.	22.10	22.10	22.10	23.40	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.89	0.71	-4.22	497	5590	2009-01-15 18:05:59	2003-04-07 12:59:11	14	20	3442	146	1635	4073	995	149.00	28	64.39	CHANGED	slhluCuDSRls..sphlh.shtsG-lFVlRNsGNlls................................stss.huul-a.......AlphLpV.ccIlVhG....HssCGulp......su..........h.............................shlsp....hl....pthpsshpp.......htt..tt......................pph..........ph.............ctNVhpplppLppp..Phlp....pthtpup..........lplpGhhYclps......Gpl	...................................................lhluCuDSRls.....sphlh..s......h......t......s......G..-.lF.Vl..RN..suNlV...........................................................stsshu....ul.pa.....................AVp.....h.L.p..V.c.......cIlVhG....HssCGulp.......us........................................hp.........................s.................hshlpp..a.l..pp.h.p.ss.hhp.........hpph.h.tt..........................................s.pph....th......hc.sVhppltpLtpp..shlp..................t.t.h.t.c.sp.............................ltl+GhhYslpsGp.................................................................	0	480	1010	1381
+4000	PF01619	Pro_dh		Proline dehydrogenase	Bateman A	anon	Pfam-B_1092 (release 4.1)	Family	\N	27.00	27.00	27.10	27.00	23.80	24.20	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.91	0.70	-5.44	15	3379	2012-10-01 19:29:00	2003-04-07 12:59:11	13	21	2877	20	991	2741	1035	291.10	31	35.23	CHANGED	lsG-sltpslcpscpLc....ppthphohDhLG.........Etspsss-Apphhhshtpslpslucpstst...........thhthPshph.phstLh.phs.....shpp-h...shpphlt+lcslsptApchslslplDAE-pphhpho......lclhtc..h.p.tppshsslGsslQAYL+csspslctlhslAp+pshh....htlRLVKGAYh-uEtp+Ap..Gh.s.ssaopcspoDhtap...shschlhtscsh......lastlAoHNscolAhshplscppt.hs...spaEFQpLaGMu-tlpppLspps......hssRhYsPaGsh...pchluYLlRRLhENsuNsuFsp+thshp	....................................................................................................................................Gpsltpshtthcthp....ppGhphoh.D...hLG...................................Essh.stt-.Apthh..tpa.....phlc...slspt.s....s.....................................s.....h....h......photlp..s....+.h..s.........phphct..........shpph.h...s...p.l...pp...l...s...th...A.........c..........p...h..........s...l.t.lsIDAE-tsc...L....-ho...........................lclhcc.....h..............p...........................h.......t........s.......a..........s...s.......l.G..hVlQAYh...+cs..slchLh.chApcp....tht.....lhlRLVKG.AYh-sEhth...up..........G..........h..t........h.ssaoc...Kht.o.Ds..sYh......................shh....c....h..l..L..t...s..sph.......................lasthATHNspol..uth....h.p......h....s..........t...p...p...............h....h............................................................s..p...............aE..F..QhLaG........Mu-s....lhc....p....l..ss..ps............................hss.RlYsPh...Gsh...cs...hluYLlRRLhENs.ANsuFsp+hhp..t........................................	0	297	600	836
+4001	PF00160	Pro_isomerase	pro_isomerase; 	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	Sonnhammer ELL, Wuster A	anon	Prosite	Domain	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation.  Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA).  Other roles for cyclophilins may include chaperone and cell signalling function [1].	20.80	20.80	20.80	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.41	0.71	-4.01	168	13237	2012-10-02 15:38:38	2003-04-07 12:59:11	16	154	4706	283	5300	10643	4524	159.30	35	60.14	CHANGED	hlph..ps...........G.plhlc....L.hsctu.PhsspNFl.p.........Lsp..................pG..........................aYc..sshFa......R.l..........lps...F........hl...........Q................uGc...........................................t......ss.............s........................h.sEh..........................................................................p............pt..GsluMA.pt.....................so....s.uSQFFI......sh..............................ts.........................s.......tL..D........s..........ta.slFGcVl..pG...h-.llcpIp.p........s.........................lhIhpstl	....................................................................................h...lpTs......hG.c.I.t.lc...L....a..s..c...t......u.Pp.Ts.c.........N....Fh..s...........L..sp..........................pG.................................................................aY.c....Gs.h.....FHR...V....................................Iss...........F...............................Ml................Q............................G.GD...............................................ss...sst.........................................hut............p....................hpsE.h............................................................................................................tlpp...........tt..GsL.u.MA..psG..........................Pso..................s.GSQ......FFI..sh........................................................................................s.s.......................................ss...........aL..D........s....................pa..sVFG.c....Vl..........cG..............h-...V..l.c..pIp.p..........................stsst.............stPhps..lhItpst...................................................................................................................................................................................	0	1874	3188	4422
+4002	PF00235	Profilin	profilin; 	Profilin	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.69	0.71	-4.00	72	1081	2012-10-02 21:07:43	2003-04-07 12:59:11	14	8	440	49	440	984	4	121.20	33	90.65	CHANGED	SWQuYVD.....ppLhus......Gp.lspAAIlG.p.D...G.u...........lWA...pSss...F.plps....................pEhssIhss.Fpp......s...sslhssGlpluGpKYhslp..u-.....sps..lh.uKKu.psG.....lslhKTspAllluhYs-s...................hpsGp.sspsVE....cLuDYL	..............................................................uWpsYlD......pL.hss..........up..lssAAIlG..pD.....G..s.........................VW..A.pSss.....F.phps.............................pElsslhss.Fs-........s......spltssG..lhluGp..........KYhllp.....u-.............sss....lh..u.....K.....K..u....suG...........lsltKT..s.pAll.lu.hYcEs...................hpsG.p.sshhlcplucYL...................................................................................	0	172	257	346
+4003	PF02161	Prog_receptor		Progesterone receptor	Mian N, Bateman A	anon	IPR000128	Family	\N	24.10	24.10	24.10	24.80	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-13.11	0.70	-5.68	5	113	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	60	0	25	104	0	382.60	60	62.18	CHANGED	MTElpuK-sRAPHsAGussSP..s.pP..tRpDussh.uSQsSD..........s.utsSulPlu.LDuLLFsRpsQup-.P-EKsQ-pQshsDVptA.sclEAocs+GusSsRP..PcpDsssLDSVLDTlLAPSGPuQupsS.PAhEstoSWCLFGPElPEDPRus.uopthloPLMSRPEuKAGDuuGhuuupKs.P+ulSPSRQ.L.PssGustWPGAsuKsusQsAsluVEE-uGhcAEGSsGPLLKGKPRsLuGsuuGGGAsAsAPGs.sGGhs.VPKEDSphuAP+sSLsEQDAPsAPGpSPLATTshDFIHVPILPLNsAaLAARTRQLLEuE.oYDGGA.....FAPPRSSPSAsssPVPuGDFPDCuYPP-u-PK-DuFPlYGDFQPPALKIKEEEEGsEAAuRSPRPYLuAGAuuAsFsDaP......PPhPPRAPsSRPGEuA...sAssususSssSSsGPoLECILYKAEGAPPsQGPFAsuPC+sPuAuuCLLPRDuhs......uAssSuAAPALYsPLGLNGLPQ.LGYQAAVLKEG.LPQVYPPYLNYLRPDSEASQSPQYSFESLPQ	.........................................MTELpAKssRssHsuGusPSP.pluSPL.sR.sss.F.uSQsSD..........s.s.sSulPIS..LDGLLFPR.CQGp-..stKTQspQsLuDV-GAa..stsEAspusG.....usuups..PEKDpsLLDSVLDTLLsPuGstQSpsS.P.A.sEshosWCLFGsELPEDP.us...PuTptlLsPLMSRstsKsGDuSthuAupKlhPpGLSPspQLL.PsssustWsGAssKPus.ssssp.sEE.-su.cs-t...ususlLKucPRs.tGssttuth.ssssu.hs.Guhs.sP+EDuRhsAs+suL.E.pDuPhAPGRSPLAToh..hDFhHVPILPLstAhLAAR..TRQLLEt-.sYDGGA.........FusPRuSPsAsSsslssuDFP-ssY.s.-s-sK-ssa....shau-FQ.PsLKIKEEptusps.........sYhsuustsss.h.ch..............s.ps...............................s.sssLEClLYKAEs..A.st.....ssass.Ps+ssusuuClLP.tp................s.ssuuu...sP....slY.sLuLNGh.Q.LGYQA.AVlK-u.LsQVYPPYLNYL..R.PDoEsSQSPQYuF-SLPQ...........	0	2	2	6
+4004	PF02244	Propep_M14		Carboxypeptidase activation peptide	Bateman A, Mian N	anon	Pfam-B_2335 (release 5.2)	Domain	Carboxypeptidases are found in abundance in pancreatic secretions.  The pro-segment moiety (activation peptide) accounts for up to a  quarter of the total length of the peptidase, and is responsible  for modulation of folding and activity of the pro-enzyme.	22.10	22.10	22.10	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.14	0.72	-4.31	103	1016	2009-01-15 18:05:59	2003-04-07 12:59:11	11	15	167	24	581	999	1	73.10	22	16.68	CHANGED	a+l...pspsppplplLppLp...ps.plcFWpsss....thspssclhVsspphtshpshLpppslpaplhlpslQphl-pEp	.........................hcl.spspppl.phLppLp...........pp.pl.cFWpsss.......t.sps.lDlhVss..p.ph...p.s.hpshLppp.sl.p.a.p..lhlc.slQphl-pp.........	0	141	201	408
+4005	PF04352	ProQ		ProQ/FINO family	Mifsud W, Moxon SJ, Bateman A	anon	COG3109 & Pfam-B_7673 (release 7.7)	Domain	This family includes ProQ, which is required for full activation of the osmoprotectant transporter, ProQ, in Escherichia coli. This family includes several bacterial fertility inhibition (FINO) proteins. The conjugative transfer of F-like plasmids is repressed by FinO, an RNA binding protein. FinO interacts with the F-plasmid encoded traJ mRNA and its antisense RNA, FinP, stabilising FinP against endonucleolytic degradation and facilitating sense-antisense RNA recognition [2].	21.70	21.70	21.80	22.00	21.00	21.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.39	0.71	-4.47	46	1580	2009-09-11 08:23:37	2003-04-07 12:59:11	8	2	1071	7	186	857	21	115.00	41	57.46	CHANGED	p+hsss.ppslshLtcpFPtsFstpst.hpPLKlGIapDLhtclpptt...lS+spLRpALppaTpuhRYLpuh.ptGssRlDLsGpssutlot-csp+ApppLtcp+p.csttcctppt..s	.............................phpsscEslshLtcpFPtsFss..-st...s+PLKlGIhpDLl-cl....ut..c........LS+spLRsAL+hYTp...ShRYLtul.KsGAsRhDL-G..pPs....Gclsppcsp..aAppp......Lpct+s...+sptpcttQ.ut........................................	0	25	76	133
+4006	PF02428	Prot_inhib_II		Potato type II proteinase inhibitor family	Bateman A	anon	Pfam-B_2913 (release 5.4)	Domain	Members of this family are proteinase inhibitors that contain eight cysteines that form four disulphide bridges. The structure of the proteinase-inhibitor complex is known [1].	20.40	20.40	20.90	20.40	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.21	0.72	-3.91	10	341	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	42	25	13	355	0	48.10	62	74.95	CHANGED	sKACTpECDPclAYuhCPRSEGs..h.sslCTNCCuGhKGCpYYusDGoFICEG	.......PKACP+NCDsRIAYulCPpSEpp..tps.pICTNCCAG...p..KGCpYFSsDGTFlCEG............	0	1	8	11
+4007	PF00260	Protamine_P1	protamine_P1; 	Protamine P1	Finn RD	anon	Prosite	Family	\N	20.50	20.50	20.70	20.60	17.20	17.60	hmmbuild  --amino -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.00	0.72	-4.15	14	147	2009-01-15 18:05:59	2003-04-07 12:59:11	15	1	133	0	9	97	0	47.40	74	96.52	CHANGED	ARY.RsCRSpSRSRC.RRRRRRs+...............RRRRRpsRRRR...Rt..ssRR...Ysh..RpRR	.ARYRCCRSpS..RSRC..RR...RRRCR.RRRRRCCRRRR.Rs..CCRR...YThhRCtR..	0	1	1	1
+4008	PF00841	Protamine_P2	protamine_P2; 	Sperm histone P2	Bateman A	anon	Pfam-B_1350 (release 2.1)	Family	This protein also known as protamine P2 can substitute for histones in the chromatin of sperm (Swiss). The alignment contains both the sequence of the mature P2 protein and its propeptide.	25.00	25.00	25.30	37.70	24.10	18.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.63	0.72	-3.43	4	60	2009-09-11 10:14:09	2003-04-07 12:59:11	14	1	43	0	8	54	0	92.80	65	88.38	CHANGED	MVRYRVRSPSEsPHps.tQphcspEQG....p-QGLSPEcVEsYGRTHpG+aHYR+RpCSRRRLhRlH+p.+RSCRRR+R+uCRHRR........R+RRGCRpR	.MVRYRhRSPSEpP..Hps.GQ.phctpEQG....ptQGLSPE+VEsY.GRTHRG+p.HaR+R+CSRRRL+RIHRR..+RSCR.RR.RR...RSCRHRR...........RHR..RGCRpp...........	0	1	1	1
+4009	PF03247	Prothymosin		Prothymosin/parathymosin family	Bateman A	anon	Pfam-B_3463 (release 6.5)	Family	Prothymosin alpha and parathymosin are two ubiquitous small acidic nuclear proteins that are thought to be involved in cell cycle progression, proliferation, and cell differentiation [1]. 	23.90	23.90	24.10	24.20	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.24	0.72	-11.24	0.72	-3.89	8	185	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	42	2	61	210	0	90.50	59	75.61	CHANGED	uDsuVD..uusElosKDLKEK.KElVEEsEsuK-....sPsNGst.sEENGppcuDsp.--EEEs..-E--EE--G-G---Es---E.......Es-GsTsKRAAE...-E-D-s-sKKQKTD-sD	............u-tsV-..susElosKDLKEK.KEl..VEEuENG..+-......APANGNs...NEENGEpEuDsEs-EEEEp......tE-p.....E......EE-s....-.GEEE-s-E-E.......E.sEusssKRAAE.......pE-D-lDsKKQK.T-ps................	0	3	8	21
+4010	PF05044	HPD	Prox1;	Homeo-prospero domain	Moxon SJ, Bateman A	anon	Pfam-B_5293 (release 7.7)	Domain	Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos.  It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain.  However, the structure shows that these two regions form a single stable structural domain as defined here [1].  This homeo-prospero domain binds to DNA.	25.00	25.00	42.70	42.70	22.60	21.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.94	0.71	-4.56	13	191	2009-09-11 05:20:22	2003-04-07 12:59:11	7	3	88	3	116	167	0	139.90	65	21.88	CHANGED	psLTPhHL+KAKLMFFYTRYPSSslLKsYFPDV+FN+ssTuQLlKWFSNFREFYYIQMEKaARQALuEGlsssc-lhVo+DSELa+sLNhHYN+sNchEVP-pFltVsppTLREFFsAIpuGKDs-PSWKKsIYKVIs+LDcpIPEhFKSPNaL-cLp	..................p.sLoPsHLKKAKLMFFaTRYPSSshLKsY...FsDVKFNRClTSQLIKWFSNFREFYYIQMEKaARQAls-GVos........s........c..-LslsRDsELaRuLNhHYNKuNDFE.....V.P.-pFlcVsphTL+EFFpAI.uGKDs-PSWKKsIYK...lIs+LDs.lPEhFKossh.....................................................	0	23	31	75
+4011	PF02840	Prp18		Prp18 domain	Bateman A	anon	Bateman A	Family	The splicing factor Prp18 is required for the second step of pre-mRNA splicing. The structure of a large fragment of the Saccharomyces cerevisiae Prp18 is known [1]. This fragment is fully active in yeast splicing in vitro and includes the sequences of Prp18 that have been evolutionarily conserved. The core structure consists of five alpha-helices that adopt a novel fold. The most highly conserved region of Prp18, a nearly invariant stretch of 19 aa, forms part of a loop between two alpha-helices and may interact with the U5 small nuclear ribonucleoprotein particles [1].	22.10	22.10	22.30	22.30	21.10	22.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.81	0.71	-4.38	29	352	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	294	2	249	327	2	137.60	42	40.45	CHANGED	l.............htalphl.....LpcWcppLpscppp....tpohpuc.s........hsthhQT+cpl+PLhcpl+p....p..pLspDILpsLspIlpthp.pRc.......YhcAsDuYlcLuIGNAsWPlGVTMVGIHpRo.....uRpKIau.sp....l..AHlhNDEpTRKYIQulKRLlTFsQphaPs.c	..............................................htahphlLppWtppLspcppt................+pohpGK.s.................sshhQocchl+PLF+pl+c.........p..sLssDIhpslsc.Il.ct.h..p.Rc.......YlcAsDuYLcluIGNAsW.....PIGVTMVG.IHtRo.....uREKIas...pp.....lAHlhsDEspRKYlQulKRLhThsQppaPsc.........................	1	85	132	201
+4012	PF02340	PRRSV_Env		PRRSV putative envelope protein	Bashton M, Bateman A	anon	Pfam-B_939 (release 5.2)	Family	This family consists of a conserved probable envelope protein  or ORF2 in porcine reproductive and respiratory syndrome virus (PRRSV) also in the family is a minor structural protein from lactate dehydrogenase-elevating virus.	25.00	25.00	27.00	29.20	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.51	0.70	-5.19	4	222	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	9	0	0	236	0	230.50	83	92.22	CHANGED	Mh.hSSLhPhLI.hF.hsFCLu.PSPsGhW.hhSDWFuPRaSVRs..hT..sYRR.acshlp.CpPDl.paG.Kt.hGMLWHMKVuThlD-hlppRlhppMpHpGptsWtQVhoctsLppIushslVsHhQplAulEtEuCpYLhSRLPhlpshussh.NVTIpa...LNpshhI..uPuspshhss.+.WLlShpSSlFSSVAAussLaIVhhLRlP..RpVFGFhahpts++o	.................................MLSRs.WCPLLISSYFWPFCLAS.SPVGWWSaASDWFAPRYSVRALPFTLSNYRRSYEAFLSQCQVDIPTWGsKHPLGhLWHHKVSTLIDEMVSRRMYR..IMEKAGQAAWKQVVSEAT.....L.....SRIS.uLDVVAHFQ.HLAAIEAETCKYLASRLPML.H.NLRhTGSNVTIVYNSTLsQVFAIFPTPGSRPKL.HDFQQWLIAVHSSIFSSVAASCTLFVVLWLRIPhLRoVFGFRWLGAhF......	0	0	0	0
+4013	PF01366	PRTP		Herpesvirus processing and transport protein	Bateman A	anon	Pfam-B_1171 (release 3.0)	Family	The members of this family are associate with capsid intermediates during packaging of the virus.	20.30	20.30	24.90	24.60	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	638	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.96	0.70	-6.53	32	211	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	109	0	0	193	0	587.10	37	83.17	CHANGED	htQcLsAlhuQlpshshplplL+hCDPss..h...hphsslphNshhlphLpcplhstLtpQs.phpsosLoltLphhLcshptcsttlhpuLp...p............tppaFppsh...tLs..ttCshHpplplshYG.sttlslplshlNDlEphLKpLNhsahhlsspsulpslpplhpFLschhGsuslssP-lYssop.PCh.Ca-ELslssNQGcolp+RLhsphCsHlspph....lpsth-s.lpplshshshsspch.......t.ht......................htspptpsps..................hhppAtphLcsaslFp.ssstplYplS-LpYWsuoupt...............tsshcthsssLspLhp+Epphcthpstl.phhlhscsspHFhchatsp.............sh-pLasGuhhsSs--hI-ALhpsChspahspPhhpcLhppps-hhstLpplLpphp............................sssssssststs...................................................t....phst.ttsp.t......................................................pshp-sphR+ctYhc+lo+cuhspLtpClcpQcc.LpKhLslsVaGsslhcphsplhNtFhtRptalpts.htst........spssstsF-sppal+ssLhppplssphLssLsppFacLlNGPLhscs.chFs.PsNssLhasl-ssGlLPHhKp-Lschhhsshps.pDWhsspFppFYsF....ss...pslsssQ+hs	....................h.hQ+LhslhupsppashplEhL+hCDPpl..hh..tc.sshKhNuhtlhhLh+plhPtlhtQs.ptp.o.LolhLchlLcthhc-sthL.tuLtsat......t...t.D.........httaappsh...tLs....CshHpplpLphhs.ss.hshpLshLpDlEpFLpphNasahlhsspsultshtplhphLtphsGhu.ls..Elas.up.sCh.CaEELslhsNQGcolp+RLtshlCsHlshp....pspsp.-s.hppl.pshh..stchs...tslsslct.....................l.upsss.ps...................hhp-ApthLctaslFp.shstplYulS-hpaW.tou.................pshhcths.slppLshhcp.hhcthhssl.phtLaGcpscch.thhtt.tls...........h.-plhlGuhhsuPschI-hlhphshpta.ssPlhp+L.p.ppp.hstl+plLpclp......................................s............s......................................................t...................................................................shtthhppstp-sphR+RtYhp+lSchuhuplh+Cl+pQcp.lpKhlcVNlhGplhhchhuplhNGFhhRppahpts...ss........shusthsaDtHhalhssLl++plssthLPtLspphacLlNGPLFsHspcpas.P.Nsshhaus-NsGlLPHlK--Ls+hh.u............ssts...s-WhVscaptFasF......ss..hpslsshQ+th.............	0	0	0	0
+4014	PF02666	PS_Dcarbxylase		Phosphatidylserine decarboxylase	Bashton M, Bateman A	anon	COG0688	Family	This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65.   These enzymes catalyse the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2.  Phosphatidylserine decarboxylase plays  a central role in the biosynthesis of aminophospholipids by converting  phosphatidylserine to phosphatidylethanolamine [2].	20.00	20.00	20.20	20.30	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.26	0.71	-5.02	112	3949	2009-01-15 18:05:59	2003-04-07 12:59:11	10	31	3153	0	1299	3080	1984	203.70	27	63.28	CHANGED	hstaFsRth+sst..Rsl......stsss..........hllSPuDGplhth...l.....tt................h.hKt...hthtphlss..................................................................................................................ps..shhlslaLuPtDYH+h+sPssGplpp.hpahsGch...................h...............................sss.hthpp.................................................pNERshhhhp......hu.t......hhhltluuhhlspIhhth.t.........................................................................tstplp+GcchGhFph.GSsllllh.ts.h..................p.plphGp.plphGps.ls....t	..................................................................................................hstFFsRhl+sss........R..s..l..............spsss..........................hlluPADGt.l......sph...sp.l..p..ttp................h..h.KG...ta.shppL.Lus...........................................................................................................................................................................hps..shhsslaLuPtDYHRhHhPss.G.p.l.p.c....h.hahs.Gc.h........a.........................................................sVs.hpupp..............................................t.h.h.s.c.N.E....Rshhlhc.......sphG..............................hshl.VGAhhVupIhh..sh......................................................................................................ptu.plp+Gc-hGhF+h.GSTl.l.l.lhstst.....................p...p..lp.....sp...hsphGptlh.t.........................................................................................................................	0	425	811	1087
+4015	PF04230	PS_pyruv_trans		Polysaccharide pyruvyl transferase	Kerrison ND, Finn RD	anon	COG2327	Family	Pyruvyl-transferases involved in peptidoglycan-associated polymer  biosynthesis.  CsaB in Bacillus anthracis is necessary for the non-covalent anchoring of proteins containing an SLH (S-layer homology) domain to peptidoglycan-associated pyruvylated polysaccharides.  WcaK and AmsJ are involved in the biosynthesis of colanic acid in Escherichia coli and of amylovoran in Erwinia amylovora [1].	25.30	25.30	25.40	25.40	24.80	25.20	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.77	0.70	-4.70	163	2481	2012-10-03 16:42:30	2003-04-07 12:59:11	8	39	1781	0	656	2150	297	275.20	15	70.68	CHANGED	NhG.Dtl...........hhuhhphLpptt..psplhshs.......t.ttttthht.h...............................................................................................lllsGu...................................t.....hh..........hhhhhhtpthpp.h.......lhhutuh...................t...h..............ppttpp...hhpphhpp.hsh...lslR-ph.Shp.........htphsh.......psthssDss.h..hht..................................ttthhthtptst................t.thtphhhhhhphhhp.pthphhhh.ht.t.t.t..p.h............................h.hh...hsspchhshls.pschllssRhHuhlhuhhhshPsl.slsh.ss	................................................................................................................................................................................................................................NhG.s.h....h....hhuhhph.l....pp.........t...p....h....ph.shs......................t....t.t.....h.ht.h...h..................................................................................................................................................hlhsGu............................................h..h............hthhhhsth.hpp...h.......................hhhutul...........................us..ht.................................stthpp...........hhp.hh..hsp..ssh.....lslR-ph.Shc......hhpphslp................psphssDss.h......hls.......t...t..........................................................htthh.http.t...............................tth..t..pt.hhthhph..hhp.........pthp.hhh.h..s..hth.t...t........p.h..........................................................thh.h.h...t.hs...st...ch.hph...ls..psch.slusRhHuhlhuhhhshPhl.sls.........................................................................................................................	0	230	461	572
+4016	PF00223	PsaA_PsaB	psaA_psaB;	Photosystem I psaA/psaB protein	Finn RD	anon	Prosite	Family	\N	19.00	19.00	20.60	19.50	17.90	17.50	hmmbuild  -o /dev/null HMM SEED	684	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.30	0.70	-6.45	22	3289	2009-09-12 09:11:12	2003-04-07 12:59:11	14	18	1996	14	178	2825	824	538.70	58	96.78	CHANGED	FSpsLApsP.....TTphIWphhAsAHD.F...-oHsu.s.Epl.pKlFuuHFGHLAlIFlWhSG.hFHsAh.uNapsWlpDPhpl+P.ApslW.PhhGQphls......scsGush...shhssSGlaphWhshGhsophpLhtsulhhLlhAulhLaAG............WhH.hp.th........................PpLtW........FpssEShLNHHLuuLhGluSLAWuGHhlHVAlPhsphhcs.............hsshhpl.PhPpsL.......................sPFFohNWutYup..................hLTFpG.....G...LpPtTGuLW..LTDlAHHHLAIAllFIlAGHMYRTsa.GIGHshKEll-upps.................hs.uHpGLa-hlssShHhQLulsLAhlGolo.lVApHMYuhPsYsYlupDYsTphuLaTHH.aIuGFlhVGAhAHuuIFhVRDY..DPthN..........tsNlLsR.......lLcH+-AIISHLsWVslFLGFHohGLYlHNDoMpAhGcPp.....ptI.lpPlFAQaIQuhp..upsh........sssu....s......s.s.hhsG....lsuls.scss.hhl.lGsuDFLVHHhhAhslHsTsLILlKGsL.ARuS+LhPDKtshGapFPCDGPGRGGTCplSuWDphaLulFWMhNoluhVhFaapWKh.S.hhGss................................................upFspSShhlsGWLRDaLWtpSSQlIsuYssh.....LSsauhhFLhuHhlWAhuhMFLhShRGYWQELIEolVWAHpKh.lAstI.......pPhALSIsQGRhVGlsHahlGsIhThhAFhlA	............................................................................................................................................................................s.Ecl.pplFuuHFGQLuIIFlWhSG.hFHsAh.uNapuWlpsPhpl+P.ApslW...PhhGQ.hlp.............scsGush.s..hhSGhaQhWhs.GlpophpLYssAlhhLhh..uulhLhAG............WhH.hp.th........................PplpW........FpNsEShLNHHLuGLhGluSLuWsGH.lHVulPhs+h.cs.............hss.h.-l..Ph.Ppth....................................sPFFohsWs.Yup..................hLTFhG.....G...h.pP.TtuLW..LTDhAHHHLAIAlLFll.AGHMYRTNa...GIGHShK-lLEAHpsP..................hhGpGHKGL.Y.-hl.ss.ShHhQLulsLA.lGslo.lVA..pHMYuhPsYsalApDasTQhuLaTHH.aIuGFhhsGAhAHuAIFhlRDY..sPp..ps..........hsNl....LsR.......hLcH+-AIISHLsWsslFLGFHohGLYlHNDsM.AhGpPp.....p.tI.lpPlFAQWIQssH..uhsshsh.....................ussu......u............spo.h.hh.sG......l.sAls.sp.s...h.lslGs.uDFLVHHhhAhslHsTsLILl.......KGsL.ARuS+L...hPD..KtshGapFPCDGPGRGGTCphSsa.D.t.h....................................................................................................................................................................................................................................................................................................................................................	1	36	97	152
+4017	PF02531	PsaD		PsaD	Bashton M, Bateman A	anon	Pfam-B_1336 (release 5.4)	Family	This family consists of PsaD from plants and cyanobacteria. PsaD is an extrinsic polypeptide of photosystem I (PSI) and is required for native assembly of PSI reaction clusters and is implicated in the  electrostatic binding of ferredoxin within the reaction centre [1]. PsaD forms a dimer in solution which is bound by PsaE however PsaD is monomeric in its native complexed PSI environment [1].	22.40	22.40	24.20	24.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.57	0.71	-4.97	20	196	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	148	6	61	196	124	127.70	66	81.82	CHANGED	ssLssps..PhFGGSTGGLL+uAEsEEKYAITWTSpKEQlFEMPTGGAAlM+cG-NLLYLARKEQCLALuT.QLRs+F..KIpDYKIYRI..FPsGEVpYLHPKDGVFPEKVNtGRtslGpssRpIGpNsNPsslKFoGK.psa-	.............Lssps..PhFGGSTGGLLppApsEEhYsITWsSsKEQlFEMPTGGAAIMpcGpNLLhLARKEQCLALG.T.QLRoKF..KIpcYKIYRl..FPsGElQYLHPKDGVaPEKVN.GRptVGps.RpIGcNssPhplKFoGKtsa-.......	0	19	43	56
+4018	PF02605	PsaL		Photosystem I reaction centre subunit XI	Bashton M, Bateman A	anon	Pfam-B_1741 (release 5.4)	Family	This family consists of the photosystem I reaction centre subunit XI, PsaL, from plants and bacteria.  PsaL is one of the smaller subunits in photosystem I with only two transmembrane alpha helices and interacts closely with PsaI [1].	25.00	25.00	40.70	39.20	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.99	0.71	-4.69	21	179	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	141	6	63	174	145	149.10	48	79.09	CHANGED	pphlpshs.DPhVGsLuTPlsoSsho+sFIsNLPhYRpGLSPhhRGLElGMAHGYFLhGPFshLGPLRN.o-hAhlAGLLuulGLllILTssLohYGsls.........spsssh....................................-sLpTpcGWupFsuGFhlGGsGGAhaAahLlpsh.l.ts	.........h.phlpPhssDPhlGs.LtTPlsSSshsthalsNLPAYRpGlSPlhRGLElGhAHGYhLlGPFshh...GPLRs.o-hAthAGhLuAlGLVlILTlsLolYGhsuFpp......spssss...shsh...p..........................s.-sLpTscGWupFouGFalGGhGGuhaAahLltslth..sh........	0	20	47	59
+4019	PF00737	PsbH	PSBH; 	Photosystem II 10 kDa phosphoprotein	Bateman A	anon	Pfam-B_465 (release 2.1)	Family	This protein is phosphorylated in a light dependent reaction.	20.80	20.80	20.80	21.30	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.50	0.72	-4.39	19	1173	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	1095	17	62	665	119	39.10	76	66.99	CHANGED	pTtLGslLKPL.NSEYGKVuP..GWGTTPlMulhMsLFhVFLlIILpIYNsSllL	........TslGslLKPL..NSEY.GKVAP..GWGTh.hM.............................	1	14	42	56
+4020	PF02532	PsbI		Photosystem II reaction centre I protein (PSII 4.8 kDa protein)	Bashton M, Bateman A	anon	Pfam-B_1731 (release 5.4)	Family	This family consists of various Photosystem II (PSII) reaction centre I proteins or PSII 4.8 kDa proteins, PsbI, from the chloroplast genome of many plants and Cyanobacteria. PsbI is a small, integral membrane component of PSII the role of which is not clear [2].  Synechocystis mutants lacking  PsbI have 20-30% loss of PSII activity however the PSII complex is not  destabilised [2].	19.30	19.30	19.50	25.70	18.50	17.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.58	0.72	-4.33	15	674	2009-09-11 13:22:19	2003-04-07 12:59:11	9	2	643	17	44	216	33	35.40	85	96.30	CHANGED	MLsLKlsVYsVVlFFVuLFlFGFLSsDPuRNP..sR+D	.....MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRcE......	0	13	31	40
+4021	PF01788	PsbJ		PsbJ	Bashton M, Bateman A	anon	Pfam-B_1227 (release 4.2)	Family	This family consists of the photosystem II reaction centre protein PsbJ from plants and Cyanobacteria.  In Synechocystis sp. PCC 6803 PsbJ regulates the number of  photosystem II centres in thylakoid membranes, it is a predicted 4kDa protein with one membrane spanning domain [1].	21.20	21.20	21.20	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-7.91	0.72	-4.42	25	1304	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	1239	17	50	454	91	31.80	78	95.70	CHANGED	Mus...TGRIPLWlVuTVuGluslullGlFFYGSYuGLGSSL	......MAD..TTG.RIPLW..l.IGTVsG.I.VIGLlGlFFYGSYSGLGSSL......	0	14	34	45
+4022	PF02533	PsbK		Photosystem II 4 kDa reaction centre component	Bashton M, Bateman A	anon	Pfam-B_1331 (release 5.4)	Family	This family consists of various photosystem II 4 kDa reaction centre components (PsbK) from plant and Cyanobacteria.  The photosystem II reaction centre is responsible for catalysing the core photosynthesis reaction the light-induced splitting of water and the consequential release of dioxygen.  In C. reinhardtii the psbK product is required for the stable assembly and/or stability of the photosystem II complex [1].	25.00	25.00	25.50	25.50	23.10	22.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-7.99	0.72	-4.02	25	756	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	711	17	53	470	13	40.60	78	72.83	CHANGED	shllAp..LPEAYuhFcPlVDVLPlIPlhFhLLAFVWQAAVuFR	..s.hFFuK..LPEAYAhhsPIVDVMPVIPlhFFLLAFVWQAAVSFR..	0	13	35	46
+4023	PF02419	PsbL		PsbL protein	Bateman A	anon	Pfam-B_1884 (release 5.4)	Family	This family consists of the photosystem II reaction centre protein PsbJ from plants and Cyanobacteria. The function of this small  protein is unknown. Interestingly the mRNA for this protein requires a post-transcriptional modification of an ACG triplet to form an AUG initiator codon [1,2].	19.70	19.70	20.40	20.40	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.29	0.72	-7.54	0.72	-4.53	14	1035	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	985	17	49	215	89	36.70	90	86.43	CHANGED	pssNPNppsVELNRTSLYhGLLLlFVLulLFSSYhFN	...TQSNPNEQ.NVELNRTSLYWGLLLIFVLAVLFSNYFFN.....	1	14	32	41
+4024	PF05151	PsbM		Photosystem II reaction centre M protein (PsbM)	Moxon SJ	anon	Pfam-B_6558 (release 7.7)	Family	This family consists of several Photosystem II reaction centre M proteins (PsbM) from plants and cyanobacteria. During the photosynthetic light reactions in the thylakoid membranes of cyanobacteria, algae, and plants, photosystem II (PSII), a multi-subunit membrane protein complex, catalyses oxidation of water to molecular oxygen and reduction of plastoquinon [1].	21.10	21.10	21.40	21.40	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.06	0.72	-4.35	19	1155	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1094	17	44	275	4	26.80	81	83.33	CHANGED	MEVN.LGFlAolLFlllPTsFLlILYlpTsu	......MEVN.LuFIAosLFILVPTAFLLIIYVKTVS..	0	11	30	40
+4025	PF02468	PsbN	psbN; 	Photosystem II reaction centre N protein (psbN)	Mian N, Bateman A	anon	Pfam-B_2222 (release 5.4)	Family	This is a family of small proteins encoded on the chloroplast genome. psbN is involved in photosystem II during photosynthesis, but its exact role is unknown.	20.40	20.40	20.60	20.50	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.16	0.72	-4.34	32	1871	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	1799	0	52	442	322	43.00	83	95.48	CHANGED	ME...sAhhlsIhluslLlulTGYulYsuFGPPS+pLcDPFE-HED	.........ME...TATLVAI.ISsLLVSFTG.YALYTAFG.QPSpQLRDPFEEHtD...	0	14	38	48
+4026	PF04725	PsbR		Photosystem II 10 kDa polypeptide PsbR	Kerrison ND	anon	DOMO:DM04871;	Family	This protein is associated with the oxygen-evolving complex of photosystem II.  Its function in photosynthesis is not known.  The C-terminal hydrophobic region functions as a thylakoid transfer signal but is not removed [1].	21.80	21.80	21.90	23.50	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.37	0.72	-4.00	5	100	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	62	0	33	95	1	92.70	63	71.49	CHANGED	SGuKKlKTD........cPY......GhGGGMsl+sGVDASGRKuKGKGVYQFVDKYGANVDGYSPIYoP-EWSPSGDVYVGGTTGLhIWAVTLAGLLuGGALLVYNTSALAs	..................................usKKIKTD..............pPa......GhuGGhsl+sGlDASGRKuKGKGVYQFVDKYG.ANVDGYSPIYss--WSsoGDVYsGGsTGLhlWAlTLuGlLuGGALLVYsTSALu.........	0	8	21	29
+4027	PF01405	PsbT	PSBT; 	Photosystem II reaction centre T protein	Bateman A	anon	Pfam-B_1880 (release 3.0)	Family	The exact function of this protein is unknown. It probably consists of a single transmembrane spanning helix. The Swiss:P37256 protein, appears to be (i) a novel photosystem II subunit and (ii) required for maintaining optimal photosystem II activity under adverse growth conditions [1].	20.30	20.30	20.50	20.50	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.89	0.72	-6.96	0.72	-4.36	3	1892	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	1795	17	44	477	0	27.70	90	83.23	CHANGED	MEALVYlFLLlGTLuVIFFAIFFRDPPRI	....MEALVYTFLLVSTLGIIFFAIFFREPPK.V..	0	12	31	41
+4028	PF03912	Psb28	PsbW; 	Psb28 protein	Finn RD	anon	DOMO:DM04467;	Family	Psb28 is a 13 kDa soluble protein that is directly assembled in dimeric PSII supercomplexes.  The negatively charged N-terminal region is essential for this process [1]. This protein was formerly known as PsbW, but PsbW is now reserved for Pfam:PF07123.	25.00	25.00	56.40	56.40	18.70	17.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.38	0.72	-4.09	34	184	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	126	1	63	178	102	103.70	44	82.25	CHANGED	IQFhcGlsEpllP.-VRLTRS+.DGssGpAhFhFcpPps..lst.pt.s..-ITGMaLlDEEGEltTR-Vpu+FlNG.....cPpulEAsYhhcopp-W-RFMRFMcRYApsNGLuas	.IQFhpGlsEpllP-V+LTRS+.sGssGsAhFhF-pPps..l-ptps..p.tsITGhaLID-EGElsop-VsuKFlNG.....cPptlEutahhco.p-W-RFMRFMcRYuptNGLsa.....	0	18	45	59
+4029	PF00849	PseudoU_synth_2	YABO;	RNA pseudouridylate synthase	Bateman A	anon	Pfam-B_421 (release 3.0)	Family	Members of this family are involved in modifying bases in RNA molecules. They carry out the conversion of uracil bases to pseudouridine. This family includes RluD Swiss:P33643, a pseudouridylate synthase that converts specific uracils to pseudouridine in 23S rRNA. RluA from E. coli converts bases in both rRNA and tRNA [1].	23.80	23.80	24.10	23.90	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.13	0.71	-4.41	57	25319	2009-01-15 18:05:59	2003-04-07 12:59:11	17	48	4782	26	5572	17465	6565	147.20	25	50.03	CHANGED	ph.lllsKPtGhsspsts............................thtthhth.hhtt..tpttphthlpRLD+sooGlllhupssphspplpp.h....tppp.lcKpYhuhl.............................................h...ptshhp..h..............................................................................ssptshshhcslpps.........................................sphshlplplhoG+pHQlR...tphst	.............................................................................................................................................................llllNKPtGhlspsss......................................................................................................t..t..h...h..h..h..h..h.h.t........ttst...c..h...hhVt..RLD+..........-ToGL...........ll..l..s.p.s..s.pht.p.pLtc...............................p+p....l....p....K....pY.hAhVp.....................................................................................................................................................................t...t...t....h...l..p...t...s.l.tp.................................................................................................................................................................................................................h.....h.....h.....h.....h...h....p....s....u....p...s.......u....h...o...p.h..chlpph.............................................................................................t.s.h..ohl..c.lplp.p....G..RsHQlR...hhht.........................................................................................................................................................................................................................	0	1812	3469	4634
+4030	PF00796	PSI_8		Photosystem I reaction centre subunit VIII	Bateman A	anon	Pfam-B_528 (release 2.1)	Family	\N	19.80	19.80	19.80	19.80	19.40	19.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.46	0.72	-6.76	0.72	-4.36	36	650	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	624	7	44	352	15	23.70	74	61.13	CHANGED	LPSIhVPlVGLlhPAlsMulLFlaI	.LPSIFVPLVGLVFPAIuMA.LaLal...	0	11	31	39
+4031	PF02427	PSI_PsaE		Photosystem I reaction centre subunit IV / PsaE	Bateman A	anon	Pfam-B_1594 (release 5.4)	Domain	PsaE is a 69 amino acid polypeptide from photosystem I present on the stromal side of the thylakoid membrane [1]. The structure is comprised of a well-defined five-stranded beta-sheet similar to SH3 domains [1].	20.90	20.90	21.40	23.50	19.50	20.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.19	0.72	-4.60	25	181	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	147	11	65	180	119	62.20	61	69.39	CHANGED	lpRGSKVRILR.ESYWap-VGTVAoVDpoG..l+YPVlVRF-KVNY.......uGlNTNNFAhcEL.clt	...pRGuKV+ILR.ESYWaN-lGoVsoVDpuu..l+YPVlVRF-KVNY.......uGlsTNNFA.cElpcV.............	0	19	45	58
+4032	PF02507	PSI_PsaF		Photosystem I reaction centre subunit III	Mian N, Bateman A	anon	Pfam-B_2122 (release 5.4)	Family	Photosystem I (PSI) is an integral membrane protein complex that  uses light energy to mediate electron transfer from plastocyanin to ferredoxin. Subunit III (or PSI-F) is one of at least 14 different subunits that compose the PSI complex.	21.10	21.10	21.80	22.00	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.15	0.71	-4.72	10	178	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	141	6	65	172	142	142.20	43	86.29	CHANGED	phhAllhL.slhls....sPssusADlAGLsPCpESsAFpKRtKsolK+LpppLtpY-PsSuPAlAlptph-+TKpRF-pYupAGLLCGsDGLPHLIsDG....RaoHAGEFllPGlLFLYIAGWIGWVGRuYLlAVpsocc.PT-KEIIIDVPLAlKhhhsGFsWPlAAhpEatSGcLlA+D-	............................................t....hhh.shhh.......s.....shs.ph..us.LTPCp-S.tFtp+tptthppht......tstos............ptRF-pYups..LCG.s.DGLPHLIssG.........chs.HhG-FllPulhFLYIAGWIGWsGRsYLhslp..p.p..cp..ss.pEIIIDVPLAhphhhpGhhWPluAhpEhhsGcLhtp-.s.......	0	19	42	58
+4033	PF03244	PSI_PsaH		Photosystem I reaction centre subunit VI	Bateman A	anon	Pfam-B_3007 (release 6.5)	Family	Photosystem I (PSI) is an integral membrane protein complex that uses light energy to mediate electron transfer from plastocyanin to ferredoxin.	25.00	25.00	25.40	25.40	18.80	16.60	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.72	0.71	-4.94	6	67	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	39	4	27	66	2	124.50	62	96.53	CHANGED	olssVpPo.slKGLAGSSluGtKLtl+su.huh.+ssppRAsuVVAKYGDKSVYFDLEDluNTTGQWDlYGSDAPSPYNsLQSKFFETFAuPFTKRGLLLKFLlLGGGSLlsYhSusuutDl.LPIp+GPQpPPclGP....RGKI	....................ssspPs...s.lpGLuGSS....lsGpKLsh.+Pupp.uh...+sps......h..RuuuV.VAKYGDKSVYFDL-DluNTTGQWDLYGSDAPSPYNsLQSK.FFETFAuPFTKRGLLLKFLlLGGGuhlsYhuusuosDl.LPIK+GPQ.PPp.GP....RsKl...................	0	8	20	25
+4034	PF01701	PSI_PsaJ		Photosystem I reaction centre subunit IX / PsaJ	Bashton M, Bateman A	anon	Pfam-B_1599 (release 4.1)	Family	This family consists of the photosystem I reaction centre subunit IX or PsaJ from various organisms including Synechocystis sp. (strain pcc 6803), Pinus thunbergii (green pine) and Zea mays (maize). PsaJ Swiss:P19443 is a small 4.4kDa, chloroplastal encoded, hydrophobic subunit of the photosystem I reaction complex its function is not yet fully understood [1]. PsaJ can be cross-linked to PsaF Swiss:P12356 and has a single predicted transmembrane domain it has a proposed role in maintaining PsaF in the correct orientation to allow for fast electron transfer from soluble donor proteins to P700+ [1].	20.50	20.50	21.20	21.30	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.85	0.72	-4.19	31	684	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	652	7	51	324	19	36.80	72	80.63	CHANGED	Mps...hppYLSTAPVluslWhshTAGlLIElNRFFPDhL	......McD...lKTYLSsAPVLuTLWFuh.LAGLLIEINRFFPDAL..	0	13	38	47
+4035	PF01241	PSI_PSAK		Photosystem I psaG / psaK	Finn RD, Bateman A	anon	Prosite	Family	\N	20.60	20.60	21.00	21.30	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.66	0.72	-3.97	9	219	2009-01-15 18:05:59	2003-04-07 12:59:11	13	1	131	9	87	209	97	76.60	33	73.61	CHANGED	s..sshVhslshsssLhsstFGhhshpp+ss...usslPhss.............t.........ssGFsLs-lLAhuSlGHllusullhGLpshGsl	.............................................t...oshlhhl.hssslhAhthGhhshpppss......u.ss.lP.ts.............................uGFs...ls-lLAssSlGHIlGhGllL.GLushGs.....	0	19	60	81
+4036	PF00421	PSII		Photosystem II protein	Finn RD	anon	Pfam-B_182 (release 1.0)	Family	\N	20.10	20.10	20.20	20.50	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	437	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.55	0.70	-5.89	19	3769	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	2075	40	249	3264	956	386.90	46	96.73	CHANGED	hGhsWapspshllNssG+LlusHlhHsuLlshWAGuMsLaElAhFsPpc....PMacQGhhlLPahApLGhssu.GG.slss.shhssG...........h.tlhuotllh.GhlFhAhlh.....sh.-.hchFt..hshcsthcLspIhGIHLhLhGlhsFhhshhthhhshs.shWss...DshslTs.s.ssAshaGh.shsPFsssG..........llutHIhsGllsIhuGlaHlhs+P.thhh+AL.hhshEshLS.SlAAlhhhuFlsushhWYsssAhPsEhaGPTt.phsQ...pQthphhVc.....stpLutshush.t.huhhcYlhpSPutthlFt.Gth.+h.slttsWLt.hhh.s..G...................lDhstlhps..Pap...p+huhE..........................Yhp+A.LGpl.phstsshp.suV.hsSPRuWhohuHhshAhhFFhGHLWHuuRshh..shAGh-tslscplEhshh.KlhD	.........................................hll..N.....s..G+LlusHlhHsuLl.....shWAGuMsLaElAhFsPpc....PMacQGhhllPahspLGhssu.GG....sl.ss.h..shhssG............................h.tlhuutllh.GhhahAhlh................sh......-...........h..........hFs.............hshKsp.chspIhGIHLhL.GlusFhhsh.htl....hh....h....hs.shWss........DshtlT................s..h...s.....ss.s..sh.....aG..h...h.......h.s...P..F.s..stG..............IhutHlhhGhlsIluGlaHl.s.+.......P.t...h..h......h..+............uh..........h....h.............shEshLS..SlAAl.hhuFlssshhWasssshP.EhaG.PTt.phsQ........tQth.hhhVp................s.pLutshuph.t.huhhcYlh.psPstthlFt.Gph.ph.sltssWLt..hh.s..G..................................lDh.stlh+s..Pap...p+hSsE..........................Yhp+A.LGpl.plsts....shc.suV.h.sSP...RuWhshuHh.huh.h.hh.GHlWHuuRshh....hG.........................................................................	0	50	157	222
+4037	PF04012	PspA_IM30		PspA/IM30 family	Bateman A	anon	COG1842	Family	This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homologue in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator [2].	32.00	32.00	32.10	32.10	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.43	0.70	-4.99	11	2762	2012-10-03 05:15:35	2003-04-07 12:59:11	7	5	1843	0	615	1709	167	219.40	26	93.85	CHANGED	slasRltcll+uslschl-chEDPp..+hL-QtlR-hcsplscu+pslAphhApp+phEcclcptpppspchcppAptALstG..............pEpLA+EsltchpshcppspshcsphsptcststpL+pplspLEsKlpph+scpphLtARtpsA+Appplppphushs...ssuAhsphcRhcpKlt-hEsptputupht...........psts....hDtclcptthptss....cpsLupL+utpsp	...................................ulFsRhtcllpuslsshl-..c..sE..D..Pp..+hlcphIp-.hccpLscscpssAcslAppKphpc+lcptptphtchpp+A....ph..A.Lpps....................c-sLA+t...ALtcptphpshl.pshc...pphsphcsshspl...ccp.l..schpp+lsch+..s.+.pp.s.lh..u...........+pp.sAp...........up..p..p..ls...p...p.h..suhs.........hs.s.Ah...tp.h-ch...c.......c+...l..pp....hpAcu.cutspht...............t.ts.............L-pch...uph.tt.ssth............pp.LApL+t....ht...................................................................................	0	180	388	505
+4038	PF04839	PSRP-3_Ycf65		Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)	Kerrison ND	anon	Pfam-B_2979 (release 7.6)	Family	This small acidic protein is found in 30S ribosomal subunit of cyanobacteria and plant plastids.\	      In plants it has been named plastid-specific ribosomal protein 3 (PSRP-3), and in cyanobacteria it is named Ycf65.  Plastid-specific ribosomal proteins may mediate the effects of nuclear factors on plastid translation.  The acidic PSRPs are thought to contribute to protein-protein interactions in the 30S subunit, and are not thought to bind RNA [1].	25.00	25.00	45.80	45.40	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.56	0.72	-3.91	24	145	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	125	1	52	140	129	48.90	60	35.66	CHANGED	LTsYFFWPRsDAWEplKspLEuKsWIsps-+lpLLNpsTElINaWQEps	...LTsYFFWPRcDAWEpLKscLEuKsWIocp-+lplLNpATElINaWQ-p.G..	0	11	35	47
+4039	PF03034	PSS		Phosphatidyl serine synthase	Griffiths-Jones SR	anon	Pfam-B_1414 (release 6.4)	Family	Phosphatidyl serine synthase is also known as serine exchange enzyme.  This family represents eukaryotic PSS I and II which are membrane bound proteins which catalyses the replacement of the head group of a phospholipid (phosphotidylcholine or phosphotidylethanolamine) by L-serine.	25.00	25.00	26.10	25.60	19.60	18.30	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.96	0.70	-5.00	18	319	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	164	0	208	305	10	251.10	42	61.24	CHANGED	PHPAhWRlVhuhuVlYllhLsFLLFQshcss+plh.talDPc.Ltp.ls.c..+pYuts.Cphhossc.......lhpp.hDhFshAHhlGWhsKslllRcahLsWslSlsFElhElTFpHhLPNFpECWWDplILDVLlCNuhGIhhGhhss+hLch+pYcWsul+.......................ch.o..hpGKhKR....hlhQhTPpShst.....................acWtshpo....hpRFhtlhhllhlhhlsELNsFFlKalLthPPsH.lslhRLllashlussulREaYsYl..sDs.pp++l.....GspsWlhhulhhhEsllslKhutp	.....................................PHPAhWRhlhGhuVlYhl.hLhFlLFQ.shpss+phh.halDPp.Lt.......h..h...E....cpYus..s.Cp....lhs.-p...........lhsp.hDhFshuHhhGWhh.KslhIRshhls..WhlSlh..aElhElsFtHhLP.NFsECWWDp...........lILD.lL.lCNuhGIahGMhsscaLch+pYc.Wtulp..............................................................ph.o...hpGKhKR........shhQFTPtsWst.....................hcWhs.pu....hpRhh......tlhhhhlla..l...sELNTFFLKalhhhsspH.lshhRllhhshlsssslRpaYsal.........sDs....sK+l.....Gpp..sWlhhsI....shhEhllslKau.s...........................................	0	90	117	167
+4040	PF01515	PTA_PTB		Phosphate acetyl/butaryl transferase	Bateman A	anon	Pfam-B_799 (release 4.0)	Family	This family contains both phosphate acetyltransferase and phosphate butaryltransferase.  These enzymes catalyse the transfer of an acetyl or butaryl group to orthophosphate.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.76	0.70	-5.37	21	7061	2012-10-02 21:08:39	2003-04-07 12:59:11	14	23	3973	31	1389	5144	3674	287.60	33	59.22	CHANGED	phhchlhcpAc......stpp+IllPEGp-tRlLcAAptlhppGlAp.slLlG..s..-lpt.h.thtlphth.hplhsspss.th.ccasspahchRKpKGhTh-tAcchlp.DsshhushhVchGpADGhVsGsspoTucslRsuLQIItstsGspllSulFlM.hs............cthhhauDCAlsspPsu--LA-IAlpoAcsA+ths.hcP+VAhLSaSThGSucupss-+VtpAspls+ctpP-L..slDGElQhDAAlspcVAppKsPs.SsluGpANVhlFPsLpAGNIuYKlsQRhuphpAlGPIlpGhspPlNDLSRGsSscDIlNssAlTA	....................................................................................h.....lhphup......tt..t+lV..hsE..G..p-.RslcAsthhhpp.sl.sp.slLlG....s..cl.pt..h..t..h..t...h..t......l....p...h........s.........s...hplls...s......p...s..s..................c...p...h.....ht..t....h..h..p..h.tp..t+..........h.........T.......p...Apchlp...csshhushhVptGc......ADuh..l..s.G.sl.p.os.upsl+sslpl.I.t...s.t.s.G..s...p...h..sSuh.h.hh.hhs............spshhhuDsulN..............s.............P..s..............u.cpLA...-IAlt.u.Ac.os.....c..t.F.G............h..-....P.+VAhLSa.Sshs.S.u....p.......s....s....s..........s...p+sppAs.c.ls............c....c..........t..........t..........P.....-.......L.......hlDG..hphDAAls.p.l.up.pK.....h.P.s.....Ss.l.s.G..p.A.slhlFPsLpuGNlsYKhlp.p.h.u...s..h...h.ul.G....PlL..............Ghpp.PVpsLSRusssc-llphsslss..........................................................................................	0	423	876	1160
+4041	PF02126	PTE		Phosphotriesterase family	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR001559	Domain	\N	20.00	20.00	20.00	20.00	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.65	0.70	-5.41	4	1183	2012-10-03 00:45:34	2003-04-07 12:59:11	13	6	947	100	216	791	85	301.20	34	95.71	CHANGED	lshuphGhTLsHEHlphshsuFhpshPptassppt..........................psuthhpcLtch+A+GVcslV-hTshslGRslphltcVuctTslpIVAuTGhYh.sshP........usphcSVEpLTphhlcEIpaGI-sTuIKAGIItphssu..tlTPhpE+VLcAsApAptpTGsPloTHTutu.ttGhpQhtIhppcGlDlSRVslGHsD.spsDls.LhchhshGsYlthDph.....Ghps.........h.s.pcRlthl+tLhDcGahc+lllSpDhpphacuhhpshhshu.......hsa....l.sslIPtL+p+GlopcsLcshLl-NPppahp	...................................................................................thsshGhTLsHEHLh.h.....s.h..u.s...hh..p........s.s..s...p..t...h.s...........................................................ph.ptshtElps...h....h.s.h.G.sco....lV-hT.s.t..s.hGRss...phltcVu.cc..T...G..lNlVuu..TG...a....Y...h...c...th...h...s...................p.t.l..t.pp.o..V.....c.p.....LAphh.lcElpp....G............I..............s..........s..........T......s......l..........+....A..Gl..I.u..E..l....usu....stl.T.h..Ec+..........shpA.AAhAp.pp.T.G...sPl....ssHs.s....hss...h..G.h..E......lc.l.......L..............p...cp.GV.c.s+...Vsl.u...H.sD...p.....pp..D..............h.....s..h..h..hc..hh..c.h..G.sa..lpFDtl.............hhp.t.......................h.hP..-.pcRl.shlttLh-c.Ga.tcpllLStDl....sp.............c....t....h....h.ts.s.s.G.hG..........asa........l.s....sFl..P.tL....t....p....p....G..ls....psp.l....c....ph.hl-NPuphhp................................................................................	0	78	132	176
+4042	PF00809	Pterin_bind	DHPS; 	Pterin binding enzyme	Bateman A	anon	Pfam-B_1411 (release 2.1) and Pfam-B_3423 (release 6.6)	Domain	This family includes a variety of pterin binding enzymes that all adopt a TIM barrel fold. The family includes dihydropteroate synthase EC:2.5.1.15 as well as a group methyltransferase enzymes including methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) Swiss:Q46389 that catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation. It transfers the N5-methyl group from methyltetrahydrofolate (CH3-H4folate) to a cob(I)amide centre in another protein, the corrinoid iron-sulfur protein. MeTr is a member of a family of proteins that includes methionine synthase and methanogenic enzymes that activate the methyl group of methyltetra-hydromethano(or -sarcino)pterin [2].	25.50	25.50	25.70	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.29	0.70	-4.96	42	8265	2012-10-03 05:58:16	2003-04-07 12:59:11	17	42	4552	134	2104	6541	3687	202.90	28	37.28	CHANGED	llNlosDSFu-Guphhs.pt.slpp..........AcphlppGAcllDlGupuo..tP...........shlsscpEhpRllPllctltt..............sl.lSlDThcsclhctALct.GuchlNDstuhp........p.chhplstchss..slVlMHhp..................spshtpp...phc.-llp-lhphhptp.ht.h..sGls..pcllhDPGl..GF..u+s.pcshtllpplsc.........htth....shPlLlusSRKshlu	.........................................................llNls.cSFssG..u.....p.....h....h.....p......h......t..h.....s..hp.c...................................Ac.phlp..p.....GAs......lIDlGs.-us....tP..t.................s..l..s..s.c.cE...h.pRlls.....l.l.....pultp...................................clslSlDo.+scVhct...uL....c....s....G....u...c......h...lN.Dshuhp.........................p.ph..hpl..s...t.c.....h..u.s........slllMahp..........................................................p.s.....t..cs.........sph..c.................-.l..hp.....clh.p.hhtpp.h..h......sG.ls..ccIllDPu.hsF..........uts......c...c.s.h..t.l.l..p.p.l.pt.............................hpth................shs..l.l..hGsSpKthhu...................................................................................	0	718	1410	1818
+4043	PF01091	PTN_MK_C	PTN_MK; 	PTN/MK heparin-binding protein family, C-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.70	21.20	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.63	0.72	-3.99	10	216	2009-09-12 05:24:01	2003-04-07 12:59:11	13	5	76	1	107	213	1	60.10	45	38.44	CHANGED	GA-CKYcFpsWGECDusTGhKoRoGoLKKALaNA-CQpTVoloKPCsptsKsKspu...KKGcGK-	...........Gu-CKYpF..p.uWGECDssTuhKoRo.GoLK..+...uhh.sAsCpp..TlsloKPCsptsK....sK..pt.......pKtp............................	0	19	28	65
+4044	PF05196	PTN_MK_N		PTN/MK heparin-binding protein family, N-terminal domain	Finn RD	anon	Manual 	Domain	\N	20.00	20.00	22.80	22.80	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.32	0.72	-4.00	6	140	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	45	1	55	116	0	58.00	63	38.71	CHANGED	KKEKsKKshtuS-CuEWpWGsClPNStDCGhGhREGT.....Cs-pT+KlKCKlPCNWKKcF	.............KKEKscKps.tt..S-C..u.EWpWu.sCVPoSGDCGlGhREGT.....Ccpph+p.+CKIPCNWKKpF...........	1	4	9	25
+4045	PF04387	PTPLA		Protein tyrosine phosphatase-like protein, PTPLA	Mifsud, W	anon	Pfam-B_1525 (release 7.3)	Family	This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types [1].	21.20	21.20	23.80	22.00	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.17	0.71	-4.82	70	686	2009-01-15 18:05:59	2003-04-07 12:59:11	9	16	312	0	448	652	10	151.90	32	59.31	CHANGED	Qsh.AllEllHuhlGlV+Ss.lhsThh.............................QVhuRlhllaulh..hhhPpsps.......................p.shshhlluWSloElIRYuaYshsl....hshs..PthLsWLRYohFhlLYPlGls.uEhhh.................lapulsh............h...sthshuhtah.......................hhLhhhLlh.....YlPG..hhhlYsaM...ltQR+KhLtptp	.......................................................................................Qsh.AllE.....ll.H.....s.h.lGlVpos.l...hsThh.............................QVhuRlhllas.lh..t..sh...phps..................................p.slhhhlhuWols.........Ell....RYsaYshsl.............hs.hh......PthLpWL.RYohFllLY...PlGls.uEhhh.................latulsh...htt.......t.hs...h.h......P.th.sh.s.h...pah............................hh..Lhhhhhh................YlPs....h.hh.ahaM...hpQR++hlt...t..............................................	0	128	210	344
+4046	PF01242	PTPS		6-pyruvoyl tetrahydropterin synthase	Finn RD, Bateman A	anon	Prosite	Domain	6-Pyruvoyl tetrahydrobiopterin synthase catalyses the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin, the second of three enzymatic steps in the synthesis of tetrahydrobiopterin from GTP. The functional enzyme is a hexamer of identical subunits [1].	21.30	21.30	21.50	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.77	0.71	-4.43	149	3812	2012-10-01 20:59:24	2003-04-07 12:59:11	14	10	3101	68	1103	2685	1412	126.40	30	87.70	CHANGED	pls+c.hpFsAAHpLh.sht...............GcCpp.l..HGHsaplclplpup........hscsG...hlhDFsclKphlpp.lhp.p..hDHphL.N...-hsthtt..............................................P..TuEslAtalacpLpptl..........thpltp.lclh..E.ossshsp..ap.tp	..................h.lh+c.hpFpAAHpL...phs.........................t+Ctp.l..HGHoahVclplpGc.h....................scsG......h.lhDFuc..lK.phh+...lhc....p.......hD...HphL..N.....-h.sth..ps.....................................................................................P..TuE....slApalapplpstl................splp.p..Vplh..E.Tssshs.ap.................................................................................	0	366	700	933
+4047	PF00854	PTR2		POT family	Bateman A	anon	Pfam-B_571 (release 3.0)	Family	The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.02	0.70	-5.68	25	7665	2012-10-03 03:33:39	2003-04-07 12:59:11	16	26	2595	5	2449	6215	1113	304.30	20	67.32	CHANGED	apTIhhuullYslGhslhsluuss.sh...............s.sht..............hshhaluLhlIulGTGulKPsVSuFuuDQF-.csp...ctppspFFshFYhuINsGSLlushhsshlp........pphsasluFGlsulsMllulllFhhGpthY+ph..tss.hhhs...hlshllsshh+ptthths...ttthlhhs....hpphs................pthhppphhtsp.......sshlhhshshhhshh.....sp.spsthlptlhhhhtlh.hhhlh.sphhs.huhhhlt.lsthphhlhs.hplsssphsshsshslllhlslhshllsshsp.....hphshohhh+hulG.hhhthushhssh.................................................lph.....thssstuhsss.....hhhl.shhhhhthsplhlpusu.s.....hhh.phhhspt.shhpuhhhhhpssss	..................................................................................................h..slhhu.uhl...h.h..l...........Ghhh......h..s..h.....th....................................................................................................................hha..hu.l.h.h..l.s.lG..s.G.......hh....K...........sshushhuc....ap...tp.........................c.ph....su....hF.shaY....hu.l.NlGuhh.u.h.hsshlt.................................................................pp..hu.a.t...h..uF...s...l.s..s..h..u.hh...l..u.ll.......h.a......h..h......s..t.....t.......h.....h..........h.....t.........................s.........hp...................ht.h..h.....h...h.....h......h..h..h......h...h.........h..................................h........h..................................................................................h..h...........h.h...h.............................h.h.......h............h...................................t..p..p...h......hhhh..hh.h....h.h.....h....h....h.....hh...h..h.t....p...h...............s..t.......h.s....h..h.......h........p........s.p...........t.................................h.......h.......s...................h...........p.........l.................s.ss...h.p..s...l.sshhl...h.l....h.ssl...hshlhh..hhp..........................t.s.h..h.+.huhG.........h....h....h..hh.uh....h..h..h..hh..............................................................................................................................................................................................................................................hth...............hs...t...t..t..s....hs...................hhl.......hhhh..hsphhlssl..u.s..................hhh.phh.tt.h.s.hhuhhhhh.h..h..........................................................................................................................................................	0	540	1303	1941
+4048	PF00381	PTS-HPr		PTS HPr component phosphorylation site	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.36	0.72	-4.09	168	8181	2009-01-15 18:05:59	2003-04-07 12:59:11	14	41	3582	89	1297	4207	498	83.30	31	35.45	CHANGED	h..hp.tpl...sltsttGLHARPAuh..lVptAspF..suclplt.ps.s....ppssAKSlhulhsLustpGsplplpscGp.........DtppAlpsltpllp...st	.......................ptphhlt.sppG.LH..ARPAsh..lVpts....ppF......su-lplp...pp..s.......cpssu....K...S....lhulhs..Lu..ltp...G..splpl.p..A.c.Gs.........................D..t.ppAlpslsphhpt.t.......................	0	417	759	1033
+4049	PF01885	PTS_2-RNA	DUF60; 	RNA 2'-phosphotransferase, Tpt1 / KptA family	Enright A, Ouzounis C, Bateman A, Kerrison ND	anon	Enright A	Family	Tpt1 catalyses the last step of tRNA splicing in yeast.  It transfers the splice junction 2'-phosphate from ligated tRNA to NAD, to produce ADP-ribose 1"-2"-cyclic phosphate.  This is presumed to be followed by a transesterification step to release the RNA.\	\	\	    The first step of this reaction is similar to that catalysed by some bacterial toxins.\	       E. coli KptA and mouse Tpt1 are likely to use the same reaction mechanism [1].	20.90	20.90	21.20	22.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.26	0.71	-4.99	88	1070	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	913	1	404	881	94	168.10	38	78.73	CHANGED	sp...ppt.sclSKhLShlLRHt.spchGLplDppGal..slspLlpthpt......p..sht.h.....shpclpplVpss-KpRFplp..................................................................................................................................sstpIRAsQ...GHSlp.Vc......Lph...sspt........................PthLaHGTspcthssIhppG..Lp.MsRpaVHLoss.............................hpsuhhsG...tR+.sssVllhlDspphh.psG............hpFahSsNsVhLoc......tl	....................................p..pp.sphSKhLSalLRH.........t..Ppt........hG.........l..s..lD.pcG..as..slccLl..tthp.t..........t......shp...l..........oht.lcplVts....s-....Kp......RFshp.......................................................................................................................................................................t.s.s....tpI.R..AsQGHSh.p...Vs........h.....sptt..................................sPthLaHGTspchh.spIhp.pG..Lhth.....p.Rp.....aVHLS..ss............................................ttsAhhs.G...tR+..sssVllhlcspphh..pc..G............l.Fa.upNGVhLos.......sls...................................................	0	144	252	336
+4050	PF00358	PTS_EIIA_1		phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1	Finn RD	anon	Prosite	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.62	0.71	-4.60	14	7674	2012-10-02 20:27:15	2003-04-07 12:59:11	15	18	2590	18	868	4397	51	132.00	41	27.04	CHANGED	ssstslsoPlsG-llsLspVsDpVFuuchhGcGhAIhPosGpVhAPlcGsltplFsT+HAlGlpS-sGsEILIHlGIDTVcLcGcGFpuaVppGscVctG-hLlpFDlstlcpsuhshhoPlllTNoscassl	...........................s...plhuPl.sGcll.sLs.cVsDsVF.u.pchhG-GlAI....c...P........o.....s.....G......p.........l..h...APs.s.Gplsp..l.F.s.T.p.HAlGlp...o.....-..s....G......l.......E.......l.LlHlG.l.DTVp..L..c.....G...c........G......Fp.sh.V..p.pGpcVp.sG.shLlphDlshIcp.su.h.ssh.oPVl.lT.Ntspht..h...................................................	0	230	456	653
+4051	PF00359	PTS_EIIA_2		Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.97	0.71	-4.47	153	18510	2012-10-02 23:31:29	2003-04-07 12:59:11	17	113	3409	21	2010	9683	678	141.30	21	36.45	CHANGED	p.hhspphlhh.s..php...scpcslphh...sp..hLhcp..s.........hlpst....hhpslhpREc...hhsTsl....s..su.........lAlPHsc........t.t...lp.......cs..sl.slsphpp.sl.pa....s............tt.Vcllhhlssscsst............alp..hLsplsph.l...tspph.....hppLh...p.sps.pclhp.llppt	.........................................................................................t..hptp.lhh.sh..psp.....sppcslchh...sp..hL...h..pp...s........................hlpss.........ahpu.ll....p...R..Ep....t..hs.Thl....s........su........................lAl.P.Huc....spt.....lp.......cs...sl.sls..p....h.p..p..sl..pa...s.............t.-..spsl.p..l..lhhlusssspp............Hlp...hLspLs.ph.l....tc..c..ph.....hpp...Lh...p..sp..s....p.clhp.llt..t........................................	1	621	1143	1577
+4052	PF00367	PTS_EIIB		phosphotransferase system, EIIB	Finn RD	anon	Prosite	Domain	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.50	0.72	-4.71	138	13320	2009-01-15 18:05:59	2003-04-07 12:59:11	15	22	2535	8	1413	7412	51	34.90	43	6.63	CHANGED	AppllpslGGpcNIpslspChT.RLRlsl.....p....D..pstls	.........AtpllpulGG....p-NIs..slsp.C.h.T.RLRlsl.....p.....D..pspls..............	0	324	668	1027
+4053	PF02378	PTS_EIIC		Phosphotransferase system, EIIC 	Mian N, Bateman A	anon	Pfam-B_639 (release 5.2)	Family	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.	26.80	26.80	26.90	26.80	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.05	0.70	-5.61	55	25880	2012-10-01 19:13:17	2003-04-07 12:59:11	13	36	2821	4	2482	14149	266	300.10	17	57.49	CHANGED	tcuhhhslPlllsuulllslus.................................thhs.h..hhptsusssFshLsllhuhulAhsl..t.......sssssss.uuhluhlsh.h...hshhhh..t......................................hsshhshhhsspGhhuullsullsshlaphhhp...h.h+lPcslshhs.....uptFsslIsshhshllhuhlhthlhshhpsslhs.h....h.......hhtssshhushlhuhlhphlhhhGlHtshhsshhhtsh...........hhh....s..hh................................hh.tt.h............hhhGssGssLAhhhshhhtp+spptptlspuuls.......................shlhGIsEPl.Fuhshlhshl.hhlshllsu	............................................................................................................................puhh.hlshlls.u..G...l....llulst......................................h........................................t.h.h.t.s...h...h.....t.h....h...t....h.h..u..s...s......s......F..s....h...ls........l...l....h..uhsh..u....h....sh.........................s.ss..sh...h...s.....u..s.h.h...u.h.ls..h...h......................................................................................................................................h....h..h......h....s....s...s....Gh....huu.l.l.su.hl.uu..h....l.h...p.h.hpc..............h...cl.....P....p...s...l...s..hhh........s.h.h...ss....l....lss...h....h...s....h.h...l...h....u....h..l....h...t....h.l....h.....s..h...l..s..s.s.lt.s.............h...............ltsts....hh..u...s.h.l.h.u.hl.hth.hh.h.h...G.l.Ht.s.h.s....s.s.hh.h.hhh........................................................hh.........................................................................................................................h.h.............hh..hu....s..s..u...s....s.....lu.h...h.h...s....h....h....h....t....p..+.......p..p.....t....t....p..t..h...hs.u....uls.....................................s.h.l.h.G.lsEPh.....auhsh.shs....h..hlsshlss............................................................................................	0	606	1215	1835
+4054	PF02255	PTS_IIA		PTS system, Lactose/Cellobiose specific IIA subunit	Bateman A, Mian N	anon	Pfam-B_3710 (release 5.2)	Domain	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a  variety of metabolic and transcriptional processes.  The lactose/cellobiose-specific family are one of four structurally and functionally distinct group IIA PTS system enzymes. This family of proteins normally function as a homotrimer, stabilised by a centrally located metal ion [1]. Separation into subunits is thought to occur after phosphorylation. 	20.80	20.80	20.80	21.30	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-9.98	0.72	-4.12	110	4200	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	1842	38	343	1558	6	94.80	39	88.68	CHANGED	EphshplIhpuGsARStshcAlptA+pG-accA-phlppApctltcAHphQTpLIppEAsG..s+hphollhlHAQDHLMouhsh+-LspEhI....cLa+c	............lshplIhtuGsARSphhEAlpt.A.+p..G..-.F..p.pAcphlppApp.s.lhcAHcsQT.p.LlppEA..sG...s.c.h..p..lollhlHAQDHLMTohhhp-LhcElI-La+c.................	0	79	164	248
+4055	PF03714	PUD		Bacterial pullanase-associated domain	Yeats C	anon	Yeats C	Domain	Domain is found in pullanase - carbohydrate de-branching - proteins. It is found both to the N or the C terminii of of the alpha-amylase active site region. This domain contains several conserved aromatic residues that are suggestive of a carbohydrate binding function.	25.00	25.00	26.00	25.40	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.50	0.72	-3.88	39	1526	2009-01-15 18:05:59	2003-04-07 12:59:11	9	80	727	16	186	1138	23	104.40	26	14.47	CHANGED	psplplHYpR....sc..usY-sWsLWlW.s-ssssss............hs.......pshshstp-c.YGsahslpLspsspp....lGFllpps...sspD.........usD+hlsh....ptsptlWlhpGspplahsps	.................s.shhRlHYp+..........ss..usY..........-shuLWhW....s-spsssp..................tWs........tshph.stpDc.YGtYhcl..pl...s..s..s..t..sp..........lu...Fllpss..........ptps......hstD.......hpl.....c...hh.....t........shs..p...l...Wlh-sDtplYhp........................	0	48	96	146
+4057	PF03829	PTSIIA_gutA		PTS system glucitol/sorbitol-specific IIA component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	26.60	25.80	24.20	22.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.51	0.71	-4.42	35	1216	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	908	2	104	427	58	117.30	39	95.66	CHANGED	Msh.....lYpoplspIGs.Apphlp-.pMl..IlFs-sA.Ps-Lt-aChlHphs..p...hpsslpsGshlplsspsY.ITAVGslAppNLcpLGHlTlpFDG.spps-hPGolalps...ps..sslphGs..pIp	.......Mph.lYposIscIGspAp-hLs-...pMl..IhFsE.s.A.Ps-Lc-aCaIHspu.....p....hpss..lpsGsphslup.ppYslTAVGslAppNLc-LGHlTLpFDG...hs..-..s..chPGsl+..Vss.....ss....s..cIssGshl.h.................	0	31	55	83
+4058	PF03830	PTSIIB_sorb		PTS system sorbose subfamily IIB component	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.70	21.70	23.30	22.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.84	0.71	-4.35	122	5348	2009-09-11 23:04:30	2003-04-07 12:59:11	10	6	1539	14	422	2069	35	149.20	34	73.55	CHANGED	pIshsRlDsRLlHGQVustWspphssspIlVlsDplA...pDclpcshlchAs.PsGlphplhslpcslcshpssp.hssp+lhllhcsPpDslcllcuGl....slcp..lNlGshphpp....G+cpls..p.slslsppDlpsh+cLppp.Glc.lplptlPs-spt...s	............IsLsRIDsRLIHGQVustWspph.ssspIlVss.DpVA.............pDslp+sll.chu.s..PsGlphplhslp..Kslc.shps.sp..h..sp.p..+lhllhcsPpDshcl.l.-.u.Gl....s.l....c.p.....l...NVG..sM.......uh..p.p......G.+p..p..ls......p.slslsccDlpshccLppp.Glc.lplptVPsDst...........................	0	108	241	337
+4059	PF03209	PUCC		PUCC protein	Mifsud W	anon	Pfam-B_2839 (release 6.5)	Family	This protein is required for high-level transcription of the PUC operon.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.31	0.70	-5.75	11	317	2012-10-03 03:33:39	2003-04-07 12:59:11	10	5	173	0	127	1156	603	383.60	31	84.17	CHANGED	TLNRVMIVELAVPAslVulMlALPhLhAPFRsLhGa+SDo+tSALGa+RsPYIWhGolh.hGGhAlMPFAlllLos..ps...tsPtWhGhhsuulAFLhlGsGlHhsQTsGLALAsDluscEsRP+VVGLhYVMLLlGhlloAlhhGhLLss...................as.u+LIpVlpGsulsshVLNllAhW+.Estp.tps.....t.cscpcPsht-AWtphs.upspAhphLhslhLGThuFsMpDVlLEPYGGpVlsLsVupTTpLTAhhuhGsLlGFhhuuhsLupGhcshphAshGshlulsuFhhllhuuhhs..s..hslFhsGshhlGhGuGlFutuTLTusMpLAstspuG...lALGAWGAsQAoAAGluhhlGGslRDllpths.........t.suhuYshVaulEhhlLllolhhhssllcsptt	.............................................................................................................................................................................................TLNRVMIl.E..LulP.Ahlsu.hh.lul...hh.h.uP..h..R.shhGatSDspt.hhGh..+R..sPa.Ihh..Gshh...h..s.G..hh....l.h....s.....h.....u..l...h...h...lu..s...................sh.h.....h...Ghh.h.usluF...l...hh...G..hGl.....p..ss.pT.shLA.....LhsDhs....s.t...c....p.R.......s.p.ll.ullas.M.......h....l..h.Gh.h..l..o......Ah.lhG...t..l..Ls.s.........................................................a.o......t..+.L....lp...V...l..p.s....su.......l....l....s....h..s....L....s.....h....l.A..lW..t.Et...+..tstts.................ttsp..p....s....Ft...p...s...h.t..phh......spsps.....tph..hhh.l...hl.us.hu.a.......h..Q.D.l...l......L......E...PY.G.Gp.l...huh..o...l...u.p.TT.p.....Ls.....A.h.h.u...s...G....s.Ll..Ghh...h....s....u....h...h....l..s.....t...t.h.s........h...p...h....s...t....h...G..s..h.h..u....hhu...h...s...h...l..l...h....u..u.hs.........s......sh.hhtsu...s..hll..Ghu.sGlaususl..os.h.M.sl..s...s...t.....s......p.....sG.......lhlGsWG....A.s....Q..AhAtGluh.h.l.GGs.l.tD.......ls..p...thss................s..sshuY.u...hVat.l..Ehhlhhs.u.lhhlh.lsht...t.........................................................................................................	1	27	64	92
+4060	PF00806	PUF		Pumilio-family RNA binding repeat	Eddy SR	anon	[1]	Repeat	Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA).  Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognise all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats.  Structures of PUF repeat proteins show they consist of a two helix structure [3,4].	21.20	18.60	21.20	18.60	21.10	18.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.47	0.73	-7.78	0.73	-4.18	50	6866	2012-10-11 20:00:59	2003-04-07 12:59:11	14	49	324	360	4462	7032	23	33.70	25	20.65	CHANGED	phpsplhpLsp.cpaGshllQ+hl-h.tstpptphlh	............splhpLsp.DpaGshVlQ.....+hl-t..ss.ppt....................	0	1426	2555	3719
+4061	PF02245	Pur_DNA_glyco		Methylpurine-DNA glycosylase (MPG)	Bateman A, Mian N	anon	Pfam-B_3352 (release 5.2)	Domain	Methylpurine-DNA glycosylase is a base excision-repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA.	21.00	21.00	26.40	21.00	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.20	0.71	-5.14	149	1752	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1672	8	481	1305	356	183.20	36	88.25	CHANGED	spp...Fa.spsshtlAccLLGphLlpp..t....st.lsG........pIVETEAYhG......sD.AuHuapG.pTs.........RspsMFGssGphYVYhhYGhHaChNlVstscGh.usAVLIRAlEPlp.Ghph....hp.....................tpR.h................t..................................ppLssGPG+LspALuIsts.tsGtsLss.......ss........................lhl...........sss........hss..........tp..l.ssusRIGIs....cus-hPWR.Faltussh	.....................tFh.spsshpl.A+pLLGt..hLhtp.....s...t........tt.hsG........hIVEsEAYhG......s.DtAuHuatG...pTs.........RspsMas...sGplYlYhhaGhHhhlNlVsp.s.c.G.h.spuVLIRAlEPhp.Ghph.......ht..................................................................tpRtt.........tt..........................................thpLssGPGKLspALu.Ishp.hsGtsLts...........ss..........................................lhl.............ppt....................................t.s..tp..l.hsusRIGIs.....csschPhRahlpGss................................	0	157	292	393
+4062	PF04845	PurA		PurA ssDNA and RNA-binding protein	Mifsud W	anon	Pfam-B_4535 (release 7.6)	Family	This family represents most of the length of the protein.	24.60	24.60	24.70	24.70	23.80	24.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.46	0.70	-5.23	6	296	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	121	4	173	276	3	177.70	43	73.55	CHANGED	pQELASKplcIQsKRFYLDVKQNsRGRFlKIAEVGsGG......pKSRlhLShsVAsEh+DpLucF.-aYApLu.....ppttp..pp.......................pptLKSEhllRDsRKYYlDLKENpRGRFLRIpQTshRG.........s.spcQpIALPAQGhIEFRDALscLI--YGss........p-..uELPEusslpVDNKpFaFDVGSN+aGVFhRlSEVK..ssYRNSITVPhKsWs+FscpFscYsEcM	.......................................................ppLAo+.lplQpKRFYlDVKps.+GRFlKlAElh.st..........................p+u.plhLuhssA.th+p.Lsph.chhspls..........t.t....tt.................................hLKo-hl.p-pR+YYhDLKENtRGRFLRlp....Qshs.s.....................tttppIslPAQGhlEFRDALspLl-caG....................tt....-....LP.....Eupsl....p..V..D.sK.pFaFDlGsNch.GlFlRlSEV+....ssa.RsoITlP.....h.....csWscFtphhscas-c.......................................	0	40	74	120
+4063	PF02700	PurS	UPF0062; PurC;	Phosphoribosylformylglycinamidine (FGAM) synthase	Mian N, Bateman A	anon	COG1828	Family	This family forms a component of the de novo purine biosynthesis pathway. 	21.30	21.30	21.30	21.30	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.58	0.72	-4.03	102	1833	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	1819	26	504	1114	1244	77.80	38	68.30	CHANGED	ac.scVhVoL..KsuVLDPpGpAlcpALppLGaps.VpsVRlGKhlElplpss.spppAcpplcchC-+L.LANPVIEsYch.-lpc	...........lpVpVpLKsuVLDPQGpAlpp.A.L.p.p.L....G..ast.Vpc.VRhGKhh..-lpl-s.s...st.p..tscsplcphs-cL.LANsVIEcYphcl..........	0	167	348	442
+4065	PF00855	PWWP		PWWP domain	Bateman A	anon	Bateman A	Domain	The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif [1]. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organising higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression [2].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.28	0.72	-3.78	273	2569	2012-10-02 16:56:36	2003-04-07 12:59:11	12	117	297	46	1417	2476	10	92.50	23	11.99	CHANGED	hpsG.-lVWu....K.h...cGa...P..hWPuhlhs.t......................................pt......t......t...p...........tt.........tsph.............................h....VhFFu...sp.p......a..u.....al..p..t.pp.lhsap......pt..p...............pp............h...pp.................p............p...cp..................psh...ppAlppAt...pt	.....................................................u-lVWu....K.h......cGa.........P...aWPAhl...hs.........................................................................t...t..............p.........tt............tsph.............................h..VhFFG.......sp..p..............h..u.....al..s..........p.p.lh.sap.....ppp..................p.p............h.tt..................t............p..pp....................ttappAltch...t.............................................................................................................................	0	323	550	943
+4066	PF02436	PYC_OADA		Conserved carboxylase domain	Mian N, Bateman A	anon	Pfam-B_628 (release 5.2)	Family	This domain represents a conserved region in pyruvate carboxylase  (PYC), oxaloacetate decarboxylase alpha chain (OADA), and  transcarboxylase 5s subunit. The domain is found adjacent to the  HMGL-like domain (Pfam:PF00682) and often close to the biotin_lipoyl domain (Pfam:PF00364) of biotin requiring enzymes. 	20.60	20.60	21.20	21.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.28	0.71	-4.88	139	3341	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	2687	38	837	2634	637	192.00	34	23.79	CHANGED	VhhaplPGG.hoNLtsQhcp.GhtD+hc-VhcphscVpc.lG.lshVTPoSplVGs.Alh.Vhs.......................sc.+hhshsppVhsahcG.hGpPPushscclpp+lL.ps..ccs..osRPu-hLpP.-h-plcpElpp.h............h.............sc-DlLoYsLaPpVstcFhct+pphssht.hss....................hhhshphspphp...lcl-..Gcshhlcl	........................................lhhtplPGG.....hoNLppQh+p....Ghs-+a--Vh.c.thscVpp.hG.lshVTPoSplVGs.Alh.Vhs.......................................sc..chhshscplhshhpGch.Gp.s.sus..hs.pc.Lp.p...plL..cu.........p..c..sl....Ts..R....P..............u..-....h..L..pP....-..hc..p..l...c..p-ltchh....t..t.....h......................sc-DlloaAlaPplh.....hcahct......+p......p..h....s..s.h..p....l.sp..t.............................hh....s....t....s..p.php...lplp.Gpthhlp....................................................................................................	0	304	553	729
+4067	PF03013	Pyr_excise		Pyrimidine dimer DNA glycosylase	Griffiths-Jones SR	anon	Pfam-B_1388 (release 6.4)	Domain	Pyrimidine dimer DNA glycosylases excise pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond. Pyrimidine dimers are the major UV-lesions of DNA.	22.10	22.10	22.50	22.30	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.85	0.71	-4.38	26	421	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	392	7	56	317	25	114.10	37	90.02	CHANGED	MphhppsLlscLscppLLupaREhstl..............+ssuhtpcHhTl............shhFhpp.hhLhphathlhcEMpcRG...YpsstpWhs............tpapGchsPs....hhshpclttphPhhsc+.p.Yhpps	.................Mphhpp.hhlscLscppLLupHREhsul..............+usuhs.p+hTl............shhFhtpshhLhphHthlhpEMppRG...Yps.s.p..Wh..-..................paR.uchpPs....h.shtcl.....t.p....hshhscast.Yhtt................................................	0	21	32	43
+4068	PF01948	PyrI		Aspartate carbamoyltransferase regulatory chain, allosteric domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The N-terminal domain has ferredoxin-like fold, and provides the  regulatory chain dimerisation interface.	25.00	25.00	46.80	45.80	18.50	17.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.25	0.72	-3.96	60	1268	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	1241	116	234	645	96	95.50	52	59.80	CHANGED	cpcLpVpsI+sGTVIDHIsAGcu........LpVLclLs.lp..ssstploluhNlsSp+hG+.KDIlKIEsph.Lscc-lsplALlAPpATlNII+-YcVVcKhplpl	..c.pcLpVEAIKpGTVIDHIPAphG........hKlLpLF+Ls...cocpRlTIGhNLPSsch..G+..KDlIKIENsF.......Lo--plspLALaAPpATVNhI-NY-VVpKp+.......	0	65	137	188
+4069	PF02748	PyrI_C		Aspartate carbamoyltransferase regulatory chain, metal binding domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	The regulatory chain is involved in allosteric regulation of aspartate carbamoyltransferase. The C-terminal metal binding domain has a rubredoxin-like fold and  provides the interface with the catalytic chain.	21.80	21.80	21.80	23.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.08	0.72	-4.53	70	1294	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	1268	116	241	677	90	51.10	47	31.64	CHANGED	cplpGl..l+CsNsNCITs..s.EPVpopFtV..hp.pshpL+CcYCE+hhscpclhp	.........-cIssV..ltCPNsNCIo+...s.EPV.s.S..s.FtV...........pcsscltLKC+YCEKcas+p.V..t.....	0	70	143	195
+4070	PF01243	Pyridox_oxidase		Pyridoxamine 5'-phosphate oxidase	Finn RD	anon	Prosite	Domain	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.76	0.72	-3.97	141	8674	2012-10-02 11:35:36	2003-04-07 12:59:11	15	54	3619	83	2886	8805	4127	89.20	19	47.13	CHANGED	lsp..php....phlp..p................phssLAT....ss..t-..GtPpsphhh..hhhstsp...........hhhhhsstpu......p+spsltpsPc.lulhhh.tp.........h..t.ptlp...l..pGpuchlsctp	............................................thtthlt..ps...............ps..hh.lA.T................ss......tc..........G.....p......P....p.....s.....phhh......ht..h.hstp...............................hhh..h..h...o...s..t..t.u.........................p+....s....p.p.l..........p....p......s......P....p....lu..l.......h..hh..p.................................ht.ptlp.....l.....pGp.uphlpt.....................................................	0	870	1911	2492
+4071	PF00282	Pyridoxal_deC	pyridoxal_deC; 	Pyridoxal-dependent decarboxylase conserved domain	Finn RD	anon	Prosite	Family	\N	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.97	0.70	-6.02	11	7254	2012-10-02 18:26:03	2003-04-07 12:59:11	14	35	3273	90	2360	6947	942	298.70	24	67.83	CHANGED	PGYL+t...hlPtsAP.csEshppIhpDhcchlhPGlopWpsPpFauaaPsssSh.uhlu-hLssuINssGFoWtsuPAsTELEhlshcWluchltLPttFhtp.t...GGGVlQsouSEusLlullAARp+hhpch+tps........huKLVsYsSDQsHsSl..cKAutlusVc...h+hl.scp..phthpspsLccAIEcDhppGhlPhaVsATlGTTsssuFDslpcluslspc......aslWlHVDAAYAGoAhICPEaRp...hhpGlEpADShshNPHKahlshhDCoslWV+-cstL.pshphss.YLppsp...shssDhtcapIshuR..+hculKlWhllRuaGlcsLpspIRcphphAphhpshlppDsR.FElss...chthuLVCFRlK	.........................................................................................................................................................................................................................t......h........................................................sh.s.....h..h.p..h.......P.t...h.s.....lE.......hhlshl.s.p.h.h.....t..h...s............................................us.Gs....hp..s.u.u.o...pus.hhu.....h....h.........s.h+......t......p.......h......h.....t......p......h...t.t...t..t..............................................htc.....s....hh.s..u.pp..s.H...h...s.h....cK...s...u....t...h....h....s...lt..........................lp....l....s....st.........pt...t.h.p...............h..t..s...l.c...p.t.....l...p....................t...........s........p......p..............h................................h.......l................l.....u...o..h..G.......oT......sG.....s.h.....D.....s.....l....p....t....l....s..s....l...t..p.c...............................h..s...l...a...lH.V......DA..A.h.u...G.....................h..........l......s......s........hp...........................h.ht.l.....p...........t.......s.c..S......lshss..HK.......ah.h.ss.....h.ssu...hh...h..h.+.p....p....h...h......p..........t..h........h...p...s........Y..L..t...................................................................................................................................................p.......h..h.......p...h.......tl...h.u.R................t...h...h...p.ha...hhc....h..G..h...p...s...htthhpp.........t...........ht.......hAthht..p.....l....t....t..................h..lh............h.s.....l..h.......................................................................................	0	695	1263	1924
+4072	PF00719	Pyrophosphatase		Inorganic pyrophosphatase	Bateman A	anon	Pfam-B_613 (release 2.1)	Domain	\N	21.90	21.90	21.90	22.00	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.63	0.71	-4.78	157	4053	2009-01-15 18:05:59	2003-04-07 12:59:11	14	17	3177	158	1242	2843	708	156.90	40	75.74	CHANGED	ssl...lEIPpsop.sKYElDKcsshhhlDR.............hhass.....htYPtNYGalPpTls......................sDGDPlDlLVlss.tshhsGsllcsRslGlLpMhD-.....uttDtKlluVsss...Dsta.p...slpclp-ls.thlppIpcFFcpYKsLc......psKhl..plpsatstctAtchIpcuhppa.pp	..........................................slIEIPtsup...hKYElDK-o.G....t...lhlDR.............hhhou......hhYP.sN.YGalPp..TLu............................tDGDPlDV.LV.ls.s...hP.l.h.P.G.s.V.l.c.s.Rsl.GlLpMtDE........ustDtKllAVPts....c.pa..s.......clcD..l...s...Dl...s....t.....hh...hppIp..HFFcpYKsL-.................tsKaV..c.l.psa.tstctApt.Ihpuhcphp.t.......................................................	0	391	752	1029
+4073	PF02547	Queuosine_synth		Queuosine biosynthesis protein	Mian N, Bateman A, Eberhardt R	anon	COGs	Family	Queuosine (Q) biosynthesis protein, or S-adenosylmethionine:tRNA -ribosyltransferase-isomerase, is required for the synthesis of the queuosine precursor (oQ). It catalyses the transfer and isomerisation of the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to form epoxyqueuosine (oQ-tRNA).  Q is a hypermodified nucleoside usually found at the first position of the anticodon of asparagine, aspartate, histidine, and tyrosine tRNAs [1,2]. In Streptococcus gordonii , QueA has been shown to play a role in the regulation of arginine deiminase genes [3].	25.00	25.00	25.30	25.20	21.70	24.10	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.28	0.70	-5.72	110	4206	2009-09-10 15:09:34	2003-04-07 12:59:11	10	5	3721	5	867	3069	1946	327.50	45	97.57	CHANGED	pls-FDacLPpELIAQpPsp.....RcsSRLLllcpp..........ss..t....lpcpp.Fp-lschLpsGDLLVhN-T+VIPARLaGpK......t.....oG..................G+lElL......lhch......h...t...........ttt........a.s..hl+su+ch+sGsplhh..........st.......sh.....pupVltp...tpt..sth.llphphpt..........shhphLcchGc.....lPLP.PYIcR...................ts........stt...Dp.cRYQTVa..A....c..csGuVAAPTAGLHFoppLLppLppcGlphuhlTLHVGhGTFpPV+...s-clpcHpMHuEahplspcssptIpps+.tpGtRllAVGTTslRsLE.o.......A......upp.........Gt...........lpshpGcT-lFIhPG..YpF+lVDsLlTNFHLP+STLLMLVSAFuGp-plhpAYpcAlccc.......YRFaSYGDAMLIh	...................................p.lsDFcFcLP-c.L.IAphPht..................pRssuRLLl...l...ctp...................su.....p...l.p...c.p...p.FpDll-..hLp.......sGD...hLVhNsT+VlPARLaGpK..............t.......oG.............................................u+l...ElLl.+............................h...s...scp..........h.s.........hl+.......s.........u........K.............+........h.........K........sG...s...pl.hh...............s-...................................pl.pA.p.hh.tchpp........ttt....lhch.p..ass.....................h.h-lLpplGc.....hP.L.P.P.Y.I..cc...............................................t......-..t........Dp-cYQTVY......A....c...c.....G.ul..AAPTAGLHFocpLLpclcsK.GVchsalTLHVGhGTF...pP...Vc...V-slp-Hc.MHoEahplsp-ssctl..............pt...s...........K.......t.................pG.s............RllAVGT..TSl..RoLE..o....s......upp.........pst...............................................l..p..s..h.p.G..TsIFIhP..G..Ypa+l.VDuLlTNFHLPcSTLlMLVSAF..........u......G.h-.phhsAYcpAlpc.c.......YRFFSaGDAMhI.................................................	0	311	582	740
+4074	PF00788	RA		Ras association (RalGDS/AF-6) domain	SMART	anon	Alignment kindly provided by SMART	Domain	RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure [3] similar to that determined [1], and that of the RasGTP-binding domain of Raf kinase.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.91	0.72	-3.50	54	3464	2012-10-03 10:59:06	2003-04-07 12:59:11	18	281	276	21	1924	3208	3	89.70	17	10.59	CHANGED	spthl+Vahssts.............hpoltlstssospcVlpthlcKhtl.......sssppatL............hhtptstcc..........hLtss-pPlhhhhph..t.........psphhlppppp	............................................t...hl+lah..ts...s.........................hpslt..ls.pp.sTsp-..V.lptl...lp...+h...........tl..............ss......spp.asLh................................hhtt....ts...tc+.........................................hLt..s.p-psl.hhhhph................thphhlcpt..h...........................................	0	459	669	1233
+4075	PF03528	Rabaptin		Rabaptin	Griffiths-Jones SR	anon	PRINTS	Family	\N	27.20	27.20	27.40	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.52	0.72	-4.13	5	248	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	45	2	100	219	0	108.70	41	30.00	CHANGED	KAlAsVSEoTKQEAlscVpRQpQEEVASLQAIlK-Tl.......SuY....EoQasL.LcQE....................RtQhtQspEucERE.lu+L+phLucAp..DsLE+pMKKs+ELs-pL...Kpssp-hEpcI	.....................ph.uth..spcQEth.pshp.pQEEsASL.us...lp.-ul..............suY...........EsQaph.LppE...........................................ptQhtQ.pEutpR.......E....ls.cLpp.hLpcup.....-..sLEcpMc....ctQE.t-hL...+p.s.s.pppI................................................	0	9	16	42
+4076	PF02144	Rad1		Repair protein Rad1/Rec1/Rad17	Mian N, Bateman A	anon	IPR003021	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.72	0.70	-5.63	26	354	2012-10-02 11:47:48	2003-04-07 12:59:11	11	7	284	3	227	571	15	238.90	27	75.42	CHANGED	lFoAsossscpLhslLpslshhs..c..........AhlploscGl+hssE.cs+slQupsalspslFssYpa....................................................................tt.t.ptshssFplsLsslL-sLsIFGssssss..............................................................sCphsYpGpGsPLslhLE-...sslpTpCclsT...............Y-s-........-sh-lshs.csplhhclIh+uchLpsAlpELctstspplplhsos..p.............pP.......................aFtLsop.GphGp......Spl-asscps.....................................lhEpFplp..........pcshps.Ycauhlc+st+AhtlAsKVslRhDppGlLSlQhhh	....................................................................................................................................................h.u.hsssctl.phLpslt.atp...p............uhh.lopp.Glph.s.....s.E.pu..+sl.Q....upsalp.p.p.lFppaph............................................................................................ppttspFtlsLshLl-sLslFusss.st.........................................................................................................................................shphp.Y.t.u...G.tPLhlhlc-........ssls..s..p.s...plpT....................hts-......................tsh-.hs..hp..ps....s.l.h...chlhp..o.phL+cAh..p..............-Lc.s......s.p....lplhhss...p.........................tP........................hh.plps..Gt..hup.......splca...s...psps..........................................h...h....-...tFpsp................ph..s.Y+hshlc..sh.c.....Aht....hu....sK....l.tlRhstpGhLolQhh.......................................................................................................	0	86	129	188
+4077	PF03215	Rad17		Rad17 cell cycle checkpoint protein	Mifsud W	anon	Pfam-B_2764 (release 6.5)	Family	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.80	0.70	-5.82	3	406	2012-10-05 12:31:08	2003-04-07 12:59:11	10	19	278	0	287	3132	1602	329.80	21	56.41	CHANGED	lp-DcsE.WaEKYKPpstc-LAVHK+KIc-VcpWLcApsLEsp.+p...ILLIoGPSGCGKSTslKlLSKELGhplpEWlNPssh+pPsN..QcoDF+GhspspSpF.....hSQhEoFsEF.L+uo+Y.hlQhhGcshpscKKlILlEDLP..NpFatDo.+sF+pVIRpaLpSucsh..PLIhlITEh..-sLEGDNNQR+.....oFsu.pIMsKEILp-PRlosIpFNPIAPTlMKKaLspIlspEhph.tGKsKsPK+pSllEhICQuopGDIRSAINSLQFSuS.....KGppNlR.hKcG......hSLcustVL.pLSKScREu........ps.hshpspp.puhhtKDVoLuhFHAIGKVlasKRuossEl.........DSERIsu.............pLpp.pR-ph.............LVEsEsslp.StLSG-lF+LGLaENYlDFs...hoIDDAsslsDhLShuDsLSGDasos.YsLRElSToFuspGshtpN+upsYh.pphtspphps.aKsQh.......................Fhh.t.hhcpC.uhKtha..FYLPuL.shpot.h.hhshho..M+spstIshlpcI...........GhhPL................cR+a	..........................................................................tt........W.pp.a.........tPts....t-..l....s....l...p........c....K....l.....t.p.l...p.p.h..l....p................t..................h...........t......t................t..t...............................lLllp..GPsGsGKo.s.s....l.p.h....L......u....p....p......h.....s..h..p....l..........c.......h...............s..s................................................................................................................................................p...t......a...........t....h.........................................t..............................................................................................................p.............................p....l..l..L...l..-..-hP.........s.h...t.....t....t..hpt.l.p.h....h..............t....t.....................Pllhhlo...................t........................................lh....s.....p....l.....t......p.....t..ht.........l...pFNslsss.hhKhLphl...ht......p..............................................h..s..........l.p..l...st..............GDlRsAl..tsLph.s.....................................................................................................................................................................+-.sl.hF+u.lG+llaspp.........................................................................................................................................................................................pt.h..........t.....h..hl.hpN...h...................h.p.....h...h..p....hu.sD..h....................................................................................................................................................................................................................................................................................................................................................................................................................................	1	96	159	246
+4078	PF04824	Rad21_Rec8		Conserved region of Rad21 / Rec8 like protein	Kerrison ND	anon	Pfam-B_2686 (release 7.6)	Family	This family represents a conserved region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families.  Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex [1]. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation.  These proteins may also be involved in chromosome condensation.  Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation [2].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.56	0.72	-4.78	16	498	2012-10-01 19:44:35	2003-04-07 12:59:11	11	5	266	4	328	500	17	52.40	30	8.40	CHANGED	ssspt.phspls.supsR+pAA+hFaphLVLpsp..phIplcQ.pcPYu-IhlpssPsh	...............s.......hptls..psss.R+.pAAphFaphL....VLtsp..pslcl.pQ.....p.....ps.....au.cIhhp.t.....................	0	93	164	254
+4079	PF04825	Rad21_Rec8_N		N terminus of Rad21 / Rec8 like protein	Kerrison ND	anon	Pfam-B_2686 (release 7.6)	Family	This family represents a conserved N-terminal region found in eukaryotic  cohesins of the Rad21, Rec8 and Scc1 families.  Members of this family  mediate sister chromatid cohesion during mitosis and meiosis, as part of  the cohesin complex [1]. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation.  These proteins may also be involved in chromosome condensation.  Dissociation at the metaphase to  anaphase transition causes loss of cohesion and chromatid segregation [2].	20.80	20.80	20.80	22.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.44	0.72	-4.11	49	651	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	292	0	433	644	1	112.00	34	17.91	CHANGED	MFaoptlLs+.cGsLuplW.........LAAphpp+.....Ls+pplhpsslsposc..........................................pIhp.............Ppss............huLRlSGpLLhGVVRlYu+KspYLlsDspcsh.+l+hshp.s.........thsh..............ttpsshsslsls	.......................................MFYsp.lLs+..pGPLuplW.........LAAp.hc..+K.......................LsKs....p...lhpssltpos.-...............................................pIlp...........................P.p.s....................hALRh..SGpLLl...........GVVR...........IYs+Ks......cYLLs.Dsscshh..+l+hsa+.s.........s.h-.ls.......t....................................................................	0	128	232	348
+4080	PF03835	Rad4		Rad4 transglutaminase-like domain	Bateman A	anon	Bateman A	Domain	\N	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.92	0.71	-4.79	41	550	2012-10-10 12:56:15	2003-04-07 12:59:11	10	22	265	6	403	698	3	136.50	22	18.13	CHANGED	pslptsphostcpppsp.................tppphtspch.hssaWsEVa...sp................tpc+WlsVDshst...........hhpph-sh...sppspps.hsYVlAass-sss+DVTpRYst.p.hsups++hRls..................tpWa......cpllp......app.pppc..................................DphE-tphp	........................................................................................sp..............................................hs.hhWsEVa.....sp................tpp+WlsV.Dshph........................................sh.pPh..........tpshp.....p...hsYVlAap.s.c...s........ss+DVTpRYsp..p.h..stsc+tRls...........................tpWh.......pp..s.lp............hpp.thpp..................................-phEp.ph..................................................................	0	105	204	338
+4081	PF04098	Rad52_Rad22		Rad52/22 family double-strand break repair protein	Aravind L	anon	Aravind L	Family	The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52 [1]. These proteins contain two helix-hairpin-helix motifs [1].	20.30	20.30	20.30	20.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.98	0.71	-4.49	35	602	2009-01-15 18:05:59	2003-04-07 12:59:11	10	8	410	33	261	527	127	137.00	28	43.84	CHANGED	chpplQspLc+.lss-alotR.GssG.p+........lsYl-uapllsLANElFGFNGWuoplhslpsc................ah-pptt.t...................+hslshsshVRlTLKDGT....a+EshGhGpspshcsKutAapKAKKEAsTDALKRALhs.FGsslGpslYD+phhtp..hsphpps..shch	...........................................................................tt.Lcp.hssE.lp.Rht...tu.u.p+............lsY....l..suctlhphhN-lFGas..GWpsplp.slss............................................................................hshsshsclo.l+...s.so...........................u...ths.....pph....cut..t.....s..........c.......A.hKtuhosuhKR.Ahhp.aG..lGphlYshp.hht..........................................................................................	0	80	143	209
+4082	PF04139	Rad9		Rad9	Wood V, Finn RD	anon	Pfam-B_28077 (release 7.3);	Family	Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage.  It contains a Bcl-2 homology domain 3 (BH3) [2].	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.50	0.70	-5.26	16	382	2012-10-02 11:47:48	2003-04-07 12:59:11	8	8	271	3	251	862	61	232.50	24	56.82	CHANGED	hu+AlpsLSRlGD-LalEsscctLsL+slNSS+SAaushhFss.FFppY.........st.sssshpC+lthKulLslFR......................uhsthptsVE+Cpltl....pspps+.......................................llhplhCKpGlpKTaplsappspsl.pAlaspspssshlphss+lLs-hlsaFspsh-ElTl...........sssp.t+..Vhl+oasE-shct.........p.cshpTplslcs.-EFcpaplstc.................scITFslKEFR...........................uhLtaAEshsssluhaFspsG+Phhho....hs..c.phlEupFlLATl	.........................................tcsl.sLu+h.ucpl.lp..s..............t.....p....t.......LtlpslNso..+SuasphhF.t......FF.ppa.................................tt..ttt...h..p.Cp.l.h..K.u.hh.s..lF+....................................................................................s.t...ppsl-psplpl.................pspps.+..............................................................................l.h.hph.h...s...c......p.G....l...h..K....o.....a.....pl..s.h..............p..................ts......p.....sh..p.................s................hh................s.p...p....t..t...s........s.h.....h.t...hps............+..hLtch.lt..pF..ss.....s...h.....p..-lsl...................................thss..pp.......l.hp....s..at...cp...h...st..............................................p.pshtTphs....l.s....c-....F..p..pa...plttp.............................................hplsF.slK-h+...........................uh...ls...a......u-......s..h..p........h.......s.............ls........hhas.tsGcPhhhs.....hp......p...hpsphllhT.....................................................................................................................	1	84	135	195
+4083	PF04002	RadC	RadC; DUF2466;	RadC-like JAB domain	Kerrison ND, Finn RD, Iyer LM, Zhang D, Aravind L	anon	COG2003	Family	A family of proteins present widely across the bacteria. This family was named initially with reference to the E. coli radC102 mutation which suggested that RadC was involved in repair of DNA lesions [1]. However the relevant mutation has subsequently been shown to be in recG, where radC is in fact an allele of recG [2]. In addition, a personal communication from Claverys, J-P, et al, indicates a total failure of all attempts to characterise a radiation-related function for RadC in Streptococcus pneumoniae, suggesting that it is not involved in repair of DNA lesions, in recombination during transformation, in gene conversion, nor in mismatch repair. Computational analysis, however, provides a possible function. The RadC-like family belong to the JAB superfamily  of metalloproteins [3]. The domain shows fusions to an N-terminal  Helix-hairpin-Helix (HhH) domain in most instances. Other domain combinations include fusions to the anti-restriction module ArdC, the DinG/RAD3-like superfamily II helicases and the DNAG-like primase. In some bacteria, closely related DinG/Rad3- like superfamily II helicases are fused to a 3'-5' exonuclease in the  same position as the RadC-like JAB domain. These conserved domain  associations lead to the hypothesis that the RadC-like JAB domains  might function as a nuclease [3].	20.60	20.60	20.60	20.60	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.13	0.71	-4.43	107	5120	2012-10-10 14:49:21	2003-04-07 12:59:11	10	20	3434	8	980	3486	385	118.30	39	57.04	CHANGED	tlsssp...plhphlp...plt.....stpp....EphhllhLsspspllthpplsp...GolspshVpPRElh+pA.lptsAsulIlsHNHPSGsspPSppDhplT....c+ltpAspllsIpllDHlIl.u.......pspahS.ht-p.Ghl	................................................................h.hposptstcalt.....phs.....s.h.p.p.........EtFhlLaLsspsplIt.tcp.l....Fp....G.Tls...ps.V...a.PR....E....ll...+pA.lp.t.sAuu...l.ILsHNHPS..........Gs..s......p....P..S..psDhtlT....c+lhcAspllsIclLDHlIl..G...........ps.p.hhS.atEcGh.......................	0	330	632	813
+4084	PF04712	Radial_spoke		Radial spokehead-like protein	Mifsud W	anon	Pfam-B_5891 (release 7.5)	Family	This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene [1].	22.70	22.70	22.90	22.70	22.10	22.50	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.60	0.70	-5.75	22	369	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	118	0	235	361	8	295.50	22	75.46	CHANGED	hptplpps...+AaL..ppsspsshsLY-HLsplLs+llc-cPps.uhDl..hEshStpl+pspa............tppcs.ts..phtsshchspppppLFtpst...............................p.p.............tcthscs.lssl...............hpt.shaappuGlGLuc-Esa+lhhAlKpLsc...pcslpssRFWGKIhGhptsYalAEsp..hccsEcptc.tt.t.t.t..ph..t.ttt.................................................lPhEtsts.....GsN+asYaVsspsu.s.sWs+LPsVTPtQIhsuRpI++hFTGcL-AsVho.aPsFs.............GsEtsYLRAQIARISuuTpluPhGh...Y..............phpE-Et.ttppt.tt.p............ph.csP-acslps............ph...phssWVHhhtaILsQGRssah...........tpptE-c...............-E-c-ccc--.cEs............c.EhGssLLsslscD................................................t.tlsst.......ssWoh+hsu.shhs..................paulsVl+SthWPGAashu..s....u++apslYlGaGhKhssp.sasP.....s.PPPstpEass....lsEhpDPos-EEtthch......sp-psp	................................................................................................................................................h............................................................................................................................................................................................................................hht.sGhsls.pc.h...l.hulh.l.p...p....h..tphhFWG+lhGhp..tsYhlsps........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..c...................................................................................................................................................W................................thhhhps.hW.Ghhhh............tt........h..hYhG.G.p.......................................................................h........................................................	0	110	129	177
+4085	PF03089	RAG2		Recombination activating protein 2	Griffiths-Jones SR	anon	Pfam-B_4702 (release 6.5)	Family	V-D-J recombination is the combinatorial process by which the huge range of immunoglobulin and T cell binding specificity  is generated from a limited amount of genetic material.  This  process is synergistically activated by RAG1 and RAG2 in  developing lymphocytes.  Defects in RAG2 in humans are a cause of severe combined immunodeficiency B cell negative and Omenn syndrome.	19.40	19.40	19.40	19.60	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.13	0.70	-5.72	18	5792	2012-10-05 17:30:42	2003-04-07 12:59:11	9	5	4451	0	28	5451	1	268.30	58	91.61	CHANGED	KpsELKLRPloFSNDSCYLPPLRpPAlspl.ssp-u-sppYLIHGG+TPNNELSspLYlhohsS+u.NKKsoLsCpEKELsGDlPcuRYGHTlsVVaSRGKohsVlFGGRSYhPsGQRTTEsWNSVVDC.PpVFLlDLEFGCCTSahLPELpDGhSFHVSlARsDsVYlLGGHoLpossRPPpLa+LKVDL.LGSPsloCTlLsuGlSlSSAIVTQsus..cEFlIlGGYpS-sQKRh.CNolsL-DssIcIppREsP-WTu-IKHSKTWFGusMGpGuVLlGIPu-sKptssDup.aFYhlsFtp-c-t.....stQsCSQEST.pD.EDSsPLEDSEEFYFupE	.........................................................ts.....pYlIHGG+TPNNElSsplYlhohss+s..N+KlThpCpEK-LVG-lPtARYGHolsVVaSRGKohsVlFGGRSYhPsupRTTEpWNSVlDC.PpVFLlDhEFGCsouahLPELpDG.SFHlulARpDslYhLGGHSLssssRPPpLaRl+V-L.LGSPsl..oCsl.L.ssGlSlSSAIl.Tps.....u.....s........cEal.IlGGYpSDsQKRM.CshlsL--stIchp.hEsPcW..TsDIpHS+hWFGushGpGshLlulPstsp....s-s..ahY.lpht......t.............................................................	1	2	4	11
+4086	PF04901	RAMP		Receptor activity modifying family 	Finn RD	anon	Pfam-B_5615 (release 7.6)	Family	The calcitonin-receptor-like receptor can function as either a calcitonin-gene-related peptide or an adrenomedullin receptor. The receptors function is modified by receptor-activity-modifying  protein or RAMP. RAMPs are single-transmembrane-domain proteins [1]. 	20.40	20.40	20.70	21.50	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.45	0.71	-4.33	19	191	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	42	22	86	148	0	108.10	39	71.27	CHANGED	tthtphChppFpccMcsls.phWCsWsphhp.YppLosCTchhAchlsCaWPNshs-cFhhtlHppaFpNColsththpDPPsslLhshIllPIhlTlhhsuLVVWRSKco-uhs	............................hh...phChptFptpMppls..ptWCsWs.ph....h...t..YppLopCTchhAptlsCaWPN..shs-pFh.htl.HppaFpNCs...l.s.th.thpDPPsslLhshIllPlhlThhh.suLVVW+SKcs-s.h......................	1	9	17	37
+4087	PF00638	Ran_BP1		RanBP1 domain	Bateman A	anon	Prosite	Family	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.41	0.71	-4.07	8	1512	2012-10-04 00:02:25	2003-04-07 12:59:11	13	83	333	19	988	1495	10	115.30	30	23.31	CHANGED	EVKoGEEDEEsLFppRAKLaRFDs-s..ppWKERGlG-lKILKpKcs.sKlRlLMRRDplLKlCANHhIossMpL.KPhsGS-RualWts.uDaADu-uKsEpLAlRFKspEsA-pFKppFEEuppt	......................................ltTGE.E..s..E.c.slap.h.+.uK..L.a..ca..............s.....p....ps...............pp..W.....K....ERGhGsl.+..l......L.............c.............p......p.........p......s.....t.........p..........s.........R.llM..R.p-..........p.s.....h.............+...lh..hNphl...hs...s...h.pl....p......t.........ss..p...................c...u.hh.a........ts......hD......h..u...-..t...p....s...c...................s..............pp..h..sl+h....ts....t.-......Apphtphhpch.................................................................	0	331	490	762
+4088	PF03085	RAP-1		Rhoptry-associated protein 1 (RAP-1)	Mifsud W	anon	Pfam-B_1750 (release 6.4)	Family	Members of this family are found in Babesia species. Though not in this Pfam family, rhoptry-associated proteins are also found in Plasmodium falciparum. Indeed, animal infection with Babesia may produce a pattern similar to human malaria [4]. Rhoptry organelles form part of the apical complex in apicomplexan parasites. Rhoptry-associated proteins are antigenic, and generate partially protective immune responses in infected mammals. Thus RAPs are among the targeted vaccine antigens for babesial (and malarial) parasites. However, RAP-1 proteins are encoded by by a multigene family; thus RAP-1 proteins are polymorphic, with  B and T cell epitopes that are conserved among strains, but not across species [1,2,5]. Antibodies to Babesia RAP-1 may also be helpful in the  serological detection of Babesia infections [3].	25.00	25.00	55.30	48.50	22.00	18.70	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.76	0.70	-5.03	12	102	2009-09-11 11:32:32	2003-04-07 12:59:11	10	3	9	0	17	101	0	195.70	39	57.46	CHANGED	scoLtssspshpsttpppchspsMpp.hs.hssphh-tlCptshcp.spC+ptVssYVsRCpptsCholDshpashptp.psLsLPsPYQL-AAFhlF+pssusPh+pthcphhhRF+psupausY+pFlhsLLp+N...hhhcssssD..l-shls+YhYMsTlYYKTYLsl-phpu+hhN+hsFs+alFuhtI++ALppIl+sNlPccht.chslsclpplssuYtpYhh.sQlPshspFApcFupMVhcsLlpolu	....................................................hpttMt..h...tp...tphCpts.tt.ppCtt.ltsYhpRCtt..hsChTlDshph....t.psLsLPs.aQL-AAFhLF+pSsuN.t+pthcp.hh..........Rh+t...ttpasta+pFlhsLhppN...hhp.p.tssD..l-.thsspahYMsTlaY.KTYL...sls.hsAKhhN+huaopclFuh.tIppsLppll+.NlP.sht.phs.tplpplssuYtpYhh.oQlPshspFAccauphshcsLl.sls................................................................................	0	2	10	10
+4089	PF00071	Ras	ras; 	Ras family	Sonnhammer ELL, Fenech M	anon	Swissprot	Domain	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head.  See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.79	0.71	-4.85	61	21243	2012-10-05 12:31:08	2003-04-07 12:59:11	17	332	1006	663	12839	30754	3385	151.90	29	62.64	CHANGED	KllllGDuGVGKSsLllpFspspFsppa.sTIth-.....Fhp+plplD..........ucplcLpIWDTAGQEcacslpstYYRsupGhllVYslTscpSFpplp.pWhp-lpchss..........pslshlLVGNKsDLcp.................................pRtVstpcupphA.......cchs.lhFhETSAKsshNVccsFhpls+plhp	.........................................................................KllllG.c.u........u.V.G...K........o....s........L............l...............h...........p.............a..............s.................p..............s...............p..........F..............s...........p............p........h.........................s........T.........l..................h..-..........................h..h...t....p......p...l...p....l..s.......................................s.p..p...l....p..L........p....l.........W................D.............T.........A..................G............Q............E.............c..........a.............p............s..........l...........p..............s...........h................a...........a.................+...............s................u..............p.....u....h.......l.......l.......l.........a....s................l....................o...........s............p.........p..............S..........F..........p.......s............l.............p......p..........W...h...p....c...l.p..p....h.ss...............................ts.h...s..h..l.L....l.......G...N.....K....s......D....L...p.p......................................................................................................................p.+.......V...s.....t......p.....p.....u.....p.....t....h..A.....................c...p...h.......s.....h...............a........h...........E.....s...S...A..p...s.........s..........s.....l...c...p....s...F..phhpth..t.....................................................................................................................................	0	4857	6747	9773
+4090	PF00616	RasGAP		GTPase-activator protein for Ras-like GTPase	Ponting C, Schultz J, Bork P	anon	SMART	Family	All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.30	0.71	-4.65	115	1769	2012-10-03 21:54:49	2003-04-07 12:59:11	14	106	254	6	1114	1705	9	183.90	26	14.50	CHANGED	hlppllp...pEl........................pp.ssp...sslh.R..uNohso+.hlspah+t.....hGppYLcpsLtsh....lpcl.h..ppchsh..ElDPtcl.................................................................................................................................................sppphp........pshppL...tphspphhssIhs.Sh.sp....h.Phsl+hlsppltpplpp+a...t.................................pth..hpsluuFlFLR..FhsP..AI......ls.Pchaslh....p....ts.stptpRsLhhluKll.QslAs	.............................................................................................................................................................................................hpphhp....tEl.............................pp...ssp...pplh..R.uN.ohso+.hhppah+h...........hGppYLpps.L..tsh.......................lppl.h........cpch....sh.El.D.Ps+l................................................................................................................................................................................................................................................................................ppplp......................psh.ppL...hthspphhssIhs..Sh..sp......h.Ph....tlRhlhpp.....lpptspp+.a.t...................................................................................p.h......hphluuhl.FLR..FlsP.AI............ls..Pchaslh......p....................p..sspspRsLs...hlAKhlQslAs................................................................................................................	0	379	541	819
+4091	PF03836	RasGAP_C		RasGAP C-terminus	Griffiths-Jones SR	anon	PRODOM	Family	\N	22.10	22.10	22.50	22.50	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.45	0.71	-4.50	38	469	2009-01-15 18:05:59	2003-04-07 12:59:11	10	30	217	6	318	442	1	133.50	33	10.26	CHANGED	shtchKpcslcslpcLEphGhlspp.NpYQp......llspIAp-I+sppphRppcppElctlppohpsLpc+spaLppQlcpYpsYlcsshtslptptp...................tpthhth+php+p.s+t.chGsaKaoAppLtccGVllchp..s.ptp	..............................htcpKp+hhcsLp.pLE..phGh.....lspp.spYQp......lls-IApDI+spcphR..ppRptELtpLppThpsLscKssahppQlchYcsYIcsshs....sLppptt..........................h.t.pthpcp.s.+tp+hsshKYoAtpLp-K.GVLlchpshp..t........................	0	97	155	240
+4092	PF00617	RasGEF		RasGEF domain	Ponting C, Schultz J, Bork P	anon	SMART	Family	Guanine nucleotide exchange factor for Ras-like small GTPases.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.16	0.71	-4.57	148	3434	2009-09-12 23:24:09	2003-04-07 12:59:11	14	184	292	23	1986	3165	4	186.00	25	19.95	CHANGED	hshsst-lAcQLTll-h...cl....app....Ip.....................pE..............................hl..spta.......sp...pp.............................ss.s......lpthlpphNplopaVsspIltp.p.............shccRspllp+aIclA...........p....................p.hcplpNasohhAI.luuLssssltRLcpTWptlspcth...c............h.hpcLppl............h............................ssp..................pNapsY..R.....ptlp...................................ps.....Ps.....................lPalGlaLp..........................DLsalpcu...ss...................shlps............................................llNFpKh..pp	........................................................................h..hsshclApQLThh-h...pl......Fpp....lp..................................................pE..............................hl..t.t.h.a......pp.............pp...t.......................................................................ss.s.........l.pthlppa.Nplo.....h.a...Vs..spIltp..t.....................shppRs.p.l.lp+.a.IclA..p..........................................c..h.p..p...lp..NasohhAI.l..uuLs..s...s..s..l...t.....R.L........c....p.T....Wp..........p.......l.spc.p........p.....................h..hp....pLp..p.l.....................h..................................................................ss.p..................pN..ap...ph....R.......phlp..................................................................phps....ss..............................lP.a......h..........u.........l.h.Lp..........................Dlhhlcpu....s.................sh.h.tt....................................................................................hlNapKh...................................................................................................................	1	658	907	1382
+4093	PF00618	RasGEF_N	RasGEFN; 	RasGEF N-terminal motif	Ponting C, Schultz J, Bork P	anon	SMART	Domain	A subset of guanine nucleotide exchange factor for Ras-like small  GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.	28.30	28.30	28.30	28.30	28.20	28.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.50	0.72	-3.92	88	2431	2012-10-02 12:00:53	2003-04-07 12:59:11	15	132	260	14	1433	2250	2	105.10	21	10.42	CHANGED	plpuuolp..tLl-tLssp.ph........c..sahpsFlhoa+sFs.ostclhphLhpRa............................h.ssstph.ptt..............................................................hph..+...lhpllppWlppaht...-......apps...............hlpplhpa	............................................ltuuoh-cLlp+Ls.pp...phh...........................-s.salp.sFLhTaR.....sFh.o.s..........pc.Llpt.L..l.p..pa.............................................................................................................................tstt..ptt...........................................................................................................................................................................................hph....+...lhpllp.tWlppa.....-...........Fpts.........hht.h...............................................................................................................................................................	0	411	620	975
+4094	PF01858	RB_A		Retinoblastoma-associated protein A domain	Bateman A	anon	Swiss-Prot	Domain	This domain has the cyclin fold [1] as predicted [2].	25.00	25.00	25.50	26.70	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.50	0.71	-4.64	7	366	2012-10-03 00:42:12	2003-04-07 12:59:11	12	10	157	16	185	368	1	188.10	38	21.11	CHANGED	TPVpoAhsolppLpshlsuh.spPSppLpphhpsCsps.ppslhcRlptlhEhhhpphs.u.ct...........s.phAppRhphA.pLYY+VLEshhpuEtcpLss.shosLLspch....FHcoLlACslElVhtoYps.........s.hpFPalLEshslpsF-F.KVIEsFIRp...EssLsREhlKHLNSlEEplLESLAWppsSsla-hl	..........................................TPV.ssAhpolppLps.hlsu..h..ts.tP.S..ppL.ph..hp.s.Csps.......P...pp...s...l.h..........pRlcplhchappp.hs.....t.s.sttt.................................shphu.ppR...hphAt.tL...YY+lLE..sllppEp.c..................R....L...s.....s..t...................s....h.otLL....p.p.-h....FHpSLlACsLElVhhoYps.....................s.hsFPall-lh.slss....Fc....F...aKVIEsFI.Rs..............Ess..L.sR...-hlKHLsplEEplLESlAWppsSsLaphl............	0	49	77	127
+4095	PF01857	RB_B		Retinoblastoma-associated protein B domain	Bateman A, Griffiths-Jones SR	anon	Swiss-Prot	Domain	The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain [1].  The B domain has a cyclin fold. 	20.70	20.70	22.20	21.10	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.86	0.71	-4.66	6	352	2012-10-03 00:42:12	2003-04-07 12:59:11	15	10	158	15	185	360	5	140.60	39	15.49	CHANGED	soLslFa+KVY+LAulRlpsLCp+L.s..........lp-cLccpIWshFcaoLspps-LMhDRHLDQllhCAhYshAKVsp..-hoFp-IhpsYRsQPQApspVaRSVhIct.........p...p............................h..pchsDIIsFYNplalsplKs	...............................................oLslFa+K.l...Y+LAulRLps....LCt.+L.s.............................ls.s.-..lc..cpI.WT.hFcao.L..p.p.s..-L.MhDRHLDQllhCuhYshs.K....Vs..p..............-.h.oFppIhpsY.R...p..Q....P.Qu............psp.V...a.RsVLlcp.........................................................................................pchsDlIpFYNplal.plK............................................	0	53	81	127
+4096	PF02196	RBD		Raf-like Ras-binding domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	25.70	25.70	25.70	25.90	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.09	0.72	-4.22	10	710	2012-10-03 10:59:06	2003-04-07 12:59:11	10	34	96	14	293	599	0	70.50	30	9.82	CHANGED	phhpVaLPssQpolVtVRsGhol+DsLppslcpRGLssssstVhhht......t+csLshcsctuhLsu.cElhlEhh	....................hhplhLPspppsll.ssRs...Ghol...c-sLpthlcp+G....Ls.p..sssVahht.......pccslshspsh..s...Lsu.c-lhlEhh.....................	0	45	68	156
+4097	PF02033	RBFA		Ribosome-binding factor A	Mian N, Bateman A	anon	IPR000238	Family	\N	25.00	25.00	26.10	25.40	24.90	23.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.07	0.72	-4.00	183	4543	2009-09-13 23:02:53	2003-04-07 12:59:11	13	5	4463	8	1061	2620	2217	105.00	34	77.59	CHANGED	RspRlu...pplp+plupllp..pp.l+..DPRl.........shlolocVclSsDLphAcVal...ol....h........................sp....................ppt..cpshpsLppAsGalRpplucplp..lRhsPcLpFhhD...p....ol-put+lspLl	..........................RspRlupplp+Elupllp....cc..l+........DPRl..............thlTl..ocVclosDLphA+Val...oh..l..s.......................sp...................ppt...cpsh.puLp.c.Ap..GhlRppLG+p.lc..LRhsP-LpFhh..Dp.Slchut+lspLl.........................	0	369	692	897
+4098	PF05025	RbsD_FucU		RbsD / FucU transport protein family	Moxon SJ, Bateman A	anon	Pfam-B_4828 (release 7.6)	Family	The Escherichia coli high-affinity ribose-transport system consists of six proteins encoded by the rbs operon (rbsD, rbsA, rbsC, rbsB, rbsK and rbsR). Of the six components, RbsD is the only one whose function is unknown although it is thought that it somehow plays a critical role in  PtsG-mediated ribose transport [1]. This family also includes FucU a protein from the fucose biosynthesis operon that is presumably also involved in fucose transport by similarity to RbsD.	25.00	25.00	27.90	30.40	24.60	23.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.74	0.71	-3.87	133	2765	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	2076	86	395	1291	399	134.10	35	98.06	CHANGED	MpcsslLNs-L.pllAshGHsDpllIuDAshPh....s.tspplcLslphsssshhplLcslLsph.l-phlhupphthp....ss...thhsslhpth.........ttsh.lphls+ppF.hcp.s+p..upAllpTGEpssYuNlILpsGVlh	........h+hsslLss-l.plluchGHsDpl.......ll...sDAs........hPh..........s.ts.ttlclslpt.sssshhplLpsllsphpl-s..hh....hA.pphhtp........ss...ph.ht.plhpchtt..............t.tssshpIphl.sH...p...pF.ccp.spc.......upAll.RTGEsosYu.NIILpsGVs......................	0	101	207	293
+4099	PF02341	RcbX		RbcX protein	Bashton M, Bateman A	anon	Pfam-B_948 (release 5.2)	Family	The RBCX protein has been identified as having a possible  chaperone-like function [1].  The rbcX gene is juxtaposed to and cotranscribed with rbcL and rbcS encoding RuBisCO in Anabaena sp. CA [2]. RbcX has been shown to possess a chaperone-like  function assisting correct folding of RuBisCO in E. coli expression  studies and is needed for RuBisCO to reach its maximal activity [2].	21.00	21.00	22.40	21.70	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.37	0.72	-3.93	16	676	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	573	77	69	329	10	109.20	67	78.97	CHANGED	M-lKpIAKDTAKsLtSYLTYQAVRsVhsQLuETNPshAlWLppFSuptpIQDGEuYLctLhpEsp-LuhRIMTVREHLAc-VsDaLPEMVRsuIQQuNhEHRRQhLERlTQ	.........................................MsLKQIAKDTAKTLQSYLTYQALRTVLAQ.LG........ET........N......P.P....L..u..hW.....LpNFSu..GKI.Q.DG.EuYIEpLhtE...K....s....D.L...ALRI..MTV.REHI.A.p....E.l....s..E.F..LP..EMVpTGIQQANMEQRRQHLERITp...............................................	0	18	48	64
+4100	PF00415	RCC1		Regulator of chromosome condensation (RCC1) repeat	Finn RD	anon	Prosite	Repeat	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.40	0.72	-3.75	104	14888	2012-10-05 17:30:42	2003-04-07 12:59:11	13	606	566	106	9774	17535	3239	51.30	29	20.18	CHANGED	cGplasWG..psptGQLG..............tssppspthPph..lphhps..............lhplu.sGspHohsl	......................GplasW......G............ps....s..........h.....G.Q.....LG.....................................................tss...p..p...s...p...h....t..P..ph.........l..p...s..hps.................................tlh..p..lu...s..G..s...t.Hohsl.......................................................	0	3249	5152	7453
+4101	PF04381	RdgC		Putative exonuclease, RdgC	Kerrison ND	anon	COG2960	Family	Members of the RdgC family may have exonuclease activity. RdgC is required for efficient pilin variation in Neisseria gonorrhoeae, suggesting that it may be involved in recombination reactions [1]. In Escherichia coli, RdgC is required for growth in recombination-deficient exonuclease-depleted strains.  Under these conditions, RdgC may act as an exonuclease to remove collapsed replication forks, in the absence of the normal repair mechanisms [2].	25.00	25.00	28.60	28.30	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.78	0.70	-5.46	71	1392	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	1234	4	260	909	119	288.20	47	96.62	CHANGED	MW..FKNLhlYRhscshshss-pL-cpLsptsFpPCuup-hpphGWlsPhucpsp..LsHssssplLlsh++E-KlLPuuVl+ctlcc+lpplEtcpuR+lt+KE+cpLK--lhppLLPRAFo+pppThuaIDsppshllVDuuSsp+AE-lluhLR+o.lG.SLPls..PlpsppsPsssMTpWLtps.psPssapls-EsEL+us.t-cuuhlRsKpp-Lpu-...EIpsHlpuG.KhVo+LALsWp-+lsFlLs.....--hslKRlKFtDhlpEps--h.sp-Dhst+hDADFsLMosELsphlspLlpshGGppp	...............................................hWFKNLhlYRL..s+-ls......h.....p.u.-p...hEcpLuphsFoPC...G..S.Q.D..h.s+.hGWV...s...P..hG...p..p....u.-h....L....s....H...su....s.s..pll..lsA+..KEEKlLPusVIK..pt....Lc....t.Kl....t.c....l.E....s...-..p...u.R.K.L...+KpEK-sLKD-Vlc...sLLPRAFS+hopThhaIDsssGLIhVDs.ASuK+AEDsLALLRKo..LG....SLPVV.......PLs...h...cs...s....p......hsLT-WlcsG..sss...p....G.....FpL..h-E...AELKuh...hE-.G.ulI.RsK+.QD.Ls..u-...E.ItsHI-.AG.KlVTKLAL...s..W....p......p...RlpFVhs.....-DholKRLKFsD.pL+-QN..-Dl..scED.hApRFDADFhLMouELusLlpsLl-uLGGEt.p.........................................	0	53	130	207
+4102	PF05183	RdRP		RNA dependent RNA polymerase	Wood V, Bateman A	anon	Pfam-B_2226 (release 7.7)	Family	This family of proteins are eukaryotic RNA dependent RNA polymerases. These proteins are involved in post transcriptional gene silencing where they are thought to amplify dsRNA templates.	20.80	20.80	21.00	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	580	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-13.05	0.70	-5.82	94	667	2009-01-15 18:05:59	2003-04-07 12:59:11	7	26	187	3	486	719	5	486.90	23	46.88	CHANGED	splhhpssphphss+lhRc.................a.t.pp.....Flclpas-cphpthh.t...........................hpphtphhtpulhl..........s.htapa..hs.stpt...............h+ppssahhsss.........................hshpphhphh.sshpp................sKhhuR.....hu.shosohs........lphpph.............phlsDl........................................................ttpth..........shoDGs...GhlS.slsctl...tppls.............................................................................htthPoshQ..hRh..................sG.sKGllh.l....s.ph.........................hlhlRt.ShhKa.................psthpsl.....................-lhphup..................p.shLN....................cphlhlLpphGl....pc.........hFhph.pptlpphtp..hhts....pthhphhpphtp.s.hth................................................................hhttuh..........tppsalpphlpthhppplpphpp.....+h+I.lsputhh..hGlhD.t.................Gh.....Lc..........sclalt.............................................tsttp.phlpG..pllls......RsPshpPuDlph..lcA.............lth....st............Lpp.h....pslllFss....pGt.................................pshss.huG..uDh.DGDtah...lh.......WD.pl............hs.tshp................................hphpphtcahhp.....hpsshlGhhsstahths..........................shhsspshpLuphhutslDhsK.sGh.hp.....h.p..................ht.pthPcahp.......................pptt.....................sppllsplacphtptttttttp	.........................................................................................................................................................................h.s..ht.ssphhRp...a.t.tp......hlclp.h.ptt...h......................................................................hhpphhthhtp.uh.h...........stphap..a..hs.stst.........................................h+ppt.s..ahhs...............................................................hph.t.thhphh..sphpp..........................sKhhuR........hu.shSpoh..........lt.pph..................h.Dl........................................................................................tttth......................haoDGh...GhlS.thsptl..hptht.............................................................ht..PoshQ..hRh.......................sG.hKGhlh..l.....................s.p...................t..........................l.lR...S..Ka....................................ttptttl...................................................................................-lh..p..hup....................shLN...........................pphl..lLpp..hu.l........pp............hh.ph.pp..lpphtt....hh.s.............ttshphhpt....t...t................................................................................................hh..Gh............ppsalpthl.phhht.tl...............tth..pt.......+h+I...ls..p..uhhh...hGshD.h......................sh.....Lp............................splalph..............................................tttt..h.ltG.......llls......+sPshhPGDlph..h.pA.........................................................V.h..........st..................Lpp..h....hsslVFsp....pGt...............................................................+shss..huG..uDlDGD.ah..lh.........WD.pl......................h......shp...........................................................t.pph.pahhp....................h.ps.lGhhsph+..hhs................p..........th.s..shpLuphhu......sV..DhsK..oGh.sp....h.t........................h.Pcaht..................................t...........................................utplls.lh..h.........t.....................................................................................................................................................................................................................................................................................................................................................................................................................................	0	210	321	430
+4103	PF00154	RecA	recA; 	recA bacterial DNA recombination protein	Sonnhammer ELL	anon	Prosite	Family	RecA is a DNA-dependent ATPase and functions in DNA repair systems.  RecA protein catalyses an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.95	0.70	-5.37	28	12149	2012-10-05 12:31:08	2003-04-07 12:59:11	16	16	9034	84	1090	10099	5077	240.80	66	92.66	CHANGED	KALssALuQIEKpFGKGolM+LG-cs.t.cl-slSTGSLuLDlALGlGGlP+GRIlEIYGPESSGKTTLsLHsIAEsQKpGGssAFIDAEHALDPtYApKLGVclDsLLlSQPDsGEQALEIsDtLVRSGAVDllVVDSVAALsPKAEIEGEMGDuHVGLQARLMSQALRKLTGsls+SNThlIFINQIR.KIGVM.FG.sPETTTGGsALKFYASVRLDIRRhuslKcus....chlGscT+VKVVKNKVAPPF+pAEFDIhYGEGIS+hGEllDLGVchsllcKSGAWYSYpsc+IGQG+ENA+paL+-sP-lusEIEpplRpphsh	...................................................................................................................................s.lM..+.h..G..p.t..t.......pl.p.s.......l.uTG.SL.......uLDl..A.L.......G...........l.........GGLP+.G....Rl..lEI.Y.....G.P.E.S..S.GK.T....T..L....s....L.p..s...I....A......p............u......Q...........K................p..........G....G........h................s...A...F..I....DA......E........H.....A........L..........D............P........h.........Y......A.........c..........K....L..........G........V.............s............l.........D..........s...................L..........L.........l...S.......Q.........P...........D...........T............G.......E....Q.......A..........L.......E....I........s.........D.......s....L........V.....R.......S.....G..A.........l......D........l....l.VlD.SV.AA..L..s....P..K...A..........E.....I..E....G..E..MG..D...........S.p.s......G...L..Q..A...R..LM..S..QA..LR.....KLTu....slp.pos.s.....h.s....I.FINQl.R.........K....l......G......V...M....F.....G....s...P...E..T..T..s..GGpALKFYuo..lRh...-......lR.......p........t......t........lK...t.tt............t.h.G.ps+h+lhKs+hs....................................................................................................................................................................................................................................................................................................................................................................................	1	379	738	938
+4104	PF02565	RecO_C	RecO;	Recombination protein O C terminal	Mian N, Bateman A	anon	COGs	Family	Recombination protein O (RecO) is involved in DNA repair and Pfam:PF00470 pathway recombination.	20.50	20.50	20.70	20.50	20.40	20.40	hmmbuild  -o /dev/null --hand HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.54	0.71	-4.24	157	3973	2009-01-15 18:05:59	2003-04-07 12:59:11	10	9	3952	7	846	2634	1633	151.60	18	61.19	CHANGED	ht-htthshutalsELlpthl..-pcsp.sp..LaphhhtsLp.tL.....spps......s....hhhhh.FElpLLphhGas.slspCstsGpp.s.shh..h......................ttpsspsttshths.pshtllthhhpt...t...ht...hsspshp...pht......plhptalppplst.thpspp	............................shhthhhuhalsELls+hl....t....c....p.....pst...st.........LFphhhpsLp.tL..............spsp............ss...thhthh.FElplLst.hG.ausshscCstsupssstthh.hh....................................................................................................................t.ppttpsttththsspshhlhphhtth..thpt.......ht........t..h.s.t.p.p..hp.........php.................phhphhh...c.a.lst...L+Sh.....................................................................................	0	279	551	713
+4105	PF02132	RecR		RecR protein	Mian N, Bateman A	anon	IPR000093	Family	\N	29.10	29.10	29.50	29.40	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.20	0.72	-4.52	192	4246	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	4214	6	904	2429	1218	41.00	38	20.52	CHANGED	p.tsppLApAltpstpplphCphCtslo-..p-....hCsICssspR.D	...............ts.cLApALhpApcclpaCshCtslT-..p-........sCpICs-spRD....	0	309	605	770
+4106	PF03837	RecT		RecT family	Aravind L	anon	Aravind L	Family	The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to RecT [1].	20.80	20.80	21.00	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.19	0.71	-5.02	81	1551	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1057	0	145	1046	127	180.60	24	65.71	CHANGED	sphhptshshlpp..........................pL...tt......ssspshhsslhpssphsLsPht....ppsYllsa.....................hs.tcsphhhuhcGhhplApRssphp..ulputslhctc.hphpht...........ht........ppsphlusaAhhhh.....psstp.h..hhhshpphppttp................p.ttt.........................s.W..tsp.cpMhcKsslpphhp+hhPhshp.............shhstDEh...............t.pppppsss	..........................................s....p.hhthlpp..........................th.....hp.......ssstphhshlh...ssphG..LsPhs....ppsYhl..P.................................ht.sth.phh.luhcG..h.plh....p..cstp..hc..........uhp.hp.s.hc....ht.t.........................................................t..hushshlhh.....pstsc..h...p.hhhc..phcp.hp.......................ptptt......................................usW..ps..p.......c....pMh.++pshhphh.+hhhshu.....................shhstDEt......pp.........t.ts................................................	0	44	96	119
+4107	PF03838	RecU		Recombination protein U	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Domain	\N	25.00	25.00	26.10	25.80	23.70	23.10	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.98	0.71	-4.73	43	1337	2012-10-11 20:44:43	2003-04-07 12:59:11	9	3	1214	10	140	682	9	163.20	48	83.68	CHANGED	NRGMoLEctINpoNpYYLspslAVIHKKPTPlQIV+VDYPpRStAsIpEAYF+psSTTDYNGVY+G+YlDFEAKET+NKouFPLcNhHpHQlpHhcplhpQsGIsFlllcFsshcchallsuppLhpaWpt..pssG+KSIPhs.I.....pcpuaplphshpPplsYLcsl-pl	.......................................pRGMohEc.INpoNpYYLppslAVIHKK.PTPlQIVcVDYPp.....RSpAhIsEA.YF.+psSTTDYsG...VY..p.G.h.Y.IDFEAKET+s.Ks.uFPh.....p.....NhHtHQIcHMcpshp.QpG..I..sFll.l+Fso..hpE.sYlLPsp...clhpaa.....psp.........G+KShsls.I.....cc.pGapI.phsh.t...Ppl.sYLcsl-p..............................................	0	47	90	115
+4108	PF02631	RecX		RecX family	Mian N, Bateman A	anon	COG2137	Family	RecX is a putative bacterial regulatory protein [1]. The gene  encoding RecX is found downstream of recA, and is thought to interact with the RecA protein.   	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.60	0.71	-3.91	147	4223	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	3600	6	808	2825	1656	117.80	22	66.09	CHANGED	Lpp+....h.sp.ch....lcpllscLpchsal.sDpcaActalcs+ht.pshGstplppcLp.pKGlsppllp.psLp....p..hs.tpp.......................Atplhp++hpph.....t....................hctcpKhhpaLhp+GFshchlpp...slp........ttt-	............................................h..st.p......hppllshhtc.thl.sDtcautthlpsp...t..ps.h...G...ttl.p.pcLt.p.K.G..ls......p....p..h..lc....ps.lp...........c..hc.pc..................................Apcl.hpKch.pph......ht.ss...............................................................hphcpKlhphLhp+Gash-.Ippslp........t.tp...................................	0	262	516	680
+4109	PF02014	Reeler		Reeler domain	Bateman A	anon	Bateman A	Family	\N	21.00	21.00	21.00	21.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.95	0.71	-3.90	40	496	2009-01-15 18:05:59	2003-04-07 12:59:11	11	45	110	8	357	521	42	122.60	24	18.03	CHANGED	sCschh...PpH......stsPp....sssaplsss..spsatsGpphpVsl....tt.ssspF.cGFhLpARssss.tt..........................lGpFsls.sss.hpphhsC.....sAVTH...ssspsKpplpl.hWsAPss.s.GslhFpATllpphtlaasc	.................................C.th.......tt..........ttp.t...sssap...ltss.........sptahsGpphpVol...................sst.F..cGFhlpAcptsspt...........................lGpFphh.ssp..........h..p.......h..hhsC.........................su..loH...sssp......tK..s..p.l.p..l.hWtAPs................ss....s...G...sV.hFpAT.ll.ppht.haah...........................	0	151	183	286
+4110	PF04221	RelB	DUF415; 	RelB antitoxin	Mifsud W	anon	COG3077	Family	RelE and RelB form a toxin-antitoxin system. RelE represses translation, probably through binding ribosomes ([1], [2]). RelB stably binds RelE, presumably deactivating it.	20.90	20.90	21.00	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.44	0.72	-4.23	6	2614	2012-10-02 18:44:02	2003-04-07 12:59:11	7	4	1541	3	352	1624	75	79.40	22	87.15	CHANGED	suhlshRID-clKspAssVLcpMGLThSpAl+lhLsplApsculPF-lplPpsNptTlsuIpctctGps.......ppshsscchhscl	.............lphRlDpclKppApplhpphGlshosAlplhlpplspp..pu..lP..F....c.l....p.......h......s..................s.......p..ts.h....t.s.h.......p.....c.............................................................................	0	120	212	267
+4111	PF03763	Remorin_C		Remorin, C-terminal region 	Farmer EE, Finn RD	anon	Pfam-B_1798 (release 7.0)	Family	Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible.	22.10	22.10	23.80	23.60	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.77	0.71	-4.54	28	381	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	26	0	224	354	0	105.30	33	31.49	CHANGED	pccp..puhhsAW-EuEcuKhps+hp+cpscIsuWENpcKAKsEApl+KlEpc.LE+KKActtEKhpN+lAtl++cAEE+RAts......EA+Rscchh+scEtAs+h..RsTG+hPsphh	......................t..pthtshhsAW-c.u.EpuKhps+...hc.......+........c.cspIpuWEsppK....AKsEAph+.KhE..........t...c.lE+c+AcshEKhts+lAt.s++pAEEp....RAts......EAc+spchh+st-.tAshh....R.tsGphPtp..................	0	36	136	183
+4112	PF03766	Remorin_N		Remorin, N-terminal region 	Farmer EE, Finn RD	anon	Pfam-B_1798 (release 7.0)	Family	Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich C-half and a more conserved N-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the protein is alpha-helical. Remorins exist in plasma membrane preparations as oligomeric structures and form filaments in vitro. The proteins can bind polyanions including the extracellular matrix component oligogalacturonic acid (OGA). In vitro, remorin in plasma membrane preparations is phosphorylated (principally on threonine residues) in the presence of OGA and thus co-purifies with a protein kinases(s). The biological functions of remorins are unknown but roles as components of the membrane/cytoskeleton are possible. 	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.84	0.72	-4.19	5	55	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	19	0	34	55	0	59.00	43	30.80	CHANGED	ssVscEpApscsssPPPs..cpKsDDSKALsVVEsssEEsAscKsucGSlDRDVlLA+L	.......................ssc-hA.pEK...ss.sP...PPs.......cpc....s....DDSKALs.lVE...K.....ss.E.s.....stc....K..ss....p....GSl-RDssLA+l.	1	5	22	28
+4113	PF01244	Peptidase_M19	Renal_dipeptase; 	Membrane dipeptidase (Peptidase family M19)	Finn RD, Bateman A	anon	Prosite	Family	\N	20.20	20.20	20.40	20.20	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.68	0.70	-5.50	48	2249	2012-10-03 00:45:34	2003-04-07 12:59:11	16	15	1559	27	897	2181	2191	312.60	26	85.48	CHANGED	th.tph.llDuHsDhshphhtt.t.................t.t.hchsl.+h+pGtlsuthhula.h...........................thppuhptsLcplshhpphhpppsp.lplspossDlcpshp.cs+luhlhuhEGucsl..sscl...shLctaapLGlRhlsLTa.stsN.hucushpt........pssGLoshGcclVpchNcLGlllDlSHhucpshhDsl.......plSctPllhSHSsu+ulss+sR..NlsD-plcsltcsGGllslshhsta.lpps........................................................spuolc-hlcHl-alsslsG.h-aVGlGoDF.....DGss........................................stulcc...................suph.pLhptLhc.cGas-p-lcplhttNhlRVhcc	.........................................................................................h.......lhDsHsDh.h.t.h..................................tt....hphsh.+hp...pGtl.s.u......thhula..h..............................................tht..p.s.h.p.t..s..l.p...t....l.s....h....hpp.hh.....p..p.......s...........s.........lt.............h..s...p...os................s...D.......l......p.......p.....s.........h.........p.....p..........s.....+..........l.u............s.....llulE......uu......csl..........sssl...............shLc.h.h..a.p.h.........G.l..RhhsL.s........a.stsN.h.u...sushtp....................................ttsGL.o.s.h..G+p..llpch....N.clG..h.......hlDlSHhucpshh...-sl.............ph.o...p....t......P....ll.hSHSs.....s...p.ul.............s.........s.........p.s.........R................NlsDc.l....ctl........t....c.....p......GGllt.....lsh.....hstF..lpst...............................................................................................tpssl.pc..h....s.....cHlcalhpl.hG.....h-.p....lGlGoD..F............DG.ht.t...........................................................................................................................................................................................stslps............................s.u.p.h.s....plhtt.Lhc....p....G.........asc.........pclp....cl....h....ttNhlRlhp.t....................................................................................................................................................................................................................	1	281	511	734
+4114	PF01664	Reo_sigma1		Reovirus viral attachment protein sigma 1	Bashton M, Bateman A	anon	Pfam-B_1003 (release 4.1)	Family	This family consists of the reovirus sigma 1 hemagglutinin, cell attachment protein. This glycoprotein is a minor capsid  protein and also determines the serotype-specific humoral immune response. Sigma 1 consist of a fibrous tail and a globular head. The head has important roles in the cell attachment function of sigma 1  and determinant of the type-specific humoral immune response [2]. Reovirus is part of the orthoreovirus group of retroviruses with, a dsRNA genome. Also present in this family is bacteriophage SF6  Lysozyme Swiss:P21270.	25.00	25.00	43.90	38.50	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.31	0.70	-5.26	3	60	2012-10-01 20:11:45	2003-04-07 12:59:11	11	3	13	30	0	78	0	208.30	62	46.59	CHANGED	IsuLPSRlGoLEuS+IDSVlPPLslpSouuTRlLchhYDoSDFsIsNSVLoLRsRSToPTaRYPLELsSAsNpVulucNYRhRpGpWoGQLpYpsPuLsWRAsVTlNLM+VDDWLlLSFopFoTsSIhAuGKFVLNFVTGLSPGWtTGDTEPSoT..lsPLSTTFAAIQFlNGGuRlDAFRILGVuEWsDGELEI+NaGGTYTuHTNVcWAPMTIMYPCss	.FDuINSRluslEQSYVASsVsPLRLNSS..TKVLDMLIDSSTLEIN.SSGQLsVRSooPNLRYPIsDlSGu..IGMSPNYRFRQSMWIGlVSYSGSGLsWRVQVNSDIFIVDDYIHICLPAFDGFoIADGGDLSLNFVTGLLPPLLTGDTEPAFHsDlVTYGA.pTlAIGLSu.GGsPQYhSKNLWV.EQWQDGVLRLRVEGGG.ITHSNSKWPAMTlSYPRSF..	0	0	0	0
+4115	PF04582	Reo_sigmaC		Reovirus sigma C capsid protein	Mifsud W	anon	Pfam-B_2922 (release 7.5)	Family	\N	41.00	41.00	41.00	43.10	40.90	40.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.02	0.70	-5.26	4	160	2012-10-01 20:11:45	2003-04-07 12:59:11	7	1	59	7	0	145	0	239.10	45	97.25	CHANGED	MAGLsPpQRREVVuLILSLTSSsThNsGDLTslYERLosLEuustSLcpSluslsoclSDlSusLQshspoLs-spusLsuLposVpALpsSVssLSoslssLoshsSuHsuulSsLQTolcuNossISNLKSsVSupGLsIoDLppRVpuLESuoSpuLpFusPLSlusGVVSL-MDPYFCSpphuLTSYSA-AQLMQFQWhA+GpsGSSsoIDMsVNAHCHGRRTDYMMSoTtuLTVTuNsVoLsFsLDhIT+hPSDLSRLlPssGFQAASFPVDVSFTRDosTHuYQVYGsYSSuRVFpITFsTGGsGTANIRFLTVRTGIDT	........................Ls..QRREVluLILSLTSssshs..GDLs.lh-RLosLEuust.Lppo.......lssh.sploslSupLpshstslspspspLpsLptplpthpssl.s..ssslsshot..pspss.losLpsphss.tstlsNL+s..sV....s....s.uL..slosLppRlpslEsssup.hphtsPLp..lssGslSLphcPhFCo.phsLoSYSspA.LhpFpW.s+.upsGuu.sslsh.lpsHsHGpRTsahhSoptshTVs.usss.Lshsls.lhp.ssD.huhLlPstGFQtAoFPVDlSFpRsssoHsY..Qs..Y..GsaspsthFplsa.ssts.st................................................................	0	0	0	0
+4116	PF00979	Reovirus_cap		Reovirus outer capsid protein, Sigma 3	Finn RD, Bateman A	anon	Pfam-B_1049 (release 3.0)	Family	Sigma 3 is the major outer capsid protein of reovirus [1]. Sigma 3 is encoded by genome segment 4.  Sigma 3 binds to  double stranded RNA and associates with polypeptide u1 and  its cleavage product u1C to form the outer shell of the virion. The Sigma 3 protein possesses a zinc-finger motif and an RNA-binding domain in the N and C termini respectively. This protein is also thought to play a role in pathogenesis.  	18.40	18.40	18.50	22.40	17.90	18.30	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.30	0.70	-5.51	5	149	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	31	5	0	145	0	250.80	49	98.83	CHANGED	MEVRVPNFHSFVEGITSSYl+sPACWNA+TuWDospFapPDVI+VGNAYCCoQCCGVLYYGuhPsDGpaFPHHKCHQQppRsDoPLLRaVRIGRTTEHLLD...QYAVtLpoIADHY--tupcpscEPtuDpVAuLDIlsRTESlRoDpAVDsDFWTsPLERRsD.DSRRDIA.oAhW+MIDASupShTLPDCLVSsuLHoRslFcQM..tTTToIYDVAsSGKsu+FSPMVAshPpR-uGPlpLsccssc-sVsosWp..sHF.......AlSPIIGGVG.IoGQatRsShHpVGHPlIGSGKKlSHYRNLFM-lsRGWSKSoFsCAsGLEPAE.sESRLRGHARTMLGRo....LPcVCDaussspossssoPLp..+osKlThlECG	.........phl-.h.sua.th...asstphWt.....h.P-hhhhGsAhsC.pChGVl..G....t...hPHH+CpQ...p.s.s.hphsc..RhTthhhc...tash.hpthhp.hp..t........tt.l.......................ps.hp.....s.............p...Wp.sl...p.....sst...h..tth.hh.ps........hlsphhh....as.thht.......hoIYDVAsSGK.ul+FS..PMVushu...pR-uGPlhLssssst-sVhohhp..uHF.......AhSPllGGVu.loGpatRtShH..hhshltsstKhp..Rph..t...sat..ththhhs............................................................h................	0	0	0	0
+4117	PF01446	Rep_1	Rep; 	Replication protein	Bateman A	anon	Prodom_1565 (release 99.1)	Family	Replication proteins (rep) are involved in plasmid replication. The Rep protein binds to the plasmid DNA and nicks it at the double strand origin  (dso) of replication.  The 3'-hydroxyl end created is extended by the host DNA replicase, and the 5' end is displaced during synthesis. At the end of one replication round, Rep introduces a second single stranded break at the dso and ligates the ssDNA extremities generating one double-stranded plasmid and one circular ssDNA form. Complementary strand synthesis of the circular ssDNA is usually initiated at the single-stranded origin by the host RNA polymerase [1].	26.00	26.00	26.20	26.10	25.70	25.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.67	0.70	-5.02	25	775	2012-10-02 18:54:06	2003-04-07 12:59:11	12	3	413	0	22	552	35	156.80	31	69.80	CHANGED	hKhuhpsppIlscuhpcpPpuRaLFLTLTV+Nsp..G-cLcpolspMscuFpRLhpaKK.........hppsllGalRusEVThNc.pcs.....oYHPHhHVLLhVcsoYFp......pNYlsQs-WscLWc+uh........KlDYcPlVcl+sVKspp.........pp..psl..p..................sAlhEsuKYsVKssDhhsssp......ts.pslh-LppuLtppR.IuaGGLLKpI+....+cLpL-DsE..puDLlpss--ccp.spsp......plhhhWphpppsYhl	.........................................th.....t...t...h..lFLTL.oh..Ns......hpp...Lpttlpthtpu...ap+h...phpp....................h.ts.....hhG...ah...+thE.l.Thsp......ps................................ap.HhHhllhlp...shht.......t.altp...tpW.phWp.p.sh......................ths.....s.......hplp.hp..........................................................................h.p......h...............................................lsauGlhKph+.......K.Lp....s-h........shlp..p.pp............phh.......................................................................................................................	0	8	12	22
+4118	PF04057	Rep-A_N	Rep-A_protein_1;	Replication factor-A protein 1, N-terminal domain	Wood V, Finn RD	anon	Pfam-B_6000 (release 7.3);	Domain	\N	21.70	21.70	22.00	21.90	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.19	0.72	-4.22	11	381	2012-10-03 20:18:03	2003-04-07 12:59:11	7	20	239	3	250	351	3	97.50	29	16.47	CHANGED	LTsGAIutlhs....u-ssh....cPVLQVl-lK.Iss.......sspRYRhlhSDGpst.hpu.MLuoQLNshVcsGplppsullpLpcalsNslpt...sR+llllhpLEVlsp	.......................................................lo.GAlttlhp.......spss......pPllQllsl+..lss.............sssspRaRllhSDGhph.hpu.MLATQL.NphlcsspLpp.s.sllplpc...ahssslp........s++.l.lI.lhclEVlt.............................	0	86	146	208
+4119	PF01719	Rep_2		Plasmid replication protein	Bashton M, Bateman A	anon	Pfam-B_1901 (release 4.1)	Family	This family consists of various bacterial plasmid replication (Rep)  proteins. These proteins are essential for replication of plasmids, the Rep proteins are topoisomerases that nick the positive stand at the plus origin of replication and also at the single-strand conversion sequence [2].	25.00	25.00	25.10	25.10	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.46	0.71	-4.80	24	278	2009-09-17 10:57:14	2003-04-07 12:59:11	12	4	204	9	32	240	1	182.60	27	74.28	CHANGED	hsKcpt.............RpWsFllYP..ESh.....PcsWpphL..-phtl.hhhSPLHDKDls.............psGchKKsHaHlllhacsspohppVpplhcph........susthspl..tslcshYcYhsHts....s.cKapYshs-IhshsGF.....DIcpalshssp.c+.p..llppllchIc-pslh...php-Lhpashppt.c..hhslhtppsh..........hFhspY.lcupptp	.................................................................................pt..........phasFlhY....ESh.....Ppsahp...hL......-pht.lsh.hhSPhHDKDls..............psschKKs...HhHshhhacshpohsplppllpph..............sssthlphh....hS.....pshapYhsHtp....ss-Kp....YshpDItshsGF...........-l-calh.ssp.p..p.p.....hlppll-hIccpshh...php-Lhtahhtpt.p...hhshhh.ps...........hh.ttY.cpth..t........................................................................................	0	2	6	23
+4120	PF01051	Rep_3	RepB_protein; 	Initiator Replication protein	Finn RD, Bateman A	anon	Pfam-B_313 (release 3.0)	Family	This protein is an initiator of plasmid replication. RepB possesses nicking-closing (topoisomerase I) like activity. It is also able to perform a strand transfer reaction on ssDNA that contains its target. This family also includes RepA which is an E.coli protein involved in plasmid replication. The RepA protein binds to DNA repeats that flank the repA gene [3,4].	22.40	22.40	22.90	22.40	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-4.75	166	2007	2012-10-04 14:01:12	2003-04-07 12:59:11	16	8	1146	6	232	1665	74	220.10	17	69.43	CHANGED	ppthlhpsNsll.psshp........hohtEh+lhhhhluplcsp..ttpt.....................h.h...phtcht.th....shspps....hpplppshppLh.cch.hph.......................tppht.hhhhhtahp...................tpuplpl..phspclhshLhpL...pp..p..F.TpapLpphtp.l.cSpYohpLYclL.....ppa....................cs....hsp..hp..........hsl.......-...........-h+p........hhsl.........................sph.phschcp+VL.csulcE...lsp........pssh.tlphcph.+...pG.......Rp...lsslpFph	.....................................................................................t...hh..pNph.h.ps..t.......hshhphplhh...hhltphppp......pptt..................................hph.....shpchh.th...............thpsps........hpplcpshppL...pp..hph...............................pt.......hh.ahs.h...............................tpshlpl.....phs.sp........lt..hlhph........pp...t...a.sphplpphsp.L.cup..auhpLa.clh..........hpa.........................ps....ttt........hh...........lpl...........p...............................-h+p........hlp.l...........................................tsth...phs..phcp+ll..csslp-.....lsp........................hsph..tlshpph..+.........cG....Rp....l.th.F........................................................................................................	0	58	131	189
+4121	PF02486	Rep_trans		Replication initiation factor	Mian N, Bateman A	anon	Pfam-B_2164 (release 5.4) & COG2946	Family	Plasmid replication is initiated by the replication initiation factor (REP). This family represents a probable topoisomerase that makes a  sequence-specific single-stranded nick in the plasmid DNA at the origin of replication. Human proteins also belong to this family,  including myelin transcription factor 2 (Swiss:O15150) and cerebrin-50 (Swiss:Q16301) [2].	29.60	29.60	29.60	29.70	29.40	29.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.19	0.71	-4.80	84	1463	2009-09-11 00:34:10	2003-04-07 12:59:11	14	8	833	0	83	967	19	187.80	25	54.34	CHANGED	hhssploRlDlAhD.hpt..........hshschhpph.ppsthhpph.........p...............hpphushp.............hGpThYlGu+.pSp...hhhRlY-KshE...............t..p..WhRhElcL+spct..hshchlhs.....tp.hsshhhthhphh.....................................t.tthpl.....ssphp..ths.......................h-pt....hpalpc....psutslphltph.t......................tphpshltpllpp	...........................................................h..sthsRlDLAlD-hss.........hhshspltcch.pptchhsth................hp...................hpphtssp.......................pt.thGpT.hYlGSp..pSp......hahplY-KshEph.......................t..hcp..sph..hsRhElcL+pccs....h....hshc.Lhs..............hp...hpthhhthhsthhphh................................hhtthp.lcl.........ssp.c....ho...........................hccs.....hpWlp.+....Qs.u.slthh..ph.t............tpphh..h...p...........................................................................................................	0	24	46	64
+4122	PF04796	RepA_C		Plasmid encoded RepA protein	Waterfield DI. Finn RD	anon	Pfam-B_6223 (release 7.5)	Family	Family of plasmid encoded proteins involved in plasmid replication.  The role of RepA in the replication process is not clearly understood [1].	21.40	21.40	21.50	21.60	18.90	21.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.90	0.71	-4.63	10	189	2012-10-04 14:01:12	2003-04-07 12:59:11	7	2	146	0	63	178	18	157.60	32	48.85	CHANGED	lPYGshPRLlhsaLsT......cAl+o+o.............slpLGpShocFlccLGhps..oGGtpGslsslR-QlsRLuussh..........sluhcsuscu..sspshslhccthhhW.spcss.....QpuLas..SpVpLopsFFcpLtc+PVPlDhsAl+tLppSPhuLDlYsWLoYRlphl..s.+s....ssloWcp	.................................................................lPYGshsRLlLhalsT......pAl...+s+sR............clpL.G...pShspFh.c.t.hGlss..pGGc..shptlRcQhpRLhuspl...............................................phthp..s....sts.........thh.shthscph......h..h....h.hps.p..pss...............Qt.uh...at....sh.....lpLS-sFappL.hc+sVPlDhcAl+tLp...t..SshAlDlYsWLsYRlatl....p..+s....shlsWp.s..............	0	21	45	54
+4123	PF01421	Reprolysin		Reprolysin (M12B) family zinc metalloprotease 	Bateman A	anon	Swissprot	Domain	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.  Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin Swiss:Q28472.  Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.29	0.71	-4.73	38	3201	2012-10-03 04:41:15	2003-04-07 12:59:11	14	123	179	77	1444	3423	29	190.20	28	23.35	CHANGED	+YlELhlVsD+thap+hsushstl+p+lapllNhlNphYps.LNlpVsLsuLEIWospDpIslpssussTLppFspWRcp.Llp++pHDsApLLouhsass.slGhAahuuhCsscpSsGlspcap..pshhlAlhMAHELGHNLGhpHDst.....tCpC....ssssCIMss.huppsuh.hFSsCShppappFlpptpspClhNpP	..................................................................................................................................................+alEhhlVsD.pt...h...h......p....h........h.....s.....t.....s.....h......p.....t..hp.p..hlhpl.....h..N..h..........l......s...t..h...........a........pp........l......s.........l....p.......l....s...L.......l...s...l......t.....l..............a.........s.............p...........p............s...........t........l.......p......l...........s..................t.........s...........s.................s.......p..........o...L..p...sF.....s......p.....W.....p...p.............p.............h....h......t........p...........p...............p...........H...............D.....s.........A........h..L.l..T.........t.........p.............s..........h..........s.........s.........t..........s.............l........G............h.....A................l.........u.........uh.............C......s....s...t.........p..........S............s.......u.............l.s........p................-..............p...........................s.........h.........sh.A..............h......oh..........AHE..l.G...............H............s........lGMp.HDss.............pC......p.........C.................sttss......lM......us....h.......s......t.......t...............s.h.....taSsC..Stpp.h.pp..a......L....p...p.....t..t....s...p.CLhs.P................................................................	0	219	301	684
+4124	PF05140	ResB		ResB-like family 	Finn RD	anon	Pfam-B_1866 (release 7.7)	Family	This family includes both ResB and cytochrome c biogenesis  proteins [1,2].  Mutations in ResB indicate that they are  essential for growth [1].  ResB is predicted to be a  transmembrane protein [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.68	0.70	-5.94	127	1951	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	1367	0	559	1727	720	307.30	18	58.66	CHANGED	h+hAlhLLlllAluSlhGTllP.Qp................ss.Yhppa........G..hhuplh.pLsL.clYsShWFhsllhlLslSLlsCslpRthshh+sh+ph..htptp..Lp+hshttphph...........................s.psshppltthLcpp.tac..lptpptp.................lhAcKGhhs+hGsllsHhullllllGuhhuuhh....................................uac........uphhls..pG...........psssh......sG..........saslclccFpl-ahs.................sG.tscpFtSclslhcss...........pp..hpptplpVN.cPLpacGhslYQssau.sshphhthsssh....tt....h.phshphhs.sst...............................plplhuhhhs...........................................................pp.psssPsltlplhs.ptth......................................................................................................................sspspthhthphsphpthphssh.........................................................................hlph...........stshp......hoGLplp+DPGhslValGshlhllGlhhuhalpcRRlWlhhps...........................tsplhluGhss+sphu.atcEhtc	............................................................................................................................................................................................................................................................................................................................................htc.h..s.hh.Hhuhlhhhhuhhht..........................................................................................................................h..p..t..h..l...ts.......................pt....h................................hsaplplpcF..hphhs.....................................................................................................pt...sppatopltlhptt.........................tp...hphplthN.cPLph.t.Ghp.h..Y....ua.s..s..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t............................................................................................................................................................................................................	0	197	410	519
+4125	PF04851	ResIII		Type III restriction enzyme, res subunit	Finn RD, Mifsud W	anon	Pfam-B_4631 (release 7.6)	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.52	0.71	-4.46	55	18536	2012-10-05 12:31:08	2003-04-07 12:59:11	10	220	5248	26	4564	43274	12710	160.50	19	20.83	CHANGED	phphRsaQtpAlcplhpthppt...............................ppcsllhhsTGoGKThhuh.........t...hhtclhp..................+sLFls...sppsLhcQsh.cpa........................................pttt.th..t...pstphhhsslQpLpt.................................ph..stas..................lllhDEsH+ususs...................applhp.................hpsthh......lGhTATP..pc	............................................................................................................................................................................................h....p..Q.pAl..p...p....lh.p.t...hppt......................................................................................................tp.pt.l..l....h..t..sT...G...oGK....T..h..s..h.h...................................................................................p......hh..t.p.ltc.................................................psl..l....l...s.......s...p....p....s....L....s......s...Q...hh...pch.............................................................................................................................................................t.........h...............t.....t....t......t.......h..................................................................t...........t..........t...............t.....h.......h.......h..............h..t......h.................................................................................................................................................................................................................................hh.l...h.DEs.......H....t.........................................................................................h.t............................................................h....h.o..uT..................................................................................................................................................................................................................	1	1830	3138	3952
+4126	PF00239	Resolvase	recombinase; resolvase; 	Resolvase, N terminal domain	Finn RD, Griffiths-Jones SR, Bateman A	anon	Prosite & Pfam-B_3830 (Release 7.5)	Domain	The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface.  The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see Pfam:PF02796.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.83	0.71	-4.32	222	13550	2009-01-15 18:05:59	2003-04-07 12:59:11	16	84	3644	51	2369	10593	1582	133.80	24	45.62	CHANGED	hhuYsRV..STpc....Qs.....hppQ.hptLcphu.sp.........p.l.....at-c.hSGpp....t.p..R..stlpchlp.tlcp..s...D..s......llVtclDRLuRs.ht-hlpl.lcpl.pppGlplhsls..p......hcs............sssh.uch...hhslhush....Ach..E+phlp-RsppG.lttA+t...pGch	......................................................................hhYsRl...Sotc............Qs..........hpt..Q..h.....p..t..l.p.p....hs.pp................t..l.............apD.p.....hSGtp.................h.p.......R........sthpc.h.lp...tlcp.........s.....D....h..............................llVtclD...RL.uRs..ht-h.hph..l.p..tl....p...p......p..s..lp...l.hsls..p..s............hcs......................................sssh...sch..........hhp.l..h.u.s.h..................Ach......Epc.........h..htcR.hpt...Ghtt.ttt.pG...............................................................................	1	844	1618	2027
+4127	PF00072	Response_reg	response_reg; 	Response regulator receiver domain	Sonnhammer ELL, Griffiths-Jones SR, Finn R, Fenech M	anon	Prodom	Domain	This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.07	0.71	-4.06	57	151337	2012-10-01 22:20:39	2003-04-07 12:59:11	19	3468	5531	462	44329	116945	19054	111.60	26	30.95	CHANGED	lLlV.DDcshhpphlpphlp.....p.tuh...pVs.tsssuppulphl....pppp.....hDlllhD..........lphPs..h...sGlclhppl.+pps...s...ssllhlT.upss..thshpul.psG.ApsalsKPh.shscLhptlp	........................................................................................lLlV...-.D..c.........h....h....t....p....h....l....p....p....h.Lp.............p...tu....a........................p........l.......t.....t.....u.........s......s..G.....p....p..A.l..p...h.h...................pp..pp...........................................D.....l......l..l..h..D................................................l.t.....h.....P.....s.....h................s..G.....h.......c.....l......h...c.....p....l....+ppt.....................p.........................h..P..l..l............h....l........T.....u........p........s........p...........t............s.........t..........h.....p.......u...........l.....c...........h......G......A.....s........-....Y.....l...s...K.P...h...s...pc.Lhttl.t....................................................................	2	15208	29453	37848
+4128	PF02813	Retro_M		Retroviral M domain	Bateman A	anon	Bateman A	Family	Retroviruses contain a small protein, MA (matrix), which forms a protein lining immediately beneath the phospholipid membrane of the mature virus particle. MA is located in the N-terminal region of the Gag precursor polyprotein. The N-terminal segment of MA proteins directs the Gag protein to the plasma membrane where budding takes place, and has been called the M domain.  This domain forms an alpha helical bundle structure.	25.00	25.00	25.40	42.10	24.10	19.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.96	0.72	-3.82	3	206	2012-10-01 20:35:47	2003-04-07 12:59:11	9	15	46	1	0	218	0	81.30	90	16.63	CHANGED	DsVIKVLsohCKDYCGKTSPS+KEIuosLSLLpcEGtLcSPSDIausupWDhlTAALoQRAMsuuKAGELKTWGLlLGALKAAREE	...............ACKTYCG.....KTSPSKKEIGAMLSLLQKEGLLhSPSDLY.....SPGSWDPITAALSQRAMVLGKSGELKTWGLVLGALKAAREE.	0	0	0	0
+4129	PF00424	REV		REV protein (anti-repression trans-activator protein)	Finn RD	anon	Pfam-B_169 (release 1.0)	Family	\N	20.80	20.60	20.80	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.33	0.72	-4.09	13	15943	2009-09-12 07:43:04	2003-04-07 12:59:11	13	3	89	13	1	6741	0	83.00	60	88.13	CHANGED	Mst+st...-EtL+RtLRLI+lLaQoN.PYPp.ssGTApQRRpRRRRWRpR.cQIhALA-RIhsh..-.PhspPlDptl.cLQcLsIQpLPDP.....................Psss	......................................................................................................P..Po....sEG.T.RQA.RRNRRRRWRpRQR.QIcu.ISthILSohL......GR.P.sEPVPLQLPPLERLoLDCsEDC.GT.oGTpsssssphh............	0	1	1	1
+4130	PF00472	RF-1		RF-1 domain	Bateman A, Finn RD	anon	Prosite	Family	This domain is found in peptide chain release factors such as RF-1 (Swiss:P07011) and RF-2 (Swiss:P07012), and a number of smaller proteins of unknown function such as Swiss:P40711. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.	21.30	21.30	21.50	21.40	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.28	100	11930	2012-10-03 10:08:23	2003-04-07 12:59:11	15	22	4796	19	3127	8043	5160	115.70	40	37.79	CHANGED	.hstsh.clplsts-lclcsh.RuoGsGGQpVNKssSA....................V+l.pHh.......Pou..................lllpsQppRSQhpNRcpAhchLpu+Lhph...t........hpcpcppppsp+tuphcph-tupc..hRsYsh..psplKDtR	........................................cphclcIs.s.sDl+lD.sa.R.u.SGAGG.........Q+V.N+..T-SA...........................................VRl..THl.........PTG..............................................IVVps...Q...s-RS..Qpp......N+cpAhphLp..A+L.hph.p......................hpcp...p.t....pt..s.s.tR.p...s...p...h..t...t..h...s....tu..pp..IRo..Ysh...PpsplpDhR..............................................................	0	1030	1966	2619
+4131	PF04506	Rft-1		Rft protein	Wood V, Bateman A	anon	Wood V	Family	\N	20.80	20.80	23.20	22.70	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.70	0.70	-6.14	4	365	2012-10-02 21:24:20	2003-04-07 12:59:11	8	9	278	0	263	371	4	394.10	23	88.38	CHANGED	pSShpGhsaslhhQlhsRIlTFhlNthllRhlusclhGlssl+LplLpSTlLFLSREulRhAtlphsups...h.pss.tch.pphaLSs.lpsllss..sYI.h.aluhs.ulhhSha.ahslss....lh.shucsslFlhhl.phlcL..L.psaahlsQhhlhhstpstscuhuhhhsulhphtlsshs...p.............cuhuhL.Fshsslu.plp.huhhca.thps......FSshLsKltp.......p.......haasp-hlphhhohhhQslLKpLLT-G-Khlhsh..lhShp-QusYsllsNhGSllsRhlFpPIE-ssphaFuphlppcsphsp......+pulslLsplL+hhuhluhlhhsFG.sYSshVL.hhuGscaussus.tslLphYshYI.hhAlNGIhEuFhhusssucQIhcauhhhhshSlhaLlhualLhsh..hustGhIlANIINMslRIlYshhaIp+.a+-hshs.ohshshh.sphhlhshhhusllsaWh.ups.hLsahlsslhhuhshLhhhhlsc+phhphhhhhhsphthK	................................................t..........hhhQlh.+hhoFhhNthllR..hls.t...hhGl..s...pl..lh..ohlFhuREuhRhuh.p.......t...................................t.............t............................................................thh..hs.h.......hh...h..................................h...................................h.h....shh..lh.h...s..hhlcL..hsEs..h..a....h.l.p...h.hth.+..hhc.....s.h.....uh..hhh.sh.h.p.hh..hh......h.h...................................................hh....h.h...h..h.......h.hh....h..h.......h..................................................h........h......h..........................................................hp....t.h...ph.hhp.hhhQuhhKplLT-.G-p..hlh.s...h...h..............ohtpQG.hYslssNh........GSLlsRhlFtP..lEEo...hhhFup.............h.l...................t.........p...........t.........p........t...................p................................................................................t......sh.....p..........h.L....t.......ll+hhhhluh.hhhshG..shu.hhLpl.h.....h...G...t..t..hs...sst.......s.......................hLphY.......s.h...Yl...................hL........AhNGlhEs.Fh.ushs.t.pp...............ltp..shhhhhhShhahh...hs...h..h.hh......t..............hG...s....G.............hlhANhhNMhh.RIhas....hhal....tp.......h.h.......t.....t............................................................................................................................................................................................................................hh.hh............................................................................	0	96	153	222
+4132	PF04589	RFX1_trans_act		RFX1 transcription activation region      	Kerrison ND	anon	DOMO:DM04454;	Family	The RFX family is a family of winged-helix DNA binding proteins.  RFX1 is a regulatory factor essential for expression of MHC class II genes. This region is to found N terminal to the RFX DNA binding region  (Pfam:PF02257) in some mammalian RFX proteins, and is thought to activate  transcription when associated with DNA.  Deletion analysis has identified  the region 233-351 in human RFX1 (Swiss:P22670) as being required for  maximal activation [1].	25.00	25.00	28.80	28.80	18.60	23.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.25	0.71	-4.49	8	197	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	39	0	75	132	0	135.80	50	21.09	CHANGED	MQsSEuGSDosuoV.sLpTSsuuQu....sVPuoQpRslVQshsps.Kst.sQQl......sV.hsQQVsQQVQQ..VQHVYsuQVQYV.EGu-uVYTNGsIR.oAYoY.sEoQlYuQoSGuuYFDoQ...GuuAQ.....VTTVVSS.......HoMV.......GIsMsVuG.SQIISSo.uuYLItGG	.......................................psucsuusssuoV..tLpspsstQ......Vs.sp.................sQ.l......sV.......p...s.....Qp.VQQ...VQHVYPuQVQYV.EG.uD..sVYTNGAI.R.osYsY.sEoQhYoQs..o...uusYF-sQ......GouAQ.......VTTssSS.......HuMV.....soGGIsMsVsG.uQllSSo..GsYLIts.s............................................................	0	3	8	28
+4133	PF02257	RFX_DNA_binding		RFX DNA-binding domain	Bateman A, Mian N	anon	Pfam-B_3682 (release 5.2)	Domain	RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer [1]. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD) [2].	27.00	27.00	27.20	27.30	26.40	26.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-9.78	0.72	-3.84	34	732	2012-10-04 14:01:12	2003-04-07 12:59:11	10	11	217	2	423	656	0	83.20	43	10.10	CHANGED	c+p+phaA.hhWLhsshE.tsp.ssslPRs.......................plYscYhptCsppp.lcPLssAoFGKLlRslFPsl+TRRLGs..........................RGpSKY....HYs.....Gl+l+sss	...................p......hs..hpWLhsshE..pspssslPRs.......................plYscYhpaC..............p.............p..............pp.h.cP.lsuAoFG.......KlIRplFPsl+TRRLG.o..........................R..GpSK...Y..........H..Yh.....Gl+lK...s................................	0	100	152	268
+4134	PF03214	RGP		Reversibly glycosylated polypeptide	Mifsud W	anon	Pfam-B_2662 (release 6.5)	Family	\N	23.80	23.80	29.90	29.80	23.70	22.40	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.19	0.70	-5.70	4	169	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	63	0	94	181	3	299.80	50	91.75	CHANGED	MSh..IpcsEVDIVIuALpsNLTsFhppWRPFFStFHLIlVKDP-hp.cclplPEGFss-lYs+oDhE+VlGup.sSIpFSGauCRYFGaLVSKKKYlloIDDDClPAKDsuGhsVDAVsQHlhNLcoPATPFFFNTLYDPaRcGADFVRGYPFSLRpGVsCAhSCGLWLNlADhDAPTQslKsppRNTpYVDAVMTVPttAMhPlSGINlAFNRELlGPAhhPALhLtGEGKhRW-TlEDlWsGhCsKllCDHLuhGVKTGLPYVWRs..EtGsAl-SL+KEWEGlKlMEcllPFFpSlKLspTusssEDCVIELActVKEpLGp.DPhFsKAADAMhcWlcLW+Slss.SA	....................................................................................................................................................s........cs-lDIVIsslp.sL.sFhp.WRPahp.aHLIlVpDsD.t.c.lplPpGFDhclYs+sD....lp+..lLGsp..ss.IsFpspuCRsFG..ah...VS...+K...KYlh.oID.DDChsA..K..D.ss..GpplsAl..pQ..H..l..pNLhsPSTPa....FFN..TLYD.PaRc.....GA.D.FVRGYPFS.L.........R..........E..........G............l........s........T..........A.........lSpGLWLNlPDYDAPTpL.V......K.........Ph.....cR..NoR...........Y..VD...A..V....hTlP+GshhPhCGMNLAFcR-LIGPAMaF..GL..hscGp.....slGRaD...DhWuGaCsKVlC.DHLGhGVKTGLPYlaHS.........KA.u.s.s.FssL+K.EacGlhhpE.-llPFFQs.....st.L.s.....cpss..oVp.pCYhE.Luc.V+p+...L..ut..l.....Ds..hFt.K.hA-AMlsWlcuWcplss...st......................................................	0	14	66	82
+4135	PF05045	RgpF		Rhamnan synthesis protein F	Moxon SJ	anon	Pfam-B_5448 (release 7.7)	Family	This family consists of a group of proteins which are related to the Streptococcus rhamnose-glucose polysaccharide assembly protein (RgpF). Rhamnan backbones are found in several O polysaccharides of phytopathogenic bacteria and are regarded as pathogenic factors [1].	25.00	25.00	26.50	26.00	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.78	0.70	-5.97	7	464	2009-01-15 18:05:59	2003-04-07 12:59:11	7	50	316	0	120	454	62	322.40	20	50.84	CHANGED	llFlSNuplocpspppLps..hsDchl.RENpGFDhhAa+-Gl-hlGFDcLspYDplhlhNcThaGPla.huphFpchEp+.ssDFWGIosH+thp.s....tsthhscHlpSaFIuh+psllpSpsFcsaWcshsphpsht-sl.haEophTshFhshGaphpshlDoc+hsusa..hlcsD.ohhs.ssILK+Rl.Fhcsphl-spth...hPhhLchlccsosYslsLIhcpl.chu.P.sLs.....h.lLsschlps.ttss.sptKlAVphHlYYsDhL-EhLshhpNhshsYDLhlTTsos-K+tEIcph.L.ptsG.pss.VhVs.tN+GRDhsshh.sL+-hL..c+YDhVs+hHTKKS.pssh.tGp.a+cchl-.Llcs...scNlLshFcpNsplGlslssl.sahpasplspAW.tN...tsphtclh+phslph+hD....sT.VhuYGThaWF+.cAL+pLF-hchp.cDhssEP.hspsolhHAlERLlsYhAhssuY	................................................................................................................................................................................s.....h............t.l...........h.t...hh.RpN.GaDhhuappu.h....h.....t..h..ph.splhlhNco..hG.Ph.........ht...hh.tp..ht..t.p....thDhaGho.......t....................................h..HlQSaahsh....pt.hhts..F.paWpth...h.p.s..htpsl..aE..hophh.p..Ghphtsh..h..........................................................h.................hh......t...............................................................................................................................hhhhHhh...hh.th.t.......h.........hphhho...h.............h.t...h.................h......ph.psh..hh..........h....t..hthhhhhps...+p..........................................t.t.h.t....hht.hh...........htt...h..t.http..hu.hhhs.......................................................................h...h...th.........h............................G...shhah+......thht..h.t......t..............h....................t.....hE........................................................................................................................................	0	26	73	97
+4136	PF00615	RGS		Regulator of G protein signaling domain	Ponting C, Schultz J, Bork P	anon	SMART	Domain	RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.78	0.71	-4.00	74	4150	2012-10-03 22:10:09	2003-04-07 12:59:11	14	139	303	83	2509	3808	11	120.60	21	22.88	CHANGED	ohcpllssps.GhphFppFLcsphsc..-slpFWhusc-a+pt..........................sppchhpp..AppIapcalt.sus.ppl.sl-ppstpthppslpp............................ss.shFc.tuQpplhp.hhcp-sas+FLcS..shYpch	.........................................................................hppllps....uhthF.p....p...F..L.c.p.ch.st...........-sl.............p.....Fa...hss.c.ca+ph.............................................................................................................................s.p.p..p.htpp......uppI..a..ppa.l....t.........s..p....us...p.........p....l...s...l.s...p......p.....s..p..p..p...l..p..p..p.lpp.......................................................................................................ss.ph.Fc..pup..p..p.lhp.....hh..c..p..c..s..a..scFlpS.tha.p........................................................................................................	1	835	1141	1805
+4137	PF00974	Rhabdo_glycop	Rhabd_glycop;	Rhabdovirus spike glycoprotein	Finn RD, Bateman A	anon	Pfam-B_167 (release 3.0)	Family	Frequently abbreviated to G protein.  The glycoprotein spike is made up of a trimer of G proteins. Channel formed by glycoprotein spike is thought to function in a similar manner to Influenza virus M2 protein channel, thus allowing a signal to pass across the viral membrane to signal for viral uncoating.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	501	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.53	0.70	-6.27	8	3017	2009-09-17 10:48:14	2003-04-07 12:59:11	13	3	114	5	2	2015	0	333.50	41	96.20	CHANGED	hlslllllthsss.hsp..PlhssssspssWs.Pl.sashsCPssthspscuupspsPhpac-.ssGhlosspV.GalCpu....slapsssah+aVGY+shT....Fut+slcPTls-C+tAhpchssGsspsppsLaFPsPsCtWhosVsss-tshhhlTP+oVplDsYstcalDscF.uG+Copps.....CpTpassolWhs-ss.hpstCsp.hpplcGhhasspsSppsshus....cpGa+Pah.LcsuCplsFCGK.GIRhspG-Wlulsss....sssphhshPpClss.....lsshRssts-ashls-Ll+...cRpECL-sascIhsopsloshcLS+hRshtPGhGcsYslhNGoLhcupspYlpV-h...-lh.s+ssh+stspsshhhWsph..FGshhtG.cGlltss..phphP.lppasulh-suhh.hhpst.lPHPshpsspsspD.......hhsschts.tpsl-slDhthssWuhalhluuhsllsllLllllhpCCshssp..pPptppsIshpphsps..p	............................................................................................................Wp.sl.ht..tCsp.s......s.......cs..s.p....hsshpa.c..p.uhlss.ph.tahshu....shhtsts.hphhshhshs....athpphc.h..ts+.uhp.thstssphcts.h.P.PshtWhpsshppc.ohhhloPpssplDsYs+phhsp.F.sGcCps..s.......CpTpashslWhs-ps....tspCDh.......hp..s.....cG......hh.ss....c..ts..c..p.sshss................ptGha....LctACplphCGh.Gl+h.pGshlthps..........ssth..hhs....Pcphss..................hhsh+.ssp.-a.....hl..p.-.L.l+.......pRp...c...CL-shppIhsstslo.h.LShht....G.s...sahh..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	2
+4138	PF03342	Rhabdo_M1		Rhabdovirus M1 matrix protein (M1 polymerase-associated protein)	Mifsud W	anon	Pfam-B_3629 (release 6.5)	Family	\N	25.00	25.00	319.20	319.00	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.29	0.70	-5.21	4	24	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	9	0	0	24	0	221.50	62	98.90	CHANGED	MuD..p.GEphhs..u.sLhcL-u+LcN.s.cDuplsth.u..KcssshptE...osK+pscPp....LEpllL+aVsEcpplDAhKcFGtLItpI+.SHQtELTpHLE+VusEpRANLpALhcSQpEppKsoKpILSslIulRuplsENuS.+PKsLDhDQV+sERALGFshGYpTAlslhs+lKshsPppssptpVKshAlpAhEc-EYEGStphF+pVlctlKtchc	MuD.IEMuEpLVLSHG.SLADLD+RLDN.APKDsRuALFSS..sssso+QKs...SPKKKssPT...TLEElIGHFVsEDLQLDAsKAFGQLLRRIKhSHQEELTQHLEKVNsEpRAKMGALLESQKENGKKTDNILSILIuMRGEGAENASKKPKVLDGDQVRNERALGFNRGLTTAAIAMKKFKLEDPLsLCKGSVKRAALSAMEKEEYDGpRETYusVuKAlKA-lc.	0	0	0	0
+4139	PF04785	Rhabdo_M2		Rhabdovirus matrix protein M2	Kerrison ND	anon	Pfam-B_2486 (release 7.6)	Family	M protein is involved in condensing and targeting the ribonucleoprotein (RNP) coil to the plasma membrane.  M interacts specifically with the transmembrane spike protein (G) is important for the incorporation of G  protein into budding virions [1].	25.00	25.00	414.40	414.30	16.80	16.70	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.28	0.71	-5.28	4	134	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	30	1	0	136	0	202.00	89	99.89	CHANGED	MNhLRKhlKoC+D-EoQKssssSAPPDDDDLWLPPPEYVPLpEloGKtNhRNFCIsGEVKlCSPNGYSF+IlRHIL+SF-sVYSGNRRMIGLVKVVIGLsLSGSPVPEGMNWVYKLRRTLIFQWA-SpGPLEGEELEYSQEITWDDDoEFVGLQIRVsA+QCHIQGRlWCINMNSRACQLWSDMoLpTQQS-EDcsTSLLLE	MNFLRKIVKNCRDEDTQKPSssSAPPDDDDLWLPPPEYVPLKELTGKKNMRNFCINGEVKVCSPNGYSFRILRHILRSFDEIYSGNHRMIGLVKVVIGLALSGAPVPEGMNWVYKLRRTLIFQWADSRGPLEGEELEYSQEITWDDDTEFVGLQIRVSARQCHIQGRlWCINMNSRACQLWSDMSLQTQRSEEDKDSSLLLE	0	0	0	0
+4140	PF03397	Rhabdo_matrix		Rhabdovirus matrix protein	Mifsud W	anon	Pfam-B_3980 (release 6.6)	Family	\N	25.00	25.00	166.50	166.30	18.10	17.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.91	0.71	-4.91	10	35	2009-09-10 23:57:29	2003-04-07 12:59:11	9	1	9	0	0	31	0	165.90	66	85.60	CHANGED	KRTILlPPPHLTSNDEDRVSTILTEGTLTITGPPPGNQVDKICMAMKLARAILCEDQHPAFNPLVHLFQSAMIFGETSEKIDFGTRSKTLITSFKlAEAKAIYLDoSPVRSRIEAKKYTTPIRHGSVTYYGPFlFADDHVGGKGHREKLGALCGFLQSssYGQAKDYY	.KRTlLIPPPHLhSsDE-RVollpsEGplplTGhpPosLpEKIhhuMpLAuAIlGGD.HPuFpshsaLFQptMEFGuTpEKlsFGoRcsss.ToapVh+A+tlYLpopPl-K+IshppYosshcsuoITaoGpFLFSusHVGscDsRsKLAuL-GFhpSsSYtpsKDYY	0	0	0	0
+4141	PF00945	Rhabdo_ncap	Rhabd_nucleocap;	Rhabdovirus nucleocapsid protein	Finn RD, Bateman A	anon	Pfam-B_477 (release 3.0)	Family	The Nucleocapsid (N) Protein is said to have a "tight" structure. The carboxyl end of the N-terminal domain possesses an RNA binding domain. Sequence alignments show 2 regions of reasonable conservation,  approx. 64-103 and 201-329 [1].  A whole functional protein is required  for encapsidation to take place [2].	19.70	19.70	20.30	20.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.15	0.70	-5.88	11	7911	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	119	82	36	2619	0	200.80	64	92.45	CHANGED	ssphVss+hPs.sDssEYPhsaFpcsp+phhshhps...hDLsphRphlhsGlpuuclssscVsSYLhtshcthcsphccDWsSaGlpIu+KG-pIs.hsLlslpcpcsp...h.cGtpcssRs...s-DtaLshhLLuLYRlu+sssp...sY+sslhD+lpp.hcst...phstcphl.sstchhssWsspsNFphlsuuhDMFFpRFcpHtauslRaGTlVoRYcDCuuLsohoahhKlhsLo.hc-shpWlFs+sht-Elh+MMp.PGQEIDsscSYhPYhhshGLSsKSPYSSsssPphashlHhlGshlsSsRShNAphlsstshpclossuhlluashtucushcppFhps-cchpptcsp-tsps-ss.scs.........spus-shsWhuhapchthphscphcsah+RhVpsls	............................................................................................................................YLhush..............................................................................................................................................................................................................................................................................................................................................ttc.h+.s...ch.t.sssu..............t.........hst-sps..uhYtch.hphsp.hh.tlp+hhts..o..........................................	1	8	8	36
+4142	PF03216	Rhabdo_ncap_2		Rhabdovirus nucleoprotein	Mifsud W	anon	Pfam-B_2146 (release 6.5)	Family	\N	20.20	20.20	20.30	20.60	19.90	20.10	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.11	0.70	-5.73	4	252	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	12	0	0	122	0	172.00	65	94.19	CHANGED	uul+cpFsGLRDVKssshtspGp-acPuclpLslYt..ossDhDhphIh+AlutVGGspTscALulLhAFVhttos.sth-stsKlLp-hGFpVcplPhusslpssltsP.pcLApslspENlh-lV+GlLaTCALhsKYsVDKMtpYhppKLtcLAoSQGlsELpphsss+usLt+luuslRPGQKlTKAlYuhILlpluDPsTtuRA+ALsAMRLsGTGMTMVGLFsQAAKNLGAsPADLLEDLCM+SlV-SARRIV+LMR.Vu-AcslpA+YAlMMSRMLG-uYFKuYGlN-NSRIosILhsINs+Ys-sThtGLpGlKVSs.FRcLAccIAclLVcKYDssGssGpGASDlIRpA	............................................................................DtKVIVDALSALGGPQTVQALSVLLSYVLQGNTQEDLtsKCKVLTDMGF+VTQusRATuI-AGIhMPMRELALTVNDDNLM-IVKGTLMTCSLLTKYSVDKMIK....................................................................................................................................................................................................................................	0	0	0	0
+4143	PF02484	Rhabdo_NV	Rhabd_NV; 	Rhabdovirus Non-virion protein	Mian N, Bateman A	anon	Pfam-B_2189 (release 5.4)	Family	Infectious hematopoietic necrosis virus (IHNV) is a member of the family Rhabdoviridae. The non-virion protein (NV) is coded for by one of the six genes of the IHNV genome [1], but is absent in vesiculovirus -like rhabdovirus [2].	25.00	25.00	72.90	201.70	18.40	16.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.35	0.71	-4.18	2	24	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	6	0	0	24	0	110.50	88	99.66	CHANGED	Msp+s.sTshtAL+-lLRYKspVAtHGFLFDDGclVWpE-sDtsWpRLhsVVsALhSSpRMppsLaMDhSITKG-GaLLFsDLQGTpNh.a+pP+FRpaLh.l--FLshPR	MDHRDINTNMEALREVLRYKNcVAGHGFLFDDGDLVWREEDDATWRRLCDVVNALISSKRMQRVLYMDLSITKGEGHLLFVDLQGTKNRLYKEPRFRRHLILIEDFLAYPR	0	0	0	0
+4144	PF00554	RHD		Rel homology domain (RHD)	Bateman A	anon	SCOP	Domain	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF01833) that binds to DNA.	19.70	19.70	19.70	20.30	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.95	0.71	-4.53	21	1068	2012-10-03 00:25:27	2003-04-07 12:59:11	17	44	147	75	369	1068	0	154.90	36	22.50	CHANGED	lcIlEQP+QRGhRFRYcCE.GRSsGSIPG.tpSpcssKTaPolclpsYpG.puh.lploLVT+-pP.h+PHP....HsLVGK...c.C+cG......hhplclsP-.shs.hsFpNLGIpCV+KK-lcpslppRh.............................phs.sPap.lt.pphcthpchDLNsVRLCFQsal..cpsGsashsLsPVlSsPIaDp	...............................LpIhtQPcp+.aRhRYpsE...sS.+Gul.u...........ps..ppsaPs.V.............c..lp....sYts....sh...lpl.lsTsst.....h+PHs....HclsGK..........s..s.p.p.s.................lh..cl..t..ltPc...shh..hshsshGIhpl+.pp-lptt.h.t..................................................phs..s.hp....................shVRLsFpsal......sps...shp.hh...lhSpPI.sp........................................................	0	51	81	191
+4145	PF02115	Rho_GDI		RHO protein GDP dissociation inhibitor	Mian N, Bateman A	anon	IPR000406	Domain	\N	22.70	22.70	22.90	22.80	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.22	0.71	-4.90	16	507	2009-01-15 18:05:59	2003-04-07 12:59:11	12	6	274	48	308	499	3	181.80	38	87.83	CHANGED	MuEppspstphpphttpp-c.p.tss.........YKPPspKSlcElhchDK-DESLpKYKEsLLGsss...slsDPssP.NVhVp+lsLLssstP.slphDLoG-..lcplKcps.FsLKEGscY+lKIsF+Vp+EIVSGL+YlppTaRtGl+VDKspaMlGSYuP+.s-....Y-ahTP.EEAPpGhLARGsYslKSpFTDDDKpsHLoWEWsLpIpK-	.................................................................ptp.t..........acss.sp..KolpE...h..ph............Dt-DESLp+aKcsL...L.Gtss...............sls-s.ssP..pV.h.l.ppLsLh.sp..st...P....sl..s..hDLss..s....l.pp.h...Kcps..FslKEG.spY+l+l.sFcV.p+-IVSGL+YlppshRpG...l+...V..DK......tp.......M......lG.S.Yu.P.....p..s-...........Yphhh...s.......E...EAPsG.hlAR.GsYsspSp......FsDDDcps....H.....L..pacWshpIpK-..............	0	79	153	234
+4146	PF00581	Rhodanese		Rhodanese-like domain	Bateman A	anon	MRC-LMB Genome group	Domain	Rhodanese has an internal duplication.  This Pfam represents a single copy of this duplicated domain.  The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.63	0.71	-3.73	147	30295	2009-09-13 10:52:53	2003-04-07 12:59:11	15	226	4760	191	9427	22860	9896	101.90	20	44.29	CHANGED	ssp..pltphh.......ttsshhllDlR........sttc..............................a..............pt..........u....HIsuA....l.slsh..................................t.......htphththspsp......tl..llas................tstpustssth.....hpt.....Gap.......pl.....hhlpGGhpsWttp	..................................................................t....h.thh.......ttsh...hllD....l.R.......................ss..t.-.............................................................................................................a.....................................pt...................G......H..l..s....G....A...........l.sls.h...............................................................pt......................h.t.p...h..h....t..............s...p..s.p.............................tl.........llaC.............................ttu..cus.t.sst.h............................Lpp..h........Gap..................................pl..................h...l......p.G.GhttWt..t..................................................................................	0	2977	5838	7876
+4147	PF00620	RhoGAP		RhoGAP domain	Ponting C, Schultz J, Bork P	anon	SMART	Domain	GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.75	0.71	-4.60	87	7538	2012-10-03 21:54:49	2003-04-07 12:59:11	22	300	353	36	4418	7012	27	147.00	25	17.80	CHANGED	Phllppslphlcp.pG..lppcGlaRhuGspsplppLppth-psts..........................thpptslpsluulLKpalRcLPcPLlshphapphh.t..shph.............tstppp.....................hptlppllp..pLPpsshpsLchLhtaLpclsp..psph............N+MsspNLAhlFuPsllps.t....tsp	.............................................................................................................Phhlppslp.h.l.cp...pG............l.p.p.c......Gla...R..l..s....G.s..t....s.....p.l..p..p.........L.c..p.t.hcpst.p..........................................................t.pt.hclps....l....u...u.....lL..K.....h..a.h....R....-..L..P.......c.........P.L.....l....sh...p...h...apphl..p.......shph...............................t.stpp.p................................................................................hptl.p.p..llp.......pL......P.....p.....s....s..h..p..s.L..p.h.Lh............p..aL..p..c......l.....sp........psp..................................NpMs.s.pNLAh.lauPsLhps......sst...........................................................................................................................	0	1311	1920	3077
+4148	PF00621	RhoGEF		RhoGEF domain	SMART	anon	Alignment kindly provided by SMART	Domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	20.90	20.90	21.00	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.45	0.71	-4.40	192	7395	2009-01-15 18:05:59	2003-04-07 12:59:11	15	583	301	68	4161	6705	27	174.70	22	17.10	CHANGED	llpEllpTEpsYlpsLphl..hphahpslpp..................................pshlstpc.........lp....t..lF.u.slpplhphp.pp.....h.LppLcp.................................................tp..........pp..................l.............uclF...lp.htp..............hhph.YspYsss...hspuhphl....pp..hp.............................................ppsp.........Fpp.......hlp.hpt.............ptht........LpshLlpPlQRls+Y.LL............Lccl.lKpT.s.t..sc........-h.p....sLpp........Alptl.pplspplNc	.............................................................................................htEllpTE.ppY...l.c.p....Lphl......hp.....h..ahpshpp.............................................................................................thl..s..t...pp..........hp......h.lF..s....N.l...p....p.lh....p.....h...p..pp.....h..L.p..p.....Lcp....................................................................................................................................t...tp..............tt.pp...................................l.............................us.ha.................lp...htp.......................hh.ph..YtpYsp..s..hs.p...u..h..ph.l.....pp.......ht.......................................................................................................................................................p.p.pt...................hpp............hh.p.p.hpt.....................................s..pphs...........Lp..s...h.L..l...p........P....l..QR............ls.+Y..LL..................................L....p..c.l...l+p..o....s....p....sp....................-t..p.........pl.p...p.........................Alphh.pplhpphN.....................................................................................................................................................................................................................	1	1275	1737	2801
+4149	PF03527	RHS		RHS protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.96	0.72	-4.18	18	2442	2009-01-15 18:05:59	2003-04-07 12:59:11	9	181	606	0	216	2289	23	39.60	54	4.56	CHANGED	laaYHsDphGtPLpLocs-GchsWpAcYcsWGslhpEpssp	.....lHhYHCDHRGL...PLALlSp-Gs....T....sWsAEYDEWGNhLsEEss..........	0	42	71	144
+4150	PF00073	Rhv	rhv; 	picornavirus capsid protein	Eddy SR	anon	Overington and HMM_iterative_training	Domain	CAUTION: This alignment is very weak.  It can not be generated by clustalw. If a representative set is used for a seed, many so-called members are not recognised.  The family should probably be split up into sub-families. Capsid proteins of picornaviruses. Picornaviruses are non-enveloped plus-strand ssRNA animal viruses with icosahedral capsids. They include rhinovirus (common cold) and poliovirus. Common structure is an 8-stranded beta sandwich. Variations (one or two extra strands) occur.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.07	0.71	-4.57	50	28435	2012-10-04 01:49:40	2003-04-07 12:59:11	15	90	713	302	0	21797	0	144.60	21	43.85	CHANGED	hsssspsshss.phsshhp........h.pppsssshpth....t...t.pphht.hpshshs.ttpshhhhphsh.spthph....h.......hGthhpaaoahRsuhcl.phh..h........su......oth......ppG.........p..........h.........l...l...sh....lPsGss...............................................sssst.................................hpuhhssH.hhshttssosplslPalussshpshh...........................................pa.sshshshhshssh.sh	......................................................................................................tst..s..ths...p..........tt..ps.h.th.......t.ts..................t..h.........s........................s...............t........................h.......h.s........a.p.l.sh...ht.hsp............htphhc.haTYhRh.DhEhshh...h...........ss.......................s..........t..........h..........hha..lP.sG..ss..........................................................................................ps...s...sp........hh..p...t...ts....sphslPahu..tphh...t.h.s.........................................h..................h.................................................................................................	1	0	0	0
+4151	PF02267	Rib_hydrolayse		ADP-ribosyl cyclase	Bateman A, Mian N	anon	Pfam-B_3719 (release 5.2)	Domain	ADP-ribosyl cyclase EC:3.2.2.5 (also know as cyclic ADP-ribose  hydrolase or CD38) synthesises cyclic-ADP ribose, a second messenger for glucose-induced insulin secretion.	25.00	25.00	45.70	37.20	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.78	0.70	-5.03	12	149	2012-10-02 19:28:18	2003-04-07 12:59:11	12	3	48	156	78	136	0	212.20	38	81.23	CHANGED	Tsphp-IhLGRChpYs.....thhpPt................tphsCpsIhcsFhpAhhsKsPCsls.pDYcshhpLsspo..lPssKolFWSpsp..plsHsasp.sppchhTLEDTLhGahuDsLsWCGp....tssSthsapsC...Pshpc....CsN..NshssFWppsSppaAcsAs..........................GlVpVMLNGSps..ss......asppShFuslElssLpss+VsplplaVhc-ht.....sssp-oCusuSltpLcphlps+shtasChss.+slhhLQClcpsppssC	...............................ph.plhluR.Chpah.......hpst....................t.phsCptlWcsF.ps...hh...s..K...s...PCslh.pDYp.h....hp.L...stps......lPpsKolFWppsp...lsppasp...sppc.hhsLpDs..LhGhhsDtL....sWCGp.....pss.sthsY.p.SC...Ps.pc....CpN....NslssFW+puS.tpaAcsus..........................GslpVhLNGShs..ss.......as.hpuhFushEl.sLp.pKVpplplaVhaplt.....s.s.s...h-oCupsSlp.LcphLpp.hshpaoChsshc.ssph.l.Chcpspp.tC.......................................	0	22	23	41
+4152	PF01872	RibD_C		RibD C-terminal domain	Enright A, Ouzounis C, Bateman A	anon	Enright A & Pfam-B_6425 (Release 8.0)	Family	The function of this domain is not known, but it is thought to be involved in riboflavin biosynthesis. This domain is found in the C terminus of RibD/RibG Swiss:P25539, in combination with Pfam:PF00383, as well as in isolation in some archaebacterial proteins Swiss:P95872.  This family appears to be related to Pfam:PF00186.	20.50	20.50	20.50	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.29	0.71	-4.71	27	7001	2012-10-03 00:23:32	2003-04-07 12:59:11	12	23	4048	36	2265	6046	2900	188.90	22	66.43	CHANGED	salhhphshSLDGthusssGsuph....lsstt...............spthhpphRppssulllGt...sTVhs-sPthssphspt.............cpPh+lVlssphchs.psp......llsps....hhhhtt...............................h.sllcpLtpp.shpslhlEGGusLtsu.hlctGLlDclplhluPhllGu..utshhsstsh.t.....hplchtphpphusslhl	.............................................................................................................................hlhhphuhSLD.....Gh.hA......t....s..s.....u...p...s...p.....a.............l.o.s.tt.........................................sc.pt..s.p...p.h...R...s....p....s....sAl.l..h..Gt.................sT..h....h.....t....-....s.....P.....t.....h....s..s...c..h..tt..............................................ppP..h..+..l..V...l..s.p..p.....h..c.....h...s......s.tp.............................................lh....p....s....s............h..h..h..h....t...t................................................................h............................................h.s.ltp.hl.p.p.....L....t...pp.....s........h........psl..h.l....EG.Gs.....p..lss....s.hl.............p.......t....s....L.....lDElhlhlu..P.h.l...l.Gs........u.....hs..h..h.s..t.....s.ht...............phphhphp.hs.....h.................................................................	0	833	1564	1990
+4153	PF05062	RICH		RICH domain	Bateman A	anon	Pfam-B_277 (release 7.7)	Domain	This presumed domain is about 85 residues in length and very rich in charged residues, hence the name RICH (Rich In CHarged residues). It is found in secreted proteins such as PspC Swiss:Q9KK19, SpsA Swiss:O33742 and IgA FC receptor Swiss:P27951 from Streptococcus agalactiae. This domain could be involved in bacterial adherence or cell wall binding.	22.00	22.00	22.00	23.70	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.73	0.72	-3.85	26	495	2009-01-15 18:05:59	2003-04-07 12:59:11	7	33	170	0	1	455	0	74.10	40	17.91	CHANGED	spppcKttptVcpalcKhLs-l...pLcKc+HTQsVsLhpKLucIKpcYLhcLss.ppc............splpph.pcsKscLDAAF-pFKK	..............ppcKutptVspYhpKhLp-h...pLc+c+HpQsVuLlpcLssIKppYL.-lssspsK..........sphppLspKspu-lDAAhpcFKK........	0	1	1	1
+4154	PF01042	Ribonuc_L-PSP	DUF10;UPF0076; ribonuc_L-PSP; 	Endoribonuclease L-PSP	Bateman A, Finn RD, Kerrison ND	anon	Pfam-B_797 (release 3.0)	Domain	Endoribonuclease active on single-stranded mRNA.  Inhibits protein synthesis by cleavage of mRNA [1].  Previously thought to inhibit protein synthesis initiation [2]. This protein may also be involved in the regulation of purine biosynthesis [3]. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase [5]. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella [4].	27.30	27.30	27.30	27.30	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.45	0.71	-4.35	30	11334	2012-10-01 19:40:00	2003-04-07 12:59:11	16	61	4115	187	3227	8930	3544	116.70	29	81.61	CHANGED	otsAP..tshusYSp.Alp..ssshlalSGQlslcs....tssclh.sssstpQscpshpNlctlLptAGsshsc......lVKsTlFlsDhsc.FAplNplaspaFsps..........PARusVpVutLP...hsshlEIEslAhh	.....................................................s..ss.a..up...ulh..........hs.s..h.l..a.h.SG...Q...l..s..hs...............................s....sp...l..........s.....s...s.....l.......p.....t.....Q.....s......c....p....s....l...c.......N.......l...c....s....l....L........p....t..A....G...s.....s...h..sc......................l...l...+...so...l......a..l......s.........D...........h..s......c......F....s....s...h.N..........p...l...a...s...p.a...Fspt................................P..A..R....o.sVt.V...s.t..Ls.....sh.hlE.I-slAh.h.............................................................	0	905	1902	2685
+4155	PF00317	Ribonuc_red_lgN	ribonucleo_red; ribonuc_red_lg; 	Ribonucleotide reductase, all-alpha domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.61	0.72	-4.18	137	5796	2009-09-10 18:18:06	2003-04-07 12:59:11	16	66	4614	118	1297	4181	2797	77.40	30	10.10	CHANGED	hthshhuhp.hL.tpcYLh..+sp..ps.........hhEsspphahRlAhslAt.p..................................................................................sphphsp....caa....phhsphpahsuoPslhNAGpsts	.....................h..hoahuhp.ph.hspYhl.......+sp.......sG....p...........hhE.s..pphhhhVAhsLup............................................................................................schphAp......cha....chhsphca.p.sATPThhNuGpsp.p....................................................................................................................	0	412	816	1098
+4156	PF02867	Ribonuc_red_lgC	ribonuc_red_lgC; 	Ribonucleotide reductase, barrel domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Family	\N	19.50	19.50	19.50	19.60	19.40	19.40	hmmbuild  -o /dev/null --hand HMM SEED	538	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.54	0.70	-5.95	136	8373	2012-10-01 23:28:04	2003-04-07 12:59:11	10	91	5010	124	2033	6508	10158	423.00	26	65.30	CHANGED	loSCFl........s.hsDol.....cuIhcshppsuhlpKtuGGlGlshop.lRspGu.lpussususGllshh+lhssssphlsQuG.pRpGAhslYLcsaHsDIh-FLs...hK.ppsuc-phR..........................................s+sl.hulhlsD..hFMc....tlcp.......stpWsLhsPpp..........................................l.phaGp.......capp.Y.ph...............................pps.......htc..plpA+cLappIhpsth-oGpPalhacDssNppssp.....p.............p.....h.........GpIpsSNLCsEIsp.tp..........................................................phusCNLuSlNLsphlpts............................................................................hshcplccslchssRhLsslIDhstaP.l.pscp............................sspcpRslGlGlhGLsshLhthtlsYsSp-AhphscplhEtltatAlcuShcLA.c.cpGsat...................sa..csStaupG....h.hchh..................................p............................................................................................WppL+ppltph.GlRNuhhhAlsPTuohS...ls.ssosulEPhhuplas+pshsst......h.hss..h.ptlpp..............h..t.ht.l.......................tsl.sh..tl.tphhth..ac.o.Aa.......-l...s.cthlchsAstptalDQu.Shslal................s..cs..ohpclpphahhAactGLKo.hYYh	.......................................................................hsSCal.........thtD..sh..............puI..h.ts.h.pp.hh.lsp.uuGlu...hthup......lRthGs.lp....s.h..p.s..usGhlsh.h.+.hhps........................sh.thssQh.............................G.h...........Rt.GA......h...........s.lalphaH.Dl.p.Fls...h+.ppp...u.pc.t.+..................................................................................................hpsh..shulh.l..s...c...hhhp.h...s.p.........stphh.L...hsP..p...........................................................................................t..h.................................thpt.Y......th...............................tp............h.h.p...pl.pA.pclaph.l.h.p..t.hpoG.Pal.hhhD......psNptss.........................................u......lp.....S..NLC..sEIh...t.............................................................p...hsCs..L.........u.........S.........hNlsthhp.......................................................................................ch.t.c.......hsphh..h....+h....L.....stl....h......D......h.....s......h..s......h...thpp............................ss...t.t+slGlGhh..shts.h...L.ht.tl.Ys....S.....p...u....h.phsphhh.hlthhshp..sS.plA..c..ct..s..s.a.......................a..p.t..o.....h..s..p....u.....h.........ph..ht..............................................t...............................................................................................WttLtt..tl..p...........Gh...h...Ns.h.Al.hP..o..sohS.....ls...........s.....s.o.s.ulc.P.hs...h.h.........+p..hpst...................................................................................................................................................................................................t...........h...h......a.p...s.sa..................ch...s.pthlchhu..hp.........p......alD.......Qu.Shsl.h................s....ph.......shppltphhhhAa.c.........h.G.....l.Ko.hYY....................................................................................................	0	708	1339	1729
+4157	PF00268	Ribonuc_red_sm	ribonuc_red; ribonuc_red_sm; 	Ribonucleotide reductase, small chain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.50	20.50	21.10	20.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.77	0.70	-5.40	13	7021	2012-10-01 21:25:29	2003-04-07 12:59:11	16	12	4393	189	1340	4104	4718	239.00	25	82.28	CHANGED	tshLpcstchF..ashcas-IhphhpcuhuspWhspElsLucDhpDhcp.LstsEppFhpalhAFhuAuDslVN.NL.schosphp.p-hcaaYs.QhuIEslHScsYShllpsLh.pDtpp+pphhsuIhspPsIpcKscWlhchls-scu.huE+llsFhhlEGIFFuuSFASIhaL+pRGLMsGls.oN-LISRDEulHTshAChlYsphh...c+Ps.chI....hclhpEAV-lEpcFlp...spsPsthhhhs...sctlpQYlcasADRLLsslGhstlassss..s.s.hs	..................................................hh.....................p....h.....p.h.app...h.s.p.aWhspc.ls..l..op.D.h.s.a.......p.........p.....L......sttE.pp.hhhpshs....hhshhD.o...l.s..p.s..h.......sl..h....h..p..h..s...c.......c..shhst..th...E.s.lHu....cuYohlhp.......s...........l............s.............s....................t...........t...............t.......h....a.......p.......h.....h...............p...................................................l...........p...c....+...........s............p...........h.............l...........................p.............h.............h.................t.............t.............t..............t...........h....................p............p...................................l.........u............s.....h.....l......Euhh....F.a.u..u....F.h.h....h.h...h............t..p.........p....s..h.....h.ss.uph.....h..chI.RDE.u.lH.h....h....h.h.t....h....h....h....p.........h....h....t....t.......p....p...........t.............p.....p....l...............hplhh...p....h....h.p.........E...h...p...asc...................h..h..s.t.......sh...........tp..h..ppalca.uspth.tlGhc..ha..sp.........s..................................................................................................................................................................	0	402	783	1091
+4158	PF00545	Ribonuclease	ribonuclease; 	ribonuclease	Bateman A	anon	SCOP	Domain	This enzyme hydrolyses RNA and oligoribonucleotides.	21.30	21.30	21.70	21.30	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.31	0.72	-3.91	80	855	2009-01-15 18:05:59	2003-04-07 12:59:11	15	18	696	335	302	839	28	88.20	33	48.99	CHANGED	LPspsp....pphshhptGhs.............sh.tpsGshFtNpEp......................hLPttssG....hYpEhsl.h.s....G.....sRGA..cRlVhusp...........uh.haaTsD.HYsoFpph	..................................................................................LPtphhpphphhptGhsh..................sh.spsGphFsNpEt......................................tLPptpsu........hY+EhsVth...s...................G......sRGu...cRllhuss.............uhhaaTsD...HYpoFpph........................	0	68	167	250
+4159	PF03631	Virul_fac_BrkB	Ribonuclease_BN;	Virulence factor BrkB	Bateman A, Eberhardt R	anon	Pfam-B_4424 (release 7.0)	Family	This family acts as a virulence factor. In Bordetella pertussis, Swiss:Q45339 is essential for resistance to complement-dependent killing by serum [1]. This family was originally predicted to be ribonuclease BN [2], but this prediction has since been shown to be incorrect [3].	25.60	25.60	25.60	25.80	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.98	0.70	-5.03	155	5654	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	3939	0	1383	3900	630	252.90	22	76.58	CHANGED	tpcchshhAuu.luaasllulhPhlhhhhulh.s........h....h...........thhpplhsh.......ltph...........................................hP.....t..sh.phlpshl.p.phh......pps.....................ttulluhuhll..........asusshhpslppuhNp....ha.............ph..pp.t+....s.........hl...ppphhshshh.l....hhsllllluhslsshhth..........................hhsh......h...hhphhph........lshhlh.hhh.hshlYphhPs.t..chphchsh.Gulluulhahlsphs...au.h.Ylsphs..sa.sshYG.ulu.ullllll..WlalsuhllLhGAplssshpptp	...............................t..pphsthAusluYaslLSlhPlLhlhhulh.u.h...hs................th.tpplh..sh......lhs.....................................................................lP........s..tss..shlpshl....p...p.l.t....sps................psu.l...l.ulshll...........aou.thhss.....lppul....Np....la......................cs...pc...pR....s.............hl...hphhhs.h....hhh..l....hhs.l.h.lh.h.ulslss..hhts.h.th..........................................hhsh..........th.......hhphl.ph......lshh.lh.hlh.ahhl.YhhlP....s...t.....+s................p.h.+t.s..l..hGuhluul.h.a...lh.p.hh...Fu..hYl.s.p.hs..........sh...sthYG...uhu..sl..l..ll..hl..WlahsshllLhGAtlsusht...h..............................	0	407	908	1180
+4160	PF00825	Ribonuclease_P		Ribonuclease P	Bateman A	anon	Pfam-B_1558 (release 2.1)	Family	\N	22.30	22.30	23.40	23.00	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.61	0.72	-4.17	141	4169	2012-10-03 01:04:38	2003-04-07 12:59:11	13	4	4132	9	899	2569	2063	107.70	28	88.95	CHANGED	h.s.+ptRLpppp-Fppla.ppup+.hts...pth..llh........htt..............................shsts..........................Rl..GlsluKKhup.AVpRNRlKRhlREsaRhppsp.ls.......uhDlVlls+.ps....ht..phshpplpp.........plpp...hhp+ht	..................................................pt.Rlpppp-Fptla....pp.u....p.....p....hu.s.....tp.h....llh...........hht......................................p......p.tps.......................................RlGloVuKK.hup.AVpRNRlKRhlRcs.hRh.t..p.p.p..ls..................shDhVl.lA+..ps...........st.....phsh..p.p.lpp.........sLp+.lhcp..t................................................	0	309	600	766
+4161	PF00445	Ribonuclease_T2	ribonuclease_T2; 	Ribonuclease T2 family	Finn RD	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.66	0.71	-4.68	116	3203	2009-01-15 18:05:59	2003-04-07 12:59:11	13	17	1368	27	551	2843	56	162.70	25	76.12	CHANGED	aD.........a.ahLs...........lpWsssaCt...................t......tpC........sttstsF.....slHGL.WPs..................p........ts.............h.sp.....C.........h........................slhsphpphWPsh.t.p.........shhpHEWpKHGTCus........................................tpsYFstshplh..pphsl.shLtpt..lhs.spstph.........shsplpsAlppss.....s..ttsslpCpp...................................hLpEltlChsps..............h...sCsp	..........................................................h.hs..pW.sshCt.....................................t........C................t.a.....TlHGL.WPs..............................................ths...t...................h..p.sCsss......hs......p.....................................................phhs.p.L...pp..hWPs...h.tsts..................phW.ctE..a.pKHGoCst.s.........................................t.tYFp.psh....phh................p.......ph......s.h.....phLtph......lhs...t..spph.......shpclt.sslppsh..........t...ttstl.pCpts.......................................................h.pl.hs.............................................................................	0	163	305	441
+4162	PF00687	Ribosomal_L1	L1; 	Ribosomal protein L1p/L10e family	Bateman A	anon	Pfam-B_115 (release 2.1)	Domain	This family includes prokaryotic L1 and eukaryotic L10.	21.70	21.70	21.80	21.80	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.64	0.70	-5.00	255	5940	2012-10-01 21:21:48	2003-04-07 12:59:11	16	17	4958	95	1878	3991	2982	212.10	38	87.56	CHANGED	lphlpp.....h.............................................t..ttcFscol-ltlsLph.........sppsspph...........psslsLP+.sht............+sh+.l...........sVhs.psp.ptp.......................pstthsuc.lluh--Ltpp........hc.pth....tcaDhhlAsschhshls.+..LGphL....us+GhhPsPh.....s.lsh.....................................s...lsptlcch+suphhhps.....+ss..slpstlGch..sh.sscclh-Nlpsllstlhph..t....hsKGh...l+slhlp..oTMusu	.........................................................................................................................................................th.hthttththht.................................................chs...psKFcp..o..V-.lulpL..sl........Ds++u..D..Q.pl................R..Gsl.........sLPp.GTG............+shRV................h.VFupG.scsctt...........................scs.A.GAD.hVGh--Lh.cp............lp.pGh......h.cFDlllAoPDh.Mt.hVG..+...LG+lL....................GP+GLM.PNPKs........GTVTh..................................................................DVscAV.c.csK.u.Gp...l.p.aRsD...........KsG.hlHssIGKl..oF...ss..........-cLhENhpuhlsslh+tK...Ps..........suKGh..Y..l+plslo.oTMGs.................................................................	0	649	1169	1576
+4163	PF00466	Ribosomal_L10	L10;	Ribosomal protein L10	Finn RD	anon	Prosite	Family	\N	22.00	22.00	22.20	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.06	0.72	-4.08	158	5754	2009-09-13 14:02:41	2003-04-07 12:59:11	15	11	4979	96	1716	3716	2281	98.80	30	50.84	CHANGED	hspppKpphl..pclpp..hlppsp.slhlsch....pGlsssphpplRppl.+ps...ssphpVsKNoLhchA...lcp.ssh................t........l.......p..s.hl...pGssulhao..pp-sss.ssKhlpca.K	......................................ppKpthV....scls-hh.......c.....s.......ut..usll..s.-h....c.GloV..sph..opLRcph.Rcs..............ssphcVs...KNTL..h++A....lct..ssh-.......................s................L.....s...c.hh....sG.Psu.ls.Fo....p-.-..ssu.sA+llpcFuK............................	0	591	1068	1434
+4165	PF00298	Ribosomal_L11	L11; 	Ribosomal protein L11, RNA binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.40	21.40	21.40	21.70	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-8.99	0.72	-3.83	171	5449	2009-09-13 02:34:37	2003-04-07 12:59:11	14	14	4897	169	1606	3179	2185	69.30	49	46.79	CHANGED	KTPPsohLL+KAAsl......c........+GSs..pP............s+pp.VGplohcQltEIAchKhs.DL....sussl-uAh+hlhGTA+SMGlpV	..............................................KTPPAu.sLLKKA.AGl.....c........+G.Su...cP.........................s+sK..VGp.lTpsQlpEI..........AcsKhs....DL.....sAs.slEuAh+hIt......GTARSMGlsV........	0	555	1012	1339
+4166	PF03946	Ribosomal_L11_N	L11; 	Ribosomal protein L11, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain of Ribosomal protein L11 adopts an  alpha/beta fold and is followed by the RNA binding C-terminal domain.	19.60	19.60	19.60	20.10	18.90	18.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.56	0.72	-4.51	167	5468	2009-01-15 18:05:59	2003-04-07 12:59:11	9	15	4889	114	1604	3175	2123	58.80	56	39.60	CHANGED	hlKLplsAGpAsPuPPlGPALGptGlNIhpFCKpFNspTpc....hp...Gh.lPVhITVas..D+SF	..........hlKLQlsAGpAsP....uPPVGPALGQ.pGl.N.....IM.cFCK...tFNA+T.pc................pt.Gh..IPVhITVYp.D+SF.................	0	555	1008	1337
+4167	PF00542	Ribosomal_L12	L12; 	Ribosomal protein L7/L12 C-terminal domain	Bateman A	anon	SCOP	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.08	0.72	-3.97	191	5164	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	4749	15	1334	3031	2145	67.20	57	51.44	CHANGED	EFDVlLsss..GspKIsVIKsV....Rs.lT.GLGLKEAK-LVEuA...Pps...lKEu..luK-EAEclKcpLE-AGA.pVElK	..................EFDVlLpuA...Gs....pKltVIKsV..........Rp.l.....T.GLGLK...EAK-LV-uA...Pp.s...lKEu..VuK.--A.EplKppLEEAGA.pVElK..........................	0	469	872	1139
+4168	PF00572	Ribosomal_L13	L13;	Ribosomal protein L13	Bateman A	anon	Prosite	Family	\N	21.10	21.10	21.30	21.70	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.59	0.71	-4.08	115	5540	2009-01-15 18:05:59	2003-04-07 12:59:11	13	13	4945	229	1626	3368	2257	124.90	46	81.05	CHANGED	WhllD..AcsplLGRLAoplAphLtGKp+s.apPt..hssGD..hVlVlNA-KlhlTG............pKh...pp+hYhph..oshsGuh+p.shpphhp.+..pPpcllc....+A......V+GMLP+..sphG+phhc+L+lYsGstHs.atst......pshtlph	..............WaVlD..Aps..ps.LGRLAoplAphLRGKpKspaT..PH..lDsGD..a.V.IVlNA-KltlTG............pKt...s.c.KhYY+H..osas.....G.GlKphoh.tchhp..+pPc+llE..........pAV+GML..P+....ssLGRthhc.KL...+..VYuGsEHs.HsAQpPpsl-.l......................................	1	568	1025	1367
+4169	PF01294	Ribosomal_L13e		Ribosomal protein L13e	Finn RD, Bateman A	anon	Prosite	Family	\N	24.90	24.90	25.90	25.00	21.80	24.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.11	0.71	-4.81	6	596	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	416	4	328	576	5	161.50	47	82.53	CHANGED	shIhpsHF+K+WQphVKTWFNQPARKsRRRtARptKAt+IuPRPsuGsLRPlV+sPTl+YNhKVRuGRGFoLEELKuAGIst+aA+TIGIAVDHRR+N+SlEuLQsNVQRLK-Y+uKLIlFPRcsp+s+ts-ussEEltpATQlpGshhPIpp.pt+plch+clocctKpapAFssLRht	.............................l.psHF+KcW......Q.......p......h.......V+saFsQPu.+K.hRRRpuR.tKAttluPR.P.s.s.......LRPlVRsP.T.l+.Y...N....p....K...lRsGRGF.oLp.ELK.uAGlst+hApTIGIuVDtRR+N...+...S.EuLp..tNVpRLK.p.Y+uK..Ll...lFP.+..+.s..p..t....s.+t.....G......D......u.....s..s...E....-.....l...t..h...A..............s.....p......h....p......s............h.hPltp......h.ht........c....h...hhloc....p.....c....thp..AatpLR.................................................................................	0	130	199	274
+4170	PF00238	Ribosomal_L14	L14; 	Ribosomal protein L14p/L23e	Finn RD	anon	Prosite	Domain	\N	23.60	23.60	24.00	23.60	22.70	23.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.89	0.71	-4.36	103	6114	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	5540	233	1569	3096	2117	119.80	57	97.21	CHANGED	MIphpohLpVuDNSGA........KplpCIp.Vl............st.p....ppphAslGDlIlloV.Kcu.................sscl+K....uplh+AVlVRs+Kt.h+.RtDGshlpF--NAsVlls..sp.s.p......PhGTRIh...GPVu+El.+..........pc.p........asKIsSLAspll	.....................................MIQ..pohLpVADNS...GA.............................................+clhCI+VL....GG.S............pR+aAslGDlIl..soV.KcA...hP.................pGpVKK....G-Vl+A..VlVRT.+Ks..hR..RsDGShI+FD-NAuVlls..sc..t.p.................PhGTRIF...GPVuRELR..........pc.p........FMKIlSLAPEVL...........................	0	520	978	1314
+4171	PF01929	Ribosomal_L14e		Ribosomal protein L14	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the eukaryotic ribosomal protein L14.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.50	0.72	-3.63	53	552	2009-01-15 18:05:59	2003-04-07 12:59:11	12	7	422	10	304	545	2	73.10	34	48.58	CHANGED	.RpshslpplpLTchplc.lsRsu+otsl+KAhcpuclppKWsposWAKKlss+cpRusLoDF-RFKlhhA.++pRsph	....Rpshsl+plpLTchtlc.ls..+uu+scsV+KAaccu.clppKWtposWAKKltspc+RuphoDF-RFKlhhsKptRp........................	1	106	170	248
+4173	PF00827	Ribosomal_L15e		Ribosomal L15	Bateman A	anon	Pfam-B_1567 (release 2.1)	Family	\N	21.70	21.70	21.90	22.50	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.07	0.71	-4.80	57	759	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	568	73	409	697	98	176.40	58	88.23	CHANGED	uhYpYlcEhW++.ppshh+hLh+.Rhhca...............Rp.sulhRlpRPTR.D+ARpLGYK.AKQGhllhRVRVRRGGR++shs+uup..+P+phGlsplps.s+slQtlAEERuuR+.hsNLcVLNSYWVGpDupYKaaEVILVDPpHsuI+sDsclsWIspssHKtRthRGLTSAG+KuRGLt.s+G.+tspKsR.sShRAs...a+	......................GAYKYlpE.La+KKQS.D.Vh.RFLhRlRsWpa..........................................RQh.sslpR.ssRPTRPDKARRLGYK.AK.QGaVlYRlRVRRGGRKRPVP.KGusYGKPpppG.VNpLKh.tRuLpulAEER.sGR+.husLR....VLNSYWVspDuoYKa..aEVILVDPtHpAIRpDPchsWIs.ps.V.HK.H.R.EhRGLTSAG+Ku.RGL..sKG.Htappsh..sS.pRtsW...........................	0	129	221	315
+4174	PF00252	Ribosomal_L16	L16;	Ribosomal protein L16p/L10e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	20.70	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.77	0.71	-4.40	141	7936	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	7072	230	1613	4271	2288	118.30	47	88.89	CHANGED	P++s...............KaRK......tp+..s+......h.pGtutt.........Gspls.aGc..............auLpuhEsu.hloucQlEAAR........huhsRhl................++...suc..........laIRl...FPcpslopKPh-sR.MGpGK.........GssctWsAhV+s.GpllFEl...s.G.l..s........phA+cAl+hAupKLPl+s..+hlt	..............................................PKRs.KaRK......pa+....G+....h.+Ghupt........................................Gspls..FGc..............auLpAl..Esu..hlTuR.QIEAAR.........hAhoRah..................................+R........sG+..........lWI+l..FPc+slTt+...shtsR.MGp..GK...................G..ss-hWVA.l.ps.G+ll.aEh.......sG.V..sc.........phA+EAhchAstKLPh+sphl.........................................	0	541	993	1334
+4175	PF01196	Ribosomal_L17		Ribosomal protein L17	Finn RD, Bateman A	anon	Prosite	Family	\N	20.20	20.20	20.50	20.50	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.29	0.72	-3.42	153	4802	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	4671	165	1229	2613	2175	101.60	51	72.16	CHANGED	hl.+NhssuLlp.............................+c+IpTThsKAKElRphsE+lIT.................lAK....c..................s.s...............................lpuRRp..shuhl.......................p...scp..................h....................................lpKLFsc........lus+Yts.RsGGYTRIlK.hu..RpG................................DsA.MAlIELV	..............................MLRNhssuLlp.............................HEpIpTThsKAKElRph.lE+..LIT...............................LuK....c.......................s..s............................................................................................lts..R..R....Ahu..hl........................+...scp..................s....................................VpKLF.s-..............luP.R.a.s.s..RsGGYTRIlK.sG...R.pG................................DsAPMAlIELV.............................................................	0	426	794	1042
+4176	PF00861	Ribosomal_L18p		Ribosomal L18p/L5e family	Bateman A	anon	Pfam-B_495 (release 3.0) & Pfam-B_741 (release 4.1)	Family	This family includes ribosomal proteins from the large subunit. This family includes L18 from bacteria and L5 from eukaryotes. It has been shown that the amino terminal 93 amino acids of Swiss:P09895 are necessary and sufficient to bind 5S rRNA in vitro [1]. Suggesting that the entire family has a function in rRNA binding.	27.80	27.80	27.90	27.90	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.24	0.71	-3.90	33	5752	2012-10-02 16:33:16	2003-04-07 12:59:11	17	13	5132	229	1513	3405	2152	116.10	39	83.74	CHANGED	scpctpp+++hhhp++hhssst+sRLlVh+SN+alhAQllssststslssASshst-Lpp..s.psshsNhsuAhtlGhLlAcRAlp........cGl.....................stlsaspsuhpYtGRVtAlAcuA+EuGLph	..............................pchtt.p.R.+tp.h.p.p.+...h......t.s...s.....t..p....sRLsVaR.Ss+cIYAQ........lIs...sssut..s..Ls..u.ASol.-.+.-lpp.......................................hs..h..ssh-AAttVGcllAcRAhp........................tGl..............................................ppVs.FD.R....u.G.a.h.Y.HG.R.VpAL...A-AAREuGLpF.....................................	0	490	947	1257
+4177	PF01245	Ribosomal_L19		Ribosomal protein L19	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	22.80	22.30	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.23	0.71	-4.29	127	4774	2009-01-15 18:05:59	2003-04-07 12:59:11	15	7	4673	153	1203	2595	2397	113.20	52	88.03	CHANGED	ts.llc...plEppph.....+..ps..lPpFcsGDTV+Vpl+lh.........E......Gs.........................+-RlQsFEGlVIu++s.t..Gl..spoFTVRKl.StGlGVERhFPlaSPtlcpI-VlR..+G............+VRRAKLYYLRs....hpGKuA.R.IKEch	......................................plIcpl-p..pQl.......+....p-.lPsF+...s..GDTVcVp.l+Vl.........E.Gs.........................+.cRlQ.sFEGV..VIu++s..t..Gl...spsFTV.RKI.S.s.G..l.G.VERsFPlHSPtl..-pIEVhR...+.G........................................c..VR..RAKLYYLRs....hpGKAA..R.IKEp.h...............................	0	415	776	1019
+4178	PF01280	Ribosomal_L19e		Ribosomal protein L19e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	29.00	29.00	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.79	0.71	-4.43	63	764	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	542	78	423	735	79	138.90	55	54.02	CHANGED	ssLphQKRLAAslLp......sGpsRVWl..DPpchs-lusAhoRpsIRcLIc-GhIhtKsh....................pupSRuRsRcpptp++.tGR++GhGpRKGspsAR.hspKphWhpRIRslRRhL+chR-stc.ID++hYRp...LYh+AKGspF+shppLhpalc.ptth.c	..............s.sL+hQKRLAAuVLp......CGcpKVWL...DPNEhsEIusANS.RpsIRK..LlKDGlII+KPs....................psHSRuRsRc...hptA++..KGRHpGhG...KR.KGTtsAR.hPp.......KhhWMRRhRlLRRLL+.+YR-ucK.ID+Hh.YHp...LYh+sKGNsFK.NKRhLhEaI++tKA-................	0	147	245	348
+4179	PF00181	Ribosomal_L2	L2;	Ribosomal Proteins L2, RNA binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	27.10	27.10	27.10	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.55	0.72	-4.01	50	6547	2012-10-03 20:18:03	2003-04-07 12:59:11	18	12	5878	241	1538	4221	2237	76.40	54	28.40	CHANGED	GRNsp.G+ITsR++GGGpKp.tYRhIDFpR.spts......l.uhVhsI-YDPsRsAhIALlpats...Gccp.....YILuspGLplGsplhu	.............................GRNsp..G+ITs.RH.pGG.G.HK+.tYRlIDFKR..sK.cs.............IsupVtpI....EYDPNR...oA.pIALl.p.YtD.....GEKR...........................YIlAPc.GlpsGsplh...................................	0	516	966	1289
+4180	PF00453	Ribosomal_L20	L20;	Ribosomal protein L20	Finn RD	anon	Prosite	Family	\N	24.10	24.10	25.20	25.00	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.37	0.72	-4.12	129	5432	2009-01-15 18:05:59	2003-04-07 12:59:11	13	10	5206	158	1102	2738	2165	104.60	52	89.30	CHANGED	sRV...KpG..sssRpR+KKlLKhAKGahGs+uphaRsApppVh+AhpYAYRDR+p+KR-FRpLWIsRINAAsRtpG...l..oYSpFlpuL+pusIp......lNRKhLA-lAlpDspuFspl	...................hRVKpG..ssuR.tR+K.KlLKh.AKGYhGu+pplaRsApptV.h+uhpYAYRDRRp+KRsFRpLWIsRINAAARtsG...............l...........SYS..+hhpGLK+A...sl-......lsRKhL.A-lAlpDtsAFssl....................................	0	386	724	933
+4181	PF01157	Ribosomal_L21e	L21e;	Ribosomal protein L21e	Finn RD, Bateman A	anon	Prosite	Family	\N	21.60	21.60	22.00	23.90	21.10	21.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.14	0.72	-4.20	6	896	2012-10-01 20:16:17	2003-04-07 12:59:11	13	6	529	75	505	859	81	94.60	51	64.65	CHANGED	spScGhRRtTRhhFpRcFRcHGlssloThl+pYKcGDhVcIKssuSlQKGMPHKtaHG+TGpVaNVs.uulGlhlNKcVpsphl.KRIplpsEHI+.Sc	...........po+GhRptTRhhFuR.sFR++.G..s.l.P.Lu.TYh..+hYKhGD....hVDIK...s........sGuVQK.GM.P.H.KhYHGKTG.cVaNV..Tpc.AVGlll.NKpVps....+hlt.KRIs.VRlEHl+cS.................................	0	137	228	326
+4182	PF00829	Ribosomal_L21p		Ribosomal prokaryotic L21 protein	Bateman A	anon	Pfam-B_1297 (release 2.1)	Family	\N	21.10	21.10	21.10	21.10	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.94	0.72	-3.86	67	4725	2009-01-15 18:05:59	2003-04-07 12:59:11	16	12	4593	156	1157	2545	2044	95.10	44	82.00	CHANGED	MYAllcoGGKQa+VptGchlhlEKl.ss.csGsplphscVLhluss.tpsplGpPhlcG..ApVpAcVlpc.s+ucKlhlaKa+p+Kph+++pGHRQ.aTcl	...................................MYAllco.GGK..Qa+VptGphlh.l.E......KL......ss......c......s............G.......pp.lpF..s..c..VLhVuss.......p.lplGs.P.h..V..sG...ApVsAc.Vlpp....G+.u.c..KlhlaKa+.p.+Kp.h.++.+pG.HRQ.aTcl....................	0	416	764	986
+4183	PF00237	Ribosomal_L22	L22; 	Ribosomal protein L22p/L17e	Finn RD	anon	Prosite	Domain	This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.	20.10	20.10	20.30	20.40	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.24	0.72	-4.09	126	6446	2009-01-15 18:05:59	2003-04-07 12:59:11	14	18	5594	236	1745	3781	2204	106.90	41	78.62	CHANGED	Aht..+tl+lSscKsphlschIRGpslpcAlshLchs....................................................sc+uuphlhKlLcSAhANA..p.....psps.h-.s-pLhlpclhlscGsphK.RhpPRApGRAs.lpKcssHlpllls-	.....................................Aht+tlRhSs..pK.s.RhVsDhIR..G......+pls..cAl.slLpas.........................................................P.c.+.A.Athl....tK.lL..pSAl.A.NA...E.............................pNtu...hD....hc....s..LhV..........scsaVs.c.G.s........s.......h.K..Rh.pP..RA....+G...RAstIp..KcTuHITllVs.......................................................	0	576	1053	1415
+4184	PF01776	Ribosomal_L22e		Ribosomal L22e protein family	Bateman A	anon	PSI-BLAST P56628	Family	\N	23.30	23.30	23.70	24.20	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.55	0.71	-4.06	35	584	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	350	6	314	534	5	110.50	52	81.65	CHANGED	p.KK...ssh....KFslDCopPsEDs.IhD...lusF......E+aL+-RIKVsGK...........sGNL.G.....ssVsls+p.csKlsVsoclsFSKRYLKYL........TKKYLKKssLRDWLRVVAo..sKssYELRYFpl.spsp-----	......................t.pK.sh+FslDCopPVEDs.IhD...su.sF......EpFLp-RIKV.s.G.K...........sGNL..G......s.s.V.sl.p+p..KsKIs..Vs.S..-......h.s...F.S.KRYLKYL...........TKKY.LKKps......LRDWLRVVA.s..sK..s..sYELRYFpI.sp---E--.c......................	0	100	168	246
+4185	PF00276	Ribosomal_L23	L23;	Ribosomal protein L23	Finn RD	anon	Prosite	Family	\N	21.10	21.10	21.20	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.83	0.72	-4.04	12	6180	2012-10-02 20:46:34	2003-04-07 12:59:11	15	12	5417	233	1734	3501	2091	88.90	36	80.46	CHANGED	hcll+hPllT-K.shphhcp.NphsFhVshcusKhclKcslcplasV+VhsVNThlh.sKhhR...Gph..hhp..hKKAhlpLp.cs.pthshhsch	.....................................h.cllhtPll.TEK..uhth............h.........-.c.......s......ph.sFpVsh...cA.sKspIKpAVE.pl.F...s.....V..c..VtsVN.T.hs...........h....p....u.....K.....h........K.......R........hG.....p........h.....h....G......p............p..t..c...hKKAhV.oLp.tG..ppl.h...t..................................................	0	536	997	1350
+4186	PF03939	Ribosomal_L23eN		Ribosomal protein L23, N-terminal domain	Finn RD	anon	DOMO_DM01622	Family	The N-terminal domain appears to be specific to the  eukaryotic ribosomal proteins L25, L23, and L23a.	20.50	20.50	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.78	0.72	-3.94	47	612	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	318	8	359	542	1	56.00	52	33.22	CHANGED	tss..ts+AtpA.............pKAllKG..spu.........p+p.+KlRTSspF+..................RPKTL+hsRsPKYPR+SsPcp	.........................................................................................s.pspuKAhKA........pKAVlKG...sau......................+Kt..+K.lRTSsTF+..................RPKTL+LpR.pPKYPRKSsP+..............	0	80	141	211
+4187	PF01246	Ribosomal_L24e		Ribosomal protein L24e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.80	20.80	20.80	20.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.37	0.72	-4.12	7	1060	2012-10-03 05:12:49	2003-04-07 12:59:11	15	10	541	76	653	956	68	67.60	43	44.21	CHANGED	h+schCpFsGtcIYPG+GhhFlRsDupVFhFtsSKCcp.F+.++pPR+lsWTshYR+pHtKs.stEstccp	...............M+hchCtFsutpIYPG+Ghh.aV.....R....sD.uKlFpFp.sSKC.c.ps.F.p.h+....+NPRKlpWTthaR+tptKths.c......................................	0	228	377	537
+4188	PF01386	Ribosomal_L25p		Ribosomal L25p family	Bateman A	anon	[1]	Domain	Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis Swiss:P14194, which is induced by stress.	21.50	21.50	21.60	21.90	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.86	0.72	-3.86	184	3556	2009-01-15 18:05:59	2003-04-07 12:59:11	14	2	3478	158	851	2159	2048	87.40	33	49.38	CHANGED	LpAphRp....p..hG.KuuuR+LR+.pGtlPAVlYGts.pc.s.....hslslstpcltchl....ptshtssl.lsLp.lc....G......pp.tpsll+-lQhcPlps.plhHlDF	............lpuphRp.....p..hG..KuAuR+LRc.sG.plPAllYGts..pp..s........................lslplcppclhphlt...ptt...h...h....s.s.l.lsl.s.l.c.G...........cp.hp.Vllp-lQhcPh.+s.plhHlDF................	0	295	572	730
+4189	PF01016	Ribosomal_L27		Ribosomal L27 protein	Bateman A	anon	Pfam-B_1340 (release 3.0)	Family	\N	20.50	20.50	20.80	21.10	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.54	0.72	-4.19	88	4787	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	4661	166	1215	2396	1851	80.80	60	81.70	CHANGED	AHKKuuG.So+N.GRDSpuKRLGVK+aGGphVpuGsIIlRQRGT+hHPGpNVGhG+DaTLFALh-GhVcFppp......pp...++hVsVh	...................AHKKuuG.ST+N.GRD.SpuKRLGVK+aG...GphVpAGsIIlRQ.R.............G.............T...+hHPG.sN.....VGhG.+D.cT....LFAhsDGhV+FcpK........s+s...RKhVSV..........................	1	418	783	1027
+4190	PF01777	Ribosomal_L27e		Ribosomal L27e protein family	Finn RD, Bateman A	anon	PSI-BLAST P51419	Family	The N-terminal region of the eukaryotic ribosomal L27 has the KOW motif.  C-terminal region is represented by this family. 	22.60	22.60	23.50	22.90	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.14	0.72	-3.86	42	533	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	381	6	297	498	5	82.70	49	58.62	CHANGED	KVTK+MuK++ltKRS+lKPFlKllNYNHLMPTRYol.Dl..t.Ksl......ls..p-sh+-ssp+ccA++pl+ttFE...ERa..........KsGKN+WFF.pKLRF	...................KVT+pMuKKKlsKRSK.lKsF..lKllNYNHLMPTR..........Yol.Dl......Ksl........ls..p-sh+-ssp..+..c....cA++p.....sKtt.hEERY............csGKN+WFF.pKLRF....................................................	0	107	164	238
+4191	PF00830	Ribosomal_L28		Ribosomal L28 family	Bateman A	anon	Pfam-B_1561 (release 2.1)	Family	The ribosomal 28 family includes L28 proteins from bacteria and chloroplasts.  The L24 protein from yeast Swiss:P36525 also contains a region of similarity to prokaryotic L28 proteins.  L24 from yeast is also found in the large ribosomal subunit	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.65	0.72	-4.14	114	4841	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	4485	146	1176	2313	1891	59.80	39	73.86	CHANGED	+c.CplTGKpshh.GNsVS.............H..upp......+T+RpatPNLppp+lassp.schl+l+los+sL+o..lcKpG	........................+hCplTG.Kpshs.GNs.hS..............H..upN.............pTKR+ahPNLpphRhhl.-...s...+h.h.+.l..pVSs+uL+s...lpt..............	0	402	770	1005
+4192	PF01778	Ribosomal_L28e		Ribosomal L28e protein family	Bateman A	anon	PSI-BLAST P17702	Family	\N	21.60	21.60	22.10	22.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.56	0.71	-3.69	67	772	2009-01-15 18:05:59	2003-04-07 12:59:11	12	8	384	5	475	736	4	113.20	30	53.54	CHANGED	LhWpll..+psss.FhhKpp.......stpFop-shNlsshsoh+asG...................................Lsss+slsl..pss..sG....tlhlshKps...cpsppPu.+thpp.....hplsp..sh+cuhcplcphhpt.....aRt-Ltpt...uhpRhot.............lhpst	...........llWpll..pps..s.F...h.lKp.p...........sppFs+.......p.hNlsulsshp.ss...................................LuNs.+hssl...pts...pG..................slhlh.h.Kph...ccsp..tPu...+h....ap+..............splsc...shc+slpplccplth...........apt.Lt.pt.....shpRhotlhp..h......................	0	169	262	389
+4193	PF00831	Ribosomal_L29		Ribosomal L29 protein	Bateman A	anon	Pfam-B_1296 (release 2.1)	Family	\N	24.50	24.50	24.50	24.60	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.53	0.72	-4.28	156	5085	2012-10-02 11:59:50	2003-04-07 12:59:11	18	7	4872	242	1354	2614	1785	57.70	41	77.08	CHANGED	spElRphos.cELpcclt-L+pELhpLRhppus.Gpl..ppsscl+plR+sIARlhTlls-+	................hpELRphos.-ELppc...LtpL...KcELFsLR..hQtAT...GQL..ppsscl+pVR+sIARl+TllpE+.............	0	475	879	1141
+4194	PF01779	Ribosomal_L29e		Ribosomal L29e protein family	Bateman A	anon	PSI-BLAST Q24154	Family	\N	20.70	20.70	21.30	25.30	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.16	0.72	-4.09	30	523	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	333	6	267	471	3	39.40	67	40.99	CHANGED	KSKNHTsHNQ.N+KAHRNGIKKP+c..pRa.ShKGhDsKFL+N	.........KSKNHTsHNQ.o+KsHRNG.I.KKP+s...pRY.....t.SLK..G.lDPK..FLRN...........	0	77	129	188
+4195	PF03947	Ribosomal_L2_C	L2;	Ribosomal Proteins L2, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	21.50	21.50	21.70	21.90	21.10	21.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.54	0.71	-4.34	58	6875	2012-10-01 20:16:17	2003-04-07 12:59:11	13	12	6045	240	1601	4450	2557	124.70	56	47.82	CHANGED	lchGNslPLppIPlGThlHNlEhpPGcGGplsRoAGohAplluKps..p.ashl+LPSGEh.+hlpppC....hATIGtVuNhsppphslG.KAG+sRWhGh.....RPpVRGVAMNPVDHPHGGGEG+sthGR.psVoPWGpP	..............................IKsGNsLPLp....sIPlGTslHNlEl+P........G..+GG.......Q.lARoA..........Gs.AQ..........llu.......+...........-G................pYsplRLsSGEh.Rhl.ssC.........+A........TlGpVGNsp.+.t..h..slG.KAGpsRWhGh.....................RP.sVRGss.MNPVDHPHGG.GEG+ss..h....G..R....p...PsoPWGh...................................	0	533	1001	1341
+4196	PF00297	Ribosomal_L3	L3;	Ribosomal protein L3	Finn RD	anon	Prosite	Family	\N	26.50	26.50	26.80	26.80	26.40	25.20	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.72	0.70	-4.99	13	5795	2009-09-16 22:34:17	2003-04-07 12:59:11	17	16	5080	235	1672	3675	2404	198.80	40	84.21	CHANGED	KsGMTplh.........scs.tss.sVTllEssPssVltlpshs...............................................s-GhpulplshpphKcppsshplluHhphtsss....tKtalhEhplssu..........cpaE..pslsV.slFppsEhlDVtGlTKGKGFpGshKRWGhp+hPtpHupu..+R+lGslGA.hcPuRVhhosthsGphG.c+RT.hNhKIh+lss......................................csshlhlKGuVPGs+pplVpl+	..........................................................................................KlGMTplF.............scs.G.hlP.VTVl-ss.s...shVsQ..l+oh-................................................................................................................................sD...G.Y...p....A..l..Q..l...s...h...s....s.....h........+........t.....p..p........s........s..K...P.....t........G...H......htKAss...................t..................spRhlh.E...h+.hsss............................pthp.l.Gp..plsl.-l.FtsGc.hVD.VoGsSKGKGFt.........GslKRasFpt.t.s.t...o.H.G.sph....HR.psGSl....Gs...tts..P....uR.VFKG++MAG+MG.sc+..VT..l.QNLcV.l.+VDs...............................................................EcsllLlKG.u.V.PGsptuhlhl+...................................	0	600	1058	1399
+4197	PF00327	Ribosomal_L30	L30;	Ribosomal protein L30p/L7e	Finn RD	anon	Prosite	Domain	This family includes prokaryotic L30 and eukaryotic L7.	22.40	22.40	22.40	22.50	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.32	0.72	-4.37	115	5033	2009-01-15 18:05:59	2003-04-07 12:59:11	15	10	4388	240	1490	2792	891	51.90	37	54.41	CHANGED	tlplshl+u.hl...utt.cp+pslcsLGL++lspsVhhcsoP.slp.........GMl.pcVpaLV	.....................l+lThh+S.sI....Gp..pp+tT....l.puLGL+...+lspo...Vhh.c.D.s.P.ulR.............GMlppVpahV....................	0	474	898	1215
+4198	PF01197	Ribosomal_L31		Ribosomal protein L31	Finn RD, Bateman A	anon	Prosite	Family	\N	21.80	21.80	22.20	22.70	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.37	0.72	-3.98	163	5588	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	4410	108	1124	2737	1977	73.20	45	92.06	CHANGED	M.KpsIHPc.Yppl.shpss.sGspFhopSTh...............pt..l...pl-lsSps..HPFYTG.c.p+h.lDosGRV-+Fp++a.utt	..................................M.Kp..sIHPc.Y+.p.l.sh.pso.sG..ptFhotSTh.................shshl...pl-lsSps..HPFYTG...+....Q+h..ls.s.sGRV-+Fp+RaGh.h...............	0	368	722	947
+4199	PF01198	Ribosomal_L31e		Ribosomal protein L31e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	26.10	25.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.60	0.72	-4.31	59	847	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	531	78	443	768	76	81.00	49	67.39	CHANGED	pcllTR-hTIsL++th+tsshKKRAP+AlKpIRcFsp+pMtTc..DVRlDscLNctlWu+GI+ssPtRlRVRluR+cs-p-suppc	.....................................-VVTREYTIs.lHK+.lHGl..............sFK.KRAPR.AlKEI+KFAtKpMGTs..DV.RlD.s.cLNKtlWu+GI....+.s.VPhRl.RVRloR+.RN--.E-u.p......................	0	137	224	315
+4200	PF01655	Ribosomal_L32e		Ribosomal protein L32	Bateman A	anon	Pfam-B_1346 (release 4.1)	Family	This family includes ribosomal protein L32 from eukaryotes and archaebacteria.	25.00	25.00	26.20	25.80	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.22	0.72	-4.01	75	903	2009-01-15 18:05:59	2003-04-07 12:59:11	13	11	637	76	442	805	68	103.50	53	78.33	CHANGED	+ph+FpRapSc+ap.Rlss..sWRKP+G.lDs+lRR+a+Gphh...hPpIGYGSs+csRtlhPS..GacchLVpNlc-L-hL......pscshAucIApsVuu+KRhpIl.c+ApcLul+VhNs	..................+sK+FhRHpSDRah.+lpp..sWRKP+G.IDsRVRR.RF..K.Gp.hh...MPsIGYGSsK+TR......HhlPo..GF+..+F.LVHNV.+-LEhL....hM.pN.+sasAE......IAHsVSu+KRptIl.cRA.tpLul+VsN.........................	0	133	228	323
+4201	PF01783	Ribosomal_L32p		Ribosomal L32p protein family	Bateman A	anon	PSI-BLAST P31558	Family	\N	21.20	21.20	21.20	21.30	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.89	0.72	-3.79	171	5348	2012-10-03 10:42:43	2003-04-07 12:59:11	18	14	4994	161	1126	2495	1357	53.90	34	82.85	CHANGED	AVPK++sS+o++chRRup.h.....plpss.sl................s.ssp..su.phplsHplssss.G..aYps+plhpt	...............AVPp++sS+o..++shR.Ro..+.h......pl.sss..sl................s.s.s..sG..-.....h.+.lsH...+...lshs...G.....hYpG+plh.............................................	0	378	726	946
+4202	PF00471	Ribosomal_L33	L33; 	Ribosomal protein L33	Finn RD	anon	Prosite	Family	\N	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.48	0.72	-3.72	117	6317	2009-01-15 18:05:59	2003-04-07 12:59:11	15	6	4846	154	1214	2452	978	49.00	45	90.31	CHANGED	R...htlpLt..Cop..............sssppYsTsKN++spsc+LEl+KaCs........hspKHTlH+EtK	....................R.pIpLt..sot........................sss+pYhTsK..N..+..R..N..s.P-RLE..lKKasP........hs+KHsla+EsK............	0	417	791	1027
+4203	PF00468	Ribosomal_L34	L34; 	Ribosomal protein L34	Finn RD	anon	Prosite	Family	\N	25.00	25.00	30.30	33.30	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.21	0.72	-4.28	143	4214	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	4149	154	1033	1670	249	43.90	63	86.81	CHANGED	hKR.TaQPoph+RpRsHGFRuRMp.T+sGRcVLppRRtKGR+cLos	............MKR.Ta.Q.Poph.+RpRsHGFRsRMu.T+sGRpVLApRRsKGRKpLos....	0	353	675	875
+4204	PF01199	Ribosomal_L34e		Ribosomal protein L34e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.60	20.60	21.50	21.40	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.21	0.72	-3.76	52	630	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	462	6	352	585	12	89.50	47	77.16	CHANGED	Ms...+lhh....++R.sYpT+SN+++hs+TPG..G+lVhpahKKpsshP+..CupCtph..LpGl.thRstchp+..hsKpp+pVsRsYGGshCspCl+c+Il+AFL	...............Ms..p.RlTaRRR..sYsT+SN+pRll+T.PG..G+LVh.ahKKpussPK..CGs..C.st+..LpGl.......slRPp.chtp..lS..+scKoVsRsYGGshCupCV+-..R..IlRAFL................................................	0	122	194	280
+4205	PF01247	Ribosomal_L35Ae		Ribosomal protein L35Ae	Finn RD, Bateman A	anon	Prosite	Family	\N	21.00	21.00	21.00	29.10	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.25	0.72	-4.21	44	533	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	374	8	317	528	13	93.90	51	77.29	CHANGED	LY..sKulahGY+Rup+NQppssuLlKIEGVss+c-upFYlGKRlsYVY+uppppp.........t.o+hRsI.WGKloRsHGNSG....sVRA+F+.pNLPspAh.GpplRlh	....................LasKuhahGY+Ruh+NQp.pT.uLlKIEGVps+c-sp.FYlGKRs.AYVY+A+pp..pp.....................so+hRsI.WGKVTRsHGN..SG....sVRAKF+.pNLPs+uhGtplRVh....................	0	112	169	243
+4206	PF01632	Ribosomal_L35p		Ribosomal protein L35	Bateman A	anon	Pfam-B_1156 (release 4.1)	Family	\N	22.20	22.20	22.30	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.95	0.72	-4.07	22	4520	2009-01-15 18:05:59	2003-04-07 12:59:11	14	1	4430	154	1091	2113	1842	60.70	44	86.05	CHANGED	sKhKTp+uusKRFKtTusG.thhRc+As+pHlLtKKosp+K.R+Lcppshlsps-sctlcthL	............PKhKT++uAAKRFKhTuoG.plK.Rp+Ahp..pH....lLs..+..K.....osKpK.R.....pLR.tssh.V..s.p.uDh.cpl+phL..............................	0	376	708	922
+4207	PF00444	Ribosomal_L36	L36;	Ribosomal protein L36	Finn RD	anon	Prosite	Domain	\N	21.70	21.70	22.00	21.80	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.90	0.72	-3.97	108	5148	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	4407	121	1073	1688	153	38.20	58	90.83	CHANGED	MKVRuSl...K+hCcsC+llRR+......G+lhVIC.ssP+HKQRQG	......MKVRsSV...Kp...h.C..ccC+ll.+R+......G+lhVIC....sNP+HKQ.RQG...	0	360	686	906
+4208	PF01158	Ribosomal_L36e	L36e; 	Ribosomal protein L36e	Finn RD, Bateman A	anon	Prosite	Family	\N	19.40	19.40	19.90	20.30	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.33	0.72	-4.06	39	534	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	365	6	288	505	4	94.80	52	79.12	CHANGED	ss+...slsVG..LNKGHpsT+...........p.ppsRsS++...KGhhoK+s+hVR-llREVsGaAPYE+RshELLKluKD...KRALKFtKKRLGTHhRAK+KREEhpslltt..RKt	..................h.+.slsVG..LNKGHp.sT+...............ps.tsR.S+p............KG.thoK+o+FVR.-llREVsG.aAPYE+Rs.hELLKloKD...KRALKhhKK.R.L..GTHhRAK+K.+EEhsslltt.R+.....................	1	97	156	230
+4209	PF01780	Ribosomal_L37ae		Ribosomal L37ae protein family	Bateman A	anon	PSI-BLAST P54051	Family	This ribosomal protein is found in archaebacteria and eukaryotes. It contains four conserved cysteine residues that may bind to zinc.	21.90	21.90	21.90	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.22	0.72	-4.12	55	636	2012-10-03 10:42:43	2003-04-07 12:59:11	14	4	512	74	373	557	67	86.00	53	92.54	CHANGED	s+RTKKVGlsG+aGsRYGuoLRKpV+clElpQ+u+YsCsaCG+pu.VKRpusGIWpC..+pCscshAGGAYsssTsuutos+psIcRl.cchp-	..............KRTKKV.GIsGKYGTRYGASLRKhVKKhEloQ...Hu+YsC..sFCGKss.lKRp.uVGI.WpC..cpCt..+slAGGAashsTsuAsol+S.slRRL.+-...p...................	0	127	212	300
+4210	PF01781	Ribosomal_L38e		Ribosomal L38e protein family	Bateman A	anon	PSI-BLAST P23411	Family	\N	21.00	21.00	21.20	21.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.30	0.72	-4.22	26	458	2009-09-10 15:39:13	2003-04-07 12:59:11	13	5	349	6	280	401	2	68.40	56	82.79	CHANGED	P+pIpDIK-FLphsR.RpDA+...Sl+IK......Kssps.....TKFKVRCS+YLYTLVVsDpcKAcKLcQSLPPsLplp-l	....................................P+pIp-IK-FLhhAR..R..KD.A+.....SV+IK...........KNpcs............lKFKVRCSRYLYTLVlp.Dp-KA-K.LKQSLPPuLpVp-l...............	1	97	156	225
+4211	PF00832	Ribosomal_L39		Ribosomal L39 protein	Bateman A	anon	Pfam-B_1293 (release 2.1)	Family	\N	21.60	21.60	21.80	24.60	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.05	0.72	-4.49	44	553	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	446	76	309	534	23	42.30	60	75.51	CHANGED	pKhRLAKAhKQNR.lPtWlhlKTsp+lchNsKRRaWRRo+LKl	...hKp+LAKttKQNRPlPpWlRh+TsNpIRYNuKRRHWRRTKLt........	0	101	179	245
+4212	PF00573	Ribosomal_L4	L1e; Ribosomal_L1e;	Ribosomal protein L4/L1 family	Bateman A	anon	Prosite	Family	This family includes Ribosomal L4/L1 from eukaryotes and archaebacteria and L4 from eubacteria. L4 from yeast has been shown to bind rRNA [1].	20.80	20.80	21.20	20.80	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.01	0.71	-4.91	165	5579	2009-01-15 18:05:59	2003-04-07 12:59:11	17	12	4937	231	1620	3471	2695	191.40	36	83.57	CHANGED	lpL...ssplFsh.....ph.ppsll+psVht.hus.................pRpGTtssK.sRu-VsG....us+KPa+QKGTGpARtGoh+..............uPha+GGGhsaGP+P.R.sash.+lN+K..........h++hAl+oALotpsps.splhll-.....s..h.p..lp............psK......................TKphhphLps.................lph............................p.............psLllss........p................sp.................................slhhuuRNlssV.clhsspp.....................lNlhcllptcp....lllTcsAlcp.lpch	........................................pLscslFu.h..-.h...Nps..llapsVhs.hAs...........tRQGT+.ssK..sR....u-..VoG....uG.+...KPa+QKGTG.RA....RpGolR..............uP.aRGGG.h.sF.uPpP..R..sa.u..h.KlsKK.........................h+RhAl+SsLSp.....pspp.sp.l.hll-.............sh..s...hp..........................sPK......................................TKp..h.sph..L.ps......................lsl.........................................c...cs..L.llss...................c...............hc..c.........................................................slh...LuuRN..l....s..s.....V....cVhs..s.s.s.....................lsshsllstcc....llhTpsAlcplEE.h.........................................................................	0	573	1032	1366
+4213	PF01020	Ribosomal_L40e		Ribosomal L40e family	Bateman A	anon	Pfam-B_884 (release 3.0)	Family	Bovine L40 has been identified as a secondary RNA binding protein [1]. L40 is fused to a ubiquitin protein [2].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.75	0.72	-4.37	3	580	2009-09-11 04:53:38	2003-04-07 12:59:11	12	14	450	7	314	466	8	48.80	64	40.21	CHANGED	VMEPTLsALAKKYNCEKKVCR+CYARLPPRATNCRKKKCGHSNsLRhKKKLK	.............l.IEPSLp.LApKYNC-KhICRKCYARL.PRAoNCRK+.KCGHoNpLRPKKKlK.........	0	93	167	254
+4214	PF05162	Ribosomal_L41		Ribosomal protein L41	Wood V	anon	Wood V	Family	\N	22.30	22.30	23.10	23.10	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.82	0.72	-7.02	0.72	-4.27	3	137	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	118	2	61	85	2	24.80	85	51.88	CHANGED	MRuKWKKKRMRRLKRKRRKMRQRSK	..MRAKWRKKRhRRLKRKRRKMRtRSK....	0	22	33	49
+4215	PF00935	Ribosomal_L44	L44;	Ribosomal protein L44	Finn RD, Bateman A	anon	Pfam-B_1065 (release 3.0)	Family	\N	25.00	25.00	26.30	28.60	23.70	22.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.73	0.72	-3.97	44	678	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	513	75	382	617	73	76.10	56	65.83	CHANGED	pHo.HcVspYK.pGKtothupGcRRacR..+ppGaGGpp+Pl.c+.uKs......TKKlsL+hcCspC+ptphpsh..hRsK+FElsp	..........KHp.HKVTQYK..pGKsShhAQ.GK.RRYDR..KQsGYGGQTKPlF+KKAKT......TKKlVLRLEC..s..p..C..+p+pp.h.sl..KRCKHFELG.G..............	0	123	209	303
+4216	PF00281	Ribosomal_L5	L5;	Ribosomal protein L5	Finn RD	anon	Prosite	Domain	\N	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.57	0.72	-4.18	17	5354	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	5030	233	1428	3077	2087	56.40	51	30.97	CHANGED	Nh..MclP+..lpKlVlNhGlGEuspc...LppuhptLptIoGQKPlhT+A++olusF+lR	................................slMplP+..l-KIVlNMGVG...E.Ass..c.pKhL......-.sA..........s.p-.....Ls.......hIo.GQKPl......lTK.A+...KSlAuFKlR.................	0	489	916	1202
+4217	PF00673	Ribosomal_L5_C	L5_C;	ribosomal L5P family C-terminus	Bateman A	anon	Pfam-B_69 (release 2.1)	Domain	This region is found associated with Pfam:PF00281.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.12	0.72	-4.25	133	5473	2009-01-15 18:05:59	2003-04-07 12:59:11	16	5	5067	233	1480	3191	2159	95.30	53	52.03	CHANGED	sIGs.+VTLR.Gc+MacFL-.+llslslPRl+DF+GlsspuFDupG.NashGl..cEpllFPElc..Y...Dth.p..lhGMDlsll...............ToAcssp..........cu+.LLcthuhPFh	...........PIGsKVTLR.G-.RM.a.EFL-.+LlsluLPRl..R....DF.RGl........s........s........+u.F....D....G........R........G.N.YohGl..+EQl..I..F.PEI-.....YD+l-+..l..RGhDIslV.................................TTA...p...oD-..........EuRtLLpthuhPF.t...............................................	0	504	944	1249
+4218	PF01159	Ribosomal_L6e	L6e; 	Ribosomal protein L6e 	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	22.20	22.40	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.43	0.72	-3.81	46	607	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	377	8	327	549	4	102.90	43	45.55	CHANGED	lNGVPLRRVsQpYVIATST.KVDlusVc..........l.cc..lsD....sYFp+p+....pcp+......Ks.Es.shFs..pctp.cppsscpR+s.......D.....QKsVDssllsuIKKp.Pp...LppYLuupFoL+suphPHchpF	...........................................................lNuVPLRRlsQpYVIATST.KlDlSu..Vc..........l.c.+..lsD....tYFp+c+..........p+t+.........+p..Eu.-hFp.......pcpc...+h.....plsppRKt..........D..............QKsVDptllstIKt.h.P.......LpsYLtuhFuLps.G....hPHchhF.............................................	0	110	171	254
+4219	PF03868	Ribosomal_L6e_N		Ribosomal protein L6, N-terminal domain	Finn RD	anon	DOMO:DM07096;	Domain	\N	25.00	25.00	25.80	25.80	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.95	0.72	-4.08	19	310	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	167	1	127	268	0	59.80	38	24.76	CHANGED	hhspK...tpt+sSRNPsLsRGIGRYSRSAMYpR+uLYKhK...sKsstsh......KccsttsssKsl	..................ht...tK....tp.+ssRNssLs.+GIuRYSRStMYp++..A.lY+hK....hpsstst.......Kp+s.sslsKs...............................	0	38	57	81
+4220	PF01248	Ribosomal_L7Ae		Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	Bateman A, Finn RD	anon	Prosite	Domain	This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118 [1].	20.40	20.40	20.50	20.50	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.83	0.72	-4.47	54	5260	2012-10-10 14:40:03	2003-04-07 12:59:11	21	25	2077	176	2228	3938	199	91.70	23	56.33	CHANGED	pplpphlphuhcssp.lthGhpcssKslcps..cA+LlllApssss.phhp......hl.hlsp..cpslsh..hhls..uttcLGphsGhphh.ssuhulhssGsuphlh	...........................p..h.phlt.h.uh..cstp...lhhGhpp.......shK....s..lcps.............pup...........L..V.llA......p....Dss........s..........phht.........................l..shsp..........ctslP.h....h.h.lt.....s.p........t....cLGpssGpph......ssslulhs.t.t....h.................................	3	763	1239	1762
+4221	PF03948	Ribosomal_L9_C		Ribosomal protein L9, C-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.56	0.72	-3.90	147	4474	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	4407	129	996	2561	2059	87.20	34	56.38	CHANGED	hp....pA..pplAppLp..shs..lpltt+uG-.sG+LFGSVTspDIA-ulppp..GhclD++clpl.sp..s.IKslGpaplsl+LHs-Vsuplplp..Vssp	.........................................h.spApthtppLp....shp..VplssK.u......G..-....sG..+.L..F.G.....Slos+-IA-Alppt....G.......lc.......l-K+cl......cLsp...s.I+.slGpapVsV..+L.Hs.-VpuplpVpVst.................	0	346	671	852
+4222	PF01281	Ribosomal_L9_N	Ribosomal_L9; 	Ribosomal protein L9, N-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.04	0.72	-4.72	157	4600	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	4492	134	1130	2731	1908	48.00	47	29.79	CHANGED	McVILhccVpsLGctG-lVcVpsGYARNaLlPpshAhhATpts...lcph....c	................McVILlccVtsL..G.p..hG-lVpV+sGYARN.FLlPpGhAl.ATptslpthc....................	0	398	748	961
+4224	PF00338	Ribosomal_S10	S10;	Ribosomal protein S10p/S20e	Bateman A, Finn RD	anon	Prosite	Family	This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.	21.20	21.20	21.90	21.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.11	0.72	-4.14	193	5735	2009-01-15 18:05:59	2003-04-07 12:59:11	17	13	5081	211	1645	2828	1995	96.50	50	83.97	CHANGED	lRIcLcua-t..phL-pssppIlcsu......ccp.uhplpGPlsLPT+p.pphTlh+SPasp.Kco+-p.FEhRsHKRll-l................pssscsl..ctL.....h.plpl....PsGVsl-lpl	..................................................IRIRLKAaDH..+llDpostcIV-TA.................KRT..GAp....V.p...G.....P.I.P.LPT++..phaTll.+SPHhp..K.....cSREQ.FEhRTHKRLIDI.l.......................pP.T...s+TV....DuL......M...+L-L.....suGV-lEIp.......................................	0	550	1016	1368
+4225	PF00411	Ribosomal_S11	S11;	Ribosomal protein S11	Finn RD	anon	Prosite	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.13	0.72	-3.88	13	6124	2012-10-02 16:33:16	2003-04-07 12:59:11	14	12	5534	199	1594	3230	2256	109.70	55	79.77	CHANGED	GlsHIpuSF....NNTIlTlTDlpGpslsWuSAGusGFKuoR.KuTPaAAptAApsAActsh-pGhpplEVpl+G........PGsG+-uAlRAlp+uGlhIspIcDVTPhPHN.GCRPPK+RR	.....................................................GlAHIpuoF....NNTIVT.I.T...Dh.p.......G........N.........s........l.u..W.....u.....SA...G.u.h.G.F...K.GSR.....K.STP.FA.AQ..hA.A...E...s.Auc..t..A.........h....E.......h.......G....l....+..s...l-...V...h..V.K.G..............................PGsGRE....o.A..l....RA.L.....p....u.....u...G.....l....c........l....o....tIpDV.TPlPH...N.GCRPPK+RR......................................	0	517	960	1328
+4226	PF00164	Ribosom_S12_S23	S12; Ribosomal_S12;	Ribosomal protein S12/S23	Sonnhammer ELL	anon	Prosite	Family	This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.	19.90	19.90	20.00	20.00	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.68	0.71	-4.69	18	6678	2012-10-03 20:18:03	2003-04-07 12:59:11	20	19	5947	204	1582	3422	2092	119.60	62	94.59	CHANGED	sThppLlR+c...........RcchtpcsKssALcGsPp++GlChclhslpPKKPNSAlRKlsRV+Lp..NGhcVTAaIPG-G..HsLpEHs.VLlcGGp......VtDLPGVRY+ll+GhhDsuGVp..tRtpuhSKYGsc+P+	.....................................TlpQ.Ll.R.+.s..............R.p...p.h.h.p+.s..+....sP.A.............L..............p...............u.............s.PQ+.RGV...CTRVh..............ThTPKKPNSALRKVARV..RL......o........NG......hEV.TAYIPG.G...HNLQEHSVVLlRGGR.......VKDL..PGVRYH..IVRG.sLDsuGVp........sRpQuRS...KYGsK+PK......................................	1	531	988	1316
+4227	PF00416	Ribosomal_S13	S13;	Ribosomal protein S13/S18	Finn RD	anon	Prosite	Family	This family includes ribosomal protein S13 from prokaryotes and S18 from eukaryotes.	24.60	24.60	24.70	24.70	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.39	0.72	-3.59	15	5791	2012-10-02 21:21:44	2003-04-07 12:59:11	17	7	5215	199	1480	3234	2174	105.00	49	84.93	CHANGED	RlhssslsusK+..lhhALTtIaGIG++pAptlhpcsslDtspRsu-Lo--plcpltphlsp.......................ahlpu-LcpclppDIcRLhcIcsYRGlRHhtGLsVRGQRTKTNuRT	.......................................RIAGVslPpc...K+..l.IuL.T.a.IaGIGpspup....pIltps.G.............ls.....s....h+lp.-Lo-...-plsplRc..ls.p.........................................................................ahVEGDLRREls.hsIKRLh-lG..s....YRGlRHR+G.LPVRGQ+TKTNART..........................................................................	0	503	954	1256
+4228	PF00253	Ribosomal_S14	S14;	Ribosomal protein S14p/S29e	Finn RD	anon	Prosite	Family	This family includes both ribosomal S14 from prokaryotes and S29 from eukaryotes.	19.70	19.70	19.80	20.50	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.84	0.72	-4.58	178	6805	2009-01-15 18:05:59	2003-04-07 12:59:11	16	10	5516	200	1562	3442	1882	54.30	45	63.36	CHANGED	hp..lpph.cspshsRhpsRChlsGRs+..uhhR+F.sl..sRhsFR-hAtpG.lPGlpKuS	................t..lpphP+s.usssRhpsRC............phsGRP+..uhh..RKF.GL..sRlphREhAhcGplPGlpKuS....................	0	508	968	1302
+4229	PF00312	Ribosomal_S15	S15; 	Ribosomal protein S15	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.90	20.90	21.10	21.90	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.55	0.72	-4.22	9	5932	2009-01-15 18:05:59	2003-04-07 12:59:11	17	14	5410	212	1580	3366	2136	82.00	44	77.02	CHANGED	htpthhlpphtcpppspGSsEhQlhhLTp+l.+LppHhccH+KDapSpRGLhphluKR++LLsYL+pcs.....hh+YcphIppLGlR	...................................c..Ksplltca..t..p..p..c..s..DT.GSsEVQlAlLTt+IspLs.cHhc..p.H....K..K.D+cS+RGLl+hVu+RR+LLsYL++pD......htRYcp...LIpcLGLR....................	0	536	990	1322
+4230	PF00886	Ribosomal_S16		Ribosomal protein S16	Bateman A	anon	Pfam-B_1025 (release 3.0)	Family	\N	21.20	21.20	21.40	21.60	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.89	0.72	-4.25	158	5911	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	5742	192	1200	2936	2304	56.10	47	58.89	CHANGED	RhGpK+pPaY+IVVsDuRssRD.G+aIEplGhYsPh....tp........................................plplch-+hphWlspGAQPo	..........RhGtK+p..P...FY+lVVsD.uR...s.....R..D.GR..hIEplGhY.....N..Plts..............................................plplch-+.lhaWLspGAQPo..............................	0	415	780	1019
+4231	PF00366	Ribosomal_S17	S17; 	Ribosomal protein S17	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.33	0.72	-3.93	15	5324	2012-10-03 20:18:03	2003-04-07 12:59:11	15	10	4890	201	1529	2971	1891	68.80	50	69.69	CHANGED	GhVVSsKMcKTllVcl-phthHPKYs+hlKRpKKh.AHsssshppl..GDlVcItEsRPLSKTKRFpVlcV	.............................GpVV.S.D.K..M-KTIsVtlE.p..........hh.p.HPlY.u.........K.......hl++opKh....+AHD.Es..N.p.s..p.l....GDhVcI..h.E.s.RPLSKTKpapLVc........................	0	521	966	1279
+4232	PF00833	Ribosomal_S17e	Ribosomal_S17; 	Ribosomal S17	Bateman A	anon	Pfam-B_1566 (release 2.1)	Family	\N	22.80	22.80	23.30	24.70	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.63	0.71	-4.36	32	683	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	508	9	396	637	67	107.30	53	84.61	CHANGED	MGRVRTKTVKRAuRhllEKYYs+LT.hDFppNK+ls-E..VAlIsSK+LRNKIA...GasTHLMKRIp+GPVR....GISlKLQEEERERR.saVPEhStlDhs......hlpVDt-Tp-ML+p.hsh..slsshhl.st	.........MGRVRTKTVK+uu+hlIE.+YYs+LT.hDFcTNK+ls-E...lAlI.s.SK+LRNKIA...G.YlTHLM.KRI....Q+G.PV.R....GIShKLQ.EE.ERER+.paVP-hSAl.-.p........lcVD.-Tt-hLc..Lsh..pls......s................................................................	1	138	226	324
+4233	PF01084	Ribosomal_S18	S18;	Ribosomal protein S18	Finn RD, Bateman A	anon	Pfam-B_712 (release 3.0)	Family	\N	21.00	21.00	21.20	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.46	0.72	-4.10	121	5681	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	5182	193	1326	2673	1849	53.20	50	56.97	CHANGED	tpphp.hlD....Y.KcschLp+Flo-.pGKIlPRRlT..GssuKpQRplspAIK+ARhlALL	......................s..thppID.........Y.KDs.shL+c.FIoE.pGK..IlPRRlT..GssuKtQRplspAIKRARhluLL............	0	451	833	1106
+4234	PF00203	Ribosomal_S19	S19;	Ribosomal protein S19	Finn RD	anon	Prosite	Domain	\N	21.00	21.00	21.00	21.00	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.69	0.72	-4.36	22	7420	2009-01-15 18:05:59	2003-04-07 12:59:11	16	5	6888	210	1487	3278	2069	78.30	55	82.39	CHANGED	Rol+KsPFssh+Lh+Khcp.s.ttcK.phl+TWSRsSsIlPpMlGpslulYNGKpal.VhIoscMlGHKLGEFu.TRphttH	..........................................................RSLKKuP.F.V.s.t.H.L.h....+K...............l...-.t.h....s........t...p...........t.c.K...cs......I+TW...S...RpST.IhP.shlGhTIA.VHNG..+cHl.PValT.-.c.MV.G.HKLGEFAPTRTapGH.............	1	498	945	1255
+4235	PF01090	Ribosomal_S19e	S19e; 	Ribosomal protein S19e	Finn RD, Bateman A	anon	Prosite	Family	\N	24.20	24.20	24.50	25.30	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.46	0.71	-4.75	62	756	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	526	9	441	663	97	128.00	43	85.22	CHANGED	sTVcDVsscchlptlAphLKcs.s+lcsP-WsshVKTGsaKEhsPps.sD.WaYhRsASlhR+lYlcu.PlGVtpl+phYGG++c..+G..s+Ps+as+uSGulhRpsLQpLEphGlVcKs......psGRplTspGpp.LD+lAtplhpcht	..............................oV+DVstpchlpshAtaLK+p...GKlcl..........PpWsDhVKTu.ttKEhsP.-...D.WaYhRs...ASlhR+lYlRs.........slGVG..php+lYGGppp....pG..spPsHascu.SGulhR+sL.QtLEphtllEps.........pu....GR.plTtpGp+DLD+IAsplhtt.p......................	0	182	268	368
+4236	PF00318	Ribosomal_S2	S2;	Ribosomal protein S2	Finn RD	anon	Prosite	Family	\N	23.80	23.80	24.00	23.90	22.30	23.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.26	0.70	-5.11	177	7370	2009-01-15 18:05:59	2003-04-07 12:59:11	15	20	5811	224	2025	5251	3040	185.10	40	79.94	CHANGED	lLcAGlHh.GH.p......sphWNP+Mp...Y.Iasp.R..s...GlHIIDLpc.ThthlppAhchlpphst.ps....................................................................sc....lLFVGTKp...pu..pchltctApcs......sth.al.s.....pRW.lGGhLTNapolppplpphc......h................t.hsK+p.h.htcpht+Ltp.hsGlpphtpl..Pc....l...lhllDs....pp-p.AlpEApcLsIPll..ullDTNssPsh...lDasIPuNDDuh+ulpLhhphluculhcup	.....................................................................hLcAGVHF.GH.p......T..+pWN.PKMt...a..Iasp....R...s.........................u.l.a.IIsLp+.Tht.hhp.pAhphl....pphst..ps....................................................................splLFVG.TK+........pA..............p-slt....c...tA.tcs.............s.th...aV..N.........pR.W.LGGhLTNapTl..ppplp.+hc.c....lct.tpsG.............................hphhsKKEhh...h.p+pht+.L.pp.....LG.GIcp.........Mttl..........Pc................h.lhllDs.....pc.E....p..hAlpEA....ppLsI....Pll..ul.l.DT.N.sc.P-.................lDhsIPu..ND.DAh+ulpLhhthhApAlh-u......................................................	0	683	1211	1641
+4237	PF01649	Ribosomal_S20p		Ribosomal protein S20	Bateman A	anon	Pfam-B_1685 (release 4.1)	Family	Bacterial ribosomal protein S20 interacts with 16S rRNA [1].	20.60	20.60	21.40	21.40	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.93	0.72	-3.60	14	4402	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	4355	191	972	2284	1917	80.90	41	93.95	CHANGED	ANhKSApKRh+psp+pRl+NpuhKStl+ThlK+shpslpss-ps.......tAppths.stphlD+supKGllHKNpAAR+KS+LAttlpp	...........ANhKSAhK.Rscpsp+ppt+Ntuh+SthRThlK+s.c....tAlts.s.D.p.p...................sAp..pthptApphlD+sA..s.KGlIHKNpAAR+KSRLutplp.t...................	1	342	654	833
+4238	PF01165	Ribosomal_S21	S21; 	Ribosomal protein S21	Finn RD, Bateman A	anon	Prosite	Family	\N	21.00	21.00	21.70	21.30	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.66	0.72	-4.52	140	4324	2009-01-15 18:05:59	2003-04-07 12:59:11	15	5	3974	61	1053	1753	1966	57.00	45	77.38	CHANGED	s.pVplpcs-.sl-pALRRFK+php+sGlhp-h+cRc...aaEKPotcR++Kpttut++p.t+	............s..lhV+-NE.shDsALRRF...KRs.spKsG.........llpEhR+.R.E...aYEKPoscRK.++ptuAhKRch+.............	0	333	644	864
+4239	PF01249	Ribosomal_S21e		Ribosomal protein S21e 	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.40	25.10	18.30	19.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.94	0.72	-4.04	36	472	2009-01-15 18:05:59	2003-04-07 12:59:11	13	8	349	6	258	420	6	79.10	54	76.04	CHANGED	MpNDsGchVDLYlPRKCSATNRlIsAKDHASVQINlucVDts.G+.hsGphpTaA...lsGhlRphGESDcslsRLspccGllsps	..................MpN-tGch.VDL..YlPRK......C.S.AoNRIIpAKDHASVQIslucV.Dcs..GR.hs.GphpTYA...lsGhlR......th....GESDD.ulsRLApc-Gllt..s......................	0	88	142	211
+4240	PF01282	Ribosomal_S24e		Ribosomal protein S24e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.30	25.00	24.30	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.61	0.72	-4.19	70	778	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	520	12	448	664	66	83.90	46	63.63	CHANGED	hhl-lhHsup.uosS+p-l+-KLAphhps.ss-tlhlash+TpFGsG+osGauhIYDsh-thKchEPcatLhRs.slhpc.ct..tucc	..............................hVlDVLHPG+.AoVsK........sElREKLAchY.Ks.ss-sl.hVFGFRTpFGGGKoT..GFuhIYDol-hAKKhEPKa..RLsRp..GLhcKhc..uR.p.......................................	0	129	224	315
+4241	PF03297	Ribosomal_S25		S25 ribosomal protein	Mifsud W	anon	Pfam-B_4038 (release 6.5)	Family	\N	28.80	28.80	28.80	29.10	28.70	28.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.42	0.72	-4.00	24	591	2012-10-04 14:01:12	2003-04-07 12:59:11	10	9	405	8	328	514	4	102.30	49	83.60	CHANGED	MPPKc........p..pttKtttusuGGKs.+KKKWSKGKs+DKLsNhVlFD.KuTYDKLhKEVPsYKlITsSVlS-RLKIsGSLARpALc-Lpp+GlIK.V.s+HpuQhIYTRus	.....................................t......t.t.pt..s.s...t.uGGKt..cKK.KWSKGK..V.+DK...lNNhV.L.F.D..csTYDKLhKEVPs..Y.KLIT...PuVlS-RLKIpGSLARtALp-Ltp+GlIKhV.spHpsQhIYTRs.................	0	112	176	252
+4242	PF01283	Ribosomal_S26e		Ribosomal protein S26e	Finn RD, Bateman A	anon	Prosite	Family	\N	20.70	20.70	20.70	21.00	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.46	0.71	-3.85	37	581	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	425	4	325	528	16	107.20	56	86.00	CHANGED	MspKRRNsGRsK..+uRGHVp.lRCoNCuRsVPKDKAIKRFslRNlVEsAuhRDlp-Au.lY...psYslPKLYhKhpYCVSCAIHu+lVRlRSc-.....sR+.Rsss.+h....t.ttp.sst.s	...............MspKR+NsGRsK..+G.RGHVpslRCoNCuRClPK..DKAIK+FslRNIVEu..AA........lRDlsEAS.Va...............stYsLPKLYsKLpYCVS.CAIHu+lVRsRS+E.....sR+sRsPP.Rht.t.........ss..............................	0	118	180	260
+4243	PF01599	Ribosomal_S27		Ribosomal protein S27a	Bashton M, Bateman A	anon	Pfam-B_638 (release 4.1)	Domain	This family of ribosomal proteins consists mainly of the 40S ribosomal protein S27a which is synthesised as a C-terminal extension of ubiquitin (CEP). The S27a domain compromises the C-terminal half of the protein. The synthesis of ribosomal proteins as extensions of ubiquitin promotes their incorporation into nascent ribosomes by a transient metabolic stabilisation and is required for efficient ribosome biogenesis [3].  The ribosomal extension protein S27a contains a basic region that is proposed to form a zinc finger; its fusion gene is proposed as a mechanism to maintain a fixed ratio between ubiquitin necessary for degrading proteins and ribosomes a source of proteins [2].	21.30	21.30	22.50	22.50	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.58	0.72	-4.14	12	740	2012-10-03 10:42:43	2003-04-07 12:59:11	14	11	555	5	375	629	45	45.60	58	31.50	CHANGED	AVLcYYKVDssGKlpRLR+ECPt.pCGuGVFMApHtDRpYCGKCthT	..................AVL+aYKV...D.c.s..G..K.l.....pR.LR+EC...Ps...cCGA.GV.FMAsH...h...D...RpYCGKCshT........	0	122	208	302
+4244	PF01667	Ribosomal_S27e		Ribosomal protein S27	Bateman A	anon	Pfam-B_1929 (release 4.1)	Family	\N	24.50	24.50	24.50	25.30	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-8.76	0.72	-4.42	7	748	2012-10-03 10:42:43	2003-04-07 12:59:11	12	5	546	9	399	669	46	54.30	62	63.75	CHANGED	PpShFlcVKCPsChs.psVFuHupThVhChtCupsLspPTGGKu+lptth..hhc	..............................PsSaFMDVKCPGCapITTV.FSHAQTVVlCsuCuTVLCQPTG.GKA+L.TEGCSFR+K..........	0	125	218	314
+4245	PF01200	Ribosomal_S28e		Ribosomal protein S28e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.70	25.70	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.15	0.72	-4.23	38	607	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	501	10	344	470	76	67.10	58	88.74	CHANGED	M-pt......ptsh.....AcV...lcllGRTGscGplTQV+V+lLcs.sp....sRhlhRNVKGPVRhG..DI.LhL...hETEREA.R+Lc	.........................p.sphAcV...h+V..LGRTGSpGpsTQVRVcFl--..ss.....RpIlRNVKGPVREG..DI.LsL...LEoEREA.RRLR......	0	109	191	285
+4246	PF04758	Ribosomal_S30		Ribosomal protein S30	Wood V, Bateman A	anon	Wood V	Family	\N	20.00	20.00	21.00	20.70	18.70	17.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.83	0.72	-4.22	23	515	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	387	7	297	462	15	57.30	61	58.05	CHANGED	KVHGSLARAGKV+sQTPKVsKpEK+.Kp.sGRA+KRhpYNRR....Flsll.t.G...+K+GsNups	.....KVHGSLARAGKV+.uQTP..KV....-KQ....E..KK....Kp.pGRA++RhpYsRR....FVNVs...s.hG....pK+t.Nss.......................................	0	113	168	244
+4247	PF00189	Ribosomal_S3_C	S3_C;	Ribosomal protein S3, C-terminal domain	Sonnhammer ELL	anon	Prosite	Domain	This family contains a central domain Pfam:PF00013, hence the amino and carboxyl terminal domains are stored separately. This is a minimal carboxyl-terminal domain.\	  Some are much longer.	21.30	21.30	22.30	21.80	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.64	0.72	-3.77	124	7624	2009-01-15 18:05:59	2003-04-07 12:59:11	15	11	7097	199	1388	4926	2193	82.90	50	31.68	CHANGED	pl..........uppLEc+........h.sFR...+sh+psl......pph......psu.s.cGl+lplSGRL...sG....s-hARsEh..hpc........Gpl..sLpolcspIDYuhspAtTphGhlGlKVWI	...................................................IAtQL.cpR..l.uFR...RA..hKpAl.........pps................hpusA..+GIKl.plSGRL....sG.......AEIA.RoEh..a+E.................G+l.........PLpTlRAcIDYuhtEAcTp........YGhlGVKVWI.....................	0	478	888	1168
+4249	PF01015	Ribosomal_S3Ae		Ribosomal S3Ae family	Bateman A	anon	Pfam-B_1334 (release 3.0)	Family	\N	25.00	25.00	27.20	27.10	22.10	18.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.05	0.71	-4.98	69	888	2009-09-11 07:57:53	2003-04-07 12:59:11	13	8	583	4	470	815	113	191.30	50	82.23	CHANGED	ut+Kst.t+hhDsap.pKcWYslhAPsh.F....sppplGcThssc.......s-tlhGRlhEsoLuD.LssD.p..psapKl+hplpcV.pGc..sshTpFhGh-hTcDhlRSLVR+hpohI-uhl-V+TpDGYh.lRlhsluaTp++............ApsSQh+sIRcphh-llpccusptshcphVpcll...............sslup-I.c.ps+pIYPL+cVtIRKlKlLcpPc	..........................................................tuKKGh.KKKssDPFs.+K-WY-l..KAPsh.F....s.hRs...lGKTLVs+opG.....................h+.As-uLKGR.....VhEVSLAD.Lps...D.-....puaRKh+Lhs-.-V..QG+..Ns.LTNFaGh-hTpDKlpShV.+KWp.T.hIEApV-VKT..oD.uYh.L.RlFsluF.....T+++.sQh...++TsYAppoQlR.tIR+KMhEI.hpccs................psssL..cclV..pK.l.I..............P-s...Iu+-IEK.uspsIYPLp.sValR.KVKlLKpP+..........................................	0	157	256	356
+4250	PF00163	Ribosomal_S4	S4;	Ribosomal protein S4/S9 N-terminal domain	Bateman A, Sonnhammer ELL	anon	Prosite	Family	This family includes small ribosomal subunit S9 from prokaryotes and S16 from metazoans.  This domain is predicted to bind to ribosomal RNA [1].  This domain is composed of four helices in the known structure.  However the domain is discontinuous in sequence and the alignment for this family contains only the first three helices.	21.70	21.70	21.70	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.14	0.72	-3.61	18	11914	2009-01-15 18:05:59	2003-04-07 12:59:11	14	7	10020	203	1485	8634	2034	83.20	44	43.67	CHANGED	uR.YpGsphKhsRR.sphstLssc....ppptsp......pstpcshps+h........+hSpYtlpLcEKQKlRhhYG.lhERQLhpYsclu...pKh+GspG.slhplLE	...................................................................................h+h.RRhG..h....h..Lss.+.............t..t.h.c.s...............ss.tppu..tspp..............K.lSpYtl.p...L..c.E.KQK.LR.a.pY.......G..loERQhhpYh+hA...........p+tK.G..s...T..GpsLLQLLE.........................................	0	530	969	1271
+4251	PF00900	Ribosomal_S4e		Ribosomal family S4e	Bateman A, Finn RD	anon	Pfam-B_1205 (release 3.0)	Family	\N	25.00	25.00	25.00	25.50	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.35	0.72	-4.31	81	821	2009-01-15 18:05:59	2003-04-07 12:59:11	15	13	555	7	448	754	91	75.80	52	30.43	CHANGED	cosEpaRllhDs+GRhslpcIss-EAphKLs+lpsKshspsGhsplshHDGRslhhsp.........sph+ssDolhlsl...ssp......cIh	.....KTsEpFRLlYDsKGRFslH+Ios..EEAc...YKLCKV+.+lph.......Gp+GlPa.LsTHDGRTIRYPD.........PhIKsNDTlplDL.tosKIh.....................	0	144	246	342
+4252	PF00333	Ribosomal_S5	S5; 	Ribosomal protein S5, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	27.00	27.00	27.00	27.20	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.04	0.72	-4.23	13	5805	2012-10-02 17:51:51	2003-04-07 12:59:11	15	11	5179	202	1620	3309	2088	66.50	52	34.20	CHANGED	cLpE+VlslpRVsKhs+uGR+hpFpAlVVVGDcNGpVGhGhGKA+E.VssAIpKAltpAK+sllsVsh	.....................pLpE+llsINRV.sKs.V.KG.GR+hpFs..ALVVVG..D.t.s.G+.VGhG.hG.KA..+.E..VPsAIpK.Ah-pA++..shlpVs.h....................................	0	552	995	1332
+4253	PF03719	Ribosomal_S5_C		Ribosomal protein S5, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.40	20.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.26	0.72	-4.70	114	5623	2012-10-03 01:04:38	2003-04-07 12:59:11	10	12	4962	202	1648	3246	2178	73.10	45	37.14	CHANGED	VhG+aGuu+Vhl+PAstGTGlIAGG.ssRuVlEhAGlcD....lhsKohG.SpNshNhl+AThcuLpphposcplAphR.G	................lpGcaGuucVhlpPAscGT.....GlIA.GG.ssRAV.LEhA.GlcD.....lluKo.h.....G...Ss..NP..hN.lV+AT.lcu.L.p.p.hpss.cplAthRG....................	0	557	1007	1357
+4254	PF01250	Ribosomal_S6		Ribosomal protein S6	Finn RD, Bateman A	anon	Prosite	Domain	\N	21.00	21.00	21.10	21.00	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.76	0.72	-4.14	180	4748	2009-09-12 05:02:19	2003-04-07 12:59:11	12	8	4630	210	1190	2634	2089	91.70	35	77.12	CHANGED	+pYEhhaIlcPcls-c.phpshl-chpsllppp.uGplh.ch-p...W.Gc.R+LA.Y.IpKh..........pcGaYhlh.phpu..s.spslpEl-Rth+ls-sllRahsl+h	......................p+YElhal...l...+...P.s..hsEp...phs......uhlE+a.psllsss.GGplp.ch-c...W.G+....RpLA....Y...Ip....K.h.....................................+cGaY.....hll.slcu..s...spsls.El-+.....hh+.....l.....s.-sllRphll+.h...................................	0	409	769	1011
+4255	PF01092	Ribosomal_S6e	S6e; 	Ribosomal protein S6e	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.20	25.20	24.10	24.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.45	0.71	-4.50	7	798	2009-01-15 18:05:59	2003-04-07 12:59:11	14	6	566	5	447	741	92	116.50	52	53.22	CHANGED	MKLNlSaPtsGsQKhlElDD-+plRhFh-KRhGpEV-u-hlG.EacGYsl+IsGGNDKQGFPM+QGVLsssRVRLLhucGpsCYRPRRsGERKRKSVRGsIVsssluVLsLsIl++GEp-IPGLTss	.................................hKlNlu.PssGsQKhlEl.-D-p.+lR..Fh.-KRhupEVsu........-........s..L........G........-........E.a.........K............G.........Yl.h+IoGGsDKQGFPMKQ.GVLsssRVRLLLs+G............ps.CY..R...P...R..R...............sGERK.R.KSVRGCIV........sssLuVLsLlI.V.K.pG...Ep.....-lsGLTD.........................................	0	141	238	341
+4256	PF00177	Ribosomal_S7	S7; 	Ribosomal protein S7p/S5e	Sonnhammer ELL	anon	Prosite	Domain	This family contains ribosomal protein S7 from prokaryotes and S5 from eukaryotes.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.77	0.71	-4.62	166	7992	2009-01-15 18:05:59	2003-04-07 12:59:11	16	14	7200	206	1618	4678	2374	146.70	44	86.24	CHANGED	MsR...+.tpst+R...l.s....Dshasst.........lVs+hlNplMh....................cGKKulApcIlYpAh-hl............pp....+.spp...sP.................lp.....lhppAlcNlpPtlEV+.......uR......RlGGuoYQV.PlEV.ps.pRphsLAlRWllpuuR....p.......Rs.t+..sMsp+LAsEllDAu.ps..pGsAlKK+E-sH+M...AEA.N+	.....................................................sR+..sphs++...h...s....Dshapst.........lVs+.llNplMh....................cG....KKuhA.pI...VYpAh-hI......................................cp.....+...Tuc.........sP..........................................................Lp.....VhppAlpNltPt.l-V+........uR......R...lG.Gu.sa.Q.V.PV.EV..pP.tRRssLAlRWLlsuAR............h...........Rs....tK.....oMs-+LAsELlDAA..ps...pG..........sA.lK.K+E-sH+M...AEAN+..........................................................	2	573	1027	1367
+4257	PF01251	Ribosomal_S7e		Ribosomal protein S7e	Finn RD, Bateman A	anon	Prosite	Family	\N	26.60	26.60	26.60	26.90	26.10	26.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.14	0.71	-4.82	27	599	2009-01-15 18:05:59	2003-04-07 12:59:11	13	7	415	4	298	532	6	174.90	53	92.14	CHANGED	sKIhKpsst....PoEhEpsVAQALhDLEsss...-LKupL+sLplsuA+E.l-luu.sKKAlllaVPhP.Lpua.+KIQt+LsRELEKKFus+cVlhlApRRILs+PpRp..tt...ppQKRPRSRTLTAVH-uILEDLVaPuEIVGKRlRh+lDGo+lhKVaLDp+-pss..lEaKl-oFsuVY+KLTGK-VsFEFP.stt	............................................Kl.Ksp..stp...PsEhEps.luQ..........ALh....-LE.ss...DLKu.pLR.c.LtIsuA+E...l-Vus.....s+..............KAll.IaVPhP.L.+uF.pKI..QsRLlRELEKKFS.G+.HVlhlAp.RRI.LPK.PpRp..s+....ppQKRP.R.S.RTLTAVHDAILEDLVaPsEI..V..GKRlRh.....+lDGS+llK.....Va.L.Dp.pppss..lEa.Kl-TFuuVY+KLTG+-VsFEFPt...................	0	102	164	239
+4258	PF00410	Ribosomal_S8	S8; 	Ribosomal protein S8	Finn RD	anon	Prosite	Domain	\N	24.00	24.00	24.50	24.50	21.10	23.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.51	0.71	-4.30	119	6129	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	5619	211	1551	3553	2221	126.70	42	95.88	CHANGED	DsIuDhLTRIRNAphsp+ppVpl.Ps........................SKlptslhplLpcEGYIpsaph.........hppppp...t...............................lplp.LKY.........pttps..lIpplpRlS+PGhRlYsstpclP+.......lh..sGhGl...........sIlSTS+G.lMoc+cARcppl.GGElLChVa	....................................................DPIADhLTR..IRNA.pts.p....+psVpl..Pu........................SKlK..tsIs.plLpc.EG...........aIcsach...........................hc..-..s.p..t......t.......................................................................lplp.LK.Y.............ptct..........lI.p...s...l..cRlS+PGLR..lY.sptc-.lP+.........Vh......sG..L...GI............................uIl.....ST..Sc....G......l...hTD+cA.Rp...............psl..G.GEllsYVa..........................................	0	516	966	1289
+4259	PF00380	Ribosomal_S9	S9;	Ribosomal protein S9/S16	Finn RD	anon	Prosite	Family	This family includes small ribosomal subunit S9 from prokaryotes and S16 from eukaryotes.	21.80	21.80	21.90	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.56	0.71	-3.86	183	5483	2009-01-15 18:05:59	2003-04-07 12:59:11	14	9	4963	199	1599	3183	2185	121.50	50	81.31	CHANGED	GRRKoulARVhl.ps.G.....................s....G.p.lplN.s+............sh...p-Ya..spphhphplhpPLt.lssp...........................................................hsp...............................aDlhlp.................VpGGGhoGQAsAlRhuIARALlp.....................................hs....sp............h+stLKpt......GhLTRDsRhhERKKa..Gh++AR+p.QaSKR	...............................................GRRKsulARVhl...hP...G.................................................s.....G...cI..slN.s.+.....................s.lcpYa..s....pc........sh.chhl.pQPL.t.l.s.pp...........................................................h..s..p................................aDlhls.................V.p.G..GGhoGQAG.....A.IRHGIuRAL.hp.............................................hD...ss..............hR.ssLKcA..............................................GhLTR..DuRhsERKKh..GL..+KAR+tsQFSKR......................	0	557	1015	1351
+4260	PF00834	Ribul_P_3_epim		Ribulose-phosphate 3 epimerase family	Bateman A	anon	Pfam-B_1291 (release 2.1)	Domain	This enzyme catalyses the conversion of D-ribulose 5-phosphate into D-xylulose 5-phosphate.	20.60	20.60	20.60	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.32	0.71	-5.21	13	6022	2012-10-03 05:58:16	2003-04-07 12:59:11	14	17	4642	50	1359	4019	3152	198.40	43	88.92	CHANGED	hlAPSILSADFu+LucElpslppuGuDhlHlDVMDuHFVPNlTlGPhVlculRsh...sphPlDVHLMlcssDphlssFAcAGAs.hIoFHsE..AocHlcRolphI+ctGsKAGlVLNPuTPLssl-alL-clDlVLlMSVNPGFGGQuFIPssLsKlcpl...R+hhsp......hshhlEVDGGlsscshtplscAGAshlVAGSAlFuus	.....................................................................................................................................IAPSILSAD..F...ucLu.c-l.ppl...p......t...u.....G...A.DhlHlDVM...D........G..........HFVPN...l.T..h..Gs..llcu..l.Rph...................sphP.....l.DVH.L.Ml....p......s..............P..-.......c.......a.lss.F...Ac.A......G..A.s....hI......oh.H.sE..................A.s......p....H......l...c.......R......s.l...p...h...I.+........p......t.....G....h.K...................A.........Gl.s........l.N.P.u.T..P.l.p.h...l.c....l..l......c........p......l.......D.h..lLl...M.o.......V.N....P..G.F....G...G....Q...p...F...Isp.s.l...cK.l.cpl......+..phhc.pps..................hs.hpIEVDGGl.s..s.p.s.h.tphs.p..AG.A-.hhVA.G.S.u.lFpt.s.....................................	0	465	866	1148
+4261	PF02009	Rifin_STEVOR		Rifin/stevor family	Bateman A, Lawson D	anon	Lawson D	Family	Several multicopy gene families have been described in Plasmodium falciparum, including the stevor family of subtelomeric open reading frames and the rif interspersed repetitive elements. Both families contain three predicted transmembrane segments. It has been proposed that stevor and rif are members of a larger superfamily that code for variant surface antigens [1].	34.70	34.70	35.40	54.50	33.20	34.60	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.28	0.70	-4.77	16	412	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	2	0	71	414	0	288.50	30	96.01	CHANGED	aNp..Np.hITs..ppsshoo......RhLsEC-las.spYDNDPEMKcVh-pFscpToQRF+EY-ERhhspRpKCK-psDK-IQcIIlKDKhE.........................KSlA-KVEKsCL+CGssLG.GlhsusGlhG...slulsph.sp....uAthsAhp.h.csu.................htsslcph.......cuhsphhshhsh...............thhpulhssssYps.hsllsslhs.tstshCshspsstsshhshsspsttshhstp....................VpshspsAsssAptsspthstsltptssuhhss........IhuSllAIllIlLlMlIIYLILRYRRKKKMpKKhpYhKLLpc	.....................p........h...ps......R.LsEC-las.s.Y-sDsEMKpVh-pFs.cpT.pp.RF....cEYcE.+h.cpRpppKEps-KpIQ..KIIhKDKhE...........................KSls-KsEKt.CLcCuhshG.ulssphGlhu...........shshsth.ps........sshss....u..hp.u...ttu.....................htssltts..........c.shsphhthhph....................tshpslhsss.....sasshhslh......shlts...th.........t.s.h...s..........s..h.........s........s....s.....s.......t..............h...shsh...thhph..hst.......................................stphhps..usssutt....ss..s.th.s....s....shtstthu...hhps.......tsIhuSslslllIll.lhlIIYLILR.YRR.+K.phKhp..KhL.......................................	0	71	71	71
+4262	PF02197	RIIa		Regulatory subunit of type II PKA R-subunit	SMART	anon	Alignment kindly provided by SMART	Domain	\N	20.30	20.30	20.40	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.42	0.72	-4.52	13	656	2012-10-01 20:11:07	2003-04-07 12:59:11	12	27	223	33	372	614	5	37.00	33	10.58	CHANGED	pulpsLLcshsspVh+ppPuDllpFstsYF.p+LpcpRt	...........slpplLcshthpllpppPs....clh...pFsspYF..p+Lpptp..........	0	132	172	259
+4263	PF01782	RimM		RimM N-terminal domain	Bateman A	anon	PSI-BLAST P51419	Domain	The RimM protein is essential for efficient processing of 16S rRNA [1]. The RimM protein was shown to have affinity for free ribosomal 30S subunits but not for 30S subunits in the 70S ribosomes [1].  This N-terminal domain is found associated with a PRC-barrel domain [2]. 	23.50	23.50	23.50	23.90	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.74	0.72	-4.06	170	4228	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	4195	7	921	2739	1298	83.60	27	46.27	CHANGED	hlGpIsssaGl+Gpl+lhsh.T-....s-thhshtshhht..................pttt............hplpph+.hp..pp.thllphcGlss+spA.ctLpGtpl..hlscsp	..............lG+lsssaGl+Gcl.+Vhs.h.TD......s-..p.hhc.h..ss..hhht.......................................pssp.........h.t..........lplps..h+..hp..........ps.hhll+hcG.....ls.....stssA.ctLpstplhlspp................................	0	302	605	781
+4264	PF00848	Ring_hydroxyl_A		Ring hydroxylating alpha subunit (catalytic domain)	Bateman A	anon	Pfam-B_407 (release 3.0)	Domain	This family is the catalytic domain of aromatic-ring- hydroxylating dioxygenase systems.  The active site contains a non-heme ferrous ion coordinated by three ligands.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.46	0.70	-4.68	128	4563	2012-10-02 19:24:03	2003-04-07 12:59:11	14	18	1613	110	962	3945	3034	206.60	16	58.44	CHANGED	hp.ph.phttphphc....................hpsNWKlhh...-NahE.sYH..hs.ssHsph.t...hppht............................................t.t.h.h..............h.hshttt.tttsth......th.pptphtsh....................hhhlFPNhhlt.hhsshhh...hhphhP...husspsphphphhhtss............tssch..............tpphtphhpt............ltpEDhthscphQpG....lpo.....................sh..tsu..h.........sttEt.sl..pp....Fpphltchl...st	...................................................................................ht.hhp.......................htsNWKhhs..Es.h.h-...sYH...ss.hsH....shs.p.s.h..tths....................................................................t...hth..s.tts.hh..............................h...t.sh.s.h.p.hhtt....hsttp.h.......................t.ht..tt.....h..thh....................................................................th.s.la....Psh.hh....................ss..thh.............hphh.hP.......hussc...sp..h...hhhh.hs.t.s.....................tstch.....................ppthhp.h..t........................ht.pDht.htt....pts.......hts.....................................................................................-.............h......t..................................................................................................................	1	181	516	777
+4265	PF00161	RIP		Ribosome inactivating protein	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.10	20.10	20.70	20.70	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.47	0.70	-5.14	73	945	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	239	176	103	936	0	197.20	29	61.64	CHANGED	sFslssus...psYssFlpsLRsplsssstt.......hs..lPlL.......ssssp+alhlcLps....ssp.....lTLulchsNlYVlGY......psssphahFp............psspssLhsss.....tpppL.sasGsYssLpptush......Rpp.lsLGhptLssulssLhths...................................sspstAcsLllhIQMluEAARF+aIcppltssh........tpshpPs...sthlsLcssWuplSptlppu	...................................................................................Fsht.ss...tsYss.lsslRppl..tp.hpp........hpt..hsVhs.p.......tssstpahhl-lpsh..........ptp....p.lpLhlchsNLYlsGFh........sssssaapFs................................-hsphhhsss...........pshsl.shsu.s.YssLppsuu............Rps.hpluc.tsLssuh.s.Lhpassss.................................ppstu+......ullt.hlphsuEA....hRFp..Ipcphcpsh...............tpsp..shshs...st...t.ls..hp.s.WuclSpsl................................................	2	2	17	64
+4266	PF04957	RMF		Ribosome modulation factor	Bateman A	anon	COG3130	Family	This protein associates with 70s ribosomes and converts them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells.	27.90	27.90	28.20	28.70	27.10	27.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.69	0.72	-4.28	27	514	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	498	3	92	194	24	54.70	67	89.99	CHANGED	MKRQKRD+hcRAas+GYQAGlsGRS+EhCPap.sh-s.RspWLuGWREuhpD+hsGh	....MKRQKRDRLERAapRGYQAGIuGRSKEhCPYQ.sLsp.RStWLGGWR-AMtDRss..ht.......	0	17	34	64
+4267	PF04321	RmlD_sub_bind		RmlD substrate binding domain	Waterfield DI, Finn RD	anon	COG1091	Domain	L-rhamnose is a saccharide required for the virulence of some bacteria. Its precursor, dTDP-L-rhamnose, is synthesised by four different enzymes the final one of which is RmlD.\	\	\	   The RmlD substrate binding domain is responsible for binding a sugar nucleotide [1,2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.59	0.70	-5.52	37	4012	2012-10-10 17:06:42	2003-04-07 12:59:11	12	20	2929	21	1194	32857	21491	276.30	30	91.82	CHANGED	Mp.lLlTGusGQlGp-Ltcthtt.pshslluh.s+s...........phDlscspultphl.........pph+Pc..lVlNsAAaTAVDpAEs-..-tAhtlNutGsttlAcust.phGs.LlalSTDYVFDGs........tsts.YpEsD.ssPhslYGpoKLtGEpAVhs..sss.cthllRTuWVY.ut...tGp..NFVcTMl+LA..tpccplpVVsDQhGsPThstslAcslhtlhpphhp........hGlaHhsssGt....soWasFAptIhcpsstps........cVpPlsospaPpsApRPt.SsLssp+hptshsh.h.s.WcpuLtchlpphht	..........................................................................................................................................p.lLls.Gu.s.GQ....LG....p......p........L.t.......p...........h.......h......s.........t.......t............s...............p.......h.......l..uh...sts.....................................................ph.D......l...s...s...........p........s.......l......p......p.....h...l.......................................p..p.....h.....p.......P........c..........l......l........l......N....s...A.......A........a.......T.......s.......V.....D.......t........A.....E.........s....-....................c......h....u..............h.......t.......l...........N.....s.......p....u..s...........p........p........l............A..........p..........s.............s...............p...........p...............h...............u..........u...............h.......l..........l...........a....l...S...T..........D.....Y......V.........F.........-....G.p................................t.s..t..s.....a.....p......E......s.........D.........t.........s.........s.........P..........h........s........h..............Y.......G.....p.....o...K....h.......t.......G....E.....p.......t.....l......tp..................hs...........s.......c............h..........h.........I..........l......R........T..........u.....W.......l.....a...ut....................hG..p.......N......F.......l......p.......T.......M.........l........c.....L.u........pp.......+................c...........p..................l......p........V......l........s...........D.........Q........h........G......s........P........T..........h....s......t......s...L...A..c.h.....h.........h.....p.....l....l...p.....p.t...t.t..................................hG.l.YHh..s..s..s..u.t................s..oW....a....-...a.A....p....t....lhc.t.s.sh.t.........................p.l.p...s....l..s..o.....s......p......a.....s.....t..............A........t.....R....P....t........S.....h...L...stp+.....h.p.t.t....h..........s..h...............h........s..Wppultphht...th..................................................................................................................................................................................................................................................	0	375	753	996
+4268	PF03035	RNA_capsid		Calicivirus putative RNA polymerase/capsid protein	Griffiths-Jones SR	anon	Pfam-B_1282 (release 6.4)	Family	\N	19.50	19.50	21.00	20.70	19.00	18.00	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.72	0.70	-4.55	34	896	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	582	0	0	699	0	183.40	57	98.34	CHANGED	MAGAhlAGLAu...DhluuulGoLIsAGANAlNQ+h-a......................c.Npp...........LQpsSFpHDKEMLpuQlpATppLQtchlsl+pulLsAGGFSssDAARuulsAPhT+l.lDWN...GTRaaAPs......ShpTTsaSGpFsssss............p...................ssssohpopST.Soslossstss..................osssSRTosWVpsQN............p.LpPahpuALpTsaVTPPSSp.uSSs.........uoVSTVP+tlLDSWTss.....FNT+RQPLFAplR	........................................MAGAFhAuLAu....sllusulGSLlsAGAsAlNQ+h-F......................-pNpp...........LQQASFQHDKEMLpAQlpATppLQpphhpl+puhLhtGGFStoDAuRu....AlsAPhT+s.lDWs...GTRYaAPs......upsTTh.uGtFoss.s.......................................................utssohhospT.sotluuss.ss..................hssosRTpsWlppQN............pslpPahpGAh.phsaVTPPuSp.uSo..........uo..VSTVPcth..Sa.s......FNTcR.PhFA...............................	1	0	0	0
+4269	PF00680	RdRP_1		RNA dependent RNA polymerase	Bateman A	anon	Pfam-B_32 (release 2.1)	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.51	0.70	-6.25	39	14992	2012-10-02 12:54:00	2003-04-07 12:59:11	15	154	6054	160	0	11808	1	228.60	22	27.06	CHANGED	l.....shss+stlptsshcshhssh.....pcPusLshtDPRhssth...........schths+thhph.h.tplssh.hpshpcshstlhphh.shshtphshtpshpsl........hcsLs.......hsTSsGhPYh........ttKK+chhsptsts........................................th...hhhpshphhtsp.hu.thlhhsslKDELRsh-Kl..................................ptsKTRhhpusPlssslss+hthsshssthhpp.shphshsVGhs..pttWsclhtpLsp..uphhhssDaSsFDuoloPhlhssl..hplhpphh........hphhpshhhphlssshthhcsplh..........clpsGhPSGpssTslhNolhs.lhhphshhchhtshphpp..................p.lc......hhs.YGDDhlluhs.phs.h.....hptlpp..............phtc.hGlphT...sDKops.......hpplsFL+Rph..phspsh...hhshhcpcpIhs.lp..Ws+sspspp.......................plpslshthhcs....spchh.p..clpchhtphlpttsht............Phhtphthcah.t	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..h................h.h......t....h........................................................................................h.........p.............h......l..............s....h....h..........h.t..s..h.h..........................h..tG..P..S.G.ssTo..No.hhp...l..h....h....h....h..t.....h.........p.h...h...............................................................hh....uDD.h....................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+4270	PF00978	RdRP_2	RNA_dep_RNApol2; 	RNA dependent RNA polymerase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_13 (release 3.0)	Family	This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins:     2A protein from bromoviruses     putative RNA dependent RNA polymerase from tobamoviruses     Non structural polyprotein from togaviruses	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.43	0.70	-5.80	36	2606	2012-10-02 12:54:00	2003-04-07 12:59:11	16	43	501	0	2	2727	0	250.60	22	29.18	CHANGED	psDhsls.lc..csplp.oc.psh..p.....pcshhtPslRous.p.....tRpsThp-s..LhAhpKRNhssPcLpcssshpphup.plscpFh..cshhspchhc........sshhss.tthspahsphpshptttl...ts.shhsL.pt...lshppYpaMlKsDlKshl-sohph..EhsssQTIsaacKhlsuhFuPlFpplscRlhtsLps.+llh.ssh....hss.hhscphphhss...hps......lElDhSKFDKSQschHthsphtlhctLGlss.lhsh.Wp.sh.......ccpohl.....p...Dhps..Glth.l.aQp+o..GsshTahuNT...l...lshshlupsh..s..lp...psphshFuGDDSLl...hshps...ts.spthsohaNhEsKlhc....h....sh....PYFCuKFLl..p..ss..sss.....hh.VPDPlKhlhKLGpcchhc.....phLp-hapShsDth+.a.c.hshhphhphshhchh+h..th.tshtsltphl.tuhstapsh	............................................................................................................................................................................................................................................................................................................................................................................................................................l...hpp...hhshaushh+.ltct.l....t.h..L..s...phhhhssh.........s..h.s.th.h.tsht........t.s.....hEsDastFDpo.Qsph......h.h.t.hEhhlh.......c.t.h..G......h......sp....llc........................h.....................t............h....oG...Th.hNT.........hs.hh....h....h....hh..........ht.........t........h...hh..GDD.hh....................................................................................................................................................................................................................................h..................................................................................................................	0	0	1	2
+4271	PF00910	RNA_helicase		RNA helicase	Bateman A	anon	Pfam-B_11 (release 3.0)	Domain	This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.37	0.72	-3.87	99	3937	2012-10-05 12:31:08	2003-04-07 12:59:11	17	83	1135	0	26	5004	845	96.30	36	6.53	CHANGED	lhlhGss.GsGKShhsph.lhptlh...t..................p.sslYs.tsssscaa.sGYp..tQslslhDDhspss.ss....p..htthhpllsossa.lsMAslccKu.h.FsSphllsooNh	.....................hlpGsP.GsGKShhssh.luptls.....................................t.s.sss.Y.......hs...s...c.s...ca.....a.....D.....G....Yc......t...Q.t...V..Vlh.DDh..s..pss...ss..........p...Dhphht..ph.l........soss...ahs.shAul.Ep.....KG...h.Fs.Sc.hllsooN......................................................	0	12	14	23
+4272	PF00940	RNA_pol		DNA-dependent RNA polymerase	Finn RD, Bateman A	anon	Pfam-B_1108 (release 3.0)	Family	This is a family of single chain RNA polymerases.	22.00	22.00	22.10	24.60	20.80	21.90	hmmbuild  -o /dev/null HMM SEED	405	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.45	0.70	-6.00	94	680	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	462	20	294	684	441	385.90	35	41.81	CHANGED	u+sL.GppGLcWLKlalANla....GhDK.hSh.........p-Rlpasc..cp..h..................cpIhcsA........cs.................................................................................Plpt....p.......aWhp......A-cPaQhLAsChElpps....h.....cpsss..ppa.....hSplPlaQDGoCNGLQHYAALGtDhhGAppVNLhP...u-..c....PpDlYotVuphVpctlp.....p-.................................................stpspphuphl..pst......lsRKllKpoVMTpVYGVThhGuppQlpcpLppht...p....................................................................................................................................tt.hhpsupYluphlhpulpphFsuAcpI.pWLspsAphlsp.ssps................................................VhWsTPhGLPVsQsY+...ctppp.plpos....lpshshpps.stsss..........sppKQt.................sAhsPNFlHSLDAoHhhhouh..pstc.......tslsFuuVHDSaWTHA...........ssl-p.MspllR-pFlclaup.s.llpcLtppappphtp................................................................................................................................................................................hphsslPppG.......s.hDlp...........plhcSpYFFs	.....................................................+.L.G..pGl.pWLKlHluNhh..........G..h.cK...hsh.........pcRhtasp..pp..h....ppI.hc.SA..pp.................................................................................Plps..pp.........WWhp.....A-cP..aQhLAsChEltpu....h.....cp.s.s.P..tpa........hSplPlaQDGoCNGLQHYAALGtD.hGAptVNLhs..............u-.p....PtDlYstluph.Vpphhp........p-..............................................................tttst.h...Aphl........tshlsRKllKpoVMTsV.YG............VT....hhGupp..Q.lt.cp.Lpph............................................................................................................................................tt.hhtsupYlsph.hhpu...ltphFpuu..ptl....pW...L.s.p.sA.ch.......lsp.p.ps...............................................................................................................................VhWsTP.l.GlPVhQs.Yp..p.t....p.p....tl.pss..........h.ps.h.hh.p....t..t.h...............................stpKQt............................................suhsPNFlHSLDuo...Hhhhoul.tstc................tsl.s.Fs.u.VHDSaWTHA...........sslsp.hsp.llR-pFlplasp...sllppLh.pph......tph.t............................................................................................................................................................................................................................h..hPtp.G.......s.h-lpplhpS.YFF......................................................................................................................................	0	102	176	254
+4273	PF03118	RNA_pol_A_CTD		Bacterial RNA polymerase, alpha chain C terminal domain	Finn RD, Bateman A	anon	Pfam-B_172 (release 3.0)	Domain	The alpha subunit of RNA polymerase consists of two independently folded domains, referred to as amino-terminal and carboxyl terminal domains.  The amino terminal domain is involved in the interaction with the other subunits of the RNA polymerase.  The carboxyl-terminal domain interacts with the DNA and activators.  The amino acid sequence of the alpha subunit is conserved in prokaryotic and chloroplast RNA  polymerases.  There are three regions of particularly strong  conservation, two in the amino-terminal and one in the carboxyl- terminal [2].	23.80	23.80	23.80	24.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.94	0.72	-4.56	121	5961	2012-10-03 02:11:09	2003-04-07 12:59:11	10	30	5358	22	1041	3553	2145	65.70	44	20.39	CHANGED	ppp.p..p...phhphsI--L-LSVRuhNCLK+ssIpTlu-Llphocp-Lhcl+NhG+KSlcE...IpctLpc	..........................c....php.lLhhsl--..L.-.Lo..VRShNCLKp..t.sIphluD...Llp..+...oE....s...-....LhKscNhG+KSLpE...lKchLt................	0	373	707	891
+4274	PF05066	HARE-HTH	RNA_pol_delta;	HB1, ASXL, restriction endonuclease HTH domain	Bateman A, Aravind L, Iyer, LM	anon	COG3343	Family	A winged helix-turn-helix domain present in the plant HB1, vertebrate ASXL, the H. pylori restriction endonuclease HpyAIII(HgrA), the RNA polymerase delta subunit(RpoE) of Gram positive bacteria and several restriction endonucleases [1]. The domain is distinguished by the presence of a conserved one-turn helix between helix-3 and the preceding conserved turn. Its diverse architectures in eukaryotic species with extensive gene body methylation is suggestive of a chromatin function. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as  hmC [1]. Bacterial versions include fusions to diverse restriction  endonucleases, and a DNA glycosylase where it may play a similar  role in detecting modified DNA. Certain bacterial version of the  HARE-HTH domain show fusions to the helix-hairpin-helix domain of  the RNA polymerase alpha subunit and the HTH domains found in  regions 3 and 4 of the sigma factors [1]. These versions are  predicted to function as a novel inhibitor of the binding of RNA  polymerase to transcription start sites, similar to the Bacillus delta protein [2,3].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.28	0.72	-3.63	67	1524	2012-10-04 14:01:12	2003-04-07 12:59:11	8	24	1377	1	259	816	13	68.90	34	20.55	CHANGED	hoht-sAhpVLcppu....cPhphp-IhcphhcpuLhpht............u+oPtsolsuplhs-hp...........pshFlcl....tsphuLtsh	....................h.ShIElAhslLcp+u.....csMsas-llscI.ps.hhtpp...............spplcspls.pFYT-LN...........hDGpFlslG...-NpWGLRsW.........................	0	72	138	195
+4275	PF04090	RNA_pol_I_TF		RNA polymerase I specific initiation factor	Wood V, Finn RD	anon	Pfam-B_43469 (release 7.3);	Family	\N	19.90	19.90	19.90	19.90	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.48	0.71	-5.04	10	106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	102	0	77	105	0	186.60	21	39.59	CHANGED	hhhs.lspss+cs+tpFllhspGhEVlP..........sshs-l+sa....pppHIspLssLLHlNlLRcNWslAY+hFsLLIRlPsVDIRsIWsLGlEILsplsppsss................cFh-Whsshao...s+ssFspsssp+.hAPVFRoGSRoHTPhYllo.LWslLlpsp.....................................ascLh-+LuEhlLpPPY.sDutlaFlhuhC+llcAs-LuscF	.........................................................................................sp.psh....+hpHlssLoslLHhslhctcaspAhRsaulLl....R......h....p......s....VD....lR..s..h..WulGsEILhptsppsst................................................cahphh.t.has.......tpt...t...............h......................h.h...hh..h...t......................................................................ht.h...htphh...Pa..t..hh.h.u.h.h.......................................................................................	1	20	40	65
+4276	PF01193	RNA_pol_L		RNA polymerase Rpb3/Rpb11 dimerisation domain	Finn RD	anon	Pfam-B_172 (release 3.0)	Domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer.  The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000).  Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037).  Rpb11 is found as a continuous domain.  Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.	18.90	18.90	18.90	18.90	18.80	18.80	hmmbuild  -o /dev/null --hand HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.95	0.72	-4.85	218	7433	2012-10-02 13:35:44	2003-04-07 12:59:11	19	28	6156	190	1663	5625	2992	199.80	31	64.81	CHANGED	lphhhpu.stTluNuLR+hLlsphsslslsshpl.p..t....................................................................................................................................................................................................................................................................................................................................................................................................................................ttpp...............................................................................................hhlclpTs.Gsh........sPpcslpp.AhchLtpphp	...................................................................................................................................-PLE+GaGpTLGNuLRRlLLSS.lPGsAlTplcI-GVhHEaSol.GVpEDVhpIlLNlKtlsl+hpsccpphhplphpGsu.loAuDIhhssslchh....................................................................................................................................................................................................................................................................................................................................................................................s.thhhsshsptsphhhthphptthshssstpscpsptslGhl.lDuhaoPlp+lsYpVEssRVtpps...........DhDKLsl-l.Ts..G.ol...................sPc-Alpt.AA+ILt-pl...................................................................................................................................................................................................................	0	593	1066	1406
+4277	PF02150	RNA_POL_M_15KD		RNA polymerases M/15 Kd subunit	Mian N, Bateman A	anon	IPR001529	Domain	\N	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-8.06	0.72	-4.26	10	723	2012-10-03 10:42:43	2003-04-07 12:59:11	11	10	427	90	486	620	22	35.70	34	27.56	CHANGED	lcFCscCsNhLhspsc+psp....tCRsCsYcp.s-s.	...hpFCscCsNhL.h...s..c..cscpsph.......htCpsCsYpp.h.............................	0	142	257	398
+4278	PF01194	RNA_pol_N		RNA polymerases N / 8 kDa subunit	Finn RD, Bateman A	anon	Prosite	Domain	\N	24.70	24.70	24.70	26.90	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.35	0.72	-3.94	49	498	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	450	97	310	402	203	60.50	55	79.07	CHANGED	MlIPVRCFoC.G+llu.......chWccYhphlpp.....G.s.........ucsLDcLGl.cRYCCRRMlLoH......VD...lI-cll	...................................MIIPVRCFTCGKVlG.......scW-pYlphlps............shsc..........................................u-ALDsLGL.cRYCCR.RMlLoH......VDLI-clL.............	0	101	176	260
+4280	PF04990	RNA_pol_Rpb1_7		RNA polymerase Rpb1, domain 7	Finn RD	anon	Pfam-B_288 (release 4.2)	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases).  This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 forms a substantial interaction with the lobe domain of Rpb2 (Pfam:PF04561) [1,2].	20.80	20.80	21.40	22.10	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.89	0.71	-4.45	42	792	2009-01-15 18:05:59	2003-04-07 12:59:11	7	76	658	90	242	733	168	119.00	55	10.85	CHANGED	TTL+pVTssopIYYDPDPpsTlIEEDp-aVpsaa.-hPD..t.-.s.....phSPWLLRlELDRcthhDKcL.oMpplup+IppsFu......sD.lplIaoDDN.A-cLVlRlRlhpsp...................................ct..-p-p.....c....-D...hFL+clEsphLsslsLp	.................TTLR+VTusTuIYYDP.............DPp.sT...VItEDpEaVslYY.EMPD........hD.so.........+hSPWLLRlELDRK+MsDKKL.TMEpI.A-KIptuFG....................-D.LssIas-sN.....ucch......lhRlRhhttt...................................................t.tpt...........p.....t.....hL+ph.tphLtth.L...........................................................................................................................................................	0	88	139	207
+4281	PF04563	RNA_pol_Rpb2_1		RNA polymerase beta subunit	Finn RD	anon	Manual	Family	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure.  This domain is also known as the protrusion domain [1].  The other lobe (Pfam:PF04561) is nested within this domain.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null --hand HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.23	0.71	-5.40	21	11314	2009-09-13 15:18:01	2003-04-07 12:59:11	10	107	8899	140	1837	8858	4389	301.50	26	35.23	CHANGED	sLlc.Qh-SFstFlppsLp.............-hlpp.sslpspst.............phchplphtplpls.cPphs-..........h.Pp-A+hRslTYSutlYVshchphpps...............................tchpppcValGclPlMhco....h.t....c...htp.....tGhFIlNGsE+VllsQ.hhusshhas.cpcpsuhhshssshhophtttpph.tsppsplht+hspstthshhshhhthths.splhhthhhhth.hph.pphthphptpth....................pthhh.spt.shsthttphhphths+cpphttshphhphphh.+lsstpsscptpshhlshhhphLlhhphshtp.DDhDHhuN+RlchsGpLLps.F+hhhp+Lp+sl+pphptshpcs..........hs.pshlpu.psIosslcphhuou	............................................................................................................................................................................................................................................................................................................h...............................................................h....h....t........h........s..h........................................-s...........cs.hsa..ts.lh..h.hth.....t..................................................................................................p.t.h.....h.G.p........hPhMh..................................................................................................................................................GhFllNG.E+lllsQ.hhusshhh..t.tt.t...h........................h....t......h...hh.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....hh..h.hhh.h....h..DDhcphss+Rlc.su-Llp..sp...a..R.....h....u...L.s...R...hp...+........s.V.+c.ch...s...t..t..s.cs.....................................hs.P.p..p...hI.....s.....h....+....s....lsuulKpFhuou.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	649	1155	1555
+4282	PF04561	RNA_pol_Rpb2_2		RNA polymerase Rpb2, domain 2	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure.  This domain is also known as the lobe domain [1].  DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble [1].  Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.11	0.71	-4.88	22	13001	2009-09-11 22:08:18	2003-04-07 12:59:11	9	96	7019	145	2482	9371	4016	126.70	21	18.82	CHANGED	psstlhhppchspssh..................thhssshhptputhhphchstpthhhsh.phppcIslhllh+AlGh.sDp-Ilptls..a..............s..hh.hhh.phpct.sh.op-pALphltp.......hht.sc.splptupchl............t.lt+.pls.+lshp.s.csp...ps..lhhhlctLltht.hshtp.DDhDHhuN+Rlc	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t....................s........h.t..........................................................................................................................................t......h...p.l.......................................t.....................................................................................................................................................................................................................................................................................................................................................	0	840	1548	2077
+4283	PF04566	RNA_pol_Rpb2_4		RNA polymerase Rpb2, domain 4	Finn RD	anon	Manual	Domain	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain [1].	21.60	21.60	22.30	21.60	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.98	0.72	-4.16	12	7585	2009-09-11 14:40:16	2003-04-07 12:59:11	8	53	5403	96	610	6531	395	61.70	56	13.64	CHANGED	ValNGsllGspcsPccLspplRphRRpGclss..lulhhs.cpp-l+I.TDuGRhsRPLlIV-N	............lFVNGVWlG...V.H.p.....DP..t...pLVpslpcLRR...+..........s.................l......s..........h....EV.Sl..l..R..DI.....R.....-..........RE.....h+IaTDAGRVhRPLFlV-.........................	0	212	356	512
+4284	PF01191	RNA_pol_Rpb5_C	RNA_pol_H; 	RNA polymerase Rpb5, C-terminal domain	Finn RD, Bateman A	anon	Prosite	Domain	The assembly domain of Rpb5 [1].  The archaeal equivalent to this domain is subunit H.  Subunit H lacks the N-terminal domain.	21.30	21.30	21.70	22.10	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.23	0.72	-4.39	64	636	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	504	98	378	576	240	72.50	49	38.79	CHANGED	lNlscHpLVPcHplLoc-EtpplLpcYplc.pQ............LP+IhtoDPls+hh......Gh+.GsVl+IhRcS...pTuGchlsYRlVl	.........................lNITcHpL.VP.c.HhlLopE.EppcLLp+...Y.cl.+.-.sQ..............................LPRIptsDPVA+Yh.......................Gl++G..pVVKIlRp.S...E.TA.G+YloYRlV...............	0	129	223	317
+4285	PF03871	RNA_pol_Rpb5_N		RNA polymerase Rpb5, N-terminal domain	Finn RD	anon	DOMO:DM07083;	Domain	Rpb5 has a bipartite structure which includes a eukaryote-specific  N-terminal domain and a C-terminal domain resembling the archaeal RNAP  subunit H [1,2].  The N-terminal domain is involved in DNA binding and is  part of the jaw module in the RNA pol II structure [3].  This module is important for positioning the downstream DNA.	21.00	21.00	21.00	21.20	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.06	0.72	-3.58	36	436	2012-10-11 20:44:43	2003-04-07 12:59:11	9	10	315	91	270	395	9	95.30	34	42.69	CHANGED	Mssp.......cpht.RLaRshRTlhEMlcDRGYhl..spcElsholcpF+ppasc..............pspRschph.sp.psc...................ssspIaVhFs....-psplGlKsl+sasp.php	..................c...pEhh.RLaRhp+Tlh........p..Mh+DRGYhV..spcEl...s..o...L-cF+ppau-t.t......................pPpRpcLsh.ssps.s-....................sssplaVhFs....--sp....VGlKsl+taspph..............................................................................................................................	0	97	154	223
+4286	PF01192	RNA_pol_Rpb6		RNA polymerase Rpb6 	Finn RD	anon	Prosite	Family	Rpb6 is an essential subunit in the eukaryotic polymerases Pol I, II and III. This family also contains the bacterial equivalent to Rpb6, the omega subunit.  Rpb6 and omega are structurally conserved and both function in polymerase assembly [1].	20.60	20.60	20.80	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.43	0.72	-4.22	57	4597	2009-01-15 18:05:59	2003-04-07 12:59:11	17	6	4471	137	1177	2396	1900	54.00	32	56.84	CHANGED	cclhshhss+YclshllupRAcp..lp.hsssshl.pcsp....+PlhhAlpElscshhp.pl	..............pchlc+lss+apLVllAA.+RARQ...........lp..t..G...t...s..........sh..lt...tpss.................KssshALcEIt..pshls........................................	0	378	740	987
+4287	PF03876	SHS2_Rpb7-N	RNA_pol_Rpb7_N;	SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397	Finn RD, Anantharaman V	anon	Hand	Domain	Rpb7 bind to Rpb4 to form a heterodimer.  This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation[1].  This family includes the homologs from RNA polymerase I and III.  In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA [2]. The N terminus of Rpb7p/Rpc25p/MJ0397 has a SHS2 domain that is involved in protein-protein interaction [3].	20.90	20.90	20.90	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.02	0.72	-3.85	145	1033	2012-10-02 11:08:51	2003-04-07 12:59:11	12	19	491	64	703	949	87	71.80	24	30.62	CHANGED	pchlplsP.phhs...........................................shppslh.......ptLhpphts+.................hstp......h.G..........lllulhcl..pp................lsc....................Gpl..h.sss..GssahpVpachllF	.............................t..hlpltP.phhs............................................phppslp.......pp.L...pch.ts.p.................sstp........h.G...........hllulhcl...pp...lsc....................................GhI..h..sGs.....Gh.s......hhp.......V.pachlVF...............	0	224	387	571
+4288	PF03870	RNA_pol_Rpb8		RNA polymerase Rpb8	Finn RD	anon	DOMO:DM07082;	Family	Rpb8 is a subunit common to the three yeast RNA polymerases, pol I, II and III.  Rpb8 interacts with the largest subunit Rpb1, and with Rpb3 and Rpb11, two smaller subunits.	25.00	25.00	26.50	26.40	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.78	0.71	-3.98	7	366	2012-10-03 20:18:03	2003-04-07 12:59:11	10	4	309	91	251	321	4	131.00	41	90.57	CHANGED	-DIFpVpslDP-GKKa-+VSRlpspSpshc.McLhLDINoplYPlthsDphpLslAooL.h.Dss.ssu....pasP..http.o.hsDpaEYlMYGKlY+lE..Ess..tts.+lu.sYsSFGGLLM+LpGctppLpsFclDpplYLLh++	.............................-DhFsVpslDs...pK..aDR............VSRlpspS.p.s.h.c..hplhLDlNs-lYP.lphu...........D.phplsLAoTL..p.D...G...s.s...-su...................taps........ts.pc...o....hADpa-YVM.aGKlY+.hE.......Ess.....tss..pls.sYsSFGGLLMpLpGshppL..p.s..hclDp.lYLLh++...................	0	84	143	210
+4289	PF05158	RNA_pol_Rpc34		RNA polymerase Rpc34 subunit	Finn RD	anon	Manual 	Family	Subunit specific to RNA Pol III, the tRNA specific polymerase. The C34 subunit of yeast RNA Pol III is part of a subcomplex of  three subunits which have no counterpart in the other two nuclear RNA polymerases. This subunit interacts with TFIIIB70 and is  therefore participates in Pol III recruitment [1]. 	25.80	25.80	25.80	25.80	25.50	25.60	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.02	0.70	-5.25	20	415	2012-10-04 14:01:12	2003-04-07 12:59:11	7	7	320	3	292	406	4	252.70	25	92.27	CHANGED	MAsss........pls-ltpcla-thhpp...sphhoQp-Lpsh..hspsshsplhsslppLl-ppLlcLlp..pssc.Lta+hlsp--ApK..........hsshus-Eu.LVYshI-uoGscGIWs+sI+s+oN...Lppshlp+s........LKoLEo+p....aIKSVKsVchPs+KhYMLasLpPSc-lTGGsWF..oD.p-LDspFIssltphlhpalspKoh.sh........................................................................tptpthshssshpuYsTstplhpalscsu..los.........VpLopcDIppLl-sLlYDG+lEplpss.....t.hpsh+sshpshhph.p.........................................s.hsssshspsPCupCPVFchC..sssusloPcsChYhccWLp	......................................................................................................................................t....................hht.h......t......thh..p.l.t.............p.t.hh.hhp..Lhp.t.hphhp.........tsst..lhaphht..pp.t.tt...............................hpsh....sspEt.llYphIcpuGppGIWp+sl+h+os...L..p.....lp+h........LKsL.Es.+.p....hIKsl+.sVp............ts..p+KhYhLhsLpPs.plTGGsWa..sD.tph-tpFlp.ltp.hhpalpppt................................................................................................................t..h.....s...o.pplhphlpp.t....lsp....................hpLs.pslppllpsLlhDspl-.hh.s...............hh...t.............................................................................................................................................................s..s.h..hp..hP..Cs..CPlhp.C..t.su.l..s..s.ppC.YhppWh......................................................................	0	108	172	245
+4290	PF05132	RNA_pol_Rpc4		RNA polymerase III RPC4	Wood V, Finn RD	anon	Pfam-B_18856 (release 7.7)	Family	Specific subunit for Pol III, the tRNA specific polymerase.	22.10	22.10	22.60	24.40	21.30	22.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.57	0.71	-4.16	36	332	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	269	0	241	326	2	126.50	25	30.42	CHANGED	.csphalhQlPshLPshhsssssp...........................................pptpcsppspppppsspptpssspt.......hppl........pGplGKlhl+KSG+lplclG.slshD.........................lshGssssFLQ-llslss..........tcps................phhsLGplptKhllTP-h	...............................p..tphhhhQhPshLP.h..stt.t.........................................................tt.tt....tt..p.t..pt..ttp.t.stpt................s.sh.pph......................spG.tlGKlhl+KSG+lplpl.........G..s.......lhhD................................................ls....hG.s...ss...sFlQ-llslst.....................cps..............................phhs...LGplpp.+.hlsoPch......................	1	76	128	199
+4291	PF03431	RNA_replicase_B		RNA replicase, beta-chain 	Finn RD	anon	Pfam-B_4422 (release 6.6)	Family	This family is of Leviviridae RNA replicases.  The replicase is also known as RNA dependent RNA polymerase.    	25.00	25.00	25.00	25.00	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-13.04	0.70	-6.30	6	321	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	25	10	0	316	0	252.20	52	80.15	CHANGED	lhspsslt.slus-Lh.shs...........ShuhsuhD.ssDsFc.lsYL+sElLoKa-sauhG.-s....culAatKFLsAEpcCtlpNpchahh.sasEp..hShuEusI+hu.RphIu+LLu-.ssh.shhc+CRFSGGAopsssRpautPuhKaAt.....ptslTsRAlcYshAh+cssu...........s-s+hhclsssN+ssTVPKNuKsDRsIAhEPshNMahQhGlGuhIRcRLRphGIDLNDQTlNQcLAppGSlsssLATIDLSuASDSISlcLVc.LLPPcaachLhcLRSshGhl.DG+llpaEKlSSMGNGaTFELESLIFAAlARSlspllthcsuslulYGDDIIlPocssssLh-VhpaVGFpPNp+KTFosG.PFRESCGKHYFpGVDVTPFYI++sIssLsDLhLlLNplhRWuTlsGlhDPRsasVapKYt+hlP+hLptss...PDsYusuAhlstshhsshstp+tasRhhshlhchtR.h...............chs-hhSYha-hhuch.shhcsu...ss.hs.tps.hhh..t.hp+...h....sots.uhhcshssSc	................................................spDL..thh...h.......uhs.sphD.pscsFp.lsYL+sElhoKasshs.u.sp...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+4292	PF01876	RNase_P_p30	DUF53; 	RNase P subunit p30	Enright A, Ouzounis C, Bateman A, Dlakic M	anon	Enright A	Family	This protein is part of the RNase P complex that is involved in tRNA maturation [1].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.49	0.71	-4.97	62	477	2012-10-03 00:45:34	2003-04-07 12:59:11	11	9	410	3	326	499	10	141.70	25	49.82	CHANGED	hsRlslhhsss....h.....tptlsphpp....taDllulpPtspcshphAspsh..c......lDllohshst...+hshhlc+hhhphAhc+Gl.tlElsaushl...................ps..shsRpphlssh..ppllphs+p..pslllSSuApshhplRuPhDlhsLst.hh...G.....lspscucpuls.p.	.....................................hpRlslh.hsss...t.t........ttths..phhp....ta..DllAlpPts....pchhphAspsh....c.....................lDllshshst......+hs.h.h.............hc.+hh.l.ph..Alp+Gl.thElsaushl..............................ts..sttRpphls...ss............tplhphs+u...........+slllS..SsAp..p...............h..plRuPhDlhsL......ht.lh.G.....lspppuptuls...........................................	0	104	184	268
+4293	PF01900	RNase_P_Rpp14	DUF69; 	Rpp14/Pop5 family	Enright A, Ouzounis C, Bateman A, Cerutti L, Dlakic M	anon	Enright A	Family	tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule associated with at least eight protein subunits, hPop1, Rpp14, Rpp20, Rpp25, Rpp29, Rpp30, Rpp38, and Rpp40 [1]. This protein is known as Pop5 in eukaryotes.	21.50	21.50	22.20	22.00	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.35	0.72	-4.13	65	500	2009-01-15 18:05:59	2003-04-07 12:59:11	14	16	381	7	356	486	8	109.40	22	67.85	CHANGED	RYllhcllh....................................sslsp.....................c.slhptl+pulpphaG-hGsups....sstlhshahss.oth.....uIlRssRsthchlhuuLshlsplss...................ptlhlcsltlSG...TI+psccthlch	...................................................RYlhhplhh...................................................plst......................p.slhphlcpultphaG-hGsuts....................t.tl..p..l......hh....h....sstTth............sIlR.sp.+pthchlhuuLsh.lsplps..............................psshhpslplSGTl+pspphhh..........................	0	109	192	282
+4295	PF00074	RnaseA	rnaseA; 	Pancreatic ribonuclease	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.	21.70	21.70	22.10	21.70	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.09	0.71	-3.83	108	847	2009-01-15 18:05:59	2003-04-07 12:59:11	15	3	206	473	241	891	0	119.30	33	78.61	CHANGED	ppsshppFppQHls........sss..s..............hCN.phMppt.phhp.t....pCKshNTFlHps..hssVpulCsptsssCp...tppNCapSpsphplTpCplous.st......hssCpYpsoppp+h.lhVAC-sp...........lPVHhD	................................t..othppFt.pQHhs........sss..sp.................hCN.phMpp+.shppt......pCKshNTFlHps..hssVpslC.tp...ts..l.sC+.........ss.pp.NC..apSpsthplTsCclosusp......hPsCpYpss..t.p..p+.a..llVAC-ss...........lPVHhD..........................	0	15	18	39
+4296	PF00075	RNase_H	rnaseH; RnaseH;	RNase H	Eddy SR	anon	Swissprot; SCOP and HMM_iterative_training	Domain	RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-11.40	0.71	-3.81	65	16967	2012-10-03 01:22:09	2003-04-07 12:59:11	19	181	3870	344	1941	16858	2641	121.40	50	20.38	CHANGED	sps.hshaTDGSs.tp...stpu...tAGh.lh.pps...............+..pht.tsls.....tsosQp.uElhAlhtALc.s......ts........ppls.....IhTDSpYl......hp.lhp.......................................sh.p.p.tps....lhs......plhphl...hp.ppp.lhltaV.uH.pGh......s.GNchADcLAppusp	............................................................................s..t.shYs.DGAsspp..............sphG.........pA.Ga...Vs...s+G.................................+......pcs..hsLs..........cTT...NQ.+....s.ELp.A...l.hL...A....Lp...D......SG.............................scVN..........Il..T.DSQ..Ys.....lG.....IIp.........................................................uQPs....c...SE.S.........t.lVN............QIIEpL.............I+...KEc...V..Yl.uWV....PA...H..KGI...............................G.GNE....pVD+LVStGI.R..........................................................................................	0	638	1217	1694
+4297	PF00773	RNB		RNB domain	Bateman A	anon	Pfam-B_1009 (release 2.1)	Domain	This domain is the catalytic domain of ribonuclease II [1].	20.30	20.30	20.40	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.05	0.70	-5.15	86	6644	2009-01-15 18:05:59	2003-04-07 12:59:11	14	56	4239	12	2000	5433	2047	308.20	33	41.36	CHANGED	RpDL..pch........hhh.oIDsts.scD....hDDAl................plcphs.sGt............................aplhVHIADVopalp.s........oslDp.cAtpRus.........................olYLssp.slsMLPppLu..p....slsSLtssp......................................c.Rhshoshhpl.spp.Gp.......l.ts...hchttulIcspt+loYcplpphlpsttpt.......................................tppLptLh....p.luptlcppRhpp.........Gulph.s.hs....-h.................................ph.l.....................sp......pspshshhhhp.....................ps.ucpllcEhMlhANpssApal.......t.pp..thsslaRspstPs.p........th.phhphh.........................ht..ttt...........htphht........psp..p.hl.......phhlh+sh...ppupY........sspsh.............HauLuh....stYo+aTSPlRRYsDLlsHR.LpthLpp	..........................................................RhDL...Rsh...hh.TID..s.ts..u+D......hD..D..A..l.........................................................................hs....c.pht....sGt............................acLhV............t...........IADVohYVp..s..................................osLDp.EAh..pRu.s.............................SVY..h.s.........s.....p...s...l.P...MLPcpLS.......s.............slCSL....p...Pp........................................-..Rhshssthpl..stp...Gp.................................l...hs......hc..hh.......pull....c.........S..p.t..+.h..oYspVpp..hl.p...s..p.pp.ttt.................................................................................................lhtpl.p..Lt....p..ltphLp.p.tR.h.p+.........................Gu.lsF..-..ps...................Eh....................................................................................+hh.l..................................sp................psc....p.lh.pp....................................Rp.uc.+llEE...hMlhAN.ssA..chl.....................p...ct........thss.laR.l...H.p.t.Ps.c...........phpphhphlt................................................hhth.ht.t..................................shpphhpt...............htsps...tth.l....................pph.hhR.sh.....ppAtY....................................................................sscsh..s.......Ha.GLuh....................phY..sHFT......SPIRR.Ys.DLllHRhl+thl..t.........................................................................................................................................	0	677	1244	1691
+4298	PF02508	Rnf-Nqr		Rnf-Nqr subunit, membrane protein	Mian N, Bateman A	anon	Pfam-B_1638 (release 5.4)	Family	This is a family of integral membrane proteins including  Rhodobacter-specific nitrogen fixation (rnf) proteins RnfA and RnfE [1] and Na+-translocating NADH:ubiquinone oxidoreductase  (Na+-NQR) subunits NqrD and NqrE. 	20.70	20.70	20.90	20.80	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.31	0.71	-4.71	128	4543	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	1639	0	935	2710	1506	193.80	38	92.91	CHANGED	hp..ph...plhhsulhhsNsllsphLGlCPhLAVosplpsAlGMGlAsshVlshSshhlull+phl..........................................stlRl.saIhlIAuhVpll-hl...lcu......as..sLYpsLGIFlPLIsTNChlL........GRA-hhAp+................pshhtShlDG.lGsGlGFslsLllluulREhlutG..shh....t..................s.sh.pshslhllssG....AFhshuhllt	................................................................................................pchhplhlsslhhNN.sLlp..hLGlCP.hLA.Vo.pplp..sAlG.hGlAsThVlsloshsspLlcpal...........................shl..Rhlsal.hlIAulVph.l-hl...lct.au...sL..Y.ps..LGI...FlPLIs...TNChll........G.tA....hhsp+...................p.shhpShl..G.husGlGaslslllluulRE.hlusus..l..........................stsh...pshsl..sh..lssG........A.Fhuhuhll.h..........................	1	309	603	792
+4299	PF03259	Robl_LC7		Roadblock/LC7 domain	Mifsud W, Bateman A	anon	Aravind L	Domain	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	22.20	22.20	22.20	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.46	0.72	-4.42	41	1879	2012-10-02 21:07:43	2003-04-07 12:59:11	12	15	656	43	934	1705	25	90.00	22	65.84	CHANGED	hs.hlhphhtpssulpsslllss-Glslst.....shssscscplAAhsuulhuhuctsspphs..ssplcphhlcscpshlhlsssus...tshL.slls	..............................h.phh.p.p.ssG.lptsllls.s..D....G..lhlss.................sh.sp.s..s.u..........-....p..........l.AA.l.s...u...ul.h...uh.ups.....su.......pphs.......t........ss....lp.phhlchcp.....u.h.lh..lhss..uc....tshL.slh....................................	0	317	624	826
+4300	PF00480	ROK		ROK family	Finn RD	anon	Prosite	Family	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.99	0.71	-4.45	14	15339	2012-10-02 23:34:14	2003-04-07 12:59:11	15	52	3744	43	2992	10332	2028	179.30	24	53.05	CHANGED	ulDlGuT+lthslhs.suplltpcchsT.....ssspthlsslsshlpch.sphs.......ululussGhlspsp......hlshsPp..hshtc.hslhpplcpchslPVhlpNDANsuAhuEphhssupshpshlhloluTGlGuGllhss+lapG.spG.AGElG...Hhhhs.p...........t.hCsCGpp.GClEshASGpAl	.......................................................................................................ulDlGuo.p.l...p.....h..u..l....h.....s................s............u........p........l....l....t......c.....p.....p......h..s.ss.............pss....p....p....h...l....p....t....l....h....p.....h..l....p....p....h.h..t..p...ht..........................ul.G.lu.hP......Gh..lc....p.p................sh.l...h...t...s..s.p.................s.a....p.......s....h....s..........l...t....p.....t....L.........p........p........p......h............s............l...........P........l......h...l.p....ND..ss..s...s..A......l...u......E.............h.............h.............h....................G.............s.............u.......p.....s.....h..........p........s.....h.l......h..l.............s.............l.............G............T...G.....l.....G.u..Gl....l...h.......s.G...c.....l.h...p..G...t......ps..tu..G.E.lG.........H.h..h..h..s....t......................................t.....C....C..Gp......h...G..ClEshhut.s.................................................................	0	1016	1988	2532
+4301	PF02027	RolB_RolC	Glyco_hydro_41; 	RolB/RolC glucosidase family	Bateman A	anon	Bateman A	Family	This family of proteins includes RolB and RolC.  RolC  releases cytokinins from glucoside conjugates [1]. Whereas RolB hydrolyses indole glucosides [2].	21.30	21.30	25.80	22.50	18.50	21.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.15	0.71	-5.13	41	119	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	15	5	14	115	0	190.50	20	62.83	CHANGED	hspstapsh.slphlpssp.cLctpLppAhpsapshhppslh.htpthh..h..............................t.hs.-hhh.spphhYlYssppphpphhp.s+hlspsu.spullAsslPPYppslohtthhphhNpls.........hsspps.pchsaFlAl.hPsssFhct.phplpstpst.hhhsFaspp..............................ss.hsa-.l...lAhGcshh	......................hshapsh.clphlpstt.cLptpLppAhpsacshhppslh.h.pth.....................................................h.hs.-hhh.stphlYlYssppthpphhp.p+.ls............pss.tpullAsslPPYppslohtphhphhNpls..........sst..psspchsaFlAl.hPossFhch.ph.lpstp.stphhhsaaspp...............................st.hsa-.l...lAhGpshh...........................	0	8	14	14
+4302	PF01815	Rop		Rop protein	Bateman A	anon	PSI-BLAST	Domain	\N	21.20	21.20	21.20	51.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.01	0.72	-4.52	12	216	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	168	35	7	146	14	57.70	73	91.23	CHANGED	MTKQEpsALNMAKFI+uQo.LLLLEKLspLD...LDccAs.CE+LHEpAEpLappLusRlt.p-.p	MTKQEKTALNMARFIRSQT.LTLLEKLNELD...ADEQADhCEpLH-cA-ELapSh.sRFts-sp....	0	1	3	6
+4303	PF00980	Rota_Capsid_VP6		Rotavirus major capsid protein VP6	Finn RD, Bateman A	anon	Pfam-B_1047 (release 3.0)	Family	Rotaviruses consist of three concentric protein shells.  The intermediate (middle) protein layer consists 260 trimers of VP6.  VP6 in the most  abundant protein in the virion.  VP6 is also involved in virion assembly, and possesses the ability to interact with VP2, VP4 and VP7 [1,2].	25.00	25.00	33.60	40.00	24.50	17.70	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.15	0.70	-5.83	3	1454	2009-09-11 12:38:02	2003-04-07 12:59:11	12	1	356	40	0	791	0	234.90	80	99.79	CHANGED	MDVLYSLAKTLKDARcRIVEGTLYTNVuDIIQQsNQlIsTLNGSTFQTGGIGNLPlRNWsFDFGpLGTTLLNLDANYVENARTTIDYFIDFIDuVClDEMVRESQRNGlAPQS-oLRpLAuuKFKRINFNNSSEYIENWNLQNRRQRTGYlaHKPNIFPYsNSFTLpRSQPtHDNlMGThWLNsGSEIQIAGFDSoCAlNAPuNIQcFEHlVpLRRsLoNATloLLPsAPRlopPsVIPoADGtTTWLFNPVILRPNNVpVEFLLNGQlIssYQARaGTlsARNFDSIRISFQLlRPPNMTPuVsALFPQAuPFsHHATVGLTLRIESAoCESVLuDANEshLSIVTulRQEYAIPVGPVFPPGMNWTELLoNYSsSREDNLQRlFTVASIRSMlI	...........................................................................................................................................................................................................................................................sstTTWaFNPlIL..RPNNVEVEFLLNGQIINTYQARFGTIlARNFDTIRLSFQLMRP..P..NMTPAVsALFPQAQPFp.HHATVGLTLRIESAVCESVLADAsEThLANVTuVRQEYAIPVGPVFPPGMNWp............................................	0	0	0	0
+4304	PF01525	Rota_NS26		Rotavirus NS26	Bateman A	anon	Pfam-B_762 (release 4.0)	Family	Gene 11 product is a non-structural phosphoprotein designated as NS26 [1].	21.10	21.10	21.50	21.10	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.45	0.70	-4.55	6	556	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	255	0	2	356	2	185.60	87	99.47	CHANGED	MSDFGIN...LDAICDNV++spSsScTuSQlSNRSSR+MDFV..D-EELSTYFNSKu..SVTQSDSCSNDLssKaSIIoEAVlCDESAHVSADAlQEK-Eo....lsQlDaslMKWMhDS.DGIslNGGlNFo+uKSKsp....................cpEschT-.KScTNl.sasSlsIsSslGtFNPIppplKhEAls-hFEDEDs-sChC+NCPY+EKYhKLRpRMKsVLlDhIsEM	...........MS.LSIDVTSLPSIS.SSIFKNESSSTTSTLSGKSIGRSEQYISPDAEAF.NKYMLSKSPEDI.GPSDSASNDPLTSFSIRSNAVKTNADAGVSMDSSTQSRPSSNVGCDQlDFSLsK.......GIsVsANLDSCI.SISTsp....................KKEKSKKD.KSRKH...YPRIEADSDSEDY..............VLDDSDSDDGKCKNCKYKKKYFALRMRMKpVAMQLIEDL...................	0	0	0	1
+4305	PF02509	Rota_NS35		Rotavirus non-structural protein 35	Mian N, Bateman A	anon	Pfam-B_1677 (release 5.4)	Family	Rotavirus non-structural protein 35 (NS35) is a basic protein which possesses RNA-binding activity and is essential for genome replication [1].	25.00	25.00	120.20	120.00	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.02	0.70	-5.71	3	493	2009-09-11 00:14:00	2003-04-07 12:59:11	9	1	240	7	0	353	0	301.10	90	99.67	CHANGED	MAELACFCYPpL-cDus+ahPaN+pAIKCMLoAKVDKccpSpaYDTIlYGlAPPPpFKKRFNTs-NSRGMNYETDMYsKVAsLLs-lLNuIKlsp-K.sA-IlusVISVRHLENLlLRIEN+DDILScsscLllKSVLIAhGLlKEsETTsTAEGGEIVFQNuuFTMWKLDYpSH+LMPIhDsNFlEYKITlNccsPIsD+cV+ELlAELRWQYNKFAVITHGKGHYRVV+YSoVANHADRVYuTFKSspK+GssacFN-LDpRlIWsNWtAFluSMpsGsTLEluK+LLFoKMK.sSsoFKGlTT-RKhDEVShlG	...MAELACFCYPHLENDSYKFIPFNsLAIKCMLTAKVDKKDQDKFYNSIVYGIAPPPQF+KRYNTsDNSRGMNYETsMFNKVAlLICEALN.SI.KVTQS-.VANVLSRVVSVRHLENLVLRKENHQDVLFHSKELLLKSVLIAIGQSKEIETTATAEGGEIVFQNAAFTMWKLTYLDHKLMPILDQNFIEYKITLNEDKPISDlpVKELlAELRWQYNRFAVITHGKGHYRVVKYSSVANHADRVFATYKNNsKSGNshDFNLLDQRIIWQNWYAFTSSMKQGNTlDVCKKLLFQKMKQEKNPFKGLSTDRKMDEVSHVG....	0	0	0	0
+4306	PF00981	Rota_NS53		Rotavirus RNA-binding Protein 53 (NS53)	Finn RD, Bateman A	anon	Pfam-B_1048 (release 3.0)	Family	This protein is also known as NSP1. NS53 is encoded by gene 5.  It is made in low levels in the infected cells and is a component of early replication.  The protein is known to accumulate on the cytoskeleton of the infected cell.  NS53 is an RNA binding protein that contains a characteristic cysteine rich region [1].	22.10	22.10	24.10	24.10	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.89	0.70	-5.84	14	573	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	251	0	0	494	0	455.80	70	99.18	CHANGED	MATFKDACaHY++lsKLNptlLKLGANssWRPuPssKhKGWCLDCCQaT-LTYCpGCoLaHVCQWCsQYsRCFLDsEPHLLRMRTF+ssITKEDLpsLIsMYshLFPINc+IVsKFhsslKQ+KCRNEahhpWYNHLLhPITLQALslcl-.sclYYIFGYYDsMsptNQTPFpFVNhIshYD+LLLDDlNFcRMuhLPssLQppYAhRYFSKSRFlSpph+plphSDFScphlp.spcsPspthplhRNsop.......hcWNcpCc....LlpstpsYhshhpTSapEpYsVSspshhasptKLphlS+hhKPNYlsSNHtpsAocV+sCKWCslsssapsWpDFRl+clYNslhsFIRALhKSNsNVGHCSSpEplYthl+slhhhspscpaspolpplFshL-PV-lssscYlLhsaplsa-lhsllhpslpsc.lPpILols-htsIlpuII.cWFDlchMRchPhsstoTscL+cLpccscLs-EYDhhlSDsE	....MATFKDACYaYKRINKLN+sVLKLGVNDTWRPSPPTK..YKGWCLDCCQHTDLTYCRGCTMYHVCQWCSQYsRCFL..D..s-PHLLRMRTFKNEVTKsDLhNLIDMYshL....F....PINp+IVsKFIssTRQHKCRNEChsQWYNHLLMPITLQSLSIELD.GDVYYlFGYYDsMpslNQTPFSFsNLlDhYDKLLLDsVNFsRMSFLPssLQQEYALRYFSKSRFISEp.RKClsD.HFStNVlE.NLHNPSFKlQITRNCSE.....hSs-WNtACK....LVKshssYFslLKTSHlEFYSlSTRCRhFTQaKLKlASKhIKPNYlTSNH+TsATEVHNCKWCSINNuYpVWNDFRlKKIYDNIFNFLRALVKSNsNlGHCSSQEKIYEalcDVLsVCD-E+WKhuVscIFNCLEPVELssVcYVLFNHElNWDVINlLVQSl.GK.VPQILTLsDllhIhpSIIYEWFDIRYMRNTPMTTFTlDKLRpLpTtsKTV.-YDSGISDVE................................................................................	0	0	0	0
+4307	PF04866	Rota_NS6		Rotavirus non-structural protein 6	Mifsud W	anon	Pfam-B_4831 (release 7.6)	Family	\N	25.00	25.00	45.80	45.80	19.10	17.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.30	0.72	-3.98	12	253	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	198	0	0	89	0	91.00	90	99.27	CHANGED	MN+L.QRQLFLENLLVGVNSTFHQMQKHSINTCCRSLQRILDHLILLQTIHSPAFRLDRMQLRQMQMLACLWIHQ+NHDLQsTLGAIKWISP	.MNRLLQRQLFLENLLVGVNShFHQMQKHSINTCCRSLQRILDHLILLQTIHSPAFRLDRMQLRQMQhLACLWIHpHNHDLQATLsAIpWISP.....	0	0	0	0
+4308	PF01665	Rota_NSP3		Rotavirus non-structural protein NSP3	Bashton M, Bateman A	anon	Pfam-B_1010 (release 4.1)	Family	This family consist of rotaviral non-structural RNA binding protein 34 (NS34 or NSP3). The NSP3 protein has been shown to bind viral RNA.  The NSP3 protein consists of 3 conserved functional domains; a basic region which binds ssRNA, a region containing heptapeptide repeats mediating oligomerisation and a leucine zipper motif [2]. NSP3 may play a central role in replication and assembly of genomic RNA structures [2]. Rotaviruses have a dsRNA genome and are a major cause cause of acute gastroenteritis in the young of many species [1]. The rotavirus non-structural protein NSP3 is a sequence-specific RNA binding protein that binds the nonpolyadenylated 3' end of the rotavirus mRNAs. NSP3 also interacts with the translation initiation factor eIF4GI and competes with the poly(A) binding protein [3].	25.00	25.00	53.30	53.10	24.50	24.10	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.84	0.70	-5.45	6	508	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	241	10	0	389	0	266.80	87	89.08	CHANGED	EoTQthspSIlNuuF-AAlsussSsL-phGIpYDas-.VhuRl+sKachlhDDSGVpNNhIGKAtTIDQALssKhuSAtRNcNWhTsspTlARLDEDVN+LRhMLSuKGIDQKMRVLNuCFSVpR.PGKSSSII.......................pCT+LhK-KIERGE..lEV-Dphh-.+M-lDs...IDWKu+a-phcp+FpShtthV...........sEKYssWV.....hKA+KlsEsMhsLQ.sIupQQs+IsE...hphaNpKLp.+s..lps+.sShIuulEWhhpShph-D-l+sDhpQphNolsVINshpulD......DlE	.........ESTQQMVSSIINTSFEAAVVAATSTLELMGIQYDYNE.VFTRVKSKFDYVMDDSGVKNNLLGKAlTIDQALNGKFGSAIRNRNWMTDSKTVAKLDEDVNKLRMhLSSKGIDQKMRVLNACFSVKRIPGKSSSII.......................KCTRLMKDKIERGE..VEVDD.SaVDEKMEIDT...IDWKSRYDQLEKRFESLKQRV...........NEKYNoWV.....QKAKKVNENMYSLQNVISQQQNQIAD...LQQYCNKLE.sD..LQuKhSSLVSSVEWYLRSMELsDDVKsDIEQQLNSIDlINPINAIDDlE.............................	0	0	0	0
+4309	PF01452	Rota_NSP4		Rotavirus non structural protein	Bateman A	anon	Prodom_2202 (release 99.1)	Family	This protein has been called NSP4, NSP5, NS28, and NCVP5. The final steps in the assembly of rotavirus occur in the lumen of the endoplasmic reticulum (ER). Targeting of the immature inner capsid particle (ICP) to this compartment is mediated by the cytoplasmic tail of NSP4, located in the ER membrane.	25.00	25.00	98.70	98.50	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.11	0.71	-4.93	5	1516	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	459	20	0	1040	0	169.00	81	99.03	CHANGED	MEKLTDLNYTLuVITlMNsTL....HNIIp-PGMsYFPYIASVLTVLFThHKASlPTMKlAh+TSpCSYKVIKhVVVTIFNTLLRLuGYK-plToKDElEpQhsRIVKElRcQLcMIEKLTTREIEQVELLKRIYDhLhspsssEIDMSKETN+KsaKTLc-Wu.sKcPY-PT-VlA.s	......M-KLsDLNYTLSVITLMNDTL....HoIIpDPGMAYF...PYIASVLTVLFTLHKASIPTMKIALKTSKCSYKVIKYCIVTIlNTLLKLAGYKEQVTTKDEIEQQMDRIVKEMRRQLEMIDKLTTREIEQVELLKRIHDpLIsRPlDhIDMoKEFNQKNlKTLDEWE.SGKNPYEPpEVTAS..	0	0	0	0
+4310	PF05087	Rota_VP2		Rotavirus VP2 protein	Moxon SJ	anon	Pfam-B_6280 (release 7.7)	Family	Rotavirus particles consist of three concentric proteinaceous capsid layers. The innermost capsid (core) is made of VP2. The genomic RNA and the two minor proteins VP1 and VP3 are encapsidated within this layer [1]. The N-terminus of rotavirus VP2 is necessary for the encapsidation of VP1 and VP3 [2].	25.00	25.00	63.80	63.70	17.90	17.40	hmmbuild  -o /dev/null HMM SEED	887	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.69	0.70	-13.64	0.70	-6.62	3	539	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	239	6	0	403	0	737.00	88	99.98	CHANGED	MAYRN...+RcpNopppDscpEK-sEpQ-..........-K-+pELKEKVhDKK-sVlTD..Ds.pDhK-psss-NLKlsDpVKcSpKE-SKQLlEVLKTKcEHcKEIQYEILQKTIPSFpPcEoILKKLcDIKP-.AKKpsKLFRLFEPKQLPIYRANGEKELRNRWYWKLKKDDLP-GDYDVREYFLsLYsQVL-EMPDYlLLKDMAVENKNSRDAGKVVDSETApICDsIFQDEETEGsVRRFIADMRQRVsAERNTVcYPAILHPIDYEFNcYFLpHQLIEPLTN-lIaNYIPERLRNDPNYILNMDsNLPoTARYIRPsLLQDRLNLHDNFESIWDTlT+ANYVLARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDAFKTIIAsMLSQRTISL-FVTSNYMSLISuMWLMTIVPo-MFIRESLVACQLAVINTIIYPAFGLQ+MHYpNGD.RRPFpIAEQQIsNFQVpNWLHFVNsNQFsQVVIDGVlNQsLNDsIRsG+IINQLMEALssLSRQsFsTYPlDYKRSVQRGILLLSNRlGQLVDLTRLlsYNYETLMACITMNMQpVQTLTTE+LQLTSVTSLCMLIGNsTVIPEPpTLFHYYsoNVNFHoNYNERINDAVAIIsAANRLDLYQKKMKuIVEDFLKRLHIFDVsKVPDDQMYRLRDRLRpLPVERRRlDVFsIILNNMDQIERASDKIAQGVIIAYR-MpL-YDEhYGaVNlARDlNGFQQINLEELMRTGDYuQITNhLLNNQPVALVGAIPFVTDSSVISLIAKlDATVFAQIVKpRKVDTLKPILFKINSDSNDFYLVsNYcWVPTSTTKVYKQVPQQFDFRsSMHMLoSNLTFTVYsDLLsFVsADTVEPINAVAFDNsRIMQEL	...................................MAYRKRGs+..REs...Q.Q..NERLQE.KElEps..sDs.M............p.psNN+.K.QQL.SDKVLSQKEEIITD..............sQDDlKIADEVKKSS.KEESKQLLEILKTKEDHQKElQYEILQKTIPTFEPKESILKKLEDI+PEQAKKQhKLFRIFEPRQLPIYRANGEKELRNRWYWKLKKDTLPDGDYDVREYFLNLYDQILIEMPDYLLLKDMAVE..NKNSRDAGKVVDSETAsICDAIFQDEETEGslRRFIA-MRQpVQADRNlVNYPSILHPIDaAFNEYFLpHQLVEPLNN-IIFNYIPERIRNDVNYILNMDhNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDL..K..E..LVSTEAQIQKMSQDLQLEALTIQSETQFLsGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVlPNDMFlRESLVACpLAIlNTIVYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVAN.WLHFlNNNpFRQVVIDGVLNQsLNDNIRNGpVINQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLuYNYETLMACITMNMQHVQTLTTE+LQLTSVTSLCMLIGNsTVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKuIVEDFLKRLpIFDVsRVPDDQMYRLRDRLRLLPVEhRRLDIFNLILMNM-QIERASDKIAQGVIIAYRDMQLERDEMYGaVNIARNLDGaQQINLEELMRTGDYuQITNMLLNNQPVALVGALPFlTDSSVISLIAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWlPTSTTKVYKQVPQ.FDFRsSMHMLTSNLTFTVYSDLLuFVSADTVEPINAlAFDNMRIMNEL...	0	0	0	0
+4311	PF00639	Rotamase		PPIC-type PPIASE domain	Bateman A	anon	Prosite	Domain	Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-10.28	0.72	-3.25	87	5141	2012-10-02 13:30:10	2003-04-07 12:59:11	16	48	2764	71	1422	7342	3338	93.40	30	34.16	CHANGED	HILltst..................tp.tts....cppupplhpplpsGt.....s.FsplApphS.Dsso...uppGGcLG..h...hsts.......phssp.Fpcslhshp...Gp.lS.tPl.....co..phGaHllcltc	.................................................................................................HILlp....................................t.tts.......cpphpplh....ppl...psGt........................s.Fuc.lA+..pa..S....-...s.s.S........up..p..G.....G-......LG......h...........h.p..s.......................ph.s..st....F....c.....c....s.....l..h.s..hp........h.....Gp.....lo..sP..l...............+o....p.h.G..aHllcl..t..............................................................	0	466	906	1210
+4312	PF03428	RP-C		Replication protein C N-terminal domain	Finn RD, Bateman A	anon	Pfam-B_4463 (release 6.6)	Domain	Replication protein C is involved in the early stages of viral DNA replication.	22.90	22.90	23.00	23.60	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.85	0.71	-4.82	52	484	2012-10-04 14:01:12	2003-04-07 12:59:11	8	4	191	0	102	471	13	159.10	41	44.88	CHANGED	RshThuhltuQhtuppht.ssts.lsKWclaRplscA+shlGlsDRuLAVLsALLSFaPcscL..spcssLlVFPSNtQLuhRApGMusuTLRRHLAsLV-AGLIhR+DSPNGKRYAR+spsGplppAaGFDLuPLluRApElpphAppltA-+pth+th+EclTltRRDltKLIpsuh-E	..............................................t.ht.t..st...t........tt..ssKWplhc.lsc.A+shlGls.cRuLsVLsALLoFaPcs..pl.......s............tp.s...........s..l...l.......VFPSNtQLuhRspGhussTLRRHLAhLV-AGLIhR+D.SPNGKRYARRs..p.s.GpltpAFGFsLuPLlsRut....E.lcthAppltsc+tth+phREplTlhRRDItKLIphuh...........................	0	12	46	66
+4313	PF03055	RPE65		Retinal pigment epithelial membrane protein	Griffiths-Jones SR	anon	Pfam-B_947 (release 6.4)	Family	This family represents a retinal pigment epithelial membrane receptor which is abundantly expressed in retinal pigment epithelium, and binds plasma retinal binding protein.  The  family also includes the sequence related neoxanthin cleavage enzyme in plants and lignostilbene-alpha,beta-dioxygenase in bacteria.	17.40	17.40	17.90	18.30	16.40	17.30	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.91	0.70	-5.94	151	2113	2009-09-10 15:57:50	2003-04-07 12:59:11	10	23	714	11	903	1992	868	396.50	24	89.26	CHANGED	pusassstpEh.sst....thpVp.GpIPspL.sGshhRNG..Ps.h...............ts....hthpHhFDGDGMlpuhpht.......sG...c....sp.apsRalcTptaptEp..psu...c.hlh.u.ht..............................sshps.............................hpssANTsllha...sG..............................+lLAh.hEsu.hPapl-s....toL-TlGh...hs.hs........................stlt.............tshoAHP+hD.PtTG-......lhsFuh......p..s.t.....tshlphhpl........sssG.............t.hhtp.hsh.shs..t..sshhHDFulTcsYslhhp..Plp...hs..thh...hut.......................................pshtacsppssp.htllsR...c....st..........ptl...............phacs.sss.asaHhhNAa....E..t.ts..............cllh-ssph...ssss.hh.............................................tt...t.hp......................tupLtRaplshp...s...............................................................................s.......ps.pp....phls.....pt...sEFPpl...........s.sphsGpp.hRasY.....................................shpsps......................hsulsKh............Dh....ps.......................sp....tp................................haphs.....spasuEPlFVP....ps..............su..........t......tEDDGallshVhct...pp............t...pSp..LlllDAp..shsp..sl..Acl.pLPt.+l..PhGhHGsalss	.........................................................................................................................................................................................tp.............h..l.t..Gp.lP............t.l.pG..hhRsG..s.s.h................................th.HhF......D....G.tu..............hlpthphp..........................................sG.......p.sp..atsRalpopt.hhttt...t.s.........hh.t.ht.........................................................................ht...sssNsslhhh.......ss..............................................chhuh...Ess.....ht...lp...........tsLpThuh..........hs..hp..............................................................s.lt...................shsAHP+.h....D..s....sGp.............................hhshsh.....s...................................shhphhhh......s.ps..................................t..hh.p..h.h....h...t...ssh.hHs....au.l..Tcpa..hl.h.p...slhh.p...thh......ts.............................................ht..ap.....ph...sp.hh....lls+......t...........st.........h............................................th...hcs.......sh....hh.hHhh.........NAa.....E.....ctt..................................pl.lh...hsth...ts.....h...........................................................................................................s.lhchhlsht....s............................................................................................s.......th..pt.....p.lt...........pt...shE.hspl........s....ph..hGp.p.h+asY........................................hht..................................sslh.Kh...............Dh...........s................tp........hp..........................................................ha..s.....s.th...suEPhFVP...ps....................................................su.......t.......tEDDG..hlls.hlhst.......tp...................t..p.u..lhll..DAp.....sh.......pt............lAph..pl..P...pl..PhGh..HGhah..t................................................................................	0	234	534	747
+4314	PF02318	FYVE_2	RPH3A_effector; RPH3A_effect_N;	FYVE-type zinc finger	Mian N, Bateman A, Eberhardt R	anon	Jackhmmer:Q13875	Family	This FYVE-type zinc finger is found at the N-terminus of effector proteins including rabphilin-3A [1] and regulating synaptic membrane exocytosis protein 2 [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.06	0.71	-4.20	21	739	2012-10-03 17:27:21	2003-04-07 12:59:11	11	21	94	8	344	696	0	106.60	29	14.78	CHANGED	SpLTD-EAcHVhpVlQRDhcLRKKEE-RLucLKp+lpcEso++plLusptphs-opCl+ChpPFpFLlNoK..RQClDCchhlCKs.Cupa........sKpEpGWlCcsCphuRll.KhtSLEWaYcsV	..............................................LpctEtchl.pVltRs.phc.phEp.......c.......R..l..t..c.Lpp..c.l.......E.p.h.+.+...th..h............u...p...........t..........p.................s......p...p.....p.........Ch....hCtp...........h....s..hl.hsss........p.CpsCphplC.pp..Cssh............................pppcthWlCslCpc.p..ppl.hhtoGtWFap.......................	0	57	84	185
+4315	PF04390	LptE	DUF532; RplB;	Lipopolysaccharide-assembly	Kerrison ND	anon	COG2980	Family	LptE (formerly known as RplB) is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported from its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptD appears to be anchored in the outer membrane, and LptE forms a complex with it. This part of the machinery complex is involved in the assembly of lipopolysaccharide in the outer leaflet of the outer membrane [1].	23.30	23.30	23.40	23.60	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.01	0.71	-4.48	162	2176	2009-11-10 14:17:04	2003-04-07 12:59:11	7	3	2150	4	501	1407	1106	153.80	20	84.72	CHANGED	hhhhslhlu...uC...Gap.hssh.sh...................shthpslhlpss......pst..s.lpptlpcpLttsssthhsst...............hhLplphp.shsppshshs...tsu......ps..scaplshslpaplt...phsss.....phl......shs...sppsas..hs........ss..sl......upptpcpt..hhcchtpphAppllpclst	................................................h.hhhslllu....uC.....G.a+hpsss.th.........................s.phps.hhlsss...........cs.......s.lsctl....cppL...p....ts.s.sphlspp.pt.................spLclttsshsppshol.......psG....................ps...sEa..plhhslshplh......hssp......chh..........sho........sh+sa......s.............sp....sl..........Aps..sp....pch.....lh..p.ch.tccsucQllppl....................................................	0	147	308	412
+4317	PF04032	Rpr2	DUF363; 	RNAse P Rpr2/Rpp21/SNM1 subunit domain	Kerrison ND, Finn RD, Mistry J, Wood V	anon	COG2023	Family	This family contains a ribonuclease P subunit of humans and yeast.  Other members of the family include the probable archaeal homologues. This family includes SNM1 [2].  It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing.  SNM1 is an RNA binding protein that binds the MRP RNA specifically [2]. This subunit possibly binds the precursor tRNA [1].	22.60	22.60	22.70	22.70	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.31	0.72	-4.11	86	508	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	375	5	347	512	76	95.70	24	51.13	CHANGED	p.RlpaLhphAp............................................................................hst.sspl...u+pYlphhcplup+tplc.ls.p..h...KRphC+cCpshLlPGhssclRlp............................................................psh...llh......pChpCup	...................................................................................................................RlpaLhphAp............................................................................h....t.t..ts.s...pl....uchYsphhcplu..p....+tpl...+...ls.p........h...K.Rp....hC+..pCsshLlPGh.s.s.p.l+lc.............................................................................................................t..tph.......lsh........pChpCs......................................................................	0	97	190	288
+4318	PF01765	RRF		Ribosome recycling factor	Bashton M, Bateman A	anon	Pfam-B_949 (release 4.2)	Domain	The ribosome recycling factor (RRF / ribosome release factor) dissociates the ribosome from the mRNA after termination of translation, and is  essential bacterial growth [1]. Thus ribosomes are "recycled" and ready for another round of protein synthesis.	22.80	22.80	23.00	25.70	21.70	22.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.75	0.71	-4.78	133	4805	2009-09-17 04:39:55	2003-04-07 12:59:11	14	8	4668	22	1216	2907	2488	163.70	46	86.18	CHANGED	shcp-lsplRT.GRAssulLDslpV-hY...G.s.s....PLsplAslols-sRplhIpPaD.pshlpsIE+AIhs.u....sL.GlsP.p.sDG...phIRlslPsLTEERR+-llKts+.chuEcuK......lulRNlRRDu.cpl.Kchpcpt...loED-h+chpcclQKlTDcalpclDchhppKEKElh	........................................hcccluplRo...G.R.As.s.ulLDtlpV-Y..Y..................G..ssT...........PLsQlAslo..l...s..-uRsLhIs........PaD..+.............o..hltslEKAIhs.S.DL..GlNP....s..s-G..................slIRlslPs.L...TEER.RK-Ls...K.l+.phuEpAK..........VAlRNlRR.DApDpl.KK..hpKct-..IoED-h+c..tp.c.-lQKlTDphlcclDphlssKEpElh...................................	0	421	787	1030
+4319	PF00076	RRM_1	rrm; 	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Eddy SR, Birney E	anon	Published_alignment 	Domain	The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.  The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.06	0.72	-4.34	79	50512	2012-10-02 20:46:34	2003-04-07 12:59:11	17	788	1401	465	29915	55800	1095	67.70	24	23.75	CHANGED	laVssL..s.ssoccpLcphFpp.aGtl.hshplhtc.....ptpscGauFVpFpspcsAppAlpthsu.pplpu+plp	.................................................laVss.L........s..............p.....s.....s........c....p........p..........L......c........p......h....F.........p........p....a...........G..........p.............l.....t...........p..............s..........c................l............h............p...........c...................s.............s........p...........s............+...........G...............a...............u........F.......V...........p.......F........p...........s........t.......p.......s.......A...p..p.......A....l..p..t...h..ss..t.l.tsp.h................................................	0	9087	14852	22632
+4320	PF00398	RrnaAD		Ribosomal RNA adenine dimethylase	Finn RD	anon	Prosite	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.48	0.70	-5.36	20	6621	2012-10-10 17:06:42	2003-04-07 12:59:11	15	22	4983	44	1737	10162	4608	241.80	28	87.89	CHANGED	tsct+pphGQNFLpsppllpcIlcpsslp......pspsVlElGsGpGtlTptL.schs..cpVsulElDs+LschLpccht....psslpl.lppDhhpashPp........................p.atlsuNlPY.sIoosIlcpllp.......ttph..psshlllppphA++hhut.s..hhspLolhhpshs-hphltclspp..................................hFcPsPpVDS...ullclcR+spshh.s.tshppacshlcphhstcspsLtsslpphhstpphpthhc...tlspsshlsthshsphhshaphhsp	.................................................................h....pKphGQ.N.FLh.D...p..l...l..........p...p.I.l.p.sh..s..hp..................ps.s..s..l.lEI..GP...GhGu...L..T.p...L....hc..p.s............pp...lh....u...l.....E....l..D....p.......c.......L.....h.......s..h..L...p...c.pht...................h..s..p.....l...p..l...l..p...t...D....s...L...c...h..s..h...sp.......................................................................................................................tt.h...p..l.l...u...N.L......P......Y....p.....I..o....o..P....l..l.h..+l.lp...............................th......h.p.s...h.hlM...h.Q+..E.V......u..cR..l..s..A...t.P..s...s......+..t.Yup.Lolhh.p.h.h.s............p.s.ph.lh.pVs.p....................................................................sFhPs...P.pV-S..................ull...+..........lh.........+.....t.............p...................................................s.........p.........s.......p.h.h.......................p.....ls...ptsFs..p.RRKs.....l....tss...L.......t.......t.......h.....h.....s.....t.....t...........h.....t.....t.....................................t......lt.....p.......p..t..thh........t.....................................................................................................................................................	0	583	1087	1443
+4321	PF04353	Rsd_AlgQ		Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ	Mifsud W	anon	COG3160	Family	This family includes bacterial transcriptional regulators that are thought to act through an interaction with the conserved region 4 of the sigma(70) subunit of RNA polymerase. The Pseudomonas aeruginosa homologue, AlgQ, positively regulates virulence gene expression and is associated with the mucoid phenotype observed in Pseudomonas aeruginosa isolates from cystic fibrosis patients.	28.00	28.00	29.50	56.20	27.60	27.30	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.85	0.71	-4.51	45	788	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	784	1	95	305	19	150.50	57	94.34	CHANGED	MLpphcpApE+WGGspclID+WLppRQpLlVpYspLsultsh....tsspphss.pplpsFCphLVDYlSuGHFEIY-plhpcscthupp.uhclApplaP+IptoT-ssLsFND+Ysp.tpts..pltslsp-LSpLGEhLEpRF-LEDpLIchLass	....................MLNQL-NLTERVtGSNKLVDRWLcsRKHLLVAYasLVGIKPu....KEuahpLNEKALDcFCQsLV.DYLSAGHFsIYERIl+KlEGsG....pLscAuKIaPpLEsNTQpIMDaaDsslE.sAIDcDNhLEFQQsLSDIGEALEARFsLEDKLIhLl....t...	0	13	31	65
+4322	PF03873	RseA_C		Anti sigma-E protein RseA, C-terminal domain	Finn RD	anon	DOMO:DM07070;	Domain	Sigma-E is important for the induction of proteins  involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and  preventing transcription from heat-shock promoters [1]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal  periplasmic stress.	21.50	21.50	21.80	21.90	20.60	18.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.61	0.72	-4.08	40	851	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	844	4	108	351	9	55.60	58	26.46	CHANGED	sphPVLpTlPhsGsusPVSh.........stst.......ppssspp.QlpcQc+RIsAh..LQ-apLQpRL	................PEoPVFN..TLPhM.G.KASPVSL..........GVPSt....ssssu...pQp..QV.QEQRRRINAM..LQDYELQRRL........	0	10	33	73
+4323	PF03872	RseA_N		Anti sigma-E protein RseA, N-terminal domain	Finn RD	anon	DOMO:DM07070;	Domain	Sigma-E is important for the induction of proteins  involved in heat shock response. RseA binds sigma-E via its N-terminal domain, sequestering sigma-E and  preventing transcription from heat-shock promoters [1]. The C-terminal domain is located in the periplasm, and may interact with other protein that signal  periplasmic stress.	23.20	23.20	23.20	23.20	22.70	23.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.01	0.72	-3.68	35	1145	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1114	6	217	651	141	93.30	42	44.32	CHANGED	Mtc..EpLSALMDGEts-p...pllptLspDp-hppoWpsYHLItDslRu-ss....tshphDluu+VusuL-sEPsh.s.............................ppPtPppsc+ts	...........Mt+..EpLSALMDGEslDs..............-LLs..tL..s..cs.s....E.hpc..TWcsYHLIRDsMRG-ss.........pslchDI.o..uRVhA...Al.EpEPs+ts.........................hhscuQPtPpphpp.............................................................................	0	35	97	162
+4324	PF04246	RseC_MucC		Positive regulator of sigma(E), RseC/MucC	Mifsud W	anon	COG3086	Family	This bacterial family of integral membrane proteins represents a positive regulator of the sigma(E) transcription factor, namely RseC/MucC. The sigma(E) transcription factor is up-regulated by cell envelope protein misfolding, and regulates the expression of genes that are collectively termed ECF (devoted to Extra-Cellular Functions) [1]. In Pseudomonas aeruginosa, de-repression of sigma(E) is associated with the alginate-overproducing phenotype characteristic of chronic respiratory tract colonisation in cystic fibrosis patients. The mechanism by which RseC/MucC positively regulates the sigma(E) transcription factor is unknown. RseC is also thought to have a role in thiamine biosynthesis in Salmonella typhimurium [2]. In addition, this family also includes an N-terminal part of RnfF, a Rhodobacter capsulatus protein, of unknown function, that is essential for nitrogen fixation. This protein also contains an ApbE domain Pfam:PF02424, which is itself involved in thiamine biosynthesis. 	23.20	23.20	23.20	23.40	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.67	0.71	-4.59	118	1246	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	1191	0	247	726	78	133.00	33	87.61	CHANGED	Vlslcss......hshVc.spppou..Cu.uCs.spsuCGtthlsphhss...ps.tphpl.......tsshshcsG-pVplulsEsslLpuuhllYllPLlsllhuuhluphlhts........-hhshlsulhuhshuahhs+hh...scphtp......p.thpPh..llph.h	............................VluhpsG....pAhVp.s.phcuu..Cu..oCu..u+.....suCGothlschssp........ps..pplhl........sssp.sLtsGpcVElGlsEs.oLLp.SAhLVYhhPLluLhlsAsLh.phLhss..........-lhulhuu.llGshsGFlls+th...u+.+.hst......cspaQPllLpl.h............................	0	81	160	208
+4325	PF03113	RSV_NS2		Respiratory synctial virus non-structural protein NS2	Mifsud W	anon	Pfam-B_2717 (release 6.5)	Family	The molecular structure and function of the NS2 protein is not known. However, mutants lacking the NS2 grow at slower rates when compared to the wild-type. Nevertheless, NS2 is not essential for viral replication [1].	21.00	21.00	220.50	220.30	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.72	0.71	-4.17	2	45	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	12	0	0	37	1	123.40	90	100.00	CHANGED	MsTspsc.TsQRLhlsDM+PLSlET.IhSLT+-IITHpFIYLINHECIVRKLsEpQATFTFLVNYEMKLLHKVGSTKYp+YTEYNoKYGTFPMPIFINHsGFLECIGIKPT+pTPlIYKYDLNP	MsTTpssTTsQRLMITDMRPLSlETIITSLT+DIITH+FIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHsGFLECIGIKPTKHTPIIYKYDLNP	0	0	0	0
+4326	PF04479	RTA1		RTA1 like protein	Kerrison ND	anon	DOMO:DM04303;	Family	This family is comprised of fungal proteins with multiple transmembrane regions.  RTA1 (Swiss:P53047) is involved in resistance to 7-aminocholesterol [1], while RTM1 (Swiss:P40113) confers resistance to an an unknown toxic chemical in molasses [2].  These proteins may bind to the toxic substance, and thus prevent toxicity.  They are not thought to be involved in the efflux of xenobiotics [1].	20.60	20.60	21.00	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.42	0.70	-4.87	6	1213	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	150	0	974	1227	0	215.40	25	69.27	CHANGED	IPFlhGsIhEhVGalsRshSSpNsschssallQsVhLLIAPsLYAAoIYMlFu+llclhtscshhLhSu+FsTshFVsuDllShlLQAsGGGLhuss....sS....poTGSpLlhAGLhIQlhhauhFlIsphpFhaplttpshahcc..h............................stpW..hahNhsLhluohLIhlRSIVRlVEFlpGa-GaIIoHEaalYlFDulPMhLssllFlls.hhtNlFchpscs.slp.	................................................hhhG..sh...hEhlGahuRhh.s.....t.....p...s.......s.........s....h...s......s.......a.l.h...Q.h..lhlllA...P.s........h...h.....s.....Aul............YhhLuRll.h..h.....h.....s........s..p.....t.....t............h..l.....p.....sph.hohlFlss.Dl.luhl..lQu....s..G.....G..u.l..h..u..s..u....................ss............hp..h....G...pplh.luG..LslQ.l..hh.h...sh...Fh.hh..s..h.h.........Fh..hR....h..t....p.......t........t...h...t....t.h.t.......................................................................hth.......th...h....hh.s.....L......hh.....us..hh.........I..hl..............Rs.......l.a.R....lsE..........h.......s..........t...........G............h....s.............u.......h.............l......hp............c...............E.hhh.hlhDuhhhhlshhhhsh....h...................hhh..........................................	1	179	455	813
+4327	PF02334	RTP		Replication terminator protein	Mian N, Bateman A	anon	Pfam-B_12997 (release 5.2)	Domain	The bacterial replication terminator protein (RTP) plays a role in  the termination of DNA replication by impeding replication fork movement. Two RTP dimers bind to the two inverted repeat regions at the termination site.	21.00	21.00	21.00	23.20	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.72	0.71	-4.15	3	54	2012-10-04 14:01:12	2003-04-07 12:59:11	11	1	52	17	14	37	0	119.40	66	98.83	CHANGED	MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSEFKpIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQLKVELDRCKKLIEKALSDNF	........................EKRosoGFLlKQRAFLKLYhIT.MTEQERLYGLKLL-lLRpEFKshG..a+PNHoEVYRuLHELl-D.GIL...KQlK.sK.K..EGsKhQEVVLYpF.pD...h..Et..AKLYKKQLKsELDRCttLIcKAlpDNF.............................................	0	1	7	8
+4328	PF02382	RTX		RTX N-terminal domain	Mian N, Bateman A	anon	Pfam-B_833 (release 5.2)	Family	The RTX family of bacterial toxins are a group of cytolysins and cytotoxins. This Pfam family represents the N-terminal domain which is found in association with a glycine-rich repeat domain and  hemolysinCabind Pfam:PF00353.	19.50	19.50	20.70	21.90	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	653	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-13.02	0.70	-6.26	8	309	2009-09-11 00:38:24	2003-04-07 12:59:11	10	16	156	0	5	280	2	490.10	49	61.72	CHANGED	pLsplKsplppshpsststL+pAupssKpuLppAupul+suGKKLILYIPKs..Y-utpGNGLpDLVKAA--LGIEVpR-ERNshAlAppshGTscKlLGLTERGlsLFAPQLDKLLQKppKlusslGSou.slupNLuKApTVLSulQShLGosLuGMcLDELL+spp..Gt..Sph-LAKAGlELsNpLV-NIASussTVDuFoEQlspLGohLpNsKuLGulGsKLpNLP..sLupsGhGLDllSGlLSulSAuhlLuNKcAsTuTKAAAGhELoNQVlGNIsKAVSpYILAQRlAAGLSTTGPsAuLIASsVuLAISPLSFLuIADKFcRAKpLEuYSERFKKLGY-GDuLLApFa+ETGsIDASlTTINTsLuAISuGVuAAuAGSLVGAPIuLLVSuITGlISGIL-hSKQAMFEHVAsKlusKIsEWEKKHG.KNYFENGYDARHtAFLEDsh+lLsshNKEapsERlVuITQQ+WDspIGELAGITRpGDKlpSGKAYVDaFEEGKhLcpcsccFsphlhDPtcGpIDlSso..ppoohLpFlTPLLTPGcEpRERpQoGKYEYITcLhVpGhDsWsVsGVtspsulYDaTNLIQ+s......sssssch+Es+IIucLG-GsDpVFlGSGSoplpAG-GHDsVaYsKsDsGtLTIDuT	............................................................................................................................................pthtphhppus.thKpsh.tuupthppuup+LhLhIPcs..Ycs.pGsulp-LlKAA--LGIcl.hp-tsshthspp.h.sssppllGhT-RGlsl.APQLDpLLQKh.....KluptlGuss.slspplsKstolLSslQshhG.sLuGhsLDpLlpp....t..op.-lAKuul-LhNpLVsslus.spol-uFupQlspLGuhlpsh.tLuulGsKLQNLs..sLs.hu.GL-hlSGlLSuhoAuhhLustsApT.upKsAAGhElsspllGNlsKAlSpYIlA...QR.hA.tG..LSoTu..ssAuLIsSsV.LAISPLuFhshADcFp+ActlcpYucRFKKhsY-GDtLLAtah.+poGsIDAulTsIsTsLuuluuGlu.AAusuSLlGAPluhLVuulTGhISsIL-hSKQAMFEHVApKhts+Is.EWEKp.s...KNYFEpGYDARH...A.L..pDshphL.phs+phtsERslhITQQpWDp.IG-LAuIo+p.u-+..SGKuYlshhcpGthlctp....p...hDs.pG.....IDlSss.....th.o.phlhFhTPhhTPGpE.RERhQoGK.EYhTpL.lpth.DpWplp..tstpushDhopllQhh.......t.ps.ph.ph+l.upLGstsD.Va.uuu.........os.l.uGpGaDhV.Ys+.sphGhLslDup.............	1	1	2	5
+4329	PF00016	RuBisCO_large		Ribulose bisphosphate carboxylase large chain, catalytic domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	The C-terminal domain of RuBisCO large chain is the catalytic domain adopting a TIM barrel fold.	20.50	20.50	20.50	20.50	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-11.91	0.70	-5.58	16	53466	2009-01-15 18:05:59	2003-04-07 12:59:11	15	20	33109	329	419	47715	394	226.70	77	64.51	CHANGED	GItVER-+Ls...KYGRPlLGsTlKPKLGLSuKNYGRAVYEsL+GGLDFhKDDENlNSQPFMRWR-RFLaVhEAlp+ApAETGElKGHYLNVTAsTsEEMacRAEaAKE.lGssIIMhDhlsGGaTAssohApWsRcNs..hlLHlHRAhHuslsR.Q+pHGIpFRVlsKhhRhuGuDHlHsGTV.VGKLEGDtthshGFhchLRpshlppDtucGlFFcQDWuuh.ulhPVASGGIHsh+MPuLlchhG.DDsVLQFGGGTlGHP.GssuGAsANRVALEAhVtARNEGR-hs+E..Gs-llRcAAKhss-LpsAh-lW	................................................GIQVERDKLN...KYGRPLLGCTI.KPKLGLSAKNYG.RA.VYECLR.G........GLDFTKD........D.......ENV...N.SQP.F..MR.WRDRF....L.F.sA.EAlaKuQA.E...TGEI.KGHYLNsTAuT.hEEMhcRA...a.A+E.LG..s..sI.lM.h.D.alsG.GaTA.ssolA.hasRcNs....hL...L..H..l..H.RAhHush....s..R.Q+N.HGh.p.F.R.V.l.s.K.hh.Rh.S.GsDHlHu....GTV.VGK.L.EG-...hshGFh.DhLh-sal.-h.s.hs.p...G.laF..s.Q.D..Ws.....S..h..tV.hPVASGGIHshpM.t.Lh-hhG..DDsVLQ.FGGGTlGHP.G.tsGAsANRVAlEuh......h.u........................................................................................................................................	0	102	241	333
+4330	PF02788	RuBisCO_large_N		Ribulose bisphosphate carboxylase large chain, N-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain of RuBisCO large chain adopts a  ferredoxin-like fold.	20.70	15.00	20.70	15.00	20.60	14.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.59	0.71	-4.44	16	48498	2009-01-15 18:05:59	2003-04-07 12:59:11	11	16	32360	297	249	42335	208	118.10	84	32.42	CHANGED	+hsYasP-YssKDTDlLAsFRlTPQsGVsP.EAAAAVAAESSTG.TWTsVWTDLLTshDhY+u+uYcl-PVPGpssQaaAaIAYPlDLFE....EG..SlsNlhTSIlGNVFGFKAl+ALRLEDhRlPhAYlK	...........................................................................+LTYYTP-Yc.T.K.DTDILAAFRV........TPQ..P..GV..P.PE.EAGAAVAAESST.G.TWT..TV..W..T..D.G.L.T.S........LD.RYKGRC...YcI.....E.........P.....V.......s...............G.........E......E..............s...QY....I.....AY.V....AYP.LDLFE............EG....SVTNMFT.SIVGN.VF.GFKALRALRLEDLRIPsAYsK..........................	0	62	146	202
+4331	PF00101	RuBisCO_small		Ribulose bisphosphate carboxylase, small chain	Sonnhammer ELL	anon	Swissprot	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.15	0.72	-4.16	48	1831	2009-01-15 18:05:59	2003-04-07 12:59:11	15	17	903	230	280	1682	177	80.90	41	69.50	CHANGED	phpThSaLPsLospplt+QlcYllspGWssslEaspspphh..................spYWpMWpLPhFsspDsupVltElppC+psaPstYlRlluFDsh+..pspslSFIlpRPs	......................h..tshSaLPsLo..-.-QItKQ..lpYhlspGWssslEascc..t..h.................................................spYWphathPh..hs.pp.ttlh.plttshtt..st.t.al+h.uhDs................................................	0	88	203	253
+4332	PF02915	Rubrerythrin		Rubrerythrin	Griffiths-Jones SR	anon	Structural domain	Domain	This domain has a ferritin-like fold.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.69	0.71	-3.85	38	3551	2012-10-01 21:25:29	2003-04-07 12:59:11	12	31	1616	63	1303	4084	1248	115.30	23	56.86	CHANGED	-hLttAhsuEpsupthYpthAcphcpcs...lAclFpthAcsEpcHAthlh+hhpch..sh..s.....hhp.pht.hh..............slctshpsshhpEctuY.hYhcltcchtppptpch......hcphspsEptHtchactLh	.................................Lhtu...hsuE.p.p.u.h.p.hY.....t...hh...A...c...t..Ac..c....-..s....tlu...pl.Fp.phAppE.p.pH..Ap..hh..h..c..h....h...p..p...h............................................................................................h.t..................sl..t..t....h..h...t...s...t...h.t.....p...p.....hh......a...h...p....h...u...c...p..........s........t...t...h...t..th................hpthsp..E.ttHtphh.th.h............................................................................	0	520	931	1151
+4333	PF01330	RuvA_N	RuvA; 	RuvA N terminal domain	Bateman A, Finn RD	anon	Sarah Teichmann	Domain	The N terminal domain of RuvA has an OB-fold structure. This domain forms the RuvA tetramer contacts [1].	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.72	0.72	-4.18	33	4290	2012-10-03 20:18:03	2003-04-07 12:59:11	16	6	4259	26	913	2706	793	61.10	36	30.56	CHANGED	MIshl+Gplsclstshlll-ss.GlGYpltsstsphhphspst..psplasphllREDu....htLYG	....................MIuhl+G.h...l....h.ch.....p...s.....s.....h.....ll..l-ss....GVGYclpss........sshh...pl.......ts........t.....csplaTahlV....REDu..hhLYG...............	0	307	609	779
+4334	PF02075	RuvC		Crossover junction endodeoxyribonuclease RuvC	Mian N, Bateman A	anon	IPR002176	Domain	\N	21.50	21.50	21.50	21.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.86	0.71	-4.38	9	3205	2012-10-03 01:22:09	2003-04-07 12:59:11	12	4	3142	4	812	2187	1059	147.50	43	83.83	CHANGED	IlGIDPGochsGYulIcp.suppLphlssGsIRTsos.sLspRLhslh-ulppllcpapPshhAIEplFhupNssSslKLAQARGslhLAAspctlsVtEYsPppVKpAVsGpGpAsKpQVphMVp+lLsLsscPpP..tDAADALAlAIsH	.....................................................ILGIDPG.phsGaGlI..............c.......t......p......G....p.......p.........l.....p...h...lus.....G.s..I....+T........s...s....s..............s..l...s..pRLp......tIasulsclls.p............a.....p.....P.....DhhAI..Ep.l...F....h.s............+......N.....s.s.o...sL.K.LGQARGsAll.A....us.p..ps..L.P......Vh.EY.ssppVKpu..VsGhG.pA-K....pQVp.tMVp.p.....lL.pLs.s..t..P.p..........sDAADALAlAIsH....................................................................................	0	280	550	699
+4335	PF02042	RWP-RK		RWP-RK domain	Bateman A, Schauser L	anon	Pfam-B_9740 (Release 5.1)	Family	This domain is named RWP-RK after a conserved motif at the C terminus of the presumed domain. The domain is found in algal minus dominance proteins as well as plant proteins involved in nitrogen-controlled development [1].	21.90	21.90	21.90	23.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.58	0.72	-4.14	23	430	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	55	0	303	406	6	51.00	45	9.02	CHANGED	pppplohcplppYFphPlpcAA+pLs...........VssTsLK+hCRchGIsRWPaRKl+SL	..................h..tslolpsLpp..YFp.hslc-AA..+.p.LG..............................V.s.sTsLKRl...C...R........phG.I.sRWPpRKlppl.....	0	101	213	273
+4336	PF01365	RYDR_ITPR		RIH domain	Bateman A	anon	Ponting CP (EMBL alignments)	Family	The RIH (RyR and IP3R Homology) domain is an extracellular domain from two types of calcium channels.  This region is found in the ryanodine receptor Swiss:P21817 and the inositol-1,4,5- trisphosphate receptor Swiss:Q14571. This domain may form a binding site for IP3 [1].	20.70	20.70	21.30	21.40	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.31	0.70	-5.10	18	1311	2009-09-11 08:33:13	2003-04-07 12:59:11	16	91	139	8	659	1057	8	191.60	27	11.19	CHANGED	tVhplLp-Lltahsssppctp...p.....c..hh+sh+p+QcLhRp.ulhphVhcllptsascp............hs-ppcttap................clhpLsachLpthppGsRpNQthhtcphs........h.th.hs.G.l.h-slpslLhsN.cLhptlpEtt.lcphluLlc+pG..RcschLDhLpslssusspslcssQ..-hIphpllssGc......DlLlphpl+sshsph	..........................................................................ht.LpcLlhhhhs.ppph.......t...p.........+....sh.+p+Qp.LhRp.shh.p..h.Vhcl..l.p...tsht..tp...........................tpp.pp..t..tap..............................................................................clhp.hsa.chL.p.th...........p...........p.....s.s.RpNQ.t...hht..c..p..ls........................h.....t..hs.G........h...h-......s.........h...ps...llhsN.cLh.p.t.l..p...-t.....t..lc...p....h.Vs....hl...cppG.................Rp.sp.......hL.chLpsl.s.s.s.p..s..p..slcssQ....-hlp.pll.s..s.uc......................-lLlphplhts....h.....................................	0	187	233	423
+4337	PF02026	RyR		RyR domain	Bateman A	anon	[1]	Family	This domain is called RyR for Ryanodine receptor [1]. The domain is found in four copies in the ryanodine receptor. The function of this domain is unknown.	27.40	27.40	28.10	27.70	27.10	27.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.17	0.72	-3.96	38	1192	2009-01-15 18:05:59	2003-04-07 12:59:11	11	75	161	22	593	969	18	92.00	37	8.15	CHANGED	sasPpPlDhoslsLspcLp..................pls-+hAENhH-lWApc+l................ptGWpYG.....scss+pHPpLVPYspLsEpEKchsRphupEslKslluhGaslppsc.c	..............................................................tapPpPlDhop..lt.Ls.c.Lc...........ths-+lAENhHslWAtc+l................ptGWpYG....hp.....Dc.s..s..+pHPhLVPYspLs-......c........EKphsRp.spEslK.sLl.uhGaplphs.p..................	0	108	161	353
+4338	PF00575	S1		S1 RNA binding domain	Bateman A	anon	[1]	Domain	The S1 domain occurs in a wide range of RNA associated proteins.  It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.15	0.72	-3.89	51	46862	2012-10-03 20:18:03	2003-04-07 12:59:11	18	199	5058	118	11675	32137	17037	74.50	26	20.26	CHANGED	phphGsllpGpVpslsp..hGhhV-ls...shcGhl.hSplstp............hh.psspshphGcclclpllcl-pppppl.LSh+	...........................t..phGpll..p.G.p.Vp..p.lss.......hGs.F.V...........-.....l........s................s.........h...........-.......G.l......l........+..l.Scl.s.p........................................................hht.p..s...p.......c...h...l...p........h.G.c.cl....c..VpV...l...c.l....-..t....p..p.c...plsLoh..................................................................	0	3844	7387	9758
+4339	PF00438	S-AdoMet_synt_N	S-AdoMet_synt; 	S-adenosylmethionine synthetase, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	21.30	21.30	22.70	21.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.31	0.72	-3.78	115	5500	2009-01-15 18:05:59	2003-04-07 12:59:11	15	15	4837	44	1389	3870	2374	99.60	55	25.69	CHANGED	ppaLFTSESVoEGHPDKlsDQISDAlLDAhLppD..................Ppu.......RVACEThloTuhVlluGEl............oop...AhlDh...pclsRcsl+-IGYsp....sp.hGFDhcos.sVhsslcpQSs	............t.phLFTSESVoEGHP.DKluDQISDAlLDA.lLppD..................Pp...u..........RVACET.......hVp....TG..hVlVsGEI......................TTs.......AaVD...l...pcllRcTl+-IGYsp........u.c...hGFDuco...C.uVlsuIscQSP..................................	0	486	899	1177
+4340	PF02772	S-AdoMet_synt_M	S-AdoMet_syntD2; 	S-adenosylmethionine synthetase, central domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	21.00	21.00	21.10	22.20	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.56	0.71	-4.17	192	5503	2009-01-15 18:05:59	2003-04-07 12:59:11	11	14	4862	44	1376	3875	2680	120.30	51	30.99	CHANGED	c...p.GAGDQGlMFGYAssETspLMPhPIhlAH+Lsc+LuclR..K..sG.t...l..........saLRPDuKoQVTlcY....s.........s..+..P.....l+.lcol.VlSoQH.sssls.................cpl+cslhcpVIcsll.Pt..t....h.lcs..c.TcaalNPTG+F	....................p.GAGDQGlMFGYAssE.Ts.......pL.......MPhPIsLAH+....LscRlu-lR..K.....sG...p....L.......................saLRPDuKoQVTlcY....-s........................s.+...P..l+lDTV..VlSTQH...s..t.-.l.s.........................pc.p.l.ccslhEcl...I.+sVl....Ps....p..............h..L..cc.....p...T...+aaINPTGRF...............................................	2	473	885	1162
+4341	PF02773	S-AdoMet_synt_C	S-AdoMet_syntD3; 	S-adenosylmethionine synthetase, C-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	25.00	25.00	25.00	25.00	23.80	21.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.85	0.71	-4.44	11	5527	2009-01-15 18:05:59	2003-04-07 12:59:11	11	14	4855	44	1384	3894	2871	137.30	65	35.56	CHANGED	IGGPpGDAGLTGRKIIVDTYGGauuHGGGAFSGKD.oKVDRSAAYAARaVAKSlVAAGLs+RC.VQlSYAIGVAEPLSIhV-TaGTuc..hopccLlcllRcNFDLRPGsIlKpLDLt+P...IYppTAuYGHFGRpc..FPWE+	.................IGG.PtGD.uGLTGRKIIVD..TYG.Gh..u.+HGGGAFSGKDPo.KVDRSAAYAARYVAKNlVA..AG.LAc+CElQl.............uYAI.GVAc...PlSlhV.-TFG.T........u...+........l.s..-.pp..l....h...c.h...V....+...c..hF.DLRPtuII....c...hLDL.......t.+.P.........IYppTAAYGHFGR..p..c.......hs..WEp.......................	0	483	898	1172
+4342	PF02574	S-methyl_trans		Homocysteine S-methyltransferase	Bashton M, Bateman A	anon	COGs	Family	This is a family of related homocysteine S-methyltransferases enzymes: 5-methyltetrahydrofolate--homocysteine S-methyltransferases  also known EC:2.1.1.13, [2]; Betaine--homocysteine S-methyltransferase  (vitamin B12 dependent), EC:2.1.1.5, [3]; and Homocysteine  S-methyltransferase, EC:2.1.1.10, [1].	21.20	21.20	21.20	21.20	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.88	0.70	-5.12	16	4674	2009-09-12 00:27:11	2003-04-07 12:59:11	11	22	3246	24	1463	4033	4093	288.50	31	39.11	CHANGED	llllDGuMGTpLpspshshsc.hhphh..................ss.s..s.ppP-llpplHcsYhcAGA-llpTsTapuo.........hhuhu-hslscts.pplsptusclARtst-phs......psc............hhVsGulGPhsthhs...sschsu.hsssh-..slhchap.phcsLh-uG.sDlLhhETl.shtps+Ahlphlcp.hhpt.uh.shslh.ussl.-uoshppsushhcuhh..h..sphshlGlNCshsspphp.hhphhsp.......sthlhsaPN..uG.s.sss....htastpssphsp......slccaspsGu....plIGGCCGToPcHIptlucslps	.....................................................................llllDGuMG.Th.l.p.....p......h....s...l...s.....t...t..s.h.hht..........................................s.s.-.h..h.s.l.opP-...l..lp..pl.H.p.sY....l........c......AG.A.....D.........l.....l.........p.T.........NT..F..sus.............................hh.s.h..u.c.......a.......s...h...p...p.......h....s...........t-.l....s.tt...usclA.+psscch............................sscp................taVAGslGP.hs...s.....ss.p.s.u.h.t...s..l...oh........-..........plh.pta.p.cphcu.L......l.....-......u.........G.....s.....Dl......l......llE....T...h...Dhhp.s.+A.u....l.....h..ul...c......p...............h...............c.......t.........................s....h................p............hs.......l.........h........s..s....s...l..h.-...u.s..u.....h.p.h.u.u..p..s..h....pu..............h...h...........................p..s.....h..s....l......G..l..NCuh...G...sp...t..h.p.t.h...l...p..t.l.uph...................s..pthl.....s....s....aPN........A..G..L.P..p..ths................pYs..t..........s......s...p...p....hu....p..............hh.p.ca.h.....p..t.Gh..............sll..GGCCGTTPpHI..p..slscslt.s..............................................................	0	500	891	1214
+4343	PF04689	S1FA		DNA binding protein S1FA	Kerrison ND	anon	DOMO:DM04705;	Family	S1FA is a DNA-binding protein found in plants that specifically  recognises the negative promoter element S1F [1].	20.50	20.50	21.10	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.53	0.72	-4.10	4	48	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	20	0	27	40	0	66.70	66	44.78	CHANGED	tsssthEu.KGLNPGLIVLLVlGGhLLsFLVGNalLYsYAQKNLPPRKKKPVSKKKMKREKLKQGVssPGE	.....p....tEs.KGLNPGhIVLLVVuuhLLlFhVGNYsLYhYAQKTLPP+KKKPVSKKKhK+E+LKQGVSAPGE.......	1	6	16	20
+4344	PF05116	S6PP		Sucrose-6F-phosphate phosphohydrolase	Moxon SJ	anon	Pfam-B_6442 (release 7.7)	Family	This family consists of Sucrose-6F-phosphate phosphohydrolase proteins found in plants and cyanobacteria. Sucrose-6(F)-phosphate phosphohydrolase catalyses the final step in the pathway of sucrose biosynthesis [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.42	0.70	-5.08	23	845	2012-10-03 04:19:28	2003-04-07 12:59:11	8	21	568	13	267	12656	492	232.40	21	49.05	CHANGED	sphllVoDLDpThl........u-stuLtchpslhc..thcp-shLlauTGRo.sshpcLhcEhsL.pPDhllsSVGTEIhY..Gp.shhPDpuWpphLsp.cWs+..phVhchhuchPp.L.phQs-p-QpsaKlSaal-ppsu.shlppLpphLccpsLcl+lI.....aSsGpsLDlLPtsAuKGpALpYLtp+aphs...sppoLVCGDSGNDtpLF.lssshGVhVuN.uppE...hl..htEss+sp.plaaAppcsAuGIl-ultHasl	...............................................................................................................................................................................s..hhlh.DhDtThh.......................tp..........t...h.....h..t..h..t....t....h.hp............t...pt...phhhshsTG....pshp.phh....p....h....h.....p........p..h....s.....h..................p.....P......c..h.......h..........l..ss....l..G.......o.c.lhh.....................hp.....p......h.......h..............s.....p.....s.....a......p......p..........h.......l..............s...................p.......t......a....th.............p...tl......p..............c.....h.......l............t....p.................h............s..........p............l.....h................Q......................p...................t.................p...........p.....s.......t.....................a.....................+.......h.......s...................a......h.........h...c....p.....p...t...t........t....p................................l...c.t......l........p...p..h...h......p..t...p...s....l....p...s...p...h.h.................................h.....p...s......u.....h.....c.....l...D..ll.....P.h.sA.u.Ksp.A.l.p.a.L.h...p.+..a...sls.............hpp...h...l..s..h...GDS....G....N.D...h.p...hL..t.....sh.......t....pu..h.ll..uN...spt-....................................................................................................................................................................................................................	0	83	184	233
+4345	PF01023	S_100	S_100_domain; 	S-100/ICaBP type calcium binding domain	Finn RD, Bateman A	anon	Pfam-B_242 (release 3.0)	Domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	20.30	20.30	20.30	21.00	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.88	0.72	-4.63	24	1006	2012-10-02 16:17:27	2003-04-07 12:59:11	14	21	63	279	499	923	2	43.00	37	14.75	CHANGED	LEculpslIslFHpYSs+cGctpsLsKpELKpLlp+ELssaLcp	........LEpultslIssFHcY.usc-..G..c.p..tp.LoKpELKpL.lppELsshlp........	0	28	46	114
+4346	PF05124	S_layer_C		S-layer like family, C-terminal region 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	22.50	22.50	22.60	22.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.51	0.70	-4.72	21	129	2009-01-15 18:05:59	2003-04-07 12:59:11	7	18	45	0	79	134	6	166.90	23	29.97	CHANGED	psluussGaAplhIssslKsl-LG-EalsDaEhhsllpss.......sslchp-s..................hts...pplGlALpYsGDclpslccscphc.lusYA.ph.hDD-sp.s.cLpsaFphc....EpK-lolshGpclp...Vhsu-lhhp...tts..sh.hssPlshLDoEh...uL-su-psLILVGGPVVNplTcELsss..GtlsI..........-spSsATlsllcssAN..GscVLVVAGGDRtuTcpAApALlphl	........................................................................................................................................................................................................................................................................................................................................................................................................................s..ph.................s...p.hs..pslILlGGPVuNtlscp.ltsp....h.lpl.............................................s.sps.u...s.lt..h......l.......c.......sshN......sps.VlllAGu.DR.uTcsAsphh..........................	0	8	16	59
+4347	PF05123	S_layer_N		S-layer like family, N-terminal region 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	\N	25.00	25.00	30.00	28.90	24.70	22.20	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.82	0.70	-4.78	18	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	36	0	27	57	1	268.00	29	44.88	CHANGED	KKIGAIAVGuAMluouLuouuh.AspclG-VssFh...sshVK.sGpPNVcIVVGSsA.AAhDVVSAAsIAAKIGSLhYpEssVE..DuSAslshsssu-S--lsl....h...sth.hhussspthlhsuuDsDY..........s.shsssshsshshsuhspsc....ssssLtD...........................LssLhplpDlDPssa...............hs.sDhD.AsEhlhsplsss.......h.ssotshplscDpllYsols..................apsshsuh..tshpsLp.....GhcIPaLGcEhslVclDpD.........DDhlhlGpcsY-Gslcp.G-saslGsGYpVcl	..............................KKIuAlAlGuAMluusLusush.Ahpp.l.uslss.....s.hVp.sGpPNVcIVVGSsA.AAhDVVSAAsIAAKIGSLhYpEtslc..ssusslphpspsc.o-sh.l.....................hss.sstthh.hs..ssss.sY.................s.t...s...ss..hs.....sh..htshsphs.....thhslt-..............................................................................................................ls...shhplpch..DPpsa...............hs.pD.-...us...Ehlhshlpss.................stphpltccphhYholh.....................hpss...ts.....t.htslt..............Gh..plshLGpchhllplsts.........schlhlGp.sapGhlcp.G-shslGsGYplcl...................................................................................................................................................................................................................................................................................................	0	3	6	16
+4348	PF00954	S_locus_glycop		S-locus glycoprotein family	Finn RD, Bateman A, Mistry J, Guo X	anon	Pfam-B_357 (release 3.0)	Family	In Brassicaceae, self-incompatible plants have a self/non-self  recognition system.  This is sporophytically controlled by  multiple alleles at a single locus (S). S-locus glycoproteins, as well as S-receptor kinases, are in linkage with the S-alleles [1].	21.80	21.80	21.90	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.31	0.72	-10.95	0.72	-3.78	52	2074	2009-09-12 20:30:07	2003-04-07 12:59:11	15	105	84	0	900	2114	0	104.00	27	16.50	CHANGED	aRSGPWN..GhRFoGlP..-hp.thsh..hshsFs.....psspElsaoaphs.sssh.hSRlhlossGhlpphsW.ssspsWsh.hattPtc.pCDhYthCGsauhC...sssssPh..CsClpGFhPcs	...........................................................................s.Wt..t..h...........................................h.....h.shs..........pspp.Ehh.as..a..p.h.t.....s...s......s..h......h.s.R.l..sl...s.....s........G....p...l.p.hhs...W..........t.....s...s...p.......p...W.s........h.....h...a...p.....t...P..p.......c...pCD.h......Y......s......hC.Gs.a..u..hC.............s..h..s....s.........s....P.h.....Cs..Cl.p.GFpP.........................	0	43	507	728
+4349	PF00526	Dicty_CTDC	S_mold_repeat; 	Dictyostelium (slime mold) repeat	Finn RD	anon	Pfam-B_96 (release 1.0)	Repeat	\N	21.30	21.30	21.80	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.84	0.72	-7.18	0.72	-4.07	30	447	2009-01-15 18:05:59	2003-04-07 12:59:11	13	20	8	0	381	438	10	23.70	56	31.53	CHANGED	NsCThDoCsspsG..CsHTPlsCDDs	.NsCThDSCsss..s.G..CsHTPIs.CDDt......	0	300	381	381
+4350	PF00277	SAA	SAA_proteins; 	Serum amyloid A protein	Finn RD	anon	Prosite	Family	\N	21.10	21.10	21.20	21.30	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.41	0.72	-3.67	18	208	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	68	0	67	243	0	98.00	63	73.11	CHANGED	WapFhtEAsQGAtDMWRAYpDMREANa+sSDKYFHARGNYDAApRGPGGsWAA+VIScuREshQuhh.........GRGtEDotADQcANcWGRSGtDPN+........YRPpGLPcKY	.......................hpFltEAhpGAtDMWRAYs.DMREANYpsuDKYFH.ARGNYDAApRGP...G.Gs....W....A...AcVI........SDAREshQphh......................G+GtEDShADQtANcWGRS.GpDP.N+...............aRPtGLPpKY.....................	0	12	14	23
+4351	PF04455	Saccharop_dh_N		LOR/SDH bifunctional enzyme conserved region 	Waterfield DI, Finn RD	anon	COG1915	Family	Lysine-oxoglutarate reductase/Saccharopine dehydrogenase (LOR/SDH) is a bifunctional enzyme.  This conserved region is commonly found immediately  N-terminal to Saccharop_dh (Pfam:PF03435) in eukaryotes [1,2].	22.10	22.10	22.10	24.60	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.10	0.72	-3.90	35	168	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	154	4	103	180	22	102.10	34	17.28	CHANGED	hhs.Rp..lELcGHllDShlls+slDpIh-hGGsFcllcFslG+p+sDsSaAclpVpAcspcpL-pILspLpplGAs..s-....p-scLtsuspDtVhP-sFY..oTTNas	...................................h..scplcLcGHLlDohlls+sLDhIh.-hGGsFcl.lchc......l......G.pp.....+.p........ssS.aAclp.VsAsspphL-cIlspLpslGAs....-........p-spht...ss.tstVhPcsFYsoT.h..................................	0	34	78	97
+4352	PF04092	SAG		SRS domain	Bateman A	anon	Pfam-B_1675 (release 7.3)	Family	Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of Toxoplasma is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. SAG1 is composed of two disulphide linked SRS domains. These have 6 cysteines that form 1-6,2-5 and 3-4 pairings. The structure of the immunodominant SAG1 antigen reveals a homodimeric configuration [2]. The SRS domain is found in a single copy in the SAG2 proteins. This family of surface antigens are found in other apicomplexans.	20.80	20.80	20.80	20.80	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.94	0.71	-3.74	58	921	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	7	14	768	924	0	131.00	20	67.81	CHANGED	sssssoC..............sssssssplslopp.ssolTlpCussss....hhPs..shsp......................ptCs....t.ttssp.hslpslL..ssssps..Whpt......spsspstsL.slspsshPtss.psFhlGCptpsss.....................sttssCpVpVsV	..........................s...hssC......................ts.ss..sshpl.slopp.psslolpCsssss.......hhPs..shsp.........................phCp...............t.t...ss...s..p.t..h.sl.s..s...l.l.....ssssps......hhpp..................sssssshsL...sls.sshP.t.ps..p..p..h..hhu....Cttssss......................................................................tttssCpVpVsV........................	0	325	325	768
+4353	PF01259	SAICAR_synt		SAICAR synthetase	Finn RD, Bateman A	anon	Pfam-B_1426 (release 3.0)	Family	Also known as Phosphoribosylaminoimidazole-succinocarboxamide  synthase.	19.70	19.70	20.70	21.10	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.54	0.70	-5.28	11	4852	2009-01-15 18:05:59	2003-04-07 12:59:11	13	18	4550	22	1252	3379	2876	240.90	34	87.99	CHANGED	ph.llsc.....GKs+-IYcl-D..spLLhlspDclSAaDslhcspIstKGplhsphSpFhFphLp.h.lssHhlct.s......................-.sshls+KhchlPlEsVVRsYlTG....ShhKc...sGsh..cGlclsssllEs.hhs-slhsPphpsE...Hs.slu........hsps..hlG.-pssplcchshplaphhcchhtppGlIlsDhKhEFGlDp-s.cllLsDEl..PDSSRhWsssshc....h......hDKQhhRchLsssspuhp.ts....hsphspsl	..........................................................p.thlYc...GKsKclY..........p...........s..............s.........c............shl.l.hh.hpDcho.........A........as...s.h......hp.......p.......p.....l....s.sKGtlsNplosahFctLp.....c.........h....sl........s.....o...Hhlcths.........................................................s...pphl.l..+...+...l......c............h...............l..P..lEsVlR.shh.s.G....ShhK+....h..G.hc........pG....h..tLs.p.slhEh......hh.K.....s..........D.........sltDPhhssp..........Hspsls.........................................hss..t....................................-.p...l.s...pl...+...chs......h......cl....p....hlpchh..t.ptG.....lhLlDhKlEFG....h..........s......p.....s..G.......c......l.lLuDElu.PDosRh..WDtcshc......p..............hD.K-haRp.....Ls.s.h..h.tsap..thh.+l....hh.....................................................	1	399	785	1040
+4354	PF03534	SpvB	Sal_SpvB; 	Salmonella virulence plasmid 65kDa B protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.00	20.00	20.20	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.82	0.70	-5.39	17	349	2009-01-15 18:05:59	2003-04-07 12:59:11	8	62	230	0	113	340	33	223.30	27	12.78	CHANGED	LussGssGhAolSlPLPlSsGRG...huPsLuLsYsSuuGNGsFGlGWphslhsIsR+Ts+GlPpYssp.....DpalGPsGEVLlssh.sspGp.phcpt.pthtshshstsaoVoRYpsRlEupFsRlEaWpPpsssss............sFWllassDGplHlhG+sspARlusPp....ss.s+lApWLLEESVo.ssGEHIhYpYcsEDcsss-tschpsp............stoAQRYLppVpYGNhpsutsLashss....s.Pssp..p.........WLFpLVFDYGERssshpssPtaps..........stsWhsRpDsFScacYGFElRTRRLCRQVLMFHph	...................................s.s.GtA.o.holPlslssG.R.u...hsPsLuLsYsSs....u.........G.......N....G......................hGlGWsl.u.s.....u.I.p......R..........c....T.p.......t........s..lP.p...Yssp........-t.h...h.h.suc.hl........stt.st..................tp..................................................tth..t.s.....t..pa.sc.hp.s.t..Ft+lphht..sts..sstt.............aWhlhstsG.hthhG...t.....s......s....su.+.l.....ssst......................t.....tphhpWhl.p.cshs...stGpt.lhYpYttp...s.t.....................................................................................................................................................................................................................................................................................................................................	1	46	73	97
+4355	PF03538	VRP1	Sal_vir_VRP1; 	Salmonella virulence plasmid 28.1kDa A protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.80	21.80	21.80	22.50	21.20	21.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.12	0.70	-5.38	4	244	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	119	0	42	182	1	201.10	21	19.16	CHANGED	sppsSPLL........S+ltstaplsstlhcp..............GYpSlFDIlRhsRcpFIccapt..us+utt.haDhAsuhApQlhppFRpppL................o+tV+tshhpsaSs.s.......PpYts.F.-s...WpphsPssusEussSPVuYLhclYphs.p.E.susspul.slsERRsDLusLhlsscuINppIssLplVNphLSpthpthlp.ps.t..ss.thLupsRaP.pLPYcasppQIphuhsspcspLtcIhppsshsaP...W.......................................................................h.....LSsslssA.schsh...........................................................................................hAsphu.pQQplhsEsltssspp...FYQsNYGlss.sss.hctlshFspQTuloVs	...........................................................h..............................................................................................................................................................................................................................................................ushtYh..hh.......................................t.................h..thspRRPDLtpLhlsp..pshppplssL.h..phh..........................................................................s.h..hPYp.shp.lp....l...s..thtth...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	6	18	32
+4356	PF01758	SBF		Sodium Bile acid symporter family	Bashton M, Bateman A	anon	Pfam-B_697 (release 4.2)	Family	This family consists of Na+/bile acid co-transporters. These transmembrane proteins function in the liver in the uptake of bile acids from portal blood plasma a process mediated by the co-transport of Na+ [2]. Also in the family is ARC3 from S. cerevisiae Swiss:Q06598 this is a putative transmembrane protein involved in resistance to arsenic compounds [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.22	0.71	-4.89	17	4441	2012-10-02 17:06:44	2003-04-07 12:59:11	11	12	2582	2	1463	5194	1717	184.60	24	56.02	CHANGED	slhLhlhMashhhplphcchtphhpc...sKhlhluLlhpallhPllhFllu.hhhthhst...................hhhGllllGssPssuhu.las.LucGchs.Lulshsshoo....htshhhsshhhhhlstt.h.ls........h.hhphhtolllhlhlPhhhGhls+hhh.......hh.phhh.hlsshulhullhslhlhhuhpuphlsph	..........................................................................................hLhlhMa.shhhp.lphpch.t.pl.h.cc.................s+...s.............l...h...l.u.l.l.h.pa...ll.hP.hh....h.a.h.L...u....h...h...h...t..h...st..............................................hhsG.l.I.L....l.G.s.sP.s.s.s.h.s.....V.a..........o.hL.uc..GDss..h...................ols.h.sul...so........lhshhhsP......lh...h....h....h...l...s...s.t...h..ls...........................h..h..s..h...hh..S.l..lhh.lll..P..lhhGhlh+.thh...............................h.h..t...p..p..h...h.s..h..l...ss..ho.l...l...ul.lhs.ls.lh.hu.hpsp.lh..t....................................................................................	0	485	921	1207
+4357	PF03536	VRP3	Sal_vir_VRP3; 	Salmonella virulence-associated 28kDa protein	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	40.50	33.00	19.10	21.30	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.68	0.70	-5.21	3	62	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	47	13	7	51	0	213.90	60	91.85	CHANGED	PINRPsLKLNLPSLNVVssSEtPQMsSTNE+LKNNFNSLHNQMRQMPsSHFKEALDVPDYSGMRQSGFFAMSQGFQLsNHGGDVFIHA+RENPQSKGDFAGDKFHISVtREQVPQAFQALSGLLFSEDSPIDKWKVTDMERVsQQSRVulGAQFTLYVKPDQENSQYSAShLHKTRQFIECLESRLSESGlhPGQYPESDVHPENWKYVSYRNELRSGRDGGEMQcQALREEPFYRLMsE	............................................................................................s.h..sssc..cLKsNFs.L.asQhRphPsoaFK.A.sVPsYSshpQSuFhsMtQG..FQ.lsNH....u.hDVFIHAcREsPQSpGcFAGDKFHISVhR-.VPpAFQALSGLLFSEDSPVDKWKVTDM.....p+Vs.....QQuRVulGAQFTLYlKPDQEsSQYSApaLHKhRQFIpCLEScLScsGVh.sG.ppP-SDV+PEsWKYlSYRNELRS......sRDGuEhQcQtLREEPFYRLMhE...............	0	2	3	5
+4358	PF01536	SAM_decarbox		Adenosylmethionine decarboxylase	Bashton M, Bateman A	anon	Pfam-B_600 (release 4.0)	Family	This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes.  In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine [1]. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.	21.20	21.20	21.30	21.40	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.20	0.70	-5.77	15	693	2009-01-15 18:05:59	2003-04-07 12:59:11	11	8	387	56	340	679	15	293.80	34	87.33	CHANGED	sSAhuFEGhEKRLEI.Fhcsthhs-spu+GLRuLs+uplDclLssAcCoIVSohuN-plDSYVLSESSLFVasaKIIlKTCGTT+LLhuIPsILcLAcslu...........hpVpuVpYoRtsFlFPssQsaPHRsFoEEVshLDuaFu....supAYlhGsscps.p+WalYoso.....sps.....pps...pPsaTLEMsMoGLD+-pASlFaKscu...............usAusMTppSGIc+ILPsSpIs........DFpF-PCGYSMNu..l-usshuTIHlTPEDGFSYASFEosh....hshcshslspllp+VLsCFcPscFSVsla....sssss+phpp.shsl-lc.uYshcctshpsls.hussllYtcFs+st	..............................................................s...hFEG.EKhLEl.F.................................................................t........t.......s.......t........s...........LR.s.ls....ttphcphLp.spCpIlS.hp.......s.......ct.......hDuYlL..S..ESShFVash..+.lllKTCGTTpLLhuls.l.....Lc.lAtths..........................................hp.ltplhYoRts.FhhPt.....t.Q..h.PH.csap-EVthLsthFs.............supAYhhG.p..sps....pW...alYsss....................................t................p........................ps.s.TLE.hhMo.tLD.p...hsp..F.ah.s.ps.....................................................................sputthoptoGlp..c..lh...Pt.s....t....l....s................................................sa.FpPCGYShN............u........h.................p......ss......th.TIHlTP..E...s....t....a..SYASFEss...............................p.t.h.s.h.sp.llp+VlthFp..PscFslsla.............t.t.t.t..........t................h...........................................................t...............................................................................................	1	100	180	271
+4359	PF02199	SapA	SAPA; 	Saposin A-type domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.30	20.30	20.50	20.40	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.07	0.72	-4.19	32	428	2009-01-15 18:05:59	2003-04-07 12:59:11	10	66	91	0	167	403	0	33.70	48	10.43	CHANGED	GpcpCshGPuaWCpshcsAppCs..AVpHCpppVWs	.......GhcpCshGPuaWCpshcTAspCs..AVcHCpppVWs......	0	47	59	101
+4360	PF03058	Sar8_2		Sar8.2 family	Mifsud W	anon	Pfam-B_2148 (release 6.4)	Family	Members of this family are found in Solanaceae plants, a taxonomic group (family) that includes pepper and tobacco plant species.  Synthesis of these proteins is induced by tobacco mosaic virus (TMV) and salicylic acid [1]; indeed they are thought to be involved in the development of systemic acquired resistance (SAR) after an initial hypersensitive response to microbial infection [1,2]. SAR is characterised by long-lasting resistance to infection by a wide range of pathogens, extending to plant tissues distant from the initial infection site [2].	27.10	27.10	27.20	27.90	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.40	0.72	-3.66	4	33	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	9	0	0	33	0	83.60	47	99.24	CHANGED	MFSKT.LFLChSLAILlhVISSQADAREM.SKAAAPITQAMNSNNIoD.QKoGAGllRtl.Ghhh+hspsh...................CKhCpCp.tlCshC..Ct	..Mh.KsNlF.LChSL.IlLhlISSQssAREM.ScAuA.slTpuMsuNNhTp.pKsG...uulh+plsshhppssp.ssp.....................hhGpsCKhCssph..C.h..........	0	0	0	0
+4361	PF04790	Sarcoglycan_1	sarcoglycan; 	Sarcoglycan complex subunit protein	Waterfield DI, Finn RD	anon	Pfam-B_6135 (release 7.5)	Family	The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle.\	  The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains.  This family contains beta, gamma and delta members [1,2].	27.40	27.40	27.80	29.50	26.80	27.30	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.62	0.70	-5.22	16	335	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	85	0	193	287	0	224.50	34	82.30	CHANGED	laplGIaGWRK+ClYhhVLLLhllhVlNLsLTlWIlpVhpFs.cGMGsLclppc.Glpl.cGco-F..lpPlYspcIcuRpDpsLhlpS......spslolNs...RNtpGpls..s+lslusct..l.stsptFplpss.st+.LFosDpsphhht.tpLclssPpGu....lFt+uVpTstl+us.sspcL+LESsTRplshcAscGVplcAtAGtl-hpuppDlpLpSs.......cGplhL-A.pslhLs....+LPhups......ssGspps...hYclCVC.ssG+LFhussstsps....Cp	.............a.hGlhGh+ppshahhllLLhllhllNLhlTlh............IhtV.....hphs...sGhsphcl...ppp...G..........lhh...c.G.o-h......l..PL.atpplp...uR.spsLhlpS.......spslslpt...hs..Gph.........spL..ls.pt..s.spsptFplpss..stphLFosDtpph........h..phspGs..................lh.pslpTstlp....up..s.p-LplcSssR.lhhcuscGVplputs..lchpst........t-lpLp.S..............-GplhLsu...tslhls....pLPpus....................sst.tpt................haclCsC..ssGpLahs.ssstp.................................................................................................	0	42	56	118
+4362	PF03343	SART-1		SART-1 family	Mifsud W, Mistry J, Wood V	anon	Pfam-B_3690 (release 6.5)	Family	SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing [1][2].  It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae [3].  SART-1 is a known tumour antigen in a range of cancers recognised by T cells [1].	20.50	20.50	20.70	20.50	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	613	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.63	0.70	-13.46	0.70	-6.17	38	393	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	272	3	287	395	7	455.60	25	80.12	CHANGED	-uLSIEETNKlRhpLGLKPLslsss............................ssshcscputshcshpch........pcpscs++cc-ch..pppIpc...u+-ctp.pppKLts..psLu-t...........t-ss.DspuWlpcp+Kh..p+phpttctct.....................tpptpc+pps..spasspD...LsGlKVsHclcchpc..GcshlLTLKD.ssVL-s--t.....D.LpNlsLh-+c+tpcplch+K+p............p.sp...t.tppslLu.pYDE-lpsccpcp.........hph......cspupssct..................................pppccp......pspt+h+hphhsh-.....................spspp.sSDYhs.p-.lK..hKKsKK....................Kctpppp++phh......Dp.t..st..t..s.t.tttt...............cl-pps......................ss.hcpc.p.ps.shs...............DD-DL..QtpLsppR+hth+....c+pchcs.EclAcplcpppspsp........pcpp-.......................csulVls-TSEFlps..Lp........psshtcpttpp...................pcpspp.tsh.psppsptp.............tstssphpps.ss.pcc-........................t..tthssshl-cEsslspGLuusLphLKp+Gllc................ppppchhtppthhth..phptphpcct.c.tss+hsph....R-chh.chppcp+-ppc..............................tY+PcVcLcYlDEhGRphssKEAFKp.LSHpFHGKGsGKtKpEK+lKKlE-E+	.................................................................hSlE-sN+lRhpLGLpPl.h...........................................................t..t..t.p.h............................t.....pptpth...tttltt....+ptt..........htt..ttltc.....................sh..sWl.p.pph.....................................................ttt....ttts.........LtslpVtHthtph.p....ttp.lLTL+D....psl........pptp....................D..L.N.p......hhcppchpcpht.pppt......................t..........................t.....t.l.Lt...pYD-....p.ttpt.pt..............................tttt.h.....t..........................................................................................t.tt..t........t.tp.p..t..p.p.........................t.t.ss-h..hp...tc..h.p.....hKK.K..p.....................................+h...th.pp...................................................................................................t....................................................................................t..............................................--..t-h.....tt.Lttt+pht.h...........t........p...p.....tlh..p.lt.t.ttt.............................................................................tsslhhsthsEFsts.....lt...............t......t.....t...............................................tt..t....t.t.tt.............................t.thtt....p...tt.............................................................................................................h.ttE..hstGhuusLthhpp+uh.lp..........................................................ttt......t..ptp..h.........t.......t....p.pcppt....................................................................hpsplplpYhD-.G+.hs.KEAF+..LSHpFHGKssGK.K..hEK+h.K+hppc........................................................	0	101	164	247
+4363	PF00269	SASP		Small, acid-soluble spore proteins, alpha/beta type	Finn RD	anon	Prosite	Family	\N	20.60	20.60	20.70	20.70	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.84	0.72	-4.11	66	1862	2009-01-15 18:05:59	2003-04-07 12:59:11	15	3	421	3	380	1047	9	56.40	40	83.13	CHANGED	NchlVPp..AcpAL-ph................KhElApElG....V..thppt..G..-lTSRpsG.p....VGGpMVK+MlpttEppht	.....................................Nphhl.tAppul-ph....................KaElApEhG...........................V.p..s..s.....t.....sh.o..uRpsG.u........VGGph....sK...RhlphAEppl.t.......................	1	177	310	333
+4364	PF04259	SASP_gamma		Small, acid-soluble spore protein, gamma-type 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The SASP family is a family of small, glutamine and asparagine-rich  peptides that store amino acids in the spores of Bacillus subtilis  and related bacteria. 	25.00	25.00	26.00	25.80	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.66	0.72	-3.85	7	317	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	241	0	29	139	0	75.60	64	86.98	CHANGED	StTsAQpV+pQNtpSut............t.auTEFASETNsQpV+QQNtQSt.t.t.su.......utpspassEFASETssppV+pQNtpupApKppsS	..............K.ATSGASIQSTNAS...........YGTEFA.TETNVQAVKQANAQSEAKKAQASuA......QSANASYGTEFATETDVHuVKKQNApSAAKpSQSS...........	0	8	20	22
+4365	PF03898	TNV_CP	Satellite_CP; 	Satellite tobacco necrosis virus coat protein	Finn RD	anon	DOMO:DM04608;	Family	\N	27.20	27.20	28.60	306.80	21.10	27.10	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.30	0.71	-5.26	4	4	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	4	62	0	5	0	199.80	42	98.28	CHANGED	MoK+Qsppps....+psstpsV+sIlpsphEpKRFsLlsssNsssTAGTVhNLSNsIIQGDDIsQRoGDpI+hhpphL+sRsTuITsSQo..F.RFIWF+DNpNRGTTPuVTEVLsSAshhSQYNPlThQQ+RFTlLpD.VpLsCSlsGcsIKcpshshstp.tlaYNGAsuVAuSNGPGAlFhL.IGDplsG..paDluhEhhYhDh	MoK+Qsppps....+psstpsV+sIlpsphEpKRFsLlsssNsssTAGTVhNLSNsIIQGDDIsQRoGDpI+hhpphL+sRsTuITsSQo..F.RFIWF+DNpNRGTTPuVTEVLsSAshhSQYNPlThQQ+RFTlLpD.VpLsCSlsGcsIKcpshshstp.tlaYNGAsuVAuSNGPGAlFhL.IGDplsG..paDluhEhhYhDh	0	0	0	0
+4366	PF03110	SBP		SBP domain	Bateman A	anon	Pfam-B_737 (release 6.5)	Domain	SBP domains (for SQUAMOSA-pROMOTER BINDING PROTEIN) are found in plant proteins.  It is a sequence specific DNA-binding domain [1]. Members of family probably function as transcription factors involved in the control of early flower development [1]. The domain contains 10 conserved cysteine and histidine residues that probably are zinc ligands.	21.60	21.60	22.20	22.70	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.08	0.72	-3.76	30	552	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	54	3	340	562	0	72.80	55	16.94	CHANGED	pCQVEuCsuDLSsu.KpYHRRHKVCEhHoKushVl.luGlpQRFCQQCSRFH.LsEFDEuKRSCRRRLAGHNcRRRKsps-	.................................CQV-GC.psDL.oss.K.cYHRRHK....VCEhHu..K..ust.V...l.luGh....p..p..RF.......CQQCS.............RFH.LsEFD.p......s......KRSCR+RLss.HNc....RRRKst..t.....................	1	93	251	302
+4367	PF00496	SBP_bac_5		Bacterial extracellular solute-binding proteins, family 5 Middle	Finn RD, Yeats C	anon	PDBSum	Domain	The borders of this family are based on the PDBSum definitions of the domain edges for Swiss:P06202.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.29	0.70	-5.64	226	27055	2012-10-03 15:33:52	2003-04-07 12:59:11	17	39	4221	130	5660	20528	6027	361.60	19	67.34	CHANGED	plhPtLAcs....................p...hssDspsasFpLRcsl+apDG.s......slTAcDVha....o.....hcchhssssssthhhhh.................................................htplpsscshslplphppP.ss.........hhhhhsthstthh.....................................................................tttttsthtppslG..oGPaplpp...ap....sp...plh.lp+.......Nss..Y...W.......................t.sps....tlcplphphl......csssthtth.psGclphh..hths.....ssshtth....ttptthph........................tts...shthhhlthNhp.....................pt...sh.sc..........hplRpAlshAlD+c.tlscth...................h.tshstsstsh.hssshshhtt.ht.......................................................hs....pcA+pLLpcAGhpss.......................................hhhhhsssssstp.phuphlppplpp..lG.......lclplpsh.t.........................................thh........psshshhhh..sasss.hssstshht.hhtssstst	..................................................................................................................................................................................................h.PtlAcp.h.................................................................p...h.s..p.D..s......p...s...a...s...Fp..L..R....c..s.s.....+....a....p...s.....G..p...................................sloA.cD....l..ha........o.................h..p...+...h..h..s....p.s.ss..thhhhh.........................................................................................................................................................hhs.lc...s.h..D...s..t.T.l...p.lpLppP...s...................h..hhth..l..u........s.h.hhh.....................................................................................................................tt.t.t...t...t..t..p..h.s.p...p.s...l.G..........oG.P.a.p.lpp....................apt...sp......plt..hp.+................N.ss........Y.....W.....................................................t..tps................t.lc.p.lph.phh.................-s....ss...thtt...h...ps..Gp....h...p....hh.......t.h..s..............sp.p..h..t.p.h.............pp.s.tthph...............................................................ts....sh.shh....h..l..th.Nhp....................................................ps....sh...ss............hplR.pAls..h..ul..c..+.........p...tl......s.p.t.l....................................................h....t..s.....t....s...p.....s......s....t......sh......hs....s....s...h..h..t..h..s..s.t.ht...............................................................................hs......pcA....+....p....l.....L....p....c....A....G..hp....s.......................................................................................hhh.h.h......t.....s.....p.....s.....s.....t....p....p....hu.......ph.........lp...p.p....hpp.....lG...........l.p.l.p.l...psh...ph..................................................tthhpt....hp.p.t..p.a..c..h..hhh.....s.a...s..ss.......ss..thh..h.t......t.............................................................................................................................................................................................................	0	1562	3337	4515
+4368	PF03480	SBP_bac_7		Bacterial extracellular solute-binding protein, family 7	Bateman A	anon	Pfam-B_808 (release 7.0)	Family	This family of proteins is involved in binding extracellular solutes for transport across the bacterial cytoplasmic membrane. This family includes Swiss:P37735, a C4-dicarboxylate-binding protein [1] and the sialic acid-binding protein SiaP. The structure of the SiaP receptor has revealed an overall topology similar to ATP binding cassette ESR (extracytoplasmic solute receptors) proteins [2].  Upon binding of sialic acid, SiaP undergoes domain closure about a hinge region and kinking of an alpha-helix hinge component [2].	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.60	0.70	-5.30	35	6254	2012-10-03 15:33:52	2003-04-07 12:59:11	8	19	1778	54	1762	5551	7504	278.70	22	82.64	CHANGED	hupss.ussssptpus.phFschlpEc.osGcl..plplaP..supLus-t.phlctlpsGs......l-hshsusuhhssh.sPphtl..hsLPFlF.........pstptsc+.hhsuthu..cpLhpphcpp.GlpsL..ua.apNGh+phos.sp+PlpsP-Dh+G..LKlRl.tushhhphhctlGAsPpshsauElYpuLpsGslDGpENshssl.hst+haEVQKYhohos..Hsh...sshhllhspshassLst-hpphlccAspEus.phtpchhpctspphhppltc.....sGhplh.hos.cppsa.pcuhpslac...c.atcp	.............................................................................stsp.s.h.t.t.sh..pth.u.ch...l..p...c..t....osG.c.l..plc.l.as....supL..s.s..st...ph..h-..t..l..ps..Gs......l-.hs.h.s.s.s.s.h.h.s.sh..sP..t.hsl.......h..s..l..P.....a.l..h..........p.s..h...p.p.h..tp...h..h...s..u..t..hs...........ppl..h..p...p..h...pp....p....G...h..h.s..L.....uh...h..........s...s...G.h....c...p....h.....ts....t....p....+.....s.....l...p........s..s...s.....D.....l...+...G.....lK...l.R.s.......s....s.....h.h.hp..h....h.c.t.h....G.....A.....s.....P..ss.h..s.h.u.E.lYsALp.p.GslD.u.tE..s.s.h.s.sh..hshp.a..h.E..V..t..+..a.h.s.h..s.s.......ash......s.s..h.h.ll..hs..pp...h...a.ss...L..........s...s..........-............pphlpp.u..s....p.cus....p...h....t....p........p..h....h.............p....p....t.........p.p.....p..t................hp.......p.hpp.........tG.s..pl........h..s..p......p.h.p.sa....pc..s.s.p.s.h.hpp.....t.........................................................................	0	536	1184	1514
+4369	PF01297	TroA	Lipoprotein_4; SBP_bac_9;	Periplasmic solute binding protein family	Finn RD, Bateman A	anon	Pfam-B_1416 (release 3.0)	Family	This family includes periplasmic solute binding proteins such as TroA that interacts with an ATP-binding cassette transport system in Treponema pallidum.	22.10	22.10	22.30	22.10	22.00	21.60	hmmbuild  --amino -o /dev/null --hand HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.47	0.70	-5.14	141	7592	2012-10-06 15:37:50	2003-04-07 12:59:11	12	12	3969	42	1428	5388	2851	272.40	24	83.10	CHANGED	Vlsoh.sltslscpl..uG..-.............t.spVpsll.ss.Gs-.PHsa..pssPpshpplpp...ADlllh..sG.hshE..s....a.lschh.........ttsphthl.......shsp........sl................................................................................phhtt..........................................................................................................ttttcpsp........................................................................................................................................................................................................DPH.lWhsPpsst.thspslsctLsch.......-Pppts...hYppNhppahpcLpplcpphpptls.sht.t........pphls.hHsuas..Yhscpa....GLp...huhh........thss..tpcsospcltplhctl+ppslpslFh-sphssc..hscpl...upcs.G..sp...l.......lhlcsl........................st......sYhphhpp....Nhpsltpul	........................................................................................................................Vlsohtsltshscpl......uG...-.................................p...splp....sl....l.ss....G.s-...s....HsY......cspsp....Dl...t.p....l.....pp...ADlll.a.sG..hshE.....s....a..hp+hh.................thp.ppp.hphl................tssc.....sl.......................................p..........................................................p...p.................................................................................................................................................................................................................................................................................................................................................................................................................................DPH..sWhssppuh..t.h.spsItct.L.sc.h.......DP.p.pps....t.Y.cpNhppahp.c.LppLcp.ph.pp...ph.s...sh.p........+th.l.s..pHs..Aas..Yhucpa................Glp......t..hshh..........slss...-pc....sospplpplh.ch.l..+.....c.p.....p..l.ps.....lFs...E.s..p.s.s.s..c.......sscsl.......uc.cs....u....sp...h............hhlssl....................ttt..t.tsp...sYhs.h.hcp.shpsltps..................................................................................................................	0	431	876	1187
+4370	PF04405	ScdA_N		Domain of Unknown function (DUF542)  	Yeats C	anon	Yeats C	Family	This domain is always found in conjunction with the HHE domain (Pfam:PF03794) at the  N-terminus.	28.90	28.90	29.00	30.50	28.30	28.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.56	0.72	-4.58	70	1136	2009-01-15 18:05:59	2003-04-07 12:59:11	9	6	1115	0	170	543	24	56.10	44	24.94	CHANGED	ts..pslG-lVsphspuuclFccasIDFCCGGptsLscAs.pcpsl-.stllpcLpslt	....+.spslGElshshP+A.oslFRpYclDaCCGGppoLtcAu.t++slDls.l.scLspL.t..........	0	52	104	142
+4371	PF02667	SCFA_trans		Short chain fatty acid transporter	Bashton M, Bateman A	anon	COG2031	Family	This family consists of two sequences annotated as short chain fatty acid transporters, however, there are no references giving details of experimental characterisation of this function.	20.00	20.00	20.10	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.63	0.70	-5.71	4	740	2012-10-02 15:12:49	2003-04-07 12:59:11	9	3	662	0	154	1076	192	418.50	44	98.19	CHANGED	hlpRlophhsthVSKaLPDPLIFAhLLThVTFllshsLTspssls.........lVshWGsGFWsLLuFuMQMALIlVTGpALAous.Vp+lL+plASlsKsshpulhLVTFhu.IAshINWGFGLVVGAhFA+....ElARplKGsDYsLLIAsAYhGF.lTWtGGhSGShPLLsATPspslp+lhst..s.pthIPlspTlFSuYNlhIhshlllshPFlhhMhhPKpuElhuIDs......KLltcEhc.pcpls..cDsTlA-+LEpS+lLuhlIuhLGhuYLGhYFacpGF...lolNsVNhhFlhsGlLLHtoPhAYMRAIspAARSsAGILVQFPFYAGI.hMMcaSu..lGG.....lIophFhsVANccTFPlhTFaSuulINhhlPSGGGcWsIQGPhllPAuQALGsDlGKosMAIAaG-tWhNMhQPFWALPALuIAGLGsRDIMGYClosLIFsullhslGLhhl	.......................................................................................................................................................................................ht+hsphhsphspRaLPDsal.FuhLLTllsh.l..hAh.hhs.s.psPh.p.........................hl.ph.WG......s...GFW...s..LLuFu.MQMALll..VTGasLAo.os..l++.lLp.p.h.A.p.hs..+ost.p.u.l.hh.Vo..hluhlush...l...NWGFGLVl..GAlhA+....El....A....R....+....l..c....s....s..D...Y.....LllAuAY.GF...lsWtu.G.lSuS.h......PLhhAT.s...G...p.......htchh....u....................lIPh.o-Tl..Fo.s..aslh..h.s..lsl..l.l.s..hP....h..ls.t.h..h....h.....P....c..s........p...c..s...l.s...l.Ds................pllt.c.....-s.s...h......p.....p..........h....s............................t......p..s...............s.P.uE.+LE.p.Sh.....l......L.......o...ll.l....u..h.L..G.l..s.Y.l..h..h....a..F.....p...p.G.hs.........l...s........L.N.........h.........V.....N...h..h...F....L.......h....h....G.l......L.......L......H.....t......T......P...h....s....Y.......hc.........A....ls....p...A....s...+.....o.s.u....G...I.......L.......lQF..P.F.Y.A.G...Ih.u.h..M.t.p.u.u....hs.G.................h......I...o....p..a...F....l..s.....l...A.....s.....c...c..T......F...P..l..h....s.....F..l.....S..u..u..l.l.NhFVPSGGGpWslQuPhllPAApsL.G....sc.........h.........u.........pssMAlAaG-uWsNhlQP...F....W..A..L..P..s..L..u..I.........A.........G..L...t....s....RD...I...M..Ga.....C....l....s...tL....l..hs.Ghlhslshhh...............................................	0	45	86	124
+4372	PF04486	SchA_CurD		SchA/CurD like domain	Kerrison ND, Bateman A	anon	DOMO:DM04327;	Domain	Members of this family have only been identified in species of the Streptomyces genus.  Two family members are known to be part of gene clusters involved in the synthesis of polyketide-based spore pigments, homologous to clusters involved in the synthesis of polyketide antibiotics.  The function of this protein is unknown, but it has been speculated to contain a NAD(P) binding site [1]. Many of these proteins contain two copies of this presumed domain.	24.20	24.20	24.40	45.70	24.00	24.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.21	0.71	-4.25	16	83	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	40	0	25	85	0	109.00	36	61.55	CHANGED	h.RHALoYsl+PGststlAclLu.........hps.sAssDsss.llpTolFh+-shVVRll-VcGDh.s.hhtahu.p..s.tsEpAlsPhLcpsRchu-scuhhshhtcAAhsslppsssts	....RHALoasV+PGstttlAclLA..........thps.pA..tsDssohLhpoolFh+sshVVRhl-Vc....GD.L.t.hhtahu.p..hpssEtAls.hL..cp..sRchucspuhhthatcAuhsslpphs..s................................	0	9	21	25
+4373	PF02630	SCO1-SenC		SCO1/SenC	Mian N, Bateman A	anon	COG1999	Family	This family is involved in  biogenesis of respiratory and  photosynthetic systems. SCO1 (Swiss:P23833) is required for a  post-translational step in the accumulation of subunits COXI and COXII of cytochrome c oxidase [1]. SenC (Swiss:Q52720) is required for optimal  cytochrome c oxidase activity and maximal induction of genes encoding the light-harvesting and reaction centre complexes of R. capsulatus [2].  	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.88	0.71	-4.65	6	2856	2012-10-03 14:45:55	2003-04-07 12:59:11	9	21	1787	30	1082	3642	2070	164.20	24	74.44	CHANGED	IuLllusGuthsaLh......LpTsKtspssph.....csplsGPFpLh-.pGc.Fsp-sLpGclSLlYFGFTpCPDICPstLc+lsshlcpLcpc.pIclQslFIolDPcRDTPcVLKcYlpsFcsuFlGLTGshcplKslsccaKVaasps.ssKssp-YhVsHSsFhYLIss-G+hlcta..shs	..............................................................hhhh................................................................................h....s...F....pL.h....s....p...s.G...p.......h...s.....p...s...h....c...G....+....h.hl...............l.a.FGa.TpC..P..D..l..CPs...p...lsp...h....s.ph...h..........c..........p..........l...sp............p......t.......t.......c...........l..p.sl....F....l....o..l...D....P..c......R.......D.....T....s.......p.h.L..p.......p....Y....s.....p...t...F.....s.....s.....p.....h.....h..u.....L...o...G....s..........p.........p.......l.....p...p.....h.....s.....c......p......a......p......l.....h.a....p.....p............s.......................................................................t......t................s...............Y.h....l...sH...........os......hhaLls...pGph.........th...................................................................	1	322	667	895
+4374	PF02036	SCP2		SCP-2 sterol transfer family	Bateman A	anon	Pfam-B_1050 (Release 5.1)	Family	This domain is involved in binding sterols. It is found in the SCP2 protein Swiss:P22307, as well as the C terminus of Swiss:P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Swiss:Q17372 contains an SPFH domain Pfam:PF01145 [2].  	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.11	0.72	-3.72	174	3603	2012-10-02 14:08:01	2003-04-07 12:59:11	12	54	1915	19	1132	2747	690	100.00	20	46.14	CHANGED	lsplhpt.......p..tttstlpplsu.......shphpl.psh.h.....shhlshp...ss.phpl........hst.t..psD..sslshsssshhplhsuc....sspphhhps+..LclcG.Dhtluhclpslhp	.............................................................................................psthptl.pu...............hlplcl..pshsh....................phhlshp........st..plpV................httht...tpsD..solps..s.ss..s.....Lht.lh..stc.......ss.ssh.hhps+..Lc.l.c.G.Dh.pluhplpslh............................	0	351	606	884
+4375	PF00375	SDF		Sodium:dicarboxylate symporter family	Finn RD	anon	Prosite	Family	\N	19.80	19.80	19.90	20.00	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.42	0.70	-5.71	135	10806	2009-01-15 18:05:59	2003-04-07 12:59:11	13	12	3666	24	2273	7267	1474	380.50	26	90.76	CHANGED	L...hhplll..ulllGlllGh......................................h..hsphsshlp.hhGslFlphlphlllPL.lhsollsuluslts..scplG...+luhpslhhahhooslAshlG.lhluhlhpPG..........................stts..........ssststpstpssshhp....hlhshlPsN.......hhtuhs........ps....................................................................slLslllFullhGlulstlsp..cs........cslh.phhcshpclhh+llphlht.luPlGlhulhAthsup.hG.....hshlh.sluthllsshluhhlhhhllhslhhhhhsph.sPhch.h+thhsshlhAFuTsSSsATLPlslcssccph..........G..VscplusFllPLGsTlNhsGo.ula.ulsslFl...AphhGls.lo.hsphlhlllssslsSlGsAGVPGuulls.lshlLs..slG...lP.....h.pu....luLllul-hll.DhhRTslNVs.GDsssuhlls+h	.............................................................................hhhplll.u.lllG.l.llGh......................................................................................................h.h..t.h..s..p..h..h.....p...lGsh.FlphlKMllhPl.lhs.ol.l.s..u...............lus......h.tp...........hpphG........+l.u.hh.sl.hh.a.h...h.s.ohl.AhhlG.ll.hu......lht.Pu....................................................................hh..ts.........................tt.s.s..h.s.s....t.s..p..s....s.l.hp........hl.h..s.h....l...P...s...N.......hhtuhs........ps............................................................................................................................................................................................................................................................................................................................................................................s.hlsl.lh..FulhhGlu....ltt....hspps....................pslh..phlpsh..sphhh.p.l.l.p.h.l.h................p...hAPlG.l..hulhutslup..hG...........hs.slh..sl.u.phlls.hh.hshll.h.hhll.hs.l.l.h.h...h.s..t.h..s.............sh.p.h...h+t.l...t...ps.hl.....hAas.T...pS.....S...tu...slPhshc...phcc..h......................................G..ls.csls...uhs.lPhGho.hNhsGs.ula.sh.sslhl.......Ap.s..h.........G..l..s...l....s....hsp....h.l.hl..l........l........lh.hl.sSh....G.............s.A.GVsG.........uuhls..lshsLs....shG.......lP..............h...ps.......lullhu....l-h.....lh..D.sRTs....lNlsGss.lsshllup...........................................................................	1	579	1152	1742
+4376	PF02982	Scytalone_dh	Scytalone_DH; 	Scytalone dehydratase	Griffiths-Jones SR	anon	Structural domain	Domain	Scytalone dehydratases are structurally related to the NTF2 family (see Pfam:PF02136).	20.20	20.20	20.30	20.40	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.20	0.71	-4.65	3	125	2012-10-03 02:27:23	2003-04-07 12:59:11	9	3	89	20	62	135	1	145.70	58	84.45	CHANGED	sITFcDYLGLpssLFEWADSYDSKDWDRLRKlIAPTLRIDYRSFLDKlWEAMPAEEFlAMISDKsVLGDPTLKTQHFIGGSRWEKVSDTEVIGHHQLRVPHQ+YTDoThpEVslKGHAHSsNhHWYRKVDGVWKFAGLKP-IRWuEYDFDcVFcDGR-Sa	......................sap-hhuhppssaEWADSYDoK..........DWDRLR+CIAPTL+.........lDYRSF.LsKh..W..EAMPA-EFlAMhSDssVLGNPLLKTQHFl.Gu.o+WE+lSDsEllGaHQLRVsHQ.+Y.......TDso.....hsp..VsV..K......GHAHShNpHaY+Kl-GlWKFAGltPtl.a.phph..............................................	0	7	26	50
+4377	PF03313	SDH_alpha		Serine dehydratase alpha chain	Bateman A	anon	Bateman A	Family	L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyses the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.	22.20	22.20	22.20	22.60	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.76	0.70	-5.37	152	6294	2009-01-15 18:05:59	2003-04-07 12:59:11	10	13	3519	0	918	3774	323	283.70	38	69.93	CHANGED	pcp.slsluphhhcNEhs.htssp.p.lttthsphhssMtssscpGL.....ps.pGlhsGslphh+chh.........................................................................................................................ph..tppL.t.................................tt.................................hthhshshhhAhAssEtNAuGGplVssPTsGu.....uGllPuVlhhh.cchph.................................................s-.-plhchLhsuuslGhllKpsAoluGAtsGCQuElGsAsuMAAAulstlhGGoscQlppAuphulpphLGLsCDPluGhVplPClcRNAhuAspAlsuAphA.hts.s.t..ptIshDcVlcoMtpsGpshssth+ETupGG......LAhs	....................................................................................................................................................................................t.p.shslutlhhpNEhs.ht....spp......c...lttthsphhpsM...p...s...sl...c+...Gh.........ps..c.G.lh.s.Gs.l.p.h.h.R+hh.......................................................................................................................................tl...pctL......................................................t..ht.p.c................................................................s...htshs.hlshaAlAVsE...p..N.Au.G.G..pl.VsuP..TsGu...........sGllPuVLhhh...c+at.h.....................................................sc...-phh.+aLhsA..u..AlGhlhK...pNASISGAEsGC.......QuE........VGsAsuMAAAGlstl.h.G.............G.o...............Pp..Q..l....s.AupluhcctLGLsCDPVuG.V.plPClcRNAhu.AspAlsAAcMA..lpt....s.st...stl..s.l.DcVIcoMhpsG+sMs.spa+ETucGGLAh.h.......................................................................................	0	290	558	751
+4378	PF03315	SDH_beta		Serine dehydratase beta chain	Bateman A	anon	Bateman A	Family	L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyses the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.	21.40	21.40	23.00	22.00	18.90	21.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.13	0.71	-4.17	190	5230	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	3484	3	788	3051	241	140.80	39	37.95	CHANGED	SlF.Dlap.IGIGPSSSHTsGPM+AAphFhpt.lt.............................p..........psp+lplpL..aGSLAhTG+GHuTDpAllhGLhGhpP-slchc.............th..hhtthttpt.l.h...............s......ptlpFs.p.pslhachcphh.s....hHs..Nuhphp..........Ah...sssthlhppsaYSlGGGFl......hs..p...pttst	..............SlF.Dlap.lsIGPSSSHTsGPM+AGptFhst.Lt...............................................p............pss+..lpl..cl..YGSLuhTG+GHsTDhAllhGLhG.pPpslclc..............h..hht.h.tptpl.h.......................tt.......cpl.pas..hp..p..s..l..h..a..c......p..p.l...s.......hH....NuMplp.............Ah.....tss..p.....h....l...hp.p...TaaSlGGG.FIhscc...t...........................................................	1	238	475	648
+4379	PF01127	Sdh_cyt		Succinate dehydrogenase/Fumarate reductase transmembrane subunit	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite & Structural domain	Family	This family includes a transmembrane protein from both the Succinate dehydrogenase and Fumarate reductase complexes.	25.20	25.20	25.30	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.95	0.71	-4.28	125	5134	2012-10-03 07:11:12	2003-04-07 12:59:11	17	5	2968	88	1395	3246	2736	114.00	19	77.37	CHANGED	hphp+P...........hs.ph......thhp.....p..hsshh.lhpRloGlsLhh.hhhhlhh........h.h.hhhht.sst.sasth.........tshhs..........hhhlh.hhhhhshhaHhhsGl+pllh..D...h.hh......pss........ttps.hhhl.shshhhhhhh	.................................h.........................ht..............ssh.t...l.hpRl.oGlllhl......hhhlhh................h.h.....hh...hs...sth...s...apth.................tshhss........h.hht.hhh..h.hhlhulhaHshsGlp..pllh.....D...h...h.........cst.............thph...hlhh...shslhlslh.s.......................................	0	374	831	1144
+4380	PF02810	SEC-C		SEC-C motif	Aravind L	anon	Aravind L	Family	The SEC-C motif found in the C-terminus of the SecA protein, in the middle of some SWI2 ATPases and also solo in several proteins. The motif is predicted to chelate zinc with the  CXC and C[HC] pairs that constitute the most conserved feature of the motif. It is predicted to be a potential nucleic acid binding domain.	20.40	20.40	20.60	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-6.81	0.72	-4.38	183	7596	2009-09-11 12:15:01	2003-04-07 12:59:11	10	82	3806	5	1631	5164	1418	20.10	67	3.86	CHANGED	RN-sCPCGSG+KYKcC.Cttht	.....RNDPCPCGSGKKYKpC.pGp..t.....	1	545	1051	1369
+4381	PF00995	Sec1		Sec1 family	Bateman A, Griffiths-Jones SR	anon	Pfam-B_530 (release 3.0)	Family	\N	20.20	20.20	20.40	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	564	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-13.08	0.70	-5.88	150	2115	2009-01-15 18:05:59	2003-04-07 12:59:11	18	29	328	14	1402	2034	44	467.10	18	86.95	CHANGED	hKlLll..Dptstslluhshphs-Lhpps.Vslh...................tplcs..........................pR...............psh.shpslahlpPs.tcslctl.hp-...................lpp........................................spYppaalhFss..................shs..cshhcpLupss.............shptlpplp-....hhlcals...l-sslF.....oL.....p..hs.............................psa....tthhs..............................................................................................pttppslp....phupuLhsl.hhohsp...........hPhIRhpts....................................................hucpluptltphlpct.........p.htttpps.t.........................................sl..LlIlDRshDhloPLlppaTYQuhla-llslpp...splpl..........psst.ttp............................+.phhLss..pDthasphpttpasclsp...plpphlpcap..p.p..............................ppppttshs.clpphlpp.lPphp.cppsplshHhslssplhpplppcp...Ltc.hhclEQslss.ssststp.....hhp.lhch..l.............ssp.....h...-+LRLlllahlp.....t.t..spphpphpchlpps..t.hs.pph.....thlpplpphsthht..p.................................t..............t..pp.tht.h.......thhpth.pt..p........................ssp.hhsp.ap.......................Phlppll-sl...........................hpsph..sppashhssps.................................t.t...tt........................................................pph....pcllVFllGGsTYsEhpslt.plspptt.................................h.clllGuTsll...........ssppFlp.pl	.........................................................................................................................................................................KhLlh..Dp.........hht...ls...h.h..p.....ptlh.p.....t..l.h.h......................lpp.................................pp.....................t.h..ph.....slahl.p.......P....p...............ps.....l..phl..hpc.....................................................hpp..................................................................................hhpt.h..alh....Fss....................................hs..t......h..h...p.l....tptt...........................t.l..t.t.l...-............h.h.sa..hs....h-splh...sh...............p..................................s.h......th...................................................................................................t.t.t..lp.....thsptlhsl.....h.s.h.t....................hP.h.l..ph.tt.....................................................sp..hlsp..lt.p.h.hpp.....................h...p.p.......................................................................s....LlllDRshD.hoslhpp....hTYpuhhp-l......h...s....l....p......t......s..t...hph........ps...t.t.............................................................c.ph.Lst...pD.ha..p..tt.ph.spl..st...tlpp.hpphp....tp..............................................tptt.tsht....chpphl....pp.hPphp.p..tt...t..hs.h..Hh...slspt......h..ph.hp.....t.pt.................h......p...hhphE.....pplh....t.s........ptt.....................p.....h.ch.l..........................................................stt.h.s..stl.Rl.h.h.l.h.hh.......t....t.......t.ptht..p...l....ps...............hs.......pth..............hlpphtt..hsh.h.t...................................................................................tp..ht.....................t...tt..p...........................................t..p.........h..st..at.......................shltplhpph.....................................................hpt.t..........ppt.a..h.h..ps............................................................................................................................................................................................tpth.phllFhl...............GGsoh.tEh..tsh.h..hspt.t............................................hclllusoplhsspphlpt................................................................................	0	535	782	1152
+4382	PF03908	Sec20		Sec20	Wood V, Griffiths-Jones SR	anon	Pfam_B-21631 (7.2)	Family	Sec20 is a membrane glycoprotein associated with secretory pathway.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.89	0.72	-4.28	6	380	2012-10-01 21:14:52	2003-04-07 12:59:11	8	5	278	0	245	459	5	90.80	25	29.24	CHANGED	SpspplTcuLhshpphhspslppSs.slpsLssSTpsLpphs-capphpsllppo++LlKphp+p-psD+hllaluhuhFlhsVsYlVhKRI	.....................t..spplTp.uLtcspphhspplppS.p.shpsLp..........pSopslpphspcap.s......h.ss..............hlppu+pLlpphtRpphoD....+....h.l....l....h.hu....h..h.hhls..s.lhallh+Rl...........	0	69	131	200
+4383	PF03911	Sec61_beta		Sec61beta family	Yeats C	anon	[1]	Family	This family consists of homologues of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG. It consists of a single putative transmembrane helix, preceded by a short stretch containing various charged residues; this arrangement may help determine orientation in the cell membrane [1].	19.20	19.20	20.20	20.70	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.80	0.72	-4.15	33	504	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	411	11	343	453	48	40.20	40	41.61	CHANGED	ouuull+aYs-.-sp.GlKlsPhsVlhhSlsaIshVllLHlhu	...........uushl+aYT-.-us.GlKlsPhsV.Llh.SlsFIssVhhLHlhu...........	1	104	195	283
+4384	PF03839	Sec62		Translocation protein Sec62	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	22.40	22.40	22.40	22.50	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.72	0.70	-4.94	6	341	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	280	0	226	348	2	199.00	29	55.86	CHANGED	sK+phFFRsK+ll+hLpstchKppKsKspsc.s........K...psp-cppchhKphhpss.s.tscK.....l.sppttp.cKKc.pKclc.Lpl.pcsQhFsD.s-hYVWlY-PlPhpsalhGllhllull.AhsLFPLWPhhhRpGVYYLSlGuhGhlushhslAIlRhILFl...IlaslshG+.thWlFPNLhtDVGFl-SFpPLYsachp.s.p+sphKKccKsKpKKKcKss	.................................................................................h....ha+hh.+h..h..hh.p.th.tttt....p...t.........................t......pt.p....h..p.p.....h...t.......h.....hp..h.tsp+......................tp........t..p.t.t.c..c......p+..ph+....L.ch.....pt..cQhhh..D...s..t.hY.VWlY.-.s.s....p.hhphlhuhlh..llull...AssLFPLWPhhhRhGV....a.YLSlushuhluhhhslAl...............hRhIlFh...lhahhs...h.thWlhPN.Lh.p.D.l.GFh-SFpPlasap.p.......pt.p...Kp.p.t+t..........s.................................	0	76	124	185
+4385	PF01369	Sec7		Sec7 domain	Bateman A	anon	Pfam-B_1629 (release 3.0)	Domain	The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the Pfam:PF00025 family [2].	21.10	21.10	21.20	21.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.26	0.71	-4.63	140	2266	2009-01-15 18:05:59	2003-04-07 12:59:11	15	40	354	21	1387	2049	18	181.20	34	16.19	CHANGED	p........pth.................c...h.........pshptFs......pp..scculphlhppsh.h..................ttpsspp....lA..........pFL.t.psss...........ls+ptlG-aLuc...tpshs.................................hplLctalch.acFp..................shslspALRphLppFcLP....GEuQpI-RllcpFu....................................p+Yh..........................................................................................................................................................................p.sN.........s.........................................sh.atss..Dssal...LuaullMLNTDLHNs.p....l+.p+........................MohpcFlcNsc...........................uhs.........supc.hsp-hLpplYc.........sIpppcl	....................................................................t........h.....uhphFN.p.....Pc.......cGlphL.ppshl..............................................tpss.pp.lA..............pFL..h..ppcs...............Ls..+..phlG-aLGc......ppphs..............................................................hpVLc.s.al.ch....a-Fs..................s.h.p.lspAL.R...............pFL..t..p..F+LP......G.E.u.Q.c....I-Rl..h-.tFu...............................................pR.Yh...................................................................................................................................................................................................................p...CN...Pt....................................................................................................................................hFtss....Dssal....LuaulI.hLNTDlHss..s.........l..+...cK.........................M.ohccFlcN.+.................................................Gl.s........sG...p....D..lsc-.......hL..........pslYppIppp.h.....................................................................................................................................	0	457	692	1048
+4386	PF01043	SecA_PP_bind	SecA_protein; SecA;	SecA preprotein cross-linking domain	Finn RD	anon	Pfam-B_507 (release 3.0)	Domain	The SecA ATPase is involved in the insertion and retraction of preproteins through the plasma membrane.  This domain has been found to cross-link to preproteins, thought to  indicate a role in  preprotein binding.  The pre-protein cross-linking domain is comprised of two sub domains that are inserted within the ATPase domain [1].  	23.00	23.00	23.20	23.00	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.58	0.71	-3.72	120	5736	2009-01-15 18:05:59	2003-04-07 12:59:11	15	29	4782	29	1118	4232	2582	118.40	41	14.40	CHANGED	s.scp...ssphYppssplsppLpc..s.....................DYplDEKs+sltLT-pG...hp+sEchh.....hl.......................................ssLYsspsh.phh+alppAL+A+tLFp+Dh-YlV.c.Ds....c.....VlIVDEFTGRlMtGRRaS-GLHQAIE	.....................................................s.ppsophYtpsscll..p.L.p.c..p..........................-YplDEKs+sltLT.EpGl.pc.sE.chh......tl...................................................................-sLY.s.s...p.Nh.....sLh..Ha..lspAL......+A+hLap+DhDYlV......p.....-.G..........E.............VlIVD.E.aTGRhM.t......G.RRaS-GLHQAlE.........	0	393	750	958
+4387	PF02556	SecB		Preprotein translocase subunit SecB	Bashton M, Bateman A	anon	COGs	Family	This family consists of preprotein translocase subunit SecB. SecB is required for the normal export of envelope proteins out of the  cell cytoplasm [1].	20.80	20.80	21.50	21.30	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.78	0.71	-4.61	114	1987	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	1915	16	404	1065	1207	142.90	37	93.68	CHANGED	Mu-ppp..................tPp.hslpphYlKDlSFEsPsuPplF..tpphpPclslplsssuppl...............s..-shaEVsLplslsu+hp..pp.............ssFlsElp.AGlFpI........p.slsp.-plp.hLtltCPslLFPasRchluclspcGGFPPLhLsPlsFsALYppp...h......tppps	..................................................................................p.tFpIp+lYsKD..lSFE.sPsuPplF.....ppch...pPclp..lsl.sstup.pL...............u...-sha.E..VlLpl..oV..o..u.p.s.-c.............ssFlsEV..p.Q.uG..IF.s.I.........t..s.lps.p.ph..sph..LushCPsILFPYARcsIoshls.+.Gs.F.P.tL.L.s.PlNF-ALahphhpppt.t.............	1	112	227	308
+4388	PF02355	SecD_SecF		Protein export membrane protein	Bashton M, Bateman A	anon	Pfam-B_844 (release 5.2)	Family	This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.90	0.71	-5.10	19	8057	2012-10-02 18:57:54	2003-04-07 12:59:11	11	21	3723	9	1953	12076	6096	184.70	28	42.02	CHANGED	thpshhcshss.shphhphchVGPsluppLtppulhAlhhAhlhIhlYlslRFch.hAhuAllA.LhHDlllslGhhulht.....l-lshssluALLTllGYSlNDTlllFDRlREs...hp+.pptshpclhshulspTLoRTlhTohT.....sLlsllsLhlhGu.....sslpsFuhshllGllsGTYSSlalAssllhhhtpc	.............................................................h..hhh..............h.phhp.tcsV....GPs..l.G......p.-..h...h....p...p....u....l....h....A...h.....l...l.u...l....l....h..l..h...l..a...h..h.h....h...a.....c.....h.....t.....h.........u....l..s...A....l..lA....L.......h..t..s..l...l..l..h...l..u....l...h...u....l..h..t................hpl...s..L..s..s..l...A..u....l..lh..s.l..Gh..u..l..ss.sl...l....l...a-...R.I...REp........................l..+...p...................s....p....s...h.....t......p....s.l.s..p....u...h...s...p...s...h....s...p....h..l...s.o....s....l.T........T...l..l...s.s..l....s....L...a...h....h....Gs.............us.l...+..G......F....A...l.....s....l.hl..G..l.l....s..u.h....a.o.ulhlupslh.hh...hh.........................................................	0	650	1298	1669
+4389	PF00584	SecE		SecE/Sec61-gamma subunits of protein translocation complex	Birney E	anon	Swissprot	Family	SecE is part of the SecYEG complex in bacteria which  translocates proteins from the cytoplasm. In eukaryotes the complex, made from Sec61-gamma and Sec61-alpha  translocates protein from the cytoplasm to the ER.  Archaea have a similar complex.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.50	0.72	-4.39	185	4664	2009-01-15 18:05:59	2003-04-07 12:59:11	15	11	4540	10	1213	2641	1958	56.60	28	61.98	CHANGED	phhp.FhcpspsEl+.KVsWPo+cEshpsThsVllhlllhulhlhhlD.hhhthll.phlh	............h..hp.Fh+pstpEl+.KVsWP.........o+cEhhpsTlhVhshshlhu....lhlas.lD.hllstllphl.............	0	411	783	1027
+4390	PF03840	SecG		Preprotein translocase SecG subunit	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.50	21.50	21.70	21.60	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.46	0.72	-4.24	183	4339	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	4294	4	929	2471	1834	73.50	31	72.34	CHANGED	hsllhllhlllulhLlslVLlQpuKG.uuluush.GGGu..stolFGup.sutsh...Ls+hTslluslFhlh.ulsLuhlsp	.......phLlllhlllulhllhllLlQpu.Ku.ushuusF..uuGu.....ptslFGsp..tut..sh....LsR.hTs.l.Lu.slFhlh.slsLuhl...........................	0	319	620	789
+4391	PF04856	Securin		Securin sister-chromatid separation inhibitor	Mifsud W	anon	Pfam-B_4643 (release 7.6)	Family	Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss [1].	20.30	20.30	23.60	33.30	18.90	18.20	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.90	0.70	-4.65	8	108	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	70	0	48	106	0	208.00	36	95.25	CHANGED	hssllhss+EN......usPsstlppscuhh.............................................+.PLuStsp..s+opu................................................tssshpL.+h...Gplhs.shslspsspKuLsshD....pslpsKsst..........pscpsshsscshs.puKKlpuu................................................schshEhhPchp+.hPapP.GaE..uFD........s.-cplp+LsLps..........sPht.....h.hhs--ptptp.hpl.s.sP.......................Lc.ssls.cus.............................................shsuLssl-l	..................................................MssllassKEN..........tpPu.pp.lsspculh.................................................Luotss......hKuhs....................................................tpsplshs+h...GKshss..s.....u.....ls.KssRKuLGsVs....tpsscspssh..................................pp+psshss.cc..hocpss..Kspou.............................................................sssss-saPEIEc..hhPasPl..sFE..oFD.......hPtEcpIu+LsLss..........lPLh.......h.pE-.c..c..pc...phss..P.......................lch..sp.s.E.us..........................................................hhps..............................................................	0	6	13	23
+4392	PF00344	SecY	secY;	SecY translocase	Finn RD	anon	Prosite	Family	\N	22.20	22.20	22.30	22.20	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.15	0.70	-5.52	157	6369	2009-01-15 18:05:59	2003-04-07 12:59:11	15	14	5237	19	1533	4121	3873	333.00	34	79.26	CHANGED	olhuLGIhPaIoASIIhQLL...................shspLtclppp.GcpGRc+lsphoRhhollluhlQuhuhshhhtths.........................hh..lhhll..pLssGohhlhWLuEhIoc.hGl.G.NGlSLlIhsuIl.sslsts................................lh...phhphh......................t..hshhh.........h........lhhllhhlhl.lhhllalppup++IPlpas+p..............tsp..psa.lPlKlNhuGVlPlIFAsul..lhhPt...hluphh......pt......................................t........hhtp.lshhh...................................hpshhY.hhlahshhlhFuaFas.shshsPc-lAcsl++pGsaIPGlRPG.csTpcaLs+lls+lohhGul.aluhlullP..pllsshht..........................h..huG.TulL....IhVu....lsl-...hhp	..............................................SIFALGIhPYIo......ASIIhQLLp.................slhPpltc.hpKp.G-tGR+KlsphTRY.hTllLuhlQuhuhsh...shsshssh.t.......................................shh..lhhslhLssGohhlh.......WLGEpITc.+Gl.G.NGlSllIFuGIluslPts............................................lh.p.hhpthh.........................................p..s..t..h.shlh.......h.........lhlll.hhlhl.hhhllalp........pupR+I.P.lpYu++................htsp..soalPLKlNhA..GVIPlI....FASSl..lhhPt....sls..pah..sss.................................................t....hh.t.p....lst...hh...........................................s.spsla...hllYsshIlhFsaF...Ys..slt.hNPc..-hA-.....NLK....Kp.Gual..PGlRPG.cpTtcYlscllsRlTh.hGul.alshls.llP...h.htthhs..........................shh...hGG.TS.LL....IlV.sVsh-hh.......................................................................	0	523	976	1295
+4393	PF04628	Sedlin_N		Sedlin, N-terminal conserved region	Mifsud W	anon	Pfam-B_5308 (release 7.5)	Family	Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400) [1]. This family represents an N-terminal conserved region.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.85	0.71	-4.29	32	687	2012-10-04 00:47:01	2003-04-07 12:59:11	8	10	305	4	469	992	6	133.60	27	84.69	CHANGED	IlGp.....pDsPLaph-Fssst..ps...........................................ppL...tpFlsHuuLDll--hhap..................................ssshaLttlDpa....pphhl.oualTsuplKFlllap..................................................shs-ssl+pFFp-la-hYlKhlhNPFY..........................p.ss............sIp.Ss.....sF-p+lppluc+	............................................................................................................................lluppspPla.hphss.tp..p.t.t....................................................................................t.l....palsHuuLDll--thht.......................................................................ssshaLt...........hl....p.ph.......pp..h..hl...u...a.l..........T.s......o.......p.......l......+..Flllhc..............................................................................shp-...ssl.+...s......h.Fpcla.ph.Yl.c.h.h.h.NPFY............................p.s..ss.................Ip.S.......tFcpplp.hh............................................................	1	166	259	386
+4394	PF00477	LEA_5	seed_protein; 	Small hydrophilic plant seed protein	Finn RD	anon	Prosite	Family	\N	20.60	20.60	21.10	20.80	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.65	0.72	-3.78	5	271	2012-10-01 20:07:30	2003-04-07 12:59:11	12	10	102	0	87	294	3	71.90	39	87.44	CHANGED	MASG.........QEcREELDcRAKQGETVVPGGTGGKSLEAQEHLAEGRS+GGQTRKEQLGoEGYpEhGoKGGpTR+EQhGpEGYpEMGRKGGLSTpDcSGuERAA-EGI-IDESKF	....................................................................................Eu..tp....+GGpsppcphGcEhYpEhGpKGGp.sptcphsp-hYpEhG+KGG......u..s.p.p...................................................	0	20	59	77
+4395	PF03841	SelA		L-seryl-tRNA selenium transferase	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.03	0.70	-5.72	11	2029	2012-10-02 18:26:03	2003-04-07 12:59:11	8	7	1584	2	363	1893	697	327.50	37	78.46	CHANGED	VlNhTGsVlHTNLGRAlhu....-cAhpAshpuhpc.ssLEaDL-sGKRGsR.salpcLLpcLTGAEsuhVVNNNAAAVLLsLsolApGKEVIlSRGELVEIGGuFRIPDlMcpuGs+LhEVGTTNRTHl+DYcpAIspNTAhLhKVHoSNYplpGFTppVsht-LstLu+EhslPlhpDLGSGsLlDLspYGlst.EPTVp-tlupGsDlVoFSGDKLLGGPQAGIIVG+K-hI-+lpppPLpRALRlDKlsLAuLEATL+LYlpP-+htc+lPTL+hLopshctl+tpApRLpthLtstLu.t.hpVpltsuhuplGuGShPhpcLsShslolpscps......slsuLptthRths.PlIGRlc-stlhLDlRoLt	.............................................................................................................VhNhoGsllHTNLGRu..s....ttshpshtpshpt.ssl.E.h......sL.p......p..u......t......R.......u..p.R......p.....h.....l.t.p......h.........l......p.p........ls.u.....A...E.......s.......A....h.......lV.N.......NN...A..A.A.V............h....L.........h.l....s.................s.h....u................p.s................+................E....VVl........S..........R........GELV.EIGGu.....F..R..l....s..-.l.h.p.t...........u.....Gs..pL......h..E..V..G........o......o..N....+...T...+...h..p..DY...c.....pAI......s.E...p..T.Ah..L..h+V...H.SNaslpGF..pptl.sht-ls.t.l...u......+c...........t.............s.........lPllsD.lGS.G...h....c.h.........t.hh..h.....Es.t.h.p.phl.tsGsDLVsFSGDKll...GG....P...Q...A...G.lIl.GK....K.p.....hI..s....p.....l.....p......p.....p......s......L....t..RAl....R.lsKh.o.Lu....uLpss.L...chY.l....p........p..t........p.plss..hph..Lp.ts....t.lt.tA.p.l....lt..................................th..s.u..lGuGs.hP....l.shhh.h......................tht..h.+........sllsRh.pt.hhh-hpsl.t..................................................................................................	2	127	232	306
+4397	PF04593	SelP_C		Selenoprotein P, C terminal region	Kerrison ND	anon	DOMO:DM04433;	Family	SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [1]. It is thought to be glycosylated [2]. SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity [1]. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage [2]. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function [3]. The N terminal region always contains one Sec residue, and this is separated from the C terminal region (9-16 sec residues) by a histidine-rich sequence [2].  The large number of Sec residues in the C-terminal portion of SelP suggest CC that it may be involved in selenium transport or storage. However, it is also possible that this region has a redox function [2].	19.20	19.20	20.70	49.00	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.37	0.71	-4.36	4	16	2009-09-13 02:32:08	2003-04-07 12:59:11	9	1	10	0	6	37	0	124.80	54	34.28	CHANGED	GQHRQGH.EssDhs.ASEuLQ.SLsQ+KLUR+tCINQLLCKLsc-SEuAsSSCCCHCRHLIFEKoGSAITUQCsENLPSLCSUQGLhAEEpVhESCQsR.PPAAUQ..uQplsPTEASssUSUcNpsKKUKUsSN	............................G.pRpGH.-spDhs.uSEslQ....Q+KLsRK..RCINQLLCKhscDScsA.uSCCCHCRHLlF.Ec.oG.SAlTUQCsENLPSLCSUQGLhAEEN.lhESsQsR.hPPAAUph.SQ.hsPsEA.sssUuU+ppsthscs..N.	1	1	2	2
+4398	PF04592	SelP_N		Selenoprotein P, N terminal region	Kerrison ND	anon	DOMO:DM04433;	Family	SelP is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues, and accounts for more than 50% of the selenium content of rat and human plasma [1].  It is thought to be glycosylated [2].  SelP may have antioxidant properties.  It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity [1]. The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage [2]. The promoter structure of bovine SelP suggest that it may be involved in countering heavy metal intoxication, and may also have a developmental function [3]. The N-terminal region of SelP can exist independently of the C terminal region.  Zebrafish selenoprotein Pb (Swiss:Q98SV0) lacks the C terminal Sec-rich region, and a protein encoded by the rat SelP gene and lacking this region has also been reported [2]. N-terminal region contains a conserved SecxxCys motif, which is similar to the CysxxCys found in thioredoxins.  It is speculated that the N terminal region may adopt a thioredoxin fold and catalyse redox reactions [2]. The N-terminal region also contains a His-rich region, which is thought to mediate heparin binding.  Binding to heparan proteoglycans could account for the membrane binding properties of SelP [1].  The function of the bacterial members of this family is uncharcterised.	22.90	22.90	23.40	23.30	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.84	0.70	-4.98	6	83	2012-10-03 14:45:55	2003-04-07 12:59:11	9	4	48	0	49	89	1	177.60	34	63.13	CHANGED	QspSShCK.PPpWpIcDpsPMhNuhGpVTVVALLQASUahCLlQASRLpDLRlKLcppGYoNISYhVVNcQu.pSphhascLKc+luEcIPVYQQ-.sQsDVWpLLNGsKDDFLIYDRCGRLsYHLuLPaSFLoFPYVE-AIKtsYCEchCGNCSLso.ps.-.CKssTh...........tsssKssEsp.....sct.HsH.....Ht++HsHsHcH.s.....ssphpcs.pss.sstsp.Ps..uh.HHHH+H+	...........................................................................hs.h..............h..phtsLp.+Ltpp....Gh.slpahlVN....pps...Sp............h............ha..Lpp.......pss......tl.......sVYp...Qp.tpsDlWphLsGs...KDDFLIYD..RCGRLs..YHlsLPaS....hL...pasYVEtAI+hsYpcphCGsCo...hp.s............t...s......p.spth......................t.pps..p............t.....p.......................................................................................................................................	0	10	14	34
+4399	PF01641	SelR	DUF25;	SelR domain	Bateman A, Enwright A	anon	Pfam-B_1539 (release 4.1)	Family	Methionine sulfoxide reduction is an important process, by which cells regulate biological processes and cope with oxidative stress. MsrA, a protein involved in the reduction of methionine sulfoxides in proteins, has been known for four decades and has been extensively characterised with respect to structure and function. However, recent studies revealed that MsrA is only specific for methionine-S-sulfoxides. Because oxidised methionines occur in a mixture of R and S isomers in vivo, it was unclear how stereo-specific MsrA could be responsible for the reduction of all protein methionine sulfoxides. It appears that a second methionine sulfoxide reductase, SelR , evolved that is specific for methionine-R-sulfoxides, the activity that is different but complementary to that of MsrA. Thus, these proteins, working together, could reduce both stereoisomers of methionine sulfoxide. This domain is found both in SelR proteins and fused with the peptide methionine sulfoxide reductase enzymatic domain Pfam:PF01625. The domain has two conserved cysteine and histidines. The domain binds both selenium and zinc [2]. The final cysteine is found to be replaced by the rare amino acid selenocysteine in some members of the family [1]. This family has methionine-R-sulfoxide reductase activity [2].	21.90	21.90	21.90	22.00	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.52	0.71	-4.43	18	5387	2012-10-01 21:11:27	2003-04-07 12:59:11	13	18	4111	31	1382	3866	2926	121.70	48	59.33	CHANGED	c-Eh+psLos.QacVhpppuTEpPaTsEYscpaEcGIYsslssGpPLFpSpsKF-SGCGWPuFhcPlspcu.IphptDpShsMpRsEVpstssDuHLGHVFs.DGPpp....ssGhRYClNSAuL+Flst	.......................................t.tch+ppLo.s...pYtVspcpGTEtP....F.....o.uc....Y...h........c.....p.....t.c...p.........GlYss.h..ssGpPLF.....pS.p.....sKF...-...SGC.........GWPS...Fhc.P.............l.......ss....p.......s........l.......p..htp.......D.......t.S........a............G..............Mt.RsEV+stpssuHLGHVFs.DG..P......ps........s.GlRYClNSsuLcFhs.t........................	0	441	862	1147
+4400	PF01403	Sema		Sema domain	Bateman A	anon	Bateman A	Family	The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance.  Sema domains also occur in Swiss:P08581 the hepatocyte growth factor receptor and Swiss:P51805	19.10	19.10	19.10	19.20	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	433	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.70	0.70	-5.96	26	2637	2009-09-11 14:23:39	2003-04-07 12:59:11	14	95	167	27	1239	2166	0	367.60	25	40.30	CHANGED	aphhhhc.tpspLaVGA+stlasLslpslp....ph...pplsWsus...ppppcpChh+GKs......ts-CtNal+lLtshsps.+LhsCGTsAapPhCphh..plss.....................................aph.stpp.sGpucCPasPppspsulhs.s.....sp......LYuuoshD......Fhup-ssIhR.hu........ptssl+Ttht...sphhLstPpFVsuasIs.s.t......pschlYFFFpEsus-tt.ts....tcslaoRluRlC+sDhGGpchlp.spWooFLKARLsCShPu..t.s..haFspLQssahl.sss..........pssllaGVFoTspsshtu....SAVCsaslpsIppsF.pGsatpp...csspppWhshps.chP.PRPGpCsssst.........thPDpslsFh+sHsLMtpsl.slpptPlhscpssphphTpIsVD..plpstssp.asVhalGTspGpll.hhlslspss..s...hhlEEhplhpss....tPlpshplsppp	.......................................................................................ptplalGu..h.stlatls.ts..ht..................................tht..ss........tph....p..p..Ch.....tspt..........................ppst.Nh.....h.+....l..l.........................h....s...p...........p...pL...............hs..CG...o.ss.ps.hCthh....phss..............................................h.p.h...........t.....p............p.spsts.s..h..sstts.t...s..ulhs.s.....................sp............................Las.u.s...shs.......................a.sps.........h...l..h........R.tht.......................p.t.s....h.c..t..........s.t...ph..l...p...........t.....P..p...Fl.....t....u.....h.........h...............shl..Y..Fh.a.p.ch..shphp............................tp..hh...hoR...lu.R...lC......p.....s..D.G...s..t.p.hl........phhs.....o......a.hcs.............cL.C.shss...............t.........has....L..pssh.h..h.s..tt...............................p.llaulF..o....s..s...s..s.h.s..........................SAl...Csash.p.....s..lppsF..p...u....htpp....p.ts.t........p..t.h...h...s..htt....t....hs......s...+......s.s....t.C..s.ts................................................................ph.s-phh..s...h.h.....c....p......p.s.......lh..........p....h........sl....t..t......p......Pl...hh.....p....p.....t...s..............................hTplsVs........t.s...t....s.......a....sVhFlG........T.....p..p..Gplh..hl..h............tt.............................hhtphthh....................t................................................................................................................................................	0	199	302	687
+4401	PF01118	Semialdhyde_dh		Semialdehyde dehydrogenase, NAD binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1079 (release 3.0)	Domain	This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.45	0.71	-3.81	188	10449	2012-10-10 17:06:42	2003-04-07 12:59:11	19	35	4748	117	2601	11025	5845	122.70	26	35.48	CHANGED	+VullGAoGhlGpcl.lclLpp..c...lchhhlhuspp..psGpphsthh.............htshhlps.......p.tth...ppsDllhhu..tssssupphssph..hptGh....hVID...ousaRhcs........................csshslPEl..N...tcplppt	...........................................plullGAoGhlGppl..l...p.h..Ltc......c......s.....l.....p.....h...h......h..h.....huosp.......ps..Gp..pl.s..h................................h..p..sh..s.lps.......hs...psh......pss.D..lsh..h....u....s..u....s...s...s....o..p......c....h.s...s..ph.............hp..s.Gs...........hVI...D...sou..s..a.R.hps.....................................................csshslPEl...N....ctlt.....................................................................................................................	0	809	1648	2203
+4402	PF02774	Semialdhyde_dhC		Semialdehyde dehydrogenase, dimerisation domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1079 (release 3.0)	Domain	This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase	20.90	20.90	20.90	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.50	0.71	-4.43	32	8792	2012-10-02 22:00:43	2003-04-07 12:59:11	13	14	4668	113	2044	6116	4228	174.30	26	50.65	CHANGED	LpPLhct..stl.ptlhVsohQulSGAGtp...........................................tssshshslshNllPalss..cct..poccchphhs-spphlshss..........u.CsRVPlhcGHopslphcht.....pshslccshphhtst.........stshlhs.....p.phPpsttsts...ssss.VGRlRpDshtsp...lthhsluDNlh+	................................................................LtPLhc..t....htl...p.p...l.sl.s.oh...pul..SGAGt..p.......................................................t..s..s.h.......h.......s.h........luhNll......Pah..ss.......h....cps..........ps.cc..E..h....+..h.h..s...-...s...p.....c...l...l.....s.ss........h................s.slplP....shcGHspslp.hc.ht......................psh.slpch...hph.h..tps.............................................tshlhsps...............ttthPpsh..tssG........ssts.lG.p.lR....p..D....t..s....sp......hlthhsluDNLhK............................................	0	662	1325	1741
+4403	PF03925	SeqA		SeqA protein	Bateman A	anon	COG3057	Family	The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [3]. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner [3]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [4].	22.70	22.70	23.00	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.24	0.71	-4.59	37	801	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	780	13	101	335	9	177.20	64	98.90	CHANGED	MKpIEVDEELY+YIASpTpcIGESASDILRRLLslssp......................pshshspPs.t..............................................................................s.spsttctVp.................slcpLlps-chsppctAVsRFlhlLssLYptsspsFspsh...plpGRsRlYFApscpsLLtuGss........oKPKpIPsoPFWVlTNsNTuRK+thLpplhtphthsspll-clpshl	.....................................................................................................................................................MKTIEVDDELYpYIASHTcHIGESASDILRRMLKFoAss..........................t.....usPsht........................................................................ps.t...h...sc.sps...spsl+D+VR........................AMRELLLSDEYAEQK+A...V.N..RFMLlLSTLYoLDspAFAEAT..ESLHGRTRVYFAuDEQTLLpNGNp........TKPKHVPGTPYWVITNTNTGRKpSMlEHIMQSMQFPAELIEKVCGTI..............................................................	1	13	36	70
+4404	PF04360	Serglycin		Serglycin 	Finn RD	anon	DOMO:DM07201;	Family	Serglycin is the most prevalent proteoglycan produced in haemopoietic cells. Serglycin is a proteinase resistant secretory granule  proteoglycan [1].	30.00	30.00	32.00	30.80	28.90	27.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.03	0.71	-4.48	3	52	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	31	0	21	58	0	122.00	45	76.59	CHANGED	QpLLpCoRLVLALAFILVauSSVQGYPsRRARYQWVRCsPDSNSANCIEEKGPtFDLLsGESN+IPPPRTDl.PlhpppsLN-lFPLSEDY..............................SGSG.GSGSGSGSGSGSGFLsEMEQEYQPVDENDAFYaNaRShDRNLPSpNQDLGQDGl	...................ss+lsLsLAllhhLtsus.pGhPsp..+ARYpWV+CsPDosSANCl-EKGPhF-L.PGEuN+I.s...hsD.hshpp...p..shschFP..l.SE..-h......oG..sS..G..SGS.GuuSGSG.....hsphc.-h....h-pps..a.s..s......................................................	0	1	2	5
+4405	PF00450	Peptidase_S10	serine_carbpept; 	Serine carboxypeptidase	Finn RD	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.43	0.70	-5.31	67	3902	2012-10-03 11:45:05	2003-04-07 12:59:11	17	45	756	20	2456	3840	269	353.80	21	80.72	CHANGED	PG.....ts...hsh...cpaoGYl.......sls.ttpsppLFYaFh....ESpp....sPppc.PllLWLNGGPGCSSls.Ghh.ElGPFpls......ss..sLhhNsYSWscsANllFLDpPsGsGFSYo..sssss.......hptsD....................ppsApDsatFLtpahpc.FPca....tsp..cFYIsGESYAGpYlPtluptIhptspt..............tlNL+GhhlGNuhs-s......hhphsshhs.....ahattullo.-ctacphpptCphs..............................stsp..tppChsthpphtt.................................slshYsIhpssh..............................................................shsshs.phspt..ahNptsVpcALph.....ss.hpWptCsp.tl........th..sch.pshhshhp...pllpss..l+lllauGDtDhhsshhuspthlcs....LshsstspapsWhh........................sspluGaspsY........ts..loFsoV+GAGHh..VPh.pPptuhthhppalsu	.....................................................................................................................................sGal...........................tht.........s....t...p...hF.aa.......hh..........................pu.pp...........ss.t.pp....Plhl.....Wl.............s.G...............G..........P.............G.s.SSh.......h..u......hh..E.h.G...Ph.thp..............................t........t..h......h........Ns..h.o.Ws...p..........h..............u............sl......lal..-p..............Ps....G.......s..........Ga......S..h..s...psstt...................s.p...............................................pt..s.....u.ps...hhthl...p..t........ah...pt....a...s.pa.....................t..s.......s....hals..G........E....SY.u......G.....hh..hPh..luthlhptt.t.................................hs.Lp..........G...h.h.l.s.........s...sh...h..s.....................p.h....thh.........................hhh........h....s.....h....l.....s........p......p...........h....p.....t...h....t...t.......h.......................................................................................s........t....h.t.h...............................................................t.............ths.hshh...............................................................................................................................................................t......h...........a.....h..s......p......t..l...p...p...s.lt.h......................tat.ss......l................................t..t..................s....h...h..........h...h..................tl..l...pt.t.........hpl.hl.h..........s.....G.p...............hD.h.h.s..............s..h...h......u...........s....phh.hpt.....................h.t.h....h...............a...................................................................tt....hG...h............................tt......hshh.l..h...........tuuH........hs.........t......s..s..hh..............................................................................................................................................................................................................................................................................	1	823	1473	2074
+4406	PF00079	Serpin	serpin; 	Serpin (serine protease inhibitor)	Eddy SR	anon	Overington and HMM_iterative_training	Domain	Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.	21.70	21.70	21.70	21.70	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.21	0.70	-5.32	180	5658	2009-01-15 18:05:59	2003-04-07 12:59:11	15	39	760	254	2183	5686	67	297.10	23	87.17	CHANGED	pusssFuhcLa+plspps.......ppNlhhSPhSl......psuLuhlhhGApG..pTtppl..tpsL...th....................................hstpp.......h.tt.........................hppl.hpplpp..............................tshplphANtla..h....p..cs.hplppsFhptscp...hYpup.hpslDFpsssp.utppINsWVpcpT...............pu+Ipcllsst.lss.s..TphlLlNAlYFKGpWpp..tFstppTppp.sFa..hsp.......spsh.pVsMM.ppp.....spaph......t.p....sspl..lcLPY........................ps.....sh.SMhllL..........P........su.lp..plc......ppLs.tt.....lpp.....hhpphp...hp......htl...tl..PKF..plpt....sh..cL.ppsL.pphG..lpchFs.spAD.hSsls...............................................................................s...t.LhlScllHKuhl-VsEcGoEAAAuT.........................................................Fpss+PFlFhIpcppo........................tslLFhG...+lhsP	.........................................................................................t.....hshph.hp..h..tt............ttN..hhhSP.h.ul........shu......hh......h.G...u.......p.......s.......p.......T...tt..p..h....p...s.l..th............................................................t.tp...h................................................h.t.pl..hptltt..................................................................tt.t..l.p.h..sst..l..a..h.............p......pt.....h.......t...h........t.p....ah..p...h...pp.........ha..t.............sp....htth.s.Ft.....pt.....t....s........t...p....tI...N..p.a.l..pp..p.T..........................p.s.p.....I..t....p....l....l..t.t.........l...s......t............s.......hh..h...ll.Ns..l...aF...+.........u.p...Wp..p......F...p.....p.........t..T.p.tt......Fh.......hsp.........tp...t......h...tV.hM...tp...........t.t.h..h.........................h..tt...t..h.....pl....lp.lPY....................................ps..ph..ohhl..lL.........................P.............pt....ps....lp....pl..................p.p..l.s....tt...............lt.p.....h..h.p.t.hp...p........ht.........l................hl..P..+F....pl....p..t....ph....s.......l...pphL..p.p....h.G......hp...p....hFs.....t..pus..hsths.......................................................................................................................................................................t....ttlhl..s..p..h..h...pp...s.h......l...p.............l..s.Ep..G..spu.s...u.so.................................................................................................h....h.s+P..Fhh.h..lh....p...p.......t............................lFhGph.................................................................................................	0	518	734	1365
+4407	PF02403	Seryl_tRNA_N		Seryl-tRNA synthetase N-terminal domain	Mian N, Bateman A	anon	Pfam-B_518 (release 5.4)	Domain	This domain is found associated with the Pfam tRNA synthetase class II domain (Pfam:PF00587) and represents the N-terminal domain of seryl-tRNA synthetase.	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.44	0.72	-4.03	89	5178	2012-10-01 23:07:44	2003-04-07 12:59:11	17	14	4789	32	1407	3708	1996	107.80	30	25.05	CHANGED	MLDl+hlRp....Ns-tlccpLppRt....ss.hsl-cllpLDcc+Rplhhcs-pLpscRNphS+pIuptcppt.....pcsstlhtcspplspclpsh-t.clpplcsclpphlhslPNlP	.........................MLD.l+.hlRp........s.-tVtcpLt..pR................stt..h..sl.-....clhpL.....Dp.cR...Rpl.....hs..csEpLpuc.RNphS...Kp....I...upt...Ktpt...................--spsl...htc..h....pp....lupclc..shcs.clsplpsclpplhhslPNlP...............................................................	0	483	906	1191
+4410	PF01445	SH		Viral small hydrophobic protein	Bateman A	anon	Prodom_1504 (release 99.1)	Family	The SH (small hydrophobic) protein is a membrane protein of uncertain function [1].	21.90	21.90	21.90	35.70	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.01	0.72	-4.31	12	328	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	18	0	0	315	0	56.10	83	99.85	CHANGED	MPAIQPPLYLTFLLLILLYLIITLYVWll.TITYKTAVRHAALYQRShFRWSFDHSL	MPAIQPPLYLTFLLLILLYLIITLYVWIlLTITYKTAVRHAALYQRSFFRWSFDHSL.	0	0	0	0
+4411	PF00017	SH2		SH2 domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.69	0.72	-4.17	58	9081	2012-10-01 22:44:06	2003-04-07 12:59:11	19	379	283	390	4864	8244	21	78.00	27	14.81	CHANGED	WaaGploR.....p-AEchLhp......tpsGsFLlRcScs.p.Gs...aoLSVppps.........pVcHa+Ipppsss........halssptp..FsoLt-LlpaY	..................................Waa.Gt.l..o..R...............pp..A.EplLtp.................t...sG.s...FL.lR......c..S...ps....p......G.s..........a..s.LS..lptps........................................plpH....h.pI.p..pp...sst................................hh.h......s.....t......t.....tp.......F..s..o..l..pLlpaa...............................................................	1	1219	1597	2956
+4412	PF00018	SH3_1	SH3;	SH3 domain	Cerutti L, Sonnhammer ELL, Eddy SR, Finn RD	anon	Prosite	Domain	SH3 (Src homology 3) domains are often indicative of a protein involved in  signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.20	0.72	-4.57	61	10749	2012-10-02 18:48:24	2003-04-07 12:59:11	23	695	444	373	5929	20245	89	47.10	29	7.39	CHANGED	hALYDapupp..ssELshpcG-hlpllpcsss...sWWcuc.ttt...sppGhlPu	.....................hAlYc..a..p.......u....pp.........ss.......E.......L..o.......hp...c..G..-hl.p..l........l......p...c.....s........ss..........sW.Wpu.ch...tt............sp....p....G.hhPs...................................	1	1639	2410	4041
+4413	PF04908	SH3BGR		SH3-binding, glutamic acid-rich protein	Mifsud W	anon	Pfam-B_6650 (release 7.6)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.23	0.72	-4.05	6	396	2012-10-03 14:45:55	2003-04-07 12:59:11	10	6	165	7	218	466	811	91.70	40	45.15	CHANGED	MVl+VYlASuSGshtIKK+QQ-VlthL-up+IpF-plDIot..cE-pRcaMRcNs....s..p+PssGtPLPPQIFN-DpYCGDYDuFhpApEpNTlhsFLtLs	...................slcVah.uos.oG..s..htIKK+QQcVhthL-A.p+I....pFc...plDIut..sE-pR.caMRcps.........pc..st.suhsLP....PQIFNp...-p....YCGDY-sFh-.ApE.pstl.tFLtL..................................	0	60	87	142
+4414	PF03579	SHP		Small hydrophobic protein	Bateman A	anon	Pfam-B_1121 (release 7.0)	Family	The small hydrophobic integral membrane protein, SH (previously designated 1A) is found to have a variety of glycosylated forms [1,2]. This protein is a component of the mature virion [1].   	21.20	21.20	21.20	107.20	19.50	21.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.11	0.72	-4.62	3	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	10	0	0	46	0	64.00	66	92.80	CHANGED	MsNTSITIEFTSKFWPYFTLlHMILTIISFLIIISIMIAILNKLCEaNsFHNKTLElspuhpNs	MsNTSITIEFTSKFWPYFTLIHMILTIISLLIIISIMIAILNKLCEaNsFHNKTLElspthpss.	1	0	0	0
+4415	PF01488	Shikimate_DH		Shikimate / quinate 5-dehydrogenase	Bashton M, Bateman A	anon	Pfam-B_336 (release 4.0)	Family	This family contains both shikimate and quinate dehydrogenases. Shikimate 5-dehydrogenase catalyses the conversion of  shikimate to 5-dehydroshikimate. This reaction is part of  the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. Quinate 5-dehydrogenase catalyses the conversion of  quinate to 5-dehydroquinate. This reaction is part of the quinate pathway where quinic acid is exploited as a source of carbon in prokaryotes and microbial eukaryotes. Both the shikimate and quinate pathways share two common pathway metabolites 3-dehydroquinate and dehydroshikimate.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.66	0.71	-4.06	44	8457	2012-10-10 17:06:42	2003-04-07 12:59:11	15	52	4195	91	2050	10811	5424	121.30	22	33.35	CHANGED	-LApphhs...tlp.sppsLllGAGchucLlsptLhsp.uscclhlsNRThc+AppLAcch.....ts....shsls-lp...phlspsDlll.ouTuupp.............llspphlcpsh...t.......h.lhlDIulPRslp.tlsthpsshlYslDDLctl	...............................................h.............tlp..sppsL.l.l..G.A...G...G...s.u...c...u.l.h.h...t..L...h...pt...G........s...p......p...l......h......l..s....N.......R......T.......h.......p.......+......A....p......p....L...A...pph.....................t..t......h....p......s....h....s....h....s.....c....lt...............th..h...t...p....h......D....ll...l...s.u...T....u..u.s.h.................................................h............h..............................................................................................h.........................................................................................................................................................	0	611	1298	1762
+4416	PF00464	SHMT		Serine hydroxymethyltransferase	Finn RD	anon	Prosite	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	399	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.06	0.70	-6.10	12	6460	2012-10-02 18:26:03	2003-04-07 12:59:11	14	19	4794	86	1789	5320	4336	351.50	52	88.05	CHANGED	Ls-tDPElashlcpEhpRQpcplELIASENasSpuVh-AhGSsLoNKYuEGYPGpRYYGGsEalDhlEsLs.cRAhchFsh-....hVNVQPhSGS.ANhuVYpALlpPtDplhGLsLscGGHLTHGh.ss.......oupaFcuh.YtVs.cTGhIDYDpLccpApha+PKlIVAGsSAYuRllDat+hREIADclGAYLhsDMAHIuGLVAAGVhPSPF.aAcVVTTTTHKoLRGPRGGhIhh+............-h..-ltcKINpAVFPGhQGGPh.HsIAAhAVAhKpAhpPEFKsYpppVlpNA+AhucsLpcpGYcLVSGGTDNHLlLVDL+s+GlsGscuEtsLtpssITsNKNolPsD.cSshlsSGlRlGTPAhToRGFsEt-FpcVutaI	..................................................................................................tphDs-lhph.l.p.p....E.ht.R.Q..p.pp...lELIASENa....sS......uVhpAtGS......hLTNKY......A.......E.G.....Y.P.......G..+.......R..........YYGGCEaVDhlE..pLAI..-R.AKcLF.....GA.....-.................................aANVQ...........P..H.S..GS.........Q......AN.......hAVYh.AL..L.pP.....G...D....ol............hG.....Ms.Lsp.GGHLTH...G.u.l......sh......................S..G+.h.a....p.......hlsY.Gl..c......c...o...t.hIDY.D..p..l..c...c...h..A..h..c......a.+.....P...K.l.I..l.A..G...h..S.A..Y..s...R...h...l.D...a.t...+...h...R....-...........I....A...............D...c.....V...G..A.......hLhVDMAHlAGLV......A.....A...G.....l..a.....P......s.....P.....l......P.....a.......A....c..l..VT.TTT..HKTLR......G..P.R..G..Gh.IL.sp............................................................................p-htKc..l..N..pAlFP.G.h..Q.....GG.P.L...H.V.I..AAKA.V.A.ht..E.A.h..pP-F.K.pYt.ppVlcNA+shA.....c................s......h......h......p......c.......G...h.cl......V....S...G....G....T......DN.H.Lh..Ll...D...L.p.......s......p.......s............l...o.G+..p.A-.th...Ls.ps..sI...TsNK..N.slPh..D...sc.s...P....h..l..T.S.........GlRlGTPAlToRGFtE..t-hcplAphI...........................................................................................................................................................	0	595	1137	1501
+4417	PF04917	Shufflon_N		Bacterial shufflon protein, N-terminal constant region	Mifsud W	anon	Pfam-B_6667 (release 7.6)	Family	This family represents the high-similarity N-terminal 'constant region' shared by shufflon proteins.	27.10	27.10	27.50	27.10	26.10	27.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.35	0.70	-5.36	3	374	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	230	0	47	352	5	249.60	32	68.40	CHANGED	MKKaD+GauuLEVGAuLLIVlllIuhuAchhpDYLpo+cWQssAcpsNsaToAVRSYVGKNYoTLLASSTTTTPAVITTsMLKNTGaLsSGFSETNS.GQpYQAhIVRNuQNsELLQAMVVSsGGpuhPhsALpQlAKDITsGLGGYIpDGKTAlGAhRSWSlsLSNYGssoGsGHIAVhLSTDDLSGAtEDoDRLYRFQVNGRPDLNKMHTAIDMGSNNLNNVGTVNAssushSGNVuGpNGTFSGulsGNou.....lTAGGDIRSNNGWLVTRNSKGWMNETHGGGaYMSDuSWLRSVNNKGIYTGGQVKGGTVRADGRLYTGEYLQLEKTAVAGASCSPNGLVGRDoTGAILSCQSG	......................................................................................................................................................................................................ttGh....h.p...h.h.....slhl..hhh.hh..hh..h.t...hts...ptht.p...A...pphs...pAsppYlt...cph.........s.sl......st.s.........................Ph.......h.......h......Th....t...Lhp..p..s.hL.suhptp..N...uQp..h.hh....l...h+..s....s...t.....s....st.....h...puhhh.o....p....G....Gp...s..h.............t....t.hh.h....ut.....hs..u.........GG....hl.......t........p.........s..........t..............u...........h..........G...shtuW...p........s.............ssa............u............t.s...........ss....G+lA.....hh.h....tt.............t..s-.......h....LYR..tVsu+P-.hN....tMps....slshssp...slpshtsh.s.st............t....h........................................................................................................................................................s...ts...s.....ssp......h.t.......s.....G..........p.l......pu......p......sph.stthl....pht.t..s..st.Cs..............sGhhu..hs..st.G...L................................................................................	0	12	27	33
+4418	PF02973	Sialidase	sialidase_N; 	Sialidase, N-terminal domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.21	0.71	-5.33	6	557	2012-10-02 19:29:29	2003-04-07 12:59:11	11	25	252	12	9	354	128	186.90	45	24.36	CHANGED	l.psh.hE..ssshsIusGpshcLsuEhs...lphL-pGTlllcFKuspps.ulQSLFSlSNupssN..caFplYlsNo.plGhELRsscuhhNYshups..sslhshhtsssshNTlAhKA-.psKpY+LalNGclltshspssspF..IssIsGlsslpLGuTsRtG.sptYsFsGsIsplplYNcsLoD-tLppcTGtTs	..............................................................................................l.pshphp..shphsh.Ssstt.scLSu..Elp....pphp..pu..TV..hMcFKsDsp.s......uh......s...LFulSsup..ttp.....pYFohhl..h..ss..phslEhRsusupt..Yh..ps....hpl..h..st.phspssh...ss.....t.su-....ctphpLYVNG..........lp.....h...s......S.p.s...s....sF..Ipc..hs...sls.+..s.plG.......A.........s...c.R....s....s...p....s.....ha..s..u....shpIcplolaN+ALos-EVpphot...................	0	5	5	6
+4419	PF03482	SIC	sic; 	sic protein	Bateman A, Howe K	anon	Pfam-B_5 (Release 7.0)	Family	Serotype M1 group A Streptococcus strains cause epidemic waves of human infections. This family includes the sic protein an extracellular  protein (streptococcal inhibitor of complement) that inhibits human complement [1].	19.90	19.90	20.60	20.20	19.60	19.00	hmmbuild  --amino -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.13	0.70	-4.78	8	450	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	7	0	4	450	0	193.50	81	91.33	CHANGED	ETYTSRNFDWSGD....DDWPEDDWSGDGLSKYDRSGVGLSQYGWSKYGWSSDKEEWPED.WPEDDWS..........SDKKDETEDKTRPPYGEALGTGYEKRDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWGGPGTVATDPYTPPYG.......................................................................................GALGTGYEKRD.............................DWRGPGHIPKPENEQSPNPSHIPEPPQIEWPQWN...GFDGLSSGPSDWGQSEDTPRFPSEPRVTEKPQHTPQKNPQESDFDRGFSAGLKAKNSGRGIDFEGFQYGGWSDEYKKGYMQAFGTPYTPSAT	................................................ETYTSRNFDWSG...............DDWP.....EDDWSuD........................YuW.....SSD..K........sEDDWS...........SDKKDETEDKTRPPYGEALGTGYEK.RDDWGGPGTV.ATDPYTPPYGGALGTGYEK.RDDWGGPGTVATDPYTPPYGGALGTGYEKRDDWRGPGHIPKPEN.E.QSPNPSHIPEPPQIEWPQWN......GFDGLS.GP.SDWGQSEDT.PRFPSEPRVsEK...P...QHTP...Q.....KNPQES....DFDRGFSAGLKAKNSGRGIDFEGFQYGGWSDEYKKGYMQAFGTPYTPSAT.............................	0	2	4	4
+4420	PF00158	Sigma54_activat	sigma54;	Sigma-54 interaction domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.98	0.71	-4.78	287	23376	2012-10-05 12:31:08	2003-04-07 12:59:11	21	270	3214	38	6053	30277	7477	165.30	44	32.07	CHANGED	llGpSsshpp.lhchlpplA...sos...ssVLlpGEoGTGKEllA+uI.....Hp.......tS.sR...p..st...PFlslNCA..Al..P-s...LlESELFGac+GAFTGAppp+t.GhFEtAsGGTLFLDEIG-hPlshQsKLLRVLQEtplpRlG.u.s.c.s.lplDVRlIAATNcsLpptlp.pGp..FRcDLYYRLNVlslp	......................................................................................lGpo.ss.hpp.lhct.l.p..p....l.A.......t..os.......ss.V.L.I.p.GEoGT.GKE....l....l...A.+.u.l.........Hp..............................tS..s..R.......t.......s....t.......PF.....l...s.....l......N.......C.....A......A..l..........P.c..s..........L........l.....E.........S......E......L.............F..........G..........a......p..........+...........G.........A......F.....T........G......A........p........p.........p.........+.........t.........G...h....F.....E...t.......A......c.......G.....G.....T....L.F.L.DE...IG-h.....P..h.p...........hQ....sK..LLR.V..L....p........-..t...p.....h.......p...R...l.....G...u...s.....p...s.....l...p..l..D.V..R...l.I.u.A......T.s..........c..s...L..p...p.......hl.p..pG.p..FR..cDLaYRLsVhsl....................................................................................	0	2150	3866	5098
+4421	PF00309	Sigma54_AID	sigma54_AID; 	Sigma-54 factor, Activator interacting domain (AID) 	Finn RD	anon	Prosite	Family	The sigma-54 holoenzyme is an enhancer dependent  form of the RNA polymerase.  The AID is necessary for activator interaction [1].  In addition, the AID also inhibits  transcription initiation in the sigma-54 holoenzyme prior to  interaction with the activator [1].	21.20	21.20	21.80	21.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.36	0.72	-4.49	153	2778	2009-01-15 18:05:59	2003-04-07 12:59:11	15	9	2568	0	623	2038	696	48.40	41	10.45	CHANGED	.pLphc.sQpLshTPQLpQuI+LLQhoshELpphlppplpcNPl..LEhpc	.............tLpl+.uQpLshTPQLpQuI+LLQLSslELppplpptl-pNPL..LE......................	0	216	410	521
+4422	PF04963	Sigma54_CBD	sigma54_CBD; 	Sigma-54 factor, core binding domain	Finn RD, Wigneshweraraj SR, Buck M	anon	Prosite	Domain	This domain makes a direct interaction with the core RNA polymerase, to form an enhancer dependent holoenzyme [1]. The centre of this domain contains a very weak similarity to a helix-turn-helix motif which may represent the other DNA binding domain.	21.10	21.10	21.90	21.50	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.23	0.71	-4.87	22	2858	2012-10-04 14:01:12	2003-04-07 12:59:11	8	8	2612	2	650	2119	1007	194.30	32	42.31	CHANGED	--Dt...hpshss.st.oLp-HLhpQlsls.hsss-RhIAhtLIDslD-sGYLp.hsLpElsppLs....sphscVcpVLphlQpF-PsGlhARsLpECLhLQL+phs.....h-.AhthlscpL-LLApRDassLt+hstlcE-DLt-hlp.IppLsP+PGspapssts-hllPDVhVRps.sGtWhVELNs-slPRlhlNppYh	.................................................s......htt..h.s...tpoLp-.aLh.Ql.p..l.t....h..o.cp..-.+t..IAphll-slD..-sGYLp.....h..............s........l-.-..l....h..c....phs..................................ls.h..--..l-..t.......l.L.c.hl.Q.p.h.DPsGVuA+sLpECLllQ...Lpphs..........................hhp...A..h.t.l.l...p.c.a...l-.hL....u...p.......+............ca....pp......L.h+.hh........p........l....p.p.c.p.l.....ccsl.s.l.I.p.s.LsP.+.P......G.t..p.h....t....s......s......c........s...p.......Y.......l.......l.PDlhVp..............c......p....s.......s.........c.....a..tVp..L.Nsc.shP+lplsppY............................................................................	0	226	431	549
+4423	PF04552	Sigma54_DBD	sigma54_DBD; 	Sigma-54, DNA binding domain	Finn RD	anon	Prosite	Domain	This DNA binding domain is based on peptide fragmentation data.  This domain is proximal to DNA in the promoter/holoenzyme complex.  Furthermore this region contains a putative helix-turn-helix motif.  At the C-terminus, there is a highly conserved region known as the RpoN box and is the signature of the sigma-54 proteins [1]. 	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.92	0.71	-4.72	29	2839	2012-10-04 14:01:12	2003-04-07 12:59:11	8	11	2603	3	645	2149	926	157.50	46	33.86	CHANGED	psalpcplppApWLl+uLcpRtcTlLKVuppIVcpQcsFLpcG.ptL+PLsL+clA-slshHESTVSRlTssKYltTPRGlaELKaFFouul.uossGu-.tSspAl+thI+pLlssEs..pcPLSDspIsphLccpG.lplARRTVAKYREuLsIPuSspR+R	..........................p.pal+pplp-A+WLl+uL.cpRpcTLL+VupsIVcpQps.FF..............pp.G..t.c.t..hKPh...sL+Dl....Aptl........sh........H.E..S........TISRsos...pKY.lpTP.+G.lF.ELKaFF....o..sp..l..........so...........p......s............G........u...-.......s.............S........osu.....I+s.hl+cLIss...E.s......p..K.P.LSDs.+lspl.Lp.-.pG..I.lARRTVAKYRE.pLsIPsSspRKp...............................	0	223	427	544
+4424	PF04546	Sigma70_ner	sigma70_ner; 	Sigma-70, non-essential region	Finn RD	anon	manual	Domain	The domain is found in the primary vegetative sigma factor.  The function of this domain is unclear and can be removed without loss of function.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.22	0.70	-4.71	124	3805	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	2580	2	391	2852	1705	206.60	36	49.01	CHANGED	aP.....sslshlLppa-+lpstEh..RLsDllsGalDP.......s..spss..t.hssc.spsptsc.................p-------p-.........................-s-sG.DPE.Atp+Fstlccpapphpp.......sl..pcpG+s..spp...stcthptluclFtth+LsPKpaDtLlpplRshh-pVRtpERtIhclsVcpu+MPRcsFl+tFs.GNETshsWlcphls..sp..csauptLpchps-IpcsQpKLhplE	................................................................................................................aPtslshlLppY-+.hp..s-ph..RLoDll...o......GalDPs.................................tttshAss.s..st..l.ss.chsc.s-hs-.....................................-------Dpss............................sps-s-su.DPclAtp+Fuplp....sQachs+c................ul....pc.p....GRs.......ccp........stttht.......pLu-lFpph+LsPKQFDtLVsphRshh-RlRsQERhIM+LCV-pu+MP+.c.sF.lptFs..u..........N........E..........sst.sWh-thht..ts...+sautt...ltchpp-lhcs.p+LttlE.............................................	0	87	203	293
+4425	PF03979	Sigma70_r1_1	sigma70_r1_1; 	Sigma-70 factor, region 1.1	Finn RD	anon	Prosite	Family	Region 1.1 modulates DNA binding by region 2 and 4 when sigma is unbound by the core RNA polymerase [1,2]. Region 1.1 is also involved in promoter binding [1]	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.71	0.72	-4.05	31	3466	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	3283	1	714	2077	1357	81.80	31	15.80	CHANGED	..chspspl.Kp.LIppGKccGa.lTYcElN-tLP.t-h..lss.EQl--lhphl.s-hGIpVl-.....-s-.....p.......tEp.t...sp-csst-Esp	..................h..t..pppl..+p.Llpp.G..K.c.p.G.a..LTYsEl....N-.pLs....sph.......lDu..-.........Q.lE-llphl..sDhG..IpVh-.......ps..s.-s.-.............sh........hhs-p..............tsDpss.....s...........................................	0	240	448	579
+4426	PF00140	Sigma70_r1_2	sigma70_r1_2; 	Sigma-70 factor, region 1.2	Sonnhammer ELL, Finn RD	anon	Finn RD 	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.97	0.72	-7.50	0.72	-4.27	183	8438	2009-01-15 18:05:59	2003-04-07 12:59:11	15	36	4678	31	1886	5884	3958	35.90	42	8.55	CHANGED	sDslchYL+EIGch.sLLos-EElcLA+clcpGtptt.c	.........tDsl+hYL+ElGpl.sL..LT.sE.-ElclA+RlcpG.......................	0	601	1232	1599
+4427	PF04539	Sigma70_r3	sigma70_r3; 	Sigma-70 region 3	Finn RD	anon	manual	Family	Region 3 forms a discrete compact three helical domain within the sigma-factor.  Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role.  Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme [1].	25.30	25.30	25.30	25.30	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.21	0.72	-4.09	82	10957	2012-10-04 14:01:12	2003-04-07 12:59:11	11	41	4723	32	2549	7548	3445	76.80	28	20.25	CHANGED	Epls+lp+sp+pLtQchGRpPoscElAcpLshs.ccVcchhphuppslSLchslupctDsphs-hlpDs.s.ssp-ts	......................................plN+lt+s.p...+p...L.h.......Q.........c...l........G..R..-...Po....s...-E...lA.....cch......s.....h.....s.-cV.....p..ch...L...c...h..u..p..c..s..h...S.l...-..s.....P.....l.......u......p...-....p...D...u.....p......l...s.......D......h...ltDpp...P.p..s..........................................	0	876	1740	2204
+4428	PF03084	Sigma_1_2		Reoviral Sigma1/Sigma2 family	Mifsud W	anon	Pfam-B_1759 (release 6.4)	Family	Reoviruses are double-stranded RNA viruses. They lack a membrane envelope and their capsid is organised in two concentric icosahedral layers: an inner core and an outer capsid layer. The sigma1 protein is found in the outer capsid, and the sigma2 protein is found in the core. There are four other kinds of protein (besides sigma2) in the core, termed lambda 1-3, mu2. Interactions between sigma2 and lambda 1 and lambda 3 are thought to initiate core formation, followed by mu2 and lambda2 [5]. Sigma1 is a trimeric protein, and is positioned at the 12 vertices of the icosahedral outer capsid layer. Its N-terminal fibrous tail, arranged as a triple coiled coil, anchors it in the virion, and a C-terminal globular head interacts with the cellular receptor [2].  These two parts form by separate trimerisation events. The N-terminal fibrous tail forms on the polysome, without the involvement of ATP or chaperones. The post- translational assembly of the C-terminal globular head involves the chaperone activity of Hsp90, which is associated with  phosphorylation of Hsp90 during the process [2]. Sigma1 protein acts as a cell attachment protein, and determines viral virulence, pathways of spread, and tropism. Junctional adhesion molecule has been identified as a receptor for sigma1 [1]. In type 3  reoviruses, a small region, predicted to form a beta sheet, in the N-terminal tail was found to bind target cell surface sialic acid (i.e. sialic acid acts as a co-receptor) and promote apoptosis [4]. The sigma1 protein also binds to the lambda2 core protein [3].	25.00	25.00	26.30	64.10	16.90	16.50	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.37	0.70	-5.84	4	120	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	42	18	0	98	0	322.90	50	99.77	CHANGED	MARAhasFhTshFGs.pslPhscpQlopLLpSSNSPWQct..shshslspuhloTsphPhsGShhYQcShLaSuhlPhlLhspDAW+-hpahchsWTsssLsGLVtAssP..AsP.YpPtuupaaDlppYPpWApchR.LpphYP.Lht.TLLNhhphGPlsYV-T.ssMlSGplsshhMohaG+sFtEIAhpLsQosuNhPhtsDusYDpthRhllSLahLSYlGVlpQssTIpGFaFpoKpRGsutEuWhL.Ys.TpupRlplspR+auahssRSPDWNhDhSalhuusLoAhlhSsRQ.PLluNpuVsNpupNhPGaoussGs.V+tlplhshAsEhIcphhhsGllossctpplptpusshpphhpscLssltspDDtL.ptpPphAR.RlKPFssssWssGpottulAuLAshh	.....................................................s.F.Gs.psl.shNcp..SpLLpuuNSPWQhh....h..hu.Glso.os.sPhsGSphYQ.ShLhSuTl.hshtspctWtshphhtLsWos.sLsGLVsA.s.s.AsP.....hQstusph.Dh.sYPpaApc.RthpphY..LhtsTLLshhthGPlhYVcs.ssMhSGtlsphhMs.hGpsFh-hshpLhQus.NhPhp.DusYsp.hphlhulahhShhGhlppptThtsFaFt.tp.u.t.-.hhL.hs.ststth..sttp......ahhstSPcWphs.shl.uu.Lot.lhus.p.t..P.h.hsptsl.s.upsh.sh.o...s.t..s...l..th..p.h.hstthh.phh.sGlhstupttthpt.hstht.hhpttltthhhtss.h.....t..th..hpPa.stpas..G.oh.s..............................................................	0	0	0	0
+4429	PF02454	Sigma_1s		Sigma 1s protein	Mian N, Bateman A	anon	Pfam-B_2133 (release 5.4)	Family	The reoviral gene S1 encodes for haemagglutinin (sigma 1 protein), an outer capsid protein and a major factor in determining virus-host cell interactions. Sigma 1s is one of two translation products of the S1 gene.	20.10	20.10	21.00	29.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.45	0.71	-4.32	5	20	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	8	0	0	20	1	114.30	61	84.05	CHANGED	CQ+uLNpGSRRSR+RsKYTLIhSoGSl+DSMpQpNESSLLSKVGpsWLHQhVppNLQSPDWKALSEPSKQLSMDLIRVLPsWVsEW-sLRQDLQsYAhTpsISL...REWlLRN....sTLDH	...CQKGLNQGSRRSR+RLKYTLIlSSGSsRDSMMQTNESSLLSKVGhsWLHQSVMhNLQSPDWKALSEPSKQLSMDLIRVLPSWVlEWDNLRQDLQSYALoTsISL...REWILpN....VTLDH......................	1	0	0	0
+4430	PF03842	Silic_transp		Silicon transporter	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	25.00	25.00	49.40	33.40	23.50	23.00	hmmbuild  -o /dev/null HMM SEED	513	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.80	0.70	-6.42	4	167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	79	0	7	165	0	287.70	62	98.66	CHANGED	hhoshssl+hhYShuLlIFSlIIVsALMFspsTKlApDspPhsALllMhhuIlWhSMlEGtQsShVGLPP.VD+sLYKESHPlTa+.suLuaKGDNLDRYLMGRQFMVlhlsFsINLCGuPL-su...-VLGLPpllppIFLsoGIAMILhsshIGQLTsQVNASHCMlDaINsaFhhFTLYssLlIEhoGVMHuSYLIQshhhhluGKPVpTNE.PRouhQshFFWGRVLhSLulLsFuLAVTlpALFsGpTTM...WphIPssVAllLFFlLMSlVGhLEGMQIAFFAVAKl.+pERGsp.Fu+KTCELLF+GpGcNLPGFMlGRQhTVshCFFllARVTTLDIEVGss-NIFGVSDGhQtFhNhGFhGAlITTILASIsWQLsASAFPlAFLsNPhsYIlLhluLhLEATGlCuGAWhLuhIpK+VstFphDEVYVGTPEE.RhutD+sDtphcts...tthhhGssh........................coasspppDhLc.........t.sup.cEttt..tu.s.cTcAL.chscpQ..-Ah-hhsups	......................................................................................................................................tst....-VLGhPshlp.lFLsh.GLuMIlFTChlGQLsoQVNAoHCMlDaINNYFALFTLYsAMslEFSGlMHuuYLIQ.lhutlSGKPI.SNE.P+sGhphhFFWuRVLMSlAILuFshAVslsALFsGpThh...asulsssluVhlFFhhMulVGhLEGMQIAFFAVAKLPtpERGouaFG+KTC-LLFcGNGpNLPGFMIGRQLTVVhSFFlVuulTuLsIpPGpGs.NIFGlSDGAQsFLNaGFpGAVITTILASIoWQLAASAFPlAFLNNPlTYlLLhlALhLEhTGlCuGAWV......................................................................................................................................................................................................	0	6	6	6
+4431	PF04801	Sin_N		Sin-like protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_6302 (release 7.5)	Family	Family of higher eukaryotic proteins.  SIN was identified as a protein that interacts specifically with SXL (sex lethal) in a yeast two-hybrid assay.\	  The interaction is mediated by one of the SXL RNA binding domains [1].	20.00	20.00	20.60	20.60	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.46	0.70	-5.62	15	414	2009-09-10 16:59:54	2003-04-07 12:59:11	8	6	306	0	263	406	1	288.50	21	70.12	CHANGED	EED....DPVVpEIsVaLupoLs-..pLYlhQYPl+stttsaDssp....................h.ss+lKPpspclEh-hulDTpSpsYDt.KuE...h.hsG........psupcpsshpsthh-tpsFhSs+shsssscYAVGlhpsGElHLTPLpuIlQhRPShpahD.K..p-pcpKs....cpsup--s-..scp............p..c.hptloV+FuR...tsp+t+ptR.pohphhpph.u-EsWlchpaashp.sspsphc+ptLhupsssss........sshshSsp-YlshLhssstccphs........ssspcsLspppL+shPLh-.Ql+sLhpcu+..VhpFuplhpLl.................spss.....s-plLcsLppsAhLVpGsWVsKS-llasc...u.......tshh.A-shppARDalLapFops.ct.lpRppls...ssspLssc-s.....+-lLsphAp..sp....ss+sWclhhssDc.-F.........p..cas-lVp+..QchhWpupppcLcchh	......................................................................................................................................--....Dslltphslals.............s.tt........plalh..Q...YP..+.st..............s....h..pt......................................................ps+hKsppt.h..l..E.l-hsl.sp....s...t....as...hs..................................................................t.tpt..t.h.ppt.....hh............t.tts......s...s.tYh...h..uh.h......p......p....t...........p....l..HLsPl.p.ulhQhRPphpalD..t........ptp..tpt............ptt.tptttp..tpp.............................................t.hp.lp....h.p..ht.......p.......stpt.....t......t..t.t.....s...h..p..h.tp..E.Whphpaht.p..s...s......................hh............................................................h.......................................................................................................................................................................................................................................................................................................................................................................................................................................h..........................................................................................................	0	94	148	217
+4432	PF04954	SIP		Siderophore-interacting protein	Bateman A	anon	COG2375	Family	\N	26.30	26.30	26.60	27.10	24.30	25.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.58	0.71	-3.73	169	1985	2009-01-15 18:05:59	2003-04-07 12:59:11	8	15	1328	1	509	1471	82	120.80	30	41.36	CHANGED	schhLLsGD-TALPAlushLEpL...P.sssputshlEVssss-.p.slss........ssslplpWlhRsss............tsshLhp.slpshsh....................................................................ss......ssasW.lAuEusss.+slRcaLhp-tGls+p.plthsuYW+pG	..............................................................................................................................h...hLhluD-oulPAlsphL...EsL..............P.ss.spsp.sl.l.c.V.ss.ssc....p.....Lsp...................hssh.plpWlh+ssp.............tslss.slpp.hph...............................................................................s......................ss........shasW.lsGEupsl.+slR+hlptEhulspp.plpssuYW+t.................................................	0	125	323	436
+4433	PF02146	SIR2		Sir2 family	Mian N, Bateman A	anon	IPR003000	Family	This region is characteristic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organisation and DNA damage repair processes [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.21	0.71	-4.54	20	5869	2012-10-03 09:55:27	2003-04-07 12:59:11	12	37	3562	114	2282	5061	910	172.30	31	58.89	CHANGED	GAGISspuGIPDFRS.csGLas+hspcs..LssPpshhchsphhps...FYsht+chh....pspPsssHphlstLEcps.plhplhTQNIDsLcccAGsp..pllEhHGShspspCssCch.hstpplhpphchtp.s..............................pCspCGu...................................llKPDlVaFGEsLP.cphppshc.clpcsDlllVlGTSLpVhP	.......................................................................................................GAGlSs.p.....S..G..I.............P....sF.R......u...........t...s..G.......l.a........p........p........h........p...........t.................l.............s..s.c.......t.....h...h........p.......p...s...h...h.htp....................F..a.p.h.h.c........phh...............pspP......N.h..u...H.hhl..............A....p....L.............p.........c.........t.........t..............h........h.t....l..........lT.Q...........NlD......s.............L........H.......p.............c........A............G..sp.....................pll...ch.HGslhp..s.p....C.....h.....p....C.t......t...........h........s....h.....p.........h..........t...p....h....t...t..t....t...s......................................................................................pC...s...p...C..s.u.....................................................................................................h..l+P.c.l..V........h..F......G.....E...........ls........t....h...p...p......s......h.............p...t............h.........p..........p...u.............D.........lh.lllG.TShtVhP.............................................................................................................	0	811	1362	1902
+4434	PF04247	SirB		Invasion gene expression up-regulator, SirB	Mifsud W	anon	COG3094	Family	SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown [1].	29.70	29.70	29.70	29.90	26.90	29.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.48	0.71	-4.39	63	976	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	953	0	140	446	33	123.40	43	97.35	CHANGED	h.YhslK+lHlshlslSlsLFllRhhhhhpsus.hhpp+h.....l+IsPHllDTlLLlSGlsLhhlh...phhPFss..sWLotKlhullsYIsLGhhAL..+ps+.....spth+hhA.FlsAlsshhhlstlAhoKt..sh..l	......a.hLhplHLlsluLSlsLhslRaahphppps.....ht.h.....t+a.....s+IlP......llDTlLLLSGIuLhhhs...phhPFostutWLTEKLhuVllYIlLGalAL..+pt+.....o...p..p..sRhhA.F.LA.LlsLhhIlKLAsTKhPlL.....................	0	28	71	108
+4435	PF01380	SIS		SIS domain	Bateman A	anon	Bateman A	Family	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.  Presumably the SIS domains bind to the end-product of the pathway.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.28	0.71	-4.54	45	30074	2012-10-02 15:05:26	2003-04-07 12:59:11	17	45	4875	210	6102	21679	8959	126.50	18	45.69	CHANGED	hltpsc.plhlhGtGsuht.suhththph.pplshhsshst.usp.....httt.hshlspsclllhlo..hsspstchhpsst.hsppps.sph..lsITspssusluppu...chhlhh.ss.ph.......hpshssphsshtslhht	..........................................................................h...ptp.plhhh.G.tG.s....o....hh...s....u.h....p....h....t..h....pl...p.......p...h.......u...h...h..s...s.....t....s..h...s..u....st....................h.tts......h....s.....h.....l...s......p....s.......s....l....l....l.s.lS.......tSG........p.....o........t........-........h.....lt.....s.....h.......p...h....s..+....p.......p........G....spl............lsl....o...s.......t...s...s..o....s.....l..s.....p.....u.........s..h...s.l...h..h....s.s..ch...........h.s.h..t..s..h.ss.phhhh.hh...h.................................................................	1	1857	3650	4961
+4436	PF05185	PRMT5	Skb1; 	PRMT5 arginine-N-methyltransferase	Wood V, Mistry J	anon	Pfam-B_4050 (release 7.7)	Family	The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase [3][4].  These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.61	0.70	-5.57	35	750	2012-10-10 17:06:42	2003-04-07 12:59:11	11	21	319	29	484	1612	79	345.80	25	63.15	CHANGED	-.hssWphWsslRphC.sap.spLpVuLcls..psl.Pst....p.lpRWhuEPlcslllssshFlsN..pp.GaPsLsKtpQplltpahphpssthlls........................................................t.sscpshss...Ylp....Yl+aLhpp........s......shsttcpht..sYpDhLQsPLQPLpDNL-StTYElFE+DslKYp.Y-cAIppALhDhssppctss.........................hllhVlGAGRGPLVcpsLpAuppss..s........plclaAlEKNPsAhlhLp.p+.phcp...W...ts+.VpllpsDMRpapsst.......................KsDllVSELLGSFGDNELSPECLDGhQ+.....aLpps.GISIPpuYoSY...................lsPIsuspLasc...........lpthpp................................ssshEpPYVVphpshthlusp.............................ppsapFpHPstp...............................p..tcNsRapslpFps.pp...cuhlH..........................GFuGYF-usLYpD........lpLSIpPs..........................................s...+oss.MhSWFPlaFPLcpPlhlpcss.........plplphWRpss..spKVWYEWslss	......................................................................................................................................................................................t............................................................................................................................................................................................................................................................................................................................................................................................................................................hllhslGuGpG.Ls.h.uhpAu...........................thcl.Y.AV.E.t...s...s.....A...h.t.h.p.th...p...t.p.t.....h.............ssp...l.pl.....l...p...u...ch.cch....p...h.P.-...................................................................psDlllSEh.h..G..s..h.h....N..E..h...s.E.....s....l.....ut.....p.+...........aL.+ss...G....l....hPsp..hsha.....................luP.h.s.s..t..p....l..a.p.c....................hh.s.h.tt...................................................t.hcps.h...l.....s....p....hp.sh....h.....l.uts..................................................p..s.h.s.F.p..cspts....................................................................tp..p.p.h..pt....t..h.p.F..t....h...pp.........su.hlH................................GhusaF-...s....h...h...h.t.s............................lh..L.S.h..t.Pp.................................................................p........shhpWh...hhh.l....p..pP.l...lptsp............pl..p..h.....h................................s............................................................................................................................................	0	182	271	391
+4437	PF01202	SKI		Shikimate kinase	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.08	0.71	-4.36	98	7157	2012-10-05 12:31:08	2003-04-07 12:59:11	17	51	4272	70	1785	5455	2766	155.30	27	64.96	CHANGED	hGuGKoTlG+hLActLshpFlDs.Dp.h..I....EppsG....hslspIFp.pc.GEssFRchEpcs...l..pclhppp.....shVluTGGG..slhppc...spphLp.............ppGh.llaLcssh-tlhpRl..p.pcpp....R...PlL.psps.........p.h....h..chlh.pRpslYpc..h.....u......s.h..h.hss.spps..............pplsppllptlp	...............................GuGKoTlGp.t.L.....Ap..p.L........s.....h.p.........Fl....D..........s...D.p..h.........l.............p.pps.s.......tsl...u..p..l..h.s...h.p....G...E...s...s....F......R......p...h.E..p.....p....s........l........p.c....l....t..pp....................ssVl..u....s.......G..G...G......s..........s...hp.cp..........sR.s..hLc.......................................tp..sh....s..l.a...L..c..s.s..h...-..h..lh.pRl....p..tcps............R......Phh...psps...........................ph......h...chlt.....p.Rp..s.h.Ycc....h.....s..........t.h..h..l.ss...spts.............ptlspplht...t.................................................................................................................................................	1	506	1065	1476
+4438	PF02731	SKIP_SNW		SKIP/SNW domain	LOAD	anon	LOAD	Family	This domain is found in chromatin proteins.	25.00	25.00	30.50	30.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.14	0.71	-4.77	28	359	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	296	0	242	348	3	154.70	53	31.04	CHANGED	spaI+YTsssp.ss.t........pp......RII+hsppp.....pDPL-P..P+F.K.+K+lspsssSPPsPlL+......SP......sRKLTtEDppcWcIPPslSNWKNsKGYTIsLDKRluADGRu..Lpcsp.....lN.-+FApLo-AL.hA-+pAREElctRschp+phs.+EppcKE-+LRpLAp+ARp-R	.......................................s.palR.YTPupQs.sshsp.........tpp........RlI+hVEhQ.....pDPhEP..P+F.K...pKKlPR.G..PPS......P..Ps....PVhH..........SP..sRKl.Tsc-Qpc....WKIPPsISNWKNsKGYTIPLDKRLAADGRG..LQsVp................IN.-pFAcLuEALahADR+AREtVchRAphp++hApKEKppKE-cLRplAQ+ARpcR...................................	0	80	132	199
+4439	PF03217	SLAP		Bacterial surface layer protein	Mifsud W	anon	Pfam-B_2530 (release 6.5)	Family	\N	27.00	15.20	27.10	15.20	26.80	15.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-11.08	0.71	-3.93	27	528	2009-09-14 12:59:11	2003-04-07 12:59:11	9	28	47	0	108	469	0	105.10	28	27.52	CHANGED	oK......slMHsAYsYs.psG.c...+l...ss...h.hpshs....sls...h.hs........s..sts..I.sGKpYY......+Vup.s.....cYItAuNlDGTpRh...LK+NAYVYss.supR....ssph.hh+KGoplsTYGushplhNGK.pYY+IGt..s..tpYVKsuNF	......................................................................lh+suhhYs.psG.p...ph......st.........h...hhthp....plp....h..h................s..hhp.....I...sup...pa..Y......plsps......pYl.....pus.N..l...s...u...s.p+p...................lp+.NAYlYppss.p+...............ttp....h....hlpK..Gpplp..s..a..Gs..p.h...h...t..Gc.pY.Yplst....s.....pal+s.s..............................................	0	10	10	24
+4440	PF03843	Slp		Outer membrane lipoprotein Slp family	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.60	20.60	21.00	34.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.70	0.71	-5.24	38	1178	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	813	0	129	486	27	159.70	46	83.93	CHANGED	LuGCso.lPptl..tspsssh.shsplpssssshhGppVRaGGhIlslcN.ppspTplEllshPLss.su+P.phs..ppopGRFlAphsGFLDPssatpGRhlTllGslpGhcpsplGchsYpaPVlpspsh+lWp....htpph.hss.......a...s.ah..ashh.....hWt	..............................LuuCso..lP..psI.t.s.ssP.ss.QpshVtVhstPtLYl..........GQpARFGGKV..lsVpN.tpscTcLEIAslPLDS..uA+P.sls..ps..spGRlh.AchsGF.LDPVsa.RGphVTVlGsIsGs...s.GK.IGpsPY.pFhlhps...pGa+hWH......Lppp.V.hssp..........sa..h.Y...G..u.....h.........GaG....u....Y................................	0	32	65	98
+4441	PF01464	SLT		Transglycosylase SLT domain	Bateman A	anon	Prodom_3175 (release 99.1)	Family	This family is distantly related to Pfam:PF00062. Members are found in phages, type II, type III and type IV secretion systems (reviewed in [4]).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.54	0.71	-4.61	39	14235	2012-10-03 00:09:25	2003-04-07 12:59:11	15	167	3793	20	3295	11652	3304	115.80	22	28.70	CHANGED	shhttstpphslpstllhAlstpESsasPpAhS......tss.......................uhGLMQlhssTspthth...........shsphhcPppslpsGspaLp....phhpphst.......shhhuluAYNuGhuphtchhptttptstphhh	.............................................................h......ttthtl.s...t.h...lh.ul.h.htE...S....s......a......s.........s...p...A....h......S................sss........................................................................................AhG..LMQ.....l..h...s...s.T..u..p.p..hs.......................................sh.s...ph.h.-P.t...p....s..l.ps....G.s...p.....Y...Lp..........th..h..p..p..hst.......................shhhs.luA.Y.N..u.G....u...p..h.phht...........h....................................................................	1	900	1993	2657
+4442	PF02258	SLT_beta		Shiga-like toxin beta subunit	Bateman A, Mian N	anon	Pfam-B_3684 (release 5.2)	Domain	This family represents the B subunit of shiga-like toxin (SLT or verotoxin) produced by some strains of E.coli associated with hemorrhagic colitis and hemolytic uremic syndrome. SLT's are  composed of one enzymatic A subunit and five cell binding B subunits.	21.10	21.10	21.20	21.50	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.44	0.72	-4.14	2	261	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	133	146	1	142	0	67.60	81	78.02	CHANGED	As.DCspGKlEaoKYN-DDTFTVKVssKEhaTsRWNLQsLL.SAQlTGMTVTIKossCcsGuGFuEV.Fp	...................M.AADCAKGKIEFSKYNEDDTFT...VKVs..GKEY.WTSRWNLQPLLQSAQLTGMTVTIKSSTC-SGS.GFAEVQFN....	0	0	0	0
+4443	PF04102	SlyX		SlyX	Bateman A	anon	COG2900	Family	The SlyX protein has no known function.  It is short less than 80 amino acids and is found close to the slyD gene. The SlyX protein has a conserved PPH(Y/W) motif at its C-terminus. The protein may be a coiled-coil structure.	30.00	30.00	30.00	30.20	29.60	28.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.43	0.72	-3.60	114	1397	2009-09-11 12:49:59	2003-04-07 12:59:11	7	3	1387	1	285	730	213	67.60	42	92.66	CHANGED	plppRls-LEh+luFQEcsl-pLNpslscQppplccLpcplphLtp+lcshp.sst...ustsc-...sPPPHY	............hEtRlsELEs+lAFQE.TIEELNtslstpphphs+LpcpL+hLscKlcs...t....p...sSsh......As.pu-E..........TPPPHY..............	0	67	152	221
+4445	PF02481	DNA_processg_A	SMF; 	DNA recombination-mediator protein A	Mian N, Bateman A	anon	Pfam-B_2252 (release 5.4)	Family	The SMF family, of DNA processing chain A, dprA, are a group of bacterial proteins. In H. pylori, dprA is required for natural chromosomal and plasmid transformation [1]. It has now been shown that DprA is found to bind cooperatively to single-stranded DNA (ssDNA) and to interact with RecA. In the process, DprA-RecA-ssDNA filaments are produced and these filaments catalyse the homology-dependent formation of joint molecules. While the E.coli SSB protein limits access of RecA to ssDNA, DprA alleviates this barrier. It is proposed that DprA is a new member of the recombination-mediator protein family, dedicated to natural bacterial transformation [2].	29.60	29.60	29.70	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.27	0.70	-5.44	97	4687	2012-10-01 21:16:48	2003-04-07 12:59:11	10	17	4194	1	1010	3571	633	204.40	38	60.24	CHANGED	t.hppts...h.phls.ht-spYPptLcp.l................c...sP.hlLah+G..........shshL....t...slAlVGoRpsoshGtphspplsppLup.t.....uh..slVSGlAhGIDstAHpuAL.....ptt........GtTlAVLusGl..-hh....YPppNppLhpcIhp..p.GhllSE.....assssp.PpptpFspRNRIIuGLopullVlEAsh+SGoLlTAchAhc.u....RcVaA.l....PGsltsspupGsppL....IppG.Atllps	......................................................................................h...t.th.phls.ht-ttYP..h.Lpp...l...............................h...........s.sP.hlLahcG.........................shphLp.............p.plAlVGoRp..s...........ot....hG.p..........phsp.....pls.pp...Lup..p.......uh..s.llS.GLAhG..IDssAHpuAL......p.s.t..................GtTl.A.V.l.usGl..-..t.h....YP..pp.pppLtppIh.....ptGh..llS....E........a..s..s.....s.s..........Ph...t...hp..FPpRN....RIIuGLS.p.u.ll...Vl....EA...........s.......h....+.S...G.SL..ITA.chAh.EpG.......R.-VaA.l......PGsl.ts.s...hSpGsppLIcpG..Apllp.s................................................................	0	340	676	868
+4446	PF03467	Smg4_UPF3		Smg-4/UPF3 family	Bateman A	anon	Bateman A	Family	This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4 [1] and UPF3.	21.30	21.30	22.10	21.60	19.50	20.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.37	0.71	-4.27	6	408	2012-10-02 20:46:34	2003-04-07 12:59:11	10	11	263	3	260	394	1	159.80	33	36.82	CHANGED	ppsppctp.KVVlR+LPPsLTcc-hhpplps.Ls-c..................WshFchhsushSacsptYSpshlpFps.sD.lhEFpshFsGal....FlDsK......ssphhAlVEhAPa.QKlspssK..hKcDs+pGoI-pD...PcahcFhcplt..ctpsspsh..s-p.lc+.........tcstppht+h.sTPLl...-Yl+pK+sp+	......................................p......h...KlVlRRLPPsLTcpph.p.tl..t...s.......ls.tc......................................................p.ha...p.h.....hs.......s.ph...sh.h..........s.p..h.a..........S..............R...AYl.s..Fp..s...-.D...lh.Fpc..pacGal...................F.lDs+...............................G..p..h....sh......VEaAPa..Q+...h....sp...pp.............p+cD..s+.....tGTI...-pD...s-YhpFLEs..h....t.........p...p.p.....hts.......ct.lpc..........................pt.....ps.t.....p..h.....thh..sTPLl......pal+.p+ph........................................................................................	0	76	129	202
+4447	PF04927	SMP		Seed maturation protein	Kerrison ND	anon	Pfam-B_6221 (release 7.6)	Family	Plant seed maturation protein.	21.00	21.00	21.00	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.04	0.72	-4.01	37	316	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	61	0	192	289	0	59.60	34	56.79	CHANGED	tlplG-sL..........pAsuttsucKP...VstpDAAulpuAEs+ssGt...............tshPGGlAA..shpuAAshNtpsst	.................lphu-sh............p.sut....suc+P............lstpDAutlp.uAEs+spGt.................psts..GGl..AA..shpuAAshNtph..t...........	0	25	103	158
+4449	PF04355	SmpA_OmlA		SmpA / OmlA family	Kerrison ND	anon	COG2913	Family	Lipoprotein Bacterial outer membrane lipoprotein, possibly involved in in maintaining the structural integrity of the cell envelope [1].  Lipid attachment site  is a conserved N terminal cysteine residue.  Sometimes found adjacent to  the OmpA domain (Pfam:PF00691).	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.36	0.72	-4.36	146	2731	2012-10-01 23:09:26	2003-04-07 12:59:11	8	6	1710	10	507	1486	1060	70.60	29	49.17	CHANGED	GshlspptlsplpsG.Mo+pQVphlLGoPhhs.ssFsss.pW..Ylhphpps.....t.tt..........p..ppplslhF-ssshlpths	..........Gphlstsslppl+.......hG.Mo+pQVthlLG.sP...hhp...s......h...p...sp.....sW..Y..lhpppsu.....p.t...........................p...ppsltltFsssGhlps..s...........................................	0	102	248	380
+4450	PF01668	SmpB		SmpB protein	Bateman A	anon	Pfam-B_1766 (release 4.1)	Family	\N	20.20	20.20	23.20	25.90	19.70	18.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.11	0.72	-4.17	166	4544	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	4483	12	970	2590	1894	67.80	47	43.63	CHANGED	ph..l..ApN+KA+a-YtI.-paEAGlsLpGoEVKSlRs.G+sslp-uastl.csG....EhaLhssaIssY.ppush.h	............hl.ApNKKARH-YhI...-.paE..AGlsLpGoEVKSlRs...G+ssLpDuaspl..+s.G....Es..aLhssHIsPYppush.h........	0	339	651	828
+4451	PF01713	Smr		Smr domain	Bateman A	anon	[1]	Family	This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 Swiss:P23909 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2 Swiss:P94545 [1]. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity [2]. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.89	0.72	-3.79	123	5312	2009-11-23 09:46:11	2003-04-07 12:59:11	16	56	3968	8	1427	3901	1760	78.00	31	16.90	CHANGED	lDLHGhphc..-Ahptlpphlppshppsh...................pslh.lIpG+G......................sG.h......L+ptltpaL....hphphl.tht.s....t.G.usGshhVhl+	........................lDL+Gh.ph-..-Ah....p....tLt.p.a.lspuh.t.psh................................................................pplp.llHG+G........................su..h..........L+ptVt.paL.....tppppVhuap.A....ptG.GsGuhlVhl...........................	0	513	907	1211
+4452	PF00835	SNAP-25		SNAP-25 family	Bateman A	anon	Pfam-B_1606 (release 2.1)	Family	SNAP-25 (synaptosome-associated protein 25 kDa) proteins are components of SNARE complexes. Members of this family contain a cluster of cysteine residues that can be palmitoylated for membrane attachment [2].	21.20	21.20	21.50	21.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.32	0.72	-3.19	13	273	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	105	20	132	235	0	55.90	41	26.35	CHANGED	PhNK....hps.c.ttstppsW+sNsD......GtVlssQP.tRVhD.tpssh.....sspuGYI..pRI.TNDA	..................PCN+....h+s.c...uacpsWusNpD.........GtVVus..Q....P...u.R.Vsc.pppph........usSGGaI..pRl.TNDA..........	0	27	39	81
+4453	PF00565	SNase		Staphylococcal nuclease homologue	SMART	anon	Alignment kindly provided by SMART	Domain	Present in all three domains of cellular life. Four copies in the transcriptional coactivator p100: these, however, appear to lack the active site residues of Staphylococcal nuclease. Positions 14 (Asp-21), 34 (Arg-35), 39 (Asp-40), 42 (Glu-43) and 110 (Arg-87) [SNase numbering in parentheses] are thought to be involved in substrate-binding and catalysis.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.32	0.72	-3.79	18	4232	2009-01-15 18:05:59	2003-04-07 12:59:11	12	46	2100	210	1727	3872	2427	105.40	24	47.39	CHANGED	+lRLsulDsPEosc..t..................psaGpcApcah+chlhtpclhlh.hsp.....D+YGRhLuhVahs.........spslNttLl+pGhAhsht.hYss..p.tppsphhpsEpcA+cc+hGlWup	........................................................................lRLhsl-..s..P...E...ht.............................................................ps.a....G..pc......A..p...p.h..h.c...ph...l..h....s.....c...p..l......p...h.t.h..sp..................D..c......a......G.....R.h...l.....uh.l.a.hs..........................................sps..l..sptl..VcpG..h.......Ahs........hp....h..............h......s..................................t......h......................p..........t.......h..h..pspppA+p.p.+hGlWp..................................................	0	583	1042	1458
+4454	PF00209	SNF		Sodium:neurotransmitter symporter family	Finn RD	anon	Prosite	Family	\N	19.70	19.70	19.70	19.70	19.40	19.50	hmmbuild  -o /dev/null HMM SEED	523	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.89	0.70	-6.03	15	11073	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	2324	84	3409	8360	1447	275.40	18	89.59	CHANGED	R-sWssKh-FlLSslGauVGLGNVWRFPYLCYKNGGGAFLIPYhlhLlhsGIPLFFLEluLGQasppGulslWt+ICPlFcGlGYAshlIshalslYYsVIlAWAlaYLasSFTssLPWspC......spsWNTscCh-.h..psts.............t..sho......t.SPstEFWcRpVLplo..........sGIpchGsl+WpLsLCLlluWlllYFslWKGVKooGKVVYFTATFPYllLhlLLlRGlTLPGAhcGIpaYLpPcap+Lt-PpVWlDAATQIFFSLGlGhGsLlAhuSYNKacNNCYRDullluhlNusTSFlAGFVIFSlLGFMApcpGls...........................................Iu-VAcs.....................GPGLAFIAYPcAlThhPhSPhWulLFFhMLlhLGLDSpFsslEullTullDpaPhhh+...+RElhshhlslhsaLlGLhhl.TcGGhYlhpLFDpYuAo.hsLLhlshhEsluluWlYGss+Fhc-Ip-MlGaRPshaa+hCWpFloPslhlslhlhSllpa..pPLsYss.Ys..........YPsW.u.ulGWhhALSShlslPlahlh+lhpt	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hh...................................................................................................................................................	2	1079	1659	2764
+4455	PF00176	SNF2_N		SNF2 family N-terminal domain	Sonnhammer ELL	anon	Published_alignment	Family	This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null --hand HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.00	0.70	-5.62	28	15349	2012-10-05 12:31:08	2003-04-07 12:59:11	18	509	4016	6	7427	19108	4238	288.60	21	25.86	CHANGED	aQhcGlpWhhphh................................................................................................................psthuGILADEMGLGK..............TlQsIullt......................hLtcttphh..................tP...................................................................................................................................................................................................................................................................................................tLllsPt.ShlpsWhsEhp+as.s.sl..pslsatGsp................................................................p.hhphtphhtshsVllToY-hlh......................+phshlpp..hc..WphlllDEuHpl...K........NspSpltpslpp.lp..sppRllLTGTPlQN....sLtElauLlsFlhPshas.........shc..sFcphh.....tts....................ptptspcthppLppllps......................hlLRRhK..s-l..pcs.....LPsKpcpllhsphoshQpchYp............phhppschhhstss................................................thpphhshlhpL+KhsNHPhLh	..................................................................................................................................................................................................................................................................................................................................................aQ..uh.t.ah................................................................................................................................................................................................................................................................t......th.s.s.lL....A..D..-......M....G.........LGK.............................T....l..p....s..l..s..h.lt...................................h.h.p..t...t..t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hLl.l..s......Pt.....o...............l....l....t....p....W....t....p...........E....h...p....c....a...h....................p.l.............ph.h....h...h....p....u....sp..........................................................................................................................................................................t..........t...............t...........h.......t.......p.........h......s.......l....l.....l...s...o....Y.phht...............................................................................................................................p....p....h.....p...h....ltp............hp..........a..p...h..l....l..l...D...E........u.Hp.l..........K.....................................N...t..p....o....p......h......h...p.....s..l.....p....p...lp..................spp...+.......l.......h.....L.................T..........G.....T...P..l....p...N.............................sl.t..E..L..a.....u...l..h....p....a.....l..........P..s..h..hs................................................shp.....pF...p.p..h.h.................................................................................................t.......t....t...h...p...p...L....p....p.....h...l...p...s.........................................................................................h.h..l..R..R..h.+..........ppl...........p..............................L..P.........+...............................p...................h......h..h....h..t...h....s..t..............p...p......t....h...Yp.................................................................th.h.t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2588	4337	6155
+4456	PF04855	SNF5		SNF5 / SMARCB1 / INI1	Kerrison ND	anon	Pfam-B_6054 (release 7.6)	Family	SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes  characterised so far [1].  This family consists of the conserved region of SNF5, including a direct repeat motif.  SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF  complex [2]. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs) [3].	21.80	21.80	22.00	21.90	20.30	20.80	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.66	0.70	-4.91	25	526	2009-01-15 18:05:59	2003-04-07 12:59:11	7	15	262	0	346	474	0	197.40	33	41.27	CHANGED	ppApp..........tsLVPIRLDl-h.................................-th+LRDTFhWNlsEplloP-tFAphlscDLclPsss...hhppIussIppQlc-Yts.........................................s.ht.p.....................................................................................-hRllIcLsIslupppLhDpFEWDlss.sssoPE-FApphssDLGLuGEFssAIAHuI+EQl.hhpKplh......................Gashsupslt-s-hctth.hss..................hsshhp.spptscpasPhlppLocsElE+pEt-+-Rph....R	.................................................................................................................t..sp..c.LVPIRLDh-h.......................................ss..+lRDsFh..WNhp........-.......ph.hos-.....FAph..hscDLc...L.......ss...............hhstIsptIcpQ.lppa.s...................................................................................................................................................................................................................................................................................................s-.Rll.l.pLslpls.ph.....hhDpFEW-hsp....tssPE......pFAhphst-LuLs.G.EFsssIAauI+tpl.h.h.p+...........................sh.h.st...tsh.s.p........................................................h...s.t.scpapPhl..LoptEhE+p.tcppRp.R.................................................................................	0	105	189	289
+4457	PF01174	SNO	UPF0030; 	SNO glutamine amidotransferase family	Belitsky B, Finn RD, Bateman A	anon	Prosite	Family	This family and its amidotransferase domain was first described in [1]. It is predicted that members of this family are involved in the pyridoxine biosynthetic pathway, based on the proximity and co-regulation of the corresponding genes and physical interaction between the members of Pfam:PF01174 and Pfam:PF01680 [2].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.28	0.71	-4.67	4	1876	2012-10-03 00:28:14	2003-04-07 12:59:11	14	6	1744	30	575	2672	2181	181.00	43	94.15	CHANGED	VLALQGAhhEHhctlc+ChsEs..........hsVKcsEpLspsDALIIPGGESTuMuhlhc+hGhh.sLhEFl+NspKshaGTCAGLIhLSpplusp...lhpLsLLcVsV+RNAFGRQspSFppch-Fpshh...psFsusFIRAPVI-clLss-sVplLh-hs....G..clVsAt.Qs.phLusSFHPELuEsshRhacaFlcphVp	.................................................VLALQGuhtEH..hp....h....l..c....p.h..G..s...cs...........................htV..+..p.hc.....c..L......p....p........l...D....GLIlPG..G.........E......S....T..T........h.s....+....L............h....c..p.......h....s....h.hpsl.....+.ph.lp.....s....................G....h..P...laGTCAGh.....I.l.L.......A.c....c.....l..t.st...............pp.....h.....L.....u.......t.......h..........D.........l.....s.........V.........c...R.............N..........A............F.........G............R.............Q.......l............-............S........F..........c......s..c........l..c........h....p..G..lu.........................t.s..h.......u....V.......F...I...R......A..P....h....lp.p........V.........G...................p....s......V...c...l..L...u.p.hs.........................s.....c.I.V...A..s+....Qs...shL.usSFHPE..L.....T..s....D...hR.lHpa.Flphh..t...........................................................................................................................	2	210	383	500
+4458	PF00080	Sod_Cu	sodcu; 	Copper/zinc superoxide dismutase (SODC)	Eddy SR	anon	Overington and HMM_iterative_training	Domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen.  Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding  family is one. Defects in the human SOD1 gene cause familial amyotrophic lateral sclerosis (Lou Gehrig's disease). Structure is an eight-stranded beta sandwich, similar to the immunoglobulin fold.	21.00	21.00	21.00	21.30	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.28	0.71	-4.04	127	3852	2009-09-11 05:27:43	2003-04-07 12:59:11	15	29	2380	488	1163	3237	322	143.20	32	72.64	CHANGED	Asshlpst...................ssp....ltGslphppss..ss......lplpsplpG...L.sP.........................G..hHGhHlHchGcs..sss..........stSAGuHa....NPts..tp..H.Gts..sst.................tHsGDLsNl..hs.sssGsu..phs..hhss.hl....sL.s.....sll....G.+ulVlHsstDDh...................popssGsuGsRlAC.GlI	............................................h...................tsp.......shGslph...ppp...s..ts.........lpl.ssp...l...p.G....L..ss..........................G.....HGFHlHp......h.Gs.....s...sss..............s.t.SA.......G.sH.a......sPts.....tp........H.suP....stt...............................tHhGDLssl..........hs...s....scG.p.A......phs...lhss..pl.........tlps.p.....slh.......G..+ulllHsssDshs.........................st.s.h..Gsu.GsRhACGlI................................................................................	0	373	655	952
+4459	PF00081	Sod_Fe_N	sodfe; 	Iron/manganese superoxide dismutases, alpha-hairpin domain	Eddy SR, Griffiths-Jones SR	anon	Overington and HMM_iterative_training	Domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen.  Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. N-terminal domain is a long alpha antiparallel hairpin.  A small fragment of YTRE_LEPBI matches well - sequencing error?	21.10	21.10	21.10	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.85	0.72	-3.72	25	8157	2009-01-15 18:05:59	2003-04-07 12:59:11	17	14	5135	325	1451	5799	936	79.40	42	40.82	CHANGED	sapLPsLPYsYsALEPHIScEThEhHHsKHHpsYVsN.LNshl-sh.-hspc...shEpllhp......shpsultNN.huGHhNHolaWpslu	...........................apLPtLP.Y..........s.h.s.A.L...c.P.a.lstcThchHHsK.HHp....T..........YVsNlNsul...c...st...p.....h...t.sp..........sl..E.c.l.lhp................................shpsu....l....h.NNuGG....HhNH.olFWcsLt..................................	0	485	915	1223
+4460	PF02777	Sod_Fe_C	sodfe_C; 	Iron/manganese superoxide dismutases, C-terminal domain	Eddy SR, Griffiths-Jones SR	anon	Overington and HMM_iterative_training	Domain	superoxide dismutases (SODs) catalyse the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the Mn/Fe-binding  family is one. In humans, there is a cytoplasmic Cu/Zn SOD, and a mitochondrial Mn/Fe SOD. C-terminal domain is a mixed alpha/beta fold.	20.90	20.90	21.10	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.56	0.72	-4.20	27	8609	2009-01-15 18:05:59	2003-04-07 12:59:11	13	16	5213	325	1661	6184	1017	97.60	44	50.45	CHANGED	G.E.Ps...GpLucAIscsFGSa-pFKppFspuAsuh.GSGWuWLVhc...sspLplhsssNtsss.hspG..hsPLLslDVWEHAYYlcYpNtRP-YlcsFW.slVNW-.sscca	.................................................Pp..GcLtsAI.cpsF.G...S...a-...p.FKp...p.F.s.s..AA.s..s.p.F......G.S.GWuWLV.......h.......s........................................s...............G......+..L.tl...s.s.TsNpssP...l.......s........p..........s.............t........h........PlLsl.DVW.E..HAYYl...........p.Y........p.......N.h......R....sc........Ylpsaa.sl.l.NWp.stp............................................	0	546	1040	1403
+4461	PF03002	Somatostatin		Somatostatin/Cortistatin family	Bateman A	anon	Pfam-B_1891 (release 6.4)	Family	Members of this family are hormones. Somatostatin inhibits the release of somatotropin. Cortistatin is a peptide that is related to the Somatostatins that is found to depresses neuronal electrical activity but, unlike somatostatin, induces low-frequency waves in the cerebral cortex and antagonises the effects of acetylcholine on hippocampal and cortical measures of excitability [1].	20.30	20.30	20.40	22.50	18.00	19.50	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.11	0.72	-5.88	0.72	-4.26	5	165	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	79	0	56	144	0	17.70	81	16.29	CHANGED	+-RKAGCKNFFWKoFTSC	....RERKAGCKNFFWKTFTSC	0	2	9	24
+4462	PF01680	SOR_SNZ	UPF0019; 	SOR/SNZ family	Belitsky B, Bateman A	anon	Pfam-B_2034 (release 4.1)	Family	Members of this family are enzymes involved in a new pathway of pyridoxine/pyridoxal 5-phosphate biosynthesis [1]. This family was formerly known as UPF0019.	20.40	20.40	20.40	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.37	0.70	-4.73	10	1980	2012-10-03 05:58:16	2003-04-07 12:59:11	12	7	1849	59	591	1309	540	205.00	67	69.72	CHANGED	pGotplK+GhApMLKGGVIMDVVNsEQA+IAE-AGAsAVMALERVPADIRAsGGVARMSDPphIcEIhsAVSIPVMAKsRIGHFVEAQILEAlGVDYIDESEVLTPAD.paHI-KcKFsVPFVCGARNLGEALRRIsEGAAMIRTKGEAGTGsVVEAVRHMRtlsu-IRclpsh.oEDELassAKcltuPY.ELlppltctG+LPVVNFAA	.............................pss.clK+GhApMLK..........GGVIMDVsss.EQ.................A........+IAE-AGAsAVMALERVPA.DIRAsG..GVuR.MSDPc.hI....cE....Ihp....AVSIPVMAKsRI.GHFVEAQlLEAlG..VDYIDESEVLTPAD-ta.HlcKppFpVPFVCGA+.sLGE...ALRRI.uEGAAMIRTKG...E.s.GTGslVEAVRHMRplsuEI++....l...p..sh..........s...........-....D....E....L.hshAK.-LtAPY.ELlpp.ltcp.G+LPVVNFAA...........................................................	1	227	402	516
+4463	PF02208	Sorb		Sorbin homologous domain	SMART	anon	Alignment kindly provided by SMART	Family	\N	21.10	21.10	21.80	23.60	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.52	0.72	-4.59	3	265	2009-09-11 11:43:11	2003-04-07 12:59:11	11	12	39	0	84	262	1	46.10	56	5.58	CHANGED	lKAsp..u.sshDEsGIPL...pTVDRPKDWYKTMFKQIHMVHKPs..sD	..........lKu.sph.uhGssDEsGIPl...poV..-RPKDWYKTMFKQIHhlp+..s.............	0	6	14	35
+4464	PF04203	Sortase		Sortase family	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The founder member of this family is S.aureus sortase,  a transpeptidase that attaches surface proteins by the  threonine of an LPXTG motif to the cell wall [1]. 	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.44	0.71	-4.54	138	4873	2009-01-15 18:05:59	2003-04-07 12:59:11	8	19	1737	74	783	3560	293	135.30	24	51.42	CHANGED	lpIPsls..lsh...s.lhp....s.....ss........tpsht.....Gsuahps.....ss...s.........Gt..ps.sslluGH....p.........sshFtpL.pcl.......c.tGDtlhlps................tsphh.pYc.......Vpsht.............l.....ss..ph......ph.....hs............pts...............pphlTLlTCs....sh.......................sspRhlVhuchs	................................................................................lpIPpls.......ls.h...P.lhp.......G...................ss.........ppsLtp............Gsuahcs.............sshs................Gt...ps....ss..llsG.H.........c.....hsssthF.s.s..L.p.ch.............................c.pGctlh.lps....................................tschh...sYc...............lpp.h.p........................................h.l.........pss....ch.......................ph.............lp.............................pts........................................cchlTLlTCs...sh..................sscRllVpuch...................................	0	283	543	695
+4465	PF04832	SOUL		SOUL heme-binding protein	Mifsud W	anon	Pfam-B_3872 (release 7.6)	Family	This family represents a group of putative heme-binding proteins [1]. Our family includes archaeal and bacterial homologues.	21.20	21.20	21.20	21.70	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.04	0.71	-4.74	71	715	2012-10-02 11:08:51	2003-04-07 12:59:11	7	16	287	15	420	683	1151	165.80	25	74.09	CHANGED	shEpPsYpVlpp.sss.......aElRcYsstlhA.........pspsp.ss.hcpu.sspuFphLssYI....hGp.Nps.....ppcIsMTuPVhpps..........................ttts.......................paphpFhh.Pupas.hps...hPtPsDs.plplpch.PupphAslpFSGhss-ppltppttpLpphLpppu...hp.....stu........sshhAtY...ssP.hs.shhRR.NElhl.lp	..................................................s..-ps.apllpp..tsp..........aE.lRpYt..s.h.hhs.................................ps.p..h...p......t.....hptu..hppu............F.tp.LhpYI........tGp..Npt..........ttcl.s.M.TsPVhpph.........................ps........................tps.....................phslpFhl..Psp.....a....p.........ps..........sPtP.s..cs...p.........lp.lp.ch..ss.hph.h.l..h.pFu..................G..h...s...s...pp..s..htp..ptppLtptL.pps.s......ht...........ts..................hhhutYssP...h..h.Rp.NElhh...t......................................	0	183	274	351
+4466	PF04267	SoxD		Sarcosine oxidase, delta subunit family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+).  This enzyme catalyses the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2 [1,2].	20.10	20.10	22.40	23.60	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.99	0.72	-4.16	89	550	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	367	8	172	490	1589	83.10	43	76.88	CHANGED	lIsCPhCGs.R-cpEFsatG-Ac.lsRPss..sus.s-cpWt-YlahR-NPtGhatEhWhHstGCtpWhsssRDTlTaElhs..shhAtp	....lIpCPaCG..RsEpEFshuG-A+.lsRPts......sss.hoDc-Wt-YlFhRcNP+Gh+tEhWhHstGCpcWFsssRD.TVTcclhssapst.p..........	0	36	89	125
+4467	PF04268	SoxG		Sarcosine oxidase, gamma subunit family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+).  This enzyme catalyses the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2 [1,2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.88	0.71	-4.35	6	546	2012-10-01 23:12:28	2003-04-07 12:59:11	7	2	369	7	174	1588	3279	147.50	26	76.56	CHANGED	RAhPup..AhsAslppuluhsLPstsssluoss...olhWluPDcahlls...Eutss.hAsLspulus.hu.ollDlStuRshIcloGspActlLsKusuhDLpscAFsVGtAssThhu+stshlh....RTGsDsFcllVhRSFA-phWchLp-uuuE	....................................................................t........thhtshp.p.s.hGhp.l.P...s.t..s..s..s...spss.....tslhWlGPD..E..WLlhs.......sp.s..t......s......h......tt...t....l....t....p...s..l....s....s......ht......u......l..l..-l......S........s...u..p...s...s..lcl...o....G.sps....c.p.................lL.s...+.u.s.......s....l...D.....L....p...s........p......s...F...s...s......G.....p....s.s...p....T....h....h.....s...+..s...s...l...h....lh................+...s...u...s....c...s...a.clhlh..R..SFA..cahhphLtcAut.....................................................	1	36	91	126
+4468	PF03172	Sp100		Sp100 domain	Bateman A	anon	Pfam-B_3126 (release 6.5)	Domain	The function of this domain is unknown.  It is about 105 amino acid residues in length and is predicted to be predominantly alpha helical. This domain is usually found at the amino terminus of protein that contain a SAND domain Pfam:PF01342.	20.60	20.60	20.60	22.00	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.37	0.72	-4.06	11	240	2009-01-15 18:05:59	2003-04-07 12:59:11	8	13	40	0	80	238	0	98.90	43	21.23	CHANGED	phhhEslhp+.FKcpKl-IAsAIc+sFPFLEGLRD+shITc+MYcDs.-uCRNLVPVs+VlYslLocL...E+sFshohLpsLFScVNLccYPcLppIh+SFpssht..s	......t.h.-shh++.F+ppKlEIA.AIp+sFPFLcuLRD+shIo-chac-s.-uh+N.LVPVp+VlYslLopL...E+s...F...s...hshLcsLFSclNLccYPcLhpIh+SFppsh..t....................	0	5	8	16
+4469	PF03014	SP2		Structural protein 2	Griffiths-Jones SR	anon	Pfam-B_1375 (release 6.4)	Family	This family represents structural protein 2 of the hepatitis E virus. The high basic amino acid content of this protein has lead to  the suggestion of a role in viral genomic RNA encapsidation.	28.00	28.00	28.00	28.70	27.90	27.80	hmmbuild  -o /dev/null HMM SEED	620	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-13.12	0.70	-6.64	2	3837	2012-10-04 01:49:40	2003-04-07 12:59:11	9	3	32	8	0	1287	0	127.50	61	98.02	CHANGED	hhGsphsSQ..sLP.................AGuR.tQ..Rs.uutWpsQ.QRPpuA.......sGsAPLTssssAssTtsVPDVDptGAlLhRQYNLsTSPLs.ushuuTNhlLYAAPlsPLhPLQDGTsopIMuTEuSNYAQYRV.thTlRaRPlVPNAVGGauIShuaWPQTToTPTSlDMNSITSTDVRlllQPG.Au.LsIPpERLtY+NpGWRSVETsuVspE-ATSGhlMlClHGoPhNSYTNosYTGsLGhlDFAlcLphRNLoPGNTNsRVoRhpsTA.Hpl+tsssG.AplTTsAAsRFMtDl+a.hGTstsGElG+GIhhsLFNLADTlLGGLPopLlpuAuGQhhYuRPVssANGEPpVKLYhSVEsA.pDKsIhlPHDIDLGsSpVshQDYsNQH.pDRPoPuPAPpRshusLRusDVLhlo.....lTsAE.....hsQshaGuuo.......ThhhhNlhTGspAsApSlDWoKsTlDGh.lpTlpt.Sto..FhsLPhhGK.uhW..GsptAGY.YpYNoTtp-.I.hlpN..GppVsh.sYTs.LGt..oshShlh.ltPhpA.......sD.P..httHThsD.CspChsLGLpsCshQu...pssEhpRLh.+lu+Th.S	.......................................................................................................................................................................................................................................................................................PVNSYTNTPYTGA......LGLLDFALELEFRNLTPGNTNTR.VSRY...oS.oARH+LRRGADGTAEL...T.TTAATRFMKDLHF...TGTNG.VGEVGRGIALTL..FNLADTLLGGLP..............................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+4470	PF02090	SPAM		Salmonella surface presentation of antigen gene type M protein	Mian N, Bateman A	anon	IPR002954	Family	\N	25.00	25.00	25.80	25.60	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.87	0.71	-4.21	4	199	2009-09-11 15:23:32	2003-04-07 12:59:11	10	1	185	0	4	50	0	140.00	66	98.38	CHANGED	MHSLTRIKVLQRRCTVFHSQCESILLRYQDEDRtLQAEEEAIlEQIAGLKLLLDTLRAENRQLSREEIYSLLRKQSIVRRQIKDLELQITQIQEKRsELEKKREEFQEKSKYWLRKEGNYQRWIlRQKRhYIQREIQQEEAESEEII	.................MHSLoRIKVLQRRCTVFHSQCESILLRYQDEDRtLQAEEEAIlEQIAGLKLLLDTLRAENRQLSREEIYoLLRKQSIVRRQIKDLELQIlQIQEKRsELEKKREEFQcKSKYWLRKEGNYQRWIIRQKRpYIQREIQQEEAESEEII......	0	2	2	3
+4471	PF02510	SPAN		Surface presentation of antigens protein	Mian N, Bateman A	anon	Pfam-B_1678 (release 5.4)	Family	Surface presentation of antigens protein (SPAN), also know as invasion protein invJ, is a Salmonella secretory pathway protein involved in presentation of determinants required for mammalian host cell invasion. 	20.10	20.10	20.90	20.60	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.97	0.70	-5.39	2	189	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	170	0	7	96	0	271.70	61	90.70	CHANGED	MGDVSuVSSStNhLLPQQDEVuGLSEALKKAlEKHKTEY.sDKKDREYGDoFVMHKETALPVLLsAhRpGAPAKSEpHsGpsSGLpHNsKG-FRIAEKLLKVTuEKSVsLlus.tKsDKoAALLSS+NhQlttVuuKKLSsDLKA...VSELADNshtloDDNlKA..sDpKsIsGEGlRKEGs.LAtDVAsSRhAAsNTuKuDDKDHKKIKEssQLPlQPTTIADLSQLSGGDEpMPLAApSK.hMThFPhADGVKt-DsSLTYRFQRWGNDYSVNIQARQsGEFSLlPSNTQVEHRLHDQWQNGNPQRWHLhRDDQQNPQQQQHtQpSGEEDDA	......................................................................................................................................................MGDVSAVSSSGNILLPQQDEVGGLSEALKKAVEKHKTEYSscKKDRDYGDAFVMHKETALPVLLAAWRHGA.AKSEHHNGNVSGLHHNGKGELRIAEKLLKVTAEKSVGLISAEAKVDKSAALLSsKNRPLEuVSGKKLSADLKAVESVSEVsDNATGISDDNIKALPGDNKAIAGEGVRKEGA.......PLARDVAPARMAAANTGKP-DKDHKKVKDVSQLPLQPTTIADLSQLTGGDEKMPLAAQS..KPMMTIFPTADG.VKGEDS....S.LTYRFQRW..GNDYSVNI....QA.....R...QA.GEFSLIPSNTQVE...HRLHD.QWQN.GN.PQRWHLTRDDQQNPQQQQ.HRQQSGEEDDA..........	0	2	3	4
+4472	PF04573	SPC22		Signal peptidase subunit	Waterfield DI, Finn RD	anon	Pfam-B_4675 (release 7.5)	Family	Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals.  This family is common to yeast and mammals  [1,2].	25.00	25.00	30.20	25.20	24.00	24.40	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.14	0.71	-5.04	14	439	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	303	0	302	411	5	141.80	28	86.75	CHANGED	MpohlsRuNul.huaoLolhAhlshssahSsh.FpchpssssIpshc..hhl+slpcFs.sspc+sDhuhlTFDLssDLspLFNWNsKQLFlYLoAEYcTtpNt.lNQVVlWDKIIhcs-puplsh+shpoK...YhFaDsGsGL+Gt+NloLsLpWNVhPpsGhLshspus.GphshsFPspYp	....................................................ph..Rhpth.hs.h.h....s..h.hhh...hh....hhh..h.s.h....h........p..s......s..s.p..l.p..........................h..ph.p..ah.....h.tp...t...p-.s...lpFs.ls...........sD.......L...p.....s.........l.....Fs.WNsKQlFlYlsAcY........to.....t........p......s.........t.....h.......N.....pl.....slWDpIl...pt......-.p.......s.h...lthp.s.......psK............Y.hh.D...s..s.tl........tt.pshslplpasl.P.sGhl.hs.p...........................................................	0	87	158	247
+4473	PF05122	SpdB		Mobile element transfer protein	Yeats C	anon	Yeats C	Domain	This proteins are involved in transferring a group of integrating conjugative DNA elements, such as pSAM2 from Streptomyces ambofaciens ([1]). Their precise role is not known. 	25.00	25.00	53.50	53.30	19.80	17.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.77	0.72	-3.94	3	33	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	23	0	10	35	0	52.40	68	85.52	CHANGED	MRIGPVQIGTHRDRHGQTKHAAVCTNDGCGWSADYTSQSAAQLAARTHRCKVS	....RIGPVQVGTahDpR.G+pKHsAACTAPRCGFSADYsSRuAAELAARTHRC.Vp..	0	2	8	10
+4474	PF03771	SPDY	DUF317; 	Domain of unknown function (DUF317)	Yeats C	anon	Yeats C	Domain	This a sequence family found in a set of bacterial proteins with no known function. This domain is currently only found in streptomyces bacteria.\	     Most proteins contain two copies of this domain.	25.00	25.00	26.20	25.10	24.00	24.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.19	0.72	-4.48	16	112	2009-01-15 18:05:59	2003-04-07 12:59:11	11	2	16	0	67	132	0	64.50	25	43.21	CHANGED	hsSPDupstlpaps.........tsssssWpl.....hsssssststWpApFsspsPscLluuhssuL.ssssshpc	.......................SPDthhhlta.s.........sstsssWpl.....tsssssssstWtAsFsspTPs-llAuhssuL.sssts................	0	17	57	67
+4475	PF00435	Spectrin	spectrin; 	Spectrin repeat	Bateman A, Finn RD, Stabach P	anon	Pfam-B_1 (release 1.0)	Domain	Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure.  These include spectrin, alpha-actinin and dystrophin.  The sequence repeat used in this family is taken from the structural repeat in reference [2]. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteristic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in ultiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.14	0.72	-3.75	83	21182	2009-09-14 14:25:53	2003-04-07 12:59:11	16	452	349	133	9769	19145	10	103.80	17	36.64	CHANGED	pphppFtpcss-hppWlpcp.cthl..ssp-h.spclsslpsLhc...+Hcthcp-lss.ppsplpplp....phuppL.hspt...t.ss...pplpp+hpplsppWppLpphstpRcppLpp	............................................t..hppF...pphpp..h...t...sWlp........c.p.....c...t.............h...l.......p.s..p...s.....h.....u......p...s..h....p.....s....l..p.....t......hlc....................ca..c..s..h.p......p....-..l...p...........s...p..pspl.p.p.lp..............................ptup.pL....hppt................t.ps.....................ppl...p.pp...hpp........l......p.p...pW..p...p.L.pp.hht.p..RpppLt.........................................................	0	2238	2954	5943
+4476	PF01564	Spermine_synth		Spermine/spermidine synthase	Bateman A	anon	Pfam-B_798 (release 4.0)	Family	Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.43	0.70	-5.44	17	3831	2012-10-10 17:06:42	2003-04-07 12:59:11	12	30	2623	95	1322	3677	1590	224.20	28	64.46	CHANGED	hWFpEh.s.....................hss.uhsh+VcclLact+ScaQclhlaco...........psaGclLl............LDGslQhoEcDEahYpEhlsHlshhs+s.....NP++VLlIGGGD........................GGsLREllKHssV.............EclshV-IDptVI-hu+calPphuss......hpcs+lpl.hlsDGhpalpphps.....paDlIIsDsoD.PhGPucs.....LFpctaachhtcsLptsGlhssQu..cs.alphchhpslhpsh+psh...sthhhsslPTYssshhsahlsocp........ps	.............................................................................................................................................................................h....................................htht.p..lhptp.o..a.Qcl.l..h.cs.......................ta.Gphhh..........................LDG......h....l.....h..o......p.....t..DE....a....h.Y...pE......h....hs....H...ss..hh.s.cs..............p.s.+.+.VLl.lG...G.GD..............................................................G...u.s...l.R.E...l...h..+a.......s.l...............................................................................................c..p.ls...h..V..E...I....D.......t....t..Vlc.h..s....+....p....a...h..s.p.hsss...........................hcDs...Rhpl..hlsD..Gh.p..alpp.spp....................paD.....lI........I..s.....D......s......o.....D...P..........h....G.............s.ups............La..o.....p.t.FY.pt.s.tc.sLp.s.s.G.l..hls...Qs........tss.h..h..p.......p.....h..h.p.h...h.p.p.h.p..p........h.......F.............st........h.s.lPoa.s.t.hhhhhhtpt...........tshtt....................................................................	0	463	818	1110
+4477	PF02819	Toxin_9	spidertoxin; 	Spider toxin	Griffiths-Jones SR	anon	Homstrad	Family	This family of spider neurotoxins are thought to be calcium ion channel inhibitors.	21.30	21.30	21.50	21.70	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.11	0.72	-3.89	6	29	2012-10-01 22:06:18	2003-04-07 12:59:11	10	1	12	6	5	49	0	39.90	38	58.82	CHANGED	Chu.sYc+CshGtpPCCcsR.sCcCslhhsNCcCK..+hlhEhhGhu	...Chs.hhcpCshsppsCCcsp.sCpCshhssNCcCp..+hh..............	0	1	2	5
+4478	PF02513	Spin-Ssty		Spin/Ssty Family	Staub E, Mian N, Bateman A	anon	Staub E	Repeat	Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo [1]. The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis  and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.	25.00	25.00	25.70	28.00	22.10	18.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.28	0.72	-4.40	27	646	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	56	6	298	766	0	48.10	42	57.44	CHANGED	VGppVpHhac-s..t.hspWcGhVLsQlPspsolaaIKY-sDsslYshpLh	..lG+pVpHsa--G.pt...shscW+GhVLsQVPspPolYaIKY-sDsslYsYpLh..........	0	15	29	99
+4479	PF05215	Spiralin		Spiralin	Moxon SJ	anon	Pfam-B_6625 (release 7.7)	Family	This family consists of Spiralin proteins found in spiroplasma bacteria. Spiroplasmas are helically shaped pathogenic bacteria related to the  mycoplasmas. The surface of spiroplasma bacteria is crowded with the  membrane-anchored lipoprotein spiralin whose structure and function are  unknown although its cellular function is thought to be a structural and  mechanical one rather than a catalytic one [1].	20.80	20.80	20.80	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.55	0.70	-5.25	4	22	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	13	0	0	21	2	211.00	67	98.10	CHANGED	K+LLSILAVFGVSAVGTTSVlACNKTESNNLSRVKTIAAPtTVAAtssppVTKtEIKsuL-sNVLKAVQGVVKTApAsDF.aEVYpDNcGpAL-TlNLcAGpV-VYVQITPAKDKTVVIGKoGYIKVTLPKt...hKsDISsVTVsEQTVtIKsusPpsVTKsELpAVNp.AsLApAVLsAIKsKsssstAS-FtITNNGstGsYSAsKsVEVTVKApDsSspIoGpFKFNAKVTAThs	KKLLSILAVFGVSAVGTTSVVACNK.TESNNLShVKTIAAPATVAstp........PKpVT+sEIKTALE....ANVLKAVQGVVKTATAA.DFQFDVYpssKGT.uLpTIsLEuGpV-VYVQITPAKDKTVVIGKoGYIKVTLPK....hKVDIpsVslspQhVtIKAucPKpVpKDELNAVNT.sTLApAVL-AIpphAPNAG..ASDFEITNNsstGsYpstK-VcVTVKAKs-SsNISGpFKhpAKVpAhh...........	0	0	0	0
+4480	PF03533	SPO11_like		SPO11 homologue	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.10	21.10	21.20	22.50	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.17	0.72	-4.08	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	23	0	15	36	0	42.20	74	10.96	CHANGED	AFAPMGPEASFFDVLDRHRASLLAuLRRGGGEPPuGGTRLASS	......AFAPMGPEASFF-VLDRHRtSLLAALRRGGtEPPuGGoRlASS....	0	1	2	3
+4481	PF05032	Spo12		Spo12 family	Wood V	anon	Pfam-B_51047 (release 7.6)	Family	This family of proteins includes Spo12 from S. cerevisiae Swiss:P17123. The Spo12 protein plays a regulatory role in two of the most fundamental processes of biology, mitosis and meiosis, and yet its biochemical function remains elusive [1]. Spo12 is a nuclear protein [2]. Spo12 is a component of the FEAR (Cdc fourteen early anaphase release) regulatory network, that promotes Cdc14 release from the nucleolus during early anaphase [3]. The FEAR network is comprised of the polo kinase Cdc5, the separase Esp1, the kinetochore-associated protein Slk19, and Spo12 [3].	20.50	20.50	21.10	21.30	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.40	0.72	-7.57	0.72	-4.33	9	136	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	117	0	96	116	0	34.20	45	21.64	CHANGED	ASPTDsLlSPCSpKLs-HKuKhFtt+spPspLths	..SPSDslhSPCopKLsshKsKpat.pt.ppsphhh...............	1	27	53	81
+4482	PF03907	Spo7		Spo7-like protein	Wood V, Bateman A	anon	Wood V	Family	S. cerevisiae Spo7 Swiss:P18410 has an unknown function, but has a role in formation of a spherical nucleus and meiotic division [1].	34.10	34.10	34.70	37.70	21.60	34.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.29	0.70	-4.72	9	132	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	128	0	99	124	0	205.40	40	52.65	CHANGED	SPsuhIFRNLLILE-sLRcQshp.+hh+hQaThFLohLhulssahhYtLYasscps....pG.......lhRhhLphsllhhhlTllLFHlSGpY+RTIVlPRRFhs.TNKGlRtFNlKLVKl+ssa.cchhD.lRhh.h.ls...la.hphhlhhutps..u.hhpFhpsspl+spsR...........................lGusDVKLlLsP+sFos-IREGWEIYRsEFWs+EusRRRcppp	...........................................SssstIYhNLLILEsuLRtQhlpLRtRRRpaThFLhlLshhluahsYt.Lahpscpsu...pG..................................hlchh.phsLhu.ullTslLhasoGpacRsItaPRRalssoN+GLRshNsKl.Vhl+ssWhpch.hshlta...............hphhh.....t.ts...u...tahps.s..pp..p................................................................................Gus.lKLlL.s+sFSsphREsW-.YRsEaWt+.EstRRt...h..........................	0	23	51	83
+4483	PF01052	SpoA	SPOA_protein;	Surface presentation of antigens (SPOA)	Finn RD, Bateman A	anon	Pfam-B_408 (release 3.0)	Family	This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, Pfam:PF02154.	23.00	23.00	23.30	23.20	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.01	0.72	-4.38	130	6032	2009-01-15 18:05:59	2003-04-07 12:59:11	15	12	2189	8	1289	3714	814	75.30	26	29.28	CHANGED	ltpplppsslplpshluctplslp-lhpLpsGcllsLsps.htctlplhl....ssphlhpGchs...thss....phulclpchhppp	............h..t.l.clslplssplGcsphslp-lLpLp.GsVltL-p...ss-...s..lc.l.h.l....suthlupGcls...slss....phul+lscllp..s.......	0	420	802	1028
+4484	PF05036	SPOR		Sporulation related domain	Bateman A	anon	COG3147	Domain	This 70 residue domain is composed of two 35 residue repeats found in proteins involved in sporulation and cell division such as FtsN, DedD, and CwlM.  This domain is involved in binding peptidoglycan [1]. Two tandem repeats fold into a pseudo-2-fold symmetric single-domain structure containing numerous contacts between the repeats [1]. FtsN is an essential cell division protein with a simple bitopic topology, a short N-terminal cytoplasmic segment fused to a large carboxy periplasmic domain through a single transmembrane domain. These repeats lay at the periplasmic C-terminus. FtsN localises to the septum ring complex.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.47	0.72	-3.82	136	7624	2009-01-15 18:05:59	2003-04-07 12:59:11	8	118	2474	2	1762	5585	1681	74.80	19	23.88	CHANGED	ssssahlQlu.uhs...spssAcphhscLptp.sht...........sthpssssha+Vhl.GsasspppA..pphtp.pLp.......tthsshlhp	.........................................t..ttahlQlu.uhp..........stspA....pp....h.tt..p....Lptp..uhs..................sphtsss..shaRlhl.G.....sass+ppA....pphhp.pLp......tthpshh..h..................................	0	527	1100	1450
+4487	PF03845	Spore_permease		Spore germination protein	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.94	0.70	-5.78	17	1773	2012-10-03 01:44:59	2003-04-07 12:59:11	8	5	343	0	394	2732	134	306.50	19	86.06	CHANGED	plostQhhhlIhsh.lGsGlLshstshAcps.t..uWIullluullshlhhhlhhhlhpp..asppslhphhpchhG.KhLGtllshlahhYFlhhush.lRshuEllthahh.csPhahlshhhhhlslYhlhpGlcsluR....hhhhhhhhhhhhhhlhlhshphhchcNLhPlhspGlhslL+u..stsshhsasshElhlhlhsahpspKpst+hshhuhhlsslhYhloshlsIsshus-hsppthaPtlshhcslcls..hl-Rh-hhhlhlahlhhFhshslhhausshuhsplF+hpppp......hlhhlhslhhlhs.lhpsts.h	..............................................................................................................................ls.hphhhhlh...h....lG..s..u.....l.L...sh...sph...hs..pts...t..D....u.....W.l..u...l...l.l.u......sl.hs....h.l..h.h..h...h..h....h.h....l.h.pp............h.s..s..t......s......h....h...p..h.h.........p.p.h..h......G....+........h......l.G.......p......l......l.s.....h....l.......a.......h....h.......a....h...h....h....h.s...s.......h..h...........l.......p....s....h....s.....p.......l...l.p...h...a......l...........h.............s............p.................T...P..h..h..............h..............l..............h............h..............h..............h.h...l.........l.........s.h.........Y....h....s........t.t..G.......hc.........s...ls+............hhthh....h...s...h.h....h.l...h...h....h.h.....l.........h....h..........h............s...........h..........p.................h..........c............h.........p....p........l........h......P...............l............h.......p............p.........u.......h...h........s........l.....lpu........sth.s..h...h....s....a....h..uh.t....l.h.h.....h.l.h.P.a.l....p......p....p.....p....p..h..h.+.....s.h.h...h.u..h....h......h.s.s.l..h.h......hh.h.sl.hsl.s.hh.......u..p.th..tp..h..haP.s...l.ph.h..+h.l.p.ls.......a..l-.R.h.-h....lhl.....h...h....Wh....h....s..lhss..h.....s.hhh.a.sssh..s..hp....p.........l.........h.p.h...pppp........hl.h.h.h.h.s.l..l..hh.h.s.hh........h..............................................................................................................................	0	202	327	345
+4488	PF00588	SpoU_methylase		SpoU rRNA Methylase family	Bateman A	anon	MRC-LMB Genome group	Family	This family of proteins probably use S-AdoMet. 	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.89	0.71	-4.31	139	17854	2012-10-01 22:53:19	2003-04-07 12:59:11	14	38	4871	41	4348	12081	7850	141.80	26	56.74	CHANGED	shhllLsplpcPtNlGulhRostshGs.pslhl..hp.psh...hssp....sh+s.uhGu.h.hls.hhhh...sshpc.hlpp..lcpt.s.hhl..hus....sh....pup......shh...........ph....sht.......pthsllhGsEspGlspphhctsc.t..hlpIPh.tsph.pSLNlusAsul.hla	...........................................................................................s.hhllLppspcPtNlGslhRossshGs....p...s...lhl.............s.....p........t....sh...................s..tp.................s.h+s.....uhG....u......hp.h..l....s...l.hhh.................s..s............l..s..p.....h............l.p..p............hptt....t.....h...h.l..............hus....st........sup............shh...............ch.............shs......................................................tshsllh......GsE......sp.G..l...s...p..p....h........h....p..t.....s....-....t...............hl.p.I.........P........h......t............s............p.............s.....p...............S.LNlus.AsullhY...............................................	0	1420	2797	3687
+4489	PF03862	SpoVA	spoVA;	SpoVA protein	Finn RD	anon	DOMO:DM07026;	Family	Members of this family are all transcribed from the spoVA operon. These proteins are poorly characterised, but are thought to be involved in dipicolinic acid transport into the developing forespore during sporulation [1].	25.00	25.00	27.40	26.90	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.38	0.71	-4.00	73	1094	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	417	0	209	677	19	114.50	41	85.14	CHANGED	hs.hlpAFlVGGlICsIGQllhshh.....h..chssshshlshlhlGulLTGlGlY-clucaAGAGusVPlTGFuNulsuuAlEappEGhlhGlusshFplAGslIsaGlhsualhuLIa	.....shlhAFlVGGlICslGQllhchh...........+hssshshsohVhlGAlLsGh.....GlYDclspFAGAGusVPlTGFGNSlspuAhEttpc..shllGlus...shFcluuusIshullhualhuLI............................................	0	103	167	179
+4490	PF04026	SpoVG		SpoVG	Kerrison ND, Finn RD	anon	COG2088	Family	Stage V sporulation protein G. Essential for sporulation and specific to stage V sporulation in Bacillus megaterium and subtilis [2]. In B. subtilis, expression decreases after 30-60 minutes of cold shock [1].	22.00	22.00	22.50	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.89	0.72	-3.95	34	963	2009-09-11 01:05:24	2003-04-07 12:59:11	7	3	793	10	180	528	40	83.90	54	80.87	CHANGED	MplTDVRl+plssc...u+lKAhsSlThDssFVV+DlKVI-G.ppG.LFlAMPSRKst-....................................Gpa+DIAHPIssEhRpplpcuVlctYccth	.............................................MplTDVRlR...+.lps-......G+MKAlsSITl..Dc....p.FVlHDl+V.I-G.psG.....LFVAMP...S+..+.Ts.D....................................GEFRDIAHPINS-hRpcIQcAVlptYcc..h.......................	0	100	147	165
+4491	PF04293	SpoVR		SpoVR like protein	Kerrison ND, Finn RD	anon	COG2719	Family	Family member Swiss:P37875 is Bacillus subtilis stage V sporulation protein R, which is involved in spore cortex formation [1].  Little is known about cortex biosynthesis, except that it depends on several sigma E  controlled genes, including spoVR [2].	18.50	18.50	19.80	19.00	18.30	16.30	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.78	0.70	-6.11	62	1383	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1289	0	332	906	166	407.70	54	84.95	CHANGED	us-WsFchLpphpccIpclA.ccaGLDsYPsQlElIouEQMhDAYASsGMPltYpHWSFGKpFhpscptY++GhhGLAYEIVINSsPCIAYLMEENohsMQsLVlAHAsYGHNsFFKsNaLF+pWTDApuIlDYLsFA+sYIscCE-+..aGh-tVEplLDusHALhsaGVDRYtRstplShpcEctRp.....p-Rctahp.pphN-LW..RTlP..........pcppttpp..............ppt.+aPtcPpENlLYFlEKpAPhLEsWQREllRIVRcluQYFYPQ+QTpVMNEGWAoFWHYsIhNcLacpGtlsDuhhlEFLpSHosVlhQP.hssPtaoGINPYsLGFshhpDIcRICppPT-ED+cWFP...-l.......AGs.shhcsLc.Ahcsa+DESFIpQaLSPclhR-h+LFsltD-sccs..hpVsuIHsEcGY+plRcpLuppYslush-PsIQVhclDhpGDR	............................................GsDWTF-LLchYhsEIc+lA.chYtLDsYPpQIE.lITuEQMMDAYuSlGMPlsYsHWSFGK+FlcTEphY++GQpGLAYEIV.......INSNPCIAYLMEENTlsMQAL.VhAHAsYGHNSFFKNNYLF.................+sWT......D...................A..s........u....I..lD..............YLlFA+pYIscCEER..YGl-EVEclLDSCHALMNaGVDRY........K....RP.p.K.l.S...h.pE.E.csRp..........................cpREcY..LQ....SQVN....LW....RTlP+.......................cc.ccp..ps.................t...ct+RaPs..E.PQENlLYFh..........E..........Kp..........AP..........L..........L..........E....s....WQREILRIVRKluQYFYPQ+QTQV..MNEGWATFWHYTILNcLY-.......cGclT-.cFMlEFL+SHTsVVhQPsasuPaaSGINPYALGFAMFpDI+RICpsP.........T-.......E.D+.hWFP...........-l............AGu..cWL-sL+aAMcsFKDESFIsQaLSP+lhR-h+hFslhDD-+csh.lcluAIHs-cGY+pIRppLusQYsLushEPNIQVasVDh+GDR..................................................	0	93	198	268
+4492	PF04232	SpoVS		Stage V sporulation protein S (SpoVS)	Kerrison ND, Finn RD	anon	COG2359	Family	In Bacillus subtilis this protein interferes with sporulation at an early stage and this inhibitory effect is overcome by SpoIIB and SpoVG.  SpoVS seems to play a positive role in allowing progression beyond stage V of sporulation.  Null mutations in the spoVS gene block sporulation at stage V, impairing the development of heat resistance and coat assembly [1].	20.60	20.60	21.50	21.00	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.72	0.72	-4.41	26	629	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	425	4	199	331	10	85.30	63	87.47	CHANGED	ME.lLKVSu+SsPsuVAGAlAullRcpupsElQAIGAGAlNQAVKAlAIARGalAPsGlDLlslPAFs-lpI-GE-RTAIKhlVpsR	.........MElLKVSu+.SsPNSVAGALAGVlR.E+..G.sA..EIQAI...GA.......GAlNQAVKAlAIAR.G.FV...AP..oGl..DL.lClPAFs-IpI.DG...E....ERTAIKLIVpP........................	1	106	166	186
+4493	PF03539	Spuma_A9PTase		Spumavirus aspartic protease (A9)	Griffiths-Jones SR	anon	PRINTS	Family	\N	20.90	20.90	21.00	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.03	0.71	-4.32	4	22	2012-10-02 15:32:34	2003-04-07 12:59:11	9	6	15	1	2	24	0	147.80	49	14.35	CHANGED	IKGs+LKGaWDSGA-ITCVPthaL.-EcPltpphIpTIHGppcpDVYYlshKIpGRKlpsEVIuTsLDYlllsPuDlPWhhKtPLELTIKlDlccQQcpLLpposLSpcGKchLKcLF.KYsALWQpWENQVGHRRIcPHKIATGTLpP+PQKQY+INPKAKs	.........................hKGsKLpuaWDSGApITClPpsaLppEpPltpp.lpTIHGppppsVYYlphKlpGRKlpsEVIuosh-YhllsPsDlPWhhppPLpLTlhlslp-.pcplLpposLscctKppLppLhpKYssLWQpWENQVGHR+IpPHpIATGThtP+PQKQY.INPKAKs....	1	2	2	2
+4494	PF03779	SPW		SPW repeat	Yeats C	anon	Yeats C	Repeat	A short repeat found in a small family  of membrane-bound proteins. This repeat contains a conserved SPW motif in the first of two transmembrane helices.	20.80	20.80	20.90	21.00	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.78	0.72	-4.59	16	414	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	200	0	160	360	9	51.30	29	53.28	CHANGED	hpWshsllGlWhllSPWIl.Ga.ossuuhhhsslIsGllVslLu...lhhutsspc	.............hhshllGl...alhhSPWll..Ga...uss.s.u..hhhss.llsGlllslLu.....hhhh.....t.............	0	38	108	138
+4495	PF00494	SQS_PSY		Squalene/phytoene synthase	Finn RD	anon	Prosite	Domain	\N	26.00	26.00	26.00	26.10	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.85	0.70	-5.10	152	3383	2009-01-15 18:05:59	2003-04-07 12:59:11	14	23	1893	58	1260	3142	2434	253.00	23	78.59	CHANGED	hcptucoFhhushhLs.tphRpslhslYuasRhsD-lsDpss...............s.stttph..................Lptacptlpthh................................................t......ps....lh.......................psltpshpphp.........lshp..hhtpllcuh....thDlp....................................pp........hh.ohs-.........LppYshtsAus..VGhhhhplh...sh..............ssp.......t..hphA............................p.....p...........lGhAhQlsNllRDlscD................htp...GR.hYLPt-..hh.tp..........sls.p.....plht........................stt.hpthhp.........................phhstAcphhpputshltt.............................l.sttsphshhhshslh.ttlLc...p.lcpssht.h.....hp..tRsplsthc	...............................................................................................................................................h..phucoFhhuh.hhLs..tph.Rpslhs.lYshsRthD..-..lsDsss...............sst.tth..................h.Lptacppl.pp.hh............................................................................................ht.stcs..lh..........................................tsL.t.p.sh...p.pat....................lshp...htshl....suh.....thD..lpt........................sp.........ht.shs-L.tt..YChtsAus..VGhhhstlh.uh..t..............................................pst...............ts..hphA............................pp........lGhAhQl.sNllR.DlsED.....................................hpp......GR..lY...lPt-....h..tp.......h..sl...s....p.....clhttt............................stt..ht..phhp.........................thhppAc.phhppu.ht.hlst.........................................l...s..t..p..s..t..h..sh..h...hshhhh.hthLpt.lptssh..t.h........p...t+h.l....t............................................................................................................	0	384	788	1058
+4496	PF00299	Squash	squash; 	Squash family serine protease inhibitor	Finn RD	anon	Prosite	Domain	\N	22.00	22.00	23.20	26.10	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.73	0.72	-4.13	12	37	2012-10-01 19:46:11	2003-04-07 12:59:11	13	1	17	32	0	60	0	28.70	64	90.24	CHANGED	RhCPRILMcCK+DSDCLucClClcph.aCG	..RhCPRILMcCKpDSDCLupClChcp.G.aCG...	0	0	0	0
+4497	PF02117	7TM_GPCR_Sra	Sra; 7TM_GCPR_Sra; 	Serpentine type 7TM GPCR chemoreceptor Sra	Mian N, Bateman A	anon	IPR000344	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Sra is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	18.90	18.90	19.40	19.10	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.96	0.70	-5.82	10	141	2012-10-03 04:04:29	2003-04-07 12:59:11	11	3	7	0	141	262	0	276.40	20	94.23	CHANGED	MSs.sCAScsclpRhsSLNF+IuQalsLlsIllTFIhTYaAlKllhp+SIFplSTKILLhpNLFaANLHQlhYuIpslphLY+uFFhls-PCshLpoEt-CthYhcVLlsGsSGMlYuQTGLLIERsCATFl+sYcpKpShhsGlsISIlVLhsShuTu+IIIWDDPL-salLuCahaPpcSssRushFhsIsTlLolFNLllSllIh+YNK+LEY..STRFpVusRFpKRElI-STpTICFLshoQFlhhFlYShGlhlL+pI+..phIshcpaahhVVWsYTlPFIAlhFPlLLIYRIRpo+ssRsphIpplTspKQTQ-EHI+QhKshW	.........................................................................................................................................s....h.h.h.pS..hhhs.h...h...hhh...h.h.o...h...h.hshh...u...l.....p.hl....hp...p...s...l....a..........p.....u....T+....hLLh..slh.ss...hHp.h..h...............h.....h.......................t......hh...................l....h..........+s.....h..h..h.....sc.sCp.lh..h.pp.....-Ch.........h.h.h.hh.h...s....h...h...h.h....h..ph......u....Lh.l-R..............hhup.h.h...p.h......t.ph.phh..u..h.h...............l......h....hhlh....h.oh.................h........s.h....hh.....h....h.h....s...s...sh...ss.h.h...s.C.hh.....st......s.h..t..p.........h....p....h..hhh..h..hh..h.l...s...lh..s.h.l..h..s.h..h....lh.hh....s.....p.+.h.ch...............p.pp.apl...t........tRapp..hEsl.oopsl...s..hlsh....hQhlhh...hla.shs.h....hhhh...h..p..p...h...s.......h....a....h......h..h.....a.h..a...............s...h..s.ahs...h...hhPhllh.h.p....h..p.http.R...t.......t....I....t.t.h.pt..t........ts....pp.a.h.tp.hpt.W................................................................	0	43	57	141
+4498	PF02175	7TM_GPCR_Srb	Srb; 	Serpentine type 7TM GPCR chemoreceptor Srb	Mian N, Bateman A	anon	IPR002184	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srb is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	21.70	21.70	21.90	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.64	0.70	-4.81	3	69	2012-10-03 04:04:29	2003-04-07 12:59:11	11	4	5	0	68	166	0	199.20	35	65.84	CHANGED	FHPVYRlAQFYoFhVSsFAhPuLIYFMFcKLFKLsFHGNLKsLLIuYFIolLLFAlhlCFsFGYQFFVPFFl+SNCDLIINuTLFKYGHsoulFlMTlPMlLPluFTIERFsAMKMAcoYE+lRTLLGPVLVllLIIIDshhlYhIappEsFDcsFISFlllPuToA.LsFNoFLWalLYLNIsNFlhNllLLhlH+KLKpRhhh+NoSLSTKYplEEISQSS+FTLIVTFTHLLFF	...........................................................apslaRhu.haphhluhhuh..sLh...a...F...lhh...+l.h...................F..HsNL.K.......h..............l....h..hsYFhshhl...auh...........hhh.h...s.h............h...hphh....h....P.F...........h....s..p...s.p.CsL....l...I.s.......h...h....aKh..hphhhh.hhhTh...s..hhh..P.huhoIERalAhth.AcpYEps..s.hLGPl.L..s...h..h..h...............h.hh.shhl.....hhhlac.s.....E.pFs.ss.l.S.F....hh..h..P.ss......s..........A.........p..h......a...h.h..h..L...l..hl.p.hhNhl.h..N.hhL.lhh......p....p..+h.Kp...................................pps.o..Los+Yph.EE....lhpS.oK.Fs.l..h..lhF.hHllFF.........................................................................................	0	13	20	68
+4499	PF00530	SRCR		Scavenger receptor cysteine-rich domain	Bateman A	anon	Reference [1]	Domain	These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.	26.10	26.10	26.10	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-11.18	0.72	-3.66	136	8985	2012-10-03 20:35:02	2003-04-07 12:59:11	13	369	133	13	6194	7713	21	96.30	35	47.20	CHANGED	ssGss...spGRVEl.h.........s.G.........pWGsVCss.s.......Wshp..sApVlCRp..LG........h.ssshps.tsssh...........ts.ts.....lh..hss.....lp......CpG.sEssLtpC...........pshst..ps...C.sp.t..ps....suVhCp	..............................................................................sGsst...s..pG.RVEV.h.............s..G............pW.GT............V.CDc..s...........Ws....hp....-........Ap...VVCRQ....LG.................................h..usu.h..ps...tssta............................GtG..sGs.........lh....lcs..................lp........................C.......p.......G.....s.......E.........s..s....L...h.pC..........................t......ps.h.st......ps............C...sH...p......cD......Au.VhC...................................................................	0	3267	3815	4627
+4500	PF00319	SRF-TF	transcript_fact; 	SRF-type transcription factor (DNA-binding and dimerisation domain)	Finn RD	anon	Prosite & Pfam-B_6396 (Release 8.0)	Domain	\N	20.40	20.40	20.40	20.60	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.43	0.72	-4.73	10	5768	2009-01-15 18:05:59	2003-04-07 12:59:11	13	20	1081	36	1424	5480	5	47.50	55	19.44	CHANGED	KpIENpoNRpVTFSKR+sGlhKKAaELSVLCDs-VulIlaSssG+LaEauo	.................................+I-NptsRQVTFoK...R.R.sGLhKKAh.EL.S.VL..C.D.A-Vu.L.I..l.F....S..s.s....G..KL..a-aso................	0	300	819	1128
+4501	PF02118	Srg		Srg family chemoreceptor	Mian N, Bateman A	anon	IPR000609	Family	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.76	0.70	-4.96	49	400	2012-10-03 04:04:29	2003-04-07 12:59:11	16	10	7	0	395	556	0	228.30	17	81.72	CHANGED	hhlQhsYhlPuhhLhlhhlhhlhhs++...ahpsSFatLaphDhlsslhhhl.shhhsRlhhah..lC.hhs.h.hhssshhhshhhhhhhahhthphloplhlolsRho.sVhaPhpapphWp+hh..lllhlhllPahhlWshll...u.ps.lthh...tGshhhsahctl....assho...hapllahlhslhlslhoshlshh+lpths.p+hcplE+pLshhshhhohsahhhshhphh.....hshhhshhs..hhphhhhhhhhs.Dhhslut.............PhlLllhssplRppl	........................................................h.h.Yh..h.sh..h..lh....h.h...h....h...h....h....l...h...h...t...p..t......................pp..sF.....ah..l........h...hsh..........h.....h...............shhhhh...........shhh.Rh..h............s...h...h....h.....................t........s.......h........h....hp.h.h.h...hhh...a.hhh.....h....p.h.t...hhhshsRho.slh..h........h......p...............h...............p...............p..............h...W..p..............p........h......h.....h......h..h....h..hl..h..hh....s.h.h...h..h.h.phhh.............t.thh.h.......h.......s....s...h.h..h.......h....p.h..........................h..sth..............hh...h...h...h.....h..h.h.h..h.h..h...s...l..h...s...sh..h.......s..h....h............p.......h.........t..........t...............h..............t.......t............p..........h.............p............p..............h.............p........p..p....l...h.......h........h..s.h..h...h.sh....hhh....hhhhhphh................h...hh.t...........thhh.......h..hs...Dh...h....sls..............................................shhh.lhhstpl+t..............................................................................................	0	119	168	395
+4502	PF02290	SRP14		Signal recognition particle 14kD protein	Mian N, Bateman A	anon	Pfam-B_7955 (release 5.2)	Family	The signal recognition particle (SRP) is a multimeric protein  involved in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP14 and SRP9 form a complex essential for  SRP RNA binding.	21.20	21.20	21.90	21.90	20.70	18.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.37	0.72	-4.07	22	297	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	258	6	206	281	2	95.60	33	71.62	CHANGED	Lss-pFLocLocLapcsppcu..SValThK+h..........ssps.ps.spssp......shpp....ssp.tsLlRAosG....................pK.KlSTlVpsc-ltp..FhtsYuslh+upMsuL	.....................Lps-pFLscLscLap...pscppu..SValThK+h.......................................................shps..ps.spptp................spstp........ssp....sLlRA.o.sG.......................cK.KlST.............lV........psc-lsp..F.ttYuslhKusMsuL................	0	61	103	162
+4503	PF01922	SRP19		SRP19 protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The signal recognition particle (SRP) binds to the signal peptide of proteins as they are being translated. The binding of the SRP halts translation and the complex is then transported to the endoplasmic reticulum's cytoplasmic surface. The SRP then aids translocation of the protein through the ER membrane. The SRP is a ribonucleoprotein that is composed of a small RNA and several proteins. One of these proteins is the SRP19 protein [1] (Sec65 in yeast [2,3]).	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.09	0.72	-3.41	77	498	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	439	21	335	512	73	93.80	33	54.93	CHANGED	hllYPsYlDsp+o+scGR+lspphAVcsPphpEItcAs.cpLslpsh.lE.cKtaP+c.....atppGR....VtVphcp.........................sKpplhptlAphlpph+	...................slYPsYlssp+ohuE.G.RRlspph.......AVc.sPpspEIt-ss..ptl.....G......lssh...lE...sKtaP+-...............a.tttGR....V+Vpl+p.................................t.h..th.sKcplhhhlAphl.ph........................................................	1	106	190	274
+4504	PF00660	SRP1_TIP1		Seripauperin and TIP1 family	Bateman A	anon	Prosite	Family	\N	25.00	25.00	27.00	26.30	22.40	21.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.48	0.72	-4.21	14	386	2009-01-15 18:05:59	2003-04-07 12:59:11	12	3	42	0	177	280	0	99.90	47	50.10	CHANGED	hsulusAssps........plsELssllsDl+upLs-Yhuhtts.sosh...shPssllslh.th.uohTDDSaTThhoplsFstlophlTtlPWYSoRLh.....PslsusLussususu	.......................hsoLAtuD-cl........sl..l.ELsVaVoDI+AHLupYh.Fpuspso-....ThPs-lA-........As..a..s..h..s.sa.TTh..L..T..u...I....s.s..-QVT+hITuVPWYSoRLc....PAIouALupsGIho...................................	0	34	66	111
+4505	PF05022	SRP40_C		SRP40, C-terminal domain	Wood V, Bateman A	anon	Pfam-B_9034 (release 7.6)	Domain	This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein Swiss:P32583 and its homologues. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.	20.90	20.90	21.40	24.30	18.90	20.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.69	0.72	-3.48	35	306	2009-09-11 14:16:26	2003-04-07 12:59:11	7	10	256	0	204	294	1	71.00	45	13.93	CHANGED	s.FpRlc....hpclph.cpcLtDNoYtuts......ssaGcKAsccLthsRGKsFTKEKNKKKRGSY+G.GpIs.hussShKF	.....................FpRlc.....pc.l..p.....hc.scltDNoapupt.......ssaGc.....+AsccLthT+GKuFp+EKsKKKRG.....SYRG..G...sIs..hpsp.ShKF.......	2	74	119	170
+4506	PF04888	SseC		Secretion system effector C (SseC) like family 	Finn RD	anon	Pfam-B_5525 (release 7.6)	Family	SseC is a secreted protein that forms a complex together with SecB and SecD on the surface of Salmonella.  All these proteins are secreted by the type III secretion system [1]. Many mucosal pathogens use type III secretion systems for the injection of effector proteins into target cells.  SecB, SseC and SecD are inserted into the target cell membrane.  where they form a small pore or translocon [1,2]. In addition to SseC, this family includes the bacterial secreted proteins PopB, PepB, YopB and EspD which are thought to be directly involved in pore formation, and type III secretion system translocon.	29.00	29.00	29.20	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.14	0.70	-5.09	35	864	2009-09-11 03:00:25	2003-04-07 12:59:11	7	2	470	0	55	430	6	247.80	21	61.88	CHANGED	lhhthsplhuchtppphpsphpphpphppppp....pchp-hpcplccttcpu...ccApKs.Gl...huKIhGWlusllollsuAh.......hhlsusulGs.....suAhhlusss..suhlutustp.u..............shsuhluptl.spsLsshsh..tth..hsttlstu..lssslsshu.....sssssssushsspsAuc.husthsttht..hht.hhtthhphhtp..tp.........................hhs..........................ptlphss.ssplssslsp.....................Gusphssushpppuspt.A-hthtpst..hptlpshhcphh-phsp..hhcshpphhpthhphls..spusstsplspps	.......................h.hhhhtlhhpsttpphps.ht.hpthpcspp....tphpchppphpct.ctt.....ccs..p+...sh.....hutlhshlhshhsslhush..................sh.hhhhGh............shhhusth......shstsuh.t.h..................................................ht.lthth.......stslt.hhsh..t.h...............hs.tt.lssu...hstslt.ht...................hh.sstt.hhtthAtt.hspt...hs.p.h.p...........................................................................................................................................................t....shphssthtp......................................................uhsthtts.hptph.phhAp.th.phh...p.hpphhc..hcthtp.........p..tphhpth.p.hp....ut.thhhht..t..................................................	0	17	23	39
+4507	PF00474	SSF		Sodium:solute symporter family	Finn RD	anon	Prosite	Family	This family includes Swiss:P33413 which is not in the Prosite entry.  Membership of this family is supported by a significant blast score.	19.80	19.80	19.80	19.80	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.29	0.70	-5.83	10	13052	2012-10-03 01:44:59	2003-04-07 12:59:11	12	51	3717	6	4094	10595	8262	353.80	21	74.16	CHANGED	YaLAGRShssashGhSlsASshSuupFlGLuGsuhtSGluhuhauhstLlslhllhallushat.....psGslThP-YlptRFtu++.lllaLSuLuLLlhlshthouslluGAtLIcpslGlsYpsAlllluuhTslYTlhGGhhAVsaTDTlQullMlhGsllLhlhshhclG..Ghsshhp+hhsAsPph..sDh..........hs...ssuhp.h+sPlstsShWsuhshGhsGl........PHIltRshuuK.....cu+slhpGhlhuhshhlllhsGhluhhhashclAsssP....cssGsplssuNhAaPpLshcLhPshltGlhLAlhlAAlMSoLsulhluuSohFTcDlYppl++cutssEpclsthutlhsLllsulAllsulpsspts.lhhhlphAauhLuushusVlLLulFWcRsNppGAhhGhIlG	............................................................................................ahhuG+.sh.s..s.h.h...h..uhuhh.us....h...S.uhp.h.....l.G..h.s.u....h.s.......a..h...............G....h..s...h.......h.......h..h....s.....h..s............h....h..h..u.....h.h...l..h...h..h...l...h.s....h.ht.......................p.h..s...h...h....T.h..s.....-....hhp..t...R....a....t........s......p........h..............h.......p..h.............l.......u.....u.l......h.........h....l.........l...........h......h....h........h...h.....h.....s...............s.........t.....h.............h.....u.......s....u..........h..........h......h........p.....................h........h..........G..........l.............s...................h..............................h.......u..............l...............h.............l....h....s....h....l...h............h.....h............Y.s...h..h.....G...........G...hhu...s.........s...hs..D.hl...Q.....s.................h.....l....h...l..h..u........h..h....h........h...h..h....h........s........h.....h........t......h..G..............u...h....s....t....h.......h....p.....t...h..........t....h...t..s...........th..................................................................hp......s..s...........................................h............h......h....s...h.............h........s...h......h....h....G...h.h.s......................p.h.l...Rh.hssc..............sh.p.t.h..h.....p.....u.....h.....h.......h......s.....h.......h.......h.....h.....h.....h......h......h.....h....h............h.....h.....h.....s.....h.....h........s.......h....h.....h.....h.....................................................h..........................t...s....s.....p........h......h...h.........h.h.......h.............t........h........h.........s...............s.......h.........h.....h...G.........l....h...h..u....s.....h....h.....A...A.........h.....h.S..o..hs....u...l...s.s..u..osh...s....pD.......l......a.................t...t.......h.....h...........p...............p.....t...............................t.........s..............p..............p............p......h....h......h........h....u....+....h.......h....s.....l......h..........h....u....h....l....s........h....h....h...u.....h...................t....s.....................l...h.......h...h.............h...h...h.u........h.h.s.........us..h...hsh...h.l.h.u.l..a...a.p....+....h..s...t........GA.hhuhhhG................................................................................................................................................................................................................	1	1309	2409	3400
+4508	PF04686	SsgA		Streptomyces sporulation and cell division protein, SsgA	Mifsud W	anon	Pfam-B_5645 (release 7.5)	Family	The precise function of SsgA is unknown. It has been found to be essential for spore formation, and to stimulate cell division [1].	25.00	25.00	26.10	25.70	20.70	19.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.20	0.72	-4.33	27	307	2009-09-11 07:36:54	2003-04-07 12:59:11	7	1	100	3	119	297	0	99.20	41	68.34	CHANGED	sls..spLRY-ss.DPaAVplsF.psss..stsV.pWsFuR-LLt-Glp..pPsGpGDVRlhPs.tt..spshlhlpL...suPsG...pAllchssstltsFLcRT.thVPsGpEp	.....................lPspL+Y-ss....DP.aAV+hsF..+sss......stsV.pWsFuR-LLscGLp....pPsGpGDVRlhPs..t.......uts.tl.hl.pL......puPsG...pAllcsssssLtsFLcRT.plVP.GpE........	0	30	93	118
+4509	PF00720	SSI		Subtilisin inhibitor-like	Bateman A	anon	Pfam-B_679 (release 2.1)	Domain	\N	21.80	21.80	22.10	23.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.25	0.72	-4.06	22	154	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	96	4	53	172	1	89.80	34	64.64	CHANGED	YAPSALVLTlGpGpuAAoAsspRAVTLoCsPssuGTHPustuACApL+u..ssGDhstL...sspssthCT+pacPVsVTs-GVWpG+RVuaE+TFuNp	.................................hsh..s..s..sss..+uss....LsC...s...Ps...uGo.HPsstuACApLcs..s..s....G.c.h.ssl.....ssssthCThp.Y.s.P.Vss.sssGsWpG+tVsappsasN.........	0	20	44	53
+4510	PF04056	Ssl1		Ssl1-like	Wood V, Finn RD	anon	Pfam-B_13499 (release 7.3);	Family	Ssl1-like proteins are 40kDa subunits of the Transcription factor II H complex.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.20	0.71	-4.71	6	389	2012-10-10 16:07:06	2003-04-07 12:59:11	9	14	298	0	266	650	20	173.80	38	45.11	CHANGED	VlDsScuMp-pDh+PsRhshhlKhlptFlcEFFDQNPISQlGlIshKsthAc+lT-LoGNPcsHIcuLcoltp.pspG-sSLQNAL-hAptsLptlPuHsoREVLIlauSLoTsDPGDIapTI-sLK+ppIRsSVIGLSAEltlCKcLsppTs.G...tYuVlLDEsHh+-LLhcpssPPPuspsp..csoLI+MGFP	...........................llDhSpu.M...t.-.pD..h+....P.sRh.th..s.lph..h..........ptFlcEaF.-QNPISQlGlls..h+s..thApp.l.o..........-.............lo.....G......NPp....cHlpuL...........pph.......h.....p...........p..s...p......G....pPS..LQNuLchAh.........t.tL.....h.........p......h......P..u....+..s..o..R.E.............l..Ll.lh..u.u....L..s..osD.P.u...s........I.a..psI.ps..L.hp.ppIRlu..ll....GL...uA...plt...lCpplsppTs...G................pYtVhls-..pH..h+-.L.lhph.ssPP....ss..........t..........t.......tt.................tss........L...lh..M.GFP.......................................................................	1	99	149	221
+4511	PF04386	SspB		Stringent starvation protein B	Kerrison ND	anon	COG2969	Family	Escherichia coli stringent starvation protein B (SspB), is thought to enhance the specificity of degradation of tmRNA-tagged proteins by the ClpXP protease.  The tmRNA tag, also known as ssrA, is an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP.  SspB a cytoplasmic protein that specifically binds to residues 1-4 and 7 of the tag. Binding of SspB enhances degradation of tagged proteins by ClpX, and masks sequence elements important for ClpA interactions, inhibiting degradation by ClpA [1]. However, more recent work has cast doubt on the importance of SspB in wild-type cells [2]. SspB is encoded in an operon whose synthesis is stimulated by carbon, amino acid, and phosphate starvation.  SspB may play a special role during nutrient stress, for example by ensuring rapid degradation of the products of stalled translation, without causing a global increase in degradation of all ClpXP substrates [3].	20.00	20.00	20.00	20.20	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.74	0.71	-4.61	137	1666	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1653	33	367	1037	412	152.90	35	95.39	CHANGED	hs..sht.hhlRulhchl...........lssshp.aIshcsptsG..VplPpphh.c.sp.hhslhtcthtsLplss-t..hphshpFuGhPcplhlPhsAlhuhas.pssh.GhhF-spss.tt..............................................................ststtspsp...ttts.csshcVVp	...........................................h....spRPYLLRAhY-Wl..............lDNphTPa..llVcssh..PG..VpVPhcas.+DGpI..VLN.l...us+...As.s.sL..clsN-t....lpFsARFGG..lP+plhVPluAVlAIY.ARE..N..Gt.GhhF-....sEsshscsss......................................................t.tt.spp.........ssspsspt...s.tts+PsL+VVp....................................................................................................................................................................................................................................	2	87	197	277
+4512	PF03531	SSrecog		Structure-specific recognition protein (SSRP1)	Griffiths-Jones SR, Mistry J	anon	PRINTS	Domain	SSRP1 has been implicated in transcriptional initiation and elongation and in DNA replication and repair [1]. This domain belongs to the Pleckstrin homology fold superfamily.	25.00	25.00	25.30	26.10	24.80	21.10	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.46	0.70	-5.02	6	417	2012-10-04 00:02:25	2003-04-07 12:59:11	9	9	289	7	279	395	7	199.50	39	38.01	CHANGED	FsGFR-pDlscLtsFhpusauhshsEKpLsVpGWNWGpschtGshLoFslsS+sAFElPLosVSQs.lsGKNEVsLEFHpsDsutl......uLMEhRFHlPso.tpptsuD.......ssphFtcslhuhADV.suot-AlshFc-ItlLTPRGRYDIcla.TFl+L+GKTaDYKI.YoSllRLFLLP+pDpppsFFVlSLDPPIRQGQT+YsaLVhpFspDE-h-l	.................................sGFppp-hpplpphh.cp..tap..hpltp.+-hsl+GWNWGpschs............t.....s.......L.....sF.s.......lts.+.ss.FElPhu.plSp..s...h...sG...K.....N.EVslEF....p..............s-s...sts......................................pLhE.hRFalPss.........p.......p...t...ttD...............................s...sp...hFhpplhpKAc.lhp.s.sG-slshF..p-.l...hL..TPRGRYDIcha.s.h+L+GKTaDYKI.apslhRlFlLP+t..Dph..ph....hhVluLDPPl+QGQTRY.aLVh.Fpp-E-h..h.......................	0	104	161	234
+4513	PF04722	Ssu72		Ssu72-like protein	Waterfield DI, Finn RD, Mistry J, Wood V	anon	Pfam-B_5993 (release 7.5)	Family	The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB [1].  It binds to TFIIB and is also involved in mRNA elongation.  Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation.  Ssu72 is also essential for transcription termination of snRNAs [4][5].	25.00	25.00	27.00	37.90	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.33	0.71	-5.00	27	359	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	268	27	254	362	2	191.20	49	89.59	CHANGED	spL.+hssVCASNpNRSMEuHphLtc..uGa.sVpSaGTGStV+LPGsShD+PNVYpFG.TsYc-IYsDLhupcp.ch...YcpNGLLpMLcRN+clKtuPE+Wpc...................ssct...FDlllTCEERsaDsVl-DLhsRt........sphpcsVHVlNlDI+DspEpAhlGuptIL-Lsphlp....................tsspshE-pl.cllscapcca.phshLaslsaY	...................L+hssVCuSNpNRSMEAHphLpc...........p.Ga.sVpSFGTGotV+LPGPuhccPNVYsFs.ToYcphYsDLhp..KDt..cL....YppNGlLpML-RN++lK.sPERaQc.........................sp-h.....FDlllTCEERsaDtVl-DL.sRt...............pphspPVHVINlDIpDNcE.EAtlGuhhIh-Lsptlp.......................tspsh-scls-lLtcapc+p.phshLaolsaY....................	0	79	124	185
+4514	PF04184	ST7		ST7 protein	Bateman A	anon	Pfam-B_2088 (release 7.3)	Family	The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.	19.10	19.10	21.70	19.50	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	540	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.86	0.70	-6.27	5	405	2012-10-11 20:00:59	2003-04-07 12:59:11	7	7	139	0	132	319	4	378.60	62	93.97	CHANGED	luWSWTYLWslWFAlVlhLlYlLRuPLKLpEsLsuVol..FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLlGGVDNoussuS..Sss-stpNRQNVuECKVWRNPLNLFRGAEYSRYpWVTG+EPLTYYDMNLSAQDHQTFFTCDoDpL..RPuDoIMQKAWRERNPQARIpAAapALElN......................P-CATAYVLLAEEEATTIoEAE+LFKQALKAu-shhR..pupphpupupph-A.+RRDTNVlVYIKRRLAMCARKLGRlREAVKMMRDLMKEFPLLSMLNIHENLLEALLELQAYADVQAVLAKYD........DISLPKSATICYTAALLKARAVSDKF..SPEuAuRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYAFFHLQHWKRlEGALNLLHCTWEGTFRhIPYPLEKGHLFYPYPuCTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFoAMLALLTHQFPELMGVFAKAslsllhusht..h.chcsahPusIhppLsst	...........................................................................................oh................FLsoLTPKFYVALT.GTSSLISGLIh.I.FEWWYF+KaGTSFIEQVSl.....s.......Hlp...P.hhGG........s-.ss.s..p.s.........s...sp..s.......................t.....................t..s............ps.s.ppsls...ECKVWRNPLNLFRGAEYp..RapWsTG.+.EPLTYYDMNLSAQDHQT.FF.TC-oDth.....R.PuD.slMQ+AWRERNP.ARIpAAapALElN...........................cCAsAYlLLAEEEATTIs-AE+LFKQ..ALKAG-shYR..pSQph..Q...Hpu.staEu...hRRD.TNVLlYIK..R..R..LAMCAR..+LGRh+EAVKhMRDLhKEa.P...hshhN..IHENLlEuLLElQAYADVQAVLAK.Y.D....................................D..ISLPKSAsICYTA.ALL.KsRsV.uDKF..SPEsAS+RGLSoAEhs..AVEAIHRAVEFNPHVP.KYLLEMKuL..I.LP.PEHILKRG.D.SEAlAYAFFHLtHWKRlEGALNLLpCTWEG.T.....FRhlPaPLE+GHLFYPYP.CTEsADRELLPs.FHcVSVYPKKELPhFIhFTAGlCS.TAhlAlL..THQaPE.MGlhA+s...h..h..........................h..............................................................................................................................................	0	33	46	86
+4515	PF03298	Stanniocalcin		Stanniocalcin family	Mifsud W	anon	Pfam-B_4401 (release 6.5)	Family	\N	20.70	20.70	20.90	20.90	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.69	0.70	-5.32	16	167	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	69	0	77	133	0	193.90	45	78.10	CHANGED	Mlh+suL..LllhlLssuu.......aEss.--s..usR+uRhSsposu-VsRCLsuALpVGCGsFuCLENSTCDTDGMH-ICpoFLaoAAKFDTQGKoFVKESLKChAsGloSKhFhslRRCooFQcMluEVQcECYsKLDLCoVA+pNPpAIsEVlQlPspFPNRaYspLLpSLLsCDEETVssVRsSlhu+lGPshusLFplLQsssssssussu	.............................................................sh..llhhshs.st..........Es..pcu..u.p+u.RhuhpsoA-l.+CLssAhp..V.G..CGsF.tChE.N.s.o.C-hcG..h.....a.....-.....IChoFLasAuKFDsQGKuFlK-uL.KChA.p...ulp.pKhh.th..R+CsshpcMlhp...lQcECY.Kh..slCus...A+cNscsIsEhlph.shFs...p.c.YscLlp.LLpCsE-shpslpcSl.tpht.shuuLhplLphspss.tp..s.................................	0	17	25	43
+4516	PF02200	STE		STE like transcription factor	SMART	anon	Alignment kindly provided by SMART	Family	\N	25.00	25.00	47.60	47.60	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.51	0.72	-3.91	8	177	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	156	0	105	177	0	104.80	74	16.69	CHANGED	sQlIRRahLssG-.YlSCVhWNsLaaITGTDIVRsllaRFpsFGRslpspKKFEEGIFSDLRNLKsGsDAoLEpPKSPFL-FLY+NuCIRTQKKQKVFYWFSVPHD+LFsD	....................s.QhIRRFhLPoG-.aVSCVhWNNLaHIoGTDIVRCLsFRFQAFGRPV+NpKKFEEGIFSDLRNLKsGoDAoLEEPKSsFLDFLaKNsCIRTQKKQ...KVFYWaSVPHDRLFLD........	0	29	61	92
+4517	PF02876	Stap_Strp_tox_C		Staphylococcal/Streptococcal toxin, beta-grasp domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	\N	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.47	0.72	-3.88	41	3442	2012-10-01 21:38:54	2003-04-07 12:59:11	12	3	194	211	29	1049	1	99.20	31	42.23	CHANGED	+......pls.lslahcspppph....spplpssKcpVTlQELDhKlR+aLh..ccapLY.................sushppGhItaphss..sppasaDLa.h.s......pchLphYpDNKslcScpl.+I-VhLp	............................hh.sttp.t......tp.hphsKcploLKELDaKlRchLl..cpapLY.................pushppGpIplphcs..sspashDL...........sccLphpc.scslcuppltcI-V.l....................	1	16	24	28
+4518	PF01123	Stap_Strp_toxin		Staphylococcal/Streptococcal toxin, OB-fold domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Prosite	Family	\N	20.70	20.70	20.80	20.90	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.10	0.72	-3.50	22	1277	2009-01-15 18:05:59	2003-04-07 12:59:11	15	2	190	179	10	523	0	85.50	32	37.19	CHANGED	NlpphYtshshsttp..thposcphlppsLlapsps.........pslpsEhsspphsppa.KsKpVDlaGl.YthpCht.t............hstshYGGVT.p	.........................NlpphYtp.phpphp..shpsscphLspsLlFps.t.........pslpsEFpspshusca.KsKpVDlaGlsYthpChh.t.............tspChYGGVTh................	3	1	8	9
+4519	PF04022	Staphylcoagulse		Staphylocoagulase repeat	Bateman A	anon	Prosite	Repeat	\N	19.70	19.70	20.20	26.20	18.90	16.60	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.17	0.72	-4.58	22	1401	2009-01-15 18:05:59	2003-04-07 12:59:11	7	18	155	0	5	881	0	26.90	84	26.32	CHANGED	RPTaNKPSETNAYNVTTHAsGpVSYGA	..RPT.NKPSETNAYNVTTHANGQVSYGA..	0	5	5	5
+4520	PF02821	Staphylokinase		Staphylokinase/Streptokinase family	Bateman A, Griffiths-Jones SR	anon	PDB	Domain	\N	21.70	21.70	21.90	31.20	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.29	0.71	-4.33	11	458	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	171	31	11	340	0	122.40	32	79.68	CHANGED	sstppsssshplphtspssDhchp.hlhs....hphtsschloppElttthpphlsp.sp.satlhppc.shhtcssshpt.p.hspcpphshhIss+ptthshsscsuhp.hhs...ptc.l.pchhlhcc	............................uph.sss.hl.hsspssDschs.lLpsphh.hsltsGsoLTppclthhspahLst.sa.-atlhEpDsShhhcssshh+.h.hsp-pphoahIp-+ttshstsscsshp.thN...pp..l.pKhhl.KK...................................	0	1	4	7
+4521	PF01017	STAT_alpha	STAT; 	STAT protein, all-alpha domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_856 (release 3.0)	Family	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.	27.50	27.50	27.70	27.70	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.10	0.71	-4.56	26	626	2009-01-15 18:05:59	2003-04-07 12:59:11	15	30	117	9	231	569	0	170.90	31	24.35	CHANGED	h-+Qppl-s+lppl+spsp.cs-psl+tLcchQ................-pasapap.......olpshtchp...hNs.t.ct.hppcphhlpphhp........pLphpRppllpchppllshlcplppslls-EL.-WK+RQQhACIGGP.s.pssLDQLQsWhTtlAEsLhQlRQQLK+lp-LppplsYssDPlspt+spLppplppLlpsLlpS	....................................................................................................pcp.plppplppl+thsp.ph-pch+tLp.....p..hQ...................-.aphpap..............plp....s......ht.php...............pt....s...p.........hpp.c....t....l.pphhp............tLp.phR...t..pllp.c....hp..p....hlshhcthQ....ptlls-ELhpWKRRQQlAs..GGP..s...ps...sLD..pLQsW...hptLAE.lhQhRQ....Ql++hcc.Lpp.p..h.shp.s.pP..ls.pths.L...ptplsplhpsLlpS............................................	0	34	51	117
+4522	PF02864	STAT_bind		STAT protein, DNA binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_856 (release 3.0)	Domain	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. This family represents the DNA binding domain of STAT, which has an ig-like fold. STAT proteins also include an SH2 domain Pfam:PF00017.	20.20	20.20	20.40	21.90	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.80	0.70	-4.78	9	708	2012-10-03 00:25:27	2003-04-07 12:59:11	10	35	125	9	273	620	4	217.30	41	33.61	CHANGED	FlVE+QPCMP.pPpRPLVLKTtspFTs+lRLLV+h.ELNhplKscslhD+pss-hts.ch.......R+FNlhGoso.KlhNhEco.ssSLus-FpaLph+E.+stsusRsNpcGshhVTEELHslsFEophshtG..LpIcLcThSLPVVVISNssQhPsAWASILWaNhhosps+N.sFFssPPtusWsQLuEsLSWQFSSpst..RGLs.-QLshLA-KLhspsus.....sstploWscFCKEphss+uFoFWhWl-uIlDLlK+	................................................................FllE+QP........P.Vl.KT.tspFss.pl..RL........LVth.cLNh..phps..s.h...s.....p..hs-.ts..th..................+p...s...h.h.......s......pso..cl....hN.pps...php....ssphhph...ph+..p...pht....t...htR.s...s....c...Gs........VT..EEhaslhF.pop.hshtu...........L....hhp......l......c......ThSLPV.VVIspss.Q.ssAhAolLW.Nhh.s.p.s..+.........s.FssPsts.WsQlsEsLs..hpFpu...st..........RGLs.-pLshLupKLh....s.ssst...........ssh.loWu.pF...sK..................E.s..........l.s.s..+......sF...oFW.Wh-ull-LlK+...............................	0	45	65	143
+4523	PF02865	STAT_int	STAT_prot; 	STAT protein, protein interaction domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_856 (release 3.0)	Domain	STAT proteins (Signal Transducers and Activators of Transcription) are a family of transcription factors that are specifically activated to regulate gene transcription when cells encounter cytokines and growth factors. STAT proteins also include an SH2 domain Pfam:PF00017.	26.00	26.00	29.50	26.40	25.30	25.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.69	0.71	-4.16	22	576	2009-01-15 18:05:59	2003-04-07 12:59:11	12	26	102	3	210	502	0	117.70	39	16.63	CHANGED	o.WtplQpLpschL-Q.lppLYsssF.PhElRpaLApWIEs..QsW-ths......s-shAshlhpsLlppLpcphpphspp.sshLhphplpcht.pplpsha.ppsPhplsthlpphLppEp+llppApps	...........utWhplQQ.LpschLcQ.lppLY.s.c.p.F.PhE...lRpaLApWIEs...Qs.W-ths.........cpshAohlhcsLl....ppLppphs+.......hs....tE.sshLlphplt+ht.ppL..Q..spa.pcsPhplsthIpphLhpEp+llppApps......................................	0	29	43	96
+4524	PF03875	Statherin		Statherin	Finn RD	anon	DOMO:DM07003;	Family	Statherin functions biologically to inhibit the  nucleation and growth of calcium phosphate minerals. The N-terminus of statherin is highly charge, the glutamic acids of which  have been shown to be  important in the recognition hydroxyapatite [1]. 	25.00	25.00	29.20	35.40	16.70	16.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.24	0.72	-4.08	2	11	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	8	0	1	8	0	39.40	74	68.08	CHANGED	DSSEEKFLRRltRFs.G.YGPYQPhs..PLYPQPYQP...QY	....DSSEE.KFLRRltRas.G.YGPYQPhPEQPLYPQPYQP.YQQY	0	1	1	1
+4525	PF00836	Stathmin		Stathmin family	Bateman A, Mistry J, Segerman B	anon	Pfam-B_1551 (release 2.1)	Family	The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton.  They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerisation of tubulin heterodimers [1].	20.40	20.40	20.40	20.60	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-11.03	0.71	-4.55	4	392	2009-01-15 18:05:59	2003-04-07 12:59:11	14	5	92	15	157	297	5	129.70	55	68.99	CHANGED	SDhcVKpLpKRASGQAFELILpPPSh-usP-hslosPKKKDhSLEEIQKKLEAAEERRK.pEAElLKQLAEKREHE+EVLQKAIEENNNFSKMAEEKLspKMEs.KENREAplAAhLERLpEKDKHsEEVRKNKEhK-.u	.......................................DhpVKplpKRASGQ.uFElILp.PPS...............u...s..........hsho.s.P....+.+.KD..hSL.E..EIQKKLEAAEERRK..op...EAplLKpLAE.KREHE+EV..lpK.A..lEE.NNNFsKhAcE...KLp.KM.......EtsKE.NREAplAAhhERL.pEK-c+h.tEVR+sKE.p..................................	0	26	39	74
+4526	PF02116	STE2		Fungal pheromone mating factor STE2 GPCR	Mian N, Bateman A	anon	IPR000366	Family	\N	26.20	26.20	26.30	26.20	25.50	26.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.94	0.70	-5.37	19	170	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	139	1	88	160	0	273.90	32	65.70	CHANGED	asPhpphlsapts....G.sshslshsplsphlppplphuIhaGsplGAs.llhlllLhhlo+sc....+oslFllNpsuLhhshl+usL.htYhhusasul.hhhTu.hphlopsshtspsAuslhpslLlssIEhSLlhQlpVlaps.s.+hhthhLhulSshlulssluhhhssslpshh....slhssssst.shhah.....slssIlhusSIsFhohlLlsKLhhAI+pRRhLGL+QFsuh+ILhIMusQTlllPS...........ILhIlpY..hssh..spLssluhhLVsLSLPLSSlWAu	..............sPhpQslshhts.....G..s.hsl....shstl-shhp.tlphsIsausplGAs.hlhL.llhh.h.hopscc..h..........+s.lFllNhluLhlsllRssLhhhahho.sass....hhhhaoGsa..ph...lstu.shpsSlAusllplllsshlEsSLhhQshlhhps..hs....phh+..hhlsslShllulssluhphssslhpsh..................slhp....s..ss....hs.....hh.Wl..................phshIlhssSIsaaohlhssKLlh.A.lhoR...R.hL..Gh.Kp.F.suhclLlIMusQohllPu............lhslLpa.h.ss....s.phsolshslVllsLPLSSlWAt..................................................	0	14	42	72
+4527	PF02076	STE3		Pheromone A receptor	Mian N, Bateman A	anon	IPR001499	Family	\N	24.90	24.90	25.50	26.70	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.92	0.70	-5.32	50	604	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	245	0	180	590	1	238.10	28	69.11	CHANGED	sshuhluhlLslhPLsWHh+u+NsushhlhhWhhlssLpphlNullWssss.ts.hhs..saCDIss+lhlGuslulPuuslCIs+pLtpIhsscpsphstspp..p+plhhDlhlslhhPllhMuLpalVQuaRasIhcthGChsshhsohsuhhlhahWslllulluslYusLsLhtFh++RtQFsslLpsspSuLohuRahRLhhLuhl.hlhhhPlshaslh..lphppss....hsa.SWspsHss...a.spI.paP.............hsplhhsRWlssssuhlhFhhFG....hup-........AhphY	.............................h..hh....h.hhh.st..s.ush...hhhhWhhlhsl.thlNullW.sss..hs.hhP...sWCDI..s..........s+.lhhus.slG.lssush..CIsRpLt.p.Iss....s.ct.s.t.hotpc+................+Rp..hhhDhhlslGlPllhhsL.......phllQspRasIhcthGChsshh.ohsshhlhhhWs.hlhuhsuslYus...lslhhhhp+..Rtph.pphlts.s....Ss.l..s..h.s.Ra..h....R....Lhhhshh.lhh.hhPhshh.hh..h.............a.sat.hH........h..t...l..hs..................h........h....h.shhhh.hhFu.hs.-s...Y........................................	0	99	134	164
+4529	PF04885	Stig1		Stigma-specific protein, Stig1	Mifsud W	anon	Pfam-B_6528 (release 7.6)	Family	This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone [1].	21.90	21.90	22.00	21.90	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.49	0.71	-12.08	0.71	-3.97	14	196	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	43	0	144	189	4	94.50	32	43.63	CHANGED	llhlllslslphhshsssssss............p..tppspssshhssspss..ssh..ut....................pCsp..sstICpsst.....ssphsCCpN.+CVDltosctNCGsCsptCca.up.pCCsG.CVslthDpppCGpCsppCt.Gp.CsaGhCsYA	..............................................................................................hh.........................................................................................................................................sC.....t...........C.hsh........s..pCGhCsp.tC.ph.u.p.pCC..sGt.C...Vs...ltsD.ppCGtCsp..........tCstGphChhGhCs..............	0	50	108	135
+4530	PF05217	STOP		STOP protein	Moxon SJ	anon	Pfam-B_6629 (release 7.7)	Family	Neurons contain abundant subsets of highly stable microtubules that resist de-polymerising conditions such as exposure to the cold. Stable  microtubules are thought to be essential for neuronal development, maintenance, and function. STOP is a major factor responsible for the  intriguing stability properties of neuronal microtubules and is important  for synaptic plasticity. Additionally knowledge of STOPs function and properties may help in the treatment of neuroleptics in illnesses such as schizophrenia, currently thought to result from synaptic defects [1].	27.00	27.00	27.20	27.20	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.79	0.70	-4.60	20	445	2009-01-15 18:05:59	2003-04-07 12:59:11	7	11	81	0	305	392	1	156.10	15	61.31	CHANGED	ut..ClCplCsCu+p..hCp..ppslplslshphh.......SsYcp-a............sspssptss.hsttchps+thsl....................osYppDFphhsh........stpccsh.tpshshsupouYsosa.shss.ssspht.sp.hsshs..hshsspToY+p-Fp.shpt.....sshsscsp.tpthss.....a.s.o............appsapspssssht..................................thppchshssos.Fpuph..........pphca	.........................................................t.....................................................................othtpp............................................................................................................................................osh+.pDatsapht.....t.hp..p.p.p.h.t..sss.s..F.pstTo...a......ppcahs..h...th........h.....t...sh.+s.t......h....s...hPhp.s.o............sa+.pah..s....................................................................................................................................................................................................	0	134	160	207
+4531	PF03088	Str_synth		Strictosidine synthase	Griffiths-Jones SR	anon	Pfam-B_1533 (release 6.5)	Family	Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid  biosynthesis.  It catalyses the condensation of tryptamine with  secologanin to form strictosidine.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.69	0.72	-3.95	8	707	2012-10-05 17:30:42	2003-04-07 12:59:11	11	11	260	14	391	1067	163	85.90	36	22.65	CHANGED	sulsVssp.GVlYFTDuSo+Ysh.+plhhshLpGcssGRLh+aDPoT+sT+VLLccLaFsNGlulSsDpoallhsEsshpphh+Yalpts	.............................................sslslsps.GplYFTDo.........S.........s...........c..........aph....c..............p.......a........h....hsh...........h..p...u.......c.s.sG..R.Ll+YD...............s.p..T.pps.pVL.lcs.Lt.FsNGVulSsDpsa.......ll....lsETsttR.lh+YalpG....................	1	98	227	319
+4532	PF04270	Strep_his_triad	strep_his_triad; 	Streptococcal histidine triad protein 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	All members of this family are proteins from Streptococcal species.  The proteins are characterised by having a HxxHxH motif that usually occurs multiple times throughout the protein.	20.90	20.90	21.30	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.58	0.72	-4.24	5	2985	2009-01-15 18:05:59	2003-04-07 12:59:11	8	20	316	3	93	1739	0	48.40	47	18.71	CHANGED	YTT-DGYIFsPsDII-DpGDAYlVPHGsHYHYIPKc-LSsSELAAAQAYhupK	..........sDGYlFs.PscIlp-.s....u.....s.ualVPH..G..sHaHaIPKspLSt..E.hthAp...................................	0	21	31	53
+4533	PF02516	STT3		Oligosaccharyl transferase STT3 subunit	Bashton M, Bateman A	anon	Pfam-B_1095 (release 5.4)	Family	This family consists of the oligosaccharyl transferase STT3 subunit and related proteins.  The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for its activity [2].  In eukaryotes, OTase transfers a lipid-linked core-oligosaccharide to selected asparagine residues in the ER [2]. In the archaea STT3 occurs alone, rather than in an OTase complex, and is required for N-glycosylation of asparagines [3-4].	27.90	27.90	27.90	28.10	26.90	27.70	hmmbuild  -o /dev/null HMM SEED	483	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.93	0.70	-5.53	15	968	2012-10-03 03:08:05	2003-04-07 12:59:11	9	12	617	11	541	870	126	459.70	26	63.95	CHANGED	hltlllhuhhhhssshuc.........lFsstphhshh.-hDsYYpaRlsctllpcGa........hsthsaa.pptaYPhG.hlsassllshL.hshhsllhhhhs......hslpplshhhsPlluulsuIssahLs..+clpsctsGlluAhlluluPu.YlsRoluGha..Ds-hhslhlhhhshhhalcuh+sus............hhassluuLshhlhshuWsGh..........lhhhshhsLhllshLlhu+..........apschhhlh...............shshllssls..hl.hshlGat.........hhthhhlhulhphhshsshstt............hhshhpats.....lhhsu.lsplsslh..ssslhsluhhGhlu.h..................sGhhaslhp..........hschpl.hls.ls.apshuhhuhhhul+Fh.lhshPlsl...hasshhlcshtshhhhhu.....................hhthhhssshsh.lhlslssslshlushths.tlhsphhtpttsth+h.....t..........................................ssssssllhstasashhhhshtsp.....Vshsuhu	.....................................................................h...h..h.hhhhh...h....h...............hhs..h..h.h...a..........h..hp....EF.DPa.F..paR.tsphlspp..Ga................athhsaFD.t..............saaP...hG...h..l..h..h..G.....o..h..h....s.s..L......h...h..ssth..lh.h.hhp.................hpl.t.s.ls..l..a....h..ush.huu.lss.l.s.sa...hls.....cch.................t......s........s...........t........u........G....l...lAAhhhul.sP...............u.YlsRSh.uG.a..Ds-sl..s.I...h...h...h.h...h.s..h...a...h.a..l...+.ulcpss.................................................hh.a..u..shs..uLshh...h.h..l.u..W.uGa..........................sallsll.s..L..a.shhh.l...l..h.tR...................................................................hsp..pla...huh.................................shh.hhl...shlh.......s.ht..l..sFlu...Ftshp.........s.pth..u.........s..hu...l..h.sl.l...t..l..h..h....h..hthh.t................................tlshttaps.........................lhhhh.....hhh.shhhh........hhslhhls..h.h..uh..lu..s.h..............................................................................................................suhh.hSLhs...............sasp.h...p.h.shh.s.sls.at...s.s..s.......a.uh..hhs...lp..hh....l....hhhP.s.ul..........hhs..h....h...h.......p...........t....p...l.hl.hhhu........................................................................hhs..hhhsssh.l.h..lh..Ls....L..sP..s.....h...s.h...h.....u..u....hshs.....p...........lhs......p...h.....h.t...t.....t...p.......................................................................................................................................................................................................................................................t.s.......ps.h............lh.s.hhshhh..hhhhtsph....shsp...................................................................................................................................................................................................................................................	0	184	311	447
+4534	PF03481	SUA5		Putative GTP-binding controlling metal-binding	Bateman A	anon	Bateman A	Domain	Structural investigation of this domain suggests that it might be a GTP-binding region that regulates metal binding and involves hydrolysis of ATP to AMP. It is found to the C-terminus of Pfam:PF01300.	22.90	22.90	23.00	23.20	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-11.20	0.71	-4.04	384	2044	2012-10-03 16:42:30	2003-04-07 12:59:11	8	11	2016	4	615	1629	1172	136.70	28	39.29	CHANGED	lohEp..lc..pllGt...........h........t..t......t....sp..tP.........p.APGMhhpHYAPputl........h..ls........p.................th...pt.............................................sptlhhlshst......................................htt...........s................hsh...........usptchppsApsLFssLRphDp...........p......sh.chIhsp........s..hs.p....p...Gl..G.tAIhsRLp+A.Au	............................................lTh-plcpllGp.......................th.h........pc..............sp...tP.c.APGMKYpHYAPc.sslhll..p.....................sh....t........p..............................................................spclullshpph................................................................................htth......t..........hhh........h...........ustschpp.sApsLassLRphDc..............p....sl.chI..hsp........................s.hs....p...s.....sl.G...tAlhNRLpKAAu............................	0	225	402	517
+4535	PF01300	Sua5_yciO_yrdC		Telomere recombination	Finn RD, Bateman A	anon	Prosite	Family	This domain has been shown to bind preferentially to dsRNA [1]. The domain is found in SUA5 Swiss:P32579 as well as HypF and YrdC Swiss:P45748. It has also been shown to be required for telomere recombniation in yeast.	22.80	22.80	22.80	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.11	0.71	-5.03	163	8425	2009-01-15 18:05:59	2003-04-07 12:59:11	13	39	4856	15	2171	6104	3104	175.00	27	51.50	CHANGED	phLcpGtllAhPT-osYuLuscst.sppAlp+lhphKpRs..sK..Plslhss.....slpp..lpphst...th.......spthhp............hhpp....hhPGPlTllhph..................pp.......lsp..hl.............sstsslGlRlPspsltttLhc..................th.t.....s...........lluTSANhSG.c...sss.tsspclhpp.l....sstlD.......hllcss........hh.tshsSTll..c.lh......t.p......l.lRpG	........................................t.hlppGtlluhPT-os.YuL..u.......scst..........s...........p.......pA..........l..........p+lhphKp.R.P..t.........s+.........slhlhss........shpp..l.pp.asp......h..........................s.s.t.h.hc.....................................lh..ps.....h.......h....P.......G...PlTh..lltt.....................................tpp......lsp...hl...................ss.s.h.so....lulR....l.....Psp.P..lshtLlp.........................................................th.u.t...P...................lsuo..SA.N....l.S.G.p............ss.s....p..s....s.p......c...l.hpc...L..........s.s..p..l.c......................h.l.l.cu.......s............ht.......t......t..........h.s........STll..Dhs.......st.st.....l.lRtG.........................................................	0	706	1382	1838
+4536	PF00862	Sucrose_synth		Sucrose synthase	Bateman A	anon	Pfam-B_484 (release 3.0)	Family	Sucrose synthases catalyse the synthesis of sucrose from UDP-glucose and fructose. This family includes the bulk of the sucrose synthase protein.  However the carboxyl terminal region of the sucrose synthases belongs to the glycosyl transferase family Pfam:PF00534.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	550	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.61	0.70	-6.54	4	604	2012-10-03 16:42:30	2003-04-07 12:59:11	14	9	221	27	131	815	109	398.90	57	63.47	CHANGED	TRVHSlRERls-TLoAHRNElLuLLSRh.upGKGILQPHQLlsEaEsI..tED+tKLcD..GsFu-Vl+SsQEAIVlPPWVALAlRPRPGVWEYVRVNVacLsVEELoVsEYLpFKEELV-GSSsuNFlLELDFEPFNASFPRPTLoKSIGNGVQFLNRHLSuKhFHsK-ShaPLL-FLRlHsYpG+oLMLNDRIQslsuLQusLRKA--YLuoLPsDTPYSEFEH+FQElGhERGWGDsAcRVhE.hHLLLDLLEAPDPsTLETFLG+IPMVFNVVILSPHGYFAQsNVLGYPDTGGQVVYILDQVRALEsEMLhRIKpQGLDIsPRILIVTRLLPDAVGTTCsQRLEKVhGTEHoHILRVPFRTEKGILRKWISRFEVWPYLETasEDVApElAtELQupPDLIIGNYSDGNLVASLLAHKLGVTQCTIAHALEKTKYP-SDIYWKKFEc+YHFSCQFTADLIAMNHsDFIITSTFQEIAGSKDTVGQYESHTAFTLPGLYRVVHGIDVFDPKFNIVSPGADhoIYFPYoEpEKRLTuLHPEIEELLYS	..............................................................................................................................h...h.........................h..hh...pEhhh.s..hhhhhR..p.u..phhplp..th.h-.h...ph.Lth+-thh.t.........p....t....L.El..DFtsFp..hPp.p.sp.IGpGhpals+ahou.hh..t...p...p......h....Lhta.L..hph......p...G........hhls.pp.lps..tLp..lhhA..hl.th..ppsatpht.p........hpthGhE.GWGssAt+s.p.hphL.-llpuP-.s.shEtFhuplPhhF.....plVlhSsHGaF.u..Q..ts..V.L..Gh.PDTGGQ........VVYILDQVRAL.Ep.E.h.l.R...l.....c.......Q..GL.....s...l.....h.P+I....l.....l...l....T.R.L.l.P.-..A..h...GT..s..C..s......Q..+..L..E..cl........G..o...c.......t..s.pIL.RVPF+s.pp.G.h.lcpWISRF-.lWPYLE.p.as...c.............D...........s...........s...........t..........E....l...........h.......t...........Eh...........p......u...........p...........P.D...L..I.lGNYSDGNlVAoLLup+LsVTp.........C.......sIAHAL...EK...T...K...YP.......c....SDI...Y....W+...c....h...--KYHFSCQFTADLhAMNpoDFIITSTaQEIAGSK-oVGQYESHtAFTL..P.G.L.Y.RVV.HGIDVFDPKFNIVSPGAD.slYFPYT-pc.c.RLTshHscIEELLas...........................................................	0	25	79	113
+4537	PF02657	SufE	UPF0050;	Fe-S metabolism associated domain	Bashton M, Bateman A	anon	COG2166	Family	This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export [1]).	20.20	20.20	20.20	20.40	20.10	19.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.31	0.71	-4.49	7	2432	2012-10-01 20:52:23	2003-04-07 12:59:11	10	5	1792	5	531	1474	985	125.00	36	81.81	CHANGED	lhppF.cstph-c+Yc.LlphGppLsshscchhtptp..l.GCpSplal.htshpssth..hF.u.o-AhlspGlhullhphhsGpTss-Ilshssh.FFpcLult.pLS.uR.pGhpulhtthpphsh	.........................................hpsFt.hssWE-+YchlIpLGcpLP.sLs..-...c...h..+...s...p...t...pp...l...pGCpSp.V..Wl............h....h.....p......p....s.........p....s.......G........p...l........cF..p.....G..D..SD..A.t...IV+.........GLlAlllt...hh........sG.pTsp-lhshc...s....p.sa.Fccl..GL...p.p.p.L...S..PoRopGLpAhlctI+stA.t...............................	1	147	317	440
+4538	PF05076	SUFU		Suppressor of fused protein (SUFU)	Moxon SJ	anon	Pfam-B_6089 (release 7.7)	Family	SUFU, encoding the human orthologue of Drosophila suppressor of fused,  appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus [1]. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway [2]. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems [3]. 	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-11.15	0.71	-4.68	132	954	2009-09-17 14:43:38	2003-04-07 12:59:11	8	30	737	5	252	788	16	163.50	19	53.36	CHANGED	ts.ssh.slslhhhts..t.......pshhphlThGhS..............................th.ht..sp........phhthELhhtl.................spp.hashphLt...........slA.phshp....pss...h..l....s.Gphl..................s..psht....tso.....phsuhhlhts......hhtssphsth.............stt.......lpahpllPlppsEhpahp....ppG...scsL.hpth..tpt.....shtlhDhpRps	............................................................................................................s.......lslhth.s.............shhpasThGho.................................th.ht....tt.......t.pththELhhtl...................ptt..hhhp.hLt...........slA..phshp....ptp..h...h..............s.Gphl..........................s..pshs........tss...phsthlhs.s......hhtssp.h.sth...................stt................Vpal.llPlsppEhphhp.......ppG........hps..l..hchh..ppt.....shplhDhpR.........................................	0	80	153	211
+4539	PF04198	Sugar-bind		Putative sugar-binding domain	Bateman A	anon	Pfam-B_1085 (release 7.3)	Domain	This probable domain is found in bacterial transcriptional regulators such as DeoR and SorC. These proteins have an amino-terminal helix-turn-helix Pfam:PF00325 that binds to DNA. This domain is probably the ligand regulator binding region.  SorC is regulated by sorbose and other members of this family are likely to be regulated by other sugar substrates.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.22	0.70	-5.48	31	3935	2012-10-04 00:26:15	2003-04-07 12:59:11	8	27	2304	24	585	2201	210	247.90	26	76.87	CHANGED	sphssshcLEptLcc+auLccshVV..Psss.....st..sss.hpplutsuuphlpp.hlp.ssp..lluluhGcTltssscthss..hphpslphVshhGGhst...hs.hps...lstphAc+h.supsthh.sPshhsssphtcslhpptslpsllphhcpsDlslhGIGshtp..puthhtpshhspp-hppl.pptuuVG-lhGt.aFDtpGphlp.tshss+slulpl-pL+phsphlulAuGppKspAIhAAL+us.hls.sLlTDEpoAptlLs	.....................................................t.hplEppLpc+a...u.LpcshV..l.......s..sps.................sp.....tsh..tpplup.suAphLpp..hlp...ssp..........llul.u.aGp.T.......ltsls..c.p.l....ss.........h.....p.h..p..p..l..p....h.....Vsh........t.......G.......Gh......u......p......tht...hp.ss..p.ls.tphApph..su.p.s.p.hl.sPhh.hsssp.......htpslh.pcpslpplh.phhpp.....uclulhGIGshtp.....puth.h....ps.h.h.s.p.....p-.h.......p.p.l.tppsAVG.-lhuh.FaDtcGphlp...thpp+...slGlsL.pp.Lc..........p..........h.....sph.lulA..uGppK.s.pAIh.............uuL+....us..hls..sLlTDpssAptlL.............................	0	153	343	458
+4540	PF00083	Sugar_tr	sugar_tr; 	Sugar (and other) transporter	Sonnhammer ELL	anon	Prosite hmmls-iteration	Family	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.46	0.70	-5.91	44	32448	2012-10-03 03:33:39	2003-04-07 12:59:11	19	163	3323	0	14571	74553	5580	356.20	18	81.17	CHANGED	hshhsuhuG.hhFGaDsGhIuuhhthhshhhpas.htpppssth.................................................................p.h.ulhVuhh.lGshlGulhsuhhuctaGR+.hullh.ssllhllGsllpshup..........shhhlhlG........RllhGlulGhhsshsPhaluElA...PpplR.GslsshhQLhl.shGIhluhhhshsh.tthss.........tW+l.lulshl.ulhhhhsh.halPESPRaL.l.psch-.cAcpsLt+...hpt.....t.ss.pltc.hsphpts.t.t......hshtplhpths...hh..lhhuhhlphhQQhoGhNslhYYusslFpslGhsss...hhsolllG.llNhshThlu.l...ahl-+hGRR.......phhLhG.......hsshshshhhhs....sshhhsss........phhuhshlshhhhalshFshuhuPlsallsuEhFP.psRstuhulAsssNW..lhsFlluhhhPhhtssls.......hhshhlFsuhhlhhhhasaahlPETKGholEclspha	.................................................................................................................................................................h...........h.......h..h.....s.............h....h......s........h................................................................................................................................................................................................................................................h.....h..h...u..h.....h........h....l..u.....t.....h.....l.....G...u...h.........h........h.......G..........h............h.......u......D........+...........h.........G....R.............+....h................s...........h......h.h....s....h.h...h.....h.........h..........h..u..s....h..h........u..h.ss......................................sh.h.h..l...h..hh............................R...h.l...........G.....h...........u.......h.......G......s.........t...............h......s...................s......s.........s...................h......h.....h........s.........E....h...u.....................s.....t....p.......h....R......G....h......h............s...............s.......h.....................p....h......h.......h.......s.........h..............G....h.........h......h....u..........h........h......h.....s....h......h..h.......h.s.................................................W......R....h.......h....h.........h....s.....h.....l....................s......l.....l....h.....h.......h............h....h.....h......h.....l.....s........E...S.......P...t....a.....h.....h................p.........t.........p........................t........p....u.............t.........h...tt..............................................................................h.............t...........................................................................................h............h..h................................h...h......h....h.....h....h.....h..................h........h.......................h...............h....................................................h..................h.........h.................h.........h..................s....................h.........h........t............h......t........h..t............................hh...hs......h.....h......h............h........h....................h....h......h.....h....h....h...s...h...........................hh....h.....c.........p.........h..........G.......R....+..................................h....h....h.....h.....s..................................h..h...h...h...h....h......h.h...h..h.h.........................h..tt..................................................h.....h.....h.....h...h..h...h....h.......h...h....h....h....h....h........t..................s.............................s............s..........h........................h....h......h.........s.......E....h...........h...s............t.....h.....R.............s.......u...h.....u....h.....s....h......................h.................t..h.................h....h.....s.....h........h.....h.......s.....h.....h..h..............h....h.....t.......h.t.............................................h...h...h...h......h..h.....h...h..............h....h......h....h.....h....h.........h......h....h...h......-.s........t....................................................................................................................................................................................................................................................................................................................	0	3767	7345	11757
+4541	PF01253	SUI1		Translation initiation factor SUI1	Finn RD, Bateman A	anon	Prosite	Domain	\N	25.50	25.50	25.50	25.60	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.91	0.72	-4.18	161	2651	2009-01-15 18:05:59	2003-04-07 12:59:11	17	21	1783	5	1143	2005	478	80.00	33	45.58	CHANGED	ttppthl.....+lphp......p+.pts...........KtVThl...pG.ls..h.tth............-lcpluKpLKpchusG.Gol...................t...sp.IplQGDppcp.lhp....hL...cpshtscp	...............................s..tpshl.....+Iphp.............pt.pts...........KsVThl...pG.ls.......h.p-h............-LccLu.ppLKK+huCG.GoV...................+..st.IplQ.GDpRcp.lpp....hLtpc.Ghthp................	0	338	612	910
+4542	PF03846	SulA		Cell division inhibitor SulA	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	30.00	30.00	30.10	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.82	0.71	-4.41	9	642	2009-09-10 23:49:51	2003-04-07 12:59:11	9	1	637	6	70	245	12	111.40	62	68.04	CHANGED	hpShass+usptShssppsupsssttsssGLISElVYpEDQPhhTQL.LLPLLQQLGpQSRW.LWLTPQQKLSRpWVQpSGLPLsKVhQlSQlsPhpTV-uM.RALpTGNYSVVlGWLs	....................................a.pStasp+uspasssspphAc.suspsssuGLlSElVY+EDQ.........PMMsQL.LLLPLLQQLG..Q..Q..SRWQLWLTPQQKLSREWVQuSGLPLTKVMQISQLuPpHTVESMlRALRTGNYSVVIGWL.............	0	5	17	43
+4543	PF00916	Sulfate_transp		Sulfate transporter family	Bateman A	anon	Pfam-B_223 (release 3.0)	Family	Mutations in Swiss:P50443 lead to several human diseases.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.58	0.70	-5.40	34	7799	2012-10-03 01:44:59	2003-04-07 12:59:11	15	65	2994	0	2983	6879	2252	253.50	24	45.21	CHANGED	hGlhRLGhllcalScsllsGFhuGsAlhIhlpQlcslhGlp....sppsthhslhpulhp.hpp..............hph.shlhuh.hLhhLhhhphls.....h......thhhhsssssLlsllluThhshhh........ptcthslshlGclssG..lsshslsp....hshshltphh.huhshullulhEulhsucshuthpshpl.DuN+EhlAhGhsNlluuhhushsuoGuhuRSslNhp.uGs+TtlSslltulhlllsllhlsslhthlPhulLuulllhsshu.Lhchpphhp..la+ls+hDhll	...................................................................................................................................hGhh+.l...Ghlh.p.a.lstsV.lhGF..hsulul.hI...hh..sQ.......ltt..h.h.....G.ht...........................t......t...h.....h.........t...........h.h.....t....s....l.h.......h..t.................................t.......s...h...h...h....u...h....h..s...l.h..h..l...h..h...h..h.hhs....................................................h..h..h...h...h..h...P...s.s.L...l..s..l.l.h......s...s.h.hshhh........................hhp.h.......s.l...s.....h......h.........G......p......l......s......su..........l.s.......s......h.......t.......h..P..........................h...............s.................h............p.................h............l.........t......t......l.....h..s.....s....u..h.....s........l.A...h....lu..h...l.........E...o...l.h..s............u....p..s....h......s......t.....h.............p......s......t..............p........h...s....s.........N...p...Eh..l.u..........Gl...u.Nlh...u...uh...h.u.u.h.s...ss.uuhuRos..........lNhp.u.G..........u+...o....t................luulhtu...lh.l....l...l....h.l.l..h....h.s....s....l..h..t.h...l....P.....h.us.Luulllhsshs.hh.c.h..p..p.h.h.t..hh.+.h.st.-h.......................................................................	0	855	1655	2449
+4544	PF03856	SUN		Beta-glucosidase (SUN family)	Finn RD	anon	DOMO:DM02469;	Family	Members of this family include Nca3, Sun4 and Sim1. This is a family of yeast proteins, involved in a diverse set of functions (DNA replication, aging,  mitochondrial biogenesis and cell septation)[1]. BGLA from Candida wickerhamii has been characterised as a Beta-glucosidase EC:3.2.1.21.	25.00	25.00	82.40	81.70	17.00	22.30	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.11	0.70	-5.08	50	297	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	121	0	204	287	0	247.20	45	59.94	CHANGED	tDGshsCupF..Posp.Gllulsalu...GGWoul...hs...............s...sussCpcGsYCSYAC.sGhsKoQW.Po.sQsosGtSl.GGLhC+.sGpLa+oNss.tchLCt.GsG..sspspNpl.upsVAlCRTDYPGoEsMlIPThVsuG.s.psLoVsDtssYYpWpGhtTSAQ........YYVNssGVSsE-GClWGosuss..lGNWAPlshGA...Ghss.GhoaLSlh.N........Ps.spst.sFslKIhusssss.luGsCpY-..sGsasu...........sGusGCTV	.....cGshsCupF..Posp..Gsluls.alu...GGWusl...hs.................s...supsCpsGsYCSYAC.PGhtKoQW..PS..sQsosGpSl.GGLaCc.sGpLh+osss..c.LC.tGsG..usp..shNch..up.sVAhCpTDYPGsEsMlIPThVsuG.sotsLsVscpss..YahWpG..TSAQ........YYVNssGVSs-DuClWG........o.s..u.ss..lGNWAPhshGAGhss.....G.tT......alSlh.N........Ps.s.sst.sFsl+Isusssus.lsusCph-.....sGsasu...............sGusGCTV.............	0	29	95	169
+4545	PF03439	Spt5-NGN	Supt5;	Early transcription elongation factor of RNA pol II, NGN section	Bateman A	anon	Bateman A	Family	Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4 [1].  Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit [2].	20.20	20.10	20.20	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.70	0.72	-4.23	64	521	2012-10-02 20:41:53	2003-04-07 12:59:11	8	26	429	5	355	529	81	83.80	32	11.04	CHANGED	slauV+s.psGpE+slshhlhp+.....ppps.......l.pIh..Slhssss....lcGYlalEAppp.sslppslpulhplpsh..........th..lslcEh.chL	..........plWsV+C.phGcE+plshtlhpKh.th.tssp.......l.pIhSlhs.-p.....lKGYIYlEA.+p.scVcpAlcGlsslhhth..............th..VPlcEhsclL............	0	111	199	297
+4546	PF01975	SurE		Survival protein SurE	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase [1].  It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family Swiss:P38254.  Swiss:P30887 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.	20.90	20.90	21.20	21.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.54	0.71	-5.01	133	3045	2009-09-11 04:46:26	2003-04-07 12:59:11	12	9	2646	51	1005	2370	1174	189.50	39	68.06	CHANGED	M+ILlTNDDGl....pAsGlpsLhcsL.pph...t.-..VhVVAPcpppSusupulTlpcPL+l.pph.............................h......haul..s.GTPsDCVtlulptl.h.tp...............P..DL..VlSGINpGsNlGpD.lhYSGTVuAAhEushhGlPuIAl....Shssp.........................t...............a....phAsphstpl.lpplh.ppsh.s........t....sslLNlNl..Ps......hs.hppl..pGl+lT+hGp+.tatpp	.....................................+ILloNDDGl........pAsGlpsLtcsL..cph................s-....VhVVAP-.............p.s.+.SG....s.Sp.u....l.T...L...pp...P....L+.h.pht............................................................................ttta.ul..sGTPsDCVhlulssl..hpt....................PDl..VlSGINtG.sNl..GcD....llYSGT....VuA.AhEGt.h.h.G..lPA.lA..l.Shssp....................................................t.........c....a....csAup....h....s....ppl..lpplh.....pps....l....s..........s...........splLNlNl....Ps.......hs...hppl.......+Gl+lT+hGp+t...pt........................................................	0	297	627	859
+4547	PF02104	SURF1		SURF1 family	Mian N, Bateman A	anon	IPR002994	Family	\N	20.80	20.80	20.90	21.00	20.70	19.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.82	0.70	-4.50	181	1742	2009-09-11 11:18:05	2003-04-07 12:59:11	10	8	1323	0	681	1517	1849	208.90	23	76.92	CHANGED	s......lhshslhls.LGhWQlpRhp.Kpsll.splppphp...s.sPl.slsth................t.............................................................pappVpls.Gpahsppphhlt.spsp.......p...................st........sGa....hVlsPhphs.........su.........phlLVsRGal.s..........t.tst............s......................................s..lplsGhl+......sp.h.tt.hh.............ts..s.t..sphhhs.........hDlst....hu.....pthsh..........htPhhlp....................................................................................................s..sh........shhp.........hsspHhsYAlpW..F..............uLAhh	...............................h.hhhhshhht..LGhWQl.pRhp...K....pphh....splp...pp..hp....t..sPl..slsph...................ts....................................................................................................................................paR+Vpls.Gpa.s.s.pp.hhlt..spsh................p.............................sp.....sGa....hVlTPhphs.........sG................phl..LVsRGal.st...p..t.s.ts......t........s..............................................................Gp.lsl..sGhl+..........spst.....t.hh.......................ts.....sss.....tthhht.............hch..s.t....hu.................p.thGh.............lts.h.h.lphstp.............................................................................................t.ss..........lss.......shhs.....................hsspHhuYAlpWauhuh..............................................................................	0	198	411	560
+4548	PF02077	SURF4		SURF4 family	Mian N, Bateman A	anon	IPR002995	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.74	0.70	-5.03	6	375	2012-10-02 13:32:46	2003-04-07 12:59:11	10	12	249	0	240	803	568	224.50	40	84.33	CHANGED	N-hhu+sEDhAE.shh+ps+sYLPpluRLhLluTFhEDGlRhhhQWs-QhpYhspsWshsaahAslFllVsllu.LhGsshVhhRp+VshAsGlLhhlllLQslAYullhshcFLhRNhullGGLLLllAEohlcp+o..hFAGlPshs-..scsKsYh.LAGRVLLlhMFloLl+F-...hSahpll.sIlGsshhlhVsIGaKTKhuAlhLVlhLhshNlhlNuaWolPpppshRDFlKYDFFQTLSlIGGLLLllshGPGtlShDE+KKcW	.......................................................................................tphE-hh-...ph.c.hK.aLPtluRhhllsTFhEDulRhhhQWs-Qh.Ylpth..hp.........h.....shhls..p..hFlhlNllu.lsusshl...lhRp..hsphAshsLhsllhh.QsluY...u.l..l.....a....D..h...pF......hhRN.lul.hG.GLLlllu.-.....Shsct+p......hF...A..G..lPp.ht-.....pp.KtYh.LuGRlLLlh..hFh.....s.....h.lh.....p....................ho.h..h.......p.........l........l.............s.l.....lG.h...h...h.......h....l........hVsl.Ga.K....sKh...uAhhLV........lh.L.hhN.l.h.h.NsaW....s.........h..............cs.h.+D..FhKY.D.FFQ.sl...Sl.lGGLLLlVshGPGtlShDE+..KK.a.............................	0	72	116	186
+4549	PF01617	Surface_Ag_2		Surface antigen	Bateman A	anon	Pfam-B_1042 (release 4.1)	Family	This family includes a number of bacterial surface antigens expressed on the surface of pathogens.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  --amino -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.63	0.70	-5.17	10	3846	2012-10-03 17:14:37	2003-04-07 12:59:11	12	3	1018	0	167	4193	20	149.70	31	84.65	CHANGED	ssuGuFYIuscYsPuhupFssFSscEs.....ps.TpsVFGlKpDhsshshspststs....Fs..sYshpapsN.FhGFuGAIGYuMsGsRlElEsuYEpF-sK.....Np.......................................Gsshcs..............................................................DA+casALo+p..s....t.shsssphlhlcN-ulsshSlMLNuCYDlhpEGlPloPYlCAGVGuDhIS.....hhpshNPKhSYQG..KlGlSYsIoPElSlFsGG+YH+VlG.NcFc-Is.shpsssssssup....sthAtlTlsssaFGsElGsRFsF	.......................................................................................................................ss.............................................................................................................................................................................................................................h.u.......t.s...Rh-h-h.hp....h.h.......................................................................................................................................................................................................................................................................................................................................................................................................s..culss.hS...sh.lNshYD...l...h.h..-...s...h.......s..l...oPY.....l..ssGlG.........u..s..hls.........................h.hs..p.....t....t.....h..uatu..........KsGlSYp.l..o..Pclp.lasG......uhY...atshs..tp........a...t...........................................................................................................................................................................................................................................................................................................................	1	26	99	118
+4550	PF00084	Sushi	sushi; 	Sushi domain (SCR repeat)	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.70	17.00	20.70	17.00	20.60	16.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.52	0.72	-3.62	66	23751	2009-01-15 18:05:59	2003-04-07 12:59:11	15	763	241	368	12142	20429	36	57.10	26	31.65	CHANGED	Cs....P......h..s..ht.t.......spaphssplpapC.psGaph.tut......sthpC...t....supWsst......s.p..C	...........................................Cs....Ps...............pG....hp..........................ssaphG.s.p.lp..a...p..C..p.....s......G......a...pL..tGs.........................sphpC.........ts..........su..p...Woss........P.t...C....................	0	3225	3866	7035
+4551	PF04099	Sybindin		Sybindin-like family 	Wood V, Finn RD	anon	Pfam-B_3240 (release 7.3);	Family	Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses [1].	21.30	21.30	21.40	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.80	0.71	-4.48	11	676	2012-10-04 00:47:01	2003-04-07 12:59:11	7	13	308	17	471	982	9	142.70	28	83.69	CHANGED	lasLYlhN+uGsLla.p-appsh.t.............................................................................thsoNEpllluuhhaSl+uIsuplSP............h.up...........sGlchlEossF+LahhpThTGlKFlllT-sss.sth-sLl+hhY-LYoDaVlKNPFYsl-MPI+sELFcppLcphlcsh	.........................................................................................................laslalhs.+t.Gshla...pca..t.t...s...t...............................................................................................................t.h.s....ss-...thhl.huhha.........S..lpuhsppLo.P...............................................................................suh...p....h.c.T.spa...+...L.ah.a..pT...T....Gl..K....Fll.h..o......-.s.........t..............t.......................s...h.....h.....c.....s........L....h....p....h...h.h.plYs-a.....V..l..K..NPh....ap.....h......c.....h....P.....l...p.s.-.hFcpplpthlp.h..................................	0	156	257	389
+4552	PF02383	Syja_N		SacI homology domain	Mian N, Bateman A	anon	Pfam-B_1090 (release 5.2)	Family	This Pfam family represents a protein domain which shows homology to the yeast protein SacI Swiss:P32368. The SacI homology domain is most notably found at the amino terminal of the inositol  5'-phosphatase synaptojanin.	20.40	20.40	21.30	20.40	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.67	158	1561	2009-01-15 18:05:59	2003-04-07 12:59:11	13	28	323	1	1068	1526	19	302.60	26	34.15	CHANGED	saGllGllcl..ps........shaLlllTpp.ppVuplt............c.........sl..a.+lpssphls..lspsthp...................................................................................................................................................................................p....pphhphlcp...........lh....ps...ssFYFS.h..s.............aDLT.............pol.....Q.....ppttttt..........................................................th-.pcFhWNpalhpsl.hphp.........................................tsppalhslIpG.............................aspptphtls.........................................................................t..hplsLIoRRSpcRAGTRahpR.Glc-c..GpVANaVETEQIlh..................................s................................................................s....................................sphhSalQhRGSlPlaWpQ..s.....s..ht........hpPplpls.sh-ssh..tuhscHFppL.hppY....................GslhllNLl...........pp+spE..thLsptapptlphh................................p..tpp...........lp..ahtFDFHpp......s...pt..hchcs	.......................................................................................................................................................................................................hGllGhlph...t........................hallllTpp.pplu.p.lh.............c...................l...a.clpssphlslppsthp............................................................................................................................................................................................................ppp.hhphlpp...lh.......ts..ssF..YF....S..h......s...................aDlT.....................pshQ....cphttt......................................................................................................................................................tphc.pp.Fh....WNphl.hp..l..hpht.....................................................................................hppahl.sll...pG.............................ahp...t.p.h.ht.......................................................................................................................................tp.hthsLIoRRSpc...+.........AGsRa.hpRG.ls..cc..................GpV.ANhVETEQllh...............................................................................................................................................................................................p..............sphhS..a...lQ..........hR.GS..lPlaWpQ...ss...hp...............hpPp.lpl.....s......th......-s.sh......tuh.p.......pHFppl..hp.pY...............................u.h.h.llNLl..................pp+...stE....thLppt..apptlp.hh............................................t.ttp............................lpahtaDaHp.s+t.....p....................................................................................................................	1	394	614	887
+4553	PF02078	Synapsin	Synapsin; Synapsin_N; 	Synapsin, N-terminal domain	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR001359	Domain	\N	20.40	20.40	20.70	30.30	20.10	18.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.39	0.72	-3.91	4	232	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	91	20	115	258	0	96.20	58	19.27	CHANGED	sstR.s+lLLVID-PHTDWuKYF+GKKlhGDhDI+VEQAEFSELNLsAassGGhhVDMQVlRNGTKVVRSFKPDFVLlRQHAauMA.sEDaRsLlIGhQYuGlPS	...................s....p.+hLLVlD.-.pTDWuKhF+GKKlp.G-aDI+VEQAEFSElNLsAausG.uhsVDM...........pVhR.....NG....o...KVV....RS.F+PDFVLlRQHAauM.u.scDaRsLlIGLQYuGlPS....................	1	22	30	66
+4554	PF02750	Synapsin_C		Synapsin, ATP binding domain	Mian N, Bateman A, Griffiths-Jones SR	anon	IPR001359	Domain	Ca dependent ATP binding in this ATP grasp fold.  Function unknown.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.35	0.71	-5.22	4	298	2012-10-10 13:17:03	2003-04-07 12:59:11	9	8	99	20	154	323	10	166.60	58	35.89	CHANGED	NSLaSlYNFCDKPWVFAQLlpIaKpLGsEcFPLIEQTaYPNHKEMLosPsFPVVVKlGHAHSGMGKVKV-NpHDFQDIASVVAlTKTYATsEPFIDuKYDIRVQKIGsNYKAYMRTSISGNWKsNTGSAMLEQIAMo-RYKLWVDoCSEhFGGLDICAVcAlHGKDGRDYIIEVhDSSMPLIGEHQ-ED+QLIsELVlsKMsQ	............................................NSL.SlYNFpsKPWVFuphlp.l.+pLG...............-pF.PLl-QTa...a...P...Na+........p..M.....l..o.h.sp....F..PVVVKhGHAHuGhGK..........l.KV-Nph.DF...QDI.uSVV.A.....hs.....p..T.......Ys..TsE..PFI.D..u.K.Y.....DlRlQKIGsN.Y..K.A.YM................RTSIS.G.NWKsN...T...G.S.AMLE.Q.lA.Mo.-RY....+l...WV.Ds.C..SEh..FGGLDICAVcAlHuK..DG+..DaI.h.E.....V.....h.....ssoMPLIG-pt.tED+pLIs-LV...ls+Ms.........................................	0	29	39	95
+4555	PF00957	Synaptobrevin	synaptobrevin; 	Synaptobrevin	Finn RD, Bateman A	anon	Pfam-B_303 (release 3.0)	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.66	0.72	-4.38	111	2176	2012-10-03 05:55:03	2003-04-07 12:59:11	16	31	380	40	1410	2035	37	80.20	29	38.98	CHANGED	ssc+lpplpsplcclpslMpcNl-.+llcRG-+l-tLsc+o-sLpssuppFcppupcL++phWW+Nh....KhhlllshllllllhlIllhhss	......................t..cpltplpsplc-Vps.......l.MpcNI.-.c...........V.L.cRGE+L-........p....L...s...-.......+o.-sLp.ss.u....p.pFc...ppApcl....p....pph..hhpp.h.......thhhhhhhhhhhhlhhh................................	0	499	779	1125
+4557	PF01284	MARVEL	Synaptophysin; 	Membrane-associating domain	Finn RD, Bateman A, Yeats C	anon	[1]	Domain	MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins [1]. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.	32.20	32.20	32.20	32.20	32.10	32.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.85	0.71	-4.37	93	2286	2012-10-03 17:26:12	2003-04-07 12:59:11	18	15	277	0	1320	2031	0	146.20	17	64.66	CHANGED	hhh..tsllRhhp...hlhu..lllhulsushh.......................................................htt..sthsashhsushshlh.shhhlls.h........hh.thshshlhhsh-hlsslhahsuhsshAsthps..................................................................tt....sttspptpAussFsahshhlahssshh	.........................................h......hhl+hhp....hlhu.llsauhh.ushh.................................................................st....s.s.....stp.a..hlhlush....salh...sl..hh...ll...h..hh.........hht.p...h...th.s...h..h..s...h.hh.ss.l..h..shh........a.h.s.ushhh.u.tt.hss................................................................................................t...h.sthtAu.........s.s..Fu..ahshhhahsshh............................................................................................................	0	214	413	813
+4558	PF01034	Syndecan		Syndecan domain	Finn RD, Bateman A	anon	Pfam-B_1182 (release 3.0)	Family	Syndecans are transmembrane heparin  sulfate  proteoglycans  which  are   implicated  in  the binding of extracellular matrix components  and growth factors.	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.17	0.72	-4.32	8	599	2009-09-13 18:19:46	2003-04-07 12:59:11	15	20	109	8	276	557	2	67.10	41	10.96	CHANGED	SpslhcRpEVL....AAVIAGGV.VGlLFAlhLVhFllYRM+KKDEGSYuL-EPK...u....Nuu.YQK.sss+EF	............s...............suhllGhV.suhhhsIhll..LahhY...+h..Rp+DEGSYpl-E...s+.......s.......................................................	0	38	59	144
+4559	PF01387	Synuclein		Synuclein	Bateman A	anon	[1]	Family	There are three types of synucleins in humans, these are called alpha, beta and gamma.  Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients. 	21.10	21.10	21.20	23.20	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.69	0.71	-4.24	4	229	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	66	9	81	186	0	111.10	60	94.74	CHANGED	MDVFhKGhShAKEGVVAAAEKTKQ...........GVsEAAEKTKEGVhYVGoKTKEGVVQuVsoVAEKTKEQAssVGGAVVouVssVApKTVEGAtNIAAAoGlVK+--hsp.....psPQEtstEsh.p...-P.sEuhEtspppG	.............MDVFMKGhShAKEGVVAAAEKTKQGVsEAAtKTKEGVhYVG...........oK..TKE.GVVpu..Vs.o.....VAEKTKEQsstVGsAVVouVssVApKTVEG...AtNIA.AATGlVKK-phsp......th.sppth.t.................................................	1	4	10	31
+4560	PF00837	T4_deiodinase		Iodothyronine deiodinase	Bateman A	anon	Pfam-B_1631 (release 2.1)	Family	Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.41	0.70	-5.36	4	345	2012-10-03 14:45:55	2003-04-07 12:59:11	12	5	107	0	155	377	21	150.70	28	86.45	CHANGED	LhhphLhsLlllPhFlusshhLhLLD.spl++Hllthtp+...................sPshshu-hs.RhhThpuL+sVW+uQhLDhaKps+.GGsAPNopVVplsGpc..................C+ILDFupGpRPLVLNFGSCTUPPFhu+hsAFpRLlpcapssADFLllYIEEAHPSDGWshssss...apI.pHQsLpDRlpAAplLLptA...PsCtVVsDTMsNsSstAYGAhFERLaVlQcG+IhYpGG+GP.uYplpElRsWLE+hp	................................................................................................................................................................................................hhhs.t.h..h....h.....p.h.p.ts...........Gt..APs...s.lh...tt....................................................................p....t..hp.hhlYltEAH.........s.........s.Dt....W..........................h..h......p.ps..p-Rh.hAp..h.....tt........................h..hhDth.ts.....at.....hh.......................................................................................................	0	50	60	90
+4561	PF03903	Phage_T4_gp36	T4_tail_gp36; 	Phage T4 tail fibre	Finn RD	anon	DOMO:DM03599;	Family	\N	27.30	27.30	27.80	27.70	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.32	0.70	-4.25	6	60	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	45	0	2	59	0	172.50	31	32.80	CHANGED	MADLKlGSTsGGSVIWHQGNFPLsPAGDDlLYKoFKIYoEYNKPQAsDNDFVSKANGGT....YtppVhFpcGlslsss...ssshsGIasGsGDGAoh-ssshclhSWhGIGFcsu.....ptsGsttlhhsspssphssRuslpus...hs.s.sP.ss.cLTRK..DY...VDusINTVTA.........NANSRVLRSGD..TMTGsLTAPNFFSQNPASQPSHVPRFDQIVIKDSVQDFGYY	.............................................MADLKhGoThGGs.lWpQGNhsL.PsusplhYKsa+.lYoE.sKPpA.s-..shVS.pusGGs...........h.t.lth...ppul..ph......stt..shhhuttsuss...........ts..sh..h.u..shuhtst...........ts..hhh...s.spss.httc.h...h.st................hthp..D....V.u.hshsst.........Nstph..ptss..shsG.L..sssphh..t................................................................................................................................................................	0	0	0	0
+4562	PF03906	Phage_T7_tail	Tail_fibre_T7; T7_tail_fibre; 	Phage T7 tail fibre protein	Finn RD	anon	DOMO:DM04804;	Family	The bacteriophage T7 tail complex consists of a conical  tail-tube surrounded by six kinked tail-fibres,  which are oligomers of the viral protein gp17.	21.20	21.20	21.20	21.80	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.83	0.71	-4.59	10	136	2009-09-10 23:06:56	2003-04-07 12:59:11	9	13	86	0	4	133	238	162.20	35	27.80	CHANGED	MAsT....ohhsYshsGosTsFsIsFE.....YLARpFVsVTLlu.....Dp+hLslNsD.YRFsssTTIohopA.hsPAsGasl.IEIRRhTusTDRLVDFsDGSlLRAhDLNlSQlQoLHlAEEARDhs.......ADoIGVssDGslDA+..GR+IVN.LAsussstDAVshtphp.shssosh	.............s...hhsaphDGsspsFslsFt.....YLs+p..VhVol.t......-pp..hsls.s-..Ypas..spsoIp..lspA......PA..s.........G......sp.lcl+RsTs..ssshLl-FscGShL.....puhDLshsphQshalApEut.Dhs..........................ss..sh.u.lssc..s.clDAc......uc+Iss.husshs.stDsssht.hp...................................................................................................................	0	1	2	4
+4563	PF02217	T_Ag_DNA_bind		Origin of replication binding protein	Bateman A	anon	Pfam-B_827 (release 5.2)	Domain	This domain of large T antigen binds to the SV40 origin of DNA replication [1]. 	25.00	25.00	34.90	34.50	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.25	0.72	-3.59	11	427	2012-10-02 18:54:06	2003-04-07 12:59:11	11	5	43	20	0	407	0	89.50	71	14.60	CHANGED	.DhPssLcuaLSpAlhoN+T.ssFLlaTTpEKsppLYspl......p+asspaphh.tpasssth.LallTss.+HRVSAVpNaCpKhCTVSFlhsKGVpKp	......KDFPsDLHsFLS..QAVFSNRTlAsFAVYTTKEKAQILYKKLM.....EKYSVTFISR..Huh..u....uHNI.....LFFLTPH.RHRVSAINNaCQKLCTFSFLICKGVNKE...	0	0	0	0
+4564	PF05010	TACC		Transforming acidic coiled-coil-containing protein (TACC)	Moxon SJ	anon	Pfam-B_4807 (release 7.6)	Family	This family contains the proteins TACC 1, 2 and 3 the genes for which are found concentrated in the centrosomes of eukaryotic and may play a conserved role in organising centrosomal microtubules. The human TACC proteins have been linked to cancer and TACC2 has been identified as a possible tumour suppressor (AZU-1) [1].  The functional homologue (Alp7) in Schizosaccharomyces pombe has been shown to be required for organisation of bipolar spindles [2].	28.80	28.80	28.90	30.30	28.50	28.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.50	0.70	-4.56	13	318	2009-12-17 14:40:01	2003-04-07 12:59:11	9	5	92	0	143	281	0	199.10	50	21.90	CHANGED	paSQKDhDAslphs+cEh..p-...........cs.-h+pKaEchppcshEMtKIlsEaEcTIsQhlE-.......................sp+p...Kplo+cplQcllpEK-Q......................shuDLNShE+SFS..................................................DLFKRaEKhKEVlEGa+K.......................................................NEEsLK....KCsp-YLsRl+KEE.................QRYQALKsHAEEKLc..................pANcEIAQVRoKApuEssALQAsLRKE.......................................QM+lpSLE+sLEQK...........................sKEh-ELTKICD-LIuKMtK	...........................................................................................h..pp.Dhsuslphh+pE..lhppE....................hEspEh..+cKYE.Ep+pEsh.EMcKIVuEYEK..TIAQ..MI...E..-..........................................................................................................cQ+p.........pphS.p...pslQpLh.hEK-Q..............................................................AhADLN.SlE+Shu..............................................................................DLF+RYE+hKpV...lEGa+K.........................................................NEEsLK......KCAp-YLuRl+.pEE..................QRYQALKhHAE...EKL-..................+ANpEIAQVRsKApsEpsALpAuLRKE.......................................Qh+V..cSLE+sLpQK...........................s+EhEELTKICDELIuKhtK.........................................................	0	36	46	81
+4565	PF02202	Tachykinin		Tachykinin family	SMART	anon	Alignment kindly provided by SMART	Family	\N	20.50	20.50	20.90	20.50	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.38	0.74	-5.50	0.74	-3.71	12	43	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	25	3	5	60	0	10.90	62	26.56	CHANGED	pPcPspFhGLM	+P+PppFaGLM	0	0	0	3
+4566	PF04972	BON	TAD;	BON domain	Yeats C, Bateman A	anon	Yeats C	Domain	This domain is found in a family of osmotic shock protection proteins (e.g. Swiss:P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes ([1]).	23.60	6.70	23.70	6.70	23.50	6.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.71	0.72	-4.22	187	8163	2009-09-11 21:46:55	2003-04-07 12:59:11	12	45	1945	6	2280	5479	2633	61.90	25	43.04	CHANGED	psplpstLttp.....tlsst.s.lpVpsp.sGtVhLpGpVs.stpptptAtplApslpG.VppVh.stlplts	...............................tplpstLhtpt......lpsp..p..lpV..psp..sG..tVhLsGpV...optptpp.Atpl.A..p.s..l.sG...Vp..p..Vt.splph..t......................	0	572	1203	1719
+4567	PF02969	TAF		TATA box binding protein associated factor (TAF)	Griffiths-Jones SR	anon	Structural domain	Domain	TAF proteins adopt a histone-like fold.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.83	0.72	-4.03	10	386	2012-10-10 12:36:46	2003-04-07 12:59:11	12	9	260	1	262	923	23	63.60	41	12.60	CHANGED	sollPpEShKVlAESlGIusLs-EsuphLA.DVpYRl+EIsQ-AlKFM+HuKRp+LTssDlDpA..LR	........................................hhst-ol+slAESlGl..s.s.Ls--ss.ph..LApDVpYRl+clh..p-AlKFM+HuKR....p....p.....LTspDlspAL+....................	0	93	143	209
+4568	PF04658	TAFII55_N		TAFII55 protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4395 (release 7.5)	Family	The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex.   TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown.  The conserved region is situated towards the N-terminus of the protein [1].  	25.00	25.00	30.10	27.40	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.18	0.71	-4.74	35	402	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	286	0	275	378	1	157.60	35	40.36	CHANGED	lEpQhILRh.P......pss-hl+pulpssshs...........slsh+....p-tR+AsVplssphau..ApLVDLPsIlEuhKThD+.KshaKoADIsQMLlshp................lps-p.shpht.........................................ph.tp.tpcpapa...HGlTPPh+slR+RRFR.+chsc...............pthpplEccVccLLct.............DpcAp......s	......................................................lEpQFILRhss...................p.sphl+phlppsphs.p.................hslphc.........tDsR+uhlpls..s..........t...hs..ApLVDLPsllEuh.K.ThD+.KshaKoADIsQ....MLlstts......................cp.shp.s..................................................tp.htpcpa.as...HGlTPPh+slRKR.RFR.Kphpp........................hph.clE....c-VccLLptDtpA..s................................................	0	89	145	216
+4569	PF05069	Phage_tail_S	tail_comp_S; 	Phage virion morphogenesis family 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	Protein S of phage P2 is thought to be involved in tail completion and stable head joining.	24.30	24.30	24.50	24.40	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.09	0.71	-4.44	46	1328	2012-10-01 19:49:39	2003-04-07 12:59:11	8	5	800	0	174	1065	22	130.20	23	91.49	CHANGED	s-hptlpphLstLhtp...sss+ptlh+pluppL+cupppRhptQpsP.DGssatshp.......htt+ps+h+ct..hhpph....phuchlpspsssssss....hGssphhAtlHQaGh....................+s.....t.....plp...............hPsRshL......GloppDcphItchlhpaLs	.............................................h...tthpphhptlhtt......tthpt..hhpplup.p.lcp.s.p.ppph.pt...pp.s.P.cG..p..satshp.....................h.+..t..p.....t.t..........p..h...pp....t.....h.............htch............ph.tp..lp..h.p.s....ss.s..ts............G...p.s....t.....h..Atl....HpaGh....................................................................pt...............hp........................................................................hstR.hL.........Ghs.tt.s.......p.l.phl.....h............................................................................................................	0	44	110	145
+4570	PF02203	TarH		Tar ligand binding domain homologue	SMART	anon	Alignment kindly provided by SMART	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.68	0.71	-4.42	88	3556	2012-10-02 01:04:29	2003-04-07 12:59:11	10	31	949	15	528	4206	102	164.70	20	30.56	CHANGED	hhp+lsIpspLhhlluhlslLhlssusLuhhuhppuspslpphhpsphtppttlspu...hhpsRhsLsR...hhhhsts...t.....sphlspA.cptlspuppsaptahshsp..ss.t-pp.hssplpppapp.hppulpshhshlpuu.shsthhphsspphpshapshtpshtp....pssps	........................hppl..+lhstLhh...lLuhh.sl..L....l..s.o..uul.shhu...lp...p...s...p...p...sh......sh.pp.....t.p.p...p.s.t..Lsp.s...h...s..........h..h....p....s.R..h...s..Ls+s...............hthhh.sp.....t........................tphlss....A....p....pp....L.p....p...u....p.p.t...a....p....p....a....t........s....hsh.......ts....tst...s...hsp...plpp...p....ap.t....h...ps...ulpt....h....h..p..h.hps....u...p....hs...s..a..hs...t.s..s..p...t..hp..shhpthhtsh.t............h..............................................................................................................................	0	59	179	344
+4571	PF00539	Tat		Transactivating regulatory protein (Tat)	Bateman A	anon	SCOP	Family	The retroviral Tat protein binds to the Tar RNA [4].  This activates  transcriptional initiation and elongation from the LTR promoter. Binding is mediated by an arginine rich region.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.89	0.72	-4.35	83	7178	2009-09-12 06:54:57	2003-04-07 12:59:11	13	3	90	16	0	5391	0	64.90	66	73.19	CHANGED	M.....-slDPplEPWp+PGSQPpTsC.NpCYCK+CCaHCQ.....lCFlpKGLGISYGRKKRt.R.R+sspsspsH	.................M......EPVDP..pLEPWpH..PGSQ.PcTAC.ssCYCKKCCaHCQ.....VCFlpKGLGISYGRKKRR..QRRRs.Pp.supsH...............................	0	0	0	0
+4572	PF01026	TatD_DNase	UPF0006;	TatD related DNase	Bateman A	anon	Pfam-B_1370 (release 3.0)	Family	This family of proteins are related to a large superfamily of metalloenzymes [1].  TatD,  a member of this family has been shown experimentally to be a DNase enzyme.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.93	0.70	-5.18	98	8430	2012-10-03 00:45:34	2003-04-07 12:59:11	16	26	4852	19	2301	6563	3019	252.30	29	93.02	CHANGED	lDsHsHLsh..th.................tp............hsphl.pc.....sppsslptl.l............................ssussh................t.php..pshplucp..ast.lasslGlHP...tpsp....................................tpchh..........ppl..pph...h.pcscllAIGEhGL.....Da..............hps.sst...........ctQpc.lFcpplplAcch.shPlllHsRc......Apc.........-hlcll........................cp.t.hsth...tslhHs............................................aoGshchspphl.ch.....GhalSluuhlsa.p..upp.....hpcll..pplPh-+lLlETDuPalsP.................................sh+........G.ppNcPshlhpssctlAc.l+s.............hsh--ltphsppNspclF.s	..........................................................................................................................................hDoHsHLs.....ta....................t.t.-................................hspll....tc...A.t.p.s.GV...p....t..h..l.....................................................s..s.u.ssh......................................................p..shp......psh.p.L.upp...............as..t..........l.....a..s.sl.G.l.....H.....P..........hp.spp............................................................................................h..pptsh............ptl..pph...........t....pps.....c....l..V..A..lGE..h...GL.Da....................hhpt.sst..............................................phQpc....sF..ppQl.....p..l.....A.....p.c......h.....s.......h....P.....ll..lHsRc........................App..............................................-.h.h.plL...........................................................................................cctt...stt..............sGlh.H..s...............................................F..oG..s....h.c.h...A.pphl..ch..................................Gha..lu..hu..G...h..lT..acp......upc.................................l+-sh.........ptl.P..l..-.....+l...LlET....D.u....PaLsP..........................................................................................hPh+......................G...cpNcPsh.....l.ht....l.s...chl....Ap..l+s......................h.s....h.-...cluph.oppNstplFt.....................................................................................................................................................................................	0	745	1397	1904
+4573	PF03430	TATR		Trans-activating transcriptional regulator 	Finn RD	anon	Pfam-B_4420 (release 6.6)	Family	This family of trans-activating transcriptional regulator (TATR), also known as intermediate early protein 1, are common to the  Nucleopolyhedroviruses.   	20.40	20.40	25.10	22.50	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.95	0.70	-5.88	5	60	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	43	0	1	63	0	525.40	31	92.51	CHANGED	pMpslppS...YsusSTPs+ssFspu.pE.sshp.p...ph.phsT-hsschshssh-suh.cos.ss...shos.u.hps.hcpscp.spAssp-ascEpstpshsEtsouhosp........t.hsEohscottsssspR+uS..............ElDSDsDsu-SScG...cKhssKPKhRp+YKKuTIQsssoLoccppasTpICTVAssspIs+YFtpD......................................FusaLpch+o-sshsuNRFSDYISETGYYMFVVKKuEc...KPFE..VlFAKaVsNlspEYTNNYYMVDNRVFVVSlN+lRFMISYKLV+EpGI-IPPSpslCsDApAER.....sshKCYFs-VKc.sFpssLINaFNLDMaYuQTTFVTLMQSlGEsKosMLLNKLYcMaQD+oLFTLPIMLSRKEPslE-s...........spsssasSsYVuQIlKYSKsVpFPpssPsptVhDcL..................slIVTQKSoLTYKYSSVANLLFscYt.p....pDNNA-uLKKVKKE.DGsttLVEQYLotNpN.DcTSHNFIVLsFK..NDERLTIAKKGhEFaWIoGEIKDIsVsDLIcKYs.RasHHVF+IsNVNRRESTThHNNLLKLLuLlLQNLlcL-DlpcaAspshsCpYc	.................................................................................................................................................................................................t.........t...........t..t......tp.h....h..stp...p..p.............sps......t.pt.tppso..................................................................c.spp..csspusp......pp.h.+s...Kh...c....phcKtthps.p.tphp.....pp.p.s.p..l.sp.lts.......tph...s..p..hh.c...........................................................htshhtph.....s...spt............pspR.Fssah.psuYYMFlVp.cscs.....c.sFc.........lhasphVpsVs.EYsspYhhlDphVhVVohs+hRFMISYpLlpchtIcIP.ppphspc...thtpp.....ss.p..CaFp-VKs.tFhshLhshFpLDhhYsQsphshLhpSlGEpKsthlhpplhpMhpD+sLFTLPl.loRKEs..pps................................sp..sSsYVppIlchScs...lpF.p....s....s.....sph..hhsp......l...................................s...hhp..pp.s.hTYKYuSVAplLasp.............ppps.sspLhKlKKE.sGshtLlEpYLststs.s.puaNFIllshK.....sDERlTIlKps.-FhWIsu.I.KD...I.ssDlIpKYp.pasHHlFslspsNR+E.sshHNshlKLLuhhhpsllsls-hhphAppphsCpa...............	1	1	1	1
+4574	PF02668	TauD		Taurine catabolism dioxygenase TauD, TfdA family	Bashton M, Bateman A, Mifsud W	anon	COG2175	Family	This family consists of taurine catabolism dioxygenases of the TauD, TfdA family.  TauD from E. coli Swiss:P37610 is a alpha-ketoglutarate-dependent taurine dioxygenase [1].  This enzyme catalyses the oxygenolytic release of sulfite from taurine [1].  TfdA from Burkholderia sp. Swiss:Q45423 is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase [2].\	      TfdA from Alcaligenes eutrophus JMP134 Swiss:P10088 is a 2,4-dichlorophenoxyacetate monooxygenase [3]. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1 [4].	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-12.03	0.70	-4.72	123	5659	2012-10-10 13:59:34	2003-04-07 12:59:11	11	59	1664	78	2098	5388	5861	240.80	19	77.33	CHANGED	ph..psls.......................hs.t.........................phtpltptl.tppGlllh+...shs.......h.......sspph.ht..................hupth..G....l....h........................................................tt........pssshhsts........................hsaHsD...s.ah........tssth....thLhsh..psss...............pG...Gp..Thhss..shtsappLs.........sphhptl..p.slphhpshttthh.....................................................ttpP.....l..lphc.............s..sucpshasss.........h......th........................................thscups.....hh.....ctlhp..hh.p.....ps..chphpapap.t.....GDlllaDNtpshHuRs.sa........................stpRplh+sh	........................................................................................................................t...................................................httl.hth..l....ph.....thl.hh+.......s.................h.........s.tt.....t..........................hspth........G...............h...............................................................................................................p.t....t..................................................h.HsDhs...a.................tssth...........thltsh..phst.....................................tG.......Gp.......T.h.a...s..s..hhtAa..ct..Ls..........sthp.phl.........p....slps.h+.s.httsht...............t......................................................................t....hhpP.....l......Vc.pH.............................P....o....G....c..p..s....l..ahst.......hspph...........sh.........................................................................s..s.-.u.pt......ll...............p.Lhp....th..p........ps.......chth.p.a.c.Wp..s....................GD...l.....hhhD.......N.t..ts.Hht...s..........................t..Rhhhth...................................................................	0	584	1221	1766
+4575	PF01361	Tautomerase		Tautomerase enzyme	Finn RD	anon	Prosite	Domain	This family includes the enzyme 4-oxalocrotonate tautomerase Swiss:Q01468 that catalyses the ketonisation of 2-hydroxymuconate to 2-oxo-3-hexenedioate.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.42	0.72	-4.36	28	2760	2012-10-01 20:38:22	2003-04-07 12:59:11	16	3	2116	139	636	2083	293	59.20	29	84.64	CHANGED	Phlplclh...cGp....osEQKcpLlcclT-shscshGt.spssltVllcEhspssauluGcshspt	.....................Phlplclh........cGc........opEQ.KppLspclT-s..lsc.....s....h.ss...s.....p.p....s..l.p....VlIpEhppssauhuGp.h...t.........................	0	159	365	504
+4576	PF02959	Tax	HTLV_tat;	HTLV Tax	Bateman A, Jeang K	anon	Pfam-B_1456 (release 6.4)	Family	Human T-cell leukaemia virus type I (HTLV-I) is the etiological agent for adult T-cell leukaemia (ATL), as well as for tropical spastic paraparesis (TSP) and HTLV-I associate myelopathy (HAM). A biological understanding of the involvement of HTLV-I and in ATL has focused significantly on the workings of the virally-encoded 40 kDa phospho-oncoprotein, Tax. Tax is a transcriptional activator. Its ability to modulate the expression and function of many cellular genes has been reasoned to be a major contributory mechanism explaining HTLV-I-mediated transformation of cells. In activating cellular gene expression, Tax impinges upon several cellular signal-transduction pathways, including those for CREB/ATF and NF-kappaB [1].	20.60	20.60	22.60	22.20	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.57	0.70	-4.89	4	661	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	18	5	0	385	0	177.20	81	65.43	CHANGED	HFPGFGQSLLFGYPVYVFGDCVQGDWCPISGGLCSARLHRHALLATCPEHQlTWDPIDGRVlu.....................................................phEPTLGp+LPoLuFP-PGLRPQNlYThWGtoVVChYLaQLSPPlTWPLlPHVIFCHPtQLGAFLTpVPhKRlEELLYKluLTTGslIlLPEDsLPTThFQPuRAP	...............................................SLLaGYPVYVFGDCVQGD.WCPISGGLCSARLHRHALLATCPEHQITWDPIDGRVIGSALQaLIPRLPSFPTQRTSKTLKVLTPPhTHTTPNIPPSFLQAMRK.Y.SPFRN...GYMEPTLGQHLPTLSFPDPGLRPQNLYTlWGuSVVChYLYQLSPPlTWPLlPHVIFCHPtQLGAFLTNVPhKRlEELLYKIuLTTGAlIILPEDCLPTTLFQPsRAP..............................................................................................	0	0	0	0
+4577	PF00683	TB	TGF-bp; 	TB domain	Bateman A	anon	Pfam-B_82 (release 2.1)	Family	This domain is also known as the 8 cysteine domain. This family includes the hybrid domains [1]. This cysteine rich repeat is found in TGF binding protein and fibrillin.	20.90	20.90	21.00	21.00	18.70	20.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.77	0.72	-4.39	34	2359	2009-01-15 18:05:59	2003-04-07 12:59:11	12	321	62	9	1128	1987	2	42.80	35	12.21	CHANGED	spCptslsst..sTKsp.CCCshGt....AWGss.CE..hCPhps.ospappl	...........tC.s.tsl.sst..sTKpp.CCC..o..h.Gp.........uW...G....ss...C..E....hCPhts..ospaptl...............	1	138	208	540
+4578	PF00566	RabGAP-TBC	TBC;	Rab-GTPase-TBC domain	SMART	anon	Alignment kindly provided by SMART	Family	Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.90	0.70	-4.86	101	7104	2009-01-15 18:05:59	2003-04-07 12:59:11	13	151	344	13	4605	6792	78	197.50	19	30.10	CHANGED	pphRtpl......W.hlhs.................................t....t..pttt.t....ppIc.hDltRThs...................ppt.ttpp.pLpplLpuauhhss...p.lG.......Ys..QGhshlsuhlL.......................hhh.s-pp....................uFhshsplh............thhhpshatpsh......t..lpthhh...hhcpllp.phhPc...lhp+.l.pc........slp..h.ashpW....hlsl.Fs.pshsh.phshR....lWD.hhh....pu......ph.lhp.hslu.ll.phh...cp.pll	.....................................................................................................................................................................................................hR..hW..h.t......................................................................................................................................................p.......pt........I...p....hDl....R.oh...............................p.........h.ttt...t.ptL.....h.......p..l.......L....h.......s....a..u.h....h...ps..............p..lG.............................................Y...s....Q........G..........h..s.............lsuslL.....................................................................................hhh....sEtp........................................uFhhhs.tlh..................hhhp..s..ha.p.s.h.............................s...........hptpht................hhp.p.l..l..p...ph.........Pp.....Lhp+..l...pp......................................h.sl..p....t..h....a.s.hpW.............hh.sl.F..........t..p.........p...........h..s.......h....p.............sh+................lWD.hhh.....pu...................................ph..lhh....lslu..ll...h.pt........................................................................................	1	1678	2429	3584
+4579	PF02970	TBCA		Tubulin binding cofactor A	Griffiths-Jones SR	anon	Structural domain	Domain	\N	23.20	23.20	23.40	23.20	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.78	0.72	-3.91	38	366	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	285	4	243	354	0	91.30	34	79.30	CHANGED	QLcIKsusl+RLlKEcthYccElppQpp+lc+h+sc....st.-cYslKpQ..cpVLpEoptMlPchpp+lppshpcLpph..lpstct.....hc-hsptp......cA	..............pLcIKTusl+RLhKEcthYc+EhcpQcp+l.......c+h+s-...........ss.-pY....slKpQ..........pclLpEochMlPcspcRlptAhtcLpph...Lpptpp......hc-hpphh................................	0	76	124	191
+4580	PF03558	TBSV_P22		TBSV core protein P21/P22	Finn RD	anon	Pfam-B_3028 (release 7.0)	Family	This protein is required for cell-to-cell movement in plants. Furthermore, the membrane-associated protein is dispensable for both replication and transcription [1].	20.60	20.60	20.60	24.80	17.30	20.50	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.14	0.71	-4.88	2	32	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	24	0	0	31	0	185.20	71	95.35	CHANGED	MDsEYEQVs+PWNELYKEATLGNKLsVNVG.EDsElPLLPSNaLsKsRluhSGGYIThRhlRI+IlPLVSRpuGVSG+LaLRDIoDTTG+KLHsTELLDLGKEIRLohpHLDFSVSsRSsVPIVFGFE-LVSPaLEGRELFSVshRWQhGLSAQsYSLP.s.WKVhYQE-sL+thhP..KKAsKTsSs.	.............MDTEYEQVNKPWNELYKEsTLGNKLhVNVGMEDtEVPLLPSNFLTKVRVuLSGGYIThRRlRIKIIPLVSRKAGVSGKLYLRDISDTT.GRKLHCTEpLDLG+EIRLTMQHLDFSVSsRSDVPIVFGFEELVSPFLEGRELFSlSlRWQFGLSpsCYSLPpuKWKVMYQEDALKsLKPSK.KKASKTDSS.V...................................	1	0	0	0
+4581	PF01840	TCL1_MTCP1		TCL1/MTCP1 family	Bateman A	anon	[1] & Pfam-B_7391 (Release 8.0)	Family	Two related oncogenes, TCL-1 Swiss:P56279 and MTCP-1 Swiss:P56278, are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [1]. This family contains two repeated motifs that form a single globular domain [1].	25.00	25.00	43.40	40.90	16.80	14.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.81	0.71	-4.61	8	104	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	31	6	50	77	0	104.10	40	95.40	CHANGED	MA.ssshpsphPhPPshLhshccsIYEDEapRsWlslsVEoocp.......s.ss+hcsplTVHLpphsslhpEshsss.lssspLPtMWpL.scspYpusDuoaWRLlcHuQhsssEpLlLcLlss	.........................t.phss.Ps+LWlhptslY.DEhpRo.Wlslshc.ssthp.................................V+lpQhpV.hG-.shpPoplssS.LPlMWQLY.Ptc+YpusDSphWcIhaHlp..l.pusp-hlLchlsc........	0	3	3	8
+4582	PF03634	TCP		TCP family transcription factor	Bateman A	anon	Pfam-B_1979 (release 7.0)	Family	This is a family of TCP plant transcription factors.  TCP proteins were named after the first characterised members (TB1, CYC and PCFs) and they are involved in multiple developmental control pathways [1][2][3].  This region contains a DNA binding basic-Helix-Loop-Helix (bHLP) structure [1][3].	19.90	17.00	20.20	20.20	19.60	16.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.60	0.71	-3.80	113	2128	2009-09-15 15:36:31	2003-04-07 12:59:11	8	3	670	0	282	2132	1	128.50	28	54.94	CHANGED	sss+KDRHSKlpTutGsRDRRlRLSltsAt+hFsLQ-hLGaDpsScTl-WLlppucsAIpclsss................................sssss.............s..........t.....t....................................................tt.ttth.t.ttspppss..hshsc...ps+....................scuRs+.....u+c.coppchphptthss	.........................................ppch.Tt.s.RsRR...hRLshthAtpFFsLQ-hLGaD+sS+Tl-WLlspSKsAIc-Lspp.........................................................p.sss..............s.s..................p...t.p..........................................................................................p...t............t..................p.....tp...............................t..........................tt...................................................................................................................................................................................................................................................	0	30	170	231
+4583	PF03645	Tctex-1		Tctex-1 family	Bateman A	anon	Pfam-B_2986 (release 7.0)	Family	Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction. 	20.50	20.50	21.00	20.70	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-4.18	104	888	2009-01-15 18:05:59	2003-04-07 12:59:11	8	19	260	9	593	840	7	100.80	26	53.99	CHANGED	ss.......clppllp.cslpptLts.t.......pY.pt.scspphsppls-plhppl.pp......h.................ppYKalVpshIhp.............................................ppspGl+suopshWDs.....ssDshsohpa..........pNcslaslssVaulhh	.....................................s.tlppllcpslpptLts.t.......tY....pt..pp...s....sphsppls......-plhppl.pch.............................................ctYKal.......V..pss.Ihp.........................................................ps.u.t.G.lcsu....opshW.....Ds.....ps..Dshsohpa..........cNpo..h..aslssVaulh...........................................	0	246	318	461
+4584	PF00838	TCTP		Translationally controlled tumour protein	Bateman A	anon	Pfam-B_1548 (release 2.1)	Domain	\N	20.80	20.80	21.20	21.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.05	0.71	-4.25	9	650	2012-10-01 21:11:27	2003-04-07 12:59:11	12	9	399	15	320	645	3	149.40	39	92.31	CHANGED	MllYKDlhosDELhSDSash.cllssllaEs-G+hVspp..us-ph.IGANPSAEGu-....EGs--sscpslDlVhsaRLpEp..uFDKKsahsYlKsYMKslps+Lpcpp.Ec..l.hFcKplpsalKplLup..FK-hpFFlGESMss...DG.VslhpYR..EsGtsPahhaaKcGLhE	..........................................MllYpDll..o..s...DEhhSDs.a......ph......c......l.h.s......s..l.......h...a.EV.cu+h..lsp...............sss.s..lG.uNs....SAEts-..............EG...s..-.....s.s..s....pslDlVhs...a..+L.........p.........Eo.........sF.s.....Kcsahs.....Y..l.K.......sYhKplps+.....L...c-...p....p..s..-p......................lp.FppsstthhK.c.l..Lup...a..Ks..hp.F..............ah..G....Eo..Mss......................DGhl...shhpY+........-su...ssPhh.haaKcGLp..........................	1	93	147	215
+4585	PF03347	TDH		Vibrio thermostable direct hemolysin	Mifsud W	anon	Pfam-B_3633 (release 6.5)	Family	\N	20.90	20.90	20.90	49.20	20.80	18.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.99	0.71	-4.70	2	84	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	15	1	2	77	0	138.50	78	90.33	CHANGED	h-LPSIPFPSPGSDElLFVVRsTThpTcpPVpshVpDaWTNRslKRKPYcDVYGQSVFTTuGSKWLouYMTVsINs+sYTMAAlSGYKcGhSoVFsKStphpL.QcaY.SVtsFVsssEpSIPShsYLDETPpYFVsVEAYESGsGphhVMCISNK.SahECcpQ.	.h-LPSl...PFPuPGSDElLFVVRsTThpTpuPVNshVsDaWTNRNlKRKPYKDVYGQSVFTTSGoKWLouYMTVNINs+sYTMAAlSGYKcGpSsVFsKS-pspL.Qc.Y.SVusFVGEs.EpSIPShhYLDETPEYFVsVEAYESGsGphhlM...........................	0	0	0	2
+4586	PF01285	TEA		TEA/ATTS domain family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	21.30	22.40	18.50	19.80	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.82	0.70	-5.32	19	717	2009-01-15 18:05:59	2003-04-07 12:59:11	13	5	216	11	331	600	0	283.20	40	76.13	CHANGED	sP........ssh.......................hpstuss..sssc.pspu.h+s.c...................pDuEsVWSs-lEpuFQpALth.PPhGRRK..hS-cGK.YGRNELIAcYIhh+TGKpRTRKQVS.................................................SHlQVL........pShLK........tD.shpphsp.psAphssups..............................sstPphpss.lcshspstYs.h.sss.sshht......hpPhs..hssP...............ssshp..shsosplphlpFshalpt.p.psDphs+..HLas+lptsp.p.ssPslch.-l+phhspFPchpuuLc-.................Lh-chP.ssuhhhl+h.hDl.sssh..t-s.........ssuhYhhs........spYEotcNhshs....sSTKV...............ho.sKQVsEKspp...caAthEpsRhhaR.phSshpEhhhsh.ppL++Lsc+YhhNSs......................ltshThhpVlos.......pso.cs.........Lsl..........s.Vacs.ssppHGs.H	..............................................................................................t...............................................................t.........................................t..p..shWs..clEpuF.puLthh....GppK..................hp.pu..+..a.G.RNELIucY............I...h......h+........T.........G....K............p......RTRK...QVS....................................SHIQVL..........................+p...h...pst.l.K...................................p......h...t...h.......t........t.................................................................................................s.....h.p........p...........as...........s.............s.......................................t.s.tth..hthp.............hhp..t............h...............h..h...................h........h................htp..............................t.hh..th..h.ph.............................t..a...........p.hpu..cph...h...ssohs...................ho.s+phscphp................................t..tt+..a....o..............................................................................................................................................................................................................................................................................................................................................................................	0	80	133	231
+4587	PF03848	TehB		Tellurite resistance protein TehB	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.07	0.71	-5.13	6	1247	2012-10-10 17:06:42	2003-04-07 12:59:11	9	8	1191	16	158	6802	2835	180.30	47	77.23	CHANGED	FaC+cEDYFpKKYNhTsTHSEVlEAVcsVpPsKsLDLGCGQGRNSLaLuLhGYDVTAhD+NssSIu.Lpcht-+EsLs.lpsulYDINuAslsEpYDFIlSTVVhMFLpscRIPpIIpNMQc+TpsGGYNLIVuAMsTsDhPCslPFSFTF+EsEL+cYYpcWEllKYNEshGpLH+TDtpGNRIKh+FuTML	................................................hhhcsEsY.F.sc.KY...t...h...s..........s..H...S........-.....V.......l......p.......A......h........p..........s......V.......p........s.......G...K.......s....L.DLGC...G.p.G...R....N.....S....L..a...L...A.........t....p........G....a...D.....V...T...A..h..D.....pN.s......h..u...l.......t....p.......l..p.........p.......I...t...p..........t............E.........s......L....-............l......p.......s......t.....l.....h.......D....l....N.....s.......h......o....h..........s.......t......p.....Y.....D....F.....I...l...S....T..V....V.....h....M....F...L.....p.......s.......c....p.......I.....P.......u...l......I...t.N.M.Q.c...p....Tp.s..G....G....Y....N....L...I.....V..s.......A........M..........D.......T...t..........D..a.........P..........C..........s...........l....s........F....P......F...s..F...K.E..........G...E....L..........t..c.Y...Y..c..s..W...E...h...l.K.Y..N..Ess.Gc...LH.+.pDtNGNRIpLRFAThL.............................................................................................................................	0	43	94	129
+4588	PF02765	POT1	Telo_bind;	Telomeric single stranded DNA binding POT1/CDC13	Mian N, Bateman A, Griffiths-Jones SR, Sammut SJ, Wood V, Mistry J	anon	pdb_1s40	Domain	This domain binds single stranded telomeric DNA and adopts an OB fold [1].  It includes the proteins POT1 and CDC13 which have been shown to regulate telomere length, replication and capping [2-4].  POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [5,6].	21.10	21.10	21.40	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.93	0.71	-4.28	48	329	2012-10-03 20:18:03	2003-04-07 12:59:11	12	6	201	64	177	352	3	138.30	21	19.57	CHANGED	assls....t.hppsthhshhullhssphs..hps.pt..scahhshpl.....hD.sh.s.t.............stlplhhappphppL........................P.lpp.GDlltlc........................................................php..............lptasschp.........usssst..................ssatlF...psshsssh.................shhtusp...aphssp-pph...lpsLhphtt	.........................h........p.sphlslhuVVhphp.s...hho.+G....sDaptslpl.....sDpoh......................sslps.plFpssh.ctL........................Ptlpp.GD.llhl+...................................................................pl+....................................lphapscht.........slssps.......................uhhhF...........tst.ss.sh....................tsst..hphstp-pphhttLh.h..t.........................................................................................	0	42	85	131
+4591	PF03070	TENA_THI-4		TENA/THI-4/PQQC family	Mifsud W	anon	Pfam-B_2039 (release 6.4) & Pfam-B_7791 (release 7.7)	Family	Members of this family are found in all the three major phyla of life: archaebacteria, eubacteria, and eukaryotes. In Bacillus subtilis, TENA is one of a number of proteins that enhance the expression of extracellular enzymes, such as alkaline protease, neutral protease and levansucrase [1].  The THI-4 protein, which is involved in thiamine biosynthesis, is also a member of this family. The C-terminal part of these proteins consistently show significant sequence similarity to TENA proteins. This similarity was first noted with the Neurospora crassa THI-4 [2]. This family includes bacterial coenzyme PQQ synthesis protein C or PQQC proteins.  Pyrroloquinoline quinone (PQQ) is the prosthetic group of several bacterial enzymes,including methanol dehydrogenase of methylotrophs and the glucose dehydrogenase of a number of bacteria [3]. PQQC has been found to be required in the synthesis of PQQ but its function is unclear.  The exact molecular function of members of this family is uncertain.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.19	0.70	-4.58	25	3227	2012-10-02 21:56:19	2003-04-07 12:59:11	11	23	2223	70	822	2427	629	201.20	20	78.91	CHANGED	cpplc.hhpphhp..HPFhttltcGsLs+pphptalhpcYhYltshs+hhu...hhhu+ssDhphhhchhpphh-thssE.....lpha.h+hs-tlGlshp-..lppppssPuscsalshhlsh.uppsshtEshsAhhsphhuhtphs..............................pphpphlp........tt..ahcalssassp.acptlpctpchlcplhphhtspt...........hpchpplhhpshpaEhsFh.stshcs	.......................................................t....p.hhpth.hp.......H.sFlppltpGsL..s..tpth..phYlhQDh.hYl.t.pasp.h.hu......hhhs.........+.....s.....s.........s....h....c...t.....h..t..h..........h...h.p...p...h..........t.s...h...htsE......................hph.a...pphh.....p.tl...G..l.s.....t...p-............hpp.t.............hs..Pss.........htYssa.hh........ph...s.........tp......s..s........h..t....p..h..h.u....uh.l.s..s.....hhYt.phu..................................pp.l...t..p.p.p.........................t..a.tpWIp.h.au...s..c......a...p...p...hl.p.........th..hp...h.......lsp.h.h.pt..h.sppt........................hpchpphahpusphEhtFa.phuhp.h...........................................................................................	0	226	474	673
+4592	PF04876	Tenui_NCP		Tenuivirus major non-capsid protein	Kerrison ND	anon	Pfam-B_6119 (release 7.6)	Family	This protein of unknown function accumulates in large amounts in tenuivirus infected cells.  It is found in all forms of the inclusion bodies that are formed after infection [1].	21.00	21.00	21.10	277.70	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.09	0.71	-4.72	4	65	2009-09-11 07:41:10	2003-04-07 12:59:11	7	1	9	0	0	61	0	173.80	81	97.70	CHANGED	spppsDVuVGPIsGLNYphLYDhLPspVSDNITL.DLK-P-+VTEssKKLILKGsl.lAYHHPLETDshFspVHKHhP-as+SFLEHLLGupspspNuhIDlGhFFslLQspLGDWITcpaLKHsN+MSKpQIKpLlspIIchAKAEuuDTEpYEcVWKKMPuYapsllp.lLHK	.V.QRTIEVSVGPIVGLDYTLLYDTLPETVSDNITLPDLKDPERVTEDTKKLILKGCVYIAYHHPLETDTLFIKVHKHIPEFCHSFLSHLLGGEDD.DNALIDIGLFFNhLQPSLGGWITKNFLRHPNRMSKDQIKhLLDQIIKMAKAESSDTEEYEKVWKKMPTYFESIIQPLLHK.	1	0	0	0
+4593	PF03300	Tenui_NS4		Tenuivirus non-structural protein NS4	Mifsud W	anon	Pfam-B_4315 (release 6.5)	Family	\N	20.60	20.60	21.00	406.10	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.66	0.70	-5.33	5	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	9	0	0	53	0	284.70	82	98.63	CHANGED	MSLu+lsSpSKSplLsDDLSE+uAK+h-cuNKKKLALSsRPL.............TKGRhTIDsAATVLGLEPFSFADVRsNoYDMFlAKQDYSIpANR+A+FsIDV-Ph.aF+KPLppaPFFRIATFAlVWIGIKGRAsGTlTFRIIDKSYlDPsDQVEVEVsYPISKNFAVLGSLPNFLuhEDtcNLQV-lsIcDuSVQNCVISRoLWFWGIERTDLPVsMEoQKTVMFEFEPLsD+slNHLSsFuNFTTNVVQ+AVs......sAFTTKuhsElDsthEFGVVKQP+......pIPI..........l+K++Shl-	MALSRLLSTSKSKVLYDDLSEESQKRVDNKNRKSLALSKRPL.............NQGRVTIDQAATMLGLEPFSFSDVKVNKYDMFIAKQDYSVKAHRKATFNILVDPY.WFHQPLTHYPFFRVATFAMVWIGIKGRASGITTLRIIDKSYVNPSDQVEVEVRYPISKNFAVLGSLANFLALEDKHNLQVSVSVDDSSVQNCVISRTLWFWGIERTDLPVSMKTsDTVMFEFEPLEDKAINHLSSFSNFTTNVVQKAVG......GAFTSKSFPELDTEKEFGVVKQPK......KIPI..........TKKSKSEV.S	0	0	0	0
+4594	PF05099	TerB		Tellurite resistance protein TerB	Bateman A	anon	COG3793	Family	This family contains the TerB tellurite resistance proteins from a a number of bacteria.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.51	0.71	-4.45	153	3006	2012-10-03 21:00:09	2003-04-07 12:59:11	8	32	1728	5	694	2123	2633	135.10	20	59.21	CHANGED	t.lpph..htphh.sss.sphtss.t............plAlsA....LhsclApADGphspsEhptlpplltpthslsstpspplhptspptppc........ssshhpasptlpcths.........cp+hpllcsLWplAhADG....phcttE-sllcclAplLslscp-hhth.....+t	..........................................................................h.hthth...................t..t..t.............h.sshs....lhsclsp.u.D.Gp.lsps..E...h..phh...p...p......lh.......p.....p.....h....s....L...p....s.....t....p..p..p...t....h...t...p....t.h.p...t...tppp........................................shsh.p..ph....h.p....p....lcp.h...............hch..t.p....t...hLchhhpl....Ah.A.D.G........plcspEcplLpplAphLGlsptph.....h...........................................	0	189	419	574
+4595	PF03741	TerC		Integral membrane protein TerC family	Bateman A	anon	COG0861	Family	This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of the group of clinical isolates for antibiotics and heavy metal ion resistance [2]. Determinant of the tellurite resistance of the strain was located on a large conjugative plasmid. Analyses showed, the genes terB, terC, terD and terE are essential for conservation of the resistance. The members of the family contain a number of conserved aspartates that could be involved in binding to metal ions.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.07	0.71	-4.84	93	6495	2012-10-03 02:02:08	2003-04-07 12:59:11	11	11	3058	0	1376	4775	2679	192.90	30	58.96	CHANGED	hslhhlEhsLSsDNhhVlullspp...lPtp.......................pc..+slhaGlhuAllhRhlhlhhushLlph.................................shlhhluGhaLlahuhchlht.h.................t.hpphhshsssh........................................hhhsllhIthsDllFulDSlhAshulo................pchhllhsuslhuIlslthhuthlsphlc+ashlphsshslLsalGsch...llps	......................................................TlhllEhlLulDNllhlullssp...LP.s.p......................p.pc.+.A.hh..h..G.l.h.h.A.l.l.h.Rhl....h..lhh.h.u.allsl.....................................................................h......sh..lhhlG.Gl.....F..Ll..apusp.lpcph.................................c.tt..c..pt.h.tt..ss.st..........................................................................................................hhhslhpIh.....lh..DllFu..l.......DS...l...lsshGhs.....................schhlh.h..s..us.ll.Alh..lhhh...s..uphl..s......p..h..lp.+..a..P..t.lth..hshshLhhIGhpLlhps..................................................................................................	1	380	808	1111
+4596	PF02342	TerD		TerD domain	Anantharaman V	anon	Anantharaman V	Domain	The TerD domain is found in TerD family proteins that include the paralogous TerD, TerA, TerE, TerF and TerZ proteins [1][2] It is found in a stress response operon with TerB and TerC.  TerD has a maximum of two calcium binding sites {2] depending on the conservation of aspartates {2]. It has various fusions to nuclease domains, RNA binding domains, ubiquitin related domains, and metal binding domains. The ter gene products lie  at the center of membrane-linked metal recognition complexes  with regulatory ramifications encompassing phosphorylation- dependent signal transduction, RNA-dependent regulation,  biosynthesis of nucleoside-like metabolites and DNA processing linked to novel pathways [2]. 	25.30	25.30	25.80	25.50	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.19	0.71	-4.96	187	3080	2012-10-09 20:46:33	2003-04-07 12:59:11	13	38	634	6	728	2301	75	182.90	29	70.99	CHANGED	hthsLsKGp...plsLscpss.......tplplsls.Wc.ttt..............................tshDLDsSshhlstt.............s+stsssphlFasphpusssul.h.......................sGDshsut....t............................................................................................sEslplsLspls...sslpcllhslolasut................Fuplpsuhl.clhst..................sspplsc......asls....shsscouhlhuclYRc.............................supW+.......hpAlGpGh......ssGlts..lsppaGhtl	.........................................................................................lsLpK.Gp...plsLsKpss......htplhluLuWcstt.tt...........................................tshDLDsSshhl..ts.....................s+st.ssschlFa..s..shp.u...s..s.....G.u..l..ht..........................................sGDshTGt.....ut.G.D............................................................................................cEplpl.cLsp.ls.....splc+llh.s.V.sIasups..............sFuplpsu.al..Rlhst..............................sspEls+......acLs....tshutcTuhl...huElYRc.................................................................supWK...FpAlGpGh.......ssGLts.lsptaGh..............................................................................................	0	203	487	654
+4597	PF03592	Terminase_2	Terminase_small; 	Terminase small subunit 	Finn RD	anon	Pfam-B_3755 (release 7.0)	Family	Packaging of double-stranded viral DNA concatemers requires interaction of the prohead with virus DNA.  This process is mediated by a phage-encoded DNA recognition and terminase protein. The terminase enzymes described so far, which are hetero-oligomers composed of a small and a large subunit, do not have a significant level of sequence homology.  The small terminase subunit is thought to form a nucleoprotein structure that helps to position the terminase large subunit at the packaging initiation site [1].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.96	0.71	-3.90	71	1427	2009-01-15 18:05:59	2003-04-07 12:59:11	11	10	1058	51	150	1030	539	147.30	23	79.63	CHANGED	LTsKQctFspEYlt.....s.hNATpAAl+A.GY.....St+o...Apshu...sc.LpcscIpphIsEt...hpchppcphhssc-lLphLsclspu-hp-.h.h..t................................................ttspthp.hpsphpD+l+Ah-h.LuK+hs........hp-c...........t.t.t.hhp..ht......s	................................LTtKQcpFsptYlp.....s....h.Ns.TpA...Al......pA..GY.....Ssco.....Ap...spuscLLc.p....s...c.......lpth.I...pch.......pp...ch....hp...c....th.......h..shppl.l..thL...tp...hths..p..pc.h...h..h...t...................................................................................................t.thh....h..p.tsc.cuhch.lh+hht....h....h.pp.............................tsst..h.................................................................................................................................................	1	40	90	117
+4598	PF03936	Terpene_synth_C		Terpene synthase family, metal binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_728 (release 3.0)	Domain	It has been suggested that this gene family be designated tps (for terpene synthase) [1].  It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.46	0.70	-5.17	87	2046	2009-09-15 09:56:15	2003-04-07 12:59:11	11	32	433	92	834	2322	3	234.00	21	48.78	CHANGED	lLclA...KLs....FNhhQthappELcpls+Wa+-hsl.scLsh.hR-RllEsYahshushaEPp..aStsRlhhsKhhhlhsllDD.....haD..sauohcE...lc....thscslcRW........s...ssh-.pLPcah+hsapslhchhp-htpchtpc.scp......hh.hhtcthpphhcuahpEucWh......pss.hhPo.h-EYhpsuhhohuhhhhhhhshhsh...sphhs.cpshchlpppsp...lhchhshhsRLh....sDltsa..........................pcEhp+GchssulpsYMcph.ssocE-Ahpclpphlppsh..+phs	..............................................................................................................................................hs...........p.....pht.t.h.......p..........p...W.........h.pp.........th.....t..p...h........h....+.....cc.....hhphhhh..h.hu.h.h.hp..Pp.....hu.tR.h.h.h.s.+.hhshhh.hh..DD............ha.D....shu..sh.c-.............hp...........hhspslp.ph..............................s........sshp..th.s.p..h...h......c..h.....h...h.....h..s..l..hs.....h...h...........p..ch.tt.phtt.p.....ttp...........................h..ht.pt..htphhp.u..hh..h.E.s..c.ah...................tps...hhPs..h...pEYh.p.t.hho.s.uh..hhhshs.hh.....hh....t..hs..cpshp..h.htp..st.............lhph...sshhh+...Lh..................sD.lhoh..........................................p.p..E.........p......c.......s.p......h..s...ss.l....h...h.h...pp......h...s.h.o.pp.Ahpthtthlppthcph...........................................................................................................................	0	148	537	713
+4599	PF02909	TetR_C	tetR_C; 	Tetracyclin repressor, C-terminal all-alpha domain	Griffiths-Jones SR	anon	Structural domain	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.52	0.71	-4.52	18	1930	2012-10-03 00:15:22	2003-04-07 12:59:11	12	6	804	87	677	1699	15	139.70	19	61.05	CHANGED	hP.pss-.sWpshLpssA+ShRpALLsaRDGA+lahGo.tsussphcshEspLphLscsGFosccAlhslpslupFslGuV........LEcQu..tpsstpspptss.hppth.s...Pl....Lppshp...shspsss-ssFEhGLpllIsGlcsth	..........................................................st..sWcstLpshAcshRpshhpH..P...t.s......s.p...l.h..h....s...p..........s..........h....u.......s......s......t......h......p....h....h-...thl.t.hL....p....s....s......Gh.s..s.t.p.s....h.t..sht...sl..t....t....alhGts.....................................h.p....p...p....s................t.....t.s..s........t........h..t...t..t..sh.....htth......................Ph..........lt.t.sht......................ht.t.........s.........c.....t..t......F.....p....hGLphllsGlt...h..........................................................................................	0	228	518	626
+4600	PF03299	TF_AP-2		Transcription factor AP-2	Mifsud W	anon	Pfam-B_1736 (release 6.5)	Family	\N	20.30	20.30	23.70	22.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.14	0.70	-4.78	6	424	2009-01-15 18:05:59	2003-04-07 12:59:11	9	5	99	0	242	359	1	190.70	64	48.09	CHANGED	ssEVFCsVPGRLSLLSSTSKY+VTVAElQRRLSPPECLNASLLGGlLRRAKSKNGG+pLR-pLcKlGLsLPAGRRKtApVThlTuLVEuEAlHLA+DFuhVCEsEFPu+slApals+pplss.p-hstR+phLhtopplsp.EltclLopDRoPlssp+spshL..-sulQpsLoHFSLhTHGFGssAhpAslpulQshlsEulphl-Khh.	.............................................sEVFCSVPGRLSLLS.ST.SKYKVTVuEVQRRLSPPECLNASLLGGVL.R..R...AK.SKNGG..Rs..LRE...+L-KIGLNL...PA....G..R...RKAA..NV...TLLTSLVE.G...............EAlHLARDFG.YlCETEFP...uKAluEa.L.sRpHt.-.s.....s.-...tsRKsMLLA..oKQlCK.EFsD.LLuQDRo..PlG...sS..RP.sPIL.......Ess.I..QssLTHFSLITHGFGsPAlCAAloAhQNYLsEuLphhDKh..h.............................................................	1	59	75	151
+4601	PF02559	CarD_CdnL_TRCF	CarD; TF_CarD; CarD_TRCF; CarD-CdnL_RID;	CarD-like/TRCF domain	Mian N, Bateman A	anon	COGs	Family	CarD is a Myxococcus xanthus protein required for the activation of light- and starvation-inducible genes [1]. This family includes the presumed N-terminal domain, CdnL.\	     CarD interacts with the zinc-binding protein CarG to form a complex that regulates multiple processes in Myxococcus xanthus [4].  This family also includes a domain to the N-terminal side of the DEAD helicase of TRCF (transcription-repair-coupling factor) proteins. TRCF displaces RNA polymerase stalled at a lesion, binds to the damage recognition protein UvrA, and increases the template strand repair rate during transcription [3]. This domain is involved in binding to the stalled RNA polymerase [3]. The family includes members otherwise referred to as CdnL, for CarD N-terminal like, whichdiffer functionally from CarD. The TRCF domain mentioned above is the RNA polymerase-interacting domain or RID [5].	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.11	0.72	-3.96	152	5749	2009-09-12 00:28:14	2003-04-07 12:59:11	11	11	4259	6	1333	4473	2560	101.50	33	11.35	CHANGED	plphGDh......VVHspHGlGpatulcphpl.......sGhp....p-..alhlpats......ss...p...lhlPlsp.lshls.Ralus..psph..hLscLusps..........W....p+ppp......Kl+psshphus-llchhu	......................LcsGDhVVH.pHGlG+ahGl...p.s.h-l.......................sGhp.........p-..YlhlpYss..........sc......pLaVPVs.p..lchlu..RYluu.............psph...sh......Lp+LGusp..............W........p+t+p..............Ksppplc-lAs-LlclY.....................................................................	0	485	917	1141
+4602	PF03529	TF_Otx		Otx1 transcription factor	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	27.10	27.10	22.30	21.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.58	0.72	-3.77	22	293	2009-09-10 18:52:32	2003-04-07 12:59:11	8	2	133	0	88	237	0	92.20	55	34.78	CHANGED	SPASIS........P...hs.DP.Lus.....uouSCM....QR..........suuYPMo.YsQu...suYu.QG...Ys.u.SoSYFuGlD.CuSYLu.PM.....HsQLsusGusLSPMuusu..Muu.Hlspus	.......................................................................................SPASlS......P........LP.-P.h.ss.......u.suSCM....QR....................ssSY.PMo.YsQu...uuYu.QG...Ys..s...SSSYFuGl.D.CuSYLu.PM........Hspht.s.........pLSPMusso.huu.Hhppp...................	0	3	11	34
+4603	PF03849	Tfb2		Transcription factor Tfb2	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	21.20	21.20	21.20	21.30	18.40	20.70	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.01	0.70	-5.82	24	407	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	301	0	280	375	6	296.10	32	69.68	CHANGED	-YLcuLPsplhs+LY.psPATCLAIaR.hLPslAKhalMpMla.-pPlshp-l-pWl+ssu.....ptppppulcpLppL+lh...........................spssst...thlpLNssF+ps.h+pALsGGtppsSFGsssspss.....pcssslshLDpYAtp+WEslLHaMVGostspt..........sSp..sVhpLLpputLhct.....sssthc......ITspGFQFLLQDsNuQlWsLLLpYLchuE........shsMDsV-lLsFLFhL......uuL-LG+uYshss.Lo-TQhphLpDL+DaGLVaQ+ps..psppFY.PTRLATsLTSsssshpssstu.pt...................................pspshppGhlIlETNaRlYAYTsSPLQIAlLuLFsclchRFsNhVsGpITRESlRpALtsGITA-QIIsaLpsHAHP	...............................................................................................................altt.hs.thhppLY.....tp.s..............hshulaR.................LP.l...A+.hlh......thl...a....h....p.p.s....ls...........tslt.........W..........s......t.p........................tpt..ppuhphLtt.L+lh...............................................t........tt......th.lss.Fp..ps.h.........p.s......LhG......u.....sp.....t......s...........................................tt..hs..ht.L-pYu.ppWEs.......lLtahVss....st.t..................u.t..shhplL..tutLhpt..........tt...t.t.........................ITp.tGF.....pFLL.-hssQlWhhhl.Ylp..h.p.................................tht.hs...s.-hLsF..lF.L....................u...pl....G............p....sYphps......h.op...s..h.........p......h.....LtcLt-hGLla...p..p..t........pt....thaa...PT...+L.A......h.........sLsss.s..s........................................................................................................................tttppGhlllETNa+lYAY...........Ts.....S.......Lp.....l.ullsLFsch.h..RhP.N..........hlsu.tlTRcSlppAlttGIT.ApQIIpaLpppAHP...............................	0	104	161	236
+4604	PF03153	TFIIA		Transcription factor IIA, alpha/beta subunit	Mifsud W	anon	Pfam-B_3542 (release 6.5)	Family	Transcription initiation factor IIA (TFIIA) is a heterotrimer, the three subunits being known as alpha, beta, and gamma, in order of molecular weight. The N and C-terminal domains of the gamma subunit are represented in Pfam:PF02268 and Pfam:PF02751, respectively. This family represents the precursor that yields both the alpha and beta subunits. The TFIIA heterotrimer is an essential general transcription initiation factor for the expression of genes transcribed by RNA polymerase II. Together with TFIID, TFIIA binds to the promoter region; this is the first step in the formation of a pre-initiation complex (PIC). Binding of the rest of the transcription machinery follows this step [1]. After initiation, the PIC does not completely dissociate from the promoter. Some components, including TFIIA, remain attached and re-initiate a subsequent round of transcription.	30.50	30.50	30.70	30.70	30.20	30.20	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.47	0.70	-4.56	31	563	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	271	8	357	547	0	253.50	22	80.52	CHANGED	+lYcsVI.-DVIsssRpsFt-p.GlDEQsLp-L+plWppKLspopsschsa-sss..sss..stp........................................t...........ss.pp.psps.sssssstshthssG...............thtstsG..hpsthPshss..ss.st.......t...............htthptshstsuuspss...........t........................................................tt.shtp.sss.ht...................................ppscustss.............t...sp.hpstt...........................hc.phhshputth..slpptspt..ttpp....................................................................................................................................hQhDGssssssp............pcp....D.-D-.......................................lppD..sssDDhs.cpDsp-..ssssVhlCpYDK...........VpRsKNKWKhpLKDGIhshsGKDYVFpKApGEuEW	...........................................................................................................................................................a..lh.tpVh.t.....p......F.p......s...t.thl.php.t.W....ptKh...t.ts..h..p...t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..s...................................p.pp.................................................................................pp-..s...D-......pc.....p...t..............tplhlC.aDK...........lpR......s+s+......WKh.LKDGlhphss+.-hhFt+s.s-h-a........................................................................................................................................	0	117	189	283
+4605	PF02268	TFIIA_gamma_N	TFIIA_gamma; 	Transcription initiation factor IIA, gamma subunit, helical domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4941 (release 5.2)	Domain	Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The N-terminal domain of the gamma subunit is a 4 helix bundle.	20.90	20.90	22.50	21.70	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.31	0.72	-4.38	21	360	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	275	4	215	313	1	47.90	50	39.93	CHANGED	saYELYR+So...lGtuLTDuLD-LIssupIsPpLAhKVLtpFDKslscsLp	.....hYpLYRpoT........lG.sLp-oLD-LIpsspIsPpLAhpVLhpFDKulspALt.............	0	74	117	179
+4606	PF02751	TFIIA_gamma_C		Transcription initiation factor IIA, gamma subunit	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_4941 (release 5.2)	Domain	Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II.  Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The C-terminal domain of the gamma subunit is a 12 stranded beta-barrel.	21.20	21.20	22.70	21.50	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.76	0.72	-4.15	26	357	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	277	4	214	301	1	50.30	52	42.76	CHANGED	psKuKloF...K.GcLcTYRFCDsVWTFIl+ssph+h.....................sppplpVDKlKIVACsu	..........pV+s+.loF...K....G+LcTYRFCDsVWTFllpDspF+....................................spphlp.l.D.K.VKIVACsu.................	0	74	115	178
+4607	PF02291	TFIID-31kDa	TFIID-31; 	Transcription initiation factor IID, 31kD subunit	Mian N, Bateman A	anon	Pfam-B_6729 (release 5.2)	Family	This family represents the N-terminus of the 31kD subunit (42kD in  drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation.	29.00	29.00	29.00	29.00	28.90	28.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.48	0.71	-4.36	5	368	2012-10-10 12:36:46	2003-04-07 12:59:11	10	8	276	1	247	382	2	121.40	39	53.69	CHANGED	cuGhoupsccsPKDAplltpIL+-hGIpEYEPRVlsQLL-FAaRYTosILcDApVYucHA+Kusl-.....lEDVRLAlssplspSFTuPPPREhLLcLAs-RNppPLPQI+PsaGlRLPPDRYCLTusNacL+	...........................t.........pphP+DAplht.lLpsh.Gl..s..p..Y.EsRVh.QhL-FA.aR..........YsoslLpDA.....tl.....Y.......u......s..H....A..t+.....s...sls.........................s-DlRLAIpsR.....hshpF..p....s...........s.........P.....P+-...h....Ll-lApp+NphPLP.................h.l..h.........s..........h.......G..R..LP...P.-+asLou.sapl.............................	0	80	126	189
+4608	PF03540	TFIID_30kDa	TFIID_30kD; 	Transcription initiation factor TFIID 23-30kDa subunit	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.00	21.00	21.20	21.00	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.30	0.72	-4.13	20	312	2009-09-14 12:53:53	2003-04-07 12:59:11	8	5	267	0	220	305	3	51.70	52	26.68	CHANGED	PhIPDuVTsaYLs+uGFps.......sDsRlsRLluLAsQKFlSDIAsDAhQau+hRs	......PhIPDAVTsaYLs+uGFps.............sDsRl.hRLluLAsQKFloDIAsDAhQas+hRt.........	0	75	121	180
+4609	PF02002	TFIIE_alpha	TFIIE;	TFIIE alpha subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits TFIIE-alpha Swiss:P29083 and TFIIE-beta Swiss:P29084 and joins the pre-initiation complex after RNA polymerase II and TFIIF [1]. This family consists of the conserved amino terminal region of eukaryotic TFIIE-alpha [2] and proteins from archaebacteria that are presumed to be TFIIE-alpha subunits also Swiss:O29501 [3].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.29	0.72	-4.53	7	544	2012-10-04 14:01:12	2003-04-07 12:59:11	12	13	435	2	355	727	205	102.50	21	29.94	CHANGED	cLlpElltphhG..tcsh.llcsLh.cucso-E-luc.LtlchsplR+lLhpLa-s+Lsca+Rt+D...-ppsWhpYYWhlphc+l.pllKt+hpphlc+LcctLchEps	............................h..lhcthhs....pt..h..hl..l-h.L.h..p..c........s.....t......l.p..-....--luchlph..pt..pplRplLtpL.p.cc+.l.l...p.h...+...p...p...p-.............................p.s.p..s....h..tp.....h......h...a...h..ls.h..c.ph....h....shl.c.h+hpphhpplctp.t................................................................	0	106	199	293
+4610	PF02186	TFIIE_beta		TFIIE beta subunit core domain	Bateman A	anon	[1]	Domain	General transcription factor TFIIE consists of two subunits, TFIIE alpha Pfam:PF02002 and TFIIE beta. TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The structure of the DNA binding core region has been solved [1] and has a winged helix fold.	22.50	22.50	22.70	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.12	0.72	-3.98	12	229	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	199	2	152	218	0	70.60	34	24.23	CHANGED	s+h.s.LthhV-YhKp+.....scPlol-El.shls.hDIsssllshLc.....p.s+lcasscs.papahslasI	.................................a.hshLthlVcahKp+.......scPLol-EIL..-php..lD..l..s.......p....p...hc..phLp............sNsKlchs..c......u.....patFKPhYsl............................	0	38	67	115
+4611	PF02270	TFIIF_beta		Transcription initiation factor IIF, beta subunit	Bateman A, Mian N	anon	Pfam-B_4519 (release 5.2)	Family	Accurate transcription in vivo requires at least six  general transcription initiation factors, in addition to RNA  polymerase II. Transcription initiation factor IIF (TFIIF) is a tetramer of two beta subunits associate with two alpha subunits which interacts directly with RNA polymerase II. The beta subunit  of TFIIF is required for recruitment of RNA polymerase II onto  the promoter.	19.40	19.40	21.20	21.30	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.70	0.70	-4.60	25	473	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	278	10	318	464	4	184.60	23	82.69	CHANGED	stDlDLssuc..p..pVWLVKlPKYLuppW........schssp....tplG+l+Ipps......ttc.pVslhLscp.ps....................plP+EYslphpssp.......spshhVFoEps..t.ppp...p..........................................................pshscKhALtG+Vs+cspshPsts-..pYt+lhpp+.thpsspP++pVphL-ch..Vspshts..suh+usssch...hh......tccKKp-uKpsRhs+p-LLDhLFpsFEcapYWslKsLccpT+.QPcuYLKEsLcpIAhhsK+GPapspapLKPEY++	........................................................................................p............p..thaLh+hP.hl....p...tW...........................tt......t...........luplhh..t.................thth...ht................................................................hPppa.h.......h.t................................s.hlhsp...............................................................................................tph.h.Ghl.p..ch.p....hhP.................p............p.....pa..p.hh.t.p.....t......p....t.l...pp............t.h..........t.h..t.t...........................................pttt.+thR..hspptl.shlathFc.c.......h...ash+tLht.h..........p.QP.................a......L+phLppls.h.hp.s....t..h.apL+s-hp.....................	3	103	173	251
+4612	PF01096	TFIIS_C	TFIIS; 	Transcription factor S-II (TFIIS)	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.20	0.72	-4.32	109	1781	2012-10-03 10:42:43	2003-04-07 12:59:11	13	25	640	94	1065	1584	290	39.10	43	20.94	CHANGED	hpCs.c...Cspccshah.phQpRSADEP.ThFapCh..pCsppW+	...........pCs..+....C.....t.p.c.c.s..hah.phQ......oRS...A..DEP.hTs....Fap.Cs..pCup+W+..........	0	343	578	851
+4613	PF04994	TfoX_C		TfoX C-terminal domain	Bateman A	anon	COG3070	Domain	TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes [1]. This family corresponds to the C-terminal presumed domain of TfoX. The domain is found associated with Pfam:PF00383 in Swiss:Q9JZR1.  It is also found as an isolated domain in some proteins suggesting this is an autonomous domain.	23.00	23.00	23.00	23.30	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.50	0.72	-4.07	48	1181	2012-10-03 02:11:09	2003-04-07 12:59:11	8	3	1046	4	158	663	24	79.70	38	45.23	CHANGED	tssR.L+-......LPNlshshEchLp+sGIcolppLcplGAhpuah+l+ps.utslslpL...LauLpGAlpGhHWsslsppc+pcLlpth	................t..pRL+D......LPNhuhplEphLtcsGIcslcpL+tlGActsal+.L+pp....sstlohcl...LatLEGAI.GlH.ss.LPts++pELhch...........................................	0	37	78	123
+4614	PF04993	TfoX_N		TfoX N-terminal domain	Bateman A	anon	COG3070	Domain	TfoX may play a key role in the development of genetic competence by regulating the expression of late competence-specific genes [1]. This family corresponds to the N-terminal presumed domain of TfoX. The domain is found as an isolated domain in some proteins suggesting this is an autonomous domain.	22.20	22.20	22.20	22.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.02	0.72	-4.14	85	1775	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	1572	2	258	995	70	89.90	27	59.84	CHANGED	lh-hl....ush.GslstRpMFGGaGlah.cuhhFAllsc.s...pLaL+u.sspspsha.pstGs....tsata..tpth.h....shsYaplstphh--tptltphs+huhpsuhp	....................c.lstL..us..lph..RsMFGuYulah.cs.......s.l.h.uhlh-....s......cLal+u.scpstphh..sppss....hsash.....th.......shpaahlstphhc.....st..Lhph.chuhpth..............................	0	60	131	199
+4615	PF00019	TGF_beta	TGF-beta; 	Transforming growth factor beta like domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	\N	20.30	20.30	20.60	20.40	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.86	0.72	-3.76	20	3712	2012-10-02 16:54:34	2003-04-07 12:59:11	15	19	848	111	1288	3220	0	95.50	38	29.32	CHANGED	sssCph+pLalsFp.DlGWspWIluPcGYhApYCpGpCsaslssphsso....spAllpsls+hh..tP.pssspPCClPT..cLsslohLahD-sps.hhl+phpsMlVcpCGCp	............................p.ptCp++sLaVsFp.-l.G..W.s.p...W.IlA...P.pu.YpAhYCpGp.Cs.a...sh.s.s.ph..sso........................sps.h...lp.s..l.h..............pth...........s.s......s..s.spsC..Cl..Po..chssloh.LYh...-..p....p....pp......hh..hc..ph.sMllptCuC.....................................................	0	194	298	677
+4616	PF00688	TGFb_propeptide		TGF-beta propeptide	Bateman A	anon	Pfam-B_110 (release 2.1)	Family	This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.43	0.70	-5.08	81	3044	2009-01-15 18:05:59	2003-04-07 12:59:11	13	32	870	4	1012	2611	12	185.70	18	54.29	CHANGED	sl...........................................s.h....tpthpppphcthcpplLphlGLp..cp...Pps............ttstssP...pah.L.-LYptht..............tppsttpss.........t...t......................usolhoFtsctphpp..........ptptpphhFslSsl...sps.cplstA-.L+lahpt..............sspspphplplaplhp.........tttt.pcLLss+h...lphs.....suWpsFDloss.lpp..Whppspp..NhG.....ltlpl.......hstct.sshssp..t.....t......................tptpPhLlsa	..............................................................................................................................................................................................................s.............h..t.ht......................................................................................................................................sp.l...ht..h............................................h.hFs.h.o....th........pt..p.......l..tAp.lh....lah.t.............................................tttthplp.lhph..t.....................ttt.....tph..lsp+h...........lphpt.................stW....sF..D.V.o..s.....s.lpp...Wh.......tpsp.......s..hG......l.lp.s.......................p...pt...pt.....t..........................................................t.pPhh.h..................................................................................................................................................	0	166	252	544
+4617	PF01702	TGT		Queuine tRNA-ribosyltransferase	Bashton M, Bateman A	anon	Pfam-B_1643 (release 4.1)	Family	This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine tRNA-ribosyltransferase modifies tRNAs for asparagine,  aspartic acid, histidine and tyrosine with queuine.  It catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine, and the addition of a cyclopentenediol  moiety to 7-aminomethyl-7-deazaguanine-34 tRNA; giving a hypermodified  base queuine in the wobble position [1,2]. The aligned region contains a zinc binding motif C-x-C-x2-C-x29-H,  and important tRNA and 7-aminomethyl-7deazaguanine binding residues [1].	23.80	23.80	23.90	23.90	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.52	0.70	-5.08	133	5152	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	4473	77	1485	3705	2879	234.20	41	60.66	CHANGED	Ecsl.plQpsl.GuD...IhhshDcss...sh.....ss...st.ctscpuhccTh+Wsc+shpth..............................ttpppsLFGIlQGGha.-...LRppusctlt.p...........s..hsGaA......lGGlusGE......sp.pphhpllc.hsss.......hLP............ps+PRYL.hGlG.pPtslltuVthGlDhFDClhPo.RhARpGphh...TppG............................................pl.............plcst.patpD..pPl..-.sCsChsC.............p.......paoRAYl+HLhpspEhlu.pLlohHNltahhplhpplRpuIpps.pht....phhpp......hhp	..........................................................................................................Ecuh.pIQps.L.GS.D..IhM.hF.DECs.......sh............ss.....sh..chsc...cSh-ho.....hR..WAcRshcta........................................phspppu..LFG...IlQ..GuhacD...LRc.pS...scsLs.p.............t..FsGYA........lGGLu.VGE............s+..ppMh.c......ll-...hsss..........hLP.........................................pc..KPR...YL..MG.VG..pP-......sLl.....-u.V.t.+.G.lD.M.FD..........CVhPT.Rs.A....RNGphh.TspG....................................................................................................................pl.........pl+NA..catpDh.pPl...D....p.Cs..C.YoC......................................p...........s.YS.RAYL+HLh+sp....E....h..........l....G....hpLsolHNLpah.pLMpplRpAItp..s..p..htpFhppFh.t......................................................................................................................................................................	0	514	934	1253
+4618	PF04858	TH1		TH1 protein	Kerrison ND	anon	Pfam-B_6070 (release 7.6)	Family	TH1 is a highly conserved but uncharacterised metazoan protein.  No homologue has been identified in Caenorhabditis elegans [1].  TH1 binds specifically to A-Raf kinase [2].	20.00	20.00	22.40	21.10	18.70	18.00	hmmbuild  -o /dev/null HMM SEED	584	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.84	0.70	-6.36	5	182	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	117	0	129	184	0	427.00	40	78.05	CHANGED	Ms-DaEs.scuWspusGcGpttu--supuE..sEsssuVlpECLc+FuT+DYIMEPuIFssLKRYFQAGGoPEsVIphLSENY+AVAQMsNLLAEWLIlTG.......VcPscVQAsVENH.............................................LKsLllK+FDP+KADuIFTEEGETPAWL-pMIcHcTWRuLlY+LAEcaP-CLMLNFTIK................LISDAGaQuEITSlS.TAAQQlEVFSRVL+TuIssILsuGsDDl++s..IEElA+MVCHGpHTYVFuQlMluVLuQEpcGGos......s+RLSQEIp+aAtcpspsATsITlA..LuuSAsaPpACpALuuMLSR................GALNPADITVLa+hYoSSD...PPPV-LIRsPsFL-LLlsuLFKsGVKI.Ns-HKuKYhaLLAYAASVh-..tKp.ps..-cslsKDELKuT..AIEcAHAIhCNss+GsSELlA-lsTLYsCI+aPVVusGVI+WV-ssVTEPuYF+LsT..-osPVHLAlLDEVAssHsuLQsQVLcLLl+LFE....S+pDEL-Ih.QLEhKKsLLDRMVcLLARGaVlPVloYlspChcR.DTDlSLIRYFVTEVLElluPPYSsDFVQLFLPlLEN-sIsGoM+uEG-sDPVoEFI..VHCKu+ahol	..................................................................................................t..t.h..pcthpth.p.DhIME.Pslhs.....lp..pYhps........GG..sP...pp..........llphLSpsYpuhAQhssLlucWLh.hs....................hp..plpthhcsp................................................LKphlhcpFDPpKADslF.otp...u...p.....sPtWL.pphI....t..................c.pWRpL...hYpLAE..t.aPc...CLhLsFsl+...................hI.SDAGaQs...EIsSlo..TAspphpVFo+VLpsslsphlp........s.....p.-.s.hpps....l.-hs+hlCpupHTYlauQshhph......Lspc....t.ps.s.s................h+Rlu...QElpp.A.ppt.psss.........hphs...........Lssu...s........t......s...ps.....ppulsuhLsp...............................ssL...ssuDlp.hLac..as.s.c......PPPlphlR..Pthl-lhh..psLFp.s.u.pl....s........ca+.cahalLAYAussh-......tpt..p........................hsp..-..-.lcs.......T..pAlEp....spsl.p..s.s..tu.t.....s...chh.uplt.pLhpsl.chPlVuhGVl+Wlc.sl..ps.p.aa..p..h.s....-psP.haLslL.-ElsshH.hhp.plLplLhplh-..............spt.s.pl-hh.th.Eh++hllD+hVpLlo..pGhVlPVl.............palpps.htp.phDhSLIRaFVoEV.....................L-hlsPPYos-Flphalshlpstplh.ssh.........t.....ht.Fh...................................................................................................	0	63	75	106
+4619	PF00314	Thaumatin	thaumatin; 	Thaumatin family	Finn RD	anon	Prosite	Domain	\N	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.25	0.70	-4.87	124	1409	2009-01-15 18:05:59	2003-04-07 12:59:11	12	29	247	50	615	1398	11	174.60	39	73.41	CHANGED	NpCsaTVWPushss...u............GGhpLssGpo..hsls...sPsu..h.uGRlWuRTsCsFsu.............u..pupCtTGDC..G..GtLpCs.G.s.GtPPsTLAEaoL..........t...t......DFYDlS.LVDGaNlPhslsPp...........s....sC.....ssuCss.....................................-lsspCPs-Lps......................................uCpSAC...........ts.....FtsspYCC.....ts.ststsCt....PotYSphFKptC..PcAYSYAhDDsoSo..FTCs.....u...ss.YplsF..C.P	......................................................................NpCsaTVWsuhhss.........s...................sG..ht..L...s.Gpo...hsls....ss..ss.....h..uGRhWu........RTsCshss......................sG..phpCtT..GDC....u..G.....hl.....pCp...u..s...ut.P...P.s.TLA..EasL...................st..ss....Da..YD...l.S.LVDG.a.NlPhthsPp...................t...sssC....psssCss..............................................................................................................................................s.ls.t.....CPsp..Lps.....................sh................uCps.sC..................................s.....a.t.p.sph.CC............................s.......tsC.......................so....a..SphF.Kp.t.C.P.pAYSYshD.D.....o....os......ao.Cs........s......ssY.lhF.C.............................................................................................................	0	129	377	515
+4620	PF01946	Thi4		Thi4 family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.60	0.70	-5.26	8	671	2012-10-10 17:06:42	2003-04-07 12:59:11	12	29	532	20	351	23606	13980	162.40	35	48.14	CHANGED	SRAhscpYacDLlcYAEoDVlIVGAGsSGLoAAYYLAKp..sLKVAIlEpplS.GGGsWhGG.LFsthVVc+PA+thLcElGItYE-pschhlVtcAA.FsSTlhSKslp.sslKlFNussVEDLIlR-......spVuGVVhNWohVphu..H.....hDP.TIcA+...............lVlsuTGHDushuuhsVKRl..h.ts..tclsG.+uh.hspAEcslV..+sTREVhPGLaVuGMtlutlcGAsRMGPhF	..........................................................t.........h....p.....h...c..h..D...VlIVGAGsuGLs.uA...h...h...L......u...ct.........sl....+....l.s.l..l...E......p........p......h.......t...........G.......G........s......h..............h..........h........G.......u...........h.....h...........................h.................h................h....p......t........................................h..........h...................t....h.........t...........h.........................................................................h.....................................................................h........h.................h..............s.h...h.........h......hp...D.lh.h.........................l......u.h.................................................................h.DP......h....................hhht.sG.H..s..............pp............................................................................t..s.h....uE..hh......s.....................................................................................................................................................................................................................................	0	103	208	290
+4621	PF01964	ThiC		ThiC family	Enright A, Ouzounis C, Morett E, Bateman A	anon	Enright A	Family	ThiC is found within the thiamine biosynthesis operon. ThiC is involved in pyrimidine biosynthesis [1]. The precise catalytic function of ThiC is still not known. ThiC participates in the formation of 4-Amino-5-hydroxymethyl-2-methylpyrimidine from AIR, an intermediate in the de novo pyrimidine biosynthesis.	25.00	25.00	27.60	27.60	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	421	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.32	0.70	-5.96	113	2842	2009-01-15 18:05:59	2003-04-07 12:59:11	13	9	2688	6	832	2312	704	430.20	62	77.26	CHANGED	TQhchA+cGllTtEMchVApcEsls..................................sEhlRpplApG+llIPsNhsH...phcPhuIGcuhpsKlNANIGsSsstssl-pEl-KhchAhcaGADTlMDLSTGG.clcplRctIlcso.slPlGTVPlYQAh....tchpstlh-ho.-.hhcslccQAcpGVDahTlHsGlshchlpthptt.pRlhGIVSRGGSlhsuWMhtppcENPLYppFDclLEIh+cYDVolSLGDGLRPGsltDAoDpAQhtELhsLGELscRAhctsVQVMlEG.PGHVPlspIctNlclpKclCcsAPFYlLGPLVTDIAPGYDHIouAIGuAlAuhtGAshLCYVTPuEHLuLPsh-DV+EGlIAtKIAAHAADlAKs..hssAp.c+DptMucARtshDWccQFpLulDP-+A+ph+ccshst......pschCoMCG.caCuh..+lspchh	..........................................TQhcYARpGIITsEMEalAlRE.N.h.s.............................................................................sEFVRcEVApGRAIIPANIN.H...PE...E.PMIIGRsFhVKlNANIGNSAloSSI-EEVEKlsWAhRWGA.DTlMDLSTG.c.pIH-..............TREWIlRNS.PVPIGTVPIYQAL....EKVsGhsE-L.TWEh.FRDTLlEQAEQGVDYFTIHAGVhL+alPhTA...cRlTGIVSRGGSIMApWCLs.HH..pENFLYpHF-EICEIhttYDVohSLGDGLRPGSItDANDcAQFuELcTLGELT+hAWca.DVQVMIEG.PGHVPMphIcpNMchphchCcEAPFYTLGPLsTDIAPGYDHITSuIGAAhIGWaGs.A.MLCYVTPKEHLG.LPN+-DV.Kp...GlIsYKIAAHAADLAKG...HPG.Ap.hRDsA..hSKARFEFRW-DQFsLuLDP-pARtaHDETLPp-s...........tKsAHFCSMCGPKFCSM+Iop-lR.......................	0	268	553	714
+4622	PF02568	ThiI		Thiamine biosynthesis protein (ThiI)	Mian N, Bateman A	anon	COGs	Family	ThiI is required for thiazole synthesis, required for thiamine biosynthesis [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.08	0.71	-4.86	8	2899	2012-10-02 18:00:56	2003-04-07 12:59:11	9	10	2786	3	551	4081	1379	188.10	39	45.56	CHANGED	GopG+VLuLLSGGIDSPVAuahhhpRGscVshlaFhstshpstcshcKlc+LAplLucaps.hph+LhVhsapclQc-lhc+s....sEshpsVlh+RsMh+lAphhAcchsscAlVTG-uLGQVASQTL-NLpVIpsso.shsIlRPLIGhDK--IlclAKcIGTa-ISIc.c.-sCohhs.K+PsT+AchppVcKhcpclph	................................Tpt+slhL.lSGGlDSs.VAuYhh..h.+....R...G...l...c..lch.l.a...F..................s...h.......s.....u....s....p.......s..h.......t...+......s....p......s........h......t...p....h.....h.....s....c.....a...u........u.................p......l.......c.....h......h....t....V......s.....F.....s.....p...l..........t.....c..I..h....ccs.................sc...s.......h....h.......l.l.......h...+.R..h.....M..h.Rh.A.s..c..l..s..c.c.h...s.s......u.l...l..TG.......E..u.....L......G.........Q..V........u......S.........Q......T......L..p......s..........h.p..............s....I...s..s.........V....o..........s...........s.............lL..R....PL..l..s.......h.......D..Kp-IIplAccI...sT.......-huhp....-hCsl.hs..cpPpscshhpchpt.Etph.........................................................................................................................................	0	185	341	458
+4623	PF00975	Thioesterase		Thioesterase domain	Finn RD, Bateman A	anon	Pfam-B_180 (release 3.0)	Family	Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics.  Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates.  There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.24	0.70	-4.13	38	5677	2012-10-03 11:45:05	2003-04-07 12:59:11	15	590	2120	48	1644	8115	689	222.20	18	14.88	CHANGED	tpLhshP.uuG.usphapsluptlss....hshtslphsuct.......hpshpplscthhstlpphtscs...PaslhGaShGuhlAaElAppLppp...GhtspsLhlhst.sPhh.sttttstthspst...............hhsthpchsth...st.hhtspphhtthlssltushpshtsht.............thshpt...........................hthhhtssc.hsshs....spt.............Wpphsstshp..hchhsGsHFhlhp...t....plhptlpptl	.......................................................................Lash......s..u..u...G..sshta...t.s..l....sp....t....Lssp.......hslh..u..l..p.....h.suht.............tt.............h....p....s.....l.....p........p...h......s....p....t......h.......h...p...t...l..........t..........p.....h...........t...........s.....p............s........P............a............h.............L.h.Ga.S.h.Guh..lA..a-...h.A.........p...p....Lppp.........Gp.p.......l...t.tL..h...l...h.....-....s.....h...s.....P..t...h.....t........t...t...t.......t...t...h.ttt.t....................................................................hhttht..p.ht.th...........s.t..h....h.t..p....t....t...h..h.......t.....h..h....h...s..h....h...t.....s...s..h.t...h..h..t.ph...t.........................................................................................h.hh.h.h...s.t....t.....s............s....h..t.............t...............................................................................W.t.t.h.h.t....t.t.ht.......hh..h...s.u.s..H.h.hht....................h................................................................................................................................................................................	0	397	893	1351
+4624	PF01289	Thiol_cytolysin		Thiol-activated cytolysin	Finn RD, Bateman A	anon	Prostie	Family	\N	19.60	19.60	20.70	20.50	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.59	0.70	-6.12	5	995	2012-10-01 20:08:01	2003-04-07 12:59:11	14	5	457	12	47	624	8	335.40	41	87.32	CHANGED	ss-pIDcaItGLNYNKNcVLsapGEuIcNhsPKEGhKcuscFIVVERKKKSINTNsuDISVlsSloSRTYPGALllANc-LlENQPDlLsVKRcPlTlSIDLPGMsNpDNpIsVpNPTpSNVssAVNsLVs+Ws-KYSpsa.NlPARlQY--pMAYScSQLpAKFGssFKslNNSLsIDFsAIScGEKQlpVluFKQIYYTVSVNtPsNPSDlFsKSVThE-LQp+GVSAEsPPlYISSVAYGRsVYVKLEToSKSs-VcAAF-AAlKGsSVpussEacsIl-NSSFKAVILGGDAp-cscVVTGDlsslRDlIK-GAsFo+KNPGlPISYTTsFLKDNplAsV+NNTEYIETTSTAYocGKINLDHSGAYVAQFpIoWDElSYDscGpEVVT+KsWDcNs+DKoAHFTTSIPLPGNARNIsIaARECTGLAWEWWRTVlD-RNLPLVKcRNVSIWGTTLYPpsSsTV	....................................................................................................................................................................................................................t.hasuul..ssp.h....ps...t.l.....h.t.ht..phphs.Lsu......s.h..h.p...ss.ushttu.lsplltph..t.t.....t.......sphpYp...s.o.ppl......th..s..ssh.....p....h.......ht..s.sltlsFt....ul.....tp.Gchp..........l.......hsaKQI...a...YsVss..s...sp.pPuch..FtpsVThcpLpthGlsspt..P..salSsVuYGRplYlKLp.Ts....S...+....S....p..c........Vp....A........A....FcAh...l...p........s....h....p....l..t..s....p....s....p..h....p..pI..h....c....pophpAVlhGGssp.ptsp....ll...s.t.p.......hs..l.c...sllp..csup.a.stc..pPuhP.IuYTosFL+DN.....hAs..h.pN.s..o-Y..l.ETps.p.tYpsucl.slDHSGAYVApa.IoW-ElsaDppGpEllp.+sW-tNspshTAtFspsI.l.tN........hRNlplhhccpTGLhWphWpTlh-ppsl.h..phplohhGTTL.sphp.................................................................	0	13	36	41
+4625	PF00108	Thiolase_N	thiolase; 	Thiolase, N-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Thiolase is reported to be structurally related to beta-ketoacyl  synthase (Pfam:PF00109), and also chalcone synthase.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.71	0.70	-5.41	22	14120	2012-10-02 12:25:54	2003-04-07 12:59:11	18	36	3652	158	4432	24361	7473	245.80	34	62.42	CHANGED	hcsVVIVuAsRTPlG.uatGuhpshsAs-Luuhslcuslc+ss..lssp..pVs-lIhGsVLpuut.GpssARpAuLtAGlPpplPAhTlN+lCuSGLpAlshuuQtItsGpu-lllAGGhEsMSpsPahh.....+sGh+hG.sh.hhD.hl..............hDuLhsshsthhMGlTAENlAcpasISRcpQDpFAlpSppKAttAhpsGpFpsEIlPVpl....p+Gc...hslspDEt.R.ssThEsLupL+PAFpKt.GTVTAGNAStlsDGAAAlllMocs	......................................................................................ppssIls.uhRTP......h..........G....p.......h........t......G.........uh.....p..s...h..p..s.s-...L...uu..................hsl...c...s...h...lp.R...........s..................s.....l.s.s.p.................tl...-....-....V....l.........h..............G....s......V...h..p......s...u..........p.......G...t....s....h...A..R.p...u.......u....l......t...A.......G...........l..P............s......l........s...u...hT......l......N..+h...CuS.Gh.pA............lth...AuptIt....s.......G.....p.s.-....ls.l..A.GGs...E....s..M...S..p..s.P..h.hh...............p....h.s.....h..p...h.....s.....p...............s.t..hh....................................s..s....h....t...s....h.....h.....s....t......h......t......M...G.......o..A..E..p.........l...A..........c..p.....a........s.............l..oR....-....p.Q............Dta.A......h.pSp.p.+.................Att..A..h..p..s.G....h.F..........p.....p.E..I..l..Pl...ph...............tp....G....t......................hhhs..p.....D........Et...R......s.........t.........oo.........h..E.t.........L.up.L.........+..P...s.....F.....p..........t......t......................G.................o..........V......................T.A...............GN.uSslsDG.AuAlllhoc.............................................................................................................................	0	1259	2619	3654
+4626	PF02803	Thiolase_C	thiolase_C; 	Thiolase, C-terminal domain	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	Thiolase is reported to be structurally related to beta-ketoacyl  synthase (Pfam:PF00109), and also chalcone synthase.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.41	0.71	-4.69	22	14316	2012-10-02 12:25:54	2003-04-07 12:59:11	13	37	3621	158	4583	11836	4437	125.10	38	31.49	CHANGED	lpPLA+IhuaussGVsP.plMGhGPs.Asp+sLc+AGls.lsDlDlhEhNEAFAuQsLust+plshD..................pKVNlpGGAIALGHPlGsSGARIlsTLlpphpccs.uphGlAohCIGGGtGsAhllE+	.................................................h.pPhAcl..h..uhussGs.........-........P....phM...s..h..G.P..s......A.s...p.......+.sLc+.....u.G.......ls....l....s.D....l....DlhE...........lNE....AFA.....u.......Q.sL.us.h...+...p...L.....u......l...s..t.............................................p..+..l..Nl.sGGAIA.lGHPlGAo.......G.......ARlls.oLlpp.......L.......c.......+............c..............s.......s.............p.............h..........G......l......s......o.....h....C..l..G..GG.GhAhllE.........................................	0	1267	2699	3788
+4627	PF00085	Thioredoxin	thiored; 	Thioredoxin	Sonnhammer ELL, Eddy SR	anon	Prosite	Domain	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.57	0.72	-4.35	50	24231	2012-10-03 14:45:55	2003-04-07 12:59:11	15	236	5259	369	9501	25842	8046	102.30	23	50.59	CHANGED	slhhlssps..Fcphltp....s...c.VlV-FaAsWCG.CKtlAPha-clApchpt.....slhlsKlDss.cs..tsluscasVcuhPTlhha+sGptss..chsGu.hstsslhphlppp	.................................................h...hstts.a..p.p.....l....t.p............p...........t..s.l..ll........c.....F..a.....A....s......W..........C...u......s....C.....+....t...l......s......P......h....h.......c...c...l...u...p...c...hpt...........................pl...p..h..s....+.........l.......-...........s...........-........p......p........................p..............l......s.................p.....p......a......s..........l......p........u......l......P.T...l..h......h....a.......c.......s......G....p.......ht...........ph........Gs....hs.tp.tl.tphlt..t......................................................................................	0	3323	5599	7830
+4628	PF00585	Thr_dehydrat_C	Thr_dehydratase_C;	C-terminal regulatory domain of Threonine dehydratase	Bateman A	anon	Bateman A	Domain	Threonine dehydratases Pfam:PF00291 all contain a carboxy terminal region.  This region may have a regulatory role. Some members contain two copies of this region. This family is homologous to the Pfam:PF01842 domain.	20.80	20.80	21.20	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.83	0.72	-4.39	16	4280	2012-10-02 00:29:19	2003-04-07 12:59:11	13	7	2590	4	1023	2991	981	90.50	33	30.33	CHANGED	EtstlttspEtlhshphPEcsGuLh+Flpslush.s.IThFcYRtpss.cpuplLsGlplsptp-..s-hhpplpchuassh-hosscshphaL	................ERs.htptpEtlaslpFPEcPGALhcFl.p.tl....u....s...c........s..IThFpY.R.......p......p........s......s....c.......t......u..........plllGl..p....l.....s.....p.....s...p-...htplhp.pL..p..p.h...G..........a.shhDlocsphh+hal...........................................	0	240	560	825
+4629	PF04163	Tht1		Tht1-like nuclear fusion protein 	Wood V, Finn RD	anon	Pfam-B_64620 (release 7.3);	Family	\N	21.00	21.00	21.10	21.00	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	544	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-13.13	0.70	-6.11	2	96	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	92	0	70	102	1	333.90	18	73.00	CHANGED	.hF..hR...hha.FhIhIpFh.oSE.hGclpshhphp.lhao-s.suhssLtpha...hhKSTChp-shthhlspC.lhNs..oID..sRlcoAIpholC-FptStl..hPppChh...GS..-Ch.cLESoSpWWhoaoupapclsplCh.s.L.hpKE..lcl.hNlT.l.cpF...l-hhl.HLh.Fp..pDp.N.hlDchsthF.N.s.E.p.ts.s.Rl..E..sLs.hpN.....hVp.c.lhpT.cQLcspIh-hNS.hhN...Essshp.plhpcLs-chs.cNsIt.StIschps-..s.hpc....LlphopD.lpp.hppN.chVNo....L.shohtLKcpLtuhp+..SEpQ.hpt.plLQhhsshLpsSh...hs.p.l..hhshhpphhp.ahthhSsl.usFAhhs.plFuThssl..chLphp++.l.sh.plpl.hlHh.shhhh.hV..ahWhT.phIhR.hualtlp.+haaL...LCull.al.a.KYRsS+hssch...lPh.c....Ya.pahtl..s.YLsshpsSLIDh	...................................................................................................h....................................................................................Chp.Aht...hh.pC..h.....pu.....p..s....l..s.............tphp..s.....AhpLulCEhpsus.h..phPppC.s..............................t.p.h.ts...ClpsLEu.ssQaWToYSushpphsshC..ptsphshEK....-phLpla...pslTclhpph..........h.pt.h...p.p.hh........p...p.p.p.pt.p.....h....h...ppltthh.p..............p..............t...p....t.....p...h....t..............h........htt..........................h..p.............t.....h.t............................................................h....................................................................................................................................................................................................................................................................................................................................................................t...........................................................................................................................................................................................................................................................................................	0	17	39	61
+4630	PF02926	THUMP		THUMP domain	Aravind L	anon	Aravind L	Domain	The THUMP domain is named after after thiouridine synthases, methylases and PSUSs [1]. The THUMP domain consists of about 110 amino acid residues.  The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains [2]. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.63	0.71	-4.31	48	6107	2009-01-15 18:05:59	2003-04-07 12:59:11	12	17	3468	22	1490	4208	349	137.50	18	30.26	CHANGED	pclpphh.t.thphphh.tthttlhlhhst.....ttptltphhthh...........hl.ph..h...........hts.tsh-clhctstplhpcphht........oFtVcscptspp................phsuh-lpctlGphlhcphs........pVcLppPDllltlElhpp.pshltlpp	...................................................................................................................................hh..........................t.h.l..t...t............shptlhc.....shhhlh................................shp+.lh..s.........................tphsh.p.....s..h..c.-.la.p.t.s.h..s...l.sh...pph.hsht........................TF.sV....p.....scptscph...............................pass.hclpc.hlssulhcpht..............................pspVsh...p.s...P.....D.....lp...lplpl.pc-..tshl.h......................................	1	431	822	1180
+4631	PF02511	Thy1		Thymidylate synthase complementing protein	Mian N, Bateman A	anon	Pfam-B_1648 (release 5.4)	Family	Thymidylate synthase complementing protein (Thy1) complements the thymidine growth requirement of the organisms in which it is found, but shows no homology to thymidylate synthase.	20.10	20.10	20.40	20.30	19.60	19.90	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.35	0.71	-4.94	163	1591	2009-09-11 08:36:29	2003-04-07 12:59:11	10	9	1413	90	459	1297	3344	199.20	24	79.78	CHANGED	Vp...........Llsh....................s........s....s-phlstAARssass...........tph.st................................................tcspthl.chlhc..puH.....hSshEass....hoFtlc.soRuls+QllRHRh.hSa.sphSpRYs.......................................................p.hpph..t.........ahl.P......phpp.s....................htp...hhpcthppuh..................................ctYpcll.pt..........................u......hup....EtARhlLP..ustTclhhohNhRsLh+.FlpLRss........ppAQh.EIRplAtthhc.hlpc...hhPhl	......................................................................................................ss.thh..AuRhsats.......................ph.t..........................ppspthl.chl.hc......htH..............tSs..hEass....hoFtlp.lS+sst+..pl..hR......HRh..sSh.......s..phSp..RYs...................................................................p.hpp......p....................ahl.P................phpp.t...............................................tht.chhpp..sh..ppuh...................................csYppll...pt................................................................................s.hup......EhA.RhlL.P..tu.hpTchhhohNhRs.Lhp...Flp..LR.s.s........pc.A...ph...EIRp.lAtthhch.ltphhP..h................................................	0	198	347	413
+4632	PF00303	Thymidylat_synt	thymidylat_synt; 	Thymidylate synthase	Finn RD	anon	Prosite	Domain	Swiss:P28176 is not included as a member of this family, Although annotated as such there is no significant sequence similarity to other members.	20.60	20.60	21.20	20.70	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.71	0.70	-5.39	141	4583	2009-01-15 18:05:59	2003-04-07 12:59:11	14	12	4044	372	1007	3278	1831	266.00	44	92.72	CHANGED	-ptYLcllccIl.......cpGpp+..........sDRTGsG...ThS.lFG..hphRac.Lpcs.......................FPLL.TTK...+Vah+ullpELLW.FlpGsTssphLp.....pp.sl+IW-t.u..............pph...............................................p.G-L.......GPlYGhQWRc...ass.............s..........................pt..lDQlpplIcpl.Ks........NPsSRRhllsA..........WNssDl.......spMALPPCHhhhQFaVs.............................c..G+...............................LSCpLYQRSsDhhLGlP.FNIASYuLLTcMlAphs.....G.....LcsG-FlHshGDsHlY..................................................pNHl-..tl.cpQLpR..pPpshPpLpl....p.....php.......sl.ca....ph-Dhp..l.sYpsas.tIc...................h.hAV	.................................................................................................h.ptYl-Lhpc.lL.......cpGs..+..........................sD.RTGo.G.....ThS.l.FG..tQhRFs...LpcG.......................FPLl.TTK......+lhh+ullpELLW..FlcG.sT.......NlphLp...........cp.slpIWD.-WAscs........................................................................................................................................G-L.........Gs.V..YGh.QWRp...Wss....................G.............................................................................................................................pt.lD.Qlpp.llcpl...K..p........s.P.s.S...R.RhI.....lSA...................W.Nss.-l...................cpMALsP.CH.s..haQF..Y..Vs........................................c..G+..........................................................LSCpLYQRSsDlaLGlP...F.N.IASY.A.L.....Ls.pMl....Ap.s..............G.......L.c........sG-FlaohGDsHlY....................................................pN.Hh..-..p..s..c...Q..Ls............R............-P..t...s.h..P...pLhl.............s....csc.........................slaDa..............ph-Dhp....l.sY..csHs.tIK.hslAl......................................................................................................	0	318	610	831
+4633	PF02223	Thymidylate_kin		Thymidylate kinase	Bateman A	anon	Pfam-B_484 (release 5.2)	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.27	0.71	-4.92	25	5133	2012-10-05 12:31:08	2003-04-07 12:59:11	12	17	4611	113	1395	4369	2991	185.50	31	82.85	CHANGED	lEGlDGuGKTTpsphltctLpspuht..hhho+EPsuo.lGchlRphLh....ptphsshs...tslLFsAsRhpclt...phItssLppuphVIsDRahhSolAYQuh.tpt..hchlhplspsshh....pPDlslhL-.lsschulpRhpt+sp......ch.tcphchhpph+ptahcLsp..spphhllcAsps.lEplpppI	....................................................................................................hEGh-GuGKoTt....h....p....h..l....h....p.t.L........p....p.............p..........G............h.............p.......hl.......h..TR.E....P......G...G....o.......l......u......E....p.l...R.pllL...........pspp.h.ssps...............EhLLah..A.u..R..tpclt.............ph.I....t..P.....A...L....p.....p....G..p......h..V.........l......s............DR.....a.........h.....s......S.o........hA........Y.............Q........G......s........u........R......s.................l.............s.............h..........p..........h.........l.....t............p.....l........p.....p........h.....s..........hts........hpP............D.L..T....laLD..lss.-...h....u....h....p....R....ht.t.psp.....................s...Rh-.p...E..s....h....c.....F....a...p...+....l....+p.t...Y...h....p........l...s....p.........t.....s..p.......c..........h.......h..h..l...D.A.....s....ps..h-pVhp..................................................................................	0	460	873	1164
+4634	PF01290	Thymosin		Thymosin beta-4 family	Finn RD, Bateman A	anon	Prosite	Family	\N	21.40	21.40	22.30	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-8.06	0.72	-4.36	25	536	2009-01-15 18:05:59	2003-04-07 12:59:11	15	14	139	15	223	588	0	39.70	49	73.45	CHANGED	uDcPchsE.....lssFDKscLKKTETpEKNsLPTKEs.I-QEKptp	....................thsE......lEpFDpsKLK+TETpEKNsLPoKEsIcpEKpt.........	0	80	94	160
+4635	PF00086	Thyroglobulin_1	thyroglobulin_1; 	Thyroglobulin type-1 repeat	Bateman A, Sonnhammer ELL	anon	Swissprot_feature_table	Domain	Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation [2]. The domain usually contains six conserved cysteines.  These form three disulphide bridges.  Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.	20.60	20.60	21.30	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.01	0.72	-4.62	20	2274	2009-01-15 18:05:59	2003-04-07 12:59:11	13	161	191	10	1102	2134	3	67.10	28	20.34	CHANGED	Cphphtph...h............tpsspshYlPsCc.ccGpYpshQCp.....ppG.CWCVDst.GpclsGo.ptpGc..spC	.......................................................................ttthtsha...l.P..p.Cc..cpG..t..ap.s............h.Q.Cc.............................psG..hCWCVDtp..G.ppl.s.G...o...p.h.t..sp..spC................................	0	270	360	665
+4636	PF04278	Tic22		Tic22-like family	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The preprotein translocation at the inner envelope membrane of  chloroplasts so far involves five proteins: Tic110, Tic55,  Tic40, Tic22 (this family) and Tic20. The molecular function of  these proteins has not yet been established [1]. 	20.10	20.10	20.50	20.60	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.49	0.70	-5.14	13	173	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	89	1	101	185	2	211.40	21	70.51	CHANGED	hp.s...............................t..t..psh.R.shsh.......hhhsshAhuu.hsstt.........t.AhuLot..........c-Vhc+LsuVPVFTlssosspPlLsospst....spSluhlalsppDAcsh.Lspl+pppP................-h.upsspVssloLuplYclspt.tt.........csptlsFpFlP-spQlcsAhplhcpsGpph.spFpGVPlFhucu..........LslppcscphhPhFFsK..........EDLpttLc+hppppsclssuhp...IcVssLEsllcshcsuc.ssth-cllFIPPtcul-ah.pphpp	...................................................................................................h..h..........................................................................................shs...........tpl.phLtslPVahlsstps....t..l.....hht..p..................ttls.h...hhh..ptp-Apth.lt.....p.lpt.....tp..............................h..ttthpVhslsL..sps.Y.ph..............................pspsl.hFpalPs.ppl.......psAh.......pl.hpp..p......spt...pt...........ht..G......V....P.lF.scs...............L..sl..p...p.t....s.....c.p........hhPhFFpK...................pslpp.lpph.ppp.p.....t..........t.p....I...tVhslpslltthp.p.....p..pt.hpphhhlPst...ht........t........................................	0	33	73	93
+4637	PF01826	TIL		Trypsin Inhibitor like cysteine rich domain	Bateman A	anon	Bateman A	Domain	This family contains trypsin inhibitors as well as a domain found in many extracellular proteins. The domain typically contains ten cysteine residues that form five disulphide bonds. The cysteine residues that form the disulphide bonds are 1-7, 2-6, 3-5, 4-10 and 8-9.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.41	0.72	-3.85	167	3970	2009-09-12 21:20:27	2003-04-07 12:59:11	12	461	156	15	2435	3452	1	56.00	32	11.06	CHANGED	C.s..ssppap.pC..ss..sC..toCsshps........Cs.........tt..ChtG..C....h....C..psG.al..hsss......pCV.hscC	..............................C.s..sspt.a...p...tC......ss...........sC..st..oCpshsss.................Cs...................pt..C..h...pG..C......h........C..............ss..G...hl.........hsss........pCVshppC.............................	0	585	787	1646
+4639	PF00121	TIM		Triosephosphate isomerase	Sonnhammer ELL	anon	Prosite	Domain	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.63	0.70	-5.31	56	7470	2012-10-03 05:58:16	2003-04-07 12:59:11	13	10	5835	333	1528	5657	2745	212.10	40	91.49	CHANGED	hhlsuNWKMst...shpcspshhpp.hstthts......slc...lhlsPshshLps.spphlp.......ssplt..lGAQNsphps.p.GAaTGElSsphLpDhGspaVllGHSERRphat...EosphlspKhttulcpGLpsl.lClGEolpp...+csspohplltpQlpshlptlstp....t....sllIAYEPVWAIGT.G+sAosppspcsathIRphltph...stphupplpIlYGGSVsssNspclhppsslDGhLlGuASLcs-sFhsIl	...................................................hlhGNWKhNt...sht..t.stth...hpt...htthhss..............ts-......lsl.ssPhhhLst...s.t..ph.hp.......................s.s.p...lt......luAQ.....Ns............hh......pt......s......GAaTGElS.stMLp-hG.spaVllGHSERRp..h..a...t...............EoD....Eh.....lscKsttAh.pp.GLps.IlClGE.......oL.-p............RE.u.....G..p.......o...-..lltpQlcusltslstp...t.....hp..................plVIA.YEPl.WAIGT.Gc.s.A.o.s.ppApphpt.hlRphltt..........stthup.p..ht.l.YG.GSVpstNst-lhs.....p..s.cl....DGhLlGGASLcsptFhtl.......................................................................	0	528	988	1298
+4640	PF02466	Tim17		Tim17/Tim22/Tim23/Pmp24 family	Mian N, Bateman A	anon	Pfam-B_2241 (release 5.4) & Pfam-B_7792 (Release 8.0)	Family	The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17 and Tim23 are thought to form the translocation channel of the inner membrane.  This family includes Tim17, Tim22 and Tim23. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 in [3].	29.70	29.70	29.70	29.70	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.81	0.71	-4.09	129	1856	2009-09-11 16:05:24	2003-04-07 12:59:11	14	27	332	0	1255	1746	12	125.60	21	61.48	CHANGED	ssstchhhss..stuathGslhGuhhsh............................................................hhthh.pssshp...phptslpsstp...s.......hutshushuhlassh........csslpt.h.R.u...+....cDhhNulhAGshoGu.lhut.....ps....Ghpshshu.uhshushuus.....hpth......tthh	.............................................................................................phh.ss.stuhhhGshhGsh.hthh...................................................................................................................th....psss..hp......php.t.s.hps..htp....tu........hu.ts...hushuslaush.............psslpp..h...R..s....................K.........cD.hNulhAGshTGu..lhuh...............ps.......Ghpsh.hh...u.u.hh.h.us.ht.uhhphh....h........................................	0	381	672	999
+4641	PF04821	TIMELESS		Timeless protein	Mifsud W	anon	Pfam-B_3454 (release 7.6)	Family	The timeless gene in Drosophila melanogaster and its homologues in a number of other insects and mammals (including human) are involved in circadian rhythm control [1]. This family includes a related proteins from a number of fungal species.	25.00	25.00	26.50	26.40	24.50	23.50	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.53	0.70	-5.14	23	381	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	261	0	242	392	4	240.50	26	24.27	CHANGED	-sssYtlu-DALtsL+DLh+aL+h.D-php..-ltRsLupuplVpsDLlslLspahp..........cs+ls.AslcLLVsLThPlEh....cs..p....ssst++ph..Lpph..uYKcAhhs...pplhpsllc.hhhsshthshu-RopcDpslIchlLhLlRNILtIssssptptcsD........-cpss+sphl.AhppQslhcLlLhlsSs..tppash.....hlLEIlhhhh+s....sspcLhtsstptotpc....sc-Lpshhc+Epu.p.....+thsp.sssoRHSRFGshhhVp	.................................thYhhts-sL...tsl+Dlh+hl+h.Dppt...sltptlutsp.llpsDLlP.lLhphtp.........................................pppl.h.ss.lclhV.LT..Ph.h...........tt......................s.t...p..pph...pl.ph..sYKc.uhhp............................tphhtslhc.hhh...hl......t..h.s.......h.......tcR......stc-.........phllchlLhLlRNlLtl...st.s.....t..t......phpsc..................................psts....pspll.shp.p.sl.cLLLhlso...s............p....p....p...ash........hllEIlhhlh+s..............ssp..pL...h...t......s.t.........p.t.........s..h......p..c.....................................................t........t.............p..............L.pshh...p.pE.tt..p.....................pthht..p.ssRHucFGs.h...........................................................................	0	90	138	205
+4642	PF05029	TIMELESS_C		Timeless protein C terminal region	Moxon SJ	anon	Pfam-B_5695 (release 7.6)	Family	The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologues of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2) [1]. mTim has been shown to be essential for  embryonic development, but does not have substantiated circadian  function[2]. Some family members contain a SANT domain in this region.	29.40	29.40	30.00	29.90	28.30	28.90	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.88	0.70	-5.58	5	232	2009-09-11 11:39:37	2003-04-07 12:59:11	8	10	182	0	164	239	1	364.30	22	35.30	CHANGED	hLHRIAaDLcMsuLLFQLSLFsLFp+lLS-Puussp.....KELcpls...+allRKFlclAssNPKlFVELLFaKssuss+ElspGYsst-stosSKRA.....sWosEEEupLc-Lalsspcl...EspDVV-WILcsLssssRsR+sll++Lh-...hGLtDoscDhhpsKS.......A.ppKupphlLWT........................uDp-l.ELpcLa.......--aRDssDlLs+l.............hcshsu+RS+AclVcK...LLsLGLlo-+RpLp.hKK+RKKpusu.h.sst.p.cs....htE-...E-p...hPcpcsccsccch..utsspsssslcs.pLtppl+pEshphsLhWLQssLhcAA-DcEED.tssQulPLlPLpEcsEEAMENcQFQ+lL+pLGlRsPt...SGpEuaWRIPhhLssspLhhhut.Lut.E..tE.c...EhpschsGEp.u-..Ep...Eccsphhct..pARpRKtGlsoscpc.ths.........cp..+usPKtpph............................................pttptppht........uo-u-pEc-D..hDE......sp.hE.psp-ts..s+p.ttsts-h...sshs.tp..c.s.hssDs-pAD-.usPch+c-KRh...............................tpls.tP.pRR+Lt...llEcDDE	..........................................hhaRlA..achchpshLFplslhplF.ch........lps......t...shs.........+Eh.phs....phll++hhph.h.tp.......p..s.....tlhsEl......LF.K..ts.sss.h.lp.Gatp......s....s.t.pc.t.................hhstt.tptp..p.plh....h.hts.....t.tt.-llphlht.Lss.s.ppR+t.....h......tt.....t.............uh......t..........h.......................................tpt......lhp..................................................................t....thp..lh...........tt.t....p.lt...............................hp......tt.......sp.t..p............hh..s........h..tt...tp.h...t...ttttt....t.............................................................................................................................t................t.......................h..h....tt............p...........s.t..............t......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ttt.t.....................................................................................................................................................................	0	52	85	130
+4643	PF00965	TIMP		Tissue inhibitor of metalloproteinase	Bateman A	anon	Pfam-B_1239 (release 3.0)	Family	Members of this family are common in extracellular regions of vertebrate species	21.40	21.40	21.50	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.73	0.71	-4.68	25	416	2012-10-01 21:39:20	2003-04-07 12:59:11	12	6	133	18	187	403	1	147.00	35	78.34	CHANGED	-ACSCs.P.sHPQpsFCsuDl...........VIRAKl....Vucp.hpsss...........thhpYclKphKhaKGhsp.....clphlaTssspul............CGlp.L-sN.tcpYLIoG..+h..DGchal..slCsalp.W-sLohoQ++GLsptYptGCs.C+Is........ChshPCh......lousscCLWTDh.hhptsh.upQucHhsC.lpcssupCuW	..................................................uCo.C......cP.Qp......taCp.uch...........Vl+uK..h...........lupp.stt.ss..............................hhhpYplK.hKhaKG.pp...........clph.....laT.s..sspul............CGl.p..Lcss..........pppYLls.G...ph....sGc.hal..slC.s..al....Wsp..Loh...sQ++....ul.....stpYp...hG...Cp....C.plh.............C.........h..sC.............hpu.scClWhsh....h.........p....h.t.............uhpuphhsC..h.p......s.CsW......................................	1	51	65	110
+4645	PF03549	Tir_receptor_M	Tir_receptor; 	Translocated intimin receptor (Tir) intimin-binding domain	Griffiths-Jones SR, Moxon SJ	anon	PRINTS	Domain	Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation [1]. This family represents the Tir intimin-binding domain (Tir IBD) which is needed to bind intimin and support the predicted topology for Tir, with both N- and C-terminal regions in the mammalian cell cytosol [2]. 	25.00	25.00	121.40	120.10	24.40	21.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.18	0.72	-3.85	3	132	2009-09-10 22:06:29	2003-04-07 12:59:11	9	2	104	8	1	79	0	66.00	83	12.33	CHANGED	PDsAASsAEoATKDQLTQEAFQNPDNQKVNIDENGNAIPSGELKDDVVAQIAEQAKAAGEpARQQA	PDAAAsAsEoAT+DQLTKEAFQNPDNQKVNIDE.GNAIPSG.LKDDVVApItEQAKAAGEpA+QQA	0	0	0	1
+4646	PF04553	Tis11B_N	Tis11B_C;	Tis11B like protein, N terminus	Kerrison ND, Mistry J	anon	DOMO:DM04398;	Family	Members of this family always contain a tandem repeat of CCCH zinc fingers Pfam:PF00642.  Tis11B, Tis11D and their homologues are thought to be regulatory proteins involved in the response to growth factors.  The function of the N terminus is unknown.	19.10	19.10	22.60	21.20	17.90	15.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.80	0.72	-3.88	6	107	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	40	0	47	82	0	114.70	52	31.66	CHANGED	MsTsVlSs.hFDh.-VhsptNKhhsas....s.......PSsus.........sLhDRKsVGTPuhsh.F.RRHSVTsss..............uKF..sQNQhlNs..............LKh-PS.....s.sTuhsNKEN+FRDRSFSEsGER...LL.....ppppPGG	............................MoTTLlSA.haDl..-hLsKs.......p.K.Ls...................s.shs..........shLD+KAVGTP.....suu.........G.......F.RRHSso..p.................sKF..ptNp.hh....uS.....................LK..E.Pu...........sAL..s+E...s+FRDRSFSEsGER...LL.....pQpQ.Gu..........................	1	4	9	19
+4647	PF01108	Tissue_fac		Tissue factor	Finn RD, Bateman A	anon	Prosite	Family	This family is found in metazoa, and is very similar to the fibronectin type III domain.  The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family Pfam:PF00041.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.52	0.72	-4.31	59	788	2012-10-03 16:25:20	2003-04-07 12:59:11	12	11	75	71	325	782	5	101.60	24	26.72	CHANGED	hhhhLlshlLhh..........ssssssslssPp......slphpShNFcplLpWcP.....sts.ssssYoVpap.......htpp..........................pWpsh........Ctphop.ppCDLTsthts....hptsYhsRVpuhsssppSsh	......................................hh.............................stlssP.p......slp.hp.S.....h.N.hc..p.l.L.pWps...........ts....s..tss.sYoVpap............hspp.................................pWpsh.........tC.tphs.p..ppCDlos.thts....hppsY..hsRV+AhhusppS........................................................................................................	0	20	41	128
+4648	PF00265	TK		Thymidine kinase	Finn RD	anon	Prosite	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.29	0.71	-4.71	13	3293	2012-10-05 12:31:08	2003-04-07 12:59:11	13	11	3022	53	635	2063	1299	177.10	38	89.01	CHANGED	GpIplIhGPMFSGKSTELlRplpRYpluph+ClllKashDsRauss.....VhoHDshphsAh....sostLp-lhsthpp..hcllGIDEuQFFs..-llpFs-phANtGKhVIlAuLcusFp+c.FssIhpLlPluEpVsKLpAlC.hCa+-.ASFotRLs......sEsplhlIGGs-pYlSVCRpCY	...........................................................................................pl.hhh.GsM.uGKo...p........pLLpt....s.....hp.a..p.............t.....s.hp..s.l....l...h.pssl.D.s...R..hutu................pVs..SR..hGhptpAh....................ss.s...h...h....p....c....l.....h..p.....p......h.........p..p.......p....h.....c...slhlDEsQF.....h.....s...pp.......l.h.p.l.s.c.l.l.s...p...h.s.l..sV..lsa......GLcsDF.+s-hFt.u.othL.L.s..h..A.D..c..ls..c..l..+..sI..C.....h..CG.....+..c.....AohshRlsps...............shh-ucQ.....l.....h...I...G.......G.....sE.........p......YhslCR+Ha............................................................	1	226	409	532
+4649	PF00693	Herpes_TK	TK_herpes; 	Thymidine kinase from herpesvirus	Bateman A	anon	Pfam-B_186 (release 2.1)	Family	\N	25.00	25.00	26.90	34.60	22.40	19.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.94	0.70	-5.24	14	508	2012-10-05 12:31:08	2003-04-07 12:59:11	13	2	87	61	0	548	0	249.80	52	70.99	CHANGED	GsaGlGKTTTucslsstssst.s.hLahPEPMsYWRshFs.oDslsuIhssQsR+ppGplust........cAshlsAphQupassPYhlhattlsshh...uuphs.s....s.P....slTLlhDRHPlAuslCaPhARYllG-hohpsLluhlAslP.EsPGsNLVVsoLs..sEHhcRLtsRuRPGEplDhshlsALRNVYuhLsNTspaLpsGss.....WRcsWspLshhssshhtphsp.sshstp...t.PsLpDTLFAhhKs.ELhsspGs.LhslHAWsLDuLss+LpsLpVFslDls	.....GPHGhGKTTTophLsuhuu.R..DcIVYVPEPMTYWpVLGA..SETIuNIYsTQHRLDpGEISAG........DAAVVMTSAQITMuhPYAlTDAVLAPHI...GGEusuS..pAPsP...uLTLlFDRHPIAALLCYPAARYLhGuMTspAlLuhluhIPss..hPGTNIVLusLP.EccHlcRLu+RpRPG.E.+.lDL..uMLsAlRpVYthLsNTl+YLQtGup......WR-DWGpLsu..sAh..phscsps....s...t.PcIt-TLFslF+sPELhsssG-.LhplaAWsLDsLAp+LpshplFhLDh.c....................................................................................................	0	0	0	0
+4650	PF03219	TLC		TLC ATP/ADP transporter	Mifsud W	anon	Pfam-B_2261 (release 6.5)	Family	\N	19.30	19.30	20.20	19.30	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.75	0.70	-6.02	27	560	2012-10-03 03:33:39	2003-04-07 12:59:11	9	8	194	0	186	483	158	424.20	32	84.80	CHANGED	tsptppthuc...........h+thhWPlcthElpKhlPhslhhFhILFNYslLRshKDolVlTuh...GAElIsFLKlWsllPuAllhhllYsKLuNhhopEplFYhllssFLsFFhlFuallYPhp-hlHPss.s.phhshl.sshphhlshhtpWoaulFYlhuELWuolVloLLFWtFANpITplpEAKRFYsLaGlhuNhuLlluGphlhahus.........hhpths.sl...csathplphlhslllluGllhlhlahhls+.V.........Lsssph...........sshppt.+KpKsKholt-ShphlhpS+YlhhIAlLVluYGlsINLVEssWKupl+plYPss.......s-YssFMGphsshTGlsollhh.hlGusllR+hGWthuAllTPlllllTGlhFFuhllFpcpls.hhush.GhsPLhlAVhlGuhQNlhSKusKYSLFDsTKEMAYIPLDpE.KsKGKAAlDVlGu+lGKSGGulIQphlhllh...uohss.sPaluslhllllllWlhuVppLs+pa	...............................................................................................................................................................hpthhhslp...hEhpKhlPhshhhFhIhhN.shlRshKDslllst....uAEhlsFlKhahshP.u.hlhhll..YsKLs.s.h...hshct.lFahlhs.FlhFFslFuhll.a.P..t.....ch....hH.......ps...h..............p..............h..........h..............st...ht.h....hl...h...l...ht.pWoas..laYlhuELWsslhhslLF...WtFANpITpscEAKRFYslhulhuNhullhuG.hlhhhup........................hh..h...ts...ss.th.l....h..h.slllhsuh.lhhhha.....h.hl.s+..l............................lsp.h..................thhpt.cpp+.Kh.uhh...-Sh.phlh....pS+YlhhlAlll.lsYGls.......I.N....L.........VEs....sWK....upl....+....p..ha.P.ss................ppY...ssa..h.Gpa....hh..s.Gl...ss...l................hhh...hl.....u..s...sl...l.RphGWhhuAhlT...Pl.hh.h.....l..T..G......h.h.FF.....u.hlh..F....t......p...h.......s.....h....h.....ss.h.................h..h.......sP.Lh......l..A.lh....l...G....ul..Q..NllS.....KusKYoLFDsoKEMAYIPLDp-hKs.KGKAAlDVlus+lGK..SuGullQphhhh.lh....uohssh..sshlhhh.hhllhhhWlhusttLsppa......................................................................................................	1	91	121	149
+4651	PF05017	TMP		TMP repeat	Bateman A	anon	Pfam-B_1012 (release 7.6)	Repeat	This short repeat consists of the motif WXXh where X can be any residue and h is a hydrophobic residue. The repeat is name TMP after its occurrence in the  tape measure protein (TMP). Tape measure protein is a component of phage tail and probably forms a beta-helix. Truncated forms of TMP lead to shortened tail fibres [1]. This repeat is also found in non-phage proteins where it may play a structural role.	15.00	2.90	15.00	2.90	14.90	2.80	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.78	-6.01	0.78	-6.19	0.78	-2.30	95	345	2009-09-16 13:22:24	2003-04-07 12:59:11	9	15	44	0	65	324	23	10.90	35	10.45	CHANGED	WssIpshhssh	WsuI+shhos.....	0	54	56	56
+4652	PF02581	TMP-TENI		Thiamine monophosphate synthase/TENI	Mian N, Bateman A, Griffiths-Jones SR	anon	COGs	Family	Thiamine monophosphate synthase (TMP) (EC:2.5.1.3) catalyses the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine  phosphate [1]. This Pfam family also includes the regulatory protein TENI (Swiss:P25053).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.00	0.71	-5.16	89	5722	2012-10-03 05:58:16	2003-04-07 12:59:11	12	31	3919	62	1431	4669	2676	177.90	29	71.70	CHANGED	lYhlTsst.t........tp...hhchlcpAlpu..........G.lshlQlRpK.....p....hss...pphhphApplttlsc..ph..ss.hllND..clclAht.....lsA.......DGVHlGQ...cDh.ssspsRplhusshllGlSspshp-...stpAt...ptus..DYluhGslasTsTKtss..pshGlptl.pphtpthp..........l....PllAIGGIshpslsplh........psGssulAVloAl	.............................................................................................................................ahlss................tt...hhphl..cp.s.l..pu.....................G...ls..hlQ..lRpK..................................s......h.s.s......p..c.hh.p......h......stp......l.ttl.s.c........pa..........ss...ll..lN......D.....c.h....cl..Aht..........h.s.A...........c..G....V..Hl..GQ................c.D...h.........s.........s......s.......p......h....+......p....l....h...........s.......s................s.....h.......l.......l.G.lS..s.+..shp-.....htpAt..................t.t.ss......DY.....lu..l......G....s.l.a.s........T.s..o.......Kp...s........s...ss..hG......l....p..t...l...p.ph.t.p.t.hs..............................l..PlVAIGG..I..s..h..p..s.h..s.p.lh..............t.sG...s...sulAVlsul.............................................................................................	0	467	957	1229
+4653	PF00721	TMV_coat		Virus coat protein (TMV like)	Bateman A	anon	Pfam-B_746 (release 2.1)	Domain	This family contains coat proteins from tobamoviruses, hordeiviruses, Tobraviruses, Furoviruses and Potyviruses.	23.00	23.00	23.50	23.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.92	0.71	-4.29	47	557	2009-09-11 05:07:10	2003-04-07 12:59:11	16	2	125	27	6	518	0	140.10	31	54.13	CHANGED	sYs...hss...pphhhhsssaschpshhshlpshpuspapspsuRstltstlusl.h......psssshspRFPss.s......h....hlhhtssslt.llssLhsuhc..ocsRhhEhppss....ssssups.s.....ssptssD..ush.sl+ssltplhstLsp.t....sshasp.....spFE	........................Ysh..hss...pphhhhsssascs.plhshhpsuhusphps...ppuRsslppphusl.h......pshsshssRFPss.s.........h....hVhhhssslcsllssLhsuhD..T+NRhhEscs.t.....sPssuEs.s.....sTpts-D......uol.Al+sslspLhstLhp.t.....pshaspspFE....................................	0	1	1	4
+4654	PF00229	TNF		TNF(Tumour Necrosis Factor) family 	Finn RD	anon	Prosite	Domain	\N	20.90	20.90	20.90	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.70	0.71	-4.57	52	1178	2012-10-01 20:41:10	2003-04-07 12:59:11	13	10	195	271	481	1150	10	120.10	23	49.88	CHANGED	LpWppst...tshhtsGhphpssp..LllspsGlYalYoQlhFp........tsstt.................h.lshtlhhhssph....sp.hsLlpuhc.sssptts..........hhpslYhGulapLppGDclhlp..ss..p.shlchs..sspoaFGsatl	............................W.tt......h.h...p..shph.p..ssp....Lhl.psGlYalYuQVhFp........ts.tt............................t.h.lsttlhphssth......sp.ph...sL..hp.shp..ss..s.pt..ts...............hhpoh..ahG...G.lhpL.c.pGDcl.lp...ls......p.phlpht....tstoaFGhhhl...............................................	0	63	98	204
+4655	PF00020	TNFR_c6		TNFR/NGFR cysteine-rich region	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.07	0.72	-3.89	37	2327	2009-01-15 18:05:59	2003-04-07 12:59:11	13	54	156	88	889	2043	25	38.90	30	15.97	CHANGED	Cpps..pYpc...ps...t.C..C.shCps..GphhhpsCst.spsT.hC	...................C.ps..pY...ps.......sh....tpCh.C..spCss....uph.hh..psCos...spso..hC..........	0	184	248	442
+4656	PF01107	MP	Tobamo_MP; 	Viral movement protein (MP)	Finn RD, Bateman A	anon	Pfam-B_815 (release 3.0) & Pfam-B_1906 (release 4.1)	Family	This family includes a variety of movement proteins (MP)s. The MP is necessary for the initial cell-to-cell movement during the early stages of a viral infection.  This movement is active, and it is known that the MP interacts with the plasmodesmata and possesses the ability to bind to RNA to achieve its role [1]. This family also includes consists of virus movement proteins from the caulimovirus family. It has been suggested in cauliflower mosaic virus that these proteins mediated viral movement by modifying plasmodesmata and forming tubules in the channel that can accommodate the virus particles [2] and references therein. The family contains a conserved DXR motif that is probably functionally important.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.83	0.71	-4.92	18	493	2009-01-15 18:05:59	2003-04-07 12:59:11	13	31	165	0	22	530	0	167.20	20	27.73	CHANGED	hpplchs-...hlsLsps-phhs..shhpthKpshh++schlhsl............ppsculsplsLlsps.hp..........ctpchsal+luulhlslcsph.cshcsslplsLlDsRh.pstc-.uhlusacsshshtchtFplhPpYulShpD.slc+shplhsphcsls.MccGspPholcassshtloNSphslsh+phhssl	...............................................................................................................h..................p.h.............p.h......pp..hhhs..................tpspth..lsllpt........................ptpphsa..lHlusl.lshchh.h...p......sh.ssshtlsLhDsR.......h..tp...hc-...u....hlushpsshsps.p.hhh.p.h.hPsaslshpD.shppshplhlphcshp.hptGt..psholpht.hh.hhhs...s.h...........h.......................................	0	0	15	18
+4657	PF04052	TolB_N		TolB amino-terminal domain	Bateman A	anon	Bateman A	Domain	TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.14	0.72	-3.96	174	1688	2012-10-01 20:48:06	2003-04-07 12:59:11	8	19	1656	15	404	1275	1658	103.20	37	23.83	CHANGED	lpIcIop.GsspshPIAlssFt...spsss........thspplupllssDLppSGhFpslstsshhppstp....sspspassWpslsupullsGpls.ttsss...hplpacLaDlhp..sppl	.........................................lcI.Isp.GsssshP.IuVl.PFp........htuss............hPpcluslluuDL.cp.S.GpFsP.lspuphsppsss..........spplphss.W.p.u..l....G.h-A..lVsGpVs...s..scG..papVsapLhDs.tt..............................	0	106	226	315
+4658	PF03349	Toluene_X		Outer membrane protein transport protein (OMPP1/FadL/TodX)	Mifsud W	anon	Pfam-B_3708 (release 6.5)	Family	This family includes TodX from Pseudomonas putida F1 Swiss:Q51971 and TbuX from Ralstonia pickettii PKO1 Swiss:Q9RBW8. These are membrane proteins of uncertain function that are involved in toluene catabolism. Related proteins involved in the degradation of similar aromatic hydrocarbons are also in this family, such as CymD Swiss:O33458. This family also includes FadL involved in translocation of long-chain fatty acids across the outer membrane. It is also a receptor for the bacteriophage T2.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.48	0.70	-6.11	22	2710	2012-10-03 17:14:37	2003-04-07 12:59:11	11	6	1716	33	577	2172	277	395.70	23	92.57	CHANGED	sshssstshAuuh.hst.usuul.uRAhuGpuuhtc.ssushhpNPAshshhcp..sp..hphGhshlssc.lchpssssstph......................tstsssssshhlPphthlh....s-pauaGhulhsshGluocass.sahups..............huspocLtsls.lshusuY+Vs...cclSlGuulshsaspsplpp.......hhs...........................shsshsss...s.sssshhthts-shuhGaplGhhachsc.ssplGhsYpucs+h.chcGphshshssuhhs.h........................shsGplpl...plPsthpluhhHph.s-paslthshphstWSshpcl.........thtts.....tst..hshshs.sa+DshthulGssYphssphTlRuGhsYcpsshsspp.tsshlPsscppa.hShGhoYshs...ptslDhuauahhtccsshsp.s................sshshp.spssshlhulshshpF	........................................................................................................................................................................................s....ss.s.uu.uat.l.tp.......os.s....uh..up..A.hu.Gtus.h.s.s.s.A.u.sh...h..NPAhhshhcp.....sp.......hssuhs..h........l..pss.......h..p...h..p..s..s..s...s..s.t..t.t.................................................................................................psts..h..ss.s..t...h...l...P..s.h......a..h.s..h...l..........s-.p.......h...s..h.G.h.u..h.h..s...s..a.G..h.s.o...-....a...s..s.....s..hsu..t.............................................................................................hu.s.p..s..sl..p...s......hs......l....s.....sh..u...Y.....+...l..s.........p.phShGhGhsh..h.a..s.p.up.lpp............h.s..............................................................................................s..shs......sss...st.h.....s....p...h...p..us....s.hu.h..G..a..s..hGh..h.a..c..l........s...c....s......t..R..h....GlsY+S....clc....h...ch.c...G.s.hs....t..h.......s..h...t.................................................................................s.s.u..p.h....s.l.......slP..phhplus....hpp..l....ssp.h.......sl..phshpaTsWS..p..appl..................................ps.p.s.......................t....sh....h.p..t.p.t.......ta.c.D.sa....phu.lGs.....s..Y.......p.h...........s...c.......p.h...........s..hR..s........Gl..........ua..........Dpo..........shs..........s............p...............p.....t...............s...............h...............p.............l............P........c..............s....-......R.h.........h.............hohG....ss..Y..p.hs........ts....h....slD......h.uh..s.a.h.h.t.p.p.s..p.h.s.p.................................ssh..php...ps.p..s....hhuhphshtF...........................................................................................	0	153	342	479
+4659	PF04281	Tom22		Mitochondrial import receptor subunit Tom22 	TIGRFAMs, Finn RD	anon	TIGRFAMs (release 2.0);	Family	The mitochondrial protein translocase family, which is responsible for movement of nuclear encoded pre-proteins into mitochondria, is very complex with at least 19 components. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins.  This family represents the Tom22 proteins [1].  The N terminal region of Tom22 has been shown to have chaperone-like activity, and the C terminal region faces the intermembrane face [2].	28.70	28.70	28.90	28.70	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.90	0.71	-4.64	30	269	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	232	0	191	247	0	117.40	30	76.41	CHANGED	M.VcLTEVcDEshp........t..hsptpstttss.s-s--.o-s-SDh.sD..-.D........-sETlh-RlsALKDIlPPppRppIusthusssohh+oshshuGphlWsloTSALLLGVPhALAlhsEpQllpMEK.EhshQcsAs-.lLAP	..............................................................................................t.pcs-p-h.pp...-..D.p.........cETlhERlhuLp-hhPspsRpthusshs...tssshspshhpaoupuhWlhoTSuhlLslPlshth.....t...EpphhpMEp.p.p.hppt........t.........................	0	55	92	147
+4660	PF03220	Tombus_P19		Tombusvirus P19 core protein	Mifsud W	anon	Pfam-B_2714 (release 6.5)	Family	\N	25.00	25.00	26.80	299.80	21.40	15.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.19	0.71	-4.91	4	59	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	3	0	44	0	172.00	83	99.71	CHANGED	MERAIQGsDAtcQAsuERWDGGsGuohoPFQLPDESPohcEWRLHpsEpsscpDpPLGFKESWuFGKVVFKRYhRYDhpEsSLHRsLGSWpGDoVNhAASRFhGVsQlGCTYSIRhRGlSlTLSGGSRTLQRLlEMAIRhKho.LQLsssEVEusVSRGCPEusps...cESE	MERAIQGNDAREQANSERWDGGSGGoTSPFKLPDESPSWTEWRLHNDETNSNQDNPLGFKESWGFGKVVFKRYLRYDtTEASLHRVLGSWTGDSVNYAASRFFGhsQIGCTYSIRFRGVSlTlSGGSRTLQHLCEMAIRoKQELLQLTPlEVESNVSRGCPEGscsF.ccE..p.....	0	0	0	0
+4661	PF03544	TonB_C	TonB;	Gram-negative bacterial TonB protein C-terminal	Griffiths-Jones SR	anon	PRINTS	Domain	The TonB_C domain is the well-characterised C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane [1]. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.39	0.72	-3.78	109	5753	2012-10-03 21:09:15	2003-04-07 12:59:11	9	80	2084	10	1601	5569	1848	76.60	24	29.38	CHANGED	ht.pYPppApppsh..pGpVhlphslsssGplps.hpllpuss..t.hL-cuAl.cslcp...hpatPthts.sp...slshph...slpFp...L	..........................h...pYP..tt.At.p.t.th....pG...p...V..h..l..phs.l.s..t.s.G.......p..l..p..........s....l........p.......ll....p............u...s..................s..........s...hlDc..tAl.c.slcp.....h+.....ap.Pshts..Gp......sl.p.hhh....sltFp..................................................	0	574	1099	1396
+4662	PF00593	TonB_dep_Rec	TonB_boxC; 	TonB dependent receptor	Bateman A, Yeats C	anon	Yeats C	Family	This model now only covers the conserved part of the barrel structure.	16.60	16.60	16.60	16.60	16.50	16.50	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.66	0.70	-4.48	666	34093	2012-10-03 17:14:37	2003-04-07 12:59:11	19	67	2349	66	8506	31731	11867	284.70	12	36.18	CHANGED	sPphul......aphss..............shslhu..saupuacssshsphh..............................................................................................................hssssLcPEpupshElGhchphts..........hphshsh.aptchcshlstsssssshsstsstttttttttttstttthththhtththhhh............................................................................................................................................................tttssttststtsthhtttsthhtththtttthtththshshthsspttsssssshph..suashh-ht.ssY.phspt................hplphs...lpN...Lh..........s.cpYhthhs.t.........................hhh.u............................................sR.shhhslshp	......................................................................................................................................................................................................................................................................................................................................................................................................................................sphuh......ap.hsp..................................phplhs...ua..up..s..h..p...s.....s..s..h..tp..hh....................................................................................................................................................................................................h...ssssL....c....s...E....p.....u.....p...s.....h...-lG...h...c..h..p.hh..s...............................hphs.......hs..h..a.p.p..c.....h.....p.....s....h........l......h.......t......s.......s.......s.....s...........s.......s.................s.....h.......t......s.......t.......t.........t.........t.....t....s...t...h.......t......t.....t..t...h...t.........h..h..h..h...t.h..h..h..t..t...t...t...t..h...h..h.....................................................................................................................................................................................................................................................t.t.t.t..t...t.t..t..t..t..t....h....t....h......h....t....h...h...t.....h....h.....t.........h.....t.....h.....t............t..........h...t........t......h....t...........h..........t....h........t.......h...........t......h......t.........s........t.........t...........h....s........s...........s......t........t.....h....h...p..h................s.......s........h.........t....l....h.s.lt.....hs..Y...phspp..................................................hpl..t..hs.....spN.........Lh.....................s...p..ph.h.t...ht.t................................................h.s.................................................s..R..s..hhhshph....................................................................................................................................................................................................................	6	2644	5782	7351
+4663	PF01131	Topoisom_bac		DNA topoisomerase	Finn RD, Bateman A	anon	Pfam-B_505 (release 3.0)	Family	This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax  negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.	23.10	23.10	23.20	23.20	22.70	23.00	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.60	0.70	-5.65	126	9972	2009-01-15 18:05:59	2003-04-07 12:59:11	15	124	5053	35	2152	8171	4882	388.60	29	56.06	CHANGED	chshsLspAthsRphhDhllGhslSp.hh....s..........t.....tsl.SsGRVQoPsLthlV-R-cEIcsFh....sp...a..aplp...sp.............h....................ttthh..............................ttpptphhscp..pApphhppl.p.............t......lp..plcpccc..pp.ssP.PashssLQpcAspphu.houpcshplAQpLYE........p.G....lIT..YPRTDSphls.ps......s.hpthhphlpp..t......hhs.....h.th...tp..........stp...sAHcAIhPTtshs.......sphs..........cctp.........lYcLIhcRalAs......hhssshhppsplpl...t........tt.........FpspGppllp..tGaptl...h.........ttpppp................lP...lpp...Gch...........l.h..tp.p...h.tcpTpPP.spaoEuoLlptM-pt.........................GlGpsuThAsIIppLh...cRtYlppt....p.pt...lhPTchGhtlh.chL.......p....h...p..lssschTuphEppL-pItcGchs.hpphlp	.....................................................................................................................................p...hsLssAt.ARphhDhllG..hs.h.S.hl......p..................................................p..ptsL..Ss..GRVQossLt.lllcR-..cEIcsFh......scp.....a.....aplpup........h..................pttttp..................................................................hptpphch.h..s.cp......psp..t..l..h.....p.t..lps......tt................hpVp.pl.pp.Ktp..............pp..tsPhPash..o.oLQpcAup.+hs..au......s....ccThpl.......AQ.pLYE............p.t.....hI..........T..Y.RTDSph......l...spp......u.hp.t.shph.l..t..p..p..h.st....................pahs....h....p....h..h..t..t..t.......................pssp........pAH.cAIhP...T.tth................tphs...................................................pppt..plYpLIhp+alAs..h.s.s.uhhcpsslpl.......ph...................................st.hp....F..p..u..p..G.ph.lh...t..Gahpl.............h...........tttppppt.t.........................................................LPt..lppG-t.............................................lph......tp..hp.......pp.+h.TpPP.s+aoEAoLlp...t...h.Eph........................................GlG........p.......suTh......AslIpsl..........c.R....t........Y........lph.............p.+p.........lhsTphGhhlhphl.......p.............................p...........lhs.......p......hTAp....h.....EppLcpI.tp...Gphphpphl............................................................	0	747	1386	1825
+4664	PF02919	Topoisom_I_N	Topoisomer_I_N; 	Eukaryotic DNA topoisomerase I, DNA binding fragment	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1377 (release 3.0)	Family	Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2]. This family may be more than one structural domain.	25.00	25.00	25.50	26.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.37	0.70	-5.05	47	487	2009-01-15 18:05:59	2003-04-07 12:59:11	10	10	324	17	282	471	28	203.10	51	28.20	CHANGED	hKWpoLcHNGVlFPP.Yc.LPcsVKhhY-GcslcLsscsEEVAsFaAshL-o-.aspp.sFp+NFFpDF+chlscpttt............IcchcKCDFophapaappp+....EpKKshocEEKK........tlKtE+-c.h-c.YtaCllDG+.+E+VGNFRlEPPGLFRGRGpHPKpGpLK+RlhPE.DlsINluK-u.lPpPP....sGH.+WpElpHDNoVTWLAhWpE.NIssp.hKYVhL	................hKWppLEHpGslFsPsYc.LPcsV+hhY-GcslcLssc.sEEVAoFautM.L...-.......p.....-......Y....spcthFpcNFFpDa+.c.hsppptt...................hIpshpKCDFs.hapaaptpp.......E..t+.......K..sho+E.....EKp.......................tlKpEp-c.hpppYtaClhDG+.+E+lGNF+lEPPGLFRGR.G-HPKh.....GhLK+RlhPE.DlsINhu.....K...........-utlPpPP...................sGH.+WKEV+HDNpVTWLA.WpE.NIpss.hKYlhL..................................	0	94	151	229
+4665	PF01028	Topoisom_I	Topoisomerase_I; 	Eukaryotic DNA topoisomerase I, catalytic core	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1377 (release 3.0)	Domain	Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination [2].	20.90	20.90	20.90	20.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.56	0.70	-5.26	134	1273	2012-10-02 14:09:14	2003-04-07 12:59:11	15	15	1066	23	472	1266	171	214.00	37	46.11	CHANGED	tDucsRpQYhYt...a.t.+-tpKac+hhchtptlsclR.cplpc-L..........psthsc.c+.lAsslhLlD................phhlRlGs-cYsc-st.ohGhsTLRscHlp.lps.............................................................................s.tlpFcFhGKsulcaphplc....Dpplh+slpth...........p...chPGpcLF.............cpls................................osclNpaL+chh..........ts.........hTAKsFRTasuolthhpt.....Ltph...................................................................................................t.....shsptppthstus+pVAthlspT.ul.s+ppYlpspllp..thtt..t.h...tthtph	....................................................................sph+tp...........ps.tKapphhthtphlstlR.tthptph.................ttt..t....p..hAshhhhl-.........thhlRsGspp.tpcpt....o...hGhsoLRscHlp.lpt.............................................................................p.slhFDFlGKDu.I+ahscVt...........h-.....c...+V..aKsLphhh............cs...KtPG--LF.............c+Ls................................oshlNcaLp.clM......ps...................lTAKsFRTYsAS.h.Thtpp.....Lpchs..............................................................................................................................st..s..shsp+hhshscAs+tVAhlssH.p+uV.s+.s..phhphphLptthpt..............s.................................................................................................................................................	0	137	260	379
+4666	PF01751	Toprim	Primase;	Toprim domain	Bashton M, Bateman A	anon	Pfam-B_500 (release 4.2)	Family	This is a conserved region from DNA primase. This corresponds to  the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1]. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely  abolish DnaG type primase activity [1]. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division [2]. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases [4]. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-4.03	136	24868	2012-10-01 21:47:57	2003-04-07 12:59:11	17	150	8181	82	4223	22716	8361	107.80	31	17.30	CHANGED	plhlVEusscstslpphhs..................................htlhsshGphhsh.p...........................................................lptltphh.............................................phpclllssDsDp.....-Gpplshplh.phhtthh..........tchhhspl	............................................................................................................................................................................................pLhlVEGcS.s.u.soh...cpuhs..............................................pp.psllsh....+G+..l.l.N.lpc.sp...hsc........................................................................................................................................................hhpspplpsl.hpsh...........................................................................hc..h..c..cl..llhoD..sDh.............-Gt.tIthhlh..phhht...h............thlhht..................................................................	0	1416	2671	3539
+4667	PF01533	Tospo_nucleocap		Tospovirus nucleocapsid protein	Bateman A	anon	Pfam-B_950 (release 4.0)	Family	The tospovirus genome consists of three linear ssRNA segments, denoted L, M and S complexed with the nucleocapsid protein. The S RNA encodes the nucleocapsid protein and another non-structural protein [1].	19.80	19.80	22.00	60.50	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.54	0.70	-5.14	11	1122	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	38	0	0	714	0	238.40	61	94.92	CHANGED	MSps+.lTccpIpcLLsuuct-VElEp-psphuFNFKsFapsNps.lc.hohssslohLKsRppIhtssKpucas.FsshsIlto...SspVus..sDaTF+RL-uhIRsKhlptl..ocNscsppchhsKlhshPLVpAYGLp..uhhDtsulRlhlhlGGsLPLlASlcohtshuhsLAhYQssK+EpLGI..ppFsThEQLsKVspVhpupuhphscs.cchhcphscILssssPsspGuh..uhc+YsEplpthtss.F	....MSpVK..LTKEsIVsLLTQG+.DlEFEEDQNhlAFNFKTFCLsNLDpIK.KMSlhSCLTFLKNRQSIMKVIKQSDFT.FGKITIKKT...SDRlGA..sDMTFRRLDSLIRVRLVEE......TsNuEsLsoIKoKIASHPLlQAYGL...PLsDAKSVRLAIMLGGSLPLIASVDSFEMISlVLAIYQDAKa+-LGID.KKaDT+EALGKVCTVLKSKuFEMsEDplKKuKEYAsILSuSNPssKGSl..uh-+YsEplshh.phF...	0	0	0	0
+4668	PF00087	Toxin_1	toxin; toxin_1; 	Snake toxin	Eddy SR	anon	Overington	Domain	A family of venomous neurotoxins and cytotoxins. Structure is small, disulfide-rich, nearly all beta sheet.	20.70	20.70	20.70	20.80	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.12	0.72	-3.60	48	594	2012-10-03 01:43:02	2003-04-07 12:59:11	16	1	92	141	6	666	0	60.80	38	79.57	CHANGED	hpCapp.s....socTCP.tGpNlCY.K......pa.pc...p..+Ghh.l-RGCusoCPpscs.hhplpCC.sT.DcCN	..................................pChpp.t...s.sscoCs.sGcshCYp.K......tapc..........p.ps.hh..lcRGCu.s..sC..Ppscs.....thpl.......p.CCsT.DcCN......	1	3	3	3
+4669	PF00451	Toxin_2	toxin_2; 	Scorpion short toxin, BmKK2	Finn RD	anon	Prosite	Domain	Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity [1].	25.10	25.10	25.30	25.40	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.28	0.72	-3.86	48	130	2012-10-01 23:31:40	2003-04-07 12:59:11	14	1	40	50	1	165	0	31.00	44	65.14	CHANGED	lcCssopcCht.sC+chhGpttG.KChNsKC+CY	....l+Csuopp.Chp.sC+cthGhttG.KChNs+C+Ca.	0	0	0	0
+4670	PF00537	Toxin_3	toxin_3; 	Scorpion toxin-like domain 	Bateman A, Moxon SJ, Finn RD	anon	Pfam-B_8170 (release 8.0)	Domain	This family contains both neurotoxins and plant defensins.  The mustard trypsin inhibitor, MTI-2, is plant defensin. It is a potent inhibitor of trypsin with no activity towards chymotrypsin. MTI-2 is toxic for Lepidopteran insects, but has low activity against aphids [1].  Brazzein is plant defensin-like protein. It is pH-stable, heat-stable and intensely sweet protein [2]. The scorpion toxin (a neurotoxin) binds to sodium channels and inhibits the activation mechanisms of the channels, thereby blocking neuronal transmission. Scorpion toxins bind to sodium channels and inhibit the activation mechanisms of the channels, thereby blocking neuronal transmission	21.50	21.50	21.60	22.00	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.76	0.72	-4.09	33	487	2012-10-01 23:31:40	2003-04-07 12:59:11	13	1	55	78	15	598	0	53.00	38	69.05	CHANGED	+D.....uY..Is.pscNCsYpC.....h.h..ssaCsshC+c.pGAcuG.aChahu...hs.ACaChsLPDss	................+-GY....ls..pspsCthpC........hh...ssaCs.p.C........cp..pGup.s....G.YChhhu..........tCaC.sLPDp.......	0	7	7	7
+4671	PF00706	Toxin_4	toxin_4; 	Anenome neurotoxin	Bateman A	anon	Pfam-B_589 (release 2.1)	Domain	\N	20.90	20.90	21.80	21.60	18.00	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.40	0.72	-3.75	7	75	2012-10-01 20:50:19	2003-04-07 12:59:11	12	1	27	7	9	95	0	43.60	56	70.66	CHANGED	sChCDsDGPslRssshoGTl...huuC...suGWcpCtuhhssIu.CC	.sChCDSDGPslRGsoLSGhl..Wl.......uuC...PSGWHpCpuptshlu.CC	0	9	9	9
+4672	PF02079	TP1		Nuclear transition protein 1	Mian N, Bateman A	anon	IPR001319	Family	\N	25.00	25.00	68.00	67.90	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.79	0.72	-4.20	3	42	2009-09-11 05:49:06	2003-04-07 12:59:11	11	1	36	0	15	30	0	52.00	85	95.33	CHANGED	STSRKLKSHGMRRGKNRoPHKGVKRGGSKRKYRKSSLKSRKRGDDANRNYRSHL	.STSRKLKSHGMRRGKNRoPHKGVKRGGSKRKYRKuSLKSRKRuDDANRNaRSHL.....	0	1	1	2
+4673	PF01254	TP2		Nuclear transition protein 2	Finn RD	anon	Prosite	Family	\N	25.00	25.00	51.80	51.70	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.11	0.71	-3.83	4	40	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	25	0	12	46	0	124.20	61	99.72	CHANGED	MDTKTQSLPsTHsQPHSNSpPQSHssppCuCS+HCQopSQS.....pssRSpSSSppPtuHR......S.sG+QSQSPuPSPPs+++K+sMHSHpsPSRPso+pCSpsKNRKNLEGKlpKRKtlKRppQVYKsKRRSSGRKYN	..MDTKTpSLPlTHTQ.HSNSpPQS+T...st.CsCo+HCQohSQSCppupps......SpSRSSSQSPsuHp........SsoGpQS..QSPssSPPPK+HK+TMpSHHuPsRPThh+sSCPKNRKNLEGKlpK+KhsKRhQQVYKTK+RSSG........	0	1	1	1
+4674	PF04406	TP6A_N		Type IIB DNA topoisomerase	Waterfield DI, Finn RD	anon	COG1697	Domain	Type II DNA topoisomerases are ubiquitous enzymes that catalyse the ATP-dependent transport of one DNA duplex through a second DNA segment via a transient double-strand break.  Type II DNA topoisomerases are now subdivided into two sub-families, type IIA and IIB DNA topoisomerases.  TP6A_N is present in type IIB topoisomerase and is thought to be involved in DNA binding owing to its sequence similarity to E. coli catabolite activator protein (CAP) [1]. 	20.50	20.50	20.50	20.80	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.02	0.72	-4.31	65	534	2009-09-14 12:29:41	2003-04-07 12:59:11	9	9	417	7	349	531	120	69.40	27	18.33	CHANGED	shp...psp+.....hsphhhllphl.pctlppsphs.ThR-lYYpspp................hF.ss........QspS-pll-Dlph.hhsl..REphplh	..........................t..tpsp+hsthlhllphl..hchlp.p..sphs.Th.....R-lYYpshp.................hF.ps........Q....sps.DpllcDlsh.hl...tl..sRpsLpl..............................	0	105	197	287
+4675	PF00590	TP_methylase		Tetrapyrrole (Corrin/Porphyrin) Methylases	Bateman A	anon	MRC-LMB Genome group	Domain	This family uses S-AdoMet in the methylation of diverse substrates.  This family includes a related group of bacterial proteins of unknown function, including Swiss:P45528.\	  This family includes the methylase Dipthine synthase.	27.30	27.30	27.30	27.40	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.45	0.70	-4.63	171	17348	2009-09-13 05:43:58	2003-04-07 12:59:11	15	82	4907	229	4809	13595	4640	206.00	21	64.04	CHANGED	plhllGhGsGs..s.-hlThcAhchlp.pA-ll.....h....sss....................p......shphl..h....................................t........hphhpts......................hpphtchl..htthppstt..Vshls.sGDPhla..uhsthlh.t..hlttt...h....hc..llPGlSohpsssuthuhshs.psthhphhh...............s.t..ttthhpph.t...........sslllh........hsst..t.......htplhphL...........hpt...........p.tlhlscp.....huhs.s.Ep..lh.psslppls	.............................................................................................................................................................................lhlVGsGs.Gs........p...h...lTh..+uh...........ch...Lp...pA....Dll.....................hhcs.............h......ssphl.hphh......................................................................ttt............ht.hh.phs........................................................................tpch.s.p...h..h........l..p..t.h.p.pG..pp......Vshls..uGDPhla.......uhutc.hl.p...........th..t....p...............t...s...lt....................hp......l..l..PGloushuu..sut.....s.....Gl....s.hs.....t.h...h.pslh....................................thtt..p..pt.p..hp.t.h.ttt.......................t.pol..l.hh...................................husp...p......................lsplh.p.tL......................................................hpt...........s.pp.lsl..s.cc........ho.ps..p.pp..lh.pssltph................................................................................................................................	0	1545	3155	4100
+4676	PF04201	TPD52		Tumour protein D52 family	Bateman A	anon	Pfam-B_2632 (release 7.3)	Family	The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family [1]. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other [1].	25.00	25.00	29.60	28.80	24.90	23.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.06	0.71	-4.51	4	406	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	101	0	173	372	1	162.90	44	79.83	CHANGED	uLlhspshsEsstshssohsuo..sLSEtEp-EL+sELsKlEEEIpTL+QVLAAKEKHhuElKRKLGhsshsEL+QNluKSW+DVpsTsAYh.........tQKsosAhuuVGosIs+KhsD..................h+NSsTFKSFEpKVto....lKo+VuGs+.sGus.hsclluuusssSAp	...............................................................h..s....t....p.s......LoE.pE..p....E....E....L+....t....E....LsK.V...EEEIp..TLRQVLAAKE+HhuE.lK.RKLG........losLpELKQNlu...+uWp.DVpsosAYp+TpE...............................................TLSpAGQKsSAAh....S....slGosIo+KLsD...........................................MRNSsTFKSFE-+Vts....l..KoKVs.usp.ssss.h.p..t...........................................................................	0	40	50	92
+4677	PF00205	TPP_enzyme_M	TPP_enzymes; 	Thiamine pyrophosphate enzyme, central domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The central domain of TPP enzymes contains a 2-fold Rossman fold.	27.90	27.90	27.90	28.00	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.75	0.71	-4.41	309	15120	2012-10-03 09:55:27	2003-04-07 12:59:11	17	40	4534	251	3745	11432	6158	134.60	28	23.53	CHANGED	lppssphlppAc...+P..lllsGuGshhs.p..Apppltplu-ph.slPV.ssThhG..+Gsls.p..........sc................Ph....hG.hhGhh.u.....stsustsl.pp..uDlllslG.sc...hsp.hs......hs..phs.tassp........s..p.........l..lpl.D......................l-s.........scls+sh.............ss.lsllGDsp.......tsLptL	.........................................lpcshph.l..p..p..A.c...+P...l.lhsGuGs...h..s...p.........A.s.p.....p.L...p...c...hs-ph..plPl...s.s...T..h.hG...t.Gs..ls.p............................s.c...................Ph.h...lG..hh....Ght.G......st.su..s.h.sl...pp....uD..l..l..lslG.sR...as.c..ps..tu..........tht..tassp.......s...c.........l..lp.....lD.......................l-s....................sp.l.s.+.hh..........t...sc..lsll.GDsp....tsLpt...............................................................................................................................................	0	1002	2186	3051
+4678	PF02775	TPP_enzyme_C	TPP_enzymes_C; 	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	Finn RD, Griffiths-Jones SR, Mistry J	anon	Prosite	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.08	0.71	-4.64	327	23243	2012-10-02 16:07:47	2003-04-07 12:59:11	16	110	4932	295	6025	21857	10671	146.80	22	24.62	CHANGED	-lGptph.hhtph.......t.spp.als...ss...shusMGhulPsAlGsp..l....s........s..t.....t.pVl.slsGDGu..ahhs.h.pELtossph..sl.slhlllhNN.phhGhlctt...pp.hhhttphss.p...............hts.DastlAcu.h..Gsp.uh...p.lpsh..pcl...ppslccA...h......ppptPsll.-l	........................................................hGp..h.....................stp..hhs......ss........shus..h..G..h.u..l....ssAlGsph................u...........................p.P.....c.....c..pVl..slsGDGu....h..h..hs..h..p.-..L..s..............s.....s.h...p.h..........sl....s..l....t.....l......ll.l.N.N....p..s.....h....u...h..spt.................pp..hh..h.t..t.p.h..s..s.......................................tth...D..a...s..t....l.A.......pu.h........Ght...sh................pl...p.....s.t..............p.c..l.......pp....s...lpcAh........ppss.ssllch.......................................................................................................	0	1846	3761	5012
+4679	PF02776	TPP_enzyme_N	TPP_enzymes_N; 	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.87	0.71	-4.77	118	17953	2012-10-02 16:07:47	2003-04-07 12:59:11	13	63	4635	275	4426	14362	7899	169.30	28	30.25	CHANGED	hssuchlschLpp.hGlcp...............lFGlsGsphhs.lhcultpt.......tlphlhs+cEpsAuhhAs..uau+..ho.Gc.......sulshsss.GP.GssNslsulssAhts.phPllhlsGpsstpths.........tthhp.ph..D.thsh.....hp..shs.Kh......shplpsssphsphlpcAhptA..hssptGPVhlslPhDlhttpssts.	..................................................................................h.psuphllcsLpp..p..G..V..c.p......................lFG.hP...Gu.shhs..lh-u...l...tppt....................tlc.al....h...sRHEp..........uAuahAp....GaA+.......ho..Gc...........................sG..V.s..lsTS..GP.G.s.s........N..hlsu......lss.A.h.h.-....sl..P...l.lslo...G...pss.sshls.............................pss..aQ.ph..........D....hhsl.........................hp.......sh.s...+a.............................shh.l......p......p......s......p........p.......l......s.........p.........h.......l.......p..............c...Ah.......phA......................s........ucsGPVhlslPtDl..t.h....t.....................................................................................	2	1202	2609	3623
+4680	PF01963	TraB		TraB family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	pAD1 is a hemolysin/bacteriocin plasmid originally identified in Enterococcus faecalis DS16. It encodes a mating response to a peptide sex pheromone, cAD1, secreted by recipient bacteria. Once the plasmid pAD1 is acquired, production of the pheromone ceases--a trait related in part to a determinant designated traB. However a related protein is found in C. elegans Swiss:Q94217, suggesting that members of the TraB family have some more general function. This family also includes the bacterial GumN protein. The family has a conserved GXXH motif close to the N-terminus, a conserved glutamate and a conserved arginine that may be catalytic. The family also includes a second conserved GXXH motif near the C-terminus.	30.20	30.20	30.30	30.20	29.70	30.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.65	0.70	-4.94	137	1980	2009-09-12 01:14:50	2003-04-07 12:59:11	12	13	1569	0	659	1576	259	253.30	21	77.55	CHANGED	hlWclp.....ps.s......pp.........l.................aLlGThHlsctsh..lsstlpphhppu-slslEh...................thhh..s..spplp.shlsscphpplsthhttht..hs.....phhpphcP.hhlshtlshsthpp............thssp.....Gl-.thtttAt.........tpstphhs....LEshchQlshh.psh...shpp....phphlhpsl......pp.h.....tpt.sph..hpp...hlpt.atpuDh....ptlhph.........htp...........thsph.hcsllscRNpt....hspplp..phhppt...........tthhssVGAuHLsGtpu.....................................ll.................................shLpttGaplpth	.................................................................................................................................................s..s.....pph.....aLlGohHh.u.sp.sh.t....s....l....ss....tlhpthppuDslhlEh.....................................h...........s......stsl.p.phl..st.c.p.hp..pL.pph.....p..t.h....hs............................phhpph...a.ls.hh.lt.....htp.hpc.........tlpsph.......Gl-h.th..ttAt..............tppt.hht................................LEstp..Ql.shh...pth.........................s.tt....t..ht.hLts.sl.....................sp..h.....................pss...sch.........hpp.........hhph.ahp.s.s........sshhp...............................hpp.................ht..p.l.hc.s.LlpcR.Ntt......hspplp......th.ttp........................hlssVGAhHLhGt.ts............................................................l..................................................................phLp.......................................................................................................	0	225	409	534
+4681	PF02534	T4SS-DNA_transf	TRAG; TraG;	Type IV secretory system Conjugative DNA transfer	Bashton M, Bateman A, Staddon J	anon	Pfam-B_1146 (release 5.4)	Family	These proteins contain a P-loop and walker-B site for nucleotide binding. TraG is essential for DNA transfer in bacterial conjugation.  These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems [2].  The C-terminus of this domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore [3]. The family contains a number of different DNA transfer proteins [4].	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.47	0.70	-5.91	9	2504	2012-10-05 12:31:08	2003-04-07 12:59:11	9	20	1333	0	409	3978	356	393.00	19	69.09	CHANGED	passhs-hpptt.hhpctshlhs.h.ths..................hGt...hhstsGpF.........ashlhAsotuhKusullIPshLsasp.olVVhDPKuElaphTuphRcppup.cVhlh-Ptsspsp..paNPlDaIsttss..stscDlhtlsshlhsspsh..........................c-aapssAtpLhsul.............hhhhphpstscshstslphlpshtu-.......csh.hsphhpphpssctststpslushhspsc.............cphoSVhushsuphphassP.lpshsStSDFslcclt..cccsslalslsspshphhsslhplhhp.hhphhtpp.sshctp.ht.....sLFlLDEFspLGhhchhcpuluhhttYslplhhIhQoluQLps....tYsppsApohlsspsshlsaussN....-TAcaISchlGptTlchcssSc.....ssspuso+opohs.spRsLlpPcElhpMssccp............IllhpupsPl+scKshYacc...........................pphpsphsc.t.hhstphthu	.............................................................................................................................................................................................................................................................................................................................................................tth.hl.hus.o.tSGK..s.....h...s...h.....l.....h....P....s.....l...............h..........p.......h.....t........t.....S.......h.....llhD..K.......s.....-.......h...........h...........t........h..........s........u.......t...............h.........h.....p....p.......t.......s.......h......c.......l......h........l...hs........................h.................s................p...........p........u...................p.........a...........N.P..h.....t..........h...l.....p...p.....t..........tp........h.h.....s.....h.......t.........l..s..s...h....h...h..s...t.pt.........t.................................................................................t.c..sa.Wtpsup.t.L.hs.uh.........................................................hhh.hh..h..t...t.........t...........s.......h...s.............h.........hp...h....l...t......t.......h.........t....s.t.............................t..h.......h................h..........h..h.t..t.............h......t......t.............t.........................s.........h......h....h...t..t........h...t....t....h......t...t..s.t..........................................................................pphsulhss...h..ts..h...l.s.h......a.....t.............l......t...p....h.h..........s...........t....s.......-...........h.........c..l...p..p..lt..............pp......h........s........la.l.h..h...s...s.....p...p......s...h.............lh.......t..l.h.h..p............h...h.p...h........h.......t...p...t..................t...........t...t..........h....................hhhhh....DEhs.sl...G....h.....h...........h..tp..h..hu.........hhtu.......htlphhhlhQsh....s.Qlpt...................hY.t.p..t.t....h.p..sh..h....s.s...s....h..hh...h..s..tp..........psh..c..lS.p..h...h.Gp.....T....h............s.hs...............................t...................t....p..........s.........s.......p...........t....+....L...h.........tE.lh......h........t..t............................lh....h....t....s..............s.....hh...t..........................................................h..............................................................................................................................................................................................................................................................................................	0	134	274	337
+4682	PF00923	Transaldolase		Transaldolase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_787 (release 3.0)	Family	\N	20.90	20.90	22.80	22.20	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.71	0.70	-5.28	131	6718	2012-10-03 05:58:16	2003-04-07 12:59:11	14	21	4201	128	1447	4243	3165	256.10	30	91.25	CHANGED	lahDssshchIc.....chht...lpGsTTNPolht+......Ahp.....tpthhcctl....pphppt...................................................t.hh..lhh..h..hhthh..........sG.hVShEVss.hshDscuslpcA+cLhphhp........t.slhIKlPuT.....-GlpAhcpLp.pc.G...............IplNlTLlFShtQuhtsAcA.............G...........ssllSsFVuRlschh..........................tt.sGltsspphaphacph.s...................a.sTtlhsASh+sshplh..sLsGsctl.Tlssshlcphtp.csts..........................tt..t....hp.p.hh.ph.s-Glc...pFtpsappLhttl	................................................................................................lhhDTusl..ptl+..........chtt.....h.pGsTTNP.S.llhp........t..........hpt.h.c.-.sl.tphppt........................................................................l........................................sG.plSs.EVsu................h.Ds-shl.pc...A+cLhphhs.......................plll..KlPs.T..............................hp.Gl...pA...hchL...p...p.-..G.............................IpsNlT.............LlFShsQuhhsAcA..................G........sphlSPFVG.Rlt-hh..................................tsGltslpplhphacpa.s....................................h..pTtl.....hu.AS..aR..........ss.tplh.........tL..s..Gs..-h.......l..T.ls..sllpphhp..psts...........................t..ptl.......................................................................................h.....................................................................................................................................	0	481	911	1226
+4683	PF00382	TFIIB	transcript_fac2; 	Transcription factor TFIIB repeat	Finn RD	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.18	0.72	-4.16	12	2462	2012-10-03 00:42:12	2003-04-07 12:59:11	14	23	536	21	1522	2387	745	70.60	26	32.13	CHANGED	ls+hsspLcLsc...hVtcsAtclh+pshcpthlpGRSstulhAAslYlAsRhpphpRohpEIsslspVschol	...................................ht+hssp.L.s..Lsp........pltc...pAtpl...h.c....p...s...h............c...........p.............t...........h.....h......p......G...Rs...s...........pulsA..AslYhA.s..R.....h..p...s.....h..s.+.....o.hc.El.u.sls..p.Vschpl........................	0	455	879	1280
+4684	PF00405	Transferrin	transferrin; 	Transferrin	Finn RD	anon	Prosite	Domain	\N	20.30	20.30	20.30	20.30	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.08	0.70	-5.57	10	1389	2012-10-03 15:33:52	2003-04-07 12:59:11	12	15	229	250	465	1509	132	257.20	32	86.39	CHANGED	VRWCslSssEtpKCpsap-pM+pht...sPsloCV+KuSsl-CIpAIAssEADAlTLDGGhlaEAGLsPYsLKPVsAEsYGo+-pPpTaYYAVAVVKKuSsFplNpLQGKKSCHTGLGRSAGWNIPIG..lLcstLsWtG.spcslEcAVucFFSuSCVPGAcc.sthPpLCQLCsGputsK..CusSspEPYaGYSGAF+CL+DGAGDVAFVKcSTVhENLsscA-R........DpYELLChDNTR+PVD-YKsCHLApVPSHAVVARSsssKE-hIWcLLspAQE+FG+-pop-FQLFSSPsGt....KDLLFKDSAlGFl+lPophDStLYLGa-YhTAI+NLRc	...............................................................WCshup..E.t..KCttht.....t......................tlpC.ht.t.t..s..cClptIh.t.tcAD.sh...slD.u.s.la..A.u................h...tLhP....l.hs......E...h..........t....................................t..........t...................t........t.........t............Y...............h......u.VAVV.....+.....+.....s......s.......s....h.......p..............h..............p....p..................L......p........G...+...+SC..Hou.h..s..p.....s.A.G..W.p.l...Ph...u..........h..t........h..........................................................t....h...s..p...aFs.t.u.C.....s.......P.....G..........s.......p...................................................s....p.LCthCh.G.....................................t.........C..t..............s...t.p.-.Y..h.GasGA..h...........+...C.L.h-...s........t......G-....V.AFl....+..........p..........t...........s....l.........p...........s.....h..........t....s........p.............................................ppap......LLC.....s...s....s.....c...t..s......l...s.....p....a....p...p..CpL.u....ps.P.....s+uV.l.s...R.................................t.......l.h..p.hL....p..........t....t.................................................h..phFts........................psLhFpDss.th..h......................h...................................................................................	0	88	121	296
+4685	PF00868	Transglut_N	Transglutaminas; Transglutamin_N; 	Transglutaminase family	Bateman A	anon	Pfam-B_783 (release 3.0)	Domain	\N	21.40	21.40	21.50	21.80	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.47	0.71	-4.07	50	614	2009-01-15 18:05:59	2003-04-07 12:59:11	15	12	106	39	309	576	0	116.20	30	17.57	CHANGED	LplpsVDlpppp...NstpHHTccap..........spcLlVRRGQsFplpLphscs...apsstDplplhhphG..stPs.....spGTpsslsl....spttp......sssWsupltspsusp.....lplslpssssAslGcYp.Lsl.....pspst	.........................tlpplDh....p...pp...N..ptpHHTpcap...........................................spcLlVRRGQsFplpLphsps....a.sst....-plph.hp.s.G......stPs............spGTpsshsl........sstts......sssWsAtl...p.p..psps.......lslslpoPs.sAslG+YpLplpst.s..............................................................	0	56	87	169
+4686	PF00912	Transgly	Transglycosyl; 	Transglycosylase	Finn RD, Bateman A	anon	Pfam-B_558 (release 3.0)	Family	The penicillin-binding proteins are bifunctional proteins consisting of  transglycosylase and transpeptidase in the N- and C-terminus  respectively [1]. The transglycosylase domain catalyses the  polymerisation of murein glycan chains ([4]).	20.70	20.70	20.80	20.90	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.16	0.71	-4.96	172	12887	2010-01-08 14:08:55	2003-04-07 12:59:11	17	38	4268	62	2627	9890	3274	179.10	35	26.43	CHANGED	sG......t.ltth........tpp+phl.s.hs..............p.l...s.t.......lhpAllusEDccFap......HtGlDhtulhRA.hhpsl.t...sspht.......pGGSTITQQlsKs...h.hL..........p........p.....+o....h......pR...KlpEhhhAhpl......Epp..hoKccILch.YLNpl.h.G.p....ssaGlpuAuphYFuK............sspc..Lshs.....EuAhLAulhpuPs......ta....pP..h......p......scpspp....R...pshl.LppMh	............................................................t......ph........tppRhhV.s..hc................p..l.....sst.......lhpAllA.sEDp...+F.ac.............Ht.Gl.DhhulhR....A....h....hpsl..h................................su.pts...........pGGSTlTQQlsKNh..aL.................s.....................p-..............+o.............h....tR.............Kh.pE.hhl.A.lpl..................Epp....h.o......KccILph.YLNp.lah.G..p......ssaGlpsAAptYFG..K...........................sspc........Lols........................puAhLAGlsp.uPs..........tY.sP.....hp..s...................sctutp.........R..p.s.hV.LppM............................................................	0	760	1609	2146
+4687	PF00456	Transketolase_N	transketolase; 	Transketolase, thiamine diphosphate binding domain	Bateman A, Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	This family includes transketolase enzymes EC:2.2.1.1. and also partially matches to 2-oxoisovalerate dehydrogenase beta subunit Swiss:P37941 EC:1.2.4.4.  Both these enzymes utilise thiamine pyrophosphate as a cofactor, suggesting there may be common aspects in their mechanism of catalysis.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.87	0.70	-5.63	12	11328	2012-10-02 16:07:47	2003-04-07 12:59:11	16	27	4696	96	2755	11612	8619	262.80	31	48.34	CHANGED	.cpphsssIRhLuhDAVppApSGHPGuPMGhAslApVLapchL+psPssPpWhsRDRFVLSNGHuuhLLYuhLHLsGY.DLsh--L+pFR..QltS+TPGHPEhtassGlEsTTGPLGQGIuN...AVGhAlAp+sLAApaNcsGasIsDaaTYVhhGDGCL.EGlSpEAsSLAGpLpLGpLIshYDcNpIoIDGcsphtFs-Ds.ttRacAYGWHVlts..sGcDspuIptAltpA+tsps+PoLIts+TlIGaGussptGscssHGAPLGs--ltth+pthGac.ttsFtlPp-lYstapt+ht..GtptpppWpphFusYtptaPEhuAEhtRRhsGcLP	.................................................................................................................h.....ptlRh.s..hphl.t...pu..t...........u......G.......H................G..s......s..huh.A..sh..h...s.L.a..p....c...h......h.p...h.p...P.t.......p.s.........p......h..........s.R.D..R..a.lh.....S........t.GHu.u.hlYuhLa..L............p.............G...................h..................l............s.h.....-c.L.c.s.FR..........p......h.....t.......S....p........s....s......G..........H.......P.c...h....t.h................s...G..........l....-.h.o.TGsL.G.p.Ghss....AlGh..A...h...u...p...+...h...h...t...t................t...........................h.p...h.......s..p.......h..sY...s..hhGDGph.EG..uh..........E........A..........hs....hAup.p....L.s...pLlhhh.D.s.N..t........h...p......l........D..............G.....................s..........p.........h.............h........h.........s...........p..........c............h.........t............t.....+..........a....c.u.....h.......G..W....p.V.....l.p......s...............s....G..........p...D....h....p....t....l.........t....A....h.......p....t....A.......p.......t..................s.......+..............P.olIhs.+.T..h.h...G..h..G..............s........t........h.......t..........s..........p......t.....t......s.......H......t..........t.................h....s................p......t...h.......t..............h.h.......t........h.........................................................................................................................................................................................................................................................	0	827	1666	2288
+4688	PF01818	Translat_reg		Bacteriophage translational regulator	Bateman A	anon	PSI-BLAST 1reg	Domain	The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs [1].	25.00	25.00	73.20	73.00	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.63	0.71	-4.58	11	74	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	70	2	0	56	724	121.60	58	92.25	CHANGED	MlEIsLpcP-DFLKlRETLTRIGIANsK-KpLYQSCHILQKpG+YYIVHFKELLpLDGRpVclopEDhpRRNsIApLLcDWGLspIlssc...-hsspNpFRVISaKpKsEWpLhsKYpIGp	.MlElsLpcP..-D...FLKV+ETLTRIGl.AspK-.KpLYQSCHILpK......pGpYYIVHFKEL.htLDG+psslocEDh.RRNpIspLLpDWGLlcIlsspthhc.hssh..Nph+VIoaKpKsEWpLhsKYsIGp...	0	0	0	0
+4689	PF01997	Translin	DUF130;	Translin family	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	Members of this family include Translin Swiss:Q15631 that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen [1].	20.40	20.40	20.60	21.00	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.33	0.71	-4.72	74	629	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	351	42	428	614	144	190.20	24	78.99	CHANGED	cctREcllclsR-lsphS+cslht................lHptst..........tt.st.phlpcsppplpplp.phht...............shs.........apaptthssuhQEalEAhshhtal...........................pst....pLhohc-ls..h.............................................................ls.t-YLhGlhDlsGELhRhslssltpGshcp...................................shplhphhcclasthhhlsh...............th......tslR+KhDsh+pslcKlEpslashpl+st	...........................................................................................................phRE.clhchs+-lpttu+chlhh...................lpphpt............................tp.sp.chhppsppplpp.lp.phht................sts....................hapappthp.slQ-h......l.puhsahtal...........................c.sp....sL.l.ohc-lsp.l.h...............................................................h.ls.p-YLhGlhclsuEL.....h........Rhsls.slst.G-.hpp.........................................shplhp.hlpcl.hssaphlsh..................................................ptl.+.++hDsh+.s.......lcKl.EpssYslplRs.h.............................................................	1	140	221	335
+4690	PF02133	Transp_cyt_pur		Permease for cytosine/purines, uracil, thiamine, allantoin	Mian N, Bateman A	anon	IPR001248	Family	\N	21.10	21.10	21.10	21.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.43	0.70	-5.93	14	4605	2012-10-03 01:44:59	2003-04-07 12:59:11	10	14	1918	2	1514	3768	1528	398.50	19	86.59	CHANGED	PVsp.ccRshshhNhhshWhusshslssashuuss.lthGLsaapshlslhhusllsshhlsltuthGsphGlshslhSRuSFG.lhGulhPhlsts.lhAhsWaulpsalGupslhhhltplast....hhs...sh.ssssh.hlsFhlFhllphhhlahshpplp+hhshtuhlh.hsuhuhhhWshstspu....Gslhs..st.s.........hhsulhuslusauohlsshsDFTRaups.psshhsthlslshshslhhhhullssuuuhsh.hGsshWsshplltpa.ss.......hushlhslllshuplusNhusshlusGhshuslhP...hhlsh+puuhhsullulshssWsLhusssp...hhshLshhushLushuGllhADYahlR+uhhplsphat....psuhYha..chGhNacAhsAalsGhhhslsGh..........tsshsshthhsluYhVG	.....................................................ppR...p....h....t....h....h.s.hhs...hWh.u.sshsl.s.s.hshuu.hh...h.................h.................h...........G...Ls...........hh.pshlulllGshlh.s.hh.hsh...h.uh.hGsch.GlshhlhsR.h.s.F............G...h.................h.G.u...h.................l...ss.l..lt.s...lh.t.l.........u....W.............au..hps.hhu..u..........t.s...hthhl.s..p.h.hs.....................................hs..h.s.hh.l.s.....h..h..l..h.h..l.l............h...h.h...h...h..h.G...h.....p..s.......l...p...h.h...t...h.ht........s...........s.....h...l...h.l....h..h...h...s...h...h..h..h...h.h.sp.s.sh..........u....h....h.t.........t.s.....t...............hh...s..u..l....s....h..s..s...u..h....a................h.s....h....ss....hu...Da.oRa.......s..p.s........t..p.....s............s......h......h..........s........t....h...h....u....h...h...h..s...h....h...h.h....h.h.....h...u....h...h.....s...s...u...s..ssh...h.............s....t......s.......h....h......s.......s...h...................................h..s.....................uh.h..l..ss.l.l..l.h..h...h..s.l...s...s..s...s...s..s.....s.......h..........h....u..s..u...h...s.h....s..s...l...hs....................h........l....s..h..+...t.....t...s....h....l.....s..u..l.....l....u....h.....l....h....s....h..t..l..........h....s..s........sh................hh..a.........Lshlus.hlsPlh.....Glh.l.sD.Ya.l.l.+....+...t.p.h...p...hst.h....h.............................t..h...................s.h.......N........h...h...u..h...h...s......h..h.h.u.h..h.hs.h.h.....................................................................................................................................................	1	391	822	1249
+4691	PF04236	Transp_Tc5_C		Tc5 transposase C-terminal domain	Bateman A	anon	Pfam-B_2955 (release 6.5)	Domain	This family corresponds to a C-terminal cysteine rich region that probably binds to a metal ion and could be DNA binding (pers. obs. A Bateman)..	27.40	26.40	27.40	26.40	27.30	26.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.48	0.72	-3.75	14	75	2009-01-15 18:05:59	2003-04-07 12:59:11	10	11	10	0	72	54	0	58.60	37	15.42	CHANGED	WpKuGYh...spss.sFhTPupaC.Fs.cssssDChhsGCschuFI+Cu+CcphlCFcHFlV.phHhC	........Wa+uGYh...ss+Ps...tFcTPs-ah.Fs...csstssCsh..Csphuhl+CsaCcp.hCFscFh....H.C......	0	16	22	72
+4692	PF00872	Transposase_mut	Transpo_mutator; 	Transposase, Mutator family	Bateman A	anon	Pfam-B_376 (release 3.0)	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.15	0.70	-5.91	14	6867	2012-10-03 01:22:09	2003-04-07 12:59:11	13	34	1819	0	1273	6707	991	221.60	22	89.13	CHANGED	hspsp.hsthtth.sh...thsuts-hhcshhcshhpplhpsEhschlGstcaERsttRp.st.......RNGpps+slsTpsG.pl-lplP+sRsGsF.P.......sllp+hpRp-pulpuslhphYlpGlSTRclpchlptLhG.pt..lSpupVSplscplc-tltsapsRsLpcs.asalalDAhahKlR..sspVhupulhlAlGlssDGpR-lLGhtls..suEutphWpshLpsLpsRGLps.lpLlluDuatGLspAlstsasssshQRChlHhhRNlhstss+cpt.cpltstl+sIapAs-h-tsttth-thhsthss..+aPtlsshh-cuhpcllsFhsFPtsha+plhoTNslERLNcElRRRs+shslFPNtsohlRLlhslLt-h......cccWhtu	..............................................................................h...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................................h.....h.os.N.......Et.h.......h.+..t.............................................................h......................................................................................................................	2	397	800	978
+4693	PF00273	Serum_albumin	transport_prot; 	Serum albumin family	Finn RD	anon	Prosite	Domain	\N	25.50	25.50	25.80	25.50	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.31	0.71	-4.84	42	692	2012-10-01 21:15:37	2003-04-07 12:59:11	15	8	71	324	248	788	0	168.30	26	84.70	CHANGED	ppphspphpphG-cshpulsllthSQth.pssacElsKLlp-lsphtcpCsts-.....pChcshtshhhcclCpppshhs..utlscCCpcstsE.RspChhphcp-p.sth.shth.....s-scchCpsapcspctFhu+alaEhuRRHP.hhss.lLtlAppYpphlpcCCp..sps.ssCh	..................t.pp.Ct.hpphGccthpsh.hllt..hop+hPpsshp-lhplsp-lsphtp...cCC...p..s...st....hsChcs....ths.....lhsplCpppph.hs..splscCCscs.h.h.............p.Rp..Chhth.csDps...........shp....t............stsc-lCpt.pc.spp..thh.s.........p...a..........LaEhu+..++Pp.hsts.LhplsppapphlpcCCp..sps.tsCa..................................	0	11	18	55
+4694	PF01359	Transposase_1		Transposase (partial DDE domain)	Bateman A	anon	Pfam-B_394 (release 3.0)	Family	This family includes the mariner transposase [1].	22.90	22.90	23.00	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.44	0.72	-4.21	63	449	2012-10-03 01:22:09	2003-04-07 12:59:11	13	27	113	11	235	404	0	74.10	30	26.29	CHANGED	hY-..N.pRp+sWlpsGpssps.ssKsslas+KlMLsVWWDh.cGllaaELLtsGpTlsu-hYppQLp.cLppslpcKRPphhsR+	.............................a...s.pcp.tpWl...p.sp.s...p...ts.Kspl.atK.K...hhLslaWsh.p..Glla.a-l..LssGcTIsu-hYspQ.Lp.cl...tptlpphp.t.............................	0	51	123	182
+4695	PF01610	DDE_Tnp_ISL3	Transposase_12;	Transposase	Bateman A	anon	Pfam-B_1015 (release 4.1)	Family	Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204 (Swiss:Q50911) [1], IS1001 (Swiss:Q06126) [2], IS1096 (Swiss:Q50440) [3] and IS1165 Swiss:Q48788 [4].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.56	0.70	-4.80	128	7865	2012-10-03 01:22:09	2003-04-07 12:59:11	12	34	1808	0	1018	5504	425	158.50	24	62.84	CHANGED	lGlDEhphp+.tpp..hhshht.h..ct...........pplltlhtsRsppslppahp.h.s.p..pppplctVshDM.ssatsslpphhPp.Ap..llhD+FHllchhsc.ulspl...Rpp.hpph.......tt..............................lKps.+all..LK........p..cpLspp.pttp............ht...hh....pt.s...pltpAYtlKpphtpha...p.p........p....httupp...hhppWhpth.......tstls.........hpchscolppahptIlshFc..............hoNGhlEGlNs+IKsl+RpuhGa+shcphpt+l	...........................................................................................................................................................................................................................................................th.......hht...th.............................................................................h..ht....hhhh..............................t........ht....t...............................................h.....hh.............t.......h..hh.h....ht....hh.hh.....p.t...................................................h.t....h..tp.h..................h...................htphhtt.h....p...ht..l.h.shht......................ho.Nu.hEu.hNthl..+.hc..p.shGhts.t.hh..........................................................................................................................................	0	276	676	802
+4696	PF01710	HTH_Tnp_IS630	Transposase_14;	Transposase	Bashton M, Bateman A	anon	Pfam-B_1769 (release 4.1)	Domain	Transposase proteins are necessary for efficient DNA transposition. This family includes insertion sequences from Synechocystis PCC 6803 three of which are characterised as homologous to bacterial IS5- and IS4- and to several members of the IS630-Tc1-mariner superfamily [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.57	0.71	-4.44	9	1697	2012-10-04 14:01:12	2003-04-07 12:59:11	11	12	366	0	262	1502	90	102.50	39	76.09	CHANGED	MAYSlDLRpKVlsalEsGGuITEAS+lFpluRsTIYpWLp.+Echush+spsRpp...KlDp-cL+pclcsNPDhhLpEhA+cFGV..pPuolpYthK+MtlTRKKpshh.cpt..+.sphppshs	.........................................YShDhRp.KV.l.s.h.h.E.c.s.t.o.h.oE.AS....c....l.......F.......p.......l......S...R.sT.Ia....tW...Lc....hK.......c...c...T........G....-....h.....p.....p.......p....s.....+....t....pp.......tK.l.....D......h...c...c...L...K...s.a..l....p.....c...p......P.......D........s...hl...p......E......l......A......p......c......a......s......s......pss..o..lp.h..ALKt.hGhT.p.KKp..........................ph.......................................................................	0	52	103	234
+4697	PF01797	Y1_Tnp	Transposase_17;	Transposase IS200 like	Bashton M, Bateman A	anon	Pfam-B_1347 (release 4.2)	Family	Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases for IS200 from E. coli.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.40	0.71	-4.25	178	5614	2012-10-02 12:35:40	2003-04-07 12:59:11	11	33	2186	40	1185	4727	578	98.60	26	68.64	CHANGED	hhphpaHlV...assKYR+pl.lssp.ltpclccll.pplspphphcllp...hsstsDHVHlLlphsPph.ulScllptlKutSS+hlp..pcasphhpphhh......h..WspuYassosG..ss.shcslccYIcsQ	.......................................................................................h.....hahh...hh.sp..Rp..th..h.tp...h...t.........pthtp.hh.tp.h.s.p.....h.........t.....h.p.lht..........h.p...h.....s.DHlH..h.L.l.......p...........h..........s.........s.....p...........h.......s............lo......p.......h....h...th.lKu.t.o...u.h....h....lh............pp.....h...........p..h.....t.....h....+hh..................tth...W.s.p.u..Ya.sp...oss...t....s.thlt.p.YIpt..........................................................................	0	388	819	1034
+4698	PF01385	OrfB_IS605	Transposase_2;	Probable transposase	Bateman A	anon	Pfam-B_1210 (release 3.0) & Pfam-B_4602 (Release 7.5)	Family	This family includes IS891 [1], IS1136 [2] and IS1341 [3]. DUF1225, Pfam:PF06774, has now been merged into this family.	19.00	19.00	19.00	19.00	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.55	0.70	-4.96	39	7021	2009-01-15 18:05:59	2003-04-07 12:59:11	14	26	1439	0	1819	6621	252	194.50	20	55.24	CHANGED	ppYp.plsutssQpslccsspAacSFFshhcthcpt........sphP+Yppc....pt.........phhlhhppsphp....hcpsplplsh...............hplp.hcsphphchc.....ps+lhhhhpth....spahsplsh-.hpt......................spspssptsuIDlGlssLsslssspst.......hlhpu.+.ltut.phhs+phuclppp........hptpt........p+ssc+lp+LapKpspphcchlcphsppllpphhph..slpslslGthpthp	....................................................................................................................................th.s..shptsht.ph.....pu....a.pp.ahpth............................................thP..p....a+pc.......t.............................t.....h......p.t...t..t..hp................ppt.....t..l.hlsh............................................h.t.......h..p..h.....t...p.p.p.h..t....................thp.t..h...h.l.tpp..............spaal..s..l....hc...hp.....................................h...t.s....s.p.h....l...G.lD..l.....Gl..p..p..h.s..s..h...o..s..u.p..............................h..p...s....p...............h..p....p....h.....p...p...c..h....t....+..h..p..+..p.l..s....++......................................hptupp..............hp+tptc......l....t.+.....l...a.......p.......+ls....sh+p........Dhh....+..+l..oppl..sp.p..h.t..hh.....sl.EsLthtsh....pp............................................................................	1	529	1255	1605
+4699	PF02992	Transposase_21		Transposase family tnp2	Griffiths-Jones SR	anon	Pfam-B_1531 (release 6.4)	Family	\N	25.40	25.40	25.40	25.40	25.00	25.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.29	0.70	-5.26	49	1289	2009-09-13 07:43:22	2003-04-07 12:59:11	9	104	66	0	750	1419	1	149.60	32	20.18	CHANGED	chhRWHtEp+p..pDGh.hRHPuDupsW+phDcpaP.-FAs-sRNlRluLuoDGhNPFu..uspaShWPVllhsYNLPPhhCMKpp.hhLolLIsGPppPGssIDVaLpPLl--LppLWp.pGVcsaDs.ppcpFsLRAhLlaTIsDaPAhu.LSGhss+Gph.ACshChcpTtuhhLcpupKhsahs.HRRFLPhsH.aRppcptFcss..hEppssPp.h...oGcclhpplcslp	................................................p.............................................................................................................................................................hh.G....P.ppP.s...p....s.....l......s..s..aLpP......llc-lt.L.ap....tGh............h..........h........c.t..t.p......p....h...l.+shlh.hshsDhPAht..t.l.u.G..........p.u.h..h.....uC..h.C.p.h..h.......h.....tt......+.........a.t.......h........................................................................................................................	0	205	337	361
+4700	PF02994	Transposase_22		L1 transposable element	Griffiths-Jones SR	anon	Pfam-B_2299 (release 6.4)	Family	\N	25.00	25.00	25.00	25.00	24.10	24.90	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.27	0.70	-5.96	3	1528	2009-01-15 18:05:59	2003-04-07 12:59:11	9	29	45	16	1329	351	40	221.10	32	80.72	CHANGED	+GKRRNhoNRNQDapuSSEPsoPTSuSPusPNThENpDLDpKuYLhMMlEGlKKDspsSLREplEspuKElQpsLKEhcEsIsKQVEshpEcoEKohKElMEl.......................pKpl+ELKcEl-oIKKpp.EsTL-IEs.tK+pGslDhShoNRIQEMEERISGAEDSIEpIsoTlK-NsKpKKlLsQNIQEIQDolRRPNLRIIGV-ESEDpQLKGPsNIFsKIIEENFPNLK+EhslsIQEAYRTPNRLDQKRNTSRHIIVRToNApNKERILKAVREKGQVTYKGKPIRITPDFSPETMKARRuWTDVIQTLREHKhQPRLLYPAKLSIIIEGETKlFHDKTKFpcYLSTNPALQRIIKE..KsQ+KNuspsLEcsR+	............................................................................................t..........................................................................................................................................................................................................................................................................................................................................................................................................t.....l.......s...s.Rh.pph....E...-.+.IS.p.lE.......-.t.................c.h.......h....p.......s...p...........c...p.......c..............t......c..............l..............+...p..............p.......p.p....lc...-.......Lpsp.h.......+..R...s...N.lRIIG...lPE..G.pc.....p..t...c.s..s....p.sl.h..pcIh.....t..E..N..hP...s...L....h.c...ch.c...lplp.c..A..p..R...s..s.sh.h..s.s...c...c...s...s.....P...R..p.Ill..K........hh....+.hpsKE+.....IL+s...ARp.+.....p.ls.....a.+..G......ps...Ip.l......sD..hSs.-s.hptR.R.ca.pslh+.L+c+.sl.p.p...l...hYPu....+lp.hphp..G...c.hp.....F.s.t...h...........................................................................................	0	10	330	417
+4701	PF03017	Transposase_23		TNP1/EN/SPM transposase	Griffiths-Jones SR	anon	Pfam-B_1491 (release 6.4)	Family	\N	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.23	0.72	-4.46	33	134	2009-01-15 18:05:59	2003-04-07 12:59:11	9	22	10	0	57	124	0	67.50	30	18.45	CHANGED	ppss..KChllDWssscc.lVuEGchpSs-P...pphV.splPLGPsAspVhVcslh.s-AhlWRPssplhhlt-ulGs	......................hhsh.t.pp.hVAcuplhStsP...pphV.sshsLG.phscVlVcsV...h.p......p-AhL.RPhsplphhtDAl................	0	0	41	49
+4702	PF03004	Transposase_24		Plant transposase (Ptta/En/Spm family)	Bateman A	anon	Pfam-B_1902 (release 6.4)	Family	Transposase proteins are necessary for efficient DNA transposition. This family includes various plant transposases from the Ptta and En/Spm families.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.80	0.71	-4.30	40	501	2009-01-15 18:05:59	2003-04-07 12:59:11	9	46	31	0	204	486	0	114.70	17	21.72	CHANGED	sschWpshl.....paWpoccuccpScpsppsR......uhuh....hhHpuGppSatpltcchcpch.......scpsshh-lahcTHp.+sDGo......alcp+ucplhcphppplpcp.sphsstsst.s..................phscla...........................hpssutcc+.GRha..GlGuhtpsh	..............................................t..t.Wt.hh.....th.Wt.s...c.hpthStpsptsR.......ttht.......hhHpsGo.....coas......thtcp..hptc.....................sp.ss.hh.......clahps+..p..p..psGp...........stt.s.pp..h..hp...t...........hpp.htp.....t.............................................................................................................................t....................................................................................................	0	4	77	124
+4703	PF03050	DDE_Tnp_IS66	Transposase_25;	Transposase IS66 family 	Bateman A	anon	Pfam-B_2526 (release 6.4)	Family	Transposase proteins are necessary for efficient DNA transposition. This family includes IS66 from Agrobacterium tumefaciens [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.98	0.70	-5.18	126	5890	2012-10-03 01:22:09	2003-04-07 12:59:11	9	35	1314	0	841	6700	1022	192.80	29	59.76	CHANGED	+uhsusuLlApllssKasppLPLYRQpphhsct.Gl.plsRuTlusWhtpsuph.LpP.lhstlpptlh.psshlasDETslplLt......tp...sc.sp.pualWshssst................hlhapass...sRu.upts.pph.....Lts....ap......hLpsDuYuuYsp.lh...........slpc..ssChAHsRR+Fh-shpt..................shuspuLpt.IspLYt.......lEpch.......p................s.....-.......pRtthRpppupPllsphcpWhp.....tph........tplsspotlucAlpYhl...sphssLhpalcDGcl.plDNNhuERulRshslGRKNa.LFusotpGuct	..........................................................................h...h.....s....p...t.htt....G...h....lstt..hst.h.h..........ht.....ht...h.....t.....h....t....lh...........h..l..tsD-ssh.....................t.tp..sh.h.Whhhtst.....................hhha...h..t..t+t..t............h.........h...............ht...u........hl...sDt....ht....sat...h.....................h........hChs...H.h.....p..Rt..h...ph....................................ht.hlt.........htt....ha.t.................................hc.t...th.t.....................................p...................ttht.R.p...........lh.t.t.h..t.hh...................................................ph....t.s...h.tp.u.h...t.Yhh....pph.t.h...ahps..u.h..hs...NNhsEpslR.hsls...++s.hh.ts..us..........................................................................................................................................................................	0	197	489	640
+4704	PF03400	DDE_Tnp_IS1	Transposase_27;	IS1 transposase	Mifsud W	anon	Pfam-B_2448 (release 6.6)	Family	Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.65	0.71	-4.04	2	3369	2012-10-03 01:22:09	2003-04-07 12:59:11	8	11	576	0	195	2345	250	104.30	60	82.31	CHANGED	hllC.EhDEQWuaVGuKuRQ+WLaYAYsphptsVlAasFG.RT.tThtcLhuLLoPFslshhhoDsWs.Ytpcl.tchHlhtKhaTQRIERpNLsLRp+ltRLuRKolsFS+SVElH-KVIGpalph+ha.	.............................................................h..DEpWuaV....G.uK....u....R..Q+W.LaYAY.c........php.c.sV.l..AaVF.GcRT........hsTlt.........+L.h.u.....L..L....o.s..F.....c..V.s...l..aMTDGW.PLYESR..L........K.GK..L..H..V..I...S...K.R..Y..T..Q..R...IE.RHNLNLR......QH...LARL...u...R.KoLSFSKSVEL...HDK.VIG.aalph+aa..........................................	0	49	122	175
+4705	PF04195	Transposase_28		Putative gypsy type transposon	Bateman A	anon	Pfam-B_1755 (release 7.3)	Family	This family of plant genes are thought to be related to gypsy type transposons.	20.10	20.10	20.20	20.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.09	0.71	-4.99	2	725	2009-01-15 18:05:59	2003-04-07 12:59:11	7	21	14	0	419	710	1	151.90	37	20.83	CHANGED	MActptsh-uphhPsshh.pphpthls+chhPtpthht.hsAhGEuhPTPch..csVhF.pFhhsGhs.Ph.pFFhsILEFYslphtHLsPNulhhlA.FhHhCEhFlGlRPphhLFphhFhlp....hS.PhVVGGshFQ.RGpl.p+Yhshsh+pp.csW+usWFYs..s-.A...LPp.s.	......................................................................tph....p.hls+thh...P..tp..t..hh..t.h.h...h.G.E..u.h.PsPph....csV.hF.sFhh..uGhh.....PhSpFFh..s.lLpFYslphtHLsPNulhplAIFsHlCEhFlG.l...c.PphpLFRhhF..hlps.........hs..s.....s.........V.........s.........G.....u.......sh.Fp.R.s.sl....p..+...Y.h.sh.s...h.+pp..c...s.W+upWFYh.......sp..s........................................................	1	0	19	24
+4706	PF04693	DDE_Tnp_2	Transposase_29;	Archaeal putative transposase ISC1217	Mifsud W	anon	Pfam-B_5730 (release 7.5)	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.09	0.70	-5.43	3	202	2012-10-03 01:22:09	2003-04-07 12:59:11	7	3	27	0	42	452	37	154.30	27	83.72	CHANGED	MsKEL..sRpEYYKALccAlsplhhuMTGlRKDVAsRLlLGuVlGGsAT..EIAQss-MDYETVLKNLDKLANs..cLIElVKKlVtDHPVlLIIDDTHDHKLYARAhPV.SRNGsQhFYCRsHKRFEPAIQLLlIAlKDLssNcoYlIsIIPYIPRKVtE.LKcRGEcuEFKTKI-hhLEhLsoLhscaNVsslVFDSWYVNSKTLpGNTVGELKSNuRVVE...........G-RHVPVuEFPpGEYLVEYL..GTPIKLLVIDsYKchGRRYFFSTDLNDTsEDIITTWENRWDIEVLIRELKALGLEcSSFLTWlRNpGFlsLKALSLLlVpsFKYSLGL+LG	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	23	23	41
+4707	PF04740	LXG		LXG domain of WXG superfamily	Zhang D, Mifsud W, Aravind L	anon	Pfam-B_3568 (release 7.5)	Family	This domain is present is the N-terminal region of a group of polymorphic toxin proteins in bacteria. It is predicted  to use Type VII secretion pathway to mediate export of bacterial toxins [1].	22.30	22.30	22.40	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.12	0.71	-4.53	35	970	2012-10-01 21:44:22	2003-04-07 12:59:11	7	41	392	0	96	785	2	186.40	20	39.12	CHANGED	KplDspplhstl-pptpphcphppplpslcpulpslssLcs..LpG+uuculKsaapshahPlhpthhphl-phpphL.pplpstlpsh-stssuhI-psFLcpEL..ppuls+scphhpphpppl..sshhsslsDllpls.hsppshppplppApcchpcsl-+LtshDpptsshhspscsthptlpphlppLpshh.ssut........pssuYp	....................................th.t..pph.t..pphppphpslp...p.ulpp...h...hssss...L.pGcuhsusKsaappshhPlhps...hhphh-thppth...tphl.p.p.apupV.-.s...s..p.shlc.p.shLc....-l.........pplsp..pp.h..pshp...p.p.h........pp....h..h....s.s...t..p................h..s......p...ph....hp.......ph....tptp...+.clpcpLc...+Ltp...F.s...p.pp.s.p...ap.ph.p......ph.p.lppslpplpshh....................s......................................................	0	29	53	79
+4708	PF04754	Transposase_31		Putative transposase, YhgA-like	Mifsud W	anon	Pfam-B_3820 (release 7.5)	Family	This family of putative transposases includes the YhgA sequence from Escherichia coli (Swiss:P31667) and several prokaryotic homologues.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.06	0.71	-4.96	54	3243	2012-10-11 20:44:43	2003-04-07 12:59:11	7	7	798	0	393	1853	67	186.50	44	64.84	CHANGED	sPHDulFKphhspspsA+-FLchaLPspltplsDLsoLclEssSFl--sL+ppaSDlLaSlcspp............t.cG.....YlYlLlEHQSpsDphMAaRLh+Yslshhp.......+H.hct..........scpp.LPlVlPllFYHGpps.ashshsah-hFs.....sstlAcplhstsa..LlDloshsD-EIhp++p....huhLpLl.KHI+.pR.Dlhchlcplsplltphhpscpplp	.............................................................................pPHDAlFKpFLtp.s.-.sARDFlp.....lHL..P..t...l..+..plCD.......L....pT....L....+..L.Es.s...S..F.l.........-....c..s...L.....+.....t.....h.a.SDlL.aS...lcTpp.............G...sG.....Yl..Y.s..l..I.EHQSps-.phMAF..R.........hM.....R.....YuhAA..MQ..............+H..L.-t...............................sa.c.p......LPLVlP....l......LFYHGppo..PY..P....a.S.h..s..W...h.DtFs........sPt.lA+pl.Y.s..p..sFP...LVDlT.lh..PD-..E..Ih..pHR+.........hAlLE.L.l..Q.K..H...IR.pR..DLht.ll.-pl.ssLLsps.ssspQ.p..................................................................................................................................	1	151	264	314
+4709	PF04986	Y2_Tnp	Transposase_32;	Putative transposase	Moxon SJ	anon	Pfam-B_5271 (release 7.6)	Family	Transposases are needed for efficient transposition of the insertion sequence or transposon DNA. This family includes transposases IS1294 and IS801. This is a rolling-circle transposase.	20.70	20.70	20.70	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.12	0.71	-4.54	65	1246	2012-10-02 12:35:40	2003-04-07 12:59:11	8	16	499	0	183	1121	344	156.80	27	48.81	CHANGED	GhhuVLHTaGps.LsaHPHlHhllsuGGlstss.....pWtp....sp.t.ahhss+sLuphaRsphlptLppth.t..h........h.t.tthsthltphhpc................................................pWsVhsp.shs..pscssLpYLuRYhpRssIospRlhphs......sspVsF+a+Dhc...............sscpcphsLsstEFlcRhlhHVL.PcGF++lRaYGhLu.....ttcppp	...................................................................................................................Ghhshlppa.Gpt.hphpsHhHh.h.sGshsptt.........................hhh.hch....tp..hhphh.phl.pt.h.th.................htpttt.p.hh.pthtc..................................................tasl.sthhht....ssp....psh....tYLuRYlp+sslutpRLtt.hs.......tspltaphps.p...............ppppphhhhss.-FltRhhhHls...thp.hhRaaGhhu.......pt........................................................................	0	73	119	151
+4710	PF01498	HTH_Tnp_Tc3_2	Transposase_5;	Transposase	Bashton M, Bateman A	anon	Pfam-B_462 (release 4.0)	Family	Transposase proteins are necessary for efficient DNA transposition.  This family includes the amino-terminal region of Tc1, Tc1A, Tc1B and Tc2B transposases of C.elegans.  The region encompasses the specific DNA binding and second DNA recognition domains as well as an amino-terminal region of the catalytic domain of Tc3 as described in [1]. Tc3 is a member of the Tc1/mariner family of transposable elements.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.15	0.72	-3.92	26	1241	2012-10-04 14:01:12	2003-04-07 12:59:11	13	82	129	7	1065	1248	10	65.70	24	22.63	CHANGED	cRpIlphlccsPp...hohpcLtpphtp..GhslSppTlp+pL+ptGhpu.pps+++Ph.Lotcpt+sRLpFAppHls	...............................................................ostclttpl...............s.h.slStpTlp+hL.+p.t....G.h..tu..p...ht.h+.K.P........h..Lo......t....pppct.RLtaAptH.............................	0	570	817	1048
+4711	PF01527	HTH_Tnp_1	Transposase_8;	Transposase	Bashton M, Bateman A	anon	Pfam-B_527 (release 4.0)	Family	Transposase proteins are necessary for efficient DNA transposition.  This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.29	0.72	-4.02	45	12930	2012-10-04 14:01:12	2003-04-07 12:59:11	15	69	2688	2	2404	10672	1730	75.20	20	64.00	CHANGED	hpp.pRaocEhKtplVcps...csGtslsclu+chGl.ssssLapW++ph..........suhtssssp....................h.hshpp-spcLc+hhsc	................................tpppa.otE...h...K.h.......p...h...l.p................s.........h........c........s.......s........h........s........l..s.......p.........lA..c....c....h.....Gl..s.s.s.....s.l.hp.W.h+.php................ts.t.s.s..tp...........................................h.t..ptc.tpLpt....t..................................................................................................	0	628	1441	1931
+4712	PF03221	HTH_Tnp_Tc5	Transposase_Tc5;	Tc5 transposase DNA-binding domain	Mifsud W	anon	Pfam-B_2955 (release 6.5)	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.26	0.72	-4.16	194	2088	2012-10-04 14:01:12	2003-04-07 12:59:11	11	91	246	2	1635	1984	4	63.10	21	13.60	CHANGED	hsph-csLhpWlpph...pppshslosphlpppApp.lh................ttsshpsSps.....Wlp+FhpRa..slptpp	...................................t.EctLhpWlhph......pppG....hs.......s.otphlpppApp.lh...........................tts.shps.ups.......Wlp+..FhpRa...tlt...h.......................	0	469	953	1437
+4713	PF02281	Dimer_Tnp_Tn5	Transposase_Tn5;	Transposase Tn5 dimerisation domain	Mian N, Bateman A	anon	Pfam-B_5683 (release 5.2)	Domain	Transposons are mobile DNA sequences capable of replication and insertion into the chromosome. Typically transposons code for  the transposase enzyme, which catalyses insertion, found between terminal inverted repeats. Tn5 has a unique method of self- regulation in which a truncated version of the transposase enzyme acts as an inhibitor [1]. The catalytic domain of the Tn5 transposon is found in Pfam:PF01609.  This domain mediates dimerisation in the known structure.	21.40	21.40	21.40	21.40	20.70	21.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.43	0.72	-3.93	2	403	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	154	6	49	283	17	97.40	52	31.63	CHANGED	EuhTlP.hLRtpGLlcEActVEuQSs-TVLp.DEhplLhhhsKs+tc+tptAsSLpWAY.uIA+LGGFhDoKRTGIASWsAlWEGWpsLQS+lsGahsAK-hhApG.pl	.............hhlssplhs.........R.hGl.pE.....sps-SCEKILTPoEWKLL.W.l+lcGK.....LP..sQhP.TLK.........WAsLpLAKLGtWHDS.KRTGcPGWsVhWDGWFRLQDMlEGYhlhKSL.......Dp-.....................	0	11	26	31
+4714	PF00576	Transthyretin		HIUase/Transthyretin family	Bateman A, Percudani R	anon	Bateman A	Domain	This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain.  However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to OHCU [2,3].  HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage [4]. HIUases are distinguished in the alignment from the conserved C-terminal YRGS sequence.	25.30	25.30	25.30	25.80	24.70	25.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.54	0.71	-4.18	26	1803	2012-10-02 19:08:27	2003-04-07 12:59:11	16	7	1506	439	545	1303	706	109.50	40	82.21	CHANGED	ssLoTHVLDsupGpPAuulplcL..........a+hs...ssshp.lsostTspDGRh..tsLlsspphtsGhYcLpFcsucYaputGh................ssFh-hlsltFsls-ss..pHYHVPLLLSPauYSTYRG	.............................................s..LosHlLDpspGpPA...........ssVpVpL...............................ch...s........sssh....p..l.s.s...uhTspDGRl............ts..........l.........h.................s...........t..............p.................s..........h..............s.....sG....................t..................Y..+lhF.csucYF...cpp.sh...................psFas..pls......lpFpls...css.......pHYHVPLL.LSP.auYSTYRG..................	0	132	273	418
+4715	PF03896	TRAP_alpha	TRAP-alpha; 	Translocon-associated protein (TRAP), alpha subunit	Finn RD	anon	DOMO:DM07004;	Family	The alpha-subunit of the TRAP complex (TRAP alpha) is a single-spanning membrane protein of the endoplasmic reticulum (ER) which is found in proximity of nascent polypeptide chains translocating across the membrane [1].	23.10	23.10	23.10	23.40	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.92	0.70	-5.41	11	349	2009-09-11 14:06:22	2003-04-07 12:59:11	11	8	203	0	190	299	3	225.90	31	89.23	CHANGED	M+.h.plLLLhLLuFPusLl.hutspu.hssA..p-...--Es........-D.lsp---DpA.VE-Dp..t.oEt-E---.....tplpuSPcADTTILFVKs........c-FPAsplVKFLVGFTNKGs.cDFlVESlEASFRYPQDapaYIQNFTA..........LPhNslVpPpcpATF-YSFlPuEsh...............uGRPFGLVIsLNY+DusGNsFQ-AVFNQTVsIsEp--GLDGEThFhYlFLuGLulLllluhaQhLpSppR+Rs....tthVEhGTuups-VDhsWIPpETLspl.....sK....uSP+............pSPRpRptKRuAGsD	....................................................................................................................................................................................................................................................................................t..............tsssts.cshhhFsps...........p.hsusp.schLl.uhpNc..G...p....p.shhVpslp....u...Sh....+....hP.t...D.......a.......phhlQNaTA..........h..h.s.t...V.s..tppuThpYsFhs.sc.h...............t..spsasLsl.sls.Yp.Dh..s.....G..p.h.ap.sss.aNpTVsllE.t.p.su.l.DsEo...lFhY..hh.L.s.u.l..s.l.h.s......lh..hht.........p......h.....h.t..t....h...p+p+.......................h.plE.....h..........G.....T...s......s.....t..p.s........h...D..pWl...Ptcp..l.p.....................................................................................................................................	0	55	83	145
+4716	PF04051	TRAPP	TRAPP_Bet3; 	Transport protein particle (TRAPP) component	Wood V, Finn RD, Mistry J	anon	Pfam-B_9946 (release 7.3) & Pfam-B_6495 (release 8.0)	Family	TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits.  This family contains many TRAPP family proteins.  The Bet3 subunit is one of the better characterised TRAPP proteins and has a dimeric structure [2] with hydrophobic channels.  The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues.  Bet3 is proposed to localise TRAPP to the Golgi [2].	20.70	20.70	20.80	20.70	18.80	20.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.99	0.71	-4.69	84	1130	2009-01-15 18:05:59	2003-04-07 12:59:11	11	22	333	34	772	1043	17	154.70	25	76.72	CHANGED	hFslhauplVs.hhc.............shp-lp.........................................................................ppLcphGaplG......hRLlE..................................chhh+..............................................................tt.tRppchhcshchlspsha+hhauppsss...........................lppspt.....................tpah.lh-p.s.l...............................spal.p.s.....ttht.pL.....................passhhsGll+GuLpshthsspVshpps.h...........h.stsshpI+hph.p	...............................................................................................................................hshhasplVs..hhp......t........sht-lp...................................................................................................ppL-ph.............GaplG......h+LlEphht+..................................................................................................p...tRhpchh-hhchIspshW.ph.has+p..s...c..s.................................lppsp....p...........................spah..lh-pp..l....................................................spal.phs..............p..t.t..tl........................................asshhsGll+GuLpt...l..sht.s.......p.Vshp.s.h..............s..ssh.lcht..h.....................................	0	266	420	622
+4717	PF04956	TrbC		TrbC/VIRB2 family	Moxon SJ, Bateman A	anon	Pfam-B_5261 (release 7.6) & Pfam-B_14627 (release 10.0)	Family	Conjugal transfer protein, TrbC has been identified as a subunit of the pilus precursor in bacteria. The protein undergoes three processing steps before gaining its mature cyclic structure[1]. This family also contains several VIRB2 type IV secretion proteins. The virB2 gene encodes a putative type IV secretion system and is known to be a pathogenicity factor in Bartonella species [2].	28.40	28.40	28.40	28.40	28.30	28.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.14	0.72	-3.99	114	1258	2009-09-11 06:06:03	2003-04-07 12:59:11	8	2	765	0	305	1048	45	96.80	19	86.80	CHANGED	Mp.................hhthhhhhhhshhhhhhhspsAhApss..........sshpsslpslhshlpG.luhsluslsllssGhthhhGphs....hpphhhlllGlslhhuAsplsshl	..........................hhh................hhhh.hhh.hh.h.h.hs..ss.AhApsss................tshpsslpslhs.lpG.luhsluslsllssGh.thhauptp........hppll.h.lllGhs....lh.h.uAsplssh................	0	47	166	228
+4719	PF03743	TrbI		Bacterial conjugation TrbI-like protein 	Finn RD	anon	Pfam-B_776 (release 7.0)	Family	Although not essential for conjugation, the TrbI protein greatly increase the conjugational efficiency [1].	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.83	0.71	-4.80	149	1918	2009-01-15 18:05:59	2003-04-07 12:59:11	9	40	1082	20	412	1681	119	183.10	23	39.41	CHANGED	hhl.tGohIsusLhTulsSsh........PG.l.hspVopsla.ossG....ptlLlspGopllGpY.pus...ls.GpsRlhlhWsRllhP.s.....Gts.lsl...stsusDth.GtuGlpGp.VssHahphauuAhlhollus....ssphh.............sssssssssssh...............hhpsssp.shsphupphlcpshslt.PTlplptGph.lslhVs+Dlsh	....................................................................................................................hlstGohIsssLh.oulsosh.................sG...l.hsplspsla..sssG....phlL.l...sp...Go....plhGph...pus.....ls.u...p.s..R..lhlhapch.l.hs..s.........Ghs..lsl...............stsuss.........h..G...tuG..........lpGp.V....s.s...+h.h.phh...usAh.hhuhlss.hsphh..........................................t...tt..psstsspsth.....................................................................................thtpusup..uhsphup.p...hlcp..sh...sl...Ps.lhlptGpt.lslhlscDl.h.......................................	2	81	230	319
+4720	PF04610	TrbL		TrbL/VirB6 plasmid conjugal transfer protein	Mifsud W, Bateman A	anon	Pfam-B_5275 (release 7.5) & COG3704	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.67	0.70	-4.65	129	1847	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	1036	0	437	1663	116	208.00	14	43.80	CHANGED	lslhlhlhGhhhh...hst.hptsh.tchltchltlul.hshlhts.....hs...sasshlhsshss.hstth...uu.........sstsssshtthspl..h.stuhshsptl.........hppssshh............hhhhhhth...lhhlsshlhhhls....uh.lhlshlthtllhhhGPlhlshhla.shTpphhppWlsplluhulhllllsllhul....shshhs.shhssh...................ssspsslppshshllhuls...hhhlhhtsPslA....uul	.....................................................................................................................................hl.hhh.h.sh.hh.....ht.....t.....sh....phh.ht.....hhh.hsh...hhhhh.s.......hs.........h....phl.h....p.h...t.htt.h...........st..............................ts.h...sth.........h...thsht..h..ht.h..................................................hpphsth.........................hhhhh.hhh.....lhh..l.sh.h....l.hhhhh........shhh.llshl........thhlhh.hh...u.Plhlsh..hh.a.shT.+p.h..hp..s.alp..tllu..h...sl...p...h.hllslllu.l.........hh.shhs..phhsth........................................tts.h....tt....h..h.....hh...hhslh.....hhhlhh.h.s.hht....................................................................................	1	96	236	316
+4721	PF03461	TRCF		TRCF domain	Dlakic M	anon	Dlakic M	Domain	\N	25.00	25.00	26.00	25.20	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.01	0.72	-4.05	117	4305	2009-09-10 17:08:24	2003-04-07 12:59:11	10	10	4219	3	926	3507	1246	100.20	30	8.89	CHANGED	cL....slsAhlP-sYls-.p......pRlplY++luss....pspc-lpclppELhDRFGshPpplpsLlplscl+hhApphslpplptpppp.l....hlpa.sppsshshpthhhhhp	.......pLplsAhlP--YI.s.D.p......pRlphYKRluss.............csp..p....-lc-lpsELlDRFG.......hP.....c....sppLLplspl+hhApphGlpc.l....c.....tpsps...l.....tlpF..sppsphp.........hh..............................	0	316	613	786
+4722	PF03546	Treacle	treacle; 	Treacher Collins syndrome protein Treacle	Griffiths-Jones SR	anon	PRINTS	Family	\N	21.10	21.10	21.70	21.50	19.50	20.60	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.24	0.70	-5.71	4	216	2009-09-11 10:35:01	2003-04-07 12:59:11	9	8	25	0	59	246	0	175.30	26	51.50	CHANGED	sPAPPGKsGPuAsQApstKPEEDS-SSSE.-SDSE-EsPAshsssQsKPSGKsPQVKuASssupps..spKGsPPVsPGKAGPsAsQA......tc.pspSSpcppssptEsPsAh..TpS.spsKP.tpsSQVRssSsss.Gs.........PtKstssA..sQsGKp.EDS-SSSEEESDS-s.....suuPAQAKSSGKl.Qh+sASGPsKtPPQKAGPsATQVKs-+uc-DSESSEEpSDSE-..EAPsAhosAQAKsAlKhsQhKASP+KGTPhossuA+ssPVpVGTsAPpKAuAVoSPssuSSPAlA+GTQ+PsEDSSSSEESESEEE.TAPAsstGQuKSlGKGLpVKAASsssKts.GQGTAPs.PGKsGPuss.VKAEsQED.SESSEE-SsS...EEAAAsPAQVKTuVKpPQuKANsusTRsssAKushSAPGKsVsAssQhK.tSPAKsKPPsRs.QsSsVSsRGQsSVPAVGKAsAsAAQAQsGPVtsspEDSE.SSEEESDSEt..EsPsQsKPSGKTPQVRsASAPuKt	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	6	6	11
+4723	PF00088	Trefoil	trefoil; 	Trefoil (P-type) domain	Sonnhammer ELL	anon	Swissprot_feature_table	Domain	\N	21.00	21.00	21.10	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.01	0.72	-4.32	86	900	2009-01-15 18:05:59	2003-04-07 12:59:11	13	54	128	38	475	805	8	43.30	33	8.06	CHANGED	pCs.l.......ssppRlsCGhss...IopspCp.p+GCCacs...........p..........sssaCFas	......................C...h...ssppRhsCusss......lo...p..ppCp..s........+G......CCass.....................t.................ssPhCaas.............	0	154	186	297
+4724	PF01204	Trehalase		Trehalase	Finn RD, Bateman A, Wood V, Studholme DJ, Moxon SJ	anon	Prosite	Family	Trehalase (EC:3.2.1.28) is known to recycle trehalose to glucose. Trehalose is a physiological hallmark of heat-shock response in yeast and protects of proteins and membranes against a variety of stresses. This family is found in conjunction with Pfam:PF07492 in fungi.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.72	0.70	-5.86	20	2673	2012-10-03 02:33:51	2003-04-07 12:59:11	13	12	1263	20	654	2119	179	396.50	30	72.24	CHANGED	+hasDpKpFlDhshhs-..ssplhpthpsph.cs.st..sspsLppalc-sFpts.t.h............th.sPtstp-p.c.ah.h..pcssLRh.sppLsphWss..LsRplptpstths.thollshPp.........PaVVPGGRFpElYYWDSYahhLGLLtSsph-............hu+uMl-NFhahIc+YG+I.NGsRoYYLsRSQPPhLohMlhthhc+h..........ss-thh+chLsslccEasaWhs.......ss+hssVsshu..sapLstYhsss-TPRsESht.DhthAp+hs......-tscs.hYp-L+uuAtSGaDaSoRWlc-..Gps.s.hsslpTssllPVDLNulLa+hEpsIA.....hFssthsp.............hpsushacppAcpR+puI-paLWs--sGhahDYDhppp............cpsshhoAoshaPLWsshusscp....st.hsspslsphppsuhLp...suGlusoslc...oucQWDaPNGWAPhQhlshpGLp+YG....cplAccLAhRWLtpsppuascp....GtllEKYDVsp.......suchG..GGGGEYssQ-GFGWoNGVhlhhLchas	.................................................................................................................................................................................................................................h.......................................................l..hht..h...................................................................t.t....hp.....l..........h.....hh+..........................t.......................................p....h....st....................................sall.P....G....G..R..F.pE........h.Y....h...WDoYh.....hh................GLh.s.......t...h...p............hh..tshhtNhh..l..pthGh...l......Nu....sR.YY.....tRSQPPhh..uhMV..hhpt........................s.t.hh....p....p....hh...s....t.l....tt....a.s.a...Wht.................................s.t.....tp.h.s....t..h..................t..........h......Ls.p......Yhs...s..........-.......ss.p.s..-..S..h..h.sh..tsAt.p.s.........................ps.sthatp.l...c..s.s....t.ts..u......aD....h....o......S.R..W......h...tp.....s.............................................h...s...o.....l...............ps..........s......pl...l.......s.........l...D..L..N.....uh.hap.....cphlA.............phsthh..Gc..............................................tpps.ttacphApthp.ps.lp...phhWspp.pGh.ah.......D.achppc.....................................p.....p..p...h..h.s...s....s...u....h.hP..L.as.sh....Aspp..p......................s..p...h...h...s.p...h..t..p...t...p..h.lt.............PuGls.so...php........s.sp.Q.....W..D....t...Ps....u.....W....s.....P.h.pa..hu.....lpGh.p.p.YG...............................pphA.........c.l....utp....alpp........spp..s...a..................t................p..............p..................t..............t.lh.................E..KYs.st.....................................ss..t.....ss.hch.......p.....p...GF.GWoNushh.hlt...s......................................................................................................	0	245	385	556
+4725	PF02358	Trehalose_PPase		Trehalose-phosphatase	Bashton M, Bateman A	anon	Pfam-B_762 (release 5.2)	Family	This family consist of trehalose-phosphatases EC:3.1.3.12 these enzyme catalyse the de-phosphorylation of trehalose-6-phosphate to trehalose and orthophosphate.  The aligned region is present in  trehalose-phosphatases and comprises the entire length of the protein it is also found in the C-terminus of trehalose-6-phosphate synthase  EC:2.4.1.15 adjacent to the trehalose-6-phosphate synthase domain - Pfam:PF00982.  It would appear that the two equivalent genes in the  E. coli otsBA operon [2] otsA the trehalose-6-phosphate synthase and otsB trehalose-phosphatase (this family) have undergone gene fusion in most eukaryotes e.g. Swiss:P31688 and Swiss:P93653. Trehalose is a common disaccharide of bacteria, fungi and invertebrates that appears to play a major role in desiccation tolerance [1].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.31	0.70	-5.45	24	2499	2012-10-03 04:19:28	2003-04-07 12:59:11	11	26	1614	1	1046	2316	209	215.20	27	42.78	CHANGED	hhDaDGTLsslspp.s.sshssschhssLppLuucss.hlhllSGRshp....phhsps.slsluupHGh.lRhssuppaps...................s.stshshhcplttlhpphscphsGuhlEpKcsulshHYRpAssc....pspphhpplcsshpsp.slclppG+pllElRPshss.KGtslctllpphs.t..............s..sphslslGDDhT.DEDhFcslppt.......tshshclhsss..stpsopAthhlpsss	......................................................................................................................................................hhDaDGTL........s......sls....sp...P......p.t.....s..h.s.s.s...p..hhpsLpp.L.........us.ps...ss..t...lullSGRshsp........l........c........t..h.....s...........t........h..............p......l....s....lA.GpHG.h-h....+..t.....s........s.....u.....p.....p..hhs.......................................................................................................t.h....s.h...s....h....h...p...p....l.t......t.....L...p....p..h........h........t......p....h...s.....G..sh.....l..E........p..K.t.hul...sh...HY...Rp......A..s........p..c..................t...t.p.....tl..h......pt...h....p.p..h..h..t.....p.h.....t.l.p......lp..t..G..+....p.....l.lE......l..+..Pt........sss..KGp....Al....ptlhpp.hsht.............................................sp.hslhlGD.DhT..DEsuFtslpph........................sh...s.h.h...lhtst...........o.A........s..............................................................................................................................	0	327	667	904
+4726	PF03973	Triabin		Triabin	Finn RD	anon	Pfam-B_20829 (release 7.1)	Family	Triabin is a serine-protease inhibitor.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.90	0.71	-4.55	4	329	2012-10-03 08:47:39	2003-04-07 12:59:11	8	4	13	3	2	409	1	140.20	25	76.19	CHANGED	Ap....s.hMP.Gs.p..tchhssFchpcFFs.scWYlTHucsss+PplCpcapsous.c.........clpas...htS-VpCpsspVpGtcG..aSFpCcsss.....pcFpu.hoVluTDYcNYALlhRCspa.pSshcDsaLVhpRpKpus.Puulpop	...............................................................................................ttt.................tshpsFsspcF....ap..u......pW...Y....VT..H....s....p.....p...s.....o....p.....s..s..l..C..+..p..a.p..s.s.pp...sup..h.hs....hp..a..s.h..s..t....ttt......p.......l....pC..p..s..p....t.............p..p...t....p....pt......h....sFsC........p.....s....ss...........................hph.....p..h.....h.s.llsTDYssYAlhY..RCsph....s...s...t........h.....p........D........N.h.LlLpRp.t..s.t............t.........................	0	1	2	2
+4727	PF02080	TrkA_C	TrkA;TrkA-C; 	TrkA-C domain	Mian N, Bateman A	anon	IPR000309	Domain	This domain is often found next to the Pfam:PF02254 domain.  The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1].  The domain is predicted to adopt an all beta structure [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.04	0.72	-4.38	181	18298	2009-09-12 01:06:25	2003-04-07 12:59:11	16	80	4247	44	3835	11843	3990	69.60	20	21.79	CHANGED	lhphplst.ss..lsG.cslp-.ht....ltpt.....shhllul..p....Rs......tthhhPss.sthlpsGDhlhlhuptps.lpp..htphhs	........................h...h.l.t.ss..hsG.+slp-..lp.........ltpt.........sshlsul....h...................Rs..............sphhh...Ps...s...sshlp.tGDhlh..l..h.ustpp..lpp.ltp...............................	0	1256	2566	3307
+4728	PF02254	TrkA_N	KTN;TrkA-N; 	TrkA-N domain	Bateman A	anon	Pfam-B_289 (Release 5.3)	Domain	This domain is found in a wide variety of proteins. These protein include potassium channels Swiss:P31069, phosphoesterases Swiss:Q59027, and various other transporters.  This domain binds to NAD.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.38	0.71	-4.09	219	14934	2012-10-10 17:06:42	2003-04-07 12:59:11	13	58	4445	85	3537	12367	5545	116.30	21	31.04	CHANGED	llllG.hGchGttlscpLtp.s.p...................llll-pst..pp..lpph..p.pph...h.........slh.GDuocppsLpps.slppsc..sllss...hs.......s-....psslhsshhs.+ph.st..hp...ll..A+spstpp.....tchl.pp..hG.....s..ctllsP	..........................................................hlllG..h.G.p.h.G..t.tlucp...Ltp.pt................................slhll....-....p...s..t.......pp.............lp...ph......p..pph......hp.....................slh..G.D..u.s..c.........c....l......L..c.....p...u....u....l........p.......p....s-.........hll..ss...ss...................sc......psshhsshhs..+p...hhst.........hp.........ll....u+s..psspt.........hph...l....pp.......hG.........h...s.hl.................................................................................	0	1086	2338	3026
+4729	PF02386	TrkH		Cation transport protein	Bashton M, Bateman A	anon	Pfam-B_529 (release 5.2)	Family	This family consists of various cation transport proteins (Trk) and  V-type sodium ATP synthase subunit J or translocating ATPase J EC:3.6.1.34. These proteins are involved in active sodium up-take utilising ATP in the process.  TrkH a member of the family Swiss:P76769 from E. coli is a  hydrophobic membrane protein and determines the specificity and kinetics  of cation transport by the TrK system in E. coli [3].	19.60	19.60	20.00	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.98	0.70	-5.88	26	6295	2012-10-03 11:11:44	2003-04-07 12:59:11	11	18	3786	2	1475	4562	3549	309.50	23	66.68	CHANGED	pluttphpuhpphhphlhhhhhhhchlutlhlslhhlhhhthtts..............................h..ha.AhapohSuhssuGhSlpssS.hssFss..shhlphlhshhhlhGu.huFslhhchhhhhh.t...........h..hhhahtsh.hcshh.Llhhuhhslhhhphhssh.................................htthshstplhssaFtssssRTAGFoshDluphssushlhhhlhMaIGussuoTuGGl+ssphthhltsh..........pthhpt..........................................thpstpattcplppphlh....cshhlhlhhhllslspshhL.hhtpss....hhshlFEssSAaGTVGLShGh...............ssshohs......uKlllIhhMlhGRlchlshllhhshhh.	........................................................................................................................................................................................................h.......t.hht.h.h....hh.thhh..phlu.t.hh.hs...h..h...h.l...h..h..h...h..h..h..t.s.............................................................................................ha.p.ulhpuh..Ssh.....ssuGF...s.hh......s......s.......S.....l...h.........ass........h.lphl.lshhlllGG.ls...F...s....l.hh...p..l..h..tt..t.t.............................................h.pha.h+.....s...hphhh....ll.hh...u...h..h..hl.h.h.ht.h.hthh.........................................................................................................s..h..s..h.t...s....h.h.h.s.s.a.h...s.s.s.s.pTuGF.s.o......h......D....h...s.....p.....h....s...........h..s..........h....lh.h.....hhM..................F..IGus..sGST...u...GG...........lKshp.hhllhhhh...............h.h.h.h..p..............................................................................................................th..s..hh.h.....s........+...tl....s....p....c....h..lp........psh.s.h.h.h..h........h........h.h.lh.....h..h........s.......h...h...........h........l..................h..........s.......s........................s....................................h.......shh.hp.s....hS................A.husl......G.......u...h....G..h......................ss..shssh...................uKhllhhhMhhGRlthholllhhh............................................	0	480	956	1266
+4730	PF02005	TRM		N2,N2-dimethylguanosine tRNA methyltransferase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This enzyme EC:2.1.1.32 used S-AdoMet to methylate tRNA. The TRM1 gene of Saccharomyces cerevisiae is necessary for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNAs [1]. The enzyme is found in both eukaryotes and archaebacteria [2]	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.29	0.70	-5.54	10	846	2012-10-10 17:06:42	2003-04-07 12:59:11	11	9	491	7	551	1753	342	314.40	25	78.44	CHANGED	Gcu+lplsct..ho........lsstssVFYNPtMcFNRDLoVsl........LsshspKhh................................................hplLDALSASGIRuIRaA..LEhsslcclaANDlsscAVEhI+cN......spLNsls.......-.hllhNpsDANhlMt...pppctFcsIDLDPFGSPuPFlDoAlpSlccp.GlLsVTATDsAsLCG.saPcsCh+KYs.AhsL+s-hCHEsGLRILlshlsptAAKYc+ulcPLLSaSpDHYhRVFV+l+cGst+uccshcphGalhaC.tC..........hp....cpssGhschp........scCtaCGschpluGPlWlGPL+DccFlschlctscs.....ttph..pc+lhtlLphlc-E..lDsPhaYshspluphlKlssPPhpcllsuLtphGFcsStTHhsPsuIKTsAPhcslh-lh+	...............................................................................................................................................................................................................t.............................t.sFaNsh....t....h.....NR.Dlsh.hs............................t....h..t....p.......................................................................................................................................................................p.hL-uhuu.oGl........RulRas..hE............................h..........p....lh.h..ND..............hs.tu.hp..hptN...................hp..hNt.ht......................................h...p.........DAph...h..h............................p.ac.hlD...lD..P...a..G..o.....s.....ss.al-u.Ahp.s..l.tp....t.Gl.....lhlT.sTDhush...s.u.t..chs.hthY......u......u.................h....p..t...h...pE.....h.................ulRlllt.ltptAsphthhl.Pl..h.uh.h.ca..a..hRlhlclh.pu...t.....s.....c.....t.p.....hhh.C.....C......................................................................................................................................ts....s....s.t.....p....h...h.hGPha.sslts.taltph.ht...t.....................h................ph..t.hlph.h....p..........E.......t................s.h.aa.p..p.phsph...ht.h.t......h...hhtt..l.p.GapsohoHht..u.l+TsAs.t.hhth.........................................................................	0	165	299	437
+4731	PF00133	tRNA-synt_1		tRNA synthetases class I (I, L, M and V)	Sonnhammer ELL	anon	Prosite	Family	Other tRNA synthetase sub-families are too dissimilar to be included.	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	601	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-13.17	0.70	-6.52	15	21195	2012-10-02 18:00:56	2003-04-07 12:59:11	17	120	5058	69	6103	31264	24036	374.40	23	54.93	CHANGED	shhphWpctsh.FctshptsKs.pts..FslhssPP.sTGplHhGHALspoLpDhllRhppMpGass.ahPGaDptGlssptpVE+KlutcptpshhchGpEcFhscshcattEassph+sphp+LGhhlDas+-hhTh-.phppuVhclFscLaccGLlYRGp+lVsWsssspTALS-hEV..pYKDsc................ushhalsasl......s-ups........plllhTTpP.Tl.ussAlAVpP-........................................-.+hpcLlGpphphPF.......hsRchPllsD.-aVch-tGTGsV+hsPAHs.sDYplGp+asL.....chlNsls-sGshs-ss..................scapGhchFcAcKtllcpLpEpGlLlchcshpHShPaC.RossPl.hhhosQWFV+hcs.......Lscsulcslc....clpaVPcp.tEpcahsWlcNhpDWCISRQhaWGp.IPsWhsc-ssElas....h.ph.tsp.ppcsppshhth.hhchl............phcpssDVLDsWFsSG.hPauslsaP.s.sst-acphaPsDhllpGhD.hhhWhtphlhhuhthpGps......PaKpVlsHGllhDupG+KMSKSlGNslDPh-llc.....................................paGADALRhaLh.sossupDlphS	..............................................................................................................................t..........................................................................................................................................................................................t..t.p..............-....t...................t...........................................u..c....u...........hs...h......................................................................................................................................................................................................................................................................................................................................................................................................................................................u...........t..h................................h.......................................o...................................................................................h................t..h............t............................hs...................sh........p..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................DWslSR...Qh.h....WGh..lP........h........h........h............t.....p..................t.................................................................................................................................................................................................................................................................................................h..............p........-.h...h.....D.....s....a.....h...........p.........S...........s........h...............h............t...........h.......h...........t.............................................................................................t...............................................h......................p...........................................h..........P........s...s......h....h.....h.t.....G...-..............h.......h....h......a......h...................h........h............s......h...............h.........t..p..........................................P...a...p..........p...l...h...........p...G...h...h.....h.....s......t.........t.........t.......p........K...M.SKS.....h...sN.s..l.s..P....p...h...h.p............................................................................................................................p.h.G..s..D.....hhRhh.h....s.............................................................................................................................................................................................................	2	2043	3764	5105
+4732	PF00749	tRNA-synt_1c		tRNA synthetases class I (E and Q), catalytic domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_350 (release 2.1)	Domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	19.80	19.80	19.80	19.80	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.86	0.70	-5.77	18	10836	2012-10-02 18:00:56	2003-04-07 12:59:11	16	90	5178	51	2955	8426	5158	287.60	31	62.06	CHANGED	cV+TRFsPpPoGYLHIGpA+sALhNahaA+pasGphllRh-DTssc+pp.EhtcuIh-slcWLGlchp..........tshhpS-+a-thhcastcLIccGhAYhsasosEcLcphRcp.........phs..tps+hsccsLpLa.E-hpptptpstttslRhKlshpus.hshcD.Vthclphss.........cchshsKhcshPTYcFssslsDtl.pITHslRspEahsssspahhlhcAluht..ssat+.hhhlNhssphLSKRKhshh..hphhcshs....shlshLt+hGaos.....puhcEhhstptlhcph.hsh.scuhttFspccLph	.......................................................lhsRFAPSPo..G....hLHlG.....ps+o.AL.hsah....h.A........+................p........h......s....G........p....h.........l......L..........R....lEDTD...t......R......p..s.........c..hhc..................s...............Ihcslc.W.......L..GlcWD...............................................ttshh.Q.Sc.R..h..-..h..Ypphhp...pL....l.p.........p.G........hA....YhC....h....so.t.E...c..l.ct...h..Rtt...........................sts.....................t......s...p......Y.......s.....t......c......s..h......p..h....h.............t......p......h.....t....t....t....t....h....t....s.t....t.s....s.lRh.........+......h.......s....................s..........s.........s........h.........t...h..........c.......D................l............t............G...........c...........l.......p..h.....s..s..t.................................h..c..Dh.l......l.......t.+.......t....c..........G....h....P.........s........YshusslDDth.s..ITHllRGp-als.s....s.s...pp..hh..........l..........h...c....s.....l...............u...............h..................t..................s.......P..........................a.t.H.h.s.h...h...l....s.......s.................t.....p...+LSKRc..........t...............s..........h..............................................................t.........................h.c...ths.........sh.l.s.h.l.t.h.h.G..as.......................t..u...p..p......hhp......h...th.............hp........t......tt.thh..pcL...........................................................	1	979	1835	2473
+4733	PF03950	tRNA-synt_1c_C		tRNA synthetases class I (E and Q), anti-codon binding domain	Bateman A, Griffiths-Jones SR	anon	Pfam-B_350 (release 2.1)	Domain	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only glutamyl and glutaminyl tRNA synthetases. In some organisms, a single glutamyl-tRNA synthetase aminoacylates both tRNA(Glu) and tRNA(Gln).	21.00	21.00	23.00	21.50	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.49	0.71	-4.59	111	2972	2009-01-15 18:05:59	2003-04-07 12:59:11	13	80	2452	17	1073	2415	678	183.90	39	29.60	CHANGED	AsRhhsVh...cPlcls.lss...h.....s........t..phchshHPpp.schGpRplsau..p...plaI-psD...........h.pcLt..G.ppVRL+t.hhslcs.pcl..p..sGplhp..l.sphc..spohtts......h.Kscu.hlHWVus....ppu.lss.phh.Y-pL...hp.........p.t..........thl......lNPcShthh...puhsEssl...tshphssh...hQFERhGYaplD	...............................APRtMAVl.....cPlKll..IpN..a......................sts.............psEhlph.ssHP............p...p.....s............-...h.G.....s....Rp.lPFo..p.....ElaI-+sDFhEp............................................................ssKpatRL..s.G..pEVR.L+s.u.Y.l.I.c..............s..pc...l..........KDs....s.Gslsp.........lhsoYD.....s.-.ohutss........................psRKVKG..sIHWVSu...............scu....lss...ElRLYD+.L.Fs...............................s.p.Psst.....................chl.....lNPc..SL..hhh....ppuhsEP.u.l.............ts.s...t......s.t.ct.............aQFER.GYFssD.........................................	0	358	646	899
+4734	PF00750	tRNA-synt_1d		tRNA synthetases class I (R)	Bateman A	anon	Pfam-B_1276 (release 2.1)	Family	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only arginyl tRNA synthetase.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.18	0.70	-5.63	9	5698	2012-10-02 18:00:56	2003-04-07 12:59:11	14	23	4847	14	1682	4669	4137	317.60	27	59.58	CHANGED	hlsslLspstph..stthpppcVll-FsSsNsst.hHlGHlR.shlGDuluRLhEhhGasVlRt.alsDaGsQhshhhspL.pttptphosp..ltphpshYttshhch.s-El.......ht.cthphlshLputspp....apphhsp.lh-hh+pphpchhsshDVhhhE....uE..hhpsphschlpcL+cpGhlhEpDGAhhlhssta....G-shsh.lllKSDGshsYhssDlAhhhp+h.pcthDhhlYhlsscpcsahtphaAAspthG.asPc.ssclhtls.hVsLscDtc..+hppRuGssVpLsDLL-.............................uIGlsAs+Yu.lppspsosh.hDh	..............................................................................h....hhtt.ttth..........t.....s.ps.p.pl.h.l-asSsNsst..s...hHlGHhRusllGDulspllc....hhG.a.p.V.h..............+t.alsD..............hG.....sQ.h.......................s..h..L...h.....h..........u.........h.............p......................t..........h..............h.......p.......c...............t........h............h..................................t.....................................l.......s...........t.........h...............t...........p.................h........Y....h......t...t...........p...........h............t................................t...........c.................t...............................................................................................................................h...........t...........p...............p...................u...p......p............h..h...h.................p.h.........p.....s.s.c..tp..............................hp.ph.h...p....p........h...h....ch.............h....p....p....h....p...p....h.....h....s....c....h....sl....h..h.pc.................uc....h..h.....s....s.....t......l....t......p....s.l..p.t.L..cp.p.....G.....h.........h.h...............E...............p............-..........G..........A......h...........h.......l.......p.h..s.....p.a...........................G.c.s..h...s..h......l..lh.K.s...............D......G......sh.hYhs.s.............D..lAhth..+h.............p....h....t...h..c...c..hl.hlhu..scpp.......tahtplhs....s........hct....h........G.....a...........s..................p.....sh....p...l.........h.l....s..........hhh.............h..........h.............c......s...Gc......................thpsR.p..Gs.sl..pL..c-l...l.-E.s........h.p...t......s....h..........h...............................................................................................l.uhsu....lha......lp.ph.pth.Fp........................................................................................................	0	587	1058	1400
+4735	PF01406	tRNA-synt_1e		tRNA synthetases class I (C) catalytic domain	Howe K, Bateman A	anon	Swissprot	Family	This family includes only cysteinyl tRNA synthetases.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-12.00	0.70	-5.30	11	5726	2012-10-02 18:00:56	2003-04-07 12:59:11	14	22	4818	10	1568	11552	7784	301.80	46	64.24	CHANGED	.hsslcptpVshYlCGsTVYDhsHlGHuRshlsFDllRRhLph.hGY-VpaVpNlTDIDDKIIp+Atpptpo..................................................................................................................hpplscpaIpsapcDhcALNVL.PshcPRsT-alscIl-hlppLlc+GaAYsus......GDVYFcVsshcpYGpLSspsl-pLctsspsts.......ttK+sshDFsLWKuuKsGE....suWsSPWG+GRPGWHIECSsMsschLG.....splDIHuGGhDLhFPHHENElAQSpAhas.tphspYWhHsGalpl-sEKMSKSLGNFlpl+DhLppa-schLRahhhssHYRs.L-aoEphlppAps	....................................................................................................................PlpsscV.pMYVC..G.sT..VY...s..h..s..HlGp.A.R.........s.h.l.sFDl.lpRa...Lch....hG.Y.c..V...........p....YVpN....l.T..D.........l................D..........D...K.....I.I.....p+..Ap..cp......u.........s.........................................................................................................................................................................................ht..p..l..s.c.+.a.l.p..t...apc..DhsA.....L.s..l.h............P......s...........h....c........P.....R........A...T....c....a..l.......s.......-..h..I..p....hl.c....p......L.l.c.+GaA..Ytus............................GDVY.F.....c.....l.....p.....p.........h...............t.......s.......Y.........G.....p..L.....S...t...........p..s.l..-....-.....l.p..s..G.u.c.s..css..................................p.pK+s.PhDFsLW.K.s.......u....K............s...G....E.....................su...W...s..........S.....P.........W........G.............p............GRPGW...HIECSAMup..chL.G.................s.p....hD..IHGGGtDLhFP..H..H....E.......NEI.AQ.....S......c.............u..........s.............p.................s......p................p.........a..........s....p......Y...W....h...H....s...G..h..l..p..l.......c....s..........E.................KMSKS.....L.GNFhT.......l.......+-.l........L................c................p................a.....s........s..............p................s......lR.aa.h.l..s..s..H.Y..R..s..slsaS.c.csLppA..t.........................................................................................................................................................................................................................................................................................................................................................................................................	2	550	1024	1339
+4736	PF01921	tRNA-synt_1f		tRNA synthetases class I (K)	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes only lysyl tRNA synthetases from prokaryotes.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.25	0.70	-5.78	39	631	2012-10-02 18:00:56	2003-04-07 12:59:11	13	4	615	2	222	4907	4602	353.70	38	66.72	CHANGED	ttWs.p.Accll.cRhpt.....s....phlhpTGhuPSGhsHIGsFt.EVlpsshVt+Ahcph.utp......s+llhhuDDhDsLRKVPc...NlPsp..hppaLGpPLoplPDPa.Gs.ppSaucHhpt.hpchL-phGh.-hEahSuo-hYpuGhasctlhhsLcp....h-cIhcIl..hhscc....hpts...........................a.PahPlCscsG+lhps.lhshc.ptsplpY.s............csGcphpsslpsGt.........sKLpW+lDWuhRWtuLuVcaE.hGKDhts....ShshuscIs.clhGtcsPhshsYEhhh.c...ssp......KhSpSKGsslolc-WLchusPEsLpahhhp.cPppthclphc.sl.+hlDEY.ph.cta..........ppstppphtsslaclppsp	...............................................................................................................................................................tWs.c.Accll...c+.tt.........tp..............hlhp.oGhuPSGhsHIGsFt.EVhpsshVt+Ahcpl..upc.......oRhIhhuDDhDs...hRKVPc.............Nl.....P...s.p..th...........lt.pals.hPLoplPDP............a...G......s....apSaucH.pshlpphL-pFGh....-h.EFhS.uo-hY+SG..tacptlhpsLc+..h-cIhclhh.hh....sc-.....cpts.........................................................................Y.Pa.hPlCscsG+lhp.s....s.lp..phDs.pssTlsYcs.........................csGppt...plsl.s.s.Gp.........sKLpWKsD...W...s.M..R.Wsshs..VD..aE....h..G..KDHts....Shs....l.u.....scIs...c..IhGs..c.s.P.....t...h..s....Y....E...h..h...h...c...ssp.........KlSpS+GN.ulolc-hL......c.h.s..s....s.Es........Lt.h.h.h.h.p.......+...P.p..p..A.h.+.l...h......FD................s.I...s...+.s...h...D...E.Y.phhptYh...........ppphcpphtp.saclp...s.......................................................................	1	67	145	176
+4737	PF00152	tRNA-synt_2		tRNA synthetases class II (D, K and N) 	Bateman A, Sonnhammer ELL	anon	Prosite	Family	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null --hand HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.02	0.70	-5.67	107	16099	2012-10-02 14:22:40	2003-04-07 12:59:11	15	73	4974	111	4475	12333	7486	357.10	28	69.99	CHANGED	sc-hRLcaRaLDLRpsphpp.tlphRsclhpslRpahscp.GFlElETPhLspussEG......ARsFlVss..............tpaau.....LsQSPQLaKQlLhluG.h.-RhapIu+sFRsE-h...+scRps.EFTplDhEh..uFsstc-.lhplsEpllpplhc.ph.h.......................slcls..........F.Rloap-Ahcpauu-c.sDh+h.th....ph.p.htph............t.thphht..............................................................................................t....htphhstlhtch.......scc........tlh....t.pthphhalsDaPhh......p......................+PFst..spp...ps.......................shucsaDlllsG..hEluuGuhRlpc.chQpphFcthshs.....tcp..thFsahLcAhca.GsPPHGGlAlGlDRLlMllsstpsIR-VIsFP+spp	.........................................................................................................................................................................................................................................................................................................................................-h+hc.RaLD.L.h.p.s..p.t...............t...s....hphRupl..hpslRca............hs...pp...G.......Fl-lE.TP......h.......l.......s.......t.....s...s.....s....pu..........tA+sFhsp.....................................p.hhs......hhLt.........S....P..p.........L.a.....hc......h........L..h....s..u.G......h....-.......+..l..apl.......u......+.sF..R...sE...sh..........s..s..R.HssE..FT..........l-.h..h......u.....a..h.c..h...................p.............-.....lhs..l.s..E..........s..hl..ppl.hp.pl..h..........................................................................thphs..............ts..F.+....lo...a.p-.A....hcp.....h...ts......pp..............c.hc.............th..t..htth..........tth.thph......................................................................................................................................................................................................................................hGtlhsph........hcc.......lh.........-pp.hhpPsalhc.aPht.......h.......................................................pPhst.....ps....ps.s.........................................................................................thsptaD.l.hl.sG............hEl.us.G.pclpcs..c..Q..p...p.pFct......s.hs....................................p--....t............h....t.alc.A.h.cY..G.....h.P.Pp.u..GhulGlDRLlMll...ss....t....p...s.....IR-VIhFPph.......................................................................................................................................................................................................................	0	1514	2790	3758
+4738	PF02081	TrpBP		Tryptophan RNA-binding attenuator protein	Mian N, Bateman A	anon	IPR000824	Domain	\N	20.50	20.50	24.40	25.60	18.10	17.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.55	0.72	-4.55	10	142	2009-01-15 18:05:59	2003-04-07 12:59:11	10	1	138	252	55	115	0	73.50	64	97.61	CHANGED	Mpssp..suDalVIKAlEsGVNVIGLTRGoDTKFHHSEKLDKGEVMIAQFTEHTSAIKlRG+AhItTsaGplcSEuK	......h....tsuDYlVIKAlEsGVsVIGLTRGpDT+FHHoEKLDKGEVhIAQFTEHTSAIKlRG+AhI.TpaGplcS-.......	0	27	44	48
+4739	PF00587	tRNA-synt_2b		tRNA synthetase class II core domain (G, H, P, S and T)	Bateman A	anon	MRC-LMB Genome group	Domain	Other tRNA synthetase sub-families are too dissimilar to be included. This domain is the core catalytic domain of tRNA synthetases and includes glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.26	0.71	-4.68	112	18502	2012-10-02 14:22:40	2003-04-07 12:59:11	20	111	4989	173	5461	19073	11934	180.70	25	33.50	CHANGED	lpptlhphhpchhp...p.GapcltsPhlhppclhpt.oGc.tphhcc...hap...h...........pcttt........c............p......h..........................................................................................................hLpPpsp.slsthatpphhp.hpp..LPl+hhthush.aRpEh....psp.GlhRhRpFpps-hhhass.s.pp..............................................s.pthtchlphhpplh.pp...lGl.........saclh.sspsshst.tppphshcsah.sp	...................................................................................................................................................................................................................................................................................................................ctlpphhhcphp.....ct.G......a.p..ElhsPh.lh....s.t.....c.lapt...o......G..+...h...s..p...a...s..-s.....h...ap....h..................p.s..tp..................................c............p......h...............................................................................................................................................................................................hLtPp...sp....sh.ss..h........ac.s..........p.l...p.............S....................h..+............c.......L...P....l.....p.......hsp.h...u...s......s.a.....RsEh.......pstpGlh..R.....sR..p.F.p.p.t.......-.ta.h.F..sp..s..-p..........................................................................................................hp.c.php.p..h.h..s.h.hp.clh...pp......h..Gl...............sa.+.h..h.h.ts.p..s.sh.u.h....s.u.scpach.ph.....t...........................................................................................................................................................	1	1884	3455	4605
+4740	PF01411	tRNA-synt_2c		tRNA synthetases class II (A)	Howe K	anon	swissprot	Family	Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.	19.50	19.50	19.60	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-12.92	0.70	-6.22	25	6692	2012-10-02 14:22:40	2003-04-07 12:59:11	14	24	5160	30	1902	5657	5079	441.50	35	60.86	CHANGED	ElRppFLcFFc.c+G...HphlsSusllPc.sDPoLLFsNAGMspFKslFLGtt.....psshsRAssoQ+CIRsGGKHNDL-NVGhTuRHHTFFEMLGNFSFG.....DYFKcEAItaAWElLT..ph.....asls.-+LalTVapsD-........EAhslWpchs.lPcpRIl+hstc.......DNFW.....pMGDs.............GPCGPCSEIaYD+G.chsst.sus.sp....-ssRalEIWNLVFhQaNRps......cGshpsLPc+slDTGMGLERlsuVLQshpsNa-sDlFhslhpthpplouh...s........spsthphuaRVIADHlRulsFhluDGllPuNpGRGYVLRRILRRAlRau.+pLGhcps.FhtcLVssllchhGssaPELccptshlpcllcpEEppFt+TLcRGhpLlcchlpphpp..spslsG-suF+LYDTYGFPlDLTp-lAcE+GlsVDhpuF-pshpc.p+cco+..pstpstt.....hthshpsltcltss......s-FhtYsph.............pspuplhulhp.sschlspltt.Gppsh........llL.DpTsFYAEuGGQluDpG...hlpsss....scFpVpssQchs.uhllHhGpl..ppGs..lplGDpVpuplDppR	......................................................................plRphalpaFt.p..p.s....H.h..............Sssll.P..sDsoLLahNuGhs........h.K.hF.G.................................h.........R..hsssQ+sl....Rss....Dl-sV.GhT.s..RH..pTFFEM..LGNFSh.G.................DY..F.K........c....-AItaAWEhLT.....ph.....hths.-+LasTha.....t.....Dp........................EAhplWtp.............................l...........stp+Ih.h.......p....................DNFW........phGt..............G.PCGP.soEIaaD..+..G......t..hh..s...t...........s....t........t....................-ss..RalElWNl.VF.Q....asc..pt......................................ps..p..h.p.L.P.p..s.lDTG.MGLE..Rls.........ul.........hQ.........t.........hp..........sNa-hDla.hsl..lpthtph.ss....................................................t.t.ts.huh+VlADHlRshsahluD..G..shPuNpGRGYVLRRllRRA.....h....Rau......p......h...L......G............h..............p........t........s......a.....h.hcLl.ss.......l....hp...........h..........t....t......h..a..s..-lh.p.........p..t..t......h.....ltph...lp...tEEppFh..c..........T...............LppGh......tl....hpp............ltp..ht...........................tphls.Gp..sFc.L...a..DT..YGFPl....-LTt-h......h.p.-............t.s..........h..p..lD.t...sFpt.tMtt.Q+.......pcu+...tstt.tt.................t.......t......h.......p...h....t.....................sphhsYp.t...............................p.h.p.u.pl.h.t.l.h.........................p........s.............t..........s........p...t...h.....p........t.....u..p..p..s.h....................ll..L..-p.TPF.YAE..uGGQsuDpG.............hl...t...s..ts........................h...h..t.V...t..D..s..p...+.......h......s...s.......h.......h.h..H.h....s.pl.......t...........u.t........l.....p..hGpt.lphplD............................................................................................................	1	653	1183	1586
+4741	PF01974	tRNA_int_endo		tRNA intron endonuclease, catalytic C-terminal domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.	21.10	21.10	21.30	21.80	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.66	0.72	-4.18	78	852	2012-10-11 20:44:43	2003-04-07 12:59:11	12	20	456	40	569	852	86	86.70	26	27.42	CHANGED	F.h+ahVY+cLRc+.Gahl+sGhK......aGsDFtlY........tttsshsHucalVh............l.lspspth......................shpclhptsRlupuV+KphllAhl.....sppsc.......lsa	..........................hpYhlY+cLRs+.Gahl.p..sGhK............F.GsDal.lY.........ttsPhhhHupa.hVh..................l..h.s.......s.cph..........................................sht.p.lhshsR...lussV+Kphllshl.....p................................	0	178	316	463
+4742	PF02778	tRNA_int_endo_N		tRNA intron endonuclease, N-terminal domain	Enright A, Ouzounis C, Bateman A, Griffiths-Jones SR	anon	Enright A	Domain	Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.37	0.72	-4.42	65	347	2012-10-01 20:02:48	2003-04-07 12:59:11	9	7	240	33	209	357	30	66.70	25	25.64	CHANGED	hpuhL.sspVllt.....s.csspp...LacpuaYG+.............hpsphLpLSllEAhYLhp+.Gtlclh....pptchlshcclh	..................................h.h.tt.lhh........t..pp........lhpp...shYGp........................................h.tphLpLSL.EAhaLshp.GpLplh......ptc.lsh.ph...............	0	50	112	158
+4743	PF01746	tRNA_m1G_MT		tRNA (Guanine-1)-methyltransferase	Bashton M, Bateman A	anon	Pfam-B_2049 (release 4.1)	Family	This is a family of tRNA (Guanine-1)-methyltransferases  EC:2.1.1.31. In E.coli K12 this enzyme catalyses the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA [1].	21.50	21.50	22.40	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.96	0.71	-4.70	23	5148	2012-10-01 22:53:19	2003-04-07 12:59:11	16	19	4707	18	1419	3601	2980	190.20	39	74.76	CHANGED	hpph.c+clsplphpshRsasts++phsssphahsuhshhhKhc..h.thp............shpshhlpsps..h.pphh.pl....pp-....cllhLsuchEsh.pclpppt.......hasIGshV.psschss..hhstththh.Glh..st.pL.h-sa.......llttPth....o+shs..lp..pV.-lLLpspc..hpsW..cpulhcshspR.	..................................................................................h.s+AhcpsllplpshshR-asp.s.+.Hp..p.V.D.D.p..PYGGGs.....GM.l..hp....s..p..P..l...hsAlcsh............pt.........................pts+l..Ihh..oPpG....c.hs.Qph.sp-.L.............u.p.p.p............................cL.lhlCG+Y.....E.GlDE...R.lhpt.hss...........pEhSIGDYVLoGGElsA..hshh..DulsR.llPGVL..Gppt.SttpDSFs........................sGLL-hPpY..........................TRPts..acG........hpV.P.-V..L.....lSGsH...t..pIccWR..hcpuLt+Th.+RP.......................................................................	0	488	884	1178
+4744	PF03054	tRNA_Me_trans		tRNA methyl transferase	Griffiths-Jones SR	anon	Pfam-B_823 (release 6.4)	Family	This family represents  tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside  5-methylaminomethyl-2-thiouridine present in the wobble position  of some tRNAs [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.24	0.70	-5.90	21	5331	2012-10-02 18:00:56	2003-04-07 12:59:11	11	13	4511	6	1265	6684	5283	320.80	41	86.58	CHANGED	t+VlVuhSGGVDSSVuAhLL+cQG.apVlGlaMcpasp...t-phs.........tCsutcDhpDAp+lscpLGIPhhhlsatccYhpcVhp.Flc-YppGpTPNPDlhCN+pIKFuhhhchshp......LGsDhlATGHYARlshs........................spstLtcuhDppKDQoYFLsslscctLppllFPLGchp..KspVRplApctuLt...sAcKKDSpGICFlucps...accFLpcaLssp..pGsIlchc.....GpllGcHcG...hahYTIGQR+GLslut....htcPhYVlcKDscsNplaVup...p.tLhpcplhspphsWhs.....thsst..hpsps+hRapp...s.hpsplphhss.tplcVpFcpshpuVoPGQssVhYps-....tsLGuGhI	..........................................+VlVuMSGGVDSSVs.A.h.L..L.p.c...p..............G...Y...c..........V.h.G.l..aM.+......Wcc.................scppt...............................hC...s...u...t...pD...h...t.D...A...pt...V...s.c...p.l.G.I......s.....h.a.sl...s..F.t...p.c..ah-p..V...hphFl.s..E..Y.p.t..G.RTPNP....s....lhC.N..+......c.I..KFp..shL-hAhp.................L..G..AD..h.lATGH..Y.uRht.p..t......................................................sst..h.plh+u....h...D.....s.sK...DQo.YFLhpL.spc..QLt+shFP.lGc..h..p.........Ks...c.....VRc.lA.p.c..............h..............G......Ls......sAc.KK.D........SpsIC..F.Is-p.p............app.FL..p...p...................a....l.....s.....s.....................p.......sG..p.....h.h....sh..-.................................G.chl...G.cH...p...G................lhaaTlGQR.+..G..LG.....Ius....................stcP..ha.Vl.shDh...p..pN..hlhVu.p...........c....t..L.hspt..l..h..s..p..p..lpahs......................p..p.......s.h..cs.psKhR..Y+p....................tsh........s..p...l..................p..........h..........h..........s..........-.........t.................p..............h....pV..h.F...s..-..P.t.....A...lo..P.GQu.sVaY......p......u.-......hsLGGGhI................................................................................................................................................	0	456	838	1088
+4745	PF04558	tRNA_synt_1c_R1		Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1    	Kerrison ND	anon	DOMO:DM04413;	Family	This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli.\	      This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function [1].	25.00	25.00	25.50	25.30	23.70	24.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.84	0.71	-4.72	27	278	2009-01-15 18:05:59	2003-04-07 12:59:11	10	19	200	1	172	258	0	152.70	33	20.99	CHANGED	sss--LhpLFpplGLs-pKu+EhlKNpKlossLpsllppu.sss..sshs+pptsLLasLAo..ph+ssp....hs+pshllphIhsuclKTshQlsAAhcalpspss....shsssch-ctsGV.GV.VT.--lcptVsphlppp.KppIhpc..RYp.hsshhhhscttspL+WAcsp	...............................c.h.pLFttlGLsEpKA+EslKNp.plossLtphlppA.....tts.......sshs+s.....sGsLLYslAo....+l+s..st......+h.shl...lpaIsspKl+Ts.Qls..AAlcYlpspst...tsl-tscF-ctCGV.GVhVTsEpIcpsVpphl..ppp..+tplltp..RY+.hs..hshlh...scs+st...L+WADu.................................	0	70	103	143
+4746	PF04557	tRNA_synt_1c_R2		Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2    	Kerrison ND	anon	DOMO:DM04413;	Family	This is a region found N terminal to the catalytic domain of glutaminyl-tRNA synthetase (EC 6.1.1.18) in eukaryotes but not in Escherichia coli.\	\	\	  This region is thought to bind RNA in a non-specific manner, enhancing interactions between the tRNA and enzyme, but is not essential for enzyme function [1].	21.20	21.20	21.20	21.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.24	0.72	-3.29	23	240	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	176	1	146	227	0	84.40	35	11.22	CHANGED	hhKstlDhplLcLLGPKsEtDltKKpKps+.....sptstt.h.......sspspspss-ssscps.hhEthhG-...hHKPGEN.........Ppsh..Lhpc	......................lKsplDhplLcLLGPKsEuDLt.Kt.Kttc.................tphtp...................ttpsss...pssp.ssspst.h.Ephhup....FHKPGENhp...............Ppoh.hLppc.......................................	0	55	82	120
+4747	PF02091	tRNA-synt_2e	tRNA_synt_A;tRNA_synt_2e;	Glycyl-tRNA synthetase alpha subunit	Mian N, Bateman A	anon	IPR002310	Family	\N	20.00	20.00	20.50	20.90	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.97	0.70	-5.30	9	3035	2012-10-02 14:22:40	2003-04-07 12:59:11	10	8	2991	8	663	1810	1805	283.40	66	88.81	CHANGED	FQshIhsLQcaWupQGCllhQPaDhEVGAGThpPsTFLRuLGPEPWpsAYVpPSRRPsDGRYG-NPNRLQ+YaQFQVllKPsP-NIQ-LYLsSL+ALGIDshsHDIRFVEDNWEsPTLGAWGLGWEVWLsGMElTQFTYFQQlGGltCcPVosEITYGLERLAMYlQpl-slaDlhWs-u....lTYG-lFhpsEhEhSsYNFEtAsV-hLFphF-.a-cEAhphlc.s..LPLPAY-hVLKsSHuFNlLDARGsISVTERpRYIhRlRsLARtVActYhptREpLGFPL	...................................................FQplILsLQpYWu........c......QGCsllQPaDhEsGAGThHPhThLRAlGPEP.WsAAYVpPSRRPsDGRYGENPNRLQ+YYQFQVllKPSP-N.IQELYLsSLctLGlDPt.HDIRFVEDNWEsP..TLGAWGLGWEVWLsGMEVTQFTY..FQ..QVGGl-Cc.PV.o...uEITYGLERLAMYlQsVDSVYDL.Ws.-G.........................loYGDlF.+QsE.....hEpSpYNFEhADs-hLhppF-paE+E.....Appl..............L..............c..t.t...................L....s.............LP...AY-hlLKASHoFNLLDARGAISVTERppYIhRIRsLu+sVAcsYhtpRctLGFPh.....................................................................	0	211	416	543
+4748	PF02092	tRNA_synt_2f	tRNA_synt_B; 	Glycyl-tRNA synthetase beta subunit	Mian N, Bateman A	anon	IPR002311	Family	\N	25.30	25.30	25.50	26.10	21.50	25.10	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.58	0.70	-5.96	167	3055	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	2988	0	666	2359	2774	541.00	41	78.66	CHANGED	hLlEIGoEELPuchlpphhppltptlpptLpctpLsa..s.slcsauTPRRLAlhl.pslsppQ.sDtp.Et+GPshphAhstsG.sPT....cAAtGFA+up....Gls.......lcc.Lpht..p.........s.sKu-alhh.ppptpGpsstplLschltphlpsL.shsKtM..RW..G.......s.....t...shcFlRPl+WllsLhssc.....llshpl.......h.G....lpouphopGH.RFht.st..slpl.sssscYhptLcpp.hVlsDhpcR+phItpplpphA.ppt..s...sps.h-..-s..LL-EVssLVEaPsslhGpF-.ccFLp.lPtElLlooM+pHQ+YFslhc.p.sG...........pLhPpFlsVuNhpspc..ptlhpGNE+VlRARLuDApFFacpDp....KpsLpshltcLcpVlFpcpLGolh-KspRlptLAthlA..ptl.............s......s.....s...h.ppspRAAhLsKsDLlTpMVh..EFPELQGlMGphY.Ahts...GE....sptVAtAl....pEHYhPphuuDpLPpo.sGsslAlADKlDTLsGhFulGth.PTGSpDPaALRRuAlGllRIll-pp..hslsLppLlppu.hp.h....tt...............hstps.shpplhsF..hhpRlcshhp..cp.u.....hsh-llpAVlu...ts	........................................................................hLlElGoEELPs+slpshtcphtpphsstLcpstLsa..............s..s..l....p..hauoPRRLAlpVp.sLuppQ.s..Dpp.Eh+GPuhphAh...Ds-G.p...s....o.......KAApGF....sRup.Glo...........l-p...l...chh.p..........................s...cpsEalhhp.tp.ht.Gps.spslL.sshlspslppL.shP..KsMRW....G.................s.....s.....shcFlRPl+tlssLh....uc.c.....l.ls..hpl.......hG........................lpou+so+G..HRFh.......s......s...............t..phsl...s.sA..cpY.phLccp..hVIsDh................pcR+thIhpphcphA.pph........u..............s..ps...s..l..-....-s.......LL-EVsuLVEaPsslhupF-.-cFLp.lPpEsLlhoM+scQ+YFsVhc...p..sG.......................................+Lh.PpFIhVuN...hpscc....pplIpGNEKVlRsRLuDAcFFappDp....................K..........p.....s...L..p..s.....h.l..s+L..p..s..VsFpppLGolt-KspRlptlAshlAppl...................................ss-..sscspRAuhLuKsDLhTsMVh..EFs-LQGlMGtaY.........Apts.........GE.........spsV...AhAl....pEpYhPphAuD.pLPps.....l...usslA...lADKlDTLs.GhFulG.h.PoGopDPaALRRAAlGllR..........Il..........lc.....ps...........h.sls..Lpp.Llppu..hp.hh..ssp..................................................htsspshs-lh-FhhsRh+shhpcp..u.......hshDhlpAVLu.p....................................................	0	207	417	544
+4749	PF00261	Tropomyosin		Tropomyosin	Finn RD	anon	Prosite	Family	\N	35.00	35.00	35.10	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.67	0.70	-5.27	43	1328	2012-10-03 05:16:33	2003-04-07 12:59:11	15	16	401	54	388	1233	5	180.20	54	81.39	CHANGED	KKhpplcs-hDpspEplpcApccL-pp-KptpcAEuEVAuLNRRIQLlEE-L-RupERLssAhpKL-EApKAADES.ERupKVlENRuhpDEE+h-.LEtQLKEAKhlAE-ADRKY-EVARKLsllEsDLERAEERuEhuEuKlsELEEEL+lVuNNLKSLEsucEKuup+E-pYEEpI+.Lop+LKEAEsRAEaAERoVsKLpKplDcLED-LhspKE+YKsls-ELDpThsELsuh	..............................hp.ph-thp.pthtthppp.lc.....tc....cth.p..pA...Eu-VA...uLsRRlp.LlEE-L-.R..upERLsoAhpKLEEA.pKAADES...E..R..uh..KVlEN..Ru.h.pDEE+M-h....EhQLKEAKal.......AE-.....AD+KY-...EVA.....RKLsh.lEs-LERsE-RsEhuE..s+hh-LEEcL+.h.spsLK.uLpst........t-..........c..hsp+E.-pYccpI...+hLsp.+LKEA.....E..sRAEhAE.Rs.VtKL.pKplDcLE...-..p...lhtt+.c.hthpp.h-.sh.-h.......................	0	115	147	252
+4750	PF03301	Trp_dioxygenase		Tryptophan 2,3-dioxygenase	Mifsud W	anon	Pfam-B_4263 (release 6.5)	Family	\N	21.20	21.20	23.40	21.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.12	0.70	-5.33	5	1051	2012-10-01 19:57:26	2003-04-07 12:59:11	8	6	627	72	420	1075	498	187.70	29	87.19	CHANGED	-SsQsGspcsScu.GhsYGDYLpLDKlLoAQ+hlS-.ttp.lHDEHLFIVTHQAaELWFKQIlaELDolR+LLsss+l--s+.hLclhctLcRlV+ILcLLssQaolL-TMTPLDFsDFRcYLoPASGFQSLQFRlLENKLGV+supRl.YNtp.YpssFtss....chLLsoEcEpoLLcLlpuWLERTPGLc.pu.s..FWhKapcSVhchLs-LhAptuscpssEVlp+cLst-YcKscEVhtSlhD.p.H-.hltpGpRhhoacAhpGAhMIhFYRD-PRFppPaQLLptLMDIDoLhTKWRYNHVlhVcRMlGS.KpGTGGSSGYtYLRSTlSDRYKVFlDLFNLSTaL	.....................................................h..................h.Y.tYlthp.llt.Q.....o.....................sEhlFlh.HQ........s.ELah+.hhaEhpthht....ht..........t..t......h....t...............phltRh.hh.p.l.tt...h.tl.l.t.s..hos.pa...th...R.......Ls.uSG....FQShpaR.lE...............h...hG..............t..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	143	259	354
+4751	PF04820	Trp_halogenase		Tryptophan halogenase	Kerrison ND	anon	Pfam-B_2531 (release 7.6)	Family	Tryptophan halogenase catalyses the chlorination of tryptophan to form 7-chlorotryptophan.  This is the first step in the biosynthesis of pyrrolnitrin, an antibiotic with broad-spectrum anti-fungal activity. Tryptophan halogenase is NADH-dependent [1].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	454	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.49	0.70	-5.86	23	1611	2012-10-10 17:06:42	2003-04-07 12:59:11	9	14	630	30	502	3763	1761	272.60	18	79.12	CHANGED	+lVIlGGGTAGWhAAAtLu+th.st..hplTLlES-pIGslGVGE.uTlPsIpp.hpphLGl-Et-FhRtTpuTaKLGIpF.sWtp.............tuccYhHsFGs.hGtshthhsFap.....aWLchpttG.hssshssaslsshsApts+F.uss.ps......htslsYAaHhDAuLaAcaLR+hAcs+.GVpRlEGclssVphcs.sGaVsulphc-....Gchl-uDLFIDCSGFRGLLIppsLpsGacDWScaL.sDRAlAs.stsss....sssPYTc...uhAcpAGWpW+IPLQHRsGN.GaVaSScah.....s--cAhstLhsplsupshtpP.chlRFssGR.............R+psWs+NsVAlGLASGFlEPLESTuIHLlps....ulppLlplFPscshs.Ps.tlscaNcpsshEhEclRDFllLHYpsopRsDoPFWcpsR.phslP-sLpc+lcLFpsp...............uphhpttc-hFtpsSWhpVhhGQGlhPctacPLscshss	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..a.p....h.ptt..hs.....t.h.L.h.p.....u...t...G..sp.h..h.....t....t...h........t......................t.....................t......t...............h..............t....l....h.tp......................t...t...........h....p..s..c..h..hlDsoG.t...u...h.....l.........t..p.............h.....................................................p..........h..p...p..........h.................................t.......s.h....h..h......h....t........................s......t...........................h....s..........t..s...G.........W....W....I.....Ph.....t.......t................................................................................................................................................................................................................................................................................................................t..h.h............h.s.u..hhpP......h.....u....sh....................................h........................................................................................................................................................................................................................................................................................................t.......................................................................................................................................................................................................	1	157	306	427
+4752	PF01371	Trp_repressor		Trp repressor protein	Bateman A	anon	SCOP	Domain	This protein binds to tryptophan and represses transcription of the Trp operon.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.74	0.72	-4.07	19	1612	2012-10-04 14:01:12	2003-04-07 12:59:11	14	4	1574	49	242	835	143	86.80	39	83.21	CHANGED	pphptlh-hlhphtspcpp.thhp.lhT.sEhcuLupRlplsc.LLcppho.RcIppchGsShATIoRsupsLchusssapthLcphh	...........................phpphh-hlhshhsp-pph.hhp.lhTssEh..cuLupR.l.clsc.LL+.tp.ho.+-Icp-hGAuhATI.oRs..s.p.uLch.u.s.s.thcthL-chh............................	0	91	147	201
+4753	PF00290	Trp_syntA	trp_syntA; 	Tryptophan synthase alpha chain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.51	0.70	-5.85	18	4254	2012-10-03 05:58:16	2003-04-07 12:59:11	15	8	3921	94	1062	3690	2893	247.30	35	89.87	CHANGED	Fuphptpsp.suFVPFlsAGDPs..hEsolcllcsL.cuGADllELGlPFSDPlADGPsIQpAshRALsuGhThspsl-hlcchR.phsslPllLhsYaNPlhphGhEp....FhtpstcsGlcGlllsDLPhEEusslhphspctslshlhLluPsTs-pRlcplsctusGFlYlVSphGVTGscs.shssplpphlp+lKpho.shPlhlGFGISss-pspphs.tsADGVllGSAlVchlpp......phcptcpslpcltph...sp..hcsus+	............................................................................................................thptptc.sAh.ls.alssG.DPs..h-pohchlcsL........c....u....G............A.............DhlELGlPFSDPlADGPsIQp..AshRALs..s..G.s..........o..hppsh.c..hlpp....l.R...................p....p.....sph.P..llLMs...........Yh.N...l....hp....h..........Gl-p.....................F.hpcstcs.G.V.cGlllsDlP...h....E...E.u...s......h...t...t.t...s...p...c...t.s...l.s..hIhLssPso.sc...-Rlcplsptu.p...............G.F..lYh.lSh..sGV.TGs......ps....p....h.s.s.s..l.p.ph..ltc.l.+p.h........s......s......h.......PlhlGFGIussppsppht....t...sADGlI.lGSAlVch..lpp..........ph.p.p.........t.........................t..............................................	0	339	685	908
+4754	PF03222	Trp_Tyr_perm		Tryptophan/tyrosine permease family	Mifsud W	anon	Pfam-B_2873 (release 6.5)	Family	\N	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.24	0.70	-5.65	13	4713	2012-10-03 01:44:59	2003-04-07 12:59:11	8	5	1373	0	483	3542	123	382.30	25	94.07	CHANGED	+osphlGGshlIAGTsIGAGMLAlPlssAGshFhsohllLlhsWhhhhtSGLhlLElhpphts.....ssuhsTlucchLG+shpllsslshhFlhYhLhhAYIouuGuILppslsphhh.hshss+sssll.....FsllhusllhhuTp.slDphsplllhuhlluFslshshhlsclcsshLhs.....h..sthhshllsulPlhlsSFGFHusVPSLhpYhsps.l+cl++uIlIGoslsLllYllWplsshGslspspFhtlltpGuslssllpALtthhpSsshthslphFuhhAlsoSFlGVuLGLFDaluDlFKa.pcspsGRhchshlTFlP..................................PLlhulhaPpGFlhAluYAG.lusslassIlPslLsapuRpcpspts.a+VhGGshhllllllhGlllhlsp	..............................................................................h...........l.hGTsI..GAGh.L....hlP..l.s..h..u..u.s.G.h..h.h..s..h.h..h...l..lhs..a..s.hh.h........a.su.h....h.l..h.c..hs..p..sss.............................ssshsslsc..c..a...h....G...+......t......h.s.......h....l.h....s...h.h.......h....h......F.......s....l......a...s....l......s....h.u...Y.......h..........s......u.....s..........u....s......h...........l..........p..........p..........h..........h......s....p...........h....t........h.......s........h......s..........p....h....s...s..hh...........................h.s....l...l...h...u....h...l.....l...h........h....G.......pc.......h....l.......s.....+......h......s......s...h........l..l..h..s....h....l....h......h....h.l.....l....h.......h..h......h..L....l....s......p......h......p.........s...h....Lhs..................h....s..s...s......h...h......h...h.......l...h....h...s.l..P....l....h..l..h.S..F......u.a....p....s.....s....l..s....S....h.......s.........p....h........h......s.....p...c........hc.......+......l....p.....p....s......l......h...h.....u.....o.........h...l.s....L.l...h....a..l...h...a...h...h...u...s..h.h........s.l....s............s...p.............h...h...s..h...ht...p...s.......l..s.s...L..lp..s.h.up..h..hs.....s..........s.....h.....l.p.h..s.s.....s....l..hu.....h..l..A.....lsoS.....F.l......Gl.........h.L..G........l.h...-.......h....l....s....-......L.....h.............p.......h........s.......s....s..................t.........h........u........+...h.......p....o...........h..hl...s..F..l..s..............................................................s.h..h....h....s..l..h.a..P.s..u...h..l....hh.l..uh.uG.....h.............huh...l.h.h.llP.hh..h...hh......t......s....R.p........h.....................................................ap....s......hh.st.h.hh..hhhhhhh...........................................................................................................................................................................................................................................	0	100	201	347
+4755	PF01509	TruB_N		TruB family pseudouridylate synthase (N terminal domain)	Bateman A	anon	Pfam-B_792 (release 4.0)	Family	Members of this family are involved in modifying bases in RNA molecules.  They carry out the conversion of uracil bases to pseudouridine. This family includes TruB, a pseudouridylate synthase that specifically converts uracil 55 to pseudouridine in most tRNAs. This family also includes Cbf5p that modifies rRNA [2].	25.60	25.60	25.80	25.60	25.30	25.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.67	0.71	-4.05	171	5359	2009-01-15 18:05:59	2003-04-07 12:59:11	13	25	4803	48	1566	4094	1764	143.70	39	46.08	CHANGED	++...hh.....p...h+....KlGHsGTLDPhAoGlLslslGc.ATKlhpalh.sss.KpYpuphpLGhpTsTtDtpGpl..l...tp........h.tl.sppp....lcpsl.ppF.pG.pIpQlPPha.SAlKhsGc+LYchARpG..hpl-...hts.RplpIaplcl...lph..p...ts.......plphclpCS+GTYI	............................++lhpsc...KsGHsGTLDPhAoGlLslsl.Gc.ATK.hs.p.alh..sss..KpYpsplpLGtpTsTtD...........s..........pGpl.........l....pp...................s...p.h....s...t..cp.....................lp.p........sl.p..p.a.pG...pI.pQ.....lPP.haSAlK.hpG++hY-hARpG..........p..V..c.........p..ts..R.lsIaplph.....lp...h.....c..ts..........................phphcVpCSKGTYI....................................................	0	520	968	1305
+4756	PF01456	Mucin	Tryp_mucin; 	Mucin-like glycoprotein	Bateman A	anon	Prodom_3102 (release 99.1) & Pfam-B_3837 (Release 8.0)	Family	This family of trypanosomal proteins resemble vertebrate mucins. The protein consists of three regions. The N and C terminii are conserved between all members of the family, whereas the central region is not well conserved and contains a large number of threonine residues which can be glycosylated [1]. Indirect evidence suggested that these genes might encode the core protein of parasite mucins, glycoproteins that were proposed to be involved in the interaction with, and invasion of, mammalian host cells. This family contains an N-terminal signal peptide.	29.60	29.60	29.70	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.34	0.71	-4.41	6	1107	2009-09-12 22:44:45	2003-04-07 12:59:11	12	5	11	0	62	1096	1	150.00	37	94.82	CHANGED	Mh.....hpRlLC.lLhLAL.CCssVCsTApt..............................................tGQhssssspuusGpsppTTTTTTTpssTTTTTTT.................Tssss....sspsssTTsssTTTTTsspAPupssTTocAPTssssR..........SLGussWVssPLLLhVSAhshT..Ass	......................................................................................................................Mh...pCRLLCALLVLAL...C.C.C..s..sVC.s....s..tpt....................................................................................................................................................................................................................t..........t....t............t.....s......t.....t.....s....ps........p.....t.....p........s...s..s..s..s....s.....p..s.s...s.s...s.ps..sp................................................................................t.t.t........s.......t....t..p....s...s.....p...s.s...s..s.s.s......s......o........T....T....T.T.T..s..sp......A.P....s...........s.....T.T.o.cAP....o.s..o.......TT.+A.P........Stl.RchDGSLuSSAW.....VCAPLlLAsSALAhT..sl..........................................................................................	0	3	3	62
+4757	PF00913	Trypan_glycop		Trypanosome variant surface glycoprotein (A-type)	Bateman A	anon	Pfam-B_1351 (release 3.0) & Pfam-B_2618 (release 8.0)	Domain	The trypanosome parasite expresses these proteins to evade the immune response. This family includes a variety of surface proteins such as Trypanosoma brucei VSGs such as expression site associated gene (ESAG) 6 and 7 [3].	22.10	22.10	22.10	22.20	21.90	22.00	hmmbuild  --amino -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.08	0.70	-5.55	63	493	2009-01-15 18:05:59	2003-04-07 12:59:11	14	4	12	4	163	485	0	305.80	17	79.35	CHANGED	hshhllhshh......sppssussptulpts.sWpslCplop-Lc.plsutshpphpshhsthpphpptth+hplash....tpsssppspthsslsuhh....ppstpshpshhssthppulsAsusuuhltG+IcEalsl...hspspsuuss....CLssssssssssss.........hthstspsphphsssssp...stssstlsssGapshh...........sssssptssssppCpLh.....tsssssGhspsss.........tssslphu.uGhlsls.....tsssthshtthtshttttptttt.hhthhtt..........tptspssssthpssssshpsssphppslpphht.....tptttptpphtptlpphhtsspspthpt....hhttht.p.plstthh....stsptspLs.cIssh.ppLtplLthhptptt	.................................................................................h....hhhhh...........h...ts...t...t.t..u.lttp.shptlCsloptL+.t..............lsthst....p....pht.......t....h...t.p.ph....p..ph.p.....t....h..p..h..p....lhhh.........htsst..pss........ptht..h......Lhtth......hpthtphppphpph........t....ptuhtAuu....tA........uhuAGRl-Ealtl...........Fup..ut...........s....susph............Clusssssssptsp....................thp.s.tth.hppspps........htttpshss..tshpsl............................sspshts.s.ss....pss...CsLh.......pssssG..hhtsss..................hppshhau..uGlhshs...............t.t..........................................................................................................................................................................................................tt.........................................................................................................................................	0	121	163	163
+4758	PF03249	TSA		Type specific antigen	Bateman A	anon	Pfam-B_3060 (release 6.5)	Family	There are several antigenic variants in Rickettsia tsutsugamushi, and a type-specific antigen (TSA) of 56-kilodaltons located on the rickettsial surface is responsible for the variation [1,2]. TSA proteins are probably integral membrane proteins.	19.80	19.80	20.30	30.10	19.50	19.30	hmmbuild  --amino -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.73	0.70	-5.96	8	365	2012-10-03 17:14:37	2003-04-07 12:59:11	8	1	7	0	1	363	0	374.30	72	96.08	CHANGED	IELGDEGGLECGPYAKVGVVGGMITGVESsRLDsADu-GKKHLPLTTuhPFGGTLAAGMTIAPGFRAELGVMYLpNIoAEVEsGK..............ssucADosssTD...uPIhKR..KLTPPQPTIMPISIADRDhGVDlsNlPQAQstts..QlNDs..RuAcRIAWLKsYAGIDYhVKDPNNP.GsMhlNPVLLNIPQGNP...uNssptAhQPsDhsILDH-QWRalVVGlsALSNANKPSlSPVKVLSDKIoQIYsDIKPFAcIAGI-VP-ssLPNSASVEQIQNKMQELN-lLEELRESFDGYI.GNAFAsQIQLNFhIPQtA..QQQQGQG.QQQQAQATAQEAsAAAAVRlLNG..N-QIlQLYKDLVKLQRHAGIKKAMEKLAAQ.t.DutspGuGDsKKKQG...ASEcSccsutu........KETEFDLSMIVGQVKLYADLhTTESFSIYAGVGAGLAYTpGKIDsKDIKAHTGMVASGALGVAINAAEGVYVDIEGGYMHSFSKIEEKYSVNALMASlGVRYNF	........IELG-EG..GLECGPYuKVGlVGGMITGsESsRLDsADs-GKK+LsLTTuhPFGGTLAAGMTIA.GFRAELGVMYLpNIoA....pVE...GKsKs.....................DStGcsKADSu.sGsD.....API.RK.R.hKLTPPQPTIMPISIADRDhGlDlsNlsQAtAtts....Q..LNsE...QRAAtRIAWLKNhAGIDYhVpDPNNP..GshVlNPlLLNIPQGsP...uNs....pRspQPsshsIhs..H-QWRaLVVGlsALS.NANKPSsoPVKVLSDKIopIYSDI+.FAcIAsI-VP-ssLPNSASVEQIQsKhpELsphLE-lR-SF-Ghl.sNAFssQIQLNF.hP.tt....QtQ.GQ..QQQQ..uQsTAQ-AsAAAAVRhLNs..NpQI.QLY+DLVKLpRHAGl+KAMEpLAsQ..........D.stt.............ps..tspscppp....ss.p.pp.....t.t..........+.EsEFD...LSMl..VGQVKL..YADlhhTEShSIYuGlGAGlAaT.GKIDshDlK.pTGMVsS...............................................................................	1	0	1	1
+4759	PF01166	TSC22		TSC-22/dip/bun family	Finn RD, Bateman A	anon	Prosite	Family	\N	25.00	25.00	25.10	25.90	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.89	0.72	-4.01	10	339	2009-09-11 08:14:02	2003-04-07 12:59:11	13	4	87	2	161	275	0	59.20	65	15.71	CHANGED	MDLVKoHLMYAVREEVEVLKEpI+ELh-+NupLEpENsLLKsLuoPEQLsphpu..plpsss	.................MDLVKSHLMYAVREEVEVLKEQI+ELhE+NSpLEpENsLLKoLASPEQLuQhpu..pht..ss..................	0	26	42	96
+4760	PF04668	Tsg		Twisted gastrulation (Tsg) protein conserved region	Waterfield DI, Finn RD	anon	Pfam-B_4556 (release 7.5)	Family	Tsg was identified in Drosophila as being required to specify the dorsal-most structures in the embryo, for example amnioserosa. Biochemical experiments have revealed three key properties of Tsg: it can synergistically inhibit Dpp/BMP action in both Drosophila and vertebrates by forming a tripartite complete between itself, SOG/chordin and a BMP ligand; Tsg seems to enhance the Tld/BMP-1-mediated cleavage rate of SOG/chordin and may change the preference of site utilisation; Tsg can promote the dissociation of chordin cysteine-rich-containing fragments from the ligand to inhibit BMP signalling [1,2].  	25.00	25.00	29.60	27.40	18.40	24.10	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.06	0.71	-3.95	11	135	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	83	0	82	122	0	122.90	45	58.17	CHANGED	psphop+SplE-L.-ulPsLFcAlTu..EsDut.hpWslhoFPl....h..hsptpshsphL.s.ss.pts..htsPsssloss........CTVlYhspChShp+C+QoCESMGASpYRWFHsGCCECVGspClsYGspEoRCppC..	........................................s.s.opKSpVE-l..-s..lP...uLFcALT...Es..Dst...hpWslhoFPl....s.thsphc.s..hspah.ph.s...p...p.....hp......h.s.......h........sss.hpss.............CTVlYhcpChShppC+.oCcSMGASpYR.............WFHsuCCEClGspClsYGspps+ChpC..............	0	19	25	55
+4761	PF04705	TSNR_N		Thiostrepton-resistance methylase, N terminus	Kerrison ND	anon	DOMO:DM04814;	Family	This region is found in some members of the SpoU-type rRNA methylase family (Pfam:PF00588).	27.10	27.10	27.70	93.80	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.38	0.71	-4.29	3	6	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	6	6	1	11	0	114.70	52	41.82	CHANGED	MTELDlIsNsSDPAVQRIIDVTKHSRSsIKTTLIEDlEPLMcSIRAGVEFIEVYGSDooPFPu-LLDLCc+RsIPVRLIDuSIVNQLFKuERKAKVFGIARVPRPARFADIASRu	.MsphDlIsstSDPAVQRIIDVTK+SRSslKTsLIEDsEPLscuIpAGVEFIEVYGs-uoPlsscLLshCcpRsIPVRLlssulsNpLFKuERKsKsFGIARVPRPu+FuDlAsR.s.	0	0	1	1
+4762	PF00090	TSP_1	tsp_1; 	Thrombospondin type 1 domain	Sonnhammer ELL	anon	Published_alignment	Family	\N	21.60	12.00	21.60	12.00	21.50	11.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.19	0.72	-3.85	31	18854	2009-09-12 10:45:09	2003-04-07 12:59:11	14	787	233	25	10470	16743	573	50.30	28	19.16	CHANGED	o.WspWSsCSV.TCG.pGhphRpRhsst......sssCstsspp......schC.phcpC	..............h.u.sW....o.........t....C.......S......t.....o.......C.........G.....s.......G........h.......p.....p.....R.p....+...p..C.....t..s....................s......s...p..............C....t......s......t..t..t....................hp.....C..p.t.C........................................................	1	2752	3498	6471
+4763	PF02412	TSP_3	tsp_3;	Thrombospondin type 3 repeat	Bateman A	anon	SwissProt & Pfam-B_2972 (Release 8.0)	Repeat	The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats [1]. The repeat lacks defined secondary structure [2].	25.00	13.60	25.00	13.60	24.80	13.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.18	0.72	-4.48	11	4235	2009-09-16 13:31:17	2003-04-07 12:59:11	13	198	363	36	1963	3922	3104	30.90	43	18.51	CHANGED	cDuDuDGlGDAC....-pDhDsDGl.shhDNCPhsuNssQ	.....................................C................p..t...D...t...D..s..D.G.l..D...p......p.......DsCPhsss.t..........	0	606	831	1367
+4764	PF03073	TspO_MBR		TspO/MBR family	Mifsud W	anon	Pfam-B_1882 (release 6.4)	Family	Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light [1]. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates [3]. In [2], the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.	20.70	20.70	21.20	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.98	0.71	-4.68	148	1274	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	1043	0	537	1142	1226	141.80	27	85.38	CHANGED	llhlslshssuhhuuhhoss........ss..W.YpsLpKPsasPPs.alFsslWTlLYhhhuluuahlapth.........tpptsphslslaslQLsLNhhWSslFFuh+......phthAhl.llhLhlsllhshhtahp..lsphA.uhLllPYlhWlsFAshLNhs.lhtL	...............................................h.hhhhhshhhuhhuu....h....h....s......t.......tp....W...Yt..s.Lp+P...s.asP...Ps..hlFs.lWsl..L.Y.h.hh.u.l.uuahlapp.........................ttpttphsltl.a.sl.QL.hlNhh..Wo..lF....Fsh+......phhhAh.ltlllLhhh.lhhh.....h.......hha.hp.......lsp...h..A...uh..L....h....l.....P...............YlhWlsFAshLNhslhh..................................................	0	183	330	441
+4765	PF02956	TT_ORF1		TT viral orf 1	Bateman A	anon	Pfam-B_1612 (release 6.4)	Family	TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.	19.60	19.60	20.10	19.60	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	525	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.85	0.70	-6.05	58	3965	2012-10-04 01:49:40	2003-04-07 12:59:11	9	3	72	0	0	2670	1	111.10	45	87.44	CHANGED	Msa.WWhRR....R+...WhhphhR...................RhRRhhRRh+RRhps..RR..RRR.hhthp+....RphhRRRp....hRR++KKl.hlpQWQPsslR+CpIcGhhPlllsGc...sptspNYshcp--hss.....t..........PaGGGaosppFoLchLY--ap+tpNhWTtSNppLDLsRYhGsphpFYRHspsDFIVpasppPPFphschotsshHPuhlhhsK+KhllPShpT+PpG+thl+l+IpPP+hhpsKWYhQpDlCsssLlsltuoAsshpaPasusposs.sloFts.Lss.hYppshhh............................sstppt.t.h.t.laps........................thYpohts.tpl.p.httssptpp....ttp....t................................sss.Yst..ap.........................................................tlpYcsGhaSshaLssh+h.shp.h..............ssat-lpYN.PhpD+GpGNplWh.p.hoKtsspa...spspschllpslPLWsshaG..Yh-alpppt.tspshhtsthlslhsPYTpP...hstss..sshual.hDhsFspGKhPts.sshlshhhct+W.YPphhaQppsls........slspsGPa..sY.+s-ppss.pLs..hpYcFpFpWGGs	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s..Kps..Y...sKspSKCLltsLPLWAusYG..YhEaCuKsT..GDs..N..IchNsRhl.IRSPaTsPQL.ls..H..ss..P.+GaVPYS..........................................................................................................h.........................................................................................................................................................	2	0	0	0
+4766	PF02957	TT_ORF2		TT viral ORF2	Bateman A, Mifsud W	anon	Pfam-B_1489 (release 6.4) & Pfam-B_4693 (release 7.6)	Domain	TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals, and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF2 is a 150 residue protein. This family also includes the VP2 protein from the chicken anaemia virus which is a gyrovirus. Gyroviruses are small circular single stranded viruses. The proteins contain a set of conserved cysteine and histidine residues suggesting a zinc binding domain.	21.10	21.10	21.10	21.10	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.77	0.71	-3.41	17	774	2009-09-11 23:42:44	2003-04-07 12:59:11	10	4	129	0	1	695	0	100.80	26	68.28	CHANGED	apPs...hastpthptpWhsshhpoHshhCGCscslcH.......hhp..........................hh+ptssL.ht.pt.tpht.h..sssp-uss.......tssG-s.t..sh......spuDlDhL.hAt-hs-p	....................pss...hhs.ptppphWhpsshpoHushCuCssshtH................Lpph...t...th.t....................s.s.t.s....t.t......h+h..........h.........................................................s.s.t..t...tt.................................t..............................................................t.t...p...........s....................................................................	0	0	1	1
+4767	PF03542	Tuberin		Tuberin	Griffiths-Jones SR	anon	PRINTS	Family	Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterised by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. The TSC2 gene codes for tuberin and interacts with hamartin Pfam:PF04388 , containing two coiled-coil regions, which have been shown to mediate binding to tuberin. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking [1].	19.50	19.50	19.60	21.20	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.15	0.70	-5.39	5	261	2009-01-15 18:05:59	2003-04-07 12:59:11	11	12	189	0	169	279	0	274.60	30	18.27	CHANGED	lV+SEsElEDIlsAVDGLl+VFpVKLYRLPusHAl+VYslLluHLEtHYc+PalLtplSlIRY+IF-WhLpARANuSaHIGYP-uE..pss+VRFSsYLGl-uP...............ppupuosphsLs.hussptsspssslhPsosLTsISI+RuCpVIVpCLKcEpDWpVlQLVLoELPcVLQNKALIQGND..lDuLAsTLhKMhsD.hplE+L.pusstusspoDlHsLVLPALoSLAoYHpaLDsspQ+sIIsuLcpGLIoRpASlCIsoLTILlLEMP-sLhs+LPDLLlcLSKMSuTshlAlPVLEFLSTLlHLPpHLauNFssppYMsVFAISLPYTNPaRYDHYTVSLAHHVIAuWFlKCRLPh	.............................................................................................................................................................................................s..........................................................................................................................................................................................................................................................t....h....p...s.......hl..shshhhpsllphL.c.p-sDWcVhphVLs+Lstp......Lp.+sLhh...s...ss...plcpLpssLsph.l....p..................s...h..h..................c...ph.....tt..ss..p..s.hp+sDlthsl.h.sLosLloYHphh.s..+sc..........pc....-hVtsh..pG...l..h..p..........c..........s...A..pt..C..l...hALolCshEh.P..sl....hKtLssll.s+h.o+l.s..oss.hAl...lLEFLusLuRLP.pLYtNFtt-patpVFuIsl.Y...............h....p.................st+....................t.................................................................	0	54	81	133
+4768	PF00091	Tubulin	tubulin; 	Tubulin/FtsZ family, GTPase domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.38	0.70	-4.52	94	20546	2012-10-03 12:11:42	2003-04-07 12:59:11	20	44	10719	170	3790	14692	2809	152.80	36	51.77	CHANGED	pIhslslGsuGsphssphhc.................................................................................psh.s.schlhlsTDspslsp.hpsspp.....lhhspphhpGh..G..AGus.t.hGpp.................................stccshcpI.cctl............c.s.hchhhlssuhGGGTGoGhusllschh+-h.................................s........t.lsluhsshPh.....ph.Eshhc.hsAhhulppL.hcpsDsllllsNspLhc........ls..............spphslp...................ssapp	...............................................................................................................................................phh.t.thhp.....................................................................................................................................................................sshhs...sc.h.l.hlsh.-.s..t..s...h...........ct....s.......+........s...ush.................l...hs.........cp..h....s....h.....G..........G................AGsN.......t....hGc.................................................................................................hhc.s.h-...l...pp..h...................................p...s.h.....p................h..h..lh.tuhG.G.G..TGs.....Ghu.sllh....ph.hp.p..................................................t......h..hhhsh.s.s..h..P.............ph..-s.h...h..c.......h...........t..u.....uh..ppL......hc......p...........sD.....p.....h...hhlsN..pt.lhc..................ls......cp.hth...sa..t....................................................................................	0	1325	2173	3053
+4769	PF00418	Tubulin-binding	tubulin-binding; 	Tau and MAP protein, tubulin-binding repeat	Finn RD	anon	Prosite	Family	This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilise microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau (Swiss:P10636) is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif [1].	21.60	21.60	22.50	21.70	20.70	21.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.32	0.72	-4.26	12	1318	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	98	0	474	1352	0	30.90	51	14.99	CHANGED	Vplhsptl.Dlp.pVpSKsGSp-NIKHpPGGGp	..........VpI.spKl.Dhp..pVpSKsGSh-NI+HpP..G..GGp...	0	102	146	270
+4770	PF01021	TYA		TYA transposon protein	Bateman A	anon	Pfam-B_90 (release 3.0)	Family	Ty are yeast transposons.\	\	  A 5.7kb transcript codes for p3 a fusion protein of TYA and TYB.  The TYA protein is analogous to the gag protein of retroviruses. TYA a is cleaved to form 46kd protein which can form mature virion like particles [1].	25.00	25.00	26.50	26.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.43	0.72	-3.79	4	183	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	13	0	119	181	0	91.70	76	12.65	CHANGED	ACASVTSKEVpTNQDPLDVSASKhpEa-+sSTKANSQQpTTPsSSAVPENtHHASPQsAQsP.PQNGPYpQQsMMTsNQANsSGWuhYG+PSMMPYoP	AhASVTSKEVpoNQDPLsVSASpl.EaD+sSTKsNSQQpTTPuoSAVPEN.HHsSPQPASVPPPQNG.Y.QpsMMT.NQA.sSsWuaYt+PSMhsYo.........................	0	88	88	88
+4771	PF03251	Tymo_45kd_70kd		Tymovirus 45/70Kd protein	Bateman A	anon	Pfam-B_3418 (release 6.5)	Family	Tymoviruses are single stranded RNA viruses.  This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase [1].	25.00	25.00	192.80	192.50	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	463	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.37	0.70	-5.80	13	23	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	0	0	23	0	464.50	32	74.92	CHANGED	MSNGhPsSsRpshlcpoQtplhpssochtssssstLssslPLcpscGosohsphlRcPsl+hRhpssPPssPQssRs.soLpPL-hstpsuhhscVHETlcVppsstppspL.pssQLPupspRhpSlPpHLphsupttsRlHARRuDVL.uhosstslpslspsssslLQspsusRt.LHRsLshPpsLHLps.RppsuL+sR+ospRpLQsAsppspLAEsthH..s.spPlpppsGILGPsPLhscspR..........sPpsshppssss..........................slLPsPphspuupuaLPsPTossPs+sspulpRslHLHsSpssosclRPpRlRssulQQspspLGHspuLGQSsNLRusppspPo+pplpLhPhssspspsl.hssh........sP.hppp.Sh....hP+Psss.sshstsssp...hpsplPssh.s.......ssphsssss......suhssssssssssssss...............Ps	MSNGhPsSsRRshlapSQRplsposSchpspssstLsssLPLspscGosuhsphlRHPslRhtppPsPPppPQssRs.soLpPLthPtppShhpcVHEThpVppsstppscL.pspQLPspspRp+SlPpHlppsu..pptp+lHARRsDVL.uhssptslpshspsssslLQspsuoRt.LHRslsLPcsLHLps.tsposL+sRco.pRpLQsAsppPhLAcsphH.....s.s.slpcpsGILGPsPLsscspR.s..............sPpsthspssss.............................h.s.t.slLPss+h.poSpuHLPssTsssPspsspuLpRPlHLHpSssposchRPpRlRpculpQscspLGH.psLGQSusLRsscpssPs+ptLpL.spPstpspslspssL........sP.httttSh.h..hPpPsshhsshshsosp...hphplPpsh.s.......spth.ssss......sphshtsshpss..sss.h.....ssss..s................................	0	0	0	0
+4772	PF00983	Tymo_coat		Tymovirus coat protein	Finn RD, Bateman A	anon	Pfam-B_1429 (release 2.1)	Domain	\N	19.00	19.00	20.10	26.20	17.90	17.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.92	0.71	-4.56	9	153	2012-10-04 01:49:40	2003-04-07 12:59:11	13	4	51	27	0	158	0	167.60	34	41.30	CHANGED	ps.QssIsssuopLP.ssGppsPoIl.PFQhpssohGsp-susplolAotssluplTohYRHApLspLpAsIpPouhAsupPsTVsLsWVPsNSoATsupILs..lYGGQpFslGGuIsospsIpVPssLssVNPhIKDSVpYTDoPKLLlYSsAsssss..sssTsolpIpGplp	....................h..............s...s.sssslslPFQh.p.shsh.Gst.s.s.t.s.ols.luussslopLsusYRHApLhpLcAhltPshsuhupPholslVWssAs.ssssssplLp..sYGGpphslGGslshsushpVPAsLsplNPhIKsSVsYsDTP+L.hh.sssssssus.....sssh..shlhlpGhl.............................	1	0	0	0
+4773	PF00264	Tyrosinase	tyrosinase; 	Common central domain of tyrosinase	Sonnhammer ELL, Griffiths-Jones SR	anon	Prosite	Domain	This family also contains polyphenol oxidases and some  hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.	22.30	22.30	22.30	22.30	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.22	0.70	-4.19	127	3739	2012-10-01 19:27:11	2003-04-07 12:59:11	15	75	1610	58	1016	3969	31	141.50	35	41.98	CHANGED	tspapphs.................uhHt................................................thshs.hHs..ss....hFhsWHRhYlhhaE.....ptLpp.................ts..................sssthtlPYWDWs..........................sps..ht.ssslhs....ss.h.uh....................................t.h...hss...Fs..shhsph.......................................p.cshp+sh..........................ssttspthsstpp........................ltphlht..................................sshpsFpshh...ps.................................thHsssHh.hlG......................................Gp...............h....ushhsushDPlFalHHuplDRlathWQph	..........................................................................................................................................................................................h.psYDhFV................hlHhhsscss.......................................htss.sh.pshch.uHp...us.......uFlPWH.RhaL..L.haE.....+plp+....................ls.........................sspsFslP..a..Ws.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	335	609	862
+4774	PF03064	U79_P34		HSV U79 / HCMV P34	Griffiths-Jones SR	anon	Pfam-B_2985 (release 6.4)	Family	This family represents herpes virus protein U79 and  cytomegalovirus early phosphoprotein P34 (UL112).	23.20	23.20	23.20	24.60	22.50	23.10	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.82	0.70	-4.86	5	51	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	24	0	1	53	2	236.80	47	48.69	CHANGED	RcYGTF-NVscsYcQIVocolcLRRacF-oGClI-FlusSG+CEsausGWIS.MIhWTSETsS......tGSLTlDIssD-GppKTY..pARGtILCSKSITSISQso...EG+-+lLTlspENGKLQlTaVTlsKsu+-s-l+slG.DsKstcpFEKECpAs-RKKp...DD-++K+SuKQKEKRRsED..cK+cEDc+KKpE.......c++psDs-Kpsspc-cu.sttpp..pph.........D.....psscEKRQK.aH-s..-RcLEcQScE	.............R+YaTFsNssRlLHQsVspoFDVRQFsFDoARlVsCl-G-G+s.phsKGWLC.ATIMQpu-uuuuu......pstQGhMSlDITuDspLpcph..FsRGuIVhNKoVSSVVGss....ssscuuLLThluEsGsLQVTaVcHhh.psHs...psusssu.....usGsAusAu..AVs.s.....oShGuS.......uGspcGsus.ppppRRRpc..........ppH--cR+Kppp.....................pttsu..GuuGuuGGG.s.GuGSGGppu..sotp....thLc-...........st..pRQK.......ERc..Pspp.........................................................	0	0	0	1
+4775	PF02134	UBACT	UBACT_repeat;	Repeat in ubiquitin-activating (UBA) protein	Mian N, Bateman A	anon	IPR000127	Family	\N	20.50	20.50	20.70	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.08	0.72	-4.40	128	1697	2009-01-15 18:05:59	2003-04-07 12:59:11	16	51	346	44	1116	1656	35	65.80	34	11.72	CHANGED	pF-cDDsss..lcalhusuNlRAppasI..s...h...............shhps+tls.upIIPAlAoTsAlluuhs..shEhhKllpsp	..............F-pDDssp....lcFlhuuuNLRApsasIp.s...t...............sp.tps+.t......ls..spI.I.PAlAoT.sAhlsuls..shEhhKlht..t................	1	397	620	910
+4776	PF01977	UbiD	DUF117; UPF0096; 	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has been characterised as 3-octaprenyl-4- hydroxybenzoate carboxy-lyase enzymes [1]. This enzyme catalyses the third reaction in ubiquinone biosynthesis. For optimal activity the carboxy-lase was shown to require Mn2+ [1].	19.80	19.80	20.40	19.80	19.40	19.70	hmmbuild  -o /dev/null HMM SEED	407	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.04	0.70	-6.02	155	3152	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	2165	3	810	2356	887	380.40	36	83.80	CHANGED	lptL.ccpG..p....Lhclcp.Vs.spL....Elutlsc+........hhp........t..tss....AlLFcsl...cGh.........hsll.sNla...u.op........cRlshsL.Gh.........phpplsppltphh.p.................ht.hsh.hphh............pusspcshh..tpphD..L..pc.LPlhppaspDGG......alTh...................uhVloc..sP.cs.......NlGhYRhQ.lhs.....c.pcluh+hh..t+css.phap...ch....pcpG...........................c..phPVAlslGs-PshhhuAs.hP...lP...slsEhthAGhLp....Gpslcllcst...sssL.VPAsAElVlEGhls...s........p.ht....EGPFGDasGY.Ys..scp....hPVhcVpslptRc..c.PIa.ss.lsGpPs..tEcphlutsspchhl...shlptthP.p....lh-lhhs.tusha..hsllsIccpa........sGc.........u+plhhuhaustt.h....hsKhlllV....D.cDl-lpDhppVhWAlso.....Rhcss+.....Dlhllsss.s..ss	.............................................................................................................................................................................phL.-ppG..pLh+I.st.Vs.sphElst..l.scc.........sh+...................s..tGP....ALLF-Ns...p.Ghs........hPV.l.sNla...G.o........................cRlAhuh..G.................shpplsc...h..l.shhhc....................................h....sh..phl............................psusspp..lh..p....u..-c..l.s......L.............tc..lPl.ps.ast.Duu....................shlTh....ulslo.+..sPpc.........tppNlG..IYR.Q..lhu.....+.s+lhh....+als....p+ssA.hc.hp..ch....t.c.....G............................................c..t.hPlulslGsDPshhluAssP........l.P.........sl...oEh.thAGhLR....Gp.hclsps......s...s.s...lpVPAsuEllLEGhlp.................s....................tcht...E.......G.......P......a...G.....DaTGY....Ys..tscp......hPVhplpploh.Rc...c..sI.apoT.hs.G+..P...s...sE.sshLussh.s......clhl...sl.Lp..p..phP..E....lhD.hahP..p.G.ssa...hAlloh.+K.pY..........sGa.........A+pVhhusaohhpth....asKhlIls..................D....-D...l.s.scDhscVlWAlso.....RhcPsRDhlhlpsssh................................................	0	231	482	658
+4777	PF01209	Ubie_methyltran		ubiE/COQ5 methyltransferase family	Finn RD, Bateman A	anon	Prosite	Family	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.45	0.70	-5.25	5	4079	2012-10-10 17:06:42	2003-04-07 12:59:11	13	9	3618	4	1229	27075	9319	227.00	38	91.29	CHANGED	pTslKEp+...VpcVFcSVAo+YDhMNDVlSFGIHRLWKc.FTh+psus+cGs.....shLDVAGGTGDlTFcLo-ulGsoG.............KVlllDINEsMLKhGccKl+-pGhh....sIEaLpuNAEcLPF-D.soFDslTISFGLRNsoDh.KuL+EhaRVLKPGGpllCLEFS+PphPlhcpAY-hYuKtVMPhhG+llAc-h-SYpYLsESIRcFPDQ-TLcuMhc-AGFcuVcYcsLTGGlsAlHhGhK	............................................................................................................................tp....Ktpc...VtplF.c.s..l..A.s.+....Y..D....l.....h.....N......c......l....h....S.........h.....G.....h......H.....+....h.......W...+........+......h...s....h.....p.........t....h.........s......s.....c.........G.p...................................p.l..L.....Dl..A...u....G....T....G........D...l....s....h....t....h....u....c...t....s...s..t....p..u......................................................c.V.s..h..s....D.....h......s........p.......s.......M.......L......p......l.....G......+......c.........+.........h....h.........p.....h....s..h...........................s..l..p......a......l.........p...............u........s...............A......p........p........L.............P.................F.................s..........D.......s.........o...........F..........D............s......l........T...........I.......u............F......G............L...........R.............N............V...........s.......-...........h............p.............p...........A......L........c....E........h....h.....R.....V.......L..K....P...G.....G.+..l........l...........l........L.........E.....F.........S.......p.....P......p.......h...............s........h....p....p.....h........Y..........c......h......Y..........h......p.............l.....l...P......h.....h...G...p......l.......l...u...p.....s...t.......c..u......Y...p.....Y.......L...s..E.....S.....I...c.....t.......a.P.....s...p....c..p......L.....t......th...h.p...c.AG.F............p.....p..l......p........a......p......s.ho.uGlsAlHhGhK.........................................................................................................................................	0	414	798	1059
+4778	PF03981	Ubiq_cyt_C_chap		Ubiquinol-cytochrome C chaperone 	Finn RD	anon	Pfam-B_5272 (release 7.2)	Family	\N	21.50	21.50	21.50	22.20	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.60	0.71	-4.33	63	1111	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	985	0	313	697	717	153.30	26	61.36	CHANGED	pphsls-ThsucaphhsLHhallhhR.................l+sts...ttu.....ptlsQplh-thhpDh-ppl+chuls-hsl...sKph+ph....sptahGthhAYDpulst...sstsLusALh.RNlhpst................shp...phttlssYltpthttLsshsspslhsuth....ta	..................................................................chp..phlsuchphhshcshhshlR..................................LKu-t........hus.....hplpQpLl-pahccs.pchc.c..t..p..h.p-hht........stplpcL....pphh.hhht.sh..hAhss...........hsspL..sthLtpphhhuh........................................................................scshh.....chsuLsu.Vtsslss.lcsluusuhtssh...ssh.....................................................	0	109	180	253
+4779	PF02271	UCR_14kD		Ubiquinol-cytochrome C reductase complex 14kD subunit	Mian N, Bateman A	anon	Pfam-B_4192 (release 5.2)	Family	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [1]. This Pfam family represents the 14kD (or VI) subunit of the complex which is not directly involved in electron transfer, but has a role in assembly of the complex [2].	20.70	20.70	21.20	29.60	20.60	19.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.12	0.72	-4.27	25	388	2009-01-15 18:05:59	2003-04-07 12:59:11	11	4	303	52	242	377	2	101.50	37	76.61	CHANGED	lhppPtLs+lhhPlAphahN..huGYRphGL+hDDLlsE...EssslpcAL+RLPccEsYsRsaRItRAtQLSloHplLP+ccWTKsEEDssYLpPYlt-lcpEtpE+p-	..........................h..........hh.s.ltpha.hs......suG..ap..ch.GL+...........hDDll.E..........s.sVpcAl+RLP...cc....h.sRsaRlpRAhp....LShp+plLP+-p.WsK.-...-D..h......Y...LpP...hlp-lppEppE+p......................	0	77	127	196
+4780	PF02320	UCR_hinge		Ubiquinol-cytochrome C reductase hinge protein	Mian N, Bateman A	anon	Pfam-B_11849 (release 5.2)	Family	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [1]. This Pfam family represents the 'hinge' protein of the complex which is thought to mediate formation of the cytochrome c1 and cytochrome c complex.	22.00	22.00	22.20	24.20	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.41	0.72	-4.03	24	379	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	288	52	237	373	5	64.70	37	55.86	CHANGED	VDPhppLcEcCttpscCsphhpcappCscRVpucsp........scEsCspEhFDhhHClD+CVA..KLFspLK	................DPhpplcEcCtpptcC..sphhc+a-pCs-RVpscsp...............scEcCsEEhF-hhHshDcCsA..KLFppLK..................	0	78	131	193
+4781	PF02921	UCR_TM		Ubiquinol cytochrome reductase transmembrane region	Griffiths-Jones SR	anon	ref [1]	Family	Each subunit of the cytochrome bc1 complex provides a single helix (this family) to make up the transmembrane region of the complex.	19.90	19.90	20.20	20.00	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.09	0.72	-3.74	30	409	2009-01-15 18:05:59	2003-04-07 12:59:11	9	10	305	58	228	405	5	61.80	36	24.87	CHANGED	upTch..phPDFo......sYcccp.........css-sp+uFoYhhl.GuhulhsAsuAKssVpsFlSoMSAS....AD	....................psh..phPDFs......pYccpp..............pusss+....+uFoYhhs.Gu.....sulssAhuAKssVppFlsoMSASAD.....	1	79	127	188
+4782	PF02939	UcrQ		UcrQ family	Bateman A	anon	PSI-blast P13271	Family	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex [1]. This family represents the  9.5 kDa subunit of the complex. 	25.20	25.20	26.70	26.40	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.49	0.72	-4.16	7	257	2012-10-01 20:10:32	2003-04-07 12:59:11	11	4	223	52	177	256	0	78.40	35	78.44	CHANGED	hhtahshsK.+GIhoYulSPapQ+shsGhFcpul.NsFR.RspophLYhs.PhshhYhlashupcpNphL.pKsstc.hpc	..........................hht.hhsh.s..+..+tlhoYuLSPacQ+shsGhhppul.Ns.aR.Rh+.sphhhVsP...PhlhsYhlhsWupccpchhppKsstt..t...................	0	51	86	144
+4783	PF00984	UDPG_MGDP_dh		UDP-glucose/GDP-mannose dehydrogenase family, central domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1105 (release 3.0)	Domain	The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate [2].	20.60	20.60	20.90	21.50	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.83	0.72	-3.77	26	6968	2012-10-02 19:36:47	2003-04-07 12:59:11	14	24	3680	103	1988	5681	4792	94.60	34	22.22	CHANGED	lpoAEhlKhssNsahAs+IoFhNElupIs-plGsDlpcVhculuhDsRls....ahpsG.GaGGuChs+DshsLsttupphshssp..hhppllpsNpsp	...............psAEhsKlhsNsahAh+IuahNElu.p.ls-p.............h..G..l...slpclhcussh....D.sR..ls...............hh.pP.G.....G.a.GGpClPKDshtLl.t.p.s.p.p...sh..p.....llpthhpsN...t...............................	0	678	1317	1697
+4784	PF03720	UDPG_MGDP_dh_C		UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1105 (release 3.0)	Domain	The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate [2].	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.49	0.72	-3.89	161	6858	2009-01-15 18:05:59	2003-04-07 12:59:11	10	20	3675	103	1921	5532	3768	98.00	25	23.17	CHANGED	ulLGluFK..ssocDhR-SPulsllptLhpp...Gu.....p.lpsaDP..hstptthth.........................................tlph..htsh..tcslpssDslllhT.-a.spFcp.h...s.tthhphh....pss.llhDsR..slh.ct	....................hlhGLsFK..ss..oDD..h.R-.Ssuhslhcp..Ltp.t..Gs....................c..Vh.laDP..hspppthth................................................................................................slph.h.p.sh...tpsh.p..s.ADslll.ss.cappacs..h......................t.t..h..................tt.....hlhDs+shh................................................	0	659	1277	1636
+4785	PF03721	UDPG_MGDP_dh_N		UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_1105 (release 3.0)	Domain	The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde  intermediate [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.95	0.71	-4.91	27	7072	2012-10-10 17:06:42	2003-04-07 12:59:11	9	27	3696	103	2033	10113	8347	178.30	31	42.76	CHANGED	h+IullGhGYVGLssusshuphG..hcVlslDIspp+lcplspGp.PIhEPGLpcllcpsh...pLphoschppslcpuDlhhIsVsTP.cp.....sptsDLpalpssscpluphlcp...tpllVh+STVPsGoscthhh.llpchstht.........hcatls.sPEFLpEGsAlpDhhpscRlllGspspsst......thhpcl	.................................................+Isl.l.G.h.GYVG.L.ssu..s..h..hApt.s........hc...Vl..u....l...........D............l.......s....t...........p.......+....l.....c....t.........l.............s........p........G......p............s......I......h...........E.....s.........s.....l......p.....c..........l.........l.....p.....p.....s.......h..............................................h..................p......l....p...h....o....s......c.....h..p.....p......s...h......p......p.....u..D.hhh.....I..A..V...s.T..Phct..................stp.s.D......h.....s..h.....V.....p.u.....s.s.c.s..lu.p...h.hpp.................hsll.l.h.c.S.T..VP.V.Gss...c..h...h.t......lh.c.p.h.ss..............................php.....ls..a..sPEhlp..pGp..u.l...hD...hh.p.s.sRllsGhssppst.........hh..........................................................................................................................	0	686	1345	1734
+4786	PF01704	UDPGP		UTP--glucose-1-phosphate uridylyltransferase	Bashton M, Bateman A	anon	Pfam-B_1634 (release 4.1)	Family	This family consists of UTP--glucose-1-phosphate uridylyltransferases, EC:2.7.7.9. Also known as UDP-glucose pyrophosphorylase (UDPGP) and  Glucose-1-phosphate uridylyltransferase. UTP--glucose-1-phosphate uridylyltransferase catalyses the interconversion of MgUTP + glucose-1-phosphate and UDP-glucose + MgPPi [1]. UDP-glucose is an important intermediate in mammalian carbohydrate interconversion involved in various metabolic roles depending on tissue type [1]. In Dictyostelium (slime mold) mutants in this enzyme abort the development cycle [2]. Also within the family is UDP-N-acetylglucosamine Swiss:Q16222 or AGX1 [3] and two hypothetical proteins from Borrelia burgdorferi the lyme disease  spirochaete Swiss:O51893 and Swiss:O51036.	19.70	19.70	19.70	19.80	19.20	19.60	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.43	0.70	-5.98	8	1651	2012-10-03 05:28:31	2003-04-07 12:59:11	13	13	879	45	747	1343	69	349.50	26	75.79	CHANGED	EhsuFhpLapRYlsc..spspplcWDcIcpPs.--ll.....cY-pLpt.s....pphuplLsKLAVLKLNGGLGToMGCpuPKSlIEV............RsshTFLDLtVpQIEpLN+pY.s.ssVPLlLMNSasTcc-TpKllcK..Ysss+lc.IpTFpQSpaPRlsKDoLLPlPpts..sS.s...-tWYPPGHGDlFcSLhsSGhlDsLLAQGKEYlFVSNlDN.LGAoVDLpILNHlIp....ppsEYsMEVT-KTpADlKGGsLhoY-G+l+LLEluQVPpc+l-EFKShpK.....FKlFNTNNl...WlsL+AlKRLl-sspLcL-IIsN.Kpl...s...........cslcllQLETAhGuAIppFcsuhGl.pVPR.sRFLPVKoo.SDLhLlpSsLYsLc.sGolphsstR.t.ssPll+LGsEFpcVusahpRlsuIP.sllELDHLTVSGDVaFGpNloLK	.....................................................................................................................................................................................l.................t.tt.h..s.....+huVlhlsGG...............GTph..G..h.ps.P..K..u.h..h..pl..............................t..p..t.hoh....h.p.....l.......s.p.p..l........t......p.......l......p........c........p..........h.......s.....s.......s.......l.P...h.hl.M..sS....Tcc...........s..Thp...hhc..c...........Yh....s...........h...p.hc...........lh.hFp.......Q.s...p...hPt.l.s.t.-u..hl.ltp.............ps.......s..........................t...............PsGpGs....lapuL........h........s..............u.......G.......h...........L....-c.......h.hpp..G..h.c...a.l.alt........sl.DN....Ls.ts....sD.h........hluah.....hp..............p..s....s-h.s.hc...ls.t+s...pss...tpsG..h..l.s...........p.....h...............-..........s.......c..........hp.............l...lEh...u.p.l..st..c........ht....th.p.s...pt.................hhh.F..N.s...s...Nl........ahsh...thlp..p.l........h..........p....t.......t..h..p...h..h..hh..s.K...p....l......c........................ssh.t.lh.....p.....h..t....h.......hh...hsl....h.a..........t.........p...s.h..........s...........l..pV.sR....pcF.PlKss.................................................................................................................................................................................................................................................................................................................................................	0	291	446	619
+4787	PF00201	UDPGT		UDP-glucoronosyl and UDP-glucosyl transferase	Finn RD	anon	Prosite	Family	\N	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.60	0.70	-5.95	14	8949	2012-10-03 16:42:30	2003-04-07 12:59:11	13	81	1315	25	4768	9465	106	279.00	18	62.32	CHANGED	GKVLVaPh-hSHWhsh+sllccLlpRGHElsVLtsuuohhlc.tcsuslphcsassuhopc-lcs.hhphhpphhhthsp.sshhphhsthp....chushhtssCpplltNKpLhppLpESpFDVlhsDslhPCGtllAcLLpIPhVa.LRhsPshhhp+tstth.hPsSYVPhllosLSDpMTFh-RV+NMlhhLhhcahhphh.pp.asphhSElLsRPsTls-hhu+AshWLlRshash-aP+PlhPNhsFlGGlpC+PAKPLspEhEtalpuSGE+GlVVFSLGSMVSshsEE+AphIAsALupIPQpVLWRacG.....p+PssLusNT.....hLhKWlPQNDLLGHPpT+AFlTHuGusGlYEuIppGlPMVshPLFGDQhDNht+MpsKGAuVoLNhtpMoSpDLhNALKsVIND.sYKENhMpLSplH+DpPhcPLDhAVFWlEaVMRHKGA+HLRsAAHDLTWaQYHSLDVIGFLLusVsslsFlshKsChasaRKhltttp+s	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p........................................p.u..l..l.h....luh................G........o..h...h....t.............s......p......p...........h........p...t..l.....h.......t.....u....l.......t.....p...............s.....t...........t.....h.....l.......W.....h......h...p..s.............................................t..........h.......t......p......s..h..........................hl..h...p....W.....h.....P......Q..........p..........l..L................s..................H.......s.................t................s.t.s..Fl.o.H.s.G....h.......s.S....s.h.E.ul..h..t.G.V.P.h.l..s...................h................P....h.....h.....u......D.....Q..........h.N....s.t.........h............h...........t...........p...........h...................t........h..........u........h........................h...............................t........................h..........p.....t.....t.....t......l......t...t..l..t...t.l..h......t...t........................................................................................................................................................................................................................................................................................................................................................................tth.................................................................................	0	1059	2520	3921
+4788	PF03152	UFD1		Ubiquitin fusion degradation protein UFD1	Mifsud W	anon	Pfam-B_3272 (release 6.5)	Family	Post-translational ubiquitin-protein conjugates are recognised for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified [1]. This family includes UFD1, a 40kD protein that is essential for vegetative cell viability [1]. The human UFD1 gene is expressed at high levels during embryogenesis, especially in the eyes and in the inner ear primordia and is thought to be important in the determination of ectoderm-derived structures, including neural crest cells. In addition, this gene is deleted in the CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate and hypocalcaemia with deletions on chromosome 22) syndrome. This clinical syndrome is associated with a variety of developmental defects, all characterised by microdeletions on 22q11.2. Two such developmental defects are the DiGeorge syndrome OMIM:188400, and the velo-cardio- facial syndrome OMIM:145410. Several of the abnormalities associated  with these conditions are thought to be due to defective neural crest cell differentiation [2].	35.60	35.60	36.10	35.70	35.00	35.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.95	0.71	-5.13	37	579	2012-10-01 20:15:13	2003-04-07 12:59:11	9	16	320	2	392	551	43	168.30	40	42.35	CHANGED	papppa+sYPluhh....c+p..plppGsKIlhPPSALscLsp....lpl..p.aPMlFcLp...Ns........psp+hTHsGVLEFlA-EGpsalPhW........................MMpsLtLpcGsh.....lplp.sssLPpGsalKlpPposcFLD..IosPKAV.LEssL.RNausLThGDhItIsYssppYtlcllEl.....KPss....AlolIETD.....lpVDFssP	....................................p.apt.apsashshh..............p+....phphGsK............l.hhPPSALcpLsp.................................Lpl....p..aPM..lFcLp.......Nt.........................ps.s..+hoHsGVLEFsA.-.E.Gp..saLPhW..............................................MMps....L.hLp....pGsh.............................lplc...ss.sLPhuoalKLQP..p.oss....FLD......I...os...PKAV..LEssL.R.N.F.us.LTpGDlls..l........s...Y......N...s........c.h.Y.c...l..pVhEs................KPss......ul...sll.ETD.....h...pVDFssP..............................	0	134	226	333
+4789	PF02512	UK	UK_protein; 	Virulence determinant	Mian N, Bateman A	anon	Pfam-B_2106 (release 5.4)	Family	The UK protein is an African swine fever virus (ASFV) protein that  is highly conserved amongst strains, and is an important viral virulence determinant for domestic pigs [1].	25.00	25.00	176.40	36.90	20.00	17.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.18	0.72	-10.40	0.72	-3.60	7	23	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	9	0	0	19	0	88.40	80	101.25	CHANGED	MSTHssSPKEKPVDhNNlSEKsuVVNNAP............................................................EKPAGANHIPEKSA.cMTSSEWIAEYWKGIKRGNDVPCCCPRKMTSADKKFSVFGKG.LMRShQKss	...........MSTHssSPKEKPVDMNsISEKSuVVNNAPEKPAGANHIPEKSA.EMTSSEWIAEYWKGIpRGNDVPCCCPRKMTSADKKFSVFGKG.LMRShQKss......	0	0	0	0
+4790	PF03044	Herpes_UL16	UL16_UL94; 	Herpesvirus UL16/UL94 family	Bateman A	anon	Pfam-B_4392 (release 6.4)	Family	This family groups together HSV-1 UL16 Swiss:P10200, HSV-6 ORF11R Swiss:P24442, EHV-1 46 Swiss:P28970, HCMV UL94 Swiss:P16800, EBV BGLF2 Swiss:P03221 and VZV 44 Swiss:P09293. UL16 protein may play a role in capsid maturation including DNA  packaging/cleavage [1]. In immunofluorescence studies [2], UL16 was localised to the nucleus of infected cells in areas containing high concentrations of HSV capsid proteins. These nuclear compartments have been described previously as viral assemblons [3] and are distinct from compartments containing replicating DNA. Localisation within assemblons argues for a role of UL16 encoded protein in capsid assembly or maturation [2].	25.00	25.00	42.80	42.80	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.20	0.70	-5.45	31	277	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	92	0	0	130	0	223.10	36	94.79	CHANGED	Ms.........tsthphl+pFLpcEClWhh.lssssph+lYpussshSshh...........tss.sssspslplplhlh+P+t.....pphhlslhlNGthh.....sssphchhhsptl.t.sphhllhFuslsssshsh..lPs.ss.pss..ssttls.stlhpsup..hl.sp-shsssshu............h.lG.sGAWh...p.ustslYhahls.DLhshCPsh.phPSLu+llsthssCcstt....Cs.Cpspt.tHVsshsshssssss..ussC.ChsPCthhcus....lslpuppsLhsllF.-sphthplsthpttpsslssslscllsGhsssGcplssssssWpLlplsshhSRhhlhuC.sLK+	...........thss.......phscRLLNDVsVWsp.VRsDshLpIhoAphsLppchp......ttspsss.ssssusLcIaLYLTKPKp.p.tp+ssHITslVNGs+A......hshLp+hssc+oPhG.uchashplu+sphsPsPhE.lPDPpsEP...........................................................................................................................................................................................................................................h.......	0	0	0	0
+4791	PF03252	Herpes_UL21	UL21; 	Herpesvirus UL21	Bateman A	anon	Pfam-B_3264 (release 6.5)	Family	The UL21 protein appears to be a dispensable component in herpesviruses [1].	25.00	25.00	56.20	56.10	18.10	17.20	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.73	0.70	-6.03	14	85	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	38	0	0	74	0	424.90	37	97.05	CHANGED	MEhpYpsslta..psVsFYlsssGsRAYFlCGGClhSVsR.....ttpsuElAKFGLsLRG.G.sD+slAsYVRoELtR.pG..hphuhPsscc-.....VFlDslulL..............s.ss...usEtDLCGth-lEVhDPtLA-ahVSLpsosGLllssuccpsp-+ll+LacsPslsNssSsFlYsPNpssFsLsQApLscLPsuLpsLVcGLFDsIPs..............sRpPlstps...ppT-VIlTupRAApsh............................hstttptstpst++sslSsFVQV+aI.......PRVhshWsspusss.................sstoLpcLhplhhtsDtllhcs........pthsGlspchspA..+sslsptstslFGptut.hsFlGt.....tshslossQ+FsLhQYllp+tchssCYshLccLscsYhss..pcssss..Dpt................sluDssNslhR-sshlGtsuEtllthshhpsth......................ssssupssps-ussLLclApsphth..s.........ssshppp+htcluthLstLYsGtshhsuAhphuchhGsuthlsshh-sphhoAF-cussu....p+hstYLtuLls	.............M-htYtpshha..psVhFYlststpRAYFhpGGClhSlsR......tpssElAKFGLslRG.u.ss+slAsYVRoEL..tppG.....ht.shs.spp-.........VFlDslslL..............t.ss...ss-hDlhst.-lEVhD.hLsch.hsSL.sssslhlssstshsp-phlcLhthPslss.ssStFhYsss..sFsLspApLscLPtSLp.LspGLFDslPs..............sR.sLsscs...p+TslllTupRAAcsl............................hsptpsptt+tt++sslSsFVQl+hI.......P.RVhshWsspttss.....................s.slptL.hlhhhuDcllhcs........pt.sG.LpcE...scA..ppslhptshslaGptGt.hsFhGt......uhsLoshQ+FslhQYIlpR.chhsCYsslccLscpYspt..psts..ss.ssps................hlsDssNtlhRcshhhG.hsc.lh.h................................sut.s..-uthlhchhtt..................shs.t..h.h.luhhLshlYtstshhssAh..sphhsss..lhhh.ph..hoAF-...hh....t+hhthl..Lh.h...........................	0	0	0	0
+4792	PF01499	Herpes_UL25	UL25; 	Herpesvirus UL25 family	Bateman A	anon	Pfam-B_700 (release 4.0)	Family	The herpesvirus UL25 gene product is a virion component involved in virus penetration [2] and capsid assembly.  The product of the UL25 gene is required for packaging but not cleavage of replicated viral DNA [2]. This family includes a number of herpesvirus proteins: EHV-1 36, EBV BVRF1 Swiss:P03233, HCMV UL77 Swiss:P16726, ILTV ORF2 Swiss:P23987, and VZV gene 34 Swiss:P09287.	25.00	25.00	50.40	50.30	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	540	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.52	0.70	-6.20	15	156	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	90	1	0	140	0	513.80	29	94.47	CHANGED	hthhhts..hh.scs+Nhltsshsshphsp.phutphRspt....phchsph++c..hlpAELDsLttpptstssplsscLcslEp......tltchsps.sslp...............................ssspusppssssps...hs.hstspsssh...............pVsIs.sDPslpacsshps-hlsslYsspupWsso....FGsWYtsLpcshhpcRhhP+sh+ussstssohStcLMssslssLpussphahuDppahuDpsAALCLlsAYh.....utpsus.hP....sohs-LLppLPphlchLss-lpstps..usssapFshsc.sppphhuPhs+tt+YspssFssHtlhshLh+tGVlsthsGt...........scssGsshsD.-lsh...slsshlhusslPhhsccQhhLRuGlsuIpuLlLlapLLpsusVasc+ss+phpLuuLls.sthssss.......ss.utpssshpt............spNFpFLhccYVlPhYptsspsslopLFPGLsuLslstpsttussstpt......hlslous+aQ.....slhcllstcLpp+cs.......stllsAHDuLtlphEcGLulLLppspPppu.hpshtpuQFsV	........s........hhh.scscN.hltss..hhhhhp.thshshcstt...pphthtps++p..hhtstL-sLtt....pttshst-lcp+lcslEp..........................plpph.sssh.....sshp................................................ps.stssptsssuts....tt.ssstssss.tsts................................pltIspNDPsl......pac.oshps-llshlYsspsshsso.....FGsWYtpLpcthhsc...PpshRhsphcssphSpphhssslsuLpssshhhsssp.h.u..pAsLCLhhhYt.............shtss..p.phP.....sohtpLlppLPphl....ctls....ppls....s.....p.......stsshtashpc.Pctpahs.Phsp...YptGshspHsllthLh+puVlsthPG...t..................t..st.phsssstsD.clsh....thsshhht.tps.hhhc-QphLRuslsslsuLlLlh+LLtsssVa.us+hsphhpLuslls.sssssts......sss.stptsh.ht..u...............................tspNFpFLhppYlsPhYttsPs.lplopLFPGLshLslstp..st.....p..shsssp+...............slshuusthQ..........tslhchhhhph.pp+pt.......hcllpsHDulhhpaEpGLGhLhp.shstpt.hpsht.stFNV......	0	0	0	0
+4793	PF04496	Herpes_UL35	UL35; 	Herpesvirus UL35 family 	Finn RD	anon	Pfam-B_3981 (release 7.5)	Family	UL35 represents a true late gene which encodes a 12-kDa  capsid protein [1].	25.00	25.00	27.80	28.20	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-9.97	0.72	-3.80	11	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	30	0	0	30	0	99.00	38	74.64	CHANGED	ssFDPssPsThos-slpshs.VsLlphLNss.tslpsusptsp.lssA+psllhGtusuhsclR+pHsspTlpRssMFApsDsuoWlRPolGLKRTFsPtlhp	......sFDPssPsThos-slcshh.V-llhtLNss.t.lpsspptsthhpsA+pslhhGtusuhsclRppHsspTlpRpsMFAssDsuoWlRPolGLKRTFsPtlh...	0	0	0	0
+4794	PF03970	Herpes_UL37_1	UL37;	Herpesvirus UL37 tegument protein	Finn RD	anon	DOMO_DM03155x;	Family	UL37 interacts with UL36, which is thought to be an important early step in tegumentation during virion morphogenesis in the cytoplasm [1].	25.00	25.00	30.40	30.30	18.60	17.80	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.76	0.70	-5.59	9	82	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	33	0	0	78	0	264.90	37	25.28	CHANGED	stspshshpsLLssLtuL........upsssstcshssthsucsRsuIupFhhSosplslppscshW+cLhp...slhclYppot.PEAAhLAcNhsGLlhWRlslpWscs..phh-phcpL+plshthTupEslphLopNsLRhSAshGPsshp.hlo-WhshFcssspsshshoscshhpuRt.h........ltphsAuLsppRFsLIYDhPFVQEGlRlluttssWlsPFslhhpphpssshT..PLTRsLFhluLlDpY.hssssssp.....Lp-hFs-slptls	.....................................................................................................s.s.phshppLLssLssL........sppsssscs.u.htsuchRuuhutFLLSssslsstcsctpWc..sLhp...tlCtlapspthPEsAhLAENLPGLllaRLslshscs..pshcphchlpchlhshsus-s.ptLssssLRsuAshG.PVph+thls-WlspapslscsshshsPcs.hcAhttts........lspssAsLsp.tauLlashPFVQEGlRhLuhsushls.FsshhpplssuoLT..PLTRALFTLuLVDEY.hsssptss..s..LhttFtcsVptIc.................	0	0	0	0
+4795	PF02282	Herpes_UL42	UL42; 	DNA polymerase processivity factor (UL42)	Bateman A, Mian N	anon	Pfam-B_5119 (release 5.2)	Domain	The DNA polymerase processivity factor (UL42) of herpes simplex virus forms a heterodimer with UL30 to create the viral DNA polymerase complex. UL42 functions to increase the processivity of polymerisation and makes little contribution to the catalytic activity of the  polymerase.	20.80	20.80	20.80	25.70	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.76	0.71	-4.63	12	135	2012-10-02 11:47:48	2003-04-07 12:59:11	11	2	32	8	0	135	0	137.10	27	63.67	CHANGED	sphsLsctpLsclhushts.ssshtssFhlhsccshhlpsshtupplhhslptpthsph.......ss.tlhLu.s-uppsLl..hthspt.psht............phshtlcspsshRpLlQplhhssst..........ht..hss.sss.hslhppp.sshshhh	.....................splsLpcspLscllsuhus.tss....hhsohhlhsstshhlasohhuppVhhslcpsthSph.......ss..h..u.scuppsLl.shthspt.psst............phslslsspsshRsllQ+lhsssut..............hss....pssuhslhtpt.suhsshh......................	1	0	0	0
+4796	PF03117	Herpes_UL49_1	UL49; 	UL49 family	Mifsud W	anon	Pfam-B_2110 (release 6.5)	Family	Members of this family, found in several herpesviruses, include EBV BFRF2 Swiss:P14347 and other UL49 proteins (e.g. HCMVA UL49 Swiss:P16786, HSV6 U33 Swiss:P52441). There are eight conserved cysteine residues in this alignment, all lying towards the C-terminus. Their function is unknown.	25.00	25.00	53.80	52.70	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.04	0.70	-5.28	16	80	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	52	0	0	75	0	247.60	42	50.98	CHANGED	hsspspuLlsAL+ppussVPCGNPh.sMs+sLshpsshpss+sllPlspp........................................................ssplspplhsplLuhslLusllslPlhshsht+shRtttsts.......hhsVlCt-CGHCLNhGKsKhps...hsFsPosh.FYsRDpKEKphhhCssoGRlYCShCGSpplpshplhEhs...h.hGh..shl..RAVlusNAAhslpssspphDlllPChuostsCtu.slL+clolpcLLhLT..upssphhCt+Cps	.......s..phpuLluuLRccuupVPCGNPlasMs+thlppaCtsssRaLlPlpshsht.tsp.......sts.........................................h..p.s+lshaulussLRsGLluSVI-LPlhChs+hKCpRahcsts........lhAVVCppCGHCLNhGK-KLcsp..psFsLNSh.FYYRD+QEKuVlassps-hlHCSLCGSpplspp+lYElsptshhGt...hpVp..W+AVlG.NAACulhstphthDlllPC..usRoC.usVllRtloV.+LLpLT..SHupshhCt+CQ....	0	0	0	0
+4797	PF03121	Herpes_UL52	UL52_UL70; 	Herpesviridae UL52/UL70 DNA primase	Mifsud W	anon	Pfam-B_203 (release 6.5)	Family	Herpes simplex virus type 1 DNA replication in host cells is known to be mediated by seven viral-encoded proteins, three of which form a heterotrimeric DNA helicase-primase complex. This complex consists of UL5, UL8, and UL52 subunits.  Heterodimers consisting of UL5 and UL52 have been shown to retain both helicase and primase activities. Nevertheless, UL8 is still essential for replication: though it lacks any DNA binding or catalytic activities, it is involved in the transport of UL5-UL52 and it also interacts with other replication proteins. The molecular mechanisms of the UL5-UL52 catalytic activities are not known. While UL5 is associated with DNA helicase activity and UL52 with DNA primase activity, the helicase activity requires the interaction of UL5 and UL52 [see 2,3]. It is not known if the primase activity can be maintained by UL52 alone. The region encompassed by residues 610-636 of HSV1 UL52 Swiss:P10236 is thought to contain a divalent metal cation binding motif. Indeed, this region contains several aspartate and  glutamate residues that might be involved in divalent cation binding. The biological significance of UL52-UL8 interaction is not known. Yeast two-hybrid analysis together with immunoprecipitation experiments  have shown that the HSV1 UL52 region between residues 366-914 is essential for this interaction, while the first 349 N-terminal residues are dispensable [2].  This family also includes protein UL70 from cytomegalovirus (CMV, a subgroup of the Herpesviridae) strains (e.g. Swiss:P17149), which, by analogy with UL52, is thought to have DNA primase activity. Indeed, CMV  strains also possess a DNA helicase-primase complex, the other subunits  being protein UL105 (with known similarity to HSV1 UL5) and protein UL102.	20.80	20.80	21.00	20.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.84	0.72	-4.24	38	329	2012-10-02 15:26:12	2003-04-07 12:59:11	10	8	214	0	89	310	49	69.60	23	8.88	CHANGED	shtpsshhllplp.........+spsFtClphpHppp.pps...........splalslpssp.ttlhhshhppCF........usK.........CssNphpsthoshss	..............h..pthhlhplt.........p.tshhChpht+t+pups..............lalslchpp.....hshhQ+Ca.......ssc.........Cpspthps.h.....s....................	0	37	49	70
+4798	PF03049	Herpes_UL79	UL79; 	UL79 family	Bateman A	anon	Pfam-B_2433 (release 6.4)	Family	Members of this family are functionally uncharacterised proteins from herpesviruses. This family groups together HSV-6 U52 Swiss:P52469, HVS-1 18 Swiss:Q01003 and HCMV UL79 Swiss:P16752.	20.50	20.50	20.70	21.70	19.90	16.20	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.43	0.70	-5.31	19	61	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	50	0	0	55	0	246.10	36	92.22	CHANGED	hlG+alh.pspshoshlhplhhKllpGpsLsohp.-EL+hl+LlhsphashGLplhLLREslsNsGspDsslLsRKVPsEaWphlY-shcphssssc...hLhsEsptupLhh+Ls.pssslhphlspalhpchGL..tlplssp.lpDGNhLFsLGoVhspRLlhlhtFhhhaWGppphEPhVRhhspKlahhYLIlsG+Lplptshap.psssphsGlhphlhpDhhuapG....slspss.............h.p.tp.hDh..lhlhsssl	...hG+al..phsshsphlhpIhpKhhpGpsLsoh+.EEL+ll+LlhshhaphGLpshLLREshsNsGlsDssVLuRKlPspaWhhlYctLcphssstc...hlhsEspuApL.h+Ls.ps.th.hthlscalhcchGL..slslsp-hhpDGNlLFsLGolhsaRLhhlstFhhtaWGpppaEPhlRhhspKhahhYLIhsG+lpls.ssap.ppopc.sGlhshIhcDh+sFtG....slstps.phhp.pp.........................	0	0	0	0
+4799	PF03043	Herpes_UL87	UL87; 	Herpesvirus UL87 family	Bateman A	anon	Pfam-B_1736 (release 6.4)	Family	Members of this family are functionally uncharacterised. This family groups together EBV BcRF1 Swiss:P25215, HSV-6 U58 Swiss:P24437, HVS-1 24 Swiss:Q01007 and HCMV UL87 Swiss:P16730. The proteins range from 575 to 950 amino acids in length.	25.00	25.00	25.40	25.40	24.10	24.70	hmmbuild  -o /dev/null HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.86	0.70	-6.12	19	90	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	54	0	0	80	0	494.10	43	72.04	CHANGED	tLht.hpssp..........hshhP.hssspsththtcF.lLphhptW.s....Nsshtchtpplhpslpppsthlhhhh+hssppslplpshslhcapptl.hhh.p.lphpppK+tst.tshthslsp........ppthltasss..sslaRshhsh....................................................................................................usucplspspsshp.ssptss.......................sRthVshhcRlpaAP+ct............................................shshththp....................phpspsttp.shtppFsslsplSls.sF+VNlFNTNhVINTKlsspptss.....pslhslP+.LTpNFVh+KaohKEPuFTVSlFaSsDhs.pssAINlNIsGshlpFLaAhush+CalPIcslF.PAuluNWNSTLDLHGLENQslVRssR+cVFWTTNFPSslSspcGhNVSWFKAATAsISKlpGpsLpsplh+Els.IlshppAplshsKNplFThLEpRNphQIQsLHKRFLEsLatpsuhLRLs........s+slh+lsppGlFDFSK+hlAHoKsKH-CAL..lGh+hsNslPKllspsKKhRLDcLGRNANaLohh+psspp...hsth+tpll++ll+pLu.....l+p+	...............................................................................................................h.....ht.p..........hshhP...s.hs..t.hcF.llph.p.Whs....ptshtchhtplhtphpp..thlhhhh+.stppshtlpthsh.capptl.hh....p.lphtpp+p..............t.hcshlhh........pph.lhassp..sslaRslhhh....................................................................................................uhst.hh.sps..t...........................................spthlthhpRl.as.ht.............................................shs....hth........t............pt.s.sttp..hs.pFs.hptlols.phtVNsFNTNhVINhKhshpphst.....hph.plP+.hTpsFVhhKaohKEPuhTVSsFhSsshs.hhsulNlNIpGsh.cFLauhush+halsIcphF.PAslsN.NSoLDlHGLEsQsllRstRpcVaWTTNFPshlSppsslNVGWFKAATAIlP+VSGssLEslLLKELshIpshcplslDas.LHRlFThLEpRNsYQIPFLsKQhl..LFlRsshL+LpGhtpc..lc+hlhcAspcGlFDaSKphhuHTK.KHpCAL..lG.RhsNslPKllspsKKh+LDcLGRNANhLohh+phttt...hsth+hpllhcllttLt.............	0	0	0	0
+4800	PF03048	Herpes_UL92	2111; UL92; 	UL92 family	Mifsud W	anon	Pfam-B_2111 (release 6.4)	Family	Members of this family, found in several herpesviruses, include EBV BDLF4 Swiss:P03223, HCMV UL92 Swiss:P16798, HHV8 31 Swiss:P88920,  HSV6 U63 Swiss:P24440. Their function is unknown. The N terminus of this protein contains 6 conserved cysteines and histidines that might form a zinc binding domain (A Bateman pers. obs.).	20.50	20.50	20.50	20.80	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.51	0.71	-4.73	18	82	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	66	0	10	71	1	162.60	28	70.67	CHANGED	pCphpplpsslTphpslsslYhCspCtcYHVCDGu.p-CsllsTtEGhVCthTGpshssslpsssthsspshpcsp...tphp.p.hhNllpslhpclhpYhppsss.hsclppplh.scGpLpccltslIphTFscChplhsshpps..hsllsSlYIHlIISlYSs+TlYsshlFKsT+NK+aDsllKpMRppWMssL	..........Cphpplpsshs.p.hpltslYhChpCtphHlC.Dts.ppCslls.T.tEu.hVCshTGhshtshhsssp.h.h.pshppst....p.......shltslhp.lhpah.p.s..hstlhpplh.ptsthp.pltp.l.hTFtpshp.hpth..pth..hsllsphalplIIulauptThYsshlhKso+pK+.DslhKphR.tahss.s...................	1	2	8	9
+4801	PF03038	Herpes_UL95	UL95; 	UL95 family	Mifsud W	anon	Pfam-B_2060 (release 6.4)	Family	Members of this family, found in several herpesviruses, include EBV BGLF3 Swiss:P03220 and other UL95 proteins (e.g. HCMV UL95 Swiss:P16801,  HVS-1 34 Swiss:Q01023, HSV6 U67 Swiss:P24444). Their function is unknown.	21.60	21.60	22.30	23.20	18.70	21.50	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.11	0.70	-5.57	20	82	2009-09-11 15:08:21	2003-04-07 12:59:11	9	2	52	0	2	72	0	333.20	36	87.25	CHANGED	MhsLsphp..scscsphsc+YpcuVcLALshCEus.P.sQFKLIETPhsSFLLVTNVlPc-ssshsstss..............................pthchpslphs+hpthptlhshphpsstpptsssss.................hhp.psphhtssYllYcppphphALshNKssllppsLchlssPspWsappssDPLslLWLLFhGP+SaCpcssChhtc+hGp..PGPlLLPPhhYcPspDlpoFhshsppYVhshYpch..................................................us.h.shshsPFchsRl+cslppl...schsspslhl....S+pCLLCsLY+QNph....uppss.ssshu.hIILsstutphhso.....htsp+pssousslLaPsYslssLlsslstsssu	..................................................................................Mhtlst.p....schsst.shRaccuVphALssCEus.P.-pF+LIETP.psFLLVTNllPc-ps.h.shss.................................pt.phpphphsc.sths..h..hcppsshpthsssst..............ss.t.hs.psphhhssYllYpKpphchuLo.NKsphlptsLc.lhsPshhsapsspDs.slLWLLasGP+SaCtcssChupc+tGp..shPsLLP.hhYcPspDh.oahshsphYVashYcshch..................................................u..p.h.ph.hhPhshsRl+cslptl...tchsscplsh.....SRsCLLCsLYpQNcl....Appcs.sssauPllI.sstushp.lo......hoahhPupssssLaPsYclupLlssls.sptu.........	0	2	2	2
+4802	PF04817	Umbravirus_LDM		Umbravirus long distance movement (LDM) family 	Finn RD	anon	Pfam-B_5103 (release 7.6)	Family	The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants [1].	25.00	25.00	33.60	33.10	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.44	0.70	-5.22	4	24	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	8	0	0	24	0	226.80	42	93.30	CHANGED	MoSlINV.ssuKSppscGsstSSVRtGcpptsPtsKPtusHssSR+sKGssHPAsTsKcsppslpuspAsssHpcHtGssl.tEusGuVHssRstRRuRRuGuMcsRQ.TsQPppRtscsch.sERRAplDGLLPPLLDTlsGph.GsAtlLhaCltAl+RpLRp+h.cPlQsspcVAuopGcsssQLs-puspsutsLssDGtGRAstus..psl.pGusV.pVCssCsts	...............MoolINV.ssscu+psRGsspsSlRtGcpctAttsKPtsspsPsRRppGGsaPusss+cspcshptspssssHppHtGoslhREusGGVHssRstRptRRuushuPRQpsssP+QRhApsclssERRAplDulLsPLLDTlctpspGsAslLLaClsAlRRELRc+h.cPVQPsHsVuuoptppusQL.-puspssssLpssGcGpustss.ppslpptssV.pVCssCsh.s..............................	0	0	0	0
+4803	PF00021	UPAR_LY6		u-PAR/Ly-6 domain	Sonnhammer ELL, Bateman A	anon	Prosite	Domain	This extracellular disulphide bond rich domain is related to Pfam:PF00087.	17.70	10.00	17.70	10.20	17.60	9.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-10.76	0.72	-3.56	40	1221	2012-10-03 01:43:02	2003-04-07 12:59:11	16	8	118	68	543	1327	0	74.40	20	55.41	CHANGED	CasCht..tspsCpss.....sCstspsh....Chsspsth..ss...psphhh+sChp.stC.........ph.shthphstsslph...........sC.CppsLCN	......................................ChsC...ht....s...sts......Cpst.......hpCss.s..psh....................Chs.....s..p....s.....p...h.t..........s..t........t.s.ph.hh+..uC..s.......stC..............p........t.h...s.......h...p...h...ph..................pC..Cp.tshCN.............................................	6	39	65	185
+4804	PF00919	UPF0004		Uncharacterized protein family UPF0004	Bateman A, Moxon SJ	anon	Pfam-B_1257 (release 3.0)	Family	This family is the N terminal half of the Prosite family. The C-terminal half has been shown to be related to MiaB proteins [1,2]. This domain is a nearly always found in conjunction with Pfam:PF04055 and Pfam:PF01938 although its function is uncertain.	21.30	21.30	21.70	22.20	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.67	0.72	-4.16	160	8275	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	3943	0	2232	6265	3365	97.10	32	21.38	CHANGED	+lhlhThGCphNhhDSEhhtuhLppt.Gaphssp...c.cADllllNTCulppsAcpcshppltchpchc............st.............................thls...........VsGChuQpts..cclhcths..hDhllG	.....................lhlhThGCphNhh...DSEthhshL..p.s.t........G......Y....p......h........s.........s...s..........c.....c............A.....D..........ll..llNTCulp-pAppcshptlsc..htphp................t....................................................................................................................................hhl.s................VsGCh.up.pps...c..p.l.h.c.p.h.s..VDhlhG......................................................................................................	0	840	1539	1927
+4805	PF03649	UPF0014		Uncharacterised protein family (UPF0014)	Bateman A	anon	SWISS-PROT	Family	\N	20.50	20.50	20.70	22.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.77	0.70	-5.22	3	1867	2009-09-14 12:52:49	2003-04-07 12:59:11	8	5	1800	0	366	1096	131	235.30	37	93.21	CHANGED	hpHsllpL.ht-LuaALhLVllAILIua+EKLuLEKcILWuuGRAIIQLIIVGYVLtYIFSlDsssusLLMlulMlTlAAalAp+RINh+uKohlu.aLaITlGAoThISL...AVLIIssslcFpPhYVIPLsGMIlGNTMNoluLAh-+LustVpSEpcpIps+LuLGATPtQAlAsaIRsAIRAALIPTVNpsKoVGLVSLPGMMoGhlLAGuDPlpAucYQIlIMFMILSTAoLSTIllCYLsYRcaaNu	.......................................s............sLsl.uh..h.L.....l.l.l.s...l..h...lS.h...t...p...+L......ultK-llhushRAll....QLlll.Gal.Lp.Yl.F.p..l..s..s.h.hl.s..l.Lh.l..lhh.hh.sA.u..a..s..s.....tpR...u.....p.....h.....h.....h....+...s...h...h...............h...l...u...l.s..l..s..s...u.............l..s...L......sl...l....l....l..s..s.sh.....a.tP.t..tlIPIuGMlhGNuMsA....luLshppLtpphpp.c....ppplpptLuLGATs+pAutshl.Rcul+sullPTlDSs+Tl.GLVSLPG..MMoGlIluGssPlpAI+YQIhVh...Fhlh.uss...ul.o..sll.A.s.hLsY+paas........................	0	125	227	309
+4806	PF01169	UPF0016		Uncharacterized protein family UPF0016	Finn RD, Bateman A	anon	Prosite	Family	This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.55	0.72	-3.84	145	2676	2012-10-03 02:02:08	2003-04-07 12:59:11	14	8	1140	0	1249	2385	333	76.00	30	60.26	CHANGED	a....h..sohshlhlAElGDKTQlsslsLAuth.tpsh.sVhhGsslAhhlssslulhh.Gphl.......sphls.p..hlphluullFlhhG	..................htohshhhlAElGDKTQlsolhLAuca..........s.....h...sVhhGshluhhlsss.....l...ulhh.G.ph.l...........ushl..s.p......hlphluullFlhhu...............................	0	407	768	1060
+4807	PF01170	UPF0020		Putative RNA methylase family UPF0020	Finn RD, Bateman A	anon	Prosite	Domain	This domain is probably a methylase.  It is associated with the THUMP domain that also occurs with RNA modification domains [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.09	0.71	-4.70	16	3872	2012-10-10 17:06:42	2003-04-07 12:59:11	13	26	3399	14	1064	14743	3401	195.00	31	40.56	CHANGED	RsaRsastPusLpssLAtAhlpLushpsspsllDPhCGoGTlhIEAALhutphh...........................................hGsDhct+hlpuA+hNsppsGlschlphhphcsspLp...hss....ps-sllosPPYGh+lupptsl.ppLYpphhcph+chhps...hhshhhspppshppshppt..shcththhplthushpht	...............................................................................................................................RGYR....t.p.Gt...APl+.E.s.LAA...ul.l........h....h...........o........s....W..........p............s..........s...........p.........s.........l...lDPhC...GS...G..T...l..h...I...E......A..A...h.h.u.t..shAP.GhpRthhh.ph..............................................................................................................ttttttt.p........php.....hh..G....s.....D....h...D..s......c...h....l.......c.......h.........A......+............p........N.........A.........c.......p.........A............G.......l...........s.......c...........h..........I.............p..........a........p.....t....h......c...l....p....p...lp.....................spt.................thG...s.....l.l...s....N..P....P...Y...........G.....E.......R....l.................s.................s........c..........t.......t........l...................t.L........Y......p.....t.h....G...p.h..h.cp..hts..........hphh.lh..o..u..p......p..h....p.h.hthp......us+ph+hhNG.lcs..........................................................................................................................	0	349	629	868
+4808	PF01171	ATP_bind_3	UPF0021;ATP_bind3; 	PP-loop family	Finn RD, Bateman A, Yeats C	anon	Prosite	Family	This family of proteins belongs to the PP-loop superfamily [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.14	0.71	-4.79	33	7781	2012-10-02 18:00:56	2003-04-07 12:59:11	15	37	4816	13	2118	7133	3921	174.70	26	46.74	CHANGED	phllAlSGGsDShsLLhlLtchttp..h..........plsslHlcHslR.p.pucp-tpalpphCpphs..lslhltphsh......st.....tpslEptARchRYchhpchhtppshphllhAHHtDDQhEThlhpLhRGsuh.....tuLsu..hts.....tp.h........ts.hpllRPLL.shs+p-l.pascppplsahcDpSNts.pYp.RNplRpp	................................................................lhlulS.G.GhDS..h.s.LLp..lL...t...p..h....p..p...p.h.sh...................plts..l...p...ls....a...s...h.....p.....t........t.....u........t.t..........t...p..hl..p.p..h.s.p....p.h.s.............l..s.....h...t.l.hp..hsh............................t..t.....s.p.s.h.p....s.....h.......u......R........p.............h............R..................h...........t...........h...........h....t.....c....h.....s..............p...........c..........h......s........h.....s...............t.............l....shu.H......H..t.....D.......D.th....E.....T.h.lh.....s..l.h..+.G..u.th............t.s.l.t....u...hs...........t.p..................................................................ts...hhl...lR...PL..l.........hh........p.c.p......-..l....h....p....a............sp..........t.....p........tl.........h..h...D...s....s....t....h...R.............................................................................................................................	1	734	1357	1799
+4809	PF01172	SBDS	UPF0023; 	Shwachman-Bodian-Diamond syndrome (SBDS) protein 	Finn RD, Bateman A, Moxon SJ, Mistry J, Wood V	anon	Prosite	Family	This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.  It is characterised by bone marrow failure and leukemia predisposition.  Members of this family play a role in RNA metabolism [2] [3].  In yeast these proteins have been shown to be critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes [4].  This data links defective late 60S subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition [4].	24.40	24.40	25.50	27.00	20.00	24.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.81	0.72	-4.19	103	652	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	473	7	444	614	94	91.60	36	38.64	CHANGED	ssssll+h+.p...tGc+..FElllhsspshpa+.........pGp..........phsls-VltspplFpss...s+Gpp.....AucppLppsF.......G.Ts-hpclhcpILc+GElQloscpR+ph	.............................ssslVRhK...p...tGc+....FEl..hs..a....s...c...l...hpaR.........sst.................-tcL--VLps.ppVFtss....uKGpt.......................Ascp-LppsF..................................G.Tsc.p-Ihpp..............ILcKGE.lQlopcpRpt......................................	0	143	255	370
+4810	PF01142	TruD		tRNA pseudouridine synthase D (TruD)	Finn RD, Bateman A, Moxon SJ	anon	Prosite	Family	TruD is responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs [1].  The structure of TruD reveals an overall V-shaped molecule which contains an RNA-binding cleft [2].	19.20	19.20	19.80	19.20	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.33	0.70	-5.79	69	2142	2009-01-15 18:05:59	2003-04-07 12:59:11	13	12	1702	7	755	1714	284	327.60	28	79.21	CHANGED	M....................sth.h..htstPtssupl+sp......P-DFhVcEhh..s.hpssG.cG-H.lhlplcKpuhsTttlscplA+hhslst+cluaAGhKDR+AlTpQahSl...hsspp......s.ch.........t......slpllphs.RHs+KL+hGsLtGN+FpIhl...R.sls......st...lppplptlttt.GVPNYFG.QRFGps.usNhhhupthhpu................thp.......tc+....................................................ph+uhalSAhpSaLFNpllSpRlc......ttshspslsGDhhhhts.........stshhhspt....tthpt+ltptclp.ouPLhGp.sthhs.pupst.phEpplLsptsh...hhp...thtphth...cstRRslhlhs.pshp......h...sp.....slplpFtLPsGuYATslLREl	...................................................................................................................................h..................t....t.shhpt..........spDF.V.E...............................h...............t...................s............u....p..........G.....-..a..lhlplhKpshsTh..sh....phLu+....hh....t.l.....p.....+.......p.lu..aAGhKD++AlTpQahshp...hsttp............hssh................................................c....shplh.phs..h+pcKL+lGsLpGNt...Fplh.L.............R..pl.......s............................ts................................lc....pt....L........p...........pl................p.......p................t....G...h.sNYFG.QRFG..t......t...........s..s..........s.........h.......p...........huh..phhps......................................ph.................hppc..........................................................................................................................................................................s..h..Rphals..AhpS...hlFNphlupRlc.................phshp.ps....ltGDhl.hts...................................................ptph.ah.s.....p.t.........tt...ppchtt....t.c...l.................hs...us.L....Gt...s.hh.......s....ptt...sh..th-pthl...stp...s..........ht..........hhh.p....p.h.........p...usR...Rhhhhhs..p.plp.ap..h.....pt...............................................slplpFhLstGuaATsllREl.................................................................................................................................	0	257	430	625
+4811	PF01139	RtcB	UPF0027;	tRNA-splicing ligase RtcB	Finn RD, Bateman A, Eberhardt R	anon	Prosite	Family	This family of RNA ligases (EC:6.5.1.3) join 2',3'-cyclic phosphate and 5'-OH ends. They catalyse the splicing of tRNA and may also participate in tRNA repair and recovery from stress-induced RNA damage [1-3].	20.00	20.00	20.00	20.20	17.80	19.90	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.67	0.70	-5.48	136	2812	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	1686	6	719	2149	307	317.50	32	93.53	CHANGED	hpssshlas..ptthl-..................stulcQltslA.sL.....Psl..hc..shsMPDsHhGhG.hsIGuVhuhc.....uhlsPuuVGhDIsCGhphlpT.sLphp-l.....p.s...ph...pcLhstlhcslPsG...........hs......ttst...h..pthpphhtpthphsh.cpth.tht.................................s.ptlsppstp+ut...........t........QLGTLGuGNHFlElp.........h......th.t......h.slpc........sp....lhlhlHoGSRGlGppluscalchhpp....th....tcht...h..pls...........................................................Dc.pLAhhshsoptupcYlpAMshAtsaAhsNRphltchltc........................sh...pphh.........hthphl............h-lsHNhs...........chE..............pH....................tpplhVHRKGATRAh................hGp.llIPGSMGssSYlltGpttutt.......oasSssHGAGRhhSRspA++...................phshccltcphtt.......lpspspps................lh-EuPtAYKcl-pVlpsh..sslschVs+L+PlsslKG	........................................................hhs............l-...................t.uhpQl....hssA....ph........Phh..hp.....hhsMPDh.H....G...h...G....hsIGushshp.................shl.P..uhVGhDIsC..Ghthhps.sl.ttch.......t........p.h.tp.hhptl....ph...hs.u........................................................................................................................................h.pp.h..........................tplGolGsGNHFhElp.................................................lp..t...sp................lhlhlHoGSRGlGptlsp....ahthht.................................................................................................................................................................thshh.....to.....h...pp...Yhtthth...A.taA.hNRphhht.hhp..........................th..tt..............h.....................hsstHNhs.............phc...........................h......................pphhlpRKGAs..u.................................Gt.hl.IPGoMGshSalltGh.ss..................h..hSssHGAGRhhuRsp.s+p.....................h.sh.pp...pt.htt.......l.spp.t.................hh-Eh..........P.AYKs..lctVhts.......tslhphhhpl+.lhshK.....................................................................	0	285	480	624
+4812	PF01205	UPF0029		Uncharacterized protein family UPF0029	Finn RD, Bateman A	anon	Prosite	Family	\N	20.50	20.50	20.70	21.10	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.35	0.72	-4.37	179	4099	2012-10-03 01:04:38	2003-04-07 12:59:11	14	14	3898	2	953	2747	154	107.50	44	49.97	CHANGED	lK+S+Fluhht.lssp.p......-spphlpplcppa.c....AsH.psaAahl.....s.tssp....................................h.chsDDGEPuGTAGpPhL.plLpt....p.......sltslslVVsRYFGGl+LGsGGLlRAYssusppulp	..................................................................lKKSRFIshl.t...lps..-.........-A+sa..lppl+..p..c..+hc.........AsH.sChAahl.....G.t.p.s..p...................................................................................................h.choDDGEPuG.T.AGhPhL.shLpt....p............slssls.....lVVs...R.....YFGGI..+LGsGGLlRAYususspul.t.....................	0	306	605	816
+4813	PF01256	Carb_kinase	UPF0031; carb_kinase;	Carbohydrate kinase	Finn RD, Bateman A, Yeats C	anon	Prosite	Family	This family is related to Pfam:PF02110 and Pfam:PF00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.45	0.70	-5.09	9	4484	2012-10-03 06:25:16	2003-04-07 12:59:11	12	18	4216	36	1246	6104	1631	239.10	30	56.40	CHANGED	shlluGspsasGAslhuuhuAhphG..sGllpVts..sshsslpshhPclhscsh............st.h....thhpphcslllGPGLGps.th......hlphlLspppP...lllDADuLthls.p........sthpssslLTPHssEFtRLsssss..........tss+.phspphupphsssllLKGstsllss...suslhhspsGsushApGGpGDVLuGhIuuhLupst.........sshcAshsusahHutAuphhspctuh..shhsspltchlsp	............................................................................................................................................h.hllGG.....s.....t....s....hsGAs......h......h.....u....u......t....A..A....l......+....u....G..................AG.L...V..................p....l..h.s.......t.......p.....s.....h....s....s....l....t..s...t.....h..P..E...h..M.s.tshp.............................................t.h........t........h....p..p.......s....s..s....l.l....l...G....P....G....L....G....p.....s....p.h...s.tp................................hl.p...t...l.....h......p.....p....t....p...P.....................lllD.............A.....DAL..s..ll.upp.......................................thpp.p..h.....l.....lT...P.....HssEhs.R.L.h.u.h.sh.t........................................hpp..s...+...h.t....s...s....p....p..h...s..p......c...h.....s.....s...s......l...V.........L.........K.........G........s........s............T..........l...........l........s..s........................ss.....p.......h..h....l.......s....s....s....G........s.........s.........u...........h........A........o...G.........G.GD.V....L.uG.hIu..u....l...l.u.Q.th........................................ss...h-.A....u..t..s....u.s..h....lHu...hA..uch.hs.t.p...h.....hhsscl.t........................................................................................	0	429	805	1066
+4814	PF00902	TatC	UPF0032; 	Sec-independent protein translocase protein (TatC)	Bateman A, Moxon SJ	anon	Pfam-B_1212 (release 3.0)	Family	The bacterial Tat system has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. It is structurally and mechanistically similar to the Delta pH-driven thylakoidal protein import pathway. A functional Tat system or Delta pH-dependent pathway requires three integral membrane proteins: TatA/Tha4, TatB/Hcf106 and TatC/cpTatC. The TatC protein is essential for the function of both pathways. It might be involved in twin-arginine signal peptide recognition, protein translocation and proton translocation. Sequence analysis predicts that TatC contains six transmembrane helices (TMHs), and experimental data confirmed that N- and C-termini of TatC or cpTatC are exposed to the cytoplasmic or stromal face of the membrane. The cytoplasmic N-terminus and the first cytoplasmic loop region of the Escherichia coli TatC protein are essential for protein export. At least two TatC molecules co-exist within each Tat translocon [1].	25.10	25.10	25.20	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.57	0.70	-4.94	144	3911	2009-01-15 18:05:59	2003-04-07 12:59:11	13	4	3551	0	920	2811	2612	213.10	33	80.99	CHANGED	hpH.LpELRpRllhsllulllshh.l....sa.ha.........................spt...........lhp.hl.tpPhtthh........................................................................................................pllhhs..st-sFh.shl+luhhhulhluhPhllaQlWtFlsP.GL.....acpE++hhhhhlhhuslLFhhGshFuYallhPhshpFhhs....ass......................................th...h..........pshhslspYlshlhphhlsFGlsFpl.PllhhhLsp..hGllssphltctR.+asllhhhllAAllTP.PDshophhlulP	...................................................................h.pHLhELRpRLlhsllulllhhl.shh.hF.................................spp.........................lhp..hl..stPl.h.p.t.h.t.t.........................................................................................................................................................................................................................phlsos..lspsFh.s.lKlshhsulhluhPll.lYQlWsFluP..GL.....Ycp....E.+...+h....hh...shlh..so...slLFhhGhsFuYalVhPhshp.Fhhs........hus....................................................................................................................ps.s........pshhslssYlsFlhpl.hh.uF....GlsFE.l...Pl...llh.hLsh..hGllosppLp.ct.R...+asllshFllu.ullTP.PDlhSQhlLAlP..............................	0	296	615	790
+4815	PF01206	TusA	UPF0033; SirA;	Sulfurtransferase TusA	Finn RD, Bateman A, Eberhardt R	anon	Prosite	Family	This family includes the TusA sulfurtransferases [1].	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.07	0.72	-4.37	195	5303	2012-10-01 20:42:06	2003-04-07 12:59:11	12	41	2909	8	1162	3036	759	69.70	28	50.37	CHANGED	tplDspGhtCPhPllcs+cslcph.psG.....phl...p.....llsscssuh.pslspascppGt.pllph..pp...........ps..sta.phhl.cK	............pLDshGhtCPhPllts+cslp....ph.psG......-hL...p..................llsssssuh.psIst.asp.pp.Ga..pllsh.pp...........ss....ssa.phhlpK.....................................	0	395	744	997
+4816	PF02381	MraZ	UPF0040; 	MraZ protein	Bateman A	anon	Bairoch A	Family	This small 70 amino acid domain is found duplicated in a family of bacterial proteins. These proteins may be DNA-binding transcription factors (Pers. comm. A Andreeva & A Murzin).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.18	0.72	-4.22	23	5872	2012-10-01 20:57:08	2003-04-07 12:59:11	13	3	3008	36	1347	3446	3377	70.70	25	92.00	CHANGED	hatGshphplDspGRlhlPupLRpthshp....h.slshGhsspLElastspWcphtpc..tchshsphspRthtch	........................hhtGshphp.l.Ds.p.GRlh...lP......sphRc...t....hs...hp..............t....l..h.l.......h.........G.........h.....p..s.......p.........l.t.lastspW.pp.htpc...tp.hs...p....t.....h...................................................	0	490	935	1179
+4817	PF03650	MPC	UPF0041;	Uncharacterised protein family (UPF0041)	Bateman A	anon	SWISS-PROT	Family	\N	20.50	20.50	20.60	22.40	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.65	0.71	-4.18	6	818	2012-10-03 12:15:12	2003-04-07 12:59:11	8	10	299	0	552	772	7	104.80	35	81.39	CHANGED	hhphth+thWpp.sGPKTVHFWAPshKWGLlhAGluDlKRss-hlSGsQshALluTuuIWTRauhllpP+NYLLuoVNFFltssuusQLsRIs..sYphpssD.hpp...hhhpth.....tucphup	.......................h.........hpt..sh.posHF......WuPl...hp.....WGlslA...ulsD.h...p.+...s.sEh.......ISss..............os................AL..sshu.h.lah..............R..au.hh....lpP+Na...hLhusphhstssthhQhhRhh.....pap...h....t...........................ttt.............................	0	173	292	451
+4818	PF03668	ATP_bind_2	UPF0042; ATP_bind2; 	P-loop ATPase protein family	Bateman A, Yeats C	anon	SWISS-PROT	Family	This family contains an ATP-binding site and could be an ATPase (personal obs:C Yeats).	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.89	0.70	-5.33	4	3506	2012-10-05 12:31:08	2003-04-07 12:59:11	10	6	3441	0	667	2112	733	275.40	43	93.34	CHANGED	hpllIloGhSGAGKoVAl+uLEDhGaYCVDNLPssLLPchs-hht...s+.oplAlshDlRshs.osclhctt.phhpc.thoP+llFL-AccsTLlRRYp-oRR.HPLuucsLsLEu.IstEpchLEPL+u+AsLIlDTSchSs+sLtEplccthtGsptcpholsVESFGFKYGIPlDADhVFDVRFLPNPHWsspLRPhTGh-tsVusal.++sEspcFl.ph+chLshhLPhhc+ps+SYlTIAIGCTGGKHRSVhIAEpLu-YF+uctpssh..pHRsLE+c	............................................pllIloGhSGuGKol.AlpsL........E...DhGaaCVD...N......L....P.ssL....LPc.h.s.c..h...ht.....................t.......s....p........p........c.l.AlslDlR.s..t..s..h.h....s.....p..l.h....ph....lt..p..h..t.s....p.......sh...s..hp.lLFLDAscpsLlpRY.p.-TRRhHPL...u...............s..........p..................s..................h...............h...........l....-........u..Ipt.E....RclLps.L.+stAs..hl.lDTopho......s..+cL+c...p.......lpp..t...h...t...s...p...p..p....p.....p...h....p....l..p....l.SFGF.K.a..G..lP.l.D......A.....D.....hVFDV.R.F.LPNPaa.s.cLR.P....h...TGlDp.sVtsYlhp.ps-sp.pFhpplpsh.Lchh...LPtap.c.-u......+S.............h.LTlAIGCTGGpHRSVhlAEpLuc.hL....p.......p.......c.......t.......p....s.....st......pHR-lt+......................................	1	224	442	572
+4819	PF01985	CRS1_YhbY	UPF0044;	CRS1 / YhbY (CRM) domain	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly.  GFP fused to a single-domain CRM protein from maize localises to the nucleolus, suggesting that an analogous activity may have been retained in plants [4].  A CRM domain containing protein in plant chloroplasts has been shown to function in group I and II intron splicing [5].\	     In vitro experiments with an isolated maize CRM domain have shown it to have RNA binding activity.  These and other results suggest that the CRM domain evolved in the context of ribosome function prior to the divergence of Archaea and Bacteria, that this function has been maintained in extant prokaryotes, and that the domain was recruited to serve as an RNA binding module during the evolution of plant genomes [4].  YhbY has a fold similar to that of the C-terminal domain of translation initiation factor 3 (IF3C), which binds to 16S rRNA in the 30S ribosome [1][2].	20.80	20.80	21.10	21.40	19.60	19.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.49	0.72	-3.98	144	3330	2009-09-11 02:11:35	2003-04-07 12:59:11	16	11	2788	4	855	1854	228	83.80	36	62.62	CHANGED	Lo.scp+chLRuhu+pL..cPl.l...tlG+sGlocullpplcpsLcs+ELlKl+lhp.s..stps....pcphsppls.........pp.ss.upllp....hlGcsllLYR	...............LosKQ+paL+uhAHsL...cPl..l.............lGcsGls-slltplcpAL-.p.+ELIKVclhp..s.....sc..-s........pppls-tls..........................................cp.os.uphVQ.....hI.G.+.h..lVLYR..............................	0	200	497	697
+4820	PF01894	UPF0047		Uncharacterised protein family UPF0047	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.	20.20	20.20	28.00	21.30	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.34	0.71	-4.28	109	2428	2009-01-15 18:05:59	2003-04-07 12:59:11	12	12	2035	22	936	1913	1389	118.70	38	81.59	CHANGED	hcITspl...pphlppo..ulpsGlshlFs..HTTAulslNE.......shDPsVppDltphlscllP......pst..............tYpHsp......................ssusAHl+usLh.GsSlolPlpsGcLhLGTWQuIahsEaDs........s+.pRplhlplh	.........................h.lTccl..pph.s.p...h....s......s.lps.GL..lplhl..HToAuLslNE............NsDP.s.V+pDhpph....hp+l..l.Pcss...................................tY.cHsh.p.Gs................................DchsAHlK.uull.G.sSls.lPl..p.pG+LtLG..........TWQGIaLsEacs........sp.pR+.llspl....................................	0	352	620	800
+4821	PF01458	UPF0051		Uncharacterized protein family (UPF0051)	Bateman A	anon	Prodom_3219 (release 99.1)	Family	\N	20.80	20.80	21.30	20.80	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.03	0.70	-4.91	122	7024	2009-09-11 15:27:28	2003-04-07 12:59:11	12	12	3542	6	1556	4676	4761	229.60	32	51.85	CHANGED	s.sssstts+hllhltcsupss..ll-p.................s.ssssshpssssclh.lscsAplpahp.lpp.......spssh.phsstts..phtp.suphp.thh.shGuphs+tphpspL.tGpsupsplpulhh.spsppphDhpstlpHtu.p.spop.hh+ullpc.....pu..cslFpGhlplppsA.pposup.pscsLlL.ocpAcssohPpLEIhsDDV.csuHuAol.GplDc-pLFYLpoRGlscpcApplllpu.F	..........................................................................s.thstapRsllls--supls..alEs..................ssshtsss.sh..puulV...El.h.ltc.sApl+...ass.lpsh..........upssh....sh....ss.+R.u.....hs.t.c.suphp..Wsps..ph.G.u.tl..o..h..ph..ssshL..pG-supuchholuh.ss.s...p...Q...p.....t.Ds.ss+hhHhu.p.Tp.SpIlpKul.sps................p.u.ps.sapGhlpltpsA.ptu.c..........up.pscsLll..s..cpupu.-ThPhl-I.......c.ss...sl.ph.pHtAol.u+ls--QLFYLhSRGlscc-ApphlVpGF......................................	0	534	1049	1341
+4822	PF01933	UPF0052		Uncharacterised protein family UPF0052	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	\N	21.00	21.00	23.00	22.80	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.02	0.70	-5.10	32	3153	2009-09-11 09:44:17	2003-04-07 12:59:11	13	5	2883	21	736	1931	763	296.60	33	87.30	CHANGED	lVslGGGTGLuplLpGL+ph.................ssclTAIVTVuDDGGSoGcLRcths.hlsPGDlRsslhsL.u-.....pphhtplhpaRFp.....................................................ssstLpGHshGNLhLsuhpphtsshtcAlphhuplLtlcG..+llPh..opcslsLtAchp.....sG.........phlhGEspIsp...................................................ttthlcclhlp.........sppspss.cul-AIp-ADhIllGPGShaTSllP.LllssIscAlpcop.A.hlhlsNlhsp.G.Es......sthsssc+lcshtptsucthhDhlllsspt.sstp.tpphhpcssp.sphsttthcphshphhtsphlttt	...............................................................................................lVslGGGpGLu.hlLpuL+ph........................................ssclTAIVTluDsGGSoGclRcph.s.hl....sP...GDl.RNsLs...uL.......o-....................sphhpp..l.FpY.RFs..............................................................................ssupLuGHslGN......L.hls.u.l.........s.p.h..p.s.s...........h.h.....pA....l....p.hlsplLplcG.....+llPh.....o.p.p.slsLp..Ahhp................sG..................phlh...GE..s..pIsp............................................................................................................................................hps..hlcclhlp.......................................spstAspcs.l.....cA.....IpcA....D..h...IllGPG.ShaTSllPsLll.....sp.lucAl....t.......c........o........p...A.............hlYl.sNlhsp..G.ET.............ssho.stc+l....cslppa.....l....u.....p........hl...D....s....V..l...l..ss..p.......s.....p.t...h.t.p.t.hh...p.c..h...h..s...p.h.sh.t...t....pp..hpsh.......ht..............................................................................................	0	227	481	642
+4823	PF02130	UPF0054		Uncharacterized protein family UPF0054	Mian N, Bateman A	anon	IPR002036	Family	\N	25.00	25.00	27.50	26.30	23.70	24.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.90	0.71	-4.91	159	4595	2009-01-15 18:05:59	2003-04-07 12:59:11	12	13	4493	7	1042	2973	2301	142.80	31	85.81	CHANGED	l..phppptths..................th..lpthhphhttpht.................lslhhsscpplppLNppaRs+DtsTDVLSF.shppsst....................................................LGDIlluh-tstcpAtc.hs.+s..hpcclsaLhlHGhLHLl..G..YDHp.p.p...p-tptMcthEpplLppls	.......................................h.tp............................hpphlphsht.p.thttt.............ElolthVDspchppLNtpYR.scD...........pPTDVLSF..shcp.tth.t.h.........................................................................LGDll..Ishphspc..p.........ApEhG..+o................hccchuaLs............lHGhLHLLG....YDHh..p..s......-EtccM.uhppcILpth.t....................	0	363	685	878
+4824	PF01679	Pmp3	UPF0057;	Proteolipid membrane potential modulator	Bateman A	anon	Pfam-B_2192 (release 4.1)	Family	Pmp3 is an evolutionarily conserved proteolipid in the plasma membrane which, in S. pombe, is transcriptionally regulated by the Spc1 stress MAPK (mitogen-activated protein kinases) pathway. It functions to modulate the membrane potential, particularly to resist high cellular cation concentration. In eukaryotic organisms, stress-activated mitogen-activated protein kinases play crucial roles in transmitting environmental signals that will regulate gene expression for allowing the cell to adapt to cellular stress. Pmp3-like proteins are highly conserved in bacteria, yeast, nematode and plants.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.53	0.72	-4.26	117	1655	2009-01-15 18:05:59	2003-04-07 12:59:11	12	10	1131	0	687	1065	84	50.50	45	65.92	CHANGED	tcl..l.hlllAIl....LPPluVal..ctG.hutch..hINllLTlLG.a....lP........GllHAlallhp	.............................t..hhcllluIl....LPPLGVhl....tpG..h...GhsF.....lINILL..TL..LG.Y...................lP..............GlIHAhalh....................	1	179	378	588
+4825	PF01893	UPF0058		Uncharacterised protein family UPF0058	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This archaebacterial protein has no known function.	25.00	25.00	40.60	40.50	24.10	19.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.00	0.72	-3.93	23	129	2009-01-15 18:05:59	2003-04-07 12:59:11	11	1	72	2	82	129	5	85.20	36	91.95	CHANGED	MH....K-ELlpLHphhspl++ahc.......ppsssptFcpY-pLcIsPsHlH+oKsEHKaAIFlLusslAphhu.pc-ts.spplup+h+-hA-csh+	......M+K-ELlcLHphLsplpchhcp......ppssst.hcpYcpLslpPsaIHKoKsEHKtAlFlLussluphhu.pc.cts.stphstthtp.s.p...t..................	0	13	54	73
+4826	PF02694	UPF0060		Uncharacterised BCR, YnfA/UPF0060 family	Mian N, Bateman A	anon	COG1742	Family	\N	22.30	22.30	22.50	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.62	0.72	-4.03	4	1396	2012-10-02 19:55:49	2003-04-07 12:59:11	10	3	1342	0	296	828	194	106.10	50	96.41	CHANGED	hl+olLLFlhAuLsEIGGuaLVWLWlREs+uhhhulsuuIhLsVYGalsTLQP.AsFGRVYAAYGGVFlshulhWGhhVDshpsDhaDWlGAhIsLsGVhVIhaAs.Ru	....................................hl+ohhLFhlsALsEIhG.C.aLsW.L.WL+c.s..tShahllPuuloLuLFsaLLT.LpP..uu...u.........GRVYAAYGGVYlssuL.hWLhlVDG..h+.shaDhhGAlIsLsGhhlIlhu..R.............................	1	88	179	236
+4827	PF02696	UPF0061		Uncharacterized ACR, YdiU/UPF0061 family	Mian N, Bateman A	anon	COG0397	Family	\N	19.90	19.90	20.10	19.90	19.60	19.80	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.86	0.70	-6.20	3	2147	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	1912	0	684	1870	2381	431.40	40	89.41	CHANGED	soLSslTcths.lspsYsAhDPVsLshF.ssRLla+Ns+LAssLu.....hcPSpLpcNuhsEh..V.st..EuLLsG.......shsPLApVYSGaQFGsaAuQLGDGRGlLLG-.hLsDGsohDWp...LKGAGhTPYSRhGDGRAVLRSoIREsLASEALHpLGIPTTRALSLVpossShspR-ssEP..uAVlhRFAPSHIRFGsFE+F+YRH-oEpltQLuDasIccYau......................Esph..pluDDE........D......KYctFFRcVVuRsAsLVAQWQAsGFAHGVLNTDNMSIhGLTlDYGPFGFLDcYEPuFIsNHsDauGRYSFuNQPAVshWNLQRLApoLSsllus-A..........LN...EALEc................YcpVaLT+YuplMuQRLGls.sLtcpMo.......Ep.....KEhs-sLVspLLslLApo+sDYscFFtpLp......Focs+SDsAsLhht.DE.....Flsu......A-a--WFAth.....hpG.......+LQ......QDhLppVPPoEhAARsoLhcpANPLhVLRsWllEcVl-...Aup+DG........DhosL++LaptLpNPa	...........................................................................................................................................sspll.h.hs.p...t.lA.t.tLu............s.t..h......p..t.t.h.h...........huG......ppl.h....sG.....................................h.p.PlAp...sY.u.G......H..Q......FG.s.......a..ss.....pLG.DGRulL..L..G..E......h.........t....s.....s............G.....p.........p....hD.hp...................LKG....uGhTPY............S.R..h......G....D.....GRAVLRSslREaLsSE..................AMa.t.L.GIPTTR..ALul....lso.s.....p.......sV..h......R..............E........p..........h..........-...s..............GAllhRlAsS.HlRhGpFE....a...a..............h..............h.....p...............t...........p.....................-.......p..............l......+.p........LAD..a....s...I.c.+...aa.P.............................................................................................th.t.ssp...........................p..............tY.hth....hppV...sp....RsApLlApWQsVGFsHGVMNTDNMS.IhG.TlDYGPauFhD.........s.......a-PsalsNp...sD....p.p.G.RYuasNQPsluhWNLt....+LApsL..h..P..l..l...s.......-..t...............................lp.......p.u...L..s.p...................................................................ap.ph.......h.....s...pa....t....p.t....M....c...pKL...Gl................hs...........................p-...Dp...t...Ll..spLh.plM..tp.....pp.s..DYTp.hF...RtLu....................................t..p.t....t....s...s...s..s..l...h............t.t.....................hh.s.p....................................................sta..c.t.Whtta.........tt..........................Rlt.........................pc...................t.s....t.....p.................p.tph..Mp......ps.NPthl.RNalsppAIc...tApp.G...........Dh..s.lccLhpsLppPa..................................................................................................	0	200	396	551
+4828	PF03401	TctC	UPF0065; Bug;	Tripartite tricarboxylate transporter family receptor	Mifsud W	anon	Pfam-B_3343 (release 6.6)	Family	These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria [1].  This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [3]. The TctABC system has been characterised in S. typhimurium [2], and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria [2].	21.20	21.20	21.20	21.50	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.38	0.70	-5.47	9	6762	2012-10-03 15:33:52	2003-04-07 12:59:11	9	22	1130	7	2903	6666	2997	269.60	28	83.24	CHANGED	lARhluppMucpLGQPVlV-N+sGAGG.IuushVApuAsDGYTlhl.susuh.slssahYsplsYcsh+DhsPVs.lsssPhVLVVsusSshpslp-LlshA+ssPsKLoaASsGhGoosHLsuElhpucsGsphhHVPYKGuuPAlpDLluG+VDh.MhsslsostshIpus+lRALAVsotpRpstLP-VPTlAEsG.ltGh-shsWaGhhAPpGTPssVlp+LssAhppAhpsPtlhcthpshGhpsh...ssoPpphsphhpuEspRWutLIpchGl	............................................................................ARhlupt.h..s..p..t..L....G...p..s..l.l.V..-N......+.s.G.A.u.G..slG.s..s.t.l.u..c.u.s..s...D..G.Y.Tl.hh....s.s..s.uh....sl....ss...t...l...h...t...p...l...s...a..c......s...hc.D.h..s.P.l.u.h...l.u...p.s.s.h.l.l...l..V.s......s....s....s....P....h....c....o.lp-l...ls..h..u..K.s...p...P...u..p...l.s.a..u...o..u.G...s...G.o.s.s....H....L..s....s.t...h....h....t.p......t.s...G....l......c......h....p....a.......V...P...Y...+....G...u..u...s.A..ls.sll...u...G..plsh.....hh........s...s........h.s.s.....s....h....s.....h.....l.......c......u.G..+..l+.s.L...A......V..s.......u...s.....p.........R.........h.........s.........t...........l.........P.........-.....V..PT........h........s.E.t...............G.....h.......s.........h...p....h.....s.....s.......W....h...........G........l........h.....u...........P..........s.us...P...s...sllpcLssslp.p..sl.p.s..s.p.h..p.......p..p.h.p.p.h..G..h...p...s.h......st.s...s..p.ph..s.p...h...lpp-...htca.tpllct.t.h...........................................................................	0	403	1505	2405
+4829	PF01980	UPF0066		Uncharacterised protein family UPF0066	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	\N	21.40	21.40	21.40	22.60	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.58	0.71	-4.15	184	2012	2009-01-15 18:05:59	2003-04-07 12:59:11	11	13	1761	6	580	1490	102	122.50	43	54.57	CHANGED	p+hssP+Q.sth..............sspuplclhspa....tpuLpGLEpaSHlhllahhHcs..................................hhp.P+h.t.......ss.tphGVFATRSPtRP...NPIGlSlVcLh..plcssp.....LtlpGlDh....................lDGTPllDIKP.Yls...hh.Ds	...............................................KhuhPRQ...sslsp......sspuplcLh.s.a..........ts-ulcGLEs..F..SHlWllFhFHps.............................................................................p...shcsp.V.R..P.PRL..s........Gst+hGVFATRSsaRP...NPIGhSlVcLc..plc..spp....................Lplu.ulDL....................lDGTPllDIKPYlPas..p...........................................	0	215	365	478
+4830	PF03006	HlyIII	UPF0073; 	Haemolysin-III related	Bateman A	anon	Pfam-B_1581 (release 6.4)	Family	Members of this family are integral membrane proteins.  This family includes a protein with hemolytic activity from Bacillus cereus [1]. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism [2]. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins [3]. The mammalian members include progesterone binding proteins [4]. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.	26.20	26.20	26.50	26.50	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.93	0.70	-4.94	81	4985	2009-01-15 18:05:59	2003-04-07 12:59:11	15	18	3463	0	1622	3448	460	203.00	27	78.87	CHANGED	ashppEhsNshTHhlGslhshhsh....hhlhshuthtt....s.ht...........................................................................hlshslashuhhhhhhsSslaHt...hsptc..................scthhppl.D+suIalhIAGo....YsPhhhhsh.....................................p.s.hs.hhhhsh....lWs.hulhGllhphhhh.........................tph..+hlpshhY....lshGahslhslhth..hhthsshs........lhhlhhGGlhYslGul.FYuh+.........................................................h...a.....tHtIaH..lFVlhuuhsHa	................................................................................................................................................htpEhsNshoHh........l.G.hlhs.l..h..sh....s.h..l.....h.h.h.u.s..tt............shht.....................................................................................................................................................................................hhu.h.slas...huhhhha.h.sSolYHs.h......h...st...p..................s+th.hp.th.DHsuI..alhIA....Go.......YTPh..hlhs.h.............................................p...s.........h.u.....h........hl..h...h.l.........................lW.s...h.u.lh.Gllh..c.h.hhh................................pph....+hl.sh......s..h..Y....lsM...GW.hs.l...hslhth......hht.....hss.hs.......................hhhlhh.G.GlhY...ol...Gsl...FYst.+...........................................................................................................................................h.......a...............tHtIaHlFVlsuuhhHa................................................................	0	475	832	1230
+4831	PF02082	Rrf2	UPF0074; 	Transcriptional regulator	Mian N, Bateman A, Yeats C	anon	IPR000944	Family	This family is related to Pfam:PF001022 and other transcription regulation families (personal obs: Yeats C).	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.41	0.72	-3.86	118	8068	2012-10-04 14:01:12	2003-04-07 12:59:11	15	22	3692	17	1984	8534	1782	81.20	29	53.34	CHANGED	Mp.lospscYul+sLlhL...At.ptspt....lsspplAp..pt.sls.saLp+lltpLpcsGllcShRGstGGapLA+sspcIolt-llcul	.......................................Mp.loscscYul+.sl.lhl................Ah.....p..s...p....t..t................loh.p.plAc..p..sl.s..saLcplhspL..p+..s.G..l..l..p..o...h......R...G.s.t....G.G.a..p.L....u.+.s.s.pc.Iols-llcs................................	0	686	1302	1664
+4832	PF03702	UPF0075		Uncharacterised protein family (UPF0075)	Bateman A	anon	SWISS-PROT	Family	The proteins is this family are about 370 amino acids long and have no known function.	20.40	20.40	20.40	20.40	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.13	0.70	-5.56	9	2041	2012-10-02 23:34:14	2003-04-07 12:59:11	9	6	1964	6	505	1648	2620	357.50	42	96.82	CHANGED	.hYIGlMSGTSlDGlDhsLlchst...scspLltuchh.PhPssLRpplhsLpps.sssoLpphGpL-pplGhLaucslsphLpppplpsspIpAIGsHGQTlhHpPs.uphPFThQlGDssllApcTGIssVuDFRR+DlAhGGQGAPLVPAFHpAlFtssspspsVLNIGGIuNlSlLhPstsVhGaDTGPGNsLhDAWhp+aps..tsaD+sGtaAupGpVstsLLspLLs-PaFuhPuPKSTGREhFNLsWLpcpLtpt..............spDVQATLsELTApoIs-ultpttss.spcLlVCGGGA+NslLMtRLuthLPs.hpVsoTsphGlssDhhEAhAFAWLAapplssLPGNlPuVTGApphshLGAIaPs	..........................t.hhIGlMSGTSLDG.lDssLsphct....................pp..l...t..h....l....u....s..h..s..........h.....Ph.s.......ss...........L.+.......ptl......h......s.....l......p.p......s.......p..................p......t......s...l........p......p......h...u..pL...-........pp............L.u.p.haApAVp.tLLp.....p...ps..l...p.s.pcI.sAI.GsHGQTVhH..p...P...................p......s............................h..........s...............a..........Tl.QIGD.sshlAtp....T...GIsVVuDFRp.+DlAh..........GGQ.GAPLVPAFHpuL....h.......s.......c............s....s......c.......p......R.......h...l......LNIGG..IANlol........L.............................s....................s.......p.......s...............l.........h.......G..a.....DT.GP.GNhLhDu...Wh..t..+.p.t..u......................psYDcsGpa.A.tpG..p..V......sL..L.p.p.....h......L..s.....-..P.YFstssPK.STGRE.hF....s....hs....W...Lp..p..p..Lp..phst....s...................spD.....l.tATLsc...l.......T....A....hoI.......u....cp....l....t.............t.........h............s.....s............s.......c..................clhV..CGGGu+NshLMtcLtsh.L.........s..................s.......hp.....V.p...oo.-.s....h..G.....l.s...u.....Dth.E.............AhAF.AWLAh.csl.t.Gl..PuNlPuV.....TGAsp..slLGsla..h..............................	0	141	308	416
+4833	PF02367	UPF0079		Uncharacterised P-loop hydrolase UPF0079	Bateman A	anon	PSI-BLAST P31805	Family	This uncharacterised family contains a P-loop.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.79	0.71	-4.49	14	4392	2012-10-05 12:31:08	2003-04-07 12:59:11	12	12	4337	6	946	3129	2397	122.70	35	71.63	CHANGED	ThplGpplup.L.....psGsVllLpGDLGAGKTshs+Glupul.Glpt..tlsSPTFsLlp.Yp....sshhlhHhDlYRLtsh-.hphh.....t.h-h.hs.-ullslEWuEthsp..Lspppl..plplchhspucpph	.................................h.tlupplu...ph.h........p.su...s...l...lhLpGDLGAGKTTho+.Glsc....u.L....Ghpt........sV.p.SPT...a...o....ll.c...p....Yp......................sp.h..s.l..a..Hh..DlYRLs.cs.c.E.h.tth............................Ghc-a.h....hs.suls.llEWs.p.t.h.ts....hL...P...s....s.p...l...plplphtspsp...hh................................................................................	1	332	637	811
+4835	PF03652	UPF0081		Uncharacterised protein family (UPF0081)	Bateman A	anon	SWISS-PROT	Family	\N	29.20	29.20	29.20	29.60	29.10	28.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.52	0.71	-4.05	174	4409	2009-01-15 18:05:59	2003-04-07 12:59:11	10	7	4296	8	962	2703	2115	133.70	34	91.91	CHANGED	tplLulDhGp+RIGlAlu-shthh.Apslpslp.pp.............tshppltpllpch......p..ss.tlVlGlP.........hsh.s.Gststtspts.ccFuppLppph.........sl...s.lhhhDERhoohtAp.phl..h.t.......tsh.pp.....pc++p...hlDphAAslILpsaL-p	.............................plLulDhGoKplGVAluD..hs.hh.Aps.Lpslp...sppt.............p..shspl.tcllcca.......p..ss....tlVVGLP.......................hsM....s.Go.p.us.t.sp.ps.cpFup.pLpp.ph.............sl.....s.VthhDERLoTstAc..ptL...h...p..........................tsh..p+............pc++p.....hlDphAAsl..ILpsaL-....................................................	0	324	638	820
+4836	PF01868	UPF0086	DUF49;	Domain of unknown function UPF0086	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease P protein subunit p29 proteins.	21.00	21.00	21.00	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.76	0.72	-4.34	36	446	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	413	9	311	441	62	88.50	28	44.89	CHANGED	hlsspNllp....HELlGLclcVlpopssshlGlcGhVlcET+solhltTpcs...tplPKctslFpFplsstp............................VclcGshLhuR.PEcRlc++	..............h....tpLhp....t-hpGshlpVscSps...suhlGlpGIVlpETcpshhl........l......s.cc...s.....p......h..............+.h..........lPKpsslFp..hplss.t..............................................................................................hplhGpph.hRstcRht+.............................	0	99	173	254
+4837	PF03007	WES_acyltransf	UPF0089;	Wax ester synthase-like Acyl-CoA acyltransferase domain	Bateman A, Auchincloss A	anon	Pfam-B_1896 (release 6.4)	Domain	This domain is found in wax ester synthase genes such as Swiss:Q8GGG1. In these proteins this domain catalyses the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters [1].	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.70	0.70	-4.83	16	1646	2012-10-02 12:01:53	2003-04-07 12:59:11	11	16	348	0	475	1277	107	248.90	24	54.16	CHANGED	LushDuhFLhhEsssp.hHlGtlslhchs.tsss........hcchtsshtpptphhPhh+p+.hsh.hshststWhsDschDlsaHVRRsALPuPGshcELh-LlucLtupsLDRsRPLWEsallEG.LssGRhAlhhKhHHAlsDGVuuhplhtphhstsPcssshsss.p.ssss....psphpttu....................hshsptltthssulsGsspssschhttsh.........spssshshsss......poshN.sslutpR....RhustplsLscl+tVscthGsTlNDVs	.......................................................................................hsshDthalhhE..s..sp..t.....h.H.sutl.hhhp.s......sss.......................hcp.h.h.pt.h.t.p.....p...h.t.hh..P.h.h.c....p.+....h...........h..s.h...s.t.....s.hW..h.p..-s...p.hD..lshHl....R.....+....s....u.L....P......s....P.....G...s......h....c...........-.....L.....h..c.hl.....uc..l.t..up..L.D.+..s.R..PLWEh.....a.l......l....E........G......L...........s......s............s..............R......h......A............l..h.hKhHHulsDGlu.u.hp.lh...tph.h....s.....t.s...s......s..s..s...h..s..s.......h...t...ssts.........tttht..s..................................................................ht...h.hp.t..l..t....t....h......s..s..s..l...t.......s....h....s......p...s.s..h.p.hhttsh................st...p...h..s..h...s....h...s...s.s......................to..h....N....s..s.l...s...s...tR......................+.h..u.s...t.p.hsLscl+tlt.p...t..h.......s...solNDVh............................................................................................................................................................	0	129	319	422
+4838	PF03653	UPF0093		Uncharacterised protein family (UPF0093)	Bateman A	anon	SWISS-PROT	Family	\N	24.50	24.50	24.60	25.00	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.15	0.71	-4.25	64	1256	2012-10-01 21:57:53	2003-04-07 12:59:11	8	1	1156	0	386	1034	1528	142.40	37	93.54	CHANGED	h..shY.WlKuhHlluVluWMAGLFYLPRLaVYHs-st.sts.ptpphFp....hMEc+Lh+hIhsPAMlsohlhG.lh.lshts....uhh.hs..sWh+s.KlshVllhshaHhhhsthtKchttspsphos+haRhhNElPTlLhllIVlhVllKP....F	...........h...hahWl...KuhHllulluWh..AGLFYLPRL..FVYHupsp.ss...s...........t....p.pphp.....lME++La+.hIhs.PuhlsollhG.hh...Lh.ht.........thhh..h.st..GWhHs..K.....LshVlLLlsa.Hh.h..s..u..t...hh...+phtp.sp....s.p..+.S.t.+.aa..Rh.hN..ElPsll...h...l.s.IVlLVllKPF.....................................................	0	107	248	316
+4839	PF02016	Peptidase_S66	UPF0094; Peptidase_U61; 	LD-carboxypeptidase	Bateman A, Studholme DJ	anon	SwissProt	Family	Muramoyl-tetrapeptide carboxypeptidase hydrolyses a peptide bond between a di-basic amino acid and the C-terminal D-alanine in the tetrapeptide moiety in peptidoglycan. This cleaves the bond between an L- and a D-amino acid.\	      The function of this activity is in murein recycling. This family also includes the microcin c7 self-immunity protein Swiss:Q47511. This family corresponds to Merops family S66.	19.70	19.70	19.70	20.10	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.71	0.70	-5.46	167	2826	2009-09-11 05:12:09	2003-04-07 12:59:11	10	10	2139	40	547	2166	479	284.20	28	90.74	CHANGED	lulluPS....sshpp.p..ph..ppulphLc.shGhplhhuppshpp..ht.....hh...uussppRsp-LpphhpDsslc..uIhsspGGaGusRlLshlD...as.....hl...ppp........PK..hhlGaSDlTsLthslhtps.Ghso..hHGPh.....hss.ht........t..................sshohpphtph...Lhs.............................t.ths.sssththhtsG..........pspGpLlGGNLsll.............spLhGTsa.hs....................phcs.......tILalE-lsEt....sacl-RhLtpLphuGhhcplpGlllGchsth.........s.t.stslpcllpchh..tths.....lPllhshshGHst.sph.....slPlGspspl..s	...............................ltlluPS........sthpt...p...th...ptulppLp....shG......hplh...s..pthhcp............t...hh.....uu.os.ppRhpDLp........phh..p..s..s..s..l..c...hlhssh.G.GasusRLLsh.lD......ap.......tl.......pps.........PK.....lhhGaSDhTulptulhtps...slh.T..aaGPh..hssths..........t.................sshohppahph.....lps..................................................................thssth.th.hs.ss......................pspG.plhGGNLshL..............t.tlh.G.T.sa..hP............................phcs.......tILhLE.-.s.sEp........shcl-R...hLhpLtt....s.G.lhsphpulllGpaptt....................s.stsh..sh.pp.ll.tphh.....tphs..................lPllhshshGHsp.s.p.h.....slPlGspupl................................................	0	184	356	461
+4840	PF01981	PTH2	DUF119;UPF0099; Pep-tRNA_hydrol; 	Peptidyl-tRNA hydrolase PTH2	Enright A, Ouzounis C, Bateman A, Mistry J, Wood V	anon	Enright A	Family	Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation.	21.10	21.10	21.90	21.20	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.37	0.71	-4.39	69	1006	2012-10-02 19:40:38	2003-04-07 12:59:11	11	13	703	22	562	916	123	109.50	31	60.74	CHANGED	phKhllVVRsDL+MuKGKlAAQsuHAulushhph.........hpts...............................phlcpWh.ppGQtKlVL+sp..spccLhcltppAcphGlsstlIpDAG+TQls.PGohTlLulGPuspphlDclTGcLKLL	.............................................t.hlllR....s....D....L........p.....M....s........p.........GKlAAQ.su...HAulsshpth............ppp..s..t.........................................phlc.p.Wc...p..s...G..ptKlV..lcs.t........s.p..p....phh.......p...L...t.......t.p.Ap.p....h.....sl....s....st.....l.lpD........A................G..hT...p........l....s....s.......u.........o..h.....T..slul....tPsstp.lsph..stpL+Lh.....................................	1	194	334	470
+4841	PF02021	UPF0102		Uncharacterised protein family UPF0102	Bateman A	anon	SwissProt	Family	The function of this family is unknown.	21.20	21.20	21.20	21.30	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.07	0.72	-4.06	8	3091	2012-10-11 20:44:43	2003-04-07 12:59:11	12	8	3030	1	769	2274	378	92.40	35	72.54	CHANGED	tuEshAscaLcopGhpllsRNaRs.phGEIDlIApc..scplVFVEV+sRsussassh.htuVT.+KtcKlhcTAppaLApps..hpssssRhDVlsVh	.........................h.uEphA.tpaLp.p.p.Ghplls..pNa+......s......+..........h........G....EIDlIhcc.............sp.......s......l...V............FVEV+h...R...p.....s.....s..t.....aG.s...............s...t...tu.Vo..hpKpc+lhp.sAp.ha...L...t...p..ps......ht...s..s.....s.....s..RFDllul.t..............................................	0	263	523	664
+4842	PF01875	Memo	DUF52; UPF0103; 	Memo-like protein	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family contains members from all branches of life.  The molecular function of this protein is unknown, but Memo (mediator of ErbB2-driven cell motility) a human protein is included in this family [1]. It has been suggested that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [1].	19.90	19.90	19.90	20.00	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.79	0.70	-5.53	11	840	2012-10-01 19:17:44	2003-04-07 12:59:11	12	10	707	8	506	901	112	265.40	28	88.15	CHANGED	.PulAGsaYspssccLpphlc.hhhcshs.t.......tRtlhs.......PHAGYhYSG.sAupuYptLsp....s..-pllIlGPsHsshs.sslulhs.utacTPLGslcVDp-hscpLhpppth......hs.--hsc.htEHSlElQLPFLpahhtc.......hKIVPlhluhps.EsstplGchlscsl+-.s...slllsSSDhsHau.....................................Ppclspph...DchhIctItph....s.cshhphlpphssT.lCGhsPlhlhl.hh+phs......pcuclLcYusSu-lstspsSsVuYAuhl	..............................................................................................sshAGtaYsss.tp.Lpppl.p...th...h..t....p.s..h..t..tt...........................s+sl.ls................PHAGYhYSG.sAAhuY.tt............ls..........sthc.....plhlLGPuHps....hh...p......s....su.l..s.s.......h.......sta.pTP.L.....G.........s.........l.........tl.........D...pchh....p.pLhp..p....t.h...............................hph.....s....ptsc..pp.....E..HSlEhpLPalpphhpp...............h.pl.lPlh.......lG...........t...........h.s............p....h......t....t....p.h....u....phl..sph......h...t..c.p..........slhllSSDhs.H..a..t.....................................................................................st...th.t.pp.h.....D.p..hs...h...........p.....tltph................c.pthh......p..h..l.p..p.....h..t.o..hCG.htPlsshlth.h..pth.t........................hp..h...phlpYtpSu...p.s.p........s.....p.s.p...sVuYuuh.h............................................................................	0	198	336	436
+4843	PF03706	UPF0104		Uncharacterised protein family (UPF0104)	Bateman A	anon	SWISS-PROT	Family	This family of proteins are integral membrane proteins.  These proteins are uncharacterised but contain a conserved PG motif. Some members of this family are annotated as dolichol-P-glucose synthetase and contain a Pfam:PF00535 domain.	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.32	0.70	-5.14	128	4592	2009-09-13 19:27:26	2003-04-07 12:59:11	8	18	2804	0	1355	3742	1049	287.10	16	61.23	CHANGED	shhhlh......hlhtthshpplh.............................ptlt...phshhh........lhhu..hh....lshhs..........................................hhl..puh+...........Wphllpt........ht...............plshhps.h...thhhhuhh....hsh...l.hP..uphG............-sh+shhLp................ppulsh.....spuhss.h........lhpp..lhsh....hslhhhshhshhh.............hh..shhhhhhhh...............hhshhhsshhhhhhhlhth................................h.h.hhht+ltptht.phtpshpt........................h.t...h...hhhh.hhohhhahhthh.thahlhtuhu.hsh........shhhhhhhhshshlss....hlP......sPGG..hGshEsshshhhs.....hhGhssstu.....hsh........sllh+hlshhhsh......h...................hGh	.............................................................................................................................h....hh.....hhht...t...h...s.ht.plh.............................p.slp.........phs.hhh.............llhu.....hh....hshls......................................hhh.......sh.t..h.p.h.lhpt..............hth..........................clsht...ps....h....hsshhs.h..hst...h..hs...sh..s.G......tsh+hhhhp.....................pt.ulsh.....spsssh....h.........lhtt......hhsh......lslh.h..hs.hlhhhh.............................h..h...h.ht.hh.h...hh........................h..hs..h.s..l.hhh..l....h.hh...hhhhth...........................................................................................h.h..p.h...t..p..h......h..t....p..htt.t.htt..............................h.........hhhh.hhhohlpahsh.sh....hha.h.l..h....h.h.hs.hss..............shhth.h.s.h...h..h.l.u.tlsu.....hls....hhP.GG.lGs...hEsshlhhhs.........hhs.l.s..t.s..ts..........lss..................hLlaRlhhahlsh..hlu...............................................................	0	455	894	1153
+4844	PF03656	Pam16	UPF0108; 	Pam16	Bateman A, Wood V, Studholme DJ, Mistry J	anon	SWISS-PROT	Family	The Pam16 protein (Swiss:P42949) is the fifth essential subunit of the pre-sequence translocase-associated protein import motor (PAM) [1].  In Saccharomyces cerevisiae, Pam16 is required for preprotein translocation into the matrix, but not for protein insertion into the inner membrane [1].  Pam16 has a degenerate J domain.  J-domain proteins play important regulatory roles as co-chaperones, recruiting Hsp70 partners and accelerating the ATP-hydrolysis step of the chaperone cycle [2].  Pam16's J-like domain strongly interacts with Pam18's J domain, leading to a productive interaction of Pam18 with mtHsp70 at the mitochondria import channel [3].  Pam18 stimulates the ATPase activity of mtHsp70.	29.10	29.10	29.10	29.20	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.58	0.71	-4.34	3	354	2012-10-01 22:35:57	2003-04-07 12:59:11	8	8	266	8	259	368	4	119.10	36	83.90	CHANGED	MA+RsAlQVIlsGsQVVGKAFARAlRQEh.....AAuRsAAuAtssAS+.RusAsSNhu.GISL-ESpQILNVcc...sLNhEEVpK+YEHLFcVNDKSKGGSFYLQSKVaRAKERLDEEL.+IctKE-KcKupsA+T	..................................................MAthlh.plllhGupllGRAFscAh+Qth..........t..uu...p...t..s....s...t...u...t...t..p..u....st.....ts..s...s.t..s......s...h......p.....G..........hoL..cEAppILN.Vpc.........ths..hEc.lt...c..........+ac+LFcsN......-.....p...p..p.......G...GSFYLQSK........VhRAKERL-.......tEl....p.......t.t.p...............t.t.........................	0	84	143	214
+4845	PF03657	UPF0113		Uncharacterised protein family (UPF0113)	Bateman A	anon	SWISS-PROT	Family	\N	22.70	22.70	22.70	22.70	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-4.58	4	344	2012-10-02 17:37:24	2003-04-07 12:59:11	8	3	328	4	256	328	3	168.10	36	92.25	CHANGED	h+lRpssstEhcLIcctLptYG.ts..alpphth.shtGch+-VasVshslhcslc...Lp.apsGhplGs..hsEhth+hphsLtthhhllpsohN.hshls.+uEhLFLYGRDlatcultchsthGp...lhlhNc.s-hlGIG............hpDthhlKNL+DhG.YLR+	...................................................................R.hpt.E.p.hh...t.h.t...h...h.........h.........................................c....h.......p.p........c...RVYYVs-pl...h.+...h...As....s..........c...........pL..h...S......hGsClGK..Fo.K..........p..s...K..FRL..H..I..T..AL.s..h..LA.aA.+a.KlWlKPsuEhsFLYGNcVlKut...l..GRh...o....E.s...s.s.pat..GVVV..a..o..MsD...lP.LGFGhsu.....ttps.t.p.hp.s..s...s..h..l.l.h.p...............u.......DlGEYLR........................................	0	87	139	208
+4846	PF03350	UPF0114		Uncharacterized protein family, UPF0114	Mifsud W, Vella Briffa B, Bateman A	anon	Pfam-B_3587 (release 6.5) & Pfam-B_10597 (release 10.0)	Family	\N	21.50	21.50	23.40	23.00	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.59	0.71	-4.20	30	1494	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1367	0	351	823	291	119.80	42	68.01	CHANGED	llasoRalhl.hhlGlllutlshhlphhhplhchl..........sphtph............sc.spllLsllslIDlhLluslLlhlshGhYEhFlS+lshtpp...................-pPcWLshhshssLKhKLutsIlsI.ulphLcpah	....................................hauSRWLhsPlYhGL.luhlsLs..l+Fh.pElhHll.............sslh.sh.............................sE..s-l.l.Ls.lLuLl..DhsLlusLLlMVhhuGYEsFVSpL-.lscpp......................-c.pWLu+hssssLKsKlAtSIVuISSIHLL+sFh............................	0	68	180	274
+4847	PF01594	UPF0118	DUF20; 	Domain of unknown function DUF20	Bashton M, Bateman A	anon	Pfam-B_495 (release 4.1)	Family	This transmembrane region is found in putative permeases and  predicted transmembrane proteins it has no known function. It is not clear what source suggested that these proteins may be permeases and this information should be treated with caution.	27.20	27.20	27.20	27.20	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-11.86	0.70	-5.45	32	12059	2009-09-10 15:51:07	2003-04-07 12:59:11	11	19	4455	0	2730	8340	2223	323.20	19	87.74	CHANGED	hhhhhhhhlhhhshhhhhs....lhhshlluhlluhlhpslhphL.ppttht+hlulhllhlhhlshhshhhhhlhs.hhsphtpllpslP............phhsthtshltplttph.hh............t.ht.thsphlsphhspl.....hstlhshhtthsthhlphlhhllhhhahLhctcphhphlhphhPtph+pphpthhpphppt...ltsalhuphlhullhulhshluhhlhsl...aullhullsslhs.lIPhlGuhlshlP.hlhhhhhss...hthlhslhhhhllp.l.spllpPhlhuct........hslpPlhlllullhushlhGhlGhllusPlhsllpshlpthh	..................................................................................................................hh...hhhh.h.h.hh...h.hh...h.h...hht...............sllhsh....lluhhl....sh.....l....h........p.........P...........l................h...............p............h...............l........p................c................h................t................h..............s.................R............s..............l............u...........s..............h.......l...h.........h......l..l.h...l....h.l....l...s.....h....h..l....h....h...l....h.......s.......l.....h...p...p...h.....s....p.........l....h.p..p..ls.............................................p.h..h....p....p.....h...p....p.....h....l....p....p.....l.....t..t.h..t.h...........................................tth..t..t..t..h.....s....p...h.....h...p.....p...h...t..s..p..h....................................hs.t.h....h....s....h....h...s....s....l.......s.......s......h...h....h.......t....h.......l...l...h...h.......l.h....s....h.......a......h....l....h...-....t....p....p....h..........h....p....h....h....h....p......h....h.....s....p....p.........p....t....p....h....t....p....l....h....p....p.h...spt.......lssaltu.ph....lhul...l.....hGl...h....s....h..l.....u......h......h......l........h........G..l.........sa...ul..l..l.ul..l..s..slhs..hlP.h...l...G......s..hl....u.h.l.P...s....s....l..h..s....h....h........h.............s...............s.......................h.t........h.l....h......l....l....l....h....h.h.ll...p..t.l.pu.s.l....l.pPhlhucs............lslpslh.lllu.l.lhu...u.t.......l...h....G........h...h......G.hllulPlhulhtslhp...h..................................................................	0	829	1727	2265
+4848	PF03715	Noc2	UPF0120; 	Noc2p family	Bateman A	anon	SWISS-PROT	Family	At least one member, Noc2p from yeast, is required for a late step in 60S subunit export from the nucleus [2]. It has also been shown to co-precipitate with Nug1p, a nuclear GTPase also required for  ribosome nucleus export [1]. This family was formerly known as UPF0120.	19.80	19.80	19.90	22.30	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.84	0.70	-5.56	38	404	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	292	0	273	396	6	277.60	32	42.37	CHANGED	psshl-slLKssYpual+ss+h.ssh+ohshINFh+NossELau.lD.shuYphuFtaIRQLAIHLRsulssps........c...............-ua+sVYNWQalauLchWucVLuth..........tspposLcsLlYPLVQlslGsh+L.lPospaFPLRhall+uLl+LS.psTusaIPlhPhLhElLsSs......phs+s.s........................+....pu.shcshDFphsl+sspuhLpo+sYp-ulh-plh-LlsEahshaupsIuFPELshPsllpL++ahKps.......+ss+as+plppLlcKlppsupaIpc+Rsp..lsFuPsspspVcsFhp-hc..hcpTPLspYhts.+	.............................................t..hhpslLKthY.shlps......s..+h...ss...spshs..hIsh.hppohsELau.l....D...shuYppuFhaIRQLAlHLRsuhstpp................K...........................................................-sapsVYNWQalpsLchWspVLut.............spps.LpsLlYPLsQ.....lhlGsh+L.lPo..s.paaPLRhphl+sLhpLu....p....so.ssaIPlhshll..E...lLpps.......php+t..s.......................................p..........ps.sh+slsFsshl+hsps..Lps+sap-.ulh-p...............lh-LlhEahsh..hup..sIuFPELshPsllp.......LKpalKps.....................+ssphs.......ptlppLlpKlppNupaIpp+R.pp..lsFuspctttVpta.pphp...ptTPLstaht........................................................	0	102	161	232
+4849	PF03661	UPF0121		Uncharacterised protein family (UPF0121)	Bateman A	anon	SWISS-PROT	Family	Uncharacterised integral membrane protein family.	20.60	20.60	20.70	21.80	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.58	0.70	-5.18	7	337	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	274	0	234	322	0	229.50	21	81.74	CHANGED	.ps..s..s.s....uuhhpalhsN+l-TAhWhuRlhTlahulhalLPhlssp.uhs....hYp+sLlAsAATSALRLHQRLP.pFp..hSRtFLtphhhEDSsHYLlaSllFl.shPlohsllPVhLFulLHusoaopKlLDshG............pNShhhsR....hlshlphppQNIL+hIACsEIhLMPhslhhhFSGpuullhPFlYY+FLshRYSSRRNPYsRshFsElRlslpslAhpspCPshlp+hlhsuIsFlSRLAPssh	.................................................................................................ht..........................................h.ah..phhslh.s.sh.h.ah.l..s..h.h....s.......p.....t..tt....hYphu......hl.uss.h.o......u....l...h...l...a..p.....p..h....thp.........h...s....t...t..h...l...t....p...h...l..t....-.-.sspY..L.....hh.uLh.a.l....h....s..h.....l.h..h......u.llPh.hlaSlhHsu.oas.....c.....p.hL.............sh..s.............................tp.s.t.h.tc......lhp...hVppttps....hht.h...s.AssEl........h.....l.h.h.h.h.l.h..h.lh..t......ptSh........l..h.l.Yhp.FL+hRY...pp....ssaspshatphphhl-t.hh.p...tsP.hhtp................h.................................................................................	0	77	126	188
+4850	PF04297	UPF0122		Putative helix-turn-helix protein, YlxM / p13 like	Kerrison ND, Finn RD	anon	COG2739	Family	Members of this family are predicted to contain a helix-turn-helix motif,  for example residues 37-55 in Mycoplasma mycoides p13 (Swiss:O05290). Genes encoding family members are often part of operons that encode  components of the SRP pathway, and this protein may regulate the expression of an operon related to the SRP pathway [1].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.21	0.72	-3.99	9	1476	2012-10-04 14:01:12	2003-04-07 12:59:11	9	2	1462	5	202	999	31	100.70	44	89.94	CHANGED	l-KTh+hshLF-hYtuLLTcKQtsYhpLYYh-DhSLuEIAEcaslSRQAVYDsIKRTpchLppYEpKLpLhpKaphRpclhpclp-ph.p.t...phhc.l	..........................EKs.RMN.hLF-FY.usL...L....T...c...KQ..ps..Yl.E.LYY.h-DaSLuEIAEpasVS....RQAVY....D....N....I.K..R..T.c.....c.l.L.E.-.YEpKLc....lhp....c....a......t.R....p....p....lh...c...pl....t...phhsp..p.........h................................................	0	92	147	176
+4851	PF03660	PHF5	UPF0123; 	PHF5-like protein	Bateman A, Wood V	anon	SWISS-PROT	Family	This family of proteins the superfamily of PHD-finger proteins. At least one example, from mouse,  may act as a chromatin-associated protein[1]. The S. pombe ini1 gene is essential, required for splicing [2]. It is localised in the nucleus, but not detected in the nucleolus and can be complemented by human ini1 [2].	26.70	26.70	27.30	30.50	23.80	26.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.82	0.72	-3.98	19	319	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	281	1	224	212	4	103.40	71	89.84	CHANGED	MSRHp.DLlhChKQPGtslGhLC-pCDGKCPlCD...SaV+P..pohVRICD-CSaG.......phss+CIlCG.......s.Gl.....s-AYYChECs+LEKDRDGCPRIlNlGSs+sDh...aap+K+ts	..............Mu+HHP.DLIhCRKQPGlAIGRLCEK.....CDGKCsICD....SYVRP.....sTLVRICDECNaG.......oYQGRCVICG.......GsGl.....SDAYYCpECTh.EKDRD..GCPKIlNLGSo+TDL...FYERKK.hu.........................	0	78	126	188
+4852	PF03658	Ub-RnfH	UPF0125;	RnfH family Ubiquitin	Bateman A, Burroughs AM, Iyer LM, Aravind L	anon	SWISS-PROT	Family	A member of the RnfH family of the ubiquitin superfamily. Members of this family strongly co-occur in two distinct gene neighborhood  contexts. In one it is associated with a START domain protein, a  membrane protein SmpA and the transfer mRNA binding protein SmpB.  This association suggests a possible role in the SmpB-tmRNA-based  tagging and degadation system of bacteria, which is interesting given that other members of the ubiquitin system are analogously involved  in protein-tagging and degradation across eukaryotes and various  prokaryotes. The second context in which the RnfH genes are present  is in a  membrane associated complex involved in transporting  electrons for various reductive reactions such as nitrogen  fixation [1].	22.40	22.40	22.70	23.30	22.20	19.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.55	0.72	-4.11	10	1334	2012-10-03 10:59:06	2003-04-07 12:59:11	9	1	1297	2	253	739	157	83.20	51	83.26	CHANGED	IcVEVVYAhPc+QhLpclsVs-GsTVc-AIppSGlLphaP-IDLppsKlGIFu+slK..L-ssLKDGDRIEIYRPLlsDPKElRRc	......................................ltVEVsY.A.L.P.-..+Qh.L.hp.lsl.......p-GuTVc-AIcsSGl.L.p.h.......hs-........I........D...L.............s....p...s...K.V.G..IaSRssK.......Lsssl+DGDRVEIYRPLlADPKElRRp...........	0	53	131	196
+4853	PF03458	UPF0126		UPF0126 domain	Yeats C	anon	Yeats C	Domain	Domain always found as pair in bacterial membrane proteins of unknown function. This domain contains three transmembrane helices. The conserved glycines are suggestive of  an ion channel (C. Yeats unpublished obs.).	23.40	23.40	23.80	23.90	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.85	0.72	-4.36	177	6692	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	2470	0	1367	3826	471	80.50	31	75.05	CHANGED	lhhhDhlGlssFulsGshhAhp..th......s..h.hssllluhlTulGGGhlRD.lLhsp.h..Phhhh..p.phYs....hsulhuuhl.hhhhhthhh	.................hlLDhlGlssFulsGshhAh....ch...ph.........s.....h..hssllhuslTulG.GGhlRD.lL.hsc.h...Plhhh.........c...thYs.............s.s.s.hh.uull.hhhhh...hh..........................	0	358	812	1115
+4854	PF03673	UPF0128		Uncharacterised protein family (UPF0128)	Bateman A	anon	SWISS-PROT	Family	The members of this family are about 240 amino acids in length.  The proteins are as yet uncharacterised.	20.40	20.40	20.80	20.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.36	0.70	-5.07	5	20	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	20	0	16	22	0	215.40	49	96.05	CHANGED	MLlNTLVFETLGsPEKEREFKlKDLK+WGFDLlLGKlDGc-AYFsSchusREsGDKaocsGKEYEIcElLcELPKNs+LaA+IEhEcGpAYLhsaLREED.pNhPlL+pPAsplLhAFaKK+KLspLlKsl+uVGloT-FaKc+.GlcSlPLPYEELPPVARRFLR-ARKVEK-.sGFGRluFAYFGEs+-K-sRYRLpWLLPTIALFDl-IScKlDKsLuhLK	..l.shhlhEshGss.pERcFKhKsLKtWGaDLhhGpI-GccsYFsuchsc+ctG-p....YspcG+EYclpEsh.cElPKNs+LhA+I.hEcGpsYL..hhaLc-ED.psh.lh+.ssthlLhtFacKcKLspLlKtl+sVGloo-hhKcs.hhcuhPLPYEEhPPhsRRhLR-sRcVc+-.TGFGRhsFtYaGE.cDtptpYRlpWhLPTItLFDl-IApclDKsLuhLc....	0	6	6	9
+4857	PF03647	Tmemb_14	UPF0136; TMEM14; 	Transmembrane proteins 14C	Bateman A	anon	Pfam-B_2984 (release 7.0)	Family	This family of short membrane proteins are as yet uncharacterised.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.05	0.72	-3.59	61	574	2009-01-15 18:05:59	2003-04-07 12:59:11	8	12	290	3	347	543	6	92.90	30	64.14	CHANGED	phhuhshuuLlssGGlhGYs+sGShsSLhAGlshGslhuhu......uahlp.......spshuhtlul.ssSs.............sLssshshR....hhpop.KhhPsslhhslusshsshhhh	.................hhuhsausLlssGGlhGYh+sGShsSLhA.GlhhGslhhhu.............uahhp..........ppshshhl....uL.hsos................................sLssshuhR...........hhp.ot.K.hhPsGlhsshohhhhshh..h......................................	0	95	186	274
+4858	PF03677	UPF0137		Uncharacterised protein family (UPF0137)	Bateman A	anon	SWISS-PROT	Family	This family includes GP6-D a virulence plasmid encoded protein.	34.00	34.00	34.50	34.20	32.00	31.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.76	0.70	-4.84	6	77	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	47	0	11	42	3	230.60	45	92.16	CHANGED	MupLKp.h-shFKKNppsphEshpKKchpt-.......lhssoLSspEcp+lcpLl..p+YsFcDE.hpccDltulppLouQIKpIp+QpVLLhGE+IhKVR-LL+o..apEssFSuWl.Lsaus+posYNhLsYYELFhsLP-.sLKlEhpplPhpAsYhLASRcGo.E+K.clI+phpG.opophl-Ilc+.hP.l...........ss-p+pppLScphlplL....+llspsscLSp.spslLcpLhcKlp.......spsp	................................MuplKp.h-shFKKs.p...sphpshtK+phphE.......hhssp.LSSpEctphcpLl..EcYsaucE.h.ppDltp....lphLouQlKpIp+QtVLLhGE+IhKVR-lL+s..ap-ssFSuWl.Lsaus+posYNhLsYYELF.sLPc.oL+hEhpplPhpAsYhLASRcGs.ccK.-lIcphpG.opuEllcllc+.hP.h...........ss-c+ppsLupphhphh.....+llpps.s.clSppp...LcpLhcKhp...Ksp.............................	0	5	7	10
+4859	PF03669	UPF0139		Uncharacterised protein family (UPF0139)	Bateman A	anon	SWISS-PROT	Family	\N	20.90	20.90	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.48	0.72	-4.51	9	201	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	167	0	134	179	1	98.30	39	82.70	CHANGED	hssssDPRRss+hpRYKPs..oss......-DhhsDYMNlLGMlFSMCGLMh+hKWCuWlAlhCSsISFANsRs.S-DsKQlhSSFMLSlSAVVMSYLQNPpPhoss	........................h..thsDPR.RssplhpYpsPssps..............-D.ssDYhslLuhlFuMsGlMh..+.hKaCuWhAlhhShhS.aANs...+s....opDs.KQ.h.....h.....SS.F..M.......hSl.AlVhoYLtsstsh.........................................	0	46	71	107
+4860	PF03686	UPF0146		Uncharacterised protein family (UPF0146)	Bateman A	anon	SWISS-PROT	Domain	The function of this family of proteins is unknown.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.51	0.71	-4.31	6	77	2012-10-10 17:06:42	2003-04-07 12:59:11	8	1	77	1	56	119	15	127.40	30	93.74	CHANGED	Ml-lAchIAcEst+G.KVVEVGIGhahcVActLpcpG.hDllAsDIscc...pA..pGlphhhDDlhsPslulYcuAchIYSIRPPPElhssll-lu+tVsAshhIpPLsG-.s...pphKLlNY+Gt.FYth-s	......................h....t.pts..+lVElGlGt.p.hcVAttLp.ct.G..h-.VhssDlptp.............ts....tGlp.....hhhDDlh......s....Ps...h.....plYc..sAclIYS..lRPPsELp.sllcl..A+clsuslllpsLus-t........t.h+lhsapt..hYh...............................................................................	0	10	32	47
+4861	PF03685	UPF0147		Uncharacterised protein family (UPF0147)	Bateman A	anon	SWISS-PROT	Family	This family of small proteins have no known function.	21.10	21.10	21.20	27.30	21.00	19.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.87	0.72	-4.11	23	121	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	118	5	81	116	72	84.00	45	95.16	CHANGED	shtss-cpl+pshthL.pcIlsDsoVPRNIRRAAs-uhctLpscppssuVRAAsAISlLD-ISpDPNMPhHsRThIWsllSpLEol+	......h..pscpplcpslthL.ppIlpDooVPRNIRRAAs-uhctLpspsps.uVRAAsAIulL--ISpDPNMPhHsRThIWpllStLEol+.	0	23	47	65
+4863	PF03695	UPF0149		Uncharacterised protein family (UPF0149)	Bateman A	anon	SWISS-PROT	Domain	The protein in this family are about 190 amino acids long.  The function of these proteins is unknown.	25.00	25.00	27.50	27.40	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.49	0.71	-4.39	169	2253	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1277	1	349	1168	204	173.10	26	84.88	CHANGED	hppLpph..Lp.......ttt.h......shsplcGhLsullsu.....stt..lss.ppWl...shlhs.......................pstt.s..pphhphlh...............phhpphtppL......tp.ts.th...................p.hhspp..ps.......tpspslppWspGFltGh...sl.tppp...................pphssp.......hpthlps...lttlupht......ptt.................spcp..tppthtplhE.hh..sshhl......ap.htttt	...............................................p.lsph..Ls.........ppu.hlssAEhcGllouhlsu......spt...h.s...ppWL...shlas......................p.pu.t.h..pchhphlh...............phhsssuppL.....p-.ts..F......................p.h...hspp..-s..........pcsssltpWspGFhtGlul.htsc......................hspl..ss-................htpulcs.....lt.lup.t.......spcp..................spcp....htpuh-cll-hl+hAsLhlashah..............................................................................................	0	58	143	260
+4864	PF03681	UPF0150		Uncharacterised protein family (UPF0150)	Bateman A	anon	SWISS-PROT	Domain	This family of small proteins is uncharacterised. In Swiss:Q9A3L8 this domain is found next to a DNA binding helix-turn-helix domain Pfam:PF01402, which suggests that this is some kind of ligand binding domain. The structure of this domain suggests that these domains oligomerise and due to structural similarities may bind to RNA. The monomer adopts an alpha-beta-beta-beta-alpha fold and forms a homotetramer. Based on the properties and functions of structural homologues of the HB8 monomer, the protein is speculated to be involved in RNA metabolism, including RNA binding and cleavage [1].	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.29	0.72	-4.33	144	2769	2012-10-02 16:06:15	2003-04-07 12:59:11	10	19	1473	7	747	2274	167	47.90	27	43.64	CHANGED	pYssllct...p-css....ahsphP-ls....ush....opG-Th-EAhpphp-Alphhlps	.................Ysshlp.....tccsu....ahsp..hPDl.s........ush....opG-.Th-EAhppsp-Althhlt...............	0	231	511	642
+4865	PF03692	CxxCxxCC	UPF0153; FliB;	Putative zinc- or iron-chelating domain	Bateman A	anon	SWISS-PROT	Family	This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex.  However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that chelates iron or zinc ions.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.35	0.72	-11.12	0.72	-3.51	35	4094	2009-01-15 18:05:59	2003-04-07 12:59:11	10	5	2313	0	1272	3041	657	89.40	24	56.80	CHANGED	hCps....C.GtCCh................htlptpDhtcl.thsth......................................tChhLc.tcst...pCpl.....Yp..pR....PpsC+hhPh....................tththhs.sCs	.....................................Cps....C....Gt.CCh..........................................hp..l....t.p..-...ht.c.l....th..t...t...h..............................................................................................sC......hhL.s.....tcst...........pCpl.....Yp.....pR......PpsC+hh.h............................................................................................................	0	397	784	1044
+4866	PF03672	UPF0154		Uncharacterised protein family (UPF0154)	Bateman A	anon	SWISS-PROT	Family	This family contains a set of short bacterial proteins of unknown function.	20.90	20.90	20.90	21.50	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.03	0.72	-4.35	5	1101	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1097	0	123	358	3	64.60	49	82.30	CHANGED	LsIVLuLLlGlhLGaFISpKhMK+hLKKNPPINEstlRhMhtQMGRKPSEsQINQlM+uhpsQp	...................lllVlAL.l...sGh....lG...GFal.ARKhhpcal..pc..NPPlNE-MlRhMMhQMGQKPSp+KlpQhMptMp+Q.t....	0	36	71	96
+4867	PF03693	RHH_2		Uncharacterised protein family (UPF0156)	Bateman A	anon	SWISS-PROT	Family	This family of proteins are about 80 amino acids in length and their function is unknown. The proteins contain a conserved GRY motif. This family appears to be related to ribbon-helix-helix DNA-binding proteins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.58	0.72	-3.81	5	1166	2012-10-02 18:44:02	2003-04-07 12:59:11	9	7	788	2	292	822	140	77.80	31	88.88	CHANGED	MuKNTSVsLGEHFsuFIDuQVQuGRYGSASEVIRSALRLLE-pETKLcALRsALIEGEcSG-ucsFDhDuFlsE+cpcssp	.......................h.olsL.s-chcpFIcshlp..SGcYsotSEVlR-u...L....R......L.L....c....c....+....E....s.....c....l....p....u....L...R.p....h.l..t...pG....h...p....S...G.......s....p...h....p..p.h.........pth..........................................	0	68	163	215
+4868	PF04229	GrpB	UPF0157;	GrpB protein	Kerrison ND, Finn RD, Eberhardt R	anon	COG2320	Domain	This family has been suggested to belong to the nucleotidyltransferase superfamily [1].  It occurs at the C-terminus of dephospho-CoA kinase (CoaE) in a number of cases, where it plays a role in the proper folding of the enzyme [2].	20.10	20.10	20.40	24.40	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.88	0.71	-4.53	107	1502	2012-10-02 22:47:23	2003-04-07 12:59:11	9	16	1107	1	300	1132	38	162.00	27	79.16	CHANGED	tttlplss.ass.pWsppapptppplpshl....usphl.......plcHIGSTuV......PGLsAKPlIDlhlsVpshpshc..ph.spsLpshGY.h.ht.c.sh.t..............+chFh+......................sp..+stplHlhtt..uss.phpcpLhFRDaLR..scspttppYtplKppLu...tphsp...shptYssuKs..salpclh..pcA	.............................t...l.lhsass.pWtppapc.pptltshl....spthl.......................plcHIGSTul......sslsAKP.IIDIhlt..Vp.shp..p.h.s..ph..tctLpt..l.G....Yhh..t...c...shsp..................+h.h.ht+.........................ttttcsh+lHlhth..sst..phpppLhFRDaLp..spsphsppYsplKppLs......tphst.......shppYspsKssalpplhpc.....................	1	98	188	247
+4869	PF03682	UPF0158		Uncharacterised protein family (UPF0158)	Bateman A	anon	SWISS-PROT	Family	\N	20.40	20.40	20.60	21.10	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.96	0.71	-4.62	3	182	2009-09-11 06:49:59	2003-04-07 12:59:11	8	7	173	0	63	158	12	143.10	24	66.17	CHANGED	QNPLlLRlcRLM-AFAKSDDERDFYLDRlEGFllYIDLDKPQsELDAL.pELEENuDRYCLIPKLSFYEoKKIMEsFVNEKVYDIDTKEKLL-IlQSKcAREsFLEFLYDHcoEQEKWQQFYsERSRIRIIEWLRsNcFQFVFEEDLDhP+pLLEpLK+sLFs	.............................................................................l.h.pl....A..ht.s...s...th.p..haLDh.pG..lh.hl....s....-......................s.....t..-h.....-....th..............p..-.........l.....-...p.............s......s...-.R.Yh.hlP.phs.......h..p.t.hplMcsFlpp.l..t.-.ch+ppL..hpsl.p.u.+s.u.acpF+chlh.-.a.p..hccWhpapscph+thhh-.WLcpptht......................................................................	1	29	50	57
+4870	PF03690	UPF0160		Uncharacterised protein family (UPF0160)	Bateman A	anon	SWISS-PROT	Family	This family of proteins contains a large number of metal binding residues. The patterns are suggestive of a phosphoesterase function.  The  conserved DHH motif may mean this family is related to Pfam:PF01368.	20.70	20.70	22.10	23.00	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.07	0.70	-5.01	69	570	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	459	0	317	545	50	288.60	36	89.24	CHANGED	hpIuTHsGsFHsDEsLAshhL+h.hstat.............sAcllRoRDsphl.spsD..lVlDVGGhYDs...................pppRaDHHQ+sFsthh........p.thsp........+LSSAGLlapHFG+cllpphht.........................hscpp...lphlapplYpsFlcslDAlDNG..lsph...................t...ta..sshoLuuhluphN..PsWs-.t.......t.tsp-ptFtpAhphsup.hhptlcthstshlsA+slVtpAhpptht...sGcIlhL.sp.hsPW+caLaplEp-tth.................h..aVlascs....spWRlpsVsh.pssoFcsRtsLPcsW+GL+D.c-Lsph..........oGIs.GslFsHsuGFIGGscohEusLpMAch.uLp	................................hluTH.sGsFH............sDEsLAshhL+h..ls..tap..............sucl.lRT.RD..s...phl..sps-................lVlDVGG.YDs...................tppRaDHHQ+sFstsh..........tthts.......+LSSAGLlap.HaGcplltphht............................sptp..l..phlapplYp.sFlcslDAhDN.G.ls.h...................t....tat.hshsLushluphN.........PtWsp.t...........................tsp-ptFtpAhphstp.FhptlphhstsalsA+slVt.......pAh.p.p.phph.......p...sGcIlhL...sp..hsPWKc+LaplE..p-..ht...........................hhaVlascp....tspWRlpsVsh.p.so.Fp.sRhsL.Pc.sWRGL+D.cpLsph............oG..Is.GslFsHsuGF..IG.G...scohEuAlphAphuL......................................	0	126	196	269
+4871	PF03687	UPF0164		Uncharacterised protein family (UPF0164)	Bateman A	anon	SWISS-PROT	Family	This family of uncharacterised proteins are only found in Treponema pallidum. They contain a putative signal peptide so may be secreted proteins.	25.90	25.90	26.30	26.20	24.40	25.80	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.91	0.70	-5.90	6	67	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	30	0	13	55	29	294.80	33	72.18	CHANGED	sl....thhshat+suthssuhuhssslushAuusu.h.otpc.Kthu+.....Rsl.lPoGGRapsLssuFTALAsDASFFEANPAGSAshs+sELuhFHsstlssSHsETLSaVtpsGphGYGsShRsFaP-.shp..hu.p............KspGhlu....IhNhu+tF.utYRFKGlSlGuNlKsGaR......................supp.pHlsVsuDlGLphshsVAKsFuScEPNhalGLuh+NlGhoVKs........................................ssssssts.ssstssHsTsohltlGFAYRPlpaFLFulGlphthNVpslpsss..hhuhuFhh..hp.hsh.sshhhpG...tt.thouGuEhp.ssh+ls	................................h......hh.h..hhhshhsh...ssthsu........stt..p.pt.sc.....t.l.lsoGG..RhphLssuFTALAsDASFFEANPAGSAshscsElu.hFHsstlssSHh-Tluastptsph.G.YGsS...h+hFas..sh....h........................pthGhlu....IhNhu+th.ttaRFtGlSlGsNlKhGaR..................................pupt.pHlslsuDlGLphshsVuKsFuSpEPNhalGlshpNlGholps....................................................sstpsc.shsohlhhuhAYpPlphFLFuhGlph.hNlpsl.tt.......t.....p......p....hhuhuhhh.shphlsh.uuhhhpu....tphRhusGuEhphsphpl...........................................................................................................................................	0	8	12	12
+4872	PF03691	UPF0167		Uncharacterised protein family (UPF0167)	Bateman A	anon	SWISS-PROT	Family	The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.	25.00	25.00	28.60	28.30	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.50	0.71	-4.86	11	334	2009-09-11 05:14:47	2003-04-07 12:59:11	9	1	317	0	27	155	5	175.40	52	89.45	CHANGED	hp....LPpF+YHPc..PlsoGuhcps..sssCsCCspspshhYoGshYsh--lp..slCPWCIADGoAAc+a-GsFpDDhslpss................sspphlcElhcRTPGYsuWQQEhWLuHCsDhCAFlGhVGhsEltsL..psl-slhs-ht....sutchpcLhptLs+sGp.hsuYLFpClaCGpahhahDhu	.............sh..psLPpF+YHPc..PLpTG.uF-pD..sVpCsCCcQps..slhYoGPhYsh.....-E.l-...aLCPWCIADGSAAcKFsGoFpDDssl-..ss-.......................hP-EhlcELlcRTPGYpGWQ.Q.EaWLuHCGDaCAFlGaV.G.hs-lcDh...Dt.....hssLccDhc......huh+.p.-ltcsLp+sGc...spGYLFRCLHCGKh+LauDFp........................................................................	0	10	17	22
+4874	PF03666	NPR3	UPF0171;	Nitrogen Permease regulator of amino acid transport activity 3	Marshall M	anon	SWISS-PROT	Family	This family, also known in yeasts as Rmd11, complexes with NPR2, Pfam:PF06218. This complex heterodimer is responsible for inactivating TORC1. an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation.	27.50	27.50	27.60	28.20	27.40	27.20	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.54	0.70	-5.95	19	428	2012-10-01 20:21:22	2003-04-07 12:59:11	8	4	229	0	267	413	2	250.80	23	57.72	CHANGED	GFsschLsplLsPt+phCNp+FElslDslhFlGhPlahtcsGpW+ppcppp...t.ttp.......................................ts..ppttpstp......................t.csshsMFplVFlhN.P.......hhEhs.+lccMacallp+lulsL+apQs+psYVt+EsctILpl+-...th.cpptthps..........hhppllppSSLA+slp-sacuIspscIAsLplss....hhhShQIPhpsch.pLPp.pl.Phh.uoaLoo...................................ts..p.p-th.p...............pthl..aauLLLLcDspsllp-lts.ssss.....hls...................chl+hhpP....shSlhplup..............................ssslsh.splcphAhHLlYWR+ARlI.PLss+ssYlVSP.Aslp..............................pL.pstptFpppFPshPoLPpFLshLS...tpP+sauslIP...S+-H+slYhphLuWLlRaGaVTQLpTFlalhlspcIKhc	.....................................................................................................................................................................................................................................................................................h...h..l..phshhh...p.p.tal.pp.t.h....tp...................................................................................................................h...h......................................................................................................................................................................................h....shhhh..t.............h.................h..............................................hhp..ps.......sh..ht....................................h......h..hs.ahh.htpAhhl..lp...p...hahhss...................................................at..F..s...................L..hlt.hs.................s.......ht..hh.............................................h.hl..hhht.thh......................................	0	88	131	210
+4875	PF03665	UPF0172		Uncharacterised protein family (UPF0172)	Howe K	anon	SWISS-PROT	Family	In Chlamydomonas reinhardtii the protein TLA1 (truncated light-harvesting chlorophyll antenna size) apparently regulates genes that define the chlorophyll-a antenna size in the photosynthetic apparatus [1]. This family was formerly known as UPF0172.	24.40	24.40	24.60	25.70	22.60	24.00	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.95	0.71	-4.82	22	258	2012-10-10 14:49:21	2003-04-07 12:59:11	8	3	170	0	158	241	5	183.70	34	92.45	CHANGED	hsplplospAYsKhhLHuhKYPpsuVNGlLluc..........................sspssp............lhloDslPLFH..tplsLsPhLElALspl-sasppps.hsIlGYYpANpph.sDss.ssl.At+lu-+luc....phssAsllhlcNpcls.sscsssht..................lap...ppts+Wspsc.t..hhtptppspchlpph...lpsttapplsDFDsHL-chppDWhNppLsp	.........................................phclospAYsKhhLHuuKYP.p.sAVNGlLlup.......................................................pp..p..ss..p............lhl.sDslPLFH..tpLsLsPMLEl.ALs.......l-s.a.......s.p....p.......p.......u......hsIsGYYpAN...pph..pD..ss....s..s.l..AtKlAs+Is-..........tas.sA.sllh.lDNp+hs..p.ts..sshh..................lhp......ppss+Wpt..pc........t.....h......hp.p..tps....pp..hsuph...lcsps..appLlDFDsHLDDlppDWhN.tl..............................	0	63	85	119
+4876	PF02476	US2		US2 family	Mian N, Bateman A	anon	Pfam-B_2256 (release 5.4)	Family	This is a family of unique short (US) region proteins from the  herpesvirus strain. The US2 family have no known function. 	25.00	25.00	30.80	29.80	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.97	0.71	-3.65	15	202	2009-01-15 18:05:59	2003-04-07 12:59:11	10	2	32	0	0	136	0	150.10	66	66.65	CHANGED	hLsSshsss.psaHLWVlGAADLCtPsl-plsss+...RLlssclsssWs.GtsW.lPs.......phtshhTss.........Ws.........Ph.sssps...ltss.sshchhYullss...................s.h.Psssspssspsssps.....spssCsss	....HLNSSLIIN.QPYHLWVLGAADLCKPVFDLIPGPK...RMVYAEIADEF..HKSW.QPPFVCGKLFETIPWTTVE..................HNHPLKLRAAGGEDTVVGECGFSKHSSNS..LV+PPTVKRVIYAVVDPARL.......REIPAPGRPLPRh......R.....PSEGGMRAPRRRSRA..PAPARSTAs..AAs..........................................................................	0	0	0	0
+4878	PF03683	UPF0175		Uncharacterised protein family (UPF0175)	Bateman A	anon	SWISS-PROT	Family	This family contains small proteins of unknown function.	26.40	26.40	26.50	26.50	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.23	0.72	-4.51	47	419	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	182	0	161	473	43	71.90	24	80.33	CHANGED	plPctlh.shp.s.pth.pEl+htlAlpLYppstlShG+AAclAGl.o+hcFhchLuc+sls.hp..hs.c-LpcDlpss	.....................................th...ht...t.t...pch+hthAlpLY...ppsclShupAAclAGh.sch-Fh.phLtccsls.hp...h.s..--lpp-lp..h..................	0	47	129	154
+4879	PF03698	UPF0180		Uncharacterised protein family (UPF0180)	Bateman A	anon	SWISS-PROT	Family	The members of this family are small uncharacterised proteins.	22.30	22.30	22.60	27.90	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.42	0.72	-4.14	18	218	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	204	0	53	136	0	78.90	47	96.57	CHANGED	hp+.IuVEpuLoslp-tL+p+GY-Vlplc....spp......chpssDssVVTGhDsNhhGIpDssTpu.sVIcAsGhTA-ElsppVEp+lp	......t+IGVEsoLo.cVppALpppGaEVVsLp.....scp.......DspuCDssV...VT...G.......pD........o.N...h..hGI...sD.ssh.cu.sVIsApGhTs-EIsppVEsR..t....................................	0	25	42	46
+4880	PF03701	UPF0181		Uncharacterised protein family (UPF0181)	Bateman A	anon	SWISS-PROT	Family	This family contains small proteins of about 50 amino acids of unknown function.\	      The family includes YoaH Swiss:P76260.	22.20	22.20	22.70	22.20	21.10	22.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.51	0.72	-4.66	18	721	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	718	0	66	197	1	51.70	70	86.32	CHANGED	Mh.sshPuLoHEpQQpAVE+IQcLMucGhSSGEAItlVApElR.Ep+ppcppst	....MF.AGLPSLTHEQQQKAVERIQELMAQGMSSGpAIAlVApELR.AsHoGE+I.VA......	0	4	20	46
+4881	PF03670	UPF0184		Uncharacterised protein family (UPF0184)	Bateman A	anon	SWISS-PROT	Family	\N	20.90	20.90	20.90	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.81	0.72	-3.81	3	137	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	118	0	63	90	1	73.80	36	65.06	CHANGED	MSGPNGDsshSVEDGups--D-FGppEYEAINSMLDQINSsLDcLEERNDcLpu+L+ELLESNRQsRLEFppQLu.cAPp-uSs	..........................................................................................p...p..hAtlNSpLDQLNSsLD+LE-+...sDHLcupL+pLhp........................pt.........................	0	17	22	38
+4882	PF04050	Upf2		Up-frameshift suppressor 2 	Wood V, Finn RD	anon	Pfam-B_14721 (release 7.3);	Family	Transcripts harbouring premature signals for translation termination  are recognised and rapidly degraded by eukaryotic cells through a  pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3)  are required for nonsense-mediated mRNA decay [1].	25.00	25.00	25.00	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.20	0.71	-4.49	16	283	2012-10-11 20:00:59	2003-04-07 12:59:11	9	11	232	2	203	287	0	170.80	27	16.56	CHANGED	cussSss--Gh.....---shs-t-c-p-....So-Ec-sstsssppst.....co-uE-EplhVoRpp--hDPEsE..AEFDREF-KMMu..................ESh-SRKaE..++ssFDlPLPM+htscsss.......ssspsssE......tssssssTMsFoLhTK.KGNKQQTRsl-lPSDSohAhuM+sQQpA-pEEQQRIKpLVLN	................................................................................ttts.......ps........-ppt.......p.t...-...p-cp...........ppc.-p.p...p.pt..p....-..ttppp.......................psp.p-.cpp.hh......l...pt...t.t.......p..hs...s.p...t-....t-F.ppth.pKMht....................................E.u..h......p...p.RphE....+h..tt.....h..Dl....s.l.......Ph..phpsptpp...........................................ts..t-..................spstsssshsFslLo+...+GNK.QQ.........h..+plplPssSphAhshhpp.ppA...-p-E+p+lKpLsLp..................................	0	60	102	165
+4883	PF01255	Prenyltransf	UPF0015;UPP_synthetase; 	Putative undecaprenyl diphosphate synthase	Finn RD, Bateman A	anon	Prosite	Family	Previously known as uncharacterized protein family UPF0015, a single member of this family Swiss:O82827 has been identified as an undecaprenyl diphosphate synthase [1].	20.60	20.60	20.90	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.40	0.70	-5.22	94	5931	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	4761	48	1691	4210	2997	213.10	40	85.11	CHANGED	I.MDGNtRWA+p+....shs.pttGHptGspslccllchshch..GlchlTlYAFSsENa.pRspp.EVshLhpLhpphl.pc.hpphp...p...psl+l+hlGch.stL.sppltptlpcspptT.p....sss.shpLslAlsYGGRpEIh..........cAs+plh...............................................pth.tspls.pp...................................................lsc..ph....l...pptLhs..ssh.P............s...DLlIRTSGEpRLSNFLLWQsuYuE..laFscshWPDFsttchhpAlppYptR...........pR+FGt	.............................................................................................IMDGNGRWA+p+....s.h.s....Rs....h....GH...........+tG...hc.sl.cchlphst.ch....GlchLTlYAFSo...ENW.pRP.pp.EVshLMpLhhphl.cp..l.tph.......p....c.....psl+lch.l.G.ch...s..p..L..sppltctlppu.....p...p..h.T...t......................s.Ns....u.......lpLsl.AhN....Y....GG.RtEIs..........pAs.+pls......................................................................................................pp..s...t..p...u.p....l.p....s...p..c..............................................................................................IsE....ch....l.spaLhs....ssh..P...........cs.DLlIRTSGE...p.Rl..SN.FLLWQhAY...uE...h.............aFo.-..sLW......PDFscpc.hhpA.....ltpapp.R.cRRFG.s..............................................................................	1	575	1096	1447
+4884	PF00449	Urease_alpha	urease; 	Urease alpha-subunit, N-terminal domain	Finn RD, Griffiths-Jones SR	anon	Prosite	Domain	The N-terminal domain is a composite domain and plays a major  trimer stabilising role by contacting the catalytic domain of the symmetry related alpha-subunit.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.56	0.71	-3.97	117	1905	2012-10-03 00:45:34	2003-04-07 12:59:11	15	17	1537	48	464	1638	555	117.10	58	20.98	CHANGED	hclsRptYAshaGPT....sGD+lRLuDT-LhlEVE+DaT......sY............G-EspFGGGKVIRDGMGQuptsssst......sl..DhVITNAlIlDa.hGIlKADIGIK-G+IsuIGKAGNPDh.sGVs................lllGsuTElI	.........................h.ploRptYAshaGPT....sGD+lRLuDTsLhlElE+Dho.............sY.................G-Esp.FGGGKsIRDGMGQuptsst-t.........shDhVITNAlIlDa..h.........G..I..lKADIGIKcG+IsuIGK.AG.NPDl...sGVs................lllGsuTElI..................	0	139	288	388
+4885	PF00699	Urease_beta		Urease beta subunit	Bateman A, Griffiths-Jones SR	anon	Pfam-B_405 (release 2.1)	Domain	This subunit is known as alpha in Heliobacter.	25.00	25.00	36.20	30.30	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.02	0.72	-4.16	165	1820	2009-01-15 18:05:59	2003-04-07 12:59:11	15	16	1525	48	471	1322	409	99.30	54	51.53	CHANGED	IPGElh.s...ssGc...IpLNsGR.p..slslpVsNoGDRPlQVGSHYHFhEsNsA.LpF.........DRptAhGhRLsIsAGTAVRFEP.Gpp+pVpLVshuGpRplaGFsuhltGtL	..................lPGElh....h...ts..s.-......IplNsG....+...t..shslpVtNoGDRPlQVGSHaHFaEsNsA.LpF.............DR....ptA.....hGhRLDIsAGTAVRFEP.Gp..p+pVpLVshuGpRplaGFpuhlsG..........................	0	134	289	393
+4886	PF00547	Urease_gamma	urease_gamma; 	Urease, gamma subunit	Bateman A	anon	SCOP	Domain	Urease is a nickel-binding  enzyme that  catalyses the hydrolysis of  urea  to  carbon  dioxide and ammonia.	23.90	23.90	24.10	24.70	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.08	0.72	-3.97	85	1774	2009-01-15 18:05:59	2003-04-07 12:59:11	13	11	1506	51	477	1161	409	96.50	60	54.59	CHANGED	McLoP+Ep-KL.llasAupLAc+R+sRGLKLNaPEAlAlIostlhEG.ARDG.+..........oVA-LMshGpplLsc--VM-GVs-Mlp-lQVEATFPDGTKLVTVHsPI	..................McLTPREpDKL.hlhhAA.lAcRRpuRGLKLNaPEAlAlIostllE..........G.....ARDG.+................oVAELMphG..pplLs.................+-DVM-GVs-MIs-lQVEATFPDGTKLVTVHpPI..............	0	139	295	399
+4887	PF01774	UreD		UreD urease accessory protein	Bashton M, Bateman A	anon	Pfam-B_1109 (release 4.2)	Family	UreD is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid [2]. UreD is involved in  activation of the urease enzyme via the UreD-UreF-UreG-urease complex [1] and is required for urease nickel metallocenter assembly [3].  See also UreF Pfam:PF01730, UreG Pfam:PF01495. 	20.40	20.40	22.20	22.00	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.25	0.70	-4.85	163	1645	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	1448	2	449	1350	498	205.80	23	73.12	CHANGED	pshllpsu..GGlluG.Dplslslplsssu+shlTT.tuAsKlY+..........................u.sut...............................up.QphplplsssAtL-aLPp-sIhFssuphppphplcL...........sssAphlhhEhls...hGRs..u.tG..................................Epa........shsph.csphclhp.....ss..........c..l.hh.-phtL.psst.........tthss.ssh.........suhsshuollhhu...................ts.......p.th.hptl+..thh.......................t.th.hGs.ohh........sshlllRhLusssps...l+phh	..............................hhllssuGGlluG.Dchplslpl.pss..upshlTo.puAoKlY+.............................s..sst.................................................up.QphplplsssuhL-alPpssIsap.sAchtppsplpL......................pssupllhh-hlshGRs..s.pG..................................Eta........phsthpsphclhh.......cs....................ch...l....hh..-phhL.sssp.............t.hst...shh.................................................tshshhuolhhls.................................................................p.thhptlp....thh.........................t.sh..th.uh.otl............sshlhlRhhu.pst.lpth.h...................................................................................................	0	123	268	370
+4888	PF05194	UreE_C		UreE urease accessory protein, C-terminal domain	Finn RD	anon	Pfam-B_6279 (release 6.1)	Domain	UreE is a urease accessory protein. Urease Pfam:PF00449 hydrolyses  urea into ammonia and carbamic acid. The C-terminal region of members of this family contains a His rich Nickel binding site.	21.90	21.90	21.90	21.90	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.28	0.72	-3.88	99	1267	2009-09-11 21:12:50	2003-04-07 12:59:11	7	3	1165	35	255	871	383	91.80	29	53.94	CHANGED	sEslhplpu....ss.hpLs.........+hAaHLGNRHlPh......pltss.....tlhlt...tD+VlccMLct...........L.G.....hplpphptPFpPEsGAY..................tt...ctHs..........................HsHs	........................Ecllhlps.....p.sh.hphu.........clAacLGNRHlPs............plpps..........clhl.........hDtll.cchLcp..................................L.G.................hss.pctct..Fpstttsh..............................................sHsH....................................s................................................................................	0	59	142	201
+4889	PF01730	UreF		UreF	Bashton M, Bateman A	anon	Pfam-B_2037 (release 4.1)	Family	This family consists of the Urease accessory protein  UreF. The urease enzyme (urea amidohydrolase) hydrolyses urea into ammonia and carbamic acid [2].  UreF is proposed to modulate the activation process of urease by eliminating the binding of nickel irons to  noncarbamylated protein [1].	20.50	20.50	20.50	23.20	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.52	0.71	-4.08	171	1651	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	1481	11	435	1261	476	150.00	22	63.76	CHANGED	hVpc..tsslpsWlpshLppshspsDsshLttsac.uhtt.........sDh......ttltplsphhhAtptotEhRtpspphGtuhhclhsp.......................h.tts.....ssh.................................................sasluauhsutthslshppsltuaLauhlpNhlsAAl+llPLGQssuQclLtpLps....h	..........................................................................h.lpcttshttalpthLp...phs.hs-t..hhlt.tsac...Ah..tt.............................sDh.......ttlhclsphhhAp.p..s.cEhRttspphGpph..hcl..htph.....................................htp.thtptp...........sps....................................................................shslshuhhut..............thuls.........hcpsltsahauhspshlpAAlRhlPLGQhsuQcllhplt..h..............................	1	117	257	356
+4890	PF04115	Ureidogly_hydro		Ureidoglycolate hydrolase 	Wood V, Finn RD	anon	Pfam-B_9183 (release 7.3);	Family	Ureidoglycolate hydrolase (EC:3.5.3.19) carried out the third step in the degradation of allantoin.	20.60	20.60	20.60	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.42	0.71	-4.90	81	1067	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	957	8	269	684	700	164.00	40	89.59	CHANGED	h.pp..lp..scPLTt-AFAPFG-VI-s.p................uss.......shhINpGpstRaH-lApl-s.s........su+shlSlFcu.pPpsLP...............................hplchlERHPhGSQAFlPlss.ps..................aLVVV.As..ss.............................................................ssss.sph+AFlssssQ....GVNYt+GsWHtsLhsLs....tsucFhVV......DRh.Gs.....us...Nh-Ehhhsp.shtlp	.................................................................h..pLpl.PLopEAFusaGDVIEs..p..........................ttc...........hhhIN.sGhspRaH.DLAhl-hht...................psRslISlhRu.pP.ts.hP.................................................lslchLERHPhGoQAFlPhpu.cs...........................................FlVVV.A....s.s..............................................................-tP.c....uslRAFl..ss..GpQ....GVNYc+sVWHH.PLhuhp....pssDFlsl........DRu.us.........NC-..ths.......t..................................	0	68	139	207
+4891	PF01014	Uricase		Uricase	Bateman A, Griffiths-Jones SR	anon	Pfam-B_1333 (release 3.0)	Domain	\N	25.00	25.00	26.00	25.80	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.72	0.71	-4.09	122	880	2012-10-01 20:59:24	2003-04-07 12:59:11	13	3	380	220	499	906	5	136.40	24	88.46	CHANGED	php.GhsslplLKss...........+hosh...pc+lhpssVssphph.....t..t.sh.hpucs....ssh..shsss..................pcsoltsaAt.......ssSlpphhhphupchL.sphsp.lpslplplssp+ahc...l........sh.pG...........................cu.lhtsscp.puhlps	..........................t.hp.GhsslpVlKss...........+.ssh...tccl.hshsVssphph..................p..htt.sh...hpucs......ssh...shscs..................p+sslhsaAt..s.....ssSlp..phhhplupchL..sph..sp..lppsclpls.s.tcahp..h.......................sh.tG...........................t.....scu.lhhsscp.hs.lp...............................	0	154	286	410
+4892	PF01208	URO-D		Uroporphyrinogen decarboxylase (URO-D)	Finn RD, Bateman A	anon	Prosite	Domain	\N	23.90	23.90	23.90	23.90	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.88	0.70	-5.52	173	4750	2012-10-01 21:20:02	2003-04-07 12:59:11	12	17	3576	28	1416	3843	3275	317.70	30	91.34	CHANGED	ht.........pcthlpAhpG.cs.s-..........+sPlWhMRQAGRhlsEYpth+t..stsah-hs.psP-lsuElolpPhcpas..hDAuIlF.....uDI.ll.scAhGh.plphhp.sp......G..Phlt....pslp..........s....p-...lp..pL...........ph.ts......t..lshVh-ulphl+c....cl.....ss....clPLIGFsG...uPaTLAsYhltGtssp..shpph+phha......pcPchhcp.Llchls-sshpYlpsQl.cAGAp...slplFD....oauuhLuspp....accaslPah.p+lhstlcphh...............thPlIhaspGs.....s...hlpths..c....sG.s-...s.lul...................Dhps.......sl....stsp..........................................ph.....slQGNlDP.shLh....us.ctlcp.......cspchlc...........httttsaIhNLGHG...lsPpsss-slpthl-sl+ph	.....................................................................................................................h..pphhlcAhht..p...ss...................hsPlWh...MRQ............AGRhh..........PEYpth+t...ths..hh.ph.s....pss...-..l..ssE...lT.l..pPlcpas....hD.A.A.IlF.............SDI..hs...p.u.h.Gh.sl...th...t..ut..........G......P..hh.p......pslp........s..........htD....lp....pL...................................t..ss..............clshVhculchl+c...........cl......tt..........................cl.P...L.I..G...F..s.G.........u..P..a..T......L.A.s.Y.hl..EGts.........S+sapph....+.t.h.h.a......pcP.p....h...h+t.L.Lc.pl.scssh...t...Y.Lp........s...Q......l....c......A......G...A.p.................u.l.l...FD.............oW...u..G....h....L...s....s.......ps..............a.ppFsh.sah.p+l.l.stlp..ppts............................PlllF.s.p.Gs................u.t....hlp.ths.....p........sG..sD.......s...lG...l.....................D.W..p..s.........s.l......cstc......................................plu..sphsl...Q.G......N.h..D...P......s.h.Lh....u....s........p...t...l.cp..................clppllp...........hststG.alh.NLG....H..G...l...h..s..p...ss..sE...plpthlctV+p.h..............................................................................	0	553	997	1240
+4893	PF01175	Urocanase		Urocanase	Finn RD, Bateman A	anon	Prosite	Family	\N	23.20	23.20	23.20	23.50	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.66	0.70	-6.47	57	1993	2009-01-15 18:05:59	2003-04-07 12:59:11	13	6	1787	16	520	1576	698	525.80	53	93.68	CHANGED	.l+....As+G.....spLs..sKuWhpEAshRML.NNLDP-VAEcPc-LVVYGGhG+AARsWpsa-tIlcsLccLcsDETLLlQSGKPVGlF+THtsAPRVLIANSNLVPcWAsW-cFpcL-ptGLhMYGQMTAGSWIYIGoQGIlQGTYETFstsuRp+aG....G........sLpG+hhLTuGLGGMGGAQPLAssMsGusslslElDpsRIc+RlcptYLDchscsLD-AlthhccApppt.cslSlGLlGNAA-lhscLlcR.....Glh.....PDlVTDQTSAHDPlp.GYlPtGhol--hpchpp..p-P...pthhptucpShscHVcAMLthpptGs.sFDYGNNIRphAh-t.Gl..csA...........FcaPGFVPAYIRPL.FCcGhGPFRWlALSGDP-DIh+TDptlhELhP-sc+L.............ppWlchAc-+ltFQGLPARICWlGhG......-Rt+hGLtFN-MVtsGELpAPlVIGRDHLDsGSVASP.RETEuMtDGSDAluDWPlLNALlNsAuGAoWVSlHHGGGVGhGhS.HuGhVlVsDGT-tAscRlpRVLssDPuhGVhRHADAGY-tA.hpsA+-.ps........lclPhhp	.........................................h.l+A.pGsplp..sK..uW.sEAshRMLhNNLDP-VAEpPc-LVVYGGhG+AARNWpsa-tIlcsLcpLpsDpTLLVQSGKPVGlF+THpsAPRVLIANSsLVPcWAsW-+Fp-L-ppGLh.MYGQMTAGSWIYIGoQ......GIVQGTY.........ETFspsu.RpHas........................G......sLpG+hhLTuGLGGMGG.AQPLAushAGusslslEsDpoRI-hRlcptYl.Dchsss.LD-ALshh..................pctpc.pt.cslSluLhGNAA-lh.cllc+........slp.....sD.llTD..QTSAHDPls.G.YlPtGhohE-hpphtp...p..D..P..pthhctucp..SMspHVcAMLshppt.Gs.sFDYGNNIRphAh-.t..Gl..csA...................FcFPGFVPAYIRPL.FCcGhGPFRWsALSGDP-DIh+TDttsp-.lhs.-.s.c+L............................apWlchAcE+ltFQGLPARIsWlGht...........................pRt+lGLAFNEMV+sGElp.APlVIGRDHLDsGSVASPNRETEuM+DGSDAVuDWslLNALlNoAuGAoWVSLHHGGGVGMGaS.HuGhVlVsDGo-cAscRlpRVLtsDPusG..VhRHuDAGY-hA.lcsApE.ps........lplPh..t...............................	0	165	289	419
+4894	PF02083	Urotensin_II		Urotensin II	Mian N, Bateman A	anon	IPR001483	Family	\N	18.60	18.60	19.30	19.30	16.80	15.80	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.31	0.73	-6.26	0.73	-4.32	8	70	2009-09-10 16:31:46	2003-04-07 12:59:11	10	1	37	0	27	66	0	11.70	67	10.48	CHANGED	ssss-CFWKYCV	.....tsps-CFWKYCV	0	2	5	12
+4895	PF02393	US22		US22 like	Bashton M, Bateman A, Zhang D, Aravind L	anon	Pfam-B_1016 (release 5.2)	Family	US22 proteins have been found across many animal DNA viruses and some vertebrates [3]. The name sake of this family US22  Swiss:P09722 is an early nuclear protein that is secreted from  cells [2].  The US22 family may have a role in virus replication  and pathogenesis [1]. Domain analysis showed that US22 proteins\	      usually contain two copies of conserved modules which is  homologous to several other families like SMI1 and SYD (commonly  called SUKH superfamily) [3]. Bacterial operon analysis revealed that all bacterial SUKH members function as immunity proteins against various toxins. Thus US22 family is predicted to counter diverse anti-viral responses by interacting with specific host proteins [3]. 	35.00	35.00	35.10	35.00	33.50	34.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.58	0.71	-4.10	36	718	2012-10-01 20:46:44	2003-04-07 12:59:11	11	4	53	0	8	635	0	131.60	19	44.51	CHANGED	sttshtslpphsccppGpplslstst.....thhlhlsshpshh..............tttthpphttthl.spspphhllGhlsp..s............................................................................................................hsphllllsptGpVYsacs..............cplahlA.sslppFhctGlhphtthh	...................................t...s.ttlpphlpchpGpplsLthPt.....shhlhl.s..stpphh...................stphhpphhpt..hh.s..tsp....th.hslGslsthts....t......................................................................................................................................................................................psphl...llls.ptGpVasac.s.tp..............sp.lahlA.cslppah+.hGlhph....h..........	0	3	3	8
+4896	PF00577	Usher		Outer membrane usher protein	Bateman A, Desvaux M, Eberhardt R	anon	MRC-LMB Genome group and Prosite	Family	In Gram-negative bacteria the biogenesis of fimbriae (or pili) requires a two- component assembly and transport system which is composed of a periplasmic chaperone and an outer membrane protein which has been termed a molecular 'usher' [1-3].  The usher protein is rather large (from 86 to 100 Kd) and seems to be mainly composed of membrane-spanning beta-sheets, a structure reminiscent of porins. Although the degree of sequence similarity of these proteins is not very high they share a number of characteristics. One of these is the presence of two pairs of cysteines, the first one located in the N-terminal part and the second at the C-terminal extremity that are probably involved in disulphide bonds. The best conserved region is located in the central part of these proteins [4-5].	18.90	18.90	19.70	19.00	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.58	0.70	-5.79	34	6892	2012-10-03 17:14:37	2003-04-07 12:59:11	15	21	937	10	466	4642	66	502.70	31	67.01	CHANGED	ahshpsGlNlGsWRLRsss..oaspspsp...........ttpappsphaLpRulspL+ucLslG-shTsuclFDohsFpGspLsSD-sMlPss.RGaAPsl+GIApo.sA+VTlcQNGhlIYpphVPPGPFpIsDl.sssss...GDLpVplpEpDGshppasVPhoolshhhR.Gph+YslsuGchcss......sppppsshFhpuohtaGLstshTlYGGshhup.cYpuhuhGlGtslGshGAlShDsTpupuphsspp.....scpGpSa+hpYsKshstssTslplsuYRYSocsahohs-hl.sp........................phphsp+..sphplsloQsl.us.....usl.lsssppsYW..........tssssspphpsuassshts.lsholshShscsptpppt.....DptlulslSlPhsph.s..............hhuohshspspsupss.psGl.Gshh.cpphsYslptuhsssspps....sshshsapushuplsuuhsasps...pphshulSGuhluasp.Glshupths...sThsllcssG.suGstlss....uspTDhpGhuVlshhssYppNplslDsssLPssl-lppsstpVlPTcGAlVhspF	..................................................................................................hthpsGlNlGsWRlRsps..s.a.spss.sp.......................tpap..ptah....pR....sl.slp.upL.tlG-.s.h..o.s...u...s..l...F.D..o.hs.a.p.GspLtoD.cpMLPss.pGa.APh.l..pG..lA.p...o..sApVolpQNGhhIYpotVsP.GsFtIsDL..sssss.....................GDLpVslcEsDGp..ppa.plPa.uol.P.hh.R.Ghh+Ysl...ssG....ch+st...............sttp.p...ps.Fhpush...aGls......s.shT...........h..Y......G.Gh.......hu...p..pYpuhs..hG.h..Ghs..h.......h.G..A.lShD.sTpup.u......p...h....s.s..tp.............p.pG.....p.....Sh.....R.h..t...YsK...p..h....s...p...o...s..T...sh..p....l.s..u..YR....Y.S.o.p.s.a.hshs-hh.tp.t..............................................p.ths..p..+......sphphslsQ.sl..st........huolhl.o.h..s..p..p.........s.YW..............sss....s..pspph.phu..as.s.....s..h.....t....t.....hs..h..ol......uhs....hsp.....st.....pppt......................-phh...l...sl....Sl.Phsth......................hohs.h..s.p.s..p.p..u..t...s.s.p...p..h.ulsG...shh....s...s...p...h...sYs..lpt.uhsp..p..sspss.........ssushsap.us...h..up..h..ss.......u....h......s....h.....s....p.....s..........p.........p..hs....h....uh......s..........Gul......l..s..a..st..G.ls.h..u..p..hs...........-Thsll.c.......A.....s.G...s..t..s..s........l......p.....sp........sstTs..hh...G...huVlshhosYppN...plslDss.s.l....s.s..s.s-l.pp.s.s.tp.lsP..s.c..GAlshspF...............................................................................................................	0	58	144	319
+4897	PF04871	Uso1_p115_C		Uso1 / p115 like vesicle tethering protein, C terminal region	Kerrison ND	anon	Pfam-B_6073 (release 7.6)	Family	Also known as General vesicular transport factor, Transcytosis associate protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [1].  p115  tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal  acidic region.  It is required for intercisternal transport in the golgi stack. This family consists of the acidic C-terminus, which binds to the golgins giantin and GM130.  p115 is thought to juxtapose two membranes by binding giantin with one acidic region, and GM130 with another [2].	22.20	22.20	22.30	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.88	0.71	-4.23	6	224	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	191	0	157	229	1	127.70	25	12.86	CHANGED	tclpsEuptppshAAKhh-h-s+h.tph.suLtQtpppLcpE.....hKuLpt...s..t...tcsspphsplcslKpcLctE.........u.p-ucsEh-DLLlLLuDp-pKlp+hcu+Lp-LGh-V..--......tD-u.tsp--D--E	.........................................................................t...............ttt....-.p.....ph...............s..t.L..p.t.p.pp..hcpc...................hctLp....c...t.....p.....t....thp.pp...h........pptpsp..h.s..t..........L.p.s.t+pc...L..c...t.E................................s.p..c..s..cp....E.-DLLlLLuD.-pKlpphKp+LK-LGp.pVp---........t.p..--p.-cppt....p.............................	0	37	75	124
+4898	PF04869	Uso1_p115_head		Uso1 / p115 like vesicle tethering protein, head region	Kerrison ND	anon	Pfam-B_6073 (release 7.6)	Family	Also known as General vesicular transport factor, Transcytosis associated protein (TAP) and Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [1].  p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region.  It is required for intercisternal transport in the golgi stack.\	This family consists of part of the head region. The head region is highly conserved, but its function is unknown.  It does not seem to be essential for vesicle tethering [1].  The N-terminal part of the head region, not within this family, contains context-detected Armadillo/beta-catenin-like repeats (Pfam:PF00514).	25.00	25.00	27.70	25.80	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.77	0.70	-5.67	26	295	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	240	4	205	303	1	289.20	30	29.08	CHANGED	GNtphQppFuplsV........s.h-...ss.........s..lsVl.sLLphhLt.ssh...psaDlRsAushClcuYhhsNpphptpFLpptIsuapsss..............................................s.psN....lhssLht..p.ph..sh-PYphWFuullLhHllh-sscs....KphhhpV......t..pGspssGE-slosIQs...........loslLlsslp.spD....................RlslGYLMLLssWLac-.sAVs-FLu-toslpsLls......sppssspsslVpGLsuhLLGlsYEFS.opsSPhsRtcLapLlhpplGp-sYhsKlppl+cpslapchp...psphshs.cp..tLP.........-laFDphFlcLhK-sasRlp+Al	................................................................................................................................st..Q-.Fuplps..................................s...ss.shsslssLLh.hlpp..p.............pshslRsAshhChps..ahhcNppsptpllps..h...lsuphsss..........................................................sthss..........lhssLh................ssDs...hps...Wh...AuVhLhHhl.-sspt....Kc.hhcV..................................phss.s.......G..ptslo...hlQp............hs.shL..p.....t....s.sc...............................................phplGhLhLLssWLhpss.AVscFLp..............psuslthLhtt............spp.s.p..pc.ll..pGLsAhLLGlsh.Fs.sp...s..s................hs+p.....plpplltpRlGp-pahp+lstlpcp.hapchp.........p.phstsp......................................phhFDppFschhKc..uhlh+ul...............................................	0	68	111	170
+4899	PF00582	Usp		Universal stress protein family	Bateman A, Griffiths-Jones SR, Kerk D, Studholme, DJ	anon	MRC-LMB Genome group	Domain	The universal stress protein UspA Swiss:P28242 [1]  is a small cytoplasmic  bacterial protein whose expression  is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during  prolonged exposure to such conditions, and may provide a general "stress endurance" activity.  The crystal structure of Haemophilus influenzae UspA [3] reveals  an  alpha/beta fold similar to that of the Methanococcus jannaschii  MJ0577 protein, which binds ATP [2], though UspA lacks ATP-binding activity.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.68	0.71	-3.99	231	22843	2012-10-02 18:00:56	2003-04-07 12:59:11	21	106	4199	94	7308	17012	1965	137.10	18	62.93	CHANGED	hhc+llVuhD..soppup.pAlphAhp...hupp..tstlhllaVhsstshtttsthhttttttthttttt..................................t.thhthphhhhtssssptlhphscptss-llVhGspu............hsshpc.hl...lGS.ssppllcpuss..PVll.l+	.........................................................................................................................................................pplllsl..D.........so.pp.....up......p....u....l..c..tAhp...........................hApp........s....u.....p....l...p.l....l....p..l.....h......s......s.........s.....h...t....h......s...t.....t..h....t......h.....t...h...t...t...t..h.t..t.t.t...t.tt.............................................................................h.t.t.h.s.t..h.....p..h..h...l.......t.....t.....u.....s.....s....t.....p....s....l.h..c....h.............s.........p.....p....t.......s..........s.........-.......l.lVhG.sps.............................ts.s..hpp..hh..............lG.S...su..ppl.l.p.....p...u..p..s...sVlll...............................................................................	0	2051	4696	6329
+4900	PF03253	UT		Urea transporter	Bateman A	anon	Pfam-B_3193 (release 6.5)	Family	Members of this family transport urea across membranes. The family includes a bacterial homologue Swiss:Q9S408. 	25.00	25.00	26.30	26.30	19.50	22.30	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.92	0.70	-5.53	26	784	2009-01-15 18:05:59	2003-04-07 12:59:11	9	9	618	6	188	566	13	275.00	32	84.53	CHANGED	phl.....-hlLRGluQVhF.NNPlSGLlILhulhl.....psshhulsullGslhSTLoAhllstc+utIssGLaGaNGsLVGlhluhF.sh........hsh.hhhlhhsuhhssllsuu.LtslhspaclPshThPFslsshLh..lhust+hs.h.st..h........pPssstss.shsthsls..phlpulhhGlGQVahpsNsloGhlhLlulhlsS.lhslaAllGSslGhlsu.LhlusshsslhtGLaGaNslLsslAlGuhFhhhshpotLhulhsslhsshltsulu.hhtslGLPshThPFslsoh.hhLlsssphphhc	........................hlchlL+uhuQVhh.sNshoGLhlLlulhl.....ss.tl.uluuhlGollushhAh.......hls..h......s..c.............s.pl..psGLhGa...NusLsulslslFhst.............phhhlhh.shluohhsshlssA.lp.p.l.....h.p.....a.....clPshThPFllssW.hh....lhh..ssth.phh....sshhh..................hPt......tss.....h.s..ph.ph..................phlpulh.GhuQVahts.s.s.luGllh.llGlhIsShhsulhAlluShluhhhs..hhL.....uu....s...............hss.....It.tGLa..GaNslLsuIAlGshF.t..s.h..p.shlhslh....u.s.lho.sh.lp......huh......sshhtshGlP.shThPFllsoW.lhLhss......................................	0	43	66	119
+4901	PF01099	Uteroglobin	Uterglobin; 	Uteroglobin family	Finn RD, Bateman A	anon	Prosite	Domain	Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be  elucidated [1].	24.80	24.80	25.10	24.90	23.80	23.30	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.16	0.72	-4.17	32	271	2012-10-01 20:54:19	2003-04-07 12:59:11	12	1	46	12	118	280	0	65.00	24	72.61	CHANGED	Cssltphlpthl.s..o.spYct.LppapssstshpAttplKpCsD.phopcs+tpltphhtpIhpS......hC	................Cshh.phlpthl.s..o.stYcthLppasss.tshpAhtplKpCsD.pls.c.s+tpltplhttlh...................	0	9	9	22
+4902	PF03998	Utp11		Utp11 protein	Bateman A, Wood V	anon	Pfam-B_6404 (release 7.3)	Family	This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA [1]. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome [1].	25.00	25.00	26.30	25.90	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.92	0.70	-4.55	50	346	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	301	0	243	331	3	230.20	32	92.06	CHANGED	++sH+ERuQPpsRp.+hG.lLEK+KDYphRAcDY+cKpppLKtL+cKAtp+NPDEFYatMhssKssc........Ghthtppt.....spthoh-pl..+LhKTQDhsYlcpptps-t+Klc..+hpppL..h..s.tsps................................................+HhlFsDscc-.pphp.tph........................possphlscpps+..p.ptlpt..h...........................t..pphpppptpphppLpp+hpRpcpLpplppchphp+clh..ppt..ppp+lhtsp..............................sssha+a+tpRKR	..............................p+pH+ERuQPttRp.+hG..lLEK+KDYphRAcDa+cKpppL+tL+cKAtp.+NPDEFYatMhss+sps...........Gh+htppp.................................pcpho.-.pl........+Lh+TQDhtYlchptpt-t+Kl-.+LpppL.....th.hsht...sps...................................................................................+HhhFsD.s.cc.......Ehc.p......hp.tp.hh...........................pstsphhsct.sc........phppltp...............................t.tthpphtcppppphppLpp+hpRtppLthhtpchp..hp+thh..........t.t.....phh+h..h.tt.t...............................................t.shahahtpRK+...........................................................	0	84	134	201
+4903	PF04003	Utp12		Dip2/Utp12 Family	Wood V, Bateman A	anon	Pfam-B_10105 (release 7.3)	Family	This domain is found at the C-terminus of proteins containing WD40 repeats.  These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2 Swiss:Q12220 [1].	26.00	26.00	26.00	26.00	25.90	25.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.08	0.72	-4.15	96	902	2009-01-15 18:05:59	2003-04-07 12:59:11	7	30	298	0	660	885	5	107.30	20	13.59	CHANGED	s-pphlppll.pslssspIctsltpLPhsal.pLLchlsphhp.pps.....+lphhhtWlphllptHup.lssp...........................plhspLpslpphlppphpplpclhshN.ttLphLtsph	...................................ppphltpsl...pslss.s.plcpslt...pLP.h...........s.....hl.p.LLphlsphhp..pp.s................clphh.ht..WlphlLphH.ushlssp...........................................p.hhstLpsLpphlppphpplp...clhshN.ttLphlht..h..........................................................	0	207	353	543
+4904	PF04615	Utp14		Utp14 protein	Bateman A, Wood V	anon	Pfam-B_5404 (release 7.4)	Family	This protein is found to be part of a large ribonucleoprotein complex containing the U3 snoRNA [1]. Depletion of the Utp proteins impedes production of the 18S rRNA, indicating that they are part of the active pre-rRNA processing complex. This large RNP complex has been termed the small subunit (SSU) processome [1].	21.20	21.20	23.80	21.60	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.68	0.70	-13.55	0.70	-6.37	39	482	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	291	0	309	487	11	532.10	22	84.48	CHANGED	sS--...............................ps-pp.....--cchpcLhshlssLspcscp......................pp+pttsptptp.sEFsl.....sopst......KLslsDL.lsslp....ssphppstKtLsphppspp.........LcsPLsKcpQ-Rl-RpAAY-popcpls+WpssVppNRcAEpLhFPL....t..sstssshsphhsshpPpT-LEpcltslLpcSsLs.............s-cphsphE.-lphpchohEEh+tRRsELp+hRpLhaRcEtKAKRlKKIKSKsY++lc+Kc+t+...pp.pptLhcsss-tuc--hpch-cpRApERMoLKHKssSKWAKshhp.GhuphDp-sRpuhpE.LppsccLp..cKlpupp.sctspc..ssps.p-s.-cp........t.ps.pththppchpchtt.t..t............stlhshpFMpsuEscc.+cpscpEhctLp......cEhct.-stppc.t.................tppp.GRRpau.....ttpt.sppttppsppphcpthts-cppt.tsc.ptphppt.s........................tpspptpptpcppssscpNsahppspppspssppptpp.................tp.s.t.tpht.t...........ppcpKpppsstschhhspsp.............................sppp---tp.s..........hcpp-lIpc......AFAGDDVV.t-FppEKpcslcc-ssK.-lDhTLPGWGsWuGsGlppp...p..p...++hltKsctl.phcpRKDppLppVIINEK.ps.KKss+a.sspLPaPFco+pQYERSlRhPlG.-WsocpoaQchT+PRVlsKtG.lIcPhctPh	...............................................................................................................tp...................................................................................th.t........h................................................................................................tl.ltph.h..ht..........t...t.....t.hp....h....t..t.ttt....................................lt.h..PL.p........pc.hpRthsht.spp.ht.p.W..hl.........ttc..........putp.l.Fs..................................................h....t..s..ts.hptpl...thh.tst........................................t..c......hthtt...hs..cEhh....+ptc...hthhRtl.....h.ph+u+R.pKIKSKta++lh++t.c.+.............................................pth.......t..ss.........t..s.p.h...t.-htRh.ERhsh+Hp..p....upWA+ph.....hst..c.p.sRttht-...h...thtccLp..p+h..................t.tpt....p.........t..............................................t...h.tt.tt.................................................tt..t..hhpts.ttt.....tt..t.t.t.h......................pp.pt....pt..tt..............................................p.tcp.....t..................t..........t...t..p....tt..............t.......................t.....................................................................................tt..........t..........tt.h.ttt........t...............................................................................ttptp....t...t..p.....t.t...............................................................tt.ptp.t......................................pppthltp......AF.....s...s.D..-l..t-F.p-Ktp...pt....pts...........p.......h.....s.........s..L.PGW.Gp.WsG.s....hp.p......................p+.hh+h..............R+Dtph.pVII.s.E....c..hs..h...............p...tth.sp.lPaPap.p.t.paEtshphPlG.passttshpthhtPpl............hh+.G.lItPhp...................................................................................................................	0	127	183	260
+4905	PF03851	UvdE		UV-endonuclease UvdE	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.10	20.10	20.30	20.20	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.82	0.70	-5.38	6	508	2012-10-03 05:58:16	2003-04-07 12:59:11	9	6	393	5	182	475	377	265.00	34	70.05	CHANGED	hGYVshshtLtsspPshThotTphhphtccEt.............................cpLhclspsNl+shl+hLcaNhuasIphaRLSSslhPhAoHP..chGachhshhsppLpElGclss-ashRlohHPsQFTllsSs+ccVscsAlpDhsYHh+lLcuhtls-p....ulllIHlGGtatsKcssl-cF+cNhtcLPpslKpRlsLENDD+oYTsp-lLslCEchsIPhVhDaHHHsls.....hccssL-.sh.....RIhpTWp+pslp.KlHlSsPtsspshps+p-hhcuchlhsF.pph	..................................................................hGYss..hs..hhL.hs.s.sP...s.tho.hsp.htph.t.cp.c.t.............................c+LpclsppNLcshl+lL+aNhs.a..s..IphaRlS.S.pllPLAoHs........ht...a.....sa.....h.....t...........h...p...pthpclG....ch...spchshRlohHPs........QF.slL.sSsc.c.l..hpsulp-LpYHtchLc.shG.lspp.....shhslHlGGs.Y.G.s...Kctul....-R.FhcNa.p.p.L.....s.p.....pI...+c......plsL...EN.....DD...p..o......a...o.....hc-sL...lscc...h......s..I.PhVaDhHHHhhs..........................pcps.hc.hh...........plhp...TW.........p...........p..........p.sls...s.KhHhSsP+st..t...t.psHschhc.phhhsh...h..............................................................................................	0	65	119	156
+4906	PF00580	UvrD-helicase		UvrD/REP helicase N-terminal domain	Bateman A	anon	MRC-LMB Genome group.	Domain	The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.06	0.70	-5.13	36	18162	2012-10-05 12:31:08	2003-04-07 12:59:11	16	135	4762	24	4265	16492	6532	265.50	23	35.17	CHANGED	LNspQppAlpt...hpushLllAGAGoGKT+llspRlsaLlpppt..lsPpp........ILslTFTNKAApEM+cRltp...................hltpt.........................hcthhluTFHohshclL+pphppls.......................hppsFplhDppD..................................phtllcclh......pt.hshstchhp............................................................................................................................................................thpthlsphKsphhpspphtp.................ts.htp.htphappYppphpppsh........................................................................................lDFsDLlhhshp..................................lhpp.............spplhpphpp+a+alLVDEaQDTNthQYpll+hLsspptp...........lhlVGDsDQSIYuaRGAclpNllphpc-as	..............................................................................................................................................................................................................................................Q.t.s..h.............tt.....s....h.....l..l...Au...........A.GoGKT.t...s.l...s...t....+........h....h.h.l...l..............tt.............h.t..s....t.p..........................................ll.slTFTp....t..AAt..E..h.c...pR...ltp..............................................................................................................hh.......................................................................................t.....t...h.hl......t....T.h.....H...u..h...s......p..h....l...p...t........h.......h.s............................................................................................................................h....t..h.p..h...pttp.....................................................................................................................t.h..h..t....thht...............................................t......h............................................................................................................................................................................................................................................................................................................................................h...........h....h...p...t........p.....p...t...h..h..............t.h...t...............................................................t..............t...h...h...t....t....h......h.....p....t......a....p....p....t....h....p....t....t..s..h....................................................................................................................................................................................................................lD.F..s..D...l...l..h.h.s..h..p.......................................................................................hh.pp........................................t.l..h...t...t.h..p...p...p....a...p.hlhl.DEa.QD.o.s...h.Q.h.t.....l....l.....p.....h....l...h.....t...t...t...tp............................................lh..h..V.GDscQuIY...s....a...RGA.p..p...h.t.h.pp...................................................................................................................................................................................................................................................................................................................................................................................................	0	1443	2832	3657
+4907	PF02614	UxaC		Glucuronate isomerase	Bashton M, Bateman A, Eberhardt R	anon	COG1904	Domain	This is a family of Glucuronate isomerases also known as D-glucuronate  isomerase, uronic isomerase, uronate isomerase, or uronic acid isomerase, EC:5.3.1.12.  This enzyme catalyses the reactions: D-glucuronate <=>  D-fructuronate and D-galacturonate <=> D-tagaturonate.  It is not however  clear where the experimental evidence for this functional assignment came from and thus this family has no literature reference.	25.00	25.00	25.70	25.50	22.20	20.60	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.57	0.70	-5.87	42	1495	2012-10-03 00:45:34	2003-04-07 12:59:11	9	6	1344	79	293	1024	317	436.20	44	97.60	CHANGED	Mp.hhsc.sFLLs.scs...AcpLa+chApshPIhDYHsHLsPp-Ih-s+hapsls-lWLh....GDHYKWRhMRtsGlsEphlTG.susshEKFhAaAcTl.hshuNPlYcWoHLEL+R............hF...Glst.hlspcsAspIWcpsNthLt.s....sshpscplhppuNVchlsTTDDPhDsLchHptls.t.....cpsh..hpVhPuaRPDcslplct.psassalcpLutssshplpshsshhpALcpRhcaFcphGschuDHuls.phhasc.ss..phpthhtph.hssp.hottp.tpapohlhhhLsphhpcpuashQlHlGuhRssNsthhppLGsDsGhDSlsc.s..spsLppLLsphsppstlPKhllYsLNPp.sshhluohhssFp..tt.h..plQhGuuWW.....FsDs.tsGMhcQhpphup.uLhosFlGMLTDSRSFLSY.sRHEYFRRlLCsllGchlE....pGphPs-tphlschVcDIsasNuccaF	..........................................................Mt..Fhs-.sFLLp.s-hA+cLYHcaAcc.PIhDaHCHLsPppIA-.s.hpFcNlsclWLt.............GDHYKWRhM.......Ros.......G.......V..........s..........E.....c.....h.....h........T.....G.......-..........u.....o.....D....hE....K.......FpA.W...ApTl....P...pslGNPL.YHWo.HLEL.+R...............sF.....GIst....lLuspoA-cIasp.sN-h.Ls.p....ssFosRu.lhpp.hNVchluTT..DD.PlDsL-aHtplut.........Dsuas...h+VlPoaRPDKu.hs.....I.-t.ssFsca.l.t.+Luclus.s.s.Ip...passhhp.ALpcRh-aF.st.p.G.C+.sSDHul-...slhasp.......s.........s........-s..clcuIhs+t..luG.p.s..l.......opc.Ehs.pF+oslLlhLut..YtccGWV.Q.hHhGAlRNNNt.chFchLGsDsGaDSIsDps..huptLs+LLsphspps.LPKTILYsLNPp.DNcsluohhGsFQ......stuh.....s.GKlQaGouWW.....FNDp.+-GMpR......QhppLu.phGL....LSpFVGMLTDSRSFLSY.sRHEYFR.RILCphlGchVp....sGEhPs.D..sh..L.uchVpsIsasNAppYF.........................................	0	103	204	246
+4908	PF03786	UxuA		D-mannonate dehydratase (UxuA)	Finn RD	anon	COG1312	Family	UxuA (this family) and UxuB are required for hexuronate degradation.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.21	0.70	-5.89	10	1615	2012-10-03 05:58:16	2003-04-07 12:59:11	8	7	1348	10	330	1058	320	354.40	48	97.28	CHANGED	MchsaRWaGstsDsVoLpcl+Ql.GVcGVVuALacIPs.......G-lWshEcIhchKcpIEsuGLslsVlESVPVHE-IKlGsssR-+YIENYKpTIRNLAcsGI+VlCYNFMPVhDWoRTDLphcLsDGSpALtF-cpclsshsPp..lh+p.sustsas.............................LPGhE.ph.Lsph+phhptY+cIDpEcLa-NLuYFLccIIPVAEEsGVKMAIHPDDPPaP.IaGLPRIVost-shc+llchsDSPsNGIThCoGShGspssNDls-MI+cFuc..RIaFuHlRNlKtp..sscsFhEouHhs..GulDMhslhKAhh-psacG..........hhRPDHG+plaG-p....spPGYuLhsRhhGluYlpGLa-Alpp	....................................Mc.TaR.WYGs.....sDPVoLpclRQh..G.soG.lVoAL.H.c.IPs.........................G.E..l.W..sh-EIhchKthl......E.......s...........s......G......L.pasV.........VE....S..V.P..l..H..E....-....IKtt.s....s....s.h-paItNYppTLRNLApsGIcsVC...YN..F..M..P.V.hDWTRTDLpa...h.sDGS.puLtFDphp..hs.....uh.-hp...ll..c.p...s.u.p.s-as..................................................LPGhE...pth...tL.......sph+ph..L.....thYc..sIscscLR-NhtaFLcsIlPVAEE...sGl+MAlHPDDPPhs...I..hGL.PR.Iloo..h..-Dh.phhlc.s.V..sS..uNGh.ThCTGSh....G...s...c...s..-N........D...L.ss.hl+p.FGs...RIaFsHlRss......p......t....p.............s........s....p....sFaEuuHLs.......GslDMapllKA....ll....-.p.p.act..........shRPDHG..+ph.hsDh..............tspP.GY....uhhuRhhGLu.lpGl..Alp.t................................	0	117	222	269
+4909	PF03223	V-ATPase_C		V-ATPase subunit C	Mifsud W	anon	Pfam-B_2945 (release 6.5)	Family	\N	23.10	23.10	23.90	29.00	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.06	0.70	-5.54	33	459	2009-01-15 18:05:59	2003-04-07 12:59:11	10	4	321	1	294	434	5	354.10	38	95.30	CHANGED	ahllShPsptsstps.....hpph.hhs.thtsshssstcFslP.-hKlGT.................LDsLlshSD-LsKlDstlEuslpKltphlt-l...psppspltpshhssst................................................................................................................................................................................................................................................................................................................................................................................................................................................................slssYlpp....FpW...spuKYshcp.slppll...-hluppssplDsDl+s+hssYNssKusLpshpRKp...........................oGsLts+sLs-lV+t.....-cFl..cSEY..LsTlLVsVPKs.hp-a.psYEoLoch..............................VVP+Suphls.....pDsEasLasVsLF........................KKsh--FpppsRE+.KalVR.-FsYsEcthppt+pEhschtscccp.h............................................ssLlRhh+ssaS-sFhuWlHlKALRVFVESVLRYGLPssFtuhllpsst...Kst.c+l+phLtphasaLss....suhststcsc..hs.suL...........hsppEYaPYV	...........................................................................ahLlShPsptpstps.......hpp.hpthp...thp.ss..hu.sshcFsIP.-h.K..lGT...................LDsLlshSD-LuKl.DshsEu.....llpKlsphltcl..h.-.ss..........psplpp..phhsN...s...h................................................................................................................................................................................................................................................................................................................................................................................................................................................................slspY.l.p.p....FpW...shuKYsh..c.p.sLppls.................-hlscp.....lspIDsDlKs+hstYN.slKssL.ps.l.pRKp...........................s..G..sLhsRsLs-lVc..................-c...h....V...-SEYLh..TlLV.lVPKtshp..-W.psYEoLssh.......................................VVPRSophls..........cDs-.hsLasVTLF............................+Kss--Fpp+AREp.KFh.lR.-FpYs.Ect....hcpp+cEhs+lts-c+c.h...................................................u..LlRhh+ssaS.....EsFhuWlHl.KAL.RVFVESVL....RYG....LPs..sFtuhllpssp.......................Ks....++l+phLpphataLsu....suhst..hps.....t.....hp.sul.............hspp-YhPaV.............................	0	99	156	232
+4910	PF03179	V-ATPase_G		Vacuolar (H+)-ATPase G subunit	Mifsud W	anon	Pfam-B_1274 (release 6.5)	Family	This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialised cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.	22.90	22.90	23.00	22.90	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.38	0.72	-3.74	34	591	2012-10-02 21:03:42	2003-04-07 12:59:11	10	9	372	2	345	587	15	99.90	33	78.74	CHANGED	upssGIQpLLpAE+cApchVscARct+scRLKQAKpEApcEI-pYRtp+Ep-F+chcspphGs..pssstpcl-p-TppcIpplppssppp+cpVlphLLphVhsl+	........................pppGIQpLLpAE+cAtchVsc.A..Rc...........p......+s......cR.......LKQ.AKcEA.....ptEI.-p..YRtp+EcE.Fc.p.hps.pt..........hGu.......ptshspcl-.p-Tptcl..pplppthppp...pcpVlptLlphVhsl.....................................	0	105	184	265
+4911	PF03224	V-ATPase_H_N	V-ATPase_H; 	V-ATPase subunit H	Mifsud W	anon	Pfam-B_2481 (release 6.5)	Family	The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer.  This domain corresponds to the N terminal domain of the H subunit of V-ATPase.  The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation [3].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.92	0.70	-5.31	37	456	2012-10-11 20:00:59	2003-04-07 12:59:11	9	17	312	1	294	475	12	285.20	24	62.84	CHANGED	shlsphtsplRtp.....lsWpuhhcuphlopcshphl+pl-ph..pp.+tp...hl.ppsss.thsphhl......sllppl...pcp-slpYlLsLlsD.lLsps...thtphhhshtp.tp.p....sapshLp.hhppp.Dthls.h...ushllspllstsshptsp..................chL....thhhsh..Lps...hhss................................................................................pssth...........................hslpsLptlLptcpaRthFhp..scslphLhs.lL...................................................................................sspsslQL.YpsllslWlLSFpsphstphhppp..ll.hLscll+pos..KEKlsRlsluslhNLl...spstpt.........................................hhthhl.sphlt.hlppLppR+a....sD--lh-DlphLp-hL	............................................................................................................................................................................................................................................................ht..ttplhtp.lsWpshhput..hlotpphphlpth-ph.ptp..+tp.........hl..pppss..ths.phhl........slhpph.........p+ppslpYlLshls-..hLpps.....ptsphhhp.tt.tp.t..............at.hL.t...hh.s..pt..-.hh..h......uupllsplhshstp..pt..........................psL....phhhsh..lps.......h.p.s...........................................................................................................................ss.sth..............................phsh.psLphh.L.+hpp.hR.hahp...........ssslp.slhs...lL...........................................................................................................................sspsshQl.YphlhslWhLoFpsthst.p.h..p.t..................ll.hlscllptss...KE.KlsRlhlushpNhl..ppstt..........................................hh..h.l.....spl.t..lp.Lpt.p.+.a....sDtDl.cDlp.L.-hL...........................................................................................................................	0	106	168	246
+4912	PF01639	v110		Viral family 110	Bateman A	anon	Pfam-B_1518 (release 4.1)	Family	This family of viral proteins is known as the 110 family [1]. The function of members of this family is unknown. The family contains a central cysteine rich region with eight conserved cysteines. Some members of the family contains two copies of the cysteine rich region Swiss:P18560. 	25.00	25.00	48.20	48.00	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-11.11	0.72	-4.49	10	107	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	11	0	0	103	0	107.00	40	82.88	CHANGED	llsLLup......hsssptsspL.pTpsPPccELcYWCTYscsCcFCWDCQcGICKNKlhss..ssIhcN-.YlpsChVoRahsp..ChY-lst+I..hHsMsCSpP+sas.saclh	...............h.hhLLu.......hh.ththtpL.tTppPPccELpYWCTYscpCcFCW-CpcGICKNKlhcs.h.shIhcNc.altsCpVoRh...sp..ChY.hss.+h..hH.M-CSpPpsap................	0	0	0	0
+4913	PF03402	V1R		Vomeronasal organ pheromone receptor family, V1R	Mifsud W	anon	Pfam-B_3057 (release 6.6)	Family	This family represents one of two known vomeronasal organ receptor families, the V1R family (after [4]).	25.00	25.00	25.00	25.00	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.93	0.70	-4.99	2	2399	2012-10-03 04:04:29	2003-04-07 12:59:11	9	5	78	0	1464	2009	0	245.10	33	86.01	CHANGED	KLlstp+s+.hDL.IuhLSLhpLhhLlhhuhIAsDhFhsWttWsshhCpSLlYLaRhhRGLuLssoCLLsVL.sIhLSsRSSCLsKFKHKssHHISsAhL.h.VLYM.hSSHlLVSIIsTPNLTopDFhaVTQ.CSlLPMSY.hpShFSTLhAIR-sFLISLMsLSohYMVALLhRH+KQspHLpuTSLSsKASPEQRATRoIhhLhSLFVlh.lh-plVhpSRhhahsssl.Y.hplhMsH.YATVSPFVFIsTEKHIlp.hcS	..........................................................h......p.pshD..l.Il.tHLsl..sNh.l....hLL..o.p.G...l......t..s.....h..h..h..s..h..p.........h...s.....-.h.s.C.K.h.lh.Yl.hRVu.R.GLulC...oTCLL.SlFQAlTI.S.P..ss.S.p.hup.l.K.s.+.h.s..+....h...l...h...s.s.hh.h...h.W.l...l..s....h.h...ls....h.....s..h..h..h...h..h...h...u...s...p....N....s.....o....s..s....s.....h.....h..h..s..h...p.....a..C.s..h....h...s...h....s....t..h....h..p......h..l..h..s...s..h.....h.s.h....+....DlhF.l.u.LM.shu.S..GYMVh.l.L.aRH+..+p.VpH...l..Hss.s.hSs..+..ssPE.sRAs+oll.hL.V.s.haV...hhY.s..h.s...s...l...h..h......h....h..h........h..p..p...p..s...h..h..h..p....h..p..h..h.....h.s.......s.a.sslsPhl.hl........................t..............................................	0	7	20	850
+4914	PF02830	V4R		V4R domain	Bateman A	anon	[1]	Family	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons [1].	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.03	0.72	-4.13	52	616	2012-10-02 19:02:47	2003-04-07 12:59:11	13	22	405	2	314	617	58	62.00	25	18.38	CHANGED	hhhph-sshpttshstsscPlCahhtGhhsGhhs........phhs+p..lhhcEspCtupGss...pCpahsc.	......................phcss.hht.th.st..ss...cP.lC..a.hhsGhhsGhhs.........shhu...pp...lhspEs..pCt.ut.Gcs...pCpFhsp........	0	95	201	264
+4915	PF01496	V_ATPase_I	V_ATPase_sub_a; 	V-type ATPase 116kDa subunit family  	Bashton M, Bateman A	anon	Pfam-B_446 (release 4.0)	Family	This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i.  The V-type ATPases family are proton pumps that acidify intracellular compartments  in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes [1].  The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices  it has a hydrophilic amino terminal and a hydrophobic carboxy  terminal [1,2]. It has roles in proton transport and assembly of the V-type ATPase complex [1,2].  This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [2].	26.50	26.50	26.60	26.60	26.30	26.40	hmmbuild  -o /dev/null HMM SEED	759	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-13.24	0.70	-6.68	16	3017	2009-01-15 18:05:59	2003-04-07 12:59:11	14	11	1209	4	1136	2604	291	408.80	17	89.37	CHANGED	lstLt-lGlVphcDLNpcls.shQRchlp-h+Rts-h-+pLthlppplp+ttl.h...........ptthp.sh...p.........ph.chptphpclEscl+plpcshcpLccphppLpEhtphLcpspphhcpt......................cthp............htsl.hs.pthp.......tsphlcl....................hluGslspc+hsshcchLh+ss+G..hht.hplcpsh.-sp......hpsallhhpucphtp+lc+Is-shthphashs-pptt.p-hlpplppclp-lpphLcpspsplcphlsthtcplhsapphlpp-Kslacshshhshss..+slIhEuWsPtc-lsplppsLccssstsu...lsslhs.hcsp-pPPThh+ssKFspsFQsIs-sYG.lspYcElsPuhhhhlTFPFhFulMhGDhGaGllhhLhALhllhtcpphsstp.........aph+YIlllhGlFSlhhGhlYN-hFucshslFtSthths.......................hpt.sl....t.s......YPhulDshapsss..tl...s.hhhthSlllGllHhsaGlhluhhNthph+...p.hslhtshlspllalhsIhGhh.h.hh.ta.h..h...............sPslL.hhl.MFLhs....s........................lQshLlhhulhslPllllhtPlhlhtpthp...........................t.............................h...hG...h.htpsIasIEh..sLGsluphsSYlRLaALuLApupLSsVl.sMshthsh.hts......slhhhllhshhhllshsl.llMpuLSAhLHuLRLHaVEFhuKF.YpGsGhpFpPFuhp	.........................................................................................................................................................................................................................h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.ha..............h...h............................................................................................................................................................................Ph..t..........ht...hht...h...st..ths......s..h....a..h...............hauhhhsDhu.uh...h.h..h.h.s...h.h.........h......................................................................................................h.h.........sh.shhh.G.hh.h.s.thhu...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.t.hSa.Rlhs..h....hst.................h...h.........................................................hh....h....h.hhht.h...shlps.RL..............h....................hE..t...............t........................................................................................................................................................	0	428	699	955
+4916	PF02346	Vac_Fusion		Chordopoxvirus fusion protein	Bashton M, Bateman A	anon	Pfam-B_822 (release 5.2)	Family	This is a family of viral fusion proteins from the chordopoxviruses. Swiss:P26312 a 14-kDa Vaccinia Virus protein  has been demonstrated to function as a viral fusion protein mediating  cell fusion at endosmomal (low) pH [1].	22.00	22.00	22.00	22.20	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.81	0.72	-4.54	11	335	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	61	0	0	153	1	42.00	54	24.57	CHANGED	.plcslEcRLssLpcpapplhcsC+psscslcRLENHhETLR+uMlsLsKKIDVQTG	.......................QRLTNLEKKITNVTTKFEQIEKCCKRNDEV...............................	0	0	0	0
+4917	PF02691	VacA		Vacuolating cyotoxin	Bashton M, Bateman A	anon	Pfam-B_436 (release 5.5)	Family	This family consists of Vacuolating cyotoxin proteins form Proteobacteria. These proteins are an important virulence determinate in H. pylori and induce cytoplasmic vacuolation in a variety of mammalian cell lines [1].	18.90	18.90	19.30	19.10	17.70	17.70	hmmbuild  -o /dev/null HMM SEED	981	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.36	0.70	-13.81	0.70	-6.90	2	1164	2009-01-15 18:05:59	2003-04-07 12:59:11	10	6	43	1	2	1174	1	244.10	38	85.28	CHANGED	AFFTTVIIPAIVGGIATGsAVGTVSGLLuWGLKQAEpANKsPDKPDKVWRIQAG+GFspFPpKpYDLYKSLLSSKIDGGWDWGNAApHYWlKsGQWNKLEVDMpsAVGTYpLSGLhNFTGGDLDVNMQKATLRLGQFNGNSFTSaKDuAsRTTRVsFsAKNILIDNFlEINNRVGSGAGRKASSTVLTLpuSEtITSpcNAEISLYDGATLNLsS..N.SVcL.GpVWMGRLQYVGAYLAPSYSTIsTSKVpGEhNFpHLsVGDpNAAQAGIIAspKTpIGTLDLWQSAGLsIIsPPEGGYcsKspssP.............QN.......NP.NssQKTElQPTQVIDGPFAGGKDTVVNI.+lNTKADGTl+sGGFKASLoTNAAHLpIGcGGVNLSNQASGRTLLVENLTGNITV-GsLRVNNQVGGhAlAGSSANFEFKAG.DTpNuTATFNNDIpLG+hVNL+VDAHTANFpG.I.hG.......NG...............GhN..TLDFSGVTsKVNINKLhTAuTNVslKNFsIpELlVpTps.ShGpYThFuEsIGspSRIssVpLpTGhpshaSGGVpFKuGcKLVIDEhYauPWNYFDARNlpsVEIs++hh.usPtN.hGpotLMFNNLTLspNAsMDYup..sLTIQGcFhNNQGThNhhVpsG+VATLNsGptAuMhFNN.lDSsTGFYKPLIKINsAQsLhKNpEHVLlKA+.IsYs.Vus.Gss....uhSNsNLpEQFKERLALYNNNNRMDTCVVR..NhsDIKACGMAIGNQSMVNNP-NYKYL.GKAWKNhGIsKTANsopIuV..LG.NSTPTpssssTTNLPTNTTNNARFASYALIKNAPFAHSATPNLVAINQHDFGTIESVFELANRSpDIDTLYANSGAQGRDLLQTLLIDSHDAGYARTMIDATSANEITpQLNsATTTLNNIASLEHKTSuLQTLSLSNAMILNSRLVNLSR+HTNpIDSFAKRLQALKDQRFA	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	1	2	2
+4918	PF03077	VacA2	VACA; 	Putative vacuolating cytotoxin	Griffiths-Jones SR	anon	Pfam-B_2866 (release 6.4)	Family	This family contains a number of Helicobacter outer membrane proteins with multiple copies of this small conserved region.	19.50	19.50	20.00	35.50	17.70	18.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.89	0.72	-4.38	10	460	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	51	\N	19	481	0	59.90	41	7.82	CHANGED	uhlGYIsGsFcAppI.YITGsltSGNuhuo..GGGAsLsFsuusslslssAslssppsssppS	....hlGYIsGsFpAppI.YITGsltSGNuhso..GGGAslsFsussslslssAshssppsss..S...	1	11	16	19
+4919	PF04333	VacJ		VacJ like lipoprotein	Kerrison ND	anon	COG2853	Family	VacJ is required for the intercellular spreading of Shigella flexneri. It is attached to the outer membrane by a lipid anchor [1].	25.00	25.00	34.90	34.60	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.37	0.71	-4.86	10	1871	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	1652	0	385	1266	1805	200.70	39	75.89	CHANGED	sstsppDPLEuFNRshasFN.sslDpall+PlApGYpphVPcsV+sGlsNFhsNLsEPsohlNpLLQGcscpAhpshsRFhlNTThGlGGLlDlAotsG..Lpppscc.FGpTLG+YGVusGPYlhLPlhGPsTlRDssGsllDth..hPhhhhlss......shuhs+hulpsl-sRAphLss..-sLlcsS.DPYlhhRsAYhQp+pa+lp	......s...thsDPhEuaNRsM.asFN.ssLD...Yll+PVAh.uYp..shsPpPsRsG..........lsNFhsNL.p-PsshlNslLQGcstpuhtchsRFhlNT.hhGhGGlhDVA....uh.s.s......Lp+....pcpc..FGpTLGaaGV....ut....GPYlhLPhhGPtTlRDss...GphsDs...h.......P...h...h......h...hsh...................sh.u.h..u...t.....h...s...l.....ps.......l-...sRA.....pL.L.ss......Ds.L.h.c.s..u.s.DPYhhl..R-AYhQ++ch.h.t..................................................................	0	94	207	299
+4920	PF04294	VanW		VanW like protein	Kerrison ND, Finn RD	anon	COG2720	Family	Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin  resistance gene clusters vanB [1] and vanG [2].  The function of VanW is  unknown.	21.70	21.70	22.20	23.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.95	104	1141	2009-01-15 18:05:59	2003-04-07 12:59:11	8	16	702	0	306	1013	69	131.50	36	30.04	CHANGED	tsRspNlplAuptlsGsllhPGE........sFSFNphlG.potpp.GYppu.l...l.hsu.....chss....ul.GGGlCQlSoTLasAshhAsLpllERpsHSh.lsYs......Ph....G.....pDATlsas....h.lDh+F+NsostslhIcs....ths.ssp...lssplau	......................................s.sRspNlpluApplsGslltPGE........sFSFNphlG..p.o.tpp.GYp..puhl...l.h.sG.......chsp............uh.GGGlCQ.....lSoTLYsAs..ht.A....s..L...pl..lERpsHShslsYs..........Ph..........G.....pDATlshs.....h..lDl+F+Nssstslhlps......hhs..ssp..lsspla...............	0	143	249	290
+4921	PF02557	VanY		D-alanyl-D-alanine carboxypeptidase	Bashton M, Bateman A	anon	COGs	Family	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.72	0.71	-4.31	63	2350	2012-10-02 01:02:30	2003-04-07 12:59:11	12	58	1623	4	473	2508	550	132.00	31	49.45	CHANGED	shhlcpcsupuhpph.hpAApcc..Gl....pLh...........h.hSGaRShppQptla..pt.sp..................tpstptstphsA.PGtSEHptGhAlDlussp........h........ptshtpsttscW..............................LpcsAtca.GFhlp..............a.Ppsppp.pGlsYEP...W.......HhRY.lGh	........................................................t...lptpstpshpph...hpA.A....pp...p.....Gh.....plt...............h..sSGa......RSac.pQpp..la.....pthhp................................................ppuppt.stp....h...uA.hP..G.....t.....S.....E..........Hp.....s.....GLAhDlss...s.s..............................................pttht.p.sttspW.......................................................................L..t...c.pA......t...c...a...G.FllR.........................Y..psc...p..p...T.GhtaEP.......WHhRYlG.................................................................................................................	0	157	322	407
+4922	PF04892	VanZ		VanZ like family 	Finn RD	anon	Pfam-B_5529 (release 7.6)	Family	This family contains several examples of the VanZ protein, but also contains examples of phosphotransbutyrylases [1].	24.50	24.50	24.50	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.73	0.71	-4.21	19	3861	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	2101	0	830	2978	740	136.10	18	66.89	CHANGED	halhallhlhhhhhFt..h...hh............tshshsLhPhtt...........................shhphhhsllhahPhGhllshhhtphp.....shhpslshuh...hhu...LhhEshQhhhsht.......ssDIsDllhNTlGuhlG.hh....lhhhht+hh.+t	.............................................................................................................................hh.h.......................................................hp..h......h.......................................................................hh.h.p..h.hhN..lh....ha....h...P...L.....G..h.....h.....h..h...h....h.h...t..p.ht....................................shh.t..s..l....h...h..u....h......hhu........l.....h...h.EhhQ.h.h.......h.s.ht.............ss-lsDl..hh.N....ol....Guh..l..G.hh.......lhh.hh.......t...........................	0	303	585	720
+4924	PF03490	Varsurf_PPLC		Variant-surface-glycoprotein phospholipase C	Griffiths-Jones SR	anon	PRODOM	Family	\N	20.70	20.70	20.70	21.50	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.66	0.72	-4.29	2	23	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	14	0	5	24	0	46.70	48	14.12	CHANGED	FssstWpPQSWMpDhRS.ItchsIsQVhhVGuHsAuoaGlph.SPFGhDAP	.......thtWpPQSWMcDLRS.It-huIsQlslsGoHNuuoYGIpptSPhuhDA......	0	3	4	5
+4925	PF01992	vATP-synt_AC39		ATP synthase (C/AC39) subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the AC39 subunit from vacuolar ATP synthase Swiss:P32366 [1], and the C subunit from archaebacterial ATP synthase [2].  The family also includes subunit C from the Sodium transporting ATP synthase from Enterococcus hirae Swiss:P43456 [3].	22.20	22.20	22.20	22.60	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.84	0.70	-5.32	10	1321	2009-01-15 18:05:59	2003-04-07 12:59:11	11	7	1055	5	489	1086	162	301.60	22	94.11	CHANGED	YlsARlRuh+u+LLs-pcascLlcscohEph+hhLEs.s-Yushlsslssh..ssptlE+ALppsLAcpachlhclusupl+phlchhLc+aDlcNIpsLI+uKhsstssEEllshhhPhG...sacphptls-usolEEll.ssLcGT.YtcsLpchLu..-h-.pshtlh.ptLhKtYat-hLchsh.....hpuc-pclhcEalchElDh+NlpshLRuKu.sGLosD-lp..lhlpGGpLtc.tLctLtpu-sh-tllutLEGTpYupslp-stpphtts............lpslEcsLcchllchhschuhhpPloVuslluYllpKEpEl+NL+sIA+sttpslcsEcIcc.ll	..........................................................................................................hpshlRshcstl.Lspppapplh.ps...c.s.h.-...............s.h.t.h.hL.ps....osYtt.h.l..sp......t......t...p.th-ttlpppLh.pp.a.phhhp....u..s.t.....tphlp.hhthpa..hcNlt....lllp....up.h....p..t..p....s..h.p..c.......l.h.........h...............s.........h..G...........h.....p.....p.....h.....t....t...l....h....h....s...p.s.....p....-lh...thl..h...........t..s.....h.....tt......hhp...phh........s..........p.............h....-.............p.......h.......s.l.p.h.l.h.s.h.l.h.c.........t..a.h.t..p..h.h.chsp...........t.s.tp..t-...lhpphl.t..hph...Dh.......pslhhhlpu.....ht....p.....ph....s...t.....s...t......ht..plh.sp.tG.p..l..s.c...t.h.h.tls.p..s.p..s..h-.phhsh...l...p...h..s....h.p..hl.hp.s.h.tt..t.................................pslE...c.h.hhpt..h.p..h.t.p.....uhh.tth...s.h...t..s..hh.ualhh+E.El+NlphIhpshtp.p.ht..ppIpphh.h.....................................................................................................................................................	0	184	295	405
+4926	PF01991	vATP-synt_E		ATP synthase (E/31 kDa) subunit	Enright A, Ouzounis C, Bateman A	anon	Enright A	Family	This family includes the vacuolar ATP synthase E subunit [1], as well as the archaebacterial ATP synthase E subunit [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.23	0.71	-5.04	17	1053	2012-10-02 21:03:42	2003-04-07 12:59:11	13	6	818	14	504	1038	112	184.00	22	89.44	CHANGED	hIppEAc-KAp-IpscA--Ehsh.Kschhcppctplcphhc+tcKQs-hp+phthSshh.puRh+lLps+--llpslhcpscccLtplsc-p..tYpphLcsLlhpulhcLt.EsplllpsRccDhpLlcsh.lsphtpchctpht.ps..hhs-s........................c.shGGVlltstcG+IclsNTl-uRL-hhhpphlspIpctLF	...................................................................I.p-ApccAp.cI.t...cAccEhph..htc.hh....pp..t....p..t...p..h...pp...h...hc...+..tc.+.p.s...........c..h..pp..p....h....p....h....Ssh.t........p.s....Rh.....c...lLp.s..+.p-lls........clhp.c....u...........pcc.L.t.p.l..........s......p.........s..........p.....................t...........Y.p.phLpsL..lh..pu....h....h....p.......lt.....c...s..p.h......h......l.h..s.pp...pDhp...l...l.c.ph..h..th..tt......htt......th......t............t.................h.....h.....s-p......................................p.ht.G..GlhlhstsupIplssTh-shlchhh.pphhspltthLF..............................................................................	0	194	321	422
+4927	PF01505	Vault		Major Vault Protein repeat	Bateman A	anon	Bateman A	Repeat	The vault is a ubiquitous and highly conserved ribonucleoprotein particle of approximately 13 mDa of unknown function [1]. This family corresponds to a repeat found in the amino terminal half of the major vault protein.	20.00	8.30	22.70	8.50	19.30	8.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-7.95	0.72	-3.90	85	662	2009-01-15 18:05:59	2003-04-07 12:59:11	13	12	77	227	332	619	5	43.50	31	23.60	CHANGED	hhVLspspALtlcAhpsa....pD.tp.....s....................RhsG-cWllpu..P..tsYlPs	....................hllspspALpL+Alpsa.........pD..tp.......uhp..............................Rh..sG-cWLlpu...s......tsYlP.....................	1	173	214	257
+4928	PF01847	VHL		von Hippel-Lindau disease tumour suppressor protein	Bateman A	anon	Swiss-Prot	Domain	VHL forms a ternary complex with the elonginB  Swiss:O44226 and elonginC Swiss:O13292 proteins. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor Swiss:P15692 mRNA.	20.00	20.00	20.10	20.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.67	2	136	2009-01-15 18:05:59	2003-04-07 12:59:11	11	5	97	14	79	139	2	121.10	33	56.67	CHANGED	RPRPVLRSVNSREPSQVIFCNRSPRVVLPlWLNFDGEPQPYPhLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDaPsVpKDlpRLoQE+ltpQ+ht-	..........................pS.tst..s.Vh.FsNp.osRsV..shWlsapGc..p.Y.ss..LtPGpth...clpTYhsH.WlFR..Ds.h..Tt..-..th.hV.pp..pc.............lahP.........................t.............t.....t............................s...............IphP..hh....oL+c....s.h..h.l.t...hh.t.....t..............................................................................................................	0	25	39	61
+4929	PF02209	VHP		Villin headpiece domain	SMART	anon	Alignment kindly provided by SMART	Domain	\N	21.70	21.70	23.60	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.70	0.72	-4.26	15	900	2009-01-15 18:05:59	2003-04-07 12:59:11	14	43	134	38	458	817	14	35.90	47	4.18	CHANGED	YLo---FpplFuMo+pEFhcLPtWKpppLKKchtLF	...aLSsE.-F.......p........plF.GMohpEFspLPhWKpspLKKcttLF...	0	137	202	310
+4930	PF04702	Vicilin_N		Vicilin N terminal region	Kerrison ND	anon	DOMO:DM04811;	Family	This region is found in plant seed storage proteins, N-terminal to the Cupin domain (Pfam:PF00190). In Macadamia integrifolia (Swiss:Q9SPL4), this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif.  These peptides exhibit antimicrobial activity in vitro [1].	26.70	26.70	28.60	28.60	26.60	25.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.99	0.71	-12.08	0.71	-4.59	4	32	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	13	0	1	40	0	123.70	35	28.90	CHANGED	sGR+s.-DDPppcYEpCpRRCc.-spGp+EQppCEcRCcpphcEcpppp....EDPQppYppCppcCpppE...R.h.pCpQpC.cpaEpp.ppp..............................pRQap-CQpRCppQEQtPccpQQC.RcCREQYpE.p.+Gcc-ph.....ctccpcoEEG	.......................thppC.p.Cp..tpt..pQppCpppCcppht.Ecpppp....................c......DPpppYcpCppcCpppc....c.p.p.CpppCpcpaEpc.ppp......................sp+pac-CQp+CppQEQtscpppQC.pcCccpYpEp.h+t.tc..pp.....tpctct-E.t.................................	0	0	0	1
+4931	PF00559	Vif		Retroviral Vif (Viral infectivity) protein	Bateman A	anon	Swiss-Prot	Family	Human immunodeficiency virus type 1 (HIV-1) Vif is required for  productive infection of T lymphocytes and macrophages. Virions  produced in the absence of Vif have abnormal core morphology and  those produced in primary T cells carry immature core proteins  and low levels of mature capsid.	25.00	25.00	28.30	28.30	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.46	0.71	-4.41	10	6238	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	93	4	0	6291	0	184.00	79	99.34	CHANGED	pEKcWlVhlTW+VPc.RIc+W+SLVKYhhYhoKcLptWpY.hHHapssas.a.TsSRllIPL.uc.uc.LcVssYWpL.TPE+GWLSoYAVuIpW...hpcpYhT-VDPssADpLIHspYFsCFo-sAIR+AIRGc+llshCpFPcGHK.QVs...SLQYLALhAl...lpp+pp+scssss+phsccptsshphA+pc.tpspppsGp	............MENRWQVMIVWQV.DRMRIRTWpSLVK.HHMYl.S.KK.AKs...WhY.RHHYESpHP.+lSSEVHIPL..G.........D....A.....+........LVIpTYWGLHT...G.....E......RDWHL.G...Q.GVSIE.W............Rp+...RYSTQ.VDPsLADQLIHLaYFDCFS.-SA....IRpA.ILG+l..V..pP..RC.E.YQAGHN........K.VG......SLQYLALsAL..................ls.P..K.K..h.....K..P...PLPSV.p..K.L.TEDR.W..NKP.QKTKGHRGSHTMNGH....................................................	0	0	0	0
+4932	PF01044	Vinculin		Vinculin family	Bateman A	anon	Pfam-B_1420 (release 3.0)	Family	\N	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	968	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.98	0.70	-13.84	0.70	-6.55	10	1199	2009-01-15 18:05:59	2003-04-07 12:59:11	14	14	103	65	681	1153	3	334.80	14	87.69	CHANGED	.h+T+TlEplLEPlspQVopLV.h+p...uphctstshcLossVAuVppAssNhlchGc-hspposD..Lcc-MssAlpcVcssuchhcpAupphpcDPhSostRsphlcuARulLSusocLLlhhDpu-V+KIlcss+tVpDhLssscsspoh-DLsshhKsluPshs+lschlscRQQELs+.pHR-.LlsuhsslKchuPlLloAhKsalcp....P..slpEAtcNRsalsccMs-tlNpI.cVLQhTo...........oshp+shuuhuscLssAL-hLccs..........hI...lDsushsptRstPp.ccclcullSssutMADu.CshcsRtp......ths..........................................................................................................AEss.............t.................................................................................................................................................sscQALpsLloEhtpsAspps......chssLsssID+.........hptcsc................DL+cplR+AlsD+VSDsFhDToTPLhlLlEAA+u.....G+EcshcE+ApsFp-HAs+LspsApLusuhu..sNccsVchlptoAsQl-sLsPQVIsAA+ILhppPsSKsApEph-shKpQWtDpV+hLTstVD-hTsscDFLssSEsHIhcDls+ChhAlps.........t-scsLsssAuuIttRusRVlhVscsEhDN.EsshaTE+VppAschLcsslsPhhs-ttplAsNstcss....sspsac-s..chlsAsRhVtDAlp..........................................................sIpculLM..pcsPs-lsssophc.....pED..sssRssssscsss......csssssEoscE..tplh.EcKsplstQhpshhtstppLcpElsKWsspGNDIIuhAK+MshlMhEMo-hsRGcG..tTppDlIssAKcIA-Auscls+LA+plAcQCsDpph+psLLthhpRIshhspQLpIhSpVKAshhshus.........Elsspsh-.usppLlpsApNLMpSVhpTV+AA.sAShKhRoc.......uusplpWhhKsPhpp	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	189	244	434
+4933	PF02236	Viral_DNA_bi	Vir_DNA_binding; 	Viral DNA-binding protein, all alpha domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_1651 (release 5.2)	Domain	This family represents a domain of the viral DNA- binding protein, a multi functional protein involved in DNA  replication and transcription control.	23.50	23.50	23.70	38.00	21.60	23.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.80	0.72	-3.82	10	131	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	98	7	0	139	0	87.80	45	18.36	CHANGED	PlVSAWp+uMElhstLhE+Y+VDsc...sh+hLP-pu..psa+KlspsaLNEc+hsl.LTFSSpKTFsslMGRFLtualpsaAGltsspas	.........PlVSuWEKGM-sMssLME+Y+VDss.+sua+LMP-Qs..ElapKlC.poWlNEE+RGlpLTFoopKoFoshMGRFLpualhuauGIuppsWE.......	0	0	0	0
+4934	PF03728	Viral_DNA_Zn_bi	Vir_DNA_Zn_bind; 	Viral DNA-binding protein, zinc binding domain	Bateman A, Mian N, Griffiths-Jones SR	anon	Pfam-B_1651 (release 5.2)	Domain	This family represents the zinc binding domain of the viral DNA- binding protein, a multi functional protein involved in DNA  replication and transcription control.  Two copies of this domain  are found at the C-terminus of many members of the family.	25.00	25.00	64.00	39.20	21.80	17.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.66	0.71	-4.03	22	260	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	98	14	0	276	0	122.10	35	50.61	CHANGED	stCpshh+tsst...G.c.hChhsshhlspspsl-hssso.-suhtAhhc.P.shsh.ssN.htRssht.......hpNsDh+lss.Dlhp...shphspp.hu.sas-s.....hhsphtapp.thpappshhPpsp	.....tCss.p+s....ss.s......G..+.hChhsshhlspscsl-hDssS.-..s.u.hA..hcpP..hsh.spN.hhRNsht..................hsNsDh+hss.Dhhs...s.QhSp+.hu.hFsEs.........shsphtapp.hhtahpsshPsh............	0	0	0	0
+4935	PF00426	VP4_haemagglut	VP4;	Outer Capsid protein VP4 (Hemagglutinin)	Finn RD	anon	Pfam-B_161 (release 1.0)	Family	\N	19.80	19.80	19.80	20.70	19.40	19.60	hmmbuild  -o /dev/null HMM SEED	776	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.36	0.70	-6.57	9	3505	2009-01-15 18:05:59	2003-04-07 12:59:11	13	2	491	35	0	2781	0	337.90	67	99.90	CHANGED	MASLIYRQLLsNSYoV-LSDEIpsIGopKopNVTVNPGPFAQTsYAPVsWGsGElsDSTsVpPsLDGPY.....QPoohp.PssYWhLlsPsssGVVhEu...TssoshWhAslLlEPNVppssRpYslhGpshQlsVsNsSpo+WKFh-hhKsossusasphsoLhos.+LtuhhKps.splasYpG-oPsuspshhssss.hsslshshps-FYIIPcSQputCsEYIpNGLPPIQNTRNlVPluluSRsIh..RAQsNEDIVISKTSLWKEhQYNRDIlIRFKFuNoIIKuGGLGYKWSEISFKssNYQYoYpRDGEpVsAHTTCSVNGVN-FuYNGGSLPTDFsISRYEVIKENSYVYlDYWDDSQAFRNMVYVRSLAAN.LNsVhCoGGsYsFtLPVGsWPVMpGGAVoLphAGVTLSTQFTDFVSLNSLRFRF+LoVpEPsFoIoRTRsopLY..GLPAuNPNsspEYYEhAGRFSLISLVPSNDDYQTPIhNSVTVRQDLERQLs-LREEFNsLSQEIAhSQLIDLALLPLDMFSMFSGIKSTl-AsKSMATsVMKKFKpSpLAsSlSpLTcuLSDAASSlSRuoSlRSs.SssSsWTslSpplosssssspslSTQsSsIS++LRLKEhsTQT-G.MsFDDISAAVLKTKIDKSsplstssLP-IITEuSEKFIPsRuYRlIccDpVaEsos-G+aFAYKV-TFEElPFDl-KFA-LVTDSPVISAIIDFKTLKNLNDNYGITRcQAhNLLRSDP+VLRsFINQNNPII+NRIEQLIhQCRL	................................................................................................................................................................................psYsVsL.DEIppIGSEK...o.QNV.TlNPGPFAQTpYAPVNWGHGEINDSTTVEPlLDGPY.....QPTTFsPPsDYWILIsS...NTsG...VV.YES...TNNSDFWTAVIAVE....PHVssssRQYslF..GENKQFNVc....NsS.sKWKFlEMF+u....SuQs-FhsR...RTL.TSDT+LsGlLKYG.GRlWTFHGETP+AT..TD.u..Ss.TuN...LssloIsIHo..........EFYIIPRSQES..KCsEYINNGLPPI..Q....NTRNVVPlSLSSR.SIpYp.....RAQ.....VN.E.DIsI..SKTSLWKEMQYNRDIhI+h............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+4936	PF03225	Viral_Hsp90	Vir_Hsp90; 	Viral heat shock protein Hsp90 homologue 	Mifsud W	anon	Pfam-B_2880 (release 6.5)	Family	\N	25.00	25.00	56.60	56.60	22.90	20.10	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.68	0.70	-6.21	17	124	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	41	0	0	124	0	433.40	32	96.48	CHANGED	ssphhtchhphhatcs-hccphpchhshlhpp.tp.sp..ats..t...h.sasushhlpssplhsssssshEhhclhllahhhlp.shhc+osasscshh.sslshtpshtphc..ahshsl.......cshGCpaohpDlpp.....phss.st..hth.plaplsNShG+Llshp-lpstshhsF.plssspsssslssshssNchhhpClplacp...hssspusts+hphppchhcshlshLtspp..hpphscNP.LlhuhhhshhpphsspssuFccNhcslc.lpssahshlcclFthshphs..-scLhhs..lspspls.......pllsp.hhluphlc..pshhs.sss.ssLscclDthlsc.hl.p.ht...t.spshlhsuhLal.....aGpapTNtpRh.ppPpphphshpt......pshphphSslps..lhsplppphPch.......NlhRtWsstRuscAhtlF+shs..FpPhhasplPslhsYMpFDFaKtlshptloc-EhpshpsL+h.s...............................cs+oststpsppchcshlh	........................................................t.p..h.phhphhhtct.hpphhpp.hp.h.tp...................phtssh.hpttph..ss.ss.p..phhllh...h...th.phsshs.tshh..thp...p........hhshs........pp.GphashsD..Vcshhh....s.sss-h..sts-psasLSNSsG+LlsssElcshc...shsF....spshcs.sssssssphpsaLshCls...Lacc.....pshpssshhslhh.hasslhpsLsohs.hhcphscNP.LlsGhll-hhhc.pVahsoFcsNl-sl+hh.puphhsllhslashspspc...D-+lLhs...hsss-hsht..shlslhDshlllGs.lRpl-hhsp.ssshssLsp+lDhhlss.............sssc..Lpsshhas......a.uhapss.pRh.ppst.hph..t.......t.h.hphsslpt..hhs.lpp...ph.......shhRtahut+uphAhpla+phs..F.Ph...plPshhsah.hDFaKtls.shlotcEh.tLpplc..s...............................c..................th..........................................	0	0	0	0
+4937	PF04530	Viral_Beta_CD		Viral Beta C/D like family	Waterfield DI, Finn RD	anon	Pfam-B_4973 (release 7.5)	Family	Family of ssRNA positive-strand viral proteins.  Conserved region found in the Beta C and Beta D transcripts.	23.40	23.20	23.70	54.40	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.85	0.71	-3.95	12	26	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	16	0	0	26	0	117.70	38	71.27	CHANGED	h.Hs.sCsCspC..sspsp.hsus.p........pssss.sEpsspt.sh.sshhsppYhhllsslhll..h.hhlYlh....sssssssssYaYQDLNSVclchG..sPlDP-VItAIHHaQcaPFGpsPth	IhHS.sCsCscCphssssohsssspp.........sssosVEpTsct.hh.hsshsspYllhlsslsll....hslYhh....sss.ssshshFaQDLNuVpIchuh.sPlDPcVItAlHHWQ+hPFGcsPt...	0	0	0	0
+4938	PF00729	Viral_coat		Viral coat protein (S domain)	Bateman A, Griffiths-Jones SR	anon	Pfam-B_870 (release 2.1)	Domain	\N	23.00	23.00	24.00	24.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.15	0.71	-5.01	13	577	2012-10-04 01:49:40	2003-04-07 12:59:11	13	2	91	43	0	572	4	198.00	26	66.94	CHANGED	psGuIhA..PVAhuph.lpsppP+hp.pspG....SsploHpEllsslssoou..hphsss.ss.t.phplNPhNsulFsWLsslAsNa-pYpFsSlplpYlPhCsoTosGRVAhhFDcDupDs.PssRspLushsthspoAPWs................tssLslPsD.......stcRFssDouosDtKLlDlGQ..........lllATYG..uuussslGDlFlpYoVphhpPpsos	.....................................................t.....hA..PVA.upp.ls..shsPt.h...poss........sh.sl.ppsEhlss.lpp.....oss......hshp.........saslsPhNs....t..hspl.slApsYsha+hTphclhYlPps....u......s.sss......Gp.lthsa.hD...huDsh.Pssps...p...h...uphushlsousWt.....................tssls..h..s.hD...........t..h.a.t..s......s......p.lh.s.st..............hhh.s.u........ts......hGplhhphtl.h.......s.................................................................................	0	0	0	0
+4939	PF00747	Viral_DNA_bp	viral_DNA_bp; 	ssDNA binding protein	Bateman A	anon	Pfam-B_490 (release 2.1)	Family	This protein is found in herpesviruses and is needed for replication.	25.00	25.00	40.90	40.80	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	1122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.80	0.70	-13.80	0.70	-7.34	11	204	2009-01-15 18:05:59	2003-04-07 12:59:11	12	2	108	2	0	187	0	910.50	32	95.55	CHANGED	Mpsc.....csssh..uPluPsuYlYhhtpsschh-hluhLShpsssSslslsPLLhsLTVEssFss....sV+o.hsshsG.ullhKlTo..FpPssahFHssctlss.sps..sLs+LC-cARp+FGhpuaps...ss+spTshtsLCsslGhsPspslhalVVspGFKEhlasGpLlsphttsspVplsss-ul+IPLYPhpLF...spphhs-..st.thshsctFl..psFYsssLSchLFhhVaTuhu.ALRhpsscsllcAuh+QhlpDsppssKLsPcKsapuasupphsu...........h-ps.........chMLsDshssELAhSasulah-ulY-.ssshsas-WPllpsu-spts+lsALssaph+LusHVuAhlFSsNSlLYhoclshhssscppssos....p.ohh+hhphssuhsusscps.pDu+tl.chsG.....ssupspcaospHLAhhCGhuPpLLu+hlaYLpRssshsssspups-lhpalss..soushCshCsGcsspoChpTshhRl+sRhPthspss++-PsVhsshSphYuDsDlLGNauph.sl-pc-s.scsu+ss............................................th..sol-RhhhhtphhcYscKt...phlssssGc..shslps+psFlsllsslppslDspVspFhpslhcsps...R-tltsuspuhslshsPaAsuFsPlhsahaaRolLuVlQsLAL.pspuahsDpPlpGpphscWhhppFQolhssFhsshhc+GFLss+slKlspssstsphhshpshtp.Gphstpsh-s+luRlSltsl+slRVKNRslapuups..shupsah++s.........sc++ps.lpGsLuFLLhpaHcpLFPss+hs......sL.FWpplppNphP.ssslhshE-hsshlpFlhphos-Ys-hsllDlsPsslhsaschhhpNplLphhGapsYhhohhshhsthopps.s..aPslLhpps..phuSstEash+spthpssuhssshTushoppshl+slhspRslVoluloIpKYsGhsGNcclFQhGplGahsGuGV-RNLsPss.u.....tshpFMR.p+allAT.hsshll++.sptssssa-s-ll+ptlhhIl..-utshssss.lhslscslusRsp..p.shDDhLahlDs.EhLAcSlhcphsplh-pGst-aSl-shpcVhcsstp..sth....suutsa-Fuuh	............................p.s....sssGPhualYhh.htt..hc.luhLuhpstss.ssslhPLlhGLTVEtsF.h....ssts.hpshsu.ul.hKlos...ats.shhFHssptl..s.sps...slpchCctARpcFGhpsats....s.th.TshttlCttlshpspphhhalVlspuhKEhlahsphh...phtthtpVpls.ttpsh+lPlYs.pL.F................th..p..t.......hshtpth...hsFas.slschLa.hlhsshu.uLRhppspslhcuuhc.hhc-stpsshLssphpahshtspt.ps.............s....................phhlssshss-hAhuhtshh.tusa..-...t...shppWPlhpstps.t............shhpALsta.h+hush.luAhlFSsNSsLY.ocls.hssss.tstu....................t.shh+.h.h.sshhs.hs.ps.p-u+hh...thps...............hshtspcas.pHLAhhCuhsPtLluphhaYLpRsshhths..hptp..shhpalss....s..ss..CphCttpsptsChpTshhRlctRhP.hstt.+tt.hVhsshsp.asDsDhLGsauth.hhcpt-s....sscs..................................................sh-Rhhh.....phhcp......h.s..ss.......u.p....p..lp.....sttsFhthhsslpphl-pps.phhpslhctpp....R-tlttuspshslshsPYu.u.sPlhthhhhRohhsllQslAL.pstshhhspshpsp.hp....tpFQslhtthhhs..ptGFlss+phpsshsp.hshhhs..hhtp.s.........t.shhshpsclsRlol.s.+phRlKNRslapuups........shs.pshht+s...........sppchs.lpGsluFLLhpaHptLF.Psst..s......s..FWptl.pNphP...sthhshc-hps.ltalhpho.pYtthshlslsPsslhphsp.hhtNthLphhsa......p....pahhshhshhhthspps.s...s.hhhh.t....huu..sh-h..h.hphhh.phs.t.h.t.hsshhsppphlpslhptRshVslslulpKYtGhsG.s.pclFQhGphu.h..Gs...+slss.............htF..R.p+allAs.hss.hlhtt.st.h..tss.h.a-sslhcphhhhh...cuss.hshss.hhshhchlu.sRs.p......ph-Dhhhhl-s.phlupphhchhtpl.pps.s.taSh-shhphhct.tt..........st.h.s....h...............	0	0	0	0
+4940	PF01443	Viral_helicase1		Viral (Superfamily 1) RNA helicase	Bateman A, Ahola T	anon	Prodom_1256 (release 99.1)	Family	Helicase activity for this family has been demonstrated [1] and NTPase activity [2]. This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis [3].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.76	0.70	-4.84	72	2712	2012-10-05 12:31:08	2003-04-07 12:59:11	13	100	786	0	67	6146	639	226.40	20	13.31	CHANGED	hllcGVsGsGKSohlpphlpp...........hpsssthhstth......spssphpspplcsh.hshht.....schlllDEahhh..t.l.h..h...spsphsllhGDshQhshpsp.....hsph.sph....sphhshphshhhsshshthtspp..........h.pststpssth.....thsspsh......slthtshspphhpshthp..............shssp-spGhpacsVollhpppss...........spphhhVALTRpppslhhhs	......................................................................................................................................................................................................h....GssGsGKo....p.......l...h...phht................................h...s.h...h.phh.......................................p.hp..s...h.t...h......p....s..........h...h............s.....h...ht.........................schl.hlDEsh...h...h...p....s...h......h...h....l....h......t........h......h.....p..s.....p..........p......l.h..h.h..G.Dsp.Q...h.......s..hh.....s....h........t...t.....h....h..h....t...h.h..s.ph...........................s...h.....t...h.......p....h.s..h....R.s...st..pl.st..hlpsh....................................................t..sppps.h................thsspsh...................hth.hhs.h..p..t.....h..t.th.tp......................................................................shTspp.sQG.....h.....T.....a.c..t..V..............h.l......h...........t....s........p.....s....t...s..........................sppc.hhVALTRtppplhh................................................................................................................................................	0	19	50	61
+4941	PF04521	Viral_P18		ssRNA positive strand viral 18kD cysteine rich protein	Mifsud W	anon	Pfam-B_2612 (release 7.5)	Family	\N	23.10	23.10	23.20	105.30	22.60	23.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.90	0.71	-4.66	10	25	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	12	0	0	26	0	118.30	47	72.80	CHANGED	hsshcsspKhRtplYppLGL..ssVpC+LsussGhsCGMPAAls....h-cucsc.....Lsh.DGaCGEKHcshshShAhR.splpshphcL-pLEc+cEsL+sphpthstst+ssps.s.sstKhs+hKs	..+slhCVSKYRtSVYKsLGL..ssVKCRLPuDCGVNCGMPAAFV....LEcGHPc.....Loh.DGaCGEKH+GYVlSGAWRpAQLRoLNtELDpLE+RtEpLKsQI+sLotst+sssA.sYsPpKls+hK.A..	0	0	0	0
+4942	PF00998	RdRP_3	HCV_RdRP; Viral_RdRP; 	Viral RNA dependent RNA polymerase	Finn RD, Bateman A, Griffiths-Jones SR	anon	Pfam-B_315 (release 3.0)	Family	This family includes viral RNA dependent RNA polymerase enzymes from hepatitis C virus and various plant viruses.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.55	0.70	-6.00	33	17276	2012-10-02 12:54:00	2003-04-07 12:59:11	18	48	263	228	1	13782	0	190.90	62	44.48	CHANGED	hhshsushh...sppcphh.lst.hssshhhtsHNpshsNhpRulhERVahVp..tptp....lhs..........cPh.ssFcc.lpthtppltphlh...ptsslo.pchsp.YpGt+tphYp+AlpS.lshpslppc.DuhLcsFlKsEKhslssKsDssPR...lIpPRsPRYNVtlGpaLRhhE++hh+s......lspsatGsohhpGYospptuchlhptWppapsPsAlGhDsoRFDQHVShcALcaEHSlYpusatssp...pLtclLshQLhNpGsuhss-Gh.h+YphcGCRMSGDhNTShGNsllsshhspshh+ths..lcspLhNNGDDCVlIsEpsshcpspp...slpchatcaG.FsspsEcPsYclEplcF..CQspPlhsss.tashsRp.hsshuKDshuhsshpss..ssspsWlsulupsGhslsuGlPlhppFaphhhpsst......thstphhsspash.......shhthhuh.thshpstsssptsRhSaaL.uaGlsPppQhtlEsthsphplptp	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................V...T...E...p.DI.R..sE...E.....tIYQsCsLtPpA.....RpAIcSLTERLY...lG...GPhhNS......K.Gp...sC.GYRRCRASGVLTTShGNTL...T........CYl.KA..pAA.......C.......R.....A..............A....t......Lp......D.......sT.......M....L..V.......CGDD...LVVI.sESsGspEDtt....sh....................................................................................................................................................................................................................................................................t..............................................................................................	0	0	0	1
+4943	PF02407	Viral_Rep		Putative viral replication protein	Bashton M, Bateman A	anon	Pfam-B_1223 (release 5.2)	Family	This is a family of viral ORFs from various plant and animal ssDNA circoviruses.  Published evidence to  support the annotated function "viral replication  associated protein" has not be found.	25.80	25.80	26.10	25.90	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.04	0.72	-3.98	19	1309	2012-10-02 18:54:06	2003-04-07 12:59:11	11	2	283	2	9	1241	181	77.10	47	29.31	CHANGED	uppWsFTLNhsst.......hs.l.hs-clpYAlhtcEcu.p.GpcHLQGalphK++.ppLsplKplhsu.puHhEhsR.Gosc-scsYCpKE	..........................h..hW.sFTl...ot...................t....hl...h............s.hpY.hlhGcEtspp.tTPHLQGahph..ppK..p.p.....hs.plK.thhss....psHlEKAK.GoDppNccYCSKE.........................	0	8	8	9
+4944	PF05101	VirB3		Type IV secretory pathway, VirB3-like protein	Bateman A	anon	COG3702	Family	This family includes the Type IV secretory pathway VirB3 protein, that is found associated with bacterial inner and outer membranes [2]. The family also includes the conjugal transfer protein TrbD family that contains a nucleotide binding motif and may provide energy for the export of DNA or the export of other Trb proteins [3].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.85	0.72	-4.00	24	967	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	663	0	249	799	41	88.50	20	43.83	CHANGED	Muttt............sPla+uhsRPshl..hGsst-hlhhs.slhsslLhhsstshhsslhslslahhs....phhscsDsh.hptlah+.......phph+saa.....tsp	..................................ssla+uhTRPshl..hGls..hthhlhs....s.....hh...s.sh.....l......hl.....h....h...p......t......h.......h.......h.h.....l.l..s.h.s...l.ahht........hhss....ccDsh.Fhtlhhp.........p.p.t.ha...t.....................	0	42	134	187
+4945	PF04335	VirB8		VirB8 protein	Mifsud W	anon	Pfam-B_1984 (release 7.3)	Domain	VirB8 is a bacterial virulence protein with cytoplasmic, transmembrane, and periplasmic regions. It is thought that it is a primary constituent of a DNA transporter. The periplasmic region interacts with VirB9, VirB10, and itself [1]. This family also includes the conjugal transfer protein family TrbF, a family of proteins known to be involved in conjugal transfer.  The TrbF protein is thought to compose part of the pilus required for transfer [2]. This domain has a similar fold to the NTF2 protein.	20.40	20.40	20.50	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.36	0.70	-4.75	104	1418	2012-10-03 02:27:23	2003-04-07 12:59:11	8	5	855	7	317	1203	73	202.90	19	86.07	CHANGED	putph.p-chspsptpp+.phhhl.....uhsuhhluhhssh.ulsh..hssh..pp.h.P...allp.VDptsGtsphlssh....pph....pst.s-shhphhlspalp.sRps.hssssh.p..psappshhh..osssstpphpsah.....t.t...psPhshhupps.h...pVclpSl.shh....ss.....p......shp.Vcapcph..pptsssh....tsp.pasuhlshth...pssh.sppphhtNPLGhhVpsaphspE	..................................................................ph.tpphtthptpp+thhhh......uhhshh..lsh..hhsh.u...lsh....hhsh....pp.hhP...allp..lDp.t..Gp..sp.hls..h...pst........php..s.cshschhlspal....p.hRps.hs..sl..p.....pshpps.hhh..osspst.pphpshh..p.....pssh.pph..tppt.l........plplt.Sl...shh.......ss.............s..................shp..Vc...a..ppph...hptssp.............ttp.papuhlsa.h...p..s.h..sppph......h......hNPhGhhVssaphst......................................................................................................	2	56	177	240
+4947	PF00286	Flexi_CP	virus_P-coat; Virus_P-coat; 	Viral coat protein	Finn RD	anon	Prosite	Family	Family includes coat proteins from Potexviruses and carlaviruses.	22.90	22.90	23.40	23.10	22.20	22.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.69	0.71	-4.48	17	1308	2009-01-15 18:05:59	2003-04-07 12:59:11	15	4	134	2	0	1218	0	129.90	41	54.26	CHANGED	SNshAosE-lttItsshps.htlPssslstshhplshhCscsuSSshss.pGss.h.s.usshtsls.uhh+tpso.LRphCphYA.llWNhhLspNpPPAsWushGap.psKFAAFDFFDuVpssAAlpPspGlIRpPTptE	............................thAsstplttlhthhtt.hGlspppht.p.shhclshtCucsuSSthsshhGss........s.....sh.sp.s-l.s..ul.h.+..phs.T.LRpFCthYA......lVWNhhLtpspPPANWsttGFptssKFAAFDFFsuVsss.AAl....p..P.hpG...lhRtPTctE........	0	0	0	0
+4948	PF01347	Vitellogenin_N		Lipoprotein amino terminal region	Bateman A	anon	Pfam-B_1280 (release 3.0)	Family	This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100.  These proteins are all involved in lipid transport [1]. This family contains the LV1n chain from lipovitellin, that contains two structural domains.	21.00	21.00	21.10	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-12.79	0.70	-6.29	44	1005	2012-10-11 20:00:59	2003-04-07 12:59:11	17	42	272	1	433	992	1	434.80	17	32.52	CHANGED	apss+pYpYpacupshsuL.p.husthuGhtlpuclplpsp.........spsphhhplppsphsphpthhsp.......cshhsssp..........lphphhshhppPhchphssGh.lsclhsspsssshtlNlh+GIlshLQls.hpsspth.pht....................EsslpGtCcThYslpp.sp.....................phlplsKo+shspCpp+hthphGhs.h.sphp..sppppps..lpposssphhlpsp.s..shhIppupsppphhlsPh.htp.ptupspu+ppLsLhphpsps...hs.ssshpshssLlYphssph.....................................................................................................................................................................................t...hPhhhhphssttt............plscplpp.l.ptstphscpcs..+.FspLlpllRssstcplpplhpphtsp...................phhphahDAlspuGTtsAlphlpphlps..cclpshEAApllsshspss.tsspchhchhhpLspssplppp.hLppouhLuaushlpphpss.....................psss.pchlp.ltpphp..pAlsctcp.chhlhl+uLGNhGpspslpshp.hL.upt.......plsthlRlthlhuLcpl..scppP+hlpsllhplahspsppsE..lRhsAhhhLhcopPshshlpplAphspp-s..shQVsuhlhStlc	.........................................................................................................................p.Y.ath..ps.........t.h..........t....t...............s.shhhps.l.l.t.............................t.p...h.h.p..h......p..h...t.....h.....t...t.................................................................t...h......t..h....Phhh..th.............p..Gh...l.t.pl..hs..ts..s.h....h.Nlh+ulhshhQhs..hpt..tpt................................................Es..sh.G.Cps.Y.hp...........................................................................h.lh+..p.shppC...p.t.h......h....s.h.t...........................t....h....................h..h...p.t..t..................h.ps.s.p....h.h...............t.....h..h..s.p.pl.h....p...tt..........................sl...h.t.................................................................................................................................................................................................................................................................................................................................h.t....................th..hp...htp.................................tt........t.........h..hhp.hp.hp.pp.....l.thh....tph.............................................................................hhhpsls..hts..sh..hhhphh......tp.t....h...h..h...h...............s.s.....thhp...............h..........................................h......hhht.h.th.h...t.h..................................................................h.tth.h.......h..t...ht...........t...................ph.hhlhsl..t.Nh.....t...............t...h....h...hh.t................t.........ph.....hl.sht...........h.....p.hpthhh.lh.p...t.....c..hRhhA.h.hhhht..s.P.s...htth.h...h.....-...........ph.thh.s........................................................................................................................................	0	145	187	351
+4949	PF05090	VKG_Carbox		Vitamin K-dependent gamma-carboxylase	Moxon SJ	anon	Pfam-B_6307 (release 7.7)	Family	Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl  carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase [1].	20.40	20.40	20.60	20.40	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.66	0.70	-5.63	10	332	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	226	0	183	348	246	332.40	23	68.03	CHANGED	ulFRllFGlLMhl-lhpctuhGalDp+aL-Pphsh+F.hF-alpPLPhshMYhlallMhluAlsIMLGh+YRlSslhFhLsahYIaLLDKToaNNH.YLhuLLuFhLlalsANR...YaSlDuhh.NsslRss.cVPhWNYshL+sQlFIVYFaAGltKLssDWlpG...uh.s+HWLhssaclhl.s-Llsh.lVHas....GLlaDLhlsFLLhac+TRhhuhhhlshFHlMNSpLFsIGMFPYlMLAsoslFFsssW.........s+th...h.phLphlh..............h.t..phhpppsshsp...hh.......ccthhp.tppPhltp+lushFslhahh.QLhLPapHFlhpGps.WTpthYtaSWcMMl+o+ss.asphplcDspTGcpsalsPpsF...pQp+phpspsDhlhQYAppLupphsppshs.....plpIYhDlaVSlNGRhpQRlhDPclDlhpscWssFppssWlLP	.......................................................................................................................hRh.huhhh..h.....h.............................h...........s.....h.......h........t......s................h..pa..h....h.p.h..h...s.h....s......h.hh..hl.ahl..h.h.l...hu.h.hhhlGh.hh......R.h.u.h....h.h....h....h.........l.....a.h.h.l...hh.st.s...s.a....s...+......h...l.......h.tl.l.hhhh...h..h..hsss..p......hhSlD.....sh.....h....p.......p...........h.......t..........p.........t.......p........l........s...........h........W.................shhl.lp........hQlhllYhh..AGltK.l.p...s...-...WlpG...........shh..p.ha........hhs...h...p..h......l...........s...p........l..h.......s........h......h.lt...h........h......h..u...ll..h-L..s.h.sh.hL..h....h..c.t.....o......R...h..uhh..hshhFH.h.h.su.h..l...h..s..IG..h..Fs.a..hhl.us.s..l.F..h.s.sph...........p............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	77	128	162
+4950	PF04649	VlpA_repeat		Mycoplasma hyorhinis VlpA repeat 	Kerrison ND	anon	DOMO:DM04353;	Repeat	This repeat is found in the extracellular (C-terminal) region of the  variant surface antigen A (VlpA) of Mycoplasma hyorhinis. Mutations that change the number of repeats in the protein are involved in antigenic variation and immune evasion of this swine pathogen [1].	25.00	25.00	59.10	30.80	23.40	14.00	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.71	0.73	-5.60	0.73	-4.18	6	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	3	0	16	51	0	13.00	98	28.24	CHANGED	KTENTQQSEA.GT	KTENTQQSEAPGT	0	0	16	16
+4951	PF01660	Vmethyltransf		Viral methyltransferase	Bateman A	anon	Prosite	Family	This RNA methyltransferase domain [1] is found in a wide range of ssRNA viruses, including Hordei-, Tobra-, Tobamo-, Bromo-, Clostero- and Caliciviruses.  This methyltransferase is involved in mRNA capping.  Capping of mRNA enhances its stability. This usually occurs in the nucleus.  Therefore, many viruses that replicate in the cytoplasm encode their own [1].  This is a specific guanine-7-methyltransferase domain involved in viral mRNA cap0 synthesis. Specificity for guanine 7 position is shown by NMR in [3] and in vivo role in cap synthesis [4].  Based on secondary structure prediction, the basic fold is believed to be similar to the common AdoMet-dependent methyltransferase fold [5]. A curious feature of this methyltransferase domain is that it together with flanking sequences seems to have guanylyltransferase activity coupled to the methyltransferase activity [5]. The domain is found throughout the so-called Alphavirus superfamily, (including alphaviruses and several other groups). It forms the defining, unique feature of this superfamily [2].	20.70	20.70	20.70	21.10	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.28	0.70	-5.79	122	1584	2009-01-15 18:05:59	2003-04-07 12:59:11	12	52	396	1	1	1647	0	318.10	19	22.63	CHANGED	hsaslstpttphLpph.....GI.hsshus.sHsHsssKslEs.hhhphlhshl.sp....sssh..ltlKssKh.phlpptt.........hs...........hhN.hlss+DhtRY.....ss....................................................................p.......................tp..h.h........ttp....hsahtDsLaahshpplsshh.ppsphppLhuolVhP.sEhhh............................tpp..ShhPplYshphp.....................ps..................................................p.......hhahP-uptutuYppsh.sthpaLpsspl..h.tt..................shslphlpShsupHlhhIp+.spths.....................................................................sphtoFt...ctlhhs.....................................phhh.p.hs...p...........phslspshhpplhpYlcol+phshpss.....................................................hu+lpphhsc	................................hs..t.phl.ph.....tl.h.pspt.h....tsHshstshcp...h....hphh........tphs......tshh........l-lGus.hphhhpsp.....................Hs....ssshhss+DstRh.....hp.....phtth.t.ph.t......t...hp..t.....................................................................................hC.p.s................................................................................................................tsCp.hps............t......hshhhpslY.....hshcshsphhhpptht.hhhsshhhs.sphhh.............................tpt..shhs..p.h..s....htctp..................................................p.....hha....stusht..Yscshp.lhpahpsshh.....h..st...............................shhh-hlh.s..hsshh..hh...plst..ssthh.........................................................................p.hs.......ptl.....h..............................t.hl.thhp....t..............hh.ht.....hpph.phl.......uhpphhhhsu....................................h.........p...................................................................................................................	0	0	0	1
+4952	PF00695	vMSA		Major surface antigen from hepadnavirus	Bateman A	anon	Pfam-B_168 (release 2.1)	Family	\N	29.10	29.10	29.30	29.20	29.00	29.00	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.32	0.70	-5.25	4	23454	2009-01-15 18:05:59	2003-04-07 12:59:11	14	10	96	4	0	17711	0	209.40	74	95.40	CHANGED	hs.s.uKshsscch-Gs.lh.ph.Aup.lP....Gsh...GphsTh.H..lhs+s.psptlpTh.pshs.PtusupR.uhcpPTPhoPP.hshpPctspKsppuF+Qh.p-...tPpsssphsP..........s.hc.pss.sPllpstShl.oh.........sshltsPsLspc....sohuGlLusLlGL.VuFFLLTKILpIhppLDWWWhSLS.PtGp..CshQNotuQTSsHhssSCP.sCPGFhWhYLRhFIIFLLlLLlshshLhlh.s......................................................pShhhuKh.WE.sSAhFS.lS.LlP..Qh..hluLThhLhLIWMh...usplhshLo.hhsL.ALFFp	.................................................................................................................................................................................................................................................-........................LT+ILsIPpSLDSWWTSLNFLGGsssC.GQNSQSPhSNHSPT..SCP.PhCPGYRWMCLRRFIIFLFILLL.CLIFLLVLLDYQGMLPVCP.LlP.....G...S....S....T.TSTG.....PC..+...TCTTP..AQGTSMaPSCCCTK.PoDGNCT.CIPIPSSWAFuKaLWEWASsRFSWLSLLVPFVQWFsGLS..PTVWL.shWMhWaWG..................................................	0	0	0	0
+4953	PF03762	VOMI		Vitelline membrane outer layer protein I (VOMI) 	Finn RD	anon	Pfam-B_3481 (release 7.0)	Family	VOMI binds tightly to ovomucin fibrils of the egg yolk membrane. The structure [1] that consists of three beta-sheets forming Greek  key motifs, which are related by an internal pseudo three-fold  symmetry. Furthermore, the structure of VOMI has strong similarity  to the structure of the delta-endotoxin, as well as a  carbohydrate-binding site in the top region of the common fold [2]. 	25.00	25.00	25.50	25.50	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.75	0.71	-11.48	0.71	-4.32	22	120	2009-01-15 18:05:59	2003-04-07 12:59:11	12	5	63	2	78	127	1	149.20	36	64.05	CHANGED	hlpsspsssaGsWtt.ptCPsGpaspGhplKhEssp....s...........D-TulNulpLaCpphs....................................................................................................sppphlhSs-usaGpWp.phpaCPtsthllGFpL+s-.ppt..tDcsussNhthhCt..........spt..ltGss..sa..GsWsssph.......................................................................Cst.G.slCGlpoplEsspu..............................................................htD.DTuLNslplpCC	...................psssss.aGsWs..p...hCPsG.aAsGFplKsEssQ....sh..s.............................DDTALNuIcLaCspst......................thlpStp.GtaGp..Wo.p..aCP.s...s.hlhuFpLRlE..s.ps.......uDsTA...sNNlpFpC...........ssst.Lp...Gsu...hsa..Gpau.p.h.p........................................Cst......ulCGlpT+lEt.pG.....hh.DDTuLNsl+hh.CC.....................	0	37	43	60
+4954	PF00434	VP7		Glycoprotein VP7	Finn RD	anon	Pfam-B_116 (release 1.0)	Family	\N	25.00	25.00	25.60	25.60	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.33	0.70	-5.52	8	4737	2012-10-01 19:08:57	2003-04-07 12:59:11	13	1	694	28	0	3775	0	272.50	76	99.95	CHANGED	MYGIEYTTILhhLIShlLlsYILKolT+hMDaIIYRFLhVlVlluslss...AQNYGINLPITGSMDTAYsNSTQ-psFLTSTLCLYYPsEAsTEIsDsEWKsTLSQLFLTKGWPTGSVYFpEYuDIsoFSl-PQLYCDYNIVLh+YssslpLDhSELADLILNEWLCNPMDITLYYYQQTsEuNKWISMGoSCTlKVCPLNTQTLGIGCpTTsssTFEpVAooEKLVIpDVVDGVNHKlNlTssTCTIRNCpKLGPRENVAIIQVGGusILDITADPTTsPQspRMMRINWKKWWQVFYTVVDYINQIIQVMSKRSRSLDoAAFYYRV	......................IEYTTlLha.L.ISl.lLLNYILKS.lTphMDaIIYR.FL..LllV.l...l.sh..s+...uQNYGlNL.PITGSMDTsY..sNS.TQp.E..s...FLT..STLCLYYPTE.........A.........uTp.........IsDsEWKDTLSQLFLTKGWPTGSVYFKEYosIssF.SlDPQLYCDYNlVLM...KYD.psLELDMSELADLILNEWLCNPMDITLYYYQQosEuNKW..ISMGoSCTlKVCPLNTQTLGIGC.TTsssoFEpVAps.EKLsIsDVVDGlNHKlslTTs....TCTIRNCKKLGPRENVAlIQVGGuslLDITADP.TTsPQhERMMRlNWK+WWQlFY.............................................	0	0	0	0
+4955	PF00522	VPR		VPR/VPX protein	Finn RD	anon	Pfam-B_100 (release 1.0)	Family	\N	20.80	20.80	25.60	25.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.41	0.72	-4.17	12	5858	2009-01-15 18:05:59	2003-04-07 12:59:11	13	3	90	10	0	5609	0	89.30	80	93.70	CHANGED	cEpsPts...pss.REsapEWlt-hlcElpcEAlpHFshcLLhtlhpahappatDp.st.....shchlpllQ+AlFlHa+pGCp.........cuRhGt	.......................M.EQAPED...QGPQREPYNEW.TLELLEELK...s....E....A.VRHF.PRsWLHuLGQaIYE...TY..GD...TW...s...G.....VEAIIRILQQLLFIHFRIG.Cp..........HSRIG.IhtpRRsRNG......................	2	0	0	0
+4956	PF03643	Vps26		Vacuolar protein sorting-associated protein 26 	Finn RD	anon	Pfam-B_4396 (release 7.0)	Family	Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking.  In particular, Vps26  assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35 [1]. This family also contains Down syndrome critical region 3/A.	20.20	20.20	20.30	20.20	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.80	0.70	-5.62	8	653	2012-10-02 22:29:00	2003-04-07 12:59:11	10	9	323	8	411	631	10	247.70	41	79.71	CHANGED	FGsss-I-IphsstcsRKhl-hct-......cGph-cthlahsGEoVoGpVslslKc.u+KlEHpGI+lEF............lGQIEhaYD+G..........................Npa-.FhsLs+ELAhPGELppspo.aPFEFspVEKs....YEoYtGsNV+LRYaLRVTlsR+h..oDlsKEhDlhV+.............sa...sshP.......................................-sN............ssIKMEVGIEDCLHIEFEYNKSKY....HLKDV.......IlGKIYFLLVR...IKIKaMElulI++EooGs.GPNsasEoETlsKaEIMDGAPVRGESIPlRlFLuGYDLTPThRslNpKFSVKYaLNLVLVDE-D	.....................................................................................................h.h.h.t......tt..h.h............................pt.h.cth.la.h.sGEslsG.............t...V.sl.p.+p..sp+l...c.....HpGI+lph...........................lGpI..........Eh...a..h..-ps..........................p..h.-..Fls.hsp-.....L.sh.P....G.....c...l.........p....s..po.asFcF........p.......lcK...........Y.EoYpGhN..V....cl+Yhl+..sol.....Rph....s-l.s.+.p.h.-.h.h...Vp............................sh.....sh...P...........................................................-.hs.................................ss.I.KM.-.V.G...I..E.-..C..L.HI.EF.EYsK..ocY..........cL.+Dl...........IlG+I...YF..LLVR.....lK...IKpMElpll++Eos.......Gs....u...s.s.h...h.p.........E.....scTls+aE......IMDGuPs+G................EoIPIRlaLss...h..p..hoPThc.s.....lN.ppFSV+aaLNLVllD--............................................................................................	0	146	219	321
+4957	PF03997	VPS28		VPS28 protein	Bateman A, Wood V	anon	Pfam-B_6317 (release 7.3)	Family	\N	20.30	20.30	20.40	20.50	19.40	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.28	0.71	-4.68	6	333	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	284	19	223	325	4	178.50	41	76.05	CHANGED	huELYAIlpsl-pLEKAYl+DslSsoEYsusCpKLlsQaKsshpplpsp....thsSIEcFscKYRLcCPsAlcRIc...............cuhPITlcc....................DpussuKsIA-lVppFITsMDuLRLNhpAhDpLaPhLs-LhsohN+lSclP..DF-s+pKlpcWLh+LspMuASDELo-sQsRQhLFDLESAYsuF.phLp	..............hAELaulIhTl-tLEKA..Yl+Dsl.os.sE......YTssCs+LLsQYKshhpp.hpst.....................ph.ss.l......-p........Ftccac.........l.-CPtAhcR.l.+...............pGhPhTlc...c........................................................s..p..u..s..s..u.phIA-ssppFIThMDsL+Lph.hAhD............p...L.aPhLp-Lhpohs+l......op..........................DFE.............s+.......tKlhpWLhpLspMpAo-ELs-p.QsRphhFDl-pAYpuF.thL..................................................................	0	74	120	184
+4958	PF04133	Vps55		Vacuolar protein sorting 55 	Wood V, Finn RD	anon	Pfam-B_25168 (release 7.3);	Family	Vps55 is involved in the secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y, but not the trafficking of the membrane-bound vacuolar alkaline phosphatase.  Both Vps55 and obesity receptor gene-related protein are important for functioning membrane trafficking to the vacuole/lysosome of eukaryotic cells [1].	23.30	23.30	23.60	24.20	22.20	23.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.57	0.71	-4.36	27	382	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	262	0	242	344	0	116.20	37	87.97	CHANGED	llhLShhluhGhlLlILuCAL..asNaaPLhsllhalluPlPshl.....spphtssssasspt..........h.-hupFlTGhlVlSuhuLPllLtHssl....IshsAhhholsGshllasoIlhahhhFsts--c	..............lluLSFhhAlGhhhllLuCAL..............apsaaPLhVlhhYlluPl.PhhI.....sp+h.s..s..ss..-.hsssu..........sh-huhF.lTshlVVSuhuLPllLAHu..s..l.........I.phsAhhhslsGshllasTIlsFhhhFtptpp.h..........................	0	61	118	185
+4959	PF00558	Vpu		Vpu protein	Bateman A	anon	Swiss-Prot	Domain	The Vpu protein contains an N-terminal transmembrane spanning region and a C-terminal cytoplasmic region. The HIV-1 Vpu protein stimulates virus production by enhancing  the release of viral particles from infected cells. The VPU protein binds specifically to CD4.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.92	0.72	-4.42	16	6152	2009-01-15 18:05:59	2003-04-07 12:59:11	14	3	58	8	0	5351	0	71.70	65	97.50	CHANGED	Mhphph.....lullulhlslIl.sIllWsl....lahcY+ch++Q....+cIpcLlcRIRERAEDSGNES-G-pEE.LssLlc.....hGasNPhh...L	.............M.sL..I.....h.u.I.V.uLlVAh.Il.AIVVWoI....VhIEYR.K.ll+Q....RKID.RLI-RIRE..RAEDSGNESEGD..pE..E.....LS.sL...VE........MGc.hs.hs..ls........................	0	0	0	0
+4960	PF03852	Vsr		DNA mismatch endonuclease Vsr	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Family	\N	20.60	20.60	20.60	20.90	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.39	0.72	-4.36	7	1075	2012-10-11 20:44:43	2003-04-07 12:59:11	10	8	981	3	248	738	161	73.40	49	47.87	CHANGED	sDhhss...tpRptsMp.ps+o+sT+PEhtLtphLaulGhRYRhpctsl.G.....pPDlVhsph+lslFlcGCFWHG+sCtht	.........................Dhhsp...tpRS+sMp...uIto+D.Tt..Eht...L.tphL..pupGl.p.aRlp....c...t....s....LP.G................+PDhVlsc.....Y+sVIFsHGCFWHtH.c.C...hh...........	0	76	158	204
+4961	PF00093	VWC	vwc; 	von Willebrand factor type C domain	Sonnhammer ELL	anon	Published_alignment	Family	The high cutoff was used to prevent overlap with Pfam:PF00094.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.35	0.72	-3.86	20	3816	2012-10-01 23:42:56	2003-04-07 12:59:11	13	320	140	1	1998	3212	3	59.00	33	11.54	CHANGED	Ch.psGphYpss-sWpss.........Cp.pCsCps........uplhCcplh..Cs.......ssCsss..................s.GECCs..hC	..................Ch.hsG..p..hYp.sG..-pWp.ss.............Cp.pCpCps..................................GpltCpp....ht....C..s............hsC.sps............................h.hssGpCCP..hC..............................	0	372	529	1087
+4962	PF02020	W2	IF5_eIF4_eIF2;	eIF4-gamma/eIF5/eIF2-epsilon	Bateman A	anon	[1]	Family	This domain of unknown function is found at the C-terminus of several translation initiation factors [1].	30.00	30.00	30.30	30.50	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.03	0.72	-4.03	77	1188	2012-10-11 20:01:00	2003-04-07 12:59:11	13	35	311	14	716	1099	4	83.00	29	12.25	CHANGED	pctphshLtulpch...h..hc...........s.phh..sh.l......tllptLY.-tDllsE-sllpWhpc...t....stpspsp..lh.cpsptFlcW.LppAEEEsp---	......................................ptplphLhulpphs....hc..........psphh..sh.l......pllpthY..-tDll.pE-sllpWhpc.....p..............h....s.tcspth.............hh..cp..s...psFlp.W.LcpAEEEsppp......................	0	217	343	531
+4963	PF03716	WCCH	WCCH_motif; 	WCCH motif 	Finn RD	anon	Pfam-B_3194 (release 7.0)	Motif	The WCCH motif is found in a retrotransposons and Gemini viruses. A specific function has not been associated to this motif [1].	20.80	20.80	21.30	21.20	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.74	0.72	-6.95	0.72	-4.45	30	1359	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	739	0	2	1020	0	24.40	64	20.75	CHANGED	PlhpsCsCPHCPRH.ppppshsppAa	......PlppPCCCPHCPRH.Kp.psMspQAH...........	0	1	1	1
+4964	PF00458	WHEP-TRS		WHEP-TRS domain	Finn RD	anon	Prosite	Family	\N	27.30	27.30	27.30	27.50	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.63	0.72	-4.29	65	996	2009-09-10 19:30:04	2003-04-07 12:59:11	15	80	141	15	582	981	8	55.30	39	11.86	CHANGED	LhpplspQG-hVRcLKucKAsKs..p.lcsAVppLLsLKtpa...KphoGp-hpPs...s..s.u	................LhpplspQG-hVRcLK.......up....K....A.sKs....p.l-.........sAVppLLsLKtph....cptp.Gpchpsst.......s.......................	0	175	232	425
+4965	PF00110	wnt		wnt family	Sonnhammer ELL	anon	Prosite	Family	Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families [1].	19.40	19.40	19.60	19.60	17.70	17.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.55	0.70	-5.23	104	10329	2009-01-15 18:05:59	2003-04-07 12:59:11	14	8	7256	1	979	7789	0	159.90	55	94.96	CHANGED	hCsplsuLs....cQpplCpppsc........hhtulscGsphulpECQaQF+pcRWNCSshstt.................................shFsp.llppG..oREoAFlaAIouAGVsauls+ACopGpl.psCuCDppt....................pststtt......................................................................WcWGGCSDNl.caGhpFu+pFlDupE........ttpssRsl..MNLHNNcAGRpsVppphcpcCKCH...GVSGSCslKT....................CWp.plssFRplGshL+c+Ycs.AhcVphpppspttth...............................................................................................p.ph+.....s..........sppDLVYl-pSPsaCpps.ph.GshGTpGRpC.............Nco.Sp.........uh-u.CshhC..CGRGasopphphsc.cCpC+.Fp.....WCChVcCcpCppphphasC+	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................+.T....................CWh.pL..P.s..F..R..s..VGDsLKDRFDG.A.SR.VMhsNsshp.t...ss.p.p.spsssptsst..................................................................................................+pRYpFQL+Pa.NP-HK............sP.............GsKDLVYLEsS..P.s..FCEK..NP+..............L.........G....I....G....THG.......R..tC..............................NDT...SI.................GVD..G..CDLMC..CGR.G.Y+T.p.p.h.hl.lE.RCs.......................................................................................................	1	210	287	607
+4966	PF01822	WSC		WSC domain	Bateman A	anon	[1]	Family	This domain may be involved in carbohydrate binding.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.83	0.72	-4.05	162	2216	2009-09-11 06:24:10	2003-04-07 12:59:11	14	209	242	0	1812	2200	48	80.00	26	17.70	CHANGED	YhGC......as...........-s................hhsss.thssssho...sptC.hshCt....tt...u.ash......sulp..up...pCaC..Gsshsstt.t.sspt..............Cs.hsCs.Gss...s......ph.CGG	................................................hGCap.....................-s.......................tt.thh...st...ths.ssshT.......sptC.hsh.Ct..........tt......u..as.a............uGlp...hup.......cCa..C.........G..s...s...hs...s..s.s...tt.s.stsp....................C....s....hs.Cs..Gss....s..........ph..CGG..................................................................	0	824	1197	1552
+4967	PF02165	WT1		Wilm's tumour protein	Mian N, Bateman A	anon	IPR000976	Family	\N	19.60	19.60	21.80	20.50	16.90	16.80	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.16	0.70	-5.32	8	147	2009-09-10 17:23:11	2003-04-07 12:59:11	10	10	53	6	33	118	0	217.70	64	67.01	CHANGED	MGSDVRDLouLL...PPVSSLsuuuGuC.ulPVuGusQWAPlLDFH.PGS.PYuSL..............usHSaIKQEPoWG.uuDPaE...DPHCGLuA.FTVHFSGQFTGT.GsCRaG.AFG...........................pPssuQuRMFPNuPYLPuClDSsPshRNQ.GYusVAhDGsPSYGHTPSHHsuQFoNHSFKHEDslS.QooluEQQYsVPPPVYGCHsPoDoCsuSQALLLRNsYNS.DNLYQMsSQLECVTWNQMNoLuSohK.................uHuuuYEoDspos..PhLhSCSuQYHIHTHGV..FRGlQDVRRVPGlsPslVRS.SEooEKR	...................................................................................................s..HShIKQEPsWs.ss-Phc...-.ps.LuA.FTlHFSGQFTGo.usCRaG.sFG............................pss.t..s..RMFssssYLssCh-s..s.RNQ.GYusVsFDGsssYGHTP..oH.HssQFssHSFKHEDshu..QQsohG.-.QQYsVPPPVYGCHTPoDSCTGSQALLLRsPYsS..DNLYQMsSQLEChsWN.hN.LuuolK..................................................................sHuoGYES-spos..PhL..CuuQYRIHTHGV..FRGIQ.DVRRVPGlAPslVRS.SEosEKR.................................................................	0	2	5	15
+4968	PF03303	WTF		WTF protein	Mifsud W	anon	Pfam-B_4183 (release 6.5)	Family	This is a family of hypothetical Schizosaccharomyces pombe proteins. Their function is unknown.	25.00	25.00	64.20	62.40	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.78	0.70	-4.96	8	19	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	1	0	19	27	0	238.50	41	80.87	CHANGED	MKNNYTSLKSSlDEtDEhKTDHEIDLEKG.LPEYsSEEEusLPPYSDhu+l.......Ss.......sPN....................sHRcpcsScSsDNpos..LlKLLIShlulhVlNhsA.lCh.saKcuhFtcautu-hVLFGlhsh.lCslshIhLhYFYETWsKAV....KVTll..................shuhGLhshp+chhlhhahhah..IlChlLFsshppGpL.ls+uhltS.....sColSAtllhhl.sVsIPhaphcphhstLhpV.hlppshsls	..MKNNYssL+SslDEtsp.hKs......DpEIDLEKG.LPEYsSEEEuTLPPYSDhupl..........us.......sPN..............................s+Rcsc.ssco...scNuss..LlKLLIShhslhllNhsA.lChL.a+cuhFpsauhsphslFGhaCh.sCslshIhLhaFYETWTKAV....Khslh...................................................shuhGlhp.h+chhshhahhhh..lhphhLhshhppstLsL.puhltu.....pCSluAtlhhhl..lhl..ahhcphh.t.hps.hlppshh.................................	0	19	19	19
+4969	PF04932	Wzy_C		O-Antigen ligase	Moxon SJ, Bateman A	anon	Pfam-B_5033 (release 7.6)	Family	This group of bacterial proteins is involved in the synthesis of O-antigen, a lipopolysaccharide found in the outer membrane in gram-negative bacteria. This family includes O-antigen ligases such as E. coli RfaL [1].	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.45	81	1431	2012-10-01 22:04:45	2003-04-07 12:59:11	10	29	1205	0	366	4539	2057	165.80	18	32.83	CHANGED	hshllh..hhslhhotSRuuh...luhhlshhhhhhhhhtthhtth................................................hhhhh....hlhshslsshh...............................................................................................................................tphhhplhstststs................................stRh.t.happuhphhtpp.Ph....hGhGh..................hht.h.......hh.hh.sthhtpsHNhalphhschG.lhGhlhhh	...................................................................................................................................................................................................................................................h...llh..hh.slh.h.o.tSRu..u.h.......l.u..h....h..l..s...h....h...l.....h....h.....h......h........h....h....t......h......t.....t...t..t...h...................................................................................................hh.hhh............hlhs..hhl.s.h.sh.......................................................................................................................................................................................................................................................h.p....p...h...h...t..p..l...h...p.tt.t..p..s..t.........................................................................................................shRh.t..ha....p....s.ul.p....h..h.....p...c....p...Pl......................hG..h.Gh..sth.....................................tthh.p.t.h.............h.h.....t...h..h..h.....t...h..h....t....p..s..HN.hL.phhsptG..ll.Gllhh.h.............................................................................................................................	0	159	261	325
+4970	PF00739	X		Trans-activation protein X	Bateman A	anon	Pfam-B_458 (release 2.1)	Family	This protein is found in hepadnaviruses where it is indispensable for replication.	21.50	21.50	21.90	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.79	0.71	-4.27	5	5949	2009-09-16 23:40:58	2003-04-07 12:59:11	14	7	78	2	0	4549	0	103.30	87	89.74	CHANGED	MAARLCCQLDPARDVLCLRPVGAESRGRPlPGPhGuLPuuuuSAVSoDHGAaLSLRGLPVCAFSuAGPCALRFTSA..RRMETTVNsHp.LsKsL+KRTLGLSuMSToDL.EAYFKDpLFT-WEELGEEhRLpIFVLGGCRHKLl	....................RhhCQLDs.sRDVLCLRPVuAESpGRPhsGshGslsssSsssVsssaGuHLSLRGLPVCAFSSAGPCALRFTSA..Rp..METTVN.....A...+....p........L....PKV....LHKR........T........LGLS.A.MSTT.DL...EAYFKD.ClF.KDWEELGEEIR......Lhl.FVLGGCRHKLV...............	0	0	0	0
+4971	PF00860	Xan_ur_permease	xan_ur_permease; 	Permease family	Bateman A	anon	Pfam-B_1593 (release 2.1)	Family	This family includes permeases for diverse substrates such as xanthine Swiss:P42086, uracil Swiss:P39766 and vitamin C Swiss:Q9UGH3.  However many members of this family are functionally uncharacterised and may transport other substrates. Members of this family have ten predicted transmembrane helices.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.20	0.70	-5.98	20	15557	2012-10-03 01:44:59	2003-04-07 12:59:11	15	19	3998	1	2877	9790	2601	366.40	23	85.08	CHANGED	tphlhhGLQahhuMauusllVPlllutu..........t..lhuhshlsuGluTllQsh....hhGhplslhhGsSFsals......hhhhshG.............shslsulhGullluullhhlluhhGhh.hLh+hhPPlVsGsllhlIGLuLs.luhsthuss....ssu....hsssphhtlulsslshslhhshh...tpshhpphulLlGlhsGalluhhhG..hlshss...............ltstsahths.sh.ausPh......hshslllshhslsllslhEslGshhuluplssppht....p.slp+uhhu-GluolluuLhGu.hPsToaupNlGllslT+lhSphlhhsAullhllhGlhsKluuLhssIPssV.lGGshllhaGhlhuuGlphLppschc..pscNlhIlulolslGlulsth.hh	............................................................................................t..tlhhGlpph.lsM..hhshl.l.......s.Ph.ll...uts........................................t...h.........lh..sss....h.........l..suGl....uoll.sh...............hssh...l.shh...Gh...uhs..hhs...................hhhls.hG.............................................s.h.sh.t....s...............h....h...uu.s....hltu....ll....h.h....l....ls....h....h.....t....h........h...........h..........l.h.c..h.l.P.....ssl.......p.s....s..l.......s....hsIG.....L.L.h................l......u.....l.....p.......s....s.......u......h......h......h.................................ps..........................h.....s....................s.............p........................h....................h...................h..........u............h...........l......h..............h........l......h....s......l....h...l...thh............................hps..h..h...h..h...h......u...l.L..lu..l.lssh...ll.uh...........h...hG........hl.......s..h.ss............................................................lt.ps.s..h....h....t..h....s..............h..t...h....s.hsh..........................h..s....h...s.....h...l....h...s....h...h.s.h...h...l.ls..hh-................sh..Gsl..h......u..l...u......p...h...ss....h.hpt......................pl.p.+...u...lh.u...Duluohlu.uhh.Gs..sssT.s.a.s....Ess..........u.sluhs...........st..s...hhsus...l.hsl.lh.uh...h.s.hh.u..slhth.lP............s...........s.........l.....hu........u........s........sl.l...........h.h.Ghlh.hsu....lph.l.s.h..s..c..hs...pshs.hh.l.s.ulhls...huhuls.h...hh............................................................................................................................................................................	0	745	1589	2296
+4972	PF04921	XAP5		XAP5, circadian clock regulator	Bateman A	anon	Pfam-B_4702 (release 7.6)	Family	This protein is found in a wide range of eukaryotes. It is a nuclear protein and is suggested to be DNA binding [1,2]. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light [3].	25.00	25.00	29.20	28.20	23.60	23.10	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.56	0.70	-4.80	26	325	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	232	0	217	305	9	237.70	43	71.22	CHANGED	KK+p+pppscLSFssD--E.........................................pppspspttp.cppp..pt.sh.............................p++lsKNPsVsTs.aL.D+sR-ccEpptR-pLRcEaltpQpt...............lKspEItIsFsYaDGosppt.sV+hKKGsoIhtFLp+spc.ht..........tc.....hpEh+psSsDsLMhVKpDlIlPHHYoFY-FIhsK..spGKoG.sLFsFDscc.................................shphhs-hpspc--opssKVV-RpWYERNKHIFPAS+WE......Y-PtKsasp.hhp	....................................................................................................................t.tttththttLSFs.--cctt.....................................................................................................tppptttt.t..........t.....t...................p...............................p+KluKNPs..V-TS..FLPD+-REccEsphR...........EcLRpEW.tpQEplKsEEIpITFS...........YW........D.....GoGHR...+....sVc..............hKKGs......oltpFLp+shchLt..................p-..............FpEL+ss.uV-pLMalKEDLIIPH....HaoFY..-FIlsK...ARGKS.........G..PLF.sFDV+-..........................................D.lRh.l.sDAssEK-ES.......HAGKVV.RpWYE+NKHIFPASRWEs.....YDPpKcac+Ysh.p..........................	0	80	119	170
+4973	PF02625	XdhC_CoxI	DUF182; 	XdhC and CoxI family	Mian N, Bateman A	anon	COG1975	Domain	This domain is often found in association with an NAD-binding region, related to TrkA-N (Pfam:PF02254; personal obs:C. Yeats). XdhC is  believed to be involved in the attachment of molybdenum to Xanthine Dehydrogenase ([1]).	23.80	23.80	23.80	23.90	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.98	0.72	-4.36	129	2575	2009-01-15 18:05:59	2003-04-07 12:59:11	11	15	1586	10	764	2086	952	70.30	30	22.01	CHANGED	tphhppspss....sLuTllpspGSsPRpsGupM..llps-G...p.hhGolu.GGs....lEtplhppApphl..psup.....sphhpash	............t.thhtpspss....sLsTllcspGSsPR.ps.G.ApM.lVpsDG............p...hhGol.u.GGs.................lEtplhpc..A.t.....p.h.l.....tssp......sphhph..h......................	0	243	509	653
+4974	PF03894	XFP		D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	Wood V, Bateman A	anon	Wood V	Family	Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22 [1]. This family is distantly related to transketolases e.g. Pfam:PF02779.	21.20	21.20	21.70	22.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.19	0.71	-4.68	6	1182	2012-10-02 16:07:47	2003-04-07 12:59:11	10	11	939	16	425	1121	49	168.90	47	22.78	CHANGED	spsLGpYlRDll+hN..spsFRlFGPDETtSNRLpusaEVTcRtWhpphhs.s.-...l.sctGpVsEhLSEHpCEGWLEGYLLTGRHGhFuSYEuFl+lVDSMlsQHuKWLchs.p-lsWR+cIuSLNllsoSsVW+QDHNGFoHQDPGhlsslLsKKs-...llRlYLPsDANoLLAVsD+Chpo	................................................p.lGpal+-lhchN.....scs.....FRlFGPDETtSNRLt.ula-sT...s+..tW....t...p.hh.s...t.s-..thhss..sGpVh.E.LSEHt.spGaLE....GYlLTGRHG..hFuoYEuFl+llDSMhsQ....HsKWL.chs.p-.......lsWRpslsSLNhlhTSpVa+QDHNGaoHQDPGhlshlhs.K.p.s-...llRlYLPsDANoLLulh-+sh+....................	0	108	256	360
+4975	PF03469	XH		XH domain	Bateman A	anon	Bateman A	Domain	The XH (rice gene X Homology) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2.  The molecular function of these proteins is unknown.  However these proteins usually contain an XS domain that is also found in the PTGS protein SGS3. This domain contains a conserved glutamate residue that may be functionally important.	22.20	22.20	25.60	33.50	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-4.49	12	174	2009-01-15 18:05:59	2003-04-07 12:59:11	9	12	21	0	109	154	0	119.60	41	25.99	CHANGED	KRMGcLs.csFhcAspp+hs.....tp-sp.pAs.lpshWccplp-ssWpPa+h................ssph.tEllsE-DEcL+pLKp-hGE-VYstVppALhEhNEaNsSG+Y.ssELWNa+-sRKATLcEslshhhp...phpphKR+R	..................................................KRMGELD.+sFhpAspp+hs.............tc-sp.pAs.LsShWpppl.+s..ssWHPFKhlh..................................sssptpElls--DpKLppLKp-aG--lapsVtpALhElNEY..........N.s.SG..........RYsssELWNa+EsRKAT.lcEslpalhp...phct.+p+................	1	16	53	82
+4976	PF03468	XS		XS domain	Bateman A	anon	Bateman A	Domain	The XS (rice gene X and SGS3) domain is found in a family of plant proteins including gene X Swiss:Q9SBW2 and SGS3 Swiss:Q9LDX1.  SGS3 is thought to be involved in post-transcriptional gene silencing (PTGS). This domain contains a conserved aspartate residue that may be functionally important. The XS domain has recently been predicted to possess an RRM-like RNA-binding domain [1] by fold recognition.	25.00	25.00	26.60	26.00	24.20	21.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.60	0.71	-4.15	12	211	2012-10-02 20:46:34	2003-04-07 12:59:11	9	16	28	2	131	198	0	117.00	28	20.35	CHANGED	pc-haVWPWhGllsNsssphp.cs+..sG.uusphcpcluc..FsPhcVpsL.Wspp.GasGhuIVcFupsWsGFcsAhth-caF-tptpGK+DWtptp..........t.ptsclaGWsA+t-DYpusshl	.........t.p-hhVWP.hsIlhNsstph..pt..ssp..hGhus....pclhcphsp...Fss.h.+.sp.sl....astp....GHpGhullcFspshsGappAhphccpFptpspG+c-Wtppp......................t..ttptlYGalApt-Dhp............................................	0	16	80	114
+4977	PF04555	XhoI		Restriction endonuclease XhoI	Kerrison ND	anon	DOMO:DM04409;	Family	This family consists of type II restriction enzymes (EC:3.1.21.4) that recognise the double-stranded sequence CTCGAG and cleave after C-1.	25.00	25.00	71.30	35.80	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.14	0.71	-4.90	6	48	2012-10-11 20:44:44	2003-04-07 12:59:11	8	2	42	0	13	50	2	174.20	43	80.90	CHANGED	pKQh-oG+sDpGERuGVTuGKNMDGFlsLlhsllptNGLucA-Ia.ps+shLTLPGYFRPTKLWDlLVlp.....cGpLlAAVELKSQVGPSFGNNFNNRsEEAIGTAaDlWTAaREtAFGcp..RPFlGWLMLVEDsPcS+puVp-sSPHFPVF.EF+GASYlKRY-lLCpKLlhEpLYToAslIsSs+susttGcac-hSp	.........................tsGctDtGpRuuVTuGKphDGFhtLlh-llptsGlscspla..ppthhsLPGYFRPoKpWDLLVlt.....cGpLlAAlEhKSplGsSFGNNFNNRsEEAlGoAhDlaTAa+EstaGpp..tPalGalhllEDsspSppsV+..s.p.p.PH.Fsl..-F................cGsSYhcRYclhCp+LltEpLYssusllhu.t.t...........s.............	0	4	8	12
+4978	PF00193	Xlink		Extracellular link domain	Sonnhammer ELL, Bateman A	anon	Swissprot_feature_table	Domain	\N	21.00	21.00	21.00	21.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.40	0.72	-3.90	12	1651	2012-10-02 16:37:33	2003-04-07 12:59:11	12	106	63	14	677	1338	95	93.40	40	15.67	CHANGED	GhVFahpsss...ploFpEApptChppuAplATstQL.AAacs.Ga-pCsAGWLuDtoVRYPIspPRpsCuGsp...sGVRsh.......Gh..sspppYDsYCa	..............................GhVFahpssp....ploFpEAppsCt.pp.uApl...AossQLhuAact.G.h-p.CsAGWLuDu.oV..R.YP.Isp..P..R...t..tC.uGst............sGVRoh........Gh.....ssp.p.p.a.DsYCa.....................................	1	60	115	287
+4979	PF00867	XPG_I		XPG I-region	Bateman A	anon	Pfam-B_776 (release 3.0)	Family	\N	22.50	22.50	22.50	22.60	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.27	0.72	-3.93	207	2052	2012-10-01 19:52:02	2003-04-07 12:59:11	13	37	569	21	1236	1927	247	87.50	31	14.55	CHANGED	chh.Glsal.AP..hEAEAQsAhLs....ppGh......lsulho-DsDsLlF....Gss....ll+ph.....p.tth...................p.hph...tphhpt....ht..l.sp.cp....hlshslLs.....GsD	...........................t.hhGlsals....A..P..hEA-AQCA.hLt..............cp.Gh......Vsulh..op..DoDhLlF......Gss.....tllp.phs......t.t......................................................................................th.lphhph...p..cl.hpt..........hs...h.sp...pp......hlslslLhGsD..........................................................................................................................	0	441	726	1045
+4980	PF00752	XPG_N		XPG N-terminal domain	Bateman A	anon	Pfam-B_491 (release 2.1)	Family	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.15	0.72	-3.75	10	1710	2012-10-03 20:43:45	2003-04-07 12:59:11	12	35	531	21	1161	1748	220	97.30	29	15.40	CHANGED	MGI+GLhslLpshu....RpsclEsapG..+pLAIDuShaLYQFLpuVRpptGsslps.....sSHLhshFpRhp+lhpaGI+PlaVFDGssP.sLKppslsKRppRRpcs	.....................................MGlp.u.Lhphlpshs...................c..t.h..p..........l....c....p.hp..G.............pp..lAl..............D..u..........sha........l...a..p....h.....h.h..u...s...p...t.p.....u.p.shts.................................sa..l...h..s....hhhR.ht.p.L.l...p.h.sI.+P.l.a...........VF..DG..t..s.s...hKpppht.cRppp+t..t.................................	1	407	670	969
+4981	PF01834	XRCC1_N		XRCC1 N terminal domain	Bateman A	anon	SWISS-PROT	Domain	\N	20.70	20.70	20.80	21.10	18.80	20.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.13	0.71	-4.74	3	182	2012-10-03 19:46:52	2003-04-07 12:59:11	11	9	89	13	107	163	1	131.20	46	23.24	CHANGED	MPEISLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGu..TAGEQDYEVLLVTSSFMSPSESRSGSNPNRVRMFGPDKLVRAAAEKRWDRVKIVCSQPYSKDSPYGLSFVRFHS	.............Ms.lphpcVlSh.SSpD..s.pas.s-NLLp.s.-..s.......+...p.Whss.p.s.t.p.t..p..hpV.LQLE+..t...IptlDlG.NpGuAFlpl.VGpSuhs......-psa.sLLssoohMSPs-S..+sGpN.spVRhF...ssscllpssupcpWDRl+llCoQPas+c.saGLuFl+h+.....................	0	39	46	72
+4983	PF02162	XYPPX	Rhodopsin_C; 	XYPPX repeat (two copies)	Mian N, Bateman A	anon	IPR000216	Repeat	This repeat is found in a wide variety of proteins and generally consists of the motif XYPPX where X can be any amino acid. The family includes annexin VII Swiss:P24639, the carboxy tail of certain rhodopsins Swiss:Q17094. This family also includes plaque matrix proteins, however this motif is embedded in a ten residue repeat in Swiss:Q25460. The molecular function of this repeat is unknown. It is also not clear is all the members of this family share a common evolutionary ancestor due to its short length and biased amino acid composition.	19.00	5.00	19.00	5.00	18.40	4.90	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-6.70	0.72	-4.32	7	228	2009-09-16 16:02:34	2003-04-07 12:59:11	12	13	64	0	33	227	0	14.50	85	15.07	CHANGED	GY....PPQGYPPQuhPPQ	.......uY....PP..Q.G.YP.P..QG.YPPt......	0	20	27	32
+4984	PF04690	YABBY		YABBY protein	Mifsud W	anon	Pfam-B_5698 (release 7.5)	Family	YABBY proteins are a group of plant-specific transcription involved in the specification of abaxial polarity in lateral organs [1,2].	21.00	21.00	21.00	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.27	0.71	-4.01	6	396	2012-10-02 14:16:02	2003-04-07 12:59:11	8	5	153	0	111	371	33	129.80	45	77.58	CHANGED	sslhsso-+lCYVpCsFCsTILAVSVP.sSLaplVTVRCGHCTsLLSlslshts....phLsu.sp................lhpshpspspshs..hhppcssosptss..h........Spsppc-hP+.....sRPPEKRQRVPSAYNRFIKEEIQRIKAsNP-ISHREAFSsAAKNWAHFP+IHFGL	..................................................................................................................................................................CsTlLA..VulP.hpp...lh..phVTV+CGHCsNL...lsht............s.................................................................t........t...t...........t..t.p.....t......................................p.tp........Pc.......hs+P.P..EK+p.RlP...SAYNRFhKEEIQRIKAsN....P-IsHREAFSsAAKNWAp.........................................................	0	20	72	95
+4985	PF03895	YadA_anchor	YadA; YadA_C;	YadA-like C-terminal region	Bateman A, Sandt C	anon	Sandt C	Family	This region represents the C-terminal 120 amino acids of a family of surface-exposed bacterial proteins. YadA, an adhesin from Yersinia, was the first member of this family to be characterised. UspA2 from Moraxella was second. The Eib immunoglobulin-binding proteins from E. coli were third, followed by the DsrA proteins of Haemophilus ducreyi and others. These proteins are homologous at their C-terminal and have predicted signal sequences, but they diverge elsewhere. The C-terminal 9 amino acids, consisting of alternating hydrophobic amino acids ending in F or W, comprise a targeting motif for the outer membrane of the Gram negative cell envelope. This region is important for oligomerisation [1].	21.70	21.70	21.70	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.49	0.72	-3.97	110	2384	2012-10-03 10:38:27	2003-04-07 12:59:11	10	481	927	35	313	2186	103	77.90	30	8.25	CHANGED	hc+csp...uGlAuAhAhuul..Ppssh..sGphsluhGsGsYpGpsAlAlGsuths.ssp..hhh+husu..........sopussususGsuapW	..........................cpchp...uGhAuAhAhuuL....sQs.t......sup..huhGsGsYp...GpsAlAl.Gsuhhs..ssp.......hhh+husoh..........sopu..chususGsuapa...............	0	79	157	241
+4986	PF02699	YajC	DUF219; 	Preprotein translocase subunit	Mian N, Bateman A	anon	COG1862	Family	See [1].	21.00	21.00	21.00	21.50	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.60	0.72	-4.31	176	4454	2009-01-15 18:05:59	2003-04-07 12:59:11	10	3	4168	1	876	2416	1646	83.30	32	76.43	CHANGED	sh.hht.ll...h.l.lhhslhYFllIRPQp...K+tK....c+pphlssLp+GDcVlTsGGlhGplspl..s-shlhl-lus.......s..lclclp+su.Isplh	.............s.h...ll..hl.l..lhhslh.Y...Fh..hl.....R.PQ.p.....K+tK.......c+.pp....hh.suLp+GDcVlTtGGlhGpls.cl..........ccs..hlslclss........s...sclphp+s.ulspl...................	1	300	579	737
+4987	PF04073	tRNA_edit	YbaK;	Aminoacyl-tRNA editing domain	Finn RD, Eberhardt R	anon	manual;	Family	This domain is found either on its own or in association with the tRNA synthetase class II core domain (Pfam:PF00587).  It is involved in the tRNA editing of mis-charged tRNAs including Cys-tRNA(Pro), Cys-tRNA(Cys), Ala-tRNA(Pro)[2-5].  The structure of this domain shows a novel fold [1].	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.15	0.71	-4.27	91	9872	2009-01-15 18:05:59	2003-04-07 12:59:11	10	31	4219	22	2098	6622	1977	122.00	22	38.51	CHANGED	p.sstoh.pchuphhs.........hsspph..sKslllcs...................tcsp...hhlslltuspclshpplpphhu....p.clphA..stccltphh.G....hthGslsPhuh.........ttl.plllDpslhshp.p..lhssuspsstplplsstphhch	................................................................ph..tph.sp.h.h.s....................hs......pph...hKoLlhps.................................................scsp.......hllsll..us.p.cls.........p.K.l....tph..h......G..............s..p..c......lphA......s.cc.l...p.p..h..s....G................hhhGuluP.lGh............................pptl..lllDps....ltp..h.....s...p.......lhsuAsp.pshplhhsstphhp.h.......................................................................	0	669	1310	1755
+4988	PF02392	Ycf4		Ycf4	Bashton M, Bateman A	anon	Pfam-B_1026 (release 5.2)	Family	This family consists of hypothetical Ycf4 proteins from various chloroplast genomes.  It has been suggested that Ycf4 is involved in the assembly and/or stability of the photosystem I complex in chloroplasts [1].	25.00	25.00	30.00	29.50	20.20	22.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.08	0.71	-4.96	59	709	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	670	0	68	562	136	177.50	64	96.24	CHANGED	p.sctlhpp.IhGSRRhSNYaWAhllhlGulGFLLsGlSSYltp...............sLlsh.........hsspp.......llFlPQGlVMsFYGluGlhlShYLWhsIhWsVGuGYNc........................................FsKppGh..................................................lpIFRWGFPGKNR+IplpaslcDIpuI+l-l.....pEGlsP+R.....slYL+lKGpp-IPLTRl..GpP.lsLsElEppAAELA+FLpVslEG	.........................................................................R.ScplWIE.IsGSRKhSNFhWAhILFLGSLGFLLVGhSSYLG+.........NLIsl..........hs.S.QQ......................IlFhPQGIV.MuFYGIAGLFISSYLWCTIhWNVGSGYs+........................................FD+K-.GI..................................................VCIFRW..GF..PGhNRRIFLRFhhKDIQSIRlEl.....+E..G.l..s.RR.......lLYMEI+G.pt.s..IP.LTRT..s-N..lT.REIEQKAAELAhFLRVPIE..............	0	16	41	59
+4989	PF01737	Ycf9	YCF9; 	YCF9	Bashton M, Bateman A	anon	Pfam-B_2211 (release 4.1)	Family	This family consists of the hypothetical protein product of the YCF9 gene from chloroplasts and  cyanobacteria. These proteins have no known function.	20.90	20.90	21.70	22.10	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.82	0.72	-4.53	35	1482	2009-01-15 18:05:59	2003-04-07 12:59:11	12	1	1444	17	54	419	120	57.60	81	94.87	CHANGED	lFQlslhALlhlSFlLVVGVPVlaASPpsWspoKsllasGuulWluLVhlVGlLNShVs	..........AFQLAVFALIATSSlLLISVPVVF....ASPDGWSSNK..N....VVFSGTSLWIGLVFLVGILNSLIS.........	2	11	34	46
+4990	PF03795	YCII		YCII-related domain	Yeats C	anon	Yeats C, Bateman A	Domain	The majority of proteins in this family consist of a single copy of this domain, though it is also found as a repeat (Swiss:Q9AJZ7). A strongly conserved histidine and a aspartate suggest that the domain has an enzymatic function.  This family also now includes the family formerly known as the DGPF domain (COG3795). Although its function is unknown it is found fused to a sigma-70 factor family domain in Swiss:Q9A8M4.  Suggesting that this domain plays a role in transcription initiation (Bateman A per. obs.). This domain is named after the most conserved motif in the alignment.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.94	0.72	-3.79	26	4283	2012-10-02 00:20:33	2003-04-07 12:59:11	9	20	2247	3	1546	3526	595	97.20	23	86.30	CHANGED	Mhasllshspsssh.....ppptshhssHlsaLcpLtppGthlsu................GsthshDG..st.....GGhhlh-ssshspApphupsDPhsps..Gshpth.lh.......pap	...............................................................hahl.h.h...t..p..sst.................ppptshh..s.sHh...shl..p....p...l....t....cpG..p.llsu..............................Gs...h..s...s...s..D....u..........s.....t........t......hG.uhh.l.h..c.sp...o...h....-...p....A...p....thupp...DP..a..s..ts....G...h.h..p.....h.lh.h.............................	1	496	968	1287
+4991	PF02182	SAD_SRA	G9a; YDG_SRA;	SAD/SRA domain	Iyer LM, Aravind L, SMART	anon	Alignment kindly provided by SMART	Domain	The domain goes by several names including SAD [1], SRA [2]  and  YDG [3]. It adopts a beta barrel, modified PUA-like, fold that is  widely present in eukaryotic chromatin proteins and in bacteria [4]. Versions of this domain are known to bind hemi-methylated CpG  dinucleotides and also other 5mC containing dinucleotides. The  domain binds DNA by flipping out the methylated cytosine base from  the DNA double helix [5].The conserved tyrosine and aspartate  residues and a glycine rich patch are critical for recognition of  the flipped out base [4][5]. Mammalian UHRF1 that contains this  domain plays an important role in maintenance of methylation at  CpG dinucleotides by recruiting DNMT1 to hemimethylated sites\	associated with replication forks [2]. The SAD/SRA domain has been combined with other domains involved in the ubiquitin pathway on multiple occasions and such proteins link recognition of DNA  methylation to chromatin-protein ubiquitination [4]. The domain is also found in species that lack DNA methylation, such as certain apicomplexans, suggestive of other DNA-binding modes or functions [4]. A highly derived and distinct version of the domain is also found in fungi where it is fused to AlkB-type 2OGFeDO domains [6]. In bacteria, the domain is usually fused or associated with restriction endonucleases, many of which target methylated or\	hemi-methylated DNA [4].	20.50	20.50	20.90	21.10	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.06	0.71	-4.92	34	554	2012-10-08 19:26:47	2003-04-07 12:59:11	12	47	169	32	371	572	41	149.00	37	23.53	CHANGED	p+clGslPGlpVGDhFhaRhEhsllGlHtsphuGIDhhpsps..........hAsSIVsSGGY-.DDpDsuDsllYTGpGGps.t.tpp.....pspDQcLpcGNLALtpSh...............cptssVRVlRGhcptpp.........psthYhYDGLYpVpcaWh-pGpsG.htVa+a+LpRh...sGQ	.......................................................................t.phhG.lPG..l.VGshahhRhphs.sGlHtshh....u....G..I.cttssps....................................AhSlVh....u......GG...Yc...DDh.D.pG-.hhYTGpG...Gps.hs.s.s+...................pspDQpL.....p.p..s.NhALthsh................c.pspPVRVlRuh+stpp...................hts.pts..hpYDG..lY+........VhchW...-h.....G..pp..G...hhVa+ahLhR.ss......................................	1	105	204	288
+4992	PF04794	YdjC		YdjC-like protein	Waterfield DI, Finn RD	anon	Pfam-B_5925 (release 7.5)	Family	Family of YdjC-like proteins.  This region is possibly involved in the the cleavage of cellobiose-phosphate [1].	24.00	24.00	24.30	24.20	21.80	23.90	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.77	0.70	-4.92	114	1651	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	1420	8	307	1052	228	240.90	32	92.26	CHANGED	+cLIlsADDFGlotuVNtuIlcuacpGlloSsolMsssPuh.pcAsphs+.p..ts.....tls.lGLHlsLos..GhP.l....h...pthssLlst..............p.GhFhphh........hthh.tphshcpltpElpAQlcpFhs.hGhsssHlDuHpHsH.hhPslhsslhplu.pchsl.....sh.Rh......shp.h................................ht.hstthptphtptGlshss.h...............hhthlhphhpphsp.t..................ssElMs.HPuhh......sst.lhshssh.....stpRtpEhphLsuspltthlppp	....................h.hLIlNADDFGLocuhNhGIlcuhcsGl...loSTohhsNssuh..c....cA.....l...p....Lu+....c....hP.................sLs..lGhHhsLTh..Gc.....P..l............sthPuLsc...............s.G..hhtchh...............p......hh...........p....s.s...l..s.h--l...ppEltuQhp+Fhp..hGt.pPoHlDoH.+H....l....H....hhP.p...lhsllhc.....hA...tchul..........sh..Rh............stpsh................................h.h............lps.spthpstah...sp.slspst.............................hhphLpphhpp.htp............................shElMs.HPAal..............-p..lhp..p.S.ua........shsRhpELclL.sSsplpthltp.p...................................................................................	0	103	183	242
+4993	PF00399	PIR	yeast_PIR; 	Yeast PIR protein repeat	Finn RD	anon	Prosite	Repeat	\N	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.97	0.73	-6.38	0.73	-4.44	17	804	2009-01-15 18:05:59	2003-04-07 12:59:11	14	15	57	0	500	869	0	17.80	68	21.99	CHANGED	suAlSQIsDGQlQAToss	...tuAVSQIuDGQIQATTpT......	0	82	223	407
+4994	PF03366	YEATS		YEATS family	Mifsud W	anon	Pfam-B_2273 (release 6.6)	Family	We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity	22.00	22.00	22.10	22.20	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.94	0.72	-4.26	63	798	2009-09-11 12:00:18	2003-04-07 12:59:11	11	14	314	7	532	728	2	83.10	35	19.08	CHANGED	oHpWslal.........cshss.....................c.c..h.uphlcKVpFpLH.toFss.Ph.RslcpP....PFclsEpGWGEFpltIclaahs......ptp.hsl.HpLplpttshp	.......................THpWp..VaV.........+shpp....................................................................................p..c...l.stalcKVhFpLH...Sass.Ph........R.s......l...ccP..........P...FclsEsGWGEF.l.IclaFts......pt+.lslhHpLpLt.pt..s...........................	0	160	267	417
+4995	PF03543	Peptidase_C58	YerHae_surfAg; SurfAg;	Yersinia/Haemophilus virulence surface antigen	Griffiths-Jones SR	anon	PRINTS	Family	\N	22.90	22.90	23.10	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.42	0.71	-4.83	14	182	2012-10-10 12:56:15	2003-04-07 12:59:11	9	21	106	1	40	172	1	170.80	19	15.90	CHANGED	Rsoh...ucaGscsshhhsts..............ts........GlC.uLsAcW....lp.css..spshhspLh.uut.cGp...hphpphhshpphphc..tsttsptph.................phppshLpctGlpPptc.hsht................tsupsshsshlpsIhcsGspphhsh+h....sphuuHslAstsp.spp.lsFFDPNaGEFohsscpp.....tsshapp.hhphpptspphhpllshchp	............................................................................................................................................................................................................................................................................................thp..tpshstllptlh.cssu.pshhs.hh......hptsuHAhAs...h...s...........p...sp....p...h......sFFDPNh..GthpFsstc....pFtta.hpta.htp.h....................t....................................	0	12	23	31
+4996	PF03545	YopE	Yers_vir_YopE; 	Yersinia virulence determinant (YopE)	Griffiths-Jones SR	anon	PRINTS	Family	\N	25.00	25.00	26.00	59.50	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.14	0.72	-4.03	8	184	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	159	8	7	96	0	69.90	55	15.70	CHANGED	EpLt+-HspLAoGNGuLRSLsTuLpGIpcGSphpphps.AupLL-psluGIsLQQWGTsGGpAochVsSA	..poLpcNapchASGNGPLRSLhTsLQsLschscscpLp-hsosLhNhplGuhtFSQWGT...sGGsspcalscA.............	0	2	3	4
+4997	PF03887	YfbU		YfbU domain	Bateman A	anon	COG3013	Domain	This presumed domain is about 160 residues long.  It is found in archaebacteria and eubacteria.  In Swiss:Q9EUM2 it is associated with a helix-turn-helix domain. This suggests that this may be a ligand binding domain.	25.00	25.00	31.00	29.70	24.70	24.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.07	0.71	-4.69	4	723	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	710	16	68	261	3	163.40	73	97.45	CHANGED	MEMTssQRLILoNQYpLMshLDs......tNAp+Y+RLpsIlEpGYuLch+ELs.+EFusLsEpEC+pllDIhEMY+AlpsShssLsD......ppslsp+RloFhGFDu..spEu+hlsYVRFlVssE.GcYpcF.tsEHthNSQsPMhsKYpRML....ssW+sCP...+pYHLSssEIppIlNA	..................................................MEMTNAQRLILSNQYKMMTML.DP...........sNAER......YR.RLQ.TIIERGYGL..QM.R.ELD..RE.F.G.ELpE.ETCRTIIDIMEMYHALHVSWoNLpD..........pQuID...E......RRV......TFLGFDA..ATEARY..LGYVRF.MVNl.....E..G..RY...TH..FD..AGT..H.GFNAQTPMWEKYQRML....sVWHACP.........RQY....H.LSANEINQIINA.........................	0	11	24	46
+4998	PF02542	YgbB		YgbB family	Mian N, Bateman A	anon	COGs	Family	The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis) [1].	25.00	25.00	26.20	26.40	24.80	22.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.78	0.71	-4.40	167	3444	2009-01-15 18:05:59	2003-04-07 12:59:11	11	9	3393	163	843	2387	2171	155.90	48	76.19	CHANGED	hRlGhGaDVHph........................spG......ct.LhLGGVcIPa..p...........p.GLhGH..SD..uDVllHAlsDALLGAs...uhGDIGpaFPso.Dsp.....aKsssSthLLpcshphlpppGa.plsNlDsTl.luppPKluPa.hstM+pslAphLslshspVslKATTsEpLGFsGRtEGIAAhAls..Llhp.t	..........hRlGpGaDVHph..................................sts.cs...lllGGVcIPa..c......................p..GLluH..SD..uDVhlHAlsDALLGAs...uLGDIGchFPDT.Dsp.....aKGA-SttLLccshc.hlpp........p..G..a.pluNlDsTl.IAQtPKhs.......P+.lspM+tslAcsL.sh.........s.h.sp..VsVKATToE+.L.GFsGRtEGIA.u.pAlsLLhc.t...............	0	298	571	724
+4999	PF02325	YGGT		YGGT family	Bashton M, Bateman A	anon	Pfam-B_983 (release 5.2)	Family	This family consists of a repeat found in conserved hypothetical integral membrane proteins.  The function of this region and the proteins which possess it is unknown.	21.70	21.70	21.70	21.80	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.62	0.72	-4.04	170	4945	2009-01-15 18:05:59	2003-04-07 12:59:11	12	4	3567	0	1081	2737	2206	77.70	26	80.00	CHANGED	lphh..lsl.ahhllllps...llSWl........s.....sshs....phlhplT-PlLpPlR.....Rll.P...sl.Gu......l..DhSPllshlllphlphhl.hth	.........................hllplahhllllph...lhSWhss........shp.....sshs.........phlhplo-Pll.t..Pl...R.....Rll..P....sh..Gs.........l..DhS..sllhhllLthlphhlh..h...........................	0	315	665	900
+5000	PF04945	YHS		YHS domain	Bateman A	anon	Bateman A	Domain	This short presumed domain is about 50 amino acid residues long.  It often contains two cysteines that may be functionally important.  This domain is found in copper transporting ATPases, some phenol hydroxylases and in a set of uncharacterised membrane proteins including Swiss:Q9CNI0. This domain is named after three of the most conserved amino acids it contains.  The domain may be metal binding, possibly copper ions. This domain is duplicated in some copper transporting ATPases.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.33	0.72	-4.11	23	1534	2012-10-03 05:12:49	2003-04-07 12:59:11	8	45	1045	41	530	1375	156	45.40	29	10.53	CHANGED	sp-Pssuhpl....sphphcYpG+tYaFsS-sCcttFcp-PEcYhstt	.....................DPVsuhtl.....t..p.ut....h..p.....h.p...YpGp.pY..aFCSppCtppF.ctcPpcYl...........	0	154	311	444
+5001	PF03755	YicC_N	YicC_N-term; 	YicC-like family, N-terminal region 	Finn RD	anon	Pfam-B_3743 (release 7.0)	Family	Family of bacterial proteins. Although poorly characterised, the members of this protein family have been demonstrated to play a role in stationary phase survival [1]. These proteins are  not essential during stationary phase [1].	25.00	25.00	25.10	28.20	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.01	0.71	-4.30	185	2490	2009-09-10 21:41:45	2003-04-07 12:59:11	8	3	2470	0	578	1769	632	155.00	32	53.65	CHANGED	lpSMTGFu+spt......pss.t.............tphshEl+SVNpRaL-lphRLPcthp.slEstlRchlppp.lpRG+V-splphpts..st.sstslp..........l.Npslhpphhpthpp.lppph..th....t.sls....hsp....lLphsuVlp........pp.t-...-t.pth....lhpshcpAlsplhphRpcEGppLtt.	............lpSMTuauRtch.....psp..h................................tphshElRSVNpRaL-hhhRLP.cp.hc.slEsslRctlppp.LsRGKV-splphcts...st..spsplt.........l.NppLscpllpthpp...lptph..st.......spls....hsc......lLc...h.P.GVhs.............sp.t.p-h..-shpt.......lhsulcp...........ALcshhssRppEGptLpt......................	0	207	385	486
+5002	PF03853	YjeF_N		YjeF-related protein N-terminus	TIGRFAMs, Griffiths-Jones SR	anon	TIGRFAMs	Domain	YjeF-N domain is a novel version of the Rossmann fold with a set of  catalytic residues and structural features that are different from the conventional dehydrogenases [1]. YjeF-N domain is fused to  Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and  FLJ21128) [1], where they may be involved in decapping and catalyze  hydrolytic RNA-processing reactions [1].	24.90	24.90	24.90	25.00	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.04	0.71	-4.65	82	3610	2012-10-10 17:06:42	2003-04-07 12:59:11	10	26	3275	37	1227	3081	755	164.50	29	35.13	CHANGED	shhLMEpAupussc.hlpphh......................sptppllllsGsG......NNGGDGlssARhL..hptGhp.Vpl..........hhhtt.t.phssssppthphhpphs.......hphhp.tsttt...........................sclllDAlhGh.................Ghp.tslcs...t.....htpll.....p..tlNps.......psh.llulDlPSGl..sss.oGps...............s.s.......lp.AchTlohttsK.u	............................................h..tLMcpAGtu....ssp.hhtpth.........................................................................spsppl.lllsGs.G.............NNG..........GDGhlsARh..L...t.t...t..G.hp..Vsl......................hh.ht.s.....p.......hspp.....st.......t.sh.p.t..hp.p...h.u.................st..h...h...s.....t.....h............................................................................s-lllDAlhGh....................................G..lp.....tslcs........s.........hspll.............p..tlNpp.....................................sss..llAlDlP.S..Gl.....suc..oGts.........................uss........................lp.AshTlohtshK.s..................................	0	398	764	1032
+5003	PF03739	YjgP_YjgQ		Predicted permease YjgP/YjgQ family	Bateman A	anon	COG0795	Family	Members of this family are predicted integral membrane proteins of unknown function.\	    They are about 350 amino acids long and contain about 6 transmembrane regions. They are predicted to be permeases although there is no verification of this.	27.40	27.40	27.50	28.60	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-5.71	131	5380	2012-10-03 05:18:07	2003-04-07 12:59:11	9	5	2456	0	1233	3656	4737	347.90	20	93.70	CHANGED	RYlhcphlhshlhshhslhhlhhhh.phlphlsph.hpts..ls................hhtllphhh.htlPthlh.hhlP..luhlluslhshupLspssElsulpuuGlShhclhhPhlhhulhlslhshhhsth.lhP...huppphpplhpphhppshtt...........hpsshahptss.................hhlalp..phssssp......hpsl..hlhch...........pp..tshtp..........................................................hl..tAcpuphp.........stthhLpsuphhphstt.....................................................................phphhphpphphphs.hpspphpthttp.......................................................................pphsh.........................tpL...................t.hp.h......pttshs..htphp.hchap+luhPlsslhhslluhs..huhtt..Rtsptts.......hhhulllhhh.aahltthspshutp...shl.ss...hl..usahssl.lhhhlu...hh......lhh+	...............................................................................+Ylh+phhts....hhh.s.hh.hLlsl.h.hh...h.....p......h.l.c....ls...ph...spus......hs....................h.t.h.s..l.t.hhh.hplPphl....hhlPluhhluslhsLup.LspcSElslhpAs.GhShhplhtss..hhhu.lhls.llshhlsta.lsP....hupppt.p......ph...h.s.p.tt.spssht.................th.p..p..u...h..at.p.pss...............................phla.lc....p..l..s.s..stt......................hpsl..hlhpht.......................ps....tpht..s.......................................................................lh..hAcpup.hp......................sphh.hLpsspph....ph..s.st...............................................................................phphpph...pp..h.p..ht...hs....hps..p..tl...s..s.h..t..h.t.....................................................................................................................................................................................................cphsh...........................................tpL............................................................................t..h..tttsps........ssphp..hp.hap+.lshPl.ss.hhhsLluls....h..u..h..ss....Rp.u.phhs............llsull..lh..hh..aahl.tp.hht.s.h.u..tt.....stl..ss................hl...uhhhssh..lhhh..lu..lh.Lh......................................................................................................	0	387	789	1034
+5004	PF02326	YMF19		Plant ATP synthase F0	Bashton M, Bateman A	anon	Pfam-B_984 (release 5.2)	Family	This family corresponds to subunit 8 (YMF19) of the F0 complex of plant and algae mitochondrial F-ATPases (EC:3.6.1.34).	21.80	21.80	21.80	22.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.24	0.72	-3.41	23	331	2012-10-02 21:03:42	2003-04-07 12:59:11	10	3	267	0	25	589	973	79.00	31	61.04	CHANGED	PQLDphTahoQFFWLslh......FhshYl..hlh......pphLPtls+ILKlRpphhpp.h...splppppp...httcshltcs.h..................hshl.pol	...........PQLD..ph..T..YaoQaFWhhlh......hhshYl..hls..........t.hlstIsclLKlRpph.l.ppp.........................................................h....................................................................................................................	0	9	15	18
+5005	PF01514	YscJ_FliF		Secretory protein of YscJ/FliF family	Bateman A	anon	Pfam-B_736 (release 4.0)	Family	This family includes proteins that are related to the YscJ lipoprotein, and the amino terminus of FliF, the flageller M-ring protein.  The members of the YscJ family are thought to be involved in secretion of several proteins.\	    The FliF protein ring is thought to be part of the export apparatus for flageller proteins, based on the similarity to YscJ proteins [2].	23.90	23.90	24.10	24.00	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.24	0.70	-11.00	0.70	-5.17	21	3384	2009-01-15 18:05:59	2003-04-07 12:59:11	12	9	2156	28	653	2296	453	200.40	28	45.09	CHANGED	hpthpth.........hslhhhl..hlhsuspt.......tpLYsuLspp-uNcllshLtptsIsscppssssu....lhVspsphspAhhlLsspGL.P+pshsshtplFspsuLlsoshpEps+hhhAlppELucTlspIcGVhsARVHlsLPcc.sshscsspPsSASVhl+hpsshsls.s.lssI+pLVssSlsuLsh.....-ploVl.sstt.....spsspsh	............................................................hhh..............h....hhlsl..h..lhl.....hhh...s...t.ss..p...........hpsL.as.s..L..spp-..u...s..pllshLppt.sIs.achp...s........s.........us........s........lhV.sts.c.ht.p.....s.+h.h.Lsp.pG.L..P..p...s...s.t.s.uh....plhs..p.p.sh.u.sSphtE..psp....hppAlEtELs+.oI.p.sl.ss..VpsARVH.l........u...hPcp...sha.....s...c....p..p..p...s...s..oA.SVhlp.h.p.s...u.ts...Ls...tp.lsuI...hpLVuuuVsuLs.......psVollDpsu.phls...t.....stt..................................................	0	201	389	515
+5006	PF04650	YSIRK_signal		YSIRK type signal peptide	Bateman A	anon	Pfam-B_3441 (release 7.5)	Motif	Many surface proteins found in Streptococcus, Staphylococcus, and related lineages share apparently homologous signal sequences. A motif resembling [YF]SIRKxxxGxxS[VIA] appears at the start of the transmembrane domain. The GxxS motif appears perfectly conserved, suggesting a specific function and not just homology.  There is a strong correlation between proteins carrying this region at the N-terminus and those carrying the Gram-positive anchor domain with the LPXTG sortase processing site at the C-terminus.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.77	0.72	-6.95	0.72	-4.37	66	6800	2009-01-15 18:05:59	2003-04-07 12:59:11	12	627	727	0	247	4894	0	26.50	41	2.13	CHANGED	tp+pp+YSIRKhs.lGsuSVhlusslhh	........p+pp+aSIRKho.lGsuSVlluohlhh......	1	29	57	149
+5007	PF02295	z-alpha		Adenosine deaminase z-alpha domain	Mian N, Bateman A	anon	Pfam-B_11136 (release 5.2)	Domain	This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric  hindrance [1].  	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.91	0.72	-4.20	8	330	2012-10-04 14:01:12	2003-04-07 12:59:11	12	22	95	39	79	339	3	62.40	29	16.39	CHANGED	stss.cpplLsaLcplG.spssTAhALshplsh.K+-IN+hLYsLp+pGclp+psGsPPlWplssts	....................tp.pphlhphLpphu.tpsspslshshtLs.h..K+-lN+sLYcLp+pupV.h.p..ps.s.p.PPhWhls...t..........	0	14	20	32
+5008	PF01559	Zein		Zein seed storage protein	Bateman A	anon	Pfam-B_181 (release 4.0)	Family	Zeins are seed storage proteins. They are unusually rich in glutamine, proline, alanine, and leucine residues and their sequences show a series of tandem repeats [1].	24.60	24.60	26.10	24.60	21.30	23.80	hmmbuild  --amino -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.11	0.70	-5.12	9	325	2009-01-15 18:05:59	2003-04-07 12:59:11	11	3	7	0	22	337	0	134.90	41	97.79	CHANGED	IIPQCSLAP.uAIIPQFLPPVTSMGFEHPAVQAYRLQQALAASlLQQPIAQLQQQSLAHLTIQTIAsQQ.......QQQQ.FLPALSpLAssNPVAYLQQQLLASNPLALANssAYQQQQQLQQFLPALSQLAMVNPAAYLQQQQLLSSSPLAVuNAsTYLQQQLLQQIVPALo.QLAVANPsAYLQQ..LLPFNQLsVoNSAAYLQQRQQL..lNPLsVANPLVAAFLQQQ..QLLPYNQhSLMNPALShQQPIVGGAIF	.......................................................................................................................................................................................................................................................................................................hp.QlshhN.....suY..QQ....hLP..FsQLss.s..ssuaLpQ.Q......h......s.....ssh......p..h....h................................	0	0	22	22
+5009	PF01754	zf-A20		A20-like zinc finger	SMART	anon	SMART	Family	The A20 Zn-finger of bovine/human Rabex5/rabGEF1 is a Ubiquitin Binding Domain [5-6]. The zinc finger mediates self-association in A20. These fingers also mediate IL-1-induced NF-kappa B activation.	21.60	21.60	22.20	21.60	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-6.89	0.72	-4.35	53	982	2009-09-21 14:31:35	2003-04-07 12:59:11	11	20	182	26	514	896	0	25.10	43	10.59	CHANGED	shhC.psGCGFaGsstspshCS+Ca+	.......hhC.tsuCGFaGsstspshCScCa+...	0	109	204	332
+5010	PF01428	zf-AN1		AN1-like Zinc finger	Bateman A, SMART	anon	SMART	Family	Zinc finger at the C-terminus of An1 Swiss:Q91889, a ubiquitin-like protein in Xenopus laevis. The following pattern describes the zinc finger. C-X2-C-X(9-12)-C-X(1-2)-C-X4-C-X2-H-X5-H-X-C Where X can be any amino acid, and numbers in brackets indicate the number of residues.	23.60	23.60	23.60	23.70	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.21	0.72	-4.08	181	1823	2009-01-15 18:05:59	2003-04-07 12:59:11	11	43	398	8	1124	1782	126	42.70	34	20.23	CHANGED	Csh..Cpptsh..h....shp...Cp.CstpFCtpHRh.-sHsC........sthhptps	.........................Csh..Ccppsh....h....shp.......Cc..CsphFC.t.pH.Rh.s......-sHsC.shshpt..s.......................	0	351	592	859
+5011	PF00096	zf-C2H2		Zinc finger, C2H2 type	Bateman A, Boehm S, Sonnhammer ELL, Gago F	anon	Boehm S	Domain	The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity  site for Sp1 binding to the wt1 promoter [2].	20.80	14.10	20.80	14.10	20.70	14.00	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.01	0.73	-7.19	0.73	-3.30	194	44392	2012-10-03 11:22:52	2003-04-07 12:59:11	21	6603	1241	52	26561	243772	896	23.40	34	6.87	CHANGED	apCp...tCs...csFsppspLppHhpp...H	..............apCp.........tCu........KsF.s.p..p.s..s.L..ppHhch..H..............	0	6055	9206	17573
+5012	PF00105	zf-C4		Zinc finger, C4 type (two domains)	Sonnhammer ELL	anon	Prosite	Domain	In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.	21.10	18.00	21.10	18.90	21.00	17.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.87	0.72	-3.74	26	7638	2009-11-03 19:32:23	2003-04-07 12:59:11	13	91	562	105	3458	7043	2	66.30	47	14.76	CHANGED	phCtVCGD+ASGhHYGlhoCEGCKGFF+Rolppshp..YsCttsps..ChIDKppRspCQhCRh+KClpVGMs+	........................t.hChVC.G...D...c....u..o....G..h.....H.YG.......l.h...............o..CE.......G.........C.....K..............u.FF.....+.........R...........o.l....p...........p.........p.hp...........Y.p.....C....t...t.....s.......p...s.............C................I......s...........+................p.........p....R.....p..........p........Cp.h..CRh.pKClp.s.GMp........................................	0	862	1129	2576
+5013	PF01396	zf-C4_Topoisom		Topoisomerase DNA binding C4 zinc finger	Bateman A	anon	Pfam-B_1854 (release 3.0)	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.19	0.72	-4.45	27	10157	2012-10-03 10:42:43	2003-04-07 12:59:11	14	102	3740	0	1974	7084	1633	39.50	35	11.65	CHANGED	stpCPcCG.upllh+pu+hG...pFlGCoNaPcCcasp.hppp	.................pCP..p..C......G....u.....p.....h.ll......+.p....u.....+hG.........hF.h..uCos..Y.....P....c....C.chsp.h...t................	0	613	1165	1614
+5014	PF02928	zf-C5HC2		C5HC2 zinc finger	Bateman A	anon	[1]	Domain	Predicted zinc finger with eight potential zinc ligand binding residues. This domain is found in Jumonji [1]. This domain may have a DNA binding function.	21.00	21.00	22.10	21.50	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.10	0.72	-3.90	52	591	2009-01-15 18:05:59	2003-04-07 12:59:11	11	55	220	0	364	545	6	54.70	37	4.03	CHANGED	CphC+shsaLStlsCp.sps.schsCLpHhpplC.sC...sssp...........psLhYRash--Lpshl	.........CthC+ssCaLSulsCp.s.ps..s.......pllCLpHs..pcLC...sC...sspc...........ppL.hYRYol--L.shh...........	0	88	162	259
+5015	PF01807	zf-CHC2		CHC2 zinc finger	Bateman A, Griffiths-Jones SR	anon	Pfam-B_755 (release 4.2)	Domain	This domain is principally involved in DNA binding in DNA primases.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.25	0.72	-4.44	19	5345	2012-10-03 10:42:43	2003-04-07 12:59:11	15	58	4422	3	1153	4188	2239	96.10	38	16.85	CHANGED	lspphIspltpphDIV-llupY.VpLKKpGcs.ahuhCPFHsEKTPSFoVsspKpaY+CFGCGsuGssIsFlMchcplsFs-AlccLActhslclshpps	........................................h.spphIpplhs..p...s..s..I.l.-lls...p..h....V.....p....L....+....K....p.....G.p.....s.....a........h.u.h..C..P...F...H...s.....E...K.....T..P...S..Fs..V....s.....s...........p......K.....p....h...aHCF...G...C...G....t.u.G...s.s.lsF......l.hc.h.....-......p.l.......s.F.s..E.AVcpLApphslpls...t..................................	0	413	797	991
+5016	PF05207	zf-CSL		CSL zinc finger	Wood V, Bateman A, Mistry J	anon	Pfam-B_12353 (release 7.7)	Domain	This is a zinc binding motif which contains four cysteine residues which chelate zinc [1].  This domain is often found associated with a Pfam:PF00226 domain.  This domain is named after the conserved motif of the final cysteine.	29.20	29.20	29.20	29.60	28.50	29.10	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.31	0.72	-4.46	63	560	2009-09-14 12:18:22	2003-04-07 12:59:11	8	13	302	5	396	552	5	58.50	38	39.82	CHANGED	--lcl-Dhpa.cp...ppp...h..ahasC..CGDt..Fplotp-......................Lpcs..............-.lspCsoCSLhl+Vlas	....................................-clclEDhpa...-p.......spp.....h.....ahYPC..CGDp..Fploc--.......................................Lcps..........................-plss..CsoCSLhl+Vla....................	0	126	209	321
+5017	PF05180	zf-DNL		DNL zinc finger	Wood V, Bateman A	anon	Pfam-B_9925 (release 7.7)	Domain	The domain is named after a short C-terminal motif of D(N/H)L. This domain is a novel zinc-finger protein essential for protein  import into mitochondria [1].	20.90	20.90	21.20	21.70	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.42	0.72	-4.26	36	372	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	277	1	263	362	4	65.70	43	36.22	CHANGED	h.lsFTC........phCspRSs+phSKpAYp+GsVllpCPuCcN+HLIADpLuhFt.D..pch.....slE-lltpcG-pl	..............................h.lsFTC..........psC.s..pR.Ss.+phSKpAYc+Gs.VllpCsGCpsc.......HlIADpLshFp...-.......tch...........slE-lltt+Gcp........................	0	85	151	222
+5018	PF02701	zf-Dof		Dof domain, zinc finger	Mian N, Bateman A	anon	Pfam-B_1250 (release 5.5)	Family	The Dof domain is a zinc finger DNA-binding domain, that shows resemblance to the Cys2 zinc finger [1]. 	26.60	26.60	27.00	27.10	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.27	0.72	-4.05	12	858	2009-01-15 18:05:59	2003-04-07 12:59:11	10	12	68	0	436	848	5	61.10	65	20.51	CHANGED	pssphltCPRCcSssTKFCYYNNYslsQPRaFCKsCRRYWTcGGoLRNVPVGGGsRKsKpsuo	...........p..pphLpCPR.Cs.S.h.s.TKFCYYNNY....slo....QPRHFCKs..C+RYWTcGGoLRNV...PVGG..GsRKsKpt..t..................	0	71	291	367
+5019	PF04770	ZF-HD_dimer		ZF-HD protein dimerisation region	Kerrison ND	anon	Pfam-B_2002 (release 7.6)	Family	This family of proteins has are plant transcription factors, and have been  named ZF-HD for zinc finger homeodomain proteins, on the basis of  similarity to proteins of known structure [1].  This region is thought to  be involved in the formation of homo and heterodimers, and may form a zinc finger [1].	19.40	19.40	22.20	22.50	18.80	18.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.51	0.72	-3.91	36	349	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	39	0	213	332	0	58.20	56	24.97	CHANGED	sssspY+ECLKNHAAulGGHAlDGCGEFMsu.utp.ss........ssuL+CAACGCHRNFHR+Espsss	................t...s+Y+EChKNHAAulGGa.AlDGCGEFMsu.Gp-...Go.....................suL+CAACGCHRNFHR+Esp..s.............	0	27	141	179
+5020	PF01422	zf-NF-X1		NF-X1 type zinc finger	Bateman A	anon	Bateman A	Family	This domain is presumed to be a zinc binding domain. The following pattern describes the zinc finger. C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C Where X can be any amino acid, and numbers in brackets indicate the number of residues. Two position can be either his or cys. This family includes Swiss:P40798, Swiss:Q12986 and Swiss:P53971. The zinc fingers in Swiss:Q12986 bind to DNA [1].	21.30	21.30	21.50	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.30	0.72	-3.96	21	469	2009-01-15 18:05:59	2003-04-07 12:59:11	12	11	145	0	254	497	0	21.40	56	4.43	CHANGED	CG.....HpCpphCH..GsC.s....C.p	...........CG............HpCpphCHt.GsCtP.....C.p..........	0	57	98	163
+5021	PF00645	zf-PARP		Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region	Bateman A	anon	Prosite	Domain	Poly(ADP-ribose) polymerase is an important regulatory component of the cellular response to DNA damage. The amino-terminal region of Poly(ADP-ribose) polymerase consists of two PARP-type zinc fingers.  This region acts as a DNA nick sensor.	21.10	21.10	21.50	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.07	0.72	-3.74	54	620	2009-09-11 00:32:30	2003-04-07 12:59:11	13	68	222	32	406	653	6	80.80	30	14.72	CHANGED	EYAKSuRusC+...pCp...pcItKsplRluphlpssth..........hthhpWaHhsChhtcthp.............tshsslp..Gacp.....Lp...-DQcc....l+ctlp	...................................EYAKouRu.sCK....tCp....ppI...t.Ksp..l.Rluth....s.ssht.................uth.pWaH..h..sChhppttph.........................tshsplc.Gapp.....Lp...-Dpcplpctl.t................................................	0	154	220	329
+5022	PF00641	zf-RanBP		Zn-finger in Ran binding protein and others	Bateman A	anon	Prosite	Domain	\N	23.80	17.00	23.80	17.00	23.70	16.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.50	0.72	-4.84	24	3729	2012-10-03 10:42:43	2003-04-07 12:59:11	13	208	314	29	2137	3538	147	29.60	34	7.44	CHANGED	+tG.pWpC..ssCs.hpNpspss+ChtCpus+.s	............u.sWpC.......ss..Cs.hhNh.spp..s.p.C...t..Cpss+............	0	545	976	1540
+5023	PF02135	zf-TAZ		TAZ zinc finger	De Guzman R, Mian N, Bateman A	anon	IPR000197	Family	The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1.  The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.	19.00	19.00	19.00	19.10	18.60	18.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.14	0.72	-10.63	0.72	-3.97	22	729	2009-01-15 18:05:59	2003-04-07 12:59:11	11	57	134	16	456	660	8	76.50	38	8.52	CHANGED	hplpchL.hLlHApp..Cps.t...............spCsh..pCtph+pllpHhpsCpttp...hstChts+pllp....Hh+pCpctc.CsVshs	...............................t..lQppl.hLlHApp.....Cpp..................................ssC.s.l....PpCppMK....pllpHh.ppC............p....t...pp...................sut..Cs.s+p..llu............Hh...KpC....p...c......p....c....CsVshs.................	0	164	240	349
+5024	PF02953	zf-Tim10_DDP		Tim10/DDP family zinc finger	Bateman A	anon	Pfam-B_1207 (release 6.4)	Domain	Putative zinc binding domain with four conserved cysteine residues.  This domain is found in the human disease protein Swiss:O60220.  Members of this family such as Tim9 and Tim10 are involved in mitochondrial protein import [1].\	   Members of this family seem to be localised to the mitochondrial intermembrane space [2].	19.80	19.80	20.20	20.10	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.70	0.72	-4.68	113	1455	2009-01-15 18:05:59	2003-04-07 12:59:11	10	16	335	20	1012	1331	11	64.70	25	64.21	CHANGED	.phlttEtphtphpphhs...clscpCacKClsp.......ssupLs....psEpsClspCss+ah-ssttlupphppp	.............................h.tptphpph...t..phhs........pls..ct..CacKC.lss..........hssspLs..........spE.psClsp....Css+ahcssphlspphtp.................	0	311	524	818
+5025	PF02176	zf-TRAF		TRAF-type zinc finger	Mian N, Bateman A	anon	IPR001293	Family	\N	22.80	20.90	22.80	20.90	22.70	20.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.45	0.72	-3.59	10	1745	2012-10-02 00:06:50	2003-04-07 12:59:11	13	81	229	11	1175	1418	42	55.90	26	18.63	CHANGED	Hhps.CPhhslsCsstCst+hl.Rcclp-HlctsCspsclsCpF...GCppphptpsLQcH	......................H.tp.C..h.h...ltC..s.....p...t..s..s.p.p.............l....Rp.....pl.pp..Hh.p............pC.s.p......p............h..p.Cpa..................Cpt..p.h....tpphtpH.............	0	568	732	927
+5026	PF02207	zf-UBR	zf-UBR1; 	Putative zinc finger in N-recognin (UBR box)	SMART	anon	Alignment kindly provided by SMART	Family	This region is found in E3 ubiquitin ligases that recognise N-recognins [1].	21.20	21.20	21.20	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.67	0.72	-4.26	99	1193	2009-09-11 04:39:18	2003-04-07 12:59:11	15	56	293	33	848	1163	4	71.30	30	4.46	CHANGED	phCst.htpt..........pshYpChsCsh........sss....sslChsCashssHp..sHchhhhhsp...tsuhCDCG...ssps.......hp...p....Cph+..p	......................p.hCshshtst..........pshYpC.p..TCsh...............ss.s.........s.slChsC.tts.sHp..sHchphhhos...tshhC..........DCGssph......hp....t.......Cp...t........................	0	316	455	695
+5027	PF03470	zf-XS		XS zinc finger domain	Bateman A	anon	Bateman A	Domain	This domain is a putative nucleic acid binding zinc finger found in proteins that also contain an XS domain.	21.00	21.00	21.50	21.90	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.30	0.72	-3.91	12	126	2009-01-15 18:05:59	2003-04-07 12:59:11	9	13	22	0	79	124	0	41.60	45	7.07	CHANGED	CPaC.scKKps..Yp.hpsLLpHAsGlGtustp...u+cKApHhALA	CPaCssc+..cps..Yp.hp-LLpHAsGl.Gtustp.+.u+c+A.sHhALA........	0	11	47	67
+5028	PF01258	zf-dskA_traR	zf_dskA_traR; 	Prokaryotic dksA/traR C4-type zinc finger	Finn RD, Bateman A	anon	Prosite	Family	\N	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.99	0.72	-4.19	241	5127	2012-10-03 10:42:43	2003-04-07 12:59:11	12	11	2754	13	1228	3101	1711	36.80	38	28.18	CHANGED	sshuh..Cp..pCG-tIsttR.hphh..s.ssthClsC...pppt-p	................paGh....C-..pCGp.IshtR.LcAh..P.ssphClcC.......pphtE..............	0	410	784	1014
+5029	PF04071	zf-like	DUF379; zf_like; 	Cysteine-rich small domain	Kerrison ND, Finn RD	anon	COG2158	Family	Probable metal-binding domain.	19.60	19.60	20.60	21.00	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.70	0.72	-4.28	24	168	2009-09-10 20:56:46	2003-04-07 12:59:11	7	9	158	0	79	154	6	85.40	33	50.46	CHANGED	cphphhh..h...s.pcsCEYYPCH.apsQ...sChaCYCPhYPCtDpph.GcalpspsG.t.tlWuCpsCpllHcs-ssstllcphpphscphp....shc	..........t...aphasscsCcaaPCH..hpsp....NCLFCYCPLYsht-pss.G..p..ahh..sc.sG......lKsCosCtlPHct-s.hshlhpphtphht........pt............................	0	23	57	68
+5030	PF04354	ZipA_C		ZipA, C-terminal FtsZ-binding domain	Mifsud W	anon	COG3115	Domain	This family represents the ZipA C-terminal domain. ZipA is involved in septum formation in bacterial cell division. Its C-terminal domain binds FtsZ, a major component of the bacterial septal ring. The structure of this domain is an alpha-beta fold with three alpha helices and a beta sheet of six antiparallel beta strands. The major loops protruding from the beta sheet surface are thought to form a binding site for FtsZ [1].	20.60	20.60	20.90	20.70	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.44	0.71	-4.67	59	1250	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1235	12	217	840	288	128.60	41	38.95	CHANGED	sppllllp.VhAppspthpGspLlpsl.shGhca.G-MsIFHRHtc......sususVlFSlANhhpPG..sF-.-s.hppFsTsGlshFMpLPs.u.suhpsFchMlpsApplAccL.sG.lLD-pRshhTt........pshcpa+p+l	...........................................................p.ptVIlhp.VsA+p.s.ptlsGphLlsulppsGFhF.G.-.MsI.FHR.H.hs......sGsGssLFSlANMspPG..oF.D.s.....-....hs..-Fo..T.sGlolFMp...lPuhG....-..sh..........pNF+LM.LpoApclA--l.GGsVLDDpRchhTsQpLccYpsp....................	0	42	104	163
+5031	PF00172	Zn_clus		Fungal Zn(2)-Cys(6) binuclear cluster domain	Sonnhammer ELL	anon	Prosite	Domain	\N	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.94	0.72	-4.04	29	13354	2009-09-16 22:05:51	2003-04-07 12:59:11	13	237	239	36	10553	14063	8	39.10	32	5.66	CHANGED	puCppCRp+KlKCct...ppP........CtpChpts..hcCp.hspppppt	................uCtpCR..p....R..Kl..K....C..Dt...............ppP..............................C..sp..Ct.cts......hp..Ct..ht......t...................	0	1813	5198	8893
+5032	PF00882	Zn_dep_PLPC		Zinc dependent phospholipase C	Bateman A	anon	Pfam-B_1401 (release 3.0)	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.45	0.71	-4.59	152	1056	2012-10-01 21:01:47	2003-04-07 12:59:11	13	12	595	25	245	1095	36	178.70	16	56.63	CHANGED	sHhtl.spsht.....hl...h.t.................h.hthsshhhGuhhPDh........h...........................tths+p...................hhh......h.ptshltthspth.t............................hhhhuhhlGhhoHhlsDhhs..H...........................thhttp..hhpHsthEhthphhh..............................................h..httt.thth........h.thltpthtthhtthhht	.......................................................Hhhlspphhp.........hh..t...................ltp.hpth.hG..shhPDh........h.........................th......hhpscp.....................................pth....pphtcah..ttshpphpp...................................................tphppts.ah.LGhhhHahsDhsp.......H.................................................h.phhshs....ttHsthEphh-phh.................................h..........................................th.......................................................................................................................	2	119	194	221
+5033	PF04228	Zn_peptidase		Putative neutral zinc metallopeptidase	Kerrison ND, Finn RD	anon	COG2321	Family	Members of this family have a predicted zinc binding motif characteristic of neutral zinc metallopeptidases (Prosite:PDOC00129).	20.10	20.10	20.10	20.20	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.06	0.70	-5.18	8	1671	2012-10-03 04:41:15	2003-04-07 12:59:11	8	2	1494	0	416	1190	90	272.60	44	93.05	CHANGED	McWcutRpSsNlEDRRupsGGuu.hGGGG........hh.thGGtsGlllllllLlGhhaGlDlosllG..........Gpssuss.ss.Qsstspuss...tpcEtspFssslLAsTEDTWsplFp.ctGppYppPsLVLaSpss+SACGtApSAsGPFYCPuDpKVYLDhoFas-hpp+hGAuGDFAtAYVIAHEVGHHVQNLLGIhsKlcptpp.ssocApANpLSVRlELQADCFAGVWAppsptct.h.LEpGDlEEAhNAApAIGDDTLQ+pupGhVVPDSFTHGTSpQRhpWFcRGapSGcPupCDTF	......................................................................................................................................Mchps..+p.Ss.N..l-Dp.R...ss........G.G.....su................h.hh...u...G..h....h....G.l.h....h.l....l.l.l.l....l.u...h.h.....h....G........l...D........s...s..l.hs...............................G.p.s...st.p.............p...s...s..t....s..h.sss....................p-cssc.F...s..s....s...l...L...u...s...T...E...DsWs.p...hF.p...p..h...G.....p..s..Y.p.p.P..+.....L.V....h..a..p....G...t...s...p........T......u......C.G...s...u..p...S.....s..h....G.......P...F...YC.....P.u..Dp..p...........VYl....D....l.S.F.a.c.-.h..c.s.....+h....G..............A......s.....G..............D...F...A.......QuY.....V..I...AHEVGHHVQ...pLL.GI.s.+.lpph..pp...ph....o..p.s..p..sN..pL..SV..RhELQADCa..AG.V...W....u+ph.......p.......p.......p..........s.......l........L....E....s...G.D.l..EE..A.LsAApA.IGDD..cLQpp.up..GpVV.PDS.FTHGTSpQRhpWFp+Gac.o.G....-..spCsTF..................................................................	0	123	271	358
+5034	PF04298	Zn_peptidase_2		Putative neutral zinc metallopeptidase	Kerrison ND, Finn RD	anon	COG2738	Family	Zinc metallopeptidase zinc binding regions have been predicted in some  family members by a pattern match (Prosite:PS00142).	20.20	20.20	20.50	35.60	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.47	0.70	-4.99	75	1143	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	1121	0	242	727	493	219.40	45	96.58	CHANGED	sshhlll.lsshlluhhAQh+VpSsFpKYScVpspsGhTGA-lA+clLcssGlh.D..VpVcpls.GpLTDHYDPpsKslRLS-sVYsusSlAAluVAAHEsGHAlQatpsYusLplRsslVPlsshuSsluhhlllhGllh........tstsLlhlGIlLFusuVLFpllTLPVEFsAS.pRAlthLpspG..llss.cEhp.uu+cVLsAAAhTYVAAAlsulhpLLhh...lhlhtsp	.............................................................s..hhlhhlhhhl.lshhAQh+VpSsapKYSpV..psssGh..TGt-lAccILcssGlh..DVpVpp.ss..GpLTDHYDPpsKsVpLSpssYpusSlAusuVAAHEsGHAlQct.puYs.Lc.hRsuLVPVsNhGSsl..u...a.hll....hl..Gllh...........hsssllhlGIl.......Lh.u..huVL..F.plVTLPV...EFsAS.pRAhphLpstG..llsp..cE.ht.tA+KVLsAAAhTYVAAuhsulhpLlRl.lllhtt.p.....................	2	113	190	223
+5035	PF03854	zf-P11	ZnF_P11; 	P-11 zinc finger	Griffiths-Jones SR	anon	PRODOM	Family	\N	25.60	25.60	26.20	66.20	25.20	25.50	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.96	0.72	-4.49	3	115	2009-01-15 18:05:59	2003-04-07 12:59:11	9	1	38	1	0	114	0	49.90	61	52.85	CHANGED	GPhNCKSCWFcsKuLVcCsDHYLCL+CLsLLLSVS-RCPICKpPLPTKLR	G.hNCKSCWFts+uLlcCsDHYLCL+CLslhLssSDhCsICtcPLPT+l..	0	0	0	0
+5036	PF03367	zf-ZPR1	ZPR1; 	ZPR1 zinc-finger domain	Mifsud W	anon	Pfam-B_1372 (release 6.6)	Family	The zinc-finger protein ZPR1 is ubiquitous among eukaryotes. It is indeed known to be an essential protein in yeast. In quiescent cells, ZPR1 is localised to the cytoplasm. But in proliferating cells treated with EGF or with other mitogens, ZPR1 accumulates in the nucleolus. ZPR1 interacts with the cytoplasmic domain of the inactive EGF receptor (EGFR) and is thought to inhibit the basal protein tyrosine kinase activity of EGFR. This interaction is disrupted when cells are treated with EGF, though by themselves, inactive EGFRs are not sufficient to sequester ZPR1 to the cytoplasm [1,2,3]. Upon stimulation by EGF, ZPR1 directly binds the eukaryotic translation elongation factor-1alpha (eEF-1alpha) to form ZPR1/eEF-1alpha complexes [1]. These move into the nucleus, localising particularly at the nucleolus. Indeed, the interaction between ZPR1 and eEF-1alpha has been shown to be essential for normal cellular proliferation [1], and ZPR1 is thought to be involved in pre-ribosomal RNA expression [2]. The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-stranded beta helix with a helical hairpin insertion. ZPR1 binds preferentially to GDP-bound eEF1A but does not directly influence the kinetics of nucleotide exchange or GTP hydrolysis [4]. The alignment for this family shows a domain of which there are two copies in ZPR1 proteins. This family also includes several hypothetical archaeal proteins (from both Crenarchaeota and Euryarchaeota), which only contain one copy of the aligned region. This similarity between ZPR1 and archaeal proteins was not previously noted.	20.30	20.30	20.30	20.40	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.00	0.71	-5.08	14	842	2009-01-15 18:05:59	2003-04-07 12:59:11	8	10	422	2	572	806	66	154.90	34	67.74	CHANGED	cssCPsCstpspT+h..hhssIPaF+EVllMSh.C-+CGa+ssElpsuutlpspG.Rhpl+lps.cDLsRcVlKS-ouolpIPELslEI.Ps.sttGplTTlEGlLpcshctLpps....tpcutcspptpphpcalp+lcpl...hpspp.hTlIl-DPhGNSalps	......................p.o.C.sCt.p.s.s.p.T.+h.......hhspI.....PaF+ElllhohpC-pCGa+...ssElpsuGtlp............pGh+hsLc.l...p...s......p.....D....LsRp.l.lK...........S-ouslp............I..P.EL....-lEl.Ps.s...tG...phTTl..EGlLpphh-tLpppt..................ht..........c......s..s...........sp..........ttp+hppFhp..+.....Lcph....................h.p...s...c..h...s...aTlll-DPhGNSalp...........................................................................	0	199	320	463
+5037	PF00791	ZU5		ZU5 domain	SMART	anon	Alignment kindly provided by SMART	Family	Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.07	0.72	-4.35	30	1349	2009-09-12 23:26:40	2003-04-07 12:59:11	15	421	101	19	679	1023	3	99.30	30	7.68	CHANGED	suhpspGhhsstGGpLp.sspoGVSLlIPsGAIspGpphEhYlslsc....cpst.................................hPP..hcpup.oLLSPlVsCGPsGshhhpPVhLplPHCAshs.t..-c...hhlpLKopssp	...................................................................hsphhhsspGGphp..h.p..s..GlpllIPstshs.t.s.p.php...ht....lshhp....c.ss..................................................................................PP....ht.cs.EsL..hS.ll...ph.G.....PsG...h..p.........F...h..p............PVhlplP..Hhushp..t...-p.....lhL+pps..p......................................................................................................................	0	300	340	472
+5038	PF00569	ZZ		Zinc finger, ZZ type	SMART	anon	Alignment kindly provided by SMART	Domain	Zinc finger present in dystrophin, CBP/p300.  ZZ in dystrophin binds calmodulin.  Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.72	0.72	-4.42	10	2746	2012-10-02 13:15:50	2003-04-07 12:59:11	12	308	324	4	1705	2687	25	44.50	31	4.44	CHANGED	s+cpscCNhCppsshlGhRY+sL+s.sYDLCpuCFhoG+su+sH+M	..................h...thpCs..t..C......p...p........s....l..h.....G...h...R.a.+C..t..p..C...........s.....a..DLCpsC....a...t.....p.....t...htt.p....................	0	562	809	1281
+5039	PF04358	DsrC		DsrC like protein	Kerrison ND	anon	COG2920	Family	Family member Swiss:P45573 has been observed to co-purify with  Desulfovibrio vulgaris dissimilatory sulfite reductase [1], and many  members of this family are annotated as the third (gamma) subunit of  dissimilatory sulphite reductase. However, this protein appears to be only loosely associated to the  sulfite reductase, which suggests that DsrC may not be an integral part of the dissimilatory sulphite reductase.  Members of this family are found in organisms such as E. coli and H. influenzae which do not contain  dissimilatory sulphite reductases but can synthesise assimilatory sirohaem  sulphite and nitrite reductases.  It is speculated that DsrC may be  involved in the assembly, folding or stabilisation of sirohaem proteins [2].  The strictly conserved cysteine in the C terminus suggests that DsrC may have a catalytic function in the metabolism of sulphur compounds [3].	24.90	24.90	25.40	38.20	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.35	0.72	-3.81	87	1238	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	1122	8	258	699	173	107.10	55	95.17	CHANGED	tlphsGpplcsDc-GaLhs.hs-Wsc-lAphlApp.E.........sIs.....LT-sHWcVlpalRcaYtcap...hu.P.slRhLsKshutchG.cKus.oca...LYpLFP.tGPAKpAsKlAGLPKPssCl	..............h...apG+pI-TDs-GYLp-..spWoEslAhhlAcp.E.........GIp...Los-HWEVl+FVR-.FYhE.F.s..TS....P..AIRMLVKAhup.KaGp.EKGN.S+Y...LY+LFP.cG.PA.KQATKIAGLPKPsKCl................	0	84	153	208
+5041	PF04252	RNA_Me_trans	DUF431; 	Predicted SAM-dependent RNA methyltransferase	Kerrison ND, Finn RD	anon	COG2428	Family	This family of proteins are predicted to be alpha/beta-knot SAM-dependent RNA methyltransferases [1].	20.10	20.10	20.20	21.90	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.15	0.71	-4.91	3	169	2012-10-01 22:53:19	2003-04-07 12:59:11	8	4	163	0	133	172	0	195.20	42	90.41	CHANGED	PtlVIEHLEEssSEWL...LLEYpplAcphGs+hllTuupPE...............LRasss+luGVss-hccthsLcRu+VILLDLpAsc-LcPEDAocsoYIVVGGILGDHPPRGRTKcLpTuhhsultsR+LGscQhSlDGAl+TApLIAEG.hRLEEIEFEDsPEl+l-c....sS.sElsL+YAlPKlsGKlLLopGLL-LlKK-luYp-EDLu	.....................................................hallEHh-........thu......t......Ws...hLEYtpI..tc...-...s...G...s...c.....l..l..h.os.....sp..................................hh....h..s..h..tph..t..ul..tp......h...p.....p...h..s...h......c..+.u+..VCLLDPtApp-L............s.............P-Du....s.p.........F-hFlFGGIL....G..................Dc.PPR.DRTuELRpp.....Gh.uRRLGshQMTTDTAVRVT+lllcc..phs......l-cI.alDaPEl+hsc.....................pE.uTEM..PFRYV....hs.pp........G.......cPIhPcGMl-LIKcDssps.-...h......................................................................................	0	38	70	108
+5042	PF04359	DUF493		Protein of unknown function (DUF493)	Kerrison ND, Bateman A	anon	COG2921	Domain	This domain is likely to act in a regulatory capacity like Pfam:PF01842 domains. This domain has a remarkable property in that the C-terminal residue of every protein in the family lies up in the alignment. This suggests that the C-terminal residue plays some important functional role (Bateman A pers obs).	21.90	21.90	22.10	27.70	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.83	0.72	-3.61	166	1622	2012-10-02 00:29:19	2003-04-07 12:59:11	9	2	1588	3	338	823	238	83.00	41	87.90	CHANGED	hcshl.-FPsp.ashKllGt....s................sss..hhpt..lhpllpphh.s...sstslph+.sSspGpYhSlol.slpspup-plcslYppLs.shttV+hlL	...............h.ppLl.EFPss.FsaKVhGp..A.....................ts-..ls-p..VlEVlp+Hs..P...s-assps+.sSS+GsYpSVol.olpAos.hEQl-slYc-Lu.p.hchV+hVL....................	0	86	200	280
+5043	PF04205	FMN_bind		FMN-binding domain	Yeats C	anon	Yeats C	Domain	This conserved region includes the FMN-binding site of the NqrC protein [1] as well as the NosR and NirI regulatory proteins.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.82	0.72	-3.82	182	4808	2009-09-11 22:55:10	2003-04-07 12:59:11	9	81	2361	8	1029	3722	716	88.10	25	29.05	CHANGED	Ghsu......sl.plhl.......sh.....ssp.spIpsl...plhp........p......................p...........E.......Tsuhu....t.h......................pphh......pphhspp....................................................s.tp.lDuloGATloSpultpulppulpth	..............................................................................................................................Ghtu..sl.plhVsl....stp..up....lt..ul....plhp.............p...........................................................p..........E.................TsGlu....spht...........................h.spah..........pphhupp..........................................................................................tts..ss..l..DsloGATlTopulhpulppsh.................................	0	408	712	888
+5044	PF04432	FrhB_FdhB_C		Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus	Kerrison ND	anon	DOMO:DM04087;	Domain	Coenzyme F420 hydrogenase (EC:1.12.99.1) reduces the low-potential two-electron acceptor coenzyme F420. This family contains the C termini of F420 hydrogenase and dehydrogenase beta subunits [1], [2].  The N terminus of Methanobacterium formicicum formate dehydrogenase beta chain (EC:1.2.1.2, Swiss:P06130) is also a member of this family [3]. This region is often found in association with the 4Fe-4S binding domain, fer4 (Pfam:PF00037).	21.30	21.30	21.40	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.36	0.71	-4.83	123	800	2009-09-10 23:45:23	2003-04-07 12:59:11	8	53	463	0	371	792	228	167.20	20	41.60	CHANGED	ptshc+lullGtPCplpAl+chpp........t................hhhhlGlhCspshshpsh..phltchhuls.ps.V.t+..................h-hpp....Gc.....ahlph........t.cus.......hhplslcch............t.hhpss.........CphCtDhssph.....ADlosGs...........hGs..........t.Ghoh.....lhlRocpGpcllctsh.ptshl-spshsst..........htKl	.......................................t...hc+lhhlGpPCplpul+ph.pp...t...h...................hhhlGlhCtss.hshpth.pchlpt..h.s.hp.....ps...lhc...................hchcp...............up........hhlph..................p...ssp..............hhphs.hpch.................................t.hhpsu......C.h.t.C.ts.h..ssph.....ADlolGs..................hus..............tGhoh.lllpop+Gpplhptht.pt..hlpht..............thttt.................................................................................................	0	116	255	326
+5045	PF04609	MCR_C		Methyl-coenzyme M reductase operon protein C	Kerrison ND, Finn RD, Mian N	anon	DOMO:DM04514;	Family	Methyl coenzyme M reductase (MCR) catalyses the final step in methanogenesis. MCR is composed of three subunits, alpha (Pfam:PF02249), beta (Pfam:PF02241) and gamma (Pfam:PF02240) [1]. Genes encoding the beta (mcrB) and gamma (mcrG) subunits are separated by two open reading frames coding for two proteins C and D [2]. The function of proteins C and D (this family) is unknown. This family nowalso includes family MtrC_related,	25.00	25.00	29.70	29.00	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.69	0.70	-5.59	18	122	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	65	0	81	118	17	201.70	34	82.52	CHANGED	M........hhapGGVa+csplh-hlEDl....GGallQ+p.ht.-lhh.hhlP.p-hc.lct.sc.hhGplscuPLsGoElAVVu.SLup+HLPHssCDIuEYLR+sGupoNMlGLARGsG..........+plutlsscEpclIpEHDLAVathGNFcsCIhphpttLh+tl-.l.P.lVVsGuP.-h.h..........YluslGRh.tRh+p.p-lttLcphs--lu+llscpRtslscDP..hoPshVh-hlpppl.sl.t.htPhPls.QhsGhRlKlPYDchs-tIcclc	........................................................................................................................+GplsEs..tts-lslVu.S.uR+Hls+ssC-IophLRctGhp..s..sh..lsLstGsG..............tshhslptcEhc.IpcHclAVhphGNhcspIl.Ktphlhc.lc.lP.llVstuP.-h.................................................t...............................................................................t...................................................	0	17	51	68
+5046	PF04607	RelA_SpoT		Region found in RelA / SpoT proteins	Kerrison ND	anon	DOMO:DM04456;	Family	This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologues in plants and in other eubacteria. RelA is a guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase (EC:2.7.6.5) while SpoT is thought to be a bifunctional enzyme catalysing both ppGpp  synthesis and degradation (ppGpp 3'-pyrophosphohydrolase, (EC:3.1.7.2)) [1]. This region is often found in association with HD (Pfam:PF01966), a  metal-dependent phosphohydrolase, TGS (Pfam:PF02824) which is a possible  nucleotide-binding region, and the ACT regulatory domain (Pfam:PF01842).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.55	0.71	-4.08	102	8755	2012-10-02 22:47:23	2003-04-07 12:59:11	12	55	4348	6	1707	5709	2333	115.20	41	20.29	CHANGED	GRhKphaSIhcKhpc..+s.............h...thcclhDlhulRlls..pp.........hp-CYpslsll+....shac.hss.....chKDY.............Iu.pPKtNGYpSlHssl................hG.pshhlElQIRThtMcthAE.GluuHhpYKpsts	.................................................................................................................GRsKclaSIacKM..pc...+p..................h...th.cclhDlhul...R...lls......pp................................lpDC.Yt.sL..u.h.lH.................sh..a..c...s.hss.........................chKDY.................................Iu...tPKs....N..G.YpS..l..HTsl..............................................hGsps..h..slElQI.RThpMcphAEh.GlAAHWtYKps.t.....................................	0	537	1087	1434
+5047	PF04226	Transgly_assoc		Transglycosylase associated protein	Kerrison ND, Finn RD	anon	COG2261	Family	Bacterial protein, predicted to be an integral membrane protein. Some family members have been annotated as transglycosylase associated proteins, but no experimental evidence is provided.  This family was annotated based on the information in Swiss:P76011.	25.20	25.20	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.45	0.72	-3.89	159	4300	2009-09-13 11:40:02	2003-04-07 12:59:11	8	3	2610	0	729	1905	66	48.10	36	57.58	CHANGED	IllGllGAhlGshl..hshhGh....hts.htluuh..lsullGAllLLhlhp.hlpp	......lllGllGAhlGuhL..hs.h.aG.............sluuh.....lsullGAllllhlhphlh..........	0	177	395	574
+5048	PF04264	YceI		YceI-like domain	Kerrison ND, Finn RD, Bateman A	anon	COG2353	Domain	E. coli YceI is a base-induced periplasmic protein [1]. The recent structure of a member of this family shows that it binds to polyisoprenoid [2]. The structure consists of an extended, eight-stranded, antiparallel beta-barrel that resembles the lipocalin fold.	20.50	20.50	21.00	21.00	20.30	18.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.38	0.71	-4.28	135	3875	2009-01-15 18:05:59	2003-04-07 12:59:11	8	16	2238	16	1127	2995	1071	164.90	25	82.66	CHANGED	sa....pl..............Ds..spoplsFpspc.....h.shsph.......G.pFs.p..hs....G....pl......sshsssth..shslchs..Sl..ss.....t....sthc..pc.lpst......paFcsppaPphsFpus.php.........h................ttt..hphp..GsLTl+GhT+s.lshss...plp.t.....................................................................ts.ps...............hshsup.spls.RscFGlshsthh.................luccV.plplplphp	................................................................................aplDs..sHoplsFphpH............h.shohh......GpFp.p....hs........G..slp.............s.ps..ssspl.........sloIsss...Slsoss......................spRD....pH.L+us.............DFhs.s..s..+aP..p.hoFpoo..plp......................t................pt..spls.....GsLTl+..GlT+s..l.slcs......phh.s................................................................................tu.ps............t.hsGhpus...sp...lp.RpDFGlshshsh.................luccV.plplplph.h...................................................................	0	378	777	993
+5049	PF04431	Pec_lyase_N	pec_lyase_N; 	Pectate lyase, N terminus	Kerrison ND	anon	DOMO:DM04067;	Family	This region is found N terminal to the pectate lyase domain (Pfam:PF00544) in some plant pectate lyase enzymes.	20.70	20.70	20.70	22.00	18.50	20.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.76	0.72	-3.88	15	105	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	30	0	39	93	0	50.40	37	14.34	CHANGED	sIu.EaDEYWpcRu--A+ptshpAYcPcP.sVTs+FNpcVtcuhp..........................ssNsTRRsL	......ls...-chWtp+tc.A+ptshtAYhsDPhslTscFNtcVhcuhp........................................................sRRt......................	0	4	22	30
+5050	PF05223	MecA_N		NTF2-like N-terminal transpeptidase domain	Bateman A	anon	Bateman A	Domain	The structure of this domain from MecA is known [1] Swiss:Q53707 and is found to be similar to that found in NTF2 Pfam:PF02136. This domain seems unlikely to have an enzymatic function, and its role remains unknown.	21.80	21.80	21.80	21.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.52	0.71	-4.03	17	954	2012-10-03 02:27:23	2003-04-07 12:59:11	6	6	730	10	155	737	7	115.00	23	18.53	CHANGED	sssppphppFlsAhsct-hsphhshsspss.........cht-thpslasulpscslcl.........tshpspcsscsphslsachphpsshuch...hshshphphscp-sp.Wp.lcWpsuhlaPphpcsp	.............................................t.pscpshppalsulsc..pcasphhp..ssp.u....p...t.sp.-hs-+hpplYsul..t.sc.slpl....................pphph.p..cs.s.c..sp.tplsaphphcT.shGpl.......................hshsh.phsh......s+....cc....s.....p...W+..lcWssuhIaPshpcsp.....................................	0	55	117	141
+5051	PF05224	NDT80_PhoG		NDT80 / PhoG like DNA-binding  family	Wood V, Bateman A, Glass NL, Moxon SJ	anon	Wood V	Family	This family includes the DNA-binding region of NDT80 [1] as well as PhoG and its homologues. The family contains Swiss:Q05534 or VIB-1. VIB-1 is thought to be a regulator of conidiation in Neurospora crassa and shares a region of similarity to PHOG, a possible phosphate nonrepressible acid phosphatase in Aspergillus nidulans. It has been found that vib-1 is not the structural gene for nonrepressible acid phosphatase, but rather may regulate nonrepressible acid phosphatase activity [2].	19.40	19.40	19.70	19.90	16.80	19.30	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.42	0.71	-4.29	16	421	2012-10-03 00:25:27	2003-04-07 12:59:11	7	11	202	16	306	408	0	168.80	30	24.03	CHANGED	palsY+RNaFplssshsh.t...sphhptshh..........................tsspphplphFtlclpAhcs.s.....spsIpLlQ.........tospccKs.thsPshsslhst..P...h.h.tsp.hs..t...................................splsphspacRLQFppuTssNt+ppt.....QpaFpLpVpLhs...............................sptsssphlhltphposslIVRGRS....Pusapsp	...........................................................asC.++NaFQlosph..s..h.....sphlp.......................................................sstshhslptFtlplpuhcstt........spslplhQ...............................o.pccp.t...hpPshh.sl....s..................................................................................................................................phsp.hohpRLpFp...puTANN.tR++u...........QpaFhLhVpLhA.....................................t.t.sp.s..phhhlutthSt.lIVRups....Pupaps.p...................................................	1	70	146	243
+5052	PF05225	HTH_psq		helix-turn-helix, Psq domain	Lehmann M, Bateman A	anon	Lehmann M	Domain	This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster [1]. In pipsqueak this domain binds to GAGA sequence [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-8.10	0.72	-4.41	27	1317	2012-10-04 14:01:12	2003-04-07 12:59:11	11	67	254	1	1002	1636	41	43.90	28	10.93	CHANGED	sp-pltpAlpslp.....sGt.hSlp+AuphaGlPpSTL..cthctthshpp	................ptplttAl.pslp...........sGp.hS.l.p..cAAphYslPpoTLh.cthpth.....t..............	0	324	585	881
+5053	PF05226	CHASE2		CHASE2 domain	Ulrich L, Zhulin I	anon	Ulrich L, Zhulin I	Domain	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE2 domains are not known at this time [1].	22.00	22.00	22.00	22.70	21.20	21.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.31	0.70	-5.19	160	950	2009-01-15 18:05:59	2003-04-07 12:59:11	6	44	512	0	409	1005	1318	318.30	20	45.69	CHANGED	lslshhhlhhhhhhtts..............hp.....h....-hth.....aDhhhphp.....s...............sc..llIVsID-p.............Sl...........t......up....WP.WsRshhApLl.cpL.............tpt.tspsluhDl..lF.scP.s............................................sDptLupul..tps...ll...ls.h..............................................htttppts..sht.................................................................................................................................................stlttt..stshGhh.shhh..Ds.DG.....llR....+h.l...........hss.t.hhs....ululphh..............thhhsspshtht...t......................................................t...t..................hhlsa........tus....tt......sh.....plSh..t-l....L.....s..uphs.......................shl....cs.+lVLlGs.o....As.ult......DhhsTPh............t..................hsGVElcAshlsslLs....................sp.hlh.hsshs.hhhhlhhshhhulhh	...............................................................................................................................hhh....hhhhh.h.hhhhh.h.......................hpt....h.....-hhh.....aDhhhphp.......................s..s..s.....sp.lllVsID-p...........................ol.................p........phGp..............WP.asR....s....hhApllppL.............tpt...tsp..sluhDl..hh..sps..p........................................................................................sDptLspsl...p..p..s..........ls...lshh......................ht.tt..ttt....h........................................................................................................................................................s.ltt......ssthGhh..sh.h......Ds..DG.......hlR.....ph.l..........................h.t..ss..p..hhs...........ululthh.....hhhhttp.s.hhh.t.t.t.......................................................................................hs...............s....th..p.......................hhlsa..........tus..............tt................sh.........plSh..t-l...L...........p.....splss................................................shl...cs+lVll...Gs..o......As..uht.........D.hhsTPh.........ts............................hsGVplpAphlsslls.........................tp...hl..h.....h...s..t.h..h..t...h..h.hh.h..h.hshhhhh..h..................................................................	0	126	275	353
+5054	PF05227	CHASE3		CHASE3 domain	Ulrich L, Zhulin I	anon	Ulrich L, Zhulin I	Domain	CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE3 domains are not known at this time [1].	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.54	0.71	-4.49	180	1210	2012-10-02 01:04:29	2003-04-07 12:59:11	8	127	733	1	487	1312	72	135.90	19	20.96	CHANGED	ssphlp+ohpllsph...pplhsthh-tEoG.RGYLLTucppa.LpPYpputsplpptlscLp..phs..s......-sP...tQppc....lpplpthhppth.shhcph...lshpcp.....t..shp...sshphltsspG+phhD.....plRphhs..ph.......tspE........ppllppRptp	..........................................t....lp+shplhsphpplht....tlhshEouhRGallo.s..c.p.s.....a...L.psYppu.t..t.p...hppplspLp..pL..s..t......csP........pQ.ppc....l.p.plpthhp...phh..p.hpth...lshtps..........t.t.p.....sshph..l.p.....s.....s.t.u+.thh-........plRphlsph.......psp.E.......pphhttRt..t...............................................................	0	132	288	404
+5055	PF05228	CHASE4		CHASE4 domain	Ulrich L, Zhulin I	anon	Ulrich L, Zhulin I	Domain	CHASE4. This is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in prokaryotes. Specifically, CHASE4 domains are found in histidine kinases in Archaea and in predicted diguanylate cyclases/phosphodiesterases in Bacteria. Environmental factors that are recognized by CHASE4 domains are not known at this time [1].	20.80	20.80	20.80	21.30	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.50	0.71	-4.65	95	529	2009-01-15 18:05:59	2003-04-07 12:59:11	8	79	398	0	207	499	16	160.10	17	23.09	CHANGED	ppslppphpplpphspDaAsWD-sYpalps..pst.t....alpsNls.sphh..pshpl-hhhllstsGphl.a..tpshshpsst..h.hst....................sltphlsphp.h....................ttttpsshsGllhhsssPhlluupsIhssssps.....sspGsLlhsRhlcsshlspl.pphshhslplth..s	.................t..hlp.phpphtphhtDaAhWD-shp..alts......tst..s.............ahpsNls..sphh..pshth-hlh.lh-spuphl.a..t.pst.sh.p.pstt...p.lst....................shpp.hlpphpth...............................sptppshsshhh...hs.st......s.hl.lusss.lpssssps......sstuh.Ll.hs+hlss..phlppl.pphshhslph....st...............................	0	64	129	167
+5056	PF05229	SCPU		Spore Coat Protein U domain	Yeats C	anon	Yeats C	Domain	This domain is found in a bacterial family of spore coat proteins [1], as well as a family of secreted pili proteins involved in motility and biofilm formation ([2]). This family is distantly related to fimbrial proteins.	22.40	22.40	22.40	22.50	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.07	0.71	-4.09	127	1343	2012-10-02 17:35:21	2003-04-07 12:59:11	10	3	332	0	336	1103	36	142.70	23	81.23	CHANGED	sssshsls..sslsssC...slsus.............slsFG..............ssssssssssss.usl...slsC....o......sssshslslssGtssssss............Rphts..uss......hlsYpLYpDuupoph..Wusssssshsss.................sussp....sls...lYGcl.............ssssss.uG....sYsDTlslT	..........................h...shsss...hslhssC....slsus.......................slsFG..............ss.s...s..s.ss.s..s.ss.s...usl....slp.C..........o.........sssshslslssGtssssss............Rphts.....suss......hls.YpL.Yp....-u.up..o.p.h........as.ssssts.sssst..................sussp............sls...lY.upls.....spsss...s..sG........oYsDTlsl....................................................	1	48	107	209
+5057	PF05230	MASE2		MASE2 domain	Galperin M	anon	Galperin M	Domain	Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins.	25.00	25.00	25.00	26.60	23.70	24.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.10	0.72	-4.01	21	590	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	566	0	64	308	10	89.60	59	24.31	CHANGED	+RhYhsRhlGhslshhsluuslhstshsthlWlLLlhtuhlWPHlAaphApR..uppPhcsEptNLhlDuhhGGhWluhMtFssLPolslLsM	.......RRlRLPRAVGLuGMF.LPIAosL..VopPssG..WWWLlLVGW..A.FVWPHLAWQlAuR...AlDPLp..pEIY.NLKsDAlLuGMWlulMGVNsLPSsAhLMh..........	0	9	19	45
+5058	PF05231	MASE1		MASE1	Galperin M	anon	Galperin M	Domain	Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This entry also includes members of the 8 transmembrane UhpB type (8TMR-UT) domain family [2].	29.50	29.50	29.50	29.60	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.95	0.70	-5.40	33	2684	2009-01-15 18:05:59	2003-04-07 12:59:11	9	142	1051	0	372	1651	78	274.00	22	40.20	CHANGED	hhlhhhhhhhlshhhsht.shshssssthslW.hPsGltluhhlhhshpthPsll......lushlhp........hhtthshhhshshshsssltshhushllchhhttttthpph.........................hhhh.sshhsshhsAssshshhhhhshhshs.hstshhhahlushsGsLllsPhshlhhphhhpphth........phh.p..ht.h.hh.hhhhhhhlhhhhshhh.hhh.s.........t...............hlhhssllasAhRaGhpGusl.hhhlhusllhhhththst.hsh..t......h.lp........hal..uhtshssl...hlushlpcpc	......................................h.hl.hhhlhhlh.h.hh..h..h....p.ht.h.h...s..s.........hs..l..a..hPhulh.l.u.hhh...h....h....s....h.t..h.hPslh..............huhhltp.............h..hht....h....s.....h...h.t..s....h......s......hh.....h.h...th...l.....s.l..ls.s....sll..Rhh.h..p..p.s.hshh.......................h.hh.h....hhh..hhhsshshhh.....h..h...h..p......h..s.h...s........h..s.ht..h...h.h.shlup..hs.GsLhh.sP.ls..h.h...h...h...c...h..l.h..p.....p.hh........................................h.h.p..........h.p..p..thh.hhlhhhsl.s.hh...h......h...h...h....s...p...........phhh.................hlhl.....lhah..A...h+hGh..tts..hl.............h.ls.slhh.hhshh..h..st...s.h....................................h..h.................hL...hh.ph...hs...sh....hushhpc..................................................	0	81	199	290
+5059	PF05232	BTP		Bacterial Transmembrane Pair family	Yeats C	anon	Yeats C	Family	This family represents a conserved pair of transmembrane helices. It appears to be found as two tandem repeats in a family of hypothetical proteins.	25.60	25.60	33.50	26.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.30	0.72	-4.23	181	1557	2009-09-10 14:54:21	2003-04-07 12:59:11	7	2	633	0	358	1134	42	67.90	31	89.83	CHANGED	+ohtpRlhHAlhFEhshlhlslPlhAahhshulhpshllsluhshhhhlasalaNhhaD+lhs..h.tsp	.......+ohtpRlhHAlsFEshhlhlssPlhAahhshol........hpsh..sLslshslhhhsashlaNhhaD+lhs.t...hhh....	0	55	137	243
+5060	PF05233	PHB_acc		PHB accumulation regulatory domain	Yeats C	anon	Yeats C	Domain	The proteins this domain is found in are typically  involved in regulating polymer accumulation in bacteria, particularly poly-beta-hydroxybutyrate (PHB) [1]. The  N-terminal region is likely to be the DNA-binding domain (Pfam:PF07879) while this domain probably binds PHB (personal obs:C Yeats).	21.40	21.40	21.60	26.40	19.70	20.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.99	0.72	-4.22	72	555	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	403	0	227	497	146	40.90	38	29.37	CHANGED	hssshLpQlIphYGsshQuhhssYLEpShphFtctQpphpc	....hssshLsQlIphYGssMQGhMssYLEpShphFhchQpphpp.........	0	48	136	179
+5061	PF05234	UAF_Rrn10	UAF_rrn5; 	UAF complex subunit Rrn10	Wood V, Bateman A	anon	Wood V	Family	The protein Rrn10 has been identified as a component of the Upstream Activating Factor (UAF), an RNA polymerase I (pol I) specific transcription stimulatory factor [1]	20.80	20.80	20.90	21.10	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.44	0.71	-4.08	2	57	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	56	0	37	47	0	105.20	36	57.86	CHANGED	Ms.N..sh.sh.Nllpt.GphshpAc-llt...D.uVPIP....cEl......D...........PDl.l+slp.aATphhLsph.+.hpshDEouLlsLGhLlpcWhcshlTsh.pE.tcp	..............................................................................................l.lPh..hp.h...............sphlP..D.D.L+slHYY.Ao.ph....s...L...s....+.....h.........chh..p...uhDETuLIsLGlLlEcWsc-hlst........t.tt................	0	4	14	29
+5062	PF05235	CHAD		CHAD domain	Aravind L	anon	Aravind L	Domain	The CHAD domain is an alpha-helical domain functionally associated with the Pfam:PF01928 domains. It has conserved histidines that may chelate metals [1].	22.70	22.70	23.10	23.50	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-12.01	0.70	-4.78	186	1090	2009-01-15 18:05:59	2003-04-07 12:59:11	9	11	934	2	406	1065	129	229.00	20	53.54	CHANGED	pt.hhtpplp......phhtp..pssl.tps.........-s..EslHphRVulRRLRohlpha.ps.hh.....pthtthp.pcl+tluptLGssRDh-Vhh........tpht..............sthttt....................................................................shttlhptlppp+..pps....tpphtttLputchpphltpl....pp.hl.tt........................................................................................t...htphssptlp....cthc+ltcthpp.t................................................p..sp.p.h.HclRhtsK+LRYshEhht....sh.............sttt..hp....phhcpl+plQ-hLGphpDhsl.ttph.lpph	..........................................................h..hhtpthtphhtt...pttl..pps.........ss....-ulHphRVuhRRLRohLpha...ps.hh......s...tt...tss....tlppcL+hLuphL.......G.hRDh-Vhh......ppht...............htth...............................................................................................shpt.lhpthppp.p.......pt..s....tp.p....h..h...p..t..L...p....o..tca..tp.Llh.sl....pt....hl..s.t..................................................................................................................httshpphsspplc.....+thccl.h.ct.httht...............................................t..............p..sp.t.hHplRhtsK+lRYshEhht.......h..........................................tt......hp...........phhpthctlQshLGphpDhssttthl...h.........................................................................	0	122	261	346
+5063	PF05236	TAF4		Transcription initiation factor TFIID component TAF4 family	Wood V	anon	Wood V	Family	This region of similarity is found in Transcription initiation factor TFIID component TAF4 [1].	24.10	24.10	24.60	24.10	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.79	0.70	-5.11	26	410	2009-01-15 18:05:59	2003-04-07 12:59:11	9	8	239	2	271	367	0	237.20	28	39.18	CHANGED	lNDVhusAGVsLpEEEthLhus.............ophhtshscpsccps......FLp.ttLtphlpcl.................................u..pcps...........hphss-lhpLlSpAscphLpsllpKhhllScHRpcuhK................................t.phthpS-VptpL+tls.hpKp-c-R+tp....cctthhL............Ec.pp....tcstt.s+t-s-chppRsANsTAthtlG.....s+KKaphhsusst..............Spss.....sht.tsstp.ssh......ptp.......hRtt.s..................Ish+DlLhsLEp-R.hs.p......phlhKuYt	....................................................................................lsDlhshuGVslpEEpt.lhts.................o..phhtp..hpp.p...pc.ps.....................F...L..s..Lpp+l.h.cl..............................................s...pcps..............lpphps-.llshlS......tAsppRLpsllcchhhluppRhps.h+.....................................................................sstp.ht..ssD.l+t.pL+hhpp...h-ph-cp....+..+pp......p.-p-.......hh...h+t....u.c..sp.........................stt.....-D..s-p.ph.Kp+sK.c....h.....ppt-.......tp.h.p.p+.s.ANhTAhtAlG............s+K..K...hph.sss.s...........................................stst...........s....s.tst.t..t.............................hc.t.p.....................................................lsl+DllhshEp-tth..p.......hh.....h.................................................................................................................	0	79	127	203
+5064	PF05237	MoeZ_MoeB		MoeZ/MoeB domain	Cortese M, Bateman A	anon	Cortese M	Domain	This putative domain is found in the MoeZ protein and the MoeB protein. The domain has two CXXC motifs that are only partly conserved.	26.90	26.90	26.90	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.74	0.72	-4.39	41	4751	2009-01-15 18:05:59	2003-04-07 12:59:11	8	17	3320	13	1252	3468	1698	83.20	33	27.48	CHANGED	spsPCYRClaPp....st.sssCspu..GVlGslsGhlGslQAhEAlKllsGh..ucslsu...pLLhaDuhsh.cacpl+lp.+cssCssCGsps	..........................t.tsPCYRCLa.sp............stss.h.o.C.s.pu...G..V........luPllGl.lGolQAhEAl.KlL.s....Gh.........ups.h.sG...................+Llha....D.....uhs....h..p.......a+p.l.p.lp...+s.s..sC.s..sCGt..t................................	0	397	765	1050
+5065	PF05238	CENP-N	CHL4;	Kinetochore protein CHL4 like	Wood V	anon	Wood V	Family	CHL4 is a protein involved in chromosome segregation [1]. It is a component of the central kinetochore which mediates the attachment of the centromere to the mitotic spindle [2]. CENP-N is one of the components that assembles onto the CENP-A-nucleosome-associated (NAC) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [4].	25.00	25.00	32.30	25.50	20.10	24.20	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.07	0.70	-5.42	29	193	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	158	0	124	186	0	374.10	25	94.03	CHANGED	s.ss.slh+.hLs+Ls+ssLlsLshpWhppps.................................t.h..tt.lpplpp......hppLpptpsp........KRpll-+IlptsWppGlsLhQlA.lDhth.lh-+Psuh.pWsshplp..................tcsspslsphcsspFlspLppplpslhcsahhl...sRcssLPllhlRIhlhs.s..p.......................ts.psthsop+shYlsasssoPalapSh..sss.h.t...........................+llhpuls+ALotsppphtl...pssphss+s.LpuLhslpG.su....Rps..suhGuao.aA-ssh.........................-.sPL.ssh.pp....tp.................psppp.sppsspppp...........................+pcphspt+Fusospsh............l-phph+l.s..sup.s.t................................................hppspppsplplphsGsclhuGl+cLs......ctGllDspchPuWhT....G..Ecusosuhl+cG	.....................................................s.ss.hlh+.tlh+lshspLhslhhtW...pp.......................................................ppLpphphp...........Kcpllp+llphs.ccu..lolhQlA.lDhha.h.p.+spph.h.....Wsshph.................................tpss.t.sl...sthc.ppFhpshppplp..hh+shhhh...hRctp..shlhlRIhh..............................tsthst.sph+shYlsa..spoPa.lahSh...sp....................................chhh.hlspALohsppphpl....thsLss+s.LcsLhslhh..t....tpp..tutusao.at-ts.h..................................c..sL.p......t..........................................ptt.h..ppp..tpc..........................................+hpphsptpFGssspst...............................................lchhp.h+lps.h.psp.sts..........................................................................st.ppp..phhlpFsGsclhtul+pLs.......................tGlhDs..hsshhTs..ccuhs.hhlcpt........................	0	22	49	90
+5066	PF05239	PRC		PRC-barrel domain	Aravind L	anon	Aravind L	Domain	The PRC-barrel is an all beta barrel domain found in photosystem reaction centre subunit H of the purple bacteria and RNA metabolism proteins of the RimM group. PRC-barrels are approximately 80 residues long, and found widely represented in bacteria, archaea and plants.  This domain is also present at the carboxyl terminus of the pan-bacterial protein RimM, which is involved in ribosomal maturation and processing of 16S rRNA. A family of small proteins conserved in all known euryarchaea are composed entirely of a single stand-alone copy of the domain [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.33	0.72	-4.11	114	6817	2012-10-02 14:14:57	2003-04-07 12:59:11	11	26	3995	121	1960	4958	1373	76.30	21	44.59	CHANGED	.p.hhhsclhGhpVhsps.G...cplGpl..p-lhl-ht.ssclhhlhlshst...............cphhlPhp......thchtpctlhlpshptth	.........................................hhhp-lhGhp..V.hsts..G...................pp...l..G..p.l...p-l.......l....css....u.....s.....c...lhs.......l..t.h.s.t.t.........................................cchl.lPah.............h.pl.cls.s.ctl.hlp......h...................................................	0	622	1275	1636
+5067	PF05240	APOBEC_C		APOBEC-like C-terminal domain	Yeats C	anon	Pfam-B01590	Domain	This domain is found at the C-termini of the Apolipoprotein B mRNA editing enzyme.	23.50	23.50	23.90	24.30	22.80	23.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.01	0.72	-4.56	45	86	2012-10-02 00:10:39	2003-04-07 12:59:11	9	5	33	4	13	662	0	54.00	44	23.25	CHANGED	cspapcGL+pLppuG....splplMsap-FpaCWcsFVcpp.............tps.FpPWcpLpc...p.phLp	......s.apcuLphLppu.G....AplsIMsYs...EFpaCWcsFV-pp.............spP..Fp.PWcsLc-...pSptL.p.................	0	7	8	9
+5068	PF05241	EBP		Emopamil binding protein 	Moxon SJ	anon	Pfam-B_7320 (release 7.7)	Family	Emopamil binding protein (EBP) is as a gene that encodes a non-glycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains, including the sterol acceptor site and the catalytic centre, which show Delta8-Delta7 sterol isomerase activity. Human sterol isomerase, a homologue of mouse EBP, is suggested not only to play a role in cholesterol biosynthesis, but also to affect lipoprotein internalisation. In humans, mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities [1].	31.00	31.00	31.20	31.30	30.80	30.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.48	0.71	-5.29	46	404	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	197	0	278	388	0	182.60	27	79.73	CHANGED	llshhhsssssllssshhls......thh..phstsc+hshhWashsu.hlHhhhEGhFlhpptphss......................................spshh..........................upLWKEYupuDoRYhss.....DshllslEslTsllhGPLuhhlshtlhpp...................cshRahLQlllshupLYGshlYassphhcuh........shshsp.sp.hYaWhYalhhNslWlllPuhllhpohppls..tAh.sth.....pps	.....................................................................h.....h.h.hhlh.hshhhs........hh.......ths.t..hc+hhhhWashs.................u.hl....HhhhE.G.Flh.phh.h.hs............................................................spshh...........................upLW...+...EY.u.pu...DuRYhss........DshllshEhl.Tsh..lhGPluhhhsahlhpp..................................c.shp.a.hl.plh.lu.l....u..plY.G.....shhYas..sphhsu..................s.shsp.s.p.hY.hW........hYhl.h..hNs.lWlllPhhllhpuhtplstuht.....t............................................	0	68	140	213
+5069	PF05242	GLYCAM-1		Glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1)	Moxon SJ	anon	Pfam-B_7429 (release 7.7)	Family	This family consists of the lactophorin precursors proteose peptone component 3 (PP3) and glycosylation-dependent cell adhesion molecule 1 (GlyCAM-1). GlyCAM-1 functions as a ligand for L-selectin, a  saccharide-binding protein on the surface of circulating leukocytes, and mediates the trafficking of blood-born lymphocytes into secondary lymph  nodes. In this context, sulphatation of the carbohydrates of GlyCAM-1 has  been shown to be a critical structural requirement to be recognised by  L-selectin. GlyCAM-1 is also expressed in pregnant and lactating mammary glands of mouse and in an unknown site in the lung, in the bovine uterus  and rat cochlea [1].	25.00	25.00	36.40	36.40	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.74	0.71	-4.24	4	14	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	11	0	4	22	0	122.40	48	88.94	CHANGED	hLstsKDElahcoQPTDA..uAQhh....hSpcpsSScDLSKEPSI.RE-LlSKDsVVIcSs+.PQNQpsp........cuLRsuooQpEETTc.ssuuAoToEGKLscLoppl.KpLtpslcthlshlcslhssASclVKP	........LscscDEhHhcoQPTDA..uAQhh....hSc-plSscDLSKEsSI.+EELlSK-sVVIcSs+.spsQpsp........cslRsus.Q.EETTc.ssp....uAoToEGKLscLuppl.+pLtpshcthhshlcslhssAscls+P...	0	0	0	0
+5071	PF05244	Brucella_OMP2		Brucella outer membrane protein 2	Moxon SJ	anon	Pfam-B_7448 (release 7.7)	Family	This family consists of several outer membrane proteins (2a and 2b) from brucella bacteria. Brucellae are Gram-negative, facultative intracellular bacteria that can infect many species of animals and man [1].	19.20	19.20	19.40	21.90	18.30	19.10	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.70	0.70	-5.21	2	23	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	16	0	0	20	0	179.50	87	61.52	CHANGED	MRSLQlEGsLhtu..LpTTPDSPIAAPLTVVLVRRRCGRICALQP.RE.VGDVDVATNLsSPFFDDRVIGNNTSDRTPAASIhQAANNVRHVsVDhV.....lsssVhATLFESDHSREAVSAuEGVtDLAGAVGASRDHVIVDDIsEVTGEGMEFtFlDTNhpTTchDIpcLp.GAuA........YAtI.....p.............................sIslhstlsVlAhh	MRSLQlEGsLhtu..LpTTPDSPIAAPLsVVLlRRpsGRICALQPNRELVGDVDVATNLGSPFFDDRVIGNNTSDRTPAASILQAANNVRHVAVDVVVGRASVTTVVVATLFESDHSREAVSASEGVRDLAGAVGASRDHVIVDDIAEVTGEGMEFRFIDTNAQTTELDIRELHDGAAA.GFITIFTIYARIVRSIVEAQFGEGLEGAEFGFRTGGNAECETSALVPAIAVGTGVNVIAAL......	0	0	0	0
+5073	PF05246	DUF735		Protein of unknown function (DUF735)	Moxon SJ	anon	Pfam-B_7611 (release 7.7)	Family	This family consists of several uncharacterised Borrelia burgdorferi (Lyme disease spirochete) proteins of unknown function.	23.40	23.40	24.60	24.60	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.31	0.71	-4.57	2	138	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	28	0	10	101	0	180.50	68	99.27	CHANGED	hcIPphhcNTpIcKFIpsEh-YtptlLpELKpL.pNF.oINVhpsIpS+YIAlhh.plhshFahKpph.pslssslsulIFAl+pIGTDESFhllFKsFLpsslEVoosE..sG.I.IpLhGsIKoshph.Iu..sKptp+LKKIhh+.....aAu.KKALs.N.hPKsYcpSlYtFIKhlIPIGRllK........IpsTcspph.Thsp	.....MKIPNhhcNTEIcKFIhTEhEYAQtLLNELKpLNSNFlSINVhENIKSRYIAIWISQVLSIFYAKTQTLQSITSNINSVIFALRHIGTDESFRLIFKAFLNVDI-VT...TPE..AGVIDISLKGsIKTNFTTFISP..STKKGKR....LKKIllREKK.GYAASKKALVFNSLPKGYDHSIYAFIKtIIPIGRVLK........INspcGpNIITFNN.........................	0	6	6	6
+5074	PF05247	FlhD		Flagellar transcriptional activator (FlhD)	Moxon SJ	anon	Pfam-B_7623 (release 7.7)	Family	This family consists of several bacterial flagellar transcriptional activator (FlhD) proteins. FlhD combines with FlhC to form a regulatory complex in E. coli, this complex has been shown to be a global regulator  involved in many cellular processes as well as a flagellar transcriptional activator [1].	21.30	21.30	21.30	23.70	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.12	0.72	-4.03	29	772	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	693	6	122	317	10	100.70	60	90.55	CHANGED	Ms.ss-lLp-I+-lNLSYLhLAQphlppD+A.sAhFRLGISc-hADlLtpLo...AQllKLAsoN.LlC+FRFDDpt.llshL.Tpp.....s+scslsphHAuILhAupsscpl	...............MpTSELLKHIYDINLSYLLLAQRLIspDKA.SAMFRL.GIsEE.MAssLuuLT..LPQMVKLAETNQLVCHFRFDsHQ.TIopL.TQ-............SRVD....DLQQIHTGIhLSoRLLp..s......................	0	7	46	85
+5075	PF05248	Adeno_E3A		Adenovirus E3A	Moxon SJ	anon	Pfam-B_7497 (release 7.7)	Family	\N	25.20	25.20	25.40	37.00	21.60	24.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.78	0.71	-4.03	11	109	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	83	0	0	74	0	105.20	56	97.52	CHANGED	MssssA-hsRL+.....HhcHCRR.+CFAR-slphsYFplPc-H.pG........PuHGVRlslpsshcS+hl+hhstRPlLsEpcpGsoplolhCICs.pPuhHpsLhstLCutYN+s	.........pusuAELARLR.......HLDHCRRhRCFARE.utthIYFElPEEHPpG........PAHGVRITlEGsh-S+LlRhFoQ+PlLlE.R-pGsTTlTlYCICs.pPtLHEshCCpLCuEFNKs...............	0	0	0	0
+5077	PF05250	UPF0193		Uncharacterised protein family (UPF0193)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	23.30	23.30	23.30	25.90	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.56	0.70	-4.76	5	117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	86	0	77	119	0	176.20	35	81.17	CHANGED	hAupWPSsRVAKG..GlF..HosKApYTKETQDLIKVLMEESKLThLQR++Is-+LRsGEPLPlPcpP+hpQphs...phLs........Msst++NhKKRSLpsI.tSGAac.EhYh.PtcsK..sEKpKpKLQppMA.Gp+l.PDsGhRK+hPR++u-csh-hsEsDRhsELL-EINERsEWLsEMEALGQGKKYRslIpsQIAEKLRELccLDR++SpEs-huht.l	...............................................................................................................t.l..G..sha..ps....stYo.tTp-Ll+lhMcESKlo..hpp+pl.cph+pG.psLPh......p.....Ppsspp.........t..s...........................hh......t........h...+sh...p....hpss.sAYppp.a+..P.p.ss..+........hEKpKp+.LQs..hhA..G..............-.t...+.............................s.........h.tt....cp..t.....c..DhhpE..LlpEIpERtEFLs-MEuLGp.G+.pY.+shIhsEIup+l+chctl-pphp.p.p......h.............	0	29	37	56
+5078	PF05251	UPF0197		Uncharacterised protein family (UPF0197)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	23.20	23.20	23.20	23.90	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.62	0.72	-3.67	6	160	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	121	0	102	147	0	75.10	54	77.54	CHANGED	l-pMsRYlSPVNPAVaPHLAsVLLuIGhFFsAWFFVaEVT..........SoKasRslaKELLISLsASlFLGFGlLFLLLhVGIYV	................MpRYsSPVNPAlaPpL.slVLLuIGhFFTAWFFl...YEVT......................So..KhsRslhKELLlullASlFhGFGs....LFLLLhVGIYV..................	0	37	49	79
+5080	PF05253	zf-U11-48K	UPF0224; 	U11-48K-like CHHC zinc finger	Bateman A, Andreeva A	anon	Andreeva A	Domain	This zinc binding domain [1] has four conserved zinc chelating residues in a CHHC pattern. This domain is predicted to have an RNA-binding function [1].	21.10	21.10	21.60	21.30	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.14	0.72	-6.90	0.72	-4.20	84	695	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	184	2	441	662	1	26.70	35	12.17	CHANGED	clhsCPasssHpl.tpclptHltp.Cpc	.....hh.CPasssHpl.tsclppHltp.Cpp....	0	121	173	310
+5081	PF05254	UPF0203		Uncharacterised protein family (UPF0203)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	21.50	21.50	22.00	22.30	21.20	20.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.60	0.72	-4.12	19	246	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	207	0	182	247	0	68.30	36	54.14	CHANGED	Ms..ShutECs-hKccYDpCFNcWYuEKFL....KGctsp..stCschaccYppClppsLpc+sIp......ph.L-pu+cc	............Ms..Slu.pCs-lKccYDsCFNcWauEKFL...................K.G..pssp.......stCsplacpYppClpculcc+tIt......ph.httt+.................................	0	65	101	149
+5082	PF05255	UPF0220		Uncharacterised protein family (UPF0220)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	25.00	25.00	25.70	25.50	23.00	23.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.02	0.71	-5.00	24	399	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	275	0	246	338	0	149.70	34	93.88	CHANGED	Mst..p..haRh.....ch.tsspt+phulYlAGsLFuhGaWhhlDAulaSpps.p.st...l.......HlsFlDWlPhlhSTlGhllVNSI-KupLp...s-uhup.............usssAhtARlhLFlGFuLhAGGluGolhVhllKallpth.shsslhhGlANllsNshIhlSsllLWhup.shEDEYs	...............................p...h+......ph..stptpshushsAGsL........FhhGaWlhlDAulh.sp..p......................................plsas..ahsGlhuoluhlhlNuVp.puplpu.-uast.....................GshsthtARlhLF.lGFhLhhGuLhuShhlLhh....talsp......................ths...sla.GlAshh.pNshlhhu.sllhhhup...hE-.a...............................	0	76	123	193
+5083	PF05256	UPF0223		Uncharacterised protein family (UPF0223)	Bateman A	anon	SWISS-PROT	Family	This family of proteins is functionally uncharacterised.	25.00	25.00	31.60	31.50	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.91	0.72	-3.87	35	928	2009-09-10 20:58:59	2003-04-07 12:59:11	7	3	925	2	80	364	1	84.60	50	95.57	CHANGED	hsYpYPLDh-WSTEEllsVlsFastVEpAYE..pGlcp-cLLssY+pFKplVPuKuEEKpls+-FEcsSGYSsY+sV+pAKcssct.hlph	...hpYpYPlDh.s.WosEEhhtVlsFaspVEpAYE..suVpsccllsuY+pFKplVPSKuEEKpls+EFEpsS.GYShY+uVQtAKppsct.plp.l.............	0	18	40	63
+5084	PF05257	CHAP	AXE; 	CHAP domain	Bateman A	anon	Pfam-B_2845 (release 7.7)	Domain	This domain corresponds to an amidase function.  Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where is functions as a glutathionylspermidine amidase EC:3.5.1.78 [1]. This domain is found to be the catalytic domain of PlyCA [4].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.95	0.71	-4.47	47	5579	2012-10-10 12:56:15	2003-04-07 12:59:11	11	106	1721	22	443	2917	78	122.10	25	30.57	CHANGED	pthttpssshst.tsastsQCs.astphhtphss...........h.phhGNAts..........Wstss.thpua........ssstsPpsGslhsa..........tsssssYGHVAhVppV...tsssslpl.EpN..........h..tshshtshcph.st.......s.hsaIh	..........................................................tht........hsttphYstuQCT...ha..shphh..hus...............h.s.hh...G....s...Aps......................Wss.sA...ttpua......................psspsPp.s.Gu.lh.h.............tsssusYG..HVAhVppV...............s.s.s...s...l..p.luE.N..............a.....t.s...h...hhs.+sh.t........t.htaI..........................................................	0	112	217	369
+5085	PF05258	DUF721		Protein of unknown function (DUF721)	Moxon SJ	anon	Pfam-B_7527 (release 7.7)	Family	This family contains several actinomycete proteins of unknown function.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.51	0.72	-3.77	167	2098	2012-10-01 19:58:36	2003-04-07 12:59:11	7	3	2068	0	633	1679	1349	88.60	18	55.78	CHANGED	sls.pllpph.h..pp..ttht.pshthsplhp.tWppll...GsplAppspshpl.c...............su........s..LhltsssushtppL.phhptpllpclspth.s.....thlpclpl	...................................tthhpph.hpt....tthp.pshthtplhp.pWppll.............G.splu....spscshpl..c..............................su........s..LhltssssshuppL.ph.hpspllpplppth.s.........tslpplph.................	0	197	420	538
+5086	PF05259	Herpes_UL1		Herpesvirus glycoprotein L	Moxon SJ	anon	Pfam-B_7535 (release 7.7)	Family	This family consists of several herpesvirus glycoprotein L or UL1 proteins. Glycoprotein L is known to form a complex with glycoprotein H but the function of this complex is poorly understood [1].	19.60	19.60	20.10	20.90	17.50	16.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.40	0.72	-4.59	14	77	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	36	1	0	71	0	104.90	33	53.27	CHANGED	shshtshhssslssILphsChs....sshhhsh.sspshspsl.sGIhl+scCssPEslLWacpsppAYWVNPalsspGhh..EDltcsthssss.........+stlhpsLssth	.............................hhhtshhspplusILclsCls.s..cshsaph.sss.....shs.sl.sGIhl+hcCss.EslLW.cpstpAYWVNPalhltGhh..-Dlscsuhs.sss.........hctlhpuLssh.t.........	0	0	0	0
+5088	PF05261	Tra_M		TraM protein, DNA-binding	Moxon SJ	anon	Pfam-B_7584 (release 7.7)	Family	The TraM protein is an essential part of the DNA transfer machinery of the conjugative resistance plasmid R1 (IncFII). On the basis of mutational  analyses, it was shown that the essential transfer protein TraM has at least two functions. First, a functional TraM protein was found to be  required for normal levels of transfer gene expression. Second, experimental evidence was obtained that TraM stimulates efficient site-specific single-stranded DNA cleavage at the oriT, in vivo. Furthermore, a specific interaction of the cytoplasmic TraM protein with the membrane protein TraD was demonstrated, suggesting that the TraM  protein creates a physical link between the relaxosomal nucleoprotein  complex and the membrane-bound DNA transfer apparatus [1].	25.00	25.00	34.30	33.90	24.00	20.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.28	0.71	-4.08	8	222	2012-10-02 15:10:05	2003-04-07 12:59:11	6	1	171	17	11	121	0	120.70	70	98.53	CHANGED	MPKlQsYVSspVhEcINsIVEcR+tEGAc-pDVSFSSlSSMLLELGLRVYEhQhE+KESGFNQhEFNKlLLEsllKophhss+ILslpsLos+lsuss+F-apsllpsIcccVpEpM-hFFP-s-DE	.MA+VplYlSs-lh-KINtIlE+RRpEGA+-+DlSaSusuSMLLELGLRVYEA.....QMERKESAFNQsE.FNKlLLECVVKTQSoVAKILGIESLSPHVSGNPKF.EYANMVEDIREKVSuEMERFFPcND-E........................................................	0	0	0	6
+5089	PF05262	Borrelia_P83		Borrelia P83/100 protein	Moxon SJ	anon	Pfam-B_6712 (release 7.7)	Family	This family consists of several Borrelia P83/P100 antigen proteins.	25.00	25.00	25.20	25.20	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.78	0.70	-6.22	3	126	2009-09-13 12:24:55	2003-04-07 12:59:11	6	7	67	0	21	122	3	520.80	46	87.98	CHANGED	++ElDpV.NtTlEFlNYsGPHDsVDSA-sIRGIGEsLAuAL+uGsAGDp..uRYuVIHsVDPpsKcGhDADIFIIGupAcVDHIsNlRcIlAGYLpAAYGYccpDAcTIA+FlTIYNAVYRuDLDaFKp+YKpVVTKsLTKE+AGLARRYDQWPGKTQIVIPLocptaSGsl.SuVDTsSISDKKVVE+LREDs-KsV-hRRDMlDL..............................................KERESQEuAKRAQ.hKcEuDpKQc-ADKtppcADpAQcsADKQR+EscQKQQE.......AKNuP-PAcTousKEDK+V...........A......EppK+EhEKuQpEscKssEEApKAKDpt......A--LK+E..uKupEK.......hAEcKotEAQ+-Rc-VAu........................................DhQKhhsps+AcsTutu--....AI-SSsPsYGLKVVDsp+hLSELVLlDLKTEscLRoSulpTIRsRsLYpcsKsLVAIAsT.SGNAslpLVcIDsKoLEVlKESspcIAupSsLl+sup.hhsul..pDDssKWhlu+assK.L-..hhStsclLPaTsa	.......................................................................................................................................................................................................................................cKL+DFV..N.hDLEFVNYcGPYDSosTYEQIlGIGEFLA+s..Lh....su..sS..NSsh....hGKYalsRaID-pDKKu.SsDlFSIGucSpLDSILNLRRILTGYLhcuFcY-+uSAELIAKsITIYNAVYRGDLsYYKthYIpsuLKsLoKENAGLSRVYSQWAGKTQIFIPLK+sILSGpl-SDIDlDoLVT-KVVsuLLo.ENE.u.GVsF.AR..DlTDIQsEh+csDQcKIDhE.sshcp.c......................................................................sp.ppphps.pcp.pctos-ppcKE.IESQlDAKK+Q..KEEL.D.....cK..shc....LDKAQ.......QK..L.D...tuc.-sLDlQ.RcsV.+EKlQEsIschN+-KNLP.KPG.DV.SSPK.V....DKQLp.........tphQtp.p.........cssDEsQKREIEK..QIEIK..KsDEE.LlK.sKDt+.......AhDLpp-.....SKuSSKp................................p.hsEcKch.-......uK+phcsluc..............................................................................hsLQcscsQs+sps..T..shsp-........ul-SusP..VF...LEVI..D.Ph.T..NL.GsLQLIDLsTGscLKcSsppGIpR.....YGlY.ER-+D........LV...................VIKh-.SGc....AKLQ....lLs.KhENLKVlSESsF.EIs+sS.SLYVD.S+MILVsV..cDsussW+LAKFSscsL-cFlLSEscIhPFTSF.................................	0	11	14	16
+5090	PF05263	DUF722		Protein of unknown function (DUF722)	Moxon SJ	anon	Pfam-B_6789 (release 7.7)	Family	This family contains several bacteriophage proteins of unknown function.	29.80	29.80	29.90	31.40	29.70	29.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.73	0.71	-4.01	7	87	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	63	0	15	69	1	127.80	31	92.67	CHANGED	MADKLDRIIuDYlsG+LpA+IKuhE.Ralh+pKsD.NLGhRTA.sGsuc..uphLppEt.EsDcELh+L+cphphlshaacsLhtp.EKclIpL+apthtthoWYpVh.cLs......ls.ppA+phahpF+psIhph	..........................MAD+lDclluDYhsGhlpscIcth..c...chhh..+.ppsD..NlGhtsu.sssucsEscslhp...EsDccLt+Lcc.hphl-hhhpsLhs-....-KclI.pL+appt.tthTWhpVu.cLs......lscppA+phhhpF+p.l...h...........................	0	5	5	11
+5091	PF05264	CfAFP		Choristoneura fumiferana antifreeze protein (CfAFP)	Moxon SJ	anon	Pfam-B_6800 (release 7.7)	Family	This family consists of several antifreeze proteins from the insect Choristoneura fumiferana (Spruce budworm). Antifreeze proteins (AFPs) and  antifreeze glycoproteins (AFGPs) are present in many organisms that must survive sub-zero temperatures. These proteins bind to seed ice crystals and inhibit their growth through an adsorption-inhibition mechanism [1].	25.90	25.90	27.10	26.90	25.30	25.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.89	0.71	-4.40	4	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	4	17	0	49	3	59.70	45	103.26	CHANGED	MKhhMLIMALA.IsTVSSDGoCsNTNSQlotNSpCV+SThTNCYIDNSpl...............................YsTTCTGSpYDGVaITSSTTTGTpISGPGCoISoCTITtGVsAPSAAC+ISGCTLpAN	..............................lo.NS.C.pSThTNC.lspSpl...........................pSpl.toTCTsSpas.GlhIToSToTsoph....................................	0	0	0	0
+5092	PF05265	DUF723		Protein of unknown function (DUF723)	Moxon SJ, Finn RD	anon	Pfam-B_6852 (release 7.7)	Family	This family contains several uncharacterised proteins from Neisseria meningitidis. These proteins may have a role in DNA-binding.	20.90	20.90	21.10	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.12	0.72	-4.17	6	74	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	23	0	6	29	9	60.50	46	34.44	CHANGED	huhTFppAtochs-+FPc..lpLlcFsGltcPsoIsCPhHGsVshSsa.puhI+SKaGCPcCu	.....................huhoFppAtu+hpp+FPc...lsLl-FsGlhtPsolpCPhHGsVphusa.puhl+.SK.h.G..CPcCu.	1	6	6	6
+5093	PF05266	DUF724		Protein of unknown function (DUF724)	Moxon SJ	anon	Pfam-B_6894 (release 7.7)	Family	This family contains several uncharacterised proteins found in Arabidopsis thaliana and other plants. This region is often found associated with Agenet domains and may contain coiled-coil.	25.10	25.10	25.20	25.10	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.22	0.71	-4.68	15	90	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	12	0	62	86	0	176.20	27	27.11	CHANGED	hhlP....FsK+tshWKshEohEVFKplPQuPHFsPLh.cscE-hREhsAlGhMloFhsLL-cVpsLplD-shSplpslspsFsELEKHGFNVpsPpSRIsK...lLoL+scpocph-EhKshEKchs-c...........p..-sthschEccIlELpRpt.hhpctKEst-.......pEIuphcopAsplcQplpss-h-FposhuAPW	..............................PFsKpt.hWp.hE.sh-VFchlPQpPHFpPL..ph..thREhhAlGhMhoFssLl-plppLpl-D.s.ts.hpshhc.slscLEc.pGFsVpslpsRLsc....LLsl+scpsphhcct+ph-cphtcc.......t....pph-pphtcl-pclh.....cLccpt..htphppttp.................t-lsphpspsptlppphtshchcFpshhst..............................	0	10	24	45
+5094	PF05267	DUF725		Protein of unknown function (DUF725)	Moxon SJ	anon	Pfam-B_6905 (release 7.7)	Family	This family contains several Drosophila proteins of unknown function.	20.80	20.80	21.10	22.90	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.77	0.71	-4.22	11	174	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	15	0	81	172	0	122.40	25	50.34	CHANGED	sssshospCFshYlPhlNpluspasssYssClssAssptpslssphppsppslppSuppsCssh.psC.......sohssshshFpCaAssusssspshYsISuNAopuAsplpcphpslcspc.pCsNpTp+s	.............shpCFshYhshhsplsspYstsYstChsstpssppplspphpppppplpssspphCssl.psC.......s..sh.sss.h.s.hFsCaussuspsspshaslusNAo..ptssplppphphlphpcttCsspupp..........	0	11	12	50
+5095	PF05268	GP38		Phage tail fibre adhesin Gp38	Moxon SJ	anon	Pfam-B_7415 (release 7.7)	Family	This family contains several Gp38 proteins from T-even-like phages. Gp38,  together with a second phage protein, gp57, catalyses the organisation of  gp37 but is absent from the phage particle. Gp37 is responsible for  receptor recognition [1].	25.00	25.00	31.70	29.40	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.92	0.70	-4.96	8	76	2009-09-11 08:17:54	2003-04-07 12:59:11	6	1	63	0	0	45	2	168.10	45	71.99	CHANGED	MAVVGlPGWIGpSAVsETGQRWMsuAApcLRlGlPsWMSsMAGRS+EIIHTLGADHNFNGQWFRDRCFEAGSAPIVFNITGDLVSYS+DVPLFFMYGDTPNEYVQLNItuGVsMYGRGGNG....sussusGosGGcsIQNDIGGRLRIsNsGAIAGGGGGGGG...su..suatsphssGGGGGRPFGsGG...suuthSGGsAS....louPGuGu...ussstasGGsGG-VGuuGGpuh...GtssppssGGAAGtAVhGSAPTWpNVGsIYGsRV	.................................................sGWlGSSAVsETGpRWMuuAuspL+L.usPhaMSQMsG+Shp.h.holGt...............................................................................................................................................................................................................................................................................................	0	0	0	0
+5096	PF05269	Phage_CII		Bacteriophage CII protein	Moxon SJ	anon	Pfam-B_7453 (release 7.7)	Family	This family consists of several phage CII regulatory proteins. CII plays a key role in the lysis-lysogeny decision in bacteriophage lambda and related phages [1].	21.30	21.30	21.30	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.11	0.72	-3.98	3	497	2012-10-04 14:01:12	2003-04-07 12:59:11	6	2	366	12	19	217	1	84.00	41	89.93	CHANGED	MspAS....TR+EAsRIESuLLN+IAhLGQRKlA-AlGlcESQISRWKsDWIPKhSMLLAVLEWGVsDD..-lARLAKpVAclLTKKKRPsC.TERSE	...................M..ss....pp+..c..ssRhEosLL.pLuhlsQ+shAchlGspESplSR.......s.......-...ah...hhu...hL..hA...aGhss-........hu+h.h+hshs.hl.....T.pcKtPss.sE...................................................	0	0	4	12
+5097	PF05270	AbfB		Alpha-L-arabinofuranosidase B (ABFB)	Moxon SJ	anon	Pfam-B_7464 (release 7.7)	Family	This family consists of several fungal alpha-L-arabinofuranosidase B proteins. L-Arabinose is a constituent of plant-cell-wall poly-saccharides. It is found in a polymeric form in L-arabinan, in which the backbone is  formed by 1,5-a- linked l-arabinose residues that can be branched via  1,2-a- and 1,3-a-linked l-arabinofuranose side chains. AbfB hydrolyses  1,5-a, 1,3-a and 1,2-a linkages in both oligosaccharides and  polysaccharides, which contain terminal non-reducing l-arabinofuranoses in side chains [1].	21.30	21.30	21.60	21.90	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.95	0.71	-4.49	11	334	2012-10-02 19:42:32	2003-04-07 12:59:11	8	53	174	16	174	358	3	131.80	27	13.91	CHANGED	lS.l+soossYssRYlsHsuoTlNTpVVSSuSussl+pp.......ASapVpsGLAsuu.....ChSFESsDsPGoYlRH..tNFpLhlsANDGoctFpcDATFCPpsGlsu..pGs.SlcSasYPsRYlRHYsNlLalsusuG...a-ssssFpsDsoFhlt	....................................................................................l......tt.....s.....s.hps.sss............p.........us.atl.s.s.G.....L...us.ss.....slShES..sshPGhaL.R.H......tsh.pltLs...t..s...-.u.o..shFppDAT.F..phpsG...hss..sGh..........ohcShs..hPs.p..alR..H.h.s.....h..lhlst..........ttst.aptcsoFhht...............................	0	38	89	139
+5098	PF05271	Tobravirus_2B		Tobravirus 2B protein	Moxon SJ	anon	Pfam-B_7517 (release 7.7)	Family	This family consists of several tobravirus 2B proteins. It is known that the 2B protein is required for transmission by both Paratrichodorus  pachydermus and P. anemones nematodes [1].	20.90	20.90	21.10	197.70	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.56	0.71	-4.40	4	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	3	0	0	13	0	117.70	63	47.08	CHANGED	ssDWuohWPNDpLFlsDhhpLVWFDhhsDhVchpHFsuQsssDLSsIPKuFlSFlDNRlPMCINHKGhVYIRVt.su--sYYQKFG-LDVSsFsDshLPPDh-FsFsKVshssscpl.	NGDWuoKWPND+LFlDDFGKLVWFDlLsDlVcIoHFVSQsPTDLSsIPKSFISFIDNRlPMCINH+GWVYIRVKh-u--VYYQKFGELDVScFGDShLPPDFEFsFsKVTssVD+pLV	1	0	0	0
+5099	PF05272	VirE		Virulence-associated protein E	Moxon SJ	anon	Pfam-B_6573 (release 7.7)	Domain	This family contains several bacterial virulence-associated protein E like proteins. These proteins contain a P-loop motif.	21.50	21.50	21.50	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.18	0.71	-4.84	10	1163	2012-10-05 12:31:08	2003-04-07 12:59:11	6	20	659	0	186	1048	243	191.70	28	33.69	CHANGED	YLcul..pWDGhPRl-ohFhD......aLGsEDspYsptso+hahhuuVARVa.....cP..GsKaDalllLpGsQGsGKSThlctL.GGc..WFoDo...lcshcsKDthptlpGsWIsEluELsuhs.Ku-lEsIKuFITRocDpaRssYG+pspsaPRpslhVGTTNccEaL+DsTGsRRFaPlpss.K..plsh....s-hhpt.h-QLaAEAhhhYcc	.............................................................th..tWD.Gh.pR.lpt.....hhhp.........hls.......s....p....s..s..t.......h.s......p......h....++ahluhlA..+...sh.....ps....ss..+...h...c..h..s..ll.L..h.G.s.Q.G.hGKSTa....h.c.....t..L....s..sp.......a.a.oDs........l.p...t..h.....p..s..+....-.s..h.....p....t....l..pt.h....hllp....hs.E.hsu.hs...ppp..h.p.tlKshlo....cphsphRhsYs..c..p.s.pchsRpssFlGToN.p..p.-......a..L.p.DtT.Gs.RRFhslpVp.s....hch..........c.................hpQlaApAh.h...t.................................................................	0	95	149	176
+5100	PF05273	Pox_RNA_Pol_22		Poxvirus RNA polymerase 22 kDa subunit	Moxon SJ	anon	Pfam-B_6584 (release 7.7)	Family	This family consists of several poxvirus DNA-dependent RNA polymerase 22 kDa subunits.	25.00	25.00	79.50	79.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.04	0.71	-4.65	10	53	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	43	0	0	34	0	182.10	69	99.44	CHANGED	MNpHNV+YLAKILCLKsEIh+cPYAlISK-llp+Yss-lcYGDLVTlITVpHKlDss+TVFQVFNESSVsYoPlEcDYGEPIIITSaLQpGHNKFPlshLYIDlVASDlFP+FsRLos-ElsllsSlLQsGDsK..poLKLPKMLETElusKILYHKDhPLKlVRFa+NNMlTGlEluDRuVlsVl	.MNQaNVKYLAKILCLKTEItRDPYAVIsRsVlhRYsTDIcYsDLVTlITV+HKIDohKTVFQVFNESSlsYoPV-DDYGEPIIITSYLQ+GHNKFPlNFLYIDVVhSDLFPoFVRLsssEssIVsSVLQsGDuK..coL+LPKMLETEIVsKILY+PsIPLKIVRFFRNNMlTGVEIADRSVloV..	0	0	0	0
+5101	PF05274	Baculo_E25		Occlusion-derived virus envelope protein E25	Moxon SJ	anon	Pfam-B_6633 (release 7.7)	Family	This family consists of several nucleopolyhedrovirus occlusion-derived virus envelope E25 proteins.	20.70	20.70	211.80	211.40	18.70	18.00	hmmbuild  --amino -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.15	0.71	-4.68	17	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	53	0	0	53	0	183.90	52	84.15	CHANGED	upS.uDSlQhs.p.GphsVK.hNss+lKslRlhaGD..NcISKlhVuEpPLoYs-IlDcGN+.VGsNsVFlGslp-shsss................sssssRsTuNFsIKQFKNhFIVFKsl-.ocIcpsssMlRYEu-uMVYsLIDuosoolP-.LRDV.....SYPIsVhTsNussQLhLKEWsYTQINDuGTLFlKNEKSFR	....spS.SDSlphssp..GphsVK.h.Nss+lKslRlhHGD.....N...KlSKlaVAE+PLoYs-Il-cGN+pVGsNsVFlGTl.-sussS...............s.sssssRsTuNFDIKQFKNhFIVFKsl-ssKIccsssMlRaEuDGMVYCLIDussoolP-..LR-V.....SYPIsVYTsNussQLhLKEWsYTQINDuuTLFlKNEKSFR.....	0	0	0	0
+5102	PF05275	CopB		Copper resistance protein B precursor (CopB)	Moxon SJ	anon	Pfam-B_6721 (release 7.7)	Family	This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every  organism. CopB serves to extrude copper when it approaches toxic levels [1].	20.80	20.80	22.10	20.80	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-10.93	0.70	-5.10	81	554	2012-10-03 17:14:37	2003-04-07 12:59:11	6	4	422	0	149	499	67	205.50	41	65.28	CHANGED	ssthhthlhhDcLEhptsc..sssu.hsW-spuWhGsDhsRlhlKoEG........Ehppuc..h--u-.sphLau+AIuPaWDhQsGlRtD..htss.s....sRsaushGlQGLAPYaFEl-ushaluccGcsuhRlEuEY-lLLTQRLILQPclEsshhup-DsppulGuGLosh-hGLRLRYE.lsRpFAPYlGVsapppaGsTADhsRspGccsspsphVsGlRhWF	...................................s..th.hhlllDpLEhppsc..ss.ss..huW-spuW.lGuDhsRlal.+oE.G...........EpspGc...sEsu-...sphLau+ulu..PaWDl.uGl..RpD........hps...u..s.........sRsW..A.AlGlQG...LAPYhFEs-uosalupsGpsuhRLcuEYDlLLTpRLILQPphEsshhupcDsppuhG.sGLoss-hGLRLRYE.lp.RcFAPYlGVsasppaGpTu-hs+tpG-.p....s....ppspalAGlRhWF.........................................	0	40	89	124
+5103	PF05276	SH3BP5		SH3 domain-binding protein 5 (SH3BP5)	Moxon SJ	anon	Pfam-B_6742 (release 7.7)	Family	This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk).  Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule [1].	23.00	23.00	23.10	23.50	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.60	0.70	-5.05	8	259	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	95	0	164	239	2	194.20	41	52.73	CHANGED	Es-E...lDPRIQtELE+LNpATD-IN+hElELE.......................................................................EA+spFRplLhEuscKLcsluKKLGssI-KARPYYEA+chA+pAQhEsQ+AAhcFpRAsplhsAAKEpVuLAEQpLhppsp..phDsAWQ..EMLNHATp+VhEAEpp+scuEspHpcps+thppApp+lppLEcch+RuIpKSRPYFEhKtpapppLEsQKtpls-LEtcVppAKssYosALRNLEpISE-IHppRpstu....ssuscpsus	.....................................................................................................................ht.plp.ELEcLNpuo-pINphEh....pL-.......................................................................-A+.ppaRplL..Eush+Lpt.sp+lG.p.s.l.-cu+PYaEA+phA+pup.EsQpAs.papRAsphhtAA+Ehl.........lAEQtlht..........cpt.....ph...DssWQ.....EMLNHATp+V.-AEpp+hcuch.HpcssthhptA.t+hptLp+p.L++uIt...KS+PYFEhKup.......a...Lcp...KtpVppLptplstA.KtpYp.AL+NLEpIS-pIHtpRpt..................s...........................	0	51	64	122
+5104	PF05277	DUF726		Protein of unknown function (DUF726)	Moxon SJ	anon	Pfam-B_6757 (release 7.7)	Family	This family consists of several uncharacterised eukaryotic proteins.	22.60	22.60	22.80	23.00	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.19	0.70	-5.56	9	559	2012-10-03 11:45:05	2003-04-07 12:59:11	7	18	287	0	381	563	32	271.90	31	41.08	CHANGED	++hKRhhhlGLAsluGuhlIGlouGLtAPlluAGlushh......GssGsss...hLuus.uGsA.llsuhhushGAtlsuhtMp+RsuslcsFpFhPLpsspp............tslhVslss.h.hus.c-lptsWpsLs.s......s-hYuLtWEschLhphGpsl.slLhStshshshQpl.LttTl....................LsuLhuAlpWPhuLhKlu.llDNPWslshcRAhpAGchLA-sLhsRsh.GhRPlTLlGaSLGARlIa.CLhpLuc+.cthGllENVllhGsPssschc.WpphRoVVSGRhVNsYscsDWlLuaLaRssust..pluGhusls...hpslENlDsoslVpGHLsYpcphsplL+tlshc	..................................................................................................t....+hhhhGhAslsGuhllul..ouG.LhAPhluuuh...ushh.............Ghsuhsu.................lus.........h....u.t...s.......hhss.hshhG.uths.s.hhhtphh.t.tlppFthhslttstt....................................................plhlsl.h...h........t.p...p.shhhPa.p.hlt....................t-.aslhWEsphLhphGpsl.phl.h.st.h.h....s..s....hpph.lt.Tl................................................................................hssl.huul.hP.h....s..L.h.p.hu...h.lDNsa..slshs.RuttsG.thLA....c....s....Lh...p...+t......GpRP.lT...LlGaSLGuRlIa.CL.p...L...Ap..........c......t......shG....l..lps.Vhlh.G.uPhss..........p....t....pp....at..........h....+.pVV...u...GRhlNsY.....s..psD..alLu..................h...laR.........t.s.....t...h.........th....t..........lu.Gltslp..........t.......l-..Nhshoph.l.tu.Hh.pY.........hstlLpthth.............................................................	0	135	225	323
+5105	PF05278	PEARLI-4		Arabidopsis phospholipase-like protein (PEARLI 4)	Moxon SJ	anon	Pfam-B_6763 (release 7.7)	Family	This family contains several phospholipase-like proteins from Arabidopsis thaliana which are homologous to PEARLI 4.	27.90	27.90	28.30	28.00	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.63	0.70	-5.02	6	68	2009-09-11 21:08:31	2003-04-07 12:59:11	7	5	8	0	42	67	0	216.70	24	49.53	CHANGED	s-ptslhLFP-lhhs.psp.sScs.........................................................pp.ppptppEssEL..........................-hpShhS-Sa..VSVGpY+VRuSVSoTLQuIlDKHGDIAusSKLQShuTRSYYLEsLAuVVhELpSTPL+pLocsRVtEMlAVVKDlESVKIcVGWLRoVLEElsEAscaastpEssssEKEspE+clhhcKpEMEtppp-Lsc+EKElKEhRc+lpEhsu+LG-LEMKRsRL-KphshhuSKVEKF.cGcohlcc	....................................................................................................................................................................................................................................................................................h..s-sh.....VpVstYpVctShsshLptIlcKHGDIuusscLpShphRShYLEsLssllp-L..p.poslc.pLocsclp-hhuslpDl-ssplcVuWL+s...tLsE...lh..-s..hchh.......s.phctschc+ctpc+c.lpttcpEhEt...pp-LtphEpcht-hptph........http.....hsphp....th......h..p...........................................	0	14	24	27
+5106	PF05279	Asp-B-Hydro_N		Aspartyl beta-hydroxylase N-terminal region	Moxon SJ	anon	Pfam-B_6767 (release 7.7)	Family	This family includes the N-terminal regions of the junctin, junctate and aspartyl beta-hydroxylase proteins. Junctate is an integral ER/SR membrane calcium binding protein, which comes from an alternatively spliced form of the same gene that generates aspartyl beta-hydroxylase and junctin [1]. Aspartyl beta-hydroxylase catalyses the post-translational hydroxylation of aspartic acid or asparagine residues contained within epidermal growth factor (EGF) domains of proteins [2].	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.86	0.70	-4.52	9	236	2009-01-15 18:05:59	2003-04-07 12:59:11	6	14	40	0	49	199	0	177.80	40	49.29	CHANGED	NGR+GGlSGu.SFFTWFMVIALLGVWTSVAVVWFDLVDYEEVL...............GKL.GlYDADGDGDFDVDDAKVLLG....lK-+.hsc...................................t.s..cEt-shsc.Ettlshctphpplc-ElKEQlpplhcchVhsc.......pp.ct.stE.p.-tc+hhhtsDsD-phcs.tssts+EEhEt.h..Ech.p.t.....cEhsscpcsscspEsVp..cstch+tcsscVs.psh-cp.....................pt.h-pt....Ech.h.ssEcppcsP	............................................ts..ShhoWhhVIALLGVWTSVAVVaFDLVDYcpVl..........................................GKL.ulYD.ADGDGDFDl-DAKVLLs..............hppt....p.........................................................t......h...tt.....th.t.p.....tc.p.t....t....c....................................................t............pt..............................................................................................................................................................................................................................	1	3	7	23
+5107	PF05280	FlhC		Flagellar transcriptional activator (FlhC)	Moxon SJ	anon	Pfam-B_6773 (release 7.7)	Family	This family consists of several bacterial flagellar transcriptional activator (FlhC) proteins. FlhC combines with FlhD to form a regulatory complex in E. coli, this complex has been shown to be a global regulator  involved in many cellular processes as well as a flagellar transcriptional activator [1].	20.60	20.60	21.00	21.40	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.17	0.71	-4.80	23	831	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	727	2	135	359	15	173.70	64	90.40	CHANGED	Mu..pKS....llsEucpIpLAhELIpLGARLQlLEoETsLSR-RLl+LYKEl+GsSPPKGMLPFSTDWFhTWpPNIHSSLFhNIYpaLhcpussssl-AllKAYRLYLEplst.pphEP.....l.......LSLTRAWTLVRFhDusMLphopCspCGGcFVsHua-.ppsaVCGLCpPPSRAGKo++suspt	..........................................................MuEKSIVQEA+DIQLAMELIsLGARLQMLES.ET.Q....LSRGRLI.KLYKE..L.R..G....SP...P.P.KG..M.LPF..S..T..DWFM..T..W.EQ.N.l..HASMFh.NAapFLL..Ko.....G..h.Cs..GV...DAVIKA..YRLYLE....Q..CPp.....s..c..-sP..L.......LALTRAWTLVRFVE......S......G.l......LpLSuCNCCGGsFI..T.H....A..H....Q....P.s.s.SF..sCSLCQ...P....PSRAVK+RKLSp.ss...............	1	10	53	95
+5108	PF05281	Secretogranin_V		Neuroendocrine protein 7B2 precursor (Secretogranin V)	Moxon SJ	anon	Pfam-B_6776 (release 7.7)	Family	The neuroendocrine protein 7B2 has a critical role in the proteolytic conversion and activation of proPC2, the enzyme responsible for the proteolytic conversion of many peptide hormone precursors. The 7B2 protein acts as an intracellular binding protein for proPC2, facilitates its maturation, and is required for its enzymatic activity. Processing of many important peptide precursors does not occur in 7B2 nulls. 7B2 null mice exhibit a unique form of Cushing's disease with many atypical symptoms, such as hypoglycemia [1].	25.00	25.00	44.70	38.80	20.10	22.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.66	0.70	-4.95	12	117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	88	0	64	114	0	200.70	45	85.95	CHANGED	hh......tlL.......hhsl.........tsAh.shsP..phhDplS..cschthhhcush-.................p.t.u..c.Ea.tHpu..LhG.QplpGGAtEG.p.........shst.hossslP.......uYssPPNPCPlGhT.tsDG..ClEsh.sTA-FSRcaQspQchh.DsEH.hasss.............................................sphp+sLlh+K..h+stp................tpcppcps.NPaLQGp+Lc.lsAKKsssph.	......................................................hhhh.......h......th.............sssh..uhss.......cssDpVS..-s-l.....pRLh+.GshE...........................phGlup.csEYssHpu...LhGsQpIp.GG..A...pE............GhQ.................+Lu......P.....G......N........IPN..ls....sEhT.scsl.P...................uYssPPNPCPl....GhT.scDG...CLEshssTAEFSREa....Qhp..Q....chh.DsEH.as.sh............................................................uphsKpLlhcK...h+stt...................Rpccsl.NPYLQ...G..p+.Lc.lsAKKus.hh.p........................	0	18	23	43
+5109	PF05282	AAR2		AAR2 protein	Moxon SJ	anon	Pfam-B_6782 (release 7.7)	Family	This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth [1].	20.40	20.40	20.60	23.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.37	0.70	-5.53	41	321	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	253	2	227	311	4	325.70	23	83.00	CHANGED	h............sslllhslP.ts.....hlGIDhhoassssp..F+GlKtlPs..G..hHFlahs.........................................................ppsshuhRhGhahhhp.........................tsclhlh+WspppEshh..ps...........pt....................pthptpspl.tphpph..LssYPh.........................................cshp.pWtsLT.shIs........pllp+lpshs........................................hhlsstpssppcpp...................................ttpptscpt.thtt..........................................................................psplpFs.l.....cpphppusss...........p-lTctshD+SahLppll................................pphpsp.ttlLGELQFuFlhhl.hhtsasuhpQW+pLlpLlssu.pphltp...ptph.....................ahpllclLhhQLt.............chsp-hhhD......hhppstFlt.hl........................htttltpphcplcshlppcashcl.........cs	...........................................hh..ssslllhslP.to........hGIDh.sapsssp.....F+GlK.lPP..G...hHFl.ahu.........................................................t...tphu.Rh..Ghah.hp.............................tp.lhlhcWsttpEpl....t.....................pt....................................................ch.t.tsph.tphcph...LssYsh.........................................pphp..pWhpLo.shl.o........shl..p+lts.s...ht........................................hls.sttt.tptcpp.........................................t...tp...h..................................................................................................tpphpFs.l........pphh.tssss...........t-hTptshDp...ShhLppll...............................................................tphtt...s..tplLGELQauFlshl.hh....tshpuhppW+.pL.l.p.Ll...........hps.ptsh.h.p....ctth..........................ahphlp.lLhhQLt........................phsp-hhh-.................hsts.shltphlp..................................................................t.........h..t.....t.....tl...hpthtphpthlpt..phtWph..t......................................................................................	0	74	122	184
+5110	PF05283	MGC-24		Multi-glycosylated core protein 24 (MGC-24)	Moxon SJ	anon	Pfam-B_6825 (release 7.7)	Family	This family consists of several MGC-24 (or Cd164 antigen) proteins from  eukaryotic organisms. MGC-24/CD164 is a sialomucin expressed in many  normal and cancerous tissues. In humans, soluble and transmembrane forms of MGC-24 are produced by alternative splicing [1].	25.50	25.50	25.80	25.80	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.58	0.71	-4.50	4	165	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	61	0	82	152	0	116.60	30	77.58	CHANGED	huRphh..hAAhCh.usLClLustps.sttssssths.hssssoshsssls.sT....psCE..phNsC.pClNsoh.ssohCsWhpCpsE..saCSutstV....usCp.tNoT-SCSs.sss.......sVsT.puTstPshps.uso.........sosppsTosssTNsTVTPssp.sRKSTFDAASFIGGIVLVLGlQAVIFFLYKFCKS	...................................................s...........................................................................................................................................................................spot.....ss..s................................................................................................s.tt....s.o...p...s...t...s.s...sT.s.oPs..s.........s...+...p....st......FDuuSFlGGIVLsLul.Alhahhh+Fh+u........................	0	8	13	28
+5111	PF05284	DUF736		Protein of unknown function (DUF736)	Moxon SJ	anon	Pfam-B_7619 (release 7.7)	Family	This family consists of several uncharacterised bacterial proteins of unknown function.	22.00	22.00	22.40	22.30	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.37	0.72	-4.21	66	445	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	185	0	238	454	42	101.00	34	87.91	CHANGED	ssI.GpFs...psp.suapGplcTLolsscl.plVPsps..ss-...sAPDaRlhsu.........ss.ElGAuWp+pupc....up-YlSlpLDDPsF.stPlhAsLhp...sp-sctt..asLlWsR.Ppc	.................sI.GsFs...pss..s.uasGplpTLsls.sch..pllPspp..ss-...pAPca..R..lhsu..........ssElGAAWp+pupc....Gc-YlSlpLDDPuF.suPl..hAsLhp....s-css.t...asLlWsRs...........................	0	36	145	190
+5112	PF05285	SDA1		SDA1	Moxon SJ	anon	Pfam-B_6906 (release 7.7)	Family	This family consists of several SDA1 protein homologues. SDA1 is a Saccharomyces cerevisiae protein which is involved in the control of the actin cytoskeleton. The protein is essential for cell viability and is localised in the nucleus [1].	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.31	0.70	-5.15	38	397	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	283	0	294	403	7	256.40	28	42.13	CHANGED	Ms....EsLLQDLspYK.....sSK.-KuVhMAARuL...........luLYRE........VsP-hLp+KDRGK.sAuhulpssctp.........taGcpps.sssI.GlELLtca.......t..ct-pu...ss-s-sDsp.............W...............................ps...t-ss-ssDs..cGpWlsVpsD...p..........................................................oDsEDEcp............................t..t.t.....p.phpsccpsppsppptp-.........................................stcpphspluoo..RILTPADFtKLpELRtptul..sphhsttt......................pcpp--hlsuscIEuhsKht..Kps+EERlApspEGRp-RpcatS....+Ks+Kcsts.pSTTN+EKpR.+KNFhM.hl+K.ts+uKpKpSlp-+ppsLRsHlt+p.....K+tt	.............................................................................................hscpLLpDLs..Y+.....pp+.sKsVhhAA+uL...........lpLaRp........lsPphLt++.RG+..sphthp.tt..t.................aGp.p..hs.l...GhE.l..Lt.t.............ttt.......tpptp.p-tt.............h..................................................................tt...ppp.ppDt........psth.h...s....spps......................................................................sDp-p.pt.......................................................................t....t.....t.tt....t............................................................ttttthttlsss..+lL.T.tD.ht+lp.hphptth...pth.ttt..............................................tptttchls.pplpt.hch.....Kts+.......-pRlttshtG+psRtcat................+tp+..t.h..tSpoN+cKt+.pKsh.M..h...h.tp...s+sKt....ph.S.hh.cpp..hhp..tt..+t.....p...t.................................................................................	0	106	161	235
+5114	PF05287	PMG		PMG protein	Moxon SJ	anon	Pfam-B_7710 (release 7.7)	Family	This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages [1].	29.00	29.00	29.40	29.10	28.10	28.90	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.55	0.71	-4.47	15	251	2012-10-03 03:07:01	2003-04-07 12:59:11	7	10	30	0	129	302	2	146.40	33	89.87	CHANGED	MSYsCsSGNaSS+ShtsphphPsoSsso..shPoslshssslCoPSopQhuSolhcsCQETCsEPhpCQssssp..............................sssCQsoCapPpsSslsuPCpoThuGsluFsSS..SCpshuh..........tSpsC.slG.sGSsuapslstsossh.shshhot..aC+Pshh.........uS+oh.Qs...............oCapPsCuSuh	............MsasssotshSopSh.....tshhhhPsssss.s...hssslshtsshh.P.S...oh...Q...hso.LhssC...QETChEPssCp.oss................................spsCQ..ss......C..pPp.....sh...h......ssP.Cps.sh..s.tsh..........u.asSs..........uCps.huh..........hopss.slu....ssS.....sshpslshh.sp.sh.s.s.hst......hCpP..h....................s.psh.ps................s.....h.................................	0	14	14	42
+5115	PF05288	Pox_A3L		Poxvirus A3L Protein	Moxon SJ	anon	Pfam-B_7718 (release 7.7)	Family	This family consists of several poxvirus A3L or A2_5L proteins.	25.00	25.00	98.30	98.20	22.20	20.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.29	0.72	-4.24	12	91	2009-09-11 10:15:31	2003-04-07 12:59:11	6	1	41	0	0	44	0	66.90	66	95.24	CHANGED	tYplsLcPP++C.SpC.sNLh-alp-Dccsl+hhLtSQPpKhplLKpFLshsRNKphhhKILDpEl+RVLs	..Yph.lp.PK+C.S.pChsNLhcalsEDuNs.I+hlL.SQPpKLKVLp-FLushRNKpFlYKILD-ElRRVLT.	0	0	0	0
+5116	PF05289	BLYB		Borrelia hemolysin accessory protein	Moxon SJ	anon	Pfam-B_7729 (release 7.7)	Family	This family consists of several borrelia hemolysin accessory proteins (BLYB). BLYB was thought to be an accessory protein, which was proposed to comprise a hemolysis system but it is now thought that BlyA and BlyB function instead as a prophage-encoded holin or holin-like system [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.27	0.72	-4.22	3	123	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	28	0	5	92	0	102.00	77	87.44	CHANGED	MKLSKNNLELGLTSLSTLIDIFSKFED.EFDEsAHKGFFLVYELYSHYKLIYTANMERLESALTPsIscTLAPINEKINQCIDLVNSDEKNLKISNDLKFNcEGKP	.......MKLSKDNlELGLTSLSoLIDIFSKFED.EFDEIAHKGFFLVYELYSHYKLIYTANMERLESALTPs.IstALAPLNEKINQCIDLVNSDEK.NLKISNDLKFNQEGKP..............	1	4	4	4
+5117	PF05290	Baculo_IE-1		Baculovirus immediate-early protein (IE-0)	Moxon SJ	anon	Pfam-B_7745 (release 7.7)	Family	The Autographa californica multinucleocapsid nuclear polyhedrosis virus (AcMNPV) ie-1 gene product (IE-1) is thought to play a central role in stimulating early viral transcription. IE-1 has been demonstrated to activate several early viral gene promoters and to negatively regulate the promoters of two other AcMNPV regulatory genes, ie-0 and ie-2. It is thought that that IE-1 negatively regulates the expression of certain genes by binding directly, or as part of a complex, to promoter regions containing a specific IE-1-binding motif (5'-ACBYGTAA-3') near their mRNA start sites [1].	33.10	33.10	33.10	87.10	32.30	33.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.13	0.71	-4.45	14	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	40	0	0	40	0	136.70	43	54.30	CHANGED	lpalsspspapashaIFlPYlKQLppIlpLFhNDaCCsKlVKphtssLssLlscSt+hL+sI+hhNcRhQVlNVFh-s..lYpCNICpDTSsEE+FLKPNECCGYpICNhCYANLWKaso..lYPsCPVCKTSFKSSssssppt	...................t.s.a.hNhalFlPYlKQLptllch.FpND.a.CCtKllpshthtLspLlscstchlcpIcshN+plpVhNVFh-s..sLYECNIC+-sSs-E+FLKPsECCG.YsICNhCYusLWKass..haPhCPlCKTSFKssp...........	0	0	0	0
+5118	PF05291	Bystin		Bystin	Moxon SJ, Wood V	anon	Pfam-B_7767 (release 7.7)	Family	Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy [1]. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localised in the nucleus [2]. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesise 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits [3].	28.00	28.00	28.20	30.20	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.76	0.70	-5.48	21	359	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	301	0	250	363	3	287.10	46	68.65	CHANGED	Fhs..ps..............spoLuDhIhpKIpE+-sph..........ptthtptps..hP..thsP+Vl-lYcpVGplLS+Y+SGKLPKAFKllPslssWEplLhlTcPcsWTPpAhatATRlFsSshpsptAQ+FhphVLLsRVR--Ip..EsKKLNaHLYpALKKALYKPuAFFKGlLFPLspossCTLREAhIluSVlsKlSIPlLHSuAALh+ls-h.........-asGssShFI+lLL-KKYALPY+VlDulVhHFhRFps.p..................cpLPVlWHQuLLsFsQRYKsDlop-Q+-tLlcLl+t+sHh.tIoPEIRRELhsupsRssp.s.sth	.............................................................t...phsLADhIhpKIp-+psp.................tt...h.t.t.....s.sh......s....plss+Vl-lYptVGplLo+Y+SGKLPK.sFKllPs..LpsWEp..lLhlTcP-p............WospAhYpAT.RIFsSshpsphAQ+......FhshVLLsRlR-DIt...EpK..............+LNhH.LY.........pALKK..ALaK.PuAFF.KGlLhPLs.poGsCTLREAhIluSlls+sSIPlLHS.uAAlh+ls-h...........-.asGss.olFl+lLL-KK...............YALPY+VlDulVhHFlRFcspp..................................cpLPVlWHQuLLsFsQRYKs......Dls.p-Q+-tLL-Llchp.s..H..pIsPEIRREL.sutsRs.....................	0	92	141	208
+5119	PF05292	MCD		Malonyl-CoA decarboxylase (MCD)	Moxon SJ	anon	Pfam-B_7770 (release 7.7)	Family	This family consists of several eukaryotic malonyl-CoA decarboxylase (MLYCD) proteins. Malonyl-CoA, in addition to being an intermediate in the de novo synthesis of fatty acids, is an inhibitor of carnitine palmitoyltransferase I, the enzyme that regulates the transfer of long-chain fatty acyl-CoA into mitochondria, where they are oxidised. After exercise, malonyl-CoA decarboxylase participates with acetyl-CoA carboxylase in regulating the concentration of malonyl-CoA in liver and adipose tissue, as well as in muscle. Malonyl-CoA decarboxylase is regulated by AMP-activated protein kinase (AMPK) [1].	19.00	19.00	22.20	19.60	17.90	17.80	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.18	0.70	-5.76	3	443	2009-01-15 18:05:59	2003-04-07 12:59:11	6	9	296	2	221	458	837	259.70	34	71.11	CHANGED	MLsEKFGsscEKLspAIshY..sKs-pthIpl+suAssSRscLl+slNchPGGTu+Vs-MRpplLA......SKsooSth+sLDlshs-lhsSWFSLGhLcLE+LsWooPu.ILpKltEYEAVH.ltGhp-hR+RLuPLsRRCFuF.HEsLAcEPLVFVEVALs-oVAcoIt-lhccGt.phpt--tTTAlaYSIossQPGLuGIsLGNFLIK+VlTcL+KDlPuVoTFuTLSPIPGFtpWLl+pLpupScasp......................pE+sl.hlSD.Sppt.NthEssETLLuVcss-WsTcK+pLsslE+ILMhLCARYLLsEK+.cG+ALDSVANFHLpNGAcLERLNWhGDRScKGIpQSaGIMVNYlY+	..........................................................................................t..........................................................................s.h.tlhpph.......s...t...uht.Ll.thRtclht.......................t......tlt.l-tthpph...hsp..WFshuhL.Lc.ls..W.p.o.PsplLpKlhtYE...........AVH.....l.p.s.W...Dl+pRlts.......RRCauFhHsthst..................-PLlhlcVAL.spthsssl..t....l.......l.....t...t....................t............t................................t........p..........p...s...s..s.AlFYSISssQ.GLtGlshGshLIKpVlppLp.........p.........-h......Pp.........lppFsTLSPlPGFhpWL.......t........................................................................................................................................................................................................................................................................t.h.p..hhthsAhYl..h..tt+p....p.....G....h..s.h....sPVApFHLtNGAhl.c..lNahuDhS.+GhppShGhMVNYhY......................................	1	76	127	174
+5120	PF05293	ASFV_L11L		African swine fever virus (ASFV) L11L protein	Moxon SJ	anon	Pfam-B_7869 (release 7.7)	Family	L11L is an integral membrane protein of the African swine fever virus (ASFV) which is expressed late in the virus replication cycle. The protein is thought to be non-essential for growth in vitro and for virus virulence in domestic swine [1].	25.00	25.00	159.30	159.20	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.77	0.72	-3.85	2	12	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	0	0	10	0	77.30	92	93.55	CHANGED	MLEPlLVMAPIPLlLIFLYSYFKIKLHKLITIALFLGCLFFILRDFCFPPMLWp.LpNhT.shNshLGNpSF.VpCpp	MLEPILVMAPIPLVLIFLYSYFKIKLHKLITIALFLGCLFFILRDFCFPPMLWTQLHNITSSIN.ILGNNSFQVKCNp.	0	0	0	0
+5121	PF05294	Toxin_5	toxin_5; 	Scorpion short toxin	Moxon SJ	anon	Pfam-B_7892 (release 7.7)	Family	This family contains various secreted scorpion short toxins and seems to be unrelated to Pfam:PF00451.	25.00	25.00	26.80	26.50	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.27	0.72	-3.74	6	25	2012-10-01 23:31:40	2003-04-07 12:59:11	8	1	11	2	0	29	0	32.20	66	72.07	CHANGED	CsPCFTTDPpMppKCpcCCGG+..GhChGPQCLC	ChPCFTTDPsMupKCp-CCGGp..GKCaGPQCLC.	0	0	0	0
+5122	PF05295	Luciferase_N	Luciferase; 	Luciferase/LBP N-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_7906 (release 7.7)	Domain	This family consists of a presumed N-terminal domain that is conserved between dinoflagellate luciferase and luciferin binding proteins. Luciferase is involved in catalysing the light emitting reaction in bioluminescence and luciferin binding protein (LBP) is known to bind to luciferin (the substrate for luciferase) to stop it reacting with the enzyme and therefore switching off the bioluminescence function. The expression of these two proteins is controlled by a circadian clock at the translational level, with synthesis and degradation occurring on a daily basis [1]. However This domain is not the catalytic part of the protein.  It has been suggested that this region may mediate an interaction between LBP and Luciferase or their association with the vacuolar membrane [2].	25.00	25.00	104.80	104.10	20.80	16.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.63	0.72	-4.18	13	14	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	8	0	0	14	0	81.60	58	8.43	CHANGED	MAs..QLspFLsN-AKlDs+VluYMT+pLpL-SVSDFANYWTSsEYE+GVQDDIlupVusFpss.SKPsuKlQlARLRAAW+uAQ	MAt..pLspFLss-AKlDs+VluYMT+pLpL-SVSDFANaWTosEYE+GVQDDIlupVssFpss.ScssuKlQlARLRAAW+uAQ.	0	0	0	0
+5123	PF05296	TAS2R		Mammalian taste receptor protein (TAS2R)	Moxon SJ	anon	Pfam-B_1498 (release 7.7)	Family	This family consists of several forms of mammalian taste receptor proteins (TAS2Rs). TAS2Rs are G protein-coupled receptors expressed in subsets of taste receptor cells of the tongue and palate epithelia and are organised in the genome in clusters. The proteins are genetically linked to loci that influence bitter perception in mice and humans [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.02	0.70	-5.53	20	1248	2012-10-03 04:04:29	2003-04-07 12:59:11	8	3	92	0	394	2541	0	286.50	29	96.76	CHANGED	Mhssh.slh.hllhlsEhllGlluNuFIsLVNsh-Wl+p++lSslDhILhuLAISRIsLlhllllssahhlhhsshatsuthhphlshhWhhhNphSlWhAThLulFYhlKIAsFSHPlFLWLKhRlspVlsal...LLuolllsh..lsplhpshp...........phppNoThphchpchphhhshlhhp..lsshlPFllsLlShhLLIhSLh+Hp+pMppsuoGhRDPsTcAHspAlKsllSFllLahsYaluhllphhshhhscsplhhhhs.hhshhYPssHShILILGNsKLKpshhplLtph+	.......................................................................................................................hh..h.hlh.h.hthhlGhhuNuF.I..s.lV.Ns.h.-W..l..+..p..p.c.l.u..s.sDhILhsL.ulSR.lh..Lh...h..l.l.hl.....sh.h.hhh.h..ss..hh.s..h.p..h...h...hphh.t.h.h.W....hhhN.ph.olWhuos.LSl.F.Y..hl.K...I..A...s.F.o.....p...sh....F.L....a..L.K.....h...R....l....s..p..l....l.....s......h.l........L.L....G.....s..l...l...h.s..h....h..........h..h...h....l....s...h.....t..h.....p.........h....h...h..t......t.h....................php.p..N....h.....T...h......p...........h.........p......h....p........p....h.....t.....h....h..............h.h..hh.............ls.s...h....l....P....F..h...l........h....L.......l....S...h..h..L.......L.......lh...S.Lh..+...H...h+....p...M....p....h....p....s....p....u....s....p.....D....P....S....s....c.A.H.....l..+...........A....l+....s....l....l....S....FL....l....L..a....h.l.....a...a......l....u....h..h....l..s..h..h....s....h....h....h..............p...p...........p...h...h..h....h..h...s...t...h...l.....h.h...h..a.PusH.S.hlL.I..h.uNsK.L+pshhphh....h.................................................	0	26	90	163
+5124	PF05297	Herpes_LMP1		Herpesvirus latent membrane protein 1 (LMP1)	Moxon SJ	anon	Pfam-B_5174 (release 7.7)	Family	This family consists of several latent membrane protein 1 or LMP1s mostly from Epstein-Barr virus. LMP1 of EBV is a 62-65 kDa plasma membrane protein possessing six membrane spanning regions, a short cytoplasmic N-terminus and a long cytoplasmic carboxy tail of 200 amino acids. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and has been associated with several cases of malignancies. EBV-like viruses in Cynomolgus monkeys (Macaca fascicularis) have been associated with high  lymphoma rates in immunosuppressed monkeys [1]	26.00	26.00	26.30	29.00	25.20	24.10	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.39	0.70	-5.53	2	1117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	10	3	0	569	0	128.40	64	101.97	CHANGED	ME+DLERGPPGP.RPPhGPPLSSSlGLALLLLLLALLFWLYIVMSsWTGGALLVLYSFALhLIIIILIIFI.RRDLLCPLGuLsLLLLMITLLLIALWNLHGQALYLGIVLFIFGCLLVLGLWIY.LEILWRLGATIWQLLAFhLAFFLslILLIIALYLQQNWWTLLVDLLWLLLFhAILIWMYYHG.RHoDEHHHDDSLPHPQQATsDSuHESDSNSNEGRHHLLVoGAGDGPPLCSQNLGAPGGGPDNGPQDPDNTDDNGPQDPDNTDDNGPQDPDNTDDNGPQDPDNTs...........DNGPHDPLPHNPSDSAGNDGGPPpLTEEVENKGGDRGPPSMTDGGGGcPHLPTLLLGTSGSGGDDDDPHGPVQLSYYD	.................................................................................................................................................................................................................................................................................................NLtA.uGGP.sNuPQDPDNTDDNGPQsPDNTDD.....NuP.....QsPDNTD.........DNuP......QsPDN...................D...NGPHDPlPpsP.sDuAGNsuGPPpLTEEVENK.GGDpGP...PsMTDG..........G..........G..........G.....c..........s.H............................................................	0	0	0	0
+5125	PF05298	Bombinin		Bombinin	Moxon SJ	anon	Pfam-B_5347 (release 7.7)	Family	This family consists of Bombinin and Maximin proteins from Bombina maxima (Chinese red belly toad). Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumour cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 have been found to be toxic to mice. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides [1].	21.40	21.40	21.50	21.40	20.30	18.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.79	0.71	-4.72	3	225	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	4	1	0	219	0	135.80	84	98.03	CHANGED	MNFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRGIGsKlLGGlKTAlKGulK-LAS+alNGKRTAE-HEVMKRLEAVMRDLDSLDHPEEASERETRGFNQEEIANLFTKKEKRILGPVLSLVGuALGGLIK	.....MNFKYIVAVSFLIAS.AYARSVpNDEQSLSQRDVLEE.ESLREIRGIGGKILuGlKTALKGAAKELApTYlptKRTAE-.HEVMKRLEAVMRDLDSLDaPEEAoERETRGFNQ-EIANLFTKKEKRILGPVLGLVGsALGGLlK....	1	0	0	0
+5126	PF05299	Peptidase_M61		M61 glycyl aminopeptidase	Studholme DJ	anon	Merops	Family	Glycyl aminopeptidase is an unusual peptidase in that it has a preference for substrates with an N-terminal glycine or alanine. These proteins are found in Bacteria and in Archaea.	21.30	21.30	21.70	21.60	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.59	0.71	-4.14	10	668	2012-10-03 04:41:15	2003-04-07 12:59:11	7	4	574	0	253	702	215	119.60	40	20.25	CHANGED	.tsthsLlAHEahHuWNsKhhRPA-Lhs.sacpsstssLLWlaEGpTpYaGhllssRoGlhopcpsLctLAtshuphhs.psGRtapolp-oohDs.hlphtRspshsshspppsYYocGtllh	..................tphLuLsSHEYFHsWNVKpl+Psshts....aDhspEsaTphLWhaEGhTSYYDcLhLhRuGllotcpYLchLupslsph.p..ssGRh.hQolu-SSa-A.WhKhY...+...tD.p.Nus...Ns.h.l.SYYsKGuLl.u.................................	0	76	165	215
+5127	PF05300	DUF737		Protein of unknown function (DUF737)	Moxon SJ	anon	Pfam-B_6933 (release 7.7)	Family	This family consists of several uncharacterised mammalian proteins of unknown function.	23.20	23.20	23.60	23.80	21.70	23.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.18	0.71	-4.33	21	182	2009-09-10 21:09:58	2003-04-07 12:59:11	6	3	44	0	74	148	0	140.90	33	75.13	CHANGED	hDEpEplpVl+GIRLSEsVlsRMKEsSsPsstpp..ss.ssus.............................................................sspppl++tssppht.uLcps+ttoppp.sth....hppt.hKRhcpEQhhlQ-EluRlhc+E+pAAp-pLspulLRE+susccERt+AppL.......ARpLE-+EtEL++pDsFYKEQLuRlEE+suEhYKlToEQaHcAAocsEu+hK	...........................DEp-plpllpGl+L.S-sVlpRM+-s.s..ss.t........................................................................................................................................................................................................................t..ttp.........pp..tt..pttp...............................cthtp............+...hppERtuu..........p....c.p....hptul.pc+hpspcEp.cuthh........A+pLpp+-t..lpp.-saY+EQltplEc+s.phY+.osppappAApchcsph+...............................................................	0	5	13	32
+5128	PF05301	Mec-17	DUF738; 	Touch receptor neuron protein Mec-17	Moxon SJ, Pollington JE	anon	Pfam-B_6943 (release 7.7)	Family	Mec-17 is the protein product of one of the 18 genes required for the development and function of the touch receptor neuron for gentle touch. Mec-17 is specifically required for maintaining the differentiation of the touch receptor [1]. This family is conserved to higher eukaryotes.	21.20	21.20	21.20	21.40	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.44	0.71	-4.17	5	201	2012-10-02 22:59:21	2003-04-07 12:59:11	6	2	118	0	116	212	3	110.50	48	33.85	CHANGED	SDc.QllYlhtDcsA..uu+utlhGLLKVGpKcLFLaDsptsppclEps.CILDFYVHEScQRsGpG+cLF-aMLpcEpsos+QCAlDRPSsKLLuFLuKHYGLc+sVPQuNNFVLaEGFFsc	.................................ppphhYlht-sps...ssp..Gsl..lGhLKV.....GhK+LFlh..............Dp.ptt.p.p.E.hc....sh..ClLDFY......lHEShQRpGhG+cLFpaMLpcEpl.p.P....p..plA.lDRPS.KLLtFLpKHYsLpph..........lP.Qs.NNFVlF-sFFt........................	0	50	61	93
+5129	PF05302	DUF720		Protein of unknown function (DUF720)	Moxon SJ	anon	Pfam-B_6980 (release 7.7)	Family	This family consists of several uncharacterised Chlamydia proteins of unknown function.	25.00	25.00	122.80	122.30	23.50	20.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.79	0.71	-4.38	6	105	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	34	0	13	42	0	127.40	45	76.02	CHANGED	lYFsI.shLh.SVtsspashuIhA..LQ-NTshQQphspEhhplphlpVPchpKpDs.........Nps.IQshQosNQpIoAsRQhIQppLSuApQpAQs.ppslNosss...QlLQsssALlpTLppl.olhANL	....hYFsI..hLhpSVtlsQpslulhAppLQ-NTstQQpLNpEpsplpassVPcstKpsp.........sps.IQsVQssNQsloAsRpsIQspLSuApQsuQlIpSslNTNsNIhQQlLQssoALlpThsplsSllANL	0	3	3	10
+5130	PF05303	DUF727		Protein of unknown function (DUF727)	Moxon SJ	anon	Pfam-B_7004 (release 7.7)	Family	This family consists of several uncharacterised eukaryotic proteins of unknown function.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.33	0.72	-4.26	10	194	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	117	1	136	179	0	97.50	31	24.97	CHANGED	shclEApAsVs-ltFuVspIsV.ScpLPpss-lsYlNVcThEuspYClELTppGaRlVSppaDplssc..............spltlsopYaETlYuLLDsISPsYREsFG...spLsQ+LccLp	.........................................................EA.uhlp-l.htVtph.l...Sp.L.pss...DlhYlNlpThEsppaClclo.p.pGa+l...su.p..hDphssc.............................p.s.tha-..TlhsLLsplSPta+...csFu...ptLhp+Lpt..........................................	0	46	70	111
+5131	PF05304	DUF728		Protein of unknown function (DUF728)	Moxon SJ	anon	Pfam-B_7223 (release 7.7)	Family	This family consists of several uncharacterised tobravirus proteins of unknown function.	25.00	25.00	117.50	117.10	18.10	17.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.51	0.72	-3.86	3	35	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	8	0	0	27	0	132.70	84	97.52	CHANGED	KCALssC..EVssQuNchTCSMKHANKYNRaLA-KauVKRKCECsNCGWFPAIpVpsDalEVYFCCGMKHLpKC+...............................ScNPKKccR....LNTPKRLFRDDVDFGLstLFu	....TCVLKGCVNEVTVLGHE.TCSIGHANKLRKQVADMVGVTRRCAENNCGWFVClIINDFTFDVYNCCGRSHLEKCRKRhEARNREIWKQIERlRAEcs.sTVKKS+NSKsSKKcFKEcc-FGTPKRFLRDDVPFGIDQLFA.	0	0	0	0
+5132	PF05305	DUF732		Protein of unknown function (DUF732)	Moxon SJ	anon	Pfam-B_7356 (release 7.7)	Family	This family consists of several uncharacterised Mycobacterium tuberculosis and leprae proteins of unknown function.	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.66	0.72	-3.93	65	1009	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	197	0	174	553	1	102.60	25	72.21	CHANGED	thhusssuhsu...........huhAAP.A......pA..........s..D.................s...sFLssLp.psGIs..as..ssstAlthG+tVCstlsp.Gt........shspllsplttp.ts.shs...........tpAuhFsshAhssYC....Pphhsth	..................................................................................hs...hhhhshhuh..........hshAuP..A..............pA.....s..................sh..D..................................s.....sFL...ssLp..pt..Gls.......as...........sssp..u...lshG+.tVCptl.ss..Gt.............shtpl......ss...t..l..tp....p.......s..shs..............ppAst.F.s....s.h.AhptY..C....Pphht..h.......................................	0	22	84	143
+5133	PF05306	DUF733		Protein of unknown function (DUF733)	Moxon SJ	anon	Pfam-B_7392 (release 7.7)	Family	This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.	25.00	25.00	37.60	37.60	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.95	0.72	-3.70	14	116	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	0	65	113	0	94.30	33	72.45	CHANGED	hpPsluYtLFhYRpELsR+pt..chhRlSpoKlhLTcELIupph.p...........sh.tpsSs--Lpt.............LsREl.....a+ccLp................cplc.Rhpchpthuhpp..tctp	...h.PoluYtLFhYRpELpR+ps..phhRlSpoKlpLTcpLIupsh.p..........................sl.ppCSs--Lps..................................LsREl.....FK+cLp..................cplc.Rh+chpphshpp.......................................	0	9	9	36
+5134	PF05307	Bundlin		Bundlin	Moxon SJ	anon	Pfam-B_6974 (release 7.7)	Family	This family consists of several bundlin proteins from E. coli. Bundlin is a type IV pilin protein that is the only known structural component of  enteropathogenic Escherichia coli bundle-forming pili (BFP). BFP play a role in virulence, antigenicity, autoaggregation, and localised adherence  to epithelial cells [1].	21.10	21.10	21.30	21.10	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.14	0.72	-4.12	2	81	2012-10-03 10:38:27	2003-04-07 12:59:11	6	2	47	3	1	100	12	90.00	68	53.31	CHANGED	MVSKIMNKKYEKGLSLIESAMVLALAATVTAGVMFYYQSASDSNKuQNAISEVMSATSAINGLYIGQTSYsGLNSNILLNTSAIPDNhKcstpshlT	..........MVSKIMNKK.YEKGLSLIESAMVLALAATVTAGVMF..YYQ..SASDSNKoQNAISEVMS..ATSAINGLYI...G...QT.S.YoG...LsSs...I...L.L..NT.S.AI.PDNY.KDTpNphl.........................	0	0	0	1
+5135	PF05308	Mito_fiss_reg	DUF729;	Mitochondrial fission regulator	Moxon SJ, Eberhardt R	anon	Pfam-B_6919 (release 7.7)	Family	In eukaryotes, this family of proteins induces mitochondrial fission [1,2].	26.30	26.30	26.30	26.30	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.76	0.70	-5.01	15	225	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	59	0	110	182	1	204.40	35	70.71	CHANGED	hplsl.WpsKPYGSoRSIVR+IGTNLPLtPCPRspFQll..Phsschssssssp...VPShADVuWlAsDEsEoasRlRs-lpspppp.+.sshhshc....RpsSlPsLppcEsphps.....tthss-sAlpKIoALEsELutLRAQIA+IVshQEtpssosush............sss.....o...ssohs.sssp..P....s..........PPPPPPsP.PssuLpsSsSsl............shhpER+p..ppsssscTlspspsKp....phPsML-lLKDMN+VKLR	.................................................................l.WpsKsaGus..RSlVR+IGopLsLh..CsRspFphh..........s.h...sphs.......ppss......VsohADlhWlAt...-.E...tc...s.sRh...R..s..p..h.....hsh.....h.p.hh.hp......Rp....SlPslptpc..p..h..............................thss..Alp+h.ssLpsELutLRuQIApIVshpptps.hsss.................................sssuh..ss.........s...................................ss...sl.pssSs.................................shhtEp+t..pptsts.ps....spspp......hssMhtlLKDhp..phKh..........................................................	0	16	23	52
+5136	PF05309	TraE		TraE protein	Moxon SJ	anon	Pfam-B_7677 (release 7.7)	Family	This family consists of several bacterial sex pilus assembly and synthesis proteins (TraE). Conjugal transfer of plasmids from donor to recipient  cells is a complex process in which a cell-to-cell contact plays a key role. Many genes encoded by self-transmissible plasmids are required for various processes of conjugation, including pilus formation, stabilisation of mating pairs, conjugative DNA metabolism, surface exclusion and regulation of transfer gene expression [1]. The exact function of the TraE protein is unknown.	22.40	22.40	24.30	24.10	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.87	0.71	-5.15	17	480	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	351	0	62	301	17	177.20	31	92.14	CHANGED	M-hphppsptphhhhth.hhsslhslhhhssllh...sathtscpcpsVhs.shstshslSssusDssYLc.hscshhhLpLNhoPcslDh.hpplLphscPuupspl+stLhcpsppl+ssslsstFhhsplcVsPpshpsclpGpL+TalGsptlss....-h+pYphpasacss.ltLssFtpl.ss...-p	.................................................................pt.p.hhh...hhhthl...lsl.l...hsNll..........shpht.s.cpc.s.sl.s.P...sh..s..t..shsVSp.s.sAstsYLpphul.hhtLhLNVoPpsVDtp+psLLphlpPuspsph+...shLtccAc..pIKs.csVsosFh....s.pl.c.s.s.pt.spVplpGh..h+.shl..us.up....s....ph.+.pYhl.hch.p.s.uhhhLtth.p.................................................................	0	17	35	51
+5137	PF05310	Tenui_NS3	Tenuivirus_NS3; 	Tenuivirus movement protein	Moxon SJ	anon	Pfam-B_7740 (release 7.7)	Family	This family of ssRNA negative-strand crop plant tenuivirus proteins appears to combine PV2 [1], NS2 [2], NS3, and PV3 proteins. Plant viruses encode specific proteins known as movement proteins (MPs) to control their spread through plasmodesmata (PD) in walls between cells as well as from leaf to leaf via vascular-dependent transport.  During this movement process, the virally encoded MPs interact with viral genomes for transport from the viral replication sites to the PDs in the walls of infected cells along the cytoskeleton and/or endoplasmic reticulum (ER) network. The virus is then thought to move through the PDs in the form of MP-associated ribonucleoprotein complexes or as virions [2]. The NS3 protein appears to function as an RNA silencing suppressor [3].	25.00	25.00	37.10	37.00	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.45	0.71	-4.39	9	133	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	12	4	0	134	0	172.50	48	84.62	CHANGED	LLhpsshhplll........................phscH..ua.plhptssstEsh.hhlpsuIWlLoap+shssphhhshsshsusasphhlphcPps...spsKCWhCc....hspssL.hhh.s..lpGF.hssE.YhVshK-Hsu........Ehhh.sshKshY+sspKhcHcYllsost.Pl.sppa	..................h..ppshoph.hshcDh....p.....aclhppRhsphccH..pa.pLhptssDt.sht.hltshIWlhuac+shs-chRhsphhhsuohschhhplKPcs...spTpCWhC+....hpp-sLshtl.s..VpGFsssuEhYhVslpDHsG........c.schssh+shY+ssuKh+HKYllsost.Pl.St+a..	0	0	0	0
+5138	PF05311	Baculo_PP31		Baculovirus 33KDa late protein (PP31)	Moxon SJ	anon	Pfam-B_7777 (release 7.7)	Family	Autographa californica nuclear polyhedrosis virus (AcMNPV) pp31 is a  nuclear phosphoprotein that accumulates in the virogenic stroma, which is the viral replication centre in the infected-cell nucleus, binds to DNA, and serves as a late expression factor [1].	25.00	25.00	28.20	27.10	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.01	0.70	-5.13	16	50	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	45	0	0	47	0	275.50	34	95.87	CHANGED	hssshsplhsKh..-susaNKssh-hlpssINhhEKKKIsYplhshPlhsD.............DKKssKRsKKhISNNKYILFNSWY..TK.RpssWPsSasMWNlhKspspspsFVplFDahEKlGKsIss+pusss.................spssssccpssht..hs.s-l.cEsNc+RsKLYsEFYclLspTFpsssAPusS.IYD.................-+LTRshlppulphFKs.lhhcl.......................ppsttstsussshssos.s.t.............RKRKps................htKpstttp+pppppt.ssshtMssDss-DoQ.MSp	.............................................s.ts.tplhsKh..EsSshNKoph-hltshINhhEKKKIsYplhshPshsD.............DK.KssK+sKK..lhoNNKYILFNSaY..TKl+pspWPsSpsMWNlhKspspspsFlcIFDa.h.EKlGKsIps+ppssus.................spssssccppsht.thshs-l.cEss-pRsKLYsEFYplLshTFpsss...A..PusS...IYD.................chLTRshlppuhptFKs.llhch..........................p.s..ssssshssoshstt.p...........RKRKps.................stpp.tttpppptpt..sss.sMssDpspDop.MS....................	0	0	0	0
+5140	PF05313	Pox_P21		Poxvirus P21 membrane protein	Moxon SJ	anon	Pfam-B_7803 (release 7.7)	Family	The P21 membrane protein of vaccinia virus, encoded by the A17L (or A18L) gene, has been reported to localise on the inner of the two membranes of the intracellular mature virus (IMV). It has also been shown that P21 acts as a membrane anchor for the externally located fusion protein P14 (A27L gene) [1]. 	20.70	20.70	20.70	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.38	0.71	-5.03	10	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	43	0	0	42	0	188.40	56	95.28	CHANGED	MSYLSYYNMF-DFsAGAGVpDpELFTcEEEcSFLPKcss..suta....h.......shcs.aP.sILhpNDI+oLlGLILFVLAITTsPlIAlIMIulAShLlPhPSLVIAYCLuhQIh...NsssssslGMSIlCVshSl.lTlhlsSlS...+sshTIoYIILulLFClYAFNlo+hst.pspsss.....tCs+thpuGsKhst-tP	..........MSYLpYYN.MlDDFSAGAGVhD+-LFTEEpQpSFhPKDGGhhps-Y..............ushNca..uIhpNNDVRoLLGLILFVLALhSPPLISllMIhIuShLLPL.sSLVIsYCLshQhh...+sGsuNTlGMSIVCllAAl.IhMAlNshT..sSphhshISYIILhILFhsYVhNIpRpchh+...Shslo.....sCs+sapAGNKhss-hP......................	0	0	0	0
+5141	PF05314	Baculo_ODV-E27		Baculovirus occlusion-derived virus envelope protein EC27	Moxon SJ	anon	Pfam-B_7811 (release 7.7)	Family	This family consists of several baculovirus occlusion-derived virus envelope proteins (EC27 or E27). The ODV-E27 protein has distinct functional characteristics compared to cellular and viral cyclins. Depending on the cdk protein, and perhaps other viral or cellular proteins yet to be described, the kinase-EC27 complex may have either cyclin B- or  D-like activity [1].	25.00	25.00	52.70	52.00	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.87	0.70	-5.34	19	59	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	56	0	0	53	0	272.50	40	97.46	CHANGED	h+s..ptsKl...RTVTEIlsucsKhpK-YDls-hshKN.sSLcSa-phplhLsluKYMAMlssLphoQsLltlF+s+sssccIlolVhsSLuFVHNRhsPhlspFs.cMcFVlscspchuIPGEPIlF.....pps-cpslhChlDRsoIl+hLE+phDsshphpp.sscc.pthKlhcshpsstp+++cs..t.shp.................tsshplsEs-sTQYlTLLlIhEHAYlHYalL+shshhpYhcoLlsHolhspc..sshtsshsNLLLSKF+FslE-.-p.+pssss......hs...lh	..........h.+s...sKl...RTVTEIlsucpKlpKcYDLu-F-hKNLsSLcSa-shcIKLhluKYMAMLssLphTQPLLplFRs+sss+cIsulVhuSLuFVHNRhpPhVspFst+MEFVls-stchsIPGEPIlF......ps-cp......s......llChlDRsSIl+hLp+pFDschplsppspcp.pth+lhKshssstp++pppp...t.....................sshplsEs-sTQYlTLLlIhEHAYlHYaIhKNashhpYscSLlDHolFssK.+sshssphsNLLLSKF+FslE-.-p.pppsss...thh...........................	0	0	0	0
+5142	PF05315	ICEA		ICEA Protein	Moxon SJ	anon	Pfam-B_2792 (release 7.7)	Family	This family consists of several ICEA proteins from Helicobacter pylori. Helicobacter pylori infection causes gastritis and peptic ulcer disease, and is classified as a definite carcinogen of gastric cancer. ICEA1 is  speculated to be associated with peptic ulcer disease [1].	19.00	19.00	21.10	20.70	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.65	0.70	-5.05	2	70	2012-10-05 18:28:12	2003-04-07 12:59:11	6	1	40	0	4	69	19	165.40	58	93.91	CHANGED	MphoKpELFLcLApPscpGlSRWVps.EFhGcYpsLpLGNGGSWCRpsSsLA+-ahlEFDKt.TsGNSIDtIRLNGaNpcphFpQ.I+pDIKshhpppsCsMhGVpGpSENTpIEIDHKDGRKsshRVSDlpTQph-DFQsLCKAsNDhKRQICKpCKEoshRasAppIsGNPYsFY.G-.pYs...GCVGCYQYDPlpYRKosscRIhsEuhphs...haphhYppcss	.......................................................hpRWlts.EF.sthptLt.hu....Nst.....sWhRtsSshA+ca.lEFDKtp.o.GNSID+IRLNGapscpsF..NQsIRpDIKsaYpppsCsMpGspGpSENTpIElDHK..DGRKsD.RVS....D..hss.Qph.-DFQsLCKAsNDpKRQICKcCKEoGhRasAppI...GN....YsFY-G.........t.pYD..............GCVGCYQYDPlpYRKpsscRIhpEuhphs..................................................	3	2	4	4
+5143	PF05316	VAR1	Yeast_VAR1; 	Mitochondrial ribosomal protein (VAR1)	Moxon SJ	anon	Pfam-B_7802 (release 7.7)	Family	This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal  proteins are encoded in the nucleus [1]. VAR1 along with 15S rRNA are  necessary for the formation of mature 37S subunits [2].	22.10	22.10	22.40	22.40	20.50	22.00	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.70	0.70	-5.85	5	28	2009-09-11 14:04:11	2003-04-07 12:59:11	7	3	26	0	9	39	0	290.00	34	79.83	CHANGED	pKhLLKNhLLKMNsNp.MN.shchsp+Ns.h.sKYlpEhNNKGNKLQ+lNNMNNWssQlYNYNKNNsINshlsDKLlNKLLYKLMslK..hINNN....sst..p+IIIsKPhaKHolNKlNI+FYY....YNsNhpshNNNNNpYYhNMINKLMNILN.....NpN.hNMN.NluNILShYYNKKVhIEsIKLpYlYNNN-IhNKYISlhDh-KYNNGLssc.Yp+lLNNhMPKhNspNIpMNYINNINNhNNlKY.NNMI..L......sSNN.l.........NIpNIYNshsINpIsM-LLMaKYLIGWSILaKGRLNKN..lSRosKspLLNGShsNKhYhKs...........................NINpNYKLNYIPNNHNIhNhNNVN..KNGKYNIKVKLNaI	......................................hK.hLh.hp.p..hp........p.............................s..sspL......QplNphNsap..hYpaNps..l..hh.sphhppLLhKhh..hh.....ss.............pIlhS+.shhpHshN+.lsI+FYY.......hp..s....p...s...Np.spYYhshhscl..hNhhs........Np..s.........ssLsNlLShYY.N.KcVpIpPI+LpY.YhNo-IhophI...h.shsp.h.s.psl.hp.a.+hLpshhPhhNsp......It....hsYlss..hs.s......hN...p.ph.NNhh........ssN........................slpNl.Y...pshslpp..hs....shLhhKYLsGholhhKG+h...pp..hsRo.p.h.lhpGoFpNhhh.hs...........................p.h.p.spYKLNYhssNhsh.s.s....p..lN..Ks...GKasIKlKLNhI...........................	0	2	6	8
+5144	PF05317	Thermopsin		Thermopsin	Moxon SJ	anon	Pfam-B_7819 (release 7.7)	Family	This family consists of several thermopsin proteins from archaebacteria. Thermopsin is a thermostable acid protease which is capable of hydrolysing the following bonds: Leu-Val, Leu-Tyr, Phe-Phe, Phe-Tyr, and Tyr-Thr. The specificity of thermopsin is therefore similar to that of pepsin, that is, it prefers large hydrophobic residues at both sides of the scissile bond [1].	25.00	25.00	52.70	36.10	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.80	0.70	-5.47	25	105	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	33	0	57	105	6	261.40	30	40.72	CHANGED	hhhpsh.ls..hhhhhstss........PhGlusYul.........shslpTspVlGhhNIsSLp..uastsstt.......shuASLQLNslLp.sshhs.tshtaWlQNVl.......hF.Tsssp...hsalDNlWNhTu.shusloss.l....pGpGtl..........p.YYsYus......shshshPhohhLhlNsohsst.ushltFGYsl.psusl........YDsVslsss.....s.tsA.hhlsGhshss.............tGl.hhDsELVaGGsGsGpsssapshsupLuLaY.hsu..ssapshsssYsaGhDTuEoutslp	.......................................................................................h.hs..........h.h.s.ss........PsGlssYGl............hslpTspVlGhlsIsslp....uh.shosst......sshuASLQLNshLp.hph.s.tphtaWlQNVl........F.ssssp...hphh-NlWNhTu.s.huslsss.l....pGpGhl.........ttt.YYsYss.........shhphshPhohhLhlss.ohs.st.sshlsFGYsh.psush......................hYDsVsl.ss........h.su.hhlsGh..s..hss.............hGh.hhDsELVhGGsGsG.p.sshhpph.suhLuLhY.h...ps....sshsshsshYsaG..hDTuEoussl.h.................	0	11	25	50
+5145	PF05318	Tombus_movement		Tombusvirus movement protein	Moxon SJ	anon	Pfam-B_4393 (release 7.7)	Family	This family consists of several Tombusvirus movement proteins. These proteins allow the virus to move from cell-to-cell and allow host-specific systemic spread [1]. 	21.30	21.30	21.50	21.40	18.30	21.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.69	0.72	-3.35	6	85	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	24	0	0	86	0	64.50	39	91.02	CHANGED	MDsp....ps.p.l.....tsGcpctuGp+GppK..s+RpVApcAl+....K..pussuosGGsWVhVADKlEVoIsFNF	......................s.p.........pV.......shstppthsus+GKpK....s++sVA+DAls....K..su.p.cussGusaVsVADK..IcV..sIpFNF........	0	0	0	0
+5147	PF05320	Pox_RNA_Pol_19		Poxvirus DNA-directed RNA polymerase 19 kDa subunit	Moxon SJ	anon	Pfam-B_6945 (release 7.7)	Family	This family contains several DNA-directed RNA polymerase 19 kDa polypeptides. The Poxvirus DNA-directed RNA polymerase (EC: 2.7.7.6)  catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.	25.00	25.00	211.80	211.60	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.95	0.71	-4.50	12	52	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	36	0	165.80	63	95.59	CHANGED	M--SsDI..sa.S---p..pY-E----...p.tEuhsooDlsshKpSsh+h.puhSpsh--t....pss.+plos+IpsIK+RYTRRISLFElTGIlAESYNLLQRGRLPLls-LSD-Th.+pslL+lllcEIEEGsCPIVIEKNGELLSlsDFDpcGLpaHLDYIhsIWKpQpRh	....MADoDDII.DY...-SDD.s..EYE---E-..-E-uESLETSDlss..pSuYKI.ESASopIEDA....poshK+lus+ISALK+RYTRRISLFEIsGIIAESYNLLQRGRLPLVS-hSDETh.KQNhLHVlIpEIEEGoCPIVIEKNGELLSVsDFDK-GLKaHLDYIIcIWKhQpRY	0	0	0	0
+5148	PF05321	HHA		Haemolysin expression modulating protein	Moxon SJ	anon	Pfam-B_7025 (release 7.7)	Family	This family consists of haemolysin expression modulating protein (HHA) homologues. YmoA and Hha are highly similar bacterial proteins  downregulating gene expression in Yersinia enterocolitica and Escherichia  coli, respectively.	25.00	25.00	25.60	25.50	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.76	0.72	-3.83	14	1466	2009-09-11 00:35:18	2003-04-07 12:59:11	6	1	560	3	79	307	5	56.20	58	82.15	CHANGED	hphR+Cooh-TLEKlh-+p+.p..Lsss.EhpsFpuAADHRLAELsM.sKLYD..KlPssVWp	......h+hR+hpol-oLE+lh-+s+Yp..LoDs.....ELtsFYSAADHRhAELsh.sKLYD..+lPpSVW+............	0	4	16	48
+5149	PF05322	NinE	NINE; 	NINE Protein	Moxon SJ	anon	Pfam-B_7029 (release 7.7)	Family	This family consists of NINE proteins from several bacteriophages and from E. coli.	25.00	25.00	30.30	30.20	23.80	23.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.15	0.72	-4.23	3	157	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	136	0	0	53	0	58.20	92	95.15	CHANGED	MRRQRRSITDIICENCKYLPTKRSRNKhKPIPpESpVKTFsYluuLhDS+Ws...RaCs..R+TR	.......MtRQRRSITDIICENCKYLPTKRSRNKRKPIPKESDVKTFNYTAHLWDIRWL...RHRA..RK........	0	0	0	0
+5150	PF05323	Pox_A21		Poxvirus A21 Protein	Moxon SJ	anon	Pfam-B_7034 (release 7.7)	Family	This family consists of several poxvirus A21 proteins.	25.00	25.00	29.10	28.90	18.50	17.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.51	0.72	-3.67	11	60	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	46	0	0	41	0	112.80	61	97.71	CHANGED	MIoLFLlLCYFILIFNIIVPsIuEKLRpEacAas+Y+pl.ppcalCVDspLhsYsFssoGlpAphhlDsss.sPLPCS+hspscst..chlsC-..stsslhch+csCu+AYh-LFh	MITLFLILCYFILIFNIIVPAISEKMRRE+AAYlsYK+L.sKsFICVDDRLFSYsFTTSGIKAKhAVDscs.lPIPCS+IN-VNsN...csLhCD..pDcsDIs.sFsRSChRAYuDLFF.	0	0	0	0
+5151	PF05324	Sperm_Ag_HE2		Sperm antigen HE2	Moxon SJ	anon	Pfam-B_7044 (release 7.7)	Family	This family consists of several variants of the human and chimpanzee sperm  antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a  family of androgen-dependent, epididymis-specific secretory proteins.The  EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages.  The translated putative protein variants differ significantly from each other. Some of these putative proteins have  similarity to beta-defensins, a family of antimicrobial peptides [1].	20.10	20.10	20.80	22.90	18.20	18.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.28	0.72	-4.06	4	65	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	19	0	13	61	0	68.50	59	59.33	CHANGED	KphLhP.hsSLLLVALLFPG.SpApplNHpsTEuPRc.pEEusGQGsNcSpLLHHpVKRh.llPRpPPY.Es-P	..............+QRLLP.hsSLLLVALLFP.G.SpARHVNHSuTEu.pEL...REtAsGQGTNtSQLL+HsVKRt.l.PRTP.Y.t................	0	2	2	2
+5152	PF05325	DUF730		Protein of unknown function (DUF730)	Moxon SJ	anon	Pfam-B_7197 (release 7.7)	Family	This family consists of several uncharacterised Arabidopsis thaliana proteins of unknown function.	27.20	27.20	27.60	172.60	26.70	27.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.63	0.71	-4.31	3	10	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1	0	0	10	0	117.10	82	83.76	CHANGED	MEIRMRMRYGENRRRDKGVPIECDCNAKVVVATS+DPVTSGKLYFSCPYEISDGPGRGCGFKRWWTVALCDEFDMIKEEpsEMKKDLEAANK+VEuQsEKIFLMEKKFETLEKKYESlNKYS	.MEIRMRTRYGENRRRDKGVPIECDCNAKVVVATSLDPVTTGKLFFSCPYEISDGPGpGCGFKRWWTVALCDEFDMIKEEToEMKKDLEAANKRVESQsEKIFLMEKKFETLEKKYESLNKYL......	0	0	0	0
+5153	PF05326	SVA		Seminal vesicle autoantigen (SVA)	Moxon SJ	anon	Pfam-B_7065 (release 7.7)	Family	This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory glycoprotein suppresses the motility of spermatozoa by interacting with phospholipid. PIP, has several known functions. In saliva, this protein plays a role in host defence by binding to microorganisms such as Streptococcus. PIP is an aspartyl proteinase and it acts as a factor capable of suppressing T-cell apoptosis through its interaction with CD4 [1].	23.10	23.10	23.10	23.20	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.71	0.71	-4.34	11	63	2012-10-03 02:52:13	2003-04-07 12:59:11	6	1	32	1	27	173	0	111.50	44	84.82	CHANGED	sLQhLapsossThLLlLCLpLtss....cuQ-N..pppslhhshclssss....spspEsTVpLsVpTpl+ECMVlKsYLhSNhslc.GuFNYpaTuCLCsp.PpsFaWDlhsscTsplsssVDll+EhsICPDD	......................thhhpsssshhhLllhL.Lths....puQ-s..sR+hlhhshplPpos....cts-ElTssLpVpT-L+ECMV.lKsY..L..h..S..s..h..s..l.-...GuF.N.Y...p..YT.uCLCs.s.P+TFYWDhh..ssc..T....spIsuVlD..llpEhsICP-D.......................	0	1	1	6
+5154	PF05327	RRN3		RNA polymerase I specific transcription initiation factor RRN3	Moxon SJ	anon	Pfam-B_7041 (release 7.7)	Family	This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required  for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae [1].	20.60	20.60	23.90	21.60	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	564	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.94	0.70	-6.40	33	404	2009-01-15 18:05:59	2003-04-07 12:59:11	6	12	278	2	283	410	5	426.80	23	78.29	CHANGED	sstpsschotphhcp.....hV+cALpphp................pG...-sstacplpphh..........tshptt...-s.s.sphpplLpsLtssVstLDps.sssLVp.ulLsh.pWh.s+spsh.........lctYlpFLssL.............suup.spalstllshLlspFs..spt...ssp.........t....p..phhpphHthLppllchlPsusshL.shLsppFPat.scopcshhs.YlpNLL+ltpYs...spLptclhpLlh-+llclDV..........phps-h--l........-D-ppcth.tt.t.pstppth.-.-sss...............ttp.....s.ps-sp.....................................spphpsl+phsp+LDsllshlhsahcs............shsssphsp...............................s.slFcsLlshFpshILPTapo+asQFLlFahsphpsphs-.pFlspLhclsh........s.sspss.h..R.uAssYLuSalARA+alstpplphlhshLssaLspYltpp-sss...............tssshcc.atsFYussQAlhYlFCFRa+sLh.........................sps.........hsahsslcph.Lp+slhSKLNPLKhCsPsVVstFA+lup+hsl..sYsaoI..lEpNpR...................t+lsphhuts..................t....p.........L-uaFPFDPahL.pS+ch..lcs.YlpW..ptlsspp	...................................................................................................................t....................h..hh.t........................p.........ht.hh..h.................................t.......h..hl..h.t.h..lp....t...ht.l...lp..lhph..W....th.s..th...........hp..aht..hlh.L.................sss..s.aht.shthlhpthh............................................................t.hH..hlp.lh.phhP.s...hl.sh...l....ptaPhh.....ppstt......h....Yhp.Nlltl..hh...stlt..tlhthl...hp+hlplDl......................pht.hpph..........-ct...t.................................t.....p..pt.t..................................................................................................................t..t.hp.hhpplD.hh.hhhphhp...............h...p...t.................................................................................................................................................hap.LhthFpphlLss.atopasQa..lhFahsph.p.................t...............hhc...tFhthLhp.hh..........................................s...sp...ss.h.....R.sussYluSalARuthls...hl...............h.hhphLhpah...pt..a.htp.ptts................................................................ssht.h..at.FYushQAlhYhhsFRhcplh.....................................................................pt............hth..pl.p......hpphlh..s..p..lNP..L+hC..slst.F...utlspthth....ha.hhsl..lEps.pp..........................................l..hhs.......................................................................L-saFPFDPh.L..st.p.h..lt..a..ap...................................................................................................	0	116	178	239
+5155	PF05328	CybS		CybS	Moxon SJ	anon	Pfam-B_7102 (release 7.7)	Family	This family consists of several eukaryotic succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) proteins. SDHD encodes the small subunit (cybS) of cytochrome b in succinate-ubiquinone oxidoreductase (mitochondrial complex II).  Mitochondrial complex II is involved in the Krebs cycle and in the aerobic electron transport chain. It contains four proteins. The catalytic core consists of a flavoprotein and an iron-sulfur protein; these proteins are anchored to the mitochondrial inner membrane by the large subunit of cytochrome b (cybL) and cybS, which together comprise the heme-protein cytochrome b. Mutations in the SDHD gene can lead to hereditary paraganglioma, characterised by the development of benign, vascularised tumours in the head and neck [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.54	0.71	-4.54	48	384	2012-10-03 07:11:12	2003-04-07 12:59:11	7	5	272	30	229	486	257	123.80	29	70.69	CHANGED	hsphphlPp....Pthl.GolN..-sh...PtssthcGShHWshERlluluLlPLssssahs.ss.........sslhDusLussllhHsHhGFpusIhDYlsp+haG.thtphAhhlLthuoslshhGlY.hEop-s.GlscslpplWp	...................................................................h...........................t.......st..ssttpuShHWshERllusuL...lP..Lhs...s..sahs..............................sss...hDshL...u...s....s.L...l....l...HsHh...Ghp.uslhDYl.....phhs...thp....phu.h.h.hL.h.h.h.o.sh.shhGla.hpp......p-s.GlscslpplWp.......................................	2	70	121	188
+5158	PF05331	DUF742		Protein of unknown function (DUF742)	Moxon SJ	anon	Pfam-B_3675 (release 7.7)	Family	This family consists of several uncharacterised Streptomyces proteins as well as one from Mycobacterium tuberculosis. The function of these proteins is unknown.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.37	0.71	-4.48	14	710	2012-10-04 14:01:12	2003-04-07 12:59:11	6	6	167	0	269	736	6	113.50	37	80.96	CHANGED	scssshVRPYslTsGRocsst...slsLholVsAtsstP.................sshtPEctpILcLCps...shoVAElAAtLcLPluVV+lLLuDLh-sGtlss+tPhs......sphPDpsLLccVlsGLRpL	....................................................................................................................s..tsshVRPYslTu.GR...Tcssh.........sLsL.sl.Vssp.s.s.ss.....t..t..........................................hsht.sE..+ppIl.p..LCpp....shS...VAEluApLcLPlGVsRVLluD.LsssGhlpl.+p.ssss..............s.....t..........ts..D.....h..sLLccVLsGLRpL..............................	0	76	213	260
+5159	PF05332	DUF743		Protein of unknown function (DUF743)	Moxon SJ	anon	Pfam-B_4046 (release 7.7)	Family	This family consists of several uncharacterised Calicivirus proteins of unknown function.	27.70	27.70	27.70	120.10	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.30	0.72	-4.09	4	42	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	18	0	0	36	0	104.60	56	96.36	CHANGED	NhGLsLlsolANAhhEGp+l-LsupuLuhpp+hh-sEpcaNhsRLsF-...........KppFppsh-L+lpGslhRhpthRAAGaRlNPYSNGpQlahDEsttApLpSYhsFYKs	.NSILGLIDTVTNTIGKAQQIELDKsALGQQR-LALpRhsLDRQALsNQ...........VEQFNKlLEQRVpGPlQSVRLARAAGFRVDPYS.sNQ.aaD-thsA.hhSY+shaKs.	0	0	0	0
+5161	PF05334	DUF719		Protein of unknown function (DUF719)	Moxon SJ	anon	Pfam-B_7667 (release 7.7)	Family	This family consists of several eukaryotic proteins of unknown function.	20.80	20.80	20.90	22.30	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.36	0.71	-4.25	6	168	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	81	0	95	154	0	158.60	48	33.17	CHANGED	S..puu.WG....hWGuhupSlLSoAotslATl...hTpVppthpsslGlPsPpELutpsstEcAEpstpssspt-s......-sspGots.....hssuFG.hstlsssVpshGppVloGGLDsLEhIGKKTMslLtEsDPGhhpp+pLh....N+sssLSQVLREAKc+.EchpcshpQlphEppKt..hHathLFD-YpGL	.......................................su..Wu....hWG..oW.G.K.S.lLSoAoATVups..............los.VhEK...A....t..soLtI.ss....sph.up.pst...ts.cp....t.............................................ptspssss............su.u.sh...G.hh.......Ssl.o..ssV...........Q.sT..GK....oV.loGGLDALEFIGKK..TMsVlAEuDPGFK+TKsLM............pRssoLSQlLREAKEK.Ec.pphup...plshEps......sHYGhLFDEaQGL.................	0	23	29	56
+5162	PF05335	DUF745		Protein of unknown function (DUF745)	Moxon SJ	anon	Pfam-B_5169 (release 7.7)	Family	This family consists of several uncharacterised Drosophila melanogaster proteins of unknown function.	22.40	22.40	22.40	22.60	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.37	0.71	-4.77	14	190	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	39	0	120	201	4	174.00	35	58.26	CHANGED	sshs...htsss+pKuSsIApKAAp-AKsAsDuQsuAuctAupplKppLA-KAhtAA+AAEAALAGKQQll-QLEpElpEActVVpE.ppuLpsopssApuAttssppAppplpsLpshlcsApsslssh-psAssAQpElsEKsQLL-AA+pRV-hLt+QlpsA+tDa-pTKpAAhKAACAApEA+Q+A	.........tttt.......hpspptussIAppAAppAKuAsssQ.uAuptAA.psKtpLAp+.AhpAApAApA.sLsGKptllcpLcpchpEActsVpcEpspLppu.pssspuAtp.......ssppAppp....lpsLpshlpsApsshsssppsAssApp-Lup.....+sphlts.A+pRl-tLpcQltsA+tDappT+pAAhKAssAA.EAppps.............................	0	34	39	84
+5163	PF05336	DUF718		Domain of unknown function (DUF718)	Moxon SJ	anon	Pfam-B_7227 (release 7.7)	Domain	This family consists of several uncharacterised bacterial proteins of unknown function.	23.40	23.40	23.70	23.40	22.70	23.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.32	0.72	-4.23	61	1431	2012-10-02 00:20:33	2003-04-07 12:59:11	8	7	1252	8	330	844	242	104.20	38	92.26	CHANGED	pRhuahhpLc..Psph-EYc+pHsp..l...WPEllptL+psGlpsYSIaLc.tppshLFuhhEhps.....-tshs...thupsslsp+WWshMuslhc..s.ssspPsp..........ssLpcVF+Lc	.........................RhAalhplp..P-..t..hcEYp+RHst.....l....WPEl...ps...s...L..+p..p.GspsYuIaLc..pp..........p.....s.....hLFuhlEhcs................Et.c..h..s.....tl.A..so....s....lsQ+WWcaMs....clh....ssP.D..s.......o....Pss.................spLpEVFaL.............................	0	100	218	277
+5164	PF05337	CSF-1		Macrophage colony stimulating factor-1 (CSF-1)	Moxon SJ	anon	Pfam-B_7649 (release 7.7)	Family	Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth  factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic  lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility [1] and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption [2].	25.00	25.00	35.40	43.70	24.20	23.60	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.66	0.70	-5.06	9	118	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	29	2	35	134	0	226.10	38	95.29	CHANGED	hTstGuut.sPSsshh..Gsc.lLssLLsoNhlsEEsStcsS............ahlGsGplps.pph.cuphpsSstlshphhDQc.lD.....lpcAaLhs.s.McsThchpsNTPpts..........chsSshscDapE.spAplpTh+.p........................PLt.LEthKs.........................shp-p+sLhEh-hs.hScssspshA+hsShs.........LhspGpspQc.uSssPQhPt.VFhlLsPSlILVLLsVGGLLFYph+hRSHpDPQtsDSSstpPEsSsL.TQD.DRQhELPV	......................................t.tPsssh...G...lLsshLsop..hhEEsStpsS............ph.GsGplQs..p.th.ss.hpsSs.lshphhsQp.hc.....lppshL.h.s.hcsThphpspTPptp............chtSs..hh+DhpE.spsplpohh.p........................PLt.LEth+.shp-p+s.h....-h-hs.........hScsssp......shAchsS.s.........Lhspup.ppc.uSssPp.s......LsPS....hhsluGLha............p-spts-us...Pp.t.p.PL.T...D.s..pthphPs..........................................................	0	2	2	7
+5165	PF05338	DUF717		Protein of unknown function (DUF717)	Moxon SJ	anon	Pfam-B_7144 (release 7.7)	Family	This family consists of several herpesvirus proteins of unknown function.	21.30	21.30	26.00	65.80	21.10	20.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.65	0.72	-4.02	11	20	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	18	0	0	18	0	56.00	39	70.93	CHANGED	sploEpDFppChpFFs+Pl.pllspsupuLsslchscossQpl-pLsLlLDLlGTE	.sploEpDFp-CtpFFs+PLpcllsssucuLsslclscSssQplEpLsLLLDLlGTE	0	0	0	0
+5166	PF05339	DUF739		Protein of unknown function (DUF739)	Moxon SJ	anon	Pfam-B_7696 (release 7.7)	Family	This family contains several bacteriophage proteins. Some of the proteins in this family have been labeled putative cro repressor proteins.	19.50	14.00	19.60	14.40	19.20	13.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.91	0.71	-4.37	11	78	2012-10-04 14:01:12	2003-04-07 12:59:11	6	1	77	2	9	39	3	67.70	43	73.40	CHANGED	hsaD..........YScLpG+I...............lE+YGo..............................pasFApAls..lSE+olS.hKLNsKl..................................sWpss-ItKAh-.lLulsp-.............clspYFFph	...............................hsh..............atpLtG.l...............lEKYGo....................................pYsFAhAht...LSERolS.LKLNsKl...................................W..s...tshp.hlth..p......................h..................................	2	4	9	9
+5167	PF05340	DUF740		Protein of unknown function (DUF740)	Moxon SJ	anon	Pfam-B_7873 (release 7.7)	Family	This family consists of several uncharacterised plant proteins of unknown function.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	603	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.33	0.70	-6.15	6	176	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	19	0	119	155	0	210.00	18	72.48	CHANGED	ssspssp.+RhSTSCcRHP-E+.FTGFCsSCLpERLSsL-ts.......SSSuptPso.Sssul+ulFt.s.sss..............u.hPELRRsKSFSs.+...........ssAusSsu.EPQRRSCDVRs.+soLhsLF.pDD-cplsSs......sss..p.....RcshVs-.lhEE-pEh..EcD--...t................Estcll-Epspc.................hp-EEtKsMKDa.hDL-Spp.+K.ssKc....utSFasAASVFSKKLQKW+pKQKhKKcc..sGsuuutss.....................u-huhGRRSCDTDP..............RFSlDuGRlShDDstaSFDEPRASWDGpLIG+oh......sP.....hPoMhSVlEDuP......lpRuDhph......Psss.lp.pcu-pD..h..PGGSsQTRDYYhD.sSSRRR+SLDR.SsShR+hu...ltElDElKsluNucsSs...........hsppppLRDpsh.s.sNhcsEotE.su.............p.sust.cKKs+RWuK.WsIaGLIaRKsss+.......cp-p.p+hs.ushVERSLSESW.s-LRsst......GsuPKMlR.........sNSslShRS..SG.pGG.............................G.puppp.phlpp+sKsupYSs.cssENGMLRFYLTPh+uptpuuGu	..................................................t..............C.hHP.p..hsGhCs.CLp-RL..lt.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s.........................................................................................	0	11	65	90
+5168	PF05341	DUF708		Protein of unknown function (DUF708)	Moxon SJ	anon	Pfam-B_7259 (release 7.7)	Family	This family consists of several uncharacterised nucleopolyhedrovirus proteins of unknown function.	21.30	21.30	21.50	41.70	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.33	0.72	-4.25	24	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	55	0	0	53	0	105.70	44	78.30	CHANGED	phpWpllss......shlEVsPc-REpAWKDLll.sLpsoPp..oaRTtlp+AshEpFDYKpPIhY-lKp+pLhlss-plhpALs..hPp.sshsshslsshplhhs....FIhslLl	...lRWp..lLNs......DclEVsPEcREpAW+-LlIsllpsoPt..TaRThlpKAshENFDYppPIlYslKsKpLllss...EplppALN..RPt.tshsshNlsshplhLs..FIhslLL.....	0	0	0	0
+5169	PF05342	Peptidase_M26_N	Peptidase_M26; 	M26 IgA1-specific Metallo-endopeptidase N-terminal region	Studholme DJ	anon	Merops	Family	These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with Pfam:PF00746, they may be attached to the cell wall.	25.10	25.10	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.59	0.70	-5.40	19	698	2009-01-15 18:05:59	2003-04-07 12:59:11	9	66	278	0	17	423	8	240.30	39	13.51	CHANGED	-pl-hhp-YThsTp......shs.s-sspsct.p-p.......hp.s.KKlEL+NlsslcLhp..-NGp.ppps.LsphPs..ssssYalKVpSss.K-shLPVsSIEEssc-GpslYKlTApsscLlQ.ct-sphp-sasaYltKttsc-sslYhsFpsLVcAMppN.sGTa+LGAsLsAspVphssss+SYlpGpFoGpLlGsp-GKcYAIaNLc+PLFssl.puuolcclsLKsVNIstp.....sclAolAppspsuopIcNV+VsG	.......................................plchhptYplpTph.....sasp..upus...c.o.pt.c-.p...........hplshKKl..El+..NIssspLhp.........-sGp.p..phshL...sphPs..sspphalKVpSps.KsshLsVsS.IEEssh-GpplYKlsApApcLlQ..ctssph.pppYsaYlp.K..t.sc.-ssVYhsFppLVcAMpssPsGTF+LGAslsAspV..ssss+S..Y..lpspFpGpLh.o.s-G.KpYuIaNL...c.......+P.......LFssl.pu......uTVcslsLcsVsIsh...........-slAs.lApphpssopIcNV+VsG.............................................	0	2	4	8
+5170	PF05343	Peptidase_M42		M42 glutamyl aminopeptidase	Studholme DJ	anon	Merops	Family	These peptidases are found in Archaea and Bacteria. The example in Lactococcus lactis, PepA, aids growth on milk [1].     Pyrococcus horikoshii contain a thermostable de-blocking  aminopeptidase member of this family used commercially for N-terminal protein sequencing [2].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.74	0.70	-5.64	69	4278	2012-10-02 19:46:12	2003-04-07 12:59:11	9	6	2184	65	699	4495	777	284.40	30	81.45	CHANGED	Gsllup.ppG...su..+lhluAHMDElGhMVppIccsGhL+hsslGGhsspsl.up+lplhscpG...l.GVlGstsP..Hlhc.stccppshp....hc-lhIDlGsps+--AcchGlplG-hlsh...cschthlssph.lhu+AhDsRhGsslll-ll+pLpcpph...sslahsuoVQEEVGLRGApsustplpP-hslAlDsssu.uDsssssctp.....lGpGsslphhDss.....hlhc.plpchLh-hAccpsIPhQhc.hhssGGTDAuuhphs.ttGlPouslulssRYhHS.sEhhchcDlpsshcL	.....................................................................................................................................................Gulhsp..h....pu....tpsu....+lhlsAHhDElGaMVppI....c....c.s....G..hlchps..l...G..G.....a.spsh.upplplpTcp....G....plsG.ll..u..s..hss.........Hhh.........p..s.........t.........tc.........p...p........p.....hp..-lhlDl...Gs..............p...o...c.-.E...s.c.p.h.GIcsG..D.h.....ls.........csp.h...t.h........h...s...sst...lhuK.A.....h.Ds.RhGss.hllclL..c.p.L.p..s..p..p..ls...........hsla.hs.soVpEE...V.G....l............RG....A....p........s....u......s....p....p.......................l......p.P...D......l...................h....l.u...l......Dsuss....sD...s......s......ss.php........hG.pGshl.t.h.h..Dss..........hlhp.p.l..p.c.a.l.h.s.l.A.....c.....c..p.....sIPa.........Q...h.........p....h....h............s...t...........G...G..TD.A...u...u....h...p.h.s...s..sGlP...s...s.slGl...ss..RYhHo....hphhchcDhtsshpL....................................................................................................	0	268	469	596
+5171	PF05344	DUF746		Domain of Unknown Function (DUF746)	Yeats C, Eberhardt R	anon	Yeats C	Family	This is a short conserved region found in some transposons. Structural modelling suggests this domain may bind nucleic acids [1].	23.70	23.70	23.80	31.10	23.00	23.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.76	0.72	-4.44	10	78	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	34	0	16	77	0	63.60	41	34.53	CHANGED	c+hcthIRhLSpPlSlh-AA-tlGsscssltchVchFRpalLpLDPSGpaEsRlRLGsRPspsss	......c+hcLFlphLS.PlSshpAuctlGot.ssltchlphaRpalLpLDPSGphEtRlRLGs+ssphss......	0	4	8	12
+5172	PF05345	He_PIG		Putative Ig domain	Yeats C	anon	Yeats C	Family	This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to  (Pfam:PF02494) and (Pfam:PF00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (Pfam:PF02639) and  (Pfam:PF02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei ([1]).	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.37	0.72	-3.94	108	2176	2012-10-03 16:25:20	2003-04-07 12:59:11	7	369	532	0	988	2359	2162	49.40	32	9.08	CHANGED	oaoh....................ssssLPsGLol...........sssoGsloGT....ssss...............G.sashslssossss	...................................................sh.....................ssuLP..sGLoh...........................ssu....TGslSGT.........Poss....................................G.sa.s.lsVosTDss......................................................	0	490	754	893
+5173	PF05346	DUF747		Eukaryotic membrane protein family	Wood V, Bateman A, Murphy T, Mistry J	anon	Pfam-B_13582 (release 7.8)	Family	This family is a family of eukaryotic membrane proteins.  It was previously annotated as including a putative receptor for human cytomegalovirus gH [1] but this has has since been disputed [2]. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.	25.00	25.00	27.70	25.10	24.10	23.60	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.26	0.70	-5.39	36	347	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	271	0	241	343	1	312.30	35	47.39	CHANGED	p.....ptlsttphsDllphhlllhsshlLp..........hl.DsS+hYHhIRuQusIKLYllaNlLElsD+LhsShGpDll-sLhpssh.........................................................................................................................................................................................................ttpthhchhshahlulhYlshHuhlLlhQsloLNVAlNSasNuLLoLLlSNpFsElKuoVF......KKF-+EsLFQlotuDllERFpLhlhLhll..ulRNhhph....................................h.tuap.....................tlhushlhVluSElh.VDWlKHuaIsKFNcl+splYpcahplLs.....tDhh............................t.hsts.hls....+RlGhsshshsslhl+hhh.hhphhh....................................................................................................hthlshhhlhlhsahhLlhhKllLuhhllpaupphhp.phc	...................................................................htstphsDllp.hhl.llhsh.hhh...........hl.DhSh.hYHhIR..uQ.usIKLYllaNhLEluD+LhuuhGQDll-sLa.ptt.............................................................................................................................................................................................................................................................................................................................................................................................ptp...p...thht.h..hhhh..ul....hY...s....hhHuh....hlhhQsh......oLNVAhN..Sa.s.............puLLTlhhSNpFsEIKu...........oVFKKF-KpNL...............F.Qlo.s....uDlhERFplhlhLhll..shRNh.ph.....................................................p.ah........................lhsshhhVlsoEhhVDhl.............KHAaIsKFNpI.p.sslYpcaht.Ls.........hDhh..............................................................s....sthsptls....RRhGh.slPlusLhlRsh.hpshp.............................................................................................................hhh.hhhhhhhah..hLlhhKll.uhhLlthupph.t.............................................................................................	0	83	142	206
+5174	PF05347	Complex1_LYR		Complex 1 protein (LYR family)	Wood V, Bateman A	anon	Pfam-B_15215 (release 7.8)	Family	Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex.  In Saccharomyces cerevisiae, the Isd11 protein (Swiss:Q6Q560) has been shown to play a role in Fe/S cluster biogenesis in mitochondria [1][2]. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.93	0.72	-4.17	246	1703	2012-10-01 20:54:40	2003-04-07 12:59:11	10	21	313	0	1190	2012	12	60.50	22	42.65	CHANGED	pp..lLpLYRplLR..pu.pp......hsshs..........+phh...ppplRspF+c..s+s...hp.-.ppl.....pth......lppupcpLph	...................pllpLYRphLR......ts..pp........................hst.ts............pphh.........ppt...lR..ppFcp....s+s......hs..-sppI..................pth..........................lppup..h.....................................................	0	377	651	958
+5175	PF05348	UMP1		Proteasome maturation factor UMP1	Wood V, Bateman A	anon	Pfam-B_18845 (release 7.8)	Family	UMP1 is a short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. UMP1 is required for the correct assembly and enzymatic activation of the proteasome. UMP1 seems to be degraded by the proteasome upon its formation	21.50	21.50	22.20	21.50	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.42	0.71	-4.19	7	345	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	278	0	233	323	2	122.10	29	80.51	CHANGED	shpshthtlsuhht.hcshphGhhsshsplhssHPLcss.cN.hptpQcphphphlRph.GlthPLKhsMEpplhpphpR.P.hlsSuphth-lLsGp.-slsFEDhhNsPppuEhhh...p.HthhEhpLGl	..........................................................................s................c......t....G...........s..ht....s.p..l.h....s..s..HPLEtp.ps.aptspcphphptlRplaGhttPl+htMEhc.llp.......p........sp.+.hP..............h.L...s.....S.......S..........s..l..thDlLp..Gp--slsaED.....lh.....s..ss.p..tp..-...ht............p.Ht.hEh+L....................	0	71	119	180
+5176	PF05349	GATA-N		GATA-type transcription activator, N-terminal 	Finn RD	anon	DOMO_DM03585	Family	GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain  congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical  zinc finger. This family represents the N-terminal domain of the family of  GATA transcription activators.	20.30	20.30	20.60	20.30	19.50	20.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.77	0.71	-4.10	16	190	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	48	0	70	154	0	155.00	39	41.19	CHANGED	MYQo....LAluuspG.s..uYs.ss.GuFlHS.........s..AoSPVYVPToR.VsoMl.sLP.....YLQsstsuppu.................ps..huuHsuWuQs.uu-os.uassuS................sHsPsu.......Fsau.pSPPhuuuuu....RDsu.............YpusLhhss.u...R.-QYush..sRsluGSYsSs......YsAYhoP-lu...s.SW......suGPFDuSV.LHuLQuRs.ushsu.R+ssh..-hL	..................................................................................MYQo....LAhsus...u.s....uYt.ss...usF.hHu...........s..usSPVYVPosR.Vsuhh.sLs.....Y.Lpsstsu.ts.....................ts...supssWs.Qs.us-us.sass.....................ssst.......F.sas...os.....s..hss.usu......R-su...............apu...sh.....u....R.-QYut....RshsGoYsos..........Ys.....s.Yhu...s.slu...s.uW.......suGPF-.usV.LHuLtuRs.ss.ss.Rtssh...............................................................	1	4	12	30
+5177	PF05350	GSK-3_bind		Glycogen synthase kinase-3 binding	Finn RD	anon	Pfam-B_18811 (release 7.8)	Family	Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four  serine residues on glycogen synthase (GS), in the sequence  SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the first  serine in the sequence motif SxxxS(P) (where S(p) represents a  phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of  beta-catenin by GSK-3 [1]. 	25.00	25.00	26.70	32.10	22.90	24.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.62	0.70	-4.89	4	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	38	10	34	79	0	160.30	40	81.67	CHANGED	MPCR+E.................SFLLLpQSVTlG.SsEVDpLVupIGEsLQLcsApcoPsSssts.G........hhAuhPss+uGs..................ssGuhRChhhcptpVR.GRuuPYsVs.sssGuSshs.p.h.................t.C+RGWhR..sssR+.........ts+stD-DDPHcLLQpLlLSGNLIKEAVRRLp.....huucsPsps.PGsh	...............................................MPst+c.............................salLLpQSVTls.StEVDtLVspIGEsLQLcssps.s.t.o.ss..G..............ush.sspst.............s..........tshtChhhcptthR.sRuuPY......sGsos................................+sW.R.......+c......................t.s+ss-.DDPH..cLLQpLlLSGNLIKEAVRRLp.t.................h.............................................	0	5	6	12
+5178	PF05351	GMP_PDE_delta		GMP-PDE, delta subunit	Finn RD	anon	Pfam-B_13828 (release 7.8)	Family	GMP-PDE delta subunit was originally identified as a fourth subunit of rod-specific cGMP phosphodiesterase (PDE)(EC:3.1.4.35).  The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues.  PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport [1].	25.00	25.00	30.20	30.10	18.20	18.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.85	0.71	-4.42	23	362	2009-09-11 15:38:04	2003-04-07 12:59:11	6	4	137	20	215	325	4	144.60	44	72.54	CHANGED	pspsNlasI-Fs+FpIRDhETGpVLFEls+ssss...........................................tt..p...ssuRhl+YpFsPpa.....................L+l+oV....GAs.lpFoV.G-cPlpsFRMIERHYF+spLLKoFDF-FGFCIPpScNThEpIYEhPslupphhppMlpsPaETpSDSFYFV-s+LlMHNKA-YuYs	....................spt.lhtlchspFplRDh-oGpVLFcls+s.ss........................................................................tsGRhlcYpFssth...........................L+h+sV....u..sp.lpFos.uscslpsFRhlERHYF+sp..lL+.....sa-F-FGFsIPs.SpNThEplYEhP.shSpth.tphlps..psps-ohaFs.-spLlh+s+sch.Y.......................................	0	80	100	155
+5179	PF05352	Phage_connector		Phage Connector (GP10)	Finn RD	anon	Pfam-B_13828 (release 7.8)	Family	The head-tail connector of bacteriophage 29 is composed of 12  36  kDa subunits with 12 fold symmetry. It is the central component  of a rotary motor that packages the genomic dsDNA into pre-formed  proheads. This motor consists of the head-tail connector, surrounded  by a 29-encoded, 174-base, RNA and a viral ATPase protein [1,2].	25.00	25.00	31.80	30.90	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.89	0.70	-5.19	4	23	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	22	39	0	24	2	271.50	30	88.42	CHANGED	SYKo....Is-IQRp+....tNR..WFhaYhpYLhSLAYQhFEWEsLPsolDP.FLEKplHQhGaVuFYKDshhGYIAspGsLSGplshYNQPshap...ASSssYQKpFcLY.....Yc...Dh+Ecs.G......lVIYNNshthPTlshLELFAtcLAELKEhItVNQNAQKTPVlItAsDNN.LShKplYNpYEGNtPVIFspcphD..........oDsIcVFKTDAPYVlDKLsspKpsVWNEhMTFLGIpNANh-KKERhVsSEVpSNs-QIpuSuslaLKuRpEACchINEhYGLNlpVKhRh-IV	....................................................h...............................p..lpshhhplFpaEshPsslssh.LEp.l+Q.G.hVshh+Dthhs.hlhh.tshssthshYsp..s..shFp......uss.sa.pph...clhp....ap...chp.ps.s..............VVhhN....Nsh.hs.ssh-llEaYspcLA-lcto.hplNhpsp+sPhhItus-sN...plSlppLhsclpsGsPhl..hspcshs..........sDs..I-lh....s.ssssshls.cLppphpsphsEhhTaLGIpNssh-KKERhlscEApSNsphlpususIYhKuRpcAlchlNctYGLsIKsp.................	0	0	0	0
+5180	PF05353	Atracotoxin		Delta Atracotoxin	Finn RD	anon	Pfam-B_30981 (release 7.8)	Family	Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing he inactivation of voltage-gated sodium channels [1].  The structure of atracotoxin comprises a core beta region containing a triple-stranded a thumb-like extension protruding from the beta region and a C-terminal helix.  The beta region contains a cystine knot motif, a feature seen in other neurotoxic polypeptides [1].	25.00	25.00	35.00	76.10	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.72	0.72	-4.12	5	7	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	3	0	8	0	42.10	65	76.62	CHANGED	CA+KRuWCuKTEDCCCPMKCIYAWYNQQSSCQsTISulFK.cC	CA+KRsWCuKsEDCCCPMKCIYAWYNpQuSCQsTIoulaK.cC	0	0	0	0
+5181	PF05354	Phage_attach		Phage Head-Tail Attachment	Finn RD	anon	Pfam-B_59968 (release 7.8)	Domain	The phage head-tail attachment protein is required for the joining of phage heads and tails at the last step of morphogenesis [1].	20.80	20.80	20.90	22.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.38	0.71	-4.53	6	548	2012-10-01 22:58:23	2003-04-07 12:59:11	6	2	289	2	4	217	26	112.70	74	98.42	CHANGED	MuDFDNLFDsAlutADcsIlcsMGhsAslTSGpLpGuplsGVFDDPEsISaAuuGlRlEsSsPoLFVKTuslspL+RsDTLTIss-sFWVDRIoPDDGGSCaIhLsR.GpPPsssRRR	..............................MtDFpNhFDAAlAtsDcTIhthMGhS..AphT..SGtQsGu.lpGVFDDP.EsluaAGpGVRlEGSSPSLFVRTDsVRtlRRGDTLTIstE......sFWV.....DR.lSP.DD.GGSC.....aLWLs..R..G.PPAVNRRR.....................	0	0	0	1
+5182	PF05355	Apo-CII		Apolipoprotein C-II	Finn RD	anon	Pfam-B_6456 (release 7.8)	Family	Apolipoprotein C-II (ApoC-II) is the major activator of lipoprotein lipase, a key enzyme in the regulation of triglyceride levels in human serum [1].	22.10	22.10	22.10	24.50	18.80	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.69	0.72	-4.11	6	40	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	29	4	19	42	0	73.00	46	75.96	CHANGED	AphsQQDEssSPALLsphQESL.SYW-SAKAAAQcLYpKTYLPAVDEKIRDlYSKSTAAlSTYAGIFTDQlLShL+G-	............p.sQpDE.sSsuLLopVQESLhSYW-oAKssApsLYcKTYlsslDEKlRDhYSKoosAhoTYsGIhTDQlhplLtGc....................	1	1	2	6
+5183	PF05356	Phage_Coat_B		Phage Coat protein B 	Finn RD	anon	Pfam-B_51500 (release 7.8)	Family	The major coat protein in the capsid of filamentous bacteriophage forms a helical assembly of about 7000 identical protomers, with each protomer comprised of 46 amino acid, after the cleavage of the signal peptide.  Each protomer forms a slightly curved helix that combine to form a tubular structure that encapsulates the viral DNA [1].	25.00	25.00	28.90	28.70	23.60	22.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.82	0.72	-4.29	2	14	2012-10-01 20:22:05	2003-04-07 12:59:11	6	1	13	15	2	14	0	80.70	65	99.56	CHANGED	MKuMKppIAKFsPVtSFRNLCIAGoVTAAoShPsa.AuVIDTSuVEpAITDGpuDMpsIGGYIVGALVILAVAGLIYSMLRKA	..............MKQpIAKFsPVsSFRN..LCIAGoVT.AAoShPAF..A.....GVIDTSAVEuAIT-GQuDMcuIGGYIVGALVILAVAGLIYSMLRKA....	0	1	1	2
+5184	PF05357	Phage_Coat_A		Phage Coat Protein A	Finn RF	anon	Pfam-B_7225 (release 7.8)	Domain	Infection of Escherichia coli by filamentous bacteriophages is mediated  by the minor phage coat protein A and involves two distinct cellular receptors, the F' pilus and the periplasmic protein TolA.  These two receptors are contacted in a sequential manner, such that  binding of TolA by the extreme N-terminal domain is conditional on a  primary interaction of the second coat protein A domain with the F'  pilus [1].	20.80	20.80	22.80	23.00	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.11	0.72	-4.39	3	41	2009-01-15 18:05:59	2003-04-07 12:59:11	8	3	15	21	0	89	0	63.30	45	24.64	CHANGED	MKKllhAlshslPFYTH.........sATTsssCLuKPuhEsSho.NVWK-sco..RYANaEGCLashTGlVlss	....hpK...hhshslPhYoa............susspcsC.uK..............P....shEsShs.Nsap.sps..RYtNapGCLasATGVVVss....	1	0	0	0
+5185	PF05358	DicB		DicB protein	Bateman A	anon	Bateman A	Family	DicB is part of the dic operon, which resides on cryptic prophage Kim. Under normal conditions, expression of dicB is actively repressed. When expression is induced, however, cell division rapidly ceases, and this division block is dependent on MinC with which it interacts [2].	25.00	25.00	25.30	37.10	20.80	19.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.78	0.72	-4.49	3	416	2009-09-11 11:17:21	2003-04-07 12:59:11	6	1	215	0	1	106	0	61.40	74	95.88	CHANGED	METLLPNVNTSEGCFEIGVllSNKsFTEDAINpRKhEp-LLN-lCIlSMLARL+Lh.KGp+Q	METLLPNVNTSEGCFEIGVplSN.sFTEDAINpRKaEp-LLNclCIlSMLARL+Lh.KGptQ...	0	1	1	1
+5186	PF05359	DUF748		Domain of Unknown Function (DUF748)	Yeats C	anon	Yeats C	Family	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.73	0.71	-4.21	168	1412	2012-10-03 05:41:17	2003-04-07 12:59:11	6	20	431	0	618	1573	145	150.40	17	38.87	CHANGED	htlplsplplp.s.upl..pasD.....pphs..shp..hplpsLshpl.sslu.ot.s.sp......sslp..l....puplspt...uslphpGpls..shs.hpsp..lplshc...slsLsshpPY.hsph.hshplppGpLsh....cLphp....hp.ps.pl.pspsplt..lc....pLp..ls-.....ps.ss.....pshh...sLs....l	.........................................................................................lplsplplp.s..Gpl....papD...............tthp...shp......hplsslsh....sl...ssl..s..sh....s...sps.....................sslp....l...................pup.lsst...................uslshpGpls.........shs....php.........hplphp..slsLs.s....hp.sY....hsp.......h.....h.......sh....pl..p....p..GpLsh.......clphp........................hp.ps..pl..p.s...p...s...p.lt..ls....plp..ltp.....t..ps...................hh..........................................................	1	137	349	518
+5187	PF05360	YiaAB		yiaA/B two helix domain	Yeats C	anon	Yeats C	Domain	This domain consists of two transmembrane helices and a conserved linking section.	20.40	20.40	20.40	20.50	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.30	0.72	-4.42	19	1736	2009-01-15 18:05:59	2003-04-07 12:59:11	9	3	843	0	190	635	32	52.40	37	64.76	CHANGED	ahshsasuhlluhshhhlGlasus.hpLstKGaahhshhhslhuslslpKssRD	..........ahhhuhhshllulshhllGLW.sus...h...hLuEKGYahsslhhulFushuhQKshRD......	2	43	112	151
+5188	PF05361	PP1_inhibitor		PKC-activated protein phosphatase-1 inhibitor	Finn RD	anon	Pfam-B_69711 (release 7.8)	Family	Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction [1].	20.70	20.70	21.10	22.10	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.88	0.71	-4.51	8	231	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	78	4	125	200	0	108.80	38	79.73	CHANGED	MAup+lG+Rhppp.pSss+upu..pustslQ+RpARVTVKYNRKELQRRLDVEKWIDspL-ELYpG+E--MPE.EVNID-LLDLpoDE-Ro++LpslLpuCsssTEsFIsELLt+L+GL+KQptLpppGlchPp.ph.sph............cs	............................t.........................................t......+.+..pu+lTVKYsR+cL...p+...RLslEcWI.ppLpcLYp.....s..pE.-.-.......hP-...E.....IDlD-LLDhpo--pRsp....+l.p.clL...hs....Ch...+P...T....E...s...FIp-LLs+l+Ghp+.s.......................tp................	2	18	29	61
+5189	PF05362	Lon_C		Lon protease (S16) C-terminal proteolytic domain	Studholme DJ	anon	Merops	Domain	The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activity resides in a C-terminal domain. The Lon proteases are classified as family S16 in Merops.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.21	0.71	-5.02	25	7706	2012-10-03 01:04:38	2003-04-07 12:59:11	8	39	4472	58	2231	8849	3459	174.80	32	25.91	CHANGED	slsscsLccaLGh.+F+hspA-ccDpVGlVTGLAWTpVGG-lLsIEushhP..GKG.+LplTGpLGDVMKESApAAhSYlRS+ApchGIcscha-cpDIHlHVPEGAsPKDGPSAGlsMsTALVSsLTGhsV++DVAMTGEITLRGRVLPIGGLKEKlLAA+RuGIKpVIlPc-Nc+DL.c-lPcsl+csLclhsVcplD-VL+hALst	.....................................................................................................................h........................................................................................G...hh.s..........................................G.....h....h.........lE.....s...........................................................t.........p...............s.........t..............h..............h...o...G..........h........t.............p.......................h.......p....c.....u........h..................s...........t.....h....hp....................t.......................................................................................................................................................................................h...........t................t.....................p...h....H.lp...h...s.t...u.uh....s..h..D...G......PS..A.G..lsh..s..s..A.l...l.............S...s...L.....o...........s.......t.............s...l......c....p....s......l....A.......h...T...G-Iol...pG.c.VhPI..G.G.lcEKl........l....A........A..p.......R.......u.......G.h.......c...t...l.....l.....l......P...............p....p...............N........t.+......-......l......p..............-..............l.........s....p......t.....l..........p....p....t.h.....p.....lh.s.V.p.p.lc-slphh..t.....................................................	0	804	1468	1899
+5190	PF05363	Herpes_US12		Herpesvirus US12 family	Finn RD	anon	Pfam-B_62991 (release 7.8)	Family	US12 a key factor in the evasion of cellular immune response against HSV-infected cells. Specific inhibition of the transporter associated with antigen processing (TAP) by US12 prevents peptide transport into the endoplasmic reticulum and subsequent loading of major histocompatibility complex (MHC) class I molecules [1]. US12 is comprised of three helices and is associated with cellular membranes [1].	21.00	21.00	23.70	23.50	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-9.79	0.72	-3.47	2	19	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	1	0	19	0	80.40	53	95.56	CHANGED	MSWALchsDhFLDs.Rss.RTYuDVpsEIpKRtREDREAARTAVpDPEhPLLpsPslhs-.As....ptohGsA+pppttsts.uP	......MuWALchsDsFLDs.Rss.RTYADVRcEIsKpuRED.REAARTAVtDPERPLLpsPulhP-hAs....sAohGsA+pppttshh.uP............	0	0	0	0
+5191	PF05364	SecIII_SopE_N	SecIII_SopE; 	Salmonella type III secretion SopE effector N-terminus	Finn RD, Moxon SJ	anon	Pfam-B_18665 (release 7.8)	Domain	Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, one of these toxins, can activate Cdc42 in a Dbl-like fashion via its C-terminal GEP domain Pfam:PF07487 [1]. This family represents the N-terminal region of SopE. The function of this domain is unknown.	19.10	19.10	21.80	45.70	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.40	0.72	-4.15	2	141	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	106	0	2	45	0	70.20	79	31.04	CHANGED	TpITLSsQpaRIp+p-sp.lKEKoTEKs.hAKSIhAV+NpFIpLpopLS-RF..HppT-.ssTHFHRGsASEGR	.TNITLSTQHYRIHRSDVEPVKEKTTEKDIFAKSITAVRNSFISLSTSLSDRFSLHhQTDIPTTHFHRGSASEGR...........	0	0	0	1
+5192	PF05365	UCR_UQCRX_QCR9		Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	Finn RD	anon	Pfam-B_18986 (release 7.8)	Family	The UQCRX/QCR9 protein is the 9/10 subunit of complex III, encoding a protein of about 7-kDa. Deletion of QCR9 results in the inability of cells  to grow on grow on-fermentable carbon source n yeast [1].	20.40	20.40	20.40	20.70	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.59	0.72	-4.33	33	239	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	211	52	166	258	1	53.30	36	49.35	CHANGED	hsslYpslFRRNSsalssIhsGAFsFEh.AFDsusspla-shN+GKhWKDI+tcY.	......h.ptlYphlh+RsSsassslhsGAFhFEt.uaDtusspla-phN+GKhWKDI+tph......	0	51	86	138
+5193	PF05366	Sarcolipin		Sarcolipin	Finn RD	anon	Pfam-B_33603 (release 7.8)	Family	Sarcolipin is a 31 amino acid integral membrane  protein that regulates Ca-ATPase activity in skeletal  muscle [1].	26.40	26.40	26.80	65.70	20.60	26.30	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.43	0.72	-4.54	2	17	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	17	1	9	12	0	30.60	87	100.00	CHANGED	MthsTpELFlNFTlVLITVlLMWLLVRSYQY	MthsTRELFLNFTlVLITVILMWLLVRSYQY	0	1	1	1
+5194	PF05367	Phage_endo_I		Phage endonuclease I	Finn RD	anon	Pfam-B_22152 (release 7.8)	Domain	The bacteriophage endonuclease I is a nuclease that is selective  for the structure of the four-way Holliday DNA  junction [1].	25.00	25.00	25.60	25.40	22.60	21.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.73	0.71	-4.81	6	64	2012-10-11 20:44:44	2003-04-07 12:59:11	6	1	59	24	2	65	330	136.50	49	98.32	CHANGED	MA..uahAKthppVtAaRSGLE-KsuKQLEuKGlKh-YEpahlPYVlPASsH+YTPDFlLPNGIhVETKGLa-o-DRKKHLLIREQHPELDIRhVFSSSRTKLYKGSPToYu-WCEKaGhpFADKLIPVtWL+EsspclPhshLKsKKGcK	.........................................thtts.uaRSGLE-+lucpL-spGlpa-YEphclsYllPtp.sHpYTPDFlL.P.N..G..IhlEoKGha........-s-DR+KHLLI+EQaP-.L.DIRhVFSsSpo......KlYKGS.ToYu-WC-KaGhha.A.D.K....h.IPs-WL+E.ph.hs.shhh.ht........................	0	0	0	1
+5195	PF05368	NmrA		NmrA-like family	Finn RD	anon	Pfam-B_25329 (release 7.8)	Family	NmrA is a negative transcriptional regulator involved in the post-translational modification of the transcription factor AreA. NmrA is part of a system controlling nitrogen metabolite repression in fungi [1].  This family only contains a few sequences as iteration results in significant matches to other Rossmann fold families.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.33	0.70	-5.11	25	4570	2012-10-10 17:06:42	2003-04-07 12:59:11	8	40	1637	75	2377	19410	5486	230.00	20	76.81	CHANGED	ILVlGuTGh.GptlVcAulc.....sGapshALsRcs.................cschhpshpstGspll.pGD.ls...........................-+pSLscAlKtVDlVhssss........stpltpthpllcAhKcAG.VK+Fl.Sphuscsc..tspuh.PuhstF-pKtplc+hlcut......GIPaTaVhsshFss.Flsshst...ttsssspsphslhususscslhh...sEcDlGsaslpslcD.Pcph.pshhlphssshLohsElsslapKt...lGKs.........................................................V+Ysp	...................................................................................................lhlhG.A.T...G.p...h...G...t......t...l....l.c.......s.L.lp....................ss...h......p.....l...h.......s.....l.......s...R..ss............................................................p.p..........h...p.....t.....l.......t........t......t.......G.......s..........p........l.......h......p......u..D...h...s................................................................................s........s...u....L........t...p.....A.....h........p............G.......s.......-.......s......l........h...h..h...s..s...................................stch.....t.......p.....t......t.........s......l....l.......c.........A...........A....p........p...........A.......G.....V.....c.........+........h..........l..............h..............o..........s.........h.........s........t.........s........s.........t..............s...........................................................................h........s...........h........h.....s............t.........+......h....p.......h....c....c....h...l.....p.pp........................s.l...s...a....T...h..l......p........s.....u.......h.......a...h.............c................h.......h...s.....hh........................h.t....t............................h.......h.....h.h......s......s...s..s....t..hshh.....................sttD.h...u....t....h....s....s.t........l....l....p.............p.....s.....t....p.......h....................s.....p....h...h.........h.....s...s..........p........t........h........o......h.p......c.l.sthhpch....h..G..pp......................................................................................................................................................................................................................................................................................................	0	562	1309	1950
+5196	PF05369	MtmB		Monomethylamine methyltransferase MtmB	Finn RD	anon	Pfam-B_58618 (release 7.8)	Family	Monomethylamine methyltransferase of the archaebacterium Methanosarcina barkeri contains a novel amino acid, pyrrolysine, encoded by the termination codon UAG [1,2]. The structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold [2].	25.00	25.00	148.90	148.60	16.50	16.50	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.52	0.70	-6.32	3	22	2009-09-11 12:54:46	2003-04-07 12:59:11	7	1	14	0	15	29	4	418.70	52	99.42	CHANGED	TFRKSFDCYDFYDRAKVGEKCTQDDWDLMKIPMKAMELKQKYGLDFKGEFVPTDKDMMEKLFQAGFEMLLECGIYCTDTHRIVKYTEDEIWDAINNVQKEFTLGTGRDAVNVRKRSVGDKRKPIVQGGPTGSPISEDVFMPVHMSYALEKEVDTIVNGVMTSVRGKuPIPKSPYEVLAAKTETRLIKQACAMAGRPGMGVXGPETSLSAQGNISADCsGGMpSTDSHEVSQLNELKIDLDAIAVIAHYKGNSDIIMDEQMPIFGGYAGGIEETTIVDVATHINAFVMSSASWHLDGPVHIRWGSTNTRETLTIAGWACATISEFTDMLSGNQYYPCAGPCTEMCLLEASAQSITDTASGREILSGVASAKGVVTDKTTGMEARMMGEVARATAGsEISEVNKILDKLVuLYEKNYASAPAGKTFQECYDVKTVTPTEEYMQVYDGARKKLEDLGLVF	...................tKphssYDaaDRA+sGEKsopDDW..DlMpIPhKuhELKpKYsl-F.c.s.E.FlPTDcDMh-+LFpAGhEMLlECGIYCTDTcRllKYTEDEIh-AIsNs.KEasLGpG+DulsVhcRuhsDp...p...tPllQGGPTGuPlSEDlFhslHhSYAhE..VD.sI.VsGVhpolpG+sshPtSPaElhAu+oEsRLlKpAsthAGRPGMultGPETuloupGsl.uuDssGGhspsDSHEVSQLsELKIDl-AlshhAHYpssuslIMsEQMPIFGGYA.GGl.EETsIVDVATpINuhlMosAoaHLDGPVHlRWGSTsTREsLhlAGassusloc...Tch..lsGNQYYssAGPCTEMCLLEsuAQuITDTASGRElLSGVAuAKGVssD+oTGhEARhMGElARAsAGh-lo..ElNtIL-+LVuhYE...c...sassAPt...GKsFpECYDVpT...lsPT-EYhplYDtAtKcLc-lGL..............	0	5	10	11
+5197	PF05370	DUF749		Domain of unknown function (DUF749)	Finn RD	anon	Pfam-B_54547 (release 7.8)	Family	Archaeal domain of unknown function.  This domain has been solved as part of a structural genomics project and comprises of segregated  helical and anti-parallel beta sheet regions.	25.00	25.00	74.80	74.60	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.58	0.72	-4.04	5	27	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	27	2	19	26	2	87.80	44	89.91	CHANGED	FlAsLlGIhTlKE.LsEEhcsFV+lKAulDK+ELcDDsclAIlNIcGTTSYaVlFLDsssSlEEI++ELEEs..GAclN+sScpIL++aL	FlAsLluIhslcE.Lss.EhpsaVcl+Aul-cR.EL.ccsDplAILNIpGTsSYpVhFlDp.ssI-cIKc-Lcch..sAclNasSccIl+pal	0	4	9	15
+5198	PF05371	Phage_Coat_Gp8		Phage major coat protein, Gp8	Finn RD	anon	Pfam-B_31655 (release 7.8)	Family	Class I phage major coat protein Gp8 or B.  The coat protein  is largely alpha-helix with a slight curve [1].   	19.80	19.80	19.80	21.50	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.63	0.72	-4.41	7	29	2012-10-01 20:22:05	2003-04-07 12:59:11	7	1	21	13	4	45	1	51.20	51	69.77	CHANGED	AEssss...AptAhDSLpspAT-hIu.sWshVsslVsAsluIKLFKKFsSKA	......................ss.....AtsAhDuLtspAs-hIGhsWslVVslVGAsluI+LFKKFoSKA	0	0	3	3
+5199	PF05372	Delta_lysin		Delta lysin family	Finn RD	anon	Pfam-B_45919 (release 7.8)	Family	Delta-lysin is a 26 amino acid, hemolytic peptide toxin secreted  by Staphylococcus aureus. It is thought that delta-toxin  forms an amphipathic helix upon binding to lipid bilayers [1]. The precise mode of action of delta-lysis is unclear.	25.00	25.00	62.60	62.50	17.80	16.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.34	0.72	-6.77	0.72	-4.58	6	86	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	79	3	2	18	0	25.00	94	64.33	CHANGED	MAuDIISTIuDFVKLIl-TVpKFTK	MAQDIISTIGDLVKWIIDTVNKFTK	0	1	1	2
+5200	PF05373	Pro_3_hydrox_C		L-proline 3-hydroxylase, C-terminal	Finn RD	anon	Pfam-B_32425 (release 7.8)	Domain	Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse oxidative reactions in a range of metabolic processes.  Proline 3-hydroxylase  hydroxylates proline at position 3, the first of a 2-OG oxygenase catalysing oxidation of a free alpha-amino acid. The structure contains conserved motifs present in other 2-OG oxygenases including a  jelly roll strand core and residues binding iron and 2-oxoglutarate,  consistent with divergent evolution within the extended family.  The structure differs significantly from many other 2-OG oxygenases in possessing a discrete C-terminal helical domain.	25.00	25.00	26.90	26.30	20.50	18.40	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.21	0.72	-3.98	5	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	4	5	15	0	100.30	26	34.00	CHANGED	spcEshtDsE..sssssPsVcsRKPaT-EscEuILu.lStlIu+tNFRDIVFlLSKlHFpYKVHssEsYDWLlEIuKRsGD-cLVEKAppl+RFhltcRAlGE	...................hshp..ssthpstlssRsths-pphEpLlu.lSplloctNaR-llhhLuKlHFp+-sssspsaDWLp-lA+RoGDsAllpKAcplRcahlpcRshsE.........	0	2	4	5
+5201	PF05374	Mu-conotoxin		Mu-Conotoxin	Finn RD	anon	Pfam-B_34209 (release 7.8)	Family	Mu-conotoxins are peptide inhibitors of voltage-sensitive sodium channels [1].	19.30	19.30	20.50	20.40	18.20	14.80	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.30	0.72	-4.14	4	7	2012-10-01 22:06:18	2003-04-07 12:59:11	7	1	5	6	0	12	0	21.60	60	58.75	CHANGED	RDCCTPPKKCKDRpCKPh+CCA	..R.CCssPKpC+sRpCKPp+CC.	0	0	0	0
+5202	PF05375	Pacifastin_I		Pacifastin inhibitor (LCMII)	Finn RD	anon	Pfam-B_35181 (release 7.8)	Family	Structures of members of this family show that they are comprised of a triple-stranded antiparallel beta-sheet connected by three disulfide bridges, which defines this as a novel family of serine protease inhibitors [1,2]. 	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-8.66	0.72	-4.44	36	190	2009-01-15 18:05:59	2003-04-07 12:59:11	8	32	46	12	121	244	4	37.20	36	11.86	CHANGED	pC..sPGpsaK.p-..CNsCpCstsGh...ssCTh+uC.st.httsss	.............sGpsa+..pD..CNsCpCs.sGp...hsCTpphCsst......s.......	0	66	91	112
+5204	PF05377	FlaC_arch		Flagella accessory protein C (FlaC)	Studholme DJ	anon	Manual	Family	Although archaeal flagella appear superficially similar to those of bacteria, they are quite distinct[1]. In several archaea, the flagellin genes are followed immediately by the flagellar accessory genes flaCDEFGHIJ.  The gene products may have a role in translocation, secretion, or assembly of the flagellum. FlaC is a protein whose exact role is unknown but it has been shown to be membrane-associated (by immuno-blotting fractionated cells) [2].	27.00	27.00	27.00	33.50	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.53	0.72	-4.07	10	60	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	54	0	41	64	2	55.90	39	17.60	CHANGED	RlsELENcls+lsss...lsol++ENp-l+sslEcl-EsV....+-llsLYElVSp...plNP.Fl	..............RlsElEscls+lcss...lssl+pENcpl+csl-cl--sl....+clhsLYElVSp...pINP.Fl..........	0	5	21	32
+5206	PF05378	Hydant_A_N		Hydantoinase/oxoprolinase N-terminal region	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of the Pfam:PF01968 family.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.01	0.71	-4.76	64	2308	2012-10-02 23:34:14	2003-04-07 12:59:11	8	31	1319	0	1145	2398	1126	178.40	28	21.44	CHANGED	plGIDhGGTaTDslhhctsp......................thltshKlhoo......csshpGlppulpphttp.........hsplshlhhuTTluTNAlLEpcG............spsuLlsstGapDhlphshttp.th................ps.h.hc.hltlstRhss.c............................Gp.lpsl.D.ptlcphlpplpsptlpulAVshhaShtNPpHEhpltcllcchs	..................................lulDhGGTFTDslh...hcss....................................................stltshKl.os.........................cs...sspGlhpslpphh.tp..h.t..................hspls.......t..lthGT...........T...luTNAllER+G............s+s.u.Ll..s.o..p..G.a.c.D.h.lt.l.s..p......p..t...p..s..ph......as.....h...............................s...h.hhp..p.......hh..t.l.spRlsh.c.................................................................G.pll.p.sl...-.t.p.p.lcpt.l.p....p.l....t....s.........p..G..lc..ulAlshhaSa..t............p...s..p..H..Etpltclhpc..h.........................................................................................................	0	363	745	976
+5207	PF05379	Peptidase_C23		Carlavirus endopeptidase 	Studholme DJ	anon	Manual	Domain	A peptidase involved in auto-proteolysis of a polyprotein from the plant pathogen blueberry scorch carlavirus (BBScV)[1]. Corresponds to Merops family C23. 	25.00	25.00	33.70	43.10	24.50	22.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.85	0.72	-4.01	12	125	2012-10-10 12:56:15	2003-04-07 12:59:11	6	8	50	0	0	124	0	87.30	35	5.41	CHANGED	.KNsCVIcAlupslpRpsscllpVLpcpsscclhc-ltpGtGlphhpLp.lFpsFDIsApVs.suchhhlNspGphptpFtlps-HhSa	....hNsCslpAlAsALsR+ps-VLslLscsss.sclh-pLtpGtGlshhhLtphFchFsIsAplshsGchhllNspG+lpuhFclps-Hlpa..	0	0	0	0
+5208	PF05380	Peptidase_A17		Pao retrotransposon peptidase 	Studholme DJ	anon	Manual	Family	Corresponds to Merops family A17. These proteins are homologous to aspartic proteinases encoded by retroposons and retroviruses.	20.60	20.60	20.60	20.60	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.17	0.71	-4.38	8	650	2009-01-15 18:05:59	2003-04-07 12:59:11	8	62	40	0	609	764	6	127.10	25	12.22	CHANGED	PTKRElLSplu+lFDPLGhluPlhl+uKlhhQElWpps......luWD-plPp-lppcWtsalcpLssLpQlRlPR.alshssspslpLHuFsDASpcAYuAAlYhRs.p.sssIpVsLlsAKTRVAPlKss.SIPRLELsAAlLLoRLssslpsphshtsschhsWT	.................................................................o+Rtlhs.huphaD.PhGhhss..........hhl.hKhhhp.plhpt.t..........hsWc..p...ls..t..ph.......ppW.thhp..ph.......t.......p.t.h..p.hs...R...h..h.................t........t......p......h...p...lh...hFsDAS.p..tuausss....Ylhh..........t.t..t......s.p.h.lh..uKs+l.tP..h..c...t........ol..P.....+hEL.uh.hssph.....l.pth..t........................................................................	0	393	436	605
+5209	PF05381	Peptidase_C21		Tymovirus endopeptidase	Studholme DJ	anon	Merops A17	Family	Corresponds to Merops family C21. The best-studied plant alpha-like virus proteolytic enzyme is the proteinase of turnip yellow mosaic virus (TYMV). The TYMV replicase protein undergoes auto-cleavage to yield two products.  The auto-peptidase activity has been mapped to the central part of this polyprotein.	25.00	25.00	34.00	50.10	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.22	0.72	-3.93	13	44	2012-10-10 12:56:15	2003-04-07 12:59:11	7	4	32	0	0	51	0	105.50	35	5.58	CHANGED	Ps.hsCLLoAlSspT+lSc-cLWcoLpslLPDS.LsNpElsoLGLSTDHLTALAahYshpsslaSscGslhaGlpsupppIsIoHTsGPP....uHFSs...hh.tssshsG	.....PthsCLLsAlSstTslo.cpLWpsLsshLPDSLL.ssp-lsshGLSTDHhssLAahaphpsphhospt.lphGlpsAopphpIpHTsGss.......sHFsh...h........sss.........	0	0	0	0
+5210	PF05382	Amidase_5		Bacteriophage peptidoglycan hydrolase 	Studholme DJ, Garcia E	anon	Pfam-B_6845 (Pfam7.8)	Family	At least one of the members of this family, the Pal protein from the pneumococcal bacteriophage Dp-1 Swiss:O03979 has been shown to be a N-acetylmuramoyl-L-alanine amidase [1]. According to the known modular structure of this and other peptidoglycan hydrolases from the pneumococcal system, the active site should reside at the N-terminal domain whereas the C-terminal domain binds to the choline residues of the cell wall teichoic acids [2,3].  This family appears to be related to Pfam:PF00877.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.81	0.71	-4.58	8	235	2012-10-10 12:56:15	2003-04-07 12:59:11	8	30	204	0	32	361	31	134.80	28	32.91	CHANGED	shEpuIAWMtARKG+.VoYSMs.hRsGPsSY.DCSSSVYhAL+uAGASsuGWhlNTEhhHsWLhcNGacLIucNtsWsApRGDIhI..WGt+.GuSuGAGGHsGMFIDusNIIHCNY...usNGIoVsNasppshhuGthhsYlY..Rhssuuoss	.................................p..p.hltah.....t.p..c.sp..l.s..YS..M....R.G.....ss...u.......h....DCSuu..lhh.A..Lp.t.u.Gh......s..s.......u.h..h.s......s..Tpshhs.L..p.p..sG..a.ppl.s.....p...s...............h.......s....s....pcGDIhI..hGtp...GtSuG.s.sGHsslh...h....s..t....s..p...hIps...s..h..........s.s.s.............................................s..........................................................................	1	13	19	26
+5211	PF05383	La		La domain	Bateman A	anon	Bateman A	Domain	This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins [1]. The function of this region is uncertain.	21.30	21.30	23.30	21.90	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.81	0.72	-4.17	33	1403	2009-01-15 18:05:59	2003-04-07 12:59:11	12	36	318	14	875	1319	11	58.80	37	10.47	CHANGED	lh+QlEYYFSDpNLspDpFL+pphsc..-GaVPlpllusFp+l+pLo..............hphIlpAL+pS	.........lt+QlEaYFS......cpNLs+.DtFL....hpph....c....p..........-......G....a.....VPlpllss.Fp+l+pLo...............sDhphlhcAL+pS...............................	0	260	430	669
+5212	PF05384	DegS		Sensor protein DegS	Moxon SJ	anon	DOMO:DM08518;	Family	This is small family of Bacillus DegS proteins.  The DegS-DegU two-component regulatory system of Bacillus subtilis controls various processes that characterise the transition from the exponential to the stationary growth phase, including the induction of extracellular degradative enzymes, expression of late competence genes and down-regulation of the sigma D regulon [1]. The family also contains one sequence Swiss:Q8R9D3 from Thermoanaerobacter tengcongensis which are described as sensory transduction histidine kinases.	24.20	24.20	24.60	26.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.73	0.71	-5.02	21	178	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	173	0	64	164	0	156.90	37	40.64	CHANGED	DcIlpchlcslpcSKc-IFcIuEpuRpEapcLppELcplKpclsclIpcsDcLEhppRhARpRLsEVS+pFppYSEp-I+cAYEpAcplQlcLslhRpcEppLRcRRD-LEpRLhslpcTI-RAEpLluQluVsLsaLsuDLcpluctlE-hpp+QphG	..........DpIlpchlcsl-sSKppIFpIuEpuRpEhcpLpcELcplKppltclIcplDpLEhpp+puRpRLsEVS+sFpcaSEc-I+pAYEcAcclQlcLshh+p+EppLRpRRD-LERRLtslpchlERAEpLluQlsVlLsYLssDLppls.hl-shpp+Q.hG.................	0	32	53	57
+5213	PF05385	Adeno_E4	M_adenovirusE4; 	Mastadenovirus early E4 13 kDa protein	Moxon SJ	anon	DOMO:DM07617;	Family	This family consists of human and simian mastadenovirus early E4 13 kDa proteins. Human adenovirus type 9 (Ad9) is unique in eliciting exclusively estrogen-dependent mammary tumours in rats and in not requiring viral E1 region transforming genes for tumorigenicity. E4 codes for an oncoprotein essential for tumourigenesis by Ad9 [1].	25.00	25.00	31.00	31.00	23.30	19.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.51	0.72	-4.10	8	88	2009-09-11 08:31:06	2003-04-07 12:59:11	6	1	68	0	0	64	1	107.20	50	90.15	CHANGED	MsLPsLPsPPVscDpuuCIuWLGLAauollDllRsI++cGlhIoPEAEplLsuLREWLaauapTERp+R+DRRRRslCpuRTaFCapKYEpVR+pLh.YDssppTlSl..ts	....MlLPsLPsPPl.c-ppuCIsWLGhAYsslsDVlRsIRh-Glhlos-ApcLLpsLREWLYauahTERp+R+..D.RRRRtlCsuRstFCapKY-pVRKplH.YsssppTlslt.s......	0	0	0	0
+5214	PF05386	TEP1_N		TEP1 N-terminal domain	Bateman A	anon	Bateman A	Domain	This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain.  However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.	25.00	25.00	25.60	25.00	24.30	16.80	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.37	0.72	-4.49	8	102	2009-01-15 18:05:59	2003-04-07 12:59:11	6	16	20	0	38	89	0	29.80	72	4.25	CHANGED	hEKlHGHlSsHPDILSLENRCLshLPDLQP	..MEK.HGHVSAHPDILSLENRCLATLPDLKs......	0	4	4	4
+5215	PF05387	Chorion_3		Chorion family 3	Moxon SJ	anon	DOMO:DM07741;	Family	This family consists of several Drosophila chorion proteins S36 and S38. The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary [1].	21.20	21.20	21.20	21.50	21.10	20.70	hmmbuild  --amino -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.97	0.70	-4.96	4	75	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	25	0	19	73	0	201.60	45	88.03	CHANGED	Mspa.alLhlsAssL..........ApAuYGusGuuG.GhGuuthuAuuuA......tsusGGst.SG..........GshpuusApl.spPspsu+lspsQuphtu.p.s.sYp.hhppusslupSls.sp................................NptpllhppP.sPIIV+pP..PsphlsstPPhVVKsAPVlh+h.PuVlhpp.hlp+hPpPlplpPVYVpVhKPst..Et.hVstspQsYtpsuaGsSphSt............GYGuusutuusAuuAuStusupA	...hsh..hlhAlAA.s.l.........sSANYGsstu.....tu...Gptht.h..ussss...tthsssAsGGstsuu...........p.hsupAth...ps.s.s-tAthhttsQuphtu.p.s.sYp.h.ppupslspSls.sp...............................pNptpllhppP.sPIIV+pP..PsthlsstPPhVV+ssPVlh+h.Pullhpp.hlp+hPp.lplpPVaVpVhKPst..Et.hss.st.sYsQ.s.......p.htt..................uautu.stu.tstsssst.....s...............................................	0	2	2	11
+5216	PF05388	Carbpep_Y_N		Carboxypeptidase Y pro-peptide	Moxon SJ	anon	DOMO:DM08350;	Family	This family is found at the N terminus of several carboxypeptidase Y proteins and contains a signal peptide and pro-peptide regions [1,2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.68	0.71	-3.91	6	94	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	88	0	65	87	0	107.80	26	20.30	CHANGED	M+LosSlL..suLAhshssApALul......QpPlu.......................h..ttpsll-psucslu......-sLcslsspl+shWsEMthpFPsplspLpapopPKhtlstKsss..WDF...........pVpssplsNY+L	............................................................................h....hs.st.Ahsh............Qp.ht.................................htpsh..hppht...ctht...........-.lc.sLos-s+slWsElthhaPcs....h.pphp...h...h...o...tPK..ts++scsc.WDa...........lV+su...cl...............................	0	13	34	58
+5217	PF05389	MecA		Negative regulator of genetic competence (MecA)	Moxon SJ	anon	DOMO:DM05333;	Family	This family contains several bacterial MecA proteins. The development of competence in Bacillus subtilis is regulated by growth conditions and several regulatory genes. In complex media competence development is poor, and there is little or no expression of late competence genes. Mec  mutations permit competence development and late competence gene expression in complex media, bypassing the requirements for many of the competence regulatory genes. The mecA gene product acts negatively in the development of competence. Null mutations in mecA allow expression of a late competence gene comG, under conditions where it is not normally expressed, including in complex media and in cells mutant for several competence regulatory genes. Overexpression of MecA inhibits comG transcription [1,2,3].	21.10	21.10	22.10	21.50	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.32	0.70	-4.80	42	1309	2009-09-11 15:15:24	2003-04-07 12:59:11	7	2	1134	28	147	674	7	222.50	30	97.79	CHANGED	MclERIN-sTlKlhIoh-DLp-RGhshpDlhhspc+sEchFashh-Elcp-csFps.sGslshQVhshp.pGl-lhlTKsp.....pt..t....................ptss-plpchlcpph..............................t-hcspl-.............................hllpFsshEDlIsLucplp..tslts...pLYpacspYYLtlhh...pphsptphcshluhhhEauptoshot..h.hLpEYGchlhppsAlppl+p	.......................MchE+Is-sTlKlhlohpDLp-RGhshtDlh.h.s.pc+sE-FFashh-El.....c.--.s.Fhs..sG.sL.h...h..pVhshp.cGl-VhlTKuc............cp..php...s.................................sp.ts-phpchlcppl..............t..p.........................................................p..p.t.php............................................................................ttppsthp..hl..lpFscl-Dllshu..cplph...p...t...hps..pLYp...h..s..s...c..YYLslhh.............p..p..h.sp.hhsphhuhlhEa..u...p...s...os...h...Tp..........t...hL...pEYGchlhscsAlpplp..............................................................	0	45	89	117
+5218	PF05390	KRE9		Yeast cell wall synthesis protein KRE9/KNH1	Moxon SJ	anon	DOMO:DM07408;	Family	This family contains several KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, which are required for beta -1,6-glucan synthesis in yeast [1].	20.50	20.50	21.60	21.60	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.54	0.72	-3.70	5	120	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	87	0	79	106	0	98.00	42	36.75	CHANGED	IDSKSFTVPYTcQTGKoRaAPMQhQPGTKVTATTWSRKYATSAVTYYSThsuoP-QtTTlTPGWSYTISSuVNYATPAPMPSDNGGWYsPpKRlSLoTRKlNs..hR+l	..............tsaTVPYshQT.GhoRYAPMQhQP.sT+l.T..A.p.....Ta..ohp..asT.SuVohaoT.hhs..s.ss.tTTlTsuhoYolsSt.NhAoPAPhPs-...hY....h..................h..........................	1	11	35	63
+5219	PF05391	Lsm_interact		Lsm interaction motif	Bateman A	anon	[1]	Motif	This short motif is found at the C-terminus of Prp24 proteins and probably interacts with the Lsm proteins to promote U4/U6 formation [1].	21.40	21.40	21.40	22.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.69	0.73	-6.64	0.73	-4.30	9	94	2009-01-15 18:05:59	2003-04-07 12:59:11	6	14	80	0	54	86	0	20.50	47	2.66	CHANGED	sptsssst.hSNDDFRKhFL+	..........sscss.hSNsDF+KhFL+..	0	10	20	34
+5220	PF05392	COX7B		Cytochrome C oxidase chain VIIB	Moxon SJ	anon	DOMO:DM07697;	Family	\N	20.70	20.70	22.00	39.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.79	0.72	-4.40	8	75	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	43	51	35	92	0	75.90	63	98.05	CHANGED	MFPLAKsALupLplpSIQQssARQ.uHpK+oP.DFHDKYGNulLASGusFClAsWoYssTQlGIEWNLSPVGRVTPKEW+-Q	...................MFPlu+sALspL.plRSIQQshARQ.uHpK+oP.DFHDKYGNuVLAuGAsFClusWsYssTQlGIEWNLSPVGRVTPKEW+cp...	1	2	3	9
+5221	PF05393	Hum_adeno_E3A		Human adenovirus early E3A glycoprotein	Moxon SJ	anon	DOMO:DM07622;	Family	This family consists of several early glycoproteins from human adenoviruses.	21.40	21.40	21.40	22.50	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.48	0.72	-4.32	3	49	2009-09-11 15:19:00	2003-04-07 12:59:11	6	2	27	0	1	39	0	97.20	47	42.85	CHANGED	MTsTTNA.......sTATGLTSTpNhPQVSAFVNNWANLGMWWFSIALMFVCLIIMWLICCLKRKRARPPIY+PIIVLNPNNDGIHRLDGLKsCSFSLsV	.........................t.ptss.s..ssh...............s..hTSLA.TNETsVshMasQsau....GL..D..I..T..FLVVCGIFILlVLLYFVCCKARcKSRRPIYRPVIG.......................ps..................	0	0	0	1
+5222	PF05394	AvrB_AvrC	Pseu_avirulence;	Avirulence protein	Moxon SJ	anon	DOMO:DM07798;	Family	This family consists of several avirulence proteins from Pseudomonas syringae and Xanthomonas campestris.	20.00	20.00	21.80	21.50	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.07	0.70	-5.45	6	40	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	22	4	2	32	1	292.60	48	94.26	CHANGED	MGCloSKtssluSsshpsutosSs............pt+ushhs.LpGPsptScLpsapQuLVGsARWPDct......N+sssPcphcYscShYppSRthGuSlAsGcIsSFp-LWpcAp-WRhSRhsps-sl...FuosRsPNoc..FVTPLtcPYc.lh-RhsN+pDucschhpDphFhs.csKsaR.sGpIsGEsIPLTplosusDccA..-RhpchhpcLcspuhpDh...ucPNhIsHTsAEYlPpIhcHlEsLYppAlDsuLSppcALchlAclHWWsApAhPDcRGSAAKAEhssRSIApA+Gl-LPPhRpGIVPDlEAMhhuccpFVcsY.uhFEps	.....................................................................................................................................................................................................ssh....uS.sstsuuopSp............thpushhs.LpGPsphScLo.cpQSLVGsARWPDct......N+ssT.cphcYs+ShYpuSRhAGuuIASGpIsSFs-LWpcAppWRhSRhuus-so..sFAs.RhPNoc..FVTsLppPYc.ll-RhpN+sDuchchh-sphhttlcsKsaR.pGtIsGEsIPhTplssusDcsA..sRhcsh..pc.cppthpp.httucPshIsHTsAEYl.pIhcHlEsLYhpAlDsoLpc+cAhcllAclHWWsAsAsPDcRGSAAKAEhusRSIApA+Gl-.hPPhRpGIVPDlEAMhp.SccpFVtpYsshF-p.......	1	1	1	1
+5223	PF05395	DARPP-32		Protein phosphatase inhibitor 1/DARPP-32	Moxon SJ	anon	DOMO:DM07433;	Family	This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1 [1]. It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1 [2]. DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive [3]. A mutant form of DARPP-32 has been linked with gastric cancers [4].	21.20	21.20	21.50	26.20	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.36	0.71	-4.10	12	144	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	40	0	69	136	0	129.30	42	89.78	CHANGED	MEs.pu.+KIQFoVPh.tspLDPcAsE.IRRRRPTPATLhhsS-pSSP..DE-psPp.htpsshphs.ppRpp.hshhsPohKtlQhlsEpHLpp.ushpEp.sp.tpp..sp.c.hs.sctpstpTpsp.....pSc.st.s.ppDups-s................G.pGshcpoh.ps.spccpsup....-Ps	..............M-s.ps.+KIQFsVPh....s.plsPctsE.......p........IRRRRPTPAoLhhhs-poSP..--ct.sp.......................hhp.p.ph..ppRhp.sshssPohK...tlQhhhpp.HLtp..tp....p.E..........................................................................................................t...................................................................	0	3	6	21
+5224	PF05396	Phage_T7_Capsid		Phage T7 capsid assembly protein	Finn RD, Moxon SJ	anon	DOMO:DM08648;	Family	\N	24.00	24.00	24.20	24.20	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.59	0.71	-3.97	6	46	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	41	0	2	42	65	122.10	41	41.72	CHANGED	spLSEtSYtcLttAGYS+uFVDSYI+GQEALV-QYVsuVlcYAGGpEpFsAIhsHLEusNPsAupSL-uAlps+DLATlKAIINLAGtShsKpFG+pPpRSlTpRAhP.ApPsAsp+...EGFuspu	..spLS--SYpcLAcAGYo+uFVDSYI+G.......Q...EA..........LVcpYVpuVh-YAGGcEpFstlhsHh.csp..NPssupuLssAlpspDlATlKAllNLustohscpFG+pspRsloppAhP.Ap..stpp...puFtsp...............................................	0	0	1	2
+5225	PF05397	Med15_fungi	GAL11;	Mediator complex subunit 15	Moxon SJ	anon	DOMO:DM07536;	Family	GAL11 or MED15 is one of the up to 32 or subunits of the Mediator complex which is found from fungi to humans [1]. The Mediator complex interacts with RNA polymerase II and other general transcription factors to form the RNA polymerase II holoenzyme [2], thereby affecting transcription through targetting of activators and repressors [3]. This family is found in fungi and the small metazoan starlet anemone.	21.60	21.60	21.60	22.80	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.33	0.71	-4.11	19	89	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	83	0	62	99	1	114.00	24	9.50	CHANGED	psp.hpp....l+plhpElu+ss.tLpslo..Los-pKstlpppLppspphhupV-sllshhahlopsccss+pLlQMRhhhKc.h....-ts.pGhallsP-hl-Klh.phpKaachh+tpl	..................................sp..chl+plhp-ss+sshphpsls..los-cKstlpppL..ppspphhupl-s.llshhh.hlspsEcsl+pLlQM+hhlpc.h....-....hhhps.hahls.-hlsphh.phpKaaphhhtph..............	0	16	32	54
+5226	PF05398	PufQ		PufQ cytochrome subunit	Moxon SJ	anon	DOMO:DM07133;	Family	This family consists of bacterial PufQ proteins. PufQ id required for bacteriochlorophyll biosynthesis serving a regulatory function in the formation of photosynthetic complexes [1].	22.10	22.10	22.90	22.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.57	0.72	-3.94	11	24	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	24	0	8	20	59	74.20	43	95.60	CHANGED	MoDhTossPhh....+s++sP+..sEFhlYFAlIFlsAlPhAhlsWhhsslRptolsp+GPlARAWspAchITPhIFuA	.MoDhssssPsp....+s++ss+...sEFhlYFAlIhluAlPlAhlsWhhsslRptplsc+GPhA+AWt-ActITPhIFpA.........	0	1	4	6
+5227	PF05399	EVI2A		Ectropic viral integration site 2A protein (EVI2A)	Moxon SJ	anon	DOMO:DM07597;	Family	This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumours [1,2].	25.00	25.00	40.70	40.70	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.63	0.70	-5.10	3	38	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	30	0	21	34	1	200.30	59	94.37	CHANGED	MEHKGH.YLHLAFLMTTVF.SLSsGT+sNYT+LWAsSsouWsSlsQNtT.SRN.PEsNNTNPlTPEVsaKuouTscPpTSsPVPLsSTSspchaTPSuspNSPsTup..tNTSKS+GETFKKEVCEENssNhAMLICLIIIAALFLICTFLFLSTVVLANKVSSLKRSKQVGKRQPRSNGDFLASsGLWPAESDTWKR.sKELTGSNLVMQS..oGVLTAsRERKcEEGTEKLT	..............McppG.p.YLHLAFLhTsla.SLSsGT+uNYTcLWssssosWs..sshQNto.u+s.sps.sTsPhTsp...ss.h+s..suTsh...s...p...o...u...t.....ss.LsspSp..........clhhPs.s.spNSssTsp..htsToKS+uElFKK-lCEENssphAMLICLIIIAVLFLICThLFLSTVVLANKVSSL+RSKQsGKRQPRSNGDFL.ASsGLWPAESDTWKR.sKpLTGssLhMQS..oGsLTAsRERKcEEuTEKLs.................................	0	1	2	7
+5228	PF05400	FliT		Flagellar protein FliT	Moxon SJ	anon	DOMO:DM07567;	Family	This family contains several bacterial flagellar FliT proteins. The  flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium [1].  	22.30	22.30	22.40	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.73	0.72	-3.58	109	993	2009-01-15 18:05:59	2003-04-07 12:59:11	8	1	913	12	186	524	21	83.70	30	72.78	CHANGED	hhpsuc.pscW.-plspLtpp.pppll.ptl.t..............tlsts.pppttphlcp....Ilsp-p......plpshhptphscLpptlpptppppphspsY	........................hLphAp.ctpW.-pLlt.Ehs.ahphl.ppltp................................s..sshopsh..pcphpshl+p....IL-N-p......pl+pLlQhRh-cLuphlspuppp+slhsuY................	0	37	94	141
+5229	PF05401	NodS		Nodulation protein S (NodS)	Moxon SJ	anon	DOMO:DM07274;	Family	This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.23	0.71	-4.92	7	251	2012-10-10 17:06:42	2003-04-07 12:59:11	6	6	221	5	103	7241	2646	154.90	30	58.66	CHANGED	opsssapLLpRELAA-DPWRLDuNsFEpcRHsQhLRLSLupGslusALEVGCAAGAFTE+LAPaCpRLTVIDVhPpAIsRsRpRhpc.uHISWlssDVpQFSosEhFDLIVVAEVLYYltDlsphRsAlcNLVpMLAPsGpLVFGSARDAsCpRWGHlAGAETVIuhLsEsLhEVERlcCpGsSssEDCLLu+FppP.uuS	.....................................................................t.hht................s....sDP.W..thp....p....p....h..Y.E....p.....c...+....h...t.......t....h...h.....h.h...s.....L..s...p...t...c....a....p...p....s........h..El...GC..u.s.G....t....L.....o....t...p.....L.........A....t....R.....C........s.......c.......L..........l...s......h....D....l........u.....s......p........A.....l....p......h.........A......+.......p.........R.......l............s.........s..............h.......s.........c.........l......p.......h........h......p........s.........s..........l..............s.......p....................h..........P..........p........t........p.............F........D........L.I...V....l....S....E....l...h....Y....Y...L....s.....s........h....s....c....L......p.....t....h....l.p.....p....h...h.t....t...Ls.ss.G.....p..l....l.......................................................................................................................................thhht...........................................................................	0	19	51	77
+5230	PF05402	PqqD		Coenzyme PQQ synthesis protein D (PqqD)	Moxon SJ	anon	DOMO:DM07172;	Family	This family contains several bacterial coenzyme PQQ synthesis protein D (PqqD) sequences. This protein is required for coenzyme pyrrolo-quinoline-quinone (PQQ) biosynthesis [1,2].	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.23	0.72	-3.96	330	1200	2009-01-15 18:05:59	2003-04-07 12:59:11	7	19	972	1	415	1109	164	72.60	20	58.04	CHANGED	s.phllls.ppth................h..............................pLstsushlac.hl.-..u..t.p...o..lpplsptLtpc.a.ssstp....h.ppDltpalppLtp...psllp	...............................................hlll..pthh.......h.......................pLspsushlhphl.-.....G..p..p..o..lspIsp.tLtpc..a..ssstp.......h.t...pDlhpalpplpp.pthl............	0	140	270	343
+5231	PF05403	Plasmodium_HRP		Plasmodium histidine-rich protein (HRPII/III)	Moxon SJ	anon	DOMO:DM07479;	Family	This family consists of several histidine-rich protein II and III sequence from Plasmodium falciparum [1,2].	45.80	45.80	46.30	45.90	45.60	45.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.65	0.70	-13.54	0.70	-4.76	3	1003	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	3	0	3	1004	1	117.00	75	96.41	CHANGED	MVSFSKNKlLSAAVFASVLLLDNNNScFNNNLhSKNAKGLNsNKRLLHEoQA....HssDAHHAHHsADAHH.........AHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAA.AHHAHHAADAHH...AHHAAD...AHHAAD...AHHAAYAHH...AHHAADAHHAAs.........AHHAADAHHAADAHHAAa.......uHpAHHAA......DAHHAsDAH...HtsDAHHsu.........sAHHAADAHHAADAHHAAc	.........................................................................AHH............AHHs..ADAHHAHHsADAHHAHHAADAHH...AHHAADAHH..A...HHAAc...AHH...AHHAAsAHH...AHHAAD...AHHAAc...AHHAA.AHH...AHHAADAHHAss...AHHAss..A...H...H...A...................................................................................................................................................	0	3	3	3
+5232	PF05404	TRAP-delta		Translocon-associated protein, delta subunit precursor (TRAP-delta)	Moxon SJ	anon	Pfam-B_7178 (release 7.7)	Family	This family consists of several eukaryotic translocon-associated protein, delta subunit precursors (TRAP-delta or SSR-delta). The exact function of this protein is unknown [1,2].	25.00	25.00	26.90	26.60	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.86	0.71	-4.80	16	146	2009-09-11 06:46:05	2003-04-07 12:59:11	7	4	109	0	73	146	0	155.00	43	90.57	CHANGED	hhth...hllslsluhsuupsCssPplp.sosYoToDAsIsophsFlsEFoLpCsN.GApsluLaA-Vs.GKlhPVsRssDsu+YQVSWs.EhKpApSGsYpV+haDEEuYuslRKAQRsGEDhsslKPLFTVsVcHpGu.apGPWlsoEllAsllshllhYhAaosKS+l.u	....................hhh.....hhhhhh..hhshss.u.csCtpPp.lo.sShYTToDAsIsocssFIsEhoLpCpN.sspshuLYA-Vs......GK......hPVsRupDs...s+YQ.VSWoh-aKpApuGsYpV+hFDEEuYutlRKAQ.R.ssEDls.slpPLFoVsVcH+.Gs.apGPWVsoElLAAhlulllhYhAFosKoplp.................................	0	28	32	54
+5233	PF05405	Mt_ATP-synt_B		Mitochondrial ATP synthase B chain precursor (ATP-synt_B)	Moxon SJ, Fenech M	anon	Pfam-B_7506 (release 7.7)	Family	The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport. It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L) [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.62	0.71	-4.78	31	515	2012-10-02 21:03:42	2003-04-07 12:59:11	9	8	409	4	214	1035	712	150.90	25	68.55	CHANGED	hhshhhSKclhlhN-EsllshsFluFlhhshKphusshsphhDschcplpsphpps+stphps.lpcpl-ptp.p.p.l.schspsLhpsp+-ssthptcstppptpstlspEl+s+L-ohlphpsshRph.QcclsptlhspVtpplss.sp...hpppsl...ppultplc	.....................hhhhhSpclhlhN-Ehl.s.uh.s.h.lu.h..h..h.h.s.h.K...p.h.G.s..s.h.p...phhDtphpplppphp..phps..sphps..lppph-p.t+..phpth...lph.p.p.h.lh...-...s.pc.......p...s..h.t.h..p...hp...t..t....p...p.....p..t...h...ltpp.lc...t...pLc.hh.l..p.h....ps.p....h........+..pp.Q.c...c...h...sp...h...l....h....t...p....Vt.p.phts..p.........ppphl....tpsls.l....................................................................................	0	74	110	169
+5234	PF05406	WGR		WGR domain	Bateman A	anon	COG3831	Domain	This domain is found in a variety of polyA polymerases as well as the E. coli molybdate metabolism regulator Swiss:P33345 and other proteins of unknown function. I have called this domain WGR after the most conserved central motif of the domain. The domain is found in isolation in proteins such as Swiss:Q9JN21 and is between 70 and 80 residues in length. I propose that this may be a nucleic acid binding domain.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.02	0.72	-4.02	109	1331	2009-01-15 18:05:59	2003-04-07 12:59:11	10	90	798	5	518	1209	72	76.20	28	11.75	CHANGED	st....hhhphsshs...p..sssKFYtlpl..h......t........hplhtcWGR..........lGss.GQpphc...sFs..s.ppA.hptap+lhpcKp..ppG....a..tp....t.pht	...................ht...........h....s...p...pspKFatlpl.........................s.......hplahpWG+...........................l..Gsp..Gp...s...plc.................sFs..sttpA.hcthtK...lht-Ks..+cG.atp.p....s..........................................	0	180	301	419
+5235	PF05407	Peptidase_C27		Rubella virus endopeptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C27. Required for processing of the rubella virus replication protein.	21.30	21.30	21.40	364.30	20.10	21.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.05	0.71	-4.53	5	69	2012-10-10 12:56:15	2003-04-07 12:59:11	7	2	10	0	0	71	1	166.00	98	11.55	CHANGED	WRCRGWQGMPQVRCTPSNAHAALCRTGVPPRVSTRGGELDPNTCWLRAAANVAQAARACGAYTSAGCPKCAYGRALSEARTHEDFAALSQRWSASHADASPDGTGDPLDPLMETVGCACSRVWVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHF	WRCRGWQGMPQVRCTPSNAHAALCRTGVPPRVSTRGGELDPNTCWLRAAANVAQAARACGAYTSAGCPKCAYGRALSEARTHEDFAALSQRWSASHADASPDGTGDPLDPLMETVGCACSRVWVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHF	0	0	0	0
+5236	PF05408	Peptidase_C28		Foot-and-mouth virus L-proteinase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C28. Protein fold of the peptidase unit for members of this family resembles that of papain. The leader proteinase of foot and mouth disease virus (FMDV) cleaves itself from the growing polyprotein and also cleaves the host translation initiation factor 4GI (eIF4G), thus inhibiting 5'-cap dependent translation.	21.10	21.10	21.10	21.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.28	0.71	-4.82	4	452	2012-10-10 12:56:15	2003-04-07 12:59:11	6	8	73	14	0	458	0	200.20	80	11.04	CHANGED	MsTocsahl...........lhtsF......hch+slF.s+hstphEhT..........uhPNpcsNCWLNuLhQLaphlD.s...........................LF-thYhsPtshTl-sIc.lp-.Ttl.-LpcGuPPhlVla.lppphpsslGTso+PpplClhsGs.hsLuDFaAulhhKs.pHAVFhhsTS-GWhsIDD-chYP.TPcscsVLs...........asPYD.EsLss-apcphtphLR	.......................................MNTTDCFIA...........LlaAl......REIKsLFLoR.sp..GKMEFTLaNGEKKTFYSRPNNHDNCWLNTILQLFRYVDEP...........................FFDWVYpSPENLTL-AI+QLEElTGL...ELHEGGPPALV...IWNIKHL.LaTGIGTASRPSEVCM.VDGTDMCLADFHAGIFLKGQEHAVFACVTSNGWYAIDDEDFYPWTPDPS.DV.L..V...........FVPYDQEPLNGEWKAKVQ++LK.......................	0	0	0	0
+5237	PF05409	Peptidase_C30		Coronavirus  endopeptidase C30	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C30. These peptidases are involved in  viral polyprotein processing in replication.	25.00	25.00	217.90	217.80	20.20	15.60	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.82	0.70	-5.34	5	594	2012-10-02 13:45:52	2003-04-07 12:59:11	8	34	208	139	0	625	0	291.30	52	5.41	CHANGED	GLWLGDpVYCPRHVIASsTohSsIDY-stLSllRLHNFSIsSss.sFLGVVSApM+GulLlLKVsQsNscTPKYoF+oV+PGESFNILACY-GsssGVYGVNMRSNaTIRGSFIsGACGSVGYNLcNGoVcFVYMHQLELGoGsHVGSDL-GsMYGGYEDQPslQlEussshhTsNVVAFLYAAIIN......GssWWLpSooloVEcYNcWAtsNGFTslsuoDAFohLAAKTGVsVE+LLcuIpsLNsGFGGKQILGasSLsDEFTPsEVl+QMaGVNLQSG+V+sh.....spsslhlhuFa	.GLWLsDsVYCPRHVIsosschssssYsclLsphssHsFpVt..s..sN...VpLsVlutpMpGslLhL..pVshuNscTPKYKFsplpPG-oFolLAsYsGsPsGlYtVsMRoNtTIKGSFLsGoCGSVGasl-t.ssVpFsYMHHLELssGsHsGTDLpGcFYGsahDppssQhsssDshhTsNVlAWLYAAl..IN......uspWFlp...ssosol-DFNhWAhsNuaosl....sss..s..s....lshLuAhTGluVpclLsuIpc.L.psGasG+sILGpssLEDEhTPt-VhpQhuGVpLQuphh+hl....hupphhhhh....h............	0	0	0	0
+5238	PF05410	Peptidase_C31		Porcine arterivirus-type cysteine proteinase alpha	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C31. These peptidases are involved in viral polyprotein processing in replication.	25.00	25.00	188.90	186.70	23.90	18.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.45	0.72	-4.17	3	229	2012-10-10 12:56:15	2003-04-07 12:59:11	8	8	11	1	0	264	0	105.00	92	4.26	CHANGED	L+WclPIuaPTVECoPuGsCWLSAIFPIARMTSGNHNFQQRLV+VAuVlYRDGpLTP+HL.+ELQVYERGCRWYPITGPVPGlALaANSlHVSDcPFPGATHVLTN	LRWTLPRAFPTVECSPAGACWLSAIFPIARMTSGNLNFQQRMVRVAAEIYRAGQLTPsVL.KsLQVYERGCRWYPIVGPVPGVuVaANSLHVSDKPFPGATHVLTN.	0	0	0	0
+5239	PF05411	Peptidase_C32		Equine arteritis virus putative proteinase	Studholme DJ	anon	Manual	Family	These proteins are characterised by a region that has been proposed to have peptidase activity involved in viral polyprotein processing in replication.	22.10	22.10	23.10	24.50	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.62	0.71	-4.43	4	221	2012-10-10 12:56:15	2003-04-07 12:59:11	7	9	12	1	0	270	0	127.60	80	4.95	CHANGED	sp+uC..L.t-.ss.-........G+CWhplF.sh.sh.stscEhchAspFGYQTptGVpGKYLtRRLQVpGLRAVsc..sGshlV.shts.pSWIRHlshAsEsV.ssF.clschcllPNsp....P.h.psp+hFRFGs+KaY	..........hQaGC..LPAD.TVPE........GNCWW+LF.DSLPPEVQhKEIRHANQFGYQTKHGVsGKYLQRRLQVNGLRAVTD.ocGPIVIQYFSVKESWIRHLKLsEEPSLPGFEDLLRIRVEPNTS....PLAsKDEKIFRFGSHKWY..............	0	0	0	0
+5240	PF05412	Peptidase_C33		Equine arterivirus Nsp2-type cysteine proteinase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C33. These peptidases are involved in viral polyprotein processing in replication.	25.00	25.00	29.30	39.20	19.90	17.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.63	0.72	-4.24	4	524	2012-10-10 12:56:15	2003-04-07 12:59:11	7	17	14	0	0	536	0	105.90	66	6.01	CHANGED	sYSPPuDGuCGhHCISAIhNchhsssFsTpLsppsRsss-WhSDpDLhQhl.shRLPATl...GtCPSApYhLchsspHWTVThRpG.hAsutLu.ECVpGVC.utEssl	.....YSPPAEGNCGWHCISAIANRMVNSsFETTLPERVRPSDDWATDEDLVNsIQIL.RLPAALDRNGACsSAKYVLKLEGEHWTVSVhPG.MSPoLLPLECVQGCC.EHKGGL....	0	0	0	0
+5241	PF05413	Peptidase_C34		Putative closterovirus papain-like endopeptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C34. Putative closterovirus papain-like  endopeptidase from the apple chlorotic  leaf spot closterovirus.	22.40	22.40	22.40	22.40	21.10	20.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.84	0.72	-3.93	5	13	2012-10-10 12:56:15	2003-04-07 12:59:11	6	2	6	0	0	13	0	92.00	74	4.88	CHANGED	KlKFIKGKaDCLFsSlAclI+KKPEEVMhFlPHlLDRCISNKGCSLDDLRuICpuYEIKVECEGDCGLlElGSlGLPLGRLlLRGNHFoVsS	.....KL+FIKGKFDCLFVSlAEIIHKKPEEVMMFlPHI....hDRClSN.+GCSLDDAKAICEKYEIKIECEGDCGLVECGo.GLSlGRMLLRGNHFoVAS.	0	0	0	0
+5242	PF05414	DUF1717	Peptidase_C35; 	Viral domain of unknown function (DUF1717)	Studholme DJ, Mistry J	anon	Manual	Domain	This domain is found in viral proteins of unknown function.	21.30	21.30	82.20	80.70	19.00	18.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.28	0.72	-3.56	2	9	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	5	0	0	10	0	83.60	67	3.87	CHANGED	sLlphllspD.S--LhssIEp...D+slSpchlE........cVhIhhG.ShlhhsD.hpMtslpht.GhsG+haC............pIKsscst.pS..tp	DLLNFLVNEDIS-ELL-CIEE...DKGLSHEMIE........EVLITKGLSMVYTSDFKEMAVLNRKYGlNGKMYC............TIKGNHCELSS....KE.	1	0	0	0
+5243	PF05415	Peptidase_C36		Beet necrotic yellow vein furovirus-type papain-like endopeptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C36. This protease involved in processing the viral polyprotein.	25.00	25.00	27.40	41.00	20.40	17.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.46	0.72	-4.14	2	8	2012-10-10 12:56:15	2003-04-07 12:59:11	6	2	4	0	0	10	0	103.90	76	4.92	CHANGED	NLlSRPNNCLVVAISECLGVTLEKLDNLMQANssTlsKYHsWLpKKoPSTWpDCRhFADALKVSMaVKVLSDKPYDLsY.VDGAuSslTLaLhGKESDGHFlAA	.NLVSRPNNCLVVAISECLGVTLEKLDNLMQANAVTLDKYHAWLSKKSPSTWQDCRMFADALKVSMYVKVLSDKPYDLTYEVDGAGSSVTLHLlGKESDGHFIAA...	0	0	0	0
+5244	PF05416	Peptidase_C37		Southampton virus-type processing peptidase	Studholme DJ	anon	Manual	Family	Corresponds to Merops family C37. Norwalk-like viruses (NLVs), including the Southampton virus, cause acute non-bacterial gastroenteritis in humans. The NLV genome encodes three open reading frames (ORFs). ORF1 encodes a polyprotein, which is processed by the viral protease into six proteins.	20.20	20.20	20.20	20.60	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	535	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.95	0.70	-6.21	5	408	2012-10-02 13:45:52	2003-04-07 12:59:11	7	5	351	10	0	397	1	490.50	74	30.25	CHANGED	K.DFSHIKLpLAPQGGFD+pGNTPaGKGsMKslTtuuLlARAsALlHERpDEFQLQGs...sYDFDcNRVoAF+pMAADNGlGllcsMRlGs+LKGVTTlEELKsALKsacIusCQIlYpGusYolcSDGKGuVsV-K...l.spssQsssElusAL+RLRsARARsYsSCsQ-llTSIIQlAGoAFVVsRtVKRh.............................chhu+PshGasttVsctutCEo....E-D--saphpspctcsEG.KKGKNKKGRGKK..asAFSoRGLSDEEYDEYKKIREERGGKYSI-EYLpDR-RYEEELAEscAsE-DFs-EpEhcIRQRlFhh+sTRKpRKEERupLGLVTGSDIRKRKPIDWsPsGsLWADD-RpVDYNEKIsFEAPPSIWSRIVpFGSGWGFWVSPoLFIToTHVIPsGspEhFGVPIspIsIH+SGEFs+FRFPKsIRPDVTGMILEEGAPEGTVsSVLIKRsSGELlPLAVRMGTpASMKIQGRlVsGQoGMLLTGANAKuMDLGThPGDCGCPYlYKRGNDWVVhGVHsAATRSGNTVIC	...........s.sDFSHIKLsLAPQGGFDKNGNTPHGKGVMKTLTTGSLIARASGLLHERLDEFELQGPsLTTFNFDRNKVLAFRQLAAENKYGLhDTM+VG+QLKDV+TMPELKQALKsISIKKCQIVYuGsTYTLESDGKGsVKVDR...VQSso...VQTNNELuGALHHLRCARIRYYV+CVQEALYSIIQIAGAAFVTTRIIKRh.....................NIQ.-LWSKPQVEsTEEsTsKDGCPK.....PKD...s..E.EFVIS..SDDIKTEG.KKGKNKsGRGKK..HTAFSSKG..LSDEEYDEYKRIREERNGKYSIEEYLQDRDKYYEEVAIARATEEDFCEEEEAKIRQRIF..RPT..RKQRKEERASLGLVT.GSEIRKRNP-DFKPKGKLWAD...DDRSVDYNEKLSFE.APP.SIWS..RIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPE.GTVsTLLIKRuTGE.LMPLAARMG.THATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAAARGGNTVIC........................................................................................................	0	0	0	0
+5245	PF05417	Peptidase_C41		Hepatitis E cysteine protease	Studholme DJ	anon	Manual	Family	Corresponds to MEROPs family C41. This papain-like protease cleaves the viral polyprotein encoded by ORF1 of the hepatitis E virus (HEV).	27.00	27.00	32.50	39.30	26.70	26.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.97	0.71	-4.69	4	183	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	14	0	0	193	0	150.30	78	9.88	CHANGED	AQCRRWLSAGFHLDPRVLVFDESsPCRCRThlRKsAuKFCCFM+WLGQECTCFLQPAEGlVGDQGHDNEAYEGSDVDPAEsAhhDISGSYlVsGRpLQsLYpALslPuDlsARAuRLTATVcVopssGRL-CcThlGNKTFpToFVDGApLEsNGPEQYsL	.AQCRRWLSAGFHLDPRVLVFDEusPCRCRoFL+KsAtKFCCFMRWLGQ-CTCFLpP.sEGhVG-pGaDNEAaEGS-VDPAE.AplslSGoYhVpGpQLpsLYpALsIPpDlAARAuRLTATVElususGRLpC+TlLGNKTFpTshsDGApLEANGPEQYVL............................	0	0	0	0
+5246	PF05418	Apo-VLDL-II		Apovitellenin I (Apo-VLDL-II)	Moxon SJ	anon	DOMO:DM08067;	Family	This family consists of several avian apovitellenin I sequences. As part of the avian reproductive effort, large quantities of triglyceride-rich very-low-density lipoprotein (VLDL) particles are transported by receptor-mediated endocytosis into the female germ cells. Although the oocytes are surrounded by a layer of granulosa cells harbouring high levels of active lipoprotein lipase, non-lipolysed VLDL is transported into the yolk. This is because VLDL particles from laying chickens are protected from lipolysis by apolipoprotein (apo)-VLDL-II, a potent dimeric lipoprotein lipase inhibitor [1]. Apo-VLDL-II is produced in the liver and secreted into the blood stream when induced by estrogen production in female birds.	20.10	20.10	20.10	59.90	18.70	17.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.87	0.72	-3.80	3	14	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	11	0	5	15	0	75.10	74	79.88	CHANGED	KSIFERD.RRDWLVIPDAVAAYIYEAVNKMSPRAGQFLlDlSQTTVVSGTRNFLIREToKLTILAEQMMEKIKoLWNTKVLGY	KSIFERD.RRDWLVIPDAlAAYIYEoVNKMSPRVGQFLsDsuQTsVVsGTRsFLIRETsKLolLAEQLMEKIKsLWYTKVLGY..	1	0	0	2
+5247	PF05419	GUN4		GUN4-like 	Finn RD	anon	Manual 	Domain	In Arabidopsis, GUN4 is required for the functioning of the plastid mediated repression of nuclear transcription that is involved in controlling the levels of magnesium- protoporphyrin IX.  GUN4 binds the product and substrate of Mg-chelatase, an enzyme that produces Mg-Proto, and activates  Mg-chelatase. GUN4 is thought to participates in plastid-to-nucleus  signaling by regulating magnesium-protoporphyrin IX synthesis or  trafficking.	21.30	21.30	22.60	22.50	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.88	0.71	-4.34	79	375	2012-10-11 20:01:00	2003-04-07 12:59:11	7	23	109	3	134	482	116	131.80	32	38.92	CHANGED	LpphLtspc.......accADcpTtpl..........hlplAsc.....p...pcsalhhs-lpshPspDLpoIDpLWlpYSpG+FGFSVQ+cIa.pul..Gss....................acpFss+lGW.+......ps......sp.....Wh..p....Y.sphs.a.....sls..APpGHLP...............h.hhsthhst.shtt	..................LpphLtptpaccADpcTtpl..........hhplusc................p.......pc..salhh.p-lc..p...h.PspDLpsIDpLWhpaS.pG+..FGFSVQpcIa.ppl..Gsp.............................appFss+l..GW..+..........pp..................sp.......W.h..p......a..sphsa...............sls......AP.pGHLP......sh.h...........th....................................................	0	20	91	130
+5248	PF05420	BCSC_C	BCSC_N; 	Cellulose synthase operon protein C C-terminus (BCSC_C)	Moxon SJ	anon	Pfam-B_10335 (release 8.0)	Family	This family contains the C-terminal regions of several bacterial cellulose synthase operon C (BCSC) proteins. BCSC is involved in cellulose synthesis although the exact function of this protein is unknown [1].	23.10	23.10	23.10	23.80	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.87	0.70	-5.32	29	686	2009-01-15 18:05:59	2003-04-07 12:59:11	6	129	625	0	98	549	12	338.60	55	29.89	CHANGED	hSpLsshpsPlpschPh..hsG+hhh+sssVplsAGohsss...............hspFGsssstsssst........................sQsssGlululGacsc....sapuDIGTTPlG.FphsslVGGlpassclu.s..huaslssuRRslTsSlLSYAGs+DP.................t..........o...GppWGGVspsGsphshoaDtGps.Glau.shuaphlsGcNVpcNpc..hchhsGhYhpllppscpp.lolGlshhhhpYc+N.uhaTaGpGGYaSPQpYhululPlpastRpsp.ao..aclpuSluhpph+pcusshaPtpshhpsth..........................sshasusSssGhu..YslpAtsEYRlusphhlGuslslppupsYs.spuhlYlRYshssh	.........................................................................Y.SDLKAHTTM.LQVD.APa..uDGRhFFRoDhVNMssGoFSTsu...........DGpacssWGTCTLpcCS.Gsc...............................................................................................SQuDoGASVAVGWcN-.......sWp..aDIGTTPM.G.FN..VVDVVGG.lSYScDIG....P...LGYTlNAHRRPISSSLLAFGGQKDu...........................s...........T..GpKWGGVRAsGsGlSLS..YD+GEANGVWA.SLSGDQLoGKNVEDNWR..VRWMTG...YYYKVIN.....pN.N....R.R.V...TlGLNNMIWHYDKDLSGYSLGQGGYYSPQEYLSFAlPVhW.RpRT.EN..WS..WELGuSsSWSHSRs+ThPRYPLhN..LIPsD.app...A...................scQossGG.SSpGFG..YTARALlERRVTuNWFVGsAlDIQQA.KDYsPSHhLLYVRYSAAG.W...........................	0	12	33	68
+5249	PF05421	DUF751		Protein of unknown function (DUF751)	Moxon SJ	anon	Pfam-B_10849 (release 8.0)	Family	This family contains several plant, cyanobacterial and algal proteins of unknown function. The family is exclusively found in phototrophic organisms and may therefore play a role in photosynthesis (personal obs:Moxon SJ).	21.40	21.40	23.00	23.00	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.82	0.72	-3.68	28	118	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	112	0	51	110	86	60.90	38	59.89	CHANGED	FasNVhRYPRYhIohhLGlhhshhpPlhsLh+p.PloulsllhhlluslhhlshsL+AMlsh	.FasNVsRYPRYhIohsLGlhhslhpPlhtLh.Ks.PloAlhlluhllushhhlhhsL+AMlG..........	0	15	36	47
+5250	PF05422	SIN1		Stress-activated map kinase interacting protein 1 (SIN1)	Moxon SJ	anon	Pfam-B_10677 (release 8.0)	Family	This family consists of several stress-activated map kinase interacting protein 1 (MAPKAP1 OR SIN1) sequences. The fission yeast Sty1/Spc1 mitogen-activated protein (MAP) kinase is a member of the eukaryotic stress-activated MAP kinase (SAPK) family. Sin1 interacts with Sty1/Spc1. Cells lacking Sin1 display many, but not all, of the phenotypes of cells lacking the Sty1/Spc1 MAP kinase including sterility, multiple stress sensitivity and a cell-cycle delay. Sin1 is phosphorylated after stress but this is not Sty1/Spc1-dependent [1]. 	19.40	19.40	21.80	21.00	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	523	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.56	0.70	-5.99	4	397	2009-09-11 11:45:00	2003-04-07 12:59:11	7	8	204	2	264	433	0	250.20	17	63.17	CHANGED	+lpoDDs.......GhC-hllls.Dh..................phc+.p.ss.sGGussphptop.................DLu-sp-ss.scsh-I..a.-hsh++.cssohpc.E+Lc..............................hu+psuh+hKs.shp-...phpssE.cphFp+pEl.........................................s.ssKsPhSuhpShLpcpLtcsstQhsN.htEau+FsGpup...sso++IslalPhpss.-...+..PLplplhsoA+lpElIGalhhQYs.pth-s.Lps...slstYsLalsEDDGEl-pDFPPLDsscPluKFGFosLuLVp+hptsssoppcp.hsh..hs+t...I..sN.ch.h+.h..pu.p.pcts.c.pts........hcYh.ptssp..ssl-lcsolpsAtshphshlpcNuuRuc..............................................................c-.p.phhshpDhhpu.happFhl.hhc.htF..+p-hpLuIsG-hlcI......ptSspha.p.KssSIsus.ls.hCclhEcp....Alh+hhh.pNpsoppasFts.uAshst.lss	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	82	134	215
+5251	PF05423	Mycobact_memb		Mycobacterium membrane protein	Moxon SJ	anon	Pfam-B_10885 (release 8.0)	Family	This family contains several membrane proteins from Mycobacterium species.	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.89	0.71	-4.44	7	764	2009-01-15 18:05:59	2003-04-07 12:59:11	8	2	115	0	144	501	0	124.40	29	72.34	CHANGED	hlKRhWIPLVIllVVsVuGhoV.RlHuhFGScppsohsss..psscPFNPKpVpYEVFGPsGThAsIsYhDssucPp+lsussLPWShslsTTLsAVhuNlVAQGsusSIGCRIhVsGsVKsERlssplpAaTaClVKSu	...............................................................s.........................................................s............shsP..+.pVsYEVhG..s..s..G..s..hs..s..lsY.h.....D.....s..s.u..ps...pphps....ssLPW..S..hsl..s...s..........s.........s.u....s.s.s...s.l..s..A..p..u...s.....u..s..s...l.sCRIo.V.s......GtVp.s.cp..s....p.t..ts.s.C...........................	0	21	83	126
+5252	PF05424	Duffy_binding		Duffy binding domain	Moxon SJ, Bateman A	anon	Pfam-B_11112 (release 8.0)	Family	This domain is found in Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade human erythrocytes that express Duffy blood group surface determinants. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa [1]. This family is closely associated on PfEMP1 proteins with PFEMP, Pfam:PF03011.	25.50	25.50	25.80	25.50	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.43	0.71	-4.46	409	7405	2012-09-24 07:47:50	2003-04-07 12:59:11	6	68	16	19	63	7892	0	148.80	32	63.35	CHANGED	GACAP.RRh+lCsp.NLE.pl.........s....s.p.......s.........h.........ps.............scsLLscVhh.uAKaEGpslhppa.s......pp.................s...............s......op...............lCTsLARSFADIGDIlRG+Dlapsssp...............pccl-psL+pIF...pcIhcplsst...............hpppYpt.s...s....sa.hpLREDWWssNRcp.............VW+AlTCsus...p.....s.s.p.YFpt..s..s.s...........ss.t.....s..s.....p.....p.cC.........pp..s..s.............s.......p.................sPT...hD....YVPQaLR	................................................................................................................................................................................................................................................................................................................................oh.hDIGDI.l..R....G...+........D......La.....huspt.......................+ccL.-cpL.....Kc.IF.p.p.Iapplppt...................hpt.Yt.s....s.......sa.hpLR..EDWWs.s.N.Rp.p..................VWc.AlTCsst....p....s.t....p...YF.+t.s..ss................tt.......p..s....p...p.pC......ts......t...........................t....p......................sP.T..h.D....YVP.QaLR...........................................................................................	0	56	57	61
+5253	PF05425	CopD		Copper resistance protein D	Finn RD	anon	Pfam-B_19002 (release 8.0)	Family	Copper sequestering activity displayed by some bacteria is determined by copper-binding protein products of the copper resistance operon (cop). CopD, together with CopC, perform copper uptake into the cytoplasm [1].	30.10	30.10	30.10	30.10	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.89	0.72	-3.83	210	1897	2012-10-01 21:57:53	2003-04-07 12:59:11	8	15	1406	0	513	1578	303	102.10	27	27.84	CHANGED	ttshpRF....uphuhhuV...ssll....loGlh.h....hhh.........................h...sshhs..osYG.....hhLhsKluLhlshhslushpRh.....hlhPpl......................tsspsht.tlpphltlEhslulslls...lsusL	.................h..shtRF....SthuhhuV.......ssll....loGlhs.u..hhh......hs.................h...sslhs...osaG......plLLhKhsLlhlhlsluhhs.Rh...............hlh.P+h................................................ttspsst.......h.hht.hs...t.l.E.hslus.llls...lsuh..............................................................	0	124	301	422
+5254	PF05426	Alginate_lyase		Alginate lyase	Moxon SJ, Mistry J, Murzin A	anon	Pfam-B_11800 (release 8.0)	Family	This family contains several bacterial alginate lyase proteins. Alginate is a family of 1-4-linked copolymers of beta -D-mannuronic acid (M) and alpha -L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyse the depolymerisation of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end [1].  This family adopts an all alpha fold [2].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  --amino -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.78	0.70	-5.04	59	980	2010-01-08 16:30:20	2003-04-07 12:59:11	7	39	535	10	303	910	259	247.60	17	47.74	CHANGED	slss+hth.ssussppDhhuts.ah......sstps............sshshhp+-Gph.........tphtsstpthtphupss.....tsLuhsathstpttastt..ssch.l+sWhlsststhpsplphup.........................h..h..h..pttsshsspp.pthcp.....Whsphhchhhs.t...tupsctstp......NNHuhWhshpVsuhAhhhscpchhchsh.......pp.htpshh.sQls.sDG...shPpEltR.............s+uhpYssasLtslshhAph....upp.tG...DLat....stsutslt+uhcalhsh..st.s.ppa	..................................................................................................................................................................tsht.h.p.stts.....hthuLtahho..s...pp...p..Yupt.......utch.l.......ps..W...hh...s...t..s.t.h.s.s.phphs............................h.t.l.ht...............hh.sh.hh.......psh.ssh.s..s.p..p.hpth.pp............ahp.p....h.hp.......h.hp...........ttpt..htt......................sNa.shhtshthhuhu.lhh....s....cc....s....h.hppul..............................................pt...h....ht...t....t....h..........s.p.....l.......t..............s......G...............pphtR...............................tpshtYsha...sLtshshhuph....utp...s.......Dla......s.psttl.htuhphhh.h..........................................................................................	1	102	191	258
+5255	PF05427	FIBP		Acidic fibroblast growth factor binding (FIBP) 	Finn, RD	anon	Pfam-B_19083 (release 8.0)	Family	Acidic fibroblast growth factor (aFGF) intracellular binding  protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF [1].	20.60	20.60	20.70	22.80	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.27	0.70	-5.22	7	124	2009-09-10 22:14:15	2003-04-07 12:59:11	6	4	87	0	83	127	1	291.70	43	86.60	CHANGED	ss-lDVFluNhTllD.ElYQLWl-GYoso-AVslhhppGhlcphGssuDlltSDshDHYRTaphlE+hLHtPsKLhpQ.hF.QlsPpppuhLIE+YYuhD-uhsREllGKKLSpts+KDLD-lupKTGlpLKSCRRQFDNhKRlFKsVEEh.GsLspNI+QpFlLs-cLAccYAAlVFhAs.RFETsK+KLQYLoFpDFhhCuptlhppWThsh.csts-..hDh-hDKEFL.DL+El+hLlsccc.l...KpLVshpL+sphh..sapEh-uNF+oh.RullsIAssLp+s+-lRshFlDLsEKhIEPh+tssWspppVphFhsphTpSVhsL-s.Rc....psLW-RYMtslpsCLh+MYHs	.........................................................h.s-lDlFluNhTllD.-l..YpLWl-GaSss-AVsh.hhp.....pG....h..h..pp..........h.....s.Ast...s.....lltSDshDHYRTFphl.E.+hLcsPsKLh..p.QhhF.QlsPpppthLIE+YYshD-shsRElLGKKLSptp+KD.........LD-lupK........TslpLKSCRRQFDNhKRlFKsV.E-....h................G..........s..LspNI.ppcFlLSc..cLA+cYAslVFhAs.RFET..sK+..K..LQYLoFtDhhhCup.hhp.WThsh.....................p...-......hDh-hD+-FL.-L+-L+.h.Ll...sccc.l...hKpLVshtL+s......h..l........shp-h-sN.F+.sh.RullslAspLp+s+-lRshFl....DLsE+hl-PhRpstWshpplphFLsthst.....s.s..hpl..-h..+c..............psh....Wc....RYMtsl.p.Cl.phYc......................................................	0	38	49	66
+5256	PF05428	CRF-BP		Corticotropin-releasing factor binding protein (CRF-BP)	Moxon SJ	anon	Pfam-B_11928 (release 8.0)	Family	This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor, allowing CRH to regulate both the adrenal and thyroid axes, especially in development. CRH-BP is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development [1].	25.00	25.00	25.30	25.20	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.95	0.70	-5.59	7	97	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	73	0	52	94	0	264.40	44	90.03	CHANGED	Mpsuucs.................phthl.L.lsshtupsRh.t.pssustshhhLhsuslpRE.p.-..a...hcChshhuh.G.aha.ust.t.sCuhalIuEPDpllpIchcpsslsCpsGshl...........................................................tlhDGW.LpGEhFPuppDH.LPh.cRhs-aCss......hss++hhRSSQNsAhl.aRl.s.GsuFohsVRhh.NshPCNllsQsspGhFTMss.tQtRNCSh.SllaPsslclssLplGt...pslthp..s.hsCtssGDhVElhGusGLDsupMhshuslChshss....sp.pIhCssosVRhVSoGpa.Npssh.hRphD..-h-hsp	..............................................................................................................t.p......t..aph.hcC.hphhuh.G..Fhahu.p.....ps.phhCuhahIuEP-phIplchc.lslsCps.Gshl...........................................................p.lhDGW.LpGEhFPSspDHsLPhp-RYhDaCss.................s.s++shRSSQNVAMlhFRltpsGsuFolol+p..N.hPCNllSQ..ossGtaThssstQ+RNCSa.SllYPsslplucLslGph............ps.lp..h...p....c......s.....hsCt..t...u..DaVElhGusGlDso.pMh.huslChshpss...sp.plsCssosVRhVSSG+a.NplohphR.l-..-lp...p............	0	10	15	33
+5258	PF05430	Methyltransf_30	DUF752;	S-adenosyl-L-methionine-dependent methyltransferase	Moxon SJ, Eberhardt R	anon	Pfam-B_12088 (release 8.0)	Family	This family is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase. It is often found in association with Pfam:PF01266, where it is responsible for catalysing the transfer of a methyl group from S-adenosyl-L-methionine to 5-aminomethyl-2-thiouridine to form 5-methylaminomethyl-2-thiouridine [1,2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.20	0.71	-4.45	17	1653	2012-10-10 17:06:42	2003-04-07 12:59:11	6	6	1635	15	373	1468	553	123.70	41	22.62	CHANGED	schtphtctLhppash...h.Ghhclths.stssLcLhhGDs.pptlspls....tpsDAWFLDGFuPs+NP-MWs.plhptluchscssGshuTaouAuhVR+uLhpAGFp.lp+p.GFGpKREhlpushs	........................................................pht.huppL.tpa....Phs.......hsG.....h.....a.Rl..hhs......t...scl.....sL.....-LhaG..D.h.pc.h..l.spLs....................tplDAWFLD......G.FAP....u.K...N..P...-.....MWops.....LFsthA....+L.u.+...s.....G..u...TlA..TFTu......A..G..h.....VR..RuLppAGFs.h.p.K.....t.+.GF.G.pKREMLpGhh.....................................	0	84	217	310
+5259	PF05431	Toxin_10	Toxin_P42; 	Insecticidal Crystal Toxin, P42 	Finn RD	anon	Pfam-B_19338 (release 8.0)	Family	Family of Bacillus insecticidal crystal toxins.  Strains of Bacillus that have this insecticidal activity use a binary toxin comprised of two proteins, P51 and P42 (this family).  Members of this family are highly conserved  between strains of different serotypes and phage groups [1].	28.60	28.60	28.70	32.90	27.80	28.10	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.40	0.71	-4.67	7	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	11	0	3	42	0	196.30	38	50.73	CHANGED	PphPp.sopLpshPcho...sIs.sGs.Pp.....lhG.TLIPCIhVsD.sI.shssphKpoPYYlLc+hQYWpphhuu..hlsstp+pohp.chGhspsppsohlsslshpIssD...thpF.....GstTssh+pQlsppLph.hSpssp.htchpcph-hsNsp.stshphstFlhtppapLhRhNGo.lps..hhshDpchhslpoYPs	......................PphPp..sppL.shPcho...sID..Gh.Ppps.pslhGtTLlPCIMV.sDssl....sp...ss+hKsoPYYllc+ppYW..pphhuu..lls....stpccohs.csGlscssQsoMhsslshpIGuD..hGh+F............GstTpsIKsQloc-LphphSpoop.htcpsEppEhsNss.shshpasuallsocapLpRssGoplps..hhshDpchhsltoYPp.............	0	2	2	3
+5260	PF05432	BSP_II		Bone sialoprotein II (BSP-II)	Moxon SJ	anon	Pfam-B_12103 (release 8.0)	Family	Bone sialoprotein (BSP) is a major structural protein of the bone matrix that is specifically expressed by fully-differentiated osteoblasts [1]. The expression of bone sialoprotein (BSP) is normally restricted to mineralised connective tissues of bones and teeth where it has been associated with mineral crystal formation. However, it has been found that ectopic expression of BSP occurs in various lesions, including oral and extraoral carcinomas, in which it has been associated with the formation of microcrystalline deposits and the metastasis of cancer cells to bone [2]. 	25.00	25.00	25.00	40.00	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.25	0.70	-5.13	4	53	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	33	0	23	49	0	263.80	57	94.51	CHANGED	FSMKNapRRAKhEDSEENGVFKYRPRYYLYKHAYFYPsLKRFsVQuuSDSSEENGsGDSSEEEtEEE.sSNEEtN...NE-S-uNEDE-uEAENhTLSosThGYGu-sTsGTusIGLAAlpLP+KAGshtpKusKc-ESDE-EEEEE...EpEEpEAEV--NEQusNGTSTNST.EVssGNGoSGG....DNGEE.GEEESVTEAtsEGTTVA.......u.TTss..sGhpsTTP.pElhGTTsPPhuKsTTst..GEYEQT.GspEY-ssYEIY-uENGEP.RGDsYRAYEDEYSYYKGRGY-uYsGQDYY	.........................FShKNhHRRsKlEDSEENGVFK..aRPRYYLYKHA.YFYPPLKRFsVQsu.SDSSEEsGDGs.S.pEEEtE.EE..TSNE.cEN.....NE-...Spt..NE..DE-..uEu..ENoTLSs...oT.uY.Gt.-sTsGsG.hGL.A.Al......plPKKu.Gt..htpK.us+p.cESD.E......-..EEEEE.....tENEcpEAE.VDENEQGlNGTSTNST.Es..-sGNGuuGG.........DsGEE..tEE.ESVTEAssEuT..Tss.......scTTssssuGapsTTPsp.ts...YtTTsP..PhtcsTTstYts.EYEpT...GsNEYDsGYEl.....Y-.sENGEP.RGDsYRAYEDEYS..Y...YKG+GYDuY-GQDYY...........	0	1	2	5
+5261	PF05433	Rick_17kDa_Anti		Glycine zipper 2TM domain	Moxon SJ, Bateman A	anon	Pfam-B_13382 (Rel 8.0) & Pfam-B_6 (Rel 24.0)	Family	This family includes a putative two transmembrane alpha-helical region that contains glycine zipper motifs [2]. This family includes  several Rickettsia genus specific 17 kDa surface antigen proteins [1].	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  --amino -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-9.09	0.72	-4.29	174	3882	2012-10-03 03:18:43	2003-04-07 12:59:11	10	13	1511	0	736	2475	469	41.70	44	28.29	CHANGED	hGshhGAssGulhGstl.ut......psthhusll.GAssGuhlGstlu	..............GsllGAlsGGllGspl.Gu.......GsGp.s..l.uTlu.GAlsGGlsGpplt...................	0	114	335	536
+5262	PF05434	Tmemb_9	TMEM9; 	TMEM9	Moxon SJ	anon	Pfam-B_12447 (release 8.0)	Family	This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9 Swiss:Q9P0T7. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localised to the late endosomes and lysosomes [1]. Members of this family contain Pfam:PF03128 repeats in their N-terminal region.	24.80	24.80	25.50	24.90	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.93	0.71	-4.46	6	196	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	89	0	107	165	0	131.20	46	75.14	CHANGED	PY+chsG+Iapp.........NVo.KDCNCLHVV-P...hPV.G+DVEAYCLcCECKYEERSooTIKVsIIIYLSllGhLLLYMlFLhllDPLL.RKhssao..lpo-E-s-DspPhssAtsslstuRucsNVLNRVEaAQpRWK+QVQEQRKoVFDRHshL	.......................................uplY.pp.........Nl.o..pc-......C...............sChcVV.cP....M.PV..GtD...lEAYCLhCECKYEERSosTIKVslIIaLollGhLLLYMlaLhLl-Pll...R+........sh.s.p.l..ps--...........-...........s..........tDt..ps.hss...............u...t....s........s..........sts...tu..ssVLp+V-htQpRWKhQVpEQR+slFDRHhhL...........................................	0	27	36	67
+5263	PF05435	Phi-29_GP3		Phi-29 DNA terminal protein GP3	Moxon SJ	anon	Pfam-B_14111 (release 8.0)	Family	This family consists of DNA terminal protein GP3 sequences from Phi-29 like bacteriophages. DNA terminal protein GP3 is linked to the 5' ends of both strands of the genome through a phosphodiester bond between the beta-hydroxyl group of a serine residue and the 5'-phosphate of the terminal deoxyadenylate. This protein is essential for DNA replication and is involved in the priming of DNA elongation [1].	25.00	25.00	449.40	449.30	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.70	0.70	-5.18	3	7	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	6	0	8	0	265.90	66	100.00	CHANGED	MARsSRIRITcNDKAEYAKLVKNTKAKIoRTKKKYGlDLSuEIslPsLESFcTREQFNKWKc+AESFTNRANpcYQFVKNcYGVVASKAKIsEIt+NTKEAQRlVDEpl-chcDKEaISGGKsQG.TVGQRhplLSPucVTGIuRPcDFDFsKVRTYuRLRTLEEuMccRosPsYYE++MpQLQpNFI+.SVEGSFNS..tADELVE+LKKIPPDDFYELFLhasEISFEpFDSEGssVEASEuhLpKI+SYL-cYcRGDsDLSLKGF	MARssRIRIpsNDKA.YA+LVKNTKAKIuRTKKKYGlDLosEI-lPsL-SFpTRtpFNKWKcptpSFTNRAN.pYQF.KNtYGlVASKAKIsEIt+NTKEsQRlVDEphcthcDK.ahuGGK.QG.TltQRhthhSPupVTGIsRPpDFsFscVRSYuRLRTLEEuMt.+ssPpYY-++MhQhp.NFIc..VEtSFNS..huDELlEcLKKIPPDDFaELaLhhsEISFE.FDSEGpsVEssEu.l.KIhSYL-pYcRGDhsLsLKGF	0	0	0	0
+5264	PF05436	MF_alpha_N		Mating factor alpha precursor N-terminus	Moxon SJ	anon	Pfam-B_12643 (release 8.0)	Family	This family contains the N-terminal regions of the Saccharomyces mating factor alpha precursor protein. All proteins in this family contain one or more copies Pfam:PF04648 further toward their C terminus.	21.90	21.90	25.30	25.50	20.00	18.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.85	0.72	-4.30	4	57	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	33	0	25	50	0	85.40	49	57.30	CHANGED	MKF.ohhoAsllAAsShsAs..ts.o---ou.pIPAEAlIGYLDLtGDhDIAVlPFSNuTssGLLFlNTTIsshApKEpussLsKRE	.........M+Fs.Slhos.hhhAAs.S.shAu..s.....t..spo--..-tA.....plPAEAlIGYLDLtGDpDlAlLPF..SNuTssGLLFlNTTIAptA....tc.E...ps...s.oLsKRE..............	0	2	12	20
+5265	PF05437	AzlD		Branched-chain amino acid transport protein (AzlD)	Moxon SJ	anon	Pfam-B_14345 (release 8.0)	Family	This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD is known to be involved in conferring resistance to 4-azaleucine although its exact role is uncertain [1].	22.70	22.70	22.70	22.90	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.19	0.72	-4.06	189	3465	2009-09-11 13:40:13	2003-04-07 12:59:11	7	2	2847	0	681	2161	1469	96.30	21	90.16	CHANGED	hhlhIlshulsTalsRhlshhlhtp.hplsshlp...phLphlPs....ulLsALlssslh.....hsttth......ssspll...Aslsshllshhp+.s....hlhollsGhsshhllp	......................hlhllhh.u.l...sTalhRhlPhhlhpp...h....t....h.s....s......hht...........thLphlPh.......ullsulhhsslh.............hst.t.t.................thspll..uhhsss.hlth.h..p+.s....ll.lsllsGhlshhll...................	0	196	408	553
+5266	PF05438	TRH		Thyrotropin-releasing hormone (TRH)	Moxon SJ	anon	Pfam-B_14384 (release 8.0)	Family	This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localised on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH [1]. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans [2].	27.80	27.80	27.80	28.40	25.30	27.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.17	0.70	-4.94	9	77	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	52	0	28	66	0	185.50	44	86.80	CHANGED	shlllLhuL.....sVstu.u....hQtpshsucspsuhD..-lLp+AEp.LLLRShLpphp--pst..ss....Qs-WlpKRQHPGKR.pc-.......................cKRQHPG+R--p........................tp.ts.hsp.+RQHPGKR..ht.....h.-pP...hhhS-loKRQHPG+Ral.....KRQHPG+RphcEEst..............lEKRQHPGKRh...........t.C-shsssGC..uul.L	..................hhl.lhhulh.s.hslstups....h.tps.httpt...-...lLppsct.lhLpp.lpphptcptt...st......t.pWlsKRQHPGKR.p--...................cKRQHPG+R--p.......................................s.s..htst.ss.pKRQHPG+R............sP....hLt.sloKRQHPGRRhlss...KtQ+shccct...--Epc..tthhs................EKRQHPGKRhh.........ssPCss.sssup..sth..............	0	4	6	13
+5267	PF05439	JTB		Jumping translocation breakpoint protein (JTB)	Moxon SJ	anon	Pfam-B_14502 (release 8.0)	Family	This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of JT. hJTB (human JTB) encodes a trans-membrane protein that is highly conserved among divergent eukaryotic species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the trans-membrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex) [1]. JTB has also been implicated in prostatic carcinomas [2].	20.90	20.90	21.00	20.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.77	0.71	-4.30	4	94	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	76	1	60	88	0	108.80	36	67.73	CHANGED	A-uPs+cEKlssppsspsCWhsEcFsVspECuPCSsFcI..Kohs..cChpTGYhE+lsCSsScps.hRSC.RSALh.Ep+.FaKFEsssssluLl.hhlshhRpRQL-R+sh.+lc+Ql	...................................h.p..ss..tsCWhh.EcasVspECpPCosFph..+ohs...tCspT.GYhEplpCs..sSc...p....h+S......C.Rsuhh.Ep+hFWKFEusshslull.shlVhhRpR.L-R+shp+lc+Ql......................	0	22	28	45
+5269	PF05440	MtrB		Tetrahydromethanopterin S-methyltransferase subunit B	Moxon SJ	anon	Pfam-B_15021 (release 8.0)	Family	The N5-methyltetrahydromethanopterin: coenzyme M (EC:2.1.1.86) of  Methanosarcina mazei Go1 is a membrane-associated, corrinoid-containing protein that uses a transmethylation reaction to drive an energy-conserving sodium ion pump [1]. 	19.40	19.40	19.40	54.20	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.26	0.72	-3.95	5	53	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	53	0	38	51	5	96.10	35	92.20	CHANGED	olV+IAPElsLVMDs-TGsVuctp.cDlIhlSM-PlaE+l-KLEulADDLlNSLDPSpPsLNSaPGREGVahhAGhaoNuFYGFllGLuIsuLLALIL	.........hVplsPEhsLVhDspoGlluptt.c-llhlohsPl.-plscL-phAD-LhNSLDPcss.lpSaPGREGshhhAGhhoshaaGFhlGLhl.hsLlshh.h.......	1	8	24	32
+5271	PF05443	ROS_MUCR		ROS/MUCR transcriptional regulator protein	Moxon SJ	anon	Pfam-B_1733 (release 8.0)	Family	This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti. This gene encodes a 15.5-kDa protein that specifically represses the virC and virD operons in the virulence region of the Ti plasmid [1] and is necessary for succinoglycan production [2]. Sinorhizobium meliloti can produce two types of acidic exopolysaccharides, succinoglycan and galactoglucan, that are interchangeable for infection of alfalfa nodules. MucR from Sinorhizobium meliloti acts as a transcriptional repressor that blocks the expression of the exp genes responsible for galactoglucan production therefore allowing the exclusive production of succinoglycan [3].	23.80	23.80	24.50	24.60	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.56	0.71	-4.38	127	729	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	320	1	355	661	38	123.90	40	78.76	CHANGED	tsstsllcLTA-IVuAYVS..sNslsss-LPsLIpsVasuLs..............slss...ss....t..ts.....p..................c.pP.AV......s..l+KSl.pPDhllCLEDGK.taKoL.KRHLpocaulTP-pYRpKWGLPsDYPMVAPsYAtpRSpLAKphGLGp	..........................................................s....thlpLsu-IVuAaVu..s..Nslsss-LPsLItpVasuLt......................................plstst.........t..........p.............................................................................p.pP.AV.....s.l+KSl.psDhIlCLEDGK.paKoL.KRHLto+ashT.P-pYRpKWGLP.s-YPMVAPsYAtpRScLAKphGLGp.......................................	0	93	242	268
+5272	PF05444	DUF753		Protein of unknown function (DUF753)	Moxon SJ	anon	Pfam-B_1957 (release 8.0)	Family	This family contains sequences with are repeated in several uncharacterised proteins from Drosophila melanogaster.	21.00	21.00	21.20	21.20	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.89	0.71	-12.93	0.71	-4.33	80	560	2009-01-15 18:05:59	2003-04-07 12:59:11	7	14	25	0	372	539	0	130.60	24	85.02	CHANGED	hpCsosp.s.ssC...tssshst.sppCpst.t......C.hotl........ssss.......htRGChscht........pssCsss.ts.....CpsC.su..s.sCNs.t.hstsR.hpCapCs....sssC....tssss.psphC.ha.....pts-p...Casph....ssshspRGChosh...............ppt..ssssppChh..Csss	............................h..Cpspp..s.sp..C.....ss.sh.hppCpst.t.......C.hohh..........ps.st............htRGChssl.t..t......tttCsss......t...sC.ttC...su....s.....tCNs..t.h.......stsp..hpChpCs......sssC.......ss....tst.C.hh.....t.tpt...Chh.h.....ts..h.hGC.sp..................................s.....................	0	48	79	267
+5273	PF05445	Pox_ser-thr_kin		Poxvirus serine/threonine protein kinase	Moxon SJ	anon	Pfam-B_1974 (release 8.0)	Family	\N	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.67	0.70	-5.69	9	74	2012-10-02 22:05:25	2003-04-07 12:59:11	6	1	50	0	0	102	4	427.40	67	96.40	CHANGED	ssh-tpa..hpspcps-TslLG.......DsIYFcalhSQlDhppsWu.Psl+ll+YF+s.Fs+psls+Iscp-YlNPSaFQ.KDcRFYPhNDDFYHlSTGGYGIVF+h.DcYVVKFVaEP.sppapPh-sTuEaTIP+FLYNNLKG...DE+cLlVCAhAMGlNYKlsFLasLY+RVLahLLLlhpIhDsp.Lsl.....paS++hhLKhFs-.+Kss.cFVKLlSYFYPhVlpSNlNVI..N.FsahhaF.......FEHEKRusYhY-RGNIIIFPLA+CSA-Klo.phstchGFt...........SlscYlKFlFLQluLLYIKIYELPsCsNFlHlDLKPDNILlFDS..pcslpIphsspsaVFcE.l+ssLNDFDFSQVusIh.NKKIKsSl+lE.pNWYYDFHF....FsHTLh+sYPEIp.pD.tFspuLpEahh..CpsKsTC-KFRL+VShLHPISFLtcFlt+s.lFSsWIN	............................................................................sss...EaQW..hSscchsDTVILG.......DslYFs.IhSQLDl+QsWA.PsVRLLpYFKN.FN+ETL.KIp-s-YINsSFFQQKDKRFYPlN.DDFYHISTGGYGIVFKI.DpYVVKFVFEs.sKhYS..PMETTAEaTVPKFLYNNLKG...DEKKLIVCAhAMGLNYKLTFLHoLYKRVLaMLLLLIQTMDGQcLSL.....+aSpKsFLKuFNE.RKDSIKFVKLLSaFYPuVIpSNINVI..NY..Fs+MFHF.......FEHEKRoNYp.Y-RGNIIIFPLAhaSA.DKVssEh..Al+LGFK................SLVpYIKFIFLQMALLYIKIYELPCCcNFLHsDLKPDNILLFDS...sEPIh.I.+lpc.ppFVFN...E.IKu.ALNDFD.....FSQVA.........uIl.NKKI.K.N......shKVE.HNWYYDFHF....FlHTLL..KTYPEIE.+DhEFosALEEFIM....C.oKosCDKaRLKVSILHPISFLE..KFIhRD.IFScWIN...................................................	1	0	0	0
+5276	PF05448	AXE1		Acetyl xylan esterase (AXE1)	Moxon SJ	anon	Pfam-B_4814 (release 8.0)	Family	This family consists of several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part of the xylanolytic system, together with xylanases, beta-xylosidases, alpha-arabinofuranosidases and methylglucuronidases; these are all required for the complete hydrolysis of xylan [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.90	0.70	-5.94	11	1046	2012-10-03 11:45:05	2003-04-07 12:59:11	7	10	743	111	195	2479	716	275.50	29	81.06	CHANGED	MtlhDhsLp-LppY+upsstPcDFs-FWspsLcEhpplsschcLppsDaplstVcsY-LTFsGhsGu+IcuhhlhP+.sctphPsllcFHGYsus.sG-hp-hLpasusGaushuMDsRGQG.....GtSpD.sssssussh.GahhRGlh-..t-phaYRcVFLDssphl-llhShspVDccRluVhGuSQGGuLALAsAALss+.lKtlls.YPFLSDFcRsh-lsh.pcsYpEltpYF+.hssp+E+EpclFpTLuYhDlhNLAcRlKusVLhulGLhDplCPPST.FAAYN+lpsc.K-lclYs.auHEshssa.p-phhpaLpcl	.............................................................................................................................htst....Pt.D.F-tFWpt.phpph...............p.....t..h........p......h...p..h..p.....h.....-..h....t....h...s........t.l..cs.a......c...l....s..a..p..u......h................t........s......s......p......lhuhl...h.h....P........c....................s.....p......t...t.........h......P..h...l.l....p........a..h...G............Y......h..s.................p.....t......h...................h....p.........h........l..............t..........a..........s....s..........t.....G.....a...u.s.lshDs......R..G..Qu..........................sho...pD......ts.........s...s..s....h.t......G...a..h.....h.......c...G....h....s..............-..p.h...a....a......+....c....l....a.........h......D.h.h.p....hl.-.h.l.t.s.h..s...p.....l...D...t.p......+........lushGs.SQG.G.ul.u...l.s.....s...u......u..........L..........s....s..........c.....l...pt......s...hs......h..P.....h...L......s...c....h..p..c.s...h.p....h..s.s........tt.s...Y....p..l..h...p...ah..p........s.....h.....p..t..p........t..phh.t.s..L..u.Yh.Ds..hph..A..p..+l.....p...s...s..h..h..sGh.DplC.......P.....o...aA....hYNtl.............s...s..............t......K...p...hh..l.h......huHtshtsh.....t.h......t....................................................................................................................	1	79	144	172
+5277	PF05449	DUF754		Protein of unknown function (DUF754)	Yeats C	anon	Yeats C	Domain	This domain appears to be found in a group of  prophage proteins.	25.00	25.00	27.70	29.70	23.30	21.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.71	0.72	-3.96	13	238	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	203	0	35	191	1	82.60	35	88.67	CHANGED	llsAllCusIslRL.lsY.RRsGARHRhhsShlAYlLslssGstslpllhu.....phtssuhhcshltslLslhVhpARGNVA+ll+ss	...........hlNshlCssIslpL.hhY.RR.s.suRHRshhSaLAalLhlshussPlphlhG.....ph.sssahtlhlNllhsshVlpARGNVu+lhc..t...	0	3	9	20
+5278	PF05450	Nicastrin		Nicastrin	Moxon SJ	anon	Pfam-B_15452 (release 8.0)	Family	Nicastrin and presenilin are two major components of the gamma-secretase complex, which executes the intramembrane proteolysis of type I integral membrane proteins such as the amyloid precursor protein (APP) and Notch.  Nicastrin is synthesised in fibroblasts and neurons as an endoglycosidase-H-sensitive glycosylated precursor protein (immature nicastrin) and is then modified by complex glycosylation in the Golgi apparatus and by sialylation in the trans-Golgi network (mature nicastrin) [1]. A region featured in this family has a fold similar to human transferrin receptor (TfR, Swiss:P02786) and a bacterial aminopeptidase (Swiss:P80561). It is implicated in the pathogenesis of Alzheimer's disease [4].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.59	0.70	-5.12	6	234	2012-10-02 19:46:12	2003-04-07 12:59:11	10	9	139	0	136	395	62	196.70	31	32.33	CHANGED	+lllVosRhDosohFcslulGA.SslsuhlslLuAAcuL....p+h.ss.Ss.p+NVlFlhFNGEoaDYIGSpRFlY-h-pGpFP.........stsIu.ssIDhhLElGsluptpu.t...hahH....utpspolsspsh-hLpphpcShuuss.tlh.sssssstlPPoShpSFLRcssshsuVlLssasspa.N+aYHSIhDcs-Nls.......................ps....s..thplsssAollAtuLY	.........................hlhsssphD..otoh.......F...........s.....l.....u.s..GAposluuhlshLusAcsL............pch......s...s.h.....s...p.h.........+...slhFs.hFpGE.sa......s.YlGSp....RhlaD...h.cp..s.phs........................................l....p.......h.......csI-...t....hlEls...pluht.ss.t........lahHss....s.t.ps...ps..h....tspl.ch...l......ssl.........ppu..h..shs.....s.h.hhh.......t...s...s...................lPP.o.S.hppFL+......t....p...........s......hs..u....ll.l.ssa..t.t.t.a..N.p.a.YpShhDs.p.tlt................................................................................................................................................................	2	50	74	112
+5279	PF05451	Phytoreo_Pns		Phytoreovirus nonstructural protein Pns10/11	Moxon SJ	anon	Pfam-B_15695 (release 8.0)	Family	This family consists of Phytoreovirus nonstructural proteins Pns10 and Pns11. Genome segment S11 of rice gall dwarf virus (RGDV), a member of Phytoreovirus encodes a putative protein of 40 kDa that exhibits approximately 37% homology at the amino acid level to the nonstructural proteins Pns10 of rice dwarf and wound tumour viruses, which are other members of Phytoreovirus [1].	19.70	19.70	20.00	20.40	19.50	18.10	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.08	0.70	-5.79	4	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	1	17	0	330.40	43	93.21	CHANGED	MDssT-phlpLHh-llspcpGapIlpKaDAI+KLpL....stcuspsNISpAAhsplppaupppEAYlASDLs-R-l.ssshhKAlIFVPtSVlssGK..KDLlPYGVlssslIaVPETholLDslp.hlsp...++PlSshllhchh+slph-VlGSsYDoaYYCssScYGKNLIKhusshPs.PpplRLSlsDLshsAhppsHshssphl.phhs+hPsGFpPKsHlL+I.hssh-MEhhcphVpp.huccP.stFpYsDppNlLpRTThFSsscsFSahILWRGW.STYKEhLSQDQlopFhtt.GsuGshssahhTaPShF-EGslYlpYcah...TP....put+uts.hPshsph	............MDs-TpRllpLHs-llppcpGapIloKaDAI+Kl+L....sssussNNlSpAALsKLpcaAspuEAYlsSDLs-Rsl.ssslhKAlIFss+SVlosGK.lKDllPYGVhsusllalPETholLDsI..hlupp..++PhohsllhphsKslph-llGssYDoaYYCsuStYGKNLl+husthPshPsplRLSlGDLsYhAApShHshAspYl.+lFs+LPsGFoP+SHLh+I.hslL-M-pFKchVpphhA+ps.stFpY-DsKNlLpRsshFSsDHpYotlILWRGWuSTYtEhLSQ-QlophpupsGhAGDLGhaphTlsShF-EGtVYlpY+Fh...TPt........ptsSt+utslYPsL.th........	2	0	1	1
+5280	PF05452	Clavanin		Clavanin	Moxon SJ	anon	Pfam-B_15887 (release 8.0)	Family	This family consists of clavanin proteins from the haemocytes of the invertebrate Styela clava, a solitary tunicate. The family is made up of four alpha-helical antimicrobial peptides, clavanins A, B, C and D. The tunicate peptides resemble magainins in size, primary sequence and antibacterial activity. Synthetic clavanin A displays comparable antimicrobial activity to magainins and cecropins. The presence of alpha-helical antimicrobial peptides in the haemocytes of a urochordate suggests that such peptides are primeval effectors of innate immunity in the vertebrate lineage [1].	20.90	20.90	21.20	28.70	20.70	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.81	0.72	-3.99	2	6	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1	0	0	7	0	70.50	82	100.00	CHANGED	MKThILILLILGLGIsAKSLEEpKu-EEKhh+hlGplIHtlGphVathuhshGDDQQDNGKFYGaYAEDNGKHWYDTGDQ	MKTTILILLILGLGINAKSLEERKSEEEKlF+hLG+IIHHVGNFVHGFSHVFGDDQQDNGKFYGaYAEDNGKHWYDTGDQ	0	0	0	0
+5281	PF05453	Toxin_6	toxin_6; 	BmTXKS1/BmP02 toxin family	Moxon SJ, Lee SC	anon	Pfam-B_16009 (release 8.0)	Family	This family consists of toxin-like peptides that are isolated from the venom of Buthus martensii Karsch scorpion. The precursor consists of 60 amino acid residues, with a putative signal peptide of 28 residues and an extra residue, and a mature peptide of 31 residues with an amidated C-terminal. The peptides share close homology with other scorpion K+ channel toxins and should present a common three-dimensional fold - the Cysteine -Stabilised alphabeta (CSalphabeta) motif [3]. This family acts by blocking small conductance calcium activated potassium ion channels in their victim [1,2].	25.00	25.00	41.20	40.90	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.59	0.72	-3.71	5	25	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	10	5	0	30	0	28.00	61	66.19	CHANGED	VGCEECPhHCKGKpAKPTC-Nu..VCsCNl	..VuCE-CP.HCpsKsA+spCDNs..hCsCps.	0	0	0	0
+5282	PF05454	DAG1		Dystroglycan (Dystrophin-associated glycoprotein 1)	Moxon SJ	anon	Pfam-B_15784 (release 8.0)	Family	Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and  [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear [1]. 	22.00	22.00	22.10	22.00	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.91	0.70	-5.23	4	207	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	101	1	85	198	0	192.60	39	30.30	CHANGED	shF+AhFsGDtptVhNDIpKKIhLVKKLAhuFGDRNoSoITL+sIT....+GSllV-WTNNTL...ppPCPc-Qlttlu++Ih-s-GpPRptFppulEP-a+hoNIoVssouSC+H..hpaIPh...c.IPotssss.sP-csscKSSpDDVYLHTVIPAVVVAAILLIAGIIAMICYR..KKRKGKLTl...EDQATFIKKGVPIIFADELDDSKPPPSSSMPLILpEEKsPLPPPEYPNpssPEThPLNQD.hGEYTPL+DEDPNAPPYQPPPPFosPMEGKGSRPKNMTPYRSPPPYVPP	.......................s..Fphhhthc..t...h...s.D..lpKKhhLV++LA.huaGDpssooITlpsI..o......pGoh..lVt..a.Nsol.......hp..Cs.cptlt.hht.ph.l.h.p..p.p....h.p.....p.th....p...s...h..tsp.a.hhphshh..upCpp.....h..s.......h..s....................s.tp....hh.l..slllhhhhl.l.ss.Ihhhhhp......h++pGK........................................................................................................................................................................................................	0	29	36	64
+5283	PF05455	GvpH		GvpH	Moxon SJ	anon	Pfam-B_16017 (release 8.0)	Family	This family consists of archaeal GvpH proteins which are thought to be involved in gas vesicle synthesis [1].	22.00	22.00	22.00	22.00	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.05	0.71	-4.64	4	26	2012-10-02 21:54:05	2003-04-07 12:59:11	6	1	22	0	14	71	7	161.80	22	91.78	CHANGED	.ssDDp........SDp.S...GLLDQLcsLlEsLAEIE.pEsG+ppspGpIDRGsARIDYDY-VSIGLGscuRsspss-tPss-sscsE.......phEpohHlETRssDDG.-lVVlADLPGVsD-c.lDVsL-sDpsALpl+scDcVVcRlsLDcPsspITshplpNQVLEIRLstos-opG.u-ss	...............................................................................s......................thhptlttllphLs.pl.t.pc.t......tp....hp..tpu..th....s....p..t...p.hphs....YsaslphG...lssc.....s...c........t...tt..t.s.hsp.t.csc..............p..tp.shc......l-...s+t.......p-Du.-ll.VlADLPGVsc...-c.lcVsl-s-pssLsl..p...s...s...c......c...h.l.c...RltL.s.p......s.s...c.ht..ph..shpNulLEl+lpttp.........tt.....................	0	7	13	14
+5284	PF05456	eIF_4EBP	EIF4EBP; 	Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)	Moxon SJ	anon	Pfam-B_5573 (release 8.0)	Family	This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1 ,2 and 3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryotic initiation factor 4F (eIF4F), which consists of three polypeptides, including eIF4E, the cap-binding protein subunit. The interaction of the cap with eIF4E facilitates the binding of the ribosome to the mRNA. eIF4E activity is regulated in part by translational repressors, 4E-BP1, 4E-BP2 and 4E-BP3 which bind to it and prevent its assembly into eIF4F [1].	20.20	20.20	22.60	20.80	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.40	18	197	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	97	16	104	192	1	107.00	47	76.84	CHANGED	MSu....upQ...SpSpuIP.oR+VhlpDsuQLPc.sYSoTPGGTLaSTTPGGTRIIYDRpFLLshRNSPlA+TPPspLPsIPuVTh.sss.hs..........pspppsppopshpsc.......--sQFpMDI	...........................tp...o.opsIP....oRplhl..pDssQLPp.sYuoTPGGT.LaSTTPG...GT.RII.YDRKFLL-pRNSPlupTPP.ppLPsIPGVTsPss...spp............t.pp...ptsp.ptt..........t.....--sQF-MDI....................................................................	0	30	41	66
+5286	PF05458	Siva		Cd27 binding protein (Siva)	Moxon SJ	anon	Pfam-B_5606 (release 8.0)	Family	Siva binds to the CD27 cytoplasmic tail. It has a DD homology region, a box-B-like ring finger, and a zinc finger-like domain. Overexpression of Siva in various cell lines induces apoptosis, suggesting an important role for Siva in the CD27-transduced apoptotic pathway [1]. Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis. Indeed, the unique amphipathic helical region (SAH) present in Siva-1 is required for its binding to BCL-X(L) and sensitising cells to UV radiation. Natural complexes of Siva-1/BCL-X(L) are detected in HUT78 and murine thymocyte, suggesting a potential role for Siva-1 in regulating T cell homeostasis [2]. This family contains both Siva-1 and the shorter Siva-2 lacking the sequence coded by exon 2. It has been suggested that Siva-2 could regulate the function of Siva-1 [3].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.22	0.71	-4.70	5	98	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	64	0	54	105	0	146.10	34	86.71	CHANGED	MPKRSCPFsDsAPLQLKVHVGQRELS+.GVsAERYoREIFEKTKQLLFpGAQAshD+lWsEGCuIsHpPEss+PG.TuAPc.AARGQMLIGPDGRLsRu.pAQASEAsPoG....sAshACSSCVRSVcuKusCSQCERAlCuQCl+s...CuuCuuLsColCTlsDau..DphEclLCoSCAhFEo	......................................................MsKR..Pat.ts.....QhKh+Vu.+plsp.GVhupph.pclaE..+ThpLLF.GApuh..htth.......tp....t....t......p..ps..t...s...th.p...hh.puQ.h.LlG.cG..cL...h..+s...spss.pss.ss...................ssh..s.CusC.h..R..s.ss.....s+...s.......sCupC-RslCspCsps...ChsCuslhCslCu..hs..shs...p...-pslC.sCt...........................................	0	15	20	37
+5287	PF05459	Herpes_UL69		Herpesvirus transcriptional regulator family	Moxon SJ	anon	Pfam-B_15401 (release 8.0)	Family	This family includes UL69 and IE63 that are transcriptional regulator proteins.	25.00	25.00	32.70	32.60	20.70	17.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.40	0.70	-5.19	30	149	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	84	1	0	145	0	212.20	31	39.51	CHANGED	tssttpploapcLlppsapLhppFptcshstphhpsl...Rctslpss.uLtshlAhsDEsLsWhKhphh+sLsl..pscD.IhsTusslhpsLhhKLpshh..pChLps........................................ps...thh+pLsph...................lpcps.pshps.lshslshlspaupsl.ttlpppshp......tltsh.spslpc.YpPGsshshlhpslpsHtppCssppCplthpthlsP..aspGhaFhss	............t...tttploa-pLhtpshtLhhpaphcshstphh+sh...Rphsltst.sLhphLA.sDETLuWhKhphh+s.LPl..pspDPlluTsuulhpsLhsKLpshh..tChLcs........................................ps.....lppLsch...............................hp+p..pshps.hphshshlsphuphl..slpphshp...............hltshsspthtt.YhPGsshshlhchLcsH.pcCps...chCcLphpphluP..YhaGhaFhs...	0	0	0	0
+5288	PF05460	ORC6	ORC6; ORC6_1; 	Origin recognition complex subunit 6 (ORC6)	Moxon SJ	anon	Pfam-B_16189 (release 8.0)	Family	This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins.  Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organisms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in [1].	20.60	20.60	20.90	20.80	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.19	0.70	-5.35	28	219	2009-09-11 10:55:20	2003-04-07 12:59:11	8	3	186	1	150	205	0	235.70	21	72.06	CHANGED	Lpcll........sphuts.hspcllshuspLhplSp..pppssltsppEluRshlCh.lAup...............+hppth..-lsh.hlch.PlpP+sap+hhshhcpsLtsps..........................................................t.s.t...................................................................................................................................................................................t..sh-lhplsspahlssplhs..ph.phhptacpphht....................p.httt...t...........phtstpppclp.hhslh..pthh....Wht.h..............p.....t.................................thGsMh.pspsha.hopc	.................................................tlh........sphu.s....pllptAppLhphSc....ppsuhhttppEhu+shhChclAsp.................ph.phsh........Dhs..hlphs..sls.+hYpphhphhcphLshss............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	25	71	114
+5289	PF05461	ApoL		Apolipoprotein L	Moxon SJ	anon	Pfam-B_16464 (release 8.0)	Family	Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.26	0.70	-5.17	21	365	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	72	0	177	313	0	241.10	27	74.16	CHANGED	psSpppL..LLTpccs.WppFVspAcLsR--s-sLhcsLtpLht.hshcDpsphp+s.pt...................................+chFL+tFPplKpcLc-pIccL+ALADplD+VH+ssTIoNVVuuSsussSGlLolLGLsLAPhTAGsSLsLoAsGlGLGsAAuVTuloTullEpsspstAcscAsclsssshsphcshtchltp.ssphhshsp.............shhpslcsltpsl+Al+hs+uNPpLs..usApphhssGplSspsupQVpcshtGTA...LAMo+sARIhGuAsuGlhLhhDVhsLVc-SKcLp-GAKoEoAEcLRphApELEcKLpcLsplYcsL	........................................................................................h..............................................................................................................................................................................tp.hFlp.Fsph+tcl....pp..pIpcLcslA-pl-chH+tssl.uslsuuSsu.ss.uG.lhollGLuLAPhThGsS.LhLou.sG..hGlusAuulTul..sosls-tsppppsptpspcl.hts.tppph.c.h..tp..h.htt.h.....thhph........................phh....p.....hpth...pphp.shp..hc.....h....stst.....h.ht...t.h.....s..............t......s...........p.......l..........tps.htsss..........hthspssphhshshsuh.lh....h....Dlh.ls.p.hcLtp.....G.u+sp.Attl+t.AtthpttL..h.t..t...............................................................................................................................................................................	0	41	58	83
+5290	PF05462	Dicty_CAR	Dict_CAR; 	Slime mold cyclic AMP receptor	Moxon SJ	anon	Pfam-B_16614 (release 8.0)	Family	This family consists of cyclic AMP receptor (CAR) proteins from slime molds. CAR proteins are responsible for controlling development in Dictyostelium discoideum [1,2,3,4].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.17	0.70	-5.53	6	214	2012-10-03 04:04:29	2003-04-07 12:59:11	6	7	115	0	165	697	4	215.50	19	52.21	CHANGED	hps.pEIcsoYulLLIADFoSIIGChlVLIGFWRLKLLRNHlTKVIoCFCsTSlhKDlhSTlLTLo....ssAsps.GFPCYLYAIVITYGSLACWLWTLCLAhSIYpLIVKREPEPE+aEKaYahlCWGLPLISTIlMLuKsslchVGNWCWIGspYsGYRFGLFYGPFFhIWulSAlLVGLTS+YTYpVI+NuVSDNKDKHhTYQFKLINYIIVFLlCWVFAVVNRIlNGLshFPsssNlLHTYLSVSHGFaASVTFIYNNPLMWRYaGuKllhlFThFGaFVEsQ+RLEKNKNNNNPSPhusS+uuo	.......................................................................................ttt..........................h......Sh..hu...s...hh.ll.hs.a...hh...p.......h+....p.............................+..h.l.h.h......h..s...h...ss...h...h....s...h....h......s...h....h..........h...................t....t......s......sh.......h.C...hQuh.h.....l.phh....u..s..h........h.....Ws.h...s..hA....hs...l...a....h...........s..h...h...p....p......s...p..h....c..+....h...c..h.....h....Y.h..l...h.s....a.G..l..P.h...l..s..s.....h...l.....h....h..............h.........t.....p......t......h......t..............h.......G........s....W..CW..l....p.........s...........p..............h.........s...........s..........h......R.......h....s................h.......FY.s...P.l..a...h....l......h....h....h.........h...h......h...h..h....h..................................................................................................................................................................................................................................................................................................................................................................hhhhhh........................................................................................................................	0	74	115	151
+5291	PF05463	Sclerostin		Sclerostin (SOST)	Moxon SJ	anon	Pfam-B_16740 (release 8.0)	Family	This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterised by a generalised hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients [1].	20.60	20.60	21.40	20.70	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.33	0.71	-4.83	4	114	2012-10-02 16:54:34	2003-04-07 12:59:11	6	3	45	3	56	111	0	177.90	50	95.52	CHANGED	hphsLl..LlClLh+uCh.........AFKNDATEll.uHs.tsh..cssNNuoLNpARNGGR+spss.hDpss.pQVGCRELRSTKYISDGQCTSlpPlKELVCAGECLPh.lLPNWIGGGa...YWSRRsuQEWRCVsD+TRTQRIQLQCpDGoT.RTYKlTlVTSCKCKRYTRQHNESSHs.pusSss+P........up+pRs+KRtuKsspppLo	..........................................hh..LhClLh+ush.........AFKNDATEIl.phs.ts................s.....ps......p....s..NsT..h.Np.AcNGGR..p....ps.....h-p.p.st.sphuCRELRST+YloDGpCpShpPlKELVCuGpClPh.lLPN....h.IGtGh.....W.Rpsu.p.-aR.Cl.sD+oRTQRlQLpC.sGss.RTYKlplVTuCKCKRaTRpHNpSph.p.....uhpsu+P........sp+..+..+t+suKsspt.........................	0	6	11	23
+5292	PF05464	Phi-29_GP4		Phi-29-like late genes activator (early protein GP4)	Moxon SJ	anon	Pfam-B_16889 (release 8.0)	Family	This family consists of phi-29-like late genes activator (or early protein GP4). This protein is thought to be a positive regulator of late transcription and may function as a sigma like component of the host RNA polymerase [1].	21.60	21.60	22.10	222.80	19.60	20.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.46	0.71	-4.24	3	7	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	8	0	8	0	125.40	73	99.32	CHANGED	MP+TQRGIYHNLKESEYVlS..NGDVTFFFSSEMYhNKFLDGYQEaREKFNKKIsRlscT.PhNMDMLADITFYSpVEKRGFHAWLKGDNsTWQElHVYALRpMTKPsTLNWSRIpKPKLRERRKSMV	MP+TtRGIYHNLKESEYVsS..NsDsTFFFSSEhYLNKFLDGYQcaRccFNKKIpRlssT.PhNMDMLADITFYSpVEKRGFHAWLKGsNsTWpElHVYALRhMTKPsT.sWSRIpKPKLtERRKSMV	1	0	0	0
+5293	PF05465	Halo_GVPC		Halobacterial gas vesicle protein C (GVPC) repeat	Moxon SJ, Bateman A	anon	Pfam-B_17013 (release 8.0)	Repeat	This family consists of Halobacterium gas vesicle protein C sequences which are thought to confer stability to the gas vesicle membranes [1,2].	22.30	22.30	22.70	22.90	21.80	22.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.34	0.72	-3.95	29	50	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	7	0	20	45	0	32.00	32	48.53	CHANGED	VssLhssIsshcppassspsuFcsYu--Fsss	..VssLhssIsshcpphssspsuF-uYu--Fss.......	0	10	14	20
+5294	PF05466	BASP1		Brain acid soluble protein 1 (BASP1 protein)	Moxon SJ	anon	Pfam-B_16137 (release 8.0)	Family	This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of unknown function [1,2].	25.00	25.00	77.60	48.80	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.10	0.70	-4.54	6	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	28	0	28	49	0	175.80	58	98.29	CHANGED	GGKLSKKKKGYNVNDEKAK-KDKKAEGAuTEEEGTPKEs..EsQAAsEoT.EVKE.spEEKP-KDApsotsKsEEKEGEK-AsssKE-A.KAEPEKoEuuA-AKsEPsKs......sEpE.AAAsuPAsuuEAP..KAuEsS.....stsAEuAAPup.--.SKEEGEAKKTEAPAu.AupEsKS-uAP.ASDSKPSSsEAAPSSKETsAATEAPSSTsKApsPAAPA-EsKsuEuP..AANSDQTVAVpE	.........GGKLSKKKK.GYNVNDEKAKDKDKKAEGAusEEEsTPKEs..EsQsAu-ss.EsKE..tcpKs-pDups...KsE-KEu-K-ss.spE-s.KuEsEK.oEu..s-upsEP.ts......scpp.tAssuPusss-As..Ks.sEst.......su-s.Asst..p.u+EpGEsKKTEAPAs..hpEsKS-sAP.ASDSKPuSsEAAPSSKET.sA....TEAPSST.sKA..tP.u...uss-p...sEsP..ssNS-QoluVp-..................	0	1	3	9
+5295	PF05467	Herpes_U47		Herpesvirus glycoprotein U47	Moxon SJ	anon	Pfam-B_17115 (release 8.0)	Family	\N	25.00	25.00	80.50	80.00	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	677	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.45	0.70	-6.68	2	53	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	7	0	0	25	0	119.00	85	96.88	CHANGED	MLHISpLGLFLuLFAIVMHSsNLIKYTSDPLEAFKTVNRHNWSDEQREHFYDLRNLYToFCQpNLSLDCFTQILTNVFSWsIRD.QCKSAVNLSPLQNLPRsETKIVLSSTAANKSIlASSFSLFYLLFATLSTYTADPPCVELLPFKILGsQLFDIKLT-ESLpMAhSKFSNSNLTRSLTsFTsEIFFNYTSFVYFLLYNTTSCl.SNDQYFcpSPKPINVTTSFGRsIVNFcSILTTTP....SSTSASlTSPHIPSTNhPTPEPsPVTKN.TcLpTDTIKVTPNTPTITsQTTESIKKlVKRSDFPRPMYTPTDIPTLTIRhNATIKTEQNTE....NPKSPPKPTNFENTTIRIPcTFESsTVsTNsTQKlESTTF.TTIGIcEIssNhYSSPKNSIYLKSKSQQSTTKFTDsEHTTPILKFTTWQssARTYMSHNTEVQNMT...................................................DRFQRTTLKSSsE.PTlQTLSVTPKpKLPSNVTAKTEVplTNNALPSSNSSaSITcVTcEsKpsRMSASTHtEINHTEIsphTPILNAHT.EKSTTPQhsFTAET.LTTSSKsAILTWSNLL.TTPKEPLTNTSLR.TsHITTQLTTSNRTQSAKLTKAplSSQTTNIYPQTITtRST-V	...........................................................................................................................................................................................EESLRMAMSKFSNSNLTRSLTSFTSKNFFNYTSFVYFLLYNTTSCVPSNDQYFKQSPKPINVTTSFGRA..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+5298	PF05470	eIF-3c_N	eIF3c_N; 	Eukaryotic translation initiation factor 3 subunit 8 N-terminus	Moxon SJ	anon	Pfam-B_17447 (release 8.0)	Family	The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170 kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA [1].	20.70	20.70	20.80	20.90	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	595	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.99	0.70	-6.43	8	593	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	302	0	373	561	13	373.20	28	67.47	CHANGED	+ahpssssp-usDEEDsKRVVKSAKDKRFEEhssslcpI+NAhpIsDhlslppsFDcLsKthpKsh....hp-sstsPshYI+sLstLEDaLNch.ssK-uKKphSpuNuKALNoh+QKlKKsN+..paEDcIs+aRcsPEp-s-cssE---s-ssGssspscs.ssshtsp.lst.....s.pu.................................................................................t....t.tst......hs...h..c.hhhpcscEITassVhKKLpEIhsARGKKsTsRp.......pplcpLpcLscIAcpssp....plcIhFslISApFDlNs.slSsaMPI-hWppslpshpolLDILltsssIhls.phsDpsE..Ep-spc..shsGslRVpGslluFlERlDsEFhKSLQsIDPHos-YVERLKDEsphhsLlpplQcYlEcpGcs.....+sss+lhl+RlE+lYYKscplhch.......................pptt..ss.hsshchssct.shs-sScsLMDtLsshIY.Ksss-Rl+sRAMLCcIYHHALpDcFhpARDLLLMSHLQ-NIpHhDluTQILaNRTMsQLGLCAFRtGhlpEuHpsLs-LhSouRlKELLuQGl.tsR.HE+TsEQE+lERpRQ.lPYHMHINLELLEsVYLsCAMLLEIPpMAAspaDA	.....................................................ht.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h......................................................................................................................................................................................................................................................p..t..............h.........................................................................................................................................................................................................ht.h....l.........t..t.....t.tuhL..h.a..uh.tpa..u+-hhh.uth.p.h..........-...p..............lhaNRhhsplGlsAF+.s.h.cspthL.-l......t.t+...........+-.ll.uQt........................t...s.pt...............ph.c+th..hPhH.Hlsh-ll-.h.hhsuhhl-ls..s.......................................................................................................................................................................	0	131	215	314
+5300	PF05472	Ter		DNA replication terminus site-binding protein (Ter protein)	Moxon SJ	anon	Pfam-B_17662 (release 8.0)	Family	This family contains several bacterial Ter proteins. The Ter protein specifically binds to DNA replication terminus sites on the host and plasmid genome and then blocks progress of the DNA replication fork [1].	22.00	22.00	22.00	23.20	21.10	21.90	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.78	0.70	-5.29	23	673	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	604	5	60	325	12	282.80	59	95.91	CHANGED	pclsspFcplppcLttLpptLsstphltA+VaslPsVt+spE+.cslspItVpphhGppAhshulctapclaIp.....pshSoKushRhPGllshsssstp...plhshIscINplKsshEplIsspss.spptRF..............EhVHpp.LPGLlTLpsYRplpslp...s.solRFuWtp......K+sl+sho+..cclLttLcKuhpssttssshs.cppWpttlspEhpplsp..LPpcspL+I+RPVKVQP.lAplaa.....psp.......pcphphssshPlIsl.....sspsPclspL.hsYDssshp....+h+spttshclLls..RLHlYh	......................................................................RLNsTFRQhEQcLAshsspL.pQap...LLlARVFSLPpVpK-sE.....H..sPLs....pIcVp.QHLG.p-ApsLALRHaRHLFIQQ....................QSENRS.SKAAVRLPGVLCYQ..VDNhoQ.tsLhspIQ+INpLKT....TFEclVTVES....t.....LPoAARF...........................EWVHRH..L.P.G.LITLNAYRTLTlLp...sPATlRFGWAN......KH.I.IKNLpR..DEVLuQLEKSLpSP..............RS.VsPWT.REpWQpKLEREYQDIAA...........LPQpA+LKIKRPVK....VQP.IARVWY......KGp........QKQVQHACPTPLIALINpDNGAuVPD.lGEL.hNYDADNlQH...RaKPQAQPLRLIIP..RLHLYV................................................................	0	6	18	36
+5301	PF05473	Herpes_UL45		UL45 protein	Moxon SJ	anon	Pfam-B_17674 (release 8.0) & Pfam-B_16138 (release 10.0)	Family	This family consists several UL45 proteins. The herpes simplex virus UL45 gene encodes an 18 kDa virion envelope protein whose function remains unknown. It has been suggested that the 18 kDa UL45 gene product is required for efficient growth in the central nervous system at low doses and may play an important role under the conditions of a naturally acquired infection [1]. This family also contains several Varicellovirus UL45 or gene 15 proteins. The Equine herpesvirus 1 UL45 protein represents a type II membrane glycoprotein which has found to be non-essential for EHV-1 growth in vitro but deletion reduces the viruses' replication efficiency [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.35	0.71	-4.89	11	167	2012-10-02 16:37:33	2003-04-07 12:59:11	7	22	100	0	44	725	1	141.50	17	27.58	CHANGED	osospsptPLsshcs...h.............suspspRs+p.s.sss.......................hhhshhslGlllTshlllushl....hslPhsuhpsusCPspWhGlssuClRssspss.....spppAsssCuthsupllspusAptLhsllsshusssus.h.....................hssDultsClpsstussh..p..CspsuhsIC.tsRslSshuphIhcsRpuLpL	.................................................................................................................................................................................................................................hhhh...s.h..h......hsh.....h..l.....h........s...hl.....................h....t..........s.............t........s....h......t....t.......t..............CPpc.Whsa...s..s.sC.h.thss.sst............sappApshC.p.s..h..s.....u..p...l...h...s.......s......s..................h..........hh.t.............................................................................................................................................................................................................................................................................	0	11	14	33
+5302	PF05474	Semenogelin		Semenogelin	Moxon SJ	anon	Pfam-B_18147 (release 8.0)	Family	This family consists of several mammalian semenogelin (I and II) proteins. Freshly ejaculated human semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicle secreted semenogelins (Sg) [1].	19.10	19.10	19.10	19.10	16.90	16.00	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-13.19	0.70	-6.22	4	125	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	26	0	7	129	0	273.00	43	97.46	CHANGED	MKPIIhFVLSLLLILEKQAAVMGQKGGSKGQLsutSspFPatppu.pYSu.KDKQHsESKGShSIpHTaHVDspDHDpTRKSpQYDLNAQpKTTKScpa.tGpQELhNaKQEGR-+uKsKscFHhlVIHHKGGpspHGTQNPSQDpGNSTSGKGh.SQ.SNTcEpLhspGLuKEQsSsSGAQ+sRTQGGSQSShVLQTE-.Vs....NKQp.ETQNShpNKGpY.NVhEs+pcHSSKlQTSLasAppcRLQHGSKDlFo.........KNQ+QT+NhNQDQEHGQKAHKtShQsSST............................................................EERRLsauEpGIQKDsSKuShSpQTt-KhhsKSQpQlThPSQ-p..up+tNKhS.QSSusEERR.p.GEpGlQKsVspuph..pTE-KIHsKsQNQlTIPSQDQc........................................................................................................................SGQsAKGpSGQSsDREpDLLS+EQKsRHQctspGuhNlVIIEHEsspD++.sQ++spDpNslsT	.............................................................................................S.h.lphhaHs..pstD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	3	4
+5303	PF05475	Chlam_vir	Chlamydia_vir; 	Chlamydia virulence protein PGP3-D	Moxon SJ	anon	Pfam-B_18238 (release 8.0)	Family	This family consists of Chlamydia virulence proteins which are thought to be required for growth within mammalian cells [1].	25.00	25.00	31.10	31.10	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.63	0.70	-5.28	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	20	0	1	29	0	207.60	73	99.67	CHANGED	MGNSGFYLpNTQNCVFADNIKVGQMTsPLKDQQlILGTTSTPTAAKhTAc-GIslTs-ossSTNASITlSLDuEAlhK....LIL-QIpD-LVcuIIcNITsSLIQEVIDKIpoDPSLuLoKAFKNFsITNKIQCNGLFTKcNIGTLLGGTEIGoFTVTPDNAsSMFLISADIIASRMEGsVVLALVKEGDSuPCAISYGYSSGlPNlCSLRTsVuNoGssPVTFSLRVGGMESGVVWVNALuNG-cILGlTsTSNISFLEVKPQTNG	.........MGNSGFYL.sTpNCVFADNIKlGQMppPLpDQQlILGTpSTPsAAKhTAs-GIslTlSNssusNASIsluLDAEpshp....LIL-pltcpIlDuIhcsIssShlQ-llDKIpoDPSLuLhKAFpNFsITsKIQCNGLFTsSNItTLLGGTEIGKFTVTPcsusSMFLlSADIIASRMEGsVVLALV+EGDopPCAISYGYSSGlPNlCSLRTslpNoGhsPsTaSLRVGGh-SGVVWVNA..LuNGssILGhTsTSNlSFLEVh.QTNu.	0	0	0	1
+5304	PF05476	PET122		PET122	Moxon SJ	anon	Pfam-B_18328 (release 8.0)	Family	The nuclear PET122 gene of S. cerevisiae encodes a mitochondrial-localised protein that activates initiation of translation of the mitochondrial mRNA from the COX3 gene, which encodes subunit III of cytochrome c oxidase [1]. 	22.30	22.30	22.50	22.60	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.86	0.70	-5.14	5	30	2009-09-10 15:37:49	2003-04-07 12:59:11	6	2	29	0	15	26	0	249.50	45	89.80	CHANGED	MLlIsRRLVsT.-VR+RLYspCLNt-hsulLspLRQIsVscMDhSLLpLhLs+SspaGHl-oIsYlWYKYVhRH+.LhVEP+LLCDIuslALtQGKLFIPuQlLpHYQsh.YG+Gppt...sEhppaEYELpRIKVEuFAKGTMcsToFsEKWKVFLQ-MDpTLPuss.aclRDFPaLT+A......LhQTDEps......htphLFu-pclsVsNcoSLPLLLNhVLLQ.ssFsL-sRlRlFpcFhpoYRuLPlpDolEIlIK+s..psYh..cLhphl....RGhEIsT	...................s+Rhlos.DlRpRllLssLNtchs-ALshLRpp..ppsshDspLLpshLARAsthAHs-oIsYhWYpaVM.++.LsVcs+LLC.-MAslALap-+hFLPuQhLpHYpsh.hc++ss....sEp-hlEYELhRIKVEuFA+GTMcuTuhREKWKVFLQ-MD.o.....LPupsshRlRDFPphTKu......Lh.ppDEps......huhhLFsc.p.lsIKNcaSLPLLLshlLhp..s.hssps+.+lhtcFh.p...oY+uL..s.L.hDu.pllh+c......cGacl..................ss..................	0	1	6	12
+5305	PF05477	SURF2		Surfeit locus protein 2 (SURF2)	Moxon SJ	anon	Pfam-B_18437 (release 8.0)  	Family	Surfeit locus protein 2 is part of a group of at least six sequence unrelated genes (Surf-1 to Surf-6). The six Surfeit genes have been classified as housekeeping genes, being expressed in all tissue types tested and not containing a TATA box in their promoter region. The exact function of SURF2 is unknown [1].	25.00	25.00	28.60	28.60	20.30	21.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.77	0.70	-5.24	8	115	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	75	0	69	99	2	210.00	30	81.53	CHANGED	McElPpDV+uFLppHPsLcLs.-up...KVRChLTGHELPCpLsELQsYTcGKKYp......+Lspupss..FsYspaEPHIVsSTKs.pQLFCKLTLRHINKpPEHVLRHlpGKRYQ+ALppYE-CpcpGVcaVPApLhpKp+.+c...spcsuscpP.p+p-s.......hWtPsS....S-E-sutS-DSMoDLYPsphFs.Ks.sp.ps.t....t.-sFpTD.c-....--hthcspp.p...............pKRu...KKQsuuhpKKFKpsH+Kspphp.uSsK	..................................phtthLtppP..hph..sss.......+l+CtlTGHElPsp.hs-lpsYscuKKYp......+.L...p...s..p..p..hs.aspa-PHll..s.ss..c.p...ppLaCKLThcplNKpsEHlh+HlpG+Rap+tLpchEcspp..p..G....h.chh.....up...h..p........c.tp..p.pp.........pp.ss.st.....t.ppt......................hW.P.s......scpp....t.scDs.....hsDh...hss..t.h...tp.t.ttp....t.........................t.psh.....sc.....pp.......ccht......t...........................p........t.......t..tpc.p...............t.....................................................................	0	25	37	53
+5306	PF05478	Prominin		Prominin	Moxon SJ	anon	Pfam-B_18226 (release 8.0)	Family	The prominins are an emerging family of proteins that among the multispan membrane proteins display a novel topology. Mouse prominin and human prominin (mouse)-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain [1]. The exact function of prominin is unknown although in humans defects in PROM1, the gene coding for prominin, cause retinal degeneration [2].	31.00	31.00	31.30	31.10	30.80	30.80	hmmbuild  -o /dev/null HMM SEED	807	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.42	0.70	-7.00	14	435	2009-01-15 18:05:59	2003-04-07 12:59:11	6	11	96	0	229	399	0	541.40	21	85.92	CHANGED	luhststhssupst.....t.htas.hhssppapsps....hsstshsslashs+phls...sVpspP.hPp-hlht...lhpsshshtsphp.p.........clltaphGhllsul....IulLallLMPllGl...CFCCC.RCptsCGGchppp-pppssCc.RthhslhLllholhlhhGllhuFlsNphhppsltpospthppslcDlpsalsssspplctlhsp.YpphpspltppLsssu..phlsstlpsphcupllssLpplhp..............slptscctLpslssphpcL+ptuspLpssLpuhRpplpssLsp..Cpsp........Csslh.shs.ltls....hcasplPslsp.lpslpplscsshsshlpcGhsphpplstplpppspssl....shpptLsshssslcshupplstp.ltsshsphhpssppphcshts.lccYspYRahsulllsslllLllhh.h.hGLLsGlhG.c+pssPsccsCsussGGpFLMhuVuh.FLhshhlhllslhhFllGuNsppllCcsh...pspplh.p.hlDoPh.Lst....htluthL.........phshslpl.....uplhcsCcpNpslassL+Lpshaslschhslpp...hopc.lppphpsl+l...slssl....plLsspu+csLpshtsoslschsassalpplp+slopssLsshApcLctlAsshssss......................l+ssLppcApsl+slppshlsshpshlscLppslpsL-pp....ssphstslsplLsplptupthlsspspphltptocphhsphlshhppYlsaVhpplspclupCpPlushhDsuh.shhCshllD......PhNuFW....huluhCthhhlPslIhuVKLuphY++hc..ss.ss	...................................................................................................h.....................................................................................................................................h.h...hhhh....hh.h....h.hhh.h.hhh.hPhhuh...hhshC..R........h.h......t.......t.......ts......s.p.........p.......pt.....+.hh....h...L.h.h.h..hh.h......hu.h.h.h.ahs..sp.hpt.t..ht...............h.psh.shp.hhpp...............s..ph.p.hlh...ht...p...ph..tlptht.....l..h..l.t....t...t..h...h..tth.t...................................sh.......h..hp.....ht...t.ht.t.lp..p.pl...htt..C.......................C......t...h..t......t.....s.............................p.t....h.........p.........thp....h...t........p.h...t...tt..t.hpth...ht.pht......h................h....t.htp.........t.h..t......p.h......h.....h...hh.t...............t........t...............h....p....ph....t....h.hh.shhh..hlhhlh.hh.h.huLhhG.hu..................ttsuu.hhhh..............uhhh.Fhh..hhhhlshhhhhhGssh.phhCtsh.........tptphh.p....hh...Dp.h.h................h..................................t....lph.....tphhptCpp..s.tshathhp.hpp...hslp...phh.p..hp....h..t..h..t..hpth..ph......shp...h........hlt.t.t..p..L.th..ts..htthp...hh.t.htt..s.........h....s...l..thttpl.pt..st...................................ht....th...t.s.thp..th.......p.h.............h......t......th..plt.lpt....................th..tht.h..lttht.hp..l.t...p.ht.hh..t.sp...thhtt..t.hppYhphh...tht.phutCtPhsthh.pps.....h..hCphhhs......sh...NhhW.....hslhh..shhhh.lP.lhhshph.phap..........s...................................................................................................	0	60	78	167
+5307	PF05479	PsaN		Photosystem I reaction centre subunit N (PSAN or PSI-N)	Moxon SJ	anon	Pfam-B_18582 (release 8.0)	Family	This family contains several Photosystem I reaction centre subunit N (PSI-N) proteins. The protein has no known function although it is localised in the thylakoid lumen [1]. PSI-N is a small extrinsic subunit at the lumen side and is very likely involved in the docking of plastocyanin [2].	19.60	19.60	20.00	20.80	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.67	0.71	-4.19	3	69	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	37	4	31	62	1	113.70	42	77.64	CHANGED	Vusup+A.sAlsQuA+PARAssVsVcuSssRRSALLGLAAlLuuTAAlAuSANAGVlDEYLEKSKsNKELNDKKRLATSGANFARAaTVQFGSCKFPENFTGCQDLAKQKKVPFIoEDLcIECEGKDKaKCGSNVFWKW	.................................................t...............t......t..s....t...s.p.RtuhlhLuus.lhssA..u....s..u...s..ApAull--YLcKSKANKELNDKKRLATohANhARuaTVpFGoCpFP.NFhGCp-LAhpptV.als-DhtlECcG.+.pth..CuSp...........................	1	6	17	24
+5308	PF05480	Staph_haemo		Staphylococcus haemolytic protein	Moxon SJ	anon	Pfam-B_18620 (release 8.0)	Family	This family consists of several different short Staphylococcal proteins, it contains SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic activity (SLUSH), phenotypically similar to the delta-hemolysin of S. aureus [1]. Gonococcal growth inhibitor from Staphylococcus  act on the cytoplasmic membrane of the gonococcal cell causing cytoplasmic leakage and, eventually, death [2].	25.00	25.00	32.10	31.90	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-7.91	0.72	-4.27	16	511	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	209	0	20	79	0	43.20	59	96.71	CHANGED	MstLs-AIsssVpAGlspDWuplGTSIlsIVtsGVshlu+l...FG	..MpGLh-AItsTVpAA...spDusKLGTSIVsIVtNGVGlLGKL...FG.....	0	2	2	20
+5309	PF05481	Myco_19_kDa		Mycobacterium 19 kDa lipoprotein antigen	Moxon SJ	anon	Pfam-B_19467 (release 8.0)	Family	Most of the antigens of Mycobacterium leprae and M. tuberculosis that have been identified are members of stress protein families, which are highly conserved throughout many diverse species. Of the M. leprae and M. tuberculosis antigens identified by monoclonal antibodies, all except the 18-kDa M. leprae antigen and the 19-kDa M. tuberculosis antigen are strongly cross-reactive between these two species and are coded within very similar genes [1,2].	26.90	26.90	26.90	27.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.10	0.71	-4.41	3	187	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	93	0	41	162	0	147.20	38	96.88	CHANGED	M+RpLpsAVAGssILsAGlSGCSSGNKS.TPSSScTToSouTTAS...PGAAAGs.KVlIDGKDQNVSGSVVCTTAuGsVNIAIGGAATGIAAVLoDGNPPpVKSVGLGNVNGVTLGYTSGTGQGNASATKNGNoYKITGTATGVDMANPhQPVNKSFEIEVTCs	.....................................................h.sGC..us..t.....t....s...stts.sss.ssu...........ss.s.s..uG.....s...pV..slDGpsps..s..ss.sVs..Csssu..........G..p..hsI...u.I...G..s.....s..s....s...G....l.uAVlo.s.G.ssP.pV.cSVu..L....GsV..sG......h..oLua..sp..GsG..t..G.sAsss+DGspYpIoGTAsGs.DhuNPhp..slsKsF-IcVTC...............	0	2	19	33
+5310	PF05482	Serendipity_A		Serendipity locus alpha protein (SRY-A)	Moxon SJ	anon	Pfam-B_19519 (release 8.0)	Family	The Drosophila serendipity alpha (sry alpha) gene is specifically transcribed at the blastoderm stage, from nuclear cycle 11 to the onset of gastrulation, in all somatic nuclei [1]. SRY-A is required for the cellularisation of the embryo and is involved in the localisation of the actin filaments just prior to and during plasma membrane invagination [2].	19.00	19.00	60.30	59.50	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-13.02	0.70	-6.07	4	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	32	0	26	68	0	427.70	41	87.27	CHANGED	MEpLLtQLslCsELIApG.oCssGpIuWLNEFCATFLDFAS-LKA+LPElAP+..h.EGGsNI-VETIFLCLTQVVTCITQLERTINIEus.uttsp..MTRhHFLDRIDWClRRlhsSLoQLc.pttssssssLEDHoFVELMDLALDHLEsaMEtLusposs..LhI.EEs-op-hhQLuSIVNHIVRHALAFANVALEuDKKALStLCETLLuECuTFhEsuuEhNPGHRKLEALSLERALYuLETaLNEALLHLIFsSll-LENssIp+LRcALQpp.-..Suhs-pLlSDFDTNMDRIQQIGVLAIAFSQDlKTKTIVRSCLASLESLDACIVPALQ..poo.usHHADILEHHFNpElLIFRNlIHEIIDSRSLINNYLDMLAES..IHlAsK..P+saL.LIVQMGuVlh-HFRLPVNYStL..S-.DGKRlHpDhlLIL+EC.AVVslus.VDPKRIVKRLKILYSVLAKLRDlID+s.h.+-.......s.s.......Sc+phTsATRThlR..+ShuKRQRSFV+QptsssVssPps..sSlusSlSp-uDLISFQLTEILRIs	...........................................................................................................................................................LNthCu.hhphsp.hp..h....................Ehhh.LCloQlhhClp.lEpshphpt....................o+.aFlDRlpaClp+lhh.h...........t.t.s...t....htc.sFlplhDhuLDhlt.h.ph..ppspt..............p.h.....s.hpLtshlspllppALAFANVAl.ppDK+ALouLCppllpECs..sFp..cp..s......t........c.sss.u....p....p....KLcAhoL..............EcALYtLEsalN-ALL+L...lFsshhDh-...pt...ulcKL+....sh...Lp........p.s.......sstsp..clIusFDsNhDRlpQIGlhAIAFupclKtKThlRSCLASlESLDssllPuLQ..........u..suushHu-lLppHFppEhhhF+sslpEIIDSpuLls.sh........L-hLs-p..I....cst....pp.....+phL......llQhu...tllh.cHFpL.lNh..psL....sc....p....G.pch....a......p...chlhlLpEC.p.A...l.....l...........h....ss....l-...Pp..............RIlKRhKILholLtKL+ssls..tt................................................................................................................................................................................................................	0	6	8	20
+5311	PF05483	SCP-1		Synaptonemal complex protein 1 (SCP-1)	Moxon SJ	anon	Pfam-B_19633 (release 8.0)	Family	Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase [1].	19.50	19.50	19.50	20.10	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	786	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.95	0.70	-13.70	0.70	-6.76	2	74	2009-09-11 15:44:23	2003-04-07 12:59:11	7	4	40	0	35	67	0	520.20	42	79.88	CHANGED	hGGDSsaFKohNKCTEsDFthPhshosLSKNtENIDoDPAhQKlshLPhLEQVuNS.sCHYQEGlpDSDhENSEshSRlYSKLYKEAEKIKKWKVShEuEL+QKEsKLQENRKIIEAQRKAIQELQFtNEKVSLKLEEtIQENKDLIKENNATRHhCNLLKETCARSAEKTpKYEYEREETRQVYhDLNNNIEKMIhAFEELRVQAENuRLEMHFKLKEDaEKIQHLEpEYpKElNsKEpQVSLLLIQ.TEKENKMKDLTFLLEESRDKsNQLEEKTKLQsENLKp..EKpcHLTpELEDIKhShQRShSTQKsLEEDLQIATKTIhQLTEEKEsQMEE.NKA+ssHShVVTEhcsTsCoLEELLRTEQQRLEpNEDQLKllTMELQKKSSELEEMTKhpNNKEVELEELKplLuEcppLL.EpKQhEKlAEELpGpEQELhhLLQsREKElHDLElQlTshpTSEpaY.KpVc-hKTELEpEKLKNhELTupsshL.LENKcLsQEsSDMsLELKppQEDI.NsKKQEERMLKQIEsLpEpEhpLRsELE.VRcEhhQptDEVKCKLDKSEEN.....................CNNL+KQlENKsK.IEELpQENKALKKKuoAEsKQLNsYEIKVNKLELELtSsKQKFtEhhssYQKEIE.KKISEEpLLtEVEKAKshsDEAVKLQKEIDhRCQHKIAEMVALMEKHKHQYDKIlEERDSELGLYKs+EQEQSSh+suLEhELSNl+sELlSlKKQLElE+EEKEKLKhE.pENTAhLp-KK	..............................................................................................................p....s...plaSKLacEsEKIKpWKlph-u-lpQKEp+LQEN++hIEsQRKAIQELQ...FtNEplSlKLE-tIpENcDLhpcNNATRpLCNlLK-Tht+osEKhphaE.EREET+plah-.spNlp+MlhAFEpLRhQAEssp.EMp...KlKEph.phpcLcpchctEhp.KEcplulL.hp.p-KEschcclhh.LpEopcphspLpEtpp.ppE.LKpu.tcpctLhpcLp.hp.sh...pct.tsp.cslp....pLp.s...hcph.plhtpK...-sphEp.pph+..ps..ltphphshtpLpp.Lp.E.p.Rhpp....cp.p.p.h..-Lpp+sttltphhc.pp.pchp.lp..Lpp.Ltptp........pp....hpth.tphp.tpppl..h...l.....hptphtchp.....hts.ht.tpp....ph.phpt.phpp...t.h+p.pL..php.l..p.ptth..ph..h..p.p..................................................h......p.ph.......ph.....t...........................h......hc+......t....pp..tp..ct..hpppNchLKKp.stE.pp.p.h.phplspLp.Ehpshpp.htE.hpph.c-lc..pKph.t..tpL.tElcKh+hhssEulK.pcEh-h+CQpKIs-MlALMEKHKtpYD+hlEE+DuELt.hp.+EpEt.u.hctuLE.ELsphcs-l.pl+.pLc.ph.tc.K.........................................................................	0	6	8	17
+5312	PF05484	LRV_FeS		LRV protein FeS4 cluster	Bateman A	anon	Bateman A	Family	This Iron sulphur cluster is found at the N-terminus of some proteins containing Pfam:PF01816 repeats.	20.90	20.90	21.80	35.20	20.10	20.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.03	0.72	-4.39	4	74	2012-10-11 20:01:00	2003-04-07 12:59:11	6	6	68	1	40	71	0	55.80	44	21.33	CHANGED	usEsl...s.hs-CRsCpFc.sLL.oGRCs.GcuCVss+puRpIDRFFRpNPpLAscY	........s..tslDWpGp.lcCssCsHc...slh.sp.G+..Cc.s+ACVpDRYARRIDRFFphNPsLAspY...	0	12	28	32
+5313	PF05485	THAP		THAP domain	Bateman A	anon	[1]	Domain	The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.33	0.72	-3.81	139	1658	2009-01-15 18:05:59	2003-04-07 12:59:11	7	123	120	6	1163	1895	1	83.30	23	22.91	CHANGED	ppCss......sC...........tpppppps.lphacFPp...cpp..hht.pWhpshptp................sppt.......tlCspHFpspsh.................ppppLpssA......VP.......olh..ttspt	.........................Css..sC.......................tp..p.p..pp.s...lpha........p.F.....Pp................c..p.......hhp..pWhpshpppsh...............t..pppt..........hlCupHFp..sp.sh..........................tp.ptLp.sA.......lPolh.....s............................................	0	346	432	912
+5314	PF05486	SRP9-21	SRP9; 	Signal recognition particle 9 kDa protein (SRP9)	Moxon SJ	anon	Pfam-B_7787 (release 8.0)	Family	This family consists of several eukaryotic SRP9 proteins. SRP9 together with the Alu-homologous region of 7SL RNA and SRP14 comprise the "Alu domain" of SRP, which mediates pausing of synthesis of ribosome associated nascent polypeptides that have been engaged by the targeting domain of SRP [1]. This family also contains the homologous fungal SRP21 [2].	20.90	20.90	21.90	23.20	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.54	0.72	-4.24	33	286	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	247	3	199	271	1	80.00	33	58.17	CHANGED	alpshppFlctSppLhpupPspTRhohKYpt........................................sssslslKsh-spsu.ClKY+TsKut-luRLlshhG.husshs	........hpoh--FhctuppLatusPp.psRhshKYpa.............................................................scupLslKspDsts..CLpY+Tspup-lp+l..p.h.hupLhphh.s.............................	0	59	99	155
+5316	PF05488	PAAR_motif		PAAR motif	Yeats C	anon	Yeats C	Motif	This motif is found usually in pairs in a family of bacterial membrane proteins. It is also found as a triplet of tandem repeats comprising the entire length in a another family of hypothetical proteins.	23.00	23.00	23.00	23.10	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.68	0.72	-3.99	88	2205	2009-01-15 18:05:59	2003-04-07 12:59:11	8	110	944	0	577	1932	242	74.40	27	19.69	CHANGED	lhh.GDp.TspGGpV................l.su..usshhhsGpslAhhG..........D..hssCPts.......usssIlp..G..s.s..shhhsGpslAhpGcpssC...........Gs.....pLluu	.......................................................................................................................p.sG..l....................h..sG..ssshhht..Gh..ss.AphG.........................................................................D......hs.sCspp................ssshIsp.....G.s..s....slh...l...s.GpPsA.phGc...ps.s.C...................Gu........hlh...................................	0	76	220	365
+5317	PF05489	Phage_tail_X	Tail_X; 	Phage Tail Protein X	Yeats C	anon	Yeats C	Domain	This domain is found in a family of phage tail proteins. Visual analysis suggests that it is related to Pfam:PF01476 (personal obs: C Yeats). The functional annotation of family members further confirms this hypothesis.	20.60	20.60	20.60	20.60	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.81	0.72	-4.49	32	981	2012-10-01 23:00:54	2003-04-07 12:59:11	7	7	753	0	144	576	23	58.70	40	67.46	CHANGED	MKsaAl.QGDTLDAIClRYYGRT.EGVVEsVLAANPGLAELGsVLPHGTAVELP...DVQTAPVA	...............................pshuh.pGDTl..DuLCaRaY..Gc...o..pG.ss...E.pVL.p..A..NPG.....L.....Aph....s....h..LPtGhtVplP...-lptt.........................	1	29	67	110
+5319	PF05491	RuvB_C		Holliday junction DNA helicase ruvB C-terminus	Moxon SJ	anon	Pfam-B_844 (release 8.0)	Family	The RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein [1]. This family consists of the C-terminal region of the RuvB protein which is thought to be helicase DNA-binding domain. 	24.70	24.70	24.70	25.80	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.30	0.72	-4.35	126	4372	2009-01-15 18:05:59	2003-04-07 12:59:11	8	5	4328	12	944	2793	1004	75.80	54	22.41	CHANGED	VDphGLDphDR+hLpsllcpasGGP...VGl-TlAAuluE-psTlE-VhEPYLlQpGalpRTPRGRlsTptAYpHLshs	...VDptGLDhhD++lLpslI-pFsGGP...VGL-TLA...AulGE.EpcTIEDVhEPYLIQpGFlpRTPRGR.lATspAYpHhGh.s.....	0	325	633	805
+5321	PF05493	ATP_synt_H		ATP synthase subunit H 	Finn RD	anon	Pfam-B_3341 (release 8.0)	Family	ATP synthase subunit H is an extremely hydrophobic  of approximately 9 kDa [1].  This subunit may be required for assembly of vacuolar  ATPase [1]. 	25.00	25.00	28.40	28.40	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.34	0.72	-3.90	34	346	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	230	0	214	332	0	64.60	36	75.96	CHANGED	hslllsolhashhuhhu.hhsPK............u.spsllpshllLou.ssCaLhWhlsaLAQhsPLluPphsspp	...................h.slllholha...shl...G..hhss....hhsPK........................GsspsllpshLl.lTu.lCCaLhWhlsaLAQhNPLluPplpp.........................	0	74	113	167
+5322	PF05494	Tol_Tol_Ttg2		Toluene tolerance, Ttg2 	Finn RD	anon	Pfam-B_3575 (release 8.0)	Family	Toluene tolerance is mediated by increased cell membrane rigidity  resulting from changes in fatty acid and phospholipid compositions,  exclusion of toluene from the cell membrane, and removal of intracellular  toluene by degradation [1].  Many proteins are involved in these processes.  This family is a transporter which shows similarity  to ABC transporters [2].	21.50	21.50	21.80	25.20	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.92	0.71	-4.70	160	1882	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	1658	1	420	1153	1732	167.90	28	80.72	CHANGED	lppssscllshlpsspsth.......pth.....hphlcphltshhDhpthuphslG.p.......a.............+.psospQ+.....ppFhptFcphLhpoYu.stlspas..s........pp..lpht..thpss.....ppshVpoplhpsss...pslplsaplpp.....tss.p..W+laDlhlp...G.lSllpshRspFsshlppp.G.l-sLlpp.......Lppcs	............................ppsspcshspL+sppsph.ptss...shlpslVcpplhPalshchhutllLGph...a.............+.pAoPtQp........ptahpuFcphLhpsYu.psLs..Yp..s........Qs......hplt....hs........stshsslcssllssss...sslpl-aphpc......psG.s..WpsYDhhsE...G..lShlsohp.spaushlcpp.G..lDuLhtpLcp..h......................	0	114	234	328
+5323	PF05495	zf-CHY		CHY zinc finger	Wood V, Bateman A, Mistry J	anon	Pfam-B_5537 (release 7.8)	Domain	This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues. We have named this domain after the N-terminal motif CXHY. This domain can be found in isolation in some proteins, but is also often associated with Pfam:PF00097.  One of the proteins in this family (Swiss:P36078) is a mitochondrial intermembrane space protein called Hot13. This protein is involved in the assembly of small TIM complexes [1].	23.30	23.30	23.30	23.60	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.78	0.72	-3.82	76	971	2009-01-15 18:05:59	2003-04-07 12:59:11	7	24	596	2	499	817	15	75.40	32	23.00	CHANGED	CpHYcps...stl+ssCC..scaYsCt................pCHc-tp.........sHphpRhs.p........tllCshCppt..shsph.............tss.....phhCshCp........ha.	........................CpHYcpp...stl+ssCC..s+..a......Y.sCh................pCH.sc..t.p......................................cH.sh...p+hshp...................tllCuhCppp.shsph...........................tps..............hCshCphh.................................................................................................	0	165	308	434
+5324	PF05496	RuvB_N		Holliday junction DNA helicase ruvB N-terminus	Moxon SJ	anon	Pfam-B_844 (release 8.0)	Family	The RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein [1]. This family contains the N-terminal region of the protein. 	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.40	0.70	-5.32	110	5721	2012-10-05 12:31:08	2003-04-07 12:59:11	7	23	4390	12	1243	22353	7697	210.90	46	58.50	CHANGED	Rl.lssp....tttp.....-....pshEtuLRPppLs-alGQcclKcpLplaIpAA+pRsEuLDHVLLaGPPGLGKTTLApIIAsEhGVsl+hTSGPslE+sGDLAAlLTsLpssDVLFIDEIHRLspsVEElLYPAMEDaplDIlIGcGPuARol+l-LP.FTLVGATTRuGhLouPLRDRFGlhtRL-FYss--LppIlpRoAclLslslss-GAtEIA+RSRGTPRIANRLLRRVRDaApVcuc	.............................................................................h..............-..p..h-..ps.L..R...P........p....p....L....c.....-....a.....l.....G.Q...p....c.l...+....p........p......l.....c........l....a........I.............c............A............A...........+........h............R................s............-................s...............L............D..................H..............l...........L..l....a.G.P.PGLGK...TTL..A.....p........I....I...A...s...........E.......h..........G........l........s............l..........+............p........T..........S...............G..........P...........s.......l............-...............+..............s..............G..............D..........L................A..............A...............l............L............o..........s..........L..........p......................t..............D.............V...........L........F...........I.D...........E.....I.....H......R.....L...s...................s...............l......E..........E...........l...........L....Y..P...A........M......E....D.......a.............p....l.......D......I.....h......I.....G......p.......G.......s.......u...A.....+...o...l........+......l....-........L............s...................F......T..L..l.G..A.....T....T.....R......u..G............L...o..sP..L....R..D..RFG..l..h...+h-.a..Y..p.....t..-....L...ptI..l.t.....R...o...A.t..h..h...t...h...t........h...pt...p.u.A....hE.lA....pR.uR..G.TP..R.I.AN....RLL+RVRDaApVpts.......................................................................................................................................................................	0	440	849	1068
+5325	PF05497	Destabilase		Destabilase	Finn RD	anon	Pfam-B_4147 (release 8.0)	Family	Destabilase is an endo-epsilon(gamma-Glu)-Lys isopeptidase, which cleaves  isopeptide bonds formed by transglutaminase (Factor XIIIa) between  glutamine gamma-carboxamide and the epsilon-amino group of lysine [1].	26.20	26.20	26.40	28.10	25.30	26.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.35	0.71	-4.01	28	193	2009-09-11 15:14:13	2003-04-07 12:59:11	7	4	73	4	107	201	1	109.90	35	68.13	CHANGED	lossCLpCICcspS.GC.tsls.CchD.h.p.uCGhFpIppuYWhDsG+...PGss........apsCusDhsCusssVpsYMp+Yt....psCsss....CcsaARlHsGGPpGCc.....ps.shsYhpplppphs	......................sptCLtClCpstS.GCptshh.Cp.s.......sCGhFpIohsYWhDuGc......sscs.....tt..uapsCss..D.pCAspsVpsYMp+as..pcCssct..sCpDautlHphGshGCp.....s.p..h.s..h..tY.phhppCh.p...................	0	43	56	93
+5326	PF05498	RALF		Rapid ALkalinization Factor (RALF) 	Finn RD	anon	Pfam-B_4453 (release 8.0)	Family	RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root  growth and development [1].	21.30	21.30	21.30	22.00	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.46	0.72	-3.15	34	313	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	35	0	202	290	0	64.10	36	55.35	CHANGED	tttt.shhsu.sspRhhttp......pYIS.YsALc+splPCs.pcGsoYY..sC.cssspANPYsRGCSsITRC+c	.......................s.........s..tpRhlttt.........pYIS.YuA.Lp+s.plPCs..ppGs.SYY...NC.ps.s..........stANPYsR..GCotITRCRt..............	0	40	107	152
+5327	PF05499	DMAP1		DNA methyltransferase 1-associated protein 1 (DMAP1)	Moxon SJ	anon	Pfam-B_38340 (release 8.0)	Family	DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and histone deacetylases (HDACs). The chief enzyme that maintains mammalian DNA methylation, DNMT1, can also establish a repressive transcription complex. The non-catalytic amino terminus of DNMT1 binds to HDAC2 and DMAP1 (for DNMT1 associated protein), and can mediate transcriptional repression. DMAP1 has intrinsic transcription repressive activity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targeted to replication foci through interaction with the far N terminus of DNMT1 throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase, providing a platform for how histones may become deacetylated in heterochromatin following replication [1].	25.00	25.00	25.00	25.30	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.72	6	129	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	103	0	88	119	0	152.70	44	34.72	CHANGED	EEEhLlsELRKIEsRKKEREKKsQDLQKLIotAD..........oTuptR.KpEKKhhKK..Klspp.ts.+pspclsVsE..ouGIKFsDhKuuGVoLRSQ+MKLPusVGQKKlKAlEQhLpEhtVDhsPsPTE-IsphFNELRSDhVLLhELKpAhusCEaEhpoL+H+aEALs.GKslshP	...........................................EEphLltEL+KIEtRKKERE++sQDLQKLIotAD.......................sssp.R....+.tE++h.KK.......Kls.p.p.........+p.s....pt.ssss-.............suGIKFsD.h.+uuGVpLRSQ+M.....K.....LPu...ulGQKKlKulEQhL.pE.luV.-.............LsP.sPTE-lsp.FNELRSDlVLLhEL+pAhusCEaElp.LRHpaEAhs.utsh...t.................	0	29	39	66
+5329	PF05501	DUF755		Domain of unknown function (DUF755) 	Finn RD	anon	Pfam-B_4891 (release 8.0)	Family	This family is predominated by ORFs from Circoviridae. The function of this family remains to be determined.	29.10	29.10	30.00	39.50	29.00	29.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.77	0.71	-4.06	21	74	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	29	0	0	75	0	125.50	27	50.26	CHANGED	ps.cpshhsPIsSpKQYKLtsQppps.ptssTsGTo-sshLpppLLKECpKTupLhpL.ppl..............ppccpppsspspp+++K+p+psStppuKKhpsK++.......tpssSSSSSSssuoSSSppSS	.........pph.tPlsShcpYK.hTppsps.pssSTsGTs-sssLtppLLKECppTppLh.phh.ppltpp.............ttpp....pp....ppps...s...ppppccpp.+p+phstp..pt++.ppp+++............pppsSSSSSSssssoosppo.s.....................	0	0	0	0
+5330	PF05502	Dynactin_p62		Dynactin p62 family	Finn RD	anon	Pfam-B_4912 (release 8.0)	Family	Dynactin is a multi-subunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein. p62 binds directly to the Arp1 subunit of dynactin [1,2].	22.90	22.90	23.20	22.90	22.10	22.80	hmmbuild  -o /dev/null HMM SEED	483	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.84	0.70	-5.73	11	399	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	215	0	284	414	0	252.30	19	75.82	CHANGED	P.EpLlaCEDCHQIKCPRCloEEIssaYCPsCLFEoPSStlR.EtN....RCARNCFsCPhCsuPLuVssl-s...........ssuussppGPasLoCuYChWoohDlGlpF-KPssIphQLuK.....................hp....t....su+tht......-h+pshSoauoh-s............tpts...pp.sssLsh-s+FssLKuFYKsQlusssoussD.hth.chus....uFuuPs..uLsRhMslYsuuupl.shhs.spKKs+s+P.s.hR-ALssoEGLpl..ts.sEsshIpphss.......puasulASl-QhhhQ.sPss.........RFsE-LLPlPVLLRTKRSKRCcsC+HILlKPEhKspSsRFRI+LlAlsYIP..sl+...............................sL..ss...............s...s.sssslcsLpPh+shQllLTlKNhhF-PV+VTLuTPusT.PGRluoK...VTlLCPpF-IsuNpDsWpEALp............................hssus.c.uS+uushshst-+ssEuGKVW-+GRNWTolVLEVVPuoLs.......sttssp.phppccDs	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	99	143	231
+5331	PF05503	Pox_G7		Poxvirus G7-like 	Finn RD	anon	Pfam-B_4957 (release 8.0)	Family	\N	20.00	20.00	20.10	100.60	19.80	17.00	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.08	0.70	-5.85	11	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	42	0	0	50	0	356.90	62	98.52	CHANGED	MtEt..KQS.....pIFsIloKullpSls+sh..shsssYIpuKAKpLhYssssoh+-ulINuIYspsEssIslsshscLhclLspL+ppusYVsNssEFWRLYNSLhRFTHspSFFssChPTIlsTLATLlTLlLuNcLLaAA-MVEulEsYLFs.upKs.uQELADLL-MKYGLINLVQYKIhPlllGppt......p..hhuu..uuss.ssassEl-+LhELPVKoshlsplYcFLsc+GlsToNNaAEYlAGLKIEElsp...........................tss.t...t.s..sht.ppptshtthc............lLcpApKYSKGHVLDGuVoSPlTtpt.lsspIP..............hosoDlcKFsILEYLYlMRVhANsIK+Ks..tpspsp.GIsLsINS.PFKoITlPus	.........t.tEQ..RpS.....TIFDIVSKsIVpSVLRDI..SINoEYIESKAKQLCYC.suSKKESVINGIYNCCESNIcIhD+EpLLKILDNLRsHSsHVCNuoDFWRLYNSL+RFTHTTuFFNTC+PTIlATLsTLITLILSNKLLYAAEMVEYlENpLsS.SNKSMSQELA-LLEMKYALINLVQYRILPMIIGEs..........IIlAGhsGKpPhS-YSuEVERLMELPVKTDIVsssYDFLuRKGIcTSNNlAEYIAGLKIEElpKspphhs................shushANSshlKs+K...SIhPA..NIND+pIMEso+............hLDsuEKYSKGacsDGAVTSPLTuNsT.IooaIP..............ISASDMQKFTILEYLYIMRVMANNVKKKN...EuKNsGGVVhpINS.PFKlIslPp.s....	0	0	0	0
+5332	PF05504	Spore_GerAC		Spore germination B3/ GerAC like, C-terminal 	Finn RD	anon	Pfam-B_5052 (release 8.0)	Family	The GerAC protein of the Bacillus subtilis spore is required for the  germination response to L-alanine. Members of this family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the  germination apparatus that respond directly to this germinant,  mediating the spore's response [1].	21.30	21.30	21.40	21.40	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-10.82	0.71	-4.48	137	1584	2009-09-10 14:51:44	2003-04-07 12:59:11	6	5	321	1	349	1395	6	166.40	21	45.64	CHANGED	lsGsAlF.+s..cKhlu.hLstp-spshphlpschps.Ghlslphsppt................................................hlsh.plhpsc.sclcsph.cssch.p...hpl..plphcupltEhp.sths..h.s....tchlpplEcthpcplccphpphl.cchQ.chpsDshGhGchh+p..phscha.p.h.ppcW..p...ch.aspspl.clpVclpIppsGhhp	....................................sGhAlh..+s...sKhhu.hLstc-shshphlp..sc.hp......t..uhhp.hp.h.spst................................................hlsh..ph.h.psc...sclcsph..pss..p..phpl...clphcupltEht..pshs....h.p.....cphcplcctlpcplccchpphl.c.phQ.chpsDshGhGchh+p..pp.chW.p.h...pcpW....p.....ph..as...cs.pl.plplclpIppsGh..p..................................	4	178	289	304
+5333	PF05505	Ebola_NP		Ebola nucleoprotein	Moxon SJ	anon	Pfam-B_8475 (release 8.0)	Family	This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus [1].	25.00	25.00	186.20	186.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.16	0.70	-6.46	4	104	2012-10-01 19:59:50	2003-04-07 12:59:11	7	1	21	0	0	58	0	391.30	83	98.86	CHANGED	hDYHKILTAGLoVQQGIVRQ+lIsVY.VNsLEuICQhIIQAFEAGlDFQ-sADSFLLhLCLHHAYQGDa+LFLcSsAVpYLEGHGF+FEV+K+-sVpRL-ELLPssouGKNl+RTLAAhPEEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYPTuWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDuVISNSVAQARFSGLLIVKTVLDHILQKTDpGVRLHPLARTAKVKNEVsSFKAALSSLAKHGEYAPFARLLNLSGVNNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAATEAEKQLQQYAEoRELDsLGLDDQE+KILMsFHQKKNEISFQQTNAMVTLRKERLAKLTEAIT.........tASps+lus+asDDs-IPFPGPIpssspss..-DsPpDSRDTsIPssVlDP.Ds-.spYsuYp-sthssssDLsLFsLD-D-.DDo+shP........ptsp..Gpps.phpsh.+PP...PGspps.p.+tStshsssspppt..............PptspusRh..LoPlpEEs-s.DpsDs-spSLssLES-D-.....EQs.Dhot.....VAPPAPVY+s.tctctlspsppNs.spTsphtsp-uDh......sSpsppshEETYhHlL+oQGPF-AlNYYHhMpDEPlhFSTccGKEYhYPDSLEEsYPPWLoEKEtl-cENRalslcsQQFhWPVMSh+-KFhAl	..........................................................................................................................................................................................................................VuQsRFSGLLIVKTVLEFILQKTDSGVsLHPLVRTSKVKNEVASFKQALSNLARHGEYAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAp-AEhpLQ+htEppElpulu.DDpERKILcpFH.p................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+5334	PF05506	DUF756		Domain of unknown function (DUF756)	Yeats C	anon	Yeats C	Domain	This domain is found, normally as a tandem repeat, at the C-terminus of bacterial phospholipase C proteins.	24.40	24.40	24.80	24.40	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.08	0.72	-3.50	86	1055	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	296	0	344	1014	25	89.40	29	23.80	CHANGED	su+AlPYp.clpsphcsuss.plpLph..sN...s......G..psuu.......sFpVhs....pt.t.....h.s........stP.............................cpYsVpu...........Gpp.lpspW..sh.ssssGhYDLtVhG....PsG..FhR+FsGc	......................................................................ttshshp.cl...ps.....p.hc.....ss....s.....u....slpLph...sN......s.........G......pt..us.......sap.Vhs.........tt.h.....t.t.................stP..................................................................t.p.a.sVpu...........Gpp...lps..p.W...sh...sss...suhYD..l..s..Vpu.....ssG....FhR+FsGc...............	0	78	159	274
+5335	PF05507	MAGP		Microfibril-associated glycoprotein (MAGP)	Moxon SJ	anon	Pfam-B_8462 (release 8.0)	Family	This family consists of several mammalian microfibril-associated glycoprotein (MAGP) 1 and 2 proteins. MAGP1 and 2 are components of elastic fibres. MAGP-1 has been proposed to bind a C-terminal region of tropoelastin, the soluble precursor of elastin. MAGP-2 was found to interact with fibrillin-1 and -2, as well as fibulin-1, another component of elastic fibres this suggests that MAGP-2 may be important in the assembly of microfibrils [1]. 	28.00	28.00	29.60	40.60	22.50	27.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.86	0.71	-4.36	4	107	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	40	0	49	96	0	120.30	53	77.79	CHANGED	hhhGsKsLLhLsAhllsSshhPLGVsuQRGDDVp.spsETFTEDPNLVN....DPuTDET.........VLADItPSTDDLAu......s-KNsTsECRDEKFsCTRLYSVHRPlKQClHQlCFTSLRRMYllNpEICSRLVCKEHEAMKDE	.......................................................hs.hhLLhh..h.lsp.t.h.lts.s.hsDpl...p.ps.h-sP.sh.h.s...............sPtsspp...............tl.t-...l...h..Pusss..ss........sscsssh....-CR-EpasCTRLYSVH+PsKQClpp.lCFhSLRRhYllNKEICsRhVCtccEhh+s-...........	0	3	7	16
+5336	PF05508	Ran-binding		RanGTP-binding protein	Wood V	anon	Pfam-B_37054 (release 8.0)	Family	The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The S. cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was identified. The protein competes with yeast RanBP1 (Yrb1p) for binding to the GTP-bound form of yeast Ran (Gsp1p) and is, like Yrb1p, able to form trimeric complexes with RanGTP and some of the karyopherins [1].	25.00	25.00	39.90	25.40	22.10	24.00	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.79	0.70	-5.53	18	126	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	112	0	95	128	0	299.00	40	58.01	CHANGED	MDplLu+susQAVoF....AIRSGIolASsYAl+pso+aLcplsps-p......pclcpl+p+LcoKIcIlSsAIDLIcLhuAR..........GNTsLEuslsLscsL+t-IspFsp+lsphspt..............spsspspccslppl.cthKcLLsRI--AlPLlNLulTTSGsslsosL.....ssslSPuRLLQASsalsp..............................usspasts.p............slQlGPoFsLohYslFhs.s.+.t.........................-u.pplsWKEsht+upl+lhRh....................................scpscYuYpLcIhEDasDGRYH---..............tshphplslppIs+lFFosSGKLLplpsp....soPVLlLKhsps.ts	........MDthLs...+hspQAhsa....AIRSGIulsusYAlpphophlp...................p............lstppt......pclppLptcLps+IpIlSsAIDhIcLhAAR..........GNTsL.........ESsltLs+sL+.-Ipphsp+lsphsp..p............spsppppctplptl.ptl+pLLtRI--slPLlNLulTTSGssLoosL.....PsslSPuRLLQASsalot..................................................usppas.s.pp...........slQlGPoFsLolYhlFhshs.p...t................................................-u.ppssWKEsh++A+l+lhRhs...................................uptsca.....uYplhIhEDhDDGRhHs.-t............h..ssh+chlslppIsKlFausoGKlLpltsp....ssPVLlLKhDhp.h..............................................	0	18	46	79
+5337	PF05509	TraY		TraY domain	Moxon SJ, Bateman A	anon	Pfam-B_8963 (release 8.0)	Domain	This family consists of several enterobacterial TraY proteins. TraY is involved in bacterial conjugation where it is required for efficient nick formation in the F plasmid [1]. These proteins have a ribbon-helix-helix fold and are likely to be DNA-binding proteins.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.04	0.72	-4.19	28	257	2012-10-02 18:44:02	2003-04-07 12:59:11	6	3	175	0	28	195	6	48.00	45	68.00	CHANGED	lhlpLcpcsNchL.putc+SGRSKppEAtlRLpDHLpcFschhpsphpt	..........hpLD--TNphLltApsRSGRoKThEsthRLpDHLp+FPDFYstEh..p...................	0	4	9	15
+5338	PF05510	Sarcoglycan_2	sarcoglycan_2; 	Sarcoglycan alpha/epsilon	Moxon SJ	anon	Pfam-B_9181 (release 8.0)	Family	Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear [1]. This family contains alpha and epsilon members.	27.00	27.00	27.20	28.10	25.60	24.30	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.25	0.70	-6.16	5	222	2009-09-12 20:59:17	2003-04-07 12:59:11	8	3	82	0	95	170	0	320.00	44	91.77	CHANGED	stlhLLs..hhulLstspSs+ht......TlploVGcLFsHpLEschF....sasscssopp...loY+soLcGYPDLPsWLRYpQcssY+sGFLYGSPTscsAGp.lsIEITAaNRcoFET+RpcLhLsIscsps..LPYQAEFpI+NhNl-chLsospl-sF+stl+s.LWptsPc-LpVlNl-SALDRGGRVPLPPp.pKEGVaV+VGSsspFSopL+El...VpP..pl.uCoQcpsPVtosa-shhopF+lDWCsFpLV-Los.........pssp-ppshp.stG-GhLacDsaauPPs-clscRDYhs-FlloLAlPuhIsLlLhllLuhIMCFpREGhhc+cpc.................ssclQhsHHSuIp.......+SThcLRpMAcsp-lshPLoTLsSacshsu.............-R.PP.spcpsDsTsMPhhpssp	......................................................................h...........slh.t...tssp.........slhs.sGhlFVHsL-p.chF...........h.s.s.sp...........lTapssL.GaPDhPtWLRYhQRosapsGhLYGoPTs-shG+.plIElsAYNRcoF-TsRppLllp..Ihs.s...E...t....LPYQAEFhl+shsVEEhLs..S..pshscF.LsAlps.lWp....PtcLphlNITS..ALDRGGRVP....LPIp...shKEGVYlhVGusssFSsCL+.l.....sPtpph..pCs..p..t.tsllss.cph..hspFhlDWCplsL...V-hsh.........................ss.p.sh.................Gp.GlL...cs..s.....apPPp-s..s..Rs...ahsD..h..llTl.hlP...hlALlLhhlLualMCsRREGh..t.p..t....................................ss.tIQhlHHssIp.......tsTcELRpMu..tsRclsh.PLSTLPhFpshoG.............EhhPP.....ph-ssphPhh.sp.....................................................	0	20	27	57
+5339	PF05511	ATP-synt_F6		Mitochondrial ATP synthase coupling factor 6	Moxon SJ	anon	Pfam-B_9347 (release 8.0)	Family	Coupling factor 6 (F6) is a component of mitochondrial ATP synthase which is required for the interactions of the catalytic and proton-translocating segments [1]. 	27.90	27.90	28.50	31.60	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.32	0.72	-4.10	17	159	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	102	5	80	157	0	92.10	42	71.49	CHANGED	Mhh.....phsthhtssholphRRNlGlo.Ashhs..KthDPIQpLFlDKlREY..KppsoGG.hVDAuPEhp+-LpcElpKLpphYGGu...DMspFPpFKFp-	...............................................h.phhshth.+RN.luho.Ashhs...Kt....hDPIQ+LFlDKIREYpsKppu.uG.G...VDuuP-ap+-LpcELpKLpphYGsu.....DhspFPpFKFp-..........	0	25	33	56
+5340	PF05512	AWPM-19		AWPM-19-like family	Finn RD	anon	Pfam-B_6960 (release 8.0)	Family	Members of this family are 19 kDa membrane proteins. The levels of the plant protein AWPM-19 increase dramatically when there is an increase level of abscisic acid.  The increase presence of this protein leads to greater tolerance of freezing [1].	19.90	19.90	20.70	20.50	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.77	0.71	-4.19	12	134	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	29	0	80	129	1	126.30	45	74.10	CHANGED	hLNLsMYlllluluuWulN+tI.s.Ghp.tsuhu....h.Phah..GNsATGFFl.hFullAGVVGsASsLsGhpH....lRsWpspSLsuAAouuhlAWuLThLAMGLACKEIp.......lGt.RshRL......RshEAFhIILohTQLLYlhulHuGh	.............................hLNhsMYlIlhuluuWulN+tI.s....uh..tsshs.....................GNsATsaFl.hFuLlAGVVGhAS.slsGhpH....lRs.WpscSLsuAuusuhlAWsLTlLAhGlACKEIp.......lut..Rst+L..................+slEAFhIILuhTQLhYllhlHuG.h...........	1	15	51	67
+5341	PF05513	TraA		TraA	Moxon SJ	anon	Pfam-B_9521 (release 8.0)	Family	Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce an inhibitor of cPD1, termed iPD1, which functions as a TraA antagonist and blocks self-induction in donor cells. TraA transduces the signal of cPD1 to the mating response [1].	21.30	21.30	21.30	21.40	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.58	0.71	-3.94	2	236	2009-09-11 07:37:51	2003-04-07 12:59:11	6	2	185	0	14	133	1	112.60	63	97.55	CHANGED	MNhshuhtGhsAPVKp+ua.asphshhshhphtthsh.AAl..hhh.tlu.hApupDLhAuGpssVKATFGtDS.VhhhlllAEllVGssMYhhTKNlhhLhGhsll.VFhsVGhshlt	..........................MsslLSVQGASAPVcKK.SF.FSK.F.TR...........LNMLRLs.R.AVIPAAV.L.MMF...FPpL..A.......MAA..p...G.pDLMASG.NsTVKATFGKDSSVVKWVVLAEVLVGAVMYMMTKN.V.K.F.LuGFAIISVFIAVGMuVVG.....................	0	0	1	10
+5342	PF05514	HR_lesion		HR-like lesion-inducing 	Finn RD	anon	Pfam-B_6954 (release 8.0)	Family	Family of plant proteins that are associated with the hypersensitive response (HR) pathway of defence against  plant pathogens [1].	22.60	22.60	22.60	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.65	0.71	-4.35	10	108	2012-10-02 13:32:46	2003-04-07 12:59:11	6	3	32	0	56	176	63	133.20	48	77.07	CHANGED	MuFlSFlGRVLFASlFlLSAaQEFsEF..GsDGGPAAKsLpPKaNhhssplosph....GhtVPpl-lKplVAAsIuLKGlGGLLFIaGSShGAYLLLlY.AhsTPllYDFYNYch-c.............................................................s-FspLFh+FsQsLALlGALLFFlGM	...................................................MuFhSFhGRVLFASlFlLS.AaQcFsEF..G.s..DG..G.PA.A..KtLp.P.K.h.sl.h.p.p.plo.spl....Gh.t...l..P.c.............l..-...lKp..llA.us..I.s..LKGlGGl...LF...l...hu..S.o..h..G..AaLLL.l..aLuh.h.TPI..l.YDFYN.Y.c.h.-.p............................................................scFspLhhcFhQNlALhG.A..LLFFlGM.........................	0	11	36	47
+5343	PF05515	Viral_NABP		Viral nucleic acid binding 	Finn RD	anon	Pfam-B_6916 (release 8.0)	Family	This family is common to ssRNA positive-strand viruses and are commonly described as nucleic acid binding  proteins (NABP).	21.50	21.50	21.50	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-3.85	8	209	2012-10-01 20:03:16	2003-04-07 12:59:11	6	2	29	0	0	374	1	97.30	38	84.68	CHANGED	MHPaDFN................................LLC.....................................CLH..............................FS+PsLPpDL+lhIastsssspKLsR+sppNKPFpGTSKCAtRRRAKRYNRCFDCGA..aLhcsHsCK..lFsSRApSDsLuVIHEGPAKLYAERoaR.NScAtQLItsDL.hhK	............................................................................................................................................................................................................................................a.p.GpS+sAtRRRA+RYsRCacCGu.......hhhss+.C+..hhsotups-sLtsI+cGss+LhuEp.................................................	0	0	0	0
+5345	PF05517	p25-alpha		p25-alpha 	Finn RD	anon	Pfam-B_6873 (release 8.0)	Family	This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase [1].  It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.33	0.71	-3.97	24	380	2009-01-15 18:05:59	2003-04-07 12:59:11	7	17	149	3	285	336	10	138.70	30	57.31	CHANGED	lcpsFcpFs.aG......pustp-Mcs+pFuKhhKDspll..spK.lTsTDsDllFuK..VKupss++.IsappF.ccuLsplApK+tt........pspplhpclh..tutuPthsu....spussVchhsDpopYTGsHKpths..soscsp..GhuGhtphsDco.........ptsshshph	.............................................................pp.FptFs.aG..........pusspphssppasKhh+Ds..tlh............Ds+...lTsTDsDllFsK.......l....K......u..+..ssc......p...Is..app..F..pcAl.p.c.lApc+ht........................ph.phhtplh.....tstsPthsu.......................ttsssspphsDpopYTGsHKpphs..tsscsp..uhuGh.phh-tp..................t.s......h................................................	0	115	149	205
+5346	PF05518	Totivirus_coat		Totivirus coat protein	Moxon SJ	anon	Pfam-B_10221 (release 8.0)	Family	\N	25.00	25.00	34.70	34.60	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	759	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.20	0.70	-6.70	7	23	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	20	0	0	24	0	622.50	31	97.28	CHANGED	LsuslssstuGshhss............ssaR+YcAtlphpusstGshpushssIaaElGt+ht........+sscshtssstpuhhl-suhs.sss.stsa.shsR+aps.......huspahhhslsullc+lutslAshslhssh.hsstuh+tspshpVsuLuohDu.psussuuV..alPpslc.shssclFslLh.sAsupGusVssDslpLDusTspPhlPslsssshttAhs.sLpllGu.MpuustGshaAhALTpGlHsVloVVuHoDEGGhhRDlLRpstap.PaGGlshuLp...pasulsshspsuhushsuhsDulALsTAAlVAHCDPh..hssshaPTlhssphsssst.ssu.........t...ttpltushs+FuphYhcuLuhhFultuss.thsspplhpAusphlstssp...RHLchsosAPaFWlEPTuLls.hshhGosAEttGYuuhshh.GssRopPsa-shchhGptsos.assaphchposRosshlshhss+PtsGLushcltphsssullLsG............ssssssstc+ttutssls-YlWtRGQoshPtPAEhhNhsuthslphRhhsas-Dtsss..pchPssc-hhcssVThpsst.hslssuspNstssts+RuRstuuptLsp....ARshGhssssph.Its.sPs.tss...st.shspsspsussspssss.sthsstshtssp.u.RGsPltssspHtshRAP.hsR...s.tGssshs.....s.ssss.s......................s.s..sssssss..hssssptsssstsp	....LsuslssspuGphhss............spaR+YcAslphsushtGshpsp.ptIhaElGtths........pttphht...ttuh.l-suhshsss.utpF.GhA++aoN.......Fuspa.h.slsuhsERlu+slAshslhss.....hs.sshttstshhVsuLuThDuP.su.tsuV..aIPRhlssshssclFsVLhtAssGpGuslsoDhlcLDsssppPhlPtlsssshstAhstALRllGuNM.sustGslFuhAlsRGlHpsloVVuHoDEGGhhRslLRpstFtsPaGGlp.uLp....asuLPshsssu.sshuuaVDulALtTAAhVAHsDPhh.hsGshaPThhsustssss.stsst...ss...stt.ttQlhushstFs..YhcuLutlFGhtsss...sttphhsshshhLstss....RHLchtoluPaFWlEPToLls.hshhGosAEttGhuuhsh..ssstshPsa-phphhupssss.aushthchposRpsshhstatspP.suLuslclcQhDssullhsG............sssps.sltc+htAssPlosYLWsRGQSshPAPuEhlNhsushGhhlRhhsas.--hsss..pclPsscEhhpssVohcVstPtGLs.sGssNttsppA+RARo+AsttLupuhhRARsaGtsssspM.l.sssPshts......t.thtphsttsh..st..t.s.shh.sts..s.t.s.pssPh.ss.ppts.chP.hst.hss..us.us.hss.s.s..s.sss.s..................................................t.................................................	0	0	0	0
+5348	PF05520	Citrus_P18		Citrus tristeza virus P18 protein	Moxon SJ	anon	Pfam-B_10309 (release 8.0)	Family	\N	25.00	25.00	249.60	249.50	17.30	17.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.04	0.71	-4.75	3	112	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1	0	0	101	0	151.10	95	100.00	CHANGED	MSGSLGNSTHVDLLRSDSRFLSGWWSFIVNVGDIIVRFALHVPSEDMLNSFSAISNCTIIADGSALLKDNTVVDRLESMNPLAYLLKLAKTTTTICFTMSNKVLFGTTKSEPLSCLAITSDRVLFKVIMGTNVDDSRCGCSIWFYNNGTFQNGLTRCNNLVALFSAT	.........THVDLLRSDSRFLSGWWSFIVNVGDIIVRFALHVPsEDMLNSFSAISNCTIIADGSALLKDNTVVDRLESMNPLAYLLKLAKTTTTICFTMSNKVLFGTTKSEPLSCLAITSDRVLFKVIMGTNVDDSRCGCSIWFYNNGTFQNGLTRCNNLV........	0	0	0	0
+5349	PF05521	Phage_H_T_join		Phage head-tail joining protein 	Finn RD	anon	Pfam-B_7008 (release 8.0)	Family	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.43	0.72	-3.70	131	1460	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	1110	2	227	1023	107	96.10	18	85.37	CHANGED	s+Rlslp........ts.ps..p-....s..sGshh....ts.a........tsht..s.lWAplp...sh..supEh.htussstup...h...shplplRa.ps.....sl....ssshR....lh......h.s....schapIpu....lschs.ptp.hlplhs	..........................................p+lph...t....h....tt..ps....s....sGthh.......pp.a........ht.hh........p..saAplp.......sh.....sup-h.....hpu.....ssp.tsp...s........shplhlRh..pp.........cl..........os.sh+...lt...........a..p..............sphasIts...lpssst.ppp.hl.lh......................................................	0	64	140	186
+5350	PF05522	Metallothio_6	Metallothionein;	Metallothionein	Moxon SJ	anon	Pfam-B_1360 (release 8.0)	Family	This family consists of metallothioneins from several worm and sea urchin species. Metallothioneins are low molecular weight, cysteine rich proteins known to be involved in heavy metal detoxification and homeostasis [1].	20.90	20.90	27.80	23.90	17.70	19.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.22	0.72	-10.69	0.72	-3.70	7	30	2012-10-05 18:33:37	2003-04-07 12:59:11	6	1	19	2	5	34	0	66.20	52	80.30	CHANGED	sssKssCs+-GppCsC.upppClpucCs.sscplCCu.....pCuNAuCKCusuCKCuuG...suCpcGsCss	......ssspssCs+EGppCsC.upCpChpu-Cs.ssccsCCu.......sKCGNAuCK.CGuuCKCuuG....suCscG.sCss..........	0	5	5	5
+5351	PF05523	FdtA	WxcM_C; 	WxcM-like, C-terminal 	Finn RD, Studholme DJ, Andreas P	anon	Pfam-B_6950 (release 8.0)	Family	This family includes FdtA (Swiss:Q6T1W8) from Aneurinibacillus thermoaerophilus, which has been characterised as a dtdp-6-deoxy-3,4-keto-hexulose isomerase [1]. It also includes WxcM (Swiss:Q93S92) from Xanthomonas campestris (pv. campestris) [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.58	0.71	-4.64	64	624	2012-10-10 13:59:34	2003-04-07 12:59:11	6	12	477	8	145	730	885	125.10	29	67.10	CHANGED	hss.p..llclspl....sD..RG....sLoslEtt.pp..lPFcIKRlYYlacVPsstt.RGtHAH+chcQhllslsGShclh.........LDDGpp+..pphhLscPt.hGLalsshlW+phhsFSss.uVhLVLASchYDEsDYIR-YspF.lphhp	.........................................thlph.th......tDt..+G....p.L.s...h.h...-t....p......l..P.F..p.lcRl.a.a.l.ass....su.hs...RG.tHAH.....+...p...hp.phhlsl.p.GS..h.p...lh.................................l..-..-...Gp..sp........pph......h..L...s...pss...pG.....L...h....lsshhW+phpsF.S..s.s..s..l.l.l..V.lA...schY-c..p-Y.IhsYp.aht...t........................................................	0	52	109	131
+5352	PF05524	PEP-utilisers_N		PEP-utilising enzyme, N-terminal	Finn RD, Studholme DJ	anon	Pfam-B_69291 (release 8.0)	Family	\N	21.90	21.90	21.90	22.60	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.29	0.71	-4.32	186	5872	2009-01-15 18:05:59	2003-04-07 12:59:11	8	34	3547	22	1028	3717	559	122.50	27	19.06	CHANGED	lpGlusSsGlAlGpshhhp....ttt..hphsppts.....tshpt.EhpR..hcpAlppsppcL.p..pltpp....h.tth....................s.....sspu.s.IhcuahhlLpDspLhpplpptIppsp.sAphAlppshpphtphhpshsDt.Yl+ERu	..................................pGlsuusGlAlGcu.hhltpsp..........hshpptsh..........pssst.EhpR.lpsAlppstppL.p.plpp+....h.tph..........................s....p-pu..u.IF-uHhhlLsDscL.hpplpph...I.pppp..sA-tAlppshcphsstapph.s..Dp..YL+ERA.............	0	310	592	817
+5353	PF05525	Branch_AA_trans		Branched-chain amino acid transport protein	Moxon SJ	anon	Pfam-B_1869 (release 8.0)	Family	This family consists of several bacterial branched-chain amino acid transport proteins which are responsible for the transport of leucine, isoleucine and valine via proton motive force [1].	22.30	22.30	22.60	22.50	21.50	22.20	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.49	0.70	-5.90	21	3775	2012-10-03 01:44:59	2003-04-07 12:59:11	8	4	2395	0	374	2332	41	418.00	37	96.77	CHANGED	pp+-hlhlGhMLFulFFGAGNLIFPPhLGhtuGpshhhAhlGFllTuVGLPlLulluluhsGt.ulcslus+ls.hauhlassllYLuIGPhaAlPRTusluFEhulsPhls....ssslsLhlaollaFulshhlSLpPuKllDplGKhLTPlLLlhlhlLhl.tulhpPhGshsss......p.stY.pspshhpGFl-GY.TMDsLAulsFGllIlsul+spGhp......sp+phhphslpuGlIAulhLullYsuLualGAsSsshh..........sssssGuplLsphspthFGshGpllLulllslACLTTulGLlousu-aFsclhP.tlSY+thshlholhShllANhGLspIIplSlPVLshlYPluIsLllLshhpphhpt..phsYpsslhhohlhull-ulpuhhhh........shlsphhphLPLtshGLuWLlPulluhlluhllsphp	.................................................................h..+chlhlGhMLFulFFGAGNLIFPPhLG.tAGpphahAhhGFllTuVGLPlLs.llAluh....s..ss.....ul.p.s.l....us....+ls.hauhl...as.sllY..LsIGPhFAl...PRTA.ol.oaElGlsPhhs................sp........sh.........s.........Lh.l.................FollF.FulshhloLpPuKllDplG+hLTPlhLlhlsllhl.tu.h.lp.P.h.......G..s.h..sss................s..ts.Y...ps..s..sFhpGFlpGY.TMDsLA.ulsFGlllVsul..+..pp......Gls....................ppppl.s+.hslh..uGllAulhLsllYhuL..salGupSs...shh...........stssNG.uhlLsphspphF.GshGp............llLuhllhlACLTTulGLlsAsu-aFpp.hh............P.....p....l.....S..Y.........+shlhlhs.lhShll.uNlGLsplIphSlPVLh.hlYPluIsLl.l..Ls.hh..p...p......hh...tp...p...p...h...s....a....t..h.s.hhhs......hlhu.lh-s....l.pss.s.h.........................shl.s.s.h..h.phLPLtphGluWllPulluhlluhlhs..h.................................	0	93	201	293
+5354	PF05526	R_equi_Vir		Rhodococcus equi virulence-associated protein	Moxon SJ	anon	Pfam-B_7324 (release 8.0)	Family	This family consists of several virulence-associated proteins from Rhodococcus equi. Rhodococcus equi is an important pulmonary pathogen of foals and is increasingly isolated from pneumonic infections and other infections in human immunodeficiency virus (HIV)-infected patients. Isolates from foals possess a large virulence plasmid, varying in size from 80 to 90 kb. Isolates lacking the plasmid are avirulent to foals. Little is known about the function of the plasmid apart from its encoding a virulence associated surface proteins [1].	25.00	25.00	31.80	31.70	22.50	17.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.08	0.71	-4.63	8	29	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	8	22	1	171.60	37	98.50	CHANGED	Mhchhh..su+sluustlsAsslh...APuGsAsApslssuusuus................susss.ththspssstshtstsssp-pQYsVHGsVsSAlVYQ+h+lsV-......sGcTF-GDAGGLohPGuuuhWGTLFTsDLQ+LYc-TVSFcYNAVGPYLNINFFDScGslLGHlQuGulSoVlG..IGGGoGuWc	.................................................................stthhs.hhsshshsh...sssGhAsAp.lssss.ss.................................sp...p.t..hspsssps.ttpsssp-ppYsV+GslsSAlhYQ+h..plpss......sGKsFsG-AGGlohPGuushaGTLF..TsDLp+LYs-TVSFpa.NAlGP.YLNINFFDupGslLGHlQuGulSTVsGlGGGoGuWp............	0	0	7	8
+5355	PF05527	DUF758		Domain of unknown function (DUF758) 	Finn RD	anon	Pfam-B_6320 (release 8.0)	Family	Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.	21.20	21.20	21.90	23.40	20.20	21.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.10	0.71	-4.68	14	241	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	96	1	145	222	0	178.10	50	91.04	CHANGED	h-sFsSKsLALQAQKKILSKMAoKohAphFIDDTSSElLDELYRloKEaTpN+pEApKllKsLIKlslKlGVLaRNsQFssEELtlspcF+KKl+psAMTAlSFaEV-aTFD+sVLuslLpECR-LL+plVppHLTsKSHGRIsHVFNHFuDs-hLssLYsPpusaRspLpKICsGlNKhL-EGsl	............-sFsSKsLALQAQKKlLSK.M.A.o....Kol.A.phh.I.DDTSSEl...L.DELYRl.oK......EaT.p.....s.....KKEAcKllKsLIKlslK.lulLaRNsQFst-.ELslh-+.F++Kl+..phAMTslSFap........V-aTFD..+....sVL....uplLpEC+-lL+plVp+HLTsKSHGRIscVFsHFuDs-FLssLYs...P.....ss.a+s.pLp+IC-GlNKhLDEtsl..............	0	31	43	77
+5356	PF05528	Coronavirus_5		Coronavirus gene 5 protein	Moxon SJ	anon	Pfam-B_7342 (release 8.0)	Family	Infectious bronchitis virus (IBV), a member of Coronaviridae family, has a single-stranded positive-sense RNA genome, which is 27 kb in length. Gene 5 contains two (5a and 5b) open reading frames. The function of the 5a and 5b proteins is unknown [1].	25.00	25.00	28.70	30.50	21.30	16.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.95	0.72	-4.16	2	99	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	13	0	0	100	0	80.40	87	99.62	CHANGED	MNNSK-NPFptAIARKARlYLREGLtCVYFLNcAGQAEsCPsCTSLV.pGphC-EHl.NNNLLSWpAV+.LE+QTPpRR.SN	.MNNSKDNPFRGAIARKARIYLR.EGLDCVYFLNKAGQAEPCPACTSLVFQGKTCEEHIsNNNLLSWQAVRQLE+QTPQRQSSN...............	0	0	0	0
+5357	PF05529	Bap31		B-cell receptor-associated protein 31-like 	Finn RD	anon	Pfam-B_6449 (release 8.0)	Family	Bap31 is a polytopic integral protein of the endoplasmic reticulum membrane and a substrate of caspase-8.  Bap31 is cleaved within its cytosolic domain, generating pro-apoptotic p20 Bap31 [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.22	0.71	-4.84	40	599	2009-09-11 14:14:48	2003-04-07 12:59:11	7	10	290	0	357	535	7	181.30	24	83.77	CHANGED	MoLhaoLVFshLhsEhshhhlLslPlPpslR.+plhphhttshhspphphshhhhlshlllLFlDulpRlh+hssphpttpsspssss..........sphp..u++FauQRNhYloGFoLFLoLllsRshollpcLlphpcphcshppptpttsttt.................................tppsttssElpcLKcclpp.......ccpDlcsLKcQscsLp+EY-	..........................................................................Msl.ashl.hhhLh.sEh.slhhlL.hl.Ph..shR....pplhp............hh..t.h..h..st..hhp..hhh..............hhlhshl.l..l...L.h..l.Dulp.c.hh+hssphp...tptpstss...............................h..p.h.h+hF.huQRNhYl..s..GFsLF.Lsl........l..lpRlh..sl..l....p....plhphpsp.hcshpppspst.t..pttt...........................................ttttt.tt-.htpLppclpt.....................tptch...sh..+pQsctlpp-ap...................................................................................	0	105	188	282
+5359	PF05531	NPV_P10		Nucleopolyhedrovirus P10 protein	Moxon SJ, Bateman A	anon	Pfam-B_7343 (release 8.0) & Pfam-B_6199 (release 10.0)	Family	This family consists of several nucleopolyhedrovirus P10 proteins which are thought to be involved in the morphogenesis of the polyhedra [1].	29.80	29.80	29.80	29.80	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.65	0.72	-3.73	21	81	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	63	0	3	70	0	77.80	37	77.83	CHANGED	MS..NILlhIRsDIpslssKVsuLQspV.......sslpsNlPshp.l.ttLDAQospLsslpo..............pVssIpsILs.................P-lPs	....MS..pNILhlIhscIpslssKVs.......uLQspV...........sslcssl....ss...l.tpL....Du.sspLsslps..............pVssIpslLs................hP-lP...........................................................................	0	0	1	1
+5360	PF05532	CsbD		CsbD-like	Finn RD	anon	Pfam-B_6755 (release 8.0)	Family	CsbD is a bacterial general stress response protein.  It's expression is mediated by sigma-B, an alternative sigma factor [1]. The role of CsbD in stress response is  unclear.	40.00	40.00	40.00	40.00	39.70	39.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.42	0.72	-4.29	119	3357	2012-10-02 00:15:32	2003-04-07 12:59:11	7	3	2275	2	706	1779	71	53.50	36	76.85	CHANGED	-clcGphcchpGcsKEshGchTsscphpsEGctcpstGcspcphucsK...-tscc	.........thcuphcphKGplKEshG+lTsDcphp.tEGct-pssGKsp-thspsK-psct..................	0	169	400	559
+5361	PF05533	Peptidase_C42		Beet yellows virus-type papain-like endopeptidase C42	Studholme DJ	anon	Merops	Domain	Members of the Closteroviridae and Potyviridae families of plant positive-strand RNA viruses encode one or two papain-like leader proteinases, belonging to Merops peptidase family C42.	25.00	25.00	27.40	37.70	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.20	0.72	-4.16	8	200	2012-10-10 12:56:15	2003-04-07 12:59:11	7	8	8	0	0	172	0	73.20	66	10.95	CHANGED	tchtDGhCYlAHhthlCAahsRsFccpDa....sLGsaPTVucL+sRlh+paGccALplslRGtYoSRslFHCDYsuuaspsh+slsua..lGG	.A.KlRDGQCYlRHVYDVALYFGRRV..DLSV+...RTLGhFPTVGALKAYLVREYGR-SLKVPMRGTYT................................................	0	0	0	0
+5362	PF05534	HicB		HicB family	Moxon SJ	anon	Pfam-B_6090 (release 8.0)	Family	This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches [1]. 	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.41	0.72	-4.39	24	1200	2012-10-02 18:44:02	2003-04-07 12:59:11	7	4	929	0	259	814	64	48.00	32	43.10	CHANGED	YlpsCpp.GhpPc+taS..GpFslRlsP-LHccluhtAtppslSLNpalppsL	.......................t.p....t.....s..t.t.hp....t....p...FsLR.lsppLHccLshtAtppslSlNpalhphL...........	1	79	171	225
+5363	PF05535	Chromadorea_ALT		Chromadorea ALT protein	Moxon SJ	anon	Pfam-B_7314 (release 8.0)	Family	This family consists of several ALT protein homologues found in nematodes. Lymphatic filariasis is a major tropical disease caused by the mosquito borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangitis and elephantiasis. Expression of alt-1 and alt-2 is initiated midway through development in the mosquito, peaking in the infective larva and declining sharply following entry into the host. ALT-1 and the closely related ALT-2 have been found to be strong candidates for a future vaccine against human filariasis [1].	25.00	25.00	34.70	33.80	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.10	0.72	-3.89	6	43	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	13	0	24	44	0	75.70	56	34.20	CHANGED	EalsKGcFVETDGKKKpCcoHpACYDQREPQuWChLKps.QuWTs+GCFC-pKh+uCVIER..psssKLEYoYCuPccsWpCu	..............ss+GcFVcTDG+cKpCpSHpsCYDQREPpuWChLpcN.QuWTs+GCFCDsKL+SCVIER..pN....s....G+L....EYuYCsPcpsWpCp.......	0	16	16	24
+5364	PF05536	Neurochondrin		Neurochondrin	Moxon SJ	anon	Pfam-B_7411 (release 8.0)	Family	This family contains several eukaryotic neurochondrin proteins. Neurochondrin induces hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain [1].	19.10	19.10	19.10	19.10	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	543	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.72	0.70	-6.20	8	217	2012-10-11 20:01:00	2003-04-07 12:59:11	6	15	138	0	160	237	0	430.60	20	74.69	CHANGED	psssssL-cCLpLL+up+.Dop+FAuLLLVTKhl+usDhsuts+chlF...-AVGhpFLcRLLpotp...ussss....sccsahsLulolLusFCs..-PElAscppVls+IPhls-slppsss......hshl--sYpsLsulu.uoPpGs+sLlstGslshLsptYss...puashEpAlplLhsLlsshcspshp.-c..thpsllsplucpFssh-sspKFEL...hclLsslLspp....l...lpS..upphhcpLptGlssILps+losupRssALpLAAsLhps...hGspWlhsssp..............ss+FlhLllsluslEVRhsLsE.............pspshtp+pcslosCauLlEhhIphhsc..pt-psll-.....csphhpLhssLpEshusVlcaLpcst-................................-p.+-s.......hllAuVRlLGuWLAE-ssu.h+pclppLLsFhlclt+csapp...hpt...................shDulRalLPuLCplosEccsp+lLhspGusplLsD......sl.............lphhcc.ps..s...suEh.....ul.hhCshhhNlllstssh.hpctusFsuLh+sLlp...........................................................sssusctsslhhSsuhpuhWtDl...sphW	...........................................................................t......htph.thLpttp.DppphsuLhhlpphhp..s.tp..t.st.........lh.................culu...pF.p+LL.ot...............tt..............................t.hhtlulslLtsast.........phttp..ph.hstlPhl.phltttss..........................thhp-shphLhsls.up.tG.pthht...ssls.hlsphh.t............................psh....h-..shtlhhhl.ht..t..ht.......h....pt...h..tl.h.tt....lu..ht.t.psttthph.....................hphLs.hl......................................h..pl..hl.tll.ts.+.s...t................+..h.h.lhtthhph....hu.phh..t...................................t.ahhlllp.hhl-lph.h.p............................h.....tp.ls.sa.lhp.hlt...h.p........tt.....t..............................................h.phhp.hptshshhhthL.t..ph.........................................................p..t...pc..................lhu...lRhls.altpps.t.hp.th....tlhshhhph.tt....t........................................................................hphhLshhpthsh.......p.tstphhht...tt.thlhp..........h.....................................................t.........................................................................................................................................................................................................................................................................	1	53	94	131
+5365	PF05537	DUF759		Borrelia burgdorferi protein of unknown function (DUF759)	Moxon SJ	anon	Pfam-B_7415 (release 8.0)	Family	This family consists of several uncharacterised proteins from the Lyme disease spirochete Borrelia burgdorferi.	19.90	19.90	21.30	20.10	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.61	0.70	-5.71	2	148	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	27	0	12	135	0	319.00	50	87.42	CHANGED	MSDKFTIKFKGILDHAATKKAIEQDISKMEKYLKPKKSSLGSTKDIVKNNLSDKKKELS+QSKFESLRERVEKYRLTQTKKLhKQGMGFEKARKEAF+RSLMSDRDKRRLEYKELAKESKAKSKMLAASQGKGLVAKIAIGSALGNlIuNAMSKVGGGLlGF....hKKuVE-soKpc+hQ.LNpshYGs.KE+-slLK.IGtMKGFcRsLEKE-FLppA.VhKGslR-Lc.LN-...pNlhNAschAAMh+SoGhhS.sEsuVpAVsplLtG-hoEhashLK..sthG-KYlEshK.th....QpGuplcLcscI..hh-hhKDhpShtlhthssshEphpssLAshEQTLpsLTssVLcPllslIs.hhsK....ItNFs.hpslINsIhNuIpShhsh...FsKl+uhLPphhGGsGs-s....p..scspsssNs	.......................MSDKFTIKFKGlLDHAATKKAIEQDIoKMEKYLKPKKSSLG.STKDIVKNNLSDKKKELu+QSKFESLRERVEKYRLTQTKKLhKQGMGFEKARKEAF+RSLMSD+DKRRL.EYKELAKESKAKsKMlAASQGKGL..VAKIAIGSALGNlIuNAhSKVGGGhlGF....hKKuVEppoKpc+hp....LNpsha.........sc.c.........E+........ptlh......t.......hltt......hKGFERcLEKE-FLppuolhKG.slp...-Lp..LNp...pNlhpAschAAhh+SoGhhu.sEpAlpsVsphLpG-hsphaphhp....sthG..pKYhEshK.th....Qpuu.ph.chc.cl..hhchh.pDhpShtlhthusphpphpssLsphEQoLtslTssllpPllthlp.hhth.....h.tap....ptllt.hh....pu....l....pshhs....................................................................................................................................	2	7	8	8
+5366	PF05538	Campylo_MOMP		Campylobacter major outer membrane protein	Moxon SJ	anon	Pfam-B_7418 (release 8.0)	Family	This family consists of Campylobacter major outer membrane proteins. The major outer membrane protein (MOMP), a putative porin and a multifunction surface protein of Campylobacter jejuni, may play an important role in the adaptation of the organism to various host environments [1]. 	19.90	19.90	21.00	20.90	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.48	0.70	-6.10	2	514	2012-10-03 17:14:37	2003-04-07 12:59:11	6	2	136	0	23	333	1	274.10	49	99.06	CHANGED	MKLVKlSLVAALAAGAFSAANATPLEEAIKDlDVSGVLRYRY-ouN..pNhs.sSslss.KQDHKYRAQVNFSuAIuDNFKAFlQFDYNu.DGGhGsDsloNspcsLhVRQLYLTYTNEDVATSVIAGKQQLNhIWTDNuIDGLVGTGlKVVNNSIDGLTLAAFAhDSF.ttppssshlsQss.pphp............pssshtlD.stNlYGAAAlGSYDlAGGQFNPQLWLAYhspsAFhYAlDAAYSTTIFDGINWTlEGAYLGNSlDscLcD+hc.ANGNhFAL+GolEVNGWDASLGGLYYGcK-KsohssIEDQGNLGSLLAGEEIFYTsGSpLNGDhGRNIFGYVTuGYTFNETVRVGADFVYGGTKTp.hup..GGKKLEAVARVDYKYSPKLNFSAFYSYVNlD...sssESscHssVRLQALYKF	...............................F.S....s.AsPLEEAIKDlDVSGVlRYR.Y-os.........p.p........p..s....h.......s...........p.s....s.s.......ls.......s.KtpHpa+uphsFpu....AlsDN....Ftuhl...........ph...pY.s..s........-.......s......G..........h....G.........h.............s...t...........h...........p.......s...s...........p........p.t...h....VpphYLsYTspsh.s.TolhhGKQtlshhaT...Ds.s....sGTGl+VlNssIsGLTLA.uhAhDuh.tt...t.............................................................tslYususlGsa-.....hs.QL..WhAhhsp.s..u..h...a.......A...h.Dhshph.hhsshshtlputYhtsshD.sp.......htt.............................................s....suN......hauhphshph.shDhthGh.l..ha..t..pc.p....c....h..o.hsslEDpGph........hh.......sGt..plh....s..ptpt.h..s....ucN....ah..ahthGYoF.sc..hplGh-al.Gt.ps...............t..cc.......E...hssplsYtYS.KLsh.saYuh.hp.....................................................................................................................................................................................................................................................................................................	0	6	14	23
+5367	PF05539	Pneumo_att_G		Pneumovirinae attachment membrane glycoprotein G	Moxon SJ	anon	Pfam-B_7428 (release 8.0)	Family	\N	25.00	25.00	83.60	83.60	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.71	0.70	-5.09	3	103	2009-09-11 11:15:31	2003-04-07 12:59:11	6	1	3	0	0	83	0	160.30	60	99.79	CHANGED	MGSKLYhIpGsSuuQlslKpsL+lucKllLuIVLSALGLTsToTIALSISISVEQuVLc-C.cTYhusssohaSsosspsTTTsoATTT+DhRGLQTTRTRKhESCuaVQIuYGDMHDRSssVLGGlDCLGLLALCESGPICQRDsps-DsshCRCTlcu+uVSCCKcPKousTTSpTTScPscs.osPsaPSQcsocScPsoQGcQT....oTAspploSTsshhTpcTuTsosucPQspPsPSppG.osos+csuSTsSpcooT.sGsupcHTQRh+TPPos-NsRoshppsTP..TT.hacTt+PTP+PTs-hpsssp.spoSPsulQuNPTTQ.N.lsCcchDPscPp+ICYpVGoYNsulo+sCcI-VPLCSTYspsCMcTYYocPFNCWRRspRClCD-GsGLIEWCCTS	...............................ch.p+hlLulVLSAhGLThTsTIslolsl.VEQshLcpC.csY.utstshassppppsTos.stTssts.ttLQsststK.ESChaVQls.GDMasRS.sVL..........................................................................................................................................................................................................................................................................................................	0	0	0	0
+5368	PF05540	Serpulina_VSP		Serpulina hyodysenteriae variable surface protein	Moxon SJ	anon	Pfam-B_7432 (release 8.0)	Family	This family consists of several variable surface proteins from Serpulina hyodysenteriae.	22.90	22.90	23.10	44.80	17.40	22.80	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.34	0.70	-5.69	4	43	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	5	0	26	43	0	353.80	47	99.32	CHANGED	MKKhLLsslAlLTIuSuSsFGMYGDpDsWIDFLTcGNQFRARMDQLGFVLGNsTIKGTFGFRoQslsTtLGsIl.oGNstNhs.LpsTISsGIGYTS-sFGIGlGYNYTY.........hssslGsHTPVLMlNALNNNLRIAIPVQIAVp+DshsKhs.....pspKDYLGISTDhQIRYYTGIDAFNtIRLYhKYGQsGYKss.....NsspEhFAQShGFEsRhYFLNTslG.NVTINPFIKVsYNTAL..+GsushVRAu-ohhss.....stsh.s.cP............th-.KaD+NPYDVpstAVLGlTANSDhVSLYVEPSLGYpApYhGKhto-p..h....KVpHsLhWGAYAELYIpPVQDLEWYFEMDlNNusS+.......p.sulPVsFuooTGITWYLPtL	............................................................MKKhhLhhhslLohu.sSlFGMYGsp.-sWIDFLscGNQhRARMDQLGFlLGNsTIKGTFGF+.upo....h..s.lGpIL..s.....s.spssht.LtsTISuGIGYTS-sFGIGlGYNYTa..........hu.sshssHTPVLhlNALNsNLRIslPVQIuVpssshsphs.........ppsYhGlS.T.D.sQIRYY..T..GIDAFNtIRlalKYGp.saKss.............................shs....p-hhApShGF-hRhYFLNTslG.NVTlNPFl+VsYsTAL...pGh...uphlts..h-..shhps...............h.th.sstssst................................ssh.sthaD+sPYclsltssLGlTANS..DlVSLYlEPuLGYpsph.h......G+h.ss.tst.........Klp..HtLuWuAYuELYIpPVpDLEWYFEMD...VNNussp.......p.sul......PVsFsuoTGITWYLPth............................................................	0	7	7	7
+5369	PF05541	Spheroidin		Entomopoxvirus spheroidin protein	Moxon SJ	anon	Pfam-B_7488 (release 8.0)	Family	Entomopoxviruses (EPVs) are large (300-400 nm) oval-shaped viruses replicating in the cytoplasm of their insect host cells. At the end of their replicative cycle EPVs virions are occluded in a highly expressed protein called spheroidin. This protein forms large (5-20 mm long) oval-shaped occlusion bodies (OBs) called spherules. The infectious cycle of EPVs begins with the ingestion by the insect host of the spherules, their dissolution by the alkaline reducing conditions of the midgut fluid and the release of virions in the midgut lumen. The infective particles first replicate in midgut epithelial cells, then pass the gut barrier to colonise the internal tissues, mainly the fat body cells. Whilst spheroidin has been demonstrated to be non-essential for viral replication, it plays an essential role in the natural biological cycle of the virus in protecting virions from adverse environmental conditions (e.g. UV degradation) and thus improving transmission efficacy. In this respect, spheroidins are functionally similar to polyhedrins of baculoviruses or cypoviruses [1].	25.00	25.00	61.80	61.20	21.70	21.30	hmmbuild  -o /dev/null HMM SEED	944	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.53	0.70	-6.94	4	11	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	11	0	1	11	0	866.40	39	92.91	CHANGED	sNlPlsscpIpKlsspKYEl+hhLKD-sppF-+h.l-hVVPLYDsss.houVTlESsssslEllELDpTHhRlhl+ssshcEhsa.hsFsssVsp-pVWKYlocLLLsNluhsssKhKLsNaplsLNsKHlphpclcpsLFIhFhDD.GhYGLIT+cNI.NssL.VsKDAoaIplFPQahYhphGRclYlNEKsThDVss-ssNlsLDhpKSVNIuVS...FlsI.YElssstQKcLLKsLlp+YGcFDVYNADTGLlYAKNLsIKs.sT.VIQV-+lPVpLKVKAYhKs.sG+sLChh+ITSST.sDPEYVsSpsAhLGsL.pVYKKFc...+ShLKlhhHscsosNVhPstsLhLELsDspsYshKsSssSRLsVGlYKlsKIYlcNscspIhLcpIcscacCs+pla+EhspL.+................cps+YTscs.FpIlsNsPchslalaG.IpNlsh+sKsshNL+LWGWIlcsDsSRal+hhsDGSlDLDLshKhspsDlsLhpAl+p+YhNslILEhANsY.ssslSLGNp+FpNIFDMc.cscoIspYTNFTKsRQDLNNhuClLGINIGspVNIpsLP..GWlss+EhcILp.Susscl+pFscuFCclsN+RFasMA+DllSLLFMCNYlNIEIsEulC-YPGYllLFARAlKVINDlLLlNGlspLAGYSISlPlcaGss-KTLPpp+pGGV-K+FKchFLKspL+-LM+Dp-FVQsPLYISTYF+ol.-sP.o-NYEKYLl-SusQSQ-lLQGLLNTpNo.DTNARVsSSVhG.asY......-.ssTuEacIu.............................sEALsKhsK.ho+.GNhGLlN+lsE....pC...s.cGh.-Nppl+sph.pp.FsCpPNNNsELIs+YGY+lhDLc+ItplhsshDs...sspcpshh.E-pt.h..s..h.h.a.....spssp....phs.ClppN.pp+ha.pcCscssoCs+......Rps........h...sGYc+sH	..........NIslplh-lpplNDupapV+Fs...-shpFstK.hshVVP.YssD....hVslEouDsNl.l.-hspT+Y..lhapsptsEhshhFoFsssVDp-plhpYlopLlhsNLu.hssK.hlhNhslhlNGhh.shhthspshaIhhaspssshhLloppsIhNpoLlVsKDsoalpl.sQ+lhsactphlYlsEpsT.DVs.sVsNlVLDL+puVsluVS...FlShshEls-ssQKcll.SLlp+hGcFDlhNADTGhVYt+NLslKpssThsh.V-p.sV+lpsKshhh.hcs+slp.hplhSs...Ds-YVsscouohthL.olYhKhhptIKSLLKIhhpDccssshh.GhshslEhpDhNshshphossoRLslGlYplchlYLsspcDpIp.phIc.........aK-YVs.sca-..............p-G+YpshssFhIhuNpPhIslalhGcIhsss.cscsshpLpLhG..lDhcsShY...as-suLsL...a+pcsssloLhcAlKh+alNsIlhcsANhh.sGsIolGN+Ka.NIhDh+tDscTlNpYsNhhhu+pshNs.uslLulslss.VNIQ-LP..sWLss+....LusSusD.l+shlpuFss.ss+caashs+sIlSLLhhsNaINhpIc-oLCcYPGhIhLFARhhKhIN-hLhl.G..phAhYSloh.scauss-phLPas+ptGl.KcFh+pahKsshpsLM+Dcsa.QsPLhI.s.hpslpps.....ssNhtp.lss.......SAsps.sLlptLLsopNspDsss+.Vl.SshGuF..........sNhu-pcIs.............................ppslSpllchhp+sGshGLl.+.s................-NpsI+ph+spspF.sp.Ns.scLIphhuap..DhpthhchhsssD-lP.ssscpshh-EDpt.hh.s..hsh.as....spssp.......s.Chpspspp+hh.spCspsssCs+.......+ps........a...sGh.hsH..............................	0	0	1	1
+5370	PF05542	DUF760		Protein of unknown function (DUF760)	Moxon SJ	anon	Pfam-B_7508 (release 8.0)	Family	This family contains several uncharacterised plant proteins.	20.20	20.20	20.60	23.20	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.61	0.72	-3.80	54	380	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	117	0	216	365	110	97.80	30	44.47	CHANGED	ssLhpYlpphpP.-tlsplsc.............................................ssSs-lhpshcps....lpullGsL..P...................................sttFpsplpss+-pLupLlhushMoGYaLRphEpRhpL-psLp	...............LhchlpplpP..-plpplsc.............................................ssSs-lh-hhcps....lpslLGhl...P......................................spphsshlpss+ppLup....Lhsu.uhMsGYaLRphE.RhpLEcsL...................	2	48	141	188
+5371	PF05543	Peptidase_C47		Staphopain peptidase C47	Studholme DJ	anon	Merops	Family	Staphopains are one of four major families of  proteinases secreted by  the Gram-positive Staphylococcus aureus. These staphylococcal cysteine proteases are secreted as preproenzymes that are proteolytically cleaved to generate the mature enzyme.	21.60	21.60	21.80	24.20	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.85	4	395	2012-10-10 12:56:15	2003-04-07 12:59:11	8	3	221	9	4	118	0	172.80	60	44.73	CHANGED	shpsQYVNpLKNFKIRETQGsNuWCAGYTMSALLNATYNTs+YNAEuVMRaLHPNLpGc-FQFTGLTPpEMl+aGpSQGRssQaLNRMsSYNEVDpLTpNNKGIAILGpRVESs.sGhHAGHAMAVVGNAKlNNGQ-VIlIWNPWDsGhMTQDAcSNlIPVSNGDHYpW.uSIYGY	.........p..p.QY.NpLcNFKIREpQhsNuWCAGaoMuALLNAThNTspYpAcslMRhLaPplptQch.....s.u....hhP..p....pMIpa.GpoQ.GRs..ph.pths....o...YNpVDpLTKsNhGIhlLup.pVppp....Ns.HhGHAhAVVGN..AKlNs........QEh.....lIhWNPWDsth.hQDAcss..ll.lS..sccYpWYuShhGY...............................	0	2	2	4
+5372	PF05544	Pro_racemase		Proline racemase	Moxon SJ	anon	Pfam-B_7562 (release 8.0)	Family	This family consists of proline racemase (EC 5.1.1.4) proteins which catalyse the interconversion of L- and D-proline in bacteria [1]. This family also contains several similar eukaryotic proteins including Swiss:Q9NCP4 a sequence with B-cell mitogenic properties which has been characterised as a co-factor-independent proline racemase [2].	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.77	0.70	-5.60	14	1248	2012-10-03 03:02:41	2003-04-07 12:59:11	6	8	740	7	380	1522	561	313.20	35	95.24	CHANGED	llDsHspGEssRllsGGssslsGsThhE+ppahtp-h..DtlRphlhhEPRGpshhpuslLhPPpcP-AshGhlhhEsssh.sMsGpsoIslsTsLlEsGllshp...pPtscl...L-sPuGlVcspscscsG...psppVplpNVPSFhathDstl-VsGl.GclpVDlAYGGsaaAlV-spphGhslssspAp-Lsshu.tlppAlscphth.HPcts-hstlsas.hsussspsps..suRNsVhhsstthDRSPCGTGoSARhAsLtA+GpLcsG-palpc.SlIGStFcG+l.thscluG+s............AIlPpIuG+AalTGhsphhlDPsDPaspGap	...............................lDsHssGEPsRll....h...u..G.hP..pl....G..tT.hhE+p..p.a.........h......tp.ch...........DtlRphLhhEP.RGassM.GulLs.P..Ps.......c....s....c.ADhGV.lFhcs......s......G.h.h.s.M..CGHuoIulsT.s.hl.E...p.........G..hls.s.p...........ps..t.....p.....hh..l.-.o..P.uG.l..V.ps.ph...p.h....c.su........cst...pVohp.N.V......Pu......Fh....h...p...p...sl.p....l.........-l...........s......s.........h.G......p.....lp.sD........lAaG..Gs.aY....ulV-....spp.h....G..h....c...l..ssp.s.....sppLhphuht....l+p..sl....pp....p....h..t....h.....H.Pp.t..slptlst..l.hh...ss.....s.....pptts...............ss+NsVhh............s.....s............s...t............l............DRSPCGTGT.SA+hAtLhA+GcLphG-.p.ah.pc.SI....l....G...S.h......F.....pGc......l....p..t.....s..p..l.u...s.h..............AllPplsGp.AaloGhsphhlD.s.p.DPhstGF......................................................................................................................................	0	106	211	297
+5373	PF05545	FixQ		Cbb3-type cytochrome oxidase component FixQ	Moxon SJ	anon	Pfam-B_7570 (release 8.0)	Family	This family consists of several Cbb3-type cytochrome oxidase components (FixQ/CcoQ). FixQ is found in nitrogen fixing bacteria. Since nitrogen fixation is an energy-consuming process, effective symbioses depend on operation of a respiratory chain with a high affinity for O2, closely coupled to ATP production. This requirement is fulfilled by a special three-subunit terminal oxidase (cytochrome terminal oxidase cbb3), which was first identified in Bradyrhizobium japonicum as the product of the fixNOQP operon [1].	22.80	22.80	22.90	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.19	0.72	-4.32	127	974	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	905	0	280	665	58	46.80	27	73.61	CHANGED	h..............shhpuhhslhhhlhFlGllhWAa.pspp..+ppa--AAplPFc..--	........................shhpuhhslhhhlhFlullhasa..pscp...+ppa--uAplshp.D-...........	0	64	169	223
+5374	PF05546	She9_MDM33		She9 / Mdm33 family	Wood V	anon	Pfam-B_35269 (Release 8.0)	Family	Members of this family are mitochondrial inner membrane proteins with a role in inner mitochondrial membrane organisation and biogenesis [1].	20.50	20.50	21.00	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.31	0.70	-4.78	17	144	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	138	0	112	152	5	193.70	44	44.52	CHANGED	pphu..++hphhhDslQpslhsAopsLNDlTGYSuIEcLKpsIpphEpcLcps+ppl+psKttYspAIpcRSpSQREVNELLpRKcsWSPsDLERFTpLYRsDHsNpppEp-uppcLp-uEpcs-plpspLhpuILoRYHEEQIWSDKIRRsSTWGTahLMGlNllLFllhQLllEPWKR+RLVtuFE-KV+pAlct.tpppphthpphl	..............................s..hscphsphhDslQsslhsAsppLNDlTG..YSuIEpLKpplpt.Epclcps+ppl+pAKpsYpsAlspRusSQREVN-LLpRKcsWossDLER.FTpLYRsDHtNEptEtcupptLspAEpct-chtspLtpuILsRYHEEQlWSDKIRRhSTWGTauLMGlNllLFllhQlhlEPW+R+RLVpuFE-+Vppslcc.pt.........th.......................	0	32	65	98
+5375	PF05547	Peptidase_M6		Immune inhibitor A peptidase M6	Studholme DJ	anon	Merops	Domain	The insect pathogenic  Gram-positive Bacillus thuringiensis secretes immune inhibitor A, a metallopeptidase, which specifically cleaves host antibacterial proteins. A homologue of immune inhibitor A, PrtV, has been identified in the Gram-negative human pathogen Vibrio cholerae [4].	23.70	23.70	23.70	23.70	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	646	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.02	0.70	-6.49	5	820	2012-10-03 04:41:15	2003-04-07 12:59:11	6	51	467	0	195	739	218	459.10	29	56.97	CHANGED	susQssasGsVRoDKVLVLLVEFuDhs...........HNsIsKpss.....pMYp-DYspEHYQDMLFGccsYoh.cGcslpShKQYYEcQSGGSYoVDGpVocWl+VPtsAAcYGuN.usGsDNpuP+uARDLVKEALc.......sAs-pslDLoQFDQaDRYDhNGDGNhNEPDGlIDHLMIIHAGVGEEAGGGsLG-DAIWSHRapluscshulEGTpusVs....haGGchAAaDYTIpPEDGAlGVaAHEYGHDLGLPDEYDTpYTGsGEPVuaWSlMSSGSWuGKIuGTEPTuFSupsK-FhQKslGGNWhNh.plDhsKLssspG+sssLDQosTKSsRPshV+VsLPpKoVEsIKPApGcatYYSs+GDDL+NTLST.slDLTsuTsAcFcFKuWY-IEADYDFlcVch..VopDGspThh-csGcpssssstcsss.....sGK...WIDtsYDLSsatGKKVcLpF-YlTDGGLAMcGFhlD-luLTVDGcssFSDDAEG.TSpasLsGFT+suG..T+cpsHYYllEWRNHsGoDsGLtp.........h.+aucthuYssGLVVWYsDsSYADNWVGlHPG+GFLGVVDSHPcALVhspsGclAcs...RaQltDAAFShcKTsuhplso...uTsuTasssuLuussoFDDc+sYhspQlPDuGRKlPchGLKhcVluQAcDsSsGsV	....................................................................................................t.............phhslLh-asD.......................................sth....t.............h......p...a..taapphh...as.p.................................u...p...p...h..........oh+pYapppSsspass........s....G...t.l..t......t.Whps.s.tptu...YGss.......s.s....p.........s................s....................s.......t...sp-h.lp-Alt.....................hsh..t...sh.slupaD....ctYD.susGs.pp.sDG.hlDplhllH.AGhGp...ps.G..G....G.h......t....s......s..AIWuH+......t...h....s............t................h......s..h....p..G.....sp.......th.................hhs.s.th...t.s...h..-...Y.....s......h..p.............P...........s.......u........u......hGVhsHEaGH.s.L.G.LPD.Y..D.T.............s...G...t.s..........p...s............l.....t.WolMuuGS..W.....s..G.......ph....s......s.s.t..ssshss....pt.a.p.th.....s....W..hp................h......t..t........................................................................ts.....Gp........aaSs...pu.ss.h...p.s....p...hpp......h....slst...s.s...p..A...p...h...phc...shaplE.........t.....p.......aDah.V....hs.sGt.......shhp................h....p...s......s....t..sts.........................................st........WhchphD.L..ota..tG.p.p.l.pltFpYhTD........uh......s.......h......p......GhhhDshtl...p......s...st..hh.sshc.....s......th...........h.........................G..a.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	83	136	171
+5376	PF05548	Peptidase_M11		Gametolysin peptidase M11	Studholme DJ	anon	Merops	Family	In the unicellular biflagellated alga, Chlamydomonas reinhardtii, gametolysin, a zinc-containing metallo-protease, is responsible for the degradation of the cell wall. Homologues of gametolysin have also been reported in the simple multicellular organism, Volvox.	20.60	20.60	21.40	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.17	0.70	-5.50	6	219	2012-10-03 04:41:15	2003-04-07 12:59:11	6	11	37	0	180	218	11	252.00	23	45.09	CHANGED	RLLVhILDYSoC...Ga..usolTE-plRslFLGPNpDGsGGlApKYspCSYsKFuLN.sTAFhsVt.VslsCoosVT................uoCS...........WWslSp............tADsAA+All.............GlsAF..uoFoHasYVLPPGlp..CuWAGLAll.P.G+psaLpoSuYGlpRWu......TlMQEAlHNYGLWHSWRNshEYEDaSTAM......G....RGsACPNAuEhSRlGWATP...........AsGG.Gslsuushsss....GostsasLPAThlTGDsNaLRV...lPsWLsshhNuTsAKNLYluhRVsKsG....DuALsupausKVpVHEVNATMDN.uhsspahpSDR+IpFluusssho+usLsA	....................................................................................................................h...h...................................s..htthh.t.CShsph.h....t.s.......hhh....l....s.Cts.............................................ps.s........................h...h.shtt.........................h.u.c...th.s...ps................G....sh.......ss.ap...+.hhalhP...s..t...........C..s....a..s..G.....hu.l....s....G..p............s.h...h.t.h.s..s....h......p..h.s............................slhpEhhHNh.G..LhHu...........h............p............s........s................h.............EY....s...D.os...sM..........G...........pu....t.......C......N.As.ph...........phGW..hss...............h.........tls..ssth..............u.hh.thtl.sst.....s....ts.hlhl............sh............................................................................hahthR.tt.s.........................D....h............................................................................s............................................................................................	0	70	174	179
+5377	PF05549	Allexi_40kDa		Allexivirus 40kDa protein	Moxon SJ	anon	Pfam-B_7591 (release 8.0)	Family	\N	21.20	21.20	21.20	22.10	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.85	0.70	-5.10	7	19	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	0	0	20	0	234.20	36	68.90	CHANGED	pRTFFSNhshAL-ATpsLLsaVPPsRYslPssoLPLDELYGQLHALHpNSLEWLTHIsHssDpllshLNshs..u......psssLuclRsslppLsphlppltss.pphphphppsssoc.hpphpsl-TpLptLHt+lc.hsps.spssss.Pssossssss.sstsscs.LPhYQAtHPTt.CRoYGollasGss.+IPMDIhGRPASTAL+LplplsssspsTpVsYclhDDGhLLLS--lcTtHKLpH..SDsLALLHp+CPNFIYKI+scsLC	........pRsFFoNhshALsuTpsLlsaVPPsRYslPssoLPLDELaG.LHALHpNoLEWLTHIspss-plls.hssh...s......pss.Lscl+stlpsLsphlpplpps.pp...phpspp.tspp.hcplpulcspLttlp..h+lp.hspp.sps.st.Psso.spssso.sststps.LPsapApHPothCRoYGollasGhsh+IPMDlhGR.sSTAL+Lplphp.sspsTpVpaclhDsGhLLhS-plpT.H+Lp+..uDsLuLLHp+CPNFlY+h+spsLC......	0	0	0	0
+5378	PF05550	Peptidase_C53		Pestivirus Npro endopeptidase C53	Studholme DJ, Finn RD	anon	Merops	Domain	Unique to pestiviruses, the N-terminal protein encoded by the bovine viral diarrhoea virus genome is a cysteine protease (Npro) responsible for  a self-cleavage that releases the N terminus of the core protein.  This unique protease is dispensable for viral replication, and its  coding region can be replaced by a ubiquitin gene directly fused in frame to the core. 	20.70	20.70	21.10	23.00	20.60	19.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.16	0.71	-4.79	11	688	2009-09-11 10:39:17	2003-04-07 12:59:11	6	19	89	0	1	634	0	153.70	75	17.82	CHANGED	MELlcFELLYKTuKQ+PlGVhEPVYDpsGcPLFGEhScIHPQSTLKLPHcRGcA-l.TsLKsLP+KGDCRSGNppGPVSGIYIKPGPVaYQDYpGPVYHRAPLELFsEoQhCEVTKRIGRVTGSDGKLYHlYVClDGCILLKpAoRspscVLKWl+NhLDCPLWVTSC	...........................................................MELhsNELLYKTYKQKPsGVEEPVYDpsGsPLFGE+.u.sIHPQSTLKLPHcRGct-VsTNLtSLP++GDCRSGNs+GPVSGIYlKPGPlFYQDYpGPVYHRAPLEhFcEus.MCEsTKRIGRVTGSDGKLYH..IYVClDGCIl.lK.As+s.p.clL+WlhNhLsCPLWVoSC....................	0	0	1	1
+5379	PF05551	zf-His_Me_endon	Naegl_SSU_RRNA; DUF1519;	Zinc-binding loop region of homing endonuclease	Moxon SJ, Coggill P	anon	Pfam-B_7681 (release 8.0)	Domain	This domain [1] is the short zinc-binding loops region of a number of much longer chain homing endonucleases. Such loops are probably stabilised by the zinc and may be viewed as small but separate domains. The common structural feature of these domains is that at least three zinc ligands lie very close to each other in the sequence and are not incorporated into regular secondary structural elements. The biological roles played by these small zinc-binding domains are presently unknown [2].	27.00	27.00	27.20	27.20	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.21	0.71	-4.17	11	70	2012-10-05 18:28:12	2003-04-07 12:59:11	6	2	41	18	21	82	4	122.00	30	40.93	CHANGED	sCah.psspsst.psGY.plsh+ss..................tGpphYsH+l.shhAsscs.......t.h..h.tt.....uhplSHLCtNutChsPsHLllEspslNppRpsCp...tpsp.h.tst.hhpsC.H.....pPpC..lhshtthscshp	..........................................................................Ch..tsth....psGa.+hphhsp......................ttsp.YhHpl.shhAssptt...........phh.hl.psch.........uhplSHLC.........pNu.....tChpPsHLhlEs+s.NccRppCp............t+...h..ps...th.hhtsC.....H........pspC..hlshhhhsp...........................................	0	12	17	20
+5380	PF05552	TM_helix	tm_helix; 	Conserved TM helix	Yeats C	anon	Yeats C	Family	This alignment represents a conserved transmembrane helix as well as some flanking sequence. It is often found in association with Pfam:PF00924.	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.33	0.72	-4.30	143	2106	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	1303	14	507	1422	120	52.30	28	24.15	CHANGED	tpslsshhspll....salP........plluAlllLllGhllucllpphl.......splLpphsh.Dptls	....................p.hss..sh.ll......sahs........NlluAllIlllGhllA+hlsshV.......s+lhtpt.pl.Dttl.......................................	0	135	297	397
+5381	PF05553	DUF761		Cotton fibre expressed protein	Moxon SJ	anon	Pfam-B_7657 (release 8.0)	Family	This family consists of several plant proteins of unknown function. Three of the sequences (from Gossypium hirsutum) in this family are described as cotton fibre expressed proteins [1]. The remaining sequences, found in Arabidopsis thaliana, are uncharacterised.	19.00	19.00	19.00	19.00	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.82	0.72	-4.59	85	622	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	28	0	391	568	2	34.10	34	13.27	CHANGED	sps-.lsp+AEcFIp+F+cph+.LQ+...........pShp........p..hpphls.+u	......pp-.lDp+A....-cFIp+Fpcp....h+.lQ+............Sh........t..............................	1	33	211	313
+5382	PF05554	Novirhabdo_Nv		Viral hemorrhagic septicemia virus non-virion protein	Moxon SJ	anon	Pfam-B_7684 (release 8.0)	Family	This family consists of several viral hemorrhagic septicemia virus non-virion (Nv) proteins. The NV protein is a nonstructural protein absent from mature virions although it is present in infected cells. The function of this protein is unknown [1].	25.00	25.00	228.90	228.80	20.30	17.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.54	0.71	-4.58	3	37	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	3	0	0	29	0	122.00	86	99.65	CHANGED	MTTQSAHSTTSFSPLVLREMITHRLTFDPSNYLNCDLDRSDISsTDFFETTLPRILcDLRASTRLPYLHVLDMRISLLERTHYMFRNVPSSPATTGRhSDPELlIISHAEMtlLTsGSESTS	MATQPALSTTSFSPLVLREMITHRLKFDPSNYLNCDLDRSDISThDFFETTLPRIL-DLRASTRLPYLHVLDMRISLLERTHYMFRNVPSSPATTGRLTDPGLlIISHAEVGlLTsGSGLTS.	0	0	0	0
+5383	PF05555	DUF762		Coxiella burnetii protein of unknown function (DUF762)	Moxon SJ	anon	Pfam-B_7710 (release 8.0)	Family	This family consists several of several uncharacterised proteins from the bacterium Coxiella burnetii. Coxiella burnetii is the causative agent of the Q fever disease.	25.00	25.00	202.60	202.40	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.65	0.70	-5.14	3	27	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	7	0	3	18	0	237.60	53	99.52	CHANGED	M..saFhh.PKIDaQ-+......oNSQss.EcTLQEWLRGA..NssEcAslFIuSspppphPIhu-pp.sSuusLPKLcIc-IcsSIKhVcNpFKKaGLKDEsIlNYIL+aGGINGYsSLGpssLcclsplpGsspcsEN+.........+pTYhV+uKscVpYIEpFcllpls.hDRNsIGcF..luEVK.sollSKsG-IIHsCKKVplts.sApLchFKs+FGsQLphVETI+++LhElLsSLYpRlsplFN........EspNccsRssKpRhPGhu	.........l.cIDhpph......psSpss.EcsLpEWLRGA..ss.EcAplFIsss.....PIhupp..sSuusL.KlcI.-hhssIh...s.FKh.GLKsE.IlNYILpaGGIsGYhoLGpsshcclshspGpspcsEN+.........+hoYhV+sKscVpYIEpFchhphs.hDRNpIGcF..lupVK.sollSKsG-I.HsCKKVplts.stpLp.F+p+FGsQLphVpph+h+LhElhsSLhpR....Fp........tthNctsRssppphPhhp.	0	3	3	3
+5384	PF05556	Calsarcin		Calcineurin-binding protein (Calsarcin)	Moxon SJ	anon	Pfam-B_7783 (release 8.0)	Family	This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation [1]. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin [2].	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.97	0.70	-5.17	14	220	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	47	0	93	173	0	230.20	35	93.44	CHANGED	Ms.tst..spp++ppustIhp-lst.stp-.t.......pLDLGKKlSlP+DlMLEELSLhsNRGS+hFKhRQ+RVEKFhaEs.......hsspspsphpphsss.ssp...............tph....ust...s.s...sst.ht.....sPpsluPG..usPhKtlP...............................................scKhppsslsKoYhSPW-cAhss-.-hltshtsphPtP.ttp.p.scYKSFNRsAhPFGGac+As+hhshphPc.hp.s...s..hssh.pslssRPSFNRTPhGWhspt....h............lshssEo--L	....................................s.pp+t.s.tlhh-lp................thsLGKKlSlP+DlMLEELSLhoNRGS+hFchRQ+Rs-KahaEs.............hpsps..h.s.....p..h......p..p.hs..ssp................................th......ut...t.......s.s.....ssss.tt..........sspshuPG..usshpthP...............................................scchppsslsKsYhSPWc..pAh.usc.phhtsht.ch.t....p.phscY+SFNRsAhPFGGhppusph..hp..hphPc........s...h.h.p.lstRPSFNRss.GWlsp............................................................................................................	0	4	15	40
+5385	PF05557	MAD		Mitotic checkpoint protein	Moxon SJ	anon	Pfam-B_7761 (release 8.0)	Family	This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated [1]. 	30.20	30.20	30.50	30.50	29.30	30.10	hmmbuild  -o /dev/null HMM SEED	722	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.47	0.70	-13.42	0.70	-6.44	5	348	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	251	6	232	343	4	476.80	20	85.32	CHANGED	DDlcssTTshhst.ts.SplRSths+FLussLcuot.sLusSss...............suuSLpKQsppShsppc.........cAEpI+oKupLIQlEpEltptELcHKRAplELE+cuossA-pYE+Esc+NpELps+lKsLcEpEsshcschpEspEct+th+pKl.........DtsopKLppEKpDptp-A+-sluslsuclSEhQhpA.st-splpsLEoEhp-L+EQLEppp++h.......sEu-cKlQuLpsttsppu-pss+IKcLEpcLpphEs-stlVKo.+pcLhplPcLE+ElppL+-ENc+L+oh+csstLLcEElp-Lco+LERtEch+-clssLELEpEKLpsELpSWcsLtQshsL..sLsTP-DlSp+lstLQpc-lpLsE+ssSlsSss+pLEsopQsLQcchppssupltEt+cKpEcp+shsRRLQ++lsLlTKERDthRAlLcSYDcEpT.ostSsph.p+L.csEDllQcVcsapuchEs...pL..c-sp--lulQKc+scsLcpElchL+pQhsss-p.h..spEtssu...LRh+l-oLEuEpuRLRpEpplLEMcht+hsLpGDYshucTKVLHhSpNPuucAcppp+sslE+LQAEs-+LKcll+tLEcsssps.sDsp.ssuSplouKElA-LKKQVESAEtKpQRLKEVFpsKIpEFRcACYpLhGY+ID.l........sssopYRLTShYAEcc-DsLlFcusuSosu.MpLLEosaStolschI-lalccpsSIPAFLSALTLELFsRpT	..............................................................................................................................................................................................................................................................................................................................................................................t............................................................................................................t..............................................................t......t............p...........t.................t..p...........tt....h.....................t...................ht.....t...............tt................................................................................................t...p..t.hpt..tt.....hlppp..t.ptp......ht......p.................th...t.php...h.tph..t.h........h.t....t........s............................s....s...............t...l................p.......h.............t...p.p.h.h.htp.st.hp........p.......htt.......hp....ptht...ph...t...p.h.........t....t.h.p.........p....................t......t............t......................p..t...........h..t...cl...ppph.lh.cEhchh.+....t...ltt..h...p.t......p....t........t.......t...................................tt....p.hpt...........t............................h.....p.h.....t.....h........p..t......t............t....t......tt.............t.t....................h..p.tplptp..........pthpp..pht........hp...p...l..t..p..............................t...........tph+lLp.hp.sPh...t.....t....p.php.LptE...tp.L.h..t.l.......t..........t..........t..........................t.h..............h......................................t....................h.....tph.c.tp...l..t...p...h...p....h+..pR......LK...pla...pt+..p-F+..csshtlh.........Gaplc.h...........hsp........s...p.h+lpSha.......................t.....p......p...p.............l...h....p..h.........t.....t...s................h.......................................t...h.........ht..l.t....t.phPshh.ush.shp.h......................................................................	0	80	130	193
+5386	PF05558	DREPP		DREPP plasma membrane polypeptide	Moxon SJ	anon	Pfam-B_7798 (release 8.0)	Family	This family contains several plant plasma membrane proteins termed DREPPs as they are developmentally regulated plasma membrane polypeptides [1].	23.20	23.20	27.30	25.70	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.45	0.70	-4.47	7	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	20	0	18	49	0	185.70	48	97.38	CHANGED	MuYWKoKVLPKIKKlF.-KsG.sKKAAAAEhpKoFD-uKEthsKEFE-KKsELQPKVlEIYEAussEIKsLVKE..c.uGlKKpostVpKFl-ELsKIEFPGuKAVSEAsuKhGPuhlSGPlhalhEKVSTFls...pEpK.cEts............sAspspsptps........tscEK-lVlE.EcKKEEtAsPs.........ts.ss...-.t.tcc.spsssAsA..sEP.Ks	.......MuYWKoKVLPKlKKlF.-Ksu.sKKA.AA.AEhhKoFDEuKEplsKEhEEKKTELpPKVVElYEAussElK.sLlK-..Ksuul.KKNSsuVpKFL-ELsKI-FPGuKsVSEAsuKhGsuhluGslhFlhEKVusFlP....cE.K..tcE...s..............sA.sptpptp.s................tspEKc.hsE..EtKccEtsss.s.................ttts.ss.s.s-tt.....tc...tt..tssss....stP.K...............	0	2	8	13
+5387	PF05559	DUF763		Protein of unknown function (DUF763)	Moxon SJ	anon	Pfam-B_7805 (release 8.0)	Family	This family consists of several uncharacterised bacterial and archaeal proteins of unknown function.	20.00	20.00	22.00	63.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.11	0.70	-5.48	30	177	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	170	0	106	193	49	316.90	44	82.83	CHANGED	GsA-LPLHsG+VP.WLhpRMp+LupsIs-lllcEYGscclLcRLucPhWFQuFusllGMDWcSSGoTTsshGsLKcsLs..sc-.lGlhVsGGKG+putpTPcELptlu-+hsLDu...ppLspsSRLsAKVDssslQDGapLYpHsFllo-cGcWuVlQQGMNscp+hARRYHWhust..psFsppPHsuIsG.hppstlLNlss+cuccsRcshl-LlpE.sPs+.lhpphpphhshhp............................h.h.tt+.lhtpslshchhtpsLptshEhsPpcFc-lLhlpGlGPpTlRALuLVAElIYGsPssapDPs.......+auaAhGGKDGhPaPV	................G.ADLPLHsG+VP.WLhpRMp+LuthIschllccYGtcclLcRLucPhWFQuFusVhGMDWcSSGhTTsshGALKcuLs...sp-lGlhVsGGKG+pSRpTPpELhtlu-phulDu...ppLspsSRLsAKVDssAlQDGapLYhHuFlloccGcWsVlQQGMNscp+hARRYHWhup......th.ps..FlppPHsuIsG..hppsp.ll...NLss+cuttsRps.l-Llp-.sPs+.lhpph.ppltsh.t.......................................................................thhhPsc+plhtp...s...lsh+c.lt..tsLtts.hEtsPpsFc-LLhl.GlGs+TlRALALVAEllaGsPspapDPs.............+FSaAhGGKDGhPaPV..........	0	43	68	83
+5388	PF05560	Bt_P21		Bacillus thuringiensis P21 molecular chaperone protein	Moxon SJ	anon	Pfam-B_7820 (release 8.0)	Family	This family contains several Bacillus thuringiensis P21 proteins. These proteins are thought to be molecular chaperones and have mosquitocidal properties [1,2].	25.00	25.00	367.20	367.10	23.80	17.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.22	0.71	-4.90	2	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	0	0	11	0	182.00	93	99.96	CHANGED	.sENtsFYKIFThcNNNhChNsTLLE+lFKNNl-EFDFSLVKpNLEHEKNCVITSTMNQTI.FENMNSpEMGpKsYSFhNQTVLNNKGNoSLEEQlSsIF.RCVYMpstKSSSYIK.LEQD.NplchhsSLlFIsPY+pNlh.IhPVsLpLTLlsKNVKpsS.pNlFSGDhHFNMVTMTaLT	MTENGVFYKIFTTENNNFCINPTLLERVFKNNLDEFDFSLVKKNLEHEKNCVITSTMNQTISFENMNSTEMGHKTYSFLNQTVLNNKGNSSLEEQVSNIFYRCVYMEVGKSSSYIKPLEQDSNKIRYVCSLLFIVPYKNNITSIIPVNLQLTLLSKNVKQSSSTNIFSGDIHFNMVTMTYLT	0	0	0	0
+5389	PF05561	DUF764		Borrelia burgdorferi protein of unknown function (DUF764)	Moxon SJ	anon	Pfam-B_7823 (release 8.0)	Family	This family consists of proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).	25.00	25.00	58.90	58.80	21.90	16.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.12	0.71	-4.85	2	127	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	28	0	12	99	0	175.50	65	97.09	CHANGED	MIlsLsp.lpaLI+IhpsFKhYh..pphEh-IlNTYNHPYLpKhsTsosNllsLK.-uhEtLhs+s.+sts.hcph.EFplpFplYhlshVL.pt.hDu.pphhhlYthh.-FLHpphaKaphppp.ps-.h.hlsaYlh.hSNhpssGLlslushauNhsaShs.hF...VtsIplLKpE+	...MIhTLDhlLNHLhpIFKGFKAYATENNFECDIINTYNHPYLSKITsuSSNIIALKFDGTEsLFDHNsRuGsFYENALEFSlNFQIYIIAIVLNApDFDANSRMLhLYuMLS-FLHN+.s.HKYTLtpp...QP-YlsKINFYIYPhSNMQTVGLINLGTKYSNHAYSASlAFNASVKsIEILKEE.h......	0	8	8	8
+5390	PF05562	WCOR413		Cold acclimation protein WCOR413	Moxon SJ	anon	Pfam-B_7803 (release 8.0)	Family	This family consists of several WCOR413-like plant cold acclimation proteins.	25.00	25.00	45.40	25.20	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.16	0.71	-4.76	15	123	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	37	0	50	124	0	164.80	42	87.45	CHANGED	LsMKo................stsussllsSDhcELssAA......+KLAsH...AlpL.....uuLGFGso...hLpWlAshAAlYLLlLDRTNW+TNhLTuLLVPYIFhoLPollFshlRG-lGpWIAFlAlllRLFFP++FP-a....LELPuuLILLlVVAPslhAsphRso..hlGssIsLsIuCYLLpEHI+uSGGF.+sAFs+usGVSNolGIllLh	.....................................................l.tchpthhhus......cphusp....shhh.....suh.shuss...hLpWlushAAlhLLllccstW+..TshhsuLLVPYlhhphPsslFshhRG-hGp..WlAFlAlllRLFFsppFPs.....LELPsu..hlLLllVAPphhssh.Rss..h..hGshlsLhIusYLl.pHlptuGGh.+puFspupslussluIhll....................	0	11	35	43
+5391	PF05563	SpvD	Sal_SpvD; 	Salmonella plasmid virulence protein SpvD	Moxon SJ	anon	Pfam-B_7864 (release 8.0)	Family	This family consists of several SpvD plasmid virulence proteins from different Salmonella species.	25.00	25.00	150.00	149.90	18.60	17.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.49	0.70	-4.83	3	25	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	15	0	1	12	0	202.20	98	100.00	CHANGED	MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYIHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD	MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD	0	0	0	1
+5392	PF05564	Auxin_repressed		Dormancy/auxin associated protein	Moxon SJ	anon	Pfam-B_7941 (release 8.0)	Family	This family contains several plant dormancy-associated and auxin-repressed proteins the function of which are poorly understood [1].	25.00	25.00	25.70	25.00	24.00	22.40	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.94	0.71	-3.50	21	211	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	59	188	1	110.90	35	91.34	CHANGED	LWDDlVAGPpP-p.GLGKLR.+hosps..lslpt.s-up................sus..hpRSlohss..................sPsoPsTP..oTPs..oP.ouR.p.-NVWRSVFpPGSN.uT+shGuphFDKPspPNSPTVYDWLYSs-TRS+HR	.......................................................LWDDsVAGPpP-p.GLGKLRKh.ohps.....shp...stut..........................tps.thp+Slsh.p........................sPsSPu.ss....ooPs........oP..h....o..sc....c.pps.....WRshh.pss..p..t.tpt.t.usph..pp.s...tPpoPTVYDWh..........................................................................	0	13	38	49
+5393	PF05565	Sipho_Gp157		Siphovirus Gp157	Moxon SJ	anon	Pfam-B_7948 (release 8.0)	Family	This family contains both viral and bacterial proteins which are related to the Gp157 protein of the Streptococcus thermophilus SFi bacteriophages. It is thought that bacteria possessing the gene coding for this protein have an increased resistance to the bacteriophage[1].	28.60	28.60	28.90	28.60	27.50	28.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.88	0.71	-4.66	29	450	2009-11-04 11:20:49	2003-04-07 12:59:11	6	1	390	0	49	359	53	153.40	29	97.10	CHANGED	hpLYELsspatplh.phhpp...hDs-tltDTL-u..lppsh-sKs-shsplI+sl.......-uDscslKtEtcRLt-++Kuh-sclcpLKsYLtptMptsshc+l+s..shholulpKstsuVpl..--stlPscYh.....ts.KlDKpsltc.....sLKsGcclsGApLcpsc.sLpIR	.....................................pLY-Lsspatpl.................p...........h-s...-..h....l....t..D..T.L-u.......lpsphcs....Ks-shsphl+sh.......puchc.hhcpEh+RLp....p....++.c...shpspscpLKsY.......LtptMpts......s..hc.....+l.cs....shhplsl.p.Ks.s..S..l...pl.....hD....E.........sh.l....Ptcah.........ppp.+hDKptltc.....sL.K.s.GpclsG.AcLhp.sc..sLhI+........................................	0	14	28	36
+5394	PF05566	Pox_vIL-18BP		Orthopoxvirus interleukin 18 binding protein	Moxon SJ	anon	Pfam-B_7955 (release 8.0)	Family	Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasises the importance of IL-18 in response to viral infections [1].	21.60	21.60	22.30	22.20	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.74	0.71	-4.12	2	55	2009-09-10 15:00:19	2003-04-07 12:59:11	7	1	18	1	0	49	0	123.30	86	99.62	CHANGED	MRILFLIAFMYGCVHsYVNAsEhKCPNLsIVTSSGEFhCoGCVcaMPpFSYMYWLAKDM+SDE.sKFIEHLG-GIKEDETlpThDGtIsTLpKVLHVTDTNKFspYRFTCVLTTlsGVSKKNIWLK	..MRILFLIAFMYGCVHSYVNAVETKCPNLDI...VTSSGEF+CSGCVEHMPcFSYMYWLAKDMKSDEDTKFIEHLGD.GIKEDETVRTpDGsIsTLpKVLHVTDTNKFAHYRFTCVLTTlDGVSKKNIWLK........	0	0	0	0
+5395	PF05567	Neisseria_PilC		Neisseria PilC beta-propeller domain	Moxon SJ, Bateman A	anon	Pfam-B_7966 (release 8.0)	Domain	This family consists of several PilC protein sequences from Neisseria gonorrhoeae and N. meningitidis. PilC is a phase-variable protein associated with pilus-mediated adherence of pathogenic Neisseria to target cells [1].\	 This domain has been shown to adopt a beta-propeller structure [2].	21.10	21.10	21.70	21.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.18	0.70	-5.40	9	608	2012-10-05 17:30:42	2003-04-07 12:59:11	6	13	415	2	192	644	232	326.40	25	29.43	CHANGED	LGDIVNSPIVAVGt.....YLA........................TSANDGMVHIFKps.GuDcRuYNLKLSYIPGTMPRKDIpN.....p-STLAKELRsFAEKGYVG..DRYGVDGGFVLR+l..-.stQcHhFMFGAMGhGGRGAYALDLoKhDuN.P..ssssLF.....DVKcs...spNGpNRVc..LGYTVGTPQIGKTHNGKYAAFLASGYAoKc.IsSssNKTALYVYDLEs.sGT..lI+KIEVPGGKG...GLSSPTLVDKDLDGTVDIAYAGDRGGNMYRFDL.....SsssPsp.........WSVRTIFcGT..KP.............ITSAPAlS+LKDKR..VVIFGTGSDLSEDD..Vsss-tQaIYGIFDsDT..GT..sospsGpGsGLLEQsL..spEsKTLFLoshK	...........................................................................................................................................hGDllpS.........h..hs..s.....................hhh...........................................suANDGMlHhF.................s.....s......s.............s.......t.....................p............p....t.hu.....al.......P..................................p...sl.ht....p.....L....t......t..h...s....p..t....s......a.......t...........cp..Y.hV....D.G...s........s..h..............t....c..s................th.s.s................s..........h+.....shlhGuhstG...............G....+.............u..............h..............aAL....DlT...........t...................s..s...........s...s.h...t...hh....................................p.h.p...s.s.................t....t.....s...s..p.......LG..oh.u...p.P...............l........s........+.............h.............p............s......G...........p...........a....s..........s.......l.h..GsG......Y..........s.........s.......t..s.............................................................s....p......s..........u..........L............al...l...c........h.................p............s.....................Gs..............h...........l........t......p....l.........s....s....s..s...u....ps................G.L.....u...s....s..........s...l..l.....D.......p.............s....s..D.G...h.s.....D......h.....s...Y.......A...G........D.......h.....t.......Gsl.......WRF.D.l...............ss...s...ss.ss.................................h.s...h........t.................h.....t...s.........pP........................................Io.st...P....l............h............s...t..h.................h.l.h.h.GT.....G....p.........h....t..t.tD..........h...s..p...t.p.....thYul...h..........D..t.tt......................................................................ht............................................................................................................	0	41	123	162
+5396	PF05568	ASFV_J13L		African swine fever virus J13L protein	Moxon SJ	anon	Pfam-B_7998 (release 8.0)	Family	This family consists of several African swine fever virus J13L proteins.	20.80	20.80	20.80	23.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.41	0.71	-4.76	2	103	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	12	0	1	95	2	169.90	80	100.57	CHANGED	MDSEFFQPVYPRHYGECLSssssPSFFSTHMYTILIAIVVLIIIIIVLIYLFSSRKKKAAAAIEEEDIQFINPYQDQQWutVTPQPGhuKPAGAoTuSAGKPVhsRPsTN.....+PsTN+PVhDp.sMAsGGPtAASAsA........aPAE.YTTsTTQNTASQTMsA.ENLRQRsTYTHKDLENSL	.............MDSEFFQPVYPRHYGECLSPVosPSFFSTHMYTILIAIVVLlIIIIVLIYLFSSRKKKAA.A.AIEEEDIQFINPYQDQQWAEVTPQPGTSKPAGATTuSs....GKPV.TGR......P.....ATNRPss.....s+PVT.....sN.....PV..........TDR.....LVMATGGPAA........AsAAA..................sAHPsEPYTTVTTQNTASQTMSAIENLRQRsTYTHKDLENSL...................	0	0	0	1
+5397	PF05569	Peptidase_M56		BlaR1 peptidase M56	Studholme DJ	anon	Merops	Domain	Production of beta-Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein       and a transcriptional repressor.  The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains.  The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription. Homologues to this peptidase domain, which corresponds to Merops family  M56, are also found in a number of other bacterial genome sequences.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.98	0.70	-5.45	12	1807	2012-10-03 04:41:15	2003-04-07 12:59:11	6	87	857	0	421	2510	322	241.60	19	47.77	CHANGED	hhlhthslssshslLllhllRhhl++hhushhsYtlWhlV.lthlhshh...............tsshthshspsPhstsssp.............shstsh.thshtslh.hL.hllWlsGsll.....htuhhhh+pp.hl+phs.hps....phLttstcpht...............sPhlhGhh+PpIllPssh..phsscEhchIlhHEhsHl+RtDhhhNhlsshhpslhWFNPllaluh+thchDpElACDtsVLst.ppcpR+pYucslLpshhusss..sshssph...sppsL+cRlhhl	.....................................................................................................................................................................h...........................................................................................................................................................................................................................................................................................................................................h.................h...h....h....h........l.W.....l.h...h...h.....h..h..h.....h..h...h..h...h....s..hh.......h...t..................h......h..t....................h...........t....................t..hh............t........h..................p...ht..........................h..........l...h.........s....t....t....l.....t...s...P.....h..h......h.......u....h......h......c....s....h....l.l..l.P....p.t.............ph.....s..p.p.c.l....c.hIlhHEh......sHh.+.p.+D........h.l.hhh..l.....h.t.l....h..t.....h.l.h........W.F..NPh...l..a.hhh...pphppspEhtsD.ctVl........p..p.........t........p....p.tt....p.Yupsll....p....h..s...h..t.t...s.h..........................h..h...s....t..................tpp.lKcRlh...............................................................................	0	214	340	394
+5398	PF05570	DUF765		Circovirus protein of unknown function (DUF765)	Moxon SJ	anon	Pfam-B_8063 (release 8.0)	Family	This family consists of several short (27-30aa) porcine and bovine circovirus ORF6 proteins of unknown function.	25.00	25.00	63.70	63.60	17.10	16.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.94	0.72	-7.27	0.72	-3.98	3	13	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	0	10	0	28.70	94	99.73	CHANGED	MASSTPASPAPSDILSSlPQSERPPGRWT	MASSTPASPAPSDILSRLPQSERPPGRWT	0	0	0	0
+5399	PF05571	DUF766		Protein of unknown function (DUF766)	Moxon SJ	anon	Pfam-B_8021 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	25.00	25.00	26.10	25.70	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.29	0.70	-5.13	5	128	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	91	0	77	117	0	262.90	52	91.77	CHANGED	ChGLYCGRTLLtsNSSp-h.....YS-CGACPRGpRoNsQphCsPCp-sLptYDWLYLGFMAMLPLllHhFFI-hstKs.pKpS+uplhpalSAllEsslAAllTlLlo-PlasL+IpSCcVphLSDWYThhYNPSPsYpTTV+CTQEAVYPLYTIVFVaYhFCLVhMhLLRPlLVsKI...LsVus+hK.ulYuALYFFPlLTlLHAVuGGLIYYuFPYIlLVlSLVuhAlHhSh.Kl-pohKsLl++.shp.++lllLhuHWLLLAYGllSL.ps.plcYDluLLs..LVPsPsLFYlFTlKFT-Pu	.....C.GhYCG+sh..L.pss...............au-CG...sCPRGpRs.....Ns.pphCpPCs-sPphYDWLYLGFMAhLPLlLHWF..F.I-h...........hs...tK..pSpssLhpHloAlhEsshAAllTLLls-PlGsLhlpSCcVhh...LSDWYThLYNP.SPcYhsTl........HCTpEAVYPLYTIVFla..YAFCL.V.hMhLlR.P..lLl.pKl........Ls.+ss+....hK....SIYAALYFaPILTllpAVuGGLlYYuFPYIllllSllohAla.hSh..clcp..shc.............Lltp.........Kpl.llLhuHWLLaAYGIlSls..............php..p..hp....c...hshLs..LVPhPuLFYlhTs+FT-Ps................................................................	0	27	32	56
+5400	PF05572	Peptidase_M43	Peptidase_M46; 	Pregnancy-associated plasma protein-A	Studholme DJ	anon	Merops	Family	Pregnancy-associated plasma protein A (PAPP-A) is a metallo-protease belonging to Merops family M43. It cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II.  Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary and the cardiovascular system.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.62	5	563	2012-10-03 04:41:15	2003-04-07 12:59:11	8	39	269	10	378	715	221	143.40	28	22.67	CHANGED	sspscsItsatW...DNpKYMNVaIQs-L.ssGuTsNSGsAWYPcoGMos-slARVsFNGtYLus...ssoSosFuuoLTHEFGHFLGLcHTFcGG....CccGsup......DcssDTPspsutch....usspslhN......CsG-hlNspNaMDYNs...CpsMFTQsQVsRMsssL-	................................................................................ttshth..............................................................................................................................................................................................................h.........h.....................h.......................h..........s.....h.....u.....p.....Ths..HElGHaLGLaHs...F..ps.s...............Cs.s......ht.......................Dh.l..sD.T...P.sp...s...p..s..p...s...........ss..s..t.s.h..ss...........................C..s..s...t......s....h............h.......p....NaMD..YosD.....sC.h.....s..p.F..TssQhsRMpt...t..........................................................	1	151	254	320
+5401	PF05573	NosL		NosL	Moxon SJ	anon	Pfam-B_8116 (release 8.0)	Family	NosL is one of the accessory proteins of the nos (nitrous oxide reductase) gene cluster. NosL is a monomeric protein of 18,540 MW that specifically and stoichiometrically binds Cu(I). The copper ion in NosL is ligated by a Cys residue, and one Met and one His are thought to serve as the other ligands. It is possible that NosL is a copper chaperone involved in metallo-centre assembly [1].	20.20	20.20	20.20	20.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.84	0.71	-4.50	50	701	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	544	2	243	576	51	139.30	25	73.14	CHANGED	hhhLuuCscppss..t.s.sshplsspspC+hCGMhls-aPGPKuQlhhput..ps....haFsss+Dhauahh.....pPEps.+plpAlaVpDMup..ssWppPss....ppaIDAc......pAaYVhGSsppGuMG.splssFuscssAptFAsca.GGpVlpFc-Is.shl	........................................................................h...h.uCt.tttt.......s.htl.p.p.p.s.hC.t.hCsMsl..h..-..hs..t.tuplh..h....pss....cs...........hhFss.ht.shhtahh......................s..c....p.........s......c....p...h.ptlaV.pDhss..............................tpaI-Ac..........cAhYV..hsos.....h.h...u....s....M...G..shlsFusc.p.sAcpFspp...p....G...G+......lls.ac-ls......................................	0	66	185	221
+5403	PF05575	V_cholerae_RfbT		Vibrio cholerae RfbT protein	Moxon SJ	anon	Pfam-B_8029 (release 8.0)	Family	This family consists of several RfbT proteins from Vibrio cholerae. It has been found that genetic alteration of the rfbT gene is responsible for serotype conversion of Vibrio cholerae O1 [1] and determines the difference between the Ogawa and Inaba serotypes, in that the presence of rfbT is sufficient for Inaba-to-Ogawa serotype conversion [2].	27.90	27.90	27.90	28.00	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.81	0.70	-5.35	2	55	2012-10-10 17:06:42	2003-04-07 12:59:11	6	1	34	0	2	97	69	238.30	95	99.24	CHANGED	MKHLIKNYVQKLIKTELDAIQSKSVHDNRNFIYNGEFLILESEFGhHCFPRVQLNHALSYKNPNFDLGMRHWIVNHCKHDTTYIDIGANVGTFCGIAARHITQGKIIAIEPLTEMENSIRMNVQLNNPLVEFHHFGCAIGENEGENIFEVYEFDNRVSSLYFpKNTDIADKVKNSQVLVRKLSSLDISPTNSVVIKIDAEGAEIEILNQIYEFTEKHNGIEYYICFEFAMGHIQRSNRTFDEIFNIINSKFGSKAYFIHPLSSAEHPEFNKATQDINGNICFKYVS	..................................................MKHLIKNYVQKLIKTELDAIQSKSVHDNRNFIYNGEFLILE...SEFGWHC.FPRVQLN.HALSYKNPNFDLGMRHW.....IVNHCKHDT..TYIDIGANVGTFC.GIAA.R.HI.T.Q.G.KIIAIEPLTEMENSIRMNVQLN..N..P.LVEFHHFGCAIGENEGENIF....EV.....YE...FDNR......VS...SL.YFQK.NTDIA.....DKV...K.N.S.QV.LV..R..KL.SSL..D..I.......S..P..TNS..V..VIKIDAEGAEIEILNQIYEFTEKHNGIEYYICFE....F...AMGHIQRSNRTFDEIFNIINSKFGSKAYFIHPLSSAEHPEFNKA.TQDINGNICFKYVS...................................................................	0	2	2	2
+5404	PF05576	Peptidase_S37		PS-10 peptidase S37	Studholme DJ	anon	Merops	Family	These serine proteases have been found in Streptomyces species.	19.50	19.50	19.50	19.50	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.67	0.70	-6.03	2	98	2012-10-03 11:45:05	2003-04-07 12:59:11	6	1	87	0	31	179	5	421.20	41	91.66	CHANGED	AEPKAVDIKDRLLSIPGMSLIEEKPYTGYRFFVLNYsQPVDHRHPSKGTFQQRITVLHKDVNRPTVFYTGGYNVSTNPSRREPTQIVDGNQVSMEYRYFTPSRPAPADWSKLDIWQAASDQHRIFKALKPLYS+NWISTGGSKGGMTATYYERFYPRDMDGVVAYVAPNDVVNKEDSAYDRFFARVGTDECRDKLNGVQREALVRRAPLEKKYAAYAAENGYTFDTIGSLDRAYEAVVLDYVWGFWQYSTLADCADIPADAKNATDDAIWGSVDAISGFSAYTDQGLETYTPYYYQAGTQLGAPTIHFPHIEKKYIRYGYQPPRNFVPRSIPMKFEPWAMRDVDTWVRHNARHMLFVYGENDPWGAERFRLGHGARDSYVLTAPGMNHGANVAGLVPDQKARATARILDWAGVAPAKVQENPSAARPLATFDARLDQRDVEREPALRP	................................................................sst......Dlpc+L.ulPGhohlc.c...h...........s..uY.R.h...aVlpa.sQPlDH...+....+....P...p.p.GoFpQR.....l...hl....h...H..........+.....s....h....s....R...P...T....V..hh.TpG.....Y.s......s....u.......h.....s...P..p....h...p........E........o.pL.....l.......s.....uN.p.....lslEYRaFs.SpP......p....P....t......D.........W....s.....h.......L...o...lh.....QuAsD......H...+..lh.p.A.h..K....p....l.Y....s...t....+.........W...luTGhSKGG.TuhaYRpFaPcDlDsoVsY.V.AP...s.h.h.s.t.EDu..ta....-.t.F.h.......p.p....VG.T............t......-..............CR...c+l..pshQ..h..EsLhR+ss.......Lls+a.cp..ausppshTFc.hlGsl-cuaEhsVL-YsFuFWQau.s.s.s.Cs.s...IPu..tsAoDcpLasalssISuh.s.hasD...p...uhtsYssaaYQAuspLGh.shch.sa.h.cth..l....c....h....Gh.p.......sR.a.l......Pcpl..s..M.c.....F-.shhpclcpWl+csup+MlFlYGpNDPWoApshphhc.G..t+.spa.VastPGusHs.AplusLsts.p+tpAhutltcW....................................................t.........................................................................................................................................	0	13	22	29
+5405	PF05577	Peptidase_S28		Serine carboxypeptidase S28	Studholme DJ	anon	Merops	Family	These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.45	0.70	-5.91	12	1264	2012-10-03 11:45:05	2003-04-07 12:59:11	7	20	253	9	917	1384	70	339.30	23	80.92	CHANGED	QpLDpFcsssscoapQRYahNspahpss..uPlFLhl...GGEushssthltss..thhphApcaGAhVh.LEHRFYGpShPhsshost.sl+a...LoSpQALtDlApFIpshs..phphtsss.WIsFGGSYuGsLuAWhRthaPcLlhGulASSuPlhAplDFh...EYhpVVtsSlpphus....p.ChsslppuFsplcpLhtospGppsl..ppthphssshspt...s-.pDht.hatslhu.atulVQYs..hDspss.shs.hslpphCphhh......ss......oss..s....hshhh.l.pphstt...shshtpsshsh.hhss...phpssu.....hts.sRtWhaQTCoEaGaaQosss....stthFusshPsshal.chChslFGsshspp.lptslttTN.h..YGG..p.suoNVlhsNGslDPWHsLG..htssssuollshlIpusuHCsDMhsspsuDsspLpsuRphl	...................................................................................hDp..........s....................p.............tpa.....p...RY.h.h..s..t..p..a.a...p...............s............u.......P.l......hhhh..........usE...s.........s...h...t.........h....h.......t..ps..........hhh.p......hAt.....phtuhhlh...h..EH.................RaY...G....pS...h......P...........h............s..........s............s......h......t.....p..........lpa...................LospQA...............L..sDhs..hh....p...............t........h..........p.........t................p.......h..............................t..............t......s.....s..............hlhhGG...............SYuGh..............Lu...AWh...........Rhp........YPc..l..hh.................uulAo.Sus..l..............t......h.......h.......s..h...........ta...h.p..lt...psh....s...................p..C.ttl.ptsh.....p..l..p.p.h.h........t..p...........t..t................ttl...........tp.ht.....h..s..........h..p................p.........................h..................................t..h..h.......pa.............................................................ht.........h..Ct..h..........................t....................................................................h.......h............h.........................................t.............................................t.......................s....ttW..aQ.sC.s.E..h....s....h..........s..s...ss...................t...h...h...s..p....h..s.....h...p....h..h....p.C..............ph....a.............s........................................................t.....h....s..............a.G.u..............................t......s...s....p...lh....a...ss...............G..hDPW.....p........h.........u..........h..........p........t........................s.................p...............s..........h......h..h......t..s.............s.Hp....Dh.......................................................................................................................................................................................................................................	0	328	536	770
+5406	PF05578	Peptidase_S31		Pestivirus NS3 polyprotein peptidase S31	Studholme DJ	anon	Merops	Family	These serine peptidases are involved in processing of the flavivirus polyprotein.	20.50	20.50	22.60	25.00	20.40	18.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.32	0.70	-5.13	4	226	2012-10-02 13:45:52	2003-04-07 12:59:11	7	34	30	0	0	244	0	175.10	90	7.31	CHANGED	GPAVCKKITpHEKCHVNIhDKLTAFFGlMPRGTTPRAPVRFPTuLLKVRRGLETGWAYTHQGGISSVDHVTsGKDLLVCDSMGRTRVVCQSNNKhTDETEYGVKTDSGCP-GARCYVLNPEAVNISGoKGAhVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNE-SKPTKLMSGIQTVSKNpADLTEMVK	..GPAVCKKITEHEKCHlsIhDKLTAFFGlMPRGTTPRAPVRFPTuLLKlRRGLETGWAYTHQGGISSVDHVTsGKDLLVCDSMGRTRVVCQSNNKhTDEoEYGVKTDSGCP-GARCYVhNPEAVNISGoKGAhVHLQKTGGEFTCVTASGTPAFFDLKNLKGWSGLPIFEASSGRVVGRVKVGKNE-SKPTKlMSGIQTVSKspsDLT-MVK......	0	0	0	0
+5407	PF05579	Peptidase_S32		Equine arteritis virus serine endopeptidase S32	Studholme DJ	anon	Merops	Family	Serine peptidases involved in processing nidovirus polyprotein.	24.70	24.70	24.70	25.10	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.86	0.70	-5.44	6	275	2012-10-02 13:45:52	2003-04-07 12:59:11	8	13	15	6	0	344	2	299.70	70	11.60	CHANGED	LThlWVpFF.....LlsVshhAGVsulslLlshWhLuRhTslsGlVTPYDlHhlTuoPRGu.....uulAoAP-GTYLAAVRRuALTGRsthFlPoshGSVLEGuhRT+psutNsVsVhGSohGSGGVFTIsGpsVVVTAoHVLu.sspARVossGasppLsFKssGDYAhAcs..ssWpGsAPplchu.pshpGRAYWpssoGlE.GllGpssAFCFTsCGDSGSPVlsEDGpLlGVHTGSNKpGSGhVTTPsGcTluhuslKLSEhupHauGPtVPlusl+LPcplIsDVcuVPSDLsuLl-SlPslEG	.................................................................................LTILWLVFF.....LISVNhPSGILAlVL...LVSLWLLGRYTNlAGLVTPYDIHHYTSGPRGV.....AALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSLLEGAFRTpKPSLNTVNVVGSSMGSGGVFTI.DGKlKCVTA.AHVLT.GNSARVSGVGFN...QM.LDFDV..KGDFA.IADC..PNWQGsAPKsQFCpDGWTGRAYWLTSSG........V......EPGVI.........GsGFAF.C.F.TACGDSGSPVITEAGELVGVH.TGSNKQGGGIVTRPSGQFCNVcPIKLSELSEFFAGPKVPLGDVKIGSHIIKDssEVPSDLCALLAAKPELEG........................	0	0	0	0
+5408	PF05580	Peptidase_S55		SpoIVB peptidase S55	Studholme DJ	anon	Merops	Family	The protein SpoIVB plays a key role in signalling in the final sigma-K checkpoint of Bacillus subtilis. 	21.70	21.70	21.90	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.18	0.70	-4.89	6	510	2012-10-02 13:45:52	2003-04-07 12:59:11	7	3	487	0	114	438	11	195.60	43	45.24	CHANGED	hpc.Ku-upY+IGLWVRDSsAGIGTLTFY-PpoKKYGALGHsIoDsDTp+llslcsGpIlcSolsSIcKGspGsPGEl+GhFss-pcsIGslppNophGIFGshppc......hsNhpspsl.Vuhps-VK.GPAcILTsIDscplcpaDIEIVphs.QcuPssKuMVIKlTDs+LLccTGGIVQGMSGSPIIQNsKllGAVTHVFVNcPssGYGlaIEWMLc-	...............................t...tptpY+lGLalRDssuGlGThTFhcspstpaGALGHsIoD..D.Tt.p.l.lpsGplhposlhuIc+GppGpPGEhhu.h.a....p.p.p.h.lGsIptNo.hGIaGphppt............t...h......pcsh.lAhpppl+pG.s.A.p.I.l.Tslcs.p.clcpF-IEIhplh.pptsusKuMl.I.+lTDtcLLpcTG..GIVQGMSGSPI.lQ.sGKllGAVTH..V..F.V.N.D..PspGYG..la..IEhMLp......................	0	64	95	101
+5409	PF05581	MCP_N	Peptidase_S38; 	Vibrio chemotaxis protein N terminus	Studholme DJ	anon	Merops	Domain	This domain is found at the N terminus of several methyl-accepting chemotaxis proteins from Vibrio species.	21.40	21.40	22.10	21.80	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.26	0.72	-3.87	2	277	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	155	2	39	173	3	101.50	42	16.53	CHANGED	M+FSpKIVAASSsLLLsslALLShpQh.pVR-EIcShVpDSl.EhVcGVppThtpslsu+KulAQ.sTpllp.sPp..s.s+ollppP.lKsoFLhlGhGhEp	...MKFSHKIVsASShLLLsTlALLShpQhhplRsEIcshVpsSlpEhlcGVpsTlps.lsu+KuLAppsTpllphcPs..shlcsllppPhlKsoFLhlGhGhEp........	0	8	13	28
+5410	PF05582	Peptidase_U57		YabG peptidase U57	Studholme DJ	anon	Merops	Family	YabG is a protease involved in the proteolysis and maturation of SpoIVA and YrbA proteins, conserved with the cortex and/or coat assembly by Bacillus subtilis.	25.00	25.00	26.50	26.50	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.91	0.70	-5.44	25	309	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	285	0	73	206	2	268.90	49	98.65	CHANGED	hclGDlVsRKSYspDIhF+II-Icp.tpstchslL+GlchRLlADAPhcDL.hlcpschpc..pc+phppchpcsl+plhpctp............hhcpcpphpsssshppptphFphPG+VLHlDGDs-YLchCLclYcpLulsshGhtlpE+-QPcclhsLlcca+PDIlVlTGHDAhh...KsctshpDLssYRsS+YFlcoV+pAR.+apPshDpLVIFAGACQSpaEullcAGANFASSPsRVhIHALDPValsEKIAaTsls-sVslp-llcNTITGtKGlGGlETRGKhRhGhPhp.h	.............h+lGDlVsR+SaspDIhF+Il-Ict.........clAILpG.clRLlADAPh-DLhtlcpcchpcpt+p..cpphpcsh+hhppchh..............h.c..pcp.ph...p....s..st..s..hp..pp..paFphPG+VLHlDGDstYLcpCLclYpclGlss.GlpspEpE.scclhcLlcca+PDILVlTGHDuhh...Ks..c..t..shtDLsuYRpS+aFVpuV+psR.+h.PshDpLVIFAGACQSaaEALlcAGANFASSPuRl.IHALDPValstKIuaTsh.-hVslhDVlcNTITGtKGlGGlETRGhhRpGhPhp............................	0	31	58	64
+5412	PF05584	Sulfolobus_pRN		Sulfolobus plasmid regulatory protein	Moxon SJ	anon	Pfam-B_8140 (release 8.0)	Family	This family consists of several plasmid regulatory proteins from the extreme thermophilic and acidophilic archaea Sulfolobus.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.16	0.72	-4.01	6	48	2012-10-04 14:01:12	2003-04-07 12:59:11	6	5	28	0	10	65	3	69.50	40	58.43	CHANGED	hEKLTlophILlpLSt+.CtTLEcLpE+TussKphLLVhLTRhaK+GIIhRKWp+aGG+KaREYCLKhREEll	.....................p+Lp.pptI.LlhLu+t...CtTLE-LcctTsls+spLLVhLo+Lt+cGlItRcWt+.h..u.G+KaR.c.YCLK..h...................	1	2	3	10
+5413	PF05585	DUF1758	Peptidase_A16; 	Putative peptidase (DUF1758)	Studholme DJ	anon	Merops	Family	This is a family of nematode proteins of unknown function. However, it seems likely that these proteins act as aspartic peptidases.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.87	0.71	-4.69	3	313	2012-10-02 15:32:34	2003-04-07 12:59:11	7	33	35	0	292	363	0	145.90	19	16.24	CHANGED	VsVpNApGs..hTuCRLLFDSGSELSYISERCINsLGLARTPSRILVoGISusKA-sTRGsoplsIpSRlSssT.LsVpAHVLuKITSSLERpsIDsSlLsVFNDLphADopF..uolAPIDILLGSDYlWusITGpKI+DstGsLIAISSIFGWVITSltus+usoAT	.......................................................h..............htsLhDsGSphoalopp.htpt..LtL....t..t..pp....h...h.t.hh..u...t...p....p..s..p.t.tt.htph...p...l.p....h.p..h.p...s...t.t........hp....l...pshs..ls..p.....l.....s.s.pl........hsl....s..t..p.......h..p..th..t..slpl.s.-....th..ppt..tp..hDlLlGs...Dhh.hpll.ttp.h..hpt...tst.hhh.pohhGal.ls.............ssh...........................................	1	167	170	284
+5414	PF05586	Ant_C		Anthrax receptor C-terminus region	Yeats C	anon	Yeats C	Family	This region is found in the putatively cytoplasmic C-terminus of the anthrax receptor.	25.00	25.00	30.00	30.00	21.90	19.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.36	0.72	-3.53	10	141	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	37	0	79	109	0	91.80	65	19.15	CHANGED	VRWG-KGSTEEGARLEKAKNAVVpMP-EEhE.P...cPsP+ssPs+pPs.pcKWYTPIKGRLDALWALLRRQYDRVSlMRPpsGD+G..RCINFoRVps	..................VRWG-KGSTEEGA+LEKAKNAVVKhP-pEhE.P..p..sps.p.s.p+pPs.ppKWYTPIK.G+LDALWALLRRtYDRVSLMRPQsGDcG..R.CINFsR..............	0	2	10	38
+5415	PF05587	Anth_Ig		Anthrax receptor extracellular domain	Yeats C	anon	Yeats C	Domain	This region is found in the putatively extracellular N-terminal half of the anthrax receptor. It is  probably part of the Ig superfamily and most closely related to Pfam:PF01833 (personal obs: C Yeats).	25.00	25.00	25.40	36.80	22.90	20.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.33	0.72	-4.18	12	190	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	39	22	100	145	0	102.50	51	22.00	CHANGED	lp+SChEILulcPSSVCss.........EsFpVVl+GsGFppu+p.ppVlCoFphNpohohsE+Ps.slcssalLCPAPhLpcsGpshplpVShNsGhSFISoulpITuopCosG	........................c+SChEILusEPSSlCsG.........EsFQVVl+GNGFppu+ss-pVLCoFplN-ohT.l..s.cKPh.sVccsalLCPA.P..lLccsGpp..hslpVShNsGhSFISSSlhITsTcCosG.....................	0	7	16	45
+5416	PF05588	Botulinum_HA-17	botulinum_HA-17; 	Clostridium botulinum HA-17 protein	Moxon SJ	anon	Pfam-B_8286 (release 8.0)	Family	This family consists of several Clostridium botulinum hemagglutinin (HA) subcomponents. Clostridium botulinum type D strain 4947 produces two different sizes of progenitor toxins (M and L) as intact forms without proteolytic processing. The M toxin is composed of neurotoxin (NT) and nontoxic-nonhemagglutinin (NTNHA), whereas the L toxin is composed of the M toxin and hemagglutinin (HA) subcomponents (HA-70, HA-17, and HA-33) [1].	20.80	20.80	21.10	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.97	0.71	-4.31	3	33	2012-10-02 19:42:32	2003-04-07 12:59:11	6	2	16	1	2	40	0	128.20	72	92.70	CHANGED	MSAERTFLPNGNYKIKSIFSsSLYLTPlSGuLTFSNTSStNNQKWKLEYluEsNuFKISNVAEPNKYLoYNsaGFIsL....DSoSNcsYWhPIKIAlNTYIIsoLscVN.hDYAWDIYDsNsNIoDQPLLLLPNFDIpNSNQMFKLEKI	..............................MSsERTFLPNGNYpI.KSlFSs.S..L..Y..L..s.sSGuLoF.SNpSShsNQKWplEYhupspsF+hS..NVAEPNKYLuYss...aG...F.I.L.....sS.SN..pshW.PIK.IAlNoYIhhoLshVN..hDYAWsIYDsNpNIhsQPlL.LPNFDI.NSNQhhKLEKl......................................	1	1	2	2
+5417	PF05589	DUF768		Protein of unknown function (DUF768)	Moxon SJ	anon	Pfam-B_8463 (release 8.0)	Family	This family consists of several uncharacterised hypothetical proteins from Rhizobium loti.	21.00	21.00	21.40	21.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.98	0.72	-4.04	7	32	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	12	0	19	32	1	62.80	33	72.41	CHANGED	MSTRGIsFLccWIucplP-TstuD.llSls-LTpKLhADAKAhGItpp-I-E-suSlaphIlcAl	...MSp+u.pFLcpWIu-pl.sss.spsD..h....l....uhs-.LscchhADActtGIspp-.I.pE-s..GslhchIhpu................	0	0	13	13
+5418	PF05590	DUF769		Xylella fastidiosa protein of unknown function (DUF769)	Moxon SJ	anon	Pfam-B_8396 (release 8.0)	Family	This family consists of several uncharacterised hypothetical proteins of unknown function from Xylella fastidiosa, the organism that causes Pierce's disease in plants.	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  --amino -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.86	0.70	-5.18	6	104	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	12	0	12	77	0	212.10	35	45.08	CHANGED	PPIDSRTGKP.MMAGPWENRDLSLEYFQLDFLGQYTVKHAFINGINIDRCYPGAPPDHVQVVMMoh+sGScoPGIlsphpG+.PPpPhspoAAFIGhcKSNTosch.PcG.oVLRp.Ds.....VsthhKFssLCoAcFsGGN-..IpFGIR........SAsSpSIpuhlpstssLspAs.+......-hhusR.................sFlc.sPcTETRWGNsWTWa.+AalPoPl...GDGlEhWM.TPIGsoGYYlsVphNFhEutRQKNTEsYQRA.........RcLMDGlLQSVVIQKp	.........................................................................................................................................................................p............G.pslpp.............phs.hspA.hsGGsp..l.aGhc........suhu.ultttlpsh.thhpts........thhspp.......................................hlc.ssppEpRassshohh.+t..ss.sl...G.sGlE...hhh.TPlGs.uG..hosshphh-utt.pssc.hphA.........ppLhsGl..p.lhpK....................	0	0	11	12
+5419	PF05591	DUF770		Protein of unknown function (DUF770)	Moxon SJ	anon	Pfam-B_8473 (release 8.0)	Family	This family consists of several proteins of unknown function from various bacterial species.	20.70	20.70	21.00	21.00	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.99	0.71	-4.67	91	1558	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	971	0	276	902	48	153.90	37	85.07	CHANGED	hh..scs.tsRVpIpY-lcssuupcclELPhshhVlGDhoG....tpspsslc-R+hlslD+-NFcsVMcphsPplshpVsNpL..ss....s....splsVcLsFcShcDFsP-slAcQVstL+cLLEhRptLssLpu.hsspsshcchlpclLpssshhcpLtsEhp.ht	..................h.hucs.tsRlpIpY-lcssGupcclEL..Phshh..VlGDhuu.........tp-p.......sslp-...R.....chlsID+.cNFssVMpphsPplsas.V....sN.s.....Lt....ss.....s..............splsVsLsFcShcDFsP-slA+p..Vs.pLppLLEhRptLssLps.hsspsshcph.....lpplLpssphhppLhpcht.hh...............................	0	50	118	197
+5420	PF05592	Bac_rhamnosid	bac_rhamnosid;	Bacterial alpha-L-rhamnosidase	Moxon SJ	anon	Pfam-B_8527 (release 8.0)	Family	This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria [1].	35.60	35.60	35.70	36.10	35.30	35.40	hmmbuild  -o /dev/null HMM SEED	509	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.52	0.70	-6.29	25	1344	2012-10-03 02:33:51	2003-04-07 12:59:11	6	54	458	3	498	1369	219	462.90	20	56.56	CHANGED	lpcsssuphllDhGQNhsGalRlc.VcuspGsplpL+auEhLc............cGslt..TpsL.........RsAcsoDpYIh...........pGc.tt-........papPpFTa+GFRYVclsGh..sp.....hsss..s..........lsuhVlaSD...hccsGsFcsScshlNpLacNshWohRu.NFhulPTDCPQRDERlGWTGDspshu.sAsahaDspshhs+WLpDltssQps.s.................G....shPslsPssh.......ssssssssWusuhlllPWslYppYGDppllccpYsuMctal-alppcsss......hh.thssaphGDWL............sssspTstsll.AoAaascssphhuchAphlGpsp.....D.AccYpshuccl+pAFpscal.sssG..............plsssT.....QTAhsLsLhasLV..........Pcstp.ttssppLschlcpsst+lsTGFl..GTshLhpsLsc..sGcp-lAYclLhpcshPSWhY.lsp.GATTlWEpW-uhh.......tsstMsSaNHYu.hGulspWhapsluGlp.............sstPGa+clhlpPtPs.usLs.A........cusacosYG.cIcscWchc..sGp.hpLplplPsNosApVhL	................................................................................................................h......t.hlh.DhGpphsGhhph...p.....h.........p.....s..........t...u.......t......t......lp.hh..h....uE.....ht.......................................................t..u.p..h...........t.h........................................................h...h.h.......................t.Gt.....t...........................h....st....h..s..h...h.u....FR..Yl..p..lpsh...tt...................t...p..................lpu..h.hhhs.s............ht.....t..u..p..F.p..s..u.s..........hl.N........plap.shhs.......hp...........s.shh.....s..h.....sDC..PpR.ER..hsWhGDhth.s...s.sh.h....h..s..s..t..t..h...hpchlps.h.ts...tp....p.........s...............................G..........hh...s...t....h....h...Pt................................t.s....ssa.....s...........h...h......lhhsap...h.Yhhh.G..Dp....p...hl......pp....h.as.s...h..p...p....hl.....ca.hhp.ptss....................................h.ssh....t.h.u...DWh.................................sht.tt..s..s.t..th.....h....s..ss.h.h.h.hshph..hsph....A..p....hl.G..c.pt...................................c..sppapp...ht.p...p.l.pp...s...h...pp..p.....a..h.s..ppu.............................................tht.s......s.o............psu.......sh....ul.hh.sl.h..........................s.p.p....tt.......t.....t..h..hp......tL............h.p.h..........h........t.......t.........p............s..........h.....t......h.........s......s..G......h.h..............u.......s...al....h......p....s....L.........sp..............tGt......t....ch..s..........hph...h.......h........p....p........hss.....Wh..h.l...p......p......G....A...T...ThW.Et..a..ss..............................s.h.sShsHhh.hu..ussta.hhphlhGlp...............stpsGa.c.phhlpPt.............sslp.s...................puph.....o....s..h....G..t....lp.sp.Wph..........p.......s.........st.....h.php..lplP...s..spu.l..............................................................................................	0	220	361	461
+5421	PF05593	RHS_repeat		RHS Repeat	Yeats C	anon	Yeats C	Repeat	RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding (e.g. [1]). Note that this model may not find all the repeats in a protein and that it covers  two RHS repeats.	20.80	20.00	20.80	20.00	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.35	0.72	-3.69	203	21340	2009-01-15 18:05:59	2003-04-07 12:59:11	9	591	1319	0	3320	21290	603	38.60	28	15.02	CHANGED	YD.spGpLhs......hs.t.......ssGpss..p.ap.YD.stGp...ls....ph.....ssssGp..s	..............................................YD.ttGpLsp..........................hT..s..........................ssGpps.........p.Yp.YD..stGp...........ls............ph.........psstG...............................................	0	1007	1995	2696
+5422	PF05594	Fil_haemagg	haemagg_repeats; 	Haemagluttinin repeat	Yeats C	anon	Yeats C	Repeat	This highly divergent repeat occurs in number of proteins implicated in cell aggregation [1]. The Pfam alignment probably contains three such repeats (personal obs: C Yeats). These are likely to have a beta-helical structure.	21.50	2.30	21.50	3.30	21.40	-999999.99	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.60	0.72	-3.64	157	6916	2012-10-02 14:50:22	2003-04-07 12:59:11	9	294	419	0	1577	9015	69	75.00	16	36.58	CHANGED	sssGphplpss.............................................................ht.spsutlssssslslp..usshhs.ssush.stss......................................hplsusGsLsspu	.................................................................................................................................................................................................................................h..s.spsG.....t..l.t.u.s...s.s..l.sls......u.s.sl.s...s..s....G...t..l.....u..s..s...s..h..t..h..p..s..tt...ttt....................................................htlts.t.sth......................................................................................................................................	0	229	664	1231
+5423	PF05595	DUF771		Domain of unknown function (DUF771) 	Finn RD	anon	Pfam-B_7023 (release 8.0)	Family	Family of uncharacterised ORFs found in  Bacteriophage and Lactococcus lactis. 	22.90	22.90	23.40	23.40	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-10.12	0.72	-4.07	18	367	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	341	0	27	185	0	87.50	33	84.35	CHANGED	-stlllscpphp-lpptshcs.h....hsls-lp++h.s.+upshlpcpllpsP+FcKplchp....GhlhaPp.spus+.ahhps+chpcal-cpFpEIh	.........................................shllls+pEYpEL.hthshcshW...........hshs-Lc++l..p..tS.cphlpcplLhcP+acKclchp.....GhVhYPs..psts+...WpFpA++hpcFl--aFsEI.......................	0	8	18	22
+5424	PF05596	Taeniidae_ag		Taeniidae antigen	Moxon SJ	anon	Pfam-B_8569 (release 8.0)	Family	This family consists of several antigen proteins from Taenia and Echinococcus (tapeworm) species.	20.80	20.80	21.70	25.90	19.60	18.60	hmmbuild  --amino -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.99	0.72	-4.16	11	312	2009-09-11 08:34:58	2003-04-07 12:59:11	6	1	13	0	0	302	0	60.60	39	80.77	CHANGED	--sc.sccsspslhKtluEl+c.FFpcDPLGp+lspLsK-hpphspthRpKlRpuLtEYl+sLhsE	..................csp..ppstpslhKtluEl+c.FFcpDPLGp+lspLs+-lstlspcl+tKlRtsLpcYl+sLhpE....	1	0	0	0
+5425	PF05597	Phasin		Poly(hydroxyalcanoate) granule associated protein (phasin)	Moxon SJ	anon	Pfam-B_8339 (release 8.0)	Family	Polyhydroxyalkanoates (PHAs) are storage polyesters synthesised by various bacteria as intracellular carbon and energy reserve material. PHAs are accumulated as water-insoluble inclusions within the cells. This family consists of the phasins PhaF and PhaI which act as a transcriptional regulator of PHA biosynthesis genes. PhaF has been proposed to repress expression of the phaC1 gene and the phaIF operon [1].	41.00	41.00	41.00	41.00	40.90	40.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.54	0.71	-4.39	31	264	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	196	0	80	242	32	129.00	33	71.12	CHANGED	cKpsps.......pphsspl+cpAcQIWLAGLGAauKsppEGu+lF-sLV+-Gcplc++s+phs-cplsssp.......ppht....phssslps+AsspWD....+LEphF-cRVspALsRLGlPopc-lcALpp+lDpLstplccl.sppp	...........................hpppspphhtclcchu+pIWLAGLGAa...........u+.......s....ppE.......Gu...........+.......h.......F-sLVKcGEphEccspptssc..plspsp.......pphp.......sp.hsps+spstsphs....+lEpsFDcRVspuLsRLGlPo...+p-lcsLpp+l-pLptpl-plstt.t.....................	0	19	45	65
+5426	PF05598	DUF772		Transposase domain (DUF772)	Moxon SJ, Bateman A	anon	Pfam-B_8195 (release 8.0)	Domain	This presumed domain is found at the N-terminus of many proteins found in transposons.	22.60	22.60	22.60	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.29	0.72	-4.08	160	5949	2009-01-15 18:05:59	2003-04-07 12:59:11	6	34	1706	0	1322	5334	675	71.70	25	21.55	CHANGED	GRP.shssphhl+llllphhh.sl.Sscpltctlpcshtaphh.sG......p.........tsPDtoTls..cFR.pthtppt.......hhcplhpplh	....................................GRs.uhs.t.hhl+ll....llth.hh.ul.Sscplpctlpp.slt..h..phF.st....ht..p..........thPc.hoT.ls..caR..pthtppt..........hhpplh..................................................................................	0	433	891	1052
+5427	PF05599	Deltaretro_Tax		Deltaretrovirus Tax protein	Nicot S, Moxon SJ, Studholme DJ	anon	Pfam-B_8606 (release 8.0)	Family	This family consists of Rex/Tax proteins from human and simian T-cell leukaemia viruses. The exact function of these proteins is unknown. Tax is the viral transactivator; is it a nuclear phosphoprotein that interacts with CREB, coactivator CBP/p300 and PCAF to form a multiprotein complex, which activates viral LTR and stimulates virus expression. Tax is also involved in deregulated expression of numerous cellular genes leading to T-cell leukaemia. Rex is a nucleolar post transcriptional regulator that facilitates export to the cytoplasm of viral RNA not or incompletely spliced [personal communication, Dr. S Nicot].	25.00	25.00	26.40	26.30	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-9.95	0.72	-3.68	2	33	2009-12-01 13:32:35	2003-04-07 12:59:11	6	2	8	0	0	27	0	57.10	74	73.91	CHANGED	M.hhSPLsRhhTEsshhIPSLRVWRLCopRLVs+hhhshFtPPssupPotHLstAssHLGPHRWTRhRLSSslPYPSsPLLPHPENL	......................hhIPpLRVWRLCTtRLVPHLWGTMFuPPTSSRPTGHLSRASDHLGPHRWTphRLuSTl............................	0	0	0	0
+5428	PF05600	DUF773		Protein of unknown function (DUF773)	Moxon SJ	anon	Pfam-B_8595 (release 8.0)	Family	This family contains several eukaryotic sequences which are thought to be CDK5 activator-binding proteins, however, the function of this family is unknown.	20.40	20.40	20.40	20.70	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.67	0.70	-5.72	14	218	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	140	0	135	217	5	387.50	32	91.65	CHANGED	Mp-h.sLPIDIpouKLLDWLVDRRHCshcWQppVhsIRcKIssAlpDMP.Ep-cIhpLLuGuaIsYFHChcIl-ILKsTEusTKNlFGRYSSQRMKDWQEIlphYEKDNlYLAEsAplLlRNVsYEIPuLRKQlsKspQhtpEhpR+ct-hppsAAph+ccYhpsCKphGlpGpNl+pELlsll.pDLPuhhpclutss.us.LpcAl-hYpAFssasp.......p.sstplLPlLpaltc+G.NoTlYEa+pupsPhsVEcP..chp.........phs.-......sss--p....IDW..GD......t.s....ss.u..phtstpIDaGhsh-ss.s..........-........thsGIDWG..............D..upssshpIsl.-sGos.......t...uVA+GpDAhoLLEsspsRspFlDELhELcuFLsQRLsEhp..--ssllshothphuPsllttpTscplpsMLu-VcsllspLoshphQHLFhIpuSPRYV-Rls-pLcQKh+ptchLttptpths-KppEAtpppscLcP+l-hlhppTR-LQK.IEuDISKRYssRPVNLMG	..........................................lsI.DItht+L.-WLlsR+hsshpWpt.lhtl+t+IptAht..s.......hP..pt.pt.........h.......hp.hL.......p..s............s.I....pYhc....s.h.cIl.-lLpto.-.t.s..o+.slFG.pau.up.hhc..-W....ppIl.thYEK-shaLsEhuphlhcsVsYEIPul+KQltKhp...Q..p-hp++pt-hptsttphtppahtt..Ccph..Gl.p.................G........p..s......l.+tEL.hths.ppLPs.h...t.clhtth...tp.............ltpulchYpshst.hh.....................t...ttt...h..Ls.hL..phl.pps....s.shh..p.hpt.tt.t..s....hpps..t.h..........................t...............t.tpst.......IDa..Gs...........s......t.s...t......s..tlDhu......t.t..............................t.stI.sas..............................................t...ph.sh.pts.................t...th.u.p...u...p....th...plL-.sphRsphls-LhELc.FL.......t..Rh.Eh....p...pp...........s...................s.lthp..t.t..s..l...s..........pph.thls.lpthls.lss.phppLh.lhtS.+al-plsp.Lppphpt.thhh.tht.h.t+t.ch..pp.tt.tsphphhhtpo+pLpp...........hEtplSph.aps.R.VplhG.....................................................................................................................................................................................	1	55	77	110
+5430	PF05602	CLPTM1		Cleft lip and palate transmembrane protein 1 (CLPTM1)	Moxon SJ	anon	Pfam-B_8636 (release 8.0)	Family	This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family [1]. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis [2].	19.70	19.70	20.30	19.70	19.10	19.60	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.54	0.70	-5.77	26	492	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	253	0	331	471	12	368.50	30	71.07	CHANGED	tusltuhlpslhhhhshhhhhs.Fhs......sssssssssts....t.............................htshatpsp.lsltlYsSssshhsshts.s...Llhpccshshush.sp.........shslslPcp...l.ppNGoLahHhhls.psGh.h.st....satstphh.ahsts...LspYh.p+.hp+p+NLLuspc-p...p-pcpcts.............ssphhuaa+PNlTlsllsDpsshshsslPPsltpahplpssssp........YhPllalNpFW.L+cchh.lNpTs..ppLsLplshpsluhaKaphhsph-puhppttph.........Gtsts-..h.-plKchLLDT...N.YLLulThlVolLHhlFEaLAFKNDIpFW+p+.KshhGlSlRollhNsFhQhlIFLYLhDN..cTSaMILsspGhGlllEhWKlsKslclclph...........uhlPh........ltFpD+.t.hopsEp+Tc-YDplAh+YLhhlhhPLlsuYAlYSLlY	...................................................................................................................t.......h..hhhh.h.h...hht.hh.................................................................................................shh.t.t.............h..pl...l.aho.......p.t......tt..........................hhhp...ps.h.hssh..pt.....................thphp...hspp..................h..ppN.G..ol.ah...+haht...hsG................apt..thh....hh.t..........lsp....Yh.....p...tcphsLLsspppt............p...t...ppt...............................sp.hoaa+PplolsllsDths..hshs..plPss..ltp.ahp.h.th.stp......................................YhPllahspahp....htcchh...........l......Npos........ppLs.Lplshps.................luhh+aphh.h..p...hpp.sh.........tp.h.................................................................G...s.....tp-......h.DplKthhl-T...N.YLLulThhV.......ohlH...lF-h.LAFKN............DIpFWpp+.cs.h..GlSs+olhhpsa.phllhLYlhDp..pTshhlhhs.slGhhIEh.......WKlpKshplplp.............................uhhPh.....................hth.pt................o..........EppT.............cpYDp............hAh+YL.shlhhPLhhuhAlYSLlY..............................................	2	122	178	264
+5431	PF05603	DUF775		Protein of unknown function (DUF775)	Moxon SJ	anon	Pfam-B_8676 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	20.70	20.70	20.90	24.20	20.50	19.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.46	0.71	-4.80	35	312	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	278	0	220	310	3	192.20	30	94.21	CHANGED	MFGslsuG+sspssspplss......spalhslsss...........pshsalslFl..................Lssssh.PsshuAuVYaph.P......................tsssaphLGslsssKPSAIFKlst................................hsssps..............psts.lplGISlEPhspltpphsthppspss...................................sstplAp+IlpshaNaLuSFsss..................spshVPhpshccWacKFpp+lppD..PsFL	.....................................................hFGslhsG+.s....o...shptlsp.........spalhs...lssh...........pshsHlsVFl..................L.s..s..s..sh..Psshuuu.VYhph..P..............................ssssa..phLG..hlsspKPSAIFKlst....................................ttsts............................tsssssplGISlEshpslttphsshpst.st...........................................shpphAp+llpNhaNahuSFsss..................sspthVPhpshppWap.pFppRlpps..PsFh...............................	1	73	120	179
+5432	PF05604	DUF776		Protein of unknown function (DUF776)	Moxon SJ	anon	Pfam-B_8747 (release 8.0)	Family	This family consists of several highly related mouse and human proteins of unknown function.	25.00	25.00	30.00	28.90	22.60	23.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.31	0.71	-4.06	4	60	2009-09-14 12:10:08	2003-04-07 12:59:11	6	2	38	0	33	51	0	171.40	52	62.78	CHANGED	MEutuKDGEEEoLQoAFKKLRVDAEushsshps.cu.usRsusRouh-..ssKPK.hsS.K-oWHusoRKoSRGsVRTQRRRRSKSPlLHPPKFTaCSstA.PSs.....upLKH+..o.sEPsDstuscGpus....pusssSTALssssacsahhpPhtpss.cssppossc-tAspst........sutsu.sAsc.S	...............McSEAKDGEEESLQTAFKKLRVDAuGSlASLSVG.EGsulRAsVRoAsD..-sKPKssCuSKDSWHGSoRKoSRGAVRTQRRRRSKSPVLHPPKFhHCSThA.sS.s.....uQL.KHK......opsDssD.uuouhGhss.......sus...psS.suLss.sapthsh-Phtsolschsspsppcpt.u.sss.........sSpsoLtssp........................................................	0	1	3	12
+5433	PF05605	zf-Di19	Di19;	Drought induced 19 protein (Di19), zinc-binding	Moxon SJ	anon	Pfam-B_8581 (release 8.0)	Domain	This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought [1]. This domain is a zinc-binding domain.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.33	0.72	-3.84	56	760	2012-10-03 11:22:52	2003-04-07 12:59:11	7	63	135	0	411	688	2	57.80	32	13.39	CHANGED	spFsCPaCt.c.c.aDlssLCsHl--EHsh-u+.s.slCPlC.....u.......s.......+.......Vu..p..Dhlu......Hl...ThpHu	......tasCPY..Csc.t.hc.h.s.u.LtcHlppcHp.......p......s.sp.....s...s.......s...CP..lC........u.............t.............p.......hs..s..shhp......HlshcH..........................	0	82	147	264
+5434	PF05606	DUF777		Borrelia burgdorferi protein of unknown function (DUF777)	Moxon SJ	anon	Pfam-B_8755 (release 8.0)	Family	This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete).	25.00	25.00	31.70	31.60	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.03	0.71	-5.10	3	129	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	27	0	9	109	0	173.30	65	98.02	CHANGED	MocsYcIYRMNQRLYGHALAQEDlKNWIYSNIFIsRIGTVKEFKQQTQEAIVTIPEFEDLEIHTKNISNINLELSKGDsVLLLQSSINIFDKNDDIHFDKHHFYILSAISPKTLNLIsDTVKI+ANNpIEIANQoTSLKcILDsIISAINGIcIpGsusIDtoSL+......usTopINScINSLFK	.........ppDYcIYRMNQRLYGpALuQEDlKNWIYSNIFIh+IGTVKEFKpQTQEAIVTIPEFEDLEIHTKNISNISLELSKGDsVLLLQSSlNIFDKNsDIHFDKHHFYILSAISPKTLNLISDTVKI+AN...........N.pIEIANQoTSLKpI..........LcsIVSAIsGIcl.....hG....ss....s...I-.sSL+......IATopINSsINSLFK...............	0	5	5	5
+5436	PF05608	DUF778		Protein of unknown function (DUF778)	Moxon SJ	anon	Pfam-B_8777 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	22.70	22.70	24.10	23.70	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.79	0.71	-4.23	28	251	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	151	0	153	239	6	122.70	44	60.30	CHANGED	lPllSWLhPaIGHhGICsSsGl.IhDFuGsYaV................................................................u...............hDshs..FGsP.................................................s+YapL...................................................................................ctpph..s.....................sspsaDsAlppusccF.pp+saNlhs.......sNCHSaVAtsLNth........................................................pa.......psptsWshlplshhlhlpG+a	.....................................................................................................................................lPlloWhhPhIGHhG.ICsSsGV.IhDFAGsYaV................................................................S...............p.DshA.FGpP.................................................s+Yh.pL........................................................................................................................................................................c.p....ps...............................sspsWDsAlppuscca.pp+.......haNLhs............sNCHSaVAhsLNhh........................................................pY.......tssssWNhlpLshhhhltG+a..............................................................................................................................................................................................................................................................................................................................................	0	65	91	127
+5437	PF05609	LAP1C		Lamina-associated polypeptide 1C (LAP1C)	Moxon SJ	anon	Pfam-B_8782 (release 8.0)	Family	This family contains rat LAP1C proteins and several uncharacterised highly related sequences from both mice and humans. LAP1s (lamina-associated polypeptide 1s) are type 2 integral membrane proteins with a single membrane-spanning region of the inner nuclear membrane [1]. LAP1s bind to both A- and B-type lamins and have a putative role in the membrane attachment and assembly of the nuclear lamina [2].	19.70	19.70	21.60	20.20	19.40	19.10	hmmbuild  -o /dev/null HMM SEED	465	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.51	0.70	-5.82	3	144	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	46	0	66	138	0	318.60	39	82.94	CHANGED	MKTRRoTRL.pQHSQQsslQsSPApouRGLRDApuLS+D+pEDEsSSQP-oSQTlSKKTVRSP-EAsVSEDPls+LpRPPLR.PR.-ATpVQpKssF.EEGET.EDDp-SSaSsVTpl+lRSRDScESuDKsuRAuuHas-ShWuLP+SpuDFTAH-pQPSlLoTGsQKsPQEWssQAuRhRTRMtpcsILKSEhGNQSPSTS+pQsssQPss-Sh..VK+KtWW.......LLlLVAALASGlaWFFSTPs...VETTAVQEFQNQMsQLcsKYQGQDEKLWKRGpTFLEKHLNSSpPRoQPAILLLTAARDAcEsLKCLSEQIADAYSSFRSVRAIRIDGAGKAsQDSDTVKLEVDQELSsGF+NGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASLGLKElEEKVRDFLKVKFTNSDTPNSYNHMDPDKLNGLWSRISHLVLPVQPENALKcGuCL	....................................................................................................................................................................................................................................................................................................................................t.........................................................................................t..................................................................................................................ts.........h.............h.h.hh..h..l.h..t....a..h........s............spt.s.tlpt..............F........sphppLpppa.uQst.LWpRu.hhLp+H.LpsspP.spPAhllhTAup..cuccs.L+CLupplAs.......AYo.o.........pp.sp..s...l.p.IDGss.+shtDSDhVKh.lD.cLosGFcsGppAAVV.H+FEpLPsGSTLIFYKYCDHENAAFKDVALlLTVLL.E.E.c.s.Ltsslu.pEhEE+VRDhLhsKFosSssssSascMDsDKLsGLWSRISHLVLPVts.ptlctt.C................................................................	0	16	20	30
+5438	PF05610	DUF779		Protein of unknown function (DUF779)	Moxon SJ	anon	Pfam-B_8830 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	25.00	25.00	31.00	30.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.14	0.72	-3.97	40	460	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	440	0	184	402	460	96.70	60	72.22	CHANGED	pLIccLpucHG.sLMFHQSGGCCDGSuPMCYPpGEFhlGspDVLLGcI.................sGs.....PFYlSpsQFEYW+HTpLlIDVVsGRG.uhFSLEuPcGhRFLoRSRl	...LlcpLpscHG.PlMFHQSGGCCDGSu.PMCYPpG-FhVGcsDVhLGpl...................................sGsPhalStsQ..a-hW...KHTpLlIDV...VP...GRG...G...hFSLEsPcGlRFLoRSRl..........	0	51	127	159
+5439	PF05611	DUF780		Caenorhabditis elegans protein of unknown function (DUF780)	Moxon SJ	anon	Pfam-B_8886 (release 8.0)	Family	This family consists of several short C. elegans proteins of unknown function.	25.00	25.00	29.90	29.10	21.80	17.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.61	0.72	-3.26	3	44	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	6	0	44	25	0	68.00	71	70.29	CHANGED	MADKSAYMGAGGYGSGYMGSNASSSGYAREDYAQGGNGGSsNQQQQGSGGNTNPGGQVFKARTDQSCYLGP	.....MuDKSAYMSAGGYSSGYMGSNASSSGYAREDYAoG.G.S.GG..u...s..sss.sp..GSG...Gs.sN.sGuQVFKARTDQSCYLGP............................	0	10	27	44
+5440	PF05612	DUF781		Mouse protein of unknown function (DUF781)	Moxon SJ	anon	Pfam-B_8891 (release 8.0)	Family	This family consists of uncharacterised mouse proteins of unknown function.	25.00	25.00	41.60	40.30	19.70	23.50	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.18	0.70	-5.76	6	79	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	41	0	56	78	3	311.80	39	96.99	CHANGED	MuslhohshlLlhsh.ussAhsop..ps.P..WccuPtpLSch.hpssshhlNPWVap-RMshY+ILlNuTshYhupaGs-NppNsLWGLPLQhuWQh+SGRLsDPT..t.osCG.EhsDshCISssSWWuslNYYLSlIPFLAAVcpGllususcQVpI.sPscssp+FCosYSDCssthP-sMs+WcpFFQhLhplpt..pusaucpDplLpahWsAHtpSLspuopuFsD+hsaYScsElpFppuWsphVDalAAspFsTohspohpFhpsLPPRlLpssD.psP.IsDFTspQNpsLlhlthlNcl..Npllhs.hlpLh+phhpochsR-hhpt.l..hh..P....oohlcllpchhss....ss	.........................................hlhh.h..s...ths..sts.......-hhPPLWcpsPuphuDa.lcs....sthlIsPWsY.-..Rhu.hYKIL.lspTspYFspFuspNppNlLWGLPLQaGWQacT...GRLADPo..ptTsCGh-sGDphCISlcS.WWAs.hNYaLSslPFLAAV-oGlhGhuscpVplLP.Psc...sppcFCaslosCpouaPcsMs+WssFaQ........hl.........................p.s........t..s.shD.sL....L+ahWsAHsuoLp.....suhphFp-.R..hpa...YScsEssFscsWshsV-alAAspFsTsl.pohc.FQpu.LPsRhLhssD.hsPhIsDFoshQNtVLhhLphlppl...sp..hhG....h...............................................h............................	0	9	14	23
+5441	PF05613	Herpes_U15		Human herpesvirus U15 protein	Moxon SJ	anon	Pfam-B_8900 (release 8.0)	Family	\N	25.00	25.00	210.50	210.50	19.00	17.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.55	0.72	-3.71	2	6	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	8	0	109.30	77	80.20	CHANGED	M-sW+RQRLQEhRELCPL.lLMoLSNhhSKlEhlYlKYLFpMDFsThYRaIhsuLTLohTVTKSlVIEhLFIlKRWp-IcQhFpLsl+KspDCaIVAQFsHIPlKRhlhh	MDVWKRQRLQECRELCPLPlLMSLSNIlSKlEIIYVKYLFKMDFsTMYRFILPALTLSMTVTKSVVIEMLFILKRWEEIcQFFRLNIRKVNDCalVAQFTHIPVKRhllh.	0	0	0	0
+5442	PF05614	DUF782		Circovirus protein of unknown function (DUF782)	Moxon SJ	anon	Pfam-B_8909 (release 8.0)	Family	This family consists of porcine and bovine circovirus proteins of unknown function.	25.00	25.00	231.10	231.00	19.10	16.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.55	0.72	-3.86	2	77	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	75	0	104.00	95	100.00	CHANGED	MVTIPPLVSRWFPVCGFRVCKISSPFAFsTPRWPHNDVYItLPITLLHFPAHFQKFSQPAEISDKRYRVLLCNGHQTPALpQGTHSuRQVTPLSLRSRSSTFpp	MVTIPPLVSRWFPVCGFRVCKISSPFAFTTPRWPHNDVYIuLPITLLHFPAHFQKFSQPAEISDKRYRVLLCNGHQTPALQQGTHSSRQVTPLSLRSRSSTFpQ.	0	0	0	0
+5443	PF05615	THOC7	DUF783; 	Tho complex subunit 7	Moxon SJ	anon	Pfam-B_8919 (release 8.0)	Family	The Tho complex is involved in transcription elongation and mRNA export from the nucleus.	27.70	27.70	27.80	28.80	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.63	0.71	-3.91	24	286	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	245	0	202	276	0	141.00	28	49.99	CHANGED	-plh+.pRLlh.......s--+.hpplh+phhphtp.sst...................................cssptttpplhtphsth-hshh+hphhhp.sscpEpcpYpp.pcclcpslp....sh+pp.......htpL+ppLtcA+chhcp+p....caDpLuctIssps...sRpEppc...pLp	..................................-plh+.pRLLh.......s--+.hpplhKp.hhph.ss.ss...p.................................................ccttphhpchhtphuphEhuht+t..phl.hs.hNt+EhEpYpphppcI..psplp........ts+cc...........ItchKppLppA+ph+pp+p........................EYDsLAchIsppP.....sRp-ptppl............................................................	0	64	104	157
+5444	PF05616	Neisseria_TspB		Neisseria meningitidis TspB protein	Moxon SJ	anon	Pfam-B_8925 (release 8.0)	Family	This family consists of several Neisseria meningitidis TspB virulence factor proteins.	19.90	19.90	20.40	19.90	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	502	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.62	0.70	-6.13	3	184	2009-09-11 07:48:12	2003-04-07 12:59:11	8	4	72	0	16	177	2	264.20	41	79.54	CHANGED	ah.pF...ApPl+ISDsh.s.stptu+VpKFRPcuS+Fap...........S+lTEAuslEHIPTGAKA..RINAKITASVSRAGVLSGVGKLVRQGAKFGTRAVPYVGTALLAHDVYETFKEDIQARGYQYDPETDKFVKGYEYSNCLWYEDERRINRTYGCYGVDSSIMRLMSDYSRFPEVKELMESQMERLARPYWEhlRc..NRsDSh.F+NYNFsRCYFsWNGGsCsVuKG.DDuRoFISFSLtRNPKYKEEMDAKKLEEILSLKVDANPDKYIcATGYPGYSEKVEVAPGTKVNMGPVTDRNGNPVQVVATFGRDSQGNTTVDVQVIPRPDLTPGSAEAPcAQPLPEVSPAENPANNPsPcENPGTRPNPEPDPDLNPDANPDTDGQPGTpPDSPAVPDRPNGRHRKERKEGEDGGLLCDaFP-ILACsEMGEPS-NsFEDIuIPpsTs-cTWSscNhFPSSGVCPpPKTFHVF....GRQFusSYEPLCTlAE+lRFAVLluFIIMSAFlsFGSLu+E	..................................................................................................................................................huGsGKLsR.GAKh..uTRAVPYVGTALLAaDlYpTFKEDIpspGhpYDsETDKFsK.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................Cs.....................hpat.hC.h...ht.hlhh...h...h..............................................................................................................	1	5	10	11
+5445	PF05617	Prolamin_like	DUF784;	Prolamin-like	Moxon SJ, Bateman A	anon	Pfam-B_8935 (release 8.0)	Domain	Both DUF784 and DUF1278 members are found to be expressed in the plant embryo sac and are regulated by the Myb98 transcription factor. Computational analysis has revealed that they are homologous to the plant prolamin superfamily (Protease inhibitor-seed storage-LTP family, Pfam:PF00234) [1]. In contrast to the typical prolamin members that have eight conserved Cys residues forming four pairs of disulfide bonds, both DUF784 and DUF1278 domains only contain six conserved Cys residues that may form three pairs of disulfide bonds. These two domains may have potential functions in lipid transfer or protection during plant embryo sac development and reproduction [2].  This family has been merged with the DUF1278 family.	20.60	20.00	20.70	20.10	20.30	19.50	hmmbuild  --amino -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.35	0.72	-3.85	75	362	2012-10-01 19:46:35	2003-04-07 12:59:11	6	3	20	0	247	334	0	67.40	25	51.37	CHANGED	cChs.shhp.......hpsCss-Ihtshh...uc........tplussCC.pslhphscpCast.....hh.s..phshhss............lhshCs	................................hhsshhp.......sttCsh-Ihtslh...sp........sslussCC.pslhphscsCasp.......hh.s..thPhhhs..................lhshCs................	0	90	128	152
+5446	PF05618	Zn_protease	DUF785;	Putative ATP-dependant zinc protease	Moxon SJ	anon	Pfam-B_8936 (release 8.0)	Family	Proteins in this family are annotated as being ATP-dependant zinc proteases.	21.80	21.80	22.30	22.30	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.67	0.71	-4.49	11	1019	2012-10-02 15:32:34	2003-04-07 12:59:11	6	4	489	2	289	840	428	135.10	33	62.74	CHANGED	lhG...plhL.....p.htA+hDTGAhTuSLpAsslhsap+-GppWV+F.....hhspcsppuhshEh.h.t...l+ttts............ptR.VlclhltlGsplhptEhoL.........p-RpthpaPhLlG.RuhhthhuhVDPup+alps+p	...................................................llG.hEhltlsslshs....hcA+lDTGApTSSLpA.......hc.......Ic........Fc...+.s.G..p.......p.........W.V+F......................hp.p..s.s.......p.p.s.p....h......hE..t........l...hchtc.I.+sSsuc...........sppRhVlchplp..lG.s.tph.p..hEhTL.........sDRspMsa.lLLG.RphhcsthlVDsuppalt..............................	0	70	152	236
+5447	PF05619	DUF787		Borrelia burgdorferi protein of unknown function (DUF787)	Moxon SJ	anon	Pfam-B_9013 (release 8.0)	Family	This family consists of several hypothetical proteins of unknown function from Borrelia burgdorferi (Lyme disease spirochete). 	25.00	25.00	63.60	63.50	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.20	0.70	-5.79	2	137	2009-09-10 23:38:07	2003-04-07 12:59:11	6	2	27	0	11	119	0	334.20	72	97.88	CHANGED	MPpDTISVSLhpsRl.ssp.NYYNPLLlYKo.......sshs.hhLsLoVsNaEc.lcpLEhppGptpDp.tK...EcpL..LppAMusFF..up-uLKSsshalY.sp.cElKcaLKsphHsFVVhlNpttDs.......hpsDa-th+ps..FhVhSTK-pplhplhKsKspoEhcp.IAlYSsNc.NLHLKFhu.YLHQASIFHAVNPYGM.LsuTPlhDDolIspLRpupINFYSLLNETG.DGh.AFKEuVsLuGsSIDEhFThaYIKNEuIhELIRIWNKNsRtNSKLSALpLsGuhsNtYTuulEChh+chhpRGLIl.YKplplplsso.tLpLpLpVslpYN.ShNuVsLlITsQ-Is	....MPQDTISVSLlDSRIQAS+PNYYNPLLVYKTAKIKVNKDuAsaKhLsLTVNNYEKpIETLEK-NGNGpDQFGK...EKTL..LKTAMSsFFNSoEESLKSAsLFIYKDK..P..EELKpYLKsHRHoFVVLINTp.GDs..S..D..DGLplYKDDYsKFKtsSsFFVFSTKEQEIKELFK.DKuNoEK-RNIAVYSNN+DNLHLKFIStYLHQASIFHAVNPYGMsLuA.oPLl.DDTlIsKLRsAKINFYSLLNETGLDGlsAFKEGVDLuGsuIDEtFTYHYIKNEAIlELIRIWNKNNRQNSKLSALQLSGARDNAYTSAIECLLKRFlDRGLIlpYKsLpLTLSsTsQLKLELSVNITYNFSINuVuLVITTQDIV.......	0	6	6	6
+5448	PF05620	DUF788		Protein of unknown function (DUF788)	Moxon SJ	anon	Pfam-B_9014 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	20.70	20.70	20.70	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.14	0.71	-4.40	30	317	2009-09-15 15:32:55	2003-04-07 12:59:11	6	4	279	0	218	302	2	158.30	25	90.41	CHANGED	MAspusKKpAppNpphLptlphhhlshsslallh..hhhhspss..shhs.......hhlhshsthhshatLcphu+Ppas.........tpupLlcsG.DLpttG.h..hEYhhDllYlohhsplhshl..osKhWal.aLllPsauhYKlhs.hl..........hs.hhutssttttpt.............pspSKRQpKhE+Rtp+	..........................................................AscutKphhppNpptLphhhhhhlsssslahll...hhhhsp..ho.h.shhh.......hhhhshshhhs.hh.hhpphu+Ppas..................psGp...Lhc.....uG..DLs.htG....l.........sEahhDllhlThhsplhshh..oshhWhh.aLllPsauhY.hlas.hh......................htsh.hstsst.ttt................ttppK+pp+hc++.................................................	0	76	119	180
+5449	PF05621	TniB		Bacterial TniB protein	Moxon SJ	anon	Pfam-B_9028 (release 8.0)	Family	This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein [1] which is involved in Tn5053 mercury resistance transposition [2].	20.10	20.10	20.10	20.10	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.89	0.70	-5.66	2	273	2012-10-05 12:31:08	2003-04-07 12:59:11	6	5	203	0	59	418	28	254.90	42	95.42	CHANGED	MDEYPlIDLSHLLPAAQGLARLPADERIQRlRADRWIGYPRAVEALNRLEsLYAWPNKQRMPNLLLVGPTNNGKSMIVEKFRRsHPsuoDADQEHIPVLVVQMPSEPSVIRFYVALLAAMGAPLRPRPRLsEMEQLALALLRhVGVRMLVIDELHNVLAGNSVNRREFLNLLRFLGNELRIPLVGVGTR-AYLAIRSDDQLENRFEPMhLPsWEAN-DCCSLLASFAASLPLRRPSPIATLDMARYLLTRSEGTIGELAHLLhAAAlsAVESGEEAINHRTLSMAsYhGPSERRRQFERELM	.............................................................................................................Hl...h...ht.hss..p.-...RI..phlc.tsRWI.GYs..pA....phLsp.Lps.L.hs.h.P.p.pt.R..M...P...s....L.LlVGsoNNGKo.....h...Il.c+.F....p.+...p...H..........s..........s........s....s....D....s....c...t....c.....t....h.............PVlhlp.h....P..spP.s.....h....+h...Y.sul.L...s...tht...............A..P...h.......+.s.....p.........s....p.....l.....s.c...h..c..p.s..l...t..L...lR....c.h....s.l+M..LlIDEl.Hs..l.L.u.G.ss..h..p.....p..R.....p.h....L...N....h...L+.aL..uN..E...L...p..IP..l....V....u..V..G....T..............c..............-A...h....h.......A....l....p....o.D.......s.....QLt...s...R......F.....-......s......h.....h......L..P...h...........W.....c.....h....s.....c........-.....h.....p.....p...L.....L...sSF.t..ts.L....P...L..+.+..s.S.s.l.s..s....h...-.h.AphlhshSp.GslG-ls+LLhsAAlhAlcoGcEtIstchlp.......................h...................................................................................................................	0	9	29	48
+5450	PF05622	HOOK		HOOK protein	Moxon SJ	anon	Pfam-B_8981 (release 8.0)	Family	This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organisms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas the central coiled-coil motif mediates homodimerisation and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes [1], whereas both HOOK1 and HOOK2 are localised to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head [2].	35.00	35.00	35.00	35.10	34.70	34.70	hmmbuild  -o /dev/null HMM SEED	713	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.52	0.70	-13.24	0.70	-6.72	9	557	2009-09-11 15:29:52	2003-04-07 12:59:11	7	9	169	1	312	507	1	523.20	26	58.15	CHANGED	Ms...c.KhELC-SLlpWLQTFpluAPCpslp-LosGVAhAQsLpQIDPuaFsEuWLs+IKpD.VGcNWRLKsSNLKKILpulh-YYp-lLupplS-thlPDltpIuEpSDssELGRLLQLILGCAVNC-cKQ-aIQpIMsLEESVQ+sVMsAIQELho+cpssosus-shssh-pQL++hh.-LpEs.p-+-ELAQRCpEL-hQlhhL.EEKsuLhpENphLp-chsph-..........oh.sPsplsu++a.pLQpQLEQLQEEsaRLEuA+DDhRl+Cp-LEK-lhELQpRN-ELToLApEspuLKDElDlLRpuuDKsspLEupl-oY+KKLEDLsDLR+QVKhLEE+NshYhcpTlpLEEEL+KAsusRuQlEsYKRQVQ-LHsKLspESp+A-KhtFEh+pLcEKh-ALpKEKERLltERDoLRETs-ELRCuQhQtspLs.ts...ussu.ot-sLAAElhPsEhREpllRLQ+ENKhL+htQEGu.pp+.stLQphL--ANppppcLcoppRLsppRIhpLptQlE-LQKtLppQGu+s-s..sspLKpKL-tHhcpLpEsp-Elp+KpthlE-LpPctsps.spKIsELpsALppKDp-h+AME-RYK+YlEKA+pVIKTLDPK.p....AssEl.hL+p..........QLsE+DtclptLEp-h.cts+.hR-.EEpLIloAWYNhGhshQ+cAh-uRLsshus.........sGQSFLApQRpsTssRRshssp..s....souK	...............................................................l.h.Wl.po.....h........t..............t.................t...p.....h....pLssGhhhtplh.pI.sst..hs.......p.....p.l.p.p.p...sssshpl...+...h...pNLphllptlhpY.......hp-h..Lt.p......l.............lPs...l...........hIu.....c......p....s....s.........t.......E......l...t..................+L.L..Ll...LGCA.V........pC.ppKp.........caIppI.t.L....-.ssQt...........sl....hst...I.Q...E.....lh.p...........p......p....p.......s.....s.......p.........s....t......t....s.......t.p........h...-......t..t..........................p........p......h....h.....p.......l......p...c..h..ht....c..p..-.p.h..........t...p.......p.....h...t....-...h...p..p..l.....L.p.p...E.+s....s.L...............t..p.....p........h..t...p.p.h..s..p..p................................................................p.t..s.p.p.h.h.u.h...c....hh...p....h..p.t.p....lcpLpp....E..........c....h.....p...t..t.......h.Dh....+h.....ch.....p...ph..........-....t..c.....l..tclp...p.c.sp.p...............Lhs.....A....c.p...spth+DElD.LRppup+....ss+LEsplpph+.c.+Lp-..hp.h+tpl..ctLcEpN.t...hhhpp...p.h.L......E-pL....c.......t.s.p.......s.......t....p.s...p...l.....c.......p.......hc.+.......p...h.............p.Lptc.h.pp.ptp.ctp.....p..h...h-hp...p....lp.......cchp.....t....l.....cp.....p....t...p....l..........p.h...t....p....h.......p......p.......h......c.pL...c.hs.................t....t.....t.tt..............................st.s.p...s......h......s.t.El...............................t..h..p..p....p..hh....+.........L......p....hE......N.....p....L................t.........p.....t..............................................t..............h.t..........p....lc.pt...p...........t...h.t.....p.lc...pp............p............p.p........p.......h.....l......p.t.p...h....tp...p...p...t.....t.....p..tt..........pt...........p...t.p.h...pt.......th....p........ph.........t....p.t............................h..pp.....................................................................................................................................................................................................................................................................................................................................................................t...............................................................................................................................................................................	0	90	122	209
+5451	PF05623	DUF789		Protein of unknown function (DUF789)	Moxon SJ	anon	Pfam-B_9113 (release 8.0)	Family	This family consists of several plant proteins of unknown function.	20.60	20.60	23.40	21.40	18.60	20.40	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.98	0.70	-4.94	19	248	2009-01-15 18:05:59	2003-04-07 12:59:11	7	10	38	0	149	236	2	246.60	32	51.85	CHANGED	oNLERFLcusTPsVPsphhsp...sshps.psh.....pppphsaFtLsDLW-sFcEaSAYGhGVPl.......pLssu.-sVhQYYVPYLSAIQl.....ass.pphhs...................................Rp.s-su-st......S-u.Scsp...................thtpt.psushspst.....tsphGplhFpYhEpssPasR.PLs-KlspLupcaP...........tLpoL+SsDLuPuSWhSVAW......YPIY+IPss.slcDLsuCFLTYHoL..uoshpss.sp......................................t.spclsLPsFGLAoYKhpGslW..................ss..pts...p-....ppphtoLhpuADsWL+pl........pV.pHsDapFF	.............................sl-pFltsso.P.l.......hsp........tthpt.pth...............t.pt..hF.LsDlW-tacEhSuY..Gh..u..Vsl.........hLsss...c..plh..QYYVPaLSAIQl.asp..tt..............................................pt..pps.ptt...t..t..sps.st.t..............................................ptt.p.pt.........pt.s..hFpYhEpp..Pa...tR.PLh-K.........lppLupphs.............tLhohcosDL.PsSWhuVAW......YPIY+IP.s....s.pcl.s.ssFLTaHsL..usshptt.........................................................................................t..tphsLsshGltoY+hp..u.phW.............................s...t..p.......pphh.tsL.psAssaL+th.......................ps..pH.DapaF.............................................................	1	25	93	119
+5452	PF05624	LSR	LISCH7; 	Lipolysis stimulated receptor (LSR)	Moxon SJ, Mistry J	anon	Pfam-B_9152 (release 8.0)	Domain	The lipolysis-stimulated receptor (LSR) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids [1].  It is thought to be involved in the clearance of triglyceride-rich lipoproteins, and has been shown in mice to be critical for liver and embryonic development [2].	25.00	25.00	30.60	30.00	22.50	22.10	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.42	0.72	-4.23	3	176	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	39	0	70	137	0	48.90	70	8.91	CHANGED	cWLTVLlIllGALLLlLLlGICWCQCCPHsCCCYVRCPCCPsTCCCPE+	....-WLhVllVlLGuhLlhLLlGI.C.WCQCCPHoCCCYVRCPCCP-pCCCPc.....	0	3	9	27
+5453	PF05625	PAXNEB		PAXNEB protein	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_9269 (release 8.0)	Family	PAXNEB or PAX6 neighbour is found in several eukaryotic organisms.  PAXNED is an RNA polymerase II Elongator protein subunit [2].  It is part of the HAP subcomplex of Elongator, which is a six-subunit component of the RNA polymerase II holoenzyme.  The HAP subcomplex is required for Elongator structural integrity and histone acetyltransferase activity [2]. This protein family has a P-loop motif. However its sequence has degraded in many members of the family.	20.50	20.50	20.50	20.70	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.14	0.70	-5.62	30	316	2012-10-05 12:31:08	2003-04-07 12:59:11	6	5	262	3	225	365	7	338.60	25	89.19	CHANGED	oSFp++tht......................p..p......hP.....GlRPS.spsupsoTSTGsssLDplLuGH.GLPlGohLLIEEsuoT-auulLL+YFuAEGlVp..............spclaVsu.h...sppaspcLPGhhpsssppcccs.......................sppps-cMKIAWRYpplschpsussssp........................sasHpFDLTK+L.sps.hsslsalshsss.........................................................................................s.....asullpplpshIppp.........sssslhRlsIPSLLsPshYsspsupsp.......llsFLHuLRuLlRt.ss.psssllTlPhsLas+....ssuLsphlcpLsDuVIcLpPFstp.........cttsss....tK..pGLl+lpKLPsLs-+u.shhscps....DaAFKLuR+K.FpIEpauLPP--s-ppsppsst.....................sstsscpsLDF	....................................................................................................................hs.GhRsS.s.hs.u.p...hsSTGhssLD.plL...uG............GLslG.s..lL...............l.E...E..........st.............hs.s......authLh.+hFhApGllp..............spplhlhu.h...........stthhpp...L.......Pu.h..tssptpp...p.p.s...............................................................s.pp..ppphKIAWRYpth.sphpss.sssp................................................tasH.taDlo+ph...p.h.....tsph.hhh....t................................................................................................................................................htpllpplpp.hlppt.................ttpplhRlsl.u.LhuPhh...h..s.s.p.....t..sp.t......................lhpFLasLRuLlR..........s.........s.h.....s..........sshlTl.PhpLh...........sssl......hthlpplsDsllpLpsFstp.................pttts.....hct.p...Gll+lc+lPhh...sshs...shhspst.........................-h.uF+lpR++.FhIc.hplP.s..sptttptttt.........................................................................................................................................................	0	83	128	187
+5454	PF05626	DUF790		Protein of unknown function (DUF790)	Moxon SJ	anon	Pfam-B_9309 (release 8.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	20.20	20.20	20.60	20.60	19.60	19.90	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.14	0.70	-5.94	13	146	2012-10-11 20:44:44	2003-04-07 12:59:11	6	3	123	0	80	152	24	374.90	31	88.07	CHANGED	MLPpELLcs+.tpcGcIhPpaus....-cl-LAcpVIphF+pplGcphG-LpcclcplE.ptpNYKhVRGhA+lL.....cRp.spF-ssoslDPhclRchLFct....G.ssocpERpclLpc..........sAcch......sso.p-lE+ulaADhEEE+lLsch..............................PsIoP--Ll+pYNLSLlQTLlFcAhclsl....plsss...aKcllRtIKtLGLMYpl.s.............................................t.t.hplclsGPASLh+hoc+YGsulAKLlPtllpscpWpl+A-ll......pscRlYpFcLsSppshhh.chppt......................................................aDSslEcpFspchptlh.uhclhREP-llplGppsaIPDFhlp+.ssp+VYVEIVGFWT.EYL++KlEKl+csshshLlllscE.L....t.tphchsspcVIhF++.KIshscVhthL+	......................................................MLsp-Llph+..hpstplhPhahs.....pphpl...ApclIphFpttlGps..pu-LpcplppLp..p.................t.............Da....+lhRGLu+lL.................ccp.spFE.h.hu.sl-PtclRpplFpt..........sss..h.......p.......p.....p......R..ptsLpp..........lAppL......tl...pclpcuhYADLc-pphLsp.h...............................s..s...sP-pLlcpYNLuLsQsllacAsclpl.....pst..ss....aKtlh+h....lKhhtL..Mahlpt.............................................tsp.shplpl-GPsSLh.ctop+YGhphA+hlPsll.pssc.....WplpAplt............p....ts.p.+shphpLss.p.s.shh.s..c..h.s.s..s..p....................................................aD.StlE.psFupca..pp....h.....t.....p..sWpl.REs-hlsls....s..p.VhIPDFt.l..........p..................+..s.......sp.......chhlEIlGFWssEYLc+Khppl.cps.p.t...s...Lll.sssE..L....ussph..pt....hs..t.pllhF+p.plp.psVhphl................................................	0	18	52	69
+5455	PF05627	AvrRpt-cleavage	NOI; 	Cleavage site for pathogenic type III effector avirulence factor Avr	Moxon SJ, Coggill P	anon	Pfam-B_9342 (release 8.0)	Domain	This domain is conserved in small families of otherwise unrelated proteins in both mono-cots and di-cots, suggesting that it has a conserved, plant-specific function. It is found both in the plant RIN4 (resistance R membrane-bound host-target protein) where it appears to contribute to the binding of the protein to both RCS (AvrRpt2 auto-cleavage site) and AvrB, the virulence factor from the infecting bacterium [1]. The cleavage site for the AvrRpt2 avirulence protein would appear to be the sequence motifs VPQFGDW and LPKFGEW, both of which are highly conserved within the domain [3].	20.30	20.30	20.80	20.30	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-7.88	0.72	-4.91	22	371	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	42	2	166	352	0	36.90	43	27.04	CHANGED	spcpspslPKFG-WDsss.PASA-GFTVIFsKsR--Kcos	......t...ptssVPKFG-W.D.sss...susupsaTslFsKsR-cKps.s...	1	22	94	132
+5456	PF05628	Borrelia_P13		Borrelia membrane protein P13	Moxon SJ	anon	Pfam-B_8766 (release 8.0)	Family	This family consists of P13 proteins from Borrelia species. P13 is a 13kDa integral membrane protein which is post-translationally processed at both ends and modified by an unknown mechanism [1].	25.00	25.00	27.00	27.00	19.50	23.20	hmmbuild  --amino -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.79	0.71	-4.36	5	121	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	37	0	9	87	0	126.40	51	78.98	CHANGED	TsLpYESpKsslL.APFLLNLFLoFGIGSFVQGDYIGGGAlLGoQVLGGILllTGhIlss....ssssssp.huIoGtlLhGIGsLTIAuSYITSIIIPFTFANRYNANL+K+LGIuLAGFEPNFDIGIN.....G...FQLSFKKSY	.............hhhY-opKpssl.sPFLLNLFLsFGIGSFsQGDhlGGuhlLGF.....shlGhhL.hhsGhh..L.sh..............s.spcs...hhhGthlh...hhGssThsso+lsplIlPFTFANpYNcpLKppLslsLuGFEPsFDluhs.....G.....FpLSFKKSY.......................	0	5	7	7
+5457	PF05629	Nanovirus_C8		Nanovirus component 8 (C8) protein	Moxon SJ	anon	Pfam-B_9354 (release 8.0)	Family	This family consists of a group of 17.4 kDa nanovirus proteins which are highly related to the faba bean necrotic yellows virus component 8 protein whose function is unknown [1].	25.00	25.00	151.80	151.70	17.50	17.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.07	0.71	-4.42	3	31	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	9	0	0	30	0	151.80	70	100.00	CHANGED	MADWFcSsLKTCTHVCDFscIuuDS...QQ-lhCCDSM+GKLp-PRKVLLVSCpVSFNGSFYGuNRNVRGQLQlSMp-DDGVsRPIGYVPIGGYLYHNDYGYYEGc+TFNLDIESDYLKPDEDasR+FpVSIlN-NGLD-pCDLKCYVVHSlRIKV	M..DWAESQaKTCTHGCDWKsISSDSu-NRQYVPCVDSGsGR.KoPRKVLLRSIEssFNGS..FpGNNRNVRGFLYVSIRDDDGtMRPVLlVPFGGYGYHNDaYYFEGcupspCDI.uSDYlsPs.DWSRDMEVSISNSNNCN-.CDLKCYVVCSLRIKE	0	0	0	0
+5458	PF05630	NPP1		Necrosis inducing protein (NPP1)	Moxon SJ	anon	Pfam-B_9369 (release 8.0)	Family	This family consists of several NPP1 like necrosis inducing proteins from oomycetes, fungi and bacteria. Infiltration of NPP1 into leaves of Arabidopsis thaliana plants result in transcript accumulation of pathogenesis-related (PR) genes, production of ROS and ethylene, callose apposition, and HR-like cell death [1]. 	21.00	21.00	21.10	21.10	20.30	20.90	hmmbuild  --amino -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.56	0.70	-4.60	27	493	2009-01-15 18:05:59	2003-04-07 12:59:11	6	12	160	3	323	429	0	179.10	32	74.56	CHANGED	sssshthcapPhlch.scGChPhPAlsssGssuGGLps........o.Guh................................suuC+-put..suQsYuRusp..N..G..hhAlMYuaYF.KDpshs..shGuHRHDWEaVVVWlss....ss.plhtVosSuHGsappt.s.sssph-Gs+sKlsYapshss.sHshchsssss-..........p.sLlsW.....sshss.ssRctL.......pssDFGsA.......slPh..KDusFtspLspA	...........................................................................s..phhhpapP.Lch..s.sGChsaPAVss.sG.s..s...uu.G..Lps.........o...Gs..s.............................................s.usCpsss....uQ.......l........Y..sRush..s....s......hhA..IM.YuWYFPKDp.s.....ss...............s..h....G.HRHDWEpl.l.V.Wlss......................ss..pl...h.u.l..u...sS...s.H.u..s....app.............t............s..........s............h.....s....G.....s..psp.ltYhtsh.h......sHthphsss..s........G.....p.....................htsLlhW..............-thss....suRsu.L.......p.s.s.s.FG.p.A........p.h.Ph..pDs.sF.tpLtt..................................................................	0	86	163	303
+5459	PF05631	DUF791		Protein of unknown function (DUF791)	Moxon SJ	anon	Pfam-B_9328 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.28	0.70	-5.76	3	263	2012-10-03 03:33:39	2003-04-07 12:59:11	9	6	145	0	180	646	62	301.10	33	72.54	CHANGED	FYYLVFGGLAAVVAuLELuKouKDRlNToPuFNSFKNNYLLVYSlMMAGDWLQGPYVYYLYSoYGFuKGDIGpLFIAGFGSSMLFGTIVGSLADKQGRKRAClTYCIlYILSCITKHSPpYKVLMIGRlLGGIATSLLFSAFESWLIAEHNK.............................RGF-sQWLSlTFSKAlFLGNGLVAIISGLFANLLADsFGFGPVAPFDAAACFLAIGMAIILuTWSENYGDsSDsKDLlsQFKVAApAIASD.plhhLGtlQSLFEGSMYTFVFLWTPALS..PNDEEIPHGFIFATFMLASMLGSSlAuRLLuR+.LRVEuYMQIVFLlSAsoLhLPIVTshLVsPSpVKs-GLSLsuulQLLGF	......................................................................................................................................t....sF.pF..p.pal...hVY..L..h..h......su...D....W....LQ....GP...Y.l.Y....h.....L.Y.p.p..Y.u..hsct....p.....I.u.h.L...a...l..s.Ga..u.S..uh.l.h.....G.s.h..s.....G.....s.....L.....u.Dp.h.G.R+p.u....C.l.h..a..s.l.h.Y.........l..s....C.....l......o..............K..h.s.s..p.a..h.....l.L.h.....l.GRl.L..G.Gl....u.T.....o..LL..F....S...s.F.E......u...Wh..l..t..E...H.t.c...................................................................................+..s.a...s....t..p...h..L..sh..T.F.u.pu.s.......hh.N.ul..l..Alh.uG.l..hup....hl.s..s.........h.........h..u....h............t.............lu.PF..sA..h.shL...s...l.u..hs.l....lh.tsW....s..E....N...a.G..s.............................t......p...p..........s.....h...........................t..p.h.....t...t........u...h........p....s............l...h...s........D............p+....l....hhLGh.h..Qu.lFEu.uh..Yh..F..VFLWTPs..Ls.............spt....t...........t....l....P....h...Gh....lFus.FMhupM....lGSslh...hhhs........p.p....hp..s...t..hh..hshhh..sshsh.h......................................................................................................................................................................................................................................................................................................	1	75	112	149
+5460	PF05632	DUF792		Borrelia burgdorferi protein of unknown function (DUF792)	Moxon SJ	anon	Pfam-B_9387 (release 8.0)	Family	This family consists of several hypothetical proteins from the Lyme disease spirochete Borrelia burgdorferi.	25.00	25.00	36.90	36.70	23.10	22.30	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.46	0.70	-4.99	2	136	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	28	0	10	109	0	194.90	67	97.49	CHANGED	hsIKNKN..NsNhEpKK.tEh.p-.......EIhpII+DlhTQlFsLFGADNFLlLFPR.Dh+GFGYVPQLFFIKPKTpLIoRTYNTSCSKRPsINYYDRKAEYVSYNsVMTGEpISLsGGILTShYKDMLSlhKhTVFGNhhhRFDuHLsKEQLANRlQAQVPFoIYSPTFGLKELAlITsLoFKDhPFIDEVEVSLShElVKTFcLEKYKG	........................................pph.tp...p.......EIo+II+DVlTQIFALFGADNFLVLFPRhDLKGFGYVPQLFFIKPKsELIoRTYNTSCSKRPV.INYYDRKAEYVSYNPVMTGEpISLNGGILTSLY.K-.MLSlLKMTVFGNohLRFDuHLsKEQLANRlQAQVPFSIYSPTFGLKELAlITSLoFKDTPFIDEVEVSLSlEIVKTFs..LEKYKG......	0	6	6	6
+5461	PF05633	DUF793		Protein of unknown function (DUF793)	Moxon SJ	anon	Pfam-B_9395 (release 8.0)	Family	This family consists of several plant proteins of unknown function.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.40	0.70	-5.71	7	188	2012-10-01 23:20:42	2003-04-07 12:59:11	6	6	24	0	111	233	0	230.20	22	80.18	CHANGED	hPAT-aQu........hhShLSlRRsQhss......ssspppE.p....EL-sFQ++VAE+FhDL........usSs.........tslLSlpWltKLLDsFLsCppEF+uIlhstts..QISKsP.hDRLls-hh-RulKALDlCNAlhsGl-plRQap+hhEIsloALcpp........PLG-GplRRAK+ALhsLsIuh.s-....Ksuuuusss..ppNRShsRshs.........ht+RohG............ph+S.oWuVSRsWSAuKQlQAhsuNLssPRus-ssu...Ls.PVYhMoSVhlhVMWsLVAAlPCQ-R.GLtsHhs.sP+phpWAuslhSla-+Ih-E.K++-+Kp.usGLhcEhpphE+hu+.L.EhsDuhcFPhs--c.p.EVtpcVpEhhplCcthcsGL-PhpRpVREVFHRlVRSRoEhL-sL	................................................................................................................................................................................................h..hsh.ah..hh..h....ttht.hh...........h........-chh..hh-.sh+hLDlh.sht.tlt.l..pt..phhh.hsht.h....................................................................................................................................................................................shh.ht..hhhh.h.hhs.hh....s......................t......au.sh..l.p.l.t-.t...........tt............................h.htEht.hc.....h............hht............t................................................................t.....h...h........................................................................................................................................................	0	21	78	93
+5462	PF05634	APO_RNA-bind	DUF794;	APO RNA-binding	Moxon SJ, Eberhardt R, Barkan A	anon	Pfam-B_9606 (release 8.0)	Family	This domain contains conserved cysteine and histidine residues [1]. It resembles zinc fingers, and binds to zinc [2]. This domain functions as an RNA-binding domain [2].	25.00	25.00	33.30	25.70	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.32	0.70	-5.13	7	186	2009-01-15 18:05:59	2003-04-07 12:59:11	6	9	21	0	116	189	0	158.30	36	77.96	CHANGED	Ls......ptht.ts.spppp.psp.sDlP.....+.c+KPaPhPhKclpcRAKEchp.tp.t.p+.L..PPcNGhlV.pLVPVAcpVhpARphLlpsLspLl+..VVPVpsC+aCsEVHVGshGH.h+oCcG.ssstRpu.HpWssGslpDVllPlEuYHLaDphs+.RIpH-pRFshPRlPAllELCIQAGV-lP-aPs+RRppPlh.htt.cllD	...........................................tht.............................................................................thh.lApcshpA.aptlhpGlp+Lhc...hhsVpsCtaCsEVHVGshGHph+....h....Ctuh.cpptRsGpHsWppusl-DllsPh.saHlhD.h..Gt.......lp..c-.hRh.Ys+hPAVV....ELClQAGspl.P.c..............................................	0	10	68	94
+5463	PF05635	23S_rRNA_IVP	Ribosomal_S23p;	23S rRNA-intervening sequence protein	Moxon SJ, Eberhardt R	anon	Pfam-B_9648 (release 8.0)	Family	This family consists of bacterial proteins encoded within an intervening sequence present within some 23S rRNA genes [1-3]. It folds into an anti-parallel four-helix bundle and forms homopentamers [4].	23.30	23.30	23.40	23.30	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.20	0.72	-4.15	122	1034	2009-09-11 08:57:14	2003-04-07 12:59:11	6	5	486	10	434	1051	267	104.30	26	82.27	CHANGED	psac...-LclWp+uhcLshplYc.lopshP.p.cpauLpsQlcRuulSIsoNIAEGhuRp..osp-ahcFLtIApGSssElcopLhluhclsalsp.pph......ptlhpphpclp+hlsuh	.................................hppl.happuhphshplap.hs.p...ph..s.p...p....c...p..a...s.L.ss.QlpRu..........usSlsuNIAE.Gh..s...+p..opp-ahphLpIA.......tuShtE.hph.L..ls.hc.hs...a..l.s.p..p.ph......pt.lhpphpplhphl.t.h..................................................................	0	178	349	412
+5464	PF05636	HIGH_NTase1	DUF795;	HIGH Nucleotidyl Transferase	Moxon SJ, Anantharaman V	anon	Pfam-B_9692 (release 8.0)	Family	This family consists of HIGH Nucleotidyl Transferases	19.90	19.90	19.90	19.90	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.40	0.70	-5.43	10	1483	2012-10-02 18:00:56	2003-04-07 12:59:11	6	2	1444	1	204	1046	11	364.90	35	97.14	CHANGED	McssGIIsEYNPFHNGHhYHLppucc.spssltIAVMSGsFlQRGEPAIlsKWpRucMALpsGsDLVlELPssaSsQuA-aFApGAVcILspLu.l-sLsFGSEpsslccapclAclhs-+ttchcphl+p.L.scGhSYPpuppcsac.....phtG.c.thp...htoPNNILGlpYsKAlhptspsIpshoIKRpuAsYHDt-l...ccphASATuIRptl.......................tpclctlc+hVPssohcll....p.hsshsshscaFshLKYpllt.osccLcsIapVsEGl-sRlh+ulppupsac-hlcLlKTKRYThoRlpRlLTalLlNhcp.........psstssaI+lLGFocKGQpaLpphKKshs.....lPlIT+luptshct.....hph-l+AopIYpLs.....ppshspp-Fs+sPI	...........................................MphsGlIsEYNPFHNGHtYtlppu+p...t.s...s...l....h.I.s.lMSG..NF..lQ..RGEPAIlsKWsRAcMALpsG.sDLVlELPhhhulQuA-hFApGAV.plLstLu...l-.s...lsF.......G.o.E...ps.plps...hpplAchhp..cp....t...t..ph.p.ph.lcp.h.p.p.u.hSYPpthp.t.hh.p.........................p.h.h.t......p...hphs............tsPNsILGlpYhKAl...t.....h..s..p..s..IphhsIpRpu.....usaHst....ph...............ctp......hAS....ATuIRptl..........................................................p..p......s..t....l.cp.h....lP...psshthh........................s.....s...h...h..s......h..c...pa.......as..h....L........+.Y...pl...l..........t...otp..c......LpsIap..l..sE...Gl....-sRl.........pps....l....p..p.......u....p......o......hcc.....hlctl.KTKRYThsRlpRllhalLlshp...t...........................tppt.sp.hl+lLGhsc+Gp.paL+....plKpp.........lsl....l...o..+l.sp...p.......s.h..ph........................hthph+As..p..lYph........st.....ppsasp.s.............................................................	2	79	138	173
+5465	PF05637	Glyco_transf_34		galactosyl transferase GMA12/MNN10 family	Wood V	anon	Pfam-B_6000 (release 8.0)	Family	This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of C. elegans homologues where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.	20.40	20.40	20.50	20.40	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.58	0.70	-4.86	14	639	2012-10-03 05:28:31	2003-04-07 12:59:11	7	9	211	4	419	634	57	209.70	22	55.28	CHANGED	pssclVllhuSs.pss.....s..tp.hltpslcN+l-YAc+H..........GYshhahpssshhh...thsss....WuKhPhl+psMpcaPcAEWIWWlDpDAllhshphsl.chhh..phLpphhhpp...........sshpph.cpshs.cupshhhlhspDasGlNuGSFLlRNspauthllDhWs..............-Phhtppsts...pcEQsALsallttHsplhsphuhls.................+hlNuYp.ut.t...............................hs.c-GDhllHFsGCpstssCt	..............................................................................s....hlhlhh.p.t.h............h..p.hpN+hcYschH...................Gaph.h.h.....tshhp.........tphtt................Wt.Kls..hlRphh...h......taP..c...sc......ahaalDt-shhhs.shp.........................................s.pth.p...h................p..s.....s..lh......p...p....shtu...l..NsGsFllR..s........spWu....h...hL.-.h.Wh...........................h.hh......t.h.......tt-.QsAl.....hl....h...t.............p................h....htp..hs.hl..............................................tchh.p.t...a..t.................................................ht..pch.s.hlsphsGCp.t...............................................................................................................................	0	104	243	356
+5466	PF05638	DUF796		Protein of unknown function (DUF796)	Moxon SJ	anon	Pfam-B_9698 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	21.80	21.80	21.80	21.80	21.30	21.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.75	0.71	-4.15	152	2770	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	1013	13	450	1429	75	135.10	28	72.81	CHANGED	alpl.s...G.....Is.........G.pstpp..s.HccpIplhuasasls.shs.......sutssGpsshpslphsKhlD+uSPhLhpuhss.Gcplppsplphh+.....ssG............p.t.cYhplpLps.shlsslsssss.............tt.hshEslslsYspIphpap	............................................Ylpl.s..G.......Is..............G..pshtp....s..Hcsp..I.lhuapasls....s..........su.....tsuGps...shpshphsKhlD+uo.PhLhpuh....ss......Gcpltp.....splph.hR......sssG.............p....cYhphpLps.shlsslshphs......................ttphp.hEplslsYpcIphpa.h.........................	0	69	183	306
+5467	PF05639	Pup	DUF797;	Pup-like protein	Moxon SJ, Bateman A	anon	Pfam-B_9797 (release 8.0)	Family	This family consists of several short bacterial proteins formely known as (DUF797).  It was recently shown that Mycobacterium tuberculosis contains a small protein, Pup (Rv2111c), that is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl carrier protein (FabD) [2]. Pupylation of FabD was shown to result in its recruitment to the mycobacterial proteasome and subsequent degradation analogous to eukaryotic ubiquitin-conjugated proteins. Searches recovered Pup orthologs in all major actinobacteria lineages including the basal bifidobacteria and also sporadically in certain other bacterial lineages. [1] The Pup proteins were all between 50-90 residues in length and a multiple alignment shows that they all contain a conserved motif with a G [EQ] signature at the C-terminus. Thus, all of them are suitable for conjugation via the terminal glutamate or the deamidated glutamine (as shown in the case of the Mycobacterium Pup [1]). The conserved globular core of Pup is predicted to form a bihelical unit with the extreme C-terminal 6-7 residues forming a tail in the extended conformation. Thus, Pup is structurally unrelated to the ubiquitin fold and has convergently evolved the function of protein modifier.	20.10	20.10	20.10	20.10	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.44	0.72	-3.48	15	351	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	337	8	108	262	19	65.20	44	96.99	CHANGED	Mus+csGGGQpcsscptpt.t.....ssssussptRpcclo-DVDDLLDEID-VLEpNAEEFVRuYVQKGGp	............................ttt...........ttpt.p.......ptt....stssssuppppc..ch.s.--l.DDLLDEIDsVLEpNAE-FVRuaVQKGGQ..	1	32	78	100
+5468	PF05640	NKAIN	DUF798; 	Na,K-Atpase Interacting protein	Moxon SJ	anon	Pfam-B_9801 (release 8.0)	Family	NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localise to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane domains but otherwise no other characterised domains. NKAINs may function as subunits of pore or channel structures in neurons or they may affect the function of other membrane proteins. They are likely to function within the membrane bilayer [1].	20.00	20.00	21.20	21.30	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.50	0.71	-5.36	13	270	2009-01-15 18:05:59	2003-04-07 12:59:11	9	2	79	0	133	229	0	164.50	53	73.51	CHANGED	MGsCSG..RCoLlhlCsLQLlsALERQVFDFLGYQWAPILuNFlHIllVILGLFGTlQYRsRYllsYslWssLWVsWNlFIICFYLEV.GpLS+.............................DoDL.LTFNlShHRSWWhEpGPGClsp.ls..sushshcs++hloVsGCLLDYpYIEVlHSuLQIlLALhGFlaACYVsplhh-EEDSFDFhsu..................PhYho....s	.......................................................ls.sLERQlFDFLGY...QWAPILuNFlH.IlhV...ILGlFGTlQYRsRYlhsYs.lWhsl.....WVsWNlFIICFYL.EV.GsLS+.............................DoDl...hTFNhShHRSWWhEpGPGChhp.s...ss...................hs.cspphloVsGClL-apYlElhHSu...lQIlLA.LhGFlaACYVsphhhEE..EDoh..ch.............................h........................................	0	21	34	71
+5469	PF05641	Agenet		Agenet domain	Bateman A	anon	Pfam-B_2551 (release 8.0)	Domain	This domain is related to the TUDOR domain Pfam:PF00567 [1]. The function of the agenet domain is unknown. This family currently only matches one of the two Agenet domains in the FMR proteins [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.17	0.72	-3.82	34	609	2012-10-02 16:56:36	2003-04-07 12:59:11	7	25	73	4	302	580	6	67.00	32	12.42	CHANGED	hppGstVEVpSccpsh..csuWatAhllpt.sct.....chpVcapshphpstts..............hp-plshpp.....l....RPsPP...	..................tcGscVEV..h..S.cs.ssh...suWahApVhhhpuc..............hahlcYsshs.ss..........................hsEhVshcc...................l..R.PssPs..t...............................................	0	52	141	206
+5470	PF05642	Sporozoite_P67		Sporozoite P67 surface antigen	Moxon SJ	anon	Pfam-B_8657 (release 8.0)	Family	This family consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in cattle. The antigen has been shown to contain five distinct linear peptide sequences recognised by sporozoite-neutralising murine monoclonal antibodies [1].	26.10	26.10	27.70	27.30	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	727	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.25	0.70	-13.24	0.70	-6.67	3	31	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	10	0	10	32	0	320.00	20	85.01	CHANGED	MpIlHFLLTIPVIFVSGGDKMPAGESPRTSKPSPLVTLESAlTQPSKDP...FKTVuALSKATKVWKSAVSlSDDSKTVPTPVSEPhITRSFQEP..................VSQESElQs-TEhNpuscGS+oDSE-DDD...............................................-pEEEDNKSTSSKsGKGSpKu.QPGVSoSSGSTTSsTssoTslSQTGLG..uSGSH....AQQDPuVu.sGV.........VGVPGLGVPGVGVPGsG...GsGshPGVGVstsGVuPGVGVG...........................G.GGV..........................PGVGl......................................tSsoSpEG--sDDpEc-t-s+shp.......................................................................PGVGlPGVtV...........GsoTSSoSTToPSoSTTTTTPoSSG.PSs.Gu.GoSsRNAVTRpTDSISGPIPSPG-PRAITGQM..........GEcEpFAVQFLGDFKPKPRRYEGscT-ssKLKKFIFEEVKSLVpTLINLKLAIANDFVEITEKLKKpNQNHVPKLKLLKGsQFDTKQKVANVLKGFNSLYFVlFMNLNLAKEVN+PEELAEhLWKLNTIPDKVu+EFELAlEKTKuSEKKsELEEAFKSIslGFKIAYYATNDILSSITNSVYsLIKLKNFGDDFVTEVRKSLQMVPHQKNLNGSSFIVKISEhMNKKGTEsQDQTSGuGS..............KGTEGGSLRG.DLTEEEVLKVLDELVKDVSEEcVGIGDLSDPSSRSPscKPAcLGPSLVIpNVPSDPoKVTPTQPSNLPQVPTo.....G.GNGT-Gs-QsPuusNG......................oGNGEGGKDLKEGEKKEGLFQKIKNKlLGSGFEVASlIIPMTTIIFSIVH	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ss.......................	0	1	5	5
+5471	PF05643	DUF799		Putative bacterial lipoprotein (DUF799)	Moxon SJ	anon	Pfam-B_9829 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function. Some of the family members are described as putative lipoproteins.	20.20	20.20	21.60	20.30	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.47	0.70	-5.02	3	303	2012-10-01 20:48:06	2003-04-07 12:59:11	6	5	289	0	76	216	14	207.60	45	91.96	CHANGED	MKPLILGLAAVLALSACQVQKAPDFDYTSFKESKPASILVVPPLNESPDVNGTWGMLASTAAPLSEAGYYVFPAAVVEETFKQNGLTNAADIHAVRPEKLHQIFGNDAVLYITVTEYGTSYQILDSVTTVSAKARLVDSRNGKELWSGSASIREGSNNSNSGLLGALVGAVVNQIANSLTDRGYQVSKTAAYNLLSPYSHNGILKGPRFVEEQPK	.......................................................................................h.hh........h.....hs.s..sl..h..L..ouC.s....st.....s...p.h..D.Y.o..uF..KpSKP+S.ILVLPPlNcSsDVpAoauhLo.psTh.P.LA.E..uGYYVhPVA.lV-ETFK.QNGLTsAuDI..puls.PsKL+cIFGADAsLYloVspYGTsYpllsSsTpVoAsA+LVDLRoGchLWs..G..S..A...o.s..p...-........s.u..s..s..u...s....u....G.....L.lGhLVs....AsVpQIsso...loD.cuapluuhsuspLLSs..sp.s...G.lLhGPR........usth...........................................................	0	15	39	58
+5472	PF05644	Miff	DUF800;	Mitochondrial and peroxisomal fission factor Mff	Moxon SJ, Eberhardt R	anon	Pfam-B_9868 (release 8.0)	Family	This protein has a role in mitochondrial and peroxisomal fission [1].	21.10	21.10	21.80	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.72	0.70	-4.74	9	222	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	83	0	105	189	1	189.30	36	94.98	CHANGED	huE.scl..EhcYTcsISppMRVPc+lKssush.--p.hhspsss..........cph.MpVPERIVVhGpspch.shStPR-lpL.pSs....P..uhlplpTPPRVlTLo-+.hs.h-.Estssssss...........spE.+shsph+Rtpusucsu.hppsupls+sD..............uhh...................s......u....p.........................shsshssslEshosc.tls...sLRRQIlKLNRRL.hlEtENcpRtpREhlhYulslAaaLlpoahWLpR	...................................................................................................h..p.tasptIsppMRlPcpl+sss.....t.....p.......t........hpp.t...............tph...MpVP-RIllh.Gpstc................hs...P.t.-ltl.puh........P...t.ltlpsPPpllTLscp....hs.h.p.pt.....t..................p..h..s.phhc.ts....s........tptt...ptt.......................................................................................................................................................................ths...hts.hp...shs.c.plh....LRRQlhKLNRRl.hLE.pstpRtpREhlhYslsluahllpsahWhpR.....................................................	0	24	33	63
+5473	PF05645	RNA_pol_Rpc82		RNA polymerase III subunit RPC82	Moxon SJ	anon	Pfam-B_9884 (release 8.0)	Family	This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa [1].	21.90	21.90	22.30	22.00	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.51	0.70	-4.85	29	304	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	256	2	191	294	1	231.10	19	43.22	CHANGED	sthhcLhpppal.plsp....s.....t.h.tpthpph..ssshsphcpps-sc.phptphtshhppsp.sh........t...t.ht..suh+t.......................hcssls..hphNh-+FphphRsptLlphs........................cs+lGpsouplYcthL+hhcppssshpts.............................shshosp-lt+tl.spshslpts............................................................................................................phlspaLpLLusss.htFlpchus...GpahVsapclhppL	.........................................................................................................h.pLhtttal.ps.......................t....h...tt........s.....t.ph....hpt.....p..h...h.....htt..htphhpt..sph.t..............pt.tt..hs.t.sput+ptt.........................................pts.h..-sslh..hplNa-+FthphRsptllshs..........................ps+hspsouplh...cshLchs..chpssp.ht.........................................ohshohspIhcpL...tphs..lsts............................................................................................................................................................................................lppaLplLspss....hhtc.....t.......s.ahl.hpphh..............................................................................................................	0	53	97	151
+5475	PF05647	Epiglycanin_TR	DUF801;	Tandem-repeating region of mucin, epiglycanin-like	Moxon SJ, Coggill P	anon	Pfam-B_1480 (release 8.0) Pfam-B_13922 (release 26.0)	Repeat	The unusual mucin, epiglycanin, is membrane-bound at the C-terminus but has a long region of this tandem-repeat at the N-terminus [1]. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells [2]. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which makes it likely that its function is dependent on its glycoforms. Cells expressing Muc21 are significantly less adherent to each other and to extracellular matrix components than control cells, and this loss of adhesion is mediated by the TR portion of Muc21 [3]. This family also now contains the repeat that was the C. elegans protein of unknown function (DUF801).	27.00	14.00	27.00	14.00	26.70	13.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-9.97	0.72	-4.17	6	290	2009-09-10 21:16:35	2003-04-07 12:59:11	6	13	12	0	150	263	0	55.90	52	110.76	CHANGED	sossuoSTsSuuASTssNsuSS.sTSuuTSTsosouS.SsTSSGoSTAsNsASosTTuuSuTtssTGTpTTo	......tstuST.sSs.usSTuTNopSS..sTS.SGsSTsTNScS.STTSSGuST....ATNStSSsTs.......................	0	114	114	114
+5476	PF05648	PEX11		Peroxisomal biogenesis factor 11 (PEX11)	Moxon SJ	anon	Pfam-B_2629 (release 8.0)	Family	This family consists of several peroxisomal biogenesis factor 11 (PEX11) proteins from several eukaryotic species. The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes.	23.80	23.80	23.80	23.80	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.33	0.70	-5.08	61	883	2009-01-15 18:05:59	2003-04-07 12:59:11	9	7	300	0	540	829	5	206.20	18	85.16	CHANGED	lsphlcalsposGRDKlhRslQYsu+hluhhh.pp...s..stphsshhcpl.....csphohsRKhhRhh+slstlpsutthh..sp.t......Dsll+hhsllppluhuhYhshDplsWlsphGlhpspstp....+hsphusthWhhuLlhullpslhplhthppphpphtt........................psscsspptp.................phtpcphshhhsllpshsDlhlslstL...uhl...phssshlGlsGhlSSllGlhsha	...........................................................................h..hhtp...ut-+hh............+h.hpah.sphh..h....................................t.t.............tt.httl.........................ptp...huh...sRp..............h...hRhh....p.........l....phhp...thh..th...........tp......................s..h..hphh...t.......h..h...p...p..hs.shYh...h...h....-pls....a.......l..s.....p..h....Gl.....hs......hpttt...................phtp...........h.ush....h....W.h.hullhulht....p..hhplhth.tpptp.phtt.......................................t........p.........................................................thhppp.h.hhhsllp..shsDhhhslstl......thh........ths.sshlGhhGhhSulhuhhp.......................................................................	0	168	289	432
+5477	PF05649	Peptidase_M13_N		Peptidase family M13	Studholme DJ	anon	Swiss-Prot	Family	M13 peptidases are well-studied proteases found in a wide range of organisms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure  regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk. 	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.46	0.70	-5.42	156	3507	2009-01-15 18:05:59	2003-04-07 12:59:11	8	35	1646	10	1445	3238	341	342.10	22	54.54	CHANGED	s-DFYpassGsWlcpssIPs.cpsph..............us.FspLpc...pspppl+.............................pllcph...tt.t.............................................................................................................ssstp+htshYpushD.hssh...........cptGhpPlpshlpp.lsu.h................p............spts........................................................................ltphluph....hts..............shhsh.h.....VssDh..cs...s...sp....hlhlsp.......su.luL..PccsYYhppp..................................tphhpsYp.paltclhph......h......G..............................ht.s.............pspptAp...plhshEp.pLA............phphsp......tcpcc.pph................Ys.hsh.......s-Lpph.....h..ss......ls.............a.pphlpshhh.............................st........p...pllltp.....................ss...ahptlspllps...sshp.....slpsYlhaphlpshush..Lspshpptphpa.t......................sltGhtp..ts......+hcp.slsh.ss...st..lGpslGp............hYVcc..hFssc.u....Kpphpphlpslppuapppl...p.shsW.......Mssp....TKppAh.pK..............Lsshp.cI.GYP	...................................................................................................................................pcDFapass.G..t.....W..hpp..t..lPs......spsph......................................us..Ftt.L.t.c...p..pp..hlp.....................................phlpp........................................................................................................................................................................................ss..pph.t....phYpts.....hc...pth.........................cth.G......h....p...P..l..h.......t.hlpp...lt..s.....h..........................................sh.s....................................................................................h.phl.s..p.ht..htht.s...................hhsh.h......lssD.....ps...s.......pt.........hlh.hst................su..lhL........PspsYYhp.pp.........................................tphhptah..phhtphhth......h.............u..........................................................h.t.p......................psp.p...hp...p.llphEp...plA.......................phhhsp.........tcp...p..-..t..th.................................Yp.hs.h.......s-.hpph............hst...........................................hs...............h.ttahpthh..............................p.s.....p.......plll.p..........................p.....ah....p....t...h..s..p..ll...sp.............p.s..hp..................hhps.a..hh.h.p.hl.p........thssh.....Ls.p.php..p.h.pht.a.t...............................sl..Gh.p......s............ph+t......shph.sp...........s....h...s.slGt........................................hYspp.....hF....s...p...u..................K...t....p.........h.pp....h.l.pplhp.......sa.pppl............p...p........s.W.......h..st.p..T+p..pAh.tK..............lst..ht.tl.GYP..................................................................................................	0	507	719	1169
+5478	PF05650	DUF802		Domain of unknown function (DUF802)	Yeats C	anon	Yeats C	Family	This region is found as two or more repeats in a small number of hypothetical proteins.	22.60	22.60	23.10	24.10	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.57	0.72	-3.85	40	307	2009-01-15 18:05:59	2003-04-07 12:59:11	6	8	124	0	97	342	6	53.40	35	15.48	CHANGED	losph-sosuslAs.......sWspALApQppuspuLsppLcsuLsphApsF-p+uuuLl	........losth-sosuslus.......sWpsALApQppuscsLupphpsuLsphusoF-p+SAuLl...........	0	13	31	67
+5479	PF05651	Diacid_rec		Putative sugar diacid recognition	Yeats C	anon	Yeats C	Family	This region is found in several proteins characterised as carbohydrate diacid regulators (e.g. Swiss:P36047). An HTH DNA-binding motif is found at the C-terminus of these proteins suggesting that this region includes the sugar recognition region.	21.40	21.40	21.40	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.50	0.71	-4.75	54	1274	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	1153	0	179	746	9	132.30	47	35.86	CHANGED	LsppLAppIVpRsMplIsaNlNVMsppGlIIuSGDspRlGphHEGAlhulspp+slpIspsssppLp.GV+.PGlNLPlhapscllGVlGITG-P-plptauELV+hsAELllEQuthhcphpWcpRtpEchlhpLl	..................LcsphAQcIVsRsMcIIs.p..N.INVMD.tcGhIIuSGDpcR.IGph.HEGAlLsLs.ps.....+.s.V-.I.-c.s.s.AppL+....G.V+.tGINLPLp.h.c.scllGVIGlTGE.P.-plRpYGELVpMsA.EhhlEQspLhc..lt.-pRh+EEhlhpLl.............................	0	51	97	134
+5480	PF05652	DcpS		Scavenger mRNA decapping enzyme (DcpS) N-terminal	Moxon SJ	anon	Pfam-B_9894 (release 8.0)	Family	This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the N-terminal domain of these proteins. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway.	25.00	25.00	28.80	27.30	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.49	0.72	-3.68	20	268	2009-01-15 18:05:59	2003-04-07 12:59:11	7	6	220	18	181	258	0	107.40	33	32.37	CHANGED	pphlscFchp+lLspsspsKsIsLLGpls.......s..csAIlllEKTsFph...-pl............................huhhss.................hpplcpltpNDIYtWhlshhtpcls............slKlsLIaPATppHI+KYspQ	...............................................t..lspFchp+lLsp...........ssp..sKpls.LLGp.ls...............s..csAllllEKssFth.....-ps.........................................hshhsu......................htclp..lhsNDIYthahshssp....p...hs..............................slKlslIaPAT-pHIcKYppQ...............	0	52	88	144
+5481	PF05653	Mg_trans_NIPA	DUF803;	Magnesium transporter NIPA	Moxon SJ, Eberhardt R	anon	Pfam-B_9876 (release 8.0)	Family	NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters [1,2].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.95	0.70	-5.46	7	1396	2012-10-02 19:55:49	2003-04-07 12:59:11	9	14	342	0	935	1629	226	236.20	25	61.05	CHANGED	hp.D.hhGlhLAlSSSlFIGuSFIlKKKGLh+hut.uuhRAupGGauYLpEhlWWuGhloMhlGEsANFAAYAFAPAsLVTPLGALSlllSAlluphhLpE+LphhGhlGChLsIlGSsllVlHAPpEppltSlpplhphhs-PuFllashhllssslhLlhhhtP+hGpppllVYIslCSlhGuLoVhSVKAlGIAIK.ohs.Gts.ltashsWlhlllhlhClshQlNYLN+ALDhFNsulVoPlYYVhFTT.slhsShIhFK-Wts.shsslhspLsGFhTllsGsFLLHsh+Dhs.sp	..............................................................................h.......Gh.lsh..u......shh...u..uh.....l..p......+...h..............u..h.h...p..t............t..............................t......s........h.....s.Y...h.....pp.h.....W..W.....h.G.h...h.........h..................h..........h.l.G..p....h.ss....F...s....AY....uF.......A....P.........s.lV..................sP..L..G.u.lu.l.....l...h..........s......slluthhL.p...E..plp........h..hs........h.......l........G.........s.h..lslh.G.s.s.l.l.....l....h...h.....u......s......p.p...p...t..h...........s...hp......ph.......t.h.h.h...p...........................s.....F.l..ha.h.h....h..........h........hh......h......h...h..........h...........hh......h......h...........t.................................t...................s.......t.........p...........p........h............h.....l........h..l.....ls.....u......h...................h.G..u....h....o....lh...ss....K.u.....lu.hhl.t.....h.t.....s............h..............h..a.h..h...h...h..hh.h..h..s.h..................hh..Qh..alNcuL...p.......hass..sh.......l.Ph...halhaT.....sl...hs.....u....hlhapt.a.t...s....p............hh..h..hhG..hhhh.h.Glhll.p.........t..........................................................................................................................................................	0	287	502	740
+5483	PF05655	AvrD	Pseudomon_AvrD; 	Pseudomonas avirulence D protein (AvrD)	Moxon SJ	anon	Pfam-B_9946 (release 8.0)	Family	This family consists of several avirulence D (AvrD) proteins primarily found in Pseudomonas syringae [1,2].	25.00	25.00	59.70	33.70	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.06	0.70	-5.55	3	71	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	50	0	13	69	0	260.20	35	96.63	CHANGED	MQDLSFSoIENHLGPAKDRFFGDGFKHVEYSARHVNLTESA..VcAoIoLSYPANWSKKNcSuELlPHLSSIDALTISlNLSQDILLNcFKSID.....HCWVRRISIKAGsKPEEDLR-INA..KITKESQGLDSpGDThLIFGGNVGTMTVQLEFIIPAAHEI-TlKDS..............oEKSCYSLHFKNRTQFIDDIIFYSPLN.AIS+LFVAaDsE.PNFLPGGIEANYPNIlNPVDSLVSHAQIAQALLYKLDGLTR-ESNTLWMRsLNIIAENPAKRpAATRLLVTELKRANIVSlKGcNWRVAEVAGHMNGIThSSSVAHLLPL	.................................tsl-phLGstcpRaFGpGa+psphphpph....thstpt.....hpu.ho....l..sYPu.sWScKsss.-lhPHLSoIDAlhlusplup....tllh...p..ph....p.u.l-.......psa.l++loI+AGpcP....E.DLp..s..l..s..A..plsppt.s.ps..ss..t..hhFt.spl.usMplplph..hh...s.....t...cph.....t.shpss..............sp.cphao.ta+s.......+pphlpclhh..ss.hs..shu.p.lhh...t.stt.sph....Ghpu.s.a.s...shhs.lDsLlshAQluQsLlY+LDslsRspSsTLWMRplsl..h..spp.....Ph...t..ht..t.t..lhs....ph.csphl.phtsppWR...sph...s..........s..t...hphpsplAH.L.........................................	0	1	8	13
+5484	PF05656	DUF805		Protein of unknown function (DUF805)	Moxon SJ	anon	Pfam-B_2800 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	26.80	26.80	26.90	26.80	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.91	0.71	-4.28	159	3368	2009-01-15 18:05:59	2003-04-07 12:59:11	9	20	1884	0	465	1828	801	123.10	28	77.08	CHANGED	pahsFpGRusRp-aW.hhhLh.hllhhh......hh.hlshhh........................................thhshlhhlhhl...shhl.......Ps....lA...lsl..RRLHDhs.+SGW...................ahLl.................................................hhl...........P.hlGh............................................lh...hll....hh.h................h.u...p.s......sNp.aGssPts	......................................................................hhsFpGRspRp-.a........W..hhhL.h...h.l.h.h.h.l....lh..hlthhh......................................................hhh.sll...s.h.l.a.s.l....h...shl..........Ps...........hA.......lslRRLHDps..+SGa...................Whll.........................................................................................................hhl....P..hlsh..........................................................lh....llh....hh.s................hs.u...sss..tN+.aG.ss..h............................................................	0	122	259	367
+5485	PF05657	DUF806		Protein of unknown function (DUF806)	Moxon SJ	anon	Pfam-B_7291 (release 8.0)	Family	This family consists of several Siphovirus and Lactococcus proteins of unknown function. The viral sequences are thought to be tail component proteins.	25.00	25.00	26.30	26.10	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.51	0.71	-4.09	9	73	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	68	0	13	71	1	122.90	31	97.19	CHANGED	hpPsppsppllpshshshlDpVYhssIPcEhlsNsspThVLlTEstssPspauNssFpuhshGVElQIFYphsls.pDhp..ssEIpLh+thpcscWplssS+sHhhDPDTs....QhpKshYhs+sh.I	...........................hPl.pltpllpshshshlD..plahsslPpEhh..cssspThlLl..TEssss.stauNssFpshshsVElQIFYppshs.pDhp.......phElpLh+hhpsscWhlss.u.+sHshDPDTp....Qlppshahs+sh...........	0	4	7	10
+5486	PF05658	YadA_head	Hep_Hag;	Head domain of trimeric autotransporter adhesin	Yeats C	anon	Yeats C	Repeat	This seven residue repeat makes up the majority sequence of a family of bacterial haemagglutinins and invasins. The representative alignment contains four repeats.	20.20	20.20	20.30	20.20	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.39	0.73	-7.61	0.73	-3.49	239	9521	2012-09-20 11:56:39	2003-04-07 12:59:11	9	620	916	22	1068	8054	662	27.80	37	11.89	CHANGED	AsGpsusAlGssupA..sussosAlGssup	.............AsGpsSlAlGssutA...sussSlAlGsso................	0	242	496	794
+5487	PF05659	RPW8		Arabidopsis broad-spectrum mildew resistance protein RPW8	Moxon SJ	anon	Pfam-B_7373 (release 8.0)	Family	This family consists of several broad-spectrum mildew resistance proteins from Arabidopsis thaliana. Plant disease resistance (R) genes control the recognition of specific pathogens and activate subsequent defence responses. The Arabidopsis thaliana locus Resistance To Powdery Mildew 8 (RPW8) contains two naturally polymorphic, dominant R genes, RPW8.1 and RPW8.2, which individually control resistance to a broad range of powdery mildew pathogens. They induce localised, salicylic acid-dependent defences similar to those induced by R genes that control specific resistance. Apparently, broad-spectrum resistance mediated by RPW8 uses the same mechanisms as specific resistance [1,2].	24.00	24.00	24.10	25.10	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.75	0.71	-4.66	10	146	2009-09-21 12:32:58	2003-04-07 12:59:11	6	17	20	0	59	159	0	131.50	27	27.49	CHANGED	PluElhs.........GAALGluLQlLa-Alp+AKD+ShTT+sILcRLcATIpcIoPllscIDKlScch--s..R+VlEcLK+LLEcAssLVEsYAELR.RRNllKKaRYpR+IKELEuuL+WhlDVDlQVsQWsDIKELhAKMSEMsTK.....LDcItsQP	.....................................clhs.........GusLGhsht.Lh....cslhcspc+uhph+shlc+LpsTlcsIpPhlhc.Icphs..pchsps...pc.hccLpphLccuhpLlcphsclp.phshh.++hp.Y...tp+lcpl-tplthhhpsplplp.htDlpclhsthtt.............................................................	0	11	45	49
+5488	PF05660	DUF807		Coxiella burnetii protein of unknown function (DUF807)	Moxon SJ	anon	Pfam-B_7114 (release 8.0)	Family	This family consists of several proteins of unknown function from Coxiella burnetii (the causative agent of a zoonotic disease called Q fever).	25.00	25.00	112.70	111.80	21.70	16.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.61	0.71	-4.52	4	23	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	2	11	0	138.40	57	59.30	CHANGED	MLtApLhF.GphslGPI.PcSYFGNsGAI.sPcIc.KlATGcYTIThLSuRslppTQPulVHIslhD-sNtsFCsRlsKulpFTYcPpNo-.FPWKhhhpIAlpEt-hhtIcpKp....l.VTh+hhpcupGslVssGhhptcshhNV	.......MLtApLhF.GphslGPI.PcSYFGNsGAI.sPcIp.KhATGcYTIThLouRslppTQPssVHIsh.D-sNtsFCsRlsKslpFTYcPpNSp.FPWKhhhpIAlpcGDGohhDsp.....VMlThthtNpsstAlhssshsRspAclNs	0	2	2	2
+5489	PF05661	DUF808		Protein of unknown function (DUF808)	Moxon SJ	anon	Pfam-B_7112 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	25.00	25.00	35.80	26.10	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.88	0.70	-5.59	47	1348	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	1301	0	257	880	93	282.80	53	95.12	CHANGED	MAGuSLLsLLDDIAolLDDVAlMTKlAAK..................KTAGVLGDDLALNAQQVoG..VpA-RELPVVWAVAKGShhNKhILVPAALLISAalPW.........lITPLLMlGGhaLCFEGhEKlhHKahHp..........p.cppptpuhscss........hDLsAaEK-KIKGAIRTDFILSAEIIsIsLGoVustshhsQlhVLusIAllMTlGVYGLVAGIVKLDDhGLaL.p+sus.....htctlGtuLLssAPhLMKsLoVlGThAMFLVGGGILsHGlPslHHh...lc.hstth.......ussluslsPsllNullGllAGulllhll	...........hAhuSLLsLLDDI.......Aol.......L.......DDlulMuKlAAK..............KTAGVLGDDLALNAQQVoG..VpAsRELPVVWuVAKGSLlNK.l.I.L.V.PhALlISAFhPW.........hITPLLMlGGua.....LCFEGsEKllHhh.s+....cc...........pp...p...pph.t.ss.............tDshthEKcKlKGAIRTDFILSAEIlsIoL.GhV..u...p.........s..s....lhsQllVLusIAlllTlGVYGLVulIVKlDDlGhaLs...c...+uus........................hhpulG+GLlhhAPhLMKsLSlVGTlAMFLVGGGIl...V........H.G.....l........s.....s........L........H.....H.h.............lEchst.t..t................uuhluhll.ssllshllGhlhGulllh........................................	0	55	142	209
+5490	PF05662	YadA_stalk	HIM;	Coiled stalk of trimeric autotransporter adhesin	Yeats C	anon	Yeats C	Motif	This short motif is found in invasins and haemagglutinins, normally associated with (Pfam:PF05658).	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.52	0.73	-6.66	0.73	-3.98	75	6882	2009-01-15 18:05:59	2003-04-07 12:59:11	9	631	823	15	787	5827	118	22.40	61	6.44	CHANGED	ppIoNVAsG...ssuTDAVNsuQL	...ppITNVAuG....ssuTDAVNsuQL..	0	128	332	567
+5491	PF05663	DUF809		Protein of unknown function (DUF809)	Moxon SJ	anon	Pfam-B_7264 (release 8.0)	Family	This family consists of several proteins of unknown function Raphanus sativus (Radish) and Brassica napus (Rape).	25.00	25.00	107.20	104.70	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.18	0.71	-4.25	4	16	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	11	0	131.20	97	99.95	CHANGED	MITFFEKLSTFCHNLTPTECKVSVISFFLLAFLLMAHIWLSWFSNNQHCLRTMRHLEKLKIPYEFQYGWLGVKITIKSNVPNDEVTKKVSPIIKGEIEGKEEKKEGKGEIEGKEEKKEGKGEIEGKEEKKEVENGPRK	...MITFFEKLSTFCHNLTPTECKVSVISFFLLAFLLMAHIWLSWFSNNQHCLRTMRHLEKLKIPYEFQYGWLGVKITIKSNVPNDEVTKKVSPIIKGEIEGKEEKKEGKGEIEGKEEKKEGKGEIEGKEEKKEVENGPRK....	0	0	0	0
+5492	PF05664	DUF810		Protein of unknown function (DUF810)	Moxon SJ	anon	Pfam-B_5709 (release 8.0)	Family	This family consists of several plant proteins of unknown function.	19.20	19.20	19.40	19.30	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	677	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-13.12	0.70	-6.25	10	230	2009-01-15 18:05:59	2003-04-07 12:59:11	6	14	75	0	160	222	1	430.80	22	48.43	CHANGED	uLocsDLRETAYEIllAustuS.....tshhh...pthtppc..................................S+sKhhLuL+tpt....................................ttssupst+sc+shohsElMRhQMcloEphDsRlR+sLL+hssuplG+RhEsllLPLELLpplps.o-FsD..cEYcpWQ+RpL+lLEtGLlh+PslshscosppspcLRpll+s.....uhspslsouppoEsh+oLRpsshSLutR.upsGh...su-sCHWADGYP..LNl+LYptLLpusFD.hD-ssll-El-EllELlK+TWssLGIs.cslHslCaAWsLFpQaVhTu..E.tLLtsAhstLt-VutDtp.ssp-slYlK................hLsSsLSulhuWu-K+LhDYHcoF......scssl......sh-slVoluhssu+lLuEDsspth+cptt.........ss+-+l-pYIRSSl+sAFsc...........cuphtts+uspssttsLA.LAc-ss-LAhpEpphFSPlLppWHP.usGVuAupLHpsYGscL+paLuuhscLT.DsVpVl.uAscLEpsLVphh...usss.-DGGculh+.ch.PaElEshhusLVhsWlpt+l-clpphV-RshppEsWcPtSs.cpsaAsSAVElhRllcETl-tFFtL.IPh+sshLpsLscGlDpuhQpYsspshuuhGu+pshlPslPsLTRhpcsotlhshhKKchhssstscc+tspth..............shslspLCVRLNTLcalhocLcsLE+	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................................................................h............Pa..........ph....-phhhsh...lhpWlptp.pph..phlppshpp.....-.....p.......a.....p...sh........s.............t........p........p.taus.Ssl-lh+hhpp..............sl-th.h.tl........h...s.......c.......t...h...h....sLhpuls.....thht......Yhphh.....t.th....s...s....c..p..p.hh.P..h.s..LoR.ppt...h.....hh.+ct..............p................................................hh.p.hl+lNslpahhpplp.l-.................................................................................................................	0	27	89	125
+5494	PF05666	Fels1		Fels-1 Prophage Protein-like	Yeats C	anon	Yeats C	Family	\N	25.00	25.00	47.40	26.90	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.27	0.72	-4.59	12	669	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	339	0	28	193	6	49.60	50	79.54	CHANGED	sAhA..spssslhoPusGVlCDph..lCtD..........StGlShslTccYhGp+	.............u.ts.ssu..o.AsGVhCDsh..lChs..........S.stIs.phT+hhhhp+....................	0	4	10	19
+5495	PF05667	DUF812		Protein of unknown function (DUF812)	Moxon SJ	anon	Pfam-B_7417 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function.	30.00	30.00	31.60	31.20	29.40	27.80	hmmbuild  -o /dev/null HMM SEED	594	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.71	0.70	-6.01	10	190	2009-09-10 22:47:38	2003-04-07 12:59:11	6	4	106	0	126	188	1	373.50	26	88.19	CHANGED	M..-ElDpIIlHoLRQlGs-lsE-lpuLcsF..........ToshlVcsVs+CLplIsPsl..sLP+oLP.s.....uMApRFpluopLApACp-lG..YRu-IGYQTFLYsNss-lRpllMFLlEpLPR-p.suscus...pPlu.............psstLccpIspsLppQLp...............hPWlPphsR.............h...s..shptFpsp.hsl..sspsp.tt.ssthpphapp.hl.slo......tslssolLpsssuplshsschch-a.utsh......E-hcpcKppplpp+ltshhppstt....s......suucpls-llpp.t.t.........s..hspppt..........spphuss.usssssshssEcstpppcps-L-uLpppIcclpsplpphpsch+phpuplpplp-phpstcppssclEpphKlKc+TstLLsDsEsNl....sKLpullsuoup+hhpLssQWEs+RsPLl-phcpL+thpppp.scoppphccIcslRpcIcclspElpsKsphappL.spaEshs+s.VsRouYTcRILEIIuNI+KQKp-IsKILsDTRsLQKEINsloupL-RTFsVTD-LlF+-AK..+DEtsK+AYKhLAsLHssCs-LlcsV--TGslpREIRDLEcQI-sEct+s	......................................................................................................................................................t.....h.........p....l.th..........sst.hhphh.thl..lp........t........ths......h.P.........shst+hphs.tluphh....p..G..h...phua......p............p..hLYss...p.....h+tl..hhhLhppL.stt...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ht..h......h.t..t.ht..t.h......t.h..p...t.t.t...........p....tt.ht.h.tph..h.h.ps.t.....h......pLp.hhtttttph.plttpWp...thch....h.tphpthp...........ttp..h....tplp.hctphpth..chtt+pp.hppL.t.........phpphspt..h......s.......R..YhpRIhEhhtsl+KQct-I.+lh.-s+.lQpphs.httplpRpashs--hlappu+........p-...........h+.....psY+.Lstlct.httlhthl..hs.h.pphh....chp.pl...........................................................................................	0	48	64	98
+5497	PF05669	Med31	SOH1; 	SOH1	Moxon SJ	anon	Pfam-B_7443 (release 8.0)	Family	The family consists of Saccharomyces cerevisiae SOH1 homologues. SOH1 is responsible for the repression of temperature sensitive growth of the HPR1 mutant [1] and has been found to be a component of the RNA polymerase II transcription complex. SOH1 not only interacts with factors involved in DNA repair, but transcription as well. Thus, the SOH1 protein may serve to couple these two processes [2]. 	25.00	25.00	25.00	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.63	0.72	-4.29	34	308	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	274	4	217	302	0	103.10	44	60.92	CHANGED	sshsRFplELEFVQsLANPpYlpaLA...pp.........pYa..................p-.pFlsYL+YL.pYW+cPcYu+alhYP.pCLahLc.lLpsppFRpslsssss....hphl....pphhhpattht.pthph	.......t.phRFplELEFVQsLANPpYL.s.............aLA...Qp...................tah.................................c-psFlsYL+YL.pYW+..cP-Yu+aLpYP.tCLahL-.LL.Qp.-.pF...Rptlsssps......hch.l..tppthhtW.tht.....t.........................................	0	73	119	181
+5498	PF05670	DUF814		Domain of unknown function (DUF814)	Bateman A	anon	Pfam-B_738 (Release 8.0)	Domain	This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity [1].  Hence the activity of this C-terminal domain is unknown. This domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.88	0.72	-4.10	39	2812	2009-09-13 15:36:20	2003-04-07 12:59:11	8	19	2349	0	939	2335	311	89.80	31	16.57	CHANGED	ahhoss.ahllsG+ssppN-hL.sh+hhcppDlahHscthsuuHVll+spstps.p........slp-AAphAstaS+.h+tuspssssY...........sphcalpK	............h...sssshhIhVG+NshQN-.L..sh...K..h..Acp..s.D...l..W.......h....Hs+.cl.PGSH.Vl..l+s..s..t..s.s.s.p.............................slp-A....ApLAuh..aS...........c...ucpu......sp.lsVca...............sth+pl+K...............................................	0	362	602	811
+5499	PF05671	GETHR		GETHR pentapeptide repeat (5 copies)	Bateman A	anon	Pfam-B_8059 (release 8.0)	Repeat	This pentapeptide repeat is found mainly in C. elegans.  The most conserved amino acid at each position leads to its name GETHR (Bateman A unpublished obs.). The family also includes a divergent repeat in a microneme protein Swiss:Q26588.  The function of this repeat is unknown.	21.50	21.50	21.90	21.70	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.12	0.72	-4.80	3	9	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	3	0	9	25	4	23.90	70	46.64	CHANGED	GETHRGETHRGETRRGETHRGET+R	....shRGET+RGET+RGET+RGET+p.	0	6	6	9
+5500	PF05672	MAP7	E-MAP-115; 	MAP7 (E-MAP-115) family	Bateman A	anon	Pfam-B_8157 (release 8.0)	Family	The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin [1]. The binding of this microtubule associated protein is nucleotide independent [2].	28.50	28.50	29.00	29.00	28.10	28.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.28	0.71	-11.64	0.71	-4.87	3	338	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	64	0	136	296	0	159.00	47	22.95	CHANGED	APuussNuuAsuKPoAGTTDsEEATRLLAEKRRQAREQRE+EEQERREQEEpDRpcREELtpRsAEER.sRREEEARRpEEEcAREKEEp..............hpRpAEEc....thpEQEEQER..lQKQKEEAEARuREEAERhRLEREKHFQQpEQERLERKKRLEEIMKRTRKSEVS-phKKpDsKs	................................................sssssK.ssAGTTDsEEAs+lLAE.KRR.AREQ+E+..E...EpE.R.......h...c...pE.....Ep.-.........R......t....t.....+.......E.E..t......p+.h...tE..E...............R.t+......pE.-E.uR+.h.E.-....c.......pt.R.c..c.tcp................................t.t..tcEc...........tppEp...EE..pE+..........lp+QKEEAEu+..u+EEAE+.RhEREchhppp.EQE....RhERKK....RlEEIMKRTR+...o-s...stp.pt.............................................................................	0	13	29	65
+5501	PF05673	DUF815		Protein of unknown function (DUF815)	Moxon SJ	anon	Pfam-B_6403 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.51	0.70	-5.45	75	1159	2012-10-05 12:31:08	2003-04-07 12:59:11	8	7	1089	0	330	2454	848	243.70	43	76.12	CHANGED	spshAapWc......s..uh.Lpsl.............ppscslpLspLhGl-cQ+ctLlcNTcpFlpGhPANNlLLaGuRGTGKSSLVKAllspasspG..........LRLIEls+-DLtsLPpllshl+....spP.p+FIlFsDDLSFEps-ssY......KsLKulL-GulpupPsNVllYATSNRRHLlPEhhsDsts........ssElHss-ulEEKlSLSDRFGLhLuFashsQ-pYLplVcpas.............pph....ulshst...........cpLcpcAlpWuhp+GuRSGRsAhQFhpclsGch	.....................................................................................s.shAFhWp.........stpsh..LpPl.............tp..ss.t.lpLscLhGl-p.Q+.c....t......L.......h...c.......N...T.......c.........p.....F.....l..p...G.........h.........P.........A...........N..N.........s..L.L.aGuRGTGK.SSLlKA.ll.spats.pG.........................L...R..L.....l...E.....l....p..+.....c..D...L.........t...s.....L....s....c.......l..l....s....h....l...+...................p.p....s........+....F.....I.l.F...CD.......D....L.............S.......F..........Ec...s.-.s...sY...............K....s.....LK..u....l...L....-..G...u..l.p.s........p.P.s....N...VllY..AT.SN.RR.HLlsEphp-Nps.........ssElHsu-u.lEEKl.S..LSDR...FGLWLuFashsQccYLphVctah...........................pch......slshsp..............-pl+tcAl.pWuhpRGuRSGRsAhQFhpphtGp.h.............................................................................................	1	102	225	279
+5502	PF05674	DUF816		Baculovirus protein of unknown function (DUF816)	Bateman A	anon	Pfam-B_7178 (release 8.0)	Family	This family includes proteins that are about 200 amino acids in length.  The proteins are all from baculoviruses. This family includes ORF107 from Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) and a variety of other numbered ORF proteins, such as ORF52 Swiss:Q91F03, ORF140 Swiss:Q9YMI8. The function of these proteins is unknown.	24.60	24.60	31.80	31.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.96	0.71	-4.54	14	62	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	58	0	0	57	0	161.60	54	71.62	CHANGED	olDVD-Fu+QLIADKCssLIEsppMLPtslLullKpA+c-YhcsPoscNYpplK+LhsQTKYV--SI-YKNFNRtlhLIAhphhlNKu+-hFssY..Kshl-sshKRLppINPDlKSSP+AMLpHYpECL-....ph-sP+.tD-HHLloFuKEIhTKIFl-slc.ho.sNpuslshs	..lslDsFA+QLIsDKCSsLIEspshLPsNlLsIlKpARDcYFcsPosKNY-.lKKLh.pTKYhDDSIDYKsFNRRlLLIuhKhuLNKupsaFssY..KsllEsAlKRLspINPDlKSSP+AMLQHYpECLE....NlDsP+.sDEHHLlTFuKEIATKIFl-sl-.aSa.sNpSslph.p...	0	0	0	0
+5503	PF05675	DUF817		Protein of unknown function (DUF817)	Moxon SJ	anon	Pfam-B_7331 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function.	25.90	25.90	49.70	49.70	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.60	0.70	-4.96	39	378	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	367	0	80	340	18	223.70	50	85.60	CHANGED	phlhFshKQAhuCLFssllhhsLhlT.+ll..shssLsRYDhLLIhsLlhQhhhltotLEThDElKVIhlFHllGhsLElFKlp..hG..SWSYPEtuhhKlhGVPLaSGFMYASVuSYIspAWRha-lchtpaPshahsssLushIYhNFFTHHalhDhRWhLhshshllFhRTaVhFplpssph+MPLlLuFhLIuFFIWlAENIuTFauAWpYPsQtcuWphVcluKloSWaLLlIISh	...............phhhFshcQAhuCLFssllFlsLhlophh....shsslhRYDhLLIhsLlhQhhhlthtLEThDElKVIslFHllGhsLElaKsc..hG..SWuYP..-tuh.KlhGVPLaSGFMYAuVuSYIsQAWRhhclchppaPshhhshsLushIYhNFFTHHalhDhRWhLhshhhllFh+ThVhFpltst.p..h+MPLlLuFhLIuFFIWlAENIuTFaGAWpYPsQhpuWphVHluKloSWaLLVllSh..................	0	23	47	64
+5504	PF05676	NDUF_B7	NDUFB7; 	NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)	Moxon SJ	anon	Pfam-B_7077 (release 8.0)	Family	This family consists of several NADH-ubiquinone oxidoreductase B18 subunit proteins from different eukaryotic organisms. Oxidative phosphorylation is the well-characterised process in which ATP, the principal carrier of chemical energy of individual cells, is produced due to a mitochondrial proton gradient formed by the transfer of electrons from NADH and FADH2 to molecular oxygen. The oxidative phosphorylation (OXPHOS) system is located in the mitochondrial inner membrane and consists of five multi-subunit enzyme complexes and two small electron carriers: coenzyme Q10 and cytochrome C. At least 70 structural proteins involved in the formation of the whole OXPHOS system are encoded by nuclear genes, whereas 13 structural proteins are encoded by the mitochondrial genome. Deficiency of NADH ubiquinone oxidoreductase, the first enzyme complex of the mitochondrial respiratory chain, is one of the most frequent causes of human mitochondrial encephalomyopathies [1].	21.90	21.90	22.50	22.00	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.52	0.72	-4.56	14	256	2012-10-02 15:44:21	2003-04-07 12:59:11	8	6	227	0	183	245	2	65.10	43	53.76	CHANGED	.MlATpEEMptA+LPLt.RDaCAHhLIsLp+CRp-pa.hs.atCccERHsY-pCpY-DalhRhKch-	...........hATpcEMppA+lPLthRDhCAHhLIsLp+C.R.pcp.a.hs...a...pCccERHsY-cCp.Yc-ahhRhtch-............	0	62	102	150
+5505	PF05677	DUF818		Chlamydia CHLPS protein (DUF818)	Moxon SJ	anon	Pfam-B_7510 (release 8.0)	Family	This family consists of several Chlamydia CHLPS proteins, the function of which are unknown.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.21	0.70	-5.72	5	50	2012-10-03 11:45:05	2003-04-07 12:59:11	7	2	27	0	22	183	59	298.60	28	74.67	CHANGED	soILcocP+PplshFSSc+A+puaE+RctHPlLaKILslIhcIlKhLIGLIlFlPLGLaWVLQKlCQNsILPuuuhLhop.phChc....splL+psFlspLcshhppscVSSs+RVsIQpD-LlIDoLuI+lPsAcPcRWMLISLGNS-sLEshshlttcc-...SlpclAKtsGANILVFNYPGVMSSpGsloRENLuKAYQACVRYLRD+.sGPpA+QIIAYGYSLGulVQAtALsKElsDGSDuToWlVVKDRGPRSluAlAsQahGsIGshlAsLsGWsIcSsKpSc-LsCPEIFIYusDp.cssLIGD.GLFp+EsClAsPFL-sPpl.chsGsKIPIuEpsLpHpsPLccsTIpcLAssIlc+LS	.....................................................................................................................................................hthhKhlh.hhh..P.slha.h..hs.t..lhst....h............pphhp..a.h.tthpt...h.ppt.h..s...phpRlsIp.t..D.plhlDsht.l.p.h.s.....p....A....+ss.R.W.hLhuhGNupsaEp..hh....s....lhplAKp...h.....p..uNlllFNYPGVhpS........pGps..s.p.c.s.LspuapAsV.+.YLcDp..pGspAcpIlsYGaSLGu...u..Vp...A..t.ALppp.hp..sp-shpahhlKDRu.pSlushA....pp..........hh...s.......l.s..thhhp....lh...sWphs....u.K.ucpL...s...-l..hh.......hth......s............t....p........l.tc.thh..p.shAt.hhp.........pK..l......c.t.l..................................................................................................	0	12	12	20
+5506	PF05678	VQ		VQ motif	Bateman A	anon	Pfam-B_7960 (release 8.0)	Motif	This short motif is found in a variety of plant proteins. These proteins vary greatly in length and are mostly composed of low complexity regions. They all conserve a short motif FXhVQChTG, where X is any amino acid and h is a hydrophobic amino acid. The function of this motif is uncertain, however one protein in this family has been found to bind the SigA sigma factor Swiss:Q9LDH1. It would seem plausible that this motif is needed for this activity and that this whole family might be involved in modulating plastid sigma factors (Bateman A pers. obs.).	20.40	20.40	20.60	20.90	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-7.23	0.72	-4.91	49	612	2009-09-11 20:58:54	2003-04-07 12:59:11	9	6	26	0	403	538	0	30.40	35	13.43	CHANGED	thhsspllps-sssF+slVQcLTGtssssss	.............hssphlp.s-.ss.sFRslVQcLT.Gtssss..........	0	56	239	327
+5507	PF05679	CHGN		Chondroitin N-acetylgalactosaminyltransferase	Bateman A	anon	Pfam-B_8249 (release 8.0)	Family	\N	19.70	19.70	20.40	19.90	18.90	18.30	hmmbuild  -o /dev/null HMM SEED	499	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.70	0.70	-5.79	13	643	2012-10-03 05:28:31	2003-04-07 12:59:11	11	14	100	0	386	631	1	400.30	22	63.56	CHANGED	HlssCl+shhSs+cD.VplGRCVpchuGl.sCshsa..Qulhacsaphs........hcuastph+scph+sAlTlHPlpsPshhYRLHsYhtpl+lpchppcphtLcp-ltphoph.tsps.tpsphP....................LGlsPs...hpPpsRp-llpW-als..+phh.uscss.P+pplcusp+p-lsDllspsh-plNpptp....sl-F..+pLhhGYRRhDsh+GhDYhLDL........Lhh++tRG++............hsVpR+hal.+shoc...................................................lEll.sssasscu............oRlslllPLsu+..sshhh+FlcsaEpsCLcs..ppsstLhllhahcss-spphsp.......pplhppLcs+a..ssu+lsalslp......................ssshSpslAlDlAs+..+hsh-oLlhlssschsFps-FLsRsRhNTIpGhQlahPIsFspYcPch.........................tp...psstsss.hclspss..........GaFcchuaulsuhYpuDhlpuchthhsp...................chps.GlEslclh-hhlpss.p...................................l+VhRusEPuLVa........la+slsCD.ssL-ptphchChsoKsps....luSpcpL	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................th......a...h...........h...........t.......pp.........lp....t........p...t..tl....-...s.lt.tshc.lNpp.p..................hh.ph.....pc.l.hp..G..h...hRh-.h+......GhcYh.Lch.........h...hptp......p................................h..h+..+.h..l..hp.s.hu.t...............................................................................................................l.hl...s....h.....htp........................................shlplllP......ltsp..hc.hh.pFhps.atph..shps....pppshLhllhhhp...p.pt.h.tp............thh.tphp..p.ch......shtphphl..tlp............................t..thscstuLp.hu.sc........th...s...s.c.s..LhFhsDl.chhhsschLpps....Rhps.....l.GhpsaaPlhFppasPth...................................................t................tt....sh.ppts.............G.aacp.uaGhsshYpuDahph...tth.s.........................phptWGhED.h..c..lhcthlpss...........................................LclhRs...ulhp..............ha.+..h.C.........s......p..hs.t..hphCh.sth.t......uuh..................................................................	0	115	143	250
+5508	PF05680	ATP-synt_E		ATP synthase E chain	Moxon SJ	anon	Pfam-B_6116 (release 8.0)	Family	This family consists of several ATP synthase E chain sequences which are components of the CF(0) subunit [1].	21.00	21.00	21.00	21.20	20.10	20.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.10	0.72	-4.03	17	264	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	228	0	172	254	0	78.20	28	86.96	CHANGED	hss...SPhlpssRaSALshGlsYGhh+hppLp...cpcpct+chctppthltptKht.tK++pscpc..hpthspuop.....................shht	..........h......SshlplhRaSALshGlhYGhh+.ptLp...cptptp+chctcpphlppsKtthtKpht..t..................................st.t..................................	0	50	90	135
+5509	PF05681	Fumerase		Fumarate hydratase (Fumerase)	Moxon SJ	anon	Pfam-B_2085 (release 8.0)	Family	This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre [1].	25.00	25.00	25.70	25.50	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.63	0.70	-5.32	170	3534	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	2307	0	710	2256	603	274.30	41	60.95	CHANGED	ltcsltchhpcsshhLssDhhpulpcAhcpEcush.u+tsltplLcNuclAspt..........phPlCQDTGhssl.FlclGp.pVphss...slp-slscGVccuYp..-ssLRhShVtc.Ph.pRpNTsc....N....sPAllchchl................sG...-plclphhsKGG..GSENhotl.....thL........sPup...ultcaVl-sltphGss..sCPPhhlGlGIGGTs-cAshLAK+.ALh+.lsptp..s..........chtcLEpElh-plNpLGIGsQGhGGpsTsLsV+lpphP...sHsAShP.VAlslsCtAs.R+sphpl	.................................p.hstpAhpcsSahL.ssahppltp....hh.cc..c..........ust....sKhlhhphLcNuclAAcs..........hhPhCQDTGhsh.l.hsKhGpcVhhsG..........s.cpslscGVhpuYh..-ssLRhStss..s.shhcchNTGs..........N....h.PA..lch.h.V........................................................sG.....Dc..hchhshsKGG..GStNKohh................shL........sPu............slts.all-p.h.po....hGsu..ACPPh.hlulsIGGTutcsslhstK.A.h+..lDph..sstt.............u...+shcLEpELh-psppLGlGAQ.hGGphhshDl+lhphP....RHuAShP.VuhsluCu.As.Rph+hpl....................................	0	239	456	591
+5511	PF05683	Fumerase_C		Fumarase C-terminus	Moxon SJ	anon	Pfam-B_2085 (release 8.0)	Family	This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth [1].	21.80	21.80	22.00	35.20	20.10	21.70	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.30	0.71	-5.19	72	3515	2009-09-10 16:06:45	2003-04-07 12:59:11	7	8	2299	1	713	2175	505	198.00	43	47.11	CHANGED	GoGsspLpsPs...lcpaPcl.shcss...sss..............................+R..VsLss..lTc..--lppacsG-sLLLoGcllTGRDAAHK+lh-h.lspGEsLP..VDhcs+hIYYVGPV...DsltcEsVGPAGPTTuTRMDpaTcphLcpsGLhuMIGKuERGstsl-AI+cHtusYLhAlGG.AAaLlu+uIKpucVVuFt.-LGM.EAIacF-VcDM.PVoVAVDscGsulHppuPtp	..............................................................G.h.t.Lp........hp.hPt......t.........tps.................................hclsLsp.Phpc....ppL.sph.luspl.LoGsIls.uRD.h.AHt+ltEh...l....p.p.......G......c..s......LP...............l..+..s..+sI..YYAGPs.............css..s..shssGS......hG..PTTusRMD.s.a.sc.p.h..sp.sGshlMluKGsR.u.p.p.sp.-A.C.+KHsuhYLsulG.G.AAsLuppsIKcl.E.sV.tas.ELGM.EAIWcl-V-DF.PshlhlDs+GNshapph..p..................	0	244	461	596
+5512	PF05684	DUF819		Protein of unknown function (DUF819)	Moxon SJ	anon	Pfam-B_9034 (release 8.0)	Family	This family contains proteins of unknown function from archaeal, bacterial and plant species.	20.70	20.70	21.60	21.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.95	0.70	-5.64	6	548	2012-10-02 17:06:44	2003-04-07 12:59:11	7	5	422	0	194	501	310	333.30	25	86.51	CHANGED	uhLhuhuAhslWs...Ec+sKht..usVsuhllshLluhhhsslGLl...sspossasslhshLLPtsI.LLLhpsDLR+Il+.us+LLhhFLluSluhhlGsllAahlhp.h....lusDsW+hsAALhGSaIGGusNhlAhpssLsVssoshusulssDslhhulahhlLhhLsuht...pttshA-TsplpussschspspspEc+psss.schhhhlulShhlsuluthlushh.......h.hul.....susshsslhusslsLlhuFsshhsh..PuupcluplLlYshhsllGususlhslls.APhlhLauhhhlhsHlslhLulGKLF+l-LphlhlASpANIGGPsoAsshAsAhs.suLlssGlLhGlhGhulGTalGlhhG.hlpph	.............................................................hlhh.hhuhhhhh.......p..p.....hh.h.t.......thlsuhl.hhhhhshlhsshs.lh........................................................t..s....ha..h.h.phllPhsl.lhhh..phDl+.........t.l.hp......u..s.+hlhhFhhu.shuh.hl.....G...s...l..uh...hl...h.t.h..................h....s.c........h........h.........p..h....h..us....lsuS.al.....GG.usNhsAht.p.......h..h...t......s..s..s.....s....h.....huhhlssDslhhslahhhL...hhhss...h...t....h...h...p..t...h..ht.s...c.t.pt.h......p....t.....h...t.....p....p...h............t.t........t....t...............t...p............................s..hhh.hl...u..h.u...hhhs.s..lup....h....hushh...............................h..................t.ha..hllhsh...sl.u..lh.h..s..h.....sp.....h...h.ph........s..Gu.pp.lushhlY.l.hlsslGh.th.s...lt..t.l...ls...s.Ph...hh...l.h.u..h..l..h..l..hlHhh.l.hl....h...lu.+.lh+...........h..............sl.....hh.lhlASp.ANl.GGsso.A.ss......hAs....Ahp..suLsssulLhullGYslGsahGhhhu.hl...h.............................................	0	70	128	167
+5513	PF05685	Uma2	DUF820;	Putative restriction endonuclease	Moxon SJ, Bateman A	anon	Pfam-B_7809 (release 8.0) & Pfam-B_8730 (release 14.0)	Family	This family consists of hypothetical proteins that are greatly expanded in cyanobacteria.  The proteins are found sporadically in other bacteria.  A small number of member proteins also contain Pfam:PF02861 domains that are involved in protein interactions. Solutions of several structures for members of this family show that it is likely to be acting as an endonuclease.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.28	0.71	-4.90	170	4083	2012-10-11 20:44:44	2003-04-07 12:59:11	7	12	450	7	1583	4539	272	163.40	17	81.91	CHANGED	hp-a.hphs........ttth+hEh..hsGplhh..h...sshs.shHsp.hsstLhttl..t.h..hpt..ths..hshss.shshph....................tts.h.PDlshhptp.......hpphspt...................shsPslllElhSsssp...t-.htp.................KhthY.......t.thGlttaal......lD............spppp.......lplaphs..tt.......tap.hph......ttsphhph..sls.sht....lslp	..................................................................th..th.........t..t...p.h.Eh..hpGtlh.......h...........ss.s...Htt..h.ttlh.....thl.....tth.......hpt.....t.s......hhhhs..shtlth......s.............tpshhtPDlh.lhttp.........tph.pt...............................hstsPplllEll........S...s.u...sp...tDhtt.........................................K.h.t.h.Y.......t..phG.ltcYal......l-..............s.p...p...p.p...........lp.lapht....tt........tat....th........t...t..h....................t...............................................................................................	0	486	1227	1544
+5514	PF05686	Glyco_transf_90	DUF821;	Glycosyl transferase family 90	Moxon SJ	anon	Pfam-B_6682 (Release 8.0) & Pfam-B_7101 (Release 8.0)	Family	This family of glycosyl transferases are specifically (mannosyl) glucuronoxylomannan/galactoxylomannan -beta 1,2-xylosyltransferases, EC:2.4.2.-.	20.50	20.50	20.80	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.28	0.70	-5.78	19	1264	2012-10-03 16:42:30	2003-04-07 12:59:11	7	25	380	0	784	1222	143	256.40	18	53.19	CHANGED	s..ps.sCPsYFRaIccDLcPWcps.GI..oR-hlcRu..+ppAthRlsIlsG+lYlcpaccshQoRDhFThWGllQLLRcYsG+lPDlELhFsCsDhPhl+ptsap.t.......sPPPLFpYCusspolDIVFPDWSFW.GWsEl......Nl+.WshhhtclpcusscspWpcRtPhAYW+GNssVsp..Rt-Ll+Cs.hos.p.hsAclhpp............................Dhs.t.c.uh+pssl.spCpa+YpI.l-GhAhShp.KYILuCDShsLhlps.Yh-FF.+sLhPhpHYhPlcsttc..spsl+.tlpWupspsptApcIucpGSpFlpccLpM-hVYDYMaHLLsEYAKLL+aKPplPpsusElss-shsC.hp.....Gh.+phh.pSh...sssps.PCph.PsPhp..tht.hhp+ptp.h+pVcphE	.............................................................................................................................................................................t.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.......t...........t...........a.t.p.+....shh.h.....a+....G..........t.........t.............t.................................R.........t...h...h..t..h.......t..............t..........................h......t.s.thh.t.............................................................p.t.t.............hh...p........h...s....h.t-...t...h.......p.aK......Y...l..l..sl..-.........G...s.s...h.S.s..p...h...thl..htssSlsl.t......t.....s..h..........a........h......................-.....aa.....h...p...............t........L.....h.....P...h....h....H....Y..l..P...lp..p.......s.................hp-....l........p...........h....l...............p........a................h.........p..........p........p.......s.........p.....t...A...p...pIu.p.p.u..p.p.ahp............p.....lp..tt.h......Y.hhpl.h........pauph............................................................................................................tt.....................................................................................	0	263	474	641
+5515	PF05687	DUF822	DUF822; Peptidase_M15_2; 	Plant protein of unknown function (DUF822)	Moxon SJ	anon	Pfam-B_7149 (release 8.0)	Family	This family consists of the N terminal regions of several plant proteins of unknown function.	25.00	25.00	26.20	25.70	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.18	0.71	-3.85	15	154	2009-01-15 18:05:59	2003-04-07 12:59:11	8	6	22	0	105	163	0	141.80	46	37.09	CHANGED	uuusRpPTW+ERENNK+RERRRRAIAAKIauGLRApGNYsLPKHCDNNEVLKALCpEAGWlVEsDGTTYR...KGs+Ps...t.-hsGsSss..sSPsSShp..........SPhsSYpsSPsSSuFPSPoph-.hsht..........ssllPaLpshs.........ssSuhs	.........ussRhPoW+ERENNK+.RERRRRAIAAKIauGLRtaGNYpLPKHCDNNEVLKALCpEAGWsVEsDGTTYR..........KGs+Ps.........phhGs.Sss.....soPpSShp..........SPhsS.pssst.ssphsSssp.s.......................h.s............sss..................................................................................................	0	15	66	86
+5516	PF05688	DUF824		Salmonella repeat of unknown function (DUF824)	Moxon SJ	anon	Pfam-B_2973 (release 8.0)	Family	This family consists of several repeated sequences of around 45 residues.	23.80	23.80	23.80	23.80	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-8.15	0.72	-4.32	25	1631	2009-01-15 18:05:59	2003-04-07 12:59:11	6	24	187	0	31	888	3	47.80	36	14.57	CHANGED	Dush...s....AuKsKpGEslslsVTs+Du.sG.sPlssssFsLpRscuhsRpss	.................stsh...s.......AuKsKtGEslslsVTs+Du..sG.sPlssssFslpRu.suhsRps......	0	0	0	13
+5517	PF05689	DUF823		Salmonella repeat of unknown function (DUF823)	Moxon SJ	anon	Pfam-B_2973 (release 8.0)	Repeat	This family consists of a series of repeated sequences (of around 180 residues) which are found in Salmonella typhimurium and Salmonella typhi. Sequences from this family are almost always found with Pfam:PF05688.	21.00	21.00	21.20	21.40	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.47	0.71	-4.94	30	1826	2009-01-15 18:05:59	2003-04-07 12:59:11	6	36	210	0	42	1044	6	180.10	34	58.02	CHANGED	GhTsAsGpsolsloQssuhGlKTslsAslssssssoss..hsVIFTVlTSPDospApMWGHMs-TlTs....sGhsF+RPhLsuEhsusss.......ohh-sNEsWuh.hs...sth.ssssst..Cs.hshlPshspLpuLYsspssst..lpTshGWPstts........YhSuspsssss.......apsls.LssGspsshsssss...shhoCl	..............................................GhTsusGssolslsQs.suhGl+Tslssshhs..s..s....ss..oss..hsVIFTVlTSPDos...pAphWGHMs-TlTs....sGhsFcRPh.LtuEhsusss........shh-sNEsWut.hs.....t.tssssst......Cs...hshlPs...hspLp....uLYss....h...s....ss.s....l.poshGWPspts...........Yhuu.spsssss.......atsls.Ls.sGsps.psssss.....thhoCl....................................	0	1	2	22
+5518	PF05690	ThiG		Thiazole biosynthesis protein ThiG	Moxon SJ	anon	Pfam-B_1138 (release 8.0)	Family	This family consists of several bacterial thiazole biosynthesis protein G sequences. ThiG , together with ThiF and ThiH, is proposed to be involved in the synthesis of 4-methyl-5-(b-hydroxyethyl)thiazole (THZ) which is an intermediate in the thiazole production pathway [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.39	0.70	-5.30	28	2805	2012-10-03 05:58:16	2003-04-07 12:59:11	9	11	2724	15	705	5198	2724	239.00	49	90.63	CHANGED	pIus+sFsSRLllGTG+YsS.plhpcAlcASGspllTVAlRRhstss..stssllchlc.pshplLPNTAGCpoAcEAlpsA+LAREsh......sssalKLEVIuDs+pLhPDshpTlcAAEhLlc-GFtVLPYsssDsllA++Lc-sGCuAlMPLuuPIGSGhGlpNhhsLclll-ps.cVPlIVDAGlGsPS-AAtAMElGsDAVLlNTAlApApDPlsMAcAhthAV-AGRlAa.AGhh.p+c.hAsASSP	..................................................................................................................h.IuscpFsSRLhhGTGKaso.plhpcAlcASGupllTlAlRRhsh.....t..p.......................p.............sslLchl......ts.......lslLPNTuGs+oAcEAlhsAcLAREsh.......sosalKLEllsD.s.+..hLhPDs..lETlcA..AEhLl.c-GFh.VLPY...s..s.sDPl.l.s.+R...L..c.-.s..GC.u.....A....V....M....P...L...G...A...P...I.....G.........S.........s...p....G..........l..........t..........s...............t.........h..........L....c...l..........I......l...c.....pu.....s......V..P...V..l..V..D..A..G.IGsPS......c......A....At.AM.E.h.G.sD.AVLl...NT....A...I...A...t...A...pD...P...l....t..MAc...Ah..+.h.A.V.-....A.GRhA..a..AGh...hs..p..p.p....h.A.pASSP.....................................................	0	222	452	596
+5519	PF05691	Raffinose_syn		Raffinose synthase or seed imbibition protein Sip1	Moxon SJ, Eberhardt R	anon	Pfam-B_3204 (release 8.0)	Family	This family consists of several raffinose synthase proteins, also known as seed imbibition (Sip1) proteins. Raffinose (O-alpha- D-galactopyranosyl- (1-->6)- O-alpha- D-glucopyranosyl-(1<-->2)- O-beta- D-fructofuranoside) is a widespread oligosaccharide in plant seeds and other tissues. Raffinose synthase (EC:2.4.1.82) is the key enzyme that channels sucrose into the raffinose oligosaccharide pathway [1]. Raffinose family oligosaccharides (RFOs) are ubiquitous in plant seeds and are thought to play critical roles in the acquisition of tolerance to desiccation and seed longevity. Raffinose synthases are alkaline alpha-galactosidases and are solely responsible for RFO breakdown in germinating maize seeds, whereas acidic galactosidases appear to have other functions [2].\	\	   Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K [3]. This family includes enzymes from GH36C.	20.00	20.00	20.10	20.10	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	747	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.28	0.70	-7.00	11	570	2012-10-03 05:44:19	2003-04-07 12:59:11	7	15	210	0	281	620	6	368.90	23	73.23	CHANGED	hsls-upLhl+s.pslLocVP-NVo....uo.ssss....s..........ssspGuFlGFots.cscS+HlsolGpLcsh+FhSlFRFKlWWoTQWlGpsGpDlphETQalllEhs......p.s.......pt.csYlVlLPllEGsFRouLQsGcsDcVcIClESGSopVcsSoFpsllYlHsussPapLl+-Ah+Al+sHLsTF+hLEEKolPulVDKFGWCTWDAFYLsVsPpGVhcGlKsLu-GGsPP+FVIIDDGWQSIspDsc...c..DutNlVhuGpQMssRLppacENpKF+cYcss..............................................................................s..ppssGhKuFlcDLKpcFpul-pVYVWHALsGYWGGVRP..tssc.h-uplh.PpLSPGltuTMtDLAVDcls.tGlGLVpPcpAp-hY-ulHSYLussGlsGVKVDVhplLEhLuppaGGRV-LuKAYacALosSlsKNFsGNGsIASMpHCNDFhaLuTKQIulGRVGDDFWspDPsGDP.GsaWLQGlHMlHCAYNSLWMGpFIQPDWDMFQSsHPsAEaHAASRAIuGGPlYVSDslG..sHNFDLLKKLVLPDGSILRspaauLPTRDCLFcDPL+DGpolLKIWNhNKasGVlGsFNCQGAGWs.cs++s+sasEsspsloGol+scDlEWpsptss...phshst-asVYh.ppuccLllhs..ussl.lTLcshpFELholsPVpcls.ttslpFAPIGLlNMFNSGGAlp..slcassp...........................sVclcV+GsG+FtAYSSp+Ph+Ctl-Gs-lEFpYps-.GhVslpl	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hht...sMt.....s.............................................................hRsu.....D....ah.......................Hh...shhsshh.h.t.....h.h....sDaDMF..................o........p...........................ut......h.hu..+hhsGsslYloD...s....t..........th............s.......ht.lt.h..h..................................................................................................................................................................................................................................................................................................................................................................................................................................................h............................................................................................................................................................................................................................	0	71	176	235
+5520	PF05692	Myco_haema		Mycoplasma haemagglutinin	Moxon SJ	anon	Pfam-B_3547 (release 8.0)	Family	This family consists of several haemagglutinin sequences from Mycoplasma synoviae and Mycoplasma gallisepticum. The major plasma membrane proteins, pMGAs, of Mycoplasma gallisepticum are cell adhesin (hemagglutinin) molecules. It has been shown that the genetic determinants that code for the haemagglutinins are organised into a large family of genes and that only one of these genes is predominately expressed in any given strain [1,2,3].	20.00	20.00	22.50	22.20	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.79	0.70	-5.77	31	148	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	6	0	49	106	0	382.60	42	66.32	CHANGED	spAlS..pLps.KsNA-phAstFhKpsLsKspLous.............tssspp...QPuNYSFVGYSVDlss.............tppshPNWNFAQRpVWsussp.ss..........................................................stspssssLTDVSWIYSLu...GssuKYTLoFsYYGPo.TuYLYFPYKLVKsuDs.pVuLQYpLNssss.ptIsF............................................s..t..t.ttt...sspssssssphNssPTVs-INVAKVoLosLpFGpNTIEFSVPss......KVAPMIGN......MYLTSs....ssNpsKIYs-IFGN.s.sppsssouVTVDLLKGYSLAosaSTYltpFosL......sssssppssssYLlGaIGGss..sRsssss.........sNh.psPssssss....RTaTIYVNAPpsGsYaISGuYl........osssRsLpFsh....ssssss...NsVolsshspsNWoT....LuTFDT.............ssssssssossssc+TLsLpKGLNKIlluGs.....ssssAPaIGNLTFTLps	..........t..shp..pLpp.KpNAsphss.F.KpsLs+splsus.............tspsptQPuNYSFVuYSVDlss..............tpt.PNWNFAQRpVWsssst.ht..........................................................sttpssssLTDVSWIYSLs...GsssKYTLsFsYYGPs.TuYLYFPYKLVKsuDp..VuLQYpLNssss.ptIpF..................................................................sstssths.sPTVssINlAKVsLosLpFGpNTIEFSVPts........KVAPMIGN......MYloSs....tsNpppIYssIFGN.s.sppssposloVDhLpGYSLAosaSTaltpassh.......sst.ppsp.hYLlGalGGss..sRsshss..........Nh.p.P.ssssp....RTaThYVNAPpsGpYaIpGsYh........osssRsLphps.....sstss...NslTls.h.tpsNasT....LtpFDT.............ttsssssss.ssss++TLsLpcGLNKIll.uGs.....sssssP.lGNLsFTLp.................	0	48	48	49
+5521	PF05693	Glycogen_syn		Glycogen synthase	Moxon SJ	anon	Pfam-B_2874 (release 8.0)	Family	This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3 [1,2]. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P) [3].	19.10	19.10	19.10	19.20	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.23	0.70	-6.28	7	829	2012-10-03 16:42:30	2003-04-07 12:59:11	8	5	520	24	319	797	26	398.40	37	87.51	CHANGED	EVAWEVANKVGGIYTVl+SKA.Vos-EhGDpYshlGPhp-psh+sEVE.lEspsss........l+tslpuMps+GhplhaGRWLIEGsPpVlLFDluSuAatLscWKs-lW-tCpIGlPapDpEoNDAllhGahlAhFLtEFpspsp.........s.tVlAHFHEW.AGVGLhLsRt++lsluTlFTTHATLLGRYLCAGu.sDFYNNL-pFsVDpEAGKRpIYHRYClERAAsHsAHVFTTVScITulEAEHLLKRKPDllTPNGLNVhKFuAlHEFQNLHA.sK-KIp-FVRGHFYGHlDFDLDKTLYFFhAGRYEFsNKGuDhFIESLARLNahLKssss....csTVVAFlIhPApTNsFNVEoLKGQAVhKQLcDTlsplpcplG+RlF-pslp....Gp....lP.-hc-LLppsDhlhlKRslhAhpR..poLPPlsTHNMlDDusDPlLssIRRspLFNpptDRVKVlFHPEFLSSssPLlslDYE-FVRGCHLGVFPSYYEPWGYTPAECTVMGlPSlTTNLSGFGCFMpEplp..-spsYGIYIVDRRa+uh--SlpQLspaha-FsppSRRQRIIQRNRTERLSDLLDW+pLGhaYhcARphALp+saP-.a.h...sphhssst.........h+hsRPtSsPsSP..........osuphuS.psS-sEDs.	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................suhuh.h........hch.....th......lsT..lFTTHAThlGR.ls..uss..hshYs.L..as..........hDt.A.tc........h.........tl.p+ashE+tusH.scsFTTVSpITuhEspcLLc+ts..Dhlh.P.NGhp...s..hhst.h...ppFpsh+t.t+t...+l.phspu...c...h.hG....p.....................s...h...p...-.p.TL.hhhhuGRYEatNKGhDhFlEuLsRLNh......hp..tt........phsVlAFhhhPs.............................................................................................................................PhhTH.h....h.s...pD.lLs.l+phthhNp.tD+VKllFhPpaLs..ussslhsh-Y....-hl...h....Gsc...L...slasS......................................................................................................................................................................................................................................................................................................................................................................................................................................	1	100	174	261
+5522	PF05694	SBP56		56kDa selenium binding protein (SBP56)	Moxon SJ	anon	Pfam-B_2816 (release 8.0)	Family	This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 participates in late stages of intra-Golgi protein transport [1]. The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role and can be implicated in controlling the oxidation/reduction status of target proteins, in vesicular Golgi transport [2].	19.70	19.70	19.70	19.70	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	461	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.55	0.70	-5.99	28	437	2012-10-05 17:30:42	2003-04-07 12:59:11	6	7	298	1	210	468	423	379.30	42	93.69	CHANGED	hpssPs.YsoPttAh.puPtEclsYVssl.ssss..+.PDhLAsVDVDPpSsTYupVlpRl.hPshGDELHHhGWNAC.SS..Ca..scsst...ERRaLllPuLpSSRIYllDT+sDPRpPpltKlIEPpElhp+sGhopPHTsHChssG.IhlSsLG..ss-G..sGsG.GhhLLDp-TF-lhGpWEhsptsthhuYDFWap.tassMloSEWGsPsthccGhsspclhsG.pYG++LHhWDhsp++hhQolDLG.s-sthsLElR.hH-PscshGFVGss.....LSuSlapaa+.-c....sp.W.sscKVIslPuc.s-..u..LPsh......................PsLlTDI.lSLDDRFLYlSsWhpG-lRQYDlSDPtpP+LsGpVhlGGllp+u................shPsspsppLsGGPQMlplShDG+RlYlTNSLYSuWDcQFY.P-hl..GuaMlplDlDsct.GGLsls.sFaV...DFGpt....hhAHplRh.GGDsoSD.ah	........................................sPs.a.oP...Ah..p.....u..PtEplhYh.sl..........st......s...ts.....DhluslDlcPpS.ssYsp....llpph.h.s.hsDELHH.GWNsCSS..C.....scsth....pRphLllPuLhSuRlYllDst.-P....ptPplh........K...........l..l-sp-lht+sshuhPHT..sHChs..sG.lhlSsLG.....s.cG..su.G...GhlllDs-.................F...........plh.G.pW...........Eh......s...........t.......t.s...........................huYDFWap..t+ssMlSo.-Wu..sPs..hhp...p..Gh..s....tc.lts.s..hYG....pplahWDhptpchhQolcLG.t.p.t.hsLElRhhHsPsts.GFVGss.....Lsuslhpaa+....p.s................up..WphccsIplss..sp.sh.LP.h......................PsLlTDI.lSlDDRaLYhssWhpG-lRQYDloDPtpPhLsGplhlGG.l.cs.............................h....psppltG.GPQMlp.lS.hDG+RlYhTsSLausWDc..QFY.Pc.hh.........su.h..hl..........lc.ssst..GGhpls.sFhV...DFsp....t........hhsHphRh.GGDsooD.ah....................................................................................................................................	1	60	99	164
+5523	PF05695	DUF825		Plant protein of unknown function (DUF825)	Moxon SJ	anon	Pfam-B_8370 (release 8.0)	Family	This family consists of several plant proteins greater than 1000 residues in length. The function of this family is unknown.	18.10	18.10	19.40	18.10	17.90	17.90	hmmbuild  -o /dev/null HMM SEED	1390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.50	0.69	-14.39	0.69	-7.17	7	1423	2009-01-15 18:05:59	2003-04-07 12:59:11	7	12	537	0	50	1419	2	520.60	26	64.48	CHANGED	MKcQp....hK.hIhEL+EI.+p.+s.pahhcSWTphNSVGohI+IFF+pERhlKLFDPRIhShLLSRNhpGSpSNpaFTIKGVlLhVluVLIYRhNp+.NMVERKshYLptlhPIPhN.ht.tNDT.EEuhGsoNhNhLIhs..LL.hPKGKpI.Es.hLsspEsThVLsITKht...............................pt.lAtI-..hKEKt.p.Lch........................................................................................................................................................................................................................pLKtS.s..h-hh-slp.EsSEYts.hNp+-...........................................................IpQ.cEcu..WcP.S.lphERpc............................c+.h.pphhPcEhc.cFlGN.T+SlRsaFSDRWS..ELaluS.....sPhE+.Th-pKLLKpp..lsFV..RcSEs....pEIlsLaKIITYL..QpTsSIauISSDPGhshl.Kpp.Dhsp......hpKN.hFshhphFa-ps+...hhcpsFcS..EERlpEhsDLFTLsITEPD.VYcptau...a....s.YtLsppphL..sclhNpRsc.KppSLhlL.slh...-ctc.ahcRIhpK.l..Isstp.....+.Khss.hsp.hhEuls..chIpshI.......puYlRslhNRFahhN+SsRNhc.tIppsQhGs-sLNpRThMKhpIppc..............................sYh.KWSsuocshQEaLEHFlSE...........QKscFpssFD.h.........................phphsp..IsWStshcK..KDh............s+..hh............hh.K.hhFhoKhlhhLuNsLshFh..VShGNhPIpRSEIpI.ELKGsscpLC.......NpLLESIGhpIVHLKKLKP..hLL--ass...SKFlIstuThu.Fh.NclP....hID.hpscpNp.cSFDNpDS.FShI.pDp-NWLNPsK.FppSSLIuSFYKAN+LRFhspsHHFpF.CpKRFPFsVE+s+.pNpsahYGQFLNlLhl+pKhFSLClGccKHsahp+sTISsIES........QVSNIFIPpDF...QSG-pp....YsL.KSFph.o+ssPhV+..RsIYSIh-hSsTPLTEsQIVNhERT.CQPh.D..hNLSDSEtpNhcphLN..FsSNMGLIHo.hS-c.L.SE.....KcKppsh..pl+ct..............................................scKtpMaphhQpDShFShLS.KWNLFpTYhP.FhTSsGYKYLs.lFLDsFS-lL.hhSpt.....VSIh........pDIh.......slSWcILQ.chshhph.lpoE............Ipppahp..NlhLucEhI+RN..sps..h.THLR.sNshEFhYSILhLlhVhGYLlhhalhhVSpAF.ELQp-hcplKSLM.PS.h..IELRKLlD+YP.SE.NSFhLKNlhlhshpplt.Sl.p.Rthuhshph.........l.ulhtpppshNlshID.p.llshlsss.spIs.ptsshplSHsu	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	3	30	41
+5524	PF05696	DUF826		Protein of unknown function (DUF826)	Moxon SJ	anon	Pfam-B_7303 (release 8.0)	Family	This family consists of several enterobacterial and siphoviral sequences of unknown function.	25.00	25.00	26.50	28.10	21.50	18.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.73	0.72	-3.84	3	296	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	140	0	1	137	0	78.60	72	87.10	CHANGED	MSEITSLVTAEAVKEVLRSEEVpSALKQKLRHNLEARLDAEVDAILDELLGs.AuP.sE..AG-oTAsD......s.ss-usEP.QP	.MSEI..TSLVTAEAVK-VLRSEEVRSALKQKLR+NLEARLDAEVDAILDELLGss..AsPtsE......AGDsoApc...........usEP.pP................	0	0	0	1
+5525	PF05697	Trigger_N	Trigger;	Bacterial trigger factor protein (TF)	Moxon SJ	anon	Pfam-B_8447 (release 8.0)	Family	In the E. coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains [1]. This family represents the N-terminal region of the protein.	21.30	21.30	21.50	22.20	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.66	0.71	-4.39	152	4472	2009-09-11 09:24:54	2003-04-07 12:59:11	8	7	4374	14	995	3073	2205	145.40	31	33.23	CHANGED	Mpsphp.p.hsshpt.plplplsspclppplppthpchs+....psplsGFR....GK.VPh..pl.......lcppaGp.p.lhp-slpcllp...cshpculpc....p....plp.sl.upP...pl............p.hp....hppsps..hp...ashph-lhP-l...clss.hcsl...pl..pp.ts.pls-c-l-pplcplp	....................MplohE.p.hpshpt.plolslss-plcstlcpthpc.lsK....p.l..p.lsGFRK..........GK...V..Ph...sl.......lcp+..a....G..t.p..lhp.-slsplls....csatcA.lp-..........p.plp..sl..upP.....pl...............ss.tp......hc.p.Gcs.....ht....assphpVhPEl...c.L..ss...h...c.s...l...cV..cc.ss..-VoD.p-V-ptl-pl...............................	1	347	667	850
+5526	PF05698	Trigger_C		Bacterial trigger factor protein (TF) C-terminus	Moxon SJ	anon	Pfam-B_8447 (release 8.0)	Family	In the E. coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co-chaperones. Trigger Factor is an ATP-independent chaperone and displays chaperone and peptidyl-prolyl-cis-trans-isomerase (PPIase) activities in vitro. It is composed of at least three domains, an N-terminal domain which mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. The positioning of TF at the peptide exit channel, together with its ability to interact with nascent chains as short as 57 residues renders TF a prime candidate for being the first chaperone that binds to the nascent polypeptide chains [1]. This family represents the C-terminal region of the protein.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.40	55	4501	2012-10-02 13:36:56	2003-04-07 12:59:11	9	11	4242	11	991	3166	2160	155.90	23	35.84	CHANGED	oL--L+ppl+cplp.cphppthppphccpllctLlcpscl...-lPpuhlcpEhsph....hpphtpph.t.tGhshpph.p..t...stcphccphccpAc++V+hsLllsclucpcplplo---lppplpchAp.pYs..h.pspplhphhtpptpht....tlcsslhccKsl-hllp	............................................................ol-cL+tcl+cplp.cph.cpt.hc.sp...h+ppsl-tllcs.s.cl....-lPpuh...lcpElcp....h..............hppht........pph...t...G...h......s....cp..........t..........st-p.....h.+c.phcc....p.Ac+RV+hs.Ll.....L.s....tl....s..cs..cp..l..c..ss-.--...lpp.t.......l.p......c.hAp....pYs...........ss..cp.......lh......p...h...h........pptph......tl+pslhpc+sl-hlh.t....................................................	1	347	658	841
+5527	PF05699	Dimer_Tnp_hAT	hATC;	hAT family C-terminal dimerisation region	Albrecht M, Bateman A	anon	Albrecht M	Domain	This dimerisation region is found at the C terminus of the  transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerisation region forms extremely stable dimers in vitro [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.63	0.72	-4.36	49	2390	2009-09-11 20:57:40	2003-04-07 12:59:11	9	113	188	1	1830	2467	15	79.20	19	15.44	CHANGED	-LcpYhp-.shhp.p.........hclLpaWp...tppscaPhLophApclLulPloosuu..EpsFSss..s+hlsct+splp.pslpuLlshcphl	.....................................................................................s.h.t..aWt........tpp.tp.aPt....LtplApp....l..L.s.lPsoosss....ERsFSsh......tph.h.s..c.p.Rsplp.pphpt..lhhhp.......................................	0	435	1044	1597
+5528	PF05700	BCAS2		Breast carcinoma amplified sequence 2 (BCAS2)	Moxon SJ	anon	Pfam-B_7922 (release 8.0)	Family	This family consists of several eukaryotic sequences of unknown function. The mammalian members of this family are annotated as breast carcinoma amplified sequence 2 (BCAS2) proteins [1]. BCAS2 is a putative spliceosome associated protein [2].	21.20	21.20	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.36	0.70	-4.88	18	311	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	249	0	219	303	7	197.40	30	87.94	CHANGED	hss..p............hlDuLPYlDpthp.pssh..+pt....uspLlp-Eh+...phtsstshhpplP...tsshp.h.p.slhpsEh-Rhppt.....pP.httlDh.pRYclPtPsuspts....c.ptWppslpsutsthpHpshRhpNLELLscYGssuWchhN..............cpL-shlpphp+pLtphKcplp-lNtpRKhpQppsut+LppLEppWtpLlucsh-lEhAstpLE....tpltph+ccttp...............p	................................hss...............hhDuLPYhDpth..ssth......+pt.......sttLlppEhp.............thps.s..p.s......hhs......L..Ps.......s.s...............hs.h.p.shhppEh-.Rltsp..................pP...hthlsh..pRYc...hs...sP...ssspts...............shssWpp..slppuhsplpHtshR.hpNL.-.L...hpp.aGs.s...A..Wt...hhN................ppLpph.lpphpcpLpc.....h+..cplpplNhpRKttQ.p.suscLp.tLEppWhphVu+Nh-lEhsh.pLc.......ppl.ph+pp............tt................................	0	72	117	173
+5529	PF05701	WEMBL	DUF827;	Weak chloroplast movement under blue light	Moxon SJ	anon	Pfam-B_6516 (release 8.0)	Family	WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments [1].  Thus several member-sequences are described as "myosin heavy chain-like".	33.00	33.00	33.00	33.00	32.90	32.90	hmmbuild  -o /dev/null HMM SEED	522	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-12.94	0.70	-6.04	36	300	2012-09-25 08:00:20	2003-04-07 12:59:11	6	10	31	0	200	315	0	319.10	18	60.30	CHANGED	uAPFESVK-AVSKFG.Ghl........DWKtt..psh..ERRpt.hcpEL-psQcElschKcph-sAEssKspslpEL-pTK+llEELKhpLE+sppEcpQA+QDoELAclRs.cEhEpGluscsSss.....uKspLEsA+pRassAlsELcuVKpELcpl+c-assllsc+-sAhp+AcEAhsuuKcsE+pV--LThELlAsKEuLEpu+AAHhcAEEc+hssshu+-pDphsWcpELcQu-cELppLppcl..husp-LcuKLcpsoshLhsL+sELsuahp.uclsp.s..............p.....hp.t.lsus+cELEEsKtsl-KApsEsssL+ssusSL+uELEpEKusLssL.+p...+EuhAuhsluuLcsELp+scpElthsps+EpcsccthsE.lsppLQQAupEu-pA+ttAcsAp-Elp+sKEEAEpAKAussshEtRLpAshKElEAAKASEclAlsulcA.LpEpc.sstpsps.t....SssslTLolEEYtpLS++ucEuE-hAsp+VusAluplEtAK-oEs+oL-+Lcpsp+-h-p+KpALctAh	.........................................................................................................................................................h.tth..h..........p.th..ph..sp..httht.tlt........................................................................................................................................................................................................................................................................................................................................................................h.....-Lpthp.t.......lpphtt-...ht...htt...lpt..cl..tp.ptthtphpp....p.....t.tt..h..tlp.ch.....thttpht.h..tp.tt......................t.h...hpphtt-hpth..p.......p.ph..h.tphp..p..htthp.ph....p......t....t..hh.....................................................................................................................................................................	0	30	112	160
+5530	PF05702	Herpes_UL49_5		Herpesvirus UL49.5 envelope/tegument protein	Moxon SJ	anon	Pfam-B_7354 (release 8.0)	Family	UL49.5 protein consists of 98 amino acids with a calculated molecular mass of 10,155 Da. It contains putative signal peptide and transmembrane domains but lacks a consensus sequence for N glycosylation. UL49.5 protein is an O-glycosylated structural component of the viral envelope [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.25	0.72	-4.12	8	35	2012-10-01 21:33:21	2003-04-07 12:59:11	6	1	24	0	0	48	0	93.50	35	98.32	CHANGED	M.sS.shhphshslslssllllulspusss-...................tthsltppt...cFWcuuCSA+GVsIstuouAoVlFYluLlAVllALLuhuYpACFRLFTuShhpccW	...................................................h.hsh.hhlshhlhhuhspus.ss....................t.shh.ptt..hsFWcAuCSA+GVsIstsossoVhFYluLlAVhVAlluhAY+ACFRlhTsshhppp......................	0	0	0	0
+5531	PF05703	Auxin_canalis	DUF828;	Auxin canalisation	Moxon SJ, Eberhardt R	anon	Pfam-B_7298 (release 8.0)	Family	This domain is frequently found at the N-terminus of proteins containing Pfam:PF08458 at the C-terminus. It is a component of the auto-regulatory loop which enables auxin canalisation by recruitment of the PIN1 auxin efflux protein to the cell membrane [1].	22.80	22.80	23.50	23.00	22.00	22.70	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.73	0.70	-4.55	11	176	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	19	0	114	162	0	205.20	37	58.36	CHANGED	PpTPp-s.MEFLSRSWSlS.AoElS+ALts...................................t.t.ppshShsuspsspllh.t...............................stssusPlsPpc.ls..cssphh+ss...............................hTlG+Wh+c+ct..........K++-csRscsAplHAAVSVAuVAAAlAAVsuussss.s....................stpsuKhssAlASAupLlAo+ClEhAEthGAD+-plsoAVpSAVsl+SsGDlhTLTAAAATALRGAAsLKsRt.KEspp....AAlhPsE+ut	....................................................................s.ps.MEFLSRoWS.S.u.p.lspsh..................................................................tt......tt......hh...................................................sh...t..h.....p...h.h................................................................holu+Wh+cpct..............++K-csRhcpAplHAAVSVAulAAAlAAlsAuss.ts.........................s.tp.ss+h.shAlASAAsLlAupC.lEhAEthGAc+-plsusVpSAVss..posuDlhTLTAuAAT........uLRGAAsL+sRh.pc.h..........Ash.Ph-c.s......................	0	12	62	89
+5532	PF05704	Caps_synth		Capsular polysaccharide synthesis protein	Moxon SJ	anon	Pfam-B_7575 (release 8.0)	Family	This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae [1]. 	24.50	24.50	24.50	24.50	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.88	0.70	-5.24	28	400	2012-10-03 05:28:31	2003-04-07 12:59:11	7	9	331	0	91	614	130	240.00	21	70.01	CHANGED	+...........hh.h..tt..h.hppphhhphLccphpphl.pashppppp.pppp........IWhhWhQGh.-sA.PclV+pClpSl++pt..ssaplllLoccNlccYlslPchlhcKhcpGhl...shspaSDlLRlpLLspYGGlWlDATlaho..sslss.hh......cssFFsh....ppstppspshshupW.......................hhluu.ppsp.llshhcchhhpYa.pppsphhD..YFlhchhhpls.......hcp..ph.pphhch.h..hsNtp...ahLtthlpptascphapplppp.o.slaKLoYKhphsptpp....poaap+l	..............................................hhhh.....................................................p....p..tp..+........IWhhWh.Q.G...-sh..P.pllcp.C.hpShc+hh..ssaclll..ls.....c.....c.....N.....l.p..cY..l...s.....h..P..c..h...lh..p+h..p.pst..h.........sh..s....ah....SDllRlsLLtpYGGlWlD..uolhho...psl.sphhh..........ppshash..........pps.t....tt.......p..........h.h...p.....pa............................................hlsu..pps.s.....h.hp.hh.pch.h..h........t...aW..ppp.p.........Y.hh.h.phhh.hh.......hp.......................s.s.......h...h..p.......t.........h....t........phph....................................................................................................................................................................	0	14	42	68
+5533	PF05705	DUF829		Eukaryotic protein of unknown function (DUF829)	Moxon SJ	anon	Pfam-B_7638 (release 8.0)	Family	This family consists of several uncharacterised eukaryotic proteins.	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.43	0.70	-4.67	43	555	2012-10-03 11:45:05	2003-04-07 12:59:11	9	10	206	0	411	571	34	210.60	20	72.88	CHANGED	slll..........................lhGWh.Gups+altKYsshYpc..tGhpslhhpssshphhh.s......ptlpsshcplhphhtspptpt...............sllhHsFSssGhhhhtshh....p...hppppthtphh..lpGhl....hDSuPutsph.htshpuhuts.hsps..............................ht.hhhhhhththhhhhhhhh.pssphhppt...hpshppssht.......ssp......LalYScsDtllshc-lEpahsptcp..pGhp.VpttpacsSsHVsHh+paP..cpYhspltcah	.................................................................................llllhuWh.sup.+pltKYsph.Ypp........uhp.hlh.hpsshhphhh.t.......................................ptht.hhp...t.lhth......h..p.p.tt.....................................llhHsFSsu...Ghhhht.hhh.........................t...hp.ptp........t..p.hh..............l.....t....uhl....................hDSsP..s..ph....shtshshs....h.h.....................................................................h..hhhh.hh.hh..h.h.h....h...hh..h....h.h......s..h...h.h...tp............hp....ht........t.........................h.p......halYS..psD.lhshps...l-p.hhpttcp....................tuh....lp...a..tosHs..sH.hp..t..........p.Yhthh.ph..................................................	0	122	232	349
+5534	PF05706	CDKN3		Cyclin-dependent kinase inhibitor 3 (CDKN3)	Moxon SJ	anon	Pfam-B_5217 (release 8.0)	Family	This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner [1,2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.11	0.71	-4.80	2	187	2012-10-02 20:12:17	2003-04-07 12:59:11	7	6	136	7	85	382	124	132.60	34	62.73	CHANGED	MKPP.SIQsSEFDSSDEEPl--EQTPIpISWLsLSRVNCSQFLGLCALPGCKFKDVRRNlQKDTEELKShGIQDlFVFCTRGELSKYRVPNLLDLYQQhGIlTHHHPIsDGGTPDIuSChEIMEELsTCLKN.RKTLIHCYGGLGRSCL.AACLLLYLSDoISPpQAI	............................................................................................................................................................................Rs.lppD.hppL+.s..G...hps.l.hs.hhspsELsp.....h..p..V....s..s...L.h..c...hhpp.tG..h.....h.h..a..HhPIsDs..s..s.P..-...h....s...p...t..h....p.....l.h...p..E....L...t..t.t...Lp.......s..sp....+..sl.l..HChGGhGRo.s.L...lA.ApLLl.........l..............................	0	29	44	58
+5535	PF05707	Zot		Zonular occludens toxin (Zot)	Moxon SJ	anon	Pfam-B_3320 (release 8.0)	Family	This family consists  of bacterial and viral proteins which are very similar to the Zonular occludens toxin (Zot). Zot is elaborated by bacteriophages present in toxigenic strains of Vibrio cholerae. Zot is a single polypeptide chain of 44.8 kDa, with the ability to reversibly alter intestinal epithelial tight junctions, allowing the passage of macromolecules through mucosal barriers [1,2]	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.55	0.71	-4.84	17	575	2012-10-05 12:31:08	2003-04-07 12:59:11	7	5	398	2	85	1421	205	183.60	20	52.20	CHANGED	hlhllsGtsGuGKThhAVsh.lhs....slp...p....GRhlhT.NlstLs.lc......ph.p.....hp................................h....thht.W.ps....s..psullVlDEspp..hassRsh.st...........................................................shl.shapptRHhGhDllllTQshshlccplR.s.Lsphth+hp+t.shth.tpaphsh..shp.......thtphhp.......hphhphPKptFuhYc.Sss.ps	.......................................................................................l.hhpGhsGuGKo.h...s..l...h....l.......................tht..........p............s..R....l...hs...s....lp...s.lp...hp............th..t.....................................................................................................................t....p.h..h..pa...tt............................ts.u...l...ll.lDE.s..pp..h..ass.cts.....pth...........................................................................................................................................................................................sphh..ph.h....s.pH........R..H......h.......G.......h.......Dl..h..l..h....TQ.sh...s...p....l.....c.p...l.R...p....hs...c...hthch.t..p.t....h.....h.G..h.tth.hphph.......hhpt................ptht.........tthhphspthathYp.Ssp.t.......................................................................................................................................................................................................................	1	21	49	67
+5536	PF05708	DUF830		Orthopoxvirus protein of unknown function (DUF830)	Moxon SJ	anon	Pfam-B_5425 (release 8.0)	Family	This family consists of several Orthopoxvirus proteins of unknown function.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.17	0.71	-4.24	33	2265	2012-10-10 12:56:15	2003-04-07 12:59:11	7	15	1518	6	287	1396	159	163.10	23	72.02	CHANGED	plppGDllFhsss.sslsptlss.......SphsHsuIhhspss.....................s.hhVlEA.hsp.....sschssLpcFlpc......psphtVhRLpsh.....ttthppshphAhphlGpsYshsa..t.....................sc+hYCochVtcsY.pshGl.hsphphhtphhh................................sPpshhcssplptlh	..............................................................................................................hpsGDl.l.Ftp...s....t......u....sh.......sttIphh.op............u...huHluIh.ls..cs........................................................................hl..h.....Eu........hss..................sV..p..hs.s.L...p..p.ahpc...........spchs.lh.R.lssh..........s...pptpc.l.......s..p....p.......u.......p..h....l..s....p..s.....Y..s.hs..h..h.hp..........................................................................................s.sp.h.a....CSchVhcsa..tth.s...h..................h............................................................h............................................................................................................	0	118	176	241
+5537	PF05709	Sipho_tail		Phage tail protein	Moxon SJ, Bateman A	anon	Pfam-B_5084 (release 8.0) & Pfam-B_10063 (release 10.0)	Family	This family consists of several Siphovirus and other phage tail component proteins as well as some bacterial proteins of unknown function.	20.30	20.30	20.30	20.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.63	0.70	-5.24	71	1621	2009-01-15 18:05:59	2003-04-07 12:59:11	6	6	917	9	143	1105	17	296.70	14	91.64	CHANGED	hhhlhshshtsss.....pshpphs.stsG..th.hhs...sphss+plslshhlhst.....shtc...........hpth.+ccltphl..tsccs.hhLhhssc........................................ss+hahshhssp...hsh...cpt..sshs.phslsFhs.spP.at.o...........h..............................................................................................................................................tspthshstsh.hh..................slhNtG...........sspspPh.....lclphp...ssssh.....hslhs.....................................................................................................................................................................................................................................................................................................................................hpsG-....pltls....ptssslhlsuhp.hhsthshs...........pphhtltsGtNp.lplps....ssshplph.pa+..hah	...................................................................................................................................................................................h......h.....s......ph.phs..shsG......th....hhs.......t.p.hp.sh.plslthhhts........sht.s................hp..h.hcclhphh.......stc....p....h....hlh..h.ps.p.......................................ss..hh.ah.s..h..h..s....ss...hsh......ppt......hs.s.......phslphhs....pP.athu................................................................................................................................................................................................................t.tph.th.s.tsh....................................................slh.N.s.G...........shp..s.tsh..........lclpht......tss.sh.....ht.lhp..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hpsuc.....hlhlc.........pppp..pl..h..h...s....s....h......hhsth..s..ht.............................p.h...tlts.G..Np.lphp.........s.hp.hph..pa..ha....................................................................................................................................................................................................................................................................................................................................................................................................	0	59	105	126
+5538	PF05710	Coiled		Coiled coil	Yeats C	anon	Yeats C	Family	This region is found in a group of Dictyostelium discoideum proteins.  It is likely to form a coiled-coil. Some of the proteins are regulated by cyclic AMP and are expressed late in development ([1]).	21.40	21.40	21.40	21.60	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.63	0.72	-3.52	10	120	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	4	0	120	121	0	84.10	32	90.54	CHANGED	MTIlASISSIGNsKSoSKSsluSFuSuo.S..hGSNSIuC....GuCGGuu...hshssssssuGlt......lGsslD..LsusssossGhsuuhhG...................us.....SCGC	.....MTlhuSISSlu...ss...p..o.sS...K.S.s.l..u..S.huuu.o.S.....uSN.SlAC........GuCGGuu...........ss...ssGhh........hsh.sh...lsss..thstuh..hss..t.........................tC.......................................	0	102	120	120
+5539	PF05711	TylF		Macrocin-O-methyltransferase (TylF)	Moxon SJ	anon	Pfam-B_5055 (release 8.0)	Domain	This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the swine industry. It is produced by several Streptomyces species. As with other macrolides, the antibiotic activity of tylosin is due to the inhibition of protein biosynthesis by a mechanism that involves the binding of tylosin to the ribosome, preventing the formation of the mRNA-aminoacyl-tRNA-ribosome complex [1]. The structure of one representative sequence from this family, NovP, shows it to be an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyses the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the mature antibiotic. It is likely that the key structural features of NovP are common to the rest of the family and include: a helical 'lid' region that gates access to the co-substrate binding pocket and an active centre that contains a 3-Asp putative metal binding site. A further conserved Asp probably acts as the general base that initiates the reaction by de-protonating the 4-OH group of the noviose unit [2].	21.10	21.10	21.10	21.10	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.66	0.70	-5.30	16	452	2012-10-10 17:06:42	2003-04-07 12:59:11	6	12	353	11	134	489	715	213.40	27	70.32	CHANGED	ssssppLYLDLl++lloNhlY-D.sh....................ssshlscssacscsRspGpDWPslAHTMlGh+RLcNLQcClEpVLtDGVPGDhlETGVWRGGACIhMRuVLtAaGlpDRsVWVADSFpGhPssssssHshDpthc.LHpaNclLuls..lEpVRpNFpRYGLLDDQVRFLPGWF+DTLPsAPl-cLAVLRLDGDLYESThDALssLYPKLSPGGaVIlDDYsl.PuCRpAVcDYRscaGIs-sIpcIDtsGVYWR+o	........................................................................................t................................................................................................................................h.t..h.t.p..sl..GshlEsGV.a+G...u...u...s...h........h...h...............t...sh...l.........t...s...h...s.........p.......s........R.......p..l..al.hDoFpG.h....Ps....s.sh....p.....p........h............t........c.....h........s..........................h........p......p.....h.....s................h.......t........s.....s...........h-p..V.....p......p...........s.....h..p...p...a.s..........h...h..s.....c......p.lc.....h.l..pGhF.p-.T....L.s....s.....s.....s.....h......c....p.......l.......All+lD....s.........D.h.YcS...Th.su.LptlY..s+..l........s...G.G.........hlll...DD.Y.....s....h...........s...s.....t....p....Al.p-...a...ht..p.ht......................................................................	0	54	98	113
+5540	PF05712	MRG		MRG	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_5530 (release 8.0)	Family	This family consists of three different eukaryotic proteins (mortality factor 4 (MORF4/MRG15), male-specific lethal 3(MSL-3) and ESA1-associated factor 3(EAF3)). It is thought that the MRG family is involved in transcriptional regulation via histone acetylation [1][2].  It contains 2 chromo domains and a leucine zipper motif [3].	20.50	20.50	21.50	22.70	19.10	20.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.31	0.71	-5.41	33	687	2009-01-15 18:05:59	2003-04-07 12:59:11	8	14	280	9	443	658	7	206.40	31	57.75	CHANGED	ssst.cusc+ppst............p.th....hpcspl...plplPspLKphLVDDWEhlTKpp..+lltLPs.phsVspILccahpp......h...p.ppspsss..........p.p.............................hlcElls..Gl+hYFspsLu..phLLY+hER.QYtplhppp........................................................................................................................................................................sshs.SplYGA.HLLRLhlp...LPphlutos.hDppolshLhpplpphlpalspp...pchFsppsY	......................................................................................................................................t.p.sppp............t..........ppcth...........hpc.pl...plplP-pLK.hLV..D.DW-hls+pp............pLh..tL.Ps....p.hsVssIL-cYhph...............hp...ppsssss................t.....................................................hlp.Ells..G...l+...pYFshhLs..s.LLY+..aERsQYt.clhtpp................................................................................................................................................................................................................................................................................................................................................................shs.SplYGA.HL....LRLF............V+...lsthL....uho......s....hspc.sl..t.......hLhp.hlp.pFL....paLscpt..sphFstp..................................................................	2	114	174	307
+5541	PF05713	MobC		Bacterial mobilisation protein (MobC)	Moxon SJ	anon	Pfam-B_2832 (release 8.0)	Family	This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region [1]. The absence of MobC has several different effects on oriT DNA. Site- and strand-specific nicking by MobA protein is severely reduced, accounting for the lower frequency of mobilisation. The localised DNA strand separation required for this nicking is less affected, but becomes more sensitive to the level of active DNA gyrase in the cell. In addition, strand separation is not efficiently extended through the region containing the nick site. These effects suggest a model in which MobC acts as a molecular wedge for the relaxosome-induced melting of oriT DNA. The effect of MobC on strand separation may be partially complemented by the helical distortion induced by supercoiling. However, MobC extends the melted region through the nick site, thus providing the single-stranded substrate required for cleavage by MobA [2]. 	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.45	0.72	-3.99	27	1793	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	994	0	198	1402	105	47.80	25	39.04	CHANGED	ll.......ppLutlGsNlNQIA+phNs.....thss.cph.h.httLh.plpppLpplpc	........................hpLsplGsNlNQIA+phNp.........tth..ttt..ph..................l..tl.t.......h........................................	0	71	131	175
+5542	PF05714	Borrelia_lipo_1	Borrelia_lipo; 	Borrelia burgdorferi virulent strain associated lipoprotein	Moxon SJ	anon	Pfam-B_7866 (release 8.0)	Family	This family consists of several virulent strain associated lipoproteins from the Lyme disease spirochete Borrelia burgdorferi.	20.80	20.80	20.80	20.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.37	0.70	-5.23	18	520	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	34	4	27	422	1	182.80	25	78.06	CHANGED	ppppscchKNsLLsD..........L+NLIEpAsp-+-KYhK+hcEEPs-Q....YGIhu..FcpL.Wstu.spEslu-s.oc+ShpYR+hsYus.LNslcss.cLKchocIlh.........hutpsptlaNlhpplGtslDpllspLYsKKDsLsKL-Is.cLc+LKNshEKlLSlKphlScMlsQLLLDYpssps.I+TDssKLcsals.pl.pQh.cKpcEu-pLKspIhoI.tsl	..................................................pp.pp...p.h.hsp...........pp....h.c.s...t.....pchcp.h.h.K.....p.h.....c.tp..ppp......................h.thtt.......hchlth.........h................h-.h..tts.....pphph++hhYos.L.s.appp.clpphtpIlp..............t..thh....t.thlh....p.h....h.....hsl..php.....l-phlt.hl...p..p..p.Ds..L.p.php.p.plcpLhpph-p.LplKpphtctlp..phl.-......Ypp..N..p...stI+s...-.pt...Ltp.ahp...............p....tp..th..........h..................................	0	17	17	17
+5543	PF05715	zf-piccolo	Zf_piccolo; 	Piccolo Zn-finger	Yeats C	anon	Yeats C	Domain	This (predicted) Zinc finger is found in the  bassoon and piccolo proteins (e.g. Swiss:Q9JKS6). There are eight conserved cysteines, suggesting  that it coordinates two zinc ligands.	30.00	30.00	30.10	33.90	29.00	29.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.50	0.72	-3.96	12	212	2012-10-03 17:27:21	2003-04-07 12:59:11	8	9	36	0	101	168	0	59.80	62	3.12	CHANGED	s+shCPLCpTp...luo.s.sNFNTCTpC+spVCNLCGFNPsPHLTElpEWLCLNCQhQRAL	......s.pshCPLCpTp....lu.o.p.-.s....PNaNTCTpC+spVCNLCGFNP.sPHLo.E.h.pEWLCLNCQhQRAL........	0	4	17	41
+5544	PF05716	AKAP_110		A-kinase anchor protein 110 kDa (AKAP 110)	Moxon SJ	anon	Pfam-B_5702 (release 8.0)	Family	This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction [1].	25.00	25.00	26.70	25.90	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	685	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.55	0.70	-13.31	0.70	-6.54	5	156	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	35	0	76	141	0	335.10	35	35.52	CHANGED	oP+KSLSKIASELVNETVoACS+NhssDKAPGSGDRs.uo.QS.PsL+apSTLKIKESsKcGpGPDsRPGSKKSFFYKEVFESRNuGDA+EGGR.hPt-RKhFRs.-RPDDFosSIScGIMTYANSVVSDMMVSIMKTLKIQVKDTTI.ATIVLKKVLLKHAKEVVSDLIDSFMKNLHNVTGoLMTDTDFVSAVKRolFSHGSQKATDIMDAML+KLYSVlhAKK.PEplRKscDKSESYSLlSMKuGsGDPKsRN..LNFAoMKSEsKlREKspocs.ssKEcTCAETLGEHIIKEGLTlWHpoQQNpsKSsuhptu.....ppQhtss.-hshthP.D.sphs..tsPpsPEKsENFMs-SDSWAKDLIVSALLLIQYHLAQ.............................GGspDA+SFlEAAuoTNhsPssSPss+DEu+L+Ss.l.hs-.EpsEKKDLpSVlFNLIRNLLSETIFKs-csCEuKs+cp.lKE-+uspCERPl.......Sssss+hsED-E.TsGAlSGLTKMsssplDGpMNGQMVDHLM-SVMKLCLIIAKSCD..AuLAELGD-KSGDASR.oSAFP-NLYECLssKGTGoA.EAlLQNAYQAIHNEhRuhSuQPPEGCthPcVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAsAVEKGpSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMuNL	........................................................................t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..llV.N.s.psph..tpLpAsLQWlAASphslPhlYFhtsp-s.hEK..........h.plsthstcKuapVG-lhptVhpatK...c..p.pt..tp.sphp.LhDWLh..........................	0	4	8	28
+5545	PF05717	TnpB_IS66	Transposase_34;	IS66 Orf2 like protein	Moxon SJ	anon	Pfam-B_5707 (release 8.0)	Family	This protein is found in insertion sequences related to IS66.  The function of these proteins is uncertain, but they are probably essential for transposition [2].	22.10	22.10	22.30	22.30	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.29	0.72	-4.62	135	3276	2009-01-15 18:05:59	2003-04-07 12:59:11	8	9	1155	0	503	2167	362	95.80	41	89.63	CHANGED	sss+laLsstssDhR+GhsGLuslVppslth-PauGslFlFps+..RtD+lKlLaWDusGhsLhhKRL..EcG.+Fh.W.P..sspt..slpLos..tQLphLLcGlDhppsp.t..sh	.......................s..pla.lssuhsDMRpGhsGLuthVppsh.p...-P.a.S.G.p.lF.lFp.G+..+tcplK.lLahDus.G.hs.LhhKR.L..E..p.G..+Fh......W..P...sscps...hhtLo...tQlsh........LlcGlshpt.t.....hh..............................	0	117	266	386
+5546	PF05718	Pox_int_trans		Poxvirus intermediate transcription factor	Moxon SJ	anon	Pfam-B_5843 (release 8.0)	Family	This family consists of several highly related Poxvirus sequences which are thought to be intermediate transcription factors.	21.40	21.40	22.30	25.20	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.39	0.70	-5.94	12	61	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	0	44	0	375.30	68	99.35	CHANGED	MccLFpaL+sIEDcYsRTIFNFHlh+ss-lusIYshh+-+IuspshFsclV.sscl+psIKKLlYCDIplTKHIINpssYsshssssppss..KhuQaFDIphssss..hStRTs-IF-pDKSSLlSYIKTTNKKpKlDYGEIKKTlHutspo..sYFSG++SD-YLSTTV+sspspPWIKoISKRhRlDIhspuIlT+GKSSILQTIEIlasNRTCVKIFKDSThHlILSKDKsEpuClsllsKLFpsYclLFtLlaslTtsptFtphtssuscllssssF-EKlshI+pht..c.YGlpNFKlGMFNLTastsIsaTVFPSLLct.sSKIKFFKGKKLNIVALpSLc-CtpYVp.ApslLctMpcRSphLsslsItosSV-pLKpLLh	....................MDsLFoFLH.EIED+YuRTIFNFHLISsDEI.GDIYGlMKERISuEshFDNIVhscDI+sAIK.KLVYCDIpLTK.HIINpssYPlaNcoups....KpspaFDINoDsus..ISpR.TVEIFEREKSSLVSYIKTTNKKRKVsYGEIK.KTVH..GGTsu..NYFSGKKSDEYLSTTVRSshsQPWIKTISKRMRVDIINHSIVTRGKSSILQTIEIIFTNRTCVKIFKDSTMHIILSKDKcE+GClchIDKLFhVYhsLFlLhcDIhpN-hFcEVAslss+VLouTshDEKLhlIK+hA..DsYGVsNFKIGMFNLTFIKul-HTVFPSLLD-.-SKIKFFKGKKLNIVALRSLEDClpYVocSEshl-hM+ERSsILNuIDIETtSVD+LK-LL.l...............	1	0	0	0
+5547	PF05719	GPP34		Golgi phosphoprotein 3 (GPP34)	Moxon SJ	anon	Pfam-B_7957 (release 8.0)	Family	This family consists of several eukaryotic GPP34 like proteins. GPP34 localises to the Golgi complex and is conserved from yeast to humans. The cytosolic-ally exposed location of GPP34 predict a role for a novel coat protein in Golgi trafficking [1].	23.00	23.00	23.80	23.30	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.53	0.71	-4.25	88	612	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	392	9	331	621	2	216.50	28	82.18	CHANGED	Ls--lhLLuhcsp.pGp....hhssshphu..LsuuhLhELsltGclpls..........ps+......l.tsh..sspsss......................-s..lLcps....lptlt......ptc.spp.....spsWlpt.ps............+sh.pctl...tpp...Lssc.Gllcpccp..phLshh...hh...pas.hsD...sstcpplpp+lpssl....sttss............................................sscsss.......LlsLhtus.slhpphh.ss...............................ppscptlpp...........lsptshhst.........................................................slcpt......lpphpsAs	......................................LhEEl.LLL.uLc-c...pGhh...hhsssluhu..LpGshL....l....ELuhcGRlplp...................pc+........................l..hlh.ssssTG......................-s..lLD-uLchl+............spt..s.o.........lpsWI.chhsG..............+sl.R-+l.scs....LV-+.GlLps.E+p....sh.L.h.h..shssaP..ls-...ss.h+pclhc+lpssl.....p.ssts.................................................shRshu.......LlsL.AaAu..sllcssh..ssh..p...c........................ppscphltp..........h.p.hs.............................................................................tht.................................................................................	0	118	192	272
+5548	PF05720	Dicty_CAD		Cell-cell adhesion domain	Yeats C	anon	Yeats C	Family	This family is based on a group of Dictyostelium discoideum proteins that are essential in early development ([1]). Swiss:P16642 and  Swiss:P16643 are located on the cell surface and mediate cell-cell adhesion.	19.00	19.00	20.50	19.10	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.52	0.72	-4.34	6	17	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	4	0	16	20	1	76.10	30	37.11	CHANGED	IhN--GESTISGKuaPLPsPhIaPsPYhhRFhcYchEGpLWsNcEFclKSGKIEasGEEaDIPpSpsshhKh.D-ptshI.l	...........l.sptGcSoIpGhshshPs.h.aPsPahhph.h.p..YphEG.s.l.asppcFclpSuKlEhsGc.ca-lPsSpssh.c..-p......................	0	15	16	16
+5549	PF05721	PhyH		Phytanoyl-CoA dioxygenase (PhyH)	Moxon SJ	anon	Pfam-B_5670 (release 8.0)	Family	This family is made up of several eukaryotic phytanoyl-CoA dioxygenase (PhyH) proteins, ectoine hydroxylases and a number of bacterial deoxygenases. PhyH is a peroxisomal enzyme catalysing the first step of phytanic acid alpha-oxidation. PhyH deficiency causes Refsum's disease (RD) which is an inherited neurological syndrome biochemically characterised by the accumulation of phytanic acid in plasma and tissues [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.38	0.70	-4.30	39	3239	2012-10-10 13:59:34	2003-04-07 12:59:11	8	56	1181	23	1723	3267	6124	205.00	16	65.62	CHANGED	accsGalllcs....hlss.pplsthppphppl.............................tthtsstphphhhptpttsststhh.....ts.pthtthhcs.............hhsshscphlspssh.................htshh....hh+tsphGsss...shHpDhthh........ttP....tphls....hhlAl-Dhsh-NGshhhlPGSHph..t....hh...th.tt.............................tpthlsh.hctG-sllacsplhHuotsNpost...Rpu	.................................................................................................................................................................................................pppGalllps....hhs...pph.t.t.h.p....p...t.h.t.p.h..............................................................................h.....t.t........t...h.....t...h...h..h.t....t...t....h.....h.t.....t.....t.hh....................t...hh.th.hhps.................................thhshh.pplhstphh....................................................h.pshh..........hh.p...s.t....Gsts............sh.H..........p...........D...h.t.h..h...............................hps..............phls...........hhl.sl.s..-.s...s.......c..s...G..........s...........hh..h..........l.....P...G.....S......H..p....h........h.................h..t.tth.tt........................................................................t..t..t....h.h....h..t..h....ps.Gsslhapsp.hh.H..s..u.s..tN..tott...R.....................................................................	0	633	1084	1476
+5550	PF05722	Ustilago_mating		Ustilago B locus mating-type protein	Moxon SJ	anon	Pfam-B_5804 (release 8.0)	Family	This family consists of several Ustilago mating-type proteins. The b locus of the phytopathogenic fungus Ustilago maydis encodes a multiallelic recognition function that controls the ability of the fungus to form a dikaryon and complete the sexual stage of the life cycle. The b locus has at least 25 alleles and any combination of two different alleles, brought together by mating between haploid cells, allows the fungus to cause disease and undergo sexual development within the plant [1]. 	25.00	25.00	37.50	35.50	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.85	0.70	-5.10	2	41	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	6	0	1	40	0	123.50	69	42.78	CHANGED	Il+KFARpDRsRMKhLVpAKh.uSs.Ss.s.uTpsSLssNLDDlLp-NLG+.LTPsDKppFEDDWsSMISWIKYGVKEKVGDWVYDLsAAsKKo.P+sG.sRsVTTsApRpPARKTtstspsKs+pAp.RASpTPShDST...StLESTPELShCSTADsSFSoFsSshShupasPFQp..pl.QSPolpsRGsRKVKALPKRAupp.PsE...lsN....................................................GpIPFl.........sLSsAFs	....ILKKFAREDRSRMK+LVRAKLSSSNQSoPPS.................................................................................................................................................................................................................................................................................s..........	0	1	1	1
+5552	PF05724	TPMT		Thiopurine S-methyltransferase (TPMT)	Moxon SJ	anon	Pfam-B_5821 (release 8.0)	Family	This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines [1]. 	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.50	0.70	-4.90	12	1046	2012-10-10 17:06:42	2003-04-07 12:59:11	6	7	838	11	423	2913	640	189.50	24	87.81	CHANGED	hstshWpppWtssphsacQppsssLLh+ahss..ps.sshRsLVPhCGpuhDhhWhAspt+.VlGl-lS-hAlpchhp-ts.....pPp..hpphssh+c.............DhFshpsppl..hDhlaDRushsAlsPchRspYupphhpLL.ssuc..hhLlTLpYs.scts.GPPF.Vst.....tEhctlhs.sshcltplcp.tDsLss..chtt.slpthtEplahl.p+p	.........................................................................................thWp.pp...a...t...p...s...p.....h...s...a...c......t....p..........s.......s.....s....h......L...h....p....a.......h...............p...........p.....................t...........................t..........t................t.....t......c....lLl.P........h.CGc.u..h..D..h..h..a.L....A..s...p...G...........a..p.V.hGl-l..S..p..h..A..l...p...p...h...h...p.cp.th..................p.p.....ht..p..h......s......s..h...pt...................t....t..l...p..h..h..t.u..Da....F......s.......h...s..........s....t......t......h......t.....t.....h..chl.a.D..p.s...h....h....s..A..L......s.........p.....h.....R....t.....p.......Y..s......ppht....pl..ltssup.............h.L..l.....s........h.....t...a.......s........t.....s....p.......h...t.....G...P..P...a.s.l.s..t............t-l.pth...hs....h...h...p.l....h.................................t..................................................................................................................................	0	151	249	342
+5553	PF05725	FNIP		FNIP Repeat	Yeats C	anon	Yeats C	Repeat	This repeat is approximately 22 residues long and is only found in Dictyostelium discoideum. It appears to be related to Pfam:PF00560 (personal obs:C Yeats). The alignment consists of two tandem repeats. It is termed the FNIP repeat after the pattern of conserved residues.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.03	0.72	-4.00	34	6356	2012-10-02 21:32:02	2003-04-07 12:59:11	7	134	22	0	5165	6328	244	42.60	32	40.91	CHANGED	FN.Qs.lphsslP.............................pulppLph.ussFsp.lp..hssLPpSlppLphupp	..............................................................aN..p....l..t.......s...s...l....P...................................................................s..o..l......p...pL.pF.....G....p.......p....F....N...Q....s..lp.............s...s....l...P..s...S..lp.p.Lphu...................	0	2305	5161	5165
+5554	PF05726	Pirin_C		Pirin C-terminal cupin domain	Yeats C	anon	Yeats C	Domain	This region is found the C-terminal half of the Pirin protein.	21.30	21.30	21.30	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.24	0.72	-3.95	34	2522	2012-10-10 13:59:34	2003-04-07 12:59:11	8	12	1617	3	1004	2315	1370	103.60	28	34.49	CHANGED	alDlpLpsGuchphs.hspsapshlYll...pGs.s...........plsupp.........lstpplslhu...sGsplhlpus...pss+....hlLluGcPlsEPlhhaGPFVMsop-EIcpAhp-acpG..+Fs	................................................................hDlplp.s.Gu.p..hsls....h.s...p....s....a.....p.shlYll...cGs..l.........................................pl..supp.......................lp.ss..p.hslhs.............sGs.p...l...p...l.p....As.............psuc..............llLl..u.G..c..Pl.sEPls.ha..GPFV.Msoc-EIppAhpDapsG.ch...........................	0	307	618	837
+5555	PF05727	UPF0228		Uncharacterised protein family (UPF0228)	Bateman A	anon	SWISS-PROT	Family	This small family of proteins is currently restricted Methanosarcina species.  Members of this family are about 200 residues in length, except for Swiss:Q8TMK1 that has two copies of this region.  Although the function of this region is unknown the pattern of conservation suggests that this may be an enzyme, including multiple conserved aspartate and glutamate residues (Bateman A. pers. obs.). The most conserved motif in these proteins is NEL/MEXNE/D, where X can be any amino acid, which is found at the C-terminus of these proteins.	25.00	25.00	30.80	29.90	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.83	0.71	-4.39	13	26	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	5	0	26	25	0	120.50	39	64.74	CHANGED	MThNYoI-Ysoshhst+YYIhlDKDch.DltcE.LpK-......csWT.s....sI+KGDYYlIsVSEQAIcDcsFLslLcK.NlQVKKhVaChIpF..sDGS.......+s.WIPEcDAlRIKNELEpNEsVhoVthDYlhs	.................hshNYsI-YNsshhsscYYIhVDcDch.slhpE...LpKs......csWh.s........lKKGcY.YlI.lSEpslpDcsF............LslLcKpsLQlKKhVhChIpF..ucGo.......cs.hIsEcDAl+IKNELEpNEpllhVth-.l..s........	0	9	13	13
+5556	PF05728	UPF0227		Uncharacterised protein family (UPF0227)	Bateman A	anon	SWISS-PROT	Family	Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes that are distantly related to the Pfam:PF00561.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.98	0.71	-4.57	9	1870	2012-10-03 11:45:05	2003-04-07 12:59:11	7	4	1161	0	305	1448	549	179.10	38	93.88	CHANGED	hllYLHGFsS.SPtsHct.l.hpahspcshhlshss.p.tcp.pphlpclcphltphsscp...shlsGsuLGGYaAphlu.hpGl+p..VlhNPsltPhcshsshlsc............Epa+.hphKslpsht.............hcp.s+hhllhu+tDElLD...pcssuchpshhphVh-ss.sHtFpshucalpplhuFts	............................................................................llYL.HGF...sS..SP..........t......s.........t....c..........t.....s..l....h....h......p...a........lst...c.h................l........p...h.............s............p........................................p....c...h.........h....c..............l.........-.....p....h......l....t.....p...p......s.s..cp................hllGsSLGG...YaA.......p.h....l....u..........h.....h.......s.....l...tt..........V..l....l.............N...P..u...l..p...P...a......E......h...p....s...h........l..s...p....................................................................................E.......p..h..p......h..s.....h....K..s.....h.ph.......................................................cs.....D.phhllhppsD......E......l......LD.......pps...s...t.....h.....h.....t.....s.....h.....h.....p.........h.....V...h....-ss..sH.tF...p..s.hp.s...ahp.p.IhsFh.s..............................................................................................................................................................	0	55	142	229
+5557	PF05729	NACHT		NACHT domain	Bateman A	anon	[1]	Domain	This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation [1]. This family is closely related to Pfam:PF00931.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.90	0.71	-4.59	26	5874	2012-10-05 12:31:09	2003-04-07 12:59:11	7	749	661	0	4173	9193	904	159.70	19	16.53	CHANGED	cslllpGpAG.GKTsLhpplshtWApuph.p......hphlFahss+phspts.......uLs-lltsphspsssshsc..............h...lhphspRlL..............hllDGhDElts..s...........p.t...hLLtsLlpcplLspsplllTsRssuhtp...ltptlpps...............hhpltuFspsptpphh.pcaassp	.....................................................................................hlhlpG.sGhGKo.s....l....s.........p.........p.........h..........h.........h.........p..........h........s........p........s......p........................pt................h..th.....h.....a...h...h..s...h..p....p...h..s..t......p.t.......................sl.t.p....h..l......h.....p........t......h....s....p....h....t....t......h.tp............................................................................h...h.....p.....p...............t.....p.....l..l....................................................................h..l.l..D.G...l..DE...hp...t..p......................................................................h...h..l...t..........p...l.......l........p......t..................h....s.....p....s........p......l....h.......l...o.......o...R..s..t...t..h..............h..t.....h....................................h.l.........h............t...............t...................................................................................................................................................................	0	1337	2441	3535
+5558	PF05730	CFEM		CFEM domain	Bateman A	anon	[1]	Domain	This fungal specific cysteine rich domain is found in some proteins with proposed roles in fungal pathogenesis [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.52	0.72	-4.15	114	969	2009-01-15 18:05:59	2003-04-07 12:59:11	6	17	154	0	757	948	0	66.30	25	23.45	CHANGED	thsslPsCAhsChsp.sh......ss..Cs...hsDhs....ChC...stsshtsslssC.....lt..ssC.s.ss.......ps..............ssh....................shss.shCu	..................t..stlPsC.u......h..s.Chtp.sh....s......ss...Cs........hsDhs........Cl..C........sps....s....ht...s......s...ltsC.......lt.....ss..Cs..sp.......-t...........................ssh....................shsp.shCs............................	0	152	421	636
+5559	PF05731	TROVE		TROVE domain	Bateman A	anon	Bateman A	Domain	This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs.  This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding. 	21.30	21.30	28.20	28.00	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.09	0.70	-5.70	9	567	2009-01-15 18:05:59	2003-04-07 12:59:11	6	42	303	6	249	524	40	237.30	18	39.07	CHANGED	lpsspGshsapssspscltp........h....LshuspssoaYtstpc.spsphpcll+tltpt-sphllphhhhhppctphtchsshlhAlAlhtp.s.....+...................tshchhscVs+hPocLhphlpa..................ph..tsspptsshs+slR+ulschasphs....thtLsKY...c.pRsuhph+DlhRhsH.cssss................thsthhpahhct........................h.h...h.pphhptpssptlphLpua.......p.....t.hpchhh........................................shE+.los+ls............stpVWcsLlps..hPhhAhLRNLsslscsGV.spsps....hVhpRLsctctlc+SRhaPachLsAhcshspucup.+sp..............................................................hpW.ss.plhp....ALEpAhthu.hcNlsPhss	.......................................................h...................................................................h..hht..h.......p.s..h..hp....h.hpt.t..h...h.p...hhhs...hh............................t...................................................................hh..hh.thhp.sp.hhthhth................................................................................................................hst..pthh.phh.p.h.....t.thhph.......p..tt.t.p.tc.....p..t.......................................................hh......h.........................................................................................................................................................................................................................................................Wttlh.p...hsh.th.hhpLtph.t.s..h..t....................lhthltp...t........lhpuh.hPhphh.A.p.h..t........................................................................................................................................................lt.uh.hs....h..............................................................................................................................................................................................	0	97	149	203
+5560	PF05732	RepL		Firmicute plasmid replication protein (RepL)	Moxon SJ	anon	Pfam-B_5929 (release 8.0)	Family	This family consists of Firmicute RepL proteins which are involved in plasmid replication.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.05	0.71	-5.03	4	349	2012-10-04 14:01:12	2003-04-07 12:59:11	6	2	297	0	26	301	50	118.70	27	83.06	CHANGED	hppRhtshhpGoEpaINpsoGElhEhphlhhcppshNFsKsalppllphLDLlGNpKs+ls.allcNLN.psNslItTsRclAccTGhSLpTVppThKhLp-uNhlK+ps.GVhhlNP-lLh+Gscpc+h.lLlpFpph-pEspchp.........................................EsuLhpht.hK	.....................................................................................................................................................................h.-..l......l..G.....p..K.....c......h..cllp.a..lh..-.s...h-...ps....s.........h....l.....h.....h...s...h.s......-..l......p...cc..l.....s......h..S.+.sT.lhpshKhLc-pp.ll...p.....+.h......p...........p...........G......h.........Yh...lN........................................................................................................ht..................................................	1	7	19	23
+5561	PF05733	Tenui_N	Tenuivirus_N;	Tenuivirus/Phlebovirus nucleocapsid protein	Moxon SJ, Bateman A	anon	Pfam-B_5998 (release 8.0) & Pfam-B_19756 (release 10.0)	Family	This family consists of several Tenuivirus and Phlebovirus nucleocapsid proteins [1,2]. These are ssRNA viruses.	25.00	25.00	25.10	26.50	18.10	24.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.34	0.70	-5.07	12	395	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	94	10	3	299	0	203.80	40	85.00	CHANGED	-hpchh.chuspAlc.....csplhsalsphsYpGaDAt+ll.pl..Lpc+u...Gcsat+DlphhIVhphTRG.....sh.cKh...hsstGucpsppLls+Yslhp..Gssu.DsITLuRlAuhFsshohpslpslo..s+LsVsuoshssh.uhsh.hh.hhPpFhsL.ssohP....cshtphlhshHhLahh.ho+ph.ssh+tcp+s.....-llchhsp.hshshsup.lsspc....R+clltsFtl	..................phpchhs-hupptls.....hs-l.sastphtYtGaDstplI.tl...LK-pG.........G-shsK.DhphhIlhthsRG.....shhpKh...hsstGuppstsLls+YGlhpp..Gss.uhssITLuRlApshs.shoppssttlp..thhsVsusshshh.ups.shh.hhPpFhtL.s.ohs....cuhs+hLhssH.la.hphoKph.s.ch+ttp+s.....-hhp.hpt.hhhsspSt.h.pcp....++.h...h......................	0	3	3	3
+5562	PF05734	DUF832		Herpesvirus protein of unknown function (DUF832)	Moxon SJ	anon	Pfam-B_7683 (release 8.0)	Family	This family consists of several herpesvirus proteins of unknown function.	18.80	18.80	21.90	72.40	16.90	16.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.36	0.70	-5.15	13	32	2009-09-11 10:40:49	2003-04-07 12:59:11	6	1	24	0	0	29	0	222.20	27	50.08	CHANGED	MphslPVhGlspppp....pcWppllssFtscsssspsls.L++hFc.......tcschuhLuSLllLhphltsspptpp+ts.Llpsh.ts+hlApplacclhspps.pps.h-phFt-C+sRLtLLLEpsCGChpChpsscuLpcsp.thhR.P+LpPHpppstutshLsplaNpslLssssslscapltsLh.sscphsshs.chpsEsshlusClhhCWLaalLppalps-lpslcpsl	..hp.slslhhlspcpp....ppapplhssFts..psssspslt.l+phap........pschuhLuuLlhLhphl.sstphtp+.s.Ll.shptshalspplah+lhspps.tps.hcphatcstsRLthllEpuCGC.pChpssctLpphp.thhcPP+lpPHpcpC.utshLstlhppslLssshslStasls-Lh.ssppa.thsssh...phEhshlsoCL.hCWlahllhcalpp-hthLcpsl.	0	0	0	0
+5563	PF05735	TSP_C	TSPC;	Thrombospondin C-terminal region	Bateman A	anon	Pfam-B_1875 (release 8.0)	Family	This region is found at the C-terminus of thrombospondin  and related proteins.	25.00	25.00	25.40	26.50	18.50	23.90	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.24	0.71	-4.75	10	444	2009-01-15 18:05:59	2003-04-07 12:59:11	7	85	95	6	222	377	2	188.30	65	21.57	CHANGED	QsDPsWVVhspGsEIhQslNSDPGLAVGccsasuVDF-GTFFIsssoDDDYlGFlFuYQssu+FYlVMWKKusQoYWpspPFcAsApsGlpLKlVcSsTGPGptLRNALW+TGsTssQV+LLW+DPhslGWKc+TAYRWpLpHRPsI.GhIRlphY-Gs+LlhDSGNIaDsTl+GGRLGVFCFSQEpIIWSNLpY+CNDsl.P	.................QIDPNWVVh.sQGhElVQTh.N...S.D.PGLA.VGa................stFsuV.DFpGTFaV.....N..T.s..p...DDDYAGFlFGYQ......s......S......SpFYVVMWKQ....s.pQTYWpssPhRAhu.sG.lp.....LKs.VpSs..TGPG..EaLR.NALW.HTGsTss.....QVRhLW..+.D.P.+Nl..GWKDhTuYRWpLpH.RPps.GaI..R....VhhY.EGpplhAD..SGslhDp..T..htGG.RLGlFsFSQE.lhaSsL+YcCp-..............................................................................................	0	43	61	129
+5564	PF05736	OprF	OprF_membrane; 	OprF membrane domain	Bateman A	anon	Pfam-B_4079 (release 8.0)	Domain	This domain represents the presumed membrane spanning region of the OprF proteins. This region is involved in channel formation and is thought to form an 8-stranded beta-barrel [3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.14	0.71	-4.76	4	245	2012-10-03 17:14:37	2003-04-07 12:59:11	6	2	226	0	16	668	18	163.40	62	55.34	CHANGED	MKLKNTLGhAIGSLlAATSFGALAQGQGAVEhEsFhKKpasDSV+phcs.G...GuSlGYFLTDDVpLsLoYDcsppsRusDsTGspKltGspouLcA.YHFGssG.DuLRPYVpuGhuHQSlsNl.ssGpsGRsQSThAssGAGsKaYFT-NhYARAGVEApYsLDpGch....-auAhVGlGVNFGGuu	......................................................................................TLGlsI.G.o.llAA....T..ShG..A..LA......Q...G.....Q.....G..A...V..E.hE....h....F...h....K..K.....a...D.....S...s.....+.....s........h.....c........s........G..........Gu...u.lGY.....FLTD....D....V..pL..t..L......u.....Y.s..c....s....H....s...s.......R...u.........D....s........s..t....s....p.....p.....I....K..G..s.s...T.....uL....DA..h..YH......F.ss......P.G...DsLRP.Y..VS.A..G.....F..u......a.....Q..S..l.......s....................ps....u.....+........s..G.....R...........D...p....S..T..F..........A......N.......l.......G....u..GsK.aY.FT-NFY..ARAGV.....E.A.pY..N...I.DpGcs...........E.W.uP..uVGlGVNFGGu.u....................................................................................	0	2	4	11
+5565	PF05737	Collagen_bind		Collagen binding domain	Bateman A	anon	Pfam-B_5000 (release 8.0)	Domain	The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices [1]. A groove on beta-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen.	20.80	20.80	20.80	20.90	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.58	0.71	-3.99	15	1660	2012-10-02 17:35:21	2003-04-07 12:59:11	7	115	482	8	145	1485	0	134.50	19	22.34	CHANGED	ssshaKpGhhDsssss...l+WplslNtshpsl..csAslpDhlssGQsLshsSlclhchshptstpssths............ptssstshtpsssssFplshss...slssuhpIsYpTpIT-tstp......papNpA.....pLssssl-shpss	.............................t...h.Kh.G....hs.....spssp.....lpWp.lslN.......t..s..pppl....pss.slsD.s......h.s......s........s........p.......p....l....s..............s...S.l..p.......l.....hp.s..s.....hsts..t.sh.s.....ht....................s..t...t.hs...s.t.s.s.s.s.....s.a.s.lpatp...........thspuahlpYpT..pl...s...st...s..p................ph.pNpu......ph..st.p........s...........................................................................................	1	80	110	128
+5566	PF05738	Cna_B		Cna protein B-type domain	Bateman A	anon	Pfam-B_366 (release 8.0)	Family	This domain is found in Staphylococcus aureus collagen-binding surface protein.  However, this region does not mediate collagen binding, the Pfam:PF05737 region carries out that function. The structure of the repetitive B-region has been solved [1] and forms a beta sandwich structure.  It is thought that this region forms a stalk in Staphylococcus aureus collagen-binding protein that presents the ligand binding domain away from the bacterial cell surface.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.39	0.72	-4.21	135	13573	2012-10-02 19:08:27	2003-04-07 12:59:11	8	388	1204	80	1267	12494	454	73.40	23	22.10	CHANGED	lpGsphpLhspssssht.......................hsTsssGphphssL......ssGs.YpltEsp.sPsGYphsssshthsht.spt.......ttlp	..........................................................................................ltGspa..pl..h...s..p...s...s.ph.htp..............................................................................hs.T.....s...p..s.....G.....p.....h..p...h...s.....s..L..............................tsG..p...Yplp..E.....s......p...u....P.....s.........G..Y.p.h...s...p...s.s.h...t.h.phtttt..........thh...............................................	0	652	998	1144
+5567	PF05739	SNARE		SNARE domain	Moxon SJ	anon	Pfam-B_6285 (release 8.0)	Family	Most if not all vesicular membrane fusion events in eukaryotic cells are believed to be mediated by a conserved fusion machinery, the SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors] machinery. The SNARE domain is thought to act as a protein-protein interaction module in the assembly of a SNARE protein complex [1].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.79	0.72	-4.28	105	4036	2012-10-03 05:55:03	2003-04-07 12:59:11	14	51	377	62	2609	3820	24	61.80	22	22.43	CHANGED	cpccslpplppslt-Lcplhh-lus.lcpQschlDcI-ssl-pspsplcpuppc..l..pcshphpp	...................ppcpplpplppsltcLpplhh-lup.l..c.p.Qs.c......h.l..Dc.........I-psl-pspsplcpuppc..l...p+shp.................	0	824	1372	2046
+5569	PF05741	zf-nanos	Nanos; 	Nanos RNA binding domain	Moxon SJ	anon	Pfam-B_5908 (release 8.0)	Family	This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localised determinant of posterior pattern. Nanos RNA is localised to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localised source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback [1]. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded  very early in development. The localised and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development [2]. 	21.30	21.30	21.40	23.40	20.90	18.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.26	0.72	-3.99	36	305	2009-01-15 18:05:59	2003-04-07 12:59:11	8	4	133	4	168	260	18	55.30	54	25.74	CHANGED	CsFC+N.............NGEspplYpSHtL...............KDtcG+...VhCPlL.RsYsCPlCGAsGDpA....HTlKYCPhs	....CsFC+p...............NGEuctlYsSHtL...............Ks...cGp...VhCPlL.Rp.Y.sCPlCGAo.G-pA....HTlKYCPh.t...	0	34	47	129
+5570	PF05742	NRDE	DUF833;	NRDE protein	Moxon SJ, Eberhardt R	anon	Pfam-B_6481 (release 8.0)	Family	In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [1]. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit [2]. Swiss:P54797 has been found to be expressed during early embryogenesis in mice [3]. This protein contains a conserved NRDE motif.	20.70	20.70	20.80	20.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.92	0.70	-5.09	12	889	2010-07-12 16:41:27	2003-04-07 12:59:11	7	4	729	0	464	881	260	231.70	27	87.70	CHANGED	MCllhhtapsps....pacLllAuNRDEaasRPoh.ht.Wt.sss.plLuGhDlcp.......uGTWlGlspcG...+huslsNlpps.cp..st..hSRGtLV.s-aLsu.ssss...tpahcpLt...ppupcasG......FNLlhs-hp............clphhoNpsst..h...tLssGhashSNu..cssW.Ksptu+phhtchlt..pssp...ptl.hppLhplhssp...........thhsDspl.ppus.h.php+..h..Louhalc....stpYGTRusTllhVcpcu.csphhERphtspss..........hppschph	............................................................MCllhh...thpsps............th.LllhuNRDEa.....hpR.P..o.t...s..h........t.h.W...............t.......s..............s..............s....p.......l..luGp.Dhps.............GGTWlGl.s..p.p..G.................+hAsLTN..............hp..p......s....t....t...........................s...s................t.SR.GtLl.t.....pa.....L.......p......u....s.ss......................pa.h.pplt.........t.p..s...p.t.....Y..s..G..............................FNLlhu-hp............................t...hhh.....hs.....s.p.st.........t...............................................................l......s.............sG.........h.a..........s..lSN.uh................h.........s.....s.....s........W....Kh.h.t............tpthhtph.lt.............tt..tt........................pthh..thht.sp..........................................................hss....t..t.l.....pp.uh.......thtp...............h.u.s..hh.....lt.................t...YGT.Rspohlh...lp.tp......t....ph.hhEt...h........................h...........................................................................................................................................	1	145	263	376
+5571	PF05743	UEV	Tsg101; 	UEV domain	Moxon SJ, Bateman A	anon	Pfam-B_6022 (release 8.0)	Domain	This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer [1]. This family is related to the ubiquitin conjugating enzymes.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.49	0.71	-4.43	23	474	2012-10-02 15:28:41	2003-04-07 12:59:11	8	17	278	17	281	627	11	113.90	38	28.07	CHANGED	shc-lhsllptap....sLpspscsasa.sDGpsppLLsLpGTIPlpapGss.YNlPlhlWl.csYPh......ssPlsalcPTssM......sI+hsc.aVDspGcl.aLPYLppWsh...sSs.....LlsLlpphts....sFsccsPl	..........................................................hpchhphht.a.....sLp.h.hc..sasa..scGp..sp..Lls..LsG.T.I.PV.ac.Gss...YsIPl..slWl.csYPh...........................sPP.ls.a.V.p...PTssM........hI+...suc...aVDs....s.G.+l...YlPYL..p..p..Wpp..........spSs..............LlsLlphhhs....hFuc-PPl.................................................	0	94	152	221
+5572	PF05744	Benyvirus_P25		Benyvirus P25/P26 protein	Moxon SJ	anon	Pfam-B_6153 (release 8.0)	Family	This family consists of P25 and P26 proteins from the beet necrotic yellow vein viruses.	25.00	25.00	29.20	133.60	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.62	0.70	-5.03	3	211	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	6	0	0	182	0	213.60	72	99.80	CHANGED	DlDphMPVFDlAY.DssHtPYll+RosHEVVhsVussGFICYPL.V..DLNDssslsshlYHN+lKTMRLpVsIpNNcusassFRAhsRFlVFSTPslSsWVNNGCpSLFSPFVGVNSsIDcpLL+RDS+GloVLaDRVY+VsRaT-hF.sVDFThNFRGPGNYsLsNusNaPsATTsDSIYVACVssWlsNsVFRLpSDSVuWVHSGLapGPVL-FGQsL.sAPDcD.DGVsDDG	....MGDILGAVYDLG.....HRPYLARRTVYEDRLILSTHGNICRAI....NLLTHDNRToLVYHNNTKRIRFRGLLCAhHsPYCGFRALCRVMLCSLPRLCDIPINGSRDFVADPTRLDSSVNELLV...SNGLVIHYDRVHcVPlHTDGFEVVDFTTVFRGPGNFLLPNATNFPRPTTTDQVYMVCLVNTV.NCVLRFESELTVWVHSGLYsGDVLDVDNNVIQAP....DGVDDs.....	0	0	0	0
+5573	PF05745	CRPA		Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)	Moxon SJ	anon	Pfam-B_6389 (release 8.0)	Family	This family consists of several Chlamydia 15 kDa cysteine-rich outer membrane proteins which are associated with differentiation of reticulate bodies (RBs) into elementary bodies (EBs) [1].	23.60	23.60	144.20	143.90	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.94	0.71	-4.41	5	37	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	35	0	4	18	0	131.10	62	84.93	CHANGED	MS........ststsu..psllslVpshsup.ulspslpsposslTLlN.llGWs+h+hlpPlRsSKIlpSRAFQITLlVLGIlLVIAGLALhFlLpuQLGsNAFaL.lIPAlIGLVKLLlTSLsM.EcsCTPEKW+LCK+lLtToEDILDDGplNNSNKIF	.....................M...........STVPVVQGAGSS.NSAQDISsposPLTLKp..............RISNLLSSTAFKVGLVVlGLLLVIA..sLlFLVSAASFVNAIYL.uIPAIlGCVNICVGILSM.EGaCSPERWhLCKKlLKTSEDIIDDGQINNSNKVF...	0	1	1	3
+5574	PF05746	DALR_1	tRNA-synt_1d_C; 	DALR anticodon binding domain	Bateman A	anon	Pfam-B_196 (release 8.0)	Domain	This all alpha helical domain is the anticodon binding domain in Arginyl and glycyl tRNA synthetase. This domain is known as the DALR domain after characteristic  conserved amino acids [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.55	0.71	-4.14	104	7484	2012-10-02 19:03:26	2003-04-07 12:59:11	10	22	4857	7	2023	5803	2941	115.90	26	19.29	CHANGED	lQYAaARlpSlh+...+uspth.phttst.hh..............pc.pEhpLhtpLhpFscslppuscp...........hpPchlspYLhcLAstFspFY...p........ps....lls............scpp.h...........puRLtLspsstpsLcpuLpLLGlps.-+M	.......................................................hpYAasRlpuIl+..........Kus..t..p..h......t.h...t.s..ss.hh................................pcs..pEhpL.h.ppltp..asc..hlp..ssspp................................tpPpt...lspY..Lh.c.Lussas.pFY..s...............ps..........hlls......................p-.s..p..t....................psRLs...Lhptstpslp..puh.t.h.l...Glp.s.ppM...................................	0	661	1256	1662
+5576	PF05748	Rubella_E1		Rubella membrane glycoprotein E1	Moxon SJ	anon	Pfam-B_6726 (release 8.0)	Family	Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus.  The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins. The E1 has been shown to be a type 1 membrane protein, rich in cysteine residues with extensive intramolecular disulfide bonds [1].	25.00	25.00	89.80	89.70	18.90	16.00	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.81	0.70	-5.89	2	838	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	11	0	0	460	0	312.50	94	88.37	CHANGED	LTAVVLQGYNPPAYGEEAFTYLCTAPGCATQsPVPVRLAGVRFESKIVDGGCFAPWDLEATGACICEIPTDVSCEGLGAWVPAAPCARIWNGTQRACThWAVNAYSSGGYAQLASYFNPGGSYYKQYHPTAC-VEPAFGHSDAACWGFPTDTVMSVFALASYVQHPcKTVRVKFHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQSRWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTVRPVALPRsLAPPRNVRVTGCYQCGTPALVEGLAPGGGNCHLTVNGEDlGAhPPGKFVTAALLNTPPPYQVSCGGESDRAoARVIDPAAQSFTGVVYGTHTTAVSETRQTWAEWAAAHWWQLTLGAICAL.LAGLLACCAKCLYYLRGAIAPR	..............................................................................................................................................................................FHTETRTVWQLSVAGVSCNVTTEHPFCNTPHGQLEVQVPPDPGDLVEYIMNYTGNQQSRWGLGSPNCHGPDWASPVCQRHSPDCSRLVGATPERPRLRLVDADDPLLRTAPGPGEVWVTPVIGSQARKCGLHIRAGPYGHATVEMPEWIHAHTTSDPWHPPGPLGLKFKTV.RPVsLPRALAPPRNVRVTGCYQCGTPA.LV...EGLAPGGGNCHLTVNGEDVGAFPPGKFVTAALLNTPPPYQVSCGGE..................................................................................	0	0	0	0
+5577	PF05749	Rubella_E2		Rubella membrane glycoprotein E2	Moxon SJ	anon	Pfam-B_6726 (release 8.0)	Family	Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus.  The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58 kDa) and E2 (42-46 kDa).  In virus infected cells, RV matures by budding either at the plasma membrane, or at the internal membranes depending on the cell type and enters adjacent uninfected cells by a membrane fusion process in the endosome, directed by E1-E2 heterodimers. The heterodimer formation is crucial for E1 transport out of the endoplasmic reticulum to the Golgi and plasma membrane. In RV E1, a cysteine at position 82 is crucial for the E1-E2 heterodimer formation and cell surface expression of the two proteins [1].	19.30	19.30	19.40	594.70	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-12.04	0.70	-5.15	3	68	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	10	0	0	85	0	267.00	97	26.88	CHANGED	GLQPRADMAAPPsPPQPPRAHGQHYGHHHHQLPFLGHDGHHGGTLRVGQHHRNASDVLPGHWLQGGWGCYNLSDWHQGTHVCHTKHMDFWCVEHDRPPPATPTPLTTAANSTTAATPATAPAPCHAGLNDSCGGFLSGCGPMRLRHGADTRCGRLICGLSTTAQYPPTRFGCAMRWGLPPWELVVLTARPEDGWTCRGVPAHPGTRCPELVSPMGRATCSPASALWLATANALSLDHALAAFVLLVPWVLIFMVCRRACRRRGAAAA	GLQPRADMAAPPsPPQPPRAHGQHYGHHHHQLPFLGHDGHHGGTLRVGQHHRNASDVLPGHWLQGGWGCYNLSDWHQGTHVCHTKHMDFWCVEHDRPPPATPTPLTTAANoTTAATPATAPAPCHAGLNDSCGGFLSGCGPMRLRHGADTRCGRLICGLSTTAQYPPTRFGCAMRWGLPPWELVVLTARPEDGWTCRGVPAHPGTRCPELVSPMGRATCSPASALWLATANALSLDHALAAhVLLVPWVLIFMVCRRACRRRGAAAA	2	0	0	0
+5578	PF05750	Rubella_Capsid		Rubella capsid protein	Moxon SJ	anon	Pfam-B_6726 (release 8.0)	Family	Rubella virus is an enveloped positive-strand RNA virus of the family Togaviridae. Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly,  the capsid interacts with genomic RNA to form nucleocapsids. It has been discovered that capsid phosphorylation serves to negatively regulate binding of viral genomic RNA. This may delay the initiation of nucleocapsid assembly until sufficient amounts of virus glycoproteins accumulate at the budding site and/or prevent non-specific binding to cellular RNA when levels of genomic RNA are low. It follows that at a late stage in replication, the capsid may undergo dephosphorylation before nucleocapsid assembly occurs [1].	25.00	25.00	25.20	25.20	17.10	16.40	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-12.05	0.70	-5.02	3	110	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	10	0	0	117	0	208.20	97	34.49	CHANGED	MASTTPITMEDLQKALEAQSRALRAELAAGASQSRRPRPPRQRDSSTSGDDSGRDSGGPRRRRGNRGRGQRKDWSRAPPPPEERQESRSQTPAPKPSRAPPQQPQPPRMQTGRGGSAPRPELGPPTNPFQAAVARGLRPPLHDPDTEAPTEACVTSWLWSEGEGAVFYRVDLHFTNLGTPPLDEDGRWDPALMYNPCGPEPPAHVVRAYNQPAGDVRGVWGKGERTYAEQDFRVGGTRWHRLLRMPVRGLDGDSAPLPPHTTERIETRSARHPWRIRFGAPQAFLAGLLLAAVAVGTARA	MASTTPITMEDLQKALEAQSRALRAELAAGASQSRRPRPPRQRDSSTSGDDSGRDSGGPRRRRGNRGRGQRRDWSRAPPPPEERQESRSQTPAPKPSRAPPQQPQP...................................................................................................................................................................................................	0	0	0	0
+5579	PF05751	FixH		FixH	Moxon SJ	anon	Pfam-B_6803 (release 8.0)	Family	This family consists of several Rhizobium FixH like proteins. It has been suggested that suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalysed by FixG [1].	21.90	21.90	22.40	22.20	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.71	0.71	-4.38	118	910	2012-10-01 19:30:51	2003-04-07 12:59:11	6	3	891	0	266	726	75	141.60	21	86.55	CHANGED	+phhsa....hllshhusllssslshhhhAhsshs.uLVs-shYctupshstpl.....sctcttpsLGhp.splphss..........splplpl...tpGtP.htstplshplh+PTpsppDh.shhls...tsssG..hYpu...h.....hpGpWplcl................pssspta+hptclh	.......................thasa.......hllhhh..hsllhsslshl.h...lA.h..p.s.....s...slVs...-sY....Y.cpu.pshs.t.ph.....sph.p.t..tp.p.hshp..sp.l.phps..............................sthplph....tpu.....ts......sp..tlp.lhhh+P...sp.....tp.....pD.......h...pl.lp........tsG.......haps.shpt...........hpG.pW.lcl................p..t.st.ah......h..........................................	0	74	168	218
+5580	PF05752	Calici_MSP	Calicivirus_MSP; 	Calicivirus minor structural protein	Moxon SJ	anon	Pfam-B_6811 (release 8.0)	Family	This family consists of minor structural proteins largely from human calicivirus isolates. Human calicivirus causes gastroenteritis [1]. The function of this family is unknown.	21.20	21.20	21.20	72.00	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.07	0.71	-4.65	14	126	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	121	0	0	88	0	165.00	49	99.90	CHANGED	MSWhsGALtsuGSLVDhAGTISsIVhQQRQls.h....pcQNcl.pcWhs+QEsLQcct.-lo+-LulpGPstRVpuAlsAGFsslsARRLAGSsERVhYGhLDRPIhptushpu.IppT+HLpshpuALosFKpGTs.aGpPsPPphthspPt.pssssplNL.GasPsSSsl	..........MSWLVGALQssGuLVDhAGTVSsIVYQpRQls.L....cpQNpLhpsWMsKQEtLQ+ctM-Loc-LulNGPAhRVpuAl-AGFDsVSARRLAGSuERVIaGhLDpPIhptsshsu.lppTpHLsslsuuLuTFKpGTs.FGp.PsP....Pp.h.psGsPt....pss.sP.plNl.GapPGSSss........	0	0	0	0
+5581	PF05753	TRAP_beta		Translocon-associated protein beta (TRAPB)	Moxon SJ	anon	Pfam-B_6857 (release 8.0)	Family	This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion [1].	21.60	21.60	21.60	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.08	0.71	-5.12	22	254	2012-10-03 16:25:20	2003-04-07 12:59:11	9	7	174	0	139	284	8	166.30	32	74.51	CHANGED	hh.hh.lhhhhs.shupp-s........sARlLspKplLscahVpsc-lsVpYsIaNlGsusAhcVplsD.suF.stcsFplVuG..phosph-plsPsssloHshllcP+p.GhFshouApVoY.....+ssccssphQhuho..ot.upssIlup+shs+pFost....hh-WhuFushshsshsl.....PhhlaasSKspYpth.pK	..............................hh....h.hhhl.hh.h.shsps-p............sAtllspKpl.Ls+.hhVtuc-lslpaslYNhGsu.sAh-Vpl.sD...sua....s......s-sF.......pl.Vu...G..........hshph.-.RlsP..u..u.sl....oH.shVlc.P.pp.hGhFshosAploY......hsppp.....st.l.t.huho........os.sthsIls.+th.s++Fs.t............hhcahshsshsh.shhh.....shhlh..SKpphtt....tt...................................................................	0	45	68	105
+5582	PF05754	DUF834		Domain of unknown function (DUF834)	Bateman A	anon	Pfam-B_9258 (release 8.0)	Domain	This short presumed domain is found in a large number of hypothetical plant proteins. The domain is quite rich in conserved glycine residues.\	 It occurs in some putative transposons but currently has no known function.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.25	0.72	-4.17	18	515	2009-01-15 18:05:59	2003-04-07 12:59:11	9	34	5	0	411	501	0	64.80	32	26.11	CHANGED	psssssshpsTspsscpssuscpsGuss.RlDsDsGAPsVsGpstGADElscssA+shssss.ocuDstssG	........................................t...........s.sttptstscp..uG..GusR..l.Ds...ssGsPAV...s..spstusDclstssAcPptsss.p....p...tcs.tuss....................	0	0	0	12
+5583	PF05755	REF		Rubber elongation factor protein (REF)	Moxon SJ	anon	Pfam-B_6903 (release 8.0)	Family	This family consists of the highly related rubber elongation factor (REF), small rubber particle protein (SRPP) and stress-related protein (SRP) sequences. REF and SRPP are released from the rubber particle membrane into the cytosol during osmotic lysis of the sedimentable organelles (lutoids). The exact function of this family is unknown [1]. 	25.00	25.00	26.50	26.30	22.20	21.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.33	0.70	-4.59	10	99	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	31	0	41	94	0	182.90	39	85.39	CHANGED	-pspsEEc+...LKYL-FVQsAAlYslssFSsLYtaAKDpSGPLKPGV-sVEusVKsVVuPVYpKFasVPh-lLKFlD+KV-soVp-LDR+VPPlVKpASuQAhohh..hs.hs.tlAsEVppsGlhtsAp.......shspshhs+......tLhspYEPhAEphAVpsW+tLNpLPLhPpVAplslPTAAahSEKYNcsVshsu-+GYsVAsYLPLlPTE+IuKVFtc-s	..................................t...ptpptc...LKaLtFVphAuhpshh....thuslYtaAKcpu.GPL.+sGVpsVEssV+sVluPVYp+FcslP.-lLtFlD+KVD-slpc....lDc+lPs.....hlKpssspAhshhptss.............s.tlsuEsppsGshtssp......................................lhscaEs.hA.tp.hulpsWptLNphPhhPpVsphslPsAAahoEKYNpslhshsc+GYthstYLPllPhEcIu+sFt...t.................	0	4	29	35
+5584	PF05756	S-antigen		S-antigen protein	Bateman A	anon	Pfam-B_7194 (release 8.0)	Family	S-antigens are heat stable proteins that are found in the blood of individuals infected with malaria [1].	25.00	25.00	92.00	91.90	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.27	0.72	-4.01	4	57	2009-09-15 09:48:53	2003-04-07 12:59:11	6	1	6	0	1	58	0	62.60	79	62.61	CHANGED	MNRILSVoFYLFFlYLYIYKTYGKVKNTDcELSNIYGsKYYLRsGhhNpKNGKGpKYEDLpEEtEGENDDEEDSNSEESsNDEENtLIEGQspu	.......VoFYLFFlYLYIYKTYGKVKNTDpELSNIYGTKYYLRsGhFNcKNGKGpKYEDLEEE..................................	0	1	1	1
+5585	PF05757	PsbQ		Oxygen evolving enhancer protein 3 (PsbQ)	Moxon SJ	anon	Pfam-B_6905 (release 8.0)	Family	This family consists of the plant specific oxygen evolving enhancer protein 3 (PsbQ). Photosystem II (PSII)1 is a pigment-protein complex, which consists of at least 25 different protein subunits, at present denoted PsbA-Z according to the genes that encode them. PsbQ plays an important role in the lumenal oxygen-evolving activity of PSII from higher plants and green algae [1]. 	25.30	25.30	25.30	25.50	24.90	25.20	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.07	0.71	-4.90	18	175	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	69	5	82	172	2	161.80	26	81.35	CHANGED	phsssusspssstRusls....lRAst.........t.t..pssRRAllG.LlAsulsuuuhspAshAs.........sh.htlshssP.sushsGs.spspARDhpLs.lKcR......FaltsLuPs..EAAtRsKcSAp-I.lsl+shI-+Ks..WsaVpspLRL+uuY..LRaDLsTllSuKP.c-cKpsLh-Ls.scLFpsl-sLDaAs+pKsss-ApKaYtcThssLs-VLApLu	..............................................................................................ht.................................................................................................................ts+sh.....t.t......hh...hsst..tshtRh+psApcl.hslcs..h....I...-ccs...WshlpptLRh+uua..L+hDLpsl....Isu.p.P.c..cc.+pslpcLs.scLFsslscLDhAs..+pKssspspphYtpshpsLs-lluhh...........................................................	0	20	52	70
+5586	PF05758	Ycf1		Ycf1	Bateman A	anon	Pfam-B_6040 (release 8.0)	Family	The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. Although the function of Ycf1 is unknown, it is known to be an essential gene [1].	29.20	29.20	29.40	29.40	28.40	29.10	hmmbuild  -o /dev/null HMM SEED	929	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.64	0.70	-13.90	0.70	-6.83	44	1439	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	1082	0	33	1491	2	450.30	52	62.57	CHANGED	SVVlVGLYYGFLTTFSIGPSYLFLLRAplh..........EEGTEKc.............lSATT.GFIsGQLhhFISIYYuPLHLALGRPHTITVLsLPYLLF+..FFasN.pK...cFh..sasp...sspNSh...RNhsIQslFLNNLIF.QLhNhhILPSShLsRLVNIYhFRCNNKhLFVTSSFlGWLIGHILFhKWlt.....LlLhWIc.........p.NpS.................Icp...........Ipss......KY..LVscltN.h...+I.....................................................................FSILLFIoClaYLGRhPs.PlhTKKL..pp...............................................schcct........ccppphch-p..ct.....ttscpcpchs.tpps......lh..ccpts.pp.........................................................................................................................p.hp.......pp........phhhF.cKPllTlLFDYcRWNRPhRYI...K.Ns+F-..ssV...RsEhSQYFFtTCpSDGKpRISFTYPPSLSTFh-MI.p++ls.....lhshcK.h...s--.....LYsp...WlhoNcpK+ssLssEFlNRIcsLD+u.....lh........................h-lLEp..RoRL..C..sscscpc.........hLsKh.....................YDPhLNGsaRGp...............I..cchhSss...............................l......hsc...s.hcs.hcphh.....lN+laslLh............sssapchEpc......s..........hcslspph...h..........l.p.s.p...............................................................................................................................................t.p....l........tph.........pppppphhphlhshlhss..pppph.p....cs...................................ltI.pEIp......KKVPRW...SYKLhs-......lEptct-...cp...sst-ppIRSRKsK.+V....llhss.......pp...tp.................................................................................................................................................................................pcptc..-...hslhRY.SQQSDFRRclIKGSMRAQRRKslIWchFQsslHSPL.......FLD+h-Kh...hhF.sF..slsphhc........................hla+..........sa..hp.Kppchch.s...pccphpc.............Kppc.ph.....pcpcRlp.IAEtWDsl.hAQhlRGhlLlsQShLRKYIlLPsLIIuKNIuRlLLFQhPEWsEDac-WsREhHlKCTYNGlpLSEs....EFPcsWLpDGIQIKILFPFpLKPWHcSKhp.........................t.p...hpcpt.c+c................................................................sF..CFLTVWGhET-lPF.GsP+KpP....SFFcPIh	......................................................................................................................................SVVVVGLYYGFLTT..FSIGPSYLFLLRA+VM..........EEGTEKc.............VSATT.GFIsGQLMMFISIYYAPLHLALGRPHTITVLsLPYLLFH..hF....hNN....pp.....p.hh.............s.GS............TT.RNSM..........RNL.SI...QCV.......FLNNLIF.QLFNH.F.I.LPSSsLARLVNIYMFRC.NNphLFlTSSFVGW.LIGHIL...F.MK.WhG.......LV.LhWIc.........pNs........................................IcSN........................................................KY..LVSELR.NsMs..RI...................................................................................FS..ILLFlTC.VYYLG..Rh.PS.PlhTKKL...KEs..........................................................................................................................................SchEEh.............ctcpcsc..lEss..Eh.......ctspp-.pct...tpp.........................t..........pp........h..............................................................................................................................................................................hp.t...p.p.cs....ch.thhcp...................ph.h.a...h.....-K....sh.lThhFsacRWNRPhRYI....t............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	26	30
+5588	PF05760	IER		Immediate early response protein (IER)	Moxon SJ	anon	Pfam-B_6450 (release 8.0)	Family	This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it  play an important role in mediating the cellular response to mitogenic signals [1,2]. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals [3,4].	21.70	21.70	27.70	23.40	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.20	0.70	-4.49	10	171	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	48	0	78	166	0	176.10	27	97.89	CHANGED	MEstl-AQpllSISLtKIaNSRsQRGGIKLHKNLLVShVLRsARQlYLS-+YutlYhttpttpstsssspp........................................................................................susstlpPPSutt........................................lsspspSP-....sss-P....u.hpsssucs.ssust..sssssGs.psspsosLDhsocVlTTVEsuhLpp............................................sCss..p.u.t.t.spsssspRKhpsuuhtS-uucss...........uhsPs.KRuRhE-.sspshu-sp-up.........puNloNLISIFGSuFSGLLS+pssusps...hstp..........hCsKpALusLusWoRAIVAF	...........................................................hth-ApplhslSlhKhhpSRhQRGGl+LH+sL.lohVhRsARp......l......Yhst........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	10	18	33
+5589	PF05761	5_nucleotid	5_nucleotidase; 	5' nucleotidase family	Bateman A	anon	Pfam-B_2948 (release 8.0)	Family	This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.	27.00	27.00	27.40	27.30	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.40	0.70	-5.97	21	680	2012-10-03 04:19:28	2003-04-07 12:59:11	9	8	168	12	393	595	21	368.90	30	81.95	CHANGED	lFsNRsLsLcsIchaGFDMDYTLAhYps.phEpLuF-hsh-+Lls.hGYPpslh.phpYDPpFslRGLhhDptpGNLlKlDtaGplt..ssaHGhc.Lss-Elt-hYssp.plphcpst..........pathlsTLFuLPEssLhAslV-ahp......................................sss.hphsappLacDV+cAlDpVHhcGpLKpclhpclp+Ylh+DsclshhLp+L+psGKKLFLlTNSsasYsDthMsYlhst..s..........sWRshFDlVIVsAcKPtFFs-sp.PhRplDscsGpLphsp................hssLc+G.........plYpGGsh.phpclhGh+.GsclLYlGDHIauDlhcoKKppGWRTshll.ELccElclhsscptthsp..LppLpslhsclpsphs...................................ctsshpt.slpphppchcplppshcphFN..aGuLF+s.GsppohFupQlpRYADlYsoplsNhLpYssthhF+us+s..hhPHEsss.ps	...................................lasspphphpplp...hhGFDhDYTLs.Yp..th.ctLhaphshchLl.p..htYP.pp..lh..p..h.p...a.-.s.s..Fs.h.R...GL...hhDh.hG.LlKlDt.at.l....hsh+G.h.p.l........tt.p.......-l.hchYssp..hl...ht.t.p..................phh..h.slFslP.EhhLhupll-hht..............................................................................p...t...p..h..h.s.....hphapD...V..p...s......Al......p...s....H.......h.......p..........G.............hh.......p.......t.......h.......h.......ps.p....+Yl...p.s.s.p.h...hhLpc........hpp.t.G.t.......p..lFLlTN.Ssapass..thMpa.....h.hs..................sWpshFDlllspAp...........KP.....tFFs...c...tp...sh+pl.s......pp..u.t....h...t....hs.p.................................................h.t...lp..pG................tlY...pt......G...sh.....t....h....h....c....l.............h........s.....h...c......G....p.....c......l..LY.hGDHlauDl..hpsph.t..puWRThhl..l.ELt..p..Elphhtppp...h.t...httLp...htph......................................................................................................................................p.tt....htt..h.tphp.h....t.h.p..as...hG.hh+s...p.ohF..pl.+auslYhuph.shh...a...hhahs........h.Hc.....s........................................................................	0	140	203	293
+5590	PF05762	VWA_CoxE	vwa_CoxE; 	VWA domain containing CoxE-like protein	Bateman A	anon	Pfam-B_2956 (release 8.0)	Family	This family is annotated by SMART as containing a VWA (von Willebrand factor type A) domain.  The exact function of this family is unknown.  It is found as part of a CO oxidising (Cox) system operon is several bacteria [1].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.30	0.70	-5.21	17	2445	2012-10-10 16:07:06	2003-04-07 12:59:11	9	3	1560	0	642	2460	867	184.40	23	42.62	CHANGED	Ltctltt....hhhthstcR...ph.spt+st+lDh++TlRtslpputp..........hthhh+p..Rppcs.clVlLlDlSGSMptaoshahtlhpAlhtsht..cschFsFuTplsclTptl.pttDsspuLhcs..p..h...huGGTcIupuLtphtphhstps...tusVlllSD.....uh-psshstLtpplscLppput+llhLsPh..tthsuacsp.stulcAhhspV.sthtPscphpsl	................................................................................h.................h..h.....t..h..........t..tphDh..p..tTl..p.....t..s.h...t..p..hh...................................h.h...tp........+..p...s....p...s........p.lll..hlDsSG.SM.........s...........s...........a..........s.........t.......h..........t.......h......t.......l....h..p.....u.......s.....h..s...p.hp..........+s.cl.h..h...F.s....T...p......l.......s.......c..........h..........p.........t......h.......s.....................s..........p..h...l......h.hh.........p..........ht.......G.G.............T....c.......lu....p.sh.t....h....h..h......p..h...h......t....t..........t...............p...s...s.....h..lllSD........h.h..t..t....t............s....h...h...p...p...l.t.c...h....p.....t.+..hhh....hss.......thsth.................................h...........................................................................................................	0	197	410	528
+5591	PF05763	DUF835		Protein of unknown function (DUF835)	Bateman A	anon	Pfam-B_3039 (release 8.0)	Family	The members of this archaebacterial protein family are around 250-300 amino acid residues in length. The function of these proteins is not known.	28.10	28.10	28.80	37.30	26.90	28.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.79	0.71	-4.61	38	148	2009-01-15 18:05:59	2003-04-07 12:59:11	7	16	24	0	116	168	35	135.30	25	39.06	CHANGED	G.uhhhsspp......hhthlcsh.p....sslsloRp...sPcpact.........lhWlT+sp...uc..s.....ulsPTpLthlh-hlhcalcp..tss....lVllDsLEYLlL.NGFculhKFLtsLKDhslhpsut.lIlhsc.cuhs-+-hslLc+Ehp	..............................p.....hh.hlpp.h.pth...ssLsloRp...sPcphp........th.hlWlopsp...sc....p........slsPopLt.hlhch.lhcalcp.ttps.....lVllDslEYLll.NG....FcslhKFLtsL+Dhs.lhpsuh.lllsl-.pslsc+phslLpRph........................	0	19	27	73
+5592	PF05764	YL1		YL1 nuclear protein	Bateman A	anon	Pfam-B_3088 (release 8.0)	Family	The proteins in this family are designated YL1 [1]. These proteins have been shown to be DNA-binding and may be a transcription factor [1].	29.00	29.00	32.00	29.70	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.92	0.70	-4.76	37	325	2009-01-15 18:05:59	2003-04-07 12:59:11	8	7	271	0	234	329	1	213.70	27	44.43	CHANGED	htsRs+RusAGp+hppLLptE.-t--...pp...................hFpE---DpEaptppp-ppp................................................................Dsshsssp.s-...........cssss--t-uE+t.....ptcc..+++hhtpcthhc.hh...........h+h+h..............................phps.sssc.c.....tpppc.p.h.ohhss........tRpSsRpoThpppptsht+Lp-p-t+Rtph.t......t+++tptpp+thTQEE+LtEAccTEchNh+SLp+acchEtpKKc......pshpp+ph.pGPhlpahSst	................................................................sRspRssAGp+hpp.LLptE.c.p..D-h..t..t............................hFp.E..-..ps...D.c-aptppp-p-s..............................................Ds-hsps-.s-.............psssss-t-tc+...........................++.+..hhh.ppth..htsht............h+hph......................................................t.pt.tt.t.p............t.p..p.tp........h.s.ht..........................tRpShRposh...p.pt.th..+.h...pcppt.....pc..ht.......................tp+ct..t....tppc.hTQEEhLtEA.t..TEchNhcSL...ppapch.Etc+Kc........pshtp+t..h.tGPhlpahSh.s.............................................................................	0	76	128	195
+5594	PF05766	NinG		Bacteriophage Lambda NinG protein	Moxon SJ	anon	Pfam-B_7000 (release 8.0)	Family	NinG or Rap is involved in recombination. Rap (recombination adept with plasmid) increases lambda-by-plasmid recombination catalysed by Escherichia coli's RecBCD pathway [1].	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.48	0.71	-4.55	19	590	2012-10-05 18:28:12	2003-04-07 12:59:11	7	4	389	0	37	440	99	170.90	48	96.91	CHANGED	h..+ps+.+KCK..sCsshFsP.tpshQ.pVCSscCu......hthtp.....tppccpc+ptpptERpcl+tRKc+LK..s+u-ah+-sQtshNcalR.hRDh..shPCISC.......Gp...........hpsupacAGHYRosGAsspLRFp..NlHpQCshCNpahS.....GNlls..YRhsLlc+IGhEcVEhLE.usHpspKasI-EL+plpshY+uKh+cLc+......cuA	..........................................tp..cR+CK...CtphFhP.hht....sQ.hh...C.s..ppu............hth.tc.........ttpttcc..cp+...ppcpcp+c..ch+h+Kh...slK..s+u.hWl.+.p.AQpAhNtaIR..pR.....Dt.........s..hs....CISC.......Gs...........hp.u.up..aDAGHYRosuAsP....pLRFsEpNlHpQCs.sC.Np+.KS.......GNlVs...YR..lp..LIs...R...IGp...EAV-plE.....uNHst+RWTlEE..h+uIKucYppKLKcL+p.....uct........................................	0	3	14	26
+5595	PF05767	Pox_A14		Poxvirus virion envelope protein A14	Moxon SJ	anon	Pfam-B_7009 (release 8.0)	Family	This family consists of several Poxvirus virion envelope protein A14 like sequences. A14 is a component of the virion membrane and has been found to be an H1 phosphatase substrate in vivo and in vitro. A14 is hyperphosphorylated on serine residues in the absence of H1 expression [1].	25.00	25.00	25.00	25.80	23.60	23.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.19	0.72	-4.03	9	50	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	42	0	1	25	0	89.70	60	99.01	CHANGED	MDhhthlpNhaSslllsGIlLLhsACIFAFl-FSKsspss-.sWRALSllsFIlGhllllGhllaohYsRaCt...sosshcssRh.Nso-IELs	..MDhMhhIuNYFS.GVLIuGIILLllSCIFAFIDFSKsT.u.P.Tc.TW+sLSIhuFILGIlITlGMLIYSMWG++CsP..sSsVIcs.....NpSDIplN..............	0	0	0	0
+5596	PF05768	DUF836		Glutaredoxin-like domain (DUF836)	Moxon SJ, Bateman A	anon	Pfam-B_7010 (release 8.0) & Pfam-B_2829 (release 14.0)	Domain	These proteins are related to the Pfam:PF00462 family.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-10.03	0.72	-3.72	48	1303	2012-10-03 14:45:55	2003-04-07 12:59:11	9	7	1259	7	450	2272	1309	77.50	25	77.65	CHANGED	plhLau+ssCsLC-.......thpphLpt...hthptt.........hplphlDIs.....ssss..Lhp......................+Ys.clPVlthss............................tthhphtlst-pLtphLp	...............lhLa.s+t.sC.tLC-.......pspph.Lpt......l.t..t.chs.....................hplph.l...DIs.........psss........Lhp.........................cYs...........c...l.P.V.lhhss.............................tphhha.hctppLpt.l.h....................................................	0	104	261	371
+5597	PF05769	DUF837		Protein of unknown function (DUF837)	Moxon SJ	anon	Pfam-B_7035 (release 8.0)	Family	This family consists of several eukaryotic proteins of unknown function. One of the family members (Swiss:O02197) is a circulating cathodic antigen (CCA) found in Schistosoma mansoni (Blood fluke) [1].	21.30	21.30	21.40	21.30	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.23	0.71	-4.75	9	231	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	103	0	133	212	1	152.70	36	73.36	CHANGED	MosTl-plLhDAKslspRL+-+Dshu-sLl-potslp+pVcuM+........pYQE-hp.lpclu+.+sp....hhlpQENpQI+-LQQEN+EL+soLEEHQpALELIMuKYREphhphhhspKhs.sEhhhp...hpcphsp.lpsQh-+IsEMusVM+cAlplD-pphspppEplspLchENctLR-lLpIS+p	....................................................................shohpphlhDA+tLhpRL+-p-stu-sLlppstslpppl.t......uh+......................papE-h.p.p.l.pchuc...+sc.........hhlppE..Npp.l....c-LQpEN+...........ELphuLEEHQpALELIMsKYR....c...phh....plh.hsp+..h...t...s.t.hht..........h.p.....pp....p...sp.lptp....hc.pIpE....MutVMppAhp...hD-pp...t.p..pphl..pL.p.ENptLRchLtIsp...................................................	1	38	46	78
+5598	PF05770	Ins134_P3_kin		Inositol 1, 3, 4-trisphosphate 5/6-kinase	Moxon SJ	anon	Pfam-B_7042 (release 8.0)	Family	This family consists of several inositol 1, 3, 4-trisphosphate 5/6-kinase proteins. Inositol 1,3,4-trisphosphate is at a branch point in inositol phosphate metabolism. It is dephosphorylated by specific phosphatases to either inositol 3,4-bisphosphate or inositol 1,3-bisphosphate. Alternatively, it is phosphorylated to inositol 1,3,4,6-tetrakisphosphate or inositol 1,3,4,5-tetrakisphosphate by inositol trisphosphate 5/6-kinase [1].	20.20	20.20	20.20	21.70	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.04	0.70	-5.41	5	297	2012-10-10 13:17:03	2003-04-07 12:59:11	6	6	113	8	186	306	8	257.30	33	79.58	CHANGED	usshp+RhlVGYALosKKlKSFlQPuLluLARpRGI-lVslD.oRPLsEQGPFDlIIHKLhD............cEW+cpL-EFR-AHP-VsVLDPPcAIc+LHNRpSMLQlVu-Lcl...uscscRlGlPcQlVlhpD.uuulsculspAGL+FPLIAKPLVADGTAKSHEMSLlYcQEGLptLcPPLVLQEFVNHGGVLFKVYVVGEsl+VV+RhSLPDVSpccL..ssucGsFsFspVSsssuou-......-sEl..Dh..ulAEhPPcslLc-LA+ALRRuLGL+LFNFDlIR-spstDRYhVIDINYFPGYuKMPuYEsVLTDFlho	........................................................................................................................hhh..t+.tph.....th....s........ttp.sh...hl.ls...phslt..pQ..G..s.h.DlllHKlh.s..........................................................thh.pthp..cahp.t..HPps.hl.lDP..uIpp.........LhsR.p.hphl.t.c....lph...............t......tt.......p.....l.t.......s.P...h.....lp.....p.......s.......t......sh.....p.h...lt......ps..........uLphPh.lsKshV...Ac...Go.p..SHcMullas........p.cu.L.........p...t........l......p.....s.........P....h...........V..lQ.pFlNHsullaKVaVlG-ph.ps.VpR.SL....s..hs..t.t..p........sp.t..t....h.hh....p....tp.....l.Sp.ts..ss...........................tth....-............t..........hp.h..P...s.t....t....h.....l.....pp.....luptLRptLGlp.LFs.hDlI........h...............pt..t........s.............s..........p.a.hlIDlNhFP...G.............atthsta.t.hhphh..p.........................................	0	71	119	151
+5599	PF05771	Pox_A31		Poxvirus A31 protein	Moxon SJ	anon	Pfam-B_7044 (release 8.0)	Family	\N	22.40	22.40	23.20	66.00	20.80	19.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.49	0.71	-4.28	6	59	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	30	0	0	49	0	112.70	75	84.00	CHANGED	M.-IFphL+.hE+phFsshslslPKcKpshsaKshsFIFYpPKcsplp+YlssuslaHoDhlVhGKVlIsshKhLLhYMDLpYYGlohsGshY+LGpSIccLSLcppKlhs+hot	Ms.SILNTLRFLEKTSFYNCNDSITKEKI.KIKHKGMSFVFYKPKHSTVVKYLSGGGIYHDDLVVLGKVTINDLKMMLFYMDLSYHGVTSSGsIYKLGSSIDRLSL.NRTIVTKVN.N......	0	0	0	0
+5600	PF05772	NinB		NinB protein	Bateman A	anon	Pfam-B_4884 (release 8.0)	Family	The ninR region of phage lambda contains two recombination genes, orf (ninB) and rap (ninG), that have roles when the RecF and RecBCD recombination pathways of E. coli, respectively, operate on phage lambda.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.49	0.71	-4.49	13	563	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	435	2	37	310	28	118.00	46	85.64	CHANGED	hLRspph+pNAlphIpplPsDscKPlVlpIp-tTRoLpQNu+hWAhLsDlScQV.WaG++LssEsWKslFsuuh....tpcp-slPGL-G.thVslGpSTu+MoVpcMu-LIEhlpAaGsppGV+aoD	..............................lRs.thppNAIpAl.pl.......Ds......ppPl..hlpIp..-.....p..RolcQNp+hW.A.hLsDlSR.QV.W....H.......Gc....hLssEs.WKslFTAuh..........t............p.....Q............cslPG......l........-G.GhV.....hlG.psTS+MpVuchsELIElhtuFGs.E+.G..V+aSD.................................	0	2	15	21
+5601	PF05773	RWD		RWD domain	Bateman A	anon	Pfam-B_3991 (release 8.0)	Domain	This domain was identified in WD40 repeat proteins and Ring finger domain proteins [1]. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain [1] after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null --hand HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.71	0.71	-4.18	119	1878	2012-10-02 15:28:41	2003-04-07 12:59:11	17	79	325	8	1276	2204	23	119.30	20	19.67	CHANGED	psp-.pppEl-uLpuIYs-ch....................................hpppsstphplpl........................................................ptt.sphs............................................................................slpLphphsp...sYP.ppsPt.lp...lpsstttt...........................................tphpplpppLpchhppth.....G.pshlaslhphlp-..hl	...............................................................................................................................................................................................................................................................ctpppElcsLpu..I.Y..scph..............................................................................htpt.s.s..p..h.p....lpl.................................................................tt.ttsthh..................................................................................................................................................................................................................................................sl..p..Lp..l..p.....hPp.......sY..P..p......psPh..lp.....lpsttthp...............................................tphp.p..l.tppLpphhppth.....G..psh.lasllphlp-..h...............................................................................................	0	383	606	961
+5602	PF05774	Herpes_heli_pri		Herpesvirus helicase-primase complex component	Moxon SJ	anon	Pfam-B_7045 (release 8.0)	Family	This family consists of several helicase-primase complex components from the Gammaherpesviruses.	25.00	25.00	53.10	50.20	21.00	18.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.59	0.71	-4.15	8	24	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	19	0	0	23	0	125.00	30	37.95	CHANGED	Wl-oLphslsLhh...ssps.psILcslLslhassRcsTsFWLLPpualpptsppPslPhDCluPp.halhTcsGshp.Whs-asLPsslsYpsYlppllclhphlp.t..sstpscph..hL-sapplLsLF	..WlssLshslslhh...ssho.tsllcpllslhappR+sosFWLlPpsaspthshp.PslPhDCluPp.halhTpsGshp.WhtshsLPsslsYthYlpphlclhphl.........ssppscphp.hL-tapplLsLF................	0	0	0	0
+5603	PF05775	AfaD		Enterobacteria AfaD invasin protein	Moxon SJ	anon	Pfam-B_7107 (release 8.0)	Family	This family consists of several AfaD and related proteins from Escherichia coli and Salmonella bacteria. The afa gene clusters encode an afimbrial adhesive sheath produced by Escherichia coli. The adhesive sheath is composed of two proteins, AfaD and AfaE, which are independently exposed at the bacterial cell surface.  AfaE is required for bacterial adhesion to HeLa cells and AfaD for the uptake of adherent bacteria into these cells [1]. 	21.50	21.50	22.50	34.00	20.00	21.40	hmmbuild  --amino -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.20	0.72	-4.10	10	168	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	136	11	1	79	0	107.60	55	72.60	CHANGED	+cshuupL+DGt+lATGRIhCREsHTGFHlWhNuRQssG+PG+YIlQGp+DopHcLRVRluGpGWpssst-GtpGllppGpE-QshFDVhsDGNQplsPsEYllSVSGpCl	...sh..FRAGHVPDGMVLAQGaVTYHGSHSGFRVWSDEQKAGNTPsVLLLSGQQDPRHHIQVRLEGEGWQPDsVsG.RGAILRTAADNASFSVVVDGNQEVPADTWTLDFKA...CAL.	0	0	0	1
+5604	PF05776	Papilloma_E5A		Papillomavirus E5A protein	Moxon SJ	anon	Pfam-B_7244 (release 8.0)	Family	Human papillomaviruses (HPVs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. The kinetics of E5a protein expression during the complete viral life cycle has been studied and the highest level was found to be coincidental with the onset of virion morphogenesis [1]. 	25.00	25.00	130.60	130.50	22.80	20.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.22	0.72	-3.83	5	25	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	9	0	0	24	0	91.00	80	99.74	CHANGED	M-VVPVDlTssTTSsSLLPLVIALTVCllSIILIIhISEFlVYTSVLVLTLLLYLLLWLLLTTPLQFYLLTLSLCFLPAFslHQYILQTQQ	MEVVPVQIAAGTTSTLILPVlIAFsVCFVSIILIlaISDFlVYTSVLVLTLLLYLLLWLLLTTPLQFFLLTLhVCYhPAhYIHpYIVpTQQ.	0	0	0	0
+5605	PF05777	Acp26Ab		Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)	Moxon SJ	anon	Pfam-B_7275 (release 8.0)	Family	This family consists of accessory gland-specific 26Ab peptides or male accessory gland secretory protein 355B from different Drosophila species. Drosophila males, like males of most other insects, transfer a group of specific proteins (Acp26Ab and Acp26Aa in Drosophila) to the females during mating. These proteins are produced primarily in the accessory gland and are likely to influence the female's reproduction [1]. 	25.00	25.00	31.40	30.60	22.10	18.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.05	0.72	-3.54	4	17	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	8	0	2	28	0	88.50	77	86.89	CHANGED	MNYFAVLCIFSCICLWQFSDAAPFISVQSSSQSRSQKVMNGMLRTLYDYSVQDSVNDATGHLIHTHKADFNSDVMSP-EIEpVRQQLNMA	..........MNYFAVLCIFSCICLWQFSDAAPFISVQSSSQSRSQKVMNGMLRTLYDYSVQDoVNDATGHLI+THKSDFNSDVMSPEEIE+VRQQLsMA....	0	1	1	1
+5606	PF05778	Apo-CIII		Apolipoprotein CIII (Apo-CIII)	Moxon SJ	anon	Pfam-B_7283 (release 8.0)	Family	This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesised in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma [1].	27.10	27.10	27.20	29.20	27.00	27.00	hmmbuild  --amino -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.30	0.72	-4.59	6	42	2009-09-11 01:40:59	2003-04-07 12:59:11	7	2	27	1	16	35	0	65.00	61	62.42	CHANGED	EsE-uSLLuhMQGYMcpATKTApDALoSVQESQVAQpARGWMT-SFSSLKDYWSoFKGKFTsFWDSsPcs	..........EuEDsSLLuhMQG....YMp+ATKTApDALo.SVQESQVAQQA.....R..sWhTDuFSSLKDYWSoh+sKaSt..FWD.sPE.s.......	0	1	1	1
+5609	PF05781	MRVI1		MRVI1 protein	Moxon SJ	anon	Pfam-B_7407 (release 8.0)	Family	This family consists of mammalian MRVI1 proteins which are related to the lymphoid-restricted membrane protein (JAW1) and the IP3 receptor associated cGMP kinase substrates A and B (IRAGA and IRAGB). The function of MRVI1 is unknown although mutations in the Mrvi1 gene induces myeloid leukaemia by altering the expression of a gene important for myeloid cell growth and/or differentiation so it has been speculated that Mrvi1 is a tumour suppressor gene [1]. IRAG is very similar in sequence to MRVI1 and is an essential NO/cGKI-dependent regulator of IP3-induced calcium release. Activation of cGKI decreases IP3-stimulated elevations in intracellular calcium, induces smooth muscle relaxation and contributes to the antiproliferative and pro-apoptotic effects of NO/cGMP [2]. Jaw1 is a member of a class of proteins with COOH-terminal hydrophobic membrane anchors and is structurally similar to proteins involved in vesicle targeting and fusion. This suggests that the function and/or the structure of the ER in lymphocytes may be modified by lymphoid-restricted resident ER proteins [3].	20.10	20.10	20.40	20.80	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	538	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.63	0.70	-6.11	3	180	2009-09-11 20:56:11	2003-04-07 12:59:11	7	5	50	0	88	165	0	389.00	34	73.00	CHANGED	psEPcDGALDVsRsppCPuPTusPlPGssLpGCsRMN-DsSp-ENGVG+ssuESluQpREhhspsSS.PL.RtTSSo-GTlTSS-sGp-ILsMASsDLDcKsLCcKEE-sRAASPslc...........tQGTSLAc-sIuhpsSsuVuKslspLEAuEE.E.......ToEpccKESAuG-oVlSslPcsoVKpVNl+QSENTSA...NEKEVEAEFLRLSLGFKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKLLESLTPLCE-DNQAQEIlKKLEKSIslLSQCAARVASRAEMLGAINQESRVSKAVEVMIQHVENLKRMYAKEHAELEELKQlLLQN-.SRSssPsEDDsspptRSpSLSL.SKPSSLRRVTIASLPR..........................NlGNsGhVSGMENNDRFSRRSSSWRILGoKQSEHRPSLhRFISTYSWADAEEE..........Ks-lKs+DssEPpGEEsVERTRKPSLSE++usTpcWD+uolsSolASWVTaLQuSaRKAN...+ALWLouAhIlLlAALMSFLTGQLFQouVEAAPTQpGDSWsS.LEHILWPFTRLpH-GPPPV	....................................................................................................................................................................................................................................................................................................................s.t.....t...h..t....t............................t.tthh..sps.hshth.ph.ptttE.c..........................s.t.ttc.....ttt.s........u.s..hs...s.s.l+..lphppu.ssSA......sEKEVEs.FlpLSLuF+sD.aTLEpRlp.tERpRsLsEENhcKEl.....p......Nhht.lp...........u.................ssL..cc..sptpEhhpKL.csIshLpphssRluSRAEhlGAlpQEpR.hS.KAsEVMhQaVENLKRh.YtK-HAEL.EhKp..lh.QNp....Ru.h....s.s.........-D....tssp...ph..+p.Shs...uKs...shRRVolAslP+............................................shtss...............s.s........s...h.s..t+sss.....t.s....s..........s.......c.hp...hsc.p--...........p...t......................................t...............p...h...hh...h...h..phs.......phlhh.h.hhh...llhshlhuhh.t...h....p.s....tts.....................................................................................................................................................	0	15	22	50
+5610	PF05782	ECM1		Extracellular matrix protein 1 (ECM1)	Moxon SJ	anon	Pfam-B_7421 (release 8.0)	Family	This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis [1,2]. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalised thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness [3].	25.00	25.00	27.80	27.80	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	544	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.10	0.70	-5.79	3	78	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	33	0	30	80	0	339.00	43	97.22	CHANGED	MGTsSRAALVLACLAVASAASEGGFKASGQRELsPE.LhpHLQEVGYAAPPSPPLSRuLPhDHPcTSQHuPP.FEGQSEVQPPPS.EshPl.pEch.sh..Ps.ccsGPslPQEAIPLQKELPPPQVPIE...............QKEsKPAPhuDQSPPEPESWNPAQHCQQGRsRGGWGHRLDGFPPGRPSPDNLcQICLPsRQHVVYGPWNLPQTGYSHLSRQGETLNlLETGYSRCCRCRS+TNRLDCAKLVWE-uhoRFCEAEFSVKTpPHhCCp+QGEARhSCFQEEAPpPHYQLRACPSHQPsIS.G.ELPFPPGlPTlDNIKNICHL+RFRSVPRNLPATDslQRpL.ALhpLEtEFQRCCRQGNNHTCTWKAWEDTLDGYCDREhAIKTHHHSCC+YPPSPsRDECFARRAPYPNYDRDILTLDLSRVTPNLMGHLCGNpRVLSKHKQIPGLIQNMTARCCDLPFPEQACCAEEEKLAFI--LCGPRRNhWRDPALCCcLSPGDEQINCFNTNYLRNVALVoGDTcNAKG.GEQGPTpGTNuSPTSEPKEE	...........................................................................Mtsh.hAAhlLhhlAlsusAptGu..s.tphp.hP................................................................t....................t................................................tt.ls.Qpc...........t............................................................hp..t......u..l..sFPPGRPSs-NLppIClspRp+llYGPasLP.poGaSHLsRQGcslNhLEhGYopCC+...sp...s...p...spp.....LpCsc.sWccshppFCctEaSsKTpsa.CCp..pGpt..RhtCFpptuPpspY................................................................................................................................................................................................................................................................................................................	0	1	5	11
+5611	PF05783	DLIC		Dynein light intermediate chain (DLIC)	Moxon SJ	anon	Pfam-B_7447 (release 8.0)	Family	This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organisation, and function of centrosomes and mitotic spindles when bound to pericentrin [1,2]. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organisation by binding cytoplasmic dynein 2 to its Golgi-associated cargo [3]. 	19.70	11.00	19.90	11.00	19.60	10.90	hmmbuild  -o /dev/null HMM SEED	472	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.64	0.70	-5.82	8	500	2012-10-05 12:31:09	2003-04-07 12:59:11	6	6	234	0	324	498	9	276.10	25	71.25	CHANGED	-EGQNLWSuILSEVSTcucSKLPSGKsVLVhGEcGSGKTTLluKLQGsEcsKKGRGLEYLYlsV+DEDRDDhTRCsVWILDGDLYHKGLLKFAlstpslc-TLllhVlDMSRPWohM-SLpKWsSVLR-HIDKL+IPPEEh+-hEQ+ls+sFQ-YlEPt-sh.sGSPQRRsspssu.D--SllLPLu-slLTpNLGlPllVVCTKCDAhosLEKEHDY+DEHFDFIQuHIRRFCLQYGAuLIYTSVKE-....KNLDLLYKY..lVHKlYGFsFssPAlVVEKDAVFIPAGWDN-KKI.uILHENFpslKsEDsaEDhIsKPPVRKhVH-KEl..tAEDEQVFLhKQQSlLuKQPsTss.RssESPsRussGSPRsssRouPssVuSsuPhso.sKKsDPNlKsuusS.EGVLANFFNSLLoKKoGSPGusus......GGsssstsosstsos+KoGpKslLTDVQsELDRhSRKs-phls.ssu.Tps	........................................................................................................................................h..h......G.t...sp.p.hh.......h....................................t...................................................................u.....LtYha.............h.p...h....h....c............t......t...p.................p.................s....s.....h......h....pha..L.s....s.s.....h....ts....Ll.p.....l.s...psl.....phhlhhhhDhop...P...W.hhcpL.pp.a.h.p.h....l....p.p.hl.......p..h.....p............pt...........h...p.....t.h.p.ph.p.hpp...................................................................................................................................t.......................s....h.....hhhhh..................tsc.h..............................h.tp.p......t.....hp....p..hDhl...hhRphhhth.......suu...Lha...h.s.........................ph....hh..p...............hhp.....h..............t.......................hhcpptlhlP.shDs.thI..thh...pth...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................pt...........................................................................................................	0	125	167	249
+5612	PF05784	Herpes_UL82_83		Betaherpesvirus UL82/83 protein N terminus	Moxon SJ	anon	Pfam-B_7466 (release 8.0)	Family	This family represents the N terminal region of the Betaherpesvirus UL82 and UL83 proteins. As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditions to suit their own needs. Human cytomegalovirus induces quiescent cells to enter the cell cycle and then arrests them in late G(1), before they enter the S phase, a cell cycle compartment that is presumably favourable for viral replication. The protein product of the human cytomegalovirus UL82 gene, pp71, can accelerate the movement of cells through the G(1) phase of the cell cycle. This activity would help infected cells reach the late G(1) arrest point sooner and thus may stimulate the infectious cycle. pp71 also induces DNA synthesis in quiescent cells, but a pp71 mutant protein that is unable to induce quiescent cells to enter the cell cycle still retains the ability to accelerate the G(1) phase. Thus, the mechanism through which pp71 accelerates G(1) cell cycle progression appears to be distinct from the one that it employs to induce quiescent cells to exit G(0) and subsequently enter the S phase [1]. 	20.70	20.70	20.80	23.10	19.10	20.40	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.80	0.70	-5.70	18	118	2012-10-03 01:18:03	2003-04-07 12:59:11	6	1	26	1	0	132	0	340.30	31	63.36	CHANGED	shs.luspllphlh.pscsslcPcEs+llcTGlsVpVsp.sollhlsp.sspspssht.pp...........LplKapshcsp.-hcs.lslsVpN.os+s...lssus..pPl.ulhVFALPLstVslssLplaps.............htppth.pssucsslpphstphWplRlsloplpWscppsphhtsshhasosFhhpspshPLptl.sssc.lsCSptssplp+sphhscs....hlhlaL......phpppsPPsplFlplul.hspp......................sclshp+NPcPaLp.pscNGFslhsP+slplp.sscpsplhlsssFcSsp.asulFhPpsIPGlSlsssshhsppslhlclpuhpc.slplcthpsLGtl+FFs+shlhh	.........................................s.hu.luspllptlhspssssltPcET+lLpTG.lclpVsp.PSllhlsQhsscussspp.ppp..........Lplpasshs....sp.-hc..s...lsVsVpNsosRs...lsPup...csh.ulhVaALPLchVslsslsla+h............tscccp..+phssscAslctssp.....phWpsRlTVoslsWs+ppsphp......t......ss......h.hasouFlhsspslsLp..........p......l.s........sAcpLsCS.tsTpls+hpllscp....hlplal..........cp.hspss..P..sspLFhHlsl.pspc.......................tcl.shpRNPpP.ah..+s.a.c....cN.GFp..VlsP+shtl+.sGchsplhlcsuFpS..cp..ahuLhhPcsI.P.GLSIpsshlhsspplhlclpuhtc.slclcthpslGtlaFFcpchlh.t...	0	0	0	0
+5613	PF05785	CNF1		Rho-activating domain of cytotoxic necrotizing factor	Moxon SJ	anon	Pfam-B_7489 (release 8.0)	Domain	This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells [1]. Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain [2].	25.00	25.00	131.30	130.50	18.00	15.80	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.69	0.70	-5.50	10	55	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	44	2	6	44	0	278.90	37	34.56	CHANGED	slpphushs...hppLspGsIslLKG+Glluu+cspp..............Plshhlshl+aDsss.h.t.........pupDpshaG.lhuhsGssltsopsu.....PuoslGpaasptsLosNlsll+VsNGsRGssGl+IsLs-lpcupPlllTuGsLSGCTolsApKcshlYtaHsGps.sstusWhTup-GVpplhcstpsLupsssPslssspNNs.LV-aLucsFDpulIsYsG+sccssut.t........cNVslFDYsts.hscpstsRlGsuhsLlo.ssssslsVpoLuEDhslN..ususchsVL.ss.....h.Ksh	..............phupps...hptLs+GsIslLKGRGsluup+pps..............sl.FhIphsRaDp................puhDphhas.hhuhsGhshhss.su.....suohhupaacchsLospssII+VsNusRGssGIKIsLc-VpcupPlIlTuGsLSGCTTlsApKcuYlYthHTGpo.pshusa.TussGVpphhcshchLstps..hspltshhssD.LVsYhScsF-culIsYsuppcpssupht........cNVslFsY..h.hpshs.hthGsuhTlls.pssGslslpoLuEshulN..usssphslLps................	0	1	1	3
+5614	PF05786	Cnd2	Barren;	Condensin complex subunit 2	Moxon SJ	anon	Pfam-B_7477 (release 8.0)	Family	This family consists of several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons.  Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localises to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase [1]. This family forms one of the three non-structural maintenance of chromosomes (SMC) subunits of the mitotic condensation complex along with Cnd1 and Cnd3 [4].	21.70	21.70	22.10	21.70	20.80	21.60	hmmbuild  -o /dev/null HMM SEED	725	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-13.54	0.70	-6.02	15	462	2009-12-23 17:17:02	2003-04-07 12:59:11	9	6	285	0	333	491	3	510.80	21	88.67	CHANGED	psp.t+psstusptchsoshp........lshNDDptE+ppR...........................RRhosh-ttsopsuuss.u...........st.pshhshhps.pIhpsacpClKLuo-NKIsscNuWshsLIDahsDl...ppK-u-hsNFQhAusTLDAusKIYusRVDSVas-shKlLuGL......u..p..pcspcpss-G..ss-sc-s-utthtpcsspcKs.++K..RsstuTls.shsslslp+h-hchsVDPLFpKsuAsF..DEsuupGLhLNpL.ulDupuRl.....lFDSs-sst.............................ppupsschssssplDhosLt..................................hs.Lspl-cpsICPSLssap..hs-sst..s..Fsctsp-hcs-sht..ttt...............shs-ctp.tshuFDlsu-sts.....................stusuG-ttphcstpEsh.cspcspccsspht-s.tssD....hshsLst........s.hSYFs.sphppsWAGP-HWKaR+h+.................pscsssposut+pKKc.KcshclDFsssl-....-hhFp.ssusoslohsphpppscspsh.LPsDhHasscpLl+LaLKPps+hsp............hs.cpcssspsss-hD-h.asNpp.....................tsDssshhPsh.utssD.-DDstsFsDssshh..ps.st..t.sutttstt.t.shhshhtsplhusP....................++Vphl.VsYA+sAK+lDh++LKpshWphlscph.sssp.ts..................................ctp-psppssptpFoplhpsLtshhP.sphtcslSsShuFlCLLHLANE+sLpLpss-s........L-DlhIpps	..........................................................................................................................................t......................................................................................................................................................................................................t.hpph.hch..scN.KIsttNsa....s....ht.LIDhhtp..h........................c........p....t....p....hN............F...ph.....A.........usoL-u....ssKIYs.RVDulhs-sh+llusL................................s..........t..t.............................t....t..t...t.................t.........................................t..t.........t.............t.........................t.........p...t.................t..T.l..phttlp..pph..-.........t.....h....DPhFtph..........sth..D.susttl.hhs.L...............t.pl.......hhsst........................................................................................................................h.............................................................t..l.....htth............................................................................................................................................................................................h.......................................................................................................................................................................................................................................Wt.u.......t.....aWpht..................................................................................p..p.t..............h.pa.........t......................h...h.t....................................................................................h..............................................................................hP......c.hth..t.h.ph.......hst..h.........................................................................t...........tt............................................................................................................................t......................................................................................................................h....s...............................................h..t.....l.aschu..KphDh+tLKpthap.ht.........................................................................................................................h.hpplhpt.l.....p..hs..............hpp.......lS..hhFhslLHLANEptL.l.....t...........tp...............................................................................................................................................................................................................................................	0	132	200	290
+5615	PF05787	DUF839		Bacterial protein of unknown function (DUF839)	Moxon SJ	anon	Pfam-B_7480 (release 8.0)	Domain	This family consists of several bacterial proteins of unknown function that contain a predicted beta-propeller repeats.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	524	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.90	0.70	-5.57	15	1732	2012-10-05 17:30:42	2003-04-07 12:59:11	8	25	946	0	506	2061	586	374.30	27	79.74	CHANGED	hsauslssssD.....chlsVPcGYchcllspWGD.lhss.Pth......s..tptt.hGhNpDGMuhFsl.......................sps.....+s.LLlsNHEYsssslhh.......................tstshstcpVptthAAtGsTllpl.c...ttta.hs.suthNRR...........................lptso.h.l..sGPsuGppll+ot...........ts.spGsplhGThsNCAGGsTPWGTaLTCEENhss...hFus....................pphG.....sth...........pFs...............sccaGaVVElDPhcP..posPhK+TALGRFpHEusslh..csuR.sVlYhGDD...cpssahY+FVsscphpsts.....ttspsLh-sGsLpVA+hsss....................GsscWlsLs.s............................................................ps....st..htsts-lhlpsRhAA.ctlGAT+McRPEslt.ps..h.....cVYhshTNss.tp......................h.....ssuNsRscNtaGpIh+ah.sss.....phsstp.pW-LalhuGsstssp.........s.stsshhssPDNlshDstGcLWlsTDGssst.t.......................huts.G......h.sts..pup.chhh.ssPtsuEhsGssFoPDucThFVslQHPG	..................................................................................................................................................h...............................................................................................................................................................................................................................................................................................................................................................................................................hhG.hh.sCus.u.o.PWsThlosEENhss............hF..s.st..tt............................t.p+.h...G.h....t...h....................................................................ca.shs..................spspcaG..allE..l..D....P..........hss......p....us.......s........h.......K+TA..LGRFpHEsst.h.h.............t.....s....sp......hlsYh.GDD..........pp.p.alYKFVuptthp.t.................tts.ph......L......s......pGsLYV..A+.a.s.ss........................................................GsspWl.Ls..s..............................................................................................hp...................tss.....h..s..tspl...h..l..s.RhAA.shhGA.....T........hcRsE.ht.p..st..................phahshop.t..........................................................................................Gt.l.h..t..h............t...................................t....h...............h......h.........s.................................................hssPDsh...h.h....s...............h.......l.h.l..pD.t............................................................................................................................................................................................................................................................	0	144	336	453
+5616	PF05788	Orbi_VP1	Orbivirus_VP1; 	Orbivirus RNA-dependent RNA polymerase (VP1)	Moxon SJ	anon	Pfam-B_7493 (release 8.0)	Family	This family consists of the RNA-dependent RNA polymerase protein VP1 from the Orbiviruses. VP1 may have both enzymatic and structural roles in the virus life cycle [1].	20.00	20.00	20.30	32.30	17.50	19.90	hmmbuild  -o /dev/null HMM SEED	1301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.07	0.70	-14.19	0.70	-7.37	6	192	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	69	0	1	156	0	507.60	51	99.54	CHANGED	VQsApLl+RulpRlhpGI+hctscutshYYKaS-phR+hRcK+GspYK+-s-.hE+phchptcpLYGLPVl+EuSWc-lhs...hpphppssLclalcSlLchp-L-PEEEFLRNY+Vp......cphpshp-FVEpRA+sEhQlaGDlslKtWsuhLhElupphKHpPLGLpVMucFVpRFGpPFHQNsRDLSQlcDashsYooPLLFEMCssESllEFNhhhRM+EEsIppLEFGsp+lsPhcLlREhFllCLPHPKKINNhLRAPYSWFVKhWGVGucclhVLpStGGDDRNSK-VhYssF++hpNhYu.slh+SpFYpco+cpNhpKlcEtlpYSQ-LGsHshshPlF.+ML+sVYpTsFsPpchSHlILASahLSIQTITGYGRAWVKNsuoDhEKQhKPssuNhlsRVsDhT+N.FIQAYpEAcc+GE-IVpPEDMYTShLRLA+NTSSGFSTplpVhK+YGPshc.+cpchI+IsSRIKALVIFpcGHcIFssEpLcKKYNTVE.YQoKGSRDVPIKATRhIYSINLSVLlPQLIVTLPLNEYFu+lGGSTpP-s++lGGKIIVGDLEATGSRVhDAADTFRNSuD.sIhTIAIDYSEYDTHLT.aNFRpGMlpGIRcAMp+YpcLRYEGaTL-ElIEaGYGEGRVssTLWNGKR+V.hKhsh-cYhpLsEp-Rl...cGsFK.sPhGVhPl+slclsp+lplc.Dsc-hlLVuPsDGSDLAh..lsTHLSG.ENoTLlhNShHNLAIGTlIQEElp+cssslloFhSEQYVGDDTLFYTpLpspcscthDpllcTIF-TIt+sGHEASsSKThhsPFSVEKTQTHAKQGlYIPQDRMMlISSERRKDIEDVpGYlRSQVQThlTKlSRGFSH-LAplILMhKToFlGaRKhKRTIhEsGtYRDR+FDSscEDGFTLhhlRsPLsLYlPV-WNGaGAHPuALNlVMTEEhFlDSlhhuphc-hhtPlh+Ihsss.PsWNETpuDKRtlsTcTKMSFFSKMARPsVpoVLsssElhctVcpLPLG-FSPspIS+TMMHSALLKEspARoLLoPsYEl-YQKplNsWlp.psshphpup-hpISTsYsKlFcVhFEsshtpuhhh..FPD.NLSPp.Fa.QKhhlGsRhSsRsRhSY.VDRIDSILRuDVVMRG.......FITuNpIlslLEclGhsHSAuDLshlFolMNl-s+VAE+LupYIsp-KIRFDAhKL.K+GICGDEFSMSLDVCTQsMlDcal+aP+pLTKTEhDAVsLYsSQllMLRAApGlshp+hclsVosEcK++aKVRtsRFpoHlPKh+hlK+L.hshcRLSuRhlpNQFV	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LaYscLpopctphhsphhpsIFsTVtKCGHEASsSKThhsPaSV................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	1
+5617	PF05789	Baculo_VP1054		Baculovirus VP1054 protein	Moxon SJ	anon	Pfam-B_7511 (release 8.0)	Family	This family consists of several VP1054 proteins from the Baculoviruses. VP1054 is a virus structural protein required for nucleocapsid assembly [1]. 	20.40	20.40	49.70	49.00	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.26	29	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	57	0	0	56	0	332.90	39	96.61	CHANGED	phspsso.+.ss.a+Pl+h.s+.pQC.hHPpRANC+lh+hhs..........c.........................pshh.HhThl.sshahshsscPYYphLlpspt...shtt.httahNAsphhshlplc.......sssEcahuI-EAGEpNhshl+hVlKslhchlss.s...............schYl.lhhcchalDhlYSph+sl.lLPQcMYslappp...................ptP..hsphhphholPps-c.........uhpSQ.IY+oFLlYNTVLTMhLKQpNPFN-..psKsIShIlRsLGpCP.....sN+sRlKsC-LpaGGs.sP..GHlMCPP+-MVK+Ia+YAKWshsPNNY+RYacLIsc.sshps......................t..shhLhDWhsFlssFpsYFh	....................hspCsS.K.sP.a+Pl+h.s+.sQChlHPp.RANC+lh+phs..........s..ps....................pshh.HhThl.sshahshsscPYYptLLpssp.....................phtt..RttalNAs.phhshVplc.......sssEcFhuIDEAGE+Nhssl+hVl+slhchhss.s...............schal.LhlDchalDllYStaRsl.lLPQchhslhpcp......................ptP..hsphhphhsVPso--.........uhpSQhIY+oFLlYNTVLTMlLKQsNPFNs..psKsISlIlRsLG+CP.....sNK-RlKCC-LpY...GGs.sP..GHlMCPPREMVK+IFHYAKWscsPNNY+RYa-LIsc.ss.ps.th..........s.tt..t.ts..sLhLhDW.NFls-FpsYFh............................................	0	0	0	0
+5618	PF05790	C2-set	CD2;	Immunoglobulin C2-set domain	Bateman A, Finn RD, Moxon SJ	anon	Bateman A	Domain	\N	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.70	0.72	-4.01	27	320	2012-10-03 02:52:13	2003-04-07 12:59:11	10	44	68	56	79	345	1	77.80	26	27.95	CHANGED	losssss.ssLss-sLphs....s.hhp.plphcp.ppKs.cspphhhshp...p-sG.sapChsp......sts.pphpsshpl.shs	.....hosssts.plLss-sLsho..h.t..s....s.hh.p.plp..hcs....stKs....h.....cspphhhshp..hp-sG.sapCpsp.........sps.pphpsphpl.s.........	0	5	5	12
+5619	PF05791	Bacillus_HBL		Bacillus haemolytic enterotoxin (HBL)	Moxon SJ	anon	Pfam-B_7539 (release 8.0)	Family	This family consists of several Bacillus haemolytic enterotoxins (HblC, HblD, HblA, NheA, and NheB) which can cause food poisoning in humans [1].	25.00	25.00	25.00	25.80	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.05	0.71	-4.92	13	739	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	144	1	36	537	0	178.80	32	47.98	CHANGED	pNhSLu..spshpculcptGSpshlhssYuhhIlpQsslslsslo..sh.sph.tslhpcQcsA+sNAppWlDphKPpllpssQsIlsYsTpFpsYYssLlpsl.....-ppD+sshpsslscLpspIppNQcsscpllp-LpsF+splscDopsFpscs......splpsILpuss.AsIstLcpcIpshpssIpps.s	.......................................phths..stthppshpphGuphhhhphYuhhllppPslshpslo..p..sth.tslhpcQc.A+tsAppWlsph.KPQLlc.TspsIlsYs.....T.....p.....F.....psYYsoLlpsl...............sppDpssLpc....uls.cL....p....s....p....IppNQppsppll....p-Lpca+s.plspDspsFpscs......splpuILtups.usIstLppcIpphpssIptp..p........	0	14	21	23
+5620	PF05792	Candida_ALS		Candida agglutinin-like (ALS)	Moxon SJ	anon	Pfam-B_7578 (release 8.0)	Repeat	This family consists of several agglutinin-like proteins from different Candida species. ALS genes of Candida albicans encode a family of cell-surface glycoproteins with a three-domain structure. Each Als protein has a relatively conserved N-terminal domain, a central domain consisting of a tandemly repeated motif of variable number, and a serine-threonine-rich C-terminal domain that is relatively variable across the family. The ALS family exhibits several types of variability that indicate the importance of considering strain and allelic differences when studying ALS genes and their encoded proteins [1]. Fungal adhesins, which include sexual agglutinins, virulence factors, and flocculins, are surface proteins that mediate cell-cell and cell-environment interactions. It is possible that both the serine/threonine-rich domain and the cysteine residues in the C-terminal and DIPSY Pfam:PF11763 participate in anchoring the terminal domains inside the wall, so that only the inner part of Map4p, including the repeat region, is sticking out as a fold-back loop then able to act in adhesing [3].	25.00	11.00	25.00	11.00	24.50	10.90	hmmbuild  --amino -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.61	0.72	-3.82	189	1619	2010-01-07 11:49:09	2003-04-07 12:59:11	8	56	22	0	1025	1644	0	32.10	46	32.08	CHANGED	sThT.phWoGohsoTsTh...oss.....PGtTsTVl..Vp.lP	.................sTsT..pa..Wo....t.S.h.sTToTl...Tss.......PG.u.TcTVl...lc..P.....	0	289	393	1025
+5621	PF05793	TFIIF_alpha	TFIIF-alpha; 	Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)	Moxon SJ	anon	Pfam-B_7586 (release 8.0)	Family	Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	528	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-13.00	0.70	-6.13	8	332	2009-01-15 18:05:59	2003-04-07 12:59:11	7	11	190	9	210	310	2	299.90	25	69.07	CHANGED	uut...suos.spslpEYsVRVspsscK.+YalMR.......FNupcsV-hspWs...tsphER-.s.+.hht.pphh.-hGtGSEas+stREEuRRK+aGh..+ca+.-sQPWlLchst.c-G..+pF+Gl+EGGsoEpAoYYlFs+ss-uu.FcAaPlspWYNFsPlApYKsLThEEAEEcappR+KThNtFslhhhKthpss.s.hu-csE-c-t....pKuGsG+u+.....L+I+DhpsD--.-ussS-pu-ED--Etts.+Kc......s+hAKN+Kp..sDpK+p+RsuD-...-sh-.DS-DGD-EG+EhDYhSDsuusus-.-..........................E+E-hhusEcssKt-.cQs-cs-EcE-EcsEc-ut.SKctKKsKK.psKpsch..c-Sp-s-sSD-SDsDs-susshhpspKpKc.t+-EslsSusSusssStPupPossstsopuKRKhs...........spsSpsPsSsssKKlKhEssPpSs.tKuhPso.St................ssossuu-hslTEEsVRRYLh.RKPhTTpELLsKF+sKpssLSoEcsV.....sshApILK.+IsPlpKshpsphahsL+p	.........................................................t......................................................................................................................................................................................c.t..PWhlc......c.s...........tta.G..hcu.u.s...........ssahl.hh.......st.....t...hphhPhppa..YpFp.htpapsLohEEAEptht..++pp....s.t..h.hh..+th..t..tt........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	63	99	165
+5622	PF05794	Tcp11		T-complex protein 11	Moxon SJ	anon	Pfam-B_7604 (release 8.0)	Family	This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility [1,2,3]. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants [4].	20.40	20.40	21.80	20.70	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.33	0.70	-5.77	30	596	2009-01-15 18:05:59	2003-04-07 12:59:11	8	8	254	0	373	557	18	379.30	23	61.79	CHANGED	pLtH-Ishs.shph+...Ps.su.cu+hKcphpcsaW-tlppplstt....................sPpasphlpLhppl+-hLhSLL...ss+h+spIsElLDh.-LlpQQhc.+GulD...hsphupalhslhtphCAPhRD-tlpchpppl...................pclVptLRtIFplL-hMKlDhANapIpshRPhLhcso.V-YE+ctFpphl...p+sssslssopcWhpcstscthpphpptst.............................................t.ss.ssh.llhpuhlcL..lhptptspsFPETLhhDpsRLtpL+splppLsslusslllhpshlssthpss.........sphhs+lppplhsLlpt......sss+hscslpsIu.plspp............htpshsppstsslssshpsslputLtphhpss.ssVhplhcp+lhphlhstlh...............................ssspcshsssssshs.ht.............................ElpplupphspLssashpVaGs.aYhch..........lpph	............................................lhH-l.hs.phphc......s...su.............psch+chht.....psaWctlppplptt..............................................................sph.s..phltL...h..p..pl+-....hLh.s.hl...............................sch.+...sp.....IpEsLDh.-ll.pQphc...pG.shc........................httlspalhsh...htp.hCAPhRDpt.lpphtp.h.........................................t.phVp..hl....+tlh....plLchMK....h...........DhsNatl.....p.hp.PhL..hppu...lpYEpptFpchl........................ppts.......sL...shoppWhppshpph.ht.ph..pts..............................................................................................s..sh..hlh..puhlpL............h..s......t......ct..h.P.E.TlhhDptRltplptphpplh.hhusshLlhpshht.t..h..s..............................t.hp..plt.phhhs....llpt.......................p....p.pp......sh.sls..ph..t.......................................................tsh..t.t..t....s...sh....s..p.p......t....h...........s.l.....t.p...hp...p......s.slhplhpp+lhhhl.shlh.................................................................................t.ttt.....h.shsh.......................................................................clttlst.thhp.lhthp.tVaus..hY.th....h....................................................................................................................................	1	87	166	269
+5623	PF05795	Plasmodium_Vir		Plasmodium vivax Vir protein	Moxon SJ	anon	Pfam-B_7631 (release 8.0)	Family	This family consists of several Vir proteins specific to Plasmodium vivax. The vir genes are present at about 600-1,000 copies per haploid genome and encode proteins that are immunovariant in natural infections, indicating that they may have a functional role in establishing chronic infection through antigenic variation [1]. 	25.50	25.50	25.80	25.70	25.20	25.40	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.73	0.70	-5.25	125	471	2012-10-01 19:45:41	2003-04-07 12:59:11	6	4	6	0	383	877	0	296.30	13	89.84	CHANGED	Lsutch.........Ycchsp........p.tp.........p.hsshCp.phpph.........pplp....clCpKlhctLc..hlsptp.pppct............ChalpYWlY-pltphhp......tp..p.h..hhsclhplhpph.ppth...........p.pt..............................................Cp..hphh....hcp..hcccKpLaDYacsacsIcpphpspspp..C..pp.Yh....................pYlpphppLYcc..a....ppp..Cspttp.................shCscahcp..ppcY.sPpslLspL.pCt.t.......................................tpttt...t...............tttht...t..t..........t.t...t..............................................................................................tt.....tth.....ss.hhshh........hh.hh.hhh.p.............................................htp.hppthtppppthpp.httphth.h.t.tstt...t........................pph.ls....Ypss	.......................................................................................................................................................................h....t......h.................th..........phh.p..phhp.hp.........htp.......ttp....................C..ahpYWl..hsplhphht.p.................hhpphhp..hhpph.p..pt.................p..pp..............................................C.p....h.ph........hsp...hcchKtLa-Yh.p.s.ap.pl...p..p.t.....h....p..stp.......pt....C....pp.ah..................................pYlpthtp..h.Ypp....h..........ppp.....Cspttp.................thC.pa...h.ph................pph..ps...p...plltpl....pstt..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hh....h.h.p.............................................................................................................................................................................................................................................................................................................................................................	0	0	1	300
+5624	PF05796	Chordopox_G2		Chordopoxvirus protein G2	Moxon SJ	anon	Pfam-B_7672 (release 8.0)	Family	This family consists of several Chordopoxvirus isatin-beta-thiosemicarbazone dependent protein (protein G2) sequences. Inactivation of the gene coding for this protein renders the virus dependent upon isatin-beta-thiosemicarbazone (IBT) for growth [1].	25.00	25.00	126.20	126.00	18.50	18.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.37	0.70	-5.21	12	66	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	41	0	0	48	0	213.00	60	96.15	CHANGED	MsFR-LILFaLuKaLlTcsctuh+phlSLCRuFslchpcllscFhsp+hh+plopslppss.lLsElslsFPssll+-LlpLRLp+FsKslKtSh+LssshpGIsll.cspplhlhpsNDpLlsaLh+cYsPplYpYs.........stPsshsGu..............+lllCGhsploFasYhho.+IsoNpclcVlVT-pCIppLLp.tNtpLLcplF..c+usssls+sL+cIF....YSl	MPFRDLILFNLSKFLLTEDEESLElVSSLCRGFEISY-DLIoYFPDRKYHKaIsKVF.EHsD.LoEELSMEFpDTTLRDLVYLRLYKYSKsIRPCYKLu-NhKGIVVI.KDRNIYIREANDDLIEYLLKEYTPQIYTYSs.........E+ssIsGS......................KLILCGFSpVTFMAYTTS.HITTNKKVDVlVoKKCIDcLlDPINYQILpNLF..DKGSGTINKILRKIFYSV...	0	0	0	0
+5625	PF05797	Rep_4	Yeast_TAF; 	Yeast trans-acting factor (REP1/REP2)	Moxon SJ	anon	Pfam-B_7680 (release 8.0)	Family	This family consists of the yeast trans-acting factor B and C (REP1 and 2) proteins. The yeast plasmid stability system consists of two plasmid-coded proteins, Rep1 and Rep2, and a cis-acting locus, STB. The Rep proteins show both self- and cross-interactions in vivo and in vitro, and bind to the STB DNA with assistance from host factor(s). Within the yeast nucleus, the Rep1 and Rep2 proteins tightly associate with STB-containing plasmids into well organised plasmid foci that form a cohesive unit in partitioning. It is generally accepted that the protein-protein and DNA-protein interactions engendered by the Rep-STB system are central to plasmid partitioning. Point mutations in Rep1 that knock out interaction with Rep2 or with STB simultaneously block the ability of these Rep1 variants to support plasmid stability [1].	25.00	25.00	28.40	27.90	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.07	0.70	-5.74	6	16	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	15	0	5	17	0	267.80	26	83.62	CHANGED	pss+Elhphlp-shhhhshhslYsPppshllTs+GohplP-sYpcYPhLAlaYVpYhlpK.Pasll.s-L..-WP-PYVVlNTIh+RLpsH+ah.uNp.tsshs-cl+phIusul-IPpsp..csEhLsp.tKs+phstph..phh-s.ss+pclpcFFscLp-hsthushasshoKlclhlSCpuhh.upu.clphhApslR+lWltEhlhshsspcpc..tshDp..ssh-Dsp.....sptppsuus.p.scAp...........................uaWchlcsLpcp.p.pspp.pphchlAshlhuppcthtshpppRcpsRshLYhpl+thL.pphphpha+Gspshps.plKlSL+hpcp	......................................cth..hh.pshh.h...hla..tpp.l.T.pGhh.lPcpYtpa.hLAhhaltahhpp.sh.hh.ppl..-WPcPhlVhNTlhcRh.pH..h..tph..sthhppl+thlu.slphs.pt.....hht..tp.h.h..th..phhcs..sppclptFFphLpshsthtp.a.s.oKhhlhhSspshh.tps.phphhtpslRp.hltEhl.phhppcpp...hh-p..sst-Dsp.....sptp.su.stpsspup...........................thhp.lssLpcp.pspspp.sphchluthlhup.pt.tphphpppph+shlYh.l+thl.tsphplchYRGsphpps.slKlSL+.pp.....................	0	1	3	4
+5626	PF05798	Phage_FRD3		Bacteriophage FRD3 protein	Moxon SJ	anon	Pfam-B_7781 (release 8.0)	Family	This family consists of bacteriophage FRD3 proteins.	25.00	25.00	142.30	142.10	21.50	19.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.38	0.72	-3.66	4	35	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	31	0	0	15	0	75.30	80	99.28	CHANGED	MAKVsIDlVDFEYhEElIRNRYPELSIsSlpDopFaolplslpGPLEcLppFMsNEYCDGMcsEDAcFYhGLIcp	MAKVDIDIVDFEYIEEIIRNRYPELSITSlpDop.FhShQIVIEGPLEDLTRFMANEYCDGMDSEDAEFYMGLIEQ	0	0	0	0
+5628	PF05800	GvpO		Gas vesicle synthesis protein GvpO	Moxon SJ	anon	Pfam-B_8221 (release 8.0)	Family	This family consists of archaeal GvpO proteins which are required for gas vesicle synthesis [1]. The family also contains two related sequences from Streptomyces coelicolor. 	21.00	21.00	21.00	21.60	19.00	20.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.01	0.72	-4.12	17	117	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	92	0	50	129	1	98.40	33	85.36	CHANGED	tppptt.ps.......sttssphhsht-shptAppshp-Lht+chEulsuspps-D.GWpl.VEVlEpptlPDTpDllupYElpLDssG-lhuYcRlcRYcRGchcp	...............................................tttt.................t..shhpshctAtpplscLhGcp...s-uVoulpps.......--...GWpltVEVlEh...p...RlP...c...Tssl.....LAp.....YEVpLDscGcLhuY+RlcRYpRGpsc.t...	0	17	39	48
+5629	PF05801	DUF840		Lagovirus protein of unknown function (DUF840)	Moxon SJ	anon	Pfam-B_8265 (release 8.0)	Family	This family consists of several Lagovirus sequences of unknown function, largely from rabbit hemorrhagic disease virus.	25.00	25.00	213.00	212.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.40	0.71	-3.95	2	29	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	9	0	0	26	0	113.10	93	97.04	CHANGED	MSEFlGLsLAGAusLSsALLRpQELtLQKQALEsGllLKAcQLupLGFNP.EVKsllV.GpuhspNhRLSNMHNDuSVVNuYsVhNPsSNGIRpKIKShNNSVKIYNTTGESss	MSEFIGLGLAGAGVLSNALLRRQELQLQKQALENGLVLKADQLGRLGFNPNEVKNVIV.GNuFSSNVRLSNMHNDASVVNAYNVYNPASNGIRKKIKSLNNSVKIYNTTGESSV	0	0	0	0
+5630	PF05802	EspB		Enterobacterial EspB protein	Moxon SJ	anon	Pfam-B_8424 (release 8.0)	Family	EspB is a type-III-secreted pore-forming protein of enteropathogenic Escherichia coli (EPEC) which is essential for EPEC pathogenesis [1]. EspB is also found in Citrobacter rodentium [2].	21.60	21.60	21.70	21.70	20.70	21.50	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.07	0.70	-5.48	3	178	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	139	0	5	79	2	257.00	53	97.58	CHANGED	MNTIDYNNQVhsVNSVSESTTGSuSuTAo.s.SIsSSLLTDGKVDISKLMLEIQKLLGKMVTlLQDYQQ+QLAQSYQIQQAVFESQNKAIEEKKAAATAALVGGAISSVLGILGSFAAINSATKGASDIAQKAoSASSKAlsAASEVATKALVKATESVADAAEEASSsMQQAMATATKAASRTSGVADDVAsSAQKASQlAE-AADAAQ....KASRlSRFhAAVDKITGSTAFVAVTSLAEGTKTLPTTISESVKSNHEINEQRAKSVENFQQGNLELYKQDVRRoQDDIASRLRDMToAARDLsDLQNRMGQSuRLAG	................................................................sNss.psTTsusu.s.ss...u.sSSLLTDG+VDls+LhLElQKLLtKMVslLQDYpQcQLuQSYpIQhAVFESQNKAI-E....K.KAA....ATA...ALlGG..hISSsL....GI.LGS.F.........A......Ah...N..s...AsKG..Au-lAp...p...su.S....sSSKu.......hs...AAS-....susKsLsKAoESlADss--AoSsMQpshsTss+AASRsSsVsDDlA....+ASphAEphADAAp....Ksuhhs+hhsuss+losoTsFlsVTSLAEGTKTLPTTlSESVKSsH-lsEQRhKSlENhQtuNL-hYKQ-VRRsQDDIsoRLRDhTossRDLh-l.NRMGQusRLAG....................................................	0	0	1	2
+5631	PF05803	Chordopox_L2		Chordopoxvirus L2 protein	Moxon SJ	anon	Pfam-B_8620 (release 8.0)	Family	This family consists of several Chordopoxvirus L2 proteins.	20.80	20.80	22.80	22.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.00	0.72	-4.36	8	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	40	0	0	39	1	87.00	50	96.83	CHANGED	AEVLhsKL+sIEp-NhhNEKllDCIIpE.IE+ppaalhRPhlRLllDllIllIVls.lhlRllKRNYplLLlhhhhYlhhchhtYhtl	...hEVIsDRLDDIVcQNlADEKFlDalI+t.LE+QsPuILRPllRLhIDlLLhVIVIhIFTlRLVsRNYphLLsLlslslsLslFhah..L......	0	0	0	0
+5632	PF05804	KAP		Kinesin-associated protein (KAP)	Moxon SJ	anon	Pfam-B_8674 (release 8.0)	Family	This family consists of several eukaryotic kinesin-associated (KAP) proteins. Kinesins are intracellular multimeric transport motor proteins that move cellular cargo on microtubule tracks. It has been shown that the sea urchin KRP85/95 holoenzyme associates with a KAP115 non-motor protein, forming a heterotrimeric complex in vitro, called the Kinesin-II [1].  	19.40	19.40	19.40	19.50	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	708	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.38	0.70	-13.27	0.70	-6.61	3	298	2012-10-11 20:01:00	2003-04-07 12:59:11	7	19	178	0	190	401	17	448.30	28	74.69	CHANGED	VKGGSIDVHPTEKALIVNYELEATILGEMGDPMLGERKECQKIIRLRSLNAsTDIAALAREVVEKCKLIHPSKLNEVEQLLYYLQNRKD.....................Spp+SGA+K+EpouKhK.................DPPPaEGsElDEVANINDIDEYIELLYEDlPEKVRGSALILQLARNPDNLEELppNETsLGALARVLREDWK+SVELATNIIYIFFCFSSFSQFHuLIsHYKIGALCMsVIDHELKRHEoWpEELsKKKK...........................ssEEcP.....................................ts...++DYEKSh.........................................KKY+GLlKKQEQLLRVAFYLLLNLAEDsKlELKMRNKNIV+MLVKALDRDNhELLILVVSFLKKLSIasENKNEMuEhsIVEKLsKLlPC-HEDLLNITLRLLLNLSFDTGLRsKMIplGhLPKLVtLLuNDNH+tIAlCVLYHlShDDKsKSMFTYTDCIPMlMKMllEsssERlDLELIALCINLAsNKRNAQLICEGNGL+hLM+RALKF+DPLLMKMIRNISQHDGPoKsQFIDYVGDLARIIops-DEEFVVECLGILANLTIPDLDYEhILpEFpLVPWIK-KLcPGAAEDDLVLEVVlhlGTVAsDDSCAALLAKSGII.SLIELLNAKQEDDEIVCQIIYVFYQMVFHEATREVIIKETQAPAYLIDLMHDKNsEIRKVCDNTLDIIAEaDEEWAKKIKLEKFRWHNSQWLEMVESQQhDDuEQhL.YGD-chE.....PYIpESDILDRPDL	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t........hs...h.hh.L..hNhA.s....p.c.ph..h.p..tt.hlth.....Ll.ch.l..p....p..p..s...h..-..lhh......slshlppLu..h.h...-.N.Ksph...........s..p...s..hltt.Ls+hh................s..p.p..........c........l..p....sh....t....hLhN.loas..s.th.Rp...phlp.sGhlP...hLs.thl.........s.....s..t..p..h..p..................h...s..h.....p.....h....Lhpluh.D.-.p........+..............t.hh.s...T.-..s..l.........................l.hph.................l...hp.s.......p...cl..p......h.p........h......h.hhhN.Lu.s.p.c.........hs...c......s.....pt.L....t.Lh.c...h.h.......p......t...........s....l...l...h...p...h...lRNl...S.....H.....................p.........h.h..p.............a.........lt...s............ls.t....l.t......t........c..p..........c...p....h.hcsluhLtNLsh.....t.........ph..hh........................................................................................................................................................................................................................................................................................................................................................................................................................................	0	77	116	158
+5633	PF05805	L6_membrane		L6 membrane protein	Moxon SJ	anon	Pfam-B_7771 (release 8.0)	Family	This family consists of several eukaryotic L6 membrane proteins. L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily it has now been found that that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 family [1]. Several members of this family have been implicated in human cancer [2,3].	21.80	21.80	64.80	59.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.36	0.71	-4.75	8	302	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	46	0	161	252	0	186.50	40	95.13	CHANGED	MCosKCuRClGhSLlsLALhsIlANlL.LaFPNG-TpYsocs+LSpaVWaFuGIlGGGLhhLhPAhVhluhcpcsCCGCCupEshGKRsuMLoSlluullGllGuuYCllVuulGLs-GPhChs......s.................pstWsYsFss......Tp...GpYLhDsolW.SpCpEPpHlV.WNVoLFSILLsluuLEhlLCLIQVlNGlLGsLCGhCps	........MCotpCu+ClGhoLlsLulhsllsNlL.LhFPsGcsp..h..sp...ps......plop.VWahuGllGuGlhhlhPAhhhlshtp.pssst.C...httt..t.supR......h..sM...h.....tSllhuslGllGusYChllSuluLtpGPhChh......................................sttWtYsFps.......................pt....usYL....h...s....p...ohW.........s....pChEPtplV.WNloLFSlLLsluslphlLChlQllNGllGslCGsCp.........................	0	6	14	57
+5634	PF05806	Noggin		Noggin	Moxon SJ	anon	Pfam-B_7925 (release 8.0)	Family	This family consists of the eukaryotic Noggin proteins. Noggin is a glycoprotein that binds bone morphogenetic proteins (BMPs) selectively and, when added to osteoblasts, it opposes the effects of BMPs. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation [1].	19.60	19.60	19.60	19.80	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.83	0.70	-5.05	6	133	2012-10-02 16:54:34	2003-04-07 12:59:11	7	3	68	1	66	126	1	199.30	36	87.85	CHANGED	hllushhLLl.LslhhctusCQHYYhLRPlPS-sLPll-L+EcPDPlaDP+E+DLNETpL+slLGs.pFDssFMSltsP.c-ptuGs--Ls-.-L....p.sGhMPtEIKsL-F.Ds..hGKK+KsSKKL+R+LQhWLWuYoFCPVlYsWpDLGsRFWPRalKsGSCaSKRSCSVPEGMsCKPsKSsHLTlLRWRClp............................................................R+suhKCAWIPlQYPVIo-CKCSC	.................................................................s...............................................h.........p...Ds......hs....P+.pcL.spphL+phLGs.paDstaMuhs.P...t................t......h...s...u........sp...pl.s...t....p........tsthsp.-.l+....sL..-.h...c...........h.....Gp..+.....+..lu+....Kh+R+.......lp.WLWs.....o..a.....CPVhYsWpDLGsRFWPRYlKhGsC.h..o...c...+..S........CS..hPc..G.MsCKP.....u..cSsplolLRW+.C....p..................................................................................................................t..p..ss..ppCsWI.lpYPlIo-C+CSC..............................................................	0	19	27	47
+5636	PF05808	Podoplanin		Podoplanin	Moxon SJ	anon	Pfam-B_8548 (release 8.0)	Family	This family consists of several mammalian podoplanin like proteins which are thought to control specifically the unique shape of podocytes [1].	29.00	29.00	29.20	29.60	28.90	28.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.03	0.71	-4.68	4	44	2009-09-11 20:54:06	2003-04-07 12:59:11	6	2	33	1	24	54	0	151.90	41	76.82	CHANGED	MW+VPVLhaVLGSAhhWs.ApGuohsRs.......EDDlVTPGspDuhVTPGlEDplsTsGATct..ES.GhAPLVPsppEpsT+..hE-LPTstsosH-tcEppST........TTlpV.....VTSHSt-K.........su-ETpTTscKDGLuVVTLVGIIVGVLLAIGFlGGIIIVVh+KhSGRYSP	.......................................................................................................p..hhhhl.Gs..h...h..u.ttushs.s........EDsh.TsGht.sshshsGh..EDphsTsusopc...pS.uh.os.LVso...sspos.Ts.h.ph..EDhsT.s-ST.sHupcpopSs........Tss.sV.....sTSH..Ss-K................sss-TpTT......l-.KDGLuTVTLVGIIVGVLLAIGFIGGIIlVVhRKMSGRYS..........	0	4	6	8
+5638	PF05810	NinF		NinF protein	Moxon SJ	anon	Pfam-B_8528 (release 8.0)	Family	This family consists of several bacteriophage NinF proteins as well as related sequences from E. coli.	20.00	20.00	20.20	20.00	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.25	0.72	-4.17	4	198	2012-10-03 10:42:43	2003-04-07 12:59:11	7	3	178	0	2	84	1	53.30	71	91.73	CHANGED	MlsP.QspuYEpESltRAL.CAsCuppLcs.ElHVCEcCsAE.Lh.pDsNusMtEE.DDE	............MlsP.QshpYppESV-RALTCANCGQKLHVLEVHVCEcCCAE.LM.SDPNSSMYEE.-D-..........	0	0	0	1
+5639	PF05811	DUF842		Eukaryotic protein of unknown function (DUF842)	Moxon SJ	anon	Pfam-B_7096 (release 8.0)	Family	This family consists of a number of conserved eukaryotic proteins of unknown function. The sequences carry three sets of CxxxC motifs, which might suggest a type of zinc-finger formation.	23.80	23.80	24.00	23.80	22.60	23.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.28	0.71	-4.69	17	215	2009-09-11 00:15:37	2003-04-07 12:59:11	8	5	139	0	146	221	2	122.90	32	78.96	CHANGED	cppppclpsAlpphlsslpcphlhp...........hQtphF+CuscChpDpssoh-plppClEpCpsPltcAQphlpsElupFQsRLpRChhsCpDchcsth..p.s...ctchsp...phEpCsspClDcplsh.LPshhpph+csL	.....................................pttclptulpphlpslp+phl+p........................hQ...tthacCu.ApCCp....D.pps.......ohcpVppClE+CpsP.ltpA.QshlpsELppFQ...........sRL..pRCshpCpD+hcsp...hsss..s.p......c.phtp.............................ph-sCsspClDcahpl.lPshhcch+ps..............................	0	47	72	111
+5640	PF05812	Herpes_BLRF2		Herpesvirus BLRF2 protein	Moxon SJ	anon	Pfam-B_7251 (release 8.0)	Family	This family consists of several Herpesvirus BLRF2 proteins.	25.10	25.10	25.30	35.60	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.57	0.71	-4.29	15	36	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	23	6	0	31	0	118.10	37	90.26	CHANGED	sshohE-LsscLs+LchENKsLK+plppuss............Ps-chLTssQKEslIsusls+LoupApcKIEt+VcppssslVT+pph-cslpslolRlcVShc-.tht..............sps+pRRu+S+o+	.s.shohE-Lstclp+LplENKsLK+pltpuss............ssDphLTsspKEuhIsussstLsutAt+KIEt+V+ppsstlVT+pphpssLtslolRl-VSh--stht............t.sps+pRRutS+oR.....	0	0	0	0
+5641	PF05813	Orthopox_F7		Orthopoxvirus F7 protein	Moxon SJ	anon	Pfam-B_7318 (release 8.0)	Family	\N	25.00	25.00	36.50	36.50	24.60	18.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.93	0.72	-4.09	3	39	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	19	0	0	28	0	73.10	85	94.88	CHANGED	MTLVMGSCCGRFCDAKNKNKNKKEDVEEGGEGYYDYKNLNDLDEFpTRVEFGPLYMINEEKSDINTLDIKRRYRHAIESVYF	..MTLVMGSCCGRFCD...AKNKN......K..KEDlEEttEGCYsYKNLNDLDEu.sRlEFGPLYMINEEKSDINTLDIKRRYRHsIESVYF........	0	0	0	0
+5642	PF05814	DUF843		Baculovirus protein of unknown function (DUF843)	Moxon SJ	anon	Pfam-B_7353 (release 8.0)	Family	This family consists of several Baculovirus proteins of around 85 residues long with no known function.	22.50	22.50	22.60	22.50	22.10	22.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.81	0.72	-4.19	15	82	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	82	0	1	50	0	82.30	40	94.80	CHANGED	MhlhhshlsLIlluFlhsKspshSpLllhlLlLFVlFlhlLplYYl..ps-Ss.stDL.TccsK+lKKKpcLpcAFDAILNKNsSS	...............M.IhhhlLuLlslGhlhs+hcuhssLllhlLlhhllFhllLpl..a..hs..KT-Ss.spcl...o.p.K.....sKpsKKKRplppthDAllNKNpSS........	0	1	1	1
+5643	PF05815	DUF844		Baculovirus protein of unknown function (DUF844)	Moxon SJ	anon	Pfam-B_7453 (release 8.0)	Family	This family consists of several Baculovirus sequences of between 350 and 380 residues long. The family has no known function.	25.00	25.00	29.60	29.50	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.99	0.70	-5.60	22	58	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	52	0	0	57	0	349.20	38	96.85	CHANGED	MosltLFLcIEpLKNpl.DppMphsIWsKFFPLLu-s...solsLshspl.-FLsssAph.upsshsppNAAlsSQa..............sssssssssstss.tpslhNlass....sstsssssssshshppY+psspKllpYYo.usToSo-F+VpDlVtsMlYLu+oP+Y+PLapLLEssh.pc-h-ChPsloscphpsll-hLRsLhshsohplDapslclh+sohs+shN.PlsRaP+Vhlhpsts....lspDKcsol--Lll-Rh-tlppLcsQphlsu...ss+IPaCsDsphIscLl+h.hcsaslsRMaYNAsNoIFYsTMENYAssNCKFslsDYNpIF+shDpl+Ehspp......hppsttuDsLslhLusss	.MSsltLFLcI-pLKspI.DppMphsIWP+hFPLLuDs...sslsLshspl.pFLsssApt.upsshsssNAAlASQa...........ssssssssssssssstpsllNlFss........th.sspssssshshppaRpsspKllpaYoLssToSo-F+VpDlVhsMlYLu+oP+Y+PLapLLEssh.p--h-ChPshossphppllDhLRsLL-hPootlDasslclh+sohs+shN.PlsRas+lhlhpsss....lspDK+sTlEELllERuctIppLcPQQalsu...sscIPaCcDscFIscLlKh.hDsasLsRMaYNAANSlFYTTMENYAluNCKFslcDYNpIFKl.hDslR-hssp......hhtp..sppsDsLNlaLusts............	0	0	0	0
+5644	PF05816	TelA		Toxic anion resistance protein (TelA)	Moxon SJ	anon	Pfam-B_7534 (release 8.0)	Family	This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance [1] and plasmid fertility inhibition [2].	30.00	30.00	30.50	30.70	29.10	28.60	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.91	0.70	-5.73	81	1233	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	1042	0	200	815	46	325.10	30	86.17	CHANGED	pspphupplD.ts.tslhs.aGspsppphupaSpphLsp.V+sp..............-suslGchLspLh....pplcph-sschtt...ppp.shlu+..hhs.+httplpchhs+YpsspspIDpIhtpLpptcspLh+DsthL-phappshpaappLshYItAGchthpclcpph..lsthppcsp....tpt..hthpphs-hpphlptL-pRlpDLphsctlulQshPpIRLlQpsNppLscKIpouhssTlPlaKsplslAlsLtcQ+psscshpsls-sTN-LLppNA-hL+psoh-hs+pspcuslDlETLcps.psllsTl--shpIpp-upppRppsppcLpphpp-l+ppLhphc	..................................htphsppls..tsp.psllsaGsssQ..pphupaSp.phLsc.Vpsp.................-.lu.slGctLspLh.......pplcph.....ss....s-..l........ppc.shhp+....lFp...+...s...c..pslpchhs+YQslssplD+IshpLp+ppspLh+DhthL-pLY-pNppaacsLshaIhA.......Gctph.......pc.......lpsch..lPthppcup......sssQ..hshpplschpphl-cL-pRlpDLphu+plulQosPQIRhIQpsNpsLs-KIpoulhsTIPlaKsphslAlsLh+..Q+pussutctls-sTN-LLppNA-hLKpsslEsA+pspcuhl-l-T.......Lccotpsl...lpslpEohpIppcG+ccRptucpcLtphpp-lKpcLhp..p........................	0	65	133	162
+5645	PF05817	Ribophorin_II		Oligosaccharyltransferase subunit Ribophorin II	Moxon SJ	anon	Pfam-B_7633 (release 8.0)	Family	This family contains eukaryotic Ribophorin II (RPN2) proteins. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly synthesised polypeptides, and is composed of the following proteins: ribophorins I and II (RI and RII), OST48, and Dadl, N33/IAP, OST4, STT3. The family also includes the SWP1 protein from yeast. In yeast the oligosaccharyltransferase complex is composed 7 or 8 subunits, SWP1, being one of them [2][3].	21.30	21.30	21.60	21.30	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	637	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.78	0.70	-6.32	9	364	2009-01-15 18:05:59	2003-04-07 12:59:11	9	4	255	0	205	337	3	381.10	26	91.52	CHANGED	us.u.tshhhlllLsLhssshA.hoso+aLoss-hsRhppshsp....shsDLcsAYYulhsLp.LGhpssD..tppsCchlcsslssSS...h-slFYAupuppsLu.Ccls..lss-scshLhAulp-DuolsQ.IYauVuuLssh.....GLsl...supplhpALp.splSK..........E-olhAshhAhpsAutLuptAs.................Lsshl-clEDhssphDElsGshLQFEsGLssTALhVsusa+LuspluspsslptEQllpLsshhhS+pshpohp-sFsllpAhusLSsN+aalPlllhhsGsutl.pcpslL+lpVTsVLupPLotAsVplspA.sSpoopssllppsshs...hcssl...............apLNhhsspPssGhYshslpl...cu-hRhlhsp.spLKVpV..oscVuIsss-lullDpDp.uhusKpp+VsaPsKscsshsADSpQphsLpFQLhDssoGtslsPHQsFV+L+NpcTtQEllFVAEPDSpphYKFELDsutRtp-.FsphSGpYsl.LIVGDAslENshLWNVAcl.LKFs-......c.ssushpupshatPKPEIpHlFRpPEKRPPphVSssFTALlluPLllLhlLWhKLGsNlSNFshSsu....sIlFHlGhuAhLsLhhlaWh+LNMFpTLKYLulLGshTFLsGNRhLuphAs+p	............................................................................................................................................................................................................................................................h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.h.l.....s....t..s...t.....h.p.sHQ.sFlhl......t.......p...p..o.t.-h.a.s.h............p.p......t....t.....hp..hp...l.sh..tph.....p.h......s..s......hph...lll..Gs.ss...hp..s..shh.hpl.........spl.lph.st.............................t...s..s.s.h....t....s..has............p.EIpHlFRts..tKpPPthlS.sFs.......s.h.l.......lssh.hhLhhhW.hp.l..G.......s...N..l.s.p.h....shu......s....................sh.hFa.h.u....hu.uh.h....s....l....h...h...l...a...ahphshFpTL.hhhhlushshlsGs+hLtp.t...............................................................	0	69	112	167
+5646	PF05818	TraT		Enterobacterial TraT complement resistance protein	Moxon SJ	anon	Pfam-B_7686 (release 8.0)	Family	The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between an Escherichia coli and its surroundings [1,2].	28.30	28.30	28.60	29.40	27.90	28.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.37	0.70	-4.92	15	363	2009-09-13 11:01:34	2003-04-07 12:59:11	7	3	289	0	41	252	5	196.60	62	87.08	CHANGED	sL-VpTKMSpTIFL-PVsssc+pVYlpl+NTS...D+sl.slcspltssLpu+G..Y+llssP-cApYhlQsNVLps-Kts.ss.upshLpsGatG...AsuGAAlGsuluuhs..SuuuGuslGhGLAG....GLlGhsusAhV-DlsYpMlTDlQIpE+scssVhsspt....puslKpG......................sSuspsQ.TpocsoshpcY+TRVVosANKsNLchEEApPlLEcpLA+sIAGIF	.....................NL-VpTpMS-TIWL-P....uuc+TVaLQIKNTS.....D.K-h...s...LpuKIssAlpAKG..YpVVouPDcAaYWIQANVLKADKMDLRE..uQG.aLspGYEG...AAsGAA.LGAGIT..uYN...SsSAGA.TLGVG..LAu..........GLlGMAA.D.....AMVEDlNYTMITDVQI.....uERT..+..s.sVpTDN.....VAALRQG...........................TSGuKlQ..TSTETGNpHKYQTRVVSsANKVNLKFEEA+PlLEDQLAKSIANIL............................................................................................	0	9	21	33
+5647	PF05819	NolX		NolX protein	Moxon SJ	anon	Pfam-B_7801 (release 8.0)	Family	This family consists of Rhizobium NolX and Xanthomonas HrpF proteins. The interaction between the plant pathogen Xanthomonas campestris pv. vesicatoria and its host plants is controlled by hrp genes (hypersensitive reaction and pathogenicity), which encode a type III protein secretion system. Among type III-secreted proteins are avirulence proteins, effectors involved in the induction of plant defence reactions. HrpF is dispensable for protein secretion but required for AvrBs3 recognition in planta, is thought to function as a translocator of effector proteins into the host cell [1]. NolX, a soybean cultivar specificity protein, is secreted by a type III secretion system (TTSS) and shows homology to HrpF of the plant pathogen Xanthomonas campestris pv. vesicatoria. It is not known whether NolX functions at the bacterium-plant interface or acts inside the host cell. NolX is expressed in planta only during the early stages of nodule development [2].	25.00	25.00	238.20	32.40	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	624	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-12.97	0.70	-6.16	5	94	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	40	0	19	88	1	324.40	28	76.06	CHANGED	psDSsLhSohDsL.hp.hapLhuulppssp............ssusuhsA.sssuusD.QusQP.p.tT........Fs.tcl+tscAPPshpGS.oVTWpGGTLosoELQIlusLNsHKDphslpatpLpDKINDPsTPPDLKSALQuLpKDPpLF.AIGSQGDG+hGGKIKutDLh-FucpH.QV............................lTWsuGTLspspLEIhShLspH+D.hPlcauplptKINDPuTPPph+tAlpuhpQsPt.hhAhss....................................................h.sPlpupplTWsGGoLopsELpIVAsLNRHKDhCPlpWpsLpsKspDPuhPPDLKAAlpuLQQDPcLFaAIGSQGD.G+CGGKITAKDLS+FS..cHHuQVApYs-pQAcuYsQNYIPSDSs-sscPSVMTENDAMRELYRYSDYLPKcLsh-sFKQIVDGDScTKKCPPQVIAAAQYFlsHP-EWKuL..huGsp-+VuKsDFLQ+ASSuMHLTpsELcTLcTINSHQ-sFFGDGp-lTRDKLAoMucD-SLDPAVR-AAoQLLuDPLLFGLLNNAITGYKT+HuFFsFGGGHTVDSGsISpKDFp+FYssMTuANKTVQpPKTHsAsSsApQcAVADMhMG+ADQPDIKusKKsGGAFp+ulc-hLKh.SKlhDhhSsulSALuuIPllG	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	8	10
+5648	PF05820	DUF845		Baculovirus protein of unknown function (DUF845)	Moxon SJ	anon	Pfam-B_7739 (release 8.0)	Family	This family consists of several highly related Baculovirus proteins of unknown function.	21.20	21.20	24.30	23.20	18.50	15.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.61	0.71	-4.36	20	63	2009-09-11 05:36:17	2003-04-07 12:59:11	6	1	59	0	0	61	0	118.20	55	54.02	CHANGED	lsRlKYDucLLl+YLFDstspt.............ssssNlIKICKV+V+KTsGolLAHYYA+IplSNGYsFEFHPGSQP+TFQslH...o-GplltlhlLCDECCKcEL+sFV-GENsFNlAF+NCEoILCKR	..........................sRlKYDu-LLl+YlFDshss..............spshNVIKlCKV+VKKTsGolLAHYYApIplSNGasFEFHPG..S.QP+TFQslH......oDGhlItlhlhCD-CCKcEL+palcGENsFNlAF+NCESILCKR.....................	0	0	0	0
+5649	PF05821	NDUF_B8	NDUFB8; 	NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)	Moxon SJ	anon	Pfam-B_7830 (release 8.0)	Family	This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits [1].	20.40	20.40	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.26	0.71	-4.62	10	254	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	204	0	156	248	0	145.40	30	83.01	CHANGED	+ulhsupplsp..sssulhhpusRsAuGh.sKDhhPGPYP+TsEERtAAAKKYshRsEDYpPY.PDDGhGY.GDYPKLP.shohccRDPYYsWDaP-LRRNWGEPlHhDhDhYscsRls....ou.sshsWpoMshalhuFlGhM...lhhaahsEsaPsY....pPVusKQYPasshhh..hsDspK.P..VsHYsF	................................................t..........................................................-Ypsh..sD..-shth.GDYPplP.shs.....pppRDPahsWDcsp.RRNaGEPlH...hD...hD...h...a...t..s..phs....pss..s...h..s......hth..hh..h...shluhh.....hhhhhh.hp...h.........pPshs+paPht............................................................................................	0	51	78	121
+5650	PF05822	UMPH-1		Pyrimidine 5'-nucleotidase (UMPH-1)	Moxon SJ	anon	Pfam-B_7840 (release 8.0)	Family	This family consists of several eukaryotic pyrimidine 5'-nucleotidase proteins. P5'N-1, also known as uridine monophosphate hydrolase-1 (UMPH-1), is a member of a large functional group of enzymes, characterised by the ability to dephosphorylate nucleic acids. P5'N-1 catalyses the dephosphorylation of pyrimidine nucleoside monophosphates to the corresponding nucleosides. Deficiencies in this proteins function can lead to several different disorders in humans [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.47	0.70	-5.06	11	291	2012-10-03 04:19:28	2003-04-07 12:59:11	7	4	132	17	172	406	7	214.30	40	78.27	CHANGED	hTLS+ath.NGcRsPTsasIh-ss.p.ls--s+pchppLac+YaPIEIDPpholEEKhPaMlEWWsKoHsLLhpttlp+scIsclV+cscstLRDGhcphFcpLpphslPshIFSAGlGDllEpllRQA.sVhasNlKVVSNaMpFD-sGhLsGFpu.lIHTaNKNsosLc.sopYacpl.............csRsNIILLGDSlGDlsMADGVs......sspsILKIGFLND+VEcpl-+YhcuaDIVLlcDpThDVssuILphIh	....................................................................hTLo+ath.sG.p+s.sosasllcss.thlsp....-hppchhpLhppYaP..IElDPphohcEKhshMhEWasKuHsLl.hpttlp+tpltphVt..c.u....s..hhLR-..G..hcphFppLpppslPlhIFS.AGlGD.l.l.Epll+Q..................t......ss..h...a..............sN.l+lVSNa...MpFs..-s............G..hL.p.......G.......F....cu..p.L.I..HsaN.K....p.p..ss.l....p....ss...t..aa..p..p..l...............p.s.+...sN.....l.lLLG....DShGDlpM..uDGl........sh.pplL+IGFLN..-c...l..-......c.......hcpYh...csaDIVLlpD.p..ohclsptllptl.........................................................................	2	63	82	126
+5651	PF05823	Gp-FAR-1		Nematode fatty acid retinoid binding protein (Gp-FAR-1)	Moxon SJ	anon	Pfam-B_7852 (release 8.0)	Family	Parasitic nematodes produce at least two structurally novel classes of small helix-rich retinol- and fatty-acid-binding proteins that have no counterparts in their plant or animal hosts and thus represent potential targets for new nematicides. Gp-FAR-1 is a member of the nematode-specific fatty-acid- and retinol-binding (FAR) family of proteins but localises to the surface of the organism, placing it in a strategic position for interaction with the host. Gp-FAR-1 functions as a broad-spectrum retinol- and fatty-acid-binding protein, and it is thought that it is involved in the evasion of primary host plant defence systems [1].	25.40	25.40	26.00	26.00	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.70	0.71	-4.26	11	100	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	26	1	68	82	0	146.00	26	76.31	CHANGED	sIPpEaK-LIPpEVs-ahpslTsEEKssLKElh+s.apcaKsE-EhlsALKEKSPsLapKAcKLcshlKpKl-uL.ss-AKAFlpclIApuRpl+sphlsGpKPol-pLKphscshlscYKALos-AK--LpcpFPhlsphhpsEKhQslhsphLs	..........................tpaKphlPt-lhphhpslos--Kthl+...-lhps.....a......t.....p.....a..p.....sp--h.lssLKcKSPpLap+hpcl..pshlcpK.lssL..ss-u+tFlccl........ls..ps+.p.l.hsphhs...Gp.p..s......h....p.c...l....Kph......scphhspacuL..spp..sKp..-Lcps..FPtlsphhpscchp..................................	0	33	42	68
+5652	PF05824	Pro-MCH		Pro-melanin-concentrating hormone (Pro-MCH)	Moxon SJ	anon	Pfam-B_7863 (release 8.0)	Family	This family consists of several mammalian pro-melanin-concentrating hormone (Pro-MCH) 1 and 2 proteins. Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic peptide that was first isolated from the pituitary of teleost fish. It is produced from pro-MCH that encodes, in addition to MCH, NEI, and a putative peptide, NGE. In lower vertebrates, MCH acts to regulate skin colour by antagonising the melanin-dispersing actions of small alpha, Greek-melanocyte stimulating hormone (small alpha, Greek-MSH). In mammals, MCH serves as a neuropeptide and is found in many regions of the brain and especially the hypothalamus. It affects many types of behaviours such as appetite, sexual receptivity, aggression, and anxiety. MCH also stimulates the release of luteinising hormone [1].	20.60	20.60	20.80	20.90	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.92	0.72	-4.49	2	63	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	45	0	30	57	0	76.60	70	52.87	CHANGED	h.SppstpKHNFLNHGLsLNLsIKPYLALcGSVAFPAENGVQsTESTQEKREhGDEENSAKFPlGRRDFDhhp...s+hYpsh.pl	.........................+ssGSKHNFLNH.GLPLNLAlK..PYLALKGSVA.FPAENGVQNTESTQEKREhGDEENSAKFPIGRR..D..FDMLRCMLGRVYRPCWQV..........	0	3	5	14
+5653	PF05825	PSP94		Beta-microseminoprotein (PSP-94)	Moxon SJ	anon	Pfam-B_7865 (release 8.0)	Domain	This family consists of the mammalian specific protein beta-microseminoprotein. Prostatic secretory protein of 94 amino acids (PSP94), also called beta-microseminoprotein, is a small, nonglycosylated protein, rich in cysteine residues. It was first isolated as a major protein from human seminal plasma [1]. The exact function of this protein is unknown.	22.00	22.00	22.40	22.00	21.90	21.90	hmmbuild  --amino -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.48	0.72	-3.71	6	122	2012-10-01 23:42:56	2003-04-07 12:59:11	6	1	52	7	63	145	0	86.20	31	74.93	CHANGED	uC.lI.pchlPs-pocECTDLKGNKHPLNShW+TcNCEhCoCccspIoCCThsupPVGYD+++CQ+IFpKEsCpYSVVEKpsPuKTCsVsuWlh	............................................ttChD.h.c.Gp.h.+.slsopWpocsC.pCoC.h.c.s.G.lsC...Csts.tpPlsasp.ppCptlhcpcsCpaplVcKp-PppsCt...................................	0	8	10	18
+5654	PF05826	Phospholip_A2_2	Phospholip_A2; 	Phospholipase A2	Moxon SJ	anon	Pfam-B_7918 (release 8.0)	Family	This family consists of several phospholipase A2 like proteins mostly from insects [1].	20.20	20.20	20.20	20.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.62	0.72	-4.05	23	357	2009-09-11 05:31:23	2003-04-07 12:59:11	7	7	104	1	215	359	0	92.80	33	37.16	CHANGED	lhPGTKWCGsGNhAss.YsDLGstpcsDpCCRsHDpCsphIsu...hps+aGL.pNsshaTh.+CcCDppFpsCLps.ssssh.........uphlGphYFslhps.CathppPp	...................................hPGThWCG.Gs...Ats..hp..-L.G..h...ttsDtCCR...p..H..D.p.Cs.p..h.Its...hps.caul.pNhpha.T.............hp.....HCsCDp.chtpCLpt...hssth.........uphlG.haFs.llph.CFtht..t..............................	2	73	90	162
+5655	PF05827	ATP-synt_S1		Vacuolar ATP synthase subunit S1 (ATP6S1)	Moxon SJ	anon	Pfam-B_8145 (release 8.0)	Family	This family consists of eukaryotic vacuolar ATP synthase subunit S1 proteins [1]. It also contains BIG1 ER integral membrane proteins which are involved in cell wall organisation and biogenesis [2].	37.60	37.60	37.80	37.90	37.50	36.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.70	0.70	-5.09	31	258	2009-09-11 20:52:15	2003-04-07 12:59:11	7	4	174	0	154	240	0	286.90	23	83.89	CHANGED	ssPhllhSspt....h...hssssuphpsssplhshhpphLusCsoctYlhlsQP.......GlpssDFsttps.........hspLpshhptussslthshl........s.lshppLtphlpcpCss.sthlsssstp..ph.th.....csRllhlphs.Lssst......ppRtphLpspDphltpllsplsSsp..YT..............llhso...t....................................httpssptslatt.hsshsts.......hch-hp..................p.........p..pshssp...................................................................spppsssph..hhtcaQ............................aaosGlahullsslhhlslLhhulphlhS	...........................................................................................................................tsPhhhhSspt...............s.ppup.ltos.pl.s..hlp.hLp...s.spsshlhl.Qs.......tlphpDFsthts..........hspLp..ptlt....u.s..sslhhshl........s.hs.hspLtphlp.cphs....s..shhlshts.t...ph.t.........................stllhlchs.hs...ts..........ttpphLpt.s.D......phlsp.lls.pl.upp...YT................slhTuh...s...............................................................p.t..shh...hp..hp.s..............th-hp..........................................h.p...............p....t.tsp............................................................................................................................sspspss.h.......hhpcaQ................................................................................................FFoPG.IaMullsslhhlhIhhhGlphl.p............................................................................................................	0	29	69	121
+5657	PF05829	Adeno_PX	Adenovirus_PX; 	Adenovirus late L2 mu core protein (Protein X)	Moxon SJ	anon	Pfam-B_8179 (release 8.0)	Family	This family consists of several Adenovirus late L2 mu core protein or Protein X sequences.	25.00	25.00	57.40	57.40	18.60	17.60	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.25	0.72	-4.46	18	117	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	86	0	0	63	0	44.30	69	55.74	CHANGED	pppRp+thp+ch+GGF.LPALIPIIAAAIGAlPGIAusAltAupt	...............+RRRRAhpRRLpGGF.LPA.LIPIIAAAIGAIPGIASVAlQASp.h	0	0	0	0
+5658	PF05830	NodZ		Nodulation protein Z (NodZ)	Moxon SJ	anon	Pfam-B_8202 (release 8.0)	Family	The nodulation genes of Rhizobia are regulated by the nodD gene product in response to host-produced flavonoids and appear to encode enzymes involved in the production of a lipo-chitose signal molecule required for infection and nodule formation. NodZ is required for the addition of a 2-O-methylfucose residue to the terminal reducing N-acetylglucosamine of the nodulation signal. This substitution is essential for the biological activity of this molecule. Mutations in nodZ result in defective nodulation. nodZ represents a unique nodulation gene that is not under the control of NodD and yet is essential for the synthesis of an active nodulation signal [1]. 	24.90	24.90	25.00	27.60	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.27	0.70	-5.85	6	136	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	108	5	13	135	8	169.20	59	89.55	CHANGED	pp-RaVlSRRRTGFGDCLWSLAAAWcYApRTGRTLAIDWRGSCYL-pPFoNAFPVFFEPIpDIuGVpVICDDpINphSFPGPFFPsWWNKPSI-ClYRPDEQIFRERDELs-LFQAQ-Ds-ANTVVCDACLMWRCDE-AERpIFcSlpsRsEIpARIDAlYpEHFpGaSlIGVHVRHGNGEDIMDHAPYWADs-lAL+QVCsAIccAKALsHs+PV+VFLCTDSApVlDplSuhFPDLFslPKpFQAcQAGPLHSAsLGl-GGhSALlEMYLLuRCDTVIRFPPTSAFTRYARLhVPRVIEFDLscPuRLllIDcsupphsA	............................................................LAuAWpaAppTGRTLsIDWRGSCYLDpPFoNAFPVFFEPVp-IAGV.VICDDcINphSFPGPFFPsWWN....+PoIDClYRPDEQIFRERDELcpLFQupcDs-ANTVVCDACLMWRCDpEAERpIFRoIKPRsEIQARIDAIYcEHhts...lG..........................................................................................................................................................................................................................................	0	6	10	12
+5659	PF05831	GAGE		GAGE protein	Moxon SJ	anon	Pfam-B_8207 (release 8.0)	Family	This family consists of several GAGE and XAGE proteins which are found exclusively in humans. The function of this family is unknown although they have been implicated in human cancers [1].	20.80	20.80	20.80	20.80	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.48	0.71	-3.94	7	212	2009-01-15 18:05:59	2003-04-07 12:59:11	6	3	21	0	48	231	1	97.00	41	61.49	CHANGED	MuaRuRop.R.sRPRRslpssph.lGshl..E.Po-E....pPppEEPPTcSQD.sPuQERE.DpGAuthQssclEAD.QELspsKTGsEsGDGPDsptthLPp.EphKhPEuG.....-tpsQV	............MshRuRop.R.sp..s..R.t..ps.sp..lGshh.pp...o-E.....pspptEPPTcsQs.ssupctp.spGAst.sQs.sc....hEAs.QEh..shsKsGsEptDGPDlpttslPs.EpsKhsEsG..............	1	30	30	30
+5660	PF05832	DUF846		Eukaryotic protein of unknown function (DUF846)	Moxon SJ	anon	Pfam-B_8404 (release 8.0)	Family	This family consists of several of unknown function from a variety of eukaryotic organisms.	20.50	20.50	21.80	20.70	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.90	0.71	-4.48	59	469	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	293	0	302	430	4	135.80	41	65.60	CHANGED	pssHP..h....shhhalhh+hsullhYlh...sshh.......ps.alhpF.llhllLluhDFWhlKNloGR.hLVGLRWWs-ss.......p..cG...............p.spWhFEotsss....t.h.ssh-.............uplFWhslhssshh...............Wllhslhslhphphha...lhlshluhsLshsNhhuah.+C	..................................................................h..tHPlsshFHlhF+suAllhYlh.sshF...........sss.FlhtF..lhhlLLLuhDFWsVKNloGR.lLVGLRWWNplc..............-.-G.................c.SpWlFESpcss.......pph.sts-..................u+lFWluLhssP..ll...............Wllhshh...sl...hph.p.hpW...LhlVhhulsLshsNlhGah+C.....................................	1	111	166	246
+5661	PF05833	FbpA		Fibronectin-binding protein A N-terminus (FbpA)	Moxon SJ	anon	Pfam-B_8577 (release 8.0)	Family	This family consists of the N-terminal region of the prokaryotic fibronectin-binding protein. Fibronectin binding is considered to be an important virulence factor in streptococcal infections. Fibronectin is a dimeric glycoprotein that is present in a soluble form in plasma and extracellular fluids; it is also present in a fibrillar form on cell surfaces. Both the soluble and cellular forms of fibronectin may be incorporated into the extracellular tissue matrix. While fibronectin has critical roles in eukaryotic cellular processes, such as adhesion, migration and differentiation, it is also a substrate for the attachment of bacteria. The binding of pathogenic Streptococcus pyogenes and Staphylococcus aureus to epithelial cells via fibronectin facilitates their internalisation and systemic spread within the host [1]. 	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	455	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.56	0.70	-5.95	114	2820	2012-10-02 21:21:44	2003-04-07 12:59:11	6	21	2261	20	808	2533	427	354.70	22	68.70	CHANGED	DGhhlpullpELppp......LhsuRlpKlhQPppp...-lhlslR.s.tpppht.LLlSupsshsRlplT..pt.shtsPtsPssFsMlLRKaLpGutlhpIcQ.hsh-Rllplplpsc................s-h.Gctthhp........LllElMG+HSNllLl-pps....pIl-ul++ls.p.sp.hRslhPGptYhhPPs.pphsPh..phpp.c.phhph....l............tttls+tLhppapGlSshhucEls....hcss.......p.....h...thpplhpthpphhpplp.............................thpP..phhh.t...........psassl.s...hp....t.......ppasoluphL-paYtp+sppc+lp..p..pppcLp+h...lpsplc+tpcKlpphpcpLppscpu.....-pa+hhGELLpshlatl.ppGhpp.lpl.saas...sp...........................tl....pIsL-sphoPspNAQcYac+YpKhKpuhptlppplcpscpElpYL-sl.splp.............pu.s.p-lp-I+cELhppGYl+.....cppp.cpc+ppp	...............................................................................................sh.htthhpp.lp........lhst+lppl...p.........p.p.............pl.....hh.lp...t..........t.......t...........p..h.......L..ll.sh...........h.sRlpho........p.....t...h.....t...........s...........s.......s.s.........FshhLRKalpsuhlpplpQ.h.......t.-Rllphp.hppt..................................................................h.....hp.........lhlE.lh.G+.uNl.lLs..-........p...........p...........p....p........I.....l-sh..+.+.ls.p...........sp.......hR......lhs.u...Y............h........P........s.t.......t.........t.h.ssh.................phpt.t....thhph.....................h........................p...l......p......h....uh...u..hspch................h.................................................................................t.h.......t......t...h...t...t.hh.t..........................................................................................s...............................................a..h......................ht...........................atsh..sphl-taa..t....t....p.t..........p...p....p....c..lp.....p........ptppl....ch..........lppp...h.p...+.pp+lt.p.h.p..p...p.h.t.t.sppt...............cph.p..hu-ll.....ts.hh...tl...........p....s.........p.p...hpl.....sahp....tp....................................................................................................l..tI.L.s...t.h..ostpNA.ptYa....p....p....h.p....K..h....+p...t.h....p....hl....ppt..lp..ts.p.p.pl.t.a..hpp.h.t..lp................h...s...tl...ht.c.h...........................................................................................................................	0	311	543	709
+5662	PF05834	Lycopene_cycl		Lycopene cyclase protein	Moxon SJ	anon	Pfam-B_8336 (release 8.0)	Family	This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclisation of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare [1,2].  	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.23	0.70	-5.54	20	839	2012-10-10 17:06:42	2003-04-07 12:59:11	7	25	565	0	264	2841	3261	323.20	23	76.95	CHANGED	DllllGuGsAGhtlAtcl.....u+suLpVsLl-suPsh.hssNa.sWsschpDLu......LtsslpasWs.sttVths-pspphhu...huYuplspctLcctlhc+hs.tsushhhsu+Vsplspsss.......hshssGp.....pItuRhVlDupG.ssss......suhpsuhQshhGlElcl-ps.aDssthllMDaR.....spQp......cs.sFlYshPhSssRlhlE-TphussssLsh-sL+p+lhshhcs.hGlplpclhc-EpuhIPl..GGslssh.pc.....shshGssAGhsHPuTGYSlstulutAs....slAp.hls.s..............shuhpshtshasp-RtcpcsFF.hhshhLhlphch-uppphhcpFacLPpthhptFhuu+LolsDhlhluht...h.slssssshh	............................................................................................................DllllG.uG.sAGhslAtpl.......................s..p..h...u...l....p...V.....h.......h.....l...............-....................s...........p.......h................h........s......s......s.....h.......s...........W....s..........t..h..p..s.hs......................................l.t..s..h....l......p.....t...p.......W..........p.....s......s......h........l.....h.....h.........s....s.....t......p...h...t.....hs...................hs.Y.....s.........h...........l....s...........p.p..........t.........L..c..p.......t..h.......h.p......c...s.....h........t......t.u.......l.....p..h......h..p...u..p....V....t...p...l.htpss..........s.hl.h..s.s..s..Gt.......................pl...p.A..phVlDA...sG...hstp...................tsh..s...u....h......Q....h....h.......h.......G..h...h..c........s......p..t............s....a..s.........p....p.......h.h.h...M.D..hR............s..............................ths..s.F.h.....Y.....sh.....P..h.u.....s..s...p....h....h..l....E.....T.....hs..........s....p.s....h...s....h..pt.hpp..thhth.l..p........p....h..........sh..p....h.....p...l....c.........c.E....h...s.h.......lPh.....t..s....s.....h..pt...............hhth.Gssuuhs+Pso..G....Y....h....s....ts.tt.us........hlup..hh.ht..............................t.t....th..h.th...hsh.t..hh..h..p...t....h.h....hhs.......hhhth....tth....hh.p.ha..h...tl.....hh..tFhstt.....t.h.h.................h....................................................................................................................................................................................................................	0	73	187	242
+5663	PF05835	Synaphin		Synaphin protein	Moxon SJ	anon	Pfam-B_8588 (release 8.0)	Family	This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles [1]. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin  transmembrane regions that reside in opposing membranes prior to fusion [2].	21.10	21.10	22.90	22.60	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.95	0.71	-4.02	8	251	2009-09-10 22:35:29	2003-04-07 12:59:11	7	3	90	11	158	207	1	124.40	40	88.74	CHANGED	suFlsKQhlGsQLssVputLGsc.t-EGDs...sAp......EE-tEhpEAlREtEE+RKtKaRKMEpEREpMRQGIRDKYuIKKKEE......pp-spsh.....EGpLGRcKKoPcElAsEAsps----ttpuhhspslcpLss.plp-lhsK	.................hsFhhKphlus.thKshst..h....l....GG-.......--t-s....pAp.................cc.EEhQctlt..pp...c.c.......ERcAcas+hEAER.EphRppI..RDK........YtlpKpEp.......c-sphphA........l..s.c.s..hc.....Ah.stpsp.-.E.E..E.p.p....s.l.s.lp.l.s.slpphhpK..............................................................	0	32	47	91
+5664	PF05836	Chorion_S16		Chorion protein S16	Moxon SJ	anon	Pfam-B_8659 (release 8.0)	Family	This family consists of several examples of the fruit fly specific chorion protein S16.  The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary [1]. 	25.00	25.00	40.00	39.50	23.30	20.20	hmmbuild  --amino -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.64	0.72	-4.16	5	37	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	17	0	8	39	0	107.10	79	78.20	CHANGED	GSGu.YuDVVKssETAEAQAAALTNAAGAAASAAKLDGADWYALNRYGWEQGRPLLuKPYGPLDsLYAAALPPRSFVAEIDPVFKKSsYGGuYG-+olTLNTGAKLAVuAl	.....G.YGASYGDVVKAAETAEAQASALTNAAGAAASAAKLDGADWYALNRYGWEQGRPLLAKPYGPLDpLYAAA.LPPRSFVAEVDPVFKKSpYGGSYGp.pAaLpTsSKLuVVAI..........	0	1	1	5
+5665	PF05837	CENP-H		Centromere protein H (CENP-H)	Moxon SJ	anon	Pfam-B_8705 (release 8.0)	Domain	This family consists of several eukaryotic centromere protein H (CENP-H) sequences. Macromolecular centromere-kinetochore complex plays a critical role in sister chromatid separation, but its complete protein composition as well as its precise dynamic function during mitosis has not yet been clearly determined. CENP-H contains a coiled-coil structure and a nuclear localisation signal. CENP-H is specifically and constitutively localised in kinetochores throughout the cell cycle. CENP-H may play a role in kinetochore organisation and function throughout the cell cycle [1]. This the C-terminus of the region, which is conserved from fungi to humans.	23.00	23.00	25.30	25.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.10	0.72	-3.86	16	119	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	108	0	88	130	1	106.20	27	46.14	CHANGED	LShthhphppsppsspccLpslchcpLpl+ppsppllpElhphsccpcshcc....s.chpppLcplcuch+po+p+hcshpslhpulllGSGVNWAEDccLpslVLc.p	...........................................................................ls..h.p.tptptsh.ccL.tslchcplplpppspphhtclhplppcpcpppc.....................s.chppplcplcpphctp+pphpsl+plhp.ullluSGVsWAcDtpL+clVLc..........	0	18	34	60
+5666	PF05838	Glyco_hydro_108	DUF847;	Glycosyl hydrolase 108	Moxon SJ, Bateman A, Eberhardt R	anon	Pfam-B_8737 (release 8.0)	Domain	This family acts as a lysozyme (N-acetylmuramidase), EC:3.2.1.17. It contains a conserved EGGY motif near the N-terminus, the glutamic acid within this motif is essential for catalytic activity [1]. In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion [2,3]. It is frequently found at the N-terminus of proteins containing a C-terminal Pfam:PF09374 domain.	21.20	21.20	21.40	21.60	20.10	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.63	0.72	-3.86	20	820	2012-10-03 00:09:25	2003-04-07 12:59:11	7	13	534	9	151	587	217	85.40	39	42.35	CHANGED	phhsplls+EG............GYsscPcD.GG.......s.....TsaGITttThcshuh............su-l+sLTc-pAh.sIYctcYWp+h+hDpls...tuluhplFDsuVNpG	....................................hhstllucEG............G..YV....sc..PpD.GG............s.......TpaGIT.sThpAhuh......................................tu-h+s..L.T..c..spAh...pIacppYW..psphDpls...tsluhplhDsuVNtG...............	0	33	91	125
+5667	PF05839	Apc13p		Apc13p protein	Wood V	anon	Wood V	Family	The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators Members of this family are components of the anaphase-promoting complex homologous to Apc13p [1].	21.50	21.50	21.80	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.93	0.72	-4.01	7	186	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	177	0	130	157	0	81.00	31	56.67	CHANGED	hDup...hphctsths.lhssapp...DpLP..-Dlh.lP.scL.shp..t--.hhPDpcAshGhp+totpp+..................EssWpDLuLt-Lhppushlss	..............................hDSp....hphpt.hhsll.-tWpp...Dp.LP.h-Dlh...lP...sp..h.................................P-tcts.Gh..s..+to.ppp.........................................E.tWpDLuLppLhpss....s...........................................	0	29	57	98
+5668	PF05840	Phage_GPA		Bacteriophage replication gene A protein (GPA)	Moxon SJ	anon	Pfam-B_8738 (release 8.0)	Family	This family consists of a group of bacteriophage replication gene A protein (GPA) like sequences from both viruses and bacteria. The members of this family are likely to be endonucleases [1,2,3].	20.90	20.90	21.00	20.90	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.27	0.70	-5.75	11	1036	2012-10-02 18:54:06	2003-04-07 12:59:11	8	4	599	0	93	1026	15	329.10	36	50.68	CHANGED	s-hcchAschAsthpthhpphs-.........p...h.tthhpsYphlAph.shshslp...Pth...........pt...tp.h.sslhRhhs-cWWhcpLpphththhEp..hshs.Vs+ptusYsSpcslp-hRtppptsh-alKuhslcsE-u..pphsLt-hhhtS.SNPthRRsEhMsRl+GhEchAcppGhhulFhTLT.APS+aHAhhcss....+.......W.s.As.Pp..-spcYLssla.shhRAchp+ttlphaGlRVsEPHHD..............GTsHWHhlhFhps..............ccpcplsplhpsa........Alc.DpcEht.cGhh.................psRh+uEhlcspKGoAsG.YlAKYIuKNIDuptltt........chsc-o.u+php-suts..VhuWsphaRIRQFpFaGhsshtsaRELR+hsst	....................................................................phpphus.hus.h......hh.pthh....................t.............p..h..h.p.haphlut...shthp...h....Pha........................tt........p.h.sulhRhhsscWWhcpLhh.phphpEt.hh.A.hs.V............s+..c..............t......osYsSpcslpchRtp+pt.sh-ah+uh.l.s--u...phsL.shh.to.uNP.hRRsEhMsphtGhEhhActcG.h.ulFhTlT.sPS+aH.u....s..h....p.......s..G.....t............psp.................Ws.s...ut...s+....sspcYLs.sha..uhh....Rtthp...c..t..s.......l.........p....h.......aGhRlsEPHH.D..............GTsHWHhhhFh+s.........................................cp.hcpl.....ss.lhcca..........Alc-..D.p.cE..htpss.........................................................tsRF+uEhl......cs........p...+Gs.ssu.YIAKYIuKNlD...ut.u.lst.....................phsc-o....G+sh......p-...o...scp......shuWAphaRlRQFp.h.Gh.s.s.htsaRELRplst.t............................................................	0	3	38	69
+5669	PF05841	Apc15p		Apc15p protein	Wood V	anon	Wood V	Family	The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators Members of this family are components of the anaphase-promoting complex homologous to Apc15p Swiss:O94688 [1].	23.80	23.20	24.40	24.40	23.70	23.10	hmmbuild  --amino -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-3.39	27	114	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	113	0	84	115	0	115.10	25	31.83	CHANGED	sapLWhs...................ssps.pssppppsssttspp.................shhpsss.ss.......tsh..tt..tsssplusLhhcEcthctRcpsItshGaoaI+PhGlsKTMhth+..ccc......tEpEct.tsu	......................................hpLa.s......................s....pstpppt...p.........................h.p.st.ss..t.s...h..tttt......hppspLspLhh-EpthcpRctsIpshGasWl+PhGlsKTMhph+....EEc................tEpcEt.t........................	0	14	38	68
+5670	PF05842	Euplotes_phero		Euplotes octocarinatus mating pheromone protein	Moxon SJ	anon	Pfam-B_8825 (release 8.0)	Family	This family consists of several mating pheromone proteins from Euplotes octocarinatus. Cells of the ten mating types of the ciliate Euplotes octocarinatus communicate by pheromones before they enter conjugation. The pheromones induce homotypic pairing when applied to mating types that do not secrete the same pheromone(s). Heterotypic pairs (i.e., those between cells of different mating types) are formed only when both mating types in a mixture secrete a pheromone that the other does not. The genetics of mating types is based on four codominant mating type alleles, each allele determining production of a different pheromone. The pheromones not only induce pair formation but also attract cells [1].	25.00	25.00	25.80	69.00	23.50	22.60	hmmbuild  --amino -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.24	0.71	-3.81	6	8	2009-09-11 05:26:38	2003-04-07 12:59:11	6	1	1	0	0	9	0	134.00	47	88.96	CHANGED	FKMTSKVNTKLQSQIQSKFQSKNKLASTFtTs.phK..s..-s.....hTGC.sTN..hC...u.sCusTsss.t.C.......sssGQNshDhha.hWhs.C..........hssYssCl..usssYthYSu...CG...C.sshs.ushtD....hhts.Chsa	FKMTSKVNTKLQSQIQSKFQSKNKLASTFQTSSpLKstC..Dshpp..lTGC.sTN.ssC.hpu.sCSuTGsDp-hC.......ssVGQNllDhhFtpWus.C..........aNDYssClpaAspsYshYSusEhCGC.sshp.usapD....hh-uhCss.h	0	0	0	0
+5671	PF05843	Suf		Suppressor of forked protein (Suf)	Moxon SJ	anon	Pfam-B_8911 (release 8.0)	Family	This family consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster Suppressor of forked [Su(f)] protein shares homology with the yeast RNA14 protein and the 77-kDa subunit of human cleavage stimulation factor, which are proteins involved in mRNA 3' end formation. This suggests a role for Su(f) in mRNA 3' end formation in Drosophila. The su(f) gene produces three transcripts; two of them are polyadenylated at the end of the transcription unit, and one is a truncated transcript, polyadenylated in intron 4. It is thought that su(f) plays a role in the regulation of poly(A) site utilisation and an important role of the GU-rich sequence for this regulation to occur [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.91	0.70	-4.67	30	583	2012-10-11 20:01:00	2003-04-07 12:59:11	9	42	284	15	447	699	16	211.40	22	22.92	CHANGED	ohsalthM+shRRspG.......lpuuRplFpcAR.ccsclTaclYlAsALlEaassKDhshAtKIFElGhKhFss-spallcYL-aLIplNDssNsRsLFEpslsp..lssp....................................s+tlap+ahcYESpaG.-LsslhpLEcRhtphFP-.........-splphFscRYph.shsshpsp-ltt.tpphtsp.hh.............................................................spss.+Rslpp.s.p..................................................ststssss.sptt.pssstP............................lPpsIshLLshLPsspha..sus....hhssccLlcllp.psslP	..........................................................................................................................................................................................t...................t.R...hhtps...h...........................p.....pl..hh..t.h..Ahh.....Eahht...pc.....p............AhplFEh..uL....+..p.....asc...p...s....c...h..hh.tYl.-....a.l...h...c.h..s...-.....t.....s..p.................s..R...slF.ERs.l.sp....lsscp.........................................................................p.lap+alpaE....pph....G...cht....slh....p..l..c.p...Rhh..p..h..h.p..................................t..h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	173	257	377
+5672	PF05844	YopD		YopD protein	Moxon SJ	anon	Pfam-B_8937 (release 8.0)	Family	This family consists of several bacterial YopD like proteins. Virulent Yersinia species harbour a common plasmid that encodes essential virulence determinants (Yersinia outer proteins [Yops]), which are regulated by the extracellular stimuli Ca2+ and temperature. YopD is thought to be a possible transmembrane protein and contains an amphipathic alpha-helix in its carboxy terminus [1].  	25.00	25.00	27.20	27.20	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.89	0.70	-5.38	8	87	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	76	1	11	45	2	279.90	45	93.75	CHANGED	MIsSDYsNusopsuslTEshsspsptsRossTsHEAAu.sppspuhppsslPtLs+PShshDsctVophsup.L-Soh-MMSLLFcLARpARE.Gl.QRDIENKhlIusQpAQVDEMRpGAKLMIAMAVVSGVMAusSAlhGuFShuKuuKsIKQ-KuLsuNIAGRppLIDsKh-thussGpp..sRttlG+lWpssQsu...DpsALpsLsKcF-pssu+tQlhNTVhQSlGQMuNSAVQVpQGcSQAcAKEDEVpATIuQsEKQKAEDsMSFNsNFMKDlLQLhQQYuQSQNQAWKAAFGVs	..................................................tshh......s.uup.sAhsoEsht.ps-h..+s.sTtppAtsltp..uuht+spsstL.pPppslss...shlpputu-.LsuoLolLhLLhclA+cAREhGl.QRDIENcAsIsAQKsQVsEMpsGApLMIAMAVVSGlhAusS..sVsuuhuhhKssKtlKQEps.LNsNIsGRcpLIDsKhpthustupp.ssRcplG+lW....pspQss...DpstLthhs+cFchpsupspshNushQ...slGQMANSA..lQVcQGhSQAcsKEcEVpAoIAtspKQKAE-sMsasssFMKDVLpLhpQYspScspAh+AAhGVV............................	0	2	4	6
+5673	PF05845	PhnH		Bacterial phosphonate metabolism protein (PhnH)	Moxon SJ	anon	Pfam-B_9057 (release 8.0)	Family	This family consists of several bacterial PhnH sequences which are known to be involved in phosphonate metabolism [1,2].	25.00	25.00	31.70	31.70	19.20	18.40	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.18	0.71	-4.83	73	670	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	649	1	125	414	89	188.20	48	96.50	CHANGED	LtsGFs..........-sVtcuQ....psFRullcAhA+PGpltpl..........t...ss...Pssls.sAsuulhLTLhDt-TPl.......WLsss.hssssltsaLpFHsGuPlsspsppAsFAlhssspshs....sLspashGos-YPDcSsTLllplsuL.........ssG...........................slpLpGPGI..csptpluhs.LPsshhsth...............ptspsh..FPhGlDllLssGs.plhuLPRTT+lcs	................psuFh.PVpDAQ+oFRpLLKAMSEPGlIVsL.............................pphp.pu.......hpPLs.hAosuVLLTLsDsDTPV.......WLuss.ls.s-hVspsLRFHTsAPLVspPcpAsFAls....--uhust...........pLsuhusGTshsPEtuATLIlQVs.SL.........uGGc....................................hLRLoGsGI..t-cRhIAPp.LP-....shlccL...............spRsps..FPLGIDlILTCG-..+LlAlPRTT+VE....................	0	22	65	91
+5674	PF05846	Chordopox_A15		Chordopoxvirus A15 protein	Moxon SJ	anon	Pfam-B_9149 (release 8.0)	Family	This family consists of several Chordopoxvirus A15 like sequences.	21.10	21.10	25.20	24.60	18.70	18.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.05	0.72	-3.93	8	45	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	37	0	0	27	0	90.50	59	96.22	CHANGED	MFVDDsTlIlYs+...WPoCLlssss+alsFPssN..ShTFcsh.hKIsp.shpSVLLlNPShlcLLKICVYl+RhpWcGcIhILFEpcNKPPPFRL	.........................MFVDDNSLIIYST....WPSsLocooG+lIshPcN+..SaTFKEs.FKlD...........E.SlKSILLVNPSuIDLLKIpVYh+RIKWhGcIalLFEpENhPPPFRL..	0	0	0	0
+5675	PF05847	Baculo_LEF-3		Nucleopolyhedrovirus late expression factor 3 (LEF-3)	Moxon SJ, Mistry J, Carstens EB	anon	Pfam-B_9292 (release 8.0)	Family	This family consists of LEF-3 Nucleopolyhedrovirus late expression factor 3 (LEF-3) sequences which are known to be ssDNA-binding proteins [1].  Alkaline nuclease (AN) and LEF-3 may participate in homologous recombination of the baculovirus genome in a manner similar to that of exonuclease (Redalpha) and DNA-binding protein (Redbeta) of the Red-mediated homologous recombination system of bacteriophage lambda [2].\	      LEF-3 is essential for transporting the putative baculovirus helicase protein P143 into the nucleus where they function together during viral DNA replication [3]. LEF-3 and other proteins have been shown to bind to closely linked sites on viral chromatin in vivo, suggesting that they may form part of the baculovirus replisome [3].	25.00	25.00	44.40	74.10	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.20	0.70	-5.54	19	45	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	42	0	0	46	0	347.40	34	89.27	CHANGED	pcctssss.uupsu..phKcshKpVsG.cLlsKshlSlsNchaY..hF+FLlDNpscsYYGstppFpsLh.spsYclsLsa.cp......+l.Isca.cpspsh-psls.VKp..hLptpDF-s--hVsVlAKL+hGFKhlss.ssYKhVFplNhtcstsssp...lhQVEChANhKplusshKs..pshpsts-LhcaahcspsphFsLhRVKC.Qposts...FhNashpshTplEhs.ppsspsh.s.sp.sphs.NISRuNK+lhptpls.phpsEp....pupc+FolpaphtDp.......schhKusaYlcspssppts...ppt...................splpKLphDlsQLsshlpcslhcshIYVssDssss...shNlL.GLTKaDhDs.ppYpsl	.................t..ph.stss.s.sssp..ph+cphKpVsG.pLlsKshhSINNEsaY..hF+FLl-NtscsYYGssppFpshc.spsY-lsLsYscp......+lhIsca.cpspsh-phls.l+c..hlptp-F-s--sVoVlAKhKaGFKhlsu.shYKhVF.lshtss.tssss...ssQVEChuNhK+lssshKs..cslpsps-LhcahhcspsphFsLaRlKCQposss....aKNasltshTplEhs.ppsspsh.stpp.sshs.NISRuNK+lhptpls.plpsEp....pus-RFslpaphp-p..............schlKusaYlcsppspptp....ps...................splpKLpsDlNQLssLIpssll+VhIYVssDssss...NhNVL.GLTKa-lDs.spYpsl.......	0	0	0	0
+5676	PF05848	CtsR		Firmicute transcriptional repressor of class III stress genes (CtsR)	Moxon SJ	anon	Pfam-B_9312 (release 8.0)	Family	This family consists of several Firmicute transcriptional repressor of class III stress genes (CtsR) proteins. CtsR of L. monocytogenes negatively regulates the clpC, clpP and clpE genes belonging to the CtsR regulon [1].	21.90	21.90	22.20	26.70	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.87	0.71	-4.25	48	1181	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	1166	2	147	497	0	148.80	48	97.41	CHANGED	Mp.NlSDlIEpYlKplLppop...hlEI+RuElAspFpCVPSQINYVIsTRFThc+GYlVESKRGGGGYIRIhKlphscpt.pllpplhptI.GssIoppsApslIppLhE-plIocREupLhhuslscpsLs.hthstcsplRAclL+uhLppLph	.....+NhSDlIEpYIKplL-pS.s.........hlEIpRuplAspFpCVPSQINYVIpTRFT.p+GYlVESKRGGGGYIRIsK..lchp-.p.p...ph....lppl...l...p..hI.G.p......p.lSQ.ptupslIptLl-cplITcREupLlhus.ls......c......c.....sLu...........pcshlRAplL+plLpplp.h......................................................................................	0	60	102	126
+5677	PF05849	L-fibroin		Fibroin light chain (L-fibroin)	Moxon SJ	anon	Pfam-B_9321 (release 8.0)	Family	This family consists of several moth fibroin light chain (L-fibroin) proteins. Fibroin of the silkworm, Bombyx mori, is secreted into the lumen of posterior silk gland (PSG) from the surrounding PSG cells as a molecular complex consisting of a heavy (H)-chain of approximately 350 kDa, a light (L)-chain of 25 kDa and a P25 of about 27 kDa. The H- and L-chains are disulfide-linked but P25 is associated with the H-L complex by non-covalent force [1].	25.00	25.00	46.80	45.70	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.45	0.70	-5.03	5	31	2009-09-10 22:28:38	2003-04-07 12:59:11	6	1	12	0	2	33	0	225.20	41	90.96	CHANGED	PSVTIsQYS-NEIPPclDNGK..SSulI-RAFDlV.DGGDsNIYILNlQQILNDhAsQGDutSQApAVAQTlAIlu-LSuGIPGDACAAAsVlNAYosuVRSGNsuuhRpALus..aIp+luoNlsLIsQLspN............PsSlRYSsGPuGsCuGGGRSYsFEAAWDuVLusucsh.SSLlNEEYClAKRLYNAFNlRSNNlGAAITAsulssVspVspplhuolsslLRulANGGNAsGAAAsApstLsNAA	..................p-ls.ph-.Gp..spsllspAaplV.Dsu-hsIahLslpphlhD.hAsQsD.ssSQuhAluQThGIluELouslsGDuCutupllsSYsshhp.oG.NpAs..hppAlss..YssplspslstlshLhpN............PstlR.psus.st..uCuGG.GRuYsaEtsWD.hLusus.....t.sLlNEphChu+RLYsuhstRSNsluAAhsAussssspQlhctshspIsshLpssssGssssshstshpptlspu.....................................	0	1	2	2
+5679	PF05851	Lentivirus_VIF		Lentivirus virion infectivity factor (VIF)	Moxon SJ	anon	Pfam-B_9439 (release 8.0)	Family	This family consists of several feline specific Lentivirus virion infectivity factor (VIF) proteins. VIF is essential for productive FIV infection of host target cells in vitro [1].	25.00	25.00	210.60	210.30	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.77	0.70	-5.69	4	25	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	5	0	0	26	0	235.20	54	97.13	CHANGED	huDEDWQVSRpLFsVLQGGl+sAMLYIosl.schEpt+hK+shKKRLtchEstFIhpLR+AEGI+WSFHTRDYHlGaV+EhVAGoo.PsuLRLYVYISNPLWHppYRPsL.saNpEWPaVNhWIpstFMWDDIEsQpIhpuscsu.GWsPGMlGlVIKAFSCsE+Kh-hTPs.lIRGEIDPpcaCGDCWNLhClRNSPPsoLQRLAMLApG+.scSW+GCCNpRFlSPaRTPsDL.VlQspssaphLaphcL	.........................................M.Ylpc...ppppEpphKpFKc+LuhpEh+WIR+LRhsEGILWSFHTREWHsshV+ELVAGTG...sLKLYCYISpPlW+.RYRPTl.cWNppWPYuNlWlT-tFMW-.IppppIhhsGcVostaPPGaIuLllKAYoCpp+K+DlThtcIIhG-hc.pKWCuDCWsLIllRNTPPhTLQRLAhLALGRKlhsWhCKssaRFhpsRhTPLDpcIl.sssspEsLWh...h........	0	0	0	0
+5680	PF05852	DUF848		Gammaherpesvirus protein of unknown function (DUF848)	Moxon SJ	anon	Pfam-B_9475 (release 8.0)	Family	This family consists of several uncharacterised proteins from the Gammaherpesvirinae.	24.30	24.30	25.10	28.60	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.81	0.71	-4.35	13	27	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	22	0	0	24	0	140.60	32	96.32	CHANGED	pssspK-hltpsLEuslNK+suVSlhDRFGpssuLFcpQappTpcul+stpph+cppclcshlsslcspIpp+p+ElutLpp.hsh+KlschEcLsD+lpEL+--lchEL-slpt......supp-shsupssplc-sIhpWRLEsLPcVPs	.....ssspK-hltpsLEuslNK+suVSlhDRFGtssslFptQappspcul+shpph+cpppltshlsslcpplpppppElshLpt.hsh++lpchEtLp-clt-L+--lphcl-tlp.......ttpp-shssppsp.c-sIhpWRL-pLPpVs...	0	0	0	0
+5681	PF05853	DUF849		Prokaryotic protein of unknown function (DUF849)	Moxon SJ	anon	Pfam-B_9059 (release 8.0)	Family	This family consists of several hypothetical prokaryotic proteins with no known function.	23.20	23.20	23.30	23.20	22.90	23.10	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.60	0.70	-5.51	131	1281	2012-10-02 01:07:48	2003-04-07 12:59:11	7	8	668	31	447	1226	1571	267.90	29	87.36	CHANGED	+lIITsAlTGuhpT.spsP.tlPlTPcEIAcsAlsAhcAGAullHlHsR...pscsGp...P.op-schapchlstI+pt..s-.hllslT...TGGu................sshsh...c-Rlthltth......pP.EhsoLshGohNFu...........................-hlapNo.s.lcphhpphp.ptGl+PEhEsaDsGc.lhphtphlcc.Gll.c..sPhhlphVh..Glh....uGh.sucscslh...hhhpphsc......shp.W.........oshuhG.+pQhPhsshuhhhGGpV.RVGLEDslahs+GpLA..oNAphVc+ssplscphGtclATPsEARphLuL	..................................................................................................................llITsAlsGuhto.spsP.tlPlTPcElupsAhpuhcAGAullHlH..sR.......sp.s.Gp.................s.ot-sshapchlptI+pt....s....s-.hl.lp.lo...oGuu.......................sths.......ppRh.thlpth........tP-hsoLshGohNas...........................shla.ss.s.lcphhpthp.pt.Gl+sEhEhaDhup..lht.h.tp.h.............hcc..Gll..p.....s..P.h.h.hphlh.......Gl..........sGh..sssspslh......h.h.h..pphsp.............sst.W......................................sshuhG..+pp..h..s..h..sshuhhhGG.p.l.RVGLEDslah...s...c.....G.p....hA.....oNuphVccshplhcth.utplAo.stEARphLtl.................................................................	0	95	238	346
+5682	PF05854	MC1		Non-histone chromosomal protein MC1	Moxon SJ	anon	Pfam-B_9146 (release 8.0)	Family	This family consists of archaeal chromosomal protein MC1 sequences which protect DNA against thermal denaturation [1]. 	20.50	20.50	21.00	20.90	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.16	0.72	-4.02	5	61	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	47	2	35	62	51	93.70	51	83.19	CHANGED	ssKRNFALRDcDGNEhGVFSGKQPRQAALKAANR....Gco-.cAs.s.IRLRERGTKKVHIFcGW+hcVcAPcs+PsWMPscIoKPNVKKpGIEKLE	...........t.sKRNFsLR-pcGpE..huVFoGppPRQAALKAApR........Gpss..tt..t....IRLRE..+GT.cKVHlacGWthp.sAPc..sp.P.s..WMP..s.......cI...sKspVpKpGlE+l-.........................	0	6	26	33
+5684	PF05856	ARPC4		ARP2/3 complex 20 kDa subunit (ARPC4)	Moxon SJ	anon	Pfam-B_9272 (release 8.0)	Family	This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion [1].	22.20	22.20	23.80	23.30	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.93	0.71	-4.87	21	366	2009-01-15 18:05:59	2003-04-07 12:59:11	7	5	294	15	220	305	4	158.30	66	89.93	CHANGED	MusslpPYLsAVRpTLpAALCLpsFsSplVERHNKPEVEl........s.........sS..tEL........lLsPlhluRs-pE..+sLIEsSlNSlRlSltlKpu....DEl-cILs+KFs+FhtpRA-s...FhILRRKPlp...............GYDISFLITNh................HoEpMh+pKLVDFIIpFhp-lDKEIS-hKLslNuRARhsAcpaLppF	......................................MotoLRPYLssVRsoLpAALCL...........pNFuSQs..VERH....N+PEVEl........p...................oS...EL........LLpPlhIuRNE..........pE............+VLIEsSINSVRlSItlKQA....DEIE+ILsHKFhRFhh.RAEs...FhILRRKPlc...............GYDISFLITNa................HTEpMhKHKLVDFlIpFME..ElDKEISEMKL.lNARARhVAEpFLp..........................	0	72	122	181
+5685	PF05857	TraX		TraX protein	Moxon SJ	anon	Pfam-B_9375 (release 8.0)	Family	This family consists of several bacterial TraX proteins. TraX is responsible for the amino-terminal acetylation of F-pilin subunits [1,2].	22.10	22.10	22.10	22.50	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.72	0.70	-4.70	27	1213	2012-10-02 17:00:17	2003-04-07 12:59:11	6	5	883	0	132	947	36	217.00	23	91.75	CHANGED	sst-hLKhlAllhMlhDHls...hlhhsshsh................hhh......lGRlAFPlFshllAhNht+.......stsht+hhtRLhhFullupssahhhss...........shhshNllFThhlshhslhhlcptphhthh....................hhhslhhhlshhshs-YshsG.......................lhhslshahhhpp..........................s.hhshslhhhshshhh...........tphhAhhslsllslh...........ststhph.hh+hhFYhaYPsHLhlLhllth	..................................................h..tthlKhlAhl.hMllDHls.....hh....h....h..p.......h...............................hth......................lGRhuhPlFsahhs..sh.+.......T+sppcahhRLhhaul...ls...phs...h.hlhsh..............................s..h.h.t..tNlh.h.o....l..hluhhhlh.h....h....c....t...hp...t...h..tth.........................................hh.hhlhh.hh......h..h....h.s.....sau..hs.u..........................................ll.h...h...hlh...ahhhcp.....................................h..phh...h.hs.s....hhhhhh.shshh............................................stth.h.h.hh.sh.sh.lhhh......................t.tp.u.hp.t.h.h..+.hhFYhFYPsHLhllsllt.h.............................................	1	41	72	102
+5686	PF05858	BIV_Env		Bovine immunodeficiency virus surface protein (SU)	Moxon SJ, Bateman A	anon	Pfam-B_9413 (release 8.0)	Family	The bovine lentivirus also known as the bovine immunodeficiency-like virus (BIV) has conserved and hypervariable regions in the surface envelope gene [1]. This family corresponds to the SU surface protein.	19.90	19.90	20.80	27.80	19.20	19.80	hmmbuild  -o /dev/null HMM SEED	548	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.94	0.70	-6.55	4	54	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	9	0	0	73	0	176.00	30	83.22	CHANGED	MDQDLDRsERGEtcGcS-EhR.LlQE-lDcGRLTs+EALpsWh..NNGEIHPWVLsGMhShGVGML..hGVYCplPssllWlLlhQLCIYhulGETSRcLDssSWpWVRuVhIluILGTLoMAGTsLA-ss.u.................ol..NIT..shp...DT-.....Ph......hLhhLhLssILGlLGlIlshRRSNstsILuARDslDWWLSANpEIP.KFshPIILISSPLAGhhGaaVMc+a.chhctGCQhCGSlS.MWGMLL.EIGRhLs+REWsVSRlhVILhISFSWGMahs+..VpAptpHlAMVTSPPGYRIVNDTScAPWFCFSsAPIPoCpSSpWGsKYapEKlNpTlVcQlhcptEtHoRAoWIE.PDLFEEVlYELALLSANuS...........hQV+ssNsTDlCsopNSopssspTM...ThLcLRtplSsTWlsNSSLQFsVHWPaVLlGhNsSp.ostsaNsssWIATNCMDPIpLNcSp.........c-L.KNa.sRsloCVsu..shophs.tpsTLCGaNTsCLpFGp+uhSTNSLlLCQ+Nsh......sNcpFaSLSHSFSKQASt+WILVKVPSYGFVVVNDTtsP	.................................................................huhulGhl..hGlhh.lstshhhhLh.pl.slhhuhGEssRpl.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+5687	PF05859	Mis12		Mis12 protein	Wood V	anon	Wood V	Family	Kinetochores are the chromosomal sites for spindle interaction and play a vital role in chromosome segregation. Fission yeast kinetochore protein Mis12, is required for correct spindle morphogenesis, determining metaphase spindle length [1]. Thirty-five to sixty percent extension of metaphase spindle length takes place in Mis12 mutants [1]. It has been shown that Mis12  genetically interacts with Mal2, another inner centromere core  complex protein in S. pombe [3].	25.00	25.00	25.20	26.80	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.85	0.71	-4.38	18	240	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	205	0	163	219	0	146.10	27	49.73	CHANGED	hlT-ahGasPhohls-lINAls-hhacshsAhEpslhc+hph.....................Gschhs.........pEIcpGotKlcsLLcsplDctF-KhElalLRslhslP.stLL.cshh+.ht+psphphpp........ppptcs-hphcpt.hp-LEpphplptpLccp	.............................................h.scahuasP......ohls-llNuls-h.lac.shsulEpsLhpp.st.........................................ssp.hs...............-IcpGs.pplcsllcsplD+tF-+aEhasLRslhsl......P...stL.....l....t.shh+.hpphp.phshpt.............................ppptch-.phpph...hpcLppptphpt.Lpp............................................................	0	45	83	128
+5688	PF05860	Haemagg_act		haemagglutination activity domain	Yeats C	anon	Yeats C	Domain	This domain is suggested to be a carbohydrate- dependent haemagglutination activity site ([1]). It is found in a range of haemagglutinins and  haemolysins.	19.60	19.60	19.90	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.44	0.71	-4.36	57	2008	2012-10-02 14:50:22	2003-04-07 12:59:11	8	357	848	3	480	2049	208	124.30	28	7.14	CHANGED	spsssssspsssst....sssshslsshshsssuuhshpsappFsls......psuslh.s..p....................sssspsIlNcV..susssSpIpGhlc.s.t......spAslhlhNPNGIhhsusuplNsushhlsTsssshpts	...................................ss..............ht.......sss.sh..s...hls....Ish.s......ss.u.u.huhspa.p.pFsVs..........ppu...slh...N...p.............................sssupsILNcV......s..u....s..............s...sSp..lpGhlc.lhG.......tpA..pVhlsNP.....sGIsh.susuh.l.N.s.sphsloTupspht..s.........................	0	60	245	377
+5689	PF05861	PhnI		Bacterial phosphonate metabolism protein (PhnI)	Moxon SJ	anon	Pfam-B_9004 (release 8.0)	Family	This family consists of several Proteobacterial phosphonate metabolism protein (PhnI) sequences. Bacteria that use phosphonates as a phosphorus source must be able to break the stable carbon-phosphorus bond. In Escherichia coli phosphonates are broken down by a C-P lyase that has a broad substrate specificity. The genes for phosphonate uptake and degradation in E. coli are organised in an operon of 14 genes, named phnC to phnP. Three gene products (PhnC, PhnD and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports phosphate, phosphite, and certain phosphate esters such as phosphoserine; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) probably comprise a membrane-associated C-P lyase enzyme complex [1].	22.70	22.70	22.90	52.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.10	0.70	-5.93	46	678	2009-01-15 18:05:59	2003-04-07 12:59:11	7	3	652	0	125	469	126	346.70	67	97.64	CHANGED	MYVAVKGGEcAIpsAapLLsppRRGD....suhspLolsQIppQLsLuVsRVMoEGSLYD.-LAALAlKQApGDhlEAlFLLRAYRTTLPRhuhotPl-TusMtlcRRISAsFKDlPGGQlLGPTaDYTHRLLDFsLhuE...........................................stsPps..................................tscshscs...hP...+Vh-hLppEGLlpsp.........................s....sss.....p.ssDlTREPLsFPssRutRLQsLARGDEGFLLALuYSTQRGYG.cs..HPFsGElRhGpVsVplss.EL.......GFslplG-lplTECp.hVNtFpGsts.....psPpFTRGYGLsFGpsERKAhuMALlDRAL...pstEhsEss..uPAQDpEFVLuHsDNV-AsGFVpHLKLPHYVDFQuEL-LlR+hRpctspt	...........................MYVAVKGGEKAI-AAHtL.-scRRGD....sslPELSVuQIcQQLsLAVDRVMTEGulhDRELAALAlKQAuGD.VEAIFLLRAYRTTLs+lusScPlDTspMRLERRISAsYKDIPGGQLLGPTYDYTHRLLD.FoLLAs.........................GEsPshs..............................................................ss-uptpssP+VhuLLu+pGLhchE..............................p...DsG.......upPsDITRpP.saP....s....oRouRLQpLhRGDEGaLLALAYSTQRGYG.RN..H.PFAGEIRsGhl-VpI....sPEEL.......GFAVslGElhhTECE...M.VNtF.lssss.............EPP+FTRGYGLVFGhSERKAMA..MALVDRAL...pAsEaGEcs..s.uPAQDEEFVLuHuDNVEAuGFVSHLKLPHYVDFQAELELL+RLppEps.pu................	0	22	66	91
+5690	PF05862	IceA2		Helicobacter pylori IceA2 protein	Moxon SJ	anon	Pfam-B_9436 (release 8.0)	Family	This family consists of several Helicobacter pylori specific IceA2 proteins. The function of this family is unknown.	25.00	25.00	57.10	26.30	23.20	16.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.85	0.72	-4.26	2	35	2009-01-15 18:05:59	2003-04-07 12:59:11	6	2	20	0	0	32	0	51.90	64	104.66	CHANGED	MAlVlKVVNGKIQEaENG.aKRTYsSNhlsspssGtlVAssTuKGKVEc.........h	......MAlVlKVVNGKIQEYENGsaKRTY.GSNsVsVpluGuIVAssTuKGKVEEYcNG...............	0	0	0	0
+5692	PF05864	Chordopox_RPO7		Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)	Moxon SJ	anon	Pfam-B_9596 (release 8.0)	Family	This family consists of several Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide sequences. DNA-dependent RNA polymerase catalyses the transcription of DNA into RNA.	25.60	25.60	25.70	107.00	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.22	0.72	-3.88	7	45	2009-01-15 18:05:59	2003-04-07 12:59:11	7	1	40	0	0	20	0	63.00	78	99.96	CHANGED	MVF.LVCSTCGRDLSEtRY+LlIcctpLKcVLtslpp.CCRLKLSTQIEP.RNLTVpPhLDIN	MVFQLVCSTCG+DIScERY+LII++coLKcVLsoVKNpCCRLKLSTQIEPQRNLTVQPLLDIN...	0	0	0	0
+5693	PF05865	Cypo_polyhedrin		Cypovirus polyhedrin protein	Moxon SJ	anon	Pfam-B_9652 (release 8.0)	Family	This family consists of several Cypovirus polyhedrin protein. Polyhedrin is known to form a crystalline matrix (polyhedra) in infected insect cells [1].	25.00	25.00	499.30	499.10	21.50	17.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.58	0.70	-5.16	2	14	2009-09-11 12:22:05	2003-04-07 12:59:11	6	1	4	3	0	17	0	247.00	95	99.77	CHANGED	MADVAGTSNRDFRGREQRLFNSEQYNYNNSLNGEVSVWVYAYYSDGSVLVINKNSQYKVGISETFKALKEYREGQ+NDSYDEYEVNQSIYYPNGGDA+KFHSNAKPRAIQIIFSPSVNVRTIKMAKGNuVSVPD-YLQRSHPWEATGIKYRKIKRDGEIVGYSHYFELPHEYNSISLAVSGVHKNPSSYNVGSAHNVMDVFQSCD.AL+FCNRYWAELELVNHYISPNAYPYLDINNHSYGVALSN+Q	MADVAGTSNRDFRGREQRLFNSEQYNYNNSLNGEVSVWVYAYYSDGSVLVINKNSQYKVGISETFKALKEYREGQ+NDSYDEYEVNQSIYYPNGGDA+KFHSNAKPRAIQIIFSPSVNVRTIKMAKGNuVSVPD-YLQRSHPWEATGIKYRKIKRDGEIVGYSHYFELPHEYNSISLAVSGVHKNPSSYNVGSAHNVMDVFQSCDLALRFCNRYWAELELVNHYISPNAYPYLDINNHSYGVALSN+Q	0	0	0	0
+5694	PF05866	RusA		Endodeoxyribonuclease RusA	Moxon SJ	anon	Pfam-B_8996 (release 8.0)	Family	This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC [1,2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.94	0.71	-3.70	96	2230	2009-01-15 18:05:59	2003-04-07 12:59:11	6	7	1256	7	191	1349	208	112.50	30	86.93	CHANGED	ls.h..........P..psptp.......R.hs.......sthh.s.pcsppa+..ptlthhhtpthhth....h..p...........h..lplphhh.hscph....h...........................DlDNh...hKslhDuls..........th................lapDDsQ..lschpsp.phhspp.....s+ltlplppl	.............................................................sh.sP...sssshh........R.hp..........tsphahs.ptspca.+.p.t.l.t.h...hlppphh...chs.....h..................................lplc.hhh...sscph........p.................................................DLDNl....hKAshDALs...................+u.........ulhh.DDpQ.....lschp.l..h...ht.....hs.s................s+ltlpIpc..........................................	0	62	115	159
+5695	PF05867	DUF851		Protein of unknown function (DUF851)	Moxon SJ, Coggill P	anon	Pfam-B_9669 (release 8.0), Jackhmmer:Q9N4S5	Family	\N	25.00	25.00	25.50	25.50	21.80	21.20	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.63	0.70	-5.13	7	28	2009-01-15 18:05:59	2003-04-07 12:59:11	6	4	8	0	28	23	0	198.80	29	48.97	CHANGED	splscspNlEVpsR-VD-sphERVhcKapcEK+pssphsts...lDEKSKlLMDRV.sKKPa.hK..pp-pG.hLhDE.SoFYppsss..KK+.csSh...-DoYsphPKLtDVpKhsspNVascp...GVPFWAVplEPsEEDhpss-.sIoVGoEHlEhY+sKplsLpTI.sTKLhLsElQPLs-LhKRD-lHFsPcLVFSNTlRSLlpspth-....tc.+p...........psKs--ptcst...+lpF-ppcscpa.hYpRsN	...........................pspplplpppplDptphc+lhcKhpppKtp.........s.........lD-Ks+lLhDRl.sKKPa..K.....ppppt.hh..h.D-.o..sFac.p...........pKh.............ptp....-DsYs.hPKLtsVhKhst.psla.pts....s.V.PFWAh..hhc.PsEEDh..............ps.s.-.ssIsVso-HlEhapp+clsLpo.h..ppp.lhhs.atPhs.LhcRDchaFpscllFSNTlRohlpht................p............pt...cptt......plph........h..Y..............................	0	11	15	28
+5696	PF05868	Rotavirus_VP7		Rotavirus major outer capsid protein VP7	Moxon SJ	anon	Pfam-B_9690 (release 8.0)	Family	This family consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer protein layer [1].	24.00	24.00	24.10	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.83	0.70	-5.21	3	112	2012-10-01 19:08:57	2003-04-07 12:59:11	6	1	9	0	0	90	0	217.90	65	99.92	CHANGED	MshLLLLVlAAsAsAQLsIlPpocPEICVLaADDathDsNpFsGNFTNIF+oYNSVTLSFaoYcSosYDVIDIISKcDhSSCsILAIDVscuoMDFNTFLQSsNECoKYAAsKlHYlKLPRsEEWFuYSKNLSFCPLSDSLIGlYCDTQLssTYFslScuusYDVTDIPEFTEMGYVFHSND-FYIC+RIS-csWlNYHLFYR-YusSGTVS+pVNWGNVWSGFKTFAQVVYKILDIFFNsKRNlEPRA	...............................lhP.spPElClLaA.sDh..ps..spastNFTpIFcSYNsVTlShhsYsSsNYDV..IDI..LS+hDa..StCp...ILAIDVhcPpM.DFl...oFLQSsNpCSKYuupKIHY.KLsps-EWFVY..SKNLKFCPLSDsLIGhYCDTQlssTYFsLSss.p+.Y-VTDlPEFTphGYsFaS.s.-sFYlC+RloEctWlNhHhFY..R..c.ssSGsluptIsWsNVWoshpTFAQhlYKILDlFFN.spRshEPRA............................	0	0	0	0
+5697	PF05869	Dam		DNA N-6-adenine-methyltransferase (Dam)	Moxon SJ	anon	Pfam-B_9691 (release 8.0)	Family	This family consists of several bacterial and phage DNA N-6-adenine-methyltransferase (Dam) like sequences [1].	27.10	27.10	27.20	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.41	0.71	-4.84	17	691	2009-01-15 18:05:59	2003-04-07 12:59:11	6	13	478	0	57	456	132	166.20	39	83.69	CHANGED	.ptopp.cpstDpWpTPptlFhulsuhFG.....asLDssusccNAhCspaaTtE-NuLppDWspc......Gsh.FhNPPYS+............hp.alc+Ah-ppt+usphVhhlhsusspsh..Wacc....ADcltaIp...............GRluF..s...sstptpstssp...uuslhIac.h..htstthohls+ppLhtpGp.hht.h.tt	....................................s...upp.tc.spDpWpTP..lFtulsh.FG.....FhLDss..u...s....s.c...N...A....h.C..s..t..ahT........t......p...D.......sA......Lsp-.Wsp.+........................GAl.asNPPYSp.................................hc.alc+A..uptp..pt...t.....p..h.Vhh.lhsts.....sV.h..Whpc.h..h.............sDc...lt.h.Ip........................G.RIsF..P.....hsh-.Kpssot.....uuhlhlac.h....t.hhohls+stL.shGt.........t..........................................	0	14	31	43
+5698	PF05870	PA_decarbox		Phenolic acid decarboxylase (PAD)	Moxon SJ	anon	Pfam-B_9737 (release 8.0)	Family	This family consists of several bacterial phenolic acid decarboxylase proteins. Phenolic acids, also called substituted cinnamic acids, are important lignin-related aromatic acids and natural constituents of plant cell walls. These acids (particularly ferulic, p-coumaric, and caffeic acids) bind the complex lignin polymer to the hemicellulose and cellulose in plants. The Phenolic acid decarboxylase (PAD) gene (pad) is transcriptionally regulated by p-coumaric, ferulic, or caffeic acid; these three acids are the three substrates of PAD [1].	24.60	24.60	24.80	29.40	23.80	24.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.05	0.71	-4.76	8	316	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	298	19	83	233	0	152.10	50	91.04	CHANGED	LssFlGKHFIYTYDNGWcYElYlKN-+TIDYRIHSGhVGGRWVKDQcVaIV+LuculYKlSWTEPTGTDVSLshs.s-++lHGsIFFP+WVt-cPE+TVCFQNDHIsLMcpYREtGPTYPphVVsEFAoITalcDsG.sN-sVIAsAP.u-Ls--assshp	......................LpsFlGpHhIYTY....D........NG....WcYEhYlKN-pTlDYRIHuGhVuGRWV.KDQpspIVpl.s.culYKloWTEPTGTsVuLsh..s-+hlHGsIFFP..+..Wlh...-cPEhTVCaQN..-HlslMct.R-th.sYPphVlsEFAsITahtcsGhsN-pVIspsP.sthspDh.ts.h...............................................	0	16	40	61
+5699	PF05871	ESCRT-II	DUF852; 	ESCRT-II complex subunit	Moxon SJ, Wood V, Mistry J	anon	Pfam-B_9765 (release 8.0)	Family	This family of conserved eukaryotic proteins are subunits of the endosome associated complex ESCRT-II which recruits transport machinery for protein sorting at the multivesicular body (MVB) [1].  This protein complex transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [1].	21.00	21.00	22.60	22.40	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.63	0.71	-4.25	25	310	2009-01-15 18:05:59	2003-04-07 12:59:11	7	9	278	16	218	304	1	140.00	35	58.95	CHANGED	.hYsFPPFFTlQPNssTRppQLssWssLlLsYC+ap+lapLs....l.......h-s...s.............s.sLFpNps..IpR........+Lu.ptlchllsplhcp....u...pAEal..s............ps+o.....................phhIhWRps-EWusllhpWlpcsGppsoVhTlYELspGDpTp.spEFHsL-ps	.................YsFPPFFT......l..........QPs...h.....sTRppQlptWss.......LlLs.Ys....+.pp+hapls.........l.......-t......p......................................s.sLFpNpp....IpR............+Ls.-shphllctltcp.........G...........psEal...c............ps+s............................................................phhIhW+p..s-EWu.sllhpWlpcsG.........ppsoVhTlYELspG.-sTt.....spEaash-..s.......................................................	1	77	121	179
+5700	PF05872	DUF853		Bacterial protein of unknown function (DUF853)	Moxon SJ	anon	Pfam-B_9798 (release 8.0)	Family	This family consists of several bacterial proteins of unknown function. Swiss:Q8YFZ2 is thought to be an ATPase.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.68	0.70	-6.15	9	1311	2012-10-05 12:31:09	2003-04-07 12:59:11	7	6	1266	0	310	1381	194	478.50	52	96.43	CHANGED	pshhssssssp.lhlthphuNRHGLIsGATGTGKTVTLQhLAEuhSsAGVPVFhADVKGDLSGlutsGpss-KlttRhtphGls.sap.pAhPVhhWDlaGc.pGHPlRsTISEMGPLLLuRLLsLNDsQpGVLNlsF+lAD-cGLLLLDLKDLpAlLpal.uDpAcphsspYGNlosASlGAIQRsLLsLEpQGAcpFFGEPALclpDlMRTc.ssGRGsIslLuA-KLhp.sP+LYuTFLLWLLSELFEpLPEVGDsDKPKLVFFFDEAHLLFsDAPKsLl-+VEQVVRLIRSKGVGVYFVTQNPhDlP-sVLuQLGNRlQHALRAaTP+-QKAVKsAAcTFRsNPsFsstpsITpLGsGEALVSsL--KGsPshVpRshlhPPtSRlGPlospERstllpsSPltGhY-pslDR-SAYEhLst.+sutuscttppshsttpt..............................psuhhGshpshthus...pst.R..ushppslsEuhsKSssRolssQluRplVRGlLGoL....+R	.......................................................................................................ts....tpsspplhLh...thANRHG..LIsGATGTGKTV.T.LQ.h....LAEuh...S.ch.G...VP.VFhAD.VKG..DL.o..GlA.p.s...G....s....s....s....-.K....l....h....t....R.hp..p.l.....Gls...-...apspA..PV...hhWDla....GE........pGHPVRAT...................l...........S..-hGPLLLuRLLsL.....N.....DsQpGVLsllF.+lAD...-......p...G.....L..........LLLD........hKDLRAll.......pal........u.......-..s..u..............+..............p........h.p.sp..YG...NlSsA......SlGAIQRuLL....sLEpQGA.s....pFF..G.E.....P.hL-l.pDhM...RTD....ss....G...+GlINlLuA..-+Lhp..tP.+LYu..sF.LLWhLS....EL.a.E.p.L.....P.....EsG.D..h-..K...PK.L..VF.FFDEAH.....L.L...F.......s......D....A......P.......p......s....L.....l.-.....+....l..E...Q....VV.RL.I...RSKGVGVaFVTQNP..tD.lP-sVLuQLGNRVQHALRAFTP+DQKAVKs..AApThRsNP.s..a.D.sppAIspLGsGEALlShL-tK.G.sPosV...-Rshlhs...PpS+hGPlotc.ERsslls.p.SPlh.G+Y-pslDR.ESAYE..hL.pp.p....h.p.ss....s.p...t.....t.p..s....s...s.s.p..t.p.t...........................................................t.ss..hh..s..s.h..p..s.h.hh.u....................s..ts+..........sttpps....l.s...p.......sh...s....K.S.s.sR............plsp........pI....l...RGlLGol........................................................................................................................	0	80	193	258
+5701	PF05873	Mt_ATP-synt_D		ATP synthase D chain, mitochondrial (ATP5H)	Moxon SJ	anon	Pfam-B_9814 (release 8.0)	Family	This family consists of several ATP synthase D chain, mitochondrial (ATP5H) proteins. Subunit d has no extensive hydrophobic sequences, and is not apparently related to any subunit described in the simpler ATP synthases in bacteria and chloroplasts [1,2]. 	21.30	21.30	21.30	21.30	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.00	0.71	-4.60	5	370	2009-01-15 18:05:59	2003-04-07 12:59:11	7	8	281	3	234	361	1	149.30	28	75.57	CHANGED	AuR+lAppoI-WuuLuEplPsNQKAphsulKohsETapoRVusLPEcPPsIDWAYYKpNVs..+uGLVDuFcKKY-ALKlPaP.......E..DKYoupVDAEcKtssKsIupacspScsRIQEYcKcLEKlKshlPaDQMThEDasEsFP-otLD.l+K.saWP........HTPEEpl	............................................Ahp...t.lDWsthsp..p..l..s..s..p..p.t..sths.........uhKp+s.-.phppcl.t.t.L.s-pPssIDauaY+sslt...psulVDchEKp...apuh.K.l.s..hs..............h..sc..httl..-u.E...pp..shpssp..phh..ptsptclpphpcpLpplcs.h.h.PF-phTh--hspshP-ht...............................................................	0	67	113	179
+5702	PF05874	PBAN		Pheromone biosynthesis activating neuropeptide (PBAN)	Moxon SJ	anon	Pfam-B_9874 (release 8.0)	Family	This family consists of several moth pheromone biosynthesis activating neuropeptide (PBAN) sequences. Female moths produce and release species specific sex pheromones to attract males for mating. Pheromone biosynthesis is hormonally regulated by the Pheromone Biosynthesis Activating Neuropeptide (PBAN) which is biosynthesised in the subesophageal ganglion (SOG) [1].  	21.50	21.50	22.40	22.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.91	0.71	-11.46	0.71	-4.95	10	47	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	27	0	11	55	0	136.30	57	89.94	CHANGED	Ma.tophlslhlllsl..sVlAosND..lKD-G.DRGAHSDRuG.LWFGPRLGKRSL+lSoEDNRQAFa+LLEAADALKYYYDQLPY.Ep.QADEPET+VTKKVIFTPKLGRShu...h--+sa-NVEFTPRLGRRLoDDMPATPuDQEhYR.DPEQIDSRT+YFSPRLGR..TMsFSPRLGRELuY-haPsKlRVARSsNKTpST	...........................................................................................................................................KKlIFTPKLGRSlu....c.p.pa-slEFTPRLGRRLu-DMPA..TPuDQ..E..hYp.DPEph-SR.T+YFSPRLGR..TM..sF..SPRLGRELuY...........................	0	5	6	11
+5703	PF05875	Ceramidase	aPHC;	Ceramidase	Moxon SJ	anon	Pfam-B_9877 (release 8.0)	Family	This family consists of several ceramidases. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates, EC:3.5.1.23.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.91	0.70	-5.26	41	599	2009-01-15 18:05:59	2003-04-07 12:59:11	7	7	310	0	390	567	261	225.10	22	87.94	CHANGED	sGaWG.sTSslDWCE-NYslS...YlAEahNTloNhlFllhuhhuhhpsh+.................pchctpa..hlshlGhhlVGlGShhFHhTLpY...................hhQLLDELsMlassslshashhsphp...................shphphhluhhlhshushlThhahh.hppPslHpsuaullsshllhhshhhhpp..l.s..................................tsc+plhphhhhulslFlhGahhW.lDphhCshhpphRpth..hPhuhhhEhHGWWHlhTGlGsYhhllhhtaLcshhpsp..ppphphha..ht.....slPtlhh	..........................ht..oS.hsa............CE.tsY.hs...hlA.EhhNT..loNhhahh.huhh..s.hh...hhp...........................pt.h.p...th....hlh.hh..h.h.h.lV.G.lGShhFHh.TLp..a...................h.hQ.h.h.DELshl.ashhhhhhh.hhshth.........................................p.p.h.hh.hhhl.hhhs...hhho.hhhhh.....p..s...hhp.p.h...s..ashhshhlhhhshhhh....th.......................................................................htt.phhth...hh...h....uhhh.....ahhuhhhW.hD..phh.Cphhpthp..h.............................hHuh.W.......Hlhhu..hu...sYhhh.hh..hhph.......t.t....h...h...................h.......................................................................................................	0	100	198	301
+5704	PF05876	Terminase_GpA		Phage terminase large subunit (GpA)	Moxon SJ	anon	Pfam-B_9892 (release 8.0)	Family	This family consists of several phage terminase large subunit proteins as well as related sequences from several bacterial species. The DNA packaging enzyme of bacteriophage lambda, terminase, is a heteromultimer composed of a small subunit, gpNu1, and a large subunit, gpA, products of the Nu1 and A genes, respectively. Terminase is involved in the site-specific binding and cutting of the DNA in the initial stages of packaging. It is now known that gpA is actively involved in late stages of packaging, including DNA translocation, and that this enzyme contains separate functional domains for its early and late packaging activities [1]. 	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.87	0.70	-6.16	53	1654	2012-10-05 12:31:09	2003-04-07 12:59:11	7	10	711	0	162	1653	633	434.80	36	87.54	CHANGED	h.lssc..u..........uupsGpW.......ctspsPYht-lh-slussp..................hccVshhpuAQlGtTp.hhhshluYhIcpsP.ushLhl.PTpstAccascs+lsPhlcsoPsLp........pplus....h.p+cssNolhpKcFs.G.GhlhhhGAsSsssL+spssRhlhhDElDta..stsl.....ssEGcPhsLAcpRspoF...sptKhlhsSTPshcs.....................sopIpptappSDpR.+aaVPCPHCGchp.....lp.app......l+a....sps..........pscsAtahC...cCushIp-ccKst...hh..tt.Gc.....Wlspss.........................................tsscpsuFalsuhYSPh...tsWsplspcalpA.......ps-spt...........LpsFhNTpLGcsW.cpc.u-..th-hppLhsRt..E.sa..............tup......VP........susl.hLTAGlDVQ.pc......RlElplhGWGpstEs.....WllD+tllh....G..............cPsstt..sattLsplLpcpat+s.sGsp.hslsshulDoGs...........................ttTpp.VYsas+pp.t...............ttpVhslKGsss..stshlppsptpsss..ttt.....ultLahVussshKsplh......spLphp...........t.ssGhlHFP.....p.....t.....hsppaacQLsAEphh..+htc.Gh..hhtWp+hp..pRNEALDshVYAhAA...thhhshp.....phcW	......................................su.t.s..a.........thhPa.h...t.hsshusp...................hctVshhtsApsGho...hl.s...hhsY..hl....pc....ts.Lhh....TpttAcpa.+p+lt.hhcs.Pt..lh.........tl..ss...............pc.psNslh.Kp.F...s.h.hhhhGh.usp.hpppshchhhhs-hs..ta.....s.h.......ptEGssh.LuppRhps...........h.lh.SoPt.hch......................sstI..phhp.pusph..+a..ahsCP..H...CGc..........ht...ats........................lph.........................p......................tspsshh.C...............psss.hlttpphp............................p..uh.........altctp.............................................................sc.hsFa.h.s.husa...poW.pllhchhps..................hts.tt..........h+shlNTshG.sa....t..sc...p.ctphl.p+h......h.....................tt.s.VP...............st.s..h..hLsAslDsQ.hp.......Rh.h.lh..Ga....u.tt....Et.....allD+..l.h..t.........................c.sp........h.hhls.t.h.h.p.+.p.a.ht..sstp..htl.thshDsG.G...........................h.sp..sYph.+ppt................hh+lh.hKGsuh..ht.....t..l..h.shsh...........ps.....p.t..................sl.L.h.ltssshKc..l.......sthhhp...................pshs.hh.h+FP...............p..............hs...hppLshEp.....+..c..Gp.................W.pp.t....ttNEAhDhhVYA.Ah...hhh.............................................................................................................................	1	49	97	131
+5706	PF05878	Phyto_Pns9_10		Phytoreovirus nonstructural protein Pns9/Pns10	Moxon SJ	anon	Pfam-B_9947 (release 8.0)	Family	This family consists of the Phytoreovirus nonstructural proteins Pns9 and Pns10. The function of this family is unknown.	20.30	20.30	20.50	20.80	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.75	0.70	-5.42	3	17	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	10	0	1	17	0	296.10	38	94.27	CHANGED	uGKLQDGVAI+RIsDAIshFsNYohG-LlssRchsluTLHslR+NlGLAWPslLhNCalHTSSHhGVMKFlLDIAhShRFGDFTLLGusGssDPFsDlclIaTKoCpsLGhsDs-FLphsDsFuYhhsSFL-cEul+usVDMplGIHNIED+YVhRhESIhcFI+tYYTtSh-DV..lsWLEKL-uAcuGlLuspKSKcQMRuElsplRscIss+IpLYINoacNSap-HaRElAcpYsslWs..losGssAcEsps-AT.....sSuSpsTusuAELs-VsctuDsNEscLp...F+Rc-DAucsAsSchsSLSG-DutpG	..............................................................................GKLQDGlAI+RIsDAIphFppYphG-L.psps.tlspL+slRtslGLAWPslLhNCalHoSSHhGVh+FllDIAhoh+hGsFTlLGusGs.DPFsDlslIaoKoChsLshsDssFLp.s-pFu.hhsuFLptpulputV-MphGlHsIED+YVhRhpsI.chlphYastS.c-l...sWl...KL--ussuhh.tpho+tQMps.ltpsRshIss..cIppYlNpppsS.p-HhRplAppYsp.Ws..lsssssut.spssss...........ssts.sss.suphssss.hsc.s-s......hptp.-ttp.hss.hss..upsu..G..............................	1	1	1	1
+5707	PF05879	RHD3		Root hair defective 3 GTP-binding protein (RHD3)	Moxon SJ	anon	Pfam-B_9973 (release 8.0)	Family	This family consists of several eukaryotic root hair defective 3 like GTP-binding proteins. It has been speculated that the RHD3 protein is a member of a novel class of GTP-binding proteins that is widespread in eukaryotes and required for regulated cell enlargement [1]. The family also contains the homologous yeast synthetic enhancement of YOP1 (SEY1) protein which is involved in membrane trafficking [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	743	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.42	0.70	-6.61	8	439	2012-10-05 12:31:09	2003-04-07 12:59:11	7	16	244	0	317	440	4	457.00	25	63.95	CHANGED	hGSQSoGKSTLLNHLFGTsFssMDA.spRpQTTKGIWlA+sssl...........cssILVMDVEGTDGRERGEDQD.FERKSALFALAsSEVlIlNMWEHQlGLYQGANMuLLKTVFEVNLpLFhpp.....ss+KoLLhFVIRD+lGsTPLENLpcoLpcDlp+IWsSluKPtuhEsoslsDFFDVpFsALsHK.hpp-pFpppVppLcpRFhpu.............hssGsFts-YH+clPADGFohYA-pIW-pIcsNKDLDLPTQQlLVApaRC-EIusEshpsFhssh....Ep..p.cEsspuuslssLGppLsslhpcslpcYDspASRYccuVYppKRppLcpKlss+lpssaQshLssL+pshl-sFcpulspulcuGp......sFucuVpsptpcslpcFccpscohsl.pssWss.cchhtKLs+DI-spsuplRstcLpcLsschE+plpspLS-sVphhhsssu..................+-sWDslhphFcppscsAlpthpsthsuF....-hs-s.pssphltsL+phSWshlcsKs+EEh..splLh+L+-RF--lFRYDsDGhPRlWpsc-DI-uIa+pARppoLpLlsVLohhRLuDss-sl.ps.hhuhpssssssusp..csl.ss.sslspsphcpltsptpILTcspppslhspFK+ps-hshs-A....KRStlsspTplPsahallLlVLGWNEFMslLRNPLahhlhhlsusssasLa.pLsLhG............PshphlpsshsplhslAcc+hcpshpsscsh+uutphcssusscspps	..................................................hGsQSoGKSTLLNtlFsspFth.st...t.......t.............psT+G..hahsh............................................................hll.hDhEGhcu...E..p.u..c.p.ps....aE+.....p...uLFsl..uh..uclhllNha.........ts.s.hpslhp..hth.h.............................h.hs...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tt................................................................................................................................................	1	98	205	280
+5708	PF05880	Fiji_64_capsid		Fijivirus 64 kDa capsid protein	Moxon SJ	anon	Pfam-B_9976 (release 8.0)	Family	This family consists of several Fijivirus 64 kDa capsid proteins.	25.00	25.00	31.60	31.50	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	561	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.66	0.70	-6.17	5	168	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	8	0	0	162	0	486.90	86	99.98	CHANGED	MsDI+LsIAPDLIHsGVPQRLSDTIILNDRPpITLLsHF-sLFcEsNIIKuP+suSspoTVNIYIKp-LL+RLHDRLuoV-ToTLPNIoQl....KEal+sFFpN-lQsIFpsLsNN-lsssFVGVTT+GLSLFAsAKsDAEQIERVQI-TLTEGNlTLKPhSADGlEVILDDsYINlVsKllGh-VpKLI-KCC+ElPAchGIlT..DEVKhhlpTGKLRlDGGYDYNCPSSoTDVT+YGsYDc.FScpMFscLspFaNlSLolVPVuALKslHlh-cELspLDuDKSLLEQsWoAlTSFlESaclKTK..............lKsDDsDchcLscLsssKsNpcusp....AolssoDKsh...........l-WYp+sF.sscT-KulsLsRsElhE.tAcsoSsllc+VKltFushhFEclsssupEKolhV...-TsuG-MTLDpYRuIu-VLNuIWKRGKDlAVcsFDYIKLGlEKA.oHLuslLhKKYNlTlDDIlNFI-KGPSYLAsLsKlsDWsLIAKlIIsSVLPsIIQuVYKoDPSsslMNSlLIo+AsNLI+sD+cRLpcKspucss.s.uNTsc+-sssKlllcKlso	.....MADIRLDIAPDLIHNGVPQRLSDTIILNNRPTITLLSHFNsLFHEpNIVKSPHlASSQTTVNLYIRKHLLTRLHDRLQTVETSTLPNITQL....KEHIpSaFcNEHQPIFQTLTNNNLSDEFLGVTTFGLSLFATSKLDAEQIERVQIETLTEGNVTLKPFSADGLEVILDDSYIGIlGKIsGLEVHKLLDKCCREVPAQMGILT..DEVKLLhRoGKLRIDGGYDFNCPAS.TTDVTHYGGYDQ.aSRQMFE+LNLFaNISLSIIPVSALKTlHlFEKELSsLDADKSLLEQTWSuVuSFlETWpVKoK..............sKs-D.DEYELTuLSsLRpshDGsS....sSSPasDKKF...........I-WY.KTF..uKhEKGSSLR+sElE-KssouTSshsKpVKIHFsVQYFDEhKsNGHEKSVsV....TpKGEMo.L-.YRKIGElLSAIWKRGKuLAsPChDYIKLGVEKA.aHLAPVIMKKYNLTIDDIIpFI-hGPSYLAKLDKIDDWSLIuKLIITSVLPNIIQAVYKTDPSNNVMNSVIISRANNLLKuDRDRLlKKAhoANsSo.SN.SspEHsQKIVLNKVTR..............................	0	0	0	0
+5709	PF05881	CNPase		2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)	Moxon SJ, Mazumder R	anon	Pfam-B_9997 (release 8.0)	Family	This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity [1]. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins [2].	25.00	25.00	25.80	30.30	17.40	17.20	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.56	0.70	-4.95	5	71	2012-10-03 21:31:48	2003-04-07 12:59:11	7	6	44	11	32	67	0	204.90	55	53.52	CHANGED	LPLYFGWFLuKR-E-sLRKTup-FLEpLGNLKAFKK+LptFsuED..K+KlDLlpYFuK.sPslLHCTTKFCDYGKAAGAEEYAQQEVVKKSYoKuFTLoISALFVTPRTsGARVELTEpQLtLWPsDADKE......L.PsDsLPRGSRAHITLGCAA-VEsVQTGIDLLEFVKLQKAG+-GEpVGELsG...GKLoYauNGMWMLuLu+KIEV+oIFSGYYGK.GssVPppGuKKGtplhppCTIl	...........................LPLYFGWFLsKcupEp.l+psu.sFLcpLsshcAFKKc.l..pp.F..ss..ts..ccclDLhpYFs+.....sPGlLHCTTKFCDYG..KAsGA-EYAQp-sVKcS.Y.uKu....FpLolSALFVTP+TsGARVc....LoEpQL....LWPsDsDK............................lsss-sLPtGSRAHlTLGCAusVEsVQTGLDLLEIlp.pKuG...pcGEpVuEl...st..........................GpLh.hGpGRWhLsLs+phclcAlFoGYYGK.tcs.Vsspuspct.t.hppCoI....................	0	8	10	14
+5711	PF05883	Baculo_RING	DUF855; 	Baculovirus U-box/Ring-like domain	Moxon SJ, Bateman A, Dlakic M	anon	Pfam-B_9633 (release 8.0)	Domain	This family consists of several Baculovirus proteins of around 130 residues in length. The function of this family is unknown, but it appears to be related to the U-box and ring finger domain by profile-profile comparison.	21.20	21.20	21.30	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.88	0.71	-4.33	25	57	2012-10-03 15:03:13	2003-04-07 12:59:11	6	1	56	0	0	68	5	133.80	38	95.21	CHANGED	MLlTlph.pD+ctala+hFpchWsp.slECtICh-cIss..cGVVslT-suslNLEKMFHspChcRW..p...ppcpRDPFNRsl+YhFsFPPco.c-spuhL-ch+.uFI...GD-ctD+hasspapR.ssspp.hlDlELDFsphL	.......................MllTlph.pD+ptaha+hFpchWs.ph.shECpICh-cIss..cGVVslo-sutLNL...EKMFHspClc...RW...p.....ppc....sRDPFNRsl+YaFsFPPcohcECpshL-ch+.sFI...GDcctDchapp.apR...lpstp.hlDlELDFpphh........................	0	0	0	0
+5712	PF05884	ZYG-11_interact	DUF856;	Interactor of ZYG-11	Moxon SJ	anon	Pfam-B_9445 (release 8.0)	Family	This family of proteins represents the protein product of the gene W03D8.9 which has been identified as an interactor of ZYG-11.  ZYG-11 is the substrate-recognition subunit for a CUL-2 based complex that regulates cell division and embryonic development [1].	25.00	25.00	25.50	41.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.88	0.70	-5.33	6	31	2009-01-15 18:05:59	2003-04-07 12:59:11	7	2	8	0	31	27	0	260.50	29	89.67	CHANGED	hPsssp-G....Psusssss....uNtG.ssstp-AuIshVh+TYupaGpDlpQhsscGlRphspslpp.ossslpphpoohppcosc.............llssLh-ho.PtpluopsIlEhFuhSSlLLllAolSSllGGYlLAPlFGIlIsslGAAIhusLVlPhhusY..LNtcsGSluupRltLllhshsQGVLhGauhsasalsupPFsslTslluSFuYPllshp.sTuRsslLGsssGsSlhhHhslGhlpGuLossYFlLouhYTluAlsLIQ..IAhRsQocss.hphYshlLVuhhlsuKshVYGlFGssc	.........................................................................t....................................................h.t-hpt..........psh+.h..shpp.sssphtphtsphp.pspp................llssl.-.hp..P.thss.slhchF.shoollLlshuluohlGuYlLuPlhslhhsthGAslluslllPshshY...Lst...............c...stuhst..p..Rh.LlhhuhsQGlLhGaulua.shls.u.pPhshlTsllhuFshslls..sp....ss.sRsslLuhssGsuhhhplshGhlpGuLoh.sYhlLosLYohuuhshlQ......l.Ah+.s.hss.s.hphYphlL.....Vs.hlhuKshsYulhGst.t.............	0	9	13	31
+5714	PF05886	Orthopox_F8		Orthopoxvirus F8 protein	Moxon SJ	anon	Pfam-B_9539 (release 8.0)	Family	This family consists of several Orthopoxvirus F8 proteins. The function of this family is unknown.	19.90	19.90	21.90	26.40	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.07	0.72	-4.14	2	53	2009-01-15 18:05:59	2003-04-07 12:59:11	6	1	30	0	0	35	0	62.00	73	96.53	CHANGED	MEGSKRKH-SRRPQQEQEQ.RPRTPPSYEEIAKYGHSFNVKRFTNtEMCLKNDYPRIISYNPPPK	..............MEGSKRKH-SRR.QQEQEQ.RPRTPPSYEEIAKYGHSFN.VKRF...T....N.-E...MCLKNDYPRIISYNPPPK...	1	0	0	0
+5715	PF05887	Trypan_PARP	Trypano_PARP; 	Procyclic acidic repetitive protein (PARP)	Moxon SJ	anon	Pfam-B_9554 (release 8.0)	Family	This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated [1].  	40.00	40.00	40.20	40.30	39.90	39.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.30	0.71	-4.37	2	71	2009-09-10 16:45:05	2003-04-07 12:59:11	6	12	35	4	18	70	31	104.10	51	41.22	CHANGED	MAPRSLYLLAlLLFSANLFAGVGFAAAA-tstspslsKGGKGK...............-.-stPE...EstPE.ps..EstPE.ps..EstPE...........EsEPEPEP..........GAATLKSVALPFAlAAAALVAAF	...................................................................................................................tPc...sE..scPEP..E....PEPEPEPEPc..s...sEscPE...psEPEP.EPEPEP...E..PEPEPEPEPEP-Pssu..sh.......................................	0	6	17	17
+5717	PF05889	SLA_LP_auto_ag		Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen)	Moxon SJ	anon	Pfam-B_9614 (release 8.0)	Family	This family consists of several eukaryotic and archaeal proteins which are related to the human soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen). Autoantibodies are a hallmark of autoimmune hepatitis, but most are not disease specific. Autoantibodies to soluble liver antigen (SLA) and to liver and pancreas antigen (LP) have been described as disease specific, occurring in about 30% of all patients with autoimmune hepatitis [1]. The function of SLA/LP is unknown, however, it has been suggested that the protein may function as a serine hydroxymethyltransferase and may be an important enzyme in the thus far poorly understood selenocysteine pathway [2]. The archaeal sequences Swiss:Q8TXK0 and Swiss:Q8TYR3 are annotated as being pyridoxal phosphate-dependent enzymes.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.11	0.70	-6.00	5	254	2012-10-02 18:26:03	2003-04-07 12:59:11	8	5	169	15	177	1048	87	327.70	33	79.28	CHANGED	MDTsscsc..ssGlGEREuRVhocLspcslacFsHGlGRSGsLl-sQ.PKAsGuSlhs+LTNcLlpchL+hLGl+tlcssFVVPhATGMSLuLChouhR.++scAKhVIWPhhDcK...SslKAsppAGFchtlVEsll-GDpllTDlssVEctl.cchssEslLsVlSTsosFsPRsPDslcEIAcICu-YDVPHlVNuAYGIQspphhchlppAh+hGRlDAVVpSlDKNFhVPVGGuIIAAhc-salpEIScsYPGRASAsPstclLIoLLuLGssuYtcLh+cQKEsFshLcEpLccLuEchs..............EpllcsP-NPISSAhTlcsls.hpp...ts.spLuucLasR+VTGsRsVpsssshsT..........S+hppY.ssYlslsSAIGl+-EDV-pllcRL-csLc	...............................................................................s.p..t....hthGEREsRhhs.lht...h.............th..hHGlGRSGsl...t.Q.PKAhGuolh.plss.hh.phh+.....hGh........t..h.tt...s.h..hlP...hs.T.G.M.s.l.s.L.sh.s.h.......p...t....+...................p.u...............c.....h.....llas...p....l.....D.pK............os.a.Ku....h..tA...G....h...p.s..h..l....l...p...s...h...h.......p......s......-.......t....l...h...s...s....l...p...s...l..c..ttl....pc...h..G.......p...................s....l..L..s.l.h.o..T.sosF....u....PR................h..s...D..p.............l.....tpluplCtphslPallN......sAYu...l.......Q....s..p....h..h.p........l.p.t.s.....p...h.............GRlDs.hVpShD.KNF........hV.Pl.G...Gul..l..A...u.....s...t..p...h.................l...p...t.....l.......u...p....Y........sGRA........oto........s.................l-........l........h.h....o.L..L.......t...L..Gp.s.u..h.tp.h.lt.pp.h..t..a..h.lpp..p..l..p..chupph.s.......................................c.p.lhps.s.cN.IS....hsh.sh....p....s....h..t.t....tt....................p.th...h.luuhL..apRtl.oG.s.R....l....phts...............t..........sY.lshssslGhptp-l..phhhpplcchh........................................................................................................................................................................................................	0	68	98	148
+5718	PF05890	Ebp2		Eukaryotic rRNA processing protein EBP2	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_9615 (release 8.0)	Family	This family consists of several Eukaryotic rRNA processing protein EBP2 sequences.  Ebp2p is required for the maturation of 25S rRNA and 60S subunit assembly. Ebp2p may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis [1].  This family also plays a role in chromosome segregation [2].	18.80	18.80	19.30	21.20	17.50	15.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.03	0.70	-5.09	28	350	2009-01-15 18:05:59	2003-04-07 12:59:11	7	4	297	0	244	346	2	252.80	33	78.17	CHANGED	--sDh-Lp-h..tsphcsshsl.....hpcp+hsINNstuLpssLccIph......t.lsasE+.sls.......us..psh-.plpDhp........................DDhpREluFY+Qu.sAVhpAhspLcchsVshpRPsDYFAEMlKoDEHMpKl+pKLlsEtsuhctSEcAR+tR-lKKFGKpVQstplQcRp+EK+-hl-cIKph+Kp+p..........tt.-phDht..........h--sst.....tsstp+s..............tt..+stss...tKRptKspKFGaGG+K+tpKpNstpSosDhsGFss+h...................+ut...h.................sspRPGKu+R	...............................p-..lpp.h....t.....c.sthsh.....h.tp+.hsl.Ns.ssuLpppLpclph............phsahE+hsls...............................us......pshs.ph.Dhp............................DDh..p..R.EhuFY+Qu.s..AshpuhspLcphs.lPhpRPsDYFAEMsKoDpHMp.Kl+p+..LhpcpsshctuEcs++.RphKKaGKpVQ.sp............pl..p..cR..pc-K+..chl-pl.+ph+Kt+p....................cthDhh..................pcttt.......tpptppt............................ttttpt.tss..........tKRp..tK.spKaGa....G.G+K.+..ht.KpNstt..Sts.D.hsuap.tpth..........................+ut.........................tttR.GKthR..........................................................................	0	85	133	202
+5719	PF05891	Methyltransf_PK	DUF858; Hydroxy-O-Methy;	AdoMet dependent proline di-methyltransferase	Moxon SJ	anon	Pfam-B_9735 (release 8.0)	Family	This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyses the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognise the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified [1]. As with other methyltransferases, this family carries the characteristic GxGxG motif.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.46	0.70	-5.04	7	406	2012-10-10 17:06:42	2003-04-07 12:59:11	7	5	288	3	286	1393	487	201.70	37	81.52	CHANGED	ctcphYpcAlsYWpsVpsoV-GhLGGa...G...plsshDl.GScsFLppLhtc.hs...stppphhALDCGAGIGRlTKslLhchh...........scVDlVEPVppFlspucp.Lup......tpt+ssshassGLQ-aoP-....ts+YDlIWhQWClGHLsDp-LluFhpRCptuLpPsGhIVlKENhsppsh.hhDcpDsSlTRs-shh+plFccuGLpllupchQcGhPc....ELasV+MYALp	..........................................................................................YtcuhpYWp.p...l..suosc...Gh.L...G.....Ga......s......plsph...Dl..pu.Sp...pFLpc.l......h.t....t................................st...s....t.h....p....hALDCGA..GI.G.R....l......T...+p.l...L..h....h..h...........p..p..V......D..l...V..E...s.sp.pFl...p..ps..p..p......ltt.....................t.t.t...+.l....t...p...h..a..s..h.G.L.....Q..-..a..s...P.p........................t.p.Y.Dl.IW.h....Q.W.s..l.GH..L...T..D......p.c.......L..l..p.FLpR.C.+pu.L.........p...............s.....G......h..l....l..l...K...E.....N..h...s..p...........p.....s.....h.............hh.....D........p........p...D.....S......S..V..T....R.....s............p...h..h+p....lhpp..A.GLplltpchQpsh...Pc.........p..lhsVhhaAL.............................................................	0	89	151	227
+5720	PF05892	Tricho_coat		Trichovirus coat protein	Moxon SJ	anon	Pfam-B_9763 (release 8.0)	Family	This family consists of several coat proteins which are specific to the ssRNA positive-strand, no DNA stage viruses such as the Trichovirus and Vitivirus.	25.00	25.00	27.50	26.90	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.38	0.71	-5.09	11	513	2009-01-15 18:05:59	2003-04-07 12:59:11	6	5	30	0	0	510	0	176.60	48	77.61	CHANGED	hutptclRstl..........cshLhAths.spcs..ucsGhs+sh.......YLcolFG.IAlhGTSccTpah....................spVs.ltsphupc..hsshuphslpphVsph+saussss-GslpuhThRQlCEPFAppA+-sLlhhtphGsaopLhpKhscsGtKpPpVMFDFNsGLshptLo.tpctsVIpshNpRLFRTEGAKuVFsApuSssEpul-l	.....................................................................ucot..hE........hLcolFuNIAl.GTS-pT.pFh....................-hsspVKshtspc.....sl.GphsLpElVshlKsFpsTSS-sslsshTFRQlCEsFAspARshLVcht.+GlaTNLaspMPcsGpK.PplMFDFspGLsM...hhhs.hspppVIssMs+RLhpTEhAKu..EAp.uSsppsLpl............	0	0	0	0
+5721	PF05893	LuxC		Acyl-CoA reductase (LuxC)	Moxon SJ	anon	Pfam-B_9766 (release 8.0)	Family	This family consists of several bacterial Acyl-CoA reductase (LuxC) proteins. The channelling of fatty acids into the fatty aldehyde substrate for the bacterial bioluminescence reaction is catalysed by a fatty acid reductase multienzyme complex, which channels fatty acids through the thioesterase (LuxD), synthetase (LuxE) and reductase (LuxC) components [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.27	0.70	-5.75	13	358	2012-10-02 17:28:28	2003-04-07 13:39:30	9	4	316	0	112	2771	1191	335.20	21	69.60	CHANGED	hsslslppllshlhpsupcWpssp.phh..h...htphhuYspphhp..hct...hhhhCp+suLhcll-p-L.up.chLD-al...pts...sY.+AhP+GlshHlluGNVPLlslhSllculLsKNssllKsSSSDPhhsssLlpohh-lDsst.........slscolSVlYa.cuscspLscplh..spADsVlAWGG--Alchlsp.ptsspschlcFGsKhShull-ssA.....slspAsculAcDIChaDQpAChSsQslalp...ssslcEFspcLuptLs+hscllP+up.shsEpAthotpct-.....shhsth..tVh.pspspsWhllhSptt........thhspPL.pRolhl+tlscl.-llphlpps.ps..QTlul.hshpuphthhsp.LuttGVpRIscsGhhshacsGtsHDGhhsLpRLV+a	.....................................................................................................................h........................................................................................................t.....t.l................h........l.......t.............t...h...p..t...l....c..p..ah..........p..t...........t.........p...shsh.uh.sh.Hl.h.u.G.Nl.P.h.l.u..h.a.u.l.l.p.u.l..L.s.tNt.s.l.l..KhSu...s...-...sh..hhshl...h....p....ph....h.p...l..s.s.p.....................l.tp.p..l.s...l..l...a....ttt.........p.t..p..l....s.c..ph......s..p...s..D.....s..l...l.....u...a.G...G...s...p........s...l..c....h.hp....t....hh....s.s...p....s....p...h....l..t.....a....u.s.+.h.S...h..ulls.sps.......php.p.hh.p.t.hA.p.Dlh....h....ac..Q..uCtS...s.p.p.l.al.....t.............p.h.c.th.hp.........t.........l...ht.........t.........h........t....t...h....................h...h..s.....t....t....................s...........t....t....t..s...t..h...t....h.........t.............................h...tt....................h..................t.......t.h.............l....h.....p...........................ps...h......t......sh............l...h....l..s...ph.phh.........l.......t........QT.huh...h.....t.p.h......hs.......hh.hG..s.Rhs..G..........................aDG...h..l.phsp................................................................................................................................................................................	1	42	80	95
+5722	PF05894	Podovirus_Gp16		Podovirus DNA encapsidation protein (Gp16)	Moxon SJ	anon	Pfam-B_9825 (release 8.0)	Family	This family consists of several DNA encapsidation protein (Gp16) sequences from the phi-29-like viruses. Gene product 16 catalyses the in vivo and in vitro genome-encapsidation reaction [1]. 	20.90	20.90	21.40	27.10	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.24	0.70	-5.11	4	17	2012-10-05 12:31:09	2003-04-07 13:56:03	7	1	16	0	0	18	2	330.60	31	93.00	CHANGED	M-KKh.aap.pKlLSYstlhshlI..GARGlGKoYAhKph.lcchlppGcQFlYLRhYKoEltKspNpaFsDlt.paPspcFhVKG....p+hYlc..tchhGahIPLSshQu.KS.uYPNV.TIhFDEFlt..EKs.ssY.PNt....VcshlslhsTV.Rt+...-cVRslChuN...AVolhNPYFlhFth.Ps.NppapspsphllphlssccatsthRcsRFGphIsGhA..Yt-hSlDNpFsss......oclFV.++o+supasFuIhhsstphul.........WlDhppuhhahspu+sPcscpl.aALTscDL..sEsthLlhshpsshhLpphsSsa+KGhL+F-spVlRphhh-lht..hI	.............................................................h.ph.s..h.hhh..Gt+slGKoashp.h.hpchhp.GtphlhlRh.csphtph.ts.ah.sc..l......a.s..hc.VKs............................+chhhD..tKhh..GahhsLSshpph+usuYPpVpsIlaDEFh...-.Kc...NhsYlPNE....sstL.slh-oVhRhR...-cl+sIsLuN...usollNPYFs...aash...s.sKp.hp..tps-sL.l.ph.s.scsapsEp.p....tpLhcGou..YuchSLDNcFhss......p.h.l.+...t.....ptspKhlasIhas.sthlG.V.........Wh..sh.phhhhlspspDPsppsl.h.hp.sDh..ptt...l...hsphhh+hLssthhst.LhFDs..hRhlu.p..................................................................................................................................	0	0	0	0
+5723	PF05895	DUF859		Siphovirus protein of unknown function (DUF859)	Moxon SJ	anon	Pfam-B_9891 (release 8.0)	Family	This family consists of several uncharacterised proteins from the Siphoviruses as well as one bacterial sequence Swiss:Q8K6J6. Some of the members of this family are described as putative minor structural proteins.	20.10	20.10	20.50	20.50	19.60	20.00	hmmbuild  -o /dev/null HMM SEED	624	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-12.95	0.70	-6.26	11	110	2009-01-15 18:05:59	2003-04-07 14:01:24	7	5	86	0	4	104	3	484.90	28	85.00	CHANGED	Ms-FaSNNDRGY+lpLhV-QVuQ.sssNNTSpVRh+LsLhNs....TsTFupYsCsuhVphpGQplsaSupPShlohspolpLIDpTlTlsHsuDGoKThuhsApFsGSGGaSPGTLsIuupsaTLosIPRuSoVS....VusshlGsslTIsIsRpSusFTHslpYp.aGspsGsIuo.slsTSsoWTssl.DhAspIPNSTSGpGTIhVcTYssGshIGop..osshphsl.PsSV+PohoGIoLoDsNosAppllsuss.FlQIhSNl+VsFNGAoGtYGSTI..pGYaAEI........VGtNQosspNGGsLG..hhNasGpsTlRApVoDSRGRpS-sh-spIolLcYFuPuLsFostRsGpsssplslhRpA+IAPLoVNGlQKNpMpLTFclusluossaosDsGsASGsWoshopLssos..AsLuGsYsusKSapVhGpLpDpFoSTsFphsVssEpVVh.......oh-+sG.lGIGKhhE+...GuLDVsGDIYA......ssp.IQQaQLT.NNGts........hpps...Nhl.-sGthhlssSu.sNPs...u...hh...hp.pss.p.hhQTFhuss..hhh...p.sh..ssWtsWpcaupscshsh............hpTsWp.sGhps..shat+sGsshThp.....hph.sst......cshslsshPpchhss...ahhslsu	................................................................................h.h.h...p....s..up.shssNoSpVphphhl...ps.....shoas....h..s......s....h......l.lsGpphp....o...spssh...........s.s..pp.h.L.hstphT.lsHsuDGoK.ohs......h.Aph...ss..s...sGhp...s..sl.s...h...stshsLssIPRuS..o..lo..........ss.sshl.G.s.sholsIs..Rt..SosF...oHsl..pYp...au...ut.pts....l.us..sh.s.T....osoaT.sl....s......hA...splPsusSGssslhlp..TasGus...lGsp.....ohshshsl..Ps..o..hcPohs.u..l.olo-ssshstpllssss..FlQhhSplplsh...ssusG.YGSTI..puYpsEl........sststssssss.u....thG...hhshsGphTlpApVsDSRG+pSsshshplsVltYhsP.th.s.a.sshRsspsss........lp..lhhpspI.u.Plslsu..pKNhh.p.loapss.hss....s.hshsputAu....ass.....pphstss..hsh..u.G.....sassspSa.lhshlpDtFs.s....s.p.h...phs.lss..tpVlh.......shs...psG...lulG...Khh-p.............G..sl-s...G..sh.h......ts..h.....p.h.pLh......................s.h..sG.hh.....ss......spP......................................................................................................................................................................s.............................................................................................................................................	0	0	1	3
+5724	PF05896	NQRA		Na(+)-translocating NADH-quinone reductase subunit A (NQRA)	Moxon SJ	anon	Pfam-B_3622 (release 8.0)	Family	This family consists of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins. The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.35	0.70	-5.20	77	764	2012-10-02 20:27:15	2003-04-07 15:35:01	6	4	731	0	166	1388	819	253.40	47	56.78	CHANGED	hI.pIKKGLDLPIsGsP.p........Q.tIp.susssppVAllGp-YhGh+.PoMhVc.GDpVKtGQsLFpDKKssGVhFTAPuSGpVssIsRGt+RVlpSlVI-l-..s...p........-p.sFppastt..pl...ssLsp-pVpppLlpSGLWTAlRTRPaS+lPss-u.sPpuIFVoAhDTsPLAADspllIspppps......FpsGLslLu+LTsG+.Valspsssss.lPhs.....shssVp.hcpFsGPHPAGLsGTHIHalcPl.uts+sVWplsYQDVIAIG+LFhTGcl	.................................................IpIKKGLDLPIsGtP..p.........Q..sIp...su....slppVAl....lG...--YlGM+..PoMtV+tGDpVKKGQsL.F.E...DK.K.s..PGV.h...F...TuPsSGpVs...s....I.....s......R.....G....t...+....R.....V.....L.....Q....S......V...VIcl-..G...s........-pls..F..s.c..a.s..s.p...pL....usLsp-pV+...ppLlpSGL........W....T....A....l.R.T.R..P...F....S...K...l....P...s....s....-...u...pP....p.....u...I...F.V..o.AhDTNP.L.AADPpllIppp.p..cs...........FpsGL.s.l.L...o.+...L..T.c..u...K...V..al.C..p...s.....s...s..s.......s...lPtp.........shss...Vp.....hcpF.sGPHPAGLsGTHIHFl..pPV..uts+s.....VWpI...sYQD.VIAIG+LFhTGcL...................................................................................................................	1	45	95	138
+5727	PF05899	Cupin_3	DUF861; 	Protein of unknown function (DUF861)	Moxon SJ	anon	Pfam-B_2000 (release 8.0)	Family	This family consists of several proteins which seem to be specific to plants and bacteria. The function of this family is unknown.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.32	0.72	-4.59	33	1583	2012-10-10 13:59:34	2003-05-01 16:21:48	7	10	1032	14	492	2347	591	76.00	27	46.50	CHANGED	tstsushptGlWpsoPGcaphphsp.pEhs....allpGclpls...........s-....sGps......hplpsGDhhhhPtGh......pusWclt-s.l+....KtY	...............................h.t.ptshhhshac....s.ss.G...p.............h....p....h....h....h....s...p....t...E..hh...........al..lpGplpl.s...........st.......sGcs......h.p.lssGDhhhhPsGh.........pssWcs.th.h+Kha.......................................	0	106	251	370
+5729	PF05901	Excalibur		Excalibur calcium-binding domain	Moxon SJ	anon	Reference 1	Domain	Extracellular Ca2+-dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserved DxDxDGxxCE motif, which is strikingly similar to the Ca2+-binding loop of the calmodulin-like EF-hand domains, suggesting an evolutionary relationship between them. Functions of many of the other proteins in which the novel domain, named Excalibur (extracellular calcium-binding region), is found, as well as a structural model of its conserved motif are consistent with the notion that the Excalibur domain binds calcium. This domain is but one more example of the diversity of structural contexts surrounding the EF-hand-like calcium-binding loop in bacteria. This loop is thus more widespread than hitherto recognised and the evolution of EF-hand-like domains is probably more complex than previously appreciated [1].	21.00	21.00	21.10	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.86	0.72	-3.61	68	1070	2009-01-15 18:05:59	2003-05-01 16:38:01	6	44	876	0	230	825	85	37.90	39	17.10	CHANGED	shpsCsphpusstAthaht..................psshss.....cL...........DtDsDGluCE	.............................................atsCpphpss.s.us.lhts.................................cPuYss...........+L................DRD..p...DGlACE.....	0	63	151	202
+5730	PF05902	4_1_CTD		4.1 protein C-terminal domain (CTD)	Moxon SJ	anon	Reference 1	Domain	At the C-terminus of all known 4.1 proteins is a sequence domain unique to these proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although  such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by sequence alignment as encoded by exons 18-21. Comparison of known vertebrate 4.1 proteins with invertebrate 4.1 proteins indicates that mammalian 4.1 exon 19 represents a vertebrate adaptation that extends the sequence of the CTD with a Ser/Thr-rich sequence. The CTD was first described as a 22/24-kDa domain by chymotryptic digestion of erythrocyte 4.1 (4.1R). CTD is thought to represent an independent folding structure which has gained function since the divergence of vertebrates from invertebrates [1]. 	25.00	25.00	26.60	26.60	23.90	18.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.67	0.71	-4.03	9	519	2009-01-15 18:05:59	2003-05-01 16:43:59	8	12	80	0	154	372	0	107.90	60	12.64	CHANGED	ts-Isocchslstspspshs.pshph..ssss.-sslLlospTITuEohSTTTTTHlT....K........................TVKGGlSETRIEKRIVITGDsDlDHDQALAQAI+EAKEQHPDMSVT+VVVH+ETEl	.......................................................................................p.....hp-sPllpTETKTI..TYE....us........ph...D.s.s.....s.....sh-...sGV..LhoAQT.ITSE.T....s.S....TT.TTTHIT.....K........................TVKGGISETR..I..EKRIVITGDuD.ID.HD.Q....A.....LAQA.IKEAKEQHPDMSVTKVVVHpETEl.....................	0	21	33	77
+5731	PF05903	Peptidase_C97	DUF862;	PPPDE putative peptidase domain	Bateman A	anon	L. Iyer	Domain	The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of predicted thiol peptidases with a circularly permuted papain-like fold. The inference of the likely DUB function of the PPPDE superfamily proteins is based on the fusions of the catalytic domain to Ub-binding PUG (PUB)/UBA domains and a novel alpha-helical Ub-associated domain (the PUL domain, after PLAP, Ufd3p and Lub1p) [1].	29.20	29.20	29.20	29.40	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.12	0.71	-4.43	41	818	2009-01-15 18:05:59	2003-05-02 09:40:48	9	22	288	2	549	790	22	135.60	31	40.10	CHANGED	t.VhLpVYDLo...p....................shhLGh...........Gl..aHoul........laGp.Eahauu..........sGlh..................pspPtp.....p.G.p.pcsl......lGpTclsppthcpal...pplup..c.....apussYcLls+NCNcFosclsphLsGcpI.....PsalpcLsphshphshsptl...hshhh	...................................................h..VhL.VYDls......p............................hhhlGh................Gl..aH.oul..................laGh.EahaGu............sGlh.........................pspPtp............s.sh.phccsl.............hlGp..Tp..hstp..phpphl.....cplup...p.........apussYcLlp+NCNcFosplsp.h.L..s...G.......p.......t...I..............Ppa.lscLsphs.....hht.h........................................................	0	198	333	456
+5732	PF05904	DUF863		Plant protein of unknown function (DUF863)	Moxon SJ	anon	Pfam-B_7732 (release 8.0)	Family	This family consists of a number of hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	25.00	25.00	32.60	32.60	18.90	21.50	hmmbuild  -o /dev/null HMM SEED	805	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.64	0.70	-6.27	7	79	2009-01-15 18:05:59	2003-05-02 10:12:57	6	3	15	0	56	66	0	465.10	22	72.35	CHANGED	hhs..shSh...........ctuostpssl...shh.tpsspV.pspss........KhR++MlDLQLPADcYlDs-ptps.Gpp....................cphpssspp....p.ppssssss....lsl....psopGluDLsEP...............Vpsppspshu..hohDhhu+hsss.ucspsptlphs...............s............................EssptKsss+ssu....stp.ls.ssp..p.h.spu.p........P.....ps..phthhcERophshE....hppts.th.hps...l-tusssphPp.s..h.p.......s..h..hsH..uu....osuhsp+s...hssQppPhh........................phcosupsssuhssp..shspNthhpG.SssStpp.h.hsuhs.p..s.s.tt.sspt.hhp....................shp.s.ps...................tpppp.sslPWLp..t...p....................................t.hsLpss.........................ps..tssh..hclp.ssspppppIhh..h.tp..hs.....cp.s.......uhhhust.pclpp.h....hsLshN.ss-hsh........s...ptccstct...AssRshIDLN..ssoEDp.Epsshsup.th......psKh.h.IslEs..s.Es...-.p..........pcps........t.ssss.sEhh+hAAEuIVAI.....spcs.ssuSs.s-h..pp..LpWFs-hhtoptp-h.pp.-h..t...........sssphD.FEuhTLpLpETpt-EYhscPhsP..E..ph-c.os....s.s+PRRGpARRGRp+RDFQ+DILPGLsSLSRHEVoEDlQhhsGlh+usshsWp.SGhs+....hpussRGR.....hpss..sp..........sssssshsp..ss............DpulsGWGpsTRRsRRpRCP	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t....AAp.ll.h.............hp..sp.......l.hFsp.h..............p....t...h.....t.ptt.......sttshD.FEthTLpLpEhp.--hhshs.hs..t..p.cp.........p+.hpsphRRuRp.h.+DFQ+-ILPuLsSLSRpElsEDlphhtshhpupthphp.os.h.sc.ts..tsts.R.s+.....................................................................................................................................	0	6	31	43
+5734	PF05906	DUF865		Herpesvirus-7 repeat of unknown function (DUF865)	Moxon SJ	anon	Pfam-B_9911 (release 8.0)	Repeat	This family consists of a series of 12 repeats of 35 amino acids in length which are found exclusively in Herpesvirus-7. The function of this family is unknown.	20.10	20.10	24.10	87.20	17.70	16.30	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.70	0.72	-4.37	2	12	2009-01-15 18:05:59	2003-05-02 11:12:20	6	1	1	0	0	12	0	35.00	95	98.36	CHANGED	MGSHPFRQEpPpPHNPLTFKPVKTTGTAVsFSAGF	MuSHPFRQERPQPHNPLTFKPVKTTGTAVAFSAGF	1	0	0	0
+5735	PF05907	DUF866		Eukaryotic protein of unknown function (DUF866)	Moxon SJ	anon	Pfam-B_8299 (release 8.0)	Family	This family consists of a number of hypothetical eukaryotic proteins of unknown function with an average length of around 165 residues.	22.90	22.90	23.20	23.10	22.10	22.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.17	0.71	-4.74	9	382	2009-01-15 18:05:59	2003-05-02 11:19:09	8	12	290	2	254	373	4	144.50	32	84.37	CHANGED	MV+huLplpAsLENlpsLpPst....psa.aahKlKCsNCGElo-Khptlohs-pVsh.uG+usu.Nhs.KCKhCuREsSIsIlsushpshsh-DS..tchpsIssF-CRGhEPl-FtPpssWtApusEoGo.Fc-IDLpEt.-Ws-YDEKspsoVuIhphcppFp...hhK	..............................hhL.lpAp.L.cslsplpP.s.........psa...ahh+lpC.ssCtEhptphhhl...sh...-..ph..th....u...u+......G.p............A..shl.K........C.KhC.t.................+-sShs..l.....h...s...........s.....p....h..............p.....s....hs..h.c......ss.....................tchpsl...ltF-CRG.lE.s-FpP............p......s............t..ahspuh.oGshF..p....sl.cL..p........-t....-WhDYDEKstppVulhclphph....h....................................................................................	0	80	135	205
+5736	PF05908	DUF867		Protein of unknown function (DUF867)	Moxon SJ	anon	Pfam-B_7778 (release 8.0)	Family	This family consists of a number of bacterial and phage proteins with no known function and is present in Bacillus species and the Lambda-like viruses.	27.10	27.10	27.60	30.10	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.19	0.71	-5.22	37	384	2009-01-15 18:05:59	2003-05-02 11:22:44	6	3	199	2	70	273	50	188.60	34	69.65	CHANGED	Ypsap-Lppspp.tpDapIphpph.s.oplllhA.HGGuIEsGTSElscthu.....ssaShYlFEGl+tps.NpsLHlTSs+FD...EPhslphlpppchslolHGYtspp.......ppshlGGpDcthuctlscpLpptGFss....tstsscluGhpssNIsN+sp......sutGVQLElSsu.RcshFcshshppcsht.....spshhcalpul	....................atshs-Ltpppt.....DapIcsppp.s.SplhllA.HGGGIEsGTo...ElA.ctlA.................phssashYhFcGl+pp.......s...N..p.pLHlTSo+F...D....-Phhhchlc.p.p..phslSlHGhsusc.......phlhlGG.p.....Dcp.L.tptlscpLpp.t.....GasV..............tssP.pcluGhpssNlsN+sc......p.s..sGlQLELostlRcthFcshphspcshpp....s.hhh.pasp..................	0	14	34	60
+5738	PF05910	DUF868		Plant protein of unknown function (DUF868)	Moxon SJ	anon	Pfam-B_8013 (release 8.0)	Family	This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	20.60	20.60	22.40	21.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.14	0.70	-4.94	19	260	2009-01-15 18:05:59	2003-05-02 11:39:36	7	9	24	0	155	257	0	251.40	32	81.23	CHANGED	tsuspssVTslYpscl..ss+.tl.lplTWo+shh.....ups.Lolslssss................................pshs+hsh.pPhhFt+++GS+....................sh.pssusp...l..-laWDLosAKF...uu...uPEPlsGFY.VAVVsssEllLLLG......Dhc+-sh++stss.......sushlu++E+la..........G.p+hasTKApF..t-sGppH-lsI-C.......sssG.....tp....s.plhlslDuKhVlQV++LpW+FRGNpTlhl.DGhsV-lhWDVHsWLF..........u..suss...p..........AVFhF+sp....tu.-p.....................phh.pttstsssp...p....................t.sFsLllhAaKh	.........................................s...pshsoslYpspl........ttt.th.lsloW..s+shh......spu..Lslslp..sss.......................................p..h+hp.h..pP.hh.h..h+++.....GoK......................ph...pst.us.p......l..claWDLssA+F......uu...uPEPhss.aY.Vul.VsctEhsLlLG.........Dhpc..-uh.......++ptst......s.h...psshlu++E+lh...........G.p+hasT+ApF...t-.pGp.H.-lsI-s......................tttu............t-....s..phhlplDuch.llpV++LpWKFRGNpsl....hl..ssh.VcVhWDVHsWLF...................................s..ss.s.......p...........AlFhF+st........s.pt..................................................................p.................................................................tFsLhl.Ah+.............................................................................................	0	12	87	123
+5739	PF05911	DUF869		Plant protein of unknown function (DUF869)	Moxon SJ	anon	Pfam-B_8094 (release 8.0)	Family	This family consists of a number of sequences found in Arabidopsis thaliana, Oryza sativa and Lycopersicon esculentum (Tomato). The function of this family is unknown.  	40.00	40.00	45.50	41.20	39.80	37.50	hmmbuild  -o /dev/null HMM SEED	769	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.73	0.70	-13.58	0.70	-6.30	12	276	2009-01-15 18:05:59	2003-05-02 11:43:02	6	6	18	0	199	290	0	328.00	19	77.52	CHANGED	KEsLltQHuKVAEEAlsGWEKA-sEshuLKppL-sss.tphshE-RsuHLDuALKECh+QlRps+EEpEpplpDshtppopph-phchpLEt+lt-hppclhcssuENssLoc.Lpt+pphl.clscp+s.h-sphpsLpspL-usEKE.soL+YEl+slpKELEIRscE+shSh+SA-sAsKQHLEslKKIuKLEAECQRLRshVRK+LPGPAAlApM+.EV-th..upshs-sRppts.u..p....................................pp...hpccs..hht+hhthE-EsKhL+-uLuc+ssELQhScNhhAcpsuKLp.h-sph.................................t.hsEpt..-DthSsupSWA.suLlSELpph.KpcKt.spuphtpssu.clpLMDDFLEMEKLAs...lsstussssppsspstsscppsthst..pppt..ps.................................p........t+hltplp..plLccIctphsphppupspsppp.p...................................sh.pp.pshpp..hs..pcLpshluph.....pchht.Lpp.hphhp-...tpsshpchlp-hshshphhlsp.psLp-...........ttplp..h.h...................................................................pchEphcspptphth.........p..p.ph.....pE.EpplpplpspLp.tspcSpshsEsplcshspp.culc.+t.clc.chp.hp.plppL-sELpcE+tspp-thsKsp-lcpclp+.ppptsttph.......cp-h+h+Q-pEIuuAAEKLAECQETIhsLG+QLpoLp.s.p-thlso	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t................................................................................	0	29	121	163
+5740	PF05912	DUF870		Caenorhabditis elegans protein of unknown function (DUF870)	Moxon SJ	anon	Pfam-B_8400 (release 8.0)	Family	This family consists of a number of hypothetical proteins which seem to be specific to Caenorhabditis elegans. The function of this family is unknown.	27.10	27.10	27.20	27.50	26.60	27.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.63	0.71	-4.27	6	55	2009-01-15 18:05:59	2003-05-02 11:45:43	6	4	5	0	55	53	0	106.80	24	63.69	CHANGED	pFpAtIcCslstsaWCG-LYllEcDshh....................................................................HDlLppcKFCTSEppKph+FTVsPtsDF.oscaEhsYhhNHNCTADGcshCVKPpcopcVssast.+oVcFsI-AtsNGcsppCcsP	............t..th.lpCs.........t.....hWCuplhlaE.Dh.h.h...........................cDll.t.p.p.pFCo..s.pt.p....c...p...a.ca..s.h...p...s......suD....h..o..................spYEhshhlpHNCos.sG..p.h....h..Cl.p...p...h.s.h.....t.h....................................................	0	15	19	55
+5741	PF05913	DUF871		Bacterial protein of unknown function (DUF871)	Moxon SJ	anon	Pfam-B_8510 (release 8.0)	Family	This family consists of several conserved hypothetical proteins from bacteria and archaea. The function of this family is unknown.	21.50	21.50	21.50	21.50	20.80	21.40	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.62	48	1290	2012-10-02 15:38:38	2003-05-02 11:49:29	6	2	773	2	132	806	4	344.50	34	98.71	CHANGED	tLGlSlY.scs.thccscpYlchupphGFsclFTSLh.sc...sst.cphhpphpclhphApphshclhlDlsPplhppLsloapsLshhcc.hGlsGlRlDhGFospphAphops..slcIpLNhSs...........spchlcplhshpsshsplhusHNFYP+..TGLuhcaFhcpschh+chG..l.couAFlsup.ssppGP..lh-...GLPTLEpHRths.hspspcLhtsshIDclllGsshsScc-Lcpluph.pcphhpLclp...shs-h-tcll.cphHppRsDsuc.VlRSspoRh.....hht.ppsh.sp.ss.s.hp+GslsIDNptYG+YpGElQIshp-hssct+sNVVGclhc--l.LLchIcPhpcFphhtp	.....................hlGlSlY.pcs....hpcsctYlchutchGFpplFTS.Lh.sp....ccp.cphhpcapcllshApphshclllDlsPslhcpLshoap......s......L.p...........a.pc.hGhhGlRlDhGho.s..pp.uthotp..slK.IpLNhSs...........spphl.cslhshps..shs...p..LhuCHNFYP+..TGLuh-aF.cpschh+chu..l.p.o.hAFlsup..s.sph.G..P...lpc...GLPTLEpHRph..p...hst..uccLht..oshl..D-VlIGsshsSccplcplup..h..pcp..hhpLclp....tths-hppphl.h.p.p.hH.........h.RsDhsc.llRSs......poRh...................hhp..ppsh.....sp..po...t.t.hp+GslsIDNptaG+YpGElQIslp-..hss.cs.+sNVVGpIhc--l.LLshlp.sh.ppFphh.p................	0	42	78	105
+5742	PF05914	RIB43A		RIB43A	Moxon SJ	anon	Pfam-B_8571 (release 8.0)	Family	This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialised set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterised in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialised protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organising their three-dimensional structure. Human RIB43A homologues could represent a structural requirement in centriole replication in dividing cells [1].	25.00	25.00	32.00	25.30	24.50	20.20	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.17	0.70	-5.83	13	202	2009-09-10 21:00:25	2003-05-02 12:53:47	7	4	109	0	131	193	4	312.80	31	95.74	CHANGED	Ma+lcls...D.cEstAlE+RRstEpERpsRIFNu+sRshGVDlcALcpQVpE+KhpEpsE+p+-cuYsspphp.DclsthhccEpcpcp+pLs+clppFRppaQ+hEspREFDL..DP-sl+K.shPsRluD-Dsp...hGsSShQpFpGEDLppssR++hQpEQ.RpWlcpQhpE+ppActpc+pADplh-phthphDpRAtcLuphEcpsRptlppAspcaNcA.Accpptccppc+pp-p--NhAEIpNploSDhLTENPsVA....pSshuPaRVlstpWKGMoPcQlpsIRcsQ-pQhpEKccpRppEpth-tpWpppphphuRAhhhLEcpccRhp+ph+cpLsphNppLAtEQ..cAppcaLpcplYsNpPTspYapQFNToSR	.........................-.....tltt++ph-.pRppRhhss+.RhhGlDhpsLptQlt-+c.pcthEp.tcptthstp.ht.cplhthh-pctpcpp+tlp+tl.ppap.pp.h.Q.p.cppREaDL..DPtthp....................K.thPsc.us..sDsp....u.SuhQh.....F.GEDLshtpRp+hQpcQ.RtWh.pQ.pEppptctpcctt.-.thhsptphph.-ppttcltph-ppsRpthttshtpaNps.....Atcptpccppc+pp-pcsshsEItp.lp.uD.hLoE.sPp..A....tst..hu...s.pR..ll..s...paKGMo.-Qhptlpp.hQppQhp-p...tph.cp..t-pth-tpWp.ppphp.s+shh.h-cpppc.ppph.pctls...p.N..pLApcQ..ptppp.h.t.lh.p.NtsstpaatQFspssR.........................	0	54	63	92
+5743	PF05915	DUF872		Eukaryotic protein of unknown function (DUF872)	Moxon SJ	anon	Pfam-B_8741 (release 8.0)	Family	This family consists of several uncharacterised eukaryotic proteins. The function of this family is unknown.	22.10	22.10	22.10	22.20	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.77	0.71	-4.22	13	281	2009-01-15 18:05:59	2003-05-02 12:57:19	7	3	132	0	171	286	2	107.10	29	77.02	CHANGED	Y..psLss.D-D.............hcs...........pFspssss.p+ss...............h+sIhhAhhLLllGshLllhGhhlhss..t.ussspuhshhlhGhlhFlPGhYastlhahAh+Gh+GasF.plPsF	....................................................................................................................ht.........p.................................hKsIhlAhhLhllGs...h.LlllGshlhss....h.ht.....sssspuh.shhllGhLhFlPG.hYalh.lhYhA.h+Gh+GaoasplP.a....................	0	52	86	126
+5744	PF05916	Sld5	DUF873; 	GINS complex protein	Moxon SJ, Studholme DJ	anon	Pfam-B_8759 (release 8.0)	Family	The eukaryotic GINS complex is essential for the initiation and elongation phases of DNA replication [1-3].  It consists of four paralogous protein subunits (Sld5, Psf1, Psf2 and Psf3), all of which are included in this family.  The GINS complex is conserved from yeast to humans, and has been shown in human to bind directly to DNA primase [4].	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.75	0.72	-3.76	176	1118	2010-01-07 10:55:00	2003-05-02 13:00:16	6	12	372	22	798	1076	14	113.40	15	50.89	CHANGED	sclPhahut..Lhc....................pshspl..p..phhshc..hpthptp...............................tps.t..hplt...................................................................hthsph..........................p.+p.........................hlps..hh....ctRhtKlpphshph.......................................ttstthh..spLottEh	..............................................................................................................................................plPhahu....L..hp................................p...hh..pl.......phhphp...hpthpt-...............................tpp....hslp..................................................................................ahp.h.sph.h......................................................cch+p.............................................hlps...hh.ctRhpKlpphs.hph.............................................ttstthhptLs..E.......................................................................	0	230	409	648
+5745	PF05917	DUF874		Helicobacter pylori protein of unknown function (DUF874)	Moxon SJ	anon	Pfam-B_8835 (release 8.0)	Family	This family consists of several hypothetical proteins specific to Helicobacter pylori. The function of this family is unknown.	21.90	21.90	22.10	22.10	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.50	0.70	-5.61	2	170	2009-01-15 18:05:59	2003-05-02 13:02:31	6	4	43	0	11	184	0	203.70	45	100.99	CHANGED	M.sl+sh........s.hAshhhph.pphKphpshpNlhhSlhGh..thhctl+s.lKKp.KKSs........hhCtpsKphDDhl......tp+.N..sWap.u.GlThhsuhLhssC.AsDpsKp.EltQtpKEAENARDRANKSGIELE.......QE+QKTpp.............KsEQE+QKTEQEKQK...........tspstIclEQppQKT.ppppch.ppQKDhlpcsEQNCQENHNQFFIKKLGIKuGIAIElEAECKTPKPsKTNQTPIQPKHLPNSKQPHSQRGSKAQEhIAYLQKELE.LPYSQKAIAKQVsFY+PSSIAYLELDPRDFpsTEEWQKENLKIRSKAQAKMLEMRsLKPDPQAHLsTSQSLLhVQKIFADVsKEIcsVANTEKKsEKAGYGYSKRM	...............................................................................................................................................................................Iclt.......QEpQKT.....................................................................................................................................pt.......p.....................................................................................................................................................................................................................	1	10	11	11
+5746	PF05918	API5		Apoptosis inhibitory protein 5 (API5)	Moxon SJ	anon	Pfam-B_8916 (release 8.0)	Family	This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterised by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors [1,2].	22.20	22.20	22.30	22.40	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	556	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.78	0.70	-6.01	3	205	2012-10-11 20:01:00	2003-05-02 13:15:00	6	6	113	2	125	191	0	385.30	36	88.30	CHANGED	pIEKLYEFsERLSESsDK.SQNV-DYEGIIKhSKTohKsKQLASQLIPRYFKFFPSLATEAFDAahDlhDDsDlGVRVQAIRGLPLFCKDTPDhlSKIlDVLVQLLNTEEPVERDAVHKALMSLlRQDTKASlTALFpHsusT.TTDEQIREKVL+FIRDKVlPLKGELLKPQcEMERHITDLIKKSLpDVTG-EF+MFMDFLsSLSIFGGKAP.ERMQELVEIIEGQADLNup...FphsDs-hl-RhIpChphAhPaFuRGAPSS+FLsYLNK+IlP..sFDpL.....PEERKLcLLKALAEMSPYTTAQ-.ARQlLPSIVpLLh.YMP........htcTs.phpFoasECLLYAhHpLu+KsPNATNSLCGYKIVTGQPSDRLGEDFSEhNKDFTERLThVEDLTKATMKKLTQGMoEHsKAMSsAKTDEEKuplKTK+.QsTTTGLRTCNNILAMTKsLatplPsFp+DhslsLSWhVssp....shlh++HtshoFh.............s.hspspohhGKRPA...NGuGNNV.uAKKuRsSN..QpQlVNKuuEGIS+sGu..SatGRGRsRGpGR+u..GGGRGRGp.sRGFW	......................................................................................t....lhp..thLsp.u.t..-....pp........p.tYp.IlpusK..u.s.sK.tKpLAuQhIs+FFppFPpLuppAlsA.hDLsE..D--...............h..t.lRhQAI+tLP.hsps......-.hs+luDlLsQ....LLt.......s.--ssEhphVppuLhslh+.DsKuoLsulFppl............p...s.-.....-.......hRE+....slpFlt..sKlhsh...phhp....pEhE..chlht..K.K.sL.p.D..VT..........u.pEF.hhM.phLtshp....ht.....shpuhpp.Llcll.p..QApLptt................hpss...Ds-...pl-Rhlp.Cht.A.hPhF..........sc.sspS...opFl.sahsc.p.llP...hstl...........................phpL..clLKhhAEhssa.......s.......s.s.-.....pp.l....lhphLhc.YMP.......................tt.p.p.t.....phpFoaVECLLashH.pLu++.hPs.ht.h....................u-phKDFp.R.....Lphhtc...hhp..shl+pL...p.uh...............pscstptl...K....scc..phphsuL+hssNI.slh+sLac.sP.ahss....ls.LSWh..tp..............................................................................................................................................................................pt........................................................................................................................................	0	46	63	92
+5747	PF05919	Mitovir_RNA_pol		Mitovirus RNA-dependent RNA polymerase	Moxon SJ	anon	Pfam-B_9906 (release 8.0)	Family	This family consists of several Mitovirus RNA-dependent RNA polymerase proteins. The family also contains fragment matches in the mitochondria of Arabidopsis thaliana.	25.00	25.00	27.70	27.30	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.78	0.70	-5.55	14	122	2012-10-02 12:54:00	2003-05-02 13:27:16	6	2	72	0	14	89	0	240.50	44	75.64	CHANGED	hphc.psphhsh.......+uGP.......suhShhoslhchhuhhtps..hphlphl...................h...h.hlsahpph..hhpsh...................hhsphtsh................lGKLulhc-stGKsRlhAhsDhhoQhlLpPLHshlFshL+plPp.DtTFsQp.shshhppchppt......aaShDLSAATDRhPlslQpclLshlhus.phupsWtsLLlsRsY..........tssss.lpYuVGQPMGAhSSWAhhsLoHHllVphuAh+s..ths.FscYlILGDDIVItscpVAppYhplMsc.LGVcIS.sKohlS..psoaEFAKRaht.stt-lSslslp..........uIlpslpp.hthhhs.lhchht+Ghp.......phls.h.ch.t..hlhh....tt.hhhsthhh....ht.......slphtpsllshpphhphltphh............t..hhs.thh................hshlhthlphshstphpslhhcphsphhhh.sphpsh.h.........hpp.pch.ph......L.tuh.hshh.plpchhsthhpptshsl.thhpshh...hshcsl	...................................................................................................................................................................................................................................llAMhDahoQhhL+PlHstLFphL+clPQ.DRTFsQssh.ch.ssccs........haShDLoAATDRFPIslQcclLhhl.............auc..phAsuW.tsllVpcta............hp.ths.lpYsVGQPMGAaSSWshFTLSHHllVphsAhhs...thspFp-YllLGDDIVIpNcpVAKpYlplMsp.LGVslScuKohVS....c..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	8	14
+5748	PF05920	Homeobox_KN	Coprinus_mating;	Homeobox KN domain	Moxon SJ	anon	Pfam-B_4610 (release 8.0)	Family	This is a homeobox transcription factor KN domain conserved from fungi to human and plants.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.08	0.72	-4.25	99	3978	2012-10-04 14:01:12	2003-05-09 13:11:53	6	46	463	5	1329	4786	10	40.00	54	12.00	CHANGED	WLhpphpp..PYPoc...p.....pK..........p..pL......uppT..ulohp..........Q.........lss.....WFINAR+R	........................................WhtpHh..ca...PY.....PoEs.........................-K..............................h...tL......App.T..GLs..p.................................Q......................................lsN......W......F.INtR+R.......................	0	325	626	968
+5750	PF05922	Inhibitor_I9	Subtilisin_N; 	Peptidase inhibitor I9	Yeats C	anon	Pfam-B_52 (release 8.0)	Domain	This family includes the proteinase B inhibitor from Saccharomyces cerevisiae and the activation peptides from peptidases of the subtilisin family.  The subtilisin propeptides are known to function as molecular chaperones, assisting in the folding of the mature peptidase [1], but have also been shown to act as 'temporary inhibitors' [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.73	0.72	-3.41	160	3390	2009-01-15 18:05:59	2003-05-19 17:25:16	11	124	1056	23	1630	3258	93	81.50	20	11.78	CHANGED	pYIVhhcpt.........................................hstsp......hssttphhp...............................................tsslhpsYct.......shsGauupLspppl.cplp.ppPsVthlp.Dphhplp	..........................................................................................................YIVh.hppt........................................................t.tp.................tthtphhp....................t...............................................tttsplhps...Ypp..............shsG......au.u.p.l......s.p....p.p.....l..cp.l........p......p..p..Ps....V.t.t....Vp.-phhph...........................	0	332	967	1374
+5751	PF05923	APC_crr		APC cysteine-rich region	Yeats C	anon	Yeats C	Motif	This short region is found repeated in the mid region of the adenomatous polyposis  proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin [1].	19.90	19.90	19.90	19.90	18.50	19.80	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.34	0.73	-6.92	0.73	-4.15	30	697	2009-09-11 05:34:41	2003-05-20 13:04:25	7	65	69	3	367	643	0	25.90	45	5.86	CHANGED	s-ssppas.sEcTPhs.FS+so..SlSSLo	..........-s.ppas.lEsTPhs.FS+so...SLSSLo..	1	42	74	178
+5752	PF05924	SAMP		SAMP Motif	Yeats C	anon	Yeats C	Motif	This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin [1].	19.60	19.60	19.70	20.20	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.28	0.73	-6.64	0.73	-4.65	11	249	2009-01-15 18:05:59	2003-05-20 13:43:35	6	48	46	2	126	209	0	20.40	55	2.10	CHANGED	---.ElLpECIsuAMP++pp+	...s-D.-lLpECIsSAMP++pp+..	0	7	18	54
+5753	PF05925	IpgD		Enterobacterial virulence protein IpgD	Moxon SJ	anon	Pfam-B_1987 (release 9.0)	Family	This family consists of several enterobacterial IpgD like virulence factor proteins. In the Gram-negative pathogen Shigella flexneri, the virulence factor IpgD is translocated directly into eukaryotic cells and acts as a potent inositol 4-phosphatase that specifically dephosphorylates phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] into phosphatidylinositol 5-monophosphate [PtdIns(5)P] that then accumulates. Transformation of PtdIns(4,5)P(2) into PtdIns(5)P by IpgD is responsible for dramatic morphological changes of the host cell, leading to a decrease in membrane tether force associated with membrane blebbing and actin filament remodelling [1].	20.70	20.70	21.10	20.80	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.80	0.70	-6.29	2	189	2009-01-15 18:05:59	2003-05-20 14:51:26	7	3	152	1	10	130	1	503.80	70	94.95	CHANGED	MpIpsh.hHpsShpot-uaKuhpcT...pGhpllShQthtsuc...........Rp.GsphhN..YLQpQ.TS.puht.LashcRshlhhtAhhL.GtpsshlpuMhpQh-hhKl.............ucs.K+Nl.EL...IutchptQ.Gl.sKct...htsth+ph.sp.LNNpsWpsIppslsaNG+pYs.p.hPAucMKIGsKsIFsptYpGKGlCshsT+p.+HhsNhWhSpV.Vc--GK-..lFsGIRHGVlSsYt.cKss..RtVuAcNKAcElhoAALaS+.ELLspALuGcsVsLKlVSsuLLTsoslhGtEtoMlcDQh+AhppL.op.Gc.h+LhIRNpDG.LQpVKlp.cVssFNhGVNELALKhGhGh+ssDphNuEulhpLLGsshh.puh.GGWsuEhltp.PsshpsV.hLApQIK-Ihppp.p+pDsGEPYKLuQRhAhLAapIsAVPsWNCKSGKDRTGM.DuEIKREIIphHpTt.hSt.sSh.sSttp+lFpplLhNSGN.t.pE.NTGssGNKVMKpLs.psLpLSYtcRlGD.pIWp.VKGhSShl	........................................................................................................MpIpsh.hHpsShpot-uaKuhpcT.hapGMQILSGQGKAPAKAPDsRPEIIVLREPGATWGN..YLQHQKTSNHSLHsLYNLQRDLL...TVAATVL...GKQDPVLTSMANQMELAKVKADRPATKQEEAAAKALKKNLIEL...IAART.QQQsGLP.AKEAHRFAAVAFRDAQVKQLN...N..QPWQTIKNTLTH..NG..H.....H...YT..NTQLPA.AEM.K....I..GAKD..IFPS.AYpG.KGVCSWDT+NIHHANNLWMS.........TVSV.H.E.DGKDKTLFCGIRHGVLSPYH.EKDPLLRpVGAENKAKEVLTAALFSKPEL..LN...+AL...p...GEA...VSLKLVSVGLLTA...SNI.....F......G...........K.EGTMVEDQM..RAWQSL.TQP.GKM.IHL.....KIRNKDGD....LQTVKIKPDVAAFNVGVNELAL.K.....L.G...F..GLKASD+YNAEALHQLLG..N.........DLRPEARPGGWVGEWLAQ.......Y.........P.D..N.....Y...E......V.....VNTL...ARQ...IKDIW.KNN.HHKDGGEPYKLAQR.LAML......AH......EI.......D....AVPAWNCKSGKDRTGMMDSEIK.REhISLHQ..THM..LSAPG.S.LPDSGG....QKIF.QK..V..L..LNS...GNLE.IQKQNT.GGA.GNKVMKNLS..PEVLNLSYQ.KRlGDENIWQSVKGISSLI..........................................	0	5	6	8
+5754	PF05926	Phage_GPL		Phage head completion protein (GPL)	Moxon SJ	anon	Pfam-B_1860 (release 9.0)	Family	This family consists of several phage head completion protein (GPL) as well as related bacterial sequences. Members of this family allow the completion of filled heads by rendering newly packaged DNA in the heads resistant to DNase. The protein is thought to bind to DNA filled capsids [1].	19.80	19.80	21.70	20.60	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.51	0.71	-4.35	33	714	2009-01-15 18:05:59	2003-05-20 15:03:08	6	3	529	0	73	507	5	136.30	41	87.08	CHANGED	sIsNs.GFWPDlsltchRcthRl-uolsspRLcpAllsAhupVNs-Ltsa+spppuuGassLusVPu.spls.GcuhhltpYcRAVashA+AsLhE+YpshDsTss.GpcpAcclspohs-LhRDucaAIpclhGpsR.ssVELI	..................................................IpNs.sFWPDlslp-hRpthRl.sus.Vo..s..sRLppshhuAlucVNsELhpa..+ppppst..GassLA-..V.......PA......s.........p.l.............s..G........cShplhaYppAVashA+A.LhER.YpshDsTsp..G...s++u....-plspsts-LWRDs+WAIucltstP.R.shV-LI..............................	1	8	29	51
+5755	PF05927	Penaeidin		Penaeidin	Moxon SJ	anon	Pfam-B_2675 (release 9.0)	Family	This family consists of several isoforms of the penaeidin protein which is specific to shrimps. Penaeidins, a unique family of antimicrobial peptides (AMPs) with both proline and cysteine-rich domains, were initially identified in the hemolymph of the Pacific white shrimp, Litopenaeus vannamei [1].  	25.00	25.00	25.50	26.30	20.30	20.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.98	0.72	-3.44	8	55	2009-01-15 18:05:59	2003-05-20 15:26:31	6	1	11	2	0	54	0	72.10	65	97.04	CHANGED	MRLVVCLVFLASFALVCQGQuYKuGYTRPlPRP.......Pa.....G.tshtsh.slC.suC+tLohSpARuCCsRLGRCC+htKG	................................MRLVVCLVFLASFALVCQGQsY+GGYTRPlPRP...........Pa.....G..t.....Phhsh.suC.suC+..sIohSpAR.uCCpRhGRCCHlhKG..	0	0	0	0
+5756	PF05928	Zea_mays_MuDR		Zea mays MURB-like protein (MuDR)	Moxon SJ	anon	Pfam-B_3145 (release 9.0)	Family	This family consists of several Zea mays specific MURB-like proteins. The transposition of Mu elements underlying Mutator activity in maize requires a transcriptionally active MuDR element. Despite variation in MuDR copy number and RNA levels in Mutator lines, transposition events are consistently late in plant development, and Mu excision frequencies are similar [1].	20.80	20.80	21.20	23.40	18.10	19.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.37	0.70	-4.90	4	19	2009-01-15 18:05:59	2003-05-20 15:35:39	6	1	2	0	1	21	0	203.00	85	94.63	CHANGED	MDhPPSKVVADAVEAARAAAVAASEARCAVFVAEKEAKAAVQFAAIAVDKVEAVKASSNVDLVDFKYHVNIKNSLRYAIQEMRRQoKLLHSVQKLCSTIPEVQGGKIGKVRGHLEHVCKELDKTSIVCEEDLETKNPTWDLYDNPSVDDEHPLDDDELGDGYSTEDPELWEMVF-DFKWEEIKANVSFEEHYRVINYRFEEINDRNM	.......MDhPPSKVVADAVEAARAAAVAASEARCAVFVAEKEAKAAVQFAAIAVDKVE....AVKA......SSNV...DLVDFKYHVNIKNSLRYAIQEMRRQoKLLHSVQKLCSTIPEVQGGKI.GKVRGHLEHVCKELDKTSIVCEEDLETKNPTWDLYDNPS.V.DDEHPLDDDELGDGYSTEDPELWEMsFEDFKWEEIKANVSFEEH.RVINYRFEEINDRNM..............	0	1	1	1
+5757	PF05929	Phage_GPO		Phage capsid scaffolding protein (GPO) serine peptidase	Moxon SJ	anon	Pfam-B_1730 (release 9.0)	Family	This family consists of several bacteriophage capsid scaffolding proteins (GPO) and some related bacterial sequences. GPO is thought to function in both the assembly of proheads and the cleavage of GPN [1]. The family is found to function as a serine peptidase, with a conserved Asp, His and Ser catalytic triad, as in subtilisin, and as represented in MEROPS:S73. The family includes SwissProt:P25478 from Enterobacteria phage P2 which cleaves itself and then becomes the scaffold protein upon which the bacteriophage prohead is built - a mechanism quite common amongst phages [2].	21.50	21.50	22.80	22.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.87	0.70	-5.15	5	734	2009-01-15 18:05:59	2003-05-20 16:35:53	6	3	536	0	77	566	6	255.80	42	93.46	CHANGED	SKaFRIAVEGATTDGRsIpR-WI--MAAoYDPcVYGARINLEHIRuhLPDGsF+AYGDVTALKAEEI-.sG..sGKLALFAQIEPT-DLlslNKu+QKlYTSMElsPKFADTGKAYLVGLAVTDsPASLGTEhLoFu.toAKsNPLAsRKQNP-NLFTsAEEssLEFEE.....lsE..oVssuLhs+VKsLFs+K-ASD...DARFuDVpEAVEsVAEHVQs..utTEppLuEtE+Ahot.cQplsspt-cpspsFscLKsoL-+T-uhuQptRPsATGGGu..slLTDC	....................KhFRluVEGsT.sDGRpIptpalppMAcoYsP.p.V.YsApINlEH........h+..u..hh...P...s...u....F.p.paG-VsuLp.uE..-..Is-..ss...LtGK..hALaAclpPT....-c.Llph.s.+.puQKlaTShE..lpP..p.FAsTG+AYLVGLAsTDsPASLGTEh.LpFs.....tps.p........p.ss.......l...s...sp........+.....t..s.s...t..s....L...h.os..A....-s.t..l..E..h....p-................tp...p.t.s.sh.hs...+V.p..ul......h...s...+...pptuD....................DApF..s...cl..pc....A......Vp.h..VApp.p...p...h.s...th...pttLs-.c..pp.........t......cptl............p.....t......p....pthstL...pppLp...p.p-u....p.......R...pATG.usu....s.hss...............................................................................................................................................................	0	10	33	56
+5758	PF05930	Phage_AlpA	AlpA; 	Prophage CP4-57 regulatory protein (AlpA)	Moxon SJ	anon	Pfam-B_2048 (release 9.0)	Family	This family consists of several short bacterial and phage proteins which are related to the E. coli protein AlpA. AlpA suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light [1]. Several of the sequences in this family are thought to be DNA-binding proteins.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.25	0.72	-4.24	23	2885	2012-10-04 14:01:12	2003-05-20 16:46:44	7	8	1195	1	461	2198	442	49.80	31	65.72	CHANGED	pRhlRhtEVhphsGluRosIYchhc......cs.cFPppl+LGsRuVuWhpuEl-pWl	............................hlchtplh.phs.G...l..o.cs.tl.Yc.h.lp.........cG..pFP..p.s.l.+..l...G...............R...s.....s..s.......W.h..poElctWl....................	0	82	241	355
+5759	PF05931	AgrD		Staphylococcal AgrD protein	Moxon SJ	anon	Pfam-B_2868 (release 9.0)	Family	This family consists of several AgrD proteins from many Staphylococcus species. The agr locus was initially described in Staphylococcus aureus as an element controlling the production of exoproteins implicated in virulence. Its pattern of action has been shown to be complex, upregulating certain extracellular toxins and enzymes expressed post-exponentially and repressing some exponential-phase surface components. AgrD encodes the precursor of the autoinducing peptide (AIP).The AIP derived from AgrD by the action of AgrB interacts with AgrC in the membrane to activate AgrA, which upregulates transcription both from promoter P2, amplifying the response, and from P3, initiating the production of a novel effector: RNAIII. In S. aureus, delta-hemolysin is the only translation product of RNA III and is not involved in the regulatory functions of the transcript, which is therefore the primary agent for modulating the expression of other operons controlled by agr [1].	20.50	20.50	20.70	20.80	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.30	0.72	-4.33	21	248	2009-01-15 18:05:59	2003-05-20 16:54:19	6	1	222	0	8	56	0	45.10	49	97.59	CHANGED	hplhshlhchhstlFphIGslAuhssCsuaFDEPEVPcELTcLac	.........ppLhNhFh-hlsslhcsIG.lAuhssCshlhDEsEVPcELTpLaE....	0	2	2	8
+5760	PF05932	CesT		Tir chaperone protein (CesT) family	Moxon SJ, Bateman A	anon	Pfam-B_2921 (release 9.0)	Domain	This family consists of a number of bacterial sequences which are highly similar to the Tir chaperone protein in E. Coli. In many Gram-negative bacteria, a key indicator of pathogenic potential is the possession of a specialised type III secretion system, which is utilised to deliver virulence effector proteins directly into the host cell cytosol. Many of the proteins secreted from such systems require small cytosolic chaperones to maintain the secreted substrates in a secretion-competent state. CesT serves a chaperone function for the enteropathogenic Escherichia coli (EPEC) translocated intimin receptor (Tir) protein, which confers upon EPEC the ability to alter host cell morphology following intimate bacterial attachment [1].\	    This family also contains several DspF and related sequences from several plant pathogenic bacteria. The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. DspF and AvrF are small (16 kDa and 14 kDa) and acidic with predicted amphipathic alpha helices in their C termini; they resemble chaperones for virulence factors secreted by type III secretion systems of animal pathogens [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.52	0.71	-4.26	52	1366	2012-10-01 22:01:34	2003-05-20 17:02:43	8	4	525	41	194	749	35	112.90	19	76.61	CHANGED	pLlpphuppluh...slshscsusssLth..spthhhlhhsppsspLllts.luphssstt......hhpplLphNh.h.tphtsshlulc.pssplhLptphshpt...lsts.phpshlpthlstscphp	......................................................hlpphupplsh...slt...h..s..p..s.shhtlhl....sp.hhhh.h..h.s.t..p...sp..h...l.hlhshlst.s.sss.s..........hhtplLph.N.h.h.tppssstlu.hs.pstpllLhhphshsp...hssp.pltshlpshlpphcth............................	1	71	103	148
+5761	PF05933	Fun_ATP-synt_8		Fungal ATP synthase protein 8 (A6L)	Moxon SJ	anon	Pfam-B_2993 (release 9.0)	Family	This family consists of fungus specific ATP synthase protein 8 (EC:3.6.3.14). The family may be related to the ATP synthase protein 8 found in other eukaryotes Pfam:PF00895.	24.20	24.20	24.30	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.34	0.72	-3.93	18	148	2012-10-02 21:03:42	2003-05-21 09:35:49	8	1	141	0	36	135	596	47.90	49	86.49	CHANGED	MPQLlPFYFlNplsauFlllolLlYlhSpYILPphlRLalSRhhIs+L	..MPQLlPFYFhNQlsauFlllslLlYlhSpYILPphlRLaloRhaIsKL.........	0	12	25	31
+5762	PF05934	MCLC		Mid-1-related chloride channel (MCLC)	Moxon SJ	anon	Pfam-B_2711 (release 9.0)	Family	This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer [1].	25.00	25.00	26.20	25.40	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.21	0.70	-12.78	0.70	-6.21	2	95	2009-01-15 18:05:59	2003-05-21 09:46:09	6	3	52	0	42	97	0	343.90	40	92.71	CHANGED	hpLhLh.sLhLsssYu.asD-WIDPoDMLNYDAASGpM+p.....................oQt.hthusEhc.sPDhoCusEhpEhhpKL-sLphpl-..EpK+hEc.cSpSpslF+RYLNKILIEAG+lGLPDEshschHYDAEllhphEhL.EIQpFLNstDWpsGALDDALSshLlpFKaHs.EpWKW+FEDSFGVDsYslhMllLClLClVhLlATElWTaltWaTQL+RlLIlShlhShGWNWMYLYKlAFAp+QAElAKhpshsp.CupKhsWotSla-Wh+uuhTapsDPCpcYachLlVsPhhhVPPTKALAlTFTsFlTEPLKHIGKGhGEFlpALhpEIPhhhplPVLIhhAlhlLuFhYGAGpuV....plhR+lsGPEpE.P.slcPpcppRpc.I-..........Dh+h.sthG...............pl.R-pDV..........spl.+t.slsDh-upppPsV.......shsscPp-TGtlhupsTsc..spEspp.tKsl..StpDppsNTEus.At.p..........................Rsp-PVspsht	..............................................................................................................................................hlh...h..hh...s..t...sD-.WlDPtDMLNYDusotpM+p..............................t.......p.....s....t.......s.p.tp...h..pl..h..pht..ppp.pht.p..ps............pst..lF+RaLp+hL.-ht+hGhspt............YDsplhhphp.h.El.thlttt.t.hp..uslspuls..ph..Lh...ph+.ps....ptWpWpFEs.Fsl.-..shhhlh...lslLhlVhll.s..TplaohltW....ahQ.lpRl.hhlsFlhShhWNWhaLYKhAaAp+...pspl...s..Kh.t..hsp.Cs..cc.hsW....tslh..-ahptth.Th..ps.DsCpcYaEhLlVsPhh.VsP.oKALulThTsFlsEPL.KalGpGhuEFlcuLh+-lPh.hhp.lP.VLl...h..hslsl.lshhahss.th.......................................................................................................................................................................................................................................................................................................................................................................................	0	10	12	25
+5763	PF05935	Arylsulfotrans		Arylsulfotransferase (ASST)	Moxon SJ	anon	Pfam-B_3266 (release 9.0)	Family	This family consists of several bacterial Arylsulfotransferase proteins. Arylsulfotransferase (ASST) transfers a sulfate group from phenolic sulfate esters to a phenolic acceptor substrate [1]. 	24.20	24.20	24.60	24.40	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.83	0.70	-5.99	33	999	2012-10-05 17:30:42	2003-05-21 09:52:45	6	8	517	6	144	1072	349	451.30	30	83.36	CHANGED	hlhlNPY...ssuPLoAllthsspphsslploVpsK.tpsuhsIsasss....ppthps+s..........lPVhGLYscatNpVplphsp..sGcs...hpcshplpssslssthsst..........pspshK.sssthtspLYhlss..................................s.pshsahlDspG-lRWahs.sthhstt............hcphpsGphhhsps...........pp.hhchDhhG+..hlpp.tcLsssa.............shpH-hhphsN.......GNhLltsup.p.h......s.......psscolcDhllElD.psGpllchWDlhclL..DPhRs..h...............................ptshsshsGss.su+sWhHlNultYDtpDDSlIlSuRHQsullKIs.....cspclpWIluspc..GWscp.......h.pphlLpPlct.G..h...............pusFcasasQHsshhlss....p.....lhlFDNGssRuhppsshs..............c..YSRuVcY+IDppshTVpQlWpYGKp+.G.chYSslsSss..-ahsc.sshhlhSusssh.............t.tt.........................lsEhchps...pcsth-hphpss.t.........sYR	.......................................................................................................................................................................................h.l.hsPY..s.sPLoAhl....ts...h.ts.lplplhsp...tps..ltaphs.......h..sa...........lPlhG..........Lh.ph.Nplplphtp....uph......p.th...h.sssh..........................phps.p.sssthpstL.Yhhsp..................................t.hsshshhhDppGp..h..R..aa.h.s..sth.h.s.........................hp.p...h....p.G.t..hh.h.sts..........................pc.h.h.c..aD.h.h..Gp.....hlhp......hcL..s..pta....................................................p.h..p.Hs.h...pt.s.N...............G.s..hllt.s...u..p....shhp.........s.............................hphpT.lc.....D.t.I.l.....E.V.......D..p....s....G.....p..lV.c.....W...c.hh.clL......DshRs.s.hh....................................................................pp.hu..s..h...sG...su...ss+sW..hHlNSl.......s.......Y..........D...s......p......D...............D............u..IIlSuRHQsullpIs..........csp.pl.+..WIL.u..ssp...uW..ptt........h....tth..lLpPVctpG..l........th............tps..sFcaoa.sQHsuahlspt...............h.lhsF.DNG.ssR..uh..-p.Ps..h.s........................................hp..YSR..hVp.....Y...p...I....D.p..p..p..h..TV......p...plW.....p........Y...G........K..-........c....G................c.......a..Y...S.s.hsSss...ch.ss...sshhhatushs.h...............tp...s....................hlpEhp.tp.ppshhEhph.us....................................................................................................................................................	0	48	86	119
+5764	PF05936	DUF876		Bacterial protein of unknown function (DUF876)	Moxon SJ	anon	Pfam-B_3279 (release 9.0)	Family	This family consists of a series of hypothetical bacterial sequences of unknown function.	19.60	19.60	20.00	20.10	19.20	19.50	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.11	0.70	-6.03	124	1520	2009-01-15 18:05:59	2003-05-21 09:55:25	7	6	940	0	277	1100	65	410.80	30	94.64	CHANGED	HFQQQ-Rah-thhctpspshssas..WGhppLp.lDpphLshG+lslppspGlhPDG.Thashstss.sh.PssLslss........................sstspl.VaLAL.Pltpssssp.ss.spt..............ssssRa..tspttcltDtpssssp.......................tplpluphslc...Lhhpp-..spssa...sslslARlhc..ps-GslhL.Dps.FlPPhLshtu.sshLtphlpclhshlptRucsLutRh.ssssp.s..usu-lscFhh...LpslNchtPhlpHl.hptsplHPEpLYppLhplsGcLsTFo........ps+psss.hPsYpHcshtssF.ssLhptLRphLssV..lpppshslsLp.pp...phuhhhuhlpDsplh.p..supFlLuV.+Ashssc.pLpppFs...ppsKlGus-clcpLVs.pLPGlsLpsLsssPp.plPh+sGhtYFpL.-.psushWpph.tpuuuhAlalsuph..s.sLcl-laAl+	....................................HFQQQpRah-ahhppphpshs.sa...WGhsplp.lsp-hLs.G+ltlppspGlhPDG.ThFsh...Psps..sL.Psslslps........................sptssh.laLAl.Plhpssttp.hs.spp..................pthuRa..p.ptt-l..pDhputtts........................tslpluphpl+...Lhhpp-.......sps..u.a...hslPls.Rlhch...pss...GsltL.Dcs.FIPPhlshpu..ush............L.....t.ph...lpclhshlptRupsLupRh..ss.ssp.t......usA-Vu-Fhl...LphLNRhpshlpHh.tp.hstlHPEpLYppLspLsG-LhTFo..........s+tsss.hssYpHcs.tssF.psLhstl+phLssV..L.spslslsLp...ph...p.uhhhAslp.-spLh..ppusalLAV.+AshPs-.pLpppFs...tpsKluus-clcpLVsspLPGlsLpsLsssPp.plPa+sGhpYFpL..D..pputhWpph.tpuuuhAh+luGsFs..sLphpLWAl+..............................................................................	0	46	113	193
+5765	PF05937	EB1_binding		EB-1 Binding Domain	Yeats C	anon	Yeats C	Family	This region at the C-terminus of the APC proteins binds the microtubule-associating protein EB-1 [1]. At the C-terminus of the alignment is also a Pfam:PF00595 binding domain. A short motif in the middle of the region appears to be found in the APC2  proteins (e.g Swiss:O95996).	25.00	25.00	53.00	53.00	19.50	21.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.20	0.71	-3.89	2	49	2009-01-15 18:05:59	2003-05-21 10:46:52	6	13	34	8	26	49	0	167.40	79	6.09	CHANGED	RSGRSPTGNoPPVIDsV.-pup.p.csuKDsps+pNsGNGsVPh....LENR.pSFIpVDu.DpKGT-.Ksh.NN....pETNEsolsERTsFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSsu-soouRPSQIPTPVsNsTKKRDSKT-oT-SSGoQSPKRHSGSYLVTSV	.........................RSGRSPTGNTPPVIDSVSEKGNsshKDS...KDNQuKQN.VGNGS..sPhRThGLENRLNSFIQVDuPDQKGTEsKPGQ.sNPVPsuETsESSlsERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDoTESSGTQSPKRHSGSYLVTSV.......	0	1	4	10
+5766	PF05938	Self-incomp_S1		Plant self-incompatibility protein S1	Moxon SJ	anon	Pfam-B_3292 (release 9.0)	Family	This family consists of a series of plant proteins which are related to the Papaver rhoeas S1 self-incompatibility protein. Self incompatibility (SI) is the single most important outbreeding device found in angiosperms and is a mechanism that regulates the acceptance or rejection of pollen. S1 is known to exhibit specific pollen-inhibitory properties [1].	21.10	21.10	21.20	21.10	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.90	0.72	-3.95	45	443	2009-01-15 18:05:59	2003-05-21 10:49:09	6	15	25	0	271	427	0	103.40	25	60.77	CHANGED	spVhIhNcL....s.....ssps.Lt..lHCpSp..-cDLGhchlps....sppasapF.....css..hh.tsThFhCphph....sstt.ptpFclYpsppc.t........tp.shWps+c...DGhahhppthsh................phphsWp	..........................h.tlhlhNph.....s.....ssps...lp..lHCpSp..-.c.D...LG.p...h...lt.......upph.p.a.pF.......c.s....hh..tsThF.h...Cshpa.......st...........hphpFcsapsp.c.-.ttt.............tp.ChWplpc....-G....lYhhppp.t.t..........................................................	0	78	141	181
+5767	PF05939	Phage_min_tail		Phage minor tail protein	Moxon SJ	anon	Pfam-B_3296 (release 9.0)	Family	This family consists of a series of phage minor tail proteins and related sequences from several bacterial species.	21.10	21.10	21.20	22.10	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.41	0.72	-4.10	33	1252	2009-01-15 18:05:59	2003-05-21 10:57:39	8	7	595	0	60	582	108	107.20	47	95.89	CHANGED	hETFsW..pspsss.ssssp.pV+pspFGDGYpQpsusGlNscppsasloasGscsphts.....lpsFLcRHuGs+uFhWTPPhsshslah..ssphpssshuushhsloATF-QsFp	...............hcTF+W..cl+ssM..pVsopPsVppV+FGDGYpQRtssGL..NspL..+TYs.V.T.hp....V.s+.p-.sps.......L-uFLscH.G.G.h+AFLWTP.P.a.s.h+p.l+V....sC..t..p..W..Ss....p......s.uh....hh.s..phoApFEQVV..............................	1	5	23	41
+5768	PF05940	NnrS		NnrS protein	Moxon SJ	anon	Pfam-B_3395 (release 9.0)	Family	This family consists of several bacterial NnrS like proteins. NnrS is a putative heme-Cu protein (NnrS) and a member of the short-chain dehydrogenase family [1]. Expression of nnrS is dependent on the transcriptional regulator NnrR, which also regulates expression of genes required for the reduction of nitrite to nitrous oxide, including nirK and nor. NnrS is a haem- and copper-containing membrane protein. Genes encoding putative orthologues of NnrS are sometimes but not always found in bacteria encoding nitrite and/or nitric oxide reductase [2].	23.50	23.50	31.80	26.30	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.47	0.70	-5.56	122	829	2009-09-11 14:42:48	2003-05-21 11:06:32	7	3	628	0	253	740	124	369.60	30	94.48	CHANGED	t.s...lhp.hGFRPFFLhuulauslulsl..Wlhh...h.sGths.hs........hsslhWHsHEMLFGFusAllsGFLLTAlts.WTGp.slpGtsLh.......sLhsLWLsuRlsh.hhs..........hshhlshhlDhuFlshhuhhlu+.lhpu.+p.....hRNlhhlshLhlhshsNhhha.....hthh.tts.shtttshpsulhhlshllsl..lGGR............lIPhFTpshlt........sttst....shs.h.l-tsslhsshhshht.....hhhs...shl.suslhhsAuslphlRhh+.WpshtshppP.LLahLHluYhalslGhhlhu....huhh........shs.shusulHslslGulGshlLAMhoRsoLGHTGRs..L.tssts.hshuashlhhAAlhRlhsshhh...shhhhhltluushWshAFulashpYsPh..Lh....pPRh	..........................h..slhp.hGFRPFFLhuulaAslulhl..Wlhh.....h..sGth.s...h.........hsslhWHsHEMlFGFusAllsGFLLTAlts.WTGh.ss..spG.tsLs.......sLsslWLsuRlhh..hhs......................hs...hhl..ss...hl...-...shFhh..hhuhhh....up..ll.t.u.+s........hRNh..h...hlshlhhhsh.ss.hhha.....hthh....tts.h..h.....htshpsul..hh.h..s.lllsl..lGGRllPhFTpptls..........................................t..thh.................shhh...h-thsl.hshlhhhlh..................hhhh..........s.l...suslhhsA...us..h.p.hh.Rlhc.Wpsh.tshpcP..lLhhLHluYhalslGhlhhu..................huth.......s.h...s.ssulHhhslGulGshhLuhhsRsuLGH.TG.Rs...l...hss.s..hthAahhlhhAAllRshushh......shh....hhhltluuslWshAFslashpYsPhLhpsR............	0	68	149	209
+5769	PF05941	Chordopox_A20R		Chordopoxvirus A20R protein	Moxon SJ	anon	Pfam-B_3744 (release 9.0)	Family	This family consists of several Chordopoxvirus A20R proteins. The A20R protein is required for DNA replication, is associated with the processive form of the viral DNA polymerase, and directly interacts with the viral proteins encoded by the D4R, D5R, and H5R open reading frames. A20R may contribute to the assembly or stability of the multiprotein DNA replication complex [1].	25.00	25.00	68.10	67.80	17.90	16.50	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.98	0.70	-5.69	12	69	2009-01-15 18:05:59	2003-05-21 11:13:31	8	1	42	0	0	58	0	326.60	57	77.69	CHANGED	MoopsDLppLKELL+L+cslclu-ppsp-+YNuLV-WAopsYW+lulp+lssscsSIscYYpss+scs.FtLcsGcYhFLshpFGssalYh+G.shhELGSG.sthpIscch+shh-tllsc.sDlcFLRFVhF+ppWllEDshSchps.PhshLchAup.Glpsssalplc.lccsshFs--DYsslcphhtsh...csFhhsulChl+-Gs.cRpllDFhphsaspVcsI-LE.lssNhalPplITtsGpplLV+DlpHLlcS+s+hsoFVsV++h+shhlLs-psstss.E.o+uEsLpRIlcph.Gs-aFlN.GpYlSKl.sshslpplos+.LGl.hsCssl-	...MTS.SuDLoNLKELLsLYKSL+FSDuAAlEKYNSLVEWuTsTYWKIGV..pKVAslETSISDYY-ElKN...KP.FsI-PGhYIFLPlYFGoVFIYSKG.NMhELGSG.NohpIPD-hRSACsKVLcusssI-FLRFVLhN.NRWIhEDAlSKYpS.PVNIFKlASEYGLNlspYLcI-.IEEDTlFs-EhYulIE+uFc.....DpF.thSIsYIKhG-h+RpVVDFFKaSFMYIESIKl-+IG......DNlFIPolITKSGKKILVKDVDHLIRSKVREcoFVpVKKKNoFoILhDhsGsGo.E.TRuEVI+RII-.oI.GRDYYVN.GKYhSKV.GsAuLKQLoNK.LsI.s-CsTV-.....	0	0	0	0
+5770	PF05942	PaREP1		Archaeal PaREP1/PaREP8 family	Moxon SJ, Bateman A	anon	Pfam-B_2248 (release 9.0) & Pfam-B_9342 (release 9.0)	Family	This family consists of several archaeal PaREP1 and PaREP8 proteins the function of this family is unknown.	21.00	21.00	21.00	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.45	0.71	-4.22	116	500	2012-10-01 22:14:54	2003-05-21 11:19:01	6	1	40	3	319	475	0	112.80	25	72.44	CHANGED	s+LctAhh.hc.AtchLccG.htpAutKhapAhcthlpAlAtt.....h...hptcpphtttt.................hhptlsplhpphs.pplhhhhshAhs.LHtht..hh-sp..hshschpsppcshccll	.............................hl..Ahh.hp.A.chLc....cG........hhpAutKhapAhcthlpALuht...t.h....hppctch.tpp................................hhptlsplhpc.lG.ttlh.hh.sh...Ahp.LHtht..hh-sphthschppptpshccl...............................................................................	0	102	136	238
+5771	PF05943	DUF877		Protein of unknown function (DUF877)	Moxon SJ	anon	Pfam-B_2566 (release 9.0)	Family	This family consists of a number of uncharacterised bacterial proteins. The function of this family is unknown.	19.40	19.40	19.70	20.00	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.21	0.70	-5.99	95	1739	2009-01-15 18:05:59	2003-05-21 11:22:27	7	7	993	0	325	1173	101	394.70	43	83.71	CHANGED	l-phIup..IDptlSpQ...lstIlHpscFQpLEuuWRGLcaLVppo-...sspslKIclLsloKcELhcDhc..cus-hsQSsLa+plYpp.EaGphGGcPaGsllGDYpFspssp......DlplLppluplAAuAHAPFluuuuPphFGh-sap-L.ssh+DlsplF.-ss-..YspW+uhR-oEDuRYlGLshPRhLhRhPYus.cssPlc...sFsacEp........ss..scccYLWuNAAauhAsplscuFscaGWsspIRGspuG....GtVps..LPsH........hapss.GshphKsPTEltIoDRREtELuc.GFIPLshtKsoDhAsFauupSlp....KPpha.........psppAssNu+LuupLPYlhssoRhAHYLK.VlhR-pIG..Sapp.pp-lEp.LNpWlppYVsssss.ssp-h+A+pPL+pAcVp......VpElsGpPGaYpsshhl+PHaQh-shsssLpLVucLs	......................................pthIAc..lDpplScQlshIlHps-FQplESsWRGLchLVppT-.....hccslKlcl.L..sloKc-Lhc.Dhc..pus..-hsQ.SslaK+lYpp...EYG.p.hGGEPhusllusYtFspos.......DlpLLptlupVuAsAHuPFIuusuPphhth.cSapEL.ss.+DLsplF...-ssc.YspW+uhR-S-DoRYlGLThPRhLhRlPYu....s.cssPVc...sFsatEp.l....................ss.....sHpcYLWuNuAauhAsplscSFtcauWC.stIRGspuG......GsVc..sLPsH........hatot..GtlphKhPTElhIoDRREhELAc.GFIPLshpKsoDhAuFFu.ApSlQ.....KPt.a.............pst-AssNucLu.upLPYlFh..hsRhAHYlKsl.R-pIG..Sa+-.Rp-hEp.LNpWItpYVsspps.ssp-s+u++PLpsAc.V...Vp-.l.cG.p.PGaYpsthhlRPHFQh-GhshsLpLVucLs..............................................	0	64	150	236
+5772	PF05944	Phage_term_smal		Phage small terminase subunit	Moxon SJ	anon	Pfam-B_2645 (release 9.0)	Family	This family consists of several phage small terminase subunit proteins as well as some related bacterial sequences [1].	21.00	21.00	21.50	25.00	20.40	18.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.50	0.71	-4.49	36	711	2009-09-11 11:40:06	2003-05-21 11:27:24	7	4	530	0	70	559	9	130.40	42	55.90	CHANGED	hL.hpLspDpppLKslpShpcKsphKRc.lLPpYhsalpGsL....suGpGtQD-llspshlWtlDsGDhcsALclApYAlcas.LshP.-pFpR.ohsshlA-ElsshAt....pshpsupsh-sthhpp...........sh....clssst..DhPDpl	...............LhpLttDpccLKulpSpptKAthK+E.LL..P..catsWl-GsL............pu....Gt.u.t..Q.D..-.Vlh.plMlWtlDsGDhssAL-IucaAl+as.LsMP.tpapR.sssshlsEElus.sA.....ps.t.t.su...p...s.h...D....s....s....hLhp...................sh.....-lssst..DMPDp.............................	0	8	30	51
+5774	PF05946	TcpA		Toxin-coregulated pilus subunit TcpA	Moxon SJ	anon	Pfam-B_3639 (release 9.0)	Family	This family consists of toxin-coregulated pilus subunit (TcpA) proteins from Vibrio cholerae and related sequences. The major virulence factors of toxigenic Vibrio cholerae are cholera toxin (CT), which is encoded by a lysogenic bacteriophage (CTXPhi), and toxin-coregulated pilus (TCP), an essential colonisation factor which is also the receptor for CTXPhi. The genes for the biosynthesis of TCP are part of a larger genetic element known as the TCP pathogenicity island [1].	25.00	25.00	66.60	65.80	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.70	0.71	-4.26	14	136	2012-10-03 10:38:27	2003-05-21 12:21:49	7	3	59	7	5	90	0	125.20	64	58.82	CHANGED	uuLVsLGKlSsDEA+NPFoGsshsIhuh.cNuAu....NKuFAIpVsGLTQsQC+oLlTsVGDhFsYVsVpsuuusAhutLsDFtss.usAs.sGsGllKSlussupsLsLs-I.HlppLCp....ssusFuVshG	.sGLVSLGKlSADEAKNPFTGTsMsIFSFPRNuAA.....NKAFAIoVsGLTQAQCKTLVTSVGDMFPaIsVKpuAh.sAlADLuDFETosAsAA.....TGsGVIKSIAPuSsNLNLTsITHVEpLCs....GTusFoVAFG........	0	1	3	5
+5775	PF05947	DUF879		Bacterial protein of unknown function (DUF879)	Moxon SJ	anon	Pfam-B_3751 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	29.80	29.70	23.10	21.80	hmmbuild  -o /dev/null HMM SEED	602	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.70	0.70	-6.16	134	1615	2009-01-15 18:05:59	2003-05-21 12:25:26	7	4	942	0	303	1242	93	573.10	31	98.90	CHANGED	lLcYYpcELsaLRchutEFAppaPclAscLuhpt...spssDPaVERLlEGFAFLsARlppKLD--aPchTcuLLphLaPpYLpPlPShollphpPs.s...tlspuhplsRGotlpopssp.............tst....................CcFRTsp-lsLhPlplspuph....psssts...................puslclpL.....pssss..shupLs...........lcpLplaLsG.spthutpLachLhppshshhlp.sssp..............hsL.ssss...lp.sGFss--uLL..Phst.psFpGaRLLpEYFshP-+FhFhclsGL.......t..htts.........pphclhlhl.....tppsst.httplsspphpLaCoPllNLFp...ppu-PlplstppsE.Yhlhs.cpppstshElaSlcpVpuhpps..............tppp...............ah..Paauhpc...ttttst..pst.Yaph..RRcsphhsp..p.............salollcts........tpshp.......sh.ctLolclh.CTNRcLPpp.Lsh......sphshshtpu.ssstslpslpsPotPhts....hss.............phtWRLlSpLuLNaLSLh..........pusps.L+plLpLYshp.......ssstspcpl-ulhslpscssschls.....sshsRGlclpLslDpssF..sssshaLFusVLc+FauhasolNoFspLplhspppsc.hhpWssphGppsll	.............................cYYpcELsaLRch.ut-FAptaP+lAthLuht.....tps.sDP.VERLlEuFAFLouRlppKlD--aPEhTcuLlphLaPpYLpPhPSh...ullphpPchp.....phspshh.lsRsotltopsst.............tst........................CpFpospDlpLhPlp.lppsph....pssstt.....................puslplph................pstss...hshu.pLs.................LscLphaLsG..-phhsspLathLtpphhshhlp.sssp..................hsL...spth.......lp.hGFss..p-uLL....P.hst...s....s....apG....YpLLpE..YFsaP-+FhFhclsGl.............................sthhtth..tspthplhlhh.......p.p.sh.hthplstsphpLaCsPlINLF....+cu...-...slplstp.psE.Y.lhs.sp.p.p.s...t.caE.laSVspVhuhpps..............sspp....................a.PF.uhp+...psthst.....pst..Yaph...R..pcpphhspthp.......................phalullcts..........tssh.........stcslSlpl.h.CTNRcL.Ppp.lt.......sshshshpss..ssstshpslptPotPhhP....hcs.............phtW+LlSpLu...hNaLoLh........................tssps.L+phLt.lasht.............psphspp..pl-....ulhplcppsls+hhs.............s.....hhsRGlphpLsl-ppsF...stsshaLFGpVLp+FhuhYsulNoFsplslhstpptc.hhpWs.+hGpp..................................................	0	46	112	205
+5777	PF05949	DUF881		Bacterial protein of unknown function (DUF881)	Moxon SJ	anon	Pfam-B_4053 (release 9.0)	Family	This family consists of a series of hypothetical bacterial proteins. One of the family members Swiss:Q45543 from Bacillus subtilis is thought to be involved in cell division and sporulation [1].	25.00	25.00	25.50	25.40	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.64	0.71	-4.75	103	1279	2012-10-02 00:20:33	2003-05-21 12:37:39	7	1	506	2	348	917	13	150.00	28	57.10	CHANGED	ppclcphphhuGhssVpGPGlplTlsDsstt.............s.s.hhlpsp-.lhpllN-LhsuGAEAIuINs.........pRlsssotIcss..Gs..slhlss.phhss....P..asIpAIG-....sssL.psuls.sushhphhpth......ulplplpppc......plpl.suhsss....phpaAcss	................p..phpphthhuGhssVpGPGlplTlsDssts.................................t.s..hl.pspD..lhpllNpLhsuGAEAlsINs.....................pR.lsssotl+ss....Gs..slhlss.psh.u.s....P...YsIpAIG.c....spsL.psuls.....s..u..s...h.lpthcph......Gls.hp.lppp.c......plsl.suhsss..thpaAp..................	0	139	265	314
+5778	PF05950	Orthopox_A36R		Orthopoxvirus A36R protein	Moxon SJ	anon	Pfam-B_4070 (release 9.0)	Family	This family consists of several Orthopoxvirus A36R proteins. The A36R protein is predicted to be a type Ib membrane protein [1].	25.00	25.00	34.90	34.90	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.06	0.71	-4.30	3	57	2009-01-15 18:05:59	2003-05-21 12:45:40	6	1	22	0	0	43	0	129.00	92	68.68	CHANGED	MMLVPLITVTVVAGTILVCYILYICRKKIRTVYNDNKIIMTKLKKIKSSNSSKSSKSTDSESDWEDHCSAMEQNNDVDNISRNEILDDDSFAGSLIWDNESNVMAPSTEHIYDSVAGSTLLINNDRNEQTIYQNTTVVIN-TETVEVLNEDTKQNPNY	..MhLVPLITVTVVAGTILVCYILYICRKKIRTVYNDNKIIMTKLKKIKSS..NSSK.SSKSTDsESDWEDHCSAMEQNNDVDNISRNEILDDDSFAGSLIWDNESNVhAP..STEHIYDSVAGSTLLINNDRNEQTIYQNTTVVINE.TETlEVLNEDTKQNPSY.....	0	0	0	0
+5779	PF05951	Peptidase_M15_2	DUF882; 	Bacterial protein of unknown function (DUF882)	Moxon SJ	anon	Pfam-B_4115 (release 9.0)	Family	This family consists of a series of hypothetical bacterial proteins of unknown function.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-4.78	10	1137	2012-10-02 01:02:30	2003-05-21 12:54:22	8	4	1078	0	236	840	393	149.00	54	64.95	CHANGED	puuucsRsL+LaplHTGEKsEhsYhcsG+YspcuLp+ls+lLRDaRRNEss+MDPRLFDLlaplhppoGocsh.IpVVSGYRSPATNuhLRoRS+GVAKKS.HMlG+AMDFaIPGVsLK+LR-sulchQsGGVGYYPpSGSsFVHhDVGsVRpW	.....................................................hu.oscPRhLsLpNL.H.TGEsl.c.sc.Fa.c.G.c.s.Ylp-pLs+L..NHFhRDaR...s.N...cl.+sI.DPt.L...FDpLa..c....l...Q...s...hL...G..o..+...c...P.....lplI...SGYR..S.sTNsp.LR..u.+.....S...+..GVAK..+SYHh...+G..Q..AMDF..+I...............-..G......l..s........Lup....l.Rc..A......A..L......u...h....+..AG...G..V...G..Y......Y..PR..S....N...............FVHIDT.....G.PsRpW.....................................	0	56	120	171
+5780	PF05952	ComX		Bacillus competence pheromone ComX	Moxon SJ	anon	Pfam-B_4222 (release 9.0)	Family	Natural genetic competence in Bacillus subtilis is controlled by quorum-sensing (QS). The ComP- ComA two-component system detects the signalling molecule ComX, and this signal is transduced by a conserved phosphotransfer mechanism. ComX is synthesised as an inactive precursor and is then cleaved and modified by ComQ before export to the extracellular environment [1].	19.80	19.80	19.80	20.50	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.60	0.72	-4.46	11	61	2009-09-11 08:33:53	2003-05-21 13:51:57	7	1	39	0	11	48	0	54.90	33	97.18	CHANGED	M......Q-llsYLlcNPEVLcKltsG-AoLlGlsscpspsIlcuFpch.hhotts.h.W.s................t	......M...Q-llsYLlcNP-VlcclppGcASLlGlscc...phpuIlcuFpphphhp.hp...W...p.............	1	5	7	8
+5781	PF05953	Allatostatin		Allatostatin	Moxon SJ	anon	Pfam-B_4313 (release 9.0)	Repeat	This family consists of allatostatins, bombystatins, helicostatins, cydiastatins and schistostatin from several insect species. Allatostatins (ASTs) of the Tyr/Phe-Xaa-Phe-Gly Leu/Ile-NH2 family are a group of insect neuropeptides that inhibit juvenile hormone biosynthesis by the corpora allata [1].	33.50	2.10	36.40	2.50	26.90	2.00	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.30	0.74	-5.77	0.74	-2.90	21	453	2012-10-01 21:03:17	2003-05-21 14:00:26	7	15	40	0	100	478	0	11.20	60	36.41	CHANGED	KRssp..YuFGLG	.........KRst.......YuFGLG.	0	52	66	88
+5782	PF05954	Phage_GPD		Phage late control gene D protein (GPD)	Moxon SJ	anon	Pfam-B_4333 (release 9.0) & Pfam-B_12199 (release 10.0)	Family	This family includes a number of phage late control gene D proteins and related bacterial sequences.  This family also includes Bacteriophage Mu P proteins and related sequences.	23.50	23.50	23.70	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.12	0.70	-5.22	283	5310	2012-10-01 22:58:23	2003-05-21 14:04:18	6	63	1555	10	1086	5029	137	285.80	18	48.10	CHANGED	pc.uls.p.hphplsh...h...................sssslthtt...hlGpslslpl..................................t.....hpGhl.................sph......t..............hus...cts.........Y...plslpshhthl........shp.p.cs+h.......a...ps.polscIlpplhs...............htLpt...t......hshhs.........assQap.EoDhsFlpRLhccpGlhah..hpp.tt...............p..pLllsDss.ss.....h............stsl.hhttsssss......tpslppap.htpphtsspspspsash...cpsptt.................h...t.............................................ss..hph..hpa.....................sst....................spup...phAch+h..-thpspspphpu..tussps.........l.tsGthhplsst............ts.hsp.......pallhplpaphp..ssh	.................................................................................................tthp.p.hphplph..h...........t..........pt.sh.htt.......hhsp.hplpl..................................................................p...hpGhl.....................sth......p..........hsp................stt.......hh........a......plpl....ps..h..h..hhh.............shp...p..sp+h...................................a........ps....p...o....l.....pIlpplhp.............................p....htlpt....p................h..t.hc...............a...ss.Q...at...Eo..DhsFlp.RLh.....tc......t.........Glhhh..hcp..t......................p.pLlhscss..ps....................................sttl.shh.s...sttps....................shp.php...ht..t..p.......h..t.s.s...p...lt..hps.ash.......cpspht...........................................................h...t.......t..p...................tts..hth......hpa.........................tsp.............................tpup..thu.p..h.ph......-thppts..........t..phpu...........tu.st.t..............l..hsGthhplps...................psthsp.....pahlspspaphp.p..t...................................................................................................................................................	0	223	517	791
+5783	PF05955	Herpes_gp2	Eq_herpes_Gp2; 	Equine herpesvirus glycoprotein gp2	Moxon SJ	anon	Pfam-B_4360 (release 9.0)	Family	This family consists of a number of glycoprotein gp2 sequences from equine herpesviruses.	25.00	25.00	318.80	318.00	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.61	0.70	-5.02	5	19	2009-01-15 18:05:59	2003-05-21 14:10:55	6	1	9	0	0	20	0	226.70	69	33.06	CHANGED	KNFMEASCTVET..NSGLAIFWKIGKASVDAFNRGTTHT....RLMRNGVPVYALVSTLRlPWlNVIPLTKITCAACPTNLluGDGsDLNSCToKSTTIPCPGQQRTHIFFSAKGDRAVCITSELVSsPTITWSVGSDRLRNDGFTQTWYGIQPG.VCGILRSEVRIsRssWRhGtso+DYLCElsASD..AKTSDYKVLPNAH...STSNFALVAATTLTVTILCLLCCLYCMLTRPRASV	KNFhcAoCTVET..N.GLuhFWKIGNASVDAFsRGTTHT....RlMRNGVPVYALVSTL+lPWlNVIPLTcITCAACsoNhltGstsDLsSCTsKSTTIPCPGQQRTHIFFStKGDRAVCITSELsS.PTITWSVGSsRL+NsGFoQTWYtIQPG.VCGILRSEV+IpRsoWRhGuso+DYLCElosSD..uKTSDYKVLPNAa...STSNFALVAATTLTVTILCLLCCLYCMLTRPRASV.......	0	0	0	0
+5784	PF05956	APC_basic		APC basic domain	Yeats C	anon	Yeats C	Motif	This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged  amino acids and interacts with microtubules [1].	25.00	25.00	71.10	38.20	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.47	0.70	-5.32	4	93	2009-01-15 18:05:59	2003-05-21 15:32:18	6	35	37	0	46	80	0	308.10	51	13.43	CHANGED	slhRGRTVIYsPustspsps.......soP.pKpuPPspspsusssKsPS.uQpRS+SLHRsuK.SphusLS.PsRSuTPPuRhuKoPSSSSSQTSssSpPh.p.pshsTpsuG...slPG.....PusuL..VP..pSPuRshhA.........pp+KTQ+SPVRIPFMQpss+..PsPLu.....pshsEPusRGhsthpussGA.uu+LtLlRMuSshSSGSE.SDRSG...FhRQhTFIKESPu.hLRR+RsEhSSh-StusospsASPpRupsthPAVFLCSSRCpEL+su..............PcQu.s.t...pQppPtuRss.u.h......ssRRToSESPSRLPl.Russu+.........sETsKRaASLP+ISlhRRssSusSlhouSu-	...............ul.RGRThIalPuspspopS.......ToP.pKpuPPh+s...s.u.....KsPS.uQptopS..RsuKsS.p.u-LS.ssRpso....ut.sKu.PSp..SuSpsSTPS+Ph.p.hspshQos...G.sph.PG.....Pssp.l.op...lP.ssS.PupAspp......ppsps+ho.pSPsR....Qs.sK...ssLu..so...shspsEsuS+G.hsthpsusGu.sp+lpLsRMoSs+SSGSE.SDRSt...hlRQ.TFIKEuPo.hLRR+hpE.uS..hE...S.husoops.sSPpRupsthPsl...Ssphs-hphu..............Pp.sss.....tptpPttRts.hu...........RopSESPSRLPl.Russh+..........EpsK+.uSLP+lSshRRssSuoSlhoAsu-...............................................................	0	2	7	18
+5785	PF05957	DUF883		Bacterial protein of unknown function (DUF883)	Moxon SJ	anon	Pfam-B_4421 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	40.00	40.00	40.00	40.00	39.80	39.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.97	0.72	-3.59	59	2283	2012-10-02 00:15:32	2003-05-21 16:01:49	8	2	1022	0	347	911	46	93.30	38	87.31	CHANGED	cplts-l.cpLhsshEcLLcpsustuspphppLRp+hpptLcps+splssstcs....stc+u+puscss-cY.......V+-pPWpulGluAu.lGhllGlLlu..RR	...........................t.clps-l.ppLs-oLE-VLcS.s....Gsp...ucpc....hpcl....Ru.+A....c....p.sL....ccs+tRls....psscs.......ltppu....+pAsspADcY...........V....+EcPWpu....lGlu.A.A.VGlllGlLLuRR......	0	46	135	243
+5786	PF05958	tRNA_U5-meth_tr		tRNA (Uracil-5-)-methyltransferase	Moxon SJ	anon	Pfam-B_4661 (release 9.0)	Family	This family consists of (Uracil-5-)-methyltransferases EC:2.1.1.35 from bacteria, archaea and eukaryotes. A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalysed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. It is thought that tRNA modification enzymes might have a role in tRNA maturation not necessarily linked to their known catalytic activity [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.10	0.70	-5.76	9	7304	2012-10-10 17:06:42	2003-05-21 16:10:13	6	37	4224	7	1556	6444	1014	275.40	29	64.81	CHANGED	sYstQLp-Khs+LpshhAPFpuP-.EVFcSPspHYRMRAEFRlWHE..s--haYhMF-QtsK....p+lRl-pFPhASphINcLMstLlssh+ssssL++KLFQV-FLoTLSG-hlloLLYH+pLD-pWcpsApsLps.....thslslIGRu+tpKIslcpDYVsEpLsVsGRpahYRQlEsuFTQPNusVNpKMLEWAh-sspsppG.DLLELYCGNGNFoLALAppFc+VLATEIuKsSVsAAQaNIstNslDNlpIlRhSAEEFTpAhsthRpFpRL+..GIDLcSYphsTIFVDPPRAGlDs-ThcLVptY-RILYISCNPETLppNLppLpcTH+loRhALFDQFPYTHHMEsGVLLp++	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..............p.................s.............s.........p.........u.FhQ...s..N...s........t.........s....p.......p.....h....h....p....h....A....h....c......h.........h.............p.......h...........p...............t..........p.......c................l.....l......DhaCGh...Gs..h..u....L.....l.................A..................p.....p....s............p..................p........V..h...G..l.......El...s.p..u..ltsA..p..t..NA.......t.h.N...s...l...s....N...s....p.....a..h...t...h.t..u....p.p..h.h.......t.h.......t...............................................................t.....-.s..l...l..l.DPPR.sG..........h.s...p.......p.......h...h.....c.......h........l..........t..............p........h......p..........+......I...l.YlSCNP..s.T.L.A......R...D.................l..........p...............h.....L..............s..............p..........s..............Y............c............l........p........c...l......t.....................h........DhFPpTsHlE..s.lslLp+.h...........................................................................	0	504	946	1296
+5787	PF05959	DUF884		Nucleopolyhedrovirus protein of unknown function (DUF884)	Moxon SJ	anon	Pfam-B_4679 (release 9.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of unknown function.	25.00	25.00	134.90	134.60	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.19	0.71	-4.98	27	58	2009-09-11 07:37:26	2003-05-21 16:12:33	6	1	54	0	0	55	0	184.70	33	92.00	CHANGED	MslpLYpspsp...-s.loFphspshNSlhhahFphtss.ssssp............TRLVSGYEps+....sIshphsssss..............csuYllSChRsPplhhcLh..pp.astslshsVV+..spsp.............splWHVluV+KspEstph.p+lpulpVps...u.-ph..asKpLltlsGNlPusFlpuLsp.shsstp-lcslplhtPplpl	.MslpLYpspsp...-s.IoFphssshNSlslahFphtsssssssp..............TRLVSGYEsu+....sIshphsssss..............csuYllSClRhPhlhpcLh..pp.aopPluhllV+..spsp.............splWHVluVRKspEhtss.p+lpulhssp..sG.-ph..asK-LlhlsGNlPusFlsuLp+.shsshp-lcslplhhPplpl.......	0	0	0	0
+5788	PF05960	DUF885		Bacterial protein of unknown function (DUF885)	Moxon SJ	anon	Pfam-B_4405 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins several of which are putative membrane proteins.	22.10	22.10	22.10	22.30	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.00	0.70	-5.35	150	1292	2009-01-15 18:05:59	2003-05-21 16:37:19	6	10	669	6	493	1292	1570	510.40	24	89.45	CHANGED	sP.hs.ohhGht.tt...........tphs....D..h.Sspshppphpthpphltp..........................L.pslchs....sLsspsplshplhph..hppthtthpap...............t.hslspht..........uhhstl.shh.st.p.hp.........shp-..............................................hcsalsRLpshsphhsp.hhpphcts..htpGhh.P...chhhctslsph.........................................pshls................tshp.......ps.hhsshtph.t............thstpppsplttpsppslppplhPAhpph....hsahp..sphhsss...........pstGhhphP..........................sGcthYpht...lcthTT.o.chos--lHplGlpEVsRlpuEMctl.hpph.....Gh...p........s.....................sltchhphLps-....pah..p.........................s...t..ppllsphpthhpp............hp.stls.chF...t..plPc.sshtVchlss.......hhpsssss.uhYts.ss....Dss...pPGhaalNh.hs..........hpphspasht....sLshHEuhPGHHhQluhspEh.ts.lPthRph..s.....hh.o.AasEGWALYuEp.Lu.cEh.GhY.p.....cP......................................................hsc.................hGpLp.hchaRAsRLVVDTGlH..sc...............tWoR-p..............................................................................................................Alsahtcso.shsp..................................................................................................ssspsEl...-RYhs.h..PGQAhuYKlGtlcIhcL.RpcAc...ppL...Gcc...FD.......l+pFH-hlLppGulPLslL-ppl...ppal	.......................................................................................................................................................................G.tt.ts...........phs-..h.Sstshptphthhpphltp..........................L..pths.s........tL.s.s..p.pp..lshp.lhp....t..ph..p...thp.ttpht..............................hslstht.............uhhtt..l....th..h..s.....hshp..............s.pc.........................................................................................................................hp.shhtRLps.lsthhsp..hhtp..hcts....httGhh.s......phhhpth.ltph...........................................................................................pshhs..............t..............tshhh.sshtph.s.............hststp..splptph.tpslttthhsAapph................hsalpsphhsts...........pp.uh..ph.s..........................sGcphYphh...l+thss.s.sh.ss.........c-la.p.hGhpEltRlps-hppl.tcpl........sh......t...........s...................................shtphhphLcs...-....th........................................................tt......ptlhp.hp..t.hhcc................hp.stls..phF......plPc..t.h.lc.l.s..........hh.t..sstss..uh...Yhs...ss.....Dts.....cPG...hhahss...s..............hpphs.pa..p....h...........shshHEuhPGHHhQhuhstph..ts.lstaR+h..s............hh.o.uasEGWALYu.....Et.Lh.p-h..Ghh.p......DP.............................................................................hpp........................hGhLs.hphhR..AsRlVlDhGlHhp.......................................tWoppp..............................................................................................................Ahsahtpps.shsc.....ss....spsEl.....cRYhs...h....PGQAhuYplGphplhcL...RcpAc...pph...Gsp....FD...............l+tFHstlLp.GulPlslLcptlt.....................................................................................	0	191	354	434
+5789	PF05961	Chordopox_A13L		Chordopoxvirus A13L protein	Moxon SJ	anon	Pfam-B_5061 (release 9.0)	Family	This family consists of A13L proteins from the Chordopoxviruses. A13L or p8 is one of the three most abundant membrane proteins of the intracellular mature Vaccinia virus [1].	24.10	24.10	29.60	35.80	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.37	0.72	-4.04	8	55	2009-01-15 18:05:59	2003-05-22 10:44:54	6	1	35	0	0	40	0	68.40	66	99.31	CHANGED	MIuDllLlIICVsIIGLIVYGIYNKKoosppspPus...EcY.KhEslKTuYVD+LKsuHLsSFYKLF.Sup	MIGILLLIGICVAVTVAILYuhYNKIKNsQNPsPus...lNsPPPEs+N.TKFVNNLEKDHISSLYNLV.SS.u	0	0	0	0
+5790	PF05962	HutD	DUF886;	HutD	Moxon SJ, Rainey P	anon	Pfam-B_5160 (release 9.0)	Family	HutD from Pseudomonas fluorescens SBW25 is a component of the histidine uptake and utilisation operon. HutD is operonic with the well characterised repressor protein HutC. Genetic analysis using transcriptional fusions (lacZ) and deletion mutants shows that hutD is necessary to maintain fitness in environments replete with histidine. Evidence outlined by Zhang & Rainey (2007) suggests that HutD functions as a governor that sets an upper bound on the level of hut operon transcription [1]. The mechanistic basis is unknown, but in silico molecular docking studies based on the crystal structure of PA5104 (HutD from Pseudomonas aeruginosa) show that urocanate (the first breakdown product of histidine) docks with the active site of HutD.	25.00	25.00	30.70	30.60	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.27	0.71	-4.56	106	985	2012-10-10 13:59:34	2003-05-22 10:47:25	6	6	936	6	178	684	43	176.70	33	90.44	CHANGED	lchsch.ssPWKNGGGtTcEIsh.aP.........sGu......shcsFs...WRlSlAslupsGs..FShFsGl-RhlslLpGsGhpLphs...........ut.p....pth..........htPhp.shuFuG-sslsupLhsGs.spDFNlMsRcsthpuplphh....ss..............shph........susssl......lashsG.s....hp.......ls.s...........sphtLpst-sl................hhcs......................ptsl...lpsp....ut.lhhlpl	..............................chpchsss.W+NuuGpT+EIss..a..P..............................sut......c-Ft.....WRhSlAolussGs..FShFPGh-RhlolL-G.sthhL.pss.............................sp...s....cs................LpPhp.PauFuuDtslpucLhsGt.shDFNlMoRhsh.tpuplc..hh......pt.............................................shph...........supssl..........laslsG..s.......hp..lss............................phhh.sspssh....hhcs............pppl......hpst....uthhh...............................................................................	0	33	72	125
+5791	PF05963	Cytomega_US3	Cytomegalo_US3; 	Cytomegalovirus US3 protein	Moxon SJ	anon	Pfam-B_7187 (release 9.0)	Family	US3 of human cytomegalovirus is an endoplasmic reticulum resident transmembrane glycoprotein that binds to major histocompatibility complex class I molecules and prevents their departure. The endoplasmic reticulum retention signal of the US3 protein is contained in the luminal domain of the protein [1].	25.80	25.80	26.10	39.90	20.10	25.70	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.37	0.71	-4.95	3	63	2009-01-15 18:05:59	2003-05-22 10:51:40	6	1	10	4	0	61	0	179.40	54	97.57	CHANGED	MKLVhlLAuLAsLl.LshuDusPRPlssIsS....clTuh.sHFpVEENcC+lHMGplYFRG+lSGNFTc+HF...VsaGIVSpSYhDNLpVouEQaca.cAGsYFEWNVpGtsVsasVDpVDVpLSosWGDPKKWAoCVPQVRsDYoS.shhWYhQhuMhccoWuhhhhsVhhYsLShhhLshhhVhholp.......MRFF	............................MKPVLlLAILAVLh.LRLADSVPRPL-VVVS....EI+S..AHFRVEENQCWFHMGMLaaKGRMSGNFTc+HF...VsVGIVSQSYMDRLQVSGEQYHHDERGAYFEWNIGGaPVsHTVDMVDITLSTRWGDPKKYAACVPQVRhDYoSpoI.WYLQRuMRccsWsLlh..RTllsYhhulslLVLlsVtVSs+.......hRF...............	0	0	0	0
+5792	PF05964	FYRN		F/Y-rich N-terminus	Yeats C	anon	Pfam-B_1170 (release 8.0)	Family	This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00541.	21.00	21.00	21.00	21.50	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.57	0.72	-4.51	45	555	2009-01-15 18:05:59	2003-05-22 10:52:30	9	76	143	1	361	515	8	52.30	35	2.49	CHANGED	huoLtlhsLGpllssp..sFHspphIaPlGYpusRlYhS....hpcspc+shYpCcIh-	...................GulhlpslGpllspp......t..acspptlaPlGYp..soRlYaS....hpcsp.++ChYpCpIh.t................	0	123	177	264
+5793	PF05965	FYRC		F/Y rich C-terminus	Yeats C	anon	Pfam-B_1170 (release 8.0)	Family	This region is normally found in the trithorax/ALL1 family proteins. It is similar to SMART:SM00542.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.72	0.72	-4.17	48	561	2009-01-15 18:05:59	2003-05-22 10:57:39	9	65	144	1	363	525	9	85.00	28	4.25	CHANGED	sspPhFcls.s--......s...hshpusSssssWppllcplpp..h+pppt...........tslsG.-hFGLspsslhpllEsLPsscpCppY...phchtc	.................................................t..tPhFcIp..s--.........s....hshpusSspssWp.pllctlpp.....hRppsp......................hth...tt...lsGtchFGlspsuVhpllEpLPGscpCppY.....pFch.........................	0	122	175	266
+5794	PF05966	Chordopox_A33R		Chordopoxvirus A33R protein	Moxon SJ	anon	Pfam-B_4799 (release 9.0)	Family	This family consists of several Chordopoxvirus A33R proteins. A33R plays a role in promoting Ab-resistant cell-to-cell spread of virus [1] and interacts with A36R to incorporate the protein into the outer membrane of intracellular enveloped virions (IEV) [2].	22.50	22.50	22.50	22.80	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.34	0.71	-5.52	6	66	2012-10-02 16:37:33	2003-05-22 11:01:42	7	1	42	2	1	66	0	170.40	47	96.24	CHANGED	hsspps.Dh.c.s-ptsuFhGSTIYGsKL+.KKphtKKs+sluIsLRIullsSllSLhsIsshLAlQhspCcssp-t.psspulsshs.hosptphstSth.....cpCpGIha-GtCYphssEspo.Fs-AspsCtscuusLPu.ssLhpc.........WlhDYL-GTWG--Gtsl........sKpps.-lpssDlSsEhRsYFCV+Shs	................................................................hhss..........-sc-ppTuhhuuTlYGcKlp.u.Kp...K++RsIulCIRI...ShVISLLSh.ITh.oA.hL.hl.c.L...NpChSss.Eushoctulsssu...u..o.spc.csuuSsop.......................cSC...s.G...LaY.pG.u.CYIhHS-hph.FsDApAsCsscuSoL..Ps..oDllsT.........WLhDYlE-TWGsDGNsI........sKoos...-h...p-uDlSpEsRKYFCVKoh......................	0	1	1	1
+5796	PF05968	Bacillus_PapR		Bacillus PapR protein	Moxon SJ	anon	Pfam-B_4892 (release 9.0)	Family	This family consists of the Bacillus species specific PapR protein. The papR gene belongs to the PlcR regulon and is located 70 bp downstream from plcR. It encodes a 48-amino-acid peptide. Disruption of the papR gene abolishes expression of the PlcR regulon, resulting in a large decrease in haemolysis and virulence in insect larvae. A processed form of PapR activates the PlcR regulon by allowing PlcR to bind to its DNA target. This activating mechanism is strain specific [1].	21.10	21.10	21.20	22.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.20	0.72	-3.90	3	118	2009-09-10 20:50:31	2003-05-22 11:30:16	6	2	101	0	3	32	1	47.80	83	93.33	CHANGED	MKKLLIGSLLTLAMsWGISLGDTALEKsQlISHssQEVQLASDlPFEF	....MKKLLIGSLLTLAMAWGISLGDTALEKSQlISHNDQEVQLAuDlPFEY.	0	0	1	1
+5797	PF05969	PSII_Ycf12	DUF888;	Photosystem II complex subunit Ycf12	Moxon SJ	anon	Pfam-B_4945 (release 9.0)	Family	Ycf12 has been identified as a core subunit in the photosystem II (PSII) complex [1-2].  PsbZ has been shown to be required for the association of PsbK and Ycf12 with PSII [2].	19.60	19.60	19.70	19.70	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.97	0.72	-7.29	0.72	-4.32	40	232	2009-01-15 18:05:59	2003-05-22 11:34:02	6	2	219	13	31	179	2	32.40	54	71.40	CHANGED	M..NhElIsQLssLsLIllAGPlVIsLLuhRpGN.L	......M..NlElluQLssLuLIlluGPlVIsLLAhR+GNL......	1	11	26	31
+5798	PF05970	PIF1	DUF889;	PIF1-like helicase	Moxon SJ	anon	Pfam-B_4988 (release 9.0)	Family	This family includes homologues of the PIF1 helicase, which inhibits telomerase activity and is cell cycle regulated [1][2]. This family includes a large number of largely uncharacterised plant proteins.  This family includes a P-loop motif that is involved in nucleotide binding.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.09	0.70	-5.51	13	2557	2012-10-05 12:31:09	2003-05-22 11:41:20	9	118	754	0	1533	3113	626	193.20	19	32.75	CHANGED	pLssEQ+pla-pIlpulhs.spGthFFVsGaGGTGKTaLWpslhstlRS..cscIVLsVASSGlAuLLL.GGRTAHSRFtIPlshsEtSpC..sI+puoclA-LlpcsuLIlWDEAPMssRpCFEALDRoLRDIlppps....sKPFGGKsVVlGGDFRQILPVlp+GuRspIlsAslssShLWpc.s+.lLpLT+NMRLtssthstpctcclpcFupWlLslGsGclssssstt.......shIplPpDLLlppss.cslcsllsclYsc..llpshss.sahppRAILsPsN-sVsclNsallspLsG-E+pYLSsDols.ssps..c.-hlYPsEFLNSlsssulPsHhL+LKlGsPVMLLRNLs.ohGLCNGTRLhlTpL	..........................................................................................................................................................................................h..h..h........G......uGsGKo....hhhp..............h...............t...........h..........................................h..h.hh....us.o....u.....h.u..u...........h..............t..........G.........................T.h..H....p..h......h.....t......h.................s...........................t......................................................................................................................................................................t.............h............t.....h.p.....hllhDE.....hsMh.....t.....t................h..t....h......l.......p.............h...p.h..................................t...F..G..G..h.......ll..h..GDhhQl........P.............l..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	583	1068	1392
+5799	PF05971	Methyltransf_10	DUF890; 	Protein of unknown function (DUF890)	Moxon SJ	anon	Pfam-B_5064 (release 9.0)	Family	This family consists of several conserved hypothetical proteins from both eukaryotes and prokaryotes. The function of this family is unknown.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.91	0.70	-5.27	4	1276	2012-10-10 17:06:42	2003-05-22 12:58:10	7	11	1113	3	405	2121	363	263.00	45	81.71	CHANGED	tA.psuLHPRNRH+u+Y.DFstLhpssPELcpaVhlNPtGc.SlsFADPhAVKALN+ALLtpaYuVs.WDIP-GaLCPPlPGRADYIHalADLLucusss.hss..thRuLDIGsGANCIYPLlGspEYGWpFlGo-lDs.ulspAptIlpuNspLsstIclR+Q.ppptIFsGlIttsE.pYDhThCNPPFHAShs-AptGopRKhpNLtp.s..........s.s.s.LNFGGQtsELaCEGGEssFlt+MhcESptFApQVhWFooLlSKusNLssLpcpLcplGAsclphhEMAQGQK.SRFlAWoFhs	.............................................................................p...+ssLHPRN+H.ps.cY..Dh.stLsps.P-.L.ppalh.......h....s......s....t..G.........c.S.l........DFusP..AVKtLN+AL.LtcaYuls................WD..IP...t...saLCP.PlP...G..........RADY..IHa.l.....A.....D......L.....L.........u........p.......s.........s......s.......s...lst......................psp.hLDI..G..sGA.NC..I....YP.L.l..........G.s..p.....c..Y........G........W..p..F.s...G.o...................-lsst........ulssAp....tI.l..p..sN...ss......L..sp.t......I..c..l..R....p........Q........p.....p....s...t.........t.................I...F..........s....G.l....l...p...p.....s.....E.......pa...........D...hThC.NPPFH..sS...t...t...t...A.....p...t......G...o...p...R......Khp..s..Lth................................................t......LNF....G.Gpp...p...E.L.W....C-..GGElsFlp+......M.I..pES..t..t........a..t...c..........p...........V..hWFToLlS..+..tp..NL...sslhctL...pc..........h......G......s..s....p.....l....hhhE..M..uQ...G.......Q.K.t.S.RhlAWoFh............................................................................................	0	123	207	320
+5800	PF05972	APC_15aa		APC 15 residue motif	Yeats C	anon	Yeats C	Motif	This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin [1] along with the Pfam:PF05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.	19.40	19.40	20.10	19.50	18.90	19.00	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.92	0.73	-6.36	0.73	-3.62	9	272	2009-01-15 18:05:59	2003-05-22 13:01:02	6	30	58	2	142	273	0	16.00	53	1.96	CHANGED	c.-QPhDYShKYuEcp	.-.DpPhsYSlKYu--p......	0	13	22	62
+5801	PF05973	Gp49	DUF891; 	Phage derived protein Gp49-like (DUF891)	Moxon SJ, Bateman A	anon	Pfam-B_5075 (release 9.0) & Pfam-B_6067 (release 14.0)	Family	This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.	23.90	23.90	23.90	24.00	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.05	0.72	-3.97	226	2071	2012-10-03 00:18:00	2003-05-22 13:01:19	9	4	1184	0	551	1798	191	86.10	24	77.55	CHANGED	calpsL....cp.........ht...sclhtplppl.ptG........hhsshp.....pGlhElRl..chss..saRlhashctsp....hl.llLpuhsKpo...........pp-IchAcphhc	......................................hpth...spp.........ht...tplhhtlphltptG.........shspphp........pslhElRh....phss...hhR.lh.as.hchsp..........hl..llLpuh.pKpo.......p....p.h.pp-IchAcphh......................	0	143	347	476
+5802	PF05974	DUF892		Domain of unknown function (DUF892)	Moxon SJ	anon	Pfam-B_5115 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function.	23.70	23.70	23.70	23.80	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.80	0.71	-4.42	111	1538	2012-10-01 21:25:29	2003-05-22 13:04:39	7	2	728	12	337	830	49	154.30	41	91.00	CHANGED	slc-lalctL+DlYsAEcQhhcsLschuctAps.scL+suhcpHlpETcsQlcRL-plhcth.GtpspuhpCcuhpGlltEupp.lhcp.hpcps.lpDAsllsuuQthEHYEIAuYGoLhshAcpLGh........s.-ssplLppsLpEEpssDctLsplA.p.....shssttus	...................................p-hahchLpDsauhEKQhpphLtphA...........pths.....N....sc....L.p....tt....hcpHLpET+sQIppl-pll-pp.s.lphp......shK..suMpulhtpupp...lh.t...s..pcp..V+suh...uu.thE+aEIA.s......YsoLhshAcplG.........s.cuhtlLcphLpEEKthsphLpphh.......psspphh.......................................................	0	95	191	252
+5803	PF05975	EcsB		Bacterial ABC transporter protein EcsB	Moxon SJ	anon	Pfam-B_4764 (release 9.0)	Family	This family consists of several bacterial ABC transporter proteins which are homologous to the EcsB protein of Bacillus subtilis. EcsB is thought to encode a hydrophobic protein with six membrane-spanning helices in a pattern found in other hydrophobic components of ABC transporters [1].	25.90	25.90	26.10	30.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.26	0.70	-6.00	52	1578	2009-01-15 18:05:59	2003-05-22 13:16:12	7	2	1026	0	136	965	1	282.60	25	96.02	CHANGED	hppLapcRhpphhpcph+Yl+alhNsHhllhLlh.llGhhuhhYsphLpph..sssh..hh...hllsllhhhllh.hGpltThlccADplFLLshEpc.hpsYlppuhhaShlh.hhh.sllhllhhPlhh..thshshhthlhhhlhhlhhKhh.hhhphphhhhp.............phh.hhhhhhlshhhhhhhh..........hhhhhhhhhlhhhhhhhh.th.ptphhsWcthIphEpc+ttphh+hhshFT-V.plppps+..RRpaL.Dhll...+hlttpp.ppsahaLahRuFlRus-ahulhlRLshluhlhlhh........lsp...alshllshlhlYllshQLhslappactphhhpLYPlsppp+hpuhppllphllhl.sllhslhhhl.thphhhsllhlhssllh	..........ttla.pRhtthhpp..hY.phhhNshhhhhhlh.hhuhhhh.Ysphlpph......s.ph....hh.....h.h.hs.lh.hhhh...ht.ltohhctsDhlFLLshEpp.hp.ahptthhhohhh.hhh.hlh.hhlhhPlhh.....ths.h..hhhhhl.....h.hhhhhhh..hhhph..hh....................................................................................................th...hs.Wphhlt.Epp+h..hhphhshF...T...s...V.t.lp.p.p.st....+RtaL..chll...phhth.....ttha..LahRsalRss-hhslhhRLhhluhlhhhh..........l........hlshhlshlh.YllhhQhhshapt..ht.ht..hh.plaPlstt.t.p.tsh.p.hl.hhh.h.hhl.h...lhhh.hhh..t.hhhhhhhhhh.hh...........................................................	0	25	62	96
+5805	PF05977	MFS_3	DUF894;	Transmembrane secretion effector	Moxon SJ, Eberhardt R	anon	Pfam-B_4880 (release 9.0)	Family	This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin [1], and a protein involved in antibiotic resistance [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	524	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.56	0.70	-6.39	10	4536	2012-10-03 03:33:39	2003-05-22 13:26:29	8	16	2237	0	1344	14705	3116	396.30	20	94.58	CHANGED	sSuaAPLRpssFRslWlAolluNlGshhQsVAuuWLMTolSsSPlMVALVQAAuTLPlFLLulsAGAlADsaDRR+lMlsuQslhAsuSshLslLutlGhloPWhLLuhTFLhGsGuALssPAWQAoVs-lVsRcDVPAAVuLNSlGaNlsRSlGPAlGGlllAuaGsAssFAlsslSYhslIsslhpWKhcsssssLPpEsltsAl+AGLRaothSssl+sVLsRuslFGLuASAlhALLPLVARDpLuGsAhsYGlLLGuhGsGAlsGAlhss+LRcRlsu-pLlthAsluhAhssLsLALosshWlsslsLhluGAuWlsALoslssuVQhusPcWVhGRsLSlYhslhhGGhAAGSalWGsVAEshulssALlsuAsuLLluuhluhhhtLPptcs.DhsPtsc..aspPhVAhsLcPRsGPlllpIEYpIsc-ctssFLcsMtEhR+lRpRsGAcsWsLtRDLpsPppWlEpFhssoWh-aLRppcRlTpADttVpp+lpAhHsGspPPplp+hl...cRPs	...........................................................................................................h.................s....a.t.h....h...h...h...u..p...h...l.o......h....u..........h........h.......h.......t...l........A....h.....s....h........h.......l........h........p.......h.......o........t.......o.......s.......h..h.....l................u....l.....l..s...h.....h...p....h....l.........P...h.....h.....l....h.......u.....h.......h.....u.......G.s.....l.......A.....D............R....a.s.....+..+....+....l........h.....l.....h...s.....p.......h....h....t..s.....l.......s....s....h....h......L.......s........l.......h........s.................h.......h.......s.....h.......h....s.......l..........h.......h.......l....h....h....h....s....h....l....h....G....h....h...s....u....h....t......s....P...u....h...p....u...h....l...P...p..l...V..s....c......c......p..............L...s......p....A....s....u...l......s...............s...h......s...........h...............p.............h....u.........p...l.....l...G..........P....s.......l..u.........G.......l..........l...........l..............u.............h.................h..............G............s.........s.............h..................s..........a...............h..........l.......s.........u........h............s........a......h....h.......s......h.....h......s.........l..........h.....................t...........l...........t............h...............t..............h.............................................t........s..............h..............s..............p..........p................p................h.......h............t........s..................l...........h.............t.......G.............h......c.............a.....l.....h......p.....p..............h.....l........h........h......h..........h........l.....h.......s.....h....l....h.....s........h.........h..........s.......s.....s......h.....h......s........l.......h............P....h...........h...u......p.........p......h.......h........t..............h.........u........s....t..........t..............h..........G.......h........l........h...u....s....h.....u....l.....G..u..l..l..G...u...l.....h...h....s......t......h........t........p.....p.......h...t...........t.......t......h.......h........h.......h.........u.........s........h.........s.......h.......u.........l........s.....h.......h....h.........h..............u.....................l............s.................s..........s.............h..............h.........l...........s.........h...........h.......s.......l........h.....l....h..........G.......h.......s...h......h.......h......s....h......s....s.........h........p.............s.......h.....l.............Q....t.....t.....s...P..s....p......h......h....G....R......l.......u......l....h...t....h....h....h..h.....u.......u.......s........l....G...s....h...h...h....G...h....l....u....p....h....h.......u.....h...h........h....s.....h.....h.....h.....u.....u....h...s...h..l..h...s..s....h..h..h..h...................................................................................................................................................................................................hhthh.....................................................................................................................................................................................................	0	468	932	1185
+5806	PF05978	UNC-93	DUF895; UNC-93_Ce; 	Ion channel regulatory protein UNC-93	Moxon SJ, Pollington J	anon	Pfam-B_4965 (release 9.0)	Family	This family of proteins is a component of a multi-subunit protein complex which is involved in the coordination of muscle contraction. UNC-93 is most likely an ion channel regulatory protein [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.74	0.71	-4.73	11	630	2012-10-03 03:33:39	2003-05-22 13:29:58	11	10	174	0	479	1149	24	133.40	22	29.75	CHANGED	LGhuahhlFoAasopuFItEuVIcSlp-ps.ss.IssaAGYYuhAllYhsFohusLhsPslVshlosKWuhlluuhsashF.hGFLahNpaahYhoSAllGhGuuhlWsGpGsYLoppso+cThE+Noul.WAlhpsSLlhGGlhlhhh.aphpsstuh	.........................................................................................................t.t...G..hhu..hullY..ss.h....s.lus.h.h....s.P....s.l.l....ph.l..G....s.K...h....ol..hl....u....s.h.s....Y..s..h.....a............h.s.....u........h.....a.....s......p.......h............a..............h....h....h....s.u.u.sl.l..G.h...uuu...............h.lW.su....p.u....s...a..........l.......o......p...........h.....s......p..........t...........t.....p..........h........t........p..........................sh.......h.h..............................................tt..................................................................	1	173	248	405
+5807	PF05979	DUF896		Bacterial protein of unknown function (DUF896)	Moxon SJ, Bateman A	anon	Pfam-B_5209 (release 9.0)	Domain	In B. subtilis, one small SOS response operon under the control of LexA, the yneA operon, is comprised of three genes: yneA, yneB, and ynzC [1]. This family consists of several short, hypothetical bacterial proteins of unknown function. These proteins are mainly found in gram-positive firmicutes. Structures show that the N-terminus is composed of two alpha helices forming a helix-loop-helix motif. The structure of ynzC from B. subtilis forms a trimeric complex [2]. Structural modelling suggests this domain may bind nucleic acids [3]. This family is also known as UPF0291.	21.50	21.50	21.50	22.70	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.07	0.72	-4.38	39	1638	2009-01-15 18:05:59	2003-05-22 13:33:07	7	4	1273	5	166	633	4	62.90	48	80.57	CHANGED	cchlcRINELA+KpK.spGLTscEptEQppLRpcYLcsFRsuh+splcslpVlDtp.GpDVTP-KlK	........chlcRINELA+KcK.s.pGLTt-EptEQppLRc-YlcsaRpsh+ppl-slK.l..l..D.c.GpDVTP-Kl+............	1	59	108	136
+5808	PF05980	Toxin_7	toxin_7;	Toxin 7	Moxon SJ	anon	Pfam-B_5254 (release 9.0)	Family	This family consists of several short spider neurotoxin proteins including many from the Funnel-web spider.	27.00	27.00	27.20	29.50	26.80	25.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.16	0.72	-3.91	30	91	2012-10-01 22:06:18	2003-05-22 13:43:09	7	2	7	4	0	96	0	33.90	49	50.57	CHANGED	GCLs+N+aCsshoGP+CCSGLpCKplSIhcohCl	.uCLhhsQaCNALus.+CCssapCKhls.h-uhCl.	0	0	0	0
+5809	PF05981	CreA		CreA protein	Moxon SJ	anon	Pfam-B_5258 (release 9.0)	Family	This family consists of several bacterial CreA proteins, the function of which is unknown.	25.00	25.00	52.10	51.90	23.20	19.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.69	0.71	-4.61	61	1188	2009-01-15 18:05:59	2003-05-22 13:50:15	7	3	1169	0	227	627	37	130.60	57	80.30	CHANGED	lGpVussa.hlGsD..Ill-AhcDPcVpGVTCalSpscsGslcthh..shhEDsS-uSIACRQsG.PIphs.....cp.c....pGEpVFpcppSllFKsL+VsRhaDtcpsoLlYLsYSc+ll-GSsKpSlSsVPlhssps	.................IGsVsTVF+hhGsDc+IVVEAFDDPcVcsVTCYlSRAKTGGIKGsL....GLAEDsSDAuISCpQV...G..P.Ipls.....D+lK.....pGEVVF++RoSL.lF...KoLQVVRhYDsKRNsLsYLuYSDKl......l-......GSPKNulSAVPlhshtt....................	0	42	100	159
+5810	PF05982	DUF897		Domain of unknown function (DUF897) 	Finn RD	anon	Pfam-B_8040 (release 9.0)	Family	Family of bacterial proteins with unknown function	21.40	21.40	23.80	37.70	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.99	0.70	-5.64	7	322	2012-10-02 17:06:44	2003-05-22 13:58:16	7	2	288	0	114	310	521	322.00	38	95.31	CHANGED	PslhFFhhGhlhuhh+S-LtlPtslspsLohhLLhsIGh+GGhtlpp...pslst.hlhshssulhLuhLlshhshhlLp+hsplcphDAhAhAuhYGSlSusTaAsAlohLpc.Ghsa-uahsAhlslMEhPAllsulhl...........................................................slhttp.s....sttshspsp.......t........tpllcEuhhssulslLlGGlhIGlloG.puh.hlp...sFh.slFpGlLslFLL.MGhpAuc+lt-Lpphu.hhllaullsPllhuhlulhlG.......hhs..GhssGshllhAVLuASASYIAuPAshRhulPcANPolYlusSLulTFPhNlhlGIPLa.hthAplhh.t	..........PhlLFFhhGhlusll+S-LclPtslhchLolYLLlAIGh+GGhpLsp...sslss.llh.hlsulhLuhllPlluahlLpthsphspsDuAulAuaYGSlSAsTFs...suluhLp...s....u..lsa-uahsshlAlMEhPAIlluLhL..............................................................hph..t.tp..s............t..t.....................h........................htpll+EshhssullLLlGGllIGhl...s...G.....p...Ghp.lp......sFhsshFpGlLslFLL-MGhsAuc+Lpc.L.p.p.s.G.h.hlsFullhPlltuhlGlhlu......hhh...shusGssllhulLsASASYIAsPAAhRhAlPEAsPolhlsuSLGlTFPaNlhlGIPLY.htl.uph...h...........	0	27	78	100
+5811	PF05983	Med7	MED7; 	MED7 protein	Moxon SJ	anon	Pfam-B_5278 (release 9.0)	Family	This family consists of several eukaryotic proteins which are homologues of the yeast MED7 protein. Activation of gene transcription in metazoans is a multi-step process that is triggered by factors that recognise transcriptional enhancer sites in DNA. These factors work with co-activators such as MED7 to direct transcriptional initiation by the RNA polymerase II apparatus [1].	25.00	25.00	25.10	25.00	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.84	0.71	-4.46	33	334	2009-01-15 18:05:59	2003-05-22 14:01:54	6	7	289	7	234	313	1	170.70	35	71.90	CHANGED	tsouhaP.PPP.ahchasppp............................................-lphhhPPs.....P..ppssYpsFGp.aphc-.............tlPs.L-spGlppLYsps...........................................ts+tpEL+KLs+SLLlsFLE.......................Ll.....slluhsP....pphcp..Klc-lphlhlNhHHLLNc.YRPHQuREoLIhlhcpQlcc++pplcplcptt-clcphlp	................................................................................suh.P.PPs.ah.+.aTscN.........................................................................ph.t.hh..PP............sP...hpssYphFGspapsc-...................hl..s.LEs..p.GlcpLaPtp..................................................................................hD++pEL+KLs+SlLlNFL-.......................Ll.......................slLhpsP.........................pphcc.....Kl-Dlph.LFlNhHHLlNc.aRPHQAREoLhhhhE.Qhcp+pppscchpcph-clpchl.p..........................................	0	79	128	191
+5812	PF05984	Cytomega_UL20A		Cytomegalovirus UL20A protein	Moxon SJ	anon	Pfam-B_5345 (release 9.0)	Family	This family consists of several Cytomegalovirus UL20A proteins. UL20A is thought to be a glycoprotein [1].	25.00	25.00	156.60	156.50	24.20	21.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.32	0.72	-3.81	2	14	2009-01-15 18:05:59	2003-05-22 14:13:27	7	1	6	0	0	20	0	101.60	84	97.33	CHANGED	MuRRlhlLuLLAVoLsVALAAP.QKpKRSVpsEpPusotsGsshT.ptplp.opsGphsDssE-...-YDVLI...-Go...pP..ppssEp.psptKEspp	MARRLWILSLLAVTLTVALAAPSQKSKRSVTVEQPSTST..NuD.NTTPSKNVTLSQGGSTTDGsEDYS.G.-YDVLITDsDGopHQQP.QEKTDEHKpEHTKENEK	0	0	0	0
+5813	PF05985	EutC		Ethanolamine ammonia-lyase light chain (EutC)	Moxon SJ	anon	Pfam-B_5363 (release 9.0)	Family	This family consists of several bacterial ethanolamine ammonia-lyase light chain (EutC) EC:4.3.1.7 sequences. Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia [1].  	23.00	23.00	23.10	29.80	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.61	0.70	-5.29	41	1134	2009-01-15 18:05:59	2003-05-22 14:16:49	6	4	1071	12	212	698	20	234.30	47	80.75	CHANGED	ssssts.sasc.L+phTsARIuLGRuGsu....lsTpplLcFphsHApARDAVasslDh..ttltttlps.........hsh.lplpSpAsDRspYLpRPDLGRcLsscuhtpLpspsstt..............sDlsIVlADGLSutAl..pppuhslLtsLhstLts....shpluPh.llspQuRVAluD-IGEhL........sA+hlllLIGERPG..LoosDSLGhYlTat.P+sG.psDA...........cRNCISNI.+.ssGLs.spAut+lshLlppuhchphSGVsLK	.....................s.hcs-shpcLRp.TsARl.shGRAGsp.....hTpslL+FhADHupA+DuVhptls.........c-hlcs......................shlpV+SpssDKshYLsRPDhGRR.LssEuhcsL+spssts..............sDVplVluDGLSosAI..psNhtplLssLhsuLct......tGlpluss.hhV+huRVtltDpIGElL........GA+lVllLlGERPG..Lusu-SLSsYh......sYs.P...+.....su.psEA............cRsCISNI.H..puGhP.....ssEAAuhlspLh+chLcpKtSGlsL....................	0	58	119	168
+5814	PF05986	ADAM_spacer1		ADAM-TS Spacer 1	Yeats C	anon	Pfam-B_1693 (release 8.0)	Family	This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases [1].	20.80	20.80	20.80	21.00	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.37	0.71	-10.35	0.71	-4.22	23	1464	2009-01-15 18:05:59	2003-05-22 14:39:08	9	158	90	0	835	1201	1	112.10	30	10.54	CHANGED	cslpGsFscpp.t.tGYhcllpIPsGAspIpIpEhphSs.....saLAl+sss..GcahLNGpatlshspp.hphsGoh.hcYsp..sss....t.EpLp..uhGPlpEsLhltlLsp..tspssul+YcahlP	..........................hlpGsaspst.......hG...Y...p.llpIPsGApp.Iplpph.phus...................................saL...A.l....+sps....GcahLNG...s.as...l...s...hs..tp...h......ph.s.G.o........h..hcYpp....sss..............thEplp..uh..G..P..hp-sLhl.......lLht..............t.....p.....sss...lcYpahl...............................	0	119	178	440
+5815	PF05987	DUF898		Bacterial protein of unknown function (DUF898)	Moxon SJ	anon	Pfam-B_5347 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function. Some of the family members are described as putative membrane proteins.	28.00	28.00	28.80	28.00	27.90	27.70	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.10	0.70	-5.55	83	1019	2009-01-15 18:05:59	2003-05-22 14:40:54	8	9	864	0	134	586	125	248.30	35	91.26	CHANGED	.pshphpFsGsu.uEaFtIWlVNhLLollTLGIYosWAKVRp+RYFYuNTplsGpsF-YpusshpllhGhL.lulslllhahlssphs........shhu..............hshhlhhhhhhPall.h...+uhRFphtpTsaRslRFsFpGshtpuhhshlhhslLs.sl....oLGlhh..........................................PhhhtphpcahhspspaGsppFshc...ssstshatshhh......shhlhlhhhhhhshhhh.hhs.hh.ht........................................hshhhhhhhshhlhhhhhhs...ahpsthtNhhhspspl........sthpF..pSslpstphhhlhlsN..........................................................hllhllTLG...................................LhhPastlR.hhR...ahscshsltu.s.slsplhusp.ppp..suAhu-t...huDsh	...........s..pphhFpGsu.tpaFhlhllshLLTIITLGIYssWuhh+hc+ahhtshplssp.htathpshtlhhshl.hhh.......................................................................h.hhh.hhhhh.hhhh....tshpaph..othpsl+h.htsthhthhh.h.hhh.hhhhh.......shhh..hh................................................................shh.......h.......h.hpt..h....G...ht.p.......htht.hhhhhhh.......hhhhh.hhhhhhhhh...........................................................................................................................hhh..hhhhhhhhh.........hh.st..phhhsthth........t.h..ph...tsphp.hthhhhhh.............................................................hh..hohG........................................lhhshh.hh.hhph.hpth.l.....sh.th.......tt.................................................	0	42	86	108
+5816	PF05988	DUF899		Bacterial protein of unknown function (DUF899)	Moxon SJ	anon	Pfam-B_5437 (release 9.0)	Family	This family consists of several uncharacterised bacterial proteins of unknown function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.55	0.70	-4.90	51	520	2012-10-03 14:45:55	2003-05-22 14:44:00	7	1	316	0	226	988	197	222.60	38	92.43	CHANGED	h..sp.slsoRpcWhtARppLLscEK-hTRppDplAspRRtLPh.Vcl-cs....YpF.....-sspGp.soLsDLFs.GRsQLlVYHFMF..uP...............sa.ppuCsuCShluDphsGthsHLpp+DlsLssVSRAPlscltsa+cRMGWp.hPWhSShsuD...FNhDFsVshstt.............................................................p-hPGh.SsFhRcs....GpVaHTYSo...........huRGh-slhusaphLDhTPhGRsEs.................htWhR+HD.......c...Y	......................................................slsspppWhsARctLLscEKt..hTRttDtlAA...pRRtLPh.VcV-.cs....Y.pF..........-uspG.t..soLsDL..Fp..G.RsQ.LlVY+..aMa.....uP..................sh..ctuCsuCShhs.Dph....G.tl.sHLpp+DsohssVSR............A............Plscltsa+pRMGWp..hsWhSot......s.us...FstDass.ht..t..........................................................p-hsGh..os.Fh.R............-s.....sp.VaHT..Y.S.o...........huRGh-tlhssashLDhsPhGRpEs................h.WhphpDt.......................................................	1	55	114	164
+5817	PF05989	Chordopox_A35R		Chordopoxvirus A35R protein	Moxon SJ	anon	Pfam-B_5472 (release 9.0)	Family	This family consists of several Chordopoxvirus sequences homologous to the Vaccinia virus A35R protein. The function of this family is unknown.	18.80	18.80	19.10	19.30	17.70	18.70	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.10	0.71	-4.66	9	54	2009-01-15 18:05:59	2003-05-22 14:47:44	7	1	39	0	0	44	1	157.80	49	96.24	CHANGED	.shhsllTshGVlpIpscph.+sh.sDLGI.sl..l-hlGPYtluolplp.lssshlpppslpcCYlutNGhllpCScpspLshPlpplasuaho+sshllChDc..h.+Lhl-sphQPFYlhoShslhcu..cIlEVYNLYpcGDYphIlNPSssFLphLscpsshCLoDpsGWlIlDu.Ksc	...MDtshlITshGlLpIsD.....Tlh-DLsI.oI..hDhIGPYlIGsIchspIs.lc-IchuDMpcCYFuhpGpllspspsphhphslhpIpsAYho+ssh.l.IsCDh..chhL.lcspaQP...FalhsulslhsA..pIlEsYNLYptGDYphIlNPSsshhhpL..ppshCloDGsGWhIlDs.Ksp.....................................	1	0	0	0
+5818	PF05990	DUF900		Alpha/beta hydrolase of unknown function (DUF900)	Moxon SJ, Bateman A	anon	Pfam-B_5475 (release 9.0)	Family	This family consists of several hypothetical proteins of unknown function mostly found in Rhizobium species. Members of this family have an alpha/beta hydrolase fold.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.76	0.70	-5.04	13	508	2012-10-03 11:45:05	2003-05-22 14:51:33	7	13	338	0	213	832	107	214.60	24	44.33	CHANGED	spsutpshlsscltpsts+clllFVHGaNssF--AlhRhAQIsaDhs.......................hsu..ssllFoWPSpup...lhs.............YsYD+E..SssaSRsALEchL+hLAps........sscclpllAHSMGsaLshEuLRQluhcst..................shss..KlspVlLAAPDlDl.DVFspQhp...........shG+.s........chTlasSp-DRALp.lSphlsGsssRlGshsss.....pptltstGl.....slVDloclcuuDh.lNHspFussPpll....pLlusR	................................................................................ts..........................t.ccl...h..l...FlHGa.N...s....s....a...p.......-.....u........h..h+....h.A...Q.l...s...p...s.......t................................hps.....ssll....Fo..W...P...S.p..u..s.......h..hs.......................................Yh..h..D.+c......us..p..h....o..pss.......L.t....c......hL....p.t.l.....s..ps..........................................s...scclpllAHSMGshlshc...u...Lc..phshpst...................................................................th.t....+lss.l.lLs.u.P..Dl.Dh..-..s..Fp.ppht..................th.s.p.t.........pholasSpcDpALt.hSp..h..l........t....u..s....h.....R..lGt.hss............h.......tl.............hlDh...sph..ts.........t.....h.t..Hs.haht....h............................................................................................................................................	0	53	129	169
+5819	PF05991	NYN_YacP	DUF901;	YacP-like NYN domain	Moxon SJ, Bateman A	anon	Pfam-B_5522 (release 9.0)	Domain	This family consists of bacterial proteins related to YacP. This family is uncharacterised functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind [1].  Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA [1].	24.60	24.60	24.90	25.40	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.22	0.71	-4.50	69	1318	2012-10-03 20:43:45	2003-05-22 14:58:10	6	12	1288	0	277	838	38	157.20	34	60.56	CHANGED	LlVDGYNlIsu.....WscLcclt.cts........L-sARppLl-hLssYpu.aps.hclllVFDAphltG.tpchpph....tslpVlaTc-scTADsaIE+hstpltp.t.....ppVhVsTSDtspQhhlhupGAhRhSuc-hhp-lppsppplp.p........chpp....tpp..ppphhp.......ptlspchhcphcchRc	.........................LlVDGYNhIus......WspLpplt.....cts....................................L-...pARppLlctl......u.s.Ys..u..hpu..hc.......lllVFD.AhhstGh..p...p.p.h.ph.....slcVlF..T..+E..s..E...TADsaIE+hstc.hts.t.............ppltVsTSDhsEQhs.l.a.upG.AhRhSu+ELhpclppscp.plp.p..............phpp....hpp....pp.hht..............h.spc.htphcchh.........................................................................	0	115	208	250
+5820	PF05992	SbmA_BacA		SbmA/BacA-like family	Finn RD	anon	Pfam-B_8139 (release 9.0)	Family	The Rhizobium meliloti bacA gene encodes a function that is essential for  bacterial differentiation into bacteroids within plant cells in the symbiosis between R. meliloti and alfalfa. An Escherichia coli homolog of  BacA, SbmA, is implicated in the uptake of microcins and bleomycin.  This family is likely to be a subfamily of the ABC transporter family.	20.00	20.00	20.40	20.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.07	0.70	-5.23	10	817	2012-10-02 13:23:42	2003-05-22 14:58:56	7	3	763	0	82	1485	1772	298.70	62	77.94	CHANGED	s+cWQhWSlLGTulILFshaFsVQluVtlNsWYGPFYDLIQcALusPsulThs-FYpulhsFhtIAhluVsluVlNsFFVSHYlFRWRTAMN-YYhu+WspL.RHIEGASQRVQEDTMRFuplhEsLGlullculMTLIAFLPlLasLSspVshLPllG-lPauLVhAAllWSLhGTlhLhlVG..IKLPGLEFsNQ+VEAAYRKELVYGEDc.ssRApPtTLcELFssVR+NYFRLYFHYhYFNluRlhYLQsDs.lhshllLsPoIVAGplTLGlMsQIoNsFG+VRGSFQYLlNSWoTIlELhSIYKRLRuFEupIp	...............................................................................................PH+WQ.h.W.S.IL.G.o.u..L..I..I.Fl..T.WF.h..V.p.V.uVAl..NAW...Yu....PF...Y.DLIQ...s...A...L.......o.......o...P.......c....p.......V...o.......l....pp....F......Y..p.....p....l.u.............VFLG.I..All.AV.lI....u.V.L.....N............sF...F............VS.H.YV...FR.W....R.....T......A.....M...........N...........E...........a....Y.........M......u.......p.......W.............p..........p..........L.........R..............H..........I..........E........G.......A.........A...........Q............RVQEDTMRF...A............o............T.......L............E.......s............h............G.....V.....S.......F....I.sAlMTLIAFLPVLlTL..S..s...H..V..s..c...........L...........P...I...l...G....a....I....P..au....LVhA..AIlWSL..h...G.TGL..L.A.V...V.G..IKLP.G.LEF+NQ.R....V.E.....A.AY..R.........K..E.L........V........Y........G.E........D........D........A........s.........R........A.........s.........P.......s.....T........V.R..E.....L.....F...o....u...VR.........+.......N..Y...F...R...L.YF..H.Y.......h.......Y....F.......N....IA.......RILY.......LQ....V..D.N.....l.......FuLalLFPS.IVA...GsITLG.LMoQITNVFGQVRG...uFQYLINSW.....TTl.......VE.....LhSIYKRLRuFE+pL.c..............................................................	1	16	35	59
+5821	PF05993	Reovirus_M2		Reovirus major virion structural protein Mu-1/Mu-1C (M2)	Moxon SJ	anon	Pfam-B_5584 (release 9.0)	Family	This family consists of several Reovirus major virion structural protein Mu-1/Mu-1C (M2) sequences. This family is family is thought to play a role in host cell membrane penetration [1].	25.00	25.00	61.20	54.00	17.70	17.50	hmmbuild  -o /dev/null HMM SEED	674	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-13.03	0.70	-6.71	2	56	2009-01-15 18:05:59	2003-05-22 15:04:45	7	2	25	36	0	67	0	614.20	48	98.52	CHANGED	GNspo.VpThNlTGDGNsFpPou-hoSTAsPulsLpPGhLNPsGh.WhslG..TSVso.suL...........................AlVs.p.t.hshVsEthhtsFoKA.hslph.p.hhpth+shsss.hhSshhThsssYVGsoAtpALsN..pps.VhhsThQsM.lp.oItAth+slthWp.cLcsA.ThLssslshGpsSCshpSllthhcD.LP.DsLhhpYPpEhhsshh+R.sulp....Dsp.sss.scslstVAuuh.AsoupsssL.tpSphhpQAhshhsut-.-lItu.sPlPssVFs.s.tPtsYpsthlK.--ApW...Isch.sosh.hpshs.oGssatlpL..GsTRVlshsthhs.hhsLDluGp.h..-Ts.D.ssphsuFllhQoplPhp.hTsAupIsthTVVshsth.A.s.uhss..QshhshhpLthsaE.Eplsth.P.h..YhLuTFl.sushosoNhopPslhDuLLThoPl.htEsThKGtVVstlVPAplhus.TsEplsuuLsNDAhhhh.s+hsKlAp........A.KhDDsAsss.hS..uV....QhtlSQltps.ss....P..lL.+hApRAhphFlusPShhlp.uhPVLopps.h.ALspGVtTuLRTtSLutGVpsAspKLpuppSlpshpQuFhDpluohaPu.	...........GNAoSlVQshNlpGDGNhFsPSAEToSoAVPSLSLsPGhLNPGGhsWhhIssphssosPuuLRhMTotDlsphu..shsNSoGhlPopuhh.sss.s.c.EsLsVlT-HAIspFsKhpMAhEhsR-aLDtptVsstSsphpsalsYVDCaVGVSARQAhsN.FpppVPVITpoR.s..ahs.ShQshLpsLs.WEhDlRphhTlLPTssshGcloCcM+SVVphlD-QLsDsSLCRhYPcpAAsAlA+RNGGI+...Whssspsps.u.AsNslAASshushAsssPLsEKSstsEpuMcLVsssslDIlsSpsPlsuSVauhsscPpsYNlRTL+l-EAhWLR.h.tosshshphp.hssppuTphHh.L...ptGopVlNL-QhusMhF.lsluGKsYK.cssa...DPss++lsllVhQSKIPFEtWTsASQIsuIs...VutVplaA.t-SShss...ppIIupTSLuYhFERETlsssssElNhYLLsTa..sss.osss.s..P..DsWDulhTloPLouGpVTlKGssV-pVVPuDLlGuYTPEuLsAALPNDAuhlhts+AsKlAc........AIKh-DDussDEsSPhSsPIQG.LAlpQ..L-T..s..t..G.sRhhpP...uhLp+lASRAhphFlGDPpoILpQusPVLpDsslWsuhsQGV+sulRTKSLSAGV+oshsploAspSlQsW+QGFLsKlpshF...............	0	0	0	0
+5822	PF05994	FragX_IP		Cytoplasmic Fragile-X interacting family	Finn RD	anon	Pfam-B_8072 (release 9.0)	Family	CYFIP1/2 (Cytoplasmic fragile X mental retardation interacting protein) like proteins for a  highly conserved protein family [1].  The function of CYFIPs is unclear, but CYFIP interaction with fragile X mental  retardation interacting protein (FMRP) involves the domain of FMRP  which also mediating homo- and heteromerization [1].	20.50	20.50	20.60	21.30	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	820	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.27	0.70	-6.76	9	299	2009-01-15 18:05:59	2003-05-22 15:10:11	6	10	123	1	179	271	13	647.30	51	67.18	CHANGED	scscclhsls.puLplLSphsshVhEh.huaKlhsPss.p...sNctsstt............spcYERAsRYNYoctE+huLlpllAhIKuL...pplhtctEollsptlpcsI.spLQ-FspppLcEsl++ss+....KK-hlpsllpsl+shhsDa.suhc.tpcsthpsc+c........pst.clpl...........L.hlRo.LpSLlssc.thsc+p...hppphcupplpsIctFhpcShaastLLshspsLppssDLSpLWa+EaaL-ls.........................+RlQFPIchShPaILocalLpsp-.PuLh-hlhYPLslYNDuAthALhph+pQaLYDEIcAEsslCh-phsaclu-psFshh+phuushhhDKphhsphpp.th.h....pP..........susRapsLLpQp+lpLLGpsIDlstLluQRlNtthhcpL-tAIsphEupslpulltl-tLl-l.+lTHpLLucah.slssF-shhppAppsso..u.pu+IhlHl.....a.cLshDhlPsYsapuss.R.......h..ttt.tRccss..t.ha.husKslstuasshhpthssFlus.HF+slsRlLshpulsllhpplLc.....hlpsshtsalpshhphhspls+l..PhhshGs.ushshFptplpshlpas-l+.clhpshRplGNslhFsthl-pAL.hpcpstshhpAhshps.hsps...hpcsp-..s.....hppLcphauhLp.hs.l.................s-lhh..phpsshulhc.lLpchcsFl.s.........htss..ssulhsl-oss...pFttlWSslQFlaChPhs.ss-h..........ss.phFG-GlhauusslIsLhsQpc+F-slshChHllplpc....ssscDch.+hlslp+hl-phppaplhssphFtlhsp	......................................................................................................................................................pthh-lsLpGlQLLSpWoutlhEh..hoWKLlHPocch.....pNc.cCPsp................AEEYERATRYNYosEEKhAhlElIAMI....KGL...pslMsRhEolhspAIRpslYutlQDFsQhsLc-PLRpAh+....pKKshl................sll.slRcshsDW.t..u.hc..s....s-ssh+ucK-s..........psshplplsphss..................................................................................tssssQLYMlRThlESLlu-+.sss....K...+...s.............h.+p.pl-..u...hl.tl-pFacpSaaasaLlshS.csLppssDLSQLWaREFaLEhT........................t+RIQFPIEMShPWILTDHILc....op-.................suhhEhVLYsLDLYNDSA.aALstFp+QFLYDElEAE..V...NLCFD...Q..FVaKLu..-pIFsaYK....hAuShLLDK...+h+.s.-sps.uh.h....hP.....................ssRY-.o.LL+QRHVQ..................LLGRSIDLN+LIoQRlssshh+ul-.AIsRFEupDL.o.uIV...EL-hLL-lNRhoH+LLscah.sLDsF-uMhcEANHNVo...............u....PaGRITLHV.....FhELsaDFLPNYCYNuuTpRFV............................+s.hshs....pt.....pR-K...sp..sp......a..laGSK...........LNhAapphhs.YpsFlGsPHhpslsRLLGYpGlAllhcpLL+.h....c.llps...s...l...h...pal...csL.h.psMPK......C+L..Pph-YGSsGlLpaaptpLpslhpYs-lKo.hhpshRElGNsllFshLlEpuL.s.cEssDllpAAP.FpsllPcsh.......hKc...s..p..c.p.sp...........hp+L-spauslp..hss.lp+hus.p.............................................................phthA+-uDLLT+ERLCCGLShFEslLsRl+saLpcs.....................lWp..G.s..P.sN.GVhclD-Cs...EFHRLWSAhQFVYClPss.spEh.........................os.EphFG-GLpWAGC.lIsLLGQQ+RFchhDFsYHlL+Vp+.......................Du+Dc...lc..sl....L...c...+....hs-RlR+aplLNsplhslL...................................................	0	74	97	142
+5823	PF05995	CDO_I		Cysteine dioxygenase type I	Finn RD	anon	Pfam-B_8006 (release 9.0)	Family	Cysteine dioxygenase type I (EC:1.13.11.20) converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate  production.	21.40	21.40	21.90	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.97	0.71	-5.10	8	920	2012-10-10 13:59:34	2003-05-22 15:12:25	7	10	728	11	390	865	131	155.50	22	77.31	CHANGED	Mp.........pssshpssossshlspLtphhpppthsVsphttLhpshpsshs-Wt...hhhhaDtspYTRstl.tGssch-lhLlsWsPGpuoslHDHusStGshplLcGpLpEotashsct...............h....shhspphhhpsGsshhpspttlH+l...........tNsSsscsAVSLHlYhPPhsshsha-pp	......................................................................................................................................................................l...th................ph......h........s.......p.p...Y..tpphl...ps.........s..s.............c..hs.l........h..l..ls..W.sPGps..o..slHD..Hsssash.hs........lLp.G.p..l..p..............E..p.tap.hspp.....................................h......h.s..p.p.h.h...h.t.st..s..s...h.....h........s..t.....ts.l.Hcl.......................tss.s..t..sp...s.ulSlHlY...........................s...........................................................	0	107	212	322
+5824	PF05996	Fe_bilin_red		Ferredoxin-dependent bilin reductase	Moxon SJ	anon	Pfam-B_5667 (release 9.0)	Family	This family consists of several different but closely related proteins which include phycocyanobilin:ferredoxin oxidoreductase EC:1.3.7.5 (PcyA), 15,16-dihydrobiliverdin:ferredoxin oxidoreductase EC:1.3.7.2 (PebA) and phycoerythrobilin:ferredoxin oxidoreductase EC:1.3.7.3 (PebB). Phytobilins are linear tetrapyrrole precursors of the light-harvesting prosthetic groups of the phytochrome photoreceptors of plants and the phycobiliprotein photosynthetic antennae of cyanobacteria, red algae, and cryptomonads. It is known that that phytobilins are synthesised from heme via the intermediary of biliverdin IX alpha (BV), which is reduced subsequently by ferredoxin-dependent bilin reductases with different double-bond specificities [1]. 	25.70	25.70	26.20	26.30	25.30	25.60	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.30	0.70	-4.88	62	239	2009-09-10 22:50:27	2003-05-22 15:14:14	7	4	127	41	111	271	579	213.70	26	84.15	CHANGED	hpplppthpph...slpPh.slssshpthpuphstp....phhIpshhapstthR+l+lptscsGsuLplLssVhaPs.pa.DLPlFGsDl..Vshsst.llA.llDlpPl...ppc.ta.pcahpsLtslh.........ph.shhspspplPt-up.aFSPhhlasR.....ssspp.csthhsthpcYLplahphhppApsh......sss.p..................htclhpuQppYspaptcpDPuRtlLp+hFGppWu-cYlcphLF-	........................................................t...h.t.htth.thtsh..lsttht..hpuphttt....phhlpshsaps.phR.+.h+hthhcsGpshplLpsVhaPps.........pa.D.......LPlFGsDl..lshsst..l.hs..hlDlpPl.......tpptp.h.....ppYhp...tLtsLh..........p..t...h..h.s..pspclst.up.hFS.shslasR..........ssstp.....tppthhsthpcY....Lphahp.hhpp.up..........sstp..................................................................................htphhpuQppYsphptc.pD.s+tlLp+hFGppWu-calpphLFs...............	0	31	72	102
+5825	PF05997	Nop52		Nucleolar protein,Nop52	Finn RD	anon	Pfam-B_8003 (release 9.0)	Family	Nop52 believed to be involved in the generation of 28S rRNA [1].	19.70	19.70	19.90	19.90	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.44	0.70	-4.91	35	436	2009-01-15 18:05:59	2003-05-22 15:24:39	7	5	303	0	284	427	4	187.10	27	44.25	CHANGED	tphths+pLAus-cpsR-+ulc.pLppalsppspp..........sch-hhKlWKGLFYshWhsDKPlhQpcLAsclu.pLlpshpssp..................sthtFhpuFhpoMs+EWssID+aRlDKahhLhR+hlppthphLpcppWct...phlpchhpllhcp...hltsps......hspGlthHlh-lal.....-ELtclhtt........................................lsspslhtllcPFhpl.htpspschLhp.....plpppla..cpl	..........................................t....hhppLAus-phhRppulc.tLppaltsppth..........................st.-hhKlWKGLaYshWh.pD+P..lhQppLupplu.pLlt.sh.stt...................................s.hhFhpsFapohs+EWt.uIDphRlDKahhLlRhhltt............shp..h.lpp............p..................t.Wpt...............phlpthhphh.pt.....hh.sps...................stGlthHhh-lal.....-ELtcsht.t.............................................................................httt...hhlpPahph.htps.sphlhp.phtptlh...h...................................................................................	0	93	146	224
+5827	PF05999	Herpes_U5		Herpesvirus U5-like family	Finn RD	anon	Pfam-B_8027 (release 9.0)	Family	This family of Herpesvirus includes U4, U5 and UL27.	25.00	25.00	37.00	36.00	18.60	17.00	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.62	0.70	-5.89	14	74	2009-01-15 18:05:59	2003-05-22 15:37:14	6	2	28	0	0	71	0	432.70	41	71.31	CHANGED	lcsLpFh--hsthaptlTKhsAlGpYussplhshs.p+sTlutahRhLsEhhstLahphcthh...p.clcsEshtpLtshLsshhspthcssh.spstl..FacscaFtphpssLh.hatlLCuCsEC...R.phFhhatthsht.......++s......stsl+lpshsth..ss.............hcLPhh.HLsttpshsLpsplu+DLGh.Sh..IppslEcp+.LPI.shs.pluhs.pc+slLplhoNIVhhLFllppl+phIhpELshhhchasctltcLphsh........................................Etth..hLssssshpshphhs.......hhc+l...+...hthlpssusp.phhpphp-slchuFpls.atphs.......hhhHhhhltp.....................................ssh-...LstssNLl.aF...tst..p.h.hl.t...slp-s.Ls....s........T+...hhsG...........shshhhpGhpaFt.......................chc.+ththKhhslc+ht.chhh	...................lc-hpalPEhScuuKpIuhAlATGQYsVsoLlsY+.shGTho+YLRpLCshs--LahRL-Gsl....sLhL-sE-+ElItRhLPsslC+tLslcY+sp+sAh.FF+soFhsRsEuAL+clYusFCpCG-.s...R..cthspststsus............................ccus........hS.usssSpascL..Ecs-.LRLppstp.................LGsh+LPAIRHLTAs-ssRVpsuVuRDLGF.uc......WSpoLscca.FLL.PsGh.usus.Pc+GYAhYLASNsVLsLplIRlLRssIR+EasAslRhLoG-Vp+LlRhh.........................................cspu..ALlRpuhuQs.sppR.......tLpRh...+..h.c-lcRhphspssFlcsFCDaL-lspRIPDY+ulS.phpREhLhLHsF+LRR.hhs................................ssosE...ss+spRLlha..l++Gcs.spDtstL.phuosLSDsELS....N........s+...p+As.....s.........lVuhsssulch...........................csHhp+h-RLaVRRhRs+cV.s.................................	0	0	0	0
+5829	PF06001	DUF902		Domain of Unknown Function (DUF902)	Yeats C, Bateman A	anon	Pfam-B_3539 (release 8.0)	Domain	This domain of unknown function is found in several transcriptional co-activators including the CREB-binding protein, which is an acetyltransferase that acetylates histones, giving a specific tag for transcriptional activation. This short domain is found to the C-terminus of bromodomains. The 40 residue domain contains four conserved cysteines suggesting that it may be stabilised by a zinc ion. In CREB this domain is to the N-terminus of another zinc binding PHD domain.	25.00	25.00	28.50	28.50	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.39	0.72	-3.82	8	198	2009-01-15 18:05:59	2003-05-22 15:46:14	8	23	88	31	105	157	1	41.80	80	1.84	CHANGED	PVMpthGYCCG+KhsFsPQsLhCYGKpLCTIsRDpsYasYps	....PVMQSLGYCCG.RKhEFSPQTLCCYGKQLCTIPRDAsYYSYQN......	0	30	41	68
+5830	PF06002	CST-I		Alpha-2,3-sialyltransferase (CST-I)	Moxon SJ	anon	Pfam-B_6887 (release 9.0)	Family	This family consists of several alpha-2,3-sialyltransferase (CST-I) proteins largely found in Campylobacter jejuni.	23.10	23.10	23.10	24.80	22.00	23.00	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.95	0.70	-5.14	7	193	2009-01-15 18:05:59	2003-05-22 15:52:33	7	2	103	15	9	148	3	226.00	41	89.60	CHANGED	.KslIIAGNGPSLKsIDYphLPK-aDVFRCNQFYFED+YaLG+cIKuVFFNPsVFhpQYaThppLlpNsEYpl-pIhCSsh.Nhshl-spp.hc......hptaFsssp.Gap.hlKpLctF.s.alKY+ElY.spRITSGVYMCslAlALGYK-IYLsGIDFYtsstshYsF-spppNlhphhsshpppcsp..hHShphDlpALphLpKhYtlplYuLsPsS.LspahsLus...shs.sFhl.cK.psYhpDILlssp.s..ph.t.h.hK+.+ltpNlh.hL.h+DlLch.p-lK+hhKEK	..................K.lIIAGNGPSlKpIDYSh.LPpDaDVFRCNQFYFED+YaLGKchKtVF..aNs.hh.pQhhThhpLlpNpEYchE...Ihhosh.Nhtphct..c.hhc...........................h.paasssp.uas.hhppLct.F.s.ahpapch..a....sp+hToGlYMhssAlAhGYK-IYLsGID..FY........pphs.ahFcpppppl.p....ht.ppptp..hHoh..p...hDlpAL.hhpcp..YtlplYslsPpS.Lspah.LuP........p.s.tFh...cK...shhp.-hlhss....tph.........tp......p....h...p...h.....................................................................................	0	3	7	9
+5831	PF06003	SMN		Survival motor neuron protein (SMN)	Moxon SJ	anon	Pfam-B_7026 (release 9.0)	Family	This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs [1]. 	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.80	0.70	-5.28	3	460	2012-10-02 16:56:36	2003-05-22 15:59:04	7	15	193	8	279	592	1	149.70	19	54.01	CHANGED	GQSDDSDIWDDTALIKAYDKAVASFKNALKNEDCopPuEs-EpNPGsKRKNNKKNRSRKKCNAAPLKcW+VGDSCNAVWSEDGNlYoATIoSIDtKRGTCVVsYTGYGNcEEQNLADLLsPsoD...s-pt.pEsNlNETEaSTDESDRSS+SHcs+s......pNpspu+sS.WNsRFPPsPPPsPPGF....GRHGEKhc.shPPFLSGWPPPFPsGPPMIPPPPPMSPDusEDDEALGSMLISWYMSGYHTGYYLGLKQGRMEAAluKcuHpK	....................................................................................................................................................................................................................................................t......t..W.p..sG-pC.Ah.a.tpDG..p...h..Y.ApIttl..s...p...tt..ssh...lhatsY.sNt..E.......hts...lh...........tt.............t....t......t........................................................................................................................................................................................................................................................................................................................................................................ptt.....................................................................................................	2	91	127	207
+5832	PF06004	DUF903		Bacterial protein of unknown function (DUF903)	Moxon SJ	anon	Pfam-B_7037 (release 9.0)	Family	This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown.	21.10	21.10	21.60	28.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.13	0.72	-4.44	30	1612	2009-01-15 18:05:59	2003-05-22 16:01:35	7	1	599	28	138	407	4	49.80	54	68.54	CHANGED	shVlsppDGppIlTpsKPchDc-oGhhpYcchs.GcctpIN+DpVpplpEh	..sYVMpTpDGRpIlTDGKPplDsDTGhlSY+Dtp.GNppQINRsDVpphlEh..........	0	10	29	85
+5833	PF06005	DUF904		Protein of unknown function (DUF904)	Moxon SJ	anon	Pfam-B_7038 (release 9.0)	Family	This family consists of several bacterial and archaeal hypothetical proteins of unknown function.	30.00	30.00	30.10	30.00	29.90	29.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.42	0.72	-3.68	35	833	2009-01-15 18:05:59	2003-05-22 16:04:09	7	2	821	4	109	271	20	75.10	62	94.17	CHANGED	MshElL-cLEpKlppAl-TIsLLphEl-ELK-cptt.t.......ptpppL.pENpcL+................pEpssWpcRLcuLLGKlcpl	.....MSLEVFEKLEAKVQQAIDTITLLQMEIEELKEKNssLspEs........QphpcpREpLE+ENppLK................cpQsuWQERLpALLG+MEEV..............	0	15	45	82
+5834	PF06006	DUF905		Bacterial protein of unknown function (DUF905)	Moxon SJ	anon	Pfam-B_7072 (release 9.0)	Family	This family consists of several short hypothetical Enterobacteria proteins of unknown function. Structural analysis of the surface features of the protein YvyC has revealed a single cluster of highly conserved residues on the surface. Additionally, these residues fall into two groups which lie within the two largest of the three cavities identified over the surface. The conclusion from this is that these two cavities with, Leu 58, Glu 75, Ile 82, and Glu 83 and Pro 86, conserved, are likely to be important for the molecular function and reflect the cavities found on the surface of the FlaG proteins in Pfam:PF03646.	22.30	22.30	22.30	22.50	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.46	0.72	-4.60	10	520	2012-10-01 21:18:35	2003-05-22 16:06:47	7	3	290	1	14	219	2	65.50	62	87.11	CHANGED	LhsLP-GPFTRcQApA...VuAsYpNVhIED.DQGsHFRLVVR...ss-GphVWRsWNFEPsAGchLN+YIpopGIh+	...........h.hLP.-GsFoRcQA.A...VsstYRNVFIED.DQGsHFRLVlR....s-GphhWRsWNFEssAGhhhNphlts.GIl+......................	0	2	4	9
+5835	PF06007	PhnJ		Phosphonate metabolism protein PhnJ	Moxon SJ	anon	Pfam-B_7179 (release 9.0)	Family	This family consists of several bacterial phosphonate metabolism (PhnJ) sequences. The exact role that PhnJ plays in phosphonate utilisation is unknown.	25.00	25.00	54.90	54.80	24.20	17.80	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.78	0.70	-5.62	32	691	2009-01-15 18:05:59	2003-05-22 16:13:10	6	3	653	0	123	424	122	272.60	76	95.83	CHANGED	psssYNFAaLDEpoKR.IRRulLKAlAIPGYQVPFuSREMPhshGWGTGGlQlThulIGtsDsLKVIDQGuDDosNAVsIR+FhppTs.GVsTTc+Ts-ATlIQTRHRIPEpPLpcsQILVhQVPhPEPLRhlEPpEscs+pMHA.t-YuhhaVKLYEDIs+aGcIspoacYPVhVNsRYlMcPSPIP+FDsPKhcpssAL.LFGAGREKRIYAVPPYTpVcsLsF-DaPFclppaps.......sCuhCGuocSaLDElhhcDpGs+ha...CSDoDYCpp+htptpt	.........sh.sGYNFAYLDEQTKRMIRRAILKAVAIPGYQVPFGGREMPMPYGWGTGGIQLTASlIGcsDVLKVIDQGADDTTNAVSIRpFFpRVo.GVsTTERTs-ATlIQTRHRIPETPLoEDQIllaQVPIPEPLRFIEPRETETRpMHALEEYGlMpVKLYEDIARFGHIATTYAYPVKVNGRYVMDPSPIPKFDNPKMcMhPALQLFGAGREKRIYAVPPaT+VESLDFDDHPFoVQpWD-.......PCAlCGSscSYLDEV.Vl.....DDsGsRMFV..CSDTDYCcQppptt.pt..............	0	22	65	90
+5836	PF06008	Laminin_I		Laminin Domain I	Yeats C	anon	Pfam-B_1925 (release 8.0)	Family	coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [1].	30.50	30.50	30.70	30.60	30.20	30.40	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.71	0.70	-5.07	9	327	2009-01-15 18:05:59	2003-05-22 16:14:52	9	117	70	0	165	325	1	235.80	22	9.88	CHANGED	p.......lhuls.hTGsh.tsh+l.tphcshpppLpphhtthstpppplpsh-pt.lpsLtp-s-sLtccsspshspupplppsscpThppApsLtttIcpltpslpplhpphtthsp...pt.pssspslppthtpup+hLpplRtR.s.hpp.ppsA-t-hctAptLLsclpphhpp.pt-spuLhpslpcpLscaps+LpDhcphLccAtspsp-ApcLsttsptshp.thpcpppclpcppphhscpLssupshLtpssthLpthspsh	....................................t...p....l.sls..sush....t.hch.hphps....hpp.pLpphhsthp.......tp.plp.h-pp..hpsL..p-hc..pLtp+s........p..ts.ttcupp.h....tpssppshppAppL.p.lpplhpp....lp...t..l.pp.h..thst....tpphss..tplpphhtpspphlp-hRp+...s..httppp.A-tEhptAp....t..LLpplpphhtp.ptc....sp....sl..hps...lpcpLscaps+LpDhpphLpcA..hsps+pAp.....plsttNptphp.thpcphpplpptppphpphLppups.Ltpsp.hhp.hpp..h...............................	0	21	33	81
+5837	PF06009	Laminin_II		Laminin Domain II	Yeats C	anon	Pfam-B_1925 (release 8.0)	Family	It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure [1].	27.90	27.90	27.90	28.20	27.80	27.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.75	0.71	-4.42	8	340	2009-12-23 11:36:11	2003-05-22 16:21:42	7	125	84	1	171	348	0	130.80	28	5.22	CHANGED	uKphAscAscosspVLctlpslspsltphppsluplsssht.hpt.hp..stspsltsAssuV+sLpcpAspLl-+Lcslcphcss.t.....LScNlucIKcLIuQARctAspIKVuspFcscoslcl+s.pcssshsshTsl	........................................................................KthsppAscpstpVhptl..pslp.pslpp.h.....pps...hsphpss..............t...........s.hspsl...s..sA.ss....s..VpsLp...p..phsp.Lhc.KL.csl.......c....php....s............locsIscI+EL.IsQARct.As.p..lpVuhpF.s..Gpsslpl+s..shsshpshTs..............................	0	24	38	93
+5839	PF06011	TRP	DUF907; 	Transient receptor potential (TRP) ion channel	Moxon SJ, Mistry J, Wood V	anon	Pfam-B_5564 (release 9.0)	Family	This family of proteins are transient receptor potential (TRP) ion channels.\	\	They are essential for cellular viability and are involved in cell growth and cell wall synthesis [1].  The genes for these proteins are homologous to polycystic kidney disease related ion channel genes [1].	28.50	28.50	28.60	28.50	28.30	28.40	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.48	0.70	-5.91	75	554	2009-01-15 18:05:59	2003-05-22 16:36:52	7	15	147	0	432	554	9	419.00	23	50.82	CHANGED	ulsassAsluGlullsouhsushut..............................u.......ssAscl......ussshslFtYaQshuhsGMhuVs.hPslhtuaspNFtWShGlIphsFhQphhsha....hpuTGG............ssoshhsshtsh........sh.s........................................................R..............th.h...............................................................t.s...ss..hhhp.......GlpRluhhssIcposhahTu.hhhallhlhhlslhlhhhKhhlclh...................h.+tthh.psschtpa......Rppah...slltG...slhRllh.lhas.lsllshapFspsD..............................................................................................................S..suslllAslhlllhhullsas................................................sh+llhhu+cphphhpss..uhhLYsD.......pslp+aGalYspa+ss.taaahlsslsYhhl+ulhIuhsQs..sGhsQslslhllEhlhllslhhhRPahsKpo.NhhNI.sIsllphlsslhhlhFsshas.stsspulhG.llhhllpAshslhLhlhl...llssllslhp+sP.cs+hps..........................................hpDsR....sSFhppts	.......................................................................................................................h.ltasssslsshullsoshhu.hhu................................................s....sshsph.................usshhs...lhtahQthshhGhhuls.hPshht........sa.spshtW.Sh.G.ll...phs...h...hpph..hs.ha...tsoGG.....................sss..h.h.s..tsh.........................................................p........................................................................................t..............hhh.........Glpphu..hhslptsshh..hTu.hhhah.lhlhhhhhhlhhh+hhl.chh......................................................................................h..+hthh..tpph.ta......Rp.pah...sh.htG...slhRllh..lha..hs..lhshap..h...st...ts......................................................................................................................S........sushllAsl.hl.hh.hhshh.s.ah..............................................................sh.phhhhs+.p.ht..ts.......shhLasD................thlp+aGhlY.spa+ss.taaahlshlhahh.l+uhhluhsQs................sGhs..Qslslh.llEhhhllhl.hhh+Pa...hs...+po.Nhhs.l.hlsslph.lsshhhlhF.ss..h...s..sthsp.....sh.....hG.hlh...hllpu...shslhL..hlhh.........hlpsh.ht..lhpc.ps.chphp....................................t..............................................................................................	0	105	229	366
+5840	PF06012	DUF908		Domain of Unknown Function (DUF908)	Yeats C	anon	Pfam-B_6534 (release 8.0)	Family	\N	25.00	25.00	26.40	30.30	21.60	24.50	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.77	0.70	-5.13	25	318	2009-09-11 20:50:55	2003-05-22 17:01:12	7	40	239	0	225	312	1	287.90	26	8.83	CHANGED	sccLllslLcFophLLEpCsNRslYsSh-.+LssLLsosshcllhusLcllhthupRh..tpt.....st.h..p.hppp.th.hp+lhplAtsastssh..........................................................sstscthuLschh...........tccph.pphsplphpYYhss.......................................................t....+pstttts............................t.ttpsssspsuhphhclsppphpppslp-lhcpthpp..lP............pchpa-hhp+lRhs+uhsssph.....RppllshRlhAIuslshlh...spststs+lhph-s.......hhppLs-Llphs...s.....plspplpshulpuLpulup..++sphss........llssLusslsHGlLhpllRphlspl	......................................................................cpLlhtlLpFotlLlEpsh.sRplYuSh-....+LssLLsosshpllhusLpllhhhupR............p.h.tphhtpphp..hp+.l.pLApsa.............................................................................sspppshuLspts......................tph.tphs.slphpaYsps............................................................................................................................................ptp..ts..spshphhcl.p.ph.h..s.p.s.......tplhpphhp....lP............pppphtlhp+lRlApuhsstpp.....R.phlphRLhAlshLsh.t.....s.pp.hspll.ts.................lh...ppLs-..l.lphs...s...............................ph.hp...l..pshuLpsLsulsp..........cp...s+hss...............llsshus..s..s.HGhL.hllRpslpt........................................................................................................................................	0	71	121	188
+5841	PF06013	WXG100	DUF909; 	Proteins of 100 residues with WXG	Moxon SJ, Studholme DJ	anon	Pfam-B_7198 (release 9.0)	Family	ESAT-6 is a small protein appears to be of fundamental importance in virulence and protective immunity in Mycobacterium tuberculosis. Homologues have been detected in other Gram-positive bacterial species. It may represent a novel secretion system potentially driven by the Pfam:PF01580 domains in the YukA-like proteins [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.81	0.72	-3.98	120	3120	2012-10-01 21:44:22	2003-05-23 10:31:35	7	26	880	30	526	1700	48	84.80	18	66.58	CHANGED	plplsspplppsAsphpptssplpshlp.plpsph.stl.tu..sWp.GsuupuFpsthp.phptsh.pphhptLpplsppLppsuppapps-p	....................hphs.ttlp.st.u.sphps.t.upp.lcsh..hp.plpsph..psl..tu....sWp...Gt.u.sssap.s....t.h....s.p....hppsh.pplh...p.hLpplspplppsusshtpt-t...................	0	169	352	458
+5842	PF06014	DUF910		Bacterial protein of unknown function (DUF910)	Moxon SJ	anon	Pfam-B_7253 (release 9.0)	Family	This family consists of several short bacterial proteins of unknown function.	25.00	25.00	31.00	30.90	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.87	0.72	-4.05	26	915	2009-01-15 18:05:59	2003-05-23 10:36:21	6	1	911	3	89	305	0	61.60	50	83.25	CHANGED	MKTLYDVQQLLKpFGhhVYlGcRhaDIELMtlELccLYcusLlD+..csYhpAcllLp+E+phE	...M+ThYDVQQLLKpFGhllYhGcRlaDIELMplELpcLYcutLlD+..p-YLpAchlL++EHchE......	0	19	44	67
+5843	PF06015	Chordopox_A30L		Chordopoxvirus A30L protein	Moxon SJ	anon	Pfam-B_7254 (release 9.0)	Family	This family consists of several short Chordopoxvirus proteins which are homologous to the A30L protein of Vaccinia virus. The vaccinia virus A30L protein is required for the association of electron-dense, granular, proteinaceous material with the concave surfaces of crescent membranes, an early step in viral morphogenesis. A30L is known to interact with the G7L protein and it has been shown that the stability of each is dependent on its association with the other [1].	25.00	25.00	36.40	36.30	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.49	0.72	-4.37	10	57	2009-09-11 08:38:21	2003-05-23 10:41:39	7	1	46	0	0	32	0	72.70	57	98.13	CHANGED	-EDINEuNF.HLLosLSNssp...DsEFuATLSsl+ElIStINhKlLuINKKSKKNsRss-p...hsaVs+..REssRY	.hEDlNEANFsHLLhNLSNNKD..lDspauuTLSll+ELlStINhKIhsINKKSKKNo..+o.lEp....lpasuu..REhsRh..............	0	0	0	0
+5844	PF06016	Reovirus_L2		Reovirus core-spike protein lambda-2 (L2)	Moxon SJ	anon	Pfam-B_7350 (release 9.0)	Family	This family consists of several Reovirus core-spike protein lambda-2 (L2) sequences. The reovirus L2 genome segment encodes the core spike protein lambda-2, which mediates enzymatic reactions in 5' capping of the viral plus-strand transcripts [1].	18.00	18.00	19.80	19.80	16.30	16.20	hmmbuild  -o /dev/null HMM SEED	1289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.02	0.70	-14.02	0.70	-7.60	4	56	2009-01-15 18:05:59	2003-05-23 11:11:48	6	2	22	3	0	58	0	1162.20	43	99.73	CHANGED	MAsVaGlpLsspLsosTsR+hhp.hpaDpLlosLpsssh.tp.aRuLc.psss.shoslQha.PLNuas.ssthltpshsacsWccaIp-+hpALss.LhRtYPlss.usRhlNPllhsAlsuuFLsspshsthLshLFls...cssIsslhssshohopch.sstcslhTPAGpKYlpLpuYsso.sssPshFuKclssYApsaYasshssp.phhapasuusslL.HFDpPT.G.HhLlPshuss.uhsohllstsshlLlESsL-phphNApAssuosVsRlDQsYHslhusp.sspsoLthRLssLSLLAlpGhQhss.lPspPThusVuuFluRLhu.Gcspphl..Rsc.lhlh.-SPhshsssst..YlphpssphshoIGshshlsDsspPltaLPQYc.ATs.shspupDuhpcssh.PLhspauhhhoGsAhhphhDhstcss.VassspLsphPssYFst-cthpRsLFSphRuhuDRShlKDsAslpahushlsPsssp.lLssuhSMAYlGASusHussDpPlIIcslhuGolPGVPhPpplpQFGYDVspGoIhDlshshPTGTFtFVYSDVDQVpDussDlsAosRtshuhLshshphTssGGshVVKlNFPTpshWpplFpphusphoolaLlKPhlsNslElFLl.FusR...ssuuLpsosulhhFLlshatR.psLscshsplP.hGs...lDDGsoshGlsslcl.sPshSshstshtlsshuhhsuhsssppShhsh.-SpGspssTIhu+RT.hSppRhsRLt.VPhlhssolshQpRhhssss.pLFsspusssTplh.Luhhhshhssussh.sls+hLDLGTGPEsRILSLlPsshsVThsDsRPsAps.usas.shTsalphDYLssuhhsustsDslTsIhSLGAAsAuAuhsLhsulpQLIphlssusspplaLQLNsPLsssuSl..sllEIDppsppYhFsshtRsEPYus.sAL.phlcslhPussloWhThSsohcWhcYslt.uoolo.sDIshAhphS+hsPIh+IDhsphPhch.PsshhVGtpsslplsuhsspsshpsphsuVplhossssNhsuhhuslul.assspscasLshsPspPGIhsh..llshsss.lshGShsIssPssolslsaP..upLDFT.uGsDsclssssaYcLulF..........lhhDGpaphsNP-+.t.hsoAussRVlpalhDluDsalLhYlCDVossslGchIthPLs-l.phsaPsNsslhhShPasuststlp.sGs.hssLss.shVLPsuhtlhshSTultsuhPTahVPsGsYshVhl	...........MAplhGlRLusoLSuPs.cphsppaThc-hhSsLchss...cPW+sL+sptss.slsAVpLhhPLpGhl.sh.hhthshsaspaEpahp.hLpsLt.plLRhYPIusYpschlNshlsNAlVuAFLSN.sahchLshLhls...cs..lpDlhssGhslppah..hctssl.ssAGpKa.lQ.hpsYs.s...ssDPsLFuKpLpsYuhsaYh.shpsh.pahhpH.SsussLlHaD+PoNG.HhLlso.oshs.Assh.lsAhsulLLESCLpQ.thNsps.supPVsR.spshh.h.us.a.ttpsoLpYpLhsLS.hhhNGYQhsc.hPtp.ssthluuhlupLhs.uts.Tsl.Pp.thhplhhDSP.shsGtst.salp+.tht.Ghplusl..hpssspsVtWhPQas.spu.ssD.u.s.lu+hTpLPLRscYushWsGsAL..asshsRppt.Vh..p.hsQhPssYFssD-pauRShFS.hRtltDRSLlKDTAsLhah.p.lsssps+chl.supohsYhGASusHus.sQP.lIcPhhpGplsGV..P.SV+QhGa-VspGsIsDlthPhsoGsa.FVYSDVDQV.sGcsDLshSSphhpS.Ls.hh+hThsGGShVlKhNFPTphVWpaI.ppl.P.hoShhLhKPhVoNNlELahl.Fu.+....puuhpsousVhhFhhsphtRYcsLps..pplPShG....lDDuhoVoslphlsl..suhSshpptttluh.ulhsslGst+hSlt.Y.-SatsplhsIh...oPtStphhsRLtYlPhl.Ppol-VQtRshhsusP.lFs..hsss.sp...LohhYshtloussa.-...schhLDLGTGPEA+.LphlPss.PVThsDhRPhs.PSGCWs.shTsFLphDYLssshlhustuDlVoClLSLGAAsAstshThctuhpQLlp.h.scusspslhlQlNCPhs.sstsl.+thLElspTNppYhF.phGR.EPa.shsuL.cIscshhPshslphhshs.sLpWhchAlhpssoloSssIhlA.hh.+ahPlhhhchcthshph.ssshhVGpsholsl.sapspssapshhssshhhohpsss.suh.stVos..ssspsphsLshs.ussGIho...llts.ss.lSLGShVl-uPDsslo.haP..ApLDholuGTDl-lplssaYclhh.F..........sh.DspapIhp.Dp.......us...sohshNhhhDhuDhahhhhlpDVpspslGhaI.+.L..Lso.shPsstchFLShP.-...hhVp.sGs..s.h.sutshs.PpsW.slssohsh.suhPoahVPPGc.YsLs.........	1	0	0	0
+5845	PF06017	Myosin_TH1	M_tail; Myosin_tail_2; 	Myosin tail	Yeats C	anon	Pfam-B_12631 (release 8.0)	Family	\N	31.10	31.10	31.10	31.10	30.90	31.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.14	0.71	-5.01	27	904	2009-09-13 17:10:37	2003-05-23 11:23:47	8	48	257	0	561	839	2	186.30	23	19.42	CHANGED	h+htAsclhpsKKccptpSl....RtFhGDYluhcp.psphpphhtspt........t........pllFust....VsKhsR....psKsppRtllLTspslYllt............sthphtlK++lslsplpulSlSshpDshhllHh......psptD.llpssaK.........oEhlohLpcphpp.tt..pLplp.husslphph+p........st.pshphthstssss...hhcsspsthhphsss	.......................................+..Asplhts.....+KpphttSl.....R.FhG...DYLshpp.....s.sp...htp..h.htppt.............................................plhFush.......VpKhsR............ptKsppRhllL.......TspslYll.............................sttphpl.Kp.pl.s.lss...........lpulS.l...Ss.hpDshhllHl...................................ppcsDhl..l.ps.s.ht............hEhlohL.hpt.hpp..tt.....plp.lp.hus.phphphpt.............tt.t..hphth.s.ts.....t...............htt.tp.........t.......................................................................	0	191	263	401
+5846	PF06018	CodY		CodY GAF-like domain	Moxon SJ, Bateman A	anon	Pfam-B_7573 (release 9.0)	Domain	This domain is a GAF-like domain found at the N-terminus of several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. Presumably this domain is involved in GTP binding. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2].	29.50	29.50	29.90	29.60	28.60	29.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.92	0.71	-4.99	17	1124	2012-10-02 14:34:25	2003-05-23 11:26:54	9	5	1084	9	136	463	0	176.60	45	67.49	CHANGED	sLLpKTR+lNslLQ+u....sspslsFp-huppLu-VIcsNlallS++G+lLGYuhp...tphps-Rhcp.hhp-+pFP--YspsLhplt-TpuNlslssphosFPhEscp.FtsGlTTIVPIhGuGcRLGTLlLsR.scpFsDDDLlLuEYuuTVVGhEIL+t+s-ElEEEARp+AsVQMAIso	..........................pLLpKTR+lNslLQ+s.........htptlsapcluppLu-llcsNsaIlup+G+lLGYshp....ph.p..s.-Rlcp...hh.p...p...+...p...FP-.-.Yspt.lhplh-TcuNlslc..ss.ho.lF.PsE.s.+-hFs.s.u.l.TTIs.PIhGu.GcRLGTLllhRs..cccFsD-DLlLuEYuuTVVGhplLptpp-E..lEcEsRc+sAVpMAINo......	0	61	93	115
+5847	PF06019	Phage_30_8		Phage GP30.8 protein	Moxon SJ	anon	Pfam-B_7692 (release 9.0)	Family	This family consists of several GP30.8 proteins from the T4-like phages. The function of this family is unknown.	25.00	25.00	36.40	51.50	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.60	0.71	-4.42	2	31	2009-09-11 08:57:46	2003-05-23 11:33:00	6	1	30	0	0	23	0	112.20	68	99.49	CHANGED	MpTINLNATlKs+sasG....hhsEh.WhlhuVpGDll.spTs-G.usDFsapIplcNFFTG.IYcLNoslhGpI.....EppEhG......WY..sARpRAEpLIEKhKthGhlD.t+WphlK	.........MKTINLNAsVKTKCFNG....KYcETMWFLMAVEGDIIEVETTEGMGTDFTFTIQVHNFFTGWIYELNTVIVGKI.....EQNELGE.....WYYVTARQRAERLIEKMKKVGKLDMpHWKVVK..	0	0	0	0
+5848	PF06020	Roughex		Drosophila roughex protein	Moxon SJ	anon	Pfam-B_7712 (release 9.0)	Family	This family consists of several roughex (RUX) proteins specific to Drosophila species. Roughex can influence the intracellular distribution of cyclin A and is therefore defined as a distinct and specialised cell cycle  inhibitor for cyclin A-dependent kinase activity [1]. Rux is though to regulate the metaphase to anaphase transition during development [2].	25.00	25.00	25.10	30.20	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.03	0.70	-5.76	3	54	2009-01-15 18:05:59	2003-05-23 11:40:35	6	2	16	0	8	55	0	283.40	60	98.36	CHANGED	MNAPEEHKcTPLEVIHEFIKGVDDGTIRRDLGEDCILSYYSRNVRGAKAITGFLRTQLTpRYKHEsFEEAAplAKGDELLLQARFGRSFDuERRRIYEEKERsGTTsLHLHAESDDEEVNEEFSTTLITPPRPSSYNLNoLKYVEACGLLNRRDEHlYGGLDLGESCAVHLTLGYRSTaLPGGQVSGFEICLAVYDRGLTSLNRSTLlPPPhuISFuRRANARCNPTTDDEuDoEEDSPPPTuRRGVRRTLFTEENTQEEE..........DuDPDPIPEVE....QEQPAPQQAEETAREAVNIPVDLPTPsETTNsSSYTPRKRhQTTNGNEVPPKRTPGPQRMRF	...................................cTPLEVIHEFIpGVDDGoIRRDLuEDCILSaYSRNVRGAKAlTGFLRsQLThRYKH-sFEEAtplthGDELLLpARFGRSFDhtRRRIYEEKERsu.sT.....LHlH.sE.SDD...Eps...Nc....EFSoo......LITPPRPSSY.N.L..pSLKYVEuCGLLN+.Rs.EH.VYGGLDhG.EoCAVHLTLGYRpT.LPGGpVSGFEICLAVYDRGL.psLpRSTLss.P.huhS...hsRRup...hRCNsTTDDEuDsEED.PPPTuRRsVRRTLFTEENTQcEE..........................D.D.s.Pl.E.p............................QpQP..APQ..Q.s....ppsup...............s....VDlsTP.chTshsShTsRKR.Qt............................................................................	0	1	1	4
+5849	PF06021	Gly_acyl_tr_N	Glycine_acyl_tr;	Aralkyl acyl-CoA:amino acid N-acyltransferase	Moxon SJ	anon	Pfam-B_7828 (release 9.0)	Family	This family consists of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.	25.00	25.00	32.30	25.90	22.50	23.00	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.39	0.71	-4.91	10	198	2009-01-15 18:05:59	2003-05-23 11:49:27	6	4	36	0	101	166	0	181.00	41	67.51	CHANGED	Ml.hLQuuQhLQMLEKSLRKSLPESLKVYGTVFHINcGNPFNLKALVDKWPDFpTVVlRPQEQEMTDDLDHYTNTYplYSKDPcpCQEFLuosEVINWKQHLQIQSSQSuLsEsIpsLAAoKSsKVK+opsILYhssETtK+LsPSLh-sKp.LssssG+P+...ulcQchFKLSoLDVoHAuLVN+aWpFGGNERSpRFIERCIpsFPo	................................Mh.LpssphL.hLcp.LcpplPE..SL.K.VYGsl.hplN+GN..PFph-llVDpWPDFpsVlsRPQ.cp-MsDDhDaYTNsYplaoKD.pphpchLtps-VINWcQthQI.Q..u...Qp.sL..s.-sl.pplA..ss.Kplp..V.chp.pt..hLhhh.phh.p......t..s.s..s.........csp........t.tp..p........t.ppt.h.+.ho.LsloaAsLVNchWphGGNE+ShRaIpchIpsFPo......................................	0	4	8	26
+5850	PF06022	Cir_Bir_Yir		Plasmodium variant antigen protein Cir/Yir/Bir	Moxon SJ	anon	Pfam-B_8754 (release 9.0)	Family	This family consists of several Cir, Yir and Bir proteins from the Plasmodium species P.chabaudi, P.yoelii and P.berghei.	20.40	20.40	20.50	20.50	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.06	0.70	-5.17	119	1443	2012-10-01 19:45:41	2003-05-23 12:01:26	6	3	6	0	1275	1447	0	235.70	29	83.60	CHANGED	M..scp....h..C......ppFptlpphhsDc.Lspssp...YpFpspt..hppYC.ss.s.............Cs..................sD..l-KIsAGsLaLhsp.hats.s.hp..p.s+sphs.lltYIhIWLSYhLsh.csppphs..slp-FYspaIpsssc.Ypp..............pIsss.psYs..sYK-lI-++ptlhs..hshpplSKFY-AFKhLCsMYsph.....st.psssCsphhppAscFVcKYcc.LNp.......sss..scsosYspl...LSoLSsDYsNhKpcCss.....ptph..ssLPshcp.......................................................p.ssSSSSIssKL....lslL.IFs.AIulFLGIu...YK	.....................................C....t.h..l.p.hssp...t.ptp...hph.p.t......hptY.Css..t................pC.p...................ss..hc+l.suuhlaLhpt.hhtp..t...t.............tpt..p..hh.Yhh.lWLu...YhL.s.pp.p..p..t..h.s.....slppFYspaIps...s...p...p...Ypp................lpts......pt...hp......s..ac.-.lI-c+pph.hs..hs..h....p...lScaY-sFK.LCphYsph.....s.t...pss...p.spp......h..p..p...Ap..c.Fs....cc.Ycc.....L.pp.......s......s.....sc....s....s.....sY.ppl...LssLSsDYssh.....Kp.ppss...........h....sslsp..h.pt...............................................................................hspsssh.h..spL....h.lh.Ihs.uhshhlGl.YK.................................................................................................................................................................................................................................................	1	0	903	1275
+5851	PF06023	DUF911		Archaeal protein of unknown function (DUF911)	Moxon SJ	anon	Pfam-B_8782 (release 9.0)	Family	This family consists of several archaeal proteins of unknown function.	20.20	20.20	20.50	20.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.06	0.70	-5.20	8	70	2012-10-11 20:44:44	2003-05-23 12:12:43	7	2	49	0	43	95	1	261.40	34	98.55	CHANGED	Mhhphp.h..+hL.+Rl+th.tscsVsEELRGWpWspPPVpPpsh.ltLolSDls.sYCsTtRDVYL+hVLshRGc.sstlhhGpsIHcsatpulc-l+phhhuucs.s.sh.p.hhtpth....h..phhc....huctlacalsphhpuchscl+...ut.sttsc.Sluhhs..lPhhsEasVDGSsLGLSshlpVDA..hhLs..lVlEhKsGpapcpHcLALAGYALAlESthElPVDaGhLlhl.shNssl.+hpsclhhIu-sLRpEFLEtRDcsh-lltsssDPGluhcCsssCPFhchCp....t	............................................................................................h..+.L.+chh.sh.ttsslsEELRGWsappPPlpPhth.htLulS-lu.tYCsTtRDlYLR.+.Vhthpsc....s.t.shhhGphlHclhtp.shp...php+hl.t.s....h............t..h...............h....h..t....th..............hspph.p.................hsctlhchh..sh..plhuc.hpc.hh.......st....h...........Shs....s......lP..l.h......sEht....VD.Go.LGLS.t..L.ps.......DA.h.h.hs........ll.lEh....K.h..Gp.....h..p...c..h.HcLuLAGYALAlEuthElPlDhGhllYl.sh.s...tsh...chphcshhIussLRpcFl-tRDchh-hltpttD.PG.hs......p...Cs.tsCPFhphCpt...............................................	1	19	29	35
+5852	PF06024	DUF912		Nucleopolyhedrovirus protein of unknown function (DUF912)	Moxon SJ	anon	Pfam-B_8809 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus proteins of unknown function.	26.00	26.00	26.60	26.00	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.59	0.72	-3.96	24	60	2009-01-15 18:05:59	2003-05-23 12:15:59	7	2	52	0	9	56	1	102.10	28	58.08	CHANGED	LDVPY-RLGspp.+V-YIPLKLALsD...............sssssssststss..s..spsshsptsss..........pphshhpllllulluhlslhlLL...YsIYYFVILR-...+pp.......ss....t.pPsal	............................................LDlPY-RLuspp.pV-YIPLKLAlsD...............stsspssspppsss.s..hs.pss.hsstsss..........tspts.hhsllllulluhhslhllL...Ys...IY...YFVILR-+pppts............................	0	8	8	9
+5853	PF06025	DUF913		Domain of Unknown Function (DUF913)	Yeats C, Sammut SJ	anon	Pfam-B_6534 (release 8.0)	Family	Members of this family are found in various ubiquitin protein ligases.	24.70	24.70	26.30	25.10	18.90	23.60	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.09	0.70	-5.71	11	332	2009-01-15 18:05:59	2003-05-23 12:19:24	7	42	240	0	227	319	4	324.60	25	10.30	CHANGED	hSRslchLDshlcuspsAhuhh.osu+GhDslsshIcaEsppshc...........ssptuuuh.spppssshs.......ap...IsYhppphL+hhh+Fls+hhp......uuGhscsLRNLlD..spLlsSL+hlhcpAclFGupVaSsAssllSsFIHNEPTSaullsEAGLocuFL-Als.............................................................ssIhsusEAlosIPsAhuAICLNuSGLcLFpo.p.sAlcsaFcIFpSPpHlKsLpcs.......-hssuLGoshDELlRHpPuLKsslhsulIchlscluhLs+shshspshuu+h.......................................thhssshststthsts.hhp.hsso.sspspsss......................s..thshs-hlhsVuRFLtuhhpNpusCp.FIcpsGlEhlLslhsLssLPhDF	..................................................hshphl-hhht........hshh..s.tpGhshh..hlphElphshp..............................................................p.s..ts..s.p.hp..h..................hp.......h..pptthlKshLph.lp+hhp..................ssshsctlRp....lhD..usL.puL+pIlpN.sc.haGssla.hAsslloshlapEP.o.huslp-sGLs..psh.Lculh...................................................................................................................psl....sop-slsslPsshuAlCLNspGLp.hhp..p..pshc.phh.clhhSspal.s...hppp........................-hssslGsuhDELhRHpPsL+sshhssl.lphlpclsthsps..t..t....h.s.......................................................................................................................................t..................................................................................................................................h...l..hhp.l.s......p...s....t...thp.t.Fl.t.ttGl..llp.hhth.ths........................................................................................	0	72	122	187
+5854	PF06026	Rib_5-P_isom_A		Ribose 5-phosphate isomerase A (phosphoriboisomerase A)	Moxon SJ	anon	Pfam-B_5144 (release 9.0)	Family	This family consists of several ribose 5-phosphate isomerase A or phosphoriboisomerase A (EC:5.3.1.6) from bacteria, eukaryotes and archaea. 	26.00	26.00	26.20	28.80	25.70	25.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.95	0.71	-4.95	58	3557	2012-10-04 00:26:15	2003-05-23 13:17:25	9	10	3267	42	923	2338	895	171.00	42	74.26	CHANGED	lsuVsTSppopthspphGI..sltslsph...splDlslDGADElD.sp.hshIKGGGuALhREKIVAssuccFllllDpoKhVp.pLG..pa..PLPVEVlPhuhphlh+plpp....hGs..ps..plRhs.t......tshlTDNGNaIlDspht...I.pD..PttlpcplpplsGVVEsGLFssh.A-hlllGspcGsp	......................uVsoSptospphcpl.GI.....l.h...s..l.s-V........s.p...lDlhlDGAD....El....s......sp......hphI....KG.....G......G......u..A......LhRE.KIVAssuc+.aI.sIs.DpS.K.h..Vc..hLG...pF.............PLPVEVlPhutstVtRpltc........................hGs..pP...phR.s.t...........................hlTDNGNhIlDlphh.......pI........c...................Phtlpptls.tlsGVV-sGLFssh..A-..h..lllGst-Gs....................................	0	249	520	743
+5855	PF06027	DUF914		Eukaryotic protein of unknown function (DUF914)	Moxon SJ	anon	Pfam-B_7017 (release 9.0)	Family	This family consists of several hypothetical proteins of unknown function. Some of the sequences in this family are annotated as being putative membrane proteins.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.09	0.70	-5.60	5	558	2012-10-02 19:55:49	2003-05-23 13:27:53	7	12	225	0	378	1427	836	252.40	26	71.49	CHANGED	pclpch.hTK+hLIuluLGQlLSLLlTusAhTSuYLAc+.tlNsPshQTFLsYsLLsLVYTshhlaRpGscphh.hIKRKWWKYhLLALlDVEANYLVVKAYQYTolTSlpLLDCWAIPsVllLSWhFLKsRYRlh+IlGVVlCIlGVVhlVsSDVlAGcRu..uGSNPllGDhLVLuGATLYAVSNVsEEalVKsLspsEllGhlGLFGAIISuIQluIFE++-LtuIHWos-huLLalGFALsMFLLYSLhPILIKsoSAThaNLSLLTSDhWSLlIGlFlFHYKVsWLYhLAFsTIhlGLIlYSspppcpsEsscsplpshpccG.ss-sscTsc	.......................................................................................................h............................................................................................................................................................................................................................................................h.....h.h.a....h...h.h....u.h...h.D..l..p.u.N.a..h....h.s..h.Ah..p....Y....T.o.l..s.S.....h.p.LLsshs.Is.....h.s.h.l..l..S.hhhL...t.h...Ra.phhphlG.lhls.l.h.G...lsh.l....s......h..u..D.......h........h......s............s.........p............p.......t..................s.....u...........s............s...............l.....h...GD.....l.l...s...lhu.A.s......l.....Yu...l.ssV..h........c.E....h...h......V........p...p.....h...s...h.....h...c...h....l..u..........h...h.....G...l..F..G...h......l......l....s....u.....h....t...h.......h.......h........h......c.....h......t......t.......h......t..h.............h.....s................t.......h......h................h...h...h..h......s.....a...s..h....s..h....h....h.h...a......h.h..s...h...h........h.....h..h...s.s.u..s.......h..s....l..u..l....L.....o.....s..sh...a....ul.......hht.h.hh...a.t...............h.p.h...h.a....l.u..h....hhh..h...hG....hh..h.......................................h.....................................................................................................................................	1	129	205	295
+5856	PF06028	DUF915		Alpha/beta hydrolase of unknown function (DUF915)	Moxon SJ, Bateman A	anon	Pfam-B_7094 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.57	0.70	-5.29	13	1150	2012-10-03 11:45:05	2003-05-23 13:34:06	6	5	577	4	145	1113	409	233.40	31	85.76	CHANGED	psp.psstpphhPTIaIHG.uGospShstMlsplhscts.sspcsLs..hsVsp-GplphpGplsKcsppPhIclsFccNcs..uohccpupWlcplhscLpppYphpphNhVGHS.GGhuhshYhhcYusccshPplpKhVsIuusFNslps.sts.shh.hhppt.spspTshaptlhpp.ppplssslcVLsluGshpssppoDGhVshsSShoh+alhtpsucsYpcphhsGcpAsHSpLHENspVschltpFLapp	............................................................t......h.pp.hP.T.lalHGau.....uo.t...........pu.ptMlpphp.cps..s......s..........ppllp...........spV..spsGpl.p..h.p..Gp..........l.s..ps.s..ppPll.pl.t..Fcs.N+p...........sshppp........ut........a.....hppslpt.L..p.p............p.....Y.p...h...p..p..hNhV..GHShGsl...sh..s.hYh.............hp..a....s....p.........c......p...s..l....P........plp.KhVsI.....u.....u.sa...Ns...h.....................s..........s.t..........................p...................................................t.t.u....P.....s.....p...h...s......ph...........apph..hth.......c...p.hhs.p.slpVLs..IhG......s..................p..........s..........s....pSD.GtVs.sSutul+Ylltsp.sp.sYpEhph..p...G..p..s..ApHSpLH.-.N.t.pVs.phlhpFLat...................................................................................................................	0	31	73	109
+5857	PF06029	AlkA_N		AlkA N-terminal domain	Yeats C	anon	Pfam-B_13157 (release 8.0)	Domain	\N	26.00	26.00	26.10	26.30	25.50	25.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.48	0.71	-4.03	90	1096	2012-10-02 11:58:57	2003-05-23 13:41:40	6	11	1039	41	244	792	63	115.30	42	29.96	CHANGED	slpL..sYRPPacWsthLsFhutRAlsGlEtl...........................ss..s...........YtRolplss......s.....p......................G.hlplphs.........stp......ptlplpl....sh...sthpsLt.slluRlRRlaDLDADPtsIsstL..pshhsshlstpPGLRlPGuaD	.......h.hpL..sapPPaDWshhLuFLAuRAVsGVEpV...........................s-s.......h.......Y....tRols..lsp...........t........p.................................Gllssps.s....................................t.p...........cs..Lclslss............shhsshs....pslA+.h.pRLFDLcssPptlsusL..........us.Lsss..cPGLRlPGshD.......................	0	58	130	199
+5858	PF06030	DUF916		Bacterial protein of unknown function (DUF916)	Moxon SJ	anon	Pfam-B_7106 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.00	21.00	21.00	21.00	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.63	0.71	-4.32	23	922	2012-10-03 16:25:20	2003-05-23 13:51:56	7	3	256	0	77	620	6	120.50	33	35.26	CHANGED	FuVpsllPcNQssps..oYFDLphcPspppsLplclpN.soccplplclssssAhTNssGhlsYspss.sphD..poLcashschlchscp.....lslsspps+plslslpMPscsacGllhGGlahp-c	........................FsVpshlP.-N.Ql..ccp..poYFDLthpPsp..pQp..lplplpN.poc.cclslpls..lssAs.T.NsNGll-Yspsp..tchD.....poLp......hsls-llph..scp........l.plsscpppslshp.lphPp....c.sF.sGlllGGlhhpp......................	0	27	62	67
+5859	PF06031	SERTA		SERTA motif	Bateman A	anon	Pfam-B_7533 (Release 9.0)	Motif	This family consists of a novel motif designated as SERTA (for SEI-1, RBT1, and TARA), corresponding to the largest conserved region among TRIP-Br proteins [1]. The function of this motif is uncertain, but the CDK4-interacting segment of p34SEI-1 (amino acid residues 44-161) includes most of the SERTA motif [2].	25.00	25.00	30.30	29.20	24.10	23.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.63	0.72	-4.66	15	271	2009-01-15 18:05:59	2003-05-23 13:59:28	8	2	72	0	175	259	0	37.50	46	11.67	CHANGED	lLslSLcKLpphcs.sEssLRRSVLIsNTLRRlQsElc	...lLslSLhKLp.phct...sEPsLpRSVLIsNTLR+IppEh.....	0	23	39	93
+5860	PF06032	DUF917		Protein of unknown function (DUF917)	Moxon SJ	anon	Pfam-B_7195 (release 9.0)	Family	This family consists of hypothetical bacterial and archaeal proteins of unknown function.	26.20	26.20	26.50	29.80	25.60	26.10	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.88	0.70	-5.90	51	579	2009-01-15 18:05:59	2003-05-23 13:59:58	7	16	394	2	281	514	91	333.10	33	69.65	CHANGED	l..otpDl-sluhGuulLGoGGGGsPahGphhstptlpps....tplcllsh.--l....sD-shllssuhhG..uP.s.......lshE+......ls.sGs.EhhpAlctlpc.hhGpc.lsulhshEhGGsNulhshh..sAuthGlPllDuDuMGRAaPphpMsThtlt.Ghss.....sP.hsls-tcG.............sssll.ss........hss..hhsEclsRshss..phGutsshuthPhsuppl+ctu.lhsTlShuhcIG+Alppuctppt..shlpsllchh...sG.......phLF.pGKls-lc...Rc.spsGFshGpsplpGhpt................pspphpl.FQNEhLlAtps.............spslsssPDLIslLDt-supPlsopp...........l+YGh+VtVlulPssshhpotp.Gl-hsG....PpsFG..h.shsatPlp	.............................lstpsl-sluhGuulLGoGGGG..sPahuthhshptl.cps.....tslcl....lss.--l......s--shhhs......suhhG..A..P..s.............VhhE+........hs..pGs..Ehhcshctltc...h.........h...s...........pc.hsuhhshEh............GGsNuhhslh..sAA..ph......G...lP..llDuDsMG.RAaPph......pMsThtlt..Ghss.........sP.hslsDtpG....................shslh....p.s.............hss...ths.EplsRshss........phG..........u.t.shhuhhPhsGppl.........+phu..lhsslohuhclG+sltt.sptppt.....phhpsllchs...sG..............hhLF.pG.K....lh.-Vp........Rc.s......psG.FshGpshlpuhst...............................tspphtl.FpNEpLhAtcs........................spslAhsPDLIshlDhco.....upslsopp.............................l.+YGh+.VtVlulsssshWpotc.GlchsG....PphFG...h..chca.sl................................	0	113	191	243
+5861	PF06033	DUF918		Nucleopolyhedrovirus protein of unknown function (DUF918)	Moxon SJ	anon	Pfam-B_7213 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus proteins with no known function.	25.00	25.00	179.60	179.50	19.30	17.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.68	18	39	2009-01-15 18:05:59	2003-05-23 14:01:47	6	1	36	0	0	38	0	152.40	46	91.30	CHANGED	LEFDslslDLRHVsF..stsuts-.......tEYIlFLNVKRAhYpNFplssDhSLETLAlalYpssphslsG.sphs+sssas-h....lsaNpsD+spSllI-Lss-..ARlVVAKplpssEpYHQRlSGalDFE+R....Hpps....shlc.ssstRstLDREhEIKLhp	LEFDslslDLRHVpF..stsst..ss.......pEYIIFLNVK+AhYpNFplssDhSLEoLAhalYcpsphslsG.sphp+ssshs-h....lsaNcpD+NpSllI-Lsp-..ARllVAKplpssEpYHQRVSGalDFEpRHsps.........hlc.ssppRstlDREhEIKLhp.	0	0	0	0
+5862	PF06034	DUF919		Nucleopolyhedrovirus protein of unknown function (DUF919)	Moxon SJ	anon	Pfam-B_7250 (release 9.0)	Family	This family consists of several short Nucleopolyhedrovirus proteins of unknown function.	21.00	21.00	21.80	21.00	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.95	0.72	-4.35	19	53	2009-01-15 18:05:59	2003-05-23 14:04:59	6	1	52	0	0	48	3	60.20	35	44.30	CHANGED	spspsLppQLscIsptK+plsIc.pHaE+l++lTKsspElpcl-p+lhchR.cFLsaGlppF	......p.pppsLcpQLscIsptK+p.lslp.pHaE+l++ITKsspElppl-p+LhchR.pFLpausppF..............	0	0	0	0
+5863	PF06035	Peptidase_C93	DUF920; BTLCP;	Bacterial transglutaminase-like cysteine proteinase BTLCP	Moxon SJ, Sammut SJ, Eberhardt R	anon	Pfam-B_7277 (release 9.0)	Family	Members of this family are predicted to be bacterial transglutaminase-like cysteine proteinases. They contain a conserved Cys-His-Asp catalytic triad. Their structure is predicted to be similar to that of Salmonella typhimurium N-hydroxyarylamine O-acetyltransferase Swiss:Q00267, in Pfam:PF00797, however they lack the sub-domain which is important for arylamine recognition [1].	20.50	20.50	21.00	21.50	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.25	0.71	-4.84	28	779	2012-10-10 12:56:15	2003-05-23 14:06:43	6	1	470	5	245	627	58	155.80	33	71.69	CHANGED	MssGuhTStPlGHYEFCpcpPsECssss.....tsssslpLTsphWpplhcVNtsVNpsIpPhTDh-laG.hcEhWuYP..sstGDCEDYsLhKR+hLhc.sGhPsusLLlTVVRpssG-GHAVLTVRTD+GDFlLDNLsscVhsWs-TsYpaLKRQSpscsGcWVslpcscss.hVuS	.......................................................................................................s...t.t....h....p...pLtpVNphhNpplp.hs.DhclaG.....pcDYWuhP....h....s.......s....sG....DCEDaslhKhhpLhp.hGlssspLhl..o.h....V+.....s.............p.....s.......p.......u.HhV.Ls..h...t..T..s..p..u..-.......hl.LDNlssplhshs.p...................................tt............................................	0	47	124	172
+5865	PF06037	DUF922		Bacterial protein of unknown function (DUF922)	Moxon SJ	anon	Pfam-B_7397 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.40	20.40	20.40	21.40	20.20	20.30	hmmbuild  --amino -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.14	0.71	-4.91	18	220	2009-09-11 05:34:11	2003-05-23 14:39:37	6	3	125	0	60	151	15	158.70	36	77.91	CHANGED	aYuIsGpTus-L.csLuppGPhht.pupRa.GtTphchshc.hsYtpp.sGtCslssscspLplphpLP+hp..ppsss-lphhW-shhuslc+HEcsHucIA+shs+clEpslhuL..tscssCpplcthlsphssclhpcacppppcFD+lEtsstsphpthlL	................................hYsIsGpTss-L.culuppGPhlt......tp..+h.utTphphshc.hcascp.sssCpVtsspspl+hphoLP+hp..pphuPtlthhW..DshhssI+RHEcsHschA+shsp-lERphhuL...scscCpplRtslsKhhschhpspcpppppFD+VEhsNhsNh.phlL.................................	0	9	28	39
+5867	PF06039	Mqo		Malate:quinone oxidoreductase (Mqo)	Moxon SJ	anon	Pfam-B_7465 (release 9.0)	Family	This family consists of several bacterial Malate:quinone oxidoreductase (Mqo) proteins (EC:1.1.99.16). Mqo takes part in the citric acid cycle. It oxidises L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone. The enzyme is therefore called malate:quinone oxidoreductase, abbreviated to Mqo. Mqo is a peripheral membrane protein and can be released from the membrane by addition of chelators [1].  	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.68	0.70	-6.32	17	1946	2012-10-10 17:06:42	2003-05-23 14:49:47	10	3	1474	0	309	1213	419	469.70	48	94.87	CHANGED	ppspsDVlLIGuGIMSATLGshL+ELcPsWpIplhERL-ssutESSNsWNNAGTGHSALCELNYTsEtsDGoIDIsKAlcINEpFplS+QFWuaLVcpGhlpsPcsFINslPHhSFVhG--NVsaL+KRapALpppsLFcsMcaS-D.-plpcWhPLMM-GRsssp.lAAThhstGTDVNFGtlT+pLhppLppp.shplpas+-VpDl+Rss-GsWpVslpshpsuppp.slpu+FVFIGAGGuALsLLQpSGI.EuKsauGFPVuGpFLtssNP-llcpHpAKVYGKAsVGuPPMSVPHLDTRhl-GK+sLLFGPFAsFSsKFLKpGShhDLhpSl+ssNlhsMLusGhcphsLsKYLlsQlhhSp-cRhssLRcahPpA+s-DWcLhsAGQRVQlIKcstcpG.GhLpFGTElVsucDGolAALLGASPGASTAsslML-lLc+sFs-+hp..pWpsKlK-hlPSYGhcLsscspLhcclpt.oucsLpL	......................................................pppcsDVlLIGuGIMSATLGohL+ELpPpWsIplhERL-ssAt.ESSNsWNNAGTGHuALsELNY...T..s.p.ps.DGo...l.-IpKAlpINEpFplS+QFWuahVcpGhlp.sP.csFIpsl.PHMSFVhG-cNVpFL+pRapALppp.sLFcsMca..o-..Dh..p..pl+cWhP..Lh...M...cG....R....c....s....s....p........l.A.A.T.th.-.tG...TDVNFGtlTRpLhp....p.L.....p.....p.....c......s..sp..lp..h..spEVpslc....+.....p.....s.....-.s.....p......WpVpl..p.s....h......p.s..G....p.t..p...phcu+FVFIGAGGu.AL.LLQKoGIPEuKchuGFP..VuGpFLhsp.N.P-llpp.HpAKVYGKAslGAPPMSVPHLDT.R.h.....l.D.GK+sLLFGPFAs..Fo...sK.....F.....LK...s......G...S...h..h...DL..hp..S..l+...s.....s....N....l.....h.....s.Ml......s......s.G..lc...NhsL....s.KYLlsQl.....h.....h..o.....c......-c.....R...h..psL+caaPp.A+.sED..W.c..Lh..p..A.G.QRVQlIKcst.cp...G....GsLpFGTEVVsupD.G.olAALLGASPGASTA.s.slMLclLc+..s..Fs-chp..pWps+l.KphlPSYG.h.p.Lsp.c.th.hcchhp.TscsLtL...........................................................................................................................................	0	65	172	257
+5868	PF06040	Adeno_E3	Adenovirus_E3; 	Adenovirus E3 protein	Moxon SJ	anon	Pfam-B_7475 (release 9.0)	Family	This family consists of several Adenovirus E3 proteins. The E3 protein does not seem to be essential for virus replication in cultured cells suggesting that the protein may function in virus-host interactions [1]. 	25.00	25.00	29.90	27.40	24.20	20.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.92	0.71	-4.18	4	61	2009-01-15 18:05:59	2003-05-23 14:54:17	6	1	40	0	0	51	0	125.00	48	70.68	CHANGED	IKsEhphoau.....L.LhQPhL.sh.Qhhpt..p+TF.ll.soosSshP......LP.TNp.pophppRapRsLhpoNTTh.+TGGELRG.PTs....sPW.VsGLlsLGlVAGGL.LlLCYLYhPChoYLVVLCCWFKKWG..	...............h.......phs.....LsLapPhl.GTYpC.pGPCpHTFsLVssTssSThs.......PETsp..tph.......l..s.oNTs..+TGGEL+s.P.T-t..hsPaEVVGallLGVVhGGhlhlLs.hYLPCas.lhlhhCWh++hG..........	0	0	0	0
+5869	PF06041	DUF924		Bacterial protein of unknown function (DUF924)	Moxon SJ	anon	Pfam-B_7600 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.80	20.80	20.90	21.10	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.34	0.71	-4.55	154	813	2009-01-15 18:05:59	2003-05-23 15:02:49	6	15	724	2	309	757	800	176.50	40	82.71	CHANGED	lLcFWF.............ptstsp......p.W.FtpssshDppl+pRFts...hhp.tAspGc...Ls.......pWtss.s............pGtLAhlILLDQFsRNlaR...soscAFAs.DshALslAppAlspGhD..p..plss.......pRhFhYhPhhHSE...sls.QcpulpLapph.....ss....................tp..............................slcaApcH+clIcRFGRFPHRNslLGRpSTs-EhtFLpp.sGt	................................................................lLcFWF........................pttt.p.......t...W.F.......s......p.......s.....s......s...hDtpl+p+F..tshhp.tAtpuc.....Lt................................pW..pps..s.............pGtLAhlIlLDQFsRNhaR.......so..sc..AFA..s....DshALslApp.A.l.sp.G..h.D..p....pLsst.....................pRhFhYhP..ahHS...E...shs..Qcpu...lpLappl.......s.s.....................................t.t.......................................s.hcaAhcH+sIIcRFGRaPHRNslLGRtSTsEEhtFLppsG...................................	0	92	175	252
+5870	PF06042	DUF925		Bacterial protein of unknown function (DUF925)	Moxon SJ	anon	Pfam-B_7663 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function. This family was recently identified as belonging to the nucleotidyltransferase superfamily [1].	25.00	25.00	25.60	25.40	23.10	23.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.08	0.71	-4.67	40	786	2012-10-02 22:47:23	2003-05-23 15:05:00	6	3	739	1	139	566	26	158.90	40	86.99	CHANGED	L..ctscp....LsL.P-hhLuAGhlRshVWstLcshss..ssls.....DlDllYFDst...-hohct-tplpppLp.phhP...thsW....-V+NQARMHlhpss........sPYpSopDAlupasEpsTAlGlcls.............tssplclhAPaGL--lashplpPN.st....c.phslappRl.tKpWpppWPpLplht	..............LphhcpLtL.schalAAGhVRNhlWshLpspss.hss.s.....DlDVIaFDs....cho.cpphtlE.p+L.ppphP..................phpW..plKNQuhMHh+ssc........sPYsSopDAhS+aPEpsTAlGlRLs..............................cc.sphELhAPaGL-DlhshpV+Ps.P+....ctchplYppRltpKsWpp+WPpLph..t..................	0	33	66	101
+5871	PF06043	Reo_P9		Reovirus P9-like family	Finn RD	anon	Pfam-B_8265 (release 9.0)	Family	\N	25.00	25.00	219.50	219.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.86	0.70	-5.37	4	51	2009-01-15 18:05:59	2003-05-27 10:08:25	6	1	7	2	0	34	0	262.00	57	99.91	CHANGED	MAD.pRRsFGuYpIpEIThppsQsshNssp....QssSsTpsphusp+hPlLDDGIacLlshLlcGssF-copYsGF-YSHLPsLERsFNTASsYVscpaplhhEphsLctY-hppsISlpuP-FolsLEa.hKscspuppp..EN-...shcslss+lls...........LlslhsR-pE-.hsppl.EGEsAllslhKMalpGFLhaLGcN.ssYD+QLsIEKYRPLLluIlGYEahhuhcs.pKclN+laYpLATFsNYPFslLRapLpSllssPs.IcpcItK-GLFK.IsosshhG.sppoV..hhRGIssSpSFLN.K+YRphRoRhsuNVcplIpsDhSplchss	.......sFGuYpIpElhhppsQsNhNsNo....pNopsTpsphuhp+hPlhsDGlatLhs.LLcGssF-KohYpGaDYSHLPNLEpsFNTASsYVstpYcIshsEhpLcsYshscohSVh.P-FohsLEa.lKscppoDpss..cENE............phKPpT++IVs.............pLlsLhNR-p.E.hsEpl.cGEhAlIslFKLYIpGFLhHLs.N.s..........................................................................................................................................	0	0	0	0
+5872	PF06044	DRP		Dam-replacing family	Finn RD	anon	Pfam-B_8314 (release 9.0)	Family	Dam-replacing protein (DRP) is an restriction endonuclease that is flanked by pseudo-transposable small repeat elements.  The replacement of Dam-methylase by DRP allows phase variation through slippage-like mechanisms in several pathogenic isolates of Neisseria meningitidis [1].	22.70	22.70	23.10	26.80	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.84	0.70	-5.39	6	296	2012-10-11 20:44:44	2003-05-27 10:14:51	7	5	224	2	16	88	13	170.80	60	96.61	CHANGED	MsLaFNppLuKsYKSpSQIlRVLSEsWVt+puYCPNCGsp.lspFsNNpPVADFYCspCpE-YELKSKK...uplushIsDGAYpTMIERIpSDsNPNFFFLTY.sc-acVsNFllIPKHFFTP-hII+RKPLussARRAGWIGCNIsLsplPEuGKIFLVKDpQlh-s-pVhcpapKsLFLRppsh.pSRGWhL-IhpCIDKls.spFoLsplYpFEscL+h+aPpNNaIKDKIRQQLQlLRDKGhIEFlGRG+YRKl	......................................................................MpLaFshpLscp.ppsop+hRlhoEsWl.+puYCPsCGspPhp+F....tNN+PVADhaCspCpEpaELKSKp.......tshu..s..sls..DGAYtTMhcRlpuDsNPNFFF...............................................................psuplhp.p.VhcpappsLFLRppsh..pp+GWhltlhpCID.pl..ppFoLppMYcF.E.scLp..FspNNHIK-KIRQQLQILRDpphIEFhG.RGhY+K..........	0	7	14	15
+5873	PF06045	Rhamnogal_lyase		Rhamnogalacturonate lyase family	Finn RD	anon	Pfam-B_8355 (release 9.0)	Family	Rhamnogalacturonate lyase (EC:4.2.2.-) degrades the rhamnogalacturonan  I (RG-I) backbone of pectin [1].  This family contains mainly members from plants, but also contains the plant pathogen Erwinia chrysanthemi.	19.90	19.90	20.10	20.00	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.30	0.70	-5.04	13	168	2012-10-02 23:57:29	2003-05-27 10:28:12	6	17	36	0	104	163	0	162.80	35	28.74	CHANGED	M...................................................p.p......VllDNGllpVTlSsPsGhlTGl+.YsGl.cNlLch..scppsRG.............YWDlVWs.sGpps.....hh-h..................lcGocFcVIsps-EQlElSFsRTas.S.csssl.....PLNlDKR...aIMh+GsSGhYoYuIhE+lpsWPulslsphRlsFKLspcK.........................................FcYMAluDsRQRhMPhssDRsssRG..psLAYpEAVhLlcPp-spa+...GEV	.........................h.............t.............lhlcNGllplohopPtGhloulp..YsGh...pNllc......spt.....pspG.................YaDhsWp....uttt..........hth..................................................................................................hpssphpll.p....spp.lElSFhp.a..s.p.sp.h..............slsl-h..+........hlhhcusSGhYsYuIh-+.tthP.shsl.sphRlsFKLppcp.........................................FpYMAluDspQR.MP.sp.DR...ps..t.LuY.EAVhLspP.psph+...GpV..............................................	0	12	62	85
+5874	PF06046	Sec6		Exocyst complex component Sec6	Finn RD	anon	Pfam-B_8361 (release 9.0)	Family	Sec6 is a component of the multiprotein exocyst complex.  Sec6 interacts with Sec8, Sec10 and Exo70.These exocyst proteins localise to regions of active exocytosis-at the growing ends of interphase cells and in the medial region of cells undergoing cytokinesis-in an F-actin-dependent and exocytosis- independent manner [1].	30.10	30.10	30.50	30.50	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.79	0.70	-6.43	38	580	2012-10-03 17:31:52	2003-05-27 10:42:54	8	14	271	2	371	521	5	457.30	20	72.59	CHANGED	FpplstlhctFcctlhtlhtshlphscps.sshlVcll+Il-tEEppDpchtthpphtt......................................................tpsRsa+c+hhcslcpulpppap.....pstpthssctth.thL-plt.alhs-LhhVpptlsshaPs.caplhchahp.hYHptlpshLt................pl....sss-hsutcllslLsW.scpYts..hhsphthh..................tsplpPllsssth.ppLhccYhphltpplp-WhsplhcsEpppahp....spsP-.....................ct-G.............hatspsshphaphlppQlplA...usohpscllthslcphsphlpphppshhphlc-chcp..............................................sshh-aLlAhsNsphtst-..........hhsshppcatshls.....p.ht.thsslhsshsclsspshptllchlat.D..Lpshhscla..o....ppWhss.........pshcplssTlp-Yh.sDhpp.lp.sh.hphhhpphhcpllhpYlptlhp.......+phthp.spctpphsc+lppDspthhphFpphh........thhhsphphlphlhthl.....hps.s.l........................hh.hpslhspY.Dhshs......alpulLpsRsDhs+uphppllpphpphhtshp............slhscl	.............................................................................................................tht.h.p.htptl..hh.p.h.hst....tt...thlhphhhllp...E-t..ctth.t.t..............................................................................s+ta+phhhphlp..tshptpht.................t....t.....t..........h..............Lp.ht.hhhp-L.h.stphh....hhP..capl............hphhhp.hYHpthtphlt................pl.......t.t...ht..stphht.........l.ltW..ph..Y.t...hhtp.tht...................................tpltshl....p.......ppL.ppahp..h.tphppa.htphhp.t-hp.t..a.p.....tt.Pp....................................p.pG......................hh..o..h.s.h..l.h.phl....p...pplphu.....................stshptphh..hs.lpth....thlpp..h.ppth..ph........hccphtt................................................................................thhhphhlAhhN.sp.thhp...........................h.ph...ppph...........t.................................th..tth.sshspl....tpp.......shphllp.la..D..lpshh......tcl.h...s.......pcWhss.................pshctlhsT.hpcah.t-hpp..lp....s.h..hph.hhtphtcpllhc.Ylptlhp....................................t+h.hp......tpp.....ppp.hsp+hh...p-hptlhthFpphs.........................p.h.p.hl.t..hhthl..............hps.s.l..........................h.tht..shhp.pa.sDh..p.p......altslL.thR....s.shspp.hptlht..htt................................................................................................................	0	97	158	257
+5875	PF06047	SynMuv_product	DUF926; 	Ras-induced vulval development antagonist	Finn RD	anon	Pfam-B_8083 (release 9.0)	Family	This family is from synthetic multi-vulval genes which encode chromatin-associated proteins involved in transcriptional repression. This protein has a role in antagonising Ras-induced vulval development [1].	25.00	25.00	40.30	40.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.34	0.72	-4.30	10	233	2009-01-15 18:05:59	2003-05-27 12:38:40	6	4	173	0	162	228	3	102.50	61	26.07	CHANGED	ppshsYGuALLPGEGsAMApYlpcGKRIPRRGEIGLTSEpIpsFEclGYVMSGSRH+RMsAVRlRKENQVYSAEEKRALAhhstEERtKREscllupF+ElIc++	......................s..hsYGpALLPGEGuAMApYVpp..G..K..RIPRRGEIGLTS-EIusFEssGYVMSGSRH..RRMp..AVRlRKENQlYSA-EKRALA.FNpEERpKREs+llusF+-hlpc..........................	0	68	90	125
+5876	PF06048	DUF927		Domain of unknown function (DUF927)	Finn RD	anon	Pfam-B_8364 (release 9.0)	Family	Family of bacterial proteins of unknown function. The C-terminal half of this family contains a P-loop motif.	20.60	20.60	20.60	20.70	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.85	0.70	-5.14	39	800	2012-10-05 12:31:09	2003-05-27 14:04:52	6	16	569	0	136	598	113	272.40	28	41.09	CHANGED	FpLs.....psGlhhhthscppps.......hhlsuPltlhAcscDs..p...stsauhllp.aps.DGph.+phshstplLtus.uschhtpLlshGhs.hsspt....hptLspaLpph.....pst.pspssspsGWp....ts.........sFlhscpsh..ussstp.lhh....pstpht..................tthptpGTlcsWpcpluphstGNshLhhul...usAhuusLL...phhs.hpusshHhhGsSSsGKoTshplAuSVaGsPs........thh+SWpuTsNuLEuhAutpsDshLsLDElupscs+-..sssl.lYhluNGpGKtRuspsGss..+sspp	........................................................................................................ptpGhhh.t...tppt.s...............hhlssPltlhsphpD...t.....sss.t.hllp.......sspp..pphs.hst.shl....spcthhpLhph..Gls.lssppt......ppL.spalpt......ssh.hsphsspsGWh.....tu...................................sal.h.s.s.p.l.....hss...s..tp......lhh.......sspsht.......................th.p....spG...Th.csW..pppltp..sp.G...N.h..l.h..hul....ssu.LuusLL......p.hs...hpuh..hhc...h.hGp....SSsGKo.TshplAs.S.VaGsPs..........hhpoWp.uTpNuLEuhAutps.sh.lslDE...l....u....p..s........ss..+p.........sssh.hYsl....ssGpGKtRushsGps..+s.p.t.............................................	1	49	87	118
+5877	PF06049	LSPR		Coagulation Factor V LSPD Repeat	Yeats C	anon	Yeats C	Repeat	These repeats are found in coagulation factor V (five). The name LSPD derives from the conserved residues in the middle of the repeat.They occur in the B domain, which is cleaved prior to activation of the protein. It has been suggested that domain B bring domains A and C together for activation ([1]).	30.00	1.60	33.50	1.60	29.60	1.50	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.07	0.77	-5.52	0.77	-3.41	33	291	2009-09-16 13:35:40	2003-05-27 14:42:21	7	11	8	0	203	308	3	9.00	64	11.44	CHANGED	oLSPDLsQp	.TLSPDLuQT....	0	0	0	0
+5878	PF06050	HGD-D		2-hydroxyglutaryl-CoA dehydratase, D-component 	Finn RD	anon	Pfam-B_8369 (release 9.0)	Family	Degradation of glutamate via the hydroxyglutarate pathway involves the syn-elimination of water from 2-hydroxyglutaryl-CoA. This anaerobic process is catalysed by 2-hydroxyglutaryl-CoA dehydratase, an enzyme with two components (A and D) that reversibly associate during reaction cycles. This component contains one non-reducible [4Fe-4S]2+ cluster and a reduced riboflavin 5'-monophosphate [1].	28.40	28.40	28.60	28.40	28.20	28.30	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.25	0.70	-5.63	163	2269	2009-01-15 18:05:59	2003-05-27 14:48:43	8	13	1163	10	497	1880	94	306.50	21	44.28	CHANGED	hshhsPpElltAu.sh.l...sht..l...........tht.phhh.sstppslssshCshl+s.hu...............................sshh.hschl..l..ssssC-spp+hhp..hhsphts.................hhhhchPpptpp............t......shphatcphc.c..........lhttlcphpupplsp-tl...tpslchhsptcct.hpchhcht...tthPsslss.tphh.hlhptthh.hs.tthhphhptlhschptth.cts.h.........tptthRlhlsG.sPhh.sshph..phlE.psGshllspphsh......sh+hhtshl.ts....................s.luc+hh.p.hss..sh........pp+hctltchhccaps-GllhhshphCcshs..............htthhlcchlcct.slPhlhl-sDh....pssshuplpsRlcAFhE.l	................................................................................................................phhh.pclhhAA.sh.s........sht....L.........................p.h...p.p..ht.pslstshsshl+p.hs..........................................................................................sshh..h.sshh..l..spshss.sph+hhp...hhu.tht.........................................hhhhphs.p.pt....................t...........shthhp..pchp.c........................................lh.plp.hhsp.......l..scpsl.....t.slt..l.hsptpct.lpphhchs...........tt.P.s.lss...tphh.t........hl...hsupat...h..........pphphhhs.pht..tth..ctsph.........hpsh.+h..h.hss.hPhh..s.ph.......phlE...ps....Gh.....shp....sh............hh+.h.h.thh.ts...................................l..hpphh....t.hsh................ctcht.hpphhccap....csl..hthhhpt.sp.sht.....................h.p.h.lcch.lcp...s.lPhh.l-s-.......psss.sGplhs+hpshhp..............................................................................................................................................	0	271	417	461
+5879	PF06051	DUF928		Domain of Unknown Function (DUF928)	Finn RD	anon	Pfam-B_8442 (release 9.0)	Family	Family of uncharacterised bacterial protein.	21.00	21.00	21.10	22.30	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.42	0.71	-4.70	25	177	2009-01-15 18:05:59	2003-05-27 15:01:16	7	5	39	0	58	178	1	184.20	25	72.24	CHANGED	pptGGu...........oRGs......Cs.........tsptsLTALlP...p......ss......hGlTssppPThah....YlPtssssts...pFs....LtD-p.scplYpss..hslss.psGIlulsLP..ssss.sLphGcsY+Whhs..lhC..sspssuss......hVcGhl....pRVphssslppplppss.shcpsslYAcsGlWYDsLssLA.pL+pspPpsstltpcWppLLc..SlsL.pplustPll	..................................t.ptuuuoRss........C.............tsp.s.lssLlP...tsp................................hGhTsstpPThah....YlPtssspph........................pFs........Lh..-pp......p...p..lYpps................hs.l...s...s..p.......s..GIlslsLP......tsss..sL.......cs.s...ppYpWths..lhC....sspsp.s..ss...............hVpGhl....pR..lp.hs......sslpppl.........pp.........ss...s..........hppstlYAp....pGlWaDsLspLu.plppppPps.thtttWppLLp.....ulsL..ptlsp.sh.......................	0	3	38	58
+5880	PF06052	3-HAO		3-hydroxyanthranilic acid dioxygenase	Finn RD	anon	Pfam-B_8515 (release 9.0)	Family	In eukaryotes 3-hydroxyanthranilic acid dioxygenase (EC:1.13.11.6) is part of the kynurenine pathway for the degradation of tryptophan and the biosynthesis of nicotinic acid [1].The prokaryotic homolog is involved in the 2-nitrobenzoate degradation pathway [2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.95	0.71	-4.79	5	387	2012-10-10 13:59:34	2003-05-27 15:14:34	7	5	349	8	226	543	220	145.40	44	74.95	CHANGED	MhslssINlcpWVcEN+GsFpPPVCNKCMH.p-QLKVMaVGGPNpRKDYHIEEGEEaFaQLKGDMVLKVlEcGssR....DllI+pGEhFLLPuRVPHSPQRFANTVGLVVER-RhssEpDGLRaYVusoscsLaEcWFYhpDLGTQLsPlIc-Fa	..................................................slNl.pWl-ENpcLL.pPPVs.Nhpla......p.s...s..ahVMlVGGP..N.tRp.DYH......l.s.p.s................E.a.FYQhcGsMhL+.lh.-..c.....G.....ph..+.....D.l..I+EG-hFLLP.................uplPHSPtR.h.u.sT...lG.LVlERc.R..p.s.p.h.DslcWYC...s..p......C.......s......c............h......laEt.F.h...p..D..lsTplhshhpcF.................................	0	68	127	184
+5881	PF06053	DUF929		Domain of unknown function (DUF929)	Finn RD	anon	Pfam-B_8458 (release 9.0)	Family	Family of proteins from the archaeon Sulfolobus, with undetermined  function.	25.00	25.00	32.80	32.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.87	0.70	-5.29	18	134	2009-01-15 18:05:59	2003-05-27 15:16:42	6	2	92	0	25	86	8	229.60	41	83.04	CHANGED	p+llhlslllllll.lllhlhhsph...............l..t.........spsshs....phhKlSspshussGpstlhaloW.GCPhGAssSWsLYlALp+aGsl..slphphSss........scshsshPGLlFhsa.s.....p..lpFpshY....lYsphlsto.hNGpsl....sphlthG.p.lppp.....lPstlYpllppYpsps..........s.s......Hls.sIlIoGstGoYhhsGs...ls...Pshl......Ssh.......sssYVlpp.Lcsss.......IhsuAshIpphIpc	..........................+lhYlslulLAls.lIIhuslltlppopps.........................................................hps.pstlucAlsSIspssYspVusGo.....plsKl..u.N.p..s....s..pcG..KVclaYVGuEaCPaCAhERhPLssALSRFGsF.SuL+splSSP.......tp+phuNIPTlTFcNY................................cYoSpY........Vsh...-uhEhu.DRpGc.I..................us.....LPpstpslasc..Ysstp...........................uIPFS.hhGshssssP...Sh....Phhh..............pc.....sPptVlcs.LsNPNStpAp.tIluuANLhTApICp.......................................................................................................................................	0	5	10	23
+5882	PF06054	CoiA		Competence protein CoiA-like family	Finn RD	anon	Pfam-B_8535 (release 9.0)	Family	Many of the members of this family are described as transcription factors.  CoiA falls within a competence-specific operon in  Streptococcus.  CoiA is an uncharacterised protein.	20.30	20.30	20.40	20.50	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.47	0.70	-5.57	14	1177	2012-10-11 20:44:44	2003-05-27 15:38:20	6	7	1110	0	142	756	21	285.00	25	86.93	CHANGED	M...L.sAhsppGphlslhpttp.p.......cppaaCPsCtuplhl.....KpGphhhsHFAHcshpsCphhtEsEStpHLtsKthLYpalpp.pc.p.................VplEhYlsElpQhsDlhlNpp...........................................lAlElQCSplshpclpcRTpuYpptGhpVhWllG....pplhhpc............................ploplppphlahsp.shshahach-ht..cph+h+ahhhpcltG...................................................+hahtpcphsht.sphhphhp........................................hsa.pp.h.ph.h.h..pht.hIppplhhtp.h.hp.pc..........chYp................pGpsllphhhtsha......................................htshp.h...p....p...pthhphpp.slchahcsa......................hhhhpcptpt.hpplhsshahhp..h	........................................M...h.hAhstptph.l.h..hp.....t.............cptahCPs....CtppVhL.....+.pG...p....hhsH...FAHc.p.h.p.s.C..p....h..h.........E..s.........ES..cHhtsKthLhp..hhpp..ps.p.........................................Vp...l.Ehh..L.......sc...l.p....Q...hsDl.h.l..sp.p...............................................hAl.El..QC.Ssls.......cplhcRopuYpphGhpVhWl..LG.............pph..hhcp................................................................................plp.h..p.h.thh...hhs....ph..thaha.ph..p....p.hhhha.hh.p......ts............................................................................................................................phah.t.......pth.....tph.plhp....................................................................................p.....h..h...h................h..l.p.p.h.........................hh...................t..h........h.............................................................................................................................................h..........................................................................................................................................................................................................................	0	36	78	111
+5883	PF06055	ExoD		Exopolysaccharide synthesis, ExoD	Finn RD	anon	Pfam-B_8604 (release 9.0)	Family	Among the bacterial genes required for nodule invasion are the exo genes. These genes are involved in the production of an extracellular polysaccharide.  Mutations in the exoD result in altered exopolysaccharide production and defects in nodule invasion [1].	22.10	22.10	22.70	47.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.96	0.71	-5.18	82	395	2009-01-15 18:05:59	2003-05-27 15:49:10	7	1	292	0	170	394	61	182.00	27	87.18	CHANGED	pslsshLcplt....................psppsph..olt-llcshGc+uFusl..lllhuLhhlhPls..lPGhs.olhulhlhlluhQhlhGRcphWLPphltcRplspcplppslpphpshsph.l-+hh+s.RLphlssssh.hplhsuhslhlsshh.hL.h..lPFssslP.uhAlslhululhsRDGllhllGhlhshsshshhshlh	.......................t..hsphLpphh................t...ptpsspl..olt-llstlucRu..FGhl..lllhuLPshlPls...PGho.slhGlslllluhQhhhGpc.psWLPphltc+slpppplpthlpphtshlpp.lE+hh+P.Rlthlssshs.tpl.hGlhlhlhulhlhLP....lP.h.oNhlP.uhulhlhulGllpRDGlhhlhGhlhshhshshhhhh.h...............	0	48	110	136
+5884	PF06056	Terminase_5		Putative ATPase subunit of terminase (gpP-like)	Bateman A	anon	Pfam-B_7152 (release 9.0)	Family	This family of proteins are annotated as ATPase subunits of phage terminase after [1]. Terminases are viral proteins that are involved in packaging viral DNA into the capsid.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.65	0.72	-4.41	16	859	2012-10-04 14:01:12	2003-05-27 16:53:51	7	16	638	0	101	1339	101	56.20	37	11.50	CHANGED	-sRcpAphLYapGapss-IActLshp.stTVauWpcR-pWcshssl.pplptulcsRlsp	..................-sRppAt..hL.Y..a....Q...G....a....ps.s.cIAchLsh...........p..ssTVauWKc.RDp.WcchsP..l..pphp.shtuRhhp...........................	0	19	53	78
+5885	PF06057	VirJ		Bacterial virulence protein (VirJ)	Moxon SJ	anon	Pfam-B_7524 (release 9.0)	Family	This family consists of several bacterial VirJ virulence proteins. VirJ is thought to be involved in the type IV secretion system. It is thought that the substrate proteins localised to the periplasm may associate with the pilus in a manner that is mediated by VirJ, and suggest a two-step process for type IV secretion in Agrobacterium [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.15	0.71	-4.52	12	339	2012-10-03 11:45:05	2003-05-28 10:33:45	6	5	263	0	92	319	18	180.10	39	47.26	CHANGED	pDphAlhhSGDGGWR-lD+clustLQppGlPVVGlDSLRYFWsERoPppsAsDLsRlIchYpc+WpsppVlLlGYSFGADllPtsaNcLPssp+spVp.huLLuLu+psDachplpGWLGhss-Gtt.s.ss-ltplssshl.ClYGp--cD.ssCPsLctpss-sluhsGGHHFDtDYtsLAcpllsuhcsRh	.........................DhlslhhSGDGGW.R.-lDKsluptLpppGlsVVGlD..........S..L..RYF.W......s....c+....oP.....pph....AsDLsclhppYptcWttp...cl...hL...lGYSFGADlhPhsascLsss.psplphlsLLuhu.ppusFplclpGWLGhssct....sssPtlspls.s..s.hlhClYGp-EcD...shCs..s.......pt.p.shchlpLPGGHHFDpc.Y.slAptllpthpt.t................................................................	0	19	38	64
+5886	PF06058	DCP1		Dcp1-like decapping family	Finn RD	anon	Pfam-B_8271 (release 9.0)	Family	An essential step in mRNA turnover is decapping.  In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2 (Pfam:PF05026).  The precise role of these proteins in the decapping reaction have not been established. Evidence suggests that the Dcp1 may enhance the function of Dcp2 [1].	20.60	20.60	23.00	20.90	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.34	0.71	-4.07	9	430	2012-10-04 00:02:25	2003-05-28 11:45:17	8	7	272	7	284	392	3	112.70	32	29.81	CHANGED	hspttppl...sLssLpphDPYIpcIlDhuuaVAlYpFssptscWpKs-lEGThFlYpRuspPhauahIhNRhshcshlEslspshchplpssFLlYR....ssp..pIhulWFYspp-sp+IhpLhppll	..............................................t...tppl...sLssLpRh.DP...h.IppIlph.uupsslYpFs.p......s.s....p.WpK.p-..l.EGoLF.l.....h.....p....R.......s.........s....p........P..........p.......a...shhlhNR...hs...h..........c.Nhscs.l..........sp..s....h.-...hp..lpt..s....a..lla+.........................ssp....pl.hulWFaspp.-pppl.thh...................................................	0	76	137	220
+5887	PF06059	DUF930		Domain of Unknown Function (DUF930)	Finn RD	anon	Pfam-B_8283 (release 9.0)	Family	Family of bacterial proteins with undetermined function.  All bacteria in this family are from the Rhizobiales order. 	25.00	25.00	32.90	45.10	19.90	19.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.23	0.72	-3.77	20	145	2009-01-15 18:05:59	2003-05-28 11:50:12	7	1	106	0	50	101	3	99.30	44	51.86	CHANGED	ltpLssppRlpQlCssEAhcplt+spssapPDplsuashssshhsGsslcAsGAAFRSpspWYclsF+Ccsss-shsVhSFsaplGctIP+ucWschtL..hs	....Lc+L-PssRLEQtCDlEAME+Is+-pstapsD+VlAYuaucPhhptNolcAsGAAFRS+pcWY+LuapCcsDs-phslpSFuYtIGsclPp-pWc++hLh.P..	0	7	23	32
+5888	PF06060	Mesothelin		Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)	Moxon SJ	anon	Pfam-B_8552 (release 9.0)	Family	This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known [1,2].	17.50	17.50	17.60	17.50	17.20	16.80	hmmbuild  -o /dev/null HMM SEED	625	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.30	0.70	-13.09	0.70	-6.47	3	103	2009-01-15 18:05:59	2003-05-28 12:04:28	7	2	42	0	65	83	0	409.20	29	80.15	CHANGED	MALPTARPLLGSCGSPICSRSFLLLLLSLGWlPhLQTQTT+TSQEAALLHAV.sGssDFASLPTGLFLGLsC-EVSGLSME+AKELAMAVRQKNIsLpsHQLRCLARRLP+HLTsEELDALPLDLLLFLNPAMFPGQQACAHFFSLISKANVDVLPRRSLERQRLLsuALKCQGVYGFQVSEADVRALGGLACDLPG+FVA+SSEVLLPWLAuCsGPLDQuQpKAVREVLRSGRsPYGPPSTWSVSTLDALQGLLsVLDESIV+SIPKDVlAEWLQ+ISRDPSRLGSKhTVlHPRFRRDsEQKACPPGKEPpcVDEsLIFYQNWELEACVDGTLLAsQMDLVNEIPFTYEQLSIFKHKLDKTYPQGYPESLIQQLGHFFRYVSPEDIRQWNVTSPDTVKTLLKVSKGQKMs........AQVIALVACYLRGGGQLDEDhVKALssIPLSYLCDFSPQDLHSVPSSVMWLVGPQDLDKCSQRHLGlLYQKACSAFQNVSGLEYFEKI+TFLGGASsEDLRALSQHNVSMDIATFKKLQVDALVGLSVAEVQKLLGPHIsDLKTEEDKSPVRDWLFRQ+QKDLDoLGLGLQGGIPNGYLVLDFNVREAFSSsAsLLGPGFVLsWIPALLsALRLS	.....................................................................................................................................................................................................................h..h...hh..h...................C..hh..h.t.thp.h..t..s....t.t.l..tuhtC......t....h.t....................lsttph.h.........LGsLsC....sh.sst.l......t....us.....lL..tL.tC....ls.sQt.uhp..hl.ttts.hG.Ps.Ws.tslptLt.L..h........ht..........h...h.th.........p.........th........hh......h.h......t......t.............t.................t.....h.........................t........h..............h..p........t.t......tt.............h......s.............s..t..l...pp.p...h..h.h...Ypp......p.hcs........ClssthLtsp.hs.l...th.sh.shpp.plhKt..KLsphY..Pp..G.hPEs.lphls.hhhhh.o..p-ItpWslTS.-TlhuLLt.s....s.......p...............spstsllt+a..lttt.G.p.lstshh....h..h.s.t.hLC.hs.pplpsl...sp.hh.h.st.s..clssCs..pphslLas..KAc.A...F......t.....s.......s..t..s.....t.Ya.hhpsaL................G................G.As...........h.....p-LptLuptNlsM...DhsTFhpLp.p.l...LsltpVptLLG.pl.sLpt.cpps.lptWh.p..pptLst.LGls...........................................................................................	0	4	14	26
+5889	PF06061	Baculo_ME53		Baculoviridae ME53	Finn RD	anon	Pfam-B_8086 (release 9.0)	Family	ME53 is one of the major early-transcribed genes. The ME53 protein is reported to contain a putative zinc finger motif [1].	25.00	25.00	121.70	66.10	23.40	20.20	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.36	0.70	-5.45	21	63	2009-01-15 18:05:59	2003-05-28 12:06:23	6	2	54	0	0	62	0	311.00	28	87.23	CHANGED	+DLRh+FLSpps+plhpull+FAoNYVpGhhpspshh.hsp.t.hphc......hsppopCs.tCtt+F+csschh....Lasllcp.h...s............ssp.s+FchsCpcCtppht.....phssaplYPplsLtslccLsctGFhppYlFPlchchppppcphhhhst....cshacslcpIlpc.KcsNEpIhpIsLp..ThGtllhpEs.psshlc+hps.h.t...ss-ls..hhsssSphhphlpspt.ps..hTYFhEVht+sapph.hs..alsahs+sstth.....CphC+.sKhY..cps....PVLaCS+CGFTsshaFp.....p...hsslhap.csVp..spp...hpsptlhYYDlshat	......................pDLRh+FLSppppplhpuhlcFAssYlpGhhp.pph..hth.t....p.......hhppopCp.pCptpF+pspp.........hLasllcp.h................sspss+F+hsCtcCtpphph........hslhELYPslsLtsVc+LsphGFlp+YlFslshshphpp+phhlhsh....pclapslppIlpp.KpsNEpIppIpLp..ThucllhcEshpshhlcptpp.......ss.lp..hh.tsSphhphlpstp..s..hTYahcVhh+happh.hs...alsaashsspt......CphCp.sKhY..psp.....PVLaCSpCGFTsshaFp.........h.pphtYh.ppVp....hpp.....h+sp..tlhYYDhphh................................	0	0	0	0
+5890	PF06062	UPF0231		Uncharacterised protein family (UPF0231)	Finn RD	anon	Pfam-B_9027 (release 9.0)	Family	Family of uncharacterised Proteobacteria proteins.	25.00	25.00	25.00	25.00	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.54	0.71	-4.23	38	786	2009-01-15 18:05:59	2003-05-28 12:11:05	6	3	779	0	93	332	7	116.70	58	95.91	CHANGED	M-YEFp+s.lsGphhAchSMsHEslGpWhsEElupshpplsplhstIpplcsuptt..-hpLhGpEhoLhlss-ElhVpAN.....sLth-..p-.EhE-shphYDpESh.AhCGLEDFpphLpuWpsFlp	............MDYEFLRD.lTGsV+VRhSMGHEVVGHWFNEEVKcN.LuLLDEVEpAA+slKGSER...sWQpsGHEYTLWhDGEEVMV.RAN........QL-Fu...GD...EM..EE.G.MsYY...DEESL...SLCGlEDFLpVlsAYRsFl....................	0	8	29	63
+5892	PF06064	Gam		Host-nuclease inhibitor protein Gam	Finn RD	anon	Pfam-B_9063 (release 9.0)	Family	The Gam protein inhibits RecBCD nuclease and is found in both bacteria and bacteriophage [1].	25.00	25.00	34.10	34.10	20.20	18.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.33	0.72	-3.89	2	349	2009-01-15 18:05:59	2003-05-28 12:30:04	6	1	243	4	3	150	1	94.40	91	97.43	CHANGED	MNAYhh.DRlEAQsWsRHYQQlAREEKEuELADDhEKGLs.HhhESLChDcL.RHGAsKKuIoRAFDDDVEFQERhuEalRYMsEThu+HQlDI-SE.	.........MNAYYIQDRLEAQSWARHYQQIAREEKEAELADDMEKGLPQHLFESLCIDHLQRHGASKKAITRAFDDDVEFQERMAEHIRYMVETIAHHQVDIDSEV...............	0	0	0	1
+5894	PF06066	SepZ		SepZ	Finn RD	anon	Pfam-B_9064 (release 9.0)	Family	SepZ is a component of the type III secretion system use in bacteria. SepZ is a gene within the enterocyte effacement locus. SepZ mutants exhibit reduced invasion efficiency and lack of tyrosine phosphorylation  of Hp90 [1].	22.70	22.70	22.80	72.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.19	0.72	-4.00	4	76	2009-01-15 18:05:59	2003-05-28 13:21:08	6	1	53	0	1	38	0	96.70	75	99.39	CHANGED	M-AANLSPSGsVLPLAsoINGNssVDEsTGVMpPENGssRslRlhAGlALusoALAAlGsGIAuhCs-suSpp.hLGLGIAuGVLGGlTulGGuLAMKYA	.M-AANLSPSGuVLPLAATINGNsSVDEpTGVMpPENGsSRslRIlAGlALuTTALAALGTGIAhACopsuSop.aLGLGIAoGVLGGVTAlGGGLAMKYA	0	0	0	1
+5895	PF06067	DUF932		Domain of unknown function (DUF932)	Finn RD, Pollington J, Bateman A	anon	Pfam-B_9083 (release 9.0) & Pfam-B_002957 (release 23.0)	Family	Family of prokaryotic proteins with unknown function. Contains a number of highly conserved polar residues that could suggest an enzymatic activity.	20.10	20.10	20.40	20.10	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.48	0.70	-5.06	43	1425	2009-01-15 18:05:59	2003-05-28 13:23:55	6	4	644	0	189	1175	404	205.70	51	80.09	CHANGED	sLushSsRYphlpspplL.....psLpccu.t...shhpotutl+s.GR+has..hhRhtcsspl.......ssthss.llLhsSHDGosuhphhhsshRlVCsNTLshu..usssu..sl+V.H..psssshclt-utpplt.h..pta-phptphcthtphplsps-tpsahpsslshp..................s.tpstpssstshsplhphhcscsp........psohWushNuVsEals+tths.Rss...............cp+tspultGh..sspLpptta	...............................................................HpSRSc.+YsYIPTIslL........csLpcEG.FQ.....PFFACQoRVRD....GRRtaoK.HMLRLR.R.supI.........sGpclPEIILLNSHDGoSSYQMlPGhFRhVCpN...GhVC.....GpshG........ElRVPH..+Gsl..V...t.c..VI.E.G..AYEVl.............u.....lFD+lp-pt-AMp.....slhL..ssst..ppshApAALshR...............................Ys......-c+pPV..Tssp.IL..o.P.RRpEDh.............tpDLWosaQplQENh.lKG.Glo..GRSA.........pG........++h+TRAlpuIDsDl+LN+ALW...............................................................................................................	0	37	102	151
+5896	PF06068	TIP49		TIP49 C-terminus	Moxon SJ	anon	Pfam-B_9170 (release 9.0)	Family	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2]. 	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.24	0.70	-5.75	16	859	2012-10-05 12:31:09	2003-05-28 13:25:51	8	13	383	10	602	1792	868	352.50	52	84.15	CHANGED	RIusHSHI+GLG......LD-sh................................................................pscpsup.........GhVGQhpARcAAGVIlchI+ptKhuGRulLlAGsPGTGKTAlAluIucELG.pcsPFsslsGSElYSsEhpKTEsLhQAFR+uIGlRIKEppEVhEGEVV-lph....-pPhs...spshptsplsLKTschppphcLusclhEsLpKE+VpsGDVIhI-psoGplp+lGRS.stup-aDl..psscaV.hPcGElpK+KElVpsVTLHDlDV.hNuRs...QshlulF....pscpsEIpsclRppINchVscalEpGpAEIVPGVLFIDEVHMLDIECFoaLNRALESshuPIllhATNRGhspIRGT.DhhSPHGIPhDLLDRlLIIsThPYsccEI+pILcIRspEEclpls--Ah-hLscIGpcoSLRYulpLlssApll	.....................................................................................................................RluuHSHI+GLGLc.p.s.h............................................................................................p..sc...s.up.......................Gh.VGQ..pA.RcAu.Gll.l.....c.hI......+p.......tK.......h...A..G.......R...A...l...L...lAGsPG......TGKTAlAhuluQp...LG...scsPFsshsGSEl.aShEhpK....................TE.s.Lh.ps.FR+uI.GlRIKEp.pElh....EGEVsElp..............-p.....shs.........spsh.ppshl..sL.KT..s.chpphhcLssphh-ulpKE+VpsGDVIhI-tsoGtlp+lGR.S...s..h..u..p-..aDh...............tsp.c.aV.hPcG-lpK+KElV.psVTLH-lDV.h.NuRs................Qsh.luhh....pscpsEI.psclRppINp....h..Vscah-pGhAElVPG....VLF.IDEVHMLDIE...CFo..aLNRALES.sh...AP.I.V..Ih.A..oNRGhspI...RG............T.....s............h..pSPHGIPlD.LLDRllI.Ip..T.sYstcElc.pIlp...........IRupp.Eslplsp-.A.lshLs.clGt...coSLRYAlQLlosApl.l.............................................................	0	228	347	506
+5897	PF06069	PerC		PerC transcriptional activator	Finn RD	anon	Pfam-B_9117 (release 9.0)	Family	PerC is a transcriptional activator of EaeA/BfpA expression in enteropathogenic bacteria [1].	22.50	22.50	22.80	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.02	0.72	-3.95	4	532	2009-01-15 18:05:59	2003-05-28 13:31:51	6	3	323	0	17	287	0	72.20	37	68.03	CHANGED	M.l+D+lAcpLEtKGhYRRAA-RWucVMl.lp.oDtcR+hss.+Rs.ClpKup+sPls.s.Nho-l+pAVs+sapcMGlshsscclFRpYpss	...........h.....phApcLEu+GhaRRAAshWhtshtpsc.o-spRp.hhtRRppCLpKuu.......+......shs.......................................s.....................	0	1	1	8
+5898	PF06070	Herpes_UL32		Herpesvirus large structural phosphoprotein UL32	Finn RD	anon	Pfam-B_9125 (release 9.0)	Family	The large phosphorylated protein (UL32-like) of herpes viruses  is the polypeptide most frequently reactive in immuno-blotting analyses with antisera when compared with other viral proteins [1].	25.00	25.00	55.60	55.40	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	839	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.42	0.70	-13.57	0.70	-6.08	9	59	2009-01-15 18:05:59	2003-05-28 14:01:11	6	2	25	0	0	58	0	674.30	31	98.07	CHANGED	Ms.....LsFltLs++sVspLspFLcsL.pcssVDLcpHP+llpcC...stcpLpRcosLaNpLlLWLtYYcpLph+pPDhpsLhc-hchptsslschspthshhp.spuhscLsslspssFts-hpscscll.pshhs...LA+h...tttp.lshG......hsFlNL+sc-spclccNLpssppNMhphpslcls..pptNssLVsslNKLlYLG+lllslppSWpcLpctCLs+Ipphp+pLl+pl+pshuFsusYspNlLc+sV.-GpospslLchLtEDasIacsu...............LEasD................................................................................................................................shpSpp-cc--.sssp..shh.................................................................................s.ptssh.sp-Esssccc.t.tu.tst....sppp..soh..Dlpsuspsst.sss.tsspothh.E...........................Pttustss.s.ph.u.....s.p.Phhuss..ssphsP.p..........s...thshtsshh..........hss.s.hs.s..shstshsshsshchpspsth.sp.p.PsspcsosssophssspR....tsps......p.sspspEshss..pctpsoDspsVhphtph..t..h.......sspssp+ucpphhht.phssstssss......spspPshs.h..sssssshsphhp.s.....h.ss..ph+shtsh.spshss.sosl+P.shssts...sssptlssspsssssttsthPuutus.........................p..p..............st.thpss.utph.....................hpssshscl.tthsthshtssssus..hp...........s.hopthsuss..........................................stsshsthtsspss--sltsllp+hptctpp........................pc	.........................Mu.LtFltLp+psVstlhpFLppL.ph.slsLptHP+lltcC...ttppLpRcohLaNchhLWLtYaccLph+pPD...hpslLpchc.ptstlsphs..hshP.hs..thcuhsclslh-cs...atsDhh.cs-l.l.+ul.s...LA+h...ph.p.hspuh.....huFlpL+sp-Vpclt-NlcsstpNhhhhcslclp.shp.ssshV.shN+LlYhG+LhhslppSWppLpchCLsRIpphp+hLltth+.p..uFspsYspNlLc+sV.sGsoA.sLLchL.EDFtlahsu..................LcasD.t.......................................................................................................................hhhpSt.-scs.Dss-..............................................................................................ttssh..t-..Esssptt..........................D.tss.tph...........................................P.hu.tssss..t.ssh.s.sstppshssst..shphpP..................h..ssh...........hss.t.................phphsspsps.sp.p.Psp.pssss.ou.psstt.....shu....tsctsspcpEt......c.s.puoDstpVhphtc..............ssphspp....up.phhhthphsp..Ttss......sppcP.ht.hh.ss.ssshsphhtss..............php.tp.h.sss.ssssohl...shssth...sp.p.l.ssttsps.t.st.Pputsp.........................p..p.s.....p.......ss..hhsp.usph..........................hpsh..shpth...psstts...............s.hotthtut.............................................................................t.............................................................................................................	0	0	0	0
+5899	PF06071	YchF-GTPase_C	DUF933; 	Protein of unknown function (DUF933)	Moxon SJ, Studholme DJ	anon	Pfam-B_10000 (release 9.0)	Domain	This domain is found at the C terminus of the YchF GTP-binding protein (Swiss:O13998) and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies. 	20.10	20.10	20.70	20.50	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.65	0.72	-4.19	44	5012	2012-10-03 10:59:06	2003-05-28 14:04:36	8	16	4777	7	1296	3379	2253	82.60	63	22.65	CHANGED	LtTaFTsGscEVRAWTI+pGspAPpAAGlIHoDFE+GFI+AElluY-Dhlph.s...oEstuKEsGKhRhEGK-YlVpDGDllpF+FN	..........LtTYFTAGsc.EVRAWTI+pGspAPQAA.GlIHTDFE.+GFIRAEslu.Y........-Dhlp.h....s......uEpu..............A..KEAGKhRhEGK-YlVpDGDlh.pFRFN..................	0	463	849	1106
+5900	PF06072	Herpes_US9		Alphaherpesvirus tegument protein US9	Moxon SJ	anon	Pfam-B_7164 (release 9.0)	Family	This family consists of several US9 and related proteins from the Alphaherpesviruses. The function of the US9 protein is unknown although in Bovine herpesvirus 5 Us9 is essential for the anterograde spread of the virus from the olfactory mucosa to the bulb [1].	22.40	22.40	22.40	44.00	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.01	0.72	-4.14	10	46	2009-01-15 18:05:59	2003-05-28 14:28:17	6	1	28	0	0	46	0	57.90	49	47.07	CHANGED	CYYSESDNETAs-FL+RlG++Q.spR+..RRRpChlsluhlhsslllCslSuhLGulluhhl	CYYSESDsETAs-FLhRhGRpQ.shR+..RRRRshhsluhlhsslllsslSuhlGulluhhh..	0	0	0	0
+5901	PF06073	DUF934		Bacterial protein of unknown function (DUF934)	Moxon SJ	anon	Pfam-B_8947 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function. One of the members of this family Swiss:Q8YEW3 is thought to be an oxidoreductase.	25.00	25.00	25.20	25.10	23.70	23.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.45	0.72	-4.36	75	595	2009-01-15 18:05:59	2003-05-28 15:08:50	7	3	527	0	191	481	128	109.70	38	66.70	CHANGED	GVhlss---sc.pL....ts..pLspl..sllAlsFPsFsDGRuaSpApLLRcRhGapGELRAlGDVLhDQlhaMpRsGFDuFslcs....stshpsAhc.shscFosh....YQsuss.....pstsha..pRp	.....................uVhlssc--sp...sL....ts......cLspl..slIulpFPsFsDGRuaShAcLLRpRhGapGE..LRAhGDVLhDQlhahpRsGFDuaslcs....cpshc....c....shc....sh....scassh....YQsust....t..s.............................	0	42	107	148
+5902	PF06074	DUF935		Protein of unknown function (DUF935)	Moxon SJ	anon	Pfam-B_10021 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function as well as the Bacteriophage Mu gp29 protein Swiss:Q9T1W5.	20.30	20.30	22.30	21.70	19.90	20.10	hmmbuild  -o /dev/null HMM SEED	516	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.43	0.70	-5.79	54	588	2009-01-15 18:05:59	2003-05-28 15:19:29	7	5	459	0	91	595	77	428.60	21	92.12	CHANGED	M.sp...........s.ht.....t.ttphpsph..tthshhtt.h...psupGlo.sschssILcsstpGs.lps.t-Lh..h.t+DsHltuplppRKtAl.....hul-Wplpssss.sstcp+hA-hlc-hlpchs...........hccllh-hhDAlhhGaushEl.hW..tpps...shahspslph+s.caFphsppst..........cl+hpsss.......Gp...L.shpalh+pp+ucss..shttGLh+hlhWsahFKphul+.aspFhEhYGhPhtlGKYss.uAspp-+ss....LLcAltslspsAuulIPcsMplEhhcAus....uusssapphlcas-pplSKAlLGQThT..op....sssuspAtuplHs-VRcDlhpuDsc.lspTlsptLltslhtlNh...tsstphPphph.ppEstDhpt.......hu-shppLssh.Ghchst...pahp-chsls.sptspsshshsstss............stth.........................................stttt.t................pstlDshhsph............hsphpts.hcshlpslhshlppusoh--hhppLh.phh.sphsssphtchlucuhhsAclhGphss	..................................................................................................................................................................................................................................................................................................hh....p...hhpt.tts..........plh.....p...DspltuthtpR+tul.....hshphpl.ssps...........t.tchlpchh..pph...................hp.ch.lhphh.-ulhhGaushEl...a..............thps.........th.hh.ttlhh+s....p...h.F...t...hs..p.s.t...................h.hphp.ss....................G..........l..s...hta.lhth.hp.upts.....t.uLhphhha.hhhKphulc.ahpFhEh..a..G..h..Phh...lGKhss...ss.....spp-hpp..............L...hpu...ltp...h..s.ps..u..u.ul.......lPp.............s..............p.............l..-....hhpsss......sssssa..p..ph.hcat-pplu+slLGpsl..T..op....spsuohAhupsHp-.....Vpp-lhpuDsc.lttslsptll............h.......hhtlNh.........sspthP.ph.htt...p...-s.tD.....hpt............hupth.p.L.s.s.h.G.h.p.lst.....pal....pcph.slststtt.p.thht....s......................................................................................................................tp..hpthhtth...........htt..ht.hht.h......th...ht....t.ts..tth.......t......tl.............t.h..phs.tth.......p.ht.hh..uph.G..................................................................................................................................................	0	39	71	83
+5903	PF06075	DUF936		Plant protein of unknown function (DUF936)	Moxon SJ	anon	Pfam-B_10047 (release 9.0)	Family	This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	20.10	20.10	21.60	20.80	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	580	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-13.03	0.70	-5.59	13	173	2009-09-11 12:47:55	2003-05-28 15:22:28	7	4	21	0	122	161	0	420.20	24	96.01	CHANGED	LsPGVLhKL.Lp..sMsos.lK..ssGEHRSu......LLQVhsIVPA.Luuu...-LaPspG.FalKlSDSoHSsYVSLss.-csDLILSsKlQL.GQFIaV-+...L-suoPVPll+GlRPlP.GR+Ps.VGsPcDLhusc..s.hpt.........................................................shppp+tssssRphshssss+p......................shsuSPssht.h.hshp..................phsptpsuhhhsup..hptsSPsstppsss........t...................Guuph+Kpssshst............stpsps+s.stppssttpsssspsPs+sp............ptth.tthpchshsssspssspospppss...t...................p.hphsstslsWsSLPssLs+LGK........EshcpR-sAthuAlcALcEAoAsEsll+sLptFoELop..suKt-sPtssl-pFLphappltpsphh.hpSlststsssstsp.......................pppsuhp.lpu...AlsTshsshslh...........................................ppp.sshpph..sth.pptppspsstpt..............ptsGls-oscLAppLppEupsWFLcFlEcuL-pG.hctp.............ptpssuclut......hLSQLKpVscWLDplsssppp..................-pl-pLR+KlYthLLpHVposAuulss	....................................................................l.sGlL.+l.lp...t.pss..p......sphRss......lLQVhtllPh.lstt.......p.h...tp.G.FhlplSDu.+uhYsp.s..tpt-hll.ssp.pl.Gphhalp+...l..p....u.PVPhhhsh+sls.tRt...h..hGs..Ptshh.........................................................................................................................................................................................................................................................................................h................t.............................................................................................................................................................................................................................................................t.........slss..l...up.....................thhp.+p.A..huhpu.p-A.hsp.llp.hp.auplp...ssp.tss..hhp.tFhth.t.h.p..h................................................................t......tt.t.....................................................................................................................................................................................................tthtt.hpLt..l..-.ttWFhtalEthL-.t..th......................ttpht.............hhps.pWlp..................................................................s...............................................................	0	14	78	104
+5904	PF06076	Orthopox_F14		Orthopoxvirus F14 protein	Moxon SJ	anon	Pfam-B_10072 (release 9.0)	Family	This family consists of several short Orthopoxvirus F14 proteins. The function of this protein is unknown.	21.90	21.90	22.40	125.40	21.00	17.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.50	0.72	-3.92	2	33	2009-01-15 18:05:59	2003-05-28 15:26:25	7	1	19	\N	0	20	0	72.90	86	100.00	CHANGED	MKH+lYSEGLpISsDhNSIIuQ.ST.DhDIEIDEDsIhELLNILTELGCDVDFDEsFSDIsDDlLESLhEQDh	MKHRlYSEGLuISsDLNSIIuQQS....ThDhDIEIDEDDIMELLNILTELGCDVDFDENFSDIADDILESLIEQDl	0	0	0	0
+5906	PF06078	DUF937		Bacterial protein of unknown function (DUF937)	Moxon SJ	anon	Pfam-B_7321 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	24.40	24.40	24.40	24.80	24.30	23.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.90	0.71	-3.94	89	984	2009-09-10 15:56:24	2003-05-28 15:43:14	6	6	888	1	262	664	43	125.00	30	71.04	CHANGED	l-plhu....t..htt............................hsthlGh.....................................................ssspsssuh..ssh..lssll.......uuh......ttt.sts..................................sGhsu........................Lhstlppssh......................................ssthtshlu..su.s.sh.............usshlsplhsu....psshsplupp...oGlst..spltphLshhhPhllshLssp	.................................................h.........................................................................................................................................................hstl..l.........Guh.....tt........t..ts...................................GGlps........................LlppL.ps.u..G.L....................................Gshl...s...o..Wlu....ptsNpsl...............uscp.Lpssl.G.....ssslssLup.+.........hGlss.spssshLuphLPpllDtLoPp............	0	53	152	207
+5907	PF06079	Apyrase	SHAPY;	Apyrase	Moxon SJ	anon	Pfam-B_7593 (release 9.0)	Family	This family consists of several eukaryotic apyrase proteins (EC:3.6.1.5). The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate. [1]. 	20.30	20.30	20.50	35.50	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.87	0.70	-5.26	20	238	2009-01-15 18:05:59	2003-05-28 15:48:53	6	4	129	8	104	237	2	249.00	43	77.24	CHANGED	LDpsStspcct..soWtShl++GpLphsssppslolcW-pt.pltlpS+huhKGRGMELSELlsFNGKLYolDDRTGllYcIpcs..cllPWVILsDGDGsssK...............GFKuEWsTVK-ppLYVGShGKEWTTosGphhNpNPhWVKsIshcG-VpphNWhspYcplR.sAhGIpsP.GYlIHEussWSsptppWaFLPRRsSpEpYsEptDE+pGsNhllousEsFpclcslcls..shsPs+GFSSFKFlPsTcDplIlALKopE.....csGp.sATYlosFsl-G+lLLsEp+I.sDsKYEGlEFl	................................................DptSt..t.p.tp..poahShl+hG.Lphs.......s...............s.t.plslch-.t...phhlpo.....phu.pGRGMELSELlhFNGKLYohDD+TGllac..l..ct......s.........c.........hlPWVILs-GDGs.s.p.K.....................................GFKuEWh...TVK.--cLYVGuh.....G+EWs.sspGphlspsshWVKhl.shpG.cVpphNWsspYptl+.p.AhGIp.P.GY.hhHEus.WSthhppWhFLPR+sSpp..Ys-t.DEp.h.GsN.hll.ss.t.sFtp.lp.s.pls.....h..st+GFSuF...........KFlPs....opDplIlALKo.E..........tsp..htoalhshsl.p.G.......phlh.-........p.l.ts.KaEGltFh..........	1	48	57	86
+5908	PF06080	DUF938		Protein of unknown function (DUF938)	Moxon SJ	anon	Pfam-B_8833 (release 9.0)	Family	This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. The function of this family is unknown.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.24	0.71	-4.78	6	529	2012-10-10 17:06:42	2003-05-28 15:51:31	7	5	465	0	233	728	387	188.80	39	90.05	CHANGED	+.aAPAspRN+-PILuVLpphlssssp...lLEIASGTGQHAsaFAsthPshpWQsSD.spphht.SItA....atcptulsNltsPlpLDlots.hsspt.h..........ssslDulhshNhlHISPWsss.GLFsGAGclLsptulLhlYGPYspsGchTusSNtsFDpoLRsRsspWGlRDlc-lhuLAtppGLpLpchlsMPANN+sllFp+	..................................husAs-RN+pP..ILp......V.L...pp...h..l....sss.sp..........VLEluSGTGQHusaF..At.th..........P......t..l....p.WQ.P.S.D.hstpt....ht...........SItA.............ah..t.p......s.....s.l..s.N.....l.t.s.P.l..t.L...D..ls.ts....a.sht..................................................shDulhsh..N.h.l.HIs..sas.s...s.pu.LFtuA..u............p.hLt.s........s..Gh.L........hl.YGPaphs.GphT.ut.SNttFD.t.pL+p+.s.P.t.h..Gl..RDhc.s.lttLAttpGLt......LtchltMPA..NNhhllap+........................................................................................	0	62	122	184
+5909	PF06081	DUF939		Bacterial protein of unknown function (DUF939)	Moxon SJ	anon	Pfam-B_8873 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.76	0.71	-4.31	33	2302	2012-10-02 19:04:43	2003-05-28 15:53:42	6	4	1115	0	242	2189	63	142.20	28	47.03	CHANGED	h+IGhRTlKTulussLAlhlAphL..sLs.hssAGIlsILslQsTppcSlpsuhpRhhuslluhlhuslhhtlhGa.sslshGlhlllhIslslpL+lp.cGlssusVlllplhsppshsahh.hhschhLlhlGlslAhLlNlaM	...............................plGhRTlKTulAshLu.h....l....l....s.t.h.L.............sl.s.....h....h.h....Au....l.s.A.l.l.u.l....p..s..oh.p..p.S..l.p.hu.hsRlhush...lG..shlu...l....l.....h......h...h.....l............h.......G........p.......s.......h....h.......s....h......u.....l....h...........l.....h......l......h....I.....s...l......s......h.......t.......h.......p........l........p........t...........G........l..........s..........s..........u..........s.....l....h........l....l..........t...........l.....h..........s..........t..........p..........s......t..........s..........h..........h....h......h....hsc.h.lh.hhIGlhh.AhllNhhh..................................................................	1	87	155	210
+5910	PF06082	DUF940		Bacterial putative lipoprotein (DUF940)	Moxon SJ	anon	Pfam-B_9128 (release 9.0)	Family	This family consists of hypothetical bacterial proteins several of which are described as putative lipoproteins.	21.10	21.10	25.80	24.90	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	658	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.83	0.70	-5.97	38	1147	2009-09-11 20:50:12	2003-05-28 16:06:17	6	5	706	0	120	707	920	573.90	47	92.49	CHANGED	sS.ssaGss.GLlpMPoARMts-Gphuhshsts.........sp..........Yp+asholQlhPWlEsohRYopl......psh.as.........s.h..SGsppapD+uhDhKhRLh..cEota.lP.plulGlcDhuGTG............lFsGEYllAoKph...........Gsh-hTlGlGWGhlGspsslsssh......h..spRs.t...htspGGplshspaF+Gssuh.FGGlEYQsPaps.LpLKlEY-ussYpp-hssp.....shppcSs.aNaGshY+hschhclpLuYp+G............sTlshuholptNh.....sshpss.hhsssssshpsp......ssp..............................................................tshpss...........................hpphhpphhtpsGaphtplt.hcss..slslthc..p.s+YcspscAhtRsApllusshPss.lcpa+ll.pptshPhsps..............plct.tthpshtphphh..s.sphtstsphsps...h.sps......thhppth.ca....sauluPhlsQShGsP-shahaslGlpssusYphssshhlsGslthslh..sNaDchph.............................sus.sLPRVRT.hRpYsppssspLspLpLsahtphupshYspshuGYLEpMauGVGuElLY+P.hsusaAlGl-hNal+QRDh...-shhGh.............t-hcs..........................hT.......G...HsosYap.s.....pshhhplssG+YLAsDhGsTlslu+pFcsGlhlGAaAThT...DlSu-EaGEGSF.sKGhalSIPhDhhhscPopspushshtPloRDGGQhLspphpLY-hTcsp	...........................................................SQSDFGGs.G.LLQhPoARMA.EGEh.SlNY+DN...............DQ.................YRaYSsSVpLFPWLEsTlRY..T..DV...RT+pYS........phEsF...SGDQoYKDKuFDhKLRLW...EE...u...YW...lP.QVAlGtRD.I...uGTG.....................LFD.uE....YlVASKth...........GPF.DF.T..LGhuW.GYhGsuGN.lpNPhCp.....hSD+aC.Rs............pp.AGslsh....SphF+GP.A.Sl.FG...GlEYQ.....T....PWpP...LRLKLEY-GNsYppDFA.G.........+L.QtS.+..FNVGAlYR.s.s.sW.ADlNL.SYERG............N.ThMFGhTL...RTNF.....NDLRPs..hpDss+PtYpPt.....Ppsth.......................................................................phos......VAsQLThLKYNAG..htsPpIQ..h+s...c.....TLYhoGpQ..hKY.RDo+Eul.RA.NRI.lhNsLPp..........G.l...........cpIplT.pp.R..s.hs.VTT.....................ETDV.ASL+p...pLsGps....t...........hp.tp.p.h.s.......puht...............................pGahIccsRa.....saphsPs..LsQSl.GGPEsFYMaQLGlhuoAchWhTDHLLh..sGulFsNlh..NN.YDKFp...o.........................PtDS.pLP.RVRT+lR-YV..pNDVYlNNLQANYFtcLG...N.GFYGQVYGGYLETMauGsGuElLYRP.lDusWAhGlDsN.YVK.QRDW...csM.M+F..............T.DYSs..........................hT..........G...alTA...Y.WsPs.....hhpsVLhKhSVGQYLAtDKGuTl-luKRFDSGVsVGsaAslo...sl..St--..Y.GE.Gs.F.o..KGhYlSlPhDLho.sPsRsRAsluWoPLTRDGGQ.LuR.KapLYsMTu-...........................................................................................	0	24	69	97
+5911	PF06083	IL17		Interleukin-17	Finn RD	anon	Pfam-B_9152 (release 9.0)	Family	IL-17 is a potent proinflammatory cytokine produced by  activated memory T cells [1]. The IL-17 family is thought to represent a distinct signaling system that  appears to have been highly conserved across vertebrate evolution [1].	21.00	21.00	21.70	22.70	20.90	20.30	hmmbuild  --amino -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.09	0.72	-3.92	20	312	2009-01-15 18:05:59	2003-05-28 16:46:01	6	4	67	10	176	271	0	81.80	39	48.52	CHANGED	pRSlS..PWsYpls.......cDssRYPphlsEAcCLCpGClsup.GcEshsh.sSVPlhppllVLRRp............spssstuachchhpVsVGCTC.Vh	......pRSlSPWsY.pls.......pDs.sRaPp.ls-ApCh.CpG..C..l.......s....s......Gp...c.s..tsh..sSlPlhpphhVLRRp.............spssthsachchhtVsVGCTC.V................	0	39	51	81
+5912	PF06084	Cytomega_TRL10		Cytomegalovirus TRL10 protein	Moxon SJ	anon	Pfam-B_8875 (release 9.0)	Family	This family consists of several Cytomegalovirus TRL10 proteins. TRL10 represents a structural component of the virus particle and like the other HCMV envelope glycoproteins, is present in a disulfide-linked complex [1]. 	20.20	20.20	21.20	260.60	19.20	19.20	hmmbuild  --amino -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.96	0.71	-4.41	5	22	2009-09-11 05:08:22	2003-05-28 16:48:09	6	1	6	0	0	21	0	149.10	91	87.75	CHANGED	VCAETTVATNCLVKTENTHLTCKCSPN.......sTSsTGNGSKCHAhCKC.RVTEP...ITMLGAYSAWGAGSFVATLIVLLVVFFVIYAREEEKNN.TGTEVDQCLAYRSLTRKKLEQHAAKKQNIYERIPYRPSRQ.KDNSPLIEPTGTDDEEDEDDsV	.VCAEsTVsTNCLVKoENTHLTCKCsPN.......soSNTsNGSKCHAMCKC.RVTEP...ITMLGAYSAWGAGSFVATLIVLLVVFFVIYAREEEKNN.TGTEVDQCLAYRSLTRKKLEQHAAKKQNIYERIPYRPSRQ.pDNSPLIEPTGTDDEEDEDDDV	1	0	0	0
+5913	PF06085	Rz1		Lipoprotein Rz1 precursor	Moxon SJ	anon	Pfam-B_8925 (release 9.0)	Family	This family consists of several bacteria and phage lipoprotein Rz1 precursors. Rz1 is a proline-rich lipoprotein from bacteriophage lambda which is known to have fusogenic properties. Rz1-induced liposome fusion is thought to be mediated primarily by the generation of local perturbation in the bilayer lipid membrane and to a lesser extent by electrostatic forces [1]. This family Rz1 and the Rz protein Rz (Pfam:PF03245) represent a unique example of two genes located in different reading frames in the same nucleotide sequence, which encode different proteins that are both required in the same physiological pathway [2].	27.90	27.90	28.50	32.30	26.60	27.80	hmmbuild  --amino -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.23	0.72	-4.54	7	97	2009-01-15 18:05:59	2003-05-28 17:12:01	6	2	60	0	3	60	0	40.80	57	61.59	CHANGED	CsSpPss...C...lKPPsPPAWhMpPssDhpp.LNtIhSsScpp	...........CtSsPPV......C...scPPsPPAWhMpPssDhQp.LNuIISsSEst...	0	2	2	3
+5914	PF06086	Pox_A30L_A26L		Orthopoxvirus A26L/A30L protein	Moxon SJ	anon	Pfam-B_8938 (release 9.0)	Family	This family consists of several Orthopoxvirus A26L and A30L proteins. The Vaccinia A30L gene is regulated by a late promoter and encodes a protein of approximately 9 kDa. It is thought that the A30L protein is needed for vaccinia virus morphogenesis, specifically the association of the dense viroplasm with viral membranes [1].	21.00	21.00	21.00	22.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.75	0.70	-4.88	3	96	2009-01-15 18:05:59	2003-05-28 17:20:21	7	2	32	0	0	88	0	208.20	60	42.94	CHANGED	MANIINLWNGIVPTVQDVNVASITAFKSMIDETWDKKIEANTCISRKHRNIIHEVIRDFMKAYPKMDENRKSPLGAPMQWLTQYYILKNEYYKTMLAYDNGSLNTKFKTLNIYMITNVGQYILYIVFCIISGKNHDGTPYIYDSEITSNDKNLINDRIKYACKQILHGQLTMALRIRNKFMFIGSPMYLWFNVNGSHVYHEIYDGNVGFHNKEIGRLLYA	...........MANIINLWN...GI.VPhVQDVNVASITAFKSMIDETWDKKIEANTCISRKHRNIIHEVIRDFMKAYP.KM.DEN.........+KSP.LGAPMQWLTQYYILKNEYaKTMLAYDN.....G...SL.NT....KFKTL.NI.Y......M..ITNVGQYILYIV.FCIIS.GK.NHDGTPY...I...YD...SE.ITSN.DKNLIN-RIKYACKQILHGQLThALRIRNKFMFIGSPMYLWFNVNGSpVYH-IYDtNsGFHN+EIGRLLYA........................................	1	0	0	0
+5915	PF06087	Tyr-DNA_phospho		Tyrosyl-DNA phosphodiesterase	Finn RD	anon	Pfam-B_8155 (release 9.0)	Family	Covalent intermediates between topoisomerase I and DNA  can become dead-end complexes that lead to cell death. Tyrosyl-DNA phosphodiesterase can hydrolyse the bond between  topoisomerase I and DNA [1].	22.00	22.00	23.00	22.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.78	0.70	-5.86	27	520	2012-10-02 13:01:53	2003-05-29 09:34:23	7	27	273	43	378	517	1	347.80	22	66.87	CHANGED	Phplhhoslhshpsp.......tsssslsLc-lLus...plppsh.a....sFhhDlsaLlsphs.phhp...plhhlpG...ppt.phhphttt.....th.NlphltsthstsF...GsHHoKMhlhhac-s....h...+lVl.osNhh.tDWs.....hsQshWhSshl........spsssst.........stscF+p-LhpYLppYt......tsl....hpplccaDFSsl...sstLlsSsPGpap.........ph..p..aGaspLtplLpcpss.s......tpspphsl.lsQsSSIGolsss.t.ahpsphhssLhhss...............................tt.ppppsphpllaPoscpl+sShs.GasuGuslha+hp....p+ppp.hl+..shhp+Wtup............sptRspshPHlKsYh+hs..........pphpslpWhllTSANLSpsAWGs......htptssphplpuaEhGVLh......Ppths..................h.shshpts..t.....................hth.hPac.lPhpsYs	............................................................................................................p..slplp.-llt.....l..sh......sahhDhtalhtth....th..h.............lhh.lh..s.........t...t.t..th..t.......................h..plphh.s.h......h...........ushHoKhhllh....htpt..........h...+lll.ouNhh........DWtp..............hpps..........lahpsh...Phh.............tttt................................p.stFpt...cL.htaL.tht........t.h.................hp.l.p.p.h.Dauts...pshhltSsPGhat.....................................p......hGhhtLtphlpphs............................p.....h..l.......hQh...SSlGs.....h............tthhp..sh..............................................................................hpllaPo.pplpp.Sht..G...h.....u...u.s.s.l...........hp..........p.............t.......hlc.......h........h..t.................................................ttRptsh..s.HhK.....hhhths.............................................t...pph.sWhhls..SuNLSpsAW.Gt................................p.ttsph.lpsaEhGVlh........Pt.ht......................................................................................................................h.hPh..hs.............................................................................	0	116	204	316
+5916	PF06088	TLP-20		Nucleopolyhedrovirus telokin-like protein-20 (TLP20)	Moxon SJ	anon	Pfam-B_7657 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus telokin-like protein-20 (TLP20) sequences. The function of this family is unknown but TLP20 is known to shares some antigenic similarities to the smooth muscle protein telokin although the amino acid sequence shows no homologies to telokin [1].	23.50	23.50	23.60	26.50	22.30	23.40	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.04	0.71	-4.58	21	50	2009-01-15 18:05:59	2003-05-29 09:38:37	6	1	47	1	0	53	0	192.40	31	97.19	CHANGED	MAossssTsD.IsVpsplsc-.tccslLsFhlc-EY+LpKhulGAaslpllsop.LssLtpstp..sslssG-YsllaNhsps.spplsslLhslKssslKKusslF+lhhhs................................................ophhhsuss............sppsspsps---s..................sss-shshsts................ssssssK+QKLDcptps	......MAossssTsD.IuVaspl-cE...tscs..lLoFlVc-EYHLKKLuVGAYslsIl-oph.LssLtp.ptp......ssluCGsYllhaNhscp......sstlNsILFNh+.sshLKKusslF+lhahs.............................................................................................tptpsphhtss.s...........sppsspsps---s.......................psss-ssshsts.........................t.stssssK+QKlDcs......................................................................................	0	0	0	0
+5917	PF06089	Asparaginase_II		L-asparaginase II	Moxon SJ	anon	Pfam-B_7673 (release 9.0)	Family	This family consists of several bacterial L-asparaginase II proteins.  L-asparaginase (EC:3.5.1.1) catalyses the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by asparagine and repressed by the carbon source [1].	25.00	25.00	34.20	34.10	24.50	17.90	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.82	0.70	-5.75	87	514	2009-01-15 18:05:59	2003-05-29 09:45:46	7	4	476	0	211	516	948	313.30	37	94.11	CHANGED	hlclhRGu...................llEShHpGpsVVsDscGp......llhthGsssps.sasRSuhKPhQALsllpoGAspth.........................................slsscc.LALsCASHsGpshHsctstshLtchGLs-ssL......pCuschPhst.st.thhtsstpPstlppNCSGKHAGhLssspthGhshcsYlpscHPlQptltpslp-lsuhss..sph..uhDGCusPsaAhsLpslApuaAphAsu...t.t...s.t.pttsht+lhcAMttaPphVAGpGRhsTpLMcshsGplluKsGAEGVhssul..........sstGlGlAlKlpDG.usRAttssssplLtplsh..........l....sss.hstltphhtsslhst.pGh.sGpl+ss	.................VclhRGs...................hlEShHpGpssVlDs.cGp......llhshGDscps.sasRSuhKPhQALsllco....Gsspth.........................................shssp-LAlsCASHsGE.tHlptstshLtcs..G.....LspssL......pCsschPhpt.sh...thhps.stp...PoslppNCSGKHAGhLAs.stt...........t...........G...........h......s......h...............csYlp.sHPlQ....ptltpsltclsGhsh..sth...GhDGCusPsaAlsLpsLA+uaAphAsu...........t..s........s.t.tttshpRlhcAMtsaPthVAGs.sRhsTtLMctssGtlluKsGAEGVhshul..............sc...G...hGlAlKlpDG..u.sRAttsssstlLpp.Lsh..........h...s.s...t.ttLtpht..p..s.....hhst....tGh.lGplp.s................................................	0	69	144	187
+5918	PF06090	Ins_P5_2-kin	DUF941; 	Inositol-pentakisphosphate 2-kinase	Finn RD	anon	Pfam-B_9098 (release 9.0)	Family	This is a family of inositol-pentakisphosphate 2-kinases (EC 2.7.1.158) (also known as inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase) and InsP5 2-kinase).\	 This enzyme phosphorylates Ins(1,3,4,5,6)P5 to form Ins(1,2,3,4,5,6)P6 (also known as InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, nonhomologous end-joining, endocytosis and ion channel regulation.	22.70	22.70	22.80	23.30	21.70	21.30	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.34	0.70	-5.39	38	330	2009-09-11 15:15:53	2003-05-29 09:47:06	7	11	270	17	238	346	0	342.40	19	82.54	CHANGED	YhuEGsA...Nllhphssss..............................hht+lLRlcKhtts................................ttpppchhcahc..phl+..PLhu....p.lsstplVtls..pphlppl..spplp.........................Rst.R.th...hlssscshuLLlsDlsshst....................................................sslslEIKPKWha...............................p....hpsphCRhCshpthK..................t.tthsptppaCPL...DLh.....usshpclhpAlcs.hsp......spssh+h.htt..........................................................lschLhp...............................................sslLp+LhphQc........................................................ts.pthshpth.shspphtluMTh+DCohhIphp.pt............................................h.hpsplhDLDhK..shpKhppah.ch-pcL	...........................................................................................................................................ahuEGssNllh...thtt..t.......................................................hlLRhhKh..s................................................p..pahp....phhp....hhs..................phlhs..p..lltls......hphlptl..st.lt................................R...+hth..........hs.htpshuhhlsshs..hs...............................................................................................................................................tsshslElK..PKhhh........................................................................................t..t.hptphCRhChh...phhK......................tt..tt...hpp..ppaCPL-Lh.....................uss.hpchhtAlpthhtp.......................spssh+h..tt..............................................................................................hthltphLhp..............................................................................................................................................................................................sslLtcLhp.h.Qt.......................................................................................................................................................................................................t...t.p..ths.h.tt...p..h......pp..hhluhTh+DColhlphp.tt..............................................................................................................................................hpsplhDLDhK..shtph.hah.ph-tp......................................................................................................................	0	82	128	193
+5920	PF06092	DUF943		Enterobacterial putative membrane protein (DUF943)	Moxon SJ	anon	Pfam-B_7843 (release 9.0)	Family	This family consists of several hypothetical putative membrane proteins from Escherichia coli, Yersinia pestis and Salmonella typhi.	25.00	25.00	25.10	28.50	23.20	24.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.11	0.71	-4.93	16	442	2009-01-15 18:05:59	2003-05-29 09:58:29	7	2	256	0	34	201	0	148.80	46	96.19	CHANGED	MKp+pptllh...ullLhuslh..YhhW.thRPVEI................lsVHpcss......stIlV+sFPlTD+GKIsWWhcNKshLKpKYsIPcss.cGhaolhhWDFG-GYc...........cpupsDhhCF-DhK.opcNCI-K.Nhlhslcphp.ssphhFshssspY.hp.........csGclsK..htp-	.................................MKtc.pKllh...sLhLlssl....Y.hW.phRPVpI................lhsapDss.....sshllVcchPhTDpsKINWaLcppsclKspaslPcsu.csaasI...DhGsGap...........EtshpDLhCFsshK.os-NCIsK.NhLMsIpch..cNshha.hh....DtspYQLs.........ppsKIp+shp.s............................	0	5	16	23
+5921	PF06093	Spt4		Spt4/RpoE2 zinc finger	Moxon SJ, Kerrison ND, Finn RD, Bateman A	anon	Pfam-B_7906 (release 9.0) & COG2093	Domain	This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2 [2]. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [1].  RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in [3]. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.	25.00	25.00	27.10	30.20	24.40	23.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.85	0.72	-4.10	37	482	2012-10-03 10:42:43	2003-05-29 10:20:38	8	1	446	10	332	435	72	70.90	37	68.11	CHANGED	hRAChhCpllpohspF..pGCsNC..hhtht.ts.pplt-sTSpsFcGllulhcPpc.SWlA+a.c.lsphhPGhYAlpVs	...........RAChhCpllp..ohsp....F.....p.....GCsNC..hh.t.....ts.t.....s.csTSssFcGllsl..hcPpc.SWVA+a.p....l....sthhsGhYAlpVp..............	0	105	189	271
+5922	PF06094	AIG2		AIG2-like family	Finn RD	anon	Pfam-B_9771 (release 9.0)	Family	AIG2 is an Arabidopsis proteins that exhibit RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2 [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.73	0.72	-3.52	90	2098	2012-10-02 16:39:48	2003-05-29 10:21:23	7	27	1701	10	779	2120	898	101.30	28	64.81	CHANGED	lFVY...GTLpps.psppthlt.........tsphhspsspht.......hhhhthtsYPsll............ssst................................tVpGp.lapl...sp....pt..LptLDphEt.......pss.hYcRtplplt.............hssstt............pAalYhhp	..................................................................lFVY...GoL..ppt...pss.p.phht....................ssph.h.u..p.h..t..hht..........h..h.h..h..s...h.s.t..Y...P..uhls.......................sss........................................................pVpGE..V..Y.p.l.......ss..............sp......LspLDthcs.................psstYpR.p..h.lp.s.........................................hs.......................pAahYlh...........................................................................	0	261	470	649
+5924	PF06096	Baculo_8kDa	Baculo_8Kda; 	Baculoviridae 8.2 KDa protein	Finn RD	anon	Pfam-B_8370 (release 9.0)	Family	Family of proteins from various Baculoviruses with undetermined function.	25.00	25.00	36.30	35.80	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.29	0.72	-4.09	15	32	2009-01-15 18:05:59	2003-05-29 10:31:12	6	2	30	0	0	25	0	64.50	44	78.56	CHANGED	ssYslppFYNssR+PLKsTTLHsGNIspssYEsVhhhR..+LhC+Esh..Puc+-hpFps.+saNKEN	......s.slppFYNssRpsLKsTTLHDGNlstpsYcsVh.sR...+LhCpEsh..suc+-hKhpp.psaNKEN...........................	0	0	0	0
+5925	PF06097	DUF945		Bacterial protein of unknown function (DUF945)	Moxon SJ	anon	Pfam-B_9171 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	22.40	22.40	22.50	24.10	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	460	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.37	0.70	-5.71	50	1334	2009-09-11 15:55:27	2003-05-29 11:00:00	6	4	964	0	145	797	18	449.70	33	95.70	CHANGED	MKK...hhhGlllulsslhsuusaasGpphEsphpptlsphNt.........sssl..plphhsacRGhFSSpsphplpssssthpt.............shplshssplpHGPhshsp...lpphphhsthh.sp.......sthhp.hhthhtspsPhphssplsasGssssslslsshsh....ptssssls...auGsphphshs.pshpphshpsshsslplsh...........sttplplsslphs.sstptsphs......hhlGspshplcplslssp...............................spphhplpshsht.psphsp........ss...splsuphshslsslphssp.slGssplshplsplDupuhpphhphYpspst..................s...hpptthpplhsslstLLpssPplslssLohcs.spGchshsls..lsLsss..sptttts.......tplhp..shphssphslstshlschht.......................................ph.t..ts.........................t.uppplpthsshhhh.plhs.cssslpsshphssGplsl.NGpch...Pltph	..........................................................MpK....sAsGVIlALull..WsG.GsWYT.GpplE.splpch....lpphNtth+.........hst.psslploYpNacRG....h..FoSphQhhl..p..sut.s..lc..............................sGQpllhspsVcHGPhPlst...Lt+hN.....llPuhAuhpspL.........sNN-hspsLF.ths..K.s.cs.Phphss..Rh.u....a..u.G.ss.so........slslt..PhpY......pptstKlu.....F.usup.hphsuD...pshp.s...l...s.lpGcs.pshhlshs....................................ptsplohpslphD.upuphspht.......hhlG.pp.chplpp.hsIssc...............................Gcchs..l-uhp..hpscoch..sp...........Dt....ctlNspLsYpLs..s..Lph.....p.........s....p.....p....L......GS....Gcl....oLtssplDupA...h+QF.ppYsttspt.h....................tsthups..hhQpt.s....sp.t.......hhstLPhLhcucPslslsPluWKN..upG.E......shNLs..l.ltDP.....upsptss...............sp.hc.....lKoLshcl..plPh.shsoEhhpQhs..............................................................................h..EGh.pt-pAp................................+hAcpQlp.u...h...shGQM..hpLhT..l...p..sN..slshp.L.......pYss..Gplsh.NGQcM...s.E-F...................................................................................................	0	32	63	112
+5926	PF06098	Radial_spoke_3		Radial spoke protein 3	Moxon SJ	anon	Pfam-B_9453 (release 9.0)	Family	This family consists of several radial spoke protein 3 (RSP3) sequences. Eukaryotic cilia and flagella present in diverse types of cells perform motile, sensory, and developmental functions in organisms from protists to humans. They are centred by precisely organised, microtubule-based structures, the axonemes. The axoneme consists of two central singlet microtubules, called the central pair, and nine outer doublet microtubules. These structures are well-conserved during evolution. The outer doublet microtubules, each composed of A and B sub-fibres, are connected to each other by nexin links, while the central pair is held at the centre of the axoneme by radial spokes. The radial spokes are T-shaped structures extending from the A-tubule of each outer doublet microtubule to the centre of the axoneme. Radial spoke protein 3 (RSP3), is present at the proximal end of the spoke stalk and helps in anchoring the radial spoke to the outer doublet. It is thought that radial spokes regulate the activity of inner arm dynein through protein phosphorylation and dephosphorylation [1].	23.80	23.80	23.80	24.10	22.50	23.70	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.73	0.70	-5.41	14	179	2009-01-15 18:05:59	2003-05-29 11:14:06	6	7	117	0	124	177	8	265.80	39	61.68	CHANGED	hsY........uNIMaDRRVhRGNTYutp...h.up.-.........pppppuppcuhs+K+t+phhss+.........oPsss-GRcphsVQTE.YLEELpD+l...Es-h-sQTDsaL-RPsoPhaVPtKoGtDstTQI..-.....GELFDFDhEVcPIL-VLVGKTlEQALlEVhcEEELtplRppQcpa-phRsAELsEsQRLEtpE+RppcEKERRhpQc+pthcc-+EspcKlsARsFApsYLu-llssVhssLcspGaahD.lcp-lEpsFhPWLhpEVtppltpp....h.u+slLDplIc-lsp.ph.thhptpp	.........................................................................................................htNlMaD+RVhRGsTau.....h.....s..p...p.h.....................ppp.pptp++shs+..Kptpp...h...p.p.........TP.PlcGRpHhslQTE.hY..LE..ElsD+h...Eh-h..-sQTD.sFL.D+PsTPh........FlP.........sKoGhDsuTQI...-.....G-.LFDFD.hEVc.PlLEVLVGKTlEQuLlEVhEEEELssL+tpQptacphRssELsEsQRLEtp.E+Rpp-EKERRhpQphphhcpcpEsppKlsApshAptY.lusLlssVhssLc.spGaFhDslcc..-lEhsFhPWLhp-Vtpphppt....hhuRp....lL.......-.llpplhppp........t................................................	0	65	76	101
+5927	PF06099	Phenol_hyd_sub		Phenol hydroxylase subunit	Moxon SJ	anon	Pfam-B_10062 (release 9.0)	Family	This family consists of several bacterial phenol hydroxylase subunit proteins which are part of a multicomponent phenol hydroxylase. Some bacteria can utilise phenol or some of its methylated derivatives as their sole source of carbon and energy. The first step in this process is the conversion of phenol into catechol. Catechol is then further metabolised via the meta-cleavage pathway into TCA cycle intermediates [1]. 	25.00	25.00	32.80	32.30	17.90	15.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.70	0.72	-4.14	23	83	2009-01-15 18:05:59	2003-05-29 11:20:04	6	1	69	0	24	79	5	58.60	42	70.33	CHANGED	pstP..sh-hp.p+YVRVpucpssuFVEF-FuI.GpPELhVELlLPpsAFctFCtsNpVhcLss	......p..s..h-.h.p+aVRVpucpsssFVEF-FuI.GcPELhVELlLPpsAFcpFCptppVhphs........	0	1	13	22
+5928	PF06100	Strep_67kDa_ant		Streptococcal 67 kDa myosin-cross-reactive antigen like family 	Finn RD	anon	Pfam-B_9995 (release 9.0)	Family	Members of this family are thought to have structural features in  common with the beta chain of the class II antigens, as well as myosin,  and may play an important role in the pathogenesis[1].	23.00	23.00	23.00	23.00	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	500	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.63	0.70	-6.15	8	1128	2012-10-10 17:06:42	2003-05-29 11:20:18	6	6	924	0	207	793	40	447.70	47	85.31	CHANGED	-sKSAYlIGoGLAuLAAAsFLIRDGQMsGc+IHILEELslsGGSLDGhphschGYVsRGGREM.ENHFECLWDLFRSIPSLEhsssSVLDEFYWLNK-DPNaSpCRlIcKpGpRlDsDGcFTLopKuhKEIhcLhhTsEEcLsDhpIc-lFS--FFsSNFWlYWpTMFAFEsWHSAhEMRRYlMRFIHHIuGLsDFSALKFTKYNQYESLVLPhlpYLKsHuVsFcYsspVpNIpVDhosuKKlA+pIhhp.+sGcccoIcLT.sDLVFVTNGSITESSTYGssspPAPhTcEL..GGSWpLW+NLApQSs-FG+P-KFCpclPppsWhhSATlTscsc+I.sYIE+ls+RDPhuGKsVTGGIlTlpDSsWLhSaTIsRQPpFKcQscN-lllWlYuLYSDpcGDYIKKPhcECTGpEIspEWLYHLGVPp-cI--LA.pcssNTIPVYMPYIToYFMPRshGDRPhVVPcsSsNLAFIGNFAET....sRDTVFTTEYSVRTAMEAVY	....................p+pAYllGuGlAuLAAAsaLIRDupMtGppIpI..l..E.ch.......s..hs....GGS.h.....D.....G....t...............t...............................s.............p..cGalsRGGREM...-.pHF..EshWDLa+oIPS...LEhs.s.hSVLDEa..hh..l..s....c...c....D...P..s..h.u...p..sR...................ll....c..p..p..G...p...c.....h...s...s..s.uphsLspps.h-lhcLhhss...E...-...cLtshpIp-hF..s.-..-..FFpoNFWhhWpT.MFAFE.WpSAhEh+RYhhRFlaal..sGlschouL+FT+YNQYEShllPhlpaLcspGVpFpass....pVpslp..h..c..h..s...s..s.....p......K......l.....A.p....p...I.hhp....p...s.......G.........p...p..............c...pIpLs.sD..L..VFlTNGSlTEuoohG.Dp.so.......P.....A.....s...............s......p..-h.....uuuWpLW+plAp.....p..s......s..p..FGpP-hFsp.....shscpsW..hShThTs..p...s.p.p.l.h.shI.cplsppcP...hsG...p.hsTGGIlThpDS..sWhhShslsRQPpF+sQs.c.sphssWhYuLascp.Gsal+Kshh-CTGpEIhpEhLYHL.......Gl....s.......p.......p...p......h......cclu..t.......p.tssslPshMPYITuhFMsRshGDRP.VlPcsShNLAFlGpFsEo.....cDsVFTsEYSVRTAM.AVY............................................................	0	53	115	164
+5929	PF06101	DUF946		Plant protein of unknown function (DUF946)	Moxon SJ	anon	Pfam-B_10066 (release 9.0)	Family	This family consists of several hypothetical proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	19.80	19.80	20.00	19.80	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	536	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.84	0.70	-6.51	15	441	2009-01-15 18:05:59	2003-05-29 11:22:46	6	38	192	0	316	436	14	234.70	18	27.46	CHANGED	s.spsFsLPusLPsWPpGpG.FAsGpIsL.GcLEVspl....osFp+VWsstputscstGsTFacPs.ulPcGFasLGaYsQPNs+PLpGaVLVA+Dluus................ssL+pPlDYTLVhsossht.spps.........sGYFWLP.PP-GY+AlGhlVTssspKPsL..DcVRCVRuDLT-pCEspshI..hs...ssu............hslassRPscRGhtupGVtVGTFhCpsts.ssc...sssIuCLKNlcss.LpuMPNlcQIcALIcpYuPhlYFHPcEpYLPSSVsWFFpNGALLa+KGcps...s.PI-ssGSNLPpGGsNDG..pYWlDLPsD-ps.+EpVK+GsLcSuclYVHVKPshGGTFTDIsMWlFhPFNGPAplKluhh.slsLu+IGEHVGDWEHFTLRISNFoGELWplYFSQHSGGpWVDAsDLEFhp........suNKPVVYSS+HGHASFP+PGhaLQGss..GlGIRNDsA+SchhlDooh+YcIVAAEYLGsulV..EPsWLpYMRcWGPplsYsscsElcplhphLPh.hLRhsh-sllpplPhELhGEEGPTGPKEKsNWpGDE	............................................................................................................................h.h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hGpHlGDWEH.hlRh........u................hahSt..H..t...t.Gt..h....h......t..h....p....h.............................+shhasu.tsHu.as..G.......................................................................................................................................................................................................................................................................................................................	2	86	186	267
+5930	PF06102	DUF947		Domain of unknown function (DUF947)	Finn RD	anon	Pfam-B_9959 (release 9.0)	Family	Family of eukaryotic proteins with unknown function.	23.00	23.00	24.60	24.40	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.33	0.71	-4.43	30	317	2009-01-15 18:05:59	2003-05-29 11:27:36	7	9	285	0	227	311	3	168.00	32	54.68	CHANGED	++psK+uPhEhSSK+.VsphRplhts..........p+s..hhRDPRF-....shuGp.............hs.shh++sYsFL.-DhRppElpclccpLccsK.....ss.......................cE+-cL+pplpshcschcshpp.+cpEpcllp-a++pE+-tlp.pGKp..PaaL..KKS.....-h+Khlhtc..Kacph..............cs+plcK.....hlE++RKKhsuKE+K	..................................+tsKctPhEhSoK+...Vsp..hRplhts............ppp.....hhRDPRFD.........shsGp.............hs..p...h.hcKsYsFL.s-h.RppEhpp...L.+cpL+cp+.........ss...........................................cc+cclcptlpphcsphpspcp.+cpcpclhpch++cc+ct..hc..pGKp..PaaLKKS..........Eh++hhLtp....+acph..............p.stpl-+hl-++RKKpsuK-++...........................	1	78	128	189
+5931	PF06103	DUF948		Bacterial protein of unknown function (DUF948)	Moxon SJ	anon	Pfam-B_10104 (release 9.0)	Family	This family consists of bacterial sequences several of which are thought to be general stress proteins.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.80	0.72	-4.12	42	1305	2009-01-15 18:05:59	2003-05-29 11:30:03	6	7	1253	0	178	574	36	89.90	36	61.21	CHANGED	IuslIhAlAFllLVlalhhsLtpl....pps...lppsspTlpslppplssltppospLLsKsNpLh-DlstKspslsPlhpAluDlupSVpcLNsu	....................lAulIsAlAFllLllall....hsLhpl..................p+s.......lDcsscTlc.......sls.......spV.......sslh...ccoscLLsKsNtLh...-D....lss.....KlsslsslhsAVsslupSVpsLNs....................................	0	49	111	147
+5933	PF06105	Aph-1		Aph-1 protein	Moxon SJ	anon	Pfam-B_7927 (release 9.0)	Family	This family consists of several eukaryotic Aph-1 proteins.Gamma-secretase catalyses the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease. It is thought that the presenilin heterodimer comprises the catalytic site and that a highly glycosylated form of nicastrin associates with it. Aph-1 and Pen-2, two membrane proteins genetically linked to gamma-secretase, associate directly with presenilin and nicastrin in the active protease complex. Co-expression of all four proteins leads to marked increases in presenilin heterodimers, full glycosylation of nicastrin, and enhanced gamma-secretase activity [1].	25.00	25.00	26.90	26.00	20.50	23.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.64	0.70	-5.12	14	233	2009-09-11 12:57:32	2003-05-29 11:43:55	7	3	130	0	130	218	1	207.00	40	91.12	CHANGED	TlssFFGCsFlAFGPulALFhhTIApDPlRVIlLlAuuFFWLVSLLlSSllWa.lhhslpsp.........lhFGlhhSVlhQEsFRahaa+LL+...............Ks-cGLpul......scpsphs...................................................................hsp+hlAYVu.GLGaGlhSGsFuhlNlLuDuhGPGTlGlcu...........sSphaFlsSAhhoLshlLLHTFWuVlaFsuC-pppahplshV.....VsoHLhlSsLTLLN..shapsoLlssYhlhllhulhAahssGGsltsh........p+hlssc	....................hhhhaGCshlAFGPshuLFhholAtcPl+.lIhLluuu...FFWLlSLLluSllWh.hhh.lpsp............lhh...uhhhSVhhQEhFRh.haa+ll+.............................Ksp......cGLt.sl.....stp.t.p..s..........................................................................shc.hAYVu.GLGFGlhS.....ulF.shl.NlL.....ucuhG..PGshGl..cu...............ss..aFLsSAhhohsllLLHsFWullhFsuh....-c...pp.....a.........htlhhV..........lhsHLhsShhThl.N......hhtssll..s.ahlhl.huhhAhhhsGushtsh..........................	0	44	63	93
+5934	PF06106	DUF950		Staphylococcus protein of unknown function (DUF950)	Moxon SJ	anon	Pfam-B_8992 (release 9.0)	Family	This family consists of several hypothetical proteins from different Staphylococcus species. The function of this family is unknown.	25.00	25.00	42.70	42.20	22.20	18.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.40	0.72	-3.99	3	163	2009-01-15 18:05:59	2003-05-29 11:48:11	6	1	123	1	4	53	0	108.80	74	96.00	CHANGED	MTLoQQLKpYITcLFQLs+sETWcCEulEElAEDILPE+YIcsSPLuHKILpTaTYYNDELHElSIYPFLhYhsKQLIAIGYLD.NFDMDFLYLsDT+psIIDERYLLpcGG	...KThTQELKQYIT+LFQLSNNEsWECEALEEAAENI.LPERFINcSPLsHLTLETYTYYNDELHELSIYPFLMYANNQLISlGYLD.HFDMDFLYLTDTpNsIIDERHLL+pGG....	0	0	0	4
+5935	PF06107	DUF951		Bacterial protein of unknown function (DUF951)	Moxon SJ, Eberhardt R	anon	Pfam-B_8994 (release 9.0)	Family	This family consists of several short hypothetical bacterial proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	25.20	38.50	21.90	24.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.75	0.72	-4.45	42	1332	2009-01-15 18:05:59	2003-05-29 11:51:50	6	4	1322	0	177	594	6	58.70	54	86.09	CHANGED	caplGDIVcMKKsHPCGo.......scWEllRhGADI+IK.ChsCu+hVMlsRtcFEK+lKKllp	.........YplsDlVEMKKsHsCGs.......N+WcIlRhGADI+IK.CpsCsH.VMhsRp-F-+KlKKll.........	0	75	122	152
+5936	PF06108	DUF952		Protein of unknown function (DUF952)	Moxon SJ	anon	Pfam-B_8995 (release 9.0)	Family	This family consists of several hypothetical bacterial and plant proteins of unknown function.	21.60	21.60	23.00	21.80	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.10	0.72	-4.12	102	618	2009-01-15 18:05:59	2003-05-29 11:55:22	7	18	597	3	250	535	577	93.40	34	69.98	CHANGED	IsstspWptuptsGpatsuslDht...-GFIHhSTspQ......lt.pTAs+aFuu...pssLlLL......slDsstLus..s..............L+WEs.................uc.uGtLFP........HLYG......sLslsAVhtsps	...................hstppWptApt..s.Gphtsusl-h.....-GFIH.h.S.o.s.p.Q..................................lt.tsA.s+aFsu.........ps-LlLL......tlDsstLss..s..................l+aEs............................uc.suthFP...............HLYG......sLslsAVlts..s........................	0	78	169	211
+5937	PF06109	HlyE		Haemolysin E (HlyE)	Moxon SJ	anon	Pfam-B_9001 (release 9.0)	Family	This family consists of several enterobacterial haemolysin (HlyE) proteins.Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri. HlyE is unrelated to the well characterised pore-forming E. coli hemolysins of the RTX family, haemolysin A (HlyA), and the enterohaemolysin encoded by the plasmid borne ehxA gene of E. coli 0157. However, it is evident that expression of HlyE in the absence of the RTX toxins is sufficient to give a hemolytic phenotype in E. coli. HlyE is a protein of 34 kDa that is expressed during anaerobic growth of E. coli. Anaerobic expression is controlled by the transcription factor, FNR, such that, upon ingestion and entry into the anaerobic mammalian intestine, HlyE is produced and may then contribute to the colonisation of the host [1].	25.00	25.00	26.40	26.20	22.20	21.70	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.91	0.70	-5.41	2	433	2009-01-15 18:05:59	2003-05-29 12:19:47	8	1	323	25	1	123	0	198.90	81	97.36	CHANGED	hsADpTVEsVKsAI-TADtALDLYNKhLDQVIPWpTFs-TlKELSRFKpEYSQuASsLVG-IKoLLMsSQD+YFEATQsVYEWCGVsTQLLsAYl.LFsEYsEKKASAQKsILIKVLDDGIhKLpcAQpSLhsSSQSFNsASGKLlALDSQLsNDFsEKSsYFQuQVDKIRKEAYAGAAAGVVutPFGLIISYSIAAGVVEGKLIPtLKpKLKSVpsFFpoLusTVKpANpDIDtAK.KLpsEIusIG-lKTETETTRFaVDYDDLMLp.Lp-uApKhI.oCNEYQKRHGKKs...l..	..hA-pTVEVVKsAIETADGALDLYNKYLDQVIPWpTFDETIKELSRFKQEYSQAASVLVGsIKsLLMDSQDKYFEATQTVYEWCGVsTQLLuAYIhLFDEYNEKKASAQKDILI+lLDDGlsKLNEAQKSLLsSSQSFNNASGKLLALDSQLTNDFSEKSSa.............................................hpN+LKusQsFFTTLSNTVKQANKDIDAAKLKLTTEIAAIGEIKTETETTRFYVDYDDLMLSLLKtAAKKMINTCNEYQpRHGKKTLhEVP...............	0	1	1	1
+5938	PF06110	DUF953		Eukaryotic protein of unknown function (DUF953)	Moxon SJ	anon	Pfam-B_9087 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	23.10	23.10	23.10	23.50	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.57	0.71	-4.66	6	278	2012-10-03 14:45:55	2003-05-29 12:22:26	6	11	184	2	189	321	7	113.10	28	71.30	CHANGED	sspGa-EFpcslcp..........tppsKslashFoGuKD.ssGcSWCPDCVpAEPVIc-uLKc.sst...-shFlhspVG-RshW+DPsssFRpssphKlTulPTLL+asss.p+..Ls-cpstpssLVEhhFsE	........................................................t......th.phhpt.............pp.s.p..s..l..alhFh.usc.D..ssGp.SWCPDCVpAEPs....lpp.s...h.....pp....hsp.......sshhlhsp.V..G.p+.s.h.W.+.c....s..s.NsFRp...phplpslPTLl+a...p..s.............s....t+.........L.tt.ph.t.phlt.....................................................	0	69	105	157
+5940	PF06112	Herpes_capsid		Gammaherpesvirus capsid protein	Moxon SJ	anon	Pfam-B_9200 (release 9.0)	Family	This family consists of several Gammaherpesvirus capsid proteins. The exact function of this family is unknown.	25.00	25.00	25.80	25.30	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.93	0.71	-4.16	8	23	2009-01-15 18:05:59	2003-05-29 12:31:16	6	1	19	0	1	19	0	156.30	31	92.09	CHANGED	MuptRl+cPhVQGRLEc-aPsc.LlschssLsQsNMoss-Yshs+RsYLVFLIApapYDpYlcpppGIpRK+H.......LpuL+upt...............pssstpsSuhSussuuuouls..................lSuoSso.uhoSuPuSLsuu....................suhosSsusussossssppKK	..Ms.hRl+cPhlQGRLEpDaPspPLlschpsLsQsNhosspYthspRsYLVFLhAQapY-tYlppptGlpR+cH.............lpshRspt.........................t..hsuuhSussuussusss.su..............lusouho..ohoSussSLtuu....................ootssususutsp....t..................................................................	0	0	1	1
+5941	PF06113	BRE		Brain and reproductive organ-expressed protein (BRE)	Moxon SJ	anon	Pfam-B_9280 (release 9.0)	Family	This family consists of several eukaryotic brain and reproductive organ-expressed (BRE) proteins. BRE is a putative stress-modulating gene, found able to down-regulate TNF-alpha-induced-NF-kappaB activation upon over expression. A total of six isoforms are produced by alternative splicing predominantly at either end of the gene.Compared to normal cells, immortalised human cell lines uniformly express higher levels of BRE. Peripheral blood monocytes respond to LPS by down-regulating the expression of all the BRE isoforms.It is thought that the function of BRE and its isoforms is to regulate peroxisomal activities [1].	20.70	20.70	24.70	24.50	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.17	0.70	-5.40	2	136	2009-01-15 18:05:59	2003-05-29 12:45:02	7	3	79	0	78	128	0	247.10	45	81.89	CHANGED	MSPEVALpRISP.LpPhlsSVVhNG+VGLDuTNCLRlTDLKoGCTSLTPGPsCDRFKLHIPYAGETLKWDIIFNApYPELPPDFIFGEDA-FLP-PStL.pLspWssuNsECLL.lVKELlQQYHpaQCpRLRESSRLhFEYpoLLE-PpYGcNMEIYAGKKNsWTGEFSARFLLKLPVDFSNIPsYLLK...............................................................................................Vlpaps-hhp+lslh................................F	...........................................................................................................................sDRFpLhIPY..sh-.tl+WDlIFsuphPphsPDFIF.G.......-.D......sc.FhP........-......s......s...t......l..t...s.....LspW...........ssssPcsLL..hllpELl...ppY+paQppRl.t..E..s..s..RL...hFEhpTLlpc.th.s...phcl.hs..shpps....ht.s.hl.lphs...lD..hs...p.l.P....h..h....c......p...sttsh..sh...l.s.sa.pssp.ss..ts.hP..cL.hL..SPp.l-.cuLhusssl+lPsas.s..G.hCLh-Yl.PplpphLpppV.p.slpshchRRcaItAhhshaGp.s.lEhDs..hhpKhohLh...tsFs..FLVH.ltlP.....h..FP+pQPslhhQSs.H................................................................	0	26	38	59
+5942	PF06114	DUF955		Domain of unknown function (DUF955)	Finn RD, Yeats C	anon	ADDA_4938	Family	Family of bacterial and viral proteins with undetermined function. A conserved H-E-X-X-H motif is suggestive of a catalytic active site and shows similarity to Pfam:PF01435.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.45	0.71	-4.39	77	5058	2012-10-03 04:41:15	2003-05-29 13:02:17	8	46	2529	3	1113	3932	890	119.90	16	37.22	CHANGED	scphGlplhhhs............hsttsttthth.t.......................sthlhlssp.hsttcptasluHELuHhhhpspt........................ht.tttpthEhpspth....AsthLlPpphhhtthtpthp.hp...........................lsptaplohphhthclp	..............................................................................h...........................................hh.hh.........................pthI.h.l.s....p....p....h....s....t..s.....p....p....t..a..sluHEL..u.Hhh.hp...ptt.....................................................t..t..t..p..p...p....t....h..E..h.....p....A....s.tF............AsthL..h..P..p........h..h....t....h....h.........t....h.h....th.................................................ltphh.tlohthh..t......................................................................	1	408	776	964
+5943	PF06115	DUF956		Domain of unknown function (DUF956)	Finn RD	anon	Pfam-B_9146 (release 9.0)	Family	Family of bacterial sequences with undetermined function.	25.00	25.00	49.50	49.30	24.70	18.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.50	0.71	-4.49	22	736	2009-01-15 18:05:59	2003-05-29 13:05:51	6	1	702	0	71	320	4	116.70	50	94.62	CHANGED	MsQSlNTKV-LsssGTuYhGhu.cYGKIhlGDcuFEF.YN-pNVccaIQIPWpplshVhAsVh..htGK.hIsR.FpIhTc+tGpFhFuSK-otclL+hlRcalss-+lV+u.olhpsI++tF+	..............MsQSlNppV-LsssuTSahG..lu..chGKhhlGDpuhEF.Ys-pNVccaIQIPWsclstlhAsVh......G+.hIsR.FplhTc.K.GpFhFASKDstplL+hhRcalssD+lV+..o.hhpsIppth.................	0	19	38	53
+5944	PF06116	RinB		Transcriptional activator RinB	Moxon SJ	anon	Pfam-B_9294 (release 9.0)	Family	This family consists of several Staphylococcus aureus bacteriophage RinB proteins and related sequences from their host. The int gene of staphylococcal bacteriophage phi 11 is the only viral gene responsible for the integrative recombination of phi 11. rinA and rinB, are both required to activate expression of the int gene [1].	21.80	21.80	26.00	25.70	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.52	0.72	-4.35	6	399	2009-01-15 18:05:59	2003-05-29 13:10:11	7	2	218	0	7	163	0	48.60	80	91.72	CHANGED	MIK+ILKIhFhluMYEluKYlTcELhlhLTuNDDVE.sPpDFs..sDHhHLN..th.	...........MIKQILRLLFLLAMYELGKYVTEQVYIMMTANDDVE.APSDa.............lhtt.	0	3	3	7
+5945	PF06117	DUF957		Enterobacterial protein of unknown function (DUF957)	Moxon SJ	anon	Pfam-B_9300 (release 9.0)	Family	This family consists of several hypothetical proteins from Escherichia coli, Salmonella typhi, Shigella flexneri and Proteus vulgaris. The function of this family is unknown.	25.00	25.00	27.50	27.00	24.30	23.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.07	0.72	-4.43	5	548	2009-09-11 11:38:57	2003-05-29 13:13:47	6	2	255	0	4	177	0	63.60	84	81.52	CHANGED	MphLTshoALDVLIuWLpDNIDpGS-IIFDNDEDNTDSAuLLPslE+ARpslRcLcuLu..pl+usR	........MKSLTTETALDILIAWLQDNIDCESGIIFDNDEDKTDSAALLPCIEQAREDlRTLRpLQ..LLcQNR.....................	0	0	0	2
+5947	PF06119	NIDO	DUF958; 	Nidogen-like	Yeats C, Myerscough N	anon	Pfam-B_1159 (release 8.0)	Family	This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function [1].	25.00	25.00	25.00	25.60	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.30	0.72	-3.28	27	552	2009-01-15 18:05:59	2003-05-29 13:30:38	9	172	103	0	395	611	5	85.80	32	7.07	CHANGED	sNTFQslLs...oDuspoasl.FhYsp..lpWsssp.....t...t...th.ApsGFsuG-s........sphasl.Pusc..tslhsLhps.oNsGhsGhWhF+l.sst	...............NTFQsVLs......oc.us.....t....oasl.F.Ysp..l.....pWsssp.........t..........t.h.s......A....psG.Fss.Gsu..................sphasl.PuSpp......psl......h....s.....ltps....oN...s...u..hs.GhWhF+lst.t...............................................	0	136	197	302
+5948	PF06120	Phage_HK97_TLTM		Tail length tape measure protein	Moxon SJ	anon	Pfam-B_10088 (release 9.0)	Family	This family consists of the tail length tape measure protein from bacteriophage HK97 and related sequences from Escherichia coli O157:H7.	23.80	23.80	23.80	28.00	23.50	23.70	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.95	0.70	-5.08	2	304	2009-01-15 18:05:59	2003-05-29 14:09:55	6	6	199	0	11	409	2	245.40	55	27.07	CHANGED	QpsLNSsTuVhshlhsGAhG...LlGGlPGllMLGAGAWYshYQpQEQARpSAhpYAsTIEplRsph+pMS.sphosN.upsp.uLctQNphIppQcpKltplpstl..YpthLAssuso.ssahhN......-AspchAs.sstLAVEptRLpQM.sKppphQpllpslpcptl....ppssE.stshpSLh.M......asRL....Npl..uRQuhAs.P.+.....lPt...sppQppAlEKupRpLELStLpG.sKthtphtasAsDLsLsss......RpthlshtlEohRp.pA..Npsp+KGs	...............................QptLNssTuV...GoRLhoGALG......LVGGlPGLl....ML....G..A.u.AW.YTL..Y...QNQEQARESARQYAhTIDEIspKssuMSLPEhoDNEu+TRtALsEQNRLI-EQtS+l+uLpcK...It..s.Yp...h.sLss.su.hss.s.Ghh..l...s...s...tsVT-sLApATcp.LA...VEQsRL....sQMQp..KupS.IQ-lL..A.GLE-RRV.A....LI...RQQA.AEQN...+..sYQShLl.M..N.GQaT.E.....FNRLLGL.GNELLQQ..RQ.GLVNVPLR..................................LPQAT....LD..DKQQoALspoERE.LAL.SRLKGE.tKERsRLGYAADDLGF.VG.-....sYQpARQpYIsNuL-AWRNNps..NKPKu..................................................................................	0	0	1	9
+5949	PF06121	DUF959		Domain of Unknown Function (DUF959) 	Yeats C	anon	Pfam-B_25471 (release 8.0)	Domain	This N-terminal domain is not expressed in the 'Short' isoform of Collagen A [1].	25.00	25.00	27.00	27.00	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.57	0.71	-4.67	3	37	2009-01-15 18:05:59	2003-05-29 14:10:13	9	19	24	0	16	34	0	173.50	48	14.16	CHANGED	LLpCpLsuAcA-ssSLSs.p..sWLWhPpT-sS.sAoolucPQuSoPVQSTE....sTTTHVVPRsGpTEpuTTPASSE.PsEl.....lE-GcQpss.GssssTPTVs.shhssAuSPDh..........sEENIAGVGAEILNVAcGIRSFVQLW.EDoVsscS...ApT.VPDTsl.PhVLAoP..lSSsPQsssTTLW.SSuIPSSPuApTTEAGT...LuuPTpLP	.........LL.CsLsuApAchhsLs......WLW.sppsss.htsslscPpss.sVQsTt....ssTTHVsPps..G.TE.tTss.uSsc.P.E.......Etupt.........oPo.......sAtSPDh..........pEENIAGVGAKILNVAQGIRSFVQLW...cDoss.scS...ApT.sssoss.PhsLPsP......SSsPQpssTTLh.SpshsSSPsspTTEAGT...LssPT..................................	0	1	2	7
+5950	PF06122	TraH		Conjugative relaxosome accessory transposon protein	Moxon SJ, Coggill P	anon	Pfam-B_10166 (release 9.0)	Family	The TraH protein is thought to be a relaxosome accessory component, also necessary for transfer but not for H-pilus synthesis within the conjugative transposon [2] [3].	25.00	25.00	28.50	28.40	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.28	0.70	-5.64	41	471	2009-01-15 18:05:59	2003-05-29 14:14:35	6	3	341	0	63	366	37	338.70	34	76.51	CHANGED	hsshF.sshsh.uNsTsPuuapuQstGaaoGGulhsRssh..cshpLhslshPshpAGCGGIDhFhGuFSFINu-plVphh+sIsuNAs....uaAFpLALpslsPplspshppLpphsptlNphshsSCphApulVsshh..spt..sss.ppphsps...hu..spsuhhsDahsu.pptstsssppss...............hstsssssttpp.hhhstNlsWpulp+sshh...........tsspphtEhlMSlsGTlIh.......sssussh.hst.hssssshlss......LlsGss...t.......hclapCs...ss.....spCl.......s.pshslstt.............pulpsplpphl..............puIhsKlts.c.....ssLos....scpsFl.ss..oslPlhchlphtssh.thshusp.hpphu-hlAh-lhhphLpph	....................MsphF.sph...tuNsTpPusapuQstGh.hsGGSlhsRspl..ps..hpLlShshPshsAG...CGG.IDhahGSFSFINu-Qlhphl+pIhuNAs....GYhFpLALpshsPchpssh-hLQchspplNphshsSCphAQulVsshh......spt....pss.pppssps...lu.......spsshhuD..asuu.pptss.suuppss......................hspAssp..pccthhhshNlhWpALp+sphh................................tuspcLtEhlMoloGollh.................sssuphs.h.ss.hs.ss..ps...hlps....................hhc.GGs.............................sclYpCs..ss..........spCL.......sssssolspt......................................puLpsplpphL.........................suI.sKhss..c.....ssL.ss....pEKuFl.ss..oslP....lhphl..hss.....ususshh.phs-hIuh-hhhpalp-...............................................................................................	0	18	33	50
+5951	PF06123	CreD		Inner membrane protein CreD	Moxon SJ	anon	Pfam-B_10187 (release 9.0)	Family	This family consists of several bacterial CreD or Cet inner membrane proteins. Dominant mutations of the cet gene of Escherichia coli result in tolerance to colicin E2 and increased amounts of an inner membrane protein with an Mr of 42,000. The cet gene is shown to be in the same operon as the phoM gene, which is required in a phoR background for expression of the structural gene for alkaline phosphatase, phoA. Although the Cet protein is not required for phoA expression, it has been suggested that the Cet protein has an enhancing effect on the transcription of phoA [1].	19.70	19.70	20.00	19.80	18.10	19.40	hmmbuild  -o /dev/null HMM SEED	430	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.13	0.70	-5.94	48	880	2009-01-15 18:05:59	2003-05-29 14:19:36	7	2	798	0	101	509	60	380.70	47	94.10	CHANGED	pslhhKhhhluhLhLLLlIPLhhlpslIpERpphpppslscIupShuupQplsGPllslPap.cphpppp....stpthpphpp.....................hhhlLP-pLslsuphpsc.RpRGIYps.VYpupsplpupFshs...t.p.phhstpplh.........hspshLsluloDh+GIpsssplplsG.p.slsh.........pPGs.............thsthsp..Gl+sslsthshpps.........tlsashsLpLpGoppLullPlGcsoplsLpSsWPHPSFsGsaLP..spRplossGFpApWpsothupshsphh..........ttss.sshsttu.............huVshlpPV-tYpps-RAsKYulLFIsLTFhuFFlhEllpphtlHPlQYlLVGLALslFYLLLLSlSEHlGFshAYlluususlhLluhYlsslL+uh+puhsauuhLssLYulLYslLptEDaALLhGSllLFhlLuslMhlTR+lDWYs	...............................................................................s.sLhaKhssLhshhlLLLIPlhhlcplIsERucYRscV.ssIppSoSGsQ+llGPllslPhoEhhpsp-......ppKpsppp+sh....................hhahLPEsLhVcGs.ss.Et.R+hGIYpupVapu-hsl+AcFcls.........ph..p-l.s..t..sslt.........hucPalVluluDsRGIsslps..plsG......p.sL.sl............................EPGs.......................................ultpsspGl......HhP..Lsps.shtpp.............................sLplsh.sLsLsGTuslSlVPsG+sochsLsSNWPHPSFhGsFLP...scRclo..ts....GFpApWpoShh...AsN.hsppa......................sss..pph.sh...shsu......................FoVulhsPsDpYQlo-RAsKYAILhIsLTFhuFFlFEsLosp...RlHPhQYLLVGLuLVh..FYLLLLuLSEHlGFshAallASLhsslh.ulYLpuVL+uh+puhlF...shuLlhL.GlhauL.LpStDsALLlGoslLhlsLuuhMalTRplDWYt..........................................	0	29	52	73
+5952	PF06124	DUF960		Staphylococcal protein of unknown function (DUF960)	Moxon SJ	anon	Pfam-B_10198 (release 9.0)	Family	This family consists of several hypothetical proteins from several species of Staphylococcus. The function of this family is unknown.	25.00	25.00	25.80	25.70	24.10	23.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.94	0.72	-3.74	11	633	2009-09-11 15:24:04	2003-05-29 14:22:46	6	1	565	4	34	211	0	93.80	41	90.95	CHANGED	sRYAShGlVoSLPs-lIDshWhII....DppLKsVhsL-sllpFpLlNspGplol+FSQcpssshlshDhshhasPha..Pp+VallDpss+ET....IlLPcE	.......tRaAShGlsoSLPs-lIDohWhII....Dc.hLKsVhcL-plLpFpL.h..s.s.pG.....p....l...o.h+FSppp.sst..l-....aDasp..a..cspa..Pt+VhVlDpDspET......ILLPEE........	0	8	15	25
+5953	PF06125	DUF961		Bacterial protein of unknown function (DUF961)	Moxon SJ	anon	Pfam-B_10221 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	26.20	26.00	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.18	0.72	-3.84	12	903	2009-01-15 18:05:59	2003-05-29 14:24:23	6	1	354	1	46	274	8	100.40	42	88.16	CHANGED	.hchlVs-hpcTFGsLcFuu.sc.lhtps.sGphs....hpRoYsLhSslQ.uc.I.VolPApAG.KcFs.ptcVcLlNPhlsshuhthhp.G..hssahlcADDlVh	..................hphlV.Dh-pTFGpLcFuu.cc.Vh.ps........tsGssos...hpRoYsLhSssQ.uc.I.VslPAp..ss.K..cF....sYptcVcLlNPhhs.shuhthhp.G.....ssahl+ADDlVh.....................................	0	22	33	35
+5954	PF06126	Herpes_LAMP2		Herpesvirus Latent membrane protein 2	Finn RD	anon	Pfam-B_9147 (release 9.0)	Family	Family of Kaposi's sarcoma-associated herpesvirus (HHV8) latent membrane protein.	20.80	20.80	21.20	139.90	19.90	20.70	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.76	0.70	-6.09	2	12	2009-01-15 18:05:59	2003-05-29 14:30:16	6	1	3	0	0	12	0	457.10	70	99.80	CHANGED	ph+hahWshWhhALlsChhClolh.ClhT....NoI.hhusl.Vhh.LFsohhNhYsQ...Spp.+a.uS..lG...IluCIsht.WshoTpsolohsClhhhulLSllTAhLuLhtphpssKhpl-pGlLChshhhVLIhsMhlph.NsWpps.hFhPl.hhL.l.FlahFATspssslKLsusV.hICuGllhuhPs.hChoHoChushhuhslSsIalGhTGlhhTh++pWhssp+GlhoFLLLQGGVLsT.ThThtlLhIpppp.sN.cGp.hLLhsChhhLaChasWQSFpKASLssGhLaLhhAWopsGsCVpLVhLhssGhTpGlhohlICl.slhSThQulLVhYLY+Ep+lVuhNsh.ppRh.IYT.cps.Htps.......NHLuppl...PPLPsh.h..sRl.SpsTD......RspsopshsplEhQplpp-..pshsYASILssss..spcsSsp.sQSGhS..pVsssushplD...sshQPsD-lYEEVLFPps	....hhhFFWNLWLWALLVCFWCITLV.CVTT....NSIDTMASLLVMCILFVSAINKYTQAISSNNPKWPSSWHLG...IIACIVLKLWNLSTTNSVTYACLITTAILSLVTAFLoLIKHCTACKLQLEHGILhTSTFAVLhTNMLVHMSNTWQSSWIFFPISFTLSLPFLYAFATVKTGNIKLVSSVSFICAGLVMGYPVSCCKTHTCTATAAGLSLSSIYLGFTGIISTLHKSWAPPKRGILTFLLLQGGVLTTQTLTTELLAITSTT.GNIKGHEILLLVCLIFLWCLYVWQSFNKASLVTGhLHLIAAWSHTGGCVQLVMLLPSGLTRGILTMIICISTLFSTLQGLLVFYLYKEKKVVAVNSYRQRRRRIYTRDQNLHHND.......NHLGNNVISPPPLPPFFRQPVRLPSHVTD......RGRGSQPLNEVELQEVNRDPPNVFGYASILVSGAEESREPSPQPDQSGMSILRVDGGSAFRIDTAQAATQPTDDLYEEVLFPRN.............	0	0	0	0
+5955	PF06127	DUF962		Protein of unknown function (DUF962)	Moxon SJ	anon	Pfam-B_10320 (release 9.0)	Family	This family consists of several eukaryotic and prokaryotic proteins of unknown function. The yeast protein Swiss:P25338 has been found to be non-essential for cell growth.	24.00	24.00	24.00	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.21	0.72	-4.09	66	1112	2009-01-15 18:05:59	2003-05-29 14:30:38	6	4	665	0	460	999	358	125.90	25	82.98	CHANGED	apoFt-FaPFYLspHpssssRtLHalGoslllhhlhhs.lhssp......................................................................h...hhllsh.lsGYuFAWlGHFhaEKN+PATFcaPLaSlhuDahMahphlsG+l	......................................................................................................................................................tshtcahshY....hs.Hps.hNh.tlHhlulshll...h...slhhh....lsph.s................................................................................................................................................h.hhsl.u..lhl...lGa..s...h.Qa..l.....GHh.aEtp+PAh.hcs.l...uLhhs.hhlht.lhh..h..............................................	0	141	254	370
+5956	PF06128	Shigella_OspC		Shigella flexneri OspC protein	Moxon SJ	anon	Pfam-B_10333 (release 9.0)	Family	This family consists of the Shigella flexneri specific protein OspC. The function of this family is unknown but it is thought that Osp proteins may be involved in post invasion events related to virulence. Since bacterial pathogens adapt to multiple environments during the course of infecting a host, it has been proposed that Shigella evolved a mechanism to take advantage of a unique intracellular cue, which is mediated through MxiE, to express proteins when the organism reaches the eukaryotic cytosol [1]. 	23.60	23.60	23.60	35.20	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.81	0.70	-4.91	3	72	2009-01-15 18:05:59	2003-05-29 14:34:55	6	1	24	0	2	67	1	245.20	77	66.94	CHANGED	VEISNH.QcK+PLN+KHHTVDFGANAYIIDHDSP...YGYMTLTDHFDNAIPPVFYHEHQS.FLDsFsEVscEVSRYVHGuKG+pDVPIFNTKDMKLGlGLHLIDFIRKSKDQuFKEFCYsKNlsP.VuLDRIINFVFQsEYHIPRMlST-NFKKlKLR-ISLEEAVcASNYEEINspVTsKKhAlQALaaSIsNpK-DVALYLLSNFcFT+QDVAShc+.......sLY.DlEYLLScHGASsKVLEYFIN+GLVDVNsKFcKsNSGDTMLDNAlKYcNuEMIchLLKaGAh.D++a	.......VEISsH.QcphPLNppHHTVDFGANAYIIDHDSP...YGYMTLTDHFDN......AIPPVFYHEHQS.FLDpFpEVs-EVSRYVHGspGppDVPIFNTKDM+LGlGLaLIDFIRKScDQuF+EFCYsKNlsP.VsLDRIINFVFQ.EYHIPRMlST-NFKKl+lR-ISLE-AlpASNYEEINppVTsKKhAhQALhhSl..sNtKtDhALYlLSpFphT+QDVhphc+.......pLY.DlEYLLStcsushKVLEYFINpGLVDVNp+FpKsNSGDsMLDNAhK.csucMIchLLK.GAh.sp+a.............................................	0	2	2	2
+5957	PF06129	Chordopox_G3		Chordopoxvirus G3 protein	Moxon SJ	anon	Pfam-B_10417 (release 9.0)	Family	This family consists of several Chordopoxvirus specific G3 proteins. The function of this family is unknown.	22.30	22.30	22.40	22.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.26	0.72	-3.91	12	50	2009-01-15 18:05:59	2003-05-29 14:37:30	7	1	42	0	0	33	2	107.80	52	98.97	CHANGED	usLl.lhFFllFLllsYahsahPTNKhpluVpphs.-ttlhKptssshss.hhsThlFscs-phlssplpshYcupputVslhpsscKhsFpLshccDVRsLLPILLLSK	.u.sLLYLllFllFlsluYYFoYYPTNKLQhAVhEpscENAII+QRN--l..Po.oL-TsIFTcssolsSupIpLYYNSshG+llhuhN.uKK+TFNLhcDsDIRTLLPILLLSK..	0	0	0	0
+5958	PF06130	PduL		Propanediol utilisation protein PduL	Moxon SJ, Bateman A, Finn RD	anon	Pfam-B_10447 (release 9.0)	Domain	This family consists of several bacterial propanediol utilisation protein (PduL) sequences. The exact role of this protein in propanediol utilisation is unknown. Sequences containing this domain usually have two tandem copies (Bateman A, pers. obs.).	25.00	25.00	26.90	30.00	19.20	18.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.26	0.72	-4.16	125	1579	2009-01-15 18:05:59	2003-05-29 14:40:30	7	10	646	\N	291	1010	41	75.90	35	69.09	CHANGED	phsVhlusRHlHhopcDscthhs.............psGphsshcs...sGs+.shhcsVhlhuss+hpsphclsts-ApuhGlp	.........s..slhVupRHIHho.pDsctLhs.............psGphsshch...sGs+.shhcsVhlhss.s+htsphcIsts-ApshGl.....	0	156	224	254
+5959	PF06131	DUF963		Schizosaccharomyces pombe repeat of unknown function (DUF963)	Moxon SJ	anon	Pfam-B_10581 (release 9.0)	Repeat	This family consists of a series of repeated sequences from one hypothetical protein (Swiss:Q96WV6) found in Schizosaccharomyces pombe. The function of this family is unknown.	21.00	21.00	21.30	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.47	0.72	-4.68	8	150	2009-01-15 18:05:59	2003-05-29 14:45:17	6	5	8	0	146	151	2	35.90	79	70.47	CHANGED	ITSSoslNSSTPITSSTslNSSTPIsSSSlLNoSTP	.....ITSSoVLNSSTPITSSTVlNoSTPITSSoVLNSSTP.......	0	144	144	146
+5961	PF06133	DUF964		Protein of unknown function (DUF964)	Moxon SJ	anon	Pfam-B_10600 (release 9.0)	Family	This family consists of several relatively short bacterial and archaeal hypothetical sequences. The function of this family is unknown.	22.10	22.10	22.40	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.31	0.72	-4.03	233	2444	2009-01-15 18:05:59	2003-05-29 14:52:23	6	3	1220	12	316	1032	15	107.70	22	85.69	CHANGED	slhDpAppLsctlppo-EapshcpucptlpsspcupplhpcFpphQpph.pphpphGc..s..ccsppchpphtpplptpshlppahpuppplsplls-lsphIspsls-h	.........sIhDpAppLsctlpps-phpshcpucptl.psspcsp..plhpcapphQpph..pphp.phGc.hs.....ccstpchpphtpplptpsllppahpsppphspllp-lsphItpsls-.................	0	99	196	262
+5962	PF06134	RhaA		L-rhamnose isomerase (RhaA)	Moxon SJ	anon	Pfam-B_10641 (release 9.0)	Family	This family consists of several bacterial L-rhamnose isomerase proteins (EC:5.3.1.14).	19.60	19.60	19.60	19.80	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.41	0.70	-5.57	5	861	2012-10-03 05:58:16	2003-05-29 14:57:12	6	2	844	20	102	524	40	402.70	65	97.99	CHANGED	MslKpsYEpAKpcYppWGIDVEEAL+pLKQlPISIHCWQGDDVsGFElscGELSGGIDVTGNYPGKApTPEELRpDLEKALSLIPGKHRVNLHAIYAETDtEsVERDEIEP+HFENWV+WAKcpGLGLDFNPTLFSHPKAcDGLTLAHPDc-IR-FWI-HCIASRKIuEYFGKELGTPuLTNIWIPDGYKDIPSDRLTPRKRLcESLDcIFuEEIDEpYNlDAVESKLFGIGSESYVVGSHEFYMGYALoNcKLCLLDTGHFHPTEsVSNKISSMLLYoDcLALHVSRPVRWDSDHVVlLDDELREIALEIVRNDALD+VpIGLDFFDASINRIAAWTIGTRNMIKALLaALLpPsucLKcLQEEGDYTcRLAlhEEhKTYPFGAIW-hYCEpMsVPVGE-WLcEVKtYEKEVLLKR	..............................................................................................plEQAaElAKpRaAAlGlDVEcAL+pL-+lPVSMHCWQGDDVsGFEN.P-.GuL.T.G..GIQATGNYPGKARNusELRuDLEpAh.............p.LIPGsKRL.NLHAIYL...E.oD...p.s..VsRDpIcPEHFcsWVEWAKtNpL.GL...D...F...NPoCFSHPh.Su.D.GF...TL...SHsDcpIRQFWI-HCKASRRlSAYFGEpLGTPSVMNIWIPDGMKDI..T.VDRLA.P.R.Q.RL.ls.ALDEVlSE.K.lcPAHpIDAVESKLFGIG...AES..YTV..G..S..NEFYM..GY....A....sS....R......p.s...s.L..CLDAGHFHPTEVISDKISAshLYVPpL.L.LHVSRPVRW.DSD..HV..V..L...LDD...ETQAIAsEIV...R.c.....c.L..h...D.........R...V...H...IG..L..D.FF.DASIN...RIAAWVIGTRNMpKALLRALLEPTspLRcLEssGDY.T.u.RL.AL.LEEpKSLPWpAVW-hYCQRpcsPsGu-WL-sVRsYEKclLSpR.................................................................................................	1	34	68	84
+5963	PF06135	DUF965		Bacterial protein of unknown function (DUF965)	Moxon SJ	anon	Pfam-B_10661 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins. The function of the family is unknown.	25.00	25.00	27.30	39.10	24.40	17.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.63	0.72	-3.93	34	1369	2009-01-15 18:05:59	2003-05-29 15:32:34	7	1	1357	0	173	496	5	78.80	59	90.15	CHANGED	hDcTMpFchscpc.pppl+-lLpsVYpALcEKGYNPINQIVGYLLSGDPAYIspap-ARsLIR+lERDEIlEELV+sYLp	................DcTh+Fc.h.c-sp..cp.clp..-sLpsVYpuLpEK.GYNPINQIVGYLLSGDPAYIPRaNsARN.IR+hERDEIlEELV+hYLc..	0	76	119	147
+5964	PF06136	DUF966		Domain of unknown function (DUF966)	Finn RD	anon	Pfam-B_8637 (release 9.0)	Family	Family of plant proteins with unknown function.	22.40	22.40	22.70	42.50	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.35	0.70	-5.02	15	135	2009-01-15 18:05:59	2003-05-29 15:43:41	8	4	19	0	91	127	0	321.00	29	72.73	CHANGED	VsVVYYLoR.NGp..LEHPHFlEVhluSpsG.......LYLR........DVIsRLssLRG+GMAuhYSWSsKRSYK..NGFVWaDLu-.DDlIhPs...sspEYVLKGS...............Ellcss.p....................s..sp.thps......p...spp.p....ssshsshs++pstsh...........................................uShshsEY+lhKsp-.tt.......tt..huuDASTQT--shptpp.h...................................sspscsspls+p-h.SPssos......tuss-oLEsLh+A-uphhpu.phhppppht..................+h+AoulLMQLISCGuhSsKc.........tpuhthspph+sphspu.hsp...tts................ph....tphphE-KEYFSGSLlE..TKppp........thsuLKRSSSYNs-Rusph	....................VtVVYYLsR.sup..LE.HPHahEVshsu..p.s...........LhLR...................................DVhpRLssLRG+GMsshY......SWSsK...RsYK..NGaVWpDLs-.-DlIhPs....pu.s.EYVLKGS...............Elhptsss..................................................................p.t...pp........t.......t.t........tss.ss...p.t.pptts..............................................................................................................................................................ss.s...tchps..cspt..................hstssuTpTccptpt.t.t.........................................................ttptptsplspcph...ssssss.......tsps....pshc.slhpscs...p.hh.ts.p..p..p...t.........t......................+h+sus.lLh.QLIo.CG.uhuspp..........tshh.h....hp.ph..............................................h....ht.th.cp-hFSGullp.pt..t...........s.L+pSsuhs..h.................................................................................................................................................................................................................................................................................................................	0	17	54	74
+5966	PF06138	Chordopox_E11		Chordopoxvirus E11 protein	Moxon SJ	anon	Pfam-B_10685 (release 9.0)	Family	This family consists of several Chordopoxvirus E11 proteins. The E11 gene of vaccinia virus encodes a 15-kDa polypeptide. Mutations in the E11 gene makes the virus temperature-sensitive due to either the fact that virus infectivity requires a threshold level of active E11 protein or that E11 function is conditionally essential [1]. 	21.00	21.00	22.80	51.10	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.54	0.71	-4.05	8	48	2009-01-15 18:05:59	2003-05-29 16:57:42	7	1	34	0	0	33	0	127.00	59	97.10	CHANGED	MELVNIFLESDsGRVKLth-.ssptCtpp.tsphh+AlchFlslL+KYIcV-cSTFYLVIKDpDIFYFKhDKGplo.l-NEFaTFscsLhFlc.sa..scITGIpFllTDTMslpIhP+sshtVlupSsNp+aY	MELVNIFLETDuGRVKhsIcNs-chCsop.......hIs+FlElLucYI+l-pSpFYLVVKD.KDIFYFKCDRGSISlVsNEFYV.FDEsLLFVc.Da..opVTGVEFIVT-TMPs+IlPKssaAVISsssN+KFY......	1	0	0	0
+5967	PF06139	BphX		BphX-like	Finn RD	anon	Pfam-B_8664 (release 9.0)	Family	Family of bacterial proteins located in the phenyl dioxygenase  (bph) operon. The function of this family is unknown. 	24.70	24.70	24.90	177.70	23.50	24.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.80	0.71	-4.58	7	27	2009-01-15 18:05:59	2003-05-29 16:59:10	7	2	26	0	4	18	1	135.70	63	97.89	CHANGED	MK..........psRsFLlAlGlFYLhNLlGTLPFtshuLhshMYPGVthpsutPhFpLLpDAWhVVGLQLuAIGlVALWGARDPhRYh.AllPVVIsTElVsGlWDhYSlsWu+.AlhFuLsTLllHslWIsWuLhshRuspppt.......t	....MKpuRlFLIAlGlFYlhNLlGTLPFuohGLFuhMYPGV-LcsGsPlFsLLpDAWAVVGLQLGAIGsVALWGARDPhRYh.AVlPVVIATEVVDGLWDFYSIlWSHEAhWFGLsTLlIHslWIsWuLaAWRAhtpp.sh.	0	1	3	4
+5968	PF06140	Ifi-6-16		Interferon-induced 6-16 family 	Finn RD	anon	Pfam-B_9299 (release 9.0)	Family	\N	25.20	25.20	25.20	25.30	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-4.20	27	261	2009-01-15 18:05:59	2003-05-29 17:08:26	8	6	81	1	139	237	0	77.60	48	56.27	CHANGED	AslG.Gsh...AVsAsPllLuAlGFTuuGIAAuSlAApMMSuAAlANGGGVAAGSlVAsLQSsGAAG..LSssusslluusGuslGuhl	.....................hhG.ush...sV...sus....Ph....s....Lu.....AlGFTuuGIAAuSlAApMMSsuAlA.NGGGVuAGSLVAsLQSlGAsG.....luh.s.u...p.h.hlussGushsh..h......................	0	52	68	93
+5969	PF06141	Phage_tail_U		Phage minor tail protein U	Finn RD	anon	Pfam-B_9209 (release 9.0)	Family	Tail fibre component U of bacteriophage.	25.00	25.00	26.90	26.50	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.62	0.71	-4.13	8	798	2009-01-15 18:05:59	2003-05-29 17:25:50	6	2	357	23	15	274	3	127.30	64	99.43	CHANGED	MpKHopIRpAVLsALcpphusssoaFDG+PuFl-.Ep-LPAVAVaLTDApYTGphlDpDsWQAsLHltVFL+AQAPDSELDhWMEp+IaPALp-VsGLssLIsTMsspGYDYQRDDEMAhWuuADLoYpITYsh	........M.KHT-IRAAVL-ALc.cp.....cs.u......ATh.FDGRPulh.........D....EpDhP.AVAVYLT.-ApY.TGEplDs.DTWpApLHIEVFL.A.Qs.PDSELDtW.......ME..S+I...YPAhs...sIPALS..sL..IsoMls..pGY-YRRDD-huhWuSAD.LTYsITYEM............	0	0	3	8
+5971	PF06143	Baculo_11_kDa		Baculovirus 11 kDa family	Finn RD	anon	Pfam-B_9424 (release 9.0)	Family	Family of uncharacterised Baculovirus proteins that are all about 11 kDa in size.	22.20	22.20	22.20	22.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.88	0.72	-4.62	16	47	2009-01-15 18:05:59	2003-05-29 17:40:57	6	1	45	0	0	42	0	85.70	38	88.72	CHANGED	Mppssuplsst.s...............sSll-tDQLsQlVoRNRoFl+DFlLVICuhlVFVhIlLFllLlhsI.psh-h.ptp+.phppshLuNhDh+	...............Mp.pstthhs...s...............sSshstDQLpQlV..sRN+oFl+-FlL.VlCuh.llFVhlllFlhLl..hsI.pshEh.....psp+.phppshLtNhDhR......................	0	0	0	0
+5972	PF06144	DNA_pol3_delta		DNA polymerase III, delta subunit	Finn RD	anon	Pfam-B_9452 (release 9.0)	Family	DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction [1]. The delta subunit is also known as HolA.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.62	0.71	-4.75	24	4182	2012-10-05 12:31:09	2003-05-29 17:51:43	8	10	4065	11	910	3675	1752	168.00	20	49.90	CHANGED	YllhGp-.hLlpcsppplhptshppshp-hshhph-hsps.hp..lhpphpohshFus++llhlp.s.........psthstp.hppLpphlpphsscslLllhus..KLscchc...hhKhLpp...puphlcsps.....ctpplhpalpphspphslplspcuhphLhthhpsshttltpplp+Ltl	........................................................................llhGs-.hL..hpctt.s...t...lh.pt.....h......h......t....p.....s..h......p............-....h.p.....h..h...p..h...-......h......p...p...s.........h..p.............l....h.....s.......p.s.ps.h...s.h...F....u...s..c......+...llllc.s..........................ppt.spp...t...h....c..t....L.h.p....h..h....p....p.........s.....s....s...sl...L...ll..ht...s....+....lsc.ppc......................hhctLp..p.........pu.h..h..l.p...s......t.p...........ct.p.pl....pa.lp......pc.h....p.p.t....s...l.....p.....l.....s.....s.....s.....A.......h.p.......hL....h......p.......t....h.......s.......s.......s....lhtltpplp+Lt...........................................................................................	1	308	602	775
+5973	PF06145	Corona_NS1		Coronavirus nonstructural protein NS1	Finn RD	anon	Pfam-B_9242 (release 9.0)	Family	Bovine coronavirus NS1 encodes a 4.9 kDa protein [1].	25.00	25.00	29.10	29.00	18.20	16.90	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.90	0.72	-7.33	0.72	-4.64	2	37	2009-09-11 06:11:25	2003-05-29 17:53:54	6	2	34	0	0	20	0	28.80	90	77.53	CHANGED	MphKFVFDLLsPDDILHP.NHVp.IIRPI	MpTKFVFDLLAPDDILHPSNHVNLI.IRPI..	0	0	0	0
+5974	PF06146	PsiE		Phosphate-starvation-inducible E	Finn RD	anon	Pfam-B_8639 (release 9.0)	Family	Phosphate-starvation-inducible E (PsiE) expression is under direct positive and negative control by PhoB and cAMP-CRP, respectively [1].  The function of PsiE remains to be determined.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.88	0.72	-3.74	96	1842	2009-01-15 18:05:59	2003-05-29 17:55:37	7	5	1500	0	409	1034	1208	68.20	32	49.00	CHANGED	lsslLhlllhlElhphlhtYhcpp.cl..tlphllhhAlhAlsRtlIl.htsthps..h.....htlussllhLuh	..............thlhhFlhFEhluh.l.l.p.Y.hpss...Hh..PlRahlhIuIoAllRhlI.ls.cc.s.shss.................lhhuuulLlLs.................................	0	88	221	323
+5975	PF06147	DUF968		Protein of unknown function (DUF968)	Finn RD	anon	Pfam-B_9463 (release 9.0)	Family	Family of uncharacterised prophage proteins that  are also found in bacteria and eukaryotes.	30.10	30.10	30.20	30.20	29.80	30.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.32	0.71	-4.41	23	1469	2009-09-11 20:49:19	2003-05-29 18:00:05	6	7	701	0	60	1205	78	190.80	45	67.20	CHANGED	sspcLp.shsppplssh...slptplphsDs+plohtphph.aAltNDl......tphh...PpsshR+hhph.hphhpuh.....-sclshup.s.so...pphtpclh..................chllshsh-s-sPhsahppsthpp...cpalha.ltspsCslCG....+tssDhHHl....IG+Gps+hthctaDhallsLCRcHHpElHp.sspsF-cKYthph..lhlpcpls+tLsls	...............................................................................s.s-pLp.phsppNhssWhlsllccshshspp+clolsELsW.WA.lpNpl.................sDsL..............PEushR+uL....t...l.t..c.tlpohh....RESDIlPu.c.psA.T...sIl.pp+sK.....................cpVlultVDPESPt........Sahp+.......sKh+.Rh.........ccYTRW..VKoQsCss.C.....G.......KP.AD.......DPHHl...........I.GHG..p.GGMG.T.....Ku.aDlFsL.PLCR....cHHs......E......LHA..s...shuFE..-KaGSQl...LlhRFls+Ahsh..........................................	0	11	27	47
+5976	PF06148	COG2		COG (conserved oligomeric Golgi) complex component, COG2	Finn RD	anon	Pfam-B_9559 (release 9.0)	Family	The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function [1]. The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs [2].	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.47	0.71	-4.28	19	316	2012-10-03 17:31:52	2003-05-30 09:15:08	6	10	269	1	222	448	1	134.30	27	23.60	CHANGED	LsFscspFht................................................ssFssspFlpp.ppptssL-pLpp-LctY.phLcppllcLlNpDYtD.FVsLSssLhGh-cplppl.................cssLtphpcclpuh+splptthpclpsplpc+pplcpp+....phLchLlphtpsls+lEcll	...............................................tpttFht..................................................ssF.D.s...-pFls..........p...s..........c.....+..ts..sL-s...L...+...s...-...Lcth...h....phLpspll-LINcDYsD.Fls.......LSs...sLsG..h.-.....c....t.....lppl..................ps..sL...t...p...h...+.c..c...l..ts.l..+s.p.....l.ppthptlpptlpcpcplcppc.......thlptllpl.hcplpclEph................................................................................................................................	0	73	126	185
+5977	PF06149	DUF969		Protein of unknown function (DUF969)	Finn RD	anon	Pfam-B_9723 (release 9.0)	Family	Family of uncharacterised bacterial membrane proteins.	24.20	24.20	24.30	29.80	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.23	0.70	-5.09	29	934	2009-01-15 18:05:59	2003-05-30 09:23:58	7	2	917	0	119	446	13	214.90	46	92.60	CHANGED	hhsLlGlsllllGFhL+aNslLVVhlAullTGLsAGhshhclLsslGpuFlssRhlolhhLl.LPVIGLLERaGL+E+ApshIs+l+uATsGRlLhlYLllRploAAlGL.uLGGHsQhVRPLlAPMAEuAAcsphG....cLscpp+-+l+AhuAAsDNlGhFFGpslFlAhGulLLhpuhLcph.Ghp.l-shplulauIPTAlsAhlIauhRhhhhD+pLt+	....hlhLlGIsllVlGFhL+hsslLlVhlAGllTuLluGhuhs......clLphlGcsFlssRslslFllh.LPllGLLERaGLK-pAtsLIpKlKuhTsG+lLhlYhhlRplsAAhul.slGGHsQhVRPLls..PMAEuAAc.sphG................cLscc.c-clKAhAAAs-NhGhFFGpslFlAsGulLLlpuhlcph....Gh.c..lp....shplAlhuIPsAlhAllltulphhLhD++Lt+..........	0	26	59	93
+5978	PF06150	ChaB		ChaB	Bateman A	anon	Pfam-B_7743 (release 9.0)	Domain	This family of proteins contain a conserved 60 residue region.  This protein is known as ChaB in E. coli and is found next to ChaA which is a cation transporter protein.  ChaB may be regulate ChaA function in some way.	20.60	20.60	22.50	22.20	19.50	18.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.76	0.72	-4.17	56	786	2009-01-15 18:05:59	2003-05-30 09:37:16	7	2	707	1	126	393	17	63.10	55	67.80	CHANGED	LPtslp.pLPt+ApcIahcsFspuhcpa..ts...........EpsAt+lAWsAV++cYhK.hssc...W..ls+s	..........LP-oV+pVLPuHAQDIY+EAFNSAW-QY..KDttcRR.scsSREETAHKVAWA.AVK+-YtK..s-DDK...W+KKp.............	1	32	76	101
+5979	PF06151	Trehalose_recp		Trehalose receptor	Finn RD	anon	Pfam-B_9846 (release 9.0)	Family	In Drosophila, taste is perceived by gustatory neurons located in sensilla distributed on several different appendages throughout the  body of the animal.  This family represents the taste receptor sensitive to trehalose [1,2].	20.30	20.30	20.40	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.33	0.70	-6.12	8	405	2012-10-01 21:54:26	2003-05-30 09:38:08	8	5	31	0	147	529	0	255.80	24	92.58	CHANGED	Mppot..hcK.........................................pahp.soFHcAluPVLhlAQhFulMPVsGlpup.cPccl+FpWpSlphhaoLlhhlhshschuhuhphVhssulshcolssLlFhlssllsalsFlpLARpWPpIhRpWstVEphhhpssYp.ht+tshu++lpllullllssuLsEHhLhhsSuhh.sshphppCc..hs..shpsYhhpppsplFhlhsYosahshhhcahNsshTFlWNFhDIFlMhluhGLutRFpQLspRlcpht+psMspsaWpclRpcalsLscLlchlDcAlSsllLlShuNNlYFICsQlL+SFpshs.shhctlYFWFSLlaLluRThhlhLsASSIsDEu+csLpsLRpVPocuWCsEVpRFuEpltoDpVALSGh+FFhLTR+LlhuMAGTllTYELVLlQhppsscltp....C	.........................................................................................................................................................................................................................hhhuphhshhPl.sl......ttl.pF.thhs..hhhsh.......h.h....hh........h.h.h.h....h.h..h.p......shph........p............sh.h.h.hhh..h.hh.hu.pW.s.lhh.htth-...h.......ht.......ththtpp...l.hhhhhh....h.hu.........................................................................................................................................................................htph...h.......................................................................h.......+..h.th..hh..hp..t.ht..h..............................................................................................................h.........h.a......h...h....s..h...hhl.R..........h........h...h...s.u.l.......t..................h.........h........................a....t...........p........h......h........h...h.........hsu.t.a.hp...h........................................................	0	46	60	120
+5980	PF06152	Phage_min_cap2		Phage minor capsid protein 2	Finn RD	anon	Pfam-B_9879 (release 9.0)	Family	Family of related phage minor capsid proteins.	21.30	21.30	21.60	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.08	0.70	-5.47	9	238	2009-01-15 18:05:59	2003-05-30 09:44:04	6	7	205	0	35	224	6	309.60	23	78.56	CHANGED	M.....tl..sspph.h.st.hsDlYstLpt-lhsphlcplKsptsh......upshhpWQhpKLsclthLsppslchlu+hoGhspctlpphlcssGhpshpsh-ptlscs.................lppt.........hpshtshl.phLsuYtpQshscL.NhlNpTlLpo......s.tsYpsIIpcT.................sstllsGhKT.ppAlcpsltcahcpGlsu.hlDKuG++WohEuYsRsVl+TTstpsaNchcpc+hc-YGlclshhSpHsuAR.tCuPlQG+ll..ssputsppp.ssK...Y.ul.s....huYGsPuGhhGlNCpHphhPaIsGVsp.....spp.phD.c-stcshphppcQRhhERpI+phKcphhhtcphsDcchhthtpptVRphQstl+thlpss	...........................................................................................................................................................h.phapthp.plh..hhcplht................tp...Wph.phpphthhpp..p.hphlsph.s.stptlpphhp...pthhphhpp..hpp.h...t.........................................httt.....................t......t..pphl...psh....p...ps.hpsh...p.hspsh.tp...............htphYpph.lpcs.................h.hp.h.s.Ghh..oh.ppA.lppsl.hp......hhppGl.s..hhD.p...u.....G.....+...paph-s...Yschslposstpshsphptpthp-h...Gh-..hh.lStHssAR........s........t.........C......u.......hQGclh.........hht.............s.c....a.s.l.s...........hthu...p....ssG.........hhGhNC+Hhhhsah..Glsp...............pp...hs.......c......p......s.....p.............hp...hpppQ..Rh....hERpIRptKcchh....h.tc.th....t.c.......tp................hpthpttlp..thptthpphlpt........................................................	0	15	29	32
+5981	PF06153	DUF970		Protein of unknown function (DUF970)	Finn RD	anon	Pfam-B_9915 (release 9.0)	Family	Family of uncharacterised bacterial proteins.	21.10	21.10	21.10	21.10	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.30	0.72	-4.09	11	826	2012-10-01 21:59:08	2003-05-30 09:47:45	6	1	766	3	149	414	5	106.90	52	98.97	CHANGED	MKLlIAIVQDpDuscLhcuLs-psFcsTKLAoTGGFLKuGNTThlIGlED-+V-cllolIK-sCpsR-plVsshuPhusssDsYlPaPVEVpVGGATVFVlsVEpFhph	................MKlIlAIVQDpDSscLucpLlcss.a.RATKLATTG....GF....L+uGN........TTF.llGl-D-RVD-lLslIcp.sCpsRcQ..hV.o.s......ss.h...s...s.o..s-...u.a....l..PY.PV.EVpVGGATVFVhPV-tFcph..........................	0	68	112	135
+5982	PF06154	YagB_YeeU_YfjZ		YagB/YeeU/YfjZ family	Bateman A	anon	Pfam-B_7771 (release 9.0)	Family	This family of proteins includes three proteins from E. coli YagB, YeeU and YfjZ.  The function of these proteins is unknown.  They are about 120 amino acids in length.	25.00	25.00	27.00	27.00	24.10	23.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.23	0.72	-3.80	10	822	2009-09-10 17:55:17	2003-05-30 09:48:58	6	2	339	6	28	413	9	90.00	81	87.89	CHANGED	sssPpWGLpRslTPpFGARLVQEGNRLHYLADRAGlsGpFS-spsp+L-cAFPphlKQLEhMLtSGELsPRpQHCVTLYpsGLTCEADTLGSaGYVYIAIYPTpt	.....................PphsARLVQEGN+LHYLADRAGIRGtFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPc...................	0	5	7	15
+5983	PF06155	DUF971		Protein of unknown function (DUF971)	Moxon SJ	anon	Pfam-B_10230 (release 9.0)	Family	This family consists of several short bacterial proteins and one sequence (Swiss:Q8RZ62) from Oryza sativa. The function of this family is unknown. 	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.14	0.72	-3.57	109	1053	2009-09-11 11:45:35	2003-05-30 09:50:28	7	18	818	6	442	927	860	84.50	30	39.78	CHANGED	oplplpp.ts.+hLplsasDGp...................p...........hplssEhLRVtSPSAEsp..............GHtsspp..............hh.suKpsVsIpsl-PVGsYAl+lsFsDGH-oGlYoWsYLh	..........................................................................l.hpp..tp.+hLplpass..Gp...................p..hplstchLRshsPuA-sp..............s+ss..spc.....................hh..ss+.psVp..lt..s.l...c...s.l.G.p...YA..l.plsF....s..D...G.Hso.......GlasWsaLh............................................	0	150	254	350
+5984	PF06156	DUF972		Protein of unknown function (DUF972)	Moxon SJ	anon	Pfam-B_10235 (release 9.0)	Family	This family consists of several hypothetical bacterial sequences. The function of this family is unknown.	30.00	30.00	30.00	30.30	29.80	28.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.72	0.72	-3.70	43	1035	2009-01-15 18:05:59	2003-05-30 09:54:09	8	1	1029	0	114	334	1	105.50	41	94.11	CHANGED	M-Kp-la-plsphEppltphhpplspLKppltpllEENspLclENp+LRc+Lpchpt.........................ppppsppt........hucuh-NLt+LYpEGFHICs..haYGp+R.p-E-.ClFCLs	................................MDK+-lF-slsphcppltphhp-lpplKppltpLlEENssLclENpcLRc+Lscl-t...................................tcs.hc..............htcu+-NLtplYpEGFHlCs...aYGp+R..p-E-ChFClp....................	0	36	66	90
+5985	PF06157	DUF973		Protein of unknown function (DUF973)	Moxon SJ	anon	Pfam-B_7947 (release 9.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	21.30	21.30	21.40	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.91	0.70	-5.44	8	109	2009-01-15 18:05:59	2003-05-30 09:57:02	6	3	37	0	58	97	7	227.70	21	91.95	CHANGED	sElpGlpKLRsGsLahlluslluhIshIlhls......................s.h.hhs.h.shltsulhllIlsll...lslluhl+l+SGFsILs.usu+DlGhGtTGshLlllGhllllIGsl...lslh..................lhuh.llaIGsILslIGtILlGluhY+lGchYsssllKlGGILllIsI............lsFIGaILsYlGLscVhsph...............tPhsshps.usplpQVGhGsL+uNGhAplTlYSphpssIlSApI-GTNhpso..pIsPthLpsGpNsIpIpFs.sssshlsGohYhlsLsls...Nu.slplsllYQP	................................................................h.ult.l+pG.lhhhlh.ll.hlh..hhhh..................................................hh..h...h...hhh.hthl......lhl...ls.h.h.h..h.ppGF..Lt.pht...shthG.....hus.l.hl.luhlhhl..huhl...hsl.......................................h......lh...hlu..llh..hlGhlhl.s.h.shhplGpha....p.pshhphuGIlhhlsh.......................................lshlGhI.lhYh...ulspl..ht................................................................................................o.....tl.p..l...sh...h.s..........s..l..G.N.l.h.h........h..tt.Y.l.l..t...s.....h.h.h............................................	1	14	23	48
+5987	PF06159	DUF974		Protein of unknown function (DUF974)	Finn RD	anon	Pfam-B_9042 (release 9.0)	Family	Family of uncharacterised eukaryotic proteins.	25.00	25.00	25.80	26.20	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.76	0.70	-4.92	19	285	2009-01-15 18:05:59	2003-05-30 10:02:37	8	7	233	0	202	302	2	228.30	33	55.68	CHANGED	LsLPpuFGslYLGETFushlsssN......................sospsVpsVslcAEhQTsop......................+lsLtsssss..ssst.........................................lpsspslppllpa-lKE.GsHlLsCoVsYpps.........uGc....p+tFRKhapF.s.psPLsV+TKhtshts..........................chhLEAQlENho..psslhL-pVpL.-ssptapssslsh-sshss..ssph.t..........................................sh.LpPs-.scQhlFhlp.cst................sppstthcspsslGpLsIsWRoshG-+GpLpTupLtpp	..................................................LsLPtsFGslalGE..TFushlslpN.......................ssspsl.pslhl.cA-lQTsop......................+lsLs..ss.s.ss.......ssp.........................................Lpssss.lscllca-lK.......EhGsHlL....sssVoYsst..........................sGc..........................phhFRKhapF...s.hpP.L.sV+TKhhshpst....................................................chaLEAQlpNho..sushh..h-.................pVp..L.-ss..a..pssplN.....sptsp...s..p...............................................sh..L..p.Pt-..spQalaplc.ctt...........................htps.hhhcuh.s.sl.G.cLsIsW+o.shGE+GpLpTupLtp.h..............................................................................................	0	69	106	160
+5988	PF06160	EzrA		Septation ring formation regulator, EzrA 	Finn RD	anon	Pfam-B_9703 (release 9.0)	Family	During the bacterial cell cycle, the tubulin-like cell-division protein  FtsZ polymerises into a ring structure that establishes the location of  the nascent division site.  EzrA modulates the frequency and position of  FtsZ ring formation [1].	32.70	32.70	32.80	32.70	32.40	32.60	hmmbuild  -o /dev/null HMM SEED	560	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.75	0.70	-6.33	37	1051	2009-09-13 07:39:20	2003-05-30 10:10:28	7	3	1032	0	101	562	3	545.60	34	97.35	CHANGED	lllulllllllhhhsshhh+++hhcpIccLEpcKpclhshslp-Elpcl+pLpLsGpopppFccWcpcas-lsssphsclEchlh-AEshscpa+Fh+A+ptlsplcshlsthEpplcpIpptlscLhps-ccNptplpphcctYcpl+KslLspsapaGsuhstlEcpLppl-pcFppFspLspsGDalcAcclLpplccchtpLpphhccIPsllpclpsshPsQLp-LcsGYcchhppsYhhsc.hslcpclpplppplpps.stL.ppL-l-cspppsppIpccIDpLY-lhE+ElpA+phVcpptpplsphlp+spppsppLttEl-+lppsYtLscsElpps+phppclpplppphpphtcplspppssYStlp-phcph.cpLcpIccpQtclpcplpsLcc-EtpA+cplppacpclpplcRhlc+pNLPGlPpsalphhhpsssclcplsccLsph.lNh-plsctLp.spsslcpLcccop-llpsAsLsEpllQYuNRYRspppplppuhpcApplFcp.acYppul-hlupALEplEPGuhcRlpcsY.p	..............................................................................................hlluIllll.l.l..shslth..h.l..R....++.pppp.l-tLE-RKpE.lhsLPls-ElcplKph.p.Lh.Gp.o.pst.FccWppcWs-lospph...uclEppla-AEsh.scpF+Fh+Apptlsphpptls.hEpslppIhpsLs-Lhcp-ccNstclpcsh-hYc-hp+pVhsspcpaGpAhsplEcpLcslpscFspF.sLsssGD.lcAppllsshccchhtLpphh-cIPsLlpchppplPsQLpDLc.t.GY+cLhc.ps..Yphs.c.hcl-pclpplppplcpspttl.ppL.-L-pAptcstplp-cIDslYDlhE+ElcA+chV-pppshlschLp+h+cpNppLtpElpclppsY.hLs-..s-hppl.R..php..s-lpplppsh....pclt.pphpcp.shsYS.lp-pLcpl.cplpsIcccQhcl.......pcpLpplcc-EhpAccplpphpsclcpl+Rhhc+pNLPGlPpsalp.hhhpss...pplccl.ppLppp.INl.cplschlphsssshpsL-ccopcllpsAsLsEpL.lQYuNRYRppcp.....plpcuhscA.clFcp.acYctul-hhupALEplEPGlsp+ltppa.............................................................	0	24	53	77
+5989	PF06161	DUF975		Protein of unknown function (DUF975)	Finn RD	anon	Pfam-B_8494 (release 9.0)	Family	Family of uncharacterised bacterial proteins.	29.20	29.20	29.30	29.40	29.10	29.10	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.88	0.70	-4.63	12	1830	2009-01-15 18:05:59	2003-05-30 10:32:24	6	8	936	0	225	1227	109	171.80	22	89.60	CHANGED	M........oppElKphA+ppL+spWGsslLlhllhhl...........hhhshhlshhtshs.p.h..............llhhllsshlphushhshlcls+p..ppsphppshssF...cpFhphlls.lLhslhhhLaull.hh.h.l.h...................................hhhh..hl.llh.ullhs..htYS.s.alLh-p.c....hGshcAlscStphMKGhKWchFlLpLSFlGW.............................hlLshloh....................Glsh........laLl.........PYhpTsphhFYcsltttp	.............................................................................................................h......th+..t...h...p................hh......h........................................................................................................................................................................hh..h..h....h....h..u.........hh..lth...ct....tp...t....h..t.........h...hh......t.h.........hh.h.....l.h..h.h.h.h..h......................................................................................................................l....h.....h....hh.hhhh.....htat.....s.a.lh...hp.t.p.........hs.....phhptShthMpG.+hph.hhL..Lphls..W.................................................hhLs..h..h....sh..................................u.ls.........................................hhl........................PYh.....hs.h.aYttl.............................................................	0	77	151	182
+5990	PF06162	DUF976		Caenorhabditis elegans protein of unknown function (DUF976)	Moxon SJ	anon	Pfam-B_10032 (release 9.0)	Family	This family consists of several hypothetical Caenorhabditis elegans proteins of unknown function.	24.40	24.40	24.40	24.40	23.30	22.90	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.94	0.71	-4.73	6	29	2012-10-01 19:48:29	2003-05-30 10:42:21	7	3	6	0	27	54	0	151.70	37	68.88	CHANGED	MLSMCN+aPhF-ssc..RhVh.phacllTVFDss.puppPSsAVIVa-ELsKus.ssphLsh.KMEpSYtKVDplspchsspph+aAIHLuSHS.KNsIQIhpoAaSsGYTpcDKcGplPEGsKVKCsGsETsh+TpVsCEcVVK-VNEah-ps+pKFG-Lclpshpc	.................................................hCp.....................sl.VTuFs..s..s.h.Et..p..sPS.ssV.l......DELhKps....ssphl.h..K..h.phuY-cVsc+l....PEL.h.p.p..p.s.chslHLu.sHslcN..sIhhpppAFusGYsppDh.sG.h.lPE.GN.+..s.....p.s.....s.....sp-.....p...sh+oplcC-pLVccVsE+hsLDGp.K.aGGLpVcpS-...............................	0	12	13	27
+5991	PF06163	DUF977		Bacterial protein of unknown function (DUF977)	Moxon SJ	anon	Pfam-B_10135 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins from Escherichia coli and Salmonella typhi. The function of this family is unknown.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.73	0.71	-4.39	3	656	2012-10-04 14:01:12	2003-05-30 10:44:53	6	3	360	0	19	337	25	123.10	59	90.83	CHANGED	MAKPFTQEEREcIKuRIIGLVRcsGRhTlsQLEstTGAsRaosc+hLR-lLAsGDlYpsG+hGlFsSEQAh+sWppAtcKh..........sD.sLIhp.PDGEIRRYDSpQNI...ICsECRKSEVMQ....RVLAFYQGNFQ	..................MAKsFTpEEREcIKupllELVRpSGRcTlRQL..EsKTGATRahhphLuR-LVASGDVYp.SGh..G.lFPSEQAh+DW..ppARcKh...........sDPsLIhpLPDGEIRRYDR+.NI....ICpECRcSEsMQ....RVLAFYpGsh.......................	0	3	9	16
+5993	PF06165	Glyco_transf_36		Glycosyltransferase family 36	Finn RD	anon	Pfam-B_9110 (release 9.0)	Family	The glycosyltransferase family 36 includes cellobiose phosphorylase  (EC:2.4.1.20), cellodextrin phosphorylase (EC:2.4.1.49), chitobiose  phosphorylase (EC:2.4.1.-).  Many members of this family contain two copies of this domain.	20.60	20.60	20.90	20.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.03	0.72	-4.21	116	1154	2010-01-08 16:32:43	2003-05-30 10:48:30	6	29	637	23	350	1064	71	109.20	27	9.38	CHANGED	DssGpahYlRD.poGchWSsohpPs....p.sss...tpYp..spaG.uhupFpppp......sslpsplphh.Vsh-c....ssElp+lpLpNpuscsRplplToYsEh.VLusstsDpup.thophhspo	............................................DpsGcalYl..R...Dtp..........o...G.........c...hWSsohpPs...................p..pss....t.pYc.........sca....GhuaopFppp.t......sslpsphphh.Vs.hcc.....ssElpclplpN...pos..csRp.lplhuYsEh.sL.u.s.h.p.s-ssphhhsph............................	0	112	228	276
+5994	PF06166	DUF979		Protein of unknown function (DUF979)	Moxon SJ	anon	Pfam-B_10323 (release 9.0)	Family	This family consists of several putative bacterial membrane proteins. The function of this family is unclear.	25.00	25.00	63.00	63.00	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-11.96	0.70	-5.46	30	939	2009-01-15 18:05:59	2003-05-30 10:50:52	7	3	918	0	123	458	15	303.60	46	97.51	CHANGED	L-hlYhLhGllhlhhAhhohpD+sp..P+RaGoulFWulhulsFlhGs.................hlPshssGslVlshullAuhttlshGphppsssp...ptcptAp+LGN+LFlPALhlPllollsuhh.hspl................uoLlulGlGsllAlllAhhhT+sp.stpslpEucRLl-ulGWAulLPQhLAsLGslFssAGVGcslupllushlPtssthluVlsYslGMALFThIMGNAFAAFsVhTAGIGlPhllsphGGNPAlhuAlGMhuGaCGTLhTPMAANFNlVPAALLEl+D.+.uVIKsQlPsAlsLLllsIhLMYaLsF	...............-hhYhlhGllhlhsAhhshcD+ss..PpRhGouhFWslhulsFlhGs.................hlPs...hshGhlVllhullAhhptVphGphc.phsc...p...ctptpAp+LtNKlFlPALhlsllsllhuhh.hspl.................................sollululusllAhlsuhhh..T..+sp.PppslpEusRhlpplGhuuILPQlLAsLGslFssAGVGcllu+llusllPs-shFluVhsYslGMsLFThIMGNAFAAFsVlTAGlGlPhllth.GuNPAlhuAluMhuGYCGTLhTPMAANFNlVPAALLEh+D.cNGVIKAQhPsALslLlhpIhLMYhLsF................................	0	26	61	94
+5995	PF06167	Peptidase_M90	DUF980; MtfA;	Glucose-regulated metallo-peptidase M90	Finn RD	anon	Pfam-B_8651 (release 9.0)	Family	MtfA (earlier known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E.coli. Mlc is a repressor of ptsG, and MtfA is found to bind and inactivate Mlc with high affinity [1]. The membrane-bound protein EIICBGlc encoded by the ptsG gene is the major glucose transporter in Escherichia coli. MtfA is found to be a glucose-regulated peptidase [3], whose activity is regulated by binding to Mlc available in the cytoplasm, which in turn has been released from EIICBGlc during times when no glucose is taken up. A physiologically relevant target for this peptidase is not yet known.	20.90	20.90	21.30	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.39	0.70	-5.00	74	1002	2012-10-04 10:46:43	2003-05-30 10:52:23	7	4	957	2	233	631	88	237.40	45	88.21	CHANGED	Mh.......h..............htht+cppltppshs....shWpphlpp.lPhhptLsss-ptcL+phsplFLscKpapGspGlplTDph+lsIAAQACL.lLpls.....hsaYsshppIllYPssFlsppptt.....Dcs..GlVHchcpshsGEuWpp.GPVlLSWpslhtus............st-G....aNVVIHEFAHKLDhhsGs.AsGhPsL....tss.h.......shppWspshppsacphppphptspp...................shlDsYuAssPAEFFAVsoEsFFppPptltppaPplYptLspFY+	.................................................hhhh..................phpcthp..p.pslP......WpcsLs..lPlLssLotpEpt+L.hslAptFLppK+ls.s.....lpGhE.LsshhpspIAhhhCLPlLcLG.....l-Wh-GF+EVLlYPusFVVcccac.....D-hGlVH...stchlpSGpSW.pQ.GPllLsW.DlQcoh............ssuG....aNLlIHEhAHKLDhc..NGc.AsGlP.h.l.........sh.p........-lsuWc+.sLc.s.Ahsslpccl-hss-t.................tusIDsYAAocPAEhFAVlSEYF......FoAP...-LhtscFPuLapphspFYp.........................	1	73	138	190
+5996	PF06168	DUF981		Protein of unknown function (DUF981)	Finn RD	anon	Pfam-B_8691 (release 9.0)	Family	Family of uncharacterised proteins found in bacteria and archaea.	28.50	28.50	29.00	29.80	28.30	28.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.34	0.71	-4.52	13	68	2009-01-15 18:05:59	2003-05-30 10:55:04	6	1	57	0	29	64	5	187.60	30	95.22	CHANGED	Mu.........FIDsLslhLhsLuhshllhAhhhlpshlshc.......cculcsuhhPhh.sLGlhhhloGlauphTW......PLPuSY...NILFhDsahlhGlhlluhululapshc...............LcshuhhuLhlGLhsIhYGssshtasL.Tt-P...............l.AhLuLYhlsGLAulL..ssslhlDphctpt.............lhhllthlhLlluullAhaIGhpAlhuHL..s.sas	..........M...FlDsLslhLhhlshshllhAhhhhtshhsht...............................cpshscshhPhh.slGlhhllhGlauphTW......PLPu...SY....NILFhDsahlhGlslluhululhh.s..hc..........................Lpshuhh..ulhhGLhsIhhGsuhhsauL.TpcP................h.uhLuhahhhGLAulh..ssslhhpp.p.t..............hhhhlhhlhLhluulluhhhGhtuhhuHlst..s.......	0	13	18	24
+5997	PF06169	DUF982		Protein of unknown function (DUF982)	Moxon SJ, Eberhardt R	anon	Pfam-B_10431 (release 9.0)	Family	This family consists of several hypothetical proteins from Rhizobium meliloti, Rhizobium loti and Agrobacterium tumefaciens. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	22.20	22.20	22.20	25.10	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.49	0.72	-4.24	51	308	2009-01-15 18:05:59	2003-05-30 10:56:52	7	2	50	1	157	327	1	74.20	29	77.43	CHANGED	ppPVtlthss.tthp.tlpost-AhchL.pcWPh.p..cG.tapsAl+sCtsAlsGphssppARcAFlsAAccAsl.hh.s	.......t.pPVtlthss..s.thp.plpost-AhchL..pcW.Pt..p..cG.tapsAlcsCtsAlsG..ptsspsARcAFlsAAccAslhh..t..........	0	7	49	64
+5998	PF06170	DUF983		Protein of unknown function (DUF983)	Moxon SJ	anon	Pfam-B_10629 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function.	21.30	21.30	21.30	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-9.95	0.72	-3.87	62	469	2009-01-15 18:05:59	2003-05-30 10:58:27	7	4	239	0	180	411	137	84.30	38	61.56	CHANGED	FcuaLKlsspCssCG.-hsatcusDGPAahsIlllGalllshhlhl-hsapPshWlphsl..ahPlsllhsLhLLpslKGhllulQas	.....FcuFLplsspCssCG.Dasatc....u.sDG.PAahlIl..ll.GallVshhl...hlEhsh.s.s.shWlahsl..ahPhsllh.oLhlLpslKGhlluhQa............	0	50	108	132
+6000	PF06172	Cupin_5	DUF985; 	Cupin superfamily (DUF985)	Finn RD, Bateman A	anon	Pfam-B_9217 (release 9.0)	Family	Family of uncharacterised proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.	25.00	25.00	25.60	25.20	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.87	0.71	-4.27	19	1200	2012-10-10 13:59:34	2003-05-30 11:06:00	6	9	1116	34	350	843	354	132.00	40	81.62	CHANGED	ApplIcpLsLpsHP.EGGaa+ETaRussphs.s..............RshsTuIYFLLsp..sshSpaHRl.cu-EhWHaauGssLplhhhsssGphps.....hpLGhDl.ttGpps......QhlVPsGsWhuu....................ps.ssaoLVGCsVAPGFcFcsFELhc	...................................pphIcpLpLtsHP.EGGaa+cTh+ustphst..............................................RuhhTuIYFL.Lps.........ssh............S+..aHRl.su.DElWa....aa.uGs.sLplahl.s......s......-...G..p...h.ps............................hpLGhDl...tpGp.p.......................QhsVPtGshhuu..............................................pssssau...LVuCh........VuPGF-FccFELh............................	0	101	206	283
+6001	PF06173	DUF986		Protein of unknown function (DUF986)	Moxon SJ	anon	Pfam-B_10711 (release 9.0)	Family	This family consists of several bacterial putative membrane proteins of unknown function.	22.20	22.20	22.30	22.50	21.40	22.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.99	0.71	-4.39	12	608	2009-01-15 18:05:59	2003-05-30 11:09:38	7	1	599	0	47	234	2	144.70	70	97.43	CHANGED	TslhLllhIshhLhYAhYDpFlMsh.hKGKThLpVpLK++s+lDulIFlsLIuILl.YpNhts..pGs.lToaLLssLsLlulYluaIRtP+llFKppGFFauNlFIpYu+I+pMNLSEDGlLVI-L.pp+RLLlplpplcDLEKIhphhsphp	....TDLVLILFIAALLAaAIYDQFIMPR.RNGPTLLuIsLLRRGRlDSVIFVGLIs...ILI.YNNVTs..HGAhlTTWLLSALALMGF.YIFWI..RsPKIIFKQ+GFFFANVWIEYuRIKsMNLSE....DG...VLVMQL.EQRRLLIRVRNIDDLEKIYKLLlss........................	0	4	14	32
+6002	PF06174	DUF987		Protein of unknown function (DUF987)	Finn RD	anon	Pfam-B_9329 (release 9.0)	Family	Family of bacterial proteins that are related to the hypothetical  protein yeeT.	25.00	25.00	36.80	36.70	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.15	0.72	-4.46	3	583	2009-01-15 18:05:59	2003-05-30 11:12:23	6	2	284	0	11	152	0	65.30	91	89.63	CHANGED	M+IIo+tcAMcIaRQHPuSRLFRYCTGKYQWHGSAsHYTGRDVsDIoGVLAVYAERR+DusGPYlc	...............MKIITRGEAMRIHpQ...HPASRL...FPFCTGKYRWHGSAEAYTGREVQDI.PGVLAVFAERRKDSFGPYVR.....	0	4	4	8
+6003	PF06175	MiaE		tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)	Moxon SJ	anon	Pfam-B_10761 (release 9.0)	Family	This family consists of several bacterial tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) proteins. The modified nucleoside 2-methylthio-N-6-isopentenyl adenosine (ms2i6A) is present at position 37 (3' of the anticodon) of tRNAs that read codons beginning with U except tRNA(I,V Ser) in Escherichia coli. Salmonella typhimurium 2-methylthio-cis-ribozeatin (ms2io6A) is found in tRNA, probably in the corresponding species that have ms2i6A in E. coli.  The miaE gene is absent in E. coli, a finding consistent with the absence of the hydroxylated derivative of ms2i6A in this species [1].	20.70	20.70	21.20	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.73	0.70	-5.00	6	1063	2012-10-01 21:25:29	2003-05-30 11:15:23	6	3	665	4	298	910	594	146.00	32	95.80	CHANGED	phLsPlhpFLpCsTPpsWlEpAht.tsLDllLLDHptCEhKAAtoAh.Llt+Ys..................................................PhspcLlschstLh+EEL+HFcQVhplhctRsIshsslsAuRYApuLhutVRTpEPppLlD+LlVGAaIEARSCERFAtLAPaL.DsELAKFYsSLL+SEARHapDYLpLApphuuc.DlScRlphhutlEAELIpoPDsEFRFHS	...................................L....Ts.tWl..s...tp...hL.DHh.CE.KAutsAh.hhhpa.................................................................tL.t.h..lhpEEh.Ha..Vhthh.t+sh.h.......ts.Ystthht.h..p....p...........p..........hh.hD.Llhuuhl.EARSpERhthls..............h.....-......pl.tpaYhtLh.SEupHat.ah.hA.ph.........t..........................ltt+ht.hh.hEtp....ll....t.......t.......phH...........................	0	81	175	256
+6004	PF06176	WaaY		Lipopolysaccharide core biosynthesis protein (WaaY)	Moxon SJ	anon	Pfam-B_10767 (release 9.0)	Family	This family consists of several bacterial lipopolysaccharide core biosynthesis proteins (WaaY or RfaY). The waaY, waaQ, and waaP genes are located in the central operon of the waa (formerly rfa) locus on the chromosome of Escherichia coli. This locus contains genes whose products are involved in the assembly of the core region of the lipopolysaccharide molecule. WaaY is the enzyme that phosphorylates HepII in this system [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.50	0.70	-5.14	4	512	2012-10-02 22:05:25	2003-05-30 11:21:56	6	5	478	0	34	372	53	198.00	52	81.44	CHANGED	MIhpp+I+shsVFhK-NssKYhplhsDFLoYshpslKVFRsIDDTKVhLIDTcYG+hlLKVFuPKsKpsERFhKShlKGDYYEpLhhpTDRVRsEGlpulNDFYLLAERKTLpas+sYIMLIEYIEGVELsDhP-IsE-lKscIppSIcpLHpHGMVSGDPH+GNFIlppstlRIIDLSGK+soApRKAKDRIDLERHYGIKNElKDhGYYhLIY+KKlRphlR+lKGK	.................................................................................................................................MI.p.ph.pshphahccss.hY.plhp-hLshphphlKVhRs.I-.DTKV.L..IsT..th.G.hlhKVauP.Kh.Kh.sERF..h.KS....h....l.K.t...DYYc....pL.hhp.TD.RV...Rs.....EGh.pslN.Da.a.L...LAE.+.K....T....L..p...a....s+h..Y.......lMlIE.........YIEGlcL..s-...h...................-......I.......s......-......-.......l....K......s........c.......l......p.....p.S.....I.....c.......c.....L.....HpH.....GM.....VSGDPH+G.N.F.I.l...p..p..s..t.....lR......lID..L......S..GK..+..s..o..t....h..K......A+..D.R.l..sh..E..R..H.h..sItNp.....l....+D.h.GahhlIa+.pK.l+p..h..l+clKsK..............................................................	1	8	19	25
+6005	PF06177	QueT	DUF988; 	QueT transporter	Moxon SJ, Rodionov D, Bateman A	anon	Pfam-B_10800 (release 9.0)	Family	This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes [1-2], suggesting involvement of the QueT transporters in uptake of a queuosine biosynthetic intermediate.	21.30	21.30	21.40	21.30	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.86	0.71	-4.24	45	1266	2012-10-03 02:46:00	2003-05-30 11:23:59	6	1	1098	0	152	637	4	152.20	33	91.44	CHANGED	slstsAllAAlYllLTlh..lsslSaGslQFRlSEhh.NhLsh...as+.+YIhGlslGshIuNlh.Ss.h....Gll..DllhGshuTLlsshlshhltchhpph.hh.......phhlsslhhslsh.hhIAh.pLshhhp.......l....PF...........hhT....a.holulGEhlsh.llGssllhhlsKplc	..................lsphAll.AAlYllLTlh....lsslS..a.G.shQFRlSEhh..N.hL..sh...ash...KYlhGlslGshluNla....os..h.......Ghl.DllhGshsTllslsls..hhltt...phtt...h..............phhhsulhholsh.h.h..l.Ah...Lsh.hhp...................l......P..F.............ah..o....a....hosulGEhhsh.llGs.lhhhlsK+l................................	0	69	110	132
+6006	PF06178	KdgM		Oligogalacturonate-specific porin protein (KdgM)	Moxon SJ	anon	Pfam-B_10852 (release 9.0)	Family	This family consists of several bacterial proteins which are homologous to the oligogalacturonate-specific porin protein KdgM (Swiss:Q934G3) from Erwinia chrysanthemi. The phytopathogenic Gram-negative bacteria Erwinia chrysanthemi secretes pectinases, which are able to degrade the pectic polymers of plant cell walls, and uses the degradation products as a carbon source for growth. KdgM is a major outer membrane protein, whose synthesis is strongly induced in the presence of pectic derivatives. KdgM behaves like a voltage-dependent porin that is slightly selective for anions and that exhibits fast block in the presence of trigalacturonate. In contrast to most porins, KdgM seems to be monomeric [1].  	20.40	20.40	20.50	21.20	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.56	0.70	-4.84	7	1133	2012-10-03 17:14:37	2003-05-30 11:29:46	8	1	545	2	73	394	5	209.70	33	93.83	CHANGED	lusss.A.shl-hRctYppsoct..cshltlupphspGhGh.l-s......sss.pspt.s-httshNEls.hsh.aKssDphslpPGh.lpstsssSsYpPYL+spYphssshslslRYRapapphous.hcs-pss.ct.chssahsYplhc...paphsap.p.ahcsspap...ussccppaEhssphtY+h.sppWpPYlEls.lshsss....sscR.QsphRVGlpYpF	........................................................................sh.s.A..shl-.Rct....Y....t........sS..ct....cshlt...lu...ph.s.GhGh.l-u.........................sssh.p.sp..+.h..s.-httsssElp.hsYhaKh..s.D.pholpPGh.l.h............c.................ss.Ss..uo.tYt...PYl+lsashs..s..shshulRYRYsa...psh....s.....s...s...s...h............s............u............-.........h...........ss...p....ssa..ch........ssYhsYplss.....cF.sasapsp.h.ahc..s..s.cap...............huNscKa.sa.EhshshpY..+h....s....p...p....apPYhEl.s.....lsppss............sD..cR...Qspa..RlGlpY.F................................................................	0	3	17	46
+6007	PF06179	Med22	SURF5; 	Surfeit locus protein 5 subunit 22 of Mediator complex	Moxon SJ	anon	Pfam-B_10889 (release 9.0)	Family	This family consists of several eukaryotic Surfeit locus protein 5 (SURF5) sequences. The human Surfeit locus has been mapped on chromosome 9q34.1.  The locus includes six tightly clustered housekeeping genes (Surf1-6), and the gene organisation is similar in human, mouse and chicken Surfeit locus.  The Med22 subunit of Mediator complex is part of the essential core head region [2] [3].	21.20	21.20	21.20	21.20	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.44	0.72	-4.03	21	283	2009-09-11 07:34:40	2003-05-30 11:36:54	7	11	233	15	196	266	1	107.50	27	61.35	CHANGED	LL........p+lcpslpslhspFpcllchAp.............................spssphstssp-shthpscssplVRAs-sLLpLscslKEhhIL................ssh.slscshtppppphctcp.p.sp.ltpLh-chhsslhph	..................................................................p+lcsslpslhpsFppllphAp.............................spssphspspp-saphcsc..ussl...lRAuEsLhpLspclKphhlL................schsslsEs.hpp..pppphctpp..tphpp.l.plhcch..phh.........................................	1	61	104	155
+6008	PF06180	CbiK		Cobalt chelatase (CbiK)	Moxon SJ	anon	Pfam-B_10975 (release 9.0)	Family	This family consists of several bacterial cobalt chelatase (CbiK) proteins (EC:4.99.1.-).	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.52	0.70	-5.30	8	718	2012-10-01 23:23:09	2003-05-30 11:41:05	6	9	587	5	138	730	108	247.40	37	87.61	CHANGED	KAILlVoFGToYp-s+chTI-pIE+clscpFPDY-lh+AFTSshI..I+KLKcR-s............lplsTPtpALp+LtcpGYc-VIVQsLHlIPGcEYEclhchV.........pcapssFccl..clGRPlLth.......s-DYcphlcsl+cphs.h..+sEslVaMGHGosHtususYupLsplhcs.psasslaVusVEuYPsl-sVlcclccpshcc.....VpLhPLMlVAGDHApNDMAuD-p-SWKsthcssGhcV.ps......hlcGLGEhcchpsIalcHI+sslp	............................................................pAlLlVSFGToap-opctsIsuhEcclttsa.P-........hclhcAFTSphI...lc+L.cp+cs...............l.p...l.ssPhpALpcLtppGYpc..VhlQsLHlIsGtE.Y-.c.lh.p.p.V......................p.t...h.....c...s..t.....F.p......c.l....plGp.PL.Ls................p.tp.Da.........pplhpA.l................p.........p....p.........hs.....................h............t...p..........scslVhMGHGo.....p...H...........A...........u..s....Y....u.s.L...c...p.hhps......t.s.h...............p...sa...l....GsV..........E..u...a.P..p...l.....-.p.ll...p.pL..+....p....p......s..l..c.p..................VpLhPhMlVAGDHApND......M............A.........u....-...........-..........t.D..................SWK..st..h..ptt.G..h..p.s...p.s....................hL.p.G.LGE.sslpphalpHlcpAh.t................................................................	0	71	113	129
+6009	PF06181	DUF989		Protein of unknown function (DUF989)	Moxon SJ	anon	Pfam-B_11062 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function. The haem-binding domain towards the C-terminus has been merged into Cytochrome_C, Pfam:PF00034.	22.40	22.40	24.10	23.10	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.09	0.70	-5.34	60	485	2009-01-15 18:05:59	2003-05-30 14:07:51	6	4	442	0	164	459	1793	262.90	44	72.00	CHANGED	Mtu....al...h-WlsLhlRWlHVIsuIAWIGuSFYFlhLDtuLpcsss....hpcGlpGEhWtVHGGGFYHlpKYhlAPspMP.Ec.LHWFKWEuYsTWLSGhALLsllYahsAplYLI...DPs.....hh-L.oshtAlululusLslGWllYDhLC+..SsLGc.......psslLullLallllssuauhsplFoGRAAaLHlGAhhuTIMsuNVFhlIhPsQRtlVAslcuGcsPDPp...hGtpAK.RSsHNNYhTLPVlFlMlSNHYPhsauspaNW.lIlullhlhGshIRHaFNt+Hss.....p.ppshashsusshlhslhhhluss	...............................uhhh-Wlshhl.RWlHVlsuIAWIGuSFYFlhLD..u.Lpp.ss....h.pGs.G-.WtVHGGGFYphpKYhlAPspMP..-cLpWFKWEuYsTWlSGhsLLhllYhhssshYLlD.s.....h.h.sh....u.sh..Altlulu.LshGWllYshlCc........LGp...........psthLhlll.hhhllshuashs.p.....l..FoG.R.AA..a..LtlGAhhuTIMsuNVFhlIhPsQ+tlVu....s...lhs.....GcpPDPt......hG...ctuK.R...ShHNsYhTLPVlFhM.....l.S.N.HYs.hsauspaNW.l.lhsllhlhGshIRpaFsh+..Htt.....p.t..hhshhs.sshhhhhh.hhht.s.............................................	0	34	89	125
+6010	PF06182	ABC2_membrane_6	DUF990;	ABC-2 family transporter protein	Moxon SJ, Eberhardt R	anon	Pfam-B_11079 (release 9.0)	Family	This family acts as the transmembrane domain (TMD) of ABC transporters [1,2]. The family includes proteins responsible for the transport of herbicides [1].	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.43	0.70	-4.81	12	2005	2012-10-03 10:13:34	2003-05-30 14:10:04	6	3	813	0	438	1383	277	223.40	23	87.05	CHANGED	llhhssshhhhhllapp..sssluGWsht-hlhlhGh....hhlhpslhshhhtsshtclscpVccGshDhhLLKPlshhh.lhhcphs.htlhcl.......lhGhhLlsYsshhlslshTshpllhhllsllsGslIhhulhhhhushuFWhhcs.thh.tlhhul...hshupaPhshasthl+hhhsFllPhshhshhPAphhLG+hsh....hhhlhs.hlhullhhslothhWptGlcpYpSsG	......................................................h....hhshhhhtslapp......hs.lp....G......aohpphhhhhhh.........hlsph.l.tp.h.h.h...s...h.h.hhsc..l.+....cGplshhLlRPls........h....hphl...h....pp...h....s.........p...h....l.h.h.l..............hlu..h..l..l.l..h..h..h..h..........t.......h.......s...l..s......h.....s..h...h...p....h.......l..l....a.l....l..sl...hhu..h.l.l.hhtl...plhhu..........hhu.Fah.pp...h...t...u...h...h...h...l...h...hsh...hs.h.uh...h..Plsha.....s.....p....h....lp..hl..l..sa...lPFuh.hsahPsthh...l..s.c.h.ss................hh.s..l.h.h.....hh...hsllh.hslu.hhlWcpulcpaputG.....................................................	0	170	299	381
+6011	PF06183	DinI		DinI-like family	Bateman A	anon	Pfam-B_3085 (release 9.0)	Family	This family of short proteins includes DNA-damage-inducible protein I (DinI) and related proteins. The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co- protease activity of RecA. Escherichia coli DinI, a LexA-regulated SOS gene product, shuts off the initiation of the SOS response when overexpressed in vivo. Biochemical and genetic studies indicated that DinI physically interacts with RecA to inhibit its co-protease activity [1]. The structure of DinI is known [2].	20.30	20.30	20.70	20.40	19.90	18.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.06	0.72	-3.95	11	1722	2009-09-11 10:20:43	2003-05-30 14:12:56	8	2	573	1	94	517	4	64.00	40	80.24	CHANGED	lPsGul-ALpsELp+RlpppaP-..stVpV+tuSusuLSlsGsscc-..KchlpplLpEhWEs.DsWhs	..................hssGAl-ALtsELo.+RlpttaP-..spV.pV+.h.s.uu.ssLolssspc--..KpplpchLpEsWEsADpWhh........	1	1	15	53
+6012	PF06184	Potex_coat		Potexvirus coat protein	Moxon SJ	anon	Pfam-B_11093 (release 9.0)	Family	This family consists of several Potexvirus coat proteins.	25.00	25.00	164.00	163.80	19.80	17.20	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.98	0.71	-4.85	2	45	2009-01-15 18:05:59	2003-05-30 14:13:12	6	1	3	5	0	45	0	148.20	92	83.07	CHANGED	hstRpNRRttSRsutho...DhhYsoLT.tuTToapRpsFPsLtsMGDRsFQVluhpI.ssSAuPhhYpARLYsPtDsDsVtuTGlQh.GTsPRThRhpshsGQNsWF.GNTppspsIlAIDGLhoppusssPpNsVhVphsaRlAPSELQSu	MVGRRNRRQRSRVSQMT...DIMYGSLTLGSTTTWTRKNFPGLANMGDRPFQVISAKIVVSSASPMLYQARLYSPHDDDNVGSTGLQMSGTTPRTHRMRALPGQNTWFSGNTSSTQVIVAIDGLKTKToDVTPQNAVAVQISYRVAPSELQSA....	0	0	0	0
+6013	PF06185	YecM	DUF991; 	YecM protein	Moxon SJ, Bateman A	anon	Pfam-B_11108 (release 9.0)	Family	This family consists of several bacterial YecM proteins of unknown function.	25.00	25.00	44.80	43.70	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.33	0.71	-5.07	6	775	2012-10-02 15:00:03	2003-05-30 14:16:58	7	2	766	1	89	341	6	181.20	59	95.31	CHANGED	spp.shpplhpcLssF.pKIppLuchLsLDLothphDHIALRVNspQoAchhppha.cpGcllS-NhINGRsIhlIcL-pPLphusapI-slELPaPup.KpYPpEGWEHIElVlPupsps...hspchhthhstls.papt.ppsslpVKlSSPKuEGERLsNPTIAhpa.....sssCIKlHPauIKcIlcSE	..........................p.h-ELpDluuDLPRFppAlccLupRLGL......sl.osLpADHISLRCHQNsTAERWR+GFpQCG.ELLS.ENhINGRPICLFKLcEPV.........pVu.......HWp.........hsllELPWPGE.KRYPHEGWEHIEIVLPG..-PET....LsAR..A.LA..LL......oD.............-....G...........L...................o..PGIsVKTSSPKGE+ERLPNPTLAVTD......G+sTIKFHPaSIcpIVASE.........................................	0	11	29	61
+6014	PF06186	DUF992		Protein of unknown function (DUF992)	Moxon SJ	anon	Pfam-B_11128 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.20	21.20	21.60	34.60	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.75	0.71	-4.86	29	199	2009-01-15 18:05:59	2003-05-30 14:18:40	6	1	134	0	76	154	10	145.90	43	86.49	CHANGED	sussuhssssssssspst.lclGsLpCps..suusGallGSsppLsCsFpsp..utss-tYsGslp.+hGLDlGhTppothsWuVhAP..ssphspGsLuGsYsGsuAsAolGlGlGANlLVG.GospuluLQPlSlpuQsGlNlAsGlsplpLp	.........ss.hhshssss.s.usp.spst.sclGhLsCcl..usulGhllGSspclsClF...+spt.sss.-pYsGsIp.KlGlDlGhTspupLuWuVaAP..ssshstGuLsGpYsGAoAsAulGlGhGuNlLsG.GStpoIuLQPlSVQGQpGLNlAsGlssLpLp.......	0	11	33	47
+6015	PF06187	DUF993		Protein of unknown function (DUF993)	Moxon SJ	anon	Pfam-B_11260 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	24.00	24.00	26.20	27.00	21.40	23.70	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.30	0.70	-5.93	21	227	2012-10-03 05:58:16	2003-05-30 14:21:26	6	2	203	1	82	200	28	375.10	58	98.45	CHANGED	ltLPssDGslcsYpLtusshh...tsssuPh.....huRlAaAAAHVVADPhusscPh.ussulDW-uTLAFR+aLWsLGLGVAEAMDTAQRGMGLDWssApELIcRShuEApuh........uup.....lAsGsGTDHLs....PusstsL-sVlsAYcEQlssVEtsGG+lILMASRALAtsA+uPDDYtcVYu+lLspsccPVILHWLG-MFDPALpGYWGSs-hcsAh-TsLslItspusKVDGIKlSLLDps+ElshRcRLPcGVRhYTGDDFNYsELItGDsptaScALLGIFDAIAPAAStALpsLspGDsspa+slL-PTVPLSR+IFcAPTpaYKTGlVFLAWLNGaQsHFpMlGGhpSuRulsHhA-lFRLADpAGLLsDP-lAstRM+tlLult.Gl	.........................lpLPsscuslpsYpLtus.ss...ts...t..ssPt.....hsRlAaAAAHVVuDPhsDssPh.sssAlDW-AThAFR+HLWuLGLGVAEAMDTAQRGMGLsWsuApELIRRShAEA+ss......GAc...........lAsGsGTDHLs......................suts...tsL--VlcAYEEQluhlEptGGRhILMASRALApsA+uPDDYh+VYu+lLuQsccPVlLHWLG-MFDPuLcGYWG.Sp..ch-sAhcTslslIpspssKVDGIKISLLDtc+E...lslRpRLP.......c....GV+hYTGDDFNYsELIt......GDs......p............taSHALLGIFDAlAPtASsAlssLssGDsppF+ull-PTVPLSR+IFcAPTpaYKTGlVFLAWLNGHQsHFsMluGhQSsRulhHhA-lFRLADpAslLscP-LAspRM+pLLAlaGl.............	0	21	52	68
+6016	PF06188	HrpE		HrpE/YscL/FliH and V-type ATPase subunit E	Moxon SJ	anon	Pfam-B_11055 (release 9.0)	Family	This is a prokaryotic family that contains proteins of the FliH and HrpE/YscL family.\	  These proteins are involved in type III secretion, which is the process that drives flagellar biosynthesis and mediates bacterial-eukaryotic interactions [1-2].  This family also V-type ATPase subunit E.     This subunit appears to form a tight interaction with subunit G in the F0 complex [3]. Subunits E and G may act together as stators to prevent certain subunits from rotating with the central rotary element [3].  Pfam:PF01991 also contains V-type ATPase subunit E proteins.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.19	0.71	-4.55	10	187	2012-10-02 21:03:42	2003-05-30 14:28:14	7	1	172	0	31	328	31	164.80	25	79.76	CHANGED	MLs+RpIsLs.ususL.pPllRREpLAsshpAcslLp-ARpQA-plLspAcpcA-thpp....pApApFWppAsuhLpslQpQREplpppsloss-pLLspA.LppLLDETspupRhpALLRQLlsuQhsEusATLhCHPsptssVAcWLsspu.phtWpLpsDsoLssDoL+LsTApGsFslsWsshpctLl	.......................................................................................s...llptt.Ls.p.phpApsl.LppA.+p...QApp...llppAcpc..A.ptlhp......pu..t...p....pA....tp.h....h.......p...............p.....ss...s.h....Lt...t....hp..tp.t....-s.L....p.p....tl........h.p....t.spc....llp..p.u.L...p...plL.c.c.s...s.......t.t......p......h..p.t.L...l.pp...L.....h....tt...................h....l...h..t..s...............................................................................................h...............................................................................................................	0	10	19	26
+6017	PF06189	5-nucleotidase		5'-nucleotidase	Moxon SJ	anon	Pfam-B_10008 (release 9.0)	Family	This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).	20.20	20.20	20.20	30.30	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.69	0.70	-5.58	43	426	2009-01-15 18:05:59	2003-05-30 14:40:48	7	3	318	0	174	428	360	259.30	45	76.67	CHANGED	cYQh-+EspsLpPGsAFPhV++LLulNpthtp.........p.hVEVVLLSRNss-TGLRVFsSIpHYGLs.IoRAsFouGcSPapYlsAasssLFLSustpDVppAlcsGhsAApllsssspssp..............ssp.LRI......................AFDGDAVLFSDEoEplappp.G...LcAFpcpEpppsppPLssGPa+sFLtsLpplQpp...........h....ss..hpsPIRTALVTARuAPAH.ERVI+TLRsWslclDEAhFLGGlsKuphLcsapscIFFDDQpsHl-uAu..ptlsouHVP.aGluNp	........................................pYQhp+Esp.LpPGsAFshV+..................tLLslNpp..htp...........p.hV..EVVLlS..RN.sspoG.l..RlhNSIpHYuLs..IsRusFTuGcuPhs.YlcAatssLFLSussc-VpcAlpt.GhuAAs..lh.ssst...p.t.stt..............ssp.LRl......................AFDGDAVLFSDEoEplappp.G.........LcsFhpaEptptspPLstGPh+sFLpsLscLQpp...h..........sp....psPIRTuLVTARSAPuc.tRsl+TLRpWGlclD.EAhFLGGhsKushLcthpPcIFFDDQhhHl-uAp..ttssuuHVPaGlsp.................	0	31	73	120
+6019	PF06191	DUF995		Protein of unknown function (DUF995)	Finn RD	anon	Pfam-B_11307 (release 9.0)	Family	Family of uncharacterised Proteobacteria proteins.	19.50	19.50	19.60	19.80	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.36	0.71	-4.82	14	170	2009-01-15 18:05:59	2003-05-30 14:50:04	7	4	93	0	32	83	2	145.20	43	80.92	CHANGED	sshlLssulsususstusssss....sApshousElaplYpsKoWhWcs...GAGYFsscsRpFpAWopcssutSaupGRWhlossGpLChcAsW+spsGsusupT.....CFsHRpts.GsIYQ+R-PDGsWYVF++ssspssDEatKLhcuDhVu	.............................................sslLLhussuhAsss.tus...sspct..huspsMoAhcLhpLYts+oWpWsD...GuG..Y...aosK..........c+...pFsAhscpssu+SaupGRWhlTDsG+lChKAtW..psttGs.....s....s.Ap.T.....CFtHRht.D.GslYQ....+.+ps..s.GpWYVFRHsPhQcsDEApKLlpuDhl...............................................	1	2	14	19
+6021	PF06193	Orthopox_A5L		Orthopoxvirus A5L protein-like	Moxon SJ	anon	Pfam-B_10342 (release 9.0)	Family	This family includes several Orthopoxvirus A5L proteins. The vaccinia virus WR A5L open reading frame (corresponding to open reading frame A4L in vaccinia virus Copenhagen) encodes an immunodominant late protein found in the core of the vaccinia virion. The A5 protein appears to be required for the immature virion to form the brick-shaped intracellular mature virion [1].	22.40	22.40	22.60	22.40	21.30	22.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.23	0.71	-4.31	13	77	2009-01-15 18:05:59	2003-05-30 14:53:24	6	1	37	0	0	67	3	234.50	51	91.58	CHANGED	MDFhsKaSptLspoupsKss...hhhp-Ehssss++spsl-htLKSpEphYQ+QLREQLA+cNMhtssctsI...............................................Ppp.tTNooSshsNl....puDss.spsoSll...p..sulpDIlpcas......................................................................................SVcc-hppLQsEos-LVosltsAREhThcAIspIh.pLsKtFp..phpc	......................MDFFNKFSQGLAESSTPKSS...IYYSEEKD.sDpKKDEAIEIGLKSQESYYQRQLREQLARD.NMhsASRQPIQPLQPTIHITP....................................L.ssosAPTPKPRQ.QTNTSSDMSNLFDWLSsDss.s.sSSLLPALTP.NuVQDIISKFNKDQKTTTsPSTQPSQTLPTTTCTQQSDGsISCTTPTVTP.QP...shsssssTPTssssssssptp.NPGAsSQQNLDsMuLKDLMSsVE+DM+QLQAETNDLVTNVhD.AREY...TRRAIDQIL.QLVKGFE..RFQK.......................................	0	0	0	0
+6022	PF06194	Phage_Orf51		Phage Conserved Open Reading Frame 51	Finn RD	anon	Pfam-B_11352 (release 9.0)	Family	Family of conserved bacteriophage open reading frames.	21.10	21.10	21.10	50.20	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.97	0.72	-3.88	3	378	2009-01-15 18:05:59	2003-05-30 14:54:32	6	1	199	0	3	179	0	75.10	89	98.57	CHANGED	MTD.SssKEYLNQFFGSKRYLYQDNERVAHIHVVNGTYYFHGHIVPGWQGVKKTFDTAEELEsYlKp.HGL+aEEuKQLoLF	....MTD.sARKEYLNQFFGSKRYLYQDNERVAHIHVVNGTYYFHGHIVPGWQGVKKTFDTAEELE.hYIKQ.HGLEYEEQKQLTLF..	1	3	3	3
+6023	PF06195	DUF996		Protein of unknown function (DUF996)	Finn RD	anon	Pfam-B_11375 (release 9.0)	Family	Family of uncharacterised bacterial and archaeal proteins.	26.00	26.00	26.30	26.90	25.30	25.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.86	0.71	-4.18	16	81	2009-01-15 18:05:59	2003-05-30 14:56:10	8	2	55	0	50	89	2	129.20	25	69.88	CHANGED	llullGhVLlLlulttlScths-cclFppaLhuhIhslluhllhhshlh.....huhhhhps.hsshhs.h.hhsh..lhshLushlllallhlluu.......YFh++AactluphoGlshFcpAuhlhaIGAlLhllh.lGhlIllluhI	................lullGhlLlLlulttlucthscpclFpphLhuhIlsll.uhllhhlhhh.................hthhhh.h......h.....h.........h.sh..............hsshlsshllha....lhhllus..........hah++uachluphoGhshFpsuuhhhhhGAlLhlll.lGhllhhluhI................	0	15	24	34
+6024	PF06196	DUF997		Protein of unknown function (DUF997)	Finn RD	anon	Pfam-B_11382 (release 9.0)	Family	Family of predicted bacterial membrane protein with unknown function.	20.70	20.70	21.00	22.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.92	0.72	-4.47	24	837	2009-01-15 18:05:59	2003-05-30 14:58:27	7	1	834	0	88	313	6	75.50	55	89.98	CHANGED	pQApKEAhaAluLsllYhlhWhlhAYh.susss.......hhGFPhWF.hSCIhhPllFhllsahhVKhlF+DlsL-csp.ps	....l.QAHKEARWA..LuLTL.lYLAsWllsAYLP.G.s.u.sG............hTGhPcWFEhACILsPLlFIhLCWhMVKFIa.RDIsLED-D..ut........	1	16	39	63
+6025	PF06197	DUF998		Protein of unknown function (DUF998)	Finn RD	anon	Pfam-B_11425 (release 9.0)	Family	Family of conserved archaeal proteins.	27.00	27.00	27.00	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.46	0.71	-4.98	111	925	2012-10-01 21:22:51	2003-05-30 15:01:43	8	6	680	0	301	768	89	184.90	17	80.56	CHANGED	llusslhhhs..hlhsthhhsua.shhppslS-Lus..........sstsalh..ssuhlhhulhhls..hulhhhh.....ttshttphushlls...lhulu.hhhsG..lastsss.....................hH.hhsuhlsalthslusl....lhu..................hhhthhphhtsluhhhhhsshhhhhhs..................hhGlhpRhhshsh.hsWlhhhuht	...................................h.hsshhhhhs...hhhtt.hh..ts..s.h..s.....hppslStLusht...................ushthha..p.hshllsGh.hhlh..........hshhlhtt................ttph...h.tthss..sh..ls...................hhGlu..hlhsG....lash.sss........................thlH..shs.u....h...l....sh...hshhlshl...........lhs.................h.htt..ht.h..hph.hh.h.lshlhhhhsslhhhst...........................h.h.hGlhpRl.shhhh..hhahhhhs..h............................................	0	104	188	251
+6026	PF06198	DUF999		Protein of unknown function (DUF999)	Finn RD	anon	Pfam-B_11426 (release 9.0)	Family	Family of conserved Schizosaccharomyces pombe proteins with  unknown function.	25.00	25.00	258.50	257.50	19.30	18.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.88	0.71	-4.41	3	9	2009-01-15 18:05:59	2003-05-30 15:35:05	6	1	1	0	9	8	0	141.20	83	55.62	CHANGED	MVEDVCNVDLEQGLDLCKPEKVNKQSQRSRQSRQSLFTNTIKPQKDKMNIKTNKIKEFLNDLFTEFSKFHNSYYPDGRISTRSKhRWPLLIIWSIIIVFAIDKKFEVK-FLSIW.....INENRFYSEIWGPIAIYVCLFVLLLLuLI	MVcDspNVDLEpGL-LCKPEKVNK.........QsLFTNhIKPQKDKhNIKTsKIK.FLNsLFTEFSKFHsShYPDGRISTRSphRWPLLIIWsIlIVFAlDKpFEVpcFLSIW.....INENRFYSEIWsPIAIYlCLhVLhLLuLI	0	9	9	9
+6027	PF06199	Phage_tail_2		Phage major tail protein 2	Finn RD	anon	Pfam-B_11427 (release 9.0)	Family	Characterised members are major tail proteins from various phage, including lactococcal temperate bacteriophage TP901-1.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.45	0.71	-4.10	63	727	2009-01-15 18:05:59	2003-05-30 15:44:01	6	8	629	0	118	479	169	135.50	20	78.71	CHANGED	stpG+Dllltlphsss...s....tatplushpspslshsu-sl-so...op-......s.sthtphlsssGsppsolSusGl.ht.s..s...ssppplcptahsuphsc........apl.................h...hsshu.............p..hpGsah...loul-hu.ustsspsoaslshsusGtlsh	....................................................................pGcDhllhhphsst..t......shhphuh.p.spp.ls.hs.t-ossss....opD.............................thltssGs.hps.o.lSssul..hp.s....c.........stsptlccshhssthh-.........acl.........................t...hssts.................p....hpu.ah.......lsuhphs.ust-shsphphphsssGthp.....................................................................	0	35	76	96
+6028	PF06200	tify	Zim; 	tify domain	Bateman A	anon	Pfam-B_3326 (release 9.0)	Domain	This short possible domain is found in a variety of plant transcription factors that contain GATA domains as well as other motifs. Although previously known as the Zim domain this is now called the tify domain after its most conserved amino acids. TIFY proteins can be further classified into two groups depending on the presence (group I) or absence (group II) of a C2C2-GATA domain. Functional annotation of these proteins is still poor, but several screens revealed a link between TIFY proteins of group II and jasmonic acid-related stress response.	20.90	20.90	22.90	21.50	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.17	0.72	-7.26	0.72	-4.69	48	482	2009-09-14 12:07:42	2003-05-30 15:52:11	9	12	39	0	250	488	0	35.50	41	13.34	CHANGED	ssssssQLTIFYuGpVhVF-slss-..KAptlhplAup	...........stssQLTIFYsGpVhVF.Dslss-..KA.pslhhLAu...............	3	42	154	208
+6029	PF06201	PITH	DUF1000; Thioredox_dimer;	PITH domain	Yeats C	anon	ADDA_10869	Domain	This family was formerly known as DUF1000. The full-length, Txnl1, protein which is a probable component of the 26S proteasome, uses its C-terminal, PITH, domain to associate specifically with the 26S proteasome. PITH derives from proteasome-interacting thioredoxin domain.	23.70	23.70	25.60	25.00	22.10	22.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.96	0.71	-4.44	56	613	2012-10-03 19:46:52	2003-05-30 16:00:39	8	18	298	2	434	619	10	146.30	31	56.41	CHANGED	sLhspIDhsplpsLNp.....sss....susttslhcshppc.t...............hlpS.Ds.......D.-QLllpIP..Fss.slKl+Slhl.p..u....................ssspsPpplKlFhN..ppslsF-ssp.shpssQslc.................Lsp.......shpshhphs....L+hs+FpsVpsLolal..........psN.u...s-pT+ItaIslhGps	......................................LhshI-hsplpsL..Nc.......................ssp..........tuht...slhcshp.p......................alcS..D..s........D.EQLllplP..Fss.sVKl+.Slhlpus.........................ssspsP+plKlFh..N..tpshsF-sup...shp....Ps...Qslp..............................Lsp..............shpssh.phs....L+.hs.+Fp.sVps......Lo.lFh................psN.G........t-pT+ltalslhGp...................................	0	153	247	362
+6030	PF06202	GDE_C		Amylo-alpha-1,6-glucosidase 	Bateman A	anon	Pfam-B_3607 (release 9.0)	Family	This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homologue Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33).	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.53	0.70	-5.74	14	1196	2012-10-03 02:33:51	2003-05-30 16:24:27	9	30	973	0	546	1693	78	369.30	22	41.39	CHANGED	huospFlscp..........................t.ts.ollAGa.WFu....c.WGRDohIuLsGlhLlsGRa--A+sllhsFuphh+.......+GLIPNthss.sspsh....YNosDAoLWalpulpcYhchssD.hthL....pchaP......................slppIlpsahpGsca....................sltlD.pcuLlhsGs...shTWMD.......AtlsGh.slTPRsGpslEINALWYsAL....+hhpphup.hltc.............tpppYpplApplpssFc+tF...hs.................................................................................scpshlhDslsssp.....pDhplRPN.lhAloL.....s...slhss-pt.thlchspcpLLsPaGL+TLsPcD.sYpGhYsG.sp.sRDtA......YHpGTlWsWllGhalcAhh+hspp...ppt...........ls.hpslLp.h.tal.pushuslsEla-....u-ssasspGChsQAWSVuEllR	...............................................................................................................................................................h.................................hhAGhPaFs.....p..aGRD.s.h.I....u.h.......u..l..h..Lh...s..t......p.....p.............u.c.t.h.l.....h......t.h.s.t..h...t..........................G.h...l.......sp..h..t........t........sp.........t..st...................Y......s....s....s..D..ushaalhs..ltpY...hch....s.s...-....hphl.......pch.h.P..................................................................................................h.lp.p.h...l...p....h...h.......h.....p.....u.....h.p.............................................................p.h.thc.......p.s.....u..h.....l....h....t....s....s....t.....h.........s....ts..W...h...D..................................st....p.s.h....shs.P....c..t..s....t......s....l.E.......l..pu.h.hY.s.A.l.......ph.hu..p.l.s.p..t.h.h.t.t........................................................hstp...h..p..phApplc.p...sF..pc.tF....hs.................................................................................tc..t.s.hh.t...p...h..l.cst.p...........ts.h...p.l.R...s...N.......h.....h.....s....h..s.....l...........................s.........sl.h..s.......c...p.s...t...p...s...l....c..h...h.....p...p...p...L..h..s...s.....h....Gl....R....T..L..ss.................p..................p..h..s..................Y.p...s........................hu......................YHpGshWs...a.huhhhpuhh+.hsh...............................................................hp..h.t..t.hht......h........t..h......t.t......t.........ht...tls.E...l...hs.........ts.s.......s.....h.......h.......s..hus...sQAWusuth..............................................................................................................................................................................................	0	183	334	452
+6031	PF06203	CCT		CCT motif	Bateman A	anon	Pfam-B_314 (release 9.0)	Motif	This short motif is found in a number of plant proteins. It is rich in basic amino acids and has been called a CCT motif after Co, Col and Toc1 [1]. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif [1]. Toc1 mutants have been identified in this region.	20.60	20.60	20.60	20.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.14	0.72	-4.33	42	1411	2012-10-01 19:54:00	2003-05-30 16:45:03	9	19	143	0	549	1397	13	44.30	54	10.78	CHANGED	Rcspl..hRY+-KR+pRpFsKpIRYtsRKthA-pRsRlKGRFs+psp	.............RcApl..hRYREKRKp...R........p..F.....c..K..+....I.....R........Yt....oRKt........hAEpRPRl+.GRFs+ps.s.......	0	133	347	463
+6032	PF06204	CBM_X		Putative carbohydrate binding domain  	Finn RD	anon	Pfam-B_9110 (release 9.0)	Family	\N	21.10	21.10	21.10	21.40	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-9.20	0.72	-4.49	57	1056	2009-01-15 18:05:59	2003-05-30 17:12:43	6	25	595	23	316	973	50	63.10	32	5.20	CHANGED	sshGsFssss+EYl........hhlhss.pT.....PsPWlNlluNspaGhhlSpsGuGYoahpsu+phclT.WpsDsl	........................thGhFsppspEYl................h.sp.ssT.................PtPWsNlLuNs.paushlSssGuG...Yo.a.tss+phplT+acsDss.......	0	99	204	247
+6033	PF06205	GT36_AF		Glycosyltransferase 36 associated family  	Finn RD	anon	Pfam-B_9110 (release 9.0)	Family	\N	21.00	21.00	21.00	21.50	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.82	0.72	-4.24	111	1114	2009-09-11 09:10:52	2003-06-02 09:55:43	6	25	623	23	331	1025	61	89.50	26	7.62	CHANGED	upstas...phspthAah.sss.....tstsuassDRscFlGRstslssPtAl....tpstLSsosGsslDPsuulptplpLtPGcptclsFhlGhupspcp	.......................................p..p.thtp.hsah..sss...............tpssua-sDRppFlGp..s..psh...........ss......PtAl................ttspLos.os..us...shDPsuulp.t.p.l.p.LtPGcptclsFllGhupspp.t.....	0	103	213	259
+6034	PF06206	CpeT	DUF1001; 	CpeT/CpcT family (DUF1001)	Moxon SJ, Bateman A	anon	Pfam-B_11004 (release 9.0)	Family	This family consists of proteins of proteins belonging to the CpeT/CpcT family. These proteins are around 200 amino acids in length.  The proteins contain a conserved motif PYR in the amino terminal half of the protein that may be functionally important. The species distribution of the family is interesting.  So far it is restricted to cyanobacteria, cryptomonads and plants. It has been shown that CpcT encodes a bilin lyase responsible for attachment of phycocyanobilin to the beta subunit of phycocyanin [1].	20.30	20.30	20.40	20.80	19.90	20.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.94	0.71	-4.61	51	207	2009-01-15 18:05:59	2003-06-02 10:29:07	6	2	125	0	80	226	183	162.10	27	83.45	CHANGED	hphschLuGcaoNppQAhcs.......PshaA+IplhaR..PLs.....h.hhpuhuhasEQsYshsstpPYRp+lh+lh.p....sstlhlcNaslc-spcatGAupc.sc..hLpplss-sLphh.pGCs..hhhpppss.t....apGplEPGppChl.R.cGptTYLsSphcl...spp.phhShDRGaDscTccplWGShsG.PacFp+	.......htlsphhsGcasNppQAhps.........P..sh..aspl.clhhc..Pls............h..s......shshahEQ.saths..ppPYR.Rlhclh.s......pspl.lpsYtlcc..p..pahusspc..p........hhptls..p.....plt.h...sCs..hhh.phpsp..s.............apGpspPGptChs.p...pGptoalsophpl....ppp..phhohD+GhD.psspplWGuhtG.sacFp+..........................................	2	18	50	71
+6035	PF06207	DUF1002		Protein of unknown function (DUF1002)	Moxon SJ, Bateman A	anon	Pfam-B_10868 (release 9.0)	Family	This protein family has no known function. Its members are about 300 amino acids in length. It has so far been detected in Firmicute bacteria and some archaebacteria.	23.80	23.80	25.30	24.90	23.60	22.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.30	0.70	-5.03	47	783	2009-01-15 18:05:59	2003-06-02 10:30:15	6	2	723	0	105	508	7	227.60	38	70.76	CHANGED	LGtsLoppQ..KpphLchh.....s.stsssphlpVTsp-.pcYLsshssp.tphuopshSSuhlphpspG.......pGlpVcs......pNIThVTspMYtNAhlTAGlpcAplhVsAPhtVoGouALTGlhKAaE...us.GpplspcpKpsAs-Elsssupl.......s-shup-csssllsclKc-lscpp..p.....ocp-lppIVpphhpphsls....Lossphspllslhtclpshslsh...sphps....QLsp.lp	.................................LGsuLo-sQ..KppsLctL.....sssc..st...plhTlTssshsKhhs.sss....ss....uhphaSSuhIpphsss.......sGlpVcI.s....cNITpVTpsMYpNAAlTuGlccAcIpVuA...Phs..VoGpuALsGlYtuhE....ss.GtplsppsKclApEELpshSslsttp.......pscss.h.s.s.sKLssAlA-IKptlAKtp.ps.....hTc-Dl+..pIVcc...s....lcshsls......lTssQls.Ilshhhp.lppssl.p....ssshsppLscl....................................	0	32	63	82
+6036	PF06208	BDV_G		Borna disease virus G protein	Moxon SJ	anon	Pfam-B_10516 (release 9.0)	Family	This family consists of Borna disease virus G glycoprotein sequences. Borna disease virus (BDV) infection produces a variety of clinical diseases, from behavioural illnesses to classical fatal encephalitis [1]. G protein is important for viral entry into the host cell [2,3].	25.00	25.00	149.00	148.90	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.66	0.70	-5.58	2	36	2009-01-15 18:05:59	2003-06-02 11:26:44	6	1	6	0	0	36	0	431.60	79	99.96	CHANGED	MQ.SMSFLhGFGTLVLALSApTFDLQGLSCNTDSTPGLIDLEIRRLCHTPTENVlSCEVSYLNHTTISLPAVHTSCLKYHCKTYWGFFGSYSADRlINRYTGTV+GCLNNSAPEDPFECNWFYCCSAITsEICRCSIpNVTVAVQTFPPFMYCSFADCSTVSQQELESGpAhLSDGSTLTYsPY..pSEsVNpTLNGTILCNSSSKIlSFDEFRRSYSLANGSYQSsSINlTChNYTSSCRPRLhRRRRDTQQIEYLlHKLRPTLKDAWEDCEILQSLLLGVFGTGIASASQFLRGWLNHPsIIGYIVNGVGVVWQCHRVNlTFMsWNESTYYPPVDYNGRKYaLNDEGRLQTNTPEARPGLKRVMWFGRYFLGTVGSGVKP+RIRYNKTSHDYHLEEFEASLNMTPQhsIASGHETDPINHAYGTQADLLPYTRSSNhTSTDTGSGWVHIGLPSFAFLNPLGWLRDLLAWAAWLGGVLYLIsLCVSLPASFARRRRLGRWQE	.........MphSMS.LIuFGTLVLuLSApTaslQuLpCNTDSTPuLIDLEIRRLCHssTENVISCEVSYhNHTohpLsAsHsSChKYHCKTYWGFFGSYSsD+lIsRaTGssctClNsS.sEDPF.CNWaYCCSAIss-lCRCSIoNspVuVpoFPPFMYCSFADCSTVSpp-LpsGpAhLSDGShLhasPY.Lpp-VVNpThNGTIhCNuSSKlVSFDtFRRSYuLtNsSYpspSlNlTCsNhoSpCpsR.hRRRRDhpplpYLsHKLRPhLtDAWEDCEILQSLlLGsFGoGhuuASQFLRtWLNHsDIlGYIVNGlGVlWQCpRVNVoFhsWNESTYYPPVDhNGp+haLNDEuRLQTsoPEAhPGLKRVMWaGRhaLGTVsSG.+P+Rl+YN+oSHDYHL-EF-hShNhTPphulAoGHETsPINHAaGTQusLLPYsRSSNlTSTDTGSGWVHIGLPSFAFLNPhGWLRDlhuWAAWLGGlLYLlpLshSLPs.hARRRRLGRWpE.	0	0	0	0
+6037	PF06209	COBRA1		Cofactor of BRCA1 (COBRA1)	Moxon SJ	anon	Pfam-B_11228 (release 9.0)	Family	This family consists of several cofactor of BRCA1 (COBRA1) like proteins. It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfolding. BRCA1 mutations that enhance chromatin unfolding also increase its affinity for, and recruitment of, COBRA1. It is thought that that reorganisation of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions [1].	18.70	18.70	19.20	19.70	17.70	18.60	hmmbuild  -o /dev/null HMM SEED	475	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.56	0.70	-5.89	6	144	2009-01-15 18:05:59	2003-06-02 11:29:37	8	8	89	0	96	136	2	349.50	39	69.02	CHANGED	MPSlQPVVMsVhKHLPKVPEKKLKlVMuDKELY+sCAVEVKRQIWQDNQALFGDEVSPLLKQYIlEKEssLFSo-lSlLHsFFSPSPKTRRQGEVVQKLTpMIGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDlsEICoVDPCHKFTWCLDACIREKFVDuKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLAhSslRpLQELlup-uLPRDSsDLhLLLRhLuLGpGAWDMIDSQVFKEP+lD...sEllT+FLPhlMSlhVDDpsFNl-sKLPs-EKpsshh....PssLP-sFp...................................+FlpENRVACElGLYYsLHIsKQRNKNALhRLLPuLV-shsDhAFsDIFLHLLTupLsLLuDEFusEDFCoulFDsFLLTuhopKENVHRHsLRLLhHLHpKVsPs+lEsLhKuLEPspQpsEsl+ELYspLt-Klps...p+ssPssp.-ssuh-.sLtuVsssssh	.......................plpPVVMtlh+ph...c...ls-+hL......chlhtDc-LYpsssh-VKRQIWpsNpuLFuDEVuPLLppYIhE.......KEthL.hs....phs...p..........FF.t..s...PKsR.R..Q..up..l.l.+LspMlG.psl+LYDhlLQF....LR...TLFl+T+NlH....YCTLRAELLMuLHDh-lt....-IhshDPCHK.........FsWCLDACIR-+.VD.KRsRELQuFL-.sl.K+Gp.EpVLGDLSMlLsDPaAhNhLshSsl+.Lpc..Ll.s.p-.sLPR-s...Lh.LLLRhLuLG...uA..WpMI.-oQsF.KE.P+h-...hpllspFLPhhhuhh...l-D.h.hp.l.pt....+L..ss-c+tsh.h....ssshs.-....sh....................................................tal.....pppthup..luhaYhl+h......h......p.+.....sp.....s..l..+lL.shLsp..shs.c..hu.h.t.D..FL..H..lhs.Lh.....h..s-...ch...s....cp.hs.p.lh-tF.hhts.s.ppssp+H......hL+hlhhla.+..l....shhtt.l.ct.hpP.tt.....t........p..t.h.thh......................................h......................................................................................................................	0	47	56	76
+6038	PF06210	DUF1003		Protein of unknown function (DUF1003)	Moxon SJ	anon	Pfam-B_10814 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	24.60	24.60	27.40	24.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.48	0.72	-4.13	71	827	2009-01-15 18:05:59	2003-06-02 11:31:43	6	4	766	0	249	630	135	107.60	40	53.07	CHANGED	sGShtFllhasshlslWlslNshhhht..ht.................................FDPYP..FILLNLhLSh.AAhtAPlIhhuQNRQss+DRlpucpDhplNl+uEhElphLtcclstlttp.tphhtctpphpt	............hGohpFllhhslllssWlllNh..hshht....hp.................................FDPYP..FILLN...LhhSs.AAhtAPlIhhuQNRQ-cR.D..RlpsppDhcl....shpuct-hchLtcclstlthp.t-hhsc...hp.p.................................	0	81	162	212
+6039	PF06211	BAMBI		BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain	Moxon SJ	anon	Pfam-B_11792 (release 9.0)	Domain	This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling [1].	19.00	19.00	20.20	19.70	18.30	17.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.62	0.72	-4.05	4	68	2012-10-03 01:43:02	2003-06-02 12:43:19	7	2	50	0	36	72	0	100.80	68	38.57	CHANGED	puSLlSlWLQLELCAMAlLLTKGEIRCYCDAPHCVATGYMCKSELNACFT+lLDPQNoNSPLTHGClDSLhsos-sCpucsscs+otsosP...LECCHEDMCNYRGLHD	..............sshh.lWLQLELCAMAl.LL..TK.GE...IRCY.CDAsHCVATG...YMCKSELs.ACFSRLL..DP..Q.N....oNS.P...LT.HGCLDSl....AS....T..u.DlCpA+Q..ApNHS...G....o.shP.........oLECCHEDMCNYRGLHD......	0	7	11	20
+6040	PF06212	GRIM-19		GRIM-19 protein	Moxon SJ	anon	Pfam-B_10760 (release 9.0)	Family	This family consists of several eukaryotic gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) proteins. GRIM-19, was reported to encode a small protein primarily distributed in the nucleus and was able to promote cell death induced by IFN-ß and RA. A bovine homologue of GRIM-19 was co-purified with mitochondrial NADH:ubiquinone oxidoreductase (complex I) in bovine heart. Therefore, its exact cellular localisation and function are unclear. It has now been discovered that GRIM-19 is a specific interacting protein which negatively regulates Stat3 activity [1]. 	25.00	25.00	25.20	27.90	20.70	24.60	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.63	0.71	-4.44	11	296	2009-01-15 18:05:59	2003-06-02 13:27:30	7	4	250	0	189	281	4	119.70	37	86.33	CHANGED	suu.sK.QDhPPPGGYtslsa+RshPKpshSGauMFAshhGhhsaGhathhpts+Ec+R.pIE.hsARhAlhPlLpAE+DRcaL+.L++Nh-EEAclMKDVPGWKV....GEsVF+T...-+WVsPhhpEhYshpsh-	.................s.....h.QDhPPsGGY.tslpY+Rs.lP.p.+G.hs.........uhshhsshhuhhsaGaaplhps.s+cp.c.c......L.thEchtuRlsLhPlLQAEcDRc.hl.+phppshpcEtp.l..McsV...sWcs........................sp....pVapo...s+ah.Ph...........t.......................................	1	68	106	154
+6041	PF06213	CobT		Cobalamin biosynthesis protein CobT	Moxon SJ	anon	Pfam-B_10956 (release 9.0)	Family	This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid [1]. 	23.00	23.00	23.10	23.70	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.76	0.70	-5.27	6	469	2009-09-11 12:48:28	2003-06-02 13:36:36	7	7	445	0	122	386	1322	275.30	25	44.87	CHANGED	+soss.sssEPFKRAlssClRuIAGst-lEVuFus-RPuLsusR......ARLP-lP++sopp-hAlsRGLuDSMAL+hApHDP+lHu+htPpGt.sARAlF-AVEQARVEAIGApsMsGVAcNL...ouML-DKYpKushscl..ss+uDAPlEEALuLhVRE+LTGcssPpu...........AcplV-LWRsalEpKAutDlcpLuusl-DQpAFARlVRDMLuu.....................h-hAEEhGD-pspsDpE-s..D.-DsPpp-pp--pus-EppGs-s...u.uc-...u-uos--tEpu-hEuu-uos-DhsD-sDt	.......................................................................................................t.........pshKpAlstss+AlutchplcVsa.....ss....s....ps...t..h....supp.........hcL..P....p..h.s.cc.hs..tp.ch..s..hs..RGhuDuhAL+ltapDsplHtpht.Ppss....ARsl......a-AlEpsRlEulGucths.GsupNL...sshl..p...p..c.hpcs.p.hs..ph..pscs.s..usL.ttu...l..uhh...l...R....p+loGps.s.Pss.....................stpll-....L....hRph.....l..pp....puusp....Ls.sLt.......ps..l.p......DQt.......u...FA.......c.hs...+c..hlss....................................h..p.h..s.....p..c....u..p.c..p..p...s...-....p..pps......p...ppps.p....p.p.......p...p.pp.t...u..s.p..p.p...ps.ssp..........s.s.pp.........spss..p.p.....p..t....p..p...tt..pt..s..p.t.t.......................................................................................	1	33	78	95
+6042	PF06214	SLAM		Signaling lymphocytic activation molecule (SLAM) protein	Moxon SJ	anon	Pfam-B_11112 (release 9.0)	Family	This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones [1]. SLAM has also been recognised as a receptor for measles virus [2].	25.00	25.00	25.30	79.80	23.00	21.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.65	0.71	-4.19	4	58	2009-01-15 18:05:59	2003-06-02 13:48:11	6	1	36	6	14	52	0	122.10	64	38.47	CHANGED	MDPKGhLShphLLhLSLAhcLShGTGtulMsCPc.ILtpLGSslhLPLssE.pIsKSMNKSIHILVTMAcSPtsolcKKIVSLDLscGusPRaLpDGY+FaLENLoL+ILcSR+EsEGWYhhoLEENV	....................MDPKG.LLSLshlLFLSLAFchShGTGtshMNCPc.IltpLGSslLLPLTpE.tIsKSMNKSIHIlVTMAcS.tsSVc+KIVSLD.sEuGsPRYLcDtY+FaLENLoLtILESRKEcEGWYhMTLEcNl..	0	1	1	1
+6043	PF06215	ISAV_HA		Infectious salmon anaemia virus haemagglutinin	Moxon SJ	anon	Pfam-B_11275 (release 9.0)	Family	This family consists of several infectious salmon anaemia virus haemagglutinin proteins. Infectious salmon anaemia virus (ISAV), an orthomyxovirus-like virus, is an important fish pathogen in marine aquaculture [1].  	19.60	19.60	20.80	22.90	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.43	0.70	-6.16	3	464	2009-01-15 18:05:59	2003-06-02 13:54:06	6	2	3	0	0	388	0	318.40	88	99.80	CHANGED	MARFIILFLLLAPVYSRLCLRNYPDTTWIGDSRSDQSRVNPQSLDLVTEFKGVLQAKNGNGLLKQMSGRFPSDWYTPTTKYRILYLGTNDCTDGPTDMIIPTSMTLDNAARELYLGACRGDVRVTPTFVGAAIVGLVGRTDAlTGFSVKVLTFSSPTIVVVGLNGMSGIYKVCIAATSGNVGGVsLINGCGYFNTPLRFDNFQGQIYVSDTFEVRGTKNKCVLLRSSS-sPLCSHIMRNVELDEYVDTPNTGGVYPSDGFDSLHGSASVRTFLTDALTCPDIDWSRIDAASCEYDSCPKMVKDFDQTSLGNTDTLIMREVALHKEMIuKLQRNITDVKsRVDAIPP...NIFISMGVAGFGIALFLAGWKACIWIAAFMYKSRGRIPPSNLSVA	.......................RLCLRNaPDTTWlGDSRSDQSRVNPQSLDLVTEFKGVLQAKNGNGLLKQMSGRFPSDWYTPTTKYRILYL....GTNDCTDGPTDMIIPTSMTLDNAARELYLGACRGDVRVTPTFVGAAIVGLVGRTDAITGFSVKVLTFsSPTIVVVGLNGMSGIYKVCIAATSGNVG..G..VTLINGCGYF...NTPLRFDNFQGQIYVSDTFEVRGTKNKCVLLRSSSDTPLCSHIMRN.VELDEYVDTPNT.GGVYPSDGF.DS.LHGSAS...VRTF..LTDAL...TCPDIDWSRIDAASCEYDSCPKMVKDFDQTSLGNTDTLIMREVALHKEMISKLQRNITDVKh....R.V..-Ah.s....................NIF.....IS.MGVAGFGIALFLAGWKACIWIAAFMYKSRGR........................	0	0	0	0
+6044	PF06216	RTBV_P46		Rice tungro bacilliform virus P46 protein	Moxon SJ	anon	Pfam-B_11281 (release 9.0)	Family	This family consists of several Rice tungro bacilliform virus P46 proteins. The function of this family is unknown.	25.60	25.60	25.60	793.10	24.80	25.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.33	0.70	-5.62	2	12	2009-01-15 18:05:59	2003-06-02 13:59:52	6	1	2	0	0	13	0	388.60	77	100.00	CHANGED	hNhEhPYSIHhlsKN+VPIYcQGNLFHoEhouRLSHlSpGLlDHLFTF.SDNTERVRKLHllu-alY.hE.EhpoYp.Eh.pLp-QVSpLp.pspp.+tpltp.+-hlEGLREPlKKPIYTTQDKEtLRsFFCcERSMEYIYaHIKRLAppSYYSHLNKLQKDhE.hRGhYhSFLTNVKFLVLhEsGhWTs.sIEsp.hspS.L.loQccGEc.hpKGll.hN.E.EuG.Y.LostFluDLYAHGFIKQINFTsKlPEGlP.lItEKl.pYKFPGuNTlLIE+EIP+WsFs.MKRpTphRTplYIhpsaRsFYGaSPl+sYEPITPEEFGh-YYSWEphhE-Dct-VVY.ShsT+..KVs+E..aAWPpcDuDhMSCoTShtEEahHRht.A	hNhEhPYSIHhlsKN+VPIYcQGNLFHoEhouRLSHlSpGLlDHLFTF.SDNTERVRKLHllu-aLY.hE.EhpoYp.Eh.pLp-QVShLp+pspp.Rtpltp.K-hIEGLREPlKKPIYTTQDKEtLRsFFCcERSMEYIYaHIKRLAppSYYSHLNKLQKDhE.hRGhYhSFLTNVKFLVLhEsGhWTs.sIEop.hspS.L.loQccGEc.lpKGll.hN.E.EuG.Y.LostFluDLYAHGFIKQINFTsKlPEGlP.lItEKl.pYKFPGuNTlLIEREIP+WsFs.MKRpTphRTplYIhpsaRsFYGaSPl+sYEPITPEEFGh-YYSWEphh-EDEu-VVY.ShsT+I.KVsRE..aAWPpcDuDhMSCTTShE-EahHRh-...	0	0	0	0
+6045	PF06217	GAGA_bind	DUF1004; 	GAGA binding protein-like family	Moxon SJ, Bateman A	anon	Pfam-B_10604 (release 9.0)	Domain	This family includes gbp a protein from Soybean that binds to GAGA element dinucleotide repeat DNA [1]. It seems likely that the this domain mediates DNA binding. This putative domain contains several conserved cysteines and a histidine suggesting this may be a zinc-binding DNA interaction domain.	26.10	26.10	26.20	34.20	23.80	26.00	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.28	0.70	-4.45	10	153	2009-09-12 21:59:08	2003-06-02 14:01:58	7	3	38	0	65	172	2	273.70	39	97.75	CHANGED	MDscGh....Rphu.aac..............Ps..sshK.phuhQLMSols..-RDst............+-pNl.httppuuh.........tpRD.........................Mua..pDsWlsp.........+Dsthhsh..hpss............s..hthlsso+shcphQ...pp......pht-sshs.h.c.c...s.PlspssssspcstpspttppspsPKssKsc..KsK+tsssspcpsstss....c...............................sKss+Ksh-l.sINtVuhDhSslPsPlCSCTGsspQCYKWGsGGWQSACCTTslShYPLPhsTpRRGARluGRKMStGAFpKlLp+LAuEG.aDLSNPlDLKsHWAKHGTNKFVTIR	..........................................................MDsss.......Rphs.....ac...............................hh.......hplMu..hs..-Rsst..............pcts..h..h.ttptuh.........ttRD.............................hsh..R-shlsp............pcpthhsh..hpps........................................ht.h.....ts.pph.pt.p..................................ht.tsshs.......c..p.......t.s..l.p.p...ss..t.tp...s.t..s.K...p.p....ppsp.psK.s.psp....+sp+....sthspcpsp.ps....c...................................................s+ssh..Ks...-...l.sl..Nt....lshD..SshPsPVCSCTGsspQCY+WGsGGWQSACCTTslShYPLPhssp+RtARluGRKMStGAFpKlLp+LAuEG.aslusPlDLKsaWAKHGTN+alTI+............	0	8	43	52
+6046	PF06218	NPR2		Nitrogen permease regulator 2	Finn RD	anon	Pfam-B_11335 (release 9.0)	Family	This family of regulators are involved in post-translational control  of  nitrogen permease.	27.50	27.50	29.50	28.60	26.90	27.30	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.37	0.70	-5.78	16	363	2012-10-01 20:21:22	2003-06-02 14:04:55	6	7	244	0	279	366	2	293.80	27	83.34	CHANGED	GF.P.IpsIFYohFHPTpGoKlhaQsPsssl.................tsshhsFDol+sYlIPKPpLCNKLlTlp..hscY+llGYPVsI.psscYuRNuF.FNhsFVFsh-.scossYEssl+RLG+hhplLEEQophLSct-p..s.h....................................................................st.pIpsLlpplapDLNNYuEChIPlDsuNoIsIKLFPlhPsPss.lpsapVPIhslpLpsllD.sNWD.TMhKIlPaINGlNSlt+IucLADs-hpLs+pCIQHLlYYsCltllDIFQFSNIYAPTsplpsFlpss.shucECQsYVhssssp.............................st.t..s......................................................................plPopssLFpLYpSLsQGpTlK-Whtpphpt....l..ssIDlRRhIpFGll+ulIYRlapYPl....hsshs.......sptcchhph.tp......................hDclssctshs.tslpct..............pslhc	.......................................................h.....l.slhhs.F...................G...shl.hp.P.t.l......................................................................................................Fsshp.alIs+.thptp..h..lphp.............thpl..l..uhP..l.h..t..p....p.......Yt..RN.....t........h.F..NhshVht.p....p...............s.............h.....c......hlp+.huthhh..hE.p.sthlSp......t...........................................................................................................................................t......l..l....h..lhp-L.....N..t.........t....shl.l......sp....s..slplKlh........h.........sPs...h...p......pVPl....h..p...h..t.......th..t....pWD.Th.pllsaIsGhppltpIu...upsp.tLsh.s..lppLhaYtsl...........l...hshh.aush.....Yh..p.....h.....tp.h...h.t........s................h.p...tC.tal.....................................................................................................................................................................................................................................l..hthh.tth..p.............u......shtphh................lD.R+hl.FGl.cthlhph.pash......................................................................................................................................................................................	0	108	156	235
+6047	PF06219	DUF1005		Protein of unknown function (DUF1005)	Finn RD	anon	Pfam-B_11366 (release 9.0)	Family	Family of plant proteins with undetermined function.	20.40	20.40	32.60	24.80	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	460	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.60	0.70	-5.82	9	119	2009-01-15 18:05:59	2003-06-02 14:07:22	7	3	18	0	76	127	0	316.70	42	96.87	CHANGED	MDPCsFVRlhVGsLuL+h.......ssssspsssussc.ps...sChCcI+l+sFPhQhsslPLlshs-ups.......ssspolAAsFaLscu-lctlhp+spah..........usLclsVYs........GR+GssCGV..suut+LlG+hplslDLcuu...-uKsslhHNGWlslGppptpp.ts....sAELHLpV+sEPDPRFVFQFDGEPECSPQVlQlQGshKQPlFoCKFupcpsu..ps.p............t.W..ouhso-p..-ptu+ERKGWplTlHDLSGSPVAhASMlTPFVsSPGoDRVoRSNPGAWLILRPsGst...........oWcPWGRLEAWRERG....hpDoLGYRF-Ll.-G....usulshAEooIS.uc+GGcFsIDh.tt......ssh.s.ttphphuuhustuuus..tss.t....................GFVMSupVpGEGKsSKPhVcVuspHVTCsEDAAhFVALAAAVDLShDACRLFs++LR+ELpp	...................................MDPpsFlRl.lstLul+hP..............................t..t...s...sC..Cpl+l.th....P......p......s.hPhh...t.............ts.ussF.Lststlphh.t..s...................Lpl.las........G..u......t..t.....CGh......ttphlGhhpl.ls..ths....ucs..hhhasGWhsluptt............tsphpl.V+hEsDPRalFpFss-sthuP.lhQl.....p......G......s.....h+QPhFoCK...Fuhcp.s................................t.....tt.t+E.RKGW.lhlHDLSGSsVAhA.MsTPFVsSs.GsspVuRSNPGuWLIlRP.uss.............oWpPWGRLEsWREc.G...........D.slsh+hcLl...s.......sssl.hu-ssls.sppGGpFsIDh..............................................................t..GFVMustV.pGEu.+sS..+.Ph.VpluhtHVsChtDAAhFhALuAAlDLSh-AC+.Fpp+hR+chp.........................	0	10	47	64
+6048	PF06220	zf-U1	zf-U1; U1_C; 	U1 zinc finger	Moxon SJ	anon	Pfam-B_10606 (release 9.0)	Domain	This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly.  Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilise U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator [1]. This domain is probably a zinc-binding.  It is found in multiple copies in some members of the family.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.08	0.72	-4.39	11	661	2012-10-03 11:22:52	2003-06-02 14:07:45	7	17	296	1	456	687	10	36.70	41	15.13	CHANGED	MP+YYCDYCcsaLTHDo.SVRKtHsuG+pHtpslpcYY	.........+.aaCDYCcsalscDosSlRKpHpsGppHpcNVpca......	0	152	235	353
+6049	PF06221	zf-C2HC5	Zf-C2HC5; 	Putative zinc finger motif, C2HC5-type	Finn RD	anon	Pfam-B_11300 (release 9.0)	Domain	This zinc finger appears to be common in activating signal  cointegrator 1/thyroid receptor interacting protein 4.	24.30	24.30	25.20	25.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.67	0.72	-4.21	33	300	2009-01-15 18:05:59	2003-06-02 14:20:43	8	6	263	0	212	293	1	53.90	44	10.63	CHANGED	s+ptCsCtAppHsL......ssNCLsCGKIlCspEG.......sPCsFCG.sslhs.....sppppplhpt	.....s.p+.CsC.ApcH.L......hsNCLsCG+IlCppEG.......GPCh.FCG..s.lho.....pp-.p.h...p............	0	72	119	178
+6050	PF06222	Phage_TAC		Phage tail assembly chaperone	Finn RD	anon	Pfam-B_11379 (release 9.0)	Family	\N	25.00	25.00	39.10	39.10	22.10	19.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.56	0.71	-4.59	6	219	2009-01-15 18:05:59	2003-06-02 14:27:42	6	2	157	2	7	135	0	121.60	75	96.51	CHANGED	hspsLRslALsshuGaRHKT.VsVPEW-GspVsLREPSuEAWhhWpEll+...G.ucDD-s.loVsEKhpR.....NhpADVpLFlDVLhDpshQ...RVFS-DDppQVttlYGPVHuRLLppALEL....lsssE-A+K.	.......MtKDLKTLALARLSGFRHKT.VKVPEWtNVSVVLREPSAEAWYLWQEVLN.........G.DGE.DDDT.LSVVAKTRR.....NLEADVTLFCDVLCDTDLQ...RVFoPDDREQVLAVYGPVHARLLRQALEL....IADAESARKK...................................	0	0	1	5
+6051	PF06223	Phage_tail_T		Minor tail protein T	Finn RD	anon	Pfam-B_8084 (release 9.0)	Family	Minor tail protein T is located at the distal end and is involved in the assembly of the initiator complex for tail polymerisation [1].	25.00	25.00	26.20	25.00	24.10	23.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.37	0.72	-3.61	4	777	2009-01-15 18:05:59	2003-06-02 14:39:43	7	2	329	0	11	264	0	96.40	61	80.47	CHANGED	+LAREFRRPDWRpMLuEMSATELGEWu-aFsppSFSDsLLDAcFAoLKuLlsuLVoGsscsA.tDFSLLscpEuh.E+TD-ELMpLGEGIoGGVRYGPDSpPG	..........htRsDWRtMLAGMoSTEYADW++FYpTHYFpDs.LDMHFS...GLpYsVLSLFF.u..DPDM.HP....uDF..SLL..s...c.c..E....u.....p.E....h..E....D..-h..LMQKAAGLAGGVRF.GsDG.............	0	0	1	5
+6052	PF06224	HTH_42	DUF1006;	Winged helix DNA-binding domain	Finn RD, Bateman A, Eberhardt R	anon	Pfam-B_8424 (release 9.0)	Family	This family contains two copies of a winged helix domain.	24.00	24.00	24.00	24.40	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-12.14	0.70	-5.10	119	1653	2012-10-04 14:01:12	\N	7	6	1193	0	494	1415	196	321.90	24	76.36	CHANGED	lccLsslQhss....spstahsLauRls.sa...psstLpph.......hpc+plhchashcuo..ll.shc-h.hhphthtshhttt....t...............hphhstphpph.hstlhptl..tspuPloss-lttthttp...............tht....sspthhp.hlhhpG.lshsshp.uh.........phashs-ch...........................................................................................................................................ppps.....hctLlpchlpuhG.sAoss-lttaht..ls.t.....ps+tslt..thhtttcL.hthplc.....t.t....hashs...........s.....sthsssss.......h........plLssFDshlhs+pc..ppclh.s..hta+hcla.sss.sph.........shslLhsGpllGphchcsc..cps......usLplps...h...hscs.......................tts...slttphpchupa	..............................................................................................................lp+huhlQhss....s+usalsLauRls..sa........s.p..hL-cu..........htct..clhch.Wupcus..hh.Ptp.Dahh.hc.t..thhs.tphs......hhh...........................tshh.p.ptpt..htp...llptl...psc.G...P...........l..pus-hppthttt.....................th.h.php.........st+p.........h.....L-..tL........h..ts.........G.cl.........hsst.+.p..shp.........................+sYcL..sc+l...............h....Pp........tps..............................................................................pscu.........hthhlcphhcuhG..ss.......t.p....plssa..hp....Lphs.......shps.h..hp.....thht.t.t.pl..lsVp.l-.................t.ht....hahps..................................................c............tth.stt.ss.........s.......tlLuPFDsl.lhs+c+....tppLa.s.hpa+hEs.a.sssspp.............shslLhpGpllGph-h+hc..+pt..........shLplhs........hhhpt.....................htt...sltpthpphAta..................................................................................................	1	183	350	445
+6054	PF06226	DUF1007		Protein of unknown function (DUF1007)	Finn RD	anon	Pfam-B_8585 (release 9.0)	Family	Family of conserved bacterial proteins with unknown function.	21.00	21.00	22.00	21.90	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.44	0.70	-4.59	46	668	2009-01-15 18:05:59	2003-06-02 14:57:21	8	5	643	0	141	463	41	197.50	28	83.76	CHANGED	pthtlhhuslssh.........sAtAHPHsal-hpspllhssss..lsul+htWpFD-haSuhll...thcpspcuphsp..pcLpplupsshpsltphpYFThlh.ssGcpl+as.p.....................Ps........chthshcs....s........plhltFslsLsp.Phshp.tt......lslpsYDPoYalshsasp.c..sslplssts.tsCphplhpPsssss...........tpuLshspts......ssshGthFAp+lplpC	..................................tt...hhhshhshh.......uhAHPHsFlchpspllhcspt..lsulchpWphD-hhSuslLh........cs.tsut.ss.cthpcLutpl.h.ssl.hs..p+Y...FTplh....t..s...Gp..p..lKhp..p.....................Ps..............phthshcs.....p................................plllpFsl.sLsc.P.sls..sps......hshssaDPoYYlshpYsp...c.......sslshs..s......ttCphplhpPpsstt.h.........tht...toL.sptt.ts.......s.slGp.FApplplpC...............................................	0	29	75	108
+6055	PF06227	Poxvirus	Orthopox_N1;	dsDNA Poxvirus	Moxon SJ	anon	Pfam-B_10619 (release 9.0)	Family	This is a family of dsDNA viruses, with no RNA stage, Poxvirus proteins.	21.10	21.10	21.20	21.80	20.00	21.00	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.21	0.71	-4.71	37	475	2009-01-15 18:05:59	2003-06-02 15:01:29	7	1	40	23	1	377	0	156.50	20	92.13	CHANGED	M...............................................sp.s.............................................................hphsahhtsphs.tpcslpsllpcYhhaRsh....hhtppphG+lFpcLhpaDp.Ahpha...G.slp.....phhpshh..s.......hpshphhhphphshp.......hhpsptlIGlhuhluchhs.........thhslh.hhhphls.pphpp	.............................h......................................................................................................pashtcphs...p.sslpsllp-Ylhapsp.....t.p.shGpla+plhoacp.Ahcha...u.slp...............plhpph..................hpshs.al+hhhshs.......h.pspshIGlsuhlschhs.........phhpshhhhhph.l.s...h..t........................	0	0	0	1
+6056	PF06228	ChuX_HutX	DUF1008;	Haem utilisation ChuX/HutX	Moxon SJ, Bateman A, Eberhardt R	anon	Pfam-B_10620 (release 9.0)	Domain	This family is found within haem utilisation operons. It has a similar structure to that of Pfam:PF05171. Pfam:PF05171 usually occurs as a duplicated domain, but this domain occurs as a single domain and forms a dimer. The organisation of the dimer is very similar to that of the duplicated Pfam:PF05171 domains [1,2]. It binds haem via conserved histidines [2].	25.00	25.00	25.00	25.90	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.47	0.71	-4.80	38	458	2012-10-01 19:49:10	2003-06-02 15:03:01	8	6	445	9	79	1005	54	137.40	45	67.28	CHANGED	lApcLsloEh-VlpALPtchsshhsu..sphpplLpslspWGp.VTsIl+stsuIaEh+ushPpGc.hu+GYaNL......htppst..LcGHL+h-shstluhVs+PFh.Gpc...otSltFFsppGcslFKlYLGRDc.pRpLhspQlptFcsLt	..........................lAcphsso.h-VVc.sLP.pp..........h.s.h.s.sG........s+hsslh.-.s.l.s.c.WGs..VTTlV+os.ssIhEhpGt.lPp....G......p......h......u....+.......G....Ya...NL.........hu+cG....lpGHlKh-NsspIALlp+sFM..Gh-............otSltFFsppGp.shFKIaL.GR..D.-...+RpLhs-QVstF+sL........................................	0	14	41	60
+6057	PF06229	FRG1		FRG1-like family	Finn RD	anon	Pfam-B_8590 (release 9.0)	Family	The human FRG1 gene maps to human chromosome 4q35 and has been identified   as a candidate for facioscapulohumeral muscular dystrophy.  Currently, the function of FRG1 is unknown [1].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.13	0.71	-4.84	13	253	2012-10-02 19:42:32	2003-06-02 15:04:21	7	11	189	1	166	289	1	170.60	35	65.39	CHANGED	uSYlcAhssGhhThGtPHcs.spsPsPcElFsAs+l.u-p+luhKoGaGKYLuls..scGlloupu-AIuspEQaps...........lFpss+sAhhu..............ssssFlSssp.tp..h.upS+psupsEhlclRucssp.......shpsphclthpsRhcs+.pt.p.lKthQ....chpc+cL......RLsc--s+cLK+ARc-GshHEslLDhRsKhKsD+Y	...................................................lpshspG..shutPHp............................p.asAs+.l...u.sp...p...lu.hKo.u..a..G+YLu..hs..pp..G..l..lsupo-AlushEpaps.....................................lh.p....s....s..p..hAhhu.............................................ssssFlsssp..st....h.upuc...su....up....p-..hlclRusApc..................phppp..cl...p.s.+....t....ps..+tp..php.s..Kthp..........phpc+cL...................+l..scc-s..+hLK+A++-GphHEtLLDhRsK.hKtD+a........................................................	0	58	83	127
+6058	PF06230	DUF1009		Protein of unknown function (DUF1009)	Finn RD	anon	Pfam-B_8705 (release 9.0)	Family	Family of uncharacterised bacterial proteins.	25.00	25.00	57.40	31.60	21.60	24.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.07	0.70	-11.13	0.70	-4.97	83	491	2009-01-15 18:05:59	2003-06-02 15:08:55	6	4	486	0	172	434	1229	213.30	35	75.92	CHANGED	lGpllchL+ppGlscllhsGsl.pRPth.sslc......Dhpslpllsthh..uh.ptGDDuLL+ulhphhEp.pGhplluuc-lhscLLs.spGsLsptpPspppppDlthGhplspslGshDlGQusVVpsGtVlAlEuhEGTDshLtR..................supLst...........ttsuVLlKssKPsQDhRhDLPslGspTlcssscAGlsGlulEAGpslllDpptslptA-ctGlhlhu	..............Gcllchh+ppslscllhhGsV.pR.P.th..ps...l.p.......Dhtshplls.h....tl..spGDDsLLpullshlEp.pGhcVlusp-lhssLls..s.sGsloctpPssp-ppDIphGhchAptLu.tlDlGQusVVpsGtVlAlEu.hEGTDthlpR...................................sucLtp................puuVLVKhsKPtQDhRhDlPsIG.pTlcshtcuGhsGlAlEAG+slll-.p.pcslthAsctGlFlh........	0	74	121	142
+6059	PF06231	DUF1010		Protein of unknown function (DUF1010)	Finn RD	anon	Pfam-B_11467 (release 9.0)	Family	Family of plasmid encoded proteins with unknown function.	25.00	25.00	27.80	28.00	16.80	15.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.90	0.72	-3.98	8	110	2009-01-15 18:05:59	2003-06-02 15:14:07	6	3	46	0	6	54	0	88.70	68	92.27	CHANGED	MpAtoYSSAhPCS..................+GFpsFLASSACsASATSYaSCSAAPLpWPSAFSWAAPhhKAGRSlLAFGSN...sAlK.....P......TRlhRuAYLuR	.........................QTAFSFSuslQphhChFSG......LRLhuLRtFsVFLASSPCVASASSYtFCSAVPPRW+SsFSpLAPVAKh+LSVLASGSN...ISVK.....P......TRILRSAYLuR................................	0	0	4	5
+6060	PF06232	ATS3		Embryo-specific protein 3, (ATS3)	Finn RD	anon	Pfam-B_11504 (release 9.0)	Family	Family of plant seed-specific proteins.	20.90	20.90	21.00	21.10	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.82	0.71	-4.54	15	103	2012-10-02 11:40:54	2003-06-02 15:18:41	6	3	23	0	59	169	0	120.20	37	65.84	CHANGED	shptsppscptus...CsYsVpIcTSCsSPthTpDpISlsFGDAhGNpVYssRL............cDPsu..u.......sF-+CooDoFp.lpGsCht.pIChLYLhRsGsDGWhPEoVpl...Ys....ps.pPV..TFhaNphlPc.sVWYGaNhC	...........h.h.........tstp..CsYslhIpTSCsSst.hTpDpl.Slt.F.GDu..GNplass+L................csPss....t.......sFEcCusDoFp.l..pGsCh....tIC..alYL...h..R..s...G...p...D...GWhP-hVpl.....as.......tsp......p.ss......sF.as.p..lPp.s.sWYGashC............................................	0	4	43	53
+6061	PF06233	Usg		Usg-like family	Finn RD	anon	Pfam-B_11528 (release 9.0)	Family	Family of bacterial proteins, referred to as Usg. Usg is found in the same operon as trpF, trpB, and trpA and is expressed in a coupled transcription-translation system [1].	20.70	20.70	20.90	24.80	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.74	0.72	-4.12	27	204	2009-01-15 18:05:59	2003-06-02 15:31:43	7	1	184	0	72	150	47	81.30	60	86.78	CHANGED	h.LpGYGLTTAEIhY+hPDHPplLQoaVWQ-YDLAPcFPtLhcFL-FWpcElEGsLHSVRhsHp+LIpPuEaRsVsG.hpLH	.........h.QLtGYGLTTAcIhY+MPDHPpLLQoaVWQDYDLAP-FPtLpcFl-FWQcclEGPLHSVpasHp+LIusuEWRsVpGEhhLH.....	0	14	39	48
+6062	PF06234	TmoB		Toluene-4-monooxygenase system protein B (TmoB)	Moxon SJ, Iyer LM, Burroughs AM, Aravind L	anon	Pfam-B_10626 (release 9.0)	Family	This family consists of several Toluene-4-monooxygenase system protein B (TmoB) sequences. Pseudomonas mendocina KR1 metabolises toluene as a carbon source. The initial step of the pathway is hydroxylation of toluene to form p-cresol by a multicomponent toluene-4-monooxygenase (T4MO) system [1]. TmoB adopts a ubiquitin fold [2]. Although TmoB is a component of the T4MO system, its  precise role remains unclear.	25.00	25.00	43.20	43.00	21.50	20.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.77	0.72	-4.12	10	40	2012-10-03 10:59:06	2003-06-02 15:32:22	7	1	34	35	21	39	1	84.00	43	95.51	CHANGED	MALFPlhusFEtDFVlQLVuVDT-cTMDpVAttsAHH...........SVGRRVss...pPGpllRVR+pGssphhPRssplu-uGlpPhEslEllF-c	...MAlFPlhusFptDFVlpLVsVDocsTMDpVAstsAaH...........oVGRRVts...pPGtslRVR+pGst...phhPRshplA-uGlpPh-slElhap.s..	0	10	13	18
+6063	PF06235	NAD4L		NADH dehydrogenase subunit 4L (NAD4L)	Moxon SJ	anon	Pfam-B_10667 (release 9.0)	Family	This family consists of NADH dehydrogenase subunit 4L (NAD4L) proteins from the mitochondria of several parasitic flatworms.	22.20	22.20	22.40	28.20	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-9.98	0.72	-4.20	12	62	2009-01-15 18:05:59	2003-06-02 15:37:12	6	1	44	0	0	69	0	85.30	41	99.60	CHANGED	MlolhLlhssllllShhLshs+hhNhLIlLENaNVLlLLhCLlhoht-s.+hlFIshMsl.slEl.lhLlVlspshcpuShh.hluh	....MlslhLlh.ssllllShhLshtRhlNhLIlLEsFNVLlLLhsL.Lh.oht-s.+hlFlslMslhTlElslhLlVlsplhcpushh..ssh...	0	0	0	0
+6064	PF06236	MelC1		Tyrosinase co-factor MelC1	Moxon SJ	anon	Pfam-B_10673 (release 9.0)	Family	This family consists of several tyrosinase co-factor MELC1 proteins from a number of Streptomyces species. The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase MelC2 to facilitate the incorporation of copper ion and the secretion of tyrosinase indicating that MelC1 is a chaperone for the apotyrosinase MelC2 [1].	21.40	21.40	25.70	38.40	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.70	0.71	-4.14	9	48	2009-01-15 18:05:59	2003-06-02 15:43:53	6	1	34	23	15	62	1	126.10	37	87.36	CHANGED	lssAAslA.AuushuusspAssAsstuttst..ss.s.........sshssuFDEsY+GRRIpGtssuuGtt..............tauGuatVhlDGh.LHlM+sADGoWlSlVsHYcssPTPhAAARAAVDELp.GA+LhPhPss	..............................................h.hh............h.shhs..h.ssuusstustss.tsssst........sss.sssF.DEsY+GRRIpGsss....s...uustt.............ttuss..a....pVplDGR.LHVMRp....ADG....oWlSsVsHY-sa..sTP......LtAARAAVDELt..GApLtsh...s....	0	3	9	15
+6065	PF06237	DUF1011		Protein of unknown function (DUF1011)	Finn RD	anon	Pfam-B_11463 (release 9.0)	Family	Family of uncharacterised eukaryotic proteins.	25.00	25.00	35.70	29.30	24.00	22.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.29	0.72	-4.13	17	198	2009-01-15 18:05:59	2003-06-02 15:47:15	7	3	89	0	126	188	1	100.00	46	22.74	CHANGED	phsssphsalhhlluhlNuhoNGlLPSVQSYSCLPYGshAYHLussLSslANPlACFlAhFl.hRSlshlusLol.lush..FuuYlhshAuhSPsP.LhssshG	...........................h..tsphsaLhsLlAhsNALTNGVLPSVQSYSCLPYGphAYHLussLuuhANPLACFLAM.hl....sR..SLshLusLol.lGsh..huuYlMshAslSPCP.LhspssG.........................	0	35	46	86
+6066	PF06238	Borrelia_lipo_2	Borrelia_lipopr; 	Borrelia burgdorferi BBR25 lipoprotein	Moxon SJ	anon	Pfam-B_15000 (release 9.0)	Family	This family consists of a number of lipoproteins from the Lyme disease spirochete Borrelia burgdorferi [1].	25.00	25.00	26.80	26.60	22.40	21.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.62	0.71	-4.02	2	99	2009-09-11 01:58:06	2003-06-02 15:48:34	6	2	26	0	6	66	0	103.50	81	97.31	CHANGED	MQNNTIGLGLNLLSSLTNIAKTDTNIDHNYINTFSKVIDFFYKTYISTLKSMETAESTKIFEEIpDILKYNIEIIEAIShDKsK+IITSLKApRNKIMKEYIKhLKRuENA	.....................................MQNNTIGLGLNLLSSLTNIAKTDTNID..HNYINTFSKVIDFFYKTYISTLKSMETAESTKIFEEIQDILKYNIEIIEA....ISTDKSKRIITSLKApRNKIMKEYIKILKRGENA............................	0	4	4	4
+6067	PF06239	ECSIT		Evolutionarily conserved signalling intermediate in Toll pathway	Finn RD	anon	Pfam-B_9306 (release 9.0)	Family	Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1 [1].	24.30	24.30	24.30	35.60	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.64	0.70	-5.49	11	101	2009-01-15 18:05:59	2003-06-02 15:57:31	6	5	84	0	66	104	0	212.70	39	51.63	CHANGED	psptpssusppscps...hhsps.pstpp.hpt...lsshcslFcps..pp+sKssFlchlchFpc+s.V+RRGHVEFIYsAL++MpEaGVE+DLpVYptLL-VFPKthFhPpNlFQphFhHYPRQQpCuIclLEQMEsaGVhPstEschlLlplFG++SaPhpKahRMhYWhPKFKplNPaPlPpclPs....Dsl...-LApluLcRMss.DLpuclTVaQ.hs.spsu.s..c..csaIVuh	....................................p................................tp..p.tps...Ls.hcphFpps..tp+sKssFlpslchFtp+s.l++RGHV-FIYsAL++MtEaGVE+DLtVYptLLDVFP.K.thFh........PpNhhQphFh....HYP+QQpCulslLEQMEsa...G........VhPspEhchlLlplFGc+uaPhpKahRhhYWhP+FKN..lNPaPlP.cslPp....Dsl...-LAphuLc+hss.Dlpuclolap.hs.tsc-shs.....psaIVu........................	0	24	29	49
+6068	PF06240	COXG	CoxG; 	Carbon monoxide dehydrogenase subunit G (CoxG)	Finn RD	anon	Pfam-B_9339 (release 9.0)	Family	The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.47	0.71	-4.51	15	764	2012-10-02 19:24:03	2003-06-02 16:18:11	8	6	531	3	309	754	612	139.90	26	60.58	CHANGED	Gphclsss.ppVachLsDP-plssClPGspSlpttu.sEacsplplplGsl+usa....suclphsplcsssphh.lpscGpGttAGhuhssshhhhspssst.oclsasscsclGGhlAplGu+llcussc+llschhpslusclu	...............................p.plssshppVWssL...sD.sch.ltsClP....G.s.p.p......l....p..t....t.....u...ts...p.....a.p..u....s.....lp.l.cl..G..P...l..pupa................pGpl..pls..c...h...c....ss..p....p..hs...lsuc.G.pu..u..t.u.u.......h..st....u.....s....s.hs..h..h..h........p..s....s........s.....s...T.......plsass...csp....l.u........G.+.l...AplG..s..+.l..l.sssu....c.+lhspFhsshstth.t......................................................................	0	93	183	250
+6069	PF06241	DUF1012		Protein of unknown function (DUF1012)	Finn RD	anon	Pfam-B_9320 (release 9.0)	Family	Family of uncharacterised proteins found in both eukaryotes and bacteria.	32.90	32.90	32.90	33.00	32.20	32.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.31	0.71	-4.73	2	84	2009-09-11 06:58:58	2003-06-02 16:22:51	7	5	32	0	50	86	2	169.20	58	22.88	CHANGED	ARAIIILPTKGDRYEVDTDAFLSVLALpPIQKMESIPTIVEVSSsNhYDLLKSISGLKVEPVENsTSKLFVQCSRQKDLIKIYRHLLNYSKNVFNLCSFPNLsGhKYRQLRLGFQEVVVCGlLRDGKVNFHPNDsEELMETDKLLFIAPL...KKphLYTDMKhENhTVsp..DTRKQVaEcK+SRLpKIIhRPpKSLSKGSDShKGP	.........ARAIIVLAp.ctNADQSDARALRsVLSLsGVKEGL.+GHlVVEhSDlDNEsLVKLVGG-lVET..VVAHDVIGRLMIQCARQPGLAQIWEDILGF-NsEFYlKRWPpLDGhpFcDVLlSFPDAlPCGl...K...p...s.G.KIllNP-DsYV.Lp.....E......GDElLVIAE................................................................................................................DDDo.......................................................	0	6	32	41
+6070	PF06242	DUF1013		Protein of unknown function (DUF1013)	Finn RD	anon	Pfam-B_9390 (release 9.0)	Family	Family of uncharacterised proteins found in Proteobacteria.	20.60	20.60	20.70	106.40	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.65	0.71	-4.19	35	348	2009-01-15 18:05:59	2003-06-02 16:32:47	6	1	348	0	115	277	1365	141.00	57	63.33	CHANGED	LEVpuIADG-VApGIpGhDPlssGQLTp-EI-+scpDPsh+L+lt.sp..shhscpK....KGsRYTPVS+RQDRPDAIhWll+NHPElsDuQIsKLlGTTKsTIpuIR-RoHWNusNIcPpDPVsLGLCoQh-LDttVp+..Aucct	..LEV+uIADGEsApGIKGhDPlssGQLTpEEIp+uEcDPsa+LKLp.sp...stl.s..c.pK.+..KGPRYTPlS+RQDRPsAIhWLl+NHPELpDuQIu+LlGTTKsTIppIRsRTHWNsuNlpPhDPVsLGLCSQlDLDhtVp+Aucpp.....	0	32	69	82
+6071	PF06243	PaaB		Phenylacetic acid degradation B	Finn RD	anon	Pfam-B_9426 (release 9.0)	Family	Phenylacetic acid degradation protein B (PaaB) is thought to be part of  a multicomponent oxygenase involved in  phenylacetyl-CoA hydroxylation [1].	20.70	20.70	21.00	21.90	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.12	0.72	-3.85	43	641	2009-01-15 18:05:59	2003-06-02 16:40:32	6	3	601	2	212	450	72	92.20	56	92.12	CHANGED	ppWPlaEVFlRucpGLsHpHsGSLHAsDschALptARDlYTRRpEGlSIWVVtuspI................................................................................sASsPs-..............+s.hFcPupDKsYRHsoaY.....clP..........................-s......lp+h	.......................WPLaEVFVRuKpGLsH...+...HVGSLHAuDscMALcsARDlYTRRs.EGsS.IWVVtuupI.............................................................................sAS..s..P-E+uthF-PApsKlYRHPTFY......plP...DtltH...................................	0	56	132	180
+6072	PF06244	DUF1014		Protein of unknown function (DUF1014)	Moxon SJ, Coggill PC	anon	Pfam-B_11009 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	21.30	21.30	22.60	22.50	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.66	0.71	-3.90	14	313	2012-10-02 14:16:02	2003-06-02 16:51:30	7	4	282	0	212	300	4	148.50	32	66.20	CHANGED	T+AQItcphpc-pptpct.pptppt.......-h.hEc..shNhph.-pspsE.............................................ARol--AIusLSlsc.....shD+HPE+RhKAAapAaEEspLPcLKpEpPshRLSQhKQlLhKEWpKSP-NPhNQ+	........................................................................................................................t............t...t..t...t.pttp..t.ttth.....t..hp...c....ht...s.....p....t.....t....tt..-...............................................................................................Aps.lDsAls....sL.olssp.............thDRHPERRh.KAAYpAFEEpcLPclKp..E..p..P..uLRh.....sQhKphlhKcapKSP-NPhNQ........	0	75	120	176
+6073	PF06245	DUF1015		Protein of unknown function (DUF1015)	Finn RD	anon	Pfam-B_9451 (release 9.0)	Family	Family of proteins with unknown function found in archaea and bacteria.	19.70	19.70	19.80	20.20	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.30	0.70	-5.97	97	830	2009-01-15 18:05:59	2003-06-02 16:53:50	6	6	778	0	268	769	822	388.30	33	97.45	CHANGED	plpPF+ulRsstchstpluu.....PYD.VlsspEtcphhptsPaohl+lphPchshs.ths..pp..YppAtcphpcahppGlLhpDppPshYlYcpphs.s.........ps...ppGllussslc-Yp.....pshI++HEtThts+cpDRlphlcsssANsuPlFlhYpc..spplspllpphh.p....ppPhh-assp.sGlpHplWhlsDtphlpplpphF.tthp................slYIA..DGHHRhsoAhphtpcpcppss.ths.upE.saNahhshL..hscspLpIhshpRlV+sL.suhs.cpalpplpph.Fplpphs.....................................................t.htssppppauhY.lss.paYtLph+p....t...t.p..ss.........lppLDVslLpchlLpslLGI..ps.Rs-p+IsaltGhcslh.....h.ctVcsGp.hplAFhlhPsslcplhsluDsGplMPsKSTaFtPKLtSG..Lhl+pl	...................................................................l+PF+ulR.Pst..p..h.st.......plA.u.....PYD.VlsscEs.cphhp.ssshShl+l.psEhshs..shs.hsp..............Yp+AscshppahpcGhlhpDpcsshYlYc.phs.u................+sQpGlVssssl--Yt.............ssh..I++HEhTht-+EtDRhchlcsssAphsPlFlsYcs.....ppt....l...p.pllppht.p..........ppPhY-Fss.....DGhpH.phWhls-p..phlpplsptF.t.p.h.s...................slYIA...DGHHRsAoAsp....lttc+cpp......t............s....t....ht..sp...............c....taN.............aFLull..hscspLpIhsYNRVV+..cL.....pshs.cpF.L.pp.lppt..F..p.lcphs.........................................................p.hp..P.s..p..hpsauhY.lss..p.aY..pLss+t...t..th.sp.........cs............................................lpsLDVsl.Lpsh..lLs.lLuI.....pD.Rs..-..pRI-FluGl+ultt............ctVssup.hplAFslaPsshcplh.slADsGplMPPKSTaFEPKLcSGLhl+ph..............................................	1	143	226	256
+6074	PF06246	Isy1		Isy1-like splicing family	Finn RD	anon	Pfam-B_9462 (release 9.0)	Family	Isy1 protein is important in the optimisation of splicing [1].	20.20	20.20	20.30	21.10	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.73	0.70	-4.98	31	342	2009-01-15 18:05:59	2003-06-02 17:00:10	7	8	291	1	245	340	3	234.50	38	85.85	CHANGED	MARNsEKApSMLsRapptppsphthhct....+RPphsscsssLspAE+WRppll+EIo+KVscIQssuLu-apIRDLNDEINKLh+EKppWE.+Ip.pLGGPsYp+hus.p..hhDscGp..clsG....scGY+YFGtAK-LPGV+ELFE.ppppt.........tps++sRtc........hh+plcssYY.Ga.tDE......-DshLlthEtphEcphhpp.h.p......................t..thtttp.pphht.h.t..t.................................................................th.lPopp-lpp.llc+++pcLLp......Kh	............................................MARNsEKA.ohLsR.apptptt-tth.................hc.........RRPhhsocspslspsE+WRt.pll+.EIo+KVspIQs.............suL......u.-apIRDLNDEINKLhREKtpWEhpIc.pLGGPsY....t+.hus+...hhD...p.-G+...ElPG..............s+GY+YFGtAK-LPGV+ELFEpps............................ccs+tc...............h.h+pl.Ds.pYY.GY..hD-.......-DuhLl.h.Et.phEcphhtph..h................................................................................tttp...........p...h.....t..tt.......................................................................................................hhth.lPo.p-lpp.llc+++.cLlpc.........................................................................................................................................	2	89	138	204
+6075	PF06247	Plasmod_Pvs28		Plasmodium ookinete surface protein Pvs28	Moxon SJ	anon	Pfam-B_11346 (release 9.0)	Family	This family consists of several ookinete surface protein (Pvs28) from several species of Plasmodium. Pvs25 and Pvs28 are expressed on the surface of ookinetes. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals [1].	26.00	26.00	26.20	27.30	25.00	25.90	hmmbuild  --amino -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.65	0.71	-12.07	0.71	-4.73	11	164	2009-01-15 18:05:59	2003-06-02 17:02:55	6	2	22	5	12	166	0	197.10	58	88.67	CHANGED	KVTVDTlCKNGhLIQMSNHaECKCspGaVLhsENTCEcpV.cCcc.-slsKsCG-YuhChspus.sp.psh+CsChsGYhlspslChPscCpshsCG.sGKCIlDssNssps.sCSCsIGKl....pNsKCTtsGcTcCsLKC.KtsEcCKhsstaYcClscsuustsusutsp................................................sss.......SlhsGhSlhsILsLhllal...hl	...KVTs-T.CKNGalVQMSNHFECKCN-GaVhh.sENTCEEKp.-Csp.pslNKsCG-YuhCssst.ssppcsh+CGCI.GYTlhp-..lCsPs+Cps...l.CG.pGKCILDssNsNso.hCSCsIGps...--sKKCsKsGcTcCoLKC.KsNEcCKpspsaYKClsKsuustsuuutss..................................................s.us........SlhNG.uVhsIL.h...hah..s.............................................	0	3	5	10
+6076	PF06248	Zw10		Centromere/kinetochore Zw10	Finn RD	anon	Pfam-B_9476 (release 9.0)	Family	Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis [1,2]. These proteins bind to the centromere/kinetochore [2].	19.30	19.30	19.60	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	593	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.86	0.70	-6.36	12	279	2012-10-03 17:31:52	2003-06-02 17:10:26	8	11	205	0	185	344	1	435.20	19	61.30	CHANGED	h......................tpsstlph-.Dhptpls+lpp+lcchpscVpshIsccYs..-FhsshpusppllppsctLsc-l.DlLps.lps-lhtsLpsuss-hsphpppLccsthslpllppL..chcsth.....cphspALpsKsYltsAchLpch+shLctlps.cspp.............LchhpuLphEhplptppLl.pLsccap+Ll.aphsop.......pshhpspLpLsptpsp.........LssVl.Ahsh.GpLppplcthsphLlc.llcPLIspPshhsss-pppc.s.....lhLsappp.......pophc+sssppVap+lhhllcsLpphhhslssppp..........lhpllGchlhcclschlIccCLshuIP..ssuschpp.appllppsp-FEptLK-htals.s-s.osL.cYAcslssaFssK+CpcVlssARpLMpp-hashVh..........lsPp........................................................................t..t.cstppluptohshPsChlScSsp.cLMcLhhpsLpEs.ssusttsuspLhholcslhpLahssVPphHcc.LtplPQhuAlaHNNCMYluHaLhshuaphph.....h...hsoFsDlVsshRphGscsFhsQhphQ+upLh-tLsutp.Fpph.ssccphos	.................................................................................h..t.....phptpl................p.ht....p.....ph........ph...........hpp...s.......pth...htp....spthtpcl...........th..h.pt....h....t...p................................h.tt..plpss...scht.lpp..plp..p.p.hhph...lp.p....l.....tphpphl............p.ph..ptshtp...t.phhtuh..p......hlpphp.thl..p......................p......................thhp.lp.c.....ht..pppl..tLtp.apphl.h.p.......................phphtt.t.t.tt...............lp.phl.uht.h.t.l..t....th..tp...htp.lhp.hlpP.hl........s...h..............t....................l...ph..............................tt.t..s.ttlhtpl...h.lhph.lpp.l.................................................h.p.huphhh.......p..h.phllpphL..ulP...ps.pphtp.ap.pl.lp.pstp.Fppt.Ltp..........hthh............t.................p...........tL.paspph..hahp+hp.phl.ts.Rplh..t......t.............................................................................................................................................................................................................................................................................................................................................t...................................................................h...............hh.ha...............t.....sh....h..Nsh.ah...h...............................................................................................h......hp.....t...h..............h........................................................................................................................................................................................	0	64	100	147
+6077	PF06249	EutQ		Ethanolamine utilisation protein EutQ	Moxon SJ	anon	Pfam-B_11530 (release 9.0)	Family	The eut operon of Salmonella typhimurium encodes proteins involved in the cobalamin-dependent degradation of ethanolamine. The role of EutQ in this process is unclear [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.69	0.71	-4.67	4	785	2012-10-10 13:59:34	2003-06-02 17:11:56	7	4	744	3	116	676	368	139.80	48	71.45	CHANGED	hoKELlEpLl+pVlcEKhu.tpst.p.s.h+phD.SGIhulKL.sspsscpsRhDTGNP+DVVhTpDLhTL-ESsRLGAGlMEMK-TTFsWTLsYDElDYVIEG+L-llIDGRplsAcAG-lIhIPKGSpIcFSVss.A+FlYVsYPAsWpS	................................................................................................hscpLltpLhcK.VhpEK.uhp.........t..p...s.h.pphs...GhuulKll-usol+hs.RFDs.up.Pc...sVuhT.DL..VT..t.-..-...u...s.s..MuAG.FM.ph.....-...s..u...h..F..P..W..T..L..s..Y......D...E..IDh..VL..E..G..-..L...cV..c..c.-...G.....c..T...h.l..A+..AGDVhFIPKGS..o..I..cF..u..T..s..u..s..s.+..FlY.VsaPANWQS........................	0	41	76	99
+6078	PF06250	DUF1016		Protein of unknown function (DUF1016)	Finn RD	anon	Pfam-B_9571 (release 9.0)	Family	Family of uncharacterised proteins found in viruses, archaea and bacteria.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.79	0.70	-5.46	7	1895	2012-10-11 20:44:44	2003-06-02 17:15:21	6	10	943	0	343	1531	191	214.50	28	90.17	CHANGED	lht-I+phI-puRpcshpuVNupLshhYWpIG+hIlEtpptGp.+AtYGtpllppLu+cLsp-as..+GFospNL+pMRpFhhhasc..hhtsLhtpLoW.....oahplL.plcst.pRsFYhcpshcptWSsRpLptQIsohhYERphlS+c.pcshpp....h.stpphpsc.sl+DPYlL-FLuLt-p..a.E+-LEpullp+LppFLLELGsGFuFVuRQ+RlplDsccFaIDLLFYphtL+Chlhl-LKlGcFphp.hGQMphYLpah-ch.+pPs-sPsIGlILCssKscs.lcYsLptpppslhsuEYKh.LsscEpLtpcL.pt	...............................................................................h...h.ttp.thh.thN..hh.hha..lGp.l.t........pttaGtthlttlu..tlt.th....pG..hs.psl..hh.ah..a.......................................................h.......h......p............t....h.....................t...........p...................l..........s...........h....................p.h......h...t....h.t.p.....tt...a.Y...s.htttWo.t..L...htt..hat+.....s...........................................................s....hh+s.h.h-hht...h.....t........h...Etphcttlhtph.pahhEhGtsF.a.spp..h..h.t.t......p.hhhDh........lhaph.hpthlh.h-lK.t.ht.t.huphthYhthhpt........t.-.t.slGlllCtttt....hph.h.......t.hhhupa.........h.............t.h.......t..........................................................................	0	95	224	306
+6079	PF06251	Caps_synth_GfcC	DUF1017;	Capsule biosynthesis GfcC	Finn RD, Sammut SJ, Bateman A, Eberhardt R	anon	Pfam-B_9574 (release 9.0)	Family	Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation [1].  This family plays a role in group 4 capsule biosynthesis [2].  These proteins have a beta-grasp fold [3]. Two beta-grasp domains, D2 and D3, are arranged in tandem. There is a C-terminal amphipathic helix which packs against D3. A helical hairpin insert in D2 binds to D3 and constrains its position, a conserved arginine residue at the end of this hairpin is essential for structural integrity [4].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.48	0.70	-5.19	17	1054	2012-10-03 10:59:06	2003-06-02 17:25:22	6	19	714	4	140	613	338	216.40	40	55.92	CHANGED	tsshsVplhtssp...phplsassshRLtplVtps.............pshshaW.uAsLh-..tpupscpppQplLtpLuphup.....pssschtushppLtpQLptlplstRlhhsLD.DhlRlscptNP.L.pGpYhLhlsP+sspVolhGhV..p.......psGshsapsttsspsYLpptsLlssA-pS.salIpPDGpspptPlAYWNcpah-hsPGuhlaVsF..t.osh.pphs..sLNppIlpLLpNRhsh	..........................................................................................................................h.stssVpla..Gp...ppsholsssEplhpLVsQP...................hhsp...WWP.uA.l.ls..-p......A......p......u..t.......Ah..p.......pp.....Q....tlh.s.p...LA.p..htA...................-uss..D..s..A..A......s.I.......ps......l.....Rp.....Q.....lps..Lc....l......T......G...R.......h..l..p.L.D.P....D..hVR..V...s..E....p....u....N.P.PL...p.............GsYTLals..spP.s.TV...TLhGhl..S.........psGp.P.ap.sGR.sVssYL....p....s....p.s...h.L.u.G.AD.+s.........h.s.aVlhP-Gc.o..p..p........A..P..V...A..h....W...N..K...R..H..l..E.....P...PGShlalGh..usplh....stp.s..sLNspIlpsLTQRlP.t............................................	0	33	78	110
+6080	PF06252	DUF1018		Protein of unknown function (DUF1018)	Moxon SJ	anon	Pfam-B_11125 (release 9.0)	Family	This family consists of several bacterial and phage proteins of unknown function.	27.00	27.00	28.90	27.70	26.40	26.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.61	0.71	-3.59	54	451	2009-01-15 18:05:59	2003-06-02 17:38:09	7	3	363	0	82	413	9	116.80	26	75.27	CHANGED	hDD-sYRshLtp.....hsG+pSspchs.spLppVlcthcp.pG..F............hppstt...................p.ts...t..hs.......pss.hcKIcAlWhphtptsshtp.sct.ALssal+Rhh...........tlsslpaL..p.sppsppllpuLKp...Wpp.Rt	......................................hDD-sYRshLtp.....h.s.GKs..Ss+chshspLp...pVlpthcp..pG..F...................p....pttt...................p.ss.............t.shs...........pts.hp...KIpAlWtphstth...........s..p.....uLs....tal++hh..............sls.p.....lpaL..s..sppsppllpsLKp...hppR................................................................	0	30	58	73
+6081	PF06253	MTTB		Trimethylamine methyltransferase (MTTB)	Moxon SJ	anon	Pfam-B_11132 (release 9.0)	Family	This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.	25.00	25.00	25.80	25.70	19.40	17.60	hmmbuild  -o /dev/null HMM SEED	505	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.52	0.70	-6.74	8	451	2009-09-10 22:07:33	2003-06-02 17:43:21	6	2	119	2	177	465	1554	462.60	30	97.03	CHANGED	tRpuGRtuR+A.Russuspphsh.plspshsshplLs--plEtIHcsuh+lLEElGI-shs-.pAl-lacpAGAcVt.cstRVRh-+ulltEhlposPusFTlHARNPp+slplGGpslsFussuGuPpVpDl-+GR.R.GsLtDapNhs+LApthsslHhhGsslCEPhDlsss.pRHL-slauplphSDKsFhsospu+tRApDulEMhtIstGt..-phcssP.sshoIINsNSPhhaDtsMsculhshActGQsllloPFsLuGAMuPVTlAGALsQpsAEALAGlALsQLlRPGAPVlYGsFsSsVDM+SGAPuFGTPEsupushsuGQLARRYsLPaRTuuu.suSphsDAQAAYEoshuhauAlLuGuNllhHuAGWLEGGLssSYEKhllDh-hLtthhcalpulslsE-sLuhDAItEV...GPGGHFhGspHThc+YpTAFYpPhluDapsFEpWsEpGupDttpRAsclWKchLA-YEtPhlDsAlcEsLc....-alA+R+schG	...........................h...............................................hphLsc-plptI...apsuhclLE-lGlphhss...pAlclh+puG.A.p...V............ps......p..pV...+hscsllcchl.t.pAPp..pFTh.puRss...c..c.slplG..G..p..p.hhau..ss.hus.........P.hl.hD.h.c.s....s+...R........uoh....pDhtshs+Ls.phhsslchs.u.s.ss.stP..pD..ls.....ss..ppcl.s..h..hhs..p..l.phocKs........hh.....ss......s......s..s.....pps......pc.....s.......l..-M........sp.....lhhGt.......-...hc..pps.....hh...h.s.h.hs.ss..SPLpaspshhpslhthuctsQssllss.hshuGAhuPsolAGslsQs.AEsLAGlshsQllpPGsPsla.Gsasosh.DM.+..o.G.usshGoPE.shhshusuQl.A.+.h.a.sLP.h+suuu.hssuKhsDsQAuaEsshohhhuhhu.GsNhlhHuuGhL-uhlssShEKhlhDs-hlshhp..+hh.cG..l..ph..s.........-..c..s..l..uhD.sI.c.c.V.......G..P.s.GHaLuptHT...ppaps.s.a.ahP.tlh.Dpp..shcp...Wp.tt.G.t.hshhp+AptthcchLss....a...p......P...l....DsslcctLp....thl.......................................................................	0	84	140	150
+6082	PF06254	DUF1019		Protein of unknown function (DUF1019)	Finn RD	anon	Pfam-B_9681 (release 9.0)	Family	Family of uncharacterised proteins found in Proteobacteria.	19.60	19.60	21.50	20.70	19.20	18.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.17	0.72	-3.82	12	911	2009-01-15 18:05:59	2003-06-02 17:45:42	6	1	343	4	26	400	0	86.30	43	56.64	CHANGED	phs-........slspNRQKlF.RWLcs..DopttR-plptLhPAIhusL...PhEh+sRlps.sshh.hlspht.KEhs-Appulhh......hh+-ls-tIssh	.............................hPc..ALupNpQKIF.RWlcp..DT.DthEKhpALlPAI.cAh..............P.h..Lhs+...hpstpShha........+Els-s+-pl...........l+-sD-hlts................................................................................	0	2	7	12
+6083	PF06255	DUF1020		Protein of unknown function (DUF1020)	Moxon SJ	anon	Pfam-B_11136 (release 9.0)	Family	This family consists of several MafB proteins from Neisseria meningitidis and Neisseria gonorrhoeae. The function of this family is unknown.	25.00	25.00	46.30	41.60	24.20	24.10	hmmbuild  --amino -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.92	0.70	-5.23	15	288	2009-01-15 18:05:59	2003-06-02 17:46:46	8	13	49	0	16	255	0	227.60	44	62.34	CHANGED	DuFIRDshQRQHYEPGGKYHLFGssRGSVu-RoGpIslhpspoHplGNLLI...QQAuIcGsIGYpsRFSGHGHEVHSPFDNHAS+SsSDEuGuVD-GFTVYRLHW-GaEHHPADGYDGPQGGsYPtPsGARDIYSYalKGTApsIKLNhTDsRShuQRlhDcasNAGSsFosRADEAsK+haEasPcLDRhGNuMEslNGlAsGAlNPFluAGEulGlGDIlpGsspulshAA.......M+sLGsLSsEuKhAsIssLuDsAthcKsutsAl+cWAspNPNAApTlEAllNVh.AAhslhth.................K+spLsssAhPhGKuAVSssFutu....YpsP.tuRs	............DshlppshptpHaEPsGKYHLFGs.RGpltpRshtlthhp..s..huslh....ppsshpG.lGY.s+FSsHGaE.HuPFDpHsucSsSc.tGssstG..FolYplphpG.EhHPtDuYDGPpGusYP.PtGARD.YoY.lpGsupph+hN...........ssptshtpRh.cp.tshuu.h.ptss-u.+hhhc.ssphsh.uNtM-.lpGls.tGAhNPhlsuhphlGhGshh.uh..s.s.ss.......hpslu.LssEsphAhhs.Lts.A.h.cpshpuscpWhptpPNhstTspsshslh.AA........................KhspLs.sths......sKsss....................h............................................	0	5	5	5
+6084	PF06256	Nucleo_LEF-12		Nucleopolyhedrovirus LEF-12 protein	Moxon SJ	anon	Pfam-B_11198 (release 9.0)	Family	This family consists of several Nucleopolyhedrovirus late expression factor-12 (LEF-12) proteins. The function of this family is unknown [1,2].	25.00	25.00	141.00	121.10	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.15	0.71	-4.51	12	26	2009-09-11 05:10:50	2003-06-02 17:51:17	6	1	25	0	0	23	0	176.70	38	87.59	CHANGED	spcpFppRLsYVssIsshMpcTLchMshpGthocsDAsTLClADDTAAWlCGRscsss.FsSFRl+hut..F.ppsspsLp+FhFEESLtQ+h.....tshs+YTYMNYsl.hcs.lAIKLsVhht..chcsD........sLsYFVshtsupspshs.........................csssshphpLs.......hEchlEEhlspussp	........pppFspRLpaVssIsshh+csl-hMsppsthopsDAsoLClADDTAAWlCGRlssss.FVSFRl+hst..F..c+sspsLc+FtFEESLtQph.....pshs+YsYMNYol..pshlAlKLlVahc..shpss........sLsYFlpststpspppsp.h.+....................cpss.hphsLsh......hEphlE-shsptlV........................	0	0	0	0
+6085	PF06257	DUF1021		Protein of unknown function (DUF1021)	Moxon SJ	anon	Pfam-B_11556 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	26.30	30.20	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.51	0.72	-4.29	44	1201	2009-01-15 18:05:59	2003-06-03 09:26:38	6	1	1190	2	152	402	3	76.60	46	88.55	CHANGED	hspsLssIKpsl-s+lGc+lpl+AssGRKKhhc+pGlLccTYPulFVVc..LDpp......psshcRVSYSYoDlLTcsVplpa	...............sppltcIKppl-sHlGpplhlpApsGRK+p..hpRpGlLtETYPSlFlV-..L-ps......psshp+VSYoYoDlLTEslplpa....	0	56	98	125
+6086	PF06258	Mito_fiss_Elm1	DUF1022;	Mitochondrial fission ELM1	Moxon SJ, Eberhardt R	anon	Pfam-B_10595 (release 9.0)	Family	In plants, this family is involved in mitochondrial fission. It binds to dynamin-related proteins and plays a role in their relocation from the cytosol to mitochondrial fission sites [1]. Its function in bacteria is unknown.	21.80	21.80	21.90	23.40	21.20	20.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.77	0.70	-5.48	31	342	2012-10-03 16:42:30	2003-06-03 09:28:41	6	2	271	0	131	321	1802	296.30	25	87.47	CHANGED	sGpcsQshGLucALuh................................shphpplthpp...................................h.th..h.ssshs...shPcLlIuuG+pTthhshhl++htsst.hsVtlhcP+hs.hppFDLllsPpHD......................pl.sssNV.....lhohGulptlssttltpstt.....ht...+splslLlGG.soppaphssp.htplssplpslhppts.h.plhlTsSRRTPssstshLpphht.....hstl.la..stss....sNPahshLuhADslhVTsDSsSMlsEAsuoG.sPVhlhsls..s.pps.+hschhspLhppGhl+sasuh..hpt..ht.htPLs-s.....s+sApplhpchth	......................................................................................................sGppsQshuLsptLsh..................................................................................................hp..h..hplphpt............................................................thh........s.hh......sht...t....h...th.htt..hpt.....PslllusGpps.t.hshhl+....+....hh..ts.hhslplh.....c......P.phs....hstFDhllsPpHD.............................................th.tssNVlhhhGulptlssttlttst.th.....t...h.....h.................psh.l.slllGG.ssp..p.apaspp.htplhptl.pplhpsps..hslhlosSRRTPtps.tshlpptht........t..s..pl.la......stss.....N.P.ah.u.hLuhA-tlllTsDSlSMloEAsuoG.pPVhlh..shs.....t...pps...+hpp.hhppLhpp.thhp..h.s.t...h.t.........h.s..lp-stchAt.lht....t....................................................................	0	45	94	109
+6087	PF06259	Abhydrolase_8	DUF1023;	Alpha/beta hydrolase	Finn RD, Bateman A	anon	Pfam-B_9720 (release 9.0)	Family	Members of this family are predicted to have an alpha/beta hydrolase fold. They contain a predicted Ser-His-Asp catalytic triad, in which the serine is likely to act as a nucleophile [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.30	0.71	-4.78	6	556	2012-10-03 11:45:05	2003-06-03 09:31:10	7	6	239	0	146	545	20	174.30	31	36.72	CHANGED	DPtspshAApssGDl-sA-+VSVsVPGlsoss...ppohsshhttstthttcshstpptAu.ss..ssAsIAWhGYpsP........ussuhsssTsspAcsGAscLsthlcsLpAso..sstcloLFsHSYGSlVsuLAhcs.....ss.VsDlVlhGSPGhcAsssApLGs-.u+sasMpus-DaIppl.Pplus	.....................................................................................tpshAslulG.ss.D.s.A.cc.VuVh.VPGssosl...................pssh..s..s...h.p.p.s.ts...h..t..........t....p............h.....hp..tp.t..s.u....ss...........ssAsIAWhGYcs.P.......................ss.s.h.hp..s.s.ss.s.h.A.....csG.AspL....sp.Fhpu...L................p.....u............s.......p.....ss.......s...s..c.............lTllGHSYG.S.l.lsu.h.A.hpp.................s.h.t.ss-.l.V.h..h..G...S.P..G..h..............s....................s...s........s..........s......u.......p......L.sh..s...............u.+s..as.hp.u..s..s.D.lt.......s..............................................	0	60	119	141
+6088	PF06260	DUF1024		Protein of unknown function (DUF1024)	Moxon SJ	anon	Pfam-B_11584 (release 9.0)	Family	This family consists of several hypothetical Staphylococcus aureus and Staphylococcus aureus phage phi proteins. The function of this family is unknown.	21.20	21.20	22.30	22.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.91	0.72	-3.83	3	370	2009-09-11 11:00:23	2003-06-03 09:32:37	7	1	210	0	4	184	9	79.50	82	96.81	CHANGED	MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGlsNAhQ-ulKEsItLDEAlGIMsuQVlYEYEEEQENE	.......MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGlsNAhQculKEsItLDEAVGIMsGQVVYKYEEEQEN-................................	0	3	3	4
+6089	PF06261	LktC		Actinobacillus actinomycetemcomitans leukotoxin activator LktC	Moxon SJ	anon	Pfam-B_11552 (release 9.0)	Family	This family consists of several Actinobacillus actinomycetemcomitans leukotoxin activator (LktC) proteins. Actinobacillus actinomycetemcomitans is a Gram-negative bacterium that has been implicated in the etiology of several forms of periodontitis, especially localised juvenile periodontitis. LktC along with LktB and LktD are thought to be required for activation and localisation of the leukotoxin [1].  	25.00	25.00	27.10	140.60	22.50	20.80	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.99	0.71	-4.50	2	18	2009-01-15 18:05:59	2003-06-03 09:42:17	6	1	11	0	0	10	0	139.60	91	99.45	CHANGED	MSuTEYAPFYLRFIQFPsNEV.LhEYWpLVQN.VpKlp+ITVhhAQIlGhhuEKsIWKYQuTFNDGhLEsEVAK.-VSLTLRNSALLVASAIVIHFKSNFTNLLILSQITQYppahPh.KKSKY.PLYhSCLLRRRLTEFKITLLPLPWG	MSGTEYAPFYLRFIQFPSNEVLLYEYWKLVQNFVQKVSKITVRLAQIVGILGEKTIWKYQSTFNDGMLEGEsAKQEVSLTLRNSALLVASAIVIHFKSNFTNLLILSQITQYCRHRPKPKKSKYFPLYLSCLLRRRLTEFKITLLPLPWG......	0	0	0	0
+6090	PF06262	DUF1025		Possibl zinc metallo-peptidase	Finn RD	anon	Pfam-B_9726 (release 9.0)	Family	This is possibly a family of bacterial zinc metallo-peptidases. Although they carry the HExxHxxGxxD motif, they are missing a final methionine which would class them as Met-zincins.	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.09	0.72	-4.20	78	911	2009-10-19 15:30:34	2003-06-03 09:47:56	6	14	671	2	290	712	69	87.30	28	61.27	CHANGED	hssVslhV-Dh..Pstt.hsphtht...pLLGLYcGlsLo-+ush...uthP..DpIhLaRcPlLchh......s-cs-..Ls-.VpcsllHEIuHHFGlSD--lct..lsh	..................................................tl.h.ltt...s.....................................lhG.ap.Ghslsp...ps........ssthP..s+IslYRcPl.phs.........ssc--..Ls-..hVpcsllHEluHaaG...ls--clctht.........	0	93	203	253
+6093	PF06265	DUF1027		Protein of unknown function (DUF1027)	Moxon SJ	anon	Pfam-B_11526 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	81.90	81.60	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.93	0.72	-4.11	32	1012	2009-01-15 18:05:59	2003-06-03 10:12:50	6	1	1008	1	97	433	0	85.50	54	52.69	CHANGED	lplsshpacllcNh+-uF-tEthtpRaS-lLsKYDYIVGDWGh-QLRL+GFYcDsspps.hDp+IosLpDYLhEYCNFGCAYFVLc	.....lplsshtacLlcNa+-uFc.EpFtpRaS-l.LsKYDYIVGDWGh-QLRL+GFYcDsspcs...hsp+ISsLpDYLhEYCNFGCAYFVLc.........	0	20	49	73
+6094	PF06266	HrpF		HrpF protein	Moxon SJ	anon	Pfam-B_11646 (release 9.0)	Family	The species Pseudomonas syringae encompasses plant pathogens with differing host specificities and corresponding pathovar designations. P. syringae requires the Hrp (type III protein secretion) system, encoded by a 25-kb cluster of hrp and hrc genes, in order to elicit the hypersensitive response (HR) in nonhosts or to be pathogenic in hosts. The exact function of HrpF is unknown but the protein is needed for pathogenicity [1].	21.70	21.70	22.60	23.50	21.30	20.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.39	0.72	-3.85	7	64	2009-01-15 18:05:59	2003-06-03 10:41:15	7	1	59	0	13	36	0	73.40	46	98.66	CHANGED	M.ShsuLQRRLDsshpcApsplD-AshpuuEu.ho.sD.aAFhEAuhphusAShAssQpLpsKHGLsKAlIstIp	.....MhShpuLQppLDoshsRAposlDDhsLsuupG.hot-DhpAFsEASpphusAS.AAsQphpstHtlsKslI-uhp..	0	0	3	8
+6095	PF06267	DUF1028		Family of unknown function (DUF1028)	Finn RD, Bateman A	anon	Pfam-B_9747 (release 9.0)	Family	Family of bacterial and archaeal proteins with unknown function. Some members are associated with a C-terminal peptidoglycan binding domain. So perhaps this could be an enzyme involved in peptidoglycan metabolism.	25.20	25.20	40.70	32.70	22.70	22.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.13	0.71	-4.87	78	406	2009-01-15 18:05:59	2003-06-03 10:49:56	7	10	357	2	175	408	353	190.90	39	75.84	CHANGED	TFSIlA+sspTGphGlAluSs.lAV....Guh.lsas+AGVGAVATQu.hssPth.GspuLchLppG.hsAppslpplhssD..sttchRQlsllDspG....psAsaTGspshsh...tuphsGps..hustGNhLssspVlpAMspuFpsss..................st...Lu-RLlsALcAGpsAGGDtR....u..hpSAALhVss....ptsa..........shlDLRVDhpsc..P...ls-L	...................TFSIlA+..ss.......c...oG.......p..hGlAluSp.hAV.....GAh.sPascAGVGAVATQs.h...ssPsh..Gs...puL..chLc.p......G.....hssppuLctllssD.............sttphRQlsllDspG...............psAsaTGpcs...hs..h.............tuth..sG..c....s.................hsstGNhLuutpVlpAMspuFpsss.....................ut....Lu-RLlsALpA...G.sAG.G-tp......s...hpSAA..LhVls...ptsa...........sh.lDLRVD.pps...PlscL.................	0	57	107	144
+6096	PF06268	Fascin		Fascin domain	Moxon SJ, Bateman A, Finn RD	anon	Pfam-B_11660 (release 9.0)	Domain	This family consists of several eukaryotic fascin or singed proteins.  The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture [1].\	      Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerisation and binding to microfilaments only at pH values below seven [1].  Members of this family are histidine rich, typically contain the repeated motif of HHXH [3].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.38	0.72	-3.97	23	817	2012-10-02 19:42:32	2003-06-03 12:37:00	8	24	166	30	411	843	24	107.60	21	63.95	CHANGED	ssta.ssc+hsscLsAstts.psh...........plapLphpss...shs..L+.opsG+YLshtscGpltspsp....tssstFplchp....u+hshhptspG+YLs..ussupLpu.pusssupsELasl	............................................................................................thh.sspp..t.h.p.lsustt..p.tph...........ph.apLp..hssp..................shth...l.....+..o.p..sG+..Ylsh.ts.cG.s..ltssss.........ssssh...F.p.lphp...........sph...s..h..h..ptssG+YLs...hss.sG...pLt.u.pupssu..tsEhath.........................	0	103	156	257
+6097	PF06269	DUF1029		Protein of unknown function (DUF1029)	Moxon SJ	anon	Pfam-B_11672 (release 9.0)	Family	This family consists of several short Chordopoxvirus proteins of unknown function.	25.00	25.00	63.20	62.70	17.20	16.10	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.75	0.72	-3.96	11	43	2009-01-15 18:05:59	2003-06-03 12:41:20	7	1	37	0	0	21	0	53.00	63	99.48	CHANGED	MITNYEPlILlsIlshullsNhplSpKsKlDIIFhlpollFhWFlFHFlHSVh	MISNYEPLlLLsIhCssLLhNFslSSKTKIDIIFslQoIVFhWFIFHFVHSsI..........	0	0	0	0
+6098	PF06270	DUF1030		Protein of unknown function (DUF1030)	Moxon SJ	anon	Pfam-B_11673 (release 9.0)	Family	This family consists of several short Circovirus proteins of unknown function.	25.00	25.00	128.20	127.60	16.20	14.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.85	0.72	-4.43	2	10	2009-09-11 20:47:49	2003-06-03 12:43:03	6	1	6	0	0	7	0	53.00	95	88.33	CHANGED	MVFIIHLGFKWGVFKIKFSELYIHGYTDIVVLVVaTVFERSAEAYhVaISpuL	MVFIIHLGFKWGVFKIKFSELYIHGYTDIVVLVVFTVFERSAEAYVVHISRGL	0	0	0	0
+6099	PF06271	RDD		RDD family	Bateman A	anon	Pfam-B_1111 (release 9.0)	Family	This family of proteins contain three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD family.  This region contains two predicted transmembrane regions. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. The molecular function of this region is unknown. However this region may be involved in transport of an as yet unknown set of ligands (Bateman A pers. obs.).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.86	0.71	-4.28	114	4557	2009-09-14 12:06:15	2003-06-03 12:48:13	7	44	2499	0	1260	3598	868	135.70	17	61.94	CHANGED	hushhpR.hhAhll.Dhllhhhlhhlhshhhhh.............................................hhhhhhhhhhhhl.........hhhhahhhhhth..tGpT.lGKhlhsl+lls..............psupth....sht..pshlRthh....................................................h.hhhhhhhhlshlhhhh......spc+..p..slHDhlu.s	.............................................................sshhpR.hhAhll.Dhhl..lh.h.l.h.h.h.h...hhhhhh..................................................................................................................h.h.h.h.h.h..h..h.h.h...h.hl............h.h.h.hah..h..h..hhth......tGpTlG+thhtl+lls............................tsu.p.p.l.......shh.......p.sl...l.Rthh.........................................................h.hh..h.h..h..h.h..h..l..sh..lhshh...........s.tc+.....p.shtDhhu....................................................................	0	414	844	1088
+6101	PF06273	eIF-4B	Plant_eIF4B; 	Plant specific eukaryotic initiation factor 4B	Moxon SJ	anon	Pfam-B_11679 (release 9.0)	Family	This family consists of several plant specific eukaryotic initiation factor 4B proteins.	28.00	28.00	28.40	28.20	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-13.00	0.70	-5.74	6	148	2009-01-15 18:05:59	2003-06-03 12:55:18	6	5	33	0	89	145	2	231.40	23	78.73	CHANGED	MS...KPWGGl...GAWAh-AERAE-EptppA......sA.......tAsAsotsFPSL+EAAsupu....p+KhKphoLSEFphssYsts.........potGLTpp-hh.LPTGPRQRSt-Ehp.uRLGGGFpSY...t.........................GGGRpsYuGGFDsDpRs.tsRsSDhspsS..................................RAD-lDDWu+sKK..PhPSh-ptcpu.RYsu.......................hGGGGGG............uht.......Ghts.stusDsDpWuRuc..ss.........hscsG..................cERPRLlLpP.Kt-ssuo.s.Pss..tpS+PuPFGAARPRE-lLAEKGLDW+Kh-o-IEtK.....TSRPoSupSSRPuSApSspstSsh.p....Gs-sss+sRPKVNPFGDAKPREVlLpE+GKDWRKIDhELEH...RcV-RP...ETEEEK.LKEEIppL+tcLccppuh..p.ttstp-.......ptls-hIpphE+pL-hLshELDsKVRF........G.+.hpRPGSGAuRsusaspps.scupsh-sp..ht.M-RPRSRGssDshs+PsD-.RpuFQGS+..ERG	......................................................................................................................................................................................................................................................................................t....................................pu-..tpW...+.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	19	56	75
+6103	PF06275	DUF1031		Protein of unknown function (DUF1031)	Moxon SJ	anon	Pfam-B_11618 (release 9.0)	Family	This family consists of several Lactococcus lactis bacteriophage and Lactococcus lactis proteins of unknown function.	19.90	19.90	19.90	119.10	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.66	0.72	-3.94	2	29	2009-01-15 18:05:59	2003-06-03 13:04:35	6	1	24	0	3	21	0	79.00	63	97.37	CHANGED	Msthph.shhKL.sLAhpsphs.satp.SVhIosRTKtsHELsplYhDIpshaNpuKpMpWspLaphh.KpLTcsh.l..	.MlKTNFlTLKKLaGLA+NNNasss+K-LSVKISGRTKaNHELSQLYLDICNKYNHSKQMKWp-LYKIL.cELTcshtI-..	1	1	1	1
+6104	PF06276	FhuF		Ferric iron reductase FhuF-like transporter	Moxon SJ, Bateman A	anon	Pfam-B_11690 (release 9.0)	Family	This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.\	     FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B [1].  This family also includes the IucA and IucC proteins.	20.80	20.80	20.90	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.83	0.71	-4.28	156	3190	2009-01-15 18:05:59	2003-06-03 13:08:12	7	11	1404	17	525	1984	20	162.10	18	31.46	CHANGED	ptWhppYhphhlsPllthh..hpaGlsh.......psHhpNhllhhpst.GhPsp..hhh+Dhtsthhh.st.......h.............t.tt..hh.....p.hhpphhhslhhsplt.lhstLsp........stlscpthWphltphlpthhpphsphttt............hhtthhhtsslstcs.......................Rhtstsptts	....................................................................................tWhppYhphhl..Pllthh...hpaGluL..........-sHh.QNhllth.......cp.........G.....hssp....hhl.+Dhpst.hh.hhpt......................................................................t.ps...hhht....p.hhpphhtsl.....l.spLttlltslsp.......t..ssls...EphlWphltphlpphhsp.hsphssp....................hthhc.h.h.t..p.hshct....................th.......t....................................................................	0	119	287	418
+6105	PF06277	EutA		Ethanolamine utilisation protein EutA	Moxon SJ	anon	Pfam-B_11716 (release 9.0)	Family	This family consists of several bacterial EutA ethanolamine utilisation proteins. The EutA protein is thought to protect the lyase (EutBC) from inhibition by CNB12 [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	473	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.58	0.70	-5.89	19	699	2012-10-02 23:34:14	2003-06-03 13:13:58	6	2	662	0	49	1989	1083	442.30	60	97.76	CHANGED	cp.lhSVGIDIGToTTQLlFS+LplcNhAushsVPRlpIl-KEllY+SslhFTPLhspstIDsctl+pllcppYcpAGIs.psIcTGAVIITGETARKENAppllpsLSuhAGDFVVATAGPcLESIIAG+GuGAtphSc-+pssVlNlDIGGGToNlAlFcpGclhsTuCLclGGRLI+hDs.stclsYIuPthcpllcchulp..lplGspsshpplpplsctMsphLhpslshp.hoshhphLhhsc............slss..stplcs.....loFSGGVA-tlYpptpt....-.FcaGDlGhlLGpAl+psshhp..phplhpssETIRATVlGAGsHTsplSGSTIhhs.p-.hLPl+NlPVl+hst--ct.s..pslspulppplshFcl..csppptlAlAhsGptsssatplpslApulhpuhpphhppphPLllVl-pDhuKVLGpsLhshLshptsllCIDulplpsGDYIDIGpPlhsGpVlPVllKTLlFs	..................................................................................................................................+.pLLSVGIDIGTTTTQVIFS+..LELs.N......cAuVSpVPRaEhIcR-IsapSPVaF..T...PlccQutlcpscLKsLIL..c..QYp.uAGI.sP.EuVDSGA.lIITGESAKp..+..NARssVhALSpSLGDFV..VASAG.P.H.L...ES.V.I.A..G.+GA.G..AQ.o...L..S..E..Q..R..h..C.R.VLNIDIGGGTuNYALFD.AGKlSGTACLNVGG.....R.....L..........LE.....TD......u....QGR....V.......V...Y.....A.....H..p..P..G..Q...h...I....l.....D..E.....s...F...G...u.......G....T...-....u....+....u....L...o....u.u....Q..L......s......Q..V........s....R..R.....M......A.....p.....L........IV.....EVIsG...s.......L...S....PL....AQ...u.L...M..Q..T.s............LLPA....sls...P.El.....ITL.S.GGVGECYRpQPA.......DPFCFuDIGPLLATALH-HPR..LR......EMNVQFPAQTVRATVIGAGAHTL..SLSGSTIWLE..sV.pLPLRNLPVslPh--.......................pDLssAWpQALh...Q.LDL..-PcTDsYVLALPAoL.PVRYAAlLTVIsALlcFVA.Ra..PNP+.PLLVVAtQDFGKALGMLLRPQL.......Q.L.PLAVIDEVhVRuGDYIDIGTPLFGGSVVPVTVKSLAFP..........................................................................................................................................................................	1	24	36	43
+6106	PF06278	DUF1032		Protein of unknown function (DUF1032)	Moxon SJ	anon	Pfam-B_11729 (release 9.0)	Family	This family consists of several conserved eukaryotic proteins of unknown function.	23.70	23.70	25.10	24.10	22.30	23.30	hmmbuild  -o /dev/null HMM SEED	565	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.85	0.70	-6.03	4	230	2009-09-11 13:33:15	2003-06-03 13:15:43	6	10	116	0	163	219	1	251.70	20	56.13	CHANGED	MNFhEAALLIQGSAClYSKKVEYLYSLVYQALDFISsK++s+QhousspDGspcsss..APppsEp-FhuLDDlssscs....NVDLKcDphssslhIlPLhP.ALVsP-EhEKpssPLhSppGElLASRKDFRhNTChPpPpGsFhL-.lGhs.hpslp.h........httsQ+-.scuEppPMEl..S.susPs.s.phSpE...tsEussssGGh....-E-A-sGAE........thtlEssE.hppcpushpsRtYhLR-R.ptssEssupLpETPDPWpsLDPF-Sh.EsKPF+KGKsYoVPsGl-E.hsupKRKRKGssKLQDFtpWa.sAah-ts-ucRuRRKGPTFADMEVLYWKHlKEpLcs.RphpRRcusp.....paLsctEptlhPlEE-RlEDslE....s.GsADDa.-sE.....-hsE.stus.spEsA..Dl-s.sh.spLpYEELV+RNV-LFlssS..........QKasQETtLSpRlR-WEDsIpPhLQEQEpHssFDIHpYGDplsupaSplspWpsFApLVAGp.saEVCR.MLASLQLANDYTVEloQpPGL-suVDTMuLRLLTpQRAHpRFpTYsAPShsQ.	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................lttWp..h...L.......p..p..apht..sp.hht.h.........................................................................h......................................hsp.h.s.L.h....................................................................................................................................................................................................	0	66	97	134
+6107	PF06279	DUF1033		Protein of unknown function (DUF1033)	Moxon SJ	anon	Pfam-B_11732 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins. Many of the sequences in this family are annotated as putative DNA binding proteins but the function of this family is unknown.	25.00	25.00	62.50	62.30	23.20	21.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.84	0.71	-4.29	16	683	2009-01-15 18:05:59	2003-06-03 13:18:02	6	1	679	0	40	200	0	112.80	45	97.96	CHANGED	MYpVlchhGDaEPWWFh-sWp-DIlppppF-sap-AhpaYpphW.chcppaspapo+pshhsAFWNpsDpcWCE-C-EsLQpY+SlhLLpspcsh.s..phh.thtppst....t..Cplpt	..MapVlcMaGDaEPWWFh-sWpEDIVppppF-sa.DAhKaYpphW.chcppas.Ypo+pshhssFWsspDp+WCE-C-E.LQpY+SLhLLpsp.pVl.s.ppht.hhphpst.....t...Cph..h...............	0	6	15	30
+6108	PF06280	DUF1034		Fn3-like domain (DUF1034)	Yeats C, Moxon SJ	anon	ADDA_1269	Domain	This family consists of several domains of unknown function which are present in several bacterial and plant peptidases. This domain is found in conjunction with Pfam:PF00082, Pfam:PF02225 and is often found with Pfam:PF00746. This domain has a structure similar to an Fn3 domain [1].	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.68	0.71	-3.66	47	863	2012-10-03 16:25:20	2003-06-03 13:19:24	7	76	562	3	234	844	9	117.40	23	8.11	CHANGED	lsLpph.ssp..hsFslsl+NhuspshoYplsst.....shTch.....s..ppGhhhtstts.t....................shshsssslTVsAsuotslslslss.sthtt....................pshalEGalphpsscss..............plolPYh	.....................................................lsLtpl.scp...hpaslpl+N.hus...p..s..hTaplssp........shT-t.............s...pps.p.h..stp..t.hs..................................shshs.tsslTlsAsuo.tslssslsssp.s.hsp.......................sh.alE..G.FlpFpuspst..............slolPah......................................................	0	57	142	195
+6109	PF06281	DUF1035		Protein of unknown function (DUF1035)	Moxon SJ	anon	Pfam-B_11733 (release 9.0)	Family	This family consists of several Sulfolobus and Sulfolobus virus proteins of unknown function.	25.00	25.00	46.10	43.70	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.67	0.72	-4.19	8	29	2009-09-11 12:40:51	2003-06-03 13:21:24	7	1	15	0	1	33	0	63.20	65	61.94	CHANGED	VLFsPIlSpVN.LTTstoaTTh...SGTl..TposhlsNPQYVGSSNATlVsLVPlFYLLVLIIVPAVluY+lYKpE	VLhssIhSpVNsLT...........SGTs..........PphsGo.NATLlsLVPLFYlLVLIIVPAVlAYKIYK..c..	0	0	0	1
+6110	PF06282	DUF1036		Protein of unknown function (DUF1036)	Moxon SJ	anon	Pfam-B_11760 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.10	21.10	21.50	21.40	20.70	18.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.72	0.71	-3.77	23	269	2009-01-15 18:05:59	2003-06-03 13:24:19	6	4	205	0	101	224	15	113.00	37	65.94	CHANGED	sApA-aclCNpTsshVslAlGY+sss..uWsoEGWWplssssCpsl.lpGsLssRaYYlYApDss....tts....pWsGchphCsp-.scFsI..tGsp-ChsRGapcsGFtElDTup.ppsWTlpLT-	...........................ApADh+lCNsTpshVulAlGY..+s.ts......uWsTEGWWplss.usCcTl...lcGs.L.s..uRYYYlYAcDsp.............tuu........pWsGp..s.phClt....-...pcF.pI...pGsp...D...ChuRGap+sGFtEhDTuc.ptsWhlpLo............................................	0	25	55	70
+6111	PF06283	ThuA	DUF1037; 	Trehalose utilisation	Moxon SJ	anon	Pfam-B_11803 (release 9.0)	Family	This family consists of several bacterial ThuA like proteins. ThuA appears to be involved in utilisation of trehalose [1]. The thuA and thuB genes form part of the trehalose/sucrose transport operon thuEFGKAB, which is located on the pSymB megaplasmid. The thuA and thuB genes are induced in vitro by trehalose but not by sucrose and the extent of its induction depends on the concentration of trehalose available in the medium [2].	31.90	31.90	32.10	31.90	30.90	31.80	hmmbuild  -o /dev/null --hand HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.44	0.70	-4.63	91	1197	2012-10-03 00:28:14	2003-06-03 13:27:10	6	87	601	10	469	1171	683	219.50	23	52.37	CHANGED	+lllascs.tthpp....h..h..............shtssltphhpt....stthpssshp-..tpshsc.....pp..........LsphDlllhhsst...t..............sc.phtpslpcaVt.sG.tGllslHsuthsth............p..........apc.lhG................................................................................................................................................uphphHs...........stpphplh..lhsssHPlspGl...s.pt.....................aph.p-EhYshph.hPpss....pVLhoh..............................tsGcsashuashph..............................GtGRlFYpshGH......p..........sh.sa.pssshpphlhsulpWAs	....................................................................................hlhtt....tt..pt....p...h..............shtttltp.hhp...............ttsh..p..s..s..s..t...p..s....p..s...hsp............................pp..........L.s..p.hDl.llhhsst........tpt.........l.........................ss..pth....pt.....l....tph....lp.sG.tGllslH.u.s....hs..sh............................p..................app..lhG..................................................................................................................................................u..t.h....pt....Hs...............shpphplh........lh...s..s.....s..HPlsp..Gl.......pp.................................aph..p-E.hYs..hph...sPp...t..............hpl..Lhshp..................................................tsup.s..aP.....huWsh.ph..............................GtGRlFYsshGH.........................p................st..sa.p.ssshpphlhsulpWu................................................................	0	213	376	431
+6112	PF06284	Cytomega_UL84	Cytomegalo_UL84; 	Cytomegalovirus UL84 protein	Moxon SJ	anon	Pfam-B_11948 (release 9.0)	Family	This family consists of several Cytomegalovirus UL84 proteins. The open reading frame UL84 of human cytomegalovirus encodes a multifunctional regulatory protein which is required for viral DNA replication and binds with high affinity to the immediate-early transactivator IE2-p86 [1].	25.00	25.00	74.40	32.90	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	530	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.70	0.70	-6.09	4	46	2012-10-03 01:18:03	2003-06-03 13:30:03	6	2	15	0	0	42	0	419.40	53	97.45	CHANGED	MPRAD.TLRNtsR.uRsRKus.............................................................................h.sD-TILTLTDpHclKpPLs++GTY+LIQLHlDhpPp-LQHPFQILLSsPLQL.....................................Es.ss+pDscERGlLCsVuNtDSDIhPshSLFPApsG.CpIlRulIDpQLTQMuIVRLSLNlFAL+IhsPLh+pLPLRRKsspHsALHDCluLHLP-LTFps...............Dts.sscss.TPpLTlpV+pALCWHpsEGGISGPRGLTSRISVRLSEuThpshGPulFGpL.hDs.-SP.DLsLSSLhLYQDslLRFNVThcsuppphPSsP.VSFRLRLRRcTVpRPFFSDsPLPYFlPR+ps..ssGL-VplPY-LoLKsSHhlRIYRRFYGPaLGLFlPHNRQsLpMPVTlWLPRTWLEIoVlssssH...................................lP+soVLGpLYFISSKHTLNRGpLSALTaQVKSuLHspP.......pQLSlLGASluLQDLlPMRlusP..-PpsppQQpssTppspPVTlAMVCsch	......................MPRsD.sLRNtsR.sRsR+s.............................................................................h.tsspTILTLTDpHcl+pPhs+cGTY+LIQLHlDhpPp-LpcPFQILLSTsLQL.....................................Es.ss+pDscERGlLCsVuNpDSDlhPuhSlFPApsG.CpI.lRulIDpQLTcMuIVRLSLNlFAL+llsPLl+pLPLRRK..sscH..TALHDCluLHLP-LTFcs....................s-ts.TspLTlp.V+p.ALCWH..psEGGISGPRGLTSRISsRLS-sThpsLGP....ulFGpL.hDs.-SP.DLsLSSLhLYQDshLRFNV.....T..ssppphPusP.VuFRLRL.RRpTVpRPFFSDsPLPYFlPs+ps..stGL-VplPY-L..oL..KsSHpLRIYRRFYGPaLGlFVPHNR.QsLpMPVTlWLPRoWLEloVlssspp..................................phPRsslLGcLYFISSKHoLNRGpLSAhsHQVKSo.LHups.......p.QLSlLGASIuLpDLlPMRlusP..pPps..pp.ppssTp.spPVTlAMVCsp.h................................................	0	0	0	0
+6114	PF06286	Coleoptericin		Coleoptericin	Moxon SJ	anon	Pfam-B_11996 (release 9.0)	Family	This family consists of several insect Coleoptericin, Acaloleptin, Holotricin and Rhinocerosin proteins which are all known to be antibacterial proteins [1].	25.00	25.00	30.70	30.60	23.50	18.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.90	0.71	-4.29	3	16	2009-09-10 22:13:49	2003-06-03 13:36:34	6	2	8	0	2	17	0	111.00	48	95.23	CHANGED	MMKLYIlFGLIAlSAAYVVPEtYYEP.YP-sAua-utRlEP..lSPAEL+aspslsDEsEl-.P.hYIRERRSLQPGAPNFPMPGSQLPTSITSNVEKQGPNTAATINAQHKTDRYDVGATWSKVIRGPGRSKPNWSIGGTYRW	......................................................................................................................................RRSLQPGAPNhs..spp.P.h.plossluR.p.s.s.NTpusINlQ+KG-saDhsAGWSKVlRGPsKuKPTWHVGGTYRW.	0	2	2	2
+6115	PF06287	DUF1039		Protein of unknown function (DUF1039)	Moxon SJ	anon	Pfam-B_12079 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins from Escherichia coli and Citrobacter rodentium. The function of this family is unknown.	25.00	25.00	26.70	26.90	20.10	18.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.07	0.72	-4.08	5	254	2009-01-15 18:05:59	2003-06-03 13:44:08	6	1	241	0	11	57	0	65.90	55	72.96	CHANGED	lAAVNHuLhupAHAILNALPplIPDccsptlCEAlLLFGLN-pscAs+tLAs.hssE-AQsLRuLls	..hAGVNHuLhups+AhLsALs.IlPDKKlpLlC.AlLLhGLN-.hcAsKlLuD.hD..-A.hLphLh.......	0	2	5	8
+6116	PF06288	DUF1040		Protein of unknown function (DUF1040)	Moxon SJ	anon	Pfam-B_12122 (release 9.0)	Family	This family consists of several bacterial YihD proteins of unknown function [1].  	20.80	20.80	21.20	21.30	19.10	20.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.66	0.72	-3.75	15	736	2009-09-11 13:49:48	2003-06-03 13:47:46	8	2	731	1	66	206	2	85.40	78	96.16	CHANGED	MKCHRlNELlELLpPtWp.K-P-LsLlphLpKLApEuGapGsLs-LTDDVLIYHLKMRso-KsEhIPGLKKDaEDDFKTALL+ARGl	........MKCKRLNEVIELLQPAWQ.KEPDLNLlQFLQKLAKESGFDGcLsDLTDDILIYHLKMRDSAKDAsIPGLQKDYEEDF..KTALLRARGV.........	0	5	21	45
+6117	PF06289	FlbD		Flagellar protein (FlbD)	Moxon SJ	anon	Pfam-B_12586 (release 9.0)	Family	This family consists of several bacterial FlbD flagellar proteins. The exact function of this family is unknown [1].	20.60	20.60	20.60	21.40	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.66	0.72	-4.60	55	409	2009-01-15 18:05:59	2003-06-03 15:07:04	6	1	404	0	147	323	3	59.70	43	81.93	CHANGED	MIpLTRLNGc..pFhLNu-hIEpIEssPDTsITLssG+KalVpEss-EVlc+llpa+pcIht	....MIplT+L..NGp.....tFhLNschIEplEp..sPD.TsITLssG+Khl.........VcEos-EVlc+lhpa++clh.h......	0	75	120	133
+6118	PF06290	PsiB		Plasmid SOS inhibition protein (PsiB)	Moxon SJ	anon	Pfam-B_12789 (release 9.0)	Family	This family consists of several plasmid SOS inhibition protein (PsiB) sequences [1].	20.60	20.60	21.80	26.90	19.50	18.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.74	0.71	-4.77	5	311	2009-01-15 18:05:59	2003-06-03 15:14:08	6	3	206	4	8	165	0	137.20	79	96.56	CHANGED	MKTlLTLsVLpTMoupEhEDaRsAGEDhRRELSHAVMRDLTsPuGWsVNAEYRSEFGGFFPVQlRFTPuH.-+FcLAVCSPGDLSPhWllVFlosGGQPFSVVpshcsasPEtIoHTLuLlAsLDAsGYShASIIolLutEGuQ	.....MKTELTLNVLQTMNAQEYEDIRAAGSD.RRELTHAVMRELDAPsNWsMNGEYGSEFGGFFPVQVRFTPAH.ERFHLALCSPGDVSQlWh.LVL.......VNuGGcPFAVVQVQ+tFuPEAlSHoLALAAoLDAQGYSVNDIIHILMAEGGQ...............	0	1	1	5
+6119	PF06291	Lambda_Bor		Bor protein	Moxon SJ	anon	Pfam-B_12850 (release 9.0)	Family	This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the Escherichia coli host cell in animal serum. This property is a well known bacterial virulence determinant indeed, bor and its adjacent sequences are highly homologous to the iss serum resistance locus of the plasmid ColV2-K94, which confers virulence in animals. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis [1].	21.90	21.90	23.10	22.20	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.97	0.72	-10.15	0.72	-4.06	2	335	2012-10-01 23:27:00	2003-06-03 15:22:13	6	3	252	0	24	139	10	94.10	75	96.65	CHANGED	MKKMLhusALAhLITGCAQQTFTVtNK.TAVsPKETITHHFFVSsIGQ+Khl.tsKhsGGsENVVKTETQQTFVNuL.GFIThGIYTPhEsRVYCSQ	....................................................MKKMLhus.AL.A.h.LI.TGCAQQTFT..Vt....N..K.PT...A...V..s..PK...E.T..I..TH.HFF..V..S..GI.GQ.cKTVDAAKICGG.A.E.N.VVK.TETQQTFV.NGLLGFI..T..LG.IYTPLEARVYCSQ...........	0	5	10	14
+6120	PF06292	DUF1041		Domain of Unknown Function (DUF1041)	Yeats C, Moxon SJ	anon	ADDA_1192	Domain	This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with Pfam:PF00168, Pfam:PF00130 and Pfam:PF00169 domains.	20.70	20.70	20.70	21.00	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.36	0.72	-3.87	13	481	2009-01-15 18:05:59	2003-06-03 16:54:33	12	20	88	0	229	460	0	98.60	43	7.23	CHANGED	psVV+cClcsshpssYphlhspsp..hsp..t.....................tphs..ppssss+pL-.hh+LhpLslsllppsccpYu.shpt.Fs..hslhp.pAEshWoLFusDMctALEtp	.....................................ppVV+cClctsh.ssYphlhp.s+..hspt.t..........................t..c.hs......cp.sssh+pL-.h.+LhpLh..lpllpps....cppas..............s..........h.........pt.Fs...slht.pAEshWsLFA.DMchALEtp..............	0	50	65	143
+6121	PF06293	Kdo		Lipopolysaccharide kinase (Kdo/WaaP) family	Studholme DJ	anon	Krupa A, Srinivasan N	Family	These lipopolysaccharide kinases are related to protein kinases Pfam:PF00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is  necessary for resistance to hydrophobic and polycationic antimicrobials in E. coli and that it is required for virulence in invasive strains of S. enterica [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.23	0.70	-5.26	14	2201	2012-10-02 22:05:25	2003-06-03 18:59:37	9	20	1403	0	513	8874	747	187.20	22	64.55	CHANGED	spaWttpucslspspGRtssWFs.tph....pssh++YaRGshhu+ls+D.atas.hspspuhtEFpllccLcctGlsVP+slAushh+huht..apA.lLoEclssspDLsshltp.......tphppthhctlGphItchHpsslsHsDLss+sILlctpt....t..chhlIDh-+sthph..ss+WppcsLspLhRSh........slthscpDattlhpuY	..................................................................................................................................................t.................h.ht..hhhtt..h....t....phhp.s...h...h......h....s......h.........t.......sh..+Eap.hl..cc...L.p...c.....h...G....l...s..s.....s....p..s....l..u....h...t....t...t.....t....h.....s....s.........h....p...u....h...l....l..T..E.......c.l.......s....s.....s....h...s...lps.h..h.t..p........................psp.h..p...p..........t......l...l........c....t...l.u....p..h....l....t.ch...H.t.s...s.lpHs...Dhhl..pplL.l.+tst.............................thchh...lI..Dh...c..+...up......h.....+..h........t....spc...h..p....p...c..D.L..h.tL.h...................h...t..t...h..h.......................................................................	0	135	275	414
+6122	PF06294	DUF1042		Domain of Unknown Function (DUF1042)	Yeats C, Coggill PC	anon	ADDA_2448	Family	Spef is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense outer fibres of the sperm flagellum [1]. The amino-terminal domain (residues 1-110) shows a possible calponin homology (CH) domain; however Spef does not bind actin directly under in vitro conditions, so the function of the amino-terminal calponin-like domain is unclear [1]. Transcription aberrations leading to a truncated protein result in immotile sperm [2].	25.00	25.00	25.50	25.80	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.90	0.71	-4.64	6	395	2012-10-03 10:10:54	2003-06-04 11:42:13	6	13	119	1	270	374	4	139.10	24	23.64	CHANGED	LspWLpp...lspolss+shsRsFSsGhLlAEll++aaPp.lDhpsassusSlphKLsNWupl.pKsLsKLshplscslhcplhsspPGssEhLLapLhthL...p+pcppulsshptpshp.posh+h.slpppshp-ulhphhpp....u..p.lcpstslt	..............................lhpWlpp....lsloh...+sh.p....R.D.F.SsG.hLl.AEllp.pa.h.Pphl-hcsass.u.sShptKlsNWspL.................c.............+s.......Lp+...L...s..h.p..ls.p.....p.hhcsl..h.psp.s.Gsspt....lL.hpLhttl..........ppp...p...t.t....t......................................................................ttt.....................................................................	0	107	137	206
+6123	PF06295	DUF1043		Protein of unknown function (DUF1043)	Moxon SJ	anon	Pfam-B_12007 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	28.80	28.80	29.10	28.90	27.80	28.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.71	0.71	-4.50	5	884	2010-01-13 14:53:39	2003-06-04 14:20:45	7	2	879	0	118	373	38	126.10	54	92.06	CHANGED	YAlIGLlVGlIIGhlIsRLTssplKpQpslcKELEsuKtEL-pQRpELpDHFAcSAELL-TLu+DYpKLYQHMAKoSssLLPpLstpsNPFspptt.ps-cSNspE.....lppQPRDYupGAoGLl+spcKc	........................YALIGLVV.GI.IIGA.V...A.MR.F......G.NRK.....L......RQ....Q..p....uLQ.hELE.....K.sKsEL-EYRpELVoHFA+SAELLDTMA+DYRQLYQHMAKSSosL.L..P...E..l.s.s........c.....s.NP.F+.sRLs......E.....S...EA..S....NDQu............PV.ph.PRDYSEG.AS.GLLRsttK.c...........................................................	0	20	48	87
+6124	PF06296	DUF1044		Protein of unknown function (DUF1044)	Moxon SJ	anon	Pfam-B_12045 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.46	0.71	-4.27	36	879	2012-10-03 00:18:00	2003-06-04 14:22:33	7	2	693	0	167	538	38	103.50	27	90.35	CHANGED	MRlFKs+hFs+aA++ct.lsDpsLtcAlcchtpGhlDADLGGGVhKKRlucs.GpGKpGGaRollha+t..uc+hFFlaGFAKs-p.u....NIoscEltsh+plApthhshocppLspLlpsttlhEl	............................................................................p..t....h.t....h.......t.h.........t.s...h....t.......s....L...G..G..G.....lhK..hR..l..s..ps..tp........GKpGGhR....sI......h.h.h....ps.....s.p.p.ha.a..h.h.hYuKs-h.s.....sIospEhtsh+phuphh..........................................	0	34	101	130
+6125	PF06297	PET		PET Domain	Yeats C, Moxon SJ	anon	ADDA_3209	Domain	This domain is suggested to be involved in protein-protein interactions [1]. The family is found in conjunction with Pfam:PF00412.	25.00	25.00	25.80	25.40	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.37	0.72	-4.38	18	570	2009-01-15 18:05:59	2003-06-04 14:23:54	9	11	111	0	287	491	0	98.40	44	17.57	CHANGED	phshpssssoccDssssp..pYsWsPPGL.s.chlppYhphLP--KhPhlGStGt+aRp+QLlaQLPsaDp-sphCcuL.s-cEt+phc.FspppKcEuL.GhGsV+hhs	...............h...hpp.shuccsssh.sh...pYtWsPPGl..p.c....sppYhp.h.L....Pc-KhPhssS.Gt....pa..R..h+QLhpQLPsHDp-sphC.ps.L...s.......-c.E.t.+Ehc.Fsp.ppKcEAL.GhGsV+...s.......................	0	56	76	170
+6126	PF06298	PsbY		Photosystem II protein Y (PsbY)	Moxon SJ	anon	Pfam-B_12212 (release 9.0)	Family	This family consists of several bacterial and plant photosystem II protein Y (PsbY) sequences. PsbY is a manganese-binding protein that has an L-arginine metabolising enzyme activity [1].	20.40	20.40	23.30	20.90	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.59	0.72	-4.43	22	176	2009-01-15 18:05:59	2003-06-04 14:34:32	6	4	112	0	72	159	18	35.00	45	49.48	CHANGED	MDhRlllVlhPIllAuuWAsFNIG+sAlpQlpp.hhp	........D.RlllVlhPll.AhuWsLFNIhpsALsQlp+.h..p.....	0	16	49	63
+6127	PF06299	DUF1045		Protein of unknown function (DUF1045)	Moxon SJ	anon	Pfam-B_12127 (release 9.0)	Family	This family consists of several hypothetical proteins from Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.	24.30	22.60	25.60	23.80	24.20	22.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.87	0.71	-4.56	43	281	2012-10-03 21:31:48	2003-06-04 14:48:08	7	3	253	0	93	273	102	158.20	40	65.60	CHANGED	TLKAPFpLAsGtstspLhsAspsFAtphsPhslstLtlsplGsFlA..LlPssss..ssLppL...AussVppFDsF...RAPhots-luRR+sstLospQcphLpcWGYPYVh--FRFHMTLTGpL...stsppstlhshLpstasslh..psltlsslALFsEsssGssFpl	..............TlKAPF+LAssto..pscLhAAhtpFAustsPhslstLplpp...l........u....uFhA....LsPspss......stLppLAsssVpsFDtFRAPho.-.A.E.l..ARRcsptLotcQcp.LtcWGYPYVh--FRFHMTLTG.l...stpcps...t..lppsLcphass.h.ls.psltlsslALFsEsptGuPFp..............................	0	13	48	65
+6128	PF06300	Tsp45I		Tsp45I type II restriction enzyme	Moxon SJ	anon	Pfam-B_12151 (release 9.0)	Family	This family consists of several type II restriction enzymes.	25.00	25.00	25.30	25.00	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.78	0.70	-4.94	3	36	2012-10-11 20:44:44	2003-06-04 14:53:36	7	2	22	0	3	35	5	222.00	67	99.39	CHANGED	Ms..NhWTcLSIEYANQRSYLDDLFQVYsTIP-SlRoIsEKlWSNVEcAFK....RKDN....LuLIcELLN....LDLFPIKDSYlA...YLK+DKo.....ALE........RNPRTINRICGRLYEMGLNKIaEKsSEPKETNRQIGPMFKcWh+cKSLG................VEP....VDLusFIANE-DAIL..cASDclMtDFAKEaLGYpHc.....KGLDFlARFN+o.....YlIGEAKFLTDFGGHQNAQFNDAIuTIEAc.sl+AIKVAILDGVLYIcupNKMaKulsohYK-aNIMSALVLR-F...LYQ.......L	...................................................M....NhWTchSIEhANQRsYLDcLFpVYPhIP-ulREIDuKlWSNlEYHFK....pKDN....LuLIsELLN....LDLFPIKDSYhA...YLKRDKS.....ALE........RNPRTINRICGRLYEMGLNKIFEKCSEPKETNRQIGPMFKcWlNNKSLG................VEP....VDLNDFIANEsDAIL..+ASDslMuEFAKoHLNY+Hc.....KGLDFlARFNKK.....YIIGEAKFLTDFGGHQNAQFNDAISTI-sP....NlKAIK.VA.ILDGVLYIcSNNKMpKhLs.TpY+NapIMSALVLR-F...LYQI..............................	0	2	2	3
+6129	PF06301	Lambda_Kil		Bacteriophage lambda Kil protein	Moxon SJ	anon	Pfam-B_12201 (release 9.0)	Family	This family consists of several Bacteriophage lambda Kil protein like sequences from both phages and bacteria. Induction of a lambda prophage causes the death of the host cell even in the absence of phage replication and lytic functions due to expression of the lambda kil gene [1].	23.70	23.70	23.90	23.80	23.40	21.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-7.95	0.72	-4.53	3	292	2009-01-15 18:05:59	2003-06-04 15:00:54	6	2	219	0	6	103	1	42.10	66	73.92	CHANGED	MDQoLMAIQoKFsIAsFIGDcKMaREAV-AaKcWI.h.hhRpK	....MDQsLMAIQoKFsIAsFIGDEKMaREAV-AaKcWI.l.hhRpp........	0	0	0	1
+6131	PF06303	MatP	DUF1047; 	Organiser of macrodomain of Terminus of chromosome	Moxon SJ	anon	Pfam-B_12243 (release 9.0)	Family	This family, many of whose members are YcbG, organises the macrodomain Ter of the chromosome of bacteria such as E coli. In these bacteria, insulated macrodomains influence the segregation of sister chromatids and the mobility of chromosomal DNA. Organisation of the Terminus region (Ter) into a macrodomain relies on the presence of a 13 bp motif called matS repeated 23 times in the 800-kb-long domain. MatS sites are the main targets in the E. coli chromosome of YcbG or MatP (macrodomain Ter protein). MatP accumulates in the cell as a discrete focus that co-localises with the Ter macrodomain. The effects of MatP inactivation reveal its role as the main organiser of the Ter macrodomain: in the absence of MatP, DNA is less compacted, the mobility of markers is increased, and segregation of the Ter macrodomain occurs early in the cell cycle. A specific organisational system is required in the Terminus region for bacterial chromosome management during the cell cycle.	20.00	20.00	21.70	21.10	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.02	0.71	-4.29	13	737	2009-01-15 18:05:59	2003-06-04 15:36:37	7	1	719	0	67	231	1	145.90	71	97.72	CHANGED	MKYQQLENLEsGWKWpYLlKKHREGEsIT+alEpStA-suVppLlplEppPscV.cWIcpcMsPcLcN+hKQuIRA+RKRHFNAE+QHTRKKSIDL-YtVWpRLSthupchGsTLSETIshLl-EAE+KEpYucphSuLKpDL+cLLs	.................................MKYQQLENLESGWKWKYLVKKHREGELITRYIEuSAAQEAVchLLuL.....ENEPVhVssWI-cHMNP-LlNRMKQTIRARRKRHFNA.EHQHTRKKSID..LEFhVWQRLAGLAQRRGpTLSETIVQLIEDAEpKEKYAspMSSLKQDLQALL.G..............	0	5	19	47
+6132	PF06304	DUF1048		Protein of unknown function (DUF1048)	Moxon SJ	anon	Pfam-B_12247 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	29.60	29.60	29.60	30.10	29.10	29.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.21	0.72	-3.71	16	339	2012-10-01 22:34:14	2003-06-04 15:38:59	6	1	278	4	47	204	1	101.10	38	82.38	CHANGED	ppsl-pK+Ea+tacsRscsLPcDYptsaccIp+YlaphG.sschtshhtIhssll-LFEcuAA-G+sVt-llG-DVAuFsDpLls-sts..atDKaR-pLNcsls	...................t.Khls-KKEY+thh.tRl.tALPpDYphlaccIppYhWp.Fu..stsGtsM....hplhp-llDLFEpuAA-Gpplh-lsG-DVusFADpLlssst...s...as.cK.+ccLNcpl...............	0	25	39	44
+6133	PF06305	DUF1049		Protein of unknown function (DUF1049)	Moxon SJ	anon	Pfam-B_12262 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  --amino -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.13	0.72	-4.50	84	2233	2009-09-13 05:33:55	2003-06-04 15:41:11	6	3	2122	0	510	1349	240	65.60	24	60.14	CHANGED	hpNsphVslsalhupsp..hsLulllhhsFshGhllGh.Lhshhhh..h+h+hphpphp+......plpphppplsp.p	...........................pNs.p.Vshsa..l.h......s...p.sp....h.........sLs...l..l..lh..sshs..hGhllGh.llshhhh.......h+.h+h....pl.tchp+.......clpphppp.....t...................................................	0	138	316	417
+6134	PF06306	CgtA		Beta-1,4-N-acetylgalactosaminyltransferase (CgtA)	Moxon SJ	anon	Pfam-B_12320 (release 9.0)	Family	This family consists of several beta-1,4-N-acetylgalactosaminyltransferase proteins from Campylobacter jejuni [1].	20.20	20.20	20.30	21.00	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.27	0.70	-5.23	2	149	2012-10-03 05:28:31	2003-06-04 15:48:29	6	3	96	0	12	116	1	256.00	46	86.71	CHANGED	MLFQSYFVKIICLFIPFRKIRHKIKKTFLLKNIQRDKIDSYLPKKTLlQINKYNNEDLIKLNKAIIGtGHKGYFNYDEKSKDPKSPLNPWAFIRVKNEAITLKASLESILPAIQRGVIGYNDCTDGSEEIILEFCKQYPSFIPIKYPYEIQIQNPKSEENKLYSYYNYVASFIPKDEWLIKIDVDHhYDAKKLYKSFYIP+ppYcVlSYSRlDhha.p-pFalh+sppGpILKtPGDCLhIpNhNLhWKElLI-..sssaKhsTtps..pNh+ShE.LKh+pRIhFpTELNNYHFPFlKpaRtpDhhphNWlSl--FhK.YhpplpppI-.pMlphcTLKKlahpLh	......................................................................................................................t..........HpGaFsaDpcupssKSPLNPWAFIRVKNEulTLcsSLcShLPAIQRGVIGYNDC....sDGS.cEl...ILEFCKpYPS......FIPl.p.Y.....P...........Y...............El.....p.l..pN.....s.p.......S...-......c.N..p.LYs.......YYNYs..hSFIP......psEWlIKIDsDHhYDAKK..L..YK..SFYhs.cpph..csl.YsRlsFhh.stp...h..al.pstp.ht..hh.t..GDphll.s.s..a.E...................psh..shE.Lt.h+p.hhhh..p.sEL.paHFPhhK..Rptsh.ph.shlsl-..-F.hK..atc....ppIp.pMlpcchl.phh.p..h...................................................................................................................	0	6	8	9
+6135	PF06307	Herpes_IR6		Herpesvirus IR6 protein	Moxon SJ	anon	Pfam-B_12322 (release 9.0)	Family	This family consists of several Herpesvirus IR6 proteins. The equine herpesvirus 1 (EHV-1) IR6 protein forms typical rod-like structures in infected cells, influences virus growth at elevated temperatures, and determines the virulence of EHV-1 Rac strains [1].	25.00	25.00	105.90	105.80	24.10	17.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.50	0.70	-5.00	4	38	2009-01-15 18:05:59	2003-06-04 15:55:52	7	1	12	0	0	18	0	133.80	66	83.56	CHANGED	spustchh.Ns.sthlGhsYFRRCRpEhNEGaaApVPsGYFPVtPSphPshV.Vcu......hsGEsluFpslPsP+h-hRFaKQLpDGTFVRLPF.YP-EhYEsE.pPhtsRaYlpADscssSS....ssPSsLhEphFscVPsult.EthspWsGPK+lPlPscRYVLKhGaE..hp.pVTEDAFp.lsTphLRL-htst..................ss...sAt.s.ptspVpts	.ssssu.....sTGPGCEGGLGGWRLFKACRHEQEDGLYAMLPPDYFPVVPSSKPLLVKVPAPGASPDRTGGAVHFECVPAPRRPLQFFRQLYDGT........................................................................................................................................................	0	0	0	0
+6136	PF06308	ErmC		23S rRNA methylase leader peptide (ErmC)	Moxon SJ	anon	Pfam-B_12332 (release 9.0)	Family	This family consists of several very short bacterial 23S rRNA methylase leader peptide (ErmC) sequences. ermC confers resistance to macrolide-lincosamide streptogramin B antibiotics by specifying a ribosomal RNA methylase, which results in decreased ribosomal affinity for these antibiotics. ermC expression is induced by exposure to erythromycin [1].  	25.00	25.00	53.40	53.40	17.10	17.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.96	0.72	-7.11	0.72	-3.90	3	48	2009-01-15 18:05:59	2003-06-04 16:01:11	6	1	29	0	4	15	0	27.50	96	98.65	CHANGED	MLVFQMR....NVDKTSTVLKQTKNSDYADK	MLVFQMR....NVDKTSTVLKQTKNSDYADK	0	1	1	1
+6137	PF06311	NumbF		NUMB domain	Yeats C, Bateman A	anon	ADDA_13736	Family	This presumed domain is found in the Numb family of proteins adjacent to the PTB domain..	19.90	19.90	20.60	20.60	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.25	0.72	-3.88	8	177	2009-01-15 18:05:59	2003-06-05 14:09:23	7	4	74	0	80	195	0	86.40	63	15.01	CHANGED	sPaAIPRRHAPs-.LhRQGSFRGFsulupp.......SPFKRQLSLRlN-LPSThQRpp................-hpspsPlsEhEst..uts......D.SISuLCsQIosuFS	................PaAIPRRHAPlEQ..LsRQGSFRGFPALSQK.......SPFKRQLS....LRlNELPSThQR+T.........................DF.lKss.V..P..ElE......G-u............-.SISuLCoQIosuFu............................................	0	16	22	47
+6138	PF06312	Neurexophilin		Neurexophilin	Moxon SJ	anon	Pfam-B_12369 (release 9.0)	Family	This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins [1]. 	20.70	20.70	21.00	20.90	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.63	0.70	-5.10	6	508	2012-10-03 16:25:20	2003-06-05 14:41:06	7	8	43	0	338	454	0	177.90	29	47.06	CHANGED	Rlht+cssssssshtp.oshtss.........p-aWDhLus.o-lpt........s.sRsKR+Pll.pTGKhKKhFGWGDF.aSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGpGNVSVSLVPPSKlVEF-lpQQhhlEsK-SKs.FNCRlEaEKlD+upKTuLCsaDPSKlCaQ-QTQS+VSWhCSKPFKllC.lYIuFYSsDY..+LVQKVCPDYNYHS-TPYhsSG	.....................................................................thht............................................................................................................t...Kha..G.GDF.pup.l.p.o.....s....p.....L....p.....h....h..ss..G+l.s.D.asNGTapV.Fph.hsGps.sl..SVpLV.PScuVph....................................p........ph......h...c.t.p...s+s....Fps.p.h..c...........t.p.....s.p..c.s...p..c..s....s......l...s...................s.......s......s.......p......h...Cphppsps...ptsWhC.KP..h..+..l...C...hl.s..ah.p.st.......................................................................................................	0	100	120	202
+6139	PF06309	Torsin		Torsin	Moxon SJ	anon	Pfam-B_12047 (release 9.0)	Family	This family consists of several eukaryotic torsin proteins. Torsion dystonia is an autosomal dominant movement disorder characterised by involuntary, repetitive muscle contractions and twisted postures. The most severe early-onset form of dystonia has been linked to mutations in the human DYT1 (TOR1A) gene encoding a protein termed torsinA. While causative genetic alterations have been identified, the function of torsin proteins and the molecular mechanism underlying dystonia remain unknown. Phylogenetic analysis of the torsin protein family indicates these proteins share distant sequence similarity with the large and diverse family of (Pfam:PF00004) proteins. It has been suggested that torsins play a role in effectively managing protein folding and that possible breakdown in a neuroprotective mechanism that is, in part, mediated by torsins may be responsible for the neuronal dysfunction associated with dystonia [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.65	0.71	-4.25	8	383	2012-10-05 12:31:09	2003-06-05 14:44:56	6	6	102	0	205	556	182	119.00	39	36.68	CHANGED	ChFt-CCs...-scIshshpuL-pDLsspLaGQHLspclVV+olKualpss.pPpKPLVLSFHGaoGTGKNaVucIIAcNhYRsGL+SsaV+hFlAThcFP+sppl-pYKhcLpsplppohptCpRSlFIF	.........................................C.h.th.Ct......pp.....s..hp...........uLcp-Lpp+LaGQHLApc........l..l........lpAl.p.u.a.......l...s.s.......p.PcK..P.L.s.L.S.hHGaoGTGK....N....aVupllA..csl...a.p.p.G.......h.c.SsaV+...hFlu.s.......hH....FP.Ht..p..plp..h..Y.......+............cpLpphlpsslstCsp.SlFlF..................................................	0	48	64	114
+6140	PF06313	ACP53EA		Drosophila ACP53EA protein	Moxon SJ	anon	Pfam-B_12718 (release 9.0)	Family	This family consists of several Drosophila ACP53EA accessory gland (seminal) proteins.	25.00	25.00	34.90	30.30	19.40	22.50	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.30	0.72	-4.05	6	87	2009-09-10 23:46:03	2003-06-05 14:46:14	6	2	13	0	18	93	0	90.20	30	76.51	CHANGED	asKhhcCscVus-ulupLlcpsIPsVppLtpCsDY...pPtpsKspShltal+lsYpFhKKhlhccPcCLlhhlspussLl+Pahcpl-oLpClsE	....hp+hLcCscluhcususLhpcsIPsl+pLtpCssF...pP..pst..sh.shhthlclsYpFl++.lh.sp.cCLlsslpchhshlpPalppl.shpCh.....	0	4	4	11
+6141	PF06314	ADC		Acetoacetate decarboxylase (ADC)	Moxon SJ	anon	Pfam-B_12720 (release 9.0)	Family	This family consists of several acetoacetate decarboxylase (ADC) proteins (EC:4.1.1.4).	29.80	29.80	29.80	29.80	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.49	0.70	-5.02	72	670	2012-10-01 19:21:02	2003-06-05 14:46:38	6	12	525	20	280	644	110	225.10	20	74.15	CHANGED	shPl.hss....shs............st-hlhlpYcTDscslppllPt.sLclsp.......slVth.hhchssso.uhh..........sYpEsu.sl.Vp.ap................Gp....p.GsYshhhalD...scsslsuGRElhGaPKKlup.plpp.............s.ssslsGslch.suhplspsshshctps.s..tshtthpt...........s.hhh+hlPs.hsu.tsp...lscLVphthsshsht......tsasGs.usLpL.tsp.shssls..........pLsl.hclluuhahhsshs......lshsphlhc............L	.....................................................................h...............................stphhh..hh..apss.ct...l..p...pl.l......P.........t....s.....Lchsp...............slVt...h..hh..c..hs.css..u..................sYsEhuh...s.l.....Vp..ap.........................sc...............t.usa..shthhlc...sp.slsuGREl.aGaPKphAs.hs.lpp.........................................pssphtusl...sh...su.....htlsphshshtt...s......h..htt.....................hhhchlsp....ss....................hsphl.h...hpsh.th.................thh.Gs..uplpl.......t..............t.h.t.ls..........pLsl..hch.l...tu.hh.....................................................................................................................................	0	83	180	237
+6142	PF06315	AceK		Isocitrate dehydrogenase kinase/phosphatase (AceK)	Moxon SJ	anon	Pfam-B_13100 (release 9.0)	Family	This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (AceK) proteins (EC:2.7.1.116) [1].	20.80	20.80	20.80	27.90	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	562	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.86	0.70	-6.23	39	830	2009-01-15 18:05:59	2003-06-05 14:47:17	6	3	792	6	133	519	192	541.90	62	96.03	CHANGED	lAcsILpGF-paathFpplTttAcpRFEpuDWpulQpAs+cRIphYDc+VppssppLcp....hsspths..............tshWtplKptYhsLlhs+.p.ElAETFFNSVhs+lac+phhps-hlFVpsshs....csc..sh.pshh+sYhss.....ssLppslpcllp-ashphPa-DLpRDlphlhptlppphss.......hthssshplclLpslFYRNKuAYlVG+lhs..ssp.....hPFll......PlLpscsG...tLhlDslLhspsclullFSFuRuYFMV-sphPuuhVpFL+sLhPpKspuELYoulGhtKpGKT.FYR-hlpHL.cpS..sDpFllAPGIKGMVMhVFTLPSasaVFKlIKD+FussKpho+....tpVpsKYpLVKpHDRVGRMADT.EasslsFP+pRFSs-LLpELpphsPSplc...hpGD....pllI+HLYlERRMsPLNlYLcpAs-p.........p....lcpAlpE....YGpAIKpLAAANIFPGDMLhKNFGVTRHGRVVFYDYDEIpYlT-sNF.RplPtPcp.E-E...........huuEsWYSVuPpDV..F.PEc.FshFlhussplRchFhchHu-Lh-ssaWpshQppI+pGpltDVaPYcpptR	......................IAQTILQGFDAQYGRFLEVTuGAQQRFEQADWHAVQQAMKsRIHLYDHHVGLVVEQLRsI...Ts.u.p.s.sD............................ssFLhRVKcHYTcLLPDYPRFEIAESFFNSVYCRLFcHRsLoP-+LFIFSSQP.......ERRaRol.PRPLu+cFaPc.....cGhcshLhRlloDLPLRL.WpNpuRDIcYIlppLpEsLGsc........pLscs+lQVANELFYRNKAAWLVGKLls....ssu..s....LPFLLPI......Hps...-........cG...................cLFlDTCLTosAEASIVFGFARSYFMVYAPLPAALVEWLREILPGKoTAELYhAIGCQKHuKTEsYREYLsaL.p.ts...............sEpF..ItAPGIRGMVMLVFTLPGFDRVFKlIKD+FAPQKEhot....A+V+ACYQLVKEHDRVGRMADTQEFENFVL-K++IuPALht.LhpEuspKIsDLG-......pIVIRHLYIERRMlPLNIaLEQs-sQ.................Q....LRDAIEE....YGNAI+QLAAANIFPGDMLFKNFGVTRHGRVVFYDYDEICYMTEVNF.RDIPPPRYPEDE............LASEPWYSVuPsDV..F.PEE.FRH.aLCuDPRltsLFEEMHADLFcA-YWRuLQsRI+-GHVEDVYAYRR+QR............................................	0	19	60	96
+6143	PF06316	Ail_Lom		Enterobacterial Ail/Lom protein	Moxon SJ	anon	Pfam-B_12325 (release 9.0)	Family	This family consists of several bacterial and phage Ail/Lom-like proteins. The Yersinia enterocolitica Ail protein is a known virulence factor. Proteins in this family are predicted to consist of eight transmembrane beta-sheets and four cell surface-exposed loops. It is thought that Ail directly promotes invasion and loop 2 contains an active site, perhaps a receptor-binding domain [1].  The phage protein Lom is expressed during lysogeny, and encode host-cell envelope proteins. Lom is found in the bacterial outer membrane, and is homologous to virulence proteins of two other enterobacterial genera. It has been suggested that lysogeny may generally have a role in bacterial survival in animal hosts, and perhaps in pathogenesis [2].	20.80	20.80	21.70	20.80	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.13	0.71	-4.80	2	1349	2012-10-03 17:14:37	2003-06-05 14:47:45	6	3	430	0	22	1298	2	177.20	65	97.07	CHANGED	MRKlCAsILSAslhLssuGsPA.AuEHQSTLSAGYLpspTDhPGSDDLNGINVKYRYEFTDTLGLITSFSYANAEsEQKTHYsDTRWHED.VRNRWFSVMAGPSVRVNEWFSAYAhAGVuYuRVSoFuGDYhplTssctKpp-hLTtSDsuRhSpTuLsauAGVQhNPTEslsVDlAYEuSGpGDWRT-uFIVGsGY+F	.....................................MRKlhAsILSA.s.lh.L.ss.u.G...s..P.A..h..A.u..E..c..Q..uTLSAGYL..psp........T...s...s.......P.......G.......S......D......s.........L....p....GINVKYRYE.F.T.D....s..LGhlTSFSY.A....ssc........s...c..Q..h.T....+.Y............S.....D........T..R.......W.......H.E....D.SVR.N...R......WFSVMAGPSVRVNEWFSAYAM..AGVAY..SRVSTFSGDYLRVTDNKGKTHDVLTGSDDu..R..HSNT..SLAWGA.GVQFNPT.ESVsIDlAYEGS.......G...S....G....D.....W.R.T...D....GFIVGVGYKF..................................................	1	2	6	10
+6144	PF06317	Arena_RNA_pol		Arenavirus RNA polymerase	Moxon SJ	anon	Pfam-B_12490 (release 9.0)	Family	This family consists of several Arenavirus RNA polymerase proteins (EC:2.7.7.48) [1].	32.40	32.40	32.60	39.20	31.70	32.30	hmmbuild  -o /dev/null HMM SEED	2207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-14.22	0.69	-15.07	0.69	-7.99	14	233	2009-01-15 18:05:59	2003-06-05 14:48:14	6	1	46	2	0	207	0	1086.60	42	99.88	CHANGED	M-EplsElKDLlpKals-c-cLucQKhsFLuQscs+hlLhEGLKLLShhlElDSCctsuCpHNocpKoV-sILp-pGllCPoLPhVlPDGaKLsGssLILLEsFVRssPpsFEpKacpDhsKLhsLKcDLppsGITLlPllDGRosY.schhPDWssERhRaLLhcLLchuppssch.hEEpEYpRLscSLSsspsps.GlEslpsLK-sphsa.-+Lhc.hatGlNsclstscl+tclhclaphFRpcl.cpGhhcspFh+o-+ppLlppLsp..hh....hstttpsslsph.hshs+hhsllt.Lhhp.lcptpptpp.ssp.ph......p.ahplLShhNKlKuLKVhNTRRpsLLhLDlIhLshhhclhctpstthpp.....hhlGpthhuVNDRLlsl.tsh+.lcKhlppp...................spahphsp+hLp+uppsL.hsslohhhhtsD..h-hhhplu.phh.c....th+PshpYppspppthssstpphc..........t-php.L+tLSSlSLuLVNSMKTSuos+lh.NEtshtRY.tsVRC+EsYhQcF.hhcuhthhLlYQKTGEpS+CYSl.hsc......hsEhsSFYuDPKRFFLPIFSp-VLhphs-pMlSWL-hss-....lpslcsLL+hLlLsILssPSKRsQpaLQGLRYFlMAaVs-hHHh-LhsKL+.-hlTsoEhllh+LhssLhphlLspuscs...hop+FKFlLNlSYLCHLITKETPDRLTDQIKCFEKFlEPKlcFsslhVNPspsu..TtEpE-thlcuhc+FhSKchpsps-...hKpPGVS+-llShhlShFNsGpLhhpu-LKp...DPhpsShouTALDLuSNKSVVlsKhs-.GphlhpYDapKLVSssVsplsEpFppKGKYpLs.c-h-atI.+sLosLV.spppspssp-chs...........-pLsE.....-tschFcpl+psVphsls+hcpspphp...st...tpppshss...Lcplhssc....thh+hI+uElShH.VcDFDsslLst-hYcElCsuVY.sssh+spYFhpcshc.CPLshLhKNLoT+sYp-pEaFpCFKhlLlQhshsphhG+YcHhp+ppLsFp.-sh+Lc--VRISpRESNSEAlu+tLshohhTsAuL+NLCFYS-ESPTpaTSlussoG+LKFuLSYKEQVGuNRELYlGDLpTKhhTRLlEDYhEAlspphchoCLNsEKEFE+AIhsMKhsVs.GpluhShDHSKWGPhMSPhLFLshLpsLchc..cstsclc.p-sV.slLpWHlHKlVEVPFNVlpAhhpualKRpLGLMspsupoloE-FFaphFp.pGhVPSHISSVLDMGQGILHNoSDhYGLIoEpFINYsLchlasshssuYTSSDDQIoLhcpshhch.-...p-s-EaLplLEFHpaLSspLNKFVSPKSVhGoFsAEFKSRFFVWG-EVPLLTKFVAAALHNlKCKpPpQLAETIDTIhDQsVANGVslclVstIpcRT.pLlcYSsYP.sPFLhhpcpDVKDWVDGoRGYRlQRpIEslhs-s..sphIRsssRKlas+lKpGclaEEahlshlupsss-uLpshhphhus-p.phc-.LpapWLNLsuatsLRhVLRpKlh.oushsL-cEclPTLlKTlQSKLSpNFTRGApKlLuEAINKSAFQSSlASGFIGhCKohGSKCVRssptt.lYIKclhsplpsppt..s.hss.thslhhCppsLcp.........lspa.RPlLWDYFslsLoNAhELGsWVhupsph.....sphshhhsNPs.aaslKPpss+.LED+lGhNHllaSlRR.YPplFE-HLhPFMSDLsss+hpWssRlKFLDLCVALDhssEsLullSHllKhKR-EhYIVhps-LuhuHsRpspslspEhslSspclCpNFhhQlhF-ShlpPhVhTTpsLtSFhWFschhpLP-.-uttcLG.hosFl.clhppslpRsMahcDLthGYsh.shchsphhls.ssplhs.sLsspcphpslp-hhthhus.cshslclslolcap+pSpchchcRphshphphps.hphssl............hplcslshhhSGulssHhlLDshpLlhspPhFpGcps..hslsshhhcs.lsts.sptshhpplclshssahh-L.scasacllGP-sp.sPLVlccGtlhcssc+lushpsplpspslhhhlssL..-cp-tltshLssLa.ahtsss.p..t..lchsppshthhh-tacphLscsLcshs-Wh-FtsaulCaSKShsslMIpsspGshRLKGhhCR.LhtsspshE	.............l..h+.hh.p.h.p..th..Q+..hLsQ.p...lhhEGhKLLS.hlEl-Ss.tpsC.hN..ph.lp.lL.c.tlhsPsLs.lhPDGaph.spsllLLEsFVRss..pFEpKa.tDh.KL.plptDl...sl.LlPllDGRssa.sp.hs-Ws..+hR.hlhplhp..p...t..hE-.EY.RLh.SLt.h.sp..Gh-sh..l.c.t..a..pl.t.hh.sl.sphp...hh.tl.p.h..ap..l..tt.....h...p...hlt.h.............................h..p..p...hh..l......................................h..hhS.hNKlKu.+lhNTRR..hh.hDhlhh...h..................hh.t.h..sNDRhlsh..h.p.h.phh.tp......................h...h..hh.p.................l.......p...t.......................P.h.Yp..t...................................hphLSplsLuhhNSMKTu.ss+hh.Np.t..pa.t.V.hpEsa.Q.h....t....LhYQKTGEpo+CYul...................SFYsDPKRaF.slhSt.Vl.thh..MhsWlt...........ht..hhhlhl.hls.PoKR.Qh.lQshRYhlMAhssph...pL.pKl....ho.s-..h..h...lh..lht..t.p....hsthFKahLNlSYhCHhlTKETPD.......................................................................................................................................................................................................................................................................................................................................................................................................................................EuluctLsho.hhsuhL+NLCFYSp-SPppasuhusssGpLKFuLSYKEQVGuNRELYlGDLpTKhhTRLlEDa.Euhs..hphoCLNs-pEFppAlhsMp.sVp.u.hshSh.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+6146	PF06319	DUF1052		Protein of unknown function (DUF1052)	Moxon SJ	anon	Pfam-B_12539 (release 9.0)	Family	This family consists of several bacterial proteins of unknown function.	22.00	22.00	22.70	22.30	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.96	7	250	2012-10-11 20:44:44	2003-06-05 14:49:30	7	1	247	1	81	215	98	150.30	46	88.32	CHANGED	MsIlp.hs.sPLhDGRQSEpAhhVRRGsQRLLhphtausLPELsLASGRRADLluLotKGEIWIlEIKSSIEDFRVDRKWP-YRhHCDRLFFATHssVPt-IFPEECGLlLSDGYGAchlREAPEH+lAsATRKulhLpFuRsAAtRLhhAEhsshcs	..............................................+.stpAh....hltRGVpRLhh.s.hG.huslsElsLs..sG..R.RADllAlutK....GEI....WIVEIKSSlpDa.+uD...+..KWs-YRsaCDRhFF.As...cs...s.l...P...p......-......l...h......P-.-..sGLI..........lu..........D.....u....Y.....G.......A.........-..IlR-APEH+.LAuApRKulhL+FARsAAtRLhthp.....ss.............................................	1	22	51	61
+6147	PF06320	GCN5L1		GCN5-like protein 1 (GCN5L1)	Moxon SJ	anon	Pfam-B_12526 (release 9.0)	Family	This family consists of several eukaryotic GCN5-like protein 1 (GCN5L1) sequences. The function of this family is unknown [1,2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.65	0.71	-4.28	10	239	2009-09-11 00:23:16	2003-06-05 14:49:52	8	9	196	0	159	223	4	113.00	30	62.23	CHANGED	hlKEHpp+Qupp+phQE+h++EAIsuAssLTpuLVDslNsGVAQAYlNQK+L-sEAKpLpssuusFuKQTsQWLpllEsFNsuLKEIGDVENWuRsIEsDM+sIsssLEhsYcspp.sps....S	......................................................pt.p...-ct+p-Al.tus.s....s.lspsLs....c.p.L....sstVsp...ha...hNp++L-pEs+p.Lpt.pssphsKQ.osp.Wlp.hs-shspuLK......El.GDlpNWAc.lEhDhpslsp...sLchs.ctt......s.........................	0	44	78	122
+6148	PF06321	P_gingi_FimA		Major fimbrial subunit protein (FimA)	Moxon SJ	anon	Pfam-B_13339 (release 9.0)	Family	This family consists of several Porphyromonas gingivalis major fimbrial subunit protein (FimA) sequences. Fimbriae of Porphyromonas gingivalis, a periodontopathogen, play an important role in its adhesion to and invasion of host cells. The fimA genes encoding fimbrillin (FimA), a subunit protein of fimbriae, have been classified into five types, types I to V, based on nucleotide sequences. It has been found that type II FimA can bind to epithelial cells most efficiently through specific host receptors [1]. Human dental plaque is a multispecies microbial biofilm that is associated with two common oral diseases, dental caries and periodontal disease.  There is an inter-species contact-dependent communication system between P. gingivalis and S. cristatus that involces the Arc-A enzyme [2].	30.50	30.20	30.50	30.20	30.40	30.10	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-12.17	0.70	-5.20	32	270	2012-10-02 11:46:57	2003-06-05 14:50:11	6	5	62	6	21	280	1	299.40	14	54.52	CHANGED	hsuCop--sst.ssss..............Aplolsl.......tpstssssssssp....sEstIpsLslhlFs..tssth.h........scspsshpss.............h............tst....sG.stplhllAN...................................t.h.hsspshs...cht..shhtplsts.sts....tssLsMouthtss..shhsup..................ph..h.............................sssts..............p..t.ssslpLpRssA+lslsthp..........hphssp.pphtshhh..............hpplalhps...........+pp.s.h......................................................phaGs.shsp...........hssst.......................ahhu........phsshs...sthsss.s.........hsstshh......sssh	.............................hhuCsp-p.ps.s..sssst..........t.....splolsl..........tsstssp.sssssp.................sEs..p....IsslplhVFs.....tss..phh..h..................s.psspshtss...........hht...............pss.....sG.ppplhllAN..........................ts.h.ssspsls......chp.....shhsphssp...stp.............t.s...slhMouthtss.....shhssp...........................................................................................p..ttsss..lplpRssA+l..sl....hp...........................h.hs...t..ts..hhshh................................ppl.ahhth................ppp.t.h..............................................................................t.hss.th............................t..............................a..t...........................................................................................................................................................................................................................................................................	0	2	16	21
+6149	PF06322	Phage_NinH		Phage NinH protein	Moxon SJ	anon	Pfam-B_12973 (release 9.0)	Family	This family consists of several phage NinH proteins. The function of this family is unknown.	26.00	26.00	26.50	27.40	24.50	25.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.03	0.72	-4.35	4	231	2009-01-15 18:05:59	2003-06-05 14:50:30	6	2	200	0	2	53	0	62.60	66	96.08	CHANGED	MTaoVKTIPDMLlEsYGNQTEVARhLsCsRsTVRKYstDKEGKhHAIVNGVLMVHRGWsctpDt	..MTaTlKTIPDMLlEsYGNQTEVARhLsCsRsTVRKYhtDKEu+tHAIVNGVLMV.HpGhpt.hD.h.................	0	0	0	1
+6150	PF06323	Phage_antiter_Q		Phage antitermination protein Q	Moxon SJ	anon	Pfam-B_12730 (release 9.0)	Family	This family consists of several phage antitermination protein Q and related bacterial sequences. Phage 82 gene Q encodes a phage-specific positive regulator of late gene expression, thought, by analogy to the corresponding gene of phage lambda, to be a transcription antiterminator [1].  	25.00	25.00	29.00	28.90	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.52	0.70	-4.97	9	404	2009-01-15 18:05:59	2003-06-05 14:50:50	6	1	228	0	15	190	0	214.30	70	99.44	CHANGED	Mssp..LpalRpQLhsATADLSGuTKGQL.AahEpAph.DTspYpRK...+lRltDcsTGchITlsNPPlsGKQShAKGuuIsLVp.VEaSTuSWRRAVhSL-EcppAWLLWsYS-shsacaQVsIspWuWpcF...psphss++luuKThERL+pLlWLAAQsVK....sELtGc-h..YphpE.LAsLVGVopcNWScsast+WhsM+chFhpLDppALLsss+sRSpQKss..ppslAcls	..........................MNsQY.LQaVREQLhlATADLSGATKGQLEAWQEpA.F.DTGpY+RK.....K.RhhD...EVTG.....K....MIThDNPPIsGKQShAKGoSIsLVSPVEFSTSSWRRAVLSL-EHpKAWLLWCYStSlpWEaQlsITQWAWsEF...psp.usRKIAGKT.-RLKpLIWLAAQsVK....uE.LhGtEs..YEYQ-.LA.LlGVToKNWScTFTc+WVAMKHIFhpLDS-ALLhVhRTRSKQKAsF.pQslAKl.............	0	0	3	10
+6151	PF06324	Pigment_DH		Pigment-dispersing hormone (PDH)	Moxon SJ	anon	Pfam-B_12230 (release 9.0)	Family	This family consists of several eukaryotic pigment-dispersing hormone (PDH) proteins. The pigment-dispersing hormone (PDH) is produced in the eyestalks of Crustacea where it induces light-adapting movements of pigment in the compound eye and regulates the pigment dispersion in the chromatophores [1].	20.30	20.30	21.30	22.30	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.90	0.72	-6.13	0.72	-4.59	7	54	2009-01-15 18:05:59	2003-06-05 14:51:14	6	1	44	0	18	66	0	17.80	76	21.14	CHANGED	NSELINSLLGlPKlMN-A	NSELINSLLGLPKsMN-A..	0	3	5	15
+6152	PF06325	PrmA		Ribosomal protein L11 methyltransferase (PrmA)	Moxon SJ	anon	Pfam-B_12272 (release 9.0)	Family	This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.03	0.70	-5.29	31	4673	2012-10-10 17:06:42	2003-06-05 14:51:37	8	31	3837	31	1275	19899	6047	251.40	29	79.81	CHANGED	sWhElplpssp-stEs....lsshL....h-.h....G.uhuVsl.......p.Dup..........t.-psl..a..E.......sh....spt..l..pt............stlh.Ah.......astcs..-.htt.......lls.....t.....lp.t.....ht......hhh.....pts.......phpl.....ppls-pDWspsWpcha+Ph+huc+lhIsPoW.c-h...Pp....sstlslcLDPGhAFGTGTHPTTphCLphLEph.............lpsG..c....sV..l.DlGsGSGILuIAAh+LGApclhuhDlDshAVcuup-NhchN......plss..pltl...h...L.........t-...hs........p.........tph...DVlVANILAsslhpLssplhthlKssGhllhSGIlpcptctV.t.c.sh.p.p.uFpl.shhpcp-Wsslsup+p	...........................................................................................................................................................................................h......h......t.......s.....s.h...h........p.............................................................................t........................................l...u.h.......h.......t...t...............t................hh.t.........l.t..t.............................t..th.....................................t.h.p.h.......ptlt-.pDW.ptW.h.p...a.c......Ph..ph........s.....c..p...h.....h.I.h.PoW..pph.....t.............sth..l.lDP.Gh...A.F.G........TGp..Hs.T.T.t....hs..l..p...h....L.....-..p.h............................................h..s...u.....c.........sV...l...D..l..G..s..G.S..G..I......L..u....I...A........A.......t.........+.......L..............G.....A.........p........c..........l.....h.....u......h....D.....l......D....s............h.......A.......l.....p....s......u.........c.....-......N.....s.....c....h.....N............................s..l.ss.......pl...p.l.........h...........h...........................t...-.....h.................................p..............tph.D......l....l......l......A......N........I.......L........A........s.................l......h.............h.........h......................h..........t....h...h.......t.........s....G.h...h.h..h.......S...G......l...l...t...p...p........h...p.......l..h..p..th....t.t...th....t.l.........h....h..t.p...tt.Wstlhh..............................................................................................................	0	424	747	1006
+6153	PF06326	Vesiculo_matrix		Vesiculovirus matrix protein	Moxon SJ	anon	Pfam-B_13088 (release 9.0)	Family	This family consists of several Vesiculovirus matrix proteins. The matrix (M) protein of vesicular stomatitis virus (VSV) expressed in the absence of other viral components causes many of the cytopathic effects of VSV, including an inhibition of host gene expression and the induction of cell rounding. It has been shown that M protein also induces apoptosis in the absence of other viral components. It is thought that the activation of apoptotic pathways causes the inhibition of host gene expression and cell rounding by M protein [1].	20.80	20.80	21.40	39.40	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.41	0.70	-4.90	11	133	2009-01-15 18:05:59	2003-06-05 14:51:58	7	1	41	2	0	94	0	202.50	45	96.55	CHANGED	M.ppLpKhht.tt.t..s+pppsp......h...tPPuYp-.............PoAPl....hGh..-th-ph-..thph.phhhcsplplpoppPhcohp-shpslstW.cpYsG.hsp+PFa+hlhlhsuppL+tss...sssspscYsuphpGpshlhHplu.hPPhhph.csaspsaphtttptslslshplphssopcpssslhchh.....shpcpschpphhphaGL.hpppssspalh	.................................................................................ap....htEPTAPo............LGIIQsKCKRAD........WLIKSHLTITTNYEIKEWuTWDRAISDILDLYDGNPVFKPILLFVYYVLAYNARKIP....GPoNGVRYGAYFDELTTV..WHAI...PELMNQEsDYSYNHRVlHRKIQYVISFKIQMSSTKRRTSPIESFIE..VTsEGLKHTPQFTTILDRARFVYSLTGGRYVIH..................	1	0	0	0
+6154	PF06327	DUF1053		Domain of Unknown Function (DUF1053)	Yeats C	anon	ADDA_1330	Family	This domain is found in Adenylate cyclases.	21.10	21.10	21.10	21.10	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.41	0.72	-3.67	12	508	2009-01-15 18:05:59	2003-06-05 15:02:07	9	11	76	0	281	378	0	96.70	28	8.88	CHANGED	schhpsWss-+PFtplpptsp.stt.t.............................................ulshtpsph........ppstppsts.--El...D-hltpsI-thSspch...+p-clppahLhFp-suhE+cYspht-shF	................................................................pWs.st.pPF.ph.tt.pp.hs..pt.p.h..................................................................sls.tppp.............cstppp.tps--.El...s-hlhpuI....DupSsc+h...........+u-clpp..hsLhFpc.psLE+c...Yppts.shF..................................................	0	40	60	162
+6155	PF06328	Lep_receptor_Ig		Ig-like C2-type domain	Yeats C	anon	ADDA_13736	Domain	This domain is a ligand-binding immunoglobulin-like domain [1]. The two cysteine residues form a disulphide bridge.	20.30	20.30	20.30	21.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.97	0.72	-4.11	12	304	2012-10-03 02:52:13	2003-06-05 15:36:22	6	14	53	4	105	260	0	86.50	28	10.89	CHANGED	hsc.sshhhsss.llplGSshohsCllK..ppChp..psssphIlW+hp...h.Pppphphlscps..SplThsshtshps.......sLhsChlspuspcph	...........h....h..hhPsp.ll.plGSslohpCllK..ppst......ssup...pIl.Wphsht.tlPpppYphlscps..SpVThss.hsttps.......slhs..Ch.t.tp..p......................	0	6	14	37
+6157	PF06330	TRI5		Trichodiene synthase (TRI5)	Moxon SJ	anon	Pfam-B_13220 (release 9.0)	Family	This family consists of several fungal trichodiene synthase proteins (EC:4.2.3.6). TRI5 encodes the enzyme trichodiene synthase, which has been shown to catalyse the first step in the trichothecene pathways of Fusarium and Trichothecium species [1,2]. 	23.80	23.80	24.40	24.60	22.30	23.70	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.26	0.70	-5.81	3	159	2009-09-10 20:52:56	2003-06-05 17:43:25	6	2	67	40	56	165	0	252.40	45	91.90	CHANGED	M-sFPTEYFLsTuVRLLEsI+YRDSNYTREERIENL+YAaNKAApHFAQPRQQpILK.VsPKRLpASLRTIVGMVVYSWuKVSKEsMADLSIHYTYTLVLDDS.SDDPHssMLoFFDDLQAGREQKHPWWsLVNEHFPNVLRHFGPFCSLNLIRSThDFFEGCWIEQYNFpGFPGSDDYPuFLRRMNGLGHCVGGSLWPKELFDEQKpFLEIToAVAQMENWMVWVNDLMSFYKEFDD.RDQsSLVKNaVTCDEITLDQALEKLTsDTLHSScQMl-VFuDKDPclM-TIECFMHGYlTWHLCDaRYRL+EIYE+sccQETcDAtKFRKFF-QAAcVGAV-sEEWAaPsVAaclEVRAspcu-VK-uQ.pAlLoSlEss	....................................................................................................................................................................as+lo+.EhhsslSIahTYsllLDDS...p-DP..h..ssMhsYa.sDLpuGc.pQ.t.H.P.WW.tLVNEHFP.NVLRHFGPFCSLNLIRSTlDFFpGC........W....I..E.........Q...a....N...F..tG..a...P...G.......Sp...D..YPpFLRRhsGLGcshusslWPKc.FsEp...ph....FlE......h.s......sAls.phpsahsalNDlhSFYKE...s.tp-phshl.pshshspthoh.puLc.cl.sp-slpu...s.c.phhtl..h...s.ptss.phhtshptahpGahhhHh..t.RY+h.-h..........................................................................................................	0	17	28	48
+6158	PF06331	Tbf5	REX1; 	Transcription factor TFIIH complex subunit Tfb5	Studholme DJ, Wood V	anon	SWISS-PROT	Family	This family is a component of the general transcription and DNA repair factor IIH.  TFB5 has been shown to be required for efficient recruitment of TFIIH to a promoter [3].	20.30	20.30	20.80	30.30	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.13	0.72	-4.20	30	254	2009-01-15 18:05:59	2003-06-05 18:43:11	7	1	225	6	186	224	3	67.20	35	85.84	CHANGED	MspAh+G.lLlcCDPulKplllplDs.pphs....aIlE-LD.-THLllp...sshlphlKpclschhspspass.p	..............MspshK..G.VLlpC.DPuhKphlLplDpppshs..........FIlc..DL..D.-sHlhlp...sphlphLcp+lschh-pssa....t..............	0	57	94	151
+6160	PF06333	Med13_C	TRAP240; TRAP_240kDa; Med13; 	Mediator complex subunit 13 C-terminal	Studholme DJ, Wood V	anon	[1]	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood [4].	19.10	19.10	19.80	19.10	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.60	0.70	-5.94	23	356	2009-01-15 18:05:59	2003-06-06 10:13:06	7	8	224	0	227	344	0	402.80	26	25.44	CHANGED	Vlallsshspss..........uhlshsttFhsL.....pthpspsph.ts-lhLpIlPhchlhss....pphhl.s.schtsLuhslYspC....Ps.tt.tph......sss.hshlscshPcpIsF+lhss..........................pssshpcsshLHlAYs+ShDpcWlsAAWSDspGphppTpoasls.pspshpp........shpplps-IWphohsL...........hspstu+hplllsRlss.lsc-ELtpWppLssp.t.......................spplsLsllsVssssclh...........................................sss.s...s......htspspooPssssts...........shhossphtsusss.tss...................................s.................tss.t.ts-thlh....Dhsp-saullhspsLspssslpch..AltSGYLl+ps...................sss..cshhphcVNllpss..........psshcp..............lL+plLppYRsLusLspshGlpctpt..........................uhlPWHlsslt+	...............................................................................llahl.s.s..s.................t..p..shhhhtLhpta.phh.p.t.h.....t..tsph.lQllPhp.hlhp.....pp.hh...pphtplAhpsaspC....................s.t.t...pshh............hsh.hhh....hs...ph.Pp.l.......plhss........................................sps.p.c...ssLaluYs....h..S.hDp.RWlhAuhTD.hGchhcTthhs.lshs.sp............ttpp.....................shp...shpclWc.hshsl............hphs..sh.WRlVIsRl.........G.....t.lscsElc..sWshLlspts...........................................................................................ss.loh...slls.h-spsshhh...........................................................................................p.ss.s...hst...............ssthsTPtss.s.ps..............hshsoss.h.tsssss..s.............................................................................................................................................s.ts.......hs..s..s....t....h..........t..tp....ps...t..hh...p...ct...pp.............t..lhp.....sLu.GYhlpps...........................................................................................ssh..cs.h..thp..ls....hpss.................t.h.p..................................lL+.lLptYpsLuhLshs...s.ht.ctp............................ss.lPhHh.sh....................................................................................................................................................................................................................................................	2	55	103	176
+6161	PF06334	Orthopox_A47		Orthopoxvirus A47 protein	Moxon SJ	anon	Pfam-B_13263 (release 9.0)	Family	This family consists of several Orthopoxvirus A47 proteins. The function of this family is unknown.	25.00	25.00	81.80	81.70	19.90	24.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.80	0.70	-5.27	2	47	2009-01-15 18:05:59	2003-06-06 10:35:14	6	1	18	0	0	40	1	220.20	90	98.68	CHANGED	MGNKNIKPSKENRLSIL.KD+MDSFKRGS.....FREKS+ATIQRFSSLRREHlKVDHPDKFLELKRtIYtIIQKSSSIDVDKRTKLMSNIKTMMINPFMIEGLMTSLEsLDPDNKMSYSSVMILGEFDIINISDNcAAFEFINSLLKSLLL.........EYSISNDLLYsHINALEYIIKNTFNVPERQLILRsQYLTPIFSDLLKYAGLTIKSNILMWNKpFIKPVSDLYTShpLLHCVT.	..........................................MGNKNIKPSKENRLSIL.KD+MDSFKRGSWATSSFREKS+ATIQRFSSLRR...EHlKVDHPDKFLELKREIYtIIQKSSSIDVDKRTKLMSNIKTMMINPFMIEGLMTSLEsLDPDNKMSYSSVMILG.EFDIINISDNEAAFEFINSLLKSLLLLNTpQLKLLEYSISNDLLYsHINALEYIIKNTFNVPERQLILRGQYLTPIFSDLLKYAGLTI.KSNILMWNKpFIKPVSDLYTShRLLHCVTV....	0	0	0	0
+6162	PF06335	DUF1054		Protein of unknown function (DUF1054)	Moxon SJ	anon	Pfam-B_13269 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.10	21.10	21.40	22.20	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.27	0.71	-4.64	22	540	2009-01-15 18:05:59	2003-06-06 10:37:23	7	2	532	2	56	275	3	191.60	48	95.26	CHANGED	FopcDFcsFplcGL-sRMpslpppIcPKhptlGpphushLos.sG.cEhasHlAKHARRoVNPPsDTWlAFussKRGYKhhPHFQlGLW-s+lFlWhAlIaEs...pKtphupthhcphshlpp.lPscahlShDHscscsh.hsphs...LpphhcRhpsVKKuEhLlG+pls+c-slh.hss-chhphlcpsacpLLPlY	.....FpsKDFcsFsV-GLDtRMpAlpp.I+PpLcpLGEhFusahospT.G.-sFasHVAKHARRoVNPPcDTWVAFussKRGYKMLPHFQIGlaccplFlhFulhaEsc..sKsphA+s.F.cch.pt.lpp....LPcDahl...SlDHhKPsthhl+.-hspcpLpcslpRhtsVKKuEFhlu+tIsPp-tph.posctFlAhlEpTacphLPhY...........................................................................	0	21	35	48
+6163	PF06336	Corona_5a		Coronavirus 5a protein	Moxon SJ	anon	Pfam-B_13277 (release 9.0)	Family	This family consists of several Coronavirus 5a proteins. The function of this family is unknown [1].	25.00	25.00	28.10	28.10	21.60	20.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.14	0.72	-4.10	3	85	2009-01-15 18:05:59	2003-06-06 10:42:25	6	1	12	0	0	84	0	63.90	84	99.93	CHANGED	MKWLTSFGRAVISCYKuLLLTQLRVLDRLILDHGP+RoLTCARRVLLVQLDLVYRLAYTPTQSLV	.MKWLTSFGRAhISCYKuLLLTQLRVLDRLIL-HGP+RsLTCuRRVLLhQLDLVYRLAYTPTQSLV.	0	0	0	0
+6164	PF06337	DUSP	DUF1055;	DUSP domain	Yeats C, Bateman A	anon	ADDA_8548	Domain	The DUSP (domain present in ubiquitin-specific protease) domain is found at the N-terminus of Ubiquitin-specific proteases. The structure of this domain has been solved [1]. Its tripod-like structure consists of a 3-fold alpha-helical bundle supporting a triple-stranded anti-parallel beta-sheet [1].	29.10	29.10	29.20	29.10	28.60	29.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.54	0.72	-3.60	139	806	2009-09-10 16:33:45	2003-06-06 10:51:54	7	46	214	12	544	743	3	98.80	29	10.54	CHANGED	spthYllst.p.........Whppappalpts...ptt.....................................................................................................................s...........sI...s.....Nsslhpspt............................plc....pltpstD.ahll.........sp.psWphlhph.Y.u...uustlhppsht	..............................................................................................t.hYllst...p.........Wacp.Wcpa.V...thp..s.s.................................................................................................................................................................PG...........PI...D.....NosLhpsp.s.s...............................pL+.t....pLhpstD.Yhll............PpcsWphLhsh.Y.G.....Gs.slsR.h..p....................................	0	219	288	414
+6165	PF06338	ComK		ComK protein	Moxon SJ	anon	Pfam-B_13324 (release 9.0)	Family	This family consists of several bacterial ComK proteins. The ComK protein of Bacillus subtilis positively regulates the transcription of several late competence genes as well as comK itself. It has been found that ClpX plays an important role in the regulation of ComK at the post-transcriptional level [1].	19.10	19.10	19.10	19.30	18.70	18.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.78	0.71	-4.82	19	719	2009-09-11 05:13:32	2003-06-06 10:58:32	6	2	443	0	58	336	0	150.30	29	87.47	CHANGED	M......ppph..c...........YhIsptTMslhPhhpstpph..ocllEh-ssahs..h+PhcIIc+SC.+aaGSSYtGRKcuTpclhGlopKsPIhlsPppslYaFPTpSsppt-ChWluapaIcphcphctpcs.hlhFtNGpolpLslShpShcsQhtRouhL+hchpcchctptp	.......................................................................p.h.lptts.MhlhPhh..st.th..ocllchcpshh...hps.clIc+SC.+haGsoa...G.++ttopclhs...I..spK.sPIhl..sPh......h.hhFPTc...S...p.....p.sps...lWlshpa.Icshc...t...l..cs..ppp....hlpF.N.s..po.lplcl..ShpslppQhpcohhlhh.hp.p.p...st.......................................	0	15	32	49
+6166	PF06339	Ectoine_synth		Ectoine synthase	Moxon SJ	anon	Pfam-B_14542 (release 9.0)	Family	This family consists of several bacterial ectoine synthase proteins. The ectABC genes encode the diaminobutyric acid acetyltransferase (EctA), the diaminobutyric acid aminotransferase (EctB), and the ectoine synthase (EctC). Together these proteins constitute the ectoine biosynthetic pathway [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.50	0.71	-4.21	60	443	2012-10-10 13:59:34	2003-06-06 11:03:08	7	3	411	0	130	434	87	124.80	50	95.48	CHANGED	MIVRsL.p-ltsT-Rc..Vpup..sWpSpRlLLccDsMGFSFH.ThIhAGoEpchaYpNHlEuVYClpGcGclEslssGcsatIcPGshYsLscHD+HhLRApp..-h+hsCVFNPPlTGpEVHDEsGsYsh.s	..............................MIVRsl.c-hppT..-Rc..Vsup.......sWcSpRhlLtcD.sh..GFSFH.TsIaAGT-oc....lH.Y.pN.H.l...E.uVYClpGEGElE..s...l..........t.....s....G....c..sasIp.P.GolYlLDpHDcHhLR..utp..-hphsCVF..NPPlTGpElH.DpsGsYsl.t..............	0	41	87	113
+6167	PF06340	TcpF		Vibrio cholerae toxin co-regulated pilus biosynthesis protein F	Moxon SJ	anon	Pfam-B_13058 (release 9.0)	Family	This family consists of several Vibrio cholerae toxin co-regulated pilus biosynthesis protein F (TcpF) sequences. TcpF is known to be a secreted virulence protein but its exact function is unknown [1].	25.00	25.00	432.60	432.40	18.40	18.20	hmmbuild  --amino -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.97	0.70	-5.31	5	44	2009-01-15 18:05:59	2003-06-06 11:25:21	6	1	39	2	1	18	0	316.70	87	93.87	CHANGED	FNDNYSSTSTVYATSsEA.......TDSRGSE..HLRYPYLECIKLGMSRDaL-N.CVTVSFPTsS-hFYGAYPucEE...GKpRTKEDFQARLLSGDYsuLEKLYlDaYLAQTTYDWcIPTRDQIEoLVNLAK-GKLoosLNsEYlcGRFLTKsD.GcYsIVsVGsV.ADsoPVKLPAlVSKRGLMGToslVNAlPsEIaPNIK.....lYpsTlSpLcPGssFcAshEYDssELpKHGYSs....lsDVpucVLVGVPuuc.GVIYsPVYpEos+sYahSsNhPGKclYslSTNDlHNGapWSssMFSNuKY+TQlVLTKuDGSGV+LYSKAYSEpF	FNDNYSSTSTVYATSNEA.......TDSRGSE..HLRYPYLECIKIGMSRDYLEN.CVKVSFPTSQDMFYDAYPSTESD.GAKTRTKEDFSARLLAGDYDSLQKLYIDFYLAQTTFDWEIPTRDQIETLVNYANEGKLSTALNQEYITGRFLTKEN.GRYDIVNVGGV.PDNTPVKLPAIVSKRGLMGTTSVVNAIPNEIYPHIK.....VYEGTLSRLKPGGAMIAVLEYDVSELSKHGYTN....LWDVQFKVLVGVPHAETGVIYDPVYEETVKPYQPSGNLTGKKLYNVSTNDMHNGYKWSNTMFSNSNYKTQILLTKGDGSGVKLYSKAYSENF	0	1	1	1
+6168	PF06341	DUF1056		Protein of unknown function (DUF1056)	Moxon SJ	anon	Pfam-B_13260 (release 9.0)	Family	This family consists of several putative head-tail joining bacteriophage proteins.	21.80	21.80	23.20	23.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.07	0.72	-3.94	6	36	2009-09-11 05:07:47	2003-06-06 11:28:42	6	1	35	0	6	37	0	63.10	37	99.65	CHANGED	M.......IFKphFshIWclFDVLhFILAhIslslTsFhhshshGsIololshhLhGhlSElloc..pKGGD	............M.IhKphFphIWp.hFD.lLhFILuhIslslssFhhshshGslululshlLsGhlSEhlsp...Kt.........	1	2	3	5
+6169	PF06342	DUF1057		Alpha/beta hydrolase of unknown function (DUF1057)	Moxon SJ, Bateman A	anon	Pfam-B_13294 (release 9.0)	Family	This family consists of several Caenorhabditis elegans specific proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.87	0.70	-5.60	6	46	2012-10-03 11:45:05	2003-06-06 11:38:02	7	2	10	0	44	763	581	261.50	31	89.71	CHANGED	EPKhhpKLVKFpscpt+hV-lpAVYEDohsSGSshGTVVuFHGSPGSHNDFKYlRsph-chsIRFIGlNYPGFc.TsuY.sQpasNhERpsYocALL-cL-lc..GKlIhhGHSRGCENALQTAssh......ssHGlVMlNPsGhRhHKGIpPh.RhpolsalaphLPp..hlusuh......hathhculGhKVpcGEEAsuAhRuhhshuLEcQlt.I-KLpcps.sKphIsFGGKDaLlEEEIVhEsLc+apGLsHFsh.ccpIoEc-htKIhcSFsssQpGsSVFlAcDsHFQNKopA-LlAEss+uhFD	....................................................................................................hph......tp.hplp.As.YpDs..hs...s..G..os..h....G...T...V.l.u.h.HG.o.P...G.S..H.p.D.F.K.Y..lp...s..h..L....-.p..h...s..lR.hIs...lNaPGF....t......o.s...............s.h....p................p..p...a.....s..N....ER...p..s.a.s.....p...u...l....lp.pL.s..lp.....s+.l..lhlGHSRGsE.NA...Lph..u..sth...................s..h..G...hs....hl.N...s...sG....h+...H..+..u...Ip.P..h.....+.h..t.h.......ls.h...lhp...h..l.p....hhhsth......................hht.hh.chl..Gh..+...l..p...s..G...c.....A......hsuh+s..h.ph..shcpp.h....l..cchpcps..h...........+hhlsauupDaLlEccI..Ehht..ta..p.shpHa..h.ppp..s-...c.p...h....c...Ihpsa.st.s.pptsol.htp-sHa.pKppAchlucsstthh..........................................................................................................................................................................	0	21	26	44
+6171	PF06344	Parecho_VpG	VPG_P3B; 	Parechovirus Genome-linked protein	Yeats C	anon	ADDA_6741	Domain	This family is of the Parechovirus genome-linked protein Vpg type P3B.	25.00	25.00	37.30	36.00	17.80	16.50	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.28	0.72	-6.56	0.72	-3.98	4	49	2009-01-15 18:05:59	2003-06-06 12:02:01	6	2	11	0	0	50	0	20.00	88	0.92	CHANGED	RAYNPTLPVAKPKGTFPVSQ	RAYNPTLPVsKPKGTFPVoQ	0	0	0	0
+6172	PF06345	Drf_DAD		DRF Autoregulatory Domain	Yeats C	anon	ADDA_2536	Motif	This motif is found in Diaphanous-related formins. It binds the N-terminal GTPase-binding domain; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of DAD to mammalian cells induces actin filament formation, stabilises microtubules,  and activates serum-response mediated transcription ([1]).	22.10	22.10	23.30	22.70	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.16	0.73	-6.14	0.73	-3.85	3	216	2009-01-15 18:05:59	2003-06-06 13:25:51	6	12	65	11	89	181	0	15.00	91	1.47	CHANGED	GVMDSLLEALQSGAA	GVMDSLLEALQSGAA	0	13	19	50
+6173	PF06346	Drf_FH1		Formin Homology Region 1	Yeats C	anon	ADDA_2536	Family	This region is found in some of the Diaphanous related formins (Drfs) ([1]). It consists of low complexity repeats of around 12 residues.	40.00	40.00	40.50	40.40	39.90	38.60	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-12.57	0.71	-12.86	0.71	-4.72	4	113	2009-01-15 18:05:59	2003-06-06 13:37:54	7	15	26	0	46	81	1	139.50	65	14.81	CHANGED	PPPPPLP..uGssIPPsP...................PLPsGssIPPPPPLPGGssIPPPPPLPGsAu.IPPPPPLP.GssuIPPPPPLP.GusuIPPPPPLP.GussI.PPPPPLPGGuGI.PPPPPLPGtsul.PPPPPLPsGsGl.PPPPPhPG..AsGIPPPP..PGhGhPPPPP.FGhGVPssPsLP	............................................PP.sPPL.s..GssIP.sP...PPLP...GsuI.PP.PPP....LPG.su.IPP.PPPLP.Gs..uIPPPPPLP.G..s.uIPP.PPPLP.G.s.uI.PP.PPPLPGus..GI...P...P.P....PPLPGts.Gl..PPP....PPLPsGsGl...P.P.P..PPhPG..usG.IPPPP...PshGhPPP.P....t..........................................	0	6	6	10
+6174	PF06347	SH3_4		Bacterial SH3 domain	Moxon SJ, Bateman A	anon	Pfam-B_13248 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function. These are composed of SH3-like domains.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.55	0.72	-4.42	29	1011	2012-10-02 18:48:24	2003-06-06 13:57:49	8	42	560	0	333	3517	2117	55.40	27	37.89	CHANGED	cssplslRpuPsssupVs.shlcsGlssplt.pspspWp+lp.ssGtpGWltpstLhG	.............................sstlslRsuPu.tsutlh..sh....l..c.t.G.h..s.l.p.l......t....p.....p.....p.....s.......s.....W....pcl.....c...s.....s....G.....h......p.....GWltpshL.G..................	1	110	232	271
+6175	PF06348	DUF1059		Protein of unknown function (DUF1059)	Moxon SJ	anon	Pfam-B_13303 (release 9.0)	Family	This family consists of several short hypothetical archaeal proteins of unknown function.	20.50	20.50	20.80	20.50	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.71	0.72	-4.15	17	231	2009-01-15 18:05:59	2003-06-06 14:01:29	6	2	177	0	99	216	25	56.20	26	83.59	CHANGED	hK.pFpCuslGhsCuachp.AsoE-EllctlttHA+hsHGhsclPp-hlscl+psI+cs	..................h.Ctt..h..s..hs..Cshtlp.Aco-sEllctsspHAtssH.s..hs..s.s.-hhppl+t.h.......................	0	21	46	78
+6177	PF06350	HSL_N	HSL; 	Hormone-sensitive lipase (HSL) N-terminus	Moxon SJ	anon	Pfam-B_13329 (release 9.0)	Family	This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin [1].	25.00	25.00	25.10	29.80	17.70	24.40	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.84	0.70	-5.34	6	166	2009-01-15 18:05:59	2003-06-06 14:21:03	7	6	104	0	86	151	0	251.30	43	37.71	CHANGED	hDpptlFsoLhslCc-NhuaFu.....uspsEsupRLpGsasulp-HhcsscPLVppltohhHcaDFDppTPGNGYRShlaVVcsCltHhl+huRYlsuNRsoIFFRpua.ltElEAYsphLspLpshLhasQpLhphs.ssGcLF.tsEu+ssEchlpchsTlpphCFYGRCLGFQFssSIRPhLphluIGMsuFuEsYhppp..usIuhAsSShaTSGKYhlDPELRupch.pIoQNhcVcFhKuFW.lsEoElhpoLsShsuopVKVNRllolPPEslpLPhspsscho................VsIssPpAHhGsG.PVpsRLIStshRcG..u	.................................................................hhtsL..htlsp-NhsaFs...........ts.schupRl.sshhtl.p-phhtlcshltplh.thsp...haDh....D.pT..PuNGYRSll.psspsClhHhlp.hs.+hlts.sRpolFFR..t.sa.htElEAY.hthLsp.Lp.........shh....hs..ppLh.ths....psGt...L..F....s-p..........thstphlpchsolcpsCFYGRCLGF..Q.Fssul+shLphluluhsoauEp..Ytppp....suluhsspSlhooG+ahlsPELRutch.cIhQshclcFhKuFWslsE....plh..........pplsshsusslpVschlplPsp.shphPhts....s.phs.......................VsIssP..AHhGsu.PV.hRLlShchRpG..u.............................................	0	32	39	65
+6178	PF06351	Allene_ox_cyc		Allene oxide cyclase	Moxon SJ	anon	Pfam-B_13374 (release 9.0)	Family	This family consists of several plant specific allene oxide cyclase proteins (EC:5.3.99.6). The allene oxide cyclase (AOC)-catalysed step in jasmonate (JA) biosynthesis is important in the wound response of tomato [1].  	21.60	21.60	22.20	22.20	18.90	21.00	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.04	0.71	-4.82	10	96	2009-09-12 22:21:42	2003-06-06 14:28:10	6	2	48	19	35	100	1	168.90	62	71.60	CHANGED	-su+PuKVQELpVYEINERDRGSPAYLRLSpKsV.......NSLGDLVPFSNKLYoGsLcKRlGITAGIClLIQHpsEKKGDRYEAIYSFYFGDYGHISVQGsYLTY.EDTYLAVTGGSGIFEGsYGQVKLpQlVFPFKLFYTFYLKGIp.DLPpELLussVsPSPoVEPoPAAKACEPHAVlsNF	..............................................................................p.upPsKVQELpVYEINERDRsSPAYL+.L.Sp.Kps...........NuLGDLVPFoNK............LYoGsL...pKRlGITAGlClLIQHhPEK...........pG...........DRYE.AIYSFYFGDYGHISVQGsYLTY..EDo..YL..AVTGGSGIFEGsYGQVKLpQlVFPFKLFYTFYLKGIs.DLPtELlspsV.PSPsVEPsPtAKAsEPpAslsNF...................	0	10	25	30
+6180	PF06353	DUF1062		Protein of unknown function (DUF1062)	Moxon SJ	anon	Pfam-B_13377 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.80	21.80	22.00	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-3.97	15	241	2009-01-15 18:05:59	2003-06-09 11:21:01	7	1	234	0	34	162	2	140.90	45	72.15	CHANGED	lNAp+KhLDlWLIYKCspCDpTWNhslFpRhslccIsPtLL-uLpsNDtshlctaAashtsL+RNstcls.t.s-acltcchhsssssphs...lclplphshPhsl+LspLLtppLtLSRoclcpLh-pGhIpssstt...sctL+pc	.....................VNuQKKlLDVW.IYKCo+CDhTWNloLFSRlsVucIs+-LasRLhuNDsuslphaAaDsulLKRNsAELu.upPD..F+Ip-R.hll.ul.s.uapp......lsVsVRlupsFpVpLLSlLK+QLhLSsAElKRhlEsGpIoGlohK..hu+KL+..s.......................	1	14	20	25
+6182	PF06355	Aegerolysin		Aegerolysin	Moxon SJ, Bateman A, Macek P	anon	Pfam-B_13415 (release 9.0)	Family	This family consists of several bacterial and eukaryotic Aegerolysin-like proteins. It has been found that aegerolysin and ostreolysin are expressed during formation of primordia and fruiting bodies. It has been suggested that these haemolysins play an important role in initial phase of fungal fruiting. The bacterial members of this family are expressed during sporulation [1].  Ostreolysin was found cytolytic to various erythrocytes and tumour cells [2]. It forms transmembrane pores 4 nm in diameter. The activity is inhibited by total membrane lipids, and modulated by lysophosphatides. The potential use of aegerolysins is reviewed [8] with special emphasis on their properties which would allow thier use in therapeutics.	20.60	20.60	21.10	21.80	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.63	0.71	-4.28	18	123	2009-01-15 18:05:59	2003-06-09 11:40:34	8	1	67	0	67	114	0	120.00	26	84.40	CHANGED	uQWVplcIhsphsptslpI+NspLshG+aacsss+cpploss-lsthhIts.ssptplsusGRpss.oGTEGshDlh...Du..-p+IsplaWDsPauu.+sNpaphpcpsscYtlEhushs.psuGslGsVslcl....s+p	.......................................phlt..hplhs.phs.tt.sltlcNspLph.....GKaa...p.ss.......cspclossplsthshts.ssph...plsusGRpsssoGTpGshDlh........ss..s..p+l..spl..hWDs.Pasu..sNpaph...ps...ts.....sp...Ytlthsuhs..p.sshGplslpl...t........................	0	11	37	56
+6183	PF06356	DUF1064		Protein of unknown function (DUF1064)	Moxon SJ	anon	Pfam-B_13437 (release 9.0)	Family	This family consists of several phage and bacterial proteins of unknown function.	24.60	24.60	25.00	24.80	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.66	0.71	-4.10	5	417	2012-10-11 20:44:44	2003-06-09 11:42:11	6	1	361	0	39	303	62	112.80	39	85.21	CHANGED	+SKYNAKKVEaDGIVFDSKsEspYYQpLcsshsusph-+l-lQPKFELhsK.FRKsGpl.RsIcYlADFslRp-u.cllEVIDVKGMlT...c-a+IKAKLFch+Yhp......hKs.KhpGpsahps	..................................hsKYsuKK.lp.h.cGIsFDSKsEscYYph.Lcp....p..pss....p.h..s...cl-lQP+FEL.s............p....h...p...........p.p....................R...sIpYlADFslap.ps...t............hl....c.VlDVKG...hhT.....cshplKtKlFchp....Y.p......h.h.h..p........................................	0	13	26	29
+6184	PF06357	Omega-toxin	Omega-atracotox;	Omega-atracotoxin	Moxon SJ	anon	Pfam-B_14633 (release 9.0)	Family	This family consists of several Hadronyche versuta (Blue mountains funnel-web spider) specific omega-atracotoxin proteins. Omega-Atracotoxin-Hv1a is an insect-specific neurotoxin whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels [1]. 	21.70	21.70	23.10	22.20	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.12	0.72	-4.37	2	17	2012-10-01 22:06:18	2003-06-09 11:58:20	6	1	5	2	0	20	0	37.10	79	71.75	CHANGED	SssCIPSGQPCPYsc.CCStSCTaKpNENGNoVpRCD	..SsTCIPSGQPC.PYNENCCSpSCTaKp.NENGNTVKRCD.	0	0	0	0
+6185	PF06358	DUF1065		Protein of unknown function (DUF1065)	Moxon SJ	anon	Pfam-B_14830 (release 9.0)	Family	This family consists of several Benyvirus proteins of unknown function.	25.00	25.00	50.00	49.90	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.58	0.72	-4.33	2	32	2009-01-15 18:05:59	2003-06-09 12:33:53	6	1	5	0	0	18	0	99.80	96	94.41	CHANGED	MVLVVKVDhSsIVLYIVAGsVVVShLYSPFFSN-VKAuuYAGAlF.suGCIMDRNSFAQFGuCDIPKaVA-SIo+VAhKEhDADIhschssVss+hVsLhEslh.lh.RlF	MVLVVKVDLSNIVLYIVAGCVVVSMLYSPFFSNDVKASSYAGAVFKGSGCIMDRNSFAQFGSCDIPKHVAESITKVATKEHDADIMVKRG-VTVRVVTLTETIFIILSRLF	0	0	0	0
+6187	PF06360	E_raikovi_mat		Euplotes raikovi mating pheromone	Moxon SJ	anon	Pfam-B_14708 (release 9.0)	Family	This family consists of several Euplotes raikovi mating pheromone proteins. Diffusible polypeptide pheromones, which distinguish otherwise morphologically identical vegetative cell types from one another, are produced by some species of ciliates. In the marine sand-dwelling protozoan ciliate Euplotes raikovi, pheromone molecules promote the vegetative reproduction (mitogenic proliferation or growth) of the same cells from which they originate. As, understandably, such autocrine pheromone activity is primary to that of targeting and inducing a foreign cell to mate (paracrine functions), this finding provides an example of how the original function of a molecule can be obscured during evolution by the acquisition of a new one [1].	25.00	25.00	51.10	50.70	17.60	17.20	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.55	0.72	-3.74	6	6	2009-01-15 18:05:59	2003-06-09 13:02:30	6	1	1	6	0	12	0	35.30	37	62.72	CHANGED	DhC-pAsAQCshThCp.hCt...sp.hC.lsVhss..Cs	DhC-pAsAQCshThCp.hCt...sp.hC.lsVhss..Cs	0	0	0	0
+6188	PF06361	RTBV_P12		Rice tungro bacilliform virus P12 protein	Moxon SJ	anon	Pfam-B_14960 (release 9.0)	Family	This family consists of several Rice tungro bacilliform virus P12 proteins. The function of this family is unknown [1].	25.00	25.00	25.50	67.40	23.60	18.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.42	0.72	-3.82	3	11	2009-01-15 18:05:59	2003-06-09 13:05:48	6	1	2	0	0	11	0	100.10	90	100.00	CHANGED	MSADYPTFKEALEKFKNLESDTAAKDKFNWVFTLENIKTTADVNLASKGLVQLYALQEIDKKINNLTAQVSKLPTTSGSSS.AGAIVPAGSNTQGQYKAPPKKGIKRKYPA	MSADYPTFKEALEKFKNLESDTAuKDKFNWVFTLENIKTTADVNLASKGLVQLYALQEIDKKINNLTAQVSKLPTTSGSSS.AGAIVPAGSNTQGQYKAPPKKGIKRKYPA	0	0	0	0
+6189	PF06362	DUF1067		Protein of unknown function (DUF1067)	Moxon SJ	anon	Pfam-B_15074 (release 9.0)	Family	This family consists of several hypothetical Mycobacterium leprae specific proteins. The function of this family is unknown.	25.00	25.00	25.40	213.20	23.90	22.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.32	0.72	-3.43	2	7	2009-01-15 18:05:59	2003-06-09 13:07:25	6	1	1	0	0	7	0	97.00	97	76.46	CHANGED	MTTPTPQGHDMHTKTPLPRGANNYPHTHACIDIAFSTAQVPSPWHHQHVDQAASTTDMLTCAALIVSTAAKHTKPHRKQAVSHPsTKTPQHSppR.p	MTTPTPQGHDMHTKTPLPRGANNYPHTHACIDIAFSTAQVPSPWHHQHVDQAAsTTDMLTCAALIVSTAAKHTKPHRKQAVSHPPTKTPQHSKTRQQ	0	0	0	0
+6190	PF06363	Picorna_P3A		Picornaviridae P3A protein	Yeats C	anon	ADDA_6741	Family	This family consists of the P3A protein of  picornaviridae. P3A has been identified as a genome-linked protein (VPg) and is involved in replication ([1]).	21.10	21.10	21.10	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.36	0.72	-4.01	4	57	2009-01-15 18:05:59	2003-06-09 14:59:20	6	4	18	0	0	59	0	99.70	76	4.63	CHANGED	phhs.lcE.hphphspLIEthEshhtPpsSsFtCFAsph.s.K.+.pAscKVhsWsps+hpphhsFV.RNKuWhTlhSsloShlSILhLVhhhaKKEcpc-E	..........DAIPYIDEYLNIEMSTLIEQMEAFIEPRPSVFKCFAoKl.usps+.KAuKEVV-WFSsKIKSMLSFVERNKAWLTVVSAVTSAISILLLVTKIFKKE-SKDE.........	0	0	0	0
+6191	PF06364	DUF1068		Protein of unknown function (DUF1068)	Moxon SJ	anon	Pfam-B_14602 (release 9.0)	Family	This family consists of several hypothetical plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	25.00	25.00	35.60	33.60	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.29	0.71	-4.66	3	84	2009-01-15 18:05:59	2003-06-09 15:51:09	7	5	22	0	54	84	0	152.60	49	70.17	CHANGED	MA+HTAALKlGLALLGLSMAGYILGPPLYWHLTEALAtVSAoSCPACsCDCSohPLLTIPptLSNuSFsDCAK+DPEV.....NEDTEKNYAELLTEELKQREAEShEKHKRADsGLLEAKKlTSSYQKEADKCNSGMETCEEAREKAEcALVEQKKLTShWEERARQKGWK-GuTKPsVK	..............................hhlhuls.shhlhGPsLYW+............h..........tp......sh...s........................t.........ts.......s.....CssC.....CDC.....s.s..sl.hpls........ph..pDCu+pDP-l.....scEhEKsas-LLsEELKLpEt.ApEppc+ss.hsLlEAK+lASQYQKEA-KCNuGhETCEEARE+AEusLscp+KLTuLWEpRARQhGWccs.......t.........	0	6	37	46
+6192	PF06365	CD34_antigen		CD34/Podocalyxin family	Moxon SJ	anon	Pfam-B_14609 (release 9.0) & Pfam-B_17463 (release 8.0)	Family	This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation [1]. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an  anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion [2].	24.40	24.40	24.60	24.70	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.41	0.71	-4.67	8	185	2009-01-15 18:05:59	2003-06-09 16:06:09	7	2	43	0	85	157	0	179.50	35	45.08	CHANGED	lLsLsEsosCEcatpsscEpLlc.llCcshpushs..tstColpLApspssppsllhslsscsplssp...hphL+c+ps-LcchGIp-hshpcpusccshpc+..hs.hlIslVshuu.lLLlhslhshYssapRcS.+hspQRLsEELphVENGhHDNPTL-Vh.EsuSEMQEK+.ssLNGEhs-....SWhsP...hss.sKcDl.-....EEDTHL	................................................................hLphscs..C..t.hppp.pstp.Lhp.llCpt.ttphss...tts.Cpl.Lupsp.p.ppllh...slsscptlssp....hphLccp.ppcL.c.clGIpsh..shts.sstpshpp+......hlIsLVs.G..hLLslhhhshYhhh.pRRS.p.stpRL...sE-h.h.sE.NG.psssslpsh..tspsEhQcK..sslNtth.t-.........p...hhs......sp.h+pch.......tDTcL................	0	3	7	29
+6193	PF06366	FlhE		Flagellar protein FlhE	Moxon SJ	anon	Pfam-B_14631 (release 9.0)	Family	This family consists of several Enterobacterial FlhE flagellar proteins. The exact function of this family is unknown [1].	25.00	25.00	31.20	30.90	24.80	23.00	hmmbuild  --amino -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.23	0.72	-4.18	13	533	2009-01-15 18:05:59	2003-06-09 16:11:06	8	1	520	0	49	181	1	97.60	72	81.20	CHANGED	GssLspRG.sssSsPLpssssls..sGhlToVsWRYplsussPsGLpl+LCsto..RCVtLsG.usGpTcuFsG.sAspshpFlaclsGpGpL.PsLpVpSNQVlVNY...R	...............GlTLsaRG.ShSSuPLosp.pPs.......u.G.lMTLVAWRYQLhG.P...TPuGLRVRLCSQS..RCVEL-G.QSGTTsAFuGlsAsEPLRFlWEVPGGGR.L.IPsLKVppNpVIVNYR..........	0	3	15	29
+6194	PF06367	Drf_FH3		Diaphanous FH3 Domain	Yeats C	anon	ADDA_2536	Domain	This region is found in the Formin-like and and diaphanous proteins [1,2].	20.00	20.00	20.10	20.00	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.06	0.71	-4.91	37	1087	2012-10-11 20:01:00	2003-06-09 16:19:41	11	51	230	17	649	1003	4	187.70	26	17.15	CHANGED	suappllcAhhshtthtt..psRF.psllsshcp...................pspplchpsusMthINtllsss...p.-.........lphRlHLRsEhhthGLpcllschcph....cs-pLppplphFcppctcDhp-lh..........p+hc........shpl-hccssplhchl...hpplpcopupshh.lSlLQHlLLh.......psctttt.phhcll-phlsplslppph.t.........ppctslphslppL.......lc	..........................................uachlLpAhsphtphpt..ppRF..psllpthcp........................................................ppsslphtlAsMphINsllpus......-..-..............lpaRlHLR.EF....hphGL.....p....p.hLp..c.L.+ph................cs-p.Lp....hQlp.hap-p.tttD.tpLh..............................................cchc.........................shph...s.h.....c.......ps..p...p...l...hphl...........hpp.l.pc.o.ps.pshh...lShLp+hLhh...............pc...ttt.phhpl.l-phlpplsh.pph.p...........p.php..ht............................................................................................................................................................	1	194	270	470
+6195	PF06368	Met_asp_mut_E		Methylaspartate mutase E chain (MutE)	Moxon SJ	anon	Pfam-B_14693 (release 9.0)	Family	This family consists of several methylaspartate mutase E chain proteins (EC:5.4.99.1). Glutamate mutase catalyses the first step in the fermentation of glutamate by Clostridium tetanomorphum. This is an unusual isomerisation in which L-glutamate is converted to threo-beta-methyl L-aspartate [1].	25.00	25.00	72.00	44.00	21.70	21.00	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.49	0.70	-6.30	5	223	2009-09-11 06:01:28	2003-06-09 16:20:39	6	3	212	6	51	172	5	425.00	53	90.69	CHANGED	lPs+KRFu+tLc+Asp-GKlLsQPRAGVuLLDEHIcLLcsLpcEGuADLLPoTIDSYTRpN+YEcAtlGLc+St-uspShLNGFPlVNHGVcuCR+llcuV...-hPlQVRHGTPDARLLAElslAuGFoSaEGGGISYNIPYoKuVsL-col-sWQYCDRLlGhYEEpGl+INREPFGP.LTGTLVPPSlSpAluIlEGLLAsEQGVKsITVGYGQsGNlsQDIAAl+AL+ElupEYLssauasDlsloTVFHQWMGGFPcDEuKAaulIuhuuslAuhSGsTKVIVKoPcEAsGIPTusuNAsGL+sT+phLsMl-cQ+ls.h-sl-pEpulIKcEs+uILcKlFELGcGDlA+GTV+AFEsGVLDIPFuPScsNAGKhhPsRDssGslRlL-hGsVPlsc-lcphH+c+lcERAchEGRElSFQMVlDDIhAVScGRLIGRP	.............................lPcpKpFuhtLhcAcpcG+TLsQPRAGVALh-EHIcLLcsLp-E..sDLLPoTIDuYTRlNRY-EAtsGIccSl-uGpShLNGhPlVNHGVsuCR+lsEsl...ptPlQlRHGTPDARLLAEIuhAuGFTSaEGGGISYNIPYuKcVoLE+SIccWQYsDRLhGh.YE.Ep.GlcINREPFGP.LTGTLlPPhISpulAIIEGLLAlEQGVKSITVGYGQsGsLsQDlAAIpuLRELucEYhppaGa...sDhcloTVFHQWMG..GFPcDEuKAFulISaGAulAuhuGATKVIsKoPHEAhGIPTstANhpGL+so+Qh.L.s.Mls-.QchP...s.ssl.-hE.h.ElIKpEsRAlLsKVaELG..sG.DlA+GTVhAFEAGVLDVPFAPuttNA.GKllPsRDNsGAIRlL-sGslPlsc-Ih-hH+chlt.ERA+hEGRpsoFQMVlDDI.AlS+u+LlGRP.........................	0	21	37	46
+6196	PF06369	Anemone_cytotox		Sea anemone cytotoxic protein	Moxon SJ	anon	Pfam-B_14701 (release 9.0)	Family	Sea anemones are a rich source of cytotoxic proteins. Cytolysins comprise a group of more than 30 highly basic proteins with molecular masses of about 20 kDa. Cytolysins isolated from the sea anemone, Heteractis magnifica, include magnificalysin I (HMg I), magnificalysin II (HMg II) and Heteractis magnifica toxin (HMgtxn). These are highly homologous at their N-terminals. HMg I and II have molecular masses of approximately 19 kDa, and pI values of 9.4 and 10.0, respectively. Cytolysins isolated from other sea anemones Actinia tenebrosa (Tenebrosin-C, TN-C), Actinia equina (Equinatoxin, EqT) and Stichodactyla helianthus (ShC) exhibit pore-forming, haemolytic, cytotoxic, and heart stimulatory activities [1].	25.00	25.00	25.00	25.20	20.90	24.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.21	0.71	-4.86	3	46	2009-01-15 18:05:59	2003-06-09 16:28:07	7	1	24	19	21	55	0	153.10	36	87.33	CHANGED	-VAGAVIDGASLoF-ILcKVL-ELGKVcRKIAVGVDNESGtTWTALNTYFRSGTSDVlLPacVPNoKALLYoGRKS+GPVATGAVGVLAYhMSsGNTLAVMFSVPFDYNWYSNWWNVKIYcGKRRADQ+MYEELYYN.NPaRGDNGWapRNLGY.GLKhRGFMTSuG-AKLpIHISK	...............................................................................hpRplslthpN.oshph.hs.t...sYh.SGtsp..ls..l...tpshhhshpKspGs.sATGuVGVlsYt..h......ss......u......p......T......lAlMFSVPaDYNLYSNWasVtl..ap.sp+..p..sDpphYcphY.s.........s..s.....h....cs.c.s.sht..pt..........uh.....ul.......c.......hcuhMss.GpAhlplcl............................................	0	3	8	17
+6197	PF06370	DUF1069		Protein of unknown function (DUF1069)	Moxon SJ	anon	Pfam-B_14815 (release 9.0)	Family	This family consists of several Maize streak virus 21.7 kDa proteins. The function of this family is unknown.	25.00	25.00	28.20	204.90	20.50	18.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.24	0.70	-4.96	2	13	2009-12-01 13:51:58	2003-06-09 16:30:04	6	1	13	0	0	7	0	197.60	99	100.00	CHANGED	MGSKCKAIAGGNDHVQSSSLDGTNSSVRYILPLRSHSQPTRELVEVDVALARLPTsIRWRNVRTNPPVGLHVEQPTPFHHEAMTQLPAHLPCRRPGFEGVRVGKYSLRGRSLSAGSGVIHQPHHTGSGVGVPAGCRVSNEVVVDGNLVRQSLAGVAVAlVRSSGIGVDEVTYASGGDRYHGGPGMLECLDLEGWPIGLAASPLQPS	MGSKCKAIAGGNDHVQSSSLDGTNSSVRYILPLRSHSQPTRELVEVDVALARLPTCIRWRNVRTNPPVGLHVEQPTPFHHEAMTQLPAHLPCRRPGFEGVRVGKYSLRGRSLSAGSGVIHQPHHTGSGVGVPAGCRVSNEVVVDGNLVRQSLAGVAVALVRSSGIGVDEVTYASGGDRYHGGPGMLECLDLEGWPIGLAASPLQPS	0	0	0	0
+6198	PF06371	Drf_GBD		Diaphanous GTPase-binding Domain	Yeats C	anon	ADDA_2536	Domain	This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.08	0.71	-4.94	20	1367	2012-10-11 20:01:00	2003-06-09 16:33:03	8	48	240	17	827	1229	2	151.50	21	17.18	CHANGED	htps.s-cplpphFtcllc-h...sLsccc+...cshhshshpcKWphlhpcppsphpt.............................pppspptSPcaYlcpLpssshsp..............ppLcSLpVuLpopPluWVppFhphpGhssLhslLpphppcpsps............p.shcpcacll+CLKAlMNNpaGhcpsLs..pppslhhlupSLsosp.pTpphsh-lLosLCl	.............................................................................................................................................th............sls...p.t......t...h...t.h..s..hK.hphh.p...................................................................................................................................tt.......st.hh.p.h.t............................................phlppL..c...ht......L......p...........s......p....h.........s.........WlppF...........t..........p..Gh....shLhp....hL.tt.......h............t.........................................................................p....h.hlhC.l.+AlM.......N...p.p..................G.h.......p...h..h.ht............p.p.s.......l....ls.u.l.....s.....tp.........t...hhh...s..h..clLshlC...........................................	0	248	348	591
+6199	PF06372	Gemin6		Gemin6 protein	Moxon SJ	anon	Pfam-B_14816 (release 9.0)	Family	This family consists of several mammalian Gemin6 proteins. The exact function of Gemin6 is unknown but it has been found to form part of the Pfam:PF06003 complex. The SMN complex plays a key role in the biogenesis of spliceosomal small nuclear ribonucleoproteins (snRNPs) and other ribonucleoprotein particles [1].	25.50	25.50	25.90	25.80	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.24	0.71	-4.93	2	70	2009-01-15 18:05:59	2003-06-09 16:41:22	7	1	63	2	51	78	0	152.90	40	95.14	CHANGED	hspWhchS..papsas.K.V+llhs-.+phcGWlhssDPVStsllLsp.hE.GthSsoslhGHulpphEh.pEh-aph...EKL.asatph-spGa...DLEc++oslh+WLEKN+lsVT.p...pchlCVhGVLsI-PPYs.EsCpSSN.IILpRIQcLIQsh.sspp	............................tW..hsPhpapsYlhKpV+Vpss.-tpcacGWlhTsDPVS......usl.VLl.....shhE.c.u.p..h..o.l.pslhGHAVpsVEsls..-.u...-.....p.....ps+....E+L...chFh..st...-.s..p.u..hS......E-...LccRKs.....sL+cWLccN+IPlsE....pucstpoL.sVA.GVLTI-PPYsPEsCsSoNpIILuRlQsLIpsh................	0	15	18	34
+6200	PF06373	CART		Cocaine and amphetamine regulated transcript protein (CART)	Moxon SJ	anon	Pfam-B_15325 (release 9.0)	Family	This family consists of several cocaine and amphetamine regulated transcript type I protein (CART) sequences. Cocaine and amphetamine regulated transcript (CART) peptide has been shown to be an anorectic peptide that inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. The C-terminal part containing the three disulfide bridges is the biologically active part of the molecule affecting food intake. The solution structure of the active part of CART has a fold equivalent to other functionally distinct small proteins. CART consists mainly of turns and loops spanned by a compact framework composed by a few small stretches of antiparallel beta-sheet common to cystine knots [1]. 	21.10	21.10	21.60	22.40	19.80	18.20	hmmbuild  --amino -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.56	0.72	-4.02	9	78	2009-09-10 15:42:36	2003-06-09 16:46:50	6	2	44	1	33	82	0	70.40	66	65.26	CHANGED	sss.spEK-L...ltALpEVLEKLQsKRIs.hEKKhGpVPhCDlGEQCAlRKGuRIGKLCDCPRGosCNaFLLKCL	......................p..p.ppEKpL...l-ALQEVLcK.....LcoKRI..PlaEKKaGQVPhCDsGEQCAVRKGARIGKLCDCPRGosCN.FLLKCL..........	1	1	7	15
+6201	PF06374	NDUF_C2	NDUFC2; 	NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)	Moxon SJ	anon	Pfam-B_15334 (release 9.0)	Family	This family consists of several NADH-ubiquinone oxidoreductase subunit b14.5b proteins (EC:1.6.5.3).	21.70	21.70	21.90	24.10	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.68	0.71	-4.09	5	104	2009-01-15 18:05:59	2003-06-09 16:51:15	6	2	82	0	56	110	0	105.50	39	95.41	CHANGED	uRsss-PLcFLPD....EARSLPPPKLsDPRLlasGlLGYCoGLhDNhlRRRPVhhAGLHRQLLFlTuFVFAGYYalKRcNYhYAVRD+-MFuYIKLHPEDFPEKDKKTYGEVLEsFHPVR	....................................s.........hLss....csp.LPP..Ptlhs.st..lahGh.hGassu..l..lsNhl....p....RRPhh.uGlHRplLasoshhhhGYalsKhpshh....aAt+DpphhpYlcLHPEDFs...c...p.-+..Kpau..-lhE.ahPlR........	0	14	19	38
+6202	PF06375	BLVR		Bovine leukaemia virus receptor (BLVR)	Moxon SJ	anon	Pfam-B_14559 (release 9.0)	Family	This family consists of several bovine specific leukaemia virus receptors which are thought to function as transmembrane proteins, although their exact function is unknown [1].	26.40	26.40	26.90	26.90	25.00	25.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.33	0.71	-4.39	16	148	2009-01-15 18:05:59	2003-06-10 10:48:18	6	9	89	2	77	143	0	137.40	48	14.42	CHANGED	.opEElc+RREARphEQsNNPaYLKuuspspsutss.........htsh-cIPlspI-Lsl....PLc.....lsG.......hhtSDKYlptppppp..........pcKscK........KcKK++++.....pKcupph....sss---D......tPlchVNpshtE.MPEGAp.SD...pcccstcssDPHRALDIDL-	....................................................h.sEEELtRRREAR+pEQANNPaYlKSSPospKphpss..............sslE+IP..VspIDLoV....PLK..............VPG.......hshSDpYlKh--cR+.........tp.cKcK+..........K+K+pccc.....cKttp+hpts.toES-EDh.....sPsp.Vshss.tE.MPEsAhsSD.....-...-cpDPNDPa+ALDIDLD..................	0	26	31	58
+6203	PF06376	DUF1070		Protein of unknown function (DUF1070)	Moxon SJ	anon	Pfam-B_14060 (release 9.0)	Family	This family consists of several short hypothetical plant proteins of unknown function.	25.00	25.00	30.30	30.30	21.20	15.90	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.51	0.72	-4.09	15	109	2009-01-15 18:05:59	2003-06-10 10:50:05	7	2	18	0	64	105	0	34.80	61	50.00	CHANGED	Asus...t..s.DGpslDQGIAYlLMhsALslTYLhH	............APAP.....AP.oSDGpuIDQGIAYlLMllALlLTYLlH..	0	4	35	50
+6204	PF06377	Adipokin_hormo		Adipokinetic hormone	Moxon SJ	anon	Pfam-B_14600 (release 9.0)	Family	This family consists of several insect adipokinetic hormone as well as the related crustacean red pigment concentrating hormone. Flight activity of insects comprises one of the most intense biochemical processes known in nature, and therefore provides an attractive model system to study the hormonal regulation of metabolism during physical exercise. In long-distance flying insects, such as the migratory locust, both carbohydrate and lipid reserves are utilised as fuels for sustained flight activity. The mobilization of these energy stores in Locusta migratoria is mediated by three structurally related adipokinetic hormones (AKHs), which are all capable of stimulating the release of both carbohydrates and lipids from the fat body [1].	22.90	22.90	22.90	24.20	22.50	22.00	hmmbuild  --amino -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.44	0.72	-3.82	15	60	2009-01-15 18:05:59	2003-06-10 11:50:57	6	4	44	0	22	63	0	52.90	42	44.60	CHANGED	QLNFoPsW..GKRuususu................................tssC+s.ss-slhhIY+lIQsEAp+llpCpc	.QLsFSPsW..GKRSssssu................................tssC+s...ss...-sLhtIY+hlQsEAp+hlpCpp........	0	8	10	19
+6205	PF06378	DUF1071		Protein of unknown function (DUF1071)	Moxon SJ	anon	Pfam-B_14587 (release 9.0)	Family	This family consists of several hypothetical bacterial and phage proteins of unknown function.	20.50	20.50	26.80	27.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.05	0.71	-5.10	11	191	2009-01-15 18:05:59	2003-06-10 12:28:58	6	1	183	0	11	110	95	162.20	42	77.30	CHANGED	pohFEpLusIcVsc+lEK....KssLoYLSWAaAWsplKKthPsATapl+cFst.th.t.sh.........sahcophGahVpVsVTl....cslocpphLPVhDaRNKsl.................tK..PosFDINpolhRCLVKAlAhaGLGLYIYuGEDLP.........ch.pp.pp.pshppp.tpppsthsp	...................................olFEpLsshsVN-+hEp..............K...s..sLsYLSWuaAapElKKlpPssohcltEas..s.p.s.sY..........ahsstpGa.hVpVuVTV....csh..TcspaLP..VhDaRNK.ul...............................tK..sTsFDINKuhpRChVKA.lAh.H.GLGLYIYsG.EDL.Ppss...p.tclp-c.pph.s.pQphtc.tsh..ppt..........................	0	3	8	9
+6206	PF06379	RhaT		L-rhamnose-proton symport protein (RhaT)	Moxon SJ	anon	Pfam-B_14617 (release 9.0)	Family	This family consists of several bacterial L-rhamnose-proton symport protein (RhaT) sequences [1,2].	19.00	19.00	19.70	19.70	18.90	17.70	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.36	0.70	-5.46	2	639	2012-10-02 19:55:49	2003-06-10 12:32:38	7	2	582	0	70	330	44	313.70	70	99.30	CHANGED	MsNAIhhGIhWHLlGAASAACFYAPFKQVKpWSWETMWSlGGlVSWLILPWTlShLLLPDFWtYYGpFsluTLLPVFLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIlGTLMTPIlpGpFDVLltT.GGRMTLLGVFVALIGVuIVohAG.LKERtMGIpAEEFNLKKGLlLAVMCGIFSAGMSFAMsAAKPMHEAAuALGlssLYVALPSYVlIMGGGAllNLuaCFIRLAplpNLSlKADFSlA+PLlIoNILhSALuGLMWYLQFFFYAWGHA+IPtQYDYMSWMLHMSFYVLCGGlVGLlLKEWKsus++PVAVLslGClVIIlAANIVGLGMAu	.....................................................MspAIhhGIhWHLIGAASAACFYAPFK+VKcWSWETMWSV.GGIVSWlILPWsISALL.LP......s...FWA...YYu.pFsl.S...TLLPV...FLFGAMWGIGNINYGLTMRYLGMSMGIGIAIGITLIVGTLMTPI......I........N.......G........N..F...D.V.L.Is..T.E.G..G..R...M.TLLGVhVALIGVGI.VTRA..GQLK.....E...R.K.M.........G.....I.....K.......A......E......E......F.....NLK......K.....GLlLAVMCGIFSAGMSFAMNAAKP.M....HE.AA.A....A.L.......G.V.........D....P.....LYVALPSYVlIMGGGAllNL...GFC..FIRLAKVK..........sL.....S..l...KADFS.L.....AK....P....LI..IpNlLLSALGGLMWYLQFFFYAWGHARIP..AQ..YDYh..S..WMLHMSFYVLCGGlVGLVLKEWpNAGRRPVsVL..SLGCVV..IIlAANIVGlGMA........................................................................	0	23	47	59
+6207	PF06380	DUF1072		Protein of unknown function (DUF1072)	Moxon SJ	anon	Pfam-B_14592 (release 9.0)	Family	This family consists of several Barley yellow dwarf virus proteins of unknown function.	25.00	25.00	35.80	35.60	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.17	0.72	-4.29	8	42	2009-01-15 18:05:59	2003-06-10 12:58:32	6	1	7	0	0	41	0	38.70	54	93.28	CHANGED	MDDLHVIAVClLAhTVLoG....lGAVhGCChGChpss.sssps	MDDLHVIAVCl..LAhTVLoG....luAVlGCChGChps..su.......	0	0	0	0
+6208	PF06381	DUF1073		Protein of unknown function (DUF1073)	Moxon SJ	anon	Pfam-B_14928 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins. The function of this family is unknown.	26.40	26.40	26.40	28.10	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.80	0.70	-6.00	25	555	2009-01-15 18:05:59	2003-06-10 13:00:25	6	4	357	0	63	498	42	335.50	22	77.28	CHANGED	shsphphtuhYpsshls+phl-hsA-DhsRpshplputst....................cphpplcsphcclplppplp-slpasRLaGuuhllhtl..........cspphspPl..s.-plttuuhctlsslcthhlpss...hlspsshussaGcPphapl.s.st..............stcIHpSRllhh..........................ththPh..pht+.s.phaGpSllpp.lh-tlpshDsotsusupL.......lactplssl+ssshpplhsssp...splhcclshhpphcu.pulhllDs.......p-chpphssshu.GLc-llsphhptluusucIPhs+LhGpsPsGhNuoG-uDhcsYYDplpuhQ-pclpsslcpLhchlhhSthu........spslpa..cFsPLhpho-p-+A-ltpppu-uspthlss	.................................................................................................................h........thY.p.shhhtphl-..u-Dhh+psh..lputt.....................cphsthp.t.thpcl...p..lpptlhpslh....t...R..haGh.uhlhlhs..........pttshppPl.......p.c..th...hthchl.h.h...ph.h....lsssh..hhp.csh...u........sshs...p.sp.a.l.........................uhcIHcSRllhh..........................th.h.h.....p.s...hh...G.shlpp..lh-tL.pshssshsu.ssph....................lhpttlp..hhpsp........p.....hpphhs..tt..........t...................psltp.pl.phlpphp.sNp.G.hhhhss..........p-ph-shp.h......s.hu.sLc-h.l....s.httpluussphPhs+Laupp.spGhsusGcuDh..pNYYDhlpu....lQE....p.....hhps..sh....p+...lhchht..hs..............th.h..cFssLh.hoppppsphthphsphhpth...h...............................................................................	0	13	33	46
+6209	PF06382	DUF1074		Protein of unknown function (DUF1074)	Moxon SJ	anon	Pfam-B_14962 (release 9.0)	Family	This family consists of several proteins which appear to be specific to Drosophila melanogaster. The function of this family is unknown.	21.30	21.30	21.40	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.46	0.71	-4.31	3	76	2012-10-02 14:16:02	2003-06-10 13:06:12	6	4	15	0	41	84	4	103.50	23	66.99	CHANGED	Mussplptsp.hhst.lSluup...D.sspthsphhsh.IR.Rs.phstshhphtp.++htthGRKRGRKEYCPPIYKRQKVARVTNNGYLNFMTEYKKRFYGLSPQDMVHYAAKQWTQLSMAEKEAFKSKKPSTITLKSPAQYVACEMKSDVAGGQQSSCQRQSPSARLRESERRSSRSKTLCRSA	................................................t................................................................................................................s.................+p..p..p...u.....l..o.s....s.uYlNFlRpa....++....+....a..s....s..Lps.p-llppAA+tWspLoptcKpta...cp.................................................................hh...t............................................	0	7	7	30
+6211	PF06384	ICAT		Beta-catenin-interacting protein ICAT	Moxon SJ	anon	Pfam-B_15027 (release 9.0)	Family	This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions [1].	25.00	25.00	28.30	26.60	24.50	20.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.51	0.72	-4.20	8	132	2009-01-15 18:05:59	2003-06-10 13:28:22	6	4	77	3	83	108	0	76.50	47	44.90	CHANGED	MsRDltlGKlucDlYsQQKVEILhAL+KLGEpLoP-EEAFLsspAuAshSQFEKVop.slGuGcK..lhAhAuSplEsspK	.............MsR-hhsGKhsc-hYhQQKVElLhALRKLGppLTssEEtFLps...A..Gssh..SQ.hpplsp..s...lspGsc..lhAhup.pscctp....................	0	22	28	52
+6212	PF06385	Baculo_LEF-11		Baculovirus LEF-11 protein	Moxon SJ	anon	Pfam-B_15073 (release 9.0)	Family	This family consists of several Baculovirus LEF-11 proteins. The exact function of this family is unknown although it has been shown that LEF-11 is required for viral DNA replication during the infection cycle [1].	21.20	21.20	27.30	27.00	21.10	18.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.05	0.72	-3.89	24	60	2009-01-15 18:05:59	2003-06-10 13:31:41	7	1	58	0	0	54	1	94.50	40	79.17	CHANGED	CLTRS-VYAllREsINp+K+sh-scNVsAHl.-.ssFss.ppYIRssls+hhIhpucppp...+plshHtpRlpplFsLp.poLcpEYpts.hs+h.tspp	CLTRSEVYALlREsINp+K+shpscN.VsAHl.-..ssFps.ppYIRtNls+.hhllsucppp...+plshHtcRlsplFsLp..p...oLcpEYpps.ls+httt.p......	0	0	0	0
+6213	PF06386	GvpL_GvpF		Gas vesicle synthesis protein GvpL/GvpF	Moxon SJ	anon	Pfam-B_15376 (release 9.0)	Family	This family consists of several bacterial and archaeal gas vesicle synthesis protein (GvpL/GvpF) sequences. The exact function of this family is unknown.	23.60	23.60	24.20	24.20	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.62	0.70	-4.79	68	377	2009-01-15 18:05:59	2003-06-10 13:37:45	6	6	145	0	171	417	19	222.00	22	91.36	CHANGED	h.sp.ulYlYuIl...sssssh............t...............hsh.Glssss..Vhs....l..phssluAlVSssstsp...pstccsl...........hsHppVlcplhcp.s..slLPh+FGslh.ps.......tcs..lpphL.psttcphpptLsclpGphEhulKlhhsp.t..hhpplhtps.plpthptphttt..........s..stsh..pph...phsphlpptlppcppphspplhctLpslutpsp.pcs....................................hs-chllNsAaLVspsctspFsptlcplspphss...lslchoGPhPPYsFs..shph	......................................hYlYulh.........tt...................................th..Glssts...lhh...........l.......thssluAlVu.p.ss.tt....pstccpl................hsHppVlptlhtt..s...slLPh+FGslh..ts........pcs.lpphL.ptptpphtptLpplpG+sEhslKshhsp......tth..tts.th....tt..ttth.ttt..................s...sts.a.tph....phtphhtpthttptpphspplhptLpshu.psthpts.............................................spp.lhshuaLlsps......pt......s.t.Ftptlppltpphs...t......hplchsGPhsPYsFst.............................	0	67	130	164
+6214	PF06387	Calcyon		D1 dopamine receptor-interacting protein (calcyon)	Moxon SJ	anon	Pfam-B_15400 (release 9.0)	Family	This family consists of several  D1 dopamine receptor-interacting (calcyon) proteins.  D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling [1]. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) [2] and schizophrenia [3].	25.00	25.00	38.30	38.20	22.10	21.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.03	0.71	-4.92	3	132	2009-01-15 18:05:59	2003-06-10 13:45:12	6	2	41	0	72	117	0	169.40	55	98.17	CHANGED	MVKLGsNFuEKGuKpPulEDG..FDTVPLITPLDVNQLQhusPDKVVVKT+TEYQP-p+sKGKtRsPpIAEFTVs.p.t.scRh.solLVuFALAFLuCVVFLVVYKAapYD+.oCPDGFVLKHKpCIPtoLEuYYoEQDPSuRc+FYTVIuHYsLAKQSsTRuluPWhSuhuttK................................sh+EsEsPcKuu	............MVKLGsNhu-KssKtPss.....EDG..FpTlPLITPL-VspLQhPsP-..KVl.V.K.T+TEYps-pK.KGKhRsPKIAEFTls...t.sc.+h.solLlhhALAFLsClVFLVVYKsapYD+.uCP-GFVhK......pppCIPtuL-uYYopQ....D.ssuR....p+....FYTVIs..HYslAKQohoRuluPWhos.hut.p................................s.pEscsspp..u...................................	0	6	9	25
+6215	PF06388	DUF1075		Protein of unknown function (DUF1075)	Moxon SJ	anon	Pfam-B_14186 (release 9.0)	Family	This family consists of several eukaryotic proteins of unknown function.	25.00	25.00	25.20	27.90	20.40	24.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.86	0.71	-4.54	12	137	2009-01-15 18:05:59	2003-06-11 11:03:00	6	1	80	0	83	122	0	130.30	34	90.73	CHANGED	thGphhR.h......Ruhuos.phpc..............tt.stpsPtus...pph.ppsst.++Psph-K+hLlWoGRaKo.-EIPphVS.EMl-suRNKhRVKlsYlMIuLTlluChh.MllSGK+AscR+ESlsphNL-h+s+apEt........uhpupuc	...................................................................t..................................................tp......tsts....spt.h.......pclsh...++Posa-KKlLlWoGRFKpt--IPph..lS...EMl-sA+NKhR...VKlsYlMIuLTllGChh.hlhpGK+AspRp..E...olsphNlc++tch+..Ect..............t.......................................	0	17	23	49
+6216	PF06389	Filo_VP24	Filovirus_VP24; 	Filovirus membrane-associated protein VP24	Moxon SJ	anon	Pfam-B_15734 (release 9.0)	Family	This family consists of several membrane-associated protein VP24 sequences from a variety of Ebola and Marburg viruses. The VP24 protein of Ebola virus is believed to be a secondary matrix protein and minor component of virions. VP24 possesses structural features commonly associated with viral matrix proteins and that VP24 may have a role in virus assembly and budding [1].	25.00	25.00	333.70	333.60	20.20	19.30	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.75	0.70	-5.16	3	32	2009-01-15 18:05:59	2003-06-11 11:17:39	6	1	20	4	0	28	0	252.00	62	100.00	CHANGED	MAKATGRYNLVsPK+-hEKGVl..FSDLCNFLlTPTVQGWKVYWAGlEFDVsQKGMTLLsRLKoNDFAPAWAMTRNLFPHLFKNPpSsIQoPIWALRVILAAGLpDQLLDHSLIEPLoGALsLISDWLLTToToHFNlRTppVKDQLShRMLSLIRSNIlNFINKL-TLHVVNY+GLLSSIEIGTooasIIITRTNMGFLVEVQEPDKSAM..-o++PGPVKFSLLHESsLKPaopscpSuhpSLIMEFNSpLAI	MAchosRYNL..PppshEKuls..Lsshspalhp.oltGWpVhWush.FclsppGMsLLH+LKoN.hsPtWp.TRNLFsHLFpNPpSTI.pPhhALRllLusuLpDQ.LpQSLI.shpuhlphlS-WLLhpsTothplpsphlt..Lo.cMhpllhuslhpFhNKL.sLHVVN.pGh.SSIEIthosppIIITRsNMGFLVEVpc.Dhpsh..pohhstsVhFuLltEusL+taoQhppup..sLh..hNSplAI	1	0	0	0
+6217	PF06390	NESP55		Neuroendocrine-specific golgi protein P55 (NESP55)	Moxon SJ	anon	Pfam-B_16185 (release 9.0)	Family	This family consists of several mammalian neuroendocrine-specific golgi protein P55 (NESP55) sequences. NESP55 is a novel member of the chromogranin family and is a soluble, acidic, heat-stable secretory protein that is expressed exclusively in endocrine and nervous tissues, although less widely than chromogranins [1].	22.60	22.60	22.80	22.70	22.30	22.50	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.00	2	34	2009-01-15 18:05:59	2003-06-11 11:26:26	7	6	21	0	16	42	3	183.70	46	67.10	CHANGED	MDRRSRsQ.hRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALAoSssRAQQR.AAQRRoFLNAHHRS.....AAQVhPEs..sESDHEcp-hEPpL..PEC.EYpp--a-hE..SETEsES-IESETEh....ETEs-TAPTTEPETEPEDE.G...P+tsTFpQSLTpRLpAL+LpSsDASPpRA.PoTQEsESsppGEEPp....DpDPRDPEEp.E.+cEEppQ.+RCKs++Ps.RRD.SPESPs++GsIPIRRH	....................................................................................................................................................s.sp...spSDp-pp..phc.pL..sEs..-ap.p-h-hE..oETEsES-lEoET-..h....ETEs-Tt.PtTEPETE..PED-pG....P...+.tsTF......sQ..SLTpRLpAL+lp.SsDsp.pps.PosQpspssppGEE.p..P....pD.+sPEEp..-.+.p.....pQ.+RCKs+.+.s..RRD.SPESPs++GPIPIRRH...........................................................................	1	1	4	7
+6219	PF06391	MAT1		CDK-activating kinase assembly factor MAT1	Finn RD	anon	Pfam-B_16773 (release 9.0)	Family	MAT1 is an assembly/targeting factor for cyclin-dependent kinase-activating kinase (CAK), which interacts with the transcription factor TFIIH [1].  The domain found to the N-terminal side of this domain is a C3HC4 RING finger [1].	25.00	25.00	27.00	27.00	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.40	0.71	-4.73	6	318	2009-01-15 18:05:59	2003-07-03 16:31:22	8	7	278	1	239	314	1	168.20	31	55.13	CHANGED	LRKspFRsQlFEDspl-KEV-IRK+lhKIaNKpp-DFs.uL+EYNDYLEElEpIlaNLspslDl-pTccKlctYcKpNK-sIt+N+t+hssEQc.LEptLchE+cpcpc+R.thpp-Epppcht.KcpsKppllD-LpoSshssshlls.p+Ksps.hphEtthcK.cph+psshssuh+pu...phshsslp+lcEthasapPlp	...............LR+spF+hQhF-D.tV-KEV-IR+RVhpl.aNKp--DF....s.oLc.-.YNDYLE..c.......l..E-I..laN.Lss...s..l..D...l..t...p..T...ctclp..pYpp-Np.p.I.t.pNp.t.+.h..........pp.-ppt........hp.ph.ph.Epp.t...p..p+..+...tp...tptpph..t.tt+pthlspLt..........t.u.....p..........s...t.hlt...t.ttt.....t.p.................................................................................h............................................................	0	76	130	197
+6220	PF06392	Asr		Acid shock protein repeat 	Finn RD	anon	Pfam-B_20230 (release 9.0)	Repeat	The Asr protein is synthesised as a precursor and the cleavage is essential for moderate to high acid tolerance [1].	21.00	21.00	21.10	21.00	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.33	0.72	-6.55	0.72	-3.57	8	470	2009-01-15 18:05:59	2003-07-03 16:34:35	6	3	450	0	18	119	1	19.30	85	18.79	CHANGED	HHKKQH....KsAsEQKAQAAKK	...HH.KKQH......KAAPAQKAQAAKK.	0	1	3	8
+6221	PF06393	BID		BH3 interacting domain (BID)	Finn RD	anon	Pfam-B_16321 (release 9.0)	Domain	BID is a member of the BCL-2 superfamily of proteins are  key regulators of programmed cell death, hence this family is related to Pfam:PF00452 .  BID is a pro-apoptotic member of the Bcl-2 superfamily and as such posses the ability to target intracellular membranes and contains the BH3 death domain. The activity of BID is regulated by a Caspase 8-mediated cleavage event, exposing  the BH3 domain and significantly changing the surface  charge and hydrophobicity, which causes a change of  cellular localisation [1].	25.00	25.00	27.20	48.50	24.30	19.80	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.28	0.71	-4.95	7	65	2009-01-15 18:05:59	2003-07-03 16:42:05	6	2	36	5	27	64	0	163.70	51	94.68	CHANGED	M-.cV.sNGs....-phpphLlhuFLp...psscspFpcELpsLupE..LPs...th.tp..sELQTDGNRsu+..hpsthEs.DuEspE-llRpIAtpLAphGDcL-+p..I+PtlVsuLssphhNpoLsEE-hppsLAsslppLhpohPsDhEpEKshLllsMLLsKKlAspsPSLL+cVF+TTVsFIsQNhhsYlcpLsRp..-	......................ts-phTsLLlauFLp...ssssspFpcELcsLGpE.......Lss......hpt......-ELQTDGNRsS+.....hhtchEs.DSEsQ.......E-..llppIAtpLAplGDph-+u..I.PtLVssLAhQhhNsshSEEDRpppLAsAlEplh..Qsh..Pt..DhEpEKshLlLuhLLAKKVAsHoPSLLRcVF+TTVNFINQNLhsYlRsLsRN...................	0	1	2	7
+6222	PF06394	Pepsin-I3		Pepsin inhibitor-3-like repeated domain	Finn RD	anon	Pfam-B_13438 (release 9.0)	Domain	Pepsin inhibitor-3 consisting of two domains, each comprising an antiparallel beta-sheet flanked by  an alpha-helix. In the enzyme-inhibitor complex, the  N-terminal beta-strand of PI-3 pairs with one strand  of the active site flap region of pepsin [1]. The two domains are tandem repeats of sequence, and has therefore been termed repeated domain.	20.60	20.60	21.00	21.20	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.49	0.72	-4.32	13	63	2009-09-11 00:18:44	2003-07-03 16:51:00	8	2	18	2	35	64	0	70.30	29	53.54	CHANGED	P+ss+p.oFsThssT.sthhhsGChVpsN+lYlsstalRDLTssEtpELpsFcpchssYpstlppplppphpsLhus	....................p..sFss.hsso.s.hhhsGChVpsN+lYssuhhlR-LTspEhpELppappchstYpp.lppthppphpsh............................	0	14	18	35
+6223	PF06395	CDC24		CDC24 Calponin	Wood V, Studholme D	anon	Pfam-B_32837 (release 8.0)	Domain	Is a calponin homology domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.67	0.72	-3.92	17	130	2012-10-03 10:10:54	2003-07-03 16:58:00	6	10	124	0	99	201	1	89.40	42	9.83	CHANGED	DPVTpLWphFppGsPLChlFNslpP..cp.LsV.......ssss-h+hCKtulYcFlhusKpcLsass--hFsISDlaussTsshlKVlpVlsplL	.........DPVspLWphhRpGhPLhhlaNulp.P.....p.p...L.s.l........................ssss-t.+..tsKtu.lacFl.AChp....c...L.s....a.ssp......-hFhIoDL.a...u.s..s.ToGFVKVlpsVsplL.................	0	26	55	87
+6224	PF06396	AGTRAP		Angiotensin II, type I receptor-associated protein (AGTRAP)	Moxon SJ	anon	Pfam-B_15509 (release 9.0)	Family	This family consists of several angiotensin II, type I receptor-associated protein (AGTRAP) sequences. AGTRAP is known to interact specifically with the carboxyl-terminal cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to regulate different aspects of AT(1) receptor physiology [1,2]. The function of this family is unclear.	25.00	25.00	26.50	26.00	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.10	0.71	-4.55	6	84	2009-01-15 18:05:59	2003-07-03 17:24:07	6	4	70	0	53	93	0	144.00	36	83.59	CHANGED	MELPAVNLKlIlhVHWLLToauCls..hsGuYuasNFsILAhGVWAlAQRDSIDAIpMFLsGLluTIFhDllhIuIaaspss.......ltDhhRFSuGMAIlsLlLKPlSChhlYHMaRERGGph.htpGFlGsSp-R.SSYQsIDu.-sPADPhss.ps.u.ss.RGY	.......................t.PhlplKsIhhlHalLsoWuhl...s....hsuuYtasNFslLshulWAltp+..DS.l-Alph.hLs.hhshoIhhDIlplulaa.sp.hs............h..tsh.+FusuhuIlsLlL+.PlSshhlY+hapcR....GGph.......h....s.h..t...ssppp.puYpsIDp........P.tt...................................................................	0	17	20	34
+6225	PF06397	Desulfoferrod_N		Desulfoferrodoxin, N-terminal domain	Finn RD	anon	Pfam-B_11142 (release 9.0)	Domain	Most members of this family are small (approximately 36 amino acids) proteins that from homodimeric complexes. Each subunit contains a high-spin iron atom tetrahedrally bound to four cysteinyl sulphur atoms This family has a similar fold to the rubredoxin metal binding domain [1]. It is also found as the N-terminal domain of desulfoferrodoxin, see (Pfam:PF01880).	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.95	0.72	-4.56	8	428	2012-10-03 19:45:42	2003-07-04 09:46:30	7	6	397	31	132	306	13	35.50	48	24.00	CHANGED	scphpVYKCplCGNIVEVLcsGGGpLVCCGcPMcLh	.......h...hchYKCppCGNl.V.E.VhpsG.GG.p..LsCCGc.Mch.....	0	65	116	129
+6226	PF06398	Pex24p		Integral peroxisomal membrane peroxin	Wood V, Studholme DJ	anon	Pfam-B_56111 (release 8.0)	Family	Peroxisomes play diverse roles in the cell, compartmentalising many activities related to lipid metabolism and functioning in the decomposition of toxic hydrogen peroxide. Sequence similarity was identified between two hypothetical proteins and the peroxin integral membrane protein Pex24p [1].	24.50	24.50	24.60	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.55	0.70	-5.66	54	690	2012-10-01 21:10:52	2003-07-04 09:52:51	6	64	241	0	464	811	3	261.70	22	35.45	CHANGED	s.hosslLsssssplsppLuhhasal...scllpllTWossshhhohLllhsahslh.Yh..............thl.h.hshllhslhh.uhlaha....ts.h..............................................................................tp.pppPoLc......................................................-llhsLp...............slps+sshllpshstls.hh.........hpspsloshlFhhlhloslhlhls........hhllsh..+hlhlhsG.shlloaHsphpcshtphh...............hlsuhchp.............................................................hp....phh.shhpp..chh......h.ps.ps.p......................hph.laE.QR+h.luh...uWos.hhos-chshs.......sc...thsp.Ps..........................h-chp.Pp.....................sWcWs-..........pcWclDhsspthlp............sppc................GWlY..........................................ss...appsph.pDuhscasRRRRWhR	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hph.tlaENQR....h.....h...s...........sW.s..s........t....hh...s...-.ch.....sao..............st...ttpp.................................................................hcsh.p..h.Pp......................tWcW.s..............................cWplDh...s..t.hh..............................................................................ptpt......................................GWhYs...............................................................sh..........t..p.p....t...tcph.p.....ph.sRRR+WhR....................................................................................................	0	129	242	373
+6227	PF06399	GFRP		GTP cyclohydrolase I feedback regulatory protein (GFRP)	Finn RD	anon	Pfam-B_63435 (release 9.0)	Domain	Tetrahydrobiopterin, the cofactor required for hydroxylation  of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism  is mediated by the regulatory subunit called GTP cyclohydrolase  I feedback regulatory protein (GFRP) [1].	25.00	25.00	28.20	32.70	23.90	23.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.80	0.72	-4.39	4	69	2009-01-15 18:05:59	2003-07-04 10:35:58	8	1	53	35	39	61	0	80.00	67	93.65	CHANGED	PYlLISTQIRhEsGPThVGDEaSDPpLMshLsAcKhpsLGNNFpEYaVc-PPRlVLsKL-+lGYRVlSMTGVGQTLVWCLHKE	......PYlLISTQIRhEsGPTMVGDEpSDPcLMpaLGApKpssLGNNF.EYaVsDPPRlVLDKLE+pGFRVlSMTGVGQ..TLVWCLHKE.........	0	10	13	22
+6228	PF06400	Alpha-2-MRAP_N		Alpha-2-macroglobulin RAP, N-terminal domain	Finn RD	anon	Pfam-B_44514 (release 9.0)	Domain	The alpha-2-macroglobulin receptor-associated protein (RAP)  is a intracellular glycoprotein that binds to the 2-macroglobulin  receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of  all currently known ligands of these receptors [1].  The N-terminal domain is predominately alpha helical [1]. Two different studies have provided conflicted domain boundaries [2,3].	27.30	27.30	27.40	44.40	26.40	27.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.51	0.71	-4.44	10	108	2009-01-15 18:05:59	2003-07-04 12:32:49	6	3	73	7	51	104	0	113.90	50	33.65	CHANGED	lsLl.hlllhhsshssuspuuKYSREsN.........EshssscRcsscEFRMsKLNQlWEKAQRL+LoslKLs-LHoDLKIQEKDELsWKK.LKs-GhDcDGEKEA+LRRsLslIho+YGL....DG+KDscplc	.....................h....h.hhhh..sstttusKYS+EtN..........p...s.ssh+.p.....tp.FRMtKLNQlWEKApR.h....+..L.osV+Lu.-LHuDLKIQE+DElsWKK.LKs-GLDc....DGEKEA+LpRsLs...VILu+YGL....DG++Dsp.l.p..............	0	12	15	32
+6229	PF06401	Alpha-2-MRAP_C		Alpha-2-macroglobulin RAP, C-terminal domain 	Finn RD	anon	Pfam-B_44514 (release 9.0)	Domain	The alpha-2-macroglobulin receptor-associated protein (RAP)  is a intracellular glycoprotein that binds to the 2-macroglobulin  receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of  all currently known ligands of these receptors [1].   Two different studies have provided conflicted domain boundaries [2,3].	21.80	21.80	22.00	21.90	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.78	0.70	-4.48	11	128	2009-09-10 22:25:31	2003-07-04 12:54:44	6	3	87	4	66	123	1	200.30	44	62.32	CHANGED	-hhcDP+L-KLWpKA+TSGKFScEEL-sLhREFpHHK-KIcEYpsLL-olu+sE..................................EhacNlIsPp-.sshKppsLps+Hs-LK-+hRsIspGaDRLR+loHpGasotpEFpEPRV.-LW-hApsuNFTccEL-Sh+EEL+HFEsKlEKHpHYQcQLElSHpKLKHhtthGDp-Hls+spE+ashLE-+hKEhGYKVKKHhQDLouRIS..th+HNEL	................................hhcD.+LpKLW.pKAcsSGKFSsEELcpLhcEF.HHc-KlcEYpsLL-slu+s-...............................-hpc.NsIs.sp........-....sthKt.pslps+...cs..-L.K-+hRsIppGhDRL.+.+.lopp.Ga.s.stpEFpEPRVh-LWclA.p.su.N.FTpcEL-.Sh.+.....EEL+HFEuKl-KHpHapcpLclu+pKh+....tthGDtE+lscppE+ashLE-+hK..cl.uhKV+KhhpDLps+I...hh+HsEL..................................	0	16	21	44
+6231	PF06403	Lamprin		Lamprin	Moxon SJ	anon	Pfam-B_15493 (release 9.0)	Family	This family consists of several lamprin proteins from the Sea lamprey Petromyzon marinus. Lamprin, an insoluble non-collagen, non-elastin protein, is the major connective tissue component of the fibrillar extracellular matrix of lamprey annular cartilage. Although not generally homologous to any other protein, soluble lamprins contain a tandemly repeated peptide sequence (GGLGY) which is present in both silkmoth chorion proteins and spider dragline silk. Strong homologies to this repeat sequence are also present in several mammalian and avian elastins. It is thought that these proteins share a structural motif which promotes self-aggregation and fibril formation in proteins through interdigitation of hydrophobic side chains in beta-sheet/beta-turn structures, a motif that has been preserved in recognisable form over several hundred million years of evolution [1].	25.00	25.00	27.60	27.40	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.23	0.71	-4.43	2	8	2009-01-15 18:05:59	2003-07-07 09:25:55	6	1	2	0	1	7	0	122.90	78	98.60	CHANGED	MAAshQALLVlALLHLATATPVlsKppVSThSTGaLGHPVGGLGYGGLGYGGLGhuGLGVAGLGYGGLGYPGAALGGsYTHHAA...................LGGLGYPLGIGAGVVAPHVVpuKlAAPLAPVVAAI	...........................MAAshQALLVlALLHLATATPVlsKppVSThSTGaLGHPV.GGLGYGGLGYG..GLGhuGLGVAGL.GYGGLGYPGAALGGsYTHHAA...................LGGLGYPLGIGAGVVAPHVVpuKlAAPLAPVVAAI.........	0	1	1	1
+6232	PF06404	PSK		Phytosulfokine precursor protein (PSK)	Moxon SJ	anon	Pfam-B_16071 (release 9.0)	Family	This family consists of several plant specific phytosulfokine precursor proteins. Phytosulfokines, are active as either a pentapeptide or a C-terminally truncated tetrapeptide. These compounds were first isolated because of their ability to stimulate cell division in somatic embryo cultures of Asparagus officinalis [1].	25.00	25.00	38.10	34.70	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.46	0.72	-3.21	39	143	2009-01-15 18:05:59	2003-07-07 09:27:33	7	2	32	0	69	132	0	80.10	35	86.39	CHANGED	lLLL.h.s.sh...stAARs....tPs.tspp.tt..........stsppscttt...................................sCc...t.ts-EE.C.LhRRsLs.AHhDYIYTQc+ps	...........................................h.LlL.h...ph....stAAR........Ps.tttp..t....................ttttsptt...................................thh..ttE.............................sC-...t.ts-.EE...C.L.hRRsLs.AHlDYIYTQc+p....	0	8	37	52
+6233	PF06405	RCC_reductase		Red chlorophyll catabolite reductase (RCC reductase)	Moxon SJ	anon	Pfam-B_15577 (release 9.0)	Family	This family consists of several red chlorophyll catabolite reductase (RCC reductase) proteins. Red chlorophyll catabolite (RCC) reductase (RCCR) and pheophorbide (Pheide) a oxygenase (PaO) catalyse the key reaction of chlorophyll catabolism, porphyrin macrocycle cleavage of Pheide a to a primary fluorescent catabolite (pFCC) [1]. 	24.60	24.60	25.30	25.30	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.55	0.70	-5.44	8	86	2012-09-25 10:41:40	2003-07-07 09:28:14	6	2	40	10	34	91	13	202.40	42	84.35	CHANGED	AHRElMlsLsuplEsRLGup..LLPsslPsDVp.FcN..tuGsApGSLclRSGspuSs.....................................IDFhLtSWlHCclP..tGGAlNITSLslaLNuSTDAPHFlhEhIQuSPTSLlllLDLlPRKDLsLHPDYLccYYEsTtLD.+pRppltcL.PcspPYhSsSLalRulhSPTAlhsoI-ssp..utttplEEIlpsclussAK-VLplWL-pCs..ssscE...ls-sERpthtKRDpllRpKoIElDLsuslP.RhFGt-VAsRVltsIRcAF	.................................t.h..h.t...tpht....hLPsslPsDVp.aps...s..Gs...AtuSLclRsGttuS......................................IDFhltSWlHsclP..tuuulsITol.saLNuSTcAPpFlhEhIQuossSLlllLDL.sRKDLsLpP-YLccYYpsTtLD...ppRppl.cl..PpspPYhSsSLalRSshSPTAlhhplts.tt.......tth-pllp..ltshu.thh.thWlpths..tttt......h.t.tpt..h.tRD..hppt.hEhs.s.phs.phFs.thsspllt.h.t.........................................	0	4	18	25
+6234	PF06406	StbA		StbA protein	Moxon SJ	anon	Pfam-B_12747 (release 9.0)	Family	This family consists of several bacterial StbA plasmid stability proteins [1].	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.76	0.70	-5.49	7	732	2012-10-02 23:34:14	2003-07-07 09:29:06	6	2	457	34	70	604	104	269.10	33	89.60	CHANGED	M+lhlDDGSTNIKLAWh.E.cGcl+shlSsNSFK.-Wsssh...sst...pshNY.lDG.c+YoaD.lSssulhTTcspYQYSDVNllAlHHALhpSGLtPQsV-lsVTLPloEaaDpssQsNhtNIpRKKsNlhR.lp..lps.u-sFsI+pVsVhPESlPAuFpsLtt..lsphES.LIlDLGGTTLDluplhGphsGISclasssplGVSllTcuVhpsLsh.ssocsSpahADclIppRpDpsaLpphIpstschstlhpslpct.cpLtp+VhpslupFsshs+.VhlVGGGApLltsAlKpthth.st+hhhsssPQFsLV.uhhth	.......................................................................................................................................l.hDDGopshKl.h..p..ttt.hh...lo.N....S.Fp.t.at......h....t.....tshNY...l.s..s.....pasa..c.h...o.....p.......l.Ts..ph..t..a...QYsp..hNhl..AlpHALh.p..o.Gl.....t.s.p....Vs..lsVT.LPlo...-a.hs...p.ps.Q.s.tp.I..pR...KptNlh...+..lp.........hpt.....up.....s.F...s...I...c...sV...pVh..PE...Sl.PA..s..ap.h.Ltp...........hs.....t....h....-....p.....h...L.....I.......lDlGGTTLD..l..u..h..l....t..u..p..hs..s.....l.o...p..s...h..s..ss...p...lG........V.S.hhsculhps.h........tt....s....s.............h...c...s..S.....p...hh...A.spl.............Ip..p.R......p-....t...........s...a..l..p...p.h.....Ip...s...t.......s.p...hs...........tlh.s.s...I....p....pt.....cpLtp...c.Vhp....s....l......s.....p....F.....p...s.......h.s+....V.......hllGGGA..tl..l.....ts.ul.+pthth....ttp.hhh.tssQhsLs.uhh............................................................................................................................................................	3	21	40	57
+6235	PF06407	BDV_P40		Borna disease virus P40 protein	Moxon SJ	anon	Pfam-B_15995 (release 9.0)	Family	This family consists of several Borna disease virus P40 proteins. Borna disease (BD) is a persistent viral infection of the central nervous system caused by the single-negative-strand, nonsegmented RNA Borna disease virus (BDV). P40 is known to be a nucleoprotein [1].	25.00	25.00	53.20	53.20	18.70	17.70	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.29	0.70	-5.60	3	171	2009-09-10 21:38:57	2003-07-07 09:32:44	6	1	17	2	2	111	0	184.30	67	98.87	CHANGED	MPPKRRLVDDADAMEDQDLYEPPASLPKLPGKFLQYTVGGSDPHPGIGHEKDIRQNAVALLDQSRRDMFHTVTPSLVFLCLLIPGLHAAFVHGGVPRESYLSTPVTRGEQTVVKTAKFYGEKTTQRDLTELEISSIFSHCCSLLIGVVIGSSSKIKAGAEQIKKRFKTMMAALNRPSHGETATLLQMFNPHEAIDWINGQPWVGSFVLSLLTTDFESPGKEFMDQIKLVASYAQMTTYTTIKEYLAECMDATLTIPVVAYEIRDFLEVSAKLKEEHADLFPFLGAIRHPDAIKLAPRSFPNLASAAFYWSKKENPTMAGYRASTIQPGASVKETQLARYRRREISRGEDGAELSGEISAIMKMIGVTGLN	..........................................................................................................................................................................................................................PHEAIDWINuQPWVGSFVLuLLTTDFESPGKEFMDQIKLVAuaAQMTTYTTIKEYLsECMDATLTIPsVAhEI+-FL-sosKLKtEHuDhF.aLGAIRHsDAIKLAPRsFPNLASAAFYWSKK.............................................................................................	0	2	2	2
+6237	PF06409	NPIP		Nuclear pore complex interacting protein (NPIP)	Moxon SJ	anon	Pfam-B_16418 (release 9.0)	Family	This family consists of a series of primate specific nuclear pore complex interacting protein (NPIP) sequences. The function of this family is unknown but is well conserved from African apes to humans [1].	27.00	27.00	27.30	27.40	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.83	0.70	-5.65	5	342	2009-09-13 05:25:39	2003-07-07 09:37:51	6	5	26	0	83	271	0	107.00	34	36.57	CHANGED	VINTLuDHcHsGscFpGs......PWlhIIIsFLRpYKhsIhLCTohLsVSFLKTIFhScNGHDGSTDVQQRAWRSNRpRQcG.................NKIGLKDVITLWRHVETKVRAKI+KhKVTTKIN+HDKINGKRKTAKcH..LRKLSMKECEHAEKERQVSEAEENGKLDMKEIHTYKKMFQRAQELRRRAEDYHKCKIPPSARKPLCNWVRMAAA..EHRHSSGLPYWPYLTAETLKNRMGHQPPPPTQQHSIsDNSLSLKTPP..ECLLpPL....PPSsDDNLKssP	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	69	69	71
+6239	PF06411	HdeA		HdeA/HdeB family	Finn RD, Bateman A	anon	Pfam-B_63431 (release 9.0)	Domain	HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localised in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS [1,2]. This family also contains HdeB [3].	21.90	21.90	21.90	22.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.26	0.72	-4.02	33	942	2009-09-11 09:58:26	2003-07-07 12:09:41	6	2	576	13	43	189	4	94.30	39	85.95	CHANGED	htlshhhhshsssshs.........ssu.ss.spss..........ssppMTCcEFlsLsspthssVshWhhshsp.phKssDhV..Dhppl-sl.sPpllchCKcsPppplh-h	...............................................hht...uhIhhGhlhhssl...........sNAtsA.tAs-..........sspshTCp-Fl....s....LssphhssVshWshs.ss.phKstD.sV..Dlpth-ss.sPtll-hC+psPQsslhc...................	0	8	19	28
+6240	PF06412	TraD		Conjugal transfer protein TraD	Moxon SJ	anon	Pfam-B_11863 (release 9.0)	Family	This family contains bacterial TraD conjugal transfer proteins [1].  Mutations in the TraD gene result in loss of transfer [2].	21.90	21.90	22.30	22.00	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.93	0.72	-4.38	53	460	2009-01-15 18:05:59	2003-07-07 13:19:58	6	4	282	0	117	388	14	64.10	29	63.06	CHANGED	hpsttR+ccTRchIpLGGLVlKAG.......Lst.-+uhlhGALl.hucphcsstt......pphapttGpphFptc	.................p..pR+tcTRchItLGuLVsKAs.......lcsh-+phlhGhLlshuchhptspt.......ttapttGpphhpt................	0	18	57	85
+6241	PF06413	Neugrin		Neugrin	Moxon SJ	anon	Pfam-B_11274 (release 9.0)	Family	This family consists of several mouse and human neugrin proteins. Neugrin and m-neugrin are mainly expressed in neurons in the nervous system, and are thought to play an important role in the process of neuronal differentiation [1].	21.80	21.80	22.60	21.90	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.45	0.70	-4.53	6	219	2012-10-04 14:01:12	2003-07-07 13:23:26	6	6	192	0	152	221	0	144.00	29	49.44	CHANGED	MEssGAP.RpLTW-AhEQIRYL+cEFPEpWoVPRLAEGFsVSTDVIRRVLKSKFlPolEpKLKQDtKV...........hK+hu.s..h..L.usususKhLsuGp...........SlSsuLLhPGcEsuS.tspsHShALKshcpp.ppsssstppps+sKplQsLc-h.shVssssshGc.tp....ssoDspttccthsGsL.SDpcLEELptsEhGc...ss+VVQRGREFFDSNGNFLYRI	...............tth.....sP.+.+Lo.-sh-tIRhL+pp.P-paosspLA-pFplSPEsIR.RILKS.KWp.P.o.......t...-....p.c......c..ptt.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	40	74	118
+6242	PF06414	Zeta_toxin		Zeta toxin	Moxon SJ	anon	Pfam-B_12374 (release 9.0)	Family	This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.02	0.71	-5.22	40	1247	2012-10-05 12:31:09	2003-07-07 13:29:24	7	17	949	8	252	6029	2517	168.70	21	56.57	CHANGED	hsphhss........pt...sp.cpPhullluGQPGAGKopltcthhpph......psshlpl-sD-hRpha................PpYpth.p...t..s.psuphsptt....ushhs-plhspAhcp+hslll-uThpss-hspc.hhcpL+.....c.tGYplplhhlsss.chShttstpRappp...t...............G.Rhlstctactsa.....psh.cslpplcppt..hhsthh.lh...........spss.splYcsphs	..........................................p................ppPh.h.hl.l.uGtsGAGK.oolh....p..h.h.hp.p.h.............tsshl....h...I.........s.....u.....D..p.....h......+.p.....h..............................................................s.p..a.....t......................p.....s..p....h...s..p........................u..s.....p....h..s....p...p....h...l....p...p......h.....h...p...p.....t...h......s....h.l....h..E....s....T.....h....p......s..h....s.......h.........p......p..hhphh+.................................p...tG...Y.p...l.p...l..h.h...l.s..s........p......t...lu.h....p....s.h.Rhtp...............................................................u.+hs.sp..p.thp...hh.....................tt.h..psh.t.th............p.h...lh...........p............t................................................................................................................................................	0	67	159	208
+6243	PF06415	iPGM_N		BPG-independent PGAM N-terminus (iPGM_N)	Moxon SJ	anon	Pfam-B_1338 (release 10.0)	Domain	This family represents the N-terminal region of the 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (or phosphoglyceromutase or BPG-independent PGAM) protein (EC:5.4.2.1). The family is found in conjunction with Pfam:PF01676 (located in the C-terminal region of the protein).	21.20	21.20	21.20	21.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.45	0.70	-5.01	35	2910	2012-10-03 05:58:16	2003-07-07 13:45:27	8	9	2783	9	666	2087	892	216.40	43	44.36	CHANGED	IspuIc-GcFapN.slhpshscscpsssslHlhGLlSsGGVHSHhcHLhALlclAtc+Glc+ValHsFhDGRDVsPpSutsalcclpshhpc.huhG...cIATluGRYY.AMDR.DpRW-RlcpAYcshs...Gcup.phpsulpslpsu...YspshoDEFlhPolIss...t.suslcDsDuVIFaNFRsDRARQlocshsppc.FcsFpRpph...pl.paVshTpY-sslss.slAF	......................IspuIc-GpFh.p.N.tsLhsAlcps+p.....s.s.p..s.lHlhGLlSsGGV.......HSH.cHlhAh.l-lAtcp.G..s..c..+.lYlHAFLDGRDssP+SAtshlcchppthsc......lGhG......clAolsGRYY.AMDR.DpR....W.-RVc..cAYchls..............u.........c.G..p......................p.s.s.o............Alpulpsu...............Y....s......c.......s................s.......DEFVpPsllts....................susl.....pD.GDulIFhNFRsDRA..Rplocshss.........t...........-...F............c.......s............Fp...............Rpph..................sl...pa.l.shTpYs.sslps..hha...............................	0	260	470	585
+6244	PF06416	DUF1076		Protein of unknown function (DUF1076)	Moxon SJ	anon	Pfam-B_2653 (release 9.0)	Family	This family consists of several hypothetical bacterial proteins exclusive to Escherichia coli and Salmonella typhi. The function of this family is unknown.	25.30	25.30	25.50	39.00	22.20	25.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.57	0.71	-4.38	12	614	2009-01-15 18:05:59	2003-07-07 14:06:50	7	1	106	2	3	296	0	106.30	47	63.59	CHANGED	M.pspupspppc...............s....lpsKIspssFsVsspchpCspptlpCPITLshPEcGVFV+NutsSplCoLaDpsAhocLlpcsuhHPLSREPlossMIlu+-cChFDts+tsFsIh	..........................p...pp...............tt.p.L.sKIppCsFsVs.pchpCspphlpCPITLs.PEcGVFl+NSpsSplCoLYDpsAhscLlccshsHPLSREPIosSMIVp+-pChFDsp+tsFllh........	0	0	0	3
+6245	PF06417	DUF1077		Protein of unknown function (DUF1077)	Moxon SJ	anon	Pfam-B_6645 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	25.00	25.00	43.10	38.10	22.10	21.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.61	0.71	-4.80	30	340	2009-01-15 18:05:59	2003-07-07 15:38:58	7	7	291	0	233	300	6	118.90	39	66.13	CHANGED	sppspppppppLthKKAW-lAluPhKslPMNlFMhYMoGNSlpIFPI.MhlhMhlhsPlKulho.ssssFcslcss....................plhhs+llYllhplhshul.........ulaKhpsMGLLPsssSDW.....Luappspph	..............ts...ptpppptLhhKKuW.-lAluPhK.plPMNhFMMYM.oG.NolpIFsI.MM.VhMhhhpPlpulhu.ssssFchhcss............s.............................phhh.+llYlhhplhslul.........ulaKhpuMGLLPTptSDWLua.t...t............................	0	85	134	195
+6246	PF06418	CTP_synth_N		CTP synthase N-terminus	Moxon SJ	anon	Pfam-B_226 (release 10.0)	Family	This family consists of the N-terminal region of the CTP synthase protein (EC:6.3.4.2). This family is found in conjunction with Pfam:PF00117 located in the C-terminal region of the protein. CTP synthase catalyses the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position [1].	22.30	22.30	24.40	23.50	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.89	0.70	-5.31	98	5282	2012-10-05 12:31:09	2003-07-07 15:48:15	9	16	4818	13	1383	3730	3009	264.10	58	50.53	CHANGED	sKaIFVTGGVlSSLGKGlsuAS.lGtLLcsRGhcVohhKlDPYlNVDPGTMSPaQHGEVFVT-DG.............uETDLDLGHYERFlshsho..+psNlToG+.......IYpsVIpKER+G-YLGpTVQVIPHlTsEIKppIp.....ps.sp.............t...sDllIlEIGGTVGDIEShPFlEAlRQhph-h.GpcNshalHlTLVPalpsuGEhKTKPTQHSV+-LRslGIQPDlllsRo-cs.lscsh+cKIALFCsVspcsVIsshDlp.sIYcVPLhLccpGlsphlhccL.......pLs...tps.sh..scW	...........................................TKYIFVTGGVVSSLGKGIsAAS..........LutLLcsRG...Lp............VT.h.K....l....................D....PYINVDP...GTMS......P...a......QHGEVFVT-DG.............AETDLDLGHYERFl.c.hs.....ho..+psNlTTG+..........IYp..........s.V..l.cKERRG.D.YLGs..............T.V..Q.......VI.PHITspIK-+lhcsuct...............................t...sDVlIsE.........I.........GGTV.............GDIESLPFLEAlRQhph-l.........G.+..-sshalHlTLVPYl....t..uuGEh.......KTKPTQH.SVKE..............LRu.....lGIQPDl....LlsR..o..-.c.s....ls.p.sh+pKIAL.FCsVs.t.cuVIpshDsc.oIYclPhhL.ppQGlDphlsc+LpLs....s.psshspW..............................	0	458	871	1151
+6247	PF06419	COG6		Conserved oligomeric complex COG6	Wood V, Studholme D	anon	Pfam-B_10345 (release 8.0)	Domain	COG6 is a component of the conserved oligomeric golgi complex,  which is composed of eight different subunits and is required  for normal golgi morphology and localisation.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	618	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-13.04	0.70	-6.39	29	369	2012-10-03 17:31:52	2003-07-07 15:53:51	6	10	276	0	265	379	2	501.50	27	82.22	CHANGED	DuLptLsphshpNThpsRRpLRh-lc+cllcsNsphlc-FtpVscpLcclssslsplspsscphppplssspppTpsllp-sssLhpp.ccplchKpplLpuFps+FhLsptEhthLssstp......sls-cFFplLs+scpI+cDCchLL..us-..spphGLclM-psspplpsAhp+La+ah...Qcca+sL.....sh-ssph...sssl+cAlphLt-RPsLFpssLDpaspuRcpsLs-sFhsALTtsss.............ust.....+PIEhsAHDPlRYlGDMLAWlHSssVsE+EsLcuLFthpscph.cs.p..hp....................ctls-lls+.lpuluRsL+.RlEpllps.....cccslhhYclsNLLpFYpshFs+l.lsssS.....LlpslpsLpchuhppahshhpsplsslpss........ht.sssD..LtPPcaLt-hLppLpslhcs..hpsShss.............sscp............sphphllppsl-PhlphsppsuttLsshpp..............slahlNsLhhhcoslssasasp........c+lp.lpsplsphtspLhphQhphllppoGLsslhshlp.h.........................p.p.htslssh.hhp.psL.tpssppLscFLPoA.LhDhpssL.ppLpSsphspslsccusctFsc.aphlcthlhsstpt.......................hh.+sstclt.slL	..................................................t.Lst.hhtsohpsRRpLRtpl-cc.lt.stphlptFttlt...c......................p................Lcpltpplpthspsspp............hppplp.ss....p....tpTts.lltpsspLptp...ppplph+pplhpsFhpcFp.....LotpEhthLpss...................sl....sppFFpsLt+sppI+pcsc.hLL..ttp.....................ppphGl-l.M-phshh....ptuhp+Lh+Wh..........................ptchcsl...................s.-ssph.................sshlppuhp.hL.pc.R.P.sLa.p.sl-phupsRcpsl.ctFhpALTtuss..........................................st.............+PIEh..pu.HDPlRYlG..........DMLAWlHpshssE+EhlpsLh.....h.tst.p...................................................................................pthppllsc.hpuls+sl+.RlEpll.s................................p....s.lhhaplssLLtFYp.h....hpth..lttps...............L..hpsltphp..s.phahs.hp......phttl.tp.................................ss.D..L.Ps...l.phlt.Lhtlhts...hpsohh....................ttpp.......................................tph..llpthl-Phlphsp.t..u..tt...hts.p...................................................thahlNsh.hhpsslt.aphsp.............phhp.lpttlpt.hppLhp.php.llppsGLt.hhphlp.........................................tshsp...hp..tl..tth..phstaLs.ts.....hh..pl.thl.ssthhpplhppshp.hst.at.l.thlht..p....................................hh.hs..plt.h..............................................................................	1	104	152	220
+6248	PF06420	Mgm101p		Mitochondrial genome maintenance MGM101	Wood V, Studholme DJ	anon	Pfam-B_35151 (release 8.0)	Family	The mgm101 gene was identified as essential for maintenance of the mitochondrial genome in Saccharomyces cerevisiae [1]. Based on its DNA-binding activity, and experimental work with a temperature-sensitive mgm101 mutant, it has been proposed that the mgm101 gene product performs an essential function in the repair of oxidatively damaged mitochondrial DNA [2].	27.00	27.00	36.30	35.80	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.17	0.71	-4.93	27	148	2009-01-15 18:05:59	2003-07-07 15:57:53	7	2	140	0	116	150	1	168.10	61	59.67	CHANGED	lDWspSaaGLuppPFocEsuclLhsPlsspDlEIKPDGllYLPEIKYRRILN+AFGPGGWGLAPRG-olVs.....s+hVoREYALlspGRLVSlARGEQsY.F.sscuIPTAoEGCKSNALMRCCKDLGIASELWDPpFIRpFKpcaspEsasEHl...sTKKKKKlWh+K...ppphsYPaK	.....................................lDWopSaaGLuspPFscEssclLltPlsscDlEI.KPDGllYLPEIKYRRILN+AFGPGGWGLsPRuEolV.o......sKhVTREYALlspGR..........LVSlARGEQ-YF...u.cG...IPT..AoEGCKSNALMRCCKDLGIASELWDPpFIRcFKtpaspEsFVEHV...sTK+K+KlWhRK...-cplpYPaK............................	0	40	69	100
+6249	PF06421	LepA_C		GTP-binding protein LepA C-terminus	Moxon SJ	anon	Pfam-B_425 (release 10.0)	Family	This family consists of the C-terminal region of several pro- and eukaryotic GTP-binding LepA proteins [1].	22.00	22.00	23.00	23.70	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.35	0.72	-4.14	45	4879	2009-01-15 18:05:59	2003-07-07 15:58:45	7	24	4651	11	1211	3357	2420	106.40	65	17.86	CHANGED	lNG-hVDALShIVH+spAhp+GRplspKLK-lIPRQ.F-lsIQAuIGu..KIIARETIKAlRKs....VlAKCYGGDloRK+KLLEKQK-GKKRMKplGsVElPQEAFlulL+h	................lNG-pVDALShIVH+DpA.pRG+tls-KLK-LIPRQ.F-lsIQAAIGs...+IIARp.....TlKAlRKs....VL.....A.....K....CY..GGD.l.SRK+KLLEKQKcGKK..R..M..K..p..l.Gs...VElPQEAFlAlL+.......................	0	417	786	1029
+6250	PF06422	PDR_CDR		CDR ABC transporter	Gauthier C, Studholme DJ	anon	Pfam-B_1005 (release 8.0)	Family	Corresponds to a region of the PDR/CDR subgroup of ABC transporters comprising extracellular loop 3, transmembrane segment 6 and linker region.	20.50	20.50	20.60	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.33	0.72	-4.36	167	1227	2012-10-03 10:13:34	2003-07-07 15:59:49	7	44	184	0	900	1245	0	97.70	26	7.84	CHANGED	shlPs.Gs..sYt.shs.ssppsCu.ssGuhsGps.....hVsG-s.YlptuasYphuHhWR.....NaGIllAFhlhFhslhllssEhhpsspupG-sLlFpRuph.pt......................tttt.....sDtE	..................................hlPt..G..s...sYt...shs.....tppsCs..hsGuhs...Gp..s......hVsGc.s.YlptsasY............phuH..hWR......................NaGIlhuFhlh.Fhhhh.lls.s..Ehh....p...h....tts...t.u.p.h.lla.+sph.th....................ptt.............................	0	239	480	779
+6251	PF06423	GWT1		GWT1	Wood V, Studholme DJ	anon	Pfam-B_15982 (release 8.0)	Family	Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in eukaryotes. GWT1 is involved in GPI anchor biosynthesis; it is required for inositol acylation in yeast [1-2].	29.60	29.60	29.60	29.60	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.07	42	299	2009-01-15 18:05:59	2003-07-07 16:01:32	7	11	251	0	222	304	3	145.70	30	28.81	CHANGED	tNREGlhShh.GYlAIFLhGpsh.Ghhllspphsh.......................................ttthhphlhpLhhhshlhhhlhhls.......thshslSRRlANhsYVlWVsuhNsthLhhasll-phhhsshh.....................................sspllpAhNpNGLslFLlANlLT..GhVN	.........................................................tNREGlhShh.GYluIaLhGh...sh.Ghhlhspptp...........................................................................................................pphhphh..hpLhh.huhhhhhhhhlsp........shs.slSRRhANhsYll.WlhAhshh...hLhh...hh.lh-t...l...hh.sh.................................................................................sstllpAhNpNsLhhFLlANllT..GlVN.................................	0	72	114	179
+6252	PF06424	PRP1_N		PRP1 splicing factor, N-terminal	Wood V, Studholme DJ	anon	Pfam-B_6467 (release 8.0)	Domain	This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1 [1]. It is involved in    mRNA splicing and possibly also poly(A)and RNA nuclear export and cell cycle progression.	20.90	20.90	20.90	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.50	0.71	-3.83	33	327	2009-01-15 18:05:59	2003-07-07 16:04:43	7	42	271	0	240	327	4	141.10	45	16.43	CHANGED	sPsGYVuGlGRGATGFoTRuDhGsu+t.........................................pppp-cDsschs-............stst.uLFupst.h..Dc-DcEADcIYppIDc+MccRR+pc+Ep+pcp-hpchctpp.......PplppQFuDLKRsLusVo---WtsIPEsGDhTtK	..................................AP.sYVsGlGRGATGFTTRSDl..GPAR-uss..t.t...............................................tttppp.ppp-c-.-cchp-...............s.st..uLF.uss...Y...DcDD-EADtIYp.tlDc+..MDcRRKc+REtRp+pEhEcactpp..........PKIppQFuDLK.............RpLusVo--EWtsIPElGDhpt+............................	0	85	135	200
+6254	PF06426	SATase_N		Serine acetyltransferase, N-terminal 	Wilbrey A, Studholme DJ	anon	Pfam-B_1192 (release 8.0)	Domain	The N-terminal domain of serine acetyltransferase has a sequence that is conserved in plants [2] and bacteria [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.29	0.72	-3.78	111	1759	2009-01-15 18:05:59	2003-07-07 16:08:33	9	11	1568	37	424	1080	487	92.10	42	34.01	CHANGED	lWppl+pEAcpssppEPlLuualauoILpHsolcsALuapLusKLuss.phs..s.hLp-lhpcAhts.cP............plspusp..sDlhAlh-RDPACpp.ahpPlLaaKGFpAlQu	...........................................lWppI+tEActhsppEPhLuuFhauol.LpHpsLtsALuahLAs+....Lsss......h...s...u.......htlc-lhcc.shts...cP.................phhtsst..sDIpAVhpRDPAscp.aspPLLYhKGFHAlQs................................	0	116	251	340
+6255	PF06427	UDP-g_GGTase		UDP-glucose:Glycoprotein Glucosyltransferase	Studholme D, Wood V	anon	Pfam-B_4648 (release 8.0)	Family	The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase.	21.20	21.20	22.60	22.50	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.20	0.70	-5.03	20	379	2009-01-15 18:05:59	2003-07-07 16:09:48	6	11	262	0	258	355	5	194.50	35	14.04	CHANGED	SDhhhphsuhh...ush.ppcs.....Rhsh.phls.spposlpl..s.tppcs........shhclsAllDPlo+puQKlssllphLschl..slsl+lahNPps....phs-lPlKsFYRaVlp.sp.pF.sssGthss.PtAhFsslPsspLLThsl-sP-uWlVpshcu..paDLDNIhLpclsss..........................VsApYcLEplLlEGaspDhssssPP.RGLQLpLs..opssshhs..........DTIVMAN	....................................................................t...........Rhph.phhp...spao.slpl..s.....ps.cs.............hhcllAllDPlocp.AQ+hsslLh.lLpplh..sspl................+...lahN.sps.......cls.-..hP..l.K.p........FYRaVL-.sp..pF.ss.s...s....phs..t....PhApFh.slPpssLLTlshpsPpuWhVp.....shco..saDL.DNIhLpplpss............................VpA.YELEalLlEGHshD.......h....ss.s...p......P....P.RGLQhhLG...Tp..pp.Phhs..............DTIVMAN..............................	0	86	135	206
+6256	PF06428	Sec2p		GDP/GTP exchange factor Sec2p	Wood V, Studholme D	anon	Pfam-B_10665 (release 8.0)	Family	In Saccharomyces cerevisiae,  Sec2p is a GDP/GTP exchange factor for Sec4p, which is required for vesicular transport at the post-Golgi stage of yeast secretion [1].	22.30	22.30	22.60	22.90	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.33	0.72	-4.16	20	379	2009-01-15 18:05:59	2003-07-07 16:11:44	6	8	194	24	259	345	1	101.60	31	20.52	CHANGED	scltccccp+tpsEpppspLppElE-LTASLF-EANcMV....usA+tEppshchKNcpLccQL+Ep-sll-sLQtQLpsLKplhhs.....................hpspp.....spppptsst	........................p.pLp.ccppppchpph+pplppELE-LTAuLF.............EEApcMV....tpAp............h+p...sp.......hE+pLcEscscl-sLQtplttLKplh.p.....................................pt...........................................................	0	71	121	196
+6257	PF06429	Flg_bbr_C	DUF1078;	Flagellar basal body rod FlgEFG protein C-terminal	Moxon SJ	anon	Pfam-B_807 (release 10.0)	Domain	This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which Pfam:PF00460 is often present at the extreme N terminus.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.41	0.72	-4.06	463	11734	2009-01-15 18:05:59	2003-07-07 16:15:12	8	19	2105	7	2780	7802	1705	79.40	24	23.35	CHANGED	ssLp...phussL.a...ttss.............Gs..s...hs.s........ssss..............p...l..tpGhL..EsSNVsslcEhsshIsspRsYEhssKhlpsuDphhpp.sspl	.........................................................................................t...........h........................t..........................s.ss.....................tl....tpGhl....E....tSN.V.sl.spEhsshIpsQRuYpu.Ns+sls.o.s.cphhpphlp.......................	0	883	1749	2237
+6258	PF06430	L_lactis_RepB_C		Lactococcus lactis RepB C-terminus	Moxon SJ	anon	Pfam-B_717 (release 10.0)	Family	This family consists of the C-terminal region of RepB proteins from Lactococcus lactis (See Pfam:PF01051).	20.30	20.30	22.60	47.70	19.90	18.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.65	0.71	-4.06	13	139	2009-01-15 18:05:59	2003-07-07 16:23:41	7	3	51	0	9	140	2	119.00	64	33.07	CHANGED	KRhADDNSYKL-..DcsY.EDKspKEpsEcpLhhcAMcS.YTKLLhEpFLLSshDhTDsulMAGLQKNVYPLYDELK-LRGLNGVK-HLSYVuSKQEsYSKRNlAKYLKKAIEQYLPTVKRQDL	...............KRhADDNSYKL-..DpsY.csKtpKpcsEctLhh.pAMcS+YT+LLhEshLLSsh-hpDTslMuGLQcpVYPLYDELK-LRGLNGVKDHLSYVuSKpEsY..S..K+N.lAKYLKKAIEQYLPTVKRQDL.......	0	1	1	7
+6259	PF06431	Polyoma_lg_T_C		Polyomavirus large T antigen C-terminus	Moxon SJ	anon	Pfam-B_214 (release 10.0)	Family	\N	22.40	22.40	23.00	24.00	21.10	22.30	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.37	0.70	-5.82	3	1776	2012-10-05 12:31:09	2003-07-07 16:44:43	6	5	48	37	0	501	0	116.30	75	64.60	CHANGED	TKQVSWKLVTEYAlETKCEDVFLLLGMYLEFQYNsEpCKKCpKKDQPsHFKYHEKHYANAtIFADSKNQKSICQQAVDTVLAKKRVDSLHMTREEMLTERFNaLLDKMDLIFGAHGNAVLEQYMAGVAWLHCLLPKMDSVIYDFLKCIVaNIPKKRYWLFKGPIDSGKTTLAAALLDLCGGKALNVNLPLERLNFELGVAIDQFMVVFEDVKGTGAESRDLPSGHGINNLDsLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQARFVRQIDFRPKsYLRKSLpsSEFLLEKRILQSGMTLLLLLIWFRPVADFAsuIQSRIVEWKERLDpEISMYTFS+MKaNVuMG+sILDasREEDSEsEDSGHGSSTESQSQCsSQVS..-sSGsDoQSQsS......aHlCKGFQCFc+P	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................SSTESQSQC.SQVS..EASGADTQEHCT....................YHICKGFQCFKKP.....................................	0	0	0	0
+6260	PF06432	GPI2		Phosphatidylinositol N-acetylglucosaminyltransferase	Wood V, Studholme DJ	anon	Pfam-B_33496 (release 8.0)	Family	Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins. The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This  step involves products of three or four genes in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.	23.90	23.90	32.70	24.00	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.95	0.70	-5.06	37	324	2009-01-15 18:05:59	2003-07-07 17:06:08	6	9	277	0	237	310	4	271.90	29	80.42	CHANGED	W+KlLY..hcQsYPDNYo..D.poFLppLppNssltpa.........sahpllh-shslsQplssVslhhllFshlhppp..............................................lss.slhhhssshshhualh...hthht.t.s...................................................................................................................hhpsh+ohlllhhhlhhLSPlL+oLTcohSoDoIauloshlhlhalhhaDY..u.............htsh.stt...................htsslShNhulhuullLASRLsoshpVFshllhulplF...sLhPhhppp.l+ths.hhphhhshhhshhshhsh.............hhhshhhhlhahhhllhlshlsPh.......ahltlQpa.............KspIpGPWD	..............................................................................................WcKlLa...+Q.sa..PDNYs..D.tsFLcpLpcNhphp.Y.........................sah.tllhcssslsQplsslslahhha.hhhhptt........................................................................................l.sPh..lhhhsshh.shlGalh...hthh..t.t......................................................................................................................................................h.phhtsl+.osl...lh..hhhhhsLS..PlL...+oLTcohSoDoIaAho.hhhhlhp....lh.haDYu...........................................ht...st............................sslShNsAl.huossLASRLs..........oshcsFshhhhu.lplF...sLhPhhppp.l+...th....s....t.ht.hh..lshhh.sh.hshhsl....................h.hshhhhhh.hh..h..h..h..h..hh...hh..sPh.......hhlt.hQpa.............KppltGPWD...................................	0	79	127	193
+6261	PF06433	Me-amine-dh_H	Me-amine-deh_H;	Methylamine dehydrogenase heavy chain (MADH)	Finn RD	anon	Pfam-B_20644 (release 9.0)	Domain	Methylamine dehydrogenase (EC:1.4.99.3) a periplasmic quinoprotein found in several methyltrophic bacteria. Induced when grown on methylamine as a carbon source MADH catalyses the oxidative deamination of amines to there corresponding aldehydes.  MADH is a hetero- tetramer, comprised of two heavy chains (H) and two light chains (L).  The H-chain forms a beta-propeller like structure [1].	19.50	19.50	19.50	19.50	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.11	0.70	-5.81	5	83	2012-10-05 17:30:42	2003-07-08 09:40:06	6	2	76	105	32	104	19	332.60	33	86.65	CHANGED	DARRVYVhDPuHFAAlTQhYsIDGcouRlLGMTDGGFLPNPVVASDGSFFApASTVYSRIARGKRTDYVEVlDPpTapPIADIELP-uPRFLVGTYsWMsuLTPDNKsLLFYQFSPuPAVGVVDLEGKuFcRMlDVPDCYHIFPouNsoFFMHCRDGSLt+Vuaus-GsoK.hKsTEVFHsEDEYLINHPAYSs+SGRLVWPTYTGKIFQADLSupcAcFLsPIEAFTEAEKADsWRPGGWQQVAYHRApDRIYLLuDQR-cW+HKsASRFVFVlDAcTGKRLsKIELGHEIDSIuVSQDAKPhLYALSsGsKTLaIFDAsTGKELuSVDQLGRGPQlIhTuD	............................................tt....hhl.D....t.h....s.+.laV...hD..uDs....t+..l..LG.lsuuasss.hs.l.o.s..Dt+phYlAsTaasRss+GpRTDllphaDssTLphsuEI.lPst.+t...s.s.s.p.tsh.uhosDG+hhaVhNhTPusSVoVlDhsu+KV.l.p.pl-sPGCshl..Y..P..s..u..s..s.s.Fo.uLCtDGshhsVsLDssGK.s.s...pp.p..o..s..hF...s.sc.D.s.lFppssh...st..hsuphhF.soYsGpVhsschous.s...s.....p....h....t..t.shp......l........h.s-u.c.+............t...........t......sWRPGGaQ.hAlpt.....spp+hY.V.L.M.H.pG.s.p...toHKDsGTpVWVhDhpo+cRlsRhsL.t.p...t....ss...SlsV..op.D-.cPllaulss.ss........uslhVhDAt.o..G.c.h+shc.tlGps........hh..................................	0	7	17	24
+6262	PF06434	Aconitase_2_N		Aconitate hydratase 2 N-terminus	Moxon SJ	anon	Pfam-B_2605 (release 10.0)	Family	This family represents the N-terminal region of several bacterial Aconitate hydratase 2 proteins and is found in conjunction with Pfam:PF00330.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.27	0.71	-4.91	94	1563	2012-10-01 19:37:30	2003-07-08 12:39:19	8	6	1505	2	323	1212	908	208.10	67	25.23	CHANGED	loVFKV.sGETNTDDLSPAs-AaSRPDIPLHAhAMLcschss............slppItcLK.pKGhP....lAYVGDVVGTGSSRKSAsNSV.LWahGcDIPaVPNKRsGGlllGGp.IAPIFFNTsEDSGAL........................PIE.sDVsplphGD..VIsIh..PacGclpc.....tsG...................................................................................................................c...llupFpLpPsslhDEVRAGGRIPLIIGRuLTsKARpsLGL...ssSslFtpP......ppPss.su+Ga	...................................................................................lTVFKV.sGETNTDDLSPAP.DAWS..RPDIPLHALAMLKNsR-GItP-...sG.hGPl+pIEtLp.pKGaP....lAYV.GDVVGTGSSRK.SATNSV.LWFhG-DI.PaVPNKRuG..Gl..sLGGK.IAPIFFNTMEDAG..A..L........................PI..E...l..D..V.Ss.LsMGD..VI..D..lY..PYcGclpp.....tsG.........................................................................................................................E....llAsFcLKo-VLl.DEV.RAGGRIPLIIGRGLTsKAREuLGL...st..S..-lFRpscs.sA-.Ss+Ga...........................................................	1	74	178	263
+6263	PF06435	DUF1079		Repeat of unknown function (DUF1079)	Moxon SJ	anon	Pfam-B_1911 (release 10.0)	Repeat	This family consists of several repeats of 31 residues in length and seems to be exclusive to Moraxella catarrhalis UspA proteins. The UspA1 and UspA2 proteins of Moraxella catarrhalis are structurally related and are exposed on the bacterial cell surface where can function adhesins [1]. This family is commonly found with the Pfam:PF03895 family.	21.00	21.00	23.40	21.80	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.45	0.72	-3.94	4	220	2009-01-15 18:05:59	2003-07-08 12:51:55	6	19	12	4	9	218	0	29.60	52	16.20	CHANGED	lushhc.tcsascpQoEsIcuLsKASutNTs	lssh.ELtpQ.sp+po-.IcsLsKASutNTp....	0	0	9	9
+6264	PF06436	Pneumovirus_M2		Pneumovirus matrix protein 2 (M2)	Moxon SJ	anon	Pfam-B_2318 (release 10.0)	Family	This family consists of several Pneumovirus matrix glycoprotein M2 sequences. This family functions as a transcription processivity factor that is essential for virus replication [1].	25.00	25.00	134.20	134.00	22.00	17.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.90	0.71	-5.00	4	75	2009-01-15 18:05:59	2003-07-08 13:06:16	6	2	17	1	0	72	0	156.70	58	82.92	CHANGED	pWPsHsLLVRpNaMLNplL+shDRo.DsLS.ISGAuc.DRTp-asLGsssVlpsYIsu.sNITKpSAChuh.pllppLppsDlKphRDpcVssS.+ltlaNhVlSYI-.s.KNstphIp.LKRLPt-hLKKhhKhhI-lpsulphpNssssslpDttNs	pWPs+sLLlRpNaMLNplL+shD+S.DsLS.ISGAuc.DRTp-asLGsssVlpuYIss.sNITKpSAChuhppllppLppsDl+phRDNc.ssS.+VtlaNhVlSYlE.s.KsstphIp.LKRLPt-hLKKhhK.hlDlptuls.pNsppsslpDos..s...	1	0	0	0
+6265	PF06437	ISN1		IMP-specific 5'-nucleotidase	Studholme D, Wood V	anon	Pfam-B_43910 (release 8.0)	Family	The Saccharomyces cerevisiae ISN1 (YOR155c) gene encodes an IMP-specific 5'-nucleotidase, which catalyses degradation of IMP to inosine as part of the purine salvage pathway.	25.00	25.00	84.50	84.40	23.60	19.20	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.37	0.70	-5.76	18	157	2009-01-15 18:05:59	2003-07-08 13:32:53	6	4	137	0	127	156	1	373.80	47	89.08	CHANGED	MoSRYRVEY......tLKsHR+DpFI-W.............IKGLLAV.PFVLHut..t...................t....s.tthspcs+cRYuEIFpDVEpLIsc+Ithspp.sp.................spSRL+hLVPSIGsFFT.LPLp-AFhhpDc+RsISpRRhVuPSFNDlRhILNTAQlhuLsctt....................pLcLlTFDGDVTLY-DGtSLssssPVIsRLl.................cLLppslplGIVTAAGYsc...Ap+YhpRLpGLLcAlpsss.sLsssQKpNLlVMGGESNYLF+assss...stsLp.lscccWlLPcMpsWsppDIsplLDhAEpsLpchhppLsLP....ssIlRK-RAVGIlP..........pssh+lhR.EpLEEhVLslQppLEp...........................stsu..pcl.FCAFNGGsDVWVDIGDKuLGVpsLQ+aa...........t..ssIpsocTLHVGDQFhSsG.ANDFKARLuusTsWIAuPpETVplL	........................................................................p.....................pst..................................................lcuLLAs.PFVLau..t..........................p...hstcscppYs-IhcDlEthIp-+.Ithppt.st...................................t.S+LphLVPolG.sFFT.LPLpcAFhhpDppRhISpRRaVsPSFNDlRhILNoAQlhulsc.t.............................tLcLlTFDGDVTLY-DGtsLp..sssPlIs+ll.................cLLcpshplGIVTAAGYsp...As+Y.pRL+GLL-Alpss....sLsspQKpsLhlMGGESNYLFcasts...........htLp.......lsc...pcW.....h......hs...cMtsW.....s.c.....p..DIpplLDhAEpsLpphhppLsLP....ssIlRKcRAVGIlP...............................ssh+h.R.EpLEEhVLslQppLEh..............................................st.su..pclPFCAFNGGs...........DVaVDIGsKuhGVpshQpaa..............ssIpsscTLHVGDQFhssG.uNDFKAR..............susThWIAsPtETVplL.........................	0	35	73	108
+6266	PF06438	HasA		Heme-binding protein A (HasA)	Finn RD	anon	Pfam-B_27216 (release 9.0)	Domain	Free iron is limited in vertebrate hosts, thus an alternative to siderophores has been developed by pathogenic bacteria to access host iron bound in protein complexes.  HasA is a secreted hemophore that has the ability to obtain iron from hemoglobin. Once bound to HasA, the heme is shuttled to the receptor HasR, which releases the heme into the bacterium [1].	26.30	26.30	27.30	32.80	25.50	26.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.36	0.71	-4.92	7	96	2009-01-15 18:05:59	2003-07-08 15:17:58	7	2	67	21	10	66	4	204.00	39	99.08	CHANGED	MohSlsYsusauuaolusYLs-WuusFGDlsHtsups..sssNTGGFssGs..hsGoQYAlpSosss.tAFIAsGs....L+Yoh..sPu........HTLaGpLDoluhGcsL...uGGsu.us..asLss.-VoFssLsLsu.hupG+s......G.sVHpVlYGLMpGsouuLtsslsslLt..shGlSlNsTFDpluAAsss.s...husss.VshVGVQ-sspDhhLAA	..........................MosoIpY.sopausaoloSYLpcWusp....FGD..lsptsups...........ps....pGuFssus..........FsG..o..QYAl..s...Sop.......u..s.s..tu.h.......I....ApGD.......L+Yoh....Pp..............HThaG.p..l.DoLphGcsL...........s.su.su.sG....hpL-phclsFs.sLDlsu-h-su+shhp.........shpG.shHKulYGLM+GNssP.hL-hl........c....................ApGIslsTshKDluIASQhtsss..huDA..P.hlDTVGVh-.s.p-hLLAA.........................	0	1	3	5
+6267	PF06439	DUF1080		Domain of Unknown Function (DUF1080)	Yeats C, Eberhardt R	anon	ADDA_10682	Family	This family has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16. However, the structure surrounding the active site differs from that of the endo-1,3-1,4-beta glucanase.	26.30	26.30	26.30	26.40	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.51	0.71	-4.40	189	1312	2012-10-02 19:29:29	2003-07-08 16:01:14	6	119	323	12	583	1442	1367	194.00	21	46.62	CHANGED	sh...tsLF..s........Gc..sL.sG....Wp...sh..................................................................h.D.G.........................hlh.........................ssptsshlhoc...p.pas.sFpLcl-a.+.................ss..ss..............NSGlhh+sp........................................h..uh.EhQlhs......sttt..........................ptsGulY............................................................st...spsshssscWNphcI.hspusp............lp.h.hlNGhhlhchsphpst.t..............................ppGhIuLQ.sHu..........s............lp..FRNIpl+	.................................................................................................................................................hh.LF.s.Gp..sh.su....Wp...thttt...............................................................................................................lp-.G.........................hlh.........................tssssu..lh...o.....p.....c...pa.s.....sF.pLcl-a.+h...............st..su.............................NS.G....lhhpsp......................................h..uh.EhQlhs.....sttt.........................ttsGu.lY.................................................................st..spsshs...sG.cWNp....hcI..hs.p.usp..............lp..h.hl..N.G..h..hl..hchsphss.h................................................tpGhIuLQ..sHu............s.............tlt...FRNlplc.......................................	0	323	505	562
+6268	PF06440	DNA_pol3_theta		DNA polymerase III, theta subunit	Finn RD	anon	Pfam-B_27631 (release 9.0)	Domain	DNA polymerase III (EC 2.7.7.7) is comprised of three tightly associated subunits, alpha, epsilon and theta. This family contains the theta subunit.   The structure of the theta subunit shows that the N-terminal two thirds is comprised of three helices while the C-terminal third is disordered [1].   The function of the theta subunit is poorly understood, but the interaction of the theta subunit with the epsilon subunit is thought to enhance the 3' to 5'  exonucleolytic proofreading activity of epsilon [2].	32.30	32.30	32.40	36.10	30.60	32.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.41	0.72	-4.39	11	627	2009-09-13 11:27:20	2003-07-08 16:11:56	6	1	540	7	57	179	3	74.00	76	95.14	CHANGED	M..saNLApLScE-hDKlNVDLAASGVAaKERhNMPVlsE.VEREQPEHLRpYFRcRLtaYRptSppLs+hs.....-P+h	.......pNLAcL-QsEMDKVNVDLAAAGVA...FKERYNMPVIAE.sVEREQPEHLRuWFRERLIAHRLASVsLSRLPYEPK...........	0	2	12	37
+6269	PF06441	EHN		Epoxide hydrolase N terminus	Yeats C	anon	ADDA_11591	Family	This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds [1]. This family is often found in conjunction with Pfam:PF00561.	22.50	22.50	22.80	22.80	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.64	0.71	-4.15	143	1051	2012-10-03 11:45:05	2003-07-08 17:03:29	7	12	454	6	597	1123	575	110.20	35	27.04	CHANGED	pPF....plplscspLs-L+pRLptoRa...Pspts.sss............hp.hGsshshlccLscYW............................ts.sa..D................WRptEscLN...paPpFpTpI........-..................GlcIHFlHh+S......pps.sAl.PLllsHGWPGShhEFhclI	...................................pPFclplsppplsDL+pRLptoRh.....sst.....sss................ap.hG.hshshlcclscYW...................................ps..sY..D..................WRptE..ttLN...p.aPpFpTpI.......-..........................GlsIHFlHh+o.............................tps.sAl..P...L.l.lsHGW......PG..ShhEFhclI................................................................................	0	184	337	490
+6270	PF06442	DHFR_2	DHFR;	R67 dihydrofolate reductase	Finn RD	anon	Pfam-B_27527 (release 9.0)	Family	R67 dihydrofolate reductase is a plasmid encoded enzyme that provides resistance to the antibacterial  drug trimethoprim.  The R67 dihydrofolate reductase does not share significant similarity to the chromosomal encoded dihydrofolate reductase [1].	25.00	25.00	27.20	92.50	22.80	22.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.64	0.72	-4.35	3	33	2009-01-15 18:05:59	2003-07-08 17:07:36	6	1	13	8	0	18	0	78.00	81	96.15	CHANGED	MscSSNEVSsPVAGpFAFPSNATFGLGDRVRKKSGAAWQGQIVGWYCTsLTPEGYAVESESHPGSVQIYPVAALERVA	....................M-pusNEVSsPVAGpFAFPSNATFGhGDRVRKKSGAAWQGQIVGWYCTpLTPEGYAVESEuHPGSVQIYPVAALERls..	0	0	0	0
+6271	PF06443	SEF14_adhesin		SEF14-like adhesin 	Finn RD	anon	Pfam-B_36358 (release 9.0)	Family	Family of enterotoxigenic bacterial adhesins. 	21.90	21.90	22.10	22.70	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.03	0.71	-4.60	2	40	2009-01-15 18:05:59	2003-07-08 17:32:33	6	1	19	7	0	37	0	129.40	63	98.20	CHANGED	+St.ulhlhALhsCGuApAAshVGshAsVpAslshuAQNThsAsWoQDsuhoGsuVsAhQKlGTLsIphTGsHsuV.luGcssu.SGGlhTlPFhsstGQslFRGRhput.hps.ssshlst.u.GW+lsuoQ-shNlslpsF.stsslPAGpaTATFYlQQYQs	................................................ssTluAQNTTSANWSQDPGFTGPAVAAGQKVGTLSIT.ATGPHNSVSIAGK.GASVSGGVATVPFVDGQGQPVFR.GRIQGANIN..DQANTGIDGLA.GWRVASSQEThNlsl..............................	0	0	0	0
+6272	PF06444	NADH_dehy_S2_C		NADH dehydrogenase subunit 2 C-terminus	Moxon SJ	anon	Pfam-B_1662 (release 10.0)	Family	This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with Pfam:PF00361.	21.50	21.50	21.60	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.06	0.72	-3.66	136	25512	2009-09-10 16:36:32	2003-07-08 17:37:30	6	3	12030	0	41	25653	0	54.00	43	16.22	CHANGED	LaFYLRlsYshsLThsPsssssth.pW..Rhps.pp....shhls.hhhsholhhL.PlsPhlh.s	.....LFFYLRLuYssTlTlsPs.ossphp.pW....+hpp..sp.......shh.lu...hh...sshShhLL.Pl.o.Phlh.....................................	0	5	8	18
+6273	PF06445	GyrI-like	AraC_E_bind;	GyrI-like small molecule binding domain	Finn RD, Anantharaman V	anon	Pfam-B_36124 (release 9.0)	Domain	This family contains the small molecule binding domain of a number of different bacterial transcription activators [1].\	This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding [3].  The GyrI superfamily includes a family of secreted forms that is  found only in animals and the bacterial pathogen Leptospira [3]. 	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.75	0.71	-4.19	88	6066	2012-10-02 11:08:51	2003-07-08 18:33:54	10	24	2274	26	1074	4279	124	155.40	16	64.70	CHANGED	hphclhphsshplhulcppsshsp............lsphh.pplhthttppth.................tssshhulhhspst......spspphchthshthst........................ptstshphhplsuu.paAshpap.Gsh......ssltpshpplastalspssh....thtsssshEhYhss.........ttpphhs.-lhlPlp	......................................................................................................................................phplhph.s.php.lh...u....h.....p.t..p...h.s.p.t...............lsphh..p..ph..ht.hhhppth......................ssth.hul..h.h.s.ps.........t..t..sp....p...h..p.h..p..h..s.h.ss.sp........................................psspshp..h.pl.s..u.G...pYA.sh.p.hp...Gsh...........psht.c..shtt.lap..alsp.p.sh......................phtss.s...p....h....E..h..Y..hs..s.t..........pstphph..-lalPl..................................................................	0	387	718	907
+6274	PF06446	Hepcidin		Hepcidin	Finn RD	anon	Pfam-B_41732 (release 9.0)	Domain	Hepcidin is a antibacterial and antifungal protein expressed in the liver and is also a signaling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin [1].	21.90	21.90	26.30	25.80	19.90	19.70	hmmbuild  --amino -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.71	0.72	-3.56	20	197	2009-01-15 18:05:59	2003-07-09 10:43:59	7	1	91	5	26	181	0	55.70	42	64.69	CHANGED	chEEhtspDsssAttpptss-shth...hRpKRps.phshCtFCCsCC..+hpG..CGhCC+F	.....................pLEEsh.upDs.ssA.stpEhsh-Shhhs.t.Rp..KR.p......t..hC+.FCCsCC..phps..CGhCC+F.........	0	1	3	13
+6276	PF06448	DUF1081		Domain of Unknown Function (DUF1081)	Yeats C	anon	ADDA_12201	Family	This region is found in Apolipophorin proteins.	25.00	25.00	25.00	25.20	21.90	23.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.51	0.71	-4.21	22	170	2009-01-15 18:05:59	2003-07-09 11:20:46	6	14	99	0	78	163	0	116.10	27	3.77	CHANGED	sschppp...sCh.shlc.hhGlphChsh..shssl.ps......puh..........PLusPshhcl.lcts-.phctYphpushctpp....ss.....cpl+htlcs.Gupss+-upsslpas+cpcsh............................louclptsshsuc	.............+.shssCp..shhs....GLphCssh..sas..sssss.................sus.........shaPLoGssphpl.Lc.ss.phcpYshphsachpc....ts........................cshchshps..G.........sp..pcsshshp..hspppts.............................hp.pl....h...t....................................................................	0	21	28	55
+6277	PF06449	DUF1082		Mitochondrial domain of unknown function (DUF1082)	Moxon SJ	anon	Pfam-B_2173 (release 10.0)	Family	This family consists of the C-terminal region of several plant mitochondria specific proteins. The function of this family is unknown. This family is found in conjunction with Pfam:PF02326.	25.00	25.00	44.80	43.80	23.00	20.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.51	0.72	-4.08	5	109	2009-01-15 18:05:59	2003-07-09 11:38:49	6	3	77	0	7	82	0	49.70	77	30.50	CHANGED	DLLGK+RKIThISCFGEISGSRGMERNILYLISKSSYST.ss..oGWtIT...C+N	DLLGKR.R.KITLISCFGEISGSRGMERNIhYLISKSSYST..........sGhtITC+N........	0	1	4	6
+6278	PF06450	NhaB		Bacterial Na+/H+ antiporter B (NhaB)	Moxon SJ	anon	Pfam-B_5993 (release 10.0)	Family	This family consists of several bacterial Na+/H+ antiporter B (NhaB) proteins. The exact function of this family is unknown [1,2].	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	515	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-12.95	0.70	-5.88	4	838	2012-10-02 15:12:49	2003-07-09 11:48:14	7	2	810	0	104	725	503	497.90	75	99.01	CHANGED	M.hohupAFh+NFLGpSP-WYKlAIlsFLIINPIlFFhISPFVAGWLLVAEFIFTLAMALKCYPLQPGGLLAIEAlhIGMTSAppV+cElhANlEVLLLLlFMVAGIYFMKQLLLFlFTKlLlpIRSKhLLSLuFChAAAFLSAFLDALTVlAVlISVAVGFYuIYHKVASGpsh.tDpDhosDs+IpE....hp+s.LEpFRuFLRSLhMHAGVGTALGGVhTMVGEPQNLIIAcQAsWpFGEFhlRMSPVTlPVFICGLLTChLVEKh+lFGYGtpLPDpV+cILsDaDcppccpRTpQDKhKLhVQAlIuVWLIsuLALHLAuVGLIGLSVIILATSFTGVTDEHulGKAFpEuLPFTALLsVFFSVVAVIIDQpLFuPlIpaVLssE-p.TQLuLFYlhNGLLS.lSDNVFVGTVYINEsKAALhsGhIThcQF-LLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVaMALPYTlVLoIVGLhuIpFh.LtssTtaFhshGhIhs	......................................MclShGpAhh+NFLGpSPDWYKLAlllFLIlNPllF.hl.uPFlAGWLLVAEFIFTLAMALKCYPL.PGGLLAIEAVhIGMTSs....cH.................V+EElAANLEVLLLLMFMVAGIYFMKQLLLFIFT+LLLuIRSKhlLSLuFClAAAFLSAFLDALTVVAVVISVAVGFYGIYH+VASu+s....-.-..sDhpDDS.+I..-.c....c.h+ssLEQFRuFLRS...LMMHAGVGTALGGVMTMVGEPQNLIIAK.sAG......Wc..FG-F..FL.RMu.P.VT.V..P..V..L.I..C..G..L.L.TChLVEK..h..R..hF.G..YGp.pL..PE..+.V.R.cV..Lp.pFDcpu.R+.p.R.T..+..Q.D...K..l.+L.......I.V..Q..A..l..I..GV...W.L.V...s....A.L.A.LH....L......A..E.VGL....I.G.LS..V....I.IL.ATu...hT..G.V.TD.EHA.I.........GKA.F.......p.....Eu.L.PF.T..A.L..L..TV..FF.S.VVAVIIDQpL.....Fu.PII..Q.FVL.Q.....A...S..-.H....uQ..L....o...L..FY.l......F..NG..L...LSSISDNV.FVGT.l...Y..I...NEAKAAhEs.........G....sI.ohc......Q.a.EL......LAVAINTGTNLPSVATPNGQAAFLF..LLTSAL...APLIRLSYGRMVW..M..ALPYTlVLTLVGLLsVEFh.LsPsTEWhhphGWIu.o.....................................................................................................................................................	0	21	42	77
+6279	PF06451	Moricin		Moricin	Finn RD	anon	Pfam-B_56760 (release 9.0)	Domain	Moricin is a antibacterial peptide that is highly basic. The structure of moricin reveals that it is comprised of a long alpha-helix.  The N-terminus of the helix is amphipathic, and the C-terminus of the helix is predominately hydrophobic.  The amphipathic N-terminal segment of the alpha- helix is mainly responsible for the increase in permeability  of the bacterial membrane which kills the bacteria [1].	25.00	25.00	25.50	25.10	19.30	19.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.84	0.72	-4.46	2	23	2009-09-10 20:06:58	2003-07-09 11:52:21	6	1	10	3	6	26	0	39.20	59	54.24	CHANGED	uKIPItAIKpsGKAlGKGLRAlNIASTApDVasFhKPKKR+	..uKIPltAIKKuGKAIGKGLRAINIAuTAHDVaoahKPKK++....	0	3	6	6
+6280	PF06452	DUF1083		Domain of unknown function (DUF1083)	Moxon SJ	anon	Pfam-B_2203 (release 10.0)	Domain	This family consists of several domains of unknown function exclusively found in bacterial xylanase proteins (usually at the C-terminus) although it is tandemly repeated in a number of family members such as Swiss:P38535. This family is always found in conjunction with Pfam:PF00331 and usually with either Pfam:PF02018 or Pfam:PF00395. The function of this family is unknown.	20.80	20.80	20.90	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.34	0.71	-4.41	35	615	2009-01-15 18:05:59	2003-07-09 11:58:29	6	91	276	3	254	667	374	179.60	17	25.09	CHANGED	I.DGps.DssWssAp...lshsphh....tus.....sssoush+sLWD.-csLYlLscVsDsl.lscsssss....a-pDulEIFlDpsNsK...sstYpssDhQY+lsasNpso....hssss...........hssshpousphss.sGY.....llEstIsh............psl.....sssssph...lGFDltlND.ssssGsRpuhhsWsDsosss......apssusFGslpLttp	................................................lDG.h..-t.W.ppst....hs.....h.h................ts.t..........ssh..psp..s+.hha..D..c....psLYlh..s.......p....l...p....Ds.....p.....h.....p.....p......tttss.............ha...p...s.Ds.lE.l.a.l...D....ssssp.......psta.....p.......h......p.....s......s....t..h.........t....h.....t.h..s...s..h..t.s........hphtt..................................................hs.sth..p...s..t.sp.........h.........s.........s...sua..........hhEhtIPh.....................psl........t..t.ts.ph.....huhs...h..........h.p...............................................................t........................................................................................................................................	0	130	216	243
+6281	PF06453	LT-IIB		Type II heat-labile enterotoxin , B subunit (LT-IIB)	Finn RD	anon	Pfam-B_61882 (release 9.0)	Domain	Family of B subunits from the type II heat-labile enterotoxin. The B subunits form a pentameric ring, which interacts with one A subunit.  Thus, the structural arrangement of type I and type II heat-labile enterotoxins are very similar [1]. 	25.00	25.00	139.10	139.00	20.60	19.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.54	0.71	-4.44	2	7	2009-01-15 18:05:59	2003-07-09 12:17:58	6	1	2	15	0	7	0	121.70	64	99.77	CHANGED	MS.KKIItAFVlMsullSsQsaAGsSpaF+s.CNpTTAslVtGVpLpKYIuDlNsNTcGhYVVSsTGGVWhIstu+DYPDNhhouEhRKhAMAAlLSsh+VNhCApsuSSPNhIWAhEL-tE	MsFKK.IuhhhlhhsIsSl.sYAGVScpFKDpCspTTAclVpuVQLsKhhSDlNpso+GIYlsSSTGtsWaIPGGp.YPDNaLSsEMRKIAMAAVLSssRVNlCASpA.oPNHlWAIELttE..	0	0	0	0
+6282	PF06454	DUF1084		Protein of unknown function (DUF1084)	Moxon SJ	anon	Pfam-B_12888 (release 10.0)	Family	This family consists of several hypothetical plant specific proteins of unknown function.	25.00	25.00	25.20	25.20	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.83	0.70	-5.37	10	304	2009-01-15 18:05:59	2003-07-09 12:39:16	6	6	72	0	206	287	1	218.40	26	53.16	CHANGED	husosssult....ssWWDplNE.SshWQDsIFauLuulYGLVSsVALlQLIRIph.RVPEYG..WTTQKVFHLhNFlVNGVRAl.lFuF+.....+pV.plpPcllp..tlLLDlPGLsFFoTYsLLVLFWAEIYaQARu...LsTD+LRsuFaolNuVlYhIQIsIWlhlWhpPss....sl.hluKhFhAslShhAALGFLLYGGRLFlMLRRFPIESKGR+KKL+EVGhVTsICFoCFLIRClh....hslsAFDscAcLDVLsHPlLNhlYYllVEILPSuLVLFILRKLPPKRspsQYHPIp	....................................................................................hhh.........................................h.lshhhhhluhhuhhQ.l.h.......ph.......h....+.........p.hs......hs...hp+lhhhh.......h...l..s......s......h................h.Rsh...hFhhh.....................ph.....ht.........t..hhp......hlLhshPsh...ha.aosasll.llaW...sclha.....p.u.ps........h..t...p..t....l...p.........hhhl.Nsh..lY...h.h....tl..hl...al...h......h..h.hp...t.....................hh.hh..th......h.h....u....sl.....h...h.h.uh....u.FhhYGhpLahh..l.........p............p...........h.........p......t..p.t.....p......p..p...c..h............c..lshlshl....s.hsFhh+shh.......hh......h......s.....h.................t....h...t..........h.....t.....l...h...........hhhahhsEhlPs.h.lLahh.............................................................	0	75	157	185
+6283	PF06455	NADH5_C		NADH dehydrogenase subunit 5 C-terminus	Moxon SJ	anon	Pfam-B_3060 (release 10.0)	Family	This family represents the C-terminal region of several NADH dehydrogenase subunit 5 proteins and is found in conjunction with Pfam:PF00361 and Pfam:PF00662.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.01	0.71	-4.90	78	9824	2009-01-15 18:05:59	2003-07-09 12:48:11	6	10	5550	0	166	9403	1036	165.20	32	35.29	CHANGED	YShRllaashhGpsphsshsslNEss.hllsslhtLuhGSIhuGhhlohhlhP..psshhshPhhlKhhALhVollGllhuhplsshohp.hp.s......shppF.shhhFhP.lspphhsphsLhhGpplspp.hDpuWhEhhGspGlhph.hshophhpshQpu..lKhYLhhFllslllhhhhh	...........................................................................YShRlh...a..ashhG.p.....p...a.....o....l..p...s....l..N...-.p....s....h.h..lp..sh.htLhhhSIh.............uG...........................h...........l...............s..................................I...............h.................P......p................s......................h............h................s...................h.................P............h............................L...K......h......h.AL....h..V....o....l....l.G.h..h.l......u.............h.......-...........l...s....p...h....o.......................p.....h....h.....................p.....p.................t..................s...............h.hF..shh....hahPsl.ph.hhshh.s.Lhh.u..plhpp..hD.sW...E.h..h.Gsp.u.h..ph..h..p..o.hh.hp...Q.p.s..hK...h..Y...hh.hhlhhhhhhh...........................................	0	50	91	119
+6284	PF06456	Arfaptin		Arfaptin-like domain	Finn RD	anon	Pfam-B_5314 (release 7.5)	Domain	Arfaptin interacts with ARF1, a small GTPase involved  in vesicle budding at the Golgi complex and immature secretory granules.  The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix  coiled-coils [1]. The N-terminal region of ICA69 is similar to arfaptin [2]. 	32.00	32.00	33.60	33.40	31.20	31.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.31	0.70	-5.01	11	535	2012-10-03 12:17:00	2003-07-09 12:49:09	8	12	97	10	285	472	0	209.60	33	55.43	CHANGED	lhpKlc.......ppa+po+QlhpcphG+tpcp+h.ssDsEL-splElL+sspcpYtsllchscshpptlhplspsp+tLGchFppluh..Kspphscthstsu-sh+hluKpt.sLhsslphhlsclsTahs+sIsDThhTlcphEssRhEYcuhphclK-hspELsPpsstphshaRpsQsph.........ppsKc+a-KL+sDVh.Kl-LL-ps+spslsppLttapsslutaappsuctL	..........................................p+hp.......ppahpT+Qhh.cphG+tpc......ssD..s-.L-sp..lE.........lh+sspcphpsllch..sct...hppp.hhplsppp.ptLGchhpshu....co.thtcthshsucs.phhs+p.t...sLh.ss.lshhhp.slsThhp+sIpDThhTlpphEp..s.RhEYc.uhhh.hc-.h...s...hsPps........t..tp..h.+h..ctsQtph.........................pt.t+.p.pa-Kh+tDVh.KlchLtts+sphhpppLhha...p.ssl.taattstp.h......................................	0	83	103	191
+6285	PF06457	Ectatomin		Ectatomin	Finn RD	anon	Pfam-B_63420 (release 9.0)	Domain	Ectatomin is a toxic component from the Ectatomma tuberculatum  ant venom.  It is comprised of two subunits, A and B, which  are homologous.  The structure of ectatomin  reveals that each subunit is comprised of two helices and a connecting hinge region, the forms a hairpin structure that is stabilised by disulphide bridges.  The two hinges are connected by a disulphide bond [1].	25.00	25.00	82.10	82.00	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.84	0.72	-4.25	2	2	2009-09-11 06:57:38	2003-07-09 13:43:24	6	1	1	2	0	2	0	34.00	47	95.77	CHANGED	hsphlh.TlCPTlcshAKKCpGsIAThIK+cCsK	hsphlh.TlCPTlcshAKKCpGsIAThIK+cCsK	0	0	0	0
+6286	PF06458	MucBP	DUF1085; 	MucBP domain	Galperin M, Moxon SJ, Bateman A	anon	Pfam-B_4243 (release 10.0) & Galperin M	Domain	The MucBP (MUCin-Binding Protein) domain is found in a wide variety of bacterial proteins. The domain is found in bacterial peptidoglycan bound proteins and is often found in conjunction with Pfam:PF00746 and Pfam:PF00560.	22.60	22.60	22.60	22.60	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.82	0.72	-3.39	115	1918	2012-10-02 15:23:12	2003-07-09 13:51:03	7	136	317	12	279	1856	8	103.00	26	27.90	CHANGED	hspssshTlpYlct.s......Gspls.ss...........................-hlT..G..hh...........................................scsa...ssss...sI..sGY...............................sht..sh..sss.ss.hshssss.sV	..................................................h.sKslTRTIpYhts.s..............Gpp.....s......t....t.....s.....h.....s.Q.s..l........sao...................Ro.............ssh.DpVT........Gplsh..............................ssWss...............tsssa....stl...ssP......sl......sGY................ssshsssstpsV..................................ss.ssp...sh....phsVs..Yptpst......................................................	0	49	98	163
+6287	PF06459	RR_TM4-6		Ryanodine Receptor TM 4-6	Yeats C	anon	ADDA_12111	Family	This region covers TM regions 4-6 of the ryanodine receptor 1 family.	25.10	25.10	26.30	26.30	25.00	24.70	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.99	0.70	-4.50	21	301	2009-01-15 18:05:59	2003-07-09 14:40:33	7	42	92	0	144	243	0	247.80	36	6.13	CHANGED	sMPDPTQstl+G.....-h.ptccsth.ptssstp.h.......ustcEschhs-.....hhGlthcKEGu..h...hssssGLuDhuph.s.tssospsssht+p.........................ttttpsps-sphsDhcsGEK.....pp.sc.ppp...ppsh.t.httppp+spctcc..thhhphatt.............lphhppKhlNYLARNFYNLRaLALFlAFAINFILLFYKVosp.ss---c.t.........................................tsthss..----..-csh.hahLp......EooGYM.tPsLphLAllHTlISFhClIGYYCLKVPLVI	...............................................................................................................................hP-PTt.tl+s...........ph.pt...t...t..h..pt....t.t.h.......t.tt-t-hhs-.........hhGht.......c+EGu..p......htspsGLuDh...p..s...t.s..s..ttsshtct.........................................................t.ttptc..ps..cscc....A..-hEsGEK......ttt..ctp..t.............sp..p.p....tptpsp+h....tcs..ps.h.sphatt..................lp.happK..hLs..YLARNFYNLRaLALFlAFAINFILLFYK.Vosp.sstc.tpt.t............................................s.sshsp...-c--...--shlaahLp......ESo.GYM.pPsLRhLAllHTlISFhClIGYYCLK.....VPLVI..................	0	20	31	85
+6288	PF06460	NSP13		Coronavirus NSP13	Yeats C	anon	ADDA_12678	Family	This family covers the NSP13 region of the coronavirus polyprotein. This protein has the predicted function of an mRNA cap-1 methyltransferase function ([1]).	20.10	20.10	20.10	20.30	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.66	0.70	-5.55	8	426	2012-10-10 17:06:42	2003-07-09 15:53:49	7	37	250	4	0	450	56	280.30	61	5.15	CHANGED	uu-WpsGYuMPsLYKhQchsLE+CNLaNYGtslsLPsGIMhNVAKYTQLCQYLNoTTLsVP+NMRVLHLGAGSDKGVAPGoAVLRpWL..........PpssILVDNDlsDYVSDAchSlhGDCsTlhh-sKaDLlISDMY....DsppKslst-NsSK-GFFoYl.suhI+-KLALGGSlAIKlTEaSW.NtcLYcLhp+FuaWThFCTuVNsSSSEuFLIGlNYLGc.ss+spIDGssMHANYlFWRNoshhphSt.SlhDhSKFshKhpuTsVVsLKpppls-hVhuLlcpGKLLlRsssphlhhusphVsss	....................................................ussWpPGYuMPsLYKhQphsLEhCsL.NYGtslsLPsGIMMNVAKYTQLCQYL.NTs.TLsVPaNMRVlHhGAGSDKGVAPGo..sVL+QWL............PsGolL.VDNDlsDaVSDAcsolhGDCsolhhpsKaDLlISD.MY....DspTK.plsttNsS.K-GFFTYl.sshI+pKLALGGSlAlKIT...EaSW.NtcL.Y.cLht.c.FuaWThFC.T.sV.N.AS...SS.EuFLIGlNYLGc..sK.pIDGpsMHANYIFWRNoshhphSuYSlFDhuKFs.LKL+uTsVlsLK-sQlNDhVhuLLc+G+LLlR-ss+hlssuD.LVN...........................................	1	0	0	0
+6289	PF06461	DUF1086		Domain of Unknown Function (DUF1086)	Yeats C	anon	ADDA_2403	Domain	This family consists of several eukaryotic domains of unknown function which are present in chromodomain helicase DNA binding proteins. This domain is often found in conjunction with Pfam:PF00176, Pfam:PF00271, Pfam:PF06465, Pfam:PF00385 and Pfam:PF00628.	25.00	25.00	30.70	29.20	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.89	0.71	-4.41	4	315	2009-01-15 18:05:59	2003-07-09 16:22:00	6	49	98	0	143	249	0	148.60	65	9.03	CHANGED	.ssup........pctspsspRP.R++tR-sp-c..sPLhtt.GtplcVLGFNtpQRchFlpslMRaGh...s.hp.p..V.cL+tKo.c.FKtYu.LFh+HlsEsssDNSsoF........uDGVP+EGLsppcVLsRIulM.Ll+cKVQ.hEcasGc.shPphh.	.........tsssE-s--p.......cs..t..sRR..sR+.p..L.R..s-+DKP...LPPLLARVGG.NIE.VLGFNsRQRKAFLNAlMRaGMP..............PQDAF.soQWL......VRDLRGKSEKEF.K..AYVSLFMRHLCEPG...A...DGuETF........ADGVPRE....GLSRQ.HVLTRIGVMSLlRKKVQEFEHlNGcaShP-L..h................	0	29	51	89
+6290	PF06462	Hyd_WA		Propeller	Yeats C	anon	ADDA_3361	Family	Probable beta-propeller.	20.70	20.70	20.70	20.90	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.05	0.72	-7.38	0.72	-4.30	73	1060	2009-01-15 18:05:59	2003-07-10 09:19:19	7	43	91	0	606	1024	6	32.70	33	16.01	CHANGED	stVWAls.pc.........GplhhRp.......GlopssPpGss..Wppls	........tVWAls.pp........................GplhhRp.......Glos.p.s.PpGss..Wppl........	0	133	188	369
+6291	PF06463	Mob_synth_C		Molybdenum Cofactor Synthesis C	Yeats C	anon	ADDA_4938	Domain	This region contains two iron-sulphur (3Fe-4S) binding sites. Mutations in this region of  Swiss:O14940 cause MOCOD (Molybdenum Co-Factor Deficiency) type A.	24.00	24.00	24.60	24.10	23.60	23.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.86	0.71	-4.45	66	3853	2009-01-15 18:05:59	2003-07-10 14:48:39	8	19	3317	8	1051	2921	1184	127.60	32	37.19	CHANGED	hplRFIEhMshGpspph......cphlshpplhstlpppath..hsst.tps...susAchapl...........ssst.up.....................lGhIsshops.FCssCNRlRLTu-GpL+sCLatpps.h-LRshL+sss.stt....LtphlppultpKtttath	..............................................plRFIEhMshG.p......s.s.....th...tt...........pphlotpplh..sp.l...p.p...c.h...l......tt.hp...tpp.............suPAphaph................s.sht...uc.............................lGlIsshocs.FCuoCNRlRlou-GpLh.hC......LFupp....s..hsLRshL....Rss.......s....pppt.............Ltpt.lpps.l.ppK.ppa..h..............................................	0	333	659	885
+6292	PF06464	DMAP_binding		DMAP1-binding Domain	Yeats C	anon	ADDA_4672	Domain	This domain binds DMAP1, a transcriptional co-repressor.	27.00	27.00	27.00	27.70	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.26	0.72	-3.47	20	421	2009-01-15 18:05:59	2003-07-10 16:02:57	6	20	154	0	223	376	0	97.80	28	7.19	CHANGED	ssssLPt-VRc+Lp-L-h-hspGslTpKGYpKK+s+LLppFL.................................tscsppphtsppsth+cc.chpp-lapps.VpAhLsKptppchuhshsscccssh	...................s.......clpt.pLtpL-.-.hp.pGDITpKGYpK++spLLt...tal......................................................................t........t...........tst.......p.ph.phtst.psp..php..........pcha.htt.lpuhls+...p.c.........p...................................................................................................	0	35	62	128
+6293	PF06465	DUF1087		Domain of Unknown Function (DUF1087)	Yeats C, Sammut SJ	anon	ADDA_2403	Domain	Members of this family are found in various chromatin remodelling factors and transposases. Their exact function is, as yet, unknown.	20.80	20.80	20.80	21.10	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.18	0.72	-4.05	14	335	2009-01-15 18:05:59	2003-07-10 16:07:05	8	54	109	0	159	267	0	64.50	60	3.87	CHANGED	pthttcp-ps.s-shtt..ps.cssaW.cLL+++YEpppt-ctppLGKtKRsRKQVsYs-t.sslps	.....................c..Etcc.EElEREIIKQE..E.s..V.D...PDYWEKLL...........RHHYE..QQQEDLARsLG.KGKRlRKQV..N...YNDu.uQED............	0	34	65	106
+6294	PF06466	PCAF_N		PCAF (P300/CBP-associated factor) N-terminal domain	Yeats C	anon	ADDA_4771	Domain	This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold -  though predominantly helical.	19.70	19.70	43.40	23.00	19.20	18.00	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.75	0.70	-5.05	3	179	2009-09-11 14:37:09	2003-07-14 11:28:16	6	8	84	0	111	162	0	215.60	57	31.42	CHANGED	RIuQRKAQVRuLPRAKKLEKLGVYSACKAEEoCKCNGWKNPpPsss.PRtDLQQs.sssLoEpCR..SCcHuLAuHVSHLENVSE-EMNRLLGhVlDVENLFMSVHKEEDsDTKQVYFYLFKLLRKCILQRs+PVVEGSLG.cPPFEKPsIEQGVLNFVQYKFSHLuo+ERQTMhELAKMFLNpLNYW+LEoPSQRRtRSssEDlSsYKlNYTRWLCYCHVPQFCDSLPRYETT+VFGRTLLRSVFTlsRRQLLEKs	...........................t.s..pKl.KLuhaSuCp..upp.CKCsGWK....sPpssst.....s+..............hDlp..p....h.....sshs-.CR..oCpHsL.s.sHluHL.-slSE-EhNRLLGhVlDVEpLFhsVH...KEE..D.s.D.TKQVYFYLF.K.LLRKsILp.hs+PVlEGsLt....pPPFE+PsIp..p..uV.NFV.YKFSHL.s.s+EpQTh.hELuKMFL.plNaW+LEsPoph...RtR..s...s.-.Dh....usYKlNYTRWLCYCpVPphCDSLP+YETopVFGRoLL+SlFsshRRQLL-p...........................	3	27	34	74
+6295	PF06467	zf-FCS	zf_MYM; zf-MYM; 	MYM-type Zinc finger with FCS sequence motif	Yeats C	anon	ADDA_4806, Iyer L	Domain	MYM-type zinc fingers were identified in MYM family proteins [1]. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1 [2]. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1 [3]; in atypical myeloproliferative disorders it is rearranged [4]. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons [5].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.75	0.72	-4.32	56	1780	2012-10-03 05:12:49	2003-07-14 11:43:49	9	35	200	2	719	1712	47	41.30	25	16.45	CHANGED	ttssspspCphCpp.h..stpt......hphp......uphppFCSpsChspa	..........t...hhthpCshCpp.h.tptpp.........hphp......GphcpFCSpsChspa......	0	60	95	259
+6296	PF06468	Spond_N		Spondin_N	Yeats C	anon	ADDA_5023	Family	This conserved region is found at the in the N-terminal half of several Spondin proteins. Spondins are involved in patterning axonal growth trajectory through either inhibiting or promoting adhesion of embryonic nerve cells ([1]). 	20.90	20.90	20.90	21.60	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.17	0.71	-4.62	17	420	2009-01-15 18:05:59	2003-07-14 12:07:36	8	35	159	3	258	396	23	167.40	30	35.50	CHANGED	tA+YclsFpGhWSppoHPKcaPhh..ss+aSsllGuoHossYphWp.GphASsGl+phAEtGsshtL-pElct..tup+l.....................................polhpshu...hsuh.sssGpssuphcVDs.pHphlShlshlsPSPDWhVGVsul-LCpss.sWh-phsl-LaPaDAGTDSGhTapSsNtsTlPt-hlppITop.PscPtuPFYsPcupphsP	.....................................Yph.h.t.Ws.t.aspp.aP.................spaSsll....G.suHsss.a.p.haphG.........ph..A.SsGl+phAEtGsst.tLt...p.-hpt..........t.sp..t..h.........................................................olhpshu............t.h....s.s.s.u..p....s...ps..ph...p.l-p...p+.ph.lShh...shlsPSPDWhV...G...l...s...u...hcLCp....ts..sW..hpp.hs...hsL...hP..aDAGTDuG.o....a...uss..p.P.t.h....hp..s.....p..ssah.......................................................	0	79	111	198
+6297	PF06469	DUF1088		Domain of Unknown Function (DUF1088)	Yeats C	anon	ADDA_5036	Family	This family is found in the neurobeachins. The function of this region is not known.	20.80	20.80	20.80	20.80	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.18	0.71	-4.84	6	183	2009-01-15 18:05:59	2003-07-14 13:31:26	6	14	83	0	96	151	0	165.00	61	7.11	CHANGED	EGRLLuHAMKDHlVRVANEAEFILNRQRAEDVHKHA-FESpCAQYsADRREEE+MCDHLIsAAKaRDHVTAsQLlQKIlNILTsKHGAWGs.u.sSpsp-FWRLDYWEDDLRRRRRFVRNPaGSoHsEATLKAuhEa...........sssE-plhph+cshpSQshsspN..scsEL.....lL-uD	..............EGRLLsHAMKDHlVRVANEAEFILNRQRAEDVHKHAEFE..............Sp..CAQYuAD+REEEK..MCDHLIoA....AK+RDHVTAsQ.Lh.QK........IlNILTNKHGAW............G...s...........s......u......t.............S..........p..........h.....+-FWRLDYWEDDLRRRRRFVRNPhGSTHsEAoLKu.AlEa................................uss.E.-tl.hKuKpsh+SQs..lssQN..sEsElhL-u............................................	0	26	35	61
+6298	PF06470	SMC_hinge		SMC proteins Flexible Hinge Domain	Yeats C	anon	ADDA_5420	Domain	This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction ([1]).  	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.20	0.71	-4.14	102	3948	2009-01-15 18:05:59	2003-07-14 13:45:41	8	39	2700	16	1605	3541	451	116.80	25	9.96	CHANGED	hpu.lhGhls-llpl..sppac..t.AlpssLGsplp.sllVcstpsApphlphlc.pt........p.....hG+s.shlsLsplpspthp......................................sst.llphlph.s...phptsl..phllussllscsl-pA..tpls	.................................................h..GlhGtlu-Llpl...cp...cap....t..AlEsuLG.s..........s.hp.pll.V..-..s..p..c..s..Appslph.L+.pp................................p......hGRs..TFl...PL.s..p..l.psps.h.s..tt.tt.........................................................................shssh.hh.-.ll.p....h..-.........tphps.sh....p....lLG.ssllscslcpAppl..............................................................................	0	578	968	1353
+6299	PF06471	NSP11		NSP11	Yeats C	anon	ADDA_6050	Family	This region of coronavirus polyproteins encodes the NSP11 protein.	25.00	25.00	37.30	36.70	18.30	17.80	hmmbuild  -o /dev/null HMM SEED	594	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.02	0.70	-6.32	11	410	2009-01-15 18:05:59	2003-07-14 13:59:22	7	36	245	13	0	420	0	562.60	60	10.13	CHANGED	scLQu..p..ssGLFKDCuKs.pslpPAaAsTalSlsDcaKss-sLAVplss..sssloYp+lIShMGF+hDlslsGYpsLFlTRDtAlRpVRuWlGFDVEGAHAstsNlGTNlPLQlGFSTGVsFVVpPpGhlsTcpGsshcsVsAKAPPGEQF+HLlPLM+KGpPWsVVR+RIVQMluDhLssLSDhllFVhWAtGhELTThRYFVKlGhEppCp.Cu+RATCYsSssss...YuCa...+HulGsDYVYNPahlDIQQWGYsGsLosNHDthCsVH+sAHVASuDAIMTRCLAIHDCFsKsV-WslpYPhIuNEppINpuCRhVQphll+AAlpsh+ssslaDIGNPKGI+CVsp.-scWpaYDppPlsp...sVKpLcYsYtsHtp.FtDGLChFWNCNVDpYPpNulVCRFDTRshSpLNL.GCNGGSLYVNKHAFHTPAaD+pAFt+LKPhPFFYYsDosCEshp.......cpV..sYVPL+ossCITRCNlGGAVCpKHAs.Y+pYlEuYNhhssAGFolWVs+sFDsYNLWpTFop...LQSLENlAYNVVKpGpFsGlsGELPVAIlNDKVal+ssssDshlFsNpToLPTNVAFELaAKRplphpPsls	........t.LQs.....psTGLFKDCSKphs.GlHPuaAsTahulsspaKss-s.LAVslss.hspshTYp+LIShMGFKhsh.....slsGYpshFITR-EAIRpVRuWlGFDVEGsHAst-slGTNlPLQlGFSTGlsFVVpspGhVsTcpGspFphVsAKuPPGEQFpHLIPLMp+GpPWpVVRhRIVQMluDpLpsLSDpVVFVhWAtG.hELTohRYFVKIG.EpsCs.Cs+RATCasSposs...YuC..W...+H....ul...G...hDYlYNPhhlDlQQWGYoGsLp.NHD.aCsVHtsAHVASuDAIMTRCLAla-CFsKcVsWslpYPhIuNE.plNsuCRhlQ+hhl+AAlhs.+hsllaDIGNPKuI+CVtp.-lpa+FYDtpPlss...sV+pL.YsYtsH+DpFtDGLChFWNCNVDpYPsNulVCRFDTRsLSsLNLPGCNGGSLYVNKHAFHTPsFD+sAFppLKshPFFYYsDSPCEhhs......sspl..DYVPL+SssCITRCNlGGAVC+KHAp.YRpYl-uYNhhsoAGFolWlh+sFDsYNLWpTFop...LQSLENVAYNlVppGHFsGhsGEhPsuIls-+Vhs+ssshDstIFpNpToLPTNVAFELaAKRsI+.hPpl......	0	0	0	0
+6300	PF06472	ABC_membrane_2	Ald_N; 	ABC transporter transmembrane region 2	Yeats C	anon	ADDA_6479	Family	This domain covers the transmembrane of a small family of ABC transporters and shares sequence similarity with Pfam:PF00664. Mutations in this domain in Swiss:P28288 are believed responsible for Zellweger Syndrome-2 [1]; mutations in  Swiss:P33897 are responsible for recessive X-linked adrenoleukodystrophy [2]. A Saccharomyces cerevisiae homolog is involved in the import of long-chain fatty acids [3].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.51	0.70	-5.28	26	2221	2012-10-02 13:23:42	2003-07-14 14:08:31	10	15	1284	0	895	2380	1271	271.60	24	45.53	CHANGED	hphsssFhpplhpLl+lhl.PphhspcshhLhslshhLlhRThlslhluphsuplhpsllp..............pshctFhhtlh.pahhlulssohlsshlcYhpscLtLpaRppLocalaspYLpsp.saY+huslDs....plsNsDQplTpDlppFs...........s.ssusLaoslsKPllDlhlasapL....hpssGttus..............hhlhsYlhhuus.ll+tlssPhucLssccp+hEGcaRahHsRLlsNuEEIAFYpGpchE+pplpppapsLlpphptllph+hhhshh-shlhKYhhsslGallsulPhF	.................................................h........phh..l.hp.hh..s..p.t..hpt.............hh.h.....l..............h..h..l..hh..h........h.l...h..ts.h........l.s....lhls..p.hs.....s.phh...s.u.L....p....................................................................p.sh..ptFh..p..hlh....h............a.......h...........h.............lhh...hh.....s..h.h.s................s.....h..............h.......pa........l.p....p.h.L....tl.pWR....phLTcth...hsp.ah...............s............s....p...s........YY+l..p...h..hsp.........................t.h.-.N.P................DQ....RIspDlpths............s.sshsLh........h........s...l.lpsllsll...hFshh.L....aph..uG.shsh.......................................hhhh.l...ashhu..sh...l.h.......p............h.lu..p...................lhpLshppp............+hEusa.........R...hshs+lpcp.......uEpIAh........ap..G...c...p.h...............Ec...p...............pl...pppFps.lhpsh.....pp.......l.......hptp..hh.......h.......shhpshh.....phhhshhshllhus.h...................................................................................	0	255	477	704
+6301	PF06473	FGF-BP1		FGF binding protein 1 (FGF-BP1)	Moxon SJ	anon	Pfam-B_14221 (release 10.0)	Family	This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development [1]. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2 [2].	25.00	25.00	41.80	25.60	20.00	21.60	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.86	0.70	-4.76	9	118	2009-01-15 18:05:59	2003-07-14 14:09:56	7	2	40	0	70	108	0	192.60	24	96.26	CHANGED	lphLohL.LLlsthhhspstK..psKstptussppt.p...s...............pG+FsTK-pssCoWtl...hpts.pslsL+VcCpptsps.....asCtasGpPppC.tapscsptYWKQlsppLR+p+phCpssp.lLKoRlC+Kssspuph.................+hlopsh.ssptscpchppssspcpstsptpss.cpp........t.ttshssphPch.s.....psss.tppp+hAhEaCsEoWpSLCsFFlshhpG	..........................................shl.hLhs.hhhsthtp......t.cttttpt....stt..............................pG+F.op.c....p.t....sCshth.............pt.t.tthpLplpCp....p.....spp.......a.C.atGpPp.C.tatsp.phYW+QlhttL++.+.phCpsst.sL+splCp.+.ts...puph...................phhspsh.st...t....sppp.......tt...t...st.....t...........t................t.............t...t...hh.s.......s.ph...............pss.s...p..ptchs.paChcpapSlCsFFlshhps...............................	0	3	11	31
+6302	PF06474	MLTD_N		MltD lipid attachment motif	Yeats C, Bateman A	anon	ADDA_7289	Motif	This short motif is a lipid attachment site.	25.00	25.00	25.10	25.30	23.40	24.20	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.45	0.72	-3.76	11	113	2012-10-01 23:27:00	2003-07-14 14:17:28	7	3	100	0	15	67	2	26.30	54	5.12	CHANGED	Mp...................hsphuhlhh.sLLsGCQo	......................htVphShVhA.hLLVGCQS	0	3	3	9
+6303	PF06475	Glycolipid_bind	DUF1089;	Putative glycolipid-binding	Moxon SJ	anon	Pfam-B_14397 (release 10.0)	Family	This family has a novel fold known as a spiral beta-roll, consisting of a 15-stranded beta sheet wrapped around a single alpha helix. It forms dimers. It has some structural similarity to the E. coli lipoprotein localisation factors LolA, Swiss:P61316 and LolB, Swiss:P61320. Its structure suggests that it may have a role in glycolipid binding. Its genomic context supports a role in glycolipid metabolism [1].	25.00	25.00	28.10	26.80	22.00	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.00	0.71	-5.13	30	291	2009-01-15 18:05:59	2003-07-14 14:32:26	6	2	259	2	90	250	11	175.50	34	93.19	CHANGED	tslpWcsh...-ssGhEplpl....ppsusultssuhlh.sppsups.hulpYclpsDssWpo+phplsshhutt.tplpltp-tcGpWhh.sGp...shssl-GslDlDluhoPFTNTLPIRRLsLst..GpstplsssalphPshp.lshspQpYopl..ss....phY+Ycusstu.......AclsVDccGhVlDYPsLacRl	.........................t..lpWpsh....-.hsthEplpl....ph.ssptlpsputll..utpssps.auhpYclt.sDtshts+chslpshhutt..ppLpltpD..tcG...t.....Whs..tssp...............thsshs.GslDlDlshoPFsNsLPIRRLGLtp......ucst..slsVlYVslP.....-.....hs.VssspQsYosh.ss..............pth+acossss.......sslsVDs-GhVlDYPsLhcRh........	0	24	50	68
+6304	PF06476	DUF1090		Protein of unknown function (DUF1090)	Moxon SJ	anon	Pfam-B_14862 (release 10.0)	Family	This family consists of several bacterial proteins of unknown function and is known as YqjC in E. coli.	21.10	21.10	21.10	21.20	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.50	0.71	-4.42	40	769	2009-09-11 09:53:20	2003-07-14 14:36:26	7	2	736	0	83	307	8	111.90	51	89.98	CHANGED	slsshlsssshus...ttt..hsGCssKtpsIppQIphA+taGNpp+lsGLcpALppVpscCoDsuLtp-+ppKltc.tcpcVsERpp-LpcAppc.......Gcs.-KIsK+pcK..LuEAppEL...pcA	..............lu..AlsLhsl.S.uuohA.....sohCQcKEQsIp.KEISYAcKHpNQsRI-GLpKALSEVRANCoD...opL+A-HpKKIA.......c.pK-.......EVAERQpDLsEAKpK.......GDA.DKIsKRc+K..LAEAQ-ELKK.l......................................	0	4	19	50
+6305	PF06477	DUF1091		Protein of unknown function (DUF1091)	Moxon SJ, Bateman A	anon	Pfam-B_14929 (release 10.0)	Domain	This is a family of uncharacterised proteins. Based on its distant similarity to Pfam:PF02221 and conserved pattern of cysteine residues it is possible that these domains are also lipid binding.	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.23	0.72	-3.55	534	1212	2012-10-01 19:31:57	2003-07-14 14:38:56	8	13	19	0	714	1209	0	83.10	21	48.20	CHANGED	lphplhp+t.....ssacs.h.lashs.hDhCca...l...................p........hhphhaphhp..phS.Nh.scs....CPa...............stp....h..hlc.s.......hhhst......phlP.........l..P.pGp..Yhl	.....................................hhhp........ssac.h..las.hs.h-hCch...l..pp.....p.........p...s......hhphh..aphhp.....ph.o..N....h..scs.......CPh.........................pss..h....hlc.s.....hhhst..................phlP....h.PpGpYhh....................................	0	114	175	487
+6306	PF06478	Corona_RPol_N		Coronavirus RPol N-terminus	Yeats C	anon	ADDA_7507	Family	This family covers the N-terminal region of the  coronavirus RNA-directed RNA Polymerase.	25.00	25.00	84.40	84.40	18.70	18.00	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.25	0.70	-5.76	11	440	2009-01-15 18:05:59	2003-07-14 15:04:52	8	32	218	0	0	416	0	326.60	64	6.25	CHANGED	G.SSAARLEPC.NGT-sDhVhRAFDI....NKcVAslGKaLKsNCsRFppl.Dcc.......DuaFVVKRsTcSsh-HEQohYshLKsCsAVAcHDFFsa+cs+shhsNluRpcLTKYTMMDLsYALRpFDEpNC-lLKEILVhhGsCcpsY...F..-sKsWYDPVEN.DIaRVYApLGplVspAhLKsVtFCDsMVcpGlVGVLTLDNQDLNGsFYDFGDFlpshPGhGVPlssSYYSYMMPlhuMTNCLAuEsFhcuDl.upsaKsaDLLcYDFTEaKhsLFsKYFKYWs.pYHPNCsDCtDDpCllHCANFNsLFSTTIPsTuFGPLsRKlFlDGVPhVsTsGYHFKpLGlVaNpDVshHssRLS	.............SusARL.PCusGsssDVshRAFDIhN..ppsAGhupaLKsNCsRFQc......l....Dc.....c.....ss.L...DuaFVVKRsThosYp+EpshYphl....K........s........s........ssVApHDFFpFchstshlspIsRpcLTKYTMhDLsYALRHFDcpsC-sLKEILVpYus...Cc-sY....F.ppKDWYD.VENPcIhpVYt+LG.lVppALLpsVpFsDshV-tGlVGVLTLDNQDLNGpaYDFGDFlpsAPGsGVslsDSYYSYhMPllsMTcsLssEpahc.Dl.tpsa+paDLLpYDFT-cKhpLFsKYFKYWs.psYHPNCh-C.DDRCIlHCANFNlLFShllPsTuFGPLVRKlFVDGVPFVVosGYHaKELGVVhN.DVshHp.RLS..	0	0	0	0
+6307	PF06479	Ribonuc_2-5A		Ribonuclease 2-5A	Yeats C	anon	ADDA_8069	Family	This domain is a endoribonuclease [1]. Specifically it cleaves  an intron from Hac1 mRNA in humans, which causes it to be much more efficiently translated.	22.50	22.50	22.50	22.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.90	0.71	-4.29	32	447	2009-01-15 18:05:59	2003-07-14 15:15:02	7	36	256	47	292	416	4	126.20	36	13.94	CHANGED	c+LpFLpDVSD+hEhcsRcs.SshLphLEs.sutpVl..p.scWpp+lspshhssLs+a.R+..............YpssoltDLLRslRNKpcHYcEh.sccl+chlGslP-sahpYFspRFPcLLltsYpslt...phppcchFppYaps	...................................................................pcLpFlp.DVSD+hEhE.s...p................c..............u....s.......l.l.p...tLEp..s.......uptVl.......t..scWpppl.sts.l.h..s.sL.t....+.a...Rp.........................Ypuso.ltDLLRAlRNKpcHYcEl....P.........tcl..........p.p..............t............l...........Gs...l....P-..s.......a..hp...........YFssRFPpLLhp.sYpshp....thpp.-phFp.Ya................................	0	100	156	224
+6308	PF06480	FtsH_ext		FtsH Extracellular	Yeats C	anon	ADDA_8169	Family	This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes ([1]). It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In  Oenococcus oeni FtsH is involved in protection against  environmental stress ([2]), and shows increased expression  under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.29	0.72	-3.88	164	4553	2009-01-15 18:05:59	2003-07-14 15:26:04	10	9	3836	1	1188	3236	1943	99.30	18	15.13	CHANGED	hhlahllhlllhhlhhhh....................ttt....................pspplsa..opF.........h.phlp...psplppltlp...........tpph....................................................h.s.ttpsspthtshhhss....sth.pp.............ltpthtpt.slphssp.t	..................................................hlalllhlllhslhp.h.................................sssps.....................................sspplsY..SpF....................l.pplp.......pGpV.......c.plplp...........spphs...............................................................................................................s..pppss.......sp.....h.....ps....h...h.s.ss...........t.....pp..............L.sthhpt.slp.............................................................................................	0	356	719	981
+6309	PF06481	COX_ARM		COX Aromatic Rich Motif	Yeats C	anon	ADDA_8118	Motif	COX2 (Cytochrome O ubiquinol OXidase 2) is a major component of the respiratory complex during vegetative growth. It  transfers electrons from a quinol to the binuclear centre  of the catalytic subunit 1. The function of this region is not known.	20.90	20.90	21.40	20.90	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.97	0.72	-4.29	98	1360	2009-01-15 18:05:59	2003-07-14 15:39:44	9	4	1276	4	243	775	21	47.10	36	14.66	CHANGED	K....so.spsLs.tssYtpLu...pPSEppPVpaauoVpssLFpsllspahtttp	........KtS.spsLs.hssapcLA.........tP..SE.....h.......s....VpYFSsVcPsLFpslls+ahstt......	0	42	105	169
+6310	PF06482	Endostatin	Coll_NC10;	Collagenase NC10 and Endostatin	Yeats C	anon	ADDA_828	Domain	NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor ([1]). Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to ([2]).	23.20	23.20	23.70	23.90	23.10	22.80	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.15	0.70	-5.03	11	375	2009-01-15 18:05:59	2003-07-14 15:52:32	6	57	98	17	154	356	3	193.10	29	28.00	CHANGED	GsusGssshpohpsMlspu+phPEGsLlalh-cp-LYlRVRpGa+plhLsshsPlssss................................PPsshhh........................................s...t.hhspP.phsphp...................ts.hhppsPtPssssss...cscpp.tPsLHLlALNsPhSGsMRGIRGADFpCFQQARssGLtGTFRAFLSSRLQDLYSIVRRADRtslPIVNL+D-VLFsSW-ulFoGutu.hpsusRIaSFDGRDVLpDssWPQKhVWHGSsscG+Rhs-oYCEsWRTsspusTG.ASSLt.uG+LL-QputSCpssaIVLCIENSFMTptpK	.............................................................................s.............................................................................................................................................................................................................................................................L+hhALNtP..s.G.sh......p.............AD....h.CapQucthGh..hs....T.a+AFLSS......+lQsL.plVp.s-R..thPllNh+splLF.sWpshFs.s.p.......t.u..h.....p..t..laSFsG+slhtcstWP.K...lWHGS.s...tG...R........ppaCcsW+stt....h.u.uu.l.............s............t..hl.t.Q..p.........t..CttthhlLClE.............................................................	0	36	49	101
+6311	PF06483	ChiC		Chitinase C	Yeats C	anon	ADDA_8334	Family	This ~170 aa region is found at the C-terminus of Pfam:PF00704.	20.50	20.50	22.50	20.50	18.90	20.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.05	0.71	-4.54	20	239	2009-01-15 18:05:59	2003-07-14 16:00:39	6	10	178	0	35	173	3	178.60	51	18.04	CHANGED	EYhMGsThTohhY-KFssA.oPYG.sp.tushshPspulDlslshosFtlGDsNYPIsPclplTNNSssslPGGochpFDlsTSsssphpD....QSGhGlpVlsSGps.sGsNlGGL-s-FHRVuhoL.....PuWpoLAPGuoh-lshsYYLPlSs.PSNasVshsGppYulpt-aPpLP...hss.suuGs......G	..EYthGsTMTphhY-KFpsA.oPYG.s+...hussshPspslDlsVslsuFplGDpN.YPINPKlsFTNNoslsIPGG..ocFpFDlPsSusDssKD....QSGuGLKVIsSGHT.pusNlG.GLcGshHRVAhoL.....PuWcoLPAGuoY-lDMVYYLPlSG.PuNaoVplssppYuhph-..PsLPss-.hsssGss.ss...........	1	10	16	28
+6312	PF06484	Ten_N		Teneurin Intracellular Region	Yeats C	anon	ADDA_8545	Family	This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional  regulatory activity ([1]). The length of this region and  the conservation suggests that there may be two structural domains here (personal obs:C Yeats).	20.20	20.20	27.90	38.40	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.21	0.70	-5.34	4	409	2009-09-11 06:34:01	2003-07-14 16:08:25	7	28	37	0	154	368	0	172.60	36	11.44	CHANGED	RSLTp.RpDTE+RYTSSSADSEDuKls..KSYSSSETLKAaDpDSRhsYGsRVKDhVH+EsDEFSRQGssFoL+-LGhGEssPsHhusYRoDMGLPHpsYSlSsuSDADTETDGlMSPEHAVRLWGRS.TKSGRSSCLSSRANSNLTLTDTEHENTEN..........................GPPLHCSSASS.SPl-QhP....PPPS.AANpsQttLLGsS.....uApsupDS-SE-EFuPNSFLVKosSGNlhsPttAsup..ssaQNHSRLRTPPLPLsHsHoPS..HHsASINSLNRuNYTpR.SN...PSPAPTDpSsssEsPsu.Q-SlpsQDNWLLNSNlPLETR.................................HFLFKPG.GTSPLaCTTSPGYPLTSSTVYSPPPRPLPRNTFSRPAFsLKKPYKaCNWK	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................shp.t............p....................st.........s.hppsWlLsSNhsLEo..R..........................................................pFLFK.u.Gooshhssss......sY.shsosoVYosPsR.LPRsohs.R.hFphpKs.+hCsW+...................................	1	7	22	53
+6313	PF06485	DUF1092		Protein of unknown function (DUF1092)	Moxon SJ	anon	Pfam-B_14522 (release 10.0)	Family	This family consists of several hypothetical proteins of unknown function all from photosynthetic organisms including plants and cyanobacteria.	20.10	20.10	20.50	31.90	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.74	0.70	-5.44	37	156	2009-01-15 18:05:59	2003-07-14 16:19:01	6	2	107	0	74	169	167	260.20	36	87.46	CHANGED	WELDFYSRPll-pcGKKhWELLIssssps........FcaschCPuscVNShWLpsALpcAltt........uhttPp+lRsaRspMpohlp+AspplGlpshPSRRTauLhcWLpcRpcplYPpp.GY.s..hssss.sh.tssPhPLP-ulpGDp...WsauuLshuslp-ht.-W...slsFss....lhPls....hsLss-........t.lPGlhlFSppRuLsLAuWluGLEPspLphpss......pLlLEuG.sD+Wlluslp.sspspttupsapps+ppupGLpFlulQssPpspsFsGFWlLc-	...........WELDFYSRPllDtpGKKhWELlIC-ssts........hpasphCPssplNShWLppAlppshtp........uh.hPpplRhFRspMpshIp+Aspcl.....ulpshsSRRThuLhpWLp-R.pplYspp.Gapt.....ts.ssls..hsp.ssPhsLP-sLhG-p...Ws...FlsLshuslp...-...h....-h...sls.Fup....hhPls....hsLsss........shIPGlhlaSs.RuhsLAuWhuGLE.stLphpss.............tLlLEsGhs-+Wllushp..sspstt....tApsaEpsKptupGLHFLulQs.sssupsasGFWLLpp...........	0	17	55	70
+6314	PF06486	DUF1093		Protein of unknown function (DUF1093)	Moxon SJ	anon	Pfam-B_15034 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.50	21.50	21.50	21.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.50	0.72	-3.62	59	1369	2009-01-15 18:05:59	2003-07-14 16:22:07	6	2	510	4	84	672	2	79.20	26	65.84	CHANGED	sshhttcshYspIsss...ucppspp.............tpYpYphpuaccsGcc+plpa...sus.....+pL+psuYLKlphpspp..........VpsacEVpcc-	.............................shhttcshYsplsps........upchsp..............pthpYphsuasccGcccplpasus........ppL+.pssYLKlhh....ps+c............Vpsa-Elpcc..................................	1	23	44	63
+6315	PF06487	SAP18		Sin3 associated polypeptide p18 (SAP18)	Moxon SJ	anon	Pfam-B_15078 (release 10.0)	Family	This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides [1]. SAP18 is also present in the ASAP complex  which is thought to be involved in the regulation of splicing during the execution of programmed cell death [2].	20.80	20.80	20.90	21.60	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.62	0.71	-4.31	26	277	2009-01-15 18:05:59	2003-07-14 16:37:32	7	8	228	5	202	279	0	126.60	42	57.63	CHANGED	t.t.lDRcpTCPhLLRlF.hppspaasls-as............................splP.tsELQIYTWhssTLRELspLl+-.....s..ssR++GTphsFtllaPDt+p.........upYls+-lGoshs..Gt+ss..................................D-sKTLpst+FpIGDalDluI	...............................s...lDREKTCPh..LLRVF.hp.sGpHHph..s.-Fs.....................................t....uslP.psELQIYTW.......hDuTL+ELosLl+-............shstsR++GT+hsFslVaPDh+p..................stahh+-lGsshs....Gpcss........................................................................D-s+TLtsh+FpIGDYlDlAI..................................	1	70	107	158
+6316	PF06488	L_lac_phage_MSP		Lactococcus lactis bacteriophage major structural protein	Moxon SJ	anon	Pfam-B_13945 (release 10.0)	Family	This family consists of several Lactococcus lactis bacteriophage major structural proteins.	20.20	20.20	20.20	31.10	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.74	0.70	-5.36	2	78	2009-01-15 18:05:59	2003-07-14 17:14:50	6	6	55	0	7	54	0	214.50	62	72.90	CHANGED	MKLDYNSREIFFGNEALIVADMsKGSsGKP.FoNHKIVTGLVSVGSMEDQAETNSYPADDVPDHGVKKGATLLQGEMVFIQTDQALKEDILGQQRTtNGLGWSPTGNWKTKCVQYLIKGRKRDKlTGEFVDGYRVVVYPHLTPTAEATKESETDSVDGVDPIQWTLAVQAT-SDIYLNGDKKVPuIEYEIWGEQAKDFsKKMESGLFIhQPDT.LAGtlTLVAPslsNVpTtTKGNNDGTIVlPsTLKsSKGpsIKVTuVIKDs+GpVATNspLAPsVYIVTFSA-GYtDVpAGVuVTs+s	.........................................................................................................................................................................................................................................................................................................LAGsl..TLVAPshs.s.sTTus.KGssDuThslPsTLKDScGusVtVTSVIpsupGpssTN.GpLusGsYhVTaSA-GY-DVTtulsVTD.....	0	2	2	2
+6317	PF06489	Orthopox_A49R		Orthopoxvirus A49R protein	Moxon SJ	anon	Pfam-B_14072 (release 10.0)	Family	This family consists of several Orthopoxvirus A49R proteins. The function of this family is unknown.	25.00	25.00	79.10	78.80	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.21	0.71	-4.26	2	38	2009-09-11 15:19:44	2003-07-14 17:19:49	6	1	18	0	0	29	0	147.10	88	99.93	CHANGED	MDEuYYSGNLESVLGYVSDMHTcLASIoQLVIuKIETIsNDILNNsIVNFIMCRSNLNN........lYhh.c.pIY.......................aY+..................................................SpDlpERh.	.....................MDEAYYSGNLESVLGYVSDMHTELASISQLVIAKIETIDNDILNpDIVNFIMCRSNLDNPFISFLDTVYTIIDQEIYQsELINSLDDNEIIDCIVNKFMSFYKDNLENIVDAIITLKYIMNNPDFKTTYAEVLGSRIADIDIKQVIRcNILQLSNDIRERYL...........	0	0	0	0
+6318	PF06490	FleQ		Flagellar regulatory protein FleQ	Studholme DJ	anon	Pfam-B_13480 (release 9.0)	Domain	This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators that are involved in regulation of flagellar motility e.g. FleQ in Pseudomonas aeruginosa.  It is clearly related to Pfam:PF00072, but lacks the conserved aspartate residue that undergoes phosphorylation in the classic two-component system response regulator (Pfam:PF00072).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.16	0.72	-3.90	47	334	2012-10-01 22:20:39	2003-07-14 17:20:29	6	6	327	0	79	856	142	112.00	30	23.81	CHANGED	+lLll-ssspRppsLssILcFlGEp....sphhsssph.....tstthpsphpuhslhhssss......ptlpsltpthsthPlLllGcpsts....phss......llGpl-hPlsYspLs-hL++sQh	..............+lLlI.-DD.upRRpsLssIL...c.FlGEp....spsh.s.u.p.ph.....sphshs.ssh.ps.h...h..l..h.st.ssp......thtphLp.pl..h..s...t..s..s..a.lPlLlhscps.s......chss..........................hlG.p...L-hPhsYspLp-.uL++sp.................................................	0	17	34	59
+6319	PF06491	Disulph_isomer	DUF1094;	Disulphide isomerase	Moxon SJ	anon	Pfam-B_14101 (release 10.0)	Family	This family of proteins has disulphide isomerase activity, EC:5.3.4.1. It has a similar fold to thioredoxin, with an alpha-beta-alpha-beta-alpha-beta-beta-alpha topology. It has a conserved CGC motif in the loop immediately downstream of the first beta strand. This motif is essential for activity [1].	25.00	25.00	31.10	31.10	19.30	17.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.67	0.71	-4.32	28	820	2009-01-15 18:05:59	2003-07-14 17:22:22	6	1	476	4	121	346	200	135.90	57	94.58	CHANGED	Y.cplVpPMRpELopuGFcELpTsE-V-pshp...p-GTTLVllNSVCGCAAGlARPAAstAlpp.-++PD+LVTVFAGQDKEATs+sR-.YF.hsaPPSSPShALhKDG-lVahIcR+cIEG+ssptIsppLtsAF-caC	.....YMpplVpQhRsElspuGappLpTuEsVcchhp...pcGTTLVhlNSVCGCAuGlARPAAspulph..-+pP-+LVTVFAGQDKEATs+hRE.YF.tshsPSSPSaALlKssclVchlcRHpIEG+-h.slhtpLpssF-c.C............	0	44	86	107
+6321	PF06493	DUF1096		Protein of unknown function (DUF1096)	Vella Briffa B	anon	Pfam-B_15011 (release 10.0)	Family	This family represents the N-terminal region of several proteins found in C. elegans. The family is often found with Pfam:PF02363.	25.00	25.00	26.20	26.20	18.20	18.20	hmmbuild  --amino -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.74	0.72	-4.01	10	23	2009-01-15 18:05:59	2003-07-15 10:07:56	6	4	5	0	23	16	0	53.70	49	14.66	CHANGED	pusslR-KRQ.uCGCA..ssQPoCuCQpusps.............QpSCSC.ps.QP.........ouCuCA	..t.usslR-KRQsCuCAP.spQPpCuCQ.psshs..s............tQ.sCoC.psssP.Q.......suCsCA................	0	6	12	23
+6323	PF06495	Transformer		Fruit fly transformer protein	Moxon SJ	anon	Pfam-B_13780 (release 10.0)	Family	This family consists of transformer proteins from several Drosophila species and also from Ceratitis capitata (Mediterranean fruit fly). The transformer locus (tra) produces an RNA processing protein that alternatively splices the doublesex pre-mRNA in the sex determination hierarchy of Drosophila melanogaster [1].	26.10	26.10	26.60	26.10	25.20	26.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.69	0.71	-4.40	4	112	2009-01-15 18:05:59	2003-07-15 14:07:55	6	5	25	0	9	111	0	154.90	62	79.37	CHANGED	MDADSSupp.RDoR..................RcuRpKE.KlPYFADElREpDRlRpLRpRtpppTR..............RoRSRSRSpSu-RssppRR+RpRSpsRp+Sto.........Rp+osSS....pRRRRpRS.pR.hs.sP+IIsh.V.VPstDa....YG.........hSuM.tuhsYth.PRP....PPa......PPhPFRYRt.sPFhstPRF	.............MDADSS.stp.R.D.TR.........................RRPRQRE....KMPYFADELRERDRVRNL.RKLKTT..QKR.TP..TPPPRERRSRpARoRSRSRTHSsEQSRCpRR.RSR.....SYV.....R.QRS..GS.........RH.Qo.SS.Ss.....sRRR+SRSRSR...RSRTPRIITVPVPVPAAEY.uYAYs..........h.........................................................................................................	0	2	3	6
+6324	PF06496	DUF1097		Protein of unknown function (DUF1097)	Moxon SJ	anon	Pfam-B_15055 (release 10.0)	Family	This family consists of several bacterial putative membrane proteins.	22.30	22.30	22.30	23.20	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.94	0.71	-4.38	53	1004	2009-11-03 13:31:05	2003-07-15 14:16:43	6	2	730	0	102	428	24	140.50	53	85.64	CHANGED	AlosGlLuulWshl...AsshsLs.sW.....sGFlussoaFAt.tsGhpGhhtohsoshoGlhWAhlhltuuuhh.sh......shhuhlhsulsshhMshtAph.phL.uFlPGsFlGssuTFAs..................ssshhhllsuLllGslhGashphhuthLhp	...................................AlTTGILSGlWuWV.....AsuLG...Ll.oW.....AGFLGCTuYFAsPpGG...hKGLhhShsT.hSGhVWAhlIIhuS..uhhspl........plluYll.TullAF..lMClQ...A....+p...h....LL.SF...lP.GTFIGsCATFAu..........................................tGsW...p..lVLPSL....hlG.hlFGYhMcsoGlaLu.t............	1	23	50	72
+6325	PF06497	DUF1098		Protein of unknown function (DUF1098)	Moxon SJ	anon	Pfam-B_15446 (release 10.0)	Family	This family consists of several hypothetical Baculovirus proteins of unknown function.	21.30	21.30	21.50	40.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.19	0.72	-3.93	22	51	2009-01-15 18:05:59	2003-07-15 14:19:53	6	1	51	0	0	48	0	97.70	30	85.45	CHANGED	ppp......ppsppsspsss............sssplLpuLsp...posAphIlsDsStsKpssLppLuppStsAK+llcuIps.sp-slpl.ss.cslslLcllsDIasNph	..............p......ppstps.ss.sp...........hssschLpsLNp...pTsAshIlsDso.sKppuLphLuppSssAKplL...-slps.ssssl+L.sshcslslLcllusIaDNph..	0	0	0	0
+6328	PF06500	DUF1100		Alpha/beta hydrolase of unknown function (DUF1100)	Moxon SJ, Bateman A	anon	Pfam-B_15719 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function. Members of this family have an alpha/beta hydrolase fold.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	411	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.38	0.70	-5.90	5	738	2012-10-03 11:45:05	2003-07-15 15:59:26	6	3	717	10	104	985	155	396.10	61	97.14	CHANGED	tsSKNLSETLFpsHKQAKETSoLTQYMPoSp..slLDsl-pcoupuWYRpLRRLQWlWQGlDPlEhE-VLARIASSKHSRTcD-WLDTVMGYRSGNWsYEWs+lGMhHQ++AsEcssE.sAu-phFsAALhYSIAGYPHLKuDNLAlQAQVLAN+AYpEAAK+osYTlKQLEFPapc.uKIoGaLHLPs.TDuPaPVVLVSAGLDSLQTDMWRLFRDYLAP+DIAMLTIDMPSVGaSS+WPLTEDSSpLHQAVLNpLsslPWVDHaRVGLlGFRFGGNAMVRLuFLEs-KlKACVsLGAPVHDLFoSPcKLQpMPKMYLDVLASRLGKusVDlcSLuGQMsAWSLKVQGFLSGRRTKTPILAhuLEGDPVSPYSDNQLVAhFSssGKAKKIsSKTIocGYEQSLDLAIcWLEDELp	..................................................................................................MoQANLSETLFKPRF..KHsETSTLV...RR...h..s+..Gup..sslQ..S..A...LDG.c.olsHWYRMINRLMWIWRGlDPpEIL-VQARIVMSDAERTDD-LaDTVIGYRG...GN...WI.YEW..A....pQA....M.s...W....Q...Q...KA....s...t....E....p....D....s....hoGR.a.W.LH.AAsLYsIA..A..Y......P...H.....L.....K.....G.....D...-....L....A....E....Q..A....Q....A....L.....u.....N.......R...A....Y.E....E...AA....Q..R..L....P.Go...h..Rp..h.EF.s.....l.........P......G.....Gu......P..........I..T..G....F......L......H.....M...P........K.......G...............D.....G......P...F....P....T.V.L.M..C.GG....L.....D...u..h.....Q....T...D.......Y.......Y......s...L....Y....E...+...Y...FA.PRGIAMLT..ID.........M.........P....S...........V..G......F.......S........S.....K.......W....K.....L.....T.....Q.....D....S....S..l..L.....H.....Q.....+.....V.....L...+....A....L....P....N..V......P.......W......V...DH...TR..VAA.FGF.R.F.GA.NV.A.V....R.LA..YL.E.u.s...R......L...KAV.A..C......L...GP...V...V...H...s..L...LS....D.........p....pQ.....p....p.....V.....P...E.....M.....Y....L.DV...L..ASRL.GM.H...D..A..S......D-.A.......L..R.VE.L.N...RY.SLKVQGLL..G.RR...CPTPM.LSGaWKNDP.FSPEED.SRLIToS.SuDGKLlEIPFsP..V.Y+..NFD.+uLpEIocWIE+RLC..................................................................................................................................	1	16	42	73
+6329	PF06501	Herpes_U55		Human herpesvirus U55 protein	Moxon SJ	anon	Pfam-B_15779 (release 10.0)	Family	This family consists of several human herpesvirus U55 proteins. The function of this family is unknown.	20.40	20.40	20.40	21.40	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.53	0.70	-5.91	3	7	2012-10-03 01:18:03	2003-07-15 16:04:15	6	1	5	0	0	51	0	426.60	42	95.40	CHANGED	oS-Ls+llQlslDaN-.lQuc.Nao.lhlcCllS+T+PVLLLITDGTEScsEDVhFsu+sLcccpsIKI+lhPlsRoI.Ps+VplFulPIapIoSSLlIpD.shh..KENhDPpcaEQaGlhspsIuTTNlIs.lpsVpNcslElolTlFNIsWccSsYQsplccosG++LpTlaoVFSlNTspCPYWpshF+..SshPlC+VpMISEPsVSVYKIEFssPlLpVFLRshsLsspNsRFsVspEChLRLsF.ScPshsoVoLNlsMPYFKICuDtKslEVFFP-cMoLssNcsKcIsLRGTFpNhsAVGLFIPcposVlp.aPFlWpPpEoF+l+VoC-RospVTEHDIIG+VYFIo++lFR+sF+PsusuDhKSclEtspNoscsFclaFLGNcFFussLP-LTLHPhhshcYEclQusuNIpp.s.NcsPShpRlRl	.............................................................................ospLs+llQlshDhNc.l.sp.sap.lhlcChlSpT+PslLhITDGTEScsEDVhFssphLcpppsIKI+lhPlsRol.Ps+lplFulPIah.osuL.IpD.shh..KENhDPhhaEQaGlhshsIuTTNlIs.hpsVpNcslEholhlhNlsWpcSsYQsphhcp.G++LhhlaolFSlsTppCsYWpshFc..ShhPlC+VpMISEPslSlYKIEFssPhLplFLRshsLsppppRFslspEChLRLsF.S.PshsoVoLNhsMPYFK.IC.uDtK.slEVFFPscMoLs.NpsKcIsLRGpFpNhph.VGlFIP.spopVhp.aPFlW.spEsh+l+loC..-+.ospVTEH..DhlG+laFlo.++lFR+.sF..+shu.suDhKShlpt..spNo.scsFclaFhGNsF.u...L.P-LTLH.Ph.....cYEch.upuN.ph.s.scp.Shh+hRl.....................	0	0	0	0
+6330	PF06502	Equine_IAV_S2		Equine infectious anaemia virus S2 protein	Moxon SJ	anon	Pfam-B_15780 (release 10.0)	Family	This family consists of several equine infectious anaemia virus S2 proteins. The function of this family is unknown.	18.90	18.90	20.80	22.30	17.00	15.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.31	0.72	-4.11	2	41	2009-01-15 18:05:59	2003-07-15 16:07:45	6	2	2	0	0	41	0	65.30	75	83.19	CHANGED	MGlFGKGVTWSA.HShG.SQGE.QPL.PNpQpp.ohR+p.ha..N.IVIhhsl+ptWQppcpQ-TKK	.....MGLFGKGVTWSALHSMGV.SQGEYQPLSPNKQNQQTH+KtIhWYINPIVIMhAIKpKWQRQETQDTKK....	0	0	0	0
+6331	PF06503	DUF1101		Protein of unknown function (DUF1101)	Moxon SJ	anon	Pfam-B_15836 (release 10.0)	Family	This family consists of several hypothetical Fijivirus proteins of unknown function.	25.00	25.00	77.70	77.60	18.50	18.00	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.07	0.70	-5.64	5	109	2009-01-15 18:05:59	2003-07-15 16:10:46	6	1	9	0	0	40	0	317.00	82	99.67	CHANGED	M-RuoREHsKFSKANT+sEs+pMRhYKDDSsD-lsYSEIsVGlooooP+MuLSDYFSuVSloF-sEtRl-ElcPhlYuDLpF.p-pYspDVDLNLLlWQLLSuNQDS+ALCVNlLRMlsTluhGNAaIsc.GpY+Y.spsTs-pTss-DlDuLRlluRlAKIlIKsshsKsD.L+ssQcpLIpYapG+ua+SloLoWDSKSlLsolHGYS.TSEslLDaYIRpKL.DLFKuLpssNLVYGGNYpLVYQlLFYYYIlTNGRaSoGFosR+-S..IKoYslPNDsPusCNso.PRKPoLSLMaIRAlLlIsLIKDYSPlKplPlYlppLElEcPhpNoshlTDuGIRoEs-shssosslsts..LPsFSSsuu	..........................pEMRIYKDDTAsGLCFSEINVGCTSooPKMuLSDYFSSVSCSFDGEMRhPDlPL+hYGDLHF.H-QFTNDVDLDLLCWQLLSSNQDSRALCVNILRMlTuLSLGNAFISE.GRYHY.AlDTTEpTSAEDsDALRhLuRlAKIVIKNslcppD.lshAQQsLIYYYFGsSapGIHLNWDS+SSQ.SlHGYS.TSEsCLDHYIRMKI.DLFpGlRsKN.VYGGNYQLVYQALFYYYllTNGRFSSGFsVRKDS..IpSYFlPN-sPSsCNVo.PR.KPSLSLMFIRAlLlhhLIKDYSs.......................................................s....................................	0	0	0	0
+6332	PF06504	RepC		Replication protein C (RepC)	Moxon SJ	anon	Pfam-B_15903 (release 10.0)	Family	This family consists of several bacterial replication protein C (RepC) sequences.	22.80	22.80	23.30	23.50	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.98	0.70	-5.46	5	105	2012-10-04 14:01:12	2003-07-15 16:17:02	6	1	87	0	15	72	6	265.80	61	93.70	CHANGED	tscsAMsaDLTHARHDPAHCLAPGLFRSLKRGERKRLKLDVTYsYG-DcplRFsGPEPLGADDMRlLQGLVAlAG.....P+GIlLoPEPcSEuG+QLRLFLEs+WDAlEpDAMVVKGSaRpLASElGYATDGGusFKAIRESIERLWsVSVIVp+GuKRQGFRLLSEYASDEs-GRLFVALNPRIAEAIlGcRPHTRI-MAEVRALQTDPARLlHQRLCGWIDPGKSGRVELDTLCGYVWPD-ANuEAMKKRRQTARKALsELAAVGWTVNEYAKGKWEIoRPKPsu	..................................................................................................h.....pasLoHsRHDPAHCLAPGLFRuL...KR.....GER...K.RsKLDVT.Y.cYG-G.ccIEFsGPEPLGADDLRILQGLVAMAG......PsGLVLuPE.PpTEuG+.QLRLFL.....EP..K.WEAVst..D.AMVV.KGSYRALA+EIGhts.DuGssh..KtIp-CIERLWcVSI...IA..Q.....sG.R..K..RQ.....GFR...LLSEYASDEs.DG..RLYVALNPLIApAVMGG..uQHVRIsMcEVRALco-sARLlHQRLCGWID.PGKo....G+sslDTLCGYVWP.sE.A.su...uTMR...K....RR.Qp.lRcALs.ELs........A........L.GWTVsEaAtGKa-IsRPKssu..............	0	4	9	12
+6333	PF06505	XylR_N		Activator of aromatic catabolism	Studholme D	anon	Pfam-B_2890 (release 9.0)	Family	This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators in several proteobacteria, including activators of phenol degradation such as XylR. It is found adjacent to Pfam:PF02830.	20.80	20.80	21.00	21.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.09	0.72	-4.60	16	223	2012-10-02 19:02:47	2003-07-15 17:16:43	6	10	157	0	87	229	15	101.30	39	18.53	CHANGED	DLspplpFusp-GcIWLs-QRMLLlHsuuLuuLR+ELlpslGh-+ARGhhhRhGatuGtRDAclsRchRssusthshFhAGPQLHsLEGhV+Vpslph-....hDhp	.........DLpppLpFsspsGpIWLs-pRMlLl+ssuhu.s.LR+ELIcsLGh-pAR.......GlhhRhGYtu....Gh+DAcls.+chh.ss...s...s.hphFhsGPpLHsLcGhV.+VpslphchD..p.........................	1	17	50	76
+6334	PF06506	PrpR_N		Propionate catabolism activator	Studholme D	anon	Pfam-B_10794 (release 9.0)	Domain	This domain is found at the N terminus of several sigma54- dependent transcriptional activators including PrpR, which activates catabolism of propionate.	23.10	23.10	23.10	23.10	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.60	0.71	-4.87	47	943	2009-01-15 18:05:59	2003-07-15 18:17:36	6	25	691	6	118	633	15	172.70	37	30.19	CHANGED	plstchst.hclp..lhpsshp-ulphhcph.tt.ctsDlllutGu.sushl+ppl.slPVV.lpsouaDllpALtpA+....chs.....sclulVsappsh..u....hpphpphl.sl..slpthsapstc-scstltplpppG..hplllGsulsschA.pphGlpulLlhS.cpolcpAhccAhclsphtcpc...tp+	..........................s.l.hca-p.ssls...l.phsh-.cAls......hlcct..ts..ccsDsIIusGu.suuhLKs...+l..s.....l...PVl.I+sSGaDl....LpALsc.At.....c..hs........usIGlV.sa..ppsl..su....lhsapcth..sl.....clcpts.a...h....o.....c...E.-......uc....splp.cL+....usG..h-slVGuu.l.l...s.D.lA...cc..t...Ghs..u.lhl..hS..ssoVRpAhp-Alchschpppt....t..............	0	31	67	92
+6335	PF06507	Auxin_resp		Auxin response factor	Studholme D	anon	Pfam-B_2015 (release 9.0)	Family	A conserved region of auxin-responsive transcription factors.	21.10	21.10	21.70	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.66	0.72	-4.12	32	687	2009-01-15 18:05:59	2003-07-15 18:33:44	8	14	62	0	312	710	0	77.80	45	10.75	CHANGED	AupuhsstohFplhYpPRsosS-FlVshp+ahcuhp.p.aslGMRFKMtFEsEDusc++a...tGslsGls-hDPh+WssScWRsLp	...........................Au+AsussohFplaYpP....R........s.S.s.uEFllshs+ahc.uht..ppholGMRF+M..t.F.Es...E-.u.uc..+...........Ra..........hGTIsGlsD...h...D.P.h+WssScWRsLp..........................	0	40	196	261
+6336	PF06508	QueC	ExsB;	Queuosine biosynthesis protein QueC	Studholme D, Eberhardt R	anon	Pfam-B_715 (release 9.0)	Domain	This family of proteins participate in the biosynthesis of 7-carboxy-7-deazaguanine. They catalyse the conversion of 7-deaza-7-carboxyguanine to preQ0 [1-3].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.56	0.70	-5.05	33	3226	2012-10-02 18:00:56	2003-07-15 18:54:36	8	14	2983	7	768	3867	2443	199.30	40	86.40	CHANGED	+AlVlhSGG.DSTTsLhhApcph..hEVhsloFsYGQR.HptEl-sAcclucths.........l.c+cllDlshLpplu...sSuLTcssht.lsc....ph.t.....cslPsTaVPuRNhlFLSlAuuaA-slGupsIhhGVsppDaSGYPDCRsEFlcuhppslsLu......tsptlpI.psPLh.LsKu-IhcLutcLG......lshchThSCYpG......tcu.uCGcCsuChLRpcGapchs	........................................................................................................................................+AlVlaSGG.D.ST....T....C.L....h..h....A....h......p...p..a.......p..c....V..p.......sl..o....F.....s...Y....G...Q...R.....Hc..........t.......E...l...-...s.........A....c...p...l.....Apc.l.G.............l........p....H..+..l.....l....D..l..s....h...L.....s.p.....l.u...........s.suL.....T.c....cs.h.t...lsp...............tt.................ssl..P.s.Ta....V.P..u.RNhl...F....LohA.u.sh......A....ph....su...c......t......l...h..h...G.....V....s...p.....s..D.....a..S........G........Y...P.......D..C..R.....sp.......F..l....c..uh...p...t.sl.s.Lu............hspsh..p.l...cTPL..ha..l.sKA-hh...tLu.p...p.h.G..............hsh.pp...ThoC..YpG....................utuCGcCsuCpLRtpGhpphh....................................................................................................................................................	0	218	457	625
+6338	PF06510	DUF1102		Protein of unknown function (DUF1102)	Moxon SJ	anon	Pfam-B_16043 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	22.20	22.20	22.60	24.40	21.70	22.10	hmmbuild  --amino -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.95	0.71	-4.39	9	41	2009-01-15 18:05:59	2003-07-16 09:38:25	6	2	17	0	35	48	0	144.00	39	74.21	CHANGED	sIVoDDsELIDLTPlQPYuYl..ssGKLslDISssNP.NYPGY.GcGlSPsSpYsF-EhFsVSNcLWEs...shPIsVpIp.Spsstlphauu-h-s..ussG..........sslsFoVthsssVslGM.Fsssscs.G.s.ptplsIcAhthusE	......................sIVsDDsELIDL.sPlQPYAYl..ssGcLsIDlSssNP.NY.P.G...............Y............GpGlSPsSpYsF-EVFpVSNcLWEs............h.sI.....sVpIs.Ss...ssplphausshss..ssss...........sslsFsl..G-sVplGM.hsssGt.s.G.shptplsIpAhthtsp................................................	0	5	14	25
+6339	PF06511	IpaD		Invasion plasmid antigen IpaD	Moxon SJ	anon	Pfam-B_16150 (release 10.0)	Family	This family consists of several invasion plasmid antigen IpaD proteins. Entry of Shigella flexneri into epithelial cells and lysis of the phagosome involve the IpaB, IpaC, and IpaD proteins, which are secreted by type III secretion machinery.	25.00	25.00	26.00	25.60	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.21	0.70	-5.44	3	264	2009-01-15 18:05:59	2003-07-16 15:13:00	6	2	198	33	19	191	0	261.50	40	88.15	CHANGED	tNhouSssPulsAuRupssosGpuAEpVpAsVcoTTu..........a-TpcsIppSsAAhKtppuQQTLpcTPstEl-EsssppTluspphsusLNuLAKSGaulSAEQ+EsL+Ssh.....SAPspAchuGuPM.....AtstpsISDuELWDMISssIucIsDsYLGVYENVVusYTDFYQAFSDILSpMAGWISPGG.DGNoVKLNVDSLKuALooLKKcYo......NKcslLFPAQo.suGhpTuSEuEAcKWlKELGLPD......SCV.KAusGGYVVlVDMTPIssMlsDLsuLGSGoELELDNAKYQAWQSGFKAQEENLKNTLQTLTQKYSNANSLFDNLVKVLSSTISSCLETAKSFL	......................................................................................................................................................................................................h...p..tp.Lshlu+..pt..s..lstptp.p..Lp..............SAPp...p.s..hss..h..............lSctElWshlupsIssIs-..sYLtVYEslVusYTpaYQsFS.-.lLSp.h.uGWloPGc.DGNolKLs.VsSLKstlppL..lsKYs...............sp.La.....Pups.......h....s..sopt-A..p.pWlpELshs...............upl.ptpsuG......YVV......hlshs...PlppMlpsl....sul......G...u...s.......u....t..l........hss...Ac.YQAWpuuFpuQc-NhpsslQoLspKYSpANShaDNLlKVLSusISo.h-oAKsaL................................	0	3	6	11
+6340	PF06512	Na_trans_assoc		Sodium ion transport-associated	Vella Briffa B	anon	Pfam-B_16808 (release 10.0)	Family	Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of Pfam:PF00520 and, less often, one copy of Pfam:PF00612.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.87	0.70	-4.39	62	1005	2009-01-15 18:05:59	2003-07-16 16:03:13	8	31	158	0	361	1059	0	206.90	31	13.21	CHANGED	DsEhNNLQlAlsRIpRuhsalKpsltshhp.thht+h....pphst...........................cttsp.hph.hsphhtst...................pth.t........h.tsuhpph.....pppp.tshhh...Nsshsl........sVPI..........AssESDh-......p............---tsSppS..................................t--scc......chpt.....................sSpSEsSTlDhcss.....tEt............-th..sc.t--.h-....P-cCFs-sCh++aPsht.lDhspshhphWWsLR+TCapIVEHsaFETFIIFMI	..........................................................................................................................................................................................................................................DsEhNNLQlAlsRIp+ulsalKpplh....phhp....thht.p.p......tthtt.......................................p..pp..p...htp...h.tst..................................................p.ptt..................tht.suhp..t.h...................pp.p..hshht.....ssshsl....................sVPI..........A.suESDhEs.p......................................s--hsSpss............................................................................................................-tspp...............................................................ssSsS-......sSTl..Dht.s...t-..................................................................p.h......-.tp....-.........P-sCFs.-.............sC....h...........p......+a...C..tp.ls..h.ppuhG+.hWWsLR+TCapIVEHsWFEoFIlFMI.......................................................	0	36	56	189
+6341	PF06513	DUF1103		Repeat of unknown function (DUF1103)	Moxon SJ	anon	Pfam-B_16075 (release 10.0)	Repeat	This family consists of several repeats of around 30 residues in length which are found specifically in mature-parasite-infected erythrocyte surface antigen proteins from Plasmodium falciparum. This family often found in conjunction with Pfam:PF00226.	25.20	25.20	26.50	25.30	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.38	0.70	-4.94	2	22	2009-01-15 18:05:59	2003-07-16 16:04:55	6	6	2	0	3	23	1	120.30	56	36.58	CHANGED	KVLGEGDKEDVKEKNDGKKDKVIGSEKTQKEIKEKVEKRVKcKCKKKVKKGIKENDTEGNDKVKGPEIIIEEVKEEIKKQVEDGIKENDTEGNDKVKGPEIITEEVKEEIKKQVE-GIKENDTEGNDKVKG.EIITEEVKEEIKKQVEEGIKENDTEupDKlhG.EIITEEVK........EGlKENDTEsKDKVIGQEIITEEVKKEIEpQEEK	..........................................................................................................................................cl.....-p.pc...........hcc..pc..slKEpDTEsKDKVIGQEIIhEEVKcEh.....ctl+c.....NcsEsKDcVIsQEIlsE-Vpct.......t........	0	3	3	3
+6342	PF06514	PsbU		Photosystem II 12 kDa extrinsic protein (PsbU)	Moxon SJ, Bateman A	anon	Pfam-B_13782 (release 10.0)	Family	This family consists of several photosystem II 12 kDa extrinsic protein (PsbU) proteins from cyanobacteria and algae. PsbU is an extrinsic protein of the photosystem II complex of cyanobacteria and red algae. PsbU is known to stabilise the oxygen-evolving machinery of the photosystem II complex against heat-induced inactivation [1]. This family appears to be related to the Helix-hairpin-helix domain.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.15	0.72	-4.14	24	89	2012-10-03 02:11:09	2003-07-16 16:26:02	6	2	78	17	32	170	35	91.40	44	59.54	CHANGED	stsDtchst.hG..pKlDLNNusVRsFpphPGMYPTlAuKIlpsuP...YcsV-DlLslssLo-cQKpllccah-sFsVscPpssh.tG.DRlNsGlY	................sDtKlsschG...pKlDLNNuslRsFpphPGhYP............oLAuKIl....p....s...u...P....YcsV-DVLslsGLo-pQKpllcp.hc..pFsVTsPp.th..pG.DRlNsGhY..........................	0	10	23	30
+6343	PF06515	BDV_P10		Borna disease virus P10 protein	Moxon SJ	anon	Pfam-B_16237 (release 10.0)	Family	This family consists of several Borna disease virus P10 (or X) proteins. Borna disease virus (BDV) is unique among the non-segmented negative-strand RNA viruses of animals and man because it transcribes and replicates its genome in the nucleus of the infected cell. It has been suggested that the p10 protein plays a role in viral RNA synthesis or ribonucleoprotein transport [1].	25.00	25.00	27.40	61.40	23.90	17.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-9.98	0.72	-4.15	3	40	2009-09-11 07:51:39	2003-07-16 16:31:46	6	1	7	0	0	39	0	81.20	67	99.97	CHANGED	MSSDLRLTLLELVRRLNGNATIESGRLPGGRRRSPDTTTGTVGVTKTTEDPKECTDPTSRPAPEGPQEEPLHDLRPRPANRKGAAIE	...MSSDLcLTLLELlRRLNGsuTlESGRLsGGRRRSPDTTTGoIGVTKTpEssKEChDPTuRsAPcusQEEPhHDLRPRstsRKGAslE	0	0	0	0
+6344	PF06516	NUP		Purine nucleoside permease (NUP)	Moxon SJ	anon	Pfam-B_15961 (release 10.0)	Family	This family consists of several purine nucleoside permease from both bacteria and fungi [1].	21.10	21.10	21.10	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.80	0.70	-5.60	31	328	2012-10-01 20:25:13	2003-07-16 16:35:58	6	4	268	0	136	310	52	309.80	42	85.63	CHANGED	lssKVhIloMFE.........sEhpsWh-t.....sh.........s+sIslPGhs..assl+Cssc.ulCtlsTG.GphNAAuolsALshsspFDLo+TYaLlAGIAGlsPptuTlGSssWA+YsVpssLpaEIDsREl.....PssWsoGYhshsspp..PsphPsssYs..........TEVFpLNstLpshAhpLo+ssp..LsD.ossspshRtpYssts........AppsPtVlpsDshoucsaapGshLs-hhpsasclhTsGsGsYsoTupEDsAThcALtRhupsGhlDhsRlhlLRTuSNFspPssGto..uhcpLhpts....tGGhssAl-NlYpsGsslVcsIlspWsp.acsGlss	...................................ssKVhlloMFt............sEupsWl-p........hth.........scp.l.slPGLSs.YPslcCssp.slChlsTGhG.sNAAuolhALshSs+FDLp+T..........YFLlAGIAG.l-PppGTlGSAsWA.+.YsV-huLpa..-l...DsR.Eh.....Pt....sW..s.sGah..u...lss.......p.p..Ps..ppPs..h.s.at...............TEVFpLNspLtshAhuLo+s.lp..LtD.ospupAhRt+Ystts..........AspsPpVhpCDThousTaapGshLu-thpsWoKlhTcGpGsYCoTtpEDNAThpALpRuApsu+lDhsRlhlLRTuSsFDRP.hsGpo..uh-sLhshs.......GGFs.Ah-NhYpsGsslVpsIlspWsp.acpul.s...........................................................................	0	35	73	113
+6345	PF06517	Orthopox_A43R		Orthopoxvirus A43R protein	Moxon SJ	anon	Pfam-B_16577 (release 10.0)	Family	This family consists of several Orthopoxvirus A43R proteins. The function of this family is unknown.	20.90	20.90	21.70	53.10	18.20	20.10	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.45	0.71	-4.75	2	47	2009-01-15 18:05:59	2003-07-16 16:39:31	6	1	19	0	0	35	0	194.30	91	99.60	CHANGED	MMhKW.ISILThSIhPVLuYoSSIFRhH.sp-lELCYG+L.FD+l.N.VNIKY.P.aIPYRYNFINpTLTVDEhcc.NVhFT+u.FLKa+YuS.LssuLlVuLuspLKYNDlpC.VNVSChIKNLhTpTSTILTSKHhTYSL+RSpC.hIIGYDSIIWYKD.IsD+......YNGIYDFTAICMLIASTlIVhlYhhK+IKMN.	......MMMKWIISILTMSIMPVLAYSSSIFRFH..SEDVELCYGpLYFDRIYN.VVNIKY.P..HIPYRYNFINRThoVDELDD.NVFFTHGYFLKHKYGS.LNPSLIVSLSGNLKYNDIQCSVNVSCLIKNLATSTSTILTS.KHKTYSL.HRSpCIsIIGYDSIIWYKD.INDK......YNDIYDFTAICMLIASTLIVTIYVFKKIKMNS.......	1	0	0	0
+6346	PF06518	DUF1104		Protein of unknown function (DUF1104)	Moxon SJ	anon	Pfam-B_16082 (release 10.0)	Family	This family consists of several hypothetical proteins of unknown function which appear to be found largely in Helicobacter pylori.	25.00	25.00	27.50	28.70	24.80	24.10	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.06	0.72	-3.85	12	166	2009-01-15 18:05:59	2003-07-16 16:41:54	6	1	63	1	18	153	0	89.50	44	61.91	CHANGED	ADFSKposcELhphuuslssp-hsDhthElcKRhtchpht-u+pa+pph+pthpcphsphohc-tpca+ptl+cthpc.+l-shSscEtcchGl	....pDFSphsDc-LlchAGpV.ssp-llDY+hElpKRhctMst--pK.p.F+tph+chAcKNlupMS.cDac+h+c-l+cslcc.+hKsho.cEh+t.GL...............	0	4	10	18
+6347	PF06519	TolA		TolA C-terminal	Moxon SJ	anon	Pfam-B_16081 (release 10.0)	Family	This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function.  Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See Pfam:PF01024).  TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.19	0.72	-4.01	9	916	2012-10-03 21:09:15	2003-07-17 14:43:38	6	1	772	6	109	684	85	92.70	45	28.50	CHANGED	ssstpuGssGs-lspYuu.IpptIQp+hhcsssatGKsCslcI+LuPDGh...lhslps.uGDsslCpAAluA.A+ssKlPhsPos.sVYEphKshsLsh	....................................sstpsussu.u-l.ssYAupIpsAI..p..u....+....h.h.-....s....s.s.a.t.....G.K...p..CsL..+I+..L..A..PD.Gh....L..l....s...l...p...s..c....G...G...DP..A....LCpAAluA...AKhAK....lP..+P..P....Sp..sVYEh.aKsusLcF....................	0	13	34	72
+6349	PF06521	PAR1		PAR1 protein	Moxon SJ	anon	Pfam-B_16232 (release 10.0)	Family	This family consists of several plant specific PAR1 proteins from Nicotiana tabacum and Arabidopsis thaliana. The function of this family is unknown.	25.00	25.00	26.00	64.70	22.40	20.90	hmmbuild  --amino -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.18	0.71	-4.65	4	68	2009-09-11 00:11:32	2003-07-17 16:32:16	6	1	14	0	38	70	0	144.60	49	87.47	CHANGED	sIsCENLscsoCuFAISSoGKRCVLEKph+RSGEEsYTCRTSEIEA-KlpNaIETDECIpACGVDRpsLGISSDuLLEupFTpKLCSstChcaCPNIVDLYFNLAAGEGVYLP+LC-pQtGpuRRuMuEI+SSGl...............lAPuPtSpl...cssNhhhsPAhuPh	...lhCEpLst-sCAFuVSSSGpRCVLE+thhpsGpht.YpCpTSElh.s-..+.lppaIETDpClcACGVDRtoVG..I..SSDuLh.Es..pFopKLCSspCappCPNIVDLYhNLAAGEGlaLPcLCpspcsss.RRt.h.h-...hhSsu................hAsts....................................................................	0	3	32	35
+6350	PF06522	B12D		NADH-ubiquinone reductase complex 1 MLRQ subunit	Moxon SJ	anon	Pfam-B_16238 (release 10.0)	Family	The MLRQ subunit of mitochondrial NADH-ubiquinone reductase complex I is nuclear [1] and is found in plants [2], insects, fungi and higher metazoans [3]. It appears to act within the membrane and, in mammals, is highly expressed in muscle and neural tissue, indicative of a role in ATP generation [3].	21.50	21.50	21.50	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.32	0.72	-4.28	55	447	2009-01-15 18:05:59	2003-07-17 16:38:21	6	4	210	0	280	434	1	69.80	27	72.13	CHANGED	hp+P.plhPLhsslususshssh.lsR.hhtNP-VphsKcsp...........s-.hpcas.pp.pKahpspt.......-hhshhppt.sch	....................hcP.plhPLhs...hlususshAshhhhRhhhtsP-Vp.hs+psp....................s-shpcht.pt.hKhht.p........ph....p.............................................	0	82	142	207
+6351	PF06523	DUF1106		Protein of unknown function (DUF1106)	Moxon SJ	anon	Pfam-B_16281 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins found in Escherichia coli and Citrobacter rodentium. The function of this family is unknown.	21.10	21.10	21.10	80.30	21.00	17.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.02	0.72	-4.16	2	25	2009-09-10 17:00:18	2003-07-17 16:40:58	6	1	18	0	1	16	0	89.10	89	70.05	CHANGED	MASLWK+LFY.sGpRRRYFEptEHSFSIlCGRLRGIVlThKCSpGIIYLSIKVsPNNppHlhLYpKK-YlFDKLKElFPDEAIEFoIEYEN	MASLWKRLFYSSGRRRRYFEEGEHSFSILCGRLRGIVLTIKCSNGIIYLSIKVSPNNRNHVFLYHKKDYVFDKLKEIFPDEAIEFTIEYEN	0	0	0	1
+6352	PF06524	NOA36		NOA36 protein	Moxon SJ	anon	Pfam-B_16330 (release 10.0)	Family	This family consists of several NOA36 proteins which contain 29 highly conserved cysteine residues. The function of this protein is unknown.	25.00	25.00	39.60	39.50	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.43	0.70	-5.17	3	242	2009-01-15 18:05:59	2003-07-17 16:49:12	7	2	207	0	71	226	0	192.60	70	97.66	CHANGED	MPKKKTGsRKKAEKQRERcKEIRuS..sVDLA+HPCNAsMECDKCpR+QKoRAFCYFCNSVQKLPICAQCGKpKCMMKoGDCVlKHAGVYoTGLuMVGAICDFCEAWVCHGRKCLoTHACsCPLpsApClECERGVWEHGGRIFpCSFCpsFLCEDDQFEHQASCQVLEuENFKChSCNRLGQYSCLRCKsCaC-DHVRRKGFKYDKs.KslPCPKCGY-ToETKDLSMSTRSaKFGRQTpGtcS.DD-pGYGuYapNhuSscYGDstussYGYcuDDDE--.SusDYDEEpDtDDDDsE-sD-..TopNcG-c-sDstA	................................................................................p..+..+QKsRAFCYFCpulQRLPhCApC..GKsKCMhKo.GDCVlKHsGVaoTG...............L.uMVGAICDFCEAWVCHGRKCLooHACoCPLtDA........sClECERGVW-HGGRlF+CuFCpsFL...............................................................................................................................................................................................................................................................	0	24	28	49
+6353	PF06525	SoxE		Sulfocyanin (SoxE)	Moxon SJ	anon	Pfam-B_16349 (release 10.0)	Family	This family consists of several archaeal sulfocyanin (or blue copper protein) sequences from a number of Sulfolobus species.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.56	0.71	-5.03	6	66	2012-10-02 17:41:00	2003-07-17 16:56:28	6	2	39	0	29	130	19	176.80	30	82.35	CHANGED	IssllVlIlllGlulY............................s.sphshlSosooosoToooos...............PutlsLPYsSsNKTVFIhLsVpoous..tFNaNGTSsGphKIYIPAGWsVhVpFhNpESLPHNLslVQNsTshPNssslSuDGKIlhhVGsosSNYtssGISSGpoAsGlhssluAGhYWlACGIsGHAcSGMWssLlVSsNVTsPYslh	..........................................................................................................llhllhhuh.hh...............................s..t.p..o.s..sosps.os.tsot..................................sst.....hs.sss...p.+TV.lhlh.shss.us........hNasGoup...G....ph.....plhl..PA......GhsV......hlphhN.p.p.u.l..s.....Hshhl..l....s...s..s.t.h.P...s.....ss...slu.t...G+..I.....l.h..h.l.Gs...o.s...us..h..s...p.G.l....u.........Gpss...s.s.h...h.....sls...AGhYhlsCsIs.GHAtsGMWs.llVSsshp.P....t..........................................................................	0	7	14	26
+6354	PF06526	DUF1107		Protein of unknown function (DUF1107)	Moxon SJ	anon	Pfam-B_16434 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	25.00	25.00	47.30	47.20	19.90	16.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.83	0.72	-4.16	21	718	2009-01-15 18:05:59	2003-07-17 16:58:32	7	1	677	1	82	194	5	63.70	70	91.41	CHANGED	hRhFcpYpPpplA+aVKsLF+GplaIpGlGtFcFDpG+lLl..Ppps-ppphpshpEVNppIppLp	.MKIFQRYNPLQVAKYVKILFRGRLYIKDVGAFEFDKGKILI..PKV+DKhHLSVMSEVNRQVMRLQ...	0	6	23	51
+6355	PF06527	TniQ		TniQ	Moxon SJ	anon	Pfam-B_16755 (release 10.0)	Family	This family consists of several bacterial TniQ proteins. TniQ along with TniA and B is involved in the transposition of the mercury-resistance transposon Tn5053 which carries the mer operon. It has been suggested that the tni genes are involved in the dissemination of integrons [1].	25.10	25.10	25.10	25.10	24.90	25.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.10	0.71	-3.96	43	576	2009-01-15 18:05:59	2003-07-17 17:04:04	6	10	398	0	177	503	23	138.90	19	29.75	CHANGED	hLshp.lsh.hssEshsSahuRLAttp..shssh...................psahtc.hG..hshpslhpsp........sslstlAphuGhss...spLtthsh.................................spstspt....hpl..tuchlspphl...ptsp.hRhCPtCL.tpDhtt.......stttshhRhtWplsslpsCspHpshL	......................................................................................................................hh....h.sEsltSaltRhAhtp.......thts.h.............................t.phhtp.....hs......hs...ht..t.hhtst................t.ltt.l..u..t....h.....s..s.h.s.s.....spL.p.ph..sh.......................................hphtpt...............hph.......htth.h.sp..phh...........t.t...h+....h....CPhCL...............ptsah+.htWpl..s..hht.sCspHpshL...................................................................................................................................	0	27	90	129
+6356	PF06528	Phage_P2_GpE		Phage P2 GpE	Moxon SJ	anon	Pfam-B_15359 (release 10.0)	Family	This family consists of several phage and bacterial proteins which are closely related to the GpE tail protein from Phage P2.	20.90	20.90	20.90	22.30	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.97	0.72	-4.51	17	525	2009-01-15 18:05:59	2003-07-17 17:09:05	7	2	406	0	55	217	1	39.10	54	85.46	CHANGED	MADIAslFHWsPu-htsMoLsELhcWRE+AhhRSG.sss-	...MADIAsIFHWsPu-h.sMolsEllsWR-+..AhtRSGsscp.........	0	7	24	42
+6357	PF06529	Vert_IL3-reg_TF		Vertebrate interleukin-3 regulated transcription factor	Vella Briffa B	anon	Pfam-B_16154 (release 10.0)	Family	This family includes vertebrate transcription factors, some of which are regulated by IL-3/adenovirus E4 promoter binding protein [1]. Others were found to strongly repress transcription in a DNA-binding-site-dependent manner [2].	25.00	25.00	84.80	69.30	22.60	20.10	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.06	0.70	-5.47	2	48	2009-01-15 18:05:59	2003-07-17 17:13:27	6	2	37	0	24	43	0	293.00	70	72.99	CHANGED	SSsuYAQEIQKLSsSTsVYFQDYQoSKsslsSFVDEHEPuhVuuSCISVIKHSPQSShSDhSEhsSVEHTQtS.hQusCRSPENKF.lIKQEPlELE...REsR--RGoYpsSIY.sYMGooFshYSHSPPLLQVptSoSNSPRTSEsD-GVVGKSSDGEDEQQVPKGPIHSPVEhppVHAT.VKVPEVNsSALPHKLRIKAKAMQVKVEAhDs-a-uhQKLSSPhDh.uKRHF-LEKHGspshsHSShsPFSVQVTNIQDWSLKsEhWHpKELssKhQsuhKTGVVElKDssYpVSEuENLYLKQGIANLSAEVsSLKRhIsTQ.ISASDSt	......................................SSsAYAQEIQKLSsSTAVYFQDYpoSKus.h.suFlDEHEPohVuSSCISVIKHSPQSSLSDlSEsS.SlEHoQtS..shQusCRSPEsKFQhIKQEPhELEsasREsRDDRGoYpuSIYQNYhGsoF.s.GYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPVELKpVHATlVKVPEVNS..SALPHKLRIKAKAMQIKVEAhDsEa-uTQKLSSPlDMouKRHF-LEKHsssshVHSS.LoPFSVQVTNIQDWSLKsEHWH.pKE...LsuKhQsuh........KT.GV..........VEhKDsuYpVS-sENLYLKQGIANLSAEVsSLKR.LIsTQ.ISASDS....	0	1	3	6
+6358	PF06530	Phage_antitermQ		Phage antitermination protein Q	Moxon SJ	anon	Pfam-B_3979 (release 10.0)	Family	This family consists of several phage antitermination protein Q and related bacterial sequences. Antiterminator proteins control gene expression by recognising control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream [1].  	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.71	0.71	-4.56	4	887	2012-10-04 14:01:12	2003-07-17 17:17:27	7	1	490	0	56	475	2	118.00	44	91.35	CHANGED	hRDIp.V..........LERWGAWAtssptslpaSPIAAGF.KullPh+spsRP.CsDDDGhIIssshspLpp.psschhsLLlsYYl+G.St+AIA++pthScspItK+Lp+AEGhI-GsLSlhsVRL-hDthlctt	...................................................hRDIp.V..........LERWGAWAs..s...s.p...p.c.lsa.Ss......IAAGF.....KG.L.l.....P.....p...+....s.K..o.R..P.p.C..s.DDD...uh.l.IsuChAR.L.p.+....psp...ch.a-....LLlsY....YV.h.GhohhulAc+......+.....psS-.shItK..cLp+AEGhl-G.hL.hhLsl+LEMD..h..p......................................	0	7	18	33
+6359	PF06531	DUF1108		Protein of unknown function (DUF1108)	Moxon SJ	anon	Pfam-B_16830 (release 10.0)	Family	This family consists of several bacterial proteins from Staphylococcus aureus as well as a number of phage proteins. The function of this family is unknown.	25.00	25.00	32.70	32.70	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.83	0.72	-3.83	4	313	2009-01-15 18:05:59	2003-07-18 11:23:49	6	1	192	0	4	97	0	84.90	65	99.43	CHANGED	MYYKIG-lppKlIsVsGFDFKLtVhKpchuIpIpVhDhpsssIcuhhVsDENDLYhAhDlhpQuI.EWIEpNTDEQD+LINLVM+W	.MYYchG-lppKlIsVsGFDFKLtlhKpchuIpIpVhDhpsssIcuhhVsDENDLYhAhDlhpQuI.EWIEENTDEQDRLINLVMKW....	0	2	2	4
+6360	PF06532	DUF1109		Protein of unknown function (DUF1109)	Moxon SJ	anon	Pfam-B_17952 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.60	21.60	21.90	21.90	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.82	0.71	-11.38	0.71	-4.90	54	293	2009-01-15 18:05:59	2003-07-18 11:29:26	6	3	227	0	122	289	32	192.70	31	93.87	CHANGED	LusshpPlpthshspphuhuhhsuhssuhllhhhh..hGlRsDlspshtsshFahKhuhshsLulsAhhssh+LuRPs.uptttthhhlslshshlhlsuhhplhss.sssthh.shlhGpshh..hChhsIsllulPshsuhhhulRp.hAPoc.thAGAsuGLsAGuluAhsYuhaCs-sussFlulWYsluhhlsuhlGAllGsRlLRW	.............................................LssphpPVpphshtphhhhshlhuhs..sussl.hhh..h..h.G.h.R.s...Dlsts.h.t.s.shF......hhKhshs..hhlussuhhshhtLuRPt..ptshh.hh.hl.sls..hsslhh.uuhhphhts....sst.sh..shlhG.tshh.......hC.hhIsllSlPsh.suhl.hulRp.hAPs+PslAGhsAGLsuGuhushl.Yu.haCs-suhsFlulWYslulshssslGAlhG.hhLRW.........................	0	29	59	86
+6361	PF06533	DUF1110		Protein of unknown function (DUF1110)	Moxon SJ	anon	Pfam-B_18243 (release 10.0)	Family	This family consists of hypothetical proteins specific to Oryza sativa. One sequence (Swiss:Q943P1) appears to be tandemly repeated.	24.10	24.10	24.20	24.40	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.21	0.71	-4.48	6	38	2009-01-15 18:05:59	2003-07-18 11:34:57	7	3	6	0	21	23	0	156.90	35	84.03	CHANGED	MAAE..AWRuRFRcRVsEAAp...RhEsVcEsLAsAhsHL...susMlAuD..tAAAARsRIQLAhGtLt-ASpsLA.AMSlMpuAcLLsh+.Gs.hs..h.httIupLGDp....YLAE+sAshKL+tAtcDAc-AastVDtCRGHLDAlLLLLDH.s+LPuVsshI-pERh.AAsuDLpAAIGpschGsEhAVsARQDVSG	...............c...sW+shF.pRVs.sst...phctlpt.Ltss..tl.....s.h.s..........Asssts+h....ttL.pASppLu.AhuhMtuAcLLAh+..Gsu.....sstt.hs....slspL....sDp....hh....s.ppAhh+LptAtpcAccAastl-tCRGHLsAlhhLLc+....thssVpshlptEhh.sAss.LpsA.............................................................	0	0	1	13
+6362	PF06534	RGM_C		Repulsive guidance molecule (RGM) C-terminus	Moxon SJ	anon	Pfam-B_18263 (release 10.0)	Family	This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum [1].	21.60	21.60	21.60	21.60	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.40	0.71	-5.09	23	234	2009-01-15 18:05:59	2003-07-18 12:07:50	8	6	64	0	115	193	1	170.90	49	43.56	CHANGED	Cs-QKlYpApoD-..LPuAFsDGopsGG-............psspoL...........cIhEpssG...pHVEIpA+YIGTTIlVRQlGpYLThAlRhPE-lspshp.-ppDlp..LClpGCPtsppIDhpphhtps.....................t.st......shshc....sAps+C+-p........hsVpDhYFpSCVFDLLTTGD...ssFThAAhsAhcDsctLcPspp..+h+l	.................CsDQKVYQApsD-..LPAAFsDGSpsGGD...........ttsusSL...........pIsE+ssG...pHVEIpA+YIGTTIlVRQlG+YLTFAlRMPE-lspuh-...-ppsLp......LClpGCPhsppI-hpthptps.......................s......s..sash-....oAps+C+Ep........LPVEDlYFQSCVFDLLTTGD...sNFThAAasAL.EDl+hL+sspc+hH...........................................................	1	17	28	67
+6363	PF06535	RGM_N		Repulsive guidance molecule (RGM) N-terminus	Moxon SJ	anon	Pfam-B_18263 (release 10.0)	Family	This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but Swiss:Q8JG54 from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum [1].	24.00	24.00	24.30	24.00	21.50	23.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.31	0.71	-4.23	14	210	2009-01-15 18:05:59	2003-07-18 12:35:16	7	4	61	0	111	164	0	164.30	57	41.22	CHANGED	C+lp.+Csupaspsp.p.s..htt................sstaCpuLRsYshChpRTARsCRGs..LsYHSulptlpcLhppaNCScsusTsps....................s.tsss.csCsY....................sp......apaCGLFGDPHLRTFpccFQTC+VpGAWPLIDNpYLsVQVTNsPVs.GSs....ATAToKlTlIhKs	...............................................C+I..+Csu-ahusTut.ps.hh.s.s......................ss-aCpALRuYAhCT+RT.A.RsCR.Gc..LsYHSAVhGIcDLMsQ+NCS+-GPTSps.......................................s..ptpsss-.C..pYcpp.......................httcsssPs......YhHCGLFGDPHLRTFpDcFQTCK......VpGAWPLIDNsYLsVQVTNsPV.lsGSu....ATATsK...lTIIFKs.......	0	14	25	63
+6364	PF06536	Av_adeno_fibre		Avian adenovirus fibre	Vella Briffa B	anon	Pfam-B_16053 (release 10.0)	Family	This family contains avian adenovirus fibre proteins, which have been linked to variations in virulence [1]. Avian adenoviruses possess penton capsomers that consist of a pentameric base associated with two fibres [2].	24.90	24.90	25.00	82.70	18.50	24.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.38	0.72	-4.29	6	42	2009-01-15 18:05:59	2003-07-18 14:02:22	6	1	6	6	0	36	0	96.10	66	20.54	CHANGED	YhsSGsusLppaTA+u.NSSs.uFsCAYYLQQW.opGLlhoSLYLKLDpsphushPostsspNA+aFTFWVuua.pphN.StIpssTloPSTsphss	TFVSGSsSLsoYNAshVNSSupsFSCAYYLQQWNlQGLLhTSLYLKLDSsTMGsRPGDhsSsNAKWFTFWVSAYLQQCNPSGIQAGTVSPSTATLo...........	0	0	0	0
+6365	PF06537	DUF1111		Protein of unknown function (DUF1111)	Moxon SJ	anon	Pfam-B_16636 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	499	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.50	0.70	-6.22	6	817	2012-10-03 10:02:11	2003-07-18 14:21:28	6	16	490	0	304	843	222	260.40	28	76.15	CHANGED	YTcloA.GGcTT.TFDASsSG.HGFSTPAsNLssspLA.HLpGDtpFETuFTTAPNuEH......PELDGLGPVFNNADCNSCHQRDGRNSTPpluuGpsRVKLGS-....AGIFLRIStAsspsChpG...oAsNNYCAPIsVPsFGuQLFH......RGVLpARsDWQpN.FhGQADVYLSYEhpoVoYs..........DGopVoLKKPlFpVENPYDAPGEoctSsNlTSsLLQsDVL......................MGWRNGMPVFGLGLLEAIuEAsILAhVDEsDoNpDGISGRANaVFDAlKAQuGDspPVSLGRFGWKANTPSVRVQSLGALRGDhGITNPLF..P-ESItGTuLHDSYLTRTGFVDTGss.sGtPEASAEFSDs....VVFYAETLAVPARRNVssspVREGA+LFsQlNCouCHsPoFsTKsSG-..lGGhPMs-uLKGQTIYPFoDMLLHDMGEGLADuRPDFLAoGsEWRTRPLWGIGLTQTVNPQAGFLHDGRAATLEEAILWHGGEAptSppsFMuLops-RuQLlsFLMSL	............................................................................t...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...............h.h..a.t.l...usP..t.c................t................h................t................t.....t.s......GtthF..p......htC..CHhsp.h.T......................................................................p............l.P.aoDhllHDhG........t..h..........sD...........t.............h..............p...................s.....p....ut...........a.RTsPLWG....hG....h..............................t.....................s...t...t....h.L.HDGRA.csh.EA..lhWH.......u.....G.............-ut......utp.h.t.hs.tpRttlltFlpu.......................................................................................	0	99	179	252
+6368	PF06540	GMAP		Galanin message associated peptide (GMAP)	Moxon SJ	anon	Pfam-B_16759 (release 10.0)	Family	This family consists of several galanin message associated peptides. In rat preprogalanin, galanin is C-terminally flanked by a 60 amino acid long peptide: galanin message-associated peptide (GMAP). GMAP sequences in different species show high degree of homology, but the biological function of this family is unknown [1].	20.40	20.40	20.40	35.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.01	0.72	-4.25	6	53	2009-01-15 18:05:59	2003-07-18 14:33:41	6	4	37	0	24	47	0	56.90	53	47.48	CHANGED	GKRELpPE.--h+PGuhDRsluEsNlVRTIlEFLoFLHLKEAGALDpLPslP.AtSuEDspcS	...GKRELpsE.--h+sG....uhc.Rsls.-sNIVRTIIEFLoaLHLK.Es...GAL-pLP....sh..SsE-ht..................	1	1	3	7
+6369	PF06541	DUF1113		Protein of unknown function (DUF1113)	Moxon SJ	anon	Pfam-B_17933 (release 10.0)	Family	This family consists of several bacterial proteins of unknown function.	19.70	19.70	20.10	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.08	0.71	-4.47	52	996	2009-01-15 18:05:59	2003-07-18 14:35:25	6	5	523	0	214	836	24	148.40	27	59.94	CHANGED	hhhFhlYSFlGWlhEsl...asu.lpc..++al.NRGFLhGPhCPlYGhGulhll...hhLtthpp..........shhhlFlhuhllsoslEYlsuallEplFpt+.aWDYSchhhN.........lpGRlCLhhSlhWGlhullhlchlpPhltphlphlPhhht.hhlshllhlhhlhDhlholh	..........................................................hhFhlauhlGWhhEsh....a...ss....lpp.......tc.ah....tcGh..Lh.G.P....hs...P...lY.GhGslh..lh.......hh..lp.hpp.....................shhhl.alhu...hllso...slEYlouhhlEt...hF...p.hp...hWDYSs.h...hN.........lpG..p...lsL.hulhW.Glhull....h...lphlpPhl..ph.h.t...h.l....h.hh...hhshhhhhhhhhDhhhoh.h........................	2	87	144	175
+6370	PF06542	PHA-1	DUF1114; 	Regulator protein PHA-1	Vella Briffa B, Sammut SJ, Pollington J	anon	Pfam-B_16084 (release 10.0)	Family	This family represents the protein product of the gene pha-1 which coordinates with lin-35 Rb during animal development. The protein is expressed during embryonic development and functions in the cytoplasm. PHA-1 acts in a parallel pathway with UBC-18 to regulate the activity of a common cellular target [1].	21.50	21.50	23.00	22.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.75	0.70	-5.75	8	118	2009-01-15 18:05:59	2003-07-18 15:08:16	6	3	5	0	117	123	0	344.80	28	74.95	CHANGED	VN+oFNhullcpIRp-acpVll+s....hcp..Dhtpc.........pp.spulhlNsp+lphpphp...pahRFLKpss+I+Vp+lhlc-h.....cphshps-l..HpsIhcsLlsssh..pplcEFhGhssIC.pGChtCtcIutsCpsYGPlQhsh...hhttc+HF-tLpls-hhlthlh..........lps.p.s.......thh-phIssploCD+LplhLsshh..pthsh......lsR-llDhlltpWpVKoVcl........tah............hptphshlphppchhs..hpTpPtupa.sL-pV-Islphu...spshtp.h+ppt....Sl.sF-NhIuNV+RIFPTpclplcLPppl..h.hs.ssh-cFlpsllcMs.+-sp....RNS+Ish+La....sppl..ph...........lsshhpcspsh+...........................p.l..h..........p.ph.pupsaph	................................................lNKshN..hLphlRppapphplch..............................ps..hlaI..Nh++lp.ppl..........................sa...F...FLspsstV+V....cclhhcpl.......................t..htpph....HchIhppLIG.sst..................pplpplIGh-...-l.C..tG....C..pC....plApc..Ch.-.YGPlphps..hpphp..sppa+cLploDtLhcpIAp..........lppspppp......shppLsphIhs..sISCDpLslhl..s.E....p..h............pps..........................hPREVl-hll+KWsVKSlcl............phhpp............tWhphs...hFTplc...h.sc.......h........ppppsch....+hp+VpVsls.S..hsp.sh.hp....ht........ts.apNhIsNlRRhF.scplohp.hs+hh.....h...slcchhpsllphhph-pp....ppLpl.shpha................................................................................................hp....h....h........................................................................................................	0	15	16	117
+6371	PF06543	Lac_bphage_repr		Lactococcus bacteriophage repressor	Vella Briffa B	anon	Pfam-B_16088 (release 10.0)	Family	This family represents the C-terminus of Lactococcus bacteriophage repressor proteins.	20.10	20.10	20.10	20.40	19.50	20.00	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.43	0.72	-4.43	4	31	2009-09-11 15:56:52	2003-07-18 15:42:07	7	3	23	0	5	22	0	49.90	55	35.06	CHANGED	cpppcslDLADlV........DDsKVDWDcWVSFDG+PLoDEVKcAMKthhGKcLpD	.....ppEslDLAcLV........DDsK.VDWD+WVSFDG+PLTD-VKpAhKhlhGK+LpD...	0	2	2	4
+6372	PF06544	DUF1115		Protein of unknown function (DUF1115)	Vella Briffa B, Sammut SJ	anon	Pfam-B_16104 (release 10.0)	Family	This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.	27.60	27.60	27.80	27.80	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.61	0.71	-4.46	37	568	2009-01-15 18:05:59	2003-07-18 15:54:08	7	14	302	0	389	542	2	126.60	26	28.30	CHANGED	hhsa+I....ts.p+Rh+lhpsA+phpLoGhsl.hs..psullsVEGspcshccah+h.l++lpW......tt.tchptppppsp.h................................p...hhhps..tp+pF.pta.p.t..............s.s.sphhchLpc.......ps.stphaphsh	..............................................hsa+l...h.t.s.s..p+RhKlppsAppLtLTGhsl.h..........t......c......ss............lllVEG..spcu...hccat+Lhl+RlpW...................pp.ptppp-s.tp.t...........................................................h.hhhc..u..t.....p..pR..tF...ppa..p.p.................p.s.sthpchLpc........ps.hpchaphh....................................................	0	135	200	296
+6373	PF06545	DUF1116		Protein of unknown function (DUF1116)	Vella Briffa B	anon	Pfam-B_16143 (release 10.0)	Family	This family contains hypothetical bacterial proteins of unknown function.	20.10	20.10	21.00	20.50	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.28	0.70	-5.25	21	940	2009-01-15 18:05:59	2003-07-18 16:05:16	6	5	543	4	68	423	39	213.70	60	44.22	CHANGED	lphtPCHcasAVGPMAGlhSsSMPlalVcs.pstGscuassLNEGlG.KlLRaGAhsp-VlpRLcWhccsLuPsLppAlt.....tpGsl-LpslhApALpMGDEsHsRNtAuosLLl+pLsPhll....p.sshspppht-VhpFlussDtFFLNLsMAAsKshh-AAp...slssSolVTsMuRNGscFGIRluGh.GscWFTuPAssspGhhFsGaut-DAssDlGDSA	...........lsF.PCHchsAVGPMuGlTSASM.MhlVcN....tT.GNcAYsNhsEGlG.KVlRFGA.spsVlsRLpWMRDVLuPhLpsAlt.....httsIDLpsMhAQulpMGDEhHpRNhAuosLLhpALsPtIh.........p..hsasp.....pphtEVh-FlusoD.FFLslhMAhCKAAMDAut...tIctuolVTsMsRNGspFGlRVSGL.G.spWFTuPsp.p.s.pGhhF.sG.as.EDussDhGDSA...........................	1	30	46	57
+6374	PF06546	Vert_HS_TF		Vertebrate heat shock transcription factor	Vella Briffa B	anon	Pfam-B_16244 (release 10.0)	Family	This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress [1]. This C-terminal region is found with the N-terminal Pfam:PF00447, and may contain a three-stranded coiled-coil trimerisation domain and a CE2 regulatory region, the latter of which is  involved in sustained heat shock response [1].	20.50	20.50	21.00	20.70	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-12.22	0.70	-4.99	6	211	2009-01-15 18:05:59	2003-07-18 17:17:15	6	3	60	0	80	199	0	220.80	29	52.29	CHANGED	uaSuoshhuPDssspsGPIISDlT......ELspuSPssosssSl-sp...sS.PllhIKE.....EPsSPupSPc.sE..P.t.phssGssh.ssT.hSPsshls..SILpEs-Ps............................s.phCLSVACLDK..................................sELpDHLDoIDssL-sLQsMLSu+uFSlDoosLhDLFSsSlsh..sDhslPDhcsSLASIpchLSstc.....stspEupsupscosKQLlpYTA.PLhhh............suus-s.uSsDhPh.h.ELt-uShhop..t..E.PT.uLLs.p.pPhsc-PshS	............................................................................................................................sthht.ct..hpss.II.DlT.........................E..h...s.P....ss....sh......-..p.............t..P.lh..lhE.....................E.sss.....pu....sp.pp...........s................sps....sp....s.h...s.sss.ls..S.Lppp.psss...s.........................................hs..slshL..s+...............................................................................................................sEL.DaLDuhDssL-shQshLsuctaolDss.hL.hDlFssuh........h..............sshtu.pp.hhps.........h..p...s...p..p......s....sppLlpYT.u.P.hhh....................s.s.....ss...s-hPh.h.EL......tss.h..p..............Po.uhL..............t..................................................................	0	6	11	38
+6375	PF06547	DUF1117		Protein of unknown function (DUF1117)	Vella Briffa B	anon	Pfam-B_16251 (release 10.0)	Family	This family represents the C-terminus of a number of hypothetical plant proteins.	25.00	25.00	33.40	33.20	21.60	19.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-11.02	0.71	-3.99	7	55	2009-01-15 18:05:59	2003-07-21 17:18:57	7	5	15	0	37	55	0	107.60	53	28.91	CHANGED	sVG.LTIWRLPGGGFAVGRF..uGGpRuGERpLPVVYTEM.DGGhNss...suPRRISW....uSR.....ssRSpER.tG.ltRhFRNhhuhFuphpsupSsSut.tStssp..p.....pspp..olhSpSsRRR	..sVG.LTIWRLPGGGFAVGRF..uGGtRsuERc..L..PVVYTEM.DGGFNsu.........uuPRR..I.SW.....ssp............su+upps...tGhltRhFRNhFusFGR..hpsss.S.s.Sup..t.ut...........................................................	0	3	22	31
+6376	PF06548	Kinesin-related		Kinesin-related	Vella Briffa B	anon	Pfam-B_16517 (release 10.0)	Family	This family represents a region within kinesin-related proteins from higher plants. Many family members also contain the Pfam:PF00225 domain. Kinesins are ATP-driven microtubule motor proteins that produce directed force [1]. Some family members are associated with the phragmoplast, a structure composed mainly of microtubules that executes cytokinesis in higher plants [2].	24.00	24.00	24.60	24.40	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.78	0.70	-5.94	10	95	2012-10-05 12:31:09	2003-07-22 10:00:52	6	7	24	0	51	91	0	320.50	36	43.48	CHANGED	uPT-SLAASLQRGLcII-.HppssAsRRSoVuhSFcphshpPs.tsssKlsuuVQo.Pc-ptspt...s.hLCssC+pptsssus.p-.ssh.p..h..hsss.............KuspKVlttAl+REppLEphCs-QAuKIpQL.............oullsQh+csp..c.pp......spt...............lL+pt.p.scsEslppphEsKclpEEhc.shpph.h-luE+EsLLcEIp-LKsQLp...hssotoosphpuSLLthohQlRp......sh..ttsscstpcsL-cER.+WTEuEScWISLTEELRl-LEusRphAEKhchELcpEK+CoEELcDALpRAMhGHARhlEQYsELQEKYs-LLp+HRplh-GIsDVKKAAAKAGhKG.sGoRFAsALAAELSALRlEREKERchLKcENKuL+hQLRDTAEAVQAAGELLVRLREAEEAsolAcERsstsEpEs-KLKKQlEKLK+KH-pElsThKQ...hLAES+LP	.........................................................................t..p.pLAuSlp+Glplh-.apts..h.ppu.hthsht.ht.p.........phssth.................hh...sp......t................................................................pt...h.t.s..cph.hct.C.cQsscI.pL..............................................................................pth.pc......tph...hs-+E.L.tEItpL+tpLp.............p.t.t...........h....p.p.............................ps.....t......h.E.EScWlsLs--LRh-l-sp+.hhtc.p.ELp.EKhsstElp-AhphAh.GHuRhlEpYs-LpEha.tLhthHphh.tGlt-VKptAu+A.uh+G.tt.tFhtuhusElosl+hp..+E.......ppNctLp.QLpDTAEAVpAAGELLVRL+EAEcAhs.upcphh.hppEspchhpph-cLK++ac.Eh.shpphL.-uph...............	0	7	26	35
+6377	PF06549	DUF1118		Protein of unknown function (DUF1118)	Moxon SJ	anon	Pfam-B_17963 (release 10.0)	Family	This family consists of several hypothetical plant proteins of unknown function.	22.50	22.50	22.60	22.90	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.54	0.71	-3.95	5	63	2009-01-15 18:05:59	2003-07-22 11:33:40	7	3	28	0	33	64	1	105.80	48	53.76	CHANGED	+LEK+KVLSsVEKoGLLS+AEcLGlTLSSlE+LGLLSKAEDLGLLSLlENsAuhSPuALASlALPLLlAAIAAVVLVPDDSssLVAlQAVlAuALVlGGouLFVGSVVLuGLQESD	..................plEchKlLopsEKAGLLStAEchGloLSslE+.LGLLSKAE-L..GlLShs..ps.u....oPus..Lho..lA.LsLLlAussslhlVP-Dssh.VslQsV.lAhshslGuuuhasuSsllusLQpu........	0	13	24	29
+6378	PF06550	DUF1119		Protein of unknown function (DUF1119)	Moxon SJ	anon	Pfam-B_17985 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.18	0.70	-5.27	5	64	2012-10-02 13:41:03	2003-07-22 11:36:36	6	2	60	0	45	154	100	273.30	36	93.22	CHANGED	suLFVlVQlLALLLusPhpsuEhQ..AaEsPTpslNSIa.YIVhlLlFThFVLIsIK+cKKWlIptlIYlslVu.VlaYVFhlLLoll.slAGhlNllSlllAIuLshLLYtYPEWYVIDlAGshlAsGlSALaGISFGVlPAVVLLIlLAVYDAISVYKTKHMIoLAcGVMDL+LPILFVIPcspsYSFls-oF-su--tEA..........tssaFIGLGDAVMPSILVVSAAlFl-o..l.uGlpYssLsAMuGTLlGhlVLhhhVhRGRPpAGLPaLNoGAIAGFLIGsLhuGl	....................................................................h..hhlhlQlhALhLs.....shtt.sshp..shEsPpsssNslh.Ylshl.Llh.TuhhLhhh+..hshphllphll....hhshhh..hhhYVa..tsll.s...hh..............h...h..................hhuhlhu.l...u.ls.sh.L...h....h.YP.E....WYV.ID.hsGllhu..A.G.su.ulFGISh.u.ll.P....s.llLLslLAVYDAISVYtT....cH........MlsLAcG.....Vh.-h....+lPllhVlPpphsY..Sahc.....t.....s.....htt.tt.pt.t.t...........................................................tsAaFlGlGDslhPolLVs........SAsh..F.....h..s.s.....s......l.............h...l...s....l..P..u...L.s.AhlG...ol.hGh.h.l.L.h.h.h.V.h.+.G+spAGLPhLNuGAIhGallGslhs...........................................................................	0	10	37	42
+6379	PF06551	DUF1120		Protein of unknown function (DUF1120)	Moxon SJ	anon	Pfam-B_17948 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  --amino -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.42	0.71	-3.78	7	319	2012-10-02 17:35:21	2003-07-22 11:42:21	7	1	164	0	52	239	31	98.50	32	43.39	CHANGED	LKVTGplssuACTPpLoGGGsVDaGphpsssLpss....chspLGhKsholsIoCsusstlAhsupDsRtsT.......t..tsshsh....shs..Gtt..s.ssttFGLGpossGtKIGAau	.......LKVpGpls.suuCTsp..l.s.s.GG.llDaGpls...supL.ps.T......p.s.s.pL...u.p.+.s.hol.oIsC.s.u..sTh...luaossDNRssS.......................................GlG....................................................................................	1	7	17	40
+6380	PF06552	TOM20_plant		Plant specific mitochondrial import receptor subunit TOM20	Moxon SJ	anon	Pfam-B_17991 (release 10.0)	Family	This family consists of several plant specific mitochondrial import receptor subunit TOM20 (translocase of outer membrane 20 kDa subunit) proteins. Most mitochondrial proteins are encoded by the nuclear genome, and are synthesised in the cytosol. TOM20 is a general import receptor that binds to mitochondrial pre-sequences in the early step of protein import into the mitochondria [1].  	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.21	0.71	-4.70	6	100	2012-10-11 20:01:00	2003-07-22 11:48:36	7	11	46	1	51	128	5	147.30	31	55.26	CHANGED	FDRLlhFEHsRKsAEsTYtpNPLDADNLTRWGGALLELSQFQsls-uKpMIpDAISKLEEALlIsPtKH-AlWClGNAaTSauFLosD.sEA+.pF-hAopaFQ.AhsppPsNplY+KSLEhssKAPcLHhthhppt.hp..hGst........ssussSsKohKpKKoS-hKYDlhGWVILAsGVVAWluFAK	..............................................hF-.spctuptthtpsP.D..s-s...LspWGtALlELup...h....pps.....-u....h.p.hlp-AlsKhccALtlsPppa-AlaslGsA........houhu.......h.hp....s-....p....tpA....pphFcc....AsphFppAhs.cP...ssphYppuLph......................................................................................................................................................	0	16	36	43
+6381	PF06553	BNIP3		BNIP3	Moxon SJ	anon	Pfam-B_18014 (release 10.0)	Family	This family consists of several mammalian specific BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation [1].	26.00	26.00	55.60	29.30	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.48	0.71	-4.93	14	210	2009-01-15 18:05:59	2003-07-22 11:56:35	7	2	85	6	101	187	0	181.60	45	95.99	CHANGED	MSssttss................EsuLpsSWVELphsssssspss...............................st.p.lPssSp..sG-hE+lLL-AQ+Epup.SSR....sSSps-SP.ps.oP..pssth.hssp..spps...ppp-cshct..t......KssDWlhDWSSRPENlPPK-FhFcH........PK+.........osshShRpotshKc.ulFSs-hLhlhlPollLSHlLulGlGlaIGKRLsh.spsoh	..................................................ttLpuSWVELphssssss.ss.......................................................................................................s...t.p.lPuosu.hsGD.hEKILLDAQHESup.SS+.......sSS+CD..S..........P.ts.ps..pp..sst...hssc..psp+s..soQSEE-shEtc+-h-.........hpKsuDWlhDWSSR..P..ENlPP.K..EF.hF+H.....................P..KR.........osoLSMRpous..M...KKGGlFSuEFLKlFlPSLlLSHl.LA.lGLGlYIG+RLssso.s..h............................	0	17	28	61
+6382	PF06554	Olfactory_mark		Olfactory marker protein	Moxon SJ	anon	Pfam-B_18049 (release 10.0)	Family	This family consists of several olfactory marker proteins. Expression of the olfactory marker protein (OMP) is highly restricted to mature olfactory receptor neurons in virtually all vertebrate species from fish to man.	25.00	25.00	76.60	76.50	19.10	17.70	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.74	0.71	-4.68	4	40	2009-01-15 18:05:59	2003-07-22 12:01:40	7	1	27	7	9	43	0	138.60	65	94.58	CHANGED	hELsFs.DhQLTchMRLRVQSLQQ+GpK+QDGE+LL+ssEpVYRLDF.ScQcLpFspWNVsLpuPG+lsITGTSQhWTPDLTpLMTRQLLEPsulFWRps...-s-slcC.EADAQEFGERIAELAKlRKVMYFLIsFt-GssPtslcCSlsFpp	........h-hshs.D.pLTc.MRLRVpSLpQRGpKRQDGE+LLpPsEuVYRLDF.ppQ.+.LpFpRWsVsLcpPGKVTITGTSQhWTPDLTNLMTRQLL-PsAlFWRc-...-s-shchpEADA.EFGERluELAKlRKVMYFLhsFt-GscPsslcsSlsFp...	0	1	4	8
+6384	PF06556	ASFV_p27		IAP-like protein p27 C-terminus	Moxon SJ	anon	Pfam-B_18169 (release 10.0)	Family	This family represents the C-terminal region of the African swine fever virus IAP-like protein p27. This family is found in conjunction with Pfam:PF00653. It has been suggested that the family may be a host range gene involved in aspects of infection in the arthropod host, ticks of the genus Ornithodoros [1].	25.00	25.00	26.80	26.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.89	0.71	-4.25	2	20	2009-01-15 18:05:59	2003-07-22 12:41:11	6	2	16	0	0	9	0	129.00	90	57.50	CHANGED	ATLGIIGLKKMIDSYNDYasNEV.VKHKNRVYTHKRLEDMGFSKsFMpFILANAFhPPYRKYIHKIILN-RYFTFKFsAaLLSFHKVNLDNQhTYCMTCGIE.IpKDENFCNACKsLNYKHYKhLNFSVKL	...........ATLGIIGLKKMIDSYNDYYNNEVFVKHKNRVYTH.KRLEDMGFSKPFMRFILANAFIPPYRKYIHKIILNERYFTFKFAAHLLSFHKVNLDNQTTYCMTCGIEPIKKDENFCNACKTLNYKHYKTLNFSVKL...........	0	0	0	0
+6385	PF06557	DUF1122		Protein of unknown function (DUF1122)	Moxon SJ	anon	Pfam-B_18183 (release 10.0)	Family	This family consists of several hypothetical archaeal and bacterial proteins of unknown function.	25.00	25.00	33.90	65.80	24.60	23.60	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.16	0.71	-5.10	6	37	2009-01-15 18:05:59	2003-07-22 12:43:05	6	1	37	3	20	29	0	155.50	43	86.76	CHANGED	lG.pl...pLcu.clhQs+hpE.psFplhl...ss+..pLspshhFpGRt.YYhPWIEI.shsP.LR........ptslEscLacFlhshLssuG+lFVpYhcD+EThptL.+GhsPAsTcLGFpLLKtGFTWFKsWYaPEGh.EGG.KlQApKPLoc-ccpRpLppLhcElK.phltph.sStlt	....hhhht.......s.sl+ps+hpE.hshpLhl....ssc..plspsphFpGRs.YYsPWlEl.sh.Phhp.........spslEcphacllhpaLsPGu+LFVpYlcDpETtptL.+GhsPs-T.LGhpLLpsGFTWFKDWYFPEGG.EGs.KLQusKPlst..th+pLp.lht-lc..p.h.........t..........	0	7	10	16
+6386	PF06558	SecM		Secretion monitor precursor protein (SecM)	Moxon SJ	anon	Pfam-B_18197 (release 10.0)	Family	This family consists of several bacterial Secretion monitor precursor (SecM) proteins. SecM is known to regulate SecA expression. The eubacterial protein secretion machinery consists of a number of soluble and membrane associated components. One critical element is SecA ATPase, which acts as a molecular motor to promote protein secretion at translocation sites that consist of SecYE, the SecA receptor, and SecG and SecDFyajC proteins, which regulate SecA membrane cycling [1].	25.00	25.00	28.50	28.50	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.94	0.71	-4.53	10	529	2009-01-15 18:05:59	2003-07-22 12:49:01	7	1	522	0	41	182	1	145.30	72	84.14	CHANGED	MVAASLGLPsLssuupsss..Pupuoops+psSspssFssLALLcsssRRP..oFoVDYWHQHAIRTVIRHLSFAh.APQslPsupEs.......sPLQsQHLALLDTLsALLTQEupPPsllR...phspssFhP...usaplulWIuQlQGIRAGPptLS	..............MVAASLGLPALS.NAAEsNA...PAKATopNHpsS.........AKVNFuQLA.....LLEAssRRP.......Na.SVDYWHQHAIRTVIRHLSFAM...AP..QTLP..VAEEo........hPLQ.AQHLAL...LDTLSALLTQEG..TPsptsh....Rl-aAaFsP..QAp.FSoPlW.ISQAQGIRAGPQRL....	0	1	9	24
+6387	PF06559	DCD		2'-deoxycytidine 5'-triphosphate deaminase (DCD)	Moxon SJ	anon	Pfam-B_18211 (release 10.0)	Family	This family consists of several bacterial 2'-deoxycytidine 5'-triphosphate deaminase proteins (EC:3.5.4.13).	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.94	0.70	-6.07	17	532	2012-10-03 01:18:03	2003-07-22 12:52:18	6	3	521	4	109	933	819	232.00	47	87.95	CHANGED	hstsh.....sGILP-csItshhusGtIssshshsssQIQPASLDLRLGspAaRVRASFLPGsuRoVs-RL.--hthHclDLocGAVLETGCVYlVPLhEuLuLPsslsAsANPKSSTGRLDlFTRlITDputtFDplsAGYsGPLYsEISPRTFslLVRsGsRLsQlRFRpGpshLs-s-LttlHtppsLssu..tsh.ssGlulSVDLtuptss.LVGYRAK+HoGVlDlD+hGsacst-FWEPlhspsup...LILDPGtFYILsS+EAVplPPshAAEMsPasshVGEFRVHYAGFFDPGFGpssAGGsGSRuVLEVRuHEsPFlLEHGQsVGRLVYE+MsstPssLYGtsluSNYQuQGLKLSKHFtu	..............................................................................p...........LsDpDIc.Ahl-.pG..t.luh...s.s.t.s...s...-pIpsAolDlRLGs..+...s..a.R.s....+....Au....F......L..s.....G.P.p.c.....p.V.us.t.L..-+..l....h..........c...E......I...s....L..s...-..G....t..s..L..c.s......Gplh.lss.......hLESlsLP.u-lsuhhsu+SShuRLsLhs+VhAc..............................................................................................................................................................................................................................................................................................................................h...............................................	0	27	64	85
+6388	PF06560	GPI		Glucose-6-phosphate isomerase (GPI)	Moxon SJ	anon	Pfam-B_18250 (release 10.0)	Family	This family consists of several bacterial and archaeal glucose-6-phosphate isomerase (GPI) proteins (EC:5.3.1.9).	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.26	0.71	-5.26	6	215	2012-10-10 13:59:34	2003-07-22 12:56:42	6	3	164	25	77	297	86	161.90	26	66.57	CHANGED	VR+hpDhtulhhDEpsapth.E.hsc-ssY-Vp-htps-c-u-......LpaslThl.PGplGcEahhTpGHaHsp.....ss+PElY.slcGpushLLQp.P-s..........-ltVltscttsslhVPPhauHpolNsG-ssLlhsshhsuDsupcY-sIs+tuGhphhllcsGt..h.ppssss.c	.......................................................h.tt..thh.s.............t.sphhYp.l.h.thht.ppctp......L.aslThl.hPGplGp.Eh...hhTpG.HaHsh.........hsps....ElY.slpGcuhhl.L.Qc...-s............csh..s..lpsptGshlhl..PPsauHp....oINs.G.cp.....s.Ls..hushhsps..huhc..Ytslpptthht.hh..h.h.ppGt.............................................	0	22	51	67
+6391	PF06563	DUF1125		Protein of unknown function (DUF1125)	Moxon SJ	anon	Pfam-B_18065 (release 10.0)	Family	This family consists of several short Lactococcus lactis and bacteriophage proteins. The function of this family is unknown.	25.00	25.00	28.70	28.30	24.10	23.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.84	0.72	-4.27	2	19	2009-01-15 18:05:59	2003-07-22 13:02:46	6	1	16	0	3	7	0	54.60	66	81.59	CHANGED	MTV.lKsphsphIlpFchGsDIEsFSsuFLa+KIKhhcIKNt.-L.hhLEDTKND	..MTV.lKsphsphIlpFchGsDIEsFSsuFLa+KIKhhcIKNt.-L.hhLEDTKND	0	1	1	1
+6392	PF06564	YhjQ		YhjQ protein	Moxon SJ	anon	Pfam-B_18260 (release 10.0)	Family	This family consists of several bacterial YhjQ proteins. The function of this family is unknown. However, the family does contain a P-loop sequence motif suggesting a nucleotide binding function.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.51	0.70	-5.01	9	638	2012-10-05 12:31:09	2003-07-22 13:44:36	7	3	570	0	80	5749	2006	228.30	57	95.90	CHANGED	MslLuLQGlRGGlGTTSlsAALuWALQhLGEsVLVIDhSPDNLLRlpFNlDacppcGWARA.LDGpsWp-uuhRYsstLDLLPFGpLsssEhEs.pt.hpsshutaspslptLpttupYcWlLlDLPt...GhSslTRphlphsDpsLsllpsDANCHlRLHQQsLPsusclLlNchphuSQLQpDLaQLWL.QoppcLLPl.llHRDEAhuEsLAuKQPLGEYRsDSLAAEElhTLANWCLlpht......puss	.................................................................................MAlLGLQGV.RGGVGTT..T...lTA.A.L..A....W.u.L..Q.h....L..G.......E....N.V..LV..l..D.....A.......s...P.....D.....N......L.........L.........R....L........S......F........N.......V........D.......F.......s..........H.....p.......p........G........W.......A........R..........u.....h......L.........D.......G......p.......D...........W.......R..........D.........A.....G......L.........R.........Y.......T......S...........Q....................L.....D.....L....L........P...............F.....G........Q..........L....o.......h......p.....E......p.........E.......N..............s........Qp...........W....Q.......p......c.......L.......u.......-........I.........s...o....u....L.........Q.....p..L........K......A.............S.......G...R......Y..p..W..I..Ll..D.L.Pt........s.uS...l.T...+.Q.L..........l..S.L.C...DH.oL..A....l...l.......p............V............D..............A.............N............C.............H............I..........R.........L............H...........Q............Q..........A.......L...........P..........s..........G.........A.........H..........I........L.....I........N.....s...........h.......R.......I....G.........S....Q....l...........Q.D...D......l.....Y....Q....l....W..L....Q...S.......Q.....R....R.........L......L.....P.....h......l.......I.H......RDE.A.M.A.ECLA.u.K.Q.Pl..GEYRSD.uL..AAEElLTLANWCLLp.uG..hKo.......................................................................................................................................................................................................	0	5	16	51
+6393	PF06565	DUF1126		Repeat of unknown function (DUF1126)	Moxon SJ	anon	Pfam-B_18695 (release 10.0)	Family	This family consists of several eukaryote specific repeats of around 35 residues in length. The function of this family is unknown.	21.20	21.20	21.90	21.20	18.70	19.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.06	0.72	-4.47	100	901	2009-01-15 18:05:59	2003-07-22 13:48:32	7	10	125	2	576	907	19	33.10	40	13.93	CHANGED	llpYaLsDDTlplhE.shscNS.Gh.stGpaLcRp+	.......hlpYaLpDDTlplhE.sh..hcNS..Gh.stGph.l+Rp+....	0	273	335	466
+6394	PF06566	Chon_Sulph_att		Chondroitin sulphate attachment domain	Vella Briffa B	anon	Pfam-B_16515 (release 10.0)	Domain	This family represents the chondroitin sulphate attachment domain of vertebrate neural transmembrane proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis [1]. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylation [2].	25.00	25.00	71.60	70.70	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.84	0.70	-4.74	3	37	2009-09-11 06:23:37	2003-07-22 13:53:27	6	4	24	0	17	45	0	225.00	74	43.01	CHANGED	lPsPEAGSAl..........EAEssV+SVPAWEsRANDTREcAGsPAAG-DET....ShpEsGSEpAsVGPGVGPEEuLEASAAVTuTAWLEA-SPG..............LGGVTAEAG.SGDoQuLPATLPTPDEALGoSosSsAlPEATEA........SsP......PSPuPGDKPSLlPELPKESPlEVWLNLGGSTPDPp.............uPEPTaPhQGTLEPpPASDIIDIDYFEGLDGEGRGsDhG+FPGSPGTSE+HPDsGGETPSWSLLDLYDDFTPFDESDFYPTTSFY....DDLEE	............................................-suSAh..........EA-t.h+us.shEs+ANsTp-tsu.PsAG---s....ohpt.G..up....u...........hGPEEs.LpASAAVTuTAWLEs-oPG..............LGGsT.sEsG.SGDsQuLPATL.sPcEsLspSshPPAhPEATEA........SsP......PSPTPG.....DK.SP.....usELP....KESPLEVWLNLGGSTPDPp.............GPEPTaPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSEpHPD..T-GETPSWSLLDLYDDFTPFDESDFYPTTSFY....DDL-E........	0	1	1	3
+6395	PF06567	Neural_ProG_Cyt		Neural chondroitin sulphate proteoglycan cytoplasmic domain	Vella Briffa B	anon	Pfam-B_16515 (release 10.0)	Family	This family represents the C-terminal cytoplasmic domain of vertebrate neural chondroitin sulphate proteoglycans that contain EGF modules. Evidence has been accumulated to support the idea that neural proteoglycans are involved in various cellular events including mitogenesis, differentiation, axonal outgrowth and synaptogenesis [1]. This domain contains a number of potential sites of phosphorylation by protein kinase C [2].	29.40	29.40	36.20	37.20	21.80	29.30	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.78	0.71	-3.98	2	68	2009-01-15 18:05:59	2003-07-22 13:57:31	6	5	29	0	34	83	0	77.70	59	21.61	CHANGED	LYLLKTENoKLR+T.KaRTPSELHNDNFSLSTIAEGSHPN...........................DDPuAPHKlQDPLKstLK-EEshsI..ShuPc.EGuKG-.sshGVsCLpNNLs	...............LalLKTENsKL.R+psKaRs.sSEhHNDNFSLSTIAEGSHPN.................................pD-ssh...................p.php-shK.......s...K--tshsl..ShsPc.Est+..................................................	0	1	4	10
+6396	PF06568	DUF1127		Domain of unknown function (DUF1127)	Moxon SJ	anon	Pfam-B_18606 (release 10.0)	Domain	This family is found in several hypothetical bacterial proteins. In some cases it represents it represents the C-terminal region whereas in others it represents the whole sequence.	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-7.85	0.72	-4.54	170	1368	2009-01-15 18:05:59	2003-07-22 13:57:49	6	3	640	0	307	914	205	40.10	32	58.60	CHANGED	ts..lhpthtpa....pptR....pop.ppLspLo-+pLpDlGl.sR..u-lpp	..........................h.tlhpshpp.W...........pct+..............pst.p....tLpphoDcpLcDIGl.sR...p-l............	0	40	125	194
+6397	PF06569	DUF1128		Protein of unknown function (DUF1128)	Moxon SJ	anon	Pfam-B_18651 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	20.60	20.60	21.40	21.40	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.27	0.72	-4.25	15	417	2009-01-15 18:05:59	2003-07-22 14:07:06	6	1	417	0	40	132	0	68.40	50	95.73	CHANGED	hSppopEslphMI-pI+cKLplVNhullcs-cFssspa-DLc-IY-hVM+K-oFSPSEMQAIs-ELGsLRK	........ht..spE....MVtuI+EKLphVNtGllcs-cacsss.E-LpDIY-aV.p.REphSPSEhpAIA-cLGpLR+....	1	11	23	32
+6398	PF06570	DUF1129		Protein of unknown function (DUF1129)	Moxon SJ	anon	Pfam-B_18737 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	29.10	29.10	29.20	29.10	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.24	0.70	-5.01	23	957	2012-10-01 22:34:14	2003-07-22 14:10:58	6	1	920	0	81	444	0	203.50	30	88.26	CHANGED	cLTKKNp-alaphp+pL.hpsuho---hpthLp-hlPcll-sQKpGhTARpLaG.sPophspplhps.pptscssp............hhhh.................LDsuLhhlulhslhhGlhshFuptstssh.....GllTLllsuhsuGhshhhhh+alh......hc+scRsshhKthhhlshshllWhslashsuh.LPsslNPsLsshlhllIGulAhulRaal++KYsIpuu	.......................Lop+Nppalh.h..ppph..htssh..o-p-.hctllpcllspllpsQp+GhoApsLaG.sPsphAcuhtpptt.h.pcpsc...........s.hh.hh..............................hDssLh...l...h.....u.l...h...u....llp.u.l....h....s..aF.sp...t.supsh........Gl..l...ol.lh.hu....l.l.uG.hsh.h.h..h.ahalhth.......shspSp+..s..sha..+tl.hlll.h..shh.ha.h.l.lFh.s...suh...L.s..ss.lN..s.h..L..s.s..hshh.Ilu...slhhsl.+.aal+++hsl.s.......................................................................................................	0	15	37	60
+6400	PF06572	DUF1131		Protein of unknown function (DUF1131)	Moxon SJ	anon	Pfam-B_18811 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.60	20.60	23.00	21.10	18.20	17.00	hmmbuild  --amino -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.93	0.71	-4.78	8	552	2009-09-14 12:02:21	2003-07-22 14:28:26	7	2	547	2	43	181	4	169.20	76	88.35	CHANGED	SuhsWSuhuPaNWF...GS.ShEVT-QGVGsITAuTPLsEsAIscALsGDYRLRSGMcTssGplVpaFpAhKscpltlVIsG-.cGsVsRIDVhDscIsTssGVKIGTPFSDLYSKAFGsCppusuD.-ssuVECtAspSpHlSYlFoGcWuGPEsLMPsDDsLKsWcVSKIIW+p	................SSVNWSAANPWNWF...G..S..STcVSEQGVGcLTASTPLpEpAIADALDGDYRLRSG.MKTsNGN.VVRF.FEsM..KG.D..N..VAM.V.ING-..QGT.lSRIDVLDSDIPussGVKIGTP.FSDLYSK.A.F.G.NCQKAcG.D.Ds.puVECKAEGSQHISY.FS.G.EWSGPEGLMPSDDTLKN.W.KVSKIIWRR...................	0	4	12	26
+6401	PF06573	Churchill		Churchill protein	Moxon SJ, Bateman A	anon	Pfam-B_19061 (release 10.0)	Family	This family consists of several eukaryotic Churchill proteins. This protein contains a novel zinc binding region that mediates FGF signaling during neural development (unpublished obs Sheng G and Stern C).	25.00	25.00	36.20	35.90	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.71	0.71	-4.07	7	78	2009-01-15 18:05:59	2003-07-22 14:37:27	6	3	49	1	36	61	1	99.20	68	61.12	CHANGED	MCssCVpcEYPDRGshCLEsGSaLhNFVGCupCspRDFVLIsN+.ssp--DsEEIlTY-HhCKNCcHVIAcHEYTFoVsDDaQEYTMLCLLCG+AEDolSlLPDDPRQ.sPLF	....MCGsCVcKEYPsRGNTCLENGSFLLNFsGCAsCsKRDFhLIoNK.Slc.EED..GEEIVTYD.HlCKNCHHVIARHEYTFSlhDEaQEYsMhChLCGp.u-DohSlhP-DPRp.t.L........................	0	10	12	19
+6402	PF06574	FAD_syn	Flavokinase; 	FAD synthetase	Moxon SJ, Mistry J, Eddy S	anon	Pfam-B_18632 (release 10.0)	Family	This family corresponds to the N terminal domain of the bifunctional enzyme riboflavin kinase / FAD synthetase. These enzymes have both ATP:riboflavin 5'-phospho transferase and ATP:FMN-adenylyltransferase activity [1].  They catalyse the 5'-phosphorylation of riboflavin to FMN and the adenylylation of FMN to FAD [1].  This domain is thought to have the flavin mononucleotide (FMN) adenylyltransferase activity [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.74	0.71	-4.60	62	4652	2012-10-02 18:00:56	2003-07-22 15:00:27	7	15	4320	17	995	3311	2386	148.80	31	49.28	CHANGED	h.tt.pssllslGsFDGVHhGHppllspshphA....pppsl.ssVhTF-P+Ppphhp............pptshc.LoshccKhchlpphG.lDhlhhlsFsppFuplouccFlpphLlppLps+tlllGhDFpFG+pppGshphLpphupths.apVphlssh..phsstclSSTt	....................................pssslsl.GsFDGVHhGHptllpphpc.hA.....................c..p..p..s..l............s.s..VhTFcPpPtp..hht.......................ppsshp....Lsshc-Khchl....tp..h..G......lD......hlhh.l..pFs...ppF...u...p...los.ppFlpphLh.tpL.p.s.+.hlllG.DFpFGp...p.+.p..Gs.hphLpph..ut.....t.....h....s..Fp.lph...ss.ph.....p...p.s.....+.l.SST........................................................................................................	0	342	672	856
+6403	PF06575	DUF1132		Protein of unknown function (DUF1132)	Moxon SJ	anon	Pfam-B_19091 (release 10.0)	Family	This family consists of several hypothetical proteins from Neisseria meningitidis. The function of this family is unknown.	25.00	25.00	83.70	83.50	22.20	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.39	0.72	-3.70	4	69	2009-01-15 18:05:59	2003-07-22 15:24:27	7	1	39	0	3	29	0	94.10	64	89.32	CHANGED	hALYKYQPSSKYFGQSMAlIAppEF.EFs+ssKpasllEsFSaFLN+RlsHNIWKIYFSDESshaI+.....cS.csG+pl+cF.asEhsDs.ssFsslFs	LALYKYQPSSKYFGQSMAlIAQpEF.EFs+.sKp..sVI-CFSaFhN+RlpHsIWhI.FSDpSphhI+......cS.csG+placF.asEhsDs.ssFsslF.........	0	3	3	3
+6404	PF06576	DUF1133		Protein of unknown function (DUF1133)	Moxon SJ	anon	Pfam-B_19184 (release 10.0)	Family	This family consists of a number of hypothetical proteins from Escherichia coli O157:H7 and Salmonella typhi. The function of this family is unknown.	21.70	21.70	21.70	21.70	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.19	0.71	-5.09	4	284	2012-10-04 14:01:12	2003-07-22 15:29:15	6	3	180	0	2	194	0	164.10	76	95.54	CHANGED	MI.PopsGKSGEhlRLpTLESlWIQGKLRMWGRWSYIGGGpuGNMFNpLLuStKlTKTAlNEALRRMKKuGIcKPELEAFhREhlsuKpKShLAaCoDsEuLpIDtVIupVLsc..asGLhullhpRYchR.hSKRpMAEpLpspHP-WshhTCcRRI-sWLulAEphLYsPMsDuFG	.......................MIYPp.TGKS.GEHLRLpTLEuVWIQGKLRMWGRW....SYIG.GG....KoG.NMFNQLLsSKKLT.K...TAINEALRRMKKuGl-KPELEAFLR-MIsGKQK.SW..LuHCT.D.uEALhIDRV....IuEV.LAc..aPGLlslL+Q............RYcGRGMoK.............RKMAELL.N-..............s.H.P.............EW............shp............TCE+RIttWLtVAEahLYhPMh.uF....................................	0	0	0	1
+6405	PF06577	DUF1134		Protein of unknown function (DUF1134)	Moxon SJ	anon	Pfam-B_19217 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	27.80	27.80	28.00	27.80	27.30	27.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.96	0.71	-4.74	26	198	2009-01-15 18:05:59	2003-07-22 15:31:14	7	1	193	0	77	155	20	160.70	59	75.36	CHANGED	ssoYsp-EllsuucsFFGpsotGLApllEcsFpchGpPNGYIlGcEuSGAhlsGLRYGEGsLapKssGc.++lYWQGPSlGaDhGGsuuRshhLVYNLssspsLYpRFsGlsGSAYlVuGhGhshLppssllLlPIRoGVGhRLGlNlGYLKaTpp.TWsPF	.................ssoYot-ElVcuGHcFFGssStGLAsslE+AFppaG.h.PNGYILGEEGSGAFluGLpY.GEGTLYTKNA.G.c....++laWQGPSLGaDaGGpGoRsMhLVYNLsslpsLYpRauGVsGSAYlluGlGhssL+pssIVLVPIRo.GlGARLGlNlGYLKhotpPTWNPF............	0	20	46	58
+6406	PF06578	YscK		YOP proteins translocation protein K (YscK)	Moxon SJ	anon	Pfam-B_19248 (release 10.0)	Family	This family consists of several YscK proteins. The function of this protein is unknown but it belongs to an operon involved in the secretion of Yop proteins across bacterial membranes.	20.60	20.60	20.60	20.90	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.59	0.71	-4.93	9	84	2009-09-10 17:11:24	2003-07-22 15:37:43	7	1	78	\N	13	49	2	201.50	43	94.20	CHANGED	sulTsaQhRFCPAuYlccualPsphhhlLs.LPpWRspPslNthLL--huL....-suachPssLGuLALhPputLppLLthLGulLHGpAlRpslLupslpplhsllGp-GtRhLlpQh-lLIGsWPsGWQ+PLPpplc-shhEpsuLpF...WL.....uAsp-hs.sWtpRLsLRLs.ssssssW.lupppRsLApsLChKIAKQVsPQChHLLK	........................................hlTsaQLRFCPAtYlH.spLPuhh......h.p..lLshLPpWRc...s..u..tLNuhLL-cau.L....Dssac..pPpsL..GuLsLhPQutLE..tLLshLGhlLHG.pAlRpslLusslp.p.LhsllGp-shR.ll.Qt-LLIG.sW...PstW.QRsLPsph-pth....h.psGLsF...WL.....AAhpstspsWs+RLsL..RLshsss.stsW.l....sEppRsLApsLChKlsKQVhPpC.HLhK...............................................................................	1	3	5	6
+6407	PF06579	Ly-6_related		Caenorhabditis elegans ly-6-related protein	Moxon SJ	anon	Pfam-B_19267 (release 10.0)	Family	This family consists of several Caenorhabditis elegans specific ly-6-related HOT and ODR proteins. These proteins are involved in the olfactory system. Odr-2 mutants are known to be defective in the ability to chemotax to odorants that are recognised by the two AWC olfactory neurons. Odr-2 encodes a membrane-associated protein related to the Ly-6 superfamily of GPI-linked signaling proteins [1].	21.00	21.00	22.20	21.30	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.94	0.71	-3.93	4	68	2009-01-15 18:05:59	2003-07-22 15:46:10	7	1	9	0	59	59	0	113.00	30	62.49	CHANGED	CMS.hYpshapa..hp+hYpcPtsFospCcDsph-so.h.os.C..pohCVTlhps.cVhuG.hht+tYhRGChsslhh+GaNpo..+Tluhhpp.p.C+shotopLF.sstpc-..t.uclplCSChGshCNhS	........................CMS..Ypsha.....lpphYhhP+sFTcpCpc.pht.tu.hsss.C..pohCVolhEs.sl..............h.ut....h........htptaIRGChsclhhpGhNps..tThth.hpppp.Cpphptp..pLa...th.tp....pplplCoChsshCN.................	2	21	30	59
+6408	PF06580	His_kinase		Histidine kinase	Vella Briffa B	anon	Pfam-B_794 (release 10.0)	Family	This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence [1]. Members of this family often contain Pfam:PF02518 and/or Pfam:PF00672.	21.30	21.30	21.60	22.70	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.71	0.72	-4.06	82	7029	2009-01-15 18:05:59	2003-07-22 15:49:28	8	139	2576	0	1632	5611	368	82.50	32	15.92	CHANGED	clchLpuQlsPHFLaNoLssIpthsphs..sppstphlhpLuchlR..hsl...psppphloLp-ElphlcsYltlpph..Rascclph..ph	...................clcsLpuQINPHFLFNoLssI..p..t..hh..ph..s...s......cc..spphlhpLSphhR..............hsL......pps............p...........ch.....lsLpcElphlcsYltlp.ph..Ras.c.+lphp....................	0	783	1309	1483
+6409	PF06581	p31comet	DUF1135;	Mad1 and Cdc20-bound-Mad2 binding	Moxon SJ	anon	Pfam-B_19462 (release 10.0)	Family	This family is involved in the cell-cycle surveillance mechanism called the spindle checkpoint. This mechanism monitors the proper bipolar attachment of sister chromatids to spindle microtubules and ensures the fidelity of chromosome segregation during mitosis. A key player in mitosis is Mad2, and Mad2 exhibits an unusual two-state behaviour. A Mad1-Mad2 core complex recruits cytosolic Mad2 to kinetochores through Mad2 dimerisation and converts Mad2 to a conformer amenable to Cdc20 binding. p31comet inactivates the checkpoint by binding to Mad1- or Cdc20-bound Mad2 in such a way as to stop Mad2 activation and to promote the dissociation of the Mad2-Cdc20 complex [1].	24.10	24.10	24.20	25.50	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.64	0.70	-5.52	3	64	2009-12-03 16:30:54	2003-07-22 16:00:29	7	2	48	2	39	60	0	238.90	56	86.91	CHANGED	SsAAAPsL-WYEKPEETHAsEV-.LETVhPPAQEPSNsuEPFCPRD.LVPVVFPGPVSQEsCCQFTCELLKHILYQRpQLPLPYEQLKHFYRK.VPQAEDss+KKsWhATEARNRKCQQALAELESVLSHLcDFFARTLVP+VLILLGGNALSPKEFYELDLSRLAPFGVDQGLNTAACLRRLFRAIFLADPFSELQTPPLMGTIVMVQGHRDCGEDWFQPKLNYRVPSRGHKLTVTLSCGRPSVPAMASEDYIWFQAPVTLKGFHE	................................................Lchh-cst-spsspl-.L-p...sspcs.ps.E.hpPcD.hVPVVFPGPVSQEGCCpFTCELLKHIhYQRQQLPLPYEQLKaFYRK...oP.....QA..E-hh+KK..spsssEso....sRKCQQsLuELESVL...SHL.E.shFAR.TL.VPRVLILLGGsALSPKEFYELDL..S.pLuPhS...h...-pSL.oTuAC........LR+LFRAlFhADsFSEL.QuPPLMGT...lVMsQ.GHRDCGEDWFRPKLNYRVPoRGHKLTVTL..S.....C....G...c.Pu.....l...............s......h.......A..h..EDYIWFQAPVTLKGF+E..............................	0	7	9	20
+6410	PF06582	DUF1136		Repeat of unknown function (DUF1136)	Moxon SJ	anon	Pfam-B_19544 (release 10.0)	Repeat	This family consists of several eukaryote specific repeats of unknown function. This repeat seems to always be found with Pfam:PF00047.	20.30	20.30	20.70	20.30	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-7.48	0.72	-4.17	78	617	2009-01-15 18:05:59	2003-07-22 16:05:55	7	56	46	0	370	869	0	29.10	36	5.14	CHANGED	lhh-oQcPp.....uL..c+IppLEsspp...+...pps	....llh-oQHPp.....uL...c+IppLEsspt...t+....-...........	0	135	170	323
+6411	PF06583	Neogenin_C	Neogenin_C-term; 	Neogenin C-terminus	Vella Briffa B	anon	Pfam-B_16188 (release 10.0)	Family	This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites [1]. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of Pfam:PF00047 and Pfam:PF00041) and is closely related to the DCC tumour suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues [2].	25.00	25.00	29.10	27.50	20.30	21.60	hmmbuild  --amino -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.40	0.70	-4.86	10	213	2009-01-15 18:05:59	2003-07-22 16:44:25	7	31	76	1	91	194	0	242.30	41	21.17	CHANGED	KDLKPPDLWIHHEchELKslDKSscssPsh.TDTPI.posQDlsPlssohpopsp..s+psSYpGtEoE-uhS.......SLAuRRuhRsK..MMhPhDoQPsps.VlSAhPl.oLDsspa....G.LsSPspuY..HtphShhshshssho...shst..pspusposssTPpsshlPsusupst......................................................................................................................s.ssEEssupSlPTA+lRP......oHPLKSFAVPulPsss..u.hpPtlP.oPlhsQ....................................suso.hstppVKTASlGphG+sRSP.hP...VoVPoAP-lhEsu.+hhEDo-s.......................................sYEsDELScEMAsLEGLMKDLNAITuu	...............................................................................................................................................................................................KDl+PPDLWIHHEchEhKsh-Kus.ssss.h....p-oPl..ps.s.QDl.ssss.pu.pop.p..p+ps...S.....apGt-sE-s..S........oLuuRRuhRsK..h......MhPhDuQs.s....ps...h......t.sh.sh..-pspa.....................Ptpta..h...s.......s....hho.....ht.............sp.ph.ss.pss..hhssspsp....................................................................................................................................stppssupolsouphRP......sHPL+SFusP...hlPssh...s..tstl...oPhhsp........................................tu.s.h.hp.VKTASlG.hhG...+.sRsP.hs....VsVPsAP-l..E..ps...+hh-Dsts.........................................saps--LopEMApLEGLMKpLNAITss.......................	0	20	28	56
+6412	PF06584	DIRP		DIRP	Studholme DJ, Guo, JH	anon	Pfam-B_2017 (release 9.0)	Family	DIRP (Domain in Rb-related Pathway) is postulated to be involved in the Rb-related pathway, which is encoded by multiple eukaryotic genomes and is present in proteins including lin-9 of Caenorhabditis elegans, aly of fruit fly and mustard weed. Studies of lin-9  and  aly of fruit fly proteins containing DIRP suggest that this domain might be involved in development. Aly, lin-9, act in parallel to, or downstream of, activation of MAPK by the RTK-Ras signalling pathway.	21.90	21.90	22.20	37.30	20.70	19.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.40	0.72	-4.19	14	225	2009-01-15 18:05:59	2003-07-22 17:01:08	8	4	120	0	127	239	1	104.50	44	15.67	CHANGED	FYSslD+shFp.cs-FtphL.cphs.h+sp+LTRsEWphIRpphGKPRRhSttFlpEERpcLpphRcplRph...pthp.pt...phshhcsL.....Pp-..lsh.PLslGp+VhAhh.t	..............FYSsID+....PhFp..c...s-Ft.hLtEp................h...P.L+.op...+LTRsEWshIRR.M....GK.....P.RR.hSsuFhcEERpcLcppRpplRtL.......Qpp+hss..........su.hcsL..................Pcc..lPh.PLslGs+VoApL+.s.................................	0	44	67	99
+6413	PF06585	JHBP		Haemolymph juvenile hormone binding protein (JHBP)	Moxon SJ	anon	Pfam-B_19686 (release 10.0)	Family	This family consists of several insect-specific haemolymph juvenile hormone binding proteins (JHBP). Juvenile hormone regulates embryogenesis, maintains the status quo of larval development and stimulates reproductive maturation in the adult insect. JH is transported from the sites of its synthesis to target tissues by a haemolymph carrier called juvenile hormone-binding protein (JHBP). JHBP protects the JH molecules from hydrolysis by non-specific esterases present in the insect haemolymph [1]. The crystal structure of the JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a much curved antiparallel beta-sheet. The folding pattern for this structure closely resembles that found in some tandem-repeat mammalian lipid-binding and bactericidal permeability-increasing proteins, with a similar organisation of the major cavity and a disulfide bond linking the long helix and the beta-sheet. It would appear that JHBP forms two cavities, only one of which, the one near the N- and C-termini, binds the hormone; binding induces a conformational change, of unknown significance [1]. This family now includes DUF233, Pfam:PF03027.	27.40	27.40	27.70	27.50	26.40	27.30	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.35	0.70	-5.56	92	924	2009-01-15 18:05:59	2003-07-23 12:02:26	6	11	65	12	627	1020	0	226.30	17	89.17	CHANGED	Mphhhhhh.........hlhhhhhshtttt....................................st.hptCphs.........hspCltpshpp.hh.phss.G..lPch...slssl-Plplsplplpt.....tshshphshpshplhGhss....hplpch....phchp.phphphphthP.plphpG.cYphpGp.llh.......lslpGpGphphshpshphphphphphht..t...ssp..pahpl..pphchphc.l.sphphphpNLFss.sptLspshsphlNpshptlhpphps...slpcshsphhhshhsclhpph.............Phcclh	...............................................................................hhhhh.h....................................................s..ht...Ctht...............hspClhpshpt.hh..htp.G........lPph..slssl-P.hh...l........s.p...hphp......ttsshthphsh.pshplh.Gh.ss............hplpph.............phshp..ph...p.....h..p..h..phphP..p.lph.p...u.p...Y.phpGp..lhh............lslp.upGp.hphsh.ps.hphphp.hphphhp...t.....................ts..pahpl.....pph.phphp..l.tph.p..hph..p.sl.hs.t...sp...l.s.p..hhsphlN....pshptl....h....pphps.....ltpthsp.h.hhs.hhs.phhpphshpph........................................................................	0	184	250	520
+6414	PF06586	TraK		TraK protein	Moxon SJ	anon	Pfam-B_19687 (release 10.0)	Family	This family consists of several TraK proteins from Escherichia coli, Salmonella typhi and Salmonella typhimurium. TraK is known to be essential for pilus assembly but its exact role in this process is unknown [1].	26.00	26.00	26.00	26.10	24.50	25.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.35	0.70	-5.23	26	481	2009-01-15 18:05:59	2003-07-23 12:08:45	6	7	366	0	71	334	15	227.20	29	80.82	CHANGED	M...........hhsllhusslhussh..........tstuspslshss............suphslslSssshNRlslssD..+Is.........slsssputh.....p.pc....psssGslhlp.......shsstshThalpTccGhs..aSltlsPcsssu.colhls..............shstsppcs...tsaEssssY.pptlsplspuhhs....Gphss.Gaphtslspps.......................h......hstsLphp.ttsasGsphpuhhac..lcNtsspslslpEpcFhp.....sust....Alhlspt..pLtPGppsplal	.............................................................................h.hhs.........h.....................huspslshss.......................................GsphslslSsss.NhhslP.s-..clh..........................................slss..s.sth.......t.pp.........psss.G.sllls..........ossppP.hohhlp..sc..p..G..h..s...hSlphlP.+.c.ssu.+slpLs...........................ssht.sssccA......ssW..E.s.u.....s.PY...pshlhsl.pultt.......GclPs.Gat.h.ss.pcs..........................ht.........ssssl..shh..tsthas..Gsc.hphhhat...VcNts.pslplpEpsFap.....sush......AVh.hpp..tpLhsGtchclYV..................................................................	0	19	37	55
+6415	PF06587	DUF1137		Protein of unknown function (DUF1137)	Moxon SJ	anon	Pfam-B_20097 (release 10.0)	Family	This family consists of several hypothetical proteins specific to Chlamydia species. The function of this family is unknown.	20.10	20.10	21.60	179.40	17.00	19.40	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.87	0.71	-4.57	3	37	2009-01-15 18:05:59	2003-07-23 12:11:45	6	1	36	0	4	15	4	159.60	70	98.01	CHANGED	MTKFLFaGLFCSLuLLllACsThVAIIKVDsICDVSCMNK.HFpcAPPFLKIKKLGV+KQIsSPE+QFFaC+IDKSCMELHFSsoSYuCKElLS+LSGHIpTQshEKtMpFRGNGGLLNYQDsSLsVYDCRFpVDPl..asoPDAE-Eh....AsGGMKTLSLSLL	MTKFLFHGIWClVVLlLCAClTALAVVKMGcFTNPTLVHQDssTPAPPFLKIKKLGVRKRIISPEKQhFYCTIDKSCMELHFSNTSLHCRELLSHLTGsLQTETsERAMFFRGTGGLLNYKDYSLSVYNCCFSINs....ssP-uscEh....AEGGMKVLSLSLL.	0	1	1	3
+6416	PF06588	Muskelin_N		Muskelin N-terminus	Moxon SJ	anon	Pfam-B_20299 (release 10.0)	Family	This family represents the N-terminal region of muskelin and is found in conjunction with several Pfam:PF01344 repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1 [1].	19.60	19.60	19.70	19.70	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.37	0.71	-4.63	4	139	2012-10-03 19:46:52	2003-07-23 12:22:06	6	16	96	0	85	129	2	172.00	54	26.47	CHANGED	.pchLsYpIapaSSYSusYlPpNILlDsPpDtsSRWSspT......Ns..QYllLKLc+sAlVpsITFGKacKsHVCNlKKF+VaGGh-pcpMh.LLpuGLKNDsshETFsLphKp.p...p.hsspYlKIVPLhuWGssFNaSIWYVEL+GlDDs.hlpsph+.hshhhEtcul+hCL+aFRppGah-hapsLpcpoplplEHs	..................................phLsatlaphS.SaSss.YlP.c.......NILVDpPsDQoSR.WSopo...........................N...PP.QaLlLKLc+PAIVpsITFGKYEKoHVCNlKKFKVaGGh..s.-..ENM.............sELL.puGLKND..stETFsLKHcl-..............p.....phFPsRaIKI...VPLh.....SWGP.SFNFSIWYVELpGI-DPc.lVp....sslphYspaREpEAI.RL....CLKHFRQ.psYh-AFcuLQ+pTpltLEHP.........................................	2	40	44	63
+6417	PF06589	CRA		Circumsporozoite-related antigen (CRA)	Moxon SJ	anon	Pfam-B_19386 (release 10.0)	Family	This family consists of several circumsporozoite-related antigen (CRA) or exported protein-1 (EXP1) sequences found specifically in Plasmodium species. The function of this family is unknown.	22.20	22.20	22.90	25.00	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.81	0.71	-4.91	3	21	2009-01-15 18:05:59	2003-07-23 12:28:07	6	1	8	0	7	21	1	134.10	69	98.50	CHANGED	MKILSllFL.LFslILsN-ALG-N...sNGchGSGNspKKpsKptSGEPLIDVHDLISDMVRKEEELVclTK+KSsYKLAToVLAoALGVVSAVLLGGAGLVhYNTEKGRHPFpIGuSKsGDuA.scssS.sssEPoP...uP....p-ssPsAophcDssLsSGsEu	....MKILSVFFLALFF.IIFNKESLAEK......TNKGTGSGVSSKK.....KNKKGSGEPLIDV....HD.....LISDMIKKEEELVEVNKRKSKYKLATSVLAGLLGVVSTVLLGGVGLVLYNTEKGRHPFKIGSSDPAtst.....................................................	0	2	3	6
+6418	PF06590	PerB		PerB protein	Moxon SJ	anon	Pfam-B_19494 (release 10.0)	Family	This family consists of several PerB or BfpV proteins found specifically in Escherichia coli. PerB is thought to play a role in regulating the expression of BfpA [1].	25.00	25.00	127.20	127.10	21.90	19.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.89	0.71	-3.85	2	14	2009-09-11 14:43:35	2003-07-23 12:35:24	6	1	4	0	0	12	0	102.70	94	100.00	CHANGED	MKNNLREEKEVVhDGChNVLSLPStWKAITPKKNNsTSEIIVFFIPPKASYHIILKYspTKHCELFFSDHITGEQDlIYSQsAFFSHVINHIIALVDVLNKKSYASNVIKFLITMEGGGDILSESKRAP	MKNNLREEKEVVFDGCMNVLSLPSGWKAITPKKNNsTSEIIVLFIPPKASYHIILKYNKTKHCELFFS................................................................	0	0	0	0
+6419	PF06591	Phage_T4_Ndd		T4-like phage nuclear disruption protein (Ndd)	Moxon SJ	anon	Pfam-B_19553 (release 10.0)	Family	This family consists of several nuclear disruption (Ndd) proteins from T4-like phages. Early in a bacteriophage T4 infection, the phage ndd gene causes the rapid destruction of the structure of the Escherichia coli nucleoid.  The targets of Ndd action may be the chromosomal sequences that determine the structure of the nucleoid [1].	25.00	25.00	26.10	25.30	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.00	0.71	-4.64	2	31	2009-01-15 18:05:59	2003-07-23 13:29:45	6	1	28	0	0	26	0	148.50	58	98.82	CHANGED	.KYhThpDL.ssGupVlusl+sGEa..Go..pK-hhS+.GFYFhV.up.DhR......VuARFaVGpQRSKQGhsAlLSHIRQtRSQLARThusNNl.YsVhalsAppMKPLTTGaGKGQLALAFTRNHpSEYQTLpEMNRhLADNF+FlLQuY	..............................pYMTlpDLpsAGATsIGslK........sGEa.hhGsP.pKD.....I.LocPGFYFlV.uchsu.....ssVuARFYVG.NQRSKQGFsuVLSHIRpRRSQLARTIA..sNs..lsY.sVaYlPASKMKPLTTGFG..KGQLALAFTRNHpS-YQTLEEMNRMLADNFKFlLQAY....	0	0	0	0
+6420	PF06592	DUF1138		Protein of unknown function (DUF1138)	Moxon SJ	anon	Pfam-B_19518 (release 10.0)	Family	This family consists of several hypothetical short plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.	25.00	25.00	25.50	25.50	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.38	0.72	-3.97	5	64	2009-01-15 18:05:59	2003-07-23 13:30:54	8	1	30	0	35	50	0	72.60	62	80.72	CHANGED	uKYIIGuLsGSFAlAYVCD+aIADcKlFG..............GTTP+TVosKEWGpATDEKFQAWPRTAGPPVVMNPISRQNFI.VK	...........sKYIluuLlGSFAlAYlCDhhlu-KKlFG..............GTTP+TVosKEWapsTDc.KFQ.AWPRT.AGP..PVVMNPISRQNFI.VK........	0	4	18	27
+6421	PF06593	RBDV_coat		Raspberry bushy dwarf virus coat protein	Moxon SJ	anon	Pfam-B_19630 (release 10.0)	Family	This family consists of several Raspberry bushy dwarf virus coat proteins.	25.00	25.00	25.20	405.60	23.80	17.10	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.60	0.70	-5.17	2	18	2009-01-15 18:05:59	2003-07-23 13:33:28	6	1	3	0	0	17	0	272.80	94	100.00	CHANGED	MuKKAVPP.VKAQYELYNRKLNRAIKVSGsQKKLDASFVGFSEuSNPtTGKPHADMSMSAKVpRVNTWLKNFDREYW-NQFASKPlPRPAKQVLKGSSSKSQQRDEGEVVFTRKDSQKSVRTVSYWVCTPEKSMKPLKYKEDENVVEVTFNDLsAQKAGDKLVSILLEINVVGGAVDDKGRVAVLEKDAAVTVDYLLGSPYEAINLVSGLNKINFRSMTDVVDSIPSLLNERKVCVFQNDDSSSFYIRKWANFLQEVSAVLPVGTGKSSTIVLT	MSKKAVPPIVKAQYELYNRKLNRAIKVSGsQKKLDASFVGFSESSNPETGKPHADMSMSAKVKRVNTWLKNFDREYWDNQFASKPlPRPAKQVLKGSSSK......SQQRDEGEVVFTRKDSQKSVRTVSYWVCTPEKSMKPLKYKEDENVVEVTFNDLsAQKAGDKLVSILLEINVVGGAVDDKGRVAVLEKDAAVTVDYLLGSPYEAINLVSGLNKINFRSMTDVVDSIPSLLNERKVCVFQNDDSSSFYIRKWANFLQEVSAVLPVGTGKSSTIVLT.	0	0	0	0
+6422	PF06594	HCBP_related	HCBP_repeat; 	Haemolysin-type calcium binding protein related domain	Moxon SJ	anon	Pfam-B_20041 (release 10.0)	Domain	This family consists of a number of bacteria specific domains which are found in haemolysin-type calcium binding proteins. This family is found in conjunction with Pfam:PF00353 and is often found in multiple copies.	21.40	21.40	21.60	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.93	0.72	-4.32	116	953	2009-01-15 18:05:59	2003-07-23 13:37:28	6	179	153	0	316	1046	112	43.60	28	9.86	CHANGED	D..Lllplsso......sDplplpshasss........shtl-plpFADGTsWstssl	......................DLllplt..ss........sDplplpsaFpss...............shpl-plpF.uD.G..oshshsp..............	0	121	261	274
+6423	PF06595	BDV_P24		Borna disease virus P24 protein	Moxon SJ	anon	Pfam-B_20092 (release 10.0)	Family	This family consists of several Borna disease virus (BDV) P24 proteins. The function of this family is unknown.	25.00	25.00	36.00	36.00	19.70	19.50	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.41	0.71	-4.55	3	112	2009-01-15 18:05:59	2003-07-23 13:42:16	6	1	11	0	0	86	0	143.90	73	99.99	CHANGED	MATRPuSLV-SLEDEEDPQTLRRERSGSP.RPRK.VPRNALTQPVDQLL+DLRKNPSMISDPDQR.TGREQLSNDELIKKLVTEL...AENSMIEAEEVRGTLGDISARIEAGFESLSALQVETIQTAQRCDHSDSIRILGENIKILDRSMKTMMETMKLMMEKVDLLYASTAVGTS.APMLPSHPAPPRIYPpLPuuQssD...phDIIP	..................................................LLcpl+KNPSMISD.DQR.TGREQLSNDELIKpLVTEL...AENSMIEAEplRGoLuDIuARlEuGFESLSuLQVETIQssQ+sDaSDSI+lLGENIKILDRSMKTMMETMKLMMEKlDLLYuosAlGss.APMhPSHPuPs+lYPpL...........................	0	0	0	0
+6424	PF06596	PsbX		Photosystem II reaction centre X protein (PsbX)	Moxon SJ	anon	Pfam-B_20149 (release 10.0)	Family	This family consists of several photosystem II reaction centre X protein (PsbX) sequences from both prokaryotes and eukaryotes.	25.00	25.00	31.00	31.00	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.75	0.72	-4.28	22	156	2009-01-15 18:05:59	2003-07-23 13:45:41	6	2	118	15	61	149	93	38.30	48	46.53	CHANGED	MTPSLu.NFl.SLlhGuhlVVlPlssALlhlSQpD+lpRs	....hTPSLp.NFLhSlluGu.lVllsIssAllhVSphD.VcRp.	0	17	43	56
+6425	PF06597	Clostridium_P47		Clostridium P-47 protein	Moxon SJ	anon	Pfam-B_20156 (release 10.0)	Family	This family consists of several P-47 proteins from various Clostridium species as well as two related sequences from Pseudomonas putida. The function of this family is unknown.	19.30	19.30	19.30	19.30	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	456	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.56	0.70	-5.97	12	113	2010-01-04 16:41:40	2003-07-23 13:50:17	6	2	34	0	16	91	2	408.90	26	80.93	CHANGED	ThGWDhVauhshphVNct.hphppts.spF..S..hucttplpGsFssWpIhsG......Gsup.lplthPltp...Gsht.hpssshslsGhssslplcLsah.....P.....t.s..otsssphpl.s..hpss.tpps.............t.....tss..........h.pshhptllhphl......pNhcphsalFuolNls..h.pt.phpWhpPs.hpYAYts.sss.psuhLGlLuhsssRsh...u.pLppplDsshlsssupsGhLIScplFlcsllLPsLspsF.ssustssFclhspssp.......hpltsstplsltslpsuuhhYpPhlspFslp.lpsshlphphps+s-ls.Glshhhpshshpshphhhpsssppplsap.spsP...phopcsahsshslIsthlhuslsthlhts................Itutltstls...................s.hs.hlphsss.lpWss...shhslosssLssshphpG	.............................................................ThGWDhVhusshcslNct..hch...ts.......tcF.....sh..pspthph....p..GpFssWplhsG......GsGpplRlKhPIKs.....uhhp......h.....ps....sshshs..s.s..s....h..lplc.Lsah.....................s....p..p.s.....s....ts....s...phph.h.h.psppsp.......pcs.....................t...............p.hhptlhtphh........pNhpphshIFusl.ls...t...chpWhpPsthpYuas......s..ss...........s...........s......ssuhLulLshlss+sh...o.p.ppslDss.hl....s.p....so..p.s.....uhlIScphFlcphlLPs.L.spth.pthssssFplhsp.sp.......htlpNsp....pl...sht..slp...s...s...s...h.hh...P...hl...s..p..hplp..lps..shlhlphp.......st.s..cls...Ghpthhphhp..p...hph.htsssppphsac...hpps....phsppst.s.hphl..th.lhuslsthhhts....................ht..s.h.h.l...............................s..h......l.as....p..php.h.h.s.....................................................................................................................	0	1	7	12
+6426	PF06598	Chlorovi_GP_rpt		Chlorovirus glycoprotein repeat	Moxon SJ	anon	Pfam-B_19883 (release 10.0)	Repeat	This family consists of s number of repeats found in Chlorovirus glycoproteins. The function of this family is unknown.	21.00	21.00	24.40	22.00	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.64	0.72	-4.10	36	321	2009-01-15 18:05:59	2003-07-23 13:53:39	6	11	7	0	0	321	19	34.10	45	25.53	CHANGED	aFlGNGohLoulsss....lsustshDIhGNVsus.uNV	.aFhGNGotLTGlsss....lsushshD...I.h.GNVhus.uNV....	0	0	0	0
+6427	PF06599	DUF1139		Protein of unknown function (DUF1139)	Moxon SJ	anon	Pfam-B_20355 (release 10.0)	Family	This family consists of several hypothetical Fijivirus proteins of unknown function.	25.00	25.00	26.10	25.90	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.05	0.70	-5.25	3	19	2009-01-15 18:05:59	2003-07-23 13:56:02	6	1	7	0	1	19	0	275.40	53	99.24	CHANGED	M-psps-EYuSY.pStslEFDPpcPpINLVNsDFDEsDYsDL-VlLLosDasclpslAl.RIKNAP-YTsEIFEclDslssFs-LFDoEIlEcWsDhDsFhDLRls-sEs-FEhlSShLT+HhQollsspPslLWoolspLAKpSVIQus-D.FsllNYWchMNRRWEhIs-ELRlsFlFRAFcLKusQhtpVS+ILSsSLhFPGLNLIGK+ShIPMhoNaSIPEYLDHWFPTDDYcSDNYLpFIRFsElssscWKKIVVQaYLRpVFS..+VRTKl.......LIAssDVDaWYoLFMRTLIF+SMl+TKsLIKslLNa	...................................MsYshuscYuSh.+SssLEFDPpDPElNLlNQ-FDEsDYpDL-VN.LS-DLSslNLlAT.RIKNuP-YTsEIF-ShDsP.PFApLl-pEIu-EWCDhsNFhDLRlV-sEs-FEFVSSHITcHLLIlLNSNPNlLWTussLLsKlSLlQcssN.F-llNYWcAMsRRW-lIsD-LKhGFVFRAFsLKuNQFElloKLLSDSLhasGIslIGK.SMlPMlTlHSIs-YlDHWF.T-sapSDNFhSFI+htpITVPKWKKlVVQFYLRQlFS..RsRTpV.......LhApsDlDaWYslFM+TLlFKSMh+TKphlKplLN........	0	0	0	1
+6428	PF06600	DUF1140		Protein of unknown function (DUF1140)	Moxon SJ	anon	Pfam-B_20379 (release 10.0)	Family	This family consists of several short, hypothetical phage and bacterial proteins. The function of this family is unknown.	25.00	25.00	25.30	74.20	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.29	0.72	-3.91	3	56	2009-01-15 18:05:59	2003-07-23 13:57:53	6	1	51	0	5	32	0	100.70	57	95.67	CHANGED	MTsEDIVpsYpclILKcIFKEIpp.hKoKERA-ls+pKlAEoGhuVRTSRHWKAsuNlEFYI+EhpctLcQLtELDRpa+WScKLHQDRapFVoKYscVLEEY..RptN	......-llppYpshlLKhIhhcIpp.hKpKE+A-lst.chAEsGs..sVRTStaWKusuNhEFYhpEh.cthsthtElDR.hpWSc+LHQ-phKFVpKY.clhEcY..RpuN.....	0	2	4	4
+6429	PF06601	Orthopox_F6		Orthopoxvirus F6 protein	Moxon SJ	anon	Pfam-B_20433 (release 10.0)	Family	This family consists of several Orthopoxvirus F6L proteins the function of which are unknown.	21.30	21.30	21.30	38.70	21.00	19.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.53	0.72	-4.05	2	33	2009-01-15 18:05:59	2003-07-23 14:00:38	7	2	20	0	0	17	0	71.80	88	96.03	CHANGED	MSKILTFVKNKIIDLIpNDQIKYSRVIhIEESDSLLsVDEVaANHGFDCVEMIDENI.NENlEQYKT-SFhp	MSKILTFVKNKIIDLI.....NND.QIKYSRVIMIEESDSLLPVDEVHANHGFDCVEMIDENI.NENlEQYKT-SFhp......	0	0	0	0
+6430	PF06602	Myotub-related		Myotubularin-like phosphatase domain	Vella Briffa B, Bateman A	anon	Pfam-B_795 (release 10.0)	Domain	This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate [1]. Mutations in gene encoding myotubularin-related proteins have been associated with disease [2].	21.40	21.40	21.40	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.10	0.70	-5.68	24	1877	2012-10-02 20:12:17	2003-07-23 14:09:10	9	82	275	6	1093	1689	23	293.90	29	40.75	CHANGED	pLaAFtapsttst.t.p......ua........................phhchhpEacRh..........................................................Gls..spt........WRloslNcsYplCsoYPttllVPpsloDp...tLtpsupFRuppRlPVloahH.cstAsIsRsSQP....LlGh..spRstc............DE+ll.psl..................................................htspspscchhIhD.........................sRsphsAhAN+ApGuGhEspstY..................pschhFhsI...tNIHshRpShp+l...................hcss.....hptss.spalosL-sotWLpHlpslLpuushlsptl...c.cpsSVLVHCSDGWDRTsQlsSLApLhLDPYYRTlcGFpsLlEKEWluFGH+FucRsGHh................................................................tspsspphSPlFlQFLDCVaQlhcQFPsuFEFsEtFLlplhcHhaSCpFGTFLsN.sE+ERtcp	...........................................................................................................................................................................................................................................................th...............................p..t-hp.R...................................................................shs.....................W..+l....o.th...Np...p.a....p..............l...........s.oYPth...........lhVPt..th...s....-p........l...t..s.uthh...............pttRhP....................s..ls.........a...................h......p....t..s.t.....s.sl..h.R.....s..u...p.............su......t.ps.p.............................................--ph.l....thh.................................................................................................................................................................................................p...hl...hD........................................................................................t+s....h.t.t..............t....h.h.u..c...............h.......................................................................................hp...h...ht.h...........sl...+.....hp....p....ohp.pl...................................................hphs......................s.......tp.ah.....p..tlc.........po..t....W.L..p.h.....lp........hLptuh.l..sp.hl...............p...tt...sVl.lp........p....p.-G.hD.h..T...s.p.l...su.LsplhL......D.P.a...a........RT....l..cGF.............s......L...l-+-WlshGH.FtpR..hs.ph...........................................................................................................................................................................................................................t.t..p.pp.uP.l.......F........h.FlD.sVaQ...............l..h.pQ.......aP.ttFE....Fsp.ha........L..hh.lh.ph...........hus.auoFLhs.sttpR...h...............................................................................................................	0	353	476	753
+6431	PF06603	UpxZ	DUF1141;	UpxZ family of transcription anti-terminator antagonists	Moxon SJ	anon	Pfam-B_19606 (release 10.0)	Family	The UpxZ family of proteins acts to inhibit transcription of heterologous capsular polysaccharide loci in Bacteroides species by interfering with the action of the UpxY family of transcription anti-terminators. As antagonists of polysaccharide locus-specific UpxY transcription anti-terminators, the UpxZ proteins exert a hierarchical level of regulation, insuring that only one of the multiple phase-variable capsular polysaccharide loci per cell characteristic of this genus is transcribed at a time.	21.20	21.20	22.40	21.80	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.29	0.72	-4.02	13	133	2009-01-15 18:05:59	2003-07-23 14:15:26	6	1	25	0	19	121	0	104.90	51	69.86	CHANGED	plpsLQpsAHELLYLGhDGuPIYoDcFspLNpEVhppsssLasp..+GsTsEEEAsLCLALLMGYNATlYs.pGDKEp+hQslL-RsasVL-pLPASLLKspLLThCYG	..............hpsLpphAH-LlYLGhDGuPIYoDchspLNpEVacpsssLYsp..+GsTsEEEAslCLALLMGYNAohYs.pG-KEp+lQplLcRsaslL-pLPASLLKspLLThCYG.......	0	5	11	19
+6433	PF06605	Prophage_tail	DUF1142;	Prophage endopeptidase tail	Vella Briffa B	anon	Pfam-B_16284 (release 10.0)	Family	This family is of prophage tail proteins that are probably acting as endopeptidases.	27.70	27.70	28.00	27.70	27.40	27.60	hmmbuild  -o /dev/null --hand HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.75	0.70	-5.51	23	808	2009-09-16 13:04:28	2003-07-23 14:19:08	6	22	565	1	80	610	5	344.80	18	55.62	CHANGED	hs.plNsptsloFolhpscpNtpsashlsp..cphlha.....sspcYhIpphstps.Gpsht.hplpApH.lh.-lpsphlhpph..........sGs.........................holcshhc..hshpsoG..aoYpltss.hsshphp...shGs.pstL-lhppllcpa.GsEapsss+plp.lh..cplG.ppsshhlRataNhsslshphDssslhTtI+GYGc......................................................................................................................................................................................................................................................................................................................tppsstsphh.....h.hcYpSP.A.ch..aGh......+husslpD-RhTstssLcpthKpplp..csPchSlslsh.phpp...hhth.pcstlGDhlhlls-s...lGlshclRlVuhpp.hshssph...clshush......ppshsclhsplspsh+thp	......................................................................................................................................h...t.Nttt.lshsh....st..p.........phl.p....t.hl.h.......ptp.p......Y..hI.h.hs.p...tu.pt....lplpApc..hh.c.hp.p.p.hh.....sph.................sss........................................................hohpphhp......h..s...p...tos.....h.p.a.p.hh..ss...hp.p.h.p.hp.........phsp..pstl..-hh......p......phlppa....s..t.-....h.........h......h.........s.........s.....p..........p....l.......t....hh..p.p.....h....u.pc......ss..h..h..lphthNh..pslp.hphsspplhTtI..h..sa...G.p...........................................................................................................................................................................................................................................................................................................................................................................h..s.s.t..p..st......s.tht............h.h...p.......a.p.s....s.s...ch....aGh.............................h.u............s..h...p.-.pc...h...p..s...t...c..s.......Lh....ch..s.cp...plp........sp....Pp..hoh...sls..hh.l.t...........hsh.pphphGDsVh.lhpcp....hG..hs.s..plRllchpp.....pshhst....h....pplslush.................pcshh.p.h.p.thtp......p.................................................................................................................................................................................................................	0	36	62	77
+6435	PF06607	Prokineticin		Prokineticin	Moxon SJ	anon	Pfam-B_19802 (release 10.0)	Family	This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock [1].	21.30	21.30	21.50	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.47	0.72	-3.89	7	187	2009-01-15 18:05:59	2003-07-23 14:30:20	6	5	59	2	84	172	0	94.80	39	70.82	CHANGED	M+.phhphslLL....Lll........ssucuAVITGAC-+DhQCGsGhCCAVSlWlRulRhCTPhGppG--CHPhSHK.....................VPa.GKRhHHTCPCLPsLsCs+hsss+Y+Ch	.................................................................hhh....hhh...........s.....hh.l....oGuC-.+DspC....Gs.G....h.CCA...h..S.hWh+.u..l..phCsPhGppG-pCH..Pho+K........................l..P..a.....s.......c..R.ha..ppCPChPsLhCpph.....................	0	26	29	41
+6436	PF06608	DUF1143		Protein of unknown function (DUF1143)	Moxon SJ	anon	Pfam-B_19953 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins (from mouse and human). The function of this family is unknown.	20.40	20.40	20.40	20.40	20.20	18.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.21	2	50	2009-01-15 18:05:59	2003-07-23 14:32:26	6	2	35	0	31	49	0	132.60	55	82.63	CHANGED	hAspC.hspphhLQRQNLsCaLpNPHhGSlI.ADGHGEVWTDWNsMSKFhQYGWRCTTNENuYSNRTLhGNWNQERYDL+NIVpPKPLPSQFGHhFETTYDssYspKhP.STHRFKREPHhFPGHQPELDPP+YKCTtKSTYMssYScs	.................................h.hahtNPph.GSllpAsGHGEVWTDaNshSKFhQYGWRCTTNEssY.SN+TLhGNWNQERYDl+slV.QPKPLP..SQ.FuHYFETTYD..oSY.N....s.K...hP.S..........T..H...RF......K....REPHhFPGHQPELDP..PpaKs..T..t.+SshM.sYs........................................................	0	10	13	17
+6437	PF06609	TRI12		Fungal trichothecene efflux pump (TRI12)	Moxon SJ	anon	Pfam-B_19969 (release 10.0)	Family	This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes [1].	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	599	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.97	0.70	-6.33	2	214	2012-10-03 03:33:39	2003-07-23 14:37:16	8	8	86	0	151	7876	315	457.40	22	86.41	CHANGED	MTssV.EcGlDLESQPDDRhRApALAToAsELP-GYYpSPRllASFAuFShNVsATYFVLQASASALPNILQDlGQSENpuLFSTLWThGQAVSILhMGRLTDRFGRRPFVIhTHIlGLVGAIVGCTAsKFNTLLAAMThLGVAAGPAGuSPLFlGELMSNKTKFLGLLhVShPslshs.huPYhGQRLuIQGsWRWIFYIYIIhSsIAVhLIllWYaPPSFtQLHGKKspKR-ELAKlDWIGIhLV.sGsSLFLLGVSWGGpPNsPWNSuKlIGLhoSGhGoLVlFALYEVaGKP.pPhlPPuLFKDTRGFVCILlISSIMGuMpLsLsIhYPQQVlNIFGSSLKNWpETAWMoATASFGThAGVhlLGslFHLlRHIRWQILVGAhWLTAFLGAMSSlNRDNKNuAIALShhoGFVVuWAQDITMLhVQFITTDEsLGVAFuVVAAuRPFhGSIFTAAFISlYoNpYP+EluoHLoSAhRGTshPQuSFsSLLEAApoGRh-AVpALPGMTspIuuVVSpAMADSYTASYANVYYFAMALGVIPIIASLCMRDhDpYLTDHVPHQlYDRKpAcKDVL-GsS-o.sSPhIhShs-hc.	......................................................................................................................................h...............................................................................................................................................................................................................................................................................................................h.....h.....s......h..........h..................h.....s...........u...h.........h..............h....h....G.p.......l..o..D..h..h.G.R.+............h..h....l...h..s....t....h...l..h.l..l..G...........I...l...s..s..s......A........p...s.........h..........s.....t....h...l..u...u.......s...h............h.......G...h........u....s......G.......h......t..........h....h..........h........h......h.......u.....-.....h...........h...........s................+......h......+...........h.........h.......s......h.....h........h......h.........h.....s...................l.....h..................................h.....u.....s......h.......h.........u.........p..........h.........h.....s.........h.....t.........s.........s..........W.....R..a........h......h.....h..h...h....h..........l.....h...s.......s......l...u.....h....l....h......h......h..............h..........a..........Y..............a............P..............P..........s.....................h...................p..........h............p..........s........p.......t..........h.......p.........p.............t................p.....................l.......t............c........l........D.....a........l........G...h..h...L......h..h..s...G.l.s....L..FL.l....G....l....................s......a..G..G..............t......................s......W..s.S...u.+.l..l..u...........l.l.....h....G..h.......s..h..L..l.s..F....s..l...a....E.......h....a.......s...t.................p....p.............P.....h......h.....P.......p...L...h.p.......p............R....s......h...s....h....h....l....l.....l......s....h...l.......G......h..........h...h..s....h.......h....h...a..P....p....t.h.....h...s...l..a..s.....p...s...............................h....s..h...h.......s...h.....s...........h....s.h......u....h.h..h.u..s....h....l..............h....h......l....h.....p.......h....h....t...c...h......+......h...........h...l.......h..u...s......h...h..h...s...s...h...h..G...s....h....u...s..h..p.....p..s........t...h...h....h....u.h........h...h.....s....s.........h..s...h...u.h....h...............s........h....h......s....p...h......h....s....s......t.....p.................l..u...h..s.......u..l..h....h.......s..........R.........h....h....G....u....l....h.h.s....h....a...........s..l.h........s.......t.h...............h...s....t.........l....s.............s...h...h................s...h.s...........t...........h............h...h..t......h.......h.............s....................h........l........s.u.h.s.......t.......h...t...hh.......u....h.t........uas.u...h.......s..ahh..s.hs.h.uhl..shh.sshhh.....s...t...............................................hh.............................................................................................................................................................................................................................................................	0	41	82	125
+6438	PF06610	DUF1144		Protein of unknown function (DUF1144)	Moxon SJ	anon	Pfam-B_20026 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	32.00	32.00	21.40	19.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.76	0.71	-4.43	14	617	2009-09-10 16:34:19	2003-07-23 14:39:04	8	1	613	0	40	182	3	138.80	78	95.31	CHANGED	Mh..pss.phRsAsADTFAMVVaCFlsGMhIElhlSGMoFEQSLuSRLLSIPVNIhIAWPYGhaRDahlRput+luss+.ah+sluDllAYVoFQSPVYAsILhsVGAshcQIlTAVoSNhVVShhMGlsYGYFLDhCRRhFRVs	....MF...SPQSRLR.HAVADTFAMVVYCSVVNMhIElFLSGMSFEQShhSRLVAIPVNILIAWPYGhYRDLhMRsARKlSPo.G.WhKNLADlLAYVTFQSPVYlA.ILLsVGADWHQIhAAVSSNIVVSMLMGAVYGYFLDYCRRLFKVS............	0	4	10	25
+6439	PF06611	DUF1145		Protein of unknown function (DUF1145)	Moxon SJ	anon	Pfam-B_20029 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	20.60	20.60	21.60	20.90	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.76	0.72	-4.34	33	759	2009-01-15 18:05:59	2003-07-23 14:41:03	7	1	737	0	88	256	38	60.30	54	67.24	CHANGED	hllsLGKhlhLhhWhhllhNLlhPFssslslhlslhhshhllMHslQlllhpush.tc..s	......MLINlGRLLMLsVWuF.LILNL..VpPFP+PLN..IFVNVALlFhlLMHGhQLALLKSTlPKDu.........	0	8	25	56
+6440	PF06612	DUF1146		Protein of unknown function (DUF1146)	Moxon SJ	anon	Pfam-B_20141 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	28.30	27.60	24.20	23.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.15	0.72	-4.05	27	920	2009-01-15 18:05:59	2003-07-23 14:47:08	6	1	916	0	83	368	1	47.40	37	64.26	CHANGED	LhFIsluaWALpul.+h-phh+ps..+shQsplLhlhloIulGhhVSsFFL	......llhIhluaauLpul.+h-phhKps..pstpl+lLhlFluIslGahVSsFhl..........	0	18	43	62
+6441	PF06613	KorB_C		KorB C-terminal beta-barrel domain	Bateman A	anon	Pfam-B_20369 (release 10.0)	Domain	This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon [1]. This beta-barrel domain is found at the C-terminus of KorB.	25.00	25.00	26.50	25.50	24.40	23.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.74	0.72	-4.52	4	67	2012-10-01 19:11:18	2003-07-23 15:26:40	6	3	57	6	10	53	6	59.80	61	17.01	CHANGED	uDPD+hKKsll.VEHDsRsAtllLNRRPsstGhhal+YEDsGt-hEs-hGslKlshLhEu	....sDPDKLKKAIlQVcHD...sR.PARLlLNRRPsu-GaAWLKYEDDGpEFEADLusVp.LVALlEG.	0	1	5	8
+6442	PF06614	Neuromodulin		Neuromodulin	Moxon SJ	anon	Pfam-B_20438 (release 10.0)	Family	This family consists of several neuromodulin (Axonal membrane protein GAP-43) sequences and is found in conjunction with Pfam:PF00612. GAP-43 is a neuronal calmodulin-binding phosphoprotein that is concentrated in growth cones and pre-synaptic terminals [1].	25.00	25.00	51.40	51.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.32	0.71	-4.33	3	57	2009-01-15 18:05:59	2003-07-23 16:13:59	6	3	36	0	20	47	0	160.20	64	70.86	CHANGED	sKKDEuPuu-uVENKcGEAoTATEAosA-ouKsDEPoKDG.........SoPoEEKKGpGuuDsuoEQPAPQAsss...SEEKsASA.ETESATKASTDNSPS.KAD-APsKEEsKKADVP.hlTshAsTTPAAEDATAKAssQPppETuESSQsEEKpDAVEETKPoESAQQEEuKEEEuKADQENA	...........................pKKDEuP.s.A-GVEKK.GEGsss.TEAAPAsGsKs-E.s.uKAG.........EoPSEEK.KGEG...DsuoEQsAPQAsAs...SEEKA..GSA...ETESATKASTDNSPSSKAEDAPAKEEPKQADVP.AVTsA..AATTPAAEDAAAKATAQPPTETuESSQuEEch.-AV-ETKPpESApQ-EsKtEEscADQEpA...................	0	1	1	5
+6443	PF06615	DUF1147		Protein of unknown function (DUF1147)	Moxon SJ	anon	Pfam-B_20563 (release 10.0)	Family	This family consists of several short Circovirus proteins of unknown function.	25.00	25.00	32.70	53.20	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.99	0.72	-4.14	3	8	2009-01-15 18:05:59	2003-07-23 16:21:12	6	1	6	0	0	6	0	54.50	98	100.00	CHANGED	MYTSLWGHLGVVKANGLLILQTRKPHTGNHLETSGGMVTMVKKWLLLMTFMAGCRGMIY	MYTSLWGHLGVVKANGLLILQTRKPHTGNHLETSGGMVTMVKKWLLLMTFMAGCRGMIY	0	0	0	0
+6444	PF06616	BsuBI_PstI_RE		BsuBI/PstI restriction endonuclease C-terminus	Vella Briffa B	anon	Pfam-B_16289 (release 10.0)	Family	This family represents the C-terminus of bacterial enzymes similar to type II restriction endonucleases BsuBI and PstI (EC:3.1.21.4). The enzymes of the BsuBI restriction/modification (R/M) system recognise the target sequence 5'CTGCAG and are functionally identical with those of the PstI R/M system [1].	25.00	25.00	30.50	30.40	23.20	22.80	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.64	0.70	-5.62	22	135	2012-10-11 20:44:44	2003-07-23 16:25:22	6	3	130	2	34	117	7	280.90	40	82.08	CHANGED	EutpIhhp.uhstp.ps....EpSALs..............s-upp.hhshsshhshtcpthu+.YAsNTREolRcpTl+phl.ushAl........s-psshPssSs+ssYplpsphhsL.........LcuhsoshhpcpLsthhhpRhsLlpphA.spttspIsVphPsGcphpLuPG.pS.LhKsllEpFAPRFhss.stllalu-o......GsKhshhDcpLhpp.LGlslcuctchPDllLh..tcsah......lhlEsVsScGPlstcR+ppLtpLhpsu...pssllaVTAF.sRut..hp+hls-lAWcT.VWhAspPsHLI+h.sGtphltPap	.....................Atpllhpluhsttpps....-puAlshLAlhslp.tptW....ssA......ps.....hlshp.s.lhsahccta.........s.+..........YAsNoREThR+pohHQFhtAslsl.ss-cPs+ss.NSPpssYplpsthlsl.........L+sas......ost....ac..ppLs..saltp+tsLhppaApp+ptsplPVplssGpphpLSPGtpspLh+ulIE-FAPRFsss.uhllYlGDT......upKhshh-tthLtt.LGlslss.HsK...hPDVVLa.ps+sWL......lLlEuVTScGPVss+R+tELtcLhtsu...suGll.aVTAF.sRst...h...p+alu-lAWETEVWlA-tPsHhIHa.NGs+FLGP..........	0	9	24	27
+6445	PF06617	M-inducer_phosp		M-phase inducer phosphatase	Vella Briffa B	anon	Pfam-B_16267 (release 10.0)	Family	This family represents a region within eukaryotic M-phase inducer phosphatases (EC:3.1.3.48), which also contain the Pfam:PF00581 domain. These proteins are involved in the control of mitosis [1].	21.70	21.70	22.70	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.95	0.70	-5.32	8	226	2009-01-15 18:05:59	2003-07-23 16:31:08	8	5	44	1	76	243	0	186.80	32	45.42	CHANGED	LDSPushDsptspE.................hslpphpShsQ+LLGsSPAh+p.osSsuLDp..hp.tD..th.sssENKENEua.FKhP.h+.h....hpuhh.htpt+-hhsQRpsSAP.hMh.Ss.p+h-l...E-ushhhLuoPpo..ssspsss....cED......DGFlDhL-uEpLc--.tsPsu........MtsLhoAPLVhphpc.ptt...hhsRs.tLaRSPShPsSlsRPhLKRlERspDc-sPspsKRR+Ssos..ptc.tcsppP+p...pl...hp.t.SLCchsIEsl	.........................hDpsu.hDsp...p.....................htt.psh..cLhtpSPs.h..opspu.ct........s.....th..s..spsKEN...-s..hK...........................pp.hhpp..ut..........o.s......p..p.....tt.p.h.hh..p.....ssstt.p........................tED......pGF..h-hhps-.l....cs.-....st.........h..LhssPhh.............t.....................s....+s....tLacSPSh.sp....sh...Rs...hLKR..-+.p-ps..P.psK++ps...s.............p....ps.p.p....h............S.sp.pIpph.............................................................	0	4	7	25
+6446	PF06618	DUF1148		Protein of unknown function (DUF1148)	Moxon SJ	anon	Pfam-B_20595 (release 10.0)	Family	This family consists of several Maize streak virus proteins of unknown function.	25.00	25.00	248.80	248.60	21.10	17.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.68	0.71	-4.13	2	13	2009-01-15 18:05:59	2003-07-23 16:45:23	6	1	13	0	0	6	0	114.00	99	100.00	CHANGED	MRSHTPPEGTVIMVVPtCWSVWIWRDGLSALLPALFSPAEEGFFLETRLFQFESSPRFLLDVDMADCLSRAWNKWPGIALTWWCWYIRDRVAPIHSLSTKYpLLRGSALASLQN	MRSHTPPEGTVIMVVPACWSVWIWRDGLSALLPALFSPAEEGFFLETRLFQFESSPRFLLDVDMADCLSRAWNKWPGIALTWWCWYIRDRVAPIHSLSTKYQLLRGSALASLQN.	0	0	0	0
+6447	PF06619	DUF1149		Protein of unknown function (DUF1149)	Moxon SJ	anon	Pfam-B_20513 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	32.30	32.00	21.00	17.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.73	0.71	-4.21	12	561	2009-01-15 18:05:59	2003-07-23 16:47:41	6	1	557	5	40	153	0	123.10	52	97.03	CHANGED	MplhR-pEFVspYHaDsRNhtWEcENGsPETslcVsFQLlcp-cttp.......sTsllslLpFhIVhDc..FVISGhISQhs+lhsRllscPsEhsQ-ElcpLutPLl-hlcRLTYEVTEIALDcPGlsLEF	............................Mpl+R-.pEFVspYHaDsRNhtWEpENGsPETcl-VsFQLlp..c..-pENp.......sTullllLsFhIVFDc...FVISGsISQlNHIpsRlls-sSElsQEEVEpLuRPhlshlpRLTYEVTEIALDhPGlNLEF........	0	5	14	24
+6448	PF06620	DUF1150		Protein of unknown function (DUF1150)	Moxon SJ	anon	Pfam-B_20612 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of unknown function.	25.00	25.00	26.10	36.90	24.30	17.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.35	0.72	-4.16	48	249	2009-01-15 18:05:59	2003-07-23 17:04:49	6	1	246	0	83	175	52	74.80	38	89.73	CHANGED	sphs.t...thussplsYVRslpss-Lspch........splsssppLaAlHuA-GpplALscDRchAFshAppp-hpPVoVH	........h..ho.pphApLGtGclAYVRplcs--lspphPt.....hs.lss.u.hpLaALauAsGpPIsLsDsRpsAhtsAtpc-LpsVolH...	0	21	51	61
+6449	PF06621	SIM_C		Single-minded protein C-terminus	Moxon SJ	anon	Pfam-B_21144 (release 10.0)	Family	This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologues in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerisation partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism [1]. SIM2 is thought to contribute to some specific Down syndrome phenotypes [2]. This family is found in conjunction with a Pfam:PF00989 domain and associated Pfam:PF00785 motif.	21.50	21.50	21.50	21.50	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.76	0.70	-4.83	5	112	2009-09-10 21:39:22	2003-07-24 10:21:55	7	9	43	0	54	89	0	243.70	41	40.29	CHANGED	SPosTu.......sEsRKuuKSRso+sKoKsRTSPYP..QYSuFpsDRSESDQDSsWGGSPLTDoASPQLh-ss-csuo....SCsYRpYSDPtSLCYG.FPL..DcHsLScc+sHhHocsC-...uusCEuuRYFLGTPQuGREsWWcsARSlLPLsKSSPENtcua.ElousHtA.lHslcuRGHWDEDSAVSSsPDu..uGSsS-SGDRa+s-pa+SSPpEPSKhETLIRATQQMIK......EEEsRLQh+KhPs-hsLAspsuLuKuap.......spasQushsusVCRusu.s.......................s..spSPssLSRLSS..PpP..............................Dclo+Ss	.................oshsT........p-sRKhsKs+.op.K..oK.R....Ts.PYP..QYSuFph-+..Es.s.p.upWtuS..PhsssAuPQ..p.t...scsus......hhh.paS...ShpYG.FsL..Dpphhsp.c+..hh.sp....hsp...Gu.CEsuRaFLuT..su.tEs.Wt.upshlP..op.usscsh.t...sshs+hs..s.phcu...uth.t...cc..s.s..s..Ps.....ssut.cptstht.t.http..........p..s.t......shhts....phht...........sph...h..................................................................................................................................................................................................................................................................	0	2	6	20
+6450	PF06622	SepQ		SepQ protein	Moxon SJ	anon	Pfam-B_21060 (release 10.0)	Family	This family consists of several enterobacterial SepQ proteins from Escherichia coli and Citrobacter rodentium. The function of this family is unclear.	22.70	22.70	22.90	23.70	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.06	0.70	-5.53	2	115	2009-01-15 18:05:59	2003-07-24 10:27:28	6	2	105	0	1	46	0	275.20	84	98.26	CHANGED	Mp.LNSQ.NMKINDFYLPLLsVIGhGRLYITsEGHACHAYFREVSGNGhRFTLshSGYEGpFWlSEEQhhQWCpELFPYS-SRLIPEDhIKLMlLWshpssLPEsDsSVDDVQFThLNKDlYPVIENNNGcNRLNVIILchTVQSLQYLIN-NWQhVPHSNTlFFDGYIAPGWTDYPlTcLolGDSLRLYHVDDSpERcCWLVINNPLATVKLsDNNL.lsDVQAAD.LChISNEsVMsRIYCsIGTIpVDIHhLRNhKKDDhIsSsGYHLFGGsRLIRNNThIAYGoIlKINEDFY.slSlVCD	.................Mp.LsSQLNMKINDFYLPLLPVIGTGRLYITScGHACHAYFREVSGHGIRFTLTYSGYEGRFWISEEQFIQWCQELFPYSESRLIPEDhIKLMILWV...MQTALPE.GDVSVDD...VQFTMLNKDlYPVIENNNGENRLNVIILETTVQSLQYLINDNW......QFVPHSNsLFFDGYIsPGWTD...YPVTEL...pVGDSLRLYHVDDSpERcCWlV.INsPLATVpLsDNN.L..lsDV..AADLLsslSNEsVMsRIYCsIGTlHlDIHMLRNsKKDDIIsSsGYHLFGGCpLIRNNTTIAYGSIVKINEDFYFTVSlVCD.....................................................	1	0	0	1
+6451	PF06623	MHC_I_C		MHC_I C-terminus	Moxon SJ	anon	Pfam-B_21327 (release 10.0)	Family	This family represents the C-terminal region of the MHC class I antigen. The family is found in conjunction with Pfam:PF00129 and Pfam:PF00047.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.72	0.72	-6.86	0.72	-4.47	14	3480	2009-01-15 18:05:59	2003-07-24 10:35:40	6	6	87	0	199	3309	0	27.80	76	7.99	CHANGED	NoGGKGGsYs.AsupDSuQuSDVSLsssK	.........S.SGtKG....GSYSQ........A.ASSDSAQGSDVSLTA.............	0	71	71	72
+6452	PF06624	RAMP4		Ribosome associated membrane protein RAMP4	Moxon SJ	anon	Pfam-B_20959 (release 10.0)	Family	This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER [1].	21.00	21.00	21.00	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.85	0.72	-4.43	16	291	2009-01-15 18:05:59	2003-07-24 10:42:24	7	7	191	0	175	245	1	60.90	43	70.61	CHANGED	MuusQRM+htNcpaspNlspRGNVPKSh+sp.-cKaPVGPhLLuLFlFVVCGSAlFQIIppIph	..............................sppRh.+.h.uNcK.a.s.K..N.l.T...p.R...GsVscop...+p.....p...p...p...chPV.GPhLLu...lFlFVVsGS...ulFQIIpshp............	0	57	96	143
+6453	PF06625	DUF1151		Protein of unknown function (DUF1151)	Moxon SJ	anon	Pfam-B_21020 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function.	25.00	25.00	31.80	31.00	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.79	0.71	-4.38	9	174	2009-01-15 18:05:59	2003-07-24 10:44:28	6	3	74	0	98	151	0	114.10	50	72.76	CHANGED	hucPshl-ssssELIhP+KLlNPstsSts+Q-LHRELLhNpKR.GLslppKPELQ+VhEKRKccpllcppc..EEpptp+.....o-LEpELh+RpQ+L...EphEhcptp.pEEpcp.....PEFl+V+upLR+	.................AcP-Yh-tsss.ELI+P.+KLlNPVKsSRsHQ-LHRELLMNpKR...GLuhpsKPELQ+VhE+R+RsQl..lKp+c...EEtpt++.........osLEtE.Lh+RQQ+L...-QLE.pptt.p..EEpcs........PEFl+V+tNLRR...................	0	15	29	60
+6454	PF06626	DUF1152		Protein of unknown function (DUF1152)	Moxon SJ	anon	Pfam-B_21029 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of unknown function.	20.60	20.60	20.70	21.80	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.90	0.70	-5.30	14	77	2009-01-15 18:05:59	2003-07-24 10:46:02	7	3	71	0	40	74	6	273.70	29	79.54	CHANGED	LllulGGGGDVVuAhslsthltp...G.csslGslsWERhVhDPhPGPlshsplpp.sptlsctlhlssscoashRGGRhhhsQsspsucsLspp.V..ahlD.hcGsptlscuLpchhth.thDtllGVDsGGDlLApGsE-sLtSPLADulsLAsLs+lc....puhLtVhG.GuDGELsh-YllpRlu-lA+pGGhluhhGlscpssclLccllchssTEAStlslt.Ah+GcaG.hpIRsGsRpVhlsshuslhFhhDPpslhphsphA+ll.csotol-EAsctLp.phGlhTElchEcsL..Apt	.......................................hhhuhGGGGDlhsuhhhhthh.t...t....pshluslsW-Rhh..DPhPG...Ph.hpphpt..h..lsttlhhls.pshs.t...ssh.hhsphsp..hhp..hht.....hhhlsspsGs.....psltculcphhpphthDtllhVDsGGDlLucGsEpsLtS...PL...tDuloLAuls.plpt......sshlsl.hG.GsD..G..E..LstshlLppluclspt..sGhLuhhul..sp.........p..s......s......p......h......l......cp....ll.......p...p.sso....E.A....Stl...s.......ht...Ah+Gh.aGph.....pl..Rsus..p..plhlsslsulhahhD.pt.l.hpts.hhphl..psotslc-Apphlp.thsh.oEhphE..h...t.....................	1	19	28	35
+6455	PF06627	DUF1153		Protein of unknown function (DUF1153)	Moxon SJ	anon	Pfam-B_21038 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	23.50	23.50	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.98	0.72	-4.12	22	282	2012-10-04 14:01:12	2003-07-24 10:47:34	6	1	259	2	92	204	26	84.70	58	93.15	CHANGED	Mah+KhpGP+tVsLPDGoshTpADLPPssT+RWVApRKAuVVcAVttGLlot-EAhcRYsLS-EEFtuWtpAlscHG.suL+sT.plQcYR	...................psp.+hVIGPDGoPLTlADLPPssT+RWVlRRKAEVVAAVRGGLLSl-EACpRYsLTsEEF.hSWQpuI-cHGhsGLRsTRIQpYR..............	0	24	58	71
+6456	PF06628	Catalase-rel		Catalase-related immune-responsive	Vella Briffa B, Coggill P	anon	Pfam-B_16304 (release 10.0)	Family	This family represents a small conserved region within catalase enzymes (EC:1.11.1.6). All members also contain the Catalase family, Pfam:PF00199 domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects [1]. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells [2].	20.90	20.90	20.90	21.50	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.86	0.72	-4.11	343	4316	2009-01-15 18:05:59	2003-07-24 10:55:15	7	11	2870	287	1207	3539	63	67.50	25	12.26	CHANGED	chctsp..D.pasQssthap.sh..sssE+p+llsshstpL....upsspt....lppRhls.hhtpsDsshuppVA.cuLs	..................p.tpt.-.pasQstthap.sh....sst....-....+p+.l.....hsshutpL....spls.ct......IppR.hls.hhtcs.DsshuptVAcsLt...........	0	326	674	986
+6457	PF06629	MipA		MltA-interacting protein MipA	Moxon SJ	anon	Pfam-B_8359 (release 9.0)	Family	This family consists of several bacterial MltA-interacting protein (MipA) like sequences. As well as interacting with the membrane-bound lytic transglycosylase MltA, MipA is known to bind to PBP1B, a bifunctional murein transglycosylase/transpeptidase. MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complex [1].	21.00	21.00	21.00	22.80	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.07	0.70	-4.94	16	1671	2012-10-03 17:14:37	2003-07-24 11:34:39	7	3	1070	0	339	1085	89	223.70	28	84.76	CHANGED	phslGs...uushssc..h.uu.cchpltshPhlshptts....hhhcssshuhtlhsssshpluhssthshstt.....csssptt........ptlss.................+cushssGlthth.hs.hplpsphp..tsl.ssscGhpsslshshshplu..phplssuhulsatsppasptYaGVssppuAtSsLsp.YsusuG.hsssluhsspYhls-phshtstsshoRLtusstcSPlVccchphshhhu.......hsYpF	........................................................................................................................................t.holGu...G..s.uhspp....acs....c..p.s..s.h...s..l..P..l..l.s..Ycu-s...............Fah.c.s.......h.....s........h.....G..a..h.L....h.....p..s..s.....s.....s..p.....lul..s.uh....a....ssh.th...........................cs.sc..ss.ctth..........................ptL-c.........................................Rc.u..oh..h.uG.l.u...h......t...a.....h...p......p.....a.G....h....l.c..s.s..hs.........sDs..h....s...s..u...s......G.......h....s.......h.......c.......h.u.hh...a.p.h.p....hu............sh......s...l.oPulGl..pasocs..hscYYYG.VoppE.u...s......+.........S........G.....l.....tu...Y.....s...s...s.s..u...as...sh..lp.lous.Y....s..hs....tc.....W.....s.....lhusupYo..+L.s.s-.l.s.D.SPh...V-...+....sh...sh...hh...ssG...loYcF....................................	0	55	144	243
+6458	PF06630	Exonuc_VIII		Enterobacterial exodeoxyribonuclease VIII	Moxon SJ	anon	Pfam-B_11449 (release 9.0)	Family	This family consists of several Enterobacterial exodeoxyribonuclease VIII proteins.	25.00	25.00	28.90	28.40	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.14	0.71	-4.95	4	316	2009-01-15 18:05:59	2003-07-24 11:35:34	6	4	227	0	12	263	0	174.40	44	23.76	CHANGED	huhh.hhhscKA+Kp.G..suhhWsoschEuss.ApLshhllcuGhc.sDahKsVtsNhPVVN-LPPEGphDhTFCp+YpLu.cDuhTahhIPGs..PuosAtDps....sssssTp...sGEDhTE....EEN..h.lS........stpLPlRahs.H.....hTasupDth.hhHlsRApc..tlTsLthspcsShlpsL	.......................................................shhs.hhscKs+Kp.G.KsuhhWsosch.Ssu.uphshhhscuGhc.....cDahKsVtsNhPVVNDLPPEG.hDhpFCsRYphu.cDuhThhhIs.hs..ss.s.ss.t-ps.......................ssss.NTs....hsuEDhoE............hE-s...h.lS.....................stpLPlRahs.H.....hT.asupDth.thHlspspc.ssVTALthspcsShLpsL................................................................................................	0	1	2	7
+6459	PF06631	DUF1154		Protein of unknown function (DUF1154)	Vella Briffa B	anon	Pfam-B_16329 (release 10.0)	Family	This family represents a small conserved region of unknown function within eukaryotic phospholipase C (EC:3.1.4.3). All members also contain Pfam:PF00387 and Pfam:PF00388.	19.80	19.80	19.90	19.90	19.30	19.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.33	0.72	-4.30	11	207	2009-01-15 18:05:59	2003-07-24 11:38:13	6	15	89	0	109	225	1	45.30	44	4.24	CHANGED	+c..shsPlslEsL+ppKuahKlhKKQQKEL-oLKKKHsKE+suhQK	........h......ltshslE-LKQpKualKlh...KKQpKELcsL+KK.HtKcpsshp.......	0	23	31	68
+6460	PF06632	XRCC4		DNA double-strand break repair and V(D)J recombination protein XRCC4	Moxon SJ	anon	Pfam-B_21077 (release 10.0)	Family	This family consists of several eukaryotic DNA double-strand break repair and V(D)J recombination protein XRCC4 sequences. In the non-homologous end joining pathway of DNA double-strand break repair, the ligation step is catalysed by a complex of XRCC4 and DNA ligase IV. It is thought that XRCC4 and ligase IV are essential for alignment-based gap filling, as well as for final ligation of the breaks [1].	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.14	0.70	-5.59	5	165	2010-01-05 15:47:52	2003-07-24 11:41:38	7	2	131	30	88	172	0	255.40	26	82.27	CHANGED	MERKVSRIsLoSEPslsaFLQVuWEKTLGSGFVITLTDGHSAWTGcVSESDISQEADDMAME+-KYVDELRKALVuuAGPA.....ssYsFsF.....SKEopaFSaEKsLKDVSFRLGSFcL-KVsNPAEVIRELICYCLDTIAEpQAKNEHLQKENERLLRDWNDlQGRFEKCVsuKEALEsDLYpRFILVLNEKKAKIRSL+.chLsElQEhEK..slKpKpETo.......ssSDposDcDulYD...GSTDEEsEuPsss.........................StpsPAsls+DDSLlSS.DlsDIAPSRKRRQRMQKNLGTEPKhAoQEpQhQEKEKsssusPposKK-tsSAEsMSLETLRNS.SP-DLFD	...............................................................................................................................................h.-s.s..sa.sphp.t.lt......ttt.t....tp...aht.htphh...t.ss............apht...............sp.p...ph.h.hc...K.ph..p..s.l....ph....RL..G.s.h.pLppstss.sp.hlp.........-.lhsas...lsshsc.ps..csp...c...L..pp....cs...-...+...L........p...-h...s...clp...sphE+hlssKcthEs-Lap+FlhVLNEKKsKIRsLp.ch...L.....sp.....sp...p..pc.....shppc..t.pss.................hps..c.sss.cc....s............D......t.o...s.c-c.p.pt.........................................................................................................................................................................................................................................................................................	0	20	38	62
+6461	PF06633	DUF1155		Protein of unknown function (DUF1155)	Moxon SJ	anon	Pfam-B_21101 (release 10.0)	Family	This family consists of several Cucumber mosaic virus ORF IIB proteins. The function of this family is unknown.	25.00	25.00	86.00	85.80	20.70	17.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.28	0.72	-4.69	2	5	2009-09-11 08:20:59	2003-07-24 11:44:03	6	1	1	0	0	8	0	41.00	79	91.52	CHANGED	MSATLSTTLSFEPPLSLLAEPGTWFADTMDFc+pp.lthhpp	MSATLSTTLSFEPPLSLLAEPGTWFADTMDFRKKHSVRWYpp.	0	0	0	0
+6462	PF06634	DUF1156		Protein of unknown function (DUF1156)	Vella Briffa B, Eberhardt R	anon	Pfam-B_16387 (release 10.0)	Family	This family represents a conserved region within hypothetical prokaryotic and archaeal proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	21.20	21.20	24.20	22.70	20.50	19.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.25	0.72	-4.22	43	252	2009-01-15 18:05:59	2003-07-24 11:47:17	7	11	214	0	122	263	47	69.50	31	7.82	CHANGED	sslPlcpIsttut+EKph..ppG.phosLHhWW.ARRPLuusRAllhAuLls.....................t.th-tpphhpll	.......shPlptlsttut+E+ph..ptu.p.psLHhWW.ARRPLussRAllhAsLls................................t.chp.h.......................................	2	53	89	106
+6463	PF06635	NolV		Nodulation protein NolV	Moxon SJ	anon	Pfam-B_21143 (release 10.0)	Family	This family consists of several nodulation protein NolV sequences from different Rhizobium species [1]. The function of this family is unclear.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.41	0.71	-5.16	2	48	2012-10-02 21:03:42	2003-07-24 11:47:37	7	1	43	0	13	247	7	191.10	32	93.17	CHANGED	MTADh.ssPAAPphRsLGPLIPAupLEIWcsAhpAhAAAERH.Q+VRuWARhAYpREhApG+sEGhpAGAEEMAtLIuQAssElApRKAVLEppLPQLVhEIlp-LLGAFDsGchLV.sVRHAIEppYpssEVCLHV.PhpsDhLApEFtsaDG.-GRP+lRIcsDPsLSscpCVLWSEaGNVDLGLsAQhRALRLGFG.LoEcuE.	..................................................t..h....................ll......As.pht.hh-Ah.thlsAA.+ccA..ppl+......spA..p.p......t.......aE...p.p.R..A....c....Gac-G.h...p.p...G........sc........c....h.......A..t.......L....l.......A..p....s.......s.....u....c....s.......s........c..h.h.......A.......s...L.......E...p....p....lsp.......L..V...lph....lRpl....L.G...t..h..D.....s..p...E..hll.+.s.lppAl...st.h.tps.p.p.lsL+VsP.s.c.V....-...hL....p.p.ph....s..p..h..s...s........s.h....p.l.pI...sDspLusspClLtophGsV-hGL-sQLcALRhuh..........t.......................................................	0	3	6	9
+6464	PF06636	DUF1157		Protein of unknown function (DUF1157)	Moxon SJ	anon	Pfam-B_21250 (release 10.0)	Family	This family consists of several uncharacterised proteins from Melanoplus sanguinipes entomopoxvirus (MsEPV). The function of this family is unknown.	22.70	22.70	23.20	475.70	18.10	22.60	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.27	0.70	-5.86	5	5	2009-01-15 18:05:59	2003-07-24 11:49:41	6	1	1	0	0	5	0	367.40	38	96.28	CHANGED	IYFV..IVGIIFlIaaIIasl....NpYlshhpNs.NaNhos.hhppls......lspc.hl-FhIIpGSh.-NlIlsRshDGlQslKlIPTFVFLoNalps-lIsYGGF.NsoLsFPsNNIhN+S.sWIYGGWFIluNGNGDaICV+SNN.sNI+RaNcscsllKaL..sYNsucsN.....DsIIloNIlYKhc.EIlLINIscIussNs.ss-YYsILGNILlYIKsNaINDKpFIIsGpsGLNSKYIpLAI-TIF.lDslISSCYDGuITYVcNN.lasQSSFIlIDKcLCPYGVRFGlRY.LENshspaNLlLYATIYNcNpcspplEYFNDcLSINIFESIKSpsNYsDcYVNW-cIDISsLssNFE.sslsLlDDss.oYo+cpL-sIlNK	IYFV..IVGIIFlIaaIIasl....NpYlshhpNs.NaNhos.hhppls......lspc.hl-FhIIpGSh.-NlIlsRshDGlQslKlIPTFVFLoNalps-lIsYGGF.NsoLsFPsNNIhN+S.sWIYGGWFIluNGNGDaICV+SNN.sNI+RaNcscsllKaL..sYNsucsN.....DsIIloNIlYKhc.EIlLINIscIussNs.ss-YYsILGNILlYIKsNaINDKpFIIsGpsGLNSKYIpLAI-TIF.lDslISSCYDGuITYVcNN.lasQSSFIlIDKcLCPYGVRFGlRY.LENshspaNLlLYATIYNcNpcspplEYFNDcLSINIFESIKSpsNYsDcYVNW-cIDISsLssNFE.sslsLlDDss.oYo+cpL-sIlNK...	0	0	0	0
+6465	PF06637	PV-1		PV-1 protein (PLVAP)	Moxon SJ	anon	Pfam-B_21397 (release 10.0)	Family	This family consists of several PV-1 (PLVAP) proteins which seem to be specific to mammals. PV-1 is a novel protein component of the endothelial fenestral and stomatal diaphragms [1]. The function of this family is unknown.	22.10	22.10	22.30	22.10	20.70	21.70	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.58	0.70	-5.91	2	56	2009-01-15 18:05:59	2003-07-24 11:54:25	6	2	31	0	29	44	0	320.80	46	79.83	CHANGED	MGLuM-+.usYARsGsppRGCWYYLRYFFLFVSLIQFLIILGLVLFMlYGNVHsoTESsLpATEhRA-uLYSQllGLoASQuNLoKpLNhohhsK-slMQ.hLssRR-h-RINASFRQCQGDhlhYhN.pRahAAIILSEKQCp-QhK-hNKoC-ALLFhLspKVKTLEhElAKEKslCoKDKESlLhsKR.sEEQL.tCsKsREhQpQEpQlscEpLpKVQuLClPLDp-KFphDlhshWRDSlI.RoL-sLsY..aa.LhsEhASlRRsC-phPulMooKlEELARuLRAsIERVsRENu-LpRQKLEhppuhpAuQEA+t+stpEAQAREspLpAECuRQTQLALEEKAsLRtpRDNLt+ELEt+KREhEQLRhElslR.SALDTClKsKS.PhhPs.Rs.GPsPNP.PIDPASLEEFK++ILESQR.Pss.PsA.sSG	.......................M-+.usY.R....sG.....s...ps+GCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNs.HsoT.E.upLps..TEpRA-sLhupllsLpuppsNLoK-LNlTspuK-ul.QhllssRR.......DL-RINASF+Q.CQ...s-hh.a.sp.+ahsAIlhSEctCtp..php-hNpoCpuhhhhLtpKsK..sl..EhEh.ppKhlCsK-K-u.hhhsKp.s.EpQhttC.sctpt.p.QEhQlsptpLppVpshChslDppKh..ph.plWR-Sll.+sLssh.....sa..ahs..s-.....h.tlp+.CcphPtlMtsKlppLAptL+hsItpVstENtclpRQK.thppshtuspctttt..pEsttp......phpt-ss+QspLALEEK.ssLpcc+-tL.+pLEt+c+phtthphplslp.tsL-sCl+sK..........................................................................................................................................................................................................................................................	0	1	5	12
+6466	PF06638	Strabismus		Strabismus protein	Moxon SJ	anon	Pfam-B_9849 (release 9.0)	Family	This family consists of several strabismus (STB) or Van Gogh-like (VANGL) proteins 1 and 2. The exact function of this family is unknown. It is thought, however that STB1 gene and STB2 may be potent tumour suppressor gene candidates [1].	25.00	25.00	28.40	25.90	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	505	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.80	0.70	-6.19	10	386	2009-01-15 18:05:59	2003-07-24 11:55:16	6	3	160	0	106	275	0	335.00	52	94.50	CHANGED	H+-R.pR-RH+s.pS+.....cspSRu-KSVsIss....P.spPhhsus.............sstpht.-sQDDNWGETTTAVTG.TSEcSISpEDlsplsK-hEDss.shsCcRYLGhulushLGLLAhlTPlAFllLPplhW..............R-cLcsCGssCEGLalSLAFKLLILLIuoWALFhRps+AslPRlFlFRALLllLlhLhs.hSYWLFYGVRlL.cu+........-csY+GIVpYAVSLVDALLFIHYLAlVLLElRHLQPtFslKVlRSTDGESRaYslGpLSIQRAAVWlLEpYY+DFPVYNPsL.sls.....KpRtuK+huGFKVYsV...DGs.ssss.suQSRAhlAAAARRRDsSHNEhYYEEAEaERRVRKR+ARLVsAVEEAFTHIKRh.........psE-p.....t.Psp.MDP+EAAQAIFPSMARALQKYLRoTRQQshHTMESILpHLAFCITHsMTPKAFLEpYLssGPTlQYs+-pttscpWTLVSEEsVTsuL+cGssFpL+psDFSLlVTV++IPal+LoEEaVDPKSHKFVL+LQSETSV	.....................................................................................................................................................TTA.........VT.G..TSE.tS.ShED.lu...p.hsh-.............pDo...s...G...h...s.C...pRYhGsTV.A....h.sL.uh..luFloPlAh....llLPpl.h.a..................h.p.L.sCsstCcGlhlSlAFKLllLhIGhWAl......F..h.R.....p.p.uslPRlFVFRAhhLVllhlhs.hSYWLFYhVpI....-up................sh.sYp....ul.V........pYssShsDsLlFIHYluVlLhEl.Rp....L..pPhahlKlVRSsDGESR.YslGpLSIQRAAlalLpp.YYp-Fsla................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	31	38	66
+6467	PF06639	BAP		Basal layer antifungal peptide (BAP)	Moxon SJ	anon	Pfam-B_21444 (release 10.0)	Family	This family consists of several basal layer antifungal peptide (BAP) sequences specific to Zea mays. The BAP2 peptide exhibits potent broad-range activity against a range of filamentous fungi, including several plant pathogens [1]. 	25.00	25.00	26.10	25.80	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.54	0.72	-4.27	3	15	2009-01-15 18:05:59	2003-07-24 13:29:27	6	1	4	0	4	14	0	74.00	36	76.60	CHANGED	MlLLASFVuHA+IISGETKEsSNTRSMTMT.TRuuuplIluDNKsuLCYLDuthLEYlC++Tp+CY+oLKcCLEaC	.............................MlLLAS..hVhHAphlsGps+EsoNstShTMT..T..puusphllu.....-scsulCYL....cuh.hhYsCc+Tp+CY+sls-CLt+C	0	0	2	3
+6468	PF06640	P_C	P_prot_C-term; 	P protein C-terminus	Vella Briffa B	anon	Pfam-B_16385 (release 10.0)	Family	This family represents the C-terminus of plant P proteins. The maize P gene is a transcriptional regulator of genes encoding enzymes for flavonoid biosynthesis in the pathway leading to the production of a red phlobaphene pigment [1], and P proteins are homologous to the DNA-binding domain of myb-like transcription factors [2]. All members of this family contain the Pfam:PF00249 domain.	20.00	20.00	20.00	28.60	18.80	19.80	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.74	0.70	-4.34	5	26	2009-01-15 18:05:59	2003-07-24 13:58:00	6	4	9	0	7	24	0	179.70	52	62.13	CHANGED	AIAIDMSKLQSA-+RRGGRTPGRSPKoSu............o+oKQsDsDpPGsEAtuss.............uAASSPR..HSDtAR..SsVVDP-..PNQPN.SSSGSTGss.EtssSuEDATGPWlLDPIELGDL.W.EAES...EMDALMsIGssupDuAslEGL-Al..sspAQVDDLF..DMDWDGFAAHLWGGPEQp.DHuA..plQQAAEPpssAu..........................tAuAAuAsuCoPDE+cLEAFEoWLLSDSF	............AlsIDhSKLQSA-+RRGGRTP..GpsPKuus............p+sKpsDsspPttcAt.uss.............uuASSPR..pSD.......VVsPs..sNQPN.SSSGSsGss.-tssSpEDAoGPWsL.-Pl.E.hGDL.W.EA-S...........EMDALhshGssu.DusslpGltsl..sspAQsDDLh..DMDWDGFAAcLWGsP..t...p+uu...lppAuEP.....................................sshusssD-..LEuFtoWLLSDSh........	1	0	4	7
+6471	PF06643	DUF1158		Protein of unknown function (DUF1158)	Moxon SJ	anon	Pfam-B_21508 (release 10.0)	Family	This family consists of several enterobacterial YbdJ proteins. The function of this family is unknown	25.00	25.00	31.80	83.20	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.92	0.72	-3.66	3	460	2009-01-15 18:05:59	2003-07-24 14:09:29	6	1	452	0	20	95	2	79.10	88	99.95	CHANGED	MKHPLETLlTAAGILLLALLSCLLLPAPSLGLTLAQKLVshFHLMDLNQLYTlLFCLWFLLLGAlEYYVIRFVWRRWFSLER	.....MKHPLETLhTAAGILLMAFLSCLLLPAPALGLTLAQKLVohFHLMDLSQLYTLLFCLWFLVLGAIEYFVLRFIWRRWFSLAD...	0	1	1	11
+6472	PF06644	ATP11		ATP11 protein	Moxon SJ, Hammonds G	anon	Pfam-B_21093 (release 10.0)	Family	This family consists of several eukaryotic ATP11 proteins. In Saccharomyces cerevisiae, expression of functional F1-ATPase requires two proteins encoded by the ATP11 and ATP12 genes [1]. Atp11p is a molecular chaperone of the mitochondrial matrix that participates in the biogenesis pathway to form F1, the catalytic  unit of the ATP synthase [2].	22.00	22.00	22.40	23.10	20.20	21.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.85	0.70	-4.90	22	313	2009-01-15 18:05:59	2003-07-24 14:22:25	6	7	259	1	214	313	1	231.70	28	77.06	CHANGED	hptppsshhc+YcsKlpphupppshpslp....cLcpthcp.............................ppt.tshsppspphpshct..s..s......st.ts...........KsLsShlclE+lcshstcE..lctlWcthat.....pcsslsAslP.h-pYcthhspA+psPhFlLPLPRp.................pGhEhaalQWp......................ssphlFTsLtpYKl+t-hAtPahslpaah-Lsp-KslVLMpGplpscst.............losp-AQhLh.slQpFY.............sttspp+hpLLcsFs+ts.pcFchpcllp.h	...............................................................t....t.h.t+YtpKl.phtpp..s......p....tlct.....................................................................................t...t..t.........t...................................s.....................................KsLsslhclchlcp.h.ss..cE...lptlWpthat......spps.lsAsls.sppapthhspAppsPhFllPLPRp............................pGhEhahhQat.....................................ssplhFTsLtpYp...h+s.-hAtsphslpaas..-.Lt..............c............pK.........GlVLMpGph...ssh..................lssp-AphLs.plQhFY....................tptsppphpLlcpFspts.ppFchppllpp.h......................................	0	68	118	178
+6473	PF06645	SPC12		Microsomal signal peptidase 12 kDa subunit (SPC12)	Moxon SJ	anon	Pfam-B_21331 (release 10.0)	Family	This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12).	21.40	21.40	21.40	22.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.54	0.72	-4.17	30	303	2009-01-15 18:05:59	2003-07-24 14:34:31	8	4	253	0	216	311	3	76.70	32	70.93	CHANGED	MDFpGQ+hAEplhplllslsulluhllGYhhQphuholalhhsGhslosllslPsWPh.Yp+pPlpWtpstsp.........sscp	..........hDapGQ+hAEplhphllhhs.............ul........l...uFlhGYhhpshphslalhhuGhslosLl..slPsWPh.Y.p..+pPlcWhsst.t......sptt...........	0	73	122	179
+6474	PF06646	Mycoplasma_p37		High affinity transport system protein p37	Moxon SJ	anon	Pfam-B_21350 (release 10.0)	Family	This family consists of several high affinity transport system protein p37 sequences which are specific to Mycoplasma species. The p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria.It has been suggested that p37 is part of a homologous, high-affinity transport system in M. hyorhinis, a Gram-positive bacterium [1].	20.10	20.10	20.20	22.00	19.60	17.70	hmmbuild  --amino -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.08	0.70	-5.41	6	52	2012-10-03 15:33:52	2003-07-24 15:07:28	6	1	48	5	17	60	2	353.50	34	84.94	CHANGED	sKFhcsaSpphs.KLccs........cVslohsh.lDDutoplsslposps..DFAFlsSpulso...Ns.pchsshlQTLTsuFKFDpshD.aYsDGs....LcphAcchsplFscs....P.YpsWsDEsQ............cWsGs+YpFlY..-P.scLlsFYRGMILIsGo-pplspIKcAWNpKNWssFpNaGIh.pGposSuG+ahL.-pLl+KHFs.tp.s..sLtpDhsssPsKYpssp...GR-IGpsssh+IsFDDtsSFAWTcNcpsups...YsPp.............pNsKlEILohT-PhlYDIGlFsKslspchtshIuEsFIpLAKsspDhYGPslGYNGY+hIsDFsKEVlclhpKAhG	............................................tFhc.hpppFN.cL.Kptp.tp+ph.cVphslps.spDp.pshlspL.psscs.....Dluhssssphls..........pspppsls..tl......QTt.ThtFpassss..sthYpDGs.p.pDsLRp......hAcctsclasch....s...YssWp..-pp...p............pasGs+Yp.hY....c.s...sc....lsp.aYRGhIhIs..G...s-..psppcIhKAW-sKcW-sFhpaGIl.au.cssSuGKY+hp.sLl++HFs...pphs......slpp....Dhp.pp.....spYhstt...........uspl..Gp..p..s....c.........h.......+......IuFDDE.G.S.a..u..WTcscpsupp.....apssc...................................................p.NsplchLTlTsPhsYD...lslh...c.p...u...lscpplcLloculhsLupsppso.YGshsGYN..tYp..hIps.p...hhp.htt................................	0	9	15	16
+6476	PF06648	DUF1160		Protein of unknown function (DUF1160)	Moxon SJ	anon	Pfam-B_21501 (release 10.0)	Family	This family consists of several hypothetical Baculovirus proteins of unknown function.	21.40	21.40	21.40	22.60	19.90	21.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.56	0.71	-4.34	14	51	2009-01-15 18:05:59	2003-07-24 15:13:58	6	1	49	0	0	44	1	123.50	30	93.34	CHANGED	FlsplhpshshssKVAhVstpLcpaLp-ht..pD-pFppKhhpllcMFlspcIsl-slhsllsuVDuh.cLTcpQI-YLssplatNppllpIlpsFl-tp+Ls---Is-lupFLVpElssAhhYp	..................................FhsplhpohshssKVuhVphplppaLp-hp...pDcsFppKhppllpMFlppclss-slhslhsssDsl.cLocpQl-YLhsplhpN..........splhpIlpp..al......c........tpc........L........sc--.lstlupFLVpchspA....t............................................	0	0	0	0
+6477	PF06649	DUF1161		Protein of unknown function (DUF1161)	Moxon SJ	anon	Pfam-B_21545 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of unknown function.	25.00	25.00	37.10	43.10	18.70	17.70	hmmbuild  --amino -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.46	0.72	-4.04	24	623	2009-09-11 10:51:00	2003-07-24 15:16:02	7	1	568	0	68	233	4	53.30	70	55.37	CHANGED	CEclKu-IptKI.ANGV..ouaTLEIVsN-pss..........ssupVVGpC-ssT+KIlYpR	.CERlpSDIsQRIINNGVPtouFTLoIVPNDQVD.Q................PDSQVVGHCANDTHKILYTR.	0	5	17	44
+6478	PF06650	DUF1162		Protein of unknown function (DUF1162)	Vella Briffa B	anon	Pfam-B_16458 (release 10.0)	Family	This family represents a conserved region within several hypothetical eukaryotic proteins. Family members might be vacuolar protein sorting related-proteins. 	20.30	20.30	20.30	20.30	18.70	20.20	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.96	0.70	-5.19	39	689	2009-01-15 18:05:59	2003-07-24 15:23:28	7	58	271	0	493	739	4	250.30	20	8.17	CHANGED	hplslauPYhllN+TuhsLthcscshttpstsp.s.............................chttPhhFSFsc.s...tpps+shl+lsc.op........WSp.....shShDulGsstplth.sssp.p...........................................tth....lGlslppGpGcYth...TKlVTluPRallpN+hs.slpltE.ss.........p.......ph....................h.pltssp..................................hhPhahh.ppstp.ppLs....l..ph.t.....ssp....WSusFtlscl.ushal+l..........................................hp..t...sstpthl+l-lhhcsuThFlphsstppp.hPaplcNh...o..............................cpp.hhaaQpss...p.................thp.hthplsPpshhsYAWD.Psutp	.............................................................................................................................................................................................................l.lhsPYhhlNcT.s..h...L.hp.t.p..t............t.........p..................................................................p...shha.......satt..p...........ptsts.lpl....sp.ut...........................................WSp..........h.uh......-....shu.......s.h.t.tlhh......t.tpt.......................................................................lG.lslp...upt....p....h........T+lVoh...s......P+allp.Nc..s....s.h.pl.phtp.ss............p......ph.......................................................h.plts.sp...............................................................................................p.h..sh.ah.......pt.s.tp....ph.lp..........l.....ph.t.......spp........................WS.ts.Ftls.c....ss.....h..hlpl.................................................................................................................................................................................................................................................................................................tpp.t...h...lpl-l.t...h.....p.....t................s.................o....h................h......l.php....p..p..p..t..........P.hhl.Nh...o..............................p...l.ahQt..........................................................h.l.Ptp....h.asWs.Phh..t..............................................................................................................	0	190	271	399
+6479	PF06651	DUF1163		Protein of unknown function (DUF1163)	Vella Briffa B	anon	Pfam-B_16509 (release 10.0)	Family	This family represents the C-terminus of hypothetical Arabidopsis thaliana proteins of unknown function. 	19.40	19.40	22.40	75.80	18.60	17.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.34	0.72	-4.43	6	20	2009-01-15 18:05:59	2003-07-24 15:30:57	6	1	2	0	17	20	1	68.50	55	39.95	CHANGED	hsGlIsKsIMcDIKERp-lRFGSRLhLPDCRcsTsGpMsYsCDEspLRFEPGSppKAThFsc.aPpChhl	.hsGlIsKcIMcDIKE++EV+FGSRlhLTDCRcsToGsMsYsCDEssLRFEPGSEhKAT.hFGs.aPpCh.h.......	0	6	6	6
+6480	PF06652	Methuselah_N		Methuselah N-terminus	Moxon SJ	anon	Pfam-B_3337 (release 10.0)	Domain	This family represents the N-terminal region of the Drosophila specific Methuselah protein. Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [1]. This family is found in conjunction with Pfam:PF00002.	21.50	21.50	21.60	21.70	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.64	0.71	-4.72	10	146	2009-01-15 18:05:59	2003-07-24 15:38:27	7	8	23	6	75	182	0	156.10	28	34.30	CHANGED	CsaaDTVsIScup+L.NGSYlYEsllIPA+LTGcYDF+llsDGs+hpVp.cHlRGCVCKLKPCIRFCCP+cplhss..upChsshs-..pLschc...Pal.slTLsDGSlsph.....+hps-hlVpp-..pP.C-cMasLsc.pphhDcaoL...........FENGolhR+hD.phhLsKpEYCLpPhpa...sssSl..cIhP+sC	.......................................CsahDTVslot....th..........suSY.apslllPsph..h..u...Ysa.hh...ts..p..s..pH.l.RGC....sCpl+sClRhCC.P.tphhst.....spC.sshpp....hhthp..shl.slT.h.s.sso..s.ph.....chhpchh.lppc...hP.Cp..ch..a....h...lsp........pasL...........a.ENGolh+p.D....p.thlspp-YClt.h.h.....sp...sh....lhsh.C.........................................................	0	14	17	58
+6481	PF06653	Claudin_3	DUF1164;	Tight junction protein, Claudin-like	Moxon SJ, Coggill P	anon	Pfam-B_21553 (release 10.0)	Family	This is a family of probable membrane tight junction, Claudin-like, proteins.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.11	0.71	-4.52	24	100	2012-10-03 00:20:40	2003-07-24 15:41:17	6	4	7	0	96	107	0	156.80	19	88.16	CHANGED	Mth...................lhhlshh..lhluhlhshlulFo.sWhs.psh.................shGllPa.s.....s......ahshuuhhhalohshhhhhh..lhhhhshtplp+pGastphRphFhhIuhhshllslLplsAhlLhulshsphttph...s.................tLGYSua.lslsoAllshsss...uLuhtl................ucpp.h...........p	............................lh.lshh..lhhuhl.LshlulF.o.....ssWhs.p..................................thGl.l.Pa.s...tt.s................Whss.suhhhhl...shshhhhhl...lhhhhhhhplhppshst.p...h.+..hhhhhlshhuhlhslhhhl.uhhlhu..ssh..sph.t..h.....................tlGa.ShW.lslsu...sl.lshhsh...hluhhh...........t......................................	1	31	34	96
+6484	PF06656	Tenui_PVC2		Tenuivirus PVC2 protein	Moxon SJ	anon	Pfam-B_15006 (release 10.0)	Family	This family consists of several Tenuivirus PVC2 proteins from Rice grassy stunt virus, Maize stripe virus and Rice hoja blanca virus. The function of this family is unknown.	25.00	25.00	1054.90	1054.70	16.90	16.60	hmmbuild  -o /dev/null HMM SEED	785	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.32	0.70	-6.75	5	33	2009-01-15 18:05:59	2003-07-24 16:25:15	6	1	6	0	0	34	0	784.10	74	94.19	CHANGED	lplSCstsssPC+psphLNGYYIEcGuICYN+AsINLaET..CFoGKYDp+lPVH..FSc...FGGpRYlcCDDEIlscso.LVGFpQscaTSKsLPINscNu-LVSYspuc.cuFhGlVYVEslcYC...spsscscpIlNcusuLph.slCpDGlLhuusSEC-lsVuETEFclPSCussKLPlYDDpIcVCpNssC+NVoCTsSslClsYDRMDFlhRlKNY-CS+oY+YalYllILllIIllChssIsIINILlhLKP...VFWLlKKllaulsGLCHR+PslpcsElDMupVRVV-Ds--GLLlsE-S+APNSNVs-plhpKAR+h-NGLIYIPYILhhLsLlhoous..CpDLVSSLSNIEVCsupsCcasSKlpLTLhNTPQDFCFKopSDVYKIRlspIoV+CLSRPLYYTNSYKRsIu+-DWKCFEG.cCosDsSpSIWDKS-S.LHYDYC.VsDFHlFSYC..PFYH.YNWKRIpYcPTS+LACoV+KCs-sQFEIsGYlo.KNGpVl+ElSGaoSsY-usIloIoLLSYNot+LP+EYVECDuKAYcRsuNDLGSFDKELhGSIQCPT+-DAhpLTsKCpTKlpul.EDpssIpY-EsDGlspLscTtoEPL+sVlVSpsGISLDThDlaPVTLoIpopccIoSIlTS+IShNsTsCcIKGVERKlKKTlI+VcosoKllLSDlLsCcDLAsCSLTFNs-....c+uECaTTSY+ssuoGssIpC+FlYSGDo...IhCKYsVSPl-IsVVSPplDloSF-uVKcSoQNWssFlh-hIRDNPKLTIVASILPIGhlLKTlKu	.VKVPCSARAPPCKLTYELNGYFIENGLICYNRASVNYFET..CYTGNYDYKLPLHPSFSK...FGGHVYLSCDDAILQNVS.LVGIQQTEYTSSPLLITNSNSEKISYSNLK.TGFLGIVYAVETRACIQPDQAKKPEEIINHGVAI..KPSCTDGVLYYINSACEVNVSDQTFSIPSCESVKLPTYDDTIEVCDKGGCQNVTCHPGEICDKYERMDMIMRIKNYQCSHIYRYSLYSIILFFVIVIVFTLITIMNILFFLKP...AFWLLKKVLYSMVGLCHRRPVVDEVSVDMSTVRVVDEAEEGLLVVEDSIAPNTNVSDKVKRKGRKVENGLIFIPYlLMILLLVCSAES..CQDLVSSISNIERCTNNSCDFISKMKLTLLNTPQDFCFKTSTDVYKIRFNSVRVMCLSVPLYYTNSFKRVISREEWKCFEGEGCRTDGTHSIWGESTS.LSFDYC.VTDFHIFSYC..PAYH.YNWKRIEYEPTSSRACTIMKCMDTKFEIVGYIQ.KNGHVLKELGGITSKYDSPLVSISLSNYNSARMPREYAECDGKAYLRTANDLGSFDKELLGNIQCPTKEDAVVLSSKCKTKILSN.EDLPVIRYlERDGVDMLEHVKSEPLKDVLVSSSGISLGTLDLFPVELNLQFKEAITSIITSKISLNGTSCKITGIERKFKKTTVSIESSNKVYLSDILACEGLAVCPMILNNI....KKGTCITTTYYSVTVGSMIKCKFIYSGDT...LMCKYDVSPLEITVISPSLDVSSFEAVKTSTTNWMELLAGIVKDNPKLSLVASIIPIGLILKTIR.S	0	0	0	0
+6485	PF06657	Cep57_MT_bd	DUF1167;	Centrosome microtubule-binding domain of Cep57	Moxon SJ	anon	Pfam-B_9878 (release 9.0)	Domain	This C-terminal region of Cep57 binds, nucleates and bundles microtubules. The N-terminal part, family Cep57_CLD, Pfam:PF14073, is the centrosome localisation domain Cep57 [1].	24.40	24.40	25.10	31.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.41	0.72	-4.03	29	210	2009-01-15 18:05:59	2003-07-24 16:32:35	8	7	119	0	127	209	0	76.60	34	11.72	CHANGED	pcsohpsutsstpuL...upllptLpDEhsHhphchpcLtt.hpplDsohspcpRcpLtpclcpLlcclEtKu-QIhpLhcl	.....................s.psSpuss-sL...u-lLpsLQDEhspMsh..-HppL...h+plpc...o..spch+csLcpELEpLlc+MEtKucQIsKL++h.....	0	27	44	77
+6486	PF06658	DUF1168		Protein of unknown function (DUF1168)	Moxon SJ	anon	Pfam-B_9807 (release 9.0)	Family	This family consists of several hypothetical eukaryotic proteins of unknown function. 	22.10	22.10	24.30	24.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.20	0.71	-4.67	36	257	2009-01-15 18:05:59	2003-07-24 16:56:40	7	5	228	0	194	254	3	141.50	35	69.22	CHANGED	Pc+thtlPctscphs.t.....ssPEhVpNV.GSSAGAGSGEFHVY+ptRRREYpRlchh-cpsc+-ppscpappKpcEpcctsEEKTtK+RtKRpK+KpKpppt+ptcpts................ttppspppspssssssccs...........t...tsthtsc	...............................p+.h.lPpt.pp.hs.p......ssPEhVpNV.GSSAGAGSGEFHVYRphRRREYpR.chM-ppsc+cctcpEFpp+hccpcptsEE+TsKpRtKRpK+Kp++ttt+ptptpp..............................tttt.tttttpt.ppttpttptt.......................ssttt.t...................................................................................	0	68	105	155
+6489	PF06661	VirE3		VirE3	Vella Briffa B	anon	Pfam-B_16550 (release 10.0)	Family	This family represents a conserved region within Agrobacterium tumefaciens VirE3. Agrobacterium tumefaciens (a plant pathogen) has a tumour-inducing (Ti) plasmid of which part, the transfer (T)-region, is transferred to plant cells during the infection process. Vir proteins mediate the processing of the T-region and the transfer of a single-stranded (ss) DNA copy of this region, the T-strand, into the recipient cells. VirE3 is a translocated effector protein, but its specific role has not been established [1].	19.50	19.50	22.90	24.00	18.50	17.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.95	0.70	-5.31	4	15	2009-01-15 18:05:59	2003-07-25 11:30:11	6	1	9	0	3	14	0	270.50	55	49.60	CHANGED	psRLEsP.+K+KYsuDhpllsKLDsGFRGEIuYKlhGNcpLRlDpspELT+E+Gll+KTKpVLKRsssTGplYLuhHERKoWsSVooHpYupDGoLRtKHVKYKDGRFEE+WERDEsGsLlRTRYhNRGRLssthh+PlSEEhuAPYcSGs-pRLYRcLTRQsGS++ETFERDDKGNLELlupKRhGFS+pohKutDRpTSpTpIRKLGGAFSKSYRSLLDKEGNElGRDllSHRRLaNKRSAlYD-uTGQLKShKHTFGKIYKuEupYLsAclKcVSKKILGVTVtR+LssLSEcEhpAp+LRshEsutH+QAWQc	...........ARLEsPppK+KYsuDMpllDKL-sGFRGEIuYKhhGNcpLRlDsspELT+E+Gll+KT+cVLK.RsspTGsVYLuhaE+KoWtSV..oSH.YupDGoLRsKHVKYKDGRFEEKWERDEsGtLhRTpYhNR.sRL....FpPlSEclusPYcSGs-NRLaRcLTRppGS+pETFERD-KGNLELIGpKRhGFS+sSsKu.DRpTSpTpIRKLGGAFSKSYRSLLDpEGNElGRDI.SHRRLhNKRSAlYD-uoGQLpSsKHTFGKIYKSEotYLsAclKcVSKKILGVTVtR+LssLScpEh-AQ+LRstEustH+pAWQc.........	1	0	2	2
+6490	PF06662	C5-epim_C	C5-epim_C-term; 	D-glucuronyl C5-epimerase C-terminus	Vella Briffa B	anon	Pfam-B_16571 (release 10.0)	Family	This family represents the C-terminus of D-glucuronyl C5-epimerase (EC:5.1.3.-). Glucuronyl C5-epimerases catalyse the conversion of D-glucuronic acid (GlcUA) to L-iduronic acid (IdceA) units during the biosynthesis of glycosaminoglycans [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.19	0.71	-5.01	18	182	2012-10-03 02:33:51	2003-07-25 13:05:58	8	7	150	0	112	191	17	180.00	42	36.94	CHANGED	Q-.ppGuWshshshphhps.t..LssGWhSAMuQGpAlSlLsRAYphTp.DpcYLsuAt+Als.aplsspcGGlhsshhsh......hsWYEEYs.....ToPsoaVLNGFIaoLlGLYDhs.............stphsscApplFppGlcSLKthLshaDs.GshohYDLpahs.hspsPsluthpYHshHlp.LphLhsIs.s..-.happhhc+Wpu	................................D.ppGGWsh.VpRplh.psht..LpsGWhSAMAQG.........pAlSsLs.RAYhhTp.DcpYLpuAh+Ahtsa+hs...upp..sGVhuh.Fhsp.............asWYEEYP.....TsPsSaVLNGFhYSLlGLYDLpp..........sstphuc-A.ppLappGhcSLKthL.PLYDT..G....SsohYD...LRHhh......lshuPNlAphcYHshHlpQL.hL.sls.p...s.hh..tphsc+Wp.........................................	1	36	52	86
+6491	PF06663	DUF1170		Protein of unknown function (DUF1170)	Vella Briffa B	anon	Pfam-B_16582 (release 10.0)	Family	This family represents a conserved region of unknown function within MAGUIN, a neuronal membrane-associated guanylate kinase-interacting protein. This region is situated between the Pfam:PF00595 and Pfam:PF00169 domains [1]. All family members also contain an N-terminal Pfam:PF00536 domain.	21.90	21.90	23.60	24.40	17.10	16.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.12	0.71	-4.37	6	166	2009-01-15 18:05:59	2003-07-25 15:36:33	8	13	39	0	95	132	0	172.60	47	23.89	CHANGED	huss..oK+-ssAlpDLYIPPPPutPYoPRDEpGshss-sts+.ph.shsVsKGSESPNSFLDQEsR+R.FslsEpDplsashph-psh.hss+hR-sTPTYG+LRPISMPsEhNWhu-s-D.uKh+RpuR.pEsSLhRYhS....s-+Is..sEE.......ahhuRsusccphhR............................u++KScpusosu...chSLLsSh	............................h.sossK+-psAl.DLYIPPPPu..PY......PR.DEpGshsspshpp..ph.shPstKGSESPNSFLDQE...R+R.Fsl.s-.pDpl..sYph-psh..stth.REpTPoY...G.K.R..PlSMPs-hNWhGth-s.s+.+t.cuR...t...EsuLhRYhS....NE+Is..tEE.......a.hhpRsspccphh+................................................sKKKutpuso.o...c.SLLsS..............................................................................................................	0	2	8	50
+6492	PF06664	MIG-14_Wnt-bd	DUF1171; MIG-14_Ce; 	Wnt-binding factor required for Wnt secretion	Vella Briffa B, Pollington JE	anon	Pfam-B_16593 (release 10.0)	Family	MIG-14 is a Wnt-binding factor. Newly synthesised EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion [1].	20.90	20.90	21.10	21.10	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.80	0.70	-5.59	15	334	2009-09-13 15:31:17	2003-07-25 16:08:38	7	4	113	0	203	313	0	260.00	30	52.85	CHANGED	tpC-plslhclGhLcaspYllslphss.p.h.............plp.slphphhphNssFTpl.lhh+hlFhlhohlhhshFsppl+plshpsWhlEQKhhshLhslLllhNsPhahhslhhsssahllLsslhQulFhshLhhFWLlhhcplhl...pspRcsl+s.YhsKllhlsllhlshllhshhp+sppLcDPhaShhssshshpshhsahhlsslh...YlLaLlahIl+sasplcspth..h.....................................................Ra+alhlhslhshshsllhhhhs...........hsph.thtpo..SApFhshYulhNlYlasltalYuPScp	.......................................pCs.l.hhclG.lsap.Yhlslph.s.pph...................plp..slp...h..h...hhp..NsuFop.l.lhh+hhhhsh.s.hllh.....sh.....a..h.+..pl..............p.hhs.h.s...hhlE..Khh.hLh.hhhhhN.....Ph..h.ohhh....s.....h.h.....hh..h.sslhQuhF.hshLL.FWl.hhht.....thhh............ptp+.p.plp.......h..Yh......p.....lhhlshh.hshhhhshh....p....pss.p.LpsP.hYphhss.shsh.p.hh.....hhFhhlsshh......Yhla..Lhahlhpshpplpth.....l............................................................................RhKFLhhhohh..shsholhhhhhp..h.th.....................t..hs.......h.sh..s........uu.FhuhYGhhNhYlaslhhlYuPut.....................................................	0	98	111	160
+6494	PF06666	DUF1173		Protein of unknown function (DUF1173)	Vella Briffa B	anon	Pfam-B_16904 (release 10.0)	Family	This family contains a group of hypothetical bacterial proteins that contain three conserved cysteine residues towards the N-terminal. The function of these proteins is unknown.	25.00	25.00	31.70	30.70	18.30	23.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.20	0.70	-5.63	17	141	2009-01-15 18:05:59	2003-07-28 10:16:29	6	2	109	0	50	143	15	350.90	28	91.03	CHANGED	patlsspshst........sssplQshLspAappttR...PhCLC..p..tssltMYlA+hs.sp.allKRMPtoGtcHss..uCsSYEss.phSGLGtlhGsAlp-.scsGpssL+lsFuLo+tssRss......Psupsst..ss.slcsssp+loLRuLLHaLW-cAtLscWsPshsGKRsWuhVRphLLpAAcphps+uhsLu-hLaVPEsFps-pKstlupR...RpstLushth..t.Gpp+hhlllGElKphssuR....Gc+lsl+Hh.PshP..hhlcschacRlt+pFssELchWcuspst.....+LlsIAphs....hsssGhspl--luLMhVoEpWIPhEostEt.LlctLssp+RRFlKsLRashssstPhssslLhDspspssuhalVsutsspca..ctslcchl.scsthss..WhWcsup	....................................tt.s.th.pthLtpAa.t..ppt.p......shChC.....p..pss.....h.hhl..tph.......s...sp...ahltRhPsoGtp...H..ss..sCs.ac......sssch.SGhu..........t.hhusslpt.spsGphsl+LshuLscts.spts............stststt....t..ss.pss..tpphoLhulLchLWppAtLspWtPshs.G...+R.shsh.V+ttLlpAApphtsp.tt....s.LschLal.t.aps....pp+ptlttc............ptthluphth....ts.pchhlllu.lpchsss+h.....upp...lsl+ph.ss...hs........hhh..spshac+lp+RFstE...LthWpssp............+llslut.hs............hstsuhspltcluLMhVo.cp.WIPh-osaEhhlhcpLstppRpFlKsLRashsts.........tshsshhLhDst..t......s.sshh.V.u.hs.s..pa...cpthcphh...spphhss..W.hWcst.t..................	0	8	21	39
+6495	PF06667	PspB		Phage shock protein B	Moxon SJ	anon	Pfam-B_21806 (release 10.0)	Family	This family consists of several bacterial phage shock protein B (PspB) sequences. The phage shock protein (psp) operon is induced in response to heat, ethanol, osmotic shock and infection by filamentous bacteriophages [1]. Expression of the operon requires the alternative sigma factor sigma54 and the transcriptional activator PspF. In addition, PspA plays a negative regulatory role, and the integral-membrane proteins PspB and PspC play a positive one [2].	24.30	24.30	24.40	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.59	0.72	-4.04	36	768	2009-01-15 18:05:59	2003-07-28 11:43:46	7	3	748	0	106	251	47	74.20	63	97.85	CHANGED	Ms...h.hlhsPlllFhlhVAPlWLlLHY+oKppsupGLopc......-pppLppLhppA-+Mp-RlpTLEpILDAEsPsWRp+	.....................................MS..ALFLAIPLTIFVLFVLPIWLWLHYS...N.R.u.s.p...up.L..S.Qu......E..Q..QRLtQLsD-AcRMRE..RIQALEsIL.DAEHPNWR-..............	1	20	44	74
+6496	PF06668	ITI_HC_C	ITI_HC_C-term; 	Inter-alpha-trypsin inhibitor heavy chain C-terminus	Vella Briffa B	anon	Pfam-B_16674 (release 10.0)	Family	This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix [1]. All family members contain the Pfam:PF00092 domain.	21.50	21.50	22.50	21.50	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.07	0.71	-4.88	29	404	2009-01-15 18:05:59	2003-07-28 12:08:42	7	13	48	0	193	292	0	177.50	33	20.30	CHANGED	soGlsVNGQlIGsct..s.tp+pcTYFupluIshpp.chp.lElTspplsl.cuppp.shsWp-osslspsulplols+ppslsVolsssloFsllLH.phhKtpPhppDaLGFYlhsoc+hSupsHGLLGQFhpt.-hclhchhsGsDspK...............s-AohpVKucplsVTRthpKDYppc....GppVsCWFV+N	.........................................................oGlpVNGpllGs.t....tppppTYFuplslhhpp........c..hp...lElo..scp.Isl....p.G....spp..shsWpcosh.l..t.p.....ss...lplo...ls.....+pps..lsl...olscslsFsl.llH.phh+.p............sh..........pp.-aLGhYlhso.cphSspsHGLL.G...........Q..........F...hpt.chclhs..sutssp+...............scA..shhVKupplsVT......Rt.p+DYpps.....Gp..plsCWFl+N........................................	0	19	28	87
+6497	PF06669	X_fast-SP_rel		Xylella fastidiosa surface protein related	Moxon SJ	anon	Pfam-B_21796 (release 10.0)	Repeat	This family consists of several Xylella fastidiosa surface protein specific repeats which are found in found in conjunction with Pfam:PF05662, Pfam:PF05658 and Pfam:PF03895.	22.60	22.60	23.60	22.80	21.70	22.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.36	0.72	-4.04	2	73	2009-01-15 18:05:59	2003-07-28 12:12:23	6	31	27	0	9	81	0	68.30	60	6.35	CHANGED	NAVQsQASQPVTFoGNEGuVKRoLGQuVVISGESSTAGTYSGGNLKSVVDEAAGtIHLQLADSPKFGNVl	.........NAVQsQASQPVTFoGNEG.o.VKRoLGQuVVISGESST.A.G.TYSGGNLKSVVDEAAGuIHLQLADSPKFGNVl................	0	3	8	8
+6498	PF06670	Etmic-2		Microneme protein Etmic-2	Moxon SJ	anon	Pfam-B_22009 (release 10.0)	Family	This family consists of several Microneme protein Etmic-2 sequences from Eimeria tenella. Etmic-2 is a 50 kDa acidic protein, which is found within the microneme organelles of Eimeria tenella sporozoites and merozoites [1].	21.90	21.90	238.40	64.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.40	0.70	-5.75	2	8	2009-01-15 18:05:59	2003-07-28 12:17:37	6	2	2	0	0	10	0	302.50	73	99.96	CHANGED	MARALSLVALGLLFSLPPSSAVRTRVPGEDSFSPESGVLSGTDAPERRP..............lVPGLsEGNCGRLTVRNGLSVDETIKVTSAGWTKSERDFIVSLVADETRKVVQLRESEGASGASGPGPAPAEKPPSGQGSAEEAPKGEGGQEKPSVPLIAVRIHGSGGDKGESAPQSAVLLYGNDESEPTEVPLETAAGPTTPLMVLITQQNPKEVEVRVLAWIST.......................DATTGKGSWKENSVVVGSSLSGRDLTVNLSDCGPSSLRVYGSASADLVTVKEGMCEADDPELIALTRPHTSAASPLPAEEGDVAQDAQQSAGAQQEAEsQEVGEPQQEAAAAEQGSSAAESDTQQSS	...MARALSLVALGLLFSLPPSSAVRTRVPGEDSFSPESGVLSGTDAPERRP..............lVPGLVEGNCGRLTVRNGLSVDETIKVTSAGWTKSERDFIVSLVADETRKVVQLRESEGASGASGPGPAPAEKPPSGQGSAEEAPKGEGG.QEKPSVPLIAVRIHGSGGDKGESAPQSAVLLYGNDESEPTEVPLETAAGPTTPLMVLITQQNPKEVEVRVLAWIST.......................DATTGKGSWKENSVVVGSSLSGRDLTVNLSDCGPSSLRVYGSASADLVTVKEGMCEADDPELIALTRPHTSAASPLPAEEGDVAQDAQQSAGAQQEAEAQEVGEPQQEAsAAEQGSSAAESDTQQSS.........	0	0	0	0
+6499	PF06671	DUF1174		Repeat of unknown function (DUF1174)	Moxon SJ	anon	Pfam-B_22180 (release 10.0)	Repeat	This family consists of a number of Caenorhabditis elegans specific repeats of around 36 residues in length which are found in two hypothetical proteins. This family is found in conjunction with Pfam:PF00024.	19.70	10.10	220.50	10.10	15.30	10.00	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.33	0.72	-4.31	36	528	2009-01-15 18:05:59	2003-07-28 12:22:07	6	7	5	0	394	512	0	23.10	67	46.28	CHANGED	SGEETTTuAVTEASG...EETTTu...AVTEu	.....sctsTs..uA.......VTEASG...EE.oTTu...AsTEu........	0	67	130	394
+6500	PF06672	DUF1175		Protein of unknown function (DUF1175)	Moxon SJ	anon	Pfam-B_21722 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 210 residues in length. The function of this family is unknown.	20.60	20.60	20.60	20.60	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.42	0.70	-5.00	13	358	2012-10-10 12:56:15	2003-07-28 13:11:22	6	3	342	0	32	141	11	193.80	79	93.81	CHANGED	.hhhthpspssstcucs...thLssppStsFRsWFVRIAppQlRps.ss+W..cp+DCAGLVRFAspEAL+tHDucWhcssGhs........s+Yh.PchsL.usphhhtpphp.....pssGp..husassAhsLlppNo+Flu+D...lspApPGDL.lFFcQtDsp...HLMIahGc.........allYHTGshsc.s-stlRsVolppLhpa.DscWpPhssNPsFlGlYRhsFLs	............................tlLhLlsalsCsV.............AHS...EMLNVEQSGLFRAWFVRIAQEQLRQG.PSPRW..YQQDCAGLVRFAANEs.LKVHDSKWLKSNGhS..................SQYLPPEMTLTPpQRQLAQNWN.....QGNGK..TGPYVTAINLIQYNSQFIGQD...INQALPGDM.IFFD.QGDAQ....HL.MVWMGR.........YVIYHTGS........A...TK.T..........DNGM.RAVSLQQLMTWKDTRWIPNDSNPNFIGIYRLNFL.A......................	0	10	15	25
+6501	PF06673	L_lactis_ph-MCP		Lactococcus lactis bacteriophage major capsid protein	Moxon SJ	anon	Pfam-B_21754 (release 10.0)	Family	This family consists of several Lactococcus lactis bacteriophage major capsid proteins.	19.40	19.40	20.10	19.60	18.00	18.80	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.11	0.70	-5.67	2	7	2012-10-03 06:22:39	2003-07-28 13:15:30	6	1	7	0	0	9	0	346.70	95	81.31	CHANGED	MGsNETQEhMKQAIEAGVKVRELEsKVEELNKEREELKKEREAsIPSEKPpDsERKFMRELGsKMsEMPEQGFLREFANuusLNVVNSLGSITSKYARKSGIYDGAMKARFQGLTLAEDGVDDTFIpGTFKAGTDKNKuQTAoKRSLRPQMAEAYLQMDKATVRGVNDSGALSEYVMSEMVNRVIQKVEaNMILGSsDGSNGFYGLKTATDGWTKQIEYTDLF-GITDAVAECSISDAITIVMSPQTFAELRKAKGTDGHSRFNELATKEQIAQSFGAVNLETRVWMPKDEVAVYNHDEYVLIGDLNVENYNDFDLRYNVEQWLSETLVGGSIRGKNRSAYLpKKuS	................................MGANETQEIMKQAIEAGVKVRELEAKVEELNKEREELKK.EREASIPSEKPQDsERKFMRELGDKMsEMPEQGFLREFANuuDLNVVNS..LGSITSKYARKSGIYDGAMKARFQGLTLAEDGVDDTFIpGT.FKAGTDKNKuQ.TATKRSLRPQMAEAYLQ..MDKATVRG..VNDSG.ALSEYVMSEMVNRVIQKVEYNMILGSADGSNGFYGLKTATDGWTKQIEYTDLFEGITD..AVAECSISDAITIVMSPQTFAELRKhKGoDGHuRFNELATKEQIAQSFGAVNLETRVWMPKDEVAVYNHDEYVLIGDLNhENYNDFDLRYNVEQWLSETLVGGSIRGKNRSAYLKKKuS..........	0	0	0	0
+6502	PF06674	DUF1176		Protein of unknown function (DUF1176)	Moxon SJ	anon	Pfam-B_21791 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 340 residues in length. Members of this family contain six highly conserved cysteine residues. The function of this family is unknown.	34.80	34.80	35.00	35.10	34.50	34.70	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.28	0.70	-5.33	26	714	2009-09-11 20:41:29	2003-07-28 13:20:13	6	5	643	0	80	389	14	321.60	47	92.18	CHANGED	lshsshsss.....shthpacDWpVsCDNspsCpAsuhsscp.s.........lslhlpRpAGssssl.phclph.up.tts.........stthpLhlDGcshuhhssphptt.t..................phsssplsAlLpslppupplslt..sust.......hplShsGhsAuLLhhD-hQuRlGTssAllcK..GspPssuVssAsshPsl..ssssssst.....shstpptpthtpssh..........hpsspsp..tttssh..pst................lstLssspsLlhhsC.hsGAYN.ps.shWllscp.............tshpsphlshp..................sssas..suplsshtKG...RGluD.CGstspWha....DGpp..FhLsptsppupCcshtuus.....sW.hsahsp	............................................................hs..hphlWAA......PuQ+sFuDWQVTCNNQNFCVARNsG-HpG..........LVMTLSRSAGA+TDA.lLRI-t...GGltsPcAp.....cutIAPRLL.LDGcPLu.h..sus+W+loPahLh...............TsDsATITAFLQhIQ-.up.AITL+..sGsQ........TlSLuGLKAALLFIDAQQKRVGSETAWI+K..GsEPPLSVPPAPALKpV..Al.lNPTPs.....PLS.E.ERsDLLDYus............WRhNGhc..CS..LDPLRREsp.................VoALTDDKA..LhhlsC..EAG...AYN.TIDLAWlVSRK.............Ksh.so.RsVRLRL.......PFssutEos-........hELMNAsFDEKoRE..L..V..TLAKG...RGLuD.CGIQsRWRa....DGpR....F.RLVRYAsEPoCDsWHGPD....AWPTLWIT.R.......................................	0	9	26	58
+6503	PF06675	DUF1177		Protein of unknown function (DUF1177)	Moxon SJ	anon	Pfam-B_21818 (release 10.0)	Family	This family consists of several hypothetical archaeal and and bacterial proteins of around 300 residues in length. The function of this family is unknown.	25.00	25.00	63.10	62.90	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.76	0.70	-5.81	22	133	2009-01-15 18:05:59	2003-07-28 13:23:24	6	2	116	0	50	126	4	262.00	54	88.23	CHANGED	clpplss......pGsTDFl+lhlsGptG+..GGsAPTlGIlGRLGGIGARPpphGLVSDADGAlsAlAsALKLhcMpc+GDhLsGDVllsTHICssAsshPHcPVsFMsSPVshspMN+pEVcPph-AILSIDTTKGNRllpa+GFAIoPTlKEGYIL+lS--LlcIhphsTG+.shshPlTpQDITPYsNslYHlNSIlQPs.lsTsuPVVGVAITucssVPGsuTGAoc.sDl-pAuRFslEVAKtaspGpscFYDppEatcLpphYGshspLQphGcp	...................p.hpplpup.....pGsTDFl+lhIPGppG+.tGGsAPTLGIlGRLGGIGARPphlGhVSDuDGAlsAlAsAhKLhcMpp+GDhLsGDVllsTHICPcAPTpPHcPVsFMsSPl-htsMNcpEVs.sphDAILSlDTTKGNRllN++GaAlSPTVK-GYIL+lS--LLclhphsTGc.shsaPlTpQDITPYGNGlaHlNSIlQPu.sATsAPVVGVAITopssVPGCuTGAoH.sDlstAsRFslElAKtFGpGpspFYDppEappLhphYGshs+LQshGp.t....	0	12	25	39
+6504	PF06676	DUF1178		Protein of unknown function (DUF1178)	Moxon SJ	anon	Pfam-B_21872 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.	26.50	26.50	26.90	30.90	24.20	26.40	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.99	0.71	-4.00	79	438	2009-09-13 03:22:43	2003-07-28 13:25:38	6	3	420	0	154	372	1244	143.00	40	98.30	CHANGED	MIhasLpCs.psHpFEuWFtSussF-sQtspGLVsCPhCGSspVpKslMAPplssuppt.....................tssPssssssts............................pttltclpccltpso-.VGccFAcEARchHh.GEsscRsIaGcAos-EActLlEEGIsVhPL..P.....hsscpp...s	...........MIhasLpCs.pu.HpFEGWFtSus-F-pQtpptLVsCPsCGospVpKtlMAPplstupsptt...............................................s.sh.t.t....................................................ttl.tthtpht+pVhpss-.VG-+FA-EAR+IHa.GE.s..tRuIhGpAos-EscsLhEEGI-lhPL..P...h.st...t....................	0	37	91	118
+6505	PF06677	Auto_anti-p27		Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)	Moxon SJ	anon	Pfam-B_21881 (release 10.0)	Family	This family consists of several Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) sequences. It is thought that the potential association of anti-p27 with anti-centromere antibodies suggests that autoantigen p27 might play a role in mitosis [1].	23.20	23.20	23.20	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.23	0.72	-4.19	14	282	2012-10-03 10:42:43	2003-07-28 13:32:39	7	6	238	0	193	271	18	40.90	37	20.80	CHANGED	cl.cphuchLhpGApMLscpCspC.GsPLFc..KsGclaCPsCp	....t.h.phhuchLLpGhpMLscpCs..p..C....G..sPLh.......c.......+.p.G.c.h....h...CssCp.......	0	83	124	160
+6506	PF06678	DUF1179		Protein of unknown function (DUF1179)	Moxon SJ	anon	Pfam-B_21899 (release 10.0)	Family	This family consists of several hypothetical Caenorhabditis elegans proteins of around 106 residues in length. The function of the family is unknown.	25.00	25.00	27.10	26.00	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.54	0.72	-3.72	4	16	2009-09-10 23:27:31	2003-07-28 13:37:01	6	1	4	0	15	15	0	97.00	34	92.33	CHANGED	MaSFshIhcsIsL.FGs.FLLlssllpCp..SKKKF+sDt+scLV.....uPhppssscpspt.tsPsuQsPPs+hPhEpospht.....-DTLANV+SlPPcpp.t.ct.chKpKp	.......................h.hlhpplhL.....hlLhhsll.pCp..pKKKFcsDt+ApLV.....sPss.sssc....ssps.psPsuQ.........sPPs+pPlEposp.t.....EDTLANV+SlPPEKS...pp.chKh..t.......	0	7	7	15
+6507	PF06679	DUF1180		Protein of unknown function (DUF1180)	Moxon SJ	anon	Pfam-B_21907 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins of around 190 residues in length. The function of this family is unknown.	24.80	24.80	24.80	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.14	0.71	-4.35	7	117	2009-01-15 18:05:59	2003-07-28 13:39:38	7	1	66	0	80	126	0	144.30	30	90.58	CHANGED	M......uhhs.h.ssshLLhLLs.L...sulhpcAssAss.....pPtspp.s..PPuPosu.......................Psuh..hts.tGssussSsGusLss..sss..spPhhpRALhVhsshSAhlllYFllRshRhR+Rp+KTRKYGVlcTshtshEhsPL.EpDDEDDD.TlFDhp..RR	.......................................................................................................h.t......................................................................................ssst.......................................sst..................tstt...s.p...s.s.s.ssslhsp.s..s.......h......-h...s.h.hp...pul..hVlhuhouhlllhhll....R.shRh+....+.+t.......+K..oR........+YGllsss...-shEhs..PL...-pD...DE--DpTlFDsph........................................................	0	15	19	43
+6508	PF06680	DUF1181		Protein of unknown function (DUF1181)	Moxon SJ	anon	Pfam-B_21912 (release 10.0)	Family	This family consists of several hypothetical proteins of around 120 residues in length which are found specifically in Trypanosoma brucei. The function of this family is unknown.	25.00	25.00	167.70	167.00	17.70	16.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.69	0.71	-4.43	2	14	2009-01-15 18:05:59	2003-07-28 13:41:54	6	1	3	0	10	14	0	112.40	87	82.70	CHANGED	MFQLVSssEVNKAYVSYPGGVSMCLRFPFCHCVWAHAMTLIEISGHYHRWVARGtSEDWDYSNSFVVVCsVLLENIAssEREGKCHLTFHAATSMH+sYMLVALpGKsVKAKVSFRF+EV	....MFQLVSsAEVNKAaVSYPGGVSMCLRFPFCHCVWAHAMTLIEISGHYH+WVARGESEDWDYSNSFVVVCsVLLENIAsNEREGKCHLTFHAATSMH+sYMLVALpGKVVKAKVSFRFKEV.	0	0	10	10
+6509	PF06681	DUF1182		Protein of unknown function (DUF1182)	Moxon SJ	anon	Pfam-B_21992 (release 10.0)	Family	This family consists of several hypothetical proteins of around 360 residues in length and seems to be specific to Caenorhabditis elegans. The function of this family is unknown.	25.00	25.00	26.60	26.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.66	0.70	-5.14	2	21	2012-10-03 04:04:29	2003-07-28 13:44:35	8	1	6	0	20	18	0	203.70	36	63.80	CHANGED	h.N.......................NhsLsslTsTPhTYRDRIhhEF.lpuTshlFshhLsIFhhhR.tlhhohKsTIhFVTLGoFlLslPLhhhQhahVh.L.uhhpPhYTlhVCohlKshsSSTTSshQVLPhAVulYRYhhVVhpt+.ssWFVlsVH.IlohIFhlhAhLNaPhGE.ppND.ChsLRFSpuMEhVRI..TLhhNhhAlhlNhsIhpFVK+a-	.................h...................................s.ThTshpaRDRIhhEahlpssshlhshhLsIF.lhh+.plhhphK..............sTIhFVTlGoFlLslPLhlhQsahVhhL.ss+pPpY.o.lhlCohlKshsSuTT.SstQVLPhs................VulYRYhlVVhct+hs.saFVlsVHsllohlFhlhAhLNaPhG-.ppNDhChhLRFSpuMEhVRI......TLhhN...hhAlllNh..sIhpFVK+a-......................................................................	0	9	10	20
+6510	PF06682	DUF1183		Protein of unknown function (DUF1183)	Moxon SJ	anon	Pfam-B_22014 (release 10.0)	Family	This family consists of several eukaryotic proteins of around 360 residues in length. The function of this family is unknown.	30.80	30.50	40.90	36.50	29.70	30.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.27	0.70	-4.82	14	202	2009-01-15 18:05:59	2003-07-28 13:50:05	7	6	157	0	140	197	2	268.30	35	85.91	CHANGED	h.hLlaLLlh.......stssps..hsspc.....tlLLpcVpsLTLhtsRhTouRRsuPlPQLKClGGSu.tCptapPcV..lQCtNpG..aDG.DVQWpCcA.sLspsa+hGps-VsCEGYcts-DtYlL+GSCGlEYpLpLTEtGccKhspth.pph.sthps.........................ps.ppt.t.....sshlhhlhhlhllAahlYthhhps.t.pttshsspsGhss...................tsss.tsts..uPPPPh.p........sshsss.s.sstssss.u...........tstts......tPGFW..TGhusGu..hhGYLhGppps..........pphstshss...........ta....ss.t..sptoupussusssou...T+ouSGaGuT+RR	.......................h........................t...........ts.....tlLLpcVpsLTLp.t.s.+hTouRRssslPQLpCl........Gs..ot.hC...s..h...apP.cV..hpCpNpG...............aDs...DVQWpCpA......s......Ls...tpa+h..G..p.ssVsCEGYcts-DsYlL+GSCGlEYp.......LthTchGt.p+htp.h.t.t.th........................................................stt.............hshlhhl.hhlhslsahl...Yphhhts..t.t..........s.ttsshst.......................................hhtt..s..s..s..sPP..PPh............................t.ss.......st.............................tt.ts......tPGFW..oGhusGu....hhGYhhGpppt.................................t...s..s...............h...........st.....................s..s......s.t..ustsss.....p+puoGaGuTpRR......................................................................	0	55	76	110
+6511	PF06683	DUF1184		Protein of unknown function (DUF1184)	Vella Briffa B	anon	Pfam-B_16725 (release 10.0)	Family	This family contains a number of hypothetical proteins of unknown function from Arabidopsis thaliana.	25.00	25.00	26.90	39.90	22.70	23.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.26	0.71	-4.67	4	36	2009-01-15 18:05:59	2003-07-28 14:53:55	6	2	2	0	29	36	0	122.20	37	85.12	CHANGED	R..pNK+.LppSRYSPY.....luThcp........EpQKEEAIRLGVELSLFVAEAMFLLSDsL.................................aVhETYIKPKNGVY..................FshGlt.LspIV.IL.....pssplVKspsFc+hNQELKKLEE+LRSsK-sSEANGFsREtI+SsILpLWKSLFEso..hh.s.KshsLEhF	................................................................................pp.K-EslpLGV-LSlalAEuMhlLsDsl.........................................................................................................h.thhpp..hppl-pplts.p.h.......R-.hc.ph..hWcp.h..................................................	0	9	9	9
+6512	PF06684	AA_synth	DUF1185;	Amino acid synthesis	Moxon SJ, Eberhardt R	anon	Pfam-B_22398 (release 10.0)	Family	This family of proteins is structurally similar to proteins with the Bacillus chorismate mutase-like (BCM-like) fold. This structure, combined with its genomic context, suggest that it has a role in amino acid synthesis [1].	20.00	20.00	24.00	35.60	19.80	17.10	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.00	0.71	-4.91	55	331	2009-01-15 18:05:59	2003-07-28 15:01:51	6	3	227	4	131	326	890	173.60	46	89.66	CHANGED	IRKhlshlE-hht.EGGtss......spPl+psussAVlc.NPaAGR.aVEDLpP.lhchut.LGthLspcllssLGs.scplEuYGKuAlVGssGElEHu.ALhHs.hhGtshR-sl...............................ssupullPuop+hGusGstlslPltHpssualRSHFsohchslsDAPpsDElllsLuhosGGRsHs......RlG	......................IRKhlshlE-ohh.EGG.+ss......spP.l.+hsussAVl+.NPaAG+...aVEDLpP.lhshus.LGphLsccllsslGs.uctlEuYGKAAlVGhsGElEHAuAllHs.+.....hGsthRcAl................................s...uKuhls.sspRGusGsslplPlhaKssthhRSHa.olphplsDAPtsDEIlVslususGGRsHsRlG..................	0	20	56	86
+6513	PF06685	DUF1186		Protein of unknown function (DUF1186)	Moxon SJ	anon	Pfam-B_22662 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 250 residues in length and is found in several Chlamydia and Anabaena species. The function of this family is unknown.	19.80	19.80	19.90	20.10	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.33	0.70	-5.21	7	84	2009-01-15 18:05:59	2003-07-28 15:06:29	6	3	79	0	27	61	0	224.90	33	79.09	CHANGED	M..ptll.ph.h.pthh.c.tlcthl.p+pthhP.Ll.hLcph.pph.pllsctsa.hHlYAhaLLAQFREppAaPLIl+hhShst-..lhhclsGDllTEDLuRILASVssGclphIppLIEspsls.YVRuAAIpuLlsLVuptplSREplIpYFtpLhpt+Lc+csSa..lWsSLVsssssLhPtELh.pIp+AapssLl-shFIshEDVEp.lshpp.-psLpcLhps..apLIpDslt-hEpWhp.....shEs	..................................hppllppLhh.pp.shlPc-AlctAl..pppplsP.LLplL-cAhcc...ss....-lhs-ssh.....psh...l.aAhaLLAQF.REoRAhPLll+Lh.uhpp-...h.cslhG.DslTEDLu+ILASVs-.-hshlpcL...I-ssplssYV+sAAluuLstLlshpplsR-pslpaatpLl...shtL.ccp..sh......shssLl.s....shssLhstELh..IpcsFp...tsLl..-...h.l.sh.........-cV.p.ht.p...-t.ht.h..t......lp.................s..................................................................................................	1	8	18	21
+6514	PF06686	SpoIIIAC		Stage III sporulation protein AC/AD protein family	Moxon SJ, TIGRFAMs, Coggill P, Bateman A	anon	Pfam-B_22771 (release 10.0), TIGRFAMs	Family	This family consists of several bacterial stage III sporulation protein AC (SpoIIIAC) and SpoIIIAD sequences. The exact function of this family is unknown.  SpoIIIAD is the an uncharacterised protein which is part of the spoIIIA operon that acts at sporulation stage III as part of a cascade of events leading to endospore formation. The operon is regulated by sigmaG [1].	21.00	21.00	21.20	21.50	19.00	20.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.60	0.72	-4.17	87	1045	2009-01-15 18:05:59	2003-07-28 15:12:29	6	3	398	0	251	634	10	57.50	29	83.45	CHANGED	hIhKIsGlullsthlstllKcus.sphAhhlslsutllllhhslshlsslhpslpplh	....hlhKIsGluhlsthhsplhK..csG.ppshAthlpLsGtllILhhslshlsslhcslpslh.......................	0	135	210	225
+6515	PF06687	SUR7		SUR7/PalI family	Moxon SJ, Coggill PC, Bateman A	anon	Pfam-B_22775 (release 10.0)	Family	This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homologue of human endophilin, suggesting a function for both in endocytosis [1,2]. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane.  Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localise with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation [2]. This family also includes PalI which is part of a pH signal transduction cascade.  Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH [4].	24.10	24.10	24.10	24.30	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.57	0.70	-4.77	99	777	2012-10-03 00:20:40	2003-07-28 15:22:48	7	5	142	0	570	851	0	230.30	18	62.52	CHANGED	hthlshll...hhsuhlhhlhssluss..t.........lpphahhph.sstth...................................................................................................................................t........................hpauhaGaCts.......................................t.pstpCop.spsuashssh..p.ht.p......................................thslPsshps......t......h...hphhhhhhlluhh...hohlshlh.hl.h...........................................uhhtt............................................................hhshlshlhshluh..lhshlusslssshalh..hht.hpp...........husphhshsWhslussllshlh	.......................................................................................................................................................h..hhshhhhhsuhlhhl.....l.shluss......s.......lpshhhhph..shtt.h................................................................................................................................................................................................................................................................................................................................................................................................................................t.h..ph..................hphulauaCts.........................................t.tt.ss.C.....op..spss.a.s.hssh......p.http.......................................thsl...P.s..shps............p...h..h.....hph.....hh........shhhluhh....hshl...shlh.sh..h................................shhhp........................................................................hhsh...h...s..........hlhshluh.lhshlushls....ss.h.as.h...httthppt...............htsphGsp..h..h.sh..hWhuh...shsllshh.h.....................................	0	135	305	487
+6516	PF06688	DUF1187		Protein of unknown function (DUF1187)	Moxon SJ	anon	Pfam-B_22781 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of around 62 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi. The function of this family is unknown.	20.70	20.70	22.20	40.90	19.00	18.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.16	0.72	-3.85	2	125	2009-09-11 12:17:23	2003-07-28 15:25:53	6	1	113	0	2	55	0	58.80	68	86.50	CHANGED	YpIsATIcK.GGsPspWT+YSc..hTtpECcK.hStcKEAGhshp.cV+l.sF.Cccl.sp	.YKITATIEKEGGTPTNWTRYSKSKLTKSECEKMLSGKKEAGVS.REQK.VKLINFNCEKL.SS.............	0	1	1	1
+6517	PF06689	zf-C4_ClpX		ClpX C4-type zinc finger	Bateman A	anon	Pfam-B_465 (release 10.0)	Domain	The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of proteins, and possesses a putative zinc finger motif of the C4 type. This presumed zinc binding domain is found at the N-terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate specificity component of the ClpXP protease and as a molecular chaperone. The molecular function of this domain is now known.	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.41	0.72	-4.44	130	4410	2009-01-15 18:05:59	2003-07-28 15:29:21	8	8	4219	9	955	2727	1965	40.10	59	9.68	CHANGED	phpCSFCGKspscVc+LI.AGs.s...saICcEClclspcIlpc-	.........h.lhCSFCGKoQc...-...V...+KL......I.....A..G.P.u.........VaIC....DECl-LCs-IIcEE.......	0	326	634	816
+6518	PF06690	DUF1188		Protein of unknown function (DUF1188)	Moxon SJ	anon	Pfam-B_22902 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of around 260 residues in length which seem to be specific to Methanobacterium, Methanococcus and Methanopyrus species. The function of this family is unknown.	26.60	26.60	27.20	60.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.64	0.70	-5.24	8	32	2009-01-15 18:05:59	2003-07-28 15:31:43	6	2	30	0	21	29	2	244.00	40	96.65	CHANGED	hchGITEoVKTlpS+l+ltDIlp-IucKKAsAIptaLEsEcFc..pAlIFGuYLoGualApsLsKcs.EVhlVDIpPaL+cll..spsI+Fh.......chhsshss.s.DLlVDLTGLGGlsP-hLS+LsPcVLIVEDPpGsh.DtsIpphsNTpERLs...pusK+GlL+TactuhsoKTSGTMTLoV-slp-uss-lpElDGVLYAlPsL+aaEtlLF+.E+DhcpFLsclspPAlTVSSLc-...h-sDElLpcNluhIpShVcE	................chGITEpVKThcSch+lhDIlpcIscKKupAlp.aL-utchc.......psllhGuYLoGsalAptLpc.t.pcVhllDIpPal+pll..spsl..cFh.........chhps..ph..s.DLllDhTGlGGl..ss-hLuchs.scVhIVEDPpush.DptIhchsNT.cRls....sutc+GlL+Ta..uhhSKTSGTMTLTl-slhcusp-lpcl-GVLYulssLcaaEtllF+.E+DhcKFlsplstPAlTlSolsc......-s-cllppNlscIpShl.......................................	0	6	11	17
+6519	PF06691	DUF1189		Protein of unknown function (DUF1189)	Moxon SJ	anon	Pfam-B_22923 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.	20.70	20.70	20.80	21.00	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.49	0.70	-5.06	12	358	2009-01-15 18:05:59	2003-07-28 15:44:05	6	2	333	0	41	223	1	238.10	27	93.78	CHANGED	MNlFpphhKSlYSP+DIAthRFQuIGKoIlYlhLLollsslPssYahsoslppuhsshppslpcDlPsFpIpsGcL....ps-tppsIphppsshsIlFDsosohpscp....ltsppsululLK-chll.sssGpsQphsYshhss.slsKcDlhshlsphculh..llslhslllalhssAhpFIpVolLAhIGhllpshtp+pLsY+plWploAYSlTLsTVFFsIMcsLphsVPsshhlsahVshIlLaLslKElP	...............................phhp.hhh.uh.a.sspchtph+..ht.thhKsIlYlhlLshlhslP........hshhhh....sslp........pslphspptIsc......clP.D.FpIc.NGpL.......p.s.c.tp.ps..h..h..p.ps...........sh....l...hs....FD.P.s..up.hsppp............l...s....pt.p....u....l...hhL...p.Dchll...hs..........s.......G.....t.o...p.o........h.........sYs.........p...hh...h...........slsp...psl.p....s...hl.s..t..h.....csh.....h........h.hlh.l.hh.llla...lh.plhhhF...l....s....l..h.l...lA.h.l..G...t.h.....h.u.th........p..p....pl.sa..tp..shplssYuhTlPslhhhIhph......h..p.....hh..hssuhhlh..hhlshlhha.lsh+p......................................................	1	16	31	35
+6520	PF06692	MNSV_P7B		Melon necrotic spot virus P7B protein	Moxon SJ	anon	Pfam-B_22334 (release 10.0)	Family	This family consists of several Melon necrotic spot virus (MNSV) P7B proteins. The function of this family is unknown.	20.80	20.80	22.60	22.10	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-8.99	0.72	-4.19	2	21	2009-01-15 18:05:59	2003-07-28 15:45:34	6	2	3	0	0	21	0	60.50	83	73.55	CHANGED	MACY+CDSSPGDYSGALLILFISFVhFhITSLSPQGNTYVHHFDNSSlKTQYVGISTNGDG	.........MAChRCDSSPGDYSGALLILFISFVFFYITSLSPQGNTYVHHFDNSSVKTQYVGISTNGDG...	0	0	0	0
+6521	PF06693	DUF1190		Protein of unknown function (DUF1190)	Moxon SJ	anon	Pfam-B_22972 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 212 residues in length and is known as YjfM in Escherichia coli. The function of this family is unknown.	21.80	21.80	22.40	22.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.35	0.71	-4.19	26	1138	2009-01-15 18:05:59	2003-07-28 16:26:18	6	2	707	0	103	463	18	162.00	45	76.05	CHANGED	cscps...sslapsss-Chpsssshst.....pCpsAYppAhscttcsAP+YsoptsCcu-FGtspCst.......................spsppu...............Gt..ahPhMuGahhuph...hsssst.h....ssQPlapots.....t....s.tspahsusGpshssuhpss...pshssscs........shtspssso+sl..SRGGFG..posuupouhGu	................................sDtssohYpsssDC.ssssst.us...........................CssuaNNAhpEt.psAPKasTp-sC.ucFG.tpC...............................................pspppS...................WhPlhuG.ahhuRl.............hts..s.t..........spQslasSts.su............suhshapssoGc..hstutsG.........+p...h.sscT........................uhus..tss.....T..s.....oTV....oRGGFG.cSsutpupht.............................................................	0	15	40	66
+6522	PF06694	Plant_NMP1		Plant nuclear matrix protein 1 (NMP1)	Moxon SJ	anon	Pfam-B_22388 (release 10.0)	Family	This family consists of several plant specific nuclear matrix protein 1 (NMP1) sequences. Nuclear Matrix Protein 1 is a ubiquitously expressed 36 kDa protein, which has no homologues in animals and fungi, but is highly conserved among flowering and non-flowering plants. NMP1 is located both in the cytoplasm and nucleus and that the nuclear fraction is associated with the nuclear matrix. NMP1 is a candidate for a plant-specific structural protein with a function both in the nucleus and cytoplasm [1]. 	25.00	25.00	25.50	25.50	20.90	24.80	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-11.89	0.70	-5.50	2	45	2009-01-15 18:05:59	2003-07-28 16:31:52	6	4	27	0	22	47	0	238.30	52	89.86	CHANGED	MAuKQMEEIQ+KLuhLpYPRANAPAQSLLFAGhERYtLLEWLFF+LLGD+SPFoQQNhQGDulDRDEEssRIQaLAEIApFLGITsosDsEAIQGRGSYE-RhEhL+LIVDLVEAShYADNPEWSVDcQltKDlQLlDuIAEKQuQIFSEECKLFPADVQIQSIYPLPDIu-LEhpLS-.op+h.sLQpMVp-LASKasYNPsE-Ys-sEhKLRtaLpSFL-Ts+oFNTIYTKEI+PWTHMMEVPQLHGFGPAANRLLEAYphLhKFLGNL+sLRDSasAhAAGS..osusEPSSVT+IIS-CEoALThLN+sLuILSsSlAREp	...........................................M-.lppKL..LtYsRupssuQpLLaA.GhERYtLL-WLFF+LLGD+SP.FoQQshQG-.uh.RDEEssRlQhL..hcIAph............LGlssphD.-sIpGcsoacpphthlp.I......l-lV...-ushhu-N...EaS..........lD-QhtKDlpLlDuIu..E+Qu...lFS-..ECKLFPsD.V..Q.I.............Q.....S..h..slPDls-LE.phuc.s+h.......h.....sLQphVp-LAuKas.Y.NP.sE-as.EsE.p.L+tpLpoFL-os+sFNhIYoKEI+PWTHhMElPQLHGhGPAANRLLEuYphLLKFLuNL+sLRDSasAhuhGS...........s......ustPSSVo+IlS-CEsALThLNcsLuILSsSlAR-.....................................	0	6	17	20
+6523	PF06695	Sm_multidrug_ex	sm_multidrug_ex; 	Putative small multi-drug export protein	Vella Briffa B	anon	Pfam-B_16747 (release 10.0)	Family	This family contains a small number of putative small multi-drug export proteins.	26.10	26.10	26.20	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.52	0.71	-3.95	36	377	2009-01-15 18:05:59	2003-07-28 16:38:41	6	1	337	0	147	343	71	120.40	33	70.77	CHANGED	ELRGAIPhul.shGls.hpuhllullGN.lLPl..PhlLhhlchlhpahpc.hthhpt....lhshlhc+scc.pspplc+a...u..alGLhlFVAIPLPGTGsWTGuLsAhlLslch+cuhhAlhlGlllAull	....................ELRGAlPhul..sh....G.....ls....h.tuhllu...l.lGN...hlPl.............Phlhhhhcplh..pa........htc....p..h..htt..........hhs.h...hhc+u...cc...tsppl..c+h...u....ahGLhLFVuIPL.PGTGAWTGsLhAslLshch+puhhAlhlGlllAulI........................................................	0	64	112	132
+6524	PF06696	Strep_SA_rep		Streptococcal surface antigen repeat	Moxon SJ	anon	Pfam-B_22674 (release 10.0)	Repeat	This family consists of a number of ~25 residue long repeats found commonly in Streptococcal surface antigens although one copy is present in the HPSR2-heavy chain potential motor protein of Giardia lamblia (Swiss:Q24984). This family is often found in conjunction with Pfam:PF00746.	21.70	21.70	21.70	21.70	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.60	0.72	-6.88	0.72	-4.10	32	550	2009-01-15 18:05:59	2003-07-28 16:42:00	6	17	71	12	39	523	0	24.90	51	8.42	CHANGED	AsYpAtLupYps-LAplQKsNu-tc	..AsYpApLupYps-LA+VQKsNA-sc...	0	3	11	25
+6525	PF06697	DUF1191		Protein of unknown function (DUF1191)	Vella Briffa B	anon	Pfam-B_16754 (release 10.0)	Family	This family contains hypothetical plant proteins of unknown function.	26.40	26.40	26.40	35.50	25.90	26.30	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.99	0.70	-5.59	11	98	2009-01-15 18:05:59	2003-07-28 16:46:46	7	4	18	0	70	84	0	258.40	34	85.36	CHANGED	po..pttslpsuphLDshlpDauh...Ruhp.+h+TGllYpl.sLPuNL..SGIchussRlRuGSLRRpGs.cas...-FslPsGlsVpPhscRlllVhpNLG.NaSs.lY...Ysls.G..YcllSPVLGLLsYsAsspusssp......pls.lhus.tsPIplsF..s.hsssstss.......usshCssFs.sG...sss.hss..ss.sCtsp.c.pG...HaulVl.ssps.tss..st..................ttp.ttW+.....hhsuhssGshlLGlL..llstls+hK+...+p+hc-MERcA.psE..sLc.suhVG+oRA.PsAssoRTpP	.....................t.......tsscsLDthlp-hAh......+uh.....p..+TGhlass...plP.uNL......oGl..clu..slRlRuGSLhppGs...pat....pFtlPstlhs.......pPhs.c.RlslVapsLG...NaSs.hY...Y.sls..G..YphluPVlGLhsYsusshssss.......pls.lhus..tsPIhlpF..sshpssst..s........ssspClsFshsG......psp...hp..shsssssChsp.p.pG..HaulVV.psps..ss.sss..........................................ptp.phWh.....hls....u....h....ssGhh.h...LslL...s..hl.lh.hhs..+h++.cp+hppMERpA.psEsLp.hshVGco+A.PsAssTRTpP..........	0	8	45	56
+6526	PF06698	DUF1192		Protein of unknown function (DUF1192)	Moxon SJ	anon	Pfam-B_22780 (release 10.0)	Family	This family consists of several short, hypothetical, bacterial proteins of around 60 residues in length. The function of this family is unknown.	24.30	24.30	24.40	24.40	23.80	24.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.86	0.72	-4.16	27	170	2009-01-15 18:05:59	2003-07-28 16:48:47	6	1	169	0	63	127	143	58.50	47	83.82	CHANGED	DD.-hP+p+ss...p.lupD.LohLSV-ELppRIuhLpuEIsRlcsthspKpAs+sAA-ulF+	...................D-.Dhs+.+su.......t.lupD.LulLSVsELcpRIALLpuEItRLcA-ht+KssoRuAAEALF+....	0	17	37	47
+6527	PF06699	PIG-F		GPI biosynthesis protein family Pig-F	Wood V, Studholme DJ, Finn RD	anon	Pfam-B_8602 (release 8.0)	Family	PIG-F is involved in glycosylphosphatidylinositol (GPI) anchor  biosynthesis [1-3].	21.70	21.70	21.80	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.67	0.71	-4.36	25	274	2009-01-15 18:05:59	2003-07-28 17:00:18	6	13	240	0	190	266	2	180.90	27	70.52	CHANGED	sallshhhlhlhhh..hhhh.hht...sshssLth.slhshslhpllYhhlp...hsssspp...............spp.................pshhhtlhull...lslllosPhhhhlllLaGAPl.lpplhcTaLhulHhShLshhPlhslhusshps..WpclFshpt.hs...hht.....sslssllGuWlGulPIPLDWDRPWQpWPIollsGAalGhhlGh.hlushh	...................................................................................................................h.........h.h.......h....ht....s.h.hhh....h..hhh..hha.hhlp....sststt.......................................................................................thh.thhphh...lhhlhus.hhthlhlLaGAPl..h.ph..hhc....Thlh.....uhhhohLsh..h.Ph.....hh.....lhGs...........s.hps..................Whpl.h....sh..t...t.shs...............hht................sslusllGA.WlGAhPIPLDWDRsWQtWPlshshGuhhGhhlGhhlu...h.............................	0	53	97	153
+6529	PF06701	MIB_HERC2		Mib_herc2	Artzt K, Studholme DJ	anon	Pfam-B_6026 (release 8.0)	Domain	Named "mib/herc2 domain" in [1]. Usually the protein also contains an E3 ligase domain (either Ring or Hect). 	19.40	19.40	19.50	19.80	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.46	0.72	-4.01	9	640	2009-01-15 18:05:59	2003-07-28 18:16:04	8	155	98	2	410	595	5	64.20	47	5.03	CHANGED	GsRVVRGsDW+Ws-QDGs.uthGpVhp.......tupcuhlsVpWDsGspNsYRhGhcGpaDL+ls-ss	.....GsRVVRGsDW.....c..W..sc.QDGGpG...p......hGpVsp.......................................t..s..sc........uhlsVpW.D.sG.s.p.ss..YRhGhc.Gt..aDL+lhs.....................	1	148	173	300
+6530	PF06702	DUF1193		Protein of unknown function (DUF1193)	Vella Briffa B	anon	Pfam-B_16766 (release 10.0)	Family	This family represents the C-terminus of several hypothetical eukaryotic proteins of unknown function. Family members contain two conserved motifs: DRHHYE and QCC, as well as a number of conserved cysteine residues.	23.60	23.60	23.60	23.60	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.56	0.70	-4.93	19	305	2009-01-15 18:05:59	2003-07-29 09:31:20	7	7	92	0	209	297	0	201.40	42	44.38	CHANGED	Fhhssu..............sNhCFaGcC.YYCcs-aAlCG..ps-hlEGSlshaLPs..hhshppaRsPWpRoYpcscp.AcWEssssYCss.VKpp.PYDpGtRLLDlIDhulFD...................FLIu.........Nh.......DRHHYEoFpchsst.......shl.............................................laLDNu+uFG+ss+DEhSIL..APLhQC.ChlR+STh.RLpllp..s.ttLocshcEuhtpD....lsPlLscsHlpAl-RRLthlhpslcpChcppG..tpVl.pD	............................................................hosusNhCFaucC..YYCpppcslCG..ps..c..hEGSlshaLPs....hh.htphRpPWtRoYpc.tph.A....pWEh.....s...sYCpt...V+ph.P...Y..s..pu..RLLDlh...DhslFD...................F.LhG....................NhDRHHYE..sF..pt..s.st................shl...................................................................laLDNu+G.F...Gp.spD..EhSI.L...uP.....L.QC.C............h...........IR+STh.+LphLtt...s.....htLopl..hccuh.t.pD......lsP...l...L...s-....sHLpALDRRLthlLpsVcpChcp......G...ttVh...............................	0	51	67	138
+6531	PF06703	SPC25		Microsomal signal peptidase 25 kDa subunit (SPC25)	Moxon SJ	anon	Pfam-B_22374 (release 10.0)	Family	This family consists of several microsomal signal peptidase 25 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 25 kDa subunit (SPC25).	22.80	22.80	23.30	23.40	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.98	0.71	-4.66	32	365	2009-09-10 23:37:10	2003-07-29 10:05:20	6	7	290	0	231	339	3	149.90	27	76.60	CHANGED	slKpshD-ulsshltph....G..........appsapLhDs+LhlGhsulslAshuhhhDh..hhsa.po+.shhhhsVshYhlLsslLhhashhhEKshlahuppct.....sscplpls...........ophpK.....asPhYpl..plshpcspstt.....p..hphpts.hscaFstsGhhhtshapphlsp.lssl	..............................tlKpslDDulpphLhpt.....t.....................atEsatLhDsRLhlshhushlAhhuhhaDh..hhsFspo+....shlhhsVh............s...........Y...Fl...h.ulLslasha.h..E.Kshhhhuhpct.............ssct.....hplu.............Sphc.+.............asshYpL..plshtsspstt..........pp..hphsps.hspa...........FcpsGhlh.shapp.lsphhp..h.......................................	0	84	131	191
+6533	PF06705	SF-assemblin		SF-assemblin/beta giardin	Moxon SJ	anon	Pfam-B_22934 (release 10.0)	Family	This family consists of several eukaryotic SF-assemblin and related beta giardin proteins. During mitosis the SF-assemblin-based cytoskeleton is reorganised; it divides in prophase and is reduced to two dot-like structures at each spindle pole in metaphase. During anaphase, the two dots present at each pole are connected again. In telophase there is an asymmetrical outgrowth of new fibres. It has been suggested that SF-assemblin is involved in re-establishing the microtubular root system characteristic of interphase cells after mitosis [1]. 	30.00	30.00	30.30	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.61	0.70	-5.23	6	409	2009-01-15 18:05:59	2003-07-29 10:19:12	6	3	47	0	84	409	2	191.20	61	89.87	CHANGED	ssousKLEHVsE+Fuuhas-lEpEKQsRRlsEuoRhpllpEuls+LEKulEAElKRRAESDKQlQsHFEuEl+sLpERptpQlsDhpsulKsAl-uLup+lpDLHoll+-ER-pRRsDIEHLAsSLVsKVNECVuAlDEERspRhpcpshhhK+luEDlhplpp+lDTEKssR-u-lSuLRoE.lH-sluNRNlsDEQFcshVLDElsulKuALshEREERlAEDDEIVQAlNDYT+ALQ-GL+lVss	.........................................................................hcsR...RVDDDTRVKMIKDAIAHLD....RLIQTESRKRQuSFEDIRE...EVKKSADNMY.LTIKEEIDT.MAANFR.KSLAE.......MGDTLNNVETNLQNQIAI..HNDAI...AALRKEALK.SLNDLETGIATENAERKKMYDQLNEKVAEGFARISAAIE...KETIARERAVSAAT..TE.Ls.ssh.............................................................................................	0	59	69	80
+6534	PF06706	CTV_P6		Citrus tristeza virus 6-kDa protein	Moxon SJ	anon	Pfam-B_22973 (release 10.0)	Family	This family consists of several Citrus tristeza virus (CTV) 6-kDa, 51 residue long hydrophobic (P6) proteins. The function of this family is unknown.	25.00	25.00	30.10	30.00	20.00	18.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.69	0.72	-4.48	2	15	2009-09-14 12:01:29	2003-07-29 10:22:59	6	1	2	\N	0	16	0	50.70	86	98.70	CHANGED	MDCVIQGFLTFLVGIAVFsAFAtLIIIVITIYRCThKPVRsASPYGTHATl	MDCVIQGFLTFLVGIAVF..SAFAGLIIIVITIYRCTTKPVRNsSPYGTHATV.................	0	0	0	0
+6535	PF06707	DUF1194		Protein of unknown function (DUF1194)	Moxon SJ	anon	Pfam-B_22986 (release 10.0)	Family	This family consists of several hypothetical Rhizobiales specific proteins of around 270 residues in length. The function of this family is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.22	0.70	-5.35	35	226	2012-10-10 16:07:06	2003-07-29 10:26:08	6	6	125	0	81	566	155	199.90	36	75.78	CHANGED	ss.DltLlLAVDVStSlDtpEhplQR-GaAsALssP-VhpAlhu.GshGclAlshhEWuGsspQplllsWolIcsspsApshAspltssPpttspt.TuIusAlsa.usshhspsshtuhRRVIDlSGDGssN....pG.sPs..tAR-tshstGl.sINGLsIhssss.s..........sLssYYpssVIuGPGAFVlsspsac-FscAlRRKLlhEluuhs	...........................................................................................s.DltLlLAlDVStSlDt...sEh..pl..Q..pcGh.A...t.A.L.p.s..sp.lh.pA.l.hs...u....G.plAlshhEWuu.spQ........plllsWphIss...tsupshAspl..tst.......s.....p.t.....tsph..TulusAlth.us.s.l.h..s.....ps.s....h.......uhR..+....VIDlSGDG..sN..........pG...sPs......tuRctsh..s.....p.G..l...sIN..GL...sIhspss...........................sLs.t.YYpspVIuGP......G.....AFVhsspshp.-FscAlRcKLlhElus.s..................................................	1	15	38	51
+6536	PF06708	DUF1195		Protein of unknown function (DUF1195)	Moxon SJ	anon	Pfam-B_22828 (release 10.0)	Family	This family consists of several plant specific hypothetical proteins of around 160 residues in length. The function of this family is unknown.	25.00	25.00	78.30	78.00	21.70	22.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.11	0.71	-4.80	7	56	2009-01-15 18:05:59	2003-07-29 10:29:54	6	2	19	0	25	53	0	141.80	53	85.58	CHANGED	M+tsct...hPsoTsosssp....hsupppsuttu..hhG+GRYKhWALAAIhLLAhWSMhTGoVoLRWSuGsl...sphs-DlshPhhDDLDVLEMEEREKlV++MWDVYTpot..pl+LPRFWQEAFEAAYEELsSDsssVp-AAlSEIA+MS.lRplpl-sss.cSs	.................................s..............thts....utsu..lhGKGRYKhWALAAIhLLAhWSMhsuoVoLRWS.u..GsL...sphssDlssPlh.DDLDsLEMEEREKlV++MWDVYTpop...clRLPRFWQEAFEAAYEELsuDs.ssVR-AAlSEIA+MS.l+plpl-.ss.p..p.................	0	3	14	20
+6537	PF06709	DUF1196		Protein of unknown function (DUF1196)	Moxon SJ	anon	Pfam-B_23162 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 51 residues in length which seem to be specific to Vibrio cholerae. The function of this family is unknown.	21.70	21.70	24.90	24.70	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.76	0.72	-4.03	2	41	2009-01-15 18:05:59	2003-07-29 13:17:12	6	1	18	0	4	14	0	48.50	92	96.46	CHANGED	MTVPLEAFVMCVFLMPTLPFKGVAKGIYAKQHSIKsaHIHKTKMLHlDIFR	MTVPLEAFVMCVFLMPTLPFKGVA.KGIYAKQHSIKsHHIHKTKMLHIDIFR.	0	4	4	4
+6539	PF06711	DUF1198		Protein of unknown function (DUF1198)	Moxon SJ	anon	Pfam-B_23016 (release 10.0)	Family	This family consists of several bacterial proteins of around 150 residues in length which are specific to Escherichia coli, Salmonella species and Yersinia pestis. The function of this family is unknown.	25.00	25.00	42.00	41.80	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.85	0.71	-4.39	5	511	2009-01-15 18:05:59	2003-07-29 14:21:16	6	1	506	0	25	130	1	147.00	77	97.65	CHANGED	MlWIILATLlVVFIVGFRVLTSDTRRAI+RLSERLsIcPVPIESMIDQMGKTAGsEFIRYLcRPsEuHLQNAAQVLLIWQssIVDuSDcNlphW+RLLpKARLAAPLT-sQlRLALGFhRELDPDAaELssFQpRYNphFpPE-GVaW	...MIWIMLATLAVVFVVGFRVLTSGuRKAIRRLS-RLNIDVVPVESMlDQMGKoAGcEFLRYLHRPDESHLQNAAQVLLIWQlVIVDGSEQNLhpWHRlLQKARLAAPITDAQVRLALGFLREhEP-MQ-INAFQhRYNAFFQPtEGVHW.................	1	1	5	14
+6540	PF06712	DUF1199		Protein of unknown function (DUF1199)	Moxon SJ	anon	Pfam-B_23160 (release 10.0)	Family	This family consists of several hypothetical Feline immunodeficiency virus (FIV) proteins. Members of this family are typically around 67 residues long and are often annotated as ORF3 proteins. The function of this family is unknown.	25.00	25.00	111.00	110.70	21.60	18.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.53	0.72	-4.15	5	6	2009-01-15 18:05:59	2003-07-29 14:25:47	6	1	2	0	0	4	0	51.80	73	79.54	CHANGED	MLaRNScsVPAuIYRSNNIFsNNQuSGSMETSTISSPSRRIRNNFLGLLGTR	ML.RNuchVPs.IYRsNNIFssNQsSGSMETSTISSPSRRIRNNFLGLLGTR	0	0	0	0
+6541	PF06713	bPH_4	DUF1200;	Bacterial PH domain	Moxon SJ, Bateman A	anon	Pfam-B_23245 (release 10.0)	Domain	This family consists of several hypothetical proteins specific to Oceanobacillus and Bacillus species. Members of this family are typically around 130 residues in length. The function of this family is unknown. Members of this family have a PH domain like structure [1].	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.36	0.72	-4.11	46	441	2012-10-04 00:02:25	2003-07-29 14:29:16	6	2	256	0	64	351	8	72.70	29	53.89	CHANGED	TpYpl..psspLhlpsG.hh+pc.IslpcIppIp.sps.hs....usAhohcplpIpYs..........thsp.lhISPcccccFlptLpcps	.............+Ypl..psssLhl+tG.hh+pc...Islc-I+pI..cpstp.h........u.ths.hcpLEIp.Ys..........tacs.hhl..PpccccFlshlccps............................................	0	24	53	57
+6542	PF06714	Gp5_OB		Gp5 N-terminal OB domain	Bateman A, Mesyanzhinov VV	anon	[1]	Domain	This domain is found at the N terminus of the Gp5 baseplate protein of bacteriophage T4.  This domain binds to the Gp27 protein [1].  This domain has the common OB fold [1].	25.00	25.00	27.10	25.80	24.70	23.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.17	8	60	2009-09-11 05:11:09	2003-07-29 14:46:33	6	7	59	3	0	62	590	132.00	37	21.49	CHANGED	GlHPsQKs+u-shGlsTE-LLWMoshpslTSAAlSGIGpSPTGlVEGTaVaGaFLDKapQsGllLGTYsGIYp-KPssscGFsDPsGpYP...RYlGNDVNlLARGGhp.clu.sp..soshI...........QDtNoslAlsPD-pPhsEI.sDssPc	........G.Hs..+.ps-spGlPTEcLPWholl.PsooAuhS.G.lGtSsTGll.pGotVhGaaLD.ch.pps.slllGoh...sGhhpppssppcGFsDPsGpYP...hhlGsDsshLstGs.....phh.st..ps..h...........pstNhshuh.sst.s.st...sspP..........................................................................	0	0	0	0
+6543	PF06715	Gp5_C		Gp5 C-terminal repeat (3 copies)	Bateman A, Mesyanzhinov VV	anon	[1]	Repeat	This repeat composes the C-terminal part of the bacteriophage T4 baseplate protein Gp5.  This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerise to form a beta solenoid type structure [1]. This family also includes repeats from bacterial Vgr proteins.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.33	0.74	-7.26	0.74	-3.66	89	445	2009-01-15 18:05:59	2003-07-29 16:39:43	7	22	205	27	84	435	64	24.00	35	5.73	CHANGED	usto.hsVtuNpohsVsu.spopsls	.......tspopsVtsNRTpsVss.NcT.ols..........	0	16	36	60
+6544	PF06716	DUF1201		Protein of unknown function (DUF1201)	Moxon SJ	anon	Pfam-B_23269 (release 10.0)	Family	This family consists of several Sugar beet yellow virus (SBYV) putative membrane-binding proteins of around 54 residues in length. The function of this family is unknown.	20.90	20.90	22.30	22.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.85	0.72	-4.15	2	5	2009-01-15 18:05:59	2003-07-29 16:55:40	6	1	3	0	0	5	0	51.60	68	96.63	CHANGED	MDCVLRSYLLLAFGFhICLFLFCLVVFIWFVYKQILFRsTs.SNEARaN+STVV	MDCVLRSYLLLAFGFLICLFLFCLVVFIWFVYKQILFRNTPPSNEARFNRSTVV.........	2	0	0	0
+6545	PF06717	DUF1202		Protein of unknown function (DUF1202)	Moxon SJ	anon	Pfam-B_23300 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 335 residues in length. Members of this family are found exclusively in Escherichia coli and Salmonella species and are often referred to as YggM proteins. The function of this family is unknown.	21.10	21.10	21.30	22.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.83	0.70	-5.15	4	434	2009-01-15 18:05:59	2003-07-29 16:59:04	6	1	410	0	5	129	3	303.60	78	92.48	CHANGED	hLhoG.shADspsPTENILK-QFpKQYHGILKLDuITLKNLDucGNQATWSAEGDlSSu-DLYThVGpLADY.llEpTWTKDKPVKFSAMLTSKGTPASGWoVsFYShQhAASD+GRslDDIKTNsKYLIVNS-DFNYRFuplcuuhssQKsSIsuLcc-lpALDKphlsApKtADAYWGKsAsGKphTRt-AFKKlpppRD-FNKpNDSpsFAhKY-KEVYQPAlsAC+KQSEcCYEls....IQQKRDhDIpEQRRQsFLKSpcLsRKlQsDWITLEKGQYPLshKVpclppppssIhMKIcDINpu...aK+	..........................................MLMTGNuWADGEPPTENILKDQFKKQYHGILKLDuITLKNLDAKGNQATWSAEGDVSSSDDLYTWVGQLADYELLEQTWTKDKPVKFSAMLTSKGTPASGWoVNFYSFQAAASDRGRVVDDIKTNN.KYLIVNSEDFNYRFSQLEoALNsQKNSIPALEK-VKALDKQMVAAQKAADAYWGKDANGK...QMTR..E-AFKKI.HQQRD-FNKQNDSEAFAVKYDKEVYQPAIAA.CHKQSEECYEVP........IQQKRDFDINEQRRQTFLQSQKLSRKLQDDWlTLEKGQYPLTMKVSEINSKKVAILMKIDDINQANERWK.K...............................................................	0	2	2	3
+6546	PF06718	DUF1203		Protein of unknown function (DUF1203)	Moxon SJ	anon	Pfam-B_23313 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 155 residues in length. Family members are present in Rhizobium, Agrobacterium and Streptomyces species.	20.60	20.60	21.40	21.00	20.50	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.45	0.71	-4.28	20	173	2009-01-15 18:05:59	2003-07-29 17:06:05	6	1	171	0	60	169	7	117.00	36	73.61	CHANGED	GhPCRpsL+cuctG-plLLLuYpPa........ssssPYsEsGPIFlptpsspttsu.-slP...........sl.sutshslRGYsu-s+Il..sucllsss-.......hsuthcclLscs-VAalHVRsAcpGCYtsRl-R	..GhPCRhsL+cupsG.Ep.llL.lsYp.h........ssssPYptsGPIFl+ttssssh....s..s....t....lP...........hl.psch...hslRuYsucshlV..sucVspuss.............lcptlc.clFs.ss..-V..sYlHl+sAc.GCatsclcR............	0	10	36	47
+6547	PF06719	AraC_N	AraC_N-term; 	AraC-type transcriptional regulator N-terminus	Vella Briffa B	anon	Pfam-B_16798 (release 10.0)	Family	This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains [1]. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating [2]. All family members contain the Pfam:PF00165 domain.	24.20	24.20	24.30	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.65	0.71	-4.92	170	1635	2012-10-10 13:59:34	2003-07-29 17:09:29	8	4	1088	0	429	1324	58	152.60	33	50.71	CHANGED	Ts..lsulplhR.sspsst.h.sslYcPulsllsQGpKpshlG.ccsapYcstcYLlsolslPhpsplhpASs-pPhLultlclDhshls-Llhchs.ts.tstsstt.................ulsssphsssLh-AhhRLlcLLcp.P.p-hslLuPhlhREIhYRLLpGspGstL	....................................lsslplhp.sp.ps.h.s.hs..ss.h.Y.cPul.sllhQGpK.hsh..l..u..c.c.s..a....p..YDsscYLlloVsLPhpscs...Aos..-tPhhulpLslDht.lt-Llhchspstt.hps.shst.................Glssuslsp..pllsAs.RLL.c..l.h..c..p.P..hD..t.p.l.Lus.IhREIlY+lLpGspGstL...........................	0	101	207	325
+6548	PF06720	Phi-29_GP16_7		Bacteriophage phi-29 early protein GP16.7	Moxon SJ	anon	Pfam-B_23362 (release 10.0)	Family	This family consists of several bacteriophage phi-29 early protein GP16.7 sequences of around 130 residues in length. The function of this family is unknown.	25.00	25.00	47.60	46.80	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.70	0.71	-4.48	2	6	2009-09-10 16:38:04	2003-07-29 17:11:43	6	1	5	10	0	7	0	129.30	60	99.11	CHANGED	MEAILMIGVlsLCVIFLLSGRNNKKhQEARELEDYLEDLNpRlsQRTQILSELNEVIoNRSlDKoVNhSACElAVLDLYEQSNIRIPSDIIEDhVNQRLQoEQ-VLNYIETQRTYWKLENQKKLYRGSLK	.......................MEAILMIGVlsLCVIFLLSGRNNKKKQEsRELEDY..LEDLNpRlsQRTQILSELNEVIoNRSlDKoVNhSACElAVLDLYEQSNIRIPSDIIEDlV.NQRLQoEQEVLNYIETQRTYWKLENQKKLYRGSLK..	0	0	0	0
+6549	PF06721	DUF1204		Protein of unknown function (DUF1204)	Vella Briffa B	anon	Pfam-B_16832 (release 10.0)	Family	This family represents the C-terminus of a number of Arabidopsis thaliana hypothetical proteins of unknown function. Family members contain a conserved DFD motif.	21.00	21.00	21.00	25.10	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.41	0.70	-5.11	2	9	2009-09-11 06:55:55	2003-07-29 17:14:31	6	2	2	0	4	16	0	169.10	40	38.05	CHANGED	c+.s.Lhc+.lcShShEAsphKsthtsLAhp+phhup...-hsRsp.Dhcc.+cKhsELtsRhhSEhKRLRpRR.cYAp..pppAL.+hAs.Fpu..........DhlthpPKFh-aNQVsGNlthL-tLVEuGElEhKSs-hM.RLlADt-tLcAEVcuFtIT-l.csDFDVhTLFtcl..-p+.....sus.s.TEuEc.t-spsEstuQtt.chsG.h.scsthAss.-	...................................................................................................................p.KhscLtsRhhuE.KRLRppR.chAc..p..pptL.+htp.hptchptl+hcl.DcphthpPKFh-h........NQVsGslthL-tLl-sGphEhKSs-hM.RLlADt-tLcAEVcuFtIT-l.csDFDVhTLFtcl..-p+.....sus.s.TcuEc.t-spsEstuQtt.chsG.h.scsthAss.-..................	1	4	4	4
+6550	PF06722	DUF1205		Protein of unknown function (DUF1205)	Vella Briffa B	anon	Pfam-B_16780 (release 10.0)	Family	This family represents a conserved region of unknown function within bacterial glycosyl transferases. Many family members contain Pfam:PF03033.	20.70	20.70	20.70	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.38	0.72	-3.75	33	513	2012-10-03 16:42:30	2003-07-29 17:22:06	7	8	340	18	67	391	0	95.10	41	24.87	CHANGED	lDssPsShch...s...su..hssl..shRYVPYNG...uVlPs..WLhps....ssRs.RVslTLGsottp.h.tsst.sslscllsulucL.DsElVsTlsspptttL.uslPsNVR	.................................IDssPPShpl........s..........su.....pPsl...sMRYV....PYN..Gu....AVh.s.Whccs.........scR.t.R.lhloLGTspsh...st.........Ghc.......................hluhlh-..u..su....-l.DAEl.llpls.ss.sps.sL..psLPsNVR.............	0	21	47	59
+6551	PF06723	MreB_Mbl		MreB/Mbl protein	Moxon SJ	anon	Pfam-B_471 (release 10.0)	Family	This family consists of bacterial MreB and Mbl proteins as well as two related archaeal sequences. MreB is known to be a rod shape-determining protein in bacteria and goes to make up the bacterial cytoskeleton. Genes coding for MreB/Mbl are only found in elongated bacteria, not in coccoid forms. It has been speculated that constituents of the eukaryotic cytoskeleton (tubulin, actin) may have evolved from prokaryotic precursor proteins closely related to today's bacterial proteins FtsZ and MreB/Mbl [1].	56.40	56.40	56.40	56.40	56.30	56.30	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.76	0.70	-5.84	31	4314	2012-10-02 23:34:14	2003-07-30 09:48:34	8	4	3147	5	973	7141	4347	321.20	54	95.81	CHANGED	usDluIDLGTANTLV..YV+G+GIVLsEPSVVAlcps.....sppllAVGpEAKpMlG+TPusItAlRPh+DGVIADa-hsEpMLKaFIp+lps..ppth.hpP+lllClPoGlTsVE+RAlp-uuppAGA+cVhllEEPhAAAIGAGLPVpEPsGsMVlDIGGGTTElAVISLGGIVhSpSlRVAGDchDEuIlpYlR+pasLlIGEpTAEpIKhEIGoAh.spcsc...ph-l+GRDlloGLP+slplsupElp-ALp-slstIl-u.l+psLEpTPPELuuDIh-+GIlLTGGGALL+GLDchlpccTslPVhlA--PLsCVAhGoGcsL-phctlpp	.............................................................................................................s.pDluIDLG.TA.N..T..L..l....YV...+...G...+.........G...I........V.........L...........s.........E.............P.......SV..VA.lcpc............................sppl..h....AV..G.c......-.....A......K....p....M....l....G.....R....T................P..G....N....I................t.......A.......I......R.........P..............h...............K.............D.......G.......V..........I..............A........D..........F..............p.........l.......T........E.......p..........M....L..p..........a......F.I....c.p.lps..........pp...h.h......s......pP...Rl...llCVPsGsTpVE.+R.AlcE...uA..h..t..A..G..A..R..-.Va.LIEEP..h..AA..A....I..G...A.G....L.....P........V....p....E.....P....s....G....s.....M..VV...DIGGG.TT.EVA..V..I.....S.....L...........G...........G.............l....V.....h.....S.....p.....S.....l.....R......l....uGD......+.h......D....-....A....I.....l....s....Y....l.............R....+....p......Y.............s...........l.........L.......I......G...............E.............p.............T.............A.........E.......c...I........K...h..........c.....I...G.....o......A..h...s...s.....s....c..sc..............ph-...V.....R............G............R............s..........L............s............s............G.............l............P...........+...........s.......h...........s...........l....s....S........s....E.........l...........h....E.A....L.........p.E.sl..s.........t.........I....V.s.A....V.+.s.sLE..p...s......P.........P.....E.....L......A......u.....D.I..h.-.........+........G.........l........VL.TGG.GALL+......sLDclL....t-E.T.....u.......l.....P.V.h.l.A-..-.PLsCVAhGsGcuL-.h-h..pt.................................................................................................................................	0	366	693	848
+6552	PF06724	DUF1206		Domain of Unknown Function (DUF1206)	Yeats C	anon	Yeats C	Family	This region consists of two a pair of transmembrane helices and occurs three times in each of the family member proteins.	22.30	22.30	23.20	22.90	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.23	0.72	-4.22	149	831	2009-01-15 18:05:59	2003-07-30 09:49:12	6	3	248	0	368	915	30	72.50	25	76.68	CHANGED	Rh......GhsupGllahhlGhhs........ltsAh..st......supssutsuultpLhsp.PaGthLLsllulGlluaulaphhcAhhcph	............RhGhsupGllahhluhhs..........lth...Aht...s.......supssstsuultpL....hsp.P.hGphLLhllulGlluhulaphhpAhhtt..........	0	107	231	321
+6553	PF06725	3D		3D domain	Bateman A	anon	Bateman A	Domain	This short presumed domain contains three conserved aspartate residues, hence the name 3D. It has been shown to be part of the catalytic double psi beta barrel domain of MltA [1].	23.80	23.80	24.00	24.20	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.45	0.72	-4.00	41	3329	2012-10-01 21:39:58	2003-07-30 11:02:56	6	38	2021	13	572	2394	113	70.00	40	19.85	CHANGED	polAVDsslIPlGohlalpu.................hthslAtDTGuAIKGs.+lDlahuosscAsp.hG..p+psplalLt	.................h.slAVD.plIP..lGohl..alps........................................ht..hhl.AtDTG.G..AI...K....Gs..+lDlah.Ghs...s........cAsp....h.G...++ps.c.ValL.............................	0	203	382	471
+6554	PF06726	BC10		Bladder cancer-related protein BC10	Wood V, Moxon SJ, Coggill PC	anon	Wood V	Family	This family consists of a series of short proteins of around 90 residues in length. The human protein Swiss:O60629 or BC10 has been implicated in bladder cancer where the transcription of the gene coding for this protein is nearly completely abolished in highly invasive transitional cell carcinomas (TCCs) [1]. The protein is a small globular protein containing two transmembrane helices, and it is a multiply edited transcript.  All the editing sites are found in either the 5'-UTR or the N-terminal section of the protein, which is predicted to be outside the membrane. The three coding edits are all non-synonymous and predicted to encode exposed residues [2]. The function of this family is unknown.	19.60	19.60	20.20	19.80	18.60	17.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.15	0.72	-3.95	11	187	2009-01-15 18:05:59	2003-07-30 12:38:41	7	1	168	0	112	155	0	61.80	41	52.91	CHANGED	MaCL+ahlPlLllPh...s.uhhpAsshFhh.laLluhhlcppPCsaCullhhhhhhs.s..psshssh	.....MaCLp.hhL.PlL.lIPh...p..hh.upshFhh...hall.....uhhl.++PCshCullhLhhhhh.s....ssWus...........	2	23	43	82
+6555	PF06727	DUF1207		Protein of unknown function (DUF1207)	Moxon SJ	anon	Pfam-B_23454 (release 10.0)	Family	This family consists of a number of hypothetical bacterial proteins of around 410 residues in length which seem to be specific to Chlamydia species. The function of this family is unknown.	20.30	20.30	25.20	22.50	15.80	18.40	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.18	0.70	-5.63	8	77	2009-09-11 12:14:12	2003-07-30 13:56:56	6	1	75	0	30	57	13	311.30	36	83.55	CHANGED	+hlcssh.sll.csss..loLPsDplhups..spIsphlp-lPhlTuVEIsE...............pp..sshsptsstsss..cpps.sscs.sshtslWLPpGp.LFpPLlADPRtsp.SAuaR..ascplsGs...+lGuVuFG-slPhhR.sslu+apssh-lGLQuGVFSsFDLDsPSosLlNoDFhVuhhhShtsupaShRhRlYH.SSHLGDEFLLp+..sshsRhNLShEulDLhlSachtP..lRVYGGsGaIhp+-so.sl+PahhchGlELR.uPatl....s.LhucPlFAhch+saEppcashD.ShhhGhEau+FpshG...RKlphllEYapGaS.pGQFhREpscYhGhthpYtF	....................................................................................................................................................................p.t..sh...shhpslaLPp.ss.LFsPLlADPRpsp.SAuhR.....hs-ps.hGp................pluussFGuchhhhR..h-h..upaps..sh-lG....lQG.uVFSsFsL-p.....spu...........sh.VNo.DFhlus.hh.sas.........h....s...........ca...ShRhRlaHlSSHLGD........EF.....l.......Lsp..........Ps.h.p...R........h.N.hScEulDhhsShch........sPp....lRlYGGhGYll...s+...-.o.stcPhhhpuGlElR.....Pash.........ssLcupPlaAh.c...h+....haE-pcashD.o..hhsGhEau.....+hps.lG...RKlRshlEYapGaSpcGQFh+-pssYhGhtlpYsF.........	1	12	16	27
+6556	PF06728	PIG-U		GPI transamidase subunit PIG-U	Wood V, Moxon SJ	anon	Pfam-B_7677 (release 9.0)	Family	Many eukaryotic proteins are anchored to the cell surface via glycosylphosphatidylinositol (GPI), which is posttranslationally attached to the carboxyl-terminus by GPI transamidase. The mammalian GPI transamidase is a complex of at least four subunits, GPI8, GAA1, PIG-S, and PIG-T. PIG-U is thought to represent a fifth subunit in this complex and may be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI [1]. 	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.54	0.70	-5.60	64	358	2012-10-03 03:08:05	2003-07-30 14:05:33	8	7	283	0	247	623	14	321.40	29	81.80	CHANGED	hsuhhlRlhl...hhsshs.phLss+lEl...................STPlsSa+plpE.GhaLhppu.l...........sPYsGul.hH..........psPLlLhlhshl..........................h.............hsllahlhDllsAhhLhth...........................................................thppstpph.tt..t........................hsshhlushYLhNPhslhoslutSTsshsNhhlhhslhsss.p.........sp...............hhhuslslAhuoa.lohYshhLlhPllhhhhp........................................................t.phh.hhhp...hhhlahsslhsLhh.hSah.lsu.......................sas...FlpssYshhlph...p-Ls...PNl..GLaWYFFsEhF-pF+sFFlhlFplhs.hhallP.LolRLpcp...........PhhhhhlhlulhulFK..sYPolu...............DsuhaLuLlslapp.l......................hthh+ash..lss.sshlhshlLuPlhaaLWIhtGoGNANF.FauloLla	.....................................................................................h..shhhRhhl....hhssh.....lstpsEh...................soPlsS..a+p.............l........E.GhhLhp.s...h...........sPYsGsh.hH.........................psPll.l.hhthl............................................................htllahhhDhlsAhhLhhh................................t............................................ptht.....t.........................................................shhluhhYLhNPhsl.h.oC.lu.tS.osshsshhlhhhlhtsh.p...............sp................................shh.uhhhl.uhuoa.hShYPhhLhsPhlhhhhp............................................................................................t.hh...h..hht............hhhhh.h.s.slh.........hlhh...hShh..hhs.......................sap......al.tsYGhhl.h......DLs......PNl...G...La....W...Y....F....F.h....E.....hF....-.p....F....p.........F..F.....lhl...Ft.lph....hha.hhP....Lsl...+h..+cp..................Ph.h.h..hhhhlulhulh...K..sYPolu.....................D...suh...a...huhlslatp...l.........................h..h.h.+..h.....hhh...hhhlh..s.hLhPhhaaLWIhtGouNuNF.aauhoLsa.........................................................................................................................................................	0	91	140	206
+6557	PF06729	CENP-R	NRIF3;	Kinetochore component, CENP-R	Moxon SJ	anon	Pfam-B_23665 (release 10.0)	Family	This family consists of mammalian kinetochore sub-complex proteins CENP-R, also referred to as nuclear receptor co-activator NRIF3 proteins. NRIF3 exhibits a distinct receptor specificity in interacting with and potentiating the activity of only TRs and RXRs but not other examined nuclear receptors. NRIF3 as a co-regulator that possesses both transactivation and transrepression domains and/or functions. Collectively, the NRIF3 family of co-regulators may play dual roles in mediating both positive and negative regulatory effects on gene expression [1]. CENP-R is one of the 15 components that make up the constitutive centromere associated complex (CCAN) part of the kinetochore. A sub-complex of CCAN, consisting of CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step. Kinetochore assembly is a cell cycle regulated multi-step process. The initial step occurs during interphase and involves loading of the 15-subunit constitutive centromere associated complex (CCAN). Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis [2,3].	27.00	27.00	32.30	32.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.65	0.71	-4.51	11	37	2012-10-08 12:26:51	2003-07-30 14:33:12	7	3	28	0	15	54	0	117.50	55	78.39	CHANGED	+K+slssYSPTTGTpQhSPaSSPTSsptQ-h+NGPSNGp...cp.sc.slscRtpspspD.DtFMsLhScV-pS.EcIhElhpNLoSlQALEGSRELENLIGlSpuSChLppEhQKT+cLMoKspK.cLhcKpputlPs+-h	....+KKslhsYSPTTGTpQhS.FuSPoSsccQcHRNG.SNtp..pcp.sc.sLocptpspTc-.DtFhhLhSKVEp..EcIhchhpNLoSlQALEGSRELENlIGlSpsSp.LptEhpKTptLMops.c.pLhc+.pstlPt+t......	0	1	1	5
+6558	PF06730	FAM92	DUF1208;	FAM92 protein	Moxon SJ, Eberhardt R	anon	Pfam-B_23546 (release 10.0)	Family	This family of proteins has a role in embryogenesis. During embryogenesis it is essential for ectoderm and axial mesoderm development [1]. It may regulate cell proliferation and apoptosis [2].	23.60	23.60	23.60	23.90	23.40	23.20	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.59	0.70	-5.01	3	180	2012-10-03 12:17:00	2003-07-30 14:52:42	6	5	78	0	107	155	0	185.00	52	69.77	CHANGED	MhRRs....L-sRDAQTKQLQ-AVoNVEKHFGELCQIFAAYVRKTARLRDKADLLVNEINuYAuTETPNLKL..GLKsFADEFAKLQDYRQAEVERLEAKVVEPLKsYGTIVKMKRDDLKATLTARNREAKQLoQLERTRQRNPSDRHVISQAETELQRAsMDAoRTSRHLEETIsNFE+QKlKDIKsIlSEFITIEMLFHGKALEVaTAAYQNIQNIDEDEDLE	..................................R-sQs+.lpsslsNsEKHFG-hCplFAu.YsRKTARLRDKuD.......LVppl.tsYAsoEs.P.pL+h..GL+sFA-...chAKl.QDYRQAE........VE.RLEuKV.VpPLKtYG..sllK.pR--lKtshpARs+EhKQhppLE+hRQ+sPS.D.Rp.h...I.s..p...AEo-Lp+AshDsoRoo+pLEEs.......lssFE+QKl+DlKpIhu-FlpIEMhFHuKALEVhosAaQslpplD.-cDL..............................	0	23	29	51
+6560	PF06732	Pescadillo_N		Pescadillo N-terminus	Moxon SJ, Wood V	anon	Pfam-B_77615 (release 9.0)	Family	This family represents the N-terminal region of Pescadillo. Pescadillo protein localises to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest [1]. This family is often found in conjunction with a Pfam:PF00533 domain.	25.00	25.00	32.10	32.10	23.40	21.60	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.89	0.70	-5.15	9	361	2009-01-15 18:05:59	2003-07-30 15:27:31	6	7	309	0	244	367	12	258.90	46	46.38	CHANGED	KpKhcpGsAspYlTRppAl+KLQLoLsDFRRLCIlKGIYP+EPK+.KKKsNKGSot.+saYhtKDIpaLhHEPIlpKFR-YKlFh+Klp+Ah.u+t-hpssK+Lhss..+PsYpLDHIIKERYPTFhDALRDlDDALSMlFLFSshPsop+..........lpsphlppC++LssEahpYVhco+uLRKsFlSIKGlYYQAElhGpclTWllPa..tFspshsoDVDF+VMhTFlEFYpsLLuFVNFKLYpsLsLhYPP+l-sphcppttst.uhcht.susphshths.stpttcsh	..........KKhppGpApsYITRspAl+KLQlSLsDFRRLCIhK...........GIYP.REP+p......KKK.ss.KuuosspTaYahKDIpaLhHEPllpKFR-hKsah+Kl.p+Ah.u+s-hssscRLccN........+PpapLDHIlKERYPTFlDALRDLDDsLohlFLFushPs.ssp...................l.sph.lphCpRLshEa.tY.lhts+uLRK....sFlSIKGlYYQApl.......Gp.....p..lhWlsPa..pF..spp.hs..sDVDaRl..MhTFlEFYpT..LLuFVNF+LYps...l..sLh.Y.PPpl-tptpptt..t.thtsh.......h..........................ttt.t.............................................	0	91	139	204
+6561	PF06733	DEAD_2		DEAD_2	Vella Briffa B	anon	Pfam-B_1713 (release 10.0)	Family	This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.63	0.71	-4.86	33	3488	2012-10-05 12:31:09	2003-07-30 16:01:32	10	48	1979	5	1199	2928	287	131.00	24	17.76	CHANGED	YsSRTHoQlpQslcEL++l.thh................hpsls.LuSRcplClpsclpc.tt..tpsls...thCpphtpph...........................C.aapsh.....ph.t....pphhhsslhslE-Lhc......hGcptphCPYass.RchlppA-lllhsYpYLlssphRpth.......lphcsslVIlDEAHNl.csstp...hhShclopppL	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s......h.t..........C........Pa...........h.......h......u....Rc....t......h..............p...AD........VV..lss...ap.h.l.....h.s..s.h..h..t..ctsh....................s.c.s...p......l.l.......l.........hDEAH..pLs-hupp..hhuhsls....................................................	1	423	690	993
+6562	PF06734	UL97		UL97	Vella Briffa B	anon	Pfam-B_1747 (release 10.0)	Family	This family represents a conserved region within viral UL97 phosphotransferases. UL97 participates in the phosphorylation of the nucleoside analog ganciclovir (GCV) to produce GCV-monophosphate [1].	25.00	25.00	43.90	42.60	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.24	0.71	-4.92	8	208	2012-10-02 22:05:25	2003-07-30 16:47:50	7	1	30	0	0	154	0	170.10	60	38.99	CHANGED	NlLIsss.cssppIh+AVLCDYSLSEsHPp.aNcRCVVVFQpT+TlRhlPsSpa+Ls-hYHPAFRPlsLQKllll-P+ApFPss.uspRaCss-LCALGpVlsFCLlRlLDcRGhccVRtssEstLFphAspACcAhtpcclsuhuDAChhlLAcQLuYhusLLG.--ss-hhs+hhcFlcsps-ps	.NVLIcVNPHsPSEIlRAALCDYSLSEPYP-.YN-RCVsVFQETGTARRIPNCoHRLRECYHPAFRPhPLQKLlls.-.P+upFPss.uhpRaChS-LsALGpVluFCLhRlLD.......+RGhcEVRhsoEshLFthAstACRALtptplscsuDAChLlLAtQhuYsAsLLG.-cssslhu+hhcFlEs+hsp.........	0	0	0	0
+6564	PF06736	DUF1211		Protein of unknown function (DUF1211)	Vella Briffa B	anon	Pfam-B_2594 (release 10.0)	Family	This family represents a conserved region within a number of hypothetical proteins of unknown function found in eukaryotes, bacteria and archaea. These may possibly be integral membrane proteins.	25.00	25.00	29.00	25.60	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.05	0.72	-3.84	95	961	2009-01-15 18:05:59	2003-07-30 17:11:10	6	3	572	0	286	777	47	86.70	33	41.94	CHANGED	pRl-AFoDuVhAIhhTllVL.............-l...........................phPp...........sthhpsLh.shhsphhsYllSFlhluhhWhsHHphaphlp..plsptllhhNhhhLhhls..LlP	............................pRl-AFoDuVlAIlhTllVL.............-l...........................phPp...................ssshpuLh..phhsp.hhsYllSFlhluhhWhsHHpl.Fp.hlc..clstpl.hhhNhh..hLhhlohlP...................................	0	97	171	217
+6565	PF06737	Transglycosylas		Transglycosylase-like domain	Bateman A	anon	Bateman A	Domain	This family of proteins are very likely to act as transglycosylase enzymes related to Pfam:PF00062 and Pfam:PF01464. These other families are weakly matched by this family, and include the known active site residues.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.69	0.72	-3.68	18	1273	2012-10-03 00:09:25	2003-07-30 17:12:09	9	31	590	2	302	1024	36	75.60	45	27.18	CHANGED	sAssssWDtlApCESGGNW.ulNTGNGaYGGL.QFstuTWpuhGGspYus.sAstAoRppQIulA-+lhssQGhuAWPsC	..............s..ssssWDt..lApCESGGN.......W.ul.......N.....T.G.....NG.a.....a.GGl.QFstuTWpuhG.G..st.a.t..s....pss....tA........o+........p....pQ....IslAp+lh.......s.s.QG...hG...AWPsC............................................	0	77	214	286
+6566	PF06738	DUF1212		Protein of unknown function (DUF1212)	Vella Briffa B	anon	Pfam-B_1646 (release 10.0)	Family	This family represents a conserved region within a number of hypothetical membrane proteins of unknown function found in eukaryotes, bacteria and archaea.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.05	0.71	-4.84	181	3852	2012-10-02 11:53:07	2003-07-30 17:20:57	7	11	2765	0	655	2941	60	188.90	23	54.74	CHANGED	hGchLlpsGupshRVEcshpclu.pshGl..p.spshhsssulhloh.....ttsspshophppl.pspslshp+lsplpplscpltp..splsl.c-s...ppcLcpIpppt.....Yshhhhs.luhuluuu..uhshL.hGGs..hhchhhuhlsuhl......shhlphh.hs+tphsthhhp.hhuuhlsuh...........................luhhhh........th..shsh.shshh.hhuulhhLlPG	....................................................sGphLLpsGucshRV--shpRlu....p.s.h....G.h....sp..spshlsssuIhhoh...................sspsh.ophpcl..p..s.......pslshp+lsplpplscp..htp.............pp..l..sl..cps.......pp...cLppIptt..p.....Y.s.h.h.hh.s..lusu.lu.s.u..sFshL...h..G..G..s.....hhs.slhshluusl........................uhhlpth.l..s.+h..t..h.h...h.ls.....hl........uuhlssh...........................lu.hhhh......................ph..sh...s....t..s...s.hh...hhuulhhLVPG...........................................................................................................	0	207	396	545
+6567	PF06739	SBBP		Beta-propeller repeat	Yeats C	anon	Yeats C	Repeat	This family is related to Pfam:PF00400 and is  likely to also form a beta-propeller. SBBP stands for Seven Bladed Beta Propeller.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-7.54	0.72	-4.17	52	656	2012-10-05 17:30:42	2003-07-31 09:37:18	6	61	93	0	325	796	561	36.30	30	14.83	CHANGED	tahp..lG.......ssssps..spuIuhDppGN.lYlsGpTsu..sat	...............asp..lG............ss.ss..s......upu....lulD.ss.GN.lYlsGtTsu..sh.........	0	218	271	288
+6568	PF06740	DUF1213		Protein of unknown function (DUF1213)	Vella Briffa B	anon	Pfam-B_2177 (release 10.0)	Family	This family represents a short conserved repeat within Drosophila melanogaster proteins of unknown function. Approximately 50 copies of this repeat are present in each protein.	21.30	21.30	22.20	21.30	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.32	0.72	-3.84	29	411	2009-01-15 18:05:59	2003-07-31 11:07:59	7	12	12	0	314	459	0	29.70	64	20.54	CHANGED	KEsSRPESVsESlKD-s........tcs..cSRhESl	...KEsSRPtSVAESVKDEs............EKo.ttSRRESl..................	0	53	53	203
+6569	PF06741	LsmAD	Ataxin-2-like; Ataxin-2_N; 	LsmAD domain	Vella Briffa B, Bateman A	anon	Pfam-B_2543 (release 10.0)	Domain	This domain is found associated with Lsm domain [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.41	0.72	-3.88	26	396	2009-01-15 18:05:59	2003-07-31 13:05:57	8	12	263	0	244	409	5	70.30	42	7.87	CHANGED	FG.VpSTaDEcL..YTT+L-+uss.pa+ppppcA-+lA+EIEsp.sotshHlt-ERuh..h.s-sshDEE-pYSuVpRs	....aGVpoTYDpsL..YTs.L-+sss.pa+cREtcAsclA+EI...Euo..............sp.Rst.....htscsshs..EE-KYSuVpRp.............	0	77	130	192
+6570	PF06742	DUF1214		Protein of unknown function (DUF1214)	Vella Briffa B, Finn RD	anon	Pfam-B_2721 (release 10.0)	Domain	This family represents the C-terminal region of several hypothetical proteins of unknown function. Family members are mostly bacterial, but a few are also found in eukaryotes and archaea.	25.00	15.00	25.00	15.10	24.90	14.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-11.29	0.72	-3.56	331	1606	2012-10-01 20:00:45	2003-07-31 13:11:51	6	13	655	9	542	1441	270	108.30	21	30.86	CHANGED	ss.t-uhY.hh....st.hDssuph.....lsGst....t.apl......phs.s.thPss........t.FWSloh..Y....stt.......hhts....s....schs.............ls..s..............................ssDG.ohslhlu.s......ss.s.........................N..WL.................t.s................ahlhhRhYt..P.pp	.............................................................ss....tshY..h....s..hDssGp......LsGsp.......t.htl.....phs.s.thPss...........t.FWol..o.h....Ys.pt.h.....hhts.......s.........hsp.hs......lss.....................h..ssDG..olslhlusps..Pss.s...........N.Wl.....h.s.s.......s..hhlhhRhYh..s...tt.............................	0	109	283	416
+6571	PF06743	FAST_1	FAST_Leu-rich;	FAST kinase-like protein, subdomain 1	Vella Briffa B, Fenech M	anon	Pfam-B_2858 (release 10.0)	Family	This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis [1]. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.	24.80	24.80	24.80	25.30	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.09	0.72	-4.26	23	389	2009-09-10 21:09:11	2003-07-31 14:39:19	10	9	79	0	206	364	2	70.70	27	10.78	CHANGED	lssllhsFupLN..YcPsst-pFaspltptLpsphsths..PptllsllaSLshlppaPhshlsplhsssFlscL	.............ltpllhsFupLN..Y....p...P...s.pp.....c.p.Fh.....spltptLtpc..hsths......Ptt....llsllaSLshlpphP..phlptlhsspFlpph.....	0	32	49	104
+6572	PF06744	DUF1215		Protein of unknown function (DUF1215)	Vella Briffa B	anon	Pfam-B_2952 (release 10.0)	Family	This family represents a conserved region situated towards the C-terminal end of several hypothetical bacterial proteins of unknown function. A few members resemble the ImcF protein, which has been proposed [1] to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells line and increased conjugation frequency.	21.00	21.00	21.20	21.00	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.34	0.71	-4.48	111	1351	2009-01-15 18:05:59	2003-07-31 14:55:03	7	9	894	0	251	1140	28	123.70	27	10.91	CHANGED	lpphss........phPsslpshhsplsspuhphlhpsuts.pLsppWpspVhp.appsluGRYPFs.suspDlulsDFschFuss.GhlcpFhpppLtshlc.ssss.Wphcshss..sh.....slssshLpthppAppI	........................................................up........phPsPlpshlsp....lssp........uhphlht.tutp..lspp...Wpss..Vspsap..psluuRYPFs..sospDsols-FpcaFuss.GhlDsFapppLtshl-..ssss..ah.csssst...sh.....slpss.hLsthppAppI......................................	0	35	96	172
+6573	PF06745	KaiC		KaiC	Vella Briffa B	anon	Pfam-B_2234 (release 10.0)	Family	This family represents a conserved region within bacterial and archaeal proteins, most of which are hypothetical. More than one copy is sometimes found in each protein. This family includes KaiC, which is one of the Kai proteins among which direct protein-protein association may be a critical process in the generation of circadian rhythms in cyanobacteria [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.26	0.70	-5.24	26	1953	2012-10-05 12:31:09	2003-07-31 15:32:50	8	20	758	154	980	16013	6155	206.50	22	73.85	CHANGED	lpTGI.GhD-lh.p.............GGlPcspslLloGssGTGKTlhuhQFLhpGhhchGEsGlaVolEEss....psl+cshc.phGWDlpchEccGhlsllDuhsssht............ptslcpLhppLppsl+chsA..+RllIDSlosL..hhppssh.sRphlhpLhphl.cthGsTulhsophs......stpshus.GVEc.slDGlIhLchcchst............chhRolhIhKMRuTsHshpcaPF-Ioc.pGIhlhsttt	......................................................oGl.tlDphl..t............................GG..l...ts..phhL.l....t.G.ss...GoG.K......T..hh....u......h.............p.........F.....l.........h...........p...............u.....h........p........p.............................u.......-............t..............s......l......a...l....s..h.c.....E..s........................tp..l.......h...p.....p..........h.........p.......s..h.......G.......h.........s........h........p.......t........h...................t..........p......t.............l......h....h.h..p.....h..st..............................................ph.p.t..h....h....p..t......l....t..p....t....l....c....p...h....p.s...........p..h.....l..l......l..D.....S....l........ss.........l............................h..........h............t.............s....................t...........t.........h.......+........p..............l........h.....p.......l.......h.....p....h.l.......p......p....h....s......h......o......s.......l...h..s.s...p.h.t................t.t..t..h..s..t..t..l......p.p.......l..s..Ds.l.lhLc....h.....tt..............................phtR....h.lplhKhR.s......s.t..t.t.t......t...h.h.aplsp..tGl.lh...h...........................................................................................................................................................................................................	0	262	574	792
+6574	PF06746	DUF1216		Protein of unknown function (DUF1216)	Vella Briffa B	anon	Pfam-B_3048 (release 10.0)	Family	This family represents a conserved region, within Arabidopsis thaliana proteins, of unknown function. Family members sometimes contain more than one copy.It has been reported that this domain will be found in other Brassicaceae.	19.70	19.70	20.40	19.80	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.93	0.71	-4.39	14	50	2009-01-15 18:05:59	2003-07-31 15:42:00	6	3	5	0	38	49	0	129.60	28	39.42	CHANGED	FFEpLKuhMph.ssh....t.pssKshps-MKupAstLhcAMuuhp....stSuchppplppph.phhKTLp.hp.h.tphh.t..tctcpptohphThpQppElcpslsKWppllopFVcosspspup..ShspSS.........ssssssSS	...........................FFppLKuaMphhsss....t.ssuK.sh.sch+upustLhcAMuuhp.uph.upSuc.ppplppshhphhKTl..h...h.t.h.....hc.cppustphThpQppElhpshsKWppslspFVcosspspup..S.s...uS...t...........s.t......tt........................................................................................................................	0	21	21	21
+6575	PF06747	CHCH		CHCH domain	Westerman BA, Poutsma A, Steegers E, Oudejans CBM, Bateman A	anon	Westerman BA, Poutsma A, Steegers E, Oudejans CBM	Domain	we have identified a conserved motif in the LOC118487 protein that we have called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in common that they contain a predicted conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain). Within each helix of the CHCH domain, there are two cysteines present in a C-X9-C motif. The N-group contains an additional double helix domain, and each helix contains the C-X9-C motif. This family contains a number of characterised proteins: Cox19 protein - a nuclear gene of Saccharomyces cerevisiae, codes for an 11-kDa protein (Cox19p) required for expression of cytochrome oxidase. Because cox19 mutants are able to synthesise the mitochondrial and nuclear gene products of cytochrome oxidase, Cox19p probably functions post-translationally during assembly of the enzyme. Cox19p is present in the cytoplasm and mitochondria, where it exists as a soluble intermembrane protein. This dual location is similar to what was previously reported for Cox17p, a low molecular weight copper protein thought to be required for maturation of the CuA centre of subunit 2 of cytochrome oxidase. Cox19p have four conserved potential metal ligands, these are three cysteines and one histidine. Mrp10 - belongs to the class of yeast mitochondrial ribosomal proteins that are essential for translation [2]. Eukaryotic NADH-ubiquinone oxidoreductase 19 kDa (NDUFA8) subunit [3]. The CHCH domain was previously called DUF657 [4].	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.01	0.72	-3.96	53	994	2012-10-02 15:44:21	2003-07-31 16:10:01	8	11	296	4	623	930	5	35.40	25	22.76	CHANGED	Ctt-hpphhpChppssp...p..hspCpphhpthpp.Chpp	..........CspchcphhsChppssp....p...hppCpct.pshpp.Chh.....	0	169	274	457
+6576	PF06748	DUF1217		Protein of unknown function (DUF1217)	Vella Briffa B	anon	Pfam-B_3199 (release 10.0)	Family	This family represents a conserved region that is found within bacterial proteins, most of which are hypothetical. Some members contain multiple copies.	22.80	22.80	24.60	23.00	21.20	22.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.89	0.71	-4.14	53	429	2009-01-15 18:05:59	2003-07-31 16:22:50	7	6	178	2	178	422	24	141.70	27	69.03	CHANGED	AaGL--.hhs+Ahl+KlLps..shs-ssoaAN+Ls.........Dp.RYpchusAFsFss.t....Gsh................................................sspssstt......................................................................................................................psssspYhppph-ppsGspspulRlALYFpRps.........sslso..................................shclLuss.............sLpphhpTuhGLs.sshushc...l-tQhthlcctl.......phschsD.Pppht	..................................................AaGL-s.thscuhl+KlLps..shsD......s....uhsNpLs.........Dp.RYtphApuFsFssp.Gsh.........................................................................................................................ss..Qopsth.....................................................................................................................pshhstYh........p....p.....s....h..-.p....psus......p.......sp....ss.c...........A.....h.....Yapcph...............sslss..................................s.-lLuDp.............tLhshhhsuhGls.sphst.t....................................p..............................................	0	36	78	108
+6577	PF06749	DUF1218		Protein of unknown function (DUF1218)	Vella Briffa B	anon	Pfam-B_3286 (release 10.0)	Family	This family contains hypothetical plant proteins of unknown function. Family members contain a number of conserved cysteine residues.	21.70	21.70	21.70	22.60	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.12	0.72	-10.31	0.72	-3.53	39	580	2009-01-15 18:05:59	2003-07-31 16:26:16	7	5	148	0	209	417	0	76.60	39	56.25	CHANGED	sAhlhLhhuQllssssstC....hCs...ups.......hhs.ttsp+shulhhhlloWlshslAhshLlsGustNuhpth........................s.sChhl+cGlFuuuAs.......lsLhsslh	...........................................psllhulo+C....hCh.....G+s..............lsP....uusRuhsllhFlsSW.lTF.........llAEuCllAGutp.NAhHs..............................................................................................	0	27	118	166
+6578	PF06750	DiS_P_DiS		Bacterial Peptidase A24 N-terminal domain	Yeats C	anon	Yeats C	Domain	This family is found at the N-terminus of the pre-pilin peptidases (Pfam:PF01478). It's function has not been specifically determined; however some of the family have been characterised as bifunctional ([2]), and this domain may contain the N-methylation activity (EC:2.1.1.-). It consists of an intracellular region between a pair of transmembrane. This region contains an invariant proline and two almost fully conserved disulphide bridges - hence the name DiS-P-DiS. The cysteines have been shown to be essential to the overall function of the enzyme in [1], but their role was incorrectly ascribed. 	23.00	23.00	23.20	23.80	21.90	22.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.27	0.72	-4.19	156	2675	2009-01-15 18:05:59	2003-08-01 09:33:18	8	8	2521	0	532	1905	721	94.00	36	36.27	CHANGED	llG...hhlGSFLNVVlaRlP......tth.......................................slhhP............t.SpCPpCppplpha-sIPllSaLhL+G+.C+tCpstISh+YPllEllsullh...hhshhthuh	............................lhGhhlGSFLsVlIhRlP.......ht.h..............................................................slh.h.P.p.S+CspCpppl+hh-.IPllSa.L.h.L+G+.C......RpCp.spIuhpYsLlElls.u.llh.lhhhhhh..h....................	1	185	349	455
+6579	PF06751	EutB		Ethanolamine ammonia lyase large subunit (EutB)	Moxon SJ	anon	Pfam-B_6325 (release 10.0)	Family	This family consists of several bacterial ethanolamine ammonia lyase large subunit (EutB) proteins (EC:4.3.1.7). Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vicinal amino alcohols to oxo compounds and ammonia. The enzyme is a heterodimer composed of subunits of Mr approximately 55,000 (EutB) and 35,000 (EutC) [1].  	25.00	25.00	31.30	31.10	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.43	0.70	-6.15	12	1141	2009-01-15 18:05:59	2003-08-01 09:56:23	6	3	1070	18	217	709	31	435.60	63	95.67	CHANGED	sYpFcsL+-VhAKAs.t+SGDpLAGlAAsSupERVAA+hlLuclsLpchhpssllPYEpDEVTRlI.Dshstttas.lpphTVu-hR-WLLscpss...ssplptlu.GLTsEMlAAVoKLMpN.DLIhsApKhcVss+hpoTIGlpGphSsRLQPNHPTDDPpGIsASlL-GLhaGsGDAVIGlNPssDossulsclLchh-clhp+acIPTQsCVLuHVTTphEAIcpGsPlDLlFQSIAGoEtuNpuFGlslAlLcEApphuLshpp.ssGsNVMYFETGQGStLSusAHaG.....VDQ.ThEARsYulA++acPhLVNTVVGFIGPEYLYDuKQlIRAGLEDHFhGKLhGlPMGsDlCYTNHhcADQsDh-NLhsLLssAGsNalMGlPsuDDVMLNYQTTuaHDshhlRclhGL+PhsEFEpWLpchGhhtt.sG+Ls.tuGssuhF	.......sYpFcslK-VLAKAs.hRSGDhLAGVAAsSupERVAAK.VLu-hs..............ls-............lhNsPVIsY..E..-DpVTRLI.DshscsAas..p..I+paTlu-LREalLS-c.To.....s.sc..lthlpcGLTsEhVAAVuKlMsNtDLIhuA+Kh.V..lp+hpTTIGl....PGshSsRLQPNcspDDlpuIAAplh-GLsaGsGDAVIGlNPVTDslcsl...s+lLchltslIp+asIP..T..Q..u..CVLAHV..TTQ..IEAI.cR.G.A.PssLlFQSIuGoEKuN.csFGlsL.............A.hL.cEA+tsuhphs.R..............h.......sGp.....NshYFETGQGSALSAsApaG.....sDQ.ThEARsYGlAR.......+a-...............P..............FL.............VNTVVGFIGPEYLYss+QIIRAGLEDHFhGKLhGlsMGCDsCYTNHA-ADQND.-NLhhLLusAGCNaIMGlPhuDDl.........MLNYQTTuFHDshslRplLsLRPuPEFEcWLEpMGIh...s..s.G.+LoppuG-ss................	0	60	124	172
+6580	PF06752	E_Pc_C	E_Pc_C-term; 	Enhancer of Polycomb C-terminus	Vella Briffa B	anon	Pfam-B_16811 (release 10.0)	Family	This family represents the C-terminus of eukaryotic enhancer of polycomb  proteins, which have roles in heterochromatin formation [1]. This family contains several conserved motifs.	19.70	19.70	19.80	20.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.56	0.70	-4.85	5	124	2009-09-11 20:40:39	2003-08-01 10:02:32	7	4	42	0	55	110	0	215.70	53	29.54	CHANGED	uFTAEQYQQHQQQLVLMQKQQLtQLQQpQQsssSosssss......................pulVSKTLDSASAQFAASALVTo-.QLLuhKSKE-sVhtsGVNGVVsuSGsYKuLHl................TsSAlsph..s..SuuSossuPosslsoSsupoossHtlsAhu...........sAosQsLhGNNlpLoVPosluTVssVoPlssRHlsRTLusVPsSALKLAAsANs..pVPKV.TuSSolD.luRENHEsEKPALNuLAENTVAMEVT	.......................uhTtEQaQpHQQQLs.MQ+QQ..LAQlQQp....Qts....ppSSppTp.p..............................shpshhSKTLDSASApFAASAlVou...hhu.thK-pssht..slNGVl.sS.G.......s.KsLa.................TshAL..............uSo.h.sus.h.posuHoshsH.l.sAhs...........ouosQsL.hNN..pLTsssplssVssluPlNs+h.sRT.u.s.s.P.oALKLA..ss..Ass...pVPKV..ssSSu..lsolsRENHEsE+.uLNsIA-sTVAMEVT......................................	0	3	8	22
+6581	PF06753	Bradykinin		Bradykinin	Moxon SJ	anon	Pfam-B_7085 (release 10.0)	Family	This family consists of several bradykinin sequences. The skins of anuran amphibians, in addition to mucus glands, contain highly specialised poison glands, which, in reaction to stress or attack, exude a complex noxious cocktail of biologically active molecules. These secretions often contain a plethora of peptides among which bradykinin or structural variants have been identified [1].	20.70	20.70	20.90	20.90	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.55	0.72	-6.57	0.72	-4.36	2	35	2009-12-03 16:03:04	2003-08-01 10:06:19	7	5	8	0	0	37	0	16.50	85	34.95	CHANGED	LQRRPsGFTPFRGKFHSQS	s...RPPGFSPFRGKFHSQS..	0	0	0	0
+6582	PF06754	PhnG		Phosphonate metabolism protein PhnG	Moxon SJ	anon	Pfam-B_6667 (release 10.0)	Family	This family consists of several bacterial phosphonate metabolism protein PhnG sequences. In Escherichia coli, the phn operon encodes proteins responsible for the uptake and breakdown of phosphonates. The exact function of PhnG is unknown, however it is thought likely that along with six other proteins PhnG makes up the the C-P (carbon-phosphorus) lyase [1].	25.00	25.00	26.20	26.20	23.70	22.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.69	0.71	-4.58	50	665	2009-01-15 18:05:59	2003-08-01 10:41:11	7	3	645	0	125	413	78	145.30	51	96.70	CHANGED	sshssRptWMulLA+A.....ssscLsshhsslsh....PsaphLRsPEsGhVMVRGRhGGoGusFNLGEhTVTRssV+Lss.....Gp..lGauYlhGRD+p+AElAAlhDALhQpsstt.......splpppllsPLttttsspctp+AAcsAATKVDFFTM..VRGED	...........................s.pAsRQ+WMuVLA+o.....pss....ELsA+hpA.L.sl....sssYclIRAsEoGLV.lpuRMGGTGcp.FhhG-sTlTRAuVRLsD..............................GT....l..GYSaVLGRDKpHAEtsALlD.ALhQps...c.ph.......psLpcsL..IsPLcAcphsRhAs...RpAE...lsAoRVDFFTM..VRG-s....................	0	22	66	91
+6583	PF06755	DUF1219		Protein of unknown function (DUF1219)	Moxon SJ	anon	Pfam-B_4928 (release 10.0)	Family	This family consists of several hypothetical proteins which seem to be specific to the Enterobacteria Escherichia coli and Shigella flexneri. Family members are often known as YeeV proteins and are around 125 residues in length. The function of this family is unknown.	25.00	25.00	28.30	25.80	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.38	0.71	-4.57	8	829	2009-01-15 18:05:59	2003-08-01 10:48:13	7	4	345	0	38	369	4	110.90	74	90.28	CHANGED	MpT.PssssptApsCPSPVsIWQpLLoaLL-QHYGLTLNDTPFuDEsVIpEHI-AGISLsDAVNFLVEKYsLVRIDRcGFSsppQSPhloulDILRAR+ATGLhppps..sl.........tt+	..................MKTLPsohsRtASpCPSPV.sIWQpLLoRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGFSsss.pSQLINSIDILRARRATGLMTRcNYRTVN.sIThG+ast.....................	0	3	8	21
+6584	PF06756	S19	S19_C-term; 	Chorion protein S19 C-terminal	Vella Briffa B	anon	Pfam-B_16839 (release 10.0)	Family	This family represents the C-terminal region of eukaryotic chorion protein S19. In Drosophilidae, the S19 gene is known to form part of an autosomal cluster that also contains s16, s15 and s18 [1]. Note that members of this family contain a conserved PVA motif, and many contain Pfam:PF03964.	25.00	25.00	110.80	110.00	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.76	0.72	-4.12	6	18	2009-01-15 18:05:59	2003-08-01 11:00:52	6	2	14	0	8	21	0	76.80	66	38.58	CHANGED	uuss.uGsYGGt....huPRaTVQPAGsTLLYPGQNSY+sYsSPsEYSKVlLPVRAAuPVAKLYlPEN...sYGupsGY	..............tuh..uGNYGtR.tGhhuPRWTVQPAGATLLYPGQNsYRsYVSPPEYSKVlLPVRsAuPVAKLYlPEN...pYGsQhs..........................	0	1	1	4
+6585	PF06757	Ins_allergen_rp		Insect allergen related repeat, nitrile-specifier detoxification	Moxon SJ	anon	Pfam-B_5947 (release 10.0)	Family	This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain [3].	21.60	21.60	21.60	22.70	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.95	0.71	-4.79	38	335	2009-01-15 18:05:59	2003-08-01 11:05:02	8	5	49	0	131	369	0	174.00	23	79.51	CHANGED	stsLpsDhp-Fl.sLlPhcp....ltplstcYhhsDschppslpYLpos-Fpplapplhs.hs-lpshlpalc..spGlslhs.......hlNplsshl...sls.l..........pPp.hh............pstulsuhlc-llulLPhcclpALap-Khps.os-Fpthactlpo.-Fpplhppht....ssp-lppllpcL+.cpGl...Dlcpllchl	....................................shptchp-Fh.slls..hcp....l.plhtpYhhpDschppslpal.pss.p...F..tphhpplts.hP-hp.slhsalp...ppslslst...........hl..cplpph.l.....th.ph......................s.s..hp......................pspshpsals-slslLP..hsplpuL..apcK.hps.sstFpphhcslpop-acplhpslh....pscphpslhppLp.ppul...clchlhp..h....................	0	31	38	108
+6586	PF06758	DUF1220		Repeat of unknown function (DUF1220)	Moxon SJ	anon	Pfam-B_6292 (release 10.0)	Domain	\N	20.30	20.30	20.60	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-9.07	0.72	-4.17	15	961	2009-10-27 09:18:29	2003-08-01 11:14:26	8	17	26	0	206	961	0	64.40	48	40.55	CHANGED	EE..-QpPssPRLs.....tEL.-sEE.EVLQDSLDcChoTsSshh-ls-SsQPYcSsFaohEEpcVuhALsVD	...................EE..-QsPssPRLS....................pELh-scEs.EVLQD...SLDcCYSTPSshhEhsDSsQP.YpSs.ha.o...LEEpcVuhuLDls................	0	156	156	156
+6588	PF06760	DUF1221		Protein of unknown function (DUF1221)	Vella Briffa B	anon	Pfam-B_16837 (release 10.0)	Family	This is a family of plant proteins, most of which are hypothetical and of unknown function. All members contain the Pfam:PF00069 domain, suggesting that they may possess kinase activity.	25.00	25.00	91.50	32.80	24.10	23.30	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.45	0.70	-5.09	5	29	2009-01-15 18:05:59	2003-08-01 13:54:25	6	3	13	0	22	30	0	205.70	50	30.18	CHANGED	+DDIp.INQRQCsLLLDlauLAacoVAsElRuNLRF-EKpTKWKsLEQPLRELHRVFREGEAYVRpC..LDPK.cWWAKAIshapNTDCVEaHIHNLLsCluVVlEAIEsAGElSGhDPDEluR+RLVaSRKYDK-WpDPKLFpWRFGKpYLVo+DlCuRhDpAW+EDRWlLlptLQEKKsSuSs...sLoKpE+RLADLLhKsL.ss.p..sGKLaPSSlLLGSKD	.......pD-lp.IN.RQCsLLh-hhshAapslutElRtpL+h-E+t.TKW+sLEpPLRELaRlh+-GEhYVRpC..L.-s+..s......WWu+Ahshppsp-CVEaHlHNLLhChslVlEAIEsAG.El.oG..D.-Eht.R.+RLlhucKYD.+-h.DP+LFp.a+FGKpYLloc-lssRh-tAW+EDRWlLhphlcE++tsuu........loKpE+RLADlLhtth..............GK.LaPuSlLlso.......	0	2	11	17
+6589	PF06761	IcmF-related	ImcF-related; 	Intracellular multiplication and human macrophage-killing	Vella Briffa B	anon	Pfam-B_3476 (release 10.0)	Family	This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed [1] to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.	20.20	20.20	20.30	21.30	19.50	20.10	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.89	0.70	-5.13	95	1440	2009-09-11 20:39:52	2003-08-01 16:13:50	7	11	892	0	268	1260	33	297.20	22	27.04	CHANGED	llssLsslpphstths....sssshhh.chGLapusplssssppsYpptLpphllPtlhpplpppLpssh.....................psscthYpsL+sYLMLs.cts...c.hcsshlpsahtp....pWp.pphsss....ht....pptLttHLstlh.............pts.tshshsssLlppARphLsph....shspRlYpplcpph...spthschsLsctsGss..........sstlF...........pppsspshtt.s..lPGlaTtpGacphFhsplsphspphtp-p.WVL.Gpt....t...sthsssshp........pLtpclpphYhsDYsspWcshLsslclt......shss........lspuhphLpsLuus.sSPLhpLlpslscpTpL	.............................................................hLs.lpp.h.t.tht..h..ctsshhh.chGLYpuppltststpsYhphL...pph...hLPslhppltptLpss.....................................................................ssscpthssL+sYlMLs...c......p........p..hs...s.thlp...pahtp..............pWp..p..phssp..............ht....pptlhtHlpthh..............................pts.....h.p.sp...plltps+p..Ltph....shtpRlYpp.lttp.h......st.............t.s....shsLtchl.Gss..........hstlF..............tptss.............lPshaT+pGapphh.tphpp.hsp.tttt-s.WVLsptt.............p...sh.sps.shp.................plppplpphYhsDYsspWpshlsslplp........shss........lspshp.hLphlsss.suPlhpLhpsltcpTp.....................................................................	0	40	100	180
+6590	PF06762	LMF1	DUF1222;	Lipase maturation factor	Vella Briffa B, Eberhardt R	anon	Pfam-B_3454 (release 10.0)	Family	This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states [1,2]. The precise role of LMF1 in lipase folding has yet to be determined [3].	29.30	29.30	29.90	32.70	28.90	29.20	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.42	0.70	-5.67	25	402	2012-10-02 13:32:46	2003-08-01 16:39:26	9	7	240	0	234	358	72	338.00	35	69.50	CHANGED	auFtW-uLLLEsGFLulFLuPs................psssstlslaLhRWLlFRlhFGuGllKl.R........ssssW+-LTuLpYHaETQPhPsPlSaahHpLPchh++hpssusahsElllPaLlFsP.p.lphhuuslhlshQlhllloGNauFhNaLTllL...................shuslD.......DshLshl.hst......................................................................................................................................p.ss.t..........................................................................sss.sshhhhhlslhlslhlhsLSh........hslhshlstc......Qh..............................................................................................................................................................................Mppsh.ssa+lVNoYGuFuslT..+pR.ElllEGot-st.......ssWc.....................................EYEF+sKPGslpR........hPphluP.YH.RLDWhMWFAAhsstp...............................................tssWhhsFlt+LLps-ps.......sLsLLtcs....PF.sspP.......P.palRAphY..cY+Fosh.pchtpsGt........WWpRphlt.pahPslsLss	..................................................................................................................................................................h.FtW-shLLEsGFLslhl.us........................ths...ss.hlshh.hhRWLlFRl.hu.....u.GllKh.p........ts.sWh..sLTsh....aHaETQPhPsPhuaahH.p.h...Ph..h++hpshus...ahhpl..slPhh.hFhP..............p..ht..........hhuhhh.llhQl..hllhoGNasahNhLTlll...................shuhhD.......st.h...thh..hs..................................................................................................................................................................................................................................................................................................................................................................................................................................................h...s.hhht.hls.hhhthh..lhhlsh............ss..hshhu.p................p...................................................................................................................................................................................................................................................................h..ptsh.s.hplsNoYGh.Ftphs..................ptR.ElllEGotss..t................s.Wp.....................................-YEFhhKPG.s.pR........hP....huP.ap.RLD.W.MWFAAh.ssh........................................................ttsWhhthh.+LLp...sc.t.......sl.pLltp..s.....PF..p.pP..........P.palRuphYpYpFop....tt...tptt.......................WWhRphh.t.ahPsht...p.......................................................................................................	0	97	133	191
+6591	PF06763	Minor_tail_Z		Prophage minor tail protein Z (GPZ)	Moxon SJ	anon	Pfam-B_6085 (release 10.0)	Family	This family consists of several prophage minor tail protein Z like sequences from Escherichia coli, Salmonella typhimurium and Lambda-like bacteriophages.	20.00	20.00	20.10	20.00	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.25	0.71	-4.65	8	914	2012-10-01 22:58:23	2003-08-04 11:55:40	6	3	408	0	33	448	7	176.00	56	97.65	CHANGED	lKGLEpAIcNLsulD+phVPpASAhAlNRVAppAlStosppVA+ET........ulPhKLV+pRsRLp+Aosc.KspA+I+VNRGNLPAIKLGoApVRLS+R.....G.tu.h.htGSVL+lGpaRFpcAFIQQLsNGRWHVMcRlsG..............KsRYPIDVVKIPlAuPLTpAF-pphcRlhcp-hPKpLtaALppQLRLhLpR	...................................................................................lKGL-pAlcNLspls..+pAVPtAoAhAINRVAssAIupousQVARET........tV..RKLV+cRsR..L...p.+Aosc....pspAR.IhV.N..RG...sLPsI.K..LGps.....hhs.pR..............G......ptss.Sl..Lh.l.Gp+.R.h.sAFI.Q..p...L.t.NG....R.WHVMQRlsG......................KNRYP.I.DV....V.K...IP.hAs..P..L.spA..Fcpsh-...RI...h+EcLPKpLuYALppQLRhslKR.......................................................................................................	0	6	13	21
+6592	PF06764	DUF1223		Protein of unknown function (DUF1223)	Moxon SJ	anon	Pfam-B_6655 (release 10.0)	Family	This family consists of several hypothetical proteins of around 250 residues in length which are found in both plants and bacteria. The function of this family is unknown.	26.80	26.80	27.00	30.40	25.70	26.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.31	0.71	-4.50	72	362	2009-01-15 18:05:59	2003-08-04 12:34:50	6	3	322	1	146	334	61	196.70	33	76.90	CHANGED	VVELFTSQGCSSCPPADphLuc...Lupc.............s.sVlsLuhHVDYWDYlGW+DsFupstaTpRQ+uYuptt..stptlYTPQhllsGppphsGsctspltstlptttst....htlslphs..ts.t.plplpssssssht.........hplhlshass.ttssplp+GENtG+plsasNlVpshptl...utWsG.ts.shphsh....shsstts............tssVhlQp	...................VVELaTSQGCoSCP.PADphluclusc..............s.sVlsLuaHVDYWDY.lGW+DsaAsppaTpRQpuYs....p..th..stctlYTPQhllsGpsp........hsGsstssltstlsssttp.....sslslphp..tps...s..plslslssst.tst................tshclhlshaps.shssp.lpcGENtG+slsapplVpshppl...uhWsG....tshph.p.lsh..s...tt.ts...........usslhlQ..........................................	0	36	85	111
+6594	PF06766	Hydrophobin_2		Fungal hydrophobin	Vella Briffa B	anon	Pfam-B_3587 (release 10.0)	Family	This is a family of fungal hydrophobins that seems to be restricted to ascomycetes. These are small, moderately hydrophobic extracellular proteins that have eight cysteine residues arranged in a strictly conserved motif. Hydrophobins are generally found on the outer surface of conidia and of the hyphal wall, and may be involved in mediating contact and communication between the fungus and its environment [1]. Note that some family members contain multiple copies.	21.20	21.20	21.40	26.10	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.96	0.72	-4.29	45	136	2009-01-15 18:05:59	2003-08-04 13:34:33	6	3	55	24	75	116	0	64.80	45	56.32	CHANGED	hCP.uG.Laus.PQCCuosVLGlAsLDCpsPsssssssssFpshCAut.GppspCCslP.lsGQulLCpsP	..............Cs.uG..Laus.PQCCuTDVLG.lAsLDCtsPspssssussFpshCAsh.Gp.p.ApCCslP.lh....GQulLCpss.............	1	9	33	59
+6595	PF06767	Sif		Sif protein	Moxon SJ	anon	Pfam-B_7884 (release 10.0)	Family	This family consists of several SifA and SifB and SseJ proteins which seem to be specific to the Salmonella species. SifA, SifB and SseJ have been demonstrated to localise to the Salmonella-containing vacuole (SCV) and to Salmonella-induced filaments (Sifs). Trafficking of SseJ and SifB away from the SCV requires the SPI-2 effector SifA. SseJ trafficking away from the SCV along Sifs is unnecessary for its virulence function [1].	27.60	27.60	28.20	28.40	26.90	27.50	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.16	0.70	-5.67	4	347	2009-01-15 18:05:59	2003-08-04 13:38:12	6	5	122	2	7	127	0	249.90	46	72.77	CHANGED	MPITIGNGaLKSEIhIsPPupT+EsWWKlLWE+lKDaFFSTG+AKADShlHEMLFuDsPPTRERLs-IFFELKALACASH+DRFQVYNPHEsDuTIIaRIhDENtcsELLRITQsTDTFSCclMGcsYFLh+-pPslLKSaPQMThTINKRYSElV-.sLPSTLCLpLAGsPhLSVPLcNI.tYLYSEhcKsNLDEWKsQEKssYLAsKIpSGIEKsh+hLpHANISESTQQpAFLETMoMCGLKslETsPP.THIPI.KhVcEVLLADKtFpsFLsoDsssSQSMLAEIIEsISDpVF+ALFRhDPQAIQKMAEEQLTTLHlRuppQpGs.LCCFL	...................MPITIG.pGaLKSEIh...opssp...soKES...a...a...pl.LWEKIK...DFFFoTt+AcADpCI+ELh.a.spp.sPTspRL..p-lFhcL+ELASsSCR-pFpl.s.casDspI..Ihp..h.D.pN.sEN...LpIh.ppDta.h-lMsphhhhhcs.psshLK.a....sphshhhpphhs....E.lsh.hPppL.Ls.uGu.h...hsVsLcNIcthLhs.hcKGpLstWKtQE+hshluu+Ip.GItps......ssIs-uhppph.hhcsht.ssLKphth.ssasp.slpphV.psLhtschh.shL.pss...Sts..hLs-lhEhlu.pVapulFp.s.p...................................pp.......................	0	0	0	3
+6597	PF06769	Plasmid_Txe	DUF1224; 	Plasmid encoded toxin Txe	Moxon SJ, Mistry J	anon	Pfam-B_7662 (release 10.0)	Family	The plasmid encoded Axe-Txe proteins in Enterococcus faecium act as an antitoxin-toxin pair.  When the plasmid is lost, the antitoxin (Axe) is degraded relatively quickly by host enzymes. This allows the toxin to interact with its intracellular target, thus killing the cell or impeding cell growth [1]. This family contains many hypothetical proteins. This domain forms complexes with Axe antitoxins containing Pfam:PF02604.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.69	0.72	-4.16	13	1544	2012-10-03 00:18:00	2003-08-04 13:57:46	8	6	1142	20	262	983	101	78.40	41	89.94	CHANGED	FTp-uW-DYhaWQpsD+Khlc+IN+LIc-spRs.PFcGIGKPEPLKtcLoGaWSRRIscEHRLVYhls....DsplsllusRYHY	...................................as.puapD.Yh.aW..p.p.p.D.+.+.h.l.K+Isc....LIc-.lp...R.s......P..a.p......G...h..G.KPEsL...K.t.s.Ls..G.h...WS.RRIs.cc.HRLVY.p..V..s.....-..c...p...l..h..I..h..us+h.HY.....................................	0	87	185	230
+6598	PF06770	Arif-1		Actin-rearrangement-inducing factor (Arif-1)	Moxon SJ	anon	Pfam-B_6086 (release 10.0)	Family	This family consists of several Nucleopolyhedrovirus actin-rearrangement-inducing factor (Arif-1) proteins. In response to Autographa californica multicapsid nuclear polyhedrosis virus (AcMNPV) infection, a sequential rearrangement of the actin cytoskeleton occurs this is induced by Arif-1 [1]. Arif-1 is tyrosine phosphorylated and is located at the plasma membrane as a component of the actin rearrangement-inducing complex [2].	21.10	21.10	22.30	22.00	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.80	0.71	-11.43	0.71	-4.94	17	37	2009-01-15 18:05:59	2003-08-04 14:04:58	6	1	34	0	1	39	0	193.90	30	63.07	CHANGED	hsplhhhV...........hulhGslsp+aAlLl-hE.sspuVhNhShl.shlaGshlhhssshshhthh......tchp.........pshYhpshlsllshhshlphhlFlsh.s.lhc.GHlPsLDshhRcYDpcSlCWsGls......htDsNul..........sp..NChhh........shh..hhCltCRhEhhpcEPThhpppphslhhhslhllllpsashal.hcchpp	.........hhhh......h....hshhshlhulhGhhsscaAlLl-hE.sspuVhNhSsh.hhsaGhhlhhsshhsl..hh...............sphp......pshYhthhhhlhsslshlphhlalsh.shlhc.GHlPsLDVhhRcYDh-uhCWsGIV.....hhDsNsI.........hsp..NChhh........shhhhCstCRt.hhpsEsThhpppphslhhhlhhlhslpsasLah.hpchh.t..........	2	1	1	1
+6599	PF06771	Desmo_N	1111; Desmo_N-term; 	Viral Desmoplakin N-terminus	Vella Briffa B	anon	Pfam-B_3693 (release 10.0)	Family	This family represents the N-terminus of viral desmoplakin. Desmoplakin is a component of mature desmosomes, which are the main adhesive junctions in epithelia and cardiac muscle. Desmoplakin is also essential for the maturation of adherens junctions [1]. Note that many family members are hypothetical.	25.00	25.00	74.70	73.50	23.40	18.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.99	0.72	-4.06	20	59	2009-01-15 18:05:59	2003-08-04 14:20:02	6	1	52	0	0	60	0	86.30	44	11.83	CHANGED	+Y+GsDVs....spTVpNLL+TIsohSpps+s..ssss-hlp+IRsIIlhaRPsLpp.p.scLs.sscLllcuLps..sss.......+pI...THNaNYKYDYN	....+YtssDVs....spTVpsLLpTINoMSpRsKs..sss-chLp+IRsIIlhaRPpLps.+.hDLp.lPpLlhpuLts..sss.......ppI...THNaNYKYDYN...	0	0	0	0
+6600	PF06772	LtrA		Bacterial low temperature requirement A protein (LtrA)	Moxon SJ	anon	Pfam-B_8368 (release 10.0)	Family	This family consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes [1].	21.60	21.60	21.70	21.90	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.01	0.70	-5.54	9	969	2009-01-15 18:05:59	2003-08-04 14:56:32	6	11	713	0	309	814	19	321.40	22	81.25	CHANGED	pc+so.hELFFDLlFVhAlsQlo+tLhpshshstus.....phllhhhulWWsWhppoahsNhhss-ph.sRlhhhs.MhhsllLusulstsF.....psps.hhFsluYshMplupul.aLhAs+.ttshusppshhplushlhluulhWlsuuLh...tstRhhlahlulsl-hhsPh.......hstpshcph.lchtHlAERhuLhsIIsLGEol....lslssshhphshshtshhhhh.uFlsslshWhlYFtpstptss++tpssu.......hhasYuHl.IsuuIhlhuVu.-hslppshscshhtthh.....huusllFLhGhhhhptshtttthss+hlshshL......hLhsshLsshhlpshssllhlsVAhh.hss	....................................................................................pps.shhELFFDLlFV..h....Al....s....p..hsph...lhpt.st.h.h...........pallhhhhlWhhWhtpohasNta..sp.s.....s...h...h..hh...h...h...hhp...M...hh..hl...hh....u...s...u......l.....s.........s..a................................ppph......hh.F...h....l.........s....h..s..h.h..pls.h.sh.p.a......l...h.t....h...p......hs..s.t..c....t...s..h.....h..t....hs..h..h.h...h.l.s..s.h..h....h..h........hu..h....h...h..s.........tth....p.......h....h...h..h...h..l...u..l...h...l.p...h..h.s.sh.....................................ht..p..h..h....t...h.h......s...l...p.h....Hls..ERhuLhsIIhh....G...Esl...................l....u.ls...s....s.....h....h.......t........h.....s.....h...............h.....h.....h.....h.....h.......th.....h.....l.....hhs......lahh...Y.a.....s.....p...p.h..h.s..c..p.h.p.p..ts...............hhh.hY.s.H.h.lh.........hu.l..hh...hs.su.h.t...h...h...........t.......t........h......t.....t....h............h............h...h........................hhu.hh...l.a..hh....u..hh...hhh....h.......h..t...h...........p..hh....hh...........hhhh...h.l..............h......h...........................h....................................................................................................................	0	85	174	256
+6601	PF06773	Bim_N		Bim protein N-terminus	Moxon SJ	anon	Pfam-B_8427 (release 10.0)	Family	This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death [1].	19.10	19.10	19.90	44.30	18.40	16.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.97	0.72	-4.21	2	63	2009-01-15 18:05:59	2003-08-04 15:02:05	6	2	30	0	17	67	0	37.00	90	23.84	CHANGED	QPSslSs-Csp.EGGQLQsspR..phRP...GAPTSLpo..	QPSDVSSECDR.EGtQLQPAE...R..PPQLRP...GAPTSLQTEP.	0	1	1	4
+6603	PF06775	Seipin	DUF1226; 	Putative adipose-regulatory protein (Seipin)	Moxon SJ, Coggill P	anon	Pfam-B_8703 (release 10.0)	Family	Seipin is a protein of approximately 400 residues, in humans, which is the product of a gene homologous to the murine guanine nucleotide-binding protein (G protein) gamma-3 linked gene.  This gene is implicated in the regulation of body fat distribution and insulin resistance and particularly in the auto-immune disease Berardinelli-Seip congenital lipodystrophy type 2. Seipin has no similarity with other known proteins or consensus motifs that might predict its function, but it is predicted to contain two transmembrane domains at residues 28-49 and 237-258, in human, and a third transmembrane domain might be present at residues 155-173. Seipin may also be implicated in Silver spastic paraplegia syndrome and distal hereditary motor neuropathy type V [1].	19.20	19.20	19.70	19.20	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.08	0.71	-4.80	30	347	2009-01-15 18:05:59	2003-08-04 15:05:20	9	9	225	0	212	337	0	188.80	26	50.23	CHANGED	shhhllhlu....lhhY..........ssaYYsalPp..lshpcslahpassss...................PhAplsls.........................tphlhs....sQsYclslcLchP-SshNh..plGhFhVslsh...............................hopsups..................ls.............posRsshLpYcSshlchhpolhhhPhalhGhp.......cEpQplpVphhp..ca.cs............tsPssu.................................................lplplps+p........hQlYsA.pLplpAchsGlRalhYsa.lhShlVhsssha	.................................................................s..hhlhhhu....hhha.h.hY.htahPp...lth.pslahp....appsp..............................PhApssls......................................................................................................................tphlhh........sQsY..clslpLph.PcSshNt......plGh...Fhl.shph...........................................................................hstssph..........................................ls............posRssh........LpYc..Sshlphhps.hhh...s.....hhlhGht.......pppp.hlplphhp....ph...p...t..........................ssss.................................................hhlplpspt................hpl.YsA.plplpAchsGl.R........hlhapa.hhoh.hlhh......................................................................................................	1	72	124	175
+6604	PF06776	IalB		Invasion associated locus B (IalB) protein	Moxon SJ	anon	Pfam-B_3703 (release 10.0)	Family	This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is upregulated in response to environmental cues signaling vector-to-host transmission. Such environmental cues would include, but not be limited to, temperature, pH, oxidative stress, and haemin limitation. It is also thought that IalB would aide B. bacilliformis survival under stress-inducing environmental conditions [1]. The role of this protein in other bacterial species is unknown.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.30	84	752	2009-01-15 18:05:59	2003-08-04 15:18:53	7	2	278	12	212	542	263	127.70	25	66.93	CHANGED	ausWsltCtpstt..spp............CplhQ.ltsp.psphlhphslhphss.....t.sssh..hplhlPhGhhLssGlslplD......ssp.stp..hsashChs.....sGChApls.lssshlsth+...pGspsslshhssss........ps.lslslo.L....pGFssAhcsls	............................................................................................tsWphhCsptt.....spp...............CthhQplhs....p......p.s...ph..s.hs..h.slhphts................t.tphhhhl.hhPhGhhlssGltlplD.................stp.hhp.....htas.hChs.....suChApss.lss.cllssl+...pG.p.s.hslphhssss........ps..lshsls.L......pG.FutAhssh................	0	35	108	144
+6605	PF06777	DUF1227		Protein of unknown function (DUF1227)	Vella Briffa B	anon	Pfam-B_3660 (release 10.0)	Family	This family represents a conserved region within a number of eukaryotic DNA repair helicases (EC:3.6.1.-).	20.30	20.30	21.20	22.70	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.68	0.71	-4.50	30	339	2009-01-15 18:05:59	2003-08-04 15:21:32	6	14	283	0	228	329	6	141.90	50	19.11	CHANGED	pplpclKpsDpp+Lp-EYc+LVcGLcpus..scp.t-.hhss....PVLP--...lL.........cEAV.PGNIR+AEHFluFL+RhlEYLKsRl.......+lp+VlsE.......................oPhoFLp+lcc.................pstI-pKsLRFCuERLpsLlpTLcIsclc-assLphlAsFATLVuTYpcG	..............................p.plpchKpsDtp+LpsEYp+LV-GL......+pAs....s...Rp....pDthhuN..............PlLP-D...lL.............pE.AV.PGNIRpAEHFluFL+RhlEYLKs.Rh.........+VpHVlpE..................................oPsuFLpclpp.................hshI-+KPLRFCuERLpSLl+TLE.....ls....-.lpD.assLp.lAsFATLVuTYp+G................................................................................	0	80	129	194
+6606	PF06778	Chlor_dismutase		Chlorite dismutase	Vella Briffa B	anon	Pfam-B_3770 (release 10.0)	Family	This family contains chlorite dismutase enzymes of bacterial and archaeal origin. This enzyme catalyses the disproportionation of chlorite into chloride and oxygen [1]. Note that many family members are hypothetical proteins.	25.00	25.00	26.10	25.80	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.27	0.71	-4.60	15	1117	2012-10-02 00:20:33	2003-08-04 15:31:48	7	6	979	83	232	766	77	187.80	35	69.25	CHANGED	--RpuhlsEhpsh.hpph...pcptcus.tslYslsGh+AD..lhlahhppsh-cLpplpscFp+op.luchshssaShlSlhc.SsYhs..............psclpupLhsclP...t+YlshYPMsKsh....sWYhLPhE-RcclMc-HGhhu+sassc..V+phhosShGlsDaEWsVsa-ucDltpapclVpchRhsEApp+hsc.tsPFhlG	........................................................................................pRtthhp-htphhpph.........tpp.ppss.puhYslsG.+AD..lhlahht......shcp.Lpph.scF.p+op....lu..ca.h.P..saShVulhc.upYht..................................sal..ApLhs.chP.....sca..lshYPhsKpt.....sWYhLs.EERp+hht...-...H...GhhG.Rp.Yss......V+p.hsuShuh..s...D...aE...Whlsh.u..-..-.lh..p..hhclhh-hRhsEspt.+.ht-..ssFasG.................	0	88	169	216
+6607	PF06779	DUF1228		Protein of unknown function (DUF1228)	Vella Briffa B	anon	Pfam-B_5646 (release 10.0)	Family	This family represents the N-terminus of several putative bacterial membrane proteins, which may be sugar transporters. Note that many family members are hypothetical proteins.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.84	0.72	-3.96	12	952	2012-10-03 03:33:39	2003-08-04 16:37:05	9	2	879	0	193	2042	466	85.10	42	22.01	CHANGED	sluMGlGRFsaTPlLPsMht-tthohusuualAoANYhGYLsGAlhAuhuhtt..up.RhhlhuGhhAoslLhhuMuhhsuhhshhl	................................luMGlGRFhYT.....P..hLPlMh....A.....-....s.....t..h.....o..h..sphua.lASuNY.sGYLsG.u.Ll.hu.hu...thc.........sc.h.+...h.L...h...s...uh...l.A...o..u..l..L.h..Lu.M.A.h.h.sshhlh......................................	0	27	80	135
+6608	PF06780	Erp_C	Erp_C-term; 	Erp protein C-terminus	Vella Briffa B	anon	Pfam-B_4561 (release 10.0)	Family	This family represents the C-terminus of bacterial Erp proteins that seem to be specific to Borrelia burgdorferi (a causative agent of Lyme disease). Borrelia Erp proteins are particularly heterogeneous, which might enable them to interact with a wide variety of host components [1].	22.80	22.80	22.90	28.60	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.10	0.71	-4.35	12	100	2009-12-15 09:40:32	2003-08-04 17:05:26	6	2	23	0	5	82	0	136.90	47	40.69	CHANGED	I+sLscKIDcINpDIDuIpspoo.........Vuuc-VhDKITGPlYDcFTDss...suIYpsW..ssLEp-.E-ptLt+LLcELp-sRssLRoKLNEuNp.h....htpsEPpLK-sVsVS-IKpDLEKLKSpLE-VKcYLcspsNFEEIKtYlpsS	......IcslscKIDcIsp-IDuIptpos............VuucEVcDKlTGPlYDchTDus......sSIYssW....ssLE.-.E-ptL..tcLl.cELp-sRssLRoKlpEu...h.....hpscsphK.-sV...pVu-IKpDLEKLKStLEcVKcYLcspsNFE-IKthlps......	0	5	5	5
+6609	PF06781	UPF0233		Uncharacterised protein family (UPF0233)	Moxon SJ	anon	SWISS-PROT	Family	\N	22.10	22.10	22.20	23.40	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.39	0.72	-4.36	23	435	2009-01-15 18:05:59	2003-08-05 10:43:42	7	2	428	0	115	274	249	89.00	38	89.48	CHANGED	MP+SKsR.p+ssp....sspssscsssphp..tssPsWasslMhuLMllGLlWllVaYlossp........hslssLG..sWNlslGFGlhllGhLMThRWR	.................................................................................MPcSKlR+pssh........psss...s..pR.ss.+.hps...sssssWasslhluLhLlGLlWLlVaYluusp............l..hhssLG...sW.NhsIGFulhhsGhlhohtW+......	0	36	85	106
+6610	PF06782	UPF0236		Uncharacterised protein family (UPF0236)	Moxon SJ	anon	SWISS-PROT	Family	\N	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	470	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.49	0.70	-6.07	4	519	2012-10-03 01:22:09	2003-08-05 10:45:30	6	3	191	0	142	510	9	310.10	18	93.00	CHANGED	MK.....pll...s.s.htp.h.h.EpLhcsshphpEL.pplhcplsKlhtElltthLEElDphltEs.RcKp+ahlccKc.p+sLhThhGsloFcRsYYhs+...E-G+a..saLLDcsLthscppRlocslchcsVEtAVp.sSYR+uucpltp.ss..hlS+pAl+phlhEss........ph..p.spp++VRhLYIEADt.ahuhQ...............ctputps+LlhIHEG...cp.susc.cLlNp+aahs...EuscDhWtclpcal.ppYch-shcc.lhINGDuAsWI+EGhp.ahs+upa.LDRFHLs+.lh+shS+pP+h+Ecsp....+tlpcsDccGlhtllpchhsstc-EpccccIpchh+hIcs..puI..R.YRc.........pGlpuhuAttplschaSuRlpphshuWScpGL+tMh+lhshphsGsshtclchsc+p....s.hthspcpItpApc+lppphs-plppth.slppG+hs.Iapsh.uL+.uthl	.........................................................................................................................................................................................................................h............................................................hh..hlpth...Dt..l.h........pp.............c...t...tt.aph......ppp...........+sl...hhhG.plpap.R..p..h.a..hpt.....ptt..p..........a..lDp.hth.t.h.tphs...h....hhp..u......sac.pss...h.............lot.tlhphl..ht.......................................t..h...........l...hlE...sDt.hl.........................t....t....t..................t...h......hh..p................................t..h.t............h................t............th......th.t.hh..pta.t.....t......lhh.uDuu..........h.....h.p.....t.h.....h.t...........h..........pt........a.....h.D.aHh.p.l........phh..t.................t....h.....t.hh......phl........p.....t.h...h.p.p....h...t................t...........t.....t.........p.h..t.hhphl.p..........h..................................h...hu.....t.....p...p..h.h..s...Rhptt.h.Wp.tGhp.h.thh...h....p..t................................................................................................hh..............................................................	0	43	92	104
+6611	PF06783	UPF0239		Uncharacterised protein family (UPF0239)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	47.30	46.50	24.60	24.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.76	0.72	-4.06	2	75	2009-09-10 19:00:48	2003-08-05 10:46:39	6	1	65	0	48	74	0	82.80	48	94.00	CHANGED	.u.shshS.schs-.shhp.LlRYGLalGAlFQhlCl.Ahll......ps.s.sSpPcouEVTc+.ttsV.oh.++.+K.pKKKR.	..........MuuplshSPPElPEPTahEsLLRYGLFlGAIFQLlClLAIIl..P........h.sK.Sc...c.s...-...s.....p.sS...-s...+...ou.Ess+.K...sK...s...s.ssphp.++sKKEsKKKR.............	0	7	11	30
+6612	PF06784	UPF0240		Uncharacterised protein family (UPF0240)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	25.70	25.30	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.07	0.71	-4.59	8	106	2009-01-15 18:05:59	2003-08-05 10:47:43	6	1	87	0	68	102	0	162.80	34	90.81	CHANGED	MG...uhluRtlRpFNlENRAc+hIS+pKPsPAPKHPSTpcsLccplopaP-lhcEls+KDspLLopLK-VYVsSpDshs.......pscuspspspsK.h+Ls+....-apashh-scslPKGKlolhEALpLlNNH+hpP-pWTAcKIApEY+LcppsVssLL+YFhTFEV+I.Pscs..K+slpo+	.........................................................MG...uhlsRhh+sFNlE...sRAcR.I.u+.K.....P..psAP+asos..p.h....pcp.hp.pPchtccls.pKDs.pL.hsh...LKcV.YVsSpDPss...........t.t..s.css.t..sp..p.p..+.hpl.s+................shpashh..p...pplP+...G+lolhpALp.......lLs..sHp......hpPppWT..A-KIApEY....pLc.....ccVpslLcYF.hsFpVhl...Pspp...pp................................	0	20	25	45
+6613	PF06785	UPF0242		Uncharacterised protein family (UPF0242)	Moxon SJ	anon	SWISS-PROT	Family	\N	24.30	24.30	24.60	25.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.34	0.70	-5.79	3	41	2009-01-15 18:05:59	2003-08-05 10:49:24	6	1	40	0	7	21	0	372.60	60	90.66	CHANGED	MLhVKKhlHsC.uRYapYLhPVVAlLLPLVCaPFLSpSQKhYGYFVFolISSLGWFFAIGRRE+QLKTAAGQLLQTKIRKLTEpDEGLRpIRESlEERQpESsQL+lQNQKLlNQLhHlRGVFlKTKG-hQKLEsLltHL+EENQCLQlQLDALlQECsEKpEEsQELNRELAETLAYQQsLNDEYQATFoEQHNMLDKRQlYIGKLEuKVQDLMCEIRNLLQLESsIsENLPu+sl.AsSp-lstQLlSELKKIAFKsENIEAASSLTASRYlRTDoSVHNYSLECRQLFDuLREENLGMLFVYAPQSQRAVFANALFKTWTGYGlEDFLKh-SDVVISGhsQWccDL+o.SRpERSGKIVIKTKu+GplPFYYCLssLNKGPLspHVLGVLYPl+t-sLpu	..........................hhhsKphhH.h.uRYapYL.PllAlLLPlssaPFLS-pQhhYu.FlFsllSSLGWhFAIGhRE+QL+sAAGQLLpsKIRKlTEpDEGL+pIREolEcRQpEoppL+lpNpKLlpQLhpsRp.VFhpsKG+hp+hEpLs++L+EENQpLQlQL-Ahs+EpsEK..EsQEL.pELpEsLAYQQpLpDEYQATFsEQHsMLDKRQsYIGpLEuKVQDLMCElRNLLQLE....utpp.NLPucss.....uSp-Vs.uQLl..Eh+KIVF+VEshEAAsSLTA.RYhRoDs......SsHNY.....SLsCRQLFDuLREENLGMLFlYAPhuQRlLFANuLFpsWTGYGlEDFLpc-SDVVlEGhuQWEcDLh.op.S.RsERSGKIVIKTKsaGshPFYYClssLsKGPFspHlLGVLYPA+hshhp............................	0	3	4	6
+6614	PF06786	UPF0253		Uncharacterised protein family (UPF0253)	Moxon SJ	anon	SWISS-PROT	Family	\N	21.60	21.60	21.70	46.10	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.12	0.72	-3.86	8	619	2009-01-15 18:05:59	2003-08-05 10:50:18	7	1	618	0	44	123	2	66.00	80	98.68	CHANGED	MphY..CEhlRchYupIGSGDtGYlPcAIsCAlKsLN-IAuD-uLPpcVREcAAaAAANLLlSDacDc	....MEKY..C.ELlRKRYAEIASGDLGYVPDALGCVLKVLNEhAAD-ALSEuVREKAAYAAANLLVSDYVNE..	1	3	11	26
+6615	PF06787	UPF0254		Uncharacterised protein family (UPF0254)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	109.70	109.30	22.50	20.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.92	0.71	-4.71	11	29	2009-01-15 18:05:59	2003-08-05 10:51:15	6	1	29	0	20	29	1	161.60	46	94.29	CHANGED	MIpVATAECFTHGKIGpcIHthApGY............chh.cashsh.p....hsVhVlAuhFIPolpGlcoLLshc.sPcP..chshc.hsKsYsEEpDhcVAphMAcAlKchhssDIuIGTTAGIG+GuIsIlo-cpphlhoSDlauDLhps..EpIhpRQcsGIp+ulchFhplLp	.MIoVATAECFTHG+IGhcIHthAsGY.....................ch...ch.hs..t.........tslpVluuhFIPolpulcolLslc..PEP..Dhshc.hsKsYsE-pDhcVAhlMAculKchhssDIuIGTTAGlGRGuIsIlT-csphlhTSDVau.DLlps..-sIhcRQcsGIcKulchhlclLp.	1	5	10	16
+6616	PF06788	UPF0257		Uncharacterised protein family (UPF0257)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	26.00	25.10	24.50	22.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.59	0.70	-5.13	5	467	2009-01-15 18:05:59	2003-08-05 10:53:10	8	1	451	0	19	170	1	225.00	80	98.48	CHANGED	VKKhlLlshLsllLsGCDNscuLlSFTPEMASFSNEFDFDPLRGPVKDFTQTLMNEpGEVoKRVoGTLSQEGCFDTLELHDLENNTtLALVLDANYYRDAEThEKRVRLQGKCQLAELPSAGVoWETDDNGFVVSAoGKEMcVpYRYDuEGYPLGKTTKosDpTLSVsATPSsDPRKKLDYTAVSLLN-+plGNVKQSCEYDsYANPVsCpLlIVDESVKPAVpR+YTIKNoIDYY	..........................hKh.LL.sLLshhLsGCDpscsh.SFTPEMASFSNEFDFDPLRGPVKDFTQTLMDEQGEVTKRVSGTLSEEGCFDSLELLDLEN...NT...l....VA.....LVL.DAN..YY..RDAETL.EKRVRL..QGKCQ.L.A.E.LPS.AG....V.S.W.ETDD.NGFV...IK...A..SSKQ...MQ.M...E...YRYDD.QGYPLGKT..TKSND..K..T.L..S.V.S.A..TP.STDPI.KKLDYTAVTLLNNQRVGN....VKQSC.EYDuHANPVDCQLIIV.D.EGVKPAVERVYTIKNTIDYY.................	0	1	2	10
+6617	PF06789	UPF0258		Uncharacterised protein family (UPF0258)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	65.00	64.80	21.00	18.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.92	0.71	-4.18	3	82	2009-01-15 18:05:59	2003-08-05 10:54:07	7	1	37	0	53	66	0	142.50	52	26.69	CHANGED	KDW......p+ccKcupsQtDpPGosusshpsKuusLVEQVFssHlaPQ.......uLoS+hKlNPLass.RhsEht-sGRGRPSWTl-DY...........A+spGccuRlTPL.DLQTQESL.......NPNNLEYWMEDIYTPGYDALLRRKEApLRRs+VCKlhALIsAAVsTlILVlVIPICTl+S	..........................................................Qh-....tt..hp......pps..h.l-pshssc.hPs.........SLpotMKsNPLYsDhRLsEhhE.++spPSWTIEEY.....................s+pu.pps+.sth.sLpsp.p........NPNsLcaWh-DlYTPGYDoLLK+KEsch+RuKlC+lhuLIhhussslILVllVsIsTh........	0	2	6	19
+6618	PF06790	UPF0259		Uncharacterised protein family (UPF0259)	Moxon SJ	anon	SWISS-PROT	Family	\N	27.90	27.90	27.90	28.20	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.69	0.70	-4.93	6	639	2009-09-11 20:38:19	2003-08-05 10:55:36	6	2	623	0	78	301	78	229.20	59	95.61	CHANGED	MsITspsLh+DTapFhpspIhsIlhlSlLuAFIollIshlhpPsstpLhslhp...shchpuopS.lh-llpsMol-QpplLL+hSlsppFSuLIGsshLlGulITlIshlSptK+h.SlhpuIshsh.hlP+LhlLhFlTThllQlGhhLhllPGIhluIlLSLSPIILshc+hslhsSI+hShpIoapNl+lluPullhWlssKhlLlhlhSpFslls.pluhlIhNhhhN.llouILIIYLFRhYML....LRs	.....................................................MSITApSVYRDoGNFFRNQFh....TIL..LlSLLCAFIT..VVLGH.s.FSPS..DAQlAQLs-....G.sl..u..GS..uG....LF-.L....VQNMoPEQQQILLpASAAS....TFSGLIG...NAILAGGlILl..IQLVSAG....pRV..SALRAIGA.SAP..l.LPKLFILIFLTTLLVQIGIMLlVVPGIIMAIlLALAPV.MLVp-.KM.Gl.FAuMRSSMRLs....W.A.N.MR.L.V.A.....PAV..l.....u.WLLAKTLL.L.LFA.o..S.FA.s...L..T..Pp...l.G..A.V.LANTLSN.LISAlLL.IYLFRLYML..IR.Q..........................................................	0	10	28	53
+6619	PF06791	TMP_2		Prophage tail length tape measure protein	Vella Briffa B	anon	Pfam-B_3868 (release 10.0)	Family	This family represents a conserved region located towards the N-terminal end of prophage tail length tape measure protein (TMP). TMP is important for assembly of phage tails and involved in tail length determination. Mutated forms TMP cause tail fibres to be shortened [1].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.17	0.70	-4.71	30	1212	2009-01-15 18:05:59	2003-08-05 10:57:24	8	8	525	0	82	1164	33	176.50	41	24.61	CHANGED	pptttshp+uGhSscphstAhRtlPAQhTDIssuLuuGpsshhlhhQQGGQlKDhFGGhGsAh+ulsshlhullsPhsl...uAA........usuuLuhAaYpGupEscpascALllT......GstAGsTuupLt...........shAcplus.ssuThusAupsLspL.....suoGphsupphptlupAssphp.csTGpul--hlppFs+LucDPlcAshcLscphpFLTsupYpQIpu	..........................................................................................................s....hthppAGhSstphthshp.......h....lstQhsDlsspLAsGps.hhlhhQQGuQ.......lts..ua....G....G..........h.........h.....htsh......uGhl...sh....Ms....sh.s.......hss................................AsuuLu..h.A...a.Y.p.G.......p....pp....h....ptFN+sLhLo..............G.s.uGh....Tu.sphh......................................shucuhpu..sGhT......p.psutsL.....u..tl..................................VtuGsh.sut.pht..lspusspht..pusG...p.Vscs.hptFt+L.psDPssuhhuhspph+.lTApQlt.lt.p..............................................................................................................................	0	6	36	56
+6620	PF06792	UPF0261		Uncharacterised protein family (UPF0261)	Moxon SJ	anon	SWISS-PROT	Family	\N	18.70	18.70	19.10	19.10	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.16	0.70	-6.00	49	512	2009-09-11 06:27:46	2003-08-05 11:40:03	6	9	446	0	153	391	143	339.40	39	90.09	CHANGED	tpplhllGThDTKscELpalpshlcs..........tGhsslhlDlu..shsssshss.....-lotp-VApstssshpslhss...tD.RspAhpsMucuhsthltphhcptplsGllulGGosGTuLsssuM+.uLPlGlPKlhVSTlA.SG..slssYlGssDIsMhhSVsD.luGLNpIo+plLuNAAsAlsGMs.shptsp.........................spKPhlGlTMFGVTT.ssVstlpstL-sp...GaEslVFHATGsGG+AMEcLscpGhlsuVlDlTTTElsDhlhGG.lhsAGs-...RhsAAu+sGlP.VlSsGAlDMVN..FGuhcTlPc+aps.....RhhatHNsplTLhRTos-Estpluchlup+LNp...spGsVthllPhtGlSslDt.GtsFaDs-ucsALhssLcpslps..shplhclstHINDstFAcssltthtchhs...p	.............................plhlhuThDTKspEhhaltph.ltt...........tGhpshhlDluhh.....t.......ts.........slstppVAtttst..sh...ttlhst........D.+spAhthMu.uhpthl.ph.p...........lsulluhGGosGTslhssshp..tLPlG.hPKlhVSThA..SG..ssssYl..GssDlsMhhSVsD.luG...LNplSRtVLuNAusAluGhst.t.h..p..pst...........................ppKP.hlGlTMFGlTT.PslpthpttLppp.....sY-slVFHATG.s.GG+uMEpLh.pp.thhsuVlD....hTToElsD.lhGG..Vhssssc...RhpshucstlP.lhusGAlDMVs..Fs.s.po...l.Ptpats...............R.hatHN..tlolhRoos-EstthuchlutKLst.........spu...lthhlP.tGhSthDt.Gtsaa-s....cA.tAhhp..tlctsl.t..........phplhchshpINcstFApthht.h.phh.p.........................	0	39	99	125
+6621	PF06793	UPF0262		Uncharacterised protein family (UPF0262)	Moxon SJ	anon	SWISS-PROT	Family	\N	25.00	25.00	26.20	26.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.84	0.71	-4.51	24	243	2009-01-15 18:05:59	2003-08-05 11:41:08	7	2	240	0	86	194	178	157.40	58	97.24	CHANGED	hspsp.tR....LhclcLDEtolupssPDlEHERsVAIaDLlE-NpFs.Ps...Gst....sGPYpL+Lult-sRLlF-IpsEsss.lhsalLSLsPFRRllKDYFhIC-SYYpAIRouoPspIEAIDMGRRGlHNEGSplLp-RLpGKl-lDaDTARRLFTLICsLHh+G	...........................................................................................s...psRLscVpL.DE.oIuRuoPDl.EHERuVAIFDLlEEN.sFp.PsGcpt.......sG...PY+L+LSlh-sRLlFsIpp...EsG....ssl.ssHlLSLoPFRRlV+DYFhICESYYpAIRoA.oPSpIEAIDMGRRGlHNEGSpsLp-RLcGKl-lDFDTARRLFTLlCVLHW+G...	0	25	55	66
+6622	PF06794	UPF0270		Uncharacterised protein family (UPF0270)	Moxon SJ	anon	SWISS-PROT	Family	\N	20.10	20.10	20.70	20.90	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.03	0.72	-4.22	53	891	2009-01-15 18:05:59	2003-08-05 11:42:09	7	2	881	1	129	338	38	69.50	64	94.00	CHANGED	MI.IPap...pLss-TLpNLIEcFl...LREGTDYG-pEhSLppKlpplpppLcpGcsVlVaSELcE.....olsIhsKpph	..........Ml.IPWQ....-LuPETL-NLIESFV...LREGTDYGE+.Eco...LEQKVA-V++QLpsGEAVLVWSELHE.....TVNIMP+spF.............	0	19	51	95
+6623	PF06795	Erythrovirus_X		Erythrovirus X protein	Moxon SJ	anon	Pfam-B_9167 (release 10.0)	Family	This family consists of several Erythrovirus X proteins which seem to be found exclusively in human parvovirus and human erythrovirus. The function of this family is unknown.	21.00	21.00	21.10	182.00	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.69	0.72	-3.96	8	19	2009-01-15 18:05:59	2003-08-05 12:00:56	6	1	4	0	0	16	0	80.90	95	98.78	CHANGED	MDSYLTTPMPYHPVAVhQNLEEKMQYYLVKTYTSLGKLAYNYPVLTMLGLAMSYKLGPRKVLhTVLQGFMTLGIANWLSWE	MDSYLTTPMPYHPVAVhQNLEEKMQYYLVKTYTSLGKLAYNYPVLTMLGLAMSYKLGPRKVLhTVLQGFMTLGIANWLSWE	0	0	0	0
+6624	PF06796	NapE		Periplasmic nitrate reductase protein NapE	Moxon SJ	anon	Pfam-B_9066 (release 10.0)	Family	This family consists of several bacterial periplasmic nitrate reductase NapE proteins. Seven genes, napKEFDABC, encoding the periplasmic nitrate reductase system were cloned from the denitrifying phototrophic bacterium Rhodobacter sphaeroides f. sp. denitrificans IL106. NapE is thought to be a transmembrane protein [1].	25.00	25.00	30.30	29.70	20.70	18.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.69	0.72	-4.66	42	268	2009-01-15 18:05:59	2003-08-05 12:06:26	6	1	240	0	73	165	7	54.70	49	93.40	CHANGED	Mupssts......tpp+ppEl+sFlFLsshLaPlLoVshVuuYGFhlWhhQl.lhGP.PGt	..............Msp.s..ps....spc+uhEh+uFLFlsVlLFPlLSVuhVGGYGFlVWhhQh.lhGPPG.......	0	13	25	52
+6625	PF06797	DUF1229		Protein of unknown function (DUF1229)	Moxon SJ	anon	Pfam-B_9402 (release 10.0)	Family	This family consists of several hypothetical proteins of around 415 residues in length which seem to be specific to the bacterium Leptospira interrogans.	25.00	25.00	400.70	400.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.67	0.70	-5.63	2	57	2009-01-15 18:05:59	2003-08-05 12:32:44	6	1	38	0	1	51	0	393.60	94	99.59	CHANGED	MSTHFSLKSASVITDYLFKFRIFSLPAICWICSTLIGFGTVNGRLSLFVIGLSFIISIFLLKNIKWNISSTFSFLLVISFLLAYFFFYKTPNMPQHLDGKLNPILYVFKAFPTLFSFFIIhALPSLKQKKLFFIGIALGMFVFAIINSIATLVYLEPPYYGKAYHFFYKMEYNSPGITILASMLPIVLFCFNGYLLKIDKKLKWQNlFFIFVFLISLFISFLFSARTLFFLIIANIIILVLIRLWKIYSIPNKGIYYKFIIGFLILFVSCSSIYFFLKETYIGQRIMNGIYSEKLNHHVDYWNTlKKDFFIYPKITIGSEYTFWYHNIFFDSHKTSGPITALILYIYSVFhFLIuLKKSLKRDYRSFRYFHFYICFIPYLMTTIPWESSESQMVALFAGLGALITTVDDQTPEM	....MSTHFSLKSA.SVITDYLFKFRIFSLPAICWICSTLIGFGTVNGRLSLFVIGLSFIISIFLLKNIKWNISSTFSFLLVISFLLAYFFFYKTPNMPQHLDGKLNPILYVFKAFPTLFSFFIIFALPSLKQKKLFFIGIALGMFVFAIINSIATLVYLEPPYYGKAYHFFYKMEYNSPGITILASMLPIVLFCFNGYLLKIDKKLpWQNVFFIFVFLISLFISFLFSARTFFFLIIANIIILVLIRLWKIYSIPNKGIYYKFIIGFLILFVSCSSIYFFLKETYIGQRIMNGIYSEKLNHHVDYWNTIKKDFFIYPKITIGSEYTFWYHNIFFDSHKTSGPITALILYIYSVFIFLIALKKSLKRDYRSFRYFHFYICFIPYLMTTIPWESSESQMVALFAGLGALITTVDDQTPEM...............	0	1	1	1
+6626	PF06798	PrkA		PrkA serine protein kinase C-terminal domain	Vella Briffa B, Bateman A	anon	Pfam-B_3917 (release 10.0)	Family	This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This family corresponds to the C-terminal domain [1].	25.00	25.00	25.50	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.61	0.70	-5.09	43	1353	2009-01-15 18:05:59	2003-08-05 12:42:19	7	5	1291	0	335	779	130	252.60	58	39.39	CHANGED	lpKh+lYsGEsl..hs.psc.slpEl+cpusp...........EGMsGlSsRalhctlupslsp...psppsslNPlplhppLEpslcp....tplspEs.cc+Ylc...hlc.hl+pEYpEhltcElp+Aah..uhcEthppLhspYl-plcAalpcp.......+l+Ds.TGc.h-PD..Echh+uIEEplGI.spptpcsFRpElhsal..uphsppG.cphsa.....ssaE+L+....cslE+KLaushc-hlplhohsup..hsDcEppc+hcphlpRh.pchGYs-psApcllca	................................................................hSKMRVYDGEoLK..DTDPKAK..ShQEYRDhAGV.......D...............EGMsGLS...TRFAFKILS+VFNF........D+s....EVAANPVHLhYVLEQQIER....EQFPpEp.tERYL-.....FlKsaLhP+YsEFIGKEIQTAYL.ESYSEYGQNIFDRYVsYADF.WIQDQ.......EYRDP.-TGplhDR-u...........LNsEL.EKIE..K.........P.......A.........G.........I...SN...........P....K.........DFRNE.IVNFVL.........RARAsNsG...+NPsW.......TSYEKLR...........sVIEKKM...F.S.N.T.E-.LLP.VI....S....FNAK...........sS....s--QKKH-DFVsRM..hE+GYTcKQVRLLsEW......................................................................................................................	0	95	195	270
+6627	PF06799	DUF1230		Protein of unknown function (DUF1230)	Moxon SJ	anon	Pfam-B_9232 (release 10.0)	Family	This family consists of several hypothetical plant and photosynthetic bacterial proteins of around 160 residues in length. The function of this family is unknown although looking at the species distribution the protein may play a part in photosynthesis.	25.00	25.00	28.90	53.10	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.92	0.71	-4.33	30	130	2009-01-15 18:05:59	2003-08-05 12:58:07	6	1	106	0	65	129	126	141.00	42	70.98	CHANGED	CPVP.-QpPlNEYppLpsSWhFoWsshsttsah+pLhhhWllshhlss.slAuuSashpcsshchllsusluuhllshLlllRlYLGWsYVtcRLhSpsVpYEESGWYDGQhW.KP.-hlt+D+LlupYpV+PlLsRLpp...ohshhs	.....CPVPhEQpPlNEYppLppShhFuWsshs..hhsa..ht+L...........shl.W.h.hs.hhlsu....Pl.Au.uSas..spppsl+hlLuussuuhhllsLlllRlYLGWsYVtcRLhStsV.YEESGWYDGQhWhKPsElLsRDRLluoYpV+PlLpRLppThsh.s........	0	17	44	58
+6628	PF06800	Sugar_transport		Sugar transport protein	Vella Briffa B	anon	Pfam-B_4126 (release 10.0)	Family	This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins [1], ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.90	0.70	-5.31	17	1288	2012-10-02 19:55:49	2003-08-05 13:02:27	7	5	732	0	128	848	304	260.80	40	91.36	CHANGED	hsllssKl.GGpPhpQhhGhTlGALlFulllhlhppsshs...phhlhullSGhhWulGQhhQF+uhchlGVS+sMPISTGhQLVGsoLhGVlsFtEWssshphllGhlAlllIllGhhLTuhpccpct..pp..pshp+ulhhLllSolGYhhYsll.sph......hslsGhsslLPQAIGMlluullhsh........chhhpKhohhNllsGlhWuhGNlhhlhSst..hsGlATuFSlSQhuVllSTlGGIhhLsEKKT++EhlhlhhGllLllluulhh	.............................................................................sllssKh.GGpPhpQhlGsTlGA.L.lFu...l...l...l.h..l...h.....s..p.....s..s.....h...s...........sslllu....llS.Gh.h.Wu.hGQhtQh.+uh.......p...hlGV..SpsMPl.ST.G..hQL...Vu..soLaGVlhh...t..E...Ws..s.h.......t.....p....h....l.l.Ghl.A.l.l.l..l.l.l.Gs.h.h.T.u.hp-cppt...........ts.......stsh.++u.l.h....h.L....l.l.S....ol.....GY..h...s.Ysll.sph..................hs...l.....s..........G........h.s.A.lL.P...Q..u.l..G.........M..l...l.u.......u...llhsh.................pch..h.h...p....K...h...o...h.h...N...ll...s.Glh.Wu...h.GN....L.h....h.llStt...tsGl..A.Tu..F.sLSQh.u.Vl.lSTLGGIhhLsE.....+..K.....T.....+...+...p...h....h...h...l....l...l...Gl..l..LIll.uull.h........................................................................	1	41	76	103
+6630	PF06802	DUF1231		Protein of unknown function (DUF1231)	Moxon SJ	anon	Pfam-B_9856 (release 10.0)	Family	This family consists of several Orthopoxvirus specific proteins predominantly of around 340 residues in length. This family contains both B17 and B15 proteins, the function of which are unknown.	25.00	25.00	105.70	105.60	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.28	0.70	-5.56	3	51	2009-01-15 18:05:59	2003-08-05 13:11:15	6	1	18	0	0	39	0	300.00	94	99.99	CHANGED	MSRKFMQVYEYDREQYLDEFIEDRYNDSFITSPEYYSAEKYMCRYTTLNHNCVNVRRCALDSKLLHDIITNCKIYNNIELVRATKFVYYLDLIKCNWVSKVGDSVLYPVIFITHTSTRNLDKVSVKTYKGVKVKKLNRCADHAIVINPFVKFKLTLPNKTSHAKVLVTFCKLKTDITPVEAPLPGNVLVYTFPDINKRIPGYIHVNIEGCIDGMIYINSSKFuCVLKLHRSMYRIPPFPIDICSCCSQYTNDDIEIPIHDLIKDVsIFKNKETVYYLKLNNKTIARFTYFNNIDTAITQEH-YVKIALGIVCKLMINNMHSIVGVNHSNTFVNCLLEDNV	..MSRKFMQVYEYDREQYLDEFIEDRYNDSFITSPEYYSAEKYMCRYTTLNHNCVNVRRCALDSKLLHDIITNCKIYNNIELVRATKFVYYLDLIKCNWVSKVGDSVLYPVIFITHTSTRNLDKVSVKTYKGVKVKKLNRCADHAIVINPFVKFKLTLPNKTSHAKVLVTFCKLRTDIT.IEAPLPGNVLVYTFPDINKRIPGYIHlNIEGCIDGMIYINSSKFACVLKLHRSMYRIPPFPIDICSCCSQYTNDDIEIPIHDLIKDVsIFKNKEhVYYLKLNNKTIARFTYFNNIDTAITQEHEYVKIA.LGIVCKLMINNMHSIVGVNHSNTFVNCLLEDNV.	0	0	0	0
+6631	PF06803	DUF1232		Protein of unknown function (DUF1232)	Vella Briffa B	anon	Pfam-B_4265 (release 10.0)	Family	This family represents a conserved region of approximately 60 residues within a number of hypothetical bacterial and archaeal proteins of unknown function.	20.80	20.80	20.80	20.80	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.68	0.72	-4.51	172	1698	2009-01-15 18:05:59	2003-08-05 13:26:27	7	20	1207	0	565	1384	202	40.10	37	27.25	CHANGED	htst.hh.lhuuLhYhlsPlDlIPD..hlsslGhlDDhsllshs	.............h.hs+hh.lhuuLsYhl.P....lDlIPD..hlsslGalDDlsllsh........	0	189	354	460
+6632	PF06804	Lipoprotein_18		NlpB/DapX lipoprotein	Moxon SJ	anon	Pfam-B_10405 (release 10.0)	Family	This family consists of a number of bacterial lipoproteins often known as NlpB or DapX. This lipoprotein is detected in outer membrane vesicles in Escherichia coli and appears to be nonessential [1].	20.00	20.00	20.20	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.65	0.70	-5.67	6	1056	2009-01-15 18:05:59	2003-08-05 14:05:53	6	3	1001	10	191	616	78	267.20	36	77.58	CHANGED	sYLcossLcshpsP....tsuhPph.ssYsIPQsshpGulGKpVDIRPPpQsLpLIsGARs-p..sGEsoLhLlcp-cts.clWppVtchLp-+pIPlpppsDut..lpTDWVsWsptDE-hphtuRYpIShhEsssppuhpVsLlsh+csstlpssshos+pRYNshMhNllouphDpshR-pApcpApchVppIslshGoDcoGhPllIsRuPYNVlWQRLPslLPKhGFsIc-RspSQGTlpsKYtussDc.WpplGsKs....-LKoGsYph.lGDLGNRoSlshTDssG+slspu.hcuLVsVLpAlls	.....................................................................................................................................................sYLpu.ssht.lp.sP...sGhh.h.Ph.......tss.........sYsI..P...s...s...p..s...p...Gu...lG...c.sl..D..I...R...P.P.......t..Q......s..LsL..l...s...Gu...R.sph.....sG-..su...l...l....l..c.....s.....s.....p.....s..s.....plW....spVhph....l....pt....+..s.hsl..pp..cs.Dus.....lpT.............D.......W..............l...........p.........W.s..............c........h.........D.............E................D.................p.......h.............c.u..R..Y..p..I....o...ht......p..shp..t..ulp..V....pLl....s.hc....p.........u..t.t........s....s...s...ss.....s..h...QR.....Y..............s...s...t...MhN.h.lsst...LDpst...s.c..s..........s..............ss.....t.......t.....s....c.......t..s...............s..s.....h..........sl....p...........u....u..D...c.....o......G....h......P.h...Ll.lRuPFshlWpRLPsAL-+lG.hcVsDpsRSQGshtV....p..Y........ps....h........s.......-.......u.........t......W......p.c........L..G...u.pc................ss.L..s..u.G..c........Y+l.pV..G...D...L....s..N..R..o.S.l.ph.lDscG+sLopupscslVuVhpAsh............................................................................	0	31	84	141
+6633	PF06805	Lambda_tail_I		Bacteriophage lambda tail assembly protein I	Moxon SJ, Iyer LM, Burroughs AM, Aravind L	anon	Pfam-B_7725 (release 10.0)	Family	This family consists of tail assembly proteins from lambdoid and T1 phages and related prophages, e.g. the tail assembly protein I  (TAPI). Members of this family contain a core ubiquitin fold domain  [1]. The exact function of TAPI is not clear but  it is not incorporated into the mature tail. Gene neighborhoods  reveal that TAPI co-occurs with genes encoding the host-specificity  protein TapJ, and TapK, which contains a JAB metallopeptidase fused  to an NlpC/P60  peptidase. It is proposed that the TAPI protein is  processed by the  peptidase domains of TapK [1].	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.60	0.72	-4.16	15	1136	2012-10-03 10:59:06	2003-08-05 14:19:07	7	4	504	0	59	868	33	71.30	56	35.56	CHANGED	shsplpLtGslt......p+aG+htthsVpThuEulpALusplsuacphh.pth.....atlhhst+N.uccsl.t....ttshsGssI+IlPhstGu	...............................h.................................p..T..u..A..EAIRALu.hQl.PuFRppls..............................-GWYQVRIuG....cDsutstL.ApLp..Es..LssGuVIHIVPRlAGA..................................	0	6	22	42
+6634	PF06806	DUF1233		Putative excisionase (DUF1233)	Moxon SJ	anon	Pfam-B_9240 (release 10.0)	Family	This family consists of several putative phage excisionase proteins of around 80 residues in length.	21.30	21.30	21.40	21.60	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.33	0.72	-4.43	13	472	2009-01-15 18:05:59	2003-08-05 14:24:08	7	1	322	1	19	108	0	65.40	48	88.75	CHANGED	VI.....ls.PscWVsEclLhAlTGLptusIp+ARcpuWhpG+EY++VuPDGpPcss.upshYNhtpIspWIcp....pP	.........l..sscWlsEp.LhshpGl..pttsl.p.+h.Rcp.saMpG+EYKHlu.s-GpPtcp..S.ChYNhccIspWIEpQt..su...............	0	1	5	12
+6635	PF06807	Clp1		Pre-mRNA cleavage complex II protein Clp1	Moxon SJ	anon	Pfam-B_9787 (release 10.0)	Family	This family consists of several pre-mRNA cleavage complex II Clp1 (or HeaB) proteins. Six different protein factors are required in vitro for 3' end formation of mammalian pre-mRNAs by endonucleolytic cleavage and polyadenylation. Clp1 is a subunit of cleavage complex IIA, which is required for cleavage, but not for polyadenylation of pre-mRNA [1].	28.90	28.90	28.90	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.34	0.71	-4.54	16	510	2009-09-11 15:53:51	2003-08-05 14:32:10	9	17	273	2	375	523	8	194.00	21	39.16	CHANGED	GWVpGhGhclLlchlcsasss....hVlVl..sp.E+LhscLppthhsp......................lpllclsKutGVs...........................pRspchR+phR-ppIhpYFh.G.hpssh...hPashsspFsDl................pha+l.....hssssL.lshpspsssh+l......thslhppllAlSh............tpts-sll.......ssslsGFhhlptVDlp+chhslLoPsstp.L.PsshLlhus.lpa.cs	................................................................................................................................GWhps.GhphLhchlpthpss....hllhl.....s....p....c+..hh.s.pLp..p.ph..spp..............................................lp.llt..l.scs..sus.s......................................................................pp.s..pp..h.t...pp.hRc.plp..pYFa....u.........h...p...ts..h....................Phs...ts.s..h..ssl..................................................................p.acl........shssss.....l.....h.....h.p.t....p....s...s..tcl...............................sl.t.p.llulsh................................................................st..t.t.p..s..hh......................p.ssshGashlpsl...............D......h..p..+p...hhpl.LsPh..sh.....L.....s.p...hLl.hst.h......................................................................................	0	144	216	312
+6636	PF06808	DctM		DctM-like transporters	Vella Briffa B, Bateman A	anon	Pfam-B_4075 (release 10.0)	Family	This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers [1]. Note that many family members are hypothetical proteins.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.27	0.70	-5.92	18	7152	2012-10-02 15:12:49	2003-08-05 14:32:48	7	20	1871	0	2023	7864	11933	404.70	26	85.53	CHANGED	lshhhlLhhhuhPluhulhlsul..hhhhhhsss...........sh..lhspphhs.......u....lsshsLhAlPhFlLhGslhppsGhuccllchssullG+h+GGhuhsslhuuslhuulSGSulAsssslGuhhlPhM++pGYssshAuAlhAuuushu.llPPshshllauh..............hsslSluslFhAGllPGll....................................hhlslhhsshhhAp.+psh.s............................tscsphtphhpuhhpuh...........................................uLhlsllllhulhhGh.....aTsTEAuuhulshu..Lhlullh..........h+chshcclhcs........Lhpsucss....usVhhllAuuulhuahlohsslshtlushlhulss..................st..hhhLllsslhhl..llGhhl-ssAsllIlsPlhhPlhtphGlDP................lahGlhllhshslGhhoPPVGhslaluuuIu..............p.sshhpsh+tllPalhshhssLlLlshlPtl	..................................................................................................................................................................hhhlhh.h..h....hu.h..P.l.u.h...u.l.shsuh.......hh..hh..h..h..ssh..............................................................sh...h.h..spp.h.hs.............................s....h.s.s.h.s...L.h.A....lP..hF...l...L...h.....G.....tl...hppuGlucclls.hs.tt.h.........hG..+....h.......G....G..Lu.....hs....s..l.l...u...shlh...uu.l.S...G....SusAsssuhG....sl....hlP....hM........h.+.t...G.Ystp.h.u.sulh...suuu..sl.G.....l..IP.....PS.hs..h.ll.auh............................hss..hS....l......u......pL........F....h....A..G...l....l...P....G..l..l..................................................................................................................................................h...s..h...s...h...h....h....h....s...h....h....h.....up......+.t...s...h..s.s................................................................................................t....p..h....s....h.....t........p....h......h......p....s.....h...h....p....u....h............................................................................................................................................................................................................s.L...h..l....l....l..l...l..G....u..l....h.s....Gl..........................hT.P...T...E....A.....u....u........l....u......s...h.hu........l.h..l.uh.h................................................................h+p.h..s...h....p..p...l..h.ps.................................................................lhp.s....s.pso........uh.l.....hhl..lus.............us....h.h.u.h....h.h..s..h.t.t.l..s.t.h.l...s....p.h.l.h....s.l.s..s.............................................s.........hh.h.L..l..l..l....l..h....h.l....llG.h..hh.....-h...s....s.....h..hl.l..h.s....P..lh.hP.l.h.....h....p....h......G.......l.D.s........................................................................................la.F..Glhhhh.s....ht.lu.h....l....TP...PlG.hs.l.F.s.s.s.u..lu.....................................p..hpht.p.lh.+.s....l.l.....P..a...h.h...s...h.h.h..s.Lhl.ls.hhPt.....................................................................................................................................................	0	616	1374	1743
+6637	PF06809	NPDC1		Neural proliferation differentiation control-1 protein (NPDC1)	Moxon SJ	anon	Pfam-B_10407 (release 10.0)	Family	This family consists of several neural proliferation differentiation control-1 (NPDC1) proteins. NPDC1 plays a role in the control of neural cell proliferation and differentiation. It has been suggested that NPDC1 may be involved in the development of several secretion glands. This family also contains the C-terminal region of the C. elegans protein CAB-1 (Swiss:Q93249) which is known to interact with AEX-3 [2].	19.20	19.20	19.30	27.80	18.70	19.10	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.26	0.70	-5.65	2	114	2009-01-15 18:05:59	2003-08-05 15:07:05	6	6	79	0	62	116	0	192.70	37	65.07	CHANGED	MATPlPPPSPRHLRLLRLLLSGLlLGAALpGAsAt+PDsssCPGSLDCALKRRA+CPPGAHACGPCLQsFQEDQpGhCVPR..hppsPu.....sphEscI...........shLhQELA..cKEuGHS...s.PL.cstQ+L.EP.ATLGFSthGQtLE.GLPST.GTsoPhPHTSLuS.sSSsPVpMSPLEPpGtpGsGLsLVLILAFClAuuAALuVAuLCWCRLQREIRLTQKADY.ATAKuPsSPusPRISPGDQRLApSAEMYHYQHQRQQMLCLERHKEPPKEL-oASSDEENEDGDFTVYECPGLAPTGEMEVRNPLFDHusLSAPlPuPpS.PsL.	...................................................................................................................................................................................................................................................................................................................................................................................................................................h....hlhshhh.s.ss..h.Al.h....s.lshh....p.h..ppp.+.hstc.sDa...s.shus.s..uss.t.s.t......s.s.G.Dp+LApSApMYHYQHQ+QQhlshE.......ppp...p............sp..t..hp..s.s.pSD--NE-....GDaTVYECPGLAP....T..GEMEV+NPLF..cts........................................................	0	21	27	45
+6638	PF06810	Phage_GP20		Phage minor structural protein GP20	Moxon SJ	anon	Pfam-B_8431 (release 10.0)	Family	This family consists of several phage minor structural protein GP20 sequences of around 180 residues in length. The function of this family is unknown.	31.00	31.00	31.50	31.20	30.40	30.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.97	0.71	-4.78	21	296	2009-01-15 18:05:59	2003-08-05 17:04:18	6	1	261	0	41	246	4	154.40	25	79.64	CHANGED	pcplcplht.cupslt....Ks+hscs...pp....chcsl+pQlspRDpQlp-Lpc.pspDs--Lppcl-cLcppNc....-appclpphphssAlchALschsu+sscslhuhlspDplcLcc-s.lhGL--QIcsL+EScsYLFsppp....pPssuh.......sssssu	.........................................................................................p.hptl.......t.tspplp......K...s...chsph.......pp.......phcslcpp.......lppt-cplccL+c.....p.....stss--L....ppplccLppcs...cp....ttchppchpphph..ssAlchALps..h.....pA...p...s...s...cs.lh.uh...l.D..h-...plclsc-u..lpGL--tlcsLK..cSc..s..aLFtppp...t..pPt.t...........sss............................................	0	23	36	39
+6640	PF06812	ImpA-rel_N	ImpA-rel_N-term; 	ImpA-related N-terminal	Vella Briffa B	anon	Pfam-B_4308 (release 10.0)	Family	This family represents a conserved region located towards the N-terminal end of ImpA and related proteins. ImpA is an inner membrane protein, which has been suggested to be involved with proteins that are exported and associated with colony variations in Actinobacillus actinomycetemcomitans [1]. Note that many family members are hypothetical proteins.	20.60	20.60	21.00	20.60	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.68	0.72	-4.20	143	1962	2009-01-15 18:05:59	2003-08-05 17:19:59	7	7	932	0	298	1333	37	61.00	28	14.43	CHANGED	DWstlpchutpLLtpcoKDL+lssaLspAhh.ctpGhsGlspGlpLLssllppaW.-slaPths	..........sWstlpchuhpLLtspuKDl+lssahhhuht.+ptGhsGhspGlpLLsthlpp.aW.ss.haPp..h.................	0	43	112	200
+6641	PF06813	Nodulin-like		Nodulin-like	Vella Briffa B	anon	Pfam-B_4440 (release 10.0)	Family	This family represents a conserved region within plant nodulin-like proteins.	24.70	24.70	24.80	24.90	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.63	0.70	-5.12	15	586	2012-10-03 03:33:39	2003-08-05 17:21:06	8	13	122	0	360	786	6	218.90	26	41.90	CHANGED	+WhsllAulWlQusuGssasFu.sYSusLKSsLGhsQppLNhLuVApDLGcslGhlSGlssphhPsWsVLhlGAshshlGYGlhWLsVopplstLPhWhlhlhlsluuNSpsWhNTAsLVoCl+NFPtsRGlVlGlLKGYsGLSuAlaTplYpulhss....cssshLLllAllPslVsLsslahlRsp......spssppps-sthFhhhhhlulhlAsYLlshsllpphhshopuhhhshsulhl.lLLlsPLslPl	......................................................Wh.h.hhuuhhlt.hhsG.ss.YhFu........hYSstlK.s.t.h.s......h.sQppls..h.luh....hp.s.lG.t.s..h.G....h.h...u...Ghl......h.p......h......h.............s................s..hhllhlGu.h.hshh.G.Y...h...h...h..........a..L..s..........l...s......t......t...........h......s...................s........h.h.h........h.s...l.h.h.h...l.u..ss..u....t.s..ah...................s.Tu...sll.......osh....pNF..P..p..s..R..G.sslulh+uah.G.L....SuAlhop.lhp.s..hats...........s.s.ss...h...l.L...hlAhh....ss.h.....l....s.l..h.h.h.......h......h.l..+...h.............................ttt....tpt...hh....h......h........h.h...h...slh.hu..h.aLhhh..hht.t.........h.sp...h..h..hhh.h..hhlh.Phhls...................................................................................................	0	73	240	310
+6642	PF06814	Lung_7-TM_R		Lung seven transmembrane receptor	Vella Briffa B	anon	Pfam-B_4367 (release 10.0)	Family	This family represents a conserved region with eukaryotic lung seven transmembrane receptors and related proteins.	25.20	25.20	25.20	25.30	25.10	24.90	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.75	0.70	-5.46	15	836	2012-10-03 04:04:29	2003-08-05 17:23:36	8	8	290	0	523	853	12	251.00	26	55.43	CHANGED	lscoGhYslhhh.sp.p......t.psshshpsplsa+NspGYLsAp-hPLh.hYshMslsYslhullWhahhh+ah+DllplQhaIsullhluhsEhsFaah-YthhNspGhs...spshslas.lhuuhKtolstlLlLllShGYGlV+PpLGshhp+lhhlulhhhlhuslhhlhppsuths-tp....thlhhhlPl..uhl.hhhlhWIFpSLsc.ThcpL+h.+RshsKLplYR+Ftsslshullhohsahhhp.lhh...pthsshpptW+.tWlhs.saW.cllshslLllIshLWRPopNs.	......................................................s.Y.lh..h..h.................................s..h....p...h.ph.p.h....p.h...ps........s.....h..u......a.Lsus....phP.h.............hYhh..hslhYh...lh.u.h................hWhh.h.h........h..p...h..h..p.............s......l..h.plphh.h...su...l...lh...hthlphh...hh.hh.pa...p..hs..............p.pG............................sps....hhlhh.lhphh+tshhhhllllluhGauh.lK.s..h......L...u.......p........t.............p....+...l.hh.lsh....h.lhusl....h.........l..........l...........h..........................s......................s..s.t...................................h.lhhhlsl............shh...hh....hh.W..............h....p..p.............L...pp...oh.p...p.h....+..................h....tp...p............hs..KLp.....la...............R+.ah.h.ll.h.hlh.....h..ohh...hhhh..h......................h...pWp....W.h....shh.ph.hhhhh....hh.hhh......hha..RPstss.............................................................................................................................	0	155	276	408
+6643	PF06815	RVT_connect	rvt_connect;	Reverse transcriptase connection domain	Bateman A	anon	Bateman A	Domain	This domain is known as the connection domain. This domain lies between the thumb and palm domains [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.26	0.72	-4.14	47	20194	2009-01-15 18:05:59	2003-08-05 17:58:29	8	56	614	372	0	19630	0	90.20	85	13.88	CHANGED	sYYcPpKsLhAclpKhGpsQWsYplhQ..pp+..sLKsGKau+t+ssHsNshcpLApslpKIucEuIVIWG+lP.pFcLPlp+Es..WEpWW.s-YWQsoWIP-hEFlsT	..............................................................VYYDPSKDL.....IAEIQKQGQGQWTYQIYQ...EPFK...NLKT.GKYARhRuAHTNDVKQLTEAVQKIuTESIVIWGK.TP.KF+LPIQKET..WE.......................................	2	0	0	0
+6644	PF06816	NOD	NOD; NOD1; 	NOTCH protein	Guo J, Studholme DJ	anon	Guo J	Family	NOTCH  signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be  elucidated.	19.40	19.40	19.60	19.40	19.00	19.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.64	0.72	-4.88	26	289	2009-09-11 05:54:01	2003-08-06 11:46:38	8	241	92	8	132	222	0	56.10	43	2.77	CHANGED	PtpLApGsLlllVh.lsP-ph..ppsussFLRcLSplL+TsVph+pDspGpsMlaPahGp	....PtpLApGsLVlVVL.hsP-pL..hpsut.sFLRp.LSplL+Tslph+pDupGp.MlaPYaG......	0	23	35	81
+6645	PF06817	RVT_thumb	rvt_thumb;	Reverse transcriptase thumb domain	Bateman A	anon	Bateman A	Domain	This domain is known as the thumb domain. It is composed of a four helix bundle [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.30	0.72	-4.40	41	66982	2009-01-15 18:05:59	2003-08-06 12:13:26	9	77	671	372	39	66594	2	64.00	90	13.78	CHANGED	KWplQpIpLPcp-..phTVNDIQKLVGcLNWAu.Ql.YsG.I+sKpLCKLlRG.sKsLs-hVthTcEAchElpcN+	.......................KWTVQPIhLPEKD......SW.TVNDIQKLVGKLNWA......S.QI..YsG..IK..V+..QLCKLLRG.sK.ALTEVlP.LTcEAELELAEN.................	0	13	13	14
+6646	PF06818	Fez1		Fez1	Vella Briffa B	anon	Pfam-B_4593 (release 10.0)	Family	This family represents the eukaryotic Fez1 protein. Fez1 contains a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5 [1]. There is evidence that Fez1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth [2]. Note that some family members contain more than one copy of this region.	26.40	26.40	26.90	27.60	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.61	0.71	-4.30	8	300	2009-01-15 18:05:59	2003-08-06 14:17:55	10	3	66	0	170	232	1	152.80	38	31.58	CHANGED	TKWEVCQKSGEISLLKQQLKESQAELuQKuuEIluLRuQLREuRupLpspEtphpcLc-uh+T+sLELElCEsELQR++sEAELLREKss+l-tElscL+-Ahuup..........t..s..h...............................ESDE...AKupcts......................tsshpsLRppl-RLRAELptERp+tEcQusuFEcER+lWQEEKEKVIRYQKQLQpsYlpMYpRNppLE+cLpp	...............................................................................................................................opWEVC...QKuGE..ISLLKQQL+-uQsElspKhuElluL+s..p.L+..-sRuphptp-tph.tL....pt.uh..........ps.ct.phc..tptph..................................p.......................................................................................................................tpt...st..t............................................................................................h.th...p.tphppLpsEL....ERpttcp.t.sFptERhsWptEK-+VlpYQ+pL.Q.sYlpMYpRNptLEptlp.......................................................	0	17	33	82
+6647	PF06819	Arc_PepC		Archaeal Peptidase A24 C-terminal Domain	Yeats C	anon	Yeats C	Domain	This region is of unknown function but is found in some archaeal Pfam:PF01478. It is predicted to be of mixed alpha/beta secondary structure by JPred.	21.20	21.20	21.20	62.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.18	0.72	-4.14	10	35	2009-01-15 18:05:59	2003-08-06 14:21:48	6	2	35	0	27	37	0	111.70	35	30.52	CHANGED	Vh.phllhlhplpLIhtllpALTsttls.ccKpV-ELKEGDILt-hIhlpssG.Vhh-pushhcRhKphLcsEpscslp....ccllsssuEGLocEpIEcLKKLssEGKlpsEhpV	.hl..phhlhlhtlpLl.hllhuLpsttls.-c+pl-ELKEGDILt-hIhhcsst.Vhh-psshhcRlKphlpstphps......tchllhssuEGLocEsIEhLK+LhpEGKlpsch.V.....	0	4	7	18
+6648	PF06820	Phage_fiber_C	Tail_fib_C-term; 	Putative prophage tail fibre C-terminus	Vella Briffa B	anon	Pfam-B_5030 (release 10.0)	Family	This family represents the C-terminus of a prophage tail fibre protein found mostly in E. coli. All family members contain a conserved RLGP motif.	25.00	25.00	26.60	25.90	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.07	0.72	-3.84	2	1275	2009-01-15 18:05:59	2003-08-06 14:42:52	7	14	118	0	2	871	0	62.30	64	34.03	CHANGED	hphRLGPAsIlEosppGhhPtpD.tlITtlshL.stDppplQshhp.LQlhhuDG.WpsltGhc	.........hphRL.GPAsIlEospNGhhP-pD.tlITtlshL.stDtpQlQslhR.LQlhhuDGsWpsltGhc.................	0	0	0	2
+6649	PF06821	Ser_hydrolase	DUF1234;	Serine hydrolase	Vella Briffa B, Eberhardt R	anon	Pfam-B_4941 (release 10.0)	Domain	Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile [1].\	      This family has an alpha-beta hydrolase fold [2,3]. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family [3].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.11	0.71	-4.66	24	1243	2012-10-03 11:45:05	2003-08-06 14:56:12	8	3	948	5	341	1631	220	168.30	26	89.49	CHANGED	hLIVPGapsSus.sHWQoaWpcphssu.pRVcQt-W...ppPshs-WlstLppslsttsts.......sllVAHSLGClsss+hs.....hpttc..pVtGALLVAPsDs.............p...tstthtsFuslPpp.LsFPo.....llVAScNDPasshppApphApsWGuthlslGpuGHINs-SGaGsWPpGhhlLsp	......................................................................................................................................hlIl.G..h..p..u..s..ss...sH..W...sh.h....pc.p.l..st....t.......h........c...V.....p...........h.......sa...........pp.P...s....h....s....p........W.....h.........t..t....lp...p.......tl..s....t...t....p...p.s..........s.hlVuHSLGslssl+ah..............ttpp...pl.t.G.h.l..LVA.s.h.c..t............................................................t.....t..s.....h.h..p..s.h...s.....s....h..s...p...p..t..h..s.h.ss....................hl.....l..u.S.cNDsa.ss..h..p.p.u.p....pl..A.p.sh..s.....u.p..hhtl..spuG.Hhss.psGassastshth...p..........................................................................................................................................	2	59	167	254
+6650	PF06822	DUF1235		Protein of unknown function (DUF1235)	Vella Briffa B	anon	Pfam-B_4988 (release 10.0)	Family	This family contains a number of viral proteins of unknown function.	25.00	25.00	39.30	39.20	20.70	18.30	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.75	0.70	-5.42	11	73	2009-01-15 18:05:59	2003-08-06 15:05:26	7	1	38	0	0	65	0	226.30	54	91.54	CHANGED	hIPaFs.s+I......+splhcLss.s.......hhpYht..HsphIlpEIc+al...s-plhssshlslphacpppshp...pspspshS+lllClpuAp+GGslllpsphss.p+pllp.sssphllLSPLucYsVopVp+GshlllslclsIPSMc....lhhhstpsl+asNslplLhPhpts-lsFsl+plhDhpsscllCEQllINpcWYTlls..sssp+lhlPSh..ChGpoh..chsaspss.cc-hlpp..llshpsPF-.hlhPp+sIYsuh.lt...E+llYG+l	...............hhPhFshSKI......pshl...sNss.......pphYhcsEHp+IIocEIsRpM...DEsVLLTN.ILSVEVVNcNEMY....HLIPHRLSpIILCISSl..GGCVISIDNDlN.sKNILTFPIDHAVIISPLuchsV..VsKGsshllllcsDIPShR....llsoh.sssIhYsNsLsLls.lshS..VFlIRploDhh.s++lC-QIFhNs+WYolIs....hssKpasIPSs..ClGhos...spYlssoh-pDhlh+..lhNl-hPFD.hla.+hpsYsSlsl+...EpILYG+I.	0	0	0	0
+6651	PF06823	DUF1236		Protein of unknown function (DUF1236)	Vella Briffa B	anon	Pfam-B_5056 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function. Some family members contain more than one copy of the region represented by this family.	20.60	20.60	20.60	21.70	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.19	0.72	-4.25	57	317	2009-01-15 18:05:59	2003-08-06 15:12:02	7	9	104	0	164	322	7	64.40	33	37.89	CHANGED	YVppp.l.....tshsh..ptclsVGsslPcs..Vplpsl..Psp.....s...sYpYslVN-.chVlV-PpoRcIVpllc	..............................hlppp.s...shth...phclsVGsslPcs...Vp..lpsl...Psp......s......sYpYslVs-.chVlV-PpT+clVpVlp...	0	22	74	102
+6652	PF06824	DUF1237		Protein of unknown function (DUF1237)	Vella Briffa B	anon	Pfam-B_4981 (release 10.0)	Domain	This family contains a number of hypothetical proteins of about 450 residues in length. Their function is unknown, and most are bacterial. However, structurally this family is part of the 6 hairpin glycosidase superfamily, suggesting a glycosyl hydrolase function.	20.10	20.10	20.70	20.60	19.30	19.70	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.29	0.70	-5.87	51	1064	2012-10-03 02:33:51	2003-08-06 15:25:53	6	9	860	15	263	760	58	389.20	45	85.81	CHANGED	D.-LupLF.cNsaPNTL.........DTTlca...............................................ttspspTFVlTGDIsAhWLRDSosQltsYlslsccDt...........pLppLltGsIspQschllhsPYsNAFpss.......sstput.t.sDps.........p..t................s.hVaEpKYElDSLsh.lpLutpaacpT.G-s........shhssp.WhpAlcpllclhcpppp.................................tpsh.ssYsFpRpTshuo-TLshsGhGsPls..TGLlpSuFRPSDDAolasahIP.uNhahsstLcphucl...ht.tthtsc...................LuppspphupclcpuIpcaGllp..........H.scaGclaAaEVDGaGuthhMDDANlPSLLuLP.hLGals.hcDs........................................................................................lYpNTR+hlLSpp.NPYahcGpthcGIGGPHlGhphsWPMSlllpuhTo.............sD-pEItpsLphlhsosuGhGlhHEShcssss..pcaTRsWFAWANohFuchllc	...........................................t..chsphF.ppsassTL.........-TTVch..................................................c-ssTFVlTGD.IPAMWLRDSoAQl.pPYL......hlAccDs....................pLpphItGllpRQhphlhhDPYANAFN.s.........sht....G.........ap..s.......DcT..............chs..........................s.hlWERKYElDSLCYPlpLAYhhW+pT...Gco......s.Fsp.....p..ahpAhcpILclaphEQc......................................t...t.p.SPYpF...R.....sTs.....p.......tpDTLspsGhGs....sssh..TG.MsWSuFRPSDDACpYuYLlP.SNhFAVVsLthlpEI....hps.lt....h.p.c..p.....................................lstcspcLtcEIppGIcpauhsp.............p..sph.......tcl.YAaEVDGhGs..t..l.MDDu.N.VP.SLL.uhP.YLGass..h-D.........................................................................................l..YQsTR+hlLSpc.......NPYaap..Gp.....hupGIGSsH....................os......h...pYl.WPluLuhp...GhTo.............pD....csEhcphLchLlsoDu.GTGhMHESFc..sssP.....spaTRpW.................FuWANhhFsELllc....................................................................................	2	95	173	226
+6653	PF06825	HSBP1		Heat shock factor binding protein 1	Wood V, Studholme D	anon	Pfam-B_20266 (release 10.0)	Family	Heat shock factor binding protein 1 (HSBP1) appears to be a negative regulator of the heat shock response [1].	24.00	24.00	24.00	24.00	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.72	0.72	-4.39	20	305	2009-01-15 18:05:59	2003-08-06 17:00:52	7	4	201	2	193	288	2	50.70	47	56.10	CHANGED	sp-LosaVpsLLpQhQs+FpsMScpIls+ID-M.......................upRID-LEpols-L..hspsGs-	..........h.p-LTshVpsLLpQhQs+FQsMS-p...IlsR......lD-M.......................usRID-LE+sIsDLhspsGh..........	0	60	94	143
+6654	PF06826	Asp-Al_Ex		Predicted Permease Membrane Region	Yeats C	anon	Yeats C	Family	This family represents five transmembrane helices that are normally found flanking (five either side) a pair of Pfam:PF02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the Pfam:PF02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter ([1]). In  conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalysed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.21	0.71	-4.76	34	4439	2012-10-02 17:06:44	2003-08-06 17:46:47	7	8	1308	0	585	2491	77	168.70	31	61.72	CHANGED	slslslslGhhlGplph......hulsLGsusGsLlsuLllGpht........hshshsthlpslGLslFlhslGlpuGssFhsulpps.Glphhhhulllsllshllshllu+..lhchshshssGhhuGuhTsosulusus-t.sp.shss............luYussYshGhlhhllhs.tllhh	....................lhlslslGlhlGpl.pl..........tulpLGhuhG.....sL.....hsulllGp....h.....t..h.hh..................hs.sh..p...h.lpp...hGlhLFlhsVGlpuGs.sFhs.s.ltps..G....h....phh.hhulllsh.lshlls.hll.u...+...lh........c....h....s....h....s..hhhG..hhuGuh.Tss.PuLuhusst........sp...s...s.hsu................................................................luYAhsYsluhlhhllsspllh.h.................................	0	157	335	485
+6655	PF06827	zf-FPG_IleRS		Zinc finger found in FPG and IleRS	Bateman A	anon	Bateman A	Domain	This zinc binding domain is found at the C-terminus of isoleucyl tRNA synthetase and the enzyme Formamidopyrimidine-DNA glycosylase EC:3.2.2.23.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.82	0.72	-4.26	143	6847	2012-10-03 10:42:43	2003-08-06 17:58:27	9	22	3732	62	1464	4839	1582	29.50	34	5.63	CHANGED	uphC.R..Chph.hpchth..stctshhCs+Cpph	..........Gc.CtR..Ct..s.....h..lpclsh.....ss+sshhCscCQp.....	0	441	915	1228
+6658	PF06830	Root_cap		Root cap	Vella Briffa B	anon	Pfam-B_5867 (release 10.0)	Family	The cells at the periphery of the root cap are continuously sloughed off from the root into the mucilage, and are thought to be programmed to die [1].This family represents a conserved region approximately 60 residues in length within plant root cap proteins, which may be involved in the process.	20.80	20.80	22.50	22.40	18.60	18.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.73	0.72	-4.13	18	153	2009-09-10 23:47:36	2003-08-07 11:46:05	6	5	23	0	81	151	0	55.20	54	17.43	CHANGED	uFKFasLSscVcGVLGQTYRsDYVNp.lcluusMPVMGGsccYtTSuLFusDCsVuRF	......sFKFa.sL..ospVcGVLGQTYRssY.ls....lcluss...MPlM.GGtscYts.SsLFusDCtVuRF......	0	9	43	70
+6659	PF06831	H2TH		Formamidopyrimidine-DNA glycosylase H2TH domain	Bateman A	anon	Prosite	Domain	Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidised purines from damaged DNA. This family is the central domain containing the DNA-binding helix-two turn-helix domain [1].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.00	0.72	-4.23	19	5357	2012-10-02 21:21:44	2003-08-07 11:51:56	9	25	3675	70	1277	3734	2235	91.20	32	32.59	CHANGED	LGP-PL.........p..sh...............t.htptltc...p....+.....+slKshLLDQplluGlGNIYsDEsLFtutlcPpphAssLstpchphlhpslpplLpcAlphstsshph.s	...............................................LGP-PL.............sssh.ss.......................p.h..l..tp.t.l.tp......+......p.................ps.I..K.shLL..DQ.p.ll.....u...GlGNI.......YssEsLap...Atlp.Pp+.....ussL......o......t......t............c......h......p......t......LhpsltplltpulptGGoo....th......................................	0	400	799	1061
+6660	PF06832	BiPBP_C		Penicillin-Binding Protein C-terminus Family	Yeats C	anon	Yeats C	Family	This conserved region of approximately 90 residues is found in a sub-group of bacterial Penicillin-Binding Proteins (PBPs). A variable length loop region separates this region from the transpeptidase unit (Pfam:PF00905). It is predicted by PROF to be an all beta fold.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.98	0.72	-4.06	111	1158	2012-10-03 16:25:20	2003-08-07 12:26:00	7	11	1137	0	250	947	46	88.70	30	12.10	CHANGED	ststts..tts.ss.pIhhPscGuhltls.s..........t........ttplslcstuu.ps.........hhWhl.......sGp.l.spstptcphthts....tsGhapLol..lDssGpssp..lph	..............................ss.s.....ssp.hsLplsusp..-.Gu.hlphhsst.........s................pssLs.lpssGG.su........chaWaL...................NGcsl........s..pp.....s.c.slshph....tptGc..a....pLhV..hD-sGphss..Vph...............	0	69	147	199
+6661	PF06833	MdcE		Malonate decarboxylase gamma subunit (MdcE)	Moxon SJ	anon	Pfam-B_10907 (release 10.0)	Family	This family consists of several bacterial malonate decarboxylase gamma subunit proteins. Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcD and E together probably function as malonyl-S-ACP decarboxylase [1].  	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.39	0.70	-5.16	9	323	2012-10-02 13:07:06	2003-08-07 12:47:24	6	2	311	0	94	1349	480	245.50	37	82.37	CHANGED	shhsuLhss...tpuhsssstVlcGphst.sst.lsVlussN.......putlGl.EuhuLAtsV.-sl....ppts+pPIlsllDssSQthuRR-EhLGIppsLAthupuhshARhuGHslIGLlhGcAhSGAFLAaGhtAscLlALs..Gs.l+sMshsuhARVTphoVEtLcsLAtosPshA.sl-NYsphGhlpthhssppsps.uss.hs.lpp..tt..tDt........pRhsGtpRtupphspclhccsh	.....................................................................hhsuL...h.st.......hpuh..s.s..ss...p....lh..sG..p..h..st...ss+hluVV...ss...sss.h..................RstpGEVG..L.......E..G..as..L..A.......ps..V..-s.l....stcpss..KRPIlsllDVsSQAYGRREEhLGIapALAsuucuYApA.Rh.AG..H..PlIGLlsG+Ah...SG...A.F...L...A...H...G...h.Q...AsRLlALss..Gshl+sMuKtuA.A......R.V..........T.h..R.........o..........V..........-.......pL......E.....p....L....Ap.o.lPshAYs.lcNY........sp.L........GhlpplLs..s......s..s.c.s.s.s.s..st..l.s..h.lppslsp.shtDh................pchtutpRtupthspchhpt.....................................................................................	0	12	40	65
+6662	PF06834	TraU		TraU protein	Moxon SJ	anon	Pfam-B_10708 (release 10.0)	Family	This family consists of several bacterial TraU proteins. TraU appears to be more essential to conjugal DNA transfer than to assembly of pilus filaments [1].	25.00	25.00	29.50	25.80	23.40	24.10	hmmbuild  --amino -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.02	0.70	-5.29	58	720	2009-01-15 18:05:59	2003-08-07 12:50:46	6	3	485	0	138	610	39	276.00	32	88.84	CHANGED	uphlss..hsssshsCl.shplsGhsh.....................hhhC.ss.sshh+sulpluaapPstlVsshpssts.Phltstplshu.....................shsp.tttsssppspssh....sFhpschhuaPhhhhh.shlss...........................................................................................................hsC.ssssh....halSplDsh.Wpssh..thl.....PEAll.Gt.htl..uussuss...................saGslYPhsGh.sspssshpuuullupRhsshlp...R..pshlat..shus................................uhshh..hstPlhc...pppa+aQhlhPhssss......Ctsasposhh.t...spphssss.ssauahlWRhhsCCtt	......................u.thhsslsshthsCl.shpluulph....................hhhC..ss...s.hhh+hultluaapP.tllsshpsPGs.s.lt..hthhshs.............................tstt.s.ssptppcpssh....sFhpschataPh.h.h..hl.shhss.............................................................................................................................hsC.tsush...........lhYLSElDPh.Wpss...h....sthlt............PEAllhus..hs.uAssu-s....................................................has.ts.Gs..hYPhsGa..s.....spssshpuusllupRhsthlp....R...Qshlhp..shut.s......................................uhCh....hssPlh.....+ppa+aQhltPhssss..............................C.pshs.c...oshhht.........sps.s.....s...s.....t....psauahlWRhhsCC...........................................................	0	30	71	111
+6663	PF06835	LptC	DUF1239;	Lipopolysaccharide-assembly, LptC-related	Moxon SJ	anon	Pfam-B_11065 (release 10.0)	Family	This family consists of several related groups of proteins one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membrane by a set of proteins constituting a transport machinery that is made up of LptA, LptB, LptC, LptD, LptE. LptC is located on the inner membrane side of the intermembrane space.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.79	0.71	-4.87	64	2204	2012-10-01 21:43:16	2003-08-07 12:52:59	8	16	2061	1	556	1696	1443	166.70	19	80.55	CHANGED	hllhhllsuhh.hhhhptpsst.........sthpspps-ahspshpsppaspsGp.hpaclpuschc+as.ssst.........shhspPslhhapssp....................WplpuppuplsptsphlpLhssVtlpphtspsp..............hpplpTsphplphpsphhpo-psVplpsssh..thsGhGhcuslcspphpLhspV+...sp.a-	..........................................................................................h..hhh.lhsh...hhh...tt.................ptpp.ssh...h.......pp..hph.h........h.s....p.Gt...h.....pap.lhu.p...c.h.p.hhs...sps.h..........sh.h.p.p...P...h...h..pha.spsp..............................ssh.p.lpAccu..p.lss.....s.p..hlh...L.hu.s.Vplpsh...ttp..............................htplpTc.p...hplshp...s..p...p.l..p..o...-..c......Vp..l..h...s...ss..h......ph......s.G.h.t.hc..ssh..ps..p.phplh.p.pVps..............................................................................................	1	161	349	464
+6664	PF06836	DUF1240		Protein of unknown function (DUF1240)	Moxon SJ	anon	Pfam-B_11130 (release 10.0)	Family	This family consists of a number of hypothetical putative membrane proteins which seem to be specific to Yersinia pestis. The function of this family is unknown.	22.00	22.00	22.00	22.00	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.17	0.72	-3.77	16	192	2009-01-15 18:05:59	2003-08-07 12:54:50	7	2	47	0	51	115	0	92.90	45	71.30	CHANGED	DcIpFSusVhIhhFSsPLlhYhhshulashIpN+hPKapcphs+hLshlAlhShllSFPlSFYVcYKLKupuYlVCsRISWMSPNsYVKDlpLCc	.............DhIhFShtlsl.hlhusPLLhYh.hhuh.ahhI........hN+.........s........KhN...s.hlsphLs...hlAl.luhllSh.hShYlsYpL+ptGYlsC.sRh...S.WMS..P....NpYVKDlpLCc............	1	0	22	26
+6665	PF06837	Fijivirus_P9-2		Fijivirus P9-2 protein	Moxon SJ	anon	Pfam-B_11357 (release 10.0)	Family	This family consists of several Fijivirus specific P9-2 proteins from Rice black streaked dwarf virus (RBSDV) and Fiji disease virus. The function of this family is unknown.	25.00	25.00	30.60	189.80	24.20	22.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.39	0.70	-5.20	3	20	2009-01-15 18:05:59	2003-08-07 12:58:00	6	1	6	0	0	20	0	206.50	68	99.93	CHANGED	MDs.ppSV.hDoYTFpCPFEL...AKIclcuhpNsMp-VoNFsslF-hshSDSElDD+VDsLElcVEcsssPLl+RtYGKVG+IlahIlSFLFFGIFKLVLKhFYHLF+CVhCNPLoRsllSIIFTIlFYhhLhVsIYLLaaFFGDsIIpslNsLNp.cSsNFlNSTQshsuKVEEpVtKIIQsspLlFuppDpNslQpN-KussVsNGsTsNaTLFN	MNP.QSSVNlDTYTFNCPFEL...AKIQIEShKPIMQDFSNFD-IFERsLSDSEIDDRVEpLElDVEuKVDPlVRR+YGKlGHIIlMIISFVFFGIFKLTLKMFYHLFRCVCCNPLIRGIhSIlFTILFYhLlhVsIYhVYaFFGDQI.tsYNoLsphcsSshINSTp.....VEEKVcNIIH-GSLFFGohDpsTGplpElEpQVsNGGTVNYTLFN.	0	0	0	0
+6666	PF06838	Met_gamma_lyase	Alum_res;	Methionine gamma-lyase 	Vella Briffa B, Haft D	anon	Pfam-B_5307 (release 10.0)	Family	This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	405	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.14	0.70	-6.17	14	999	2012-10-02 18:26:03	2003-08-07 13:00:36	6	5	922	20	186	1314	419	385.50	52	96.17	CHANGED	h.plhcpAEtslhshFcplDchschNQh+VLpAFpccRlS-pHFssoTGYGYDDlGRDTL-pVYAcVFGAEuALVRPQhVSGTHAIusALFGlLRPGDELLhlsGpPYDTLEEVIGl+Gp.stGSL+-FGIsY+pVsLptpGclDapslppulp..spTKlltIQRSpGYuhRPShoIs-ItchIphVKplNPslIlFVDNCYGEFlEppEPscVGADLhAGSLIKNPGGGIApsGGYlAGKp-hlEtuuYRLTuPGIGpEsGAohsphp.haQGLFLAPHVVuEAlKGAhhsAtlh-clGasspPpasspRoDlIQulpFsscEKhIAFCpuIQtuSPIsualpP.PusMPGYEDcVIMAAGTFIQGSSIELSADGPlRtPYhuYlQGGLTasHVKlAlhtAlsplh	....................................................................................................h.tlhpclEppltshaccl-ch.s.hNQhKVLpAFpcp+lo..-.pcht.s.o.T.G.YG.Ys...Dh...G...R...Dp....LEcl...YAp..lFtu.E.s.AL.VRPQllSGTHAIuhALhulL...RP...GDELlh...lT...G.pPYD.TL..pEVIG.l............p.Gp..uh....GS.L.t.E.aG.lsYcp..lsLp..-t..Gpl.Dh-sltpsl.p..p.p.T.KllsIQRS+GYu.pRsShsls.............cIcchIs..hl..K.plp...P....s.lllFVDNCYGE.FlEppEPscl.G.AD....LhAGSLIKNP.GG.Gl.A..s.GG.Y.I.s..G.+.c.-.Ll.Et.s...u..Y.RLTuPGIGpEsG..A..oL.s..s.h..p..p..h..YQ........Gh....FLAP....+.V...VupAlKGAlFs..A..t..h..hE.chGh.p.ss...Ppast...R.oDlIQsVpFpstEphIuFCpuIQtuSPlsuahsP.PshMPGYED-VIMAAGTFIQGSSIELSADGPIRsPYtsYlQG.GLTYpHsKlAlhpAlpphh...................................................................................................................	0	77	135	161
+6667	PF06839	zf-GRF		GRF zinc finger	Bateman A	anon	Bateman A	Domain	This presumed zinc binding domain is found in a variety of DNA-binding proteins.  It seems likely that this domain is involved in nucleic acid binding.  It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to Pfam:PF01396.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.49	0.72	-4.03	14	1335	2012-10-03 10:42:43	2003-08-07 13:01:28	7	90	280	0	771	1259	16	45.30	32	10.05	CHANGED	shCs.CG.phshhhssp.sG.NpGRpFYpCPhsc......tCsFFpWsDps	............hCp.C....u..p..s..h..h.hs.sp.p.s..u..sNp....GRp.........FasC..stspt..................ttC..s.FFpWt-........................	0	155	290	523
+6668	PF06840	DUF1241		Protein of unknown function (DUF1241)	Moxon SJ	anon	Pfam-B_11380 (release 10.0)	Family	This family consists of several programmed cell death 10 protein (PDCD10 or TFAR15) sequences. The function of this family is unknown.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.92	0.71	-4.97	6	159	2009-01-15 18:05:59	2003-08-07 13:03:01	6	3	106	19	95	131	2	130.10	42	55.91	CHANGED	hs--ss.lsuh........sL.llhcPlhscLE+.cchs.....AsQpL+sAhhKuEppsPGhohDllssIlc+t..-lsVNhsEolLRhtutss-....EYphsRpEscFpELs+KAtsLKpILS+IPDEIsDR+sFLETIK-IASAIKcLLDAVNpVachlPs....hosKpAlEc	.............s.......hsSh........sL.slhhPlFscLE+..hshu......AAQoLRuAhhKAEppsPGlTpDllhpIlc+t..slplNhsEolL.Rhtusts-....Eahl.pRsE.tFQ-Lsc+uhuLKpILS+IPDEIsDRhpFLpTIK-IASAIKcLLDsVNplhp...hh.......ps+pAlEp.................	0	34	42	70
+6669	PF06841	Phage_T4_gp19	T4_Gp19; 	T4-like virus tail tube protein gp19	Moxon SJ	anon	Pfam-B_11507 (release 10.0)	Family	This family consists of several tail tube protein gp19 sequences from the T4-like viruses [1,2].  This famiyl also contains bacterial members which suggest lateral transfer of genes.	19.20	19.20	19.30	19.20	18.70	19.10	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.57	0.71	-4.53	97	689	2009-01-15 18:05:59	2003-08-07 13:07:47	7	4	303	0	272	645	2092	139.90	19	81.40	CHANGED	ssFpFtVp.h..............ssht..................suFpcloGLshchpshpa+c..Guss......hhh....+hPGthcassloL+RGls...p......spp..lhpWhp......pshpsth........................++slslpLhscsu.p...................l.h.sWplhpAaPs+h...........su.sslsA....susplAlEolcLsa-thp	...........................................................h.F.lp.h..................ss.........................hth..p.pssuhp......hp......hps.hphtp...Gsts............hhh......phs.G...p.hp.a.s.s.l.oLcpslsp........spt.hh.pWhp.............pstssth..p.....................................ccshslpl....h.spss..p.........................................sl.h..paplhsuaP.sch...........ss.ssLsu....sssp.l.shpslplsacth................	1	94	202	251
+6670	PF06842	DUF1242		Protein of unknown function (DUF1242)	Moxon SJ	anon	Pfam-B_11544 (release 10.0)	Family	This family consists of a number of eukaryotic proteins of around 72 residues in length. The function of this family is unknown.	25.00	25.00	25.60	28.20	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.70	0.72	-4.45	32	317	2009-01-15 18:05:59	2003-08-07 13:10:49	7	9	230	0	201	288	0	35.50	49	38.14	CHANGED	LLhVlLLlICTCoYl+thhPullDp....s+.sGhhGhFW	.....LLsVlLLlICTCsYl+phhPullDp..............s+.sGhhGlFW..........	0	63	105	161
+6672	PF06844	DUF1244		Protein of unknown function (DUF1244)	Moxon SJ	anon	Pfam-B_11743 (release 10.0)	Family	This family consists of several short bacterial proteins of around 100 residues in length. The function of this family is unknown.	21.20	21.20	22.70	21.80	20.00	18.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.31	0.72	-4.15	69	402	2009-01-15 18:05:59	2003-08-07 13:15:05	6	6	397	4	128	343	734	67.20	61	61.82	CHANGED	VQNIDLMNLAGFCRNCLS+WYp-AAp-pGlplsc-pAREhlYGMPYs-WKupaQscAosEQhAuFcts	...........VQNIDLMsLAGFCRNCLS+WYpsAA-cpG.l-lshD-AREtVYGMPYsEWKupaQscAosEQhAAFct.p............................	0	37	73	98
+6675	PF06847	Arc_PepC_II		Archaeal Peptidase A24 C-terminus Type II	Yeats C	anon	Yeats C	Domain	This region is of unknown function but is found in some archaeal Pfam:PF01478. It is predicted to be of mixed alpha/beta secondary structure by Prof.	26.20	26.20	28.10	26.90	26.00	19.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.23	0.72	-3.56	21	99	2009-01-15 18:05:59	2003-08-07 13:22:34	6	2	90	2	63	95	11	90.10	24	34.07	CHANGED	hhKchlhhhhGh+hclp................p....hc.cpthhLsptp-.tt.h...hh.hpsh.psssphptplpcatcc....cp..lWVTPGlPFllsIshGalluhlhGDh.l	.............................................................................h......h.h.u..hpht.................t....ht.t.hh.hhptct......................h...h.htshtp.sspphpcthpphscc........cp..lWVoPGlPallslhlGallullhGDhh.....	0	15	39	53
+6676	PF06848	Disaggr_repeat		Disaggregatase related repeat	Moxon SJ, Mistry J, Adindla S	anon	Pfam-B_11958 (release 10.0)	Repeat	This family consists of several repeats which seem to be specific to the Methanosarcina archaea species and are often found in multiple copies in disaggregatase proteins. Members of this family are also found in single copies in several hypothetical proteins.  This repeat is also known as DNRLRE repeat and is predicted form a mainly beta-strand structure with two alpha-helices [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  It is found in some cell surface proteins. 	27.60	27.60	28.30	27.70	27.30	27.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.13	0.71	-4.86	16	49	2009-01-15 18:05:59	2003-08-07 13:26:16	6	15	13	0	31	50	4	168.90	48	32.12	CHANGED	DNRLREuSP-sVap-osaIDlGuhsssG+YRDlhhF-LScYsssspIss....ATLSLYWYYPsspsRPEDTVlElYRPAuuWNPsYVSWNpRDcslsWpNsGGDWYDKNGVLQGSTPYATlTlKGSsLPDNRYYELDVTDLVKEYVSGKYENTGFLIKARoEssNYIAFYSs-sssEsQcPKLsl	....................DNRLREuSP-sVap.sosaIDVGuhsss.+Y...RDlhhFDLSpas..s.ssclss....AsLSLYWYYPs..up..sRscDTllElYRPAou.....WsssYVoWNp+DpslAWpNsGGDWYD+sGlhQGsTPYAolTl+GSpLP.D.N+YYElDVT-LVpEYlSG+YEN...TGFLIKuRsE.ss.NYIA........FYSs-sssEsQhP+Lpl...............................................................................	0	13	14	14
+6677	PF06849	DUF1246		Protein of unknown function (DUF1246)	Vella Briffa B	anon	Pfam-B_5448 (release 10.0)	Family	This family represents the N-terminus of a number of hypothetical archaeal proteins of unknown function.	25.00	25.00	113.00	112.20	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.55	0.71	-4.35	43	187	2009-01-15 18:05:59	2003-08-07 13:58:34	7	1	109	19	117	182	116	124.90	42	35.14	CHANGED	IuTluSHSALpIhcGAKcEGF+TlslCpcuR.-phYpcFs.............hsD-hlll-cap-lh..chtpcLhcpNuIllPHuSalsYlGh-plEs.htVPhFGNRplLRWEs-Rstcpp...LLccAGI+hP+tac	.IuTluSHSALpIhcGAKcEGFcTlslsp.+sR.cthYpcF..............hhD-hlll-pas-ll..chtccLhcpNuIllPptSFlsYl....Gh-plEs.hpVPhFGNRplLRWE.-Rstcpp...LLccAGlchP+ha...	0	29	58	87
+6678	PF06850	PHB_depo_C	PHB_depo_C-term; 	PHB de-polymerase C-terminus	Vella Briffa B	anon	Pfam-B_5697 (release 10.0)	Family	This family represents the C-terminus of bacterial poly(3-hydroxybutyrate) (PHB) de-polymerase. This degrades PHB granules to oligomers and monomers of 3-hydroxy-butyric acid.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.16	0.71	-5.10	11	544	2012-10-03 11:45:05	2003-08-07 14:31:15	6	2	381	0	215	658	140	200.80	49	46.95	CHANGED	GGPIDsRtsPTsVNpLApc+sh-WFcpNlIhpVPhsYPGtGRcVYPGFLQLuGFlSMNhDRHlpAHhDhatcLV+GDG-pA-+HpcFYDEYLAVMDhoAEFYLpTVcpVFpcatLPpGchtpcGphVDhssIpcsALhTVEGENDDISGlGQTpAApcLCsuIPcs+KtaahQsuVGHYGVFsGpRaRppIhPplt-FIcchs	....................................................................GGPI.DsRtsPTsVNpLAp...p+shsWFcpNlIppVPhsaPGtGR+V..YPGFLQhsuFhuMN.-RH.h.puHh-happL.lcGDs.s.sA-tHRcFYDEYh.A.VhDhsAE...aYL-TlcpVFQcatLsp.Gphph...c.....G......c.....h.....VcPssI.+csALhTlEGEpDDIoGsGQTcAApcLCoulPssp+p+ahtsssGHYG.lFsGpR.WRppIhPtlccFIpp.s..............................	0	42	108	152
+6679	PF06851	DUF1247		Protein of unknown function (DUF1247)	Vella Briffa B	anon	Pfam-B_5762 (release 10.0)	Family	This family contains a number of hypothetical viral proteins of unknown function approximately 200 residues long.	25.00	25.00	29.90	194.50	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.89	0.71	-4.55	17	44	2009-01-15 18:05:59	2003-08-07 14:34:31	6	1	39	0	0	43	0	148.50	51	72.01	CHANGED	LGDVlQpMGRp.shLLtc..KKD--FcIspph-LS-ps+-YLNhLQpEKLapCRLCYp+sDph..RC-FH++YlFspstchphD-YVpFLNS-MGllSaVELYYsYLus...ss.W+hsAphhL+cLTsFpSlp-LLsaYNYphspDsDsssaEhMD	LGDVlQpMGRp.phLLpc..KKD.--FcIsEph-LS-ps+-YLNhLQpEKLapCRLCYp+scsh..RC-FHKKYlFccshchtsD-YVpFLNS-MGlISaVELYYoYLus....ss.W+hsAphhL+-LTuFpSlpcLLsaYNYshssDsDpssaEhMD.	0	0	0	0
+6680	PF06852	DUF1248		Protein of unknown function (DUF1248)	Vella Briffa B	anon	Pfam-B_5811 (release 10.0)	Family	This family represents a conserved region within a number of proteins of unknown function that seem to be specific to C. elegans. Note that some family members contain more than one copy of this region.	21.80	21.80	21.90	22.70	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.10	0.71	-5.00	10	63	2012-10-02 22:59:21	2003-08-07 14:38:07	7	2	5	0	60	63	1	176.10	26	53.84	CHANGED	p-slDllhNPs-chlDsaMKhaGNpRhsFK+EDIupW+cSFsDtY+htlhsLKGTs+lItosHslpF+PLsss.c.psahalGhuWIcP-YRG+ssh+lh-shsppct+s.psDNhlApssphupsFW+KhpG...+sDhGH...plhYlSaYchpDhplP-cL-hsG...IsVKNAREVPc+DIlcYDpol	..........................h.tsl-llhNPspchhDpah+...hh.Gp..p.R.hsF+psDlphWppuFcc.YphhhsshKs...............T..........s.....cllussphhpapslp...s.c.tshhhhGhhahsP-YRupsh.h.+.lhsphhhc...hpp.s.ssN.ssu.p.sss...phtp..happhhG...tpchuc....hhYhShYchs-lhlPcs.LshsG...lhlKss.p-VstcDllpYDpsl.................................................................	0	18	22	60
+6681	PF06853	DUF1249		Protein of unknown function (DUF1249)	Moxon SJ	anon	Pfam-B_11475 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.	25.00	25.00	31.30	31.00	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.54	0.71	-4.48	50	853	2009-01-15 18:05:59	2003-08-07 15:20:06	7	1	849	0	120	359	264	119.90	59	83.45	CHANGED	h+Lh+LLPstcp..sp...shphphs......................shph......plcllEso+YToh.............................................lclspptsts..........hhssPplpVRlYHDA+hAEVlsspphp+lcshYsYPNtpMaphDEKhQlNtFLu-WLpaCLcpG.....pph.tsl	.......................QLRRLLP+sDu..sGE.....oVuYQVu............................sspY....RLTIlESTRYTTL.............................................VpIc...QTsPulo.........aWSLPSMoVRLYHDAhVAEVCSSQQ.Ia.RFKARYDY.P.NKKLHQRDEKHQINQFLADWLRaCLAHGAhA..lss.......	0	23	49	86
+6682	PF06854	Phage_Gp15		Bacteriophage Gp15 protein	Moxon SJ	anon	Pfam-B_11759 (release 10.0)	Family	This family consists of bacteriophage Gp15 proteins and related bacterial sequences. The function of this family is unknown	19.90	19.90	20.90	20.70	18.70	19.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.38	0.71	-4.75	9	188	2009-01-15 18:05:59	2003-08-07 15:23:09	6	1	166	0	19	164	6	160.00	27	87.85	CHANGED	pLs-slhchapacsp-YplDLSFcsVL+la-lhcDcplosspKsplslclLh...........ttphhph.cctsplhlcIhppaIsh-p..c-tlphDlcGN.MP.......ptp..pc+hhsappDA-aIaASFhQsYpIsLlcppsK......................LpWhcFpALLsuLs-sThhppIIpIRphEhsp..ptstcERpplhKLKstYpL	..................................................................................................L...h.p.h.htsttatlshsFppslphhplhp.Dp.plst..+h.hhlphhh.......................sh..tp.t...hhh.....hhp...phl.ht....t......c...ss.h.....................t....ppthhshp.Duch..IYuuFhptY.sIcL.hcp.p..sc......................hpWhcFpALhpuLs.-c...T.hppIltIRsh-.sp....ttspc...c+cphpchpphYtL..........................................................	1	12	17	19
+6683	PF06855	DUF1250		Protein of unknown function (DUF1250)	Moxon SJ	anon	Pfam-B_11942 (release 10.0)	Family	This family consists of several short hypothetical bacterial proteins of around 70 residues in length. Members of this family seem to all belong to the order Bacillales or Lactobacillales. The function of this family is unknown.	21.10	21.10	21.50	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.19	0.72	-4.44	47	1637	2009-01-15 18:05:59	2003-08-07 15:27:40	7	2	984	4	102	381	1	46.20	35	64.48	CHANGED	hAspsapDpsFPKpspcacclSsYLEh.susah.shssFDcuaptY.	..LA-hhhcDtuFPKpscc.....acplpsYlcp.ss.....shp.shsshDchaphY....................	0	20	45	79
+6684	PF06856	DUF1251		Protein of unknown function (DUF1251)	Moxon SJ	anon	Pfam-B_12000 (release 10.0)	Family	This family consists of the N-terminal region of several hypothetical Nucleopolyhedrovirus proteins of unknown function.	19.80	19.80	20.30	23.70	18.00	17.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.72	0.71	-4.61	20	50	2009-09-10 22:02:51	2003-08-07 15:30:53	6	1	41	0	0	50	1	118.40	34	54.34	CHANGED	chslssKs+sshh+a.................KVplplss..sscalQATFsstpcpVslVN.psppc.IlFDGFsc..-DEutTsPFlV.GsLhul....pspp.hthpVRchscAhEs.pTlL+lFlNEAhl..psshss	................hslss+s+pshh+a.h...............+Vhlpl-u...sspalQATFpst..pcpVslVN.psppp.lhFDGFsc...-DEupThP..Fll.usLpsl.....pssp..shcV+-hscAhEp.sThL+lFlNEAhl..tsph.s.............	1	0	0	0
+6685	PF06857	ACP	MdcD;	Malonate decarboxylase delta subunit (MdcD)	Moxon SJ	anon	Pfam-B_12010 (release 10.0)	Family	This family consists of several bacterial malonate decarboxylase delta subunit (MdcD) proteins.  Malonate decarboxylase of Klebsiella pneumoniae consists of four different subunits and catalyses the conversion of malonate plus H+ to acetate and CO2. The catalysis proceeds via acetyl and malonyl thioester residues with the phosphribosyl-dephospho-CoA prosthetic group of the acyl carrier protein (ACP) subunit. MdcC is the (apo) ACP subunit [1]. The family also contains the CitD family of citrate lyase acyl carrier proteins.	25.10	25.10	26.20	26.00	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.80	0.72	-4.07	40	1378	2009-01-15 18:05:59	2003-08-07 15:34:27	6	3	1149	0	198	624	11	86.00	40	84.14	CHANGED	cIpcsAlAGTLESSDl.VplsPu.s.sslplplpSs..Vt+QFGppIcpllpcsLpphuVpssplplsDKGALDCVl+ARlpsAltRAsc	.........cIppsAlAGTLESuDlhIpltPhps..p......s...........l..clplsSS..VpcQFGctI+pslh-sLs..+hsVpusplslcDKGALDCll+ARlpsultRAu.t..........	0	44	96	143
+6686	PF06858	NOG1		Nucleolar GTP-binding protein 1 (NOG1)	Vella Briffa B	anon	Pfam-B_5853 (release 10.0)	Family	This family represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). In S. cerevisiae, the NOG1 gene has been shown to be essential for cell viability, suggesting that NOG1 may play an important role in nucleolar functions [1]. Family members include eukaryotic, bacterial and archaeal proteins.	20.90	20.90	20.90	22.30	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.76	0.72	-4.09	25	503	2012-10-05 12:31:09	2003-08-07 15:51:30	9	15	386	1	340	554	80	57.60	51	10.12	CHANGED	sIEhQAIsALsHLpuslLFlhDhScpCGY...olcpQhcLacpI+slF.spPlllVlNKhD	............sIEMQuITAL.AHLRus.lLYhhDlSEQCGa...olcpQl.pL.Fcs.I+PLF....s....N.K...P....lllVhNKsD...........	0	115	195	278
+6687	PF06859	Bin3		Bicoid-interacting protein 3 (Bin3)	Vella Briffa B	anon	Pfam-B_5564 (release 10.0)	Family	This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation [1]. Note that family members contain a conserved HLN motif.	21.00	21.00	21.20	21.10	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.38	0.72	-4.07	5	294	2012-10-10 17:06:42	2003-08-07 16:17:37	7	11	155	6	192	292	6	98.80	41	22.77	CHANGED	cFDVILCLSVTKWVHLNWGD-GL++hFRRIYppL+PGGlLILEPQuWDSYcKR+KlSEslppNYpsIcl+PDcFpcaLlsscVGFpohE.LsulssusSKGF.cRPIhlFpK	............paDllLCLSlTKWlHLNaGDpGLpphFp+laphL+s...........G..GhLllEPQsWpsYp...+t....c....p........h...s............c.......p...h....h....pp....a.plp......h...hPp...p..F.t....phLht....l.GFt................ht................s.....h.pR.l.hh............................................................	0	71	95	146
+6689	PF06861	BALF1		BALF1 protein	Moxon SJ	anon	Pfam-B_12069 (release 10.0)	Family	This family consists of several BALF1 proteins which seem to be specific to the Lymphocryptoviruses. BALF1, inhibits the antiapoptotic activity of EBV BHRF1 and of KSBcl-2 [1].	25.00	25.00	27.50	27.10	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.05	0.71	-4.86	2	16	2009-01-15 18:05:59	2003-08-07 16:34:37	6	1	13	0	0	16	0	171.80	39	88.56	CHANGED	M.....TDsVF.cs......APs.ss-DchscushLhhRsMhAsahpD..pGLsh.thlhhRLIKt.hKK-cKhaA-lsspsus.sshHuHlphlhohhRAlY-DHhD.W.RlRslhshsVsaAhRNh.sDpEsAuhlLsuhAcaLsLYRRhWhuRhGGh.huLRRtFPlpWhhhtls..hhp.	.............................................clucoS.lhh+shaAVho.pD..c-.LslsttVLscLlKtSl++sh+las-.Lssps..uchuuccs+lphlhsllRtsYsDphD.apRLpssLsYsslahshsh.sDpcssuhVhsslA+ahshaRphWhuRlGGhspuLR+pFPspWshspLp.aLpp.h......	0	0	0	0
+6690	PF06862	DUF1253		Protein of unknown function (DUF1253)	Vella Briffa B	anon	Pfam-B_6227 (release 10.0)	Family	This family represents the C-terminal portion (approximately 500 residues) of several hypothetical eukaryotic proteins of unknown function.	19.10	19.10	19.10	19.10	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.50	0.70	-6.08	36	368	2012-10-05 12:31:09	2003-08-08 10:01:07	7	4	289	0	255	543	41	379.60	36	61.37	CHANGED	KoRs+llKNsp+Lpcptp................t-.-hRDQGFTRPKVLIllPhRssAhchVph.Llplhss...............pphcN+p+FpcpF.......ppptss............ppK.....PcD....................applFpGNsD.DhF+l.....GlKh..o+Ksl+LY......SsFYsSDIIlASPLGLchllps...........................................................sp......KKc-hDFLSSIEllllDpschl.MQNWpHltplhcalNphPpc.t+s.sDFSRlRhWhlsspA+haRQTllhosa.sPphNSlhsppstNhpG+l+hpshhpt.....................................uslsp.........lslpl+QhFpR..hc........usSlhsssDsRFcaFsssllPplh........sshtsssLIalPSYhDalRlRNYh+..........ppsloFusIsEYosppclsRuRphFhpG+tplLLhTERhHaa+RYplKGl+pllFYu.Pp.PpFYsEll.phlstost...............hc.s.ssspslYSKaDuhpLERIVGscRAsphlpup.pc...sapF	..........................................................................shll+sstpltt.t.t.....................p.-hRDQGhTRPKV.LlllPhRpsshchVph.lhp..lh.s.......................p.ps+pRF.ppas...........tts...............................+.....PpD..........................apt.lF..t.G..N...D...DhF+l.....Glph............s++o.......l+la......utF..YsSDIllASPLGL+hhltt................................................................ttt...........+cp-hDF.L.S....SIEllllDpA-hh.hMQ.NW-Hl.....hlh.p.plNh.Ppc.....tHs..sDhuRl.R..WhLss.u+ahRQTllhosh..s.sp.hsulhs.p....h...sh.....NhtGplphps..t........................................................usltp.........lhl.pl....QhFpR..hc.........sps.hh.p..s.D..s..RFpaF...sp.....pl..l.Pphh...........ss..stsLIa..lPSYhDaVR...lRNa.hp..........ppplsFstIsE......YoptpplsRARphFhpG.c..tphLLhTERhHaa+RYp.l+...G..l+pllaYthPp.PtFYsElh.sh.lttstt.....................................tthsspsla.o+aDshpLpplVGspRstphhpsp..tssa.F............................................................	2	101	152	218
+6691	PF06863	DUF1254		Protein of unknown function (DUF1254)	Vella Briffa B	anon	Pfam-B_5911 (release 10.0)	Domain	This family represents a conserved region about 130 residues long within hypothetical proteins of unknown function. Family members include eukaryotic, bacterial and archaeal proteins.	22.20	22.20	22.20	22.30	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.93	0.71	-4.31	340	950	2012-10-01 20:00:45	2003-08-08 10:59:30	7	11	469	9	332	860	184	127.90	25	28.84	CHANGED	hNphhphp.thhs.tp..pslls...sNsDTlYohuhlDL.pssPlllplP.s.h.s.Rah.shtlhDhappsh.....................h.....st........ststuGp.ah..l.ssPsa...........................................ts.p.......................hh...cusTshshllhRshs......ps.ssD..hss.l.....pt.lQcthp..lts	..............................sph.hhp.th.sssp...pslss.sNsDTlYohualDL.sssPlllplP.s..h.t.RahshthhDhappsh................sshst..........stspuGp..al.l.ssPsa........................pG.h...........hh.hhcssTphshlhhRshh......ps.spD...hts.s.pt.lpcthplh................................................................	0	80	165	252
+6692	PF06864	PAP_PilO		Pilin accessory protein (PilO)	Moxon SJ	anon	Pfam-B_12430 (release 10.0)	Family	This family consists of several enterobacterial PilO proteins. The function of PilO is unknown although it has been suggested that it is a cytoplasmic protein in the absence of other Pil proteins, but PilO protein is translocated to the outer membrane in the presence of other Pil proteins. Alternatively, PilO protein may form a complex with other Pil protein(s). PilO has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body [1]. This family does not seem to be related to Pfam:PF04350.	22.50	22.50	22.70	25.40	20.70	22.40	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.40	0.70	-6.12	9	257	2009-01-15 18:05:59	2003-08-08 11:01:29	7	1	201	0	33	208	3	375.10	26	91.58	CHANGED	salAGLcWpshsp.tp+ssRphu+s.........tsAshhluhphtspptpuphphsuhls....h.httpphaSLAhhhLshhtssGYGIapLspt....pahFlAsssGl.ushuDlVGotsplhpAhppFLshN.sPpp............uWpshusspassshpohstsLSs.....pthRts+LstVtps.phhhhullhlLhuhhh.ua.happ..scsthhststphtActph..ptss.s.....ls.PWAshP.hssFLptChslhpslPVolAGWRhshucCss-G....lRhpYpthsGuTlscFupRlp-la..sppPsFsLs-GuppGslhlPhshp.sppshpsEslPssusQl.+hsSahQphplplslsElpss.shst.Dtps....hP...W+EYsFphpTplsPctlhs..phs-sGlRhsSlshpLps.GpFpYphcGpl..YAp	................................................................................................................ahssLpWp.hst....t....p......pp.....t+.t..........shphhh........ttp..tphhh.suhlt....................thpth..aSLAhhhts...hp...s.....h..hu.........l..apl...s-t.......chhalAsh.sG..t....sh..u..D.lsGs.pp-l.t..pth....ph.ahshs...t.s.t..............tW.p.lh......p....s...c.hs..s..s...p....p..h...t.t..Lss.....................tp..+hs.....pLs.....l....t.p...ptph..hhs..ul....l...h.h..l..s...s..s.u.hs.s.a...a..p.p.p..t...c...s..h..h...s...t...stph.t.Actph.t....pp.s..p.s.s........ls..P.Wss.PshssFl.cuCss...h...h.pt.P...lult.G.W+hstupCssps.....hphhYpp..tsu...uTh..t..sF.t....pscpla......sshPshsl.sG.p..usl.shsl.....s.shs.ht.D-sls.ssp..l.clhoh...hQphpl..p......t.l..s.....E...h....s.........s......s....hss.stps.............P..pW+paphsh.p........osls.P.p.tlh...hhp....t.sGlRlpplthplpt..uphpap.pGplYup..........................................................................................................................	0	10	18	24
+6693	PF06865	DUF1255		Protein of unknown function (DUF1255)	Moxon SJ	anon	Pfam-B_12498 (release 10.0)	Domain	This family consists of several conserved hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown	25.00	25.00	38.90	38.10	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.04	0.72	-3.72	85	1071	2012-10-10 13:59:34	2003-08-08 11:06:28	6	2	1050	2	221	522	128	93.60	55	95.56	CHANGED	hhcsNhYFDGpVpShuhphs-hscpTlGVMhPG-.....YpFuTutsEhMplluGshpVpLPGps.....cWpsasuG-sFpVsANSsFpl+Vp...psosYlCpYh	.....MlpuNpYFsGKVKSIGFspussG+ASVGVMs.GE.....YTFuTupPEcMTVlSGALpVhLP.sss.....-WpsapAGpsFsVPGpScFcLpVs...E.sTuYLC+Yl................	0	53	122	175
+6694	PF06866	DUF1256		Protein of unknown function (DUF1256)	Moxon SJ	anon	Pfam-B_12377 (release 10.0)	Family	This family consists of several uncharacterised bacterial proteins which seem to be specific to the orders Clostridia and Bacillales. Family members are typically around 180 residues in length. The function of this family is unknown. These proteins are related to peptidase family M63 and so may be peptidases.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.94	0.71	-5.05	13	439	2012-10-01 20:58:29	2003-08-08 11:11:13	6	1	326	0	117	354	6	163.40	45	84.31	CHANGED	hlphs-tpAhhpltshLppal.......scclVllCIGTDRssGDuLGPLVGphLKphphs.hpVYGTLc-PVHAlNlccplccIcKcapsPaIIAIDACLGcs..pslGcI.lcstPlcPGpuVsKpLPsVGDlSIsGIVNlos.hEah...lLpssRLphVhchAcsIupu	.......................h..hpp..u.tplssh...Lhshl..h........ppsl.lllC..IGTDRSTGDuLGP......LV.Gop.L.......cp.....h...t.h...s..p...h...pV.aGTL...-c.....P....VH..........A..........h..........N...Lc.............-...plppIpp....pas.ssaIIAlDA.CLGch..ps..l..G.p.IplupGPl+PGuuVsKcLPsVGDlpIsGIVNls..Gh.hE..ah...VLQNTRLslVMcMA-lIup.u.........................	1	58	95	104
+6696	PF06868	DUF1257		Protein of unknown function (DUF1257)	Vella Briffa B	anon	Pfam-B_5975 (release 10.0)	Family	This family contains hypothetical proteins of unknown function that are approximately 120 residues long. Family members include eukaryotic and bacterial proteins.	21.00	21.00	21.90	21.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.24	0.72	-4.14	40	175	2009-01-15 18:05:59	2003-08-08 11:32:11	6	1	109	0	65	168	172	102.10	35	80.65	CHANGED	pALpDLGhphcp.sp.ptVRGY..cGQT.hpA-lsl...p.ssuhDIGFpWNusp..YELVsDLphWp..Qslsl-cFLsploQ+YAhpolLspospp.....GFplsEpppspDGSIcLV	.........................uLpDLGl...shcp...tp..tsVRGY..pGQp..hpA-lll....p.s....ssYDlGFphNuss..Y-Llu.D..hWp....pphshppFl..splsQ+YAhpplLscsppp.....GapssppppttsGshpl................................	0	19	47	63
+6697	PF06869	DUF1258		Protein of unknown function (DUF1258)	Vella Briffa B	anon	Pfam-B_6065 (release 10.0)	Family	This family represents a conserved region approximately 260 residues long within a number of hypothetical proteins of unknown function that seem to be specific to C. elegans. Note that this family contains a number of conserved cysteine and histidine residues.	26.50	26.50	27.30	26.90	26.30	25.40	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.70	0.70	-5.30	3	40	2009-09-13 14:59:23	2003-08-08 11:37:06	7	5	6	0	40	38	0	189.30	29	31.56	CHANGED	AEEARKLWpYsKNNFSTHsYCNtCGK.VLuspcKCNhCssuPVATFVRIGuFSQI+ELVEoYlD-ILEIREQLKsGRNl-HNLuSPFFS+aWcsESpNHL+LSTVlSIDGV+ISGNKKKLWPVSLlLVDLPoGLMQKSTNlILEGIVECSENPSTsLWNALIPhIhSDVEuHoGRV+NITFoC+ITTCSADQPAKRAFFGF+uHSSuhSCFFCLSPETLYK+GGssRKEpRPGaLTIlDScNGcNGFosKsSKIV.HVl	............................................................t.Ch....tp.t.t.......s..............s....t............t.hhpa..hRhshhtQl.pllptah.cIhpl+cpLppupphpHsLsu.ahp.chht..p.E..pt.ptL.plohl.hulDGlpl...tG.s.p....pKlWPlohhllDLPsu.MQ+ssslllpulhEsppsPSThlWNtlhshlhsDhptt.ttlts.hphphhIho.hsuDQ.....P................A.....+R..shauh+uHpup.SC.ashs.tThhKhts...................................................................	0	4	13	40
+6698	PF06870	RNA_pol_I_A49		A49-like RNA polymerase I associated factor 	Finn RD	anon	Pfam-B_20222 (release 10.0)	Family	Saccharomyces cerevisiae A49 is a specific subunit associated with RNA polymerase I (Pol I) in eukaryotes. Pol I maintains transcription activities in A49 deletion mutants. However, such mutants are deficient in transcription activity at low temperatures.  Deletion analysis of the fusion yeast  homolog indicate that only the C-terminal two thirds are required for function.  Transcript analysis has demonstrated that A49 is maximising transcription of ribosomal DNA [1].	20.10	20.10	20.20	22.00	19.00	20.00	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.15	0.70	-5.89	24	337	2009-01-15 18:05:59	2003-08-08 12:05:22	7	10	258	10	242	330	1	321.60	20	82.87	CHANGED	psspsscFsLYKcc..........p..pschllpGE.s-+LcYsGps.ssss.ps......cYhVGlaD.popplclapA.hhsh...........cssscsccshct.thcp.sss+shppR.suLGEAFGT+K......uK+AlsshccN+lc........u-pLpcsthcls-sltpsstshsspp-h.p.sssss..+PhP.sNl-AsslE-lYsl-sIIspcEashlc.lsshltppcspccLp.hhP..sp.upaVtc+L............................................tpLtptpsh.....c+lplLaYlSlLlslhpp.........RplppKpsLhp+ht.....sP-lllsslLc+FThsp.....pstphphhI..ssppc-KLlsYllslhLHlc.sFhV-lssLu+-Lslcss+lhpla+slGsplKt.s.sphpthulscussssaKlAoL+lPh..+hPchpcct...+R	.............................................t..............................ptphlltup.ptplpahupp.t..t.t...............pah...lulhs.pstphp.lh.s...thh.h........................................t...ttp....t..........t.....t.ttp.htt+....ptLhpsF.GopK......t+.+sl...ps.hp..Nt....ls...............................sp....t....h.....p.....t.....s....t..thh........p....s...h............p.s...p...t..s.......s..........pph.t......t.pts.....p.lP.hshsAs..psp-lY.hcs................ll..s..t....t.....h.p..h..lt........t..h......tt.tt...tptl..........t...spalh....ppl...............................................pt.l.........t...........tp......t...........pp......hph...lhalph..Llthhtt.......................................+ph..+pt..hhtt..............................hPchl.ptlhppFss........................p....hh...stp.tshlhsahhslsLhl............s....sa...t.s...-...hssLtp..-L..p..hp...pphhphh+tlGsplpt..................................tt.tthc..hupLtlPh....hPt..tptt...................................................................	2	81	127	193
+6699	PF06871	TraH_2	DUF1259; 	TraH_2	Moxon SJ	anon	Pfam-B_13298 (release 10.0)	Domain	This family consists of several TraH proteins which seem to be specific to Agrobacterium and Rhizobium species. This protein is thought to be involved in conjugal transfer but its function is unknown. This family does not appear to be related to Pfam:PF06122.	26.30	26.30	27.30	31.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.22	0.70	-4.88	8	33	2012-10-03 00:09:25	2003-08-08 12:48:21	6	1	21	0	11	38	0	194.50	55	98.47	CHANGED	MLDAALIKcCADPSLKPAIVEQFlsuAGSsDPLAVTV+SGsRllLVPKsTTsDEAMAlIRQalGpslVRVGLTQaPAGVGVp-Au-LKPDLVDACENlRhGTAhFAKVhRIVsKWYGNPTucDVhPQlF-DAlhAWKTG.FEGluVFpA-DPGsussspssstss-cs.pscsouc.ssustssspsups.s-ss+AGIRIDLStIGu	.MlDAALIcpCADPuLKPAIVEQFlttAGSsDPLAVTV+SGsRllLVPKspTsDEAhuLlRp.lG+s.lVRVGlTQaPAG.lGlh-AupLK.sDLVDsCcNlRhGTALFAKVhRIVsKWYGNPTsp-VhPQlF-DAIhAWpTGhFEGsuVF+A-DPGsss....hspssstpptps.tppsssp.tsus..s..sstsups.sDsspAGIRIDLStIGu.........................................................	0	1	4	8
+6700	PF06872	EspG		EspG protein	Moxon SJ	anon	Pfam-B_13549 (release 10.0)	Family	This family consists of several EspG like proteins from Citrobacter rodentium and Escherichia coli. EspG is secreted by the type III secretory system and is translocated into host epithelial cells. EspG is homologous with Shigella flexneri protein VirA and can rescue invasion in a Shigella virA mutant, indicating that these proteins are functionally equivalent in Shigella.  EspG plays an accessory but as yet undefined role in EPEC virulence that may involve intestinal colonisation [1].	25.00	25.00	69.10	69.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.04	0.70	-6.12	4	134	2009-01-15 18:05:59	2003-08-08 12:57:48	6	1	111	10	1	57	0	370.00	72	98.16	CHANGED	cShhhNuhpNsSA.hsL-uslcVsSshcpsWs-hohAE+LLKlLohGlasPcYotsERpphpcLLolLcPlhPtsNEhG+VtApFSDGSSLRISVTpSE.IEsplpTP-s-Kl.olhLEuNEQNpLLpSL.PlshHMPYIpsH+uLsph-lsstpuM+pLlsFsuKLSTolIPasspTcPLSGsTPFsSlahDThRGL.....GNoKlSlNGV-IPtcAQtLLpstLGLKDTtSSPspNlIppGIshcpAppIlpcSpssp-.....QKAhlsshLCpPEhsoAICSAFYQSFsVPAhhLpH.RIphASpa.upRSLshP..............NAsl...sIuISpSSsGulaVoSpsGshIMAPc-RsNtlGhhT.RTSYEVP.Gs+Cp.sEhsRslpP..+YuuSEsY.pN	.......MINGLNN..sSASLVLDAAh+VNSsFKKsWs-MSCAEKLLKVLSFGLWNPTYoRSERQoFQELLTVLEPVhPhPNELGRVpApFSDGSSLRISVTNSELlEAEIRTs-NEKI.olLLESNEQNRLLQSL.PIshHMPYIQVHRALSEMDLTDssSMRNLLuFTSKLSTTLI.PHNsQTDPLSGPTPFSSIFMDThRGL.....GNAKLSLNGVDIPssAQKLLRDALGLKDTHSSPsRNVIspGISRHcAEQIARESSGSDc.....QKAEVVEFLCHPEAATAICSAFYQSFNVPALoLTHERISpASEYNuERSLDsP..............NACI...NISISQ.SSDGsIYVoSHTGlLIMAPEDRPNEhGMLTNRTSYEVPQGVKCpIDEMVpsLQP..RYuASETYLpN........	0	0	0	1
+6701	PF06873	SerH		Cell surface immobilisation antigen SerH	Moxon SJ	anon	Pfam-B_13151 (release 10.0)	Family	This family consists of several cell surface immobilisation antigen SerH proteins which seem to be specific to Tetrahymena thermophila. The SerH locus of Tetrahymena thermophila is one of several paralogous loci with genes encoding variants of the major cell surface protein known as the immobilisation antigen (i-ag) [1]. 	22.00	22.00	23.60	22.10	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.07	0.70	-13.87	0.70	-5.85	11	200	2009-01-15 18:05:59	2003-08-08 13:01:24	6	9	2	0	192	207	0	156.00	17	99.89	CHANGED	MpsKsLlICLll.......pphhlSVhSshsGssVsCss..ssssCssosssssPshtG.....CSW...........sGsssssCtIsDCsClsss...ssoGLTDhFCpSCtuss......ssaANsAGoACVuoSuSCssspps.....sWssuDCsLCsPsTPAhsut.......uCsACSu.....hoSuaTDusCsACuo...............suoshspslFANoAGouCVAuSASCsSsSRuss...AWTsuDCthCsPso......Phhsus.p.sssoSCsusossToGhTDupCNuCu...................ssuSssspslFANsAGSuCVAoSAoCsouspuss...sWTsuDChhCsPsTPuh...hu..ssooClA......Csuhoos.WTDAsCsuCh.sASsssps...............lFAsusGSuCVAuohSCNtosRuSNpWTDuDCALCNG............................Tuss.uNQYASuDGSSCQuTp......sSuThSuphhlShLLlhSuLLI	....................s.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	192	192	192
+6702	PF06874	FBPase_2	Firmicut_FBPase; 	Firmicute fructose-1,6-bisphosphatase	Moxon SJ	anon	Pfam-B_13194 (release 10.0)	Family	This family consists of several bacterial fructose-1,6-bisphosphatase proteins (EC:3.1.3.11) which seem to be specific to phylum Firmicutes. Fructose-1,6-bisphosphatase (FBPase) is a well known enzyme involved in gluconeogenesis [1]. This family does not seem to be structurally related to Pfam:PF00316.	21.50	21.50	21.60	21.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	641	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.95	0.70	-6.48	33	868	2012-10-02 19:15:56	2003-08-08 13:13:26	6	1	816	0	91	645	36	621.00	51	98.14	CHANGED	h+YLcLLScpaPTlspsuTEIINLpAILNLPKGTEHFlSDlHGEYEAFpHVL+NGSGsl+cKIcDlFu.ssLscsEKppLATLIYYPc-KL-ll+p..ppc.slc-WY+hT.....LhRL....Icls+hsuSKYTRSKVRKALPc-FuYIIEEL.Lacpsctss.KcpYYspIIpoIIclscA--FIlAluplIQRLVVDHLHIVGDIYDRGPts-hIMDpLh...pYHSlDIQWGNHDlLWMGAAuGscsClANVlRIusRYuNLshlEDuYGINLhPLAsFAhchYp.csPC.sFpPKh...st.phsppEhphls+hHKAIuIIQFKLEuplI+R+PEFcM-cRhLLc+Isa-cuTIsL.sG+pYtLpDTsFPTlDPpsPYcLTpEEc-ll-+LhtSFhsSEKLp+HhcFLhsKGuhYLhYNuNLLaHGCIPLsEDGshcphpI..tGcpYpG+pLLDhh-phlRcuah.pcspppcchupDhhWYLWsGtsSPLFGKccMTTFERYFIpDKpTHpEpKNPYYpLR-cEclCcpILcEFGLss....cpuHIINGHsPVKsppGEsPIKANGKllVIDGGFSKAYQppTGIAGYTLlYNSYGhpLVoHpPFpSpccAIpctpDIlSsphllEpsspR+pVpDTDlGpcLppQIpDLctLLtAY+pG	................................+YLcLLuppasohpchuTEIINLEAILpLPKGTEHFlSDlHGEYEAFpHVLRNGSGsl+pKIp-lFt.spLsppEhs-LssLlYYPE-KLpLlcp....ppp..p..h.psWYhhTlp+L....Iclh+hsSSKYTRSKVRKALPcpasYIIEEL.Lacss.c.h..ps.Kc.sYYppIlpplIplppA--a...IluLuhhIQRLllDHLHlVGDIYDRGPtPDpIMDpLh...sY.H..S..lDIQW..GNHDlLWhGAhuGScsClANllRIsARYsNL-llEDuY.GINLRPLhsaAtchYp...s-s...tFpPKht..tpp..phsppE.p.ls+hHpAIulIQFKLEstlIcRRP-FcM-cRllL-KIsa-pssIs.l.pGp.......pYsLp....DosF.Tl.....s.....s....csPhcLstEEc-lhs+LhhSFppSEKLp+HhpFLhpKGShYLsYNuNLLhHGCIPlsEsGphcshpl..p.G.c.p.Y.sG+pLLDhh-hhlRcua.....s...pt........p....p....pc....chusDhlWYLWsGchSsLFGKctMoTFERYFIs..D......KtoH+EcKNPYYp.L..R..-.ct..p......hsc+ILcEFGLss....-puHIINGHTPVKphcGEsPIKAsGKhlVIDGGFSKAYQppTGIAGYTLlYNSaGhQLVuHpsFsupEcslpps.tDhhSh+pll-p.phpRphl+DTshGccLppQIptLchLhcsh..t......................................................................	0	39	65	82
+6703	PF06875	PRF		Plethodontid receptivity factor PRF	Moxon SJ	anon	Pfam-B_13241 (release 10.0)	Family	This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity [1].	19.40	19.40	19.50	19.70	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.30	0.70	-5.12	2	260	2012-10-02 01:28:15	2003-08-08 13:18:57	6	1	58	0	45	239	0	204.80	59	94.64	CHANGED	RSTSLLTFLVVSLSTATSLAMAEINDVADLSSDTIVhFSEVQKFAEDIQSSADSLLPTYLSFQGAPLSDPDYQLPHIKVsNLPTAAMDYDTFh+QTDETRLpNNLYFYSAIVEFLKEAMTEQEDLNPAELuLKAKFEEAMANSNTLISKISDIMTQMGMSVTITLPKPLVVPFcGSAYFpKKLRGGVVCKEYKERVhLTKRDF.hLAcKYQG.L	............................................RSTuLLTFLVVSlSoATSLsM......A......-hs......DVA-LSpDTIVLFSEsQKFAEclQSsADSLLsTYLSFQGAPLSDPDYp....LP+.IK.V.s.NLPTAsM.DYDTFhpQTDEsRLpNNLYFYSAIVEFL+tAMTEQE.DLNPAELuLKAKFEEAMANSNTLISKISsIMTQMGMS...V.....TITLP..c..PL.V..VP..F...c.G.SAhFpKKLRGGVVCKEYKERVhLTKRDFphLAcKYQG.................................................................	2	1	4	13
+6704	PF06876	SCRL		Plant self-incompatibility response (SCRL) protein	Moxon SJ	anon	Pfam-B_13253 (release 10.0)	Family	This family consists of several Plant self-incompatibility response (SCRL) proteins. The male component of the self-incompatibility response in Brassica has been shown to be encoded by the S locus cysteine-rich gene (SCR). SCR is related, at the sequence level, to the pollen coat protein (PCP) gene family whose members encode small, cysteine-rich proteins located in the proteo-lipidic surface layer (tryphine) of Brassica pollen grains [1].	21.80	21.80	21.80	22.00	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.14	0.72	-4.01	43	154	2012-10-01 23:31:40	2003-08-08 13:22:27	7	1	12	1	49	160	0	65.60	27	86.40	CHANGED	Fll....SHsQ.-VEAshh........C..tppsasG.pCussGscp............Chpphpp.....hcpcshpCpCs......tthpsp+hCsC..ph	......................hp.-VEA.shhpt......C...tp..tt.hs.G.pCu..ssGs.p.p............Chpthpp.......hpppshpCpCp.........t.pppphCpCp.h..............	0	25	26	28
+6705	PF06877	RraB	DUF1260;	Regulator of ribonuclease activity B	Moxon SJ, Bateman A, Eberhardt R	anon	Pfam-B_13601 (release 10.0)	Domain	This family of proteins regulate mRNA abundance by binding to RNaseE and inhibiting its endonucleolytic activity [1-2]. A subset of these proteins are predicted to function as immunity proteins [3].	23.30	23.30	23.30	24.80	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.79	0.72	-3.38	67	1287	2012-09-25 12:41:39	2003-08-08 13:24:37	6	5	1101	1	189	635	25	103.70	42	67.55	CHANGED	h.pppspcllptLhcsGs.-.st.a.lEaahhhsc.cphcchutchhptGac.lps.tp.............-c.ss..shathphstphhhshctIsptpppl.plApchssp.YDGWGs	.............Qc-ETR.IIcpLLEDGS.DP-uLYsIEHHlss.cDh-sLEKAAV....-AFKhGYE.Vs-sEEh.........EsE-Gc....hlhssD.lhs.Ess...Lss-hIDuQV-pLhsLAEKassp....YDGWGT...................	0	32	79	135
+6706	PF06878	Pkip-1		Pkip-1 protein	Moxon SJ	anon	Pfam-B_13784 (release 10.0)	Family	This family consists of several Pkip-1 proteins which seem to be specific to Nucleopolyhedroviruses. The function of this family is unknown although it has been found that Pkip-1 is not essential for virus replication in cell culture or by in vivo intrahaemocoelic injection [1].  	25.00	25.00	116.10	115.90	24.30	19.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.69	0.71	-4.36	19	40	2009-09-14 12:00:35	2003-08-08 13:28:33	6	1	39	0	0	37	0	162.40	33	93.32	CHANGED	stIcphpsK.NslhcQa-pKVhsahpKss.s................-sttp-hhhLuAplaG.pEQL.uLpp..ssscpc+.h-FlsDl.s-L.Dhssp-lcphhptsc.s......ahhpKYpssph.pthppsac.p..pFlKhhcpFlsKRps.h.............hp........sss....sshL-ELVhLKsslIKHLCshEpLs	....pIcplpsKcsslpcpY-pKVhsah+Kss..................-stts-hhhluAplaGhcEQLhuLpp..stsccc+.l-FlsDl.s-L.Dhss--l-plhttps.s......hlspKYpssp.l.....scslppsa-pptppFlKllcpFlsKRss.a.............++........ssssplL-ELVhLKsslIKHLCshEpLh.	0	0	0	0
+6708	PF06880	DUF1262		Protein of unknown function (DUF1262)	Vella Briffa B	anon	Pfam-B_6733 (release 10.0)	Family	This family represents a conserved region within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that some family members contain more than one copy of this region.	19.80	19.80	20.60	41.10	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.33	0.72	-3.69	9	75	2009-01-15 18:05:59	2003-08-11 13:15:06	6	3	13	0	52	73	0	99.20	45	26.52	CHANGED	EGPsSGlLVlp....DEcutsc..pCaGhCh..csplpGLPFPQNptLoVca.........psGpGcsphsa..tDsVVFlPVlsQPLSSNRYYsl+tsG+HuGcssAso.+EEDtVoCCFC	..............EGPNSGhLVIp....DE-upsp...s.....C..aGhsh..c.s.pl.c.sLPFPQNppLsVpa.............................ptstsppp.sh..h-sVlFIPVLsQPLSSNRYYslct.pGKH.pGpspssu..+E-Dhss..CCF.................	0	10	25	36
+6709	PF06881	Elongin_A		RNA polymerase II transcription factor SIII (Elongin) subunit A	Vella Briffa B	anon	Pfam-B_6598 (release 10.0)	Family	This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin [1].	25.30	25.30	25.30	25.50	23.90	25.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.16	0.72	-3.67	21	318	2009-01-15 18:05:59	2003-08-11 13:51:23	6	5	229	0	221	299	0	106.30	27	22.28	CHANGED	lp-lGslPaplLcPlLc+s.os-QLhclEcts..PtLhp-oD-LWpcahpRDF....................ccph.p-.-.......sWR-hYh+hp-cpcp+h....cpLppplppspsp+spt.+p.....hhlpsh	..................lt-lGs.lPaplLc.PlLp+s...os-QLhclEc..ps.....stLhp-...oD...cLWppahp+DF...........................................cp.p..t.spc.h-........................oW+-hYh+hpcpp-pcl........ptLppshpstptpK.pt.pt...h.....h.......................	0	66	111	176
+6710	PF06882	DUF1263		Protein of unknown function (DUF1263)	Vella Briffa B	anon	Pfam-B_6668 (release 10.0)	Family	This family represents a conserved region located towards the C-terminus of a number proteins of unknown function that seem to be specific to Oryza sativa.	21.60	21.60	24.30	23.80	21.10	18.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.36	0.72	-4.43	8	155	2009-09-10 17:20:14	2003-08-11 14:02:11	7	12	3	0	132	154	0	86.80	58	53.41	CHANGED	MG+..sp.cSAGSRCNV..tutLSADDhTGVRPVTDRSFLSTTRQFShLHVCPSSYNDFLAMVuMKPGhYLsGTDVPoPGssTPAPARDECLEALIlPTGhGEACsRPPlAT	.....................................................................................................o.hsDFLAMluMKPGM.LsGTDlPTPGVsTPAPARDEs.EALIIPTGRGEACsRPPVAT...........................	0	0	0	0
+6711	PF06883	RNA_pol_Rpa2_4		RNA polymerase I, Rpa2 specific domain 	Finn RD	anon	Pfam-B_4721 (release 10.0)	Domain	This domain is found between domain 3 (Pfam:PF04565) and domain 5  (Pfam:PF04565), but shows no homology to domain 4 of Rpb2.  The external  domains in multisubunit RNA polymerase (those most distant from the  active site) are known to demonstrate more sequence variability [1].	21.30	21.30	22.40	26.50	21.20	20.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.91	0.72	-4.01	31	319	2009-01-15 18:05:59	2003-08-11 14:20:06	7	28	270	0	214	329	3	58.50	41	5.23	CHANGED	lGalssctApplsssLRhhKlt..........s.ppplP..............pLEIuaVPso...ps..GpYP.GLYlFossuRMhR	...........lGass...c.tuttlucsLRhhK..Vp...................u..ppplP..............pLEIuaVP.o.....ps..GpYP.GLYLFossuRMhR............	0	77	123	181
+6712	PF06884	DUF1264		Protein of unknown function (DUF1264)	Vella Briffa B	anon	Pfam-B_6839 (release 10.0)	Family	This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 200 residues long. Some family members are annotated as putative lipoproteins.	25.00	25.00	34.70	27.90	18.80	19.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.12	0.71	-4.81	28	339	2009-01-15 18:05:59	2003-08-11 15:00:49	6	7	284	0	133	261	2	167.10	51	67.11	CHANGED	shsPlcplstHLsu..........FHhYucDPsR.plEApHYCs.+lsE.......DhtQCllYDussssA+LlGlEYlISt+LFpTLPs-E++LWHoHsaEV+SG.Llh............................Ps.....lPps....AE+stMcclhshYGKTaHhWQs....DRGDsLPLG.PpLM..huFop-uplc........tLlcpRDc+h.Glss...ct+RcpRt-.lpts	...........................p..sPlctIssaLsu..........FHhYusD......hst....QhEAHHYso.hLNE...............DlhQslIYDus.sps.ARL........hGVEYIISE+LFcT.LP.sEEKKLWHSHpYEV.......KSG.Lls.................................PG.........lPps........s-+shMpcllsTYGKTWHTWps.....DRsc.......sLPhGhPtLM..MuFT..sD..GQlcs.......sL.lt-RDcRh...GlDTpth..+cpRp-.ls.........................	0	41	76	110
+6714	PF06886	TPX2		Targeting protein for Xklp2 (TPX2)	Vella Briffa B	anon	Pfam-B_6863 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [1]. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.73	0.72	-3.90	20	364	2009-01-15 18:05:59	2003-08-11 16:21:19	6	9	95	0	225	353	0	56.10	38	11.62	CHANGED	h+o-cRAccRpEF.pKlcEKppthctppppsEtppcpEEEptl+QLRKpLV..aKApPh	........h+s-cRAccRp..E.....F.p+lcEKppthE..tp+pptctppc..............EppEp-.l+pLR.K.p.Ls..aKApPh......	0	58	137	180
+6715	PF06887	DUF1265		Protein of unknown function (DUF1265)	Vella Briffa B, Pollington JE	anon	Pfam-B_7101 (release 10.0)	Family	This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be restricted to C. elegans. The GO annotation for this protein indicate that its a protein involved in nematode larval development and has a positive regulation on growth rate.	25.00	25.00	59.40	58.40	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.35	0.72	-4.30	7	20	2009-09-11 00:32:59	2003-08-11 17:07:06	9	1	4	0	17	22	0	47.90	52	15.25	CHANGED	EELhpNhEDlhYVppLLllAcsu+hpslpssC.ATll.aHhpDFhR.h	.EELhKNaEDlhYVCNhLIlA-Du+FsslpsCClATllhYHFsDFhR....	0	10	13	17
+6716	PF06888	Put_Phosphatase		Putative Phosphatase	Vella Briffa B	anon	Pfam-B_7115 (release 10.0)	Family	This family contains a number of putative eukaryotic acid phosphatases. Some family members represent the products of the PSI14 phosphatase family in Lycopersicon esculentum (Tomato) [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.64	0.70	-5.20	9	337	2012-10-03 04:19:28	2003-08-11 17:25:44	7	8	166	0	194	898	85	208.20	31	78.97	CHANGED	hlllFDFD+TIIDtsSDshVVcthssppl.ppLpsoh....WNphMsRhhp.LpsQG.hs.t-l+psl+slPlsPthlchl+th..ps.th-LhIlSDANpFFI-phLcttulpshFsc.IhTNPushDu.pGpLpltPYHs.....Ho.Cs..hCPsNhCKGhVl-chhspt..pcGhthcRllYlGDGssDaCPsl+LppsDhshPR+GaPhachlsc....ssthl+ApVh.WssGt-lpchLhtll	........................................................................lllF.DF...DpTIl-..p.....s..........S..D.........s..h.........l......l.....p.......t..h.........s..t.....p.........p.....h...........p...p.....L...t....t...p.....h....p.....................W..s..p..h..M...........s....c.hhp.............L...........t.p..p.......u.....h....p............p.......c........l..t....p.....s.........l..................p.p.....lP....h...s..s..th....h.p.hl..ph.h..............t...t.........s.............h-..lh..llSDu.NshaI-phL....ctt.u...........l..p.p.....h..Fs..c..lhoNP.u.t.h.......s..t.....pG......p.....L....p....l....p......P...aHs.............................Hs..Cs.....hC....P....s..N...h...CK..t.......tl..l.p.....c.hhpp........................t..u.h................hp.+..llYlGDGssDh....CPshp.LtttD.hsh.sR......+..s......a....s..h..chltp...........p...hp..u.plh.Wpsu.-l.p.h...................................................................................................	3	60	104	151
+6717	PF06889	DUF1266		Protein of unknown function (DUF1266)	Moxon SJ	anon	Pfam-B_13878 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 235 residues in length. Members of this family seem to be found exclusively in the Enterobacteria Salmonella typhimurium and Escherichia coli. The function of this family is unknown.	21.80	21.80	22.20	21.90	20.70	21.60	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.90	0.71	-4.46	66	1230	2009-01-15 18:05:59	2003-08-12 09:14:11	6	6	645	0	86	576	3	174.40	29	66.70	CHANGED	pptLppsWGIsc+c....shhpplptlh..spGcp...............................................................hthhpphtp.htthttttspphththphhpth..................htttuhhAWDhuRhshlsRh...uhhsGalsccEshphhhpsuppspptasSWc-ahtuYhhGpthWtssssppphtttth...............pLhpssp.........uPat.................t.ls........Wp	.............................................................................................................h..sLpspWGIpsp-shhphl.phh......sssHu........................................................sphts.htphhcps.....p.hpchhsths.-p.sp.....thsp..alutp..............................suttsIhAWDhsRMuaLoRh...ushNsalsEE-uhal..psth+A..pchacoWccYhsuYhhGRhYW.....ps.sps.c..pphhht...chht.h................plhtssc....paat...........sLPWp..................................................................	1	32	58	75
+6718	PF06890	Phage_Mu_Gp45		Bacteriophage Mu Gp45 protein	Moxon SJ	anon	Pfam-B_10848 (release 10.0)	Family	This family consists of Bacteriophage Mu Gp45 related proteins from both phages and bacteria. The function of this family is unknown although it has been suggested that family members may be involved in baseplate assembly.	30.10	30.10	30.30	30.10	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.98	0.71	-4.79	8	376	2009-09-13 01:58:40	2003-08-12 09:25:51	7	2	328	0	52	300	4	162.70	32	86.85	CHANGED	uRAVVoulssspKpQslQl+lhAGEspDcVE+LpsYGaoSsP.sGAEAllshsGGcRSHuVsVVVsDRRaR.pGLpsG-VuLYccEGcplpLT+sGclI.sus.......Kolplp.......uuppspF-oP.sphTGslcsssD.u..............Gsshus.cpstshsh.GHtH+-susGus	...........................RuslshlssutphQsl.Qlp.h.husEstsslE+hp.YGF.oS.s.s...sGuEulllhlG....GcRS+uVllslpc.ccYRhpG.LpsGEsAlYs.c.pG.p..p.lpLp.+.tGhl.lcsss..............................cs...lplp...............AsspsphpsP...lps.oGp.lpspss.s...............................utshss....t.h....shs.........sHpHppsstt..s...........................................	0	12	26	42
+6719	PF06891	P2_Phage_GpR		P2 phage tail completion protein R (GpR)	Moxon SJ	anon	Pfam-B_10918 (release 10.0)	Family	This family consists of P2 phage tail completion protein R (GpR) like sequences. GpR is thought to be a tail completion protein which is essential for stable head joining [1].	25.00	25.00	27.00	26.80	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.44	0.71	-4.37	48	720	2009-01-15 18:05:59	2003-08-12 09:29:35	6	5	527	0	86	497	3	130.00	37	85.41	CHANGED	M..........hK.ppL+shLhssl..sphtsss-p....lcsal-sGplhsssp..u.uh.........chpYshslhlpcass...csshlhsslhsWLpspps-...p.c..tcppshpFcl-l.scsss......DlpIplp.LsEclhltcct......sGtlph....pttt.s	..........M...KspSLRpALscul...shhpsNP-p....LplFV-sGslhsTut..ohSa................-aRYslslhlpDasG...-.shLhsPlLsWLc-NQPDlh..ssp..h+ppshsFps-I..cs-ss......DlslsL..LTERVllsps.......pGs..thpth....................	0	8	34	60
+6720	PF06892	Phage_CP76		Phage regulatory protein CII (CP76)	Moxon SJ	anon	Pfam-B_13444 (release 10.0)	Family	This family consists of several phage regulatory protein CII (CP76) sequences which are thought to be DNA binding proteins which are involved in the establishment of lysogeny [1].	21.30	21.30	21.70	21.50	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.70	0.71	-4.92	15	350	2009-01-15 18:05:59	2003-08-12 09:37:11	6	2	313	0	50	250	8	153.50	44	91.22	CHANGED	-apsSKps....+FDpACpsFAspaNlscLAccsGhss.QhLRNKLNPpQPHpLTssELltITchT.sDpTllsuhLhplsslsss.Pssps...uc....sl.ppslcsoupsG-luptAlph.uscRlTpspKcpllppApuuIppLuLlhtslEsRhQ.AsPshuhssDslsu	.....................DaphSKHs....HFDpACRuFAlcH..N..h..s...pL..Ac+sG..Mss....QsLRNK..L..N..P.p.Q.P.H.p.L.TssElhhLTDlT..EDuTL......lDGhLAQIp..CLP.s.V....P...lNEs.....uc....tpLs.chVhsAT....A-lGclAus...AV...S..s-.hhTsutR...+shlsslNushRhhuLhAhslpuRlQ..usPshsuuVDslo.u.......................................................	0	7	19	38
+6722	PF06894	Phage_lambd_GpG		Bacteriophage lambda minor tail protein (GpG)	Moxon SJ	anon	Pfam-B_11957 (release 10.0)	Family	This family consists of Bacteriophage lambda minor tail protein G and related sequences. The role of GpG in tail assembly is not known [1].	19.20	19.20	20.40	20.20	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.77	0.71	-4.51	7	773	2009-01-15 18:05:59	2003-08-12 09:47:44	6	2	336	0	10	332	0	122.70	54	90.90	CHANGED	MFLKoEpFpasGsSVsLSELSALQRIEaLpalppcstph-sp......uccpssh.phslchsAaLVuhSLWcu.........s.sp-spplpppVhtsWsh-AluputphVLhLSGM......psssppsspss	...........MFLKTEpFEYNGVSVTLSELSALQRIEaLAhlppcAEQ.t...Eos.........uscpl...sl.....cc...hlcTuAaLVAMSLWHsHs.Ks.p.sShsEsVppIcQEVlTTWPs-Alup..ApssVLpLSGM..hshpsssssppstc..t..................................................................................................	0	0	1	4
+6724	PF06896	DUF1268		Protein of unknown function (DUF1268)	Moxon SJ	anon	Pfam-B_11819 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.	21.90	21.90	22.40	22.10	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.44	0.71	-3.74	4	65	2009-01-15 18:05:59	2003-08-12 09:56:36	6	1	61	0	12	57	1	118.20	23	90.05	CHANGED	Mc...IKlsclpc+oaEVKTS.+NlcKMacaQLshActp-pIusups.p.sclshsh.......LcshltFloslLsLsKcEh-KL.t-LEhpchhclsshlVthh.GhoD-pI-pu.sccsDs..uc	...............................................l.h....p..l....p+shpVpsospslc+hpch....Qlthhctp...s.plp..csp.t.h....phhch...phph.............lcchhcFlpplLsLsccph-Kl.-c.l.-hpchtchsshlsh+lp..GhsDcplchs.tpp.....p................	0	3	6	10
+6725	PF06897	DUF1269		Protein of unknown function (DUF1269)	Moxon SJ	anon	Pfam-B_14034 (release 10.0)	Family	This family consists of several bacterial and archaeal proteins of around 200 residues in length. The function of this family is unknown. The family carries a repeated glycine-zipper sequence- motif, GxxxGxxxG, where the x following the G is frequently found to be an alanine. As glycine-zippers occur in membrane proteins, this family is likely to be found spanning a membrane.	22.40	22.40	22.40	22.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.01	0.72	-3.99	40	415	2012-10-03 03:18:43	2003-08-12 10:27:11	7	3	359	0	124	303	40	101.70	31	38.74	CHANGED	AluGuhWGhLlGllFhsPLlGh....AlGAuuGAluGu.Lo..DhGIsDsFl+-lucsLpPGooALFlLl+csssDKVlpclptas..GcllpTSLSc-cEppLpcALspu	.......................................htGuhhGhLlG.llh..hs..slhGh.......................AlGAusGAluGs...hs...D...hG...Ic...D...s...h...h...cclupsLss.Gouulhlls.cc.ts.-cVhs.s.lp.shs..upllppsls..tt..l.t.....t..............................	0	53	82	106
+6726	PF06898	YqfD		Putative stage IV sporulation protein YqfD	Moxon SJ	anon	Pfam-B_13823 (release 10.0)	Family	This family consists of several putative bacterial stage IV sporulation (SpoIV) proteins. YqfD of Bacillus subtilis (Swiss:P54469) is known to be essential for efficient sporulation although its exact function is unknown [1].	25.00	25.00	26.40	29.80	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.05	0.70	-5.76	8	428	2012-10-01 23:48:22	2003-08-12 12:30:40	6	2	409	0	89	349	7	353.90	27	95.03	CHANGED	KhpappFh+GhVplclpGhsIE+FLNhshppsI.lhsl++hsspslshplsLpDhKKl+plsK+spCKlphlcR+GhPFllhRh+++hulllGhllFllllahLSshlWcIDIpsscshsEa-lRppLs-hGVKpGshpFsl-.lpKlp+cLhpshssIhWlGVclcGTol+lcVVEKppP...-.tpps-PpNlVAKKcGhIpRlaVpcGpslVKlsDhVKKGDlLVSG.lGpEspcpt............VsAcG-VhAcTWYEsplcV.LpsphpshTGcshssaalphtuhplsl...shpcpEFccacp.pcp+sh.hh.aphPhphs+pphYEspppptchsK-EAVccutKhuccclpcplucsuclhscKVh+cclEsGKl+LplhhpV.EsIu	...............................................hh.Ghlplclp.G.hshE+FlN.shpptlhlas.l........p+hs.ps.hhhph.lp-h+cl+slh++sps+lpllp+hG.hPFhht+hh+.ppsh.hlGhllFhhhlhhhSshlWpI...-I..p...Gs..p....s..ophtlhptL...c.c.h.Gl+.Ghhphpls.spclpcplpp.ph.s.s.lsWlulclcGTphplcls...E...+p.pP.................phtp.pppP...........p...........slVApKculIpchhsppGpslVphsDhVcKGplLlS..G.h.h......s..p..c..tp...t........................V..p....AcGpVhuc..T..aYpt.ps..plslppp...hp...hh.TGpphpp.hhlphsstpl..hl.........s..h..tp....ppac.ph.c.p.p...pp.ph.p.h.h.t.h.h...l.P...lthtpphhhEhcphptph...o....c...cpAhphutchspc.plppp.l....s.pp.s.pIls.......c.......p...l.h......p..h...c..s..splchplhhps.EsI...............................................	0	47	74	79
+6727	PF06899	WzyE		WzyE protein	Moxon SJ	anon	Pfam-B_13849 (release 10.0)	Family	This family consists of several WzyE proteins which appear to be specific to Enterobacteria. Members of this family are described as putative ECA polymerases this has been found to be incorrect [1]. The function of this family is unknown.	25.00	25.00	29.40	28.60	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.74	0.70	-5.79	3	583	2009-09-11 10:39:43	2003-08-12 12:41:03	6	2	559	0	43	231	0	431.40	85	99.60	CHANGED	MTLuQFGGLFVVYLLullFIATLTYpEFRRVRFNFNVFFSLLYLLTFYFGFPLTClLVFRFGVuVVPVEhLLpALLSATuFYGIYYVTYKTRLRpRsus.PRsPlFTMNRVETNLTWVLLALIALuTVGIFFMQNGFLLFRLcSYSQIFSSDVSGVALKRFFYFFIPAMLVVYFL+QDpRAWlFFLlSTVAFGILTYlIVGGTRANIIIAFALFLFIGIlRGWITLWMLAAAGVlGIVGMFWLALKRYGLNVSGDEAFYTFLYLTRDTFSPWENLALLLQNYD+IDFQGLAPIVRDFYVFIPSWLWP-RPSLVLNTANYFTWEVLsNHSGLAISPTLIGSLVVMGGVLFIPLGAIVVGLIIKWFDWLYEpGKAEoNRYKAAILQSFCFGAVFNMIVLAREGLDSFVSRVVFFCVIFGACLllAKLLYWLF-oAGLI++...RTsuLshsNAts	............MSLhQFSGLhVVWLLsTLFIATLTWFEFRRVRFNFNVFFSL.LFLLTFFFGFPLTSV...LVFRFDVGVAPPEILLQALLSAuCFYA.VYYVTYKTRL...R..............KR.V........u.......D...VP.....R..RPL.F..TMNRVETNLTWVILMGIALVSVGIFFM.HN.GFLLFRLsSYSQIFSSE.VSGVALKRFFYFFIPAMLVVYFLRQ...DSKA.WLFFLVSTVAFGLLTYMIVGGTRANIIIAFAIFLFIGIIRGWISLWMLAAAGVLGIVGMFWLALKRYGh...NVSGDEAFYT.....FLYLTRDTFSPW....ENLALLLQNY..DN..IDFQGLAPIVRDFYVFIPSWLWPGRPShVLNSANYFTWEVLNNHSGLA.............I..SPTLIGSLVVMGGALFIPLGAIVVGLIIKWFDWLYELGNREsNRYKAAILHSFCFGAIFNMIVLAREGLDS..FVSRVV.FFlVVFGACLhlAKLLYWLF-SAGLIHK...RTpS..psQVEG...............	0	1	11	27
+6728	PF06900	DUF1270		Protein of unknown function (DUF1270)	Moxon SJ	anon	Pfam-B_13907 (release 10.0)	Family	This family consists of several hypothetical Staphylococcus aureus and phage proteins of 53 residues in length. The function of this family is unknown.	20.60	20.60	20.60	23.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.89	0.72	-3.82	2	250	2009-01-15 18:05:59	2003-08-12 12:43:48	6	1	175	0	2	69	0	52.40	89	98.91	CHANGED	MSNIYKSYLVAVLCFTVLAIVLMPFLYFTTAWSlAGFASIAhhIFaKEYFYtc	.MSshYKSYLlAVLCFTVLAIVL.M.PF.LYFTTAWSIAGFASIATFIFYKEYFYEE...	1	2	2	2
+6729	PF06901	FrpC		RTX iron-regulated protein FrpC	Moxon SJ	anon	Pfam-B_14005 (release 10.0)	Family	This family consists of several RTX iron-regulated FrpC proteins which appear to be found exclusively in Neisseria meningitidis. FrpC has been shown to be related to the RTX family of bacterial cytotoxins. FrpC is found in the meningococcal outer membrane. The function of this family is unknown although it is thought to be a virulence factor [1].	25.00	25.00	162.40	162.10	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.83	0.70	-4.88	2	63	2009-01-15 18:05:59	2003-08-12 12:52:41	7	1	29	0	4	51	0	244.80	90	99.31	CHANGED	MRPYATTIYQLFILFIGSVFTMTSCEPVN..............EQTSFNNPEPMTGFEHTVTFDFQGTKMVIPYGYLARYTQDNATKWLSDTPGQDAYSINLIEISVYYKKTDQGWVLEPYNQQNKAHFIQFLRDGLDSVDDIVIRKDACSLSTTMGERLLTYGVKKMPSAYPEYEAYEDKRHIPENPYFHEFYYIKKGENPAIITHhNNRlNQsEEDsYSTSVGSCINGFTVQYYPFIREKQQLTQQELVGYHQQVEQLVQSFVNNSsKK	....................................MTSCEPVN..............EQTSFNNPEPMTGFEHTVTFDFQGTKMVIPYGYLARYTQDNATKWLSDTPGQDAYSINLIEISVYYKKTDQGWVLEPYNQQNKAHFIQFLRDGLDSVDDIVIRKDA.CSLSTT.MGERLLTYGVKKMPSAYPEYEAYEDKRHIPENPYFHEFYYIKKGENPAIITHRN..+....phtEssYSTSVGSCINGFTVcYYPFIRE......K......QQLTQQELVGYHQQVEQLVQSFVNNsSKK....	0	4	4	4
+6730	PF06902	Fer4_19	DUF1271;	Divergent 4Fe-4S mono-cluster	Moxon SJ	anon	Pfam-B_13906 (release 10.0)	Domain	Members of this family contain three highly conserved cysteine residues. This family includes proteins containing divergent domains which are most likely to bind to iron-sulfur clusters.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.32	0.72	-4.15	22	670	2012-10-03 08:56:42	2003-08-12 13:05:51	6	12	636	0	116	1472	82	63.60	50	63.97	CHANGED	YpGtplslhhstslCtHuupCl+...stPpVFc.tc+.PWl.....pP-suss....cplhphlspCPSGALsahcc	...........YoG-cIDVaaN.ssIC.p.HSGNCVR...Gss.c..lFsl....c...R...K....P....W...I.................hP..D...p.s.sl..............s.s...l.l.cV..I.-.o.CPSGAL+YpcK............................................	1	45	79	101
+6731	PF06903	VirK		VirK protein	Moxon SJ	anon	Pfam-B_13955 (release 10.0)	Family	This family consists of several bacterial VirK proteins of around 145 residues in length. The function of this family is unknown [1].	20.50	20.50	30.20	39.70	19.70	16.40	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.11	0.72	-4.26	14	134	2009-01-15 18:05:59	2003-08-12 13:13:00	7	1	124	0	27	101	2	97.70	37	70.18	CHANGED	spsLsshsplhp.ALssGKsVslslDLspCpsp...sssssssps+GGhpIcuahIssDsoluFuDpHFTlssc...G+PlhpFlRYplps-Gssphssh....shshPsap	.........s.sLsshsslhpALssGcsVslslDLupCpsc....tss.ssps+GGhplcuahIpsDsoluFSDsHFTlssc...scPIppFhRYplpssGsspFsshhhshssh...........	1	6	10	17
+6732	PF06904	Extensin-like_C		Extensin-like protein C-terminus	Vella Briffa B	anon	Pfam-B_6925 (release 10.0)	Family	This family represents the C-terminus (approx. 120 residues) of a number of bacterial extensin-like proteins. Extensins are cell wall glycoproteins normally associated with plants, where they strengthen the cell wall in response to mechanical stress [1]. Note that many family members of this family are hypothetical.	23.50	23.50	23.60	24.90	22.80	23.40	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.40	0.71	-4.50	81	626	2009-01-15 18:05:59	2003-08-12 13:17:00	7	3	464	0	171	507	50	171.40	35	62.79	CHANGED	sshChssLsttG....sph..sslssts....tsuCultssV+lpt.....suslslsssshh..sCshAtuhstWhcpslpPAApphhGp..slsplcphuoYuCRshsst...........u..u+lSEHApusAlDluuFpLsDGpcIoVhcsWp..s......spctpaL+pl+cuAC.thFsTVLGPch.sshHpDHFHhDh......uGht....hCR	............................................s..Ch.th.Lp...tts....h.h..pp.....h.sshp...ssupCslspslclps.......husltls.s..u.h.hh..sCshAhshAhalcpslpPsApphh.tp..plspIcphGoYuCRsh.pp.............s...u+hSEHApu..............sAlDluuFpLuD..G......+c.IsVh.cs.W.t...p...............tcpt...s....aL+...slps.......uuC.....phFssVLG.Psh....Nu.sHt...sHFHlDh...........suhthC+..................	0	33	86	125
+6733	PF06905	FAIM1	FAIM; 	Fas apoptotic inhibitory molecule (FAIM1)	Moxon SJ	anon	Pfam-B_13985 (release 10.0)	Family	This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology [1].	20.70	20.70	21.30	20.80	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.25	0.71	-5.10	7	135	2009-09-11 08:59:28	2003-08-12 13:19:24	8	6	84	3	95	143	0	165.10	43	80.59	CHANGED	Mo...................DlVAhWDVsLuDGlH+IpFEHGTTSGKRVlaVsG+EllR+-WMFKLVGcETF.lGstpsKATIpI-AlSG..FuYEYoL-IsGKSLcKahEsRsKso+sWlhplDG.....t-hRlVL-KDTM-Va.....sNGpph-TtGEFs-sGo-T+FohusapChIpuhSSGpKRpGIlHpLllDGhc......lsps	..........................-lVAhWsVsLs.DslH+IEFEHGTToGKRllhVDG+.EhlR..+....-.WMF.KL.V...GcETF..plG...ps........+ssI...pIDAl.....uG.....Fs.YEYoLclsGKSLc+.......ahEspoK.phpoW.l.hpl.s.G................p.chRlVL-K..-T.h-l...W.........................sNGpph.Eo.su...EFV-sGT-.T+Fplu..sp.s.shIpAh.SSGp++pGIlHsLhlssptls.h....................................	0	22	27	74
+6734	PF06906	DUF1272		Protein of unknown function (DUF1272)	Moxon SJ	anon	Pfam-B_14128 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 80 residues in length. This family contains a number of conserved cysteine residues and its function is unknown.	23.10	23.10	23.20	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.32	0.72	-4.12	35	286	2009-01-15 18:05:59	2003-08-12 13:22:27	6	1	282	0	95	231	22	55.90	62	72.70	CHANGED	M.LELRPNCEsCD+DLPP-u.-AhICoFECTFCssCs-shh.pslCPNCGGpLltRPhR	...M.LELRPNCEpCDpcLPsDS.-AhICo.aECTFCAsCs-ph..pshCPNCGGELVcRPhR..	0	14	45	64
+6735	PF06907	Latexin		Latexin	Moxon SJ	anon	Pfam-B_14203 (release 10.0)	Family	This family consists of several animal specific latexin proteins. Latexin is a carboxypeptidase A inhibitor and is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat [1].	25.00	25.00	26.10	26.10	18.90	18.10	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.50	0.70	-5.18	4	94	2009-01-15 18:05:59	2003-08-12 13:28:15	7	2	41	3	42	84	0	188.10	41	88.21	CHANGED	slsss+thhphAApsALHahNa+pGSPStLhlLtpVQcupuhh.PpcGpKhalhFSTEpY.......cGE.phGpCoAcVha..hsppPtPsVNsTCs+hhsKpphQEEDaphYcphppLKpPLcu.sIPDsaGpIsssh+.lWcLAalGSSYVMWcpoTpsoaYhLsQloSV+QhppsDDsI-FDaTVLLHEluTQEIIPC+haLVWaPG+PlKVKYpC..-ppu.EE	......................................hsssph.htpAAtss.phhNhptGoPptlhhlttVppup.hp........PtpGpKaplpFosEch..........p.tp.hhspCoAcVha....tspcs..tP.t.lphThpt.ht.Kp..pc-D.thYpph+p.h+pPLpu.sIP.D..saGplsPphpPlhcLAhlusuY..lhWppoTEpphYhhsplpoV+Qh.pps.D.DhI-hDYslLLH-h.soQ.EIIPhphpllWhPthshK.VKaps...hps..............	0	2	5	17
+6736	PF06908	DUF1273		Protein of unknown function (DUF1273)	Moxon SJ	anon	Pfam-B_14270 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	21.60	21.60	22.10	22.60	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.02	0.71	-4.61	41	1168	2012-10-01 21:16:48	2003-08-12 13:44:34	6	5	1090	1	113	625	5	170.30	37	95.22	CHANGED	M...pplhVTGY+uaELGI.Fp-cDPclplIKpAlc+pLhphlE..-.G.l-WlIhuGpLGhEhWusEVsh-L+p-.YPpl+lAllhPFpspuppWsEsNQt+hpslhppsDFscslsc.psYp.........sPtQh+phspFhlc+TDuslllYDpEpcGpsKYhhchhcchpppp.sYslphlsh--Lp-hs...p-	.....................................M.pslhVTGY+uFE.Lu.l.Fp-.c.cP.clp.hIKpsl++cL...pphl.-..-..G..l-.WllhsG.pLG.hEhWssEVshEL..+..p-..Y.s....lpl..AslhPF..psau.ppWNE.s...NQt+hsphhppsDaVc.lhp.p.Yp............sPtQh+phspFhL-....po-sslLhYD......cE..p.c......up..s.cY.hhpthppht......sY.hchloF-cLpphhp.t..................................................................	0	35	66	91
+6738	PF06910	MEA1		Male enhanced antigen 1 (MEA1)	Moxon SJ	anon	Pfam-B_14358 (release 10.0)	Family	This family consists of several mammalian male enhanced antigen 1 (MEA1) proteins. The Mea-1 gene is found to be localised in primary and secondary spermatocytes and spermatids, but the protein products are detected only in spermatids. Intensive transcription of Mea-1 gene and specific localisation of the gene product suggest that Mea-1 may play a important role in the late stage of spermatogenesis [1]. 	19.00	19.00	19.40	19.40	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-4.60	2	97	2009-01-15 18:05:59	2003-08-12 13:52:09	6	2	84	0	51	84	1	122.60	50	88.78	CHANGED	MAsVVLGGDTMGPERIFPNQTE-LG.HQGPoEGTGDWSSEEPEEEQEETGuGPAGYSYQPLNQDPEQEEVELAPVG-G.DssADIQDRIQALGLHLPDPPLESEDEDEEGAsALssHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWApEISDAQWEDVVQKALQARQASPAWK	.....................................................................................................................................................................................Y.PLs.............t.t.............................t.......t............t.t.....hth..h.h....sp...ss...ps..tDE.-E....E...GAsAhs...s..+S..SIPMDPE.HV..E.l+psMAslsLPs.ulPsWAptls-tpW.cc..l.ptlptpp.....................	1	10	15	30
+6739	PF06911	Senescence		Senescence-associated protein	Vella Briffa B	anon	Pfam-B_7525 (release 10.0)	Family	This family contains a number of plant senescence-associated proteins of approximately 450 residues in length. In Hemerocallis, petals have a genetically based program that leads to senescence and cell death approximately 24 hours after the flower opens, and it is believed that senescence proteins produced around that time have a role in this program [1]. This family extends to the higher vertebrates where the full-length protein is often a Spartin, associated with mitochondrial membranes and transportation along microtubules [2].	21.60	21.60	21.80	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.68	0.71	-4.58	59	334	2009-01-15 18:05:59	2003-08-12 13:54:44	7	9	197	0	227	312	3	172.70	26	36.16	CHANGED	slspG......uspls+GlhtsushsuptlppGuphhpp+.............h...ps.....spp.......s..............h.....plsPps...............ppplc....cl+phopsstplo....pthlssVspsustlusslspphst..............................tthtshhs..lhhuolpuhuplh....DulEpuu+slhpssussosphVpH+YGppAGpls..pcshsssusssh..sshsstpltp+Alh	.............................IhsGuuhlupGllpsu-.hsuptlppGush.hpp+............................h.......pP.......ppc.......P...................................sphsPss...............pcplc.................ts+phottusplo....pt.h..lssVsps.usshutplusphtt.............................................................t.....tp..t.hpsths....lhsuSlpu...Fuslh....sulEpAu+plhsssossssphVpH+YGppAupso..ppshsustsssh...sshsl.tlth+Al......................................	0	86	137	184
+6740	PF06912	DUF1275		Protein of unknown function (DUF1275)	Moxon SJ	anon	Pfam-B_13896 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although a few members are thought to be membrane proteins.	25.40	25.40	25.50	25.50	25.20	25.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.30	0.70	-5.13	176	2258	2009-01-15 18:05:59	2003-08-12 13:56:48	6	14	1641	0	642	1872	52	202.00	21	85.04	CHANGED	htluhhLu.hsuGhlDAhualsh.tthFsut.hTGNhshluhslu..tssht.shth....lhslhuFlhGshhushl............httttthtpththsLhlpsslLhhsuh...lshthss.........................hhshhhluhshGhQsushp..plssssl.sTThhTGsls....shuhsls...phlhtp...st....................hpphhhhhshlsuFhhGullGuhhhphhu.h..hulhhssslhhhlsh.hh..h	...............................h..hshhLs.hsuGh.....lD.Ahsa....lsh.......t.............hasut..T..G..........Nlshluhsls....pssh.t...t....shth.........................lhslhsFhhGshhsshl............................hpphp..h..tph.hhhslhhp..sll.lhh.suh...lstths.............................................hhslhhluashGlQssshp...pl.ss.h.......s.h.sosh.hTGslpphs..hsls..........phhhsp.......pp.......................hpc.hhhhhsllhuFhlGu.lhG.u.hh...h..t..h.hs..h...ts.lhhsshhhhhhhh...h......................	0	157	349	499
+6744	PF06916	DUF1279		Protein of unknown function (DUF1279)	Vella Briffa B	anon	Pfam-B_7316 (release 10.0)	Family	This family represents the C-terminus (approx. 120 residues) of a number of eukaryotic proteins of unknown function.	21.80	21.80	22.20	22.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.12	0.72	-3.68	31	454	2009-01-15 18:05:59	2003-08-12 15:35:11	8	12	287	0	318	442	4	100.30	29	39.87	CHANGED	p+hKplh+cYGhlulusalslShhshuhhYlhVpu....GlD.lsshlpplshs............................................................pshsp.h.ts..shuphslAYul+Khh.tPlRlslTluhTPh	................................................phKphh+cYGhsslslalslShlshshhY......hhlps.....Gl.-...lsshhphlshs......................................................................pshsp.t...h.tsu...thuphslAYulaKhh.hPlRhslTluhTP....................................................................................	0	108	170	257
+6745	PF06917	Pectate_lyase_2		Periplasmic pectate lyase	Moxon SJ	anon	Pfam-B_14500 (release 10.0)	Family	This family consists of several Enterobacterial periplasmic pectate lyase proteins (EC:4.2.2.2). A major virulence determinant of the plant-pathogenic enterobacterium Erwinia chrysanthemi is the production of pectate lyase enzymes that degrade plant cell walls [1].	21.30	21.30	21.50	36.40	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	557	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.86	0.70	-6.26	5	122	2009-01-15 18:05:59	2003-08-12 15:38:44	7	1	69	3	19	88	5	490.50	53	98.49	CHANGED	AolhusuupAQDs-RLouVKpYlDNVLsKAuDpY..t+PTPLLADGVDPRTGKQlEWIFPDGRsAVLSNFSAQQNLMRVLlGLSsLTG-s+Y+pRAEcIVRYaFs+YQD-o.GLLYWGGHRFVDLKTLQPEGPSEKEMVHELKNAYPYYDLMFuVDs-ATARFI+GFWNAHVYDW+sLETSRHG-YGK...........sMGuLWQScFEQQPPFFATKGLSFLNAGNDLIYSAS...LLY+aspDsGALsWuKRLAcQYVLPRDsKTGLGVYQFTQPLKR-.EPsDDuDTHSKYGDRAQRQFGPEFGssALEGNMLLKGRTSTLYSENALMQLpLuKcLGssGs-LLcWTlDGLKAFA+YAYNsssNTFRPMlANGpDLSsYsLsRDGYYGKKGTVLKPY.PAsNEFLLSYARAYsLssDs-LW+VARGIApsQGLG-lGsssGu-lKlNMpTsNs-PYALFALlDLYQAoQss-YLcLA-+lGDNllcpRalcGFFlAssc+pYAcVDsIEPYALLALEAAlRNKPsuVAPFLNGAGFTEGuYRhsDGosRVSTRDNELFhLpsGEhLpPNsKK	....................h..........h.hshLosl+pYVD.V.shupsph...pPoPLLADGhDshTtQ.h.W.FPD..G.+csslSNFuuQQNhhRshsuLS.lotDPpYpppAc..spYahQp.h..cpS.GLhYWGGHRFlsLcTLpsEGPupK-pVHELKpthPYYDLhholDp-tThpFlpGFWpAHV.DWchL-huRHGpYuK.......................hssl......uph.p.P...tTKGLoFlNAGsDLIYuA....hhhcYptD..................tuAhsWuK+LhcQYVLsRsscTGLsVYQFops.pRp..PsDDsp...TpShaGDRApRQFGPEF..G.hAhEuNhhh+.chps......Lh.-NsLh.Lplh+p..t.ss-lLpWslDGLKsah+aAYs.psNThRPhhssGQDhSsYsLsRDGYYGtKGoVlpPa..hss-aLlshsRAat....l.spD..Lhclhtslh..c.tLu-ls.........ps.t+t......hph.phppssusPYhLhALl-LhptsQssphhoLA.plGDslh+p+Yh.cGhFhtSsp+pYhclDs..PhALLsL.AAhpNK.tAls.FlssuGahcGsY+hs.GpuRh.hc.s.la........................	0	1	8	12
+6746	PF06918	DUF1280		Protein of unknown function (DUF1280)	Vella Briffa B	anon	Pfam-B_7457 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long within a number of proteins of unknown function that seem to be specific to C. elegans.	25.00	25.00	25.40	27.30	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.25	0.70	-5.15	7	110	2009-01-15 18:05:59	2003-08-12 15:40:44	9	4	9	0	110	87	0	176.60	23	29.56	CHANGED	phhs+pshpp.Rh-phLcthpp...sss-hspFlpphl+hlsppsp.sa+..hoscEThhhht+hcLScsph+phKphh+phlGh-lLsShcplppL+ppLus.spYKlop.hssp....G+hlphhplh....cl.csltcRlEpLstpspLl.Ds..tscIhlslhuDpGutpTKlClsItNsppPNSshpllhluhasssDststlpcahsslh..Lschppl	..............................................................................................................h.......h...ph..hht.htp................t....p.p.hh.thh.phhtpp........php..ho..pshh.......hh.phphopt.hp.hKphhpp....hhh-.h.....sshpphtphpp.hss.p....aphp..........spth.h.....th.h.....slpphltpRLppLttpspLh..hcp....tspIhlsluGDKGuspsKlsl.ltNlppPNsspsllhluhapusDshpslpp.htslhpphNpl............................	0	27	56	110
+6747	PF06919	Phage_T4_Gp30_7		Phage Gp30.7 protein	Moxon SJ	anon	Pfam-B_14625 (release 10.0)	Family	This family consists of several phage Gp30.7 proteins of 121 residues in length. Family members seem to be exclusively from the T4-like viruses. The function of this family is unknown.	29.60	29.60	30.20	69.90	22.80	29.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.67	0.71	-4.12	2	33	2009-01-15 18:05:59	2003-08-12 15:45:57	6	1	32	0	0	18	0	121.30	86	99.55	CHANGED	MNYINFERKYVSNGIAGS.-sICLWKHpNGoVCEIEQhMTPNYVYMRFENGITVSITMcGSNFKIALDDDFRQRDLGTHPCWNGsNRKLLVKTWIRHILSNRAKPEHLEAIFDVVLNEFDI	....MNYINFERKYVSN...GIAGSIDTICLWKHQNGSVCEIEQYM..TPNYVYMRFENGITVSITMEGSNFKIALDDDFRQRDLGTHPCWNGsNRKLLVKTWIRHILSNRAKPEHLEAIFDVVLNEFDI..	0	0	0	0
+6748	PF06920	Ded_cyto		Dedicator of cytokinesis	Vella Briffa B	anon	Pfam-B_7154 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.	20.60	20.60	20.60	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.90	0.71	-4.97	25	1240	2009-01-15 18:05:59	2003-08-12 15:48:52	8	27	253	8	667	1086	2	172.80	32	10.33	CHANGED	T.F-+spslp+Fha-sP..Fohs..G+.sp..G....slccQa+R+TILossssFPhl++RlpV..hpcppl-l............oPIEVAI-plppKstELstthspp...........shphLQhhLQGslsssVNtGPhchAcsFLsp..h....sth.tcphp+L+pshc.........cFhptsppALclpcpLhttc.tp..hpccL-psa.pphpppLps	...........................................F.+s.plp+FhappP........Fp.hs.........s+...tc..........s..................phpc.ahc+TlLT..Ts.p..s...........FPhlh+....RhpV......hp.p..p.p.h.pl....................................oPlEsAI-phppKsp...-...L...pp.h..h....pptt...................................sshp......LphhLpGsV......ss.s...V.N....u.......G.......s....hpY...........tc..s.....Fhscp.h.....................c..stc..+lp...pL+phhp.......................p.h...t..hhtpuLpl.pcc.h.l.t.t.-...pt........hpccLpppa.pphtpplp.t........................................................................................	0	199	276	456
+6750	PF06922	CTV_P13		Citrus tristeza virus P13 protein	Moxon SJ	anon	Pfam-B_14711 (release 10.0)	Family	This family consists of several Citrus tristeza virus (CTV) P13 13-kDa proteins. Citrus tristeza virus (CTV), a member of the closterovirus group, is one of the more complex single-stranded RNA viruses [1]. The function of this family is unknown.	25.00	25.00	184.90	184.70	20.00	18.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.56	0.71	-4.24	3	58	2009-09-11 02:40:01	2003-08-12 16:01:31	6	1	1	0	0	53	0	114.90	92	100.00	CHANGED	MSIRRVWLKVMAVITVLWYGKEPSISEGYNALMNDDFKFIDTHFSNVSYAKKCYDLANFDLDFLRIVIIPLSGGTVNESRADRTNVSEIVESHVSDRDRM+ILLRNKRIQIPSLLPCDN	MSIRRVWLKVhAVITVLWYGKEPSISEGYNALMNDDFKFIDTHFSNVSYAKKCY-LANFDLDFLRIVIIPLSGGTVNESRADRsNVSEIVESHlSDRDRMsILLRNKRIQIPSLLPC....	0	0	0	0
+6751	PF06923	GutM		Glucitol operon activator protein (GutM)	Moxon SJ	anon	Pfam-B_14714 (release 10.0)	Family	This family consists of several glucitol operon activator (GutM) proteins. Expression of the glucitol (gut) operon in Escherichia coli is regulated by an unusual, complex system which consists of an activator (encoded by the gutM gene) and a repressor (encoded by the gutR gene) in addition to the cAMP-CRP complex (CRP, cAMP receptor protein). Synthesis of the mRNA, which initiates at the promoter specific to the gutR gene, occurs within the gutM gene. Expressional control of the gut operon appears to occur as a consequence of the antagonistic action of the products of the autogenously regulated gutM and gutR genes [1].	25.00	25.00	30.20	29.90	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.12	0.72	-4.41	26	859	2009-01-15 18:05:59	2003-08-12 16:06:25	6	1	822	0	71	301	39	109.20	43	81.79	CHANGED	hhhL..IlhhshAallQhlLGahQl+pFN+sapplp.....ppG..+VulG+ppG+h+sGsllllulD.cpspllcuphMpGlTVFARh+slsthpGhsltplp...shlhtps+hsppAl	.........................l..sLlslAlIAas..sQluLGhaQIp+FN+sacpLp.....QpG..+VulG..Rs.uG...RF..K.s.pslVhlAlD.-ppRls-shhM+GlTVFAR.pclsshsGhclt-lp....scllhscD.LsQpAl...........................	0	23	39	56
+6752	PF06924	DUF1281		Protein of unknown function (DUF1281)	Moxon SJ	anon	Pfam-B_14730 (release 10.0)	Family	This family consists of several hypothetical enterobacterial proteins of around 170 residues in length. Members of this family are found in Escherichia coli, Salmonella typhimurium and Shigella species. The function of this family is unknown.	25.00	25.00	35.20	35.10	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.61	0.71	-4.76	4	277	2009-01-15 18:05:59	2003-08-12 16:09:33	6	1	198	1	17	220	2	126.30	69	46.55	CHANGED	LhITGpss.lDtlppWssGchlPhYR+AlpQSI+LFLAGCAGlLpP..TcshcYs.aPsLlutGsGtsSspNlAFp+WLsLLppsVsLDtpssp.I-RLYhQSGluphKWEslPssA+cphsslhspphuDWFGls	...........MaFSGEPAQIAEIKRLASG.AVTPhYRRATNEGIQLFLAGSAGLLQs..TEslcaEPCPGLTAA.G......R...G.sVSPENI.AFTRWLTHLQsGVLLDEQNCLMLHE...LWLQSGTGpRRWEsLPDDsR-oITshFTsKRGDWCshW.....................	0	0	4	13
+6753	PF06925	MGDG_synth		Monogalactosyldiacylglycerol (MGDG) synthase	Vella Briffa B	anon	Pfam-B_8075 (release 10.0)	Family	This family represents a conserved region of approximately 180 residues within plant and bacterial monogalactosyldiacylglycerol (MGDG) synthase (EC:2.4.1.46). In Arabidopsis, there are two types of MGDG synthase which differ in their N-terminal portion: type A and type B [1].	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.30	0.71	-4.35	12	972	2012-10-03 16:42:30	2003-08-12 16:37:42	6	10	725	0	253	763	37	160.40	26	40.98	CHANGED	HppuAculp........pthptt.h.pphplhhhDshp.hssh.hphhhps.Yhhhl+h.....u...slathhahhsp.ch.....pshhsthtthhsp.cltshlpchpPDllIsTHPh.tth.l.hL.+p+phh.pshhs.sllTDats.H.hWh+.tlDthalssp-htcchlp.pGlspsplhshGIPl	......................................................................................HhpsApulh........pthpp...........sp.....hplhhhDh..ht.t.t.p.P.h..h..ss.lhpph..Y.hp..h.ch...................h.....ph.at.h.hah..h.s..p.......c.hh........ppph.h.......h....h....p...h....hhh..p....+...lh.p...ll.........p.c......tcPD..l..Il....sTaP.h.........h.l.t...l...+.......p.......c...th....h........s.......l.P.ls...sVlT.D....a.......h.H..phW..lp.st..s.-.tYa.Vuoc.......cs.+p.phlp..hG.lssspltsoGIPl........................................................	0	109	193	226
+6754	PF06926	Rep_Org_C		Putative replisome organiser protein C-terminus	Vella Briffa B	anon	Pfam-B_6517 (release 10.0)	Family	This family represents the C-terminus (approximately 100 residues) of a putative replisome organiser protein in Lactococcus bacteriophages [1].	21.40	21.40	22.30	47.80	20.30	20.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.12	0.72	-3.89	3	25	2009-01-15 18:05:59	2003-08-12 16:56:25	6	3	20	0	5	17	0	91.90	62	35.97	CHANGED	NSLLS+FLDoFINFSSKNISKRAMApsEFlKLPSFQK-QAVIGAcNYIQsYKNEHPDDcTG+YSVNuYsFL-NsMFMsYQEKVKADTGYDEDLGF	..NSLLS-YLDoFIpFSSKNIuK.RAMApsEFhKLsSEpKcQAVIGAcNYhpWYKpEsP-DcTtKFSlNuYsFL..-sshFcsaQpKVKsc...cEsLGh...........	0	3	3	3
+6757	PF06929	Rotavirus_VP3		Rotavirus VP3 protein	Moxon SJ	anon	Pfam-B_14798 (release 10.0)	Family	This family consists of several Rotavirus specific VP3 proteins. VP3 is known to be a viral guanylyltransferase and is thought to posses methyltransferase activity and therefore VP3 is a predicted multifunctional capping enzyme [1]. 	18.10	18.10	52.30	52.30	17.00	16.20	hmmbuild  -o /dev/null HMM SEED	684	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.49	0.70	-13.31	0.70	-6.64	3	582	2009-01-15 18:05:59	2003-08-13 11:02:47	6	3	240	0	0	463	0	551.40	85	83.42	CHANGED	MKVLAL.RRulspsYADTQVYsHDssKDYYENAFLISN.lTTHNILYLD.YSI....KslEILNKSGIAALIhIshD+LtILI+SNFTYDYphcIVYLHDYSYYsNNE.IRTDQaWLTpTNIEEYLLPGWKLTYVGpsGpETRGHYsYSFhCQNTATDDDIIY-YIYS.....NulDF.........pNFlLptlpcRMTTAVPFcRLSNRIFR-+LFS...K..KssINIGPRNESMFThLc..YPpIpNYSANualVSDLI+LsQE+WlGK+ISQFDIGQFKNMhNVLTsIYYYYNhYKuKPpIYMIGSAPSYWIYDl++Y.sFsIETWDPLDTPaSocHHKchFsIsDlcKLKDNSILYIDIRSDRssADWRcWRKpVEEETIpNLEIuYKYLcsGKs+lCClKMTAMDlELPhouhLLHaPTTcI+SEaYLLlDpahLpcpKRFVPKGlhYSFINNIhTDNVFISssYKVKspN-.aVVALYuLSN-hNsR-KVIcasNsQKpolITVRlNNTFcsEh+lsFKosYDaTFLPSDFosc.sTIlTSYDGYlGlFGLSISL-SKuTGNNHLFIlsusccYsplDoFuoHhGISRRSHSlRFSESATThSGYIFRDloNGKFNLIsTNlENuVSGHVYNALlYYRYNYoFDLlRWIpLHupDcVcIcGG+YYEHAPsELlYACcSAhVFApLQsDLTll+YSNclpcYIpsp	...........................MKVLAL.RHSVAQVYADTQsYlHDDSKDEYENAFLISN.LTTHNILYLN.YSl.....KTLcILNKSGIAAVElQS.DELFs.LIRCNFTYDYENNIlYLHDYSYYTNNE.IRTDQHWITKTDI.DYLLPGWKLTYVGYNGKsTRGHYNFSFhCQNAATDDDIIIEYIYS..............NELDF.........QNFLLRKIKERMTTSLPIARLSNRVFRDKLFPSlVshacKVIN.VGPRNESMFTFLN...FP.TIKQFSN..GAYlVKH.TIKLKQE+WLGKRVSQFDIGQYKNMLNVlTTIYYYYNLYaSKPIIYMLGSAPSYWIaDlKQY.SDFpFETWDPL..DTPYSo.h......HHKELFa.pD.VsKLKDNSlLYIDIRTDRtNhDWKEWRKlVEpQTlsNLNIAYKYLuTGKAKVCCVKhTAMDLELPIoAKLLHHPTTElRSEFYhIlDlWDhhs.I.KRFIPKGVhYuaINNlhTENVFIQ....PF...KLKs.p.s-...YIVALYALSNDFNsR...pDVIpLINpQKpuLI....TVR........hNNTFKDEPKVsFKNIY......DWTFLPTDFEhp.-SIITSYDGCLGhFGLSISLuSKPTGNNHLFIlsGTDKY.KLDQaANHMuISRRSHQIRFSESATSYSGYIFRDLSNN.NF..NLIGTNVENSVSGHV......YNALIYYRYNYsFDLKRWIYLH.ShGKsulEGGRYYEHAPIELIYACRSA+EFAhLQDDLTVLRYuNEIEtYINK.V........................................................	2	0	0	0
+6758	PF06930	DUF1282		Protein of unknown function (DUF1282)	Moxon SJ	anon	Pfam-B_14843 (release 10.0)	Family	This family consists of several hypothetical proteins of around 200 residues in length. The function of this family is unknown although a number of family members are thought to be putative membrane proteins.	23.40	23.40	23.60	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.39	0.71	-4.60	19	937	2012-10-01 22:34:14	2003-08-13 11:06:06	7	8	874	0	113	703	106	178.10	39	84.19	CHANGED	llspPupp.applcpcccshthhhlhhllhhhlhs.ssshhhssh..hhthhst.............s.phohts....uhhhulhshhhh..hhhlhuhh...hphhschas..upss...hppshhhuuYsssPhhluuhsshh.slhhsh.............................shhlhhsaslhLlahGl.hhh..sl.cppcuhhhssh.....hllhsl	.................................................................LaoHPscE.hpsIp..p.Es.E.ol.u+.a....Ys.a..HV..LLhA...u....IP...VlC.....Aa..I..G.T..T.QlGW.s.hG-G.s......................l.pLohho...........ulslAVlhYslhL.....AGVAlMGtl.....I.aW.M.A.RsYs..p+PS.....ls.+ChlFAGYs...AT...PL.F...L.u.GL..V.AL..YPllWLsu..........................................................llGslAL.h.YosYLLYLGlPoFh....sI....s+.-EGl.FSSSsl....ulGl.....Llltlhhh.h.................................	0	19	46	85
+6759	PF06931	Adeno_E4_ORF3		Mastadenovirus E4 ORF3 protein	Moxon SJ	anon	Pfam-B_14868 (release 10.0)	Family	This family consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). The function of these domains is unclear, but PODs have been implicated in a number of important cellular processes, including transcriptional regulation, apoptosis, transformation, and response to interferon [1].	25.00	25.00	37.60	37.60	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.53	0.71	-4.02	7	84	2009-09-11 07:31:22	2003-08-13 11:13:02	6	1	67	0	0	45	0	111.80	67	97.19	CHANGED	CLRMsVEGALpcLFsMpGhsLpp.hhcIIptW+sENYLGhVQsCuhMIEEh-ss.uFulllFL-VRV.sLLEAsVpHLENRlhFDLAVhFHQcSGG-RCHLRDL+FplLtsRLE	.....CLRMpVEGALpELFpMsGlDLppphscIIQGWKNENYLGMVQ-CshM.I..-El-su.uFsllLaLDVRVEsLLEATVEHLENRlsFDLAVhFHQHSGG-RCHLRDLHFpVLRDRLE................	0	0	0	0
+6760	PF06932	DUF1283		Protein of unknown function (DUF1283)	Moxon SJ	anon	Pfam-B_15035 (release 10.0)	Family	This family consists of several hypothetical proteins of around 115 residues in length which seem to be specific to Enterobacteria. The function of the family is unknown.	25.00	25.00	94.50	31.80	22.40	17.80	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.88	0.72	-3.96	9	515	2009-01-15 18:05:59	2003-08-13 11:31:22	6	2	510	0	40	138	1	84.80	85	74.80	CHANGED	sTs+lVl-SGDoAhS+psAp.sKEQWNDT+uLRpKVNpRsEKEaDKhDtAhDu+DpCppSsNlNAYWEPNT.RCLDRRTGRs.IsP	............ETsKLVIESG.DSAQSRQcAAMEKEQWNDTRsLRQKVNKRsEK.......EWDKADAAFDNRDKCEQSANINAYWE....PNTLRCLDRRTGRV.ITP......	0	1	8	23
+6761	PF06933	SSP160		Special lobe-specific silk protein SSP160	Moxon SJ	anon	Pfam-B_14947 (release 10.0)	Family	This family consists of several special lobe-specific silk protein SSP160 sequences which appear to be specific to Chironomus (Midge) species [1,2].	25.00	25.00	25.80	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	756	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.58	0.70	-6.55	2	5	2009-01-15 18:05:59	2003-08-13 11:37:41	6	2	3	0	1	5	0	618.40	65	77.63	CHANGED	MNIKVILVCALVAIFFAQVAEGGPIANFVGFlISLLFSLFEVMlSVVFDVKSFTSLSssTsNuThPuFAopVGGGRFosIhpuoFNhIAMISANlQAIQSGSGSsSusSSSSssSTosSsoTTSssoTTooNSTT.......SSNSTSSGLTouASVVSLIDThAWVYQDSSVGIAYLMVSILALFYGQSVSAPPYsDLGIPALPANsSGsGVPQSVQI+AAIsYlNlTI.FIshTGQQFEDLQGPVsTDCGCPNTTSVAPLVhEWEAIhAALpAhAsuoASuNSTosSsSTosoTTsSsSTTTTNSTToTNSTSSSNSoTIAGsIDIuANhTlALQsLQALLhQEuTCAPsLAANAKKSGVR-huPCKsu..uSuCA+SGp+KVKRKARLEKMRAKsRRAVGNR.KGSMKKRVRSRAKKFGcAAKSGVRRYRKNIKaVYIPPVMASLNAYAALMASLS-SIS.QS-SALNSTDpACNSTussTDtAVIsATssVTDMFsNFTAMVlNNTVAaPNCTQaADMAL.MlSQIN-QIIuCGSQSDsApSSIYhNVTIsIVAMAQEYNNFASMSDKCTRSFANSWLWMYIKWVFYRMGMTSGlPNFLACQTKApSSLTAhLASFNATlsATIuAASANsSpVQSSEAuCIESSLu-AusILtMaEsAYQNCssPGSV..PstssTTTooTTTTTTTTTTAAPTTTTTKAANAPFTYPLCsL.MossCshGhssCTYPhISSAGCCPSGKTLNTGLGGRGCCK	.........MNIKVILVCALVAIFFAQVAEGGPIANFVGFlISLLFSLFEVMlSVVFDVKSFTSLSsPTsNuThPuFAopVGGGRFosIhpuoFNhIAMISANlQAIQSGSGSsSusSSSSssSTosSsoTTSssoTTooNSTT.......SSNSTSSGLTouASVVSLIDThAWVYQDSSVGIAYLMVSILALFYGQSVSAPPYsDLGIPALPANsSGsGVPQSVQI+AAIsYlNlTI.FIshTGQQFEDLQGPVsTDCGCPNTTSVAPLVhEWEAIhAALpAhAsuoASuNSTosSsSTosoTTsSsSTTTTNSTToTNSTSSSNSoTIAGsIDIuANLTlALQNLQALLhQEuTCAPsLAANAKKSGVR-huPCKsu..uSuCA+SGp+KVKRKARLEKMRAKCRRAVGNR.KGSMKKRVRSRAKKFGKAAKSGVRRYRKNIKaVYIPPVMASLNAYAALMASLS-SIS.QS-SALNSTDpACNSTussTDtAVIsATssVTDMFsNFTAMVlNNTVAaPNCTQaADMAL.MlSQIN-QIIuCGSQSDsApSSIYhNVTIsIVAMAQEYNNFASMSDKCTRSFANSWLWMYIKWVFYRMGMTSGlPNFLACQTKApSSLTAFLASFNATlsATIuAASANsSSVQSSEAuCIESSLuDAAsILtMaEsAYQNCoAPGSV..Ps-T.sTTTTTTTTTTTTTTTAAPTTTTTKAANAPFTYPLCsL.MossCshGhssCTYPhISSAGCCPSGKTLNTGLGGRGCCK.......	0	1	1	1
+6762	PF06934	CTI		Fatty acid cis/trans isomerase (CTI)	Moxon SJ	anon	Pfam-B_14967 (release 10.0)	Family	This family consists of several fatty acid cis/trans isomerase proteins which appear to be found exclusively in bacteria of the orders Vibrionales and Pseudomonadales. Cis/trans isomerase (CTI) catalyses the cis-trans isomerisation of esterified fatty acids in phospholipids, mainly cis-oleic acid (C(16:1,9)) and cis-vaccenic acid (C(18:1,11)), in response to solvents. The CTI protein has been shown to be involved in solvent resistance in Pseudomonas putida [1].	25.00	25.00	26.10	34.10	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	694	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.53	0.70	-13.15	0.70	-6.28	33	247	2009-01-15 18:05:59	2003-08-13 11:44:16	6	2	227	0	54	225	50	647.60	51	88.45	CHANGED	AssPTRLF.lDApssppWRp+GFasVLs...ps.tushpAuLhh+MLpLKpppPLsssshL.s-shDhulsRsppCPs..cEassYtpspPptGMPaGhPuLossEassLtpWLppGA.....shstps.s.ospEtppIspWEsFLNpsuhKppLsARYlYEHLFLAHLYF..........tssp...sscFFcLVRSpTPsGpPlchIuTRRPaDDPGsc...........hYYRLhPlpuoIVcKTHhsYsLssp+LpRhppLFhss-a.pVspLPuYpsphuANPFpoFpsIPscARYpFMLDpApahlhsFIKGPVCRGQlALNVIpD+FWVhFhcP-ps.hsssssahpppsshLtLPupt-ssss.hhs.WhpYuc...ppscYhcs+pphhschh.ts....hshshlWsGs.s.NcNAhLTlFRHFDSASVhKGLlGphPKTsWllDYPLLERIaYhLVAGFDVYGNVuHQL.TRLYMDhLRhEGEsNFLpLLPtcpRcshhssWYpssu.plpp.alpts..hshspPoulpapos.sPKpEhhpplhp.+hsslts.sp.sls...sst..............hppscph...Lsplsuhtus.ulsh...LPE....lohlhl................csssG..cpp.lYSLl+NpAHsNluhLhuEchchpPppDoLTlh.GllGSYPNhhapl.pps-lssFVstlpshcsppD.a.ppll-+aGlRRosPpFWpa.Dplpphh+pspPlEuGlLDhNRaENc	...................................................................................................................AssPTRLa..DApsTppWRptGFaPVLs...ps.tuNhpAulhARhL..KcppPLPtpspL..cshDhSlsR.pppCPo..pEh-patpspPphGMPaGhPsLospEYsTLhpWLppGA......shspth....shospEts.lspaEshLNpsutKppLsARYlYEHLFLuHLYF..............s.tp.ps+FFpLVRSpTPPGp..............PlchIsTRRPaD.DPGs-..........+lYYRLhP.QsTIVcKTHhPasLspp+ltph+phFlssDY.pV.spLPuYpPphuANPhpsFhslPscARapFhLDNAp.hlhuFIKGPVCRGQlALNVIpD+FWVhFhDP-+sph.spsspFhtppsstLpLPupp-sssh.slo.W.l..pYut...ppscYhcA+s-hhsphhtsG....lohshlWcGs...s.NsN.AsLTlFRHFDSASVlpGLlG-sPKTsWlhDYsLLERIHYLLVAGFDVYGNhGHQLhTRhaMDaLRhEGEsNFltLLPtDhRcp.husWYQspu.phptal.pts.shsh-pPTulpa.oc.sPKpELhtpLtc.pltsl.u.sc.sIs...pst.............hhtpsEts...Lpplsphtut...GLhs.......lPp.......lsMLhl................cspp.G....ctp...laTLl+NpAHoNlutLhsEptpt...pPtpDsLTll.GVlGSYPshhhsl.pp.splsphsptltshcs-.pDY..tLl-+aulRRSsPpFWsauDtlppah+pspPlEhGlLDhNRaEN.........	0	11	26	42
+6763	PF06935	DUF1284		Protein of unknown function (DUF1284)	Moxon SJ	anon	Pfam-B_14822 (release 10.0)	Family	This family consists of several hypothetical bacterial and archaeal proteins of around 130 residues in length. The function of this family is unknown, although it is thought that they may be iron-sulphur binding proteins.	25.00	25.00	25.30	26.60	24.00	22.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.83	0.72	-3.85	30	215	2009-01-15 18:05:59	2003-08-13 11:48:14	6	2	214	0	76	160	6	105.20	33	74.01	CHANGED	GYSssFlcNhscIhpcl.t...ppstpIplVsssDcICtsCPsptcst.Cp....sps...pVpchDc....pVlchL...slcsGphhshschhppltcphps.sclcclCpsCcWhphsh	......GYSssFVcNhctIst.+L.....spspsIplVsusD-ICsshsst.s.csp...Cp............s-s......VpthDc......tVhchL......uLc........sGc...hph.s.p.hht.p.h.hcchhs.sslcchCpsCpW.sls.........	0	25	52	62
+6764	PF06936	Selenoprotein_S		Selenoprotein S (SelS)	Moxon SJ	anon	Pfam-B_15061 (release 10.0)	Family	This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types [1]. The function of this family is unknown.	21.30	21.30	21.50	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.48	0.71	-4.76	5	99	2009-01-15 18:05:59	2003-08-13 12:01:14	6	4	75	1	58	110	0	156.90	34	90.36	CHANGED	M-.hcD-sshsNc.lPshEspuL..sFLpsoVGphLSpYGWYLLlGCVllYlLIQ+Lst+h.RulpsRpoptshospDP-pVVRRQEAlEAARhRMQE-LDA+AscFKEKQ+QLEEEKRRQKIEhWDRMQEGKSYK.sSu+lsp-uosEsSoSSul.KPKo...EKKPLRuoGYNPLTGsGGGSCSWRPGRRGPSSGG	..............................h...........................h..sls.hLusYGWYll.hsslllYllhp+.lptc.h...+......shp.p...pp....p..t.s...t..s.s....h-P-sVs++QEAlt....AARh+.MQEELsAp..s..c....ca....+...EK....+phEEEK......R+pcI......chW-shpp..G+u.h+..st.p.....tppss..tsu......suosh.K.K....cp+sL.RsusY..NPLsGp.uGussuaRPs+Rs.sstGG.....................................................	1	25	28	42
+6765	PF06937	EURL		EURL protein	Moxon SJ	anon	Pfam-B_14914 (release 10.0)	Family	This family consists of several animal EURL proteins. EURL is preferentially expressed in chick retinal precursor cells as well as in the anterior epithelial cells of the lens at early stages of development. EURL transcripts are found primarily in the peripheral dorsal retina, i.e., the most undifferentiated part of the dorsal retina. EURL transcripts are also detected in the lens at stage 18 and remain abundant in the proliferating epithelial cells of the lens until at least day 11. The distribution pattern of EURL in the developing retina and lens suggest a role before the events leading to cell determination and differentiation [1].  	22.00	22.00	22.20	23.80	20.60	21.90	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.99	0.70	-4.98	6	69	2009-01-15 18:05:59	2003-08-13 12:32:25	6	2	45	0	39	56	0	244.50	59	93.19	CHANGED	MpEEEQFVsIDLNDDNICSVCKLGTDp-TLSFCHlCFELsIEGVP+SsLLHTKSLRGH+DCFEKaHLIANQDCsRSKhS+SsYEtVKsIlSKKINWIVQYAQNKDlso-oEsSKsoQH.LhsaRHQs-+KLLPQ.DSQVPRYSuKWh.EuNuuuhSshuQplLEp+csp-FsLGhLppssst......LWs.sp.spsQKpEpssSus.sp.QRpasHaSREEL.NpMoltEL+QLstpLLpQIQ-VFEELottVQEKDSLuSELHVRHlAIEQLLKNCSKLPCLQhGRAGhKu	...............................................................................MNEEEQFVNIDLNDDNICSVCKLGTD+ETLSFC.HlCFELNIE...GVPKSsLLHT+SLRGHKDCFEKaHLIANQcCP............RSKLSKST.YEEVKoILSKKINWIVQYAQNKDlDSDSECSK...ssQH.pL...hsFRH+s-cKLLPQFDSQVP+YSAKWl.-GssuulSsps.QpIL...EppcssDFtLuhLpsssus..........LWs.sp.s.psQ+pEcs.us..stsssppp.p.+YSREEL.ssMolsElcQLsscLhpQIQ.-VFE-LsttVQEKDSLuSpLHVRHlAIEQLlKNhSKLP....pLQh.GRs.Gh+....................................................................	0	7	9	19
+6766	PF06938	DUF1285		Protein of unknown function (DUF1285)	Moxon SJ	anon	Pfam-B_15060 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. The structures revealed a conserved core with domain duplication and a superficial similarity for the C-terminal domain to pleckstrin homology-like folds. The conservation of the domain- interface indicates a potential binding site that is likely to involve a nucleotide-based ligand, with genome-context and gene-fusion analyses additionally supporting a role for this family in signal transduction, possibly during oxidative stress.	25.00	25.00	32.20	31.20	24.90	24.30	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.93	0.71	-4.23	81	468	2009-01-15 18:05:59	2003-08-13 12:35:09	6	2	462	3	150	424	462	143.40	43	74.16	CHANGED	hcItpDGoWaYpGoPIsR.sLV+LFSolL++-s-....caaLVTPVEKlsIpVEDAPFlAV-hchp.t.puptp.sLpFpTNluDhlhsG.s-HPLRlp...............................hssps..sEs.sPYlpVRss......L-AhlsRslaYcLl-luppps...stshhulhSuGthFs	...hcIptDGoWaY.GoPIsRtsLV+LFo.olL.++-sD.....caaLVTP.VEKlsIcV-DAPFlAV-hchp.s.ps....psp.s.LpFpT.NlsDhlpsss-H.PLRht...............................hpsts.....sp..pPYltVRss......LcAhlsRslaYcLVph.upttc..........pG.thhulhSuGthF......................................................................	0	44	85	116
+6767	PF06939	DUF1286		Protein of unknown function (DUF1286)	Moxon SJ	anon	Pfam-B_15105 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of around 120 residues in length. All members of this family seem to be Sulfolobus species specific. The function of this family is unknown.	25.00	25.00	32.50	45.10	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.83	0.71	-3.90	8	53	2009-01-15 18:05:59	2003-08-13 12:41:15	6	1	24	0	15	48	0	109.80	56	66.48	CHANGED	MKLpTHYVFohGLLTLlsShhh.......sFYhSLllSullSllGNoLIDRLGHpEIpspYGh.IssRTPLTHThPRSlhWGLlsulP.lIhhLtahYGa...........phlhhlLlsGllsGPSHMLL	...........M+L+THYlFSsGLLTLLsShlh.....p.FYhuLllSullSVlGNoLIDRlGH+EItT+YGh.IPVRTPLTHTlPRSVlWGlloslP.hIlLLhaaYGh...........ppllLllLLsGVlVGPSHMLL.	0	4	6	14
+6768	PF06940	DUF1287		Domain of unknown function (DUF1287)	Moxon SJ	anon	Pfam-B_15116 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown. This family is related to Pfam:PF00877.	25.00	25.00	38.30	38.20	22.00	19.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.24	0.71	-4.83	25	504	2012-10-10 12:56:15	2003-08-13 12:43:34	6	2	497	0	44	231	32	160.30	69	78.88	CHANGED	llsuAcpplsssltYDsuYhplsYPsGDVPtspGVCTDVVlRAhRp.hslDLQchVHEDM+pNFusYP..+hWGLp+PDsNIDHRRVPNLpsaFpRputsLslotss.......p-YpsGDIVoWtL.sss.LsHIGIVSD+cpssGh.PhllHNIGsGsp..EEDhLFpa....cI...sGHYRa	............IADGARpQIGsTLFYDPAYhpLoYPGGDVPpERGVCSDVVIRALRS.QcVDLQKLVHEDMAKNFApYP..QKWpLKRPDSNIDHRRVPNLETWFoRHsKT.....+PhSKNs.......SDYQAGDIVSWRLDN....G....LAHIGVVSDs.hA..R.D.GT.PLVIHNIGAGAQ...EEDVLFuW....+M...VGHYRY......	0	17	30	38
+6769	PF06941	NT5C		5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)	Moxon SJ	anon	Pfam-B_14848 (release 10.0)	Family	This family consists of several 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C (NT5C) proteins. 5'(3')-Deoxyribonucleotidase is a ubiquitous enzyme in mammalian cells whose physiological function is not known [1]. 	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.28	0.71	-4.79	6	770	2012-10-03 04:19:28	2003-08-13 13:06:10	7	7	677	18	215	585	488	168.80	25	85.77	CHANGED	R.lhlhVDhDGVhADFhGthlphasccFtcs..lh.E-hpu.ashcpaG.hpPspt-plapa.hpp.uFFtsLEPlPGAh-sL+clusht.c.VhIsssshh+Y.H..ult-KhpWl-pHhshl.htsllls+-KslVtuDlhIDDpPcNltphps.sh.pILFsssaN+Hlc...sphRssSWp-sachI..lpuKth	.....................................................................p....lslDhDtVLsDh....hst....hl....ch...hs..........at....t..p........l..p.........h.c..t..h....p...s.....h......h...c.t.......................-..ht.....t.h......h..hph...h.cp..s.s..a...F..p.......p...l...c.s...h..P.s.A....E...sl.+cLs.c...p.........h...........l.a.I.so.sshch.p..............sh.p..-........K...h.c..W.Ltc.a....hs........h..........l....s.............p.....c..h...l.....h..........s.....t.........c.......K.......s..........l.........l.........p......u...........D........h....L........IDD..pPcp..h.......t................h..t..s..t.s.......lha.ss......saN..p...p...........h.RlpsW..p-h.t..........ph....................................................................................	0	84	130	168
+6770	PF06942	GlpM		GlpM protein	Moxon SJ	anon	Pfam-B_15323 (release 10.0)	Family	This family consists of several bacterial GlpM membrane proteins. GlpM is a hydrophobic protein containing 109 amino acids. It is thought that GlpM may play a role in alginate biosynthesis in Pseudomonas aeruginosa [1].	25.00	25.00	25.10	27.50	22.20	24.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.27	0.72	-3.79	14	669	2012-10-01 21:19:26	2003-08-13 13:30:26	7	1	664	0	57	200	0	106.30	68	95.42	CHANGED	lKsLlGAhsVLlIulLSKoKsaYIAGLVPLFPTFALIAHYIVGoERuh-sLRsThlFGlaSlIPYhsYLhulYYFohhhpLstsLssAslsWllsAslLlhsWs+hp	....IKAALGALVVLLIGlLuKTKNYYIAGLIPLFPTFALIAHYIVASERGIEALRsTIlFSMWSIIPYFlYLloLWYFoGhMRLPsAhlGuVsCWGlSAWlLIhCWIKhH.........	1	7	19	38
+6771	PF06943	zf-LSD1		LSD1 zinc finger	Moxon SJ	anon	Pfam-B_15249 (release 10.0)	Domain	This family consists of several plant specific LSD1 zinc finger domains. Arabidopsis lsd1 mutants are hyper-responsive to cell death initiators and fail to limit the extent of cell death. Superoxide is a necessary and sufficient signal for cell death propagation. LSD1 monitors a superoxide-dependent signal and negatively regulates a plant cell death pathway. LSD1 protein contains three zinc finger domains, defined by CxxCxRxxLMYxxGASxVxCxxC. It has been suggested that LSD1 defines a zinc finger protein subclass and that LSD1 regulates transcription, via either repression of a pro-death pathway or activation of an anti-death pathway, in response to signals emanating from cells undergoing pathogen-induced hypersensitive cell death [1]. 	20.20	20.20	20.30	20.20	19.70	20.00	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.87	0.72	-6.91	0.72	-4.33	23	365	2009-09-10 17:13:47	2003-08-13 14:14:43	7	6	52	0	186	373	2	25.00	54	21.25	CHANGED	Cs....GCRslLtYPhGAsuVRCuhCpsV	.......Cu....uCRslLhYPhGAs..SV+CulCpsV..	0	32	115	160
+6773	PF06945	DUF1289		Protein of unknown function (DUF1289)	Moxon SJ, Eberhardt R	anon	Pfam-B_15170 (release 10.0)	Family	This family consists of a number of hypothetical bacterial proteins.  The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N-terminus. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	20.20	20.20	20.30	20.50	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.81	0.72	-4.49	164	1514	2009-01-15 18:05:59	2003-08-13 14:58:21	8	8	1024	0	413	1099	1383	49.30	37	55.23	CHANGED	pSPClslCphst.sslChGChRoh-EItpWpphsssc..+ptlhp..plstRtst	.............SPClu..lCph-t.........pshCpGChRot-ElhsWpphocsc..+ptVhp.hhppRh..h..................	0	68	178	296
+6774	PF06946	Phage_holin_5		Phage holin	Moxon SJ	anon	Pfam-B_15309 (release 10.0)	Family	This family consists of several Listeria bacteriophage holin proteins and  related bacterial sequences. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis [1].	22.40	22.40	22.90	22.60	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.13	0.72	-3.82	2	44	2009-09-10 23:38:34	2003-08-13 15:04:36	6	1	41	0	4	35	2	88.70	41	94.32	CHANGED	MEFGKELLVYMTFLVVVTPVFVQAIKKTELlPSKWLPTVSILlGAILGALAT.LDGSGSLATMIWAGALAGAGGTGLFEQFTNRuKKYGcDD.	.............................plLhahohLsllssl..h..VQuIKK.T.cl..lPsKalPsVSlllGslLGAlAs.lss.ss.sLsshlWA...Gu....lAGhuuTGLFEthTp..R..........................	0	1	1	4
+6775	PF06947	DUF1290		Protein of unknown function (DUF1290)	Moxon SJ	anon	Pfam-B_15248 (release 10.0)	Family	This family consists of several bacterial small basic proteins of around 100 residues in length. The function of this family is unknown.	24.40	24.40	39.60	39.60	24.30	24.30	hmmbuild  --amino -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.95	0.72	-4.08	36	498	2009-01-15 18:05:59	2003-08-13 15:07:14	7	1	497	0	137	265	5	88.80	52	78.09	CHANGED	slPstausYLulAllAALDolFGulRAtl-cpFDsclFloGFFuNslLAuhLsaLGDpLGV.s.LahAuVlVFGlRlFsNhAhIRRhLlc	.......lPsshpPYLsIAllAALDAlFGulRAhLccpFcs+VFVsuFhuNVllAALlValGDpLGV..s.L.sAslVVhGlRIFsNsAuIRRhlh.t.......	0	58	106	124
+6777	PF06949	DUF1292		Protein of unknown function (DUF1292)	Moxon SJ	anon	Pfam-B_15310 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	21.30	21.30	21.30	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.77	0.72	-3.63	79	1823	2009-01-15 18:05:59	2003-08-13 15:12:29	6	4	1459	0	278	887	96	76.20	32	73.45	CHANGED	EpGsEhphpllhsh-s.-..s.ppYlllhPht......pp.-p....t...-lhhhph.tp...--s...spttLhsl..EsD.-Ea-hVtcshpshh.sE	.............EpGNEp..ha-llh.sh-s.E.....s.KpYllLhPss..............tp----.............ph...El.shph.ts...--s.....sp...u.cLtsI...EsD..-EW-hlpElasohh-E.......................	0	123	207	245
+6778	PF06950	DUF1293		Protein of unknown function (DUF1293)	Moxon SJ	anon	Pfam-B_15399 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 115 residues in length. The function of this family is unknown.	25.00	25.00	25.00	36.00	24.50	15.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.31	0.71	-4.19	4	44	2009-01-15 18:05:59	2003-08-13 15:18:40	6	1	39	0	3	27	0	108.10	62	98.04	CHANGED	MA+s.VFVLGIsIhWNstpG-p.ApLNlSRPL+pVNuEKFKRRTlGEsGDVNPpaDQPLhID+cYAh+LE+oGAhVPRREY-lcltlNP-DPLAGuIVsELIPVDsElKKHFpASLK	.........MAp....lhGhsIph.stpG....so.ApLNV.RPlcpVNsEKFtphslG.ssDl.P..cQPLhI-.sYAhhL.cTtAhVPpREYplRht.NP-DPLt.slssELIPhDp-lKKaFptohK..........	0	0	0	1
+6779	PF06951	PLA2G12		Group XII secretory phospholipase A2 precursor (PLA2G12)	Moxon SJ	anon	Pfam-B_15422 (release 10.0)	Family	This family consists of several group XII secretory phospholipase A2 precursor (PLA2G12) (EC:3.1.1.4) proteins. Group XII and group V PLA(2)s are thought to participate in helper T cell immune response through release of immediate second signals and generation of downstream eicosanoids [1]. 	32.50	32.50	32.90	37.40	28.00	32.30	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.55	0.71	-4.65	8	176	2009-01-15 18:05:59	2003-08-13 15:23:26	6	5	97	0	98	157	1	169.50	40	81.12	CHANGED	sLuL.hL........ssutusc............EscssDWhhsLpoIRsGl+plcsYhsuAL-LlGGcDGlCQYKCpsGps.....PlPRPGY+sP.PNGCGS.hFGl+....hDl.GIPu..MTKCCNQHDhCYDTCGpsKpcCDpcFphCLcsICsDlpKoLGhspsVc.ACEosVchLFsoVhpLGCKPYL-SQRuAClCphEEKsEL	.............................hhhhhhh.................................pt.hsDh..sltslRsuhcplptYhsuhl-Lh.G...G.psGhC.p.Y.+....Cp.......Gpt.....PhP..R....uY+sstPNGCG...S.hhGlp....hsh.GIP..u..hTKCCNpHDhCYDTC........Gs.sKtcCDtcFphCLppIC..s..cl...p+.o..L......G..............hsppVp.......A.C-osschlFssVh.p.LGC+Pa..hsSQ.RsAChCt.E-+t-L...........................	0	25	39	62
+6780	PF06952	PsiA		PsiA protein	Moxon SJ	anon	Pfam-B_15432 (release 10.0)	Family	This family consists of several Enterobacterial PsiA proteins. The function of PsiA is unknown although it is thought that it may affect the generation of an SOS signal in Escherichia coli [1].	25.00	25.00	27.70	27.70	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.62	0.70	-5.30	7	330	2009-01-15 18:05:59	2003-08-13 15:30:40	6	2	215	0	9	171	0	217.40	69	97.79	CHANGED	M.spSpALVsLpstpQAAhpAlhhsEppRcpGspLsuhPas+sFhRlL.sGSuRIssoshRpIsuhhhsscp+hssL.Qh.tALDhLIpStGEhCPLPLohDVtucLFPpVhatcs-RRhp+pslshpRp.RpcuRcsEQphhhhQNLLuQA.sELsFpSPETVsoWYsRWSDc.h-tp-LtshFWpWpsRFsSLsuh-hhphps-PLatVMaEl.hhsREssctlRthERW.VPNKLts	.........MSARSpALVPLSsEQQAAhpAVApTEcRR+QGsTLu..taPYAuAFFRCL.NGSRRISLoDLRFFhPuLTsEEhHGNRL.QWLhAlDhLIEopGEVClLPLPuDAucRLFPSVhFRhpERpR+KosLsh..QKYSRQpsREAEQ+thtYQsLlAQApIELAFHSPETVGSWauRWSDc.Vs.....EHDLETlFWpWspRFPSLuuh-RapWQ-.PhWpVIhEAuhAuR-AsctVRphERWMVPNKLc.p....................................................	0	1	1	6
+6781	PF06953	ArsD		Arsenical resistance operon trans-acting repressor ArsD	Moxon SJ	anon	Pfam-B_15383 (release 10.0)	Domain	This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)-Cys(113), that potentially form separate binding sites for the metalloids that trigger dissociation of ArsD from the operon. However, as a homodimer it has four vicinal cysteine pairs [1].	20.70	20.70	20.70	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.58	0.71	-3.95	38	439	2012-10-03 14:45:55	2003-08-13 15:32:12	6	7	386	8	103	319	11	115.90	37	90.33	CHANGED	Mp+..lplFDPAhCCSTGVCGs-VDppLlpFuADlcWl.KppGlplcRaNLuppPhuFscNssVpshLcpuGt-sLPllLVDGpllhsGcYPoRpEL.....spahGlshspstts...........................ssuC.Cuusst....CC	..........................................................MpplplF-PAhCCSTGVCGsplD.tLlphusshphl...+.p..p.........Glp.lpRaNLuppP.tFspNptVpphLpppGt-sLPlhLVDGclshsGpYPopcEl.....ucahulsh.p.........................................sssC....Cu.st.......CC........................................	0	45	72	86
+6782	PF06954	Resistin		Resistin	Moxon SJ	anon	Pfam-B_15476 (release 10.0)	Family	This family consists of several mammalian resistin proteins. Resistin is a 12.5-kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes. It belongs to a multigene family termed RELMs or FIZZ proteins. Plasma resistin levels are significantly increased in both genetically susceptible and high-fat-diet-induced obese mice. Immunoneutralisation of resistin improves hyperglycemia and insulin resistance in high-fat-diet-induced obese mice, while administration of recombinant resistin impairs glucose tolerance and insulin action in normal mice. It has been demonstrated that increases in circulating resistin levels markedly stimulate glucose production in the presence of fixed physiological insulin levels, whereas insulin suppressed resistin expression. It has been suggested that resistin could be a link between obesity and type 2 diabetes [1].	25.00	25.00	25.30	25.90	23.70	24.80	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.20	0.72	-10.72	0.72	-3.71	11	72	2009-01-15 18:05:59	2003-08-13 16:39:31	6	2	28	12	30	67	0	82.10	54	76.16	CHANGED	ssopCol-pll-cKIK-sLuphp..Pssl.....pKp.LSCsSVpopG+LASCPuGhsVTGCuCGauCGSWDIppcsTCHC.QCu.sl..DWTsARCCpL	..................sto.ssl-phlpcKIp-hhssl......psl........pph.LpCpSVpSpGcLAoCPsGhsVTGCuCG.uCGSWDlR.s.-TTCHC..QCu....sh..DWTsARCC+l...	0	6	6	7
+6783	PF06955	XET_C		Xyloglucan endo-transglycosylase (XET) C-terminus	Vella Briffa B	anon	Pfam-B_20045 (release 10.0)	Family	This family represents the C-terminus (approximately 60 residues) of plant xyloglucan endo-transglycosylase (XET). Xyloglucan is the predominant hemicellulose in the cell walls of most dicotyledons. With cellulose, it forms a network that strengthens the cell wall. XET catalyses the splitting of xyloglucan chains and the linking of the newly generated reducing end to the non-reducing end of another xyloglucan chain, thereby loosening the cell wall [1]. Note that all family members contain the Pfam:PF00722 domain.	20.50	20.50	22.20	21.10	19.20	17.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.04	0.72	-4.26	134	896	2009-01-15 18:05:59	2003-08-13 17:05:34	7	5	108	13	411	924	0	52.80	34	18.85	CHANGED	C................sssssW.hs.pp......Ls..spptpph+WVpppaMlYsYCsDppRaPts..hPs.EC	..............................ttsttW.hs..pp........Ls.sppppphcWVpppaMlYsYCsDpp.R.aPt......s...hPs.EC........	0	61	251	337
+6784	PF06956	RtcR		Regulator of RNA terminal phosphate cyclase	Studholme D	anon	Pfam-B_17814 (release 10.0)	Family	RtcR is a sigma54-dependent enhancer binding protein [1] that activates transcription of the rtcBA operon. The product of the rtcA gene is an RNA 3'-terminal phosphate cyclase [2]. This domain is found at the N terminus of the RtcR sequence. RtcR, and other sigma54-dependent activators, contain Pfam:PF00158 in the central region of the protein sequence.	22.70	22.70	22.80	23.00	21.20	22.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.19	0.71	-4.95	17	470	2009-01-15 18:05:59	2003-08-13 17:23:00	6	3	455	0	52	277	17	182.20	74	34.98	CHANGED	h++pVslGFLGosLD.....tGpuspRWp+WRPoVuLCQp.D.L.lDRLELLH..ss.................RtpsLA-pltpDIspVSPcTEVchp.hplcsPWDFcEVYusLaDFscuYsFDsEpE-YLlHITTGTHVAQIChFLLsEuRalPA+LlQTSPsRc...ptppssGohslIDLDLSRYDpIAsRFspcpp-sluFLKSG	.......................MRKTVAFGFVGTVLD....YAGRGSQRWSKWRPTLCLCQQ.ES.LVIDRLELLH..Ds.................RSRSLFETLKRDIASV.SPETEVVuVEIELHNPWDFEEV...YACLHDFARGYp..FQPEKEDYLIHITTGTHVAQ.ICWFLLAEARYLPARLIQSSPPRK.......KEp.P.+....usG-VTIIDLDLSRYNAIASRFAEERQQTLDFLKSG...............	0	14	22	37
+6785	PF06957	COPI_C		Coatomer (COPI) alpha subunit C-terminus	Vella Briffa B	anon	Pfam-B_20121 (release 10.0)	Family	This family represents the C-terminus (approximately 500 residues) of the eukaryotic coatomer alpha subunit. Coatomer (COPI) is a large cytosolic protein complex which forms a coat around vesicles budding from the Golgi apparatus. Such coatomer-coated vesicles have been proposed to play a role in many distinct steps of intracellular transport [1]. Note that many family members also contain the Pfam:PF04053 domain.	19.70	19.70	21.30	20.60	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.43	0.70	-5.94	5	402	2009-01-15 18:05:59	2003-08-13 18:19:08	6	18	285	10	268	405	8	362.60	35	33.49	CHANGED	KGhFEGuLhohuttuAsu+tsh.lss-csA.hs.tshus-DWG.EDsD.lslDt....DuhspucDGLu-s--GE.sc-s-EEGGWDV.E-DLsLPPELDsPK.suGsA-SuhFVsPspGhuVSQpWsNsSsLAuDHlAAGSF-TAMRLLHDQLGVlNFuPaKsLFLcsYAuSRooaRAhusL.Pu..lslaPpRNWSEou.KN..usPAluaKLsQLscRLQuuYQhTTsGKFsEAVEKF+SILlSIPLlVVDoKpEVAEAcQLIsIsREYllGLpMElcRK-LPK-sL-QQKR.sELAAYFTHCcLQPVHhILsLRSAlNlFFKhKNaKTAAoFARRLLELuP+P-VApQsRKVLQACE+NsTDusQLNYDh+NPFVVCGuoYVPIYRG+P-VoCPYCGAsFsPshEGplCTVC-VApIGKDulGLRISPLQsR	.....................................................................................................................................................................................................................................h....s.........p........t....tt...p.....s..........t.tt.....s............t......t.t--...s..u..G.W..Dh.......--.......D..lpls...-.........h...ph....s.t.....................s...s.t......p.s..s.hss....sstG.......s......sp..h...Wsp.N.S.tLssDHltAGuF-oAhpL.LpcQlGllsFtPhK.hFhphatsu+ohh.uhssh.Ps....lh.s.h.pRshp..-s..s....pp.....shPslsh.plsp.Lh.p.c...Lp.t.u.Yph.hssuKhp-AlctF+sILholsll.s.Vcs...cpE..hsEsppllplsREY..llu.Lph..ElcR+p..l..s.......p.....s...sh.......c.......p..........+.....R.hE..LAAYFT+spLQssHhhLsLpsAhshhaKhKNatoA............usFAc...RLL....-.....h...........u.....s......p......s......c.....h.............A.p...p.....sRKlhs.ts.E.+..s..s..p..D..shpl.s......a..D............a......s.......s...F......slCuu.oas...P..I..Y.c......Gp.ss.......hpCPhsGupYp.s.pa+..GplCplsplsplGtss.GL+l...................................................................	1	98	152	226
+6786	PF06958	Pyocin_S		S-type Pyocin	Vella Briffa B	anon	Pfam-B_20020 (release 10.0)	Family	This family represents a conserved region approximately 180 residues long within bacterial S-type pyocins. Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity [1].	22.50	22.50	23.00	22.50	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.85	0.71	-3.82	39	258	2012-10-01 19:36:59	2003-08-14 10:59:20	7	25	167	8	54	270	1	134.20	31	24.52	CHANGED	hpphttstsslshsVRhph...pstsGph..p........lhsl+T..s.tsssspVsVhps.thsppsshap........sssssshslhaoPssss.....tssssosss........................sss.sssshsssslststsp...spshPs.ptt-hcD...hIlsFP..tsSGltPlYlh	...........................phAtstuossh.VRhph...ps.sGp...p........lhul+T..utss.shspV.Vtth.phstpostYc......hh.scs.sss.slhWTPssss.....hpssspTuss........................sss.....hsshhstslsssssp...stshPhs-.c-acD...aIlla.P..hsSGl.PlYlh.................	0	3	12	30
+6787	PF06959	RecQ5		RecQ helicase protein-like 5 (RecQ5)	Vella Briffa B	anon	Pfam-B_20083 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long within eukaryotic RecQ helicase protein-like 5 (RecQ5). The RecQ helicases have been implicated in DNA repair and recombination, and RecQ5 may have an important role in DNA metabolism [1].	25.00	25.00	26.00	26.30	19.60	23.70	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.18	0.70	-4.69	2	54	2009-01-15 18:05:59	2003-08-14 11:51:20	6	4	30	0	22	45	0	185.70	53	21.94	CHANGED	KSCuAtAE.sEPs-YDIPPsSHVYSLKPKRlGAGFsKGsCsFQTATELhtpo+.pcQAPps.htGtpEPPuhsCsL.DEDtScPhPG.ptcs.GuSsphGsPSPEKKsKuSStGS..AKuRASKKQQLLATAA+KDSQsIsRFhCpRsESPsL.ASsPcuEsAsPSCtsV......PtKhT.pEsGAtGH.sAs.QTEt..RERP	..................SCuApucssEPsEYD.IPPASpVYSLKPKRVGAGFPKGSssFQTATELhcpop..p-QAPps..psGcpEPPSpsCsL.DEDpScPLPGPp..sEsPGuSApsGsPSPEKK.......sKuSosGSslAKuRASKKQQLLAsAA+KDSQsIuRFFC.p.R.s.cS.Psh.s.SuPcA.Es.As..PS.Ct.GVpus..hsPEKho.cED.GA..tG+.sAssQTEt..REt..................................	0	1	1	6
+6789	PF06961	DUF1294		Protein of unknown function (DUF1294)	Vella Briffa B	anon	Pfam-B_3405 (release 10.0)	Family	This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.	25.00	25.00	27.20	25.50	24.50	23.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.64	0.72	-4.01	144	1488	2009-01-15 18:05:59	2003-08-14 13:39:17	8	8	1458	0	268	969	50	54.40	44	47.80	CHANGED	sllsFhlYuhDKptAp....cspW........RlsEpoLhlluLl.GGhsGAhlutphhRHKTpKttF	....NllsFhlYuhDKppAc.....+.ptW....................RlPEpsLhlhulh.GGshGAhlutphF+HKTpKhhF.........	0	88	162	221
+6790	PF06962	rRNA_methylase		Putative rRNA methylase	Vella Briffa B	anon	Pfam-B_3461 (release 10.0)	Family	This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.	20.70	20.70	20.70	21.20	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.81	0.71	-4.48	17	1285	2012-10-10 17:06:42	2003-08-14 13:50:07	7	7	1268	14	179	706	33	135.50	43	72.68	CHANGED	+VYuFDIQcpAlppTpp+lcphh...p.....lcLlhsuHEplpcal.p....sl+uulFNLGYLPuuDKpIsTpscoTlpAIpclLsllp.sGlIslVlYaGH-tGchEKcAVhpFsppLsQpcapVhpaphlNQhNsPPhllhIEK	..............pVYuFDIQcpAlcpTpp+Lcptt...h.s.....................spLlhsGHE.s.lc...p...alsc.................lcA...uIFNLGYLP.......u..u..D..Ks.....llT+.PpTT.lpAlppllpl...LshsGhIslllYaGHpsGphE+-AVLcasppL.sQppap.V.hpYphlNQhN.sPPallhIEK.......................	1	74	125	155
+6791	PF06963	FPN1		Ferroportin1 (FPN1)	Vella Briffa B	anon	Pfam-B_3588 (release 10.0)	Family	This family represents a conserved region approximately 100 residues long within eukaryotic Ferroportin1 (FPN1), a protein that may play a role in iron export from the cell [1]. This family may represent a number of transmembrane regions in Ferroportin1.	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.28	0.70	-6.10	19	342	2012-10-03 03:33:39	2003-08-14 15:26:02	7	7	156	0	257	446	7	355.50	26	83.29	CHANGED	ppslhhLYluHhLusWssRMacFussLalsplassoLLhsuVYuLVcohSslllushlGphlD+.sRl+..slRpsllhQplshslusuhhhhlhhhsp.h...............shlhhslasssslluslspLAssAsolslERDWlVVlu.st.sssLsphNushRpIDLhsclluPllsuhlhuhhShphushhlhshNlsshhlEahhlhpVYptsPtLtcppctppscsptspp...............................tt.t.phthhpphtphhcps.hssWptYhpQsVFLAuhuLuLLYhT.VLSFGshMssaLhpp.GhsshhluhhRususlsGlsGTashPhltp+lGhlRoGlaulhhQhsCLhssVsuhhhssss.................................................................stlsshhLhsGVAhSRlGLWuFDLuVppllQ-...................slsEucRshluusp.uLQslh-LLpashsIhhspPcpFthhshISausl	....................................................................t.....hla.h.uh.huth......ssRhapFuhslh.hhtl.a..s......t...sLh.sulhuhh.shshhhhushlGphlD.p..s.Rht...shph.l....................hhpphshhh.......sshhhhhh..h.h...............................th.hh..h...hhhh.hhhhusltpLsshs.tl....slpRDW.................l...........lsls....t....t........p.....tttL.st.....hNuhh+pl................D.h.splhuPhhhu..lhs...h.........u..........................h............h..shhhh.shshhShhhchhhh.tl.Yp.ss.t....Lt.ptt.t.tt.......................................................................................................hht.th..t....htth......htsa......Yhp.ps.sh.....h.....suhuhu....hLYhT..VL......u...........a.ss.hhssa....hhpp...Ghss.hluhh...huhuulhulh.uThhhshl..p.+h.G..h.l.+sGh....hu.hhhQ.....h.hLhhslh.sh...hh.s..................................................................................hh.sh..hhhh.ul.h.huR..............h.............GLW.aDLsh....tplh...Qp...................tl...tspRshhsuspsuhp.hh-lhthhh..sl.hhspPptFthhhhlSh.hV.........................................................................................	0	80	137	210
+6792	PF06964	Alpha-L-AF_C		Alpha-L-arabinofuranosidase C-terminus	Vella Briffa B	anon	Pfam-B_3625 (release 10.0)	Family	This family represents the C-terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase (EC:3.2.1.55). This catalyses the hydrolysis of nonreducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides [1].	28.50	28.50	28.70	29.00	28.30	28.20	hmmbuild  -o /dev/null --hand HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.15	0.71	-4.50	145	1287	2009-01-15 18:05:59	2003-08-14 16:17:07	7	28	613	70	462	1241	79	201.20	22	33.87	CHANGED	DEWusWh...........................tss..thhtpt.ohcDALstushLssht+puDpV+hAshAQllNlls...............................slhhpss.t.phhhsssYashphaupats.ussLssplpss................................................................................................................................................................................tstsshshl..sssAsh...spsstp....lhltllNh.s.t.tshslplslp...............................Ghps......pssptphL...suss.hpspNoh....ppsppVtPp............pt....p....ssph.shsLPsh......S	............................................................................................................................sEassh.............................ts.....thhtpt.shpsALstushLhsht+p.uD...h...VchAsh..A.Llssls....................................sllhhss..t..phhtssoYashphaupp..ts.upsLssplps.............................................................................................................................................................................................................tthpssshlsss.Ash......spcstp.....lhl...t..l.lNhssp...........shslslslp...............................Ghps......pssptphL...s...u..s..s....hpsp.Noh....ppPpp.........VtPp..............ppth.p.ht..s.sph.phplsshS...........................................	0	167	325	398
+6793	PF06965	Na_H_antiport_1		Na+/H+ antiporter 1	Vella Briffa B	anon	Pfam-B_1828 (release 10.0)	Family	This family contains a number of bacterial Na+/H+ antiporter 1 proteins. These are integral membrane proteins that catalyse the exchange of H+ for Na+ in a manner that is highly dependent on the pH [1].	19.80	19.80	20.50	20.40	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.40	0.70	-5.68	17	2392	2012-10-02 17:06:44	2003-08-14 16:48:31	7	9	1869	3	527	1704	1782	354.40	44	91.60	CHANGED	lpcFlcsEuuGGllLhhuAslAlllANS.sLupsYhuhlcs.htht...h.hsholtpWINDGLMAlFFLllGLElKREhltGpLushppshLPslAAlGGMllPALIYhhlNhssPtshpGWAIPsATDIAFALGVLuLLGpRVPsSLKlFLhuLAIlDDLGAllIIAlFYossLshssLhhAhhslhlLhsLNRhsVppLhsYlllGllLWhslhpSGVHATlAGVhluhhIPhcttpu.....................................p..pSPlc+LEHtL+PWVuFhllPlFAFANAGVSluGhsls.l.ssPlsLGlslGLhlGKslGlFhhualAl+LsLAcLPcGhsWsplhuVulLCGIGFTMSlFIupLAFss....thhs.sKlGlLhGSlhuAllGhhhL	.....................h.pcahpp-ssGGllLlhuullAhlhANS..s...........h.u.t.hY.pshh......c...h..............l......t......h....t............h......s......t........h.t......l......s...hslhh.WINDuLMAlFFhllGLElKRE..lh..p.GpLssh.cpAshPhlAAlGGMllP.....ALlYh..............h..............h..............N...h.......u..s.............s.............................s....h.pGWAIPsATDIAFA.LGlL.u.L.LG.s+lPhuLKlFLhuLAIlDDLGAIllIAlFY...T..s...s...L...u...h.hsLsl.Ahhs....ls..l.L..........h.l............L........N..........h........h........t...........l........p........p........h...hh....Y.l.ll..G.l.l.L.....WhslLcSGVHATLAGVlluhhIPhctp..p.s...........................................................................................puP.....h.c+lEHsL+PaVAalI..lP..lFAFANAGVslp.u.h...s...l.................s.sl......ss.............lsL....GIhhGLhlGKslGIhhh.saLul+ht.l...ApL.PpGhsap.plhululLsGIGFTMSlFIusLAFss........tst..h..hs.huKlGILh..GShhuAllGahhL..................................	1	161	342	452
+6794	PF06966	DUF1295		Protein of unknown function (DUF1295)	Vella Briffa B	anon	Pfam-B_3514 (release 10.0)	Family	This family contains a number of bacterial and eukaryotic proteins of unknown function that are approximately 300 residues long.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.79	0.70	-5.07	12	924	2012-10-01 22:51:20	2003-08-14 16:53:11	7	9	605	0	506	2016	1927	217.80	24	75.13	CHANGED	hallsthptpsshlDhhWusshslluhhshhh......stu.hshRphllhhLsslWulRLuhalhhR.shptG..EDhRasphRcphstt.........phhh.hahhQulhlahluLPlhlstustss......sh.tshshlGhslalhGhhhEshuDtQL.sF.................KtsPtN+G+.hhssGLWpaoRHPNYFGEhlhWWulalluhss..hpsh..hslhuPlhhThLLlaVSGlPlhEtph.+phttt.ta+pYpcpT	......................................................................................................................................ahht.h.tp....t.hh.Dhhhuh...s...s.h.hshhh.hhh.......................tts....s.hp.ph...l...l...h.hh..s...hlWuhRLsh...a.hh..h.R...h.......h....t.........s.....-D..Ra........t.....th+..p..p..hs.........................h.thhh..ha..h..hQ..u.....l.h.l..h...h..l.u...l.Ph....h..h....s.........s.........t.....ss...................sh....s..h...h.s....h.l..u..h...s..l.......a...l....h.....G..h...h....h.....E..sl...u.....D......h....Q...h...h.p.F................................................+..p.....s....s...t.....s.............c...........G...........c.....hh..........s.....s.........G.L.W.pa..oRHP....N...YFG......Eh..hh..W...h....u...l......h..l.h.u..h....s.s...................ht......s..........h.........................h..s..l...........h....u...P.l.....h.....h.hh.l...L.h..hh..o...G.hsh.hEp....h..c.ph...............s..tYppYppps..................................................	1	210	340	440
+6795	PF06967	Mo-nitro_C		Mo-dependent nitrogenase C-terminus	Vella Briffa B	anon	Pfam-B_6998 (release 10.0)	Family	This family represents the C-terminus (approximately 80 residues) of a number of bacterial Mo-dependent nitrogenases. These are involved in nitrogen fixation in cyanobacteria [1]. Note that many family members are hypothetical proteins.	19.30	19.30	20.30	47.80	16.70	15.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.92	0.72	-3.83	13	139	2009-01-15 18:05:59	2003-08-14 17:19:46	6	5	53	0	56	140	8	83.00	57	56.74	CHANGED	-lLpPlRpWLDulcIpst+lAHhlC+LIPsQCPFERDlsLFGRhlhHIPPLCKLNPLYEplVuLRFRALsYLADECGEDIopYs	........lLpPlRpWLDsl-lcssclA+h..lC+lIPuQCPFERDIpLFG+plhHIPPLCKLNPLY-plVuLRFRALsYLAD-CGEDlotYh........	0	5	41	56
+6796	PF06968	BATS		Biotin and Thiamin Synthesis associated domain	Finn RD	anon	Pfam-B_5417 (release 10.0)	Domain	Biotin synthase (BioB), EC:2.8.1.6 , catalyses the last step of the biotin biosynthetic pathway.  The reaction consists in the introduction of a sulphur atom into dethiobiotin. BioB functions as a homodimer [1].  Thiamin synthesis if a complex process involving at least six gene products (ThiFSGH, ThiI and ThiJ). Two of the proteins required for the biosynthesis of the thiazole moiety of thiamine (vitamin B(1)) are ThiG and ThiH (this family) and form a heterodimer[2].  Both of these reactions are thought of involve the binding of co-factors, and both function as dimers [1,2]. This domain therefore may be involved in co-factor binding or dimerisation (Finn, RD personal observation).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.92	0.72	-4.14	127	5028	2009-01-15 18:05:59	2003-08-15 13:00:51	8	10	3397	6	1177	3436	382	97.40	30	26.94	CHANGED	slNh..LpPh.pG......os.h.........ts.....t.lssp-hl+hlAhhRlhhPp.stlpluuG+pthhcc.h.s...lshhuuusuhhsGsY..........................hssss.cshscshphlpchG.h......ps	...................PINh....Lhss.pG.....Tsh............ts..spsls.sh-hl+hlA.shR.lhhPp.s.tlRlSuGR.p.hh.cp..hts.....hshhu.uuNu...l...h...hGsh........................................................................Lhosspps.cpDhphlpchGhp................................................................	0	421	778	1014
+6797	PF06969	HemN_C		HemN C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_833 (release 10.0)	Domain	Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX [1], one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparison to other proteins containing a radical SAM domain (Pfam:PF04055) suggest it may be a substrate binding domain.	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.95	0.72	-3.91	87	5381	2012-10-04 14:01:12	2003-08-15 13:44:13	11	4	3710	1	1096	3872	632	66.00	23	16.25	CHANGED	lstp-thpEhlhhsLRh..ptGlshpphppphs.t.....h.t.h.tthlpphtpp..GLl....phss..stlplTppGhh	..........................stc-phcE.hhhsLRh..ppulshsphp.ppa.Ghs..........htphh...tp....lp...p...hhpp......GLl...............p.h.s.s.....stlplTpcGhh.............................	0	314	660	891
+6798	PF06970	RepA_N		Replication initiator protein A (RepA) N-terminus	Vella Briffa B	anon	Pfam-B_1808 (release 10.0)	Family	This of family of predicted proteins represents the N-terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids [1]. Most proteins in this family are bacterial, but archaeal and eukaryotic members are also included [2].	30.00	30.00	32.70	31.90	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.60	0.72	-4.19	55	1268	2012-10-04 14:01:12	2003-08-15 15:21:35	6	6	685	0	75	856	25	73.30	38	29.74	CHANGED	ppFaplPKsLhpsppY.cpLSs-AKlhYulLhDRhpLSl........+Ns....WlDcc.GplYhlaosc-Ltp..hLssuc.pKll+lKKEL	..................paaplPK.hLhp.s............pp.a..cplSs-AKlhYulLhDRhpLSh............+Ns......W..lDc-..GplYlla.ospcLhc..hLsp.uc.pKlh+lhcEL.............	0	29	43	58
+6799	PF06971	Put_DNA-bind_N	Put_DNA-bind_C; 	Putative DNA-binding protein N-terminus	Vella Briffa B	anon	Pfam-B_3389 (release 10.0)	Family	This family represents the N-terminus (approximately 50 residues) of a number of putative bacterial DNA-binding proteins.	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.25	0.72	-4.20	17	1817	2012-10-04 14:01:12	2003-08-15 15:45:00	8	3	1640	24	349	1010	155	49.40	47	22.82	CHANGED	ppIPcAshKRLPhYaRhLctLhppslcRlSScpLu-tlslsuupIR+DFS	........pIP.c.A.ThKRLPlYYRhlppLps..pG.l.c+lSSpplu-AltlcSAoIRRDFS.	0	159	268	317
+6800	PF06972	DUF1296		Protein of unknown function (DUF1296)	Vella Briffa B, Eberhardt R	anon	Pfam-B_4035 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long within a number of plant proteins of unknown function. Structural modelling suggests this domain may bind nucleic acids [1].	21.60	21.60	21.70	26.00	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.06	0.72	-4.01	7	106	2012-10-01 23:03:33	2003-08-15 16:05:18	6	3	19	0	70	100	0	57.30	55	7.87	CHANGED	lPsth+phlQsl+ElVss..S-t-IauhL+EssMDPsEssp+LLpQDsFHEVKSKR-KKKE	....lPsusRKhlQulKEIVss.ho-t-IYAsL+ECsMDPNEssp+LLsQ.D.sFHEVKpKR-KKKE...........	0	13	40	54
+6801	PF06973	DUF1297		Domain of unknown function (DUF1297)	Vella Briffa B	anon	Pfam-B_3819 (release 10.0)	Domain	This family represents the C-terminus (approximately 200 residues) of a number of archaeal proteins of unknown function. One member is annotated as being a possible carboligase enzyme.	23.80	23.80	24.90	31.30	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.09	0.71	-4.98	40	191	2012-10-10 13:17:03	2003-08-15 16:23:52	7	2	111	19	120	188	129	185.00	43	52.81	CHANGED	EapcKhcplhcpGlIspcslcpspIEEYllGshashpaFYSPlpcc........l...EllGlDpRhEoNlDGhhRlPAppQl.ch....slpPpallsGphPsslRESLL.pVF-hG-+aVcAo+clhsPGlIGPFsLQoll...sc-...L-hlVF-lSsRIsGGTNlahs.GSPYStLhascshShGRRIA.......hEI+pAlcpscL-cllT	...............-a.cKhpphhcpGllppcslppshIpEYllGs.h.hpaFYSPlpsc.................l...ElhGhDpRaEoslDGlhR.lPAppQl.cl....plpPpallsGphPsslRESLL.cla-hG-+aVcuscclhs..P.GlIGPFsLpoll......sccL-llVF-lSsRIsuGTNhahs.GSPYShLhascPhShGRRIA.......hEI+pAlcpspL-cllT..............	0	30	60	89
+6802	PF06974	DUF1298		Protein of unknown function (DUF1298)	Vella Briffa B	anon	Pfam-B_4362 (release 10.0)	Family	This family represents the C-terminus (approximately 170 residues) of a number of hypothetical plant proteins of unknown function.	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.68	0.71	-4.42	14	691	2009-01-15 18:05:59	2003-08-15 16:32:11	8	13	255	0	271	581	59	145.90	22	32.32	CHANGED	KsSKCR..WGNahGhlllPFsl.uLcsDPL-Yl+pAKuhhDRKKpShEAhhoYhhh+hllKhFGhKsusslhpRhhsNTThsaSNllGPsEEISFhGHPIsYlAsSsYGpPpALsIHa.SYssKhhIsluVDsslIPDPH+LCDDhEESL+hhKsA	............................................................................s.........GN.hu..h..h..h..h..s.h......h....t......s...sP....l.phlpt.......h..p..t..th...p...t......t.+...p.....p...h...p......t......h.........h...h..........h.....t....h...h....h....h..h...h...u.......t...h...h....t....t...l.....h....t...t...h...............s......h........s.l..s...lSNV.PGPp-.....lhhsG.u......l..s..t..h.hs...s.s.h.s..t.s.p...........u....L..sl..olh..SYssp.lshulhssp..ssls...-spclssthtcuhppl....................	1	71	176	236
+6803	PF06975	DUF1299		Protein of unknown function (DUF1299)	Vella Briffa B	anon	Pfam-B_3488 (release 10.0)	Family	This family represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that many family members contain multiple copies of this region.	25.00	25.00	45.20	45.20	19.90	17.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.39	0.72	-4.10	4	21	2009-01-15 18:05:59	2003-08-15 16:40:27	6	4	1	0	0	21	0	46.50	84	17.30	CHANGED	HDEas-stDQEAYlILSDDEsNGTAPTEKESQPpKEETTEVPKEEsV	HDEHDETEDQEAYVILSDDEDNGTAPTEKESQPQKEETTEVP+Epph	0	0	0	0
+6805	PF06977	SdiA-regulated		SdiA-regulated	Vella Briffa B	anon	Pfam-B_2520 (release 10.0)	Family	This family represents a conserved region approximately within a number of hypothetical bacterial proteins that may be regulated by SdiA, a member of the LuxR family of transcriptional regulators [1]. Some family members contain the Pfam:PF01436 repeat.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.59	0.70	-5.43	24	899	2012-10-05 17:30:42	2003-08-15 17:25:23	6	9	524	1	91	519	74	223.90	40	78.35	CHANGED	stulhLssY+ssl-.u+slsGlccs.lSuLTYsPppcoLFuVsNp.sspLlELShcG-lLR+lPLtG.FsDsEulpalusGphslsDERpppLhhlplsspTpslshs-...hpphsLGhs..tssNKGFEGlAaDstspRLhluKERsPhtlaclpu.......ss.sltsssptsh.t..pplhl+D...LSuLpaDtpoGHLLlLSDESRhllElD.tpGc.lShhoLhtGhsGLccslPQAEGlAhDccGsLYlVSE.PNLFYhFc	..............................................................................................................................................................................p.sh.hpsYcssls.tK.lsGlps.s.lSuLTass....pspp.LFushNp..P.........u..........t..l..V..ch....o.p.p.G.c.l........l.+p.hP.L........sh........h.........p........DhEsIEa.l.GsN.p...as.l.u.....-..ER..c.......h.....t..lhhhpl......................o.......t..s..p..l...t.......hh.cl.p.lshp....pspNpGFEGLAastpscpha.h.h......K..E...+.....pP.....lp....lhcspt.................................ssspLphucstslp........tthplp.D.......l......SGhp..a..s.tp.pspLllL.ScES+hl..hEls..pGc.hls.....hsLs+G..p..GLpc..sI.Q.uEGIAhD.s.p.s.slYIVS.E.PN.hFY+Fo..........................................................	0	20	42	75
+6806	PF06978	POP1		Ribonucleases P/MRP protein subunit POP1	Vella Briffa B	anon	Pfam-B_7848 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5) [1]. These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.	22.20	22.20	24.00	24.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.44	0.71	-4.63	38	354	2009-01-15 18:05:59	2003-08-18 13:52:12	6	10	265	0	265	358	4	151.60	31	21.10	CHANGED	FlpuRphEIcslppuhppuKtstsoRsFQplPRpLRRRsASHNl+RlP+RLRsRAt+EMhpsss.....................ttphhh+hcst++l.ph.tp...............................................................................................ltp.s.spt+ap+RQcp......p..pWL.THlWHAKRh+Msc...............hWGaplPh..sPTpKsaRssaR.....tspcsslsaDhSYhss....ltlpGs	...............................................................................................................................................................................................................................................FhtuRthElpth.tuhpppp................sp..hsF.Qp..lPRphRRRshSHNs+RlP+.RhRthshpch.pstt.......................................h.p.c.ttt.................................................................................................................................................................................ht...p....ca..t+Rp.pp........p....hWL.THlWHAKRh+Mhc...............hWGatls...ps..stKsaRssaR..................t.pptslh.DhSYhssltlps.t.....................................................................................................................................	0	104	157	222
+6807	PF06979	DUF1301		Protein of unknown function (DUF1301)	Vella Briffa B	anon	Pfam-B_8295 (release 10.0)	Family	This family contains a number of eukaryotic proteins of unknown function that are approximately 160 residues long.	21.70	21.70	23.90	23.70	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.76	0.71	-4.01	7	128	2009-01-15 18:05:59	2003-08-18 14:35:39	7	4	104	0	91	127	1	128.50	34	59.20	CHANGED	uVKhFShSTSlsulsh.P.lLLcpuhthsu..hshtlhhhGlhGFFTFlTPlLLHhlTKtYVhcLaa-ssp-pYTAsThshhLpcppThF+.cDVslP-lsthFToFhscsKuLhVsPsLFPsPpcY.+lMGYDK	.......................................VKhFShSTShhulshhPhl...hhpss..ths.u....lsh..p.shhsuh.luhFohh...TPhlLH.alT..KsYVh+L..aa.p...ss............o.D..........oYpAhThs.hlhpcppp...........sF+.sDV....p....lP.-.....ss.+hF...TTFhAcs+shhVssthF.ss.pca.+lMGY-............................	1	28	43	70
+6808	PF06980	DUF1302		Protein of unknown function (DUF1302)	Vella Briffa B	anon	Pfam-B_7023 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.	19.90	19.90	20.70	20.10	19.50	19.70	hmmbuild  --amino -o /dev/null HMM SEED	554	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.66	0.70	-5.94	64	345	2012-10-03 17:14:37	2003-08-18 15:53:48	6	3	208	0	139	351	210	566.70	31	94.05	CHANGED	hsFshG.-...lpssaDoolShGsuhRspstspshh...........................................tssstssssDDGsLNac+.G-shSphlKuhp-LpL+assh.......GhFlRGphaYDhthp-sstp....................................s.ss.pscpttspsscLLDAaVatsasl..GcpP.sslRlGcQVlsWGEShF...ltsG...I.NshNPlDls.thptPGuElKEsllPsshl.suhuLocsLSlEuaYQ..acWcpotlsssGTaFSssD.hhucGsps..h............................h.hhss.ss.sh...............................shhh.css-tcuccsGQaGlslRahsttL..-TEaGhYahNYHs+hPhlussssshsshs......................................................................spYhhpY.sEDIcLaGhSFsTslG......ssuluGElSYRsstPl.tlsssplh...........huuhssts...................................shss...Gt.hp.......G...Ytct-shQhploslphhst..........shGAspholluEluhsalhul...ststhphs.t.ssht..............................................t..tstspshsTpsuaGY+lthphsYsslas.GlsLsPslsauHDlpG..hoPs...sssF.sEGp+ululGlshsYp...spapsslsYssFaG.............Gshs......................shsDRDaluholshoF	............................................................................pFshG..-...lpupaDoolohGsuhRspstspsll................................ststs.stssDDGslNFc+..G-shSphhKulp-LcLpatsh.......GhFlRGphaYDhthpDpspp.....................................hhs...s.ss.ppct.hpupsscLLDAFVatsasl..GstP.hslRlGcQVlsWGEShF...hts...G...I.suhNPlDls...thptPG.uEl.KEsl.................lPlshl.huhsLT-sLSlE...uaYQ..hcWcpohlsssGTaFSssD.....hh.u.cGspthhh................................................hss..tt......................................shhh.c..us-p.cscc..u..GQaGlsl+ahsptL..-TEaGhYahNYHu+..tPh...luspsushsshs..s..................t................................................................spahhpY.PED.I+LaGhSFsT..s..lu......ss.uluGElSYR.stPl.tlssspll...............hushssts...........t........................ss.s.........GtthpGahRt-shQhphohh.phas...........shGA-pholluEluhs+ltsl...shsphphs..tsss.ht........s..s........................................shsp..tspssshsTpsuaGYclthphsYssVas.GlslpPslsau+DlpG.hoPs.....h.ssF...tEGpKulolGlshsYp...spapsslsYssFaG.......uphs...................................shsDRDaluhohphsF................................	0	33	60	105
+6811	PF06983	3-dmu-9_3-mt		3-demethylubiquinone-9 3-methyltransferase	Vella Briffa B	anon	Pfam-B_6583 (release 10.0)	Family	This family represents a conserved region approximately 100 residues long within a number of bacterial and archaeal 3-demethylubiquinone-9 3-methyltransferases (EC:2.1.1.64). Note that some family members contain more than one copy of this region, and that many members are hypothetical proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.46	0.71	-3.75	25	2984	2012-10-02 15:00:03	2003-08-18 16:55:30	8	7	1713	10	686	1992	166	128.00	27	87.56	CHANGED	sKIossLWF...D.spAEEAspFYsSlFsNScltslschspst.su.....tGsVhsspFslsGpsFhuLNGG..PpFpFscAlSFhlsCcsQcElD+hWstLstsGu........ppu.tCGWl+D+aGlSWQll	..........................................................sPaLhF....s....up...ucEAhsaYpp.....s.F.............s........s........u.....p..l.....h.....p.h.......p........p....h......s....p......s.....t.....st................ps.....p.....l...h.....au.....p......h......p.l..s.G.p...s...h..h....s............D.......u..s............s.s...h.....p.......h..........s.......s....u.......h.....S.......l....h...l..s..............s.........c..........s..p.....p.....E......s....c......c...h...aspLsssGpl.h.............pthhts.taG.hlpD+FGlsW.l..........................	0	219	460	593
+6812	PF06984	MRP-L47		Mitochondrial 39-S ribosomal protein L47 (MRP-L47)	Vella Briffa B	anon	Pfam-B_6890 (release 10.0)	Family	This family represents the N-terminal region (approximately 8 residues) of the eukaryotic mitochondrial 39-S ribosomal protein L47 (MRP-L47). Mitochondrial ribosomal proteins (MRPs) are the counterparts of the cytoplasmic ribosomal proteins, in that they fulfil similar functions in protein biosynthesis. However, they are distinct in number, features and primary structure [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.02	0.72	-4.08	8	327	2012-10-02 11:59:50	2003-08-18 17:11:16	8	5	288	0	229	380	11	87.70	41	34.85	CHANGED	LhEFF-s.....c+sh..sEpc.s.KsG...+uWssppLRpKShsDLHpLWYshLKE+NMLhThcpchpcpphs...hPuPERlcKV+pSMcslcpVlpER	.....................................L.pFFss.............pps.h....s.p..p.c...sp.tG.......RuWss.pELRtKSh-DLHpLWaVhLKE.RNhLhTh...cpctp...+ppht..............hss.s-.R.h....c.+...Vc.........poMppIcpVlpER......................	0	77	126	190
+6813	PF06985	HET		Heterokaryon incompatibility protein (HET)	Vella Briffa B	anon	Pfam-B_8200 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins that seem to be restricted to ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two different wild-type strains [1]. Many family members also contain the Pfam:PF00400 repeat and the  Pfam:PF05729 domain.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.32	0.71	-4.02	164	2623	2009-09-13 05:28:11	2003-08-19 10:54:52	6	149	90	0	2311	2726	2	139.30	21	21.73	CHANGED	YtsLSYsW....Gsst.........................tttl......................hplsps.lpsAlphs.+.p.........h.....uh.cY.....lWlDslCIsQ....s.ss......-hspplspMtplYppAthslshhusss.............................pt.....................h.shp.h.....pthtt.tht.............................................................................t..hhpp....ltp......s.WasRuWslQE	.....................................................................YhsLSasW.........Gssp................................................................................p...t.h...h..t...........................h.t.l...s...p....s.......l.p.s.Alphh...+.p...............h..............sh..ca..............................lWlDs......l...C.I....s.Q................s....st.............t.......-.........hs.ppls.t...M.tp..lYpp......Athsls.hhu..sss................................................................s..tt...................hh.p...............t..............................................................................................................................................t............h..p.......t..h..h....pRhWshQE.................................................................................................................	1	357	1215	1922
+6814	PF06986	TraN		Type-1V conjugative transfer system mating pair stabilisation	Vella Briffa B	anon	Pfam-B_8400 (release 10.0)	Family	TraN is a large cysteine-rich outer membrane protein involved in the mating-pair stabilisation (adhesin) component of the F-type conjugative plasmid transfer system. TraN is believed to interact with the core type IV secretion system apparatus through the TraV protein [1][2][3].	21.60	17.10	23.00	17.90	20.30	16.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.24	0.70	-5.02	17	647	2009-01-15 18:05:59	2003-08-19 13:20:02	6	8	342	0	93	486	42	199.50	26	41.21	CHANGED	stCphspc.pCh...Essts+h..lsGlsl...........sh..sCWctptsYpCss...............................ss..TCstlpsp.......sCphspppCh.p...pptuhChptphsapC.pps..ssss...phhCusssaClsGsChpsppctss..-FscusutLuAlspAsp-hsss..........shplFpGputpCp+thhG.hssCCss.pGaG......slu...............ltp...CsstEcsLuptcppshsh.lGoYC..ucK..llusChp+KcsYCsFpSKLu+llQpQG+p.QLGhuaGosKpssCpu............lTs	.........................................................................h.................................h...............................th.....Ch.t..p..p..h.s.......................................s..sCt.h.tp.......tCt..h..p.ppCh.................tttu.Chh...hYp...Ct.p..............tt........p......t.....s.ss..t..t.....t.............pt..thtp.hs.hthh.t.ht...thts.................h.hFtGp...........C..p.h.....h..h.s....h........sCCpp..tsh.s.........t........................................................................lht.....CsppEhtlsttc.tt....ph.sh.lGpaC.sp+.....hlu...sCl.pc..+cs.aCpFpSpLupIlppps+......Q....L....t....h.....s....aGss.p....ps....pCpuho.s.................................................................................	0	21	47	72
+6816	PF06988	NifT		NifT/FixU protein	Moxon SJ	anon	Pfam-B_5696 (release 10.0)	Family	This family consists of several NifT and FixU bacterial proteins. The function of NifT is unknown although it is thought that the protein may be involved in biosynthesis of the FeMo cofactor of nitrogenase although perturbation of nifT expression in K. pneumoniae has only a limited effect on nitrogen fixation [1].	20.80	20.80	20.90	21.90	19.80	17.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.03	0.72	-4.50	36	178	2009-01-15 18:05:59	2003-08-19 13:33:27	6	3	167	1	86	157	12	63.60	47	82.34	CHANGED	M.KVMlRcssp.ssLssYVPKKDLEEslVsh-..pschWGGhlsLuNGW..pLtlPshsssspLPlTV-A	M.KVMlR+sss..sLosYVPKKDLEEslVp.hE..psshWGGhlpLuNGW..pLtlPphsscspLPlTl-A...	1	22	52	68
+6817	PF06989	BAALC_N		BAALC N-terminus	Moxon SJ	anon	Pfam-B_5793 (release 10.0)	Family	This family represents the N-terminal region of the mammalian BAALC proteins.\	 BAALC (brain and acute leukaemia, cytoplasmic), that is highly conserved among mammals but evidently absent from lower organisms. Two isoforms are specifically expressed in neuroectoderm-derived tissues, but not in tumours or cancer cell lines of non-neural tissue origin. It has been shown that blasts from a subset of patients with acute leukaemia greatly overexpress eight different BAALC transcripts, resulting in five protein isoforms.  Among patients with acute myeloid leukaemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukaemia. It has been suggested that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions [1].	25.00	25.00	51.00	51.00	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.52	0.72	-3.64	2	32	2009-01-15 18:05:59	2003-08-19 13:40:07	7	1	21	0	15	28	0	51.80	76	40.27	CHANGED	MGCGGSRADAIEPRYYESWTRETESTWLTYTDSDA.PSsAAsDSGPEAGGLpA	MGCGGSRADA.IEPRYYESWTRETESTWLThTDSDuP..PSu.A..As.........DSGsEAGG.................	0	1	3	7
+6818	PF06990	Gal-3-0_sulfotr		Galactose-3-O-sulfotransferase 	Moxon SJ	anon	Pfam-B_6301 (release 10.0)	Family	This family consists of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans [1].	20.20	20.20	20.20	20.30	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.61	0.70	-5.81	3	598	2012-10-05 12:31:09	2003-08-19 13:49:40	6	17	61	0	434	689	22	279.80	24	77.98	CHANGED	MhPhLttLQ+ts+hhht+tLlLslLhhooFLLLlaphA..shHucLt.sTP.FuuSCsP.t..............EuPPRsN...IsFLKTHKTASSTVLNILFRFAE+HNLoVALP.sGsRscFsYPphFuA+aVc.....ussupp.FNIlCNHLRFchsEVc+LMPssTlYlTILR-PAthFESSFpYYssYsPAFR+lPuus.L-AFLpuP-sYYcsucH.pAhYA+NsLaFDLGhDN-hsPps-puYVpu+ItEVERRF+LVLIAEYFDESLVLLRRLLsW-LDDVLYFKLNARuASsVuRLSuEstu...RARoWNALDu+LY-HFNATFWR+V.AchGRcRlcREVccLRcARcRLtolClsDGsAL+sAAQIRDcpLQPWQPSGKsDILGYNL+sGluspssplCpRLlMPElQYhscLhApQ	.............................................................................................................................................................................................................................................................................................................................................................................s....h..pp.........lhFl..KoH.KouooT..l..sl....l.h.R..............au..p..cpL.ph..s.........hP.....t.......t.........t..h....t.a.......P............h..t..t.p....h...l..........................t.............as...l....h.s.p......H..h..........c.......a..p..........h...t..t...l.t.pl.h....s.s..s....s...h...........a.hoIl....Rc.Ph.t........hcS.F..t..a..a.........t............................................h...........h....h............t........h..................s.......................ltt....F..l..p.....p..P.............t....a....h......p..............t......t.....................t...........h.........h........h...+......N.......h.....h....a....D.h.G...............................................t........t.............t................h.p......t...h.lt.tlp.p....tFpLVhlhEaa-ESl..lLL+chhs...W......phcDll........h...h....t.......h....s...................p....t............t...p..............................t.......h..s........t...t..................ph..p...tas.h...Dhh...LYpaFNt.........ohWp+l...tt......G...t......h.tpht....hpth.tt..h..t.C.......................................................................................................................................................................	0	290	302	342
+6819	PF06991	Prp19_bind	MFAP1_C;	Splicing factor, Prp19-binding domain	Vella Briffa B	anon	Pfam-B_8343 (release 10.0)	Family	This family represents the C-terminus (approximately 300 residues) of proteins that are involved as binding partners for Prp19 as part of the nuclear pore complex.\	   The family in Drosophila is necessary for pre-mRNA splicing, and the human protein has been found in purifications of the spliceosome. In the past this family was thought, erroneously, to be associated with microfibrillin.	20.90	20.90	21.50	21.30	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.94	0.70	-5.12	5	330	2009-01-15 18:05:59	2003-08-19 13:57:47	6	8	269	\N	245	315	2	231.40	35	59.81	CHANGED	EtElhptE-EccupEEEEE.ESEpEE-TDSEDDME.....PRLKPlFlRK+DRs...TlQE.+E+EttKpctL.EtEAKRtAEERK+pTtKIVEEslKKELEtcKs......p.cAsls..sV-TDDE.N-ppEYEAWKLRELKRlKRDREEREshEREKtEIE+hRNMTEEERRspLRpNPKVlTNKssKGKYKFLQKYYHRGAFFh.DE--E........VhKRDFSpATtED+FDKTILPKVMQVKN..FGRuGRTKYTHLV-EDTTcasSsWsusss.NpKF...s++AGGhRssF-+PsuKKR	..........................................................tct.p...p..tp..p.p.-p...psp..E..p.......o..-sE--...................hl.+P.lFl.pKppR.............o.htp...ppt.t.........c..p...pp.h...c.t..p....t....c...c.h....h.cp..R..+...p.s.p.....llc-ph.c+-httppt................t.........ss........hp......sss.T.Ds....ssc........t.........EYpAWKlRELcR...l.KR-R-..t.......h.-..th-+E+tElERhRshT-..EERpt.......-.......c..t..t..s.c..............p..p.c...t.....KG...Kh.....tFh.QKYaH+..GAFa...Dp.tc.p..........l.h+R..D...hs.s.s.p.h.-Dp.h.s+phLPchhQV+s...hG+pGR.T.KYpcLhspDTs.....pa..s......s.....h........................................................................................	1	81	132	197
+6820	PF06992	Phage_lambda_P		Replication protein P	Moxon SJ	anon	Pfam-B_6611 (release 10.0)	Family	This family consists of several Bacteriophage lambda replication protein P like proteins. The bacteriophage lambda P protein promoters replication of the phage chromosome by recruiting a key component of the cellular replication machinery to the viral origin. Specifically, P protein delivers one or more molecules of Escherichia coli DnaB helicase to a nucleoprotein structure formed by the lambda O initiator at the lambda replication origin [1]. 	21.10	21.10	21.10	21.50	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.42	0.70	-5.08	2	541	2009-01-15 18:05:59	2003-08-19 13:59:08	6	2	340	0	27	376	18	200.50	54	94.62	CHANGED	MKNIAAQMVNFDREQMRRIsNNMPEQYDEKPQVQQVAQIINGVFSQLLATFPASLANRDQNElNEIRRQWVLAFRENGIToMEQVNAGMRVARRQNRPFLPSPGQFVAWCREEASVhAGLPNVSELVDMVYEYCRKRGLYPDAESYPWKSNAHYWLVTNLYQNMRANALTDAELRRKAADELspMTARINRGEsIPEPVKQLPVMGGRPLNRsQALAKIAEIKAKFGLKGASV	....................................MKNIAAQMlNFDpEQMRRIANshPEQY.D-.+s...QV..p.Q.V....A..p.IINuVFSQLhAsFPA.S.l..AN..R-.QsE.l.NE..l..RRQWVLAFpENGITTMEQVsAGMRVA..RRQ..sRPFLPSPGQFVAWC+E-Au.V.hsGLPsluELlDMlaE...YCR+RG...L...Y.P.Du.E.sYPW..........+S.NA.aYWLVTNLYp.sMRAsuLTDuELRR+AuDELspMss.RIsRG...EsI.P.EPV.KQLP.shu.s.RPl..spsp.AL.u+IAEl+AKhGLKGu.........................................................................................................	0	3	8	15
+6821	PF06993	DUF1304		Protein of unknown function (DUF1304)	Moxon SJ	anon	Pfam-B_7246 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	23.80	23.80	25.20	25.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.63	0.71	-4.36	73	1298	2012-10-01 21:33:42	2003-08-19 14:01:57	7	7	1246	0	231	804	18	108.50	39	89.68	CHANGED	ssLVAl.hHlYIhhLEhFhaspstst+.sFshs..-hhptsps..LutNQGlYNGFLAsGLlhGlhhsss......shtlhhhhLhsVllAulaGuhTu.s+.+I........hhlQulPAllALlhlhl	..................hlVAl.EHhYIhhLEhhthsS..ct.ss+.sF.shsh.-phpppslp.LhtNQGlYNGhLulhL...lau...l..ahups..........hplshhhllhllsAAlYGul.Tu..s+..pI..........lhpQGh.sAlLALlull................................	0	65	139	189
+6822	PF06994	Involucrin2		Involucrin	Vella Briffa B	anon	Pfam-B_8443 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialised protective barrier) of stratified squamous epithelia [1]. Members of this family seem to be restricted to mammals.	20.90	20.90	25.30	20.90	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.13	0.72	-4.00	38	508	2009-01-15 18:05:59	2003-08-19 14:22:41	6	23	16	0	38	498	0	41.10	53	104.60	CHANGED	Q-..spE.ELHLG+QQp.......csQE.....E..LaLGc..p.pQcspE.ELH..LGc	....................QE..s.EPELpLGKQQp......Qcs..E....PE..LpLGK..QQQQEspEPELpLsc.....	0	0	0	0
+6823	PF06995	Phage_P2_GpU		Phage P2 GpU	Moxon SJ	anon	Pfam-B_7670 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 130 residues in length which seem to be related to the bacteriophage P2 GpU protein (Swiss:O64315) which is thought to be involved in tail assembly [1].	25.00	25.00	25.00	25.00	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.26	0.71	-4.72	55	1047	2009-01-15 18:05:59	2003-08-19 14:26:17	6	5	735	0	148	714	14	118.70	37	69.33	CHANGED	G.FhFsl.pTssapphpRptsaRasspsRlGt+PuhQalGsup-pIoLsGllaPchpG........GthsLptL+thAspGpshsLlpG...sG.pl.hGhaVIpsls-TpohahssGssR+l-FolsLc+hs-s	..............................GhaVFtl...pT...lsa..QplppppsaRassssRlsc+..su.hQalGssp-pIsLuGlL..hP.El.s.G...........G.choLp.tLcphAc.pG.+u.asLl...-.....G.....sG...pI...aG..h..aVIpslspTp.opFhtsGts++I-FoLoLcRsD-................	0	28	71	113
+6824	PF06996	DUF1305		Protein of unknown function (DUF1305)	Moxon SJ	anon	Pfam-B_9388 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 300 residues in length. The function of this family is unknown although one member (Swiss:Q93IT4) from Salmonella enterica is thought to be involved in virulence [1].	20.30	20.30	20.60	20.30	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.71	0.70	-5.39	121	1497	2009-09-11 01:13:09	2003-08-19 14:44:15	6	5	955	0	274	1048	48	297.70	28	87.63	CHANGED	h...tpstpa...sFaphl+.ll-..............p..htspt....s......hG....psttstp-slRhpspsuLuFssu-l...ssl.....................tt..psss....hp..lpsshhGLhGssu..PLP.haaoEhl..hpR.............ppp-sshtsFlDlFpHRhhsLaYRuWpchphs.sshcp..ss.........s.......-tasphLhuLsG.......hu...t...........htt.............................................ptshs......sst.hLtauGhlsppsRospuLp....slLsphFs..ssVplcpahspWlplstsppspLG............tt...sspLGtsshlGpclhDtpu+hclpluPlshppatpaLP...........sG.p.....thtp.....LtpllchalGtphsa-lpLhlptcplssspL..Gsst......pLGhsuaLup	..........................................................................................t..pshpasFaphhc.hLc................p....htstp...............hu..tttpstp-tlRhpsssuluFsss-ltsl.................................................tp...pssst.........hclpstahGLhGspuPLP..ha.YhEhl..hp+.............tcpcsshtsFhDlFsHRhhshha+sWpchp.hh.hsacp....ss............p..................-tauthlhuLsG.......ls..tp......pt.....................................................ch.sls........ppt...hLuauuhLspt..sR..oscslp....slluphF......s...sslpl..ppahh+hlslssspp..spLG............tt...sshL.GtssllGpplhDhps+hplplssLshppahpFLP................sG.p........ph.s..Ltthlchals.phsa-lpL.tl.t..pp..ss.s.hpL..........Gssp................pLGaouaLG..........................	0	44	112	192
+6826	PF06998	DUF1307		Protein of unknown function (DUF1307)	Moxon SJ	anon	Pfam-B_10058 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. Some family members are described as putative lipoproteins but the function of the family is unknown.	21.70	21.70	21.70	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.56	0.71	-4.08	14	1049	2009-01-15 18:05:59	2003-08-19 15:49:10	6	3	820	1	25	350	1	121.10	40	78.69	CHANGED	EocTY..pus.hsGh.clplTYoY.KG.DcVlKQoscsplpYssLGlspcEt.....A.....cchlps.scpYpslcGlp.clcYpDctshEplslDYpKsDhccl.ppLsGht.s...s.csuKsIShccotchLcppGaKc	...................................................................EoKpa...sus.ls.Gp.-ltlT..YsY..KG.DKVLKQoocspIp.Y..ssl.G.ssscEp........A...........tKhLc.s..l...us...p.Y.KsI..tG..VccKlsYp.Ds..h..A..E.plsIDhpKlDhcsL......ptluGh...phs.......s..cssK..sI....SMtph.ppllctsGaKE..........................	0	7	9	18
+6827	PF06999	Suc_Fer-like		Sucrase/ferredoxin-like	Vella Briffa B	anon	Pfam-B_8856 (release 10.0)	Family	This family contains a number of bacterial and eukaryotic proteins approximately 400 residues long that resemble ferredoxin and appear to have sucrolytic activity [1].	29.50	29.50	29.50	29.70	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.82	0.70	-4.34	28	603	2009-09-13 18:23:08	2003-08-19 16:01:51	7	12	371	0	360	589	30	219.30	22	64.87	CHANGED	sLhGTupshppalllpp.........stsWsp..pt..tt.......slhpt......lsshlppptpshthth.lshpsscps................tspssp................................lllhsthlhht.....hcthpp-hltslLshshs.......................t...th..httspc..ps.hlhVCoHusRD+pCulhG.slhpchcpphsspsh.p...................................Vh.sSHlGGH+FAssllla..................spGhaaG+lsPcplssllcp....hscsphlhchhRGht	.......................................................................................................................L.Gssts.htpal.lltp...........tsWsp....chhptp..........th.tt........................lt.t.h.hp.t..t.h.t...t.h..t.........t.h...hhh...psst.....................................................t.t.p...sp...............................................................................................................shlhsthhhh..h..........htt.h....p.h.h..p.t.hls..hsht.............................................................................t.............t.stt...psshlLlCoHup....R..D....t+..CGl.t.G.s..ltpphpcpltt....t....sh...........................................................................................lh.sSHlG...GH+aAuNllla................................................................................spGhaaG+lpP...c.s.sp.sllct..........hhpG.cl..l......hhRG..............................................	0	98	225	312
+6828	PF07000	DUF1308		Protein of unknown function (DUF1308)	Moxon SJ	anon	Pfam-B_13288 (release 10.0)	Family	This family consists of several hypothetical eukaryotic sequences of around 400 residues in length. The function of this family is unknown.	25.00	25.00	26.30	25.60	19.30	24.50	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.13	0.70	-5.81	24	258	2009-01-15 18:05:59	2003-08-19 16:33:44	6	6	206	0	175	260	1	339.80	24	77.84	CHANGED	+LpsplpuEL+hLp+lpsthssh.....................................................h.pplpSoNLsaaculhpthcp.ppslsult+sF......................shpc.sts.........plhVDlVussGpp..WVKV.stsscpLhhphttps..............................p.sshsllc.ApshlpAupts.sta+p.Pclhhlh........................................hss..ssl.hcpl+phG.....lsl...............................hhtstststss.....h.......tsshtph.s........s..htshssplNlDsTsLlAhVSslSa.sssph.............hpc+hltcQhchE.+pcPlLsp.L.sthcu+cL.........................................................................................................................lsscpAscchp-Il-TlGGssE+pRuppLhtpl.hl.s.....................................Pst...phppLht.ttlphpslplFuhssthchshhTsNtth.lcuApppGhhhsVhp+ss+sLo	.......................................................................................................................................h.p.lttEhp.Lpph.t....................................................tth.oo...Nhsahpslhp....hpp...........pslsul.p.F................................................thtt..............tlhVDlVs..s..sG..tp..WlKshshps.ctLh...hhtpu............................................................p.s..phs.llcpApchlpAup........tp....h..tapp.....P+..lhhhh...................................................................................................ssh.s.h..hcplc.phG........lp.....................................................................t.ptst.....................t.s..p..t..h..t...s....................p...hsphspp...l..NLDhTsLlshVSsloa.sssph....................................................hppchlp..cQh.....p..E........pp.....p..............lhsp.L.s..hhp....s..+.pL.........................................................................................................................hssppAhpphppIlphlGsssE+pRsp.Lht.p.......s..................................................................ph.pl........p.p....ph..a.shs.thph.hhss....s...t....th....lpts..p..uh.....hh...s................................................................................................................................................	0	49	91	138
+6829	PF07001	BAT2_N		BAT2 N-terminus	Vella Briffa B	anon	Pfam-B_9101 (release 10.0)	Family	This family represents the N-terminus (approximately 200 residues) of the proline-rich protein BAT2. BAT2 is similar to other proteins with large proline-rich domains, such as some nuclear proteins, collagens, elastin, and synapsin [1].	25.00	25.00	25.20	25.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.38	0.71	-3.95	10	243	2009-01-15 18:05:59	2003-08-19 16:36:34	6	1	87	\N	112	219	0	174.00	54	10.12	CHANGED	MS-+uGQssKuKDGK.KYuoLSLFcTY...KGKS.LEsQK..ssVssRHGLQSLGK.VuluRRMPPPANLPSLKAENKGNDPNVslVPKDGTGWASKQ-Qs-scsoss.sspsPEopPsss.ttsss.....pP.ss..sss.ls.uus+SWA.sSsppGupG-Gspt..plssap+cEFPoLQ.AAG-QDKusK-psssDpu	...........................................................................MS-+uGpssKuKDGK.KYuoLsLFspY....KGKS..lE..s..QK..ssVss.R.H.GLQSLGK.....VuhuRR.MPPPANLPSLKAE..NKGND.PNVsl.VPK..D.G.T.GW..AoKQ..-...Qp...-s....c..s...s.....s....s...t..ss...psPEs.P.s..t.ttssss.................ps.sust..s.sspVs..susKS.....WA...ssp...tu...up...s.s...G..h..t...lspa......ppEFPoLp.....AAG-Q-KssKEpts....s......................................................	0	25	38	65
+6830	PF07002	Copine		Copine	Vella Briffa B	anon	Pfam-B_9705 (release 10.0)	Family	This family represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca(2+)-dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth [1].	20.70	20.70	20.70	21.40	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.90	0.71	-4.45	18	1157	2012-10-10 16:07:06	2003-08-19 16:56:31	11	19	130	0	676	958	9	139.10	46	27.26	CHANGED	SLHaIusp.psNsYppAlptlGpslpsYDsDchhP...AaGFGu..phs..-hsVoHs...Fslshssps.spCsGlpGllssY+pslPplpLhGPTsFuPIIstsschApt....psuupYaVLLIloDG..lT............shppTh-AIVpAScLPLSIllVGVG	..........................................SLHalsPh...t....NtY......pAlhuVG.pllQcY..Do...D.....Kh......FP.................A.aGF..GA....pl..Ps...c.h.........p.V.SHp..............Fsl..............Nh...s...sp.s.....s...C.p..G.l......pG.l...l.puYppsLs.p....lpL......h........GP.T........s.......Fu.PlIscsAch.A......t................p...s...u......s.....p....Y.al.................LLIlTDGs...lo...........................Dh...p..pT.pcAIVp....AS.p..L.PhSIIIVGVG...............................................................	0	224	337	496
+6832	PF07004	SHIPPO-rpt	DUF1309;	Sperm-tail PG-rich repeat	Vella Briffa B	anon	Pfam-B_8734 (release 10.0)	Repeat	This family represents a short conserved region carrying a PGP motif that is repeated in eukaryotic proteins of sperm-tails. Shippo orthologues from some species may include up to 40 Pro-Gly-Pro repeats.	20.00	3.00	20.00	3.50	19.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.70	0.73	-8.34	0.73	-2.80	323	5278	2009-01-15 18:05:59	2003-08-19 17:13:05	7	51	129	0	3778	5557	23	31.00	24	51.20	CHANGED	sPGPG..s.Y...sspp...................................ttssh...shus+pptt	......................................................sPGPG....s.Y...........sspp....................................................................................t.sth......sht.t....h....................................................................	2	2124	2616	3195
+6833	PF07005	DUF1537	Hop; PF07005; 	Protein of unknown function, DUF1537	Vella Briffa B	anon	Pfam-B_8609 (release 10.0)	Family	This conserved region is found in proteins of unknown function in a range of Proteobacteria as well as the  Gram-positive Oceanobacillus iheyensis.	20.90	20.90	20.90	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.29	0.70	-4.67	131	1723	2009-01-15 18:05:59	2003-08-20 09:55:19	6	19	1153	4	415	1360	256	211.80	26	49.09	CHANGED	Qoptp.....luhlshssl....tG..st..slpsplsphtspuh.phslsDAhsspDLttlupAstphs..........LhsGuuG..luhuLst.....thtttshhst.tst.s.......................................ss...sllluGSsSssTppQlsth...psshss....lplDsttlh.....t.......ts.h.....ppshshstsphsps...ss.llassssspsspsspt.phthtttu.h............lppsLuplstpl.h...........pt.u..lppllluGG-TSusVsps.Lulsulclss	.......................................................Qst..ss.lshpsl......tpG..st....slpttLspl....p.....pp..Gh..phsVlDAls-pcLphhu.pAltp.ts..............LlsGuuG..luhuL.up.....p.hsptstttt...t..............................................sstsllluG...SsSphTppQlsth....c..p..t..s..ss...........hplD..stphl.......................p...htshh.......ppl..hphshsthspt....ts...llhso..t..s..s..p....s.htslpp.....th.t.....t.....p..thupt...........................lpphhuplstpl.h...........tp.s......lst.h.llsGG-TSu.sVsps.LGlpuhclt.......................................	1	108	236	339
+6834	PF07006	DUF1310		Protein of unknown function (DUF1310)	Moxon SJ	anon	Pfam-B_10153 (release 10.0)	Family	This family consists of several hypothetical proteins of around 125 residues in length. Members of this family seem to be specific to Listeria and Streptococcus species. The function of this family is unknown.	30.10	30.10	30.20	30.30	29.50	30.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.40	0.71	-4.60	18	373	2009-01-15 18:05:59	2003-08-20 10:41:32	6	2	106	0	22	303	0	116.40	36	85.44	CHANGED	K..+WllllhhhLlslhhlGuthYhcccpc....pc..EMhpllpS-EAKcVaEctLKslDscAhTccGlI+oYcIDcpSIcpNPMGGI.VcLlINcDscLhlpasLp+ss.pGcLcuuuhshSscLscLL	.....................hlhhhhlslhsh.h.hl.G.st.hhhs.p...cp........pp...EMhpllpScEsK.plhEctL+plDscAhTc...c...GhIpSYcIDcpSlcpNPMG.G.I.lpllIN.sD.clhlphslp+.....ps.....Gc.lpssu..hs..hStcLscLL..................................	0	5	6	17
+6835	PF07007	DUF1311		Protein of unknown function (DUF1311)	Moxon SJ	anon	Pfam-B_10506 (release 10.0)	Family	This family consists of several bacterial proteins of around 120 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.54	0.72	-3.89	182	2203	2009-09-11 12:01:10	2003-08-20 10:44:19	7	31	1231	2	507	1711	82	90.10	22	47.59	CHANGED	sC....psst..sssphth.Cs..stp..hpthDpcLspsY...pphhpphs.............tttt........ptLc...p....uQ+sWlph.R-tpCthttt..........t...........tsCh..hphsppRhtpL	..........................................................C....ttst..st.hphhh..Ct...s.tp..hpthDtcLspsY...pphhpphp............t.tp....................stLp.p......uQ..psWlph..R-t.pCt.h...t.............................hsChhphsppRhttL............................................	0	105	233	375
+6837	PF07009	DUF1312		Protein of unknown function (DUF1312)	Moxon SJ	anon	Pfam-B_10829 (release 10.0)	Family	This family consists of several bacterial proteins of around 120 residues in length. The function of this family is unknown.	29.60	29.60	31.60	30.10	29.30	28.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.37	0.71	-4.26	40	812	2009-01-15 18:05:59	2003-08-20 10:52:32	6	4	615	16	142	554	21	112.80	29	80.84	CHANGED	ll.llllllluhhslhhh.............t.psspsthAlIpl-G+lhpplsLsc.ptspphpl....psspthNllclcsspl+hp-us...CPDplCV+pGhIs+sGps.IlCLPp+llIcIp...uspp.pp	............................................................................lIhhlllhu.hhslhhh......................tttppsssthAl.l.pl.....-G..c..hc.phsLsp..t..ppphpl...................sspsthN.hl-.l.cssclRlp-us...CPDplCV+pGaIs+.sG.......po..IlCLPc+lllclcuspt..s..............	0	74	124	133
+6838	PF07010	Endomucin		Endomucin	Moxon SJ	anon	Pfam-B_10834 (release 10.0)	Family	This family consists of several mammalian endomucin proteins. Endomucin is an early endothelial-specific antigen that is also expressed on putative hematopoietic progenitor cells. 	20.90	20.90	20.90	23.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.73	0.70	-5.05	3	39	2009-01-15 18:05:59	2003-08-20 11:05:11	7	2	26	0	17	52	0	160.40	53	87.87	CHANGED	MRLLQVTlLFFLLSNSLC+SEsuK-stNsSLs...ETSTTKASlTTPshVSl.pNsNKPTsGTPPKGTTsS-lsKTSLMoTlsSLTTPKHEltTTTcGVlKNESSThKlTVsNsTlSNAVSTLsSSQNKTENQSSIRTTEI.ssTslL.sDApPKpTuT.oSASLTTA+ThSQlQ..DTEDGKIAoToSTTPSYSSIILPVVIALIVITLLVFTLVGLYRICWKRDPGTPENGNDQPQSDKESVKLLTVKTISHESGEHSAQGKTKN	.........................................................................................................................................................................................................s.....................................s.s...........t.tp.sss.t.s......ShSu.II.LPVVIALIVITLSVFlLVGLYRhCWKsDPG.s.EsGs.-QPQSDKESVKLLTVKTISHEoG.......................	0	1	1	4
+6839	PF07011	DUF1313		Protein of unknown function (DUF1313)	Moxon SJ	anon	Pfam-B_10989 (release 10.0)	Family	This family consists of several hypothetical plant proteins of around 100 residues in length. The function of this family is unknown.	20.40	20.40	20.50	60.40	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.98	0.72	-4.32	12	107	2009-01-15 18:05:59	2003-08-20 11:07:00	6	2	42	0	55	103	1	87.10	52	69.78	CHANGED	stutDuclhpshppSFsQVQulLDQNRhLIpclNpNHpSRhsDsLsRNVuLIRELNsNIp+VlslYuDLSssFupsh..ctupp....ussosss	...........s.tsDsKlhpsFp+SFsQVQslLDQNRlLIsEINQNHES+hPDNLoRNVuLIRELNsNIpRVVsLYuDLSsoFs.+oh.csssp....upss..s................	0	9	37	47
+6840	PF07012	Curlin_rpt		Curlin associated repeat	Moxon SJ	anon	Pfam-B_10299 (release 10.0)	Repeat	This family consists of several bacterial repeats of around 30 residues in length. These repeats are often found in multiple copies in the curlin proteins CsgA and CsgB. Curli fibres are thin aggregative surface fibres, connected with adhesion, which bind laminin, fibronectin, plasminogen, human contact phase proteins, and major histocompatibility complex (MHC) class I molecules. Curli fibres are coded for by the csg gene cluster, which is comprised of two divergently transcribed operons. One operon encodes the csgB, csgA, and csgC genes, while the other encodes csgD, csgE, csgF, and csgG. The assembly of the fibres is unique and involves extracellular self-assembly of the curlin subunit (CsgA), dependent on a specific nucleator protein (CsgB). CsgD is a transcriptional activator essential for expression of the two curli fibre operons, and CsgG is an outer membrane lipoprotein involved in extracellular stabilisation of CsgA and CsgB [1]. 	20.70	20.70	21.10	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.46	0.72	-4.23	22	2923	2009-01-15 18:05:59	2003-08-20 11:21:28	7	10	529	0	240	818	103	32.30	40	50.36	CHANGED	GssNssslp.QtGssN......tuhlsQh.GssNpsplsQtG	..............sssp.hplp.Q.t.GssN............sAh.ls..Qp..Gs.ss.cssloQhG..........	0	40	67	153
+6841	PF07013	DUF1314		Protein of unknown function (DUF1314)	Moxon SJ	anon	Pfam-B_10999 (release 10.0)	Family	This family consists of several Alphaherpesvirus proteins of around 200 residues in length. The function of this family is unknown.	25.00	25.00	90.20	89.90	22.40	16.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.14	0.71	-4.88	5	24	2009-01-15 18:05:59	2003-08-20 11:24:38	6	1	18	0	0	20	0	170.40	41	75.45	CHANGED	c+sLLcuLuGRslDLPGGG-.LtIssssGps...hs+FspuGouRsshl+aIGRAhTsGssRcFlIatu+-..GsVYGYEsuTGLHhLAcSLHDFLsp+GLSQRDLhVlcGshhcuclssLsh..phh+soS-ssplssp.oschstsTsssuctspSoo+Rs...oLuslss....shpsp+lls+GS	scsLLcsLuGRslDLPGGs-.ltIssssGps...ht+appsGsp+hshs+hIGRAhs.GssRcFllhhs+s..uslaGYEsuTGLHhLApSLH-FLpppGLSpRDLhlhcushhshphpslsh....hpsoops.plshp.sss..hsTtsssptppooocRs...sLsslss.....hpspphls+GS.............................	0	0	0	0
+6842	PF07014	Hs1pro-1_C	Hs1pro-1; 	Hs1pro-1 protein C-terminus	Moxon SJ, Vella Briffa B	anon	Pfam-B_11205 (release 10.0)	Family	This family represents the C-terminus (approximately 270 residues) of a number of plant Hs1pro-1 proteins, which are believed to confer nematode resistance [1].	25.00	25.00	68.20	63.10	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.88	0.70	-5.06	5	41	2009-09-11 08:44:19	2003-08-20 12:04:16	7	3	20	0	24	44	8	248.10	56	59.96	CHANGED	MpRCsYTLGLGEPNLAGKPsLcYDAVCRPsELHALK.......csPYsD+I-NpENQsLaTIHQILESWIauSspLLsRIssRIEcc+FEKAAsDCYlLERIWKLLAEIEDLHLLMDP-DFL+LKcQLpIKSou.cs-AFCFRSKGLVEVsKMSKDLR+KVPsVLuVEVDPsGGPRlQEAAMKLY..cRKoEaE...KIHLLQAMQAVEuAsKRFFFGY+QLVAAMMGSAEANANRslh..SsESsDSLoQlFLEPTYFPSLDAAKTFLG-FWs+c	......MptCsaTLGLGEPNLAGKPsLcYDtVC+PpElHuLK.......posa..hh..c.NpENcsLaThHQIlESWlpsuppLLpRlscpIcs+saEtAApDCallERlWKLLs-lEDLHLlMDPDDFLRLKpQL........ul....+......oss..p...s........u.....uFCFRS+tLlcls+hs+DL+++VPplLuVEVDPpGGPRlQEAAM+LY........pc+sthE...............KlaLLQAhQAlEsAh+pFFauY+QllssVMGouEupustshh..ss-uhDsLoQhFLEPsYFPSLDAAKTFLupaWsp.p...............	0	8	17	20
+6843	PF07015	VirC1		VirC1 protein	Moxon SJ	anon	Pfam-B_11309 (release 10.0)	Family	This family consists of several bacterial VirC1 proteins. In Agrobacterium tumefaciens, a cis-active 24-base-pair sequence adjacent to the right border of the T-DNA, called overdrive, stimulates tumour formation by increasing the level of T-DNA processing. It is thought that the virC operon which enhances T-DNA processing probably does so because the VirC1 protein interacts with overdrive. It has now been shown that the virC1 gene product binds to overdrive but not to the right border of T-DNA [1]. 	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.35	0.70	-5.28	4	74	2012-10-05 12:31:09	2003-08-20 12:08:44	6	2	60	0	21	1997	816	212.80	28	93.83	CHANGED	MpLlThCSFKGGAGKTTALMGLCuuLAucG+RVALFEADENRPLo+W+ENAhppusWDstCElasADELPLLEsAYEpAEspGFDYALADT+GGuSELNNTIIASSsLLLIPTMLTPLDlDEALuTYRYllELL.luEsLsIPsAILRQRVPssRLToSQphh.-MLEpLPlhDsPMaERDAFAAMK-RGMLHlsltNhupsPoMRLhhRNlctAh--lshluchlpcsLEu	........................M.llshsS.KGGuGKTT..u.h..hhLu..s.tl....A.....p.....p..G.....p....p..Vs.....llDAD....s..N.........p....s...l.s.p....W.....t..p..t....s.......t..t...s.......s...h......s......s........h...p......l....h..s..s..s...c......s...h..l...c..th....h...p....p...s...p..t..p.s.h...s.al.l.lDh...c.G....s..u...o...t..h..s.s...h...s..Iu.p..u.D.lllI...Psthoth..Dh...c....pAhp.sh.phlt..c.......h...psh..p..h...p....I...P..h....s.V..l.h...o..+..s...s....s....t....t..h.pp...t.p..c.h.h.p.-h.....h......p...p......l.....P.......l...h...p...s.......hh-.R....sAa..pu..h.hp.h.G..h.............................................................tt...................................................................................................................................................	0	7	17	19
+6844	PF07016	CRAM_rpt		Cysteine-rich acidic integral membrane protein precursor	Moxon SJ	anon	Pfam-B_11042 (release 10.0)	Repeat	This family consists of several 24 residue repeats from the Trypanosoma brucei cysteine-rich, acidic integral membrane protein precursor (CRAM). CRAM is concentrated in the flagellar pocket, an invagination of the cell surface of the trypanosome where endocytosis has been documented [1].	19.10	19.10	27.40	19.60	16.00	15.40	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-7.89	0.72	-4.60	2	132	2009-01-15 18:05:59	2003-08-20 12:15:35	6	4	4	0	60	150	0	23.90	95	108.27	CHANGED	.sDDCNITGDCNETDDCsITGDCN	.ETDDCNITGDCNETDDCNITGDCN....	0	2	60	60
+6845	PF07017	PagP		Antimicrobial peptide resistance and lipid A acylation protein PagP	Moxon SJ	anon	Pfam-B_11014 (release 10.0)	Family	This family consists of several bacterial antimicrobial peptide resistance and lipid A acylation (PagP) proteins. The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response. 	21.90	21.90	22.90	24.40	21.40	18.60	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.96	0.71	-4.89	10	610	2009-09-10 16:46:51	2003-08-20 13:10:46	6	3	581	4	62	268	7	143.80	76	77.22	CHANGED	pNVupTWsps.spDLYlPslTWHNRasYDcEKIDsYNE+PWGuGYGhSRYDEcGsWHGLYhMAFpDSHN+aEPIsGYGapKhWpPsp..pDa+hGlGaTAulTARc-a.sYIPIPslLPLASluY+plohQuTYIPG....TYNNGNVLFuWhR	..........................NlApTWpQPEHYDLYlPAITWHARFAYDKEKT..DRYNERPWGuGFGhSRWDEKGNWHGLY..AMAFKDSaNKWEPIuGYGWEpTWRPL.s.D.-NF+LGLGFTAGV..TAR....DN.W.NYIPlPVLLPLASlGYGPsTFQMT...YIPG....TYN.NGNVYFAWMR................................	0	4	23	43
+6847	PF07019	Rab5ip		Rab5-interacting protein (Rab5ip)	Moxon SJ	anon	Pfam-B_11031 (release 10.0)	Family	This family consists of several Rab5-interacting protein (RIP5 or Rab5ip ) sequences. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5 [1].	21.40	21.40	21.60	21.50	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.67	0.72	-3.85	38	446	2009-01-15 18:05:59	2003-08-20 13:25:37	7	12	273	0	301	409	2	82.00	27	60.80	CHANGED	pslhasRphh.........ullhGlsuGlLsLpGhh.Ghlhahlsshhhshhhhs..phtpss.........cpaatshpclh.hpGlhsulss..........Fl....lsWshh..........Y	............sl.ahRphh.........ullhGlsuGlLsLpGhh.GFlha..hlhshhlsh.lhhs...pht.p.s.................................cpha.t.u.hhplh.ppG..hhs..uhhs........................Fl....lhWhhhY...............................................	0	96	159	244
+6848	PF07020	Orthopox_C10L		Orthopoxvirus C10L protein	Moxon SJ	anon	Pfam-B_12732 (release 10.0)	Family	This family consists of several Orthopoxvirus C10L proteins. C10L viral protein can play an important role in vaccinia virus evasion of the host immune system. It may consist in the blockade of IL-1 receptors by the C10L protein, a homologue of the IL-1 Ra [1]. 	25.00	25.00	34.80	32.80	22.10	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.31	0.72	-3.45	4	34	2009-01-15 18:05:59	2003-08-20 13:30:38	6	1	19	\N	0	28	0	62.90	80	98.48	CHANGED	MSucGt....SpGGhapsFhps.sGusKts+ohoSGGG........uMWGG......................GuSuGlpuGVpGGVNGGVNuGsuKI	...MSSKGG.....SGGMWSVFIHGHDGSNKGSKTYTSGGG...........GMWGG.......................SSS..GVKSGVpGGVNGGVKSGTGKI....	0	0	0	0
+6849	PF07021	MetW		Methionine biosynthesis protein MetW	Moxon SJ	anon	Pfam-B_11086 (release 10.0)	Family	This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalysed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganisms the reaction is catalysed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells [1]. 	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.11	0.71	-4.93	6	667	2012-10-10 17:06:42	2003-08-20 13:50:55	7	7	656	0	204	5525	4101	186.90	43	86.71	CHANGED	RsDachItchI.PGSRVLDlGCGDGsLLpLLp-pKpVcGpGlElspsGVscClA+GLsVlQGDhDpsLspasD+uFDaVlLSQTLQATRNPcpVL-EhLRIG++sIVSFPNFGHW+sRhpLhs+GRMPVTcsLPYsWYsTPNIHFCTltDFhpLCc-lshpl-cpsAlcttut.h...hspah.NahGchulFhl	.............................................................R.Dh.p..l..Itc.h..l......s...s...S...R...V...L.DL..G.C.G........D.G....p....L....L....p....h.......L.....t........c......p...........+.........p......s........p....G...........h....G.....l.........E....l..........D.........p........s.......s........l..........h.........s......s.........l......u..........+..........G.........l......s........V.............I....p..........t......D........L......-.........c.....G.............L.......s......p.................F..........s......D.....p......S...F...D...h.V.l..L...S....Q.......T...L....Q...A...l....c.....p...P....-.....t......l.....L.....c....E....h....h....R...l.......G....+.....p.....s..I.....V.....o.F.....P..N......F.....G...a........W...+.....s..R.h.....p....l..h..........p......G.+.M...P......V.....o..cp....L......P.Yp.WYs..T............P..N...I.+.......h...s.TlcDFE.tLstch.s..l..cl.l..c...R.hs.l.stpp..............hsphhPNLhuphAlahl....................................................................................................................................	0	67	135	169
+6850	PF07022	Phage_CI_repr		Bacteriophage CI repressor helix-turn-helix domain	Moxon SJ, Bateman A	anon	Pfam-B_11145 (release 10.0)	Domain	This family consists of several phage CI repressor proteins and related bacterial sequences. The CI repressor is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-9.03	0.72	-3.89	14	693	2012-10-04 14:01:12	2003-08-20 13:57:29	8	9	476	2	136	1419	82	63.90	28	33.13	CHANGED	sslcRlhcAYGFpscppLusaLulu+SThu......................................................................................................shhtR-phP.u-hllpCuLETGsSLpWLssGcGphh	.......................hlcRlhpsh...sh..p..s......p..p..pLuch.LGlupuTlu......................................................................sh.h.t..R...s..s..h..P...s-.h.ll..p.h.u.h...c..s..G.lslpW.LhsGpGt...................................................	0	33	82	113
+6851	PF07023	DUF1315		Protein of unknown function (DUF1315)	Moxon SJ	anon	Pfam-B_11170 (release 10.0)	Family	This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.	25.00	25.00	32.80	32.80	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.27	0.72	-4.10	26	846	2012-10-03 10:59:06	2003-08-20 14:00:57	7	1	840	0	114	362	43	88.00	57	95.55	CHANGED	h-pllpshTPElYppLppAVElGKWPDGpsLTsEQ+-sshQAVMhYps+Hshssccho....GplshKoKpphpt.......................pslthhp	....l.--lIsuMTPEVYQRLsTAVELGKWPDGVALTpEQKENsLQlVMLWQARHNs-AQHMTIsTsGpMVMKSKQpLKccFuhs........................scshshhc.....................	0	17	40	80
+6852	PF07024	ImpE		ImpE protein	Moxon SJ	anon	Pfam-B_11208 (release 10.0)	Family	This family consists of several bacterial proteins including ImpE (Swiss:Q93EC9) from Rhizobium leguminosarum. It has been suggested that the imp locus is involved in the secretion to the environment of proteins, including periplasmic RbsB protein, that cause blocking of infection specifically in pea plants [1]. The exact function of this family is unknown.	25.00	25.00	38.40	77.50	23.60	18.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.53	0.71	-4.16	36	372	2009-09-10 16:41:21	2003-08-20 14:24:06	8	4	347	1	71	256	11	123.30	43	45.34	CHANGED	sussFsWlsDuDsRLGPshEll.ssGpYhWlPaupIpslchpsPusLhDllWpPspls....ltsGststualPsRYsuotps........................ssAh+LGRcTcWp-.hups.shhGhGQ+hahssss-huLh-lpplph	........sssFsWluDSDoRLGPVhEll.suGsYhWlPFupIpSLchspPspLpDLlWpPspls....LhsGssttualPsRYsuScpu..................................sDulRLuRcTsWp.........-....sucs.....sshulGQKsWlT.s...pG-huLhDltphpF......	0	13	30	52
+6854	PF07026	DUF1317		Protein of unknown function (DUF1317)	Moxon SJ	anon	Pfam-B_12646 (release 10.0)	Family	This family consists of several hypothetical bacterial and phage proteins of around 60 residues in length. The function of this family is unknown.	20.60	20.60	20.90	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.92	0.72	-4.09	2	125	2009-09-11 12:57:57	2003-08-20 15:10:15	6	1	114	0	4	77	0	57.50	79	96.27	CHANGED	MKHsHDsIpVGtlhhsYSsh+pGWlhPGhplh+NPhpA.phAEEhNNhhtulpsc...Ls	...........MpHPHDNIRVGuITFVYSVTKRGWVFPGLSVIRNPLKAQRLAEcINNKRsAVCTKHL.LS..................	0	1	2	3
+6855	PF07027	DUF1318		Protein of unknown function (DUF1318)	Moxon SJ	anon	Pfam-B_11321 (release 10.0)	Family	This family consists of several bacterial proteins of around 100 residues in length and is often known as YdbL. The function of this family is unknown.	20.80	20.80	21.00	20.80	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.04	0.72	-3.75	54	739	2009-01-15 18:05:59	2003-08-20 15:21:49	7	2	731	0	142	388	33	94.30	54	81.96	CHANGED	hhuhsu......hAh.sLspA+upGlVGEphsGYLulVt..sss-s.psLVpsINtpR+ApYpclApcN.slol-pVuphAupKhl.p+stsGpalps.sGpWh.+K	.....................................L.hosss.hAL..TL-EARoQGRVGEThsGYL......s.....s......l+.............s......D......AE.....T..ppLVp-INttR+AuYQQLAc.........p......N.sl...o....l..--...lAK...lAGQ.KLV.tRA+PGEYVQGINGKWlRK.........	0	43	80	112
+6856	PF07028	DUF1319		Protein of unknown function (DUF1319)	Vella Briffa B	anon	Pfam-B_10434 (release 10.0)	Family	This family contains a number of viral proteins of unknown function approximately 200 residues long. Family members seem to be restricted to badnaviruses.	28.10	28.10	28.20	59.30	26.30	28.00	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.64	0.71	-3.94	11	50	2009-01-15 18:05:59	2003-08-20 15:23:18	6	1	29	0	0	50	0	127.20	41	80.65	CHANGED	Spps...pL-YLDLAopsKsS..sp-LAHNLplsscRlsLts+V...........................plpplppI.+p.ctpLcclcpclcpLpc-LpsLcp-alpR+PLSKp-Vc-LVlcIoEQPKhIEcQoEtLocELpccV-cl	............t...pL-YLDL.tots...Klo..Np-LuHNLplsh.RhsLss+V...................................plcphppI.cp....lcchp.pclctLppcLpsLpp-alc++PLoKp-VccLVlcIuEQPKhIEcQs.tLoc-Lppclccl.................	0	0	0	0
+6857	PF07029	CryBP1		CryBP1 protein	Moxon SJ	anon	Pfam-B_11415 (release 10.0)	Family	This family consists of several CryBP1 like proteins from Bacillus thuringiensis and Paenibacillus popilliae. Members of this family are thought to be involved in the overall toxicity of the bacteria to their hosts [1,2].	19.50	19.50	20.80	20.30	19.20	18.10	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.91	0.71	-4.49	5	45	2009-01-15 18:05:59	2003-08-20 15:29:38	6	1	21	0	4	42	0	155.90	37	85.48	CHANGED	pElPcplo.ctppKlPFCCVVSIP+GFchVusscPKLVYsLssLSllKETCRKsVpVD-CGpAEVDLHVLKVKGCIPFIuNlEVcPIsscpsCoosPHccpISLSCp-oVCVDHVLKCSVssLPDacIDCcaVsVsDLplpPl+EssCQFVKIoGpFsFaYl	........................thp.ctpp+lPFCCllSlPpGFplhss....s.p.KlVYslssLuhlKETC+KslpV--CGpsElDLpVLKlKGCIsF.lsNh.plc..Phsppphsoo.s....s.........+sppIsLSCpsoVsVDplL..KhSVs..p..LPchpIsspplplpDlplpsh....pEssp...phl+loGtFpFh...........................................................	0	3	4	4
+6858	PF07030	DUF1320		Protein of unknown function (DUF1320)	Moxon SJ	anon	Pfam-B_13638 (release 10.0)	Family	This family consists of both hypothetical bacterial and phage proteins of around 145 residues in length. The function of this family is unknown.	20.70	20.70	21.20	20.80	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.61	0.71	-4.41	48	429	2009-01-15 18:05:59	2003-08-20 15:31:54	7	1	362	0	75	343	19	130.70	24	89.87	CHANGED	YsThsDLhsphuppplhp.................L..sscs.........ssths.shlppAls-AsstIDuaLtuR.Ys...LPL..ssVPslLpphssslAcYhLhspcst.....s-t......lpccYc.pAl+hLcplusGclsLGlss.........ssssssssststhpuspp	................................Yso.pD.lh.tphspp...tlhp..........................L.....ospp...........ssthsps.hlppAls-.Asu.IDuYLtsR....Yp...............l.P.l..............sss.Psl..LpphssslAh.Yp.L.tspps.........s-p........lcccYc.pAlchLcplusGcl..sLulss........ttts..tt.s...h.....tt....................................	0	32	58	67
+6860	PF07032	DUF1322		Protein of unknown function (DUF1322)	Moxon SJ	anon	Pfam-B_13233 (release 10.0)	Family	This family consists of several hypothetical 9.4 kDa Borrelia burgdorferi (Lyme disease spirochete) proteins of around 78 residues in length. The function of this family is unknown.	19.60	19.60	20.00	21.40	19.10	19.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.73	0.72	-3.78	2	124	2009-01-15 18:05:59	2003-08-20 15:53:41	6	2	29	0	8	73	1	72.70	69	85.59	CHANGED	MsK............sEhtppYFphlD.l..cssKYYFPllhsICoYcDVKKh.YcELLEVNRlAslKLpKEhYEhhLuh	..............MpKhN+DIDKAIASLNEoRKKYFNLLDEI..KNDK..YYFPVIMNICSYcsVKKLPYDELLEVNRlA-lKLEKE.LYELILSK...............	3	5	5	5
+6861	PF07033	Orthopox_B11R		Orthopoxvirus B11R protein	Moxon SJ	anon	Pfam-B_13245 (release 10.0)	Family	This family consists of several Orthopoxvirus B11R proteins of around 70 residues in length. The function of this family is unknown.	25.00	25.00	141.50	141.50	20.80	19.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.36	0.72	-4.50	2	31	2009-09-11 15:28:16	2003-08-20 15:58:21	6	1	12	0	0	30	0	71.10	94	81.57	CHANGED	DTsssNVEDIMNEIDREKEEILKNVEhENNKNIpKNHPsEYIREALVINTSSsSDSIDKEVIECISpsVGI	..DTDV.TNVEDIhNEIDREKEEILKNVEIENNKNINKNHPSEYIREALVINTSSNSDSIDKEVIECISHDVGI	0	0	0	0
+6862	PF07034	ORC3_N		Origin recognition complex (ORC) subunit 3 N-terminus	Vella Briffa B	anon	Pfam-B_10452 (release 10.0)	Family	This family represents the N-terminus (approximately 300 residues) of subunit 3 of the eukaryotic origin recognition complex (ORC). Origin recognition complex (ORC) is composed of six subunits that are essential for cell viability. They collectively bind to the autonomously replicating sequence (ARS) in a sequence-specific manner and lead to the chromatin loading of other replication factors that are essential for initiation of DNA replication [1].	22.30	22.30	22.30	22.80	20.60	22.20	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.95	0.70	-5.47	13	289	2009-01-15 18:05:59	2003-08-20 16:27:21	6	7	223	0	199	294	2	270.20	24	40.30	CHANGED	K..R............Kputspcsh..hpssspsscchhsphRacsapphWpplcsph-clQcphNt+lh-sLlcFlccstpstptp...h.tp.............pclPTAALls...............GlNhsDH.hpFpsLoppL+sssssaVshLpS+DCsu........lKthlpplltQL......hcsssslctc-p-...........ht.p+sphslssLsoWYp..................pppphsssp.pp................................PlVVIlcDhEsFsspVLQDFIlIhSpalpclPllLVFGlATossulHplLPapVSShLslclFQo.ussppLssVlDclLLosphPF+LSuKVhplLpsIFLYHDFSlpuFI+Gl............KhuhlEHFhspPLSsL	..................................................................................................................t.p..................................p.thphhp.hWtt.pt.ph..p.........pl.pphptphhppl.pFlppt..t...........................................tplPsuhlhh......................GsNh.ssp.hhhppL..tp..tl.p...p.....p........s........s.....h...l...s.L.p.ut-sss.........................................l.+thlppllpph....................................hs.p..s..p.t..p.....................................t..ph...th....s...hp.Lt..saat........................................p..pht..................................................................................................................................................................lVllhcDhE.uFs.splLpDhlhl...h.....S..p..a........h..p........c...........l...........Phh....llhGl..A..T..os..ph..hc...phLsps.sss..h.......Lph....p..h....F...p......sspphlsplhcpllh....s....s.p....h....s..........h...p..l..utplhp.hLhs.hah...pshSlpsFlpul............phshhpHFaspPLShL....................................	0	59	105	159
+6863	PF07035	Mic1		Colon cancer-associated protein Mic1-like	Vella Briffa B	anon	Pfam-B_10041 (release 10.0)	Family	This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.	20.80	20.80	21.20	23.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.69	0.71	-4.89	5	183	2009-01-15 18:05:59	2003-08-20 17:08:55	7	2	131	0	123	177	0	150.30	34	25.00	CHANGED	chhtccsYlluIlMEYLRSLsctpIssptpLacMlIcpLApuscFscLppFVoY+lLp-SKsLAhhLLShuspsosl+QLGlDML+RluhAHDhIlEVLLpcGplL-ALRaA+chtslssVpusKFLEAApposDsQphaAIhRFFoE+p.+h.hh.uFssshcTsE	............................................h..pallullhEYlRSLsp...hp.Is....sp.ch.LacllIptLlppp.t.ahhLcphlpY+VlsDSKslA..phL..LShp..........s..h............a..........ss.s..pQLuLDML+RLs.up-tIlElLLsctplLtALRah+sh.....tt...hss.........l...ss..p+.........FL-AAhpspDs.lhaslh+FFpp..........F.....................................	0	47	65	97
+6865	PF07037	DUF1323		Putative transcription regulator (DUF1323)	Moxon SJ, Bateman A	anon	Pfam-B_12705 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 120 residues in length. This family appears to have an HTH domain and is therefore likely to act as a transcriptional regulator.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.52	0.71	-3.94	10	925	2012-10-04 14:01:12	2003-08-21 10:48:22	6	1	468	0	36	265	4	117.00	62	94.57	CHANGED	MTPEELAchoGYoRQTIN+WVRKcGW+TpPhPGVpGG+ARLlHlsppVREFIpsss..........RlsEssAtY.sssscusl.s.llsslcpMTssEQcQLssLLsREGIsGLLpRLGIR-s	......................MTsEELAchhG..h..uR..QTlN+Wl..Rc.cGWp...Tp.hPGV..pG.G.+.AR...Ll..H.VspQVREaIpNs...........cs.EshAEh..Asuu.cAPh.t.llohscpMTssEQcphsphLsREGI..pGhLpRLGIc-S....................................................................................	0	3	3	21
+6866	PF07038	DUF1324		Protein of unknown function (DUF1324)	Moxon SJ	anon	Pfam-B_12735 (release 10.0)	Family	This family consists of several Circovirus proteins of around 60 residues in length. The function of this family is unknown.	25.00	25.00	140.50	140.30	19.30	18.10	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.11	0.72	-3.94	2	9	2009-01-15 18:05:59	2003-08-21 11:20:11	6	1	6	0	0	7	0	59.00	97	94.82	CHANGED	MpCTLVFQSRFCIFPLTFKSSASPRKFLTNVTGCC.ATVTRlPLSNKVLTAVDRSLRCP	MTCTLVFQSRFCIFPLTFKSSASPRKFLTNVTGCCSATVTRLPLSNKVLTAVDRSLRCP	0	0	0	0
+6867	PF07039	DUF1325		SGF29 tudor-like domain	Moxon SJ, Bateman A	anon	Pfam-B_13304 (release 10.0)	Domain	This domain is found in the yeast protein SAGA-associated factor 29. This domain is related to members of the Tudor domain superfamily such as Pfam:PF05641. The SAGA complex is involved in RNA polymerase II-dependent transcriptional regulation. The membership of the tudor domain superfamily suggests this domain may bind to RNA.	25.30	25.30	25.40	30.20	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.91	0.71	-4.53	20	328	2012-10-02 16:56:36	2003-08-21 11:28:18	6	4	260	14	233	311	5	129.80	33	39.46	CHANGED	phG-pVAAphp.......psstc.........p-WIlucVlphsscs..p+YEVhDsDs-...ppt...taphot+clIPLPp.......s.cssstspFPpGopVLAlYPp.....TTsFY+AhVhss.................sp....ptsspYpLcF-D-p.sst....hpVsp+aVlshsp	....................................h..GspVAh+sp..........ttstc................ppWIlscVlp.hstps...p+......YEVpD.-s-..............ppp.......paphotpplIPl.Pp.......t.pssshs.F.stGppVLAlYPp.......TTsFY+AhVhus.............................................t........pt.p..s...s...YplpF-s-ptsst.....hpVspRaVlsh..p..........................	0	86	129	193
+6868	PF07040	DUF1326		Protein of unknown function (DUF1326)	Moxon SJ	anon	Pfam-B_11597 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins which seem to be found exclusively in Rhizobium and Ralstonia species. Members of this family are typically around 210 residues in length and contain 5 highly conserved cysteine residues at their N-terminus. The function of this family is unknown.	25.00	25.00	29.30	29.30	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.14	0.71	-4.52	34	220	2009-01-15 18:05:59	2003-08-21 11:31:31	6	2	187	0	80	216	231	181.30	31	86.66	CHANGED	htsCsCshhCPC.hs......t.PTp..GtCcuhhuhcI-cGpasslcLsGLsluhlhchPGs.ht-G.....shcssh....alD-cAo-tQhcALhpIhoGps....Gu.hushusllu.chhusthsPIcacscspt......ps..lplsshhphth-shhpPhsGsstcs.hslssssa..........hphucsspsph..pshGh.sachss..ppu	....................h.tsCsCshhCPC.hu......tsPTp..G....pCcuhhua+I-cGpas-lcLsGLsluhls....ph.P....Gs....lt...cG.....shcssh....alD-RAossQtcALhpIaoGps....GGhhuhFuph.lu.chhuschAPIca-scscp......ts....lcls.sh.hp....s.hsPhsGsstcs.hslssssap..h.st...hthucss.psph...cshGh.shshsspp............................................................................................	0	23	49	63
+6869	PF07041	DUF1327		Protein of unknown function (DUF1327)	Moxon SJ	anon	Pfam-B_11630 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 115 residues in length which seem to be specific to Escherichia coli. The function of this family is unknown.	25.00	25.00	25.50	25.30	24.30	23.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.48	0.71	-4.17	3	518	2009-01-15 18:05:59	2003-08-21 11:33:54	6	1	251	0	5	248	0	105.10	69	80.18	CHANGED	MTQDYELVVKGVRNFENKVTVTVALcDKc+FDGEIFDLDISLDRVEGAALEFYEAAARRSlRQVFLDVAAGLCEGDEpLPEKRPlILEAQsVhITY+GKLPGhITGSLKTPPs	.....MppcYELlVKGIpNa.sKlTVTVALc.tth.sh.l.DlsISLDRsEGAsLEFYEAtA++ps+QhFhDVAAGLCEGDt.LPEKRPlILEAQsVhITY+GKLPGhITGSLKhPP..........................	0	1	1	1
+6870	PF07042	TrfA		TrfA protein	Moxon SJ	anon	Pfam-B_12321 (release 10.0)	Family	This family consists of several bacterial TrfA proteins. The trfA operon of broad-host-range IncP plasmids is essential to activate the origin of vegetative replication in diverse species. The trfA operon encodes two ORFs. The first ORF is highly conserved and encodes a putative single-stranded DNA binding protein (Ssb). The second, trfA, contains two translational starts as in the IncP alpha plasmids, generating related polypeptides of 406 (TrfA1) and 282 (TrfA2) amino acids. TrfA2 is very similar to the IncP alpha product, whereas the N-terminal region of TrfA1 shows very little similarity to the equivalent region of IncP alpha TrfA1. This region has been implicated in the ability of IncP alpha plasmids to replicate efficiently in Pseudomonas aeruginosa [1].	20.20	20.20	20.60	20.20	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.93	0.70	-5.59	2	183	2012-10-04 14:01:12	2003-08-21 11:42:26	6	2	103	0	39	169	15	194.10	48	81.52	CHANGED	K++TAGt-LAcpVSEAKQsALLKHTKQQIK-MQLSLFDlAPWssohtAhPNDhuRSAlFTsRNKKlPR.ALQspsIaHVNKDVcITYTGlELRADDDELVatQVLEYAptTslGEPloFTFYELCQDLsWSINGRYYT+AEECLoRLQAoAMtFoSpRlG+LESVSLl+RFRVLDRGK+TSRCQV.IDtEIVVLFAGDHYTKFlWEKYRKLSPs.stRMFDYFuoH+EPYPLKLETFRLMCGSDSTRsKKWREQVGEAC-ELRtsGLVEpAWVNDDLVHCKR	......................................................................................................................s..hhRsslFs..........................................th.l.apG.pL......pt........la.....t.h..h.p...tpt..hs.....t.....h.h...s.hthhptlsht.......st...t.ht.h.tsltR..ht.s.th...t....h.....pt.t..t.t.......................hh.t........................p....t............t............h....h..ht.p.hh.hat.t.ho....h...ht.hR+Lo..P.s.....A..RR.h..F..DY...auoH...+..-.P...Y.PlKLETFRLMCGS-S.s..R.sKKWREQ.l.ucAC-EL+csG.L.V-s.AW....l.s..s...........................................................................................................................................	1	7	19	31
+6871	PF07043	DUF1328		Protein of unknown function (DUF1328)	Moxon SJ	anon	Pfam-B_12535 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 50 residues in length. The function of this family is unknown.	21.00	21.00	21.70	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.05	0.72	-3.97	105	1343	2009-01-15 18:05:59	2003-08-21 11:48:34	8	1	1124	0	357	687	48	39.40	58	70.82	CHANGED	llFhlIAllAulhGFuGlAuuAAuIAKILFalFLllhll	.....lIFLVIALIAAsLGFGGl.A.GsAAGhAKIlFhVhllLFlV..................	0	81	194	276
+6872	PF07044	DUF1329		Protein of unknown function (DUF1329)	Moxon SJ	anon	Pfam-B_12608 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica.	23.10	23.10	23.20	23.10	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.11	0.70	-5.52	104	761	2009-01-15 18:05:59	2003-08-21 11:53:27	6	4	350	2	275	746	454	269.20	22	78.32	CHANGED	sIoApN...hspYp..........cpLosGQhAhlKpYPs.a+hsVYsT+RosshPptlhcss+pNAspscLsss..Gsu.lp...shh.su..lPFP.l.....P..psGhEllWNahhRa+...Gt.shppthsphsspssGshs..hsphppphhhhhhh.stsstp..........sshhhhhh.phpuPu+luGsslLl+-slDp.htp.sRpAWhYssG....QRRVRRAPshAYDsPt.sus-GhtTsDshchFNGusDRY.-WKLlGK+..EhalPYNsYcl.........tsssh+as-llpssHlNP-hhRYELH...RVWVVEATLKsGtRHlYuKRsaYlDEDoWphs.hsDtYDs+GpLWRsspsah........h.hY-ssssh.ssspshaDLpuG.RYhs.shss...cpst.shph......s.ph.pp....spFossAL.Rp	...............................................................................................................................................................................sas.............ttu.......phh.p..h.t.......................h.....sGp...........t....thh......t.t......................tshh.hhh.hhptPscltGsshLshphhsp.....p.pptW.hY.su.....RRVRRhsshs..hcsPhhus.ssh.....hDsh..ph.apst.p.c..a.paphhGpp...hh............................................................php.+...csahlpup.p.....pch...as++hhalDp......Dsa.hh.hh-.YDtp.GpL..a+h..h..........h...p....h.h..h...th.hhhsl.st.+hhh.thtt....tt......h...........h.......t.apstsl.t...............................	0	91	161	228
+6873	PF07045	DUF1330		Protein of unknown function (DUF1330)	Moxon SJ	anon	Pfam-B_12466 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.76	0.72	-4.11	136	1006	2012-10-02 00:20:33	2003-08-21 11:56:04	6	4	649	38	383	984	2554	64.20	30	62.05	CHANGED	sptap.cYtptsssshtpaGGc.hLs+...uGphpslEG..hp.schVllcFPohcsApsaYpSs-YQ.tht	....................................ptat.pYtptsss.s.h.p.p..a..GG.c.....hl..s+....G...u..ph........csl...E...G.......t.sh...s+s..VllEFPohpsAhshYpSs-YQts......	0	92	214	298
+6874	PF07046	CRA_rpt		Cytoplasmic repetitive antigen (CRA) like repeat	Moxon SJ	anon	Pfam-B_12798 (release 10.0)	Repeat	This family consists of several repeats of around 42 residues in length. These repeated sequences are found in multiple copies in Trypanosoma cruzi antigens, Swiss:Q26907 contains 23 copies of this repeat.	21.40	21.40	22.60	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.60	0.72	-3.97	5	164	2009-01-15 18:05:59	2003-08-21 13:07:06	6	8	12	0	5	162	0	41.10	84	82.01	CHANGED	EAEKRKAAEAAKsAEAEKQRAAEATKVAEAEKQKAAEATKVA	.....EAEKQKAAEATKVAEAEKQKAAEATK..VAEAEKQKAAEATKVA.....	0	0	0	5
+6875	PF07047	OPA3		Optic atrophy 3 protein (OPA3)	Moxon SJ	anon	Pfam-B_12863 (release 10.0)	Family	This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity [1]. 	25.70	25.70	26.70	26.70	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.53	0.71	-4.38	19	343	2009-01-15 18:05:59	2003-08-21 13:16:55	7	6	247	0	243	347	2	139.30	29	65.35	CHANGED	PlhKLusLul+plSKPlAshlKppApps.hFRsh.......lhls.AQhhHhh-hphph+hhGh.tpss.......................................pIpPLNE-tAlplGu-LLGEhhIFs.....................VuuuhllhEapRpupp...-s+KEEthppclppLcpchpcLphtl.-phppp	...................................PhhKLssLhl+plSKPl.....A........st.l.....KppA+.........p.......p.h.F.Rph........h.lshAQhhH..........th-h+h+.h.th.hs..h..t.psh...........................................................................................pl.+PLsEppAl-h.........GAcllu.EhhlFs.....................VuuulllhE.hhRpppp....ptp+c..-....php....p....chppL...ppphpplt.t.p.....t.................................................................	0	76	126	198
+6876	PF07048	DUF1331		Protein of unknown function (DUF1331)	Moxon SJ	anon	Pfam-B_12865 (release 10.0)	Family	This family consists of several Circovirus proteins of around 35 residues in length. Members of this family are described as ORF-10 proteins and their function is unknown.	25.00	25.00	93.80	93.80	24.60	17.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.82	0.72	-4.49	3	11	2009-01-15 18:05:59	2003-08-21 13:19:41	6	1	6	0	0	8	0	35.00	96	95.77	CHANGED	MSTAQEGVLTVVALTVYPKVRERRVLKMPFFLLQR	MSTAQEGVLTVVALTVYPKVRERRVLKMPFFLLQR	0	0	0	0
+6879	PF07051	OCIA		Ovarian carcinoma immunoreactive antigen (OCIA)	Moxon SJ	anon	Pfam-B_13720 (release 10.0)	Family	This family consists of several ovarian carcinoma immunoreactive antigen  (OCIA) and related eukaryotic sequences. The function of this family is unknown [1,2].	25.00	25.00	25.70	26.20	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.38	0.72	-4.66	13	172	2009-01-15 18:05:59	2003-08-21 13:37:10	6	3	78	0	83	165	0	101.90	43	49.93	CHANGED	usu..ptsstpts.ptss.........tsuhsYhhop-Et+Vh+ECNcESFahRuLPlusluhllTtulVppGaLpsssRFGulPKVslAsllGYhlGKlSYhpsCtEKhhcL.NS.LG-	......................tt.s...........................huhtah.opEEp+lhpECpcESFWhRulPhussSMLlTQuLlpp.GhLuupP+aGSl.PKlhhAslhGYhsGKlSYhpsCQEKF.cpLc.N.S.LGp............................	0	20	28	45
+6880	PF07052	Hep_59		Hepatocellular carcinoma-associated antigen 59	Vella Briffa B	anon	Pfam-B_10544 (release 10.0)	Family	This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 and similar proteins. Family members are found in a variety of eukaryotes, mainly as hypothetical proteins.	22.70	22.70	23.10	23.10	19.00	18.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.47	0.72	-3.66	46	244	2009-09-14 11:59:59	2003-08-21 14:00:37	6	3	211	0	181	244	2	100.10	35	33.04	CHANGED	cpFs..spTspps.....Dp+M...hpYIEpcLt+........R+t..............ttppssstspstsp.ps..t.............Lhc.hPspLp.............tptt..ttphh..uuIsE...VDLGh-s....Kl+NIEcTEcA++cLh	.......................pFsscTspp-....cDtc...M........hcYIEsELtK...................R+shs..................tppp.pppsp.p.stpc.............tLac.lP-plc....................tppspp.hSsphh.....uGIsE...VDLGl-u......Kl+.NItpTEcAKtcL........................	0	62	94	139
+6882	PF07054	Pericardin_rpt		Pericardin like repeat	Moxon SJ	anon	Pfam-B_13724 (release 10.0)	Repeat	This family consists of several repeated sequences of around 34 residues in length. This repeat is found in multiple copies in the Drosophila pericardin and other extracellular matrix proteins.	21.20	21.20	22.50	21.20	20.00	20.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-7.95	0.72	-4.05	5	240	2009-01-15 18:05:59	2003-08-21 14:29:02	6	13	10	0	103	238	0	33.30	73	44.13	CHANGED	QPGYGSQPGVGuQTGAGQPGYGoQPGIGGQTGAG	.....QPGYG..oQPGl.G.GQ.T..G....u..G..QPGYG..oQPGlGGQoGhG....	1	40	40	83
+6883	PF07055	Eno-Rase_FAD_bd	scADH;	Enoyl reductase FAD binding domain	Vella Briffa B, Coggill P	anon	Pfam-B_10602 (release 10.0)	Family	This family carries the region of the enzyme trans-2-enoyl-CoA reductase, at the very C-terminus, that binds to FAD. The activity was characterised in Euglena where an unusual fatty acid synthesis path-way in mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The conserved region is seen as the motif FGFxxxxxDY [1].	25.00	25.00	27.10	33.60	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.93	0.72	-4.03	65	659	2012-10-10 17:06:42	2003-08-21 15:13:17	7	3	532	5	160	538	83	64.90	50	16.50	CHANGED	tlD-csRlRhDDhELcs-VQspVppLWsplTs-Nl.h-loDapGYKpEFLpLFGFsl-GVDY-ADV	......lDscsRlRhDDaELcsDlQpplpcLWsQlTs-Nl..ppLoDasGYKpEFlpLFGFsl-GVDY-ADV.............	0	41	82	120
+6884	PF07056	DUF1335		Protein of unknown function (DUF1335)	Vella Briffa B	anon	Pfam-B_10636 (release 10.0)	Family	This family represents a conserved region approximately 130 residues long within a number of proteins of unknown function that seem to be specific to the white spot syndrome virus (WSSV).	25.00	25.00	142.30	141.60	19.40	18.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.64	0.71	-4.41	5	17	2009-01-15 18:05:59	2003-08-21 15:24:03	6	2	2	0	0	12	0	128.90	46	28.59	CHANGED	DKsFpFSPLYRhIoc+LSsAsh+cc-phIVoTDFLlGLGFSscNVo+pLKuMEpsh.ppGhppohVPVsDICHRppYKGchIsNPIsuSaSspCLIVPLshLGtlFSpssaPSutsl-sYhusLssAVllY	.DKsFpFSPLYRhlpcpLSpAsh+cp-hhIloTDFLlGhGaospsVs+pL+sMEphh.ppshtpohVsVh-ICHRhpYKGthIsNPIhtSaSspCLIVPlshLGhlFupssaPSutslcsYhusLh.AlllY	0	0	0	0
+6885	PF07057	TraI		DNA helicase TraI	Vella Briffa B	anon	Pfam-B_10638 (release 10.0)	Family	This family represents a conserved region approximately 130 residues long within the bacterial DNA helicase TraI (EC:3.6.1.-). TraI is a bifunctional protein that catalyses the unwinding of duplex DNA as well as acts as a sequence-specific DNA trans-esterase, providing the site- and strand-specific nick required to initiate DNA transfer [1].	20.60	20.60	20.60	22.90	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.45	0.71	-4.13	8	282	2009-01-15 18:05:59	2003-08-21 15:48:57	6	11	224	2	13	255	4	121.40	78	9.48	CHANGED	VuLSRhKpHVQVYTDN+psWssAlsp..usptuTAHDlLEP+sDRpVtsAsRLhuTAppLccTAhGRAVL+puGLtpspohA+FIuPG+KYPpPaVALPsaD+NGKpAGlhLssLsscDss.hRsltGE	...VALSRMKQHVQVYTDNRQGWTD.AINN..AVQKGTAHDVhEPKsDREVMNA-RLFSTARELRDVAAGRAVLRQAGLAGGDSPARFIAPGRKYPQPYVALPAFDRNGKSAGIWLNPLTTDDGNGLRGFSGE............	0	1	1	9
+6886	PF07058	Myosin_HC-like		Myosin II heavy chain-like	Vella Briffa B	anon	Pfam-B_10658 (release 10.0)	Family	This family represents a conserved region within a number of myosin II heavy chain-like proteins that seem to be specific to Arabidopsis thaliana.	19.60	19.60	37.30	20.70	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.01	0.70	-5.36	3	95	2009-01-15 18:05:59	2003-08-21 15:55:57	6	5	21	0	62	100	1	292.60	55	56.63	CHANGED	MVDDLQNKNQELMKQIEICQEENKILDKMHRQKVAEVEKLoQSVRELEEAVLAGGAAANAVRDYQRKFQEMNEERKTLERELARAKVoANRVATVVANEWKDuNDKVMPVKQWLEERRFLQGEMQQLRDKLAIoDRAAKSEAQLKEKFpLRLKVLEEoLKGPoSSuoRsTo.uRSpSNGPoRRQSLGGAEs..KFTSNGuLSKKsPSSQLRtSLTusuooVLKHAKGTS+SFDGGTRSlDRSKlLlNGP.uNasLNcKuoEsopcuE.....p.sSE+KsEpEDscAsoEDSVPGVLYDLLQKEVIoLRKAucEKDQSL+DKDEAIEMLAKKVETLTKAMEVEAKKMRREVAAMEKE	...........................hVDDlQN+NQELhKQIEICQEENKILDKhHRQKVuEVEKLoQTV+ELEEAVLAGGAAANAVRDYQRphpEhNEE++TL-RELARAKVoANRVAs.VVAN..EWKDsNDK.......VM....PVKQWLEE...RRh..............LQGEMQpLRDKLAluERsA+uEAQLK...........-KhpLRLKVLE-uL+ssss.s.s.sps.....s......s+o.....s.........su...s.RR....pS.......lGus...-shsph.s.N..Ghh.++ps..s.p.RsSl.s....sss.....l.l..+.puc.........t..s..S.....+ShDG...u..s+ul-.......p.t....K.hh..hsG..............h.....h.p.........p.tsctspttp................................p.ssp.p.t.....p.....phss....s.....pspD.VsGhLYDhLQKEVlsLRKusc-KDpoL+DKD-AIEMLuKKV-TLTKAMEVEuKKhRRElAuhEKE..............................................................................	0	14	40	51
+6887	PF07059	DUF1336		Protein of unknown function (DUF1336)	Vella Briffa B	anon	Pfam-B_10173 (release 10.0)	Family	This family represents the C-terminus (approximately 250 residues) of a number of hypothetical plant proteins of unknown function.	20.70	20.70	22.70	21.00	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.49	0.70	-4.94	20	403	2009-09-14 23:05:42	2003-08-21 16:08:14	7	20	43	0	274	397	12	194.50	33	37.25	CHANGED	Wo.ssssssFplRGcoYhp.DKpKhPAssh.hhp.lGlDhFpusc.+............hccIupphst.stpstpp...tls.......alhllNlQlPs..............u-shSlVlY.....Fthpcshpc.........tsLlcRFlctD.....DuF+.......ppRlKllssllp.G....sWhl+psV..hspKPsLlGptsppsah....cGsN......YhEIDlDlus.ShlA+sllchhhuhlsslllDluhhIQupstEELPEplLsslRLNcl-	....................................Ws..sssssFhlR.GpsYhp.....c...........+p..............Khs.usp..hhp.lusDhhpssp...+..................................hcclstp.........t........s...thhtp................th.........hhhllNlQ.l.Ps...............................spthShVhY.............ahhpp.h.t.........................pllp+Flp..sD........csF+..............................spRhKllst..lsp.u............................shhl+.phV....sppssLl.s.p..thp.pp.ah............pGss........................Yh.ElDlDlts..ShlAptsl.phhhs.hlpslslDhuhllpu...ppt-ELPEp..lLGssRlspl-........................	1	101	204	245
+6889	PF07061	Swi5	DUF1337; 	Swi5	Wood V, Studholme DJ	anon	Wood V	Family	Swi5 is involved in meiotic DNA repair synthesis and meiotic joint molecule formation [1][2][3].  It is known to interact with Swi2, Rhp51 and Swi6 [1].	20.60	20.60	20.90	32.70	20.50	18.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.87	0.72	-4.20	20	177	2009-01-15 18:05:59	2003-08-21 16:39:21	6	8	155	0	119	162	1	83.60	31	40.18	CHANGED	phpshpsphssLcp.pht.....phcpplu-hpup............psPpppVc+HI+LLHEYN-lKDlGQtLlGhIADtRGl+tt-lacEaGlshs-	................................................................p.......phtplcp.p.t............thpp..plpph.tsc..............................t..tstptlccHIphLHEYN-lKDlGQtLlGhlA.sh+GVphp-lap-..aslshp....................	0	39	62	92
+6890	PF07062	Clc-like		Clc-like	Vella Briffa B	anon	Pfam-B_11218 (release 10.0)	Family	This family contains a number of Clc-like proteins that are approximately 250 residues long.	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.46	0.70	-5.08	5	78	2012-10-03 00:20:40	2003-08-21 16:52:45	7	3	13	0	70	76	0	179.30	26	62.97	CHANGED	plllhsSLlLolVuhsLouAAlhTPSWQVVDlREaRuhHQHGLWLDCsRtpp...Hllp..s.hs-sPLHCsYKFDhDuh.sYppsl-shD....psussGEsc+HpFaGWH+ulLhlhlhShlhAuLSlhSGlCAsCssupA....lhaoIhlslAuLluslu-uIFFlsAaRVDsRFl.pGlVGTYEQ+lGYAFYLplsGshlallAllhAsLsoYhoFlsuc	.........................................t....hhshlhhlluhhL.hhuhhoPuWQ.l....sphp-hpt..hppGLWhsChp..p...................................t..........hpChY+Fs....ss...ht....t..c..............tssttsc.p.pcpF........a.....s.W+huslhhhhhuhh..huhlul...hh...uhCu.sh.shu....lhhslhh.hhsslhuhhu.hlFhhhuph....h.......-s+al....uhsspYE......pc..hGhuaYlthhush.h.hhuhlhuhhhsh......p...................	0	26	34	69
+6891	PF07063	DUF1338		Domain of unknown function (DUF1338)	Vella Briffa B, Bateman A	anon	Pfam-B_10864 (release 10.0)	Domain	This domain is found in a variety of bacterial and fungal hypothetical proteins of unknown function. The structure of this domain has been solved by structural genomics. The structure implies a zinc-binding function, so it is a putative metal hydrolase (information derived from TOPSAN for PDB:3iuz).	20.90	20.90	22.30	21.60	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.84	0.70	-5.36	94	1224	2009-11-20 14:21:51	2003-08-21 16:56:52	8	5	1137	6	261	849	170	336.20	41	87.14	CHANGED	tpphhpuL.phYhp.csPpstslh.cLlsp....sspplhp..........................DHhAlRoh........sssshslssls+hFtshGatssGh........Ych.sstp...lpuptFc.s...............csst........s+lFlScLcl-plo...sphpphlppll..........hsttshphl............pth.........................thlsthLts..................hpW..pt...sshssYppLtpESchsAWlss.pGhphNHhTspl.............................-Icplppthpp.....pGhshp....ut............................................................................................lcGsPp.....hhLcQoShhA.p.slpF............t-s.....sptphsusFhEhtpR....................................................................................................st........t....p.hha-sFlssSAstIFcSTh	................................................................ppFupAhSsMYppE.VPpYuTLl.-LVuc.......lNhsllptp.thtt..................sthtRls.ERHGAIR..........lGostELusLpRhFAhhGMhPVuY........YDL.spAus...PV+STAFRPl...............DsssLth.....sPFRV.FT.ShL+lEh...lp..pttLRppstclL.....tpRplFospshpLl............cph-tp.............GG.hsttpAppFltps.Lcs..................F+W..cpps.VsppsYcsLppEpclhADVlsh.GsH.INHLTPRs............................LDIDpVpshMsc.....pGlp.K.....sh............................................................................................IEGPPcpp.sslLLRQTSF+ALcEsVhF.............ssp.......hpGshsuRFGElEpRGhALT.cGRthY-thht...........................................................................h.........t......tshsps........hhttGhh.tpPlsYEDFLPsSAAGIFpSNL..........................................................................	0	52	116	189
+6892	PF07064	RIC1	DUF1339; 	RIC1	Vella Briffa B, Wood V	anon	Pfam-B_11581 (release 10.0)	Family	RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network.  It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor [1].	20.90	20.90	24.10	22.50	18.40	16.50	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.61	0.70	-4.94	21	304	2009-01-15 18:05:59	2003-08-21 17:06:16	8	12	258	0	221	323	0	244.90	30	21.67	CHANGED	sLc-uLWhasG.pthp.........sWhsh.s.......t......tp.....lsc.l.ls..l-hYPLulLhsculllGsps-hh............pppsssashhchphcoplaL..lLpthL...........hps...........hstpAhplspphppLsYFsHsLElLLHpVL--Esss..............s.psslLPsVluFLpp...aPpaL-lVVpCsRKTElppWphLFshlGsPp-LFccCLppppLcTAuuYLllL...................pshE.stus......spppsl+LlphAlcppcW-Lst-LsRFLtulDsststh.p	...............................................................................................................l.psLWh.tG.tthh................lWh.sh.............................t.t..p................h..t.l.ls....hphYPLulLhppu..l..llGspschh................................php...hth.....shhphphp.o....plaLpplLcphL....................tps...........hs.pAltlu...pp...h.....p.p..LsaF.sHsLElLL.H.p.VL--.Esssp..................................................................sh.cslL...splhphlpp................F.s...a............LclVVpCsRKTE....hthWp.h.LFs.hl.u.s.Pp...-LFE.......cCLp.tppLc.TAuuYLllL............................................pshE...ssss..............sp...ppus.pLlpt....A........hp.......p........sc........W-Lst-LhRFLtulspstp....p....................................	1	73	119	183
+6893	PF07065	D123		D123	Vella Briffa B	anon	Pfam-B_10915 (release 10.0)	Family	This family contains a number of eukaryotic D123 proteins approximately 330 residues long. It has been shown that mutated variants of D123 exhibit temperature-dependent differences in their degradation rate [1]. D123 proteins are regulators of eIF2, the central regulator of  translational initiation [2].	19.30	19.30	19.30	19.30	18.70	18.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-12.13	0.70	-5.34	23	384	2009-01-15 18:05:59	2003-08-26 10:47:36	9	6	285	0	263	392	8	253.20	27	73.76	CHANGED	WYsh...F+ph.Th+ohlI.PLPc..shlcYLtpDG..lhlspppss...........psssssphs-..pt.sDspstp..........ssscFPEhp..pplp-AIppLGGtVhPKLNWSAP+DApWIsssso...lpCpsssDlaLLLKuS-alsHDLsc..satt.s.D............cpsttt........saELVLRcWh.clpPuhEFRCFV......KspcLluloQRDh.sYY-aL..tc....c-plpstIppFa....c-pl...h.pF....sscsaVhDVYlsp.....s+lhlIDhNPauc.pTDsLLFoWsELpshtt..........ptpsp.-hRll..........sstsphts.ppasp.plPhDhl-sops	....................................................................................................................................................W......att..s.pshhl..ls......thhpYL.tDs..hhls...t.........................................pttt.p..p....t...tppttt.................................pas-h......p..tplppsI.pp...hG...Gt.......V....hPKLNWSuP+DAhWh....s.so.......................hpCpshs-laLLL+uSs.hls+DL..pp...satt.s.s...................................................t....h..............th.LlLRcah..sl..p..PuhEFRCFV................+pppLl.uloQR-h...p...aa....s.al....t...........ppplhptIpp...Fa.................pppl...........t..pa.......psalhDl.Yhsp......................t+lhllDhNPau...h....T..csLLFsWpE.l.t.t........................................................h.ph...........................................s.............................................................................	1	101	163	227
+6894	PF07066	DUF3882	Phage_Lacto_M3;	Lactococcus phage M3 protein	Moxon SJ	anon	Pfam-B_13997 (release 10.0)	Family	This family consists of several Lactococcus phage middle-3 (M3) proteins of around 160 residues in length. The function of this family is unknown.	22.10	22.10	22.20	22.30	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.10	0.71	-4.38	2	63	2012-10-03 01:22:09	2003-08-26 11:41:59	6	1	61	0	2	51	62	148.30	62	96.44	CHANGED	MpKhLAIDFSTus.....TGYAFRp..ssphhVGSI.Ahs.pKsshERsh.IssuIp-lI-casLhsYalhIEpPIhshppKtsIoLhpsNG.FlGshcshhN.GYs.lsNSKWCuYHLIpGKpt.RK.pSlElLKuhslVssNshsDshADAasILhYsEp	.............................MSKALAIDFSTSN.....TGYAFRNP.LTNE..YVV.GSI.A.GGKSKDPL.E.RAKlIADGITEl....IEHYNLFD...YF.....IYIE.E.PIITFKSKGNISLIRANGSF.LGV..M.RNR...HN.IGYVDls.NSKWCGYHL...IKG.KSthRKs...QS.IE.IL.KS.a.sIVP..cc.....cIN.DD.ADAFCILLYVES..................................................................	0	1	2	2
+6895	PF07067	DUF1340		Protein of unknown function (DUF1340)	Moxon SJ	anon	Pfam-B_14083 (release 10.0)	Family	This family consists of several hypothetical Streptococcus thermophilus bacteriophage proteins of around 235 residues in length. The function of this family is unknown.	25.00	25.00	263.00	262.80	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.42	0.70	-5.20	3	13	2009-01-15 18:05:59	2003-08-26 11:44:03	6	1	13	0	0	14	0	235.10	71	100.00	CHANGED	MSGKYcYAGLTKELHQRLVlEFsALKEcHsRTFTKHIMETKQCNRppARKYFQRFDNVIKERSKLSPuTLDDMREYLT-GLVNDLQEYLSEHYSAsSsSCKPDTsKTNAGLTEELF+QYRcEIcsLRAAHPNsFAsYIMEVKGCSpQQA+TIpTAINTIYTEIGILTPRKVIQLEGLLSRELFGKIAKYVFNKYEWPESLDSEVDRIYLEYRTKGDLGLEKESVKRALYKAIYMGL	.MK.+YEYAGLTKELHQRLTlEFDAL+EcH+R.TLTKYIMETKpCsRhpARKYFQRFDNVlKERSKLSPuTLDDMREYLTDGLsNDLQEYL.KpYosRsspC+PDsDKsNAGLscELFhQYRcEIppLRAsHPNshssYIM-VKGCopQpAsoIpTAINTlYTElGILTPRKVIQLEGLLSRELFGKIAKYVFNKYEWPESLDSEVDRIYLEYRTKG-LGp-KESVKRsLYKAIuMGL	0	0	0	0
+6896	PF07068	Gp23		Major capsid protein Gp23	Vella Briffa B	anon	Pfam-B_12245 (release 10.0)	Family	This family contains a number of major capsid Gp23 proteins approximately 500 residues long, from T4-like bacteriophages.	19.20	19.20	20.40	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	493	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.80	0.70	-5.97	4	1586	2009-01-15 18:05:59	2003-08-26 11:48:55	6	2	183	1	0	1357	2718	119.50	36	80.33	CHANGED	Ll-KWKELLEGEG..LPEIAN.SKQAIIAKIFENQEKDFpsuPEYKD-KIAQAFGSFLTEAEIGGDHGYsApNIAAGQTSGAVTQIGPuVMGMVRRAIPNLIAFDICGVQPMNSPTGQVFALRAVYGKDPlAAsAKEAFHPMYuPDAMFSGQGAA.KtFsslsAostTssGDIYp.HFFpETGosY...LQAohtVTIsutAssuthhDAEIhKQMEAGsLVEIAEGMATSIAELQEGFNGSTDNPWNEMGFRIDKQVIEAKSRQLKAAYSIELAQDLRAVHGMDADAELSGILATEIMLEINREVVDWINYSAQVGKSGMTphsGSKAGVFDFQDPIDIRGARWAGESFKALLFQIDKEAVEIARQTGRGEGNFIIASRNVVNVLASVDTGISYAAQGLAoG.FsTDTTKSVFAGVLGGKYRVYIDQYAKQDYFTVGYKGuNEMDAGIYYAPYVALTPLRGSDPKNFQPVMGFKTRYGIGVNPFAESohQAPuuRIQSGMP	........................................................................................................................tt.........................................................................................................................................................................................................................................................................................................................................................................................................................................th.......s........s....s....s..s...s.a.....scMuFoI-KhoVsA+oRAL.KAEYohE..LAQDLKAlHGLDA.EsELuNILo................................................................................................................................................................................................................................................................................................................................................................................................	2	0	0	0
+6897	PF07069	PRRSV_2b		Porcine reproductive and respiratory syndrome virus 2b 	Moxon SJ	anon	Pfam-B_13261 (release 10.0)	Family	This family consists of several Porcine reproductive and respiratory syndrome virus (PRRSV) ORF2b proteins. The function of this family is unknown however it is known that large amounts of 2b protein are present in the virion and it is thought that this protein may be an integral component of the virion [1].	25.00	25.00	113.80	113.70	22.30	22.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.60	0.72	-3.69	2	55	2009-01-15 18:05:59	2003-08-26 11:57:46	6	1	6	0	0	55	0	72.30	84	100.00	CHANGED	MGSMQSLFDKIGQLFVDAFTEFLVSIVDIIIFLAILhGFTIAGWLVVFCI+LVCSAlLRsRPslHsEQLQKI.	.MGuMQSLF-KIGQLFVDAFTEFLVSIVDIIIFLAILFGFTIAGWLVVFCIRLVCSAlLRuRsAlHsEQLQKIL.	0	0	0	0
+6898	PF07070	Spo0M		SpoOM protein	Moxon SJ	anon	Pfam-B_13263 (release 10.0)	Family	This family consists of several bacterial SpoOM proteins which are thought to control sporulation in Bacillus subtilis.Spo0M exerts certain negative effects on sporulation and its gene expression is controlled by sigmaH [1].	20.40	20.40	20.50	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.36	0.70	-5.00	9	513	2012-10-02 22:29:00	2003-08-26 12:03:17	6	1	383	0	138	438	6	209.40	36	81.77	CHANGED	FKKhLAShGIGuAKVDTlLppsslhPGtslpGpV+lhGGsssQ-I-pIpLcLss+Y.s.EscDsc...........sppshshspaplstuFsIpsGEc+shPFslslPapTPlTh.....t.chpVhlcTsLDIAtAlDssDhDhlsVcPpPhh-ulLpAl-pLGh+l+ps-sEps+h...GtpLPFVQEhEasPs.G.Y+t.hcElEllFhtssssL-llhElD++tpG.pGhLu-	.......................hKKhLAShGlGuApVDTlLpp.....tshhsGpplpGpl+lpGGsssQ.pI-pIplpLssphhh..E.s..s..Dpc.....................ht.p.s.hsltphplst.s.FslpsuE.p+plPFphplPh-.TPlTh.......s.ttpValcTsL...DIstAl.DPsDcDhlpVpP.PhhpsllpAlp.p.LGF+h+p..s-sEpu.h....htpp.l.P.F.hQEhEFhPs.utatGthcElElshl...h.s.s.c.tlc.llhElDR+......sGhh.....................	0	31	86	118
+6899	PF07071	DUF1341		Protein of unknown function (DUF1341)	Moxon SJ	anon	Pfam-B_14024 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 220 residues in length. The function of this family is unknown.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.50	0.70	-4.81	13	679	2012-10-03 05:58:16	2003-08-26 12:09:50	6	3	511	18	56	391	4	207.80	59	88.40	CHANGED	Y+sRVCLNVLAuSl-NAc-IY-AAEGHVLlGVLSKNYsoV-sAlsDM+cYsphl-NAlSVGL.GAGDPpQStMVucIScplQPQHlNQVFTGVGsSRALL...GQs-TllNGLVSPTGpsGhVcISTGPlSSp.ptcuIVPlETAIAhL+DMGGoSlKFFPMGGLppc-EYpAVAc.ACAccuFaL.EPTGGIDL-NFEpIlpIAL-AGVc+VIPHlYSSIIDpt	..................................................................Y+sRVsLNVLAtshpNA+-IY-AAEGHlllGVLSKsYsoV-pAVs-MKcYtAtls.u.lSVG.L.GAGDPsQ.thVucIutphpPpHVNQVFTGsG...h..oRuhL....Gtp-T..hlNuLVSPTGpsGhVpISTGPhSSp..ussuhVslETAIthlpDMGusSlKaFPMsGLpph-EapAVAp.ACA+psFhL.EPTGGIDL-NFtpILp...IAL-AGVp+lIPHlYSSIIDp.................	1	9	21	39
+6900	PF07072	DUF1342		Protein of unknown function (DUF1342)	Moxon SJ	anon	Pfam-B_14075 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 250 residues in length. Members of this family are often known as YacF after the Escherichia coli protein Swiss:P36680. The function of this family is unknown.	20.80	20.80	21.10	23.50	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.19	0.70	-4.68	63	930	2009-01-15 18:05:59	2003-08-26 12:13:27	6	1	924	2	168	466	123	206.70	50	83.59	CHANGED	LRLEtLhpplpthhstsct..hppchshpsLF-ll-lh-RsDl+o-LlK-LE+QpppLpsapshPslDpptLppllpclcpstssLhsss.+hGptL+-scaLsulRQRhuIPGGsCsFDLPuhHhWLpps.cpRpp-lppWhssltPLtpulsllLcLlRpouphpp.hApsGhaQpsh..pu...pLLRlcls.s..shaPpISGpKhthuIR	..............LRlEaLlpQLshslshsDp..ssslpFFRsl.-LLDVhE.Ru-.lRoELLKEL-RQppcLp.sWhsVPGVDQspl-uLlppLcssuusLhoAP.RlG.QhLREDRlluhVRQRLSIPGGCCSFDLPoLHhWLH.L.P.psQRcsplpsWluoLsPLspALohlLcLIRpSusFR.+Q.suhNGFYQcNus.-A...cLLRLpLsL..-..pplYPpISGHKsRFAIR......................	0	29	82	126
+6901	PF07073	ROF		Modulator of Rho-dependent transcription termination (ROF)	Moxon SJ	anon	Pfam-B_13280 (release 10.0)	Family	This family consists of several bacterial modulator of Rho-dependent transcription termination (ROF) proteins. ROF binds transcription termination factor Rho and inhibits Rho-dependent termination in vivo [1]. 	20.80	20.80	20.90	22.10	19.50	20.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.46	0.72	-3.97	31	733	2009-09-11 04:47:18	2003-08-26 12:43:39	7	1	727	1	80	248	6	74.20	59	89.79	CHANGED	.IsCcpYDYlElACh++h.lpLpL+sG-plpGpAh-htppt.....cKpEaLh.....................lcpp.uspptlcLDpIsuhsshp.sPcFuplhl	..PINCDDYDsLELAC.HHLhLTLpLKD...G.EpLQAK...AsDLlpR......KNVEYLl.....................lEs.u.....GEopELRLDKIsSFS....HPEIGTVVV.......................	1	9	26	52
+6902	PF07074	TRAP-gamma		Translocon-associated protein, gamma subunit (TRAP-gamma)	Moxon SJ	anon	Pfam-B_13437 (release 10.0)	Family	This family consists of several eukaryotic translocon-associated protein, gamma subunit (TRAP-gamma) sequences. The translocation site (translocon), at which nascent polypeptides pass through the endoplasmic reticulum membrane, contains a component previously called 'signal sequence receptor' that is now renamed as 'translocon-associated protein' (TRAP). The TRAP complex is comprised of four membrane proteins alpha, beta, gamma and delta which are present in a stoichiometric relation, and are genuine neighbours in intact microsomes.  The gamma subunit is predicted to span the membrane four times [1]. 	21.00	21.00	21.40	21.80	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.04	0.71	-4.73	9	147	2009-01-15 18:05:59	2003-08-26 12:49:58	7	3	109	0	80	132	1	154.60	62	87.79	CHANGED	EEELLLQDFSRNVSTKSSALFYGNAFIVSAIPIWLFWRlHpM-lhsShllFslhThsSTaLlAhAYKNsKF.LKHKIAh+RE-AVoREVspcL..uDDKKhoRKEKDERILWKKNEVADYEATTFSIFYNNALFLslllhuSFalL+ohsPohNYllShusAuGLlALLSTG	...................EE-LLLQDFSRNlSsK..SoALFa.GNAhIV.SAlPIWLaWRIapMDLh...p..S.ullaslhTLlSTYLlAFAYKNlKFlLKHKlAtKREDAVo+EVoRKL...ADs+K.MSR.KEKDE.............R...............ILWKKNEVADYEATTFSIFYNNsLFLslVIluSFFlLKNFsPsVNYIlSlusuSGllALLSTu................	0	30	36	60
+6903	PF07075	DUF1343		Protein of unknown function (DUF1343)	Moxon SJ	anon	Pfam-B_13635 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 400 residues in length. The function of this family is unknown.	25.00	25.00	25.10	25.00	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.30	0.70	-5.61	109	613	2009-01-15 18:05:59	2003-08-26 12:52:12	6	11	514	0	245	629	524	355.00	36	82.47	CHANGED	VGLlsNpouls................t............shpp.........................slDhLhpt.sl...plptlFuPEHGh+Gs...spAGt.plssshDscTGlPlhSLY...................Gps...+.......................+PosphLc..s......lDlllFDIQDVGsRaYTYIsThthsMEAs.....................................uctshphlVLDRPNPhsGthl-GPlL-.ta............cSFVGhaP.lPhtHGhTlGELAphhsschhl....................................s....scLpVlshcsWpR.........shhasp.ssh.al.PSPNhPssposhlYPuhslhEG.T...........slStGRGTspPFp....lhGAPa..lc.s......tlhtthpt.t...l.GshapshtFpPp......hp+..apGchCtGlplp.l......s.pthcshpsuhhhlphlpc.hY............spphth.t..........th.......h.h-hLsGsspl+ptI.........ps.Gtshcc....ItppappclppFpphRpp.YLL..Y	...................lGLloN.Tuls.................p....p.h.pp.......................hl.DhL.hp....p......sl.....plsslFuPEHGhRGs..............spAGt...plss.thDs...p..TGlPlhSLY......................Gcs...+...........................+PsschLp..s........lDlllFDIQDVGsRaYTYIsThthsMEAs.....................................Ac..tsh.....p......hlVLDRPNP.sG..t..h..l-GPl.L.-..pa............pSFVGhhs.lPhhHGhTlGELAphhNsE.hhl..............................................................s....scLpVlshp.........sWpR.............sh.hast.tth..a....l.PSPNlPs.poshlYPuhsl.hEG..T...........sl.S.GRGTshPFp....llGAPh..lc...s.............thhtth.pt.t............lsGhtF.ps.htFpPt.........hs+....apuphCtGlplp.l...........s.pthp.s.h.c.hsh.h.hlphltc...hY..............spphtht....................th........thhDhLsGssplRptl.........pt..Gtsh..pc....lpptWppslppFpp.hRppYLLY......................................................................	0	119	188	224
+6904	PF07076	DUF1344		Protein of unknown function (DUF1344)	Moxon SJ	anon	Pfam-B_13761 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of around 80 residues in length. Members of this family are found in Rhizobium, Agrobacterium and Brucella species. The function of this family is unknown.	23.10	23.10	23.10	24.90	23.00	23.00	hmmbuild  --amino -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.68	0.72	-4.40	9	104	2009-01-15 18:05:59	2003-08-26 12:55:15	6	1	91	0	25	57	3	61.00	56	67.66	CHANGED	.As-sEGpIpplDpcuholTLDDGKTYpLPtEhch-uLcsGhKVlVhYspss.GcphlsDlp	....hApDsEGpITcIsKDocTITLDDGcTYKLPuEFD...luAlsPGMKVLIhYDlVD.tpRhITDIQ..................	0	1	11	14
+6905	PF07077	DUF1345		Protein of unknown function (DUF1345)	Moxon SJ	anon	Pfam-B_13768 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 230 residues in length. The function of this family is unknown.	24.00	24.00	24.10	24.20	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.08	0.71	-4.76	56	475	2009-01-15 18:05:59	2003-08-26 12:57:27	6	1	441	0	171	432	34	171.60	32	81.43	CHANGED	hshshs..hstplLlGWsssshlYLslshhhhhp.tsspclRcpApppDcstsllhhlsslus.......huSlsAIshtLssu+p.t...spshchslshsolhhoWhhlpshFulHYA+hYY...........ttstptsGLpFP...s............pppPcYaDFlYFSFsIGhTsQsSDVslso+phRRlsLhHullSFhFNoslLAl	..............................................................................hh....t..hthlluWsshhhlYLlhhhhhhhp.h.ss.ppl+phAtppDpst...hhlhhlshhAs.......lsSlsulhh.Ls...ssp..p.......sphhphslshh...olhhu.WhhltshFulHYA+hYY...........ttstttsuLpFP....t..................ptpPsYhDFlYFSasluh...ssQToDVslsopphR+ssLhpullSFhFNssllAh...................	0	40	93	132
+6906	PF07078	FYTT	DUF1346; 	Forty-two-three protein	Moxon SJ	anon	Pfam-B_13991 (release 10.0)	Family	This family consists of several mammalian proteins of around 320 residues in length called 40-2-3 proteins. The function of this family is unknown.	19.50	19.50	20.00	20.50	18.50	19.40	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.09	0.70	-5.12	2	70	2009-09-14 11:59:21	2003-08-26 13:00:14	6	4	40	0	32	87	0	230.00	53	92.94	CHANGED	RFuTRLhGATATPPP.PPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLQQSusRQFRMRVRWGIQQNSGFGKsSLSRRGRVhPGKRRPYGVITGLAARKATGIRKGISPMNRPPLSDKNIERYFPALKRKssLLRQNEVQRK.VAsLKRPNQLNRKNNIPsNFTRsGNKLSHQKDTRQATFLFRRGLKVQsQLNoEQLlDDVVAKRTRQWRTSTTNGGILTVSIDNPGAVQCPVTQKPRLTRTAVPSFLTKR-QSDlKKVPKGVPLQFDINSVGKQTGMTLNERFGILKEQRAsLTFsKGGSRFVTVG	...................................................................thshoLDDIIKLN+KE...t..p......+.........p.phsp..hp..R+.h.ppss....sp.......php...h.R.s.RW.GlQQ.pu.G.h..G+..stl.s..R....Rs+h..hP...GKRRs.GVITGLAARK.ssul+KGlSPhNRsPLSc.K.....shp..p.h....PhlpR...pss..R...ps-hQR...+............hs.lp+stthpR.p...............h....R.s........h..ptQ+-sR..QApFLF+R.G........LK.VQsQlp.tphhs...ss.pR...TRQW..RoSsssuGILTVSIDNPsAhp.....p..P.s.+s.RL...sRsshPsFlhK+-ps-.K.KlPKGVPLQFDI..NSVGK.QTuMTLNERFtILK-QRsshs..s+.GSRFVTVG................................	0	1	3	14
+6907	PF07079	DUF1347		Protein of unknown function (DUF1347)	Moxon SJ	anon	Pfam-B_14317 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 610 residues in length. Members of this family are highly conserved and seem to be specific to Chlamydia species. The function of this family is unknown.	24.00	24.00	24.30	75.50	23.30	23.90	hmmbuild  -o /dev/null HMM SEED	550	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-12.73	0.70	-6.30	6	40	2009-09-14 11:58:54	2003-08-26 13:26:39	6	2	37	0	7	25	0	547.60	57	85.61	CHANGED	spQQ+.tLLCFQGFlLQKQ+phpQSEcIFSKIYcEhpsu.FlhKEElLGGRILNAFFL-NI-hM-hllspLcQpsupSsYLsLFcsLlsYKQKpacpAlpsLShWpsplcpocssLLDlNIppLhSDFlL-sIpAHSLIEhGcFuEGRsILNRIIcKlLKREssWsu-sYDphVLMLSRSYFLELppSppscIYPDYYEMILFYpKKl+ulDQpuYccFlPp-ELhShlM-HlFVVPc-+LsPLMQllchWE+aYhsPNYsLVlcsLlc+Fhosspplt+lCpuIss.c.IEpLKc+LI-sFuclLStpVpplpTscApQsLuLLKILDsslShSEKLllSscsLpcIlupDDtpaTpL+cYLsLWEpIQSYDlDRQQLVHYLhhuAKpLW+pGssD-KALNLL+LILpFTsYDIECENlVhLFlKQsY+QsLStHuhsRLLKLEDFIo-sGLTsIsluEtEIANFLADAEaLaupG-Y+KCYlYShWLTKlAPSs.sYRLLGLCLhENKpYpEAW-hLppLP.NcchaDSKVQKALlLCQKHlsKDhtso	........pQpphYlLCsQGFoLQhQ+KFQESEcIFSRIaccpsSuPFlLpcELLpGRILNAYFLNNLsLMscplsELE+hsG.spsaLhhFKALaAY+sKpYchAl-sLSpWhu+VcpTcshhLDTNl.cLFSsalLEcIuA-SLIts+RauEGRlllNplhNKlFsREasWssDhYNRlVLMLGpSYLLELpEuspuDLhP-YYEhILFYpKph+uhDttAYcpFhPEs.LVsTIMQHlFVlPEspLPhaMphLhMW.ENpYVHPcYSLVlEphcstllp.Du.csp+ICpAIAcS.K.Ic+LKE+LI-hFu-.LshsVpQspTlpAcQYLALLKhLDPcsS.hu+KL..LLSpKplhNhVCpDDuQYo+LKDYLhLWEEt-.tDVDRQQLVHYLhauAK+LW+tGQ.-EtsLcLLKtILhFopp-h..tC.NpshchVKahYsQALuh+shT+LlhlENFl-EVGLPphlsS-AE.IANpLADApYLFu+GDY+hChlYSSWLs+VAP.SscAhpLLGLsLhEpK-YsEALEshpcLP..sE-hasSpVpKA.lLC.Kalu+ppcpp...............	0	1	2	6
+6908	PF07080	DUF1348		Protein of unknown function (DUF1348)	Moxon SJ	anon	Pfam-B_14137 (release 10.0)	Family	This family consists of several highly conserved hypothetical proteins of around 150 residues in length. The function of this family is unknown.	21.10	21.10	21.70	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.74	0.71	-4.39	7	617	2012-10-03 02:27:23	2003-08-26 13:50:36	6	5	563	4	278	595	44	138.20	62	88.57	CHANGED	RPPLPPFTtETAhpKVRhAEDuWNSRDPs+VuLAYTpDShWRNRuEFhpGR-tI.tFLoRKWp+Eh-YRLIKELWAFsGNRIAVRFtYEW+DDuGpWaRSYGNENWEFDEpGLMp+RcASINDlPIuEu-R+a+W.sLGcRPsD	................................RPPlPPF.T.t.EoAhpKVRhAE.DuWNoRDPp+VuLAYTsDSt.W.R....NRuEF.lsGRpcIhsFLpRKWp+El-YRLIKELWAFs..sNR.............IAVRFAYE.W....H......D...D.u.G....p.WFRSYGNENWEFs.c.s....GLMp+RaASINDlPIpEu-RhF+W...P.Gt.RPDD...........................	0	67	157	220
+6909	PF07081	DUF1349		Protein of unknown function (DUF1349)	Moxon SJ	anon	Pfam-B_14150 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins but contains one sequence (Swiss:P40893) from Saccharomyces cerevisiae. Members of this family are typically around 200 residues in length. The function of this family is unknown.	28.00	28.00	28.80	28.40	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.08	0.71	-4.93	37	701	2009-01-15 18:05:59	2003-08-26 13:54:08	6	18	553	4	274	639	31	174.40	25	72.45	CHANGED	pWhNcPtpaphss.ctlplsTssp.TDFWppTaYGF..ppcsuphlhhpspsc.F.ohpl+lps.sapshaDQuGLhlhlD-c......sWlKsulEa.sDGhspluoVVTp.shSDWuss.h...ssscphahRloRpssshplph.ShDGppaphlRlsh.a.................sspshplGhhuCSPp.psGhpspFs-hplsss..psh	...........................................hh.p.P.t.hphp......p...ptlplps.tsp.TDhWpc.....o..h..Y.u..F.........ptp.s......u.........h..h......h.....hp.h.....t..........s...........s..F..phplplph...sh..p...p..........haD..QuGLhlhh...sp.p...............................pWlKs..ulEa.....s-uhs...p.lu..oV.l.Ts.....s...hSD......Wu.sssh.................sss..p.....p..h..h.h...RlsR....p....t..s..s.......h....tl...h...u.h...-.............u...........p.p.ap..h...R.lsh..ht.........................tsp..shp...lGhhsss.P.......p......ppG......hp...sp..Fpphplp.......h.........................................................................................	0	73	157	225
+6910	PF07082	DUF1350		Protein of unknown function (DUF1350)	Moxon SJ	anon	Pfam-B_14167 (release 10.0)	Family	This family consists of several hypothetical proteins from both cyanobacteria and plants. Members of this family are typically around 250 residues in length. The function of this family is unknown but the species distribution indicates that the family may be involved in photosynthesis.	21.70	21.70	21.80	24.50	20.40	21.60	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.63	0.70	-5.31	3	176	2012-10-03 11:45:05	2003-08-26 13:57:17	6	3	104	0	94	183	162	222.70	31	76.11	CHANGED	EW+EIRGNWVLVPppPlGlIHFLGGAFVATAPpLTYRWLLEcLGcAGYVVIATPFVNTFDHtAIApSVLN+FEhsLERLp+pGulssuhLPlYGLGHSMGCKLHLLIGSLY-VERAGNILlAFNNYPAKQAIPa........lDpFsTul.............ulEFTPSPpETN+LIQEsYsVRRNLLIKFsNDDIDQTAuLRsILps+FuDMVTApsLPGNHLTPLGQDlKWQTGuEFSPLDALGQWlKQSLapDLspLp+slLcWLNP	.................................tts.ahhhP.......p....Ph...ullcFlGGuFlus.s.PploY+hhLEpLu.p.p.G.a.hllAsPa.ss..s.....FDH.thAppl...ht.p....Fc.p.......s...h.p..tL.....p........p.........................h................t........L...P......h......a.......u............lGHShGshlHLL..l..........s.s...........h...h....ss.....p......+...s.......us..lhhuFNN..hssppulPh...........................hp..ph..s........h......................................................................t...EFsPoPpE.....T.pl.lpp...Y...t...hpps..LLl..+FpsDpl.D.po..L..ph.Lp..t.......c......s......s..h.......h..p......hh.Ls.GsHhtP........htt.....................................................................................................................................................................................................................................	0	29	65	86
+6911	PF07083	DUF1351		Protein of unknown function (DUF1351)	Moxon SJ	anon	Pfam-B_14178 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 230 residues in length. The function of this family is unknown.	21.60	21.60	21.60	22.50	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.18	0.70	-4.71	14	177	2009-09-10 23:43:51	2003-08-26 14:05:05	6	2	167	0	23	155	3	211.50	23	68.34	CHANGED	p-lp..lphpPApIp.hshEphcpplsplspcY.pshlVTs-shppcKpphAcLpKltKslsccRhclc+phspPhs-F-thhK.plhp.lcsslspIspslK-h--+p+p.+hcpl+thlschsschtl-tp.hcph.....hpssahssshshKK.lhcplcphlptchpchpphpsscpsIppt.........stp.....slssssYlchLcp.psls-lhsphcsD....h-hp+pp	....................php..lphpsutIp..sh-plcptlsphlscY..psh..h...sT...s..-slp-sKp...sRAcLN....Kltptl-spRKclK+phscPhc-F-pplK.c.hh...t..lc.pshspIspslKpaE-pp+ptRhcplpthlschstpht..lsh.p.hc.h.........hpspahsc.....sh......shKK..hhcc....lss...hh....tt...hpchpphcpspphlpph.............stt.............hshss.sal.phlcp...shs-lht.hcps....h.h...................................................................	0	7	16	21
+6912	PF07084	Spot_14		Thyroid hormone-inducible hepatic protein Spot 14	Moxon SJ	anon	Pfam-B_14186 (release 10.0)	Family	This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesise triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression [1]. Spot 14 protein is thought to be required for induction of hepatic lipogenesis [2].	19.80	19.80	25.40	21.00	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.01	0.71	-4.36	10	191	2009-01-15 18:05:59	2003-08-26 14:17:21	7	4	83	1	106	186	0	134.70	30	90.42	CHANGED	MQls.DohspKpSLhNAMNRFluAVNNMDQTVMVPSLLRDVP....Lsppstc...............phpssss......ts.h.stpsDMYsaYlLLKSIRNDlEWGlL.+p......u..Esst+cc...ssssutsscEs...s-tDLEpQFHYHLpGLHoVLSKLT+KAspLTNRYKcEIGhushup	.........................................p....KpslhssMpRahusVpsM-pTlMlPSLL.RDl.l.tptt.p......................................................t.ttDhYphY.hLKu.I+s-l-aG..............lh....pt.......................t...p.t.t..ppp..................p...s...tt.pt...ttp.-L....E...tpF+hHlpGLaplLscLTppAp.LTp+Ypp.hG......t...............................................	0	22	32	69
+6913	PF07085	DRTGG		DRTGG domain	Bateman A	anon	Bateman A	Domain	This presumed domain is about 120 amino acids in length. It is found associated with CBS domains Pfam:PF00571, as well as the CbiA domain Pfam:PF01656.  The function of this domain is unknown. It is named the DRTGG domain after some of the most conserved residues. This domain may be very distantly related to a pair of CBS domains. There are no significant sequence similarities, but its length and association with CBS domains supports this idea (Bateman A, pers. obs.).	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.00	0.72	-4.43	171	2967	2012-10-03 03:17:47	2003-08-26 14:50:23	7	34	2600	6	655	1966	228	107.60	30	20.44	CHANGED	-lsctLsucllsusptttcp.lpchhluAMshpshlphlct.....sslllssGDR..sDl.luAltss.......huulllT.Guhpsssplhclscptt....lPllssshDTassuphlsph	................................................................-lschlsupllsss.-th...p+c..lpphsl.u..Ahs...l.p...s...h..lc..a...hcs.............GsLlls.uDR....s-.l.hlsAhhss..............huulLlT....G...G...ac....s....s...sclhcLscctt..............lPllpss...hsTapsuthlpp..................................	0	237	457	587
+6914	PF07086	DUF1352		Protein of unknown function (DUF1352)	Moxon SJ	anon	Pfam-B_14369 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 190 residues in length. The function of this family is unknown.	22.20	22.20	23.00	22.70	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.35	0.71	-4.66	10	145	2009-01-15 18:05:59	2003-08-26 14:54:03	7	3	112	0	88	133	0	171.20	36	94.47	CHANGED	MASRuGPRAuGTDGSDFpHRERVAuHYQMS.....sshKSElKKLIhlHhLIWlLlsApluVupL........tLlS+cpVuhPYQWEYPYLLSllPSllGLhuhP+NpISYLVlSMIStGLFuluPLlYGshthFPtupcLa+HGKAhchhhshoAls.............lMYllhVlAlQVHuWQlYYSKKLLDuWhssTpcKK++	...........MASRu.G.sRsuGTDGSDFpaRp+VAs+YQhS..........sphKuclKhhl.....hhHhllahlhhA+.lssshL................hh.lpc.pls.Ph.W.E...Y..s.ahl..SllsohlGlhuh.RNplshLhh.h.l.uhhlhul...hPllau.h...hhsts.phhppscu.ch.hs.shs..............lhYhhhhl...uhQlHsa.plY.auhpLlpuWhststtc.......................................................................	0	29	41	64
+6915	PF07087	DUF1353		Protein of unknown function (DUF1353)	Moxon SJ	anon	Pfam-B_14433 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.	22.50	22.50	22.50	22.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.30	0.72	-4.52	35	353	2009-01-15 18:05:59	2003-08-26 14:55:52	6	3	263	0	55	251	186	91.10	36	62.82	CHANGED	pacLhps..........hhhpssu.....hhhhVPtG..ap.TDhASIP+hhhslh.sPa.ucYhpAAllHDaLhspt........................ths+cpADplFhcuhtshG..Vsth+thhhahAV	..........................................aclhps..........Yh.p.ps....hl.VPtG.....Fh.TDhAS....lPRl......F.W......s.lh..PPh....GcYhpAullHDaLhcps..........................hps++pADhlFh-uMphhG..Vs+aKthlhYhAV.....................................	0	14	33	45
+6916	PF07088	GvpD		GvpD gas vesicle protein	Moxon SJ	anon	Pfam-B_14302 (release 10.0)	Family	This family consists of several archaeal GvpD gas vesicle proteins. GvpD is thought to be involved in the regulation of gas vesicle formation [1,2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	484	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.87	0.70	-12.68	0.70	-6.18	5	21	2012-10-05 12:31:09	2003-08-26 15:10:38	6	1	15	0	11	437	87	367.10	29	79.27	CHANGED	lcRFFsG-sG+TLLINGAPGTGKTLFTIRGLDVLcR-uDVLYVSTRVDQ-TVaEMY......FcsHuSLD..KTulL.............DLhQDPFtLPhDVDVPFEpLsL-SLLEWVDtIsAsuc+LTIAFDSWcLlYEYLAsRHDsPPD..IcTVTNQLVsLARsuGlRLlLVoETAssSsLEYIVDGVVTL..pVK-D-RGRTRRsLRLEKLRGVRIGNRLQP...FTLADGQFpuITPVELlTscTssspuTWEPts.NssA+FSTGIGDLD..+ILSGGaNR...GSVVHLDLGsDLSRDAWSVLsLPAIRNFLupEMGVAVVPP+EGSPGLLHNDL...NsVLo+uVFDTaCHVFETYAGPo+ut........stpaLsshhTso.SDAlsP.......................stlssp-........asoPlEGGpLcYDPYhEhlEplRcQS-GPLLHVISMDTAapAFETRLGDFANYVA.....LHNDusILITKsGTtLRTRADRVADMHFRLEp.SG-AIsLYGENPLTPLLGIGlccSpsIPKIpLTEMV	..............................................................ppFFptcsGpoLLI.pGtPGTGKThF..o..lc.h.L...s...s...l.p..c..c..t.s..s.h.Yl.S.....T.R.V.s.p.-.sl.a.cha...............h...ct.t..ls............ht..ll...........................c.h.p..p....D.....h..t.....h.........h...t....h...s....l.....Ph.............h...s......l....-.s....l...h...p.a.l....c.p...l.s.s....t...s..c.p...s.....hl.s.lDS...W.....h..lh-h.L.u.s...c.a.ssspc.......l...cslp..s...pLs...........h.....h...c.....c.t.s.....s.+..L...l...l....V......h....E....s....s...c......p.......p.....s........L.........-.....Y.ls.DGVVoL...........phc......ps...p..G.R.hh...R.LpL-KLRGlpIpppha....FTL.t..s.G..pFp..s..hss.s.p.h.h.spp....h.hcPhs...ss.pscaSTGhtDhD..pIhsGGhph...GShlhL-hspsls.pha.hls.h.shtNhlp.thtshll......................................................................................................................................................................................................................................................................................................................................................................................................................	0	6	9	10
+6918	PF07090	DUF1355		Protein of unknown function (DUF1355)	Moxon SJ	anon	Pfam-B_14563 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 250 residues in length. The function of this family is unknown. THe structure of this domain was solved by the Midwest Center for Structural Genomics (MCSG). The structure has been classified as part of the Class-I Glutamine amidotransferase superfamily.	24.40	24.40	24.50	25.00	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.27	0.71	-4.90	13	830	2012-10-03 00:28:14	2003-08-26 15:19:49	6	10	622	13	194	554	141	168.00	35	34.26	CHANGED	+VLllG.ESWstphpHhKGFDpFsol+acpGAchLLpslcsushclcaMPAHp.utpsFPhsh...EpLssYDsllLSDIGuNThLL.stsahc.p.sPstLcLl+-YVspGGuLlMlGGYhSFpGIpu+Apa+pTPlt-VLPVs..........sLshDDR.......VEhPpGhtspshu..cHPlspGLus......-W...P.lLGaN...cl	............................................................+VLhlu.tp.H.t.hp.+.s..h.............K.-.tu.ssh.lh.slhp.s.s...c..D..hhPscp...s.hsFPpsh.....-pL..spaDsIllscluusshL...................sstLc.hI.t.cY.V.p.p.G.Gu.LLMlGG..SF......upusappTs.Lu.-VLPVp.............h.s.ss..cp............lE...pP.....tsp..hps.h..u...cHPlspshs........................ca...s.hhth........................................................................	0	79	129	155
+6919	PF07091	FmrO		Ribosomal RNA methyltransferase (FmrO)	Moxon SJ	anon	Pfam-B_14605 (release 10.0)	Family	This family consists of several bacterial ribosomal RNA methyltransferase (aminoglycoside-resistance methyltransferase) proteins [1,2].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.60	0.70	-5.39	14	272	2012-10-10 17:06:42	2003-08-26 15:26:17	6	1	225	6	8	986	235	174.10	50	65.63	CHANGED	uutKYRslsPssVcRlspcth.spptshtpshKtsKp+LHplhGAal..tts.htthL+pltp.....sssssD.puhpsh.t............t....hhuhHuST+ERLPh..LccFYsplFutlss.PsoVhDlACGLNPLAlPWhshssss.sYhu.DIDpshh-hlsshLshlssttpsplp..Dllss.ssssssDlsLlLKslPsLEpQctGuuhcLlctlsu.hlVVSFPT+oLGGRs+GMtpsYstthEuhsstcsap.hpchphusE.Llal	...............................................................................pphsshcp.cccuphh..........................................................KuLQhl...oApCVKQVEVIRA..R....................R....LLcGpAST...o.....GY.F-N........IEH..C.I....DE....E..FG..p...s..o..l...N..D...K...LLLlGS..G....A..Y..PMTLIQV..A.K.E.T..GA..SV....IGIDIDsQA.V.D.LGR..R..I.....VN.V...L...A........P...N...E.......D..I.sIo........DQc.V.u.....p..L..K.D..I.pD.V.T...a........................................................................................................llhppshsh.........................................................	0	6	7	8
+6920	PF07092	DUF1356		Protein of unknown function (DUF1356)	Moxon SJ	anon	Pfam-B_14617 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.	22.00	22.00	22.00	22.00	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.18	8	192	2009-09-13 19:50:27	2003-08-26 15:34:03	7	5	60	0	95	173	0	197.30	43	86.84	CHANGED	pED..............ps-chLsccspptsIuQFPYVEFTGRDSlTCPTCQGTGcIPptQ.NpLVALIPYSDQRL+PpRTKLYVhLSVlLCLLsSGLVlFFLFPRSVhVsssGlKSVpVsFscpsphVhLslTuoLNIoNsNFYsVpVsslouQVQahKsVIGptphoNlohItPLup+QlsaTVpsclusp.oYhYhaCTlsoIKVHNIVlaMQsoVphSYhuHspQsolEoYcYVDCGuNoT	..............................t...................t.t..spttppt.huphPh.chsG.p.sul...TCPTCQGoGcIPp..tpcspLVALIPauDQRL+PpRTKLYV.hhu....VhlCLLhuuLs..l......FFLFPRSl.Vp.s..G..lpss..hVs..as...........tpp....l.hLslTshLNIoNsNaYsltVps...lospV......a......p.sVlGphph.ssh...Is.Ph.s.p..h.asl.s..h...ttt.....o..ha...hCTh.pIpVHplllhhp..solph.oYh.uH.pQ.s.ppapYVDCttNso.........................................................................	0	19	29	50
+6921	PF07093	SGT1		SGT1 protein	Moxon SJ	anon	Pfam-B_14698 (release 10.0)	Family	This family consists of several eukaryotic SGT1 proteins. Human SGT1 or hSGT1 is known to suppress GCR2 and is highly expressed in the muscle and heart. The function of this family is unknown although it has been speculated that SGT1 may be functionally analogous to the Gcr2p protein of Saccharomyces cerevisiae which is known to be a regulatory factor of glycolytic gene expression [1].	27.00	27.00	28.50	27.10	26.80	26.80	hmmbuild  -o /dev/null --hand HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.94	0.70	-6.13	33	327	2009-01-15 18:05:59	2003-08-26 15:46:34	6	13	251	0	233	314	3	469.20	23	84.08	CHANGED	sVcYpla............t.tsspsphpplpphhtclhscls.hh.....ps.YIWQ.+-sFpLphpptp....................sssaltGpTpa.GDsl-D.EWaIVaLLhclo+pa..sslhs+VhD.sDGEFLLIEAAchLPcWLsP-supNR.VaIppGcLpIIs............t.spt.spslolppAlphlp.spsp.thhtSsplpsslppR.lcsY..Pcp.lppsl...HcAplhlPtplAtlL+p..cPpLlusAVpAFYhR..DPl.sl+.....sspshphF.....................Pcsh.VpsoVpFT+s.L..YAQLhpQpFs.Psph........................hthPssscs..tactt-.......LGhKL............................usGFEhLhspsctptpssp...........ss.thpshLcsLpcsGhhp.s.l.sspchpphhp.s............................................................................t...t...spDDDsWLs.ls.--L-p.Lpp....+ttpppthp.spppp.....s.....................................sLpclspphpsFlsc.tusa-Gs......-h.................................................................................................................................................................................................spsspcpslsh........D....t-pFhc.hhcchLshsss-.ss..s..............................sshtc.csp-s-sps--.............t.p............stpplpphhppM-pELttoshhp.....................stttpt.pstsp............................tptsstsp.t.....pslDlD	..........................................................................t.lpp.h.phht....h.............tYlWp.ppshp..lphh.tp........................................h...hlh..G.hhpa.GD.slcD.EWhlValLhplocpa....splhh.+...l...D.sDGE..FLLIEA..Aph.LP..pWl.p..P.-.s..........s.pNR.V.alppGpLtlls................................................sps..sl.pAlph..lt..spst..thht.........sttlptth.tR.lpt..a.....Ppp...hpp.sh.........HpshshlP.tt.l.u.tlLcp..pPphlu.AlpuF.h.R..Dsh..sh+......................tspt.h..hF........................................................s.p.ph.lhsslphT+s.h..YApLh..pp..pa....ss.....................................hs..tp......thtthp.................lGhKl...........................................................spGhEhlhp...p.t.pptt...........................................s..ht.hhppL.pps..t....l.sst.ph.phhp....................................................................................................pDs-pWhp.hs.pph.-p.Lpt.............t.tt.t..t.tt..t....................................................thtphspphptFlpp....us...hcGs.......c..h...........................................................................................................................................................................................................p.p.pt.hph...................................-.......ppF.p..hhcph.hs.......tt....tt...........................................................................t..t....p.tt............................................................................................................p.tthpph.tth-tELtttth.p...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	80	131	195
+6922	PF07094	DUF1357		Protein of unknown function (DUF1357)	Moxon SJ	anon	Pfam-B_14833 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 225 residues in length. Members of this family appear to be specific Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	21.90	21.90	22.20	40.60	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.43	0.70	-4.90	3	130	2010-01-12 09:55:36	2003-08-26 16:05:37	6	3	27	0	10	107	0	192.30	66	94.63	CHANGED	MpsKE-pEDSpclsSpsspV..psDsllISApEFEEY++aK-psNscSKtoH+DLSINERlo+ELAEVpEREulpcpLLhEApRINEIDTLAscaLSNHFNKEsLLAKGYSLKEIlpAQuRELIRKYVssEQIKAIAKVssl-HIDGchLEQLlcLAKVNIKQRKNAEsNa+olsplRsNh.VKhcE+sSLpNSNFhPIN+TELscAM.Npacph+IQFYpNpK+	................hhEcEEKEDLpsQsK--pQl..KuDTKVISspEFEEYh+hKEQu.N......s.K.....s.K.EosRDLSINERITKELAEVEERERlEKQLLLEAERINEIDTLAKAHLSsHFNKEsLLAKGYTLKD.IMQAQRRELVRKFVPIEQIKAIAKsSDISHIDGEILEQLVSLAKVNIKLRKNAsSsSSSVDuIKGNIhhKSEERsSLLDSNFVPINFTEFVQAISNTYKQRRhQFYENLKR...........	0	5	5	5
+6923	PF07095	IgaA		Intracellular growth attenuator protein IgaA	Moxon SJ	anon	Pfam-B_14923 (release 10.0)	Family	This family consists of several bacterial intracellular growth attenuator  (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria [1]. 	25.00	25.00	26.10	31.00	23.70	21.20	hmmbuild  -o /dev/null HMM SEED	706	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.52	0.70	-13.02	0.70	-6.78	10	600	2009-09-10 22:06:59	2003-08-26 16:21:33	6	1	546	0	41	315	4	641.80	75	99.32	CHANGED	MSTIVllLAhlLAClllsGhhlth+tR.R+.tlshh.uFucsTsRKLTu-ERuAIEsYL.pp.sp.......hhsoPssouuoussspLsLsspSDsVYslT+AITRYGlooD-PNKWRYYLDSlEVHLPPFWEQYIs--NsVELI+TsSlPLVISLNGHoLp-ahp-ts.u.sLppsuss.....pASIRpEESEplELLNIRKET.EE+ALs+PsGl+EAsLIsAuFLLaFFuLloPsVhlPWLsusAlLLluhGLWsLFpPPucssLRElHCLRGTPKRWGLFGEssQGQIsNISLGIIDLIYPsHWQPYIApDLGpKTDIDIYLNRQVVRQGRaLSLHDEVKNFPLQ+WhRNhllsAGSLLVLlLLlhaVPLslPlKLoloWL+GAQTlElToVspLEcAtLRlGDTL+spGTGMCYl.sPsp..hSsppsosFhPFDCSuIYWNsAsPLPlPES-Tl-KAoALlpoVN+QLHPp.-s-s+VNPsLuSAIQKSGMlLLDDFuDIVLKTQDLCss-.sDClRLKNALVNLGNsKDWsoLVKRAcuGKL-GlNVLLRPVSAEoLEsLVsooTusFlhRETs+AApuLNSPPPGGFLItSDEGKQLVspPhPsl......sLaDYsuhEQWpELQRLusMLLHTPFpAEGIlTslsTDANGTpHIsLHS.PDpsoLWRYlGTTLLLLshlsshlaNuVhslRRhp+sRpRhp-IQ+YY-sCFNspLhPss....c	...................MSTIlIFLAALLACSLLAGWhh+V+SR.R+.pLPWssAFsDAQTRKLTPEERSAVENYL..-.sLoQ........lhQVPG...P..TG..A..SA.APISLs.LNAESNNVhhLTHAITRYGIoTDD.PNKWRYYLDSVEVHLPPFWEQYINDENsVELIhTDoLPLVISLNGHT.L.Q..EYM.QEoR..GYALQs.ssST.........................QASIRGEE.SEQIELLNIRKETHEEYALSRPpGLR..EALLIVASFLhFFFCLIT.PDV..FVPWL.sGGAlLLLuAGLWGLFA.PPu..K..............SuLREIHCLRGTPRRWGL.FGENsQEQIN.NISLG.IIDLlYPAHWQPYIuQDLGQQTDIDIYLD.R.HVVRQGRaLSLHDEVKNFPLQHWLRSTlIA.uGSLLVLFM..LLFWIPLDMPLKFTLSWMKGAQTIEATSVKQLscAGVRVGDTL+lSGTGMCNI+ouuT..W.S..u.po..NSPFhPFDCSQIIWN....DApuLPLPES-LVNKAsALopAVNRQLHPK.PED...-....SRV......S..ASLR......SAIQKSG.MVLLDDFGDIVLKTADLC.......SAc.....DDCVRLKNA.....LV.N.L....G.NSKD....WsALVK..RANAGKLD..GV..NVLLRPVSAESL-NLVsTSTAPFIo+ETARAAQSLNSPAPGGFLIsSDEGS-hVDQPWPSs......sLYD.YPsQEQWsAFQ+LAQMLMc...TPFsAEGIVTpIaTDANGTQHIuLHsIPD+SGLWRYLuTTLLLLsMlsSAlYNGlQAaRRYQRHRTRMhcIQtYYESCLNPpLhss.p...................	0	1	9	24
+6924	PF07096	DUF1358		Protein of unknown function (DUF1358)	Moxon SJ	anon	Pfam-B_14731 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 125 residues in length. The function of this family is unknown.	20.90	20.90	20.90	21.50	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.51	0.71	-4.44	5	99	2009-01-15 18:05:59	2003-08-26 16:24:23	6	4	80	0	65	112	0	110.40	41	68.73	CHANGED	MtothspsGpossu..psssu-cERKFRl+GGAFLGsVAusuAlAGFS+TLuhAKKuDPcaF.sKGlpuolAL.EoGoSLALRALGWGTLYAaLGTGsICFGlWKLoGA+sMpEFRpKMGoIFPRI	.............................................tststcc+hFhlpuuh..FLGsVuusuhLuGFspTLuhAKKpsPcaF.s+Gsh..ustuL.EoGuoLALRALGWGoLYAhsGsGllsaulWKhhGl+shp-FR.KMtshhPtl...............	0	23	29	44
+6925	PF07097	DUF1359		Protein of unknown function (DUF1359)	Moxon SJ	anon	Pfam-B_14784 (release 10.0)	Family	This family consists of several hypothetical bacterial and phage proteins of around 100 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this species. The function of this family is unknown.	25.00	25.00	133.60	133.50	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.30	0.72	-3.97	2	9	2009-09-11 08:58:17	2003-08-26 16:27:01	6	1	6	0	3	4	0	98.10	68	94.24	CHANGED	M.pEhpl..pcpItphppKhsRLpplIHtl+pQ....cll.DchpsscIppssKFthpLs...uhhcsshpIsVGTLIsLLcpNIEsNTslhsELstcLGI-lc	MsQEITlDFSEQIAKsQTKIsRLKchIHcVRcQ....KIVLDDlKNNHhs+DTKhELNLG...GVLKCSVKINVGTLIPLLEQNIEDNTsLIpELAKELGIDIK	0	3	3	3
+6926	PF07098	DUF1360		Protein of unknown function (DUF1360)	Moxon SJ	anon	Pfam-B_14863 (release 10.0)	Family	This family consists of several bacterial proteins of around 115 residues in length. Members of this family are found in Bacillus species and Streptomyces coelicolor, the function of the family is unknown.	20.90	20.90	21.10	21.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.37	0.72	-4.31	21	265	2009-01-15 18:05:59	2003-08-26 16:44:47	6	1	226	0	60	183	34	103.80	37	75.40	CHANGED	llslAoaRLTRLIVaDpITsalRpPFhcptcph..p.GpsEshhss+u..stlRphlGELLSCYWCTGlWsAshlhhualhhPchsp.llhlLuIAGuAul.lEshlu+	...........................lhsLAsaRLTRLIVaD+I.TuhLRpPFhcc.......hc.......hs.......-........s...Gsspshpt.s+u....pulR.phlGEL..LoCaWCsGlWlushlh..ss..h...sal..P....phupsl..lhlLAlAGuuul.lEshhu.h......................	0	16	41	49
+6927	PF07099	DUF1361		Protein of unknown function (DUF1361)	Moxon SJ	anon	Pfam-B_14870 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although some members are annotated as being putative integral membrane proteins.	25.00	25.00	26.30	26.30	21.30	23.70	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.28	0.71	-4.43	31	569	2009-01-15 18:05:59	2003-08-26 16:47:59	6	3	546	0	84	337	14	166.00	36	79.45	CHANGED	lWNlFLAhlPhtluhhlphh+sp........hlhhlhsllWLlFhPNA.YllTDllHLp................hhtshsht.ahthhhlhsushhulhhGhhShhhlhphhpph........h.thhlhhslhhLsuhGIYlGRFhRhNSW-llspPpsllpplls.l.....ptcthhFllhhshl.lhlh	.................................hhNlFLAYIPhELu...lLL....phhK.p....................h.lahlh.uhlallhhPNs.YhlTDLlHLp............htashhh.shshspWhhFsh..Llhulhhulhlshhsh..hpl....hp..h...hppp...........hh...phlllssLhaLsuhGIYIGRF.........hRLpShalhs.pPhpllpclhpsl.....shc.ph...hFlhhhshhQhhl.h..........................	0	25	59	75
+6928	PF07100	ASRT	DUF1362;	Anabaena sensory rhodopsin transducer	Moxon SJ	anon	Pfam-B_14972 (release 10.0)	Family	The family of bacterial Anabaena sensory rhodopsin transducers are likely to bind sugars or related metabolites. The entire protein is comprised of a single globular domain with an eight-stranded beta-sandwich fold. There are a few characteristics which define this beta-sandwich fold as being distinct from other so-named folds, and these are: 1) a well conserved tryptophan, usually following a polar residue, present at the start of the first strand; this tryptophan appears to be central to a hydrophobic interaction required to hold the two beta-sheets of the sandwich together, and 2) a nearly absolutely conserved asparagine located at the end of the second beta-strand, that hydrogen bonds with the backbone carbonyls of the residues 2 and 4 positions downstream from it, thereby stabilising the characteristic tight turn between strands 2 and 3 of the structure.	25.00	25.00	28.30	30.40	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.55	0.71	-4.37	25	78	2009-09-25 12:58:53	2003-08-26 16:50:45	6	2	67	25	33	77	31	117.60	44	90.17	CHANGED	slGc+pWsIs-GYIPspSsGsp.thsSHEslClLNsuDc-A+lplTlYFsDR-PlGPaclsVsuRRThHlRhN..-L.-PpsIPpsssYAsllES-VPVVVQaoRLDoR.QuphALhoTlAYss	..t.lGcppWsIs-GYIPspSsGs.............hsSHEslClLNsuDpsAclclolaFpDR-PlssaclsVsARRTpHlRhs..-LtcsEslPpsssYAhllcSDlPlVVQaoRLDop.QuphALhoThAYs.s.....	0	12	23	28
+6929	PF07101	DUF1363		Protein of unknown function (DUF1363)	Moxon SJ	anon	Pfam-B_14992 (release 10.0)	Family	This family consists of several Trypanosoma brucei putative variant specific antigen proteins of around 80 residues in length.	19.50	19.50	23.20	85.50	17.70	17.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.05	2	14	2009-01-15 18:05:59	2003-08-27 09:26:29	6	1	4	0	0	11	1	102.00	73	95.07	CHANGED	MSRHGNIDIGCGAGNTMDATFRSCTPHESFYYLSINHDLKAREAQNNNTNSDTICFSTHLHKRSNRRLDRRCEYIFGICSIKGNSAARRKKFLpTPLCQRYlNNCLKYMHSICHYQTRPGRTSS	..................MS.cGNIDIGCGAGNTMDAsFRSCT.HESaYYLSINHDLKAREAQNNNTNSDThpFSTpLHKRSNR+LDRRCEYIFGhCSIKGNSAARRKKFLKTPLCQRYLNN................................	2	0	0	0
+6930	PF07102	DUF1364		Protein of unknown function (DUF1364)	Moxon SJ	anon	Pfam-B_14821 (release 10.0)	Family	This family consists of several bacterial and phage proteins of around 95 residues in length. The function of this family is unknown. 	29.50	29.50	29.50	29.50	29.10	29.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.38	0.72	-4.11	13	531	2009-01-15 18:05:59	2003-08-27 09:33:10	7	4	387	1	29	247	9	91.50	59	93.90	CHANGED	pscLRcAARGcpCplRIPGlCNtNPETTVLAH...hRhsuhpGsGhKscDhhusaACSuCHDtIDuRs+t...hspEphchhthcGlhRTtthLhccGhl	........................MusLRKtARGRECQVRIsGl.....CNG...NP..EToVL.AH.......hRhAG.hCGT..G..hKPsDLluAhACSuCHDEIDRRT+h.......lDs..c-s+hhtlEGlhRTQsIhlKEGhl............................	0	3	9	19
+6931	PF07103	DUF1365		Protein of unknown function (DUF1365)	Moxon SJ	anon	Pfam-B_14846 (release 10.0)	Family	This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.	25.00	25.00	26.80	26.50	24.50	24.10	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.76	0.70	-5.33	104	812	2009-01-15 18:05:59	2003-08-27 09:37:11	6	11	766	0	319	782	1520	234.30	30	80.99	CHANGED	uslahGpVhHpRhpPhpHpFpYplhhhhlDLD..-ls.................th...phst.hauhs+h.shhuF+cpDa.........................ushpts......ltshlpph...tGhp.s..GclhLLspsRhhGasFNPlShYaCacpssp.....L.psllAEVsNT.as-RHsYllsh...............tstphpscKsFHVSPFhshchpYca+hs.s......sc.cltl.....plp.p......................pt.................hhsAolshpRpP......LosssLhcshlphPhhol+llsuIaWQAL+L.alKtlPhhs.+Pss.pp	......................................................................tlh.GplhHpRh....t..P...h..p..HpFpY..phhhhhlDLD........cls...............................................................pl......th.h..hhu.....p....t..h...sh...hp..FcppD.ah..................................................................s.sh.pts.....ltsp.lpph...........pGhp.s...GclhhLspsRhh.Ga.h.FNPlohaasa........cp.ssp.....................L.phllAEVsNT.asERHsYllss.................................tthphphsK.sFHVSPF.sh.p.t.pYp...a+hp.s................sc..pltl.........plphp....................................pt..................tthhsAols.....hp.tps........lo.s.t....s...l.....hp.....hhhphPhhs.h+lhh.....tIaWpA..l+L.ah.K..t.s.Phhs+Pt...p...............................................................	0	91	197	265
+6932	PF07104	DUF1366		Protein of unknown function (DUF1366)	Moxon SJ, Sammut SJ	anon	Pfam-B_14849 (release 10.0)	Family	This family consists of several hypothetical Streptococcus thermophilus bacteriophage proteins of around 130 residues in length. One of the sequences in this family, from phage Sfi11 (Swiss:O80186) is known as Gp149. The function of this family is unknown. 	21.60	21.60	21.60	22.00	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.45	0.71	-4.47	7	78	2009-01-15 18:05:59	2003-08-27 09:44:18	6	1	46	0	9	64	0	113.10	35	67.89	CHANGED	M.hEatup..ph.sstustusKVlLcspD...Gu.lPlhLPsEhhDhopsElLpps.clIYQc.aPp+AEsEKFs-Ls.......t..th.ptp.sKhEphhphuosTL.slIsphhtccshsD-sl	..............h...plsuKYPphDuoGulsuT+VIlss-D...GuhIs.h..l.pDhhspssoEllctsLEpahcppas-hAhuEthpKlD..............-..cKh.pppssK...stcs...spsA......................shh.............................	0	0	6	8
+6933	PF07105	DUF1367		Protein of unknown function (DUF1367)	Moxon SJ	anon	Pfam-B_14892 (release 10.0)	Family	This family consists of several highly conserved, hypothetical phage proteins of around 200 residues in length. The function of this family is unknown. Some proteins are annotated as IrsA (intracellular response to stress).	25.00	25.00	27.30	25.20	18.40	24.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.24	0.71	-4.90	9	383	2009-01-15 18:05:59	2003-08-27 09:48:02	6	3	265	0	27	249	3	156.50	44	98.30	CHANGED	MA.phphIKpusGhLlPATP-sp-hLp.+hKhGsVlhu-F....KpVRNPtFHRKFFALLsLGFEYWEPsGGslospEpcLlpGaspaLstasGpc..ssLt-hAspYLtplutcR.ssslulpKSF-AFRcWVTVEAGaYclhphPDGolt+cP+SISFAuMD-hEFppLY+usLsVLWpaIL..sRpFsopp-sEsAAsQLhsFs	...................MA.c.lphlKp.usGlLlPATscst-h.......Lp.plKlGt.hlh.A-.F....+ps..RN...AFH++FF.t.LLpLGF-YWpPsGGslostEpcLlpGaspaLst...sGpc....ssL.....psA-pYLpplAppR..st..s..h..ulhKSF-AaRtWVTlpAGaYs.th.hP.DGoht++s+SIuFusMD.-sEFpplYKusLsVLWpaIL...RpFpo.ppsENsAuQLhpFA..............................	0	0	7	17
+6934	PF07106	TBPIP		Tat binding protein 1(TBP-1)-interacting protein (TBPIP)	Moxon SJ	anon	Pfam-B_14830 (release 10.0)	Family	This family consists of several eukaryotic TBP-1 interacting protein (TBPIP) sequences. TBP-1 has been demonstrated to interact with the human immunodeficiency virus type 1 (HIV-1) viral protein Tat, then modulate the essential replication process of HIV. In addition, TBP-1 has been shown to be a component of the 26S proteasome, a basic multiprotein complex that degrades ubiquitinated proteins in an ATP-dependent fashion. Human TBPIP interacts with human TBP-1 then modulates the inhibitory action of human TBP-1 on HIV-Tat-mediated transactivation [1].	30.00	30.00	30.20	30.00	29.90	29.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.19	0.71	-4.71	12	266	2012-10-04 14:01:12	2003-08-27 11:17:55	8	8	222	0	184	281	2	151.20	26	63.87	CHANGED	-ApshlhcYlpcpNRPaSsp-lhsNLpp..tluKssVpKsL-pLspps+IhpK.YGKt.KIYhssQpphc.ssst-lpclchc.lppLppclptlppphpplppcl+pLppsLsst-lhcplppl+cclpphcc+Lcslcp.shp...lo.--hpplhpppphhpptapKRK+hhp	...............................thlhpahpppNRPasspslhsNLpp...tlsK.stl...KsL-pLspp......sclhtK...h.....GKp..+lY..hspQs........ph.p............ss........st-.lpthctp....lt....pLppplpplppphpphc.scLppLpuphost-.hppplppLcp.-....hpphpp+Lpplc......s...sssh........ls.s..--tp......pl....cphpphpppapcRK+hh............................................	0	74	108	153
+6935	PF07107	WI12		Wound-induced protein WI12	Moxon SJ	anon	Pfam-B_15477 (release 10.0)	Domain	This family consists of several plant wound-induced protein sequences related to WI12 from Mesembryanthemum crystallinum (Swiss:Q9XES3). Wounding, methyl jasmonate, and pathogen infection is known to induce local WI12 expression. WI12 expression is also thought to be developmentally controlled in the placenta and developing seeds. WI12 preferentially accumulates in the cell wall and it has been suggested that it plays a role in the reinforcement of cell wall composition after wounding and during plant development [1]. This family seems partly related to the NTF2-like superfamily.	21.50	21.50	21.50	22.30	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.66	0.72	-4.17	7	77	2012-10-03 02:27:23	2003-08-27 11:26:04	6	4	22	0	43	83	0	103.80	44	66.72	CHANGED	MRLLTG.us.usuSFpFpPpSVsuF...GssVlAEG.sDsspplhWVHAWTVs...sG..lITplREYhNTsLTVTRlu.sssuptst...................pspslWpSphssRAtKslPuLlLAl	....................................M+lLTG...ts.........p.....p..s.......u..........FpF.Ppulsuh.......Gs.sVlAEG......t.p..stp.........h...YWVHAWTVs...sG..lITQlREYFNTsLTVTcls..s.t.......................................ttstslWpSph.....s..-.ht+SlPGLVLAI........................	1	5	30	38
+6936	PF07108	PipA		PipA protein	Moxon SJ	anon	Pfam-B_15507 (release 10.0)	Family	This family consists of several Salmonella PipA (pathogenicity island-encoded protein A) and related phage sequences. PipA is thought to contribute to enteric but not to systemic salmonellosis [1]. The family carries a highly conserved HEXXH sequence motif along with several highly conserved glutamic acid residues which might be indicative of the family being a metallo-peptidase.	25.00	25.00	28.80	109.90	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.27	0.71	-4.94	4	164	2009-01-15 18:05:59	2003-08-27 11:31:57	6	1	116	0	4	64	0	174.20	86	93.04	CHANGED	sssFPDlPEHussPS.lRLuaDplATNS-h+LcP.EplsEYhISGsGGIDPDhEIDDDhYsECapcLSpILpsAYTQStTFRRLMNYAYDpELaDlEpRWLLGAGEsFuTTVTsE-LpsSpGRKVIsLNLD-ssD.sshPEpYESs-GP.p.FDTpRSFhHEIVHALTpLpDcE-NHPRGPVVEYTNIILKEMGppSPPRItY	........................................phVEYLISGAGGIDPDTEIDDDTYDECYDELSSVLQNAYTQSETFRRLMNYAYEKELHDVEQRWLLGAGEAFETTVAQEHFKLSEGRKVICLNLDDSD..DSYTEHYESNEG..QLFDTKRSFIHEVVHALTHLQDKEENHPRGPVVEYTNIILKEMGHPSPPRMsY..	0	0	0	3
+6937	PF07109	Mg-por_mtran_C		Magnesium-protoporphyrin IX methyltransferase C-terminus	Vella Briffa B	anon	Pfam-B_12015 (release 10.0)	Family	This family represents the C-terminus (approximately 100 residues) of bacterial and eukaryotic Magnesium-protoporphyrin IX methyltransferase (EC:2.1.1.11). This converts magnesium-protoporphyrin IX to magnesium-protoporphyrin IX methylester using S-adenosyl-L-methionine as a cofactor [1].	19.70	19.70	23.30	22.40	17.40	15.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.11	0.72	-3.94	15	218	2012-10-10 17:06:42	2003-08-27 11:38:22	6	12	204	0	98	221	233	97.50	38	40.22	CHANGED	shDsLIHYsspDssthLu+LuShspppllhoFAP+TshLshh+pIGcLFPtusRosthh.Hu.pslp+tlss....tGapls+pthlostFYhSphLEhs.	..ChDVLIHYPppcssphls+LuuhscppllhoFAP+TshLslh+tlGclFPtss+s..Tphh.hpEpsltctl..tp.....sG..a..pltRpphssssFYhSpllEhh..................	0	26	59	80
+6938	PF07110	EthD		EthD domain	Moxon SJ, Bateman A	anon	Pfam-B_15539 (release 10.0)	Domain	This family consists of several bacterial sequences which are related to the EthD protein of Rhodococcus ruber (Swiss:Q93EX2). In Rhodococcus ruber, EthD is thought to be involved in the degradation of ethyl tert-butyl ether (ETBE). EthD synthesis is induced by ETBE but it's exact function is unknown, it is however thought to be essential to the ETBE degradation system.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.11	0.72	-3.05	57	827	2012-10-02 00:20:33	2003-08-27 11:42:09	6	16	516	4	432	846	223	86.60	19	56.80	CHANGED	suho.ccFpcaapphHuslstplhs.......h.ta....................h..ttthhhhtsstsshsaDuhsphha...p..shcshhshhpsPthtt....ltsDc.tpFsDts	.............................................hs.ttat.caapppHs.s.l.stph.u.................................................h.hhttths.t.s..hsss...sssa....cuhschhF......c...shcsh.t...s....u...hs...ss...phpt...........hhsD...pFh...t.........................	0	94	256	355
+6939	PF07111	HCR		Alpha helical coiled-coil rod protein (HCR)	Moxon SJ	anon	Pfam-B_15548 (release 10.0)	Family	This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation [1].	20.70	20.70	20.80	20.80	19.40	20.60	hmmbuild  -o /dev/null HMM SEED	739	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.47	0.70	-13.35	0.70	-6.53	3	174	2009-01-15 18:05:59	2003-08-27 11:50:30	7	5	41	0	36	159	0	342.80	49	90.71	CHANGED	MAPTWASDlPLVQuPupQDVLERRLDsQRspVTMWGpDsu.uDuQ-PGRRGRSh-LEtSQALSQQAELISRQLQELRRLEEEVR.LRETSLQQKMRLEAQAhELEALAhAEKAGRAEAEGLRAALAGAEhVRKNLEEGuQ+ELEElQRLHQEQLSSLTQAHpEALSSLsSKAEGLEKSLsSLETRRAGEAKpLAtAQ+EADhLRcQLSKTQEELEAQVTLVEsLRKYVGEQVluEs+SQsWELERpELL-TlKHLQEDRAuLQATVELLQVRVQSLTHILALQEEELTRKlQPlDsLEPEFsRKCRSLLsRWREKVFALMVQLKAQELpHuDSTsQL+tQVAELQEcVTSQSQEQAILQRSLQDKsAEVEVERMuoKuLQhELSRAQEARRRhQQQlASAEEQL+LVVsAVsSSQttLpoTMA+VEpAlAQLPSLSNRLSYAVRKVHTI+GLlARKVALAQLRQESSPP...APu.ssDLSlELcQLREERNRLDAELQLSARLIQQEVGRAREQGEsERQRLuEVAQQLERELQcoQESLASlGtQLEAARpGQQESTEEAASLRQELTQQQElYGQALQEKVAEVETRLREQLSDTERRLNEARREHAKAVVSLRQIQR+AAQEKERNQELRRLQEEARKEEGQRLoRRLQELERDKNLML..............QRLLsVLPSulsKK....sSPRPlEsSuStSlPAAsPsRESlKGSLTVLLDsLQGLSEAIS+-EslC.tDN.cs+oSsNPPsoP	.......................................................................................oht...htsSpu...LSQQAElIsRQLQElp.LEtEl...LREsS.lp.Qph+LEsQA.....EL-..tLt...t-p...sup....sE..sEtL+ttlutut..+.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	9	14	20
+6940	PF07112	DUF1368		Protein of unknown function (DUF1368)	Moxon SJ	anon	Pfam-B_14994 (release 10.0)	Family	This family consists of several proteins with seem to be specific to red algae plasmids. Members of this family are typically around 415 residues in length. The function of this family is unknown.	25.00	25.00	33.20	33.00	18.90	18.60	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.40	0.70	-5.87	5	9	2009-01-15 18:05:59	2003-08-27 11:53:47	6	1	4	0	0	10	0	326.00	37	95.41	CHANGED	EVcR..IoclllcS.chSKQYFLYKScslV.SsSsSEDDWpYCLLILKFlsPpsslKsIopILEaFL+cDRYRDKFsccauYLsTTIpKVIlpSSppNLlGssYspso...+-lIQ.sulDShaspss.I+sS.CosssVLKIsNFhShFaLcpsKYSsplhDaclshososNsolKISMhGGLLNYFDLMlFLuILYsY....KlsopLssssI.......lcINFSs.l-hMLpsNGo.sR+KYlNSLcKLSKVHL-s..p.h.shlsshpsspcphhsFSGsLLoFEpLSssp.Tpssl.hLSpPll..+hhcS.ssYSlVNWsSFlsLssoplRLlYFYFCLNVKsSpY.FTpFolcpLlccLYsusshuSohRhh+SclRKhLhhlh-sppshlDF-FpLVhs.spSpplISuIKVRRs+lhl.R	.................clhp..I.p.l.pS.p..+pYhlYh.pshh.p.SsSEDDWpaClLlLpalpP.sshchhsplLchFL+pDRaRsKhppp.sYLppTItKsI..u.p.pllGs.h..p....tp.lQ..ulsp.hsp.s.lp.S.sphpsVLKl.NhhShhaLppsphSs.h.chthshs.spssslKlS..hGlLNaFDLhlFluILYta........K..s.h..ssl.......lsINhSs...hshhhpssGp..RtKalNSL.KLS+Vplcs.......h.shh.tsptphhphoupLLsFptlphpp.T.hpl.hLSpPll..+hhp.hsNYSlVNWtSFs.LsssplRLlYFYFCLpVKsSpY.FTpF.lcpllpcLYhusshpoohR.hp.phRp.L..h.p....h.-hphpl.hp..pp..hIp.IKVRR.phh..h..	1	0	0	0
+6942	PF07114	DUF1370		Protein of unknown function (DUF1370)	Moxon SJ	anon	Pfam-B_15274 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 200 residues in length. Members of this family seem to be specific to mammals and their function is unknown.	25.00	25.00	25.50	25.30	24.00	23.60	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.14	0.71	-5.08	6	118	2009-01-15 18:05:59	2003-08-27 12:38:11	6	1	72	0	70	120	0	175.20	33	88.12	CHANGED	su+h+cshIIEhIs+KFcpLPEs-RsLhpaGolYlGhNAuhuGllANSLFRRlL+VoputlsouLPMAsLPFLTTsloYpshVosPL.oGDLsCETCslhRuuLlGlVsGGlYPlhLAlPVNGGLAARYposPLPpKGNIlpaWhslSpPVhKKMuFPLlLQshFGsalGS+HYplh.KsLphs.P-	..........................................hh.hlt+php.L.ct.-..pph..aGsshlGssAuhsGlhuNslFR+tLpV.p.p.u.tlpohLPh.uslPFLoTs...lsY+hhVsp.P.Lho...usl.s.CtsChhhRuuLlGllhGslYPshLAhshNutLAs...+..Ypos......LP....pK...G.....p....ll....haWhplspPlh+tMhhsllhQshFuhalu.....ppatlh.chhph......................................................	0	10	14	35
+6943	PF07115	DUF1371		Protein of unknown function (DUF1371)	Moxon SJ	anon	Pfam-B_15275 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 110 residues in length. The function of this family is unknown but members seem to be specific to Borrelia burgdorferi (Lyme disease spirochete).	24.90	24.90	25.10	25.00	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.51	0.72	-3.90	3	117	2009-01-15 18:05:59	2003-08-27 12:40:45	6	1	31	0	10	64	2	106.60	68	99.47	CHANGED	MDLRIGNNFELVFNNDFSLVDGIEEQKQRLFIFLKTLRGSLSYAPNWGLDYhLLLKLLKINNL-AVKNYFaEISKELNLDLINlSsoIQD+KlHISFFFsG.DVLNMEFcL	...........MDLRlGNNFELV.FNNDLSL.VDGI-EQKQRhhIFLKTLRGSLSYAPpWGLDYhLLLKLLKINNLcAVKNYFaE.ISKEL.N.LDLINISsoIQD...pKspISFFFoG.DlLNMEFsL.............	0	6	6	6
+6944	PF07116	DUF1372		Protein of unknown function (DUF1372)	Moxon SJ	anon	Pfam-B_15278 (release 10.0)	Family	This family consists of several Streptococcus bacteriophage sequences and related proteins from Streptococcus species. Members of this family are typically around 100 residues in length and their function is unknown.	25.00	25.00	36.00	35.80	18.50	17.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.53	0.72	-4.07	7	50	2009-01-15 18:05:59	2003-08-27 12:44:28	6	1	46	0	3	42	0	88.30	43	95.42	CHANGED	Mp........c....s.htlAshlllluhlhshshlhhhhs...s.+.spsllIapVDNuss.MaGKlTsKphltthYTlsstAYGKFLVTKEQYcsIpVGDDIPsYLKG	..........................................hh...................hhshhllluhshshhthhhhht.......c..phcsllIYKsDNsGuElaGKVs-KphlGcLYTlThpsYGhFlVTKEQY-plcVGD-l........	0	0	0	0
+6945	PF07117	DUF1373		Protein of unknown function (DUF1373)	Moxon SJ	anon	Pfam-B_15084 (release 10.0)	Family	This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.	25.00	25.00	25.30	28.00	22.50	24.00	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.64	0.70	-4.60	3	35	2009-01-15 18:05:59	2003-08-27 12:58:46	6	1	1	0	19	10	0	190.70	68	97.25	CHANGED	M.RVLWIsCLLIGSIoCLPQGGss..ssu....hPPYoGQ..ScPSYE+PSGQ.SGYSosPGYYSuGTpTuGGS..GSPPMWYSASYPEQEPAKPTYQRPAQSSGYGSYGuVDSSYSGSGSQQSGSQGAQSGAPGSQHQVEQESWSSSSDDEDEPEFTPVSEEDQVYASKTRSRYNQKRLLFSQFRYTPTEPRVPQEPVFPYPSKSHQGKGSAKGSR	......................RhLWlSCLLIGoIoChP.QtGhs...s...........hh....YoGQ...tPSYE+PStQuS...G...YSS..GhYSuuT...NTAGuS..uosPMWYSASYPEQEPAKPTYQRPA.QSSGYGS.ss...stt.SYSGSGSQQSGSQGuQSGsPGSQHQVEQESWSSSS..D..DEEEPEFTPVSEEDQVYA.KSRSRYNQKRLLFSQFRYTPTEP.RVPQEPVFPYPSK.SHQGKGSAKGSR.....	0	0	0	19
+6946	PF07118	DUF1374		Protein of unknown function (DUF1374)	Moxon SJ	anon	Pfam-B_15191 (release 10.0)	Family	This family consists of several hypothetical Sulfolobus virus proteins of around 100 residues in length. The function of this family is unknown.	20.70	20.70	21.40	21.30	20.00	19.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.94	0.72	-3.88	15	27	2009-09-11 20:35:31	2003-08-27 13:01:18	6	1	6	7	0	32	0	87.10	29	91.45	CHANGED	cFc-LK.sllchFFc-pplpElsLcFpcpl.lTEpEacELIpsschhpphpsp....sIhsDhYpYhEspNphhKL.IcYa+cs-.KIhIhEIchWR-	.....hcplc.pllphFFcspplpEhslpFcp.lclsEp-acpLlt..s.hpthtst......tlhh-.a.Yhp.ssthlKl.lpYh+css.KIhlhEIphaRc.	0	0	0	0
+6947	PF07119	DUF1375		Protein of unknown function (DUF1375)	Moxon SJ	anon	Pfam-B_15247 (release 10.0)	Family	This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the Class Gammaproteobacteria. The function of this family is unknown.	20.30	20.30	22.60	22.30	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.65	0.72	-4.15	41	1264	2009-01-15 18:05:59	2003-08-27 13:05:19	7	3	710	0	129	455	12	66.60	48	72.28	CHANGED	L..lssh....hLsGCuolhohs.ssppsh................hYsGsphshphhpt.................shhhhslshlDLPhShllDTLLLPashh	..................................................h.h.....h...hLuGCuSlhS+ThstpGp.....................YPGsphssp.hu.....................................+.lsILDlPFShVhDTLLLPhDl.a....	0	10	27	78
+6948	PF07120	DUF1376		Protein of unknown function (DUF1376)	Moxon SJ	anon	Pfam-B_15380 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.	21.20	21.20	21.30	21.20	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.77	0.72	-3.85	24	221	2009-01-15 18:05:59	2003-08-27 13:08:51	6	4	156	0	60	198	23	86.00	31	30.39	CHANGED	sa.aphaluDalp-..TtaLostEcGsYhhLLstha.....ps.ppsls.sDcthLsRlstspscc.tsshshllspF...ptpcspatpcRh-cEltph	.............sa.hphaIuDal.s-..Th+L.S..s.pE.+GsYhhL.hhpYa.....ps..scPlP..ppspLA+lsph..oscca...tsshs.lhc.F...htpsstahp.tRh-c-lst.h.........................................	0	9	29	42
+6950	PF07122	VLPT		Variable length PCR target protein (VLPT)	Moxon SJ	anon	Pfam-B_15500 (release 10.0)	Repeat	This family consists of a number of 29 residue repeats which seem to be specific to the Ehrlichia chaffeensis variable length PCR target (VLPT) protein. Ehrlichia chaffeensis is a tick-transmitted rickettsial agent and is responsible for human monocytic ehrlichiosis (HME). The function of this family is unknown [1]. 	20.20	20.20	23.80	24.30	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.11	0.72	-4.28	4	120	2009-01-15 18:05:59	2003-08-27 13:17:43	6	4	3	0	4	113	3	29.60	65	67.36	CHANGED	DLQQSSsSDLHts.pVEL.sPSKEtVQLEs	.....DLQQSSsSDLHtS.pVEL.sPSKEtVQLEs	0	4	4	4
+6951	PF07123	PsbW	PsbW_2; 	Photosystem II reaction centre W protein (PsbW)	Moxon SJ	anon	Pfam-B_15117 (release 10.0)	Family	This family consists of several plant specific photosystem II reaction centre W (PsbW) proteins. PsbW is a nuclear-encoded protein located in the thylakoid membrane of the chloroplast. PsbW is a core component of photosystem II but not photosystem I [1]. This family does not appear to be related to Pfam:PF03912.	25.40	25.40	26.20	29.20	22.70	25.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.90	0.71	-4.11	9	66	2009-09-11 00:41:56	2003-08-27 13:39:30	7	1	36	0	30	63	0	117.30	50	97.19	CHANGED	MsuluAsus....splsu+uhstssthhssh.s.sshslPuhps++...hhsshppc..hhpsh.....s.tsuhhussuu.hs....utPAhALVD-Rhss-GTGLPLGlssshLGaILhGVFshIWuLYhlhs+s....lp..cD-DS.GLuL	...............................................................shGLPthtttt..tlpCshppc.t..t......huh....uuuhhAAsuuhhs....usP.AhALVDERhSTEGTGLsLGLSNNLLGWILlGVFGLIWuLYhlYoSs....L-....ED--S.GLSL...........	0	7	21	28
+6952	PF07124	Phytoreo_P8		Phytoreovirus outer capsid protein P8	Moxon SJ	anon	Pfam-B_15606 (release 10.0)	Family	This family consists of several Phytoreovirus outer capsid protein P8 sequences [1].	21.20	21.20	556.10	556.00	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.40	0.70	-5.82	4	19	2009-01-15 18:05:59	2003-08-27 13:57:44	6	1	8	13	0	19	0	423.20	64	100.00	CHANGED	MSRQsWlETSALlEsISEYlV+s.GDTFpGLThsDloTLSNLhsQLSlusVGFLND.RTPLQsMSNpFVsFISTTDRCuaMLp.sWFDSDltPsV.TDNFIssYIKsRhSsPlSDslRQlNNLSLpPpts.KlhSpQNAlhKALD.PYuoPl-PpcLhRuoAst.sGNhspRRuLsTsLstGAps.sFhVuE+c+IlFGpRS.NslsAupYpINVPsaaSsLsVTsARlYFTNSFlGsTIsNVpVNA.NGsssVAsIpVPTDsNshsVDSDulVSFSLuGGsINVsTuVshTGFAIAIEG-FphQMNRsQSYYThsSITh.sslsIDDFGlosaLEsFR.RLhACGQsEIFS-uMNpLT.sLIsNYhssstssshlAFsSPWYRhSERhtTILoF.ptslsLppR+LhVRHLWVIhSFIAVFGRYYssN	MSRQAWl-TSALlEsISEYss+CoaDTFpGLThsDhssLSNLhsQlSVuSVGalsDPRsPLQsMSspFVsFISTsDRpuYMLpKsWFsSDltPsV.oDsFIATYIKPRhphshSDVLRQlNNhALQP.tsPKLIsRQ.uVhKuhDIPYSTPIpPpDlhRSsAss.sGNVuphthLuTP.l..AQNsTFhVuEpc+IlFGhRShssIssGNaQIsVPPWhSsLsVssARlYFTNSFhGsTItsVpssAVsGsDsssTlTVPTDsNshlVsSDSVVSLSLuGGsINVThuVshTGasIAIEGcFsM.hNtS.uYYTLoSlTh.sss.IDDFGLSAFLpPFhhpLRAsGQsEIFSpuMNsLTpsLIppYMsAstAss.IAFsSPWaRFSERARTILsh.tsllshssRKLIIRHLWVIhShIAVFGRYYpsN.	1	0	0	0
+6953	PF07125	DUF1378		Protein of unknown function (DUF1378)	Moxon SJ	anon	Pfam-B_15650 (release 10.0)	Family	This family consists of hypothetical bacterial and phage proteins of around 59 residues in length. Bacterial members of this family seem to be specific to Enterobacteria. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	25.90	44.70	21.50	17.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.86	0.72	-4.02	3	166	2009-01-15 18:05:59	2003-08-27 14:01:00	6	1	103	0	3	53	0	58.30	75	98.88	CHANGED	MTFVpplLLYFCTVVCsLYLVSGGYKVIRNYIRRKIDcAAAEKISASQSAGSKPEEPLI	.MTFlpplhLYFCTVVCsLYLlSGGY+AhRDaWRRQIDKRAAEKI.SASQSAGSKPEEPLI..................................	0	0	0	3
+6954	PF07126	DUF1379		Protein of unknown function (DUF1379)	Moxon SJ	anon	Pfam-B_15837 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	25.00	25.00	31.00	30.90	18.70	18.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.63	0.71	-4.84	33	709	2009-01-15 18:05:59	2003-08-27 14:03:06	7	1	704	0	77	265	9	154.00	63	85.88	CHANGED	hLcLuscMlFposaptKhLlssAhspstFsV-DAuhYhpahEpl.sp.lslocsppsplsLNAsAApRFhKPhMPKSWaFpsp..stsh.PppGclhp..LpsstppuphlVlEsu-pAoLChLls.pphtLsssKslt.h-sIKVMpDRltPhpst...hph	.....MLDLANGMLFRSRFuRKMLTPDA..FsPsGFCVDDAALYFSFEEKC.RD.hsLSKEQ+A.ELVLNALVAIRaLKPQMPKSWHFVuH...GchWsPhsGDAAsVaLSDTtEQVNLLVVEs..GENAALCLLAQ.PsVVlAG.RsMQLGDAIKIMNDRLKPQls.....hssh..	0	6	22	48
+6955	PF07127	Nodulin_late		Late nodulin protein	Moxon SJ	anon	Pfam-B_15657 (release 10.0)	Family	This family consists of several plant specific late nodulin sequences which are homologous to the Pisum sativum (Garden pea) ENOD3 protein.  ENOD3 is expressed in the late stages of root nodule formation and contains two pairs of cysteine residues towards the C-terminus which may be involved in metal-binding [1].	29.90	29.90	30.10	30.00	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.15	0.72	-3.84	92	434	2009-01-15 18:05:59	2003-08-27 14:53:18	6	9	8	0	2	491	0	55.00	33	72.20	CHANGED	MucllK..FVYsh....IlFlSLFLl.stsss.........hhtCpsDsDCPph.......hs.hhh+Cl.sthCp	...............MscllK..F.VYsh....Il..FlSL.FL.l.sp.ssp.................hhtCpsDs.DCPph.........h.hs..hhh+Cl.p.thC.....................	0	1	1	1
+6956	PF07128	DUF1380		Protein of unknown function (DUF1380)	Moxon SJ	anon	Pfam-B_15699 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 140 residues in length. Members of this family seem to be specific to Enterobacteria. The function of this family is unknown.	21.40	21.40	21.70	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.76	0.71	-4.36	3	549	2009-09-11 02:05:09	2003-08-27 14:58:00	7	2	244	0	12	281	0	130.40	49	93.64	CHANGED	MYGTCETLCRhLsEQYPAETPLNLIIWSPADIEALADGMEYSlSEHDlRAVLARMDsIPEEQRLESGVSAGAVM-LI-QVKENsptVTVPADLLETLLpTAEQALW+REWTARD+NLPVPESVTRRLADsAKVRALLKs	..........MYsTscplhR.t.LsschPsspslhhVlho.t-lptl.Ap...DhSLoDcElcTVhtRL-Dh.E...ctts-suI.sp...ssVh.Elhpp.hp...c.s.......RQVTVPA.hLtplhthAtp.h...........................................................................	0	1	3	9
+6957	PF07129	DUF1381		Protein of unknown function (DUF1381)	Moxon SJ	anon	Pfam-B_15743 (release 10.0)	Family	This family consists of several hypothetical Staphylococcus aureus and Staphylococcus aureus bacteriophage proteins of around 65 residues in length. The function of this family is unknown.	25.00	25.00	34.70	42.70	24.90	19.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.95	0.72	-4.56	6	367	2009-01-15 18:05:59	2003-08-27 15:00:33	6	2	205	0	9	129	0	43.80	83	63.12	CHANGED	pQYLITpFpDSTGpsHscls+AR-NpohTlVEAESKEEAlcKYc	.TQYLVTTFKDSTGRpHTHIT+AKsNQpFTVVEAESKEEAKEKYE.....	0	3	3	9
+6958	PF07130	YebG		YebG protein	Moxon SJ	anon	Pfam-B_15760 (release 10.0)	Family	This family consists of several bacterial YebG proteins of around 75 residues in length. The exact function of this protein is unknown but it is thought to be involved in the SOS response. The induction of the yebG gene occurs as cell enter into the stationary growth phase and is dependent on  is dependent on cyclic AMP and H-NS [1]. 	27.50	27.50	28.10	40.00	27.20	27.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.47	0.72	-4.29	32	761	2009-01-15 18:05:59	2003-08-27 15:05:55	7	1	755	5	92	274	16	74.10	64	75.84	CHANGED	MAVhspYVV.R-GhE.......KMTFsSKKEADAYDKMLDlADsLsshLppusltl-EsptEpLuhaLAppK-sltphLKus	.....MAVEVKYVV.l.R-GEE.......KMoFTSKKEADAYDKMLDhAD......lLssWLs..pSPl..th.--pQREuLSLaLAEpK-lLusILKs.u..........	0	16	31	64
+6959	PF07131	DUF1382		Protein of unknown function (DUF1382)	Moxon SJ, Eberhardt R	anon	Pfam-B_15770 (release 10.0)	Family	This family consists of several hypothetical Escherichia coli and bacteriophage lambda-like proteins of around 60 residues in length.  The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	34.00	33.80	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.82	0.72	-3.87	2	320	2009-01-15 18:05:59	2003-08-27 15:09:15	6	2	199	0	0	80	1	48.90	76	93.40	CHANGED	Mp+ASPs-LRpslEhAp.LAp.GlRFVPIPs.TDtEFtTLus.hupKlE.hAAcAEhpEpp	....................................PIPVETDEEFHTLAsSLSQKLEMMsAKAEA-ERD..........	0	0	0	0
+6961	PF07133	Merozoite_SPAM		Merozoite surface protein (SPAM)	Moxon SJ	anon	Pfam-B_15860 (release 10.0)	Family	This family consists of several Plasmodium falciparum SPAM (secreted polymorphic antigen associated with merozoites) proteins. Variation among SPAM alleles is the result of deletions and amino acid substitutions in non-repetitive sequences within and flanking the alanine heptad-repeat domain. Heptad repeats in which the a and d position contain hydrophobic residues generate amphipathic alpha-helices which give rise to helical bundles or coiled-coil structures in proteins. SPAM is an example of a P. falciparum antigen in which a repetitive sequence has features characteristic of a well-defined structural element [1,2]. 	24.30	24.30	24.30	24.30	24.20	23.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.24	0.71	-4.37	4	426	2009-09-10 23:03:07	2003-08-27 15:43:46	6	3	6	0	17	335	0	156.00	42	29.44	CHANGED	GWEFGGGs..sp.tssEcKKpc.lLEplploSWDKEsIsKENEDVh-EhpE-s---EEc.p.............EElEEsE-.-sEpEllE-c.pEEE...c-E-sscpc-.EKcspN-lss.........p.pD.pAQsLISpp.KcN-cs.KKoAEsllpsLhuLlpspNplDuTl+cLhpEhhcaFsNp	................................pKcc.hLEhlploScDcEsIsKcNED.V+EEhEEptE-p.EE.--p...................E.ElEpp...p-EE.T-E.EssEEcp.EEpE.....p...cc-.EE..sc.c....c..c.....p.p..EK.c..s.Ncpps................p.t....o.cpD.cAppLI.........Sps.KsNs-s.KcsAEoIVKoLhuLhpttst...s...................	0	6	6	15
+6962	PF07134	DUF1383		Protein of unknown function (DUF1383)	Moxon SJ	anon	Pfam-B_15868 (release 10.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 375 residues in length. The function of this family is unknown.	25.00	25.00	48.50	48.90	18.00	17.00	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.24	0.70	-5.52	18	40	2009-01-15 18:05:59	2003-08-27 15:58:01	6	1	36	0	0	42	0	313.60	31	85.79	CHANGED	-plhpQlap.tslPYIoKKtlNDpLpsplhtp............................sstpFaccsacsVhssh..sshhVlpGGAAhAsHlsst..psh...L...psLDh-hYht......................sshpp..alpLspLpccLp.ssspshhcslspllpslch..h..........................psslllhKsY.NtAlch.s....ssVphcLsc+...lKsshophN...--ahLVRFShNVcM..hS..tsu.lc.Yps.p.hlpphshhsFsVaFlslplh.....+pPh..s-......hphhslFsss.....VhVpslcpllsDQlpCLLaslF.s+sphKlcpRhspIpuLhsphspp.shssshpscc...hhtl.+ppspshohpplKclLhhhGPtLGs+tL	.......................................................................-plhppLa..tslPYIoKK.INDpLpcplltp............................sstpFa+cshcsshtsh......sshhVlpGGAAlAsHlspp.pst......LpslDh-hY..............................sshpp..hltLppLp.cpLp.pssppaasplcplhtslph.............................psplllhKsY.NtAhchs....splphcLNc+...lKsshoplN.......--ahLVRauhNVcM..pS....tsshh.aps.pshhpshshhsaslaFlslplh.....+pshshsc.....shphhslFGhs.....VhVpslcpllsDQlcCLLhslF.Np.paKlcpRls+lpsLhs.hsp..shso.shpppp...hhpl.+pps.pphohpplKplLhhhGPtLGs+tl.......	0	0	0	0
+6964	PF07136	DUF1385		Protein of unknown function (DUF1385)	Vella Briffa B	anon	Pfam-B_12671 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 300 residues in length. Some family members are predicted to be metal-dependent.	22.10	22.10	26.10	24.40	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.67	0.70	-5.29	57	654	2009-01-15 18:05:59	2003-08-28 10:03:17	6	3	631	0	173	542	224	241.30	41	75.66	CHANGED	lPhlRGhhsLh-ohslGh+sLsaSAshhtt-......t................................p-c..hsphthhhol....llShshulsLFhllPshlus...hh..p.h....h...sphh.hsllEGllRlslFl...sYlhhIShh.cDIcRVFpYHGAEHKsIpsYEsGt.LTVE...NVp+aSplHPRCGTSFLhhVhllSIll....Fshlsh...........tshhhRll..RllLlPlVuGloYEll+hsu+pps..ls+lluhP....GLhLQp.LTT+EPDDsQlEVAItulctsl.s.cp	.........................................................................lPFlRGlsull-uhshGhKpLsaSuphhtt-.....pp....................................................................c-c.hsph..thslsl.........llShlhuhslFhllPshluphh.....p.h........hs...sphhhsllEGll+lh.lhl...sY...Ih.hIShh..-I+RVFpYHGAEHKsIpsYE.sshtL.TVE...NVpK.oRLH.R...CGTS.Fl.lhlh..llulhl....a.h..l..lsh...............ssl...hhRllsRllLlPVVsGlSYEl.l+hsu+hcs..sll+lLuhP....GLhLQh.L.TT+EPcDcQlEVAIsuhctllt..p........	0	90	146	160
+6965	PF07137	VDE		Violaxanthin de-epoxidase (VDE)	Vella Briffa B	anon	Pfam-B_12679 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within plant violaxanthin de-epoxidase (VDE). In higher plants, violaxanthin de-epoxidase forms part of a conserved system that dissipates excess energy as heat in the light-harvesting complexes of photosystem II (PSII), thus protecting them from photo-inhibitory damage [1].	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.45	0.71	-4.47	7	98	2012-10-03 08:47:39	2003-08-29 13:30:32	6	4	50	4	43	95	4	180.50	60	51.01	CHANGED	EFNECAVSRKKCVPpKSDVGEFPVPDPSsLVpNFNMtDFsGKWaIoSGLNPTFDAFDCQLHEFHhEss.KLVGNLoWRI+TPDuGFFTRoAVQ+FVQDPsQPulLYNHDNEYLHYQDDWYILSSKIENKPDDYIFVYYRGRNDAWDGYGGAVlYTRSssLPESIlPELp+AApSVGRDFssFIRTDNTCGPEPPLVERl	.................................................EFN-CAVS+KKCV......PpKuDl..G-FPVPsPssLVcsFNhsDF..s..GKWYIoSGLNPTFDs.FDCQLHEF+.s.E.s.s...K..LluNLoWRI.c.....TP...D...uGFFTRoAlQ.+FVQ..DP.s.pPuI.......LY........NH..DNE..a...LHYQDDWY....IlS.SKl....-Nc.DD...YlFVYYRG+N.DAWDGYGGAVlYTRStsl.PcSIlPELc+AAKpVGhDFsp.FlcTDN...TCGPEPsLhtRl............................	0	20	35	40
+6966	PF07138	DUF1386		Protein of unknown function (DUF1386)	Moxon SJ	anon	Pfam-B_16196 (release 10.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 350 residues in length. The function of this family is unknown.	21.40	21.40	23.00	95.40	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.09	0.70	-5.31	8	20	2009-01-15 18:05:59	2003-08-29 13:55:16	6	1	18	0	0	19	0	319.90	47	97.50	CHANGED	MSLSSKLLVYAYYG.sYNhsHc+YGESYHLYRIVcE+Los.....oYVsssSCVRRDIsTARpL..ssGtlsF--ARphLDls-sAspLosWYpsG-.ooGlCu-VQpVLspIDpasPL-+RVppGu.........sIauLDs.hs-Isp-hsssLQslIGR.FhHFsRsssLsHVA-VFDPs..l+ssGWWYpKFCVLTYMHRlhssuVPsELhsRLpcAVsKaI+Ps...........DcuNCA.AlAsVYGRFCGIGR-HFu+HKsssh+ILFQYMRuchT.ssERassFuVIKDFGRpCKETYpDL+spADsLYIpuoTD+pKNALFDLLCCsNAs-IDsDCYDYIV...spFYs	...........................................................MSLuuKLlVYsYYu.pYNtsHchYGESYHLYRIVpEaLoc.....SYVsshSClcRDlssARRL..psGshsFD-AhphlDss-oscpLSpWasT.G-..opGlsssVppVLppIDshsPlshRVppG.t.........pIFuL-s.........pEIsp-h....sDsLQhllGR.FhaFhRsspLh+lAsVFsPs..tcs...sGWWYsKFCVlTYhHRIhtpuVP...sELh.sRLpcAVpKaI+.p..........t-phNCscslA-lYGRFCGIG+EHFu+HKhsCh+ILFQYlR.GcsT.p--cFsCapVIKDFGRpCK-sYcsL+shhDhLahauhoDKcKNuLFDLLCshsspEIDlDCa.YIh...cpFh....	0	0	0	0
+6967	PF07139	DUF1387		Protein of unknown function (DUF1387)	Vella Briffa B	anon	Pfam-B_10471 (release 10.0)	Family	This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.	25.00	25.00	25.60	25.20	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.10	0.70	-4.81	6	164	2009-01-15 18:05:59	2003-08-29 15:07:34	6	4	51	0	64	117	0	236.20	51	55.81	CHANGED	WoVTGKK.KNtKKKKsKsKscusspsA....t+..shs.ppssPss-.cs.sNGaHsNGuth.DoESlDSLSEtL-ohSLDA+E...scssh.-hsspsssshpsG.sch.ppK..hpssPcuopss.......p.stt..sp.pp..t.ss.hhpp............hu+KhusNIE+SVKDLQRCTsSLuRYRVllKEEMDSSIKKhKQTFAELpSCLMDREVALLAEMDKVKuEAM-IL-sRQK+AEELK+LTDhAupMoEEQLsELRADIKHFVSERKYDE-LG+AsRFosDlEsLKpSIpoaGpVsHPKssYSsRot.CS	....................................................................................................................WshTGKK.KN.K+K+sKsK.tttspsu....p+..sh..p.tss..p......NG....+hNGs.p.DopSsD..ShsEt....ul.sRE......c...uh...-....spsh...p.hlppu...t.h....p.+..h......tt....ps.pt...............p.s..tt.t.s.p..s.....thss.h.ps..........................................thsKKh....G.sNIEKSVKDLQRCTVSLsRYRVhlKEEhDuSlKKhKtuFAELpsClhD+EVuLhAEMDKVKtEAMEILhuRQKKAE.LK+hTDlAspMuE.QLsELRA-IKHFVSERKYDE-LG+sARFoCDlEpLKtpI..hGpl..oHPKNsYSsRo..C..................................................	0	9	14	26
+6968	PF07140	IFNGR1		Interferon gamma receptor (IFNGR1)	Moxon SJ	anon	Pfam-B_15930 (release 10.0)	Family	This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta).  The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection [2]. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac Pfam:PF01108.	20.70	20.70	25.70	24.80	19.30	18.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.26	0.71	-4.45	12	134	2012-10-03 16:25:20	2003-09-03 09:36:26	6	2	72	6	18	111	0	134.40	36	41.50	CHANGED	YsptshCshhhhYsshhpascopph...pYslc-p.CspstCplshsop...pplCVos.Gspps..h...pT-tSp-VCls.h.....................ssth.VsshhlKphsDlpphpptls+slpp+hcppop.t+..phY.shlsshhtthlp..............................-	.......................YccpshC.hhhlYss.hphscScEsh......pa.slc.-..DCspTtCplshsso...pchCVoApGsocsah....hT.hS.pEVCl...........................s.phsVhsCh..I+phpslpp.hp.ths+sl.hphhpp....top..........................tthh...........................................................	0	1	1	3
+6969	PF07141	Phage_term_sma		Putative bacteriophage terminase small subunit	Moxon SJ	anon	Pfam-B_15957 (release 10.0)	Family	This family consists of several putative Lactococcus bacteriophage terminase small subunit proteins. The exact function of this family is unknown.	22.80	22.80	23.10	28.50	19.60	22.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.07	0.71	-4.71	2	45	2009-01-15 18:05:59	2003-09-03 09:51:03	6	1	44	0	0	19	0	172.70	91	98.00	CHANGED	MQTQpGGRPTILPKMYEEPLFSQIIDKIESGCNDREIYTSLHCSAKTFRKWRDDNIKAYDEAKGIARGNLLELAESALASKLTVRTLKETETIYDADGNVEKVKVKEKELDKDSLVAMMVAKAGNPELYNPTEWRRLQQEESSAHDLKAKIEELDDYKLSKYcTPcIEVPcGFE	...MQTQNGGRPTILPKMYEEPLFSQIIDKIESGC.ND.REIYTSLHCSAKTFRKWRDDN...IKAYDEAKuIARGNLLELAESALASKLTVRTLKETETIYDAD.GN.....VEKVK.VKEKELDKDSLVAMMVAKAGNPELYNPTEWRRLQQEESSAHDLKAKIEELDDYKLSKYETPKIcsPEGFE................................................	0	0	0	0
+6970	PF07142	DUF1388		Repeat of unknown function (DUF1388)	Moxon SJ	anon	Pfam-B_16000 (release 10.0)	Repeat	This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo [1].	25.30	25.30	25.30	25.30	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.43	0.72	-4.23	28	466	2009-01-15 18:05:59	2003-09-03 10:27:34	7	28	45	0	52	575	2	29.10	50	24.82	CHANGED	PspsKoPuEsKoPs-sKoP..uEsKoPscpK	...............PscsKSPscsKSPscsKSP..scsKSPsctK......	0	5	5	7
+6971	PF07143	CrtC		Hydroxyneurosporene synthase (CrtC)	Moxon SJ	anon	Pfam-B_16004 (release 10.0)	Family	This family consists of several purple photosynthetic bacterial hydroxyneurosporene synthase (CrtC) proteins. The enzyme catalyses the conversion of various acyclic carotenes including 1-hydroxy derivatives. This broad substrate specificity reflects the participation of CrtC in 1'-HO-spheroidene and in spirilloxanthin biosynthesis [1].\	     This family also contains the members of the old Pfam family DUF2006.  Structural characterisation of DUF2006 family member Swiss:Q82US3 has revealed a lipocalin-like fold with domain duplication.	26.20	26.20	26.50	26.30	25.60	26.10	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.18	0.70	-5.13	69	733	2009-01-15 18:05:59	2003-09-03 10:38:50	6	6	601	2	267	685	396	285.70	23	77.79	CHANGED	hEWWYlsAphps....GpthssphshhtsshsP...................t.sstphhhspsAlh..........ssppphhhcchuRuu..lup........sssshpsh.......h-saphpups..................hslplstsutpht.........lclplpspss.hlh.sptGhoh+s.sts.....p.Auahau..tPhhplpGslsh.sut..php.........lp.......GpuWhD+pauo.......psLsps.suWDWhsh.....plss..Gps....LhhaplRppss.........................satsushhhss.Gps....h....s.ttlphps..hthsss.suhphPhtWplch.....ssps....lslphpslhpsu.h....ssshsYa......EGsltlptshs..........uhuahch.pGh	................................................................................................................................EWWYhsu.lp........stt....G.p.huhQhshhR.sht.....................................t.ssa.ts.plhh....uphul.s..........sttt...hhh..tp+huRsu.........hu.....Ash...........sspshphh.......lc...s.Wphputs.........................hshplph....ssp..shs...........................................lpLpl...ps...ptP....lhpGppG.hshKs..s.s........t.ASaaao........hPhhp.l...p...Gslsl..sup.......shp..........................Vp..................G.p.u.WhD+...EW.......uo..................phL..s...sst...p.GW.DWhsl.....pLss....Gpt......Lhha.p.lRppss.........................sh.htushh...ss..s....Gps......l.....tspplphps.........h.....phs..........s...........sst.p..hPh........t..Wplpl....sshs.........lslplpsl..tst.h........shth..sYW........EGs...lt.lp..G.sh.p..............uhGahch.oGY............................................................................................................	0	67	142	211
+6973	PF07145	PAM2	Ataxin-2; Ataxin-2_C;	Ataxin-2 C-terminal region	Albrecht M, Studholme DJ, Vella Briffa B	anon	[1]	Motif	The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for Pfam:PF00658. It has been found in a wide range of eukaryotic proteins [1]. Strikingly, this motif appears to occur solely outside of globular domains [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.47	0.73	-6.31	0.73	-4.08	53	834	2009-01-15 18:05:59	2003-09-03 11:18:39	10	35	156	12	410	759	0	17.60	49	3.57	CHANGED	stpSpLNPsApEFVPsst	.....hpSpLNPNApEFlPss....	0	62	129	229
+6974	PF07146	DUF1389		Protein of unknown function (DUF1389)	Moxon SJ	anon	Pfam-B_16027 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins which seem to be specific to Chlamydia pneumoniae. Members of this family are typically around 400 residues in length. The function of this family is unknown.	21.50	21.50	21.50	30.10	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.86	0.70	-5.37	15	75	2009-01-15 18:05:59	2003-09-03 11:21:53	6	2	13	0	20	46	1	296.70	27	70.81	CHANGED	shslslslSlllsuluhslhlhshhpthh.............ptpsIPpG...........................FpplI+cpYPcslaclVhpppLolpElRhllsuL...........ppshsphspcL+pKlcsF.Gl-pLpsshcstcL.............ssL-clLlcNCPLYWLp+F..IclGs+phs.........pssp........hpsssYWlu+lGh.......usstsTIFs.psalluplloc-EYphLhsHA+NsTWspsc..VpslppRl.hshlspthtttpcpspsplsp.....hhpcth.shLLtLCpHGlSW-QLQLlcplsscphsFLstl...-pup.hsstlpphshuhhs.t........alsEss.p.F-PsluLhTacEa+	........................lshhluhhhssluhslh.hshht.hh...............p.IPpu...........................applIpppaPpslhshlhpppLolpElRhllpsl.............psshsp....hsppL+p+lpsF.GlcplpsshpuhsL.............ssL-slLlppCPLYalp+F..IphGs+pl..........ptpt........hp.ssYWlschGh.......ssstsTIFp.hsalluphlSccEY.hLhp+Acss...s...Wsptp..VsulppRl..t.htphhh...ptcpshsphhs.......hhpc..tphLLhlCpHGlSWEQLQLl+pls.hcshtaLstl...-pus.hsttlpphhhshhs...........ahsppspp.a-spluLhTasEh........	0	0	0	18
+6975	PF07147	PDCD9		Mitochondrial 28S ribosomal protein S30 (PDCD9)	Moxon SJ	anon	Pfam-B_16045 (release 10.0)	Family	This family consists of several eukaryotic mitochondrial 28S ribosomal protein S30 (or programmed cell death protein 9 PDCD9) sequences. The exact function of this family is unknown although it is known to be a component of the mitochondrial ribosome and a component in cellular apoptotic signaling pathways [1].	25.00	25.00	28.20	25.70	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.37	0.70	-5.70	14	222	2009-01-15 18:05:59	2003-09-03 11:37:19	7	2	90	0	141	204	0	322.20	25	75.44	CHANGED	Mushpt...hp.l.............ttt....s.p.pp.ss.....sssshYPPIh.opshps+us+p+phcpa...................httlptssslcEKl.hhsthph................+ahsa......PpshshNu.caaQahTKTsh.suLP...s.t...............................................ptp..shschhhutlcshhpthhLQcpaappccc..........cppchsst.hLspLspslhshLupp.stLspsplDhsPplphaWsRGtph.s.........+shp+th.cshcaQlDD.............+PthplRhpppLs.ahs.-tp......hstclPshc.........acPptLsLapcpacsth.ssuhhs...ssssaGhspFphhschhpR...........cp....s.tsQhEs.h+ApuIhShFAWhsAQA.hYpGFhstsDlTcPhsoQsVITDG+haSFaCYQLNTLuLsspsst.sNsRpNhsWGTpuh.LY-p...............l.pcsclhGaN-.....sslppllpFhlNps	.......................................................................................................................................................................................................................................................................................................................................................................................p....hps...h.hhT+Thh........t.L.P.............................................................t...t.hp.h........h...t.................................p......hltpl...hht.h....p...........s.Ltt.t..h.s.p....hthhW.htt...................................hQhps....................pst.tlphtp.Ls.hhs.p............hsh.l..sh..............................s..shls.l.ppp.h.p...h..suhh...........s....hsas.as..ahhh..s.t.....hR...................................................tt.ht..s.h+ApsIhtsFuhshA....pA..th..G...........hps..ps...ls.pPhlsQuV.hTDG+hFpFhsaQLNTlsLss.....ss....s....hKNlsWss.p..sh.LYpp....................................l..pss...t...hhshps.....cshhphlthhh.............................................................	0	45	57	101
+6976	PF07148	MalM		Maltose operon periplasmic protein precursor (MalM)	Moxon SJ	anon	Pfam-B_16111 (release 10.0)	Family	This family consists of several maltose operon periplasmic protein precursor (MalM) sequences. The function of this family is unknown [1].	19.50	19.50	20.60	19.60	18.10	19.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.33	0.71	-4.71	36	702	2009-01-15 18:05:59	2003-09-03 11:41:22	7	2	687	0	64	315	6	135.60	62	45.04	CHANGED	sstpShhAAaplP..uspGshplpLoShl..spslFsPsVllLDpphpssphhssspFpYp.sshhsssRlpuplpls....s.uppphYlllYToppDLstoTpl.cP..AKshAcuhGpshPtlsDssstHossGplclplp	..............................sGIoGPVAAYSVP..ANI..GELTL...TLT.....SEV....NKQs....SVFAPNVLILDQNMTPSAFFPSSYF..TYQcPGVM.SADRLEGVMRLT...PALGQQKLYVLVFTTEKDLQQTTpLLD.P..AKAYAK.GVGN...ulPDIPDPVARHToDGllKLKVK..............................	1	8	22	46
+6977	PF07149	Pes-10		Pes-10	Moxon SJ	anon	Pfam-B_16134 (release 10.0)	Family	This family consists of several Caenorhabditis elegans pes-10 and related proteins. Members of this family are typically around 400 residues in length. The function of this family is unknown.	21.10	21.10	22.50	22.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.19	0.70	-5.69	5	17	2009-01-15 18:05:59	2003-09-03 13:21:49	6	2	5	0	17	15	0	278.90	21	92.35	CHANGED	MNcTEYphHLLARTI+TGcDEhITPlIpQLs-hpVSMDILEKHNlPsLVscaAPaNpsApSLu+slLsWKN-clppEKPplLKcFsctst-c+aP-pFV....L+LLTuLMsF-DL-LV+ssFcILsph-LoL--aEcaGIaE+AtpFQtQhcEADELIsKl-..hLpsEhLEEsEpEpptsclhssh-cc...................u-sESGlFT--E..........cccspcp.llhEICMlaLApCIKoGNs-VISuAIpFsGsacaPLALYRKYDIQhLIYsaGs+s-DAcpLhDaIEclEclElssE+lEAFK+Fl+..sshEp.csVTDSVMolLpGFL........E-sDDahVcsTLcFFLsMPISL-QFcps+VEssLcNLEptssupLullLKhKIp-L+p	...........................Msthph.h.hLA.hltst..p.t.Io....hhp.......L.s.h....hchh-ptNhPhllt.....p.ss....A.ph...hh.hK..phtpE...hhptFht....hh........tt.h...............lpLhh.h........t..p..hhp.sh.hl.t..h.ht.h....h...h.....ph.-t..lh.p..............t.......-..............................................................................................-l.hh.hht.lpstspthls..............hulph...htt.phsLplhpKY-IttLlh.ths.p.pptA.p....Lh.pIpphpp.tht.pp.phh..hhp........t...sshht.h..ah.....................................................................................................................	0	6	7	17
+6978	PF07150	DUF1390		Protein of unknown function (DUF1390)	Moxon SJ	anon	Pfam-B_16182 (release 10.0)	Family	This family consists of several Paramecium bursaria chlorella virus 1 (PBCV-1) proteins of around 250 residues in length. The function of this family is unknown.	20.00	20.00	20.20	20.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.53	0.70	-4.99	25	54	2009-01-15 18:05:59	2003-09-03 13:27:10	6	1	10	0	3	52	2	190.20	31	82.66	CHANGED	csaphslYpCuCGYcTsssuNAoKHKKT.uCsHchpscpc.cFVLcEDh...phtsspshsstshsssss.ssshsphlsp.psIsIsLslP-poshssIh-slps.phhpElcsu.-PppIPAlLF+aTRGht.....utpphI+Y-sDKslVpcKDP.sG+-sspcLKKY+scYls-sssla-cshclsahPpplpcsh+-hppPphssG+KKsc.lsuA-slKhsAoGsHhhYKhPtE	...chaphplYhC.s..CGYcThspusAs+HpKo..pCtcc.hhpppp.pFlhcc-h...t...stsh......t.sshtt...s.pp.lp...phshsLhlP-tshhpslhchlps.ph.p-lpst.pspphPullachT+u.t.....tt.thlphcsDK..lhctc..sGp.htpslpKhtpcah.cssshhppsh.l.h.sp.hpp.hc-hppsphs.G+K+sp.lsuu-sl+.hAsGsHhhYKhPhE................................	0	1	1	3
+6979	PF07151	DUF1391		Protein of unknown function (DUF1391)	Moxon SJ	anon	Pfam-B_16216 (release 10.0)	Family	This family consists of several Enterobacterial proteins of around 50 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi where they are often known as YdfA. The function of this family is unknown.	25.00	25.00	32.20	76.00	22.70	21.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.54	0.72	-4.47	4	588	2009-01-15 18:05:59	2003-09-03 13:43:20	7	1	261	0	3	201	0	48.70	87	78.29	CHANGED	pplDLGNNESlVhGVFPNpDGTFTAMTYT+SKTFKTEuGA+RWLtRpss	..DTIDLGNNESLVCGVFPNQDGTFTAMTYTKSKTFKTEsGARRWLtRNo.s........	0	2	2	3
+6980	PF07152	YaeQ		YaeQ protein	Moxon SJ	anon	Pfam-B_16245 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length which are often known as YaeQ. YaeQ is homologous to RfaH, a specialised transcription elongation protein. YaeQ is known to compensate for loss of RfaH function [1].	25.00	25.00	28.00	26.10	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.87	0.71	-4.94	64	1039	2012-10-11 20:44:44	2003-09-03 13:49:14	7	2	1018	5	215	584	86	173.00	52	96.12	CHANGED	MAL+uTIYKsplpluDhDRsaYpshpLTlApHPSET-ERMMlRLLAaALpAs..E.p....LpFTK.GLS.ssDEPDLWpKsLs.scIplWIElGpPDEcRl+KAss+AccVhlasY.upssplWWpptps+lsphcNLsVhplspsthpsLupLspRsMpLploIp-Gplalosspp..s.lpls.ph	...........MALKATIYKAslNlADhDRsha.hDtuLTLARHPSETpERMMlRLLAahhaAc.....ER.........LpFT+.GLs.s-DEP-hWh+s.c.huI-LWIELGlPDE+RI+K..ACs...pA..tc...Vs.LasY..suRAAplWWpQspuKhspasN....LoVahLD--plupLushA-RTMsLQsTIQ.DGslWLSDscs.s.lElphps.................	0	39	107	166
+6981	PF07153	Marek_SORF3		Marek's disease-like virus SORF3 protein	Moxon SJ	anon	Pfam-B_16263 (release 10.0)	Family	This family consists of several SORF3 proteins from the Marek's disease-like viruses. Members of this family are around 350 residues in length. The function of this family is unknown.	21.90	21.90	22.40	28.80	15.70	21.80	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.12	0.70	-5.77	3	18	2009-01-15 18:05:59	2003-09-03 13:53:59	6	2	8	0	0	14	0	263.20	39	91.13	CHANGED	MSRusAslFDDMDIPRGRFGKPPRKITclNFWslLsDELTsGIVQCMESRERLALlHTsSsN-Go.hSFDIHKDMWCQMVLWSAYRFFSTM-+MFSI-oIoNFs-TDVsEoGpW+IaCRTWDlRDAsKMKhlGPFLPALFSFHLENWTTMLSIGIsKGYDRHNsRshFMshPShKNVLlGAlEVARaAVVLoLPICEYRTPhGLPDDpIGNAIKLCCAQMQANRLEcTGIopDutpKsNDuSEEELYYRslH-LVKouREHCcSsE......sshDlsPTI+cpp.psIphphsSsh.hGhtshuR.hNsGch+Yp+.plhRNhPlRVPRSRLuNSKILQTFRcshsRSsha...l	............sRs.AhhFsshDhPRGRFhpP.h+.sshsaW.hhsDEhspGIhQChEuRERlu.lp..p.spG...paD.phDMWsQhslWSsY+hhthhp+.FSlcplh.hscpslstsu.ath.hpsWDlRDusKh+hlGPhL.AhFShHlENWTshLSIuhstG.asppsphs.hMsh.us+.sslhsuhEVAR.hlVLsLPls-YRsP.GLPDDshGNAI+sCCApMQtpRLpcsths.D....hpsssEEEhYYRslpc....lIpstRcas.ssp.......................................................................................h..............................	0	0	0	0
+6982	PF07154	DUF1392		Protein of unknown function (DUF1392)	Moxon SJ	anon	Pfam-B_16270 (release 10.0)	Family	This family consists of several hypothetical cyanobacterial proteins of around 150 residues in length which seem to be specific to Anabaena species. The function of this family is unknown.	25.00	25.00	172.30	172.20	17.70	17.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.88	0.71	-4.35	7	15	2009-01-15 18:05:59	2003-09-03 13:56:02	6	1	3	0	11	15	0	152.00	43	98.45	CHANGED	Mss.IspLEpCWYlSPPWGpphsPltlsLhE+VYLpos+ohGYCCGVpWppDtW.Ysl.scpshlpsscppIIupGphpshslpKPtFtLG-hV.hcFsscusKpRlILGltLlpsuWhYhVEhhSPsL..............stttsh.pRhuhVp-cDLVpV	MhstIssLEoCWYlSPPWGpplPPltlsLlE+VYLpos+ohGYCCGVpWpc-sWhYsIhsss-IlasocspIIuTGplpsholpKPsFtLG-hV.lcFts-uPKpRlILGl.LlcpsWhYtVEhtSPsL..............opsssh.sRhuhVs-tDLVcV......................	0	0	6	11
+6983	PF07155	ECF-ribofla_trS	DUF1393;	ECF-type riboflavin transporter, S component	Moxon SJ, Eberhardt R	anon	Pfam-B_16301 (release 10.0)	Family	This family is the substrate-binding component (S component) of the energy coupling-factor (ECF)-type riboflavin transporter. It is a transmembrane protein which binds riboflavin, and is responsible for riboflavin-uptake by cells [1,2].	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.18	0.71	-4.53	62	2634	2012-10-03 02:46:00	2003-09-03 14:01:05	7	8	1367	0	389	2679	75	161.70	23	88.03	CHANGED	p..ss+plVhhulhsAlhhllsh.h..lpIPss..so....lplspuhlhlhAhlFGshhGhlsGhlGtsLhDhhsG.Ys.hWhsa.llscGlhGhlsGhhspph..php.......hphhs..llhhslhhlhuhhluhsll..................uhtshltulhuslh.pslsuhlluhhLh..tsht+	.............................t..ps+plshhulhs..Alsl.l.lsh....h.......hp...I.PhP................lp..l.s.s.u.h..l..h..lhu..hla..G...s.h..hGh.......l.......l.......Gh.......l.......u...t.h...lt.....D.....h............h....s.G.....Ys....hW...h....s.......a.......p......lls.....p....G.........l..h.....G.....h....l.........s.........G.....h.....h..t.p.p..h.......ph............................p...h.hs.........hl....h....h.s....l....h..t..l....l.u....h..l...s..tslh..........................................t.ss..h.t...s.....h.h...t.....s......l....h.u.....s....lh....ps.l...s....shl....luhlLh..sht.........................................................................	0	159	250	313
+6984	PF07156	Prenylcys_lyase		Prenylcysteine lyase	Vella Briffa B	anon	Pfam-B_12448 (release 10.0)	Family	This family contains prenylcysteine lyases (EC:1.8.3.5) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the reaction [1]. It has been noted that this enzyme has considerable homology with ClP55, a 55 kDa protein that is associated with chloride ion pumps [2].	21.30	21.30	21.30	21.40	19.80	21.10	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.08	0.70	-5.57	5	325	2012-10-10 17:06:42	2003-09-03 14:06:43	9	14	182	0	225	329	7	298.00	29	68.63	CHANGED	FEEosWalINllKLVWRYGlSsLRM+MWVE-VLDKFMRIY+YQuHcYAFSuVEcLL+ulGtsDalshlppTLpEsLpcAGlSppFlNEhVusVhRlNYGQSsDINAFAGAVSLuuAsuuLWSVEGGNKlVCSGLLptSKuNL.IsuoVpSI.....T+aosNspchYpVsYKssstspSDFYDIVVVATPL..DcshSNIT.FtNFcPPI--hpspYQpTVTTlV+GcLNooYFGs+PhDpFsLusILTTDDuslFhssluIl.....sShRcK.....sscGstVWKlFSRcsLo+sQLccLFpSYshsV+KsW.tAYP+YcsPpppPsFILHD.+LYYLNuIEsAASsMEhSAIAA+NlALLAYcRWNscpDh..IDQcsLhc+LKTEL	...................................................hhshh.+lhW+Y..G.h.t...h+.................hp.hhc...phlpc..Fh.+.l...Y..c..............t...............h.sFps.l.pphh.sh...........G........hhthhptohtc....L.....p.s.G...h.......s.p...pFhp.-lltsshRlNYG.Q.s...s.lsuh.............s..Ghho.hs..s.u.t.s.uhhuVcG.GN.h.l...hpthlp.....t.op........u........sl...l.p.s.p.Vtpl.......................p.ss...s..st........h.tl...........h....p.........s......t.......t.....t......t......t.t..p........h..a....Dh....VllAsPh...p.t.....lt.........s..hp....s.h...p....................a.phhsT.h.h..p...u......l...s..s...phFsh...s..p..hs....t...slhTs..........t.......s.........p........h............h...s.........shh..........................p......................pt.thlaKlFS.p.lp...pp...............lppl.............F......................t...........h........................................s....................p.......h.W............u.......YP..h..h..t...s...........p...h....................s.hhL...ts.....t............l.....aYhsuhE........hh.SsMEhsuluucN.sAh.Lhh.pph......................................................................	1	73	112	170
+6985	PF07157	DNA_circ_N		DNA circularisation protein N-terminus	Vella Briffa B	anon	Pfam-B_12343 (release 10.0)	Family	This family represents the N-terminus (approximately 100 residues) of a number of phage DNA circularisation proteins.	19.90	19.90	19.90	20.10	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.94	0.72	-3.85	9	365	2012-10-10 17:06:42	2003-09-03 14:09:03	7	3	318	0	54	329	4	93.30	41	21.62	CHANGED	h+cthtcASFRGVPFhlEc-p.tssGRRl.hHEYPhRDpshsEDhG+phpphplouhllGcDhhspR-+...Ll-AL-psGsGpLVHPhaGphpVpl	...................................WpcpLtcASF...RGVPFhV.psp..sssGRRlthHEYPhR..Dp.sasEDLG+tspphslsAhll.......Gc.......D.......hhspR-.c...LlsALc........psGsGpLVHPhaGchpVtl.................	0	13	25	43
+6986	PF07158	MatC_N		Dicarboxylate carrier protein MatC N-terminus	Moxon SJ	anon	Pfam-B_16346 (release 10.0)	Family	This family represents the N-terminal region of the bacterial dicarboxylate carrier protein MatC. The MatC protein is an integral membrane protein that could function as a malonate carrier [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.64	0.71	-4.39	5	578	2012-10-02 15:12:49	2003-09-03 14:11:11	6	4	502	0	89	495	47	146.70	43	38.33	CHANGED	MssELloILlLllsFlIATspsINMGALAFAuAFllGolllGLcscElLAGFPuDLFLTLVuVTYLFAIApsNGTlDWLV+sAVRtVRGRluAIPWVMFllAuLLTAhGAluPAAVAIlAPVALoFAs+YRIcPLhMGLMVlHGAQAGG	.........................................................h...pllhl.Al.sluIuIG.a..h.pKIN.IG...llA..Is..Fu.Y...lIush.h..M.........G.l.sP.........K..-..l..l....p.......h..W...P..s..u..l..F...FsIhu..V..SL..F....as.h...A.psN.GTL-hLAp+llYRs.Rs.+..Ps.h.L....P.hll...alhusll.oALGAG..aas..s..hA.l...hs....P..lAlhlCpKh..s.hsP..L...lGAhsl.saGApuGu.........................	1	27	59	69
+6987	PF07159	DUF1394		Protein of unknown function (DUF1394)	Moxon SJ	anon	Pfam-B_16260 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 320 residues in length. The function of this family is unknown.	20.10	20.10	21.10	20.20	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.84	0.70	-5.30	7	319	2009-01-15 18:05:59	2003-09-03 14:55:21	7	7	109	0	197	239	1	249.30	46	56.05	CHANGED	tsphFLDFENAQPTEsE+ElappVstVLpcu-ulLt-LpuY+GAupEIR-AIpNPss.phQEcAWpuVsPLVsKLKcFYEFSlcLEpsL.pLLtuLs......uss.sPppHLE+cQALAKQFAEILHFTL+FDELKMpNPAIQNDFSYYRRTlSRpRlsNh..-sEscVsNEhANRMSLFYAcsTPMLKsLScAToKFVSENKoLPlENTTDCLSTMAsVC+sMLEsPcapSRFps.EETlhFChRVMVGVIILYDHVHPVGAFsKoSpIDhKuCIKVLK-QPssosEGLLNALRYTTKHLND-oTsKpI+	..............................t.phFlDFE.....sApP.o-t.Epplaspl.shVLp-.upslLt...................cLpsY.+.GA.uppI............R..c....A..I..p..s..P..sc..........plQ..E+AWsuVsPLVsK..LKcFYcFSh.+...L.-pslpsLLttLs......ss.h.s.s..ppaLE.cpQALsK....phAEILcFsLpFDELK...MpsPAIQNDFSYYRRsl...S..R....+...l.....s..........s..................-....-.spl.....ssEhAN+...MS.LFa..ApuTPM.LK..sLSpAT...cFVs.-..sp.s.sl-ss.o-sLuThs.s.VCthMlEsscahsphps.p-oh.hshRVMVGhlIL..YDalcs.GAFs+t.u.plch+....ssl+lL...p.t.ps...................tspsLLssL+..aoopHhs.p.sTsttl...............................................................................................	1	66	85	147
+6988	PF07160	DUF1395		Protein of unknown function (DUF1395)	Moxon SJ	anon	Pfam-B_16376 (release 10.0)	Family	This family consists of several hypothetical eukaryotic proteins of around 250 residues in length. The function of this family is unknown.	25.40	25.40	26.30	36.90	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.54	0.70	-4.87	6	100	2009-01-15 18:05:59	2003-09-03 14:57:27	7	3	84	10	70	109	0	220.70	30	87.04	CHANGED	+ls.l+Ell.hRshh.sPshcsTLSsIssslsulchLLpchcp.lpppcps.sptKcLhpsohcpppch.tlctpsPsphs.csp.ssppssspsLlpcst....t.........cEpu.sppP.+ps...+.h.aITs-EFcSlPsYM+GRLTL-plNthlschssalsuKs+IlupspKpLocssRElhpcaR-lEsKsst+..G+aFFlEsDIKshssLKLDpoFtshlssLRHlpRlpEsRsGsLT	.........................................................................................hpc.l.............ss.hps..Lptlspp...lhslpphLpphchplp.pc.p.t.sphKcLhpshppp...c.cl..pclppp.lP...spl.....P...................ts....ps.s..psh.h.p..t.st.ts.pt.....................hpsp.p.t...spcs.+....ct..c........lt......ph.a......ITs-EFsulPpYM+GRLT...h-plNssl.p.-l.Nps.lhuKY+ILppP.+...K..s..hs.ss.s+p.......hhpca.h.-p.E..s..K-op...G.paFhlEsDI+ch.s......slK.lD.+p..h+.slLslLRHhpRlpElRsu...................	0	18	30	50
+6989	PF07161	DUF1396		Protein of unknown function (DUF1396)	Moxon SJ	anon	Pfam-B_16343 (release 10.0)	Family	This family consists of several putative lipoproteins from Mycobacterium species. The function of this family is unknown.	24.00	24.00	24.00	24.00	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.03	0.71	-4.64	17	288	2009-01-15 18:05:59	2003-09-03 14:59:51	8	1	134	7	53	132	1	191.50	36	78.19	CHANGED	Dsstl..lpcuspsT+slpSsHlsloVsGp.....lssL.slpol-GDlTssPtss..ApGssplhht..uttl.sscFllsDuslYssls..ssasshGsu..tslYDsuhl..LsP-pGlusVLu.shssspspGcEslsGpsTs+l....oGslsAssVstIsPs..hsus.tslPsTlWIs--..................sstpLspstl.chssGss....VplTlScWscsVsV	...................................................................................................-At.L..lcpuscAT+slpSs..HlslsVsGc..............lssL.....slpo...l..-uDlo.s..sPt.s...ApGssplhht......sssh...sscFlVh.s.splYsc...Ls........ss........aosh..Gsu........tsl...Yssuhl......LDPs.pG...........L.........uslLu.slp.ssps.pG..p-sID.Gl...sT.s.+l...............oGsls.Ass............lst..ls...Ps...............hsp......s...t.lPsTVWIsps..................Gs.pp.LVphpl...-hspGs...........VplThScWGc.Vsl..............................................	0	18	43	50
+6990	PF07162	B9-C2	B9;	Ciliary basal body-associated, B9 protein	Vella Briffa B, Coggill P	anon	Pfam-B_12595 (release 10.0)	Family	The B9-C2 domain is found in proteins associated with the ciliary basal body. B9 domains were identified as a specific family of C2 domains [1].  There are three sub-families represented by this family, notably, Mks1-Xbx7, Stumpy-Tza1 and Tza2 groups of proteins. Mutations in human Mks1 result in the developmental disorder Mechler-Gruber syndrome [2]; mutations in mouse Stumpy lead to perinatal hydrocephalus and severe polycystic kidney disease [3]. All the three distinct types of B9-C2 proteins cooperatively localise to the basal body or centrosome of cilia.    	20.80	20.80	20.90	21.10	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.95	0.71	-4.47	45	444	2012-10-10 12:23:49	2003-09-03 15:04:25	6	10	128	0	283	416	10	153.90	27	49.58	CHANGED	clhlhGpI.uAp...sapps.sL..............as+atlhtGs.sWp...........hlsGhp...................pGtTQhshsss...schsh...............asaPh-lphpsps.pG..................................WP....pLhlplau................hDshG+.ppltGYGhstl......Php.sG.pHplplshW+.P.......hsohhppLpphhlGusPpLpc..shlts..........spsRhtl+oco.sGpVplplsllh	.............................................................lhl.Gpl.sAp...thp..s..sL..............as+atl.hGt.....s.......Wp............hsG.p.....................pGhoQhsps....pt......s.phsh...................asaPl-lphtsps..G..................................WP......plhhpVhu.....................D..a.sp.phltGYGhshl......P.......h.......s..PG......p..........Hph........ph...s......hapP..............................ss..h..hpphtp.....hhhGttsphtc..phltt....................t.sR.h.hp.sts..tG..lphphphh.h.......................................................................	0	122	153	228
+6991	PF07163	Pex26		Pex26 protein	Moxon SJ	anon	Pfam-B_16379 (release 10.0)	Family	This family consists of Pex26 and related mammalian proteins. Pex26 is a type II peroxisomal membrane protein which recruits Pex6-Pex1 complexes to peroxisomes [1]. Mutations in Pex26 can lead to human disorders [2].	25.00	25.00	41.60	29.00	22.30	20.50	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.93	0.70	-5.52	3	66	2009-09-11 08:51:28	2003-09-03 15:14:33	7	2	40	0	27	66	0	266.40	54	93.40	CHANGED	MKSDSSTSAAPLRGLuGPLRSSEPsLAlPAsuPAVcLLEEAuDLLVVHLDFHAALETCERAWQSLssaA.AEEP.uGTplEVKCSLCVVGIQALAEMDRWREVLSWVLQYYQVPEKLPPKVLELCILLYSKMpEPGAVLDVVuAWLQDPuNQulP-YGoLAELHVhRlLLPhG+LSEAEELl...VGSAAFoEEQRl-ALQAIHsARQQpspppoQEHSsSp.......EsQKlspEGSlSpKLLSLlMLLRRLWuSAVSHlhSlPFRKuLLAALILCLLIlRFDPAuPSSLPFLY+LsQLFpph.pAshGRLYhLAsRS	...................................M+SDsSsSuAsh+GhsGsLRSSEPstssPshusAV...sLLEEAADLLVVHLDF+AAL-TCERuhpSLss.s.sEEs.suoslEVKCSLCVVGIQALAEMsRWpEVLSWVLQYYQVPEKLPPKVLELCILLYSKhpEPuAhL-VsuuWLpDPuNQsLPE.YsuLAEhHl.+VLLPLGploEAEELl...VGSsAFsEEpRhssLpslcpuRQQ......ppppcs..uo-.............Espc.sp-...G...uhspK.h..Lul.hLlpphhssuso...+hhShPF++uhLAALlLsLLllRhDP.AuPSSlsal.+Lh...pLhp.h.tuh.u.h..............................................	0	4	6	13
+6993	PF07165	DUF1397		Protein of unknown function (DUF1397)	Moxon SJ	anon	Pfam-B_16395 (release 10.0)	Family	This family consists of several insect specific proteins. Swiss:Q25513 is annotated as being a haemolymph glycoprotein precursor. The function of this family is unknown [1].	24.90	24.90	24.90	27.40	22.10	24.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.74	0.70	-5.14	17	111	2009-01-15 18:05:59	2003-09-03 15:42:10	6	3	35	0	77	116	0	191.90	28	72.67	CHANGED	-l..p.s..php..-lpchlcspCpcss.....GsDp...happlEpusps.hscClpGllDhsslppEIccApPsG-LDpVFsKYCt+tspuhpClsshpstlpPCL-p--ppphsshhshhppLLsFlCaK-GDpIALFIAEpGPEChpppp-sltpChspshsua.......sshp.up.hshsc..hu.pQCs-hsphpsChlccLEpCpssTPuNlsEShF+alR+toPC	........................................t..phtphpphhppcC.css........usst....hhpplppuhhp.hspClpshhs..hsthptEhpp.spPpGs.LDsVFpK.........YC..+hs.p.uhpClpsFsstlpsCLsp.-Eppt...s..hhhplhpplLsFlCh+sGDpIAl..FlucpGsEC.....hppp.pcslt.pChs..pshsth................psh.phs..p........thsp......hs.cpCs-ltphcsCllpc.LE.p.Css.s.suNlh-uhFchltptosC..................	0	23	31	67
+6994	PF07166	DUF1398		Protein of unknown function (DUF1398)	Moxon SJ	anon	Pfam-B_16404 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Escherichia coli and Salmonella species. The function of this family is unknown.	20.80	20.80	21.00	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.59	0.71	-4.23	6	734	2009-01-15 18:05:59	2003-09-03 15:46:05	6	1	607	1	25	177	1	121.40	41	91.93	CHANGED	QlllFpchF-pVRpDhNaphFYSELKRHNVSHYIYYLAT-Nl+IVhcNDssVLlKGt+pllpV+ho+NppLIcsost+ahStEloFpcYpcsLAsAGVFRWITslcEpKRaYYohDNoLLapEsl	...........................................hhhpchF-pVRp-.NFshFa...p-LKcpsluaYIYalATsNl+Ilpcs-sslll+us+s..llpVssopNpshIcpshttHhsGcpoFcpYCssLApAGVF+WlsDlppppRpYa.shDNpLLahEsl...........	0	11	15	22
+6995	PF07167	PhaC_N		Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	Moxon SJ	anon	Pfam-B_16456 (release 10.0)	Family	This family represents the N-terminal region of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulfur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond [1].  This family appears to be a partial segment of an alpha/beta hydrolase domain.	20.50	17.00	20.50	19.00	20.40	16.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-10.98	0.71	-4.83	37	1217	2012-10-03 11:45:05	2003-09-03 16:00:08	8	8	704	0	326	1286	296	145.90	45	28.33	CHANGED	.pD+RFusssWppNPhachltQsYLlsu+hlpphl-ps-..lDscs+pRscFhscQhssAhuPSNFlhoNPpsl+cslposGpSLlcGhppLhcDltputu..plppoDpsuFpVG+NlAsTsGpVVacN-LhpLIQYcPtTEpVac+PLLlVPPhINKaYILDLpPpNShlcas	.......................................tD+RFts.sWptpPhaphhhptYLh.tchhtphhpshp...ls.ppcp+htFhhpph.hsAhuPo.NhhhhNPt.hhcphhpotGpsLhpGhtphhpD...l...tps.t......h.p..ss.t.psFpl..G...c.....sl..A...s...TsG.pVVacNclhpLIQYp.P...h..T.......c....p....V..h.t.p..PlLIVPPhINKaYILDLpPcNShl+ah...................	1	81	187	258
+6996	PF07168	Ureide_permease	FAE_3-kCoA_syn1; Ureide_perm;	Ureide permease	Vella Briffa B	anon	Pfam-B_11634 (release 10.0)	Family	Heterocyclic nitrogen compounds may serve as nitrogen sources or nitrogen transport compounds in plants that are not able to fix nitrogen. This family represents ureide permease, a transporter of a wide spectrum of oxo derivatives of heterocyclic nitrogen compounds, including allantoin, uric acid and xanthine; it has 10 putative transmembrane domains with a large cytosolic central domain containing a 'Walker A' motif. Ureide permease is likely to transport other purine degradation products when nitrogen sources are low. Transport is dependent on glucose and a proton gradient [1].  The family is found in bacteria, plants and yeast.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.11	0.70	-5.76	4	165	2012-10-02 19:55:49	2003-09-03 16:15:55	6	4	88	0	57	194	24	229.70	39	66.75	CHANGED	MlLuLhFLGTWPAlLTLLERRGRLPQHTYLDYolTNLLAAllIAhohGEIGtspPscPsFhTQLsQDNWPSVLFAMAGGllLSlGNLuoQYAaAFVGLSVTEVITASITVVIGTTlNYFLDs+IN+AEILFPGVuCFLIAVFLGSAVHuSNAuDsKpKL......pshps.pp.tolpshEhcsh.....ppp-LEpGc..s-pscsGTAsFllELEc+RAIKVFGKSphIGLslThhAGlCFSLFSPAFNLATNDQW+TLc+GVP+LsVYTAFFYFSISsFllulILNlpFLY+PllGLP+SSlKAYlsD.sGRtWAlLAGhLCGFGNGLQFMGGQAAGYAAADAVQ	.............................................................hlohlhhGoWsshhpLhp++tRh.ph.hYhDYols.lLsullhAhThGphG....ps.sFhspL..s..Q..sshsSlhhAhhGGllhsluNlhhphAhAhsGhSVs.slu..sulslVl.GsslNYhh...s.sph..scs....lLFsGVushllAl.hl.s..uh.sat.............................................................................................................................................................................................................................................................................................................................................................................	0	18	39	47
+6999	PF07171	MlrC_C		MlrC C-terminus	Vella Briffa B	anon	Pfam-B_6316 (release 10.0)	Family	This family represents the C-terminus (approximately 200 residues) of the product of a bacterial gene cluster that is involved in the degradation of the cyanobacterial toxin microcystin LR. Many members of this family are hypothetical proteins.	25.00	25.00	30.90	30.80	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.84	0.71	-4.71	15	567	2009-01-15 18:05:59	2003-09-03 17:08:38	7	6	358	1	215	590	412	175.50	31	35.98	CHANGED	llADstDNPGGGusGDsTtlLcullc.Rshpss......ulusIa.DP.AVptstAAGtGAslsL+lGGKhustuupPlcscspVp+Lscsshps....htss.hslGssAsl+lt..G..lclIlsosRsQsa-.shFpslGl-PtspclLVVKSusHF+AsFtPlAppllhstuPuuhssDsspLsa++l	........lluDstDNPGuGusuDsThlLctLl.c...p.s..h..pss...............shuslh.DP.t...Asp..tshsA....G...h..........GApl.slplGu...+.....s....s....s....h....s....u....t...Pl..c.spspVtt..lscsthhs.........hts..t.h.p.hGssA.slcls......G.....lc....lllsop+p.phh-.shFpthGl.-Ppp.tc..llVlKSs.aa+u......sFts..lA..s....t.ll.hstuP..Gshs.p.Dhsplsap+.................	0	35	109	166
+7000	PF07172	GRP		Glycine rich protein family	Bateman A	anon	Pfam-B_15819 (release 10.0)	Family	This family of proteins includes several glycine rich proteins as well as two nodulins 16 and 24.  The family also contains proteins that are induced in response to various stresses.	30.00	30.00	30.50	30.20	29.80	29.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-11.19	0.72	-3.51	15	154	2009-09-11 20:33:22	2003-09-04 11:05:36	6	3	52	0	60	154	0	95.50	33	73.37	CHANGED	MA.SKA.hlLLGLhhsssLLluSEVuAtp.......usp.KsEscssVpssph.....................ttGGYsGGGGsthsGGGh.sGGGsass........................GttGh.tt....GGGYpGGG	...........Mu.SKs..hlLLuL.hhAslLLluS-VuAtc..........ttt..ps.p.sp..ss.....Vpssphhu..t.t....................ttGG.....as..GuG..Gt...t..........G.....G...G.....h.........ss.s.G..u.asG..............u.G..tGh..st.......G...tGh....t.................................................	0	12	34	47
+7001	PF07173	DUF1399		Protein of unknown function (DUF1399)	Vella Briffa B	anon	Pfam-B_13062 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within a number of hypothetical plant proteins of unknown function.	21.20	21.20	21.20	21.20	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.83	0.71	-3.88	16	332	2009-01-15 18:05:59	2003-09-04 13:51:26	7	9	120	0	256	357	6	114.40	26	21.11	CHANGED	pYpp.Ccphas+l.l...sptultsphppp.uh.pscclWpphaPpEsachphsstos.......tsstplspDLlusVhRQppFst+hs.......oPahp-s.aLppAhtRYptFlpllpp.tspc...hhLVPThDIDLhWHTHQLashsYhsD	.........................................................................................................................................................................hshDLssulhRQtt.F.htphs..................................pshht.p..s..lpcultRYp.t......F.ltlhpp....psp............thlVPTLDlDLhWHTHQL.sP.htYhp....................	1	86	161	234
+7002	PF07174	FAP		Fibronectin-attachment protein (FAP)	Vella Briffa B	anon	Pfam-B_16585 (release 10.0)	Family	This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix [1].	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.20	0.70	-5.12	8	90	2009-01-15 18:05:59	2003-09-04 14:53:17	6	4	83	0	15	77	0	271.90	62	85.80	CHANGED	McQsDspupRR+GL.soLAlAAVoGAoA....sulALPAsAsADPs.PsPs........sPPususAsPAPssP..sPuPsssPs................PuDPNAssP........P..ssADPNAPsPPPsDPNAPsP........ssPpsGRlDNAsGGFSYVVPAGWh.SDAopLsYGpALLSKhssEss.PspsPP..NDTpVlLGRLD.KLaAuAEsDNsKAAsRLuSDMGEFFMPaPGTRlNQpTlPLc.ANGhsGsASYYEVKFoDsNKPNGQIWsGVVGsPsAsusscG..sPpRWFVVWLGTANNPVDKuAAhsLApSIRPWsPPP.PPPsssPus	...................................McQVDss.TRRKGhhAsLAIA.AhuuASh....VTlAl...P.A.T.A.sADPE....PsPs.............ssPPS.TAsAP.......P.A.P.As.PsAPP.sPuAss.sPt............spPuDPNAAPP..........P.....AD.PNAPPP.PslsPNAPt.P..............sRIDNsVGGF.SFsLPAGWV...ESD.AuHLDY....GSALLSKsTG-PPhPsQPPPVANDTRIVLGRLDQKLYASAEAssoKAAsRLGSDMGEFaMPYPGTRINQETlsLD.ANGsoGSASYYEV...KFSDsSKPNGQ.IWTGVIGSPsAsussuG.....sPQRWFVVWLGTANNPVDKGAAKALAESIRPhssPP.PsPAPAPut..................................................	0	2	8	12
+7003	PF07175	Osteoregulin		Osteoregulin	Vella Briffa B	anon	Pfam-B_16589 (release 10.0)	Family	This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition [1].	22.10	22.10	22.60	38.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.87	0.71	-4.42	3	78	2009-01-15 18:05:59	2003-09-04 16:19:44	6	1	41	0	14	72	0	174.70	55	34.65	CHANGED	csNED+SSu..................GNQ-NIHpsLtASVYP-PTVsKGTEDGcDAlLHLhDQ-RYGAALLRNITQPVKSLVTGsELpuEcNKEK+PQSVLSVIPADVNsAKsaSKDpKNQQRDLLsQsSPVKS...KHT+RsRRSTHYLTHLPQIKKIPSDFEGSGSPDLLVRGDNDVPPFS	.........................................p..sEsptSs..................oNKENsHssL+MSIYPcSTGN+GsEDGDDAlSKLHDQEEYGAALIRNNMQH.lM.uPVTshc...L..LGEENKEsKPRNVLsKIP..Auh..NYAK.ApSKDK.Ks.QRDuQuQpsPVKS...KST...H+..hQHNhDYLKpLsKVKKIPSDFEGSG..YsDLQpRGDNDlSPFS.............	0	1	1	1
+7004	PF07176	DUF1400		Alpha/beta hydrolase of unknown function (DUF1400)	Vella Briffa B, Bateman A	anon	Pfam-B_16606 (release 10.0)	Family	This family contains a number of hypothetical proteins of unknown function that seem to be specific to cyanobacteria. Members of this family have an alpha/beta hydrolase fold.	23.00	23.00	23.20	24.10	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.45	0.71	-4.22	10	255	2012-10-03 11:45:05	2003-09-04 16:53:21	6	4	69	0	99	279	187	126.00	27	30.55	CHANGED	AAEplsLpYuPFpc.olsVp-LppFAcTGplsssL+hahphl..sspphppLRthLspRhplsPVtlupll....sSPlGcplLsplupllpssscpssthALRuAllpuAssPs.GlollsllpsYPopslcls	...............AAEplhlpa.us.hph..o...lsl.......psLcpaAc.s.......G.p....h.s......s...p..Lphahphh...stpp..hpplRphLppplpl..........ssshhsphL....po.hGctlLpp.l.upl...l...p...st.s...s.......p..s...uh....AlRu..All.pu.At............p..sp..slollshLcsaPspslpls............	0	6	65	95
+7005	PF07177	Neuralized		Neuralized	Vella Briffa B	anon	Pfam-B_16611 (release 10.0)	Family	This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system [1]. Some family members contain multiple copies of this region.	20.50	20.50	20.70	20.60	18.80	20.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.18	0.72	-4.10	6	930	2009-01-15 18:05:59	2003-09-04 17:04:25	7	17	92	2	581	865	1	68.60	35	23.45	CHANGED	PLp.FHs.s+GuNlplscstplA+R.cuSFCculsFSsRPltIsEpltl+lt+hppsWsGuLRlGhTspDP	............t.hp.FH..h+Gpplp.lss.ss.p....sAp....R......p...s..s.Fsp...G.lVaSsRPL+ssEhhpl+l..sch....s.s.p..Wu....G.ulclGlTshsP..................	1	163	205	374
+7006	PF07178	TraL		TraL protein	Moxon SJ	anon	Pfam-B_16378 (release 10.0)	Family	This family consists of several bacterial TraL proteins. TraL is a predicted peripheral membrane protein which is thought to be involved in bacterial sex pilus assembly [1]. The exact function of this family is unclear.	20.80	20.80	20.80	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.11	0.72	-3.97	22	417	2009-01-15 18:05:59	2003-09-05 09:50:48	6	2	336	0	58	226	12	91.80	35	93.44	CHANGED	cpYphPcpLscsp+lhhaslDEhls.hllhashGhhss+...hlhGlhlushhahul++hKtGcussalhchhYWaLPsshht..h+tsPsSphRhals	.........achPcpLssts+hhhhslDEllP.shlslshG.lho.u+.......hL..hGl..ss..ulllahsh++.hKcG+usuaLhchlYWahPsshht....h+slPsSphRpal....................................	1	15	31	46
+7007	PF07179	SseB		SseB protein N-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_16678 (release 10.0)	Domain	This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli [1] and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon [2]. This entry contains the presumed N-terminal domain of SseB.	19.90	19.90	20.30	20.40	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.52	0.71	-4.30	133	1525	2009-01-15 18:05:59	2003-09-05 10:51:25	7	20	1195	0	280	1063	109	116.10	25	48.96	CHANGED	Lcpslp...th..tps........ttstpthhptL.....hp.....uclhlPl.spsss.................................tt...tsphphh.hlp....tt-Gpp.....hlssFTohcplpphts.........pttsh.hshshpslhphh.......tps.tulllNPtss.t....thhlstptlttl	.................................................thLtts.tsc.......tpp.thhcsL........hc.....uplaVPsssstsp...................................p...ssslsl..phc.........pp-.Gps.....hlPhFToh-tLpphsp................cppsh..hsh...sscsLhphhh.......ts.p...slhLNstss.s........sh.h.sctlt............................	1	77	194	247
+7008	PF07180	DUF1401		Protein of unknown function (DUF1401)	Moxon SJ	anon	Pfam-B_16789 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 135 residues in length. Members of this family appear to be found exclusively in the Enterobacteria Escherichia coli, Citrobacter rodentium and Salmonella typhi. The function of this family is unknown.	25.00	25.00	25.00	26.40	24.10	24.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.96	0.71	-4.43	2	589	2009-01-15 18:05:59	2003-09-05 10:56:52	6	1	423	0	13	126	0	109.00	50	76.67	CHANGED	hsupsppsshhIPsSV+pYsGEPLYIlVuhWChLQppWlpRNpIAEAFtIshRRASalIsYlpp+pp+ls.hsRa.ohsN.+h+RhEIalhcV..pssP.pp..psGP....KR...RVGNG.hu.uN.lWNch........Ih++Kc-p	...............h.t..................Ys-+PLYLLIA-WMMAENRWVhAREIShpFDIEHsKAlNTLoYIL.S.E.V..sEIsCEVKM.....................................................................................................sp..uttspppphlhhVs.................................	0	1	4	10
+7009	PF07181	VirC2		VirC2 protein	Moxon SJ	anon	Pfam-B_16860 (release 10.0)	Family	This family consists of several VirC2 proteins which seem to be found exclusively in Agrobacterium species and Rhizobium etli. VirC2 is known to be involved in virulence in Agrobacterium species but its exact function is unclear [1,2].	25.00	25.00	57.70	57.50	19.60	15.20	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.28	0.71	-4.91	5	16	2009-01-15 18:05:59	2003-09-05 11:12:19	6	1	9	1	4	13	0	179.10	54	99.72	CHANGED	MGIRKPALSVuEARRLAAARPEIVHPsssluSQ-sAsspLPE+AG+EDRpssPssAKRpcSsDRQSMLTVDALSSosuPEKlQVFLSARPPAPEVSKIYDNLILQYSsSKSLQMILRRALuDFEsMLADGSFSsAPKSYPIPpss.EKsVIVQTSRMFPVSLLEVARNHFDPLGLETARAFGHKLATAALASFFAcEKso...+sp	MGIRKPALSVuEAR.RLAuARPE...Il+Ps.slso.psssssphPEcucpc-RpstPssAcRptssDpQshL.....TVDALSossuPEKlQVFLSARPPAPtVSchYDsLlhQYSsSKSLQMILRRALsDFEsMLtDGSFptAspSYPIsp.s.pK.llVQTSRMFPVsLlElARsHFDPLGLETuRAFG+KLATAALASFFstEKss...t...	0	1	3	3
+7010	PF07182	DUF1402		Protein of unknown function (DUF1402)	Moxon SJ	anon	Pfam-B_16561 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 310 residues in length. Members of this family seem to be found exclusively in Agrobacterium, Rhizobium and Brucella species. The function of this family is unknown.	20.10	20.10	21.00	24.80	17.80	17.50	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.80	0.70	-5.54	9	105	2009-01-15 18:05:59	2003-09-05 11:14:38	6	2	93	0	23	69	1	300.30	69	93.33	CHANGED	shhsssssApAhplVPsGNRsAEQPsIPGASuRRT+AspToa-tKYcKVhsLLpsD+sLhuKI+psAuAYGIDPIHIVGAIVGEHTYNVDAYDRLQoYYVKAhSYuupsFpFuYcGEslspFlpRPpFupCtt...hp-SYsLWSCREsVWsssFRGKoVsGpuaPssRFuAsFFQPFYAGQTFGLGQlNPLTALploDhVsRlSGa.KLstscspuVY+sIMDPDlSLsYlAAhIRcSIDAY+pIAshDIStNPGlTATLYNVGsPcpRAssLtspNp....uGtt.hLPpENYYGWLVNDKL-EL+uLL	......uh.hluSpuAcAlTVVPPGNRNAEQPsIPGASA+RT+thSTTYE+KY.QKIYsLL++DuSLRuKIRSTAAAYGIDPIHIIGAIVGEHTYNVDsYDRLQTYYVKAhSYlspulSFGYsGESIuQFlcRPEFAsCh+...hKDSYSLWoCREsVWNu-FRGKoVGGKAYPNNRFSAVFFQPFYAGQTFGLGQINPLTALQMSDMV.NRlSGLPKLDADDuNAVYKTIMDPDLTLPYIAAoL+pSIssYRpIADFDISKNPGITATLYNsGGopARAcsLAsENu+R+AAGpEPhLPpENYYGWLVNsKLDELKALF..	1	3	10	14
+7011	PF07183	DUF1403		Protein of unknown function (DUF1403)	Moxon SJ	anon	Pfam-B_16581 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 320 residues in length. Members of this family are mainly found in Rhizobium and Agrobacterium species. The function of this family is unknown.	21.80	21.80	21.80	24.40	20.00	21.40	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.88	0.70	-5.05	19	66	2009-09-10 21:27:44	2003-09-05 11:24:43	6	2	36	0	25	69	7	256.30	41	97.24	CHANGED	phs...ssusss.sh.PplPuWltstss-............s.p-sAFtuGAALssLDsllR..ppssWtGsWRpRLALcuAssss+htGRsE-EsuLRDAlhLppsGD..cPGPAGclahAWRcLsppsss...s...lhtlsshLG.....culuslsspltsh....hpuspsuPl.suAtlhuslhshtPpAElluhhLADslLAppLsWs+slPLLusph......t.shRsh.sstsclR.scsshtpAlphAlssuAspAlR.AsElsRRAs+LhAVAPKLRuKGAssslchlLs-DAlsu..........S.....shstLSchAARRLF-RLhsLGAVRELSGRsoFRlYGL	..........s.............s.hPuWshstttp..............s.pDsAFhuGuALssLc.llp.....tp.s.tuhhRpRLALpuAtsssth.GRsEctssLRDAhhLhtsGD...sGPAGphhhuaRphstpsss...........ht.ls......culsslssth.th....hpsttsssh.tuA.hhtthht...s...pu.........-hhuhhLADhsLAptLsWs+.VPLLusth..................ttsclp.tttsh.hAsphAlhpushpAlc.us-lsRRAt+LhAVAPKLRuKGAstslphhLscDAlss.........u.....shs.hschAARRLh-RLhpLGAVRELoGRsoFRlYGl..............	0	1	16	22
+7012	PF07184	CTV_P33		Citrus tristeza virus P33 protein	Moxon SJ	anon	Pfam-B_16614 (release 10.0)	Family	This family consists of several Citrus tristeza virus (CTV) P33 proteins. The function of P33 is unclear although it is known that the protein is not needed for virion formation [1].	25.00	25.00	247.30	247.20	17.40	16.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.00	0.70	-5.59	2	230	2009-09-10 15:37:21	2003-09-05 11:29:21	6	1	1	0	0	186	0	201.30	88	100.00	CHANGED	MFAFASENQDlLEEKIFRRRThHRKYhDDVVRDFTIDlGYDhVDRDPTVLADYhSLYFFLLNND.lGPLAASIhVSPPVsGTHKIRAHlDNQPNpEGNVTYlKTVDKSRFsIhIKAhPAsMRGaYShRAFLuuDVsStpsEFICSFVGSRFLCCsTQTISENLsKVCSSSF.FRsVScTAhNEFSVshDDVEDVKYVRKRAEGF.HCADPYPPRCYRssNLGDsSGVQSRTIEEEGYRTDTsGNVAVolPNTPLVNAVSPYVAEYNENsRSRISLIRRVCCYAVCVLVVSLLIMSGLLsIIhI	MFAFASENQDlLEEKIFRRRThHRKYhDDVV+DFTIDlGYDssDRDPTVLADYFSLYFFLLNNDNlGPLAASIlVSPPVsGTaKIRAHVDNQPNpEGNVTYVKTlDKSRFsI+IKAlPAsMRGYYSFRAFLouDVASERSEFICSFVGSRFLCCCTQTISENLuKVCSSSFFFRAVSETATNEFSVsTDDVEDVK................................................................................................................	0	0	0	0
+7013	PF07185	DUF1404		Protein of unknown function (DUF1404)	Moxon SJ	anon	Pfam-B_16616 (release 10.0)	Family	This family consists of several archaeal proteins of around 180 residues in length. Members of this family seem to be found exclusively in Sulfolobus tokodaii and Sulfolobus solfataricus. The function of this family is unknown.	27.00	27.00	27.50	27.50	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.02	0.71	-4.68	14	66	2009-01-15 18:05:59	2003-09-05 11:40:19	6	1	19	0	23	53	0	153.20	32	84.69	CHANGED	hhslhLllhslNPaoEph.hhsshlaMhuHYuLahuGhLlGhhhh+t.....shhh..hl..............lGhhhslhWHlPhaFsluus.h.hRllp-loLllGGlLhGuShpthshhhK.lsLhuLWMhuDohLuIlhllusshYosh.h.aSPYssppLshsGlhMFlhMsllhsallh+h.l.Ksl	...........................................hhhhhh.lNPhs..h.....h.hMhsHY.lhhuGhhluhhhh+t...............s.l...hh................lGhh.shhWHhPhhFslusthhhhRllpclohhlGGlllGSulptlphshK.lhLhuLWMhGDolLullLhlusshYos....h.sYsspph.hsuhhMFlhMslhhhhllhch.hpt.....................................	0	3	4	18
+7015	PF07187	DUF1405		Protein of unknown function (DUF1405)	Moxon SJ	anon	Pfam-B_16845 (release 10.0)	Family	This family consists of several bacterial and related archaeal protein of around 180 residues in length. The function of this family is unknown.	25.00	25.00	41.90	41.90	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.09	0.71	-4.52	31	478	2009-01-15 18:05:59	2003-09-05 13:01:54	6	1	459	0	77	287	1	164.10	48	83.05	CHANGED	TlaG.ahWY............t....QLspTPhhha.FVPDSPsAoLFhslsLluhL...............hs+sh.....shlcALAhVsLlKYGlWslshplhhhht..s..sshshhthhLllSHhuMulpuhLah.ah.+hphhtlslAslWhhhNDslDYhhh..hPhhsh.ht.a.hspluhhs.............hhlulhslhlshaLshp	....hIYG.YIWY............u...pQL....scT....P....h.....hFhlFVPDSPTAhLFhllulhhhL...............hpKp..........ulI-ALAaVTLhKYGlWAVlMNllhhhp......pGsIs.hpGhhLhhSHshMAVQAlhahPha..+hshhtlsVAhlWshhNDhIDYhahQ.hPhYsh...lppa..lhpIG..hho..................hhLSl.huLhlhh.hs.+..........................................	0	20	52	69
+7016	PF07188	KSHV_K8		Kaposi's sarcoma-associated herpesvirus (KSHV) K8 protein	Moxon SJ	anon	Pfam-B_16868 (release 10.0)	Family	This family consists of Kaposi's sarcoma-associated herpesvirus (KSHV) K8 proteins. KSHV is a human Gammaherpesvirus related to Epstein-Barr virus (EBV) and herpesvirus saimiri. KSHV open reading frame K8 encodes a basic region-leucine zipper protein of 237 aa that homodimerises. K8 interacts and co-localises with human Pfam:PF04855, a cellular chromatin-remodelling factor, both in vivo and in vitro. K8 is thought to function as a transcriptional activator under specific conditions and its transactivation activity requires its interaction with the cellular chromatin remodelling factor hSNF5 [1]. 	25.00	25.00	440.70	60.80	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.69	0.70	-5.13	2	10	2009-01-15 18:05:59	2003-09-05 13:08:26	6	2	3	0	0	9	0	181.40	89	86.96	CHANGED	MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVK.................................................AEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ	.MPRMKDIPTKSSPGTDNSEKDEAVIEEDLSLNGQPFFTDNTDGGENEVSWTSSLLSTYVGCQPPAIPVCETVIDLTAPSQSGAPGDEHLPCSLNAETKFHIPDPSWTLSHTPPRGPHISQQLPTRRSKRRLHRKFEEERLCTKAKQGAGRPVPASVVKVGNITPHYGEELTRGDAVPAAPITPP.PRVQRPAQPTHVLFSPVFVSLKAEVCDQSHSPTRKQGRYGRVSSKAYTRQLQQ.	0	0	0	0
+7017	PF07189	SF3b10		Splicing factor 3B subunit 10 (SF3b10)	Moxon SJ	anon	Pfam-B_16870 (release 10.0)	Family	This family consists of several eukaryotic splicing factor 3B subunit 10 (SF3b10) proteins. SF3b10 is a 10 kDa subunit of the splicing factor SF3b. SF3b associates with the splicing factor SF3a and a 12S RNA unit to form the  U2 small nuclear ribonucleoproteins complex. SF3b10 and SF3b14b are also thought to facilitate the interaction of U2 with the branch site [1].	18.50	18.50	20.10	20.70	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.50	0.72	-4.15	19	296	2009-01-15 18:05:59	2003-09-05 13:40:43	6	5	270	0	214	245	2	77.40	49	82.45	CHANGED	D+hphpsQLEpLQu+YlGoGHsDTT+.aEWhsNlpRDohuSalGH.shLsYhulu.cNEshu+lRhphL.........................p+MltPssss...Pt	.......D+hphpsQLE+LQuKYlGTGHAD.TTK.aEWhsN.+RDoauSahGH.slLsYhAlA...EN..E.u.huR.l.Raphh.........................cKMlpPsGsPP...............	0	75	116	176
+7018	PF07190	DUF1406		Protein of unknown function (DUF1406)	Moxon SJ	anon	Pfam-B_16883 (release 10.0)	Family	This family consists of several Orthopoxvirus proteins of around 185 resides in length. Members of this family seem to be exclusive to Vaccinia, Camelpox and Cowpox viruses. Some family members are annotated as being C8 proteins but their function is unknown.	20.20	20.20	20.40	20.50	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.40	0.71	-4.55	4	194	2009-01-15 18:05:59	2003-09-05 13:49:14	6	3	31	3	0	180	0	168.20	33	67.41	CHANGED	M.sI+hIshLhlIhs...lushp.ss.YpP............FNKLsIsL-IYsh-sl.ssYTssN......hl.hpchhIol.op.Csshhso.-l.sspDhp.lthhhhDp.phQpps+hCplshchpCph.pcP..lt..p....phShpu-.....hpChpslch.Ishlp....DpphL+.paTL+Iss...............thsl	......................................................P............FNhlsVclslYsV.N..sShTps.s.......sps.s.sIsTpEhTITl.pcs..CsPsFcs..sh.aolhsplshsuaFps-.sc.hQspsKhCTlshcl+Csp....psp.....s......lpphpt...c...spphs.puE.....GcCLsulcl.I.Y.N...Tssp.hc.p.p.l.........t.hhst.h...........	2	0	0	0
+7019	PF07191	zinc-ribbons_6	DUF1407;	zinc-ribbons	Moxon SJ	anon	Pfam-B_16889 (release 10.0)	Family	This family consists of several short, hypothetical bacterial proteins of around 70 residues in length. Members of this family have 8 highly conserved cysteine residues, which form two zinc ribbon domains.	25.00	25.00	25.00	25.00	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.94	0.72	-4.19	20	619	2012-10-03 10:42:43	2003-09-05 13:53:40	7	1	612	2	48	200	3	69.30	60	95.42	CHANGED	-hhCPsCpppL-hsu...tphHCspCppcaphpAhCP-CpppLEcLpACGAssYFCp.pCNpLhSKpRVcFphp	.............ElpCPpCpps.L-pss............spA+CsoCsc.....s.....hphpAlCPDC+QPLQVLKACGAVDYFCQ..pGHGLISKKRVcFVl.u....	0	8	17	32
+7020	PF07192	SNURF		SNURF/RPN4 protein	Moxon SJ	anon	Pfam-B_16890 (release 10.0)	Family	This family consists of several mammalian SNRPN upstream reading frame (SNURF) proteins. SNURF or RPF4 is a RING-finger protein and a coregulator of androgen receptor-dependent transcription. It has been suggested that  SNURF is involved in the regulation of processes required for late steps of spermatid maturation [1,2].	25.00	25.00	74.40	74.10	23.10	16.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.37	0.72	-4.12	2	30	2009-01-15 18:05:59	2003-09-05 14:02:14	6	1	21	0	11	31	0	67.40	87	89.83	CHANGED	MERuRDRLHLRRTTEQHVPElEVQVKRRRTASLsNQECHlY.RRSQQQQlPVVDFQAELhQAFLAETPRGG	.........RDRLHLRRTTEQHVPEVEVQVKRRRTASLSNQECQLYPRRSQQ..QQVPVVDFQAELRQAFLAETPRGG	0	2	2	2
+7021	PF07193	DUF1408		Protein of unknown function (DUF1408)	Moxon SJ	anon	Pfam-B_16879 (release 10.0)	Family	This family consists of several hypothetical Lactococcus lactis and related phage proteins of around 75 residues in length. The function of this family is unknown.	21.50	21.50	21.90	144.50	19.70	20.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.57	0.72	-4.45	2	18	2009-01-15 18:05:59	2003-09-05 15:35:39	6	1	18	0	1	7	1	73.90	76	97.15	CHANGED	McTpIhNGRcVhhlPTslG.haaDL.KREshG.Vl.pTacR.DGohYhhpRp+scpE....KAAMLNpClSDWth	METTIINGRKVRllPTsVGQIYHDLIKRENRGVVVFETWcRPDGSLYMTSRKKNKQELAADKAAMLNECISDWKK	0	1	1	1
+7022	PF07194	P2		P2 response regulator binding domain	Finn RD	anon	Pfam-B_7970 (release 10.0)	Family	The response regulators for CheA bind to the P2 domain, which is found between Pfam:PF01627 and Pfam:PF02895 as either one or two copies.  Highly flexible linkers connect P2 to the  rest of CheA and impart remarkable mobility to the P2 domain. This feature is thought to enhance the inter CheA dimer phosphotransfer  reactions within the signalling complex, thereby amplifying the phosphorylation signal [1].	21.30	21.30	22.00	21.50	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.50	0.72	-4.13	80	704	2009-01-15 18:05:59	2003-09-08 09:47:26	6	18	549	1	219	650	12	84.00	26	13.32	CHANGED	psYplcVplscsshlKusRAahlhcsLc-hG.-llcohPshE-l.Es-p....F..cpphplhlloppst-clcphlt.sluEl......cpVplpphp	.......................haclplplpc.sshhKulRAhhlhcsLcc..hG.cll+ohP...s..hEcl..Es-p........F..tppFplhhho.p.p..s..t..-clcphl...pluEl......ccVplpp..s........................	0	88	155	181
+7023	PF07195	FliD_C		Flagellar hook-associated protein 2 C-terminus	Yeats C	anon	Yeats C	Family	The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria [2]. This alignment covers the C-terminal region of this family of proteins.	25.40	25.40	25.40	25.50	24.80	25.20	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.66	0.70	-5.07	35	2213	2009-09-13 17:36:45	2003-09-08 11:04:28	7	11	1857	0	507	1693	494	236.90	25	45.96	CHANGED	ApsAplslsG....h.slpssoN.plssslsGVolsL................ppsopssp.......slsl.spDssshppslpsFVcuYNplhsplsshos.....................t.tt.pppspsGsLtGDusl+slpspL+shhts....t.sss...........hpsLsclGIosspt.p...........GpLpl...DcsKLcpslp..pssssltph.....................................................................FsG.........................................ssGlspp..............lpstlpshs.....pss.Ghlp...................scpssLscphpplspphpshsc+hcshpp+hppp..Fsth-phhsphss	................................................................................................................................................ApsApls..l.sG...............l..pl.pp.soN..plsss...l.pG.l.T.lsL............................pp.s....s.ttst...........slsl...spDs.s....s.sppslpsaVs.uYNsLlsshsshop................................................t..pps..tpsGsL.hG.D.u.s.lps.l...p.splcshlss..........s.t..sss..................hpoLsplG.Iohsps...............................GpLp.l.....................Ds..sKLpp..A..Lp..p..s..s.su.ltph...........................................................................................................................................................................................................................................................................................................................................Fs.u.....................................................................................................................................p.sGl.ssp.......................ltshlss..hh......................sss...Gh..lp.....................................stps...u...lspplpplscphpshspp.hcsh.s+..hptp.....Fsth-shhsphp...........................................................................................................	0	175	326	420
+7024	PF07196	Flagellin_IN		Flagellin hook IN motif	Yeats C	anon	Yeats C	Motif	The function of this region is not clear, but it is found in many flagellar hook proteins, including FliD homologues ([1]). It is normally repeated, but is also apparently seen as a singleton. A conserved IN is seen at the centre of the motif. The diversity of these motifs makes it likely that some members of the family are not identified.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.66	0.72	-3.98	132	2915	2009-09-13 07:46:12	2003-09-08 15:29:45	8	27	1152	5	475	2258	345	56.80	25	13.44	CHANGED	slslphssttt..........lshsss..sshss.lsstIN...........sspsGVpAoh.......ssp.......upLsl...puss	..................................lslptssttts................l.shpss..sslts.l....sstIN............ss..ss.G.V.pAol.............sps..........upL.lput.......................	0	140	264	375
+7025	PF07197	DUF1409		Protein of unknown function (DUF1409)	Vella Briffa B	anon	Pfam-B_16557 (release 10.0)	Family	This family represents a short conserved region (approximately 50 residues long), sometimes repeated, within a number of hypothetical Oryza sativa proteins of unknown function.	21.10	21.10	21.20	21.20	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.47	0.72	-3.90	51	427	2009-01-15 18:05:59	2003-09-09 17:00:33	7	14	7	0	308	422	0	46.30	47	12.38	CHANGED	RLEsppl-.L........AcLcEh...pApls.Eh......tclhs.sthlE...pp+....hK.Lcp	..........................RLEApplD.L..........ApLc.Es.............pApls.Eh.....................tclhs.sthlEppp....h+Lcp.............	0	1	1	7
+7026	PF07198	DUF1410		Protein of unknown function (DUF1410)	Vella Briffa B, Bateman A	anon	Pfam-B_13132 (release 10.0)	Domain	This family represents a conserved domain approximately 100 residues long, multiple copies of which are found within hypothetical Ureaplasma parvum proteins of unknown function, as well as related species.	21.00	15.50	21.10	15.50	20.90	15.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.27	0.72	-3.66	67	980	2009-01-15 18:05:59	2003-09-09 17:11:28	6	16	37	0	55	835	4	68.20	20	15.61	CHANGED	spphtstplpl........phpDpsppphpl.....................phphsppppslt.....hssLpss.....p..p..Yplsclshsspphphs	...................................................hhNpplph........hhpDps.sppapl...............................pspl.spssphhh.....h..hss...Lsss.....p.....pYplsclhhsspp...................................	0	51	55	55
+7027	PF07199	DUF1411		Protein of unknown function (DUF1411)	Vella Briffa B	anon	Pfam-B_16764 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long that is sometimes repeated within some Babesia bovis proteins of unknown function.	20.70	20.70	20.90	21.20	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.10	0.71	-4.86	6	33	2009-01-15 18:05:59	2003-09-09 17:23:38	6	3	15	0	12	26	0	151.80	31	67.59	CHANGED	MSGHLVCKSGFGLGKVAKLMLASVVVLSAFSsNVWA.....scAEsspcPh.tph-GGhhot...............h--hpKL..pshsDlspT-NTEKTsLuDlSVKLGPhc+sM..hlKcVDVDMphLN+RIollLp+lTsaGP-SPsFGlSENIVKsLNK+GoIElPKcLAQpLCphcoGKhppYEWppFpDtFuoalA-hlss	.......................................h..............................................sp.s..tphpshh.oh...............h.pss...--hpKh..p.h..lpp.sc.T...EKo.l.h.lh.lp.ts.hcpshphplp.sssVp.h.hspccLoolLt.tlsphsPto.hhulScNllchLsKpp.p...-h.pclAptLsplcothhth.E..................h...................	0	12	12	12
+7028	PF07200	Mod_r		Modifier of rudimentary (Mod(r)) protein	Vella Briffa B, Wood V, Mistry J	anon	Pfam-B_16631 (release 10.0)	Domain	This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic [1], and both of these regions are represented in this family.  Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB).  The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37).  The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors [2].	27.00	27.00	27.00	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.97	0.71	-4.29	17	469	2009-01-15 18:05:59	2003-09-10 11:27:18	8	9	245	5	303	465	1	139.30	27	52.13	CHANGED	lpphShs-LpcLlpDc-thpc.hhtphsp..lpslppp+-phhspscpLAccNLthpspLcph+splp.pchppLpplppphpphhpchcch.upphSspslhphLQhsspcs-E-oEph..sccFLcGchsl-sFlppahphRphhHhR+hp.EKL	..................................pthohppLpclhp.sp...ph...lpp.hh...p....hsp....lpp.h....ptp..p-thls.sNcpL..A...............c..pNL..th.p..spLpp.hR...splp.pphpplpplppphpppp.p.ch..cc........h..pshosps.Lhth..LpststctEc.....-o-sh......s-pF..L.-...........G........c........h....s........l..p.sF.....lppa.phRphhHhR+.p.-+......................................	0	82	131	214
+7029	PF07201	HrpJ		HrpJ-like domain	Vella Briffa B, Moxon SJ, Bashton M, Bateman A	anon	Pfam-B_16649 & Pfam-B_11026(release 10.0) & Pfam-B_1285(release 5.4)	Domain	This family represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered to plant cells [1].  This family also includes the InvE invasion protein from Salmonella.  This protein is involved in host parasite interactions and mutations in the InvE gene render Salmonella typhimurium non-invasive [2].  InvE S. typhimurium mutants fail to elicit a rapid Ca2+ increase in cultured cells, an important event in the infection procedure and internalisation of S. typhimurium into epithelial cells [2]. This family includes bacterial SepL and SsaL proteins. SepL plays an essential role in the infection process of enterohemorrhagic Escherichia coli and is thought to be responsible for the secretion of EspA, EspD, and EspB [3]. SsaL of Salmonella typhimurium is thought to be a component of the type III secretion system [4].	22.30	22.30	25.40	23.00	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.85	0.71	-4.23	36	767	2009-01-15 18:05:59	2003-09-10 11:43:52	6	4	513	10	60	405	7	160.10	23	46.32	CHANGED	s...........hhpphEctutsLspRch...........tptppppphpphhchl-ch.-tpt-p...phcpLpptLtt.....hssssplhshlpthhsDsucthlsL....pthlpp....ps.spthtptlppslppLpp..cputplpuGlNs...Ahtuttaut.tsstphptLRsLYppsl...tsp.tshsshhpslhppa	.......................................................tt.h.psh-chuhuLsphtt....................+tp.tcp.pphtpthp+llcpptps...........chcplhthh................tss.tph.s.hpthhs-suptllsL....pthLpp......cslpppl+cplpphLpcltt...pcshpl..Ghp......AlhutLhut...s......stshptLRphYcphl....psp.tshsphapclhsp..................	0	16	26	41
+7030	PF07202	Tcp10_C		T-complex protein 10 C-terminus	Vella Briffa B	anon	Pfam-B_13039 (release 10.0)	Family	This family represents the C-terminus (approximately 180 residues) of eukaryotic T-complex protein 10. The T-complex is involved in spermatogenesis in mice [1].	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.42	0.71	-4.73	8	224	2009-01-15 18:05:59	2003-09-10 11:56:30	8	9	126	0	134	206	9	150.70	39	21.12	CHANGED	KlEplhssGpRlIhFPNGT+KEISADGcoVpVpFFNGDIKcs.hs-tpVlYYYu-sQTTHTTYPDGLEVLpFPNsQpEK+asDGoKEIpFPDsTlKhLpscGp...EEslaPDGThlplp+sG-KhIpFsNGQ+EIHTspaKRREYPDGTVKTVYssGpQET+YosGRlRlKDc-GplIhDoc	..............................................................Ehh.htsGpp.lhasNGshKcl...t..s......Dt...ts.......shlpF.hNGDlKph..hs-...t.p.l..lYaYA..s.sp..ThHTTa..P.............-.Gl.EllpF.ss.sQ...........hE+..+aP.DG..p.....K.EIhFPDsol...K.l.scGp...E.EohaPDGTh.hphp.h..sGs.Khl..h.sN...G.p.c...El.+T.tt.hK.+............+ca.PDGThKhlas.s.GppEoph.sGph+hc...G............................................	0	63	74	99
+7031	PF07203	DUF1412		Protein of unknown function (DUF1412)	Moxon SJ	anon	Pfam-B_16907 (release 10.0)	Family	This family consists of several Caenorhabditis elegans proteins of around 70-75 residues in length. The function of this family is unknown.	25.00	25.00	25.80	34.00	20.80	16.00	hmmbuild  --amino -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.70	0.72	-4.05	7	36	2009-01-15 18:05:59	2003-09-10 12:39:10	6	1	5	0	36	28	0	51.90	69	68.96	CHANGED	GII.R-RR..psYassNGVVNNhVoDshhGGPTSLGWAQVPHlhSPMFSPVFG+	................GlI.RcRR..psYWhoNG.VV.NNhVSDNlsGGPTSLGWAQVPHhaSPMFSPVFGK..	0	9	17	36
+7032	PF07204	Orthoreo_P10		Orthoreovirus membrane fusion protein p10	Moxon SJ	anon	Pfam-B_16940 (release 10.0)	Family	This family consists of several Orthoreovirus membrane fusion protein p10 sequences.  p10 is thought to be a multifunctional protein that plays a key role in virus-host interaction [1]. 	21.20	21.20	21.30	21.30	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.43	0.72	-4.25	3	41	2009-01-15 18:05:59	2003-09-10 12:45:47	6	3	23	0	3	35	1	88.50	50	66.91	CHANGED	MhpMsSGSCNGATSVFGNVHCQAAQNTAGGDLQATSSlIAYWPYLAtGGGlIlIIII.luLlYCC+AKVKsDAsRSVF+RELlALoSGKsNAsPPuYD.V	..........................sGsCsGhsulFGsVHCQuupNoAGGDLQATSslhs.YWPYLAuG..G.GhlLIlIl.luLlYCC+uKhKscusRssa+RELVALopuphpshssshp.....................	0	1	1	3
+7033	PF07205	DUF1413		Domain of unknown function (DUF1413)	Moxon SJ, Bateman A	anon	Pfam-B_16942 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins which seem to be specific to firmicute species. Members of this family are typically around 100 residues in length. The function of this family is unknown.	25.00	25.00	25.10	26.30	23.70	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.09	0.72	-4.44	28	386	2009-11-04 10:27:19	2003-09-10 12:53:35	6	2	261	0	18	117	1	70.20	40	75.51	CHANGED	hccthptlcplsssssFph+..DLasc.......pWsphspsp+p.plG+hFhphVppsstht..h.hh.s+cssspphYpK	........h+ctlhtlps.sctosFsF+..DLFS+.......pWlshShA-RQ.cst+tFta.VKphscV...h.hs.ut.csu..thplYp............	0	8	13	18
+7034	PF07206	Baculo_LEF-10		Baculovirus late expression factor 10 (LEF-10)	Moxon SJ	anon	Pfam-B_16893 (release 10.0)	Family	This family consists of several Baculovirus specific late expression factor 10 (LEF-10) sequences. LEF-10 is thought to be a late expressed structural protein although its exact function is unknown [1].	19.70	19.70	28.70	62.20	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.35	0.72	-4.33	21	48	2009-01-15 18:05:59	2003-09-10 13:04:46	6	1	47	0	0	45	0	71.10	41	93.58	CHANGED	opsh.ts..DllssIL+cNLpLlDNsYlILNVlDpcss..p.......lcshClGEIsuhQs.cpssp.cuhSsoSsoSELpS	.....s..s..ts.sDllssILKcNLpLlsNsYIILNVlDpcss...p.........l+shClGEIsuhQT.csssp.-shSsSSsoSELpS...	0	0	0	0
+7035	PF07207	Lir1		Light regulated protein Lir1	Moxon SJ	anon	Pfam-B_16937 (release 10.0)	Family	This family consists of several plant specific light regulated Lir1 proteins.\	 Lir1 mRNA accumulates in the light, reaching maximum and minimum steady-state levels at the end of the light and dark period, respectively. Plants germinated in the dark have very low levels of lir1 mRNA, whereas plants germinated in continuous light express lir1 at an intermediate but constant level. It is thought that lir1 expression is controlled by light and a circadian clock.  The exact function of this family is unclear [1].	25.00	25.00	39.60	39.50	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.12	0.71	-3.96	5	52	2009-01-15 18:05:59	2003-09-10 13:11:41	6	1	31	0	16	46	0	122.90	41	93.23	CHANGED	MQsAuShslolsus.soosoupShshhhPpphps.pAsRpsphRl+Auuuuss.DsuTVDYsSsh.SVFPAEACDTlGGEACsu-MYPEVKLcs-ussss..sAsoEsVDREYLEY.s-PKTVFPAEACDDLGGEFC-P-	.........................................................s..p.....h.h............t.pthphts...u.s.sss-suTVDYs.Ssh.SVFPAEAC-slGGEACp.u.-MYPEsKLpspu.tsss......psssEsl-REYLpY.s-PKTVF.sEACDDLGG-FC-s.........	0	1	9	13
+7036	PF07208	DUF1414		Protein of unknown function (DUF1414)	Moxon SJ	anon	Pfam-B_16906 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.	25.00	25.00	48.30	47.80	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.81	0.72	-4.25	27	785	2009-01-15 18:05:59	2003-09-10 13:16:00	6	1	783	13	90	230	8	44.00	72	58.77	CHANGED	HcAPsDLSLMlLGNhlTNllsppV.sssQRtslA-pFucALtpSl	..HKAPTDLSLMVLGNMVTNLINTSl.APAQRQAIApSFAcALQSSI.	0	8	28	61
+7037	PF07209	DUF1415		Protein of unknown function (DUF1415)	Moxon SJ	anon	Pfam-B_16932 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	20.90	20.90	23.20	22.60	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.19	0.71	-4.53	56	495	2009-01-15 18:05:59	2003-09-10 13:18:37	7	3	477	0	142	398	77	170.90	45	88.00	CHANGED	pptlls.pTcpWlccsVlGLNLCPFA+p.ht+spIRasVo-AsshcslLpsLhpELphLttssst-l-.TTLllhPps..LpDFhDYpDhlDhA-sLLtphsh-GlhQlASFHP-YpFsGsssDDspNaTNRSPYPhLHLlREsSl-+AltsaP-.sEsIPERNIphhccLGt-....tappL	.........................p..tlltpTcpWLpcsVIGLNLCPFA+tshh.+....pp...........lRhhVS-Aps.-s...lLp..-LhpELptL.tt...ssspcl-.TTLllh.Pph....hpD.FhDYND.hl.-hA.-sll..pp..s..hEGl.....hQlAoFHP-YpFs...Go...-....sD.DhpNaTNRSPYPhLHLlRE-Sl-+Alps...a.P.D....s-sI.E+NIsplccLGt-thpp.h..................	0	41	83	116
+7038	PF07210	DUF1416		Protein of unknown function (DUF1416)	Moxon SJ	anon	Pfam-B_16939 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family appear to be Actinomycete specific. The function of this family is unknown.	22.10	22.10	22.10	22.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.84	0.72	-4.37	9	209	2012-10-02 19:08:27	2003-09-10 13:24:12	7	3	183	0	68	190	15	85.90	65	81.51	CHANGED	sulDltKEsVIpGpVh.psGpPVssAYVRLLDusGEFTAEVsoSAoGpFRFFAAPGoWTVRALsssusu.-tpVsAcsuslppV-lsV	.........AuVDlEKETVITG+Vl..suDGpsVGGAFVRLLDSosEF.TA.EVVASATGDFR....FFA.AP..GoWTLRALSsuGNG...Dus.VpPsGuGlHE.VDlpl........................	0	23	53	63
+7040	PF07212	Hyaluronidase_1	Hyaluronidase; 	Hyaluronidase protein (HylP)	Moxon SJ	anon	Pfam-B_16578 (release 10.0)	Family	This family consists of several phage associated hyaluronidase proteins (EC:3.2.1.35) which seem to be specific to Streptococcus pyogenes and Streptococcus pyogenes bacteriophages. The substrate of hyaluronidase is hyaluronic acid, a sugar polymer composed of alternating N-acetylglucosamine and glucuronic acid residues. Hyaluronic acid is found in the ground substance of human connective tissue and the vitreous of the eye and also is the sole component of the capsule of group A streptococci. The capsule has been shown to be an important virulence factor of this organism by virtue of its ability to resist phagocytosis. Production by S. pyogenes of both a hyaluronic acid capsule and hyaluronidase enzymatic activity capable of destroying the capsule is an interesting, yet-unexplained, phenomenon [1].	25.00	25.00	37.30	56.60	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.75	0.70	-5.40	2	54	2009-01-15 18:05:59	2003-09-10 13:38:03	6	2	22	8	6	52	2	239.80	70	77.07	CHANGED	NKPslsthApK.ETspKlpp....KADKpsVYhKAESK.ELDKKLsLpGGlhTGQL+hKPsuslthSSSTGGAlNIDhSpS+GAuhVhYoNpDToDGPLM.LRosK-TFsQSs.FVDY+GpTNAVNIsMRQPoTPNFSSALNITSuNEsGSAMQlRGsEcALGTLKITHENPSlcAsYDKNAAALSIDIVKK..osGtGTAAQGIYINSTSGTTGKLLRIRNhNcDKFYVpPDGGFauhtsS.lDGNLplKsPhuN-HAATKtYVDtcltcLKtLlstK	.......................................NKPslsuhApKpETssKIscL.S.KADKssVYhKAESKhELDKKLsLpGGlhTGQLpFKPN.SsIc.SSSsGGAINIDMSKScGAuhVhYoNpDToDGPLM.LRosK-TFsQSA.FVDYpGpTNAVNIsMRQPoTPNFSSALNITSuNEsGSAMQlRGlEKALGTLKITHENPslcApYDcNAAALSIDIVKK...psGpGTAAQGIYIN.STSG.TT.GKLLRIRNh.s-.DKFYVpsDGGFauttsSplDGNLplKsPTuscHAATKsYVDpclpcLKtLl.cK.............................	0	1	5	6
+7041	PF07213	DAP10		DAP10 membrane protein	Moxon SJ	anon	Pfam-B_16910 (release 10.0)	Family	This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells [1].	20.80	20.80	20.90	21.50	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.76	0.72	-4.23	3	40	2009-01-15 18:05:59	2003-09-10 13:48:29	6	2	25	0	16	39	0	71.20	48	94.25	CHANGED	MlPPGHILFLLLLPVAAAQTTPGSCSGCGPLSLPLLAGLVAADAVsSLLIVGVVFVCARLRSRPAQEDGKVYINMPGRG	...............M...GtlLhL.L.L...LsV...uA..sQ..............sos..............G..SCSGCGsLSLPlLAGLVAADAVhoLLIVssVFhCAR...RppPsp.ccs+VYlNMPsR...............	0	2	3	6
+7042	PF07214	DUF1418		Protein of unknown function (DUF1418)	Moxon SJ	anon	Pfam-B_16971 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 100 residues in length. Members of this family are often described as YbjC. In E. coli the ybjC gene is located downstream of nfsA (which encodes the major oxygen-insensitive nitroreductase). It is thought that nfsA and ybjC form an operon an its promoter is  a class I SoxS-dependent promoter [1]. The function of this family is unknown.	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.39	0.72	-4.36	7	515	2009-01-15 18:05:59	2003-09-10 13:56:04	7	1	507	0	26	140	0	94.00	67	98.88	CHANGED	MRolGsLP+sVLILEhLGMlLLslAhLSlNpYLoLPushuoPpAullMIFlGlsLMlPAAlslhWRlAphhuP.L.....hs+PPp.sp....otc-KpsDusH	.....MRuIGcL..PKuVLILEaIGMhLLAVAL.LS.ls-.L.SLPcPFupPp..............lt............ILMIFLGVLLMLPAAVlllhpVAKtLAPQL.....MsRPPphSc......S-REKcNDuNH................	0	1	5	16
+7043	PF07215	DUF1419		Protein of unknown function (DUF1419)	Moxon SJ	anon	Pfam-B_16972 (release 10.0)	Family	This family consists of several bacterial proteins of around 110 residues in length. Members of this family seem to be specific to Agrobacterium species and to Rhizobium loti. The function of this family is unknown.	21.60	21.60	21.70	22.30	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.60	0.72	-4.20	15	46	2009-01-15 18:05:59	2003-09-10 13:58:33	6	1	32	0	27	48	1	105.70	53	56.29	CHANGED	Ms..sPlRKVFpGVAcRcQMFRhFDRHuQRPsRacuDsusLYsGEWFEIspspHDYMhEILPPLWMRu-MFAMREFLTGslTSVFFsL+IDGRhRaFHGYCDLSD+sSPEcM	.................p..sshRKlapGVAsRpQMFchFDRHsQcPsphcsDsusLYsGEWFEIucspHDYMhEILPPLWhR....G....sMFAMREFLTGolTSVFFsLpI.DGphRaFHGYCDLuD+uSsEcM..............	0	2	15	20
+7044	PF07216	LcrG		LcrG protein	Moxon SJ	anon	Pfam-B_16974 (release 10.0)	Family	This family consists of several bacterial LcrG proteins. Yersiniae are equipped with the Yop virulon, an apparatus that allows extracellular bacteria to deliver toxic Yop proteins inside the host cell cytosol in order to sabotage the communication networks of the host cell or even to cause cell death. LcrG is a component of the Yop virulon involved in the regulation of secretion of the Yops [1].  	21.70	21.70	23.00	24.80	21.20	19.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.10	0.72	-3.96	4	75	2009-01-15 18:05:59	2003-09-10 14:19:17	7	1	70	0	9	31	0	95.30	52	99.54	CHANGED	MKps..s-aoc.....TlppAELAItDSDcRscLLpEMhtGLGluspAsplLFtu...ssE.hpsAEpELLsElpRpRppQPp.QshpG+RsRRPThMRGhlI	.....................MKss..s-asc.....TlcpAELAItDS-cR.ucLLpEMhtuL.GLsPpAsplLFuG..tssE..h+sAEcELL-El+RpRppQPQ...ps..tcG+RPRRPTMMRGhlI	0	1	3	4
+7045	PF07217	Het-C		Heterokaryon incompatibility protein Het-C	Moxon SJ	anon	Pfam-B_16951 (release 10.0)	Family	In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an individual colony to form a network. Hyphal fusion can occur also between different individuals to form a heterokaryon, in which genetically distinct nuclei occupy a common cytoplasm. However, heterokaryotic cells are viable only if the individuals involved have identical alleles at all het loci [1].  	20.60	20.60	21.60	21.40	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	606	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.11	0.70	-6.32	20	311	2009-01-15 18:05:59	2003-09-10 14:28:57	6	5	127	0	157	385	0	398.00	44	72.79	CHANGED	Mushh....ssLLlhhll.LllLPspstAFGAGNIASISpVEG+NWRHGDIEDhLtTlAhh+.......G+KaoshhVKRVYFGNWLRDYSQAlDVGTLK.uVsA-TIRILVWVLuFhoFGYATuEFEVTsERLGsYRPEEHIDNPKsYADspDARcYDsRLRGPVcp.tEL-IDPcTGMKNYIANE....sGGW.uTSAuYlRhohuRsIHaGRhYo.....cpGp-pDLpEALRhLGQuLHsLED.FuAHoNYsELALhEhGa+s......VFPHsGssTplpl.pG++..VYPLVTGTFGuVDFlHSVLGEAoDHhTQSElsEl-tALssAcssssss......................s.uslpuLLuKlP..........G.....sGDshsscA--LcppSpAQptpNpp..t............................................t.s...lsshpP-h.......ssh...cshtQIYPILEFRDclV+uIsshI...EKIPGLpsLlEpIoEsLTlFVhoLLAPFl+PIIsploppLpsGSSuVIsoStpcQaEsWssspCoDPTHSMLSKDHFSNlLNEPAG+VASsIlpYVVPRllhAW-ssslsscpVl--hLp.VFHHPAlRs.....psEh+RpMFcsVcpWhpspscctpc.LpchLSuEGV+sG+N+......psGspspuHupGpshshsts..s................uputsuuuhhpphppp	...........................................................................t................................................................................................a.......................................................................................................................................................................thcs..l.......................hthD..ouhKtYl.....t.........t.......h..TSsshl+h.ht+sIchGRhYs.....tpspctDLhEALRhLGpuLHsLE.D.FsAHSNYsELuLh-hGp+p.......VF.PHVGssTplpl......p.....G+p................VaP....LVTGTFGuVDFlHSVhGE..hsD+h...o.....QsElpphp.tl.tupt.tt..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	47	88	130
+7046	PF07218	RAP1		Rhoptry-associated protein 1 (RAP-1)	Moxon SJ	anon	Pfam-B_16981 (release 10.0)	Family	This family consists of several rhoptry-associated protein 1 (RAP-1) sequences which appear to be specific to Plasmodium falciparum [1].	20.50	20.50	251.30	106.30	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	782	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.51	0.70	-6.44	2	109	2009-01-15 18:05:59	2003-09-10 14:37:53	6	2	16	0	7	110	1	637.70	65	99.73	CHANGED	M.hhluSLlllFasLapNVusGIslNG-pphspph.sp-FN.DDhN.Wh.lsctpFLNoapcphSs.SFlEsKuSh-sG.......SpsscuSppGpG+...............DShsDhpFhss.s.s.KsupPpuspspu.tSSSsupopuSu.SssKSuS.aGtSs.S-.SshcSuptSu.....VGucE.t...........pEhY......FshpashpphpcphsILKN-hshVtpcEth.hDEphcchcpc+Kcth.KhhtEuD.E..hhsEp.pFlcpphp-ppltGuFocFhSpLNPFKK-.h..KpElShhTa..Is.plssKE..h+sLGlutpYp.Y.pohLYsCPNss.hFDohEsLptcl.c.+c+Euhhsphh-ppKECLKNhGlhDhELsDspsKhGssIGShGEhHlRLYEhENDLhKapPslDYhTLADsYKL.KNcl.pLppVNFCLLNPKTLE-FLKKKEIh-LM.G-D.ItYcEpFspaMp.SIsCHlESLIY-Dl-uSQDhthVLK.sKSKLallpsGLoYKu+KLl.KlasEIQKNP-.laEKLTWIY-NhYhlKR.aThhAhcsVC.pYlpHs..phYTpLp.hhshIl-.sRhYuuCFKNlhlYNAlISGIHEphKphhKLhPRpshL.DhHFpulhcKE.K..KhhpTsalh..aDPoVtuYAhhpl-RhsMVolINsaFEAKKKtLohhlupMKhDhholpNE-.KIPNDKuANSKLss+LhphaKAEI+caFKEMR.pYshLIphRY+uHhKKNYhhaKRL-	.............................SLlllFasLapNVusGIslNG-pphupph.sp-FNhDDhN.Wh.lsccpFLNoapcphSs.SFLEsKSSh-sG.......SssscuSppGpG+...............DS+sDhpFhAsss.s.KTSpPpuspsuu.+SSSsup...o+uSS.SN........s....KSuS.aGcSspS-.SshcSuppSu.....VGucE.s...........cEhYs.....FsYKashsphpcpIsILKNEhshVtpcEth.hDEphcchcpc+Kcth.Khht-oD..E..hhsEp..pFlcpphp-ppltGuFocFhSpLNPFKK-.h..KpElShhTa..Is.plspKE..h+sLGluhpYp.Y.pohLYsCPNss.hFDohEsLptcl.c.cc+Euhhsphh-p.pKECLKNhGlhDhELsDspsKhGssIGShGEaHlRLYEhENDLhKapPslDYlTLADsYKL.KNcl.pLppVNFCLLNPKTLE-FLKKKEIh-LM.G-D.ItYcEpFspaMp.SIsCHlES...LIY-Dl-u..........SQDht...h....V...L.K.sKSKLallpsGLoYKu+KLl.KlasEIQKNP-.laEKLTWIY-NhYhlKR.YThaAhcsVC.pYlpHs..phYopLp.hhshIl-.sRhYuuCFKNlhlYNAlISGIHEphKphhKLhPRpshL.DhHFpulhcKE.K..KhhpTsalh..aDPoVtuYAhhpL-RhsMVolINsaFEAKKKtLohhlupMKhDhhSLpNE-.KIPNDKuANSKLss+LhphaKAEI+caFKEMR.pYshLIphRY+uHhKKNYhhaKRL.....	0	1	2	5
+7047	PF07219	HemY_N		HemY protein N-terminus	Vella Briffa B	anon	Pfam-B_16745 (release 10.0)	Family	This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis [1].	28.20	28.20	28.80	30.00	27.00	26.60	hmmbuild  --amino -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.08	0.72	-4.50	19	1471	2012-10-11 20:01:00	2003-09-10 15:05:05	8	28	1455	0	312	955	302	108.30	35	26.03	CHANGED	GhVhIphsuhph-sSlhtslhhllhhhsslhl.......lhhllpplhpsstpsptahcpp+RcRuppulppGlhshupGchstAc+hht+u.uch..s-pssLthLhuApAAptpGc	...............GYVlIp.hss.a.pI..Es.Slssh.llhlllshlllah.......l.hll+plhpsss+spsa.assRKc+RAcpthppuLlcLuEGDa....ppuEKhhs+...s...Acp.............u-p...P.........slshL.lAAcAApppGD......................................	0	64	156	231
+7048	PF07220	DUF1420		Protein of unknown function (DUF1420)	Moxon SJ	anon	Pfam-B_17056 (release 10.0)	Family	This family consists of several hypothetical putative lipoproteins which seem to be found specifically in the bacterium Leptospira interrogans. Members of this family are typically around 670 resides in length and their function is unknown.	18.10	18.10	18.40	18.40	17.80	17.30	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.19	0.70	-6.16	2	13	2012-10-03 03:08:05	2003-09-10 15:58:07	6	1	9	0	3	11	68	573.50	57	99.04	CHANGED	MKFGLDANlsYPPLSVlYSIhLIhGCDFLGFYILKLFEspLGclKNTWhRWQAPLhGALLLSV.LYPLAL.uhTsRhhMcSsAhhLslLGhhNlshFlKphppNhs.lsh.p.Nl.+Slpap..h-h....cp.K+sF.LFK.hh.hhsKFsLIshNchLNlFIhLLhluYGhLALCPlTNADSLDYHIGVAIEILNQGKMPsF.GWFHGRLAGSGEVLNALGLAIGAEQFGSLLQFsGLLuIYGILuFYSFhEK..tsDG.VWRcIIIIAFLSSPVLVFLVSSsKPQLLQlGMTSFAlsLLLEIhSKhKTDKNKL.hF.LICILIMSsTQAKFSFFLSAFLIGLhSlh.LGSIRLahYGlLIulFFhlLI.FPulFWKIKNasSohIDsllhPLPG.saPGVppFEssLRNYpDSsL.FPLSLlhPNpFGVlTTlIG.GLFLlIFVKPIss.psFlLShhIIlFVILG.LhGQpASRFFLEPFlWhLISLIslsshth.Nl+Fs+psluhhllLQAshThsIl.lGIYQLhPGVFSIp.REKVMsQYuNGYsLMKWsG.sLPK-AVLLSQHRSlALSERKTLSLDWh.FVsFsShlASPYL+pIKDENVTHILhhG-hSKsoPF.GCIGNsIGKTKSp.shRNPhs.pDaFTsILsEFp.spLsQCuN.lL	..........................MKFGLDANlsYPPLSVlYSIhLIhGCDFLGFYILKLFEspLGclKNTWhRWQAPLlGALLLSVlLYPLAL.uhTsRhhM+SsAhhLslLGhANIshFlKphppNhsSlsYhp..Nlh+SlpapS.h-h....cp.K+sF.LFK.hh.hhsKFsLIspNchLNlFIhLLhluYGhLALCPITNADSLDYHIGVAIEILNQGKMPsF.GWFHGRLAGSGEVLNALGLAIGAEQFGSLLQFsGLLuIYGILuFYSFAEKF.psDG.VWRcIIIIAFLSSPVLVFLVSSPKPQLLQlGMTSFAlsLLLEIFSKhKTDKNKLhhFS.LICILIMSsTQAKFSFFLSAFLIGLhSlhpLGSIRLFFYGlLIulFFFlLI.FPulFWKIKNasSoaIDsllpPLPG.saPGVppFEssLRNYpDSsL.FPLSLlaPNpFGVlTTlIG.GLFLlIFVK.PIVsp+sFlLSlhIIlFVILG.LhGQKASRFFLEPFlWhLISLIsLsShup.Nl+Fs+psluhhllLQAshThsII.lGIYQLFPGVFSIplREKVMSQYANGYoLMKWsGhsLPK-A.VLLSQHRSIALSERKTLSLDWh..FVDFsStlASPYLKpIKDENVTHILhaG-TSKsoPFpGCIGNsIG..KTKSppVsRNPFN+pDaFTsILsEFp.DpLPQCuN.lL................	2	1	2	2
+7049	PF07221	GlcNAc_2-epim		N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)	Vella Briffa B	anon	Pfam-B_17012 (release 10.0)	Family	This family contains a number of eukaryotic and bacterial N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) enzymes (EC:5.3.1.8) approximately 500 residues long. This converts N-acyl-D-glucosamine to N-acyl-D-mannosamine.	19.90	9.10	19.90	9.10	19.80	9.00	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.40	0.70	-5.43	20	1825	2012-10-03 02:33:51	2003-09-10 16:14:30	6	21	1288	23	552	1700	239	297.20	21	69.11	CHANGED	Gh.Fp...p.LctcGpshsssc..tchhspsRplasFAhAtt.h.G.hsG.hh.s.h...ssHGlcaLppshR..DsppG...Gaahsl..s.ssu.s.hDssccsYsaA...FllhAhus.A...htuGts...cA..cshh...s....cshsll......-p+hhctctsh.ht-phstsashh...........G....pNsp..MHhhEAh.LAhh-sos..-tp..aL........spAtplschhhpchhs.....tsshhlhEaFchpWss..shst-...t.hcshhhpPGHthEWuhLl....lp....l.t......ttptsschl.spAcpLattulspuhshctu.GlsYh.hshpupsss....ps+h..hWspsEsltAA...stLtpt.oG-..pc...YhphhpphhshhtpahhD..t.hGtWacplstcsp..lspsl.uuposhYHhhsA	..................................................................................................................h.at.h.hs.t.p.G.p..h.t...t....thhhpsR..............lasau...huht.....h........s......p...st....hh...p..h...............scp.uh.c....hh.p.t.t.h.t.....Dt..phG..............G..a..a.htl..............s.stt...s......hc...t.......p.....+..p......hY.....sps..............F.....s...lh..uhup...s..........h.t.s.G.p.s....ps..p..ph..h...p...pshphl...................pchh.hs...t.t...t....s.h...hh.pp.h.s.t.shp..............................ps........................tN.s.t.....M.Hhh..E.uh...l.....h....h.h.c....s..pt.............-tt.......ah............................pph...pl....hph...hh....p.phhp...........ttp.h...h.l..Ehh....t..........ps...thp.............................s..h............hp..P........G.H.h...E...huhLh..........hp....ht.....................t.tt.....thh....tt....A.......t.l.......h....t...h...s..h...p...t...u..h..........s....p........t...u...Gh....h....hh....h..s.h...p...s.p..shs...................pp+h....hWs.s....Esh..hsh.............h.h..h...h....ph........o...uc........tp.............h..ph.hpph...hp.a.hh.p.ah..h...........D....p............G.t.W.a.t...l...stpsp...st.t...t.........s...............................................................................................................................	0	172	349	448
+7050	PF07222	PBP_sp32		Proacrosin binding protein sp32	Moxon SJ	anon	Pfam-B_17278 (release 10.0)	Family	This family consists of several mammalian specific proacrosin binding protein sp32 sequences. sp32 is a sperm specific protein which is known to bind with with 55- and 53-kDa proacrosins and the 49-kDa acrosin intermediate. The exact function of sp32 is unclear, it is thought however that the binding of sp32 to proacrosin may be involved in packaging the acrosin zymogen into the acrosomal matrix [1]. 	20.70	20.70	98.50	21.10	18.80	19.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.79	0.70	-5.19	3	56	2009-01-15 18:05:59	2003-09-10 16:20:49	7	3	28	0	25	44	0	194.90	54	48.61	CHANGED	Mh+sAAGFLLMLLcVLLLPLoPsoAE-STPASTPGSPLSsTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSNLPYASWFESFCQFA+YRCSNHVYYAKRVhCSQPVSILSPNTLKElEuSAEVsPTTMToPIusHsTlTE+QoFQPWPERLsNNVEELLQSSLSLGGp-Qssu...t+PKQEQhlp++QE.lQEHKpEEuQcQEEQEEEE..cEEEAKQEEGQGT--	.........................................p.Asu.l..LLcVLLLshs.PssAp-o...u.sTPGSPLSsoEYERFFuLLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSsLPYASWFESFCQFsQYRCSNHlYYAKR..VhCSQ..PlSlLSPsoLKE....l-sssEVs.soo.hT.sP.hss+hpsTE.pQs.psWs-RLpsNlc...cLLpuuhSLsGpcp..t..........tpc.....+tQt.http..pttp..p-Qtc.............................................................	0	1	1	11
+7051	PF07223	DUF1421		Protein of unknown function (DUF1421)	Vella Briffa B	anon	Pfam-B_17006 (release 10.0)	Family	This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.	29.00	29.00	29.30	29.30	26.90	28.40	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.77	0.70	-4.67	9	104	2009-12-15 14:25:35	2003-09-10 16:29:41	6	4	24	0	56	102	0	285.30	31	67.71	CHANGED	L+EVQsuVQlL+DKQEIsETQhpLuKLQls+tp..ppscspu.ps-sptpsssP..ht.p..t.hP..phshAhP......u.........lPss.us.Ps.p.psQ..........Psp.Qh..........................................................P.phPsp.lp.....s.P...........ttpPaasPP...u.QsptsPsQQ.....hp..PP.........................Q.tPsPtsPppppY....QsPPQhsQhpQ..............sPsPQ...hP.sssh.Pc....PY....tuhPPs...Psshs.p.P.usssP...hasss...sthYsssuuhPso.s..pt..PPP..t...............YshSGsPsp.u........usssatPptsup...utusuY...PphssAp....LPQuhshuSuP.shtt.....SspShpptPlsDll-KVsoMGFsRDQVcuslp+lTEsGQsVDhNslL	............lpEVptuVQlLpDKQElsEsphpLuKLQhsptp...pptp..ts.......h.p..ss.s..............h.........s.h.s...........s..............ss.........sp...................................t.p...........................................................s.p.s........................................hhs.s....t..p.......ssQQ......p...s..............t..t.s.P....s..pph...........Q..s..sQ.......Q......................pss...p...h...ss..............P.......Pa......s.sss......s.s.........s.s...s.....h..t.s.........h.ts.....sh.................sst....t................s........................a..su....s......s....s.......................hts.t.st.....shtss.Y....sp...ssAp....hPpt.....ssss.................ustshpphshs-hl-KlssMGas+-pV.puslp+hsEsGQslDhNslL..........	0	8	34	46
+7052	PF07224	Chlorophyllase		Chlorophyllase	Moxon SJ	anon	Pfam-B_17130 (release 10.0)	Family	This family consists of several plant specific Chlorophyllase proteins (EC:3.1.1.14). Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyses the hydrolysis of ester bond to yield chlorophyllide and phytol [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.96	0.70	-5.63	4	48	2012-10-03 11:45:05	2003-09-10 16:40:43	6	3	28	0	29	968	169	233.40	35	75.56	CHANGED	sSssohssFpcGpapssplsl-............ssp.ssssPPKPLlIsoPsEtGsYPVlLFlHGhhLpNp.YSplhsHIASHGFIVVAPQLaplhP...PuspsElcsAApVhsWhs.sLpthLP...ssVpuNlphhAlsGHSRGGKTAFAlAL...Gau.....plpFSAlIGlDPVAGTuKsppTsPplLTYcPsSFsLs.IPVsVIGoGLG..thsshhssCAPsslNHcEFapECK.uspuHFVAsDYGHMDMLDDsh.uhhuh.huthhCKNGpc.+ssMRRhlGGIVVAFLpsahcsDsp-hhtIlts.ShuPhpL..usEhcsssshh	.................................................................h......ssFp.G.ht..sp.hplt.............................ss...sP+......sL..h.l...h..sP...s..........t..G...s..a..PV.llFhH......G......h....h.....l.......h....N.....p......a.....Y...s.....p....l...ht....H....l...u.S.......H.G...aI.l..l...A........P.........Q........l....h........p....h....hs..................s...s..s................p.......-.....l.....c.........t........s...u..............p...........l......h...........s..........W......l.....s.....t......s..........L....t...t........h..L.P..........................t...V..p....s......s........l...p..+........l...slsGHS+GG.+.sA.F..A.lA...L.......shu....................plp.h...u...s..L.l.G.lD..P....V....sG.....hs.K.....t...p.h......P.l.......L.s....h...sp.SF..sh..s....hP........s.hV..I..GoG..L..G..........h....s.s.......CAP...tthNH..tpFa.cCp....st.a...Fl.stcYGHhDhLDD.....s.....h.u.....hhC.p..p.u.p..t...+p.MRchsuGlhVuFLps.h..sp....t.th..Ih....t........................th.....................................................................................................................................................................	0	4	20	26
+7053	PF07225	NDUF_B4	NDUFB4; 	NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)	Moxon SJ	anon	Pfam-B_17132 (release 10.0)	Family	This family consists of several NADH-ubiquinone oxidoreductase B15 subunit proteins (EC:1.6.5.3). 	20.70	20.70	20.90	21.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.49	0.71	-4.32	10	149	2009-01-15 18:05:59	2003-09-10 16:45:59	7	1	114	0	79	140	1	106.10	34	93.10	CHANGED	cYKsuPLuoLPpTLDPsEY.slSPEpRRApsERLAlRApLKRcYLLQhNDP+....R+ulIED.......PALsRWsaARshNlYPsFRPTPKTSLLGllaGhGPLlFWYaVFKTDRD++-chIpcG+L....DRsFslSh	...................................a.thS.-tpch..pRhthRspL+ppYhhphssPp.....ct..ull..D.......PALhRa.aAps.h.shY.pFRPTP...Ksu.hlG.h.h.h.uls.Pl..hhhhhshKo-RDtpcp.hppGph...c...........................................................	0	20	32	55
+7054	PF07226	DUF1422		Protein of unknown function (DUF1422)	Moxon SJ	anon	Pfam-B_17087 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 120 residues in length. The function of this family is unknown.	20.80	20.80	20.80	23.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.37	0.71	-4.36	14	660	2009-01-15 18:05:59	2003-09-10 16:54:00	6	2	654	0	56	195	3	115.90	70	97.14	CHANGED	Mspps.....ppE+tTLlLALlAGLshNushusLhoS.VsFSlFPlIALVLulYsLaQcYLppshspshPhlusAsFhlGlhhYSAllRApYPplGSNFhPhllulsLlFWIGhKLthhpppt	.........M..KQu.sQD+GTLLLALlAGLSINGTFA...ALFSSIV.PFSVFPlISLVLTVYCLHQRYLNRTMPVGLPGLAAACFILGVLLYSTVVRAEY.PDIGSNFFPAVLSVIhVFWIGtKhRNRKQ.-s................	0	3	15	34
+7055	PF07227	DUF1423		Protein of unknown function (DUF1423)	Vella Briffa B	anon	Pfam-B_17028 (release 10.0)	Family	This family represents a conserved region approximately 500 residues long within a number of Arabidopsis thaliana proteins of unknown function.	25.20	25.20	25.40	25.40	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.80	0.70	-5.82	10	189	2009-01-15 18:05:59	2003-09-10 16:56:15	6	7	34	0	96	177	0	301.30	29	51.54	CHANGED	AREpV-llA-+M+chP-EaLEcLKpsLRuILEG..sup++-EhhhLQ+hVQoRSDLTscTLs+AHRVQLEILVAI+TGIQsFLHsslolSQssLlEIFLYKRCRNIACpStLPAD-CcCcICoN+cGFCsLCMClICsKFDFuVNTCRWIGCDlCSHWTHTDCAIR-u.IssGsSsK.uusGsuEMhF+CpACs+TSELhGWVKDVFQpCAPsWctEoLl+ELDaVs+IF+uSEDsRG+pLFhKs-ELl-KLKuplA-s.sAs+hILtFFQEl-.Duu+ShEss.-suRhI..APQ-As..N+IApVVpEulcpMphVu-EKhRhhKKARhul-sC-+ELc-KA+clupLchERp+KK.QlDELEoIVRLKQAEA-MFQLKAsEAR+EAERLpRIslAKo-KsEEEYASpYLKh+LsEAEAEKpaLaEKIKhQpcSp+s.pu.....GcssphhMhSKI+-LL	.........................................................h......................................................................................................C+Nh..sCps..l.sspth.Cp.lCsppsuFCptChCslC.p+.F.D.sh.s.....ssp.WlsC........D........h......CuHhsHs-CAl+cthht.G.shp....ushu......h-h.FpChuCs+so-l...h.G.aVKclhphs.t.shph-sLh+cLphsp+lhpuScc.+...u+pLh.hscphht+Lc.st............................................................................................................................................................................................................................................................................................................................................................................................................................	0	14	63	81
+7056	PF07228	SpoIIE		Stage II sporulation protein E (SpoIIE)	Vella Briffa B	anon	Pfam-B_17063 (release 10.0)	Family	This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.18	0.71	-4.60	173	6344	2012-10-03 01:39:20	2003-09-11 09:29:08	7	400	2137	23	2480	8434	1928	192.30	20	35.38	CHANGED	sssphslsluDVhG....+GlsA..Ahhhshlpssl+shs.tpshs..............................Pspllpclsphl.tphpss........................hasTshhsh........h-.tstplphssAGHss.sllhps.ts........sshhhh.tssGhs..lGl.ss..................hshpstphpLtsGshLllaTDGlh..........Est.....shssth....phl..phhtt............spphsctlhpplhp.....................hs..phpDDhsllll+hp	.................................................................................................................................................................t..sphtlsluD.sh....G.........+G...l...s..A....A..h.h.h.....s..h...l.....p........s....h.....h.....c...s..h....s...p..p..s..hs...............................................................................ssp.ll...p.p....l.s.......ph.l.......t.p.hpps..................................................................hh..s.T...h..hhsh......................h-........p....s........t.......p........l....p..h.....s..s.AG.H..ss..s.h.l..h.cs...t............................ps.h.hh.h....t.s....s..u...hs...........l.G..l.....ss.....................................................hph..p..p..t...p....h...p....l...p..s...G....-.......h.l..llhTDGlh.........................................Esh.................s.ptp.h....h..t...p..phh..................phltt...............t.s......spp..h..hpt.l.h.ptltp.........................................htt.t...t.hpDDhsllhhch.t.....................................................................................................................	0	977	1887	2293
+7057	PF07229	VirE2		VirE2	Moxon SJ	anon	Pfam-B_17380 (release 10.0)	Family	This family consists of several VirE2 proteins which seem to be specific to Agrobacterium tumefaciens and Rhizobium etli. VirE2 is known to interact, via its C terminus, with VirD4. Agrobacterium tumefaciens transfers oncogenic DNA and effector proteins to plant cells during the course of infection. Substrate translocation across the bacterial cell envelope is mediated by a type IV secretion (TFS) system composed of the VirB proteins, as well as VirD4, a member of a large family of inner membrane proteins implicated in the coupling of DNA transfer intermediates to the secretion machine. VirE2 is therefore thought to be a protein substrate of a type IV secretion system which is recruited to a member of the coupling protein superfamily [1]. 	25.00	25.00	35.30	34.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.89	0.70	-6.11	4	10	2009-01-15 18:05:59	2003-09-11 09:47:11	7	1	7	1	4	10	0	533.60	58	97.82	CHANGED	MDPpupssutN.s.ph.tshtsts.ss.Ktp++cslsSoohs-IpMTsupEThE....GoPs+T-sluspLDt-.lDSpSStsSuSscGNQuElppELSuLFupMs.LPGpDRRsDEYILVRQTGpDtFsGTsKGsL-HLPTKAEFNAuCRLYRDGAGNYYPPPLAF-RIsVPspLpspht.hEs+-psK.pFQYKL-VWN+AHAEMGITGTcIFYQTDKNIKLD+NYKLRPEDRYlQT.+YGRRElQKRYpHpFQAGSLLPDIhIKTPcNDlHFVYR.AGDpYANKpFpEFE+hIKp+YGS-TEIKLKSKSGIMHDSKYLESWERGSADIRFAEFAGENRAHN+phPtATVNMGpQPDGQGGhTRDRaVSV-aLhQshPNSPWuQALK+GELWDRVQlLARDGNRYhoPpRLEYSDPEHFsplMsRVGLPtSMGRQSaAsSlKFEpFssQAAVIVAsGspLRDI+DLSsEcL.QQloppcVLlADRNEpGQRTGTYTSlsEYcRLhh+LPsDAApLLuEPsD+YSRDFVRP-Psh.PIsDSR..RsYEsRsRuQoVNuL	...............................................................................................MDPpu.ssucNls.stttshpsss.scsKRpK+cslsSoThsDIpMTsupEThE...pGSPT+TEslus+LDts.lDSpSStsSuSsHGNQuElppELSuLFuNMu.LPGpDRRsDEYILVRQTGQDtFsGTsKGNL-HLPTKAEFNAuCRLYRDGAGNYYPPPLAF-+IsVPtQLpspht.hEsKEpsK.RFQYKL-VWN+AHAEMGITGTcIFYQTDKNIKLDRNYKLRPEDRYlQTEKYGRREIQKRYcHpFQAGSLLPDILIKTPcNDIHFVYRFAGDsYANKpFpEFE+sIKp+YGS-TEIKLKSKSGIMHDSKYLESWE.RGSADIRFAEFAGENRAHN+QFPsATVNMGpQPDGQGGhTRDRHVSVDaLhQsAPNSPWuQALK+GELWD....RVQlLARDGNRYhSPsRLEYSDPEHFTpLMNRVGLPsSMGRQSHAsSlKFEpFDuQAAVIVAsGPsLRDI+DLSsEKL.QQLop....KDVLlADRNEKGQRTGTYTSVAEYERLhh+LPsDAApLLuEPoDKYSRDFVRPEPAh.PISDSR..RsYESRPRuQoVNSL........................................................................	0	1	3	3
+7058	PF07230	Peptidase_S80	Phage_T4_Gp20;	Bacteriophage T4-like capsid assembly protein (Gp20)	Moxon SJ	anon	Pfam-B_17388 (release 10.0)	Family	This family consists of several bacteriophage T4-like capsid assembly (or portal) proteins. The exact mechanism by which the double-stranded (ds) DNA bacteriophages incorporate the portal protein at a unique vertex of the icosahedral capsid is unknown. In phage T4, there is evidence that this vertex, constituted by 12 subunits of gp20, acts as an initiator for the assembly of the major capsid protein and the scaffolding proteins into a prolate icosahedron of precise dimensions. The regulation of portal protein gene expression is an important regulator of prohead assembly in bacteriophage T4 [1]. This family represents the protease responsible for the proteolysis of head proteins, a critical step in the morphogenesis of many tailed phages, Cleavage facilitates the conversion of the prohead to the mature capsid. All these cleavages are carried out by action at consensus S/A/G-X-E recognition sequences at 39 cleavage sites. Evidence of multiple processing sites in nine phiKZ proteins appears to represent a built-in mechanism by which the phage ensures that the majority of the propeptide regions are removed, and emphasizes the essential nature of processing in phiKZ-head morphogenesis [2]. The family is classified by MEROPS as a serine peptidase.	25.00	25.00	49.00	48.90	18.50	17.60	hmmbuild  -o /dev/null HMM SEED	501	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.58	0.70	-6.18	11	1179	2009-01-15 18:05:59	2003-09-11 09:57:38	6	2	283	0	0	965	2471	203.10	65	98.50	CHANGED	M........lcLFuhhhc.-p.phpcchpscstShssPcssDGAp-lps......uuasuhh.ph.Gs...thpspp-LIppYRplstpPEVDsAls-IVNEAIV.-.tsccsVpl-L.ssochSpslKc+IpEEFccll.clLsF-++upchFR+WYVDuRIaaHKlIDhcpPpcGItELRhlDPpplchlREhhpp..s..sGsplh+uhc.............EaalYssps.phs...hsuth.tuss.tl..KIs+DAIsYuHSGLhD..tscphlluYLH+AIKPsNQL+MlEDAhVIYRloRAPERRlFYIDVGNhPppKApQYlpsVMpphKN+lVYDusTGclKNpppthSMhEDYWL.RR-GtpsTEVoTLPGuQshG-h-DVcYFp+KLYcALplPhSRhss-s..uGhslGt.usEITRDEL+FoKFltpLpp+FpplFpD.LKTpLILKsIIT.-EW--.t-pIphsFppDsYFsElK-hEILppRlNhlspl-P..alGKYaSp-Ylh+cIL+hTD--Icp.ccQIEpE	..........................................................................................................................................................................................................................................................................................................................................................................................................................NLPKsKAEQYLRDVMsRYRNKLVYDAsTGE...lR.DD+KaMoMLEDFWLPRR.EGGRGTEIoTLPGGQNLGElsDl-YFpKKLY+uLNVP.SRl-s..-s...G..F.N..L.GR.S..oEIhRDElKFsKFVuRLRKRFSplFsDhLKTQLlLKsllT.sEDW-p.M.p.-.HIQYDFlhDNaFsELKEsElhsERLshlst.........................................................	0	0	0	0
+7059	PF07231	Hs1pro-1_N	Nematode_res_N; 	Hs1pro-1 N-terminus	Vella Briffa B	anon	Pfam-B_17124 (release 10.0)	Family	This family represents the N-terminus (approximately 180 residues) of plant Hs1pro-1, which is believed to confer resistance to nematodes [1].	25.00	25.00	105.10	104.40	22.10	21.20	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.27	0.71	-4.69	5	36	2009-01-15 18:05:59	2003-09-11 10:30:34	7	2	19	0	22	37	0	176.50	48	40.19	CHANGED	MVDLDWKpKMVsS..DhPsKSPKLShpc.....slSlPp.hplPslSo-ISsAAPulCSAYEhYLRLPELRpLWSSp-FPpWsNEPILKPALQALEITFRFISsVLSDsRPYINRREWNRRLESLsTcQIEIIAsLCEDEEp...hRGouPsAsLSuG......................s.o.sppaSEhSLLPRLATWpKSE-VAQRILhoVE	..........................................................................hss.sl.p..ssssshstAYE.YLRLPELppLWpupsFPsWssEsllKPALQALEITFRhlSsVLSDPRPYhsRREWsRRLESLAspQlEllAhLCEs--p.....ttpAPhAcLSuu......................s.shspphSEsSLLPRLAoWpKScslAp+IhauIE.	0	8	16	19
+7060	PF07232	DUF1424		Putative rep protein (DUF1424)	Moxon SJ, Bateman A	anon	Pfam-B_17284 (release 10.0)	Family	This family consists of several archaeal proteins of around 320 residues in length. Members of this family seem to be found exclusively in Halobacterium and Haloferax species. The function of this family is unknown. This protein is probably a rep protein due to conservation of functional motifs.	20.20	20.20	23.00	22.10	17.70	16.90	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.03	0.70	-5.68	2	13	2012-10-02 18:54:06	2003-09-11 10:49:46	6	1	10	0	1	12	0	291.40	36	69.10	CHANGED	MApps....G.+LRcElThDTSRuV+AsShupAl-pFpuWYsDQRsTQhVVEpt.hGEpVGFchPNRFTPEYREMLYAKAQSLERGLREcWGsLLHTuMVTLTASoT---Gt.RP.l-HhcDLLpSWpAVhcALt+sLEsREaEYLAIlEPpp......uGYsHIHLGVFV+GPVVAEQFpsVLDAHl+Ns.sAGc-AHp.Vh--stDEsAVplRRSu+PsRpsGlENLGAYLAAYMAGEYGsEs.tMPtpVRAFYAsMWAoGpQWFRPSNGAQchMQPEp.D-t-SlEEWEMVGIAPEGDLtD.IIEVDPppPRsDPYRRLRTPPPGG	............................................................t.+AsoWucAlspFpsaasDtRssphshEsp..G....-psuhphP..sRFsP-YpchhYAKupuLER....GL....R..cc.......aG....phL......HTuMVTLTASSssps..G+.tPPl-H.......hc-Llc..SWcA......VR+AL.tRV......L-......u+......EW-YhsIhEPHp................uGYsHlHlGVaVcGs.....V.....VAEpFpPVlDuHVcNC.sAGc-AHp.h..h--..sts-csVpV+Rsup.sts..sGVE.......NLGuYLAAYMAG.YssEshEhPhphpAahAshWAouRQhhc.SsuApEhMps-.............................................................t..............	0	0	0	1
+7061	PF07233	DUF1425		Protein of unknown function (DUF1425)	Moxon SJ	anon	Pfam-B_17314 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 125 residues in length. Several members of this family are described as putative lipoproteins and are often known as YcfL. The function of this family is unknown.	25.70	25.70	25.70	26.80	24.40	25.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.96	0.72	-4.42	37	877	2009-01-15 18:05:59	2003-09-11 10:56:45	7	1	872	2	101	375	20	92.40	42	74.46	CHANGED	lhhssssLusplslsslpssps.sshhpussplpsphpsshplpYRFhWYDspGhplpsp.ssW+slhlpGppphplpulAssspAsca+lhl+p	.....................l.Vh-solLuAGlosEpPslo.sS..DhpssAoupL.h...NcppcPls.VpYRFYWYDscGL....E..h....+...P.L........E.t...sR.o..lsIPAcssVoLhusAshhsA+csRLYLa.L.	0	11	35	69
+7062	PF07234	DUF1426		Protein of unknown function (DUF1426)	Moxon SJ	anon	Pfam-B_17431 (release 10.0)	Family	This family consists of several Banana bunchy top virus proteins of around 120 residues in length. Swiss:Q9IGU4 is annotated a movement protein whereas most other family members are hypothetical. The function of this family is unknown.	25.00	25.00	189.00	188.90	20.20	19.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.56	0.71	-4.36	3	31	2009-01-15 18:05:59	2003-09-11 11:09:30	6	1	3	0	0	31	0	116.50	82	98.88	CHANGED	MALTTERVKLFFEWFLFFGAIFIAITILYILLVLLFEVPKYIKpLVRYLVEYLTRRRVWMQRTQLTEATGDuElsRulVEDRRDQQPuVlPasP+VIPP.QsR...R-DQAhRusAGPMF	MALTTERVKLFFEWFLFhuAIFIAITILYILLVLLFEVPKYIKpLVRYLVEYLTRRRVWMQRTQLoEATGDVElGRGIVEDRRDQQPAVIPpuSQV.PS.QsR...RDDQGRRGNsGPMF.....	0	0	0	0
+7063	PF07235	DUF1427		Protein of unknown function (DUF1427)	Moxon SJ	anon	Pfam-B_17474 (release 10.0)	Family	This family consists of several bacterial proteins of around 100 residues in length. The function of this family is unknown.	21.10	21.10	21.10	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.17	0.72	-3.91	32	341	2009-01-15 18:05:59	2003-09-11 11:15:13	6	2	240	0	124	290	13	72.20	43	92.05	CHANGED	KsYllSLuAGlLVGllYuLlsVRSPAPPlIALVGLLGhLsGEQllPls+phlsutthtst.httth..ph........ttttt.............ttppp.s	.....h.YllSLusGlLVGllYullpV+SPAPPll.A.LlGLLGhLlGEQllPhs+phhtt....................................t...........................	0	19	46	82
+7064	PF07236	Phytoreo_S7		Phytoreovirus S7 protein	Moxon SJ	anon	Pfam-B_17475 (release 10.0)	Family	This family consists of several Phytoreovirus S7 proteins which are thought to be viral core proteins [1].	19.80	19.80	20.30	20.80	17.10	19.70	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.56	0.70	-6.18	4	20	2009-01-15 18:05:59	2003-09-11 11:20:55	6	2	11	1	0	21	3	470.80	42	87.70	CHANGED	hsAIVCluLLoE+sVLoRsLsDpsKcFYpulpGphh.tscsl..Tc+huppSl.lR+lVPosTlILDaKsEsFI+pN.shSL.DIsGSPSNTAPKTsFpSIMPSLSsLFssPFlQGAFRHslISoh.GptTsLLILVVGPPSGF.cp.sVuSuuSsV-ssoNAcIDLsclVulNosMhppTpLVSAuulpAMulsDVhl+CsSLDplLlshAlKYF+sYVsshpsuuhspATpIhLNosFcELFslpsscpthlts-shtsspsphRGlVLPhGHGp..ssLpp+HP-lFI-.-ulFoc-E+ucLsch+hp..-sDsaEE...hFsphVpKalppGcYGN+VIluH+sspLsssGlpIlGhaplss.pslcpplp...ShKsclDhs+pNWctlpspshVsssTlppLHctIL.Dhhssospull.ss...uscspEtIslpFhNGFPpcKaullpLEKsGIpVVu..phsDss.lVlsNsPshVSRutKuptp......psRu+hDAtplslDTDclSpsphIphl+oh	.........MoAIVsVsLLSEpsVLsRsLsDhVKshYptlpGssssst-sI..pt+hospol.lp+hlPhsTVhl-ahDpcaIptNPshShM-IlGSsuNTAPKTTFQSlhPSLSALFGVsFIQGAFhHpVISop.GsphShLlLVlGPPusFh+psSVuuuSSlVpV-SsucIDLsDsVtINuhMlpsTKLVSASulpAhuls-V..KCsSLDshlIhpAlpYF+pYs.ttphGohDsATplhLNhPhcElFSsc..oupuc.Lpsc..sa+-.scupltGlVLPsGHGK..oTLsScYP-lFlplpt.hsc-cppth.....s...suDshEp...happhIp.pplscGcYus+V.lLucssccL.ssGl+llGsa+lss...spVccpls...shKschDphcpsWcshSG.shVoscslshLHDKlL.DllospsKulhhscp..........ph+scppIslhFKNGFP.t+aShspLpKpGIsVVp..-Ls-ss.lllsNtPppssRps.tpsK......sphpphcus.+VslDTDslop-phIsKlKs.L........................................	2	0	0	0
+7065	PF07237	DUF1428		Protein of unknown function (DUF1428)	Moxon SJ	anon	Pfam-B_17402 (release 10.0)	Family	This family consists of several hypothetical bacterial and one archaeal sequence of around 120 residues in length. The function of this family is unknown.	21.00	21.00	21.20	21.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.23	0.72	-4.12	72	547	2009-01-15 18:05:59	2003-09-11 11:24:00	6	3	516	2	124	281	36	102.90	66	86.44	CHANGED	sYlDGFVlAVPsuN+-sYpchAppAutla+.EaGAlchVEsWGD................DVPpG.........clTsF.pAVpscssEsVVFSWlhWPsKtsRDsuhp+hM....sDPRhps..s..sMP.FDGK	...pYVDGFVVAVPA-KKDAYREMAuKA.APLFK.EFGAL..RlV..ECWAs................DVPDG.........KVT.DFRMAVKAEEsEpVVFSWIEYPSKEVRDAANpK....MM....u.DPRMKE..hG-..sMP..FDGK.............	0	37	76	97
+7066	PF07238	PilZ		PilZ domain	Bateman A, Galperin M	anon	Pfam-B_17421 (release 10.0)	Domain	PilZ is a c-di-GMP binding domain [3] which is found C terminal to Pfam:PF07317.  Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias [5].  This domain forms a beta barrel structure.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.29	0.72	-4.00	191	5848	2009-01-15 18:05:59	2003-09-11 11:30:13	9	113	1860	15	1946	4774	350	102.40	16	32.82	CHANGED	ppRpt..........Rhphphss..................hhttsspth.........p.....sthhDlShuGh..tlph.....tp..thphsp...........l........plph.thsstth................................htupVhphptp..............thGl...pF.......ths.pptppltphlht	................................................................hRp........R.ht.ht.h.s......................................hhht.s.s..phh..............................p..........spl....hDlS.tuGh..tlth....sp..........thphGp..............tl............plpl....phsptsh.............................................h.........htu.pl..h...phptp........................tlGl..pF.......ths...t..t..l.th...h..............................................................	0	680	1242	1622
+7067	PF07239	OpcA		Outer membrane protein OpcA	Moxon SJ	anon	Pfam-B_17433 (release 10.0)	Family	This family consists of several Neisseria species specific OpcA outer membrane proteins. Opc (formerly called 5C) is one of the major outer membrane proteins and has been shown to play an important role in meningococcal adhesion and invasion of both epithelial and endothelial cells [1].	25.00	25.00	25.20	25.00	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.73	0.70	-5.46	2	56	2012-10-03 17:14:37	2003-09-11 11:44:44	6	1	36	2	2	42	0	202.30	53	89.45	CHANGED	QELQTANEFTVHTDLSSISSTRAFLKEKHKAAKHISVRADIPFDANQGIRLEAGFGRoKKNIINLETDENKLGKTKNVKLPTGVPENRIDLYTGYTYTQTLSDSLNFRVGAGLGhpSSKDSIKTTKHTLHSSRQSWLAKVHADLLSQLGNGWYINPWSEVKFDLNSRYKLNTGVTNLKKDINQKTNGWGFGLGANIGKKLGESASIEAGPFYKQRTYKESGEFSVTTKSGDVSLTIPKTSIREY	.....................................................sEaTV+TDlSp.o.ppA.LKEKHKstKpIuhRADhPFD.hppGhRhEsuauRsKKshhslpp.spp.hG........psV.EpRhDlYsGYTYTQsLS-uhphRsGhGLGaEp.KDu.ltspKtT.l.....popRpuahsKsHADLhSpLGsGWYlNPWuEVKhDLsu+hKhNssVsslppDINtK.TpGWGhGlGANIGKpLs-SsuIEAGPFYKpRsaKcSGEF.slst.................................	0	1	1	1
+7068	PF07240	Turandot		Stress-inducible humoral factor Turandot	Moxon SJ	anon	Pfam-B_17438 (release 10.0)	Family	This family consists of several Drosophila species specific Turandot proteins. The Turandot A (TotA) gene encodes a humoral factor, which is secreted from the fat body and accumulates in the body fluids. TotA is strongly induced upon bacterial challenge, as well as by other types of stress such as high temperature, mechanical pressure, dehydration, UV irradiation, and oxidative agents. It is also up-regulated during metamorphosis and at high age. Flies that over-express TotA show prolonged survival and retain normal activity at otherwise lethal temperatures. Although TotA is only induced by severe stress, it responds to a much wider range of stimuli than heat shock genes such as hsp70 or immune genes such as Cecropin A1 [1].	20.70	20.70	24.50	52.70	20.60	17.90	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.88	0.72	-4.49	9	49	2009-01-15 18:05:59	2003-09-11 11:50:11	6	1	7	0	12	57	0	82.40	32	60.05	CHANGED	susDcsoKh+sh.pLlshYc+assph.LsspcRtphcchlpcacscp....hVDGVPuQGGhhstlhttll..hu.tlssuhhcthhE	...usD-sTKhcsl.cLlshYc+assph.Lssp-+ppl-chlpcaccpp....lVDGVPuQGGhhtplltphls.suptlssshhp.....................	0	8	8	12
+7070	PF07242	DUF1430		Protein of unknown function (DUF1430)	Vella Briffa B	anon	Pfam-B_17033 (release 10.0)	Family	This family represents the C-terminus (approximately 120 residues) of a number of hypothetical bacterial proteins of unknown function. These are possibly membrane proteins involved in immunity.	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.35	0.72	-3.94	19	961	2012-10-03 05:18:07	2003-09-11 13:29:22	6	2	507	0	38	409	3	99.70	36	16.07	CHANGED	Ilhlhhs..lhlhhphshhYFcpa++clhIK+laGhshhcpappalhhplhshlhshshhhlhpp..s.llhhhslllhlhphllhlhhp.+hpp+thhpll.KG	.................Ilsluou..ILLF.ohNhLYFEpFRRplhIKRluGhphhEhHtp..YL...luQhulh.lh.Ghllohllp+......-hh.luhLslhlFhhpuLLpLhhQ.pKEp+hshtllKG.................	0	13	21	31
+7071	PF07243	Phlebovirus_G1		Phlebovirus glycoprotein G1	Moxon SJ	anon	Pfam-B_17508 (release 10.0)	Family	This family consists of several Phlebovirus glycoprotein G1 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi [1].	25.00	25.00	44.80	44.00	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	526	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-13.14	0.70	-6.35	4	348	2009-01-15 18:05:59	2003-09-11 13:41:35	6	4	57	0	0	288	0	338.10	54	53.03	CHANGED	sHlpNRPGpGtat..hssp-DusC+.lsYGssCpuFDahLchs+aPFFpSahcH+ohLEAhtDsI.Itppss.oCsl..sot+sstCh+EtthhKt+CPsshsusaYlsspGclssVKCcpNhELoEDCs.CRphptpu......pKh.hPLQDhhCQpsps-hossKphhKGlCcIGlhshKcCc.phoosaEsVsFhlhKs+tKlYl-phcl+sc-slpp-sFlCY....th.ss-ssuss+ttLKpVcVspCKtVssSpsKhCoGDpsFCS+YsCpsphs-saC.hAsGSGslplplsGVWlpPhClGYERVlVcREh.ts..s.pcsCDTCloEChcptllV+STGFcIouAVACSHGuChSspQpPSTplhlPYPGhupSlGGDIGlHhoH-ssssSsHhVsHCPP+DsChsHuCllCsHGllNYQCHTsLSAhllshllh.hlhhhLhllppsLhll+lhPthLlsPlsWlshFhtWhh+ph+h+stssIsRlNccIGWh-puths.pcscchp++..tPhsR.psshLhlL.LlhossS	.............................................................................................................................................................................MASVKCP.P.K.YELTEDCNFCRQMTGAS.....LKKGSYPLQDLFCQSSEDDGSKLKTKMKGVCEVGVQALKKCDGQLSTAHEVVPFAVFKNSKKVYLDKLDLKTEENLLPDSFVCFEHKGQYKGT..M.D..S..GQTKRELKSFDISQCPKIGGHGSKKCTGDAAFCSAYECT....AQ.spshC.hhptsu.l.lphsGhhhhPhChGapchhsphp..t...pp.t.CssChhcC..ttlhlhohs.cl..AssCupt.C......................................................................................................................................................................................................................................	0	0	0	0
+7072	PF07244	Surf_Ag_VNR		Surface antigen variable number repeat	Yeats C, Fenech M	anon	Yeats C	Family	This family is found primarily in bacterial surface antigens, normally as variable number repeats at the N-terminus. The C-terminus of these proteins is normally represented by Pfam:PF01103. The alignment centres on a -GY- or -GF- motif. Some members of this family are found in the mitochondria. It is predicted to have a mixed alpha/beta secondary structure.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.81	0.72	-3.56	395	14038	2012-10-01 23:48:22	2003-09-11 13:48:50	10	36	2604	32	3439	10633	6054	78.00	20	34.08	CHANGED	hhlp..plph.p.G.........t..........p.thpsp...tlp....p..h.....p.....h....ptG.............shasppplpp....shppLp.......spGa.....hspV.......ps..psp....pt....tt.......h..slshplpEs	................................................hlpplph..p..G..........s........................p.th.psp........hlp.........p..l....t..............l...........ctG......................................................chasp.pp.lsp...........shc.pLp..........spGa..............h.s.sV..........ps....php.......s..............sp............l..slhhplpEt..................................	0	1092	2111	2811
+7073	PF07245	Phlebovirus_G2		Phlebovirus glycoprotein G2	Moxon SJ	anon	Pfam-B_17508 (release 10.0)	Family	This family consists of several Phlebovirus glycoprotein G2 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in the Golgi [1].	25.00	25.00	27.30	25.60	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.62	0.70	-6.23	4	259	2009-01-15 18:05:59	2003-09-11 13:53:40	6	21	64	0	61	265	0	373.20	38	33.86	CHANGED	CS-pllAsSKlspCsscGSsThCplSGTlhl+AGsIGuEoClhLKGsc-sppKFloIKTISSELsCREGpSaWTo.YsPpCLSSRRCHLVGEChus+C.pW+sspsStEFoGlscsplMpEN+CFEQCGGlGCGCFNVNPSCLaVHuhL+Ss++EAl+VFsClDWsHRlsLElTsasGchphVsLsu.oTpFhsWGSloLuLDuEGIoGTNSaSFlcSuuGuFAllDEsaS..PRcGFLGEIRCsSEuuAloAHcSClhAPsLIcYKPMhDplECTTsLIDPFAlF.RGSLPQTRNGpTFouSh-K+TVQAFTsGtV+AsloLshDsaEVsF.sptssCsAoFlNlTGCYSCstGARVClplpustssshascscDpSlsllhslpssspD.CpVLHFopP.Vc.-hhYSCsup.+shlIKGTLlAhsPaDDR++pGGsSsVVNPKsGsWsh.sWhSGLhsWLGGPLKThLhILGalALuIlhhllllllstpuVsph...slKKKs	.........................................................................CSE.l...AsS+lhpCsp.....pGsp..s..pCphoGosll+hGslGuEuCL.h.lKG....p....-s.p.pp..h......lpIK.TlSSE..L..sC+EGpSaWTspasspChSoRRC+hh...G-Chss+C.papsNphS.sEashhtcs.pshttstCh-pCGGhuC.G.CFsssPSCLFh+tahpssp...tphhclapC.sW..s.....phh..l..p..l...T......s.....t...p...ht.......h.....h.....h..s.ssp......hphs.o.l...s.l........s....t.l.....s.s.....ssh.s...hp................t.........th.....ulhsts.s........sh.GhlG.ElpCsocpssh..p..sCh.hs.slhthp..hsth...C...s...phhs..shh...h.s..t..lP.th..h..ss..h.p..attphtppsh...psh.s.st.lpsthpl..h.c.s.hpl.h.t...pCput.h.h.ploGCYSC.tGup...h...phphpu..pt..p..s...h...h..pt.ttph.........s..ssps.........h.h..s..s.....lp.ph.hsCs.t...p..h.lpG.L...h..t................t.....p.................s..t.htth...h..t...........h.h....lh...h.hhhh..................................................................................................................................	0	3	13	61
+7074	PF07246	Phlebovirus_NSM		Phlebovirus nonstructural protein NS-M	Moxon SJ	anon	Pfam-B_17508 (release 10.0)	Family	This family consists of several Phlebovirus nonstructural NS-M proteins which represent the N-terminal region of the M polyprotein precursor. The function of this family is unknown.	23.90	23.90	24.00	30.70	22.50	23.80	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.72	0.70	-5.23	3	151	2009-01-15 18:05:59	2003-09-11 13:59:48	6	2	22	0	0	160	1	102.90	40	14.73	CHANGED	IasLLsVL.TlulLVsuslpLcophSSSRs-TCFSsoTsPEhIEtYWth-StKc-.MPph-L+CRhs.-uDhKhhop.shIStI+EVpTSssEL+hSCGsps+SLGtlITsDGLNN.hhGshIIsCsTs.a.psIssG.t.sRl..DapplKppA...-EK-thIph.+TK-sE-.....D.+sQlhhpEIpQlKNplpK+RN-....lhRGQE+RDAKplscEoMARlusL+pc.h.LT..........DElpphKsphp.hRp+.h..pTVlPA.........LhosALLS..suPlsA	..............................................................................................................................................................................................................................................................................................................................................................................................................................hpshss......................................	0	0	0	0
+7075	PF07247	AATase		Alcohol acetyltransferase	Vella Briffa B	anon	Pfam-B_17349 (release 10.0)	Family	This family contains a number of alcohol acetyltransferase (EC:2.3.1.84) enzymes approximately 500 residues long found in both bacteria and metazoa. These catalyse the esterification of isoamyl alcohol by acetyl coenzyme A [1].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.56	0.70	-5.95	9	349	2012-10-02 12:01:53	2003-09-11 14:19:53	7	8	173	0	229	370	1	388.30	14	80.46	CHANGED	+hGhlEpYahtcstpphaoNFsVhuphNptls+p...LshALRplll+pshLspslh.th..p..thhsussahspP.........l.cplchsDVl.................catc.s.phsshh.phlsphhhshssss.PhW+Llllsstpst.....ppal.alssHshhDGlSuspFacDLhcpLsphcsssh..................-hlhcY.....scDhs....KLPtPIpptl-h..hsshhslshhhhss.lhpth.hpch..............ppshhsshsssptutpshp.hlphossclppI+spsKpp...csTlTsalpusahluLtch.h.......shhp.sphshchtlPhssR+alP-ctE...papYGshVuuspa..hIpshshppsp.pph.......WsLsphappplspuhpstcphpshGs...ph.llchhNlcchhpsch.ppp..RusshlSNlGhhs......pssptaplpDhhFuQssu.ht.sFsLsVlSTssGGhNhslohhccs.pppsp.......ccFhshhcphl	.............................................................................................................................................................................................................h..sht.hh.p....h................................................l....lphpt...hl.....................................t........t............t.........h...p...h...p...t...h.........h.....h.................p....P.W+.lhl..l...pt..............................h.l..hhhpHshhDGhSuhhFacshh.ptLp.t.h.pt............................p......lhp...................ts...................l....P.....s..hp.hhth...........hh........h.............hh...p.....h......h...htp........................................sh...h....tht..h..t......s...p..s.hhh.h..l...pls..s...p..p..hpplhpts+pp....tsTlTuhlpuhhhhultp...........hhtt.tt.h.t...hpht....h.shsh.Rpa..h..sp.t............t...................h.s.s..hl........s..t.....p......h............h......th.p..h..................pth.............................Wphspphp.p.plp..p..t.h.p.p..t.......t....hh..............l.....h.p..h.h..s..h............t.hh..t.ph.....t.p.......ttsh.lSNl.Ghhp.................................ttt.h............ltph.hFsps.......ht...h..hshh.s.h..t.h.h.hs................................h............................................................................................................................................................................	0	50	118	198
+7076	PF07248	DUF1431		Protein of unknown function (DUF1431)	Vella Briffa B	anon	Pfam-B_17470 (release 10.0)	Family	This family contains a number of Drosophila melanogaster proteins of unknown function. These contain several conserved cysteine residues.	21.10	21.10	21.20	21.20	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.00	0.71	-11.84	0.71	-4.25	17	156	2009-01-15 18:05:59	2003-09-11 14:24:22	7	2	17	0	90	156	0	139.20	29	58.24	CHANGED	Cpps..Cst.h..phDhpaY+PSDKttRcYQpTWsEC...s.hhhK.K+lCt.t.hhsPphtRRptptpstss..t...............s.h.ph....tt.CP+lphP.sC+suRtPPpCchs.Rt.osC.pKhps.YPSFSECp+ttlsphs..PhECpCLctsshCphapth++p	...............................................C.....h..phD.haY+sSDKttRcYQpTWsEC....s.hh..h+.KchCs.tthh....s.h...RRp..t..p.h.tss.....................t....h.........pt.Cs.+.hths.sC+su.+hsspCphh.+t.sp.C.pKhts.aPSFSECp+..h....h...shECtChp.hs.shCphht.ht.........................................	0	15	16	57
+7077	PF07249	Cerato-platanin		Cerato-platanin	Vella Briffa B	anon	Pfam-B_17594 (release 10.0)	Family	This family contains a number of fungal cerato-platanin phytotoxic proteins approximately 150 residues long. Cerato-platanin contains four cysteine residues that form two disulphide bonds [1].	21.30	21.30	21.50	21.30	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.53	0.71	-4.10	5	199	2012-10-01 21:39:58	2003-09-11 16:37:23	7	4	96	2	128	194	0	112.80	36	70.21	CHANGED	lSVSYDsGYDDAsRSMssVSCSDGsNGLlTKY.WPTQGuVPGFPRIGGlsuIAGWNSPsCGTCaKlTY.NGNTIaVlAIDuAuuGFNIupoAMscLTNGpAspLGRVD.AsYpQVusSsC..Gl	......................................ploYDssYD.su...st.SlssVuCScGsNGL..hs+h..apT.........GplPsF.......PhIGGs....slsGW.N..S.s.s..CG.s..CacloY.....s......G.....c..oIhllAlDp.........u.s.u.....G...FNl...uhsAhstL.TsG.p.....A.....s.....p.....h.....Gp..ls......sshppVssopCu............................	0	40	73	109
+7078	PF07250	Glyoxal_oxid_N		Glyoxal oxidase N-terminus	Vella Briffa B	anon	Pfam-B_17519 (release 10.0)	Family	This family represents the N-terminus (approximately 300 residues) of a number of plant and fungal glyoxal oxidase enzymes. Glyoxal oxidase catalyses the oxidation of aldehydes to carboxylic acids, coupled with reduction of dioxygen to hydrogen peroxide. It is an essential component of the extracellular lignin degradation pathways of the wood-rot fungus Phanerochaete chrysosporium [1].	24.30	24.30	24.30	24.30	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.93	0.70	-5.30	8	414	2009-09-11 10:08:30	2003-09-11 16:40:41	6	32	162	0	296	444	14	222.20	27	32.88	CHANGED	MHhtLl.+ss+VlhaDRTsaGsSpluLPsGt.CR.ssPp.DtstKhDC.oAHSlLaDVsTNslRPLslpTDTWCSSGulpssGoLV.......QTGG.t-...G-+slRhFoPCs....ssoCDWlEhsss..Lus+RWYuTNpILPDG+hIllGGRc..........sFNYEFaPc.sp.sspsssl.FLt-TcD.spENNLYPFVaLLPD...GNLFIFANsRSIlaDacpN..pVVKEaPpIPGG.sR..NYPSoGSSlLLPL.....hpssslssEVLVCGG	.............................................................................................................................................hh.u..as........s.s.th.c....s...l.t....l...h....o.ssaCuuG.s.hl.s.s..G.phl............................psG....G.......t.s......................Gt.p.s.l...R.h....hs.P..ss........t.ss..s.WhE.sst............Lpps..RWYsosthLs.D..G.p.l.lllG.....Gpp.................................sss..h.E.hh.Pp........t......sst...s..hth....h..ht...h....pc......st..........tNLYPalalLPs...GplF.....lhus....p....p.uhlh.D.tst....ph.hpp..hP...s...lP.......u......s...s......R...sYP.sGuushLPl.............s..t.....splllCGG.............................................................	0	131	220	266
+7080	PF07252	DUF1433		Protein of unknown function (DUF1433)	Vella Briffa B	anon	Pfam-B_17690 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 100 residues in length.	25.70	25.70	25.90	25.90	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.17	0.72	-3.78	17	1163	2009-01-15 18:05:59	2003-09-11 17:04:15	6	2	257	1	16	477	0	88.50	47	68.38	CHANGED	aacpQcpRIslYlKYNlpc...hKSlpFTphcpoPMGs.hIcGYINssKchcFpAhIustcs...pFpsshshstE.Ls+LlK..c..tK...SVsEI..Kc	...................YaccQpcRIsLYhK.a.Nhpc...hKol..+F.T.s.h.c.puPMGu.hsIcGYINcN.K.c.cFsAahsspcN..aQF.ss.sl.h.hocc..LucLlK...cp...hK....Ss--I.Kcc...............................	0	5	6	13
+7081	PF07253	Gypsy		Gypsy protein	Moxon SJ	anon	Pfam-B_17444 (release 10.0)	Family	This family consists of several Gypsy/Env proteins from Drosophila and Ceratitis fruit fly species. Gypsy is an endogenous retrovirus of Drosophila melanogaster. Phylogenetic studies suggest that occasional horizontal transfer events of gypsy occur between Drosophila species.  Gypsy possesses infective properties associated with the products of the envelope gene that might be at the origin of these interspecies transfers [1]. This family contains many members with full-length matches; however, it also includes a number of very short sequences and short matches of sequences with other unrelated domains on them, which cannot be excluded. These matches may represent remnants of once-functional genes.	20.30	20.30	20.70	20.50	19.20	20.00	hmmbuild  -o /dev/null HMM SEED	472	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.66	0.70	-6.17	4	136	2009-11-18 11:40:33	2003-09-12 09:50:16	6	8	26	0	22	137	1	259.90	27	82.28	CHANGED	s+ITDaS+ANYIPVhDGcVLVa-ppshl+HSuNlSEYtshID.ET-plp-SF.PpSHM+KLLpVDssHLRshLslLplHH..RlARSLDFLGTALKVVAGTPDssDh.+I+hTEspLV-uNspQIhINocTQpQIN+LTDTINKllpupKuD.lDTsHLaEsL.sRNRllspEIQNLhLTITLAKhsIVNPsILDHsDLcollcp....sTPI...hpllEsucI+VLQSpNhIHhlItaP+lphpC.pKVslhsVsHpcTlLRLc-sslAECc+-hauVps.CohTs+sTFCcpu.....pp-oCsppLHAGssApCH.sQsSHL+tIp.VD-GlllIN-tsApVpsDsssclhlpGTaLITF.pcSATINtopFhNhcpslsKtPGllpSPlLNI.u+c.lLSlPhLHRhs.pNLhpI+shpc-Vsutt.sphhhshGsllssGlhhuhslhLshRt++uotphp+slcphs.sE-GppLctGlVpN	....................................................................................................................................................................................................................................................................................................................................................................................................................htu..upCp..h..tp....h..lptu.hh.hhst..h.h...tt..p..ltGoallpa.ppph.lstp.a.s...............................sh..lp..p.t.................................................................................................................................	0	0	0	14
+7082	PF07254	DUF1434		Protein of unknown function (DUF1434)	Moxon SJ	anon	Pfam-B_17586 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 135 residues in length. Members of this family all appear to be Enterobacterial proteins. The function of this family is unknown.	20.70	20.70	21.10	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.78	0.71	-4.34	9	557	2009-01-15 18:05:59	2003-09-12 09:52:45	7	2	555	0	49	179	2	124.40	72	96.04	CHANGED	MsLWpsDLRVSWRoQhhSLLlHGllshllLLsPWP...u.YsslWLlLLoLVVF-ClRSQRRIpupQGElpLLsDspLpWptpEWpIl+pPWhl+.GhlLpLppsss.p+Rp+LWLAADSMspsEWRcLRpLLL....pp	..................MVLWQSDLRVSWRAQWlSLLIH.G.L.V.AA.V..I..LLMPW.P....LS..YT..PLWM.l....L...LSLVVFD....CVRSQ.R.R....I.N..uRQGEI+LLMD...GRLRW..Q.G...QE.......WoIVK...sPW.hlKSGMhLRLR.s-u.G.........+.........R......Q....HLWLAADSMDEAEWR-LRRILLQQ........	2	4	14	30
+7083	PF07255	Benyvirus_14KDa		Benyvirus 14KDa protein	Moxon SJ	anon	Pfam-B_17595 (release 10.0)	Family	This family consists of several Benyvirus specific 14KDa proteins of around 125 residues in length. Members of this family contain 9 conserved cysteine residues. The function of this family is unknown.	29.30	29.30	30.10	213.00	27.00	29.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.80	0.71	-4.25	2	7	2009-01-15 18:05:59	2003-09-12 09:58:37	6	1	3	0	0	7	0	122.60	80	96.84	CHANGED	MthssSlsVaVtcsIT......psschFSlKhupWpLFTstVaVpYRths-cEpslKDssRLHFphpCVpCspKlphKtpN+sH.calppGalRhsRNFSIlGsCucC...h-Shs.tDEhcpslV	MGMVDSLCVFVGRVITEGSESVEGVERFSIKFSEWKLFTTAVYVEYRQLGEKECSLKDVGRLHFNMSCVKCCpKLKCKKQNKNHSKHVQNGYLRKVRNFSILGVCGDC...CESFTLADEKHHVIV	0	0	0	0
+7084	PF07256	DUF1435		Protein of unknown function (DUF1435)	Moxon SJ	anon	Pfam-B_17631 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.	22.10	22.10	22.40	24.10	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.58	0.72	-4.00	7	529	2009-01-15 18:05:59	2003-09-12 10:16:13	7	1	520	0	37	208	0	77.10	68	86.83	CHANGED	MLpRsLuSGWGVLLPGsllssLuahsLSh-thRlLIVluhLhTssMLYHppLRHalLLPSClALluGlhLhhhshp.G	.....MLQRTLGSG.WGVLLPGlLIsGLhaADLSsDQWRIlIlhGLlLTslMLYHKQLRHYlLLPSCLALIuGlMLhlMNlNQG......	0	1	9	21
+7086	PF07258	HCaRG		HCaRG protein	Moxon SJ	anon	Pfam-B_17801 (release 10.0)	Family	This family consists of several mammalian HCaRG(hypertension-related, calcium-regulated gene) proteins. HCaRG is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. HCaRG is a nuclear protein potentially involved in the control of cell proliferation [1]. 	20.70	20.70	20.80	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.74	0.71	-4.73	74	1021	2009-01-15 18:05:59	2003-09-12 10:30:12	9	19	136	1	629	1011	16	157.10	16	82.18	CHANGED	lshlsplspp.t.......htplhp....hshptlpttpstp................................htphtp.ht.....hstp..................phpt.lhpulthllppuspt...shsppphpppL.ppht......lsp-.ptpslsphatppppplpptltppsht.hsp.Lpsl..........pWRlclpluSsph..pc...htpPhhhl.pLplpss.......tp.pslshEhshsplppllpplcphppphpsh	.................................................................................h........s............h..hhp.hhp..l.h..t.t.t.p.................................h..thtt..ht.......h.s..t......................phpt.hltshth.lhpp..s.spt........shst..pphp.ppL..t.p..ht....................h.sp..-.tt.......phl.s.p.h.at...........p.p.p.pp.lp.pt.h....h.p..pt.......ht...hsp..ltsh..........pW..+ls.hp.h.u.o.sph...pp...........htpPhhhl.pLplpps.......................tp.p.th.thphsh..tphpphhtplpphtt.hpt..........................................................	0	238	284	439
+7087	PF07259	ProSAAS		ProSAAS precursor	Moxon SJ	anon	Pfam-B_17813 (release 10.0)	Family	This family consists of several mammalian proSAAS precursor proteins. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed among neurons. ProSAAS is thought to be an endogenous inhibitor of prohormone convertase 1 [1] may function as a neuropeptide [2]. N-terminal fragments of proSAAS in intracellular Pick Bodies (PBs) may cause a functional disturbance of neurons in Pick's disease [3].	21.70	21.70	21.80	82.20	20.90	21.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.28	0.71	-4.76	2	25	2009-01-15 18:05:59	2003-09-12 11:08:19	7	2	17	0	12	20	0	165.00	77	74.38	CHANGED	MAGSPLLCGPRAGGVGILVLLLLGLLRLPPTLSARPVKEPRSLSAtSAPLVETSTPLRLRRAVPRGEAAGAV.thu............tRututsttucDppARVL.tphLR.....uWtS.........PRsp..PLAPDDDPDAPAAQLARALLRARLDPAALuAQLVPAPAsAPRPRPPVYDDGPphP..cctGscp.Dh	......MAGSPLLtGPRAGGVGLLVLLLLGLhR.PPsLsARPVKEPRuLSAASsPLAETusPRRFRRAVPRGEA.AGAVQELARALAHLLEAERQERARAEAQEAEDQQARVL.AQLLR......sWGu.........PRsSDPsLu..DDDPDAPAAQLARALL.RARLDPAALAAQLVPAP..A..A..Ah..R...PRPPVYDDGPsGPDsE-AGDETPDV..	0	1	1	2
+7088	PF07260	ANKH		Progressive ankylosis protein (ANKH)	Moxon SJ	anon	Pfam-B_17517 (release 10.0)	Family	This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralisation and bone resorption [1]. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterised by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones [2].	20.70	20.70	21.10	20.70	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.25	0.70	-5.45	2	82	2009-01-15 18:05:59	2003-09-12 11:17:30	6	2	49	0	46	68	9	277.50	65	67.24	CHANGED	Mhch.S.TsYWPLIRFLlPLuITNIAIDFGEQALNRGIAuVKEDtlEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK+-t.KAlLCMsVAGlIAhlhHsLIAYoDLGYYIINKLHHVD-SVGuKTRKAFLYLAhFPhhDAMAWhHAGILLKHKYShLVGsASISDVlAQlVFVAILLpSpLEChEPLLIPILuLYhGALVRhTslsLGYYpNlHDhhPESous-.GGDATIKKMLSFWWPLALILATQRISRPIVNLFVSRDLtGSoAuTEu.................hT-hpuh.PhF..................TtIcphphsshuLSLoL.....Wo	...........................llpFhlPLuloslshshucQALNRGIAuVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNS.K..RD.RsKAVLCM.V..VAGslAuVhHsLI.AYoDLGYYIINKLH.HVD-SVGsKTR+AFLYLAAFPhhDAMAWhHAGILL.KH.KYShLVGsASISDVlAQ.....lVFV.AILLHSpL.......ECtEPLLIPI..LSLYMGALVRhThls.L..GYYpNIHDhIP-pSGsEhGGDATI+KMLSFWWPLALILATQRISRPIVNLFVSRDLtGSSAATEAVAl.LTATYPVGHMPYGWLTElRAVYPAFDKNNPSNKlhsssssVTtsHIK+FTFsChALSLoLCFlhFWT.............................................................................	1	12	17	25
+7089	PF07261	DnaB_2		Replication initiation and membrane attachment	Moxon SJ	anon	Pfam-B_17543 (release 10.0)	Family	This family consists of several bacterial replication initiation and membrane attachment (DnaB) proteins, as well as DnaD which is a component of the PriA primosome.  The PriA primosome functions to recruit the replication fork helicase onto the DNA [2]. The DnaB protein is essential for both replication initiation and membrane attachment of the origin region of the chromosome and plasmid pUB110 in Bacillus subtilis. It is known that there are two different classes (DnaBI and DnaBII) in the DnaB mutants; DnaBI is essential for both chromosome and pUB110 replication, whereas DnaBII is necessary only for chromosome replication [1]. DnaD has been merged into this family. This family also includes Ftn6, a cyanobacterial-specific divisome component possibly playing a role at the interface between DNA replication and cell division [3]. Ftn6 possesses a conserved domain localised within the N-terminus of the proteins. This domain, named FND, exhibits sequence and structure similarities with the DnaD-like domains Pfam:PF04271 now merged into Pfam:PF07261.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.39	0.72	-4.38	110	3374	2010-01-07 15:44:22	2003-09-12 11:29:14	6	17	1459	3	391	2143	21	75.80	23	26.80	CHANGED	lhphhcpp..hup.LSsh-hcplppalpp...phss-llphAlcpAl.tp..schs..h+YlcpILtsWpcpslpTlcpspphtcp	.........................hphhppp....ht..t...los.h-h....cplpphlpp........phss-....llphAlchuh...p.......schs.........hpYlp.p.ILpsWpc.p.s..lpThcpspth...t...............	2	151	271	328
+7090	PF07262	DUF1436		Protein of unknown function (DUF1436)	Moxon SJ	anon	Pfam-B_17809 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 160 residues in length. The function of this family is unknown.	25.00	25.00	25.10	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.63	0.71	-4.75	9	103	2009-09-11 13:43:21	2003-09-12 11:34:26	6	1	77	1	17	82	1	145.10	44	86.54	CHANGED	pch.sthphTscFlSlpoYSGhshhshDshtssplLsPDlsspslGcsILpALScSRhl..s.--.t.sFhDhEptp.pYcsWlpplMtpYuY+o++uLFKsMh.suIpllNs.IpIpPo+H-KLEuWosst.psu-hVhl..slDsSPEElGuuL+.AFp+C	........................h.s.h.hstchh.lpohuthshhs.D..hsspl...Ls.DsDspsLGpslLQALusSRTh............cs.Epp.-FFcpEch+p.cYc-WlspLhsphGYKT+RALFKNMhsssIh..lpNuslcIoPS+HsKLEAWsuh....-uDsVlL..slD..sSPEEIGAuL+LALSRC....	0	3	8	12
+7091	PF07263	DMP1		Dentin matrix protein 1 (DMP1)	Moxon SJ	anon	Pfam-B_17812 (release 10.0)	Family	This family consists of several mammalian dentin matrix protein 1 (DMP1) sequences. The dentin matrix acidic phosphoprotein 1 (DMP1) gene has been mapped to human chromosome 4q21 [1]. DMP1 is a bone and teeth specific protein initially identified from mineralised dentin.  DMP1 is primarily localised in the nuclear compartment of undifferentiated osteoblasts. In the nucleus, DMP1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the early phase of osteoblast maturation, Ca(2+) surges into the nucleus from the cytoplasm, triggering the phosphorylation of DMP1 by a nuclear isoform of casein kinase II. This phosphorylated DMP1 is then exported out into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP1 is a unique molecule that initiates osteoblast differentiation by transcription in the nucleus and orchestrates mineralised matrix formation extracellularly, at later stages of osteoblast maturation [2]. The DMP1 gene has been found to be ectopically expressed in lung cancer although the reason for this is unknown [3].	19.20	19.20	19.70	19.60	18.60	19.00	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.11	0.70	-5.77	4	486	2009-01-15 18:05:59	2003-09-12 11:45:14	6	2	401	0	21	468	0	337.60	57	98.59	CHANGED	MKToILLMFLWGLSCALPVARYQNTEScSSEEhKGcLAQoPsPPLESSESSEESKlSSEEQANEDPSDSTESEEtLGhDcpQY.aRPAGGLS+SsGptG-DKDDDED-SGDDTFGDDDuGPGPEEtp.GGsSRLsSDEDSsDTTQSpEDSsPQG-sSAQDTTSESR-LDsEDEsDSRPEGGDSTtDSESEEpWVGGGSEGESSHGDGSEFDDEGMQSDDPtohRSERGNSRhSoAGlKS+ESKGcDcEpASTQDSs-SpultasSRKhFRKSRlSEEDsRGEL-DsNoh.EVpSDSTEs.....stLoQS+EcS+uESQp-ScENpS.E-SQcVQDPSSESSQEssLPSQENSSESQEEsluESRGDNPDNsTSau.EDQEDS-SSEEDSLcp.SsSESpSpEEQADSESpESLp.SEESPESsE-pNSSSQE.GLQupSuSsESpSQ......-ShSEEDD.SDSQDSSRSKE-SNSTESsSSSEE-uQsKNhElESRKLTVDAYHNKPIGDQDDNDCQDGY	.................................................................................................................................................................tt.oRhts.........s-DSuDsTpSp...E-Sssp.E-......us.......p....D..s......s..S......-......S+sh.-pE....................S-SEEaWVGGGS.E.G.-.SS.HG.D..............GSEF...DD..EGMQSDDPD....ol+S..ERupSRMs..S..Au.l..+SKE...S..psp.s.c.c.p.ussQD.S.s-.SQSV-psuR.KhFRKSRIS..t..EDDpu-hssSsoh..E.spSDSTEso............ppus.u.....Q...S+Es.SKS..-SQEDSp..E.s.QSQED..SQs.pDs...SSES.S....QEsDh.PSQE.....sS..SESQE..E..lh.ucSRGDNP..D.s...s...o.s...p...u......ED.Q-D..S.-...SS...EEDSLspsSsS.ESpScEEQAD.SE...SsES..L.p.SEES.ESoE..-ENSS.SQE.GLQSpSuS.s.E..SQ..S...........p......................p.....S.S.E....E.-..s..ps......Q-...s.s....c...S..........ts....S.sp-......p...-h-s..................................	0	1	1	5
+7092	PF07264	EI24		Etoposide-induced protein 2.4 (EI24)	Vella Briffa B	anon	Pfam-B_17540 (release 10.0)	Family	This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53 [1]. It has been suggested to play an important role in negative cell growth control [2].	31.50	31.50	31.50	31.50	31.40	31.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.81	0.70	-4.91	191	1863	2009-01-15 18:05:59	2003-09-12 11:56:43	6	6	1751	2	510	1310	173	215.70	27	82.70	CHANGED	suhttulp...tht................psphhthllhslhlsll....lhsshhhh..hhthltshh................................hshl.sh...............................hhhthhhhlhhhll...hhhl...hsslsshlsuhF.......hshluctl................................ptc.phsp.......hsthtshspul...hpplttlhhhlhhh..lhsl..hL...hh.lP..sl...s.hh..llahhlsu.....................ahhuh-ahshs.........h......shpctc.thhcpptsthhuhGhhhsh..............hhhlPllNllh.Pl	.............................................................................................................................................................uhhhhhpshthh...............pPtltph.lllPlllsll....Lhsu....hhah....hh.stlssa...ls.slhshhs.........................sWlphh...........................allh.lsslshlll..........hsah...hss..lushI.uusF.......ss.hlAEpl.........p.............................................sst..phss........shhshhtsls...+hh...tc.ph..p.p....hhh.h.l...sts....llhl....lL....ha.lP....sl...Gthlssllaalhsu.................................ahlulp.Yt-as............hspp.........hshcch+.shl+.p.p+h.t..shtF.G.slsuL........................hshlPllNLhh.Pl................................................	0	150	292	412
+7093	PF07265	TAP35_44		Tapetum specific protein TAP35/TAP44	Moxon SJ	anon	Pfam-B_17587 (release 10.0)	Family	This family consists of several plant tapetum specific proteins. Members of this family are found in Arabidopsis thaliana, Brassica napus and Sinapis alba. Members of this family may be involved in sporopollenin formation and/or deposition [1].	25.00	25.00	163.30	163.10	18.70	17.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.68	0.71	-4.34	5	15	2009-01-15 18:05:59	2003-09-12 11:59:58	6	1	7	0	5	15	0	121.30	65	99.95	CHANGED	MSpISKVSSLCLLLLshFFLSSQPALSLRuPKhQ.SEPsS.................PEolhsDSSSsMsKI.DpssAKSMIAGFFSHKFPLpGWPF.KYPPFoM...VNPNIP..TNPS.....GAQEEoEKLPSSPSKGNKDGGNA	.MS.IS+VSSLCLLLLV.hFFLoSpPALSLRuPK.Q.SEsAS.................PQThhDDSSs.Ms+I.D..pAKSMIAGFFSHKFPlpGWPFPKYPPFoM...VNPNlP..TsPS.....GAQEESEKlPSSPSKsN+DGtNA	0	2	2	2
+7095	PF07267	Nucleo_P87		Nucleopolyhedrovirus capsid protein P87	Moxon SJ	anon	Pfam-B_17842 (release 10.0)	Family	This family consists of several Nucleopolyhedrovirus capsid protein P87 sequences. P87 is expressed late in infection and concentrated in infected cell nuclei [1].	25.00	25.00	29.20	29.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	654	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.36	0.70	-13.24	0.70	-5.84	6	50	2009-01-15 18:05:59	2003-09-12 13:14:04	6	4	38	0	0	51	0	343.30	28	61.12	CHANGED	MD-p.NSLLIA+LAGpILTRDhsAVssIhHoPE+SLsQKLDsLpshlpuhssus.s.ss......suclphNShllsQshllRapsLphAVsFL+Ruspl..slspphLspIQssLppYcsYVspsshDpsl.l-saLNpAEssYtEIR...pscIh.FlK...................phpt.t.ppscups.sspsssu.....sPh......................................+.ssphhpthtN...pouhochspplpuu...hh.hth.h.th.p.pDpchphha.....................................tsh.pps.....EhPlIsNEpDFD+hsI-QLs...DYI++Nhss.phsas.sHsS...VcDVRpFAKslWRtps................ssspTPh..........ph.oPtpTPh.h.....s-p..uhQoP..sPt............................s.ps...hph.p................s.hPspssssss.ss.p+++RRRsssL..hs.....................S-E-E..............s-.cEsDaEp-RKRRREEDKNFLRLKALELSKYAGVNERMEKIVQVT+AMQcTYDYCNCKNTIsGTPsAssFspLL+RLNTYNLuHVEMTVNFYELLYPLTLYNDESN.......RIluYIFAAuNYFQNCAKNFspMRs-FNpaGPFsQIDSMVMFVIKFNFLCDLQsFFGpIDsLPsLuQPNhplHsVLlMRDKIVKLAFNuLQYsTssKo-NRRDPKHLQRLIMLMNADFNII	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sst..satshlpplpphNLohlp.sVpFYcLL.PLshYs...s...sp...s.......pllh...aIhtussYF.NsAcNFs.hRtshps.t.htphDphshFhI+aNFLh.hRpFhspl......s.shss..N.+IhNVLhhhDplVpptasplpaph...........................t..........................	0	0	0	0
+7096	PF07268	EppA_BapA		Exported protein precursor (EppA/BapA)	Moxon SJ	anon	Pfam-B_17945 (release 10.0)	Family	This family consists of a number of exported protein precursor (EppA and BapA) sequences which seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). bapA gene sequences are quite stable but the encoded proteins do not provoke a strong immune response in most individuals. Conversely, EppA proteins are much more antigenic but are more variable in sequence. It is thought that BapA and EppA play important roles during the Borrelia burgdorferi infectious cycle [1].	24.30	24.30	24.80	25.70	24.20	24.20	hmmbuild  --amino -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.58	0.71	-4.50	7	89	2009-01-15 18:05:59	2003-09-12 13:19:13	6	2	21	0	2	84	0	119.70	57	82.41	CHANGED	sIccNYs+AKKsFSKEDasLIpKRLDNYsFpsEYsKShhFuh.APcIRGsLRKIGIKEpuVhLDALDllGYLIKsKlhtphhhl....h.sI.pLIpGhPsuIFNaL.lQLsSDKIDYsEKYG-cAR-pFcpSYpKsKIssVK	.......IccNYscsK+uFScEDFsLIppRLDNYsFc..sEY-KShhhuc.sPcIRGpLRKItIKEpuVhLDALDlltYLIK.Khhp...lhh.........sI.pLItGYPsu.....IFsYL.IQ.LsSDKIDYAEKYG-cA..Rp..pFccuYp+DKhssVK............................	0	2	2	2
+7098	PF07270	DUF1438		Protein of unknown function (DUF1438)	Moxon SJ	anon	Pfam-B_18024 (release 10.0)	Family	This family consists of several hypothetical proteins of around 170 residues in length which appear to be mouse specific. The function of this family is unknown.	25.00	25.00	115.70	50.70	21.80	16.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.06	0.71	-4.33	5	19	2009-01-15 18:05:59	2003-09-12 13:30:23	6	2	3	0	4	16	0	126.80	58	89.06	CHANGED	MhpSFsGFVKDTSDTEEHALPSAQsLPALSTRCSKSETLCFuKEpSHCSEDGWIlDWDLY.h.CVFESVDYLRSY+RLNCAMKKGTEVFQSESQR-PQVSPGDVDNspDKDTEEPDQPhPSLLREKGLELETCDGGDCPDQDPASDSsRHLG	...hp.h.uFV+soScottHALPoAQVLPA.sstCshspsLpFutE.SHC.EDGWIspWs.ash.CV.tShDYLR.hppLNsAMK+GTElFQStoQRcPph..G.h.....psstcPDQP.PuL..LRcKGL-LtTC-GGDCPDQDPuSDSsRpLG.	0	0	0	1
+7099	PF07271	Cytadhesin_P30		Cytadhesin P30/P32	Moxon SJ	anon	Pfam-B_18052 (release 10.0)	Family	This family consists of several Mycoplasma species specific Cytadhesin P32 and P30 proteins. P30 has been found to be membrane associated and localised on the tip organelle. It is thought that it is important in cytadherence and virulence [1].	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.35	0.70	-5.13	3	109	2009-01-15 18:05:59	2003-09-12 13:35:59	6	8	24	0	13	105	16	133.40	46	68.80	CHANGED	McLss.hRhKKLFllutLLhsolLFSuLIlLATul.LVpcNsoE........psLsVVLHpsED.TssIQGRsITEQPWFIPTVAGuFGFSALAIILGLAIGLPIVKRKEKRLLEEKERQEQlAEQLQRIS.-QpEQQAlE.pPstEspsQupsQPAs.sVsssP.....QPQVQ.sFGPp.QQRls..RsGFP.QPN.Mu.RPGFN....QMPPH....PGMsPN....RPGFNP.P....GMsPRPGF........PH....PsMsPNMp..RPGF.pPQP...........GtFs+PGsPhsPNMt.RPGFsPN.GMsPsPuMtsPRuGhPP	.......................................................................................................................................................................................................................................................................................................PNpMGMRPGFN.....QMPPQ.....MGGMP..PNph..hRPGF.NQMPPp.........sGM.PPRP...NF..............PNQ..M..PNMp..+PGh.pspP...........Gh.................................................st..t........................	0	3	6	12
+7100	PF07272	Orthoreo_P17		Orthoreovirus P17 protein	Moxon SJ	anon	Pfam-B_18125 (release 10.0)	Family	This family consists of several Orthoreovirus P17 proteins. P17 is specified be ORF2 of the S1 gene and represents a nonstructural protein which associate with cell membranes [1].	25.00	25.00	53.90	53.90	23.20	22.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.94	0.71	-4.40	6	41	2009-01-15 18:05:59	2003-09-12 13:42:50	6	1	25	0	0	29	0	135.80	57	98.51	CHANGED	MpthR+poFsVpcF-...FsP.hlpphhpPshoAlstsDsstYhNI-lspoHPhhssLssLLup..PssVHVpLlRRauL.SoLssICEaDCsLltlssh.h..sosspsS+lVVHaDstoQSsAAKRSRslDslhDFEhEYK.WRFus.h	MQhLRHTTFcVpRFs...FsPlslpEhAhPSFTAITusDPopYFNIELPpoHPLhSpLPsLLSp..PCcVHVpLIRRFALaSTLSSICEYDCALLhsspAIh.LssusppSplllHWDGtSQSlAAKRuRphDTllDFE+-YK.WRFsu..l..	0	0	0	0
+7101	PF07273	DUF1439		Protein of unknown function (DUF1439)	Moxon SJ	anon	Pfam-B_18280 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.	20.70	20.70	21.10	20.70	20.50	20.30	hmmbuild  --amino -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.69	0.71	-4.49	38	831	2009-01-15 18:05:59	2003-09-12 13:49:14	7	2	797	2	138	426	24	148.20	48	78.82	CHANGED	loEpElppa....Lscch.phpcphGhsGlhssplplsslslpIG.pp.ssclslsusupsplssh.hsshssplplplcutPhYDp-csAlYL+slcLlchslpspphpsslps.lhs.lhphlsphLsspPVYpLcpsc.hspulh+phspslcVcsGc	......................................IoEQEINQu.....LsK+N.NFsK.cIGl.....P....GlsDA+IsLoNLsSQIGR-E..PNKVo..LTGDAplDhsSL.FGsQcAshKLpLKAlPsFD+....EKGAIaL.....+-MEVVDsoVp..PE....KM.....QoV.....hQo.LlPYLNQu.L.+.sYFNQpPAYVL+EDsSpuEAhAKKLAKGIEVKPGc..................................	0	19	54	94
+7102	PF07274	DUF1440		Protein of unknown function (DUF1440)	Vella Briffa B	anon	Pfam-B_17831 (release 10.0)	Family	This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.	30.90	30.90	31.10	30.90	30.40	30.70	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.92	0.71	-4.17	27	965	2009-01-15 18:05:59	2003-09-12 13:51:36	7	1	896	0	73	342	0	139.50	50	77.98	CHANGED	llSuhVKhGWEs.hPPRTP...............................pRstsNPPt....thL.p.lGlssp.spssYhausp.plsasuhllHauFSlsFA..lhYs.lluchaPplphhpGssaG.lhlalshHhllhPhhthsPss.........hc.PhpEHhSEhlGHIlWhWoI-.....ll	.....................llSuhVKhGhEVshPPRoP.................................pRsthNPP.....hhL.-.LGlss...spssYTFusp.hhsaVu.lsHhhFSIVFA..lsYC.llAEhaPKlpLWQGhlhG.lllhlhhHhIhhPlhshsPsl.........a-hPatEalSElhGHlVWhWoIEll..............	0	11	30	56
+7103	PF07275	ArdA		Antirestriction protein (ArdA)	Moxon SJ	anon	Pfam-B_17857 (release 10.0)	Family	This family consists of several bacterial antirestriction (ArdA) proteins.\	      ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification [1].	21.00	21.00	21.10	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.27	0.71	-4.00	38	992	2009-01-15 18:05:59	2003-09-12 13:53:08	6	11	631	4	85	617	101	159.80	30	62.10	CHANGED	clYVAsLupYNpGpLhGpW..lssstDt--ltt.hcclhhs......tp.........................................EEaAIHDaEshs...thplsEYssl-clsclsph.l...........p-hs.-st.tth.thh....saaus.p-hsp..cslcsh.ahuphcs.p......DhApthl--ss......hptlP.pp..L...ppY..hDYEAauRD....lplssshh..hsppGhhpst	...................................................................tlYlushu+Y.N.pG..plsGtW...hohP.h...Dh..--hp...c.clsls.......-p.........................................cE..ah...Ip..Da...E.hP.........hpl.s......Ea..s.slt.clN..clhch..l..............p-ls..cthtpt.hpthl......................shhu..s...h...p-h.p...h..csltph....h.......s-s.c.s.p....................DlAphhl-..-sG.......hl.s-lP....p.s....l...psY....hDY-AYGRD....Lthsuphh..hspcGhh...h...........................	0	37	63	74
+7104	PF07276	PSGP		Apopolysialoglycoprotein (PSGP)	Moxon SJ	anon	Pfam-B_17916 (release 10.0)	Repeat	This family represents a series of 13 reside repeats found in the apopolysialoglycoprotein of Oncorhynchus mykiss (Rainbow trout) and Oncorhynchus masou (Cherry salmon). Polysialoglycoprotein (PSGP) of unfertilised eggs of rainbow trout consists of tandem repeats of a glycotridecapeptide, Asp-Asp-Ala-Thr*-Ser*-Glu-Ala-Ala-Thr*-Gly-Pro-Ser- Gly (* denotes the attachment site of a polysialoglycan chain). In response to egg activation, PSGP is discharged by exocytosis into the space between the vitelline envelope and the plasma membrane, i.e. the perivitelline space, where the 200-kDa PSGP molecules undergo rapid and dramatic depolymerisation by proteolysis into glycotridecapeptides [1].	17.30	17.30	18.20	22.10	14.70	17.00	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.96	0.74	-6.04	0.74	-3.39	3	74	2009-01-15 18:05:59	2003-09-12 14:03:55	6	3	4	0	0	72	0	13.00	96	81.03	CHANGED	DDATSEAATGPSG	DDATSEAATGPSu	0	0	0	0
+7105	PF07277	SapC		SapC	Vella Briffa B	anon	Pfam-B_17881 (release 10.0)	Family	This family contains a number of bacterial SapC proteins approximately 250 residues long. In Campylobacter fetus, SapC forms part of a paracrystalline surface layer (S-layer) that confers serum resistance [1].	25.00	25.00	35.10	34.80	19.70	17.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.20	0.70	-5.04	83	327	2009-09-11 20:32:24	2003-09-12 15:17:17	6	4	209	0	133	355	145	216.40	28	86.79	CHANGED	L.sspcHtsl+lpstps.hsaupshphlPlhssEFtpAsspaPIlFs.csspst...ahslAlhGlcpscNLFls.-GpWpus..YlPthlRRaPFhl..............tpspsssphslslDtsustl..s....ps-G..psLF.....spsGpsopaLpphhphLpphppstptTptFhptLtchsLLpshslslsh......tsupppslsGhaslsEc+LppLss-s................lhcLp+sGhLthIYspLhSLsplppL	........................Lss.pHtsl+lp..stps.htausshphlP....lhssEaspsstpaPIlFt.....csspt.........atslAlhGlpts.cN..L.Fl......s..sGpWpus..YlPshlcRaPFhl...............ts..tppsphslslD.sustl......s...........ps...cG....psLF.....tppG.psopaLpphhphLpphppshptTptFhptLtchsLLpshplslph........tsGpptplsGhaslsEc+Lpt.Lssps................lhpLpc....pGhLthlYstLhSltplppL................	0	36	85	107
+7106	PF07278	DUF1441		Protein of unknown function (DUF1441)	Moxon SJ	anon	Pfam-B_17966 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 160 residues in length. The function of this family is unknown. However, it appears to be distantly related to other HTH families so may act as a transcriptional regulator.	26.50	26.50	27.60	27.80	25.50	26.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.77	0.71	-4.57	9	388	2012-10-04 14:01:12	2003-09-12 15:26:14	6	4	271	0	19	155	8	132.20	50	88.03	CHANGED	cLNIsQlAtloGLHRQTVssRLtsls.PAsGospphKLYtLsDllsshhst.hsssssp.hDPs.....-RKAWaQSEp-RLKhE+EptpLlPssEVtppauslsKAlVQVLETlPDlLERDsuLoPstLscVQpllD-lR-plsptlh-sss-	.........................................................................LNIsQLAAloGlHRQTVsuRLpsls.sAsGptpphKLYhLsDllsthht..hP..s.ssst..tc..hDPp.....-RKAWYQSE+ERLKhEpEptQLlPso-VcppaulhsKAlVQVLETlPDhLERDpGLpsstlscVQpllD-lR-plthtlh-sss-.........................	0	1	7	12
+7107	PF07279	DUF1442		Protein of unknown function (DUF1442)	Moxon SJ	anon	Pfam-B_18012 (release 10.0)	Family	This family consists of several hypothetical Arabidopsis thaliana proteins of around 225 residues in length. The function of this family is unknown.	20.80	20.80	20.90	21.30	20.10	20.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.56	0.70	-5.24	4	79	2012-10-10 17:06:42	2003-09-12 15:28:21	6	3	17	0	57	104	0	202.80	33	86.19	CHANGED	MKLVWSPETAScAYIDTVKSCcshcssusAEhluAhAAGWNs+LIVETWScGDsIAoSVGLsVAupHTsGRHlCIVPspcScotYltAMpttsoo.shsEslV....uEpsEcsMcclpGVDFLVVD.+p+EFs.ssL+.Athus+GAVlVC+Nuhp+uhssFpWpclL.Rsp+VVRoVhLPVuuGLEIsHVuAssuGsuts....+pRWI+HlDpRSGEEHlF++	..................................................................................WSs-sA.cAYlpTlc..................s.....p.............p...h....p..............p....s..s.....s...........A...........EhlSAhAAG.NA+LlVpshup..u.........u..s...sToluLAsAA+..p...TsGRh..lCl.lPspps.hpthtpshtph.u.h.p....phsEhl...l..........G-t...scplh..tp.h.p.s.lDFllVDs+...p.c-ah..clL+....h..sc.hu..t..p.G.....A.VlVspN...u....hp..p..t.h.s.s.h..p.a.p.......tsh......pt.pph.V...+oshLPlG.pGl-ls+lusst......s.......spt..........tp.t....................p+Wlh+lDppoG-.ahh+........................	0	9	38	50
+7108	PF07280	DUF1443		Protein of unknown function (DUF1443)	Moxon SJ	anon	Pfam-B_18027 (release 10.0)	Family	This family consists of several Baculovirus proteins of around 55 residues in length. The function of this family is unknown.	25.00	25.00	56.40	56.20	22.20	19.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.00	0.72	-4.39	23	52	2009-01-15 18:05:59	2003-09-12 15:30:27	6	2	52	0	0	46	0	43.00	38	74.87	CHANGED	llllllFllslhlLhhL+LN+tQhpchLaYQYpYIPcsLlshV	.....hhllllFlhslhhLhhL+lN+tplpchLaYQYpYIPcsLlshV	0	0	0	0
+7109	PF07281	INSIG		Insulin-induced protein (INSIG)	Vella Briffa B	anon	Pfam-B_17905 (release 10.0)	Family	This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations [1,2].	25.20	25.20	25.50	25.30	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.75	0.71	-11.36	0.71	-4.97	9	298	2009-01-15 18:05:59	2003-09-12 15:33:33	7	4	190	0	172	256	0	182.60	36	62.95	CHANGED	psl+uslLFuFGVlaullshpL.......+cNahlhPVcLcsp+a.suW.h.uhaGhuusslG.lhPhlDoa..hGcs.................cchshpWsuVsRsVuAFVGIuaAh++LsapSoTQuSlTLAhssslLWYLhDRo+sGFhLSTlluluGssllhsLts.................ssh...hGlhphhoQ-.hhVRsWlsulLFsAsVsFGNIGRQLA	.....................................................................h...pshlLF.h.GhhhuhllphL..................ppp.h..h.l.....h.s..........c....l.....s...h...h...ss..sW.........h.h...s.......h..h...G..s..u..usllGhLhPhlDph....hs-s.............................................................pp.h....pppWsuV.hRslusF.....V......GIsaA....t.........Kl.......s.........ass..s....l...QlS........LTLAhLslsL...WahFDR.S+o....GhhLu.lsl.uhlusl..hh.hls....................................................................tu.lh.phso..-h.lhlt...sWlsslhFsuslshGNIGRpLA..........................................................	0	35	71	119
+7110	PF07282	OrfB_Zn_ribbon	Transposase_35;	Putative transposase DNA-binding domain	Bateman A	anon	Pfam-B_4755 (release 10.0)	Family	This putative domain is found at the C-terminus of a large number of transposase proteins.  This domain contains four conserved cysteines suggestive of a zinc binding domain.  Given the need for transposases to bind DNA as well as the large number of DNA-binding zinc fingers we hypothesise this domain is DNA-binding.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.25	0.72	-4.32	72	6607	2012-10-03 10:42:43	2003-09-12 16:00:36	6	25	1414	0	1912	6323	252	69.10	32	19.70	CHANGED	atphtphlcYKAphh.GhplhhV...ssta.TSppCstCGphtpp.........hss+hapCsp..CGhp.hcRDhNAuhNIhpc	.....................ahphpphLpYKsp........h.h.G.t.p.l.l..t.V........s.ta...o..Sp.....p........C.......s......s.....CG..phtpp.....................tls.pR.p.a.....p.....Csp........C...G...hp....tc........RDh........NA.A.hNIht...............................	0	559	1281	1646
+7111	PF07283	TrbH		Conjugal transfer protein TrbH	Vella Briffa B	anon	Pfam-B_17942 (release 10.0)	Family	This family contains TrbH, a bacterial conjugal transfer protein approximately 150 residues long. This contains a putative membrane lipoprotein lipid attachment site [1].	20.40	20.40	20.50	23.50	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.46	0.71	-4.25	14	125	2009-09-10 15:49:04	2003-09-12 16:08:24	6	2	104	0	26	94	9	114.40	33	73.22	CHANGED	ussssptlAsDsVpQLstlYPPApTplpL.....pQtssDsFGtALlpsLRt+GYAVhEhssssttspu....................slsLpYVlDphssosLYRLTl.lGsQoloRsY.lspsushhPAusWs.RKE	.......s...stptlAsDhlppLsphYsP.A.+..T.phpL.....p.p.p.sss.sFGpALlpsLRpcGYAllp.ssssstst................................l.LpYll-phss.ps..LhRlo..lsspplsRsY.hspssshhPuu.hs.h...................................................	0	3	13	21
+7112	PF07284	BCHF		2-vinyl bacteriochlorophyllide hydratase (BCHF)	Vella Briffa B	anon	Pfam-B_17961 (release 10.0)	Family	This family contains the bacterial enzyme 2-vinyl bacteriochlorophyllide hydratase (EC:4.2.1.-) (approximately 150 residues long). This is involved in the light-independent bacteriochlorophyll biosynthesis pathway by adding water across the 2-vinyl group [1].	25.00	25.00	25.70	45.20	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.92	0.71	-4.33	26	115	2009-01-15 18:05:59	2003-09-12 16:40:04	6	1	97	0	54	112	133	138.10	55	81.21	CHANGED	YTPEQhuRRsuSlWThVQuILAPlQFllFLlSlsLVlhYhssG..pGahhsolSIlhKTlhLhhIhlTGAlWEK.VFG+alFAstFFWEDVsShlshAhHshYhlhha.sthsspshhhlAlsAYsoYVlNAhQFLl+.lphu	.YTPEp+tRRDuosWThVQGILAPlQFlVFLlSLsLVlpYLsTG..pGahhAThSlllKThlLasIMlTGuIWEKsVFGpYLFAPuFFWEDVhShlVlALHouYlsslh.shhsspt.MhlALAAYuoYllNAuQFLlK.LRhA.....	0	10	20	37
+7113	PF07285	DUF1444		Protein of unknown function (DUF1444)	Vella Briffa B	anon	Pfam-B_18053 (release 10.0)	Family	This family contains several hypothetical bacterial proteins of unknown function that are approximately 250 residues long.	22.40	22.40	22.40	22.40	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.47	0.70	-5.06	18	530	2009-01-15 18:05:59	2003-09-12 16:42:35	6	4	507	0	70	307	1	250.70	46	91.43	CHANGED	Msscphp-hLccRLs.psshsapaDRcc-sLRIcc+pstKGlTlsLssllAKaccpt-cAl-EllYYVpEulpsM..ppcsp.hpsp-ppIaPVIRuTSFPpco+-Gp..sLlac-HTAET+IYYALDLG+oYRLIDEphLcc.shTcccI+EhAhFNlRsLssshKpDcVAG...NhFYFlsoNDGYDASRILNcuhLp-hpppspGchsluVPHQDVLI.lADIpN-sGYDVLAQhoMcFFspGpVPITuLSFlY-pGcLEPIFILuKs+.+c	............................................................................................................................MsshpM+-cLcc+Lp..+.chcFpas+.....Ec.-sLRI.pp..c.sp.KG.ls..lp..LsullAK.YEsp...K....E..c.h....l-E.ls..........Y.YVpEAlttM...tccs......p.sp....spIhPVIR...uT.....S......Fsc....p..s..........+......pGh..............sF.l.h.c-.....HTAE.TtlYYAlDh..G.K.o.........Y.RLIDEphLpch.pLT.c.p.p.lREhulFNl.Rp....L....ss.p..h...p...p.DpV.pG.........NhFY..FlNoNDG.Y.DAS..RIL.N.suh....Lpc.hct..p.....h..p.G.-.M..l.VAV.PHQDVLI.I.ADI...cNcsGYDlhA...ph...TMcFF...sc...GhVPITSLSFsYcpG+lEPIFILuKNphp..................................................................	0	24	45	61
+7114	PF07286	DUF1445		Protein of unknown function (DUF1445)	Vella Briffa B	anon	Pfam-B_18180 (release 10.0)	Family	This family represents a conserved region approximately 150 residues long within a number of hypothetical bacterial and eukaryotic proteins of unknown function.	25.00	25.00	26.20	28.30	21.20	24.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.74	0.71	-4.53	77	578	2009-01-15 18:05:59	2003-09-12 16:55:20	7	5	524	3	217	535	202	139.80	52	46.66	CHANGED	VuFllGCSFoFEpALlpuG..lslRHl-pspNVPMY+TNlsspPAGhFsGs.hVVSMRPhsssclh+AlpITuRaPss.HGAPVHlG.DP.ptlGIpDlspPDaGDsV.slcsGE............lPVFWACGVTPQsslhsu+...sshsITHuP...GaMllTD	...................VuFllGCSFSFEpALhcsG..lslRHlp..p.spNVPMY+TslsCpsAGh.Fp.....Gs.hVVSMRPlss.spshcAhpITu+aPsV.HGAPVHlG..cP..p.....tl..GIp...Dls+P...DaGDsV.pl..c.sG.E.............................lPVFWACGVTPQuslhsu+.....sshsITHAP...GaMhlTD................	0	58	114	173
+7115	PF07287	DUF1446		Protein of unknown function (DUF1446)	Moxon SJ	anon	Pfam-B_17949 (release 10.0)	Family	This family consists of several bacterial and plant proteins of around 400 residues in length. The function of this family is unknown.	20.10	20.10	20.10	20.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.86	0.70	-5.98	79	939	2009-01-15 18:05:59	2003-09-15 10:38:20	6	15	655	0	436	933	748	308.70	30	63.05	CHANGED	IGsuuGahG...DRhpsshcls....p......tGslDaLsh-hL....................AEhThulht.......ps+hccPs.tG................Yssthhp..phcssLshshc......+Gl+lloNtGuhNPpu.....sActltplApchGLs.l+VAhVp.....GDDlhspltt.....tst..p.hpsut.sh.t...t...hl............SANAYLGAhuIscALctG.ADlVlTGRVsDsulhluPhhacFGWs.hsDaDcLAtuslAGHLlECGuQsTGG.Fuc..ac-l....s-.htpl..........GFPIAElssDGsslITKhs.GoGGhVohsTVpEQLLYElpcPtsYlsPDVsuDasslplp.....phGsDR..................V+V..sGspGps....Pss.hKVslshhsGahspsphshsG.ssht+Aclstchlpc+lttt.........sclch-LlG	...................................................................................................lussuuh.u...Dp..sh.thh.....p...........s..lshlhh.-hL....................uEhsh.hht..........tp...t.pst.....G........................Yt.......hhp..thc.....hLshs....hc......p.sl+l.lsN.....s.....G...uh..sP..tu........hsp.tlpplupc..hGls...h+lAhlt...GDslhshhtphh..........t.......h...s....h.........p.............h..........................sssAY...lGu.sIhcALct....G..A..D..lVlsGRssDsulhhu.s.hh.htasWt.....hs..D......aD.pL..utuhhsGHllECusps.oG.G.ast.........ht.h...............t.h.p.GaPl.uEltsc....GphlloKh.....s..oGGhlo.sTlstQhLYElpsP.tYh.sPD.......Vsschsplp.hp.....ph....u.s.c.R..................Vpl..sGsc....G.p..s.s.....P.s.s...hK.lsh..shhsGapsts.hshsG.t...h.t+u.chhtc.lpptltth..............................................................	0	119	255	370
+7116	PF07288	DUF1447		Protein of unknown function (DUF1447)	Moxon SJ	anon	Pfam-B_18163 (release 10.0)	Family	This family consists of several bacterial proteins of around 70 residues in length. The function of this family is unknown.	25.00	25.00	25.50	25.30	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.34	0.72	-4.19	33	1005	2009-01-15 18:05:59	2003-09-15 11:09:40	6	1	979	0	87	267	1	70.70	51	96.82	CHANGED	IYKVaYQcsppcsPhREpTcoLYl......EA-ochcsRphl-cp..sYNIEFIp.LsGpaL-YEKpsssFclsEa	.....IaKVFYQEs+ccsPhREsTcoLYl......Eu-uchpsRphlc-p..sYNIEFIphLsspaL-YEK.E.s..u.s.FplsEh......	0	18	42	65
+7117	PF07289	DUF1448		Protein of unknown function (DUF1448)	Moxon SJ	anon	Pfam-B_18223 (release 10.0)	Family	This family consists of several eukaryotic proteins of around 375 residues in length. The function of this family is unknown. It appears that this family includes a divergent GRAM domain.	20.40	20.40	30.00	27.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.04	0.70	-5.52	13	172	2012-10-04 00:02:25	2003-09-15 11:11:37	6	9	121	0	110	157	4	282.90	47	87.44	CHANGED	thWpDR-l+FD.lsspplphp..sGEtllshlssVEDTKGNsGcpGpLhVTNLRlIWaupsps+hNLSIGassItslss+.ps..pS+lRG.sopuLaIhu+..ssssRFEFlFT.............................ssstpssp........lFsolhsVa+sYpooplYR-LKLRuAllp.sGpLplLPpEplhs+lsGVhNlSu-QGsL.GoFhlTNlRlVWaAshN-sFNlSlPYLQIpulRlR-S.KaGhALVIETsppuGuYVLGFRlDPh-+LschhKElsSL+psastpPlaGlphphc....-ssttt.............psp..................s.p.pp--sE.l-schcsD...thsuYhAs..sspt.....sp-Rc....PlYssELGLAlE+l+sGhoLp-LWslh	...........s.hWpDR-l+FD..lstpthphR..sGEhll-plsslEDTKGNsG.....-pGpLhVTNLRllWaSh.shs+.hNLSlGasslhslss+.hs....pSK.........lRG.topA......LYIhs+........hs..soRFEFlFT.............................slsstss..........lFsolhsVa.+AYcoo+hYR-lKLRu.A.llp.stpLhlLPpEplas+lpGVWNLSo..D...............QGNL.GoFhlTNlRlVWaAshN-sFNlSlPYLQlp..ul+lR-S.KFG.ALVlcosp.puG.GYVLGF+lDPhE+LpphhKElsSLHpsastpPlFGVpaphc....-t..t.h.......ct................................s.p.h.--hE.l-p.p.pp-......shsuYaAs..ssp........ttpRt.......Psas.cLGlAhEtlhpGholpsLWpl....................................	1	50	59	90
+7118	PF07290	DUF1449		Protein of unknown function (DUF1449)	Moxon SJ	anon	Pfam-B_18269 (release 10.0)	Family	This family consists of several bacterial proteins of around 210 residues in length. The function of this family is unknown.	21.60	21.60	22.10	22.10	21.00	20.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.25	0.71	-4.98	3	565	2012-10-02 01:11:51	2003-09-15 11:14:22	6	1	525	0	47	238	9	190.70	56	95.09	CHANGED	FA-YNoPYLFAIAFVllIGlLElloLIsGHhLSGALDAHLDHYDulSoGsluQALHYLNIGRVPALVVLCLLAGaFGLhGILIQHuuIMVWQuPLSNLllVPlSlllSVhAVHYouKIlAPWIPRDESSAlsEEEaIGuMAlITGHsAsuGsPCEGKlTDpFGQIHYLLLEPE.cGK.FcKGDKVLIVCR....LSATRYLAEpsPa	..............................................................FA-YNoPYLFAIuFVlh..IGl..LEhhuLIhGHh.......LS.......GA...L.........D....A....H..L........D...H.........Y.........D...u......l......o...o..G..........h...u...Q.....A......L.H....YLNIGRlPALVVL...CL...LA...GaF.G.LhG..ILlQH...u.s.lhl...WQ...uP...LSNL....h......l.....V....Pl.Sll..h..olhAVHYoGKllAPWl.PR..Dc..SS...A...loEEEaIGuM.AlI...TG.Hp...A...suGsP.CEGKlTDpFGQIHYLLL.E.PE..cG.K..F.pKGDKVLIlCR.....LSATRYLAEps.a...........................................	1	10	23	35
+7119	PF07291	MauE		Methylamine utilisation protein MauE	Moxon SJ	anon	Pfam-B_18306 (release 10.0)	Family	This family consists of several bacterial methylamine utilisation MauE proteins. Synthesis of enzymes involved in methylamine oxidation via methylamine dehydrogenase (MADH) is encoded by genes present in the mau cluster. MauE and MauD are specifically involved in the processing, transport, and/or maturation of the beta-subunit and that the absence of each of these proteins leads to production of a non-functional beta-subunit which becomes rapidly degraded [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.17	0.71	-4.66	5	457	2012-10-02 13:32:46	2003-09-15 11:20:18	6	7	374	0	184	485	112	150.00	21	71.32	CHANGED	pslLs-PsVshhlRlFLALLLAAAAIPKLRHsEEFaGVVRNFRLLP-aLuRPVAhVLPllELulAVGLllPsLAslAAslAAALhlVFulAIAINVuRGRTpIDCGCFRNGhK.QRISWhhVhRNluLAuhALulAAlLPsAssuSlp-uATGLAAAuhLhLLYhuASLLuGLPAu+susclsKG	...................................................hhh..........hhhphhlu.hl.hlhuuhtK...lt...sh...t....s...F...t.p..t.l...t...s..Y.p...l..L..s....p...t.h..s...t....h.A....hhlPhhElhs.Gl...hLl.h.......u..h...h.........t...h.h..u...u..h..l.uh..h..lh..h..l.Fs..s.ul.....s.h.s.l.h.p..s..t.h.pl...c...CGC.....h........G.........s..s........st............l.u.....h.....h.........l.h..c.sh...h...h.h.hh...s....h....................................................................................................hhhh....................................................	1	82	146	168
+7120	PF07292	NID		Nmi/IFP 35 domain (NID)	Vella Briffa B	anon	Pfam-B_17864 (release 10.0)	Domain	This family represents a domain of approximately 90 residues that is tandemly repeated within interferon-induced 35 kDa protein (IFP 35) and the homologous N-myc-interactor (Nmi). This domain mediates Nmi-Nmi protein interactions and subcellular localisation [1].	25.00	25.00	25.10	25.90	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.97	0.72	-3.94	4	209	2009-01-15 18:05:59	2003-09-15 11:26:57	8	4	39	0	112	182	0	86.40	37	52.28	CHANGED	ALITFEc.cVAppVlp.pcHpVphE-spL+VpspPl.LssssphQVpsplSph+l.VTGhPs..cLSEEphhDKLEl.FuKoRNGGG-V-	..............AlITFtcpt...VAppllphpcapltl.........p.psp.hpVplpPh..sphpchQl..psplSp..+p.lL..VoslPs..tlsE-pl.p.DhLElaFpKspN..GGGEVE..........	0	4	13	43
+7121	PF07293	DUF1450		Protein of unknown function (DUF1450)	Moxon SJ	anon	Pfam-B_18439 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 80 residues in length. Members of this family contain four highly conserved cysteine residues. The function of this family is unknown.	20.90	20.90	20.90	21.50	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.65	0.72	-4.00	14	826	2009-01-15 18:05:59	2003-09-15 11:43:57	6	1	437	0	89	264	0	73.70	40	85.85	CHANGED	MpPllEFClSNLApGoptAhEtLE+DPNlDVlEYGCLoYCGhCupuhFALVNGEhVpG-oPE-LVcNIYpaIEENs...hF	...............................................p.h...hpcL.E..p.D..Ps.s..-llEhGC.oYCG.spcpsFAhVN..scsVtu.T.EELlpplhpplcc...............	0	29	56	73
+7122	PF07294	Fibroin_P25		Fibroin P25	Moxon SJ	anon	Pfam-B_18451 (release 10.0)	Family	This family consists of several insect fibroin P25 proteins. Silk fibroin produced by the silkworm Bombyx mori consists of a heavy chain, a light chain, and a glycoprotein, P25. The heavy and light chains are linked by a disulfide bond, and P25 associates with disulfide-linked heavy and light chains by non-covalent interactions. P25 is plays an important role in maintaining integrity of the complex [1].	25.00	25.00	45.70	39.70	19.40	19.10	hmmbuild  --amino -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.05	0.71	-4.83	5	11	2009-01-15 18:05:59	2003-09-15 11:48:57	6	1	8	0	5	8	0	184.30	46	86.22	CHANGED	NIVRPCaLDDLKCIuDNLAANS+CpsNVRGpIPSpYsIPsF+FEsPFFNATYIDaNLIsRN+DpCRVSEFFFNl+ocsuVLolDCPNLsaESsRTllQHtSLpEDoVYSYaINGTYPLIRLTTNLssusclNLCSuaTFADVs.uLPIF+IDPND+pTANaLSRDLoLLNIYERETFaaRustLARaFINSLICDFGCp	.pIhRPChLsDhcCIpDpLAANSpCpss.tGplPopYpIPhFpF-sPaFNATYlDaNLlsRNpDpC+VSEFahNh+ocpsVLolDCP.LsaESsRTlhQHtS.hpEDshhSaaIpGoYPLIRLTTsh.pusphsLCSuaTFADls.uLPIF+IsPpDp.TApaLS+DLoLLpIYEREphhh+ts.LhR.FlsphlCDFGCp.................	0	4	5	5
+7123	PF07295	DUF1451		Protein of unknown function (DUF1451)	Moxon SJ	anon	Pfam-B_18524 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein. The function of this family is unknown.	24.10	24.10	24.50	24.20	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.00	0.71	-4.42	31	784	2009-01-15 18:05:59	2003-09-15 11:51:52	6	4	781	0	106	305	19	140.40	57	90.58	CHANGED	lhppl....p-s.pps.cpLpchlcpucchhptts-hTc-ElsLlspaL+RDLccatcphp-.......t.hpushhthlcpoLWptLupITD+TplEWtELhpDhcHpG..hYpoGEllGhGtLsCppCG+phphppsshlssCscCspptFpRpsh	...............................L.VASL....oE.RL+NGERDIDsLVEpARcRVhpsGELTRsEl-plocAVRRDLEEFAhSYEE................pppDSVFhRVIKESLWQELADITDKTQLEW....REVFQDLsHHG.....VYHSGEVV.GLGNLVCEKCHaHLsl.Y.T.P.-.V.LshCPKCGHDQFpRRP.F.......	0	23	49	77
+7124	PF07296	TraP		TraP protein	Moxon SJ	anon	Pfam-B_18635 (release 10.0)	Family	This family consists of several bacterial conjugative transfer TraP proteins from Escherichia coli and Salmonella typhimurium. TraP appears to play a minor role in conjugation and may interact with TraB, which varies in sequence along with TraP, in order to stabilise the proposed transmembrane complex formed by the tra operon products [1].	25.00	25.00	52.10	53.30	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.34	0.71	-5.35	3	150	2009-01-15 18:05:59	2003-09-15 11:56:11	6	2	115	0	4	90	0	182.40	72	98.69	CHANGED	MANNhlop.ts+AshYsVAuVLRWLaWsVKYAVIaPLATMALlVlLVFRTGsTTPGQpLVKEIspVRQpAPuG.FPVpDCssP....usoVsSPlPspLQEsCsh+ITDAA-YAA-IDQSLoQslhhLWuhLALlYTulAVlhG+pPVR+Ghl+p.tVVsuDosLss.thI.tcsEVhT.csshsGQI++s.....sD+pu+sEGDKNEHT	.........MuNNhSuRQAsHAsRYVVApVLRhLFWCLKYsVILPLATMALMALFVLWKDNTTPGKLLVKEIsFVRQTAPAGQFPVuECh.............hsoSD......S...ss.u...plp.-IC+YRAADAADYVRETDRSLMQLVTALWATLALMYsSlAAhTGKYPV.RPGKMK.ClRVVTADE+L.........KEVYTEDASLPGKIRKC.VYhPDDRTNRNNGDKNEHA........................	0	0	0	2
+7125	PF07297	DPM2		Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)	Moxon SJ	anon	Pfam-B_18649 (release 10.0)	Family	This family consists of several eukaryotic dolichol phosphate-mannose biosynthesis regulatory (DPM2) proteins. Biosynthesis of glycosylphosphatidylinositol and N-glycan precursor is dependent upon a mannosyl donor, dolichol phosphate-mannose (DPM). DPM2, an 84 amino acid membrane protein expressed in the endoplasmic reticulum (ER), makes a complex with DPM1 that is essential for the ER localisation and stable expression of DPM1. Moreover, DPM2 enhances binding of dolichol phosphate, a substrate of DPM synthase. Biosynthesis of DPM in mammalian cells is regulated by DPM2 [1].	25.00	25.00	28.20	28.00	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.87	0.72	-3.70	12	227	2009-09-13 06:50:04	2003-09-15 12:00:32	7	4	200	0	152	198	0	74.20	39	80.80	CHANGED	tsD+lVGhuhlshShhlFsYYThWlllLPFlDssHslHpaFLPRsaAlhlPllhsllhhhhlGsFluhVMlKop+..KKu	.........h..DphlGhhhlhsuhhlFhYYThWsl.lhPF..l....D..s...s..H.slppaF.P..RtaAlhIPlhhhllhhshVGsFluhVhl+spp..Kc.....................	0	36	75	120
+7126	PF07298	NnrU		NnrU protein	Moxon SJ	anon	Pfam-B_18406 (release 10.0)	Family	This family consists of several plant and bacterial NnrU proteins. NnrU is thought to be involved in the reduction of nitric oxide. The exact function of NnrU is unclear. It is thought however that  NnrU and perhaps NnrT are required for expression of both nirK and nor [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.58	0.71	-4.92	102	551	2012-10-01 22:51:20	2003-09-15 12:54:25	6	2	458	0	223	592	305	193.30	25	85.69	CHANGED	lLlhulhlFhusHhh.h.ssshRsthh.utlGctsa+uhaullSlsulslllhuattAchs....LWsss..shhttlsslLhhlAhlllsuuhh.sp..................IhthsRHPhLhuhtlWAlAHLLsNG-lssllLFGuhhsaAlhshhhhc+R........sts.hs.hhsssuhhs..................shhslshGlllahslhh.hHshL.hGlsP	........................................................................................................hllh.LhlFhs.tHSlhh..tsshR.thhh..thl..G....t..t..t...a+uhY.ullSlsu.lsl..l..lht..atttphs......lWss.......shhphls.hh.Lhh..lu.al..hlhsuhh.hpt.......................................lhphsRHPh.h.lG..h..h..l..W.....A.....h.....uH.hlss.Gs....h....hsl.lhhsuh.hhatlhshh..hcp+.........ttt..ht.......sshh.......................hhhhhhulhhhhhhhh..hH.hl..t.............................................................	0	59	136	172
+7127	PF07299	FBP		Fibronectin-binding protein (FBP)	Moxon SJ	anon	Pfam-B_18450 (release 10.0)	Family	This family consists of several bacterial fibronectin-binding proteins which are thought to be involved in virulence in Listeria species [1,2].	22.70	22.70	22.80	23.30	21.70	22.60	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.37	0.70	-5.00	15	400	2009-01-15 18:05:59	2003-09-15 13:05:05	6	1	377	6	70	289	14	187.30	36	93.28	CHANGED	FIcsaQYNaIKpplppLlsuasosNDcsslpsl+uhst-KIhslFsclssEpcpllcslhslp.s+pcA-+aLpcLp.YVlPFppsospplpKLF+KsKKLKlPshcphDh+phoYLGWNDtGop+KaIlhhp.csKLhGlpGslss..pspKGlCoICs...pco-VuLFhupsK.uss.sGTYs++GNYICtDSppCNcplTslspLccFlccl+	................................hIps.QaNhIKpph..LhpsatosNDttslpslpuhs.-KI.tlF.p.t.............t...p.t.llsplhshp.sptcAEphL.plp.hVhPF.tsos.plpKlF...........KsKK.....LKl.P.s.hpphD.h+choYlGWpD.h.u.o.p.R.K.allshp..cs......+hlGl....p....Gohss.......ph....pKu...l....ColCp...sp...s...pVu..hFhuppK....usu....sG.s.asppGNYICpDu.tCNpphpphphLppFhc.lp.................	0	26	55	66
+7129	PF07301	DUF1453		Protein of unknown function (DUF1453)	Moxon SJ	anon	Pfam-B_18607 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown. Members of this family seem to be found exclusively in the Order Bacillales.	21.60	21.60	21.60	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.00	0.71	-4.34	20	613	2009-01-15 18:05:59	2003-09-15 13:44:42	6	1	432	0	59	304	1	143.10	50	92.91	CHANGED	M........hslhSolhAlhMuhhlhhl.RhKAuc+Ps..osKKIILPPl.....F.MSTGALMFl..hPhFRlosh-llEAlhlGhl.FSlhLItTS+FElR.sscIYlKRSKAFsaILlGLLllRlshKhhluspIDhupLuGMFalLAFuMIVPWRIAMalpY+Kl	............h...hlhS.llAlhMushlhhl.RhKA..tp..pPl..stKK.IlLPP.h......F.MuTGA.LMal.......hP.hFRL.Ts.h..EhLEAhhlGLl.FShhLIhTS+FEl+..sscIYhKRSKAFshILIuLL.llRhshKhalS.....s..p..lD.GpLuGMFFLLAFsMIVPWRlAMhhpa+KL.............................	0	17	34	45
+7130	PF07302	AroM		AroM protein	Moxon SJ	anon	Pfam-B_18608 (release 10.0)	Family	This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL [1]. The function of this family is unknown.	23.10	23.10	23.20	29.60	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.31	0.70	-5.01	15	531	2012-10-03 04:39:14	2003-09-15 13:50:37	6	2	525	0	48	185	10	220.50	70	98.21	CHANGED	+lAllTIGQuPRs-VlPplpcals-shclschGhLDuLScpEI.schAPpss-.csLlThLsDGppVplS+pKlpctLQpsIptL-ppGh-lIlLhCTGpFs.sLss+ps.LLEPp+IlssLVsullss.pplGllVPlt-Qhs..hptpKWphltpsshhssAoPah.uopsclhpAuppLttpGADllVLDClGYsppp+chlpcthslPVlLupsLlARl....suELls	.........................................S.LAILTIGlVPMpEVLPLLTEYIDE.-.pIoHHSLLGK.....L...S...REEV..MAE...YAPEsGE.DslLT.LLNDN...QLAH....VSR+KVERDLQuVVEVLDNQGYDVIlLMSTAsIu.SMTARNoIhLEPsRILPPLVuSI..V-c..HQVGVIVPVEEhLs...sQAQKWQl.....L.Q.+sPVaSLuN.PlH....sS....E...Q....clIDAG+ELLscGADVIMLDCLGFHQ.RHRDlLQKpLDVPVLLSNVLIARLAAELL.V...........	0	6	18	33
+7131	PF07303	Occludin_ELL		Occludin homology domain	Vella Briffa B, Bateman A	anon	Pfam-B_18556 (release 10.0)	Domain	This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localises to tight junctions [1], while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA [2]. This shared domain is thought to mediate protein interactions [3].	25.30	25.30	25.80	26.10	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.51	0.72	-3.28	18	504	2009-01-15 18:05:59	2003-09-15 14:23:59	8	8	105	3	247	398	4	98.70	38	19.03	CHANGED	YPP.IsSscpRpcYKp-Fss-apEY+pLpAEl-slsc.+hspL-ppL.cpLsc...sSpcYpslt....cEYp+.lK..KpsssYppKKpRCcYL+sKLsHIKphls-YDc	.................YssIpSt-QRppYKp-Fss-YsEY+pLpAclpslsc.+FpcL-spl.cpLsp.........uopEYp...............plp.plhpEYp+h+............KpsPsYppcKpRCcYL+sKLuHIKphI.t-YDp...............	0	29	55	137
+7132	PF07304	SRA1		Steroid receptor RNA activator (SRA1)	Moxon SJ	anon	Pfam-B_18506 (release 10.0)	Family	This family consists of several hypothetical mammalian steroid receptor RNA activator proteins. SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines. SRA-RNA is a steroid receptor co-activator which acts as a functional RNA and is classified as belonging to the growing family of functional non-coding RNAs. 	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.97	0.71	-4.50	4	239	2009-01-15 18:05:59	2003-09-15 14:28:43	6	16	207	1	163	255	0	157.30	24	18.02	CHANGED	hsPPs.........PsSstsssPP.GpG...PsSup.......lpPssscP-....s-tshcsshhsLcpslpsspsShcpplssDIoRRLplLp-.WtGGKLShsV++RMshLspELpstpWDuADcIHhSLMVDHVsEVSQWMVGVKRLIAEsRpLs.c.ht..pputu............QsS	.....................................................................................................................ssssss..............P........t..s...s..ss...s.t...s.............s....Ps.s.s..................................ht.s..s...st...s.p............spt....l....p..ll.p.s....L.pp....sh.p.......t........s....s....s.s.....h....pK...p........h.......c...Dsp+RLslLF-+.L.s.s.s.c.Lo.ps.s.h.cph.tpLspuLps+c.acsAppIHhslh.s..s..+s...s..EsupWhs..........GVKRLIsht...................ss..............	0	41	81	130
+7133	PF07305	DUF1454		Protein of unknown function (DUF1454)	Moxon SJ	anon	Pfam-B_18833 (release 10.0)	Family	This family consists of several Enterobacterial sequences of around 200 residues in length which are often known as YiiQ proteins. The function of this family is unknown.	25.60	25.60	25.70	75.50	24.30	25.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.31	0.71	-5.22	4	549	2009-09-10 15:53:58	2003-09-15 15:29:10	7	1	541	0	42	161	0	197.90	76	99.52	CHANGED	M...K.hshLahhhhhuLslsssA.cApT.s-T.TssAPYLLsGAPoFD.SISQFRE+FNusNPoLPLNEFRuIsopsD+sNLTRAASKINENLYASTALERGTLKIKSlQhTWLPIQG.PEQKAA+sKA.EYMuAllRsFsPphSpsQSpp+LppLLssGKsKRYaocsEGAlRYlVADsGEKGLTFAlEPIKLALSEoLEG.NK	..............................MKPGCTLFhLLsSAL..Tlo...s.T.A...H.AQ..o....s-o.sTTAPYLLAGAPTFDLSISQFREcFNsQNPoLPLNEFRAIDSSsDKAN.LTRAASKINENLYASTALERGTLKIKSlQhTWLP...IQG....PE.Q...............KA............A........KAKA.EY......MAAlIRTlsPLhTKs...QS...QK...KLQsLLTA.GKsKRYYsET.EGAlRYVVADNGEKGLTFAVEPIKLALSEoLEGhN........	0	1	10	25
+7134	PF07306	DUF1455		Protein of unknown function (DUF1455)	Moxon SJ	anon	Pfam-B_19038 (release 10.0)	Family	This family consists of several hypothetical putative outer membrane proteins which appear to be specific to Anaplasma marginale and Anaplasma ovis.	25.00	25.00	241.90	241.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.57	0.71	-4.09	2	8	2009-01-15 18:05:59	2003-09-15 15:31:47	6	1	4	0	1	7	0	130.00	89	99.62	CHANGED	MSCRAF.L+GlLhFsLLPGSLAT.ARP.LLtVsstsuhtQTsGGG..hsttASsThG+LssAsAsSAspS.tl.uSsVhEsGh.sphhSPAQ..ELhusALQPS.TPSSWVFGRTAhSGVRuFLERTVFLVF	MSCRAFSLKGLLAFTLLPGSLATAARPSLLRVGGEASGQQTSGGGFHAAGGASATRGRLTSASAVSAPQSFGVLGSTVWEDGFLPSVFSPAQ..ELLSAALQPSPTPSSWVFGRTAISGVRGFLERTVFLVF.	0	0	0	1
+7135	PF07307	HEPPP_synt_1		Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1	Vella Briffa B	anon	Pfam-B_18592 (release 10.0)	Family	This family contains subunit 1 of bacterial heptaprenyl diphosphate synthase (HEPPP synthase) (EC:2.5.1.30) (approximately 230 residues long). The enzyme consists of two subunits, both of which are required for catalysis of heptaprenyl diphosphate synthesis [1].	29.40	29.40	29.70	29.40	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.18	0.70	-4.88	15	387	2009-09-13 14:07:00	2003-09-15 15:36:15	6	2	383	0	41	188	0	175.40	39	77.92	CHANGED	HsYLtcaIstPhlDEDKLhLLashhs-us..lpppct-cYllTsMLVQlALDTH-cVos.tst.sspspKsRQLTVLAGDYYSGLYYpLLScscDIslIRsLApuI+EINEpKIpLYp+pspsl-plhpSVspIESALlp+lu-+Fthsp.WpphsscaLlh+RL.pEpcha.pttsS.lhcsltph....cstsshcslhp-thcclpcthpphlcp	.............................................................................................................................olLhGDhhSuhaYpLLAEhsDlsh.ptlucAIhEINEhK.sL.a....pp.A.h...s...s...h...E.I.pulVpIEohh.hhT...h...sHFtl...................................................................................s...........................................................	0	13	27	33
+7136	PF07308	DUF1456		Protein of unknown function (DUF1456)	Moxon SJ, Yeats C	anon	Yeats C	Domain	This family consists of several hypothetical bacterial proteins of around 150 residues in length. The function of this family is unknown.	21.70	21.70	22.00	21.80	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.99	0.72	-3.94	117	1896	2009-01-15 18:05:59	2003-09-15 15:37:37	8	2	957	0	262	965	68	68.40	41	85.24	CHANGED	NNslL++LRhALslpcschlclhthus..hplo+s-luuhh..+K.........c-cc......sYp.pCsDphLpsFLsGLhhppRG	....NN.lL++lRhAhslps..s..DllcILshss..hclott-lsuhhRK.................c-cc...............sap.cCsDphLptFLpGLhhcpRG...........	0	60	125	200
+7137	PF07309	FlaF		Flagellar protein FlaF	Moxon SJ	anon	Pfam-B_19331 (release 10.0)	Family	This family consists of several bacterial FlaF flagellar proteins. FlaF and FlaG are trans-acting, regulatory factors that modulate flagellin synthesis during flagellum biogenesis [1].	20.60	20.60	21.40	21.60	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.48	0.71	-4.21	50	272	2009-01-15 18:05:59	2003-09-15 15:41:24	6	2	230	0	103	219	28	112.40	32	93.77	CHANGED	M........stpAYupstp.sstosRphEtpsLs+ssppLppup.....spsstshpth......cALhhNR+LWohhtsDlups-NsLPpcLRAsllsluhFlh+copclh..ttp.s..slpsLI-INpsIhsGL	...................ht.tYtcshp..sstss+-pEttlhs+uhshLpsAp......tpsspshpsl......-Alhasp+LWohlhsDLs.ss-NsLPp-LRAsllSlulaVh+cspclh..psps..pshpsLI-IspsItcGL...................	1	30	63	77
+7138	PF07310	PAS_5	DUF1457; 	PAS domain	Vella Briffa B	anon	Pfam-B_18761 (release 10.0)	Domain	This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. This region is is distantly similar to other PAS domains.	20.60	20.60	20.60	21.40	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.50	0.71	-4.62	10	302	2012-10-04 01:10:46	2003-09-15 15:59:54	8	1	218	0	104	274	26	135.90	26	68.99	CHANGED	M+psSotplFuYWsclRsucs....sP+RuDI-Pucl+sLLuDsFlLps-usGshsFRLAGTRLCsLhGc-L+spsFsuLas.ssRpclscllssVhccsssslsslsutspsGss.lchElLLLPLpscsssssphLGlLs	.............................................shhtlhsYWpp.l.pt..s.cs..........hPtRps.lDPt.cl.t.p...hLssl..F...lL..E......p..p.....s.t.....u..p...h.ph.RL....A..GT+lssla....Gp.-l+...Ghph.ss...l..astp..s.........p.t..t.l.t..chlps.Vhppt.ssshhths......u.h....shsu....pt..lph-h...lLLP.Lt.sssst..phlGsh.s.............................................................	0	44	69	80
+7139	PF07311	Dodecin	DUF1458;	Dodecin	Moxon SJ, Anantharaman V	anon	Pfam-B_18876 (release 10.0)	Family	Dodecin is a flavin-binding protein [1],found in several bacteria and  few archaea and represents a stand-alone version of the SHS2  domain [2]. It most closely resembles the SHS2 domains of FtsA and  Rpb7p, and represents a single domain small-molecule binding form[1].	21.00	21.00	21.10	27.40	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.73	0.72	-3.94	80	611	2012-10-02 11:08:51	2003-09-15 16:03:34	7	2	529	137	255	516	39	65.40	41	90.96	CHANGED	+lYKhlEllGoSspSh--AlpsAlscAu+Tl+slcWhEVtEh+uclcs.G+VscaQVslKVuFcl-s	......plYKllEllGoSspSh--AIpsAls+Au.....cTl+slcWFEVs-hRGclcs.GclsaaQVslKVGF+l-........	0	69	170	227
+7140	PF07312	DUF1459		Protein of unknown function (DUF1459)	Moxon SJ	anon	Pfam-B_18877 (release 10.0)	Family	This family consists of several hypothetical Caenorhabditis elegans proteins of around 85 residues in length. The function of this family is unknown.	20.80	20.80	21.00	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.06	0.72	-4.06	2	33	2009-01-15 18:05:59	2003-09-15 16:05:31	6	1	5	0	33	26	0	81.00	47	98.45	CHANGED	MFQKohIVhhhALFCISSsQVlYoPEVVuSPYYYuuuPVA.SAYPYAYAYGAsAYPTAaYGWGSNKGQQA.uSA.PTQKLTNNQ	.........MFpKshh.sl..hls.h.F.sl.uSsQllao.PphVsu..PYYYAu.ussu..AYP.sYu..Y.u..AAAYPos.auWGSNKsp.p..u..s.u.sA...PTpp..LsNN..................	0	8	16	33
+7141	PF07313	DUF1460		Protein of unknown function (DUF1460)	Moxon SJ	anon	Pfam-B_18925 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 260 residues in length. The function of this family is unknown.	21.30	21.30	21.40	21.40	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.34	0.70	-5.14	25	430	2012-10-10 12:56:15	2003-09-15 16:07:39	7	5	420	3	68	330	60	209.60	41	72.81	CHANGED	tlSptFLGTPYtAspLhGussss..EpLVlcFcGlDCFTalDYVtALp+uss......pssFlcsLhchRYtsGcl.sFhsR+HFFo.DWstssspt..scDlTsplSs...........thlohsKpLNp............Ks-GspalsGLslhcRsl.........sYIPustl........sppVlspL+oGDaIGIYoph........sGLDVTHsGlhltsssu....shhRNASStpss.pVVDsPFh-YlpspP...GI	.....................................................................p.lSptFLGTPYpA....sTLhtsssts..EtLVlNFsGlDCFTalDYV.ALupuss...........ppsFhcsLtphRYts.Gcl...uYhsR+HFFo.DWhsssspp..AcDlT.s...plSs..............phlshsKpLNp..................................................................K.s-GuEalsuLulh.Rpl.............sYIPu..ctI.........................spp..V.h..sp..L+sGDhIGlYosh.................................................sGL.DV...oHlGIs..lp.ccsp.........lhhRNASSlttp...+.VV..D..pP..Fh.-Yh+spP.....GIl.......................	0	15	36	58
+7142	PF07314	DUF1461		Protein of unknown function (DUF1461)	Vella Briffa B	anon	Pfam-B_18854 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 200 residues long. These are possibly integral membrane proteins.	24.00	24.00	24.20	24.70	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.36	0.71	-4.54	40	875	2009-01-15 18:05:59	2003-09-15 16:09:30	6	1	849	0	104	563	21	180.00	35	82.83	CHANGED	h+.......p.h....hslhhhlhlluhulhhslhht..h.hY.hplchhplschss............hshsplhpNaspLhsYLssshppt.Lphssh.sSssG..........hhHFt-VKpLFhhshhlh.lhsllhhhhhhhhhhpcpphhhhh.pshhl..hh......llPlllhhhh.hlsF-paFshFHplhF.sNshWlFDPspDPlIphLPEpFF	............................................................................................hhht........hhhhs.hlhll.ululhlTIhht..a.h.Y.h-IpaLsls.p..h.l.h..........................ls.ps.lhpNaph.L..hsYLssPapph.LphPcF..sSssG..........................ltHFt-VKpLFhls.hVh...l.l...sl...sh..h..ha..l..p..hl..hK...+.ph.....l...th.hh......+.....shhh..hh.............llPl..h.lulhh..hlsF-pFFslFHpllF.ssDsWLFDPspDPlIhlLPEpFF............	0	37	66	84
+7143	PF07315	DUF1462		Protein of unknown function (DUF1462)	Moxon SJ	anon	Pfam-B_19094 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 100 residues in length. The function of this family is unknown.	25.00	25.00	32.90	109.50	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.14	0.72	-4.02	18	399	2009-01-15 18:05:59	2003-09-15 16:17:21	6	1	399	1	35	144	0	94.40	59	87.33	CHANGED	sVYGA-slCASCVNhPSSK-TaEWLpAALpRKYPsp..sFchpYIDIp.pPs-s..-cpp.caup+Ih-DEhFYPLVllsDElVuEGNPpLKsIapphE	.hVYGA-VICASCVNAPoSK-TY-WLQshLtRKYPs...sFpasYIDIpc-s-s..-.cchpFhERI.pDELFYPLlshNDEhVA-G..phKpIhchI-.	0	9	20	29
+7144	PF07316	DUF1463		Protein of unknown function (DUF1463)	Moxon SJ	anon	Pfam-B_19113 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 140 residues in length. Members of this family seem to be found exclusively in Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	25.00	25.00	25.50	57.20	18.90	17.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-4.59	2	115	2009-09-10 14:48:10	2003-09-15 16:19:18	6	1	27	0	9	71	0	135.40	73	98.69	CHANGED	hpaYsLc.laFShsss.lcoGpLEhooEPsshAhhSoED+shPl.ShRDP+TlsalFslEVohGShDYhLLTcLSsEQFYp.sV.KpcKhhcLsFNDphuhKIISN.AhFsE.PoRpYSA-s-pVpFpI+AINCphpKss	.....MQFYDLREVYFSIGG.sQLHSGKLELTSEPTTRAVlSoEDKGhPVISLRDPKTITYlFNIEVTLGSaDYILLTELSDEQFYNMDVpKpDKMLDLsFNDRIATKIISNYAIFTEEPSRSYSAEAEKVoFEIRAINCQKoKPN.....	0	5	5	5
+7145	PF07317	YcgR		Flagellar regulator YcgR	Moxon SJ	anon	Pfam-B_19142 (release 10.0)	Domain	This domain is found N terminal to Pfam:PF07238.  Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias [3].	21.10	21.10	21.30	21.10	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.02	0.72	-4.30	7	656	2009-01-15 18:05:59	2003-09-15 16:24:08	7	2	640	2	95	297	19	105.70	50	43.27	CHANGED	pFlhps.htIsshLR-LpKpps.lplp.tspGp..hlS+ILslsPppt.hlhDaGutEp-NptsLputplshlspspGsKlEFsssplppscapshPAFpstlPppLahl	..........QFLKpNPLAlLGVLRDLpKsslPLRlS.Ws.sGQ...hISKILslsP-K..Lll...DaGSQsc-Nh..AVL+Apc.lsIsA.ETQGAKVEFTl.p.Q.L.pp.u.EY.p.LPAFIT.s.PsoLWFV...........	0	9	42	68
+7146	PF07318	DUF1464		Protein of unknown function (DUF1464)	Moxon SJ	anon	Pfam-B_19143 (release 10.0)	Family	This family consists of several hypothetical archaeal proteins of around 350 residues in length. The function of this family is unknown.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.07	0.70	-5.63	11	65	2012-10-02 23:34:14	2003-09-15 16:32:55	7	1	62	0	43	226	2	317.30	32	93.36	CHANGED	GIDPGTsSaDlsul--..GpVhhctslPTspVtcsPthllchlp-s.....ss-llAuPSGYGLPlh+sp-ls-.....c-IhLhTLsssuctu.....hG......LRshlp.h.uu+sl....ssahlPGVIHLsoVPsaRKlN+IDhGTADKlAosshulhp.sc.....Ycsh....sFILVElGtuFoAslAVpsGpIVDGhGGTh.hsG..ahuuGhhDGElAYLhu....plsKphlFpGGht.hss.......................sapthhE.lhKslsshhuoh.csc.....IIlSGRhtphs-htcclct+htch...........h..t..t.sKEuApGuAlIAsuluGGha+cll-hLtl.cSuGTslDal+L	..............................................................................................................................................................GlDPGTc..Shslhhl--..Gplhh..h.......plsop.V....t.cs..shh.l......lchlpch...............ps-hlshPSGaGl.P..ltp.h.pclsc.......c-lh.l..hTlhcs.tphs........hG......Lpchlp.h..tppph....s..sahI.PuVI..c.LsoVP.t...aRKhNpID...hGTA.DKlAs..sshuh.t..pthtl.apps......sFIllEhGhsasuslsVcsG+IVD...G...h..G...G.T.h......h....s......G...h...h...s.G......s..l...D....u....E...l..........A.Yhl...s..............chs..K...ppl......F.....p.....u.....G.h..hst.................t.............t...t..........shcthhE.ll+tVs...sh.h.s.s.h...chp.....Il.l.SG+h.t..p.....-htcchcpphtth..........h............sKE.AA..GuAhIAsulsGGha+chlphl...cupGosl-alp..............................................................................................................................	1	13	21	34
+7147	PF07319	DnaI_N		Primosomal protein DnaI N-terminus	Vella Briffa B	anon	Pfam-B_18931 (release 10.0)	Family	This family represents the N-terminus (approximately 120 residues) of bacterial primosomal DnaI proteins, although one family member appears to be of viral origin. DnaI is one of the components of the Bacillus subtilis replication restart primosome, and is required for the DnaB75-dependent loading of the DnaC helicase [1].	20.20	20.20	20.30	21.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.23	0.72	-3.74	37	1017	2009-01-15 18:05:59	2003-09-15 16:51:55	6	3	1013	1	99	468	1	91.90	35	30.28	CHANGED	MEslscslpc.hhpppshppchpplhppllsDs-VpuFlpp+ptcLopchIp+uhsKLaEalppppchpt....tsssslhpGYpPpLslspthIDVsY	........................MEsltphlpc...ps..p.c.....a.....t.....pchpc.l.h.pclhpDPDVpsFlppct.cLTsp.Ip+SlsKl.EYlsp+c+att....sDss.lscGYpPpLslspshlDlpY...............	0	22	49	74
+7149	PF07321	YscO		Type III secretion protein YscO	Vella Briffa B	anon	Pfam-B_19036 (release 10.0)	Family	This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis [1].	27.50	27.50	29.10	28.80	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.92	0.71	-4.39	12	104	2009-09-13 06:09:03	2003-09-15 17:16:14	7	1	98	0	19	64	2	149.40	38	69.50	CHANGED	M....lppLhcIKphRt-cApptltpQp.tlssA+tcpppAppshpDa+.WRhpEEpRLauphptphlth+-l-chp....ppluhLR-ppApLtpplscttpplctEpptLppppptlppsp+ppEKhsELtcppps-ttt.pphpEEhE.EEFtp.......ph	.....M.lcpLhclKplRh-RAE+AlppQphplpsAttcppcApps.pDY+.WRhcEEpRLFsptpspslsp+-LEpap....ppluhLRE+EApLEpcsAchtcpLcpERccLppspctlppA++pppKFhELtcppps-ptsppchpEEtEtEEFhphp.......	0	7	9	14
+7150	PF07322	Seadorna_Vp10		Seadornavirus Vp10	Moxon SJ	anon	Pfam-B_18930 (release 10.0)	Family	This family consists of several Seadornavirus Vp10 proteins found in the Banna and Kadipiro viruses. Members of this family are typically around 240 residues in length. The function of this family is unknown.	25.00	25.00	42.20	41.80	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.74	0.70	-5.11	2	12	2009-09-21 14:23:59	2003-09-16 09:38:08	6	1	4	0	0	12	0	228.30	59	92.13	CHANGED	MDVLSKuSLKELLAHLE+TPLEEAlSY+IGTlPYQNVLIsRNEYYNQ.YPDsTSLIDGVuREGQRNVNGLIMSIISYVVSGSGHYIPNIGahLLRRSILDILTKHDTGLsTNNlNYslIARNLTVSKMNCEQRKRMLICFKLLAYKDGN.NDYEhYLNQNIsLKQIAPNFIPGDMRTVhpNpDpLuIVGIPAYRLTQSTELSIRDDNAKSYKlGYVDWYNSNSFLRERs-FNLIpLKDRD.	......LSKSSLKELLAHLE+TPLEEAISYKIG.TlPYQNVLISRsEaYNQLYPDsTSLIDGVuREGpRNl.GLIMSIISYVVSGSGHYIPNlGhhLLRRSILDlLT++DTGLsTNNlNYslIARsLTVsKMNCEQRKRMLICFKLLAYKDGN.sDY-sYLNQNloLKQIAPsFIPsDMRTVlSNsDpLSIVGIPsYRLTQSTELSIRDDNAKSYKlGYVDWYNSNuFLRERN-FNLhpLKDRs.h......................	0	0	0	0
+7151	PF07323	DUF1465		Protein of unknown function (DUF1465)	Moxon SJ	anon	Pfam-B_19346 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.	25.00	25.00	28.70	72.80	22.20	20.50	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.81	0.71	-4.66	26	190	2009-01-15 18:05:59	2003-09-16 09:55:55	7	1	189	2	72	161	18	157.20	49	90.36	CHANGED	lphucphstSphFpsLapEGMsLVEETAuYLD.....GtGRspu+sLsRpu....ulsYAsESMRLTTRLMQlASWLLlpRAspcGEMotpQsppEKs+lphssss.....sssshscLP.thpcLltRSpcLptRltRLDcplhst.ssssttt......sPVssQlshLcs.....AF	.......h.phuc+hshSssFcslYtEGMsLVEEsAuYLD.........GcGRp-A+sLs.RsA............uhhYAuESMRLTTRLMQlASWLLLQRAs+pGEMTcsQssuEKs+V+Lcsss..hspsusuas-LP.sht-LlcRShRLQsRVp+lDcclast.s.shpts.....tNPVstQlshL+sAF.........	0	20	42	52
+7152	PF07324	DGCR6		DiGeorge syndrome critical region 6 (DGCR6) protein	Vella Briffa B	anon	Pfam-B_19101 (release 10.0)	Family	This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome [1]. Also found in this family is the Drosophila melanogaster gonadal protein gdl.	23.30	23.30	23.90	24.90	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.26	0.71	-4.83	8	130	2009-01-15 18:05:59	2003-09-16 10:42:51	6	3	87	0	75	129	1	160.30	45	79.11	CHANGED	Mpca.usspt.........hs-pspQ.......QERHYaLLS-LQsLVK-LPSuaQQRlSYosLoDLAhALLDGTVFEIVQGLLEIQHLTEKNLYNQRhKLcsEH+sL+Q-Lt+KHK-ApQ..sC+sHNLulLKssQp+EhEulEpRl+-EQphMDcKIVLELDQKVhDQQSTLEKAGVPGFYlTsNPQElplQMNLLELIhKLQQhp..ssK	..................................................................................Qp+hY.Llp.tLpphhpcL.PpphQpRl.uYshLosLA.sLlss.olF-IVpuLhElQHlTE+pLhppRhplpscap..........h.tpth.hpKhp-spp......t..sH..tLsllpttpp+chc...t...hp.phc-E.p.hDpKIllELDp..KVsDQQSTLEKAGVsGFYVTsNPpElplQMpLL-hI.h+Lppht....................	0	26	32	53
+7153	PF07325	Curto_V2		Curtovirus V2 protein	Moxon SJ	anon	Pfam-B_19350 (release 10.0)	Family	This family consists of several Curtovirus V2 proteins. The exact function of V2 is unclear but it is known that the protein is required for a successful host infection process [1].	25.00	25.00	147.90	147.80	21.90	20.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.48	2	21	2009-01-15 18:05:59	2003-09-16 10:53:44	6	1	17	\N	0	27	0	122.70	76	100.00	CHANGED	MGPFpVsQFPcNYPAhLAVSTSCFhRYNKWCILGI+pElEuLTLEEGEsFLtFQKEVKKLL+hKssFpRKCpLYEcIYKKYl.ssPEcKGp.spshsEEEED.ataEcIPMEEsCspcpssElcDV	MGPFRVDQFPDNYPAFLAVSTSCFLRYN+WCILGIHQEI.EsLTLEEGEVFLQFQKEVKKLLRhKVNF+RKCuLYEEIYKKYVtNVsEKKGE.SSKCVA.EEEE.DhY-..aEEIPMEEsCsKcQc.EVcDV..	0	0	0	0
+7154	PF07326	DUF1466		Protein of unknown function (DUF1466)	Moxon SJ	anon	Pfam-B_19433 (release 10.0)	Family	This family consists of several hypothetical mammalian proteins of around 240 residues in length.	25.00	25.00	31.50	31.00	18.80	18.70	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.57	0.70	-5.06	2	48	2009-01-15 18:05:59	2003-09-16 11:36:18	6	2	29	0	22	46	0	208.10	54	95.22	CHANGED	MASpWQsMtTSVRRRSL.+pEQLEcpc.hpsssuH.ET..GsLGSLCRQFQRRLPLRAVsLsLtsGPSWKRLEoPEPtQQGL..AARSAKSALGAhSQRIQESCQuGTKWLhETQVKsRR.KRGAQKspGSPs.SLSQKsTRLs.....+ustDsh.ttHhRLSspMGsHsH.hpR.RREAAhRSPhSSTEPLCSPSESDSDLEPsGAGIQHLQKLSQcLDcAIhAEEptph.....hp	................................MASpWQuhtsSV..+RRSLpcpEQLE-pcthpPs..suH.ETSsGALGSLCRQFQRRLPLRAVsLN.LssGPSWKRLEoPEPtQQGLQAAARSAKsALGAhSQRIQESCQ.SGTKWLVE...T..QVK..ARR...R.+R..GAQKsuuoPs+S....L........Sp+...ST..RLou..s..sss...p...ust.....s.....shppp......t+pLSs....hG.scApP..hRRSRR.-AAh.RSPYSS....oEPLC......SP.p...ESDSDLEPVGuGIQ+LQKLSQcLD-AIhsEEptph.s.............................	0	1	2	6
+7155	PF07327	Neuroparsin		Neuroparsin	Moxon SJ	anon	Pfam-B_19487 (release 10.0)	Family	This family consists of several locust specific neuroparsin proteins. Neuroparsins are produced by the A1 type of protocerebral median neurosecretory cells of the PI-CC system and display pleiotropic activities: inhibition of the effect of juvenile hormone, stimulation of fluid reabsorption of isolated recta, induction of an increase in hemolymph lipid and trehalose levels, and neurotrophic effects [1].	21.40	21.40	22.40	26.20	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.59	0.72	-3.79	4	14	2009-09-11 14:17:53	2003-09-16 11:54:31	6	1	11	0	5	23	0	102.50	37	87.08	CHANGED	MKPAAALAAATLLIAVILFHRAEANPISRSCEGANCVVDLTRCEYGEVTDFFGRKVCAKGPG-+Css....atpCGsGhcCpsthCoGCSl+TLQCa.h-uhs.Spp	.........................................hhhlhhhlhLh.pps.tt..p....Rpsc..sstCs...s...Dh.s+CcYG..Vp.DhCGpcsCAKGPG-+CGG.....phaGhCG-GLhC.sCs..+CsGCSlcolpCa...........................	0	2	3	5
+7156	PF07328	VirD1		T-DNA border endonuclease VirD1	Moxon SJ	anon	Pfam-B_19558 (release 10.0)	Family	This family consists of several T-DNA border endonuclease VirD1 proteins which appear to be found exclusively in Agrobacterium species. Agrobacterium, a plant pathogen, is capable to stably transform the plant cell with a segment of its own DNA called T-DNA (transferred DNA). This process depends, among others, on the specialised bacterial virulence proteins VirD1 and VirD2 that excise the T-DNA from its adjacent sequences. VirD1 is thought to interact with VirD2 in this process [1].	20.30	20.30	20.90	48.20	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-4.40	2	14	2009-01-15 18:05:59	2003-09-16 11:58:56	6	1	8	0	5	13	1	144.40	61	98.06	CHANGED	MSptoRsTSS-hAlNQ+cslpVEGFKVVSsRLRSAEYEoFSaQARLLGLSDSMAIRVAVRRIGGFLEIDAcTRc+MEAILQSIGhLSSNluhLLSAYAEsPp.DLEAlRsERIAFGcuFAsLDGLLRSILSVSRRRIDGCSLLKsAL	........MSpts+sTSSDh.lsp+cuspl...EGFKVVSsRLRSAEYEoFScQARLLGLSDSMAIRVAVRRIGGFLEIDA-TRpcMEAILpSIGsLSoNIusLLsAYAEsPpsDLEAlpAERhAFGcuFAcLDGLLRSILSVSRRRIDGCShL+-AL..	1	1	4	4
+7158	PF07330	DUF1467		Protein of unknown function (DUF1467)	Moxon SJ	anon	Pfam-B_19588 (release 10.0)	Family	This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.	23.00	23.00	23.40	33.30	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.86	0.72	-4.20	55	237	2009-09-11 13:34:12	2003-09-16 12:52:07	7	1	236	0	85	195	673	83.90	36	91.74	CHANGED	MulsoulslYhllWahshFslLPhtl.+oQsEs.ucll.....sGTcsGAPsphpht+KslhTTllusllaulhhhlhhsGhlolccls....phh	.....MslhoulAlYhllWWhsLFslLPhGl.RTQsEp.s-ls......GTssuAPsps+ltRthlhTTllusllaslhhhlhhsuhlslccls...h.........	0	22	51	62
+7159	PF07331	TctB	DUF1468;	Tripartite tricarboxylate transporter TctB family	Moxon SJ	anon	Pfam-B_19347 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. This family was formerly known as DUF1468.	27.00	27.00	27.00	27.20	26.90	26.70	hmmbuild  --amino -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.82	0.71	-4.53	199	1745	2009-10-20 16:26:54	2003-09-16 13:02:42	6	4	965	0	571	1522	1240	141.90	21	86.17	CHANGED	tt-hhsullh..hslGhhhhhtu.hshshssst.....thGPuhFPhhluhlLhllGhhlhlpuhht.............................ttstthhsths........h+........slhhllsul..lhaslll....................p..........slGhllush............lhh.hhsshshs.........pt....phhtsl...llul......slsshs..ahlF...shhLslsL.P	........................................................................t..phhhuh.l.h...lhlu.hh.hh.htu....hph....ththsh........shG.Pt.h.aPh.hluslh.hl.h....ul.h.ll.lp.shh............................................tpssshhtp.hs...................h.p..............p.l.hhhl...shh......lhas.h.h.h....................p.........hlG..Fhluos................lhh.hsh.h.h.h.hu......................tp..........ph.hhsh.....lhuh....shslhh...ahlF...sthLslsLP...........	0	158	355	476
+7160	PF07332	DUF1469		Protein of unknown function (DUF1469)	Moxon SJ, Finn RD, Sammut SJ, Bateman A	anon	Pfam-B_19352 (release 10.0) & COG5393	Domain	This family consists of several hypothetical bacterial proteins of around 140 residues in length. The function of this family is unknown.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.46	0.71	-4.38	97	1760	2009-01-15 18:05:59	2003-09-16 13:06:22	6	4	1530	0	487	1143	145	115.40	24	80.40	CHANGED	lspLlschssplspLlcsElcLA+sElpccsppsutusuhlsuAullshhulhhLhhslshuL..shh...........s.h...hAhLl....VuslhhllAullshhGhpclc...tshsPpcThcplccDhphlcpp	.................................h....hpclss.hsphlcsclcLAtsE...lpc...cttp.hhp...hlhhhuhshlhuhhuLhs....L.hhhl.h.h.ul..phh..h....................sAhlh.ssslhlll.Ahlhulhshpp.h+...psph.ppThcpltpDhphlct.t...........................................	0	139	307	413
+7161	PF07333	SLR1-BP		S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP)	Moxon SJ	anon	Pfam-B_19392 (release 10.0)	Family	This family consists of a number of cysteine rich SLR1 binding pollen coat like proteins. Adhesion of pollen grains to the stigmatic surface is a critical step during sexual reproduction in plants. In Brassica, S locus-related glycoprotein 1 (SLR1), a stigma-specific protein belonging to the S gene family of proteins, has been shown to be involved in this step. SLR1-BP specifically binds SLR1 with high affinity. The SLR1-BP gene is specifically expressed in pollen at late stages of development and is a member of the class A pollen coat protein (PCP) family, which includes PCP-A1, an SLG (S locus glycoprotein)-binding protein [1].	22.70	22.70	22.80	22.90	22.60	22.60	hmmbuild  --amino -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.59	0.72	-3.74	37	134	2012-10-01 23:31:40	2003-09-16 13:35:05	7	1	17	0	112	138	0	55.50	27	69.59	CHANGED	sppppupp.....Cpphl.........sspCssspCpshChpp....h+Gs...GpChs........ttphtChCtY.C	........t.....ttth....Cpphl.........sssCs..hspCpstCtpc....apGs...GpChs...............ttthpChCpY.C.......	0	43	57	62
+7162	PF07334	IFP_35_N		Interferon-induced 35 kDa protein (IFP 35) N-terminus	Vella Briffa B	anon	Pfam-B_17864 (release 10.0)	Family	This family represents the N-terminus of interferon-induced 35 kDa protein (IFP 35) (approximately 80 residues long), which contains a leucine zipper motif in an alpha helical configuration [1]. This family also includes N-myc-interactor (Nmi), a homologous interferon-induced protein.	22.90	22.90	23.00	25.10	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.45	0.72	-4.01	6	78	2009-01-15 18:05:59	2003-09-16 13:47:53	8	3	29	0	36	73	0	71.60	41	25.89	CHANGED	LltEIpcENhpLKcEIQKLEsELQpssRE.QI+EDlPcsKlKFoSsEsP....EsssQhuslSpShQss.KlsYELQKGQ	.........lptlpcEphpLKpclQ........ELQp....tp+...-..l+c......DlP..csKlpFsssEsP....tpspQhpslupShpsss+lsY.LpcGp.....	0	2	3	9
+7163	PF07335	Glyco_hydro_75	Chitosanase;	Fungal chitosanase of glycosyl hydrolase group 75	Moxon SJ	anon	Pfam-B_19431 (release 10.0)	Family	This family consists of several fungal chitosanase proteins. Chitin, xylan, 6-O-sulphated chitosan and O-carboxymethyl chitin are indigestible by chitosanase [1]. EC:3.2.1.132. The mechanism is likely to be inverting, and the probable catalytic neutrophile base is Asp, with the probable catalytic proton donor being Glu. (see the Chitosanase web-page from CAZY).	21.00	21.00	29.00	26.50	20.80	20.50	hmmbuild  --amino -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.23	0.71	-4.34	43	185	2009-01-15 18:05:59	2003-09-16 13:51:45	6	12	121	0	107	196	0	160.70	34	51.35	CHANGED	MDlDCDGss........................hpC................p..sss.shQspTuFp...............................................h....shpsLsApthPYlVls................sshas.pspG..lpstslsAVls..ss+lhYGlhGDo..........sus....shlGEASlulAcsh..sp.......shsGssG..psss...DVh.......................Y.................IsFsGsc..ss.Pstth....spshpshppsl..pshG-cLlspl	.......................................................................................MDlDCDGts........................................................sspC....................................s..sss.shQspTuFp...................................................t.shpsLsAshhPYVVhss...................sshasspptG..lcshSVsAVVs....ss+l.............hYGl..hGDT..........NGs.............shhGEASluhApsC.....sp.........sh.sGssG.....psss....DVl.......................Y...................IsFsGsc...uV.Putst....spshtp.tpol..tthGsphlt..h.................................................................	0	19	51	85
+7164	PF07336	DUF1470		Protein of unknown function (DUF1470)	Moxon SJ	anon	Pfam-B_19432 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 180 residues in length. Members of this family are found in Streptomyces, Rhizobium, Ralstonia, Agrobacterium and Bradyrhizobium species. The function of this family is unknown.	23.40	23.40	23.40	23.50	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.68	0.71	-3.82	101	865	2009-01-15 18:05:59	2003-09-16 13:55:16	6	4	373	1	337	872	14	127.80	18	66.25	CHANGED	usphuLDhlNTsshts.......stsh-tLsss..ssltsWlttpshhsssssstttt...............httst...sLR-...slpplhput...tsspt...........slstlNphltpss.stspLst........t..ththphttsssss..tshlss...lAt.shspllsssph	...............................................phsl-hlNThh..h.t...........tt.hDhLsss........pslttWh.....p....tt..s.hsss..ttssttth..................................................tth+.......plR-...slctlhput..........sstt.................slsh.lNphltpss..stsplst......................ht.ht.....h.h.ssss..sh...........sth..lus...lAt..shhpllst...h........................................	0	130	251	303
+7165	PF07337	CagY_M		DC-EC Repeat	Yeats C	anon	Yeats C	Repeat	This repeat is found in the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells ([1]). It forms part of a surface needle structure, and this repeat may form an alpha-helical rod structure ([1]). A conserved -DC- and -EC- can be seen in regularly spaced in the alignment.	20.70	20.70	21.50	20.70	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.49	0.72	-4.46	13	2220	2009-01-15 18:05:59	2003-09-16 13:58:32	6	49	41	0	30	2236	1	32.50	51	48.99	CHANGED	+AahDClspA+sEpE+p...EC.KLLocpt+chLpc	..+AYhDClspA+sEpE++...EC.KLLosEt+KhLpt.........	0	29	30	30
+7166	PF07338	DUF1471		Protein of unknown function (DUF1471)	Moxon SJ	anon	Pfam-B_19452 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some members of this family are annotated as ydgH precursors and contain two copies of this region, one at the N-terminus and the other at the C-terminus. The function of this family is unknown.	21.40	21.40	21.70	21.90	21.30	21.00	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.39	0.72	-4.32	81	6384	2009-01-15 18:05:59	2003-09-16 14:09:38	8	3	551	5	450	1630	15	55.80	31	59.41	CHANGED	slpshGslossut....so.s-lpptluc+A-ppGAphYhIhptps....ssphcuoAtlY+	..............hp.hG.slSsout....uo.s-hcptluc+AccpGAssYpIsphpp.......sss.....hcuoA.lYK..........	1	15	79	263
+7167	PF07339	DUF1472		Protein of unknown function (DUF1472)	Moxon SJ	anon	Pfam-B_19493 (release 10.0)	Family	This family consists of several Enterobacterial proteins of around 125 residues in length and contains 6 highly conserved cysteine residues. The function of this family is unknown.	19.60	19.60	19.90	20.30	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.56	0.72	-3.70	2	74	2009-01-15 18:05:59	2003-09-16 14:16:46	7	3	48	0	0	59	0	78.20	61	47.89	CHANGED	AWPCGFSshWP.pRVRAVPCLHLSRAGtDARVRFAAAVTRSLLPVCRDFPVVHPLRFRGLTLQLPsAVCVRLRLPLRPVHPRLIARLLWRHGTARCRthC-	.....................................AWPCGFSVMWP.pRVRAVPCLHLSRAGhDARVRFAAAVTRSLLPVCR..DFPVV+PLRFRGLTLQLPsAVCVRLRLPLR.....PhhP.tL...........................................	0	0	0	0
+7168	PF07340	Herpes_IE1		Cytomegalovirus IE1 protein	Bateman A	anon	Pfam-B_22587 (release 10.0)	Family	Expression from a human cytomegalovirus early promoter (E1.7) has been shown to be activated in trans by the IE2 gene product. Although the IE1 gene product alone had no effect on this early viral promoter, maximal early promoter activity was detected when both IE1 and IE2 gene products were present [1].  The IE1 protein from cytomegalovirus is also known as UL123.	19.60	19.60	19.60	19.60	19.30	18.60	hmmbuild  -o /dev/null HMM SEED	392	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.20	0.70	-6.02	2	150	2009-01-15 18:05:59	2003-09-16 14:24:06	6	2	14	0	0	143	0	212.90	60	59.56	CHANGED	MESSu.KRKMDssNPDEGPSSKlPRPETPVoKAssFLpoMlpKEVNSQLsLGDPLFP-luE-sLKoFEcVTc-CsENPtKDlLtELVKQIKVRVDhVRp+lKpHMLpKYTQh-EKFTuAFN.MGGCLQsALDILDKVpEPFE-MKCIGlTMQsMYENYlVsE-pR-hWhtClK-LHDVuKsAAsKLGsALpAKApAKK-ELpRKMhYhsh+plEFFTKNSAFPKTTNGsStAhAALQsh.QCSP-ElhsaAQ+IhKhLDEERDKVLhHIDpIFMDILTTCVETMsNEYKVTSDAsMMTMYGuISLLoEFCRVLSCYlLEEoSVMlA+pP.ITK.-llSsMpRRIpEICM+VFAQYlLGsDPLRVCSPSV-DLRAIAEESDE-EAIsAashAT	.................................ssPt.GsS.s........K.s+.-s..h..p.pAstaLpphLttEhp..s.lsLGDPLF...s.hs.pp..hcohEplhppt.pss..........................................................................TMQsMYENYIVPEDK..REMWMACIKELasVoKGAANKLGGALpAKARAKKDELcRKMhYMCYRNlEFFTKNSAFPKTTNGCSQAMAALQNLPQ.C.S.P.DEIMs...........................................................................................................................................................................................	2	0	0	0
+7169	PF07341	DUF1473		Protein of unknown function (DUF1473)	Moxon SJ	anon	Pfam-B_19856 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be found exclusively in Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	25.00	25.00	38.10	38.00	21.20	18.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.99	0.71	-4.69	2	128	2009-01-15 18:05:59	2003-09-16 14:28:22	6	1	27	0	8	89	0	145.10	72	98.82	CHANGED	MRYKhKILT+sKTacYsLKslPhYEWDpVLGF.sppDt.l.KLN-lphL+EITpLMIS.tFLDEFY.ILsppRca.phYK.hLshIlahsQashFph.pshKKPuLVYlppapspsGDalpaDYIsEpapY-hlhTS.pS.s.Np............pEhVsc	...MRYKMKILTKNKTYEYPL+VLPVYEWD+VLGF.NQSDA.lhKLNEVKYLREITSLMISPKFLDEFYlI.LDpNREFISYYKDYLVAIIYTAQFNTFHlDNDLKKPALVYLSEYENNVGDFVsFDYIN.ENF-YEKVsTSLoSso.NSp-................Lhsh.........	0	5	5	5
+7170	PF07342	DUF1474		Protein of unknown function (DUF1474)	Moxon SJ	anon	Pfam-B_19882 (release 10.0)	Family	This family consists of several bacterial proteins of around 100 residues in length. Members of this family seem to be found exclusively in Staphylococcus aureus. The function of this family is unknown.	21.40	21.40	21.50	56.10	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.40	0.72	-3.78	5	167	2009-01-15 18:05:59	2003-09-16 15:10:26	6	1	114	0	3	77	1	96.30	55	95.33	CHANGED	MNWEIKNLhsDLEVLKEKFEDLKDsHGWHFEEhYsHEPNHsLNKDEhI+EGsSYHERRIHN-QMhDLhHlYhcpFDcIlcKFcEIEKASS-.sFG-cSDDA	.MNWEIKsLMCDlEllK-KlpDlsspHuWFsE-hFs...Ncl.oKcEhIsauhSYhEHRIpN-phh-LhplYLK-FspLIpKF+EIEKASS-..sFu-.SDDA................	0	0	0	3
+7171	PF07343	DUF1475		Protein of unknown function (DUF1475)	Moxon SJ	anon	Pfam-B_19887 (release 10.0)	Family	This family consists of several hypothetical plant proteins of around 250 residues in length. Members of this family seem to be found exclusively in Arabidopsis thaliana. The function of this family is unknown.	21.10	21.10	21.50	21.20	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.06	0.70	-5.03	2	48	2009-01-15 18:05:59	2003-09-16 15:13:07	6	2	25	0	21	46	101	187.80	39	93.19	CHANGED	MAssu.lssh+sVhsshhsLMLuTLVYThlTDG.Ph..R.-lhTPWhVsTllDFYlNlssIusWllYKEssW.uShhWslLLhhFGSlsTCsYlhlpLhclpsptsSpDPh.hLhLR....pGsh.ccKsShVlhuRhlFuhLGshMhusllYTshT.G.PF+h-LLhPWMsshLlsFYIsVhslSVWVsaKESshI.shlWlsLLIshGSlsTsuhIVlQLFplS.hDPlYhVL...Lps+sK.lNu..Gph.	........................................................h.hh+slhsshhhlMlu.sLlYThhT...DG.Ph..R.-lh..T..PWhssTllDFYlNlhslusWlhYKEssa.uuhhWhlhLhhhGShsTssYlh.phhclpsttsspsPh.hlhlR....pss..ppKp...VhhuRhlFuhLGhlMhuslsYTsh..TsG.PF+...h-.....LL..sPWMssoLlDFYIsVhslSVWVsaKESohIsshlWlsLLIshGSlsTsuY.IllQLhplS.tDPlhhVL....................tt.....................	1	9	15	18
+7172	PF07344	Amastin		Amastin surface glycoprotein	Vella Briffa B	anon	Pfam-B_19245 (release 10.0)	Family	This family contains the eukaryotic surface glycoprotein amastin (approximately 180 residues long).In Trypanosoma cruzi, amastin is particularly abundant during the amastigote stage.	23.60	23.60	23.80	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.28	0.71	-4.61	76	430	2012-10-03 00:20:40	2003-09-16 15:13:54	6	2	19	0	67	443	0	156.20	30	75.97	CHANGED	FlAFl........hVLVuT.PlDM..F.Rhpst.......s..psClTLWG..hKpsCpsspYshpssth.atsC....ssRhppF+sApAFAlISIhlauAAhlhGhl....hLhCC..............................................shhRhlCLsLNllGslTlslVWAsMsssYth........-sthC.s..thp..................pth.paGu..................GFuLhlsAWlL-llNIlhL	..............................................hlAFlFVlluT.Pls........F.+sctp.........ss........psClTLWG........hK........pcC.p.s.sp.Y..phshsph.at......pC........s..shhphFRh..ApAFuIISIhlhhuAhlhGhh.....hhh.s.h..............................................psh+..h..hs..hh...LslluhlTs..slVWssMsshYp.............ss.C.s.......thp..........................pth.paGs....................GFsLhVhu...WsLphlshhh.....................................................	0	54	59	67
+7173	PF07345	DUF1476		Domain of unknown function (DUF1476)	Moxon SJ	anon	Pfam-B_19680 (release 10.0)	Domain	This family consists of several hypothetical bacterial proteins of around 100 residues in length. Members of this family are found in Bradyrhizobium, Rhizobium, Brucella and Caulobacter species. The function of this family is unknown.	25.00	25.00	25.70	25.60	23.20	22.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.29	0.72	-3.78	53	246	2009-01-15 18:05:59	2003-09-16 15:17:52	6	2	219	2	87	209	311	101.80	49	93.76	CHANGED	M.ToFDDREcAFEsKFAHDpEhpFKApARRNKLLGLWAA-hLGhoGs-A-AYAppVVpADFEEuGD-DVhRKltuDLss.tuht.s-spIRs+MschhspA.ctQl	........................M.TshDDREcAFEpKFAhDpEhcFKAcARRNKLLGLWAA.Ep.LGhsss-A.-AYA+-VVtADFEE....AG....DEDVhRKVpuDLsu.tGlsho-ppIRt+MtphhtpAhpQl..............	0	28	56	65
+7174	PF07346	DUF1477		Protein of unknown function (DUF1477)	Moxon SJ	anon	Pfam-B_19762 (release 10.0)	Family	This family consists of several hypothetical Nucleopolyhedrovirus proteins of around 100 resides in length. The function of this family is unknown.	21.60	21.60	84.20	83.90	21.20	19.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.71	0.71	-4.06	19	41	2009-01-15 18:05:59	2003-09-16 15:20:19	6	1	40	0	0	37	0	112.00	31	96.21	CHANGED	M.......................pt.t.phpsutsp...........sltshss......su+phFYphshs....alpph.sssphshsTltslhDtIIphEpslFs+ShVLNhllsFLlspSDGss.lQstl.splLsaLLpKYh	...................h...........th.pstsp...........slsslhs.....psu+phFYplshu....alpphh.hsspssl.TlpshhDtIIphEcslFs+ShlLNhlVsFLlspSDGss.lQstl.splLsaLLpKY................	0	0	0	0
+7175	PF07347	CI-B14_5a		NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)	Vella Briffa B	anon	Pfam-B_19436 (release 10.0)	Family	This family contains the eukaryotic NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) (EC:1.6.5.3). This is approximately 100 residues long, and forms part of a multiprotein complex that resides on the inner mitochondrial membrane. The main function of the complex is the transport of electrons from NADH to ubiquinone, accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space [1].	25.00	25.00	27.60	27.30	19.70	17.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.30	0.72	-4.22	9	115	2009-09-11 15:22:33	2003-09-16 15:42:13	7	1	89	0	77	113	0	95.00	41	80.28	CHANGED	o.hlQ+lRsFLLGR..caphsLRapDtlucRTQPsPpLPcGPuHKLSuNYYspRDuRREVsPPlsl.hpspKtLhAtpsuuht......p+hssPG.psasW-	...........o.hlpplRsah.G+...ptph..tLRap-..lupR..TQPPPpLPsGPuH..KLSsNYYhTRDuRREshPPhll..hss...p.Kt.Ls..us...ps....s.....tp..tss...s...p+ssoPu..hhtW..........................................	0	25	31	55
+7176	PF07348	Syd		Syd protein (SUKH-2)	Vella Briffa B, Zhang D, Aravind L	anon	Pfam-B_19909 (release 10.0)	Family	This family contains a number of bacterial Syd proteins approximately 180 residues long. It has been suggested that Syd is loosely associated with the cytoplasmic surface of the cytoplasmic membrane, and that interaction with SecY may be involved in this membrane association [1]. Operon analysis showed that Syd protein may function as immunity protein in bacterial toxin systems [2].	25.00	25.00	26.00	25.50	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.71	0.71	-4.94	43	745	2012-10-01 20:46:44	2003-09-16 16:03:31	7	2	729	2	81	305	25	173.90	60	95.43	CHANGED	lppALpsFhppYhptappppuphPtsth..s....hsSPCl...........psp-stlhWpPl..........+s.sschsslEcAL-lpLHssIpsFasshauuchtupap......stplpLLQlWsc-DFp+LQcNllGHLlMp++LKpssTlFIussss.-tpllolsNhoGpVhLEphGppp+chLAssLspFLspLpP	.......T.AQAL+sFTsRYCDAWpEcHtSaPlSEELYG....VPSPCIl..........uoo-DAVaWQPQ.........PF.s.u.E.pNlNAVERAhDIslQPsIHsFYTT....QFAGD.MpAQFu......Dh+LTLLQsWSEDDFcRVQENLIGHLVTQKRLKLsPTLFIAThEp.EL-VISVCNLSGEVhpETL.......GT+pRThLAusLAEFLsQLcP..........	0	9	25	51
+7177	PF07349	DUF1478		Protein of unknown function (DUF1478)	Moxon SJ	anon	Pfam-B_20105 (release 10.0)	Family	This family consists of several hypothetical Sapovirus proteins of around 165 residues in length. The function of this family is unknown.	25.00	25.00	25.10	25.10	20.20	18.40	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-10.94	0.71	-4.86	9	46	2009-01-15 18:05:59	2003-09-16 16:04:07	6	2	46	0	0	37	0	144.80	55	98.42	CHANGED	MA.Ps.pspcplsth.hhLT......RLspLsRPHPhLLhLIRNNPMGP+sAW+WLL.LsQSN.MSLpQYuTALQShVLLLGhhsCPRELhhDLa+FIPTLh+Th.IsptCG.uGsssLRssapSLuLssLLusSLLLShHpGLh.R.SshpsCCLTLpLMLA.hsQFh.	.........................MAPs.pspphhsth.hhLT......RLAQhlRPHPhLLhLIRsNPMGPHsAWpWLL.LVQSN.MSL+QYATALQSFVLLLGTTsCPRELh.hDLaRFIPTLT+T.hhshtCG.GGsssLRsshpSLsLushLusSLLLS...thh...ssh.....h...........................	0	0	0	0
+7178	PF07350	DUF1479		Protein of unknown function (DUF1479)	Moxon SJ	anon	Pfam-B_20226 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins, of around 420 residues in length. Members of this family are often known as YbiU. The function of this family is unknown.	19.60	19.60	19.70	19.80	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	416	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.38	0.70	-5.99	29	709	2012-10-10 13:59:34	2003-09-16 16:07:15	7	6	609	3	194	467	337	392.90	54	91.46	CHANGED	ssL.Ps....papplKppLh...sp.....ctlhtoWc+lltslpcclcplpptGss..slPplsFsDItssphs........sphttpl+cRGssVIRuVhsccpAhpWpp-ltcYlcpN...........sp.htshs..sscPplYplYWSpsQlcARtHPphhtsppFhs.pLWp........st..sspshhshcpslsYADRlRhR.PGss.........................................................................phuLusHlDuGSlERWp-csY..pplYcplFc..GcWE.caDPa-A...spRssupppha.......tususCShFRoFQGWhALSshtPspGTLplhPlsc.uhAYhlLRPhFssss........................................................................sschsGAhPGpu.phssph.HPcLpL.cshlsIPclpsGDhVaWHCDllHuV-stHpGpssSsV......................hYIPusPhstpNstYltcQRcuFlpGpsPPDFstts.................EssatGRss.pc..lsph.....GhpuhGl	............................c....AAIRphKpuLRAplG.D....sQtlFspLscsIAspVsE...Issl...+ApGps...................VhPhlsauDI..t.sGp.lo........spp+tpIKRRGCAVI+GhFPREQALu..WcpshlDYLD+N+FDEh...............h+ustDs.aFGoLu..AS+PpIYslYWSpAQhpARQSccM.s.t.AQsFLN.R.LWp..................hE...pDGKpa.........FsPDhsllYsDRIRR.RPP.GoT.........................................................................SpGLGAHsDSG.uLERWLhPuY...p+VassVFs...Gs..hp....p............YDPWcA...AHRT-VEEash...............csospCSVFRTFQ..................GWTALSD....h.hP........G......pGhLHVlPIPc..AM.AYlLLRP...LhDDVP.........................................................................-D-LCGsAPG....Rs....L....sl....SE.p....W..HPL..Lh.cALoSIPpLEAGDoVWWHCD................VIH....S.Vs......sVc.NtpG.auNV.........................................................MYIPAA.PhCEK.NlAYs++.+sAhpcGsSPsDFPp-D....a.............EosacGRh.TltD..Lshc.....GKRALGh...............................................	0	48	99	165
+7179	PF07351	DUF1480		Protein of unknown function (DUF1480)	Moxon SJ	anon	Pfam-B_20253 (release 10.0)	Family	This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.	25.00	25.00	43.00	42.80	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.65	0.72	-3.99	6	520	2009-09-11 08:41:35	2003-09-16 16:08:45	8	2	509	0	27	99	0	76.60	83	99.24	CHANGED	MsKTsV+IuuFEVDDApLSSss.cs.-pTlSIPCKSDPDLCMQLDGWDEpTSIPAlLDGKcpLLY+pHYD+ppDAWVMRls	.........KTSVRIGAFEIDDuELHGES.PG..-RTLTIPCKSD...PDLCMQLDAWDAETSIPAlLNGEHSVLYRT+YDQQSDAWIMRL.A...	0	1	6	17
+7180	PF07352	Phage_Mu_Gam		Bacteriophage Mu Gam like protein	Moxon SJ	anon	Pfam-B_19455 (release 10.0)	Family	This family consists of bacterial and phage Gam proteins. The gam gene of bacteriophage Mu encodes a protein which protects linear double stranded DNA from exonuclease degradation in vitro and in vivo [1].	24.70	24.70	25.20	28.10	23.90	24.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.71	0.71	-4.68	27	345	2009-01-15 18:05:59	2003-09-16 16:14:02	7	1	306	2	48	280	5	146.00	27	85.80	CHANGED	sh-plshsl+clu-lppchpclcsthscclscIc-thpsph...........cslpsclphlpptlpsascsp+sEhs...ctKohphshGplpaRtppsssth....sh-sllctL.+ph....Gh.pca...........I+scE-lsKcslhppsc.............sspslsGlplppt.-sFtlcs	..................................sh-plshsl+clu-lppcht+lps.......th.......scplscIpcphssph...........csLppclchlppslpsascsp+cEhs...........cpKohshshGclsaRhpssssph.p......sh-sllchL.+ph...........GL...pca............I+s.KE..ElsK-Alhpp.c..............sstslsG.lplhpt.-sFhlcs...................................................................................	0	27	44	47
+7181	PF07353	Uroplakin_II		Uroplakin II	Vella Briffa B	anon	Pfam-B_19993 (release 10.0)	Family	This family contains uroplakin II, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension [1].	20.40	21.30	20.40	21.30	19.30	21.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.31	0.71	-4.94	4	38	2009-01-15 18:05:59	2003-09-16 16:33:11	7	1	28	0	18	34	0	160.30	65	91.72	CHANGED	MASsLPVpTLPLILILLAVLuPGAA.DFNISSLSGLLSPALTESLLVALPPCHLTGGNATLMVRRANDSKVV+SSFVVPPCRGRRELVSVVDSGSGFTVTRLSAYQVTNLsPGTKYYISYLVpKGsSTESSREIPMSTLPR+NMESIGLGMARTGGMVVITVLLSVAMFLLVlGhIlALALGARK	..................................Mss.hPl.TLP.hhLlLLslLuPGuA....-FNISSL...SGLLSPALTESLLVALPPCHLTGGNATLhVRR..ANDSKVVpSuFVVPPCRGRRELVSVVDSGuGFTVTRLSAYQVTNLsPGTKYYlSYhVpKG...suTESSp....ElsMSTLPR+phEoIsL.GM.ARTGGMVVITVLLSVAMFLLVlGhIlALALGs+K..................................................	0	1	2	4
+7182	PF07354	Sp38		Zona-pellucida-binding protein (Sp38)	Vella Briffa B	anon	Pfam-B_19996 (release 10.0)	Family	This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90-kDa family of zona pellucida glycoproteins in a calcium-dependent manner [1]. These represent some of the specific molecules that mediate the first steps of gamete interaction, allowing fertilisation to occur [2].	21.20	21.20	21.20	23.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-11.82	0.70	-5.75	5	94	2009-01-15 18:05:59	2003-09-16 16:59:07	7	5	32	0	42	97	0	231.60	49	65.01	CHANGED	MDh+LuscElVDPsYpWpGPsG+sLoGNSplNITsTGpLlLpcFpESLSGlYTCTLSYKllcApTQEEssl+cpY+FhVYAYREPcYsYQhoVRFTA+uCsutYNssFhRtLKKIL-sLISDLSCcVptPSY+CHSVKhP++GL.sELFlsFQVNPFAPGWcshCsu.StDCEDoTN+plpKA+DRIE-FFRpQsYIL+HpFps.LPsIHYVEGSLQVVhIDsCRPGFG+NplpHssCAuCCVVCSPGTYSPDsuloCpsCsSuLl..YGAKoCP	.............hs.cLpppEllDPoa.WhGPptKhlo........tNsphpITpTGp.LhhpsF.EshSGlYTChLpYKs....T.EEhhhphphcah..laAYREPcY.YQhssRapst.sCtuhaN..F.+hLhpILspLl.DLSCcl...p.cCH.pVch.+tGL.pELFhsF..pVs.shssthtst.sst.shsCE....s.pp..l.p.A+shIEcFFppQs.....lht+php...lPthaal-t...ohQhVhlspChPGaGhN.hhHspCspCC.VlCSPuoasPcsslpC.pCs..osh...h..YGAKsC............	0	4	5	12
+7183	PF07355	GRDB		Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	Vella Briffa B	anon	Pfam-B_19711 (release 10.0)	Family	This family represents a conserved region approximately 350 residues long within the selenoprotein B component of the bacterial glycine, sarcosine and betaine reductase complexes.	19.40	19.40	20.00	19.70	19.20	19.30	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.07	0.70	-5.52	12	440	2009-01-15 18:05:59	2003-09-16 17:22:43	7	2	262	0	72	365	148	241.10	30	90.78	CHANGED	Mt.hKlVHYINQFFAGlGGE-KADhtPclt-u..sGsuhtLsthlcscAElltTVICGDSYas..ENh-cAppplLchlcphpPDlhlAGPAFNAGRYGsACGsIsKhVp-cLsIPulTuMYhENPGs-haKKslYllpTusSAAuMRculPthAcLAhKlhKGE.cIGsPpcEGYhsRGIRhNaFtE-R..GucRAV-MLlKKLpGEpFpTEaPMPsFDRVsPssAl+DlSKAKIALVTSGGIVPKGNPD+IESSSAS+YGcYDIsGhccLostsaETAHGGYDPsaANtDPsRVlPVDVLR-hEKEGhIGcLHchFYoTVGNGTuVAsuKpaupEhstcLhpsGVDAVILTST	...................................................................+hlhhlsp..uthGu--pAph..thcpt..hGsuh.h....h.t.t.....hclhsTlhCGDpah...pp.-p.s.tphhthhpphpsDhhlsGPuhphspaG.hsutlst...pthslPsl..suM..E.N.s.u..h.phahp..p..h.Ilp.h.tps.uhshppsh.thst.hs.thhp.tc.thh.....................................................................h..t.htphplAlhTsuG.l.h.....h.t...t.......cp.....s.st.pat.h.h.......t..............t.ph.s.Hu..GaD.s.s.s.tD.shhhPlDhh+chtpcGhI.ttlh.hah..shh.Gs..G.s.s.....t.p.t.p.ph.u.tlst.LhtttVDuVlhsu..............	0	38	58	65
+7184	PF07356	DUF1481		Protein of unknown function (DUF1481)	Moxon SJ	anon	Pfam-B_20042 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 230 residues in length. Members of this family are often referred to as YjaH and are found in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.	25.00	25.00	25.80	25.30	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.25	0.71	-4.85	17	658	2009-01-15 18:05:59	2003-09-17 11:01:20	7	3	648	0	52	244	1	185.70	59	83.59	CHANGED	uuGhstscusshhWhp-ctsps..thhusasshtssuphpocYRWppspL+plpRps.......stsP.pl+lRFspcG-ssa.QhclsGch..LosDQlshYphcAcpllptocsLcpsplhLhQG+Wp..spolpTCpG.phhp.-h-pph.sal.pR...uohcs.lAaLtuscs........ppLLLlsss-a.ChhpPp	...................ASGFAtDpGAVRIWRKDosDpV..HLLuVFSPW+SG.sTTTpEYRWQGDsLoLIplNlY......SKPPhsIRARFDc+G-LSFMQREssGcKQQLSNDQIsLYRYRA-QIRQhSDALRpGRVlLRQGRWH.h-pTVTTCEG.pTlKPDLDSpAIuHIERRQs+SSV-VSVAWLEAPEG........SQLLLVANSDF.C+WQPp......	0	3	12	32
+7185	PF07357	DRAT		Dinitrogenase reductase ADP-ribosyltransferase (DRAT)	Moxon SJ	anon	Pfam-B_20108 (release 10.0)	Family	This family consists of several bacterial dinitrogenase reductase ADP-ribosyltransferase (DRAT) proteins. Members of this family seem to be specific to Rhodospirillum, Rhodobacter and Azospirillum species. Dinitrogenase reductase ADP-ribosyl transferase (DRAT) carries out the transfer of the ADP-ribose from NAD to the Arg-101 residue of one subunit of the dinitrogenase reductase homodimer, resulting in inactivation of that enzyme. Dinitrogenase reductase-activating glycohydrolase (DRAG) removes the ADP-ribose group attached to dinitrogenase reductase, thus restoring nitrogenase activity. The DRAT-DRAG system negatively regulates nitrogenase activity in response to exogenous NH4+ or energy limitation in the form of a shift to darkness or to anaerobic conditions [1].	25.00	25.00	69.20	41.30	21.50	16.00	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.73	0.70	-5.20	13	92	2009-01-15 18:05:59	2003-09-17 11:15:03	6	3	79	0	43	88	13	252.50	44	92.94	CHANGED	GHSTNLVGlPs-hLuSssFN-cP.hPLHIuGVREMNssLFEMLupApsLt-AG-AFhsYMsAhFGlDsEQptsc.....sssG+..RRFRuSaLRLL+GWGaDSNGsEGAVLKGWVESRFGLFPTFHKpsIs+huosuWtsYVEEKMuSRFHNNuIalQLDLLYEFCQWALsR....assPGc.oHlsLYRGVNsFcEHplltRlD+RpsVlRLNNLsSFSSDR-lAsCFGDpILTs+VPlsKVlFFNsLLPuaPLKGEGEYLVIGG-YRVssSh.l	.......thNhsslPshlluShtFNcpP...hsLcIsGVRchpssLFchLsttss.t-tupsFpcYMsshFsLt..p.pt.........stsuc...+Rh+..uSYLRLL+GWsaDSNusEGAVLKGWVESRFGLhPoFH+t.lsphsopAahpYhp-+hsupa+sNuI.sQLDLLYEaCQatltR.....th..Pup..pHlpLYRGsNchsEHpllt.....ch.scR.ptllRLNNLsSFoo-R-hAspFGDhlLcspVPlsKllFFssLLPs.hL+GEuEaLVIGGcYcVcht.h....	0	16	31	35
+7186	PF07358	DUF1482		Protein of unknown function (DUF1482)	Moxon SJ	anon	Pfam-B_20128 (release 10.0)	Family	This family consists of several Enterobacterial proteins of around 60 residues in length. The function of this family is unknown.	25.00	25.00	28.10	27.70	23.50	16.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.75	0.72	-4.38	12	929	2009-09-11 12:49:17	2003-09-17 11:20:43	6	1	454	0	29	221	0	57.20	57	86.88	CHANGED	hFALVLhVshlsGsspDlllulYsopppChsAtsEQ+lp.GsCaPl-chIc..s..hPAu	..hFALVLhVhhlsGtspDIlVs.VYsTcQpClhuhs-Q+Ip..GsCaPl-chIc...s...hPAt....	0	2	5	16
+7187	PF07359	LEAP-2		Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)	Moxon SJ	anon	Pfam-B_20235 (release 10.0)	Family	This family consists of several mammalian liver-expressed antimicrobial peptide 2 (LEAP-2) sequences. LEAP-2 is a cysteine-rich, and cationic protein. LEAP-2 contains a core structure with two disulfide bonds formed by cysteine residues in relative 1-3 and 2-4 positions. LEAP-2 is synthesised as a 77-residue precursor, which is predominantly expressed in the liver and highly conserved among mammals. The largest native LEAP-2 form of 40 amino acid residues is generated from the precursor at a putative cleavage site for a furin-like endoprotease. In contrast to smaller LEAP-2 variants, this peptide exhibits dose-dependent antimicrobial activity against selected microbial model organisms [1]. The exact function of this family is unclear.	21.20	21.20	24.50	23.20	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.85	0.72	-4.32	2	67	2009-01-15 18:05:59	2003-09-17 11:26:34	6	2	48	1	28	57	0	75.00	52	66.92	CHANGED	MhpLKLFAVLhhCLLLLuQVsuSPlPp.SSAKRp.RRMTPFWRuVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE	........................lhAhLh.lhLLLls.Ql.suS..P.l........P.......-...........l..........SS.........u.........+...RR.+...RMTPFWRuVSLRPlGASCRDsSEClT+LCR+t+CShs............................................	0	1	2	8
+7189	PF07361	Cytochrom_B562	Cytochrome_b562;	Cytochrome b562	Vella Briffa B	anon	Pfam-B_18074 (release 10.0)	Family	This family contains the bacterial cytochrome b562. This forms a four-helix bundle that non-covalently binds a single heme prosthetic group. [1].	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.37	0.72	-3.61	25	795	2009-01-15 18:05:59	2003-09-17 11:35:06	6	2	709	109	71	320	3	102.50	48	80.57	CHANGED	s-LcssMpphstshppstcAssspphcpulschcsts.cupptp.Pschcs....p.thpsYpcGhcpLlsplDpApthsppGcLc-AKpuhpclpslRpcYHcKa+	..........tDL--sM-sLscNh....Kll...p...K.A.DsAsplKsA...Lo+MRuA..AlDAQKus.PPKLEsK....usDSPE....M.KDFRHGFDlLlGQIDcALK.LAsEGclc.EAp...AAAcpLKsTRNsYHcKYR..............	0	6	22	46
+7190	PF07362	CcdA		Post-segregation antitoxin CcdA	Moxon SJ	anon	Pfam-B_20349 (release 10.0)	Family	This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein [1].	21.40	21.40	21.40	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.24	0.72	-4.11	25	640	2012-10-02 18:44:02	2003-09-17 11:44:48	7	4	509	9	114	324	32	67.90	35	86.53	CHANGED	sKKssNlolsu-LlppA+shsINlStslEpuLpcpl+c.......pcscpWpcENccAIcshNchl-ppGhFuD-aRpF	...................ppploVTl-s-LhppA+s....h....s..l.NlSuhlssulppEl+c........pt.s..c..R..W.p..t..E.Np..cu.httlsphh-tpG.auD-.Rsa.......................................	0	27	64	88
+7191	PF07363	DUF1484		Protein of unknown function (DUF1484)	Moxon SJ	anon	Pfam-B_20389 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 110 residues in length. Members of this family appear to be found exclusively in Ralstonia solanacearum. The function of this family is unknown.	21.20	21.20	23.10	22.40	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.32	0.72	-3.71	9	55	2009-01-15 18:05:59	2003-09-17 11:47:25	6	1	19	0	24	52	0	101.50	40	86.61	CHANGED	cpppuPQhLAhupp+pLlAQLApphuphs+RstsphAusltpLcssuppIccsTE-uCucLLsVSAGLtGILpLLDLpSDRus-scuLHCLLsPLKpQLDsALsclQcML	.................................t..p.sPphLAhsppppLhupLstpss..s++stt.httslpQLcssut.Ipposc-uCApLLsVSuGLsGILpLL-lpS-+uh.-.C+sLHCLLsPLKtpLDpALs-lQcML......	0	4	13	16
+7192	PF07364	DUF1485		Protein of unknown function (DUF1485)	Moxon SJ	anon	Pfam-B_20495 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 300 residues in length. Members of this family all appear to be in the Phylum Proteobacteria. The function of this family is unknown.	22.00	22.00	23.00	23.00	21.80	20.00	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.80	0.70	-5.22	60	567	2009-01-15 18:05:59	2003-09-17 11:50:56	7	6	358	1	215	587	505	283.50	31	58.09	CHANGED	MRlhlAultpETNTFuPs.oshssFp........thhpGsshhpshps.ssssluualchAct...............pGh.-ll....sslhAtApPuGhVscsAaEplps-ILssl+uu....hshDulhLsLHGAMVu-shDDsEG-LLpRlRsllGsclPlussLDLHuNlTppMlppADsllua+pYPHlDhhEsGpcsscllhchl..pGch+PshuhtchPhlhsh...hsTsppPh+shhcthtphEsc......llulSlhhGFshADhs-sGssllshu-.....DtstAcpsAcclupplashRscahs..phhsh-pulscAhs	........................................M+IhlAuhtpETNTFuPs..sshssFt.........httGsch...ht..t....ph....hssshsuhhchs.t.t..................................p.G.h..pll....sslhAtAtPuG....hVscpAaEplpscllstl...css....h..lDulhLsLHGAMls-sh-..Ds..EG-..LLpRlRtllGs....slPlusshDhHuNlotchlppsDllsua+paPHsDh.hEouc+....us.clL.hchL.......c.......u.......c......h.......+..........P.s.huhhclPhlhsh.t..hsTs.t-Ph.+uhhs....tlttlEtc..G...llusSl....hhGFs..h..AD..hPcsGssllls..ss..........Dt.stupthAccLupthhstRppath...shhshcpulspAh.t............................................	0	35	109	165
+7193	PF07365	Toxin_8		Alpha conotoxin precursor	Moxon SJ	anon	Pfam-B_20562 (release 10.0)	Family	This family consists of several alpha conotoxin precursor proteins from a number of Conus species. The alpha-conotoxins are small peptide neurotoxins from the venom of fish-hunting cone snails which block nicotinic acetylcholine receptors (nAChRs) [1]. 	21.60	21.60	21.60	22.80	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.86	0.72	-4.00	22	253	2009-01-15 18:05:59	2003-09-17 12:37:11	7	1	43	19	0	244	0	41.20	39	81.76	CHANGED	TTVVSFTSD.RASDGRNAAAppKsScLluhs.h+.tCCup......PsCtsppsthC.G	......................s....stpsAApp+sscLhshs..h..p..sC..Cup......PsCtssps.hC............	0	0	0	0
+7194	PF07366	SnoaL	DUF1486; 	SnoaL-like polyketide cyclase	Moxon SJ, Bateman A	anon	Pfam-B_20348 (release 10.0), Pfam-B_4335 (release 18.0)	Domain	This family includes SnoaL [1] a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486.  The proteins in this family adopt a distorted alpha-beta barrel fold [1].  Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation [1].	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.19	0.71	-4.55	29	1134	2012-10-03 02:27:23	2003-09-17 12:44:11	7	18	662	23	389	2430	1653	122.50	20	66.56	CHANGED	thhhphatshh....sptch....cthschlsschhtps........sshhGhcuhtthhpthhp.uhPDlph...plcphls-u.D+VssRhphpGoap.GthhG.....hss..oG+plphpthslh+lpc.GKIsEpWshhDhhulhpQL	...........................................................................t...hphh.thh....s...pt.ph.....s.h.h.s.p....h.h.s....s....c..h..h.......p...............................sth.G...h.....p..u...h.t....p.h.h........p.....t....h..h..p.....s.......h......P.....D....hph............pl..c..........p...h...l......s.........p.....u.....-........p..........V.....s......s.....+..h....p.....h.pG..oa.....p....G.....h....h....s....................h.s.s..oG+.plph...p...t.hsh..h+..h..c.s....G..+Is..-pWt.hhDthshhtQl.......................................	0	95	233	320
+7195	PF07367	FB_lectin		Fungal fruit body lectin	Moxon SJ	anon	Pfam-B_20370 (release 10.0)	Family	This family consists of several fungal fruit body lectin proteins. Fruit body lectins are thought to have insecticidal activity [1,2] and may also function in capturing nematodes [3]. 	25.00	25.00	36.50	42.20	19.40	23.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.86	0.71	-4.57	14	44	2009-01-15 18:05:59	2003-09-17 12:52:52	6	4	31	32	22	53	0	129.80	40	82.04	CHANGED	MSYTI.....plRlhpss..sshhplVE+TsWhYANGGTWo-sc..Gth.lLoMGGSGTSGhLRFp.ssuG-hFhVslGVHNYKhWCDllssLps.-sTulplpPcYY........susRhpsp.tQhushpspstcG+slplpaphs-GNsLpAsls	.................MsYsIplclhpsp..sshhplVEpssWpaupGGTWo-ts..Gth.sLoMGGSGTSGhLRFp.sssGEtFhVslGVHNYKpWCDIlssLss.stTultlhPcYY........s..sstRhp.hp.pQhsphphp..s...pGcslthpYpht-GssL.ssl.h.............................	0	7	13	20
+7196	PF07368	DUF1487		Protein of unknown function (DUF1487)	Moxon SJ	anon	Pfam-B_20425 (release 10.0)	Family	This family consists of several uncharacterised proteins from Drosophila melanogaster. The function of this family is unknown.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.26	0.70	-5.11	7	111	2012-10-02 17:28:28	2003-09-17 12:55:20	6	3	19	0	51	291	82	213.40	36	71.11	CHANGED	sWpuPphMllhc-GDlssAhahLlculppPFAsssVAolhVpEoIt-EhlcRl+sph+PLspclupHPsYlpslpclcp..hpschIhu...........psh.ssASPllVh.DhsHpahGs.tPTGllThHTFRshpEssplht+E.sLsFsuVslWsE+lussY-Llstls.sshahlNChsssLp.Ihp.atsppspVllt+saHYEoLhlsGchKhIVaPlushh	...........W.uPpLMllF-sGDlso.Ah.c.h..Ll..p.S..L...p...s..P.F...u..ss..uVA..o..VLlpESIt-pFlpplts...ch........+......P.......L........s......p........p...........V...u....p....H.....P...s.....Y...l....+....o..L......p.....p..lcp.......Lps.csltu....................c.s.h..sp..u...S.....PllVh..D.h...s...H......p...a..L.G....s....GP...T..G.....VlTl.HTFRTspEAsplt.p+E..sLsas.u.VS.lWsE+lussY-LlstLs.sshahlNChsssLsPIhp.atsppspVhltcsYHYEoLhlssch+lIVFPlus.......................................................................................................................................	0	9	10	32
+7197	PF07369	DUF1488		Protein of unknown function (DUF1488)	Moxon SJ	anon	Pfam-B_20604 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.	21.20	21.20	21.50	21.20	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.62	0.72	-4.14	70	961	2009-01-15 18:05:59	2003-09-17 13:14:29	6	1	762	1	202	509	12	78.20	37	90.60	CHANGED	sIpFssp...saDssppslpFsuhssGtplpCtlospsLpch.st...tssp.....ppphlssFcptRtcIEchAcphlpp....sststlhLp	.................tItFPsp..tpastsppslhFsAhlsGhplsCAIos-uLt.+F.......suss.....scp..hLuuFcpaRaDlEEtAEsLIpc.p..scpGhlhL.........................	0	18	60	126
+7198	PF07370	DUF1489		Protein of unknown function (DUF1489)	Moxon SJ	anon	Pfam-B_20654 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be founds exclusively in the Class Alphaproteobacteria. The function of this family is unknown.	25.00	25.00	32.20	31.80	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.79	0.71	-4.65	54	250	2009-01-15 18:05:59	2003-09-17 13:18:14	6	1	248	0	84	197	185	137.40	50	96.12	CHANGED	LlKLsVGs-Sl--LpsW.sp+....ttts.ss.shHlTRMhPKRtsElLs.GGSlYWVIKGhltsRQpllsl-phsssDGIpRCslVL-PcllcspspP+RPFQGWRYLpspDAPsDLs.tucsst.ssLPscLpppLs-LGll	..........LlKLsVGs-Sl-DLtsWhspR........pst...uh..s..spth.HsTRMhPKRt-ElLs.GGSLYWVIKGplpsRQ+llcIcshscu-GIsRCpLVL-Pcll.spspP+RsFQGWRYLpsp-APtDLs....sucuut...ssLPscL+pELscLGLL...	0	23	54	64
+7199	PF07371	DUF1490		Protein of unknown function (DUF1490)	Moxon SJ	anon	Pfam-B_20678 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. Members of the family seem to be found exclusively in Mycobacterium species. The function of this family is unknown.	21.00	21.00	21.30	21.70	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.85	0.72	-4.03	8	169	2009-01-15 18:05:59	2003-09-17 13:37:13	7	1	75	\N	23	55	1	90.00	60	95.79	CHANGED	MVhaGLLAKAusoVVTGlVGVuAYEsLRKAluKAPLRpsAVoustLGLRGoRKAE....EAAESARLKlADVMAEARERIGEEsPsPAluDs.c-	........................MshashLAKAssTVlTGLVGVsAYEsLRKAluKAPLRpuuVossAhGLRGTR+AE....EAAESARLpVADVlAEAR..ERIGEEuPsPAlucsc...........	0	8	13	19
+7200	PF07372	DUF1491		Protein of unknown function (DUF1491)	Moxon SJ	anon	Pfam-B_20742 (release 10.0)	Family	This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in the Class Alphaproteobacteria. The function of this family is unknown.	25.00	25.00	42.00	42.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.27	0.72	-4.11	53	260	2009-01-15 18:05:59	2003-09-17 13:39:21	7	2	258	1	89	215	166	106.20	37	92.50	CHANGED	LsuchWVsAhlRRlpstGhsAhVhp+GDcsAGAVlVK.lssh-GpApLappuhph........sGsRtWhhh....ssssEs-lDstlsRppcFDPDLWllElED.+pGc+hL-ps	......LpochWVuAhlRRlpssGs..Ahlt++Gss-AGAlhlK.lss..h.sGpssLau.usps............sG-Rhahph......pssc-tsscstlpRch+FDPDLWlVElED.cpupchh..t.......	0	25	58	68
+7201	PF07373	CAMP_factor		CAMP factor (Cfa)	Moxon SJ	anon	Pfam-B_20762 (release 10.0)	Family	This family consists of several bacterial CAMP factor (Cfa) proteins which seem to be specific to Streptococcus species. The CAMP reaction is a synergistic lysis of erythrocytes by the interaction of an extracellular protein (CAMP factor) produced by some streptococcal species with the Staphylococcus aureus sphingomyelinase C (beta-toxin) [1]. 	23.30	23.30	24.20	24.10	23.00	21.30	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.55	0.70	-4.85	9	517	2009-09-11 06:24:37	2003-09-17 13:44:42	6	3	137	\N	15	141	1	226.20	41	81.27	CHANGED	spsos.ts...pp..tstptcphhptLNtchspLpsh.pcslpGo-.....htcplschlcssccLKsulcs.sc...shYDhsSIssRVEhlsssl-sIphuTpsLpsKVppAHl-hGhuITKhlIhllsPhuoscplcsplsslKth.tKV.sYPDLpPTDtATlYsKsKLsKtIWpsRhsRDppVLshKshcVYptLNKAIT+AsGVphNPpsTVtpVDptlpsLpsAhQTALc	............................................................................ss...........tpshsss-AcptlptlNuRIspLpcs.QKss.uSp............ht-pIpcLLc.s.....AhcL+ssl-sls+...G..sl...shhDh.soIssRVcLlssssDTIpsAspTLQsKVpsAHs-lGLpIs+AlllhlsPsSTssQLp-EhAAlKstls+lpsYPDLpPsDsATlYsKspLs+tIhQlR.....hsRsppl...lshKstsshctLN+AIo+AsuVphNstsTVupVDpAlppLcAAYQsALp................................	0	13	14	15
+7202	PF07374	DUF1492		Protein of unknown function (DUF1492)	Moxon SJ	anon	Pfam-B_20776 (release 10.0)	Family	This family consists of several hypothetical, highly conserved Streptococcal and related phage proteins of around 100 residues in length.  The function of this family is unknown. It appears to be distantly related to Pfam:PF08281.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.28	0.72	-3.90	6	341	2012-10-04 14:01:12	2003-09-17 13:47:25	6	2	248	0	28	243	4	92.40	22	68.36	CHANGED	LLSSPKWpsDKVQGGp++KhDDVYl-Llsh....KEsIEpcTsEAIp++lELp+hIspLcNscSRolLpMVYIsKhssaplhDcLshS+oTYY+hh+.Ah+ELs	...........................................h.t.............................t....h.hh.h.....p......h.p..ph..tphhp....pp.h...c..lp...p.hIs.c.Lt......s..spp...R..p..lLp.hhYl..s..c..hs..h....p..lsccls.hS.csohYcl+pcAlpcL......................	0	11	19	22
+7204	PF07376	Prosystemin		Prosystemin	Moxon SJ	anon	Pfam-B_20835 (release 10.0)	Family	This family consists of several plant specific prosystemin proteins. Prosystemin is the precursor protein of the 18 amino acid wound signal systemin which activates systemic defence in plant leaves against insect herbivores [1].	25.00	25.00	49.00	283.70	24.40	18.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.91	0.71	-11.58	0.71	-4.92	3	8	2009-01-15 18:05:59	2003-09-17 13:55:29	6	1	7	0	0	9	0	197.50	82	99.87	CHANGED	METPSYDIKNKGDDVQE..KTKL+HEKGGDE+tKIIEpETPSQDIpNKs........DDAQphPKVEHEEGGstKEK.lEKETlSpCIIKhEGDDAQEKlpVEYEEEEh.KEKIVEKETPSQDIuNKGDDAQEKPK.......................................................................VEHEEDGDEKETPSQDI.KIEGEDAQEIPKVECEERE...KIVIRVDLAVHSTPPSKRDPPKMQTDNNKL	.......MtTPSYDI.KNKGDDhQEE.KVKLHHEKGGDEKEKIIEKETPSQDINNKDTISSYVLRDDsQEIPKhEHEEGG.sKEKIVEKETISQhIIKIEGD.DAQEKLKVEYEEEEYEKEKIVEKETPSQDINNKGDDAQEKPKVEHEE.GD-KETPSQDIIKhEGEGALEITKVVCE......KIIVRtDLAVpSpPPSKRDPPKMQTDNNKL	0	0	0	0
+7205	PF07377	DUF1493		Protein of unknown function (DUF1493)	Moxon SJ	anon	Pfam-B_20460 (release 10.0)	Domain	This family consists of several bacterial proteins of around 115 residues in length. Members of this family seem to be found exclusively in Salmonella and Yersinia species and several have been described as being putative cytoplasmic proteins. The function of this family is unknown.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.53	0.72	-3.97	18	511	2012-10-02 01:16:24	2003-09-17 13:59:56	7	2	255	0	69	887	434	104.30	38	92.53	CHANGED	M..sslppclh-hl+cchGshh.....tchpLT.so-LcpDLplstsDsc-LhpcFhccFsV-husFphppYF.P..pssh..hhs.hc+p......csc.l..PlTluMLhcSA+AG+WLYD	.......................................-slppplhcLlRpph.s..h..Y.lh....KphpLo..-oDLpp.D.Lplst--sp-LMscFFccF.....NV-tusFphpsYF.P.........p...Ph........h..p....F++p.............-...s...shTIuMLl-SA+AG+WLY...............................................................	0	5	17	48
+7206	PF07378	FlbT		Flagellar protein FlbT	Moxon SJ	anon	Pfam-B_20574 (release 10.0)	Family	This family consists of several FlbT proteins. FlbT is a post-transcriptional regulator of flagellin. FlbT is associated with the 5' untranslated region (UTR) of fljK (25 kDa flagellin) mRNA and that this association requires a predicted loop structure in the transcript. Mutations within this loop abolish FlbT association and result in increased mRNA stability. It is therefore thought that FlbT promotes the degradation of flagellin mRNA by associating with the 5' UTR [1].	19.50	19.50	20.80	25.10	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.38	0.71	-4.28	49	266	2009-01-15 18:05:59	2003-09-17 14:07:26	6	2	220	0	105	208	18	123.60	35	80.56	CHANGED	L+lpL+PtERlllNGAVlcNuDR+spl.l.ss.sslLRp+Dllps--AsTPl+clYaslQhhhhs.sss.pphps.hhptlppLh.hhssscststltpssctlhsuchYcALKtlRsLlshEpcllu	.......L+lsL+ssERlhINGAVlc.u.D.R.+ssLplhNc.AshLhEpclLpPE-AsTPlRplYFssQhMLlt.ssttcp.stshahphlptlhthhpss-hhstLctlsphVtsGchacALKslRsLhshEtclh.s.................	0	27	57	72
+7207	PF07379	DUF1494		Protein of unknown function (DUF1494)	Moxon SJ	anon	Pfam-B_20601 (release 10.0)	Family	This family consists of several bacterial proteins of around 175 residues in length. Members of this family seem to be found exclusively in Chlamydia species. The function of this family is unknown.	23.00	23.00	24.30	24.30	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.11	0.71	-4.34	6	41	2009-01-15 18:05:59	2003-09-17 14:09:44	6	1	37	0	8	18	0	165.00	56	93.80	CHANGED	pKRuFLLhElLVShTLlALLhGsLGFWpR+hasSpKccE+lY+TFLpEshAYKpLRTlF.hoTSpIE-hPGhLhShlFDRGVYRDP-LAGtVtGSLaYcppptRL-L.IpS.Rpcu+.ETh.LhcpV.pV-hVshR.....ppt.uchP-RVhhsl+R+sst.s.RsLoY.FAlG+	..pKRuFL.L.ELLIuhsLIuLLLGoLGaWpR+IahSpKcKE+VY+hFLpES+sY+hLRss................F....hSThuh....Esp.t.hlFS..FDRGVYsDP+LAGsVpGoLHYDshsQclpLhlsS.R-cu+.Eph.LhoHVhph-hpshR......pu.sEhP-RlhLTlsR+ssAhPPRTLoY.FAVG+..............................	0	2	3	7
+7208	PF07380	Pneumo_M2		Pneumovirus M2 protein	Moxon SJ	anon	Pfam-B_20478 (release 10.0)	Family	This family consists of several Pneumovirus M2 proteins. The M2-1 protein of respiratory syncytial virus (RSV) is a transcription processivity factor that is essential for virus replication [1].	25.00	25.00	73.20	72.80	22.90	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.11	0.72	-3.99	3	21	2009-01-15 18:05:59	2003-09-17 14:14:51	6	1	7	0	0	21	0	84.50	67	96.47	CHANGED	MTpPKIMILPDKYPCSISSILIoSEscVssaNHKNlLpFNQNphsNHMYS.NphFDEIHWTSQELIDslQpFLQHLGIsEDIYTIYILV	MshPKIMILPDKYPCSIoSILIoScscVshaNpKNsL.FNQNp.sNHhYs.Np.FsEIHWTSQ-LIDssQpFLQHLGIs-DIYTIYILV........	0	0	0	0
+7209	PF07381	DUF1495		Winged helix DNA-binding domain (DUF1495)	Moxon SJ, Bateman A	anon	Pfam-B_20509 (release 10.0)	Domain	This family consists of several hypothetical archaeal proteins of around 110 residues in length. The structure of this domain possesses a winged helix DNA-binding domain suggesting these proteins are bacterial transcription factors.	21.60	21.60	21.60	22.90	21.40	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.84	0.72	-4.31	11	58	2012-10-04 14:01:12	2003-09-17 14:17:45	6	2	37	0	41	59	0	86.40	40	74.89	CHANGED	Ih+SLp+SclR+KILhaLhchhPpshYls-loRcV+ossoNVpGuLcGhGpRYsu-pSLlpLGLV.....pptcsGhK..hYplTc....hG+pls-hL	...............llRSLp+SclR++lLhaLhch...aPpssYluEIuRtltuDsoNVhGuLtGhG.sRYsucpSLltLGLV....pphpps.GhK...hY+lT-....hG+pls-h................	0	11	13	30
+7210	PF07382	HC2		Histone H1-like nucleoprotein HC2	Vella Briffa B	anon	Pfam-B_20179 (release 10.0)	Family	This family contains the bacterial histone H1-like nucleoprotein HC2 (approximately 200 residues long), which seems to be found mostly in Chlamydia. HC2 functions in DNA condensation, although it has been suggested that it also has other roles [1].	40.00	40.00	40.10	40.00	39.90	39.90	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.98	0.71	-12.70	0.71	-4.44	8	284	2009-01-15 18:05:59	2003-09-17 14:20:42	6	26	180	0	92	272	95	148.50	44	66.11	CHANGED	MlssQK..K+SuKKTAuK..AVRKP.......AKKAAAKKss....sRKsAAKKssARKTssKKsVAtKpsutKtss......+KssAp+hsAtK....................hss+KsVAKKssAKKssAKKssA+KTVAKK.ssA+KsAAKKAs.AKKAsARKsA.A+KAlAK+Asu.............C+KpH+HoAACKRVsoSuAst.tsGuKo+lps.....AHuWRpQLhKhsoR	............................................................tc...s.s...s+.ss..s+K.ss.......AK.K..s.s..s.KKss.......s+K.s.A.sKK..ss...A+Ks.s.s.tKts...A.t..+.p....s..s.sKK.s.....s......AKK...........s.s....s..+K.ss.A.KK.s.s.A.+.K...........ssAKKs.s.A.K.K.s.s.AKK.su..AK.........Ks.s.A+K.s..sAKK.......s.s.A.+Kss.AK....Kss..A.+K.s.s.A.+....K..ss.s.cK..s.s...Ahcss..............................hc.s..s..................................................................................................................	0	19	45	71
+7211	PF07383	DUF1496		Protein of unknown function (DUF1496)	Moxon SJ	anon	Pfam-B_20554 (release 10.0)	Family	This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.	20.20	20.20	20.30	22.10	20.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.95	0.72	-4.71	21	610	2009-01-15 18:05:59	2003-09-17 14:33:02	7	1	598	0	48	194	3	57.70	63	62.58	CHANGED	pshssuspsspp.......RsCaYpDpsYSpGAVIcl-GllLpCst-schpoNusLhWhplpp	...................EVaSouGQSuQPC.....hQCCVYQDQNYSEGAVIKsE.GlLLQ.CQR......D-KTlSTNPLlWRRVK.P.............	0	3	12	29
+7212	PF07384	DUF1497		Protein of unknown function (DUF1497)	Moxon SJ	anon	Pfam-B_20585 (release 10.0)	Family	This family consists of several phage and bacterial proteins of around 59 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this organism. The function of this family is unknown.	20.00	20.00	22.50	107.80	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.70	0.72	-3.80	2	15	2009-01-15 18:05:59	2003-09-17 14:35:51	6	2	14	0	1	8	0	59.10	92	83.98	CHANGED	MGYYDT+NEARRISKLASQNISSEQsKKEFELDpQSKFNQEMQAEFHE+IKKLGtKNGS	MGYYDTKNEARRISKLASQNISSEQNKKEFELDSQSKFNQEMQAEFHERIKKLGEKNGS...	1	1	1	1
+7213	PF07385	DUF1498		Protein of unknown function (DUF1498)	Moxon SJ	anon	Pfam-B_20610 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 225 residues in length. The function of this family is unknown.	24.40	24.40	24.40	25.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.38	0.70	-5.21	5	356	2012-10-10 13:59:34	2003-09-17 14:43:15	7	1	341	4	50	222	100	221.20	51	98.34	CHANGED	MKRSpIN-IIcEu+AFhpoFsahLPPFAYaSP--WKQR-ssuhpEVhDuRLGWDITDFGpscFAchGLTLFTlRNGuucsh..uhsKsYAEKIMhlRcsQlTPMHaHs+KtEDIINRGGGsLVlELapuDc.sstlD-co-ITVuVDGpppThsAGupLKLcPGQSICLsPGLYHuFWAEuGs..VLlGEVSoVNDDLTDNhFLEPlGRFSsIEEDEPPlHLLCSDYcpa	........................MKRSpINpllccscthhppaphpLPPFAhaoPpcWpp.hst..s.....shpElhDhpLGWDITDFGpscFsphGLoLFTlRNGs..hpsh..sYsKsYAEKlhhl+csQloPMHFH......hp.K.....tEDIINRGG.GsLllcLasus.....ssphs............p...c......oslTVslDGpppThsAGspL+LpPGESIsLsPGlYHsFW.u..E..s..Gh.........VLlGEVSpVNDDppDNhFh.c.P.luRFssIEEDEsshhLLCs-Ysp..............	0	10	26	40
+7214	PF07386	DUF1499		Protein of unknown function (DUF1499)	Moxon SJ	anon	Pfam-B_20643 (release 10.0)	Family	This family consists of several hypothetical bacterial and plant proteins of around 125 residues in length. The function of this family is unknown.	22.60	22.60	22.80	23.50	21.80	22.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.51	0.71	-3.93	120	649	2009-01-15 18:05:59	2003-09-17 14:46:02	6	5	562	0	243	562	331	121.10	25	61.46	CHANGED	tclssssssPsshps.ths............................................pt................tlpslt...............s.sspps........hstlhpll.......pphst.......shl.....ptsps..hlcApspotlhGFsDDlplpls.....ss.ts....hlclRSsSRlGtSDLGsNtcRlcpltstLp	....................................................................................................................h..hsss.tpPsph.s.t.......................................................pt..tltshh...........hp.sssps........hptlpph.h...........pshsh......................shl......h...ppsss......hlcspspStlh..uFs.....DDl..p...l.......plp.........sstt...........hlclRStSR.......h.....G.........h.u.DhGsNtcRlcphhptL..............................	0	79	162	206
+7215	PF07387	Seadorna_VP7		Seadornavirus VP7	Moxon SJ	anon	Pfam-B_20657 (release 10.0)	Family	This family consists of several Seadornavirus specific VP7 proteins of around 305 residues in length. The function of this family is unknown. However, it appears to be distantly related to protein kinases.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.02	0.70	-5.59	5	11	2012-10-02 22:05:25	2003-09-17 14:48:06	6	1	4	0	0	107	14	302.00	56	97.28	CHANGED	hscGQsplh+.tssFcVRFRpcGKlaclPLPNuoT+c......sIlGTIKYFTElMGLslVsNuh+LshsNVuDhp+asGNuTLstlKocl.GsLFLKKlsSLPlslssshY.aNK...YcVFARlHGIl+L+....ND.NNYcYGIILE+CYcIRlhssNhIlAGLKuLMDhHpEssssLHGDCNPpNLMCDKhGhLKLVDPusLlopsVsalN.ppYcuLTs-uEVsuFVhSCLplVucLRslcp--I...FIpchYLsLcosssDsNlpsGsRLTuL.stL-VsS.....DhlStlsMhPFluLLNslcYYslsDllShlpp-lDsEs-V	......................................................................hppGphsIhR...Gs.FclRhRphs+sasMPLPNATosc......NFLDCIKFITEpVGFDYVSsGFKLs.ANVsDFQHLNGNSTLllGKTcI.GPLILKKlRSLPCC..NDsLF.+NK...aRILARM..HGILRLK....NDhNuaKYGVI..LE+C.YKP.pI..N..FSNFl.T.A...I.sD.Lps..FHSu.s.sa.hLHGDsNP-NIMSDusGYLKLVDPV..C.L....L...E.NQVN.MVN.I-YEuLTQ.-AEKKV..F..lKSLLpLVE+QLSAsh-EI........YVsLcEsNPSFN.LpsGh+LTDLLsslDlaNsspWK.h.lNH+PMhPplulLNDLTYYchsDVpshlT-sLsDEDDV............................................................................	1	0	0	0
+7216	PF07388	A-2_8-polyST		Alpha-2,8-polysialyltransferase (POLYST)	Vella Briffa B	anon	Pfam-B_20294 (release 10.0)	Family	This family contains the bacterial enzyme alpha-2,8-polysialyltransferase (EC:2.4.99.-) (approximately 500 residues long). This catalyses the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA) [1].	22.70	22.70	23.10	26.90	22.40	22.60	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.65	0.70	-6.12	3	54	2009-01-15 18:05:59	2003-09-17 14:48:52	6	1	43	0	2	27	0	403.30	53	97.46	CHANGED	M.....LKKIRKALFpPKKFFQDS.WFsTS.......LFsLpsP+sNLFIISsLGQLNQAcSLIKhQKL+NNLLVILYToKNhKMPKLIpcSsNKcLFSShYLFELPRcPNslSPKKlLYIYRuYKKILpsIQPAHLYhMSFAGHYShLISLAKKpNITTHLIEEGTGTY.....APLLESFoY+PTKhEphaIGNNLplKGYhD.KFDILHVsFPEYAKKIFNAKKYaRFFAHuGGISoSssIANLQ+KYRIS+NDYIFVSQRYPISDELYYKoIVETLNpISLpIcGKIFIKLHPKEMtNKYIMSLFLNMVcINPR.LVVINEPPFLIEPLIYLTsPKGIIGLASSSLVYTPLLSPoTQCLSIGpIIIcLIp+pupQENTshIcEHLEIlKpFDFIKILSDlpssIsss.FKTEEThEhLLKSAEaAYKsKNaaQAIFYWQLASpNslolLGaKuLWYYNAL.pVKQ.YKMcY.-I.YIDpISlsFHDKDKhhWppIKp.aa...KRIhpsc	.......LKKl+KhhhpPhtFFpDS.WhhsS..........Lp..ppNlFlISNLGQLppspShlph.phpsNhLllLhTpKNhcMPKllhpphNKpLFpShhlh.lPppPNsho.KKllahYpsYKhll...pstchYhhSastHYuhhl.lhKKpNIpspLI-EGTGTY............sPllp...Yp...........hIhNsl.l.htY.D.+F-.lassFPphhKKhFNApKasc.FttAsulp.sspIsNl.+KYpIo+sDhIassQ+Y.IpcsLahcSllpIL.pIsh..pu+IFIK.HPKE..pp.l.ul.hshhc..hpsR.lllIsEPsFLIEPlIhhsp.KtlIGLsSSSLlYsPLlS.psQshSIu.LhIpLhpp.p....cshphlp.Hh.-IlKpFs.lpILsD...sIos...................................................................................................................................	0	1	1	1
+7217	PF07389	DUF1500		Protein of unknown function (DUF1500)	Moxon SJ	anon	Pfam-B_20659 (release 10.0)	Family	This family consists of several Orthopoxvirus specific proteins of around 100 residues in length. The function of this family is unknown.	25.00	25.00	35.50	34.80	17.20	15.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.45	0.72	-3.99	2	38	2009-01-15 18:05:59	2003-09-17 14:49:50	7	1	17	0	0	32	0	86.80	73	58.82	CHANGED	MSSSVDVDIYDAVRsFLLRaYYsKRFIVYGhSNAILHNIYRLFTRCAVIPFD.IVRhMPNESpVpQWVhDTLNGIhMNE+DVuVsVGTGlLFMEMFF..h	......................MSSSVDVDIYDAVRsFLLRHYYsKRFIVYGRSNAILHNIYRLFTRCAVIPFDDIVRT.MPNES....RVKQWVhDTLNGIMMNE+DloVsVGTGlhFMEMFF...DY..	0	0	0	0
+7218	PF07390	P30		Mycoplasma P30 protein	Moxon SJ	anon	Pfam-B_20617 (release 10.0)	Family	This family consists of several P30 proteins which seem to be specific to Mycoplasma agalactiae. P30 is a 30-kDa immunodominant antigen and is known to be a transmembrane protein [1].	18.70	18.70	19.20	19.90	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.59	0.70	-4.88	2	12	2009-01-15 18:05:59	2003-09-17 14:56:20	6	2	6	0	1	14	0	189.00	57	98.69	CHANGED	MKLKQLLNLGTALTATFSIPFVAAKCSEDDKKEKVTKPKNEPTKPVDNSKTNDNSNEMVGETNLSNSINSSNSSTQNHFGAETNAKESPALNDLYSENPATPI.p.EKGIKESSEGSKNEGDKVIAGKEAIYKDIDFDISKVKITIDKKDLKDEDLISPKKGSHKQLFFNTYKDKTKVSGKLEKDQKPWGGIAIGSVTGLPKNYSIANADSPLYISKKDKKGTAKPNGFVNVEKDGGNLKIKFRFFKFNKGsNSTVSTKVYEAIIS	.....MKhK.LLsLGTsLTATFSIPFVAAKCuEsDKKEKhpKPhpEPsKPs-NocTsDNosEhs.G.psN.s.sS.N.SsNut.......................Nssss..p.EKtIKEoS-u.Kp-G-KV.stpcshYKDIDFDhSKlKIhIsKKDlKDEDLIssKpGspKQlFFsThp.tTplpGKh..tphPWtGltIGoVTGLPcsYSIuss-sPla...+s+KGphpssGFVNVEK-GspLKIKFRFFKaNKGsssTVSTpVYEAIIS.................................	0	0	1	1
+7219	PF07391	NPR		NPR nonapeptide repeat (2 copies)	Bateman A	anon	Marshall M	Repeat	This nine residue repeat which I have called NPR after NonaPeptide Repeat.  It is found in two malarial proteins and has the consensus EEhhEEhhP where h stands for a hydrophobic amino acid.	25.00	0.00	115.20	0.60	17.30	-999999.99	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.70	0.73	-6.93	0.73	-3.28	73	570	2009-09-16 13:04:07	2003-09-17 15:05:43	6	2	2	0	555	770	0	16.90	67	98.77	CHANGED	EllEEllPEEllEEVlP	........ElVEEVlPEElVEEVlP...	0	555	555	555
+7220	PF07392	P19Arf_N		Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus	Vella Briffa B	anon	Pfam-B_20449 (release 10.0)	Family	This family represents the N-terminus (approximately 50 residues) of  cyclin-dependent kinase inhibitor 2a p19Arf, which seems to be restricted to mammals. This is a tumour-suppressor protein that has been shown to inhibit the growth of human tumour cells lacking functional p53 by inducing a transient G2 arrest and subsequently apoptosis [1].	25.00	25.00	45.60	45.60	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.45	0.72	-3.80	6	33	2009-01-15 18:05:59	2003-09-17 15:41:38	7	1	25	1	7	29	0	50.20	71	51.22	CHANGED	RFlVTVRI..RRAsRPP+VRlFVVphsRuupctoAssspAsVAhVLhLhRppR	..RFLVTlRI..RRACGPPRVRVFVVHIPRhAGEWAAPGA.AAVALVLMLlRSQR	0	1	1	1
+7221	PF07393	Sec10		Exocyst complex component Sec10	Vella Briffa B	anon	Pfam-B_20545 (release 10.0)	Family	This family contains the Sec10 component (approximately 650 residues long) of the eukaryotic exocyst complex, which specifically affects the synthesis and delivery of secretory and basolateral plasma membrane proteins [1].	21.80	21.80	22.10	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	711	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.36	0.70	-12.95	0.70	-6.35	26	605	2012-10-02 15:56:29	2003-09-17 16:31:31	6	17	278	0	437	610	1	516.80	19	80.29	CHANGED	lppsh-sFspLDpplss................luptssclGcpLcphspp+pp........tlcut.Llpaapchhspup..............................t.LppL.cp.ssspthhcsAplhppLhtlupcl..........................................sssttppspppI-pas-phEpcLLcpFssuY+cp-...hppMpchApl...LppFNGGs....sslphFlsp+phFh.pppph......p.sh......h..l.s..sspt..hh.pshpslhsclpsslppEupIIpcVF....sssppVhphFlp+lappplpphlphlLccspsh...............................SpLuYLRsLpshauhstpLsccLpsa.hts.p...........................................hsshL-pp..hpclF.sal...spYh-pEp+sLcphhtshltcFs.ph....ptp..................htph.st..t.h.........................ssp.t.........spsp.sphsphtpsphp.sppp..........................................................t....phpttcshholshshshl+tstEulsRshpLsp.....sscsscsshslhslLLphlhcpYlcsuL-.ss.........................hthsstc.tppss.ssLh.aLpslphsspIlpLhsthhps.ll.Phlsssssh+pphhptppphhpphEtplsthlpcslcslhsplphlLu.cQKKsDFpPpssshs.......................h..psTpsCtplsshL.spltpthstsls..up........................................................................NLcsFLoElGhclaphLlcHh++apVss.sGGlhlppDlspYpshlcsa....plsplsppFchL+pLusLalV.pP-sLpplsptsth...........................sthshp.lppalppRsDapphthssth	................................................................................................................................................................................................h.........................................................................p.t...............t..Lh.hh.th.t......................................................h......tt...........ptu.hh...p..pL...h.u...pp...................................................................th....h..t.ltth.p.hEpthlppFpt.......t........................ptt..............p....tth.tphuth.....L.thp.tht...............t.s.hth....alp..pp...............................................................................................p.t.hhpth..h.hpp..t..ltthF..............s..........lh.h.hhpp.lht........lt.hhp..hhp....p.t.................................................................................................s.......a..lp.l.......h...t........h...t.h..ppl.............................................................................................t..hpp.......h.pha.....ah....t.Yht.E.t.hpp..t..h.pa............................................................................................................................................................................................................................................................................................................................................................................t.pt.h.s.p.hshphlp.ht...tuhtRsh.h..................................tph..tth.tlh...........hllp.h..tal.t.uh-.....................................t.tt........t..t...t.t...sh...ah.hlp.ss.lhthhp.........hpp.lh...h.h.....sp.ph..............h.......ttp......pth.p.h-.thsthlp...t.............slsshht..hph.hht.tQt..tpD..apP..ttt...........................................................................o.ss.tlsthl.p.t....hp..hhtshs....tp..........................................................................................s.hp.sh.tE.......lu.phhphlh.cHh.pp.th.ss..Guhh.hh..........pD...h...st...Yhphh.p.p.h.......................t.......l...haphLptlsplhll...ts.p.thpphh.p...t................................t.hp.p.hhtahphRtDh........t...........................................................................	0	164	262	375
+7222	PF07394	DUF1501		Protein of unknown function (DUF1501)	Vella Briffa B, Studholme DJ	anon	Pfam-B_20578 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 400 residues long.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	392	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.32	0.70	-5.63	51	1229	2012-10-03 20:55:17	2003-09-17 16:41:31	7	11	455	0	491	1424	2193	366.90	22	81.41	CHANGED	AKplIhLahsGGPSpl-hFD.KPphpphpspsh......................................thttpGpsGh.lu-hhPch..uphsDc....lsll+Shhscths...Hs.AthhhpTGtt................shPohGuWhsauLGsts..psLPsalshst.......tth.tsuspsausGFLsutapuhsh.psssss..............lhslsssss.lstppppptlshlsphspphh......ppsscsphts+ltpaEhAh+....Mpspss-shDlssEsppshchYGhss...t..tt...................FuppCLhARRLlEcGVRFlplhps.......G..........WDpHs.....slppshspts...tplDpshAALlpDLcp+GhL--TLVlasuEFGRTPh.........pss.........tGRDHpspuFohahAGGGl+uGhsaGpTD.....-huhssscss..hplpDlaAThL+hhGlDcpclsathtGc.h+Lss...pucllc-ll	.......................................................................................................................................................................................................................................+tllhlahtGGssthshhs..ps.p..h..hh.ttpsh....................................................u....h.h.s.p...h..hsth..........sphscc..............hslh.u.h.....s..phhs..........cs..u.th.hhts..G.......................h..tsh..h...h..t...h.sstp...............shPshhhht.......................t..sh..ssp..ht....s..G.a...Lsp..hh....ps...h.h..tstsss.............................................hhsl.ss.st...s...h.s...h....t...t...t.tpt..h.s.h..h..t...t....h...st...............tt.ts...s.p.h...t..s.h.ht..t...h.p..h.uhp......................hp......s...t....h.p...s.h..c.l.s.p...-.s..p...t..h..h.p.h.h.G.st.....................................................................hu.t..p..s..l...h...A......p.c......h....h...c..p..G....s..+..h..l.plt..hs..............G..............WDs..Hs.................s.hs......t.....h...sp.hh..................tplDpuluALh....pD...Lp......p...........p......G......h............h.......-.......c......T......lVlhhuEFGRTst........................tN.us....................tG...p.....D......H.spuh....s....h.......h....l....sG...G.......ul....+............G.......G.h.shG..p.s.s........p.h....u...h....t..........t..........................c...lhss.hh.h..hshs.p.t.h.h.h.t.h.up.htl.......st...........................................................................................................................	1	299	398	453
+7223	PF07395	Mig-14		Mig-14	Vella Briffa B	anon	Pfam-B_20642 (release 10.0)	Family	This family contains a number of bacterial mig-14 proteins (approximately 270 residues long). In Salmonella, mig-14 contributes to resistance to antimicrobial peptides, although the mechanism is not fully understood [1].	19.70	19.70	20.20	19.90	19.50	19.60	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.55	0.70	-5.38	5	242	2012-10-02 22:59:21	2003-09-17 16:48:01	6	3	223	0	34	157	10	250.40	50	88.21	CHANGED	HPLVV-pLu-huuIPVRYLuWEpuGElKAAIssWGRpLALSKDsLKRtGKKuLFDLGNAEIILPsAuDs+ssLRH+sRYLSALNcspIssL+...AQKEQLAhARsPEDFSKKFRYNQRRElRLlEEAGGsVRslu-FSuuElAulYl-LFpRRWG..FPATGA-chAcVlEpLR-LLhGSVLaLNspPIAIQlVYRuEAPpWVSlEYlNGGV..DPETRcFSPGSVLSaLNTQuAWEDARuhsKsLRFSFG..RADREYKDRWCsPsPVaQ..s	..........................................................................................................................................................HPDlV-ahhc+ash+F+F.F.+.acccscIKGA.......YFlsNDppl...uh.hsRRsFPLusDEILlPh...APDl..R..saLPcRTp+LSAL+pspIpNAha...+lspK+QsC...llK.......E...s..FSsKFc+sRRpEhp+FlcpGGoV+sV..u-hS.ucE...LspIa...l-LFc.....pRaGt..p.sshs.A-pLAs.FFSpL+c....LL.....FGalLal-shPCAhDlVLKuESphsVYaDssNGul..cs..EsRsLSPGSlLMWLNlscA+caCpcppKp.LhFShG..+P..-..hEYKchWssPh.sGp.s............................	0	1	6	22
+7224	PF07396	Porin_O_P		Phosphate-selective porin O and P	Vella Briffa B	anon	Pfam-B_20808 (release 10.0)	Family	This family represents a conserved region approximately 400 residues long within the bacterial phosphate-selective porins O and P. These are anion-specific porins, the binding site of which has a higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates, while porin P has a higher affinity for orthophosphate [1]. In P. aeruginosa, porin O was found to be expressed only under phosphate-starvation conditions during the stationary growth phase [2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.16	0.70	-5.59	34	1073	2012-10-03 17:14:37	2003-09-17 17:09:15	6	6	497	3	306	1050	285	310.00	14	76.92	CHANGED	hplthp.hpush.phs...tps.tptpsusF..ph+ch+LplpGchsc.......chsYphp.clspssssts..s.ht..............h-hsalsach...scp..hslphG+.ts.aGthEh.sssslthhchu.....-hhs............hh..sshhtGlsssaphssspp.lphplh............ss..pssshsctassp...............thttstsshshshsasushh.sphhphchuhshtppActpssp.hlshGsthshs.......phth.hchhhu..slptphhhsphhp...........ttthpshpapuhhsphsYphsschpha.....................spGhaEsssthcthshttt.............hthp+shsahsGlpaaPh..tpsL+halsYltpchchpptsp..s....ssstlslth.Yph	..............................................................................................h...............ht.......tt...t..t....p....p.s..s.h......ph+c.h+lthp.G..p...hh.p........h.tap..h..p..hc...h......sps..s..s..............................................................lp-Aalpa..ph.........pp.....hplphGphphs..a.....uhp.pht.osp....h.h..h..pps..................h.p..........................................t.h........s..h...t.h..ths...h..t...h..p..h..t..tt...t..h.......h....t..h.shh.............................ss....t..s...s.st.s.....t..h.s..s..p....................................................hth.t.h.....th..............t...............................................................t....ht..........h...t.......t.......t.s.t.....t....t..................h........s........t.t......................hhshph..hhht....ht..h..p.schh..hhthtt..............................h.....s..h....p..h......u.h..asphsahh..h..s....p.....h..........................................h.......h.c...hhh..ths..hphtt................................................ttp.p...th.thGhpaa........th.....ch.hsa.....h....t..p.........................t.....h...h............................................................................................................................................................................................................................................	0	111	228	276
+7225	PF07397	DUF1502		Repeat of unknown function (DUF1502)	Moxon SJ	anon	Pfam-B_20836 (release 10.0)	Repeat	This family consists of a number of repeats of around 34 residues in length. Members of this family seem to be found exclusively in three hypothetical Murid herpesvirus 4 proteins. The function of this family is unknown.	19.00	19.00	19.90	19.40	18.10	17.10	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.02	0.72	-4.32	2	25	2009-01-15 18:05:59	2003-09-18 10:17:58	6	3	3	0	1	25	0	32.90	84	31.78	CHANGED	RSEGAGCPARGAGPPAWGAts.ppsutsRssut.	..RSEGAGCPARGAG.PPAWG..AGPPRRDGGNRGDGAP.......	0	0	1	1
+7226	PF07398	MDMPI_C		MDMPI C-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_20685 (release 10.0)	Domain	This domain is found at the C-terminus of the mycothiol maleylpyruvate isomerase enzyme (MDMPI). The structure of this protein has been solved [1]. This domain appears weakly similar to Pfam:PF08608.	27.80	27.80	27.80	27.80	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-10.04	0.72	-3.41	68	478	2012-10-02 14:08:01	2003-09-18 11:25:45	6	2	187	0	169	384	19	92.60	21	37.19	CHANGED	chsscsls...chlsthssphht...........thsh.hps.tshphpsss..........................................ssVpGssssllhh..hsGRhssss......lpssG-tshhst	..........................................lssDtls.....chLthh.sspht.....................hhhthpsstslpl+so-ss.....................s...st............................sssslpGsutsLlhhhsGRhsssst......lpssGDtslht.t..............	0	61	131	160
+7227	PF07399	DUF1504		Protein of unknown function (DUF1504)	Moxon SJ	anon	Pfam-B_20945 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 440 residues in length. The function of this family is unknown.	25.00	25.00	58.90	58.80	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.95	0.70	-12.56	0.70	-5.82	4	138	2012-10-02 15:12:49	2003-09-18 11:28:01	6	2	121	0	52	121	122	416.10	45	97.30	CHANGED	Mhhss...ulplsuAlLFhsAllHTFhT.ahpRLscop.++..............utLa+lLucVElVFshWAlsLhhhhhhTEGhphuhtYhDSRNas.shFlhAIhllhtoRPIlaFuttVlphlA+.lshsushuaaaTlhhhsPLLusFlpEsuAMhlAAhhLpcphas.osS.+htYAThGlLFsNISIGGhhosFuu.slLhlhsthpW-pSFhLoHFuWKAlLAIhlssshhhhLFRKEh++hPcT.ss.......tssus-+VPshIIslpllh.VGsVlhu+tsslFhG.LFLFaLGFt+hh.hYQD.lhLpcshhVuLFhAGLVlhGs.QpWWl.slhhGMos.uhhhsuhhLohFhDNAhlsYLsp.lsshoDsa+YhlVAGuhouGGLTlluNhPN.sGhhILRspF.suoIH.ltLhLuALsPolIuhhsFhhL	...............................slplhuAlLFslAllHTFhs.aFp+Lu....+c....t.c........+..................................................................uuLaHLLuEVElVFGhWAhsLhhhhhh.....h..pG.hpt...........uhsYh-.S.R.NaTEPLFVhslMllAuSRPILphspphlptlA+.....lsh....psshuhaaslhshsPLhGSFITEPAAMTlAAllLscphaph.ssss+hpYuTLGlLFVNlSIGGsLTuaAAPPVLMVAspapWssuFMhspFGWKAslAlhlssslhhhlhR+c.h..t.p....h..s...ps..hts............t.hpcp.....lP.hhlhhlHl.lhLlG.l.Vl.h.A.HaPsl.FlG.LFLFFLGFspAhttYQs..LhL+cuLhVGFFLAGLVlhGGLQpWWLpslltuhsshslahGAhsLTAhsDNAAlTYLuS.L.lsuho....................Ds....a+YhlVAGAVoGGGLTVIANAPNPAGhuIL+spFscsulushtLhLuALsPTlluhhsFhhh...........	0	18	38	46
+7228	PF07400	IL11		Interleukin 11	Vella Briffa B	anon	Pfam-B_20854 (release 10.0)	Family	This family contains interleukin 11 (approximately 200 residues long). This is a secreted protein that stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. These functions may be particularly important in mediating the hematopoietic, osseous and mucosal protective effects of interleukin 11 [1]. Family members seem to be restricted to mammals.	25.00	25.00	27.70	27.00	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.28	0.71	-4.78	3	55	2012-10-02 01:28:15	2003-09-18 11:38:20	6	2	31	0	23	43	0	175.50	46	79.67	CHANGED	MNCVCRLVLVVLSLWPDTAVAPGPPPGSPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQsPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL	.................................................................................h-hDphs..T+pLLtsT+pLstph..+D.+.FsuD.u.-...Hs.LDSLPsLu.hS.AusLuu......LQLsusLopL+uDLhSYh+HVpWL+RAuss.SL+oh-PELGslpu+Lc+LL++LQLL.MuRL..sLPQssPssPusPLsPPuSs.WsslpuuHtILttL+LhhDWAsRuLlhLKs+........................	0	1	4	11
+7229	PF07401	Lenti_VIF_2		Bovine Lentivirus VIF protein	Moxon SJ	anon	Pfam-B_21067 (release 10.0)	Family	This family consists of several Lentivirus viral infectivity factor (VIF) proteins. VIF is known to be essential for ability of cell-free virus preparation to infect cells [1]. Members of this family are specific to  Bovine immunodeficiency virus (BIV) and Jembrana disease virus which also infects cattle.	22.00	22.00	22.60	23.20	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.38	0.71	-5.18	2	22	2009-01-15 18:05:59	2003-09-18 11:45:31	7	1	15	0	0	22	0	133.50	40	59.32	CHANGED	MERTlQSshGRRRGSSsRt+tpsslISsPuYAlaPsPpaRYPRWEFVhps.YS.TAplpKtclllTYpYAlWtR.WpIpTGFhD.uhhMTPAGTHTTtElscLDLFWlRYs.C.Hc.P.Wh-hLhGphs.+hSCRRshQAuVlopT..HoLQRLAuLpLssNtsLCWYPlGplscsoPLWhpFooGKEPTIQQLSGHP	...................................t.t.p...hhhh.hhtt.t.hctcch.ah.........................................................................................................aa....ltlCSCpKc+acI..REFhlG+HR.WDLCKSChQGEIV+pTcP+SLQRLALL+lscsHVFQlMPLWRARRs......................sh.h.h.ppsh.........	0	0	0	0
+7230	PF07402	Herpes_U26		Human herpesvirus U26 protein	Moxon SJ	anon	Pfam-B_21150 (release 10.0)	Family	This family consists of several Human herpesvirus U26 proteins of around 300 residues in length. The function of this family is unknown.	25.00	25.00	502.10	501.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.95	0.70	-5.12	2	6	2009-01-15 18:05:59	2003-09-18 11:51:38	6	1	6	0	0	7	0	293.00	61	99.15	CHANGED	Mhplh.SF.hGLshGsVIPG..sF+hh.t+o.htQlsllhhhuhuhLLTa+Rhs.h.YpPhsDhKIlhLSLhs.phss.h.hVlh.hLhFSEhRLRhIlsRChhIhPoaS.AsahGhhlulhhK.p.hscYplLlTsh.lhPhsspYtahlpSptFhhsLQ+Y+PIhKssu.hphslKsllhahlpFLhLhhllWhGKhaLsh.pspHLFFLsVlpsshFhhplaphshCullslLuGlhhphChapllFEhFlGLGaSulhhplSpsltc+shasGDLLNhFaC.sshshaF	MRRLTDSFILGLAKGAVIPGLYsFRMTEGRSsLtQIGVlITVAISFLLTFKRFDPRFYKPIGDFKIVFLSLMAsKLPShLSAVVMICLIFSEMRLRMILSRCVhIMPSYSPAVFTGhMVSLFFKSQMFDDYSVLlTsA.LLPhTlRYGWMIRSSGFLluLQKYRPILKSTSFREVDLKsLVKFTVEFLLLFTlLWIGKhFLSMPKSNHLFFLTVVNNVFFKLNVFKAAACAlVAILSGLMMNVCLYRIIFEAFlGLGFSSIMLsLSSDLKDRSFYAGDLLNGFFCLVVCCMYF	0	0	0	0
+7231	PF07403	DUF1505		Protein of unknown function (DUF1505)	Moxon SJ	anon	Pfam-B_21179 (release 10.0)	Family	This family consists of several uncharacterised Caenorhabditis elegans proteins of around 115 resides in length. Members of this family contain 6 highly conserved cysteine residues. The function of this family is unknown.	25.00	25.00	69.40	67.10	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.08	0.71	-4.14	7	20	2009-01-15 18:05:59	2003-09-18 11:54:03	6	1	4	0	20	20	0	113.80	34	82.02	CHANGED	Ms.hh.oVllhuh....slAhsssssSp..opsaspsppCh....Sscspsh.....pCphosshphppsSsCshSpYhhppsp...tssp..ss.NtVsQCopTPCsus-KlssDCtsAFu.-+lupIp	.......Mp.hh.sVLlluh....hlAhsss..ssSphpospa.sp.ucpCt..p..sssspsh.....pCphsuTWchppsssCslSpYhKKshs......ssss....-PhNGVAQCTKTPCsuoEplssDCssAFu.-+lupI.....	0	7	7	20
+7232	PF07404	TEBP_beta		Telomere-binding protein beta subunit (TEBP beta)	Moxon SJ	anon	Pfam-B_20928 (release 10.0)	Family	This family consists of several telomere-binding protein beta subunits which appear to be specific to the family Oxytrichidae. Telomeres are specialised protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. TEBP beta forms a complex with TEBP alpha and this complex is able to recognise and bind ssDNA to form a sequence-specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes [1]. 	20.70	20.70	20.90	424.90	18.50	20.60	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.33	0.70	-5.33	3	15	2012-10-03 20:18:03	2003-09-18 12:45:53	6	1	5	14	0	19	0	279.10	75	97.26	CHANGED	MSKGQpA.QQQSAFKQLYTELFNNGGDFSKVSsNLKKPLKCYVKESYPHFLVTDGYFFVsPYFTKEAVsEFHuKFPNVNIVDLHDKVIVINNWSLELRRVNSAEVFTSYANLEARLIVHSFKPNLQERLNPTRYPVNLFRDDEFKTTIQHFRHQALQQSIAKNlKQENLPDISKVoGADAAGKKuKVDAGIVKASASKGDEFSDFSFKEGNTATLKIQDIFVQEKGKDALsKluDcsDVt......KVKGGAKGKuKAAoKSA.+GKKsSAKKuDouuSADVRKSVDKIVKYTPNKPSSRKETPQKSQSAPAAGKSSAKKTTTGSKKslPANPSPSGKKSTKTTDQMTMAQFKKYLDWHEKKKGGKTSSGGKVLGKRSAGKASATSG	MSKuQ.s.QQQSAFKQLaTEhFN.GGDFuKVSpsLKKPLKsYVKESYPHFLVTDGYFFVpPaFTKEAVsEFHpKFPNVNIVDLHDKVIVINsWSLELRRVNSAEVFTSYANLEARLlVHSFKPNLQERLNPTRYPVNLaRDDEFKTTIQHFRHQALQQSlAKNlKQENlPDIuKVoGuD...KKuKVDAGIVRASsSKGDEFuDFSFKEGsTAsl+IQDIFVQEKGKDALp+ltsttps.......KV+GGA+GKtKAAoKSA..sKKssAtKt.s.tuADVRKSVDKIVKYTPNKPSSRKETPQKSQSsPA.GKSSAK+ThTGuKpplPANPSPSGKKSTKTTDQMTMAQFK+YL-WHEKKpsGKTSSGGKVLGKRSAGKASATSG.	0	0	0	0
+7233	PF07405	DUF1506		Protein of unknown function (DUF1506)	Moxon SJ	anon	Pfam-B_20962 (release 10.0)	Family	This family consists of several bacterial proteins of around 130 residues in length. Members of this family seem to be specific to Borrelia burgdorferi (Lyme disease spirochete). The function of this family is unknown.	25.00	25.00	27.50	27.00	23.40	23.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.71	0.71	-4.15	2	112	2009-01-15 18:05:59	2003-09-18 12:48:34	6	1	27	0	8	63	0	123.40	63	98.52	CHANGED	MNGVRKRLSDMSFRMINVFKDPpPL+FYKGTVVKLENDSSYQRVFDKNKYTEFAGVIIDI+PQELAlLYDSDMSDIQGYSKLYTYQDLNYELKDRISIuDLlYFEIFSIDSSIGYFTLVLKEFIWTN	...................................................MsGVRKRLuDMShRMINVFK.D.PpPL+FYKGsVVKLENDuSYQRlFDKNKYTEFtGVIIDI+PQELAhLYDSDhSDIQGYSKLYTYQDLNYELKDRISIuDL..VYFEI...F...SIDSS....IGYFTLVLKEFIWT.........................	0	4	5	5
+7234	PF07406	NICE-3		NICE-3 protein	Moxon SJ	anon	Pfam-B_21003 (release 10.0)	Family	This family consists of several eukaryotic NICE-3 and related proteins. The gene coding for NICE-3 is part of the epidermal differentiation complex (EDC) which comprises a large number of genes that are of crucial importance for the maturation of the human epidermis [1]. The function of NICE-3 is unknown.	20.20	20.20	20.60	22.30	19.10	20.10	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.05	0.71	-4.79	6	138	2009-01-15 18:05:59	2003-09-18 12:56:57	6	5	89	0	77	153	0	165.80	46	65.51	CHANGED	huSphp.LSGVslVLlhuaGsLlhllLFIFsKRQIMRFsl+SRRGPHVPlGHsAPKsL+cEIEtpLs+lQ+IpaEP+LLu......sDcs+alp...tssps..hhsYhYRMKAlDsl+-h-h.lpchutu.ophsGcslRuaLh.Lpspps.hpGscptLIDplhDhYE+ARHssstFGcsEYh+YpphLpcLsss	.............................................p.LSGVsllllhuhGsLsh.....llLFIFsKRQIMRFsh+.S.RRGPH.VPlGps.AsKs.L+cE.I-hRLsclQc.Ip.aEPpLLs......s.-.c.s+hh.....ps..ppp....t.sYhY..RM.KAlDsl+.s.E.hshpptspp.pphhGcshRuaLhpL+s....p.u.sPhcGs..ppsLIcplhDsYEpARaGss..sFGpsEYhcYpctLpcLss.s.....................................	1	23	28	50
+7235	PF07407	Seadorna_VP6		Seadornavirus VP6 protein	Moxon SJ	anon	Pfam-B_21021 (release 10.0)	Family	This family consists of several VP6 proteins from the Banna virus as well as a related protein VP5 from the Kadipiro virus. Members of this family are typically of around 420 residues in length. The function of this family is unknown.	19.60	19.60	19.60	19.70	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.36	0.70	-5.72	2	17	2009-01-15 18:05:59	2003-09-18 13:01:11	6	1	9	0	2	13	0	319.60	46	81.38	CHANGED	MMIALIQMKNMKCTLKVEETAENHELEGVSFDELsALREENAKLKpENEhLKTKlHRLESDWTTSDIVEKlELMDsQF-RIGKIMDKMREPMLFKRD-IELHGDLLARVEGLLRIKNERSEVEF-KDIQCIVGRYFSDEsKQRNLEKMIKoFEYDDIADTIALRLTaFIQDPGLRSIVYAMCKAAVLNQNYLNIEVQEIVDVTRQKYTHNARDDIDFYPMFTFDANVPEGVFDHIYKKHYLsPQSAALVHTLSHLDVNVDGsGIAhYHIGSATRFAECSVVYVDGRAYKPIRVMAEYAIFPTLPHEYKGRVEGLLLLHGGLAPITLVRVYHDVNVGGLVTGSIAASVSTLlRNCMLYSFDlYFTPNGlCINAVGNNNhVNIIDIsCCGRAFGKAPLDQGsWNRNKFMGHKHG+GSKCKQY	.....................................................................phsALRpENu+LKpENEtL+sKlcRL..Eu-hppScllEKhpL.h.-s..pa-+lsKIMDK..h......Rc..shL......Fc+D-lcLcusLLARl-sLhRlK.cpsp........psllttYFs.DtscpcsL.chl+o.pas.hhcsht.Rlhh.IpsssLhshshthCthhhh.s.Nh.NlpspplhclstpKYpHsh.ss...Y.hhs..hplspthhDHIYtKH.ls.pshslhHhhSHLsVNVsGsslAhYHlGsusRhsEsSVl.l....-s..RhaKPl+s.u.YAIF.pLPpEhchRVpGLL.hHhGlsPITLVRsht-lp....shhloGslusSlosLh+shhL.ph-lhFs.pGlhlpssGspshsph...sCCtpAFu.....................................................	3	0	1	2
+7236	PF07408	DUF1507		Protein of unknown function (DUF1507)	Moxon SJ	anon	Pfam-B_21047 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.	25.00	25.00	63.00	62.80	18.70	17.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.97	0.72	-4.24	14	527	2009-01-15 18:05:59	2003-09-18 13:03:12	6	1	527	4	46	155	0	89.70	58	95.66	CHANGED	sc.ths.pccAhtLLpuDA-KIh+LI+VQhDsLThPQCPLYEEVLDTQMFGLSRElDFAVRLGLI-cc-GKplLscLE+ELStLH-A.hpc	......p...hsh+ptAlp.LpcDA-+IL+LIKVQhDNLTlPpCPLYEEVLDTQMFGLo+EVDFAV+LGLl-cE-GKplhhcLE+ELSpLHEAFTp.......	0	12	29	38
+7237	PF07409	GP46		Phage protein GP46	Vella Briffa B	anon	Pfam-B_20855 (release 10.0)	Family	This family contains GP46 phage proteins (approximately 120 residues long).	22.50	22.50	22.70	23.70	22.00	22.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.53	0.71	-4.77	25	364	2009-01-15 18:05:59	2003-09-18 13:04:22	7	1	322	0	50	265	9	111.60	37	81.26	CHANGED	ssLpsAVlISLFTDRRA.............tssD...s.sss-pRGWWGDoasss.....plGSRLWLLpRpKLTsc..shpcAcsYAcEALpWhl-DG....hApulsVpup...psphspLsLpVplshs......DGshhshsasstW	..................................sLppAVlISLFT.RcA..............tssD..............ss....s..hG.WWGDoa.s...........plGSRL.WLLp.RpK.hTsp...lhppActYAcEAL...pWll-DG....hsspIsVpsp.....pst....spLsLslslhps......cGs.h.h.h.pat...............................	0	11	23	39
+7238	PF07410	Phage_Gp111		Streptococcus thermophilus bacteriophage Gp111 protein	Moxon SJ	anon	Pfam-B_20904 (release 10.0)	Family	This family consists of several Streptococcus thermophilus bacteriophage Gp111 proteins of around 110 residues in length. The function of this family is unknown.	25.00	25.00	26.40	25.50	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.43	0.72	-3.89	2	14	2009-01-15 18:05:59	2003-09-18 13:07:44	6	1	14	0	1	15	0	98.30	43	76.44	CHANGED	MKpAWpIAKEAstKhGhKAhEahuEuLKMAWo.AK......tchpslcE+hhchG..cYo......hh.sLD.....pFNEl..hthphs.Yt.chhADhDs.thYhhhpKshcst	..MppAWcIAK-AscKFGGKAhEYluEuLKMAWutAKst...ssolschpslcp+h.pKsG..cYo......hh.s.LsauK-hp..............................................................................................................	0	0	0	1
+7239	PF07411	DUF1508		Domain of unknown function (DUF1508)	Moxon SJ	anon	Pfam-B_20853 (release 10.0)	Domain	This family represents a series of bacterial domains of unknown function of around 50 residues in length. Members of this family are often found as tandem repeats and in some cases represent the whole protein. All member proteins are described as being hypothetical.	20.00	20.00	20.00	20.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.23	0.72	-4.53	103	1558	2009-09-14 11:58:01	2003-09-18 13:16:35	7	9	909	14	301	816	131	48.60	40	69.96	CHANGED	spsGcahFpLKAsNGplIu.oSEsYso+suscsGIpSV+pNusssshh-h	...........ussupahFs.LK.A.uNsplIs..oSEh.Yso+sSscpGIsSV+sNusppphh-..............	0	71	186	255
+7240	PF07412	Geminin		Geminin	Vella Briffa B	anon	Pfam-B_20861 (release 10.0)	Family	This family contains the eukaryotic protein geminin (approximately 200 residues long). Geminin inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex, and is degraded during the mitotic phase of the cell cycle. It has been proposed that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle [1].	21.10	21.10	21.20	21.50	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.43	0.71	-4.63	7	153	2009-01-15 18:05:59	2003-09-18 13:18:27	7	2	84	11	87	154	1	156.00	30	67.08	CHANGED	MssSMKQpp..EpspENlKs........ussPRRTLKhIQPSAsGsLVGRpsE.sKulsKRKhWsspLsSpsspsts.Vt.Eps..ENcs..tslopEAaDLMIKEsPoupYWKEVAEcRRKALYEsLpENEKLHKEIEtKDpEIARLKpENcELtElApHVQYMA-MIERLoGcs.DNLEsLcs.ph......-sEptts-.p..--o-	..................................................................................................................................................................................................+pp..hs.s............t.....t....t.......pp....t...........p......tt...........pptp...........tth..pu....DLh.pp......pPsp......pYWK-lAEcRR+ALh-uLpENc+..LHc...clE...pKppE..Iu...pLK...cENccLtE...l.ApcspahAphl-cL...t...................................................t....................................	0	21	27	52
+7241	PF07413	Herpes_UL37_2	Herpes_UL37; 	Betaherpesvirus immediate-early glycoprotein UL37	Moxon SJ	anon	Pfam-B_21151 (release 10.0)	Family	This family consists of several Betaherpesvirus immediate-early glycoprotein UL37 sequences. The human cytomegalovirus (HCMV) UL37 immediate-early regulatory protein is a type I integral membrane N-glycoprotein which traffics through the ER and the Golgi network [1].	25.00	25.00	34.60	34.50	18.90	17.10	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.88	0.70	-5.61	6	101	2009-01-15 18:05:59	2003-09-18 13:33:48	6	1	24	0	0	73	0	276.10	58	79.43	CHANGED	sshssslcCpYchshhpc+psps..tChhsChhNtsLlasGsClus+ssl.lNhsh.spuh+c..........t+sshL+lGlpYYhcGhhlRsllucst......psNsoplsGsltC....W.csssoGGplTLNhosp......RhlhsscsthptspWcustpcos.........sVhplLscpsphDhhFLpchCP+Lscc....h.+h+sspsp.pssVpscopsspslhssWspuWusWoKYuEht.h..hhsthshhhpscsRshuch....shlGlFhlsuGohslLsLFCsLShhpRRcll+Dh	..............GhGVSVRCTYHGTDlNlTSNsTSMNCpLNCTpNpTQIYNGPCsGsEu+LPLNVTF.pQSRRp..........WHSVMLpFGFQYHLEGWFPLRlLNESR......-hNVTEVpGElAC...FpNDTNlTsGQLsLNhTG+S..YVLRAlA+TS..PFESpV+W.EE.T.NsTsssos.....pNTsTVMphLspYAESDYIFLQDMCPRFL+R.....olKLoKNppppNsTFT...Gs...N.hToLPhWT.scCcGWpYWTTLShM.....W+NRRSALLRAKSRALGHW....ALLSICTVAAGSIALLSLFCILLIGLRRDLLEDF....	0	0	0	0
+7243	PF07415	Herpes_LMP2		Gammaherpesvirus latent membrane protein (LMP2) protein	Moxon SJ	anon	Pfam-B_21212 (release 10.0)	Family	This family consists of several Gammaherpesvirus latent membrane protein (LMP2) proteins. Epstein-Barr virus is a human Gammaherpesvirus that infects and establishes latency in B lymphocytes in vivo. The latent membrane protein 2 (LMP2) gene is expressed in latently infected B cells and encodes two protein isoforms, LMP2A and LMP2B, that are identical except for an additional N-terminal 119 aa cytoplasmic domain which is present in the LMP2A isoform. LMP2A is thought to play a key role in either the establishment or the maintenance of latency and/or the reactivation of productive infection from the latent state. The significance of LMP2B and its role in pathogenesis remain unclear [1].	25.00	25.00	88.20	87.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.99	0.70	-5.90	3	276	2009-01-15 18:05:59	2003-09-18 13:47:27	6	1	6	2	0	98	0	230.90	53	99.99	CHANGED	MuSLEMpPLG.AGuPuosGGPDGsEGuuNspYPSuFGSSssoPGP..PssEDh-us-csPPPY-us...sGsctGsYQPLGsQDP.SLYAGLGpsGGsG.LPPPPYSPRc-oSpHlYEEs+.cuoMsPsWLPVIsAPYLFWLAGIAASCFSASVSAlVsoTGLALSLLLLAALsNSYAAQpRKLLTKLTlLVAVVTFFAILLTWlVpPsPpNuIVFALLsAAuGLQuIYlLVMLLhLLhAYRRRWRRLoVCsGLLFLACsLLLIVDAIaQLSPLLGAMTVVALTLLLLAFlLWLSSPaGlGALGAALLTLAAALALLASLILG-LNLATMFLLMLLWTLVIILI...CSoFPtothLLoRWLLYALALLLLASALLAGGSILQT..huusoTEFFPsLFCMLLLIVAGILFILAILTEWGSGSKTYGPVFlCLSGLLTMsAGLVWLTLMpKVLLSAWILTAGCLIFFIGFhLFGVIRFCRhCCFCCLpLESs-RPsTsYcNsV	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+7244	PF07416	Crinivirus_P26		Crinivirus P26 protein	Moxon SJ	anon	Pfam-B_21324 (release 10.0)	Family	This family consists of several Crinivirus P26 proteins which seem to be found exclusively in the Lettuce infectious yellows virus. The function of this family is unknown.	25.00	25.00	518.10	518.00	18.10	17.30	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.67	0.70	-4.84	2	5	2009-01-15 18:05:59	2003-09-18 13:50:21	6	1	2	0	0	5	0	227.00	99	100.00	CHANGED	MNNFPEIFDDESTCDYDKEIDHQELSDTFWCLMDFISSKHGKSVADINSGMNTLINIRKsLNGSGKVVSITDSYNKTYFHSQRGLTNVDSRINIDILKhDFISIIDDLQIIFRGLIYKDKGFLDSADLLDLDKKTTTRKFQEYFNILKIKIIEKIGMTKTFHFNIDFRsTISPLDKQRKCSISSSHKKTNRLNDLNNYITYLNDNIVLTFRWKGVGFGGLSLNDIKI	MNNFPEIFDDESTCDYDKEIDHQELSDTFWCLMDFISSKHGKSVADINSGMNTLINIRKSLNGSGKVVSITDSYNKTYFHSQRGLTNVDSRINIDILKIDFISIIDDLQIIFRGLIYKDKGFLDSADLLDLDKKTTTRKFQEYFNILKIKIIEKIGMTKTFHFNIDFRNTISPLDKQRKCSISSSHKKTNRLNDLNNYITYLNDNIVLTFRWKGVGFGGLSLNDIKI	0	0	0	0
+7245	PF07417	Crl		Transcriptional regulator Crl	Vella Briffa B	anon	Pfam-B_20900 (release 10.0)	Family	This family contains the bacterial transcriptional regulator Crl (approximately 130 residues long). This is a transcriptional regulator of the csgA curlin subunit gene for curli fibres that are found on the surface of certain bacteria [1].	25.00	25.00	27.80	41.40	22.80	19.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.86	0.71	-4.42	17	658	2009-01-15 18:05:59	2003-09-18 13:59:10	7	1	648	2	53	209	5	124.10	67	97.53	CHANGED	slsps.s+uR.LhpphsALGPYlREtQsc-spFFFDCLuVCVsschuPEcREFWGWWh-Lcsp-stFoYpYphGhasppGsWhstsl..pcstcclppThcsFHt+LtphLpp.hpLpLpsss-......schs	........TLPSGHPKSRLIKKFTALGPYIREGpCEDNRFFFDCLAVCVNVKPAPEhREFWGWWMELEAQ.EsRFTYsYQFGLFDKsG-WpuVslp-sEVVERLE+TLREFHEKLR-LLso.hpLcLEPADD....FpDEPVKL..	0	4	13	33
+7246	PF07418	PCEMA1		Acidic phosphoprotein precursor PCEMA1	Moxon SJ	anon	Pfam-B_20971 (release 10.0)	Family	This family consists of several acidic phosphoprotein precursor PCEMA1 sequences which appear to be found exclusively in Plasmodium chabaudi. PCEMA1 is an antigen that is associated with the membrane of the infected erythrocyte throughout the entire intraerythrocytic cycle [1]. The exact function of this family is unclear. 	21.40	12.50	31.70	12.80	18.30	12.40	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.05	0.70	-5.04	8	26	2009-01-15 18:05:59	2003-09-18 14:04:48	6	2	5	0	18	27	0	235.50	36	79.28	CHANGED	MKlISLGLISSIIFSIVLAKNSSsSsSTTGCFsFsRKKsKKlHpsssts....VKup-..-aDPDLPNLKFIDEF-PIsLEssKuRhScLD-sFlSETDGhIIDKVTGF.RRENDSslSGWYlRPYEEDYEcMIplNFIPLp...-YYQ+ppNssHKQusuPsPlsh......hPcKQEhslppp.o........................TlpE-DussLaEDct..................................ElDsEssshh......s-GEs...............cspcEh-pcsls.L........................p-tEcspp...................................hcpplpc.Ycs................hpt-tt..ttpppc.-................c.p..c.--ptsEcs-sccpspc	.......................................tpt.tSt..hspFshhpKKsK.c.hth........hc..c...aDPcLPNlKFI-EFpPlhlEssKtp..cLs-sFlSETDGhIlDKVTGF.RREN-SshpGWYIRPYEEsYEcMIphpFhPLp....p.app.psps.KQ.ssssPlsp.......PcKpcls..pp.l.........................plpEcDt.hlpE-ct.......s.........................plstt..p.h......s-t-t...................ps.sEh-tt.ht.h.........................pt-p.p.p...................................h.ptch.p.Ypt..................ht...pt...tttt...........................................ph...............................................	0	0	3	18
+7247	PF07419	PilM		PilM	Vella Briffa B	anon	Pfam-B_20906 (release 10.0)	Family	This family contains the bacterial protein PilM (approximately 150 residues long). PilM is an inner membrane protein that has been predicted to function as a component of the pilin transport apparatus and thin-pilus basal body [1].	25.00	25.00	25.40	32.50	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.45	0.71	-4.67	13	197	2009-01-15 18:05:59	2003-09-18 14:10:46	7	1	167	4	19	125	0	135.90	31	92.57	CHANGED	hVhlllsu......th.tppsspsppptpsupsshlAtphLhatsulNDatYppsspc...GslssspLGLPs..h.-stlpplIstsRlaVWhs-pP..GLsuALpcpSpsSsLlGplpsGpLlsssGsshuloLPuuIs-GslValN	..............................hhhhhlss.......h.ppp.spstpttphsssshh.AsphlhhtsslNDatYspstpc.....Gs.l..ssspL..u..LPs....sscst.lcphlppGRlaVW..h.sppP.....GLsss...L....ppp.ocs.S..uLlGhh..p.sGpLshh.u...G.ss.....s...ulslPA..uIstGulVhhN..........................	0	7	11	13
+7248	PF07420	DUF1509		Protein of unknown function (DUF1509)	Moxon SJ	anon	Pfam-B_21379 (release 10.0)	Family	This family consists of several uncharacterised viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.	20.30	20.30	20.40	22.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.63	0.70	-5.18	3	13	2009-01-15 18:05:59	2003-09-18 14:17:13	6	1	8	0	1	12	1	286.70	43	71.00	CHANGED	MFsGtATIELhERLATSWLTAIRLILoWHPlaA.sRppEP...LE+lCR-GREYIlMLSGTIpssHATWPFWQlMpKCLDWCCSFHsPDD+SCEHGSPRIGIRLEGENphFAPuLGLYSuVMTWTP..IPCasEhPlh.......PRPupSS-s-ssPSTSptps..VARVRPpVlQ++VsKTRPlDsElHRPtPlAhsN......PS.asDEPDhthp.cPQPGPSGQN.........RuPRTPT..L-sVRVtDpPVopsRu.coPSPP.csDpsDsD.slutPsRsh.RTPsspPSSP-oElsEEl.AQPDPWGTpt.hhsNRuuTPDDsSuIo-DSAcGSctshRRPsHSsoGERRloRRNRSE..uRSRSRSRSG-....RRaRRsRlRuhPGRRSsS...Rp.TVLVsSSE---	.........MFsGsuTltLIERLATSWLTAlRhIluWhPhaA..pppEP...L-pLsREuRpYIhhlSGoVpssaATWPFWpVMR+CLDWCCuFHhPcDpSCpaGAPRlGIp.cGpN.hFsP.LsLYSslMsWoP..hsCahp...........sp..psstsps.PSsup.....luRV+Phshpphs.KppP.ch-.Hpshshuh........Po..hc-s-......spsuPStps.........ptspoPT..lpsVhsh-tssshphs.tsPsPP.p.s..s.-.s.u.......hoP.....Ss.s.....h.AQP-sWsh......spptoPsDposh.-Dpschp..th.pP.+Stss-.RhsRcsppc..sRSRSRSRSt-....RRht..chR..PGcppsu...cp.sVls.Ssptp...........................................................	0	1	1	1
+7249	PF07421	Pro-NT_NN		Neurotensin/neuromedin N precursor	Vella Briffa B	anon	Pfam-B_20947 (release 10.0)	Family	This family contains the precursor of bacterial neurotensin/neuromedin N (approximately 170 residues long). This the common precursor of two biologically active related peptides, neurotensin and neuromedin N. It undergoes tissue-specific processing leading to the formation in some tissues and cancer cell lines of large peptides ending with the neurotensin or neuromedin N sequence [1].	25.00	25.00	59.90	59.80	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.15	0.71	-4.76	3	47	2009-01-15 18:05:59	2003-09-18 14:29:15	6	2	33	1	22	43	0	151.40	68	98.12	CHANGED	MtGMNLQLVCLTLLAFSSWSLCSDSEEDVRALEADLLTNMHTSKISKASPPSWKMTLLNVCSLINNLNSsAEEAGEMHDDDLVuKRKLPLVLDGFSLEAMLTIFQLQKICRSRAFQHWEIIQEDILDsGNDKNEKEEVIKRKIPYILKRQLYENKPRRPYILKRGSYYY	...................tM+lQLVChhLLAFoShSLCSDSEEEMKALEADLLTNMaTSKI..oK...AplP.WKMTLLNVCSLlNNLNo.AEET..GEhcEE.-LlsRRphPtsLDGFSLEAMLTIYQLpKICHS...RA..FQH.WELlQ..EDlLDsGNcK.sEKEEVIKRKhPYILKRQL.apNKsRRPYILKRsSYYY............	0	1	2	5
+7250	PF07422	s48_45		Sexual stage antigen s48/45 domain	Vella Briffa B, Bateman A	anon	Pfam-B_21037 (release 10.0) and Pfam-B_4621 (release 14.0)	Domain	This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation [1]. This domain contains 6 conserved cysteines suggesting 3 disulphide bridges.	20.80	20.80	20.90	21.20	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.37	0.71	-3.99	83	1042	2009-01-15 18:05:59	2003-09-18 14:56:31	8	8	16	1	195	1050	1	122.40	24	32.58	CHANGED	plcG....CDF..........................sssp.....................tpphhspshphs...........psphCplps...pss-l.lGhtCPpp......................................................hplpPssCFcpV....h.........................sppphplpsll.........ssphh.........................tppppphpahtlP.p.hpp........phphtCpCpptp	........................................................................lpG.CDF..............................................ospt...................pphhppshs.s............ttschCslph................tss-l.lGhhCPss.......................................................plpPpsCFpplY............................tsppthclppl.lt.................ts.hh......................................................hsppptphsahplP.pphpc........phpFpCpCpp..t........................	0	44	75	162
+7251	PF07423	DUF1510		Protein of unknown function (DUF1510)	Moxon SJ	anon	Pfam-B_21355 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown.	42.00	42.00	42.50	43.60	40.70	41.50	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.55	0.70	-4.97	16	275	2009-09-11 00:04:00	2003-09-18 15:34:46	6	2	186	0	28	185	0	178.30	36	98.23	CHANGED	SRapp+pK+R+tNhlLNIhIulVllLIllVuspLhh.sssppps.tp..........................c.ptptsscpcpsstEcscsEsK-susss-pcc..............pcccc-spcpcsppp.p......psppstpcsspsssssVccshssssWcPlGTpQoupHsssa.cpuStDWpEMhcAlSYATGlsp-phhlhalGNN..Gs..scAhGslpcKsssp+.YcVpIpWVDscGWKPsKVppL	......................SRhpp+pp+++pNhlLNlhIslV..lhlhllsaplhh.sp.pppts.tp.................................ppsppppstp.pcptK..pcsK-tsp.p-pcp...................tppp..pppp.c.pt.cp.p.pctcc....psptspp.s.tcpstspspcshTpssWKPlGT-....Q..sup.shsa.cpuosDWpEMppAlShAh-lP.pphhhhhlGps..Gp..scAhGslpsKpssc+.YhV.IsWV-scGWKPshVppL......	0	9	19	21
+7252	PF07424	TrbM		TrbM	Vella Briffa B	anon	Pfam-B_21098 (release 10.0)	Family	This family contains the bacterial protein TrbM (approximately 180 residues long). In Comamonas testosteroni T-2, TrbM is derived from the IncP1beta plasmid pTSA, which encodes the widespread genes for p-toluenesulfonate (TSA) degradation [1].	20.90	20.90	20.90	20.90	20.80	20.50	hmmbuild  --amino -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.21	0.71	-4.27	16	280	2009-01-15 18:05:59	2003-09-18 15:52:46	6	1	214	0	27	201	11	115.20	33	74.28	CHANGED	lLTGDTRLACEAlLCLuS..us+PuECuPSLsRYFSIct+KhpDTlptR+sFLNLCPVssp......sPEMtsLpss.lsphsGc.CsssuLNsplcphp.....................thcchthpIssplss.CphhsupsYTDap.....s+Yssssc...cts.Wscuh-hccs.tEh.ppl......pc	..................sCEulLC....L....uu....us...ts...oECpsu.pcaF.s.I.p......t..K.....K......h.s......cThcAR+sFLN.CPssst................s..........................................................................................................................................sh.............................	0	3	16	22
+7253	PF07425	Pardaxin		Pardaxin	Moxon SJ	anon	Pfam-B_21422 (release 10.0)	Family	This family consists of several Pardaxin proteins. Pardaxin, a 33-amino-acid pore-forming polypeptide toxin isolated from the Red Sea Moses sole Pardachirus marmoratus, has a helix-hinge-helix structure. This is a common structural motif found both in antibacterial peptides that can act selectively on bacterial membranes (e.g., cecropin), and in cytotoxic peptides that can lyse both mammalian and bacterial cells (e.g., melittin). Pardaxin possesses a high antibacterial activity with a significantly reduced haemolytic activity towards human red blood cells compared with melittin [1]. Pardaxin has also been found to have a shark repellent action [3].	25.00	25.00	86.60	86.50	19.20	17.00	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.39	0.72	-4.55	3	5	2009-01-15 18:05:59	2003-09-18 16:03:39	6	1	2	2	0	5	0	33.00	95	100.00	CHANGED	GFFALIPKIISSPLFKTLLSAVGSALSSSG-QE	GFFALIPKIISSPLFKTLLSAVGSALSSSG-QE	0	0	0	0
+7254	PF07426	Dynactin_p22		Dynactin subunit p22	Vella Briffa B	anon	Pfam-B_21336 (release 10.0)	Family	This family contains p22, the smallest subunit of dynactin, a complex that binds to cytoplasmic dynein and is a required activator for cytoplasmic dynein-mediated vesicular transport. Dynactin localises to the cleavage furrow and to the midbodies of dividing cells, suggesting that it may function in cytokinesis [1]. Family members are approximately 170 residues long.	21.50	21.50	22.00	21.70	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.05	0.71	-4.98	4	123	2009-12-07 10:30:11	2003-09-18 16:29:35	6	4	86	0	67	115	0	154.70	37	86.32	CHANGED	Msc...sLcpLchRLQ.LEpRlYG..tutsucPsKsA-uLs+lQsALuNhAsKRERVKILaKKIEDLlKYLDPQahD+IAlPDuMKLEFILAEEphlsu...........QAALLEQlpshpPlLDSsaIpAVPEpAoKLQRLSQIHIpQQDQsEphosEVK+LhE-YNKMhhLLSKQFsQWDEsL	.......................................................tlp.LptRlptLEphl.......h.G......t..s.ts....t....t...s..p...p...l.sD.uLs.......clpstL...ush..usKRE+l+...h...LaK+..l--L.hK.YLDPp...a.lDcl.slPcu..KLpaILApEp.lhs...........psthLEplppLpPhL-Stt.l.+slPpps.s+LppLuQlalpQp-ps.tlspcsptLhppYNphh..lScpFh.ast...................................	0	22	26	44
+7256	PF07428	Tri3		15-O-acetyltransferase Tri3	Vella Briffa B	anon	Pfam-B_21449 (release 10.0)	Family	This family represents a conserved region approximately 400 residues long within 15-O-acetyltransferase (Tri3), which seems to be restricted to ascomycete fungi. In Fusarium sporotrichioides, this is required for acetylation of the C-15 hydroxyl group of trichothecenes in the biosynthesis of T-2 toxin [1].	20.10	20.10	20.60	23.10	19.70	18.20	hmmbuild  -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.45	0.70	-5.76	3	46	2009-01-15 18:05:59	2003-09-18 16:55:56	6	2	24	2	6	46	0	385.60	77	81.01	CHANGED	ALPPLVPALYRWESTGu..RcVQRRCVGAEAIVGLEEKNRRSLYDLFIATSLRNIAPASTLLTLRNLKDMFELALVEGRFEHPECACTVSWDDQVAAIISYESPESDESARDWARGCVHVQPTAKSAIDLWTEMEEGRAAAKDNTPSKPIELFLLSDVPTDSTPIPQGATVDILFHSNHLFWDGIGCRKFIGDLFRLVGNHIGLSDStEThKMQWGQEIKNLSPPVVDSLKLDISTLGTEFDDKCTEYTSALVANYKSRGMKFRPGLALPRCuIYKLSADDSIAIIKAVKTRLGPGYTISQLTQAAIILALLDHLKPTDLSDDEFFISPTSVDGRKWLREDIASNYYAMCQTAAVVRVENLKSIAVSHKDEKEIQVRALEKACRDIKKSYDQWLGNPFLEALGLRVHNFEASYLN	........................................................................................ALPPLVPALYRWESTGs....RpVQRRCVGAEAIVGLEEKNRRSLYDLFIATSLRNV.APASToLTLRNLKDMFELALVEGRFEHPEsACTV....SWDD.QVAAIISYESPESDESARDWARGCVHVQPTAKSAIDLWTEhEEGRAA.AKDN.sPSKPIELFLLSDVPTDSTPIPQGATV-ILFHSNHLFWDGIGCRKFIGDLFRLVGNHIGLS..DSA-T.KhQWGQEIKNLSPPVVDSLKLDVSTLGTEFDDKCTEYTSAL...VANYK...SRGMKFpPGLu.LPRC.uIYKLSA-.DSIAIlKAVKTRL.GP.GYTISQLTQAAIILALLDHL.K.PTD..LSDDEFFlSPTSVDGRKWLR..E.DIASNYYAMCQTAAVVRVENLKSIAVS.HcDEKElQV+ALEKA.CRDIKKsYDQWLGNPFLEALGLRVHNFEAuYLp.....................	0	1	2	6
+7257	PF07429	Glyco_transf_56	Fuc4NAc_transf;	4-alpha-L-fucosyltransferase glycosyl transferase group 56	Vella Briffa B	anon	Pfam-B_21451 (release 10.0)	Family	This family contains the bacterial enzyme 4-alpha-L-fucosyltransferase (Fuc4NAc transferase) (EC 2.4.1.-) (approximately 360 residues long). This catalyses the synthesis of Fuc4NAc-ManNAcA-GlcNAc-PP-Und (lipid III) as part of the biosynthetic pathway of enterobacterial common antigen (ECA), a polysaccharide comprised of the trisaccharide repeat unit Fuc4NAc-ManNAcA-GlcNAc [1].	25.00	25.00	28.40	25.20	23.30	24.60	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.18	0.70	-5.50	11	636	2012-10-03 16:42:30	2003-09-18 17:16:37	6	2	599	0	55	333	10	331.10	69	97.20	CHANGED	MTsLIHVLGSDIPHHNpTVLRFFNDpLss.hsspQtR+FMlVup-suL.ssaPALclppFsuKKuLAcAVIApA+usRspRFFhHGQFNssLWLALLoGtI+PsQhhWHIWGADLYEsSpuLKF+LFY.LRRlAQtRVG+VFATRGDLsaatp+HPpVssp..LLYFPTRMcsuLsthssscscsu.phTILVGNSGDpSNcHlsAL+AIHQQF.GssV+lIlPMGYPuNNpuYIppV+psuhtLFsscNLQILoEKLsFD-YLsLLRpCDLGYFlFsRQQGIGTLCLLIQhGlPhVLsRcNPFWQDhsEQplPVLFssDsLstshlREAQRQLtulDKspIAFFsPNYlpGWppALtlAuGEss	...............................................................................MTVLIHVLGSDIPHHN+TVLRFFNDsLAA..TSEHAREFMVsGcDs.Gho-....SCPA....LS.l.pFasu..KKuL...AcAVIA....KAKANRpQRFFFHGQF.NsoLWLAL.LSGGIKPuQFaWHIWGADLY...E....l...S...p.....G......L+.a+LF..Y...P........L...RRlAQtRV....Gs.V...F.A.T.R.GDLSaFA+pH..P.+VRG.E........L.L..Y.....FPTR.M..DP......S.L..NoM.As-.R...QRtG.KhTILVGNSGDRSNcHIAAL+..AVH.Q.QF..G..D.T.V+.VVVPMGYPsN.N-AYI-E.VRQAGLpLFSpENLQlLSEKLEFDAYLsLLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNR-NP.FWQDMsEQ.HLPVL..FTTDDLNEslVREAQRQLASVDKssIA..FFSPNYLQGWppALsIAAGEss................................................................	0	5	20	38
+7258	PF07430	PP1		Phloem filament protein PP1	Vella Briffa B	anon	Pfam-B_20843 (release 10.0)	Family	This family represents a conserved region approximately 200 residues long, four copies of which are found within the plant phloem filament protein PP1. This is one of the constituents of the proteinaceous filaments found in the sieve elements of Cucurbita phloem [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.40	0.71	-4.72	3	26	2012-10-01 19:28:07	2003-09-18 17:18:52	6	3	6	0	14	73	0	125.60	24	88.55	CHANGED	CGQlsssPKWIQIPDVKEhGlQVVIKFIVEQlKIpaGDSLKF-SIYEGWYFELCPNSLKYRLHIKAIDFLGRSLpYEIIIIEEK.hL.RIaKL-SIIVILSPGHhVGPVDPPQVEKWIKIPNLQVPFVQEVSKFAlDEaN.KuGDGLKYlEIYDGWYMEMGQDNIKFRLHLKAKDCLGRlRNYEAlVLVKQFLSKRIKILESF	..............................thh......................................................................................................................sttppWhpI..t..slp..shlQ-LucaAVpEaN..K.......s.s.s..sL+FpcVhpGh.h..clspss.hc.a+.LplhAtct......up.tpYcAhVh.............................................	1	0	8	14
+7259	PF07431	DUF1512		Protein of unknown function (DUF1512)	Moxon SJ	anon	Pfam-B_21354 (release 10.0)	Family	This family consists of several archaeal proteins of around 370 residues in length. The function of this family is unknown.	25.00	25.00	62.80	62.80	24.00	23.20	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.06	0.70	-5.71	5	62	2009-01-15 18:05:59	2003-09-19 10:25:02	7	1	60	0	35	60	28	352.10	40	96.29	CHANGED	ssslaaIlohlLFalLIhLL......pclphhhlhRsIEGpLuhLEchtN-Apppllchhcsccs+-s.....EohlcRhu-FFVIsPVslDPsGIIcRh++LLcpu-D+a+chlcRhsPptDsVpRuslpsAlEllsulshIaKaVRHhLloA+KTsNhhLLlQLQMlLPhlh+lu-oYp-AsNuFlKGVPIGDSAGPLVAupLlucusp...+Ec.p+-TVsuEsElEGR+LhIVKA+GPGSoVGRhGcAVEcllc+h.u...+sccIITIDAALKLEGE+TGuVAEGlGVAMGDsGsEKapIEplAlKYGIsLcAVlIKMShEEAlosMsc-IlsAVccAlERVK-IIpEsscPGDoVlVVGVGNTVGVuQ	........h.....llthllah.lhlhlh........tp+lphh.hhtpslcstLshlcphl....s-ups....chhphLccts.....h..p-s.......cshlcR.hh-aFlI-PVsl-PssIls+h+pllcot--ph+chlp.thsPph..Dshp..hsplpsulEllsuLNhIYKVVRHYhlhA+KhsshhLlhQLQhllPhlhchu-AhpcAhssFhcGhPlGDuhGPLVAtplhhsssp....hps.s+DTVhuEs-a-GR+lhllKAcGPuuTVGRPG-AVcpll-chts....+lshIITlDAALKLEGEcTGslAEGhGVAhGssGsEKhsIEchAs+YsIPlpAlllKMShcEAITtMpKEIhpAspcshchVpclIh-pocPGssVlVlGVGNTsGVuQ...	0	13	19	26
+7260	PF07432	Hc1		Histone H1-like protein Hc1	Moxon SJ	anon	Pfam-B_21362 (release 10.0)	Family	This family consists of several bacterial histone H1-like Hc1 proteins. In Chlamydia, Hc1 is expressed in the late stages of the life cycle, concomitant with the reorganisation of chlamydial reticulate bodies into elementary bodies. This suggests that Hc1 protein plays a role in the condensation of chromatin during intracellular differentiation [1].	20.50	20.50	20.60	20.50	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.91	0.71	-3.94	4	147	2009-12-07 10:22:16	2003-09-19 10:31:06	8	1	117	0	26	101	24	74.90	46	96.62	CHANGED	ALKDTAKKM+DLL-SIQpDLtKAE+GNKAAAQRVRT-SIKLEKlAKlYRKESIKAEKpGLhp+K..PApKA.tAAKs.tpAuKsssKKAsAtssppuKAs.KuKPtoKKTusK.KsKpsShpRuhtK	.........................cchhpKlp-LhtshppD.h........t........p......h......E+GNKAAGTRARKsSL-LEKlhKpFRKtS..lcAuK..................................................................................................	0	14	23	25
+7261	PF07433	DUF1513		Protein of unknown function (DUF1513)	Moxon SJ	anon	Pfam-B_21436 (release 10.0)	Family	This family consists of several bacterial proteins of around 360 residues in length. The function of this family is unknown.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.82	0.70	-5.53	37	313	2012-10-05 17:30:42	2003-09-19 10:33:19	6	4	305	0	85	300	24	293.50	40	81.71	CHANGED	hslPsRuHulsscP............tpscuVshuRRPGpashlhDs.psGp.ht..tltusssRHFaGHGsFSsDGphLYsTENDh.ps.....ucGlIGVaDsp..p..sap+luEasotGIGPHElhhhsDG.....poLlVANGGI.cTcs-tGRtcLNL-oMcPSLsh.lsptsGpLlpphtLs.ph+phSlRHLAlsss..........GpVhhutQapGp.p-tsPLluhactGps.hphhthsppp...htshssYsGSlAsssstthlAloSP+Gsphtla.....ctsoGphltttslsDssGlushssG.................FlsoSGt.....Gp....hhphs.ttht.h...t.......sshtWDNHlhtl	...............h.slPsRuHuluh+P..................shs.pA.VsFARRPGpahhlhDh..psup........lt..hh.su.sssRHFYGHGVaStDGc....hLYATEs........-h.cs........uRGlIGVYDss..p...pap+luEassaGIG.PH-lh..h..hs..DG.......sLVVuNGGl.+Tc.t.GRt.L.....NL-oMpPSLsh....l.stsGplL-phsLstt.+pLSlRHLAhsuD......................GoVhsGpQap...Gpsc..-hs....s.LlAh+ptGts.hp....htst.-p...htthspYluSlAss.....s-..hlssTSPcGsphhlW.....stsoGpllt.ssLsDsuGVsshtsu.................FhloSGp.....Gc..............lhhtss.thp.......ph.................sslhWDNHhst.l..............................	0	17	39	64
+7262	PF07434	CblD		CblD like pilus biogenesis initiator	Moxon SJ	anon	Pfam-B_21452 (release 10.0)	Family	This family consists of several minor pilin proteins including CblD from Burkholderia cepacia which is known to CblD be the initiator of pilus biogenesis [1]. The family also contains a variety of Enterobacterial minor pilin proteins.	25.00	25.00	41.20	41.10	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	360	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.30	0.70	-5.75	5	262	2009-01-15 18:05:59	2003-09-19 10:39:02	6	1	240	3	7	118	1	303.90	54	91.10	CHANGED	IlFIh..phllsStlhuhulpAssssGslscopolu.tDRusuoPl..a.IFssaluGYssSHsL.aDRhoFLCpSSoNsssGACPTscsstspthsGpTNI+LpFTEK+SLA++sLsLcGsK+alacsssCsp.............cMsLNSssspC.spstssGssLsLYIPAGELsKLPoGGlWcATLcLclKRau-sos..aGTYTlNITVDLTDK..GNIQVWLPpF+S.sPRVDLNLRPh.Guu+YSGoNsLDMCLYDGYSTpSsSl-l+FQDD...NpousGcYsLl....KoGus-KcLsYAlSLLhGGKplsPsNGpuFoINssS.L.lNWNRl+uVoLPpISlPVLCWPusLTLso...clssP-AGcYSGpLsITFTPSSpoL	....................................h...t.p.sho............................................................................................................................s.sG.shS..slplhhTEp+SGh+hsltLpGa.+suh..ssst.....h.ss...............h..h....s.ust..Sh........................t...tphlpLal.toEh+pLPIGGlWKu+lKL+.........uss...s................htsYhAsITLNshD...spIslaFPpF.upATPRVpLsLHPh....sNuSp....hu....t.c.s.LDMCLYDGasuNAhShplhlcD-.....ss+..psG.FSlahp.tspos....spscRIDYpVpMh.....sG.t..pIs...VpNspshshss.....lN.hp+l.RPVVLPGIRhAVhCVPsPLTLssptFsVh-KpAGhYhGpLoVhFTPSh..........................	0	0	3	5
+7263	PF07435	YycH		YycH protein	Vella Briffa B, Szurmant H, Mistry J	anon	Pfam-B_21457 (release 10.0)	Family	This family contains the bacterial protein YycH which is approximately 450 residues long. YycH plays a role in signal transduction and is found immediately downstream of the essential histidine kinase YycG.  YycG forms a two component system together with its cognate response regulator YycF. PhoA fusion studies have shown that YycH is transported across the cytoplasmic protein. It is postulated that YycH functions as an antagonist to YycG [2]. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions [3].	20.60	20.60	20.80	21.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	438	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.50	0.70	-5.77	6	596	2012-10-01 23:24:42	2003-09-19 11:16:32	6	2	586	1	74	392	0	421.40	30	97.23	CHANGED	EshKSllLslLVlhSlVLTahlWsFQPDaus.....lsspcsc+s......ppshTtphspslpPhpllh.u+--psphshsssslhcchhssLpphclpslcclpccashs..h...usstI.......pl.FspslPhslF.splhpl-scs..hsphsFsRllIsh-tscsslt.lahlsc-+cpllchssospsh-plhcshcshpuchp.hsplIpsp.....ppchalPscspcLpshchlhsolsspphsphLFsDoohV...R..uSposssoYssuouVhshsscschhcY....pp.hs.-psoShpttclIpsSacFINuHGGaTs-..achash.scosploYphFlsGaPVaNppup.....spIpVTaGscslh-Y+RPhhclD.ss.hccscKpLPouEpVhsuLupps-lch-clssIslGYcMscsossst.....hVpLEPpWahKYcGcW......ahhp-uAtpulE	.................................EthKollLslLVlhSllLTah.lW.....s..hs.Pch.ss..........l.s.s.sc.s.pps.................sps.h..s...tch.ss.s...l.pPhpllh.....+p-p..sp......h.t.........h..s..s...s..s.......l....s....cl.h..ps....L...c.s.t...c...l...c...s.l.p.c....lp...p...cp.shh........hs...sshl............lsFstslPls....s..a.tpl..h.s....hs....scs......ss.p.h.p....FNR.l.l..lDhst.s.cp.....l.Yhl..sc.-.p...c...p.h..hchp.h....o.s...p....s.....cc........lhctlsp...hp...p..c..h..p.....sa...p...chhhNp..................ppclah..P..s.csp..cLp..sh..phlh..ss..lsl.....-.p....h..ps.hLF..s...D.....s..s...h..V...c..ps..c.u.ss.s..s..Y..s....s..s.s.t.....s.h.p.h.s.s.c.sc....h.hcY....ps....s.sptss......sch.tphl.toF-FlNs.HG.Ghhs........p............aR...h..a..sh....t..........t.p....s......u...p......ls....a....ph.F.l....s.....G...aP..lF..N.p.c..uh.........spIpl.....s.h....G.pcs....V.hcYpR.....sLhphs..ss..h..s..s.p..p.p..hoLPsscs...VhssLtp.sss..ls.h..c.c.lpsIsIGYchppss.....pp..p.........sscL.PpWYVcY.c..sp..W...................thp.......................................................................................................................	0	23	47	61
+7264	PF07436	Curto_V3		Curtovirus V3 protein	Moxon SJ	anon	Pfam-B_21777 (release 10.0)	Family	This family consists of several Curtovirus V3 proteins of around 90 residues in length. The function of this family is unknown.	25.00	25.00	82.50	82.40	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.04	0.72	-3.85	3	24	2009-01-15 18:05:59	2003-09-19 11:25:43	6	1	17	0	0	28	0	79.30	84	97.79	CHANGED	MVCLPDWLFLLFIFSILLQAGTNFYGTFQSGSISRKLSsLuSRFDELFlKlQQVVYTRYPSR-RTVDsRRRRGLSAIPEGuEEsoEA	MVCLPDWLFLLFIFSILLQSGTNFYGTFQSGSISRQLSSLuSphDpLFLKlQQVVYoR..sSR-RusDsRRRRGLSuIPEGsEEssE..	0	0	0	0
+7265	PF07437	YfaZ	YfaZ_precursor; 	YfaZ precursor	Vella Briffa B	anon	Pfam-B_21552 (release 10.0)	Family	This family contains the precursor of the bacterial protein YfaZ  (approximately 180 residues long). Many members of this family are hypothetical proteins.	21.40	21.40	21.50	21.40	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.99	0.71	-4.85	3	659	2012-10-03 17:14:37	2003-09-19 11:26:33	6	1	610	0	85	306	5	178.50	63	95.94	CHANGED	MsKatVAulAuLLLVAuSVNAsSFNupsG+-YTNlGlGLGTNTsGLAlSGNWs+SDDDGDVAGlGLGhNLPlGPhpATVGAKGlYhsP--GssGuAVAVGGGLuasIGsSFSLaGEuYYAP-sLSSG.lcSYpEANuGVRYNIhRPlol-VGYRYINhEGKDGsRDNslADGsYIGushsF	...............................................................................MKKhhL.A.G..h.AGMLh...V...SASs.sA.h.SISGQAGc-YTNIGV...G...F.G.TES....TG...LAL.S....G.NWsHN.....D..D.......DG.D............sA.G...V..GL.G...L..N.....l....P....l..G..P....L....hATVG..G..K.GlYTNP....p...t...G..D.E...G.YA.A...AV.GG..GL....QW...c..I..G..s..S....F...RLF..GEYY...YSPDS.LS........SG.Ic..SYEE.....AN...A.GARaT..IMRPlSIEAGYRYLNLu.G.K.D.GNR..D..N.Al.ADGPYVGVNASF.......................	0	13	32	58
+7266	PF07438	DUF1514		Protein of unknown function (DUF1514)	Moxon SJ, Eberhardt R	anon	Pfam-B_21857 (release 10.0)	Family	This family consists of several Staphylococcus aureus and related bacteriophage proteins of around 65 residues in length. The function of this family is unknown. Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	29.20	29.20	24.70	23.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.16	0.72	-4.06	3	268	2009-01-15 18:05:59	2003-09-19 11:30:45	6	1	176	0	3	46	0	64.60	67	98.32	CHANGED	MWIsISIVLAIhLLIsLSSNSc+t+EI-AL+YhNsYLFcclVKspGhpGLE-YchEl-RI+s-lKc	MWIshoIVhAIlLLlslSlNS-+t+EIpAL+YMNDYLhDclVKspGasGLE-YchElcRhss-lKc.........	0	1	1	3
+7267	PF07439	DUF1515		Protein of unknown function (DUF1515)	Moxon SJ	anon	Pfam-B_21875 (release 10.0)	Family	This family consists of several hypothetical bacterial proteins of around 130 residues in length. Members of this family seem to be found exclusively in Rhizobium species. The function of this family is unknown.	22.20	22.20	22.20	22.70	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.57	0.72	-4.25	3	22	2009-01-15 18:05:59	2003-09-19 11:41:41	6	4	15	0	12	21	0	107.50	46	88.61	CHANGED	MIDAGVHQQLGTLlAEVKNLREDlR...........RSEDRSDAuRASMaRRMDELVERVsTLEGSsstlpuDITuMKPVT-DV+KWKLMGlGALGVIGIGGAALu..VT..FADVsKRsL.hlLRGG	..........Mh.usltppltsL.t-lcplR-Dh+...........cSED+SssuRssMpRRhDELVERltsL..E.....uuhthlcsDlupMKPVT-DV+..+WKLMGhGALG..VIGlGuAALG..VT..FADlh+Rhh..lh................	0	1	6	7
+7268	PF07440	Caerin_1		Caerin 1 protein	Moxon SJ	anon	Pfam-B_22039 (release 10.0)	Family	This family consists of several caerin 1 proteins from Litoria species. The caerin 1 peptides are among the most powerful of the broad-spectrum antibiotic amphibian peptides [1].	25.00	25.00	28.50	27.50	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-6.88	0.72	-4.02	2	28	2009-01-15 18:05:59	2003-09-19 11:44:48	7	2	9	0	0	22	0	23.90	85	64.33	CHANGED	GLhpVLGSVAKHlLPHVsPVIAE+	.GLhSVLG.SVAKHVLPHVVPVIAE+	0	0	0	0
+7269	PF07441	BofA		SigmaK-factor processing regulatory protein BofA	Vella Briffa B	anon	Pfam-B_21773 (release 10.0)	Family	This family contains the sigmaK-factor processing regulatory protein BofA (Bypass-of-forespore protein A) (approximately 80 residues long). During sporulation in Bacillus subtilis, transcription is controlled in the developing sporangium by a cascade of sporulation-specific transcription factors (sigma factors). Following engulfment, processing of sigmaK is inhibited by BofA. It has been suggested that this effect is exerted by alteration of the level of the SpoIVFA protein [1].	22.30	22.30	22.40	22.30	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.40	0.72	-3.99	32	390	2009-01-15 18:05:59	2003-09-19 11:48:48	6	1	376	0	106	283	8	78.00	31	90.69	CHANGED	llu....llllhllstshhpPl...+hlh+lslphllGslhLahlNhhGuhhGl....plsINhlTshluGlLGlPGllhLlllc.hl.l	......................h.lu.llhlhllhtl..h.tsl.......+hlhchlhpsllGsllLallN..lhG.s..hhsh.......aIsINhhTuhlsGlLGlPGVshLlllphh..h........	0	42	82	93
+7270	PF07442	Ponericin		Ponericin	Vella Briffa B	anon	Pfam-B_21790 (release 10.0)	Family	This family contains a number of ponericin peptides (approximately 30 residues long) from the venom of the predatory ant Pachycondyla goeldii. These peptides exhibit antibacterial and insecticidal properties, and may adopt an amphipathic alpha-helical structure in polar environments such as cell membranes [1].	25.00	25.00	27.40	58.60	18.00	16.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.59	0.72	-4.13	3	5	2009-01-15 18:05:59	2003-09-19 13:47:52	6	1	1	0	0	5	0	29.00	71	97.32	CHANGED	GWKDWhKKAGEWLKKKGPGIhKAALKAAT	GWKDWlKKAGEWLKKKGPGIlKAALpAAT	0	0	0	0
+7272	PF07444	Ycf66_N		Ycf66 protein N-terminus	Vella Briffa B	anon	Pfam-B_21840 (release 10.0)	Family	This family represents the N-terminus (approximately 80 residues) of Ycf66, a protein that seems to be restricted to eukaryotes that contain chloroplasts and to cyanobacteria.	20.70	20.70	21.10	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.81	0.72	-4.26	16	155	2009-01-15 18:05:59	2003-09-19 16:08:48	6	2	108	0	55	167	131	82.00	43	29.81	CHANGED	lNhshGPuolLGlhLsluGllLYhlRsh+PEluRDaDlFFuolGLLsGGILlFQGWRLDPILLFuQhLlsGTslFFuhEoIRLR	...............................................................lphshs.uslLGIhLul.uuhsLY...h.l.....Rph+PcluRDtD.lFF.....uulGL..LsGhILhFQ.GWRL..DPIL.FGQhLlsusslaFuhEolRLR............................	2	14	41	53
+7273	PF07445	priB_priC		Primosomal replication protein priB and priC	Vella Briffa B	anon	Pfam-B_22037 (release 10.0)	Family	This family contains the bacterial primosomal replication proteins priB and priC (approximately 180 residues long). In Escherichia coli, these function in the assembly of the primosome [1].	20.50	20.50	20.60	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.21	0.71	-4.79	21	862	2009-01-15 18:05:59	2003-09-19 16:34:29	7	3	792	0	84	387	9	162.00	41	94.83	CHANGED	LppLcsplspLtppsuslscpt.........phpshFDcpLFpsRuphLpsYlpEscpsLstLpptsppsph..tpssaLsE+LsuQIpAlpREluTpslRcp-sts...................pshsclYpcLupHQ-aERRLhsMlp-RchpLspsssh.cpQplp+ElhAhEuRLsRCRpALt+IEcpIsppE+	..................................LppLctpLssLcpcsAslspht.................shpARF.D.....+pLFps+uspLpshL-EAtsNLsuL+psVcpppL............QVAaL...AE+LsAQ....lpAl.sREh...u.....sh.......s.......LRph-sss....................................plsc..h..p....c+RhQH.Q-aE.RRLtpMlt-....R....+tpLu...p....sos......h.sEQQsL..p+.E.lps.hEuRLsRCRcALcKIEppls+hpR......................	1	7	24	57
+7275	PF07447	VP40		Matrix protein VP40	Vella Briffa B	anon	Pfam-B_22295 (release 10.0)	Family	This family contains viral VP40 matrix proteins that seem to be restricted to the Filoviridae. These play an important role in the assembly process of virus particles by interacting with cellular factors, cellular membranes, and the ribonuclearprotein particle complex. It has been shown that the N-terminal region of VP40 folds into a mixture of hexameric and octameric states - these may have distinct roles [1].	25.00	25.00	307.40	307.00	17.30	16.40	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.84	0.70	-5.36	2	35	2009-01-15 18:05:59	2003-09-19 17:02:16	7	1	20	4	0	33	0	287.30	60	91.60	CHANGED	M......susssYNshh..hs..Phtspshsp.h.uD.Lus.tu.sPs.s......sslshssph.usVspAFhLEAhlsl.uhschhhKtlPhWLPLGlhsph.YshspTsAAlhhuSYTlTpFs+.up.hVRVNRLGsGIPsHPLRhLR.GNQAFlQphVlP.s..sp.FTasLTsLhL.sQ.LPsssWpsppsthhsNsh+PulSlHPpL.PIlLPshhtpth+tpc.ssss.l.sI.shl.pL+l..ls.hpslhtIplPt.hhphhpGhh.p.tpspPll.h.hPc.hsL	................h.......susssYNshh..lsssPhus+GANphIsuDQLus.pG.TPs.s......ssLshDsphtGsVspAFhLEAhlsl.uhNchhlKtVPhWLPLGIhuphpYshspTsAALLhuSYTITpFs+sup.hVRVNRLGsGIPsHPLRhLR.GNQAFlQphVlP.s..sp.FTasLTsLhLssQhLPsssWpsSpsplhuNsh+PulSlHPpL.PIlLPshptpth+QHc.ssss.lhAIuslL+pL+l.plstppSlatIplPtshFphhpGhhppptpGSPll.h.sPc.hsL..	0	0	0	0
+7276	PF07448	Spp-24		Secreted phosphoprotein 24 (Spp-24)	Vella Briffa B	anon	Pfam-B_22318 (release 10.0)	Family	This family represents a conserved region approximately 140 residues long within secreted phosphoprotein 24 (Spp-24), which seems to be restricted to vertebrates. This is a non-collagenous protein found in bone that is related in sequence to the cystatin family of thiol protease inhibitors. This suggests that Spp-24 could function to modulate the thiol protease activities known to be involved in bone turnover. It is also possible that the intact form of Spp-24 found in bone could be a precursor to a biologically active peptide that coordinates an aspect of bone turnover [1].	25.00	25.00	28.00	27.00	21.00	18.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.84	0.71	-4.22	3	49	2012-10-01 19:28:07	2003-09-19 17:20:33	6	1	38	0	21	46	0	115.00	49	61.56	CHANGED	VLDEDoLVMNLEFoIQETTCRRESGtDPATCAFQRGYaVPTAVCRSTV+MSApQVQsVWARC+WSSSTSESsSSEEMIFGDMLGSH+pRNsYLLGLlsDES+GEQFYDRSlcIMRRsaPPGNRRYsNhp+RARVNoGFE	.............................lspsslsMsL-FuIRETsCp+-SGcDPsTCuFpRGaaVPoAsCRSoVclSupQVQsVa.s+CpWuo.oSESpS.SEE..Mhasshhtspp.R.pp..hshh.p...t.........................................................	0	1	2	5
+7277	PF07449	HyaE		Hydrogenase-1 expression protein HyaE	Vella Briffa B	anon	Pfam-B_21851 (release 10.0)	Family	This family contains bacterial hydrogenase-1 expression proteins approximately 120 residues long. This includes the E. coli protein HyaE, and the homologous proteins HoxO of R. eutropha and HupG of R. leguminosarum. Deletion of the hoxO gene in R. eutropha led to complete loss of the uptake [NiFe] hydrogenase activity, suggesting that it has a critical role in hydrogenase assembly [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.39	0.72	-4.15	9	623	2012-10-03 14:45:55	2003-09-25 11:36:21	6	4	503	19	47	938	96	106.10	58	75.57	CHANGED	LhpRLhsphGhshVD.ssslDcalss....tssuVLhluGDPsRhPEssDsAVlLPELhpsFssthhtullu..ttpE-tLusRFslh+hPoLlhhpcGpalGsLutlpDWsEY	.............................................LWQRhLsR.GWpPVs.tspLDDW.lsp.....sP.D...GV..VLLSS..DP..+..RT..PE.VSDN.P.V...MIuELL...R..E....FP.s.a..o......W...Q.VA.lA...DLEQSEAIGDRFsVhRFPATLVFTs......GpaRGsL.sGIHPWAEL........................	0	12	26	35
+7278	PF07450	HycH		Formate hydrogenlyase maturation protein HycH	Vella Briffa B	anon	Pfam-B_22086 (release 10.0)	Family	This family contains the bacterial formate hydrogenlyase maturation protein HycH, which is approximately 140 residues long. This may be required for the conversion of a precursor form of the large subunit of hydrogenlyase 3 into a mature form [1].	25.00	25.00	28.80	28.80	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.85	0.71	-4.05	19	787	2009-09-12 21:51:00	2003-09-25 12:51:46	6	2	548	0	50	216	2	129.60	66	95.41	CHANGED	scVlFapLs+KFVDpscs...sP-cApQVhYYSLAIGHHlGVlDCLcstLpCPhcpYppWlstLspG.EA+RKhpGlhpFGEIsIspsHsshLApA..........hstlststp.stppph..oppLlchLtsIppEPAIYLMV.R+p	........cVVF.pLs+KFlD.psDs...sPtcAQQVhYYSLAIGH.HlGVIDCLcsALsCPhsEY.sWlAsLEtG.-ARRKMtGV.KaGEIVIDhsHlshLApA..........FDcspsstT...SppQp..W..SphhlshLc-IpQEsAIYLMVRR.l....................	0	6	16	32
+7279	PF07451	SpoVAD		Stage V sporulation protein AD (SpoVAD)	Vella Briffa B	anon	Pfam-B_22130 (release 10.0)	Domain	This family contains the bacterial stage V sporulation protein AD (SpoVAD), which is approximately 340 residues long. This is one of six proteins encoded by the spoVA operon, which is transcribed exclusively in the forespore at about the time of dipicolinic acid (DPA) synthesis in the mother cell. The functions of the proteins encoded by the spoVA operon are unknown, but it has been suggested they are involved in DPA transport during sporulation [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.06	0.70	-5.99	41	555	2012-10-02 12:25:54	2003-09-25 13:15:53	6	4	414	6	107	452	34	322.00	51	97.04	CHANGED	G+QThhFps.PhIlusuolVGP+EGcGPLuchFDhlhpD.hhGc-SaEKAEpphhc-AsptAlpKuslppc..-lcallAGDLLNQlhuooFAARslsIPalGLYGACST.sEuLuLuuhll-uGaAchllsuTSSHauoAE+QFRaPhEYGsQ+PsTAQWTVTGAGAsllu....ppGs................s.PplTtsTlGKVlDhGlpDs.NMGuAMAPAAsDTIhpHFcDhspsPscYDLIlTGDLGplG+pIst-LL.cccGhclspp.apDCGlhIacp-.QsstuGGSGCGCSAlVhsGalhcphpcGchKRlLlVuTGALLSssShpQsESIPuIAHAVsIE	........................G+QThhF.ps.pPhIhuouolsGPcEucGPLuc.FDhla.cD.hhhGpco...aEpAEppLhp-AhppAlpKuslcps..-...Icahl....AG....DLlN......Qh.s......s...o......s...Fu......A.R...p.....l.......s...l...P..a....lGla...G..ACSTuhEuLAluuhhlsuGhAchllsusSSHpuoAE+QFRaPsEYGuQ+PsTApWTVTGAGAsllu......pp.s..s...................................................u..s+lTuATlG+VlDhGlsDPhNMGuAMAPAAsDTIppHhcDhphssspYDLIlTGDLGpVGppIsh-LLp.ccGhc....l.spt..apDCGlhIYc..ps.Q.s.VhAGGSGCuCSAsVshGalLpchpcGchp+lLlVATGALLSPhohQQtEoIPsIAHAVslE..................................................................................	0	54	86	92
+7280	PF07452	CHRD		CHRD domain	Hyvonen M	anon	Hyvonen M	Domain	CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins.  This family includes bacterial homologues. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin (Swiss:Q9H2X0) and Drosophila SOG (Swiss:Q24025). [1].	24.10	24.10	24.10	24.20	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.62	0.71	-3.49	101	936	2009-01-15 18:05:59	2003-09-25 15:53:44	7	50	447	0	346	766	59	117.80	24	54.16	CHANGED	pphsuhLsGsptss.sst...os...........usGpAhhslssss.........sLpa...........plp.hsGL.................ssssts+l.........s.tsppusllhsh................tsst....ssushp...s..lsstphpt.................LhsG....phalslpTpspss.GE..lRGplp	.................................h..h.u.Lsu..tpths..ssp.......op...............usG...pA.hhp...hssst..............pLpa...........plh..hpsl.....................................stsssscl..........ch........s.hsppus..llhtl..........................tsst.hsGsh...p.......t...lsstphpt...................................LhpG.....phalslpTpspPs..GE...lRGpl.......................................................	0	104	190	262
+7281	PF07453	NUMOD1		NUMOD1 domain	Pietrokovski S	anon	Pietrokovski S	Domain	This domain probably represents a DNA-binding helix-turn-helix based on its similarity to other families (Bateman A pers obs).	22.80	13.50	22.80	13.60	22.70	13.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.18	0.73	-7.71	0.73	-3.95	63	326	2012-10-04 14:01:12	2003-09-25 17:24:02	8	37	165	0	53	316	76	36.40	24	17.45	CHANGED	tslhlashssph....l...tpFsSlpcAActLslspss.Isphl	.................lh.hshssph....l....ppFpShpcAuctlslspss.Ipph.............	0	18	39	43
+7282	PF07454	SpoIIP		Stage II sporulation protein P (SpoIIP)	Vella Briffa B	anon	Pfam-B_21650 (release 10.0)	Family	This family contains the bacterial stage II sporulation protein P (SpoIIP) (approximately 350 residues long). It has been shown that a block in polar cytokinesis in Bacillus subtilis is mediated partly by transcription of spoIID, spoIIM and spoIIP. This inhibition of polar division is involved in the locking in of asymmetry after the formation of a polar septum during sporulation [1]. Engulfment in Bacillus subtilis is mediated by two complementary systems: the first includes the proteins SpoIID, SpoIIM and SpoIIP (DMP) which carry out the engulfment, and the second includes the SpoIIQ-SpoIIIAGH (Q-AH) zipper, that recruits other proteins to the septum in a second-phase of the engulfment. The course of events follows as the incorporation firstly of SpoIIB into the septum during division to serve directly or indirectly as a landmark for localising SpoIIM and then SpoIIP and SpoIID to the septum. SpoIIP and SpoIID interact together to form part of the DMP complex [3]. SpoIIP itself has been identified as an autolysin with peptidoglycan hydrolase activity [2].	20.10	20.10	20.50	20.40	19.70	18.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.86	0.70	-5.23	49	584	2012-10-02 19:46:12	2003-09-26 10:34:07	6	5	411	0	125	491	7	270.30	29	71.69	CHANGED	lphpD.....h.shhsp-lshhsthpsphhhstpts..sph..psssshp...pttpt.......................................sspcshVhIYHTHosESYh.P.....t..sssst.....p.slstVGctLsptL.cptGIsshpDcT..ha-h.....saspuYppSRpslpchLpppsshphllDlHRDu....................hp.ppth...sspIsGcshA+lhFVlGpp............sspacpNhphApplpshh-chYPG......Ls+Glhhts.t.....pYNQDLsspAlLlElGu.sNoh-EApposchlA-.lluc	.........................................................................................................................................th.....h.......t....t.tt.....pt.....p.....p...tp.p...................t.....ptt..........p...........................................................sssc.tlhIYHTHotESYh...P.h..........t.sssst.........phNlshVGchLpcpL.cppGIs.shp..DcT.......hpch.......saspSYptS+pslp......c......hLtpstslphhlDlHRDu....................hp...+.phs....oppIsGK.shA+lhFVlGpp................NssaccNhphApplpphhscpYPG......loRGlhhKs..t.....thYNQDLospulLIElGussNTh-EhpposcsLAcshu.p.........	1	67	105	113
+7283	PF07455	Psu		Phage polarity suppression protein (Psu)	Vella Briffa B	anon	Pfam-B_21666 (release 10.0)	Family	This family contains a number of phage polarity suppression proteins (Psu) (approximately 190 residues long). The Psu protein of bacteriophage P4 causes suppression of transcriptional polarity in Escherichia coli by overcoming Rho termination factor activity [1].	21.20	21.20	21.20	21.20	20.10	21.00	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.10	0.71	-4.82	5	269	2009-01-15 18:05:59	2003-09-26 11:05:58	6	1	159	\N	19	169	0	163.10	41	85.17	CHANGED	MTT.VTLQQAF-uCQNNKsAWLsRKsELAAAEQEYcELLhuG-css..sRRLQpLR-lIDVKKWElNQAAGRYIRSHEpVQ+ISIRDRLsDFMQQHGAELAAALAPELMGYppQsshl+psAlQ+SVDYLREALoVWLA......AGEKINYSAQDsDILTsIGFRPDAASRDDNREKFTPAQNhIYoRRRApLAup	...........................................................................................................................................................spphp..Rphl-VhcWplNpAAG+YIpoHctl.cIsh+stLpDFMQpHGsALsuALA..PpLM..G.pp.suhh..hsp..ulpcusshLR-ALhpaLs......pGs....hNYuh.-pD.ILsthGhtPDssuhpDspppaTPAQ..phha....pp+ps.lst...............................................	1	0	3	6
+7284	PF07456	Hpre_diP_synt_I		Heptaprenyl diphosphate synthase component I	Vella Briffa B	anon	Pfam-B_22032 (release 10.0)	Family	This family contains component I of bacterial heptaprenyl diphosphate synthase (EC:2.5.1.30) (approximately 170 residues long). This is one of the two dissociable subunits that form the enzyme, both of which are required for the catalysis of the biosynthesis of the side chain of menaquinone-7 [1].	30.00	30.00	30.30	30.30	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.62	0.71	-4.37	47	636	2012-10-03 02:46:00	2003-09-26 13:39:27	6	4	611	0	123	444	27	143.80	39	79.07	CHANGED	LsuhAlsltllEshIPhPh.h..PGsKLGLANllslluLhh.hu.h+pulhlsllRllluulhtGsh.o.sFhhShAGullShlsMhll.pph.......tcthShlGlSlhGAlhHNlGQLhlAuh.l.....lpshslhhYLPlLhlsGlloGhhhGlhuph....l	...LsA.ulllullEs.hIPhP.hsh..P.GsKLGLANllolluLah...hs.h+-uhhlhhlRl.lLssllsGsl.o.sFhaShuGulLShhsMhll.pph.h.........cp.lSllGlSssGuhhHNlGQLllAuh.l......hpshsl.h.h.YLPlLhhhGlloGlhlGlsush...........................	0	68	110	116
+7285	PF07457	DUF1516		Protein of unknown function (DUF1516)	Vella Briffa B	anon	Pfam-B_22136 (release 10.0)	Family	This family contains a number of hypothetical bacterial proteins of unknown function approximately 120 residues long.	29.90	29.90	30.10	31.50	29.70	29.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.67	0.72	-3.97	22	454	2009-01-15 18:05:59	2003-09-26 14:02:50	6	1	435	0	48	197	0	111.10	44	89.66	CHANGED	M...hH.....hHIhoWllhlILFhlAhhhasp...ts+tsKhlHMllRLhYllhlloGhhL...hlpt.......hsshthhhhlKhlhGlhlIuhhEhhls+ppK...t+sopshahhhllslllThhLG	.......M.lHlHIhSWVLulILFlssY.h.hSp...ts.hhKslHMlLRLFhlLsllSGFhl...llpph.....ssuusHMLhsLKMLsGlhVlGlMEhsluK+K+....pc.tops.hahlhI.sllllThhLG.........	0	11	30	41
+7286	PF07458	SPAN-X		Sperm protein associated with nucleus, mapped to X chromosome	Vella Briffa B	anon	Pfam-B_22197 (release 10.0)	Family	This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumours but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic [1].	21.90	21.90	23.60	22.40	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.32	0.72	-3.76	9	92	2009-01-15 18:05:59	2003-09-26 15:59:36	7	2	12	0	10	83	1	92.30	49	79.27	CHANGED	M-p.pSSssG.KRpoPC-SNp.tN-pM.ETPstD.sPcPu.KKhKTSE.ST.llVlpYR+phKI...sSspL.NDpSpENsINPlQ.EE-Ehh-hpsEospp	................................M-p.pSSssG..KRp.sPC-SNp.tN.......-......p......M..ETPsts.sP.p.u.KKhKTSE.sT.llVhpYR+shKh...ssspL.NDp.upENpINPlQ.EE-Ehh-...t.st.c.......................................................................................................................	0	10	10	10
+7287	PF07459	CTX_RstB		CTX phage RstB protein	Vella Briffa B	anon	Pfam-B_22203 (release 10.0)	Family	This family contains a number of RstB proteins approximately 120 residues long, including RstB1 and RstB2, from the Vibrio cholerae phage CTX. Functional analyses indicate that rstB2 is required for integration of the CTXphi phage into the V. cholerae chromosome [1].	20.30	20.30	20.90	23.30	18.50	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.59	0.71	-4.23	2	78	2009-01-15 18:05:59	2003-09-26 16:48:33	6	1	49	0	7	34	0	109.50	79	94.27	CHANGED	MKl.........VsFGhSpS.GluppsstPY.I.sLFVGKPIRQWKsDKG.s.s.Ghpp.El.F.SsDthhpKlcphAFPsLVphcsEP.PEDPo+NllIshpVlCoLaDsVPtsK.	.............MKSRFVVFGASHSEGVS.KTG..APYLIPVL.FVGKPIRQWKNDKGQCLTFGLQHQEV..KFVS.SDAMTRKLE..Q..T..A..FPVLVTFDNEPDPEDPSRNLVIDYQVVCSLFDNVPGGKP....................	0	3	4	5
+7288	PF07460	NUMOD3		NUMOD3 motif (2 copies)	Pietrokovski S	anon	Pietrokovski S	Motif	NUMOD3 is a DNA-binding motif found in homing endonucleases and related proteins. It occurs on its own or in tandem repeats in GIY-YIG (Pfam:PF01541) and HTH proteins. It constitutes a beta-turn-loop-helix subregion of the the DNA-binding domain of I-TevI homing endonuclease (Swiss:P13299) [1].	20.40	9.30	20.40	9.30	20.30	9.20	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.98	0.72	-4.06	25	485	2009-12-15 13:13:21	2003-09-27 14:40:31	6	26	140	2	73	456	321	32.80	29	23.99	CHANGED	hGtK+oEEoKpKhSp........h.ttshhGKp+o-Eo.KpKlSc	................................h.hoc-s+p+hSp.................t.tps.hhGKp.t...otEs.+thhp................	0	37	62	68
+7289	PF07461	NADase_NGA		Nicotine adenine dinucleotide glycohydrolase (NADase)	Moxon SJ	anon	Pfam-B_21586 (release 10.0)	Family	This family consists of several bacterial nicotine adenine dinucleotide glycohydrolase (NGA) proteins which appear to be specific to Streptococcus pyogenes. NAD glycohydrolase (NADase) is a potential virulence factor. Streptococcal NADase may contribute to virulence by its ability to cleave beta-NAD at the ribose-nicotinamide bond, depleting intracellular NAD pools and producing the potent vasoactive compound nicotinamide [1].	28.50	28.50	29.00	31.80	25.60	28.40	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.43	0.70	-5.80	2	89	2009-01-15 18:05:59	2003-09-29 10:54:18	6	1	32	2	4	78	0	423.80	87	95.30	CHANGED	MRNKKVTLAHIVAKTSVAIALAGAMGSSLLANSTTYAVSGKENKKSDVKYETTKVMEANATSSKEDNHVMHTLDGSMSTVWEENSPGGGVGEVLSYKFsSPM+IGRILIVNGDTSSKENYYKKNRIAKADVKYYNtNKLVLFpKIELGDTYTKKPHHIEIDKKLDVDRIDIEVTEVHQGQNKDILALSEVTFGNhERDlFEKKFKEIKDKWVTDKQADEFIETADKYADKAlQMSAVASRAEYYRMYVSRKYHYKKEFVEKLKQVYKESGASHVTSKKDLMLAFDDAK+KSTIGRQENGLFVTSFAEDMALLFTDQGKLKSADQIENIKGVDSGKYSDGVYQYEYDSELTKNIDKLGYIRTASGDTPGANSLNIPGCQTWSGKHIENSESELIFPSISVKDLKSKAVLAEIDAKGYFEIIDPTIIAPNGDHKKVTGRFKIKKMQDR	..........................MRNKKVTLAHIVAKTSVAIALAGAMGSSLLANSTTYAVSGKENKKS..DVKY.........ET.TKV..MEANATSSKEDNHVM...HTLDGSMSTVWEENSPGG.GVGEVLSYKFASPM+IGRILIVNGDTSSKENYYKKNRIAKADVKYYNGNKLVLFQKIELGDTYTKKPHHIEIDKKLDVDRIDIEVTEVHQGQNKDILALSEVTFGNhERDlFEKKFKEI...KDKWVTDKQADEFIETADKYADKAVQMSAVASRAEYYRMYVSRKYHYKKEFVEKLKQVYKESGASHVTSKKDLM.LAFDDAK+KSTIGR..Q...ENGLFVTSFAEDMALLFTDQGKLKSADQIENIKGVDSGKYSDGVYQYEYDSELTKNIDKLGYIRTASGDTPGANSLNIPGCQTWSGKHIENSESELIFPSISVKDLKSKAVLAEIDAKGYFEIIDPTIIAPNGDH.KKVTGRFKIKKMQDR.....................................................	0	1	2	2
+7290	PF07462	MSP1_C		Merozoite surface protein 1 (MSP1) C-terminus	Moxon SJ	anon	Pfam-B_21542 (release 10.0)	Family	This family represents the C-terminal region of merozoite surface protein 1 (MSP1) which are found in a number of Plasmodium species. MSP-1 is a 200-kDa protein expressed on the surface of the P. vivax merozoite. MSP-1 of Plasmodium species is synthesised as a high-molecular-weight precursor and then processed into several fragments. At the time of red cell invasion by the merozoite, only the 19-kDa C-terminal fragment (MSP-119), which contains two epidermal growth factor-like domains, remains on the surface. Antibodies against MSP-119 inhibit merozoite entry into red cells, and immunisation with MSP-119 protects monkeys from challenging infections. Hence, MSP-119 is considered a promising vaccine candidate [1].	20.40	20.40	20.50	20.40	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.96	0.70	-6.12	4	835	2009-01-15 18:05:59	2003-09-29 11:07:15	6	6	34	0	10	628	1	341.40	56	39.29	CHANGED	Shss+uESE--h.ssshEl-phYcsaLpplDs..NspFhpFlKSKK-lIsuLT.pKhNtLhhEIt+LK-h.ph.aD+YhKYKLKLERLapK+cpIpsuppQIKcLolLKs+L.+Rpp.lNssa.VLpsassFFNK+REAEKp.V-NsLKNT-hLLKYYKARsKYasuEusPLKTLocsSlp+EsNYLplEKFRshSRLEhRLpKNIpLGKE+ISYlSuGLHHVhpEhKEllKNKsYTGposs-NsscVpcAhcpYcELLPKssTtpAssss.ssTPsssssussstusssuuuuGuuuGpssssTstpl...G.utss......................Vlsh.ussDDDD--hDQlsoGpupstp.csILsAFcsE.-hlYhKsLussYKSlKKph.+chsshppslsshLNs+LcKRN.FL-VLsp-Ls.FKclSoNcYlI+sPYpLLDs-KKcK.lhshKYhtcuVscDIcTAsDGIpaaNKMlELYKspLsAVpcQIctltst.ss..c-cKK......................KYlPhhpsLcsLYEollsps--Yh-sLpp+lsshplEKsEh-	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................A..o...s..-..llssh.s-Y-VlY.LKPLAGMYKoIKKQLENHVsAFNTNITDMLDSRLKKRNYFL-VLsSDLNPFKYSS.SGEYIIKDPYKLLDLEKKKKLlGSYKYIusSIDhDlsTANDGluYYNKMt-LYKscLsuVpppIKclEsph.t..-ch..cKh.........spsspss.p.sp.hAcKtE.cKYLPFLNSlpKEYEoLVsKlsoYopN.LKKhIsNCQlEK+EAE............................................	2	1	2	7
+7291	PF07463	NUMOD4		NUMOD4 motif	Pietrokovski S	anon	Pietrokovski S	Motif	NUMOD4 is a putative DNA-binding motif found in homing endonucleases and related proteins [1].	23.40	23.40	23.50	23.50	23.00	23.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.47	0.72	-4.08	55	364	2009-09-11 07:03:11	2003-09-29 11:41:44	6	21	293	1	46	303	100	52.20	30	27.43	CHANGED	EhWKsI...G.acs...YpVSshGRV+S..................hpps+lLp.ths...sGY..hhVsLt.ps	.......EhW+sIt.....u..a-s.....Ypl..SshG.+V+o..................htps+lL+sphs..t..sGYhhVsLh...........................................................	0	13	30	37
+7292	PF07464	ApoLp-III		Apolipophorin-III precursor (apoLp-III)	Moxon SJ	anon	Pfam-B_31170 (release 10.0)	Family	This family consists of several insect apolipoprotein-III sequences. Exchangeable apolipoproteins constitute a functionally important family of proteins that play critical roles in lipid transport and lipoprotein metabolism. Apolipophorin III (apoLp-III) is a prototypical exchangeable apolipoprotein found in many insect species that functions in transport of diacylglycerol (DAG) from the fat body lipid storage depot to flight muscles in the adult life stage [1].	31.00	31.00	31.00	31.50	30.90	30.90	hmmbuild  --amino -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.16	0.71	-4.20	8	45	2009-01-15 18:05:59	2003-09-29 14:54:15	6	2	36	1	18	50	0	143.30	27	77.83	CHANGED	lEKHAtEFQKTFSEQhNulsNS..KssQ-VNKAlK-GSDSVLQQLssluoSLQuAlsDANGKAKEALEQsRpNlE+TAEELRKAHPDVE+pAspLRD+LQAAVQuTlQEoQKLAKEVuuNh-ETN-KLAPpIKpAYDD...FVKpsEEVQKKlHEAAoKQ	...............................pht-h.pshppphpphhs.......pssp-lscslK-socshlpplpshtsslpstlpc.ssschcpslcphppplpcTsccLpc..s.pP-lpcpAspLpp+lQsulQshspEspKluKclupssppss-cLsstlKpsaDs...hscsspclpcclppAsp..............	0	4	8	17
+7293	PF07465	PsaM		Photosystem I protein M (PsaM)	Moxon SJ	anon	Pfam-B_21548 (release 10.0)	Family	This family consists of several plant and cyanobacterial photosystem I protein M (PsaM) sequences. PsaM forms part of the photosystem I complex and its binding is stabilised by PsaI [1].	20.80	20.80	20.90	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.52	0.72	-7.03	0.72	-4.34	40	300	2009-01-15 18:05:59	2003-09-29 15:43:26	8	1	285	2	33	181	1	28.70	48	91.33	CHANGED	IoDoQIalALllALlsulLAlRLGppLY+	............l.-sQlllAL..hlAhhsulLAl+LGpsLYp..	0	12	24	31
+7294	PF07466	DUF1517		Protein of unknown function (DUF1517)	Moxon SJ	anon	Pfam-B_22018 (release 10.0)	Family	This family consists of several hypothetical glycine rich plant and bacterial proteins of around 300 residues in length. The function of this family is unknown.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.98	0.70	-5.42	27	295	2009-01-15 18:05:59	2003-09-29 15:46:33	6	6	196	0	143	297	48	193.10	20	68.03	CHANGED	tAtSGGRIGGGSFp.uP.......SsPpo.ss.suuhh..................GGGhGaPFllPh......aGhGG.G..GLFuhLlhhulsshllpshRssttt...........ssttst.hssstVolsplQVGLLApA+sLQpDLpplAtpADTsossGLppVLQEsoLALLRpP-hWVYusscss.pssh....suAEu....pFNpLolpERSKhspEohSNlssppppsstst.ss.s.t.........-sssEYIlVTlLVAucupl.pLPt.lsous-LRpALptLGulsuscLlAlEVlWoPpscGDsLot-ELlssYPpLphL	.....................................................................................h....uGt..GGt.uFt..ts.............s.ss.pt..t.tsss......................t......................us...hhs...hs.hhsh...............................hGhuh....t....t...h...hs.h.l....lhhhlshhlh.thhpt..............................................................................................................................................................................................................................................................................................................................................................................................	1	31	88	132
+7295	PF07467	BLIP		Beta-lactamase inhibitor (BLIP)	Finn RD	anon	Pfam-B_41444 (release 10.0)	Family	The structure of BLIP reveals two structural domains, which form a polar, concave surface that docks onto a predominantly polar, convex protrusion on beta-lactamase. The ability of BLIP to adapt to a variety of class A beta-lactamases is thought to be due to flexibility between these two domains [1].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.16	0.71	-4.63	3	21	2012-10-01 23:09:26	2003-09-29 16:55:43	6	1	15	29	4	43	0	132.40	29	91.48	CHANGED	VK.RluRouluLsAAAGAVLATAoSApAsoGFTuEKYsQIQFGMTRspVW-IAGAEtuC-TGGshGDSIlCasc.uGDYuPYGsFuFTuA...uKLhSKRQEcLasAssPTl+LA+YN+TslGMTEAQlWAAVPpDSCoohuEpYPNWPATsGspccYsC.....sSuTGhFsPSAaFaFTDGVLTuRpQpsL	.................h.....................hll..A..sshuhs.AsothTsEpYppIphGMspsEVhsllG..ut.ss...C.s-..ss..h..................................................................................................................................................................................................	1	1	1	3
+7296	PF07468	Agglutinin		Agglutinin	Finn RD	anon	Pfam-B_57133 (release 10.0)	Family	\N	25.00	25.00	27.50	25.80	23.20	17.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.00	0.71	-4.23	2	39	2012-10-02 19:42:32	2003-10-03 15:43:28	6	5	9	8	23	50	0	139.20	29	55.88	CHANGED	hthPhhhshhpsNNtKYLth.o..IpQhshLQFuhDpl.DPhstaph.s..T.sGhlpIKSpYhNKahhh.osN..WIhssuN-PcE..oN.AssLF+s...-.tshphlpLLphQhsaahcpaTsGts.Flshh.Atop.lDpsu..lhclI-	..................................................hlhhpssNscYLphhs....hp..thshLpFuu--lsDPhstapl.s..s..tcG..hV+I+ssahsKaW+.c.....o...sN........WIhAsus-scp..os.ssTLFcPlhl.-.tphp.hlthpphttspaspphs......hsCL.Ass..tp.p...............................................	0	0	11	23
+7297	PF07469	DUF1518		Domain of unknown function (DUF1518) 	Finn RD	anon	Pfam-B_1525 (release 10.0)	Domain	This domain, which is usually found tandemly repeated, is found various receptor co-activating proteins.	25.00	25.00	28.90	28.90	24.20	23.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.85	0.72	-3.82	17	247	2009-01-15 18:05:59	2003-10-06 13:27:18	7	13	39	0	91	216	0	57.30	44	5.65	CHANGED	uhsuthussthPQussQQFPasPNYGhuQQs-PuFssuhSP.SshMSsphu.oQSsMh	...uhsuphusPthPQussQQFPYPPNYG..h..up..Qs-PuFsssh.SP.oshhssphssoQssMh...........	0	4	9	29
+7298	PF07470	Glyco_hydro_88		Glycosyl Hydrolase Family 88	Finn RD	anon	Pfam-B_10896 (release 10.0)	Family	Unsaturated glucuronyl hydrolase catalyses the hydrolytic release of  unsaturated glucuronic acids from oligosaccharides (EC:3.2.1.-) produced by the reactions of polysaccharide lyases [1]. 	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.22	0.70	-5.40	19	2447	2012-10-03 02:33:51	2003-10-06 14:06:07	8	26	1025	25	672	2054	111	336.70	21	81.37	CHANGED	hhc+hspthh.c.s..........h......c........WspGlhhtG.hh.tsa-hTtccc....Yhphsps..........ascphhccssp..................hplDphshGhhh....hh....lYchst.Dpchhtsshpht-.lltphs+htcGshh+.....tph..hphW.............lDsLaMusPhhhph....uphhs-...cah-cshppahhptcp.................hhDscsGLaa+uac....pspp.hus........hWuRupGWhhhulschlch......LPp.pcss+p.lhplhpshs.ps.lt+hQc.psGhWapllccss...shhEoSuoAhhlYulh+ul............ppGh....l.scpYtpssp+uacullcp...........lpc-Gphhlppsssssuhst............YtshshtpspsaG.GhhlhAhhEhh+hh	...........................................................................................................h......................................tt...p..............Ws.pGhhhhG...hh..hha....c....ho....t....c....pp..............hh.ph..s.pp.........................hh.p.p.h..h..t..phsp.............................phpl.s.p...h..s.h.G.h..h.h.............hh............hY....c.....h.........s........s....s........t........ph..tp.h...h..h.phA-......hhp...p..h.........p.........t.....p.G...s..h..hp...............................tp.t..p.tpha.............................lDsl..hM..sl....h..L.h.hh...................uphs....s..c.t......ca.h.-..Ahpphh..hp..hpp..................................hh.D.s...c...o.....Ghh..h.+..uhs........t..p.u..h......p..s.us................................hWuRGpuWshhuh..sthhch...............l.......p....p........p......s......t........t...p.......h.......h.......h.......p......h.hpt....hh..pt..l.......h..c......h...............c....p........s..u.....h...W.....p........h............h....h........s.....c.......s...........s.......................s.........................h-oSAoA.hh...shu....l...h..p..tl...................................pp.th..............h.......t.....p...p....Y.....t...p....s....s...pc....t...hpulhpp...................hs.t....s....G..p............l..t...t.s.hhh.pu...t.................................p.sh...s...h..s.s................aG.shhal.Ahhch....h..............................................................................................................................................................................	0	272	506	604
+7299	PF07471	Phage_Nu1		Phage DNA packaging protein Nu1	Finn RD	anon	Pfam-B_11430 (release 10.0)	Family	Terminase, the DNA packaging enzyme of bacteriophage lambda, is a  heteromultimer composed of subunits Nu1 and A.  The smaller  Nu1 terminase subunit has  a low-affinity ATPase stimulated by non-specific DNA [1]. 	30.00	30.00	30.30	30.20	29.90	29.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.96	0.71	-4.77	11	762	2010-01-12 09:52:22	2003-10-06 14:22:59	7	4	374	2	31	345	35	138.20	50	83.26	CHANGED	McVNKKpLA-IFGsulRTIppWQcQGhPVl+GGGKGsEslaDoAuVI+WYA-R-AEIENEKLR+EVEELRtAuEsDLpPGTI-YER+RLTRAQADAQELKNA+-suEVVETAFCTFVLSRIAuEIuSILDGIPLSlQRRF..PELENRHlDFLKpDIIKAMNKAAA	.................................................................lNK+phAc.hsss.pshppW.t....p....Ps.p.......K.G..EshaDsAssIp...hpR.cs..p..c..s..p+Lp.c-.ht-...lct..s.s.pt....D..ps..spl.h..tRaRL.TcAQA-AQE..LKNs.+-pucVl-TsFChFsLS+lAtpIuSILD.u.lPLohQRpF..P-LpsRHlDhLKp-IhKAhNpuA.........................................................................	0	8	18	28
+7300	PF07472	PA-IIL		Fucose-binding lectin II (PA-IIL)	Finn RD	anon	Pfam-B_17609 (release 10.0)	Family	In Pseudomonas aeruginosa the fucose-binding lectin II (PA-IIL) contributes to the pathogenic virulence of the bacterium. PA-IIL functions as a tetramer when binding fucose. Each monomer is comprised of a nine-stranded, antiparallel beta-sandwich arrangement and contains two calcium cations that mediate the binding of fucose in a recognition mode unique among carbohydrate-protein interactions [1].	20.90	20.90	20.90	22.40	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.15	0.72	-3.83	12	85	2009-01-15 18:05:59	2003-10-06 15:00:50	6	5	53	100	25	63	2	108.60	48	54.85	CHANGED	FpLPsshcFGlTAasNou.tpQTlcValDDp.t..sTasGpGssss.huTpslsSG.sG+Vplpl.usGKPScLtup.ssLss........KsshullGuEsGsDsD..YNDulVlLNWPL	...........FsLPsNhpFGlTAasNou.spQTIcValssssp..ATFpGsuoss.....s........luTplLNSG..sGKVplpVosNG..KPScLsSpQsslss........cssFu..lVGSEDGoDsD..YNDulVVLNWPL....	0	2	9	15
+7301	PF07473	Toxin_11		Spasmodic peptide gm9a	Moxon SJ	anon	Pfam-B_90829 (release 10.0)	Family	This family consists of several spasmodic peptide gm9a sequences. Conotoxin gm9a is a putative 27-residue polypeptide encoded by Conus gloriamaris and is known to be a homologue of the "spasmodic peptide", tx9a, isolated from the venom of the mollusk-hunting cone shell Conus textile [1]. Upon injection of this venom component, normal mice are converted into behavioural phenocopies of a well-known mutant, the spasmodic mouse [2].	25.00	25.00	33.40	33.40	21.50	20.30	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.67	0.72	-4.02	2	4	2012-10-01 22:06:18	2003-10-06 16:07:17	6	1	4	1	0	5	0	27.50	46	37.54	CHANGED	.CspuCpS.scCsp+ChCp.ctpsshpt	..CNNSCQpHScCsSHClCphctCssVNt	0	0	0	0
+7302	PF07474	G2F		G2F domain	Bateman A	anon	Bateman A	Domain	Nidogen, an invariant component of basement membranes, is a multifunctional protein that interacts with most other major basement membrane proteins. The G2 fragment or (G2F domain) contains binding sites for collagen IV and perlecan. The structure is composed of an 11-stranded beta-barrel with a central helix. This domain is structurally related to that of green fluorescent protein Pfam:PF01353. A large surface patch on the beta-barrel is conserved in all metazoan nidogens.	23.50	23.50	23.60	25.40	21.10	23.40	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.16	0.71	-4.93	5	296	2012-10-01 21:32:51	2003-10-27 12:53:42	7	164	81	2	160	235	0	182.50	35	9.46	CHANGED	cGuPQRlNGpVpGpIpVls.c...hslsFsssDLHuYlVos-GRuaTAIS.slPpsLGpuLpPlssIGGllGWLFAcEp.ssuhNGFoLTGGpFsRcspVcF..csG..clpIcQpacGlDs-.....saLsl+hslcGpVPpIsssuoVpIcDYoEhYppotsGllTSpSTRsaTVcs.....uu.spTasYolDQTITF-pCpc+.scls	......................................................GsPpRspGpltGplpss...p....hslsh.ssslps.sssssuph.aouIo.....p.lPpslG..uhhsLsslhuslhWhhAhE..ssshNGFo....lT...G..utFp+pspVpF...tsG...EhLplsQphcGLDsc.......shLhlcs.lpGpV.Pplsssuslplp.sYpE.Yh.o.su........lhutSoRpas.l.st...........tshsYphppsIpYppsttt....s................................	0	26	38	83
+7303	PF07475	Hpr_kinase_C		HPr Serine kinase C-terminal domain	Bashton M, Bateman A, Moxon SJ	anon	COGs	Domain	This family represents the C terminal kinase domain of Hpr Serine/threonine kinase PtsK.  This kinase is  the sensor in a multicomponent phosphorelay system in control of carbon  catabolic repression in bacteria [1].  This kinase in unusual in that it  recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating  enzymes [1]. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller [2].	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.79	0.71	-4.95	81	2208	2012-10-02 15:24:17	2003-10-28 16:53:30	7	7	2083	29	470	1375	236	159.20	43	53.76	CHANGED	ppLAsppslHGVLlDVaGlGVLIpGcSGlGKSEsALELlcRGH.RLVADDsV-lpchsppt.LhGp.uPcllcchlElRGlGIIslpsLFGhsul+spppIpLllpLppWcpp..ppaDRLGh-.ppptcILslclPplplPVcsGRNlAlIIEsAAhNa+hKphG.asuscpFpcRl	...................t.pLA.psolHG.VLlDla.Gh....G....VLIpG-SGlGKSEsAL........E........L....l.......c......R......G......H.......R......LVADD.........tV.-l...h.........p...h.sc.p............p...Lh.Gp........s...P..c...l...l.ca....L.l...E.I..RGlGIIsVhsLaGsuul+sppplpLslpLcpappp........ctaDRLG...p.p..p..p.hclh.s.splsplplPV+sGRNlulllEsAAhNaRhp..hG.hsssppFtcR...................................................................	0	158	314	385
+7304	PF07476	MAAL_C		Methylaspartate ammonia-lyase C-terminus	Bateman A, Moxon SJ	anon	COG3799	Family	Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the C-terminal region of Methylaspartate ammonia-lyase and contains a TIM barrel fold similar to the Pfam:PF01188. This family represents the catalytic domain and contains a metal binding site [2].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.55	0.70	-5.45	14	185	2012-10-02 01:07:48	2003-10-28 16:58:51	6	4	176	12	41	2518	572	245.40	60	60.15	CHANGED	slshcslPlFuQoGD-RYhNsDKhIlKcs-VLPHuLhNsV-.KlG.cGEcLh-YlpWLppRlhpL.uscsYpPhlHlDVYGTlGthFss..Dhc+hs-YLupLccuAtPatLpIEGPhDsGs+ttQIctLstLRptLccpGlsVclVADEWCNThEDI+tFsDupAucMVQIKTPDLGGlsNol-AlLYC+c+GlGAYlGGoCNETDhSAclssHlALAspPsQhLuKPGMGlDEGlMIlpNEMpRslAlhcp	.....................................................................................................s..sEsIPlFGQSGDDRYlsVDKMILKGlDVLPHALINNVE-KLGh+GEKLtEYVcWLu-RIlsh.RsuscY.+.PsLHI.D.V.....YGT...IGllF-h..Ds......hRsApYIAoL.EcpApshs.L.h.I.EG.PlDAG.sK.s.cQIchLsuls.ccLs.+hGos.....V+IVA.DE.W.C.NT.a.p.D....I.h.-.F.sDAsusHMVQIKTPDLG.uIcNllDAVLYCpp+uhpAY.pGGTCNETDlSARsCVHVALAsRPhpMLsKPGMGFDEGl.IVaNEMNRTlALLp.s...........................................	2	16	26	35
+7305	PF07477	Glyco_hydro_67C		Glycosyl hydrolase family 67 C-terminus	Finn RD, Moxon SJ	anon	CAZY	Domain	Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the C terminal region of alpha-glucuronidase which is mainly alpha-helical. It wraps around the catalytic domain (Pfam:PF07488), making additional interactions both with the N-terminal domain (Pfam:PF03648) of its parent monomer and also forming the majority of the dimer-surface with the equivalent C-terminal domain of the other monomer of the dimer [1].	20.30	20.30	20.80	28.80	19.30	19.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.52	0.70	-4.95	38	293	2010-01-08 16:36:07	2003-10-29 13:35:56	7	7	257	17	125	306	20	220.20	42	31.06	CHANGED	oGphhAQANhYuaGRLAWsPshsocpIscEWlRhTF.......us.cpcVlcslsp............hhhpSapAa.sY.ssPLGlpahsshs....a.HYGPsPtsp-tss......Wus..YH+ADcsGIGhDRT.poGoG...hsuQYss.lAcha-slcTsP--LLLWFHHVPasa+L+SG+TllQclYcp+acGscpVpshhpsWcuLcutlDscRapcVtt+LphQtpcAhhWRDuhssYFhphSG..IP-thsRst.a	..................................sGp.hAQANhYAaGRLAWsPslsucpIscEWl+hTF...............us.-.tpl.....lcslpp................hhhpShcsh.sY.psPLGltahhs.s.....+..HYGPsPts.c.hst....................Wss......YH+ADppGIGhDRT.uo..G..os...hsuQYhs.lspha-slposP-cLLLaFHHVPasa+L+S..G+T...lhpclhspahcGlcpspphhppWp.s.Lcs..h..l...D.s..........c..........RapcVtp+LphQtccAh.WRDshssYF.phSG..IPsthtR..............	0	42	84	108
+7306	PF07478	Dala_Dala_lig_C		D-ala D-ala ligase C-terminus	Bateman A, Moxon SJ	anon	PSI-BLAST 2dln	Family	This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF) [3].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.90	0.71	-4.93	18	6597	2012-10-10 13:17:03	2003-10-29 13:51:30	8	33	4445	68	1275	21237	8280	190.70	33	59.00	CHANGED	LhpssGlssssahslp+pchppts......htph.tpLGaPlFVKPAptGSSlGloKVpst-ELpsAlcpAhpYDpcVllEcsl.sGcElpsulLG..Nts.hplussscIthss......uFYDYcsKY....s.ssuphhlPAsLstphppplpchAhcsY+sLus+GhARlDFFL.spcGplhLNElNThPGFTshShaPphhtssGlsascLlspLlp	............................................................................................................hpstGl.sh.ss..a..h...s.l.pp.sp.....p.t....................t.h.....p..p....L..s.h.....P.l.h.VK..P..u..p....t..G..S........S..l.....G.....l.....o....K.....V.......p....s.......p.......p.......p......L.......p.......t........A......l........c..........h.........A...........h..........p............a...........D.........p..............c.............V......l......l..Ep.hl.....s.G...........c......El...p...s...u....l..L.G...........p....tt......sp...s...h......s...s...s..E...I..h.h..ss...........................sF...Y..D...Y...-..u.K...Y...........................................s.....s.....p...........s.....p...h.........h.......h......P.........A.....p.................l.......s......s.........c.........h..t...p...p.....l..pp..hAhp.Aa..p.....s.....L.......s......s....p.......G....h...u..R.l...D..................h.....h........l.......s................t............c.........s........p.....h......h..l.E..lN.....T.hP.....G..h.....T.........s.....h.........S.h.........h.Ph.........h.........h.p.s.s.G.lsaspLlpcll......................................................................................................................	0	456	861	1094
+7307	PF07479	NAD_Gly3P_dh_C		NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	Finn RD, Bateman A, Moxon SJ	anon	Prosite	Domain	NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain [2].	25.00	25.00	27.20	26.30	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.81	0.71	-4.49	27	5512	2012-10-02 19:36:47	2003-10-29 14:12:16	9	20	4754	22	1400	3895	2018	143.50	41	42.43	CHANGED	sDlhGVElsGALKNVlAlAsGhsDG......luhG.....sNsKuullphGLhEhp+huthhssssp....Taht.sGluDLlsTChu..uRNp+hGptlu+s...pshcplpcph.......GthlpGstTscplhplhpppsl...............chPlhpslYpllhpthpspchlppL	.............sDllGVEluGAlK.............NllAluAGhs.cG...........l.G..hG..........sNu+.......AALlTRGL......sEhsRlG........s...s...h...Gupst.................TF.h.G.LuG..lGDLllTCou.....S..R............Nh+hGhtLGpG...............pslcph.pph.....................GtVlEGh....tosc...sl....h.p..lAc.c..h.sl...............cMPIspslap.lLap.stssccsh...h...........................	0	469	881	1177
+7309	PF07481	DUF1521		Domain of Unknown Function (DUF1521)	Yeats C	anon	Yeats C	Family	This family of unknown function is found in a limited  set of Bradyrhizobium proteins. There appears to be a periodic -DG- motif in it.	21.00	21.00	22.40	22.20	20.60	19.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.22	0.71	-4.55	5	27	2009-01-15 18:05:59	2003-11-03 12:43:51	6	2	16	0	10	27	0	155.60	39	56.14	CHANGED	WSH.EV+DGKATIcLGDKYoIslDEKDGThplRNsQTG+lT+I+GDPHVDANGDGKcDFDFKKsMTFQLDDGTKITVDTVsYGp..GcTlASKLTITNGDNAMVVEGLGDccDGKNNL+VTQSNAGRTLDpLTsDGAQTIaEtoGpGWVDs.oG+tVTQAsIstsEsssssushp	....................ppupupIphsDtYoIpss-psushplpNsp.TGcsT.plaGDPHVDssGDGcssFDFK+shTFpL-DGTKITVsTssaGs..GtTloS+LTITsGcs.uhhVpGlscsc..pssLplppu.ssGhhlD.hssDG.phh.p..sstGal..s...tGt...ssQt.hs.sc.........t......................................................	0	5	6	8
+7310	PF07482	DUF1522		Domain of Unknown Function (DUF1522)	Yeats C	anon	Yeats C	Family	\N	25.00	25.00	25.00	111.30	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.40	0.72	-3.90	20	54	2009-01-15 18:05:59	2003-11-03 16:03:44	6	2	9	0	40	58	0	111.70	54	27.03	CHANGED	oTLsVNGKTITFKsussPsuu...slssGSGls..GNllTDGsGNSTVYLss......ATVsDlLsAIDLAoGVpoATl.usGsATlussu.....GssuS...hsuuGsLsLsTuTGuDLSIo.Gsush	.oTLsVNGKTITFKsussPsus...slsoGoGls..GNlhTDGsGNSTVYLts......uTVsDVLpAIDLAoGV+oAol.usGsATluTus.....GsssS...ssuuGtlpLsououADLolTGsush.....	0	8	14	20
+7311	PF07483	W_rich_C		Tryptophan-rich Synechocystis species C-terminal domain	Yeats C	anon	Yeats C	Family	This domain is found at the C-terminus, normally between 2-3 copies, of a range of Synechocystis membrane proteins. This domain is fairly tryptophan rich as well. 	20.70	20.70	21.20	20.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.52	0.72	-4.37	14	123	2009-01-15 18:05:59	2003-11-03 16:47:07	6	23	22	0	33	93	105	104.40	32	17.49	CHANGED	s.sTSLlttsssYahs.hssGosstLKYsGtshssGpFGshsPluA.pTusG.apVsWpssuTspaohWsTDuNGNahSp.oshVsGsShps.shEssFtpDlNGDGslG	............................thulltt..shahs.husssssslKat.G.ps.hssuphGsWpsl..uA.ET.ssGh.QVLWp..sss...ssphsVWsoDuNhNalu..Ssshss.sSsphhshEssFphDlNsDuhlG...................	0	13	20	20
+7312	PF07484	Collar		Phage Tail Collar Domain	Yeats C	anon	Yeats C	Domain	This region is occasionally found in conjunction with Pfam:PF03335. Most of the family appear to be phage tail proteins; however some appear to be involved in other processes. For instance Swiss:Q03314 from Rhizobium leguminosarum may be involved in plant-microbe interactions ([1]). A related protein Swiss:Q9L3N1 is involved in the pathogenicity of Microcystis aeruginosa. The finding of this family in a structural component of the phage tail fibre baseplate (Swiss:P10930) suggests that its function is structural rather than enzymatic. Structural studies show this region consists of a helix and a loop ([2]) and three beta-strands. This alignment does not catch the third strand as it is separated from the rest of the structure by around 100 residues. This strand is conserved in homologues but the intervening sequence is not. Much of the function of Swiss:P10930 appears to reside in this intervening region. In the tertiary structure of the phage baseplate this domain forms part of the 'collar'. The domain may bind SO4, however the residues accredited with this vary between the PDB file and the Swiss-Prot entry. The long unconserved region maybe due to domain swapping in and out of a loop or reflective of rapid evolution. 	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.77	0.72	-4.18	181	1934	2009-01-15 18:05:59	2003-11-03 17:20:07	7	82	865	5	447	1768	405	51.40	41	13.56	CHANGED	GpIhhauhs......hs........P.........pG.....WhhCsGphlshsp...ssLau...llGshaG.Gs..GtsoFsLPDLRGchs	..........................GsslsaP.us......ss.........P...................................sG............ahhssGp...sa.st.sp...YPpLhs........................................u.........hso.......h..sLPDhRGhh......................	0	134	266	347
+7313	PF07485	DUF1529	DUF1259; 	Domain of Unknown Function (DUF1259)	Yeats C	anon	Yeats C	Family	This family is the lppY/lpqO homologue family.	25.00	25.00	27.20	27.10	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.50	0.71	-4.38	43	461	2009-01-15 18:05:59	2003-11-04 10:36:12	6	3	198	0	107	299	12	120.00	35	80.42	CHANGED	ss.plsplLGpKGshs..sGVa+lshsRtDlplshpGhslss.s..hulsshhuFps.sss.spAhhhGDhVLlpcEVsPVhpsLppsGIpVTAlHNHhLt-pP+lhahHhtuhscsscLApsl+sALcth	...........ttlsphLG.ppGphs..sulh+hslsRpDhplphpGhplss..s..hulsohhuFps...sss.GcAhlhGDhVlhpcElssVhpulpstGIploAlHNHhLp-pPplaahHhtuhs.DsssLA+sl+sAL-t.......	0	45	78	91
+7314	PF07486	Hydrolase_2		Cell Wall Hydrolase	Yeats C	anon	Yeats C	Family	These enzymes have been implicated in cell wall hydrolysis, most extensively in Bacillus subtilis. For instance Swiss:P50739 is expressed during sporulation as an inactive form and then deposited on the cell outer cortex. During germination the the enzyme is activated and hydrolyses the cortex([1]). A similar role is carried out by the partially redundant Swiss:P42249 ([2]). It is not clear  whether these enzymes are amidases or peptidases.	21.70	21.70	21.70	21.90	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.71	0.72	-3.53	170	1705	2009-01-15 18:05:59	2003-11-05 10:54:44	7	29	750	0	448	1369	387	105.20	32	42.38	CHANGED	cGEshpGplAVAsVllNRV.c......sspFPs..olsuVlaQs.........QFohs.ss.......................Gph.p.h........ssp....puhc...sApps.L..sGt...sssssAhaa..as.sts..s.s.p...Wh...shphsspIGsHhFac	...........tGEshpGplAVusVllNRV..c..........ss.p.FPs.......olssVlaQs.......stFsss.ss..............................................................Gphth..........sp.....pshp....sAccs.l........sGt.................s.....ss.s...........sAlaa..assts......s...s..p...........Wh.....st.hh...tplGpHhFhp..............................................................	0	191	328	375
+7315	PF07487	SopE_GEF		SopE GEF domain	Finn RD, Moxon SJ	anon	Pfam-B_18665 (release 7.8)	Domain	This family represents the C-terminal guanine nucleotide exchange factor (GEF) domain of SopE. Salmonella typhimurium employs a type III secretion system to inject bacterial toxins into the host cell cytosol. These toxins transiently activate Rho family GTP-binding protein-dependent signaling cascades to induce cytoskeletal rearrangements. SopE, can activate Cdc42, an essential component of the host cellular signaling cascade, in a Dbl-like fashion despite its lack of sequence similarity to Dbl-like proteins, the Rho-specific eukaryotic guanine nucleotide exchange factors [1].	19.60	19.60	20.80	22.60	18.70	16.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-10.86	0.71	-4.28	2	188	2009-01-15 18:05:59	2003-11-05 11:19:39	8	3	146	6	6	80	0	160.40	71	70.50	CHANGED	AVLTsKsVKDFMLQpLNslDI+GsASKDPAYApQTpEAILSAVYSpNKDQCCpLLISKGlsIsPFLpEIGEAApNAGLPGphKNsVFTPuGAGANPFlsPLIuSAs.KYP+MFINppQQsSFKhYAEKIlMpEVsPLFNcssMPTPQQFQLhlENIANKYlQNss	........................AVLTsKsVKDFMLQpLNslDI+GNASKDPAYARQTCEAILuAVYSNNKDQCCKLLISKGlSITP.FLKEIGEAAQNAGLPGE.hKNGVFTPGGAGANPFVlPLIAuASlKYP.HMFINH..NQQVSFKAaAEKIlMKEVsPLFNcsoMPTPQQFQLTlENIANKYLQNAS............................................................	0	3	3	4
+7316	PF07488	Glyco_hydro_67M		Glycosyl hydrolase family 67 middle domain	Finn RD, Moxon SJ	anon	CAZY	Domain	Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans.  This family represents the central catalytic domain of alpha-glucuronidase [1].	20.30	20.30	21.30	21.30	17.90	19.60	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.83	0.70	-5.54	37	290	2010-01-08 16:36:33	2003-11-10 10:33:56	7	7	257	17	125	302	12	316.00	52	44.22	CHANGED	L+hltput....slssls.........hhpsPpstlRhlNcW....DNlD......GolERGYAGtSIFahs...................shsths.sRhtpYARhLASlGINulVlNNVNAps......plLospalpcluplADlFRPYGI+laLSlNFASPhp....lGG...LsTuDPLD.cVhsWWpppsscIY.phIPDFGGFLVKAsSEGQPGPhs.YGRTHA-GANMLAcALpPaGGlVhWRAFVYsp...p.p.-hpsDRA+uAY-pFpPLDGpFcDNVllQIKNGPIDFQVREPsSPLFGuh.+TshhlEhQITQEYLGQpsHLsYLsPhWc...ElLcaDsascGcs.SpVtcllsG..ph....aspphuGhAGVuNlGsDpNW	..................t.ttshppls.htpsPphtlRhlNHW....DN.hD......GolERGYAG...t..S..lahhs....................sh....th...sRhpcYARh.ASlGINusV...lNNVNups................phLospaLp.clu.tlA-lFRPYGI+laLSlNFuuPhp...............l....GG........L..sTuDPLD.pVtpWWcppsccIY.ph.IPDFGGFLVKA.sSEGQ..PGPhs.YG..RoHADGANMLAcAL....tP..a.G...GlVhWRAFVYs.......p-p...............psDRA+tAYccFpPLD.........GpFcDNVllQlKNGPlDFQsREPhSPLF.Guh.+TshhlEhQITQEYLGQppHLsYLuPhW+.EhLcaDTh.s..cG......c......s......S.....pVtc.llsGph..........hs....p.t.....hs..GhAuVuNlGsDtsW......................	0	42	84	108
+7317	PF07489	Tir_receptor_C		Translocated intimin receptor (Tir) C-terminus	Moxon SJ	anon	PRINTS	Domain	Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation [1]. This family represents the Tir C-terminal domain  which has been reported to bind uninfected host cells and beta-1 integrins although the role of intimin binding to integrins is unclear. This intimin C-terminal domain has also been shown to be sufficient for Tir recognition [2].	20.50	20.50	21.00	97.30	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.38	0.70	-4.59	6	133	2009-01-15 18:05:59	2003-11-11 10:58:32	6	2	104	5	1	76	1	210.30	70	40.11	CHANGED	lESNAQAQpRYD-QpAKRQpELslSSGsGYGLSGALILGGGIGAGVTAALHRRNQPsEQpTTTTTpTs......................lpNpsusNTsAQG...NsDToGsE-.outoRRsSpuSsAS.phSDTSSs-TV.NPYA-VshopNssph..ctsEEsIYDEVAAD.PsYSsIQ+huGssPso.uRLlGsPGpGIQSTYALLA.SGGLRhGMGGLTGGupSAsSosNssPsPGstRFV	.IEsNAQAQpKYDEQpAKRQEELplSSGsGYGLSGALILGGGIGsuVTAALHRKNQPsEQ.TTTTTp.Ts.......................V-NpPuNNTPAQG...NsDTsGuE-.o.tSRRsS.ASsuS.saSDTSShGTVpNPYADVttuhpDS.s..ppSppsl.s.sssD..ssYSsIQH.stsosss.uRLlGsPutGIQSTYAhLA..SGGLRhsMGGLTGGup.SAVsTuN..ssPsPGstRFV.............	0	0	0	1
+7318	PF07490	Tir_receptor_N		Translocated intimin receptor (Tir) N-terminus	Griffiths-Jones SR, Moxon SJ	anon	PRINTS	Family	Intimin and its translocated intimin receptor (Tir) are bacterial proteins that mediate adhesion between mammalian cells and attaching and effacing (A/E) pathogens. A unique and essential feature of A/E bacterial pathogens is the formation of actin-rich pedestals beneath the intimately adherent bacteria and localised destruction of the intestinal brush border. The bacterial outer membrane adhesin, intimin, is necessary for the production of the A/E lesion and diarrhoea. The A/E bacteria translocate their own receptor for intimin, Tir, into the membrane of mammalian cells using the type III secretion system. The translocated Tir triggers additional host signalling events and actin nucleation, which are essential for lesion formation [1]. This family represents the Tir N-terminal domain  which is involved in Tir stability and Tir secretion [2].	25.00	25.00	31.00	31.00	21.70	19.80	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.66	0.70	-4.77	4	135	2009-01-15 18:05:59	2003-11-11 11:08:53	6	3	104	0	1	78	0	256.50	76	48.76	CHANGED	MPIGNLGHNsNVss.IPPAPPLPSQTDG.AtGupGQLIsSoGsLGSRhLFTPlRNSVADusDuRuSDlPGLPsNPhRlAA..SEloLpsGFEVLHD+GsLDTLNptIGSSsFRVETQ-DGoHlAIGQKNGlETSVlLS-QEauSLQuIDPEGKs+FVFTGGRGGAGHuMVTVASDIsEARQRIl-KLEPKsot..........................csopSGusNSuEsp...ssopopTSTSTSSLRSDPKLWLSLGoIAAGLIGhAATGIAQAlALTPEPDDPTTTD	.MPIGNLGHNPNVNs.IPPAPPLPSQTDG.A.GGRGQLINSTGPLGSRhLFTPlRNShADSuD.sRASDlPGLPsNPhRLAA..SEloLpsGFEVLHD+GPLDTLNpQIGSSlFRVETQ-DGpHlAlGQ+NGlETSVVLS-QEaupLQSIDPEGKsKFVFTGGRGGAGHAMVTVASDIsEARQRIL-hLEPKsTGtppsts....................c-opSGu.sosps.....hoETpTSTSTSSLRSDPKLWLuLGTlAsGLIGLAATGIsQALALTPEPDsPTTTD....	0	0	0	1
+7319	PF07491	PPI_Ypi1		Protein phosphatase inhibitor  	Wood V, Studholme DJ	anon	Pfam-B_11090 (release 10.0)	Family	These proteins include Ypi1,  (Swiss:P43587), a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor [1] and ppp1r11/hcgv (Swiss:O60927), annotated as having protein phosphatase inhibitor activity [2-3].	19.50	19.50	19.60	25.50	18.50	18.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.15	0.72	-4.34	38	331	2009-01-15 18:05:59	2003-11-11 14:35:32	6	8	258	0	231	305	1	66.50	40	41.30	CHANGED	lL+LRssp............................ppc++VpWsEsVVDNEphsKKKSKlCCIaHts.+sasE...........SSo-......ssuss.-	...............................................pLp......................................psc++VpWspssVD.NEths+KpSK.....s.........C...CI.Y+Ks.+sas..E....................SS.o.-s.ss-p.pp................................	0	78	125	191
+7320	PF07492	Trehalase_Ca-bi		Neutral trehalase Ca2+ binding domain	Finn RD, Bateman A, Wood V, Studholme DJ, Moxon SJ	anon	Prosite	Domain	Neutral trehalases mobilise trehalose accumulated by fungal cells as a protective and storage carbohydrate. This family represents a calcium-binding domain similar to EF hand. Residues 97 and 108 in Swiss:O42893 have been implicated in this interaction. It is thought that this domain may provide a general mechanism for regulating neutral trehalase activity in yeasts and filamentous fungi [1].	25.00	25.00	25.90	25.00	24.30	16.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.36	0.72	-4.62	19	181	2010-01-08 16:37:03	2003-11-11 16:42:46	6	3	147	0	122	182	1	30.00	62	4.12	CHANGED	LcpLLppEDTDpNhQITIEDpGPKVlsLGT	..LcpLLppEDTDpNhQITIEDsGPKVlslGT....	0	37	70	105
+7322	PF07494	Reg_prop		Two component regulator propeller	Yeats C	anon	Yeats C	Repeat	A large group of two component regulator proteins appear to have the same N-terminal structure of  14 tandem repeats. These repeats show homology to Pfam:PF01011 and Pfam:PF00400 indicating that they are likely to form a beta-propeller. This family has been built with artificially high cut-offs in order to avoid overlaps with other beta-propeller  families. The fourteen repeats are likely to form two propellers; it is not clear if these structures are likely to recruit other proteins or interact with DNA.	20.40	15.10	20.40	15.10	20.30	15.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-7.26	0.75	-7.61	0.75	-3.21	668	7311	2012-10-05 17:30:42	2003-11-17 13:40:01	6	214	468	96	1696	7326	915	23.90	33	6.00	CHANGED	slsss.tlh..slhp...DppG.plWluops	..............Lsss.plp...slhp...DppG.plWlGTt.....	1	834	1511	1628
+7323	PF07495	Y_Y_Y		Y_Y_Y domain	Yeats C, Bateman A	anon	Yeats C	Domain	This domain is mostly found at the end of the beta propellers (Pfam:PF07494) in a family of two component regulators. However they are also found tandemly repeated in Swiss:Q891H4 without other signal conduction domains being present. It's named after the conserved tyrosines found in the alignment. The exact function is not known.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.15	0.72	-4.22	79	2976	2012-10-03 16:25:20	2003-11-17 14:52:01	8	220	527	18	642	2956	292	64.40	23	6.25	CHANGED	shssspphpYpYhlpuh-.spWhphss.s...........phsassLssGpYplplpspsptsphs.s..tplslplt	..........................tspphpYpYpLcG..h..-..pp....Whp.h.sstp..............phsaosL..ssG.pYphpV+.up.sps.u.thstp....tplphhl...................	0	299	555	608
+7324	PF07496	zf-CW		CW-type Zinc Finger	Yeats C	anon	[1]	Domain	This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by [1], and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including ...chromatin methylation status and early embryonic development." Weak homology to Pfam:PF00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found [1].	23.20	23.20	23.50	23.60	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.38	0.72	-4.26	52	682	2009-01-15 18:05:59	2003-11-20 14:53:00	10	54	121	3	435	667	21	48.90	35	6.09	CHANGED	thWVQC-..pChKWRpLP..tphs...pplsc..tWhCphNs.....ssth...ssCsssE-ht	........hWVQC-..pCh.KWRpLP....tphs......pphsc..pWhCshNs.....ssph......spCss.PE-...................	0	120	218	310
+7325	PF07497	Rho_RNA_bind		Rho termination factor, RNA-binding domain	Finn, RD	anon	Pfam-B_1610 (release 11.0)	Domain	The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers [1].	21.00	21.00	21.10	21.40	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.42	0.72	-4.34	16	3771	2012-10-03 20:18:03	2003-11-21 13:57:14	7	13	3677	47	859	2307	2356	77.10	55	16.60	CHANGED	lau-GlLE.lLsDGFGFLRSs-ssYLsGsDDIYVSPSQIRRFsLRTGDolpGpIRsPKEuERYFALl+V-slNh-sPEp	..................hscGlLE..IL...........D.....G.aGFLRosp.sYLsGs.-DIYVSsSQI.RRFsLRTGDslsGplR.........s.......P..............K.-........G.............E..............R............Y...........FALL+Vsp..VNhcsPE...............................	0	304	582	738
+7326	PF07498	Rho_N		Rho termination factor, N-terminal domain	Finn, RD	anon	Pfam-B_1610 (release 11.0)	Family	The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts.  It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers [1]. This domain is found to the N-terminus of the RNA binding domain (Pfam:PF07497).	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.76	0.72	-4.19	139	3972	2012-10-03 03:04:30	2003-11-21 14:02:28	7	30	3568	44	1023	2585	1952	41.90	35	9.71	CHANGED	-L.cphsls-LhplAc.clsl.c....shuphRKp-LIFsILcspucpss	........pL.cshslsELhplAc.ph.sl.c.....s.huc.....h+.Kp-LlaAIl+tpscps............	0	349	705	889
+7327	PF07499	RuvA_C		RuvA, C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_1373 (release 11.0)	Domain	Homologous recombination is a crucial process  in all living organisms.  In bacteria, this process the RuvA, RuvB, and RuvC proteins are involved. More specifically the proteins process the Holliday junction DNA. RuvA is comprised of three distinct domains. The domain represents the C-terminal domain and plays a significant role in the ATP-dependent branch migration of the hetero-duplex  through direct contact with RuvB [1]. Within the Holliday junction, the C-terminal domain  makes no interaction with DNA [1].	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.28	0.72	-3.79	100	4234	2012-10-01 23:03:33	2003-11-21 15:47:17	8	7	4202	23	886	2640	702	46.70	32	23.40	CHANGED	shhs-ulpALhuLGYppp-Apcslppl.....ssshs....s-p.hI+tAL+hlt	...............pEAlpALluLGYptpEup+....slpplt........tssto.............s-p..hI+pAL+th.h...............	0	290	583	752
+7328	PF07500	TFIIS_M		Transcription factor S-II (TFIIS), central domain	Finn RD	anon	Pfam-B_1373 (release 11.0)	Domain	Transcription elongation by RNA polymerase II is regulated by  the general elongation factor TFIIS. This factor stimulates  RNA polymerase II to transcribe through regions of DNA that  promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III.  The two C-terminal  domains (II and III), this domain and Pfam:PF01096  are required for transcription activity [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.45	0.71	-4.02	84	1033	2009-01-15 18:05:59	2003-11-21 17:01:31	9	29	337	6	638	962	110	113.30	28	17.99	CHANGED	pscplRspsh.chLhsuLttt..tpp.................ssppstplAtplEp.............................tlaphh....ts...ss...pcY+p+hRSlhhNLKc.+NssL+p+llsGplospp...........LspMospEhAS-ch+ptc.cphpccslppsph	.............................................................................................................pthRppsh.chLhtsLhtt.......pt...t...........................................tppstp.lAtpIEp.......................................................................................................t.lap.h................ps....ss..................tcY+s+hRSlhhNL.KD.+Ns..sL+cpVL...sGp..loPpp...........ls.pMos.-EhAScEl..pphc.cphpccslpph..............................	0	179	295	458
+7329	PF07501	G5		G5 domain	Bateman A	anon	Bateman A	Domain	This domain is found in a wide range of extracellular proteins. It is found tandemly repeated in up to 8 copies.  It is found in the N-terminus of peptidases belonging to the M26 family which cleave human IgA.  The domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function.	20.90	20.90	20.90	20.90	20.10	20.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.40	0.72	-4.03	140	4313	2009-01-15 18:05:59	2003-11-21 17:13:06	7	239	1219	7	576	3447	28	77.50	25	10.80	CHANGED	clpppppsppcp..lsapsppppDssL.pGp.pcVhppGpsGh+phshplshp..sGpcls+p.llspplhp.tPhscllthGTcp	......................................h....p.psp.pcp..ls.F.ps.pppcsssL....t......G......p...pp......V....hp.......p.......GpsGp..+p..h..h..hplhh.....sG..p...c..........s....p.....cp.h.......l..sp.p.l....sp...ts.hsclVclGTc....................................	0	260	400	487
+7330	PF07502	MANEC	MANSC; 	MANEC domain	Mitter R, Fitzgerald S, Guo J, Studholme DJ	anon	Guo J	Domain	This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins [1].  Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors [1].	23.90	23.90	24.20	25.00	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.67	0.72	-3.99	14	245	2009-01-15 18:05:59	2003-11-25 16:33:57	9	11	78	0	128	211	0	89.60	31	20.16	CHANGED	ssspsChsp.....Fps.htshlIcoptSlstGApFLcus.pVtohc-ClpACCossp......CslAlh-tptsss.ss......CaLFsCh..sp.sCpFssppGasoY	..................s..t.C.tt..........h.shllcsptSlp...t.GApaLps...plpstccClpuCCppps......CNlAlh-tptsts.tss..............CaLhpCh....p...p.sCpFssppGahsY.....................	0	24	32	69
+7331	PF07503	zf-HYPF		HypF finger	Yeats C	anon	Yeats C	Domain	The HypF family of proteins are involved in the maturation and  regulation of hydrogenase ([1]). In the N-terminus they appear to have two Zinc finger domains, as modelled by this family.	23.00	23.00	23.10	23.10	21.80	22.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.76	0.72	-4.53	185	2924	2009-01-15 18:05:59	2003-12-02 16:07:56	7	13	1412	12	778	2421	117	34.90	45	9.25	CHANGED	hCspCtc.Eap-Pt..s.RRa+tphhuCspCGP+hslhp	...hCssChp.EhpDPt..c.RRa+h..lsCscCGP+hpll.......	0	258	529	666
+7332	PF07504	FTP		Fungalysin/Thermolysin Propeptide Motif	Bateman A, Yeats C, Rawlings N	anon	Yeats C	Motif	This motif is found in both the bacterial M4 peptidase propeptide and the fungal M36 propeptide. Its exact function is not clear, but it is likely to either  inhibit the peptidase, so as to prevent its premature activation, or has a chaperone activity. Both of these roles have been ascribed to the M4 and M36 propeptides ([1], [2]).	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.11	0.72	-4.49	142	1811	2009-01-15 18:05:59	2003-12-03 12:00:01	8	74	862	2	304	1431	39	50.00	25	8.45	CHANGED	shph..hcspps.spGt.s+sRapQpapGls.VhGspls.lphspsGplpshsGshh	................tapl.hptpps.tpGh.s+l+hppshpGls.Vhuspls.l+.....hs.csGplhtlsGsh.t.....................	1	102	178	249
+7333	PF07505	Gp37_Gp68		Phage protein Gp37/Gp68	Studholme D	anon	Manual	Family	Homologues of phage proteins Gp37 and Gp68 are found in several bacteria.	24.10	24.10	24.40	25.40	23.10	24.00	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.95	0.70	-5.22	10	525	2009-01-15 18:05:59	2003-12-03 20:35:13	6	5	427	0	163	511	57	235.60	33	93.07	CHANGED	scTsIEWTDATWNPlsGCTKl...SPGCsNCYApphAcRhcuhuscpYp.suscppt.hu.hpt.lplctcpLphPtsWc+PRRlFVNSMSDLFHsc..VP--aIpcVFsVMcpsPpHsaQlLTKRssRhtclhsphth..............................sNVWLGsSlEsps.u.hRI-cLRcVPAulRF....lShEPLLGsls.......................................sssLssIHWlIVGGESGssARP.McP-WVRcIR-pCpsuGlPFFFKQWG......................................sh..t.hctuKKAsGRpL-GR...saDEhP	............................................t.................sWNPhtGCp.......+l.......SsGC.....ppCYA...ph.sp.+hth........t....t....t.at.ts..........................................h.........p....h........p..pp...................h...p......h..php.................psphlas.suh.S.......DlF..ttc......hss.pahpcla...p.hhc.....pssp.hpa.lLTKRspRhtphhsp......h................................................................sNlWhGsoVE.spp...s.hR........lsh...L.p.p..lP....A....t..h.+....a........lShEPLLssl.s....................................................................t.h.sh.ss.I.-WVlsGGE....S....Gsp...u...Rs.....h..c.....-..Wlhsl+-QCtt.s......slsFaFKQhG....................................................................................................t...t.................................................................................	0	54	118	148
+7334	PF07506	RepB	ParB; 	RepB plasmid partitioning protein	Studholme D	anon	Blast	Family	This family includes proteins with sequence similarity to the RepB partitioning protein of the large Ti (tumour-inducing) plasmids of Agrobacterium tumefaciens[1-2].	30.00	30.00	30.60	30.70	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.97	0.71	-4.42	15	449	2009-09-10 17:01:13	2003-12-03 20:37:47	6	4	222	0	133	437	33	167.50	21	53.66	CHANGED	ARssLohI-ctthhs+LhppGhscspItsALuhstspltph....cslsptlp.t..thltth.h.lsshuhsppluRsR.lElucLh.........hsh..p.hpss.hhcph.sss+hstLhphl..+sp+tcphospshu..p....tsc.hs.ths...pulpshhcppG.ptpLtlcsspuh........phs+aLscphschhspF	..............................RpcLSaIEcshas......tcLpppGa......s..c..ctIt..sALul.ctstl.sc..h........pslsptl..............ltsIGsAhplG..Rs..RWh..-..lschl....................hsh...p.h.pss....h.....p..uh.........ss..p+hptlhphl.......p.tpt..p..p.ss.p.t.hu..t.......tpp..ht..s.p....tth.hhh.pptu..p.pltltttps..............th.hp.al.tp...............................................................................	0	18	64	92
+7335	PF07507	WavE		WavE lipopolysaccharide synthesis	Studholme D	anon	Manual	Family	These proteins are encoded by putative wav gene  clusters, which are responsible for the synthesis of the core oligosaccharide (OS) region of  Vibrio cholerae lipopolysaccharide [1]. 	20.10	20.10	21.30	26.80	19.60	18.60	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.91	0.70	-5.54	9	166	2009-01-15 18:05:59	2003-12-03 20:40:37	6	2	116	0	15	97	30	294.30	36	92.33	CHANGED	IoVVlQGPV.s..sR.ppptuITppClsSlRsHLPGupIIlSTW.spsluGL-hDpllhs-DPGuslh.a..Dstsp.phN.NRQlVSThsGL+pVpTPYAlKLRuDNhLTustFlslhcpasp..RsspaphFcp+llsossahRc.p+GhsVhFHhSDhFpFGhTpDLLtlW-.sLhp-.phspss.....htp....tshsshphssEQhh...Wlpsh++hs.phcLtphp.-huhpphph.-phhusNlllssPcplGLslsp+Fhtpsphspp......apph-..............WlpLYpphC..s...ht.tsthphhhshhh.....+.+hl+hhhp+lcph	......................IThVlQGPl...........ssITppslpplRphFPtupIIl.....STWcG.......p...s..h.p.sl-......h..D.pll...cD..PGus.hhh......Y......cspsh...lNhNRQlhSThtG...L+tV.K...T....YAsKLRsDNlLssc....p....h....lElaEp.ast......Rtps.a.phL.s........pRllsSshFhhs.c..h.G.hsV.FahSDhFpFGhspDLLplWs....s.chhs.-hc..F.p.p................tY.....scp.....s..sE.Qhl...Whssh...Ls.thclcscp.Dasuhttsh..pFhtNNLlhsss-plGLD...lsc...R.h..hc...psshsh-.............ashpc...................WhhL.p.p.l............hhhhh.........t.ptlt.hh+phh.h.........................................................................................................................	1	8	10	13
+7336	PF07508	Recombinase		Recombinase	Studholme D	anon	Domain	Family	This domain is usually found associated with Pfam:PF00239 in putative integrases/recombinases of mobile genetic elements of diverse bacteria and phages.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.08	0.72	-3.80	73	4989	2009-01-15 18:05:59	2003-12-03 20:46:19	8	48	1838	0	981	4422	747	105.20	23	21.67	CHANGED	sccutll+p.lachh.......h..puhuhpplsphLsppsl....s.pstt..........................W...stssl.......pplLpNshY..h............................Ghhhhsppt.......................t.hhhhps...........ta.slloc-haptspphhppp	..........................................cpAtlV+tIFchh................h.....pG......h....u.....hppIuct.L.s.p..c..ul...........s...pstt..........................................W......stssl.........ppILpN...h.Y.h...............................................................Gph...h..ht+pp..........................t...........p..p..h.h.h..c.s..................tH..p..sII.s.p-happsQphht...........................................................................................	1	429	755	881
+7337	PF07509	DUF1523		Protein of unknown function (DUF1523)	Studholme D	anon	Manual	Family	\N	22.30	22.30	22.70	24.50	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.24	0.71	-5.04	20	220	2009-01-15 18:05:59	2003-12-03 20:50:56	6	1	218	0	38	192	35	165.30	42	92.02	CHANGED	M+h.lK...hsllhlhalllhuhlaYsLPpaDlsRIoGsEVKRh..sc.sslhhusPssG......ssRDVaFIpT..........hc.....sst+shVYRNEDTsWuaP.YFKFsSAsLQAcApsh..sps.sphVtIcaYGWRlshhohFPNAlSI+sVsss-s.tshPahshllaslLhhhhahshphhRpah	......................................hhh....h+...hhllhshalhlhhhlpYshPcY-lshlTGsEVKRh..scssslstssPssG.......ssRDVYF.IpT...........pc.....cst+lhVYRNEDTtWGaPaYFKFsSAslQAcAQuh......s..s..sphVpl+YYGWRIshhs.FPNslsl+slsps-s..shPlFuaIhaslLhhhhahshphlRth................	0	5	19	30
+7338	PF07510	DUF1524		Protein of unknown function (DUF1524)	Studholme D, Bateman A	anon	COGs (COG3472) & PSI2 target BIG_246	Domain	This family of uncharacterised proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.14	0.71	-4.33	240	2469	2012-10-05 18:28:12	2003-12-03 20:53:01	6	22	1617	0	608	2165	312	139.90	16	30.04	CHANGED	hspspphtpphtthshhstttt...thhhllt.php.p.h.......stt............................l-HlhPps.st.p...........................tht.t...ttppthhss.l...uNLshls.tphN....sphu...s......psa...........htKpp......ta.t.....................................pphhhsp..lt....................hppp...ash..phlppRpptLhch	......................................................................................................................h.t.t........h..hllh.....php...p.h..........pht.....ph.................................I-HlhPps.sh..pt................................................................tht.t..ttpp+pphhss..l...uN...Lhhls..tptN............uphu...s..................tsa.........................h.cpp..........ta.t............................................pshh.hsp...lt...................................ppp....a.s...t..hp...tcppthh..h................................................................................	0	200	420	542
+7339	PF07511	DUF1525		Protein of unknown function (DUF1525)	Studholme D	anon	Manual	Family	\N	21.60	21.60	21.60	21.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.52	0.71	-4.09	32	218	2012-10-03 14:45:55	2003-12-03 20:54:55	6	1	164	0	63	210	8	108.30	39	79.60	CHANGED	tAs.....hhVhT-sp+Plp.......sssss..pVhhLDtsc+lptpLuspLPucPppAtt.spph..........lpuss.pphppplspAapGlscAWphGlpKlPAVVhD....pchVVYGpsDVspAlthhpta+pp	.....................................................................t.AtshlhTDppH.Plp.......ssssspll.LDtspplcspLsstLP..u.sPppAtt.hspph..........lpSsshpphQpcL...s...pAYQulscAW.u.lGlpKlPAVVhD....ccaVVYGpsDVspAhthhtthpt.t..............	0	8	30	51
+7342	PF07514	TraI_2		Putative helicase	Studholme D	anon	Manual	Family	Some members of this family have been annotated as helicases.	23.90	23.90	24.00	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.78	0.70	-5.67	21	472	2012-10-01 20:28:14	2003-12-03 21:24:15	6	5	346	0	109	489	32	271.90	31	46.79	CHANGED	Gahss.su.pLLuo.hcpcLlpplhppsuhscpp.......Fcphahtslc+YAchVQhLPASEsHHHutsGGhLcHuLElshaul+lppualLPssusPEcputppcuWpsAshhuALlHDlGK.lsDlclphp.....cGs.pWtsatusLsp.h+h+....Yh.......+sR.thphHsshuuhlhspllspssLsWLup.hPc.lhssLlhsluG..ph-c...........ussLuElVppADptSlspsL.u.ussstuhtssspslp+pLlsAlRtLltpchcls.spssucsW...lsp-.uLaLVtKssuDplpuhLhspGls.ulPss..sssLh-hLtspGllpsss.-...scul	................................................Gh..s.ss.pLLus..ppphlpplhp.p.....s.u.hs.pp........Fpphhh.sl..c..c..hAthlQ.l..PASEsHHHutsGGhlcHuLElshaAh+lppuh.l.hss....su....sPE-pstppttWpsAshhuAL...hHDlGK.lsDlplp.t......sGp...tWtP.h.h.ss....lsp....h+h+....Yh........ptc......HtthusllhppllstpslsWLup.hPp.lhtsLlhsl....uG.....phpt.............sslLuclVhpADptSlsppL.t.tp.sht.........t...........t...sh.c.lhtuh+.ll.tp..ph...s..p..ucsa..............h.pp....tlal..h.p.hsc.lhthl.t.p.....th..........hPtp..s..hhs.h.p.thh..s..............................................................	0	14	49	84
+7343	PF07515	DUF1528		Protein of unknown function (DUF1528)	Studholme D	anon	Manual	Family	\N	21.50	21.50	22.70	21.50	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.41	0.72	-4.00	40	328	2009-01-15 18:05:59	2003-12-03 21:28:01	6	4	247	2	80	310	7	98.90	36	19.65	CHANGED	lhlN-scAhVHhVssssFLVoPulFpcYhpcp............uptp..ptpsaphlQ+pFE+LplH++p........sGhNlWpCcVhGsRKs.p....cLpGYLlpssph..hhsp.s.PssNPaLpl	..........lhlNcscAhlHhVssssaLVoPulFppYhppp............uttp..s.psaphlQ+pFEcL..plH++p........sGhNlapsplhGsc+s.p.............pLpGYLlpssph...hhsp.h..P.sNshLp...............................	0	9	37	59
+7344	PF07516	SecA_SW		SecA Wing and Scaffold domain	Finn RD, Bateman A	anon	Finn RD	Family	SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane.  SecA protein achieves this translocation, in association with SecY protein, in an ATP  dependent manner.  This family is composed of two C-terminal alpha helical subdomains: the wing and scaffold subdomains [1].	26.70	26.70	28.30	26.90	26.20	26.50	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.57	0.70	-4.57	171	5380	2009-01-15 18:05:59	2003-12-04 14:10:21	8	25	4467	32	1115	3923	3227	206.70	32	24.32	CHANGED	sIcp.....phlo+ulEpAQKKVEupNF-hRKpLL-YDDVhNcQRclIYppRpclLpu...........................c..c..lpchlh.phhccslpph.....lppah....stp..........ppas...hpsLpptlpphh.s.h..phslsph..............pths............................................tcp..lpcplhcthpptY............p...p.Kppphs..................................................t..chhcplE+hlhLpslDppWp-HLpsMDpLRpuIsLRuYuQ+DPlhEYKcEuaphFppMlpslcpcslphlh...+lpl	................................................................................................................................sIEpphlo+ulEsAQ++VEupNF-hRKplLcYDDVhNc...QRclIYppRpc.l.Lc..s..........................................................................................................................c..c..lpp.p.lt.shhccslpph.lsta.h.s.sp...........cpac..........lps.L.h.p.hlppth..s..h.....chsl.p..ph....................pth.s.......................................................................................................................................t-p....lp-tlhpps.ctY.....pp....+pp.t.ls........................................................................................................................................t..-hh.c.phE..+h..l..hLpslDstWp-HLssMDpLRpuI.tLRuYu....Q+sPl.EY+pEuaphFppMlpslcp-ssphlh+sp.h...............................................................................................................................................	0	382	745	956
+7345	PF07517	SecA_DEAD		SecA DEAD-like domain	Finn RD	anon	Manual	Domain	SecA protein binds to the plasma membrane where it interacts with proOmpA to support translocation of proOmpA through the membrane. SecA protein achieves this translocation, in association with SecY protein, in an ATP dependent manner [1,2].  This domain represents the N-terminal ATP-dependent helicase domain, which is related to the Pfam:PF00270 [3].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null --hand HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.72	0.70	-5.10	90	5907	2012-10-05 12:31:09	2003-12-04 16:33:08	9	48	4809	34	1211	5542	4671	373.00	47	44.91	CHANGED	l.pphh....tsts....c+pl++h..............pp.hlppIsshcsphpsLoDc-Lcpcopch+p+l.......ppG......................................c.......oL-p..............................lLsE...AFAllREAupR..............................................slGhctaDVQllGGlsL.........+pGpIAEMpTGEGKTLsAoLPuYLNALsG+GVHlVTVNDYLAcRDu-.hMu.lacaLGLoV..Gllhsshs..................................................s.ppR+p...............................................................uYtsD..ITYuTNsEhGF....DYLRD.Nhshstppt.....................Vp.R...shpaAIVDElDSlLIDEARTPLIISGssppssphahthsphstphppppptphppppptthhpppsttptcphhthtthhtt.........................................................................................................................................................tphphhchlppuL+AptLac+cpcYlVp-scVhIVDEaTGRlMtGRRao-GLHQAIEAKEsVpIpsEspTlAoITaQNaFRhYpK.LuGMTGT..ApTEspEFt	..............................................................................................................................................................h....h..s.ts.c+pl+c.h..............pc.hlp.pls....sh.E.sphpt.L.........oD..-p....L+s...KTtE...F+pRl..........tp.G............................................................................-........oL.D.s...................................lL.PE...AFA..l.V.R...EA..u.+R...........................................................................Vl..G..h..c..aD.VQl.h.G...G.h..lL...........................Hp.G.p..IAEM......+......TGEGKTLsA.T.hPs..Y...L.N..A.L..........s..............G.....+.......G..V.H.....VV.T.V.NDYLA.pRDu..-........Mu.la.p.F..LG..L..o.....V..G..l.......l....s..s.h.s...................................................s..tp.++..p...............................................................AY......s......s......D....ITYuTNN....................EhGF.....D.Y.LRD..NM.sh.p...h...--h.....................................V.Q...R...s.....hp.....a..AIVDE.......VD.SI..L.....IDE.ART.PL..IISGssccsophYhphsphh.pLhppcc.p.cppppthhhsppshpptpphhthtthhtt..........................................................................................................................................................tsh.lh+alstAL+Achlhp+Dh-YlVp-uEVlIVD-aTGRhMtGRRaS-GLHQAlEAKEGVpIpsEsp.Th.A.o...ITa.QNaFRh...Yc..........K....LuGMTGT..AcTEttEF......................................................................................................................................................................................................................................................	0	452	817	1053
+7347	PF07519	Tannase		Tannase and feruloyl esterase	Studholme D	anon	Manual	Family	This family includes fungal tannase [1] and feruloyl esterase [2-3]. It also includes several bacterial homologues of unknown function.	20.00	20.00	20.10	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	474	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.63	0.70	-5.78	8	801	2012-10-03 11:45:05	2003-12-04 17:38:35	6	15	346	0	504	870	96	395.40	25	79.35	CHANGED	CcVpG.....hpsscspt.pItFplpLPs.sWNGRalQsGsGGasGslsssst.s......hs.sLspG.aATsuTDuGHcAsss......sssFu.hss-shhsFAYpAl+cssssuKtLlpsaYs+sscp...sYFhGsSsGGREGLhAAQRaP--YDGIlAuuPuhsa.lptp...hatuh.u+sshss.....sshlsssclpllspAslspCDslDGssDGlVsDPctC+hshs......psLhCpush.........ssc....................sCLTssQlpslsplas.Ghp.....usGpshYsGas..s.....hGs.ssshspWhhss...............ts.hsstssphhp.hl..............hpssNaDsso.hch...tthccp....htplsssIsATsPDLosFRs+GGKLIhapGhsDPsloPtuolpYa-uVhA+hsts............pscsFhRhahlPGhsHsGuGsusssh...............DhLsshssWVEsGpAPspllAsctssss.........................hsRoR.LCpYPphshacGpGsscsAsSapCs	.................................................................hts....tt..t....tlthph..hL.Pt...s............Ws...s...R...hh.h...Gs.GGh.s...u...sh...s.s...................................hs.s.lt..G..aAshuoDsGa......s...us............................h....u......hs..p......t......h.h......sa.u.apulpths.huK.tlhpthY..u..p.s......s.p.h...................oYa.GCSsGGR..puhh...tsp+aPppaDGllAusPu...hp...h..sp.............hhth..h............h....ht.................s.h.ss.s.p.h.p.h.ltp.ts.lttCD.s.l..DG..h..tD.......Gllps..st...hCp.hp.p............shhC.tss..............ts..............................s.s.lostph.....tshp....p.las....s.hs.........ssGph....ha...sh..............s..................s...........h.t............................................s..th.ht.....hh..........................................s.s.h..s..t.hs...............t.....t...tt.h......h.hs..s...sp...sD.L.osap..p..p....G...GKllhaHG................h.......u.....D.hlsstsohtaappltpt.h..t.t.............................thp..pFhRhahlPGhsHCs....s...u..s..s..ss...h............................................s.hltslhpWVE..p.G..huP.pt.l..usths....sst...........................................thpR.lC.aPhhsh.at......u..G..s...pts...tsa................................................................	0	92	240	394
+7348	PF07520	SrfB		Virulence factor SrfB	Studholme D	anon	Manual	Family	This family includes homologues of  SsrAB is a two-component regulatory system encoded within the Salmonella pathogenicity island SPI-2.  Among the products of genes activated by SsrAB within epithelial and macrophage cells is Swiss:Q9KIJ9 [1]. Homologues are found in several other proteobacteria.	19.10	19.10	19.60	20.60	18.10	19.00	hmmbuild  -o /dev/null HMM SEED	1002	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.76	0.70	-13.73	0.70	-7.08	12	283	2009-01-15 18:05:59	2003-12-04 17:59:07	6	2	255	0	53	223	26	878.30	58	97.93	CHANGED	M.LspLscapp.ploLl.cSGIQFLDFuLp.phssc......sucFlcpsusGslhRL..ctsss+a..hlP...............spsGh.sclscs-h.olshcpSLclhpslWLPlPFhRhpPscs......FspGPsNWARlpllpL.spPDpcGNTHRlsLAFDTplhscpts.htYLAPscsDlpsGssFuLAa+sc-lu.FL-..............psWVssWL+ElFpp.s.tp.ctRstc-........lpctLtthEapAHYLNlLslLG...........splplPcl+llssshps....sIsVDLlLDVGNS+TCGlLIE-Hsp-ss.GLppshcLpLRDLSpPchlYs-.FESRlEFApApFG+pcaSlcSGRsDAFhWPoIsRVGsEAsRLAhpRpGTEGuTGlSSP+RYLWD-pshtpGWRF.....stshspoppEPLATAsPltphlN-pGcsLapL...........st--RlPVFpPpYSRSSLMTFMLuElLsQALhQINSsApRh+hspsssPRpLRslILTlPsAMPKsERcIFRpRhppAluLVWKuhGWa.tDsDh...p.tsppp....spsPlPtlphcWDEAoCGQhVYLYsEstspaGG+scpFFssh.t.....RP-p....t..s..t+sLRlASIDIGGGTTDLsIopYtLDcG.....hGsNVpIhPc.hFREGFKVAGDDILLDlIpchVLPAlptuLpptGhss..sculhucLFGs-..ut.stptlLRQQhsLQlFhPlGhulLpsYEsaDPhsspupl.phoFu-LLt..............................phP.oppVlsYlspslc+...susssFslhslPLtlcLspl+pthl...ssphslspslcuLCEllphYsCDVLLLTGRPSRLPGlQALhRphpPlPssRllPlcsY+sssWYPFpcpG..RIDsPKoTAAVGAMLChLu.s.RLssFhF+sschtsYSTlRYlGhLDsN.NtlpDpslaY+DI...........DLDsPshpLs.ctpFphRGphpLGFRQLss-RWsAoPLYpLsls..ssclA+plsG.......cusLpVcLp.......ptus........pcsshEpFtIs-A.h.psGspls...........pplpLpLsThssptusss.YWlDoGSlhhc	........................MLssLsDYKQ..plTLItNSGlQFLDFuLoPp.tss...c.......u+F.............VR..K...oA..N...GP.....LLR..Ls..ac...psG+Y..sLs.....................................stsGutPEl..VKPE..o.sLc.SLclLsslWLPLPFL.RFsPPRT......FlpGPDNWARlQlhpL...spPD.psGNTHRlTLAFDoplhtph.....s...hLAPsENDlhsGspFALAa+s-Elu-FLD..............pTWlDGWLREsFhphA..uphEpRstpt...........IppuLRpFE.YQAHaLNLLsLLG...........pQLslPElKhsopTLpp...PAlsVDLILDVGNoHTCGlLlEDHuDtss...GL+Q....T.hELQlRsLScPpaL....s.LFpSRVEFupA+FGKQpFSVESGR-D.AFlWPSIsRVGcEAptLAhQ.....Rl..G..T....EGSoGI.....SSPRRYLWDEpshhtsWRF.....sphts.p...sp.....cEPLATAhPLhpLhND-GpPLapL............Ph-ERLPVFSPpYSRSoLMTaMLsElLAQALhQINSsApRL+h...sassuPRQLRolILTLPSAMPK.EREIFRpRMhEAlALV..WKuMG...........WHPtD-..DFs.........ospp+tK........ShVPVP.-lQMEW..DEAoCGQlVaLYNEs.spauGRo-u.FFsuh.A.....RPD+p.p..su.ss..G+sLRlASIDIGGGTTDhAIspYpLDD....G............sGsNVKIoP+LLFREG.FKVAGDDlLLDlIQphVL......Pu.......LQsuLp+AGVss..usuLhupLFGss..GRhDsQulLRQQssL...........QlFMPlG+AlLpAaEp.D..DshAt.....l.cAoFG-LLh..............................ppP.TppVhsYIppsIp+.tLPuu.ussFDIhsVPLplphSpLppthL...uspholTpsL+AlCEslShYpCDlLLlTGRPopLPGlQALhRHLQPlPsNRIl.hDtYpsp-....WYPFsppG..RIsNPKSTAAVGAMLC.LALD.L.RLspF.FKAuDh..t..sYSTlRYLGhLDso..ssLp-ENlaY+-I...............DLDpsshs...L..s..sch+F....lRGs.loLGFRQLsNsRWPAoPLYsLSIs...ssELA+plAG...................Du.V..Ls..V+L+................lpsus..................+csuPE..pFhLu-AhL..pDGos.Vsh..........ctLpLKLNTLAsptpu.uoHYWIDSGSVah.c...........................................................................	0	4	17	37
+7349	PF07521	RMMBL		RNA-metabolising metallo-beta-lactamase	Finn RD	anon	Pfam-B_760 (release 11.0)	Motif	The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases.  The fifth motif appears to be specific to function.\	    This entry represents the fifth motif from metallo-beta-lactamases involved in RNA metabolism [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.99	0.72	-4.14	138	6209	2012-10-01 19:09:44	2003-12-05 14:54:50	7	36	3653	52	1894	4689	1569	40.50	33	7.13	CHANGED	chhtlchplpplc.hSuHAcpp-Lhphlpth.ps...cplhlVHGE.p	...........t.........ppl+..sSGHuspp-lphhlsh...l..+P.........+hhhPVHGEh....................	0	666	1222	1605
+7350	PF07522	DRMBL		DNA repair metallo-beta-lactamase	Finn RD	anon	Mannual	Domain	The metallo-beta-lactamase fold contains five sequence motifs. The first four motifs are found in Pfam:PF00753 and are common to all metallo-beta-lactamases.  The fifth motif appears to be specific to function.\	    This entry represents the fifth motif from metallo-beta-lactamases involved in DNA repair [1].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.69	0.72	-4.02	43	592	2012-10-01 19:09:44	2003-12-05 17:30:10	9	30	300	0	406	592	9	106.50	25	15.45	CHANGED	spltshlTs-.tpsplHll.shs......plp....hpsLtsahpthttp......asplluh+PTG..Wshps.htt..s..t.............................................ttphslaslPYSEHSSapELccFVphl+Pp..clIPTVssss	....................................................................thhTss......t..tsplHhh..h..........php.........hppl..phhpt....t...h................hpph..luhpPou......Wshptt.h..t.p...................................................................................ttt.tha..tlPYS-HSSapELppF..lphl+Pp..pllP.sVs...s.........................................	0	126	211	313
+7351	PF07523	Big_3		Bacterial Ig-like domain (group 3)	Bateman A	anon	Bateman A	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.09	0.72	-3.90	40	2232	2012-10-03 16:25:20	2004-01-06 12:05:57	7	198	845	2	141	1725	26	68.80	28	14.33	CHANGED	lps+DSTIYlGDsWsuc.DNFsSAssKsGps........lsas-lpVsG.......sVDospsGsYplTYoasG......sopolsVTV	...........................h..spcsshhhG...-s..a.ssp..ssh.lsApsc.s.Gss.............ls.hsc..lp.VsG...................plDos..K....s...G.p.Y.pl.oYp.aps.............hptshpVpV........................	0	69	91	112
+7352	PF07524	Bromo_TP		Bromodomain associated	Studholme DJ	anon	[1]	Domain	This domain is predicted to bind DNA [1] and is often found associated with Pfam:PF00439 and in transcription factors. It has a histone-like fold.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.42	0.72	-4.25	12	679	2012-10-10 12:36:46	2004-01-06 13:32:37	8	18	266	0	482	767	3	74.20	24	13.90	CHANGED	pchspslhp.hsluplhppsGa-ssppusLEoLothhtpYlpclucphppau.ptssRspss.htDlh.hsLtchul.sVsp	......................................tcplLphuVup.lh.pp...sGF..-ssp.uu.l-sLT-l.hpc..Y....lpplucssppas..-...t......ts..R..s....t.s......s....htDlh...sh.tph.uh.....t.....................................	0	133	242	379
+7353	PF07525	SOCS_box	Clip; SOCS_Clip; 	SOCS box	Studholme DJ	anon	[1]	Domain	The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.11	0.72	-4.09	141	2186	2009-01-15 18:05:59	2004-01-06 13:59:50	11	135	116	6	1208	1938	0	39.00	35	9.64	CHANGED	stoLpcLCRhsIRpp.lsppt........lppLPLPptLcsYLt.ap	..........shoLpcLCRhsIRpt.lstpt...............lspLP.LPspL+pYLp.a..........	0	198	297	634
+7354	PF07526	POX		Associated with HOX	Studholme DJ	anon	[1]	Domain	The function of this domain is unknown [1]. It is often found in plant proteins associated with Pfam:PF00046.	21.60	21.60	21.80	23.30	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.81	0.71	-3.95	39	330	2009-01-15 18:05:59	2004-01-06 14:12:16	6	5	36	0	166	329	0	129.90	38	22.83	CHANGED	phltsS+YL+sAQcLL-Ehss.Vup.....................ht.tptptsttptpssstssssss..sstsssssspt.ssplo...........ss-ptEhQhKKsKLluML-E..................V-+RY+pYpcQMQhVluSFEsVAGhGuApsYTuLAL+shSRHFRCL+....DAIsu	..............................t.hlhsS+aLpsAQcLL-Ehss.Vst.............................................t...tttt..t..st....t..s...sts.s..s.s.tss....ssps.ttss.s..p.s.ssplu.......................................sspttEhQh.KKsKLluML-E.....................................................................V-.+RY+pYhcQMQhVsuSF-s.......V...A......Gh..GuA.tsYTuLAL+shS+HFRCL+DuIs.s...........	0	16	100	135
+7355	PF07527	Hairy_orange		Hairy Orange	Studholme DJ	anon	[1]	Domain	The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split [1,2].  The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute[2].	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.99	0.72	-4.21	79	952	2009-01-15 18:05:59	2004-01-06 14:24:01	8	6	111	2	510	910	1	42.90	31	15.11	CHANGED	spa+uGapcChpEVs+aL.sshpuh........cs...thpp+LlsHLtpshsth	.......tapsGapcChpEVs+aL.ushcuh...................ss.......slps+LlsHLpphhs..h.................	0	101	143	313
+7356	PF07528	DZF		DZF domain	Studholme DJ	anon	[1]	Domain	The function of this domain is unknown [1]. It is often found associated with Pfam:PF00098 or Pfam:PF00035. This domain has been predicted to belong to the nucleotidyltransferase superfamily [2].	20.40	20.40	21.10	21.00	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.52	0.70	-4.96	4	544	2012-10-02 22:47:23	2004-01-06 15:10:16	9	21	114	0	254	492	0	210.30	43	35.06	CHANGED	pVGSFtKGThhpGsssuDlVllLKoLPTp-sl-tLu+KVttsLctuhcs.........Eshph........hEhGhcIosshs+VRhLIshlPpshpKLEP.hHLDpKhh.upLAulRHs+WFpppApc.......ohplLIRlLKDLspRassFpPLssWhl-LLAahuIhNsPuRQshslshAFRRVFplLAuGlFlPsSuGIhDPsE.uphRltsshTL.QpDssChoAQTLlRlhAaG..GY++ILGhcsssos	.....................................................................................RVG.lAKGLll.+.G-.sl-LVl.lspp.hPTt....sLLpplup...pLs.pLtt.hs.c..........................t.....-sh.........hh................t................hph..s......hp..lo.....Ss...h.h..+....c...........h....t.............s......s..p..s....h.t....h..D...P...........p.h.............LDpphCh.sA.L.Aul...RH..A+WFp.s...+Asslp.....Ss.hllIRlLRDLspRh.Ps.Wts...LpsW.slEL.Lsc.......+uls.....os...ppP...hu.su...cA.h.......RRlhEsluoGllL..........s....s....usGlhDPCE........cps..........hcshshhohpQp...............-slT.oAQ...p.hLRlhAFt..ph+KlL.Gh-s.s......................................	0	60	80	160
+7357	PF07529	HSA		HSA	Studholme DJ	anon	[1]	Domain	This domain is predicted to bind DNA [1] and is often found associated with helicases.	20.80	20.80	21.00	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.26	0.72	-4.19	50	836	2009-01-15 18:05:59	2004-01-06 15:46:46	8	46	264	0	522	792	6	70.80	25	4.41	CHANGED	p+htctp...+p+s+actlLpphthhupDFppt++h+.....hstsp+luchltpaapptpppcp+ctc.......tcpchptltp	...........................+htp.p...+p+p+as.h..Lpphh.hupDFppt++.p.......tupspKls+tltpaHtppccc.pc+ppc.........pcp+h+tlh.....................................	0	155	262	412
+7358	PF07530	PRE_C2HC		Associated with zinc fingers	Studholme DJ	anon	[1]	Domain	This function of this domain is unknown [1] and is often found associated with Pfam:PF00096.	22.10	22.10	22.80	22.50	21.40	21.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-8.95	0.72	-4.07	10	61	2009-01-15 18:05:59	2004-01-06 16:12:08	6	8	16	0	30	76	1	64.50	22	11.32	CHANGED	sppIcppLpcpGapsppl+shpps................ss+sPhNMFhVpLssss-..pcc....ILplKpLGph+.VsVERtp++c-s	................................................IhppLpp.Gassh..plhshppt.................pcps....h.shahlcltss.s..pcc.....lhpl+plst.h.VplEt.phpt.............................	0	13	16	28
+7359	PF07531	TAFH		NHR1 homology to TAF	Studholme DJ	anon	[1]	Family	This corresponds to the region NHR1 that is  conserved between the product of the nervy gene in Drosophila and the human mtg8b protein [1], which is hypothesised to be a transcription factor.  	21.30	21.30	21.50	21.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.15	0.72	-4.35	14	474	2009-01-15 18:05:59	2004-01-06 16:26:22	9	11	109	4	227	399	0	92.60	49	15.33	CHANGED	hcslpKC+pFLssLlcLuss...pus-huppVRsLVpsLlsuplpsEEFsp+L.ptLNusPQPaLVPFLKpoLPsLRphh.sspthlpQsth.hh..ssss	.....scplpKhKpF.LoTL.phusc.....SPElucpVRsLVhsLlsuslph.EE...Fps+LpcthN.s..p..............Pall.PFLK............t.s.........LPhLpptLh.csAphhpQsstQh.s...p..........................	1	38	55	123
+7360	PF07532	Big_4		Bacterial Ig-like domain (group 4)	Bateman A	anon	Bateman A	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-9.12	0.72	-4.45	98	1839	2012-10-03 16:25:20	2004-01-06 16:50:15	6	189	521	0	210	1443	6	61.30	29	9.61	CHANGED	hpshshs.st.........h..Gss.........................pLPppVpshh.s-Gos...p.......p...hsVp.W...........s........stphspsGs.aplpGp..lp..Gh	.................................................h.t.hplh..st........................l..ups....P...........................pLPppVssha...scGpp...p........p...hsVs.W...........s........thsspphspsGs.apVpGp.lp.G.............................	0	96	157	179
+7361	PF07533	BRK	TCH; 	BRK domain	Studholme DJ	anon	[1]	Domain	The function of this domain is unknown [1]. It is often found associated with helicases and transcription factors.	20.90	20.90	20.90	21.10	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.94	0.72	-4.49	20	582	2009-01-15 18:05:59	2004-01-06 17:04:04	11	35	89	5	303	552	2	46.10	40	2.68	CHANGED	slss-pRVsVlspcsG+pLsGscAPpt+cLppWLptsPsatls.....Pct	.....p.su-p.V.VlppcsG+h.LsGs-APptppLp.pWLctsPsYtVs.....Pc.............	0	54	76	170
+7362	PF07534	TLD		TLD	Studholme DJ, Eberhardt R	anon	[1]	Domain	This domain is predicted to be an enzyme [1] and is often found associated with Pfam:PF01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-11.13	0.71	-4.19	112	1684	2009-01-15 18:05:59	2004-01-06 17:16:33	11	56	317	1	1140	1627	32	133.50	22	28.56	CHANGED	ll.assp.pcGtuhps..hhpphp.......pp.ushllll.............ps.sc...h.....lFGuasspta......p.t.......ahGs...spo.FlFpl..........psphtsa+h.....ssps.........thahhssp......p.........luh.Gss..................phuLhl-s.shpp.uhs..p.hs.............soas..ss..hs..........tpppFplpslElWuht	.................................................................................lasst.pcGhS.....hps...hhppht.............hp.sssllll........................................cs.pps....t.............lF...Guass.psh..................................p.spp.......ahGs......scsF.l.Fph................................ps.p.h...p.haph............ssts.......................................t.hh.hhss..............pt.................................lshGus...............................................thuLhlcs......sh.p...uhs.p...s...............toat...s...Ls........................................ttpF.l.tlElath........................................................................................	0	519	685	941
+7363	PF07535	zf-DBF		DBF zinc finger	Studholme DJ	anon	[1]	Domain	This domain is predicted to bind metal ions [1] and is often found associated with Pfam:PF00533 and Pfam:PF02178. It was first identified in the Drosophila chiffon gene product [2], and is associated with initiation of DNA replication.	24.80	24.80	24.80	25.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.50	0.72	-4.28	29	271	2009-09-11 05:51:30	2004-01-06 17:34:58	7	7	203	0	185	277	0	47.60	39	6.36	CHANGED	pcpcsGYCENC+hKY-sh-p.................HltSc+HRpFApscpNatslDsLItpLpp	.......cp+sGYCEsCppKa-..-.h-p.................Hl..hSccHRpFAtpspNattlDplltpL............................	0	50	87	141
+7364	PF07536	HWE_HK		HWE histidine kinase	Studholme DJ	anon	[1]	Domain	Two-component systems, consisting of a histidine kinase and a cognate response regulator protein, represent the best-known apparatus for transducing external cues into a physiological response in bacteria.  The HWE domain is found in a subset of two-component system kinases, belonging to the same superfamily as Pfam:PF00512 [1].  The family was defined by [1] the presence of a highly conserved H residue in the kinase domain and a WxE motif in a C-terminal ATPase domain that is related to Pfam:PF02518. These proteins are found in a variety of alpha- and gamma-proteobacteria, with significant enrichment in the rhizobia.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.64	0.72	-3.55	44	1003	2012-10-11 19:05:54	2004-01-07 14:13:07	9	153	270	0	408	2339	212	82.20	32	14.48	CHANGED	ELsHRVKNhLAslQSlspQTh+pssshschhpphpuRLtALupuHsl....LocspWtuusLp-LlptpLpPats......sp+lplsGPs	..ELsHRlKNhLAlVpuls...p..p....T..h....+..p.....s...s.....s....h....c...p....h..t..p..t...h....p...u...R..lpAL.....upu.a.s.l........L.s.c.....s...s.....W.....p.....u.....s.....s.....l....p....p....Llps....plt.sass...t......ssRl.plpGP..............................................	0	81	201	261
+7365	PF07537	CamS		CamS sex pheromone cAM373 precursor	Studholme D, Williams W	anon	Pfam-B_18913 (release 11.0)	Family	This family includes CamS (Swiss:Q8L313), from which Staphylococcus aureus sex pheromone staph-cAM373 is processed.	25.00	25.00	25.40	25.20	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.98	0.70	-5.40	7	766	2009-01-15 18:05:59	2004-01-21 15:50:20	6	2	576	4	74	428	0	278.80	36	84.01	CHANGED	PaKtupuRGlssssl..ssRhDl-EhEsGLhclup-pFss-sahaQ-GQYlDccplppalt+cp............cs......s.GLNPsh..tssshcphp.ppPhYLopILEpDYhscpDssshpLsGlsIGLAMNSV..appcpstsph...ppsIs-pchhppGcchAppllpclRpp-....shcslPIshAIY+Qts+sSlsPGNFlutssVptsssslssWpsIsEK.hlaPS.spsscpttpDssphppFppplpsaFs.N..asulVGcuhYcccphpcLplDIPlpa.GKuElluhTQalsshl.chaPK.h.clplpIpoupp.EAlIhRpss-ccPhV	.................................PactupuRGlh...s.sh...ssphsht.-aEsGLhpluKc.FsTcpYlaQ-GQaLsppTl.pt......a.Ls.K..................c..p...........s.G...LNPs.......sp.....t..s..c.....phs......sPh.YLspIlEQDahsptsspsh..pltGhsIGLAMNSV.YYp.ccp.ssp......pppls....s...pchhtp...G.+phAscllpplRppc....ph.cs.lPIphAlY+Q.usp.s.SlssGpals.uss.pps..ps.plspWcsIsEKshlhP....S....sstsp.....cp....s........sspFppFpsplpsaFs...s.a....otssupspahcpphpplslslshpaaGpsEhhuhTQalsp.s.cahsp.s.phplpIps.ss...p...pAlI.+ptssccs...........................	0	19	41	56
+7366	PF07538	ChW		Clostridial hydrophobic W	Studholme DJ	anon	[1]	Repeat	A novel extracellular macromolecular system has been proposed based on the proteins containing ChW repeats [1]. ChW stands for Clostridial hydrophobic with conserved W (tryptophan). This repeat was originally described in Clostridium acetobutylicum but is also found in other Gram-positive bacteria including Enterococcus faecalis, Streptococcus agalactiae and Streptomyces coelicolor.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.17	0.72	-7.56	0.72	-4.43	194	1324	2009-01-15 18:05:59	2004-01-21 17:12:02	6	86	159	0	292	1109	45	35.70	41	26.52	CHANGED	HVps..hGWp.s.h.spsGphuGTsGpuhRlEAlclpLssp	..............HVQshGW.......p..s...a.sp...sGp....h......u.GTsGpuhRlEAlcIpLss.........	0	235	272	292
+7367	PF07539	DRIM		Down-regulated in metastasis	Wood V, Studholme DJ	anon	Pfam-B_10642 (release 11.0)	Family	These eukaryotic proteins include DRIM  (Down-Regulated In Metastasis) (Swiss:O75691), which is differentially expressed in metastatic and non-metastatic human breast carcinoma cells [1].  It is believed to be involved in processing of non-coding RNA [2].	24.80	24.80	25.80	26.30	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.60	0.71	-4.77	29	267	2009-01-15 18:05:59	2004-01-22 13:23:18	7	4	244	0	207	278	1	140.10	31	5.54	CHANGED	plhuKFpN.Ksla+usclaph.hhpLLsspssclQKhALcslhsa+ss.sls.Y+-NLpNLLDDspF+DElssFh..hssppps................IpspcRstlhPlllRILaG+hpspssusspp.....uR+tuVlphL.sshppp-lt.Flcluhs.l	....................lFupFtNP+slappsclaph.h.h.pLLsps-tplQ+hALcslhs..aKp..s..tl.hs.Y.c.-sLppLl-.....-..p.......pF+-ELspF..hspppt.................................lcs.pHRspLhPlllRlLYG+hhs+suupstt................tsR+tslLphL.ush..pspElthFlplhhts.............................	0	68	111	170
+7368	PF07540	NOC3p		Nucleolar complex-associated protein	Studholme D	anon	Pfam-B_8562 (release 11.0)	Family	Nucleolar complex-associated protein (Noc3p, Swiss:Q07896) is conserved in eukaryotes and has essential roles in replication and rRNA processing in Saccharomyces cerevisiae [1].	20.70	20.70	20.70	20.70	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-10.17	0.72	-3.72	30	305	2009-01-15 18:05:59	2004-01-22 13:51:56	6	4	269	0	214	288	3	96.10	38	13.28	CHANGED	lhctKEcIAclustlhEDPEENltsLccLtchspsp........phslpKLulloLlsVFKDlIPGYRIRPLoEpEtppKVSKEVp+LRsFEpuLlpsYKtY	..................................................l.ptKpcIAplustlhp..-PE..p..s..lt..........t..........L....+c.Ltphsppp....................................shslpKL...ullolhsVFKDIlPuYRIR.........s...........L.........o.E....p.E................t................p....p.....K.........lsKElp+LRpFEpuLlptY+tY......	0	74	120	178
+7369	PF07541	EIF_2_alpha		Eukaryotic translation initiation factor 2 alpha subunit	Wood V, Studholme DJ	anon	Pfam-B_5125 (release 11.0)	Family	These proteins share a region of similarity that falls towards the C terminus from Pfam:PF00575.	21.70	21.70	24.20	23.60	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.30	0.71	-4.36	78	521	2009-01-15 18:05:59	2004-01-22 14:09:57	7	4	460	17	353	497	94	115.20	34	38.02	CHANGED	-.hacpluasL.ccaG....csY-.AFc.ssspss.plLschp..ls..............................cchtcsLhphhpcplpsptV+lpu.l-lpshs.-Gl-tIK.cAL..psup..phs....scphp........lclphluuPpY..tlpspu.Dh	.........................LappluWs..Lp..c..KYG..............cua-.AF.K.slsc........s........s..l..l.csls..ls..................................c.c.h.t-sLhp.Ip++loPpslKlRADlEls.Caua.-GI-ulK.cAL.+s.up...stu.............scph.................lKlpLlusPhYllospshDh..........................................	0	119	206	294
+7370	PF07542	ATP12		ATP12 chaperone protein	Wood V, Studholme DJ	anon	Pfam-B_6737 (release 11.0)	Family	Mitochondrial F1-ATPase is an oligomeric enzyme composed of five distinct subunit polypeptides. The alpha and beta subunits make up the bulk of protein mass of F1. In Saccharomyces cerevisiae both subunits are synthesised as precursors with amino-terminal targeting signals that are removed upon translocation of the proteins to the matrix compartment [3].  These proteins include examples from eukaryotes and bacteria and may have chaperone activity, being involved in F1 ATPase complex assembly.	20.50	20.50	20.70	22.80	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.67	0.71	-4.16	100	585	2009-01-15 18:05:59	2004-01-22 14:27:18	6	9	548	7	318	554	186	126.20	35	43.45	CHANGED	KRFaKcsslt.p.........sssG.asltLDGRsl+TP.u+psLslPocs..LApulAsEW...sAQ..pctIcPtoMPlTpLussAlDtlss...p...............pstlhptlhpYhsoDhLhYRAss...........Ppp.........LspcQsctW-PlLcWspp...ph	......................KRFacpsslt..p...........................scsG..atltLDuRs.l+TP.scphLhlPocs..LAps..lAsEW.....suQ..pc.tIcstsMPlTpLsssAlDtssp...s.........................................................................pptlhcslhcahsTDhlhaRusp.........................spp...............L...hptQpcpW-PllcWhppt.h.......................................................	1	106	183	258
+7371	PF07543	PGA2	DUF1531; 	Protein trafficking PGA2	Wood V, Studholme D	anon	Pfam-B_46790 (release 11.0)	Family	A Saccharomyces cerevisiae member of this family (PGA2) is an ER protein which has been implicated in protein trafficking [2].	24.00	24.00	24.40	24.20	22.60	23.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.19	0.71	-4.38	6	125	2009-01-15 18:05:59	2004-01-22 14:39:42	7	2	105	0	89	97	0	112.90	28	84.02	CHANGED	htpNltsoFup...hohc+WIRlIllVGuYlLIRPY....FhKLusK....spt+cpEKEpAEscstp.......u+lSsNuLRGutstup....h.sE-TD-E.......Esstp.ussSusscWGKsARKRQ++hh+cL.cptEcppcc...t--DcDIpEhL-c	...............sh.tphss...hshpcalRllhIlGuYhllRsa....hh.chh.t+.....tthcphcc-p..tctctt............t..tspth+s..t..t................cp-.......cst....ttsou...tWG+psR+..+.+p........c........h.p...t.-phptp....................ppDpDIt-hLc...........................................	0	13	38	70
+7372	PF07544	Med9	CSE2; 	RNA polymerase II transcription mediator complex subunit 9	Wood V, Studholme DJ	anon	Pfam-B_45625 (release 11.0)	Family	This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator [4]. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter [5].	26.10	26.10	26.20	26.40	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.61	0.72	-4.25	43	187	2012-10-04 14:01:12	2004-01-22 16:04:03	8	1	175	0	129	174	0	82.80	25	51.36	CHANGED	ssphhPtlhshhpphtp.......sshssc-ltstsusl+h+lpcs+shlpplss....ls+oscEQppcIcpLcpplppppplLpcapppst	........................................t..phlPhlhthlpp..............hshcspDlppphssl+p+lpcsRphlpphPs....lcpoh--QppplcpLcpplppKpplLpca+phh...............	0	23	52	96
+7373	PF07545	Vg_Tdu		Vestigial/Tondu family	Bateman A	anon	[1]	Family	The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd [1].	19.40	19.40	19.70	28.80	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.35	0.72	-4.51	3	189	2009-01-15 18:05:59	2004-02-04 14:20:38	9	1	74	2	108	146	0	32.50	69	11.85	CHANGED	pYlNAuCVlFTYFpGDIuShVDEHFSRALsass	...pYlsSRCVLFTYFQGDIuSVVDEHFSRALup....................	0	15	23	56
+7374	PF07546	EMI		EMI domain	Bateman A, Doliana R	anon	[2]	Domain	The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al [2]. This is to stop the family overlapping with other domains.	21.80	21.80	21.80	21.80	21.50	19.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.38	0.72	-3.52	43	529	2009-01-15 18:05:59	2004-02-04 17:48:52	8	46	72	0	259	472	0	70.40	32	10.79	CHANGED	spNhCuhhhppslsh.....spstspshhphhhpsC....hst.tCs..............................paRsha+s....sY+hshchh..ophtacCCPGapt.s	.........................+shCuahs.s+slshh...spstspshhps..hp..C....hst.tCs..............................pYRshhRstY+hshKsl.....ophcW+CCPGapG..p....................................	0	28	49	116
+7375	PF07547	RSD-2		RSD-2 N-terminal domain	Bateman A	anon	Bateman A	Domain	This domain is found in three copies in the N-terminus of the C. elegans RSD-2 protein. RSD-2 (RNAi spreading defective) is involved in systemic RNAi [1].  Mutations in the rsd-2 gene do not effect somatic genes but only germline expressed genes [1].	25.00	25.00	25.80	25.20	19.60	21.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.77	0.72	-3.84	7	25	2009-01-15 18:05:59	2004-02-05 14:53:25	8	7	5	0	22	24	0	86.50	29	13.64	CHANGED	FSssspHhTYsRpluaADhYGhV-sup..ts.ptsssaps.Isls.lsYppstpsLFKssph.hch.ssc-ss-hhpphhpFE-ph	................FSSsspHhTYs+pluauDtYGhV-ls....c...tshcpssVYpspIslss.h..............phcsstpslFKlssh..hc.ptp...s-sspc.ahpphhpaE-p.....................	0	5	6	22
+7376	PF07548	ChlamPMP_M		Chlamydia polymorphic membrane protein middle domain	Yeats C	anon	Yeats C	Family	This family contains several Chlamydia polymorphic membrane proteins.  Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract.  This domain is found between the beta-helical repeats (Pfam:PF02415) and the C-terminal Pfam:PF03797. This domain is excised subsequent to secretion [2].	25.00	25.00	35.80	34.20	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.93	0.71	-4.49	55	594	2009-01-15 18:05:59	2004-02-19 17:21:38	6	15	39	0	64	433	0	177.10	26	16.15	CHANGED	GsLsLccsApLpstu..FoQpsGo.lhhssGosLt........................................................sssssslslssLslsLsSlh..................................................................................sspssshtssssssslo.....loGslsLl-ss.sshY-shsLspsh.phsllplssss..........sstspshssshstssss+YGYQGsWohsWpp.................ssspppslhhsWss	........GsLlLc-sApLpshs..hoQ.ss.Gu.lhhssGosLp..................................................................sssssslslssLslsLsSlh..................................................................................s.s...sssss.....h.....ssssssslo.....l.s.G.slsLlDss.sshY-sh.tLsss...plsllplssst..........pstspstphshs.ts.ss+YGYQGsWohs.Wpp..................stpspoLhhsWp..................................................................	0	9	9	50
+7377	PF07549	Sec_GG		SecD/SecF GG Motif	Yeats C	anon	Yeats C	Motif	This family consists of various prokaryotic SecD and SecF protein export membrane proteins.\	   This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2]. This alignment encompasses a -GG- motif typically found in N-terminal half of the SecD/SecF proteins .	20.30	12.00	20.30	12.10	20.20	11.90	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.36	0.73	-7.54	0.73	-4.42	145	7147	2009-01-15 18:05:59	2004-02-20 10:11:56	9	16	3512	9	1648	5001	3208	30.00	30	6.74	CHANGED	hhhhhspslshGlDhpGGspltlpsppsssh	............hhhhpshsLGLDhpGGspl.lpsc.st..h..........	0	506	1052	1384
+7378	PF07550	DUF1533		Protein of unknown function (DUF1533)	Yeats C	anon	Yeats C	Family	This family consists of several hypothetical bacterial proteins and is around 60 residues in length. It's function is not known.	20.80	20.80	20.80	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.10	0.72	-3.98	25	199	2009-09-11 11:31:05	2004-02-23 11:44:10	6	30	76	0	36	185	3	65.90	24	12.90	CHANGED	spsahpsIsclpl..NGsph.........ptscatlttsst.lplssssFscsGpppIsIKApGYpDsslph	...............................ppahppIscVpV..Nssha....................th.pspspashshss........lpl..s...sssF...p.....s.....G...c....ppIpIpu.cGa.p-hphph......	0	21	32	34
+7379	PF07551	DUF1534		Protein of unknown function (DUF1534)	Yeats C	anon	Yeats C	Family	This family is found in a group of small bacterial proteins. Its function is not known.	25.00	25.00	26.60	25.20	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.44	0.72	-4.43	3	44	2009-01-15 18:05:59	2004-02-23 11:54:40	6	6	10	0	6	46	0	39.00	56	65.19	CHANGED	LSFRTLQRGNAVuDAPRHRSAPRRAFKIGRGASRsAsshsA.spohhR	......LSFhTLQRGNAltDA.RH+SsPRRhhKhGRtAS.+suh...........t...............	0	0	0	0
+7380	PF07552	Coat_X		Spore Coat Protein X and V domain	Yeats C	anon	Yeats C	Domain	This family is found in the Bacilliales coat protein X as a tandem repeat and also in coat protein V. The proteins are found in the insoluble fraction [1].	20.00	20.00	62.40	22.20	19.70	17.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-8.88	0.72	-4.19	22	264	2009-01-15 18:05:59	2004-02-23 14:24:19	6	2	76	0	29	192	0	60.10	42	71.12	CHANGED	pscplsp-hhQhsthcQls...cpplhIcsSpsVsVoToDTpsAlslQshlQshlsl.llplsI	.......p.ssplsp-hhQpophcQls...cpplhIhsSpsVsVTTTDTchAlsIQshLQshlsl.llplsI.......	0	7	19	23
+7381	PF07553	Lipoprotein_Ltp	DUF1535; 	Host cell surface-exposed lipoprotein	Yeats C	anon	Yeats C	Domain	This is a family of lipoproteins that is involved in superinfection exclusion.  Proteins in this family have been shown to act at the stage of DNA release from the phage head into the cell [1].	20.10	20.10	20.70	20.20	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.24	0.72	-4.09	18	773	2009-01-15 18:05:59	2004-02-23 15:58:35	6	18	375	0	116	573	23	47.10	43	32.24	CHANGED	shc.psALcKAKsYucohpMS+pulY-QLsS-......aGEKFTpEpAQYAlDsL	.......c.psALppAKsYt.p.h.hp.MSKpulY-QLoS-.......hu-+Fos-pAQYAlDpL......	0	31	69	104
+7382	PF07554	FIVAR		Uncharacterised Sugar-binding Domain	Yeats C	anon	Yeats C	Domain	This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin (personal obs: C Yeats). This is further evidenced by [1]. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as Pfam:PF05089 further supports this proposal. It is found in the  C-terminal part of Swiss:O82833, which is removed during maturation  ([2]). Some of the proteins it is found in (e.g. Swiss:Q9RL69) are  involved in methicillin resistance ([3]). The name FIVAR derives from Found In Various Architectures. 	21.30	10.80	21.30	10.80	21.20	10.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.73	0.72	-3.65	225	12786	2009-09-13 16:22:53	2004-02-25 16:52:28	8	504	697	8	341	12670	23	49.90	26	19.54	CHANGED	l....spssshptttph.....hshssstpsshspAlstApsllsp.ss.....sstpplspA	........................................l.tspsssptspsY...................hsAsssppsAYssAlssAcsllsp.ss.sss.hstspVspA..................	1	168	208	297
+7383	PF07555	NAGidase	Hyaluronidase_2; 	beta-N-acetylglucosaminidase 	Moxon SJ, Bateman A	anon	Pfam-B_4394 (release 12.0)	Family	This family has previously been described as a hyaluronidase [1,2]. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity [3].	25.00	25.00	26.50	26.00	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.04	0.70	-5.51	30	535	2012-10-03 05:44:19	2004-02-26 11:24:06	8	42	380	54	170	546	259	293.30	33	30.05	CHANGED	RGsIEGFYGpPWSp--Rh-hhcFhGchKhN...TYIYAPKDDPYHRp.pWR-.YPs-El.sclp-LlcsAscs+lcFsaAluPGhsls.....ao...spcDhpsLhsKhcplhchGVRsFulLhDDIs.t.................sssupsQscLlNclpccahps+tsshs.....LlhsPTEYssstsss.......YlpsLscpLsssIplhWTGssVl.sspIohpshcph.......ssshtRsshlW.NaPVNDa..sps+LhhGPhts.pcssl..s..plsGhVoNPMppucASKlAlau....lADYsWNtpsa..DspcuWppuhchlss..............sss-slthFucp.	..............................................RGhlEGFY........Gp...PWopcpRhchhcahuchchN....oYl..YAPKDDshHRt...pWR-hYs......t-...........c..h.....pp...........lppLlpsupcsclcFlaAluPGhs.hs.........as........tpp-hpsLhpKhcQlh....p.h.GlRpFulL....hDD....Is.......................pshupsQsplhNcl.pphs....p.........c..................hlhsPT..cYssshsss.................................YLpslucpLs.s.slplhWT.GspVh.ssplo.ps.lpph...........sphh.p..RsshlW.NaPsNDa...........spp+....Lh.LGPhp......s....p.........sssl...s........plpG...llsNPMp.ph-s.....Sclulas....hAsa.Ws.tsh...ssp.pshpt.shp.h........t.t.th.............................................................................................	0	53	84	131
+7384	PF07556	DUF1538		Protein of unknown function (DUF1538)	Yeats C	anon	Yeats C	Family	This family contains several conserved glycines and phenylalanines.	20.70	20.70	22.10	22.30	19.90	20.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.31	0.70	-5.25	72	585	2009-01-15 18:05:59	2004-02-26 17:09:14	6	2	271	0	199	528	359	210.10	35	83.88	CHANGED	IllllhhFQhlll.+tshsshhpllhGhlhVllGLslFLhGlchGlhPlGcthuptlsp.....................hss....hhhllhFuFhlGFusTlAEPALhslutpsppVou..GtIs.........thslhhsVAlGVululuLGhhRIlh.GhPltahllsGYlllllhohFuP.....pthlulAaDSGGVTTuslTVPllhALGlGlAss.lp......GRssllDGFGLIAhASlsPllsVhlhGhlh	..........Ihhllhhhphhll....phshtp...hhpllhGhlhlhlG.LslFLhGlchuhhPlGcthGptlsp............................................................................hsp......hhhll.hhuFhlGFssTlAEPulhsluppspplos..GtIs...........ttslhhslulGVululsluhhRIlh.GhslhahllsGYlllllloh..asP......p.hlulAaDSGGVTTGslTVPhlhALulGlAus.lp...............u+.ss.hhDGFGllAhsSlsPlluVhlhGll.h.....	1	97	169	191
+7385	PF07557	Shugoshin_C		Shugoshin C terminus	Wood V, Studholme DJ, Watanabe Y	anon	[1]	Family	Shugoshin-like proteins contain this conserved sequence at the C terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered [1]. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres [1].	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-6.83	0.72	-4.46	25	261	2009-01-15 18:05:59	2004-02-26 17:34:01	6	9	200	0	173	252	0	25.90	48	4.60	CHANGED	s.uRspR.Rsshsl.sYpEPoLpsKhRRs	.............sRspR..Rspts.V.sYpEPsLpsKhRRs..	0	42	82	135
+7386	PF07558	Shugoshin_N		Shugoshin N-terminal coiled-coil region	Coggill P	anon	Manual	Domain	The Shugoshin protein is found to have this conserved N-terminal coiled-coil region and a highly conserved C-terminal basic region, family Shugoshin_C Pfam:PF07557. Shugoshin is a crucial target of Bub1 kinase function at kinetochores, necessary for both meiotic and mitotic localisation of shugoshin to the kinetochore [1]. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly [2]. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [3].	30.00	30.00	30.00	31.90	29.90	29.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.98	0.72	-4.25	24	155	2009-01-15 18:05:59	2004-02-26 18:24:25	6	3	123	1	92	154	0	45.80	30	8.09	CHANGED	l+ppahpQNpplu+tNShlph+lpplcsclocLlsENhsLRpph.t	....lKc+ah+pNpElu+pNSh.sh+l..pplcscsopLhsEphslRppsl.....	0	15	37	67
+7387	PF07559	FlaE		Flagellar basal body protein FlaE	Yeats C	anon	Yeats C	Family	This family consists of several bacterial FlaE flagellar proteins. These  proteins are part of the flageller basal body rod complex.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.13	0.71	-3.48	180	2146	2009-09-11 11:36:52	2004-02-27 10:17:02	9	15	1789	5	472	1518	458	131.10	26	27.96	CHANGED	hss...ssssoas..sooh.slYDSLGss.........HslshaFs.K...................................sss.....ssW..plhssss.............................................................................................................................ss.s.ssslsFs.s.......sG...p....l.........................................................................sssssshsssssssuuss.p...............lslsh.........s.............................ssTQau....us..t..ssshs...Q.DGa	........................................ss.p.o.as....h.sso.l.slYDS.....hGs..s.........HslslYFsK....................................................................sus........Np..W.....pshs.p.ss.........................................................................................................................................................................................................................................................................................................................s.s.ss.s..shs.ssslpFs..s.........sG......sL...............................................................................................................................................................................s...ss..s.......s...s.....s...hs....s..s.....s.h....s..G.As.sts............hslsh.....................s..........................................................uh.T.Qhs......us...s.....lsshs.....p.sGY....................................................................................................................................................................................................................................................................................	0	138	279	374
+7388	PF07560	DUF1539		Domain of Unknown Function (DUF1539)	Yeats C	anon	Yeats C	Family	\N	21.10	21.10	21.80	24.40	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.50	0.71	-4.26	13	46	2009-01-15 18:05:59	2004-02-27 12:06:41	6	2	13	0	9	26	0	130.90	32	29.47	CHANGED	APpsssFLcSLhpsosppWpshpc........LcspIp......................cLsss..lcssWtpILchlsst......spsphsuc.spslhhuhha+LhphLp.....sPsIsp-+KpplLpaIuSYus.sCsPTWlEshhpElptlaNpp-susshl	..............sPtss.FLpSLhpsssppWshhap........LcspIp......................plpss..hcssWtsIlphlsst......ppsp.psc.sushhhuhha+lhthLp.........ssslop-+KhphLs.IuSYss.tCsPTWlEshhpElptIaNpp-pshs.l....	1	0	0	7
+7389	PF07561	DUF1540		Domain of Unknown Function (DUF1540)	Yeats C	anon	Yeats C	Family	This family has four conserved cysteines, which is suggestive of a metal binding function.	22.10	1.00	22.10	5.70	21.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.82	0.72	-3.92	185	1099	2009-11-12 09:41:43	2004-02-27 12:20:09	6	2	553	0	243	664	14	41.40	32	75.43	CHANGED	lpCpVssCta.Npspp.CsAspIpV.....u....................spu....ppspp.Ts..CtTF	...ltCpVssCsa..N.p..sst.Cs.Aps.IpVt....u.....................tpu.tpstpTs..CtTF.................................................	0	125	200	227
+7390	PF07562	NCD3G	ANF_assoc; 	Nine Cysteines Domain of family 3 GPCR	Liu XH, He Q, Studholme DJ	anon	[1]	Family	This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the Pfam:PF00003 in several receptor proteins.	25.40	25.40	25.50	25.70	25.20	25.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.97	0.72	-4.25	119	2732	2009-09-14 23:23:15	2004-02-27 13:11:15	9	24	148	9	1676	2202	0	52.60	41	6.74	CHANGED	PhSsCSpsC.sGptK...th.pGpshCCacChsCsssphssts.Dth.pChtCs.p...Wu	..............PpSlCS.psC...t..PG.hRK................th.cG..ps.....CCacChsC.s-sc...hs.....sp......s......Dt......pCh...p..Csts.pas..........................	0	120	276	1069
+7391	PF07563	DUF1541		Protein of unknown function (DUF1541)	Yeats C	anon	Yeats C	Family	This family consists of several hypothetical bacterial and occurs as a tandem repeat.	25.00	25.00	52.70	35.20	21.80	17.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.80	0.72	-4.29	25	328	2009-01-15 18:05:59	2004-03-01 10:17:26	6	3	151	8	58	283	0	52.60	52	56.99	CHANGED	psGspVllsAsHMcGMcGAcAsIcuAhcTTVYhVsYsPTsGGcpVcNHKWVsc	....sGspVhlpAsHMsGMKGApAsIcuAhc.TTlYsVsYpPTsGGcpVpNHKWVsp.......	0	16	43	51
+7392	PF07564	DUF1542		Domain of Unknown Function (DUF1542)	Yeats C	anon	Yeats C	Domain	This domain is found in several cell surface proteins. Some are involved in antibiotic resistance (e.g Swiss:Q9RL69 and Swiss:Q9LCJ9) [1] and/or cellular adhesion (e.g. Swiss:Q931R6) [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.37	0.72	-3.96	112	9196	2009-01-15 18:05:59	2004-03-01 17:55:50	6	178	465	0	319	6747	7	70.10	27	29.11	CHANGED	pppstIssssssTsEEKptAhsplspthppAhssIspAposspVsps......pspulssIp....sl...pss..spt....KssApp	..................phstIss..sssuTsEEKpsAhsplspth.spAhpsIs..s..A..s...T...........ssp...........Vsps...........cspulssIp......sl.....pss...sph......KtsAp.....................................	0	58	119	228
+7393	PF07565	Band_3_cyto		Band 3 cytoplasmic domain	Bateman A	anon	Pfam-B_1004 (release 3.0)	Domain	This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk). [1]	23.20	23.20	23.20	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.51	0.70	-4.87	32	1074	2012-10-02 23:31:29	2004-03-02 15:25:32	8	13	122	4	398	964	12	235.00	42	26.14	CHANGED	-l-csscRWu+PHVusLoa+SLhELR+sltpGsVLLDLctsoLsslActll-phlhpsplcspsRcplhcsLLh+Hp.......H.s-.........t.t..hshhhshushsp..t.................................t.sps.hs.spshtsp..tpttph....................................................................................phpphp.phhcKIPpsuEAosVLV.........GpV-FL-pPslAFVRLppuVh....LpulhEVPlPsRFlFlLLGP.sssshsYHElGRuhATLMoDclF+psAYtAcsRcDLLsuIc-FLDsulVLPPu-hssp	..............................................................................................................................................................cVEcsu-RWuKPaVAoLSh+SL....hELRp....sl.p...GslhLDhctso..........L.tl.................s.c...ll-p..l...ssplpsp...R.tpVhpsLLh+Hp.......Htsc......................hshhhS..hushsp...u.p.p.................................................................t..............t....s.......h..............tt...t..................................................................................................................................................t.phpphp.phhc.KI.P.tsAEAos.VLV................................GpV-FL-p..PhhA.F.VRLppA.Vh....L.suls.........E............VP..l.....Ps...RFLFlLLGP..tups.pY.H.E.IGRuhATLMoDc.........l.FH-sAYpAccR...........pDLl.uuI-EFLDpshVLPPGEh-s.s..................................................................	0	68	97	223
+7394	PF07566	DUF1543		Domain of Unknown Function (DUF1543)	Yeats C	anon	Yeats C	Domain	This domain is found as 1-2 copies in a small family of proteins of unknown function.	21.70	21.70	21.70	22.10	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.66	0.72	-4.45	44	345	2009-01-15 18:05:59	2004-03-03 13:14:42	7	2	198	16	80	277	231	53.00	32	53.00	CHANGED	splEhHDltaVVupslcsshspl+ppW....hGstpuLHlDuatplcpl....DGaclp......L	...t.hElHDhthsVusshp-Ah.ph+psW....hsst.pplHhDshpsVcss......tuhpl.....................	0	21	36	60
+7396	PF07568	HisKA_2		Histidine kinase	Studholme DJ	anon	BLAST	Domain	This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536. It is usually found adjacent to a C-terminal ATPase domain (Pfam:PF02518). This domain is found in a wide range of Bacteria and also several Archaea.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.61	0.72	-4.12	91	1811	2012-10-11 19:05:54	2004-03-03 17:01:18	7	326	1027	0	823	2166	242	75.40	34	13.93	CHANGED	EIHHRlKNNLQlISSLLsLQucphpsccs......hcsh+ESQsRVhShAllHEcLYcup...shcslsFusYlpcLspsLhpoY	......ElHHRVKNNLQsluSLLpLQ.u..cp.s.....p.s...s.c..s.......+psLp.-.utsRlpulAhlH-.t.Lh...ps.t......c.....p.........p...lshs.p.hlpplhppl....h...................................	0	296	586	667
+7397	PF07569	Hira		TUP1-like enhancer of split	Studholme DJ, Wood V	anon	Pfam-B_7106 (release 12.0)	Family	The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin. These proteins also contain Pfam:PF00400.	20.30	20.30	20.30	21.60	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.40	0.70	-5.13	34	350	2009-01-15 18:05:59	2004-03-04 09:39:21	6	28	250	0	246	360	0	188.80	25	21.31	CHANGED	sG+RlhPsllLsusssh..LEspupa.LhslTusGhLalWNlpptpshhss..SltslLs.s....t.....spusslotsplo.ppGhPllTLSNGcuYsasssltsW.hlo-sW..WuhuSpYWssh..............ssstst......................................ssssuhlshLEp+Tssphhhp...Gphh.hp+h........h+shl.ccGhEshE....psloluHLEN+ltsuhhLtupcEa+taLhhYs++Lupp..........Ghcs+lcElhppL	........................................................sG+RlhsslhLsu....hsh..lc.s...p...spa..lhslTssGhhhlW......s..lpp......t....ps......hhts.............S......lts.l.Ls...........................sssssl..spst.l.s..pp.G....h.P.l.l.s..L........o.......s..G.c.u......Yhas.shtsW.hlu-t....hh.supahssh.......stt..................................................ptu.lshlptpsppth....................................tshh.hps.pthp....p.holuaLEspltsuhhL.tutpE...a+haLhhYs+hL.stp..........G..c.+....lc-lhptL................................................................	0	78	140	211
+7399	PF07571	DUF1546		Protein of unknown function (DUF1546)	Studholme DJ, Wood V	anon	Pfam-B_3691 (release 12.0)	Family	Associated with Pfam:PF02969 in  Transcription initiation factor TFIID subunit 6 (TAF6).	20.30	20.30	20.50	20.70	20.20	18.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.00	0.72	-3.87	29	394	2009-01-15 18:05:59	2004-03-04 11:00:50	8	7	260	0	270	386	3	93.80	35	17.62	CHANGED	lLTCllu+pL...sspss......................hcppauLR-hAAsLLuhIs++ausshssLpP..Rls+ThlKshlDs........s+.shuoaYGAlhGLpsl.Gs-sl+hlllPpLpsa	...........................................llTCllu+pL..sspss..................................................hcs.HasLRDhAApLlup.Is..+p..auss.....hssLps...R....ls+ohhKshhDs.......................p+..shsopYGAlhGLttL..G..csl+hlllPpLp...................	0	93	145	215
+7400	PF07572	BCNT		Bucentaur or craniofacial development	Studholme D	anon	Pfam-B_10149 (release 12.0)	Family	Bucentaur or craniofacial development protein 1 (BCNT) in ruminents has a different domain architecture to that in mouse and human. For this reason it has been used as a model for molecular  evolution [1-3]. Both bovine and human BCNTs are phosphorylated by casein kinase II in vitro [4].	22.20	22.20	25.30	24.20	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.01	0.72	-4.04	37	295	2009-01-15 18:05:59	2004-03-04 11:32:09	7	6	263	0	214	299	2	78.80	36	26.19	CHANGED	K+......shlsplhutht......KcpKLsTLEKS+hDWsuas-cc.GIp....-ELphHs+.K.......cGYLs+p-FLsRs-s+p.Ep.+phRhpph	..................tp......shhsplluphs......KptK....loTLEKS+lDWssah-cc...GIp..........-E.Lph..+s+uK................-GYL-+psFLpRs-t+p.Etc+phRhpt.h.............	0	71	117	177
+7401	PF07573	AreA_N		Nitrogen regulatory protein AreA N terminus	Studholme DJ, Wood V	anon	Pfam-B_11486 (release 11.0)	Family	The AreA nitrogen regulatory protein proteins (which are  GATA type transcription factors) share a highly conserved N terminus and Pfam:PF00320 at the C terminus.	21.50	21.50	21.60	22.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.23	0.72	-3.42	7	19	2009-01-15 18:05:59	2004-03-04 13:21:54	6	2	18	0	9	21	0	82.60	56	9.91	CHANGED	MSGloh.GGGssusRPTtsAs.h.o..ssADADR................osQLSDDFShsSPhSssDSupspDGLLpDSLFPEW+sGAPRsGh-SPDE	........MSGloh.GGG.s..GusRPTpsAshh.oh.s.ADADR.Sssp..p........oSQLSDDFShGSPlSPsDSSpApDuLLpDSLFPEW+sGsPRs.GhDuPDE	0	1	2	6
+7402	PF07574	SMC_Nse1		Nse1 non-SMC component of SMC5-6 complex	Studholme DJ, Wood V	anon	Pfam-B_24547 (release 11.0)	Family	S. cerevisiae Nse1 (Swiss:Q07913) forms part of a complex with SMC5-SMC6 This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism [1,2].  It is conserved in eukaryotes from yeast to human.	22.00	22.00	22.30	22.40	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.14	0.71	-4.69	9	296	2009-01-15 18:05:59	2004-03-04 13:40:24	8	7	238	1	199	289	2	168.00	25	61.36	CHANGED	-s+RthLQslhs.+Ghlpps.ltphhsslsspps..s.h.ppt........hLssaVsplNpclpsLshclctspa............................ssutpaYValNssssstschuTsaossElpahKthl-tlspppshhtt........lshlstsscltupt.pp...............................................lt.ocsppLLpchsp.tWh.hohcschsLshRsLlEh	.......................cRthLQhhhs.+us.hp.pp....hptlh...t...th...hphpp....t.....t.............................ptlp.salssINstl.psht...hcI+pshp................................................p.suphhaul..VNhsss...s.h.o.p..hA.T.....sastsE........lshh+phl-tlhp..s.ts...s...tpt........s.hls.hptlphtp..tp.....................................................................pcsEphLpphlpptWh.h..p..pp.G..asLssRslhEh........................................................................................................	1	61	104	158
+7403	PF07575	Nucleopor_Nup85	Nuceloporin_Nup85; Nucelopor_Nup85; 	Nup85 Nucleoporin	Studholme DJ, Wood V	anon	Pfam-B_55990 (release 11.0)	Family	A family of nucleoporins conserved from yeast to human. THe nuclear pore complex is a large assembly composed of two essential complexes: the heptameric Nup84 complex and the heteromeric Nic96-containing complex.  The Nup84 complex is composed of one copy each of Nup84, Nup85, Nup120, Nup133, Nup145C, Sec13, and Seh1. The structure of a complex of Nup85 and Seh1 was solved [3]. The N-terminus of Nup85 is inserted and forms a three-stranded blade that completes the Seh1 6-bladed beta-propeller in trans. Following its N-terminal insertion blade, Nup85 forms a compact cuboid structure composed of 20 helices, with two distinct modules, referred to as crown and trunk [3].	19.70	19.70	19.80	19.80	19.20	19.50	hmmbuild  -o /dev/null HMM SEED	566	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.93	0.70	-6.30	20	368	2009-01-15 18:05:59	2004-03-04 14:56:35	8	8	253	16	255	381	1	430.50	18	69.60	CHANGED	sshlYhlppstt.hposphRpllsEsaplFhsLQphc.......t.spspps......pal.plspsYRSllpsshpplpph.th...hhpc.tphpp......plolLhslcslWp....LhEhLah-ssstuslltpLL-Wl.Rhcspss-phsp.........-lLtppc.....slpcpssaWclVssLlLpGhh-pAhphL.tpcuph.........sspshhcshtsLLpphPhhp..tt.........shp-hcppWccW+spspc.......plpssshsspspLEsllpllsGsccslhp....hsssWYEhhsuhLLYhpP....osc.hE.LptYAppslsta..............s.ssspsh-plhlslhptclhpVltphpph.sshWhsAHlsDLl....-+sGlLp......spp.phu..............sshREaLLh-YApsLhS..c+oLWQlulsYlshssptG....+shlEhllsRlPlpTscct.+hLplCcphpLs-lsppIhKlhup+sLcps+hGsALsWhh+ApDhshlshlophlh.....cchspcGshhs.-llssluss.....................hlu.spLoFLupYp-Fa+hhpp.......ccatcAscLLlsLhpsphsPppaWhsLLsDslsLLp...ccsh.hssppThpllcsLEcht	.................................................................................s............................................................................................................................................................................................................................l....L.hpW..h.p...c.............tp..t.............phh..t..............tp..taW.p.h.l..hlh.G..hp.shthL...ttt.............................thhp.h....tlhpphP..t......................................................................th...th..p..hp...h......tp...........................pt.....h.t.......tlp.lhplh...hGp....t.th.t................p.sWhchh.shhha...s....................................p....hht..hp.h..........................................s..p.h.c.hh.hshh.phshtthlt.....h..........p....h...s.hh...ssthh-lh....................pht..thlt.................s............................shc.c.h...lhpYut.Lhs.............ppth..........Wplulthh......s....h..s....p.s.........thhlp.hl..+h..sh.....p.....o.....p...........p............p.......h......chl................pl...............st.pht.h..p.........pplhchhu.p............h....h.p..p.t.p......hG...pAl.hh.......h............p...........ups............h...........hhp.............l.....sp.h.hh.....................pph...ps....................t.hl..t.lhst..............................................hht...tLsh....h....s....phhcFhp......hhtp............................tph......tu......ph..Ll...lh................................................................................t..............................................................................................................	0	86	137	210
+7404	PF07576	BRAP2		BRCA1-associated protein 2	Studholme DJ, Wood V	anon	Pfam-B_5419 (release 11.0)	Family	These proteins include BRCA1-associated protein 2 (BRAP2), which binds nuclear localisation signals (NLSs) in vitro and in yeast two-hybrid screening [1]. These proteins share a region of sequence similarity at their N terminus.  They also have Pfam:PF02148 at the C terminus.	20.30	20.30	21.60	20.60	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.27	0.72	-4.48	8	297	2012-10-02 20:46:34	2004-03-04 15:41:04	7	12	249	0	215	297	3	104.60	28	17.78	CHANGED	ppssppphpsss.sthhslhsVsshhssc.lhphsuhppp.Icpl+ll+DusPNpaMVLI+F+sppsAhsFYppFNG+sFNslEs-s.CHllaVpcVEhspp....ssssss	..................s..........pp.ot.hhsl.hssshhhssc.L.h..hh.s.s..hppslp.p.h+l...l+..........c.up...s.NpYMVLlKFcspps.AcpFhppaNG+.F.NSh.Es.-s.C+llaVpplphpps..........s.....................	1	62	116	175
+7405	PF07577	DUF1547		Domain of Unknown Function (DUF1547)	Yeats C	anon	Yeats C	Family	This family appears to be found only in a small family of Chlamydia species.	25.00	25.00	48.60	25.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.73	0.72	-4.30	17	329	2009-09-10 18:55:26	2004-03-08 13:41:42	6	4	37	0	10	241	0	60.10	42	19.82	CHANGED	cILspVRpHLDsVYsupsst.stt....NQsLGslI+shE.ssTupsTllsshpssssshuop	DlLusVRtHLDhVYPu-ssssops....NQsLG-llpchEspGTupcTllos.puusspss............	0	3	3	7
+7406	PF07578	LAB_N		Lipid A Biosynthesis N-terminal domain	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of a group of Chlamydial Lipid A biosynthesis proteins. It is also found by itself in a family of proteins of unknown function.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.38	0.72	-4.06	10	310	2012-10-03 12:15:12	2004-03-08 16:42:16	6	3	227	0	109	288	189	71.50	40	47.27	CHANGED	lGhluphFFosRFslQWhhSE+ppcSslPtsFWhhSllGusLhLlYulh..puDsVhlLsauhsLllYlRNLpl	..lGhhuQhhFuhRFllQ.Wl.h.S.E+.t.p+SllPhsFWhhSl.hGuhhhLsYulh..+pDs.VhlLupuhulhlYhRNLh............	0	33	74	91
+7407	PF07579	DUF1548		Domain of Unknown Function (DUF1548)	Yeats C	anon	Yeats C	Family	This family appears to be found only in a small family of Chlamydia proteins.	22.20	22.20	23.70	44.80	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.65	0.71	-4.05	10	36	2009-01-15 18:05:59	2004-03-09 10:28:22	6	2	13	0	8	22	0	133.10	39	23.45	CHANGED	Rspc....EWHpIsuFKHh+GcpLGL.hDsLuc.LsshTlphTohphhpp+spYphlhppFlssY+sSsssLlpalhsQhlsSSp-lpsulpsaLL-sl.sslslPEs.c+sslls-lFY.D-s.YEhspEGIlYLLlh.GII	.............ppcEWHhhsuhKah+G+pLGLsh-pLsp.LsshTlp.TuhphhpppppYphlhspFlssYpsSsssLlshlhpphhsuos-hpsslpsalL-pl.cslslPEs.t+sslhpslFa.D-p..Y-hsppuIsYLLhh.sII.....	0	0	0	6
+7408	PF07580	Peptidase_M26_C		M26 IgA1-specific Metallo-endopeptidase C-terminal region	Studholme DJ, Yeats C	anon	Merops	Family	These peptidases, which cleave mammalian IgA, are found in Gram-positive bacteria. Often found associated  with Pfam:PF00746, they may be attached to the cell wall.	21.50	21.50	21.90	25.30	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	737	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.43	0.70	-6.23	18	836	2009-01-15 18:05:59	2004-03-09 12:20:28	9	67	284	0	22	447	2	617.60	40	40.45	CHANGED	spltEYslssh.sllYTPNtlh+D.pssLlssVhscLpuVpLpSs..sl+plL...s....hss-s.....s.......lc-LYL-ESFscVKssLschl+KLLps-sphhpss.psspphllcKIccNKsAlhLGLTYLNRaYshKYschslK-LhhFKPDFaGK.ssSsLDpLIclGpSu.sNL+ucpslpsYsphlusshGps.cLasaLch.R+LFsspps.N-WFKcsoK..AYlVEppSsl.EhpsKp..........htlY.....Dplsss..pappMlLPLLTLp.cpplFlISshsTluFuuaE.....+Ytpss.......cEtpphhccplccsAccQRsahDaWYRlhs-ss+-KLh+S.l.....VaDuashsssshh.c+hutsstcsshssl+EFF....GPsG+aathp.uh.GAYAsGp..........sVYahshchlsca.GsSsaTHEhTHssDphIYLGGaG+RpGhGsEsaApGLLQoPssssss....sLGlNhsac+psDss....plashDP.s+hpoccDlcpYM+Nh.DslhhLDYLEupullsphsss.pspWF+Kl-pcahcs........sspsathstVRsLTsEEtp..pLsSl-DLlDNsllopRshsuNt.......ca..csuYholshhusIYuuhsoSpGuPGslhF++sAFclhuhhGYccGFlsYlSNpYcspApppGpsh...........loDchllcKV.sGpaso.hp-FKKAha+EhhsKtp..slsslTls..........spTIsoas-LpsLhccAVpcDhtt....lpssssspp....stsppLKptlaKAhLcpTDsF..+oSIF	............................................................................pltEYslssh..sllYT.PNhh..ps..hspllpplhspLppVph.St.....tlpphl...s....hptps......p.......................................hpc.LYL-EpFspsKtpLpp.lppll.p.s-.tt.h..ss.pss.thlhcKl..cpNK..ttlhhuLTYLpRaYshpasp..hshKcLhha+..DFa..Gc.ssssLDp.lIplG..............Su......pNLhuppshpsYt..lutthspt.sLhshLch.hclFhspps.N-WFhptsK..sYlsE.p..Ss..-htscp..........htla..............Dtlsss....h....at.p......M..lLPLLsL...ptplalISshsohuauua-.....+Ytppp.........pp.tp.hc.pphccsActppsahDaW.+lh.sps+p+Lh+s.......la.Ds.hp...h...sst.t.....h....pth.h..sph.p.....p.s......ssh+pha....GPhsph...h.hp.th.GAhA.sh.........tVhahshchl.sc..GhssaTHEhTHssDp.lYhGGat+RpGhssEh....aApGhLQsPspssss........slslN.hhctppsss................ph.shsP.pchpstt-lppYh+sh.DslhhL-aLEupullt.....p.ptt.p.phh+Kl-pphhps.............tsht.hshlRpLst-Ehp..pLsShssLl-pshhop+t...ss............sa..psuYhslp..hhssIYuu.ssppGsPGsl.h++.sachhuhhGYccGFlsYlSNpYcppAcp.pGcsh...........loDchllcKl..s.....spapo.htsFKKshapEhl-Khp...slpslT.ls............spoIs.shpcLppLhscAVpcDht...........hhp..t...p........ptshpLKptlaKthLppTssF..psSIF.....................................................................................................	0	3	9	12
+7409	PF07581	Glug		The GLUG motif	Yeats C	anon	Yeats C	Family	This family is found in the IgA1 (M26) peptidases, which attached to the cell wall peptidoglycan by an amide bond ([1]). IgA1 protease selectively cleaves human IgA1 and  is likely to be a pathogenicity factor in some pathogens ([2]). This family is also found in various other contexts, including with Pfam:PF05860. It is named GLUG after the mostly conserved G-L-any-G motif.	20.50	18.00	20.50	18.00	20.40	17.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.22	0.73	-7.63	0.73	-3.40	110	564	2009-01-15 18:05:59	2004-03-09 12:56:16	7	70	210	0	192	551	145	27.50	37	4.06	CHANGED	sstslGGllGtstt.........uslpsssusu..sls	......sttlGGLVGhsht............usIpNuhAoG..sVs......	0	77	158	178
+7410	PF07582	AP_endonuc_2_N		AP endonuclease family 2 C terminus	Studholme DJ	anon	[1]	Family	This highly-conserved sequence is found at the C terminus of several apurinic/apyrimidinic (AP) endonucleases. in a range of Gram-positive and Gram-negative bacteria. See also Pfam:PF01261.	20.60	20.60	20.60	20.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.51	0.72	-4.42	56	878	2009-01-15 18:05:59	2004-03-10 15:21:13	7	3	742	7	289	741	345	53.10	34	16.20	CHANGED	-FcsIFSpLsphGYsGhsslEWEsslhctppGApEussFl+ch..lIpssstuFDsh	.....atslhSpLtthGYDGhlSlEaE.....D.....sl.....hs.....s-...c.....Ghpcusphl+sh...I.spstsh..h...........................	0	96	195	254
+7411	PF07583	PSCyt2	DUF1549; PSC2; 	Protein of unknown function (DUF1549)	Studholme DJ	anon	Blast single linkage clustering	Family	A family of paralogues in the planctomyces.	29.80	29.80	30.00	30.40	29.50	29.70	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.39	0.70	-4.83	176	580	2009-01-15 18:05:59	2004-03-10 15:58:43	6	38	66	0	247	688	957	204.70	35	22.91	CHANGED	ssIDpFlhp+L.cpt.slpPustA-.cpsllRRlshDLsGLPPT...scElcsF.....ls...D...p..u...ss..u.acc....lVD+....LL......sSP.c....YGE....+WupcWLDlsRau-opGh...p.c.......tp.ssatYRDaVlcuhNcshPYDpFlpEQLA.........GD.l...................t....................................pth........h.........................AouFht.t....................hptchh...sDtssssupsFLGloltCApCHcHKa.DPlopcDYYphtAaFs.sspttstt	....................................sIDpalhs.+Lc.pp...s..lpP..u....stAcc.psllRRlshDLsGLPPT..scElcsFls........D...s..s....ss...u.hcclVD+....LL......uSP.c....YGE....+WuppWhDlsRau-opGh.....p.s........p.....statYRDaVlcu.hNpshPaDpFlpEQlA......GD.l..s.......st...........................pph......h..........AouFhphs.............t............php.h...s-tssssupsFLGlo.ltCApCHDHKa.DP.l...........spcDYYphtAhFsssp....th.......................................	0	211	242	246
+7412	PF07584	BatA	DUF1550; 	Aerotolerance regulator N-terminal	Studholme DJ	anon	Blast clustering of Pirellula proteome	Domain	These proteins share a highly-conserved sequence at their N-terminus.  They include several proteins from Rhodopirellula baltica and also several from proteobacteria. The proteins are produced by the Batl operon which appears to be important in pathogenicity and aerotolerance. This family is the conserved N-terminus, but the full length proteins carry multiple membrane-spanning domains [1]. BatA ensures bacterial survival in the early stages of the infection process, when the infected sites are aerobic, and is produced under conditions of oxidative stress [2].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.79	0.72	-3.79	193	1151	2009-09-10 21:46:21	2004-03-10 16:07:12	6	14	818	0	405	993	385	77.20	25	14.72	CHANGED	M..............Fh..sPh.hL................huLl.hlsl..lllahhhht+.pph..tasulphL.tphtppppp......phpphhLLlLRlLhluhlllAlApP	....................tFtsPh.hL.......hhLl.hlsl.....h..h...l...h..h...h...h..t...p+tpph....pFssh...plL....tplhspppp.......hp....a....l..hhh.LplLslshlllAlApP..................................	0	168	307	362
+7413	PF07585	DUF1551		Protein of unknown function (DUF1551)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of proteins identified in Rhodopirellula baltica.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.99	0.70	-5.57	14	57	2009-01-15 18:05:59	2004-03-10 16:13:21	6	2	20	0	35	65	47	311.20	17	65.17	CHANGED	pAEhlhhhpcGss.ssLlo.ss......s.sssss.s..sspsLhusphs.c..hpuGhRlphGhhhss.sshulEhpaaslts.suuhss...ssuphshhutPh.p.Tshss...ssuphl..h.s...........sthslpssschtuhEhNh.....Rhthss.........tts.phshLsGaRahpLc-tLphsps.sshst............shs..sso.l...s.p.shsscNphaGsQlGhphphpp.sthohsuhhKsulsss+tstsspsstshs.s...................s..sssshspsphuhlsEhslshtaplspshslplGYphlahssVshAs...cpIspshsssss............spssss.spsohhhpGlshGhpapa	..............................................................................................................................................sh.ss..s.p..hpsGhRhphuh..hts....slphph.....hhh..p.ptshts.....sstththht.tsh...s.hsh............tts.h.........................................sthphphpschh...uh-hsh...........ph.h......................tthphphlhGhRahplc-plshsssspt.st..............................................................s..sss.h......................p.shpspNph..a..Gs..QlGhchphph.spasls.shsKsul..hsNctphshp.spsshsts..............................ts......sstspsphuhss...-hslsh............tap..l...spphshphGYphlhhssVshu....pplstshssss................sth..ppsshhhpGhshGhph.a.......................................	0	28	32	32
+7414	PF07586	HXXSHH	DUF1552; 	Protein of unknown function (DUF1552)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of proteins identified in Rhodopirellula baltica.	19.80	19.80	19.80	20.20	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.11	0.70	-5.49	102	250	2009-01-15 18:05:59	2004-03-10 16:19:24	6	2	43	0	119	277	568	302.40	23	67.78	CHANGED	Rhlhlhhs.Glh..........stpa..hPp.........psGt..................sa............phsts..LpPLp...sh+cchsllsGlsp.tst......suHtsss.saLou.....h...tstst...hpss.lSlDQlhAppl....Gp..pTRasSLplusps..............tt.hss.slSas................psGp.....Plss..psPpplFc+LF.usssss........tttppp..hppcpSlLDtlhpcu+sl...pppLupsD..+pKLDpYhsolR-l..Epcl..........pptpthh........sh..t..Pthsht.s.................ss.shhpch.chhhDLhslAhpsD.TRVsThhhsss.........hhht.........tl.Gl..............stshH.slSHp...sss.ptht...phtphcpahspphuh	..................................................................RhshhhhstGsh.....................ppa...hPp...............ssGp...............................sh.............p.hsth...LpPLp...sh+schsllsGlsp.tst.............ssHtsss.shLTu......s...tsss...........thpsu.hSlDQhlAppl......up....pTphs.SLplusps..............st..hts.slSas................sssp.....Plss..psPpthFc+LF.usssss.............tttppp.............hppcpSlLDhVtp-scpL...pppLupsD..+pKLDpYhsulR-lEp+l.............pptptht.......st...h......Pphsht.s.......................tstshhpch.+lhhDlhslAhpsDhTRVsThh..huss................tth.hhs..............tl..Gl................................spsaH.slSHc........sss..ptht......phtplspahhpthu.............................	1	102	108	114
+7415	PF07587	PSD1	DUF1553; 	Protein of unknown function (DUF1553)	Studholme DJ	anon	Blast clustering of Pirellula genome	Family	A family of proteins found in Rhodopirellula baltica.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.68	0.70	-4.99	41	593	2009-01-15 18:05:59	2004-03-10 16:47:29	6	37	66	0	253	700	966	244.70	30	28.00	CHANGED	ssRhsLApWlsss-N...PLTARVhVNRlWpphFGp........Gl.Vcos-DFGhtGssPoHPELLDaLAtcFl-.sG.....WslKpLhRpIlhScTYppuSpss......scs........th.D....PsNchhuRhsh+RLsAEhlRDshLsloG...Ls.p.htGssh....s...........t........h.ts.stpphRRulYthhpRsh..............sshhpsFDtsststssspRppossP.hQALsLhNsshhhptup....thApplhpp............................................................................................tsss........ppplsthFttshuRtPospEhpthtshlsp	...................................................................................................t.pRhtLAcW.ls.ssc.N...PLs.ARVhVNRlWpphFGp........Gl.Vpos-DF.....Gh.....G......p.........P.o..H..PELLDaLAscFhc..ps............WslKpLhRhIlhSpsYppoSpss.......spt........................th..D....spN....phhuRhshpRLsA...E.lRDshLssoG.....Ls..p..ht..G.s.h...ts..............................................tt..h.RRul..Y....th...hpRsh....................sshhtsFDtss.t.p..s.s.spRpp.osss.hQALhlhNss.hhhctup....thup.p..hhpp..............................................................................................................................................................................................tt...........pp..tlpthahhshuRtPsspEhphhhphh..p.......................................................................................................	0	217	249	252
+7416	PF07588	DUF1554		Protein of unknown function (DUF1554)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of proteins identified in Leptospira interrogans. 	21.20	21.20	22.00	31.10	21.00	18.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.20	0.71	-4.71	15	119	2009-01-15 18:05:59	2004-03-10 16:55:52	6	6	18	0	20	123	4	148.20	36	48.04	CHANGED	sssssHNG..NaGGIoGADAaCp..uplPo.sLsusG..sYKAMLVD.s.....ssRhATossPNSosG..QhDWVhpPNppYpRuDsss.h.lhTTNusGlFsFs....LpNuFss....shpsshWTGLs.......ssWpThs........stsCss....Wso...................us.sshhGtaGsusp.psust	....................s..s.hHsG..shGGIuGADuaCp..uphPu...slsusG..sYKAMLVD.u.....ss..RhAsosssNussG....QhDWVhpPNppYpRu-.sss..h.lhTTNusGlFsFs......LpNsFss........hputhWTGLs.......ssWTThs........s.sCss..........Wss...................us.hshhGhhG.usthpsth....................................	1	13	18	18
+7417	PF07589	VPEP	DUF1555;	PEP-CTERM motif	Studholme DJ, Bateman A	anon	Blast clustering of Pirellula genome	Motif	This motif has been identified in a wide range of bacteria at their C-terminus.  It has been suggested that this is a protein sorting signal. Based on phylogenetic profiling it has been suggested that the EpsH family of proteins mediate this function [1].	20.70	18.00	20.70	18.50	20.60	17.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.59	0.73	-7.37	0.73	-3.88	163	1616	2009-09-11 20:23:54	2004-03-10 17:07:42	6	71	212	0	766	1794	370	25.50	40	9.66	CHANGED	sVPEPuo..hsLhulG..lhulsh.....hpR+	...sVPEPuo..huLluhG...Lsuluh.....htRR+........	1	297	677	745
+7418	PF07590	DUF1556		Protein of unknown function (DUF1556)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	\N	25.00	25.00	31.10	115.10	20.70	17.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.32	0.72	-3.75	3	3	2009-01-15 18:05:59	2004-03-10 17:11:44	6	1	1	0	3	3	0	93.70	37	69.21	CHANGED	MNQGSETTERIRTSSEGRMGAICRDGNLKLKTHRAhSVNPLPsNSSPupVV+SKRPtssSsAScPTtLpVRERsR....GulPpucFtpuoShpPtss	MNQGSETTERIRTSSEGRMGAICRDGNLKLKTHRAhSVNPLPsNSSPupVV+SKRPtssSsAScPTtLpVRERsR....GulPpucFtpuoShpPts..	0	3	3	3
+7419	PF07591	PT-HINT	DUF1557;	Pretoxin HINT domain	Studholme D, Zhang D, Iyer LM, Aravind, L	anon	Blast clustering of Leptospira proteome.	Family	A member of the HINT superfamily of proteases that is usually found N-terminal to the toxin module in polymorphic toxin systems. The  domain is predicted to function in releasing the toxin domain by  autoproteolysis [1].	25.60	25.60	25.60	25.60	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.62	0.71	-4.27	4	642	2012-10-03 10:25:13	2004-03-10 17:20:07	6	125	235	2	152	664	82	116.00	33	14.87	CHANGED	LVpTssGhpAIs+IpsGD+Vlups.pohcsuYKsVptpYsp.hpEhlalplsD.....psLlosc.HPFYsp.stalcApcLphGDcLlspsGshpsVpsIhlc..scPhKsYNlpVsDaHTYFVt.....TpGlWVHNu	...............................................tG.h.h.s.Itplps.G.D.Vhu..ts..t..o....sp...h.t....+.V..ht...h.a...s....p.........p.c...h...l.......l..pl.s.s..............................psl....h.s.st.HP......Fa.....s..p....................................t................t...W..........lpA..........t.cLp.sGsp..L........h.......s.p.s.......G............p..h..........s.V.p.s..h.th...c..............s..p..s.hpsYNLsVs.chHTYa..Vt.....sp...u....V..hV..HNt.............................	0	72	126	136
+7420	PF07592	DDE_Tnp_ISAZ013	Transposase_36;	Rhodopirellula transposase DDE domain	Studholme D	anon	Blast clustering of Pirellula proteome	Domain	These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.	22.50	22.50	22.50	23.80	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.82	0.70	-5.68	11	318	2012-10-03 01:22:09	2004-03-10 17:32:17	6	4	69	0	66	395	81	192.00	30	76.56	CHANGED	lpcLcuLl-ssTtGDPp..SsL+WTpKSspplucpL.pppGap....lutpsVucLLp.chGYSLQustKTppGspHPDR-sQFchINcplpphpssspPV.ISVDTKKKEllGsa+NsG+pWpppups.cVtsHDF.s.shGcssPYGlYDlssNpGaVsVGss+DTu-FAV-Sl+pWWpphG+c+YPcApcLlIsADsGGSNG.RsRhWKhcL.QcLusphGLsIpVCHaPPGsSKWNKIEHRhFSaISpNW+GpPLsoaEsllNLIuuTTTppGLpVpspLDcptYpsGlKVoDcphcslp..IpRsshHs-WNYpIpPp	........................................................................................................h.....................................................................................................................h..pht..lG...p.G..h............p................uhh......t......hs.s..s...s.hhsttlt.hW.......h.t.ppl.l.hDsG.spNs.h.p.ah.th..t.hutp.th.lplhahPPhpSKaN.lE.+has.lp.p.WpGp.L..shpshlth..tT..hT..pGlt..stl.pt.Y.hGhpl..sp..p..thtth.....h.ht..h.tWsh.l..........................	0	10	46	63
+7421	PF07593	UnbV_ASPIC		ASPIC and UnbV	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	This conserved sequence is found associated with Pfam:PF00515 in several paralogous proteins in Rhodopirellula baltica.  It is also found associated with Pfam:PF01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC Swiss:Q9NQ78) and in several other bacterial proteins (e.g. Swiss:Q84HN1 [1]).	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.31	0.72	-4.30	79	553	2009-01-15 18:05:59	2004-03-10 17:57:57	7	89	240	0	278	593	823	70.90	27	9.06	CHANGED	sAlGApVplp.ss...uppphppls....uGuGahu.psshpl+FGLGs..sssssplplpW..P.sGphpphpsl.s....sspphhll	...................AlGAcVpl...h..ss............uttp....hppls....sus.G.ahu.ps.pshlHFGLGp....sspssplclpW..P..sGp...h.pp..hpth..t.....ssphh...h..................	0	144	226	255
+7423	PF07595	Planc_extracel		Planctomycete extracellular	Studholme DJ	anon	Blast clustering of Pirellula proteome	Motif	This motif is conserved as the N terminus of several Rhodopirellula baltica proteins predicted to be extracellular.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.94	0.73	-7.26	0.73	-4.01	27	37	2009-09-16 17:53:18	2004-03-11 10:45:04	7	22	4	0	24	38	0	24.90	37	1.14	CHANGED	ppppppppsp+RRLthEsLEsRpLL	...pppppppsp+RRLthEsLEsRpLL	0	24	24	24
+7424	PF07596	SBP_bac_10	DUF1559; 	Protein of unknown function (DUF1559)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A large family of paralogous proteins apparently unique to planctomycetes.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.77	0.70	-4.37	147	1532	2009-01-15 18:05:59	2004-03-11 10:51:16	6	21	22	0	391	1685	425	209.30	20	68.30	CHANGED	QQAREAARRhpCsNNLKQlGLAlHNYH..DTatt.h...Psushssssssst.........................hs..........Wts...h..lLPalEQssl.a-ph....................shstshtsssssssstt................................ls...........sa......h.C.PScs............................................t.....ssssttsstsssssssstsssstsstssssGhhhhss..................thphpDl..pDGsSN.TlhluEpththsstststhh......................................................................sthststttssshshssssshsssssssssssttshsShHsG.Gsphh...huDGSV+F..lo-sl-hs	...............................................................................tAREAAR.RspCtNNLKQlGLA.hpsY.p...s.s.h.s.t....h.......P.sst.hss..sss.s....................................................................hs.......ahh.............lhP.a.h....-..pt.s.h..hp.t...h....................................p...t................................................................h.hh..C..Pop............................................................................................................................................................................................................................................t.t.th...DG.sp..shhh.E.........................................................................................................................................................................................................................t.p....t............-ut...........s.....................................................................................................................................................................................	0	391	391	391
+7425	PF07597	DUF1560		Protein of unknown function (DUF1560)	Studholme DJ	anon	Blast clustering of Pirellula genome	Family	Small family of short hypothetical proteins in Rhodopirellula baltica.	25.00	25.00	25.90	37.10	20.40	17.60	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.34	0.72	-3.96	2	4	2009-01-15 18:05:59	2004-03-11 11:09:06	6	1	2	0	3	4	0	38.50	75	69.06	CHANGED	C..shGhL+Ps.hs.Ro................ISVRSAcISVPLAALAEH	CVGNTGVLKPNIhsP+o................ISVRSAEISVPLAALAEH	0	3	3	3
+7426	PF07598	DUF1561		Protein of unknown function (DUF1561)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of paralogous proteins in Leptospira interrogans.	25.00	25.00	385.70	385.50	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.19	0.70	-6.57	23	62	2009-01-15 18:05:59	2004-03-11 11:15:06	6	1	10	0	31	64	0	608.70	54	98.82	CHANGED	Kl....Ll..hhhSlhl.....s.pTshsA.....lsspllQKPsDpP+DKsI+V.pVHsGtcYCYuPsFosGEuYIhIppCsp.pVhpARYDVFQRIuaNINsTWLChTAPpoVs....cuppsWDYlhLRPCsINDP.QRWIIK.....cNuFaTADt+aRlKDhsWYuYISKNuuDhYsHTLs.soMscWlpTlATPGNISl+T.IAWsh.os.G........ppYaIpssGSsp.ssTP..LYYNPENGHlAQY.PsSGslhCMhSp.ssspsWNWVpWthC..oD.....sl....SKcssuaWNl.hhssctGhIh.DYpGNhLRVT+YGosWGVsYTAKPsYLcpDTo..NSPTShFllspDl.cWsRYssuNLGcT.pYCPA.GpKcsls.....+pRlKR..oLPPDFpLT-pWl+RLa-IApSoo.....ssupppl.GhCGsChLpohQMLAELQEaHspsPLQsG.GYFFsTA.spDPFISFRQRaPtLsphLpss.shas.....ss.p.hspsppluhuuAhshLPQY-Wps.SshhpTcsEhhSclpsLlsuPsGolWhsllhcppsDG.shsGHA.PILRTspGLVlIPTNs.sshoL-paRpuLsPT....pDPppllsphhptus.psLt..sLsThQ.hstlhcsPhshhlSpRNCTGEG-cRRGoGchPpoohlNQCu...S....GRCu	.....h.hhhlhhl.lhh.......s..s.lsh....tls.pllQKPTD.P+DKsI+l.hlHsGupaCYuPsFosGESYIhI-pChp.pVhsARYDVFQRISYNINNTWLCITAPEoVl....+ucpsWDYVpLRPCTINDPLQRWIlK.....-NuFWTADt+YRLKDhsWYuYIS+NSGDpYsHTLs.sSMscWlpTlATPGNISIpTSIAWshto..u........pRYFI+ssGSsK.NTTP..LYYNPEsGHlAQYsPhSGsLhCMYSph.ss.pWNWVpWthC......oDt..sl.SKcN...PuFWNV..hts-cGGhIh.DYpGNhLRVTRYGsNWGVAYssKPsYlcpDTs..pSPTSLFllc+sLLcWsRYTsuNLGKT-QYCP.A.GpKEshh.....ppRlKR...oLPPDFQLTE-Wl+RLY-IApSss.....sssp.pph.GlCGlChLpoFQMLAELQEYHSpsPLQuG.GYFFDTAPspDPFISFRQRYPpLsphLpslsphas.........hspsphlshuoAhsMLPQYpWps.SsphsTRsEhhSHIpSLIsSPsGSlWLulhtppcsDG...ohsGHAlPILRTSQGLVVIsTNs.sshoL-pYRpsLsPT....pDPpplIss.hcpsspsL.t..pLsTlQ.LsphYpNsFDhhlSsRNCTGEG-DRRGoGpYPsSo.lNQCu..u....GRCs....	0	12	14	28
+7427	PF07599	DUF1563		Protein of unknown function (DUF1563)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A small family of short hypothetical proteins in Leptospira interrogans.	20.40	20.40	22.00	20.80	20.30	17.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.07	0.72	-4.08	2	16	2009-01-15 18:05:59	2004-03-11 13:20:55	6	2	6	0	7	10	1	36.70	74	15.61	CHANGED	MNIILIsFFLLETLENLYsTYVEh.LKQhFLDphQKI.KssRK	..MNIILIGFFLLETLENLYuTYVEh.LKQhFLDphQKI.KhspK..........	0	4	4	5
+7428	PF07600	DUF1564		Protein of unknown function (DUF1564)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of paralogous proteins in Leptospira interrogans. Several (e.g. Swiss:Q8F4V2) have been annotated as possible CopG-like transcriptional regulators (see Pfam:PF01402).	25.00	25.00	36.10	35.10	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.99	0.71	-4.92	14	111	2009-01-15 18:05:59	2004-03-11 13:28:11	6	1	7	0	32	122	0	159.80	35	92.35	CHANGED	McllhLsospclpSth.......tcppssssoLLIPcshh.pLscp..cpKsLppcls.LLK+YsKhlhopchltpcssKshYQps.h..cLK+hshRssstsWshLGlLAtsHGVSRChLFshLLhL-...shscSIspshstGsPsFpts...aphhhclshtpNplo+clpht.ps....hhh.l	.....................MthlhhssspclpSsh........cstsussoLLlPcshap+hstp......c+KsLpp+LPhLL++YsKhlsSh..cRLpp.+.As........KhpYpcssG.....chK+holRVpousWupLGsLAsAHGVSRCYLFNYLLhL-...t.ts.hlpThstGVPsFHhs...Yphh.hclshppN.loRcLphcPpsh...h............................................	0	24	24	24
+7430	PF07602	DUF1565		Protein of unknown function (DUF1565)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	These proteins share a region of homology in their N termini, and are found in several phylogenetically diverse bacteria and in the archaeon Methanosarcina acetivorans. Some of these proteins also contain characterised domains such as Pfam:PF00395 (e.g. Swiss:Q8YWJ6) and Pfam:PF03422 (e.g. Swiss:Q9FBS2).	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.92	0.70	-5.23	8	240	2012-10-02 14:50:22	2004-03-11 14:07:11	6	32	169	0	75	498	272	161.50	28	24.64	CHANGED	lsGND.sssGo.cusPa+TIT+Alhhu+uss..lIplAPGsYssuoGEpFPlhlP-GVsLhGDEsuKGh....tslhhs.sh.hs+su..hIpGuu....sDls....hp.sTIlssNposIAGhsITNP....................s.....h+usulalpus.uspI+NNThou.shtcG..........Ips.........ssat.ssusuG.....Nl.......IoGNp......lt...........sphs.....GIuIsstpsu..h.....sKl.EN................N...lIsp.........Nth......G...Vs.sslu.hDLGsuSpsosGsNphSsNucpD.Iph..sspsspsL...hAhNNphD+.PPTl	.......................................................................tGsD.sssGo.pp....sPa..+T..I..spAl.p.h.A.tsGs.......slhl.tsGs.Y..st......p......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.t...................................................................................................................................................	0	39	58	69
+7431	PF07603	DUF1566		Protein of unknown function (DUF1566)	Studholme DJ	anon	Blast clustering of the Leptospira proteome	Family	These proteins of unknown function are found in Leptospira interrogans and in several gamma proteobacteria.	27.50	27.50	27.50	27.50	27.40	27.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.15	0.71	-4.39	70	852	2009-01-15 18:05:59	2004-03-11 17:18:20	6	68	343	0	265	776	364	132.00	20	39.54	CHANGED	sss.VpDppTGLhWp+Cs.G.th................tGsstthsWpsA.....lshs......sslsts...............shss.WRLPslcELtSl.....l....-hssh....sP.......ls..........spsFss......s............sshaWoSTs........tssst.....t..uWs.....lsass...Gtshh.......spssthhshhVRs	.............................................................s....lhD.hTsLhW...t..p.................................................tspsthh.sa.ppA........................hphs............pshsts..........................................GhssW..R......LPshp.......ELt.sL.......h..................chspt.......tst.................hs..............................sshFss.........s.....................sshaWou....os.........pstst.................t...uah...hsh.s........Gth..........thttt..hhh.l..s....................................................................................	0	112	193	238
+7434	PF07606	DUF1569		Protein of unknown function (DUF1569)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of hypothetical proteins identified in Rhodopirellula baltica.	20.80	20.80	20.80	21.00	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.79	0.71	-4.30	13	113	2012-10-02 14:44:17	2004-03-15 11:23:25	6	3	83	0	55	261	38	144.50	23	82.67	CHANGED	hsphtpLpassLpsAls-lppLppsuhpps..GsWsLuQlhpHLAtuh-hSl-GaPthhstlFt..+slh+hhahshht+GcMp...sLctshPuuh..ssslD-stslc+Ltpolp+FpsasGchsPH..AaGpLs+spachhHshHhtpHLpFlpPp	.......................................................................................thh............pphhsclp.pLp...p.s..ph......Gch...sluQhltHs.......s...ts.h...c........h....u...h....p.....s....h..s.h........t..s....h.ht.............phl..h.+..h.h..h..p........hh.h...p...sc..........pp..st..s..ts.s.t..h.....h..h....ss.....s....h.....-....h....c..p...p....h..p.cL..hp..t....lp...pa..p.......p...t....p.........s...s...h........t.........s........H...shFGcLopccWsphthpHlsHHLpQF...s....	0	30	48	53
+7435	PF07607	DUF1570		Protein of unknown function (DUF1570)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of hypothetical proteins in Rhodopirellula baltica. This family carries a highly conserved HExxH sequence motif characteristic of members of the Peptidase clan MA.	21.70	21.70	21.70	22.10	21.60	20.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.75	0.71	-4.14	9	34	2012-10-03 04:41:15	2004-03-15 11:53:20	6	4	13	0	18	107	21	125.70	27	27.92	CHANGED	slATlsHEAsHQlAaNsGlpsRhuc.PhWloEGLApaFEsschtsttuW+GlG.tlNphRlpp.acchhs.ccsuss.t...chIssDptFptsps...s.sAYupAWAlsaaLhcpchccaspalpplut+hPhp	....................................tTlhHEusHQl.saNhGltpRh..u.s....h.P..hWlsEGlApaFEsssh..p....tsth.pu..lG..tlNph+l....tt.h...c....phhs.tp..s...stsht............phl.hs.D.p..t.......F.ttspt.....stsu..YA..p..u..WuLsaaLh..p....p....c.......p..c...a.scaLppluph.sh......................................	0	16	17	17
+7436	PF07608	DUF1571		Protein of unknown function (DUF1571)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of paralogous proteins in Rhodopirellula baltica.	25.70	25.70	25.90	25.70	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.03	0.70	-5.21	4	69	2009-01-15 18:05:59	2004-03-15 11:58:36	6	1	57	0	23	72	16	195.40	40	60.37	CHANGED	hlK+Ep.lsGpLpEsphMslKlRs+.psttt.spPhSVYLpa.sPcohKGREVlYlEspN-GphlV+cGGhtGphl.Tlpl-PpGhLAMctpRYPIT-lGlcslhp+LIEhtc+Dl-ps....sscsshhcst+hcG+ssThlQl..spPo+css.sF+pAplaID-EhclPIphcuasWPs........sEs-pspLIEpYsYtDLplNsuLsss-FDsTN.cYpFc	.......................hlRQER.IuGch.u.s.P-pMhlKlp+p.........PLRVYAKWLPsGA+uGQElIYDsocRsDEMYGHLGGlLG+ls...hhhssDGsLARAQSNHpV+DLGsEalsshaLsEu+K....h..hEAG....sh+sTplEu+Tl.cGlRVlALTa..EoPsG+PQhhhpKcplh..lD.hc..sh.h..plEuY............................ss-.GclhE+lVa-cIs.p.s.L--osFDPcNPDY+F........................................................................	0	13	14	17
+7437	PF07609	DUF1572		Protein of unknown function (DUF1572)	Studholme D	anon	Blast search with Q7UW06	Motif	These proteins, from several diverse bacteria, share a short conserved sequence towards their N termini.	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.15	0.71	-4.69	15	202	2012-10-02 14:44:17	2004-03-15 12:06:42	6	1	177	0	65	278	44	157.90	45	91.07	CHANGED	shup..sYLpsspppFcshKphG-+uluQLo-EpLphshs--sNSIAlIVKHluGNMhSRWTDFLT.....oDGEKssRNRDuEF-sshpo+pEllttW-cGWphlFsALssLss-DLpcTlhIRGEuHoVhpAIpRQlAHYuYHlGQlValuKhl+uscWpoLSIP+Gc	..........................................................................s..sppYlpsshppFcthKp.GE+sLuQLo....E.p.lpW.s.s.p.E.-.oNSIAlIlKHL...p...G...N...M...p...S...RW.T.D.F.L...T.........oD..G..E..K..h..s.R.N.R.....D...u...E.F-.s..s.h.p.o...K....c....E...l.....LtsWpc...GWp....hlF.ps..h.ss.Lss-cLh....p...s..V..h..I.....R....G.E....u.H....TV..h..p....A..IpRQ.....lu..HYuhHlGQIlYluKhLKps-WcsLSIP+Gp.......................................	2	30	53	61
+7438	PF07610	DUF1573		Protein of unknown function (DUF1573)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These hypothetical proteins, from bacteria such as Rhodopirellula baltica, Bacteroides thetaiotaomicron, and Porphyromonas gingivalis, share a region of conserved sequence towards their N-termini.	20.50	20.50	20.70	20.90	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-7.98	0.72	-4.38	99	698	2009-09-13 15:23:25	2004-03-15 12:54:42	6	12	236	0	193	676	292	45.00	38	20.45	CHANGED	sF.phpNsGcsPLlI..splpuSCGCTssphs+.cs......ItPGcp.uplpVpa	.....FphpNsGctPLlI..splpsSCGCTss.p.as..+.cP.....................ltPGcp.uplplsa...............	0	105	174	193
+7439	PF07611	DUF1574		Protein of unknown function (DUF1574)	Studholme DJ	anon	[1]	Family	A family of hypothetical proteins in Leptospira interrogans.	25.00	25.00	25.00	26.60	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.13	0.70	-5.58	4	48	2009-01-15 18:05:59	2004-03-15 12:59:46	6	2	10	0	17	40	4	313.40	24	92.76	CHANGED	Mh+KhaLhhPlLhFlhsFslDKlho.phhcsYhptuhshlaYchKcpLhpcLl.....c.pppsc-pKKlhlhFGsSRhh.FpssslcpK.hsDWhlYNFSuPsusPsYaLYaLE+lhssGlKPDhllh-.sP..Fsssoshhhc.sLtYuhDs.FlL+YhsphShpDhstahhs+LFtssh.pPchp.hhtRhK-tsh..h..uh.pshhltNLKpscusAhosu.s.V...spss-+LcccAh+hhs.hhssashushQhtFhtphLplsccpsl+shhlhPplhcshcchhpphch..........hc.WhsIlcpltEppuss.hsMsc.c..htCppa.DstHhSssCYpsahcFIlc+lsh	...................................................................................hpp.hlhhPhllhhhhFhlDKlhhlthlcs..hh.p..tths.hhYc.+.cplhpcLh..................cpp..tp..ttcp+KlhlhhGsSRsh.F............st.phl...c......cp..hs-....a.lYNFSsPsusPsYahYah..E+lhp.sGl.+PDhllh-hsP..Fspssshhhc.sLthuhs..Flhpahs................huhpc..........hphahhp+lFtsth.pPphp.hhtRh...p...stt...h.........th..pphhh.....sLpptct......sthssh......................ps.-p.Lp..ppu.p.h...hp.hhssaphu.hphtFhcphlphhccpsltshlhhPtl..shpchhcphph............hc.W.hshhppl.t...cph.shs.....hlshsp.c.th..pCptasDsuHhSssCa.t.hchlh.ph..h...........	0	5	13	13
+7441	PF07613	DUF1576		Protein of unknown function (DUF1576)	Yeats C	anon	Yeats C	Family	This small family is found in several undescribed proteins. The alignment is distinguished by the frequent occurrence of conserved glycine and aromatic residues.	25.00	25.00	34.30	26.70	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.25	0.71	-4.76	17	337	2009-01-15 18:05:59	2004-03-15 14:44:55	6	3	162	0	52	279	0	176.20	35	82.51	CHANGED	hlh.u...spp.hpGhhpIhppsuhLlTDahtlsGhGuoalNhGlLsll.hhhlhlhpsplNGPsluulhTlsGFuhFGKplhNlhPlllGlhlhulhpp.pshss..hllsuLFGTsLAPlsuph..............G.lhGIlsGFlh.slstshuhlHtGhNLYNsGFouGhlAhhlhsllcsa	.......................h.........pphhpGhhpIlpssuhLhTDahthsGhGushlNhGllsllshhhlhh.h.tsplNGPsluulholsGFShFGKplhNhhPIllGlhLhuhh...pp...pshsp..hllsuLFGTuLAPlsu.h..................GhhhGllhGalhsslstphthhHtGhNLYNsGFouGllAhhllsllc..........	0	34	48	52
+7442	PF07614	DUF1577		Protein of unknown function (DUF1577)	Studholme DJ	anon	Blast clustering of Leptospira proteome	Family	A family of hypothetical proteins in Leptospira interrogans.	25.00	25.00	56.60	56.00	22.00	21.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.60	0.70	-5.48	6	39	2009-01-15 18:05:59	2004-03-15 15:06:33	6	2	9	0	14	43	0	259.80	29	66.28	CHANGED	p+cHlIpKYLlpp-LhhKhss.ccchs.IhcllE-GpKIlhtsus.psls.sscllLYcILAKYlpLECsllcKh-sslhhlpVscluIA+ppRsssRhsV..-shalTNVloSKTl......I-ANhFsIP....T.VKVsFpDacs+LKpcp.shlplDl....FtsslscKFElV...............KKTcKhLaIcNTp..........DppSYtu.ss.shIchccEl..---lcspl+cYKcpcIh....SELIlPIlYlNcpcppI.PlGYlhlpo+Ep...slopppl.clppL	..............................................phh+lltcaLhtppl.hchs.ptpphh.lhchhc-uphIlh.s.pt.pshs.psclsLa+lLu+alpl-spllc.chcsplhhhplscltIApppRpssRlsl..s.shahsNllssKol......Ists.hsIs....TtV.cVpFpDhcp+lKpch.shhhIsl....atstlsccaElV...................K+ocKhlaIpsTs..........sppSYss.sppshlchtcEl..--tlcphhpca+spKI+....S.LIhPIlYhsctcptI.PlGYlhlpocpp...pIstppl..ltpL.......	0	5	9	9
+7443	PF07615	Ykof		YKOF-related Family	Yeats C	anon	Yeats C	Family	\N	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.68	0.72	-3.82	13	198	2012-10-01 20:40:01	2004-03-15 15:41:33	6	4	133	16	68	262	49	78.90	25	77.88	CHANGED	.uusQFSLYPM.ssDal-hIhusl-hhc..puslhscocchuTpLsGcstslFssLcslFhpsupsssHlslssTlStssPuc	....................ssphSLYPh.........s........s.....c...a.h.s.h.Ih.sslctlc......psslhhp.oss.huTtlpGchppVasslpshattutp.p....HhshphshShtsPs........................	0	21	47	56
+7445	PF07617	DUF1579		Protein of unknown function (DUF1579)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Sinorhizobium meliloti and Agrobacterium tumefaciens.	20.70	20.70	20.80	21.90	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.95	0.71	-4.58	17	94	2009-01-15 18:05:59	2004-03-16 15:14:49	6	1	86	0	51	110	25	150.90	25	89.46	CHANGED	hs.cPppEHpWLpcllGpWsh-s....-s.MsP-pPspcspuhppVRp.lGGhWl.s-upGcMs.....t.GsshsolhTLGYDss+pcaVGTWlGSMMothWlYcGpLDpss+sLsLpuEGPshss.....sG+hupYRDVlphhDsscRshoSthhsp-GpWhphMsupY+Rp..c	...............h..psttpHphLppl...lGcWssps....chhh...sPsps.......st.psp.hptss+..l.sG.hallp-sp......Gphs........Gps..hpslhslGYDstppcaluoWlsS..Mhst..hhhhcGp..hsts.sp.slsLpspsssht.......sG.h.hpa+chhphh.sssphshp..h.t..t..sGphhphhphpapR..h..................................................................	0	23	32	41
+7446	PF07618	DUF1580		Protein of unknown function (DUF1580)	Studholme DJ	anon	Blast clustering of Pirelllula proteome	Family	A family of short hypothetical proteins found in Rhodopirellula baltica.	22.90	22.90	23.60	24.70	22.30	22.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.48	0.72	-4.60	5	10	2009-01-15 18:05:59	2004-03-16 15:20:36	6	1	3	0	6	14	0	53.60	34	55.43	CHANGED	PLLcAlcLEoGhRPusSTlhRWuh+PNRHGNhLcoWhlGGR.RhTSVpAV+RYlcAsT	.........shhphhc.psG.RsHsSTshRWsh+ss+pGshLcohhlGGR.RhTSVpAVpRalcsss...	0	6	6	6
+7447	PF07619	DUF1581		Protein of unknown function (DUF1581)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	Several Rhodopirellula baltica proteins share this probable domain. Most of these proteins are predicted to be secreted or membrane-associated.	20.50	20.50	21.00	29.10	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.89	0.72	-4.00	7	15	2009-01-15 18:05:59	2004-03-16 15:26:38	6	4	2	0	8	16	0	83.90	35	7.17	CHANGED	Rssl+Dspppshl..NGR.lppcslhssusPWlulRu.hpsputhRNL+IsGsPplPsplshlsutpLhGW.ssYasts....tsp.tGph	..Rssl+Dspspshl..NGR.lpp-sltssusPWlulRuphpsputhRNL+ITGsPpIPcplshlsuspLpGW.ssYasts....tsc..sp.........	0	8	8	8
+7448	PF07620	SLEI_Leptospira		SLEI	Studholme DJ	anon	Blast clustering of Leptospira proteome	Motif	This highly conserved sequence motif is found at the C terminus of several short hypothetical proteins in Leptospira spp and related organisms.	16.20	16.20	16.50	17.80	16.10	16.10	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.85	0.74	-6.21	0.74	-3.76	10	31	2009-01-15 18:05:59	2004-03-16 15:31:40	6	4	30	0	4	38	0	15.30	65	4.13	CHANGED	stphLRDNSLEISNph	I.IMEE.GNSLEISRQM...	2	2	2	3
+7449	PF07621	DUF1582		Protein of unknown function (DUF1582)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of hypothetical proteins in Rhodopirellula baltica.	25.00	25.00	26.60	40.60	23.80	18.90	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.84	0.73	-7.06	0.73	-3.70	5	9	2009-09-11 06:28:21	2004-03-16 15:42:10	6	2	1	0	9	9	0	28.90	38	19.74	CHANGED	RuLPSPcsLs-pRlscsssCsscG.tsLA	..RsLPSPc..hstRlss.ssCspcG.hsLu.	0	9	9	9
+7450	PF07622	DUF1583		Protein of unknown function (DUF1583)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	Most of these Rhodopirellula baltica hypothetical proteins also match Pfam:PF07619.	22.80	22.80	22.80	35.40	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.24	0.70	-6.01	6	21	2009-01-15 18:05:59	2004-03-16 15:48:41	6	5	2	0	11	21	4	306.00	25	36.07	CHANGED	tltGSphESLLpYhRPlh-sspIEYEFFYDsGpsusHPAlsRhAhLIcs-GVu.H.hTDGtappo.LRPDNthhh.p.tpcpuslPL+sspWN+scLphtG-clpLpLNGpsIaEpsl-sps.sRsFGLFHFuDpopl+VRsLpLSGDWPppL..hspQpLAsshsscLctssscLspsFpHDFcc.shsschF.tpst..scshhss--Gl+hstuo.usacphshsPphplcGDFDlTAcFsthQsss.Ess.huulthplsL-sstpcpl...tsspthscppGp+lhsshphphssGpt.ppthst+psp-uTSG+LRlsRRG-plaaLFApsDSspF+LltpEpsscuslssuGIpL.sslssssGosSupWsslolRAEcl...ssusPDhpssLu..plc.s+st	...............tLL.YhRPhhcttplpYpFaat.spstsaPslsRhshhlp.sGht.p.hp.s...t.s.h.ssNh.h......t.sshs.psptWNphcl.h.sspl.lpLNtp.lhpt.lps.t.s.pFGLa+.tcppthhhpshhhpGcWPttl.....p.hs....tpLttthptLspsapaDFpc.t.sschF.thst..stsh.ts-cGlphptsu.s.apthsls.phtlcGDFDlshpFs.hph.s.tss...stlthplphssstpspl....hhhthsttts.phhtthphthssGp..phhhshthp.s.usushLRlsRRG-plahLhuptssp.hplltppphsptsl..hslph.h.h.s.stsspsss.hhpplpl+Acpl........................s..........	0	11	11	11
+7451	PF07623	PEGSRP	DUF1584; 	Protein of unknown function (DUF1584)	Studholme D	anon	Blast clustering of Pirellula proteome	Motif	This sequence motif is highly conserved in several short hypothetical proteins in Rhodopirellula baltica. It also is associated with Pfam:PF07621 in Swiss:Q7UJJ9.	25.00	25.00	29.60	28.80	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.91	0.72	-7.04	0.72	-4.64	6	15	2009-01-15 18:05:59	2004-03-16 15:59:05	6	2	2	0	14	15	0	26.50	76	24.92	CHANGED	LAVhRKPPGEEPEGSRPSATSLVVHVV	.LAVhRKPPGccPEGSRPSATSLVVHVV	0	14	14	14
+7452	PF07624	PSD2	DUF1585; 	Protein of unknown function (DUF1585)	Studholme DJ	anon	Blast clustering of Pirellula proteome 	Family	A conserved sequence region at the C terminus of several cytochrome-like proteins in Rhodopirellula baltica.	21.40	21.40	21.40	21.70	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.26	0.72	-4.32	63	199	2009-01-15 18:05:59	2004-03-16 16:05:40	6	17	35	0	86	222	297	75.30	25	9.62	CHANGED	ssGppFpshtpl+phLhpc.p-pFscslsc+LlsYALGRslphsDcstl-pIhsphcpssaphpsllptlVpSc.Fp	................sGppFssht-L+phLhpp.tcphscshsc+llsYAlGRslp.htDcstlcplhpphppssaphpsLltslVpSp.Fp....	0	79	80	83
+7453	PF07625	DUF1586		Protein of unknown function (DUF1586)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of short hypothetical proteins in Rhodopirellula baltica.	20.80	20.80	21.50	22.30	18.60	19.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.62	0.72	-6.59	0.72	-4.12	3	11	2009-01-15 18:05:59	2004-03-16 16:08:24	6	1	1	0	11	11	0	21.80	73	40.82	CHANGED	SRTALAAVSQTPTGANAcWHLL	SRTALAAVSQTPTGANAaRhll	0	11	11	11
+7454	PF07626	PSD3	DUF1587; 	Protein of unknown function (DUF1587)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07624.	21.10	21.10	21.10	21.40	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.00	0.72	-3.97	66	193	2009-01-15 18:05:59	2004-03-16 16:12:43	6	25	37	0	90	219	315	67.80	31	8.22	CHANGED	RRLs+pEYpNTl+DLLGlc...hshsp....thPsD.ssspGFcNsGpsLthSshphEpYhpsAcphlcpAhhpss	...........RRLs+tEYpNTl+DLlGls....hshsp.............thPsD.ssstG..F-NsussL.s..l.Sshhh-pYhpuAcplhspAhh..s.................	0	78	83	87
+7455	PF07627	PSCyt3	DUF1588; PSC1; 	Protein of unknown function (DUF1588)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07626 and Pfam:PF07624.	21.40	21.40	21.40	21.50	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.39	0.72	-4.16	92	252	2009-01-15 18:05:59	2004-03-16 16:17:41	6	38	43	0	118	280	421	101.80	36	12.41	CHANGED	pRGGlLspuulLshsosuscoSP..lpRGsWlh-plLssssPsPPs.sVs....slpsstsst.........TlR-pl.thH.ppsssCuuCHp.clDPlGauhEsFDslGpaRsppsst	....................RuGlLopuulLshsussscoSP..lpRGhWlhcplLs.pssPPPPs.sVs.......sltsstsss...............ThR-pl..ptH....ppss..sC.u.uCHp.plDPlGauhEsFDslGpaRsp-t.t.....	0	101	107	114
+7456	PF07628	DUF1589		Protein of unknown function (DUF1589)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of short hypothetical proteins in Rhodopirellula baltica.	20.60	20.60	21.50	21.40	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.01	0.71	-4.33	2	15	2009-01-15 18:05:59	2004-03-16 16:24:54	6	1	2	0	13	15	0	82.70	31	79.55	CHANGED	MLWN+AuRPAGHARLSDVRPFT.PGTTWPT.LSQPDASARDTSEFWRSHQRR.GHYLAPSRpFGTKRAVQPVTQsSAMSVHSPRQVQPGLHhCPNPTRQRcTRLNoGEATNVGQVITWHPADALEQStPSSRSRKTQRCPSIHPARYNLsYI.VPTRRVSEtHV	.......................................................................................+..R.sahhtPSRpFtTKRuV.................................................................................................................	0	13	13	13
+7457	PF07629	DUF1590		Protein of unknown function (DUF1590)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These hypothetical proteins in Rhodopirellula baltica have a conserved C terminal region.	25.00	25.00	78.70	78.10	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.51	0.72	-4.35	2	5	2009-09-11 20:23:00	2004-03-16 16:28:30	6	1	1	0	5	5	0	32.00	88	26.02	CHANGED	MtsGAchPPPEISLNAhFPTPPAApAtFSRlh	MENGADCPPPEISLNARFPTPPAARAGFSRRY	0	5	5	5
+7459	PF07631	PSD4	DUF1592; 	Protein of unknown function (DUF1592)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A region of similarity shared by several Rhodopirellula baltica cytochrome-like proteins that are predicted to be secreted. These proteins also match Pfam:PF07627, Pfam:PF07626, and Pfam:PF07624.	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.48	0.71	-3.77	85	245	2009-01-15 18:05:59	2004-03-16 16:52:12	6	37	41	0	113	273	427	126.60	31	15.60	CHANGED	LssaELAoRLSYFLWuShPDpc.LhphAppucL.p...ssphLcpQlcRMLsDs+u..cphspsFssQW.Lshc.plsphs..ctpha.s.pa......ssp.........lcpuhppEshpFhppl.lccs..tslpcLlsuDao.alNppLAca.YGl	...........................................................................................LssaElAoRLSYaLWuShPDcp.LhphAppGc.Lp....sspslptQscRMLs.D.s.+u....cthspsFstQW.Lplc......pls....p...hs....Dtpha..spa................ssp...........................lppshppE...sptah.ppl..lccs..ts.ltcL.lsu-as.alNppLApa.YGl............	0	99	105	110
+7460	PF07632	DUF1593		Protein of unknown function (DUF1593)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of proteins in Rhodopirellula baltica that are predicted to be secreted. Also, a member has been identified in Caulobacter crescentus (Swiss:Q9AAT9). These proteins mat be related to Pfam:PF01156.	42.90	42.90	50.40	43.20	42.80	40.80	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.91	0.70	-5.08	29	158	2009-01-15 18:05:59	2004-03-16 17:00:58	6	7	98	1	97	173	8	254.30	37	53.54	CHANGED	RllVhTD..lts.EPDDtpSLVRhLLYuNch-lEGllsooS....hahpsp..............................spsc.lpc.l...lcAYucVhPNLtpHsss..............YPos-hL+SllphGt.s..................uh.shGpsps.osGSphIlptlpc.s-s..cPLal.sWGGsNsLApALhplcpphstpp.....hpplhsKlRVYsIuDQD.........-s.usWIcppaPc.lhYItu..hpsh.ththssWsshssph..........p.phhopsW..lpppIpp.hGPLGuhYPs........................................hpahs........EGDTPuFLaLlssGLssP-pPsaGuW.GGRa	...............................RlhlhTD..lts...EPDDtpShlRhLlYuNph-lEGlluooS....hahtsp..........................................stsp.lpc.l...lc.uYtclhsNLppHsps..............YP...os-hLpullppGt.s....................................s.htslGpsps.opGSphllptlp...........c..sss..cPLWl.sWGGsNsLAQALhplcpphsstp.....htchhsKlRlYsIuD...QD.........-s.usWIcppaPc.lhaIts...hhshtt..hhhtsWsshssph..............p.phhsppW..lcpsIpt.tGPLGs.t.YPs.........................................h..ta...h.h........EGDTPoFLhLlpN...GLss..s-cPsaGuW.GGRa..........................................	0	34	63	88
+7462	PF07634	RtxA		RtxA repeat	Yeats C	anon	Yeats C	Repeat	This short repeat is found in the RtxA toxin family [1].	20.80	5.00	28.70	5.00	18.20	4.90	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.46	0.74	-6.50	0.74	-3.24	99	3103	2009-01-15 18:05:59	2004-03-16 17:20:41	6	42	64	0	556	2748	47	18.50	35	20.18	CHANGED	utGsuNlls+s......Gsssslsh	.....hhGtuNllT+l.......GsGsslt..........	0	42	271	437
+7463	PF07635	PSCyt1	Cytochrom_C_p; PSC3; 	Planctomycete cytochrome C	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These proteins share a region of homology at their N-terminus that contains the C-{CPWHF}-{CPWR}-C-H-{CFYW} motif typical of cytochromes C, or CxxCH.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.27	0.72	-3.65	141	688	2012-10-03 10:02:11	2004-03-16 17:24:33	6	75	104	0	304	822	1079	58.40	31	7.34	CHANGED	CapCHGscpp..cusLcLDstsshht....sspsG......sullPGcscpS.L.hpplt.spcpshpMPPsc	.ChpCHusspp........cusLcL-shpshhp.....................sspsG........ssllP.Gcs.cpS.L.hpp.lt....sp...s.........s.s..p....MPP...........	0	232	290	300
+7464	PF07636	PSRT		PSRT	Studholme DJ	anon	Blast clustering of Pirellula proteome	Motif	This motif is found at the N terminus of several short hypothetical proteins in Rhodopirellula baltica and the predicted Arylsulfatase B (EC:3.1.6.12) Swiss:Q7UX97.	20.20	20.20	25.50	24.50	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.40	0.72	-4.48	4	7	2009-01-15 18:05:59	2004-03-16 17:31:57	6	2	1	0	7	7	0	30.60	59	19.12	CHANGED	cGNptpaHARPSPSRTPERRRSo.PQTphRER	.......ushhp.HARPsPSRTPERRRSoSPQTphRER	0	7	7	7
+7465	PF07637	PSD5	DUF1595; 	Protein of unknown function (DUF1595)	Studholme DJ	anon	Blast clustering of Pirellula proteome 	Family	A family of proteins in Rhodopirellula baltica, associated with Pfam:PF07635, Pfam:PF07626, Pfam:PF07631, Pfam:PF07627, and Pfam:PF07624.	21.20	21.20	21.20	22.00	20.90	19.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-9.09	0.72	-3.93	81	218	2009-01-15 18:05:59	2004-03-16 17:41:47	6	29	39	0	105	247	304	63.60	29	7.82	CHANGED	tpu+..phlppFup+AaRRPlsss-.lstlhslacpttpp....upsapp.......ulctsltslLsSPpFLY.hsEt	......pucphlppFupRAaRRPlsssE..lpphhslappstpt......stshpp.......ulchslpulLsSPpFLYhsE.....	0	91	97	102
+7466	PF07638	Sigma70_ECF		ECF sigma factor	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	These proteins are probably RNA polymerase sigma factors belonging to the extra-cytoplasmic function (ECF) subfamily [1] and show sequence similarity to Pfam:PF04542 and Pfam:PF04545.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.04	0.71	-4.62	7	258	2012-10-04 14:01:12	2004-03-16 17:52:40	6	7	143	0	120	8136	1123	167.30	21	87.84	CHANGED	.pcloplLpplcsGDstAsstLh.hlYp-LRRhAtsph.psE+hspsLpsoAL.Va-AalRhlstpch.chsuRsahauhuscsMRRILl-pARRcpppKRGGchhRtpLsp..ss.......hc.................sss-.lLsL--uLppLhs.hsPcpt+lVELRhFsGLohcEhAphLslShRTlcRpWthAR.sWhtpchps	..............................................................................................................................................h.l.tt.h...p.t..G.s..t.A.h.p..t....L.h.hh.a..pL.+.p..h.A.t.t.......h.......h....p...t...t..t.................s...t..s...................p.....s.........s.s..L...l.p..-.u.a..l...+...h......h...p............t.............p......h...p....s..........c....t...c....a....h.......t....h.....h.s....p.....h....h.....R...p.....h....l....l..D...t..t...R....p........p......t........s.......t.......K...........R.........t.........s......t....h.........h...h...p....l....t..t......t.............................t.t.................................................t.p......c....p....l....l.....t.......l.....c......c.....u.....L.....p.....p.......L.....t....p.....hs..s....c....p....t....c....h.l.p...L.p....a....h..s........G.....h..o..hpE....lAphL..s....l....S.....p....o....l....c....+....c....h....p.....hu....R..shlttt...t...................................................................................	0	83	100	112
+7467	PF07639	YTV		YTV	Studholme DJ	anon	Blast clustering of Pirellula proteome	Repeat	These hypothetical proteins in Rhodopirellula baltica contain several repeats of a sequence whose core is the residues YTV.	21.00	21.00	22.30	21.00	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.64	0.72	-4.23	18	108	2009-01-15 18:05:59	2004-03-16 18:00:16	6	10	10	0	52	113	196	43.40	40	33.91	CHANGED	oYTVphPVhETcp+shpYoVp+PVaETpsp..sYTVpVPshET+sp	......................YTVp+PVhETpp+shpYTVp+PVhETppc..sYTVp..+PVhETh.........	0	52	52	52
+7468	PF07640	QPP		QPP	Studholme D	anon	Blast clustering of Pirellula proteome	Motif	These Rhodopirellula baltica proteins share a highly conserved sequence, centred around an invariant QPP motif, at their N termini.  This motif may represent an export signal.	25.00	25.00	57.60	57.60	17.20	16.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-7.87	0.72	-4.28	9	11	2009-01-15 18:05:59	2004-03-16 18:04:46	6	4	2	0	9	11	0	36.00	49	13.76	CHANGED	MASsQPPLTRCGShNQQPspshpssttspph.s.ss	MASsQPPLTRCGShNQQPspuhpssthspph.shs..	0	9	9	9
+7470	PF07642	DUF1597		Outer membrane protein family (DUF1597)	Studholme DJ, Bateman A	anon	Blast clustering of Pirellula proteome	Family	This family of proteins are likely to be outer membrane beta barrel proteins. Possibly acting as porins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.28	0.70	-5.42	89	396	2012-10-03 17:14:37	2004-03-16 18:17:17	6	1	220	0	175	591	194	345.70	18	84.83	CHANGED	slpluGhl-shaphshsps.tst.....................hssps..sphsls.s.lhhptsssp......hshthslhaGstut.s.hs................................tsthhhsl.pAYssht....hscslslssGpasThlGaEsh.shsNhsao+uhhhp.s.PahcoGl+ssYssss.phshhhulhsG.....h................p.h...........ssss....t.shssplsa..tsstphslshshhhGsps.....t............................spssphh...hslsssaplss........phplshshsashtptt......................sssssssaaGssh...................................ahp..Yshs-...phuluhRsEaapsps...............................shsssssspshuhTlsssap................tsslhlRsEhRhs......p....stst........h..Fhps.ssps.......................spsthshssshtF	...........................................................................t.hphtGhlpshh.hs..sp...tst...................................hssps.........sphplst..h.lhhppssst..................hshhhphhhGstuths.hh...................................psththsl.pAalpht.....ht.p.s..lslphGphhohhGh.Esh...s...hs...N.h.a...o...t...u....hh.....hph..t.P..ah..psGlhs.sa..t.hss....phsh..hhulssG...............h.....................................................................psh.........................psss.............t.shhstl.sa...t.ssph..s..lt..hsshh..Gsps.....st.....................................................ststphh........hslhh.saph...s...c..............................p.hslsh..phs.ahtppt.............................s.stsss.haGssh...................................................................ahp........Ys..hsc.......phsls.......h...Rs.Ehapcsst.............................................................hsh.h.ss.ssss...h.h..shT.lsssap.........................................hsshhlRsEhRhc............p.......utss........s....hs.s.sst.........................sthhhshshhh.F...................................................................................	0	76	146	161
+7471	PF07643	DUF1598		Protein of unknown function (DUF1598)	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	A family of Rhodopirellula baltica hypothetical proteins of about 500 amino acids in length.	25.00	25.00	34.60	77.50	24.30	19.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.80	0.72	-3.95	9	18	2009-01-15 18:05:59	2004-03-17 09:12:34	6	1	9	0	8	18	20	83.70	38	16.70	CHANGED	CSIDPssEGLt+hppalpplsst....uthsstt...hhpshcpsLGhQ-lpVhGlssso+aARlLVEADY+MKRIuhGh-psslt.l.SY	CSIDPs.EGLp+hppalpplssp....sshsstt...hhssLcpsLGhQ-lpVhGlssco+hARlLVEADY+MKhIuhGl-psslt.lsSY.	0	8	8	8
+7472	PF07644	PGAMP		Planctomycete PGAMP	Studholme DJ	anon	Blast clustering of Pirellula proteome	Family	This conserved sequence is centred around an invariant motif of PGAMP in several short hypothetical proteins from  the planctomycete Rhodopirellula baltica. The motif also occurs twice in Swiss Q7UVK9.	20.30	20.30	43.70	43.40	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.85	0.72	-4.21	4	8	2009-01-15 18:05:59	2004-03-17 09:31:05	6	3	2	0	5	8	0	34.80	52	15.43	CHANGED	SlplPGAMP.AohphAhGQpsRhtpuQpppSphus	.SlplPGAMP.AoMphAVGQpsRhtKuQtQpSphus	0	5	5	5
+7473	PF07645	EGF_CA		Calcium-binding EGF domain	Bateman A	anon	Pfam-B_330 (release 10.0) 	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.08	0.72	-3.96	18	24503	2012-10-03 09:47:55	2004-03-17 16:01:14	10	2919	264	49	14019	30190	160	41.60	36	11.43	CHANGED	DlDECss.ss.psC...ttsshChNshGSFpCh....C.sGap......stssspsC	..................DlDE.C......t.........p........s........s.....t................C.............t.t...u..pCh...N...o.........G..S...a....p......Cp.....................C.....s..G.ap...............tt......................................................	0	4262	5341	9307
+7474	PF07646	Kelch_2		Kelch motif	Finn RD	anon	Context Domains	Repeat	The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.22	0.73	-8.44	0.73	-4.00	42	698	2012-10-05 17:30:42	2004-03-17 16:09:08	10	211	235	0	334	6336	157	51.00	22	11.00	CHANGED	sphstsss.sh.......ssclhlhGGh...................s....phhhhcsppppWpphsshs	...................pssauss..sh............ss+l.hlaGG..h................................................................ttt.t.s..p...h..........s.-..l...h...hhD..h..pphpWpphp........................	0	102	166	239
+7475	PF07647	SAM_2		SAM domain (Sterile alpha motif)	Finn RD	anon	Manual	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.10	0.72	-4.13	49	3625	2012-10-02 20:42:54	2004-03-17 16:20:05	12	358	360	47	2049	7757	90	64.90	20	8.61	CHANGED	sphhshpslspWLp...sl..sh..tpYp-tFpppslss.phl..hphstccL...t.clGlpphscpp+llpplpphp	...................................hs.pplt.....p.W.Lp...........sl.........sl.....p....pYs.s......t....h.......p........p...p.......s.lsu.ph.l.........hph.s..p.p...p...L.................p..plu..l..ss.h.tp..Rp+lhpthpth.............................................	0	524	798	1345
+7476	PF07648	Kazal_2		Kazal-type serine protease inhibitor domain	Finn RD	anon	Manual	Domain	Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.	20.30	11.00	20.30	11.00	20.20	10.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.48	0.72	-4.02	73	4760	2012-10-02 00:52:43	2004-03-17 16:59:37	10	287	248	41	2600	6229	320	42.20	27	13.16	CHANGED	Cspppt..P..VC......GsDGp...oYss..tCthpstshpt...........ptp..hphhppss.C	................Cspt.....P.....VC..............G..s.D...Gp...........TYs...s.......tCth..pp.ts.stt.....................ttp.....hph.hh.s.C................................	0	733	989	1694
+7477	PF07649	C1_3		C1-like domain	Finn RD	anon	Context Domains	Domain	This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in Pfam:PF00130.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.89	0.72	-3.91	194	800	2012-10-02 13:15:50	2004-03-17 17:46:33	7	64	28	1	533	923	2	29.60	35	11.59	CHANGED	htCps.Cshshtt....shYt..C..h.pC.cFhl.HpsCs	......hCss..Cs..hshpt.........hYt....C..h.pC.cF.hl.HppCs.	0	367	463	489
+7478	PF07650	KH_2		KH domain	Finn RD	anon	Context_Domains 	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.58	0.72	-4.42	165	9989	2012-10-02 00:34:43	2004-03-17 17:57:18	12	35	5164	213	2428	7426	3812	76.60	27	28.69	CHANGED	cl.phlptpl.p.....tss.......huplpI..........ptshlsl+suc.GllIG+pGpplcplppplccpht.h.spp..............Vtlplh..cVccs.t	...........................................cl.phls..hcl...p............tss.............hupl.cI................ptshls....+..su+.Gl..VIGK..pGp..c...lcc..lt...pphcc.h.......spp..........................Vplplh..cV+ps.............................................................	0	805	1574	2054
+7479	PF07652	Flavi_DEAD		Flavivirus DEAD domain 	Finn RD	anon	Pfam-B_199 (release 3.0)	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.84	0.71	-4.45	19	6300	2012-10-05 12:31:09	2004-03-18 10:02:46	9	76	281	64	1	7229	89	121.90	49	4.66	CHANGED	h+KtplTlLDhHPGAGKTR+lLPpll+cslc+RLRTllLAPTRVVhuEMtEAL+GhslRapTsAl.sp+sGspIVDlMCHATaTpRhLp.Ps+hsNaplhIMDEAHFhDPuSIAARGalsopschscsAslaMTATPPGos-PFPcSNu	.......................................................................h......................................................................................................................................................................................................................sa.u...T.as..h.h...L...hs.....s.....s.....p..s..s.s.YslIIhDEsH....h..TDss.....S..I..huh.G.h.l...s..p..s.E.h.u.t..A.t.s.l.h.h..TAT.PPGSs.shPpup........................................	0	1	1	1
+7480	PF07651	ANTH		ANTH domain	Finn RD, Bateman A, McMahon H	anon	[1]	Domain	AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.\	   The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats [1,2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.80	0.70	-5.70	29	1195	2012-10-02 18:21:09	2004-03-18 10:47:20	11	20	303	13	707	1532	5	243.60	25	36.38	CHANGED	.sslphulhKATsp.p-sPsKc+asctIlhhops....tphsthhtslscRlspopsWslshKsLlllH+lLp-Gc.shhp-hhptppphsphtphps................shsaushlRpYstaLpc+lphatpttht...........hphttpt....................tp..tt........phsh.pll-pl.plQphl.phlphp.pssshp..spllltAhh.llp-shtlYptlschlhsLlp....phh-..hth.pscpshslhc+htpQhccLppFaphs+slthhps...IPpl.chssshlpsh-phhpps	............................t..ththslhKATst....ss.Kp.+ah.p.......l..h...h..h.s........pt..........h......p..h.......s....thh..sl.hcR..h.......s..t..s.....s....hl.........lsaKsLlshH+lh.p.c.......G....p...........p..hh.p..........ph.h...p..t.p.s..h..h..p...t..hst.....hsp......................................shshu..s...hlR....pYspaL..pp+.htha...pphsh...........................hph.cpt..................................................................tpss.t............phsh..pLLc.ph.hlQ.............p..l.s.hlp.h...p...t........ss.....ths....stsh.suhh.....l.hp-shplathhschlhsLh..p.............................phh-..h...................scphhtl.hc.+ahpphpcltc.Fhph..scp.l.t.....h.......pt....lPpL......p.....sPsshlps.-ph....t.......................................................................................................................................	0	180	352	538
+7481	PF07653	SH3_2		Variant SH3 domain	Finn RD	anon	Manual	Domain	SH3 (Src homology 3) domains are often indicative of a protein involved in  signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.60	0.72	-4.47	35	4617	2012-10-02 18:48:24	2004-03-18 11:11:45	12	450	402	69	2334	20355	74	59.20	23	7.44	CHANGED	hhpshpcass..s.ssss.................LshpcG-...llplh..........................tp..css.........sa.ahs.pp..s.......Gct......GhlPpshlp.h	..................................hpshhcass......p..ssst....................Lshp.c.G.D...............ll..p.lh...........................................pp...pss.............sa..WpG..ph.....s...................................G...ct.................G..h..hPsshlp......................................	0	522	751	1381
+7482	PF07654	C1-set		Immunoglobulin C1-set domain	Bateman A	anon	Bateman A	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.91	0.72	-3.98	128	16594	2012-10-03 02:52:13	2004-03-18 16:21:17	10	70	510	2328	2190	24856	1	82.80	38	31.24	CHANGED	s..pss.ph...sptshLsChVssFaP..sslpVpW.h+NGpplspsspsst.h..s....sDhoaphhotLphs...P.pps-..tYoCpVpHtuLp..psht	...............................................scpsoLtChs.h.G..F.Y.P....sc..I.s.l..oW............+.....s......G......c.........-......t.....o......p..c....s...p..h.....s..p......shs....s.............GDs...T..F..Q...p..hut..l.sls............s..sc..pp...pY.o...CcV..pHpuLs.pPl.s...................................	0	174	356	861
+7483	PF00008	EGF		EGF-like domain	Bateman A, Sonnhammer ELL	anon	Swissprot_feature_table	Domain	There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam).  The family is hard to model due to many similar but  different sub-types of EGF domains. Pfam certainly misses a number of EGF domains. 	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.34	0.72	-3.96	71	24995	2012-10-03 09:47:55	2004-03-18 17:40:01	22	2546	284	90	15241	25121	202	32.00	40	10.56	CHANGED	Cspp....sCpst..GpChps.........ssapCpCs.G.....asGpp	................Ctss........PC.pNG....G..s..C...h..cts.......................ss..ap.CpC.ssG.......asG...................	1	6681	7484	11311
+7484	PF07655	Secretin_N_2		Secretin N-terminal domain	Yeats C	anon	Yeats C	Domain	This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggest that this family may be functionally analogous to Pfam:PF03958.	22.00	22.00	22.20	22.00	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.12	0.72	-3.60	60	476	2009-01-15 18:05:59	2004-03-19 11:19:25	8	5	427	0	107	379	37	91.00	28	16.70	CHANGED	TcTFslsYLthcRtGtSpToVsSGslSssss...sssssssssss.................sssssususSu....sussGopIpopscoDFWs-LcpslpullG.susGRtVlssPQA	.....................TcTaslsalphpp...pSto..olso......Gshossss........s................................................ssuusususou......susuusphpssscsDhasslcpslpshL..sstGphslsssp...........................	0	24	71	88
+7485	PF07443	HARP		HepA-related protein (HARP)	Vella Briffa B	anon	Pfam-B_21761 (release 10.0)	Family	This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues [1]. Family members may contain more than one copy of this region.	25.00	25.00	26.20	27.90	23.30	22.10	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.63	0.72	-4.59	15	154	2009-01-15 18:05:59	2004-04-01 10:52:49	8	9	78	0	90	142	0	54.50	44	11.43	CHANGED	FpVcl.GYppcLIAlFKslPS+sYDssT+pWsFuLcDYptLMcplpcL.spVsLcPL	.............FpVcl.GYst-LIulFKphPS+sY..Dsp..T+pWsFpLpDYstL.h..ptspsL..spVpLpPL............	0	18	25	53
+7487	PF07657	MNNL		N terminus of Notch ligand	Liu XH, He QY, Studholme DJ	anon	Liu XH	Family	This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins.	22.50	22.50	23.60	22.70	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-9.86	0.72	-4.05	24	383	2009-01-15 18:05:59	2004-04-06 17:22:07	8	106	95	0	183	325	1	75.10	44	9.34	CHANGED	uSGhFELclpsapNtpG...tsGpCCsGs.......stthshspCcTaFRVCLKHYQuplsssu...PCTaGsssTPVLGuNohslp	...........sSGhFELplp.phpNhpG.L.tsGpCCsus............ttt..s..stCcTaFRVCLK........cY.Q.u.p...Vospu..........................PCoaGsusTPVLGsNoFsl.........	0	35	54	113
+7489	PF07659	DUF1599		Domain of Unknown Function (DUF1599)	Yeats C	anon	Yeats C	Family	\N	25.00	25.00	26.60	28.10	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-9.02	0.72	-3.91	14	429	2009-01-15 18:05:59	2004-04-07 15:17:06	6	2	231	0	116	393	387	61.80	51	66.07	CHANGED	Kh+DYGsA....WRlhRlsSlTDQIaIKApRIRslpp.pupohVsEGIcuEaIulINYulhuLIQL	.......KsHDYGpA....W....R.........h....R...lo....SlTD.IhhKhpRl+pIE.....s..pGp.olV...s.E.GIcupahsllNYulhuLIpL.....	0	49	100	112
+7490	PF07660	STN		Secretin and TonB N terminus short domain	Yeats C	anon	Yeats C	Family	This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.20	0.72	-4.40	154	4169	2009-01-15 18:05:59	2004-04-07 17:23:43	9	51	1462	20	1089	3747	285	50.20	21	6.20	CHANGED	hslhhs.t..ptlps....ppsul...p.ss.h......slppuLpplLpssslphph.ssspl.hlttp	......................................phhhs.....stlpu...........tssul.......phss.h......shcpuLpplL.pu..s.GLshph..psshl.hlt...............	0	353	719	943
+7491	PF07661	MORN_2		MORN repeat variant	Yeats C	anon	Yeats C	Repeat	This family represents an apparent variant of the Pfam:PF02493 repeat (personal obs:C Yeats).	24.40	9.20	24.50	9.20	24.30	9.10	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.95	0.75	-7.19	0.75	-3.26	354	7333	2012-10-01 20:24:03	2004-04-08 11:38:36	8	45	575	0	1184	6471	5210	21.70	28	29.73	CHANGED	hpGhhptYapsGplppct.pacs	.............pG.hppYa.c.s.Gplppct.pYps............	0	627	928	1065
+7492	PF07662	Nucleos_tra2_C		Na+ dependent nucleoside transporter C-terminus	Bashton M, Bateman A, Yeats C	anon	Yeats C	Family	This family consists of nucleoside transport proteins. Swiss:Q62773 is a purine-specific Na+-nucleoside cotransporter localised to the bile canalicular membrane [1]. Swiss:Q62674 is a a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine it also transports the anti-viral nucleoside analogues AZT and ddC [2]. This alignment covers the C-terminus of this family of transporters.	25.30	25.30	27.20	27.10	25.10	24.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.29	0.70	-4.86	161	4136	2009-01-15 18:05:59	2004-04-08 14:27:54	8	11	1902	1	688	2281	695	208.40	39	50.08	CHANGED	aLluAShMuAPuuLlhAKllhPp.....ocp.sp.st........tpt..............................sNll-AhupGAhsGhplAlsVuAMLluFlALlAllNulL.uhl...G.........h............Gh............l............oLphILGalFuPlAallGV.P.a.sEshhAGullGpKlllNEFVAahsLs..phhss...............LSt+otsIloaALCGFANhoSluIhlGuluuls.PpR+sslAc.hGl+AlluGoLuslhSAsIAGlhl	...........................................................................YlluAsl..hsh.uulllupllsPhs.psppsh..........................................thtp..........cp............cspshh-hhup.ushsGh.........KlAlsVuAMLluFlAL.IAhlNull.u.sl.......sshh............Gh..............l..........................ohpt.....IlGYlFuPlA......alhG........l........P....h........s.......-A.hhuGolhupKLlhNEFVAhhsls..phhss...................................LSs+otuIlohhLsuFANFSSIGIllGulpu.ls.sc+s.st.lu+.hGl+hlhuuTLsslhSAsIAGlhl..........................	0	182	343	518
+7493	PF07663	EIIBC-GUT_C		Sorbitol phosphotransferase enzyme II C-terminus	TIGRFAMs, Griffiths-Jones SR, Yeats C	anon	Yeats C	Family	\N	25.00	25.00	41.50	41.50	18.90	18.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.03	0.72	-3.86	9	882	2009-01-15 18:05:59	2004-04-08 14:30:57	6	5	806	0	77	379	42	92.40	78	28.81	CHANGED	LSPlLGPGAVIAQVIGV.LIGsQIGtGsIPPphALPALFAINsQsGCDFVPVGLuLuEAKPETVclGVPAVLhSRhlTGsluVlIAWhhShhla	.......LSPhLGPGAVIAQVIGV.LIGVQIGhGNIPPpLALPALFAINAQAACDFIPVGLSLAEA+t-TVcVGVPSVLhSRFLTGsPsVLIAWhsShhlY............	0	24	39	62
+7494	PF07664	FeoB_C		Ferrous iron transport protein B C terminus	Bateman A, Yeats C	anon	Yeats C	Family	Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N-terminus has been previously erroneously described as being ATP-binding [1]. Recent work shows that it is similar to eukaryotic G-proteins and that it is a GTPase [2]. 	26.40	26.40	26.70	26.70	25.60	26.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.74	0.72	-4.54	217	3526	2009-01-15 18:05:59	2004-04-08 14:37:58	7	16	2806	0	775	2731	228	54.20	34	7.91	CHANGED	llhulY.llGllsullsuhllp..pplhpup.sss...FlhELPsYRhPph.+slhhpsWp+	.......slhulY.llG..I.lh.All.suhlL+....pT.l...h+G..c....sss....FlMELPsY+lP....pl.+slhhpsWp+.............	0	304	565	683
+7496	PF07666	MpPF26		M penetrans paralogue family 26	Studholme DJ	anon	[1]	Family	These proteins include those ascribed to M penetrans paralogue family 26 in [1].	21.30	21.30	21.80	21.40	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.85	0.71	-4.25	11	22	2009-01-15 18:05:59	2004-04-13 10:35:31	6	1	12	0	13	21	3	104.00	25	67.62	CHANGED	hlphl+pl++luhhhllhahlssh.....llhlsllsalshhhp.p.hsp......s...h.hhhsllhlhlssl...hhIsphllpIlLhlKlsthKscpscapchphahhLhIlGIhl.slhulIssFhLs.KhpK	....................................................................t.hslGlL.Ihhssl...hhlhthILsIlhhlhsuphppcp.phtc..hphlLsIIGIll.slhslIsslhL............	0	11	12	12
+7497	PF07667	DUF1600		Protein of unknown function (DUF1600)	Studholme DJ	anon	BLAST clustering of M. penetrans proteome	Family	These proteins appear to be specific to Mycoplasma species.	25.00	25.00	48.60	48.60	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.78	0.71	-3.98	12	25	2009-01-15 18:05:59	2004-04-13 12:35:20	6	1	9	0	12	21	0	116.40	30	43.30	CHANGED	thhSslahHlhtPhh.Flhhhalhhshs.hhshpphhKhLlhshIYPhlYs.lYlhslPal...ahhtss..ssYoVYuhhTssp.s.hh...................uhslhhshhhlahslShlh.lhhphhthpchh	.....t.lhuslalHllsPls.FllsGalhhsas.tpsh+chtKaLlhshIYPhIYu.lYlholPal.................ahhssG...ssYSVYGhhTNsppNshh...................AhsllhshhFlaaPlSahl.lhhpahthpc+........	0	10	10	10
+7498	PF07668	MpPF1		M penetrans paralogue family 1	Studholme DJ	anon	[1]	Family	This family of paralogous proteins identified in Mycoplasma penetrans includes homologues of p35 [1]. 	20.30	20.30	20.30	20.30	20.20	19.80	hmmbuild  --amino -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.21	0.70	-5.26	30	71	2009-01-15 18:05:59	2004-04-13 12:59:48	6	3	5	0	55	69	0	290.00	34	77.48	CHANGED	TPcLKosVsLuGuLocIYDosss.....csTNsLIAc-IKsN.-sh..FsNGs-...hcslpshslTVcGsF....osSoW..sGpsYs.stps....W.........sshssssKllYsosusQlsIuSLsDLKopLsc.....psplKphLcsAssohss...sosaoV..pNpLGhT........s..sDLLHVNVpusp.......sssspNaDLQIPVSslNLplosLsloV......oGsNltsssctTTsFsYNIGI.cssssaspssssssssp.....s-sssusclLpcLGYss.t....................sssssLsNDplupuLGlYNspFo........t.tssssssssssspsYTlTLsAoP..spsYVW.DDG.oossKslSFsVslsls	..........TPplK.sslsLsGuLocIYDosss............csTN..pLIuc.-IKsN..psh..FsNGpc...hpslpshsloVsGsF....spS..sW.sG..t...s.Ys.s....W..............shsshsplhYsssusQls....IsSLsDLK.opLsp......tsplpphlptu.shshss...sssapl..p..NplGhT..........ssDLlHVNVtssp..........sssshshDLQIPsSslNLpls..sLploV......sGsN..ltt..s..sphoTsasaNIGI.csss...paspsss...tss.hsp.......sptssssplLtpLGass..t..........................ssshsLss-tlutuLGlYNspFo.............ssssspsssttYslolpAoP....spsYlW.-DG..osssK.ploFssplp..s...................	1	55	55	55
+7499	PF07669	Eco57I		Eco57I restriction-modification methylase	Studholme DJ	anon	BLAST	Domain	Homologues of the Escherichia coli Eco57I restriction-modification methylase are found in several phylogenetically diverse bacteria. The structure of TaqI has been solved [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.53	0.72	-3.68	29	913	2012-10-10 17:06:42	2004-04-13 13:56:19	6	28	738	0	199	3032	536	109.80	25	13.17	CHANGED	MK...FDVlIGNPPYQhss...tst..tss..............spPIYphFl-hAhclt...s+alshIhP.uRWh.tuGcshcpaRpphLpDp+lpplh.a.supclFssssIcGGlshhhh-.psp	............................................................................h....FDhlIGNPPYhct..p...p.......t..t...h.t.....htp................................................................tssslY...t.....h..F.h.-....t.....u.h..p..lhp........sGh.l.s.a....I..s..P...spah...pup...h..s...c.p.h.Rp.....h.l.l.p.c........s.p..l....pp.l.hp.h.s.s.........t.....p..........l.F...p...s....s..s..l...psslhhh.+t...t.............................................................	0	84	151	182
+7500	PF07670	Gate		Nucleoside recognition	Yeats C	anon	Yeats C	Domain	This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337) [1]. In the FeoB proteins (e.g.  Swiss:O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity [2]. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.36	0.72	-4.15	238	13008	2009-01-15 18:05:59	2004-04-13 14:15:06	9	26	3306	1	2612	8940	1060	117.90	18	34.76	CHANGED	hhphhshllhhhhllslLpph................................................Ghhshluphlssl.hp.l.Gh...sspssls.hlss....hhstpsulshhtphh..............................................................................t...hstpct.hshhh...hshh.hs..........shutl.s..shh...thhuhh	...........................................................................................................h.hphhshllhhhh...llslLpph..............................................................................................................................................................................................Ghhshlutlh.ssl.h.p.l..Gl......ssp..ss....ls...hlsu....h.h.s.s...t.s.s.ls.s.s.t.plh............................................................................................t.....hs...t...p...p...t...h...s...h...hh.......h.shh....hs.........shuhhs....hhh......h........................................................................................................................	0	936	1758	2209
+7501	PF07671	DUF1601		Protein of unknown function (DUF1601)	Yeats C	anon	Yeats C	Family	This repeat is found in a small number of proteins and is apparently limited to Coxiella and related species.	19.00	4.00	19.10	4.00	17.90	3.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.05	0.72	-7.52	0.72	-4.31	28	131	2009-09-12 22:43:26	2004-04-13 16:55:19	6	24	19	0	48	143	226	32.00	31	18.14	CHANGED	MGh+WpcLctQcLosRLLsAl+.....+Ns-pFNsQsIANTL	............................................LhpAlt..........ppspcFNsQpIANsL....	0	32	43	48
+7502	PF07672	MFS_Mycoplasma	MFS_Mycoplamsa; 	Mycoplasma MFS transporter	Studholme DJ	anon	BLAST clustering of Mycoplasma proteome	Family	These proteins share some similarity with members of the Major Facilitator Superfamily  (MFS).	20.80	20.80	20.90	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.03	0.70	-5.22	7	58	2012-10-03 03:33:39	2004-04-13 18:09:49	8	1	45	0	19	92	2	252.00	30	55.53	CHANGED	p+pKohlSshNhaGFNlGhhlshs.Flhs.slppsuops..WhhIhoshILllhshLllahhFtpch..hhsp..KQoK.p.shssc......sohhslLKpKpTaKhhshaGlhLlslV.shTsshhN.l.ls.SP...hsl.............................suGhhhhshshhhIhaVhGahhGhhsloPFNKThacRK+althhhshshlhlllhllh.uhhlGhssshGhsh......hhIhoFluGsFhWulQushLhlPaEhKthp.scVulhFGhlWGhGYlhYThhDIhhSshhp	.................................+pKullSphs.ahaslGsllsllP.F..lhs...ps..s..p..thpss..Wphlhslhu.LLshIPLllahlh..GpcFDhhtsp....ppst....p.t.ts...........hslhshLKpKsTatWlllYGuWL...llsV.a..sho.s..hh...p.h...thSs....................................ssphs.thhpha..Ih.Fl.h.uhhlG..hslGhas+hphcR+halsh....hhshGllhh...ll...uhlh....sh.thGhs...ps.uhth....................hhIhuF..LsGhhh....WGIQuVhL.lPHEYKss.sPpplGhhFulIWGhGYhhaTlshIllSsh....................................	1	11	16	17
+7503	PF07673	DUF1602		Protein of unknown function (DUF1602)	Studholme DJ	anon	Clustering of A. pernix proteome	Family	\N	24.20	24.20	25.10	24.70	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.70	0.72	-4.49	43	115	2009-01-15 18:05:59	2004-04-13 18:16:47	9	3	81	0	21	116	7218	37.50	42	17.33	CHANGED	GSStsphtG.hssARAhATRCCpPP-SssGhhhut.u...spP	......GSStshhtGthspARAhATRCphPP-sshGhhhtt.u..pP............	0	5	12	17
+7505	PF07675	Cleaved_Adhesin		Cleaved Adhesin Domain	Yeats C, Collyer C	anon	Yeats C	Domain	This is a family of bacterial protein modules thought to function in various roles including cell adhesion, cell lysis and carbohydrate binding [1].  The beta-sandwich jelly-roll topology of these modules is known as the galactose-binding domain-like superfamily, clan CL0202. A tandem repeat of these modules (either two or three repeats) constitute the haemagglutinin/adhesin (HA) regions of the gingipains, RgpA, Swiss:Q51816 and Kgp, Swiss:P72194 and Swiss:P72197 [3] expressed by Porphyromonas gingivalis (Bacteroides gingivalis) [2].  They form components of the major extracellular virulence complex RgpA-Kgp - a mixture of proteinases and adhesin domains [4]. The adhesin domains in this complex are found in proteinase-cleaved forms when isolated from the cell surface [5].  Haemagglutinin genes of P. gingivalis [6] (hagA1 HAGA1_PORGI - Swiss:P59915 - and hagA2 HAGA2_PORGI - Swiss:Q51845) suggest that such proteins are composed of eight to ten tandem repeats of these adhesin modules [1]. Genomic data predicts that homologous protein modules are also expressed by a number of other bacteria and form part of putative multi-domain proteins, eg. Swiss:Q26BR9 and Swiss:B0VGL6. These domains may be acting in concert with other adhesion modules thought to be part of these multi-domain proteins such as fibronectin type III, Pfam:PF00041, and Meprin, A5, mu (MAM), Pfam:PF00629, domains.	20.50	7.00	20.80	7.10	20.10	6.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.25	0.71	-4.66	9	203	2012-10-03 19:46:52	2004-04-14 13:37:02	6	31	36	6	40	218	69	157.90	28	23.51	CHANGED	stlL.EuFEsG.lPsuWpsIDADGDGtsWtphsssh.......hsGHsustCshStSa.lshhGs...LTPDNYLITPcl....pGut+lpYWVssQD.ssasuEHYAVhsSoTGssAuDFs.lLaEET....hTuKs.............pGsWhpRTlsLPAGTK...YlAFRHasCTDha..alhLDDVsl	.................................................................h....Es.p..p.s...h.s.stWphI.......Duc.u........D..u.p.sWhhhs..s.s...........................hsu+su.st.s.sh.S.h....u...h...s.h..tt.......hs.s.DN..aLI..oPpl.....sG.s.p..p...lpaass...s...ps....t..s..a.s...s...EcY....s...VhhS.s..T...G..s........ss..usFs...hlh--s....hssts..............tusWhppolsL...P.sGT+....YlA.aR..H..h.s.s..o..D....h...h...h.l.hlDDlp.....................................................................	0	29	40	40
+7506	PF07676	PD40		WD40-like Beta Propeller Repeat	Yeats C, Mistry J, Adindla S	anon	Yeats C	Repeat	This family appears to be related to the Pfam:PF00400 repeat This This repeat corresponds to the RIVW repeat identified in cell surface proteins [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].	20.60	10.90	20.60	10.90	20.50	10.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.99	0.72	-4.23	127	15082	2012-10-05 17:30:43	2004-04-15 11:18:12	7	349	2793	58	5424	14558	9482	34.90	24	15.47	CHANGED	hpplssssu............stsPsaSPDGpplhFsSscs......Gs.p.....lah	.................................................h........t...............................ptsP.saSP.DGppls....aso.p.ps..........u....................................	3	2058	3763	4721
+7507	PF07677	A2M_recep	A2M2; 	A-macroglobulin receptor	Studholme DJ	anon	Prosite	Domain	This family includes the receptor domain region of the alpha-2-macroglobulin family.	21.70	21.70	22.00	21.70	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.86	0.72	-3.80	92	1246	2009-01-15 18:05:59	2004-04-16 09:26:22	9	72	186	60	533	1171	2	88.00	30	6.72	CHANGED	osMsll-lslhSGFtsspssLcpLppstphh....lp+hEh.....psspVllYh-plsppp.hClsFphpp.phtVuth.pPAsVpVYDYYps....sppssphY	.................................SsMull-lslhSGFhsspsslp.pLp..p.s.sphh........+hEh......psspVllYh....-...pls.pp.p............pslsh.pspp.phtVut.h..pPAsVplYDYYp.s....pcpssthY.............	1	90	147	332
+7508	PF07678	A2M_comp	A2M3; 	A-macroglobulin complement component	Studholme DJ, Sammut SJ	anon	Prosite	Domain	This family includes the complement components region of the alpha-2-macroglobulin family.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.86	0.70	-5.14	43	1721	2012-10-03 02:33:51	2004-04-16 09:40:48	9	109	288	67	626	1697	23	213.90	31	19.09	CHANGED	pGYp..RpLsYK.+sDG..SYSsF......pst....suSTWLTAFVlKsFu............pA+pa..IhlDppplppulpWLlpp.Qpss.GsFppsu.lhpptMpG..Gl.........-scloLTAalsIALhEst...........hsps..............................psuls+AhthL.cst......ssshspsYshAlsAYAhsLss.cpsptpphhppLcppAhpc............................sss...haWppsppsp..sptt..................ssuhpVEhTAYsLLs.hlst...........p-lshAptIlpWLspQpNstGGFpSTQDTVVALpALocYut	.......................................................................................................GYp..ppLpa+....+t..D.........G...Sausa.....tpt................suSs....W..LTAaVh.+.s.ht............tApph....h..l...-....phl.ppuhpWLhpp..Qp.s.s..G.pF.p.....-...sG...l.h.pp..sh..pG..Gh.......................................ppsluLTua...lllALhE.st....................hsph.....................................psslp+u.hpaL.ppp.........htph.pssYs.h....Al...su.YA..htLs...pp.......tt....pthh.p.pLt..th.u..hpp............................ss........haWtpst................................hplE.hTuYsL..Lu.hl.t...........pcht.tu.....lhpWLspQp.p...G..GFs..S.....T.Q...D..T..hluLpALspa..h....................................................................................................................................................	0	122	188	400
+7509	PF07679	I-set		Immunoglobulin I-set domain	Bateman A	anon	Bateman A	Domain	\N	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.92	0.72	-4.13	48	59728	2012-10-03 02:52:13	2004-04-20 17:44:00	11	3030	1617	375	30033	71682	78	88.50	21	29.33	CHANGED	PpFsph..pshplptGpssphpCplpGs.PsPplsWh+s..sp.lps............spchplptps......sptoLpIpssphsDsGpYsCpApNp.sGpspssspLpV	.................................................................................ps..h..p...s....h....t....G...p.....s...s...p...l...p....C........p.......s.......p..........G...........p.......P.....t...........P..........p.........l........p.......W..h..+s.........s.p........l..p.s.....................................................s.p...c...h..p....l..p.t.ps........................t..p.L...p...I....p.....s......s......p......h......p......D.......s.......G...p...Y...p.C..h....A....p....Nt....h..G...p..s...p.t.p.h.tl...................................................	0	6694	9324	18688
+7510	PF07680	DoxA		TQO small subunit DoxA	Kletzin A, Studholme DJ	anon	[1]	Family	Thiosulphate:quinone oxidoreductase (TQO) is one of the early steps in elemental sulphur oxidation.  A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused together in a single polypeptide in Swiss:Q8AAF0.	20.70	20.70	20.70	23.90	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.55	0.71	-4.53	9	80	2009-01-15 18:05:59	2004-04-20 18:14:37	6	2	72	0	25	79	2	135.30	31	48.50	CHANGED	hhassllGsLhNhSKhPclc.lshhphpsss....LhhplsclsGPDsYsuhlshlplhsusucllLppss......clsphPhsphKs-Ylshhu..........ulhlsLGucAplpLplP..hcLs..GTYplKLassu..Gtssttthpa	...................................hp.tshGsLpNhShtPthp.lus...t.hpsss....LphplaRspGsDsYGuFlltlpLhs.s.s.Gcl.lhphsu.....ppLuplPtssIcNcY.s.s+.hs......sutaulhlPLGucATlplp.hs......hpls.pGs.YpLpLhDlu..Gtsapt....h.....	0	8	17	22
+7511	PF07681	DoxX		DoxX	Studholme DJ	anon	BLAST	Family	These proteins appear to have some sequence similarity with Pfam:PF04173 but their function is unknown [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.74	0.72	-3.56	103	6635	2012-10-02 13:32:46	2004-04-21 11:57:59	7	10	2739	0	1741	5119	2239	87.30	23	51.92	CHANGED	ulLlhRlhluhlFl.hpGhpKlh..................shsu..........ssthhs....shsl..................sshhuhhushsElsuulhlllGlhTR....huAhhlsshhlsAh....hhsHt	..................................................hhlhRlhlu....h.l....F....l....htG.h.t.Klh.............................shss.........................................ht.t.hht..................sh.u.l.................................................ss.h...h....s....h...l.s...s....h...sEls.uGl.hll...l.......G.......h.......h..TR.......h.u..A.h....h..hs.h.h.h.l.ssh.....hhh........................................................	0	475	1065	1446
+7512	PF07682	SOR		Sulphur oxygenase reductase	Kletzin A, Studholme DJ	anon	[4]	Family	The sulphur oxygenase/reductase (SOR) of the thermo-acidophilic archaeon Acidianus ambivalens is an unusual enzyme consisting of 24 identical subunits arranged in a perfectly symmetrical hollow sphere and containing a mononuclear non-heme iron centre (personal communication: A. Kletzin). At 85 degrees C in vitro, elemental sulphur is oxidised to sulphite, thiosulphate and hydrogen sulphide with no external cofactors needed. The proposed equation is:  4S + O2 + 4 H2O ---> 2 HSO3- + 2 H2S + 2 H+.	25.00	25.00	191.60	191.40	22.80	16.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-12.12	0.70	-5.83	3	21	2012-10-02 00:20:33	2004-04-21 13:41:55	6	1	16	25	7	26	2	295.40	54	97.85	CHANGED	PKPYVAINMA-V+N-PKThELFupVGPKVCMVTARHPGFVGFQNHVQIGVlPLGsRFGGAKM-MocEhc.............oLcLhQYThWKcWKDHEEMH+QNWupLFRLCluCAoQMVWGPaEPIYEI+YANMPlNTEMTDFTsVVGKKFApGc..sluIPsISQPYGKRVVAFGEHpVKEGhEcQFEEuAIKTLEhF++.APGFLGuMILKEIGVSPlGSFQlsuKGFHQlLESsGul-PcsssTI...YpsPEF+....s+PpcYIVHsEWScs-ALMFGhGRVLlsPElRcVHD.KVLDTLlY.GPYIRVlNPlMEGTaWRE	.....hlAlN.sclhNt.pohphh.pVGPKVCMVTApHPGFVGFQNHlQlGllPhGsRYGGAKMDMscE.s.............sltlhQYThWKDWKDHEEMH+QNauhlFRLChSChuphl.GPWEPlYEIlhAsMPhNs-MTDFsuslGccFApGc..PhslPsIS.PYGpRVVAhuEHoVhPG+EKpFE-uIl+TLEhhK+.APGFLGhMlLKcIGVSuIGShQhsscGhHQlL..EosGuh.Pcssssh....aps..PEA+.....sTPppYlVHhEWuss-uhhFGhGRVllpPElRplHD.cVL-TLlh.GPYIRlhNPMMEsThWRE.	0	3	5	7
+7513	PF07683	CobW_C		Cobalamin synthesis protein cobW C-terminal domain	Bateman A	anon	Pfam-B_1247 (release 5.4)	Domain	This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis [1] and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.18	0.72	-4.27	158	5707	2009-10-26 17:34:02	2004-04-27 12:18:52	9	25	2706	1	1476	4245	1150	96.90	22	27.04	CHANGED	lpohshptcpshc.....ppltphlpp.......hs........ts..llRsKGhltls....sp.st.hhhhptlsthhpht.ht..hts.............................ts+psclVhI...Gp..sl-...pptlpptLpssl	.....................................................pohshp.t.ctshc.....pph..p.hlpp................hs......................................ss...llRhK.Ghl..h.ls.................sp...s....p...hh...hhp........tstt.h.hphp.....h....s..........hts..............................................................tstpsclVhI.........Gp....sl-....pst....lpptlpt..................................................................................	0	401	896	1201
+7514	PF07684	NODP	NOD; NOD1; 	NOTCH protein	Guo J, Studholme DJ	anon	Guo J	Family	NOTCH  signalling plays a fundamental role during a great number of developmental processes in multicellular animals [1-2]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be  elucidated.	21.90	21.90	27.00	23.80	21.40	20.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.10	0.72	-4.37	28	312	2009-01-15 18:05:59	2004-04-27 13:03:59	7	249	96	8	140	249	0	61.70	36	3.09	CHANGED	cltGolVaLElDNRpC...ppsscC.FpsAssAAsaLuAhusp.psLph.saPIpsVpups.psssss	............hGSlVaLEIDNRpC.............psuspC.FpsssssAsaLuAhAup.ssLp...sYPl.sVtucs.ts....s..............	0	26	38	81
+7515	PF07685	GATase_3		CobB/CobQ-like glutamine amidotransferase domain	Bateman A	anon	[1]	Domain	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.64	88	5307	2012-10-03 00:28:14	2004-04-28 09:26:43	9	29	2967	0	1396	9246	3546	155.60	25	37.14	CHANGED	ssph.s.ssDhlllPGo+ssht-Lthhc.ppuhccslpphhppGt..llGICGGaQhLGcplt.....ct.....shss...hpGLGlLshpTthpp.pKtlspspspsht..........pshtlpGaEhHhGpohh.sst..hhhh...............tsthc.....ushs...psslhGTYlHGhatsssh	....................................s.....s.ssD.h.lh.l.sG..u....p...s......p...h......p......s......h......t.....h......tc......tp...s......h.p...p...s.l..p...p...t....h...p.....p......G...t......s..llulCG.G.aQ.hL.Gcp..lt...............................sss.u....hp.G.lGlL.s.h.p.T..t..........h...p........s.....p+t..lu.thpsphtt..................................stslpG.......a.......E...hH...h.Gpohhsss.st.shhth...................................................pttsth-.........Gsh..........ss.lhGoYhHGhh.sp..................................................................................................................	1	449	934	1202
+7516	PF07686	V-set		Immunoglobulin V-set domain	Bateman A	anon	Bateman A	Domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.70	0.71	-4.19	113	19537	2012-10-03 02:52:13	2004-04-28 13:40:02	12	592	276	695	9493	120210	5	107.80	17	38.44	CHANGED	s..lpp..sp................................hpst.GpslpLpCphp...........t...tltWh+..pps........spt.phhh.........ht....thttpapsphph.tsss............ttphsLplps.lphsDsGsYhCshhs...............hhhhspsspLpV	....................................................................................................t....................................h.s.t.G.p..s.l.p...LsCphs...........................sth...t.l..t.W..hp......pps................................sp..s.....phlh...............................t..t...t.t....t..t...h....s...s.....p.....h..p..s..R.h.p...h......t.s.ts.....................................tt..s.h..s.L.p.l.ps..l.p.h..p...D.s.G..h.Y...hCth.t.....................................................................................	0	892	1878	3948
+7518	PF07688	KaiA		KaiA domain	Bateman A	anon	Bateman A	Domain	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. The overall fold of the KaiA monomer is that of a four-helix bundle, which forms a dimer in the known structure [1].	30.00	30.00	47.90	47.70	27.20	26.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.84	0.70	-5.12	3	66	2009-01-15 18:05:59	2004-04-28 17:16:04	7	1	65	14	22	79	31	249.20	44	92.72	CHANGED	LoIClaV.SsAIuQ-LpRlaouDRapLssFpSt--FCsYLEs+R-pIDCLILhaussShp.VlspLaapGsLLPAILltPpsS..AcPs-Psss.lYHsAElHLspcQL-QLPpQVDcAIAcFL+LuPlCTlPsHlhhh.ssLh-uSsps.LlsQQRRLAQKLKERLGYLGVYYKRDPu+FaRNhSPtEKQKLL--LpSpYREIVLSYFSs-usVN-pIDpFVNpAFFADluVSQVLEIHMELMDEFSK+LKLEGRSEDILLDYRLTLIDVIAHLCEMYRRSIPRE	..............................................................................h.hh.s.tl.p.htp.hL.s.p+Y.......l.......hp.s.pp..hhthlptppcplDslll..p......hhppLhppuhllPs.ll.l.t...........................................tsph.......YHssElpl..pplpplth.lDtAIspFLphu..ssthsp...ps................t.pt.........l.hpQpRLup+L+ERLGYLGVYYKR...........sPppFhRsLsssE+pcLLcpLcpsYRcIlLsYFss-tslNptIDpFVNpAFFuDlsVopllEIHMELhDEFSpQLKLEGRS--hLLDYRLsLIDllAHLCEMYRRSIP+....	0	2	14	20
+7519	PF07689	KaiB		KaiB domain	Bateman A	anon	Bateman A	Domain	The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and is found to be a dimer [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.60	0.72	-4.51	16	352	2012-10-03 14:45:55	2004-04-28 17:24:08	7	6	163	18	129	572	244	80.00	41	45.47	CHANGED	hLaVuscshsptpshpslpplppcphshpapLpllDltcQPpLsEtc+llATPsLlKlhPtPhphlsGs...pphhhhh.ch	....................+LaVuG.possShpAlpsLcp.lh-..p..c.h.t..s...Y.sLcV..I..DlhcpPpLAE.pccIlATPT.L.l.K.l.h.P.sPl+.+.IIGDLSspc+VLhsLc.h........................	0	31	86	113
+7520	PF07690	MFS_1		Major Facilitator Superfamily	Bateman A	anon	Pfam-B_5 (Release 13.0)	Family	\N	32.60	32.60	32.60	32.60	32.50	32.50	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.78	0.70	-5.74	195	181668	2012-10-03 03:33:39	2004-04-30 10:30:46	11	489	5747	5	55719	183465	25371	295.20	13	82.52	CHANGED	lhhsthhshhshth.............hhshh.......s..hh..............tpp..........................................hs........................................hs.st.....huh....lhsh...hhl..sh...slsthhh.Ghl..s-....+.h.....G..p+p.hhhhuhlhhulu..hhhh.......h.......ss......hh.h......lhhhph...ltGhst.uhhhssshshlsphhst.p.....cputsh..uhhts...shslGs.hlG.shluu....hls.thhu............aphs....Fhlhuhlslls...hl..h..hhh..............................htptstttttttttt...........................................h.hshht.........hthhhpp.........h......................hhhshhhh.....hhshhs....hhhhhsh......h.........tpthuhs.....................hhss..hslsshhshhh...thhhuhls.c+.......hst......thhhhhshhhhhhsshshhhhshs....................hhhhh...........shhl....hGh.uhuhh....hsshhshssphh....s..........pttu.....pshuhhs.hhts.lusslus	................................................................................................................................................................h.....hh..h.h.s....h.................h...s..hh..................s............hh.................................................hp.p...................................................................................h..s..................................................................................h.s.....s.t..............................h..u.h......................hhs.h..................h.hl........sh....................sl...s...t......h.........h.......h...G....h..l..........s..-...............................+..h...................G..............p..+......t.....h........h.....h.....h........u.....h....h...h......hs...ls.........hhhs.......h..............s................ss....................................................hh....h................hh..h...h...th................l.h..G......h..........u.......t........u............s........h.............h........s..........s.............s........h......s...........h.....l...........s...........p......h......h.....s....t....p...........................p..p....u.......t........s......h.........u......h.....h..t..s....................s.....h...s....l......u.........s.....h........l......u.......s..........h....l....u...u.....................h..l....h....p...h...h.u............................................................a..p...h.s......................a..h...........l......h......u..s.......l....s.l.l..s..................hl..........h.........h.hh............................................................................h..............t...........................................................................................................................................................................................................................................................................h...h...t.............................................................................................hhhhh..hh..........................................h.h.h......................................h....h.h.s..................................................................h...t.hs.................................................................................................h....h................................h.........h...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.................................................................................................................................................................................................	0	15082	30526	45126
+7521	PF07691	PA14		PA14 domain	Rigden DJ, Mello LV, Galperin MY	anon	Rigden DJ, Mello LV, Galperin MY	Domain	This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.49	0.71	-4.55	34	1994	2012-10-02 01:24:23	2004-04-30 11:44:52	7	314	720	31	924	2134	500	135.80	15	13.85	CHANGED	tpsGl.tthahpssth.s...h.................pss..sshh.stthss.shs.sphssphsGhlpsspsGpYpF..tlt......uDssscla......lsuphll-ps...stp.......................phppslthhuuphYsl+l-ahptsssthh........pltWsssssstpshstss	.........................................................................t........................................................................................................t.................................t..h...t............s.....p..a..s.h......c..hp....Gh.l.p...s.....s.p....s....G.......p......Y....p..........F..tht..........u-s..s..s...c.la.................l..s.........s...p....h..l....l-p.t............stpt.......................................................t...pt..p.ss.......l..t...l...p.sG......p..ha..tl..clpahp.ttstt...................h.h.............s..............................................................................................	0	402	643	808
+7522	PF07687	M20_dimer	Peptidase_M20; 	Peptidase dimerisation domain	Bateman A, Studholme DJ	anon	Pfam-B_253 (release 4.0)	Domain	This domain consists of 4 beta strands and two alpha helices which make up the dimerisation surface of members of the M20 family of peptidases [1]. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [2]. Family M20 are Glutamate carboxypeptidases.  Peptidase family M25 contains X-His dipeptidases.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.27	0.71	-4.33	178	25350	2009-09-11 20:10:22	2004-04-30 16:35:36	9	57	4852	83	6606	19881	6380	112.40	18	27.08	CHANGED	hup+Ghhshclp..........spGpsuHuu.hsthshN..Alp.......hhschlspLppp.................................................................sohplstlpuGt....stN....slPspspsphshR...h.stps..hcplhpplpphlppthhptp	.....................................................................................................s.ht..h..plp..........lp.G..p..s..u..H..uu...h..P..p...........t......u...h.s.....Alt...............hh.s....ph...l..s....p....l..p..s.h.....p.h...................................................................................................h.........s...s....l...s...l...s..p..l..p.u.Gs....................shN..........ll...Ps...psph.p..hslR.......sh..s..t...p.s.....hc.....tlh...p.plpphhpt.....th..........................................................................................................	1	1986	4003	5480
+7523	PF07692	Fea1	HCR1;	Low iron-inducible periplasmic protein	Merchant S, Studholme DJ	anon	Pfam-B_60541 (release 13.0)	Family	In Chlamydomonas reinhardtii, the gene encoding Swiss:Q9LD42 is induced by iron deficiency [1].  In green algae, this protein is periplasmic. The two paralogues FEA1 and FEA2 are the major proteins secreted by iron-deficient Chlamydomonas reinhardtii, and both are up-regulated in response to iron deficiency. FEA1 but not FEA2 is up-regulated by high CO2 concentration. Both FEA1 and FEA2 are secreted into the periplasmic space and genetic evidence confirms that their association with the cell is required for growth in low iron [2].	25.00	25.00	27.30	26.60	24.20	20.30	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.24	0.70	-5.63	3	23	2009-01-15 18:05:59	2004-05-04 12:51:18	6	7	9	0	20	23	61	329.40	25	55.92	CHANGED	SVLhLVlAAGAlslAsAQ.sTTGsthGGFpaAGNVIGYVNMThDYCDIQAALuAGDFTEALsIYssGKNSp+GsAp....psFh+FAoYh-ANtoGpsFaDAl.................LhsS-TahsDshlGAA.GDGD..........ATlAtGVIsVuTLKYthHEhDoAluKp....ADGNu......uDASGAPHNlDEAWAhaaGGssusCGshSuWtaS....LstAh..pGpsahGuSsuNThMlpoFlNuhcAotosuThpIpuhsAARsNphRlLsLpuLp..ushtYT-cAtsuYsccsupsshupphIAVsWshhc.MLphpsasGuuVN..slthlDFhhcpTEupLSSp...AVcsALKsVlpsLGh-sA-l..GulcucIhD-ohshcCuucTshulp	....................................................hh..............s..t..t..hs.hsGap.sosVltasphshDht-hp..A..u...lput.s.assAhphYopGtNShpupup......cThps.huoaspu..phsuEshaDsh...........................hhGp.sshhtshh.tAs.usts........................h..tslKtuhhpsshh.YshHEl--Alscs......tssss.......usssGuPHshDEuWAFYsGShp...Gssusuo.u.tth.............lstth......ttssh..sGs.o....s..ssshhhs.hpt.h..us..h.psst...th.....spspsshspllthhslshlQ..uhl..+..YthtAssu.tpsuspttt..t.....W.sa.t..shL...h...p...s.....ustst........cl.pt.s..t.uht......tlcttlcslhSshGhphupl..Gs........................hsss.shh............................	0	16	19	20
+7524	PF07693	KAP_NTPase		KAP family P-loop domain	Aravind L	anon	Aravind L	Domain	The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side [1].	20.00	18.00	20.00	18.00	19.90	17.90	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.87	0.70	-5.44	22	1164	2012-10-05 12:31:09	2004-05-14 10:44:01	9	77	813	0	383	1481	411	290.10	15	42.16	CHANGED	hs.hupplschlspss............tsshslulpGtWGsGKophlphlppthppp................................................................................................................tphhlsphssahhsst.cshhtth...hsslhpsltpchpt.ttphhhthp...........hhshhhthththhhtsshhhhh.h...............................................................................pp.ppphpthhpchtppLcp.......ptclllllD-LDRh..cspphhpllcsl+hlhph...pshsalLshDpchl...tpulpptht........supcal-Kllphshplsssshpp.lcphhtpt...hpshhpthsppth.................................................................shphshhhss.s.ts.hsPRpl+Rhlsslphhhthh	.........................................................................................................................................................t.h.p.hlt.p...............t.sh.slu..l.u..tWGsGKo.h.l.p...h...h.t..pp.h....ppt.......................................................................................................................................................................................................................................................................................................................p.hhhh....hss.h.....t......p....t........p...p...hh.th.......ht....p..l.....h........p..t..h..t..t..t........t.....................h.h..h...........................................................................h...............h...h...............................................................................................................................................................................................................................................................................................................................t.....................t...p.h.p......................h......ht...p..h...p...l.pt...................p.tlllhlDp...LD......ph.......t......p...hhphh.ph...lc.h.hhsh...................h..hh...lhs..h..c.p..l.................tsltt..t..........................s...........tahpphhph...h.l.............t......h.....................................................................................................................................................................................................................................................................h.............................................................................................................................................................................................................................................................................	2	116	190	297
+7525	PF07694	5TM-5TMR_LYT		5TMR of 5TMR-LYT	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type) [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.03	0.71	-4.92	106	2704	2012-10-03 02:46:00	2004-05-14 13:35:26	7	88	1472	0	397	1873	31	168.50	27	32.17	CHANGED	s.hFcpl.h.ppph.phtp.clhlhllFuhhuIhusahGlpl.................................s..ulsNsRslslhluGlhGGPllGlhsGlluGlaRhh..lGG..hsuhssuluolltGlluGlltthhpp......phhshhhuhhhuhhsEhhp...........hhlll......lhspPhstuhpl.......lphIulPMllsNslGsslhhhllpsh	....................................h..hFh.l.h.p.ph...ph.p.+.hh.l..hllFol.h.s.l.hu.s..a..h....Gl...lc........................s....uls.Ns...Rhl..slhhuGl.lGGP.hVG.hhs.Gll....u.G.l.a..R.ah........hGG........hs..u.l.s....s..h.....I..o..o........I..l.hG....l.l.u..G.h...l.thhhhp................chhs.hhhu...h...hl...s...h.l.sE..hlp............................Mll.l..l...................hhup...s.h.t....p...u.l.pl.............l.phI......u.h..PM...h...lss.o.lusulhhhll...p...........................................................................	0	119	232	308
+7526	PF07695	7TMR-DISM_7TM		7TM diverse intracellular signalling	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) [1].	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.86	0.71	-4.65	179	1345	2009-01-15 18:05:59	2004-05-14 13:37:09	6	102	600	0	524	1395	170	202.00	15	27.75	CHANGED	pph.hhuh.hhGhlls.hhlYNLhlahth.+-psalaYshal..hshhlhhh....s..hsGhshpal....hs......s.hhtphhhhhhhhlsh.hhsh.Fspp.a....Lph.p.t........plhphhhhhhhh..hhhhh................hh.....hthhhhhhh.....hhshlhhlhhhhhulhth..hcshpsA+aal..luahhhhlushl...hh.h........hhu..llshs.hhs..hshtl...Ghhl....chllhohALu.....+	.....................................................h..hh.uhhhGhhhh.hslas..lhlahhh..+c...p...sa...l.aauhhs..hshh.l.hhh.......s....hpG..hh..ht...hh........s...ths....h....t..p.thh....hh..hhh....hshh.hhhl..Fhtp.h.....lphpp.t............thhph.h.h.h.hh...hh..h..h.lhhlh.........................h.s.hh.........hs.hhh..hhht.............hhhhl.hh..hhhhh.hshhth......hcs..h...........ps.A..t..h.h...l.....luhh..h.hhl.s.slh.....th.hh..........hhu........hls.s.....hh....s.....hhh.h......uhhl....thlhhuhslu........................................................	0	178	351	447
+7527	PF07696	7TMR-DISMED2		7TMR-DISM extracellular 2	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins [1]. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives [1].	21.30	21.30	22.00	22.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.46	0.71	-4.75	114	945	2009-01-15 18:05:59	2004-05-14 13:41:02	6	52	497	4	371	965	86	135.70	17	17.93	CHANGED	hsl..s.tthphhcDsssphslspl..t.....t.pspFpsh........psphs.hGhspusaWl+hsL...tsssstpt.......phlLplshshL-p..lclYh......tss......thh.hhptGcp..hsasp.Rthtppshlasls.L..sssps.hshalRlpS.psshphP......lplhss	.....................................h......hphht.D.ssphs.l.spl..........ps.tapth......................psphs.huh.....s.p..s.s.....hWl+hsl.........tss.ss.p.ph.....................p.hlLpls..h...sh.lc.p..lsl...ah......tss...................s.h.p.hhphGsp...hs....hsp...Rt...ht.t....p....s...hla..ls..l........sssps..hshhl+lpo.p.t....hp.hs......l.lhp.....................................................	0	115	220	299
+7528	PF07697	7TMR-HDED		7TM-HD extracellular	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the extracellular domain of the 7TM-HD (7TM Receptors with HD hydrolase) [1].	22.60	22.60	22.80	22.70	22.40	22.00	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.20	0.70	-4.61	62	847	2009-01-15 18:05:59	2004-05-14 13:44:56	6	5	814	0	235	690	293	217.30	18	31.07	CHANGED	LpsGplA.hsIhAP+slp..DptsT-p++ppAtspl...VYshctp..hspphhpp.lpphh....splpplp...ppspt..................................................pcltph.hss...............ls-pthpp...........................................................................hh.ptsppphpphc......sslhpsl...schhs.........pslss..sthtpttp.....cs.ptpl.phtsh...sss....hptssphlsphh.lpsNhhhDtptTpphppcshpplpslh..lcpGplIV+cG-hlopcthchLchlGLlpp	...............................................................................................................................................hplu.psIhushph.......s.p...t.Tcpc+ptAtptl...s.Yt.hppp..htpp.hpt.l.p.pha.......t..l..pphp....pp.pt............................................................................tplhph.h................hh.p...lspp.htp................................................................................................................................................lh.ph...stp..php.thp...................sthhph.l..............sphhp.............................ptlpp......pphtphpp................................ch.tppl...p..sl...sst......hpp.hhpt.l..hp.h..ltsNhhhDpptTcpt+p...pshpsV..pssh..lhpGplIVccG-hlspcthphLchlthhp.p.....................................................................	0	107	187	219
+7529	PF07698	7TM-7TMR_HD		7TM receptor with intracellular HD hydrolase	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	These bacterial 7TM receptor proteins have an intracellular Pfam:PF01966.  This entry corresponds to the 7 helix transmembrane domain.  These proteins also contain an N-terminal extracellular domain.	27.50	27.50	27.60	27.60	27.20	27.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.27	0.71	-4.86	99	879	2012-10-03 04:04:29	2004-05-14 13:47:25	6	4	869	0	252	722	397	193.80	20	27.36	CHANGED	hhshlGhhlhlhlhhhhhhhahc+h.p.plhppp..ptlhhh...hlhllhlhLsph...lhh.hs.............hsalhPlsssshLlshhlssclul.....hhsslhullhuhh..........shshthhlhtlluuhsushhlp.+hppRsplhtuulhlulssh.hhhhsltl..lpsss.............h.....t..plhhpshhshhsullsu...llshGllPhhEshFsllT	............................................h...hhGhhl.hlhlhlhhhhh.ahcp.....h...p...p....phhpcp....t..lh..hh.h..hlhhlslllhph.......hhh.hp.....................hsallPhAhsslllpl.hls.p.+hul.....hs.sl.lhslhsuhh.h........shsh.phhlhtlluuhsush.hl+.c........h........ppR.sp.lhtuuh.hlulhss..lhhhslhl......lpsss......................h....s...phhhphhhuhh.sullus....llshGllPhhEphFslho............	0	121	201	235
+7530	PF07699	GCC2_GCC3		GCC2 and GCC3	He QY, Liu XH, Studholme DJ	anon	He QY, Liu XH	Family	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.24	0.72	-4.38	41	2150	2009-09-13 19:08:02	2004-05-14 13:53:13	8	312	132	0	1375	1889	98	47.60	31	7.28	CHANGED	Gpahs.....sst.....t.CpsCPtGoY.......p...spsups...pChtCPss....psT.ht..Gupshs-C	.....................G.a.t......sst........ptCt...sCPhGoY........p......sptGps......pCh.sCPss.....stT...pt...tGupshppC.....................	0	558	661	1027
+7531	PF07700	HNOB		Heme NO binding	Iyer LM, Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	The HNOB (Heme NO Binding) domain, is a predominantly alpha-helical domain and binds heme via a covalent linkage to  histidine. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce  diverse downstream signals, in both bacteria and animals.	21.10	21.10	21.10	21.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.91	0.71	-4.73	16	853	2012-10-02 19:02:47	2004-05-14 13:56:09	10	23	422	52	440	781	58	159.00	24	32.10	CHANGED	MaGhlhpslpchlpcpaGp-VW-plhcpsuh-.ppsapstp.YsDshhhcLlssluplhshshcplhchaGchhlpahhcpGaschltshucshpsFlpslDs.lHhplsphY..Pph+sPuFpspst.scssllLcYpSpR.GhhchllGll+slA+pFtp..-lplphlcppp-	..........................................MhGhl.pth.t.hl.p.p.a.G..ph.hpp.h.........hpps....t..hp......t.t..a....sht.Y.....s-.p.....hhplltsh....u.p..h.h..s.....lsh....pp..lhchaG.chhh..ph...htppt..c.hl.......psh..Gsshp-FLp.....................slDs.l.....H.p.plp..ph..a.....ss...hc......sPsFpspph...sp....s............sl..h.lcY...h...S..p..R......shtths..h..............GllcusAcphhp..clplphht....p..................................	0	159	223	352
+7532	PF07701	HNOBA		Heme NO binding associated	Iyer LM, Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	The HNOBA domain is found associated with the HNOB domain and Pfam:PF00211 in soluble cyclases and signalling proteins. The HNOB domain is predicted to function as a heme-dependent sensor for gaseous ligands, and transduce  diverse downstream signals, in both bacteria and animals.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.35	0.70	-5.13	33	958	2009-09-11 06:19:49	2004-05-14 13:58:40	9	50	126	16	637	851	5	138.40	30	19.84	CHANGED	shspchplsspsFCcsFPFHllascchplhQhGpulp+lh.........sphhhspp.......pls-hFcllRPp.lphoFcsIls+lNolFllpo.....+t............p.sp.t....p...........................................................................................................................LcLKGQMlalsEsssllFLsSPhVssL--LpppGLYlSDIPlHDAoRDllLluEQtcAphpLppchE..phpcpLcpshptL-pEKc+T-cLLYullPtsVApcL	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tlh..............pphp.......phpspL....c.......cp....p....p....tLcpE.K+KT-pLLaphlPtsVAppL.......................	0	228	292	501
+7533	PF07702	UTRA		UTRA domain	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to Pfam:PF04345 [1]. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules [1].	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.38	0.71	-4.58	168	12427	2012-10-01 19:33:20	2004-05-14 14:00:43	8	13	3138	54	2128	7191	599	138.40	19	57.50	CHANGED	spGtp.spsc....llphphhsu..sspluptLsl.sssst.VhclpRlRhh...-spPlsl-psalstp.hhssht.....pp.ph......ppS..laphLcp..hsh...tlsp..uppplp.Aths.sscpuphLsl...sss..sslL..hlc+hsasps..upsl-aspshapu-cac	......................................................Ghpspop..llp.hph.h.....s....s..t..plup...t...L...s.....l...p.....s.p...p......l..h.pl.p..Rl..Rhh..........-s...p....P....h..h....l.......-..ps..al...s.....h...p...h..h..s..s..ls...........pp..th............ppS...l..a.ph.lcp....hsh...pls.p......up.p...p...lp..sh...h.s....ss.....c.....u.p....h....L..p.l......sts....p.P..lL...hlc.ph.s...a...s..p.s....upsl-aspshaps-ta...............................................	0	564	1212	1689
+7534	PF07703	A2M_N_2		Alpha-2-macroglobulin family N-terminal region	Studholme DJ	anon	Prosite	Family	This family includes a region of the alpha-2-macroglobulin family.	21.50	21.50	21.50	21.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.86	0.71	-4.37	184	2785	2009-01-15 18:05:59	2004-05-14 15:54:42	9	133	1371	58	856	2463	101	141.90	22	9.28	CHANGED	lpl...phsc..pshpsG-shplplp..sshs................up.hhhhl.h.pspllptt............................................................thp.hpssps.......................................slplslspchsP.sshlssh.hl.............................................s....hshsss.hlsVpp.sp...phplplps.s....p.phpPspphplplp..s.....................suhlslsAVDpulLtL	.....................................................................................................................................................plthsp.sthpsG-s..hplplpsshs................sp.hhhhl....s.ps.pll.h.hp............................................................................hhc...ls..spth...............................................................slplsls.p..s..h..sP..shhls..sh..hl............................................h...sphshssh.tl.slp..s...sh...ph.s.l.p.lps..s.............s..ph....pPs....p.p........ls..lclp.s.................s.suhlsl.suVDpulL.l.............................	0	194	349	599
+7535	PF07704	PSK_trans_fac		Rv0623-like transcription factor	Anantharaman V, Aravind L, Studholme DJ	anon	[1]	Domain	This entry represents the Rv0623-like (Swiss:P96913) family of transcription factors associated with the PSK operon [1].	28.30	28.30	28.50	28.40	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.61	0.72	-3.30	29	347	2012-10-02 18:44:02	2004-05-17 11:25:38	6	1	139	0	81	156	29	81.60	36	96.75	CHANGED	Mu.LsIKsscscpLA+clAchTGp.ohTpAlppAlcccLp......ccppptshh..-cltsl.....hpttthshhss.psscpphhaDEhshss	.........Mu..LsIKsscscpLsccLA.tcsGp.ohTpAVtsAl...pcc.Lu...........ttppcpssLt..-cLtsl.....hcptuhssscs.ttscphh...hYD-pGLPt...............................	0	20	42	63
+7536	PF07705	CARDB	DUF1604; APHP; 	CARDB	He QY, Liu XH, Studholme DJ	anon	He QY, Liu XH	Domain	Cell adhesion related domain found in bacteria.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.20	0.72	-3.96	72	1259	2012-10-03 16:25:20	2004-05-17 11:57:42	6	225	338	5	749	1464	732	105.20	19	17.15	CHANGED	tP...DLhl.........thssssshsspp.slss.s.lpNpGsss.usshplp.........lYlsus.h...sshsl...........suLsuGsspslshshhs....ps........Gshs.lpsslDssNtlsE.sN...EsNNphot	...................................sDLhl.........t.hhssss..s..t.s.G..p.s..hsl..ss...s..V.pN..p.G.....s.ss.....u..s..s.....h.p....l.p........................l..h...l...s.ssts..................sstsl................................ssL...s.s.G..p.......o.....t......s.....l....s..hshsss............ss....................................G.s.ap..lt..s...h.s...D.s.......t....s.........t......l.......E....s.....c..sNN....s........................................................................	0	244	406	657
+7537	PF07706	TAT_ubiq		Aminotransferase ubiquitination site	Hargrove J, Studholme DJ	anon	Pfam-B_15367 (release 13.0)	Motif	This segment contains a probable site of ubiquitination that ensures rapid  degradation of tyrosine aminotransferase in rats.  The half life of the enzyme  in vivo is about  2-4 hours. In addition, unpublished information identifies at least 2 phosphorylation  sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at  S*QEECDK. This region of TAT is probably primarily related to regulatory events.   Most other transaminases are much more stable and are not phosphorylated.	18.90	18.90	18.90	22.20	18.40	17.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.31	0.72	-7.87	0.72	-4.02	7	51	2009-01-15 18:05:59	2004-05-24 12:14:22	7	3	35	0	25	44	0	41.20	55	9.12	CHANGED	hcsYlIQMsususL.......PolLDsHVNlsGhsoV........uKhKuRKsR	.MDsYVIQMsusGsL.......PSlLDVHVNluGRSSV.......sGKhKGRKAR..	0	1	1	7
+7538	PF07707	BACK		BTB And C-terminal Kelch	Stogios PJ, Studholme DJ, Finn RD	anon	Stogios PJ	Domain	This domain is found associated with Pfam:PF00651 and Pfam:PF01344 [1]. The BACK domain is found juxtaposed to the BTB domain; they are  separated by as little as two residues [1].  This family appears to be closely related to the BTB domain (Finn RD, personal observation).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.15	0.72	-4.18	81	5713	2012-10-02 01:20:04	2004-05-27 16:12:29	10	234	772	7	3017	5073	29	98.70	24	18.96	CHANGED	ClulhpaA-ta.sspcLhphuppaltppFhpVhps-.-Fhp.LshcplhpllssDcLslpsEcpVapAlhpWlpa-hppRppthsclL.ppVRl.sLlsspaLhphlp	......................................Clthhthu.c.ha....st.p.cLt..p.tshp.....a..l...hpp.F...p....l......h.....p.......s....-......-..........F....hp....L...s....h....ppl...h..p.l...Ls..p.-p......L.....p..l........p.....s......E.....pp.............l.ac..Asl...p.W.........l....p..............t..........c..............h...........p..........p............R.........p.........p.........h...........h........s.............p.............l....l....pt..lRh..shls.thLhp...............................................	0	922	1157	1963
+7539	PF07708	Tash_PEST		Tash protein PEST motif	Yeats C	anon	Yeats C	Motif	This motif is found in the Tash AT-hook proteins of Theileria annulata. These proteins are transported to the hosts nucleus and are likely to be involved in pathogenesis [1]. It is also often found in conjunction with Pfam:PF04385. It is suggested that they may be 'part of PEST motifs' (a signal for rapid proteolytic degradation) in [2],  though this is not definite. This motif is also found in other T. annulata proteins, which have no other known domains in (unpublished data: C Yeats).	22.40	22.40	22.40	22.40	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.33	0.73	-6.32	0.73	-3.83	11	113	2009-01-15 18:05:59	2004-05-28 10:38:50	6	10	2	0	52	114	0	18.70	62	4.55	CHANGED	E-L-PETIplElpSD-E-p	...pLcPETIPVEluSDEE-...	0	0	47	47
+7540	PF07709	SRR		Seven Residue Repeat	Yeats C	anon	Yeats C	Repeat	Associated with Pfam:PF02969 in  This repeat is found in some Plasmodium and Theileria proteins.	19.50	2.30	19.70	2.90	18.70	-999999.99	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-6.43	0.77	-6.36	0.77	-2.75	14	54	2009-09-16 13:37:02	2004-05-28 11:45:45	6	9	8	0	38	51	9	13.60	30	9.06	CHANGED	pphccVcssYppLp	..ppacpVpssYpplp...	0	12	31	34
+7541	PF07710	P53_tetramer		P53 tetramerisation motif	Bateman A	anon	Pfam-B_782 (release 3.0)	Motif	\N	20.70	20.70	20.90	21.10	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.89	0.72	-4.86	28	335	2009-09-11 15:49:44	2004-06-01 14:29:59	6	11	99	129	105	383	0	42.20	46	9.30	CHANGED	KK++s....tDcEhFTLplRGREpYEhLpKlp-uLELt-hh.sppps	.............K++s............D-E.h.....ahL..plRGREp...aEhLhKlpEuLELh-hl.sppp.h........	1	12	18	42
+7542	PF07711	RabGGT_insert		Rab geranylgeranyl transferase alpha-subunit, insert domain 	Finn RD, Bateman A	anon	Pfam-B_20675 (release 13.0) 	Domain	Rab geranylgeranyl transferase (RabGGT) catalyses the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking [1].  This domain is inserted between Pfam:PF01239 repeats.  This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP [1].	21.10	21.10	21.40	22.30	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.45	0.72	-4.19	4	58	2009-01-15 18:05:59	2004-06-02 17:26:25	6	16	37	3	24	51	0	98.50	59	19.56	CHANGED	-hIpCVaVSR-EupVoVuFS+PVts..tpssLlLhLDspP.tVpWRoscsR.++S.lWlCDLPssuIsDpsspHshpVhWT-tcs++-CsLYsGppEsWCRDSA	.............-uLRCLHVSR-EACLoVuFSRPllVu.sts-sLLLhVD-SPLhVEWRTPDGRNRPS.HV..WLCDLPAuSLNDphPQH.oFpVlWTuu-spKECVLhpGRpEuWCRDS....................	0	2	4	10
+7543	PF07712	SURNod19		Stress up-regulated Nod 19	Studholme DJ	anon	Pfam-B032880 release 13.0	Domain	\N	25.00	25.00	27.90	29.40	21.30	23.20	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.28	0.70	-6.02	3	106	2009-01-15 18:05:59	2004-06-03 14:42:03	7	3	29	0	66	84	1	309.50	44	88.67	CHANGED	FLKTEc+IKSAVFaSPKlELuPGSVSN+aYYDIDFPRGHIuLKuFsAEVVDEAG+PIPLHETYLHHWlVVRYHQsKsScpsppphF....................IaVRNuGlCQusoLGQYFGLGSETRGTuTYIPDPYGIEIGNPEEIP-GYEEKWLlNIHAIDTRGVEDKpGCIECKCDLYNVTlDEYGRuIRPsYKGGLhCCYDpTQCKLKcGF.pGPK.RSLYLKYTV+WVDWDcYllPVKIYIFDVTDTLKlSD+SKGsss-HsCKlEYEVEPCsTNshpcsGCVDVKKsSLPMQsGGYVIYGVAHQHSGGIGSTLYGQDGRVICoSIPKYGNGcEAGNEsGYIVGMSTCYP.PGSVKIhDGETLTLESNYSNslcHTGVMGLFYlLVAEQLP.Pcl	................................................................................................................................................................lpotsFhSsth.hsPGplss+hhhslcFP+GHlulKuFsuElV..D...p..tG..s....slPLaETYLHHWhh.t..Ya...h...s......p.....................t...h......................hhh+NpGhCptthl.pa.aGhGuEoRtTso.lPsPaulEhGNPtths..p.GY-E+WllNlhsIDTRG.s...D+..huChEC+C.......D..............h.......YNV.ThD..............sp..............lp....................sY+GGLhCC.DthpCph.pp...GF......pu....p....Rplh.L+YslpWl-Ws.p.h..lPl.+..lYIhDsT...Dp.......ps.p................psCp.......hEYp...l..t.sssst....s..s.csppsp.hsh..................pGG..................llYGsuH.HsG........shsuoLaG.p.................DG.RhlC.....sShP......pYG.....sG.pEuGNEtGYlVGMSsCYPp...PG...ol.+ltcGEhLsl.opYss.p..t.pTGVMGhFYlhlA-......t.................	0	7	58	64
+7544	PF07713	DUF1604		Protein of unknown function (DUF1604)	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of several eukaryotic RNA processing proteins (e.g Swiss:Q8N3B7).	25.00	25.00	25.30	25.30	20.00	19.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-9.96	0.72	-4.19	20	248	2009-01-15 18:05:59	2004-06-03 14:42:41	8	7	214	0	185	248	1	86.30	55	10.82	CHANGED	pchlPlacQpVpDEcGR.+RFHGAFTGGFSAGYaNTVGSKEG....WsPpTFpSSRppRus....sp..sppsEDFMDEEDlu-ht.tspplpoppcF..s	............p.p.lPlhcQpV+DEcGR.+RFHGAFTGGFSAG.........YFNTVGSKEG...............WTPoTFsSSRpsRAc............pp......pp+PEDFMDEEDluEht...ts+plpTsspF............	0	70	105	150
+7545	PF07714	Pkinase_Tyr		Protein tyrosine kinase	Studhome DJ	anon	Unknown	Domain	\N	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.54	0.70	-5.32	145	24806	2012-10-02 22:05:25	2004-06-11 14:25:16	12	1823	1048	846	13827	124495	4199	232.30	26	33.84	CHANGED	lpht.cpLGpGsFGpVacGphp...................ttsphpVAVKsL..+...p..sssppt...hpcFlp.EuplMppl.pH.plVpLhGlss...........ptpP.....hhllhEahptG...sLhsaL+pp..................................................................................................ptplshtp.LlphuhQlApGMpYLps+p..hlHRDLAARNlLls.....c.............st.hlKIuDFGLuRtl.........pps.Y..ptpssuc..hPl+Wh...APEulptsp..........aospSDVWSFGVlLWElhohGp.pP..............Yssh.ssp-........lhphl.cpGhR..hsp.PptCPsclY.pl.MtpCWptcPppRPoFppl...hptL	...............................................................................................................................................................................................................................p.lG..p....G....t.F..G....t...V..h..t...u....h.................................................t.h........V.......A.......l.........K..........h..........l.........p...................t....................t...t............t............t..........t................................................p...........p...................F.........h.................p...........E.................h...........p...........h..............h.................p.............p................l................p...................H.............................N...............l...............l...............p...................l............h.................G.....h....sh.................pt.t.......................................h.h..l...l......h........E........a........h........t....t....G.................s...L....t......p......a......L....p...p..p.......................................................................................................................................................................................................................................................t..t.........l....s.....h.....t....p.......h....l........p.....h.....s.......h....p.........l...........A..........p..........G....h........t...........Y..........L.........c.................p.................p..........p...................h...........l.............H...............R................D.........L..............t...........u..............p...........N...........l......L......l...s....p........................................................sh....h....s.....K......l......u.......D.......F.....G.........l...u......+..h...........................................t....t......h...................h....t......t.......t...........s........h.........h.............s........h................t...............a......h..................A.....P.........E........h....h.........t..t.h.........................................h....o.....t......p......o.........D.....V.........a.................S..............F.............G...............l....l.........l..........h......E..........l.............h......o..................s.....t........P.....................................................a............t........h......p.......t.....t....p...........................h....h.....t........h........l..........p..........p.........s............h........p....................h...................h...........s................................t...........s...........s.............................t..............h..........h.............p........l..........h..............h........t.......C.............h.......p.............p..s...p...p...R.P..s.htplht.......................................................................................................................................................................	1	4020	7259	10608
+7546	PF07715	Plug		TonB-dependent Receptor Plug Domain	Yeats C	anon	Yeats C	Domain	The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors ([1]). It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.23	0.72	-3.72	742	36469	2012-10-03 10:59:06	2004-06-15 15:23:27	10	123	2367	66	9642	33866	11001	109.70	22	13.45	CHANGED	shpssstulss......lstcp.lppp..s.sssls-sLp......t..hP......Glsh.........................sssssss...s.....s..sh...........slRGh.....ss....................spshlhlD.Gh.h..............................tts...........shs..t..l.s.....s.....t..sl-plEVl+.Gssos.lYGs.suhGGl	...................................................................................................t...phstslss.....l.s.t.c..p...l.ppp....s...ss..s...l...s..-..s.Lp...................t...hP...........Glsh.................................ssss.sss....s...........s....pl.................plR...Gh.....ss...................................sps.hlhlD...G.l.h...............................................tts.................shs....t..l.....s........s.......s..sl.-..p.l-Vl+..G...s.s..u.s..lY.G.s...s.uhuGs............................................	0	3204	6758	8441
+7547	PF07716	bZIP_2		Basic region leucine zipper	Studholme DJ	anon	PfamB-200; Release 14.0;	Family	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.57	0.72	-4.14	48	1966	2012-10-02 13:17:30	2004-06-16 18:28:29	10	24	376	25	1196	6475	28	53.70	29	17.49	CHANGED	pssphpp+Rc.+NNtAu++SR-+++t+ppphpp+ltpLpccNppL...cpclppLcpE	.................pphtt+.R....c..+N.s...A..A++SR-+++...h+p..p.......p...l.......p...p.......c.......l....tp.......Lp...p-.Np.pL..........cpclttLpt..........................................	0	353	569	934
+7548	PF07717	OB_NTP_bind	DUF1605;	Oligonucleotide/oligosaccharide-binding (OB)-fold	Yeats C	anon	Yeats C	Domain	This family is found towards the C-terminus of the DEAD-box helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. There do seem to be a couple of instances where it occurs by itself - e.g. Swiss:Q84VZ2. The structure PDB:3i4u adopts an OB-fold. helicases (Pfam:PF00270). In these helicases it is apparently always found in association with Pfam:PF04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins [1].	21.40	21.40	21.50	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.61	0.71	-4.25	118	5209	2012-10-03 20:18:03	2004-06-21 13:22:17	11	143	2032	5	2747	4906	191	134.10	22	12.53	CHANGED	pQLtplh...................................................pch...phph..........p.........................................................pp.phl+pslsuGha.plA.....................................thp............pp.....sp..Ypsh................................tpsp.hlhlHP.uSs...l...........hppps.c.....................allapEllp.............T........s+..ah+s........................sotl.pspWLhth.u...sph	...........................................................................................................................................t.QL.thh.................................tphth...p.....................................................................................................................................sshptl+pulhu.Gh.hs.plu...................................................php...........................pp...tp...Yhss.............................................csp....phhlHP..u..Ss.....L..........................hcp..t.P.c....................................................a..llatElVp.......................T..............................o+...ha..h..R.s.............................sstl..cPpWl..l..usp.......................................................................	0	873	1456	2200
+7549	PF07718	Coatamer_beta_C	DUF1606; 	Coatomer beta C-terminal region	Yeats C	anon	Yeats C	Domain	This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). This C-terminal domain probably adapts the function of the N-terminal Pfam:PF01602 domain. 	25.00	25.00	36.20	30.30	23.60	22.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.55	0.71	-4.53	25	351	2012-10-03 16:25:20	2004-06-21 13:22:31	7	9	301	0	255	354	8	138.40	49	15.21	CHANGED	QsDDhIsF+QLpu+putsssp...sh-sDLs+AT.G.sssspp.chs...p.....+Ls+VhQLTGFSDPVYAEAYVsV+QYDIlLDVLlVNpTs-TLQNLolELATlGDLKLVERPpshTLuPtsFpsI+AsIKVSSTETGVIFGsIVY-ssu	..................................................................QsDDsIsFtQLstcssh..s..stc.............thp.sLtt.Ah.G......ssppp.p.shs..............SKLs+.V..sQLTGFSDPVYAEAYVpVpQaDI................VLDVLlVNQTs-TLQNlolEhAT.LGD..LK.lVE+P.....s.shs.LuP+-Ftslc.................AslKVoST-sGVIFGNIVYDsss...........	0	90	147	213
+7550	PF07719	TPR_2		Tetratricopeptide repeat	Studholme DJ	anon	Context matches from Pfam 14.0	Repeat	This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by Pfam:PF00515.	27.00	13.00	27.00	13.00	26.90	12.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.73	0.74	-7.75	0.74	-3.60	369	18395	2012-10-11 20:01:00	2004-06-21 18:10:22	12	4257	3733	24	7965	120483	33152	32.50	19	6.62	CHANGED	spshhthutshhptsch.pcAhptapcAlplssss	.........................hhhthGt.h.h.h..p.t..s..c...h..p...cAhp...h.appAlpht..................	0	3026	4971	6601
+7551	PF07720	TPR_3		Tetratricopeptide repeat	Studholme DJ	anon	[1]	Repeat	This Pfam entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones [1].	20.70	11.00	20.70	11.00	20.60	10.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.19	0.72	-7.60	0.72	-4.11	18	1102	2012-10-11 20:01:00	2004-06-22 13:19:31	7	26	538	52	97	1589	293	33.40	29	26.08	CHANGED	h-hlauh...AtshatptcappAhph....hhshlptps	................h-hlhua.............Ahshpp.p.tchpcAtsh..at..hhhhhsh.s..............	0	34	50	73
+7552	PF07721	TPR_4		Tetratricopeptide repeat	Studholme DJ	anon	Manual	Repeat	This Pfam entry includes tetratricopeptide-like repeats not detected by the Pfam:PF00515, Pfam:PF07719 and Pfam:PF07720 models.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.82	0.74	-7.35	0.74	-2.96	143	472	2012-10-11 20:01:00	2004-06-22 16:56:25	9	256	297	0	244	3990	1150	25.00	25	5.32	CHANGED	ststhshApshhttGchspAtshlcp	..........hhhsLAtshhtpGchspApphhc..........	0	84	180	210
+7553	PF07722	Peptidase_C26		Peptidase C26	Studholme DJ	anon	MEROPS	Domain	These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to Pfam:PF00117, but contain extensions in four loops and at the C terminus [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.30	0.70	-4.90	45	3232	2012-10-03 00:28:14	2004-06-23 11:09:18	8	15	2292	12	825	18376	10620	205.10	31	78.01	CHANGED	PlIGlsusht..htttshtshst.pYltuth.pulptAGGlPlllPht..sspshpphlstlDGllloGGt.sVcPphYutpsp.tpss.hsssRDthclsLlctAlppshPlLGICRGhQhlNVAlGGoLaQclpt....t..thht........p......htssHslplp........uohLuplh.....s..sc...hpVNShH+Qulcc........LussLpVpApus.DGllEAlps.stp.hFslGVQWHPE	................................................................................................llG.lss.s.............................................t.......t....h.........pa.ls..tthhphl.t.t.u..GG.l.Pl...l...l..........P.......h........s.................s...........p.......h.......h....p.....p...hl...p..h..l..D..GllL...sG...Gt.sV....p...P..p...h...Y........G.................p..p..................................t........................p................t........s................s......h.....s.......t........R.......Dth...-...l.s.L...l.c...t....A...l.c...p.......p.......hP...lh..uICRG.hQ..l...........l...N........V.....A.......h...G...G..o..L...a..Q..c....lp..p...........t......h.....t...p.hp.p.......................................p.................hs..s..H.p...l...p.l.p..............................................ts...o...h...L.t..p.lh.......................................s....pp.....h.h.V..N...S...h..H..+...Q..u..l..c.p.........................l.u..s..s..L...c...l...p...A...h............u..........s......D.....G......l......l......E...A.....l.....p.....s.......h....s.....t....t......hhl.GVQWHPE....................................................................................................................	0	299	509	675
+7554	PF07723	LRR_2		Leucine Rich Repeat	Studholme DJ	anon	PfamB-152 (release 14.0)	Repeat	This Pfam entry includes some LRRs that fail to be detected with the Pfam:PF00560 model.	20.90	9.50	20.90	9.60	20.80	9.40	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.64	0.73	-7.26	0.73	-3.24	161	389	2012-10-02 21:32:02	2004-06-23 16:09:48	8	33	40	0	269	479	1	25.70	36	6.48	CHANGED	sLKsLpL.pp...lta....ssctslppLlSuCP	...........sLKoLpL.pp...Vpa.......ssctslppLlSuCP........	0	142	155	160
+7555	PF07724	AAA_2		AAA domain (Cdc48 subfamily)	Studholme DJ	anon	PfamB-40 (Release 14.0)	Domain	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.94	0.71	-4.35	139	20963	2012-10-05 12:31:09	2004-06-23 17:05:00	9	82	5116	83	4876	26856	10382	171.50	36	26.68	CHANGED	cPhushlhhGPTGsGKTp.........Lu+sLAphLh..............spppshhphDMSEahE........c+slu+LlGussGYVGh-puG.Lo-tl....tppPasllLlDEIEKAcs...............sV.phLLQll-suplo.........-spG.ppVch+NsllIhToNhuupthtp........................................hpt.h.t.lpthahP.EFlsRls.h	.........................................................................................................................................hushl.hlGPTG..s.G.KTc...........................LAc.sL.AchLh....................................................................................................................................t.tpsh..hp..h.......D..h....o....E.ahE...................................c....p...s.......l.......s.....+...L...l...G...u.......s.........s.....G.......h......V.......u...h.......-..c...sG...................................................tllllDE..I-...Kups........................................s....V........p......h.LL...p.ll...-....s....u...p..lo.........................................................................D.sp.G....hpV...D..h.....c..N....s..l.h.I.h.Tu.N..huutp..h.p....h...........................................................................................................t.t...hp.ts...p.....l.p....h.h.....h.....P.........EFlsRls............................................................................................................................................................	2	1633	3130	4111
+7556	PF07726	AAA_3		ATPase family associated with various cellular activities (AAA)	Studholme DJ	anon	PfamB-40 (Release 14.0)	Family	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.70	0.71	-4.54	55	4128	2012-10-05 12:31:09	2004-06-24 10:26:01	6	8	2112	1	1431	6260	2158	130.60	58	39.23	CHANGED	HlLlEGVPGluKThls+sLApslshsFpRIQ.FTPDLLPuDlhGo.plactcs....ppFcFctGPlFusllLADEINRAPPKTQSALLEAMpE.+QVTlsGpTasLPcPFhVlATQNPlEpEGTYPLPEAQLDRFlh	....................................................................................HlLLEsVPGluKThh...s+...sL...A....p.s...l.....s.......h.............s..............F...p....R....I...Q....F.....T...P.....D..L.........L...P...u........D.....l....s..G........s......p......l....a...s..t..ps...................t.p..F......c......F........c..........G....P.......l......F............s........N...........l...........l.....L..A.........DEINR.....A.....s....P.....K....T.....Q.....S...A...L...L...E..A..M.....p.....E..+.....Q.....V......T.....l......s.....G....p.....T.....a.....s...L...P.....p.....P...F.....h.V...l.A.T.Q.N.P..l.......E.......p.......E........G.T.Y......P.LPEA..QLDRFlh.....................................................................................	0	512	1017	1260
+7557	PF07727	RVT_2		Reverse transcriptase (RNA-dependent DNA polymerase)	Studholme DJ, Eddy SR	anon	PfamB-40 (Release 14.0)	Family	A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses. This Pfam entry includes reverse transcriptases not recognised by the Pfam:PF00078 model.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.61	0.70	-5.41	99	7027	2012-10-02 12:54:00	2004-06-24 14:06:22	9	498	350	0	1834	6948	486	136.70	27	23.93	CHANGED	NpTWcLVshPpsp.+slGsKWVF+hKhsscG.slpRaKARLVA+GasQppGlDYp..ETFuPVs+hsolRhlLulAuppsaplcQhDV+oAFLpG-LcE-..lYMpQP.GF.spsp......sspVC+LcKuLYGLKQAPRtWap+hsshLhphGFpputsDssla..h+ppsssh.lhlllYVDDlllsusspphlpphKppLspcFcM+DLGthpaaLGlElp+..sspGlhLoQppYspcl.LpchsMpss+..PssoPhsss	........................................................................................................................................................................................................................................................................s.salp..u.....l...p..-..p....l..ah.....t.......P..uh.................................t..hh.h..h.L.......+u.lYG......L+.Q.......u.s....t....W.....p.h...t..t.h.h.....t....th..s......p........s.h....a....h..............t....t................h..hl.hl......aVDD.h...........................................................................................................................................................................................................................................................................................................	1	611	910	1250
+7558	PF07728	AAA_5		AAA domain (dynein-related subfamily)	Studholme DJ	anon	PfamB-136 (Release 14.0)	Domain	This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.54	0.71	-4.45	34	10563	2012-10-05 12:31:09	2004-06-29 09:05:52	9	237	3591	15	4659	65399	18925	134.50	18	14.25	CHANGED	sllLlGsPGsuKohlsppluttl.....spshhhl.hspshots-lhtthph.......ssttthhsuslhpAsp..........cuplshl-Els+sp.sslhssLhslLsc+phhh.pssthhtst...........................hpllusuNshs.......hthsphssALtpRF	..................................................................lhlhG....sGs....GKo...t.....l...s..c......t..l....u..thh............................st..........h......h....h.......l..............h.......s........t..........t..........h.......s................p......c....l.........h...G...t...h....s...............................t..p..h..t....h...p....s...u.......l...h..p..s.hp...................................................................................ps..h....l....l....h....l..D.E.l..........s...........h.............s.............t.....s..........p..............h..........h.......s......s..........L......s....l....l.......c....p....p....p.....h....h....h.......t...t.....s....t......h...t..h.................................................................................................hhl..l.s.s.h.N.sht..................h..t..uhhpR......................................................................................................................................................	1	1765	2764	3880
+7559	PF07729	FCD		FCD domain	Bateman A	anon	Pfam-B_117 (release 14.0)	Domain	This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain Pfam:PF00392. This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical [1]. This family has been named as FCD for (FadR C-terminal Domain).	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.55	0.71	-3.80	317	20783	2012-10-01 22:11:53	2004-06-29 14:06:45	7	44	3128	16	5347	14681	1573	125.20	20	52.31	CHANGED	-...l...h...ph...RthLE.....stss.p..hAs..pphss...........pplpplpphh.......pphppshp.....tsch.t.............hhphctpFHttlhptusNthlt...........p..hhppltttht.h..hhthth................stpphppshpc..Hp.pllcAlts.pDsctAtph........hppH.lpt	........................................................................plh.ph...RthlE......stss...p....hAA....tp..t.os.........................pp.l.t.p..l.pphh.............p.p...h..p..p..s.hp...........................ttc.htt...............................................hhp..h.-..hpFHt.tlh.p.s.ut..N..h.Lh................p...hh.p.p.l.hshhp..t.......hhthhht............................ptpt.h.p.p...h..hpp......Hp.tIlcA.l..t.p.p.D.s...c.t..A.pps...........hppHlt.t....................................................	0	1367	3132	4302
+7560	PF07730	HisKA_3		Histidine kinase	Studholme DJ	anon	BLAST	Domain	This is the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with Pfam:PF00512 and Pfam:PF07536.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.27	0.72	-3.63	191	12598	2012-10-11 19:05:54	2004-06-29 14:17:48	8	320	3309	15	3406	10118	555	67.60	26	14.71	CHANGED	ERpRIARELHDsluppLsslthphphhpthh.....ppsst...........psppplpplpphsppuls-lRplltsLR..sssh	.............................ERpRlARELHDslup..pLssl.p.hp.h...p..h.hpphh.......ppsst.............................psp.ptlpplpphsppuh...pcl.RplltsLR.s.....................................................	0	1258	2513	3067
+7561	PF07731	Cu-oxidase_2		Multicopper oxidase	Studholme DJ	anon	PfamB-49 (Release 14.0)	Domain	This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.81	0.71	-4.67	127	6906	2012-10-02 17:41:00	2004-06-29 16:37:37	9	88	2541	150	2712	7112	437	134.00	20	24.40	CHANGED	ths.pssshhph................................t...hhssspshslphsshlclhh.s........s.............................sHPhHLHGasFhllspssssh............................sh.ssspRDTltlss....suhssltaps...D.NPGsWhhHCHlt..hHhstGhhhhhh.tsts	.........................................................................................................................th....................................................t.t....h.sstph..h..t.l..p....h....s...p...h.h.c.h..h..h..s...........s.h...................................sHP.hHl...HG..h.p...F.p..l..l..sp.....ss.s..................................................................................p..s..s.h.+D..T..l..t......l....s...................ssh...s..tlthph......................-..ss.........G....s.Whh......H......C.................H.....lh........H..hs.......t..Ghhh.hhh....t....................................	0	653	1565	2232
+7562	PF07732	Cu-oxidase_3		Multicopper oxidase	Studholme DJ	anon	PfamB-43 (Release 14.0)	Domain	This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.50	0.71	-4.37	121	9918	2012-10-02 17:41:00	2004-06-30 09:10:05	10	110	3033	407	3010	9791	561	100.50	30	22.68	CHANGED	plphsshshhsts...ppshslNGphPGPslpsppGDplhlpVhNpl...sps.solHWHGlpphtssh.DGssulTpCPItP.GpsasYpFplpp..tGThWYHuHhsh...p...sGlaGslllpspts	...................................................h..................hhhh.s.....s...t.....h.........G....P......h....l......php...............G........-t.l.............lph....h.....N..............ph..........s..................p....................s.......h............o....l..............HW.................H........G.....l............h...............h...........s............s.............................D...........G..........s........s..................t....................h............s...........p............s..........s..............I.......t.......P..........G.........p.........s.........a....s....Y..p...F........p.....s........p.........p......................s.........G.........T............a..........W.........YHuH..t...............p.h..tGl.hG..hllps...................................................................	0	695	1662	2404
+7563	PF07733	DNA_pol3_alpha		Bacterial DNA polymerase III alpha subunit	Studholme DJ	anon	Pfam-B111 (Release 14.0)	Family	\N	22.00	22.00	23.70	22.40	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.23	0.70	-6.04	89	7657	2009-01-15 18:05:59	2004-07-01 10:32:47	7	67	4508	9	1594	6277	5227	405.60	35	36.47	CHANGED	phLpchshpGl..ccRh.................................h.pRLchELslItph......GFssYFLIVtDhlpaA+p....pGI.VGsGRGSuAGSLVAYsLsIT-lDPlp...........................................asLLFERFLs.ERsshPDIDlDFspc+RpcVIpYVtc+YGc......-pVAplsTauThtuKuAlRDVuRsh.......shs.s.hstlsKhls.........sh............ptshp.p........phpphht.p..........phpclhclAppl...-GlsRpsupHAuGlVI.usp.sLs-hsPlhhssps..........................tthlTQa-hcs.lEshGLlKhDhLGLcsLThIcpshchlp.................tp.......tth............h.....s............l..tsIP..h-Dt.psac.hlspu................cThGlFQlESpuhpshLpcl+PssFpDllshsALhRPGPhp.......t.lpsalpR+pG......ptlpa.ps.........lc.lLppTaGlllYQEQlMplu..phhAGaohGcADhLRRAMuK.Kc.p.htc.+p.....pFhpGhhcpu	................................................................t..LtchshpGh..cc+h...........st......tt...................................................hpcRL-hELslItph........GFs.sYFLIVh-hlpau+s...........................p.Gl...V.G.sGRG.SuAGSlVAYsLtIT-.lDPlp.....................................................................................................a.sLL.F..ERFLNsE......R....s......shP.DIDlDF.s.t..........c.p.....RscVIpYV.tcpY...G..c........-.pV..uplhThGTh.tu.......K.ssl+.DVu+sh...............sh.s.t.hstl..s+h.ls.t...............sl...................tthht.p.........................................ph..t..p..h..h..t...t.p...........................................cspclhchAptl...-.G.lsRpsuhHu........uGlll..ssp.s.......lh-hsPl.hssps.............................th.lTQ.a.-hps..lE......t.hGLlKhDhLGLcsLThIchshchlp............................................................tp....................t...........h.....s.....................l...pp..I..P..........h-.Dt...p.......s...ap..hhppu.....................pThGlF..QhE.S.puh+phLc..c.h...........+...Ps...........s..........Fp....Dllsl....s...uLhRPGPhp.......s..lps....al.cR+pu...............p........l......p.h.ps.................lc.lLt.....p....ThGlllYQEQlMplu..t..hhuGaohGtAD.hLRRAMuK..K....p.....p...h.tc.....+p...tFhpGhhpp.....................................................................................	1	562	1068	1361
+7564	PF07734	FBA_1	DUF1607; 	F-box associated	Studholme DJ	anon	Pfam-B128 (Release 14.0)	Family	Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.44	0.71	-4.55	99	950	2012-10-01 23:07:08	2004-07-01 11:05:26	8	29	37	0	484	1107	0	142.20	20	39.04	CHANGED	uVSLKGNTYWhAp.........ccppt.......................a.llsFDFosE+...Ft.shlsL..Paptt..............sshsLS.sVR.-E.+LulL..hQ.......ptpo.p......hEIWlTs.K..I-ss......sVSW..spF.Lpls.hpsh......sth.............ssSFF.lDE....-K.Klsls..hc...pptppt..............shhYIl.G.cs...thhpcls.......................hhPhhh..s.YVPS	..............................................................l.lpGshYWhup.........cppp....................................................h.llsFDh.s.s.Ep...F..t.h..l...L..P.hptp...................thphhsL....h.ht....p-..pLs.hh....hp............p.p..s..p.......h-IWlhs..c....hcss......psSW.....oKh..h...sls..h..h......................................h...................................................................................................................................................................................................................	1	160	208	232
+7565	PF07735	FBA_2		F-box associated	Studholme DJ	anon	Pfam-B128 (Release 14.0)	Family	Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.54	0.72	-4.12	141	1899	2009-01-15 18:05:59	2004-07-01 17:02:22	12	25	5	0	1889	1923	0	70.40	21	21.44	CHANGED	tpt.phppll...spNh....pplph.........t.phsLs-LL..hhNssplpl..tp.s.....lo.sc-lNlFLKH..WlpG.usscLchhplp	.....................................................ph.........pplplt.............psphlsl.-.cL.L...th..s.sp.p.l.p.l.....pp..sp......lo..sc-l.NpFlKp..W.h..p...G...sp.s.pLchlpl.t...................	0	176	183	1889
+7566	PF07736	CM_1		Chorismate mutase type I	Bateman A, Griffiths-Jones SR	anon	Bateman A	Domain	Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].	21.20	21.20	21.20	35.40	21.10	17.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.31	0.71	-10.46	0.71	-4.01	57	434	2012-10-01 19:40:00	2004-07-07 16:22:31	6	2	424	49	151	378	287	116.20	43	92.42	CHANGED	lRulRGATTlspNosctIhpAspELlppllpcNslps.--llSlhFosTpDLsAsFPAtsARph..GW.psVPLlsspEhsV.GuLs+CIRVLlahpospsp..tclpHVYL+sAtsLRPDls	....hRuIRGATTl-pNst-pIhpATpELlpcllppN.plps.-DllSlhFTsTpDLsAsFPAtAsRph.......G.a.ptVPLhsspEhsVsGuLs+CIRlhlpssocp.sp..pcIpHVYL+sAtsLRPDL.s.....	0	67	120	140
+7567	PF07737	ATLF		Anthrax toxin lethal factor, N- and C-terminal domain	Andreeva A, Bateman A	anon	Pfam-B_23800 (release 14.0)	Domain	The C-terminal domain is the catalytically active domain whereas the N-terminal domain is likely to be inactive.	21.40	21.40	23.10	22.90	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.60	0.70	-4.96	4	70	2009-09-11 08:46:23	2004-07-07 16:59:27	6	7	32	77	5	78	0	187.20	36	41.50	CHANGED	hK.-hhpplV+l-lps-phsKtptspcLlcKlPp-VLEhY.pslGGcIYlsDt-lspHhpLpslScccphlhsupGcph.htp+FVFsKtshpPhLlIps.cDYs.sp.pShpVYYElGKuI.hDhhS.pthcLtsP..cFlshlsplsst..........DpDupDLL.....FspphKE....cspslslsalcpN.sEFQcsFAcAFuhYapPcH+-sLclY..APchFpYMschpchthp	.........................................K.-.h.p.sphph.spphsKh.th.chhchls.sVhphY.ptlstphYhh..-hhpphp.p.lpc.pp..hs..G.......+aVatc.t..shh.....pD.h.pp.puhtlYh..u+.l.hch.S....pl.ps..tFlp.htph.s...........DpsupDLl.....FpphhKE....cspsl..s.l.s....alcpN.sEF.chFAcAFuYY.a.sP..D........H+shLcla..APcsFpYhschpK..hp......	1	1	4	4
+7568	PF07738	Sad1_UNC		Sad1 / UNC-like C-terminal 	Wood V, Finn RD	anon	Pfam-B_5052 (release 14.0)	Family	The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development.  The S. pombe Sad1 protein localises at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain [1-2]. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2 [1].  The SUN domain of Sun2 has been demonstrated to be in the periplasm [2].	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.70	0.71	-4.37	25	1140	2012-10-03 19:46:52	2004-07-08 10:09:58	8	33	300	4	758	1131	30	126.30	24	15.87	CHANGED	hshtupsspsllpps...hhsusCauhpuspsalslcLuctIhlpslsltHhpp.......h.SSAPK-FpVhuppphsptp.......hhhLGpFph.stsspshQoFplpss..t.......hhchV+lclhSpa....GsstasslhtlRVaGps	..............................................................................................h....ttsspsll.p.s...hh.ssC.h.s.....h...p.......s......p......p.....s...a.l......s.lcLsp.I.hssslslpH.hth...........h.sSuP+cF.plh.....u..................p.p..sspp.........................hh.hL..G.p.....aph...s....p..s..s....p......s...l.....Q..s.F.t.l...p...pt..........................hhphlclc.lhSpa.....Gp..ta..ssl...t.hRVaGp...............................................	0	233	353	597
+7569	PF07725	LRR_3		Leucine Rich Repeat	Studholme DJ	anon	PfamB-184 (release 14.0)	Repeat	This Pfam entry includes some LRRs that fail to be detected by the Pfam:PF00560 model.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.38	0.73	-6.54	0.73	-3.89	74	609	2012-10-02 21:32:02	2004-07-26 15:33:50	7	122	16	0	284	634	0	19.90	51	2.28	CHANGED	pLVcLphttS.pL.c+LW-Gsp	....LVELshppS.pL.EKLWcGsp...	0	96	177	191
+7570	PF07739	TipAS		TipAS antibiotic-recognition domain	Bateman A, Finn RD	anon	Pfam-B_8785 (release 14.0)	Domain	This domain is found at the C-terminus of some MerR family transcription factors. The domain has an alpha-helical  globin-like fold [1]. The family includes Mta a central regulator of multidrug resistance in Bacillus subtilis.	23.70	23.70	23.70	24.00	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.49	0.71	-3.78	164	1938	2009-10-27 17:45:06	2004-07-27 13:56:40	8	15	1353	3	329	1455	73	113.30	19	48.65	CHANGED	paspEspp+aGp...pthpt.ttp............thsc.pchpphppp....hpplhppltphhpps..sssupcspplscpapphl.s....pahs.....hstp........hhtsL...uphY...hsD.t+Fpphhc.ph.....st.Ghu.palpcAlptas	........................................................atpEh.pcaGp...p.htp..pc...................sp..pc.pphppp........hsplhpplsphhppt...sssupcsQphspcahphlp....phhs.........hs.c.........hhst..l...uphY..............hs-...sc.Fpp.....h..s..ph.............ss..uhu..pals-Altha..........................................	0	107	213	277
+7571	PF07740	Toxin_12		Ion channel inhibitory toxin	Bateman A, Finn RD	anon	Pfam-B_20319 (release 14.0)	Domain	This is a family of potent toxins that function as ion-channel inhibitors for several different ions. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC responses [1]. Huwentoxin-IV, from the Chinese bird spider, is a highly potent neurotoxin that specifically inhibits the neuronal tetrodotoxin-sensitive voltage-gated sodium channel in rat dorsal root ganglion neurons [2]. Hainantoxin-4, from the venom of spider Selenocosmia hainana, adopts an inhibitor cystine knot structural motif like huwentoin-IV, and is a potent antagonist that acts at site 1 on tetrodotoxin-sensitive (TTX-S) sodium channels [3]. Study of the molecular nature of toxin-receptor interactions has helped elucidate the functioning of many ion-channels [4].	21.00	21.00	21.00	21.40	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.46	0.72	-3.46	31	254	2012-10-01 22:06:18	2004-07-27 13:59:12	7	1	24	18	1	274	0	30.60	39	40.83	CHANGED	-CtthattCssss-.CC..tshsCppc....h..pa..Cta	....-CttahspCs.sps.CC..sthsCpsc....a....+W..Csh.......	0	0	0	1
+7572	PF07741	BRF1		Brf1-like TBP-binding domain	Bateman A, Finn RD	anon	Pfam-B_18050 (release 14.0)	Family	This region covers both the Brf homology II and III regions [1]. This region is involved in binding TATA binding protein [1].	25.00	25.00	27.40	26.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.38	0.72	-3.77	42	348	2009-09-11 07:42:02	2004-07-27 14:01:28	8	11	267	4	234	338	3	99.70	33	16.01	CHANGED	D-.E..lcthl.LsEcEschKpplWhphNc-aLhcpcpKp.........................h+tctcp...........psstpcc+p++tpcpp..................................sssspTAuEuscphLpc+s..hSpKINY-sLcsLa	................................D-.E.lc.phl.Ls-pEs.clKpplWh..p.Nt-YLc...cQppKc..........................h+t.ttcpt.........................tthp.c++....++sp.cpct.......................................ss.usTAuEAhcpML.cc+p....hSpKINYcsLcsL.............................	0	79	129	192
+7573	PF07742	BTG		BTG family	Bateman A	anon	Pfam-B_9208 (release 14.0)	Family	\N	23.00	23.00	24.10	25.70	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.61	0.71	-4.59	31	473	2009-01-15 18:05:59	2004-07-27 14:07:20	7	7	125	8	259	429	1	113.10	44	43.74	CHANGED	MptElssuVsFls+hlpp+th...LsccplphFupcLpphLhc+YpsH.WaP-pPpKGpuaRCI..RIN...cphDslltpA...............spcSGLshpcLh..LPpElTlWlDPhEVshRhGEcu.shsVhhhp	.........................Mp.EItsAlsFlhphLhs+......Lscc...plphFuppLpclL.pc............+Y.c.sH.WaP-+PtKGSua.R.CI.....+Is........cph....DPlltpA................upcuGlshp-lt.t....L.P...........p............E..L........olWlDPhEVSaRlGEcG.shpVhh.p...................	0	61	82	156
+7574	PF07743	HSCB_C		HSCB C-terminal oligomerisation domain	Bateman A, Finn RD	anon	Pfam-B_6234 (release 14.0)	Domain	This domain is the HSCB C-terminal oligomerisation domain and is found on co-chaperone proteins.	21.60	21.60	21.60	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.46	0.72	-3.52	143	1500	2009-01-15 18:05:59	2004-07-27 14:15:24	8	10	1465	13	424	955	122	77.40	34	40.93	CHANGED	htDs..tFLMppMEhREpL--httt....pst.spLpplppclppphcphhpplspth...s........ppshppAsctlp+L.......+Fhp+.lppclcp	.....................s.pDssFLMcQhElREcL--lptt...........cs-.spLcshhpclcphhcsthpphsppL........-...............spsassAA-pVRKL..........+FlcK.Lpsplcp.........................	0	114	216	329
+7575	PF07744	SPOC		SPOC domain	Bateman A	anon	Bateman A	Domain	The SPOC (Spen paralogue and orthologue C-terminal) domain is involved in developmental signalling [1].	21.30	21.30	21.40	21.40	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.72	0.71	-3.63	58	707	2009-01-15 18:05:59	2004-07-27 14:20:39	8	40	232	1	436	686	1	115.20	24	8.36	CHANGED	WpGh.lshpshsphsspuphlsGp...ppls.ptl.........................................................PtplshpuRlchppltchhpplptst......plhllsl................ssppspts.........hpp.hhsYhps+pR.h......GVhplss.................stshYlh.P	..............................................................................WpGh..lshp....s.....s....p....hssphahlsGs.....tplh.pp.tL.........................................................s.pIs..phRls..splpchhpclpsus.st.......thhllsl................t.s..ss.tpppps...............hps.lhsYLpp+pt..s.GVh.sl.ss...tt..............stslalhP................................	0	106	174	299
+7576	PF07745	Glyco_hydro_53		Glycosyl hydrolase family 53	Bateman A, Finn RD	anon	Pfam-B_5764 (release 14.0)	Domain	This domain belongs to family 53 of the glycosyl hydrolase classification [1].  These enzymes are enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known [2] and has a TIM barrel fold.	20.70	20.70	20.80	21.10	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.22	0.70	-5.65	16	584	2012-10-03 05:44:19	2004-07-27 14:21:50	8	37	453	23	213	550	107	322.00	33	69.58	CHANGED	h+GsDlS.lhp.........................................hEpsGss..apssNGpppDhhplL+s.sGlNhlRlRVWssPhD..............G.sDlccslphAKRAcstGM+lh.lDFHYSDpWADPu+QphPpAWssh.sh-pLpps..lYsaThssLssh.pcsGlpsshVQVGNEhssGhLWs.Gp........sssasphupLlpuGhpAV+-..........lssssKlhlHLssGts.sp.phaacpltpp..G....sDaDlhGlSYYP...aWpu..........oL.....ssLpssLpshtspYsKsVhVsETuaPao........s..sp.t....h.shPhospGQsshlpslhplVpsl........scGlGlFYWEPAWlsss.....................................h.tGsshssp.shFD..hsupsLsSlssF	..............................................................................................h+GuDlShl.p.........................................hEp.p.Gsp..ahs..t..s...G.........t...p...p.D...hhplL+s.pGlNhlRlRl.WssPts............................................G....ss..hs.pslthA+..RA+stGh+lh.lDFH.YSD..hWADPu+QhhP.....pAWtsh........shspLp.ps............lasaTtsslsth..cptGl.......P-hVQlGNEhssGh..L......WstGp...............................................sssa.sp..hAtLlpuGhpAV+c..................sssp.s+l..hlHls.s........Gt.....s.s..s.......t.......h........p...a...aacpl.ppp.....s..........scaDlIGh.SaYP...........aWpu.................sh.......ssL..p..sshs...sls.p+.Y.s..K.c.lhVsEsuasas.t..s.t....s.hst.t.............sh.shospGQtphlpc...lhpt..ltsl.t......spGhGlFYWEPsWhs.s...................................................h...Gssh..tst...shFD...pGp.s.h..uht...............................................................................................................	1	77	147	182
+7577	PF07746	LigA		Aromatic-ring-opening dioxygenase LigAB, LigA subunit	Bateman A, Finn RD	anon	Pfam-B_18522 (release 14.0)	Family	This is a family of aromatic ring opening dioxygenases which catalyse the ring-opening reaction of protocatechuate and related compounds [1].	23.40	23.40	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.48	0.72	-3.98	40	275	2009-01-15 18:05:59	2004-07-27 14:23:53	6	3	207	4	91	247	101	83.40	30	44.05	CHANGED	LNpashoL.hcspsRccFhuDccAhh-casLocpp+pAlhsRDhtthlphGuNhahLtKluulhGlsh.phsusMsG..hoh--apphhhs	........lNcahhpL.hcst.RpcFhs...D.cAhhccauLoc-p+pAlhsRDhtsLlphGsshahLtKh..uus.Ghs..phhu..shpG...oh-patthh..s............................	0	18	46	75
+7578	PF07747	MTH865		MTH865-like family	Bateman A, Finn RD	anon	Pfam-B_25445 (release 14.0)	Family	This domain has an EF-hand like fold.	25.00	25.00	35.20	34.90	21.90	20.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.53	0.72	-4.35	6	69	2009-01-15 18:05:59	2004-07-27 14:27:15	6	1	56	1	52	72	0	75.50	37	86.51	CHANGED	--l+tpll-hhKsA-.FPIps..ELhuALPsGhsToCp.Gs.ElpAuEhs.KLlTcsDFPaKsu-plADpll....c+suL	..p-l+tQlh-uhc..sAc..FPIpo.h-LlsALPsGssTsCpsGs..hpl.TAtEhs.KllsssDFPacsA-slA-sll....pcs...........	0	12	35	46
+7579	PF07748	Glyco_hydro_38C		Glycosyl hydrolases family 38 C-terminal domain	Finn RD, Bateman A	anon	Pfam-B_731 (release 3.0)	Domain	Glycosyl hydrolases are key enzymes of carbohydrate metabolism.	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.64	0.70	-5.68	45	2571	2012-10-02 23:57:29	2004-07-27 14:36:28	8	30	1251	65	913	2233	104	416.20	15	45.85	CHANGED	tslhlaNshsappsphVplssstsshthtstp..........................................................hhh.hsplPsluhtsh.ht.spt.p.tt...........................................h.l.....cNshl+lphsss.GtlpolhDcpss+chh.........hspphthacs...................hptt.p.t...h...usuh.hh.....ppsshpstl.h.ht................................tsshlsphlplhsss................ppl-hcspVc.hpppcp......lpspFssslpu......................spshY-sphGhhhc........shphs...s.h-tsha...........plssptalp.uc...........slulLs-staGsss............tssplcLoLhRs.........................................................cstsD...pupthh............saslhscssshhtht...................ssptuh.............plptPhhh....................hptht..s..h.hsls..sl.................hh.thK.scst..................pshlL+hh-htsspsctplth.shs.ttsph..pslh-t............................................................................................................t.pspphplplpPhEItThp	......................................................................................................................................hhlaNs.s..h..p..t..h......l.....p....h.........h.......................t..............h...t.................................t..........................................................................................................................................h.h...........p....lPsh.u.h...p.sh......ht............t.t......................................................................................................................................................................hhl..........pNt..h...hpl.ph..s..t.p....G..h....l.p..pl...h....c...p..p..s...s.pp..h...................................hssph.hhaps...........................................hptt...................st..s....h..hh...................p..ss.hpst.h..hphph..................................................................t....p...........t........l....p..p..h..l.p.l..htss........................ppl-hc..s....p.lc...htppcp.......................L.+l.th.ss..s..l.p.s......................pps.h.h.p.t.t.h.GhhtR..........................................shp.p...........pshpt..sh.h......................h...s.....t.....t.t.....a...h..p...h..sc......p.............................slul.hspshh.uhs.s...........................ss.p..l.pl..o..L..hRs.........................................................pshs.D..........ps.pthh........................................................paul.h.sps...t...h......ht..............................................shppuh............................................th.p.t.Ph.hh.............................................................hp..h.............................s.h...p..h........s..l................................................................hpshK.up....st............................................................................tthllR.hhp.....t.t..t.s.p.s.t.h............s...........sp......h......slhpt..........................................................................................................................h...h...t...shplhoh.................................................................................................................................................................................................................	0	333	530	740
+7580	PF07749	ERp29		Endoplasmic reticulum protein ERp29, C-terminal domain	Finn RD	anon	Pfam-B_5062 (release 14.0)	Domain	ERp29 is a ubiquitously expressed endoplasmic reticulum protein found in mammals.  ERp29 is comprised of two domains. This domain, the C-terminal domain, has an all helical fold [1]. ERp29 is thought to form part of the thyroglobulin folding complex [2].	21.70	21.70	22.40	23.30	20.10	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.07	0.72	-3.36	36	300	2009-09-11 09:36:09	2004-07-27 17:35:15	7	10	234	12	194	303	6	91.90	30	27.52	CHANGED	GsltsLDplltcassus...tptppllscscctsppLp.....st...+aupaYl+lhcKlhpps.......p-YspcEhpRLc+lLp......GulussKtDElhh+tNILppFt	..................................................GpltslDslstcahsus.t..pppp.....pllpcscctspplp...............tttt..chAchYlKlhcKlhcpu.......p-asppE.hpRLp+lLp.......sslus.sKtD-lpt+.hNILpsF..........	1	70	115	159
+7581	PF07750	GcrA		GcrA cell cycle regulator	Thanbichler M, Finn RD	anon	Pfam-B_23428 (release 14.0)	Family	GcrA is a master cell cycle regulator that, together with CtrA (see Pfam:PF00072 and Pfam:PF00486), is involved in controlling cell cycle progression and asymmetric polar morphogenesis [1]. During this process, there are temporal and spatial variations in the concentrations of GcrA and CtrA.  The variation in concentration produces time and space dependent transcriptional regulation of modular functions that implement cell-cycle processes [1].  More specifically, GcrA acts as an activator of components of the replisome and the segregation machinery [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.14	0.71	-4.04	8	480	2012-10-04 14:01:12	2004-07-27 17:35:51	6	7	310	0	157	401	1392	140.20	30	85.47	CHANGED	MsWTDERVEtLKKLWp-GLSASQIAAQLG.....GVSRNAVIGKVHRLuLoG....Ru+s.t.osAssRs++ss.s.t.........................ssutpuLphchss-lsscsshtsstssVsshsRplpLLELuE+oC+WPIG.DPtsE-FsFCGs.cus-uuPYCshHuRlAaQPsuc+RRsc	...........................................................................pWT-E+lp..hL+clW.tcGhSuupIAtpL.G......loRNAVl...GKsH.R..L.t..Lss..........+sp..s................t.....t.s.s.....p...t..tst...................................................................................................tt.h......t............t..................................t.............tt.h..tl.h...pL.....sc..p.....pC+WPl.......G...-P....s.....cFh.FCGt.....ts...tu....PYCt.H.s.tlAapshttp....t...............................................................................	0	40	96	114
+7582	PF07751	Abi_2		Abi-like protein	Fenech M	anon	Pfam-B_8740 (release 14.0)	Family	This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins,  which are involved in bacteriophage resistance mediated by  abortive infection in Lactococcus species [1,2]. The  proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function [3].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.43	0.71	-4.12	111	1544	2009-01-15 18:05:59	2004-07-28 09:55:11	6	5	1091	0	266	1249	75	178.60	18	63.71	CHANGED	pphLpp.luYaRl.ssYhhsh.t.t.....................htts.spFpplhpLYhaDpcLRthlhcslpclElslRstlstt..lup.............t..ha.p.tphhptt.............................................hhpphp......pplpcspt....p....hpaatpph...........tthPhWhhh.....ElhshG....................phsphap.h.tp.............ttplspp...............hs...............hp.........tphlpshlcslphlRNhsAHasplasp	...................................................................Lpp.hs.Y.a.ph.psYhh.h...............................hh.s.hphpplhsL..YhhDpcL+thhhphlttlEhsl+stlsth..lsp...........................t....h..ahp......phhpt.t.........................................................................hhpphp.......ptlpcsp..............t...........hpphh.pph.........................................tphPhWhhh........chhshG......................phs.phap.h...t.................t.thh.pp................................................ht.......................................hp........hp.ht.s..h....lptlp..lRNhsAHpp.lht........................................................................................................	0	72	163	220
+7583	PF07752	S-layer	DUF1608;	S-layer protein	Fenech M, Eberhardt RY	anon	Pfam-B_2293 (release 14.0)	Family	Archaeal S-layer proteins consist of two copies of this domain [1-2].	30.00	30.00	30.70	30.30	29.60	29.70	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.46	0.70	-5.18	14	125	2009-01-15 18:05:59	2004-07-28 10:41:59	6	15	13	0	123	125	2	236.20	27	60.47	CHANGED	lRGslaD.........s.stssshsWsspsFuGFYYslccs..................lsoEshslhthss..scsIs-GsLVYsTpsh.spaEht..............sW..ssYpllGFhuccYhAs.sDss.............stLuplllD..u-DKcsl.hoG-sh-Lt..............cGYSLplspVDVsGs+VWlpLpK-G-hlDsshlsssss.......alacs-lu-s...-DlshhhlalspVFtGspsohlhlcula.Is.DshlcIpsGDpFGchElsphSpssIphcN-DohoLspsss..hplhsshhFpsuD	..............................................h..........................h.Wss......satuFaYslsps................htsEphth.........sp.ltc.....s..s...l.Ypo..p......s...p...acht..............sh..tpY.h..luahu-cYhshhssss........................spLu+lLlD.........s-cctol.psGpsLs.Lt..............-GYsLplppl...Dl-Gs+ValpLpKDGphVDspllssus..s.............asYcp.-lsst...pDlslltl+lc.plFpGsp...sshshl-GlaQIu.-shhplppGDpaGphclppls.....t...s..t..I.hpNp.s.s.hsLppsps...tlhtth..htsus..................................	0	26	83	92
+7584	PF07753	DUF1609		Protein of unknown function (DUF1609)	Fenech M	anon	Pfam-B_2149 (release 14.0)	Family	This region is found in a number of hypothetical proteins thought to be expressed by the eukaryote Encephalitozoon cuniculi, an obligate intracellular  microsporidial parasite. It is approximately 200  residues long.	25.00	25.00	56.80	56.70	16.70	15.80	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.52	0.70	-5.03	9	42	2009-01-15 18:05:59	2004-07-28 10:43:16	6	2	6	0	26	42	0	199.40	58	45.79	CHANGED	EsEputEAEssh.Eh....AtsK+KsutcKScGtc+pYKlH+RVLRWpKSsE+IKcELDcGpEE+W+G+SlEEI+EQKhlHDIsEVhcLLRSc-.sD+FFhcTG+YMKGGSERW+MVAlGlLEpGGcK+lGsVEVGLFKsc.sGpsVlYHLMF+PTshEctGcVsssuFu+uDDV-cI--s..-spDhuGFpYPpGVRsEhV+ssspF+IVWRNP+sTSEVLRoLTlhphPpl	............EsEtutEsEhs..Eh....uss+cK....su.K.....KScGsc+pYKIH+RVLRWpKSPEKIKcEhD+GSEE+W+GRSlEEIKEQKhlHDIstVlcLLRScD.AD+FFhcTGcYhKGGSERtRMVAIGlLEsGGc.+hsGVVEVGhFKDs.sGssVVYHLMF+sTthtphGtsht...sthschss.lttlcct..c.pD.ttF.YP.slp.EhspttstFpI.ats.psTu.llppLhl.phs..................	0	26	26	26
+7585	PF07754	DUF1610		Domain of unknown function (DUF1610)	Fenech M	anon	Pfam-B_8731 (release 14.0)	Domain	This zinc ribbon domain is found in archaeal species. It is likely to bind zinc via its four well-conserved cysteine residues.	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.78	0.72	-7.06	0.72	-3.81	21	205	2012-10-03 10:42:43	2004-07-28 10:44:10	6	2	117	0	143	189	34	20.80	46	59.03	CHANGED	CpsC......RchussasCPpCGh	...CppC.......Rcp..ustahCPsCGh.	0	38	81	115
+7586	PF07755	DUF1611		Protein of unknown function (DUF1611)	Fenech M	anon	Pfam-B_8752 (release 14.0)	Family	This region is found in a number of hypothetical bacterial and archaeal proteins. The region is  approximately 350 residues long. A member of this family (Swiss:Q6M063) is thought to associate with another subunit to form an H+-transporting ATPase, but no evidence has been found to support this.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.71	0.70	-5.77	79	333	2012-10-05 12:31:09	2004-07-28 10:48:20	6	4	302	6	140	392	459	289.80	34	83.25	CHANGED	h-..hchsGpsss........tslPlhsshpts.....ttsscslllGlAstGGhls.tsWppslhpAlctGhslsSGLHs.hL......s-cPclsthApp..tGtplhDlRpP.stsh.tlusGpt+...........t.sspRlLsVGTDCulGKhsTuLtlpcuhppcGlcusFhATGQTGIhI.uGpGlslDAVsuDFsuGAlEtll.csst.....pp.chhllEGQGSLh...HPuauu.....lohuLL+GupPDullLsHcssRpphcshsp...hsl.Pslpphlplhptlushs........spVlGlu.lNTpsls..-pp.utphltchppch......uLPssDPlRp..G.ss..pll	.................................phsGppss.........hslP.hs.hpss........stsscsLllGlAstGGhls..ptWhpslhpAl.ctGhslsoGLHp.hL......s-.sclst.hApp..pGt..plaDVRps.s.sh...slusGpt+.............sucRlLsVGTDCulGKhhTuLtLccshcc+Ghc...u...sFhATGQTGI....hI..sGpG.lslD.....A...VluDFhuG...AlEtls.css......cc.ch.llEGQGSLh......HPuauG.......VohuLl+GuQPDullLsHcssRpphcshsp...hsl..Pslpphlchh.thuphs.......stspllGlu..lNTptl....s..-p.c.Atthhtchppch......ulPssDPlRh.Gsstl...................................................................................	0	35	86	119
+7587	PF07756	DUF1612		Protein of unknown function (DUF1612)	Fenech M	anon	Pfam-B_8688 (release 14.0)	Family	This family includes sequences of largely unknown function but which share a number of features in common. They are expressed by bacterial species,  and in many cases these bacteria are known to  associate symbiotically with plants. Moreover, the majority are coded for by plasmids, which in many cases are known to confer on the organism the ability to interact symbiotically with  leguminous plants. An example of such a plasmid is NGR234, which encodes Y4CF, a protein of unknown function that is a member of this family [1]. Other  members of this family are expressed by organisms with a documented genomic similarity to plant symbionts [2].	30.10	30.10	30.60	49.50	27.90	30.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.72	0.71	-4.05	18	141	2009-01-15 18:05:59	2004-07-28 10:54:13	7	2	98	0	42	113	1	126.70	55	35.37	CHANGED	sLlaDsDWDE-sRLsEWRuVlspscsL..PPlLpAAlhhDAWppLEsLQ+usWLGRLLsAuhLRpcGhss.uHLsulshGLKslPh-RRRpRsRtoRLhuhLcultsAAptGhKEHDRLslARp.MpR+LcG	..............tLlYDsDWDEDuRLpEWRss.hststsL..PPlLpAAlhaDAW.pLEVlQRusWlGRLLsAuaLRpuGlsu.sHLsAlsLGL+shts-cRRupsRssRLtsFLtAlptAAEssMKEHDRLhLARcQMpRKL+G.......	0	4	19	29
+7588	PF07757	AdoMet_MTase	DUF1613; 	Predicted AdoMet-dependent methyltransferase	Fenech M	anon	Pfam-B_8934 (release 14.0)	Family	Proteins in this family have been predicted to function as AdoMet-dependent methyltransferases [1].	20.20	20.20	20.20	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.45	0.71	-3.95	3	246	2012-10-10 17:06:42	2004-07-28 10:55:27	8	4	214	0	186	308	53	106.20	44	20.68	CHANGED	LV.NlEKYNDLYsELKQKYuQpLV-pW...sEsTDPtKFVFEDLAIAAYLIhLW+QTpSu...pp.pSFVDlGCGNGLLVYlLsuEGY+GYGaDlRKRKLW-hYPs-sQVcLhEKslVP	.......................................................l.s..papshYtpLKpKYuppllcsW.......sE..sTDPpKaVaEDlA..IAAaLl.LW..p.p....h.sp........................pth.....u.........FVDlGCGNGLLVaIL.pEGa.pG.h.GhDsRcRK.Wsha.s...spsp..L...................................	0	54	91	149
+7589	PF07758	DUF1614		Protein of unknown function (DUF1614)	Fenech M	anon	Pfam-B_8844 (release 14.0)	Family	This is a family of sequences coming from hypothetical proteins found in both bacterial and archaeal species.	22.40	22.40	22.60	22.50	21.10	21.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.20	0.71	-4.54	48	186	2009-01-15 18:05:59	2004-07-28 10:56:30	6	2	156	0	112	170	2	169.60	31	72.00	CHANGED	llGShI.....NIPltp..tt............................hhGh.h....Ph..h..tpshlAlNVGGAlIPlhlulY..Llhp....h.......tsllusllsullsahhu+sl..........sGlGIssPshlsPlsAulsAh....lhuttht..............sAYluGslGoLlGADllpL...t...clhphs.ssh..l.......SIGGAGsFDGIFloGllAlLL	..............................................lhsS.hNlslhp...t..............................hhsh.h.h...s.........pphlAlNlGGAlIPlhlulY...Llhc..........t.hltsllusllsullsahhu+sl.........sGlGI.hhP...salsPllAu.l.hAh...........lhuht.hc.................sAYluGslGsLlGADllpl.........t....plhphu...ssh...l..............SIGGAGsFDGIalo...GllAlLL...........	0	46	80	98
+7590	PF07759	DUF1615		Protein of unknown function (DUF1615)	Fenech M	anon	Pfam-B_8943 (release 14.0)	Family	This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. Swiss:Q8Z8Z7, Swiss:Q8ZRF4) are thought to be lipoproteins. Another member of this family (Swiss:Q93SV8) is thought to be involved in photosynthesis [1].	25.00	25.00	26.30	26.20	20.90	18.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.94	0.70	-5.67	22	632	2009-01-15 18:05:59	2004-07-28 10:58:44	7	1	622	0	68	326	17	315.30	72	86.98	CHANGED	uslpDRpGWApDItsAhps.tlssoscNlCuVLAVsEQESsFpsDPsVPGLu+IuhpEI-pRAs+h...........tlPthllcsALphpSP.sG+oYpcRlculRTE+-Lstla-Dhl...........stlPhGppLFus.....hNPV+TGGPMQVSItFAEp+u+...tYPasss.uolRcEVFoRRGGlaFGhA+LLsYPssYspslYRFADFNAGaYASRNAAFQsAlSRloGhtLALDGDLlpYss.......stsusTEhAlhsL..upcL...shscspIRcsLcptcs.sFpcTtLYcpVasLA-+psG+shPRAhLPtIpLcSPKI.oRpLTTAWFAcRVDpRap+CMpR	....A.SVKDR-AWAKDlATTFcSQGLAPTlENlCSVLAVAQQESsYQADPsVPGLSKIAWQEIDRRAERh...........HIPuFLVHTALKI+SP.NGKSYSERLDoVRTEKQLSAIFDDhI.............uMV.PMGQTLFGS.....LNPV+TGGPMQVSIAFAEQHsK...GYPWKMD.GTVRQEVFSRRGGLWFGTYHLLNYPAsYSAPlYRFADFNAGWYASRNAAFQNAVSKASGVKLALDGDLIRYsS.......KE.PGKTELAsRKL..Au+L...GMS-uEIRRQLEKGDShuFE-TALYKKVYpLAEAK.TGKoLPREMLPGIQLESPKI.TRsLTTAWFAKRVDERRARCMp.......	0	11	22	43
+7591	PF07760	DUF1616		Protein of unknown function (DUF1616)	Fenech M	anon	Pfam-B_8886 (release 14.0)	Family	This is a family of sequences from hypothetical archaeal proteins.  The region in question is approximately 330 amino acid residues long.	31.60	31.60	33.10	32.70	31.40	31.20	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.80	0.70	-5.27	38	205	2009-09-11 00:12:54	2004-07-28 11:00:14	6	5	101	0	137	214	7	244.00	22	72.95	CHANGED	Lhlllhhsllshlhlh.hssht...pohlRslLGlsh..lLFlPGYsLlusLaP................p+psLss.....lERh.sLShGLSIullsLlGLsLNaos.......huIchhPlll.oLshhollhshlAhhRRtphPssctath.hpthh.t................hhhtsssph-phLsllLllullssls.slsaslhhPcpsEpFTEFYlLG.pt....hAtsYPsphhhGpptslhlG.................lsN+EhpshsYslclhLpspphs.......p.ph............slss...p......pohppshphps..hhups.clpaLLapcs...................ppshsY+sl+LalsV	..................................................................................................hhhh.hhhhhhhh..h...........lR...hhhuh.h....lhF.hPGYshlthLaP....................................tttpl.s........l-Rh.slShGl...SlulsshlGlhlshs........hslphhslhh.slshhslhhshluhhR+hph.............h.................................................................h..p.phls.hllhl.llhshh..hhshhhh.s.....tt..s.....ctaothhlls.tt.....hutsYssphh.up...lhlt.................lhNpEhpshtYhh.hhltp..ht.........................th......h......tlst.........s........................tshp..hph..t.........stp...pl.h..hLaptt.........................t.t.shhthhlhlp...................................................................................................	0	19	77	107
+7592	PF07761	DUF1617		Protein of unknown function (DUF1617)	Fenech M	anon	Pfam-B_8981 (release 14.0)	Family	This is a family of sequences from hypothetical bacterial and bacteriophage proteins. The region in question is approximately 150 residues long and is highly conserved throughout the family.	21.10	21.10	21.40	22.40	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.92	0.71	-4.14	2	86	2009-01-15 18:05:59	2004-07-28 11:01:05	7	1	53	0	8	64	1	137.70	43	98.75	CHANGED	MDLTLKNK-LNTLYpVLDKIKlTNMRANRGRAKLLAKV.sKlsEYAKDEhDlID.YsAKscDDKalhD-+tN.KltDsuKLsELNDhLsELAsE.IVIKGGEYSKRFIDFLpaL.EsEDEFTSpEIlLIDNILEQFEES.KGE	......................MplTl+N+-LsslasVL-cIKlpsh..RAsRGRAKLLuKVhcKlcEYAKDEsDLIchYAtKDcDGK.all.D-+.tNh....KL.........s.D.PsKl.....c.....EhNchLsELusEcIsIcGsEYS+RFhDhlpaLt-sEDEhoup-hll...hDplLEpaEtu................................	0	2	5	7
+7593	PF07762	DUF1618		Protein of unknown function (DUF1618)	Fenech M	anon	Pfam-B_8857 (release 14.0)	Family	The members of this family are mainly hypothetical proteins expressed by Oryza sativa.	21.00	21.00	22.00	21.40	19.30	20.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-11.16	0.71	-3.95	61	623	2009-01-15 18:05:59	2004-07-28 11:02:59	9	14	11	0	353	498	0	130.80	21	29.62	CHANGED	W.V..DLs.tGlLhCDsh...s..............t......s....clcalsLP.ss.hssttt....................pt.......hptaRs.lul.....ssG....pl+aVplstt.t...............................................ssshhlssWoL..............ssht..Wph-s.plshsclWstcs............apt.t........l.Pp.......h..h..Phl..uh.cs....slla	......................................W.V.D....Lh...t.G.l.l.h.C..D.sh.....s.....................cp.........splcalsLP..sshh.sttp.....................pts.phhR.s..lss.......spG.....pl+aVp.lptt......................................................tshhlssWsL.................sttpWph..-t..pl.s...hsclhttts..................................h.t.t......l..sp...............hh..h..Phls..ps....thh........................................................	1	0	66	213
+7594	PF07763	FEZ		FEZ-like protein	Fenech M	anon	Pfam-B_8854 (release 14.0)	Family	This is a family of eukaryotic proteins thought to be involved in axonal outgrowth and fasciculation [1]. The N-terminal regions of these sequences are less conserved than the C-terminal regions, and are highly acidic [1].  The C. elegans homolog, UNC-76 (Swiss:Q7JNU9), may play structural and signalling roles in the control of axonal extension and adhesion (particularly in the presence of adjacent neuronal cells [2]) and these roles have also been postulated for other FEZ family proteins [1]. Certain homologs have been definitively found to interact with the N-terminal variable region (V1) of PKC-zeta, and this interaction causes cytoplasmic translocation of the FEZ family protein in mammalian neuronal cells [2]. The C-terminal region probably participates in the association with the regulatory domain of PKC-zeta [2]. The members of this family are predicted to form coiled-coil structures [2,3], which may interact with members of the RhoA family of signalling proteins [2], but are not thought to contain other characteristic protein motifs [3]. Certain members of this family are expressed almost exclusively in the brain, whereas others (such as FEZ2, Swiss:Q76LN0) are expressed in other tissues, and are thought to perform similar but unknown functions in these tissues [3].	28.10	28.10	28.40	29.50	26.30	28.00	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.55	0.70	-4.66	10	222	2009-01-15 18:05:59	2004-07-28 11:03:54	8	5	82	0	108	181	0	207.80	46	62.63	CHANGED	ShEDLVNpFDEKLolCF+NYsssTEslAP...V+....spoEEEhLpD--lWsALTDNYGNlhPlDW+sSasRsLHhssLN...Lt.......................................pussssspl...cpSDDEELpEphDMHolIluslp.......EEPLhTADQVIEEIEEMMQESPDPE---.........ssspS-slShLppElpuLppussss..............sapEcL+pLSsScLsElL-ElEsAIR-YSEELlpQLAlRDELEFEKEVKNSFISlLI-VQNKQKEa+ElhKKK+KhKususp	..................................................h.sLspph-EKlshCFp..s.t.tst...h.As...Vp......ppcphhptpplW.s.LTsNass.h.hshDWcsopscsL.h.hl....h.........................................p..u...s...s.s...h...cts.--EElpEphDhHShI.st..hs.......-EPLhTA-QVIEE.I-EMMQpSPD.PE--.c........................sss.pSc.thohl....p-hp..sh.ps....s.s...............................tE......pl+pLSsocLsElLcElEssI+-aSEELVpQLAhRDELEFEKEVKNSFISlLl-VQNKQKEp+Eh...hKK++K.+shs..............................................................	0	31	41	69
+7595	PF07764	Omega_Repress		Omega Transcriptional Repressor	Finn RD	anon	Pfam-B_63922 (release 14.0)	Family	The omega transcriptional repressor regulates expression of involved in copy number control and stable maintenance of plasmids. The omega protein belongs to the structural superfamily of MetJ/Arc repressors featuring a ribbon-helix-helix DNA-binding motif with the beta-ribbon located in and recognising the major groove of operator DNA [1].	25.00	25.00	25.90	29.30	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.31	0.72	-3.61	2	125	2012-10-02 18:44:02	2004-07-28 11:04:54	6	3	97	14	2	49	0	63.30	79	46.87	CHANGED	MIVGNLGAQKtKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKNGGNVKEVM-.tLcphl+phL.s+h	................hGNLGAQKtKRNDTPISAKKDIMG.DKTVRVRADLHHIIKIETAKNGGNVKEVM-htLcphl+phL.s+h.............	0	1	1	2
+7596	PF07765	KIP1		KIP1-like protein	Fenech M	anon	Pfam-B_2332 (release 14.0)	Family	This is a family of sequences found exclusively  in plants. They are similar to kinase interacting protein 1 (KIP1), which has been found to interact with the kinase domain of PRK1, a receptor-like  kinase [1]. This particular region contains two  coiled-coils, which are described as motifs involved in protein-protein interactions [1]. It has also been suggested that the protein's coiled- coils allow it to dimerise in vivo [1].	20.50	20.50	21.50	21.90	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.44	0.72	-4.14	13	269	2009-01-15 18:05:59	2004-07-28 11:06:16	7	8	37	0	153	254	0	66.70	53	8.18	CHANGED	SWWWs..SHhssKsSKWLppNLpEMDp+VKpMLKLl-E...-ADSFA+RAEMYY++RPELIshVEEhYRuYRALAERYD	..........................................ppspWLtps..Lp-M-ppVKtM.lKLI..--.........-.....u......DSFA++AEMY..Yc+RPpLlshVE-hYRsYRALAERYD...............	0	16	88	125
+7597	PF07766	LETM1		LETM1-like protein	Fenech M, Wood V, Mistry J	anon	Pfam-B_2202 (release 14.0)	Family	Members of this family are inner mitochondrial membrane proteins which play a role in potassium and hydrogen  ion exchange [3]. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.64	0.70	-5.36	13	760	2009-01-15 18:05:59	2004-07-28 11:08:40	8	13	347	1	502	777	35	218.00	28	44.32	CHANGED	KcsLhs+lhcElpHYacGh+LLhh-h+..lSsKllh+lhsGtp....LoRREppQLhRTsuDlFRLV.PFusFlIVPFhEhLLPlhlKLFP.sMLPSTFpopsc+p-....Kh+pplpsRh-hu+FLQcTlc-huhpscsphppttp....cFssFhp+lpsssc..sS....s-EIlchuKlFcD-h.sL..DsLoRsQLsuLC+hhpLpshGTsshLRaQL+h+l+pl+pDD+tIstE.GV-uLostELppACtuRGh+uhGlScEpL+-pLppWL-LpLppplPsoLLlLS	.................................................h....h.chhp.hpha..h....pGh.+LLhh...-..h+....hut...+lhh..+.h..h....t..G...t.................LoRR.Eppp..........L...h+................p.............htDlh+ll.Ph...hhlllP.F...h....ph....LLP.lh.l.+.h...FP..shL.PSTFpsppp...cp.c...................thp..p..hhth+h.....p..........h.t.p.h.l....pp.ph....ppht............t...t....t........t..........phtphh.....p.pl....ptstp......s...............pplh.t...htp.h..Fpsp....sL...cp...ls..p.........p.Lhshs+.......hh..........l.p....s.....h............s..s..s...h........L....Raplph+hp.lpt-D....ph.IthE.....G...l..p.s.......L...s......tELp.AChtRG.....h.psh..s.....h.......s..t.p..hcp.Lp.....................Wlplphp.ths...Llh......................................................................	0	164	274	405
+7598	PF07767	Nop53	P60;	Nop53 (60S ribosomal biogenesis)	Fenech M, Wood V, Mistry J	anon	Pfam-B_8778 (release 14.0)	Family	This nucleolar family of proteins are involved in 60S ribosomal biogenesis.  They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation [3]. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60) [1]. This protein has been found to interact with herpes simplex type 1 regulatory proteins [1].	24.90	24.90	25.30	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.38	0.70	-5.47	25	375	2009-01-15 18:05:59	2004-07-28 11:11:04	6	8	272	0	244	369	3	306.90	24	83.25	CHANGED	SRKuKKAWRKNlDls...-V-psL-chR.-EcIpGGs..luEKss--LFslDopuss.......pltptppp+hpKPLK..scpIL...ps+Splsulss++ppssps.............p+.+pp.lscc-htRLtplspcppstpsph.ssp................aDlWucpss.p...................thshsphshtpss.pslK.tPhplttss....t..lP.ulchscuGtSYNPohE-appLLppttccElctEK+cpchc+ppppthpths........h...t...psh.Esp....-s-scscs...---st..t.-u-h-....sh.stpc.sc+KT+sQRN+p++cKctc+ptc...hp+phKpcppplt+l+uItcclsp+ppphscppcpcp....pcsccpth+p++L.GKhch.-tslEVhLsDELssSLRpLKPEGNLLcDRF+oLQ	.......................................................................................................s+ptK+sWRp.hp.....-lpphhcp.p.pp.h.....hG...htph.sp.pLFhlD.t.pt.............................hh.h.h...+.L+...sp.ll...tppot...l.s....t.ht.t........................................p.t....pp..h.p...h.....th....tt..........pt...t........................................hDhWsptt..t..........................................t....h............h...t.......thp....s.phttps............................h..slphstsGtSYNPshpsapphlt.p.t...hph.....Ehpt.c.pp.phpc.......h....hht......................................................ttp.................ptttt.t............tppp.t......p.sthp..........h.t...ht...sc+...KT.ctpRp+.tct+....p.ttttt......t..pt..h+..tp........ppl..p.lctlttpl.tpct...tthttht.tpt............tptpttt......p.......ppL....G+h.........ph..t..sl-l.Ls-ELs......sS.LRpL.KP.pu.slhtDRh+sh...................................................................................	0	86	136	203
+7599	PF07768	PVL_ORF50		PVL ORF-50-like family	Fenech M	anon	Pfam-B_8834 (release 14.0)	Family	This is a family of sequences found in both bacteria and bacteriophages. This region is approximately 130 residues long and in some cases is found as part of the PVL (Panton-Valentine leukocidin) group of genes, which encode a member of the leukocidin group of bacterial toxins that kill leukocytes by creation of pores in the cell membrane [1]. PVL appears to be a virulence factor associated with a number of human diseases [2].	21.60	21.60	21.60	21.80	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.90	0.71	-4.10	6	423	2009-01-15 18:05:59	2004-07-28 11:12:33	6	1	235	0	5	197	0	113.60	54	91.85	CHANGED	IlplpsK.PhKaspaE...tElhcKpGIosGlVppRV+sGWchpEAl-APhGh+LsEY+EhphpctlcptphEREhtRcR..........R+EAEL+RK...KPHLFN.VPQKHPRG+Yssah..h.NphF.+Khpc	........................................IVpIpsK.PY+FocaE....ELIEpaGITsGMVuKRVK.c.GWcLcEAhcAPcGhRL..uEY+Ehhphc...hl...Ep.tchERchtR...cR.............++EA.ELRRK...KPHLFN.VPQKHsRs.Y..ah..h.NphF.hKhpc............................	1	3	3	5
+7600	PF07769	PsiF_repeat		psiF repeat	Fenech M	anon	Pfam-B_8872 (release 14.0)	Repeat	This region is approximately 35 residues long. It is found repeated in a number of putative phosphate starvation- inducible proteins expressed by various bacterial species. psiF (Swiss:Q7AH28) is known to be an example of such phosphate starvation-inducible proteins [1].	20.70	20.70	20.70	20.70	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.57	0.72	-4.41	35	1450	2009-01-15 18:05:59	2004-07-28 11:13:55	9	3	719	\N	184	570	34	34.50	64	64.33	CHANGED	A.ssQQpKMpsCNupAssKsLKGD-RKsFMSsCLp	............s.LTPQQQKMpsCNpQATsQuL....KGD-RKsFMSsCLK..	0	17	67	127
+7602	PF07771	TSGP1		Tick salivary peptide group 1	Fenech M	anon	Pfam-B_2333 (release 14.0)	Family	This contains a group of peptides derived from a salivary gland cDNA library of the tick Ixodes scapularis [1]. Also present are peptides from a related tick species, Ixodes  ricinus. They are characterised by a putative signal peptide indicative of secretion and conserved cysteine residues.	20.00	20.00	20.70	20.30	19.60	18.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.95	0.71	-4.23	8	125	2009-09-11 03:26:28	2004-07-28 11:18:23	6	2	12	0	13	126	0	108.80	37	87.82	CHANGED	MthTslTLVLVSLAFFuoAAAcsCpNGTRPAS-pNREGCDYYCWNssTsuWDcaFFtDGEsCFYNsGscGsCpsGcCHLsT..sSGsPocssDasspPo.......ptPKpKKKKspKsKKPK+poc.KD	.........................................thh.hhhsL.V.sl...AF...hs.......s..uAu.c....s.....Cpsus..R..P.uu.cpsR...-GCcYYCa.Ns.t..T.....suW-p.h.FF....s...sGEpCaYs.s...Gp.c..GhC....ps.....G...t....C...Hhss...........suusPs..-s.s.p.ss..sp.........p..............................................................................	1	13	13	13
+7604	PF07773	DUF1619		Protein of unknown function (DUF1619)	Fenech M	anon	Pfam-B_8790 (release 14.0)	Family	This is a family of sequences derived from hypothetical eukaryotic proteins. The region in question is approximately 330 residues long and has a cysteine rich amino-terminus.	20.90	20.90	22.10	21.20	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.56	0.70	-4.61	16	255	2009-01-15 18:05:59	2004-07-28 12:10:45	6	8	95	0	139	257	1	242.40	26	46.65	CHANGED	CsCDLohuhCDlNCCCDpDCsss.stphF.thCh.tshsss.....pphCsp.ppsppopshp..........hsphssshhClhpoNpp.............ssh.shhtpsssss........shsthsps.stsssssthYchGDPlhh..........t.pssuhhplPsshss.utCs....spsVtFLpshs.osCs......hsthp....th.hsphsshhllsssp...........sss.h.hslphshtpshsthlss........sphhs..spsptCsssVlplchphhassss.l.thplhhhtuplshps...tshltpcFplp...Fhpts.ts.ssshSGNsGYlsGpP	...............................................................................................CsCDLpsstCDlpCCCD..DCs......hpl....F...p..........C.sssht.ss..................p.hCst..phh.hs..s..................t.s......hhClp.ss.p...........................sh.t...hh....p.s.ss.shp...................s...h...t..t......t....ssshY.c.Gssl.s............................uhhp....hPtsh.hs.u.Cs..p...........ssPsu.F.......L........s.s..spCsh......t..............sLp.h...t...h....s.....lhth.t..................t.h..pl........hpphs..t.hht.............................................................t.phstsll.phpY.h.hs.....s...s........t.ltphslphh.spl.............s.t..............................lpQ..pF..lp............F...p...s.......................hSGsPGY.hGhP..............................................................................	1	43	51	85
+7605	PF07774	DUF1620		Protein of unknown function (DUF1620)	Fenech M	anon	Pfam-B_8944 (release 14.0)	Family	These sequences are mainly derived from predicted eukaryotic proteins. The region in question lies towards the C-terminus of these large proteins and is approximately 300 amino acid residues long.	20.70	20.70	25.40	23.40	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.37	0.70	-5.08	35	334	2009-01-15 18:05:59	2004-07-28 12:12:07	8	9	278	0	229	324	4	207.20	36	23.50	CHANGED	hsENWllYoYass.........shhphplsllELaEsppsssptsh..............tphoSh........ss.shstllspsalhs.p.tIpphulTpTcpGITsKplLhth.sosplstlP+.lLssRR......sppssss-.pcEth.hsYpshlshss.phhloHppplhshc....................pllosPotLESTollhuaGh..DlFhTR.lsPStsFDlLscsFsK.htLlhTlluLhlsshlspshsppKplpttW	............................................uENWll...YpYass..........................ps+c.clsllELYEusp.t.tspssh..........................SSh......................sps.hP.pVhpQ.oYlhP..p..sIsshtsTtTcpGITo+plLlsh.tostIlulP+..t.lLDPRR..........P..ptsot...........pp..pEEsl.lPYsP.l.lps..ct.hl..saspsV.tl+............................sIhouPo.tLESTsLVhAaGl..DlFhTR.lsPSppFDlLp................csFsh.hhlhhslhuLhhushlsp.hsppKtlpptW.................	0	81	130	191
+7606	PF07775	PaRep2b		PaRep2b protein	Fenech M	anon	Pfam-B_4098 (release 14.0)	Family	This is a family of proteins, expressed in the crenarchaeon Pyrobaculum aerophilum, whose members are variable in  length and level of conservation. The presence of numerous frameshifts and internal stop codons in multiple alignments are thought to indicate that most family members are no longer  functional [1]. 	19.20	19.20	20.10	20.00	19.10	18.70	hmmbuild  -o /dev/null HMM SEED	512	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.70	0.70	-6.29	15	107	2009-01-15 18:05:59	2004-07-28 12:13:36	6	2	6	0	61	113	0	199.00	21	57.96	CHANGED	LcAlsPtLPtLacLRDALsEFADAF+sVTtEsl++KaGl-huYDVRNEpFFKKL-EllsMsE-YVY+NlsVERsPLDsSGphPKsVIRFKLs.GEElAHIslYWTGpcLpApFsGSREpAERLASII+ALGGcAEVKch.GstWhVpLTTDGIsAIRHsuWLsAVRuFV-ELac......KGLIuc-RY-pLl+-IEAGPNsVKaAGVEFSVhYc....t...s+pIhlcYpPpSEsoKNAAVsALKA+GL+EGVHFTVpc.Gu..YEIRVstE.YsKAlEsLspsGL+cGEaYul.s++RhIpVKs-pKDsllNALKsAGLtEG+cFss+.sG.YhIhITYDGLREIQRMALsGDhEAERFIRcLEDVL+RRaGpsAlpKLhEVLpPAREEGTlD.LPLsVhD-+GNllARVVDLKYEFVc........sspPVspCAGE-CRLRllVEYEs.uGER+QFKhEWYWtc.pcc+GpsTlTYYaEhAtsslKs-VEAAVLKALTG....KuKRGpVhLhAcpL-ALpRFKuL+DA.lDpWRsu+P	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	46	47	47
+7607	PF07776	zf-AD		Zinc-finger associated domain (zf-AD)  	Guo J, Finn RD	anon	Pfam-B_14442 (release 14.0)	Domain	The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold.  The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.03	0.72	-3.98	98	2455	2012-10-03 11:22:52	2004-08-16 09:21:17	10	977	74	1	1809	2536	0	74.80	20	13.71	CHANGED	hCRlCh......................pppsphhslhppt..........pst........plsphlpphhslplp........ts-shsp..h.lCpsChpplpphhpFcppspps.pphhpph	.......................................hCRlCh...................................pptph..hs.l..aptt............................................ttt.....................plsphl.p.p.h.s.s.lplp......................ps-..slPp......t.lCppChpp.lpph...h....p....F+ppshpspphlt..h.....................	0	336	502	1534
+7608	PF07777	MFMR		G-box binding protein MFMR	Fenech M, Bateman A	anon	Pfam-B_5000 (release 14.0)	Family	This region is found to the N-terminus of the Pfam:PF00170 transcription factor domain.  It is between 150 and 200 amino acids in length. The N-terminal half is rather rich in proline residues and has been termed the PRD (proline rich domain) [2], whereas the C-terminal half is more polar and has been called the MFMR (multifunctional mosaic region). It has been suggested that this family is composed of three sub-families called A, B and C [1], classified according to  motif composition. It has been suggested that some of these motifs may be involved in mediating protein-protein interactions [1]. The MFMR region contains a nuclear localisation signal in bZIP opaque and GBF-2 [2]. The MFMR also contains a transregulatory activity in TAF-1. The MFMR in CPRF-2 contains cytoplasmic retention signals [2].	20.50	20.50	21.70	20.80	17.60	18.10	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.75	0.71	-4.37	23	187	2009-01-15 18:05:59	2004-08-16 09:23:41	6	6	41	0	63	170	0	162.00	36	47.29	CHANGED	MGs.uE-spss.c....spPss...p.....s............psssssY.PDWuu.MQAYYus......s.PsaF.ssl.Auu.s.PHPYMWG.sQ.........MMPPY..GT.P..YsAhYP..GGlYA.HPuhP.us.s.s.h.........stss...sssshoh..Es..sKuopsK-+sshK+.KG.s.....sh.hottsspssKssu.usspshSp..........u-Sus..-GSS.pGSDuN.opsss	......................................................MGs.s-.sps.K..........pcssss..p................s......tsss..sa.PDWus.hQAY.s...................ss.saa.ssh..Auu.t.sHPYMWG..p.....................hhP.PY.Gs..P..Ys.AhYP...GulYA.HPuhs.s.......................s.........sssshuh..Es..uKsstsp-ps.hK+.Ks.......sh.hsttsspssKssusoussthSp.............................spSss..-uoS.-uSDtNopt..t............................................	0	6	35	50
+7609	PF07778	CENP-I	Mis6;	Mis6 	Wood V, Finn RD	anon	Pfam-B_17323 (release 13.0)	Family	Mis6 is an essential centromere connector protein acting during G1-S phase of the cell cycle. Mis6 is thought to be required for recruiting CENP-A, the centromere- specific histone H3 variant, an important event for centromere function and chromosome segregation during mitosis [1,2].	20.00	20.00	21.60	21.60	17.90	18.80	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.72	0.70	-6.31	5	194	2009-09-11 09:41:59	2004-08-16 09:25:22	6	6	139	\N	135	181	0	357.00	25	61.93	CHANGED	MSs.cts+Nopt..R..QsppS.QTsL.sW+httpssspKsh..cupu..LuDpcHssDQ...DuLppAlsYFEKusc+sSpsKcolLcKHLcTlEsVAacsGLsPEuIDlLLDVALSGK..FusAlsTRILKCLIPsotISEDSVVKuVSWLCVG..KCSusIQlLFLRWLIsMFDFID+KcQlspLYGlFFshLsD-sLCPYlCHLLYLLTKKENVKPFRlR+LLDLQuKMGM..QPHLQALLSLYKhFsP-LISlSLPsRKKsaFKNuDs.W+AALpAV+QRNpussP-Pp.+LhLGssss+SpKRKWNppSlIPAlsos+..h.sttK.MSh.D.husssSaPLEQLpSFPQLLpNIH+LEFPSQMuSVLsssLLLHYlNCs+DEslLLRLsYWLoQTLQEECsWhsssNsQcEcEFpsFLDhll+upCFLQEGF.SCEsFLYKSLPLWDGhsCRSQhLpLVoWIPhSoFSElKslLLDcLAQLFFTSolYFKCSlLpsLK-LLQNW.LpWLS.-lplpShosSPh	...................................................................................................................................................................pt...ht...h..ht.ltphAhppGl.sp.lp.Llplh..hp.p....hsp...ss.s.pll.K.sh.hP.s.p..h..lsppslhpslshLs.s.............KsS.shpshhh+WLlhh..a..c..hl.-....pp..p.lp.thY..uhhF.s.Lp..sl..p..lC+L......L.l..l............T+.+cp..................V....+s.......aRlptl....hpL......tph..G.....p..tL.uLLplaK.ahPpll...........sh...s..h...s.....th.t..h.F+p.c..Wptt.h.tlp....pp....p..........t...........s.......ht..........t..........s.tt...+..p.......h.lPshpo.p.......................................s.ppt.h..slEplpsh.phlpplcplE...hPsQhsuhLtsslh...+hl.hh...sp.h....Rh..Wltthhp-.................tt........t...p.tpp.h................hLphlhph.phh..pph..sh.tFhh.p.L.hWsG.p.ps.hltllpahPh.....s.pphh..hht.Ltthh.hsss.....phtllp.hptllppa..h.................h............................................................................................................................	0	27	59	102
+7610	PF07779	Cas1_AcylT		10 TM Acyl Transferase domain found in Cas1p	Anantharaman V	anon	Manual	Domain	Cas1p protein of Cryptococcus neoformans is required for the  synthesis of O-acetylated glucuronoxylomannans, a consitutent of the capsule, and is critical for its virulence [1]. The multi TM domain of the Cas1p was unified with the 10 TM Sugar Acyltransferase  superfamily [2]. This superfamily is comprised of members from the  OatA, MdoC, OpgC, NolL and GumG families in addition to the Cas1p family [2]. The Cas1p protein has a N terminal PC-Esterase domain with the opposing Acyl esterase activity [2].	27.30	27.30	28.90	31.10	24.90	23.70	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.78	0.70	-6.03	8	235	2012-10-02 17:00:17	2004-08-17 10:03:26	7	11	127	0	174	248	4	389.60	33	62.91	CHANGED	-hhph............sDGTCCpshcssTslQtlshshlhlsh.hhhh...hhhhphs.thpspshhsshp..pp.ttt..tp............suhpslhsuLspLGLIMAYFYLCDRTshFMKENKaYochsFalPllYlhVLGLFasEso+.-TKVLNRDQTDEWKGWMQLVILIYHhoGAS+lLPIYMaIRVLVAuYLFhTGYGHFoaaWp+GDFG..hhRlsQVLFRLNFLoVlLChsMsRPYQFYYFVPLVSaWahVlYsTLAlsPplsupsspsN.h.ahhLLlKlsshhshITlLhhSpshFEclFslhPLctlFsl.cssl+EWWFRWpLDRYlVaaGMlaAhhaLthQ+tplhD-sptssLhSpp.ht..hlllullullsYhsashsCcsKh....pCNElHsYluhlPIluFllLRNIoGhLRSpYSoaFAWFG+ISLELFIsQYHIWLAADT+GlLVLIPGsPsL..........NllloTaIFVClSHEVuplTspLsphhVPpDtppsh+phh..hshFsus	..................................................................................................h..............................................................................................................................t.hh.uhsphuhlhhYaYhCD...................RsshahcppK.Ysc......Fh.h....h.h.h..lh....s...h.u.h............h.h.c..............p..........p..................p......p...............t..t..........h........LNRcQT-EWKGWMQ..........llhLhYHhh...uAsp.....lY.tIRl.hlAuYlahTGaGpFoaaah+.tD...Fu....................lhR..........hsphhaRLNFhsshhCl.shspsY.hYYhsPhhohah....hhlY.s.slulhsph...sptt................hhhhKlhshhhh........lhhl.h....s.........hF-hl....a......h....phhh........t.......h....p.......s.........p.........lpE.....WhFR.tLDRa.hhhhGMlhAh.........ha.t.......h.....p..c...h.................c..t.........tt................ht......................t....h...........hhhhu.l.hs...h....h.h.Yhh.a.t.........h...p.sKh....phNp.hHPah.ShlPIhs.........alhlRNhst.hRsh...shFA...WhG+loLEhal...QaHIW.....L.............t......u......s..s......+h..lLsl........l.P..s...shl.................Nhhlsohlalhluacl.phTs.Lt.hhls.p.p...................hhhh.........................	0	79	106	146
+7611	PF07780	Spb1_C		Spb1 C-terminal domain	Fenech M, Bateman A	anon	Pfam-B_5001 (release 14.0)	Domain	This presumed domain is found at the C-terminus of a family of FtsJ-like methyltransferases. Members of this family are involved in 60S ribosomal biogenesis, for example Swiss:P25582 [1].	25.00	25.00	27.40	25.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.54	0.70	-4.85	35	314	2009-01-15 18:05:59	2004-08-17 10:07:12	7	9	273	0	235	323	2	238.50	34	30.26	CHANGED	pssscc-s-hE.................h..ttt.tpttc...................................chh...........................sAEshuLuppls.sKKo+cDLID-uaNRauFpD.....cp...sLPcWFl-DEp+HsK.phPlTKEtstthKp+h+tlNARPIKKVtEAKuRKKhRuh+RLEKh+KKAssls-ss-hoE+-KucpIp+LhcKss+ppp+ppp......plVVA++s........spshsuRPpGs+G+aKhVDsRhKKDhRAhKRht...K....K	....................................................................................................................................................................................ttptpps.......t.-.................tttt.t.p.t...t.ptttt...tt...c..........................................phchh.......................................................ssEuhALuppls.ucKs+c.DllD.suaNR.YsF.pD..c-........sLP-WFl-DEp+H...p+.phP.lTKctstth+c+h+tlNARPIKKVtEAKARKKh+shp+LEKh+KKuphls-sschoE+-Kspplp+lh+K.As.pp.cp+pth......phVVA+ts........spt.hstRPpG..l+.G..+aKhVD..sRMKKDhRAt++ht+.t..............................	0	87	135	197
+7612	PF07781	Reovirus_Mu2		Reovirus minor core protein Mu-2	Moxon SJ	anon	Pfam-B_9308 (release 14.0)	Family	This family represents the Reovirus core protein Mu-2. Mu-2 is a microtubule associated protein and is thought to play a key role in the formation and structural organisation of reovirus inclusion bodies [1]. 	25.00	25.00	280.80	280.50	16.90	16.50	hmmbuild  -o /dev/null HMM SEED	735	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.18	0.70	-13.19	0.70	-6.56	5	53	2009-01-15 18:05:59	2004-08-17 10:08:56	6	1	24	0	0	56	0	726.00	44	99.09	CHANGED	MAYIAV.PsltVuSRsTsLlsoIDuhsscsst-tpDVushDPoalLRQLEhhSuGhosuDllcALlH+cWh+poshsLLPs++pLL-YLLSNPSAsPDslDRopLKuhhhpK+hssD.........F+IpDaauPLIosSTuluThoRpLNAuplVYosTsKVlGARL+LaAPAKYYuuoLSsppppuIlPSoccltssP+uRlsVosFPSloTs+CFVLouVDt.ssPsh..sVcaIQLhYpRshuV+ARhLsD..PlAluchlscpuLKsphssPoDA..RAARLstlRsputosPsGlNsStlsVVDLphph.ssscuLtsVsRsh+LTlHuVPSCLLphL-ITluDc.YPIRpEoGMFssWFLlLTLhSDclTDuRT+puVhLpPuSsuscslsaVplsusVSsRspSVtussusalcuVGLsLPKGSFKSTMI+sLsuLpIsGspVM.ussVlDSD-VGDSLcPTFETA...lY-tLtuLDP..lDDllKlALuTDLlsp-ssloplasoFLcLssELLTPtARchYspposEGRoLTFAHADSEhLNANasu+LlRstIPYacEVNILlRPNRVGGsLFQVlLSYCYKMaATSssosPhGtLLKpLFsPWLcussLlusLsPscoSAsluWaIPuchhsssGWChC-D.taloas.IRuhPL-lSVLctacWuRa+AsIlV-co.....LVplGuDhRssthuVhassatPsVcLlophAsFTLss+YclpL...........sCusooGRsasAcNs+LsloosG	..........................MAYlAl.Psl.VsSRposhlshl-uhs.lcsth-h.sDVthhD.shlLcQl-hhssGhpssDlhcuLlH+sWh+pSlhsLLPs+ppLLEYhhSNP.S.uhPDslDRphLKth.......Kch.pD.........F+lpDaauPLIosoTShhThsphLNst.IVYoTTc+VlGARlpLauPtKYYsho..uhhpphsIl..scclhsVPpuRhhVGsFPShuTspC.VLouh-h.stPsh....hchIpLhYp+.hp.VpAphLsD..P.lsuhhlsp+pl+st..sPs-t..RAAR.htlphp..stsssptlssthlpV.VDlhhph.sstcuLhsspR.h+LThhuVPsClLphLslp.luDt.hsIRpEsGMFs.WFLlLThhSDtlpDsRsp.tlhlpPSSssspsl.plplTuhlst+s.slhsshhsh.lcsIGlshPKGSFKSThh+hLsulpIsGsp.lM.pssVlDSD-VGDsl-PTFEpA...lYcult.ulDs...-DlhKhshsoDLlsp-.hh.uplassFLtLsp-LLsPhARchYspphsEuRsLTFAHADSEhLNAsasu+LhRshIsYhpEhNlllRpsRlGGsLFQllLShCYKMaATSssspPhu.hL+tLhsPWLcst.LluphsPspoSt.luWaIPsphhhpsGWCsC-c..talsas.IRu..hslp.LphhsWupa+Apl.Vssp.....LV.lGtshRssthuVhhssphP.VclhsphAhFT.ht+YchpL...........pCspusGRs.tAhNh+Lhhpo..................................................................	0	0	0	0
+7613	PF07782	DC_STAMP		DC-STAMP-like protein	Fenech M	anon	Pfam-B_9122 (release 14.0)	Family	This is a family of sequences which are similar to a region of the dendritic cell-specific transmembrane protein (DC-STAMP, Swiss:Q9H295). This is thought to be a novel receptor protein that shares no identity with other multimembrane-spanning proteins [1]. It is thought to have seven putative transmembrane regions [1], two of which are found in the region featured in this family. DC-STAMP is also described as having potential N-linked glycosylation sites and a potential phosphorylation site for PKC [1], but these are not conserved throughout the family.	25.00	25.00	26.90	26.90	24.50	23.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.94	0.71	-4.68	19	281	2009-01-15 18:05:59	2004-08-17 10:10:02	8	6	81	0	182	260	0	173.30	25	29.66	CHANGED	F-NhYlTctFhph-pcccchsttslLPLpppEcpphlplsphphotp..Ehhplhhphh.lhlphlthshhlhlDahlapllshlpp..........h...phps.ttlplpl.sGsuhhuclh............cphhpsFpshp...phshphss..pcC.lPpPph.shtshlhlslLhLhshhllhlpsYshRlR+lIsu.FYPpcE+cRlhaLa	......................................a-NlYITp.FhphDtpcpphtp.s.lLPLpptE..p.p..phl..spht.l.stp..Eh.hp.h.hhthh.hhhhhhhhhlhshlDahlahllphhpp.............................................php.s..hlplpl...tGtuhhuplh.............+phh.t.shsh.p...phs.hphss...pC.LspP..p..stpta.hhl..sllhhlhhhlslhpsashRLR+.llsu.a....aPppEc.cRlhaLa...............................................................	0	45	59	112
+7615	PF07784	DUF1622		Protein of unknown function (DUF1622)	Fenech M	anon	Pfam-B_9062 (release 14.0)	Family	This is a family of 14 highly conserved sequences, from hypothetical proteins expressed by both bacterial and archaeal species.	19.90	19.90	20.50	20.50	18.60	19.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.37	0.72	-4.33	51	422	2009-01-15 18:05:59	2004-08-17 10:21:47	6	2	358	0	127	289	25	80.30	35	64.72	CHANGED	Gslhuhh.......phlttthtpp.......stsa.....p.plRhplGphllLGLEFhlAADIlpTsl.sPohp-lhhLusIllIRThLuYFLs+El	..........................Ghhhuhhphlp..hppp.......spth.....p.tlRthLGsalLLuLEhLluADIlcTll..pP.Thp-lhhLuslllIRTlLSaFLppEI......	0	44	91	112
+7616	PF07785	DUF1623		Protein of unknown function (DUF1623)	Fenech M	anon	Pfam-B_9100 (release 14.0)	Family	The members of this family are all derived from  relatively short hypothetical proteins thought to  be expressed by various Nucleopolyhedroviruses.	25.00	25.00	61.90	61.60	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.17	0.72	-4.03	13	31	2009-01-15 18:05:59	2004-08-17 10:24:15	6	1	30	0	0	26	0	87.60	39	88.90	CHANGED	LoAaVLhVsNs.sh...p.p.hYhthLc+asVlDulMCs.NGDCLAVslossshhsp...............p.ppLcll-...pas.psl-hLh-KIYsIV-hYN	.LhsaVlhlsNs..ch...p.p.IY.pYLp+asVlDulMCs.NGDCLAVsVossshlpp.....................psLcll-...pts.psl-hLp-KlasIlEhYs	0	0	0	0
+7617	PF07786	DUF1624		Protein of unknown function (DUF1624)	Fenech M	anon	Pfam-B_9180 (release 14.0)	Family	These sequences are found in hypothetical proteins of unknown function expressed by bacterial and  archaeal species. The region in question is approximately 230 residues long.	20.60	6.20	20.60	6.20	20.50	6.10	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.62	0.70	-5.01	49	1276	2012-10-02 17:00:17	2004-08-17 10:26:21	7	9	944	0	477	1471	482	201.10	17	57.55	CHANGED	RhhtlDhhRGlAllhMlhaHFsaDLpaFGhhshsht.sshathhup.hlAshFlhluGlSLsluhspshph..........ppah+RhhplhuhAhlIossTa....l..hhP.pual.hFG..................ILHhIu....luslluhhF..h+hshhshhhhuhhhlhh........shhhtt...................hhsss.....hLhWlG....lhs...tsh..ho.DYhPlhPWhGlhLhGlshuphhh.p...tpht...hst.hhhtsLsh.l..GR+SLhl..YLlHQP	...........................................................................RlhslDhhRGls.llhMll......s...p....h......h.....h.................h..........t......................h..h.....h...............h.........................t.....h............................................h.......h....h..h....h............sp....h...........s....h....sh..Fl....hls..G..h..ohh..l...h..ht.p.t.th................................................tth.h..p....R..s..l.....h...l.....h...h...h..u..h..h.....l.s.h.h.sh.................h......h.hs......ph....l....hh...s...................................................................................................l.Lpt.l..u....l.s....h..l...l.s.h....h....h............hp.h......h....h....h....h.h..h.h....u..h.h.h..hh.h..........................hh.....................................................................hh.t.................h.......hh........h.......................................s..............h........sh.h.......s...hh.....sh.hhhGhhhu..h.h................................................................................................................h..h..................................................................................................................................................................................................................................	0	161	323	402
+7618	PF07787	DUF1625		Protein of unknown function (DUF1625)	Fenech M	anon	Pfam-B_8907 (release 14.0)	Family	Sequences making up this family are derived from  hypothetical proteins expressed by both prokaryotic and eukaryotic species. The region in question is  approximately 250 residues long.	20.30	20.30	20.30	21.00	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.49	0.70	-5.13	22	173	2009-09-11 05:28:20	2004-08-17 10:32:38	7	4	130	0	114	183	5	235.90	27	61.61	CHANGED	MYQWVEppppcp.pp.ss..p....oYpYsppWpsphlsSppF.t.pGHpNPss.h.lpupshhs.pV+lGsahLupslhpplss.hcslshss................pssttphphpsshhYhsps.stpPpl.....................GDlRlpFphs............ss.sollucQpss......plhPapopss............................................ppl..hlh.GphoscclFp...pttppsshhTWhhR..hsGalLhFlG..hhhhhs.lthLsshlPllts.............lsshshhlhu..hhluhslsLhsIAhuWlhYRP	...........................................................................MYQWlEppppcphpp.stt.p...........ppYpYsp-Wpschls..SppF..ppthGHp............NPs.....t..hslcSh..shhAstVplGt.ahLusslhcchss..hptls.h..sp...........................................ps.pssl.ph....psshhYaups...stpPpl.............................................................GDlRlpFphu...............ss.ph.soVl..u..cQ.p..us........plhP.ap..opsG.....................................................pplh.ll..t..Gp...h..oscchFp...ppp...pssshhTWh.hR...hhGahhhFh.G..hthhh....ph....lhhlh...s...hhPh.hts................lsshshhh....hs...hhhuhslslhsluhuWlhaRP............................................................................................................................	0	49	66	89
+7619	PF07788	DUF1626		Protein of unknown function (DUF1626)	Fenech M, Sammut SJ	anon	Pfam-B_9705 (release 14.0)	Family	This is a family consisting of sequences from hypothetical proteins of unknown function expressed by certain species of archaebacteria. One member (Swiss:Q9YCN7) is thought to be similar to tropomyosin [1].	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.14	0.72	-4.19	18	128	2012-10-11 20:44:44	2004-08-17 10:41:17	6	6	56	0	61	129	12	70.70	35	27.66	CHANGED	ScVElDlllKDGplIllEIpSSlpRGDlhhlcRKs-LYE+scuhKhs+llllTPaI--R....s+thAcclGIc	....pplElDl.ll+sGhhlllElKSulc+uDl..h....htRKschYE+.hps++ss+l.llloPhlcc+....uhthAccLGI-..............	0	26	36	45
+7620	PF07789	DUF1627		Protein of unknown function (DUF1627)	Fenech M	anon	Pfam-B_9837 (release 14.0)	Family	This is a group of sequences found in hypothetical proteins predicted to be expressed in a number of  bacterial species. The region in question is  approximately 150 amino acid residues long.	25.00	25.00	27.80	27.10	24.10	23.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-4.68	4	472	2009-01-15 18:05:59	2004-08-17 12:03:29	7	1	171	0	4	267	0	143.60	65	64.12	CHANGED	IEQ+GPQTADELAshFGsTSRKVASTLAMAISKGRLIRVNQsGKFRYCIPGsNLPAEPKAASVocsDGKAFPQPsGsALPVtEAATQE-IKTEoVAslVQs.PSFTcppsDtLlhPSL+hANhtLRRAKspVQKWERVCAALRELNKpRDIlRpI	...........................................ItQcGspTs-ELAshFGlo..oRKVASoLAhshupGRLhRVNQsGKFRYCh...P...G...ssLPAEP.KAAsVs..EoDGKAFPQPA.GsALPVpEAAT.QE-IKTEoVA-hVQshPSFT..cs.ps..DsLILPSLHhANRELRRAKupVQKWERVCAALRELNKHRDIlRpI.......................................	0	1	1	2
+7621	PF07790	DUF1628		Protein of unknown function (DUF1628)	Fenech M	anon	Pfam-B_5107 (release 14.0)	Family	The sequences making up this family are derived from hypothetical proteins of unknown function  expressed by various archaeal species. The region  in question is approximately 160 residues long.	24.20	24.20	24.30	24.60	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.96	0.72	-3.23	48	295	2009-01-15 18:05:59	2004-08-17 13:02:07	6	14	62	0	237	307	97	81.90	25	31.71	CHANGED	cAVSPVIGVlLMlulTVIlAAlluuFlhuh....ssspssPp.ssl...........p.p...hssssst...............lplpHpGG-slss...pslplh...lsssss	.........puVSPVlGVlLM...lulTVIl.AAllus.as.huh.....sss.sppsPp..ssl.......................................php.........hssssst....................ltlpa.tG.G.-.s.lsh...pplplhh.....s....................................................................................	0	40	200	223
+7622	PF07791	DUF1629		Protein of unknown function (DUF1629)	Fenech M	anon	Pfam-B_9012 (release 14.0)	Family	This family consists of sequences from hypothetical proteins thought to be expressed by two members of the Xanthomonas genus. The region in question is 125 amino acid residues long.	22.10	22.10	23.50	24.80	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.58	0.71	-4.24	13	56	2009-01-15 18:05:59	2004-08-17 13:46:31	6	1	29	0	16	57	1	119.60	48	57.33	CHANGED	ctGEFahLcsDhcusGsspGVVFENc+pLLoPPRLILRPc-GGFPsLREpP+LsY-PspGs.PcDLEuGFSGYWLVSERL+pVhtuVDP-AFAFA-sDaRLADGopGPRaaLCDVVRpLDALDE	.....................................GpFahlpssh.tst.spGV.FpN.cpLlsPsRlILpP.c.pGGFP..sL+EpP+LlYcPscGs.P.cDLEsGFSGYWLVSERL+pVhpsVDPcAFAFA-sDaRLAD.G.o.tGPcaaLCDVVRpl.DALDE.	0	2	5	8
+7623	PF07792	Afi1	DUF1630;	Docking domain of Afi1 for Arf3 in vesicle trafficking	Fenech M	anon	Pfam-B_9160 (release 14.0)	Domain	This domain occurs at the N-terminal of Afi1, an Arf3p-interacting protein, is a protein necessary for vesicle trafficking in yeast. This domain is the interacting region of the protein which binds to Arf3, the highly conserved small GTPases (ADP-ribosylation factors). Afi1 is distributed asymmetrically at the plasma membrane and is required for polarized distribution of Arf3 but not of an Arf3 guanine nucleotide-exchange factor, Yel1p. However, Afi1 is not required for targeting of Arf3 or Yel1p to the plasma membrane. Afi1 functions as an Arf3 polarization-specific adapter and participates in development of polarity. Although Arf3 is the homologue of human Arf6 it does not function in the same way, not being necessary for endocytosis or for mating factor receptor internalization. In the S phase, however, it is concentrated at the plasma membrane of the emerging bud. Because of its polarized localisation and its critical function in the normal budding pattern of yeast, Arf3 is probably a regulator of vesicle trafficking, which is important for polarized growth.	25.50	25.50	26.00	25.50	24.90	25.20	hmmbuild  --amino -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.76	0.71	-4.18	31	156	2012-10-02 14:18:06	2004-08-17 15:51:17	7	6	144	0	117	210	0	149.80	36	19.68	CHANGED	pV-YILlApFDlD+GPlhcHQYPssl.sG..............sEphLAcLMLPDpsHsR.sp...DaTlFhLacss.spt.p...........ttt.......................pt.t......................................p.....tt....s.hahlsllpsptDpshcRGuhlKuhAlsTphshlaha+..sllhhsL-	............................................pVEYILlApFDlD+GPhhcHQYPssIsG...................................DEphLAE.......LMLPDpsHhRsp.....DWTlFa.La+sssspptp.............................t............................................p..................................................................................................sppptpsscs.....sshhYllNlVs.sppDpos+RGAhlKuhAIsTphsahplaKPlLllsL...............................................................................................................	0	42	72	103
+7624	PF07793	DUF1631		Protein of unknown function (DUF1631)	Fenech M	anon	Pfam-B_9170 (release 14.0)	Family	The members of this family are sequences derived from a group of hypothetical proteins expressed by certain bacterial species. The region concerned  is approximately 440 amino acid residues in length.	19.70	19.70	19.70	19.80	17.50	19.30	hmmbuild  -o /dev/null HMM SEED	730	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.13	0.70	-6.40	36	372	2009-01-15 18:05:59	2004-08-18 12:44:36	6	9	187	0	125	418	96	617.90	21	89.36	CHANGED	ssptpsst.....sphPslLhpl+-pstppLtphLpshF-ssDDsLF-hA-+Atss.p-QshaF-AMR-LRh+RcslppsFhppltpuFss.Lspspssss..shs...hs.ssLoLVppc-LEcplAlcsMls+spschstsLtpLstRLshLh.sshplppcsNPLuPptLCpsFhcAs.psLslsl+s+LlllKLFERhVlsplsplYscANplLlpsGVLPcLp.s....................................hppspsss.........sssptsssssssssspsuss.ttttt.......................................pshFs....tLppLLtpsRssttsst.ssssss............................tslssp-LhphLupLQ...........t.ssshsssp.......hslpp.lppLLpphp..spsGpppslupsD-DlINLVuMLF-aIL-DcsLsssl+ALIuRLQIPlLKVAlhD+sFFs+ssHPAR+LLNplApAuhGWsspss.htcDsLhp+lpplVpRlLs-FscDsulFs-Lhp-FptFhpp-cRRs-llEpRsp-AEcG+s+tctA+pplpptLpp+ltsps.LPpsVhplLppuWocVLhLshL+cGcpS.cWppulplhDcLlaslp.pp.pspsppplhphlPsLLcsLRpGLppl.uacshpssphhppLcphthpshps........................................................................................t.st.stpssstspss-clsssttppsttttt....................stppphlpplcpLclGoWlEhtccc.tchhRsKLuuhl.csos+alFVNRpGhKVtEtotpsLAhthppGpl+lL..Dcu.hLFDRAL-uVlssLR	..................................................................................................s..................h...t.hht.hh..ht.hh.thhtth........tpt....Lhp.upputss...pt.h...hts....h....ptl.c.....pt....tth..t.thhtth.pthtt....h.t.t....t................t.ttL......sLltpppl-pplhlpthstth.pp.t..L.t.Lp.tRlshlh.......thttpp.PhtPthlsthhhpsh.tth.s.lt.p..sphhlhchhcp.lhtt.hsthYtphsphLhttGl.hP.t.h...................................................................................t....t.t..................t...t.....t.......s..............................................................................................t.hht.....tlpthht....t...htt............................................................................h.s.tttlhp.h.Ls.tlQ...............s...tt....................h.tt..htp.llpt..........tp.t..tthls..-pss.....ls...........lluhlFp.lhp-tplsssh+shlu+LplPh.l.+.l.AlhD.pF.FsptpHPARcLLsplupsshuhss.pss...t.p...ptLhtc..lpphVpp...lhp.pap.p.s..slFt.p...h.t-ht.t.a...h....p..........p....t.tpc...sph.hpp+hhc.stc.upt+hph....Ac.....p....tstttlpp.....hh.t.st.........s....lPph...l.phLppsWtcllhh.sh.l.+..p....G......tpu....thpt..h............h..t.hhspLlhshp.tt.......tttt.tl.t.....h.stLhpt..lppultph...u.hs..tttthhppLpp..hhhtshtt.....................................................................................................................................................................................................................................................t.........t...hh.pp.hs....ttt..................................................tpthh..t.h.cplthGsWl.-h.....ppp..tphhps+Lshhs...ssphlF...ls.ppG..h+h.h.h...shttLAh.hpt..Gthphh....ppt...lh-cAhpssltt............................................................................................................	1	33	80	108
+7625	PF07794	DUF1633		Protein of unknown function (DUF1633)	Fenech M	anon	Pfam-B_9750 (release 14.0)	Family	This family contains sequences derived from a group of hypothetical proteins expressed  by Arabidopsis thaliana. These sequences are  highly similar and the region concerned is  about 100 residues long.	20.40	20.40	34.20	29.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	790	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.40	0.70	-6.58	2	28	2009-01-15 18:05:59	2004-08-18 14:02:52	6	5	2	0	0	28	1	198.90	20	84.20	CHANGED	MpRLFSAPHLTsQIRRGEEISsISKIVVMMA.LNNFP.LH.hSRQLTpLs............................................SDh-DSQNKSNHSYGDssSSS..Rst.......+RVITLGGMGPIRpPSTRsDKPKKKKAsKQtGuhPMTNsDL.................Vs.cRtstVslpl+.hLpc.................P.L+L.pNVS......sG..shYsshhtcptlhhPhPAu..........Rs+-V...............sLSthcLt..hLLhpG......................................pschuTFsRDR.VsALslsPAsPsIs.PsAQ.DPlEEVPpl..hPpA.h.h...ls.sSsSTSp........Cso..........pARAsDLSAsVsAARsoLAsSpspASsSHPSLPtsN.......................................susstAAVul...................................uAsN+.......................LlthhctR.sQVP..............oupphp.GcphhRc.sspltssp-REVp.tAc.....h.RLKhELSTSKDLEKGYAEKIthME.EFtGLpADKQhARsQIHRLpp++-ELSK+VhDLTS.AQGspKAVHDAKVELAAuY.KLLuGIK-KWVsKKEaTVLEuQAAEVESNLALIDQIsKAAlDLTlEKPRhQAElDDlEARCp.KEVSDFTLSKLDlPcVSEh.VVRPhsVDEQGTPIGLDEFGSNKDsFPtGLt-ssGTVFAhPAGtS+E	......................................h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+7626	PF07795	DUF1635		Protein of unknown function (DUF1635)	Fenech M	anon	Pfam-B_9707 (release 14.0)	Family	The members of this family include sequences that are parts of hypothetical proteins expressed by plant species. The region in question is about 170 amino acids long.	21.40	21.40	22.20	22.20	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.27	0.70	-11.66	0.70	-4.96	5	89	2009-01-15 18:05:59	2004-08-18 14:04:57	6	7	23	0	64	90	0	190.00	30	60.51	CHANGED	cThEELRQoLlYTThELEQTKMhAsEElRp+DEQlhpLcDLLsKTlKERDEApE+hp+LLhcs..L.Qpp......................pDEQlpPNp.pLspsNSFSSSDsE...ESIsSSp.psh................-PsspppLcclsss-hLh..ll.-KsLPEKGKLLQAVlKAGPLLQTLLLAGPLPQWRHPPP.LcS..FEIPPVo.....ls.tCP.hossGCG.NFN+KRVa.luDtShsETKYQR.LLc	........................................................h-EL+ppLhhsohEL-thp..Ap-Eh++pcpplhpLhcLLptshpERDEApcphppLh..htt..h.t.t.................................................pspp.......tp....pp...u..hs..s.Sssp.....pshsSs....h........................................t..st.t.......t............t...phh....hs..t+sLPpKG+LLpAVhcAGPLLQTLLlAG...........PLPpWRpPPP.hp..s..hplPsh......................................................................................................t...................................................	0	12	47	56
+7627	PF07796	DUF1638		Protein of unknown function (DUF1638)	Fenech M	anon	Pfam-B_6091 (release 14.0) & Pfam-B_3149 (release 23.0)	Family	This family contains sequences covering an approximately 270 amino acid stretch of a group of hypothetical proteins.\	  These proteins are expressed by archaeal species of the Methanosarcina genus.	20.40	20.40	22.10	21.40	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.06	0.71	-4.61	55	232	2009-09-11 07:42:39	2004-08-18 14:25:11	6	8	168	0	105	231	180	166.10	23	67.84	CHANGED	phLsu.tLHstP-clpstlppslpchp...........sth-pIhlsYus..CGsu.....Gtlppph..schG.........lhh........htuscChuhhh...Gssphttch....schssFYLTshhscpa-s..............hhhcshGhDcpspLc....phhaup.Yp+llals..........psc..............-.thppcscchAsplGLsapch.sshGsLptslpsh	.............................hLsstLHsp.P..-clpptlpptlcphp............th-p...IllsYGt..CGsu.....Ghlspthp..t.........lhh............psscChshhh...Gspphttp......pchssaa..LTs....hhhcpacs...................hhhcthGh-ct.splh.....chhaspYpcllhls........ppc......................-..htppscchAchhslshphh.sshs.Lpphlt.................................................................................................	1	44	83	89
+7628	PF07797	DUF1639		Protein of unknown function (DUF1639)	Fenech M	anon	Pfam-B_6036 (release 14.0)	Family	This approximately 50 residue region is found in a  number of sequences derived from hypothetical plant proteins. This region features a highly basic 5 amino-acid stretch towards its centre.	22.20	22.20	22.20	23.30	20.90	21.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.55	0.72	-4.57	20	205	2009-01-15 18:05:59	2004-08-18 14:57:55	9	6	19	0	117	191	0	49.90	50	19.35	CHANGED	LS+cEIEEDFhAMpGs+PPRRPKKRsKsVQKpLD...............hl.PGhhL..sclos-pY	.LSp+EhEEDFhAhpG.sK.PpRPKKRsKhVQ+pLs........................hlhPGhWL..s-lot-pY...................................	0	14	66	95
+7629	PF07798	DUF1640		Protein of unknown function (DUF1640)	Fenech M	anon	Pfam-B_6194 (release 14.0)	Family	This family consists of sequences derived from  hypothetical eukaryotic proteins. A region approximately 100 residues in length is featured. 	24.20	24.20	24.20	24.40	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.04	0.71	-4.23	24	513	2009-09-11 19:38:48	2004-08-18 16:04:56	6	13	255	0	324	490	8	162.70	26	59.06	CHANGED	hFDTpthVp.pL.Ecs...............GFsppQAEslspslscllpsulpplspshVo+tphpp.........sthpQcschucl+s-lh.......................p...............h-+oEFsslpsEpE+l+sDLc+L+s+L+-Els+spAuh+LDLNLEKu............RlR-Ehupp-hK..................lp-hss+IDpElusL+splEosKhpslpaLhGsssushAlhLuahRlhh	..................................................FDThthVp.pL.c.pt.....................................G.FsppQApslhpslpp...llpss.....l.pt...l.....t.p.s.....h.ls.+.tc.hcp......................tthp.psshuc..l+s-l.........................................................................ccsch...sth+sppc.+lpt-lpplp....p...cLpp.E.l.sc.hps...sh+.LDhNhc+u..................cl+-..stp-hc...........................l.p-hpp+I....-p........-.l.s.s....l+tt....lE....s......hKhp....sh.p.a.h....h..u.h.hs.hhslhhuhhh..........................................	0	78	163	247
+7630	PF07799	DUF1643		Protein of unknown function (DUF1643)	Fenech M	anon	Pfam-B_9851 (release 14.0)	Family	The members of this family are all sequences found within hypothetical proteins expressed  by various bacterial species. The region  concerned is approximately 150 residues long.	20.20	20.20	20.40	20.50	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.87	0.71	-4.47	57	556	2009-01-15 18:05:59	2004-08-18 16:06:40	7	5	475	0	91	385	369	133.70	33	76.28	CHANGED	RYhLpRpW.........s..tsttpllFlhLNPSpAsttpsDPTlcRh.phA.+sh.GaGuhhlsNlFAhRuTsPpsLpp............ssDPlG..sc.NDthlhchsp.hu....spllsAW.GspGt....hhsRs....ppVhchLpst.............lhpLGlo+sGp.PcHPL	...................RYhLp+pW.........s....tpc.sshhIsh.P...shs.....s....s.....hp..DhTsth.lhsh.............h.....ps.....................saG...ulhllNLFu.hp.T.Pc.sLc.c...............hp.c.Phs.....pc..sDhplhc.sls..cu.............-pVlhAW.Gs....huc.........hhpRs......ppV.h.chLcsp...................tttlhp.l.h........s.tssc..hHPL.......................................................	0	21	51	76
+7631	PF07800	DUF1644		Protein of unknown function (DUF1644)	Fenech M	anon	Pfam-B_5078 (release 14.0)	Family	This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.	25.00	25.00	26.00	31.70	24.50	23.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.89	0.71	-11.18	0.71	-4.38	18	198	2009-01-15 18:05:59	2004-08-18 16:09:58	7	4	23	0	117	186	0	146.10	44	52.08	CHANGED	-DspCPlChEaPHNAVLLhCSSacKGCRPYMCsTStRHSNCL-QF++uhsctts.sp......................................................................................t.pppc..cLsCPLCRGcVpGWpVVcp.ARpaLNpK+RoC.p-sCsFsGoYp-L+KHs+pcHPsu+Ps-lDPscppcWcpLEpcp-htDllS	................................................cspCslCh-hPHNAVLLhCSSacKGCRPahCsTshp+SNCL-..pa+puhsp.t..........................................................................................................................pppp..pLtCPLCRGpVpGWhll.c..ARpaLNtKpRsC.p-sCsFsGsYpEL+KHs+pcHPpu+PpclDPs+ptcWcphEppp-htDllS...................................................	0	18	64	91
+7632	PF07801	DUF1647		Protein of unknown function (DUF1647)	Fenech M, Pollington J	anon	Pfam-B_5249 (release 14.0)	Family	The sequences making up this family are all derived from hypothetical proteins expressed by C. elegans. The region in question is approximately 160 amino acids long. The GO annotation for this protein indicates the protein to be involved in nematode larval development and to have a positive regulation on growth rate.	20.80	20.80	20.80	21.60	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.66	0.71	-4.69	15	96	2009-01-15 18:05:59	2004-08-18 16:22:08	6	6	28	0	90	84	29	119.60	29	31.81	CHANGED	CtChSspoGKoYsFCYpsPpNssSIGKKFsCuhLsTLEcLsLlspss.phlsLssshcNpsslVFVSATS-DHhs.uhpShpSlR+aYPppKaILYuLsLocs.IppLscp.pNlEhRtFNTotYPcYVsNWhcY+FKPLllA	..........................................................Y...ps.t.hGtp..FsC.hlthh-pht..............lh...........t..t....h.ph....pp..p.spppls.hVSssSssHhtthhp.hpslppahPsp+hllYuLslspt.lpp..lt..p................p.sshchRpFshotYPpaVp...shhpYpaKslllA...........................................	1	34	41	88
+7633	PF07802	GCK		GCK domain	Fenech M	anon	Pfam-B_8992 (release 14.0)	Domain	This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as Pfam:PF00071) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family (such as Swiss:Q9LMF3); this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerisation.	23.40	23.40	23.40	23.40	22.10	23.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.78	0.72	-3.85	8	81	2009-01-15 18:05:59	2004-08-18 16:43:26	6	6	28	0	64	77	3	69.50	36	36.18	CHANGED	GECtFCpFMKGGuCKEuFlAW.EcCs.-tAccsccpDhVT+CtElpuphK+CMcsHuDYYpPlLAuEKsucs+hcKEL	................-ptashFMKuGuCK-sFhAW.-cCs.pts...pt.ptp..shhpcCt-shstLc+CMc.AHuDY..YpPlLsspcshtpph.tt........................	0	16	26	34
+7634	PF07803	GSG-1		GSG1-like protein	Fenech M	anon	Pfam-B_9727 (release 14.0)	Family	This family contains sequences bearing similarity to a region of GSG1 (Swiss:Q9Z1H7), a protein specifically expressed in testicular germ cells [1]. It is possible that overexpression of the human  homolog may be involved in tumourigenesis of human testicular germ cell tumours [1]. The region in question  has four highly-conserved cysteine residues.	19.50	19.50	19.90	19.90	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.67	0.71	-4.50	8	150	2012-10-03 00:20:40	2004-08-18 16:56:19	6	3	42	0	77	136	0	118.40	46	41.34	CHANGED	+psR+sRuLLSlsLNhLALhFSsoAhlToYWCpGTQKVPKPhC.ot...s+ppNChshssssss...................sP...............ssVpYsWETGDDRFlFRpFHTGlWhSCEEslassuc+CR........SFI...cLuPsSp+G	..........ptpRshLolhLshLALshSsoAllooYWC.GTQKVPKPLC..up...sttspChchsss.su...t.ss................sp..........................psVpYsWETGDDRFhFRtFHoGhWhSCEEsl..c..p.sG..E+CR........SFl...-LsPstcp.u......................................	0	3	12	41
+7635	PF07804	HipA_C		HipA-like C-terminal domain	Fenech M	anon	Pfam-B_8632 (release 14.0)	Domain	The members of this family are similar to a region close to the C-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis [1]. When expressed alone, it is toxic to bacterial  cells [1], but it is usually tightly associated with  HipB [2], and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with  cell division genes or their products [2].	24.00	24.00	24.00	24.10	23.80	23.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.01	0.72	-3.86	175	2174	2009-09-13 11:39:15	2004-08-18 17:00:02	7	16	1315	18	624	1916	261	82.00	26	20.24	CHANGED	Rlthpshsslhshsstp......................suat.plhphl............pp..hst............ttshpchhcphlFNhlluNsDsHsKNauhlhs....ss.s...h.pLuPhYD	........................................................Rl..pshsph..hshsst......p..................suht.pl.hphl....................tt...hs.t.s..................htch.tp.h.h.c.t.h.lFshLluNsDsHsKNaShhhp.....ss.s..................a..cLuPhYD...........	0	159	359	505
+7636	PF07805	HipA_N		HipA-like N-terminal domain	Fenech M	anon	Pfam-B_8632 (release 14.0)	Domain	The members of this family are similar to a region close to the N-terminus of the HipA protein expressed by various bacterial species (for example Swiss:P23874). This protein is known to be involved in high-frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis [1]. When expressed alone, it is toxic to bacterial  cells [1], but it is usually tightly associated with  HipB [2], and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with  cell division genes or their products [2].	21.00	21.00	21.30	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.68	0.72	-3.76	170	2004	2009-01-15 18:05:59	2004-08-18 17:04:41	7	15	1218	8	598	1762	241	83.10	28	20.04	CHANGED	SluGspsKhslhh.............................ssssspaIlKhss.sp............h.shstsEhhshp.lAp.thGl.sss..pspl....hphss................ptshhlcRFDR	........................SluGsp.Khslhh.t...........................tth.h...s...s..s.s.sspaIlKhsh.sp.............s.htshspsEahshp.lAp...th..Gl...sss...pspl...hp.hss.................tpslhlcRFDR...................	1	152	346	484
+7637	PF07806	Nod_GRP		Nodule-specific GRP repeat	Fenech M	anon	Pfam-B_8942 (release 14.0)	Repeat	The region featured in this family is found repeated in a number of plant proteins, some of which are expressed specifically in nodules formed during symbiotic interactions with certain bacterial species [1]. Some of these proteins are also termed glycine-rich proteins (GRPs), due to the presence of a glycine-rich C-terminal region in their structures [1]. Bacterial infection is required for the induction of nodule-specific GRP genes, and it is thought that nodule-specific GRPs may play non-redundant roles required at specific stages of nodule development [1]. Members of this group of proteins may be cytosolic, whereas others are thought to be membrane-associated [2].	25.00	25.00	49.20	35.60	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.09	0.72	-4.34	10	36	2009-01-15 18:05:59	2004-08-18 17:16:57	6	5	5	0	0	36	0	36.80	65	52.23	CHANGED	Gss+ESKTKhGhDGWRDWGGSFWp.DscENNGGG-KEGG	GVs+ESKTKlGhDGWRDWGGSFW-stcENNGGucKEGG.	0	0	0	0
+7638	PF07807	RED_C		RED-like protein C-terminal region	Fenech M	anon	Pfam-B_9789 (release 14.0)	Family	This family contains sequences that are similar to the  C-terminal region of Red protein (Swiss:Q13123). This and  related proteins are thought to be localised to the nucleus,  and contain a RED repeat which consists of a number of RE and  RD sequence elements [1]. The region in question has several  conserved NLS sequences [1]. The function of Red protein is unknown,  but efficient sequestration to nuclear bodies suggests that its  expression may be tightly regulated or that the protein self-aggregates extremely efficiently [1].	21.50	21.50	25.20	24.60	20.50	16.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.70	0.71	-3.91	7	152	2009-01-15 18:05:59	2004-08-18 17:18:46	6	11	110	0	95	143	0	113.50	59	20.48	CHANGED	YuECYPGh.E..cthsDSD-EsDaSKMDhGsK.KGsltRWDF-TpEEYucYMpsKEALPKAAFQaGVKMp-.GRKTR+.pt.+s-KtcLDR-hp+IspIlp++K.htcDGu..........sssK+sKa	.....................YAECYPuh...-.....D.hhsDSD-E...VDYS...KMD....G...N.......K..KGPLGRWDFDTpEEYS-YMssKEALPKAAFQ..................YGlKMu-.GR.K.T....R+....hp..E.......p.......N-KA.....ELDRpW+KIssIlpKRK..h-t.D..Gs..................p.K..........................	0	30	44	71
+7639	PF07808	RED_N		RED-like protein N-terminal region	Fenech M	anon	Pfam-B_9780 (release 14.0)	Family	This family contains sequences that are similar to the N-terminal region of Red protein (Swiss:Q13123). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements [1]. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region [1], suggesting that these proteins are expressed in the nucleus [1]. The function of Red protein is unknown, but efficient sequestration to nuclear bodies suggests that its expression may be tightly regulated of that the protein self-aggregates extremely efficiently [1].	20.40	20.40	20.40	21.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.67	0.70	-5.15	8	299	2009-09-10 21:25:46	2004-08-18 17:21:04	8	16	226	0	212	283	4	188.50	30	37.54	CHANGED	KKK+h.stLh+p-csc.cclspKYRDRA+ERRcGtNcDhcsssl.......ssa+AVssshtss.puu-pc+psIpESKFLGGDhEHTHLVKGLDauLLpKVRuElhsKpspE-E.......tsclststpt.h.tttp..ttcpt........p.pschpFpsplu+sI.............F+hh..hcp..............ppl.p.NEhFts.....GRMsYlh-L-sEh.-sDIPTTllRSKsDlPstctth.TlssNshlls+LuplhS.....ahRtuspspcsKKKcK	....................................................t..c.p..chsp..pYRDRA..+ERRcs.s....pDhp.p.sch.................tsh+Alt...s..h...p...h...s.....p.....s.t-.pc+.p.hIpc.SK.a..LGGDh-HTHL..VKGLDauLL..pKVR.......s....-........l.t....s.cppcc-c........................................................p.t..........................................p.pp..thtt...tp.l.............ht.....................................t.................h.................................................................................................................................................................................................................................................................................................................	0	74	115	170
+7640	PF07809	RTP801_C		RTP801 C-terminal region	Fenech M	anon	Pfam-B_5179 (release 14.0)	Family	The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene [1]. Two members of this family expressed by Drosophila melanogaster, Scylla (Swiss:Q9NHN4) and Charybde (Swiss:Q9NHN5), are designated by the GenBank as Hox targets [1].  RTP801 is thought to be involved in various cellular processes [1].  Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells [1]. Moreover, the protein product of the mouse homolog of RTP801 (dig2 (Swiss:Q9D3F7)) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment [2].	20.50	20.50	23.70	26.70	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.35	0.71	-4.43	9	137	2009-01-15 18:05:59	2004-08-19 09:24:11	6	1	74	2	82	122	0	115.20	45	52.81	CHANGED	LppAKpppLtCoclLlPscLhsplupEll+lStpEPCGlRGshl.lphEs-..pss+plAplpsDPssVsTFELhLsL+.Dpc.sWsplhsh...........Fhs.....s.uhspolpl...SssF+llKpKLYS	..............LppAK.ps..pLtCoclLlPpcLspclAp-lLRLupsEPCGLRGsllclslEpp......p.sC+cl..up.......lss.....D...P.............slVPTF..ELoLVL+.Dsp.sWsplpsh...........Fhs.......s.uhppolhL...SsuFRllKKKLYS................	0	14	19	48
+7641	PF07810	TMC		TMC domain	Fenech M	anon	Pfam-B_5063 (release 14.0)	Domain	These sequences are similar to a region conserved amongst various protein products of the transmembrane channel-like (TMC) gene family, such as Transmembrane channel-like protein 3 (Swiss:Q7TN63) and EVIN2 (Swiss:Q8IU68) - this region is termed the TMC domain [1].  Mutations in these genes are implicated in a number of human conditions, such as deafness and epidermodysplasia verruciformis [1]. TMC proteins are thought to have important cellular roles, and may be modifiers of ion channels or transporters [2].	25.00	25.00	25.40	28.80	20.80	23.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.30	0.72	-3.64	26	598	2012-10-02 00:51:22	2004-08-19 09:39:48	8	5	96	0	316	501	1	108.80	41	14.30	CHANGED	CWEThVGQEhY+LllhDFlhollsslhs-F.R+lhschh........hhhphhuhtEFsIspNVLcLlYuQTlsWhGsaFuPLLPslsslKLhllFYlKKhoLhtsspPsp+saRAS	.......................................................CWEThVGQ.Ehh+LhlhDhlhol.hs.hLls-FhR.tlhl.chh.........sh.hph...uhsEFcIucNVLpLl....YsQshhWhGsFFuPhLPs...lssl+Lhlhh.Yl+ph..ulhpsshP..tp+sFRAS..............	0	69	95	195
+7642	PF07811	TadE		TadE-like protein	Fenech M	anon	Pfam-B_9054 (release 14.0)	Family	The members of this family are similar to a region of  the protein product of the bacterial tadE locus (Swiss:Q9S4A6). In various bacterial species, the tad locus is closely  linked to flp-like genes, which encode proteins required  for the production of pili involved in adherence to  surfaces [1]. It is thought that the tad loci encode  proteins that act to assemble or export an Flp pilus in  various bacteria [1]. All tad loci but TadA have putative transmembrane regions [1], and in fact the region in  question is this family has a high proportion of hydrophobic  amino acid residues.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.76	0.72	-4.07	180	2004	2012-10-01 21:13:59	2004-08-19 09:47:00	7	12	920	0	798	1915	145	42.30	26	24.50	CHANGED	GssslEaul.lhPlhl.hllh...uhlchuhhhhspptlppAsppu...AR	.......GssslEFul.lhPlll.hllh....ullphuhhhhs....ppslspAuppuAR...................	0	265	502	654
+7643	PF07812	TfuA		TfuA-like protein	Fenech M	anon	Pfam-B_9826 (release 14.0)	Family	This family consists of a group of sequences that are similar to a region of TfuA protein (Swiss:Q52872). This protein is involved in the production of trifolitoxin (TFX), an gene-encoded, post-translationally modified peptide antibiotic [1]. The role of TfuA in TFX synthesis is unknown, and it may be involved in other cellular processes [1].	25.00	25.00	25.30	38.70	21.70	19.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.56	0.71	-4.66	32	184	2009-01-15 18:05:59	2004-08-19 09:53:57	7	2	149	0	90	162	10	118.40	46	33.95	CHANGED	DGlFtpssuVtH+EILtAlppGltVhGuuSMGALRAAELssaGMhGlGpIachY+cGtl......tsDDEVAlhasssph..tsLo.PLVNlRtTLptAhpssllsppttppLlssAcslaascRT	......DGhFhppsuVhHKElLt.AlspGVpVhGuuSMGALRAAELcsFGMhGlGtlFctYRcGhl.............psDDEVAVsHuss-.G..a.slopsLVNlRtTLptAhtsGllsspttcpllpsA+uhaaspRT..............................	0	24	50	66
+7644	PF07813	LTXXQ		LTXXQ motif family protein	Bateman A, Fenech M	anon	Pfam-B_6101 (release 14.0)	Family	This protein family includes two copies of a five residue motif is found in a number of bacterial proteins bearing similarity to the protein CpxP (Swiss:P32158). This is a periplasmic protein that aids in combating extracytoplasmic protein-mediated toxicity, and may also be involved in the response to alkaline pH [1]. Another member of this family, Spy (Swiss:P77754) is also a periplasmic protein that may be involved in the response to stress [2]. The homology between CpxP and Spy may indicate that these two proteins are functionally related [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.52	0.72	-3.55	46	1977	2012-10-02 12:34:46	2004-08-19 10:47:52	7	6	1152	10	392	1261	72	99.30	31	59.45	CHANGED	thttthstlhppLpLT-pQcsphpsltpshcsptpsh..........ppphtshtt................stssspclt..pphhstphct....hpthtpshpphhshLosEQ+pphcplt	...................th....tpshhacsL..sL..T-pQ+....pQh+-lh....pp....tR....cphpts...............shp-.h.c.sh+chh.....................sucsFDc..sts....cs..p..h.......p....c.....ht.ppptsp.....tl.t.hhcspsphYplLTPEQ+pphstp.h...................	0	95	201	302
+7645	PF07814	WAPL		Wings apart-like protein regulation of heterochromatin	Fenech M	anon	Pfam-B_9039 (release 14.0)	Family	This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure [1]. hWAPL (Swiss:Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [2]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [2].	23.90	23.90	24.00	24.00	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.97	0.70	-5.73	13	255	2009-09-14 15:20:58	2004-08-19 10:52:24	8	8	180	0	167	258	0	313.30	27	34.01	CHANGED	spsVKshpElpEhGEppEacD-lEYlLsuLc.sssshusRCLShlsLsoKChssuFRhplRA+Gh.sp+lh+sltDspcc...........................shuLssuslhalLopDthshch..DppslclhlpLLc.............................tsspcps...t.spptls+spptlhchscphc..s.....sp+hclcslosutLAhEoh.........hShosp+sGt.FK-cLR.LGuL-+llchlt-sht.........spst..ctpss.hpplhtlp+CL+lLEssolhsspNQsallpappuhhspptsphhpphptphhph...............................hhshl+lllNLTpsssp...chuosthspp.shlsssh.phhphsshlspcssa-hplLuLulLINLsEpSppsR	.....................................................................................................................l+php-lhchGEppcapD-l-alls..sl...p..s..s....p....sh.sh.RphS.hlpLssKhh..spF+hph.......Rup.Gh.s....tplhcsltstt.pc...........................shulss.u.sl....hhlLspst....shcl........cps..s...l...clhlpLLc......................................pt.....spstc............pppphsK...h.p.pt...l.hphs.cpl.p......................sp.......ph.c.l.p.shohuhLshEsl.................hsho.ppsst.h.+pplh.hGhL-pl....lchlhp..t...................p.s....tt.ptthhtshh.hhtp.sL.pl...LE..s.....sT..h...hs.....p...NQtal...ls..h..p.p...s...hh.....t.s..h.hhpt..stt...h.ph..............................................................................................................................................................................................................................hhhhltlllNlTpss.....p.hu.sp.t.h........spt...t.hl..s.sh....hhh..p..s..t.h..s..p..p...ph......h-hhlLhLshhlNhs..s.....................................................................................................................................................................................................................................................................................................................................	0	48	80	126
+7646	PF07815	Abi_HHR		Abl-interactor HHR	Fenech M	anon	Pfam-B_9732 (release 14.0)	Family	The region featured in this family is found towards the N-terminus of a number of adaptor proteins that interact  with Abl-family tyrosine kinases [1]. More specifically,  it is termed the homeo-domain homologous region (HHR), as it  is similar to the DNA-binding region of homeo-domain  proteins [2]. Other homeo-domain proteins have been  implicated in specifying positional information during embryonic development, and in the regulation of the expression of  cell-type specific genes [2]. The Abl-interactor proteins are thought to coordinate the cytoplasmic and nuclear functions of the Abl-family kinases, and seem to be involved  in cytoskeletal reorganisation, but their precise role remains  unclear [1].	19.60	19.60	20.00	19.70	18.40	18.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.80	0.72	-3.87	11	332	2009-01-15 18:05:59	2004-08-20 13:21:50	9	4	91	1	135	371	0	76.80	62	17.42	CHANGED	IuQsV-lHKEKVARREIGsLTssKpssRspKIluPus.....E.hh+YpRpPIsaosLDslGHGl+.st.....sspttp.pGol	...................ISQTVDIHKEKVARREIGILTTNKN.TSRTH.KIIAPAN....hERPVRYIRKPIDYTlLDDlGH..GVKh.h..p.tt................h...................	2	27	40	81
+7647	PF07816	DUF1645		Protein of unknown function (DUF1645)	Fenech M	anon	Pfam-B_8798 (release 14.0)	Family	These sequences are derived from a number of hypothetical plant proteins. The region in question is approximately 270 amino acids long. Some members of this family are annotated as yeast pheromone receptor proteins AR781 but no literature was found to support this.	21.60	21.60	21.60	21.60	21.00	21.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.90	0.71	-3.84	19	218	2009-01-15 18:05:59	2004-08-20 13:23:27	6	2	22	0	123	199	0	182.70	20	62.30	CHANGED	ADELFpsGpIRPlp............Plhsh...............................................................Rut.hphtspss.t.s......hRcshRsLSP.cst.................s.stpssppsp.pussPsshs.................sosssuss...pSsSsuuS++WR.L+DLl..LhRSpS-G+cs..........u+cshhphs..st.....................p.hh.su.cspts..................tsossts+pcspt.soAH-hhYssp.R.A....tuE-h+RR....TaLP	.....................................................................................................ADElFtsGpI+Phh.......................Phht......................................................................ptt.hp.tsts.....................h+t.h.+ph....ctt........................................................tttpssttsp.psssst..s.hs............................ssssspsp.....pS.sSstu..s...++W+..lpDhh...lh.RS.pS-G+pp..................s.p.....t.....................................................t..t.t.t.......................t..tttp....huscc..h..Y..t.t..t......ttt.t++....ohhP...........................................................................................................................................	0	10	65	99
+7648	PF07817	GLE1		GLE1-like protein	Fenech M, Wood V, Finn RD	anon	Pfam-B_9182 (release 14.0)	Family	The members of this family are sequences that are similar to the human protein GLE1 (Swiss:O75458). This protein is localised at the nuclear pore complexes and functions in poly(A)+ RNA export to the cytoplasm [1,2].	20.30	20.30	20.40	21.20	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.57	0.70	-5.45	22	279	2009-01-15 18:05:59	2004-08-20 13:27:05	8	5	230	4	208	288	4	240.30	25	41.92	CHANGED	htspIpph+pslht.lp.pcsplKchhspt+RpINsphGQlosop.ppltclhpclhph..........lstsps.s.L....uhpallshlAKtlVpQAEoE.lts+s..puAhPlAtlsh.hlhppaP-ht-hLhA+hhKKCPall....uaspuh..ssE-h+pphGa+cs.sss.hEcpssY.cRhuGhhpLaAAlsphph.tsphs.............................saulppu..W+aLARhlNh.st..........sssphsllusah-sAutphhptYupQhhKlLplltpc	................................................................................................thh.th...hp..ps.phKp.hhhphp+ths......h.l..uQl.....o....s.....s....pplpchhpc.ltph............................................t....hp...shs....pst.....................shta...hh.hhA...cthlpQs-sE..lssp......puAhPluh.lss...t.....lhp......t......h......P......c....h..t.......-llhA..+hh.+pCPahl.....shpp..s........spE..ch...........pc.hlG..........a........p....hp......s..........s...........t..hEpppsah...cRMsGhhplYAAlh.phphshsptp..............................pPaslspu..WpaLApllNh.Ph...........ssspsslLhshLcssutthhptY..tt.QhhKhl.hl...t.........................................................	0	69	110	165
+7649	PF07818	HCNGP		HCNGP-like protein	Fenech M	anon	Pfam-B_9462 (release 14.0)	Family	This family comprises sequences bearing significant  similarity to the mouse transcriptional regulator  protein HCNGP (Swiss:Q02614). This protein is localised to the nucleus and is thought to be involved in the  regulation of beta-2-microglobulin genes.	21.30	21.30	21.40	21.50	20.50	19.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.08	0.72	-3.95	22	256	2009-01-15 18:05:59	2004-08-20 13:28:23	8	6	213	0	187	254	3	94.20	34	31.46	CHANGED	IPPpPs.ucssstLppKlp+hhclKc..puhchNppltssppa+NPulhcKlhcahsID-...huTsaPt-lasPps.asp.sYh...-tLscsQ+ch..tchpp..K	...............................................lPPpPs.Gp.ss......s......p...LppKlp+.hhphKp.......pG.hchNpplppp+paRNPulhcKLlpassI.DE..............hGTsaPt-.laDPp.......s...asppuYh...-tLtcsQ+tt.hc+h-pt.p............................	0	64	102	147
+7650	PF07819	PGAP1		PGAP1-like protein	Fenech M	anon	Pfam-B_9244 (release 14.0)	Family	The sequences found in this family are similar to PGAP1 (Swiss:Q765A7). This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is  conserved in a number of lipases. PGAP1 functions as a  GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.42	0.70	-4.76	20	1253	2012-10-03 11:45:05	2004-08-20 13:29:28	8	39	770	0	638	5035	1134	153.30	17	24.56	CHANGED	clsGlPVLFIPG...NAGSa+..........QlRSlAuss..............pcs..ptsshp..............................................................hDaFolDFsE-hoAhaGpolh.-Qs-YlscAI+hILshY............tss.tsPpSVlllGHSMGGlVARshlshssahs....sslsoIlTLu.oPHstsPlshDsslhchYpplsphWpp.................tht.t.t...........LpslsllS.....lsGGhpD....hhlsu-aoslcs....hls.osuhpshoouIspVW.......hshDHhAllWCpQLhhtlu+sLhph	..................................................................................................................................................................t......................................................................................................................................................................................................................................................................................................................................................................................................h...t.......h......h.........p...t.....l...h.p.hh............................................................ts.pp....l..h...lluHSM.G.G..l..l.............u...+....t.h....l......h........h.......s.......t.t.......................p.....l.....p.....t....l...l...s.......lu..........o..P.....H.t...u....s......s......h..............................................................................................................................................................................................................................................................................................................................h................................................................................................................................................	0	197	363	534
+7651	PF07820	TraC		TraC-like protein	Fenech M	anon	Pfam-B_9690 (release 14.0)	Family	The members of this family are sequences that are similar to TraC (Swiss:Q84HT8). The gene encoding this protein is one of a group of genes found on plasmid p42a of Rhizobium etli CFN42 that are thought to be involved in the process of plasmid self-transmission. Mobilisation of plasmid p42a is of importance as it is required for transfer of plasmid p42a, which is also known as plasmid pSym as it carries most of the genes required for nodulation and nitrogen fixation by the symbiotic bacterium. The predicted protein products of p42a are similar to known transfer proteins of Agrobacterium tumefaciens plasmid pTiC58 [1].	20.80	20.80	20.90	23.30	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.90	0.72	-3.79	15	82	2009-01-15 18:05:59	2004-08-20 13:31:27	7	1	62	0	22	74	1	82.60	40	94.92	CHANGED	KKPouKIR-EIAKLQEQLKpAETREAERIGRlALKAGLGEIEI-EuELQuAFEElApRFRuGctsssG.........uuusuopssussuoGAuAGusuEA	...............Kps.tclcsEIt+Lp-pL+ph-s+pAERIGRlAlKuGLu-lEIs-sclpttFE-lAtRFRpGtttt.t.................................t...............................	0	1	8	14
+7652	PF07821	Alpha-amyl_C2		Alpha-amylase C-terminal beta-sheet domain	Fenech M	anon	Pfam-B_1278 (release 14.0)	Domain	This domain is organised as a five-stranded  anti-parallel beta-sheet [1,2]. It is the  probable result of a decay of the common-fold.	20.10	20.10	20.40	22.40	19.60	17.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.81	0.72	-4.10	33	290	2009-01-15 18:05:59	2004-08-23 10:31:22	7	8	64	15	116	300	10	61.20	48	13.67	CHANGED	pRsuIpsp.SslcIltA-uDLYsAhIDs..................KlhhKIGsc.....shhP....s...saplsssGp-YAVWEK	........pRsGIpup.Ssl+IL..tA-...uDhYlApI.Ds..................KVlsKIGs+hD.hssllP....s.......sa.p.hus.pGpDYAVWEK.............	0	30	72	97
+7653	PF07822	Toxin_13		Neurotoxin B-IV-like protein	Fenech M	anon	Pfam-B_66513 (release 14.0)	Domain	The members of this family resemble neurotoxin B-IV (Swiss:P01525), which is a crustacean-selective neurotoxin produced by the marine worm Cerebratulus lacteus. This highly cationic peptide is approximately 55 residues and is arranged to form two antiparallel helices connected by a well-defined loop in a hairpin structure. The branches of the hairpin are linked by four disulphide bonds. Three residues identified as being important for activity, namely Arg-17, -25 and -34, are found on the same face of the molecule, while another residue important for activity, Trp30, is on the opposite side. The protein's mode of action is not entirely understood, but it may act on voltage-gated sodium channels, possibly by binding to an as yet uncharacterised site on these proteins. Its site of interaction may also be less specific, for example it may interact with negatively charged membrane lipids [1].	20.90	20.90	26.70	129.30	18.10	16.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.17	0.72	-4.05	2	2	2009-01-15 18:05:59	2004-08-23 10:33:18	6	1	1	1	0	4	0	55.00	75	100.00	CHANGED	ASuTWGuuYPACENNCRKpYD.CI+CQGKWAGKRGKCAAHChlQpssCpsKCKKc	ASuTWGuuYPACENNCRKpYD.CI+CQGKWAGKRGKCAAHChlQpssCpsKCKKc	0	0	0	0
+7654	PF07823	CPDase		Cyclic phosphodiesterase-like protein	Fenech M	anon	Pfam-B_73368 (release 14.0)	Domain	Cyclic phosphodiesterase (CPDase, Swiss:O04147) is involved in the tRNA splicing pathway. This protein exhibits a bilobal arrangement of two alpha-beta modules. Two antiparallel helices are found on the outer side of each lobe and frame an antiparallel beta-sheet that is wrapped around an accessible cleft.  Moreover, the beta-strands of each lobe interact with the other lobe. The central water-filled cavity houses the enzyme's active site [1].	20.40	20.40	21.00	20.40	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.50	0.71	-4.82	15	138	2012-10-03 21:31:48	2004-08-23 10:36:00	6	4	118	6	92	200	152	191.60	23	91.61	CHANGED	M.......................hu..........lWhhPst..s.h.phppLl.puLpslFs......sp..........PsFEPHlTlsuslslc......sps-lpclLpu.ussulcul..t..................hlplssVssGcpYFc+lalplptsstLhulAplh+phFs...st.t................................................t.spaspptatPHlSLlYuDlp.h-p..sphptltpclccsh...............................suhuWs...hspltLVpC-Gs...Vc-WpllushsL	......................................................................hulWhhPst..shh.....pplptlh..tslpshas.....s.................PhFpPHlTlsu..s.lphp.......pts..ss..p..ph..Lpu..sssu.hpsh............................hlphsslss...u.c.p.a..a..pplalt.lp.s..t.lh...shsphh+phh................................................................tthspptahPHlSLl.Yu..Dl...cp....t.htth..tp.p..lpst......................................t.hsap....sphtlh...s...ps......lppWphltth.h...............................................................................	0	35	63	83
+7655	PF07824	Chaperone_III		Type III secretion chaperone domain	Fenech M	anon	Pfam-B_32938 (release 14.0)	Domain	Type III secretion chaperones are involved in delivering virulence effector proteins from  bacterial pathogens directly into eukaryotic cells. The chaperones may prevent aggregation and degradation of their substrates, may target the effector to the  secretion apparatus, and may ensure a secretion-component unfolded confirmation of their specific substrate. One member of this family, SigE (Swiss:O30917) forms  homodimers in crystal. The monomers have a novel fold  with an alpha-beta(3)-alpha-beta(2)-alpha topology [1].	25.00	25.00	25.40	38.40	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.45	0.71	-4.16	4	132	2012-10-01 22:01:34	2004-08-23 10:39:55	7	2	125	2	3	37	0	106.40	88	98.71	CHANGED	csll.pLYcALGL-.hshD-PAllIDDDlpIYFsEut-uLEMsCPhhsLP-slppLQphLpLNYASsVsLAsDA-sosLlALhRLPtpSstEEhhsGhphaIopV+pL+pchA	.......ESLLNRLYDALGLD.APEDEPLLIIDDGIQVYFNESDHTLEMCCPFMPLPDDILTLQHFLRLNYTSAVTI....GA...DADNTALVALYRLPQTSTEEEALTGFELFISNVKQLKEHYA..................	0	0	1	2
+7656	PF07825	Exc		Excisionase-like protein	Fenech M	anon	Pfam-B_46296 (release 14.0)	Domain	The phage-encoded excisionase protein (Xis, Swiss:P03699) is involved in excisive recombination by regulating the assembly of the excisive intasome and by inhibiting viral integration. It adopts an unusual 'winged'-helix structure in which two alpha helices are packed against two extended strands.  Also present in the structure is a two-stranded anti-parallel beta-sheet, whose strands are connected by a four-residue 'wing'.  During interaction with DNA, helix alpha2 is thought to insert into the major groove, while the wing contacts the adjacent minor groove or phosphodiester backbone. The C-terminal region of Xis is involved in interaction with phage-encoded integrase (Int), and a putative C-terminal alpha helix may fold upon interaction with Int and/or DNA [1].	21.40	21.40	21.40	21.60	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.62	0.72	-4.21	2	289	2012-10-04 14:01:12	2004-08-23 10:57:07	6	2	219	9	20	95	3	71.50	39	84.80	CHANGED	hhlTLpEWstcp.RpP.S.pTlRRWsREshIhPsPVKcGRpYhhctsAshh-.p.....PVsusLlpRItsu+hutp	.......hl..lTLpEW.ss..ccF.u.t.P..o.sTLpKYu+tGhIhP.P.KlGRcWhlDcpAhFV.G...s.s.......................................................pssh.........................	0	2	10	13
+7657	PF07826	IMP_cyclohyd		IMP cyclohydrolase-like protein	Fenech M	anon	Pfam-B_50235 (release 14.0)	Domain	This enzyme (Swiss:O27099) is may catalyse the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to inosine monophosphate (IMP), a reaction which is important in de novo purine biosynthesis in archaeal species. This single domain protein is arranged to form an overall fold that consists of a four-layered alpha-beta-beta-alpha core structure. The two antiparallel beta-sheets pack against each other and are covered by alpha-helices on one face of the molecule. The protein is structurally similar to members of the N-terminal nucleophile (NTN) hydrolase superfamily.  A deep pocket was in fact found on the surface of IMP cyclohydrolase in a position equivalent to that of active sites of NTN-hydrolases, but an N-terminal nucleophile could not be found. Therefore, it is thought that this enzyme is structurally but not functionally similar to members of the NTN-hydrolase family [1].	25.00	25.00	27.50	37.40	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.33	0.71	-4.97	6	187	2009-01-15 18:05:59	2004-08-23 11:01:02	6	2	187	13	63	183	27	212.30	40	92.54	CHANGED	MYlGRFLllG+sppG.shssYRVSSRSFPNRpshphs-ssssllPcDspE..hhcNPYIoYNClRlVs-ssVVoNGSHTDsIA-KlchGhs.RDALs.uLhsMDYEKD-YN.TPRIAullst-c.ualGhVss-cl..........hh+hsElcsGcuahLosYpt...ststhhshcucos.....E-sschsh...phtsFEHsVsuAsshhcs.........-GaclA.spsh	......................YPGRGIllG+o.t-G.pslsAYaI.......MGRS....sSRN.R.l..h.l..c-.......s..p...s.h.s..p..sh..Dsuc..lpDss.LIIYsPVRll.......G....s..psIVTNGDQTDTIhE....GhstptoFppuLpoR-aEPDuPNaTPRISGll...........c....h-s......s.h...hSIl.Ks.ssss.t..............s.RhtatapsshsGEGaaIpTYpp......Dus.PL....PSF-GEPt.h.......s-hsphs.....ps..Ls.-N+VSLh.s+hIDh.........tth.......thst......................................	0	22	44	57
+7658	PF07827	KNTase_C		KNTase C-terminal domain	Fenech M	anon	Pfam-B_29524 (release 14.0)	Domain	Kanamycin nucleotidyltransferase (KNTase) is involved  in conferring resistance to aminoglycoside antibiotics  and catalyses the transfer of a nucleoside monophosphate  group from a nucleotide to kanamycin. This enzyme is dimeric with each subunit being composed of two domains.  The C-terminal domain contains five alpha helices, four of which are organised into an up-and-down alpha helical  bundle. Residues found in this domain may contribute to this enzyme's active site [1].	26.40	26.40	26.50	27.00	22.90	26.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.80	0.71	-4.44	2	78	2012-10-01 22:14:54	2004-08-23 11:06:00	6	2	70	2	9	39	0	137.40	69	57.06	CHANGED	DstGahp+lh.sAcSsptpsF+pAIptllVtEhaEYsGKhRNlphpGPoTaLPSLslphAhhGAMLIGLHpphhaoTuA.VLsEAlK.schPpGaDHlsphsMSGpLupstKllpuhEsFWpGl.tWstcHsYllc.SKRIPF	................DSGGYLEKVYQTAKSVEAQTFHDAICALIVEELFEYAGKWRNIRVQGPTTFLP.SLTVQVAMAGAMLIGLHHRICYTTSASVLTEAVKQSDLPSGYD.HLCQFVMSGQLSDSEKLLESLENFWNGIQEWTERHGYIVDVSKRIPF..........	0	3	7	8
+7659	PF07828	PA-IL		PA-IL-like protein	Fenech M	anon	Pfam-B_99281 (release 14.0)	Family	The members of this family are similar to the galactophilic  lectin-1 expressed by P. aeruginosa ((PA-IL, Swiss:Q05097).  Lectins recognising specific carbohydrates found on the  surface of host cells are known to be involved in the  initiation of infections by this organism. The protein is thought to be organised into an extensive network of beta-sheets, as is the case with many other lectins [1].	20.80	20.80	21.60	46.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.63	0.71	-4.32	2	27	2012-10-03 19:46:52	2004-08-23 11:09:01	7	2	21	15	9	19	1	113.30	56	91.42	CHANGED	sWpGpV.ANsEsGpsTulIhp.GDsIolVAtGWspYG.sph.hstsDt.hPsp...spsu.husLVhKIuNpthh.sNssLa+hVs...VpGtlhLlaNDVPGTaGsNSGpFpVplhh-pp	.sWpGpV.ANsEsGQsTulIhpsGDVIoIVAuGWspYG..sppahstsptchP.....cphhhspsshssuLlhKIGNpuhh.sNsGLa+hVs...VpGtloLlaND..VPGoYGNNSGuFSVNlth-pp....	0	1	2	7
+7660	PF07829	Toxin_14		Alpha-A conotoxin PIVA-like protein	Fenech M	anon	Pfam-B_46690 (release 14.0)	Domain	Alpha-A conotoxin PIVA (Swiss:P55963) is the major paralytic  toxin found in the venom produced by the piscivorous snail  Conus purpurascens. This peptide acts by blocking the  acetylcholine binding site of the nicotinic acetylcholine receptor at the neuromuscular junction [1]. The overall shape of the peptide is described as an "iron" with a highly charged  hydrophilic loop of 15S-19R forming the "handle" domain that  is exposed to the exterior of the protein. The stability of  the conotoxin is primarily governed by three disulphide bonds. A triangular structural motif formed by residues 19R, 12H and  6Y is thought to constitute a "binding core" that is important in binding to the acetylcholine receptor [2].	25.00	25.00	30.70	57.60	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.29	0.72	-4.21	2	4	2009-01-15 18:05:59	2004-08-23 11:14:11	6	1	2	2	0	6	0	25.50	81	66.67	CHANGED	GCCGpYPNAACHPCuCp.sRPsYCsp	GCCGsYPNAACHPCuCK.sRPsYCsp	0	0	0	0
+7661	PF07830	PP2C_C		Protein serine/threonine phosphatase 2C, C-terminal domain	Fenech M	anon	Pfam-B_5253 (release 14.0)	Domain	Protein phosphatase 2C (PP2C) is involved in regulating  cellular responses to stress in various eukaryotes. It  consists of two domains: an N-terminal catalytic domain  and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices,  one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not  seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain [1].	22.70	22.70	22.80	23.90	20.80	22.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.72	0.72	-3.87	15	272	2009-01-15 18:05:59	2004-08-23 11:23:01	8	3	85	8	121	231	0	75.90	49	20.16	CHANGED	SllLlCFPGAP+VSEEAl++EtcL-chLEs+VEEllcc.sucpphPDLhpVh+sLuuEs.IPsLPPGGGLsSK+slIpsVYp+	.....................SllLlCFPsAPKVStEAV++EsELDKhLEsRVc.El....hpc...tttcshP...DL..spVh+h.Lu..uEs.....IPsLPPGGGLsu.....K..+.slIEtsYpc............	0	26	37	69
+7662	PF07831	PYNP_C		Pyrimidine nucleoside phosphorylase C-terminal domain	Fenech M	anon	Pfam-B_1661 (release 14.0)	Domain	This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases [1,2]. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP, Swiss:P77826) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP, Swiss:P07650) [1]. The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer [1].	20.50	20.50	20.50	21.40	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.21	0.72	-4.52	54	2815	2012-10-02 20:27:15	2004-08-23 11:28:27	8	10	2677	20	573	1892	417	73.80	36	16.87	CHANGED	alsplsspplGhsuhtLGAGRtpppD.IDhusGlhlp+KlG-pVcpG-slhslauscct.hcpshstlppshtIu	.......................................hloplsupslGhAuhtLGAGRtptpD.sIDhuVGlhhpt+lGDpVc..pG.c.sLssl.ausccs....hp.pshptlppulpl...................	0	197	372	477
+7663	PF07832	Bse634I		Cfr10I/Bse634I restriction endonuclease	Fenech M	anon	Pfam-B_46671 (release 14.0)	Domain	Cfr10I (Swiss:P56200) and Bse634I (Swiss:Q8RT53) are two Type II restriction endonucleases. They exhibit a conserved  tetrameric architecture that is of functional importance, wherein two dimers are arranged 'back-to-back' with their  putative DNA-binding clefts facing opposite directions.  These clefts are formed between two monomers that interact, mainly via hydrophobic interactions supported by a few hydrogen bonds, to form a U-shaped dimer. Each monomer is folded to form a compact alpha-beta structure, whose core is made up of a five-stranded mixed beta-sheet.The monomer may be split into  separate N-terminal and C-terminal subdomains at a hinge located in helix alpha3 [1].	20.70	20.70	22.80	21.60	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.54	0.70	-5.28	4	13	2012-10-11 20:44:44	2004-08-23 11:38:48	6	2	11	37	2	16	0	267.20	23	86.22	CHANGED	hssIpthsEs..GKhplN.+..assluphl-Ntlsps.phpc.LDthRs.ssctActtG...ppsusuuhspssGsW.ElMlu.......ph.chhLp.s.pp.l...VlpMPNsp..........SFDahslacsEhpEhI.phcupL..pKssltL.TSsPDlulI......E-.Ks..c-hhpp.Ist.T+ss.sh..sLYpphps+sphcclpuululKTShRPDRRhQ.laEuslhKuL.salphphW........KYahssop.lusADssuhpT...sAsHulsps+Shsp+AVD-lahhsohtDlsphlsphlpc	............................................th..hp.t....sh.p.h...hs.t.ph.c....hpshhtt.scttt...th.ssuAhsNssGsW.Ehhhu.........ltshphhhp..ssp..p...l...llphPN.p..........oaDhhpLacsphpptlpsL....cppL.......ptsplpLhoSsPDllIl........pthps..pshhh....psIsphocs.shsh.....slYpphps+sch.cslhuhlulKTShRPDRRhQ.laEusllKuL..salppptW.................hKYYutuop.lusADspuhpT...sAsHolspspshPp+AVDclaphsohtDlsphlpphl..............	1	1	1	1
+7664	PF07833	Cu_amine_oxidN1		Copper amine oxidase N-terminal domain	Fenech M	anon	Pfam-B_46519 (release 14.0)	Domain	Copper amine oxidases catalyse the oxidative deamination  of primary amines to the corresponding aldehydes, while reducing molecular oxygen to hydrogen peroxide. These  enzymes are dimers of identical subunits, each comprising four domains. The N-terminal domain, which is absent in  some amine oxidases, consists of a five-stranded antiparallel beta sheet twisted around an alpha helix. The D1 domains from the two subunits comprise the 'stalk' of the mushroom-shaped dimer, and interact with each other but do not pack tightly against each other [1,2].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.42	0.72	-3.65	134	2772	2009-09-11 19:31:59	2004-08-23 13:46:59	6	269	442	32	1082	2618	19	86.20	21	23.12	CHANGED	tssRshVPlRhlu..-uL..G..s...pVpW.sspspslsl..pp......sspp.....lplp.l................G.....sptshl........N.......G.......pphthc..sss.h....lt...t....uR..ThVPlRaluEshG.hp...........VpW.-sp.....spslhl	...........................................................................................hhlPhc.h.........p.t.h.....s....h.......pl.ta....ptt...t...p.t....hhh...p.............................sst.t..........lp..hp.h.....................................................................s.......s.p.phh.l............................N..............G............p..p..h..phs......ssshl..........hs......uc..shVPl+.hl.u-.shG...hp...........lpa.stt...........................................................................................................................	0	649	941	984
+7665	PF07834	RanGAP1_C		RanGAP1 C-terminal domain	Fenech M	anon	Pfam-B_23411 (release 14.0)	Domain	Ran-GTPase activating protein 1 (RanGAP1, Swiss:P46061) is a GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Its C-terminal domain is required for RanGAP1 localisation at the vertebrate nuclear pore complex, and is sumoylated by the small ubiquitin-related modifier protein (SUMO-1, Swiss:Q93068). This domain is composed almost entirely of helical substructures that are organised into an alpha-alpha superhelix fold, with the exception of the peptide containing the lysine residue required for SUMO-1 conjugation [1].	25.00	25.00	27.10	26.40	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.89	0.71	-4.85	3	102	2009-01-15 18:05:59	2004-08-25 09:31:02	6	11	54	14	43	98	0	173.50	54	32.44	CHANGED	GsDuEssu+stpcPsluEsAPs.sPPhPuDlSTFLuFPSPEKLlRLGPKRSsLIAQQVDVoDsEKVVpAFLKVSSVYKDEuEVKtAVpETlDALM+KAFsNSuF.QSNoFITSLLVpMGLLKSED.KVKsIusLsGPLLTLNHMVQQ-YFPKuLAulLLAFVSKPNuVLESCuSARHoLLpTLaK	...........................tcstssppch.csss.uEss.Ps....hss...ss.PsDlSTFLuFPSPEKLLRL.GPK.sSh.L......I......sQQT..D.T.....SD..s.EK.......V....Vs........AFL........KVS...SVa..+.............D.-..u..s..V....+..oAVt-ulDALMKKAFSouoF..NSssFl..T.pLLlHMGLLKSED...Kl.K.A.I.s.sLaGPLM.sLNHh..VQQDYFPKuLAPlLlAFlTKPN....tALEoCSh.ARHsLLQTLap...................	0	10	13	26
+7666	PF07835	COX4_pro_2		Bacterial aa3 type cytochrome c oxidase subunit IV	Fenech M	anon	Pfam-B_86185 (release 14.0)	Domain	Bacterial cytochrome c oxidase is found bound to the  to the cell membrane, where it is involved in the  generation of the transmembrane proton electrochemical gradient. It is composed of four subunits. Subunit IV consists of one transmembrane helix that does not interact  directly with the other subunits, but maintains its position by indirect contacts via phospholipid molecules found in the structure. The function of subunit IV is as yet unknown [1].	20.30	20.30	20.40	20.60	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-7.95	0.72	-3.98	36	225	2009-01-15 18:05:59	2004-08-25 15:22:17	7	1	213	5	76	177	38	44.90	37	68.34	CHANGED	Hcc........utMDhstpE+TacuFl+hsphuslsllsl...LlhhAlhhs	..................Hpp......huusMDYspHE+TYsGFlthsKauolsllsl...llhMAhhhh.........	1	16	40	56
+7667	PF07836	DmpG_comm		DmpG-like communication domain	Fenech M	anon	Pfam-B_1675 (release 14.0)	Domain	This domain is found towards the C-terminal region  of various aldolase enzymes. It consists of five  alpha-helices, four of which form an antiparallel helical bundle that plugs the C-terminus of the N-terminal TIM barrel domain [1]. The communication domain is thought to play an important role in the  heterodimerisation of the enzyme [1].	21.00	21.00	21.10	24.10	19.50	20.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.97	0.72	-4.57	37	789	2009-01-15 18:05:59	2004-08-25 15:24:35	6	8	628	4	196	566	103	65.60	60	19.32	CHANGED	pssplDRpoLslGYAGVYSSFLhHAcRAAp+aGVDsR-ILlELGRR+hVGGQEDhIlDlAh-Lupp	............PlRVDR-oLsLGYAGVYSSFL+HsEpAAt+Y.GlsAhDILVELG+R+hVGGQEDMIlDlAL-Ltp.t..................	0	45	122	167
+7668	PF07837	FTCD_N		Formiminotransferase domain, N-terminal subdomain	Fenech M	anon	Pfam-B_4434 (release 14.0)	Domain	The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This,  in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a  short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to  form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [1].	19.20	19.20	19.80	23.20	18.10	16.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.86	0.71	-4.76	37	493	2009-01-15 18:05:59	2004-08-25 15:26:05	7	7	380	6	191	419	213	172.50	42	49.65	CHANGED	KlVECVPNFSEGRcp-hl-tIhsshp.shpGVpLLDhssDssHNRoVlThVG-P...........-slhcAshpus+hAs-LIDhppHcGp.HPRhGAsDVlPFlPlpssTMEEClplA+plGccluccLtlPVYLYpcuAspPcRcsLssIR+G..paEuht-Kl.KpscW...........cPDaGPsphp...PouGsTslGAR.	.......................pllEClPNFSEGR..spphI-...tIsps.....h......+......s.....h.....s.........G....V..pLL.DhssDtsaNRoVhT.l.V.Gc.P.......................cs.l..t-AshphschAschI....Dhsp.HpG.p........HPRhGAsDVlPFlPl.p..s.s..T..........h-EClplA+.p.....l.ucclu.c.c...l.s.lPVaLYEpuA..s.p.PcRcsLsslR+G..paEuh.tE..K..l....p.ps...c.W...................tP.Da..Gs.t...php...PosGsTslGAR.........................................	0	81	121	155
+7670	PF07839	CaM_binding		Plant calmodulin-binding domain	Fenech M	anon	Pfam-B_9279 (release 14.0)	Domain	The sequences featured in this family are found repeated  in a number of plant calmodulin-binding proteins (such as Swiss:Q8W235, Swiss:Q84ZT8 and Swiss:Q8H6X1), and are  thought to constitute the calmodulin-binding domains [1,2]. Binding of the proteins to calmodulin depends on the presence of calcium ions [1,2]. These proteins are thought to be  involved in various processes, such as plant defence responses [1] and stolonisation or tuberization [2].	21.00	21.00	22.40	21.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.55	0.71	-3.87	19	140	2009-01-15 18:05:59	2004-08-25 15:30:43	6	6	22	0	90	126	0	105.70	30	21.15	CHANGED	pppptp.ppsphhcspspppps+phpph+csll.hp+hs....pshccsh+hsshtsphls.ps-.s-sE+V.sLRH.Qcsp-..+Kcu-chMlDaAlccslSKLsssRKpKVchLVpAFETVls	....................................................................................h................t.tt.p...t....pp..hp...hcthh....tp......pt.cphtphp....t.....ph..hs.psp.....csEcV..LRH.Qpsp-..+Kpuc.hhhspslccssoKLs..sRK.pKVchLVtAFETVls...	0	12	52	72
+7671	PF07840	FadR_C		FadR C-terminal domain	Fenech M	anon	Pfam-B_11411 (release 14.0)	Family	This family contains sequences that are similar to the fatty acid metabolism regulator protein (FadR, Swiss:P09371). This functions as a dimer, with each monomer being composed of an N-terminal DNA-binding domain and a regulatory C-terminal domain. A linker comprising two short alpha helices joins the two domains. In the C-terminal domain, an antiparallel array of six alpha helices forms a barrel-like structure, while a seventh alpha helix forms a 'lid' at the end closest to the N-terminal domain. This structure was found to be similar to that of the C-terminal domain of the Tet repressor. Long-chain acyl-CoA thioesters interact directly and reversibly with the C-terminal domain, and this interaction affects the structure and therefore the DNA binding properties of the N-terminal domain [1].	23.00	23.00	23.20	23.30	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.88	0.71	-4.62	29	828	2012-10-01 22:11:53	2004-08-25 15:31:18	7	3	818	8	104	339	14	167.80	62	68.98	CHANGED	NNFWETSGLNILETLs+L.DtsthPpLl-sLLSARTNlSsIalRtAl+tNP-cs..............................hElLsphcpl--s..............AcAaspaDYpLa+pLAFsSGNPlYsLILNGhKGLYoRVGpaYFusscuRpLAhsFYcpLhplscpppa-plhthlRpYGhpSGtIWpph+ssl..Ppshs	...................................................NNFWETSGLNILETLARL.D.HESVPQLIDNLLSVRTNISo....I.FI.R.TA.hRpHP...-K.A...................................................................pEVLAsA..pE....V....sD+........................................A-AFA-LDYsIFRGLAFASGN.PIYGLILNGh..K.G.LYT.RIG.RaYFuN.PEARpLALsF....Y++LuuLCppG.s+DQVhEsVR+YG+-SG-IWH+MQcsLPuDL.A..........................................................	0	15	38	73
+7672	PF07841	DM4_12		DM4/DM12 family	Fenech M	anon	Pfam-B_5243 (release 14.0)	Family	This family contains sequences derived from hypothetical proteins expressed by two insect species, D. melanogaster and A. gambiae. The region in question is approximately 115 amino acid residues long and contains four highly- conserved cysteine residues.	21.70	21.70	21.80	21.90	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-10.08	0.72	-3.65	45	504	2009-01-15 18:05:59	2004-08-25 15:54:11	8	5	28	0	367	546	0	82.60	26	33.78	CHANGED	RpplYchlEphl.sphGh...sG..+sClLRsICEsuph.h...ctsGllu-ll+llFoPspscst.........pYhpActhGptt...s-Cppha..t.pC	..........................Rh.lYphlEphh.p...p.h..Gh.......sG+sClLRsICEs.u.phsh..........pp........pu.l.....l.u-.......ll..+llhosspsp.t................................tpYhpApphGptt..............tsCtphat.pC......................................................	0	91	117	287
+7673	PF07842	GCFC		GC-rich sequence DNA-binding factor-like protein	Fenech M, Mistry J, Wood V	anon	Pfam-B_9357 (release 14.0) & Pfam-B_9894 (release 19.0)	Family	Sequences found in this family are similar to a region of a human GC-rich sequence DNA-binding factor homolog (Swiss:Q9Y5B6). This is thought to be a protein involved in transcriptional regulation due to partial homologies  to a transcription repressor and histone-interacting protein  [1]. This family also contains tuftelin interacting protein 11 which has been identified as both a nuclear and cytoplasmic protein, and has been implicated in the secretory pathway.  Sip1, a septin interacting protein [2] is also a member of this family.	20.20	20.20	20.60	20.60	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.90	0.70	-5.04	36	631	2009-01-15 18:05:59	2004-08-25 15:56:45	7	15	282	0	392	539	6	222.60	22	31.13	CHANGED	LppltptFcphppca.pcYc...phtLuplAsuhltPLl+pthhsWsPLcsss...hlt.htph+.lL................................t..ssYcshlWpshlsthp.sshspWpst.sssshlsllptW.slLP.hhhpsll-plllP+Lp..ptVpp.WcPhocsh.....sh.p....sWlaPWLPhLs.p+hcs....................lhssI+pKlppsLpsWp.p.tush.hLp.W.pclass...........tpasshlhppllP+LtttLp...ph.lsP.pp..Qs..lchhptlhpWpsllssphhspL..l.ppFFsc...WhpsL	.................................................................................................................................................................pthhphFpphpppa.ppYp...ph.lu.hhst.hltPll+.plh....s.Ws.P...........L...............ppss.....................................................................psa.c.ph..hW..hhh.hh...t.t.....t.php.c.....ps..............ss..h...plls....................................s.ll-.p........lllP+Lp..thlcp..Wc............Pho.ss...............sh.p...........hlhshh..sh.h..t.....t.p.hcs....................lhpslht+h.ppsl........p.p.......................................slahs............................a.t....h..h.p.phhsthth.hhp...........tp.....ps.......h.chht.lhtW...p..shls...ph.............hhtl..h.t.phhs+...a......................................................................	2	116	174	305
+7674	PF07843	DUF1634		Protein of unknown function (DUF1634)	Fenech M	anon	Pfam-B_9594 (release 14.0)	Family	This family contains many hypothetical bacterial and archaeal proteins. A few members of this family are annotated as being putative transmembrane proteins, and the region in question in fact contains many  hydrophobic residues.	21.00	21.00	21.10	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.20	0.72	-4.40	45	351	2009-01-15 18:05:59	2004-08-25 16:01:49	6	4	335	0	99	238	4	98.50	34	79.49	CHANGED	IutlLRhGVlluusllhlGhllhhlpssu...............h...ts..hs.stlhpuhhthcuhslI..hhGLhlLIhTPlhRVllulhsFhpE+DhlYssIoh.....lVLhhLhhul...hl	..............................................................IuplL+hGVhluuhlIhhGllhhhlpsts...................t...ht..tlh.puhht......hpshsll..hhGlhlLIlTPVLRVslulhsF.hpE+DhhYVh.ITslVLhIlhhuhl...........	0	39	67	87
+7676	PF07845	DUF1636		Protein of unknown function (DUF1636)	Fenech M	anon	Pfam-B_9608 (release 14.0)	Family	The sequences featured in this family are derived from a number of hypothetical prokaryotic proteins. The region in question is approximately 130 amino acids long.	28.10	28.10	28.10	28.50	28.00	27.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.56	0.71	-3.85	52	189	2009-01-15 18:05:59	2004-08-25 16:05:15	6	1	150	0	66	191	92	110.70	33	83.77	CHANGED	lhVCsoC+tt.......tss.psGttLhstLpst..t.s..tt...lplpsVpCLsuCs+..uCsVAlp.uss+hoYlaGcl....sst...sssssllshAthYtsoscGhlPa+cRPptl+cphlARIPP	........................lhVCsoC+ts..........tss.ps...GttLhstLpst..........s......ts...lplcsVpCLuuCs+..sColAlp.usu+hoYlaGcl....ss......ssupsllshAphYtsos-GhlPapcRPpsl+cthlARlPP...............	0	12	42	48
+7677	PF07846	Metallothio_Cad	Metallothio_7;	Metallothionein family	Fenech M	anon	Pfam-B_9622 (release 14.0)	Family	The sequences making up Metallothio_Cad are found repeated in metallothionein proteins expressed by several different Tetrahymena species. Metallothioneins are low molecular mass, cysteine-rich metal-binding proteins that are thought to be involved in the regulation of levels of trace metals, and detoxification of these metals when present in excess [1]. Some of the metallothioneins found in this family (for example, Swiss:Q8T6B3) are known to be induced by cadmium and are thought to be involved in the cellular sequestration of toxic metal ions. The high proportion of cysteine residues allows the metal ions to be bound by the formation of clusters of metal-thiolate complexes [1]. Tetrahymena spp. metallothioneins differ from other eukaryotic metallothioneins mainly in the length of their sequences and in the cysteine-containing motifs they exhibit.	19.50	19.50	24.70	23.70	16.80	15.80	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.37	0.72	-4.02	4	42	2012-10-04 14:35:37	2004-08-25 16:06:25	6	4	9	0	0	48	0	20.80	83	35.79	CHANGED	CCCGsNAKPCCTDPNSGCCCV	CCCG-pAKsCCTDPNSGCCCs.	0	0	0	0
+7678	PF07847	DUF1637		Protein of unknown function (DUF1637)	Fenech M	anon	Pfam-B_6051 (release 14.0)	Family	This family contains many eukaryotic hypothetical proteins. The region featured in this family is approximately 120 residues long. According to InterPro annotation, some members of this family may belong to the cupin superfamily.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.52	0.71	-4.95	32	328	2012-10-10 13:59:34	2004-08-25 16:08:44	7	5	139	0	188	457	26	187.40	32	75.01	CHANGED	llcplpspDlslpsphth......................................stp...hssloYhcl.aEs-.sFShulFhLssuusIPLHDHPGMsVhpKlLaGpl+lcSaDhlc........s.ssstt.p............s+hAplh.sssp....hosssssslL...hPpp.........sNlHphsAls...PsAhLDlLuPPYs...sstG.RcCsYYcthshss...........t........................................hsaLpEh...s.Pcsah.hts..Y.GP.pl	...................................................................hsphpstDltlt.t....................................................t..sslsYhc..l..a..Es..c....sFS...hu.....lF.h.L.P.s..uu.sIPLHsHPuMsV......hoKlLa.Gsl+lcSYDhlc................s...s........tt......................................................h+hAplh.h-s..........housss.sslL...hPpp...............GNlHphsAls......ssAhLDlL.......uP..PYs...........t...tG....RcCsYYc.h..sp..........................................................t.shL.ch.....Ppshh.htt..Y.GP.................................................................................................	0	43	102	152
+7679	PF07848	PaaX		PaaX-like protein	Fenech M	anon	Pfam-B_9563 (release 14.0)	Family	This family contains proteins that are similar to the product  of the paaX gene of Escherichia coli (Swiss:P76086). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid [1].  In fact, some members of this family are annotated by InterPro as  containing a winged helix DNA-binding domain (Interpro:IPR009058).	22.70	22.70	22.70	22.80	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.04	0.72	-3.98	13	652	2012-10-04 14:01:12	2004-08-25 16:08:49	7	2	571	5	164	630	53	68.10	38	23.66	CHANGED	pApSlIlTLaGDhlts+GGslhlusLIpLhtshGlsEpslRsAloRhsppGhLssp+sGp.puhYpLS-+u	.................................upSLIholaGD..lt.t.+.G....u.p..lhluuLlt.Ll.p.s.h...G..hsEphVRoALhRLs+cGhL....ss.s...+hG..R.puhYpLo-p................	0	45	102	139
+7680	PF07849	DUF1641		Protein of unknown function (DUF1641)	Fenech M	anon	Pfam-B_9217 (release 14.0)	Family	Archaeal and bacterial hypothetical proteins are found in this family, with the region in question  being approximately 40 residues long.	20.30	20.30	20.40	20.70	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.29	0.72	-7.74	0.72	-4.34	60	843	2009-01-15 18:05:59	2004-08-25 16:10:27	6	1	521	0	181	438	10	40.50	33	23.65	CHANGED	shpshcssp......lulhsLl+tL+DPDlp+uLGhhlshLKslG+s	..................s..pphpsscc.....sulhuLl+.s.LKDPDhpRulsahlshLKuhup.........	0	52	107	147
+7681	PF07850	Renin_r		Renin receptor-like protein	Fenech M	anon	Pfam-B_9266 (release 14.0)	Family	The sequences featured in this family are similar to a region of the human renin receptor (Swiss:Q8NG15) that bears a putative transmembrane spanning segment [1].  The renin receptor is involved in intracellular signal  transduction by the activation of the ERK1/ERK2 pathway,  and it also serves to increase the efficiency of angiotensinogen  cleavage by receptor-bound renin, therefore facilitating  angiotensin II generation and action on a cell surface [1].	21.30	21.30	21.70	21.60	21.20	19.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.25	0.72	-3.65	8	137	2009-01-15 18:05:59	2004-08-25 16:10:47	9	4	93	4	83	131	0	95.90	43	27.64	CHANGED	shYGGsAVVEllT..scoh-ssLsRcsRsIlpocs..............hpssssPYNLAYpYsh-YuVIFNIlLWlhlsLuLAVIsISYslWsMDPGhDSIIYRMTsQ+I+hD	......................................................................t.hYsusslVphls....csh-ss.hhRpsRs..llp..scp...................................psss..sPYNLA.hp..Ysh-.Y...sVl..FNIlLWhMlsLuLullslsYslh.N.MDPGhDSIIYRMTsp+l+hD........	0	27	34	59
+7682	PF07851	TMPIT		TMPIT-like protein	Fenech M	anon	Pfam-B_9674 (release 14.0)	Family	A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.	22.90	22.90	25.40	23.50	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.09	0.70	-5.36	14	274	2009-01-15 18:05:59	2004-08-25 16:11:51	8	8	130	0	167	257	5	265.40	39	89.51	CHANGED	cshpEWp-Lpc-appLp-TH+hYppKLE-lspLQppCossIs+Q+++L+plppsL+phpts.......lss..E-hctlpclcppl+cRpstha-ME..uaLPcK.NGlYLsLlLG.sVNVoLLs+psKFtYKDEYEKFKLhlTlIhllhuhhCpalhsY.......RshDtlFsFLLVWYYCTLTIRESILhsNGSRIKGWWlhHHYlSThhuGVhLTW.....PpG.haQhFRsQFl.FshY.ShVQaLQahYQuGCLYRL+ALGERHpMDlTlE....GFpSWMWRGLoFLLPFLFhGahaQhYNuhTLFphuppspsp.EWQVhhhuhhFLlLFlGNhhTTLtVVhpKhppp...p	............................................................................tlpptt.p..ah.phpphtthpp.psttlpppph....p....h.pplt.slp..pht.................t.phhpplptp...hpctpshhh......-h-......shL.Pp+.sGh.aLplhLG..sVNVphhppps+htaK-................EYEpFKhhhsllhllhshhhhhlhph......................phhsthaphhLlaaYsTLslREsILhsNGS+I+uWWl.HHYlSshhusVhLTW.....P.s.s.ha.........QhFpppF...L......tauhhQ..uhVQhLQ.hYQpGpLYphhALGc.tpphDlo...p....G.pu.hhhtt.....Lh.hLhPh.LFhhph.aQhY....suht.Lh...........ph......u..............sp...pW.............Q.......V.h...huhhh...llhhhGNhhsTl.slhtKhp.p....t.......................................................	0	49	72	121
+7683	PF07852	DUF1642		Protein of unknown function (DUF1642)	Fenech M	anon	Pfam-B_9838 (release 14.0)	Family	The sequences making up this family are derived from various hypothetical phage and prophage proteins. The region in question is approximately 140 amino acids long.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.16	0.71	-3.83	54	426	2009-01-15 18:05:59	2004-08-25 16:12:14	6	4	292	0	26	304	0	123.50	24	69.65	CHANGED	pthshVP...phVA-aIEppK..tt.........hpshphh.h.tp.........................................chhpW...........ss.chhhpAals..G............YpVEK......EpLYhVcl.ps.....................h.hhppth..t...................hphTcpEI.cp.s..chtWtat......lcVc	...................................................................thshVP...phVA-Wl-ps+........pp.................phh.t.....h.pp.............sp.....................ch.pW.............h...hppshch.....hs.pAals..G...............YEVEK......Eph.YhVcl.t.t........................hh.h.tpph.......................hphTcpEl.cp.s..ph.W.at......h.l..................................................	0	9	16	20
+7684	PF07853	DUF1648		Protein of unknown function (DUF1648)	Fenech M	anon	Pfam-B_9801 (release 14.0)	Family	Members of this family are hypothetical proteins  expressed by either bacterial or archaeal species. Some of these are annotated as being transmembrane  proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues.	28.70	28.70	28.70	28.70	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.32	0.72	-4.45	86	1279	2009-01-15 18:05:59	2004-08-25 16:13:32	6	12	929	0	232	913	44	52.80	25	26.36	CHANGED	hllhlhshlhsh..hhaspLPcplssHashsGpsDsassKh.hshhhhPl.......lhlh	......................hlhlhhhhhsl....hhY...s....p.LPsp..lPhHash.sGp.sDsassKh..hslh.hhPh..hhh.h.....................	0	95	171	201
+7685	PF07854	DUF1646		Protein of unknown function (DUF1646)	Fenech M	anon	Pfam-B_9337 (release 14.0)	Family	Some of the members of this family are hypothetical bacterial and archaeal proteins, but others are annotated as being cation transporters expressed by the archaebacterium Methanosarcina mazei (Swiss:Q8PXG5, Swiss:Q8PXG7 and Swiss:Q8PXG8).	20.30	20.30	20.40	20.30	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.00	0.70	-5.32	6	83	2012-10-02 15:12:49	2004-08-25 16:13:47	7	2	52	0	45	108	23	323.20	43	93.85	CHANGED	lAuLlVILlLlLlLPFhl+hlEcNLEhFhhsM...GlAushlSGl.........aSh-LlhcAFcsPLtlhp..lh.IPlGIsQsVLlsGLlFaha+c+lhphltpsh-+lul+VFuFllIslLGLhSSlISAIlAulILsEllshhPLsRKsKlchsVIAsFuIGhGAALTPlGEPLSTIAlSKL.....NtcFhYLhclLGhYIIPulhshGlhusahlp+hsh+p.hlEh..V-YsEsl+-......VllRAhKVFVFIhALpLLGpGFKPlIhhYlsclsSclLYWlNhlSAllDNATLAAAEIuPphTpEQIRuhLMGLLISGGMLIPGNIPNIluAG+L+Is.pEWARlGlPLGlIhhllYFIllaVL	....................................................h..hLllIllllLlLPFhh+tlE+NLEhFLhlM...Glh...AshlSth.....................hshcLl.cshps.lhhh..........Is.sVLlu.GLlFhh.h+s+lpphl.pt.lhctl...s.lclhlFlllllLGLhSSlITAIlAullLVEl.l.phhPL.c.RpsKl.clsVluCFuIG.hGAALTPlGEPLSTIslSKL.....p.A...-......F....h.YL.hchlGhhI.ls.ullhhulluhhhl.t+..t....ph....ps........hpt..........hp.t.p......Esl+c.................VhlRAhKlalFlhALpLLGsGFKPlIctYllclsstlLYWlN.h.lSAlLDNATLA..AAEIoPt..Ms.tQl+AlLhGLLISGGM.LIPGNIPNIIuAuK.....Lp.IpS+EWA+lGlPlGllhhllYalllFh..........................................................	0	13	31	32
+7686	PF07855	DUF1649		Protein of unknown function (DUF1649)	Fenech M	anon	Pfam-B_9402 (release 14.0)	Family	This family is made up of sequences derived from hypothetical eukaryotic proteins of unknown function. 	20.50	20.50	24.00	20.70	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.95	0.71	-4.57	11	256	2009-01-15 18:05:59	2004-08-25 16:18:47	7	7	211	0	187	241	2	158.50	30	73.51	CHANGED	lElhs-sppV+DlVcuILHTIhFHR..............huoltPp..opDhlDhThstlsssEL-phl-p+lsshlcplcsspsp.................................spGQIulpFa-K++++.............sW.F..........hp.................................u-EpVsWE.WTlcVslspscoEt-+tpsRcuhpc..................pLpcslhcIlplsN+c.DaIPPIsTpsps	.....................-l.h-.pplc-slt.u...........lLHTIhFHR................h.us.ltsp..sp-hl.-hTas......t.s.ss.s-L-phlcpclsphhctl.c...pss.ss.............................................hpGQl...slpFap....K....++p+.................W..F...............................................................s-Epl...sWE.Wslplplh....p..........p..s........c...p....-.........+ths+cthtp............................tLpctlhpIlphhN.cc.....-alP.hsopt.........................................................................	0	63	101	154
+7687	PF07856	Orai-1	DUF1650; Orai-1_Ce; 	Mediator of CRAC channel activity	Fenech M, Pollington JE	anon	Pfam-B_9685 (release 14.0)	Family	ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [1].	25.00	25.00	33.60	28.70	21.60	20.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.29	0.71	-4.70	15	268	2009-10-24 14:23:42	2004-08-25 16:20:09	7	6	107	0	171	238	1	183.50	52	64.56	CHANGED	p+aplpslppR+L-.uR..................tQLKAoSppSALLuGFAMVAhVElQhscspph....spuLLlAFussTollVuVcLhAlhloThlLssI..................-sss.htshps..sspoPHcphcha....hEssWtauhph...GlhLFLlplullsWlKFass................................................................hsAAhssTuIhlsssllalhaohphatshlt++tscps	............................s..as.psLSWR+L.LSR................................................................AKLKASS+TSALLSGFAMV....AMVEVQL-sspph.....P.sLLlAFosC.TTlL.VAVHLFALMlSTCILPsI.............................................EAVSNlHslsu.....lp-SPHcRhHha................IELAWuFSTsl.........GhhLFLsElsLlsWVKFhsl...................................................................u.tAAhsoTsIhlPssllFl.sFslHFYRSLVsHKp-p.t....................................	0	54	76	121
+7688	PF07857	DUF1632		CEO family (DUF1632)	Fenech M, Bateman A	anon	Pfam-B_9654 (release 14.0)	Family	These sequences are found in hypothetical eukaryotic proteins of unknown function. The region concerned is approximately 280 residues long. This family has been termed the CEO family for C. elegans ORF [1].	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.76	0.70	-5.13	6	180	2012-10-02 19:55:49	2004-08-26 09:34:15	7	7	72	0	127	161	9	207.00	32	68.02	CHANGED	GllAChlSslhFGShFVPlK+acouDGhFlQWlhShulhLVGllVauspGFPtFaPlAMLGGhhWusGNuhuVPIhssIGLulGhLlWsTssClsGWAsuRFGLFG.lssphPpsshLNYlGllllVVGGslFh.IKsp...spscscsoshphE..sshppc..sspcsSsh...c.....h.p..+p......RllshlhAlluGhhYG.hhsPlhYIpspsp....lYPsusppslsYlFSaahGIFlTSTllFlsYsIhp+NsPhlssp	.....................................................GhhushluhlhFGS.aVPlK..+hs..su....D..............G.h..............ahQWhhshulhl...........suh....l........h.h.h.................h.............t........s.....t.....F.......hPh.A.MlGGhlWus.....GNhhs.VPllptlGLulGhLlWuohshlsG..WssuR..FGh..FG..hp...p...s.t.....p...s.hL.NhhGhslsllu...shha.hh.....l..+sp........t...........p......p...p............t...........sh........t...................p..tpp....................t.....s..........................................p...................................................+h.h..uh.hulhsGhhaG..hsPh.hh.pp............hts......slsal..auah.Glhhsuohh...ahhYshhh+...t...h...t..........................................	0	58	75	113
+7689	PF07858	LEH		Limonene-1,2-epoxide hydrolase catalytic domain	Fenech M	anon	Pfam-B_15033 (release 14.0)	Domain	Epoxide hydrolases catalyse the hydrolysis of epoxides to corresponding diols, which is important in detoxification, synthesis of signal molecules, or metabolism. Limonene-1,2- epoxide hydrolase (LEH) differs from many other epoxide hydrolases in its structure and its novel one-step catalytic mechanism. Its main fold consists of a six-stranded mixed beta-sheet, with three N-terminal alpha helices packed to one side to create a pocket that extends into the protein core. A fourth helix lies in such a way that it acts as a rim to this pocket. Although mainly lined by hydrophobic residues, this pocket features a cluster of polar groups that lie at its deepest point and constitute the enzyme's active site [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.53	0.71	-4.13	7	167	2012-10-03 02:27:23	2004-08-26 09:46:28	7	2	124	7	43	472	122	120.10	39	83.09	CHANGED	ssshcsVpsFhsAhpcsDhcssltchhsssphapN.GlsshpGhscshshlcth....shsuhEhcIh+IAADGutVLTERsDthhh..Gs.hhphhVhGlFEVpss+IshWRDYFDl.shhctssc	.........................................................tshcsVpsFls.Ah..p..s..t...D..h.-...s...s.......s...s.lhs...-.................V....Y....p...N......V..u......h......s......s..l....+.........G.....t...c...t.s.t.p.h.lc.th.........pst..sG...F-.l.+.....I...H...+...I..u..A....D....G.s.s..........V.....L.......T......E........R.o............D...slh..h..........G.s.l.....+....lp..FWV..CG.V..F.E..V...c....D.G......+ITl.WRDYF.Dhhchh+u...ht...................................	1	8	30	36
+7690	PF07859	Abhydrolase_3		alpha/beta hydrolase fold	Bateman A	anon	Pfam-B_100 (release 15.0)	Domain	This catalytic domain is found in a very wide range of enzymes.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.45	0.70	-4.76	130	13075	2012-10-03 11:45:05	2004-08-29 17:28:14	8	147	3378	94	4994	21100	3681	191.50	20	57.99	CHANGED	llYhHGGGal...lGsh.sop..cshspplAptssshVlSV-YR...LA.PEa.aPAAh-DuhsuhpWlhpps.........................................t.s..hD...ss.+lsluGDSAGGNLAtslu..ltsccp........h.............lsutlLlaP...shs.............pt..tsh....t..tpt.h.l....s..tsthp.hhh.ch...Yl...s..sssts.cP.....hsuPl....hu....s...lss..LP.P.......shlhsuphDsLpD-uttYAc+Lp.t..sGVpVphh.phtGhhH.uFhh	..................................................................................llahH....G.G.......G...a.h.......h.u...s...h...pst................pth..h....p.....t......l............s..............t............t..............t.............s..............h......h......l........l....s............l...s......Y....+....................L........u...........P..............c.............t............................a...........P...........s.............s...........l........p.............D......s............h......s...........u.h.p....a.l...hpph....................................................................th.t....hc.......sp...p..l.s.l...s........Gc.S........AG..G..p..Lu.h.s.hs..........hhhp..pt......t.....t....................................................................t.s.h.l.l...h..h.P.....................hh.sh.....................t........p.h..........................t.p..............h.....h...........................s.......t......h.t..........h.....h....h....ph...............hh....s.........ttthp....p..................................h.h...s..P.h.......t.........s..................htt....h..P....s................................h.h..l..h...s.....u..t....h...D.......h...h.......s......p...s.......h...h...............h..p...t.....l.t..t...........ts.....h...............s..p.hh...h.........s...h...H.sh..t........................................................................................................................................................................................	1	1372	2820	4031
+7691	PF07860	CCD		WisP family C-Terminal Region	Yeats C	anon	Yeats C	Family	This family is found at the C-terminus of the Tropheryma whipplei WisP family proteins ([1]).	25.00	25.00	110.20	108.90	18.80	18.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.09	0.71	-4.71	2	5	2009-01-15 18:05:59	2004-09-01 16:41:52	6	2	2	0	2	5	0	110.40	83	6.06	CHANGED	hQpAK.........Pp.psh.E+...TPTESKGGGFWSKVGSGIAAPFKWIWHGITWPFRKLFGSRSEA.........................phP........phlssAVspF....................LpFL..	PS........HTQSAKPTEKPKEEK...TPTESKGGGFWSKVGSGIAAPFKWIWHGITWPFRKLFGSRSEAPSSTTNATGNTsGKTRVKRDT.ppPPEHPLKSVN-QIppVTsAVNNFQKSVLTSLKsFFTYLTDTA+LpFLp............	0	2	2	2
+7692	PF07861	WND		WisP family N-Terminal Region	Yeats C	anon	Yeats C	Family	This family is found at the N-terminus of the Tropheryma whipplei WisP family proteins ([1]).	25.00	25.00	362.20	362.20	19.80	16.80	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.88	0.70	-5.36	2	12	2009-09-11 19:29:28	2004-09-02 08:46:53	6	7	2	0	4	12	0	250.50	77	31.64	CHANGED	AhhL..SS.........psPPuLSLLSSVSpsSl.pSso+aopVS.sssp.sClosssssshhlDPlT..usotQT.oCssuhSs...pPtot....las.Yo-TsSYlYVPYIpss.l.LYY...KtsPSS.lshshoDhtTsa..........us-+VlShohososlhsLLTstNlaFa.pl.so.psplTVsl+hphcsshl.SshPuLRsS.aTaSLopPstslplDt.TGtlphS....olsspslTAhAlphsTuThlT..YhhDo.h.	LT..LLLLSSLQYETAFARQTPPALSLLSSVSSTSV.SSNTKYTRVSNTNTQEVCVTTNTNVSLLIDPVT..SSTKQTLSCTPSLSP...QPQTH....IYVPYTDTSSYLYVPYITNTHISLYYTDKKADPSSFLTFPHTDIATPY..........GDEKVlSITKTTTNLIALLTTRNIFFF.DIHVTEKPKITVPIHKQIDNTYL.SDIPSLRNSRYTFSLTHPNKDITIDRYTGQIHLS....SLPTSPITAIAIN+DToTHIT..YAlDo...ss...	0	4	4	4
+7693	PF07862	Nif11		Nitrogen fixation protein of unknown function	Yeats C	anon	Yeats C	Family	This domain is found in the Cyanobacteria, and may be involved in nitrogen fixation, but no role has been assigned ([1]).	22.90	22.90	23.10	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.17	0.72	-4.02	116	396	2009-09-14 15:19:10	2004-09-02 09:07:36	6	4	112	0	200	413	401	48.80	26	53.68	CHANGED	MStcp....LcsFLpcl.p.........sDssLppplpu..st.st-plltlApptGaphotc-lt	.............MS.cp....lctFlpcl.p..........sDssLpcplps......sp..ssccl....ls....l..A....pptGashotc-l..............	0	34	83	179
+7694	PF07863	CtnDOT_TraJ		Homologues of TraJ from Bacteroides conjugative transposon	Yeats C	anon	Yeats C	Family	Members of this family have been implicated in as being involved in an unusual form of DNA transfer (conjugation) in Bacteroides ([1]). The family has been named CtnDOT_TraJ to avoid confusion with other conjugative transfer systems.	25.00	25.00	25.00	25.00	24.40	24.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.38	0.72	-3.51	15	330	2009-01-15 18:05:59	2004-09-02 09:22:06	6	2	117	0	39	273	4	62.30	53	19.65	CHANGED	FMIIGIlGYFTlPTVuuWIIpAGGu.GuYu+sVNptut+uGssA.......uusuGAAhGssuG+lp..............u+	....FhlIGIlGYFTlPTVAGWIIQAG.Gs.GuYuR..NVNpsAs+uushA........uusAGAssGNhuGRl...th.......................	0	20	36	39
+7695	PF07864	DUF1651		Protein of unknown function (DUF1651)	Yeats C	anon	Yeats C	Family	This is a family containing bacterial proteins of unknown function.	20.40	20.40	20.80	20.70	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.40	0.72	-3.88	45	133	2009-01-15 18:05:59	2004-09-02 09:34:00	6	1	30	0	51	136	674	70.90	25	80.29	CHANGED	pGWLlssppphlhpFc...-ppohpt.s.tlhlcphchhs...upPslhcs+c+l.phcpAhctWccLlpsGWpcs.ps.hs	................sWLlssp...pphlhpFp.....spp.s.p..s.hlhlcphphhs......spPslh+spcch.ph-pAhchWppLhppGWpps.p..h........	0	2	20	42
+7696	PF07865	DUF1652		Protein of unknown function (DUF1652)	Yeats C	anon	Yeats C	Family	This is a family containing hypothetical bacterial proteins.	21.30	21.30	21.30	25.20	21.20	19.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.04	0.72	-4.37	16	126	2009-01-15 18:05:59	2004-09-02 09:42:41	6	1	42	0	31	125	0	67.00	32	78.74	CHANGED	hh-lRpllEpuFLPhpCpCohssstshTl+lh.-ssSGclpLhloGluhppLposRDlspLlspL+t-hs	........phppllEtuFhPhtCpsohssstoMsl+Lh.D.sSGcp.lslsGlshuplhoucDlscLltpl+p-h.....	0	0	0	20
+7697	PF07866	DUF1653		Protein of unknown function (DUF1653)	Yeats C	anon	Yeats C	Family	This is a family of hypothetical bacterial proteins of unknown function.	21.80	21.80	22.10	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.26	0.72	-3.79	54	591	2009-01-15 18:05:59	2004-09-02 10:42:42	6	8	565	2	154	512	59	62.70	44	59.86	CHANGED	sGhYRHYK.........G.s.YcVlulA+HSETcE..lVlYcsLYG-h..ulWVRPhsMFhEsVpl.-GpplP......RFphl	............................................shYRHa.K............G..shYpVlsl.Ac...HSETpE..pl..VlYpsLY.....u-h...ulWVRPhsMFhEp.V.h..Du..pphP......RFph...................	0	48	101	131
+7698	PF07867	DUF1654		Protein of unknown function (DUF1654)	Yeats C	anon	Yeats C	Family	This family consists of proteins from the Pseudomonadaceae.	20.90	20.90	21.10	23.50	20.60	17.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.47	0.72	-4.61	12	129	2009-01-15 18:05:59	2004-09-02 10:55:33	6	1	57	0	18	103	2	71.10	37	83.43	CHANGED	s.ouhE+LGhRlpchINuPsAQcpRhslIaRL-s-up--WEpllptlsEs-slsLsap.DDGuVpltWph.p--	..s..puY-tLuhRlQ+.lIsuPsAQpp+tsllhRhssEspccWsplL-pIuEs-slplshp.-DGo.VpltWph.........	0	1	1	12
+7699	PF07868	DUF1655		Protein of unknown function (DUF1655)	Yeats C	anon	Yeats C	Family	This protein is found in some prophages found in Lactobacillales lactis ([1]).	19.20	19.20	19.90	110.70	18.20	17.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.73	0.72	-3.98	2	18	2009-01-15 18:05:59	2004-09-02 11:17:53	6	1	12	0	3	13	0	54.70	80	86.09	CHANGED	aI..Dphth.hh-hL.A+ARHaIcls-hs.+LFDGpSVsTFThhtNshQVEh.cu	YILDDSIAFELMDLLKAKARHFIQLNEYVYRLFDGQSVVTFTTLENDIQVEMVKG.	1	2	2	2
+7700	PF07869	DUF1656		Protein of unknown function (DUF1656)	Yeats C	anon	Yeats C	Family	This family contains bacterial proteins, many of which are hypothetical.  Some proteins in this family are putative membrane proteins.	21.30	21.30	21.30	21.50	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.83	0.72	-4.18	72	1584	2009-01-15 18:05:59	2004-09-02 11:23:22	7	4	929	0	230	607	18	58.50	37	80.14	CHANGED	pElslhGlahPslllhhllAhslshllctlLschshaRhlWH.uLFcl...uLalhllus.l	.........lslhGlhF.PPlFhthlluh.slahll+RlLtshthhch.lWHPuLFsh....uLashlhsL.............	0	34	89	154
+7701	PF07870	DUF1657		Protein of unknown function (DUF1657)	Yeats C	anon	Yeats C	Family	This domain appears to be restricted to the Bacillales.	24.00	24.00	24.70	27.40	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.07	0.72	-4.28	27	523	2009-09-11 09:19:45	2004-09-02 11:26:35	6	3	182	0	90	296	1	49.90	36	36.63	CHANGED	pl+psl.AuLKuspAsLcsauLpTcsppAKphappsupphcpllpslpsRl	.........l+psL.AuLKusp...AsLEsFuLsTcsppAKphappsApphppIlspLpsRl.....	0	30	66	74
+7702	PF07871	DUF1658		Protein of unknown function (DUF1658)	Yeats C	anon	Yeats C	Family	This family of small proteins seems to be found in several places in the Coxiella genome.	25.00	25.00	25.20	34.20	22.70	24.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.92	0.73	-7.26	0.73	-4.18	7	73	2009-01-15 18:05:59	2004-09-02 11:31:08	6	2	6	0	19	34	0	30.10	42	65.46	CHANGED	sslKshcs.uhsp+PhtGssstahshhhh.	sslKshcs.uhsp+PstGNsssahshhhh.....	0	19	19	19
+7703	PF07872	DUF1659		Protein of unknown function (DUF1659)	Yeats C	anon	Yeats C	Family	This family consists of hypothetical bacterial proteins of unknown function.	20.70	20.70	20.80	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-8.03	0.72	-4.33	20	335	2009-01-15 18:05:59	2004-09-02 11:35:22	6	1	251	0	81	255	0	46.30	31	62.86	CHANGED	spshsosLhLchpsGls.ssGcPlh+s+oaspVKssAscpDlYsVApA	.................s...hstsLtLhhpsG.lD.psGcslh+s+sappVKssAs.-plasVApA..............	0	38	70	76
+7704	PF07873	YabP		YabP family	Yeats C	anon	Yeats C	Family	This family of proteins is involved in spore coat assembly during the process of sporulation [1].	21.40	21.40	21.40	23.10	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.79	0.72	-4.41	73	814	2009-01-15 18:05:59	2004-09-02 11:39:05	6	1	421	6	177	539	9	66.30	30	70.00	CHANGED	hsplolpu+pclhlpsh+slhsFsspclhlpTphGhLhI+GcsLplpplss-p..ltlpGpIpslpY.	...............clslhG+ppl.Ipsh+slhsFsscclhLp.TphGhLtI+GpsLplcplssEc..ltlcG.pIpsltY......	0	93	147	157
+7705	PF07874	DUF1660		Prophage protein (DUF1660)	Yeats C	anon	Yeats C	Family	This protein is found in Lactobacillae prophages.	21.40	21.40	21.60	21.60	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.75	0.72	-3.69	9	38	2009-01-15 18:05:59	2004-09-02 11:54:19	6	1	30	0	7	29	0	60.00	40	93.52	CHANGED	MKLhCKLFGHKW-....hsPhsphcs.aCtRC.........................saNRSDLDESENVFP...EKWLDKHMD	..MKLhCKL.FGHKWp.........ssshpphhc.tCpRC............htp..pt.....h.hNRSDLDES-sha....c.............................	0	2	4	6
+7706	PF07875	Coat_F		Coat F domain	Yeats C	anon	Yeats C	Domain	The Coat F proteins, which contribute to the Bacillales spore coat.  It occurs multiple times in the genomes it is found in.	23.80	23.80	23.90	23.80	23.60	23.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.58	0.72	-3.84	65	780	2012-10-01 21:25:29	2004-09-02 11:54:34	7	2	357	0	179	551	2	63.60	24	50.09	CHANGED	sDcsl.sschLsstKsssssYusAhsEsssPpLRpsltptlspshphphplaphhhpKGaYps.p	......sDpsh.ss-hLsshKtsspsYupslsEssssplRpsL.pphhsps.phptplaphhhpKGaYts...............	0	81	147	156
+7707	PF07876	Dabb		Stress responsive A/B Barrel Domain	Yeats C	anon	Yeats C	Domain	The function of this family is unknown, but it is upregulated in response to salt stress in Populus balsamifera ([1]). It is also found at the C-terminus of an fructose 1,6-bisphosphate aldolase from Hydrogenophilus thermoluteolus (Swiss:Q9ZA13; [2]). Swiss:Q93NG5 is found in the pA01 plasmid, which encodes genes for molybdopterin uptake and degradation of plant alkaloid nicotine. The structure of one has been solved (Swiss:Q9LUV2) and the domain forms an a/b barrel dimer ([3]). Although there is a clear duplication within the domain it is not obviously detectable in the sequence.	21.20	21.20	21.40	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.10	0.72	-3.54	51	1481	2012-10-02 00:20:33	2004-09-02 12:33:13	7	15	921	48	686	1398	234	96.20	21	80.22	CHANGED	lcHlVha+h+csssspph..tph....hpshpsL........splsslpphp..hGtshsspp.....ttu.ashshhspFcshpsh.csYts.cP..........tHhphs.phhpshhp....phhshDaps	.........................lpHlVha+h+..psss....tpph......tph.......hpth..psL....................spl..s.t.l..t..p...hc....sG..hshs.sps...................pu.ashslhspFpstcsh.pt.Yts..HP..........t.Hht..ht..phh...ts...h.h..p.....phh.shDa.....................	0	173	439	571
+7708	PF07877	DUF1661		Protein of unknown function (DUF1661)	Yeats C	anon	Yeats C	Domain	This is a family containing bacterial proteins of unknown function.  Many of the proteins in this family are hypothetical.	25.00	25.00	25.60	25.60	23.10	22.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.87	0.72	-7.22	0.72	-4.45	9	52	2009-09-11 10:00:21	2004-09-02 13:59:39	6	2	3	0	9	48	0	29.80	45	32.42	CHANGED	LsR-hhssRA+TKKFSR+hh...RphsspotpFR	LsREhKpSRApTKKFS++hh...+php.p.t.hh............	0	9	9	9
+7709	PF07878	DUF1662		Protein of unknown function (DUF1662)	Yeats C	anon	Yeats C	Domain	This family contains bacterial proteins of unknown function. This domain belongs to the Ribbon-helix-helix superfamily suggesting these may be DNA-binding proteins.	22.20	22.20	22.30	22.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.52	0.72	-4.23	27	70	2012-10-02 18:44:02	2004-09-02 14:12:51	6	1	32	0	30	72	224	51.30	31	59.07	CHANGED	usps+SsRlpVlLPppls-cLpthAcpEuRosSs......hAclLIpcGlpRhtst	.....stscsshIpslLPcplsccLpthApp-uRosus......hAclLlpculpRtht.....	0	2	10	24
+7710	PF07879	PHB_acc_N		PHB/PHA accumulation regulator DNA-binding domain	Yeats C	anon	Yeats C	Domain	This domain is found at the N-terminus of the Polyhydroxyalkanoate (PHA) synthesis regulators. These regulators have been shown to directly bind DNA and PHA ([1]). The invariant nature of this domain compared to the C-terminal Pfam:PF05233 domain(s) suggests that it contains the DNA-binding function.	25.00	25.00	25.70	36.80	21.60	20.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.97	0.72	-4.24	47	465	2009-01-15 18:05:59	2004-09-03 09:55:21	6	3	457	0	198	441	191	63.80	56	33.74	CHANGED	plIKKYsNRRLYDTpoSpYlTL-cltphVhpup-FpVlDAKTG-DlTRslLhQIIhEpEs..tGp.s	...lIKKYsNRRLYcTpTSoYlTL-DltphVhcuE-FpVhDAKoG-DLTRolLhQIIhEcEs.tG..s.....	0	60	127	160
+7711	PF07880	T4_gp9_10		Bacteriophage T4 gp9/10-like protein	Fenech M	anon	Pfam-B_73396 (release 14.0)	Family	The members of this family are similar to gene products 9 (gp9) and 10 (gp10) of bacteriophage T4. Both proteins are components of the viral baseplate [1]. Gp9 (Swiss:P10927) connects the long tail fibres of the virus to the baseplate and triggers tail contraction after viral attachment to a host cell. The protein is active as a trimer, with each monomer being composed of three domains.  The N-terminal domain consists of an extended polypeptide chain and two alpha helices. The alpha1 helix from each of the three monomers in the trimer interacts with its counterparts to form a coiled-coil structure. The middle domain is a seven-stranded beta-sandwich that is thought to be a novel protein fold. The C-terminal domain is thought to be essential for gp9 trimerisation and is organised into an eight- stranded antiparallel beta-barrel, which was found to resemble the 'jelly roll' fold found in many viral capsid proteins. The long flexible region between the N-terminal and middle domains may be required for the function of gp9 to transmit signals from the long tail fibres [2]. Together with gp11, gp10 (Swiss:P10928) initiates the assembly of wedges that then go on to associate with a hub to form the viral baseplate [1].	25.00	25.00	25.30	25.20	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.74	0.70	-5.34	14	97	2009-01-15 18:05:59	2004-09-03 14:03:50	6	3	54	22	1	90	685	229.60	30	52.13	CHANGED	KphIclGslsssuTGDhLhcGGsKlNsNhsplYsthGDtc.................l.HAsGhap+aups.............hshsl.hGstasIDTo...sGs.lsVsLP+.....G...chGcslchhsssGShu....sNPlslhstuGDoIcG.ssss..hplspsasclpLhhsusu.......pW-Y....pl-slhssshssVscphh.IsssspTD.lslFs.pspYNsspLhVhtcss......sshhhpssp.hh.ls.sps...scVhss-h.ssl+ht...tsssDplh.lsah..sG..lhshhSS.tspsl+l	....................KphIslGphss-uTGDhLhcGGpKINsNFsplYsthGDsc..................h.ausGhapphsts.............................hssthGp.aslsTo...sut.lsl..plsc.....G....chscslchhss.uohs....spsltl..tssDolt...G.ssss.....h.lspsa.clplhhhuss.......hWpY....plpphhssc.ssltpp...ltststss.lsl...ht.tspYshhpl.Vhtpss......s...hptsp.hh..s.t.s......splhsh-h.tsh+ht....p.tDp.l..hsa...ss..l.thhps..t.th...................................................................................................	0	0	0	1
+7712	PF07881	Fucose_iso_N1		L-fucose isomerase, first N-terminal domain	Fenech M	anon	Pfam-B_11456 (release 14.0)	Family	The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis,  and converts an aldo-hexose to a ketose to prepare it for aldol cleavage. The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta-sheets with surrounding  alpha helices. Domain 1 demonstrates the beta-alpha-beta-alpha- beta Rossman fold. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting  residues, and domain 1 from the adjacent subunit contributing some other residues [1].	25.00	25.00	29.00	28.90	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.84	0.71	-4.73	17	960	2009-01-15 18:05:59	2004-09-03 16:01:50	7	3	940	15	59	415	11	163.90	70	29.68	CHANGED	tshP+IGIRPsIDGRchG..VRESLEtpTMpMA+ulAcLlpssl+assGssVECVIADssIGusuEAAtsuc+FpppsVslTlTVTPCWCYGoEThDMsPhhPKAlWGFNGT..ERPGAVYLAAshAuHsQ+GlPAFuIYG+-VQDscDpsIPpDVpEKlLRFARAulAVupM+G	.....s..hPKIGIRPsIDGRRhG..VRESLE-QTMNMAKusAsLloppL+assGssVECVIuDosIuGhAEAAACcEKFpppNVGlTITVTPCWCYGSET..lDMDPshPKAIWGFNGT..ERPG...AVYLAAALAAHuQKGIPAFuIYGHDVQDADD.T.oIPsD..VcEKLLRFARAuLAVAoM+G................	0	22	41	49
+7713	PF07882	Fucose_iso_N2		L-fucose isomerase, second N-terminal domain	Fenech M	anon	Pfam-B_11456 (release 14.0)	Family	The members of this family are similar to L-fucose isomerase expressed by E. coli (Swiss:P11552, EC:5.3.1.3). This enzyme corresponds to glucose-6-phosphate isomerase in glycolysis, and converts an aldo-hexose to a ketose to prepare it for aldol cleavage.  The enzyme is a hexamer, with each subunit being wedge-shaped and composed of three domains. Both domains 1 and 2 contain central parallel beta- sheets with surrounding alpha helices. The active centre is shared between pairs of subunits related along the molecular three-fold axis, with domains 2 and 3 from one subunit providing most of the substrate-contacting residues [1].	21.30	21.30	21.50	21.40	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.03	0.71	-4.63	21	1038	2009-09-11 15:21:47	2004-09-03 16:04:42	7	4	952	15	63	438	21	167.00	60	30.95	CHANGED	+oYLshGuVSMGIuGSllss-FFpcYLGM+sEtVDhoEllRRh-ptIYDp-Ehc+AhtWlccps+..cGcDpN..Pcchpps.cpp....ct.ac.llKMhhIhRDlMtGN.+LtphGatEEuhG+NAlsuGFQGQRpWTDaaPNGDhsEAhLNosFDWNGhREPalhATENDoLNuluMLFs+LLTss	..........................KSYLShGuVSMGIAGSIVspsFFppaLGM+spuVDMTElpRRlDptIYDc.tE...hEhALuWsccsh+....G.DpN...............scphpcstE.pp....ct.hc.slhMsMhhRDhMpGNs+LA-hGhhEEulGaNAIAAGFQGQRpWTDpa.PNGDhhEAlLNoSFDWNGlRcPFVlATENDSLNGVuMLhG+.LTsT......................................................	0	24	43	52
+7714	PF07883	Cupin_2		Cupin domain	Bateman A	anon	Pfam-B_81 (release 15.0)	Domain	This family represents the conserved barrel domain of the 'cupin' superfamily [1] ('cupa' is the Latin term for a small barrel).	21.50	21.60	21.50	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.47	0.72	-4.47	156	20335	2012-10-10 13:59:34	2004-09-06 15:00:03	6	127	4001	229	6298	26569	7119	70.00	18	38.76	CHANGED	hhhpltPGs.sss....Hh.H.ssp...EhhaVlpGc.hplp.ls...up...phhlpsGDshhhss.s..h.Hph.tN....susp.ssph...lslh	............................................h....h.sGt..ths.........+t...H..st.......p......ch.h..h....V...l...p..G..p...h..p....l....p...l.s.................sp.............pht..l..p..s...G..D...s........l..h...h.s.s..s.............h..Hth...ts.........s....pt...h.h...h...h..................................	0	1857	3867	5218
+7715	PF07884	VKOR		Vitamin K epoxide reductase family	Bateman A	anon	[1]	Domain	Vitamin K epoxide reductase (VKOR) recycles reduced vitamin K, which is used subsequently as a co-factor in the gamma-carboxylation of glutamic acid residues in blood coagulation enzymes. VKORC1 is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea [1]. Four cysteine residues and one residue, which is either serine or threonine, are identified as likely active-site residues [1]. In some plant and bacterial homologues the VKORC1 homologous domain is fused with domains of the thioredoxin family of oxidoreductases [1].	21.00	21.00	21.30	21.20	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.10	0.71	-4.32	38	864	2009-01-15 18:05:59	2004-09-06 15:44:38	9	18	670	1	380	845	319	134.20	23	51.63	CHANGED	tthhhhlhuslGllsShhlshpchshhp....hhshCsls...ssluCu..pVhsS.husl..FG.............hPsullGllsassll.shulhhhh...........phschhh.hslhhsshsuslhshaLhal.h..ahIp.uhChaChssaslolslhllshhts	...........................................t..hhhhhhuhlGlhhohhls.h...chphhp................h.shCs.ls........shh..uCspV.hs.S..uph....aG...............hPsuh..hGlhhaslhl.shuh.h...hh........................phsphhh...hhlhhu..s.h.hus..s.h..sh..aLha..h......ah.lt.shC.aChsshshshslhhhsh..t................................................	1	129	240	313
+7716	PF07885	Ion_trans_2		Ion channel	Bateman A	anon	Pfam-B_55 (release 15.0)	Domain	This family includes the two membrane helix type ion channels found in bacteria.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.87	0.72	-4.26	123	9163	2012-10-03 11:11:44	2004-09-08 16:19:51	11	158	2837	170	4782	12148	1623	81.40	21	22.30	CHANGED	hhlhhhhhhushhhhh..............t..h....shhs.ulYashsoloTlGYGD.l...sPt.sss.....t.......+lhs.hhhhhhGlshhshhlshhsphhhp	...............................................................hh....hhhh..uhhhh.h................................................t..t.h..s.hh....s...uh.Ya............s.hlTho..Tl...G..........Y......G..D..l.....sPt..oth..........u..................................+lhs...hhh....h.l.h.....G.l.s..hhshh.h.shlsphh..t.......................	2	1860	2647	3883
+7717	PF07886	BA14K		BA14K-like protein	Fenech M	anon	Pfam-B_4068 (release 14.0)	Family	The sequences found in this family are similar to the BA14K proteins expressed by Brucella abortus (Swiss:Q44701) and by Brucella suis (Swiss:Q8FVU0).  BA14K was found to be strongly immunoreactive; it induces both humoral and cellular responses in hosts throughout the infective process [1].	21.70	21.70	21.80	23.10	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.50	0.72	-4.27	58	605	2009-01-15 18:05:59	2004-09-09 13:46:19	6	5	152	0	174	430	7	30.90	47	18.05	CHANGED	sahpaCspRYRSYcPsssTY.sas.G.R+.C.	....HlpaChsRYRSYcspDsTYQPas.GsR+tCh.......	0	13	69	96
+7718	PF07887	Calmodulin_bind		Calmodulin binding protein-like	Fenech M	anon	Pfam-B_4579 (release 14.0)	Family	The members of this family are putative or actual calmodulin binding proteins expressed by various plant  species. Some members (for example, Swiss:Q8H6T7), are known to be involved in the induction of plant defence responses [1]. However, their precise function in this regards is as yet unknown.	21.00	21.00	21.50	22.10	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.87	0.70	-5.37	11	283	2009-01-15 18:05:59	2004-09-09 13:48:24	6	6	26	0	157	262	0	252.30	37	49.84	CHANGED	plpLtFhspL..phPlFTGuKlEucsGsslclsLlDssTs.....lssGst......SshKlEllsLcGDFsstpc.-pWTsEEFppp.IV+pREGKRPLLsGslpVsLps.Glusl.u-lsFTDNSSWhRSRKFRLGsRVsss...sGlRlpEAho.EuFsV+DHRGE.....................................LYKKHaPPhLpDEVWRLEKIGK-GAaH++LssptIsTVc-FL+hhshDss+LR.pllGssMSs+hWcshlcHA+oClLus.clalYp....spssslhFNslaEllGlhhsspahs..hcsLsphppshl...........cpLlppAYpphspl.ph-schhhshs	............................................................................................hpLpFhspl....sl.FTss+lpu-pusslclsL.hDssst.....hlssGs.......ushKl-llVL-G...DF....ss...cp....p...ps..W...T...t..--F...psp...lV..pt....RpGKcPLL..........s.........G.........-..l..lpLcp...Ghusl..s-lpFTDNS.S.a.h.RS.....RK...FRLGs+.ls....s....s.....tuh...Rl...pE....Aho.-sFsV+D+RG.E.....................................hhKK+aPPtL..pD-VaRL-+IuKc...............G........s.hH.+.........cLp................p......t...............tI.oVp-FLph.h..h...h..c.............p..cL..R....p..............lLG.....thS.s+hW-shlcHA+.sCslss...c.ha..hYh........ttpphslhFNslhphhGh.....h.s.tp.hhs...pplsp.pp..s..............pthhppAYpph.pl.tht.......................................................................................................	0	20	89	126
+7719	PF07888	CALCOCO1	CoCoA; 	Calcium binding and coiled-coil domain (CALCOCO1) like	Fenech M, Mistry J	anon	Pfam-B_4504 (release 14.0)	Family	Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1, Swiss:Q8CGU1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1 (Swiss:Q61026), and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region [1].	30.00	30.00	30.00	30.00	29.90	29.70	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.79	0.70	-6.22	3	312	2009-01-15 18:05:59	2004-09-09 13:50:00	6	6	55	0	115	266	0	340.20	34	63.29	CHANGED	spp+tGVsFLNVA+TYlPNTKVECHYTIPsGpcsSoRDWIGIFKVssuoVRDYaTFVWAlsPEuss-GSsuHCSVQFQASYLP+PGsQpYQFRYVDppGsVCGpSssFsFuEPRPMDELVTLE-....EDuGsDlLLVVPKATlLQNQLEtuQ+ERNDLM+t+LALEG-V..................o-hRSRIppLEsALcpScccspELcEQaK-lsoScpphouERNlLssQcAEpppRILELEsDIQTlocKh..................pEp-+lLtthp-IcA-LEppKuELp...........................QRLK-pTlQh+Dp.spt.chQLElEsL+EcLRouQEhLuSSQQKAsLLGEELAShuSlRD+TIAELH+SRLEoA-lul+LS-LuL+LKEGpuQWuQERsuLpQSsEA-KD+IlKLSAElL+LEcuLQEERSQRcsLcsELupEKDuspVQLSEs+RELoELRSALRVLQKEKEQLQEEKQELL-YlR+LEtRLDKlADEKWsEDAs..lsEDccuulshosslDLoDS-DESPtDEu.SpcLuPsuLDEcscstSoPssP+Espc.VVIsQPAPIuPaLSGlAEDssS-	.............................hu.....tV.F.sVs+.YlPpsplpC+YTLs.hhhPpspDWlGIFK..........V........GW....sos.RDYaTFlWu.sh........P..-s..hspsoshpp.pVtFp....................u.YLP.p.s....ss..p.hYQF.sYV.spp.Gp.lpGsSsPFQ.....FR..s..p.s...-..L....l..shpp.................t.t.pDh.Llls...+....s.t.....h...p.........plc..c........pEpp-.....Lh...p......Lptph...........................tp.hppphtph....ptthtptpp...p........htpL.t.t..p..th........p........t..t.....h.......p.....Epp.............h...........p..........tc.........tch....hp.Lc....pp......thppp................................................t..............t.........p..................phpt.....t.....................................................pht.............p...hp................t......................................p.......................................................................................................................................................................................................................................................................................................................................................................................................................................ttt................................................................................	0	16	26	55
+7720	PF07889	DUF1664		Protein of unknown function (DUF1664)	Fenech M	anon	Pfam-B_4797 (release 14.0)	Family	The members of this family are hypothetical plant proteins of unknown function. The region  featured in this family is approximately 100  amino acids long.	30.00	30.00	30.00	30.40	29.80	28.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.67	0.71	-4.33	14	118	2009-09-11 16:08:29	2004-09-09 13:51:16	7	2	27	0	61	110	0	120.00	38	37.07	CHANGED	uoG.hshhll.ssslGAlGYGYhWWK............GhphsDlMaVT++shusAssslsppL-plp-slsusK+HLopRIpplDc+LDppp-ltcpspc-VstlppslssIpcDlcslppslpsLcuKlsplEtpQ	..........s..sshs.hllsssslGAl..GYuYhW.WK............GhphoDlMaVT+RshusAssslsKpL-pVssuluusK+HLo...pRIpplDp+l-cpt-lspthcc-V..stl+tslspItpDlpslpphVpsL-sKl.splEtpQ...........	0	14	37	50
+7721	PF07890	Rrp15p	DUF1665; 	Rrp15p	Fenech M, Mistry J, Wood V	anon	Pfam-B_9434 (release 14.0)	Family	Rrp15p is required for the formation of 60S ribosomal subunits [1].	21.60	21.60	22.60	22.10	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.04	0.71	-4.10	32	310	2009-01-15 18:05:59	2004-09-09 13:52:49	7	4	276	0	216	307	1	139.90	30	50.85	CHANGED	uausuhspILu...........o+htsssps..PILu+sKchh...cphps-cLEpKA................................................ct.hhpEK+phhp+sRV+s..........ls...............................phh-pE+pL+Kl...........Ap+GVV+LFNAVpssQhpsccthpct.ptpphh............................cchl...sc...lSKcpFLDll...............pu	...............................................................................uausuhscILs............pchspspps..slLu+sKphtt....cc....hp..p-c.lEp+s.......................................................................pt.h.tpcK+ph.ppsRl+ssls..................................................................pst-pE+pL++l...........Ap....+GVVpLFNAVpptQtps.p.c.t.h.c.cs.t.t.p.tppt.................................................pchl.....sp..lSKpsFL-hlp.u.........................................	0	72	115	177
+7722	PF07891	DUF1666		Protein of unknown function (DUF1666)	Fenech M	anon	Pfam-B_9387 (release 14.0)	Family	These sequences are derived from hypothetical plant proteins of unknown function. The region in question  is approximately 250 residues long.	25.00	25.00	33.00	32.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.81	0.70	-4.96	6	77	2009-09-10 15:06:31	2004-09-09 13:54:16	7	2	16	0	50	75	0	227.60	41	40.08	CHANGED	ppDLEhVYVGQlCLSWEhLaWQYcKAh-lhE...cD.ash+pYNpVAGEFQQFQVLLQRFVENEPFQ.GPRVpsYlRpRClh+shLQVPsIR.pDctKsKKssRcE....ppD.sIoospLsEIlcEohplFWcFLRADKccusl.slKuhptoQhp.....DssDlELhhplKpchQK................KE++L+-lhRSssCIlKKFpKpcpcp...sps.hFhutl-LKLVoRVLsMs+lsp-cLtWCpcKLs.........................KIshssR+..lphEsSFsLFPs	.....p-LEtsYVuQlCLoWEhLpWpYpphpchhp...........sss..p..ssp.pasplAtcFQQFQVLLQRFlENEPFE.G........RschYsRtRshh.pLLQVPph+.t-p...p-cpp.tpp......t.c.hIsuspllcIhEEoIpsFhtFl+sDKcpss....hhpshhpp..p..hp.....ssh-.pLltp.lppshpK.................Kch+LK-lh+stpshh++hhptp.......pchphhhu.lDlKlVoRVLpMscloc-QLhWCccKhs.........................Klph..h.pt+..lph-.sS..lhFP........................	0	6	33	42
+7723	PF07892	DUF1667		Protein of unknown function (DUF1667)	Fenech M	anon	Pfam-B_9631 (release 14.0)	Family	Hypothetical archaeal and bacterial proteins make up this family. A few proteins are annotated as being potential metal-binding proteins, and in fact the members of this family have four highly conserved cysteine residues, but no further literature evidence was found in this regard.	20.20	20.20	20.30	20.60	20.00	19.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.58	0.72	-4.29	35	405	2009-01-15 18:05:59	2004-09-09 13:57:04	6	5	308	1	112	341	7	80.60	40	59.44	CHANGED	sRGhcYAcpElpsPpRllTooV+lpsGc.hshlsVKTccPIPKchIh-sM+tLpplpVpAPV+lGDVllcNlhsTGlcllAT+	.............RGttYucpElssPpRllTooV.+.l..c..........uGp.hshlsVKTpcsIPKpplh-shctLpp...lpV...pAPV+hGDVllcslhsTGVDllAT+...............	1	63	88	101
+7724	PF07893	DUF1668		Protein of unknown function (DUF1668)	Fenech M	anon	Pfam-B_5066 (release 14.0)	Family	The hypothetical proteins found in this family are  expressed by Oryza sativa and are of unknown function.	21.30	21.30	21.50	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.58	0.70	-5.32	43	450	2012-10-05 17:30:43	2004-09-09 14:01:57	8	10	10	0	256	374	0	265.40	19	82.32	CHANGED	RRalaLllcstt.ts.....asl++lD...........................................s.stssssssthpthpLP.sshhph...................tshpFhsl.....sss+llus.....-ts.........sp...shlYDssspsVt.................shPs..Ltp.PKhhP..lulsl.................Gss.LY......lh-pssps..ss..........pFEsl....shp...............tttcsWsWps.....L......PP.PP.......Fststp..............lsuYAVV.....sG....spIhlooss.........................G........TYuFDTssp..p.....Wp+h...G-W.tLPFpGpAcYVs..EhsLWhGlussstt.....hl.sAsDlsusst........pP.hh..hthh........chtsP.....................hsupLlpL.G.uG+FCls+hhpst.................................t.stppttspphhshlTulcl...........................stspsspLchlp++up.pa	...............................................................................................h.phs.............................................................................................................hP.....hph....................hphh.h...........tstllsh........s.t....................tt...shlaD..sttt.....thh............................hPt.......h.t..sp..h...s...h.h.h...........................................................ssp..la......hhpt....................Fcsh...ht..........................ththp............lPs..P.P...a.h...............................ltuaslh......s....pp.lhlShtt...............................G........Tash...D......s..pt...t.....Wpph....GpW..LP.F..G...pu.ass..ch.t..hahGlstts............l.suhslss........................h.....................th...........................ts.lh.h.G...su.....paChhchh........................................................hh.h.hhth.......................................................................................................................................................	1	0	55	167
+7725	PF07894	DUF1669		Protein of unknown function (DUF1669)	Fenech M	anon	Pfam-B_9335 (release 14.0)	Family	This family is composed of sequences derived from hypothetical eukaryotic proteins of unknown function. Some members of this family are annotated as being potential phospholipases but no literature was found to support this.	36.60	36.60	36.70	37.60	36.40	36.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.84	0.70	-5.21	23	379	2012-10-02 13:01:53	2004-09-09 14:15:35	7	3	44	0	217	312	0	254.00	40	43.34	CHANGED	L--spsp.csstu....psphhYsEptRLAl-sLLpsG.cAapphLppEplhcFLSspElptlhpssph.pssscp...........................tt..sttpstssst-su.....SsTYaPttS.Dt-sP.sLDLGWPs..sssa+GsT+lslahQP..sh.cspssIKEllR+hIppApcVIAlVMDlFTDlDIhpDLl-Aup+RpVsVYlLLDpsslstFLcMCp+hplshpcl+...........NlRVRoVsGssahs+oGp+hpGplpcKFlLlDsc+VhoGSYSFoWosu+lcRs....hlplhoGplVEtFDcEFRpLYApSpsl	................................s.....t.hasEttRLAl-sLlptG.cAahphLppEph...hsFLSt.Elphlhpphpt.....t..s.st.t..................................t..t..s.t....s..tstsss........ShTYaP.tS.DhpsP.tL-LGWPt...psshpGhTcsslahQP...s....spt.sIK-hlRphIppA.ppV.lAlVMDhFTDlDIhpD.ll-Au.+.RtV.sVYlLLDptslphFLcMspchp...lp.t+..l..c...........NhRVRolsGssahs+oGp+.hpGplppKFlllDscpVhsGSY.S.FoWo.su+hcps....hlhlhoG.plVE.FDcEFRpLYAtSps..............................	0	8	29	86
+7726	PF07895	DUF1673		Protein of unknown function (DUF1673)	Fenech M	anon	Pfam-B_4746 (release 14.0)	Family	This family contains hypothetical proteins of unknown function expressed by two archaeal species.	22.90	22.90	23.10	23.50	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.56	0.71	-4.79	23	47	2009-09-14 08:49:41	2004-09-09 14:24:15	6	4	14	0	41	45	6	189.10	18	76.51	CHANGED	hhhh-pIKKLMGWCPNA+shEs.ppphs.psF-usstscuc.tpssshcssuhap+t....psphLlhshhhThhhh.lhls.hGlsh......hhLLhGhhlu...Lhhhlhs..................WKtphppa-ultcp.lhcsssKpph.....lhhlhhhlhhhhhhh..hh.t.h.tthshpsllSF...........................luGhhlh.hWlhYhQllYWEKKN+phlahcppps....pchYllsE+p	.......................................................c.I++hMGWCPsspt.ps.tpphs.t.hcht..ptst..psts.hs...thhp+h....psphLlhshhhohhhh..lhl..hulsh................hhllhGhhhs...Lhhhlhs....................a+p.hppac..shtph.lhpsp.+pph.....hh.hlhhhlhhhhhhh.......h...hs.phhhuh.............................hsuhhlh..hahha..hphhhacc..+pphhlhhppp.t.....t.hhh.tc...........................................................................................................	0	15	21	21
+7727	PF07896	DUF1674		Protein of unknown function (DUF1674)	Fenech M	anon	Pfam-B_4326 (release 14.0)	Family	The members of this family are sequences derived from hypothetical eukaryotic and bacterial proteins. The  region in question is approximately 60 residues long.	23.50	23.50	23.50	25.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.51	0.72	-3.75	75	599	2009-01-15 18:05:59	2004-09-09 14:35:58	7	4	563	1	312	536	163	65.50	37	65.31	CHANGED	Eu-pp+tt...tt.................................P.....tElG...G.scG.EPsRY......GDWEpcGRssDF	......................................................................tttt..t.......................................tpstP........tElG...G.s.cG.....EP.s..RY......GDWEhKGRssDF..........	0	89	167	248
+7728	PF07897	DUF1675		Protein of unknown function (DUF1675)	Fenech M	anon	Pfam-B_4280 (release 14.0)	Family	The members of this family are sequences derived from hypothetical plant proteins of unknown function. One member of this family (Swiss:Q9SFV5) is annotated as  a putative RNA-binding protein, but no evidence was found to support this.	20.50	20.50	20.60	20.50	19.60	20.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.09	0.70	-4.54	6	138	2009-01-15 18:05:59	2004-09-09 14:43:05	6	7	27	0	84	134	0	171.40	27	53.82	CHANGED	EIELsLGLSLGGpFGsD....h++s.+LsRSSSlssssshscs.....puushts.ph............sL.RToSLPsEoEEEh+KR+EhQoL+RhEAKR+RsE+...hsusts..............stush.pRccpsusshspssspsstuustssoSSuhsEhssts.stt.spstt.push..h.h.spts.tts..Pssspsppsspspsspcstcs.p.cpsust-sspshhpDMPCVoT+GDGPNGK+V-GFLY+Y.tptEEVRIlCVCHGoFLSPAEFVKHAGGscVs........+PLRHIV	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.phP.hV.ops...Ps....G+plpGhhY+Y..pt.ppVpIVCsCHGsahoPsEFVcHAGu....ps...........................................................................	2	10	49	71
+7729	PF07898	DUF1676		Protein of unknown function (DUF1676)	Fenech M	anon	Pfam-B_4779 (release 14.0)	Family	This family contains sequences derived from proteins of unknown function expressed by Drosophila melanogaster and Anopheles gambiae.	24.30	24.30	24.50	24.30	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.33	0.72	-3.74	64	512	2009-01-15 18:05:59	2004-09-09 14:45:18	8	6	30	0	390	577	0	109.70	18	36.55	CHANGED	+hlphlschh....pp...........sp.lplssGlplV+ssst....sttspstphtpt.....................hsphlhc+ltpalpoHsLplphsp.ttpt.h.............................t.htEuR.................t+Kh++....hhhPhlh	.................................hhphhschh....pp...........sp..lpls..culpll+ssss.....tttspshp.ptt.................................t.hsphlhc+ltpalpoHslplp.lsptttpttt.............................tshtEuR.......................h+Khc+.......hhhPhlh..............................................	0	103	147	331
+7730	PF07899	Frigida		Frigida-like protein	Fenech M	anon	Pfam-B_4728 (release 14.0)	Family	This family is composed of plant proteins that are similar to FRIGIDA protein expressed by Arabidopsis thaliana (Swiss:Q9FDW0). This protein is probably nuclear and is required for the regulation of flowering time in the late-flowering phenotype. It is known to increase RNA levels of flowering locus C. Allelic variation at the FRIGIDA locus is a major determinant of natural variation in flowering time [1].	21.30	21.30	21.50	21.90	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.69	0.70	-5.65	22	700	2009-01-15 18:05:59	2004-09-09 14:49:35	6	7	74	0	143	485	0	188.80	38	53.50	CHANGED	sspsssspsssts.......pLppLCtpMDucGLhpFl.pphcphs..slppElssAL+tusDPApLVL-ulpsha.sspts...tpphphhshcpsCllLLEsLh.............hps.lss.......sl+-cA+plAhcWKspl.....sspsspsh-uhuFLpLLusFulsupFcp--lhcLlhhsut++Q...sscLspuLGLs.-+h.............................................................................................................sshIcpLlspGcplcAlph...hathsLs-pFsPlslLKsaLpc.s+csst.hhptss.......................s...putspstc+-lsAL+uVlKClE-p+L-tcas.-s..Lpccl.tpLcctctp+++sspssp	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hstlhh...h.......h...............................................................................................................IVE.hlppGhpIEAlph...sasFGh.DKFs...sss.lLpuaL+..uKcs.pth.....................................................................................t.p...h..h.phhpt.p........................................ts...........................................................	0	11	76	106
+7731	PF07900	DUF1670		Protein of unknown function (DUF1670)	Fenech M	anon	Pfam-B_9559 (release 14.0)	Family	The hypothetical eukaryotic proteins found in this family are of unknown function.	25.00	25.00	25.00	26.20	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.33	0.70	-5.12	6	52	2012-10-04 14:01:12	2004-09-09 14:52:00	6	3	10	0	21	55	62	189.40	31	74.16	CHANGED	lhs-apFhsG..Vs+hlscplhphhcp.a..ssplcsGQllahulSs-Ess..GKslp-ppLlsVhLTLls.EDh-shpc.hthsElhcp+llRlspEAa-QsALLTpsDlAhLLshSpsTIS+clcpYcpc.GcllPTRGhl+DIGsuloHKphIlcLYLKGhpToEIARpTpHS.Eul-RYIKDasRVphLhpKGhss-EIphhsGlScplVcEYhEL	.....................................h..h.p.h.pthhphhpp..a.....pphp.GQhhahslstppss..GKshpphphhslhLolhs..-D.c.....hppth.t.pphpppplhRlhpEAacQsuhLTptDlA.hlLshSspTlp+plcphpcc.s.llPsRGph+.DlG.suloHKphl.lch.alc.s.hphs-IuRpTpHS.pAlpRYlpsFp+Vhhh.hpcshpspElthlsshoppLlp-Y.t..............................	0	16	19	19
+7732	PF07901	DUF1672		Protein of unknown function (DUF1672)	Fenech M	anon	Pfam-B_9698 (release 14.0)	Family	This family is composed of hypothetical bacterial proteins of unknown function.	25.00	25.00	25.20	25.30	22.60	24.90	hmmbuild  --amino -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.92	0.70	-5.41	7	690	2009-01-15 18:05:59	2004-09-09 14:53:00	6	1	200	0	7	359	0	239.30	62	91.09	CHANGED	ETKSVPEEM-ASKYVGQGFQPPAEKDAIEFAKKH+-chtKhGEQFFhDNFGLKVKATNVVGSGDGVEVaVHCDDHDIVFNASIPFDKshIcp-uShRSpDpGDDMSshVGTVLSGFEYRAQKEKYDNLhKFFK-NEcKYQYTGFTKEAIsKTQNsGYpNEYFYIos.shsLpEYRKYaEPLI+KsDcpFKcGMcpu+Kplshpups-lsTTLFSTKcNFTKcssh--lIchS-cl++h+phPcshplolQlucspINTp+s.YssppslEhtVapp....E	..................ETKSVPEEMEASKYVGQGFQ..PPA...EKDAIEFAKKH+.cchtKhGEQFFhDNFGLKVKATNVVGpsDGVEVaVHC-.DHsIVF.NASlP....h.KshI......cpcu..ShR..S..pDpGDDMShhVGTVLSGFEYRAQKEKYDNLYKFhK-NEcKYQYTGFTKEAINKTQNsGYpNEYFYITh.s.hsLpE.YRKYaEPLI+KsDcpF+cGMppu.+Kpls.hpu.ps.pssoTLFSppcNaoKcppl-s.VI-hS-plcch+.shPp.p.plolQlupphIsT.p+s.YscppslchtV......................................................................................	0	4	4	7
+7733	PF07902	Gp58		gp58-like protein	Fenech M	anon	Pfam-B_4289 (release 14.0)	Family	Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58 (Swiss:Q38355), a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H [1].	30.00	30.00	30.10	30.10	29.70	29.80	hmmbuild  -o /dev/null HMM SEED	601	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.77	0.70	-6.30	10	178	2009-01-15 18:05:59	2004-09-09 14:56:42	6	11	111	0	20	176	0	345.80	24	41.91	CHANGED	MSRDPTLTlDE.......SNLoIGuDGRsYYTFTA-sDspoV+LAsN.ClGTTRFNQLMIERGsKsTsYVAPVVVEGoGpsTGLFKs.......LKElNLELTDTcNSpLWuKIKLTNpGMLpEYacssIKoEIlpoAcGItpRIS-DT-+KL............................................ALIN-oIsGIRR-YQDADRcLS....uSYQAGI-GLK........ATMANDKlGLpAEIpsoAQ....GLSQ+YDsEl+pLSAKI....TTTSSGTTEAYESKLsGLRAEFTRSNQGMRsELE.........................ScISG..LpusQQoTApQISQEI+NRpGAVSRVQQsLDSYQRRLQsAE......cNYSSLTQTVpGLQScVSuPssplpSRhTQLts.I-Q+VTRscVpSlIspSGDSIhLAI.Kuth.pSKMSusEIISAINLNuYG.V+IuGcpIALDGNTTVNGAF..uAKIGEhIKL+ADQIIuGTIDAsKIpVINLNASSIV.......GLDAN.......FIKA+ItYAITuL......LEGKVIKARNGAMhIDLsSuphsFNpsApINFNos-NALhRpD.uTpTtFl+FoNussh....uapGus.YAthsIoS......suDGl-sssSGpFuGlRhaRhAouYppTusVDpsEIYGDsVlItcshNhshGaphp.s+sspllDhN.....h.A.u.hh..............hT	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................l.t........................................h..t.....t..th.....o.......lp.t....s...sp.....h.sl.........psthsus-llStINLss..tG...l.pIs...Gcp.ltls.GsThl..ss..sh............sutl.up..................lpAspIhsGolsAsclpshsl..sAspIs.....................tlsAs...............hhp.thh...t............................................................................................................................................................................................................................................................s.......................................................................................................	0	3	11	17
+7734	PF07903	PaRep2a		PaRep2a protein	Fenech M	anon	Pfam-B_4102 (release 14.0)	Family	This is a family of proteins expressed by the  crenarchaeon Pyrobaculum aerophilum. The members  are highly variable in length and level of conservation.  The presence of numerous frameshifts and internal stop  codons in multiple alignments are thought to indicate  that most family members are no longer functional [1].	25.00	25.00	32.90	32.80	21.10	19.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.68	0.71	-4.46	8	34	2009-01-15 18:05:59	2004-09-09 14:58:44	6	1	1	0	34	34	0	80.20	53	72.37	CHANGED	hsAlspWYhpCFGcs...Gp.tKVVKRLEEYauMCQMtpAsKREaG.+.splhhSEaALRRAFWW-GEWpGKPhSCFVTE+cAVCKVGcpphcFhVhssscGVYl+PEh.Lhp-WIKVAHRGsD	...................................................htEhG......h..-huL+tuF..ctt.hstshSCFVTE++AlCKVG-+hAsFYVFDTPcGVYL+PEIKLlp-WIKVAaRGs.......	0	34	34	34
+7735	PF07904	Eaf7	CT20;	Chromatin modification-related protein EAF7	Wood V, Bateman A	anon	Wood V	Family	The S. cerevisiae member of this family Swiss:P53911 is part of NuA4, the only essential histone acetyltransferase complex in Saccharomyces cerevisiae involved in global histone acetylation [1].	20.80	20.80	22.00	22.00	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.27	0.72	-4.01	19	246	2009-01-15 18:05:59	2004-09-09 15:29:00	8	3	222	0	178	256	0	90.30	31	35.27	CHANGED	EpEhpLF+ultp.aKPV...Glp+HFtMhsIh-clspt..............hscphsupslWcKLsphYsLctLD-hE.....pshshsscpc..........................-FsLPps-auc	..........................EhpLhcuhht.a+Ps............Ghp+HFpMlsIt-+hppp.........................................hscphsscsIWc+LsohYsLptL--pE...............h..shssppc..............................................................pFsLPpp.ht.t.............................................................................	0	52	92	145
+7736	PF07905	PucR		Purine catabolism regulatory protein-like family	Fenech M	anon	Pfam-B_4388 (release 14.0)	Family	The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, Swiss:O32138). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain.  It is similar to LysR-type regulators in that it represses its own expression [1]. The other members of this family are also annotated as being putative regulatory proteins.	28.90	28.90	28.90	29.80	27.20	28.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.22	0.71	-4.54	113	1282	2009-09-13 12:56:03	2004-09-09 15:29:15	6	5	619	0	359	1123	18	122.10	25	24.49	CHANGED	p-lLphsslpts..plluGp.....psLc+slcWVpls...Ehs.Dhssa..........LpGGELlLTTGhsltp.ssp...hppa...lcpLscsusuu..Lslths.hhp.p.lP..psllphAcphslPllplst...plsFsslsptltptlh	................................-lLphstLptt...pllu...Gc.....ps.L.s.p.s.Vphlplh...Ess...Dh...s.sa..........lpuGEL.lLToGhshpc.stp...........hppa...lcpLtp.tss..uuLslph.s.t.hht..plP...ppll...phAsphslPllplPt....shsasplhptlhp.h.....................	0	152	276	325
+7737	PF07906	Toxin_15		ShET2 enterotoxin, N-terminal region	Fenech M	anon	Pfam-B_4512 (release 14.0)	Family	The members of this family are are sequences that are similar to the N-terminal half of the ShET2 enterotoxin produced by Shigella flexneri (Swiss:Q47635) and Escherichia coli (Swiss:Q47634). This protein was found to confer toxigenicity in the Ussing chamber, and the N-terminal region was found to be important for the protein's enterotoxic effect. It is thought to be a hydrophobic protein that forms inclusion bodies within the bacterial cell, and may be secreted by the Mxi system [1]. Most members of this family are annotated as putative enterotoxins, but one member (Swiss:Q8X606) is a regulator of acetyl CoA synthetase, and another two members (Swiss:P76205 and Swiss:P23325) are annotated as ankyrin-like regulatory proteins and contain Ank repeats (Pfam:PF00023).	25.00	25.00	29.70	29.40	23.50	20.10	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.92	0.70	-4.94	8	670	2009-01-15 18:05:59	2004-09-09 15:30:05	8	1	306	0	7	369	0	250.50	38	50.79	CHANGED	o...hph........pphlppcphosps.pchlptcpK..PYhSc.KppsplNLNGps..s-psuchIhCRHLAuQYhhDhh..pssGKVsh.ccaSSs-pIpp+lslpcccphpsl..p.PuslYalsNscFGpslsshFppMcppucsspolhlposNHuMAlRL+IKcoppGp.+.aVVshYDPNtTssplRs...ssstsclpphSlccFls....ppthpsYu.pcsspphhs.psphPcppslh..t.......scls.sPLsssslhhhMstGhsctIpplhcplchhscpc..sphhplLsA+s	..............................h.....h...........pp.hs.......hp.spK......c.p..spl.pLNGpshF...s..tpP..p...stIhCRHluhQYh.D.h..pspG+lsh.ccYSSsEp..ltpHlshppcp.....ph.....hsLhpp.PtGppVlAstDFGhslphaFs+MpsNs....lShMuAILhssN.............HshuVRLRIKp..ospGphc.YVVSlYDPNsTNsplRh...spsppshthhSL.cFhs...ss.sh.pWuscplh..spsluIl..PhLPcpp.lhlhssh.......schs.sPlpPush.LlMuhG.spplhplh.plph....hschc....hhphlsAhN....................	0	2	5	6
+7738	PF07907	YibE_F		YibE/F-like protein	Fenech M	anon	Pfam-B_4781 (release 14.0)	Family	The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE (Swiss:Q9CHC5) and YibF (Swiss:Q9CHC4). Most of the members of this family are annotated as being putative  membrane proteins, and in fact the sequences contain  a high proportion of hydrophobic residues.	27.20	27.20	28.10	28.10	26.00	25.90	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.36	0.70	-5.19	89	1478	2009-01-15 18:05:59	2004-09-09 15:37:41	6	2	897	0	279	1002	29	239.00	28	70.23	CHANGED	ss.lhhlshlahhlllllGtppGlpul.luLhlshhllhhhl.lshhhtGhsslllsllhshlhhhloLhllsGhsp+ohsAhluTlhulhlshllshhhhphsplsGhs.EpsphLthhstt...lph.tlhhuullIuuLGAlhDluhoIuSulhElhppsP....ploh+pLhpSGhslG+DlhGThsNTLlhAahGuulshlllah..thshshspllNtchhuhEllpslsGuIGllLslPlTshl.suhh	...............lhllshlhlhlllllGtcpG.ltul.loLhlNhhllhhhl...l.hh.tGhshhllshlhsllhshlsLhllsGh.sh.+Th.sAhluTllush.lshhlshlhhthsphpG...hs..h...Ep...h...p.....lth...hshs....lph..tlhluslllusLGAlhDluloIuSulaElhpps.P....ploh+cLhpS.G.hplG+-lhGThsNTLlhuahGusLs..h..hlh.ah..p...sh..ohsphls.p.huhEllpslhGuIGllLolPlTshlsuh.h.............	0	119	208	254
+7739	PF07908	D-aminoacyl_C		D-aminoacylase, C-terminal region	Fenech M	anon	Pfam-B_13711 (release 14.0)	Family	D-aminoacylase (Swiss:Q9AGH8, EC:3.5.1.81) hydrolyses a wide variety  of N-acyl derivatives of neutral D-amino acids, in a zinc-dependent  manner. The enzyme is composed of a small beta-barrel domain and a  larger catalytic alpha/beta-barrel. The C-terminal region featured  in this family forms part of the beta-barrel domain, together with  a short N-terminal segment. The beta-strands of both barrels were  found to superimpose well. The small beta-barrel domain does not  seem to contribute to the substrate-binding site or to be involved  in the catalytic process [1].	22.40	22.40	22.40	22.40	22.30	22.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.14	0.72	-4.65	150	859	2009-09-11 00:09:33	2004-09-14 13:31:24	7	23	530	12	324	878	733	47.40	33	9.08	CHANGED	Ppp.lpDtuoas..cPhphAsGlctVlVNGtlsh.c.......sGp....sTG......spsG+llRps	........stp.ltDhuoa...p...cPpphupGIctVhVNGthsh.c..........cGp....hTu......spsG+hl+t.t............	0	114	222	284
+7740	PF07909	DUF1663		Protein of unknown function (DUF1663)	Fenech M	anon	Pfam-B_4106 (release 14.0)	Family	The members of this family are hypothetical proteins expressed by Trypanosoma cruzi, a  eukaryotic parasite that causes Chagas' disease in humans. This region is found as multiple copies per protein.	25.00	25.00	53.80	51.70	18.00	17.40	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.87	0.70	-5.97	2	85	2009-01-15 18:05:59	2004-09-14 13:33:30	6	9	6	0	4	85	0	202.10	76	97.85	CHANGED	htlpRcAVspcE......................RusRchlEtucAAh.DE..............LG.....-.hhssTHE+................uspshsAcEsttRGp.VGpE.............RcshsGhH...cpslcuEER...hsR+hLphtEstuhsplhp..........chR.hppp+t.phhtA.pDAths.httEER.......RshlsScE+hsRRhlEtG.hut.D...phGcEhusA......saphAlpthuhpEsAARtp.h.E.....YuhpRDul.Sp.psshpsLc+GpustVs..............ELhpEYcpsscchhsEtlhu..D........AsRtplVhEE.....sLH+ssl.oE....p+AVR+...............................slERsEttAhD.l..........................GEp.hSsshpR...........................slEsLttE	..........................................................................................................................................................................RcshhG.LH...RDAVDSEER...AVRRpLE+GEAAAVDELGE..........EYRSATHERsVEALAAEEDAARGQLVGEEREDshGLHRDAVDSEERAVRRCLERGEAAAVD....ELGE..EYtSA......THERsVEALAAEEDAARGQLVGEER............EDsaGLHRDAVDSEERAVRRCLERGEAAA..VD................E....LGEEYtSATHERsVEALAAEED........AsRsplVhEE.....................................................................................................................................................................	0	1	2	4
+7741	PF07910	Peptidase_C78	DUF1671; 	Peptidase family C78	Fenech M, Bateman A	anon	Pfam-B_9699 (release 14.0)	Family	This family formerly known as DUF1671 has been shown to be a cysteine peptidase called (Ufm1)-specific protease [1].	29.10	29.10	30.50	30.30	25.70	28.50	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.77	0.70	-5.22	38	453	2012-10-10 12:56:15	2004-09-14 13:38:51	8	18	236	3	315	461	3	187.60	30	42.79	CHANGED	upthhlhushshaHYtp.uhsDcGWGCuYRslQhllSWhht.......phh....s.....slPoIhcIQphL.chh.DK..ss........shhGo+cWIGosEsthllspL..slps+lhpht...............................................psu-l...sphhptltpaFp..sp.u....................sPlhltt..s........................shuhTIlGl-hp.......psuphphLlhDPHasus.ssh+hlhpcshsua...............+sssh..hp+...sphYpls	.............................s...hh.sshthhHa......hp..thsDp....G.....WGCu.........YRslQhlhSahh.t..........thh.................s........slP.ohhclQp..hl.psh.Dc..ss..........shhGo+pWIGohEst....hlLspl..sl......ps+llphp..................................................................................pssph...sphhc.lh........pa..Fp..st....s................................sPlhltt....s........................shu+TIlGlphp..................tss..p...hphLlhDPpasus...p.hp........hlhpp..shssh..........................+s..ssh..h.p...pt.Yplh.........................................	0	110	167	249
+7742	PF07911	DUF1677		Protein of unknown function (DUF1677)	Fenech M	anon	Pfam-B_4922 (release 14.0)	Family	The sequences found in this family are all derived from hypothetical plant proteins of unknown function. The region features a number of highly conserved cysteine residues.	25.00	25.00	27.30	26.80	23.00	22.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.33	0.72	-3.80	26	199	2009-01-15 18:05:59	2004-09-14 13:44:12	8	4	19	0	134	186	0	88.20	45	57.50	CHANGED	ElE.ss.+CECCGhpEECTspYItpVRscasG+WlCGLCuEAVp-Eht...R........psshslEEAlctHhuhCccFsuts...sPshp...lssuMRclLR+p	.......lEss+CECCGhpEECTstYIspVRs+atG+WlCGLCuEAV+-Eht...R.........ps.shshEEAlptHhuhCpcFps...s.....sP..slp...lspuMRplLR+p.............	0	12	72	108
+7743	PF07912	ERp29_N		ERp29, N-terminal domain	Fenech M	anon	Pfam-B_28781 (release 14.0)	Domain	ERp29 (Swiss:P52555) is a ubiquitously expressed endoplasmic reticulum protein, and is involved in  the processes of protein maturation and protein  secretion in this organelle [1,2]. The protein exists as a homodimer, with each monomer being  composed of two domains. The N-terminal domain  featured in this family is organised into a  thioredoxin-like fold that resembles the a domain  of human protein disulphide isomerase (PDI) [2].  However, this domain lacks the C-X-X-C motif  required for the redox function of PDI; it is  therefore thought that ERp29's function is similar  to the chaperone function of PDI [2]. The N-terminal domain is exclusively responsible for the homodimerisation of the protein, without covalent linkages or additional contacts with other domains [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.50	0.71	-4.20	3	92	2012-10-03 14:45:55	2004-09-14 13:52:51	8	4	73	13	52	132	2	117.60	51	47.87	CHANGED	lTs+GCVDLDolTF-KVlcKF+YSLVKFDTAYPYGEKHEAFTuLAhEssuoT-ELLlApVGIKDYGEp-Nt-LG-RYKlDKEsYPVIaLF+.GDu-sPVpa.PucG-VTlDuL++FLKupTuLYIGhP	........................................................spGslsLDploF.Kl.I.sK..Ka.l.LVKFDstYP.Y.G.EK..p...D...E..Fp...+lA.E.susuoc.DLLVAEV......GIp.D.YG-K..N.h-LuE+YKl-K-.saPVh.h.LFp.Gs...h-sPl.a.....sGslps.sslp+alKup..u..lYlGhP.........................................	1	15	18	33
+7744	PF07913	DUF1678		Protein of unknown function (DUF1678)	Fenech M	anon	Pfam-B_4886 (release 14.0)	Family	This family is composed of uncharacterized proteins expressed by Methanopyrus kandleri, a hyperthermophilic archaebacterium. 	25.00	25.00	35.50	141.40	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.35	0.71	-4.76	5	16	2009-01-15 18:05:59	2004-09-14 14:21:22	6	1	1	0	16	16	0	197.30	70	97.59	CHANGED	ss.+htlP...PcDPVEplRsLRVLhEshRRGphPhLtsoYRoVNGpshGPYY.ARWR.sSRaERGRTLYLGKSENESVpFlE.WLVSLsRtEVLELARH......LMRNLRSVLKoLLscVSuLPYK+...ARRVLAR.............GL..ALAFD.....ARPuuSP+.IRDVLEELPDRLESFllRTLGGWPAaYSS+Lc+llRuRRuSp-t+R.............tcVPDs..plcRhK.Rc	....p....HlP..IPpDPVERIRALRVLREVaRRG+KPSLEVTYRTVsGSTCGPYYVARWRRDSRa+HGRTLYLGKPENESVpFVE.WLVSLDRpEVLELARH......LMRNLRSVLKTLLTEVSsLPYK+...ARRVLAR.............GL..ALsFD.....ARPSpSPR.IRDlLEELPDRLESFhlRTLGGWPAHYSS+LcKlIRuRR+SLDG+H..............ElPDVtLELERWKLR.+..........	0	16	16	16
+7745	PF07914	DUF1679		Protein of unknown function (DUF1679)	Fenech M	anon	Pfam-B_4694 (release 14.0)	Family	The region featured in this family is found in a number of  C. elegans proteins, in one case (Swiss:Q19034) as a repeat. In many of the family members, this region is associated with the CHK region described by SMART as being found in ZnF_C4 and HLH domain-containing kinases. In fact, one member of this family (Swiss:Q9GUC1) is annotated as being a member of the nuclear hormone receptor family, and contains regions typical of such proteins  (Interpro:IPR000536, Interpro:IPR008946, and Interpro:IPR001628).	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.44	0.70	-5.84	20	190	2012-10-02 22:05:25	2004-09-14 14:22:31	6	7	8	0	178	1879	311	303.80	22	85.78	CHANGED	Lh-suDGLLpTHVTWcDVpcslpcphsTcAchGcs+phssIuDhpGFMS+luLlEs-Ws...t.psscpLPcKFsLKIoSpLslhslschhc.pssssascEc....hcthpphs+chHNREVshYKlLpKhN.pssl.hsKVYhhKpF-...--NcLKGalhhEalsslcshpha-slss--Lhsll+uIAshpAhuhpLo...--Eppph.tGt-a.c.hhpphhs-cslcshacphRphh.s...sE+lcEhlchhcpYh.plh.hcphsplschlGh.+sVLsHGDLWsuNlLaspps-GphplctlIDaQslphusPA.DLsRLhlosLSspDRRp+hpclL-paY-sFlcsL..ts.ctPYohcpLc-SYpLYFPhhulhlLPhlushl-sp...shspcct-ph+chshcKhtuLhEDlhchHc.sh	.....................................................................................................................................................................................................................................................................................Gh..S...hhhlt.pa.........t..hPtphhlK................hs................t.....h..h.p...........h..t...........t.h...h........hHN...pEsthY.p.....h.h.t.php............th.......hs..+....................h...Y.....hh..pthp.......pt....t.....h...t...G...hl..hh.-..h..h..t..s..h.....h.....h.....t..h.....ht....sh...s........pp..l...h..l.................hcs.........luthpuh.u.h.......p...............t.c..p........h...p........h.....................t..h.........t........h...h......t..p.......h....h....t...................................h....p..t....h.....h.....t..................h........t............................................t....p.h.......t......p........h.....h..........p.h..h....t...h..................................................................h.....p..........h........p.....p.....h........p....p........h..h........G...............h......................V........l...sHuDlhtsNhla.......p.....p....t........p....p....................................p..l......t...........u...................l....I..D...........a................Qh................sp...hGsss.D....lh..+.l.h.h.........s....h..........o..s.p...............p..R+.....t.th..ptlL...c.a....a...p...t....h...h.p....h.........................................p.........s........a...o....h....p.....p..l......p......p.....t.......Y...p......h.....h....h..s...h....h....s.....h...h..h.........h...s...h.....h........h..h..................................................t..p....thht-h.........h...........................................................................................	0	85	98	178
+7746	PF07915	PRKCSH		Glucosidase II beta subunit-like protein	Fenech M	anon	Pfam-B_9407 (release 14.0)	Family	The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1]. Mutations in the gene coding for PRKCSH have been found to be involved in the development of autosomal dominant polycystic liver disease (ADPLD), but the precise role the protein has in the pathogenesis of this disease is unknown [2].  This family also includes an ER sensor for misfolded glycoproteins and is therefore likely to be a generic sugar binding domain.	21.80	21.80	21.80	21.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.14	0.72	-3.18	104	586	2012-10-02 14:19:21	2004-09-14 14:25:08	8	29	264	2	365	860	7	84.40	27	19.03	CHANGED	upChh...ht.su.......haoYchCah.....cplpQhc............................tctsspphhLGpa..................................t..t.p.p...............tp..ttt...a.............hshtassGs.hC	............Chh...tt..pu.......WWoYEaCaG........+clcQaHt.....................................spchptpphh..LGpa................................................................................ptt.ph.tpp.ssp..............................t.t.....tp.....tt.t..tha..................................hsphhssGohC...................................................................................................................................	0	128	189	295
+7747	PF07916	TraG_N		TraG-like protein, N-terminal region	Fenech M, Mistry J, Coggill P	anon	Pfam-B_4841 (release 14.0) & Pfam-B_689 (release 23.0)	Family	The bacterial sequences found in this family are similar to the N-terminal region of the TraG protein (Swiss:P33790).  This is a membrane-spanning protein, with three predicted transmembrane segments and two periplasmic regions [1]. TraG protein is known to be essential for DNA transfer in the process of conjugation, with the N-terminal portion being required for F pilus assembly [1,2]. The protein is thought to interact with the periplasmic domain of TraN (Swiss:P24082) to stabilise mating-cell interactions [2].	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.73	0.70	-6.05	62	860	2009-01-15 18:05:59	2004-09-14 15:13:40	6	7	549	0	140	792	47	399.90	21	55.85	CHANGED	Elash.hsG.hlpssl.ulhshoGhhs....hs.shlhls...hhlulhhtuhshshptsh..tph.phhhsshllhhh..hhsP......psslphp-pp...............................sshstpsssVPlhhAhhtulooslstuhspshpssh.s.......................h+hhptphptphh.sP..............tltpplpcFhppChhhshth..tp.p.pshh........ss...sc.hshls..................pupsPhpshhhssspsss....................sh.TCpphas......sL+scl.hspss...........shhhhspthhsth.tsttt...shlpshl.spshphhht.u.pshsshhppshhhsshpsuhsp.....t...........husstuhtptshshtsttphstpsLPhhpshlhhhhhshhPlllhluh..h...hshuhshhthahhshha.LutWhshhhllshhsthhht..................sttshshh.shhshstsp.thshlhGhhhlslP.hhstslshuGspshuslss.hhususssuppu	...............................................................phahh.h.u.hlppsh.ul.hhhhuhhs.............hs..shhhhs...hh.l.tsh.h...uh.........s.ptsh..............h.h.th...hhsh...h...ll.hhh...hhhs.......hsslpl.st...................................sshs.ttsspVPlhhuh.hulsstl.stuhstshtphh..s.........................................hp.hp.h..ph...p....hhhh..ss...................tltpphtsahppChhhshhh....tp.t..pphh.........ss........s.hshlh.................................................................pp.psh.pth..sss......................................sh.oCpphhs.............tL+stl...tphp........................thhhhhp.thhsh...h...s.........................shhhth...h..s.pshph...........u..........tshpphhtps.hhssh.tp.uhsp.........................hssst..u.htttphsh..hshhphhhphl....Phh.shlphhhhhhhPllhhhuh.....h....phshthhthahhshha.lthW...hhlhshhhph.h.t.........................stsshsh........th.p.t..t.......ht.s...hGhh....hh...hlP.hhshh...hsh.u...u.htsh..sshhs...hhsss.tsst.............................................................................................................................................................................................	0	28	72	112
+7749	PF07918	CAP160		CAP160 repeat	Fenech M	anon	Pfam-B_9359 (release 14.0)	Repeat	This region featured in this family is repeated in spinach cold acclimation protein CAP160 (Swiss:O50054) CAP160 is induced during periods of drought stress; its precise function is unknown but it has been implicated in the stabilisation of membranes, cytoskeletal elements, and ribosomes. By acting as a compatible solute, it may reduce the toxic effects of cellular solutes that accumulate at high concentration during dehydration; it may also function as an enzyme that produces such a solute [1]. Other members of this family are also induced by water stress, abscisic acid, and/or low temperature, such as desiccation-responsive protein 29B (Swiss:Q04980) and CDet11-24 protein (Swiss:O23764).	25.00	25.00	28.80	28.10	18.40	23.30	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.79	0.72	-6.76	0.72	-4.32	7	30	2009-01-15 18:05:59	2004-09-16 15:00:16	6	3	9	0	15	40	0	26.40	67	7.17	CHANGED	ISsAsuslADKAsuAKNsVASKLGYGs	..ISSATSAIsDKAluAKNsVASKLGYGs.	0	2	11	12
+7750	PF07919	Gryzun	DUF1683;	Gryzun, putative trafficking through Golgi	Fenech M, Pollington J	anon	Pfam-B_9179 (release 14.0)	Family	The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun (Swiss:Q7Z392) blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex.	26.20	26.20	26.30	27.10	26.00	26.10	hmmbuild  -o /dev/null HMM SEED	554	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.70	0.70	-6.19	51	282	2012-10-04 00:47:01	2004-09-16 15:05:11	7	8	231	0	202	293	2	497.10	19	45.31	CHANGED	lplch.cchhsh..............................lpsshsFpps.phpsspshphplslpSss...ssPlclsplpltFssphpshhhptsp............................................th.s.tsltLhPspsphhshthhscp.....uGchclsulphplt.......................ppthphshshpsp..stttshhhhptppsst..phhlt......................tpstsplhsp...........................sPplplph................shpsshhssEhhsls........lpIpNpcctstpsshththh.........................s...t..sttsps.h.....t..pt.tt.hphslu.lptusptshplhlp..........shpssphtLplphhYpl...............................sssspsslhpsts...................hplshhpPF.phsa.....chhs+h+spsh..................s.............hhhpppahLpsphhshu..........sLhl.ph...............................slplhstssshhs.htppt......................psstlpspp.tt.ph..................................................................................................................................................................thtph.hsscpsssh.sslpIpW+R......................sps....ts.....shssoslslPcl..l.ss.hplhsph......sspstlss.lplchplcN.sotphhshplsh................-sScs..FhFSGs+......phslp.llP.....hSc+plpasLhshps.............Ghh..........................hlP.plplhs	...............................................................................................................................................................................................................h..lt..tph.sh.......................lpsphhFpp...phpsspshphplhlpups........stslphsplplthss..t.......s.hh.hpt..........................................................sttshpl.ssp.hth..hphth.scp.....stchchsslpl.lt........................ppthphhhshp....t..ttttt..hhpttps.t..ph.hh.................................tt.hh..lhsp.....................................splplph.......................................tht.s.hhssEhhsls........lplpspc.ct..hps.hh.hhhh..........................................t..s.tspsh.............s.tp....t...hths..lupltsspphphh.lhlp............s.pssph.l...lphtY.l..................................tpp..s.h.h.psts.........................hplthh..PF...t............chh.phhsp.h............................................................hhhp.....ahLhsphhshu...............................sL.l.s..........................................plplh.st.s....shtp..tp.s.................................thhltstp.tttth...................................................................................................................................................p.shtst.ps.ssh.sphhlpW+R..............................ss.ts.........................hsposlslPcl..l.......t..hpl.sph...........ss.shl....tts.....htlphplpN..oshh.shpl.s.h................................-sS-s......FhFSG.K...................................p.hslp.llP.....hocpphhapl...hPhhs..........................Gh............................hP.plpl..........................................................................	0	66	109	164
+7751	PF07920	DUF1684		Protein of unknown function (DUF1684)	Fenech M	anon	Pfam-B_9328 (release 14.0)	Family	The sequences featured in this family are found in hypothetical archaeal and bacterial proteins  of unknown function. The region in question is approximately 200 amino acids long.	25.00	25.00	26.20	25.90	24.70	19.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.98	0.71	-4.34	59	312	2009-01-15 18:05:59	2004-09-16 15:12:52	6	2	229	4	161	351	127	142.30	35	56.67	CHANGED	h.psFpGLsaashDssaplpA...paps.........hsss.....................cshthtoss..GtttphhphGplpFpl....sG.pphpLpsap........thsstLFlsFsDtTsGp..poYuuGRYLphphsssp.u.........p.....lsLDFNpAYNP.CAYsstaoCPlPPtpNcLslslpAGEKp	..........ppFpGlshashDspaplpA...paps.........h.s.ss.....................cslslssss..Gt.ppph..tsGplpFph.......sG..pphpLpsht..........ttsssLalsFsDtToGp....poYuuG....RaLphshsssp.G................plslDFN+AaNPsCAaos.thsCPlPPspNpLslsVpAGEK......	0	54	121	154
+7752	PF07921	Fibritin_C		Fibritin C-terminal region	Fenech M	anon	Pfam-B_31175 (release 14.0)	Family	This family features sequences bearing similarity to the C-terminal portion of the bacteriophage T4 protein fibritin (Swiss:P10104). This protein is responsible for attachment of long tail fibres to virus particle, and forms the 'whiskers' or fibres on the neck of the virion. The region seen in this family contains an N-terminal coiled-coil portion and the C-terminal globular foldon domain (residues 457-486), which is essential for fibritin trimerisation and folding [1]. This domain consists of a beta-hairpin; three such hairpins come together in a beta-propeller-like arrangement in the trimer, which is stabilised by hydrogen bonds, salt bridges and hydrophobic interactions [1].	20.40	20.40	20.40	21.10	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.75	0.72	-4.07	9	39	2009-01-15 18:05:59	2004-09-16 15:16:02	7	3	37	32	1	56	4	96.60	34	16.66	CHANGED	hsphspslpD.lpsclGsssSGlpusslphsstl.Gssssss.slpccGlppolKs.psslt..........................G.......hls-ssssG......phYhcccGtWsplssh	..................sthssslQs.lQs-IGNssoGlpGpllpLss.ltGsNssus.sV-c+GlpsolKs.psshs....................................G.......hls-sPpDG......phYsR+cGtWs.lss.................	0	0	1	1
+7753	PF07922	Glyco_transf_52		Glycosyltransferase family 52	Fenech M	anon	Pfam-B_2778 (release 14.0)	Family	This family features glycosyltransferases belonging to  glycosyltransferase family 52 [1], which have alpha-2,3- sialyltransferase (EC:4.2.99.4) and alpha-glucosyltransferase  (EC 2.4.1.-) activity. For example, beta-galactoside alpha-2,3- sialyltransferase expressed by Neisseria meningitidis (Swiss:P72097) is a member of this family and is involved in a step of lipooligosaccharide  biosynthesis requiring sialic acid transfer; these lipooligosaccharides  are thought to be important in the process of pathogenesis [2]. This family includes several bacterial lipooligosaccharide sialyltransferases similar to the Haemophilus ducreyi LST protein. Haemophilus ducreyi is the cause of the sexually transmitted disease chancroid and produces a lipooligosaccharide (LOS) containing a terminal sialyl N-acetyllactosamine trisaccharide [3].  	21.00	21.00	21.40	21.40	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.92	0.70	-5.36	16	318	2010-01-08 16:41:35	2004-09-16 15:19:39	6	3	241	4	28	224	7	254.60	24	82.76	CHANGED	ppphhhlhhsssts.chshhhcplppps.pshhhppsppp.ph......hhhhhlc.phhp..tchhcplahuN.splhhphhLsth....phhsh-DGhsNhpppshhhtpp.thh..............t++lhphhlsschsl.chhp.pKh+as.hKs...pcNhh....ppsphlslhp...pplpshpsss......slLlsQ...Plhp.D............ccEp....Ichhcsllpcashp....hhhPHPR-shchs..hhhlsscllhEsY.hcllph..hpthplhThFSosslshhspss.hclshl+sph	.................................................................................................................h.pph.hlhh..sps.s.K..phahp..plt..h..s.p..c..s...hh.tstphpphh.h........hhhhhK..plhp.........pphc.pla..hA.shch.hhphh.LSph..t.c....lp..TFDDGosN..l..ppsh.h..ht.pp...hht........................tp+lhp...hhhs.p.c..h.sls...chh...phspt+aola.s...hpNlh....cptphl...L.hc........t......t.lssppss.........hplLLup....P.h.p..s...................cccp.....lph.hpchlcp.hshc........hhhPHP...Rps...hchp..t.lhhl.s.sph....l..hE-hhhc.h..lcp.......hhphclashhSosthsh...shss..hcshtlps..................	0	5	9	16
+7754	PF07923	N1221		N1221-like protein	Fenech M	anon	Pfam-B_9309 (release 14.0)	Family	The sequences featured in this family are similar to a hypothetical protein product of ORF N1221 in the CPT1-SPC98 intergenic region of the yeast genome (Swiss:P53917). This encodes an acidic polypeptide with several possible transmembrane regions [1].	21.20	21.20	22.60	22.10	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.84	0.70	-5.57	26	320	2009-01-15 18:05:59	2004-09-16 15:25:12	8	8	225	0	215	308	0	276.60	28	32.65	CHANGED	pPshcFpYuDspshscElsEWFsYs..-hs.hhts...+ssF-ccap.a.............pWpctshtpc+sahtpllssLpp.s.thttR..hcsLpslhYluhGsaupss..............................ScspQlphh+pNshLLhphushtsLhplLsphhc.............pstsspssssshsths..........pp-ltllLTlhYlhlpssppp..pspsppphhlcshltsLtcP......sLhshLhchIs..+hRWssssshPl+......................pllLLlWKslLLtFGGpcpLccsKptlctthslp..........t.tpsppsshlTsSPLDYphFRp-Isu+YPsassP..pshl......Ph-h-N	.............................................................................................s.ssh-FpYsDss.shttEls.EhasYs....-h...phhhs....ppsFEppap.....t................................pW....chsp..pppcs.......ahh..pllc..tLc...s.s....stptR........hcshcsllYlspGs.au-ss..............................oc.sc.hphh+hNshLLhp..hGshsslh-lLpht.h.-.............................................pstssss..s.hchss.hs.....................................hscss-LpllLolh....Y.lhlEsh+pc..........tt.st.tth.hpshhtp..Ltps................................shshhLhshls..+a.p......s.puspaPh+......................+llLLLWKslL..hsh..G....G.hc.pLpphKtthcthhuls............................................t..pu.sss...sshsss.l-.p..................................t....................................................	1	55	96	163
+7755	PF07924	NuiA		Nuclease A inhibitor-like protein	Fenech M	anon	Pfam-B_43172 (release 14.0)	Domain	This family consists of protein sequences that are similar to the nuclease A inhibitor expressed by bacteria of the genus Anabaena ((NuiA, Swiss:Q44296). This sequence is organised to form an alpha-beta-alpha sandwich fold, which is similar to the PR-1-like fold.  NuiA interacts with nuclease A by means of residues located at one end of the molecule, including residues making up the loop between helices III and IV and the loop between strands C and D.  The mechanism of inhibition of nuclease A by NuiA is as yet incompletely understood [1].	20.50	20.50	20.70	38.60	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.38	0.71	-4.25	6	25	2009-01-15 18:05:59	2004-09-16 15:30:56	6	1	21	3	12	30	0	128.40	35	95.48	CHANGED	TpsspshLcpLcpAocGLLFMSEoDaPFpsFhW.sshhsloPEpVLptsscs.DssVpslslDsFFusATT.p-WasscEpsTlppFQpLl-TLKssLp-lpVYRlG-lplDVYIlGcsssGsLAGLpT+VVET	.....................pphhcpLcpAocGLLahSES-YPFElh..hW..tsttslo.spplhphsGhs.sssVcplslDpFFpsssspp-Was-tppsssp+FQpLlpsLKssL..schpVYRl.GplplDVYIlGcsssGslAGlpTKVlET........	0	4	9	12
+7756	PF07925	RdRP_5		Reovirus RNA-dependent RNA polymerase lambda 3	Fenech M	anon	Pfam-B_9372 (release 14.0)	Family	The sequences in this family are similar to the reoviral minor core protein lambda 3 (Swiss:P17378), which functions as a RNA-dependent RNA polymerase within the protein capsid.\	     It is organised into 3 domains. N- and C-terminal domains create a 'cage' that encloses a conserved central catalytic domain within a hollow centre; this catalytic domain is arranged to form 'fingers', 'palm' and 'thumb' subdomains.  Unlike other RNA polymerases, like HIV reverse transcriptase and T7 RNA polymerase, lambda 3 protein binds template and substrate with only localised rearrangements, and catalytic activity can occur with little structural change. However, the structure of the catalytic complex is similar to that of other polymerase catalytic complexes with known structure [1].	17.30	17.30	17.40	17.30	15.50	15.40	hmmbuild  -o /dev/null HMM SEED	1271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.26	0.70	-14.17	0.70	-7.18	3	118	2009-09-10 15:58:44	2004-09-16 15:38:12	6	1	33	6	1	75	0	466.00	63	99.55	CHANGED	LFNALPspLQpLSLALSGppPLTD+IFEsAAcAWHVpPRSpsYKLLDHIPFSosVV..IPPSIYsuhsWScYaAlssspVlRVsThsuPDDVYVPNSsIuPLLoPL+TIP-YGpLHPAIENDAo-hGsspARhASTFaKIASSQARQVKlDPpRFLtFLLVopAuPRVPSGVloDQPshhDPopSPALaAIWQIMQ+YKlsGsYYAPALVVsoGAlWWIPPPG+RNsVoVQaLLTDLINLAILAasTcLSPoLEhsGVplYL+AASSsSYAasLLchKSIFPsLSLHSMYRstEFGGKCPsIEWTEPRScYKF+WhGVTQLa-GLRPpoPSpDsKALElhcKYGLsDVu+lII+cR+sHPRHsaDSVRFVRDVMALTSGMYLVRsPTMSVLREYSQoP-IK-PIPPcsWTGPVGNlRYLpDospGPARHLYcTWhtAARQlAtDPpTHDPLsQAIMRoQYVTARGGSSAALKpALtsosVsLPDFcGosVK+SSKIYQAAQLA+luFppLIsAIhA-VTMGIRNQVQRRARSIMPLNVPQQsVSAPHTLVANYINKHMNLSTTSGSAVpDKVIPLlLYASTPPNTVINVDIKACDASITYsaFLSVICGAMHEGF-lGssutPFMGVPSSIVsDRRssuAPYuRPISGLQTMlQHLA+LYpAGFSY+VsDuFSSGNcFoFPTTTFPSGSTATSTEHTANNSTMMEaFLsVauPpHsKSuoLKRIlKDMTIQRNYVCQGDDGlLIIPcpuAuKISuEDlsELLELLcKYGctFGWsYDIDaSDTAEYLKLYALFGCRIPNlSRHPPVGKEYAuPpT-EIWPSLlDIlMGpFaNGVTDsLpWR-WLRFSWAFACauSRGua+shpGpSVu.AQYPhWSFVYhGLPPILLPGQTPFIaSsYMPsGDQGMFSILstWRDaLTu+AooshPPL+RsHPVWGLADVPSLLS-lGVYpGYaAAQlsRRPcPSP-sAss-SlEQhTuALS-YLhpDPsLKuRVlRGRssWERLosoauuslsSRVPSLFDVPsKWltAGRDA-KPsPSuVA-MhcoLpRAtR+Sp+SFSRLLELYL+VHV+LGEulPLAVDP-VPpVAGADPLNDDHWaKhTSLGPIsQSTRKYFupTLFVGKTVSGLDVEAVDATLLRL+ILGA-PEAapAhLsGIGMSDSEAHpIAG+ISLADAQlVQLARVVNLAVPSSWMSLDFDohI+HHuYshpPGIocsSTclR-RuuWlsuILRLLCAohAMTssGPVssuhVo-IDGGusALuGsLRsWMRDV	....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GltuscPISGhQsMhQaLuKLYpRGFpYpVsDsFSPGN.FTHhTTTFPSGSTATSTEHTANNSTMMEsFLTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVsSETI..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	1	1
+7757	PF07926	TPR_MLP1_2		TPR/MLP1/MLP2-like protein	Fenech M	anon	Pfam-B_9285 (release 14.0)	Family	The sequences featured in this family are similar to a region of human TPR protein (Swiss:P12270) and to yeast myosin-like proteins 1 (MLP1, Swiss:Q02455) and 2 (MLP2, Swiss:P40457). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores [1,2,3]. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments [1], and is implicated in nuclear protein import [2]. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex [2]. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity [4].	30.00	30.00	30.00	30.10	29.90	29.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.87	0.71	-4.41	29	251	2009-09-11 18:57:06	2004-09-16 15:44:10	7	8	210	0	170	250	3	131.80	28	6.62	CHANGED	hppphsplps-lpphppptpphpp...phpphppDlcpQschsppAQpp....YEpElhpHucs.sppLppl+pphpphppphspLcppscpspspL.................................................pppcpsWppp+ptlcpElsphppRh--LppQNpLLHsQlEsls	.................h.ppphsplpsElpchhpctpptts...ptpptppDlppQuclApcAQpc....YEpELhhHAps.sctLpth+pp.......hsp.......hp....pphppLcppspsAcspL.........................................................................................tppcto...WpEpcptLccElschppRp--Lp..pQNpLLHsQlEsl....................	0	52	89	138
+7758	PF07927	YcfA		YcfA-like protein	Fenech M	anon	Pfam-B_2914 (release 14.0)	Family	The viral, archaeal and bacterial proteins making up this family are similar to the YcfA protein expressed by E.  coli (Swiss:Q9F561). Most of these proteins are hypothetical proteins of unknown function.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.97	0.72	-4.05	255	2133	2012-10-01 21:18:35	2004-09-16 15:49:37	7	4	1365	1	556	1700	149	54.70	24	71.59	CHANGED	hc-lh+hLp.ph.G........a..thh..ct.p.GSHhtap+ssppt..........hsls...H..sppc.lthstl+...pl.l+.ps	..................p-lh+hLp.pt.G........ahhh...ct.p.GSH.h..pappssppt..............hslP....H..stpc.lptttl+......pIh+........................	0	167	380	484
+7759	PF07928	Vps54		Vps54-like protein	Fenech M, Finn RD	anon	Pfam-B_9294 (release 14.0)	Family	This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog  (Swiss:Q9JMK8), the human homolog (Swiss:Q86YF7), and  the mouse homolog (Swiss:Q8R3X1). In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex  that is involved in protein transport between Golgi, endosomal, and vacuolar compartments [1]. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs [1].	20.90	20.90	20.90	22.10	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.64	0.71	-4.03	17	311	2009-01-15 18:05:59	2004-09-16 15:52:26	7	10	251	4	226	328	4	128.50	38	12.82	CHANGED	cspsahlssssLhllphlp-YhphhsphPslss-hhspll-h..........................L+hFNSRssQLlLGAGAhcsuG.LKsITo+pLALuSQsLphllthlPhl+thhpth.......t..hhtpac+lppDappHpsEItsKLluIhs-Rh	.................................................t.tppahlss...oslhllchlt-Yhphh.s..slPs...h...ss-hhsplh-h..........................L.+hFNSRssQLlLGAGAhp...s.u.G.LKsIToKpL...............A.LuSpsLphlht.h....IPh.................lRphhctp....................s.p.p...........s..h..........h.tcFD+..lp+sYp-H.spIpsKLlsIMssh.h.................	0	79	126	185
+7760	PF07929	PRiA4_ORF3		Plasmid pRiA4b ORF-3-like protein	Fenech M	anon	Pfam-B_4929 (release 14.0)	Family	Members of this family are similar to the protein product of ORF-3 (Swiss:Q44206) found on plasmid  pRiA4 in the bacterium Agrobacterium rhizogenes.  This plasmid is responsible for tumourigenesis at  wound sites of plants infected by this bacterium, but the ORF-3 product does not seem to be involved in the pathogenetic process [1]. Other proteins found in this family are annotated as being putative TnpR resolvases (Swiss:Q9LCU7, Swiss:Q50439), but no  further evidence was found to back this. Moreover,  another member of this family is described as a probable  lexA repressor (Swiss:Q7UEI4) and in fact carries a LexA  DNA binding domain (Pfam:PF01726), but no references were  found to expand on this.	26.60	26.60	26.80	26.60	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.08	0.71	-4.87	18	780	2009-01-15 18:05:59	2004-09-17 17:08:24	6	17	653	2	251	715	156	155.20	21	60.93	CHANGED	ssplapL+lsLpsspPsIWRRltVPtsloLspLHpVlQssMGWpssHLHcFphs.sppYsh...........s....................s.s.ss.s..hspsphpLspllt..ttscshpYhYDFGDsWpHpIplE+hlsttsssphPh.ClsGptA.sPPEDsGGhsGYpchL-hlscPc+........cap-hhcWhGc.........F-sptFshccls	..................................................h.hpl.l...........t.s.l..aRc.l..lssshshtpLH.t.slptuh.s.a......p......s......s....Hhap.Fhhs......stpast....s.......................................................................................h...s....s......s.t.s........h.t..pps...pLsplh...........pttp...c..............hhYhYDFGDpWpaplp..................lp..c..........h........t.........p............t.........s.......t.......hsh..h..lput..s.......s...sP.p..s..s....................................................................................t............................................................	0	89	173	216
+7761	PF07930	DAP_B		D-aminopeptidase, domain B	Fenech M	anon	Pfam-B_29283 (release 14.0)	Domain	D-aminopeptidase (Swiss:Q9ZBA9) is a dimeric enzyme with each monomer being composed of three domains. Domain B is organised to form a beta barrel made up of eight antiparallel beta strands. It is connected  to domain A, the catalytic domain, by an eight-residue sequence, and also interacts with both domains A and C  via non-covalent bonds. Domain B probably functions in maintaining domain C in a good position to interact with domain A [1].	21.40	21.40	21.40	23.20	21.30	20.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.90	0.72	-4.25	2	66	2012-10-02 21:13:33	2004-09-17 17:09:08	7	2	65	1	6	26	0	87.40	75	17.05	CHANGED	sucssRspAssuWFGSWLssETGLVLSLEDAGtGRMKARFGTuPEhMDlsutNEApSuhTTlRRDG-hIcLsRtsENL+LuM+RlKGE	........PAKPVRAQANPGWFGSWLNPETGLVLSLEDAGGGRMKARFGTGPEIMDISGENEAQSSMTTLRRDGDMIHLARKDENLHLAMHRLKGE........	0	1	3	6
+7762	PF07931	CPT		Chloramphenicol phosphotransferase-like protein	Fenech M	anon	Pfam-B_29509 (release 14.0)	Domain	The members of this family are all similar to chloramphenicol  3-O phosphotransferase (CPT, Swiss:Q56148) expressed by Streptomyces venezuelae. Chloramphenicol (Cm) is a metabolite produced by this bacterium that can inhibit ribosomal peptidyl transferase activity and therefore protein production. By transferring a phosphate group  to the C-3 hydroxyl group of Cm, CPT inactivates this potentially  lethal metabolite [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.08	0.71	-4.64	7	191	2012-10-05 12:31:09	2004-09-17 17:09:32	7	3	165	6	65	615	54	167.20	29	83.68	CHANGED	uclIlLNGsSSuGKSolucslQslhssPWhphusDsah-t.h.schps...............sssGlcats.h...........tP.hchhhtuhhculsAhAcsGsslIlD....-lhhstch.h.-th.clLtshcVhhVGV+Csht.lhctREhtRGD.....RhsG.............huthQhchVHpss.YDlElDTotpsshECAttItpphp	.......................................................................plIlLNGsSSuGKoolA.psl.Q.s...h.h.s...p....s..a....h..p..l.ul...D...h...ahtt...h.s...s.pt.h.p...................ts..tGlp...h..hs......................ssh.hphh.htu..h..h.........cu..l..tu..h..hcsGhs..V..lsD......cV...hh..s..t....th....h.-th..c...hh..p.....u..h..p..V..h....hV..G...V...+..s.....s..-...ht..c..R..E.h..t...R...G..D...............R..h..sG...............h..st..t.p..t..c.h...s....H......t..s.s.....t..YD......h......c.l.DTot.....hssp-sAcpltpt..................................................................................................................	0	15	47	56
+7763	PF07932	DAP_C		D-aminopeptidase, domain C	Fenech M	anon	Pfam-B_29283 (release 14.0)	Domain	D-aminopeptidase (Swiss:Q9ZBA9) is a dimeric enzyme with each monomer being composed of three domains. Domain C is organised to form a beta barrel made up of eight antiparallel beta strands. It is connected to domain B by a short linker sequence, and interacts extensively with the domain A, the catalytic domain. The gamma loop of domain C forms part of the wall of the catalytic pocket; domain C is in fact thought to confer substrate and inhibitor specificity to the enzyme [1].	21.10	21.10	21.70	102.50	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.17	0.72	-3.86	5	78	2009-09-11 05:52:52	2004-09-17 17:10:48	7	3	77	1	15	36	1	96.80	72	18.63	CHANGED	c+sDIAGRY+ucELEA-hplsucGGulYGuFEGaLGpGPhEhM+slGcDVWhLuspRuMDAPAPG-WTLVFpRc-sGcVTGVTlGCWLAR+VsYsKs	...A.RQDIAGRYRSDELE.ADLLLVS...EGGAIYGAFEGFLGKSDMYPLYAAGPDVWLLPVQRSMDAPSPGEWKLVFHRDAAGRITGVTVGCWLARGVEYKR.L	0	2	8	13
+7764	PF07933	DUF1681		Protein of unknown function (DUF1681)	Fenech M	anon	Pfam-B_4989 (release 14.0)	Family	This family is composed of sequences derived from a  number of hypothetical eukaryotic proteins of unknown  function.	28.90	28.90	29.10	29.00	28.40	28.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.14	0.71	-4.67	23	357	2009-01-15 18:05:59	2004-09-17 17:14:00	9	8	219	1	230	343	4	159.60	47	61.76	CHANGED	saEplLhl.pscValY+IP..PpsSs+.GY+AuDW.sh-........p.hWTGRlRll.........................................scucps..pIpLEDssoG-LFA..........................psPhsphs..suVEsVhDSSRYFVlRlpss.sG....+pAalGlGFpDRu-AFDFNVALQDahKh.............scppsphspppp.................sppP..chDhuLKEGpTIpINlus	.....................hEplLhl.ps-VaVY.+IP..PR.so.s+.GY..RAu-W.pls..........p.hWoGRLRls.......................................................u..+..Gc....t..s....hI...+.........LED.p.....so........G...ELFA..........................p..s...Pl...cph......shuVEsVsDSSRYFVlRlpDs..s....G....R.+AFIGlGFs-Ru.DAFDFNVALQDHhKa...............................................lcpppph.tcptp......................................t.pttPplDhuhKEGpTIplsls.s.........................................	0	83	126	176
+7765	PF07934	OGG_N		8-oxoguanine DNA glycosylase, N-terminal domain	Fenech M	anon	Pfam-B_29151 (release 14.0)	Family	The presence of 8-oxoguanine residues in DNA can give rise  to G-C to T-A transversion mutations. This enzyme is found  in archaeal, bacterial and eukaryotic species, and is  specifically responsible for the process which leads to the  removal of 8-oxoguanine residues. It has DNA glycosylase  activity (EC:3.2.2.23) and DNA lyase activity (EC:4.2.99.18)  [1]. The region featured in this family is the N-terminal  domain, which is organised into a single copy of a TBP-like  fold. The domain contributes residues to the 8-oxoguanine binding pocket [2].	20.10	20.10	20.10	20.30	19.50	18.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.67	0.71	-4.13	95	767	2012-10-02 11:58:57	2004-09-17 17:15:28	7	13	710	31	324	723	56	113.40	26	34.56	CHANGED	tl.hsttp..hsLptsL..psGQsF+..Wc.......cp.pss.........ahsll........t.s.....cllpl+.p....ps.....................splhhphht.............................................................pcshpphlpcYFsLch..s................Lssla.pph.....spt........Ds..........hhp.........................pthpph..pGlRl.L+QDPaEsL	.............................................................tp....hplp.sh....tsGQsFR...Wp........................pt...pst...................t....ahslh....................t.s....................pllp.lp..p....ss...............................................sp..lhhpsht.......................................................................................................tpshtphlpcYFsLsh..c.......................Lsplh.pph..........spt........Ds................hhp......................................ps..h..p..th....tGlRl.LpQDsaEsL........................................................................................................	1	121	203	278
+7766	PF07935	SSV1_ORF_D-335		ORF D-335-like protein	Fenech M	anon	Pfam-B_4933 (release 14.0)	Family	The sequences featured in this family are similar to  a probable integrase (Swiss:P20214) expressed by the SSV1 virus of the archaebacterium Sulfolobus shibatae. This protein may be necessary for the integration of the virus into the host genome by a process of site-specific  recombination [1].	21.60	21.60	22.50	21.70	21.20	18.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.71	0.72	-4.24	13	65	2009-01-15 18:05:59	2004-09-17 17:16:16	6	2	27	0	16	65	0	67.10	42	47.79	CHANGED	+tY...paGDhhIRERKG+YYVYKLEp..NGcVKEpYVGPLsDVVEoYlKlK...GGltssP.shshs......GhEPGooss	.......phaphuchhlREhKG+YYVYhlEp.psGch+-pYVGPLscVVEpYlchh.....uGl..ss..sP....ps.s........shpPss...h......................................	0	7	7	16
+7767	PF07936	Defensin_4	BDS_I_II;	Potassium-channel blocking toxin	Fenech M	anon	Pfam-B_56105 (release 14.0)	Domain	This family features the antihypertensive and antiviral proteins BDS-I (Swiss:P11494) and BDS-II (Swiss:P59084) expressed by Anemonia sulcata. BDS-I is organised into a triple-stranded antiparallel beta-sheet, with an additional small antiparallel beta-sheet at the N-terminus [1]. Both peptides are known to specifically block the Kv3.4 potassium channel, and thus bring about a decrease in blood pressure [2]. Moreover, they inhibit the cytopathic effects of mouse hepatitis virus strain MHV-A59 on mouse liver cells, by an unknown mechanism [1].	20.60	20.60	23.10	43.00	18.10	16.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-7.95	0.72	-4.28	10	17	2012-10-01 20:50:19	2004-09-20 09:42:44	7	1	6	4	0	17	0	34.20	50	68.19	CHANGED	ssCpCuuKp..GsYWhs.husCPuG+GYTGsCtYhlG	ssChCGsph..GlYWas.hssCPuGaGYTGpCsaahG	0	0	0	0
+7768	PF07937	DUF1686		Protein of unknown function (DUF1686)	Fenech M	anon	Pfam-B_5313 (release 14.0)	Family	The members of this family are all hypothetical proteins of unknown function expressed by the eukaryotic parasite Encephalitozoon cuniculi GB-M1. The region in question is approximately 250 amino acids long.	25.00	25.00	37.70	36.90	21.30	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.44	0.71	-4.66	8	27	2009-09-11 08:48:26	2004-09-20 09:49:39	6	2	2	0	23	27	0	149.30	37	33.28	CHANGED	osstluWNTuLYSLAVAGsIsYQlWlLApp...hRccGsusMlRpsWoAlGCMsPMhsuL......hHuGlIRSusYSlTVAG.......luAVhlYVQsuspc..GMsh+QhCslsuGNllLuuAChuGssKh.hsuststsphlssGlVsFuulLLLVshsccutsGcKspu..pG..ltshlhVhohhVsshsS........hVCGRD	......tsthsWNTulYSlAVsGsIhaQhWlLstt....h.ptGh.thhpptWsslushsPMhsul.......psGhhpSshYuhshsG.......huhshhhsQshhpp..GMshpphCshssGN..llLushChuts.t.....s.thshhlshGhlVhsulLlll.hh..tttGccs.s......pG....h.phlhlhohhVsshsS........hVsuRs..........	0	23	23	23
+7769	PF07938	Fungal_lectin		Fungal fucose-specific lectin	Fenech M	anon	Pfam-B_48600 (release 14.0)	Domain	Lectins are involved in many recognition events at the molecular or cellular level. These fungal lectins, such as Aleuria aurantia lectin (AAL,  Swiss:P18891), specifically recognise fucosylated  glycans. AAL is a dimeric protein, with each monomer  being organised into a six-bladed beta-propeller fold and a small antiparallel two-stranded beta-sheet. The beta-propeller fold is important in fucose recognition; five binding pockets are found between the propeller blades. The small beta-sheet, on the other hand, is involved in the dimerisation process [1]. 	20.80	20.80	21.20	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.04	0.70	-5.14	3	66	2009-01-15 18:05:59	2004-09-20 09:51:25	7	5	46	25	47	63	1	208.30	21	64.82	CHANGED	AQEVLFRTGIAAVN....SsN+LRVYFQDlaGSIRESLY..EuuWANGTupNVIGKAKLGSPLAAT...SKELpNIRVYslscDNlLoEssYDG.sSGW.lsGuLuusslsVuPsS+luulahuGoso..PplRIYtQKSssusuTIpEYhWsGssWcsGoshGVolPGTGIGsTsaRYTDYsGPS.IRIWFQTDDLKLVQRAYDP+oGWY.pLsTIFDKAPPRsAIAATSFssGpSSIYMRIYFVNSDNTIWQV....CWDHGpGYHDsRTITPVIQGSEIAIISWGsh..pGPDL+LYFQNGTYVSAVS..EWsWspuHGSQLG+pALPPA	.....................................................s.............................p..........t.h.............t...........h.....................u...t.............oslAsh...............t..........la.h.t...tt.....htphh...t....ttW...Gt...h.t.....th...s..Stlssh...s..............hlhh.....s.......h...t........................t.....W......t.............h......s.......sss.huh..........sh..........p..s..s......p...lRlaa.pss..shpl..hptsa..-...sp.p...W......s.s.h..h.s.p.s.......s.t.ssluAs..sa....t..ss..hclahhstt..s.hhph.........hhpt.t..........................................................................................................................................	0	10	29	40
+7770	PF07939	DUF1685		Protein of unknown function (DUF1685)	Fenech M	anon	Pfam-B_5502 (release 14.0)	Family	The members of this family are hypothetical eukaryotic proteins of unknown function. The region in question is approximately 100 amino acid residues long.	20.30	20.30	20.80	20.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.25	0.72	-4.33	14	160	2009-01-15 18:05:59	2004-09-20 09:54:41	6	4	21	0	97	154	0	61.50	41	29.40	CHANGED	LTD-DL-ELKGCh-LGFGF..-E..t.s........scLCsTLPAL-LYaulspph.st.....ptSsssssssssuo	......lTD-DL-ELKGClDLGFGF...sc..p..s.............scLssTLPAL-Lhauhspph.s......................s.s...................................	0	14	60	76
+7771	PF07940	Hepar_II_III		Heparinase II/III-like protein	Fenech M	anon	Pfam-B_5577 (release 14.0)	Family	This family features sequences that are similar to  a region of the Flavobacterium heparinum proteins heparinase II (Swiss:Q46080) and heparinase III (Swiss:Q59289). The former is known to degrade heparin and heparan sulphate, whereas the latter predominantly degrades heparan sulphate. Both are secreted into the periplasmic space upon induction with heparin [1].	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.90	0.71	-4.34	158	1644	2009-01-15 18:05:59	2004-09-20 10:00:19	8	23	1018	12	395	1466	1366	143.20	18	21.37	CHANGED	psGathlps......sps.hllhc...sus.ss........ssHuHuDsLuF-lts.suptlllssGss...........tt............sch+ph.hR.uTsuHsTlsls.spsps..phht...................thhh.....................ththpt.........t.....shhhsst+suYht..........................hshtHpRplh.ls.........sptlhs.D.................pl	...........................sGhh.hhcs..........psh.hl.h.h..c...sGsh.s.......................ssHuHsDphuFp..lhh.pGp..lhhDsGths...........Ytp..................tphpth..h+..sotuHNTlh...ls....sps.pp..thst.......................shth...................................t.......................ttth.......thhh.s...s..hps.u.Ys.............................s.h.h.a.pRplh.ls......tphhhlhDp..............................................................................................................	0	167	309	348
+7772	PF07941	K_channel_TID		Potassium channel Kv1.4 tandem inactivation domain	Fenech M	anon	Pfam-B_7603 (release 14.0)	Family	This family features the tandem inactivation domain found at the N-terminus of the Kv1.4 potassium channel. It is composed of two subdomains. Inactivation domain 1 (ID1, residues 1-38) consists of a flexible N-terminus anchored at a 5-turn helix, and is thought to work by occluding the ion pathway, as is the case with a classical ball domain. Inactivation domain 2 (ID2, residues 40-50) is a 2.5 turn helix with a high proportion of hydrophobic residues that probably serves to attach ID1 to the cytoplasmic face of the channel. In this way, it can promote rapid access of ID1 to the receptor site in the open channel. ID1 and ID2 function together to being about fast inactivation of the Kv1.4 channel, which is important for the channel's role in short-term plasticity [1].	25.00	25.00	38.40	36.70	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.91	0.72	-3.75	2	44	2009-01-15 18:05:59	2004-09-20 10:06:49	6	2	32	2	20	45	0	72.40	77	11.62	CHANGED	MEVAMVSA-SSGCssHhPYGYA.QARARERER.AHSRAAAAAAsu.......GpGGs.GGGsthpt....ppts.ppp-	MEVAMVSAESSGCNSHMPYGYAAQARARERER....L....A.....HSRAAAAAAVAAATA.AVEGuGGu..GGG..u..HHHH...QoRGAsoSH-...............................	0	1	1	8
+7773	PF07942	N2227		N2227-like protein	Fenech M	anon	Pfam-B_5433 (release 14.0)	Family	This family features sequences that are similar to a region of hypothetical yeast gene product N2227 (Swiss:P53934). This is thought to be expressed during meiosis and may be involved in the defence response to stressful conditions [1].	20.10	20.10	20.10	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.79	0.70	-5.44	12	457	2012-10-10 17:06:42	2004-09-20 10:09:33	7	12	292	0	334	464	12	246.30	33	63.30	CHANGED	ss..hhsshhchsKlpssl+plsRDWSsEuptER-tsapPllppLsphhP.t.h-pppsplLVPGuGLGRLsa-luph..GatspGNEFSYaMLlsSpFlLNhspppspaplYPalHsaSNphspsDQLRslphPDhpshs.hs.......s.sshShsAGDFl-lYsps.......................psaDsVlTs..FFIDTAcNll-YlcTItplLKsGG..lWlNlGPLLYHFp................sh...ssphS.......lELoh--lhtlhpp.hGFpl.pccp.I.....cssYs..sN.cSMhpshYtssaass++ss	................................................tt.....s...chsKlpssl+phsRDWSs..-G..t.t...ERcss.apPllpp..........lp....phh..s............................t.....p............t................p...ph..p.....lLVPGuGLGRLsaEluth..........Ga.......t.s.p......GN.................EhSaaM..LlsSpal.L...N..t.........s.......p.............t................p.....papla..Pal.p.p.hS.Nphpp.psp.l+sl.thPDlpP.ts......hs.............................sshShsAGDFhp...l.Y.sp.p...................................................................ttaD...s..lsTs..FFIDT.Ap.NllcYlcsIhph...L..+.....s..........GG...........hWlNl..GPLLaHat................................................................s..........s.........................lELo.h--lhtlhpp.hGFph....t........pp...t...h......................ssYh....ts.pShhp....hYps.hassp+.t..............................................................................................................	0	128	204	285
+7774	PF07943	PBP5_C		Penicillin-binding protein 5, C-terminal domain	Fenech M	anon	Pfam-B_1086 (release 14.0)	Domain	Penicillin-binding protein 5 expressed by E. coli (Swiss:P04287) functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (Pfam:PF00768) is the catalytic domain.  The C-terminal domain featured in this family is organised into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides [1].	21.20	21.20	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.85	0.72	-3.97	74	4610	2009-01-15 18:05:59	2004-09-20 10:14:53	8	6	2602	30	731	2984	1285	93.00	27	23.36	CHANGED	F-shplhppsp.l...tphpVhtGpcc.....pltlsstcDl...hlsl.s.....+sptcplpsphph..ppslp......APlp+GphlGpl......ph.hhsschltp............h.sLlstpsVcc	..............................................Fcshphhptupth....sstpVh.h.G.cpc........plsl.s.s...pcsh...hlsl.P.......+..u..p..h...p.p...l......+.s.p.hsl.....pppLp...................APlp+GpsVGpl........ph..phc.s..c..p..ltp....................h.sLlshpsVtc.........................	1	223	436	575
+7775	PF07944	DUF1680		Putative glycosyl hydrolase of unknown function (DUF1680)	Fenech M	anon	Pfam-B_4918 (release 14.0)	Family	The members of this family are sequences derived from hypothetical bacterial and eukaryotic proteins of unknown function. One members of this family is annotated as a possible arabinosidase, but no references were found to back this. These proteins are related to a large family of glycosyl hydrolases.	24.90	24.90	24.90	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	520	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.74	0.70	-6.23	20	1388	2012-10-03 02:33:51	2004-09-20 10:18:10	7	35	764	0	436	1283	178	495.00	25	73.60	CHANGED	sV+lps.uhatpptcsspphll.....ltsD+........lhcshh............hpuhlsstt........shGsaE.........................h.uhshpssslG.....+aLpulAhhhAspsDspLcp+hcplls.tlucsQp.......sDGYLsuhhptt...........................shscsWss............hYsht+lhtGhlshYphoGppphLclsp+hADah....hsshus-phpchhhs...pHsthp..ulscLY..............phTG-p+YLcLA+hFhcpcshsP...................................hshspDclsshctsTtlu+sV.......GhAclaphoGDsshhp.......sucphWpslss++hYlsGGsusp....................EtFssshclsspssh...sETCuolshlhhsc+hhphs........s-.upYsDhhE+sLYNslLuuhs.Du..stahYhsPL...tsssp+.p..........hppcapuhhCCsssshcshsphucalYsps......cc..slaVNLahsSpschchpu...lpLcQcTs..aPapuplplTl.........psstssphsLtLRlPuW.................uuu...splplNGcs........sspttssuYlplsRcWpcGDplpLpLPMslchhtu....p-ssspVAlhpGPlVhs	.................................................................................................................................................................................................................lpl.t.s.shht.p.h.phshphhl......h..cp............h.ts...........................ps.......l...s.h..t..........s.h.s.....p.....................................s.h.h.p.spshs.......+alcuhu.h.h.s..t.....p.....s.........D.........s.............p.......L....c....p....p....h....c....phlp....hl.ttsQp..............sDG..Ylsshhphp............................................................s..p.ppWss..........................hYsht+hhp......u..h....lsha...p......h..T....G......p....p....p...........h....Ls....lsp+h.AD....al..............................ss.......h....us.t.p.....h....p.....h....h..h....hs................t+.s...t..........hp......u.....lhc....LY.....................ph..T...s..c.......t.......+.......Y.LpLA....p....hFhc.pp.sh.ps...........................................................................................................................................hthpps.c.lsh..h...c.t.p.....s...t.lu..+sV.......................Gh...uc...lh..ph.....o...s........D.....p..t.....hhp................sspphWp.s.hsp.+.chY.lTGGhuup.............................................EtF...s..s..s......h.p....l.s.sp..hsh..............sE.o.Cu..slshhh.hs...........cchhphp........s..-...upYADhhE+............sLYNsllu.u....h.............s..............-s..............t...ta.......hY..h...sPL...........pstspp....................................hppta...h.u.....h.s.CCss..Nhscshsph.s.p.h..l..Ys...p.................................ss......sla..lsl.Y.h.s.sp..hp....h.ph.......t......s..........l..p..lppp.os............YP...a...p...t.....p.......l.plsl............................p.s.s.p.s.s.p..a.sLtlRlPsW.....................spt....sp...lp.l.......N...Gpt.....................htts.hts.u..Ylpl.p.R.p..W.p.pG.D.p..l.plp.lP.M.t...l+hh..hs.......ps.tsplAlt+GPlVhs.................................................................	0	156	320	388
+7776	PF07945	Toxin_16		Janus-atracotoxin	Fenech M	anon	Pfam-B_50381 (release 14.0)	Domain	This family includes three peptides secreted by the  spider Hadronyche versuta (Swiss:P82226, Swiss:P82227, Swiss:P82228). These are insect-selective, excitatory neurotoxins that may function by antagonising muscle  acetylcholine receptors, or acetylcholine receptor  subtypes present in other invertebrate neurons [1]. Janus atracotoxin-Hv1c (J-ACTX-Hv1c, Swiss:P82228) is organised into a disulphide-rich globular core (residues 3-19) and a beta-hairpin (residues 20-34). There are  4 disulphide bridges, one of which is a vicinal disulphide bridge; this is known to be unimportant in the maintenance  of structure but critical for insecticidal activity [1].	25.00	25.00	84.30	84.20	19.90	16.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.25	0.72	-4.28	2	4	2012-10-01 22:06:18	2004-09-20 10:20:42	6	1	2	1	0	4	0	35.80	87	97.95	CHANGED	sICTGADRPCAACCPCCPGTSCpu.EsNGVSYCRpD	..sICTGADRPCAACCPCCPGTSCpGPEsNGVSYCRND.	0	0	0	0
+7777	PF07946	DUF1682		Protein of unknown function (DUF1682)	Fenech M	anon	Pfam-B_4955 (release 14.0)	Family	The members of this family are all hypothetical eukaryotic proteins of unknown function. One  member (Swiss:Q920S6) is described as being an adipocyte-specific protein, but no evidence of this was found.	23.80	23.80	23.80	25.00	21.50	23.70	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.96	0.70	-5.58	39	327	2009-01-15 18:05:59	2004-09-20 10:21:26	9	6	273	0	236	331	0	316.70	27	76.34	CHANGED	hpsahhEhh.slshlllhlhhahh..GpppNcphAppa...hpsppshhppp..FuhlGhstst...............................hlhccu.spashYATGRpssstlhlslcLhpRpshhshl.hphlhsh............pDphplpl.............................spsshDs............hlaAlVpKpshpph+c-ph.-L................Sh......spop-ptpLPpphslhoEusElsstlls.sp...........lhpsls.ps.sch...lcaltlTDQshtps.p.p.............cts...................................c+plhlshslPpsss.....ht..phttLlshhlphhDpls........shclps-shcKscpsRppthcchhKttcpt+tEt..htpc+tctK+pc+cphhsphosEcQ+Kh-.........cKcpc+pt++	.........................psahh.Ehh.hlshllhhhh.ahh..GpppNpphAptW...................hps..p....ps...lLppp..FuhVG.ssstp.........................................pshLhccstp.ash..asoGRpsspshhlplc..........hhpRpsh.lshl.hchhhsh............pDplplpl............................t.hspps.hDs..............aVaA..lspKcshpphp..c-...hh.DL.....................Sh.............spstsp.....t...LPsp....hslhSE..sElss.s..hls..sc............hhpslp..ph...uch..............lchlthoDQ.ss......p.....psp............................................s++plhhs.hs..lPssss..................hp.shhsLhphhhh.hhDplt.............ph+hs..t-s..hpKs..cpsRpch.cphhKhpctt+tEt..t.tpc+ccp++tc+-chhpp.ss-cQ++h-.........c+cpc+p.++.........	0	83	130	194
+7778	PF07947	YhhN		YhhN-like protein	Fenech M	anon	Pfam-B_5325 (release 14.0)	Family	The members of this family are similar to the hypothetical protein yhhN expressed by E. coli (Swiss:P37616). Many of the members  of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues.	25.00	25.00	25.60	25.00	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.43	0.71	-4.92	119	1531	2009-01-15 18:05:59	2004-09-20 10:23:20	9	5	1341	0	371	954	58	182.60	31	82.28	CHANGED	h.hphlhKshshlhLhhhsht......................sshshhl.hsuLhhShlGDhhLh...................pphFlhGlsuFhlAHlsYlhs.Fh.............thhtshphhhshshhshus...................shhhh...lhspl..............st..hphsVssYshllssMsht.Aht....................hhtshsthhsslGAllFllSDsll...AhscFh.......hshshsphhl.hsoYasAQhLI.shuh	..................................................phlhKslsllLLhlhshp.......................ts.hsshshhl..lsGLsh.ShlGDsLhh.............................................hsppphhhuluuFhLuHLhYshhFs...................tphshs..h...hh..s.ls.ls..l...h.ll.us...............................................................l.hhsl.......lhscL...............................tc...hphPVss.ahshlhsMshh..Asthh.............................................hhtsss.suh.shhGA.hLahlSshl.l.hhs+ap....................pphpts.s.hll...husYauuphLIstS.................	0	101	189	287
+7779	PF07948	Nairovirus_M		Nairovirus M polyprotein-like	Fenech M	anon	Pfam-B_5426 (release 14.0)	Family	The sequences in this family are similar to the Dugbe virus M polyprotein precursor (Swiss:Q02004), which includes glycoproteins G1 and G2. Both are  thought to be inserted in the membrane of the Golgi complex of the infected host cell, and G1 is known to have a role in infection of vertebrate hosts [1].	22.00	22.00	22.90	35.40	20.60	21.90	hmmbuild  -o /dev/null HMM SEED	645	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.36	0.70	-13.20	0.70	-6.40	6	90	2009-01-15 18:05:59	2004-09-20 11:34:11	6	2	7	1	0	87	0	473.40	69	41.74	CHANGED	PTNRSKRs.pscIILThsQGLKKYYoKILKLLcLT.EEDoEGLLEWCsRhLupsCDDsaFpcRIpEFFl..TGcGaFNEVL.FK..S.o.usThsPs+su.....usss-PF+SaaAKGhlphDSGYFSAKCYs+ASNSGhQLINlTpHshKlssTPGPKhoNLKolNCINLKsSsDK-HsElEINVLlPQVAVNLSNC+Vll+SHVCDYSLDsDGsI+LPplp.HpG....oFIPGTYKIlIDKKNKtNDRCsLhTNCVIKGRElRKGQSsLRQY+TEI+lGpspuGoRRLLS.Esuss-ClSRTQLI+TEoAElHsDcYGGPG-KITICNGSTlVDQRLGSELGCYTINRIKSaKLCENSAouKuCEIDSsPVpC+QGaCLKIoQEGRGHVKLSRGSEIlLDsCDoSCEIMIPKGoGDILVDCSGGQQHFLpsNLlDLGCPNlPLLGKMAIYICRMSNHPKTTMAFLFWFSFGYVITCIhCKllFYlLIllGTLuK+lKQYRELKPQTCslCEssPVNAIDAEMHDLNCSYNICPYCASRLTSEGLsRHVsQCPKRKEKlEETELYLNLERIPWhVR+LLQVSESTGlALKRSSWllVLLlLLsVSlSPVQS....APlupu+sVpsYpsREsYsuICLFIhGSVLhAlShLh+GLlDSlG	..................................hhph.h.t+lLphhths.-.ss-tL.pWCpc.ht.sCssshhppRIpEFFh..supuhFN-VLph+h.s.s.tso..ss..st......sss.shhp.hu+t.Lph.SshhpspChsts.ssu.Qhls...Hss+lhpTsGPKhpsl+slpClNlcsph.K-pp.l.lsVLhsplsVsLpsC+s.Ipu+.C.YshshDG.l+lPphh.+pG........hhh.GsYpIslDhpsp.NcpCpLhTsCVlKG+El+KGQS.L+tYpTEl+lsps.sGpR+LLu.ctsss-ChStTQLh+TEssElHsDsYGGPG-KITICNGSTlVDQRLGSELGCYTINRV+oaKLCENSAosKsCEIDShPVKC+QGaCL+ITQEGRGHVKLSRGSEVVLDsCDoSCElMIPKGTGDILVDCSGGQQHFLcDNLIDLGCPpIPLLGKMAIYICRMSNHP+TTMAFLFWFSFGYVITCIhCKslFY.LIllGTLGK+hKQYRELKPQTCTICETsPVNAIDAEMHDLNCSYNICPYCASRLTSDGLuRHVsQCPKRKEKlEETELYLNhpRlPhhlRpLLplS.usGhsLKRusWhhsLLlLhhlolSPVQu....APlGcGKTIEsYpsREsaTSICLFlLGSlLFlVShLhKGLVDSlu............	0	0	0	0
+7780	PF07949	YbbR		YbbR-like protein	Fenech M	anon	Pfam-B_4990 (release 14.0)	Family	The members of this family are are all hypothetical bacterial proteins of unknown function, and are  similar to the YbbR protein expressed by Bacillus  subtilis (Swiss:O34659, Swiss:O87088). One member (Swiss:Q97EN2) is annotated as an uncharacterized secreted protein, whereas another member (Swiss:P43521) is described as a hypothetical protein in the 5'region  of the def gene of Thermus thermophilus, which encodes  a deformylase [1], but no further information was found  in either case. This region is found repeated up to four times in many members of this family.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.74	0.72	-3.86	190	4025	2009-01-15 18:05:59	2004-09-20 11:52:03	7	7	1621	2	591	2564	94	83.70	18	58.23	CHANGED	lPV........psphspsh..lsshps....pssp.VplpGsp.shl......sslpphps...ps....Dlsslsp......sh.shp.....lsl..hssssssph...........Psplp..Vpl	.............................l........h.st.....s.ssh..tl..t.sh.ts..........pstp..V.plsG.sp..shl..........................ppl..p.p.h.ps.....ps.......Dl.ss.lst...................sh.shp..........lpl.......ss.st.ssph..............Ps.plp..lpl...................................................................	0	239	414	504
+7781	PF07950	DUF1691		Protein of unknown function (DUF1691)	Wood V, Bateman A	anon	Wood V	Family	This family of fungal proteins is uncharacterised. Each protein contains two copies of this region.	21.70	21.70	22.00	21.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.47	0.72	-4.14	38	223	2012-10-03 07:11:12	2004-10-06 09:55:10	6	5	115	0	163	218	1	114.70	21	62.00	CHANGED	sshluhHhhsspllPlls..sssuupssLthlptlhtpts...........hthhlLlsssshHlsuGhshhhthp..........................ptpp++pthhhl........................sshstlG.....hulhhhu.thp.h.t.s.............ssa	....sahuhHhhsspllPlhs.....s....ssu.....opssLthlcphhtp.s...........hthhhLlsssshHlsuGlshhhhhp.................................pppt++htthhh...................................t.s.hs.....hshhhhh.h.t.................ht.hhh.........................................................	0	25	72	131
+7782	PF07951	Toxin_R_bind_C		Clostridium neurotoxin, C-terminal receptor binding	Finn RD	anon	Pfam-B_3087 (release 15.0)	Domain	The Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1].  This domains is the C-terminal receptor binding domain, which adopts a modified beta-trefoil fold with a six stranded beta-barrel and a beta-hairpin triplet capping the domain [1]. The first step in the intoxication process is a binding event between this domains and the pre-synaptic nerve ending [1].	25.00	25.00	50.90	50.90	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.82	0.70	-4.64	10	143	2012-10-02 19:42:32	2004-10-06 11:27:06	7	3	31	75	3	169	0	187.30	42	17.41	CHANGED	YsspssoslLKDFWGNsLpYDKEYYllNlsp.N+Yl.....shp..oc.l...h.htt.p....ph.NhahNtppLYpGhKlIIK+hu...ssssDshVRpsDhlYlNh.shsNpcYp.Lhhps......spst.tpcll.hhclussssshsphhlhphp.hsshssY.Co.lFpsss..sNslGL..lGh+p.....s.....p..hsslVASsWYhsplccp.pp..sGCaWpFIPp-cGWsE	..Ypsps.sshLKDFWGN.LhYsKcYYhlNhhp.NpYIshp..psuh...h.....Rs...ps.shalN.p.LYpGhKhII++hu...pussDslVRcsDhlYlsh.hspspEap.l...h......tpsp.tEKll.hhpIsssstths.hhshp.p..ss.ssh.Cph.Fppsp..sspIGL..lGhHp...........p..hshhltSpWYhpplccps.s..hGC.WpFIsc-cGWtE.....	0	1	3	3
+7783	PF07952	Toxin_trans		Clostridium neurotoxin, Translocation domain	Finn RD	anon	Pfam-B_4943 (release 15.0)	Domain	The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. Subsequent to cell surface binding and receptor mediated endocytosis of the neurotoxin, an acid induced conformational change in the neurotoxin translocation domain is believed to allow the domain to penetrate the endosome and from a  pore, thereby facilitating the passage of the catalytic domain across the membrane into the cytosol [1]. The structure of the translocation reveals a pair of helices that are 105 Angstroms long and is structurally distinct from  other pore forming toxins [1].	25.00	25.00	27.40	26.10	20.00	18.80	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.97	0.70	-5.53	8	149	2009-01-15 18:05:59	2004-10-06 11:34:15	7	5	32	46	7	144	0	292.30	51	25.87	CHANGED	slFaYLaAQKhPcshpsIoLTsSl--ALLsssKVYTFFSS-aIspVNKsVpAuLFlsWlppVlsDFToEuoQKSTlDKIADISlIVPYIG.ALNIGNEstKGNFcsAhElsGAuILLEFlPELhIPllusFoIcSals..pNKNKIIKTIsNALccRpcKWcElYuaIVosWLo+lNTQFsphKEQMYpALpNQssAIKpII-YcYNpYot-EKspIss-aNIpsIcscLNcKlshAMpNIs+FlsEsSlSYLM.Khh..htlcKLp-FDsslKstLLsYIhcNpthLs.splscLpshVNsoLssoIPF....cLSpYTsDpILIphF	...............shFaYLcAQchsps.psIsLTSSh-cALLppsK..lYTFFSo.....-..aIcsl..NK..sVpA.uLFlu....WlpQll.DFTpEssppoThDKIADISlIVPYIG.ALNIGNpstKGNF...pp...AhplhGuuILLEFhPE..lhIPsltsFhl..Sal...pNKsclIcsIsNALpcRscKW.....c.....-hYthIVupWLoplNTQF.pl+EtMYpALp.QspAlKpIIchcYN.Yotc.....E....Ksplp..pash.slps.....cLNppls.AMpNIscFls-sSlSYLMKphhPhtlp+Lp-aDpslKp.LLsYI.cpp.hLh.spspcL.pshVsppLpssIPF....pLSpYTssplLlphF................................................................................................................	0	1	6	6
+7784	PF07953	Toxin_R_bind_N		Clostridium neurotoxin, N-terminal receptor binding	Finn RD	anon	Pfam-B_1058 (release 15.0)	Domain	The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein.  The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. This domains is the N-terminal receptor binding domain,which is  comprised of two seven-stranded beta-sheets sandwiched together to form a jelly role motif [1]. The role of this domain in receptor binding appears to be indirect.	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.45	0.71	-4.81	13	203	2012-10-02 19:29:29	2004-10-06 11:35:29	7	7	33	77	5	232	29	185.80	43	15.67	CHANGED	sNhlhDhSGhsoplphssDltLs..lNsssltLpsssp...sVshsNslhhNuhhsNFSIsFWlRhsphssp........chslIssh.csN....sGWcI.lcsNsllaolhDsNGpp+slah........SDhl.NpWaaITIosDRLpsp.hIaINspLlsscsIcslhNIauSNsIsh.....lscNp.IaIcthsIhsKpL	.................................................pNtlhDhS..GYsoplphscsl.tLss...lspN.phtLpus..sp...p.lpls..sNsIlaNuhapsFSlSFWlRIsphpsp........cYTII.ssh..cNN.....SG..W.cIsl...p...s...s...t...llaoLh.DssGppcslh...Fp.t...thSDYI..N+WaFlTITssRLssp...hIYINGpLlsspsIcpl.t.sIauSspIhhthst........s...hsp...sphlaIchFsIFs+pL........................	1	2	5	5
+7785	PF07954	DUF1689		Protein of unknown function (DUF1689) 	Groocock L, Finn RD	anon	Groocock L	Family	Family of fungal proteins with unknown function. A member of this family has been found to localise in the  mitochondria [1].	25.00	25.00	35.60	51.40	24.90	20.30	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.87	0.71	-4.35	13	52	2009-01-15 18:05:59	2004-10-06 11:36:28	6	2	43	0	33	49	0	161.10	33	56.82	CHANGED	acsulcFYEtDppL-spDRhpLucshpoluhushhuGasuhsuuFhsPhsYhta....pstul+GlssP+.............oFllGlsuhhlusphsu+htas+plpphcs.........................................sspp+phcsh+hhchspsuhashYYhpTupsPphpl.DP+phhpp......LKcs	...acsAlcFYEtDphL-scDRLcLucshpoIuhuphhuGahuhhusFhsPhhYpha....pstul+GVpls+...............sFlLGlhshhhusphsu+hhYs+plsphcss........................................spsp+Qhshh+hh-.s..ssutashYahhThpsPph+l.DP+shhpp.....h+...........	0	5	17	31
+7786	PF07955	DUF1687		Protein of unknown function (DUF1687) 	Groocock L, Finn RD	anon	Groocock L	Family	This is a putative redox protein which is predicted to have a thioredoxin fold containing a single active cysteine [1].	20.90	20.90	21.10	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.91	0.71	-4.18	9	121	2012-10-03 14:45:55	2004-10-06 11:38:47	6	4	117	1	95	114	0	139.10	28	85.85	CHANGED	MShF+TLQ.pP.csIoLFspsttst..upclhphLcpshssp.............Fcl-l.sschPThDQLphhts.h.ps..........pshltsphP....................................chpplhcphscs...tp...pshtsshap.....tPLhVDW-pshlus-......hpslcchL	................................................................a+.h.pp....csITLFHpsstss..Sp+lhslL+ps.suss.ttsss.........................pF-.L.-l...spc.PThDQL+hIl-ahsts.h............sshlpssh...........................................p.pcsl+thpps......................t..s..tFp.....cPlsVDWsNG.p..hust...............................	0	18	51	80
+7787	PF07956	DUF1690		Protein of Unknown function (DUF1690) 	Groocock L, Finn RD	anon	Groocock L	Family	Family of uncharacterised fungal proteins.	28.40	28.40	28.50	28.60	27.90	28.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.69	0.71	-4.21	7	160	2009-01-15 18:05:59	2004-10-06 11:42:59	6	3	127	0	118	152	0	114.40	28	78.45	CHANGED	VasPpoPlsFSpsLluQL-sSsEoDaoRpQhsE+alpc+VupcLppLE.EslKcFcspLpsShhss.cs.psspsslSostlspclcsLpp+Lp...pLpptchpK......t.cchpss.....RuclscCLhcNcsKPLNCa-El-tFKchsh	...................................s.hthStshlppLp...s...s...........EoD...s..Rtp.hEh.lpt+lu...tcLpc...l...pt...p...p.......t...p...h...p...p...h..h.....pt.......t........................t.....tttt.p....tl...........SptplppclptLp.t+Lp....t.plpphp.t..............ppu.......+ptllpCLptNpt..+PLsCacEV-tFKp.V.t.......................	0	25	58	97
+7788	PF07957	DUF3294	Ribosomal_MRP8; 	Protein of unknown function (DUF3294)	Groocock L, Finn RD	anon	Groocock L	Family	This family was annotated as mitochondrial Ribosomal protein MRP8, based on the presumed similarity of the S.cerevisiae protein to an E.coli mitochondrial ribosomal protein; however, this similarity is spurious, and the function is not known [Wood, V].	20.00	20.00	20.00	21.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.44	0.70	-4.81	10	45	2009-01-15 18:05:59	2004-10-06 11:45:09	6	1	44	0	30	36	0	208.10	43	98.55	CHANGED	MS...-.....lEpL+KcVscLpslV+KQutLIuKTGcpVl-LQlsppKschsshs.......sppspp..suplDsoDaATNEDLVQLVsELQGQLDsLE-RSIRRhsNSp..tp--c-llAPIPNtDG-hPs.p.......DthhPcTLcEFccl.-clcLh+Lu+FYEllPPs.p-pEchcchLcs..psEshch........sttsDc-lpcclcchoc-ElD-l..Fc-lARYLGLRsRRGossW	...................MSsc....lE.LpcpVs-LpsLVKKQShlIoKTGppVLELQlccpKpclsshs.......sppsss..ssphDsoDaATNE...DLVQLVsELQG....QLshlEERSIRRllNSp...ppcD-D.llAPLPNsDG-lPs.........-slFPpTLcEF+cl.sclcLl+Lu+FYEhlPPs.pEpEch-.phL-s....psEshpl........spss-c-IpcclcpaSc-plD-h..Fs-lARYLGlphRRGophW..................	3	7	17	27
+7789	PF07958	DUF1688		Protein of unknown function (DUF1688)	Wood V, Finn RD	anon	Wood V	Family	A family of uncharacterised proteins.	25.00	25.00	49.70	29.80	22.60	21.90	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.48	0.70	-5.94	32	232	2009-01-15 18:05:59	2004-10-06 11:46:41	6	3	181	0	163	231	29	398.00	45	92.28	CHANGED	shLpohpAVR-Rupplh...phAcpschpHFslc.s+hsssAsaVsslI+ccYss....pIP.HuRWpHF-sGG....lsRhspLhsphs.....................-s.EpuRthlDLhlVSVLLDAGAGspW+YpEstssph....auRSEGLAVAShchFhsGhFSu.DsscPhpVDupuLppLohppLupuFQVoss.NPLsGLEGRspLLp+LGcuLtspsplF.....Gsp...uRPGsLlDaL.............tsssss.lshsplhssLhssLsPIWP.uRsplcGh...sLGDsW.pssl.......................sss.ssullPFHKLoQWLsYSLlpPhpp..hGlplssh-hLTGLPEYRNGGLhlDhGVLsL+cssht....................h.sassscshIVEWRALTVuLLDcLtshVpppLs..hssppLsLAplLEuGTWpAGRclAtppRPp.usPPItIhSDGTVF	.............................................................aL+SlpAVR-Rsphlh...phA..p.pscLsHFslc..s+hsssAsaVsslI++cYsss......sIPsHuRWpHF-sGG.......hsRlspLhpphs...................t.hDshEcsRphlDLhlVSVLLDAGAGspWpYc.-s.t..oGph.............apRSEGLAVASLcMFpsGhFSu....-s.s.....p.Ph.pVDutuLpplosptLupGhQlots.NPlsGl-GRssLLpRLGcuL...sps-hF.........Gtp............uRPGsh..lDaL...........................ttsussshlshsslWssLhs...sLsPIWP....uR....splsGh..................slGDsW.pssl................................................sst.hpsllPFHKLoQWLsYSLhtPhpc..hslphssh-hLTGLPEYRNGGLhlDhGlLsLKstsht....................hshapss--lIVEWRAlTVulLDcLtshVpppLs..hssppLsLAplLEuGoW+.................uGRclAttpRP....s.......ttPPIhIhSDGTVF......................	0	46	87	133
+7790	PF07959	Fucokinase		L-fucokinase	Adamkewicz J, Finn RD	anon	Pfam-B_121298 (release 15.0)	Family	In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by L-fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalysed by GDP-L-fucose pyrophosphorylase [1].	27.50	27.50	27.50	28.90	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.37	0.70	-5.91	6	272	2009-01-15 18:05:59	2004-10-06 11:47:43	7	11	161	0	110	250	6	326.70	26	42.43	CHANGED	uGG.S+RlP.AsshGKlFTsLPh...-pspt....Lss...plLsLp.shhpcF.spu..Gl..hlsouD...lhsss-s.hlshsc.susssluhPsoLslAosHGVaVscppss.tc.shphpllcchLpKPTlE-lhphpAlp+sGphhh......DoGll.hcscss..-sLhthshpsuphhlsah-L.lsshp.EhshYtDhltAhuPu...Ea......sphsocsht.t..hh.hRp+haphhpt.slshl.lssupFhHhGTop.EhLp+hous.ssl....tlsp+phss.Pshpsps.ttossIloShlsuslSlussSl.lppS+LusslpIGupCIVoGl.lhppsuh.u..........L.DhlC..hcVhhsGslphVhhhhGlpDNhKsSl+p....cuhpFhGhsappsLcchsIcsoDlhsSss..pshsLWsA+lFPVhoshc	........................................................uGG.SpRhP.hsshGKhhoslPh............tpsp..h.......l.p....phhpL..shh.ch..tthss.G.l..hlssuD........lh.hs.....t....p...h........p.....h.........sp....s.....shh..s..huh.s.s.shupsHGVal.sp.........p.......s..............................lp.hLpKsohpch...t.sl...........ts.t..h.h....................s.Ghhh.h..sschs.........-.Lhth.p.h...ps.s...h.p......hs.....hh........t..........h....................t.h.....sha.Dhhhshu.........c....................sp.t.pt.h...........................p..t..s..lshh.....l......ss.....upahahsTo....t...E..hlpphht.....th.........................th..ttp.h.........s......................hl.suhl.pst...h..ph.ssssl..lp.spl.ts..s...hpluptslloGh...p.......th................................shhh....p..lh.................s......p.....t...hshh.hGhpDshctt.......tt.tahshsh.phh.t..hslp......-hh..ts.....sL.sAplFPlhp...p.............................................................................	0	40	59	81
+7791	PF07960	CBP4		CBP4	Groocock L, Finn RD	anon	Groocock L	Family	The CBP4 in S. cerevisiae is essential for the expression and activity  of ubiquinol-cytochrome c reductase [1,2].  This family appears to be  fungal specific.	20.60	20.60	21.60	23.10	20.10	20.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.77	0.71	-4.52	18	129	2009-09-10 15:02:01	2004-10-06 11:49:54	6	2	125	0	95	123	0	115.40	33	85.79	CHANGED	p+ssWhhWsKhhhsGusIhsuGshLhpYhoPTDE-Llp+asPEL+pch.cpRchRQpE.p-hhphlKcpSKSDcPIWpsushcS...E.+c..............p+pctt..pt.php+tppEhcchcpppppp+c-	........t....hhhWhKhhss.GuslhsuGshLhpassPT-E-Lhp+asPELp+c..cpR..ctRQpE...pchhpplK-hS...cSD......cPIWtsst.ps...Ecp...pt.pt................ht+.ptcp...p+pphtchtt...............t..............	0	19	49	80
+7792	PF07961	MBA1		MBA1-like protein	Groocock L, Finn RD	anon	Groocock L	Family	Mba1 is an inner membrane protein that is part of the mitochondrial protein export machinery [1][2].  It binds to the large subunit of mitochondrial ribosomes and cooperates with the C-terminal ribosome-binding domain of Oxa1, which is a central component of the insertion machinery of the inner membrane. In the absence of both Mba1 and the C-terminus of Oxa1, mitochondrial translation products fail to be properly inserted into the inner membrane and serve as substrates of the matrix chaperone Hsp70 [3].  It is proposed that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosome exit site to the insertion machinery of the inner membrane [3].	27.40	27.40	27.40	27.40	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.27	0.70	-5.52	7	74	2012-10-03 02:27:23	2004-10-06 11:51:34	6	1	72	0	48	79	0	223.40	28	77.91	CHANGED	ppsppc.pshs.+alGlhs-halPsua..h.sshssPhhhhphLhRRhYhhulNThpluhFRhpoGhKPpFh.WKNcAIEsYlpVNcuFAp+sL...........pplcshsolWVpcALptRu+plPsssch-WpLlKFssVPKLluhpsh.lPspshE.hlQllY+FcT+Q+Ll+hs+tssKs-phD+sVl-YlualpDuoTs..-hlLhGSVFESs.scshLPcss.sssplslppM+ssGDIaR.ssu	.................................................................................hs.p.lG.lhschalPsth...hss.htp.s.h..hhphl.hR+hhhhshN.......ohplh...ha.+..h...p.........u..h.....+.....p.Fh.WKspAIEhalpsNpuFAptsl.................splcthsu....hhl.cuLtsRs...p.....phP.t..s.s.pLsWpLlKasps...P........KlVS..h...psh.l........s..s...t.s...h.p....hlQlVh+hsT+Q.....+l.l...p............hs....ptp...p..........p......s...pph....-....+..Dls-YlVa.....h..s.shss....-hhlhGplFESp..psh..s...p........stp.h.t.....tuDlaR....t.......................................	0	11	26	43
+7793	PF07962	Swi3		Replication Fork Protection Component Swi3	Wood V, Finn RD	anon	Pfam-B_9217 (release 15.0)	Family	Replication fork pausing is required to initiate a recombination events.  More specifically, Swi1 is required for recombination near the mat1 locus.  Swi3 has been found to co-purify with Swi1 Swi3, together with Swi1, define a fork protection complex that coordinates leading- and lagging-strand synthesis and stabilises stalled replication forks [1]. The Swi1-Swi3 complex is required for accurate replication, fork protection and replication checkpoint signalling [1,2]	25.00	25.00	25.20	25.30	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.76	0.72	-4.35	29	279	2009-01-15 18:05:59	2004-10-06 11:52:44	7	7	238	0	196	269	2	84.40	34	27.13	CHANGED	KLcsp+LhSp.+GlPtLc+t....................h.cch+hpu+s+E......................hs-LspllphYQhWsHcLFPKupFcDhlshlEpLG+p.+plpshhpchhpcth.	........................................................KLstpRLlup.cGlPtLp+h.............................h..cph..K..h+.G.K.GHE................................hpD..LppLlphYphW.sccLaP+hpFcDhlshlEpLGpp.+plp.shhpchh.c..s................................	0	58	101	157
+7794	PF07963	N_methyl		Prokaryotic N-terminal methylation motif	Bateman A	anon	Pfam-B_6484 (release 14.0)	Motif	This short motif directs methylation of the conserved phenylalanine residue.  It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596.	21.20	20.50	21.20	20.50	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.24	0.73	-6.49	0.73	-3.90	72	4741	2012-10-03 10:38:27	2004-10-06 12:39:50	7	22	2129	0	985	9899	3456	19.90	44	11.31	CHANGED	pGFTLlElllslsllullhs	...+GFTLlElllVlsIlulLs...........	0	364	650	834
+7795	PF07964	Red1		Rec10 / Red1	Wood V, Finn RD	anon	Wood V	Family	Rec10 / Red1 is involved in meiotic recombination and chromosome  segregation during homologous chromosome formation.  This protein  localises to the synaptonemal complex in S. cerevisiae and the analogous structures (linear elements) in S. pombe [1]. This family is currently only found in fungi.	25.00	25.00	41.40	41.40	24.40	22.60	hmmbuild  -o /dev/null HMM SEED	706	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.24	0.70	-6.37	6	28	2009-01-15 18:05:59	2004-10-06 13:14:18	6	2	24	0	18	30	0	598.10	30	82.59	CHANGED	hllLclhapssph+plItpLlc...scashplG.LlDN.IpDhQLsNallElLSpsFs++usspstlsphPpL.WpcppKsK.FFppphYPapuKaGsttlhpFlhsp..FushlsNhs+l+plhashust..pspsltsLsppscpt.hahQsIasplYhWsGEssFlclc+.KslcIh+-L+splcl....Klhs.sFccslpospcthht...........TlppsptFpl-Fp-pphschahps.sNlPKISEVQsalsLpa.pp.--p.I-spspc-pso+cpsl.ppcptssss-u............hphutpcspa-p....TP-+s...htpcssl.DL........ppssccpc...cshss.Klp.ppsph.psph.pllppp....pSPlsphQc+KltRssSKoh.........c.L+psh-cpt....lpsppspScpshspshpsssslsspsplpss........tutcltsphsucp.pssssVsshochpssKohKppDlsl....L-sIFupPlsKtp+p...K.p+pKQ.hLpNhhshh..........KoKh.ltsNsppsh+optlpptcosphss..ph..........sppusP.s.tch.tcQssoosshtpss+sshcs+sPptpppKlEshststphssh.........sKpNsts.sp.ss.cpth..tpp.t.sshp.......................shu-STTIss.sup..s........FTspLQ-QIapSIspFSsELppKIuIINpEhNpKIl+ELSEKYpplF+-LppsFpsDspcMhpFVGElK-MhpLPE-pLVptIRs+pF	......................................................s.hl.plh.phs.p.+phIhpllc...scastplGplhDs.lpDhQ.sNaLlElLSsCF.+psssphtl.phPpL.W.ppcp.Ks.c.FFpsp.YPapuKpGp.pshpFlhpp..Fhspl.s.hshl+plsYssup...p.pslchh...p.tpsc..p..halQsIasplYlWhsE......p..........t.lEhc+.KplcIsK.sLKsplpI....+ltp.shppslpostsphhh...........hhs+s+tFQL-FpDpphs-pFapshsNlPKISEVQsFLsLsah-p.s........-sphp..c-pp.tpss..tpppptpps.sp.................hp.uhspspt-...lhTP-cS...sph+oDtWDl........pssopppp...sshss.Kls.pp.pphppp..p..pl.pc-......................QSPlV.sQhRKhtRpoo+TL.........EhL+p-Fpppt..................lpsppspspp..s..htp..sshlhtpsphhps...................ppp.p.s.pshthschpsspSlpK+DIsl.........LsTIFupPssKtp+p.........K.ppppQppLpNaK.Pllpl..............spsc..lps.ss.tps+shclpphposphsp...............tp.spsttttch.ppp....s.sposs.pthspsscctphsc.stt+.p.tptptphsh.....................sppssts.sp.ss.pp....ths.sps.pssslo.......................shh.-STTlls..hps...s......................ssFTspLQEQIasSIspFSNELh+KIsIINpELNpKIl+ELSEKYQpLFt-LQpsFQsDspcMhpFhGEIK-hhpLPE-pLVphIRs+KF................................................................................	0	2	8	17
+7796	PF07965	Integrin_B_tail		Integrin beta tail domain	Bateman A	anon	Pfam-B_1876 (release 14.0)	Domain	This is the beta tail domain of the Integrin protein.  Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.	20.10	20.10	20.30	20.10	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.32	0.72	-10.88	0.72	-3.55	58	524	2009-01-15 18:05:59	2004-10-06 13:37:43	7	25	119	21	230	460	0	83.70	32	9.93	CHANGED	C.spp+cCVpCptFpsG.h..pc....sCstpCpph.l..phVcphppps...........Cph+Dp-.-ChhhFshp...psss...sphhlhVhcch.-CPpuPs	...........................Csp++sCVpCptFspGph....pp.....sCsptC.pth.l...phVcph.....pcpspss...........tCph+Dp-.D...ChhtFsat........tsss......scshlpVlcc......-CPpuPs.........	0	30	46	122
+7797	PF07966	A1_Propeptide		A1 Propeptide 	Rawlings ND, Finn RD	anon	Pfam-B_386 (release 15.0)	Motif	Most eukaryotic endopeptidases (Merops Family A1) are synthesised with signal and propeptides.  The animal pepsin-like endopeptidase propeptides form a distinct family of propeptides, which contain a conserved motif approximately 30 residues long. In pepsinogen A, the first 11 residues of the mature pepsin sequence are displaced by residues of the propeptide.  The propeptide contains two helices that block the active site cleft, in particular the conserved Asp11 residue, in pepsin, hydrogen bonds to a conserved Arg residues in the propeptide.  This hydrogen bond stabilises the propeptide conformation and is probably responsible for triggering the conversion of pepsinogen to pepsin under acidic conditions [1,2].	20.50	20.50	20.70	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.93	0.73	-7.15	0.73	-4.01	85	802	2009-01-15 18:05:59	2004-10-07 15:04:45	7	5	152	8	295	720	0	28.40	36	7.79	CHANGED	ll+lPLcKh+SlRcsLpEpGhhpcaLcpp	.....lh+lPL+KhKSlRcsLpEc...GhhpcaLcp........	1	23	33	100
+7798	PF07967	zf-C3HC		C3HC zinc finger-like 	Wood V, Finn RD	anon	Wood V	Domain	This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in  nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling  events [1]. The domain is often repeated, with the second domain usually containing  a large insert (approximately 90 residues) after the first three  cysteine residues. The Schizosaccharomyces pombe the protein containing this domain  (Swiss:O94506) is involved in mRNA export from the nucleus [2].	20.80	20.80	20.80	20.90	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.15	0.71	-4.40	28	278	2012-10-01 20:49:39	2004-10-07 15:12:26	8	8	216	0	192	304	7	127.90	26	24.50	CHANGED	Phs+tsahpRLcTFpshs.W..........ssKPstloslpsA+pGWhs..hs......p-tlpCp.sCpspLshp..........................sphstphhcphsccatttlp.suHcpsCsW+spsss.cthtths..lsts.pshlsshtc.....chssLhph.....spLPhhss	..............................hs+pshhpRlpTF.....p...t...hs...W..........tsKPp.tlsslthA+pGWhs.....ss............t-hl...cCs..sCp..stLshp....................................sthshp...hhpph...s...pch.tp.tls.s......uHpp.C.Wt....spsss.cphhhls.....hsps..thhlpthhp+hppLhph..........t.............................................................................................................................	0	55	103	156
+7799	PF07968	Leukocidin		Leukocidin/Hemolysin toxin family	Bateman A	anon	SCOP	Domain	\N	20.40	20.40	22.20	21.40	17.00	16.10	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.59	0.70	-4.74	19	1628	2009-09-11 18:55:27	2004-10-27 16:53:05	7	6	341	102	22	554	5	237.50	36	70.82	CHANGED	pslQFsFlcDtpaDKcslllphsG.pIsSshphsssps......phspthhWs..........tpYslul..ssssssspllc..hhP.KNp.cphpVppThGYslG..Gsl..pl.psGPs....huusuoasaScoIsYsQpsY+oplsppssp.slsWsVctsphsssstt...........shasp.lFhhscppss..supp.FlspschPsLspuGFNPpalsllopcpssspoo.chclsYpRshD.hhshh.tp......hhstpsac..shps+phss...pYcVDWcs	................................................QslpFsFlcDppYsKcsLllKhpG...IsSthph.s.cs.........hsthhWP.................tpYsl..ul...p..sssssssllc..YhP.KNp.-otpVpp.TlGYshG....Gsh.......psu.o......hG.hsuuhsaScTIo..YsQpsYcTpl-.ppssc....sVtWsVcApphhsssht.........pssasp.LFhts+ssuh...tupp.FlspsphPsLlpSGFNPpFlsslS....+-..+..s.s.s..cpS.chcloYp.RshDhhphthspp............hhs.spsap..shhscphos....pY.EVDWcs...........................................	0	10	12	18
+7800	PF07969	Amidohydro_3		Amidohydrolase family	Bateman A	anon	Pfam-B_751 (release 15.0)	Family	\N	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.16	0.70	-5.26	43	5270	2012-10-03 00:45:34	2004-10-27 17:18:53	6	49	2463	42	1791	12984	4622	377.00	18	74.72	CHANGED	hlhPGFlDsHhHlhstshth..hhshtssh..shtthhthht......................hshsaspsthtptchs.sttsl..-tsts.stshhhtch.tphshlspt..uLph......................t.t.stshltppst....hhht................th.s.hsshtphtphhct.thtthsptGlssshsss..............s.tphhpshtplsppht.hsh.hhh.h......................................sshphhssGs.s..spsuhhtp..hsssh....phth....sttp..h.pplsptspppththplau.............ststulsphlsshcphhtp....................hhh+sphssspshcthtplshthshts........h...........hh.phhss.phphs....hshtthhssG.....hplshuoDhsh...sshsPh.hshtssshtpsht...t.hhh....................................pplsltculphhTtssAhh....hshpcph.GpltsGt.ADlsl	.............................................................................................................................................................................................................................................................................................lhPGhlD..sHhH......h...t.h..t.h..t......h...........................t........h....s.h...t.ssh..............s....h...t..h.t.................................................................h...s........t........h.......s.....t......t......p...h.................s.....h.tpl............c.t...ht.................s....hh....h.......t......................h.hspt......ulph.........................................................................t..tps...p..s...h.l...tpps..........thhht.......................hh.s................s......p..p.....h.t..t.....h...lp......t....hht.h.sp...h..Glsuh...sst.........................................................t......h...p....h..h..h....p...h...........s....t...p......s.............................................................................................................................s.u..h....h...h........s...t.t..........shs..u.h...h........t......................h.........s...p....p.........................................................................p.......s.................h..........s.pp...................l..pph..h...th...s.....t.....p..t..u..h...t.h.t...l.au...................................................................t.s...t.u.h.p...p..h...l.s...s...h....pph.hhp................................................................................hlt+.s...p...h....h....t........t...s.......h..t.......t..h....t....p....L....t...h..t...h..s..h.ts............................................................................................h.................c...t...p...t.h..................h....h.....t....p....h....h....p..t.G..................................h.tl.s.h....u...s..D....sh..............sshsP..h....hs..l....t....s....u..s....h.t....p..s.h...p............t.....h...h........................................................................................................................................................................ptl.s..l..p..p..A..l..p.hh..T.t.suAht............ht.hp.......c.t.......GslpsGp.ADhll.................................................................................................................................................................................	0	578	1162	1523
+7801	PF07970	COPIIcoated_ERV	DUF1692; Erv41; Erv46; 	Endoplasmic reticulum vesicle transporter 	Mistry J, Wood V	anon	Pfam-B_2028 (release 16.0)	Family	This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi [3].	21.90	21.90	22.00	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.89	0.70	-4.73	51	979	2009-01-15 18:05:59	2004-10-28 13:59:39	7	20	303	0	653	899	28	187.70	29	53.30	CHANGED	CYGAt..............stptCCNTC--VppAYtp+tWshsssp.slcQCpp-....h....ptphs..EGCpltGshpls+lsGshHhAPGp...shp.tthH.h...HDhp.hpp.........phNhoHhIpcLsFG......pp.....hs.t.............pP...LDshph.......t.pp.pt...hhapYalKlVPTpap............cospaSsspap+slpsst.............tuhPGlFFpY-hSPlplh.ppp+..pohtpFlsslsullGGlasluullD	...................................................................................................................................t.....-G..CplhG..lpVNKV.sG.s.FHhs.stp..............sh.................th.t...................................ht..htt.....................phNhoHhIpc...LSFG....pt........hsshh..........................sPLDssph..................tp.p.t............................hhapY..alclVPThY.phttt............................h.popQaSVT.p....pp...cshptt.................................tslPG.laFpY-lSPhhVh..hpEp+...psahpFlsplCuIlGGhhsluuhl......................................	0	250	385	541
+7802	PF07971	Glyco_hydro_92		Glycosyl hydrolase family 92	Mistry J	anon	Pfam-B_1199 (release 16.0)	Domain	Members of this family are alpha-1,2-mannosidases, enzymes which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation [1].	24.50	24.50	24.80	24.60	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.66	0.70	-5.86	187	2270	2012-10-02 14:50:22	2004-10-29 16:03:55	7	44	847	40	652	2109	326	474.50	31	62.78	CHANGED	u.pph...t.uhlpF...st.....spp.......l...s+lulSalS...h-pApt...NLct....Eh..........s..shs..F-pl..pppApstWscp.Lu+l.pV..p..........u.....ss....psp.....pphFYouLY+shltPphhs-........h.....sup..................Yp.u.....t...........................t.............uht........Yss.a................ulWDTaRuhaPLhsllpPp.hss-hlpShlsha.c..ps..........GaLPcWthsspp.stsMsGspussllADAa...hK..G............lp.shD......hc.pAacAh..h+sAp.............ps....................+sG...........lppah.phGYl..P...........................hsc...u.......sSpTLEYAYsDasluphAc.u...L...........Gcpp...............................-.h.ptahcRupsa+Nlacsp.......................................sGFhps+......p..ts..........G....s......at..........t......s.......asP..h.............th...s.......psah.EGsuW....pYoahV.PHDhsGLl.pLhGGc..................ct...........Fhp+LDphFst....ht......................hGpY....s.hGNEPuaHhsYLYsas.GpPa+TQphlRplhsphYs..sss..sGls.G..N-DsGpMSAWYlaSu.lGhYPlsPG...sstYhluoPhFccssl...pL.........................sG.......+...s.hsI....pA.pssu........tc.s.........hYlpusplNGcshs....+..sa..lsHsc...lh..pGGpLpapMuspP	...............................................s...tshhpF...t.st...spp.......l.ph+luhSalS...h-p.....Apt.....NLpt.Eh..........s...shs...F-..ph..pp...pupstWpph.Lu+.l.pl...p...................s................ss....psp.............pphFYosLY+shlhPphht.-.h.......ssp..........................Yp..sh...pt...................................pht..s.t...h.....Yos..h......uhWDTaRshaPLhs.Ll..P.c.t.h.pchlpuhlsha.c..ps.................G..a.L.P...cW....hs.....sp..........c.s................shM..........sGstussl...lADAahK.....G.............lp...shD.......hp...puapAh.....hcsAp..........t.............................s+tu...........h.t.t.Yh...chGYlP.........................sphpc........u..........lScTLEYAasDasluphAc.tL...........Gc.pp...............................p.t.pha.hpR.ut.s.Y.+.s.l.acsp.......................................s.Gahps+pss.................................Gs............at..................................s............s..........FsPh..................ph....s........psas.Eu...suWpYoa...........hV.......HDhtGLl.pLh..GGc..................c.s............Fhp+LDphFst....h.t.....................h.h.Gpa..s.huNpPuaHhsYLYsa..s.G..pP.....h+TQthl+p.....l....................h...................p...................p....h...................ap.................sss.........sGh...s..G..............s-DsGpMSAWYlaou.lGhYPls..PG....pspYslGsP.hFc.c.spl..pL........................t.sG....+p..hsIps..tsss..........tc..s.................hYlpphplNGc...........h..s.........p.sa..ls.H.pc....lh....pGu...pLpaphusp............................	0	232	458	572
+7803	PF07972	Flavodoxin_NdrI		NrdI Flavodoxin like 	Finn RD	anon	Pfam-B_1603 (release 16.0)	Family	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.55	0.71	-4.21	86	2192	2012-10-03 05:08:30	2004-11-12 15:12:44	6	3	1921	11	257	1337	42	121.30	41	86.07	CHANGED	lhasS.hoGNT+RFl.....c+Lsh...t.+hshp........thsp......hplscPalLlsPTYusGt...tsu........VPppVhcFLs..cNcphlpGV..........luSGNpNFGsp.ashAuchlup+hpVPhLhcFELtGTppDlpplpp	...................................lha.S.hSsNTcRFl.......p+Lsh.............u...c.hslp............ttpp.........hplcEP...al.Ll.l..P.TYGsGss....tsu...............VPctV.hcF...Ls.......t...p.N.....+....p...h...l.....+G....V..........luSGNR.NF.G.pt..ashAuch....Iup...+h..sV..Ph..L..h..+FELh.G.TppDlcpV+..........................................	0	54	135	202
+7804	PF07973	tRNA_SAD		Threonyl and Alanyl tRNA synthetase second additional domain	Finn, RD	anon	Pfam-B_270 (release 16.0)	Domain	The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain).  The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.06	0.72	-4.07	219	11375	2009-01-15 18:05:59	2004-11-15 16:21:20	9	40	4904	28	3159	8949	4659	48.10	36	6.80	CHANGED	lRll.....ph.G...s................hsh......-LCuGsHlpsTucI..ttF+lh.......ptsshspslpRIh	...............................lplh.....ph.G...-.................................h.....-LCtGs..HV.ssTucI...th.FKlh........................ptsuhsttlpRI...........................................	0	1065	1968	2631
+7805	PF07974	EGF_2		EGF-like domain	Bateman A	anon	Pfam-B_80 (Release 16.0)	Domain	This family contains EGF domains found in a variety of extracellular proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.44	0.72	-3.78	51	1990	2012-10-03 09:47:55	2004-11-17 13:40:45	8	364	173	0	1055	1784	147	30.20	42	4.71	CHANGED	C....s......Css...pGpCs........tthCpCpsu.....atGspC	...............C.t.............Csu....+GpCs...........sGpChCpsG.......apGssC....	0	399	519	772
+7806	PF07975	C1_4		TFIIH C1-like domain	Finn RD	anon	Pfam-B_10678 (release 16.0)	Domain	The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif.  The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C (Pfam:PF00130) [1].	24.60	24.60	24.60	25.20	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.47	0.72	-3.96	16	268	2012-10-02 13:15:50	2004-11-17 14:18:53	7	7	237	1	201	260	6	52.60	46	12.05	CHANGED	hCauCQpph.s...p................phYpCspCcphFClDCDlFIHEoLHsCPGCps	..........................................CauCptphss..............................................ptYpCstCpphFClDCDlFlHEsLHsCPGCt....	0	62	106	161
+7807	PF07976	Phe_hydrox_dim		Phenol hydroxylase, C-terminal dimerisation domain 	Finn RD	anon	Pfam-B_19435 (release 16.0)	Family	Phenol hydroxylase acts a homodimer, to hydroxylates phenol to catechol or similar product.  The enzyme is comprised of three domains.  The first two domains from the active site.  The third domain, this domain, is involved in forming the dimerisation interface.  The domain adopts a thioredoxin-like fold [1]. 	20.90	20.90	21.40	21.60	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.99	0.71	-4.65	78	504	2009-01-15 18:05:59	2004-11-18 16:03:01	7	14	183	10	351	544	44	164.70	24	25.89	CHANGED	FsuGhulcYssS.hLs..........spss.p.................................pt........LAsslhlGpRhhoupVlRhuDupshcLtctlpuDGRaRlhlFuGchpt.s..p..sh....s.plpplsphLs.sssShlp+assts.....................tphs.Sl.l-lhslapss+psl-lt.DlPp.lhpPhptphth...........Dap+lass.D.t..........pscsachh..G.lDccc.G	..................................................FsoGhulcYssu.hls.......tpss..p.................................pt......lussltsGpRh.ssp..VhRhuDupshcLpc......pl.us..Gp.aRlhlFu.Gs.pt.sp...h..........ttlpshs...phLt.t.p...Shlppassts..........................tt.s..Sh.h-lhh.l.......a.......st...+pp.l-lp.s.lPt.hhp.s......h...........sh.c.lass.-..............tsphaphh..G.ls.p..............................................................................	0	72	165	283
+7808	PF07977	FabA		FabA-like domain	Bateman A	anon	Bateman A	Domain	This enzyme domain has a HotDog fold.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.75	0.71	-4.69	51	6557	2012-10-02 20:54:35	2004-11-19 13:29:09	8	37	3882	226	1494	3917	3933	124.30	34	64.08	CHANGED	LPpch.hLhlDRlhpls.sGtp.....lhu.Kslo.s-.FFpsHF.scPVMPGsLhlEAhhQhsGhhhhht..tpspG.........h...ulscs+F+tpVhPss.plphclchp+......p+hs.huhucuhshVDGchlhpAc	....................................LPHRhPhLhlDRlh-hp.....t..........u.pp.......................lhAhKsVoh..N.....E.....F...F....p....G....H....F.Ps.p...Pl.....MPGVLllE.............AhAQ....s....s....G....lh.......hh.....tp...................t.tp.G......................thhhh..hGlcc.s+F+p..V.lP.G..D...pl..h.hclchh+........p+ts..hsh.hcuhu.h..V.DGc.llspA...............................................................	0	441	905	1223
+7809	PF07978	NIPSNAP		NIPSNAP 	Mistry J	anon	Pfam-B_3436 (release 16.0)	Domain	Members of this family include many hypothetical proteins.  It also  includes members of the NIPSNAP family which have putative roles in  vesicular transport [1].  This domain is often found in duplicate.  	22.30	22.30	22.30	22.30	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.04	0.72	-4.04	42	1376	2012-10-02 00:20:33	2004-11-23 10:06:50	8	10	733	16	670	1283	354	97.80	20	66.90	CHANGED	aE..lRsYplcPuphsta.hptatcthhthht.htschlGhahs...............phGs.hsplhtlasasshssRpthRsthhpDstW.ttthptstth..lpp.csplhhPsshSs	....................................E.htpYplc.P.s..p..h..t..p..a....hp...t....a.tc....t..h...h......h....h...p...t....h...s....s..chlGhah.s...............phGs...hspshtla...sap.s.....hpshcp....hRpt.hh.p....c....s....ta....tt..h....h...t..h..s.h..t....h....l.pp....csphhhsh................................................	0	183	323	489
+7810	PF07979	Intimin_C		Intimin C-type lectin domain	Bateman A	anon	Pfam-B_1879 (Release 16.0)	Domain	This domain is found at the C-terminus of intimin. Its structure has been solved and shown to have a C-lectin type of structure [1]. Intimin is a bacterial adhesion molecule involved in intimate attachment of enteropathogenic and enterohemorrhagic Escherichia coli to mammalian host cells. Intimin targets the translocated intimin receptor (Tir), which is exported by the bacteria and integrated into the host cell plasma membrane.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.59	0.72	-3.81	14	389	2012-10-02 16:37:33	2004-11-24 13:34:50	6	10	133	15	2	312	0	94.00	48	12.60	CHANGED	Pspl.IsVspps+ssYssApspCp..shuupLsSSpspLps......lYspWGAANKYpaYpupsoIoAWlpQTssDhpsGVuSTYDLVTpNsl.N......VsssssNAYAVCVK	.........Psph.ItV-ptp+ssYs-A.shC+..s.su.LPSSpshLus........lYssWGAANKYsaYpu.pSlTAWIpQTss-ppuGVoSTYDLlTpN.l.s......Vslss.NsaAVCVc...........................	0	0	0	1
+7811	PF07980	SusD	SusD_RagB;	SusD family	Mistry J, Bateman A	anon	Pfam-B_1855 (release 16.0)	Domain	This family includes several hypothetical proteins.  It also contains RagB, Swiss:Q9ZA59, a protein involved in signalling [1] and SusD, Swiss:Q8A1G2, an outer membrane protein involved in nutrient binding [2].	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.83	0.70	-4.87	151	6618	2012-10-11 20:01:00	2004-11-24 15:06:21	6	10	210	38	1597	6145	784	279.40	17	50.72	CHANGED	sEhIa......ththtt.ssssssshshthhhtstss............................tshsthts.........opphhsha............................................................................pspDsRhtt.shhh.tttht.....................................................................................htt.ststshsshhhpKahs.............................ttssstssstsh..........lhRhA-lhLhhAE...Ahh............chuss.......sp.....Ah..phlNp....l...R..pRA..................................................................uhsshs.s................................ssthhp...tlhp.ERthELshE.spR.ahDLhRh.................................................................................tthhpphtthttstpththtttt...........................................................................................lhPIPpsplsts............ssLp..Q.N...s........Ga	.....................................................................................................................................................................................................................................................................................................................................-.hh...................................................................................................................................sh.s...h.h.s.............s...p...h.h...p..a.................................................................................................................................t.s..p...D.....Rhth....s....hh.h....t..h..........................................................................................................................................................................................................................................................t...t.....t...t....s..h....s..s.h..h.....h.t.Kahs...................................................ttsstt.t...ss...t.sh...............................lh...RhAElhLhhAE....Ahs...................................c.hsss........................sp..............Ah.....phl.....N.p......l..........R..p..Ru.............................................................................................................................................................s.h...ss...h.s..s....................................................psth.h.p........tlhp.ERphE.Lsh.E....G....t.....R.ahDL.hRh.................................................................................................................................ttth..t..t..h..t.t.h.h...t..t..h.....t.......t..h.t.h.....t...................................................................................................................................................................hhP..I.P.p....s.p.l.p.hs......................st.lh..........Q..N...sua............................................................................................................................................................................................	1	756	1474	1596
+7812	PF07981	Plasmod_MYXSPDY		Plasmodium repeat_MYXSPDY	Mistry J	anon	Pfam-B_3138 (release 16.0)	Repeat	This repeat is found in two hypothetical Plasmodium proteins.	21.10	21.10	41.10	21.60	15.70	18.60	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.69	0.72	-5.92	0.72	-4.22	24	71	2009-09-11 18:54:15	2004-11-24 15:52:40	6	2	1	0	71	71	0	17.00	79	98.85	CHANGED	MYhSPDYTL.hVtLPDT	MYFSPDYTLRLVQLPDT	0	71	71	71
+7813	PF07982	Herpes_UL74		Herpes UL74 glycoproteins 	Mistry J	anon	Pfam-B_3076 (release 16.0)	Family	Members of this family are viral glycoproteins that form part of an  envelope complex [1].	25.00	25.00	29.80	29.50	17.30	17.60	hmmbuild  --amino -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.54	0.70	-5.79	4	191	2009-09-11 13:31:48	2004-11-24 15:59:50	7	1	15	0	0	100	0	200.00	65	81.24	CHANGED	+VLSppGKpt.cKhK.-ILKpLhu.opDhY+FahhPopQ+lhNlslsMccFPpsYILAGPIpNcSITahWFDFYSTQLRKPAKYVYSEYNHTu+KITFRPPSCGTVPSMsCLSEMLNVS+RNsTGEcuCGNFTTFNPMFFNVPRWNTKLYVGSsKVNVDSQTIYFLGLsALLLRYAQRNCTRSFYLVNAMSRNLFRVPKYINGTKLKNTMRKLKRKQAPVKE.spKKSKKSQ.STTTPYSsYTTSTsFNVoTNVTYSsTssspRlsTSTIuYRPDSsFMKSIMTTQLRDLATWVYTTLRYRp-PFC+ssRNRTAVSEFMKNTHVLIRNETPYTIYGTLDMSSLYYNETMsVENETASDNNETTPTSPSTtFQRTFIDPLWDYLDSLLFLscIRNFSLQ.PsYGNLTPPEHRRAVNLSTL	..........................................pVLSphGK.cLcphKlEILKQL...ppDhYphahp.o+QtlpNlThs.MscFPph.Y.ILAGPIpNpSITYLWFDF..YSTQLRK..P.......A.........KYVYSpY.....NHT.A..+pIT.....FRP...PsCGTVPS...............................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+7814	PF07983	X8		X8 domain	Bateman A	anon	Pfam-B_374 (Release 16.0)	Domain	The X8 domain [2] domain contains at least 6 conserved cysteine residues that presumably form three disulphide bridges. The domain is found in an Olive pollen allergen [1] as well as at the C-terminus of several families of glycosyl hydrolases [2]. This domain may be involved in carbohydrate binding. This domain is characteristic of GPI-anchored domains [4,5].	25.70	25.70	26.30	25.70	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.15	0.72	-3.49	189	1389	2009-01-15 18:05:59	2004-11-24 17:27:23	8	20	213	4	865	1350	0	72.40	35	18.91	CHANGED	hhCVs.p.sss.....sspphtshhsasCu......st..s.-CsuI.sssus..........Css......ps+hSashNpYYppp...sp.s.ssuCsFsGsAs	....................WCVsp....s.ss.....spspLpss....lsaACut.........t....uDCss.Ipsuus............Cap.....shts+uSYAhNsYYQpp......sp..s.....sssCsFsGsA.........	0	131	493	696
+7815	PF07984	DUF1693		Domain of unknown function (DUF1693) 	Mistry J	anon	Pfam-B_3630 (release 16.0)	Domain	This family contains many hypothetical proteins.  It also includes four nematode prion-like proteins. This domain has been identified as part of the nucleotidyltransferase superfamily [2].	19.80	19.80	19.90	19.80	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.07	0.70	-5.27	11	296	2012-10-02 22:47:23	2004-11-25 10:17:43	7	7	97	0	182	265	0	287.70	57	67.88	CHANGED	Lsa-QVpRLcslLsEslPIHGRGNFPTL-lp.+plV......................................................psVRu+LE-p......GlpV+DVRLNGSAASHVLspDsGluYKDLDLIFslsLss-ss.......FphlKDVVLssLLDFLPcGVsKEKloshTLKEAYVQKhVKV..ssDsDRWSLISLSNssG.KNVELKFVDSlRRQFEFSVDSFQIhLDSLLhFhcsupsshoEsFaPTVlGEShYGDFpEAhsHLpp+LIATRsPEEIRGGGLLKYCsLLVRsFRPuspp-lKsLERYMCSRFFIDFPDItEQpRKLEuYLpNHF..............hGt-.cs..................KY-YLMpL+cVVsESTVCLMGHERRQTLsLIohL	.......................Lsa-QVpRLcplLsEslPIHG....R....G....NFPTLplp.+pIV......................................................psVRs+Lpcp......GItV+D..VRLNGSAASHVLtp..-s.........G..hu.............YKDLDLIFsl..-..L...s..-tp............FphVK-s.VLssLLDFL....PcG.Vs+cK.......I...os......hTL.KEAYVQKhV.KV....s.sDs.......DRWSLISL...S..Nss...G...KNVELKFVDSlRRQFEFSVDSFQIhL..DSLLhFa......ps....u.....p.....s..Ph.o.-.....s.F....aP..TVl..GEShYGDFpE...AhpHLp.p+lIuTRpP...E...EIRGGGLLKYCpLLVRsF+Ps.s.pt.-............l.K.sLpRYMCSRFFIDFsDls-Q......p+KLEsYLpNHF..................sG.-..pp...........................+YpYLhhL+pVVsE..STVCLMGHERRQTLsLIshL.................................	0	45	59	114
+7816	PF07985	SRR1		SRR1	Wood V, Mistry J	anon	Pfam-B_29119 (release 16.0)	Domain	SRR1 proteins are signalling proteins involved in regulating the  circadian clock in Arabidopsis[1].	20.70	20.70	20.70	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.75	0.72	-4.04	38	284	2009-01-15 18:05:59	2004-11-25 16:25:20	7	8	229	0	197	286	1	58.00	31	18.80	CHANGED	cl.lClGLGshp.........pshsupaQLAhllhlhchh...pl.....splplY..DPlFsps-t...........phlp.slG	......phlChGLGshs................pshsupaQLAhl.lhlh-th.......ph.....................tps...la..DPlFoph-h...........phLppL...........	0	59	96	156
+7817	PF07986	TBCC		Tubulin binding cofactor C	Mistry J	anon	Pfam-B_4111 (release 16.0)	Domain	Members of this family are involved in the folding pathway of tubulins and form a beta helix structure [2].	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.65	0.71	-4.70	52	603	2012-10-02 17:34:32	2004-11-29 14:13:34	7	18	275	4	417	624	21	115.80	23	26.40	CHANGED	spshplpshppCplhl......hsshsslplcsspssplhh.GsVsuSlalcsCpsspllssspQlRh+sspssshalpsso.pPII......EsspslpFus....ashhYstlptphtts.tls..sss.Wsp..ltDF	.............................phhlpphppshlhl...................hsshss....lplcsspss.t.llh..G...............s...V...s...sulalcsCcssp..lh.....l.....u..C..p.....Q.............lRl............+ssps.splaLt......s..s..........o.....pP..II.......Ess....ps...l.pFuP............a.sh..hYstlptphtts....sls......sp..Wsp...................................................	0	171	246	344
+7818	PF07987	DUF1775	Bacterial_GLE1; 	Domain of unkown function (DUF1775)	Mistry J	anon	Pfam-B_12641 (release 16.0)	Domain	Domain found in bacteria with undetermined function. Its structure has been determined and is an immunoglobulin-like fold.	25.00	25.00	27.60	27.50	24.30	23.90	hmmbuild  --amino -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.91	0.71	-4.36	87	551	2009-01-15 18:05:59	2004-11-29 14:53:07	6	4	483	1	162	455	4	130.40	35	57.34	CHANGED	HVol...ps..spAssGuat.phsh+VPpts-st.uTsclcVplPps..ltuspspPtPGWslpspcsshttsh....tt.hspsVsplsWouss....lsss..pascFslps.plP...tsssslsFsshQshscG....ss.cWs-.sts....Gt.-s.cp...............PAPslpls	................................................................HVol...ps....spuss.Guat.phsh+VPsEps.s..uTTKlplplPpG..ltht.ps...pPh...sGWphchpKss................sttlp.plsWpuss.....l.ss..papcFshsu.p.P......pctsplsasshQpYpDG.......slVcWs.........Gptcs..cp................PAPhhpl.h.......................	0	42	102	139
+7819	PF07988	LMSTEN	Wos2;	LMSTEN motif	Wood V, Mistry J, Bateman A	anon	Pfam-B_4851 (release 16.0)	Motif	This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.	19.30	19.30	23.60	26.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.24	0.72	-4.67	6	191	2009-01-15 18:05:59	2004-11-29 16:03:41	7	19	45	2	59	174	0	46.60	72	7.43	CHANGED	csNhlphsQsusAhIQppasD.EDP-KEKRIKELELLLMSTENEl+pKp	..............clNIVNl.PQPuuAAIQRHYsD.EDPEKEKRIKELELLLMSTENEL+GQp..	0	3	7	23
+7820	PF07989	Microtub_assoc	Spindle_assoc; 	Microtubule associated	Mistry J, Wood V	anon	Pfam-B_45034 (release 16.0)	Domain	This presumed domain has been identified in two microtubule associated proteins in Schizosaccharomyces pombe, Mto1 and Pcp1. Mto1 has been identified in association with spindle pole body and non-spindle pole body microtubules [1]. The pericentrin homolog Pcp1 is also associated with the fungal centrosome or spindle pole body (SPB) [2].	21.90	21.90	22.10	22.00	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.40	0.72	-4.15	15	383	2009-09-11 00:31:27	2004-11-29 16:39:38	6	11	174	0	233	391	5	72.10	39	5.41	CHANGED	TLRE.EpplscL+KENFsLKL+IaFLEEplp..pcss-sscclhKpNI-LKlEltoLc+-lpcpcchLpcAp+slcs	.................sh+-.-pp..lscLcKENFsLKLRIaFLEEphp..............pphc.sstcchh+cNlE.LKV-ltoLp+-lpchcchLpcsp+slc.s........................................	0	56	101	170
+7821	PF07990	NABP		Nucleic acid binding protein NABP	Wood V, Mistry J	anon	Pfam-B_10222 (release 16.0)	Domain	Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterised [1] and  contains two putative phosphorylation sites and a possible dimerisation  / leucine zipper domain.	21.60	21.60	21.80	22.40	19.60	21.40	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.51	0.70	-5.19	10	106	2009-01-15 18:05:59	2004-11-30 09:14:21	7	8	21	0	60	101	0	289.90	33	38.22	CHANGED	RVPSPCLsPIGs.RVuusDK+ssuusSsFNssoSulsESuDLluALSGMNLSsouulct.psh.pSQhpQDV-shpsYhFslQGGpspsNQ.Huahp+uDpuah.........................................+usssstsu.hpuspuSshssGuulss.aQp.hDusN.sh......suYulNPAluSMMtNQLGsuNhsPha-NsuAuSuhussuhDSR.hGuuhsSus...tusS-scNLsRlGNph..uGouLQSshsDPMYhQYLphsp.uAsusAshsDPSh-RNah.GoSYMDhLtlQKAYLuuLLt.QKpQYGlPh..KSuusssHuYYGsPuFG..GhuYPGSPLuoPslPsS.huPsSPlR+uEhNMRas...SuhRNh.GGlMGSWHhDs.sshD-sFuSSLLEEFKSNKTRuFELS	.................................................................................................................................RsPust.sPlGs.+h.s.-.K+s.ss....pt.sos.hs-ss-lhsALSshshS...ssthh...st...tt...uph.p.plpp.pph..hhsh.ssppph.pp.pthhppsp....tt................................................................................................................................tsashsss...suhhhs..phs.ssshss..h-s..s..s.....uuuh.u..sthsSt..Gssh.st.....s.sp..shsthus.....usuhQs..hDPhYhQYhp...s.p.sstt.....hus.tDP.htps.ah.Gsuahsh.t.....hQKAalt.shh....t.QK.......Q..at.......s......pts..s.sYaGs..s.a...shsYsGSPls...sshhssS.hussS.PhRcs-h.shRhs...SshRNh.u..GshG........uWp.-h.t.ph-tshssShLEEFKoNKo+saELu.................................	0	8	34	48
+7822	PF07991	IlvN		Acetohydroxy acid isomeroreductase, catalytic domain	Bateman A, Griffiths-Jones SR	anon	Prodom_2380 (release 99.1)	Family	Acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.96	0.71	-4.88	45	4225	2012-10-10 17:06:42	2004-11-30 13:30:19	7	7	3943	20	1058	7052	5249	165.30	49	44.30	CHANGED	lL+s.KplAlIGYGSQGHAHAhNLRDSGl.cVllGLRpGu....t.Shc+AcpcGFcVholsEAscpADllMlLlPDEhQspVYcpcIpPNL+cGs..sLsFuHGFNIHas.IpPPcsVDVhMVAPKGPGHhVRcpYpcGtGVPsLlAVa..QDso.GpAh-lALuYAKGIGusRAG	......................................h.lpGKKVAll.G.Y.G.S.Q..G..HA......aAh...NL..R...D........S.......G.l....-......V...s...l..G.L.R.p..G.u...............t....S.a...c....K..A.......c........p........s........G...........F...............c.................V.......h.....o.........l...s...E..........A....s....p...p...A....D...l...l..M...h...L..h..P...D..c..h..Q..u.c..l.a...t..p...c..lp..Pp..L.+pG.s..AL..u...F.u..H.G........F...N....I...H....a........s....t........l...p........s...........p.D.l....DV...hM.......V.AP.K.u.PGHh..V....RcpYp.....c...G.....t.....GVP..sLlAVa..QDs....o.....G....p.......AhslAluYAtulGGsRAG............................................................................................	0	334	687	899
+7823	PF07992	Pyr_redox_2		Pyridine nucleotide-disulphide oxidoreductase	Finn RD	anon	Manual	Domain	This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null --hand HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.67	0.71	-4.44	139	57441	2012-10-10 17:06:42	2004-11-30 13:43:45	9	725	5624	527	15622	68615	26122	259.00	18	57.57	CHANGED	cllllGuGsAGhsAAhpht......phshc.lsll.............pp.sthsh.stsslspphhhpstthht.h....t.h.....................................pphh...tp.tslch............hht.ppshpl..shspt.......................t..h..........hphcplllATG.up.sth.....sls.G..................t.h.hh.ptltsupphhphhph............................sp...cllllGuGhlGlEhAthhpphGtcVsllcttsphhsth.sphttthhpphh..................................................hththhttttstpttsssphtththsstpphpsDhlllulGhpPsschh.....cphGlch..........tp..................pGhI..hl-c.....th..pT.......................s...ssslaAsGDsstht.	.................................................................................................................................cllllGu......G..s.u...Ghs....sAh.t...hs........................pt.s...h....c....l....s..ll.........................................................pt.....s...............s......h.............h.......s....t....l.....s.....p...t...h...h....h....p..s...h..t.h..h....t.....h..............................................................................................................................................phh.t.t.h..t.......p....hs..h..ph.....................................ht......pp...s...h..pl.........thst.t...........................................................................................................t....t.t....p....h....p.h...c...t...l...l.l....A....s...G....u.......p....s.t.h.....................sls.G..........................................t..t....l.........s...s..t...t...h....h..t.h....h.........................................................................................sp.......pls...l...lGuG.huh-hu.hhtths.pshhh.hht.hh............................................................................................................................................................................................................................................................................h.hh.........tt.t......ttttt..hshhhhhhshhsssp.h....tths.l..p..h..........t.p..........................................................p.G...h...l........h..s......s.p..............h..........p.T......................................................................s......hs..s..laA..hGDsht...t........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	5062	9898	13194
+7824	PF07993	NAD_binding_4		Male sterility protein	Griffiths-Jones SR	anon	Pfam-B_1115 (release 6.4)	Family	This family represents the C-terminal region of the male sterility protein in a number of arabidopsis and drosophila.  A sequence-related jojoba acyl CoA reductase is also included.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.58	0.70	-5.45	102	3739	2012-10-10 17:06:42	2004-11-30 13:44:47	7	268	1310	1	2010	30893	13882	233.90	23	19.78	CHANGED	lTGuTGFLGphllccLL..cssssh..clasL.VR.upssp....sutpRl.pphhphslap.h..............tp+lpslsGDlspsp...LGLsspshppL..sppl-lllHsAAsVpast..shpp..hhssNVhGTtpllcLAp.........p.h+ph......shhaVST........uhssstpt.th.c.....................................................htp.thshhtshss.sYshoKhhAEhllpptt...sLP....l.....sIhRPuhlsu...................................-shs.G..hhsshc.hhphlhhsht.tGhh.shhss.t.............hshlPVDhVspul	...............................................................................................lTGuT.GF.L...Gt.h......l....l.p......cL....L....p................p.......s.......s...................h......pl.....h...s..L.....l.R.....s...p..p......t...t............t...s........h...p...R.....l.......p.t..h....p.h.t..h....tth............................................hp+.l.p..s.l.s..G...D..l...s..p.......p.........L...G......L.............s....p....t...p.....h....p.t...L........h........p.................p......l..s........h.............l..l..H......s...A.........A........t.......l.......s.......a.......s.......t..............s.....h.....p...p.............h....h....t....s......N.....l....t....G....T..t....p....l....l....c....l...At.......................p..hpph..........thha...l..So........uh..s....s..s......t..t......t...h..............................................................................................................................................................................t.p....t......t..h..h...t....s..h.s...s....sY.....s.t...o...Kh..h....u....E.......h....l....l.........p......p.......t......t.......................................s........l....s..................s...................sl..h..R........s.uh.lsu.......................................................ps.h.s..G....h.h..s...s...h...s.......h....t.h...h.h.......h..s..h.t.....h.....s.....h..h...........t...h....h...s.p........................................hshlPVDhssph.......................................................................................................................................................................................................	1	595	1051	1665
+7825	PF07994	NAD_binding_5		Myo-inositol-1-phosphate synthase	Bashton M, Bateman A	anon	Pfam-B_959 (release 4.1)	Family	This is a family of myo-inositol-1-phosphate synthases. Inositol-1-phosphate catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated  to inositol [1]. Inositol phosphates play an important role in  signal transduction.	25.00	25.00	28.60	28.40	20.90	20.70	hmmbuild  -o /dev/null --hand HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.93	0.70	-4.92	37	1323	2012-10-10 17:06:42	2004-11-30 13:45:19	7	12	949	36	547	1220	416	337.10	33	89.86	CHANGED	ltlhlVGhhGNsuoTllsGlhA.+cshshts............G.lsthushclG...............th.PhhsssshVluGaDI...sshplucshpc....Atshs.slpppltschp.....................shlssspup+hDslhs........tstsphcpspphtpDItcFtcpsslD......phllL.susTEp.........h.......shttl.tshp.sttp.lssSphYAhAul..h......tGssalNusPpssh.sP..uhh-hAccpsl..IsGDDhKoGpTth+osLs.hhlttshcspulsoYNhLGNsDGtsLos.pphRSKchoKSsl.ss.............................................p.hhphphsccssHhssIcYlPhlGDsKhAhDchpuclFhGup.plpl+.sscDShlAuPlllDLlhhsclspc.........................................+shtu.Vhsh.SYahKuPh......stthssh.cQttsl-shlR	.................................................................ltlhllGh.GNsuoolhtGl.h.+ps.s.tt..................lsth..php..hG.....................shhs.s..hhuuaDl...ss...h...pl...upsh....tc.....Ahhhp..s.p.pl.t..ph..........................thlssp...ps.p..h.sslht..........................phpt.pt...DlhchhcpsplD........Vll.hssTtp..................................................hssophYAhAul........tsssF.lNu.Pp.hh.sP.......thhchhpc.tsl..IsGDDhKSt.sthhohhs.hhlhtshtsp..hohph.ssssh..Ls..pp.R.cphphSps.s.................................................ts.h..thttcssHhss.cYlshlsDpKhAhschpuphFhss..slphp.ps.DS..uAslllDhlhhsclutc.............................................cuhtu..lhs.h.uahhKuP..........s..hps....pththlcphh...................................................................................................................	0	192	351	473
+7826	PF07995	GSDH		Glucose / Sorbosone dehydrogenase	Mistry J, Bateman A	anon	Pfam-B_1863 (release 16.0)	Domain	Members of this family are glucose/sorbosone dehydrogenases that possess a beta-propeller fold.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.23	0.70	-5.36	164	3525	2012-10-05 17:30:43	2004-11-30 16:29:24	6	176	1857	34	1319	3362	3764	295.30	22	60.71	CHANGED	LcpP...Wul......uFL.P....D.G.ph.LlTER.sGclplls.........sGph..pslsGl........P.pV..........hspG.....QGGLLDlslsPcF..sps........phlYloYu......................tss.....ss.ss...sT.sluRucL..sss.....pLp....shcslact...pPt.hss..stHaGuR.lsFs.....s.....DG.pLalohG-Rtp..........cs......pAQDh...ssphGKllRls.sDGolPsDNPFs........s.........ps..............suts.pIWSYGHRNsQ.GhshcspsGpLWspEHGP+GG......DElNllcsGtNYGWPlloaGhpYs....Gs.................lspt..sspsG.........hppPlh.hWsPo....IAPSGhsaYsG...ct.F.P.p......WcGslhlGuL.p.......sptLhRlpl.c.s...............sp....lsppE+lh.........................tshG.RlRDVppuPD.G.tlYllTD.........tsG...p.........llR	...................................................................................................................................................................h.h.hh.s.......s...t.....t......h.hl....s..p....G.t.lhhht.................ttth..............h.........th...................tl..........................t....s.....p.......t...G....l.h.s..l.s.h....t...P.t....a.....t......p..s.........thh.a.h.hs..........................................................t......ts...tlsph.ph...pts...................p..h...p......s......p....s....l..hp.t...............h.Pt......t..........s.pH...hG.sp...lh.Fs...............s..........-.....G...hLa.l..shG-ssp........................ht..............................tu..ps...h.........p.p......h........t...G...p........l.....l.......R...............l......s.......s...............s...............G..................p............h......s....s......NP.h..............................................................................ts....cl.a..uhGhRNs...............G..huh.......s.......s.......t.......s..........u...p......La...........h..s.....-...h..G......sc.th................................................D...E..l....s...h........l........p......t......G.........t......sY.GW.....Ph..h.t..h....s......p.hs.......................s..........................h.tt.....p.htt.........h......P.....h......h......h.....t.sp.....................u.....s.........G.h...h.....h.h....p...u...........p.........h...s..t.............................ap.tthh....huth..t..................s..plh....hh.h..p.s.........................t............h.h.t....t..hh...............................ttht...R..h....sl....h.......s.....c..G...lhl.ss..............................................................................................................................................................	0	434	842	1113
+7827	PF07996	T4SS		Type IV secretion system proteins	Mistry J	anon	Pfam-B_4497 (release 16.0)	Family	Members of this family  are components of the type IV  secretion system.  They mediate intracellular transfer of macromolecules via a mechanism ancestrally related to that of bacterial conjugation  machineries [1][2].	24.70	24.70	24.80	25.00	24.50	24.60	hmmbuild  --amino -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.17	0.71	-4.45	50	544	2009-01-15 18:05:59	2004-12-01 12:38:11	6	3	398	1	96	471	20	189.20	20	79.43	CHANGED	GIPVhDsus........hhpt....hppltphtpplpp..............hppQlpp.hcp.Ypu....loGscshGslh...sssshppslP.psapslhsth....sshuuluupsptlhpttphhss........tsstppptsptthspsststuhuppsYspsppRlsplppLhppIssspDsKshuDLQsRItsEpshlQs-ps+Lphhphhtpupppltpppppc	.............................................GlPVhDsss..............htph..........hpphtphtpp.lpp.................hppQlpp.hc.......pphpu...............hT.Ghp..sh..sshh.........ps..sh.pphh..s.....ps.hps.l..hssh.......tss.uuhusp.hp.ph.......hp.p..phhs.....................h.spsttptspt.ph....ph...sts.h...s.h..spps.....hppsppchpplppLhpplspsp....D.K..thtDLpsplpsEpshlpsp...php....hph.hpthtps.pp.ph.pppt......................................................................................	0	9	46	67
+7828	PF07997	DUF1694		Protein of unknown function (DUF1694)	Mistry J	anon	Pfam-B_4517 (release 16.0)	Family	This family contains many hypothetical proteins.	25.00	25.00	26.90	32.50	24.60	21.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.25	0.71	-10.41	0.71	-4.17	33	780	2009-01-15 18:05:59	2004-12-01 14:05:26	6	1	736	2	85	413	0	120.90	33	82.58	CHANGED	Mo-p....lccpLppuhaG..ssphcPDE+RpaLGoaRERVllulThsplppppsh..pplpptLpc....hps..hplhlNGplshs.hhspYl+lAsctslpaTlVsspptpo....shGlVls.ucpAlsp-plpl	....................Msc.....lpcpL.cthaG..s.plsPDEQR+YLGTFcERVhltlslspspssplp..pthhphLcs......tps....lplhlssplshs.ttshYlKhApcpssphTIVscpphpo.......shGLllp.uspAVsh-ph-l..............	0	27	50	65
+7829	PF07998	Peptidase_M54	DUF1695; 	Peptidase family M54	Mistry J, Bateman A	anon	Pfam-B_4509 (release 16.0)	Family	This is a family of metallopeptidases.  Two human proteins have been reported to degrade synthetic substrates and peptides [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.41	0.71	-4.54	5	267	2012-10-03 04:41:15	2004-12-01 14:39:37	6	3	198	3	176	401	24	127.40	29	50.09	CHANGED	M-cIAFlYMGGcEacWLFFEVYDRVcRal+DVsLsVslVYAGRIKLPPGhLlRVpstsGalsMYsFEAVVEALYGKLVEM+sDVNDDSlTKIFGITTlPIGSRDpYFDIYKKYLGIpVslGNYsVLuLS..IKPFYTE..N+ELFlERVFKGVLHElGHLYGLSHCss.DCVMNPPsDL+DWD+RuPoYCNsCL+cLKR	.........................................................................................................................................................................................................................................................................h.lh...-ha..........hp..hhhG.....s......thslh.h............h..........................s.t..p..l..h.....h...pRshKps.sHElGHhhGLpHCpp...pClMph.S..so...lp...-sDp+s.p.h.Cs.Chp+Lt......................	1	64	100	138
+7830	PF07999	RHSP		Retrotransposon hot spot protein	Mistry J, Bateman A	anon	Pfam-B_4567 (release 16.0)	Family	Members of this family are retrotransposon hot spot proteins.  They  are associated with polymorphic subtelomeric regions in Trypanosoma. These proteins contain a P-loop motif.	19.50	19.50	19.50	19.60	19.20	19.40	hmmbuild  -o /dev/null HMM SEED	439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.68	0.70	-5.89	3	829	2012-10-05 12:31:09	2004-12-02 10:36:38	6	4	10	0	349	862	1	307.10	29	57.65	CHANGED	YDSIYNA+WuYVMSGaNsEPLGMKVa...DGEPPchWTcEEVsVSHTP-DhsEP..LPR+GNLEIAVLTSQ+GWPashFh..pcllscDAsc.t..DaVFs.DVYIRREVhRVWalVKpRLspWLpS+Lp-+psPs..VLlGTPGIGKShuVGSFLLY+LLHYDAELLpIIAYsV+G.KAYVFaKsTss+sGpVTFYpchssulcAVc-LuR.....EslKGYIIYDVGKchcpPuPhsPPsGWusIVLoSPDhssYhEWucp+RAlRIhINCs-EsDLKAhsl..W+Klups.t.sPo-A+..plEsEWQEIcGRIcKVGPLLRaIl-.-uSYKtplcKIcEAlsEhScsccpSYhpVFssuspWcscKsochLARlVRV+sE.NGEpCcN...sPlSAYluQKhLshLRsWlspAphNcasuRpulRusttHAA.pFEKsGIaAFoplNsltsIs++LRtLP	.............................................a-SlhpApWpaV.h...p...s........s.....t....................h....G.M.tVh.....t...G...p..............p........Wo.tps..s..............s..............p....t.c..s....p......................t........h..h.hVLoSphGWPat............................................t...c....salppE..RVW.lVcttlstW...h......t...t...............s..h..lll.GTPGIGKShusGShLLapLLHap.......st.L........hVsahh.ts.psalh.ptt.t....pV..hY.tt..shp.lpth.t......................tth..c.GalIhDhstt...........s...........s...t.W.uhlllosPp.ppapta...p.p....t..s....l.hhNC.pt.-h+Ahhs...W.......p.h.t...............................................................t.....................................Wp....l....ctR.hp.VGPl.Ralhs..t.t...a.ttchtthtthlt.h........ht..h..hh.......h..pt...p.lhclVp...t................s..........hs...h...........................................................................................................................	0	183	223	349
+7831	PF08000	bPH_1	DUF1696;	Bacterial PH domain	Mistry J, Bakolitsa C, Bateman A	anon	Pfam-B_4657 (release 16.0)	Domain	This family contains many bacterial hypothetical proteins. The structures of Swiss:A1SD03, PDB:3hsa, and Swiss:A3QB43, PDB:3dcx, show similarities to the PH or pleckstrin homology domain. First evidence of PH-like domains in bacteria suggests role in  cell envelope stress response [1].	21.50	21.50	21.50	23.30	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.41	0.71	-4.49	55	796	2012-10-04 00:02:25	2004-12-02 12:40:12	6	3	653	16	178	567	35	123.10	36	88.40	CHANGED	MGlhsulhGsuutl..s.sclpcchsslLl...suEplphuaKllRDhhlFTsKRLIllDpQGlTG+Kl-apSlPY+u..IopFSlETA.GpFDLDuELKI.WlSupshPlp........hphp+stslhclppsLAphlh	............................hhpGlhGsuo.h..ssp.p.hpc.cl.t.clLl...csEpl.hu....aKhl....RD....hhlFTs+RLIllDtQGlTGKKspa+S..l..PY+u..IspaSlET....A....G.p.F.D..L..DuELKI.Wluut.p.hslp.........hpF.cp.spslhslppsLsphh..............................................	0	63	119	152
+7832	PF08001	CMV_US		CMV US	Mistry J	anon	Pfam-B_4698 (release 16.0)	Family	This is a family of unique short (US) cytoplasmic glycoproteins which are expressed in cytomegalovirus [1].	21.50	21.50	22.90	24.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.75	0.70	-5.31	8	91	2009-01-15 18:05:59	2004-12-02 13:34:17	6	1	12	0	0	75	0	218.80	30	93.92	CHANGED	Mpl....hhshlhlsshsAlushpsshcE.uhph...hspssstttsR...........phthPPhP.......pt.pVpSpsupCVlcc.GsLsAlWplRGsF.....hP+....shspatsccocthhcltsPct-lsss.hs..lRa.....pVssclsaVhLplhPCppCppha.cCcPphclPWlPhhoShc.DlcRLaaEpRaLplhaVlhlphhthsLL...shhsApslathplthalR.RHt.hh...........ss.p.hp..tcpt	.....................................................hh.hhhhhshhslsh......-.shph....ppsps.ptpc..........hphpLP.hP........pt.pVsSppupCs.lcs.GsLsAsWplcGs...F.....sP+.....shsphhtccust.hh+V.sPphps-.ss.hs..lRh.....pV.s...sclshVhlplhPC.ptCps.a.cCcPphpl.PWlPh.hsS.hp..DlcRLaaEcRaLphhaslhlphshhsLL...hhhlhpshahhhlt.al+.hph..........................s.........................	0	0	0	0
+7833	PF08002	DUF1697		Protein of unknown function (DUF1697)	Mistry J	anon	Pfam-B_4800 (release 16.0)	Family	This family contains many hypothetical bacterial proteins.	23.30	23.30	23.30	24.20	21.00	23.20	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.13	88	961	2009-01-15 18:05:59	2004-12-02 15:33:07	6	2	861	4	233	734	24	130.00	31	75.33	CHANGED	MspYlALLRGINVGGps+ls.Mu-L+shhpshGassVpTYIpSGNllFp.....sppstsplppplcptlccpaGhsssVllhotpclpplhsssPa..tt...tps....pphhlhFlppshst-.thtpltthpst..Echthss...psl.Y	........MtpYhhLLRGINVGG+N+ls.MA....-L+phL.psl.G.h.ppVc..TYIsSGNllFp.....op.......pstspltpclcshlpppasa.t...hshh.lhohp-hpthlpsh.Ph.hpt........-h.......tchplhFhspshshc.....lt...p.l.ts..h.p....hts..Etlhhspt.h................................	0	76	156	197
+7834	PF08003	Methyltransf_9	DUF1698; 	Protein of unknown function (DUF1698)	Mistry J	anon	Pfam-B_4787 (release 16.0)	Family	This family contains many hypothetical proteins.  It also includes two  putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.89	0.70	-5.73	11	1216	2012-10-10 17:06:42	2004-12-02 16:27:41	6	2	1182	0	199	2993	1047	295.80	54	95.83	CHANGED	FYQpIAp.ssLpcWLpTLPsQLssWp.pppHGcat+Wh+sLcpLPphpP-plDLpsu.VoscpcpslupGEpcc.LcplLRthMPWRKGPaslaGlHIDTEWRSDWKWDRVLPHlSPLpsRolLDVGCGsGYHMWRMlGEGAphsVGIDPopLFLCQFEAVR+LLGsDpRAaLLPLGIEQLPt.LpAFDTVFSMGVLYHRRSPLDHLhQLKsQLVpGGELlLETLVI-GDEssVLVPs-RYAQM+NVYFlPSAtALpsWLcKsGFsDVRlVDpslTos-EQRpT-WMpsESLsDaLDPpDsoKTlEGYPAP+RAlllA+K	...............................................................................................hYp.IAp.s.Lp.WLpoL.PtQlst.Wp...pptH.G.htpW...pslch.LP.p...........l.p..P....p.l.D...L..h.p....u.....Vs.scsppsLo..tG..p..h..cc....lcslh+s..L....hPW..R.K....G...PFp.L.....a..G...................lp......I....D..T...E.W....R.....S..D...W...K..W...D.R.V..L..P...........H......l......S...........s....L......s....G...R...o...lLDVGCG...uG....Y....H...h..W...R.M...l..........G...t...G................A..+..h...s...V.G..I..D......P...o....p.......L........F.............L...s...Q...........F..E..........A....l.R...K.........L..L....G.......s......D.......p...........R.......A..+...L..L...P.....L......G....I...E..Q.....L........P.....s.....L..........p.......A......F..D.T.V...F....S..M.G....V...L..Y..H......R.....R..S..P...L.......-..H....L...h....Q.L....K....s.Q.LV..stGE.L.V......L.........E.......T..........L...V....l-............G......D.......c.....................s......s....V......L.....................V....P....s.....D..............R........Y....A...Q......M.......R.......N.....V.......Y......F......I.P.....S.s.A..LKsW...L...cKsGF.h..D..l..Rl.lD...s.s...l....T....os...-....E.QR.+..T..-WM..s..sc.SLsDF...LD...PpD.oKTlEGYPAPpRAlllApK...........................................................................................................	0	46	104	155
+7835	PF08004	DUF1699		Protein of unknown function (DUF1699)	Mistry J	anon	Pfam-B_4896 (release 16.0)	Family	This family contains many archaeal proteins which have very conserved sequences.  	29.20	29.20	30.40	30.30	28.60	29.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.56	0.71	-4.62	13	59	2009-01-15 18:05:59	2004-12-02 16:44:29	6	1	11	0	59	60	0	127.60	53	95.70	CHANGED	MKIRVVSSR-EItsLNsNE+lVHLAFRPSN+DlFpLVcoCP+lElIQlPpSYh+TlSKSIcMFLEMQpIpLlEGDVWGHRKDINEYYsVspsVI-+IpEh+sEGhSsEcIsEKls+EoKLuP-MltYILsp	.........M+IRVVSS+-EI.sLNsNE+lVHLAFRPSNpDlFsLVcpCPclcslQlPpSYh+TlS+SIcMFL-MQtIpL.lEGDVWGHRKDINEYYplspsll-+Ic-L+s-GhosE-ItcKls+EoKLsP-hltYIlp.p............	0	12	35	40
+7836	PF08005	PHR		PHR domain 	Stogios PJ, Finn RD, Mistry J	anon	Stogios PJ	Domain	This domain is called PHR as it was original found in the proteins PAM (Swiss:O75592), highwire (Swiss:Q9NB71) and RPM (Swiss:Q17551) [1].  This domain can be duplicated in the highwire, PFAM and PRM sequence.\	     The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [2].	20.80	20.80	21.00	21.20	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.94	0.71	-4.05	18	549	2009-01-15 18:05:59	2004-12-02 17:17:51	7	40	122	5	326	477	0	142.80	41	14.32	CHANGED	sRFpps...uspWsauup.sDuIpFsVD+c.IhlsGhGLYG.....up...u-YpsplcLh.......................................pcpsclLupscssa.s-u.ssssaclhFccPVplpsshhYsspAplpGsc.SthGssGhppVpssc.......VsFpFpsustusNGTsVpsGQIPEllaYs	............................pRFpps...uspWtYpGp..sDuIp.....F.....uVD+c..IhlsGhG........LYG............ut......u-YpscIclh.........................................................................................cpsssLupspsta...hsDu....suss..atlh..FccPVplpssshYsAs.s.h...l...pG.s.c...Sh.hGpcGhspVpsss.............VsFp...Fp....s.u.st.Ss....N.GTsVps.GQIPpllaY..................................................	0	93	117	219
+7837	PF08006	DUF1700		Protein of unknown function (DUF1700)	Mistry J	anon	Pfam-B_5023 (release 16.0)	Family	This family contains many hypothetical bacterial proteins and two putative membrane proteins (Swiss:Q6GFD0 and Swiss:Q6G806). 	28.30	28.30	28.50	28.50	28.20	28.10	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.97	0.71	-4.98	18	1443	2012-10-01 22:34:14	2004-12-06 14:55:25	6	16	1095	0	127	829	10	161.70	25	81.69	CHANGED	MsKppFLpcLcppLcplPccE+c-ILt-YEpHFh.GtpcGKoEcEIhccLGsP+pIAKElpAp.sIccs...........cppsohpNlh+AlhuslGLulhNhhlllhPhlhllsl...llulhlsuhsh......lhuPllLlhtulhsGhhphhhs..........lFhuIshsGlGlllsllsahlsKhha+Lhl+YL+WNlpllKG	.............................................................Ms+pcaLppLcthL..c.p..L.Pcp.-.p.p-h.hp.YccaFtp.t.t....pG.sE...p-lltpLGsPcp.lAcE.l........h..u...p.....h..t..l.p.pt.....................................p.t..p.....s........p.......p.........h..............p....s..l............h........s....h.........l......u......L.....s.....l...............h..s.............h....h.....h.....l.....h..h..h.....h..h.hh.hh................ll.u.hh.h..h..sh.h.h..............l..h.s.s...h...h.h....l........h..t...s...h...h...h...hh......................lh....h.....u....l..h...h....h..u....hu..h..hhh...h...h..h.............h....hhchh.hhhhhth...h.a......................................................................................................................................	0	46	82	107
+7838	PF08007	Cupin_4	DUF1701; 	Cupin superfamily protein	Mistry J, Bateman A	anon	Pfam-B_5011 (release 16.0)	Family	This family contains many hypothetical proteins that belong to the cupin superfamily.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.29	0.70	-5.19	26	1723	2012-10-10 13:59:34	2004-12-06 16:31:36	7	28	1356	7	547	2097	365	287.10	32	65.62	CHANGED	scpFLccaWp+KPLLI+puhs.....thts.hsss-.LttLupccclsu....Rll...spctspWpsppGPhpp......apphspptWoLLlQulspat.sstpLhpsFcFlPp.WRlDDlMlSa..........ussuG..GVGPHaDpYDVFllQspG++RW+lsp......pss.tphtsc.slphls.h..cshh.DhlLcPGDlLYlPsGhsHpGhu.s..pslsaSlG.hRsPsht-l...............................hsphs-hLhpph.sh...................tthpcst.psh.pssstltss.th.stltthlppllp..sssphtphhsphlsps..phph-.lh...s.h...................ptss...ltphh.csGshL.+pssh+	.............................................................................................................................................h..pFlcc.a.W.Q.K.+.Pl.l........l...+..............p.u.hs..........sa.h....s..s......l.....o.s--.....L.....s.s.L...Ah-p.-lco..................RLl.......sp.p......s.s...p.....W.....p...s.p.pG.P.h...p..p.....................asp.L.s....c.....p.....s....W.o.........LL.VQ.ul..spa.........t.s.s...........t......t.Lh.psFc.....h..lPs..WR.lDDlMlSa..................usP...........GG.....GV...G..P.HhD..p........Y..D...V..F...............l.l..Q......upG.+.RR......WRlGp..................................ph.p....p.p.h......p.....s.....p.......s.....s.l....h.......l.c.....sa...............-s.lh.....D........................L.E.......PGD..lLYlPPGasH.pG..huh-.........suh..saS...l...G....a..R..u...P...s...s..p..-..L....................................................l.s..shs.-a..lhppthst...................thapD.s....t...h....st....tp....s.u....pl....s...p....th...sp....l.....p..phhhph.lp....ps.p.p.h..p.p.ahG.phlops..+hphc......lh......h.....................p.tc......l.phh.tpG..l.t.....................................................................................................................................................	0	189	314	431
+7839	PF08008	Viral_cys_rich		Viral cysteine rich	Mistry J	anon	Pfam-B_4965 (release 16.0)	Domain	Members of this family are polydna viral proteins that contain a cysteine rich motif [1].  Some members of this family have  multiple copies of this domain.	25.00	25.00	27.00	27.00	23.70	22.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.05	0.72	-4.41	15	41	2009-01-15 18:05:59	2004-12-06 17:12:16	7	4	10	2	0	37	0	80.50	32	56.19	CHANGED	phcPsCIs..NacsChtosKPCC.ctpp.opGthsscEalCtcFsuGlCpPlpsIpNlphahELlccLN-TNFpELcppYap.sltpsts	..............t..pssCIs..shp.C..h..pos+PCC.p.pt.p.sphhsc-alChh.FGpG......lCpPlpslpNlphahpLhcplNpTNatELptpYht.sl....p.......	0	0	0	0
+7840	PF08009	CDP-OH_P_tran_2	TOM13; 	CDP-alcohol phosphatidyltransferase 2	Mistry J	anon	Pfam-B_51131 (release 16.0)	Domain	This domain is found on CDP-alcohol phosphatidyltransferases. These enzymes catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.	21.50	21.50	21.50	21.90	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.10	0.72	-4.22	14	224	2009-01-15 18:05:59	2004-12-07 09:29:33	6	2	222	0	63	151	42	38.20	40	13.83	CHANGED	Pc.LlLslhlhlslhhAhLIshPWhsLolhullYlholP	........lVlPlllhVslhlAhLlsaPWhoLulsulhYlh.LP	0	16	34	43
+7841	PF08010	Phage_30_3		Bacteriophage protein GP30.3	Mistry J	anon	Pfam-B_5273 (release 16.0)	Family	Proteins in this family are bacteriophage GP30.3 proteins.  Their  function is poorly characterised [1][2].	28.20	28.20	28.90	52.80	27.30	28.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.69	0.71	-4.71	5	72	2009-09-13 17:33:30	2004-12-07 14:05:45	6	1	71	0	3	50	3	149.50	59	98.28	CHANGED	M...DI+SGuuYPSCALSNFAPHsFVhDGVcCASMEGFLQSLKFKNPEMQc+VCuLVGKAAKF+GpKKsWaRsQ...TLYW+GlPhpRpS-AYQpLl-NAYsElu.QNcGFR+ALpAT+sooLTHSMG+s.KpsETVLTEpEFlssLsRLRDpL	.......MSEL.EIRSNF.pWPSCA..LSNFApWPFVMDGIQFGGLEGFLQGCKVKNVE.QQR.RIFGL.SGL.AAQQ...sG..Ru..YARAQD...RGTLFWLGlPFSRYSsAWKELYTNAYFEAAlQN+GFRDALpASKGKlLKH.SMASuLTKcDTILTEuEFIDlLNhLRDpL....	0	0	3	3
+7842	PF08011	DUF1703		Protein of unknown function (DUF1703)	Mistry J	anon	Pfam-B_5377 (release 16.0)	Family	This family contains many hypothetical bacterial proteins.  It has been identified as a member of the PD-(D/E)XK nuclease superfamily through transitive meta profile searches [1]. DUF1703 has the predicted secondary structure pattern of the restriction endonuclease-like fold core and contains an additional beta-strand at the C-terminus [1].	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.37	0.72	-4.30	45	1376	2012-10-11 20:44:44	2004-12-07 14:49:26	6	10	264	0	217	1284	64	98.50	27	20.59	CHANGED	thEsaYpsllYuahu...shsaplhsEsposcGRhDlhlp.......s.tshhalhEFK....tt.pptssp........cuLpQI+c+uYuppapsps...cplhplGlsFsscpcslhph	.........................t.tEtaYpshh.hshht....hh..sa..hlpsEhcoupG.R........hDlhlp...........p...pch...sa...l.hEhK..............h..pts.sc....................cAlpQI.ccKpYstthptps..........pplhtlGl.sFsscptpl.........................................................	0	109	189	212
+7843	PF08012	DUF1702		Protein of unknown function (DUF1702)	Mistry J	anon	Pfam-B_5312 (release 16.0)	Family	This family of proteins contains many bacterial proteins that are encoded by the UnbL gene.\	   The function of these proteins is unknown.	25.00	25.00	123.50	123.20	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.93	0.70	-5.81	23	78	2009-01-15 18:05:59	2004-12-07 14:53:09	6	1	51	0	27	85	2	312.60	42	96.17	CHANGED	Ms.shtslRRRlLTPsls....-TphssRGF+hKsssA+cpLEoVGpsFLpGYuaAlEARsss-scptLEplPschRGFAYEGAuMuhulLDuLsssuttR..........lsshLAGc.GstHsYMlaVGlGWAMARLP.RhhWssltss......DPLLRWLsLDGYGFHQAYF+TsRYVcpppRcpsasW..s.spscYssRAlDQGIGRALWFVsGoDP-hVAshlcpFPtsR+uDLauGlGLAATYAGGusssELptLtctAGtaRssLAQGuAFAAEARh+AGhlssHTclAsplLC.GhosppAAslspcsRsssss.sGshPA.YEsWRpcIAsphss	..................httlR+hlLsPsls....psphstRGF........phcss.su.pcpLEslGpsFlpGataAl-up.s.s-spppL-t.ls.schRGFAYEGAuMuhslhDuLss.s..ptpR..........htshLsGt......GptHsYhsYVGlGWAMARLP....RhhWtclhss...................cPLL+WLslDGYGFHpAYF+Ts+aVcppttss.asW.t..s.ssYssRAlDQGIGRALWFltGsDsstVushlppFsssR+uDLauGlGLAATYAGGssts.-LptLtctAGpa..pspLAQGuAFAAcARh+AGhlssHTclAsplLC..GhosppAAplsc-stss....sss.....su.shPA.YEhWRpcItsph.s...	0	11	19	24
+7844	PF08013	Tagatose_6_P_K		Tagatose 6 phosphate kinase	Mistry J	anon	Pfam-B_5149 (release 16.0)	Family	Proteins in this family are tagatose 6 phosphate kinases. 	25.00	25.00	25.00	25.60	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	424	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.49	0.70	-6.04	31	1086	2012-10-03 05:58:16	2004-12-07 16:20:22	6	5	720	5	98	655	63	386.40	57	96.98	CHANGED	Mps..L..sLlpp+KsGcshGIhSVCSAHPLVlEAAlcpAhpss.ssVLIEATuNQVNQhGGYTGMTPuDF+caVhplAcchGaPp-+llLGGDHLGPNsWpchPA-pAMspA-sLIpAYVtAGFpKIHLDsSMuCAsDP..ssLsDphlAcRAARLsplAEps....h.pphGtpsslYVIGTEVPlPGG..AtEsLs..plpVTsspAAtpTlpsH+pAFtptGL.ppsasRVIulVVQPGVEFcHpsVlcYcsppApsLophlcs.PthVFEAHSTDYQospAhppLVcDHFAILKVGPuLTFALREALFALstIEsELl...sstppusLtpshEplMhcpPp.WppaYpGssspt+ltR+YShSDRIRYYWscPclpsAlcpLhsNLsspslPLsLlSQYLPtQapulppGcLsscPcsLllc+IpplLpsYttACps	.......................................hppllt.pHKAG.c........phGIhuVCSAH.PLVlEAAlpaspssp.p.lLIEATSNQVsQ..F...G.GYT.G.M.TPADFRpFVhplADplsFsp-.tlILGGDHLGP.....Np.....W.....Q.....p.......sA.s.....tA.Mtpus-LlKuYVtAGFpKIHLDsSMSC.t-DP....lPLs..s-..hV..AE..RAAhLs.....tsAEps.....s...pch.....tc..t.....pLsYV.IGTEVPVPGG..........tt.......ps............lp..p..ltlTps-sAtsTLcsHp+AFttpGL.sthhsRlIAlVVQPGV.EF.DHoslIcYQPtcApALuphl-.pht..hlaEAHSTDYQT.puhppLVtDHFAILKVGPALTFA.............LREAlFuLAtIEpELl.....ss...c...t...p...StlhpVlEcVMLc..cPpYWppaY+ss...h...ssphL......s.........h....t....YS...hS....DRl.....R........YY.WPcspIcsuhtpLhtNLt.sssIPL.slISQYLPhQa....+lppGcL...p...s...tP+pLIhs+I.DlLttY+huCt.t....................................................................................................................................	0	21	45	68
+7845	PF08014	DUF1704		Domain of unknown function (DUF1704)	Mistry J	anon	Pfam-B_5490 (release 16.0)	Domain	This family contains many hypothetical proteins.	21.80	21.80	22.80	22.10	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	349	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.88	0.70	-5.42	35	415	2009-09-10 23:48:06	2004-12-07 16:57:52	6	2	337	0	154	362	93	328.70	31	67.85	CHANGED	+ccFhpsphphtPpapY+.......LshDstph+cpLasl.l-plcD....sslppLacchhcphsthlchLpshGo..ccFhatSlclYGsPscphhssAchlLchs.............thtcppscphsAppAschhppphcpa.....thpscVplSsslsAcAhVuusp...lhlspsshFScp-lpsLtpHElGVHllTTlNGppQP.L+hLShGhPssTtTQEGLAlluEahoGuhohpRL+pLAhRVlAl-thhcGtsFh-sFphLpcphshscccAFslTtRVaRGGG......FTKDhlYL+Ghhclhshh+p.hss.....ls.LhsGKhulcclsllp-LhpcGlLssPcalP.........hhps.sshsshhsa..hlsslc	.......................................................................................................................ptF.tt..p.....Pththt.......hshss.t...hptph.tl.hch.pp..........ssltphhtp.hppht.hhphLp..sh........Gp...tFh..S.phYG..t.sscthhtss.hlhphs........................t..ppc.phhsuppsh..p..hh.pphppah........h..phpVpho-sllucA..h..suusp......lplss.....psh.ascp-lpsLhpHEhhVHlhTslNG.....ptQP..h...p....h....h....u....hG.......h.........Psss.....sTQEGLA.lLtE.h.l.s.t.s....hpRh+pL....shRVhA.ls.hh......pttsFhplFphlpcp.....sh................stpsuashssRVaRGussp.........s.sFTKDhlYLcGhlpllpahpp..hpp................hshL.h.sGKsohcDlchlcp..LsppGhltsP+ah.........thhc.hptLpshhpa..hht...p...........................................	0	31	54	100
+7846	PF08015	Pheromone		Fungal mating-type pheromone	Lee SC	anon	Bateman A	Family	This family corresponds to mating-type pheromone proteins. The homobasidiomycetes, or mushroom fungi, have arguably the most complex mating system of all known organisms. Many species possess a mating system known as bifactorial incompatibility, where two unlinked loci control the mating -type of an individual incompatibility loci (the A and  B mating-type loci). Each A mating-type sublocus encodes a pair of divergently transcribed homeodomain transcription  factors while the genes responsible for B mating-type  activity encode lipopeptide pheromones and G-protein -coupled pheromone receptors [1].	21.80	21.80	21.90	23.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.50	0.72	-3.15	38	68	2009-01-15 18:05:59	2004-12-08 15:46:22	6	1	9	0	20	59	0	61.10	24	97.63	CHANGED	MDs..Fss.lshh.........................................h.ssts.......sssstsssphpshssDtERhssG...shsuaCVl	.............MDs..Fso.lshh.................................t......tssss.s.......sssstssssh.slPsstE+hsuu...shsuaCVI........	0	18	20	20
+7847	PF08016	PKD_channel		Polycystin cation channel	Bateman A	anon	Bateman A	Family	This family contains the cation channel region of PKD1 and PKD2 proteins.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.31	0.70	-6.06	13	1249	2012-10-03 11:11:44	2004-12-08 17:04:05	7	121	184	0	812	4460	432	268.20	19	25.62	CHANGED	shuhtslsphpslapahppsLlstl.....puspo.tt.stp....pshlLGsPRLRQlRlcss...hhh.c.hhpphht....Cpsshu.sspDp..a...W....cthspsssthhhYps...........sspL..............shtpaGhlssYs.ouGYhh..Ls.tstppotctlstLpcppWLDppTRAlFl-aohYNsssNLFssloLlhEhPssGsslsshplcohsLhcassshsh.lhlh.llallhhlaashsEhhpltpct.hpYl+.osWNhL-hsllslsslsslltlhRphhssphhpphh.ssstsFhsFcpluphsphhpsltAhLlFLshlKlh+hlpFspshplhopTLpcuhc-lhuhulhlsllhlAYuthuhLlhGophssasshscuhlol.....hphlsssFsas......th.pss+hLGsLhasshhhlhhalLLNlFlulIp-sYspl	......................................................................................................................................s......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h...t....h......h..u.....h...h...h.....h....h...h.l.....p....h...h...c...h.l......p...h.......t...p...h......s.......h....h...s......l...p.t...s...h....p...l..h...t.F.h.h..hh..h..ll..h.....hu.a...s..................h..u.....h..........l....l............h...........G...............s..............................h.............................p...............a...............p.............s.....h...p...s.h.....sh..........................ht.h...h.........u....s.............a.t..............................................th.......t.......h...t...............h....h.....u...........l...h.....h..hsa....h....h.h.h....h....h.....hl.ls.hhlull.tsapt..............................................................	1	330	402	599
+7848	PF08017	Fibrinogen_BP		Fibrinogen binding protein 	Mistry J	anon	Pfam-B_4323 (release 16.0)	Domain	Proteins in this family bind to fibrinogen.  Members of this family includes the fibrinogen receptor, FbsA, (Swiss:Q8GIU3) which  mediates platelet aggregation [1].	27.30	27.30	27.40	27.80	26.90	27.20	hmmbuild  -o /dev/null HMM SEED	393	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.92	0.70	-13.56	0.70	-6.26	4	85	2009-01-15 18:05:59	2004-12-09 16:47:47	6	15	47	0	45	87	8	228.40	17	25.45	CHANGED	YMGVLGSTIILGSSPVSAMDSVGNQSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAEN+SQGNVLERRQRDAENRSQGNVLERRQRDsEN+SQGNVLERRQRDsENKSQGNVLERRQRDAENRSQGNVLERRQRDAEN+SQGNVLERRQRDAENRSQGNVLERRQRDsENKSQGNVLERRQRDsEN+SQGNVLERRQRDAENRSQGNVLERRQRDsEN+SQGNVLERRQRDsENKSQGNVLERRQRDAENRSQGNVLERRQRDsEN+SQG................................NVLERRQRDAENKSQVGQLIGKNPLLSKSIISRENNHSSQGDSNKQSFSKKVSQVTNVANRPMLTNNSRTISVINKLPKTGDDQNVIFKLVGFGLILLTSRCGLRRNEN	............................................................................................................................................th.tt.p..tph.....tp..t.ptphttpt....ptph.t+tp.tph.p.t....cs..p....tph.....t.+tptphtt....+tptph......t.+t...ptphttc.s...pt..ph.t+tpp..phptps.......pt........ph.t+tpppspt+sp....tps..t+tpppstppsptp....s.t+tptps.t................ptptph.tptptphttptptph......tptptph.tptpt........ph.tptptth.t.pt...tth....p.th....ptth.....ptth..............................................................................................................................................................................................................................................................................	0	16	19	38
+7849	PF08018	Antimicrobial_1		Frog antimicrobial peptide 	Lee SC	anon	Bateman A	Family	This family includes antimicrobial peptides secreted from skins of frogs. The secretion of antimicrobial peptides from the skins of frogs plays an important role in the self defense of these frogs. Structural characterization of these peptides showed that they belonged to four known families: the brevinin-1 family, the esculentin-2 family, the ranatuerin-2 family and the temporin family [1].	21.20	21.20	21.30	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.51	0.72	-6.65	0.72	-4.04	26	221	2009-01-15 18:05:59	2004-12-09 17:23:23	6	3	48	0	1	216	0	23.70	54	39.09	CHANGED	FLPhlhulAAphlPplhCsIoKKC	.....FLPhlAulAAphlP+laCtIoKKC...	0	1	1	1
+7850	PF08019	DUF1705		Domain of unknown function (DUF1705)	Mistry J	anon	Pfam-B_1101 (release 16.0)	Domain	Some members of this family are putative bacterial membrane proteins. This domain is found immediately N terminal to the sulfatase domain in many sulfatases.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.62	0.71	-4.72	114	2318	2009-01-15 18:05:59	2004-12-10 10:47:59	7	4	1307	0	257	1329	103	149.40	26	27.51	CHANGED	hlhshhshl...hslhuhtalhKPlhhllllhuAhssYah.sYGllhDpsMlpNlhpTssuEAtsllohphllalllhGllP.uhllhplcl...phpshh+tlht+hh....hhlsulhllsslshhhapsauSlhRNp+.pl+thlsPsshlhushpahppphhpp	...............................................l.hh.hh.hl...ls.Lhu.h...hhhh+..hl....u.sl...l....l....l....h....SA...uA....p.Y....ah....h....hY....G.ll...Ispuh.ltslhp.TsssE.upp....ll.o.........ph....lLhllh..hul..L...s.sll..l.hhs+l......phs....h..h....+....s....h..h...h...+...lt.......shll...s.lll...lhhh...s...h....h.....psatthhcs.t..ph.......h..h.P.p.lhu.hphh.......t....................................................	1	40	114	185
+7851	PF08020	DUF1706		Protein of unknown function (DUF1706)   	Mistry J	anon	Pfam-B_5540 (release 16.0)	Family	This family contains many hypothetical proteins from bacteria  and yeast.	20.60	20.60	20.90	20.80	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.92	0.71	-4.75	42	927	2012-10-02 14:44:17	2004-12-10 11:49:08	6	4	794	0	99	520	21	149.80	35	96.98	CHANGED	M.spspoKp-LltslppsapKlhs.hsslPcchpppth..t..........ts-+osp-hluYLlGWtpLlLpWhppp..ppGhtVthPspsYKWNpLGtLsppFaccYpph.shpchhthLppshpclhpLI-shSs-ELFsts.htWs......upWslG+alphNTsSPacshppKlR....+apKt	.............Mtp.psKpELhtthppsapKhht.hsslscp..tpp.h...............phD+s.t-slsa.htWppL.lLpW.p..sp....ppGh.ps.hPs..ptapW...pp...hGtL.p.Fhppatph.olpphhthLppshpplhthI-shSp-ELFp..phhtWs......ushslhpahh.sTsu.ashhtpKlR+apK.h.....................	1	33	66	80
+7852	PF08021	FAD_binding_9		Siderophore-interacting FAD-binding domain	Finn RD	anon	Manual	Domain	\N	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.45	0.71	-4.13	40	1962	2012-10-03 00:38:56	2004-12-10 14:18:49	6	12	1325	1	503	1509	90	109.60	34	37.53	CHANGED	pVhpspcloPphtRlshsG.ssLssas..ss.ssDpalKLhFPpsuts.s.h.......ths.th........tt.+PhhRsYTlRphDssst....El-lDFVlH...ss........GPAusWAtpApsGDpltlsG.P.tush	..............................................pVhcspplosphhRlsls.G.....p......s......Lss.Fs...........st..shDs.al.KlhF...Pp...sssph...................h..st....t...hh....h.......stt.+Ps.RsYTsRth..Dt..t..tt...........ElslDFsl.H.....ss............................GsAusW.A.tp.Aps.GDplslsG.Ptut.h.............................	1	122	319	431
+7853	PF08022	FAD_binding_8		FAD-binding domain	Finn RD	anon	Pfam-B_728 (release 4.2)	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.67	0.72	-4.16	19	2729	2012-10-03 00:38:56	2004-12-10 14:19:05	7	89	751	1	1659	2722	95	111.30	22	16.74	CHANGED	hhssph.hpltlhs......ssllplphsKPpt....a+apsGpahalph..slo......phHPFoI.sSust........s-tlslhI+spusaTcpLpphhtp...............................................sthsph.+lhl-GPYGssu	........................................ht.......ph..hhs......ss.s..h.c..l.ph..p..p.sp.................hpacs...G.Qal..a.....lph...s..........s.........lu.....................p...........H.......PFT.l......s.S.s..s.p...................................p..s....t..l...sl....h..l..+s........h....G..s..a....Tpp.Lhphh...t.tt................................................................................................................................pl....hl-GPaGt..s.....................................................................................................................................................................	0	436	875	1356
+7854	PF08023	Antimicrobial_2		Frog antimicrobial peptide 	Lee SC	anon	Bateman A	Family	This family consists of the major classes of antimicrobial peptides secreted from the skin of frogs that  protect the frogs against invading microbes. They are typically between 10-50 amino acids long and are derived from proteolytic cleavage of larger precursors. Major classes of peptides such  esculentin, gaegurin, brevinin, rugosin and ranatuerin are included in this family [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.33	0.72	-3.63	18	473	2009-01-15 18:05:59	2004-12-10 16:58:22	7	2	54	1	0	469	0	32.20	38	49.17	CHANGED	GlLsslKthAKssu....KslApshLsplsCKlotpC	..........GlhsslKshu....tssu....Kss....utslLcpluCKloppC...	0	0	0	0
+7855	PF08024	Antimicrobial_4		Ant antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the ponericin family of antimicrobial peptides isolated from predatory ant Pachycondyla goeldii. The ponericin peptides may adopt amphipathic alpha-helical structure in polar environments. In the ant colony, these peptides exhibit a defensive role against microbial pathogens  arising from prey introduction and/or ingestion [1].	25.00	25.00	26.90	34.40	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.60	0.72	-6.65	0.72	-4.06	5	7	2009-01-15 18:05:59	2004-12-15 11:27:15	6	1	3	0	0	7	0	23.40	51	94.80	CHANGED	WGoLlKhGlKLlPSVVGhFpKKKQ	WGohhKhuhKLlPuVlGhh.KKKp.	0	0	0	0
+7856	PF08025	Antimicrobial_3		Spider antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family includes antimicrobial peptides isolated from the crude venom of the wolf spider Oxyopes kitabensis. These peptides, known as oxyopinins, are the largest linear cationic amphipathic peptides chemically characterised and exhibit disrupting activities towards biological membranes [1].	25.00	25.00	88.20	88.10	19.50	15.60	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.69	0.72	-4.23	2	4	2009-01-15 18:05:59	2004-12-15 11:46:53	6	1	1	0	0	4	0	37.00	84	100.00	CHANGED	GKhSshuKlLRuIAKhFKGVGKsRKQFKpASDLDKNQ	GKFSsFuKILRSIAKhFKGVGKVRKQFKpASDLDKNQ	0	0	0	0
+7857	PF08026	Antimicrobial_5		Bee antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family consists of antimicrobial peptides produced by bees. These peptides have strong antimicrobial and some anti-fungal activity and has homology to abaecin which is the largest proline-rich antimicrobial peptide isolated from European bumblebee Bombus pascuorum [1].	25.00	25.00	28.50	27.90	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.20	0.72	-4.10	2	26	2009-01-15 18:05:59	2004-12-15 11:48:51	6	1	20	0	4	21	0	33.30	73	63.28	CHANGED	aVPh.NsPpPGp.+PFPoFPGpGPFNPKIpWP......Ga	.....Pl.psP.PGt.KPFPTFPGQGPaNPKI+hP..........	0	1	1	4
+7858	PF08027	Albumin_I		Albumin I	Finn RD	anon	Pfam-B_100627 (release 16.0)	Domain	The albumin I protein, a hormone-like peptide, stimulates kinase activity upon binding a membrane bound 43 kDa receptor. The structure of this domain reveals a knottin like fold, comprise of three beta strands [1].	20.20	20.20	23.00	22.70	18.20	17.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-11.06	0.71	-4.37	4	79	2012-10-01 22:06:18	2004-12-16 13:53:21	6	3	23	2	3	89	0	96.10	46	81.40	CHANGED	LsVFLlAshoL.hFspK.luAsDCsGsCSPFEMPPCtSSsCRCIPlGLlsGaChpPSu.solhKMV-EHPNLCQScADCpKKGSGsFCARYPNPDIEYGWCFuSsSEA.-VFhpl...P..RshhK	.................hhlhh..h.h..hp.htA..Cs.s..h...Cosat..h.s.sCt.o.s..s.....CR.C..lPh....sL.h.......sGh.Ch.Po.u....shsKhl-EHPNLCQScs-ChKKGSGNFCARYPNs.lcaGWCFtu.u-u..................................	0	0	3	3
+7859	PF08028	Acyl-CoA_dh_2		Acyl-CoA dehydrogenase, C-terminal domain	Finn RD	anon	Pfam-B_8101 (release 16.0)	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.40	0.71	-10.41	0.71	-3.91	37	2598	2012-10-01 23:33:27	2004-12-17 10:14:48	6	16	1047	24	864	19514	7084	132.50	23	33.66	CHANGED	lshuussLGhA+uALssah-hsp.sRhp.....hsssths-pshsthplAcussclcAAchhl.csspt........scsGpth.s.t.pscspts....puhAschshsussplhpsuGupuhhpssPlQRhaRDl+ssssHshhs.	........................................................................................h..hsushl..Gl...A...cu...A......hc...t.......sh.p...hs....p..p+sp.............tusst..p..h...s....c....c..P......h..............s..........tp..l..G...c......h.......p.s...p.l...p....u....A...cs...h...l...h...p..s.u..c...t...h..p.t.h...................ht.p...s...p..t.....h......s..........t......t...p.....s......p..s..p..hs.............................ps.h..ss.chu....lp.s........s....s.p....l....ac.....h..sG.up.u.h.t.......t.......s..........p..........s...L...pRa......aRss+sh..Hs....s.............................................	0	165	466	687
+7860	PF08029	HisG_C		HisG, C-terminal domain	Finn RD	anon	Pfam-B_1550 (release 16.0)	Domain	\N	22.80	22.80	22.90	27.60	21.60	22.10	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.30	0.72	-4.04	39	1973	2012-10-01 21:59:08	2004-12-17 12:10:15	6	7	1931	6	566	1247	328	75.80	44	25.62	CHANGED	tApphhhlhhNsPpspL-clht......lhPGhcuPTlosL.....scp..salAVpshlsccplhclhscL+plGApsIlVhsIpph	..................pA+cp+hlhhcsPp-+L-clhu.........lLPGhEsPTlhPL.............u-p.....phVAl+hVssEshha-sM-cLKslGApuILVhPIEKh......	0	177	364	489
+7861	PF08030	NAD_binding_6		Ferric reductase NAD binding domain	Finn RD	anon	Manual	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null --hand HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.09	0.71	-4.32	21	2341	2012-10-02 19:13:12	2004-12-17 14:53:52	7	96	341	1	1603	3081	161	162.10	21	23.27	CHANGED	a-sllLluuGhGloshlSllp-lhpp.p..................................hctpphpFhWlsRc.uslchact.h..sEltphcpp.....plclcsYhTu.hps...............ssspsthhp......hpshp.......................................................................pthps......ht.........................sphphu.RPNhcpllpch.........tpsssplGVhsC....Gssshsccl+phss	..................................................................................................................................................................................................................................acsslLlu..uGhGlTshhullp...s..lh..pphp..............................................................................................tt.t..h.t.h.c..+..lh....h.lW.lsR.....c.tp..p.h....c.W.h.........t..s..h.h...........pplt..p.........tpp...............thl.p...l.p..h.....a..l..Tp......pp..................................................................tsh.ps.........................t.....................................................................................................................................................................................................p.........t...p.......................................................hph.ph.G..R.P.sh..pp.h.h.pph....................................t...p.......t...t....p....l..uV...hhC....GP.shspplcphs.t....................................................................................................................................................................................................	0	440	839	1305
+7862	PF08031	BBE		Berberine and berberine like 	Mistry J	anon	Pfam-B_649 (release 16.0)	Domain	This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids.  They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine [1][2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.32	0.72	-4.05	67	2389	2012-10-02 00:48:38	2004-12-20 08:43:13	7	38	719	49	1461	2372	41	47.30	32	9.22	CHANGED	uYlNahDhDls..........................asppYat.sN.apRLhplKspa..DPsNhF+ppQSIs	...................................sYlNah.-.h.s.s................................sa...tpt.aaG...sN....as....RLtplKp+a..DPpslF.p.....psl.............	0	342	871	1216
+7863	PF01238	PMI_typeI		Phosphomannose isomerase type I	Finn RD, Bateman A	anon	Prosite	Family	This is a family of Phosphomannose isomerase type I enzymes (EC 5.3.1.8).	20.20	20.20	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.26	0.70	-5.49	8	4066	2012-10-10 13:59:34	2004-12-31 11:15:28	16	20	2915	8	847	2789	266	273.80	26	82.30	CHANGED	LF+LpsuhppYsWG.hGspSAlAchhuho...sPS...lttsKPYAELWMG.THPpuPS+..lhssp.....l+slshsphhAhhsEslu....c+a..uu..pLPFLFKVLSlccsLSIQsHPsKc.uch..........LHstsP+NYPD-NHKPEhuIAlTsFcuhCGF+.htplsp.LtpssElpplIsscsusphppshph.s..ts.-shp.ph.lLpslFuplhsoss-clpppsshLlcptpsps....ushpthD........hsplIpRLpp.aPsDlGlFs..hhLNhhcLpsGEAhFLc..........AssPHAYlpGDhlECMAsSDNsVRAGhTPKahDVssLspMLsYpapss...-ctcht....pc...shhpu........SlLasP.Plt-Fulhps...slc..sGcphl.sh.susSILlsstGsuplhsusp	.........................................................................Lps..hp.phhW.......G..............stltp..h.h...u..hp.........Ps................ps...hu.EhW.....hh..AH.Pp.u.s......St.......l.h...sut........................hps.h.....h...h...s..p..h.....h.....s...........h.....t..c.h.h.s.........................p.p.h......sp........hPh...LhK.........lLsAppsLSlQVHPs.......................................................c.......s......Yt........t....H....c.s..Ehs.....................ps.s...ha..................h........p..ht...h.s.p.l.l.............s......h.....t.s..t....p...h....t...........t.h..........h.......t...h...........p.............pt.h........htt............F.....hl....s.s.......s.......c.......t.....t....t.h..hh.l....h....p....t........p...s...p.s............sp..h...h...............................h....h............t.....s.u..h............h.....................s..........sh...........................................h....s....hh.t.....................................................................................................................................................................................................t...................................................................................................................................................................................................................	0	291	516	721
+7864	PF08032	SpoU_sub_bind		RNA 2'-O ribose methyltransferase substrate binding	Finn RD	anon	Pfam-B_742 (release 16.0)	Domain	This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.37	0.72	-3.81	127	7167	2012-10-10 14:40:03	2005-01-04 15:00:01	7	11	4492	7	1567	4691	2075	74.30	22	27.20	CHANGED	hlhGh+sVhcALps...t..p...lpcl..alpps.....t.p.........plhphsppp..sltlthlscpt.Lsplst.sssHQGllAhlp.hphh	..............................................hlhGh+sVppuLps............s..p......lpcl..altcs.......tstp..............h..ppll.phhppp.......tl...t......l.p...h..l....sc..p.t....Ls..p.....h...u.........s...s.......s...s.....HQ.....Glhuhlp.h...t....................	0	500	998	1314
+7865	PF08033	Sec23_BS		Sec23/Sec24 beta-sandwich domain	Finn RD	anon	Manual	Domain	\N	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.06	0.72	-3.47	141	1441	2009-01-15 18:05:59	2005-01-05 11:01:17	7	32	326	24	954	1393	15	91.90	29	10.61	CHANGED	uapushcl+sSpsl+lsshhGshhst........s........................sss..hphsslssspohslhh....ch................................stp..lstt.ptsalQhshhYpss.sG.p+RlRVpTlshshs	.........................uFpAshclRsS.p.s......l..+lsshh.Gshhst..............s...........................................sss....hph..ssls.scpshu.l.hch................................sss....lsps..stshh....QhshhYoss..sG.p.RRlRVpTlshsh............................	0	314	512	772
+7866	PF08034	TES		Trematode eggshell synthesis protein	Ebersberger I, Finn RD	anon	Ebersberger I	Domain	This domain has been identified in a number of distantly related species  of trematodes. This protein domain is crucial for eggshell synthesis in trematodes (Ebersberger I).	21.20	21.20	21.40	22.20	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.18	0.72	-3.90	13	56	2009-01-15 18:05:59	2005-01-05 16:40:20	6	1	7	0	17	90	0	66.20	37	27.38	CHANGED	hpucGcFtupGspccGspappsTpF++GGGhDpYG+K+pa.scY-ThGphK+Yusphhps+FDlhGpL	............pu+G+hpupGptchGsp.ppsTpFphtGthspYG++.K.pa.ucacTpG+.KKYuc+hhcs+FDlhGsL..........	0	17	17	17
+7867	PF08035	Op_neuropeptide		Opioids neuropeptide	Bateman A, Lee SC	anon	Prosite	Family	This family corresponds to the conserved YGG motif that is found in a wide variety of opioid neuropeptides such as enkephalin.	20.40	20.40	20.40	22.50	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.24	0.72	-4.37	14	584	2009-01-15 18:05:59	2005-01-07 15:32:49	6	5	291	0	25	585	0	23.60	87	11.63	CHANGED	YGGFM+s..ERuQ.pPLlTLFKNlhhKss.cp	..YGGFMTP..ERSQ.TPLhTLFKNsIlK.........	0	1	4	9
+7868	PF08036	Antimicrobial_6		Diapausin family of antimicrobial peptide	Lee SC	anon	Short protein clustering	Family	This family consists of diapausin-related antimicrobial peptides. Diapause during periods of environmental adversity is an essential part of the life cycle of many organisms with the molecular basis being different among animals.  Diapause-specific peptides provide anti-fungal activity and act as N-type voltage-gated calcium channel blocker [1].	25.00	25.00	27.90	29.50	20.00	17.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.27	0.72	-4.20	3	10	2009-01-15 18:05:59	2005-01-07 16:23:30	6	1	6	1	5	5	0	39.60	52	63.36	CHANGED	VRVGPCDQVCSRIsPEKDECCRAHG+uGHAoCShGGMpC	..VRVtsCDpVCuRIssERDECCRAHGY.pGh..u...CpsGph.C.............	0	5	5	5
+7869	PF08037	Attractin		Attractin family	Lee SC	anon	Short protein clustering	Family	This family consists of the attractin family of water-borne pheromone. Mate attraction in Aplysia  involves a long-distance water-borne signal in  the form of the attractin peptide, that is released  during egg laying. These peptides contain 6 conserved  cysteines and are folded into 2 antiparallel helices.  The second helix contains the IEECKTS sequence conserved in Aplysia attractins [1].	25.00	25.00	28.80	93.30	18.40	17.80	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.11	0.72	-4.19	2	5	2009-01-15 18:05:59	2005-01-07 16:32:56	6	1	5	1	0	6	0	54.20	59	89.14	CHANGED	CDIt.hTSpCpMpapsCt-AsuCsslIEECKTSh.EcC..pphpSstuSTTltPp	CDIGNITSQCcMQHQNCuDAsGCsTlIEECKTSMVERCQNQpF-SuSuSTTLGPQ	0	0	0	0
+7870	PF08038	Tom7		TOM7 family	Lee SC	anon	Short protein clustering	Family	This family consists of TOM7 family of mitochondrial import receptors. TOM7 forms part of the translocase of the outer mitochondrial membrane (TOM) complex and it appears to function as a modulator of the dynamics of the mitochondrial protein transport machinery by promoting the dissociation of subunits of the outer membrane translocase [1].	21.20	21.20	23.10	23.40	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.98	0.72	-4.50	24	216	2009-01-15 18:05:59	2005-01-07 16:46:53	7	6	183	0	140	201	0	41.70	39	54.60	CHANGED	KERlshlhchu+sssHYGaIPLllYLGhspsss...P.......olhpLL	..........K-Rlsplhchu+sshHaGFIPhVlYLGappssss....P.......olhpLL..................	0	39	70	116
+7871	PF08039	Mit_proteolip	Mit_preoteolip; 	Mitochondrial proteolipid	Lee SC	anon	Short protein clustering	Family	This family consists of proteins with similarity to the mitochondrial proteolipids. Mitochondrial proteolipid consists of about 60 amino acids residues and is about 6.8 kDa in size [1].	25.00	25.00	25.90	25.80	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.94	0.72	-3.99	2	43	2009-01-15 18:05:59	2005-01-07 16:49:16	6	1	26	0	17	44	0	55.50	65	94.05	CHANGED	MLQSlIKplWIPMKPYYTpsYQEIWlGhGLMuaIVYKIRuADKRSKALKASusAP..GHH	.......MLQSlIKNVWlPMKPYYTQVYQEIWVGMGLMuaIVYKIRSADKRSKALKu.u.sAP..GH..........	0	2	2	4
+7872	PF08040	NADH_oxidored		MNLL subunit	Lee SC	anon	Short protein clustering	Family	This family consists of the MNLL subunits of NADH-ubiquinone  oxidoreductase complex. NADH-ubiquinone oxidoreductase is involved in the transfer of electrons from NADH to the electron  transport chain. This oxidation of NADH is coupled to proton  transfer across the membrane, generating a proton motive force  that is utilised for the synthesis of ATP [1]. MNLL subunit is   one of the many subunits found in the complex and it contains  a mitochondrial import sequence. However, the role of MNLL  subunit is unclear [2].	20.00	20.00	20.30	33.40	19.90	16.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.81	0.72	-4.35	5	67	2009-01-15 18:05:59	2005-01-07 16:50:39	6	1	53	0	33	69	0	56.50	50	88.18	CHANGED	MVNLhthsR-HWValLVPL.GFVlGpYLDRppDERLTAFRNKSALYutRELKPGE-sTWK	..................hshhthhp-+WlallVPh...GF...llGpYLD++pDE+LTsFRNKShLat.R..-LpPsEcsoW.....	0	7	10	21
+7873	PF08041	PetM		PetM family of cytochrome b6f complex subunit 7	Lee SC	anon	Short protein clustering	Family	This family consists of the PetM family of cytochrome b6f complex subunit IV. The cytochrome b6f complex consists of 7 subunits and contains 2 beta hemes and 1 chlorophyll alpha per cytochrome f. It is highly active in transferring electrons from decylplastoquinol to oxidised plastocyanin [1].	23.30	23.30	29.40	28.80	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.13	0.72	-4.46	21	131	2009-01-15 18:05:59	2005-01-07 16:53:32	6	2	113	9	56	116	5	31.40	46	45.33	CHANGED	uE..IhssAslshsLlLlGLuhGFhLLKl.Q...G..E	......uE...IFssAslhhsLlLVGLAlGFlLLKl.Q...u...t......	0	15	41	53
+7874	PF08042	PqqA		PqqA family	Lee SC	anon	Short protein clustering	Family	This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group  of many quinoproteins catalysing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are  unclear [1].	21.10	21.10	21.40	22.70	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-5.97	0.72	-6.22	0.72	-4.20	26	215	2009-01-15 18:05:59	2005-01-07 17:13:00	6	1	181	0	84	150	7	20.90	53	63.51	CHANGED	M...........tWspPphs-lplGhElshY	..................M...........tWo+Psas-lRlGhEVThY.	0	19	39	63
+7875	PF08043	Xin	Actin_bind_SAA; 	Xin repeat	Wu X, Finn RD	anon	Wu X	Repeat	The repeat has the consensus sequence GDV(K/Q/R)(T/S/G)X(R/K/T) WLFETXPLD.  This repeat motif is typically found in the N-terminus of the proteins, with a copy number between 2 and 28 repeats.  Direct evidence for binding to and stabilising F-actin has been found [1] in the human protein Swiss:Q702N9. The homologues in mouse and chicken localise in the adherens junction complex of the intercalated disc in cardiac muscle and in the myotendon junction of skeletal muscle. mXin may co-localise with Vinculin which is known to attach the actin to the cytoplasmic membrane [1]. It has been shown that the amino-terminus of human xin (CMYA1) binds the EVH1 domain of Mena/VASP/EVL, and the carboxy-terminus binds the, for the filamin family unique, domain 20 of filaminC [4]. This confirms the proposed role of xin repeat containing proteins as F-actin-binding adapter proteins.	20.00	20.00	23.60	20.00	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.10	0.74	-6.17	0.74	-3.83	60	1090	2009-01-15 18:05:59	2005-01-10 11:10:43	7	19	36	0	561	928	0	16.00	62	7.03	CHANGED	GDVpss+alFETpPLD	..GDV+os+WLFETQPLD.	0	22	78	230
+7876	PF08044	DUF1707		Domain of unknown function (DUF1707)	Lai X, Finn RD	anon	Lai X	Domain	This domain is found in a variety of Actinomycetales proteins.  All of  the proteins containing this domain are hypothetical and probably membrane bound or associated. Currently, it is unclear to the function  of this domain.	26.30	26.30	26.50	26.40	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.39	0.72	-4.21	59	938	2009-09-10 22:21:14	2005-01-10 16:55:33	6	10	341	0	294	719	4	52.70	37	25.50	CHANGED	hRsuDsDRppssphLspAhAcGpLshsEa-cRlstAhsAcThu-LssLhsDLP	....hRsuDs-RcpshphLpsAhucGcLshsEa--RlspAhtApThu-LsslhsDLP....	0	125	230	276
+7877	PF08045	CDC14		Cell division control protein 14, SIN component	Wood V, Mistry J	anon	manual	Family	Cdc14 is a component of the septation initiation network (SIN) and is required for the localisation and activity of Sid1.  Sid1 is a protein kinase that localises asymmetrically to one spindle pole body (SPB) in anaphase disappears prior to cell separation [1] [2].	20.40	20.40	20.40	21.00	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.72	0.70	-5.26	13	152	2009-01-15 18:05:59	2005-01-11 12:58:53	6	7	134	0	108	153	0	243.70	30	80.45	CHANGED	MEslLupuhDpLsopcsscIppGL+Ql-ulLuplshshsptppssh.............................tsssuhcE.FhpLQ-uFpaNlA..p+Llssl-hlhspss..pu......psshLlhs.lcLlQGlLLLHPsSRslFu.RctsMshlLcLL.............csssssslpsuslpTLlshLLcsPsNhRsFEclsGLtplsphFKhpps............................sp-l....+hKIlEFLhFYLhsEssshs.............................psttstt..t.t.......p+TspEKppLlt+hhsp.l-uLV--Lp-hpsh	.......................................................................................................................................h.hthp.L..p.....pl+pGL+pscuhLuplphpt.p..t....t......pt....s..........................p.lt..hp.ps.uh.p-.F.hLQc.sF..paNlt........cLls.s.......L...-..clhupt.s..ph.............psDhl..l...hssLcllQGshLLHPsS+sLFs.+chhhpl.LLcLL......................................ps.s.s..sslQuu.sL.oLlshLlDsPsNpR.sFEphsGL.pVssLhKp+ps............................sccl+hKllEFLhhYLhsE.s..s................................................................................p..hh..............................................................................	0	29	63	93
+7878	PF08046	IlvGEDA_leader		IlvGEDA operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leader peptides of ilvGEDA  operon. The expression of the ilvGEDA operon of E coli  K-12 is multivalently controlled by the three branched -chain amino acids. Regulation is thought to occur by  attenuation of transcription in response to the changing  levels of the cognate tRNAs. Transcription of this operon  is usually terminated at the end of the leader (regulatory)  region [1].	25.00	25.00	49.30	49.30	17.90	17.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.31	0.72	-7.59	0.72	-4.80	2	92	2009-09-11 14:17:33	2005-01-11 13:56:14	6	1	92	0	8	16	0	31.90	94	95.19	CHANGED	MphllQVIsLVlISVVVIIIPPCGAALGRhKA	.MTALLRVISLVVISVVVIIIPPCGAALGRGKA.	0	1	4	6
+7879	PF08047	His_leader		Histidine operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leader peptide of  the histidine (his) operon. The his operon contains  all the genes necessary for histidine biosynthesis.  The region corresponding to the untranslated 5' end  of the transcript, named the his leader region, displays  the typical features of the T box transcriptional  attenuation mechanism which is involved in the regulation  of many amino acid biosynthetic operons [1].	25.00	25.00	32.40	32.30	17.00	14.90	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.31	0.72	-6.69	0.72	-4.51	4	51	2009-01-15 18:05:59	2005-01-11 13:57:05	6	1	50	0	5	10	0	15.70	96	100.00	CHANGED	MsRVQFKpHHHHHHPD	MTRVQFKHHHHHHHPD	0	1	2	4
+7880	PF08048	RepA1_leader		Tap RepA1 leader peptide	Lee SC, Rossi R	anon	Short protein clustering	Family	This family consists of the RepA1 leader peptides.  The frequency of replication of IncFII plasmid NR1 during the cell division cycle is regulated by the control of the synthesis of the plasmid-specific replication initiation protein (RepA1). When RepA1 is synthesised, it binds to the plasmid replication origin (ori) and effects the assembly of a replication complex composed of host proteins that mediate the replication of the plasmid [1]. The tap gene encodes a 24-amino acids protein. The translation of tap is required for translation of repA.	25.00	25.00	31.00	38.80	16.60	15.50	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.84	0.72	-6.96	0.72	-3.89	5	34	2009-01-15 18:05:59	2005-01-11 13:58:01	7	1	28	0	2	20	0	24.40	70	100.00	CHANGED	MLRKlQYhFLCHLLLPCNISAGRCD	MhtKlQ.hFLppLLL.CIVSAGhCD.	0	0	0	2
+7881	PF08049	IlvB_leader		IlvB leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leader peptides of the ilvB operon. This region encodes a potential leader polypeptide containing 32 amino acids, 12 of which are the regulatory amino acids valine and leucine. A model for the multivalent regulation of this operon by valyl- and leucyl-tRNA is proposed on the basis of the mutually exclusive formation of five strong stem-and-loop structures in the leader mRNA [1].	25.00	25.00	33.50	31.20	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.66	0.72	-4.20	4	116	2009-01-15 18:05:59	2005-01-11 13:59:13	6	1	113	0	11	28	0	31.90	83	99.14	CHANGED	MNsShhNusLLsTA.sAAVVVVRVVVVVGNAP	............MssSMlNApLL.sTAPSAAVVVVRV...V..VVVGNAP	0	1	4	7
+7882	PF08050	Tet_res_leader		Tetracycline resistance leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tetracycline resistance leader peptide. The presence of 3 inverted repeats  which can form 2 different conformations of mRNA  suggests that the tetracycline resistance (TcR) region is regulated by a translational attenuation mechanism. A Rho-independent transcriptional terminator structure is present immediately after the translational stop codon  of the TET protein [1].	16.30	16.30	16.30	16.30	16.20	16.10	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.11	0.72	-6.36	0.72	-4.32	4	14	2009-01-15 18:05:59	2005-01-11 14:00:00	7	2	12	0	2	9	0	18.50	79	22.44	CHANGED	MKCpKMNRVQLKEGSVSMsL	MKCNECNRVQLKEGSVShsL.	2	1	1	2
+7883	PF08051	Ery_res_leader1		Erythromycin resistance leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of erythromycin resistance gene leader peptides.  These leader peptides are involved in the translational attenuation of erythromycin resistance genes. Interestingly, the consensus sequence of peptides conferring erythromycin resistance is similar to that of the leader peptides, thus indicating that a similar type of interaction between the nascent peptide and antibiotics can occur in both cases [1]. This family also includes a small number of regions from within larger proteins from actinomycetes.	22.80	22.80	23.10	23.10	22.60	21.00	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.79	0.73	-6.06	0.73	-4.12	10	16	2009-01-15 18:05:59	2005-01-11 14:00:36	6	2	13	0	8	11	0	15.00	72	8.77	CHANGED	MLISGTAFLRLRTNR	hhhSGsAaLRLRTsR	0	1	4	6
+7884	PF08052	PyrBI_leader		PyrBI operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the pyrBI operon leader peptides. The expression of the pyrBI operon, which encodes the subunits of the pyrimidine biosynthetic enzyme aspartate transcarbamylase.  is regulated primarily through a UTP-sensitive transcriptional attenuation control mechanism.  In this mechanism, the concentration of UTP determines the extent of coupling between transcription and translation within the pyrBI leader region, hence determining the level of rho-independent transcriptional termination at an attenuator preceding the pyrB gene [1].	25.00	25.00	34.20	34.20	17.90	15.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.20	0.72	-4.15	2	185	2009-01-15 18:05:59	2005-01-11 14:01:14	6	1	184	0	5	32	0	38.10	90	91.70	CHANGED	MVQCVRHFVLPRLKKDAGLPFFFPLITHSQPLNRGAFFC.GVRR	MVQCVRH.VLPRLKKDAGLPFFFPL.hT.popPLN..................	0	1	1	5
+7885	PF08053	Tna_leader		Tryptophanese operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tryptophanese (tna) operon leader peptide. Tna catalyses the degradation of L-tryptophan to indole, pyruvate and ammonia, enabling the bacteria to utilise tryptophan as a source of carbon, nitrogen and energy.  The tna operon of E. coli contains two major structural genes, tnaA and tnaB. Preceding tnaA in the tna operon is a 319 -nucleotide transcribed regulatory region that contains the coding region for a 24-residue leader peptide, TnaC. The RNA sequence in the vicinity of the tnaC stop codon is rich in Cytidylate residues which is required for efficient Rho -dependent termination in the leader region of the tna operon [1].	25.00	25.00	70.80	70.70	17.20	16.70	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.78	0.72	-6.97	0.72	-4.56	2	48	2009-01-15 18:05:59	2005-01-11 14:01:50	6	1	46	0	2	6	0	24.00	99	98.63	CHANGED	MNILHlCVTSKWFNIDNKIVDHRP	MNILHICVTSKWFNIDNKIVDHRP	0	1	1	1
+7886	PF08054	Leu_leader		Leucine operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the leucine operon leader peptide. The leucine operon is involved in the control of the biosynthesis of leucine. Four adjacent leucine codons within the leucine leader RNA are critically important in transcription attenuation-mediated control of leucine operon expression in bacteria. The leader RNA contains translational start and stop signals, a cluster of four leucine codons and overlapping regions of dyad symmetry that are capable of forming stem-and-loop structures [1].	25.00	25.00	26.30	26.30	22.60	19.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.92	0.72	-7.16	0.72	-4.27	4	72	2009-01-15 18:05:59	2005-01-11 14:02:44	6	1	72	0	7	20	0	27.80	79	95.61	CHANGED	MhHhsRhhu.LLLNA.llRGh.VuG.Qp	.....MoHIVRFlGLLLLNASpLRGRhVuGIQH...	0	2	3	6
+7887	PF08055	Trp_leader1		Tryptophan leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tryptophan (trp) leader peptides. Tryptophan accumulation is the principal event resulting in downregulation of transcription of the structural genes of the trp operon. The leader peptide of the trp operon forms mutually exclusive secondary structures that would either result in the termination of transcription of the trp operon when tryptophan is in plentiful supply or vice versa [1].	25.00	25.00	48.60	48.50	16.40	14.90	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.54	0.72	-6.78	0.72	-4.36	2	2	2009-01-15 18:05:59	2005-01-11 14:03:54	6	1	2	0	0	2	0	18.00	78	100.00	CHANGED	MFA.phpNWWWTAHPAAH	MFA.phpNWWWTAHPAAH	0	0	0	0
+7888	PF08056	Trp_leader2		Tryptophan operon leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tryptophan operon  leader peptides. The tryptophan operon is regulated  by transcription attenuation in response to changes  in the level of tryptophan. The transcript of the  leader peptide can adopt alternative mutually-exclusive  secondary structures that would either result in  termination of transcription of the tryptophan structural  genes or in transcription of the entire operon [1].	21.00	21.00	27.00	59.20	20.00	19.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.34	0.72	-3.96	4	77	2009-01-15 18:05:59	2005-01-11 14:04:29	6	1	75	0	5	24	0	37.70	82	87.76	CHANGED	MLQEFNpNpKsKlu.h.p.ssuAELAWWRTWTSSWWANVYF	MLQEFNPNHKPNFS.........PADA....ELAWWRTWTSSWWAHVYF	0	1	1	3
+7889	PF08057	Ery_res_leader2		Erythromycin resistance leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of erythromycin resistance gene leader peptides.  These leader peptides are involved in the transcriptional attenuation control of the synthesis of the macrolide-lincosamide -streptogramin B resistance protein. It acts as a transcriptional attenuator, in contrast to other inducible erm genes. The mRNA leader sequence can fold in either of two mutually exclusive conformations, one of which is postulated to form in the absence of induction, and to contain two rho factor-independent terminators. [1].	25.00	25.00	42.70	42.70	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.07	0.73	-6.10	0.73	-3.49	2	2	2009-01-15 18:05:59	2005-01-11 14:05:10	6	1	2	0	0	1	0	14.00	100	100.00	CHANGED	MTHSMRLRFPTLNQ	MTHSMRLRFPTLNQ	0	0	0	0
+7890	PF08058	NPCC		Nuclear pore complex component	Wood V, Mistry J, Novatchkova M	anon	manual	Domain	Proteins containing this domain are components of the  nuclear pore complex [1].  One member of this family  is Nucleoporin POM34 (Swiss: Q12445) which is thought to have a role in  anchoring peripheral Nups into the pore and mediating pore formation [1].	26.80	26.80	58.40	28.40	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.75	0.71	-4.33	21	117	2009-01-15 18:05:59	2005-01-11 15:00:35	6	5	109	0	89	110	0	130.40	31	39.27	CHANGED	GsWcpPhlcElsRRQ...s.p-ppl++llhNshuhlhh.lhsphlp.hh.hhphspth.s..........................................asphhhhllphlhllNIllALasLh+s..pDshuDlPLTspQRcLLGLsss............spTsush.....hlTPP+Yph	..............................GsWcpPhLcEls+Rp...s.p..Eppl++lhhNshslhhh.hhtphhp.hh.hhththph..s..........................................asshlhhllpllhhlNIlhuLh....Lh+...pDchuDlPLTspQRpLLGLcss.st..................ssssssh.....h.p.P+Yp..............................	0	14	44	75
+7891	PF08059	SEP		SEP domain	Mistry J, Wood V	anon	Pfam-B_1894 (release 16.0)	Domain	The SEP domain is named after Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47.  In p47, the SEP domain has been shown to bind to and inhibit the cysteine protease cathepsin L [1].  Most SEP domains are succeeded closely by a UBX domain [1].	21.50	21.50	21.70	21.70	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.27	0.72	-3.67	44	608	2009-01-15 18:05:59	2005-01-11 17:43:31	8	13	300	3	378	595	4	72.10	36	19.95	CHANGED	lphWpsGFol-DG.LRpacDPtNtpFLpslpcGcsPh-Lhsht.t.ppVsVslpc+pcEcYhtPhh..phpsFsGpGp	.......lplWcsG.Fol.s.D.Gs....LRsas...DP..s....N.tpFLc.......s.....I.p..cG........chPhELtp.h.....h.t....ppVslclpc+psEsahps.......thpsFsGpGp...................	0	118	184	273
+7892	PF08060	NOSIC		NOSIC (NUC001) domain	Staub E, Bateman A	anon	Staub E	Domain	This is the central domain in Nop56/SIK1-like proteins [1].	23.70	23.70	24.10	23.70	22.80	23.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.55	0.72	-4.16	101	1203	2009-09-11 13:22:58	2005-01-12 13:32:34	8	20	441	26	811	1191	39	52.30	44	10.32	CHANGED	hIlQulsll-clD+-lNhhthRlREWYuh+FPELspllsc.shpYu.+lVthlGs	........hIlQAluLLDpLDK-lNsasMRlREWYuaHFPELs+lls....D....shpYs.+llphlGp..............	0	287	457	669
+7893	PF08061	P68HR		P68HR (NUC004) repeat	Staub E, Bateman A	anon	Staub E	Repeat	This short region is found in two copies in p68-like RNA helicases [1].	25.00	25.00	30.50	33.30	23.60	24.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.31	0.72	-4.22	8	120	2009-01-15 18:05:59	2005-01-12 13:38:59	6	6	32	0	40	103	0	33.60	59	11.58	CHANGED	SAGhpuGFpohpsptsYppGYuu..pppaGupspN	..SAGhpsuFpT.hpsptsYppGYsS..pppaGupstN.	0	2	2	12
+7894	PF08062	P120R		P120R (NUC006) repeat	Staub E, Bateman A	anon	Staub E	Repeat	This characteristic repeat of proliferating cell nuclear antigen P120 is found in three copies [1].	20.30	20.30	21.70	20.30	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.62	0.73	-6.89	0.73	-3.37	6	44	2009-01-15 18:05:59	2005-01-12 13:43:13	6	5	10	0	8	55	0	21.90	49	6.15	CHANGED	sGKA+GspKsK.QQLh+Q.tsKt	.hGKAKGlcKsK.pph.KQ.tsKh.....	0	3	3	3
+7895	PF08063	PADR1		PADR1 (NUC008) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found in poly(ADP-ribose)-synthetases [1]. The function of this domain is unknown.	21.10	21.10	21.10	23.00	21.00	19.10	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.12	0.72	-4.57	17	187	2009-01-15 18:05:59	2005-01-12 14:18:02	7	27	111	4	131	208	2	54.70	41	6.18	CHANGED	ll-RluDshhFGsLt.CspCsG.phhapup..tYhCpG.l..StWoKC..sapspsPpRhp	.........ll-RlADshhFGALhsCsp..Csu.....pl..hapus..sYhCoGpl...otWoK.C..shpTpsPsRp...........	0	54	72	108
+7896	PF08064	UME		UME (NUC010) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is characteristic of UVSB PI-3 kinase, MEI-41 and ESR1 [1].	21.00	21.00	21.00	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.06	0.72	-4.09	29	246	2009-01-15 18:05:59	2005-01-12 14:25:06	8	14	218	0	176	262	1	105.80	24	4.49	CHANGED	lspaLppchLGllshFspslpc...sppshh-KccslpuIt.ll+.hstpplssshsQ......IhssLpouLchp...-LpptuhpsWplhlppLsp...pcltsllsphlshllphasp	...............hspaLpp+lLGllshFsppltc.....s.p.....tsh.-K+pslpultpll+.h.............ss.........pplssshsp.................lhssLpou.Lphc..........-lpph...s..hpsWsshlpsLsp...pcLtsllspslshll.hhp.h..............................	0	51	92	143
+7897	PF08065	K167R		K167R (NUC007) repeat	Staub E, Bateman A	anon	Staub E	Repeat	This family represents the K167/Chmadrin repeat [1]. The function of this repeat is unknown.	20.70	20.70	21.10	20.70	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.28	0.71	-3.97	24	437	2009-01-15 18:05:59	2005-01-12 14:29:07	7	18	30	0	146	511	0	104.90	42	46.71	CHANGED	sTKlsscSPQP-sscTssSoKppsKpuLpKs-V+EEh.AlpKhopouGcshcT.+.ssu-s+sIcuhhposKQKLDssusloGSKRp.pTPKE+AQsLEDLsG.FpELFQTPu	.......................TKhsC+Ss.s-slsTPsSp+p.......p.+pslt..Ks-lcEE.h.Al.p..KhTposGcsscT..+.....Ps.u-c+slcsa.....pcoP+QKL.Dsstsl.oGSKR...psRTP.K-K.A.Q.......sLEDLsG.FKELFQTP........	1	16	18	28
+7898	PF08066	PMC2NT		PMC2NT (NUC016) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found at the N-terminus of 3'-5' exonucleases with HRDC domains, and also in putative exosome components [1].	22.20	22.20	22.50	22.50	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.82	0.72	-3.69	31	282	2009-01-15 18:05:59	2005-01-12 14:35:30	7	8	228	0	176	278	0	91.50	28	11.48	CHANGED	llsss+uuuuLuu..pDlsFY+ohpsshuppl-ppupcLLslhspllp.thsspschhtss.......t.csl-s..pacsls-shDsLhE+sDpsLDchsGh	.............llsss+uu.suLsp....c-...hsFa+Sh.Psap...p.h-ppusRLLphhsp.lhp.htssp..s.shpsts...........................p.spl--..pa.c.h.ll-s.DslLE+sshhLDEhsG.l................	0	54	90	143
+7899	PF08067	ROKNT		ROKNT (NUC014) domain	Staub E, Bateman A	anon	Staub E	Domain	This presumed domain is found at the N-terminus of RNP K-like proteins that also contains KH domains Pfam:PF00013 [1].	19.90	19.90	23.40	22.80	18.60	18.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.13	0.72	-4.10	4	131	2009-01-15 18:05:59	2005-01-12 14:39:44	6	8	36	0	42	81	0	42.40	79	10.24	CHANGED	M-TE.-.Q.EEsoFSNsEoNGKRPAEDh-EEpuFKRSRNoDEMV	...........METE...Q.sEETFsNTETN...Gc..hGK...RPAEDME.EEQAFKRSRNTDEMV..	0	1	6	15
+7900	PF08068	DKCLD		DKCLD (NUC011) domain	Staub E, Bateman A	anon	Staub E	Domain	This is a TruB_N/PUA domain associated N-terminal domain of Dyskerin-like proteins [1].	20.90	20.90	20.90	20.90	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.76	0.72	-4.04	16	540	2009-01-15 18:05:59	2005-01-12 14:44:23	7	12	459	21	349	531	82	54.30	55	12.61	CHANGED	csupaPLLLKshc.+LhVRos.caTPhshGssPhcRsIcEYlchGlINLDKPusPSSHEVV	................sSpWPLLLKNa-.c.............L.VRos.HaTPl.stGssPL+RslppYlp.pGlINLDKPuNPSSHEVV........	0	117	200	290
+7901	PF08069	Ribosomal_S13_N		Ribosomal S13/S15 N-terminal domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found at the N-terminus of ribosomal S13 and S15 proteins.\	     This domain is also identified as NUC021 [1].	25.00	25.00	27.60	26.50	22.80	21.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.85	0.72	-4.13	64	646	2009-01-15 18:05:59	2005-01-12 14:52:27	7	7	524	8	365	560	71	58.50	55	38.20	CHANGED	MuRMHu+t..+..GhSuSshPh....+ppsPpWlp..hos-ElcchIlcLAK.+GhsPSpIGllLRDpaGI	.........................MGRMHutG..K..GlSpSAlPY....+RssP....sWlK..hos--Vc-pIhKLAK.KGhTPSQIGVlLRDuHGl...	0	115	203	297
+7902	PF08070	DTHCT		DTHCT (NUC029) region	Staub E, Bateman A	anon	Staub E	Family	The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins [1]. This region is composed of quite low complexity sequence.	19.70	19.70	20.50	20.40	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.39	0.72	-3.34	8	130	2009-09-10 16:42:44	2005-01-12 14:58:57	6	9	47	0	61	99	0	96.90	43	6.92	CHANGED	+AAPKusKp.......DS-hsuulsKKPsPsKuKs...p+KRKsSSSD-SDSsFtKtsSKusTSKKuK.......u-sDDFpsDhs....sss...APRs+SGRAKKPlKYLE	........................+tAPK.tpKh..........D.S-t.phu.l.sKKss.s..s...K.uKs......................++++tsuSps.-..uD.s.......t....+tsSK.....sssSKKsKp.............u-sDpF..s.Dhs.....ops.......ss+s+oGR..A.+K.lKYht............	1	6	9	25
+7903	PF08071	RS4NT		RS4NT (NUC023) domain	Staub E, Bateman A	anon	Staub E	Domain	This is the N-terminal domain of Ribosomal S4 / S4e proteins. This domain is associated with S4 and KOW domains [1].	20.40	20.40	20.60	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-7.69	0.72	-4.10	34	754	2009-01-15 18:05:59	2005-01-12 15:00:55	7	10	531	4	419	697	74	36.40	62	14.46	CHANGED	pGs+KHLKRlsAPppWhls+ps.utaAs+PSsGPHphcc	.....RGsKKHLKRLsAP++.WMLDKLs.GsaAPRPSsGPHKLRE.....	0	139	234	326
+7904	PF08072	BDHCT		BDHCT (NUC031) domain	Staub E, Bateman A	anon	Staub E	Domain	This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily [1].	25.00	25.00	41.50	40.30	18.10	16.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.06	0.72	-3.85	3	59	2009-01-15 18:05:59	2005-01-12 15:04:31	6	7	34	0	22	45	0	40.30	67	3.39	CHANGED	QLlSVME-ICKLVDsIPlcEL+lLSCGpELLQQRplRRKLL	.QLl+VMEcICKLVDTIPtDcLKsLcCGsELLQQRslRRKLL....	0	1	3	7
+7905	PF08073	CHDNT		CHDNT (NUC034) domain	Staub E, Bateman A	anon	Staub E	Domain	The CHDNT domain is found in PHD/RING finger and chromo domain-associated helicases [1].	20.80	20.80	21.00	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.54	0.72	-4.28	5	268	2012-10-02 14:16:02	2005-01-13 16:21:08	7	31	81	0	123	210	1	54.50	69	3.24	CHANGED	V-l-YoEEDacoLTNYKAFSpaVRPlIsKcNPKIssoKMMMLluAKWREFsssNP	...........l-alFSEEDY+TLTNYKAFSQFl..RPLIA.+KNPKIshSKMMhl......LGAKWREFSsNNP..........	0	20	32	70
+7906	PF08074	CHDCT2		CHDCT2 (NUC038) domain	Staub E, Bateman A	anon	Staub E	Domain	The CHDCT2 C-terminal domain is found in PHD/RING finger and chromo domain-associated CHD-like helicases [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.08	0.71	-4.53	4	307	2009-01-15 18:05:59	2005-01-13 16:28:26	6	33	89	0	132	242	0	160.40	78	10.29	CHANGED	KhsEIWHRRHDaWLLAGlslHGYARWQ....DItNDspFAIlNEPFKspusc..sNFLEhKNKFLARRFKLLEQALVIEEQLRRAAaLNhpQ-PsHPAMALsARFAElECLAESHQHLSKEShsGN+sANAlLHKVLsQL--LLuDhKsDVsRLPuTlSpltP..VssRLtMSERpILSpL	........................Kh.EIWHRRHDYWLLAGIlp........HGYAR....WQ.................DIQNDsRaAIlNEPF.........KsEhsK.........GNFLEhKNKFLARRF.K..L..LEQALVIEEQLRRAAYLN.hop.DPuH...P...uMALNsRFAEV...ECLAESHQHLSK.EShA.GNKPANAVL.HK....VLsQLEELLSDMKADVTRLPATLuRIPP..VAsRLQMSERsILSRL...................	0	26	37	75
+7907	PF08075	NOPS		NOPS (NUC059) domain	Staub E, Bateman A	anon	Staub E	Domain	This domain is found at the C-terminus of NONA and PSP1 proteins  adjacent to 1 or 2 Pfam:PF00076 domains [1].	20.20	20.20	20.30	24.50	19.90	18.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.50	0.72	-3.56	11	282	2009-01-15 18:05:59	2005-01-13 16:34:28	6	8	89	2	146	244	1	51.10	64	10.43	CHANGED	PllVEPhEp.DDpDGLPEK.LspKsspapKEREpsPRFAp.GoFEaEYusRWK	.....PVlVEPhEQhDDE.DGLPEK.LspKs.pap...KEREpPPRFAQPGoFEaEYupRWK....	0	27	36	78
+7908	PF08076	TetM_leader		Tetracycline resistance determinant leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the tetracycline resistance  determinant tet(M) leader peptides. A short open  reading frame corresponding to a 28 amino acid peptide  which contain a number of inverted repeat sequences was  found immediately upstream of the tet(M). Transcriptional  analyses has found that expression of tet(M) resulted from an  extension of a small transcript representing the upstream  leader region into the resistance determinant. Thus this  leader sequence is responsible for transcriptional attenuation  and thus regulation of the transcription of tet(M) [1].	25.00	25.00	60.40	60.10	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.26	0.72	-4.39	3	31	2009-01-15 18:05:59	2005-01-14 11:01:15	6	2	28	0	1	8	0	27.70	92	72.55	CHANGED	MLChPMlMH+FPSDKSIYHWDFhuLFGF	MLChPMVMHKNPSDKSIYHWDFYALLGF	0	1	1	1
+7909	PF08077	Cm_res_leader		Chloramphenicol resistance gene leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of chloramphenicol (Cm) resistance  gene leader peptides. Inducible resistance to Cm in both  Gram positive and Gram negative bacteria is controlled  by translation attenuation. In translation attenuation,  the ribosome-binding-site (RBS) for the resistance  determinant is sequestered in a secondary structure domain  within the mRNA. Preceding the secondary structure is a  short, translated ORF termed the leader. Ribosome stalling  in the leader causes the destabilization of the downstream  secondary structure, allowing initiation of translation  of the Cm resistance gene [1].	25.00	25.00	48.90	48.80	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.15	0.73	-6.44	0.73	-3.94	2	3	2009-01-15 18:05:59	2005-01-14 11:02:43	6	1	3	0	1	1	0	17.00	100	100.00	CHANGED	MSGVPGALAVVTRRTIS	MSGVPGALAVVTRRTIS	0	0	0	1
+7910	PF08078	PsaX		PsaX family	Lee SC	anon	Short protein clustering	Family	This family consists of the PsaX family of photosystem I (PSI) protein subunits.\	      PSI is a large multi-subunit pigment protein complex embedded in the thylakoid membranes of green plants and cyanobacteria. PsaX is one of the 12 protein subunits found in PSI and these subunits are arranged as monomers or trimers within the membrane as shown by the structure of the trimeric complex from Synechococcus elongatus [1].	25.00	25.00	33.50	33.00	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.72	0.72	-4.03	2	15	2009-01-15 18:05:59	2005-01-14 11:04:10	7	1	15	2	6	15	0	36.10	63	68.65	CHANGED	SshAspuAKPsYsFRThWAlLLLAlNFLVAAYYFtIl	.........ssKuAKPsYsFRTuWAl.LLLAINFLVAAYYFHII	0	0	5	6
+7911	PF08079	Ribosomal_L30_N		Ribosomal L30 N-terminal domain	Staub E, Bateman A	anon	Staub E	Domain	This presumed domain is found at the N-terminus of Ribosomal L30 proteins and has been termed RL30NT or NUC018 [1].	23.90	23.90	24.20	24.90	23.80	23.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.49	0.72	-3.96	70	661	2009-01-15 18:05:59	2005-01-14 14:47:42	7	8	345	8	354	608	5	68.80	34	28.50	CHANGED	olLKKRKpppph+tpptppthtp+ttppp+RphIa+RAEpYhKEY+ptER-.IRLpRpA+ppGsaYVPuEs	................................olLKKRKp.pp.h+tpptppth.t.pKt......tp+tc..Rc.lIacRA.cpYhKEY+..........ptcRcpIRlpR.A+ptGsaYVPuEs...........	0	109	177	256
+7912	PF08080	zf-RNPHF		RNPHF zinc finger	Staub E, Bateman A	anon	Staub E	Domain	This domain is a putative zinc-binding domain (CHHC motif) in RNP H and F.  The domain is often associated with Pfam:PF00076.	20.20	20.20	20.80	21.10	18.00	19.20	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.96	0.72	-4.45	3	163	2009-01-15 18:05:59	2005-01-14 14:50:25	7	9	41	2	72	105	0	33.70	76	8.58	CHANGED	FGSDRFGRDLoYChSGMSDHRYGDGsSTFQSTTGHC	..........FsoD.hFGR.D..LsYChSG...MSD.HRYGDGGSTFQSTTGHC.......	0	4	8	18
+7913	PF08081	RBM1CTR		RBM1CTR (NUC064) family	Staub E, Bateman A	anon	Staub E	Family	This C-terminal region is found in RBM1-like RNA binding hnRNPs [1].	22.00	22.00	22.60	25.80	21.60	18.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.27	0.72	-4.23	8	128	2009-01-15 18:05:59	2005-01-14 14:57:06	6	3	49	0	49	133	0	45.30	69	12.12	CHANGED	SuusMG..GRushSRGRDuYG.GPPRR-shsSRRDsYhuPRDDGYSo+	...............SSSGMG..GRAPlSRGRDuYG.GPP.RREPlPSRRDVYLSPRDDGYSTK......	0	9	11	19
+7914	PF08082	PRO8NT		PRO8NT (NUC069), PrP8 N-terminal domain	Staub E, Bateman A	anon	Staub E	Domain	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].	25.00	25.00	25.00	31.00	21.00	24.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.99	0.71	-4.57	24	428	2009-01-15 18:05:59	2005-01-14 14:59:30	6	30	362	0	242	401	7	136.00	71	7.54	CHANGED	Kt-MPPEHLRKIl+DHGDMSS++apsDKRsaLGALKYlPHAlhKLLENMPhPWEps+pVKVLYHhoGAITFVNElP+VIEPlYhAQWuTMWlhMRREK....RDR+HFKRMRFPPFDDEEPPLDYu-Nl.DlEP.-uIphcLDpp-DssVhDWhYD	.....................................Kt-MPPEHlRKIl+................DhGDhop+KappDKRsYLG...ALKahPHAlhKLLENMPMPWE.plR-VcVLYHITGAITFVNEIPhVIEPVYlAQWGoMWIMMRREK....RDRRHFKRMRFPPFDDEEPPLDYuD.NlLDVEPLEsIQh.ELDp-EDss.Vh-WFYD................................	0	94	143	205
+7915	PF08083	PROCN		PROCN (NUC071) domain	Staub E, Bateman A	anon	Staub E	Domain	The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family [1].	19.80	19.80	19.80	19.90	19.70	18.90	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.45	0.70	-6.00	12	433	2009-01-15 18:05:59	2005-01-14 15:01:09	6	40	348	0	269	361	13	328.20	62	18.09	CHANGED	LhscpTpsuh...tLhaAPhPFN++pGt......h+RAtDlsLlKpWapp+ss...sshPsKV+VSYQKLLKsaVhNpL+p.......pc.psppK............hpLL+sLKsTKFFQpTpIDWVEAGLQlCRQGaNMLNLLIHRKsLsYLHLDYNFNLKPsKTLTTKERKKSRFGNAFHLhREIL+hhKllVDuHVQaRLGNlDAaQLADGltYIhsHlGQLTGlYRYKYKlM+QIRtCKDLKHll.YhRFNs..lGKGPGCGFWtPuWRVWlFFLRGIIPLLERWLGNLLsRQFEGRpSpsl..sKTlTKQRl-SaaDLELRAuVMpDILDMlP-Gl+..psKuRTILQHLSEAWRCWKANlPWcVPGhPtPlcsIIhRYlKuKADhWhssAaYNR-RI+RGAsV-KTlsKKNLGRLTRLWlKsEQERQ+phhK..-GPhl	.....................................................sppTssuI...sLhaAPhPFshRSG+......hhRA.D.....lPLlppWY..h.EHsP....s.PVKVRVSYQKLLKhaVLNtL+p.......+..PK...s.p.pK....................p.Lh+shKsT.KFFQpTplDWVEsGLQVCRQGaNMLNL.LIHRKsLsYLHLDYNFNLKPlKTLTTKERKKSRFGNAFHLhRE.lLRLoKLlVDupVQaRLGNlDAaQLADGl.YhFs...HVGQLTGMYRYKY+LM+QIRhCKDLKHlI.YYRFNoGsVGKGPGCGFWAPuWRVWlFFhRGIhPLLERWLGNLLuRQF..E..GRcSKGl..AKTVTKQRVESHaDLELRAuVM+DllDMMP.E.GlK..................QNKsRTILQHLSEAWRCW.........KANIPWK...............VP..GLPhPIENhILRYVKtKADWWhssAHYNRERI+RGATVDKTVsKKNLGRLTRLaLKuEQERQ+sYhK..DGPYl.............................	0	108	159	227
+7916	PF08084	PROCT		PROCT (NUC072) domain	Staub E, Bateman A	anon	Staub E	Domain	The PROCT domain is the C-terminal domain in pre-mRNA splicing factors of PRO8 family [1].	19.50	19.50	19.70	20.00	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.76	0.71	-4.42	32	394	2009-01-15 18:05:59	2005-01-14 15:02:50	6	37	344	4	235	386	4	107.70	55	5.71	CHANGED	slslolSFoPGSsolsAapLTppGapWGt...pNpDhhsppPpGapssahc+sQlLLSD+hhGaFhVPcsslWNYsFhGspas...shpYslpl-hPhsFYc-lHRPtHFlpFscl....tts-.phpsD.-ssF	.......................TlhlTsSFTPGSsSLoAY+LTPsGYEWG+...pNpD........t.u..sp..Pp......Ga..s.o..hhE+sQhLLSD+hhGaFhVPp.pss.WNYsF.M..Gspas....phpaplpls.sPhpFYc-.HRP.HFhpFupl.........-...h.sDppD.............................	2	85	132	194
+7917	PF08085	Entericidin		Entericidin EcnA/B family	Lee SC	anon	Short protein clustering	Family	This family consists of the entericidin antidote/toxin peptides. The entericidin locus is activated in stationary phase under high osmolarity conditions by rho-S and simultaneously repressed by the osmoregulatory EnvZ/OmpR signal transduction pathway. The entericidin locus encodes tandem paralogous genes (ecnAB) and directs the synthesis of two small cell-envelope lipoproteins which can maintain plasmids in bacterial population by means of post-segregational killing [1].	23.30	23.30	23.30	23.30	23.20	23.10	hmmbuild  --amino -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.26	0.73	-6.22	0.73	-4.02	64	1429	2012-10-01 23:27:00	2005-01-14 17:10:06	6	3	892	0	211	521	26	21.00	57	43.49	CHANGED	NTspGsGcDlpsuGpAlpcuA	.NTsRGhGEDIpcuGsAISpAA.....	0	33	99	154
+7918	PF08086	Toxin_17		Ergtoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of ergtoxin peptides which are toxins secreted by the scorpions.\	 The ergtoxins are capable of blocking the function of K+ channels. More than 100 ergtoxins have been found from scorpion venoms and they have been classified into three subfamilies according to their primary structures [1].	25.00	25.00	83.10	83.00	23.30	21.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.46	0.72	-3.89	4	27	2012-10-01 23:31:40	2005-01-14 17:11:46	6	1	6	2	0	27	0	41.00	79	93.81	CHANGED	DRDSCVDKS+CuKYGYYtQCp-CCKKAGHsGGTChYFKCKC	.DRDSCVDKS+CuKYGYYtQCp-CCKKAGcpuGTChaFKCKC	0	0	0	0
+7919	PF08087	Toxin_18		Conotoxin O-superfamily	Lee SC	anon	Short protein clustering	Domain	This family consists of members of the conotoxin  O-superfamily. The O-superfamily of conotoxins  consists of 3 groups of Conus peptides that belong  to the same structural group. These 3 groups differ  in their pharmacological properties: the w-conotoxins  which inhibit calcium channels, the delta-conotoxins  which slow down the inactivation rate of voltage -sensitive sodium channels and the muO-conotoxins block  the voltage sensitive sodium currents [1].	24.30	24.30	26.10	26.10	22.10	21.30	hmmbuild  --amino -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.62	0.72	-4.17	7	30	2012-10-01 22:06:18	2005-01-14 17:12:28	6	1	24	0	0	32	0	31.10	72	56.38	CHANGED	hACsETGtsChaS.ECCS..GACSssFsaCL.p	.hACTETGRNCpaS.ECCS..GACSAsFsaCL.R....	0	0	0	0
+7920	PF08088	Toxin_19		Conotoxin I-superfamily	Lee SC	anon	Short protein clustering	Family	This family consists of the I-superfamily of  conotoxins. This is a new class of peptides in  the venom of some Conus species. These toxins  are characterised by four disulfide bridges and  inhibit of modify ion channels of nerve cells.  The I-superfamily conotoxins is found in five or  six major clades of cone snails and could possible  be found in many more species [1].	23.20	23.20	23.70	23.40	22.30	23.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.93	0.72	-4.05	8	26	2009-01-15 18:05:59	2005-01-14 17:13:11	7	1	5	3	0	29	0	40.30	66	83.17	CHANGED	G.s.CtpDt+sCsYHADCCN..CChtGhCpPSTsWI..GCSTus	...G.s.CtKDt+tCsYHADCCN..CCLo..GICtPSTsWI..GCSTu...	0	0	0	0
+7921	PF08089	Toxin_20		Huwentoxin-II family	Lee SC	anon	Short protein clustering	Family	This family consists of the huwentoxin-II (HWTX-II)  family of toxins secreted by spiders. These toxins are found in venom that secreted from the bird spider  Selenocosmia huwena Wang. The HWTX-II adopts a novel  scaffold different from the ICK motif that is found in  other huwentoxins. HWTX-II consists of 37 amino acids  residues including six cysteines involved in three  disulfide bridges [1].	25.00	25.00	31.80	51.80	21.20	19.70	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.41	0.72	-4.06	3	92	2009-01-15 18:05:59	2005-01-14 17:13:28	6	1	10	2	0	90	0	38.40	81	47.52	CHANGED	lFECoFSCDIEKEG.KPCKPKG..........+KKCSGGWKCKlKLCLKl	.LFECSlSCEIEKEG.....NKsCK.............KKKC..KGGWKCKFNMCVKV.	0	0	0	0
+7922	PF08090	Enterotoxin_HS1	Enterotoxin_ST; 	Heat stable E.coli enterotoxin 1	Lee SC	anon	Short protein clustering	Family	Heat-stable toxin 1 of entero-aggregative E.coli (EAST1) is a small toxin. It is not, however, solely associated with entero-aggregative E.coli but also with many other diarrhoaeic E. coli families. Some studies have established the role of EAST1 in some human outbreaks of diarrhoea. Isolates from farm animals have been shown to carry the astA gene coding for EAST1. However, the relation between the presence of EAST1 and disease is not conclusive [1].	25.00	25.00	73.10	73.10	19.70	17.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.93	0.72	-4.20	2	9	2009-01-15 18:05:59	2005-01-14 17:14:06	6	1	4	0	0	8	0	35.30	91	96.07	CHANGED	ShphIR+PASShASCIWCsTACuSs.GRTTKPS.AT	STQYIRRPASSYASCIWCATACASCHGRTTKPSLAT	0	0	0	0
+7923	PF08091	Toxin_21		Spider insecticidal peptide	Lee SC	anon	Short protein clustering	Domain	This family consists of insecticidal peptides isolated  from venom of spiders of Aptostichus schlingeri and  Calisoga sp. Nine insecticidal peptides were isolated  from the venom of the Aptostichus schlingeri spider and  seven of these toxins cause flaccid paralysis to insect  larvae within 10 min of injection. However, all nine  peptides were lethal within 24 hours [1].	20.10	20.10	20.20	22.50	19.80	19.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.54	0.72	-4.25	2	5	2012-10-01 22:06:18	2005-01-14 17:14:47	6	1	3	0	0	5	0	38.20	57	69.96	CHANGED	C.StthPCoNuc-CCuGpCuh.hWsCh..tssCSKpC.u.	CISARYPCSNSKDCCSGNCGs.FWTCalRKDPCSKECLAP.	2	0	0	0
+7924	PF08092	Toxin_22		Magi peptide toxin family 	Lee SC	anon	Short protein clustering	Family	This family consists of Magi peptide toxins (Magi 1, 2 and 5) isolated from the venom of Hexathelidae spider. These insecticidal peptide toxins bind to sodium channels and induce flaccid paralysis when injected into lepidopteran larvae. However, these peptides are not toxic to mice when injected intracranially at 20 pmol/g [1].	25.00	25.00	26.30	26.10	24.60	18.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.41	0.72	-4.12	3	78	2012-10-01 22:06:18	2005-01-14 17:15:22	6	1	8	0	0	79	0	39.20	84	36.06	CHANGED	CMGYDIECNEcLP.CCua..LECV+TSGY.WWYK+pYCRRK+	....CIGEGVPC.D....ENDP.RCCSG..LVCLKPTLHGIWYKSYYCYKK....	0	0	0	0
+7925	PF08093	Toxin_23		Magi 5 toxic peptide family	Lee SC	anon	Short protein clustering	Family	This family consists of toxic peptides (Magi 5) found in the venom of the Hexathelidae spider. Magi 5 is the first spider toxin with binding affinity to site 4 of a mammalian sodium channel and the toxin has an insecticidal effect on larvae, causing paralysis when injected into the larvae [1].	19.60	19.60	20.20	49.90	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.85	0.72	-4.01	5	8	2012-10-01 22:06:18	2005-01-14 17:16:09	6	1	5	3	0	9	0	29.20	50	36.68	CHANGED	uClLoph+CSSDK-CCGhTPsCshGlClPs	sClLophtCSsDK-CCGhTPsCshGlCsPp	0	0	0	0
+7926	PF08094	Toxin_24		Conotoxin TVIIA/GS family	Lee SC	anon	Short protein clustering	Family	This family consists of conotoxins isolated from the venom  of cone snail Conus tulipa and Conus geographus. Conotoxin  TVIIA, isolated from Conus tulipa displays little sequence  homology with other well-characterised pharmacological  classes of peptides, but displays similarity with conotoxin GS, a peptide from Conus geographus. Both these peptides  block skeletal muscle sodium channels and also share  several biochemical features and represent a distinct subgroup  of the four-loop conotoxins [1].	25.00	25.00	71.00	71.00	17.80	17.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-7.96	0.72	-4.35	2	2	2012-10-01 22:06:18	2005-01-14 17:16:32	6	1	2	2	0	4	0	31.50	63	98.44	CHANGED	uCSGRsSRCPP.CCMGLhCuRG...KCluhat-	uCSGRsSRCPP.CCMGLhCuRG...KCluhat-	0	0	0	0
+7927	PF08095	Toxin_25		Hefutoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of the hefutoxins that are found  in the venom of the scorpion Heterometrus fulvipes.  These toxins, kappa-hefutoxin1 and kappa-hefutoxin2,  exhibit no homology to any known toxins. The hefutoxins  are potassium channel toxins [1].	25.00	25.00	28.30	27.60	17.70	16.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.65	0.72	-6.82	0.72	-4.19	2	4	2009-01-15 18:05:59	2005-01-14 17:17:22	6	1	3	1	0	4	0	22.00	67	67.69	CHANGED	GHACYRNCWREGNDEETCKERC	GauCYRsCW+tGpDEETCKccC	0	0	0	0
+7928	PF08096	Bombolitin		Bombolitin family	Lee SC	anon	Short protein clustering	Family	This family consists of the bombolitin peptides that  are found in the venom of the bumblebee Megabombus  pennsylvanicus. Bombolitins are structurally and  functionally very similar. They lyse erythrocytes and  liposomes, release histamine from rat peritoneal mast  cells, and stimulate phospholipase A2 from different  sources [1].	25.00	25.00	26.50	26.50	17.30	16.10	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.39	0.74	-6.37	0.74	-3.51	2	4	2009-09-11 05:23:05	2005-01-14 17:17:58	6	1	1	0	0	4	0	17.00	77	100.00	CHANGED	.KIhDILAKLGKVLAHV	IKIpDILAKLGKVLAHV	0	0	0	0
+7929	PF08097	Toxin_26		Conotoxin T-superfamily	Lee SC	anon	Short protein clustering	Family	This family consists of the T-superfamily of conotoxins.  Eight different T-superfamily peptides from five Conus species were identified. These peptides share a consensus signal sequence, and a conserved arrangement of cysteine residues. T-superfamily peptides were found expressed in venom ducts of all major feeding types of Conus, suggesting that the T-superfamily is a large and diverse group of peptides, widely distributed in the 500 different Conus species [1].	25.00	25.00	27.80	27.80	12.90	11.70	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.18	0.73	-6.36	0.73	-3.17	2	2	2009-01-15 18:05:59	2005-01-14 17:18:32	6	1	1	0	0	2	0	11.00	91	100.00	CHANGED	FCCPhIRYCCW	FCCPhIRYCCW	0	0	0	0
+7930	PF08098	ATX_III		Anemonia sulcata toxin III family	Lee SC	anon	Short protein clustering	Family	This family consists of the Anemonia sulcata toxin III  (ATX III) neurotoxin family. ATX III is a neurotoxin  that is produced by sea anemone; it adopts a compact  structure containing four reverse turns and two other  chain reversals, but no regular alpha-helix or beta-sheet.  A hydrophobic patch found on the surface of the peptide may  constitute part of the sodium channel binding surface [1].	25.00	25.00	25.60	25.20	17.90	16.00	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.61	0.72	-4.12	2	7	2009-01-15 18:05:59	2005-01-14 17:18:57	6	1	3	1	0	7	0	24.30	76	41.98	CHANGED	poCCPC....YhuGCPWGQssa.pGCS	KSCCPC...hhpGs.CFWGQNCYPEGCS	0	0	0	0
+7931	PF08099	Toxin_27		Scorpion calcine family	Lee SC	anon	Short protein clustering	Family	This family consists of the calcine family of scorpion  toxins. The calcine family consists of Maurocalcine and  Imperatoxin. These toxins have been shown to be potent  effector of ryanodyne-sensitive calcium channel from  skeletal muscles. These toxins are thus useful for  dihydropyridine receptor/ryanodyne receptor interaction  studies [1,2].	25.00	25.00	55.50	55.10	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-7.87	0.72	-4.05	2	5	2012-10-01 22:06:18	2005-01-14 17:20:37	6	1	4	1	0	5	0	33.00	83	60.66	CHANGED	GDCLPHLKhCKtspDCCuKKCKRRGTNhEKRCR	.GDCLPHLKRCKENNDCCSKKCKRRGTNPEKRCR	0	0	0	0
+7932	PF08100	Dimerisation		Dimerisation domain	Bateman A	anon	Pfam-B_455 (Release 16.0)	Domain	This domain is found at the N-terminus of a variety of plant O-methyltransferases. It has been shown to mediate dimerisation of these proteins [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.30	0.72	-4.13	30	919	2012-10-04 14:01:12	2005-01-16 14:21:20	6	7	155	29	350	965	0	50.20	38	14.45	CHANGED	MsLKsAlELGlh-lltptG........phlosSElsupLs....hsPcusshlDRlLRlLu	...........MsLKsAl-LGls-hIpptG...........tshoh.s-ls.u...pLs..........hpPs...p.s...s..h.lcR.lhRlLs...........	0	22	202	291
+7933	PF08101	DUF1708		Domain of unknown function (DUF1708)	Mistry J, Wood V, Novatchkova M	anon	manual	Domain	This is a yeast domain of unknown function.	20.80	20.80	20.90	21.60	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.55	0.70	-5.64	19	144	2012-10-03 21:54:49	2005-01-24 15:49:59	6	4	126	0	112	156	0	412.60	32	37.80	CHANGED	pphstccV+pllHhhTtELKsRGhchsalhLPFRPcpssppl.sFlpphFshustt...hptctl.phlpps-shTLhpsLKah..WsRLPsu.lluW-sYppFKhtEp-psa.s+cAFlplhPpslsSsuHusIlYDFhDLLsuIuup....uphNthuGRKl.S+MuuhWAFs.spt.s...................su...FpsGhcpWtpuu-AhhHLhlAaLRShsPcs.pss....+LPpoLpsLL.sspYPPp.psshhpscoh.....pVPhlshps...SpsPapLLcRssc....st.t.Fps+-sashLpshF..phcssh...l.ptLocES+RlLcplo....osp........................................................................pshpsuWuc...................................................pphh...pscsshp.tpthSlscl-lcDaFhWsWhSSLusEpssp+KplFGRshllEscl...sG.pKWlVhpEps	...........................................................................p.pht.cclppll+hhTtELKt...Ru..h.................chPalh....LP..F....RPp......pssst....hcsFlpphF...ststtt..........ps.......ctl..p.c.l....p.h.s-sh...sLssslKah..Wu..RL.................P..........s.....G....l........lsW..-..u.....YphF..+htE....................p...................-upa.s+cAFt.shlPhslsS.su+.spIlaDFFDLlsulAA+.....u+tNuhuGRKL.S+hsuhWAFppscss.........................su...FpsuacsWhpAuDAhpHLhhAaLRS.....hsPcs.tss......pLPhoLpsLlptspY...........P........Pp.psshhpspoh...............pVsh.ls....ss...SssPatLLcRspp.........FphR-s.thLpph....phcssh.....pthocEs+RlLcslo....stp.................................................................................................................................................................................................pshsPuWAc...................................................................................p.th.....-pth.p.tp.h.sslsph-lDD.FhWsWhSSLusEpsst+KthFGRshllEs.l....u.t+WllhpE...................................................................................................................................................................................................................................................................................................................................................	0	32	63	99
+7934	PF08102	Antimicrobial_7		Scorpion antimicrobial peptide 	Lee SC	anon	Short protein clustering	Family	This family consists of antimicrobial peptides secreted by scorpions. Novel antimicrobial peptides have been isolated from scorpions, namely the opistoporin [1] and the pandinin [2]. These peptides form essentially helical structures and demonstrate high antimicrobial activity against Gram-negative and Gram-positive bacteria respectively.	25.00	25.00	27.30	46.10	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-7.94	0.72	-3.94	4	7	2009-01-15 18:05:59	2005-01-25 14:26:24	6	1	5	0	0	8	0	42.00	60	67.59	CHANGED	GKVWDWIKSsAKKlWNS-sVppLKspuLNAAKNaVAEKIGATP	.G.lWDhIKshAKKlWNS-ssppLKspALNAAKNaVAEKIGATP	0	0	0	0
+7935	PF08103	Antimicrobial_8		Uperin family	Lee SC	anon	Short protein clustering	Family	This family consists of the uperin family of antimicrobial peptides.  Uperin is a wide-spectrum antibiotic peptide isolated from the Australian toadlet, Uperoleia mjobergii. Being only 17 amino acid residues long, it is smaller than most other wide-spectrum antibiotic peptides isolated from amphibians. Uperin adopts a well-defined amphipathic alpha-helix with distinct hydrophilic and hydrophobic faces [1].	21.40	21.40	24.10	32.00	20.60	16.60	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.13	0.73	-6.25	0.73	-3.70	4	7	2009-01-15 18:05:59	2005-01-25 14:39:32	6	1	2	0	0	7	0	17.00	59	100.00	CHANGED	GVGDhhRKlVosIKNVV	GVhDhhRKlsoslKNlV	0	0	0	0
+7936	PF08104	Antimicrobial_9		Ponericin L family	Lee SC	anon	Short protein clustering	Family	This family consists of the ponericin L family of antimicrobial peptides that are isolated from the venom of the predatory ant Pachycondyla goeldii. Ponericin L family shares similarities with dermaseptins. Ponericin L may adopt an amphipathic alpha-helical structure in polar environments and these peptides exhibit a defensive role against microbial pathogens arising from prey introduction and/or ingestion [1].	25.00	25.00	59.50	59.40	20.60	17.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.73	0.72	-6.75	0.72	-4.15	2	2	2009-01-15 18:05:59	2005-01-25 14:40:06	6	1	1	0	0	2	0	24.00	96	100.00	CHANGED	LLKELWTKhKGAGKAVLGKIKGLL	LLKELWTKhKGAGKAVLGKIKGLL	0	0	0	0
+7937	PF08105	Antimicrobial10		Metchnikowin family	Lee SC	anon	Short protein clustering	Family	This family consists of the metchnikowin family of antimicrobial peptides from Drosophila.\	      metchnikowin is a proline-rich peptide whose expression is immune-inducible. Induction of the metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product. The metchnikowin peptide is unique among the Drosophila antimicrobial peptides in that it is active against both bacteria and fungi [1].	25.00	25.00	35.30	34.90	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.55	0.72	-4.34	2	13	2009-01-15 18:05:59	2005-01-25 14:40:48	6	1	12	0	7	13	0	51.90	66	99.70	CHANGED	MQLNLGAIFLALLGVMATATSVLAEPHRHQGPIFDTRPSPFNPNQPRPGPIY	MQLNL.GAI.FLALLGlhAsussl.huEsHR+QGPI.FDTRPSPFNPNQPR.P.GP.Y..	0	1	1	4
+7938	PF08106	Antimicrobial11		Formaecin family	Lee SC	anon	Short protein clustering	Family	This family consists of the formaecin family of  antimicrobial peptides isolated from the bulldog  ant Myrmecia gulosa in response to bacterial  infection. Formaecins are inducible peptide  antibiotics and are active against growing  Escherichia coli but were inactive against other  Gram-negative and Gram-positive bacteria. Formaecin peptides are 16 amino acids long, are rich in proline  and have N-acetylgalactosamine O-linked to a conserved  threonine [1].	25.00	25.00	41.80	41.80	14.90	14.30	hmmbuild  -o /dev/null HMM SEED	16	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.42	0.73	-6.40	0.73	-3.90	2	2	2009-09-10 15:42:18	2005-01-25 14:41:15	6	1	1	0	0	2	0	16.00	88	100.00	CHANGED	GRPNPVNsKPTPaPRL	GRPNPVNsKPTPaPRL	0	0	0	0
+7939	PF08107	Antimicrobial12		Pleurocidin family	Lee SC	anon	Short protein clustering	Family	This family consists of the pleurocidin family of antimicrobial peptides. Pleurocidins are found in the skin mucous secretions of the winter flounder (Pleuronectes americanus) and these peptides exhibit antimicrobial activity against Escherichia coli. Pleurocidin is predicted to assume an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defense [1].	21.10	21.10	22.00	21.30	19.20	17.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.17	0.72	-4.41	4	43	2009-01-15 18:05:59	2005-01-25 14:41:37	6	1	23	3	1	50	0	39.40	46	61.12	CHANGED	MKhsAhFLVLSLVVLMAEPGEuFltalh+GlhHuGKhIHGhl	MKhsAhFLVL.lVVLMAEPGEsha.t.plh+GhhHsG+h.I+th......................	1	0	0	1
+7940	PF08108	Antimicrobial13		Halocidin family	Lee SC	anon	Short protein clustering	Family	This family consists of the halocidin family of antimicrobial peptides. Halocidins are isolated from the haemocytes of the tunicate, Halocynthia aurantium. They are dimeric in structures which are found via a disulfide linkage between cysteines of two different- sized monomers. Halocidins have been shown to have strong antimicrobial activities against a wide variety of pathogenic bacteria and could be ideal candidates as peptide antibiotics against multidrug-resistant bacteria [1].	25.00	25.00	34.60	33.90	21.30	20.00	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.24	0.73	-6.32	0.73	-3.79	2	3	2009-01-15 18:05:59	2005-01-25 14:42:07	6	1	1	0	0	3	0	15.00	100	34.88	CHANGED	ALLHHGLNCAKGVLA	ALLHHGLNCAKGVLA	0	0	0	0
+7941	PF08109	Antimicrobial14		Lactocin 705 family	Lee SC	anon	Short protein clustering	Family	This family consists of lactocin 705 which is a bacteriocin  produced by Lactobacillus casei CRL 705. Lactocin 705 is a class IIb bacteriocin, whose activity depends upon the  complementation of two peptides (705-alpha and 705-beta) of  33 amino acid residues each. Lactocin 705 is active against  several Gram-positive bacteria, including food-borne pathogens  and is a good candidate to be used for biopreservation of  fermented meats [1].	21.00	21.00	89.90	89.90	19.50	18.30	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.39	0.72	-4.13	2	2	2009-01-15 18:05:59	2005-01-25 14:42:34	6	2	2	0	0	2	0	31.00	100	72.94	CHANGED	GMSGYIQGIPDFLKGYLHGISAANKHKKGRL	GMSGYIQGIPDFLKGYLHGISAANKHKKGRL	0	0	0	0
+7942	PF08110	Antimicrobial15		Ocellatin family	Lee SC	anon	Short protein clustering	Family	This family consists of the ocellatin family of antimicrobial peptides. Ocellatins are produced from the electrical-stimulated skin secretions of the South American frog, Leptodactylus ocellatus.  The family consists of three structurally related peptides, ocellatin 1, ocellatin 2 and ocellatin 3.  These peptides present hemolytic activity against human erythrocytes and are also active against Escherichia coli [1].	22.70	22.70	23.10	36.00	21.00	22.60	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.27	0.73	-6.55	0.73	-3.64	3	5	2009-01-15 18:05:59	2005-01-25 14:43:01	7	1	3	0	0	5	0	19.00	62	81.20	CHANGED	VLDILKGAAKDLLAHlAsK	VLDILKGAAKDLLAHlAsK	0	0	0	0
+7943	PF08111	Pea-VEAacid		Pea-VEAacid family	Lee SC	anon	Short protein clustering	Family	This family consists of the PEA-VEAacid neuropeptides  family. These neuropeptides are isolated from the  abdominal perisympathetic organs of the American cockroach.  These peptides are found together with Pea-YLS-amide and Pea-SKNacid, giving a unique neuropeptide pattern in abdominal  perisympathetic organs. The functions of these neuropeptides  are unknown [1].	25.00	25.00	44.20	44.10	23.00	19.50	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.31	0.74	-6.14	0.74	-3.46	2	2	2009-01-15 18:05:59	2005-01-25 14:45:27	6	1	1	0	0	2	0	15.00	93	93.75	CHANGED	LsLTPGSHVDSYVEA	LsLTPGSHVDSYVEA	0	0	0	0
+7944	PF08112	ATP-synt_E_2		ATP synthase epsilon subunit	Lee SC	anon	Short protein clustering	Family	This family consists of epsilon subunits of the ATP  synthase. The ATP synthase complex is composed of an  oligomeric transmembrane sector (CF0), and a catalytic  core (CF1). CF1 is composed of 5 subunits, of which  the epsilon subunit functions as a potent inhibitor of  ATPase activity in both soluble and bound CF1. Only  when the epsilon inhibition is disabled is high  ATPase activity detected in ATPase [1]	25.00	25.00	25.30	25.30	24.70	21.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.81	0.72	-3.90	2	15	2009-01-15 18:05:59	2005-01-25 14:48:08	6	1	15	0	4	6	0	50.40	71	92.87	CHANGED	Msp......DKYlpIL+spL-pKKsElLppINMEYEKhLKpRLspL-clKtplLKE	.....MDQ......DKYLQILRSSLEEKKSEILKNVNAEYEKLLKNRLNQLDEVKRKVLKE	0	1	1	3
+7945	PF08113	CoxIIa		Cytochrome c oxidase subunit IIa family	Lee SC	anon	Short protein clustering	Family	This family consists of the cytochrome c oxidase subunit IIa family.  The bax-type cytochrome c oxidase from Thermus thermophilus is known as a two subunit enzyme. From its crystal structure, it was discovered that an additional transmembrane helix 'subunit IIa' spans the membrane.  This subunit consists of 34 residues forming one helix across the membrane. The presence of this subunit seems to be important for the function of cytochrome c oxidases [1].	20.70	20.70	23.20	22.60	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.39	0.72	-4.23	2	13	2009-01-15 18:05:59	2005-01-25 14:49:03	6	1	13	27	5	11	0	34.30	59	88.49	CHANGED	MEEKPKGALAVILVLTLTILVFWLGVYAVFFARG	.......MEEK...PpGALuVIhVLTlTILVFWhGVaAlFhARG.	1	1	4	5
+7946	PF08114	PMP1_2		ATPase proteolipid family	Lee SC	anon	Short protein clustering	Family	This family consists of small proteolipids associated with the plasma membrane H+ ATPase. Two proteolipids (PMP1 and PMP2) are associated with the ATPase and both genes are similarly expressed in the wild-type strain of yeast with no modification of the level of transcription of one PMP gene is detected in a strain deleted of the other. Though both proteolipids show similarity with other small proteolipids associated with other cation -transporting ATPases, their functions remain unclear [1].	22.10	22.10	22.30	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.22	0.72	-4.47	2	29	2009-01-15 18:05:59	2005-01-25 14:51:50	6	1	21	0	18	21	0	39.90	63	68.42	CHANGED	M...TLPGGVILVFILVGLACIAIIuTIIYRKWQARQRGLQRF	...........LPGGVILVFILVGLAsIAIluTIIYRKWQARQRuLQRF.....	0	3	8	16
+7947	PF08115	Toxin_28		SFI toxin family	Lee SC	anon	Short protein clustering	Family	This family consists of the SFI family of spider toxins. This family of toxins might share structural, evolutionary and functional relationships with other small, highly structurally constrained spider neurotoxins. These toxins are highly selective agonists/antagonists of different voltage-dependent calcium channels and are extremely valuable reagents in the analysis of neuromuscular function [1].	25.00	25.00	39.90	39.90	23.40	18.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.96	0.72	-4.29	2	10	2009-01-15 18:05:59	2005-01-25 14:53:16	6	1	1	0	0	10	0	33.30	79	79.10	CHANGED	+psMsDEoVCYIpspNsssGpCLp.pusaAcPWEh	.KECMsDGTVCYIHNHNDCCGSCLC.NGPlARPWEM.	0	0	0	0
+7948	PF08116	Toxin_29		PhTx neurotoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of PhTx insecticidal neurotoxins that are found in the venom of Brazilian, Phoneutria nigriventer. The venom of the Phoneutria nigrivente contains numerous neurotoxic polypeptides of 30-140 amino acids which exert a range of biological effects.  While some of these neurotoxins are lethal to mice after intracerebroventricular injections, others are extremely toxic to insects of the orders Diptera and Dictyoptera but had much weaker toxic effects on mice [1].	25.00	25.00	68.20	68.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.79	0.72	-4.16	4	6	2009-01-15 18:05:59	2005-01-25 14:55:43	6	1	4	0	0	6	0	31.00	72	96.88	CHANGED	AFC+aNGQQCTSDGQCCpG+ChTAFhG+ICM	sFCRaNGQQCTSDGQCCaG+C+TAFhG+ICM	0	0	0	0
+7949	PF08117	Toxin_30		Ptu family	Lee SC	anon	Short protein clustering	Family	This family consists of toxic peptides that are  isolated from the saliva of assassin bugs. The  saliva contains a complex mixture of proteins  that are used by the bug either to immobilise  the prey or to digest it. One of the proteins (Ptu1)  has been purified and shown to block reversibly the  N-type calcium channels and to be less specific for  the L- and P/Q- type calcium channels expressed in  BHK cells [1].	24.50	24.50	24.90	79.10	24.20	23.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.03	0.72	-3.92	2	3	2012-10-01 22:06:18	2005-01-25 14:56:59	6	1	3	2	0	3	0	34.70	57	99.05	CHANGED	A-cDCls.Gu.ChGpsK.CCp.+shC..YAN+C..l	AD-DCLPRGSKCLGENKQCCc.+TTCMFYANRCVGl.	0	0	0	0
+7950	PF08118	MDM31_MDM32		Yeast mitochondrial distribution and morphology (MDM) proteins 	Mistry J, Wood V	anon	Pfam-B_37122 (release 16.0)	Family	Proteins in this family are yeast mitochondrial inner membrane proteins MDM31 and MDM32.\	      These proteins are required for the maintenance of mitochondrial morphology, and the stability of mitochondrial DNA [1].	18.20	18.20	38.10	18.40	17.20	17.70	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.66	0.70	-6.04	5	247	2009-01-15 18:05:59	2005-01-25 16:36:47	6	4	139	0	186	252	0	358.20	32	76.81	CHANGED	cRDQLLAQAoNhauRLRIRLKWhLKRS.NRPFNTDDISAFlSWlLVSNsLLlFLuTTTFlSLVIYLhNTVFAQEYVAcKlGNFLTKNSALTVVFESAIVPDWSSGKISF+KVFVSRRPKpscuFoKGSQ+EAsERAKLALSEsLLVscE-FDDGNYTQFDLTIDQV-ISLSLsKWINGKGhlDEVpINGLRGVVDRTHVaWKssDDARNYKNVHQPGDFEISsF+MNDVLFTLYQPuGFRPFpVSIFNCELPQLRKHWLFYDFLNANsMSGoYDNSMFTIHKKa+pcDhsc...psSsSssW+KVTRMRVDSLNIDHLNAGlEGPFGWITSGKVDMIGDVLLP--NtDslsLSELLTlIuDRIlKEA+RYpNhlPtpKs-pPDI..........DlccYFVMDFoLRLNNVRAcVPLFTPELSYINNALIRPIVGYINSKRTYIPI+CRVVKNLsDFuGSWTIYDShLMDDLSAEVYDAFA-YVAD-EpRslRMKRVGFWSLQLLlQLILhSLGAIA	.........................................................+tphL..spshhp+hhlph+Wh.h+s..Rsas.--..h..sshhSWhhhuphhhhhluTTTFhuhhhh.h....N.....oh....p-hls...t.h.l.....uphhs......t...hph.hpp.shhst.ht.....pshI.hp.ps.l...................................................................................................................................................................................................................p..hhpa-lplpplsloLSh.pWhpGpGhlpphpl.GlRG...........hl...........shp.................p..h..........t..................s..............h.....t.h...hp.....hp......s.......sa.EhpphphpDhhhplhpst.s.h.ps.....hphSIashclspLRtpalhhDhhsAp.hsGshssShFol.....H.pQ...h.......t.........t..........................................a.pp.........hsRhRlDslplscLp..t.....sh...p.ushsWIhpGpl-hluDlhhPt.p....t..p...................t.....th....h..........h............................................................................................................................p.....hhh.hshplph.sl+A.hP................ths.....hhs.s.....l.....RslluahN............s...p....pp.....l.lpsph...htphts..ph.pshhhp.h..th...................Ytth...l...pt...p..p.c....Ws.p..............tt....................................................................	0	51	109	166
+7951	PF08119	Toxin_31		Scorpion acidic alpha-KTx toxin family	Lee SC	anon	Short protein clustering	Family	This family consists of acidic alpha-KTx short chain scorpion toxins. These toxins named parabutoxins, block voltage-gated K channels and have extremely low pI values. Furthermore, they lack the crucial pore-plugging lysine. In addition, the second important residue of the dyad, the hydrophobic residue (Phe or Tyr) is also missing [1].	25.00	25.00	90.40	90.30	22.30	21.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-8.05	0.72	-4.42	2	3	2009-01-15 18:05:59	2005-01-25 16:49:08	6	1	2	0	0	3	0	36.70	93	100.00	CHANGED	DEEPKEoCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD	DEEPKETCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD	0	0	0	0
+7952	PF08120	Toxin_32		Tamulustoxin family	Lee SC	anon	Short protein clustering	Family	This family consists of the tamulustoxins which are  found in the venom of the Indian red scorpion (Mesobuthus  tamulus). Tamulustoxin shares no similarity with other  scorpion venom toxins, although the positions of its six  cysteine residues suggest that it shares the same  structural scaffold. Tamulustoxin acts as a potassium channel  blocker [1].	25.00	25.00	97.40	97.30	16.70	16.70	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.97	0.72	-4.35	2	2	2009-01-15 18:05:59	2005-01-25 16:50:44	6	1	1	0	0	2	0	35.00	97	100.00	CHANGED	RCHFVlCTTDCRRNSPGTYGECVKKEKGKECVCKS	RCHFVlCTTDCRRNSPGTYGECVKKEKGKECVCKS	0	0	0	0
+7953	PF08121	Toxin_33		Waglerin family	Lee SC	anon	Short protein clustering	Family	This family consists of the lethal peptides (waglerins)  that are found in the venom of Trimeresurus wagleri.  Waglerins are 22-24 residue lethal peptides and are  competitive antagonist of the muscle nicotinic receptor  (nAChR). Waglerin-1 possesses a distinctive selectivity  for the alpha-epsilon interface binding site of the mouse  nAChR [1].	25.00	25.00	25.70	57.80	24.10	15.40	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.73	0.72	-6.95	0.72	-4.35	2	2	2009-01-15 18:05:59	2005-01-25 16:51:09	6	1	1	0	0	2	0	22.00	95	91.67	CHANGED	GGKPDLRPCaPPCHYIPRPKPR	GGKPDLRPCaPPCHYIPRPKPR	0	0	0	0
+7954	PF08122	NDUF_B12		NADH-ubiquinone oxidoreductase B12 subunit family	Lee SC	anon	Short protein clustering	Family	This family consists of the NADH-ubiquinone  oxidoreductase B12 subunit proteins. NADH is the  central source of electrons in the mitochondrial  and bacterial respiration. NADH-ubiquinone  oxidoreductase is involved in the transfer of  electrons from NADH to the electron transport  chain. This oxidation of NADH is coupled to  proton transfer across the membrane, generating  a proton motive force that is utilised for the  synthesis of ATP. The function of this subunit is unclear [1].	22.70	22.70	22.70	23.40	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.98	0.72	-4.23	13	205	2009-01-15 18:05:59	2005-01-25 17:17:10	7	3	190	0	146	193	0	56.50	39	58.04	CHANGED	LRDPWuRNEAWRY.hssFuppho.hhsshF+GFtaG.FuAFVlslulE.....ahhtssc+sp.H	....+DPWtRsEAWRY..pGsFu.c....hs......hhcshh.....Ghshu.hs.AFs.shluhE......ah.l..p.sp..c+p.................	0	49	73	111
+7955	PF08123	DOT1		Histone methylation protein DOT1 	Mistry J, Wood V	anon	Pfam-B_12064 (release 16.0)	Domain	The DOT1 domain regulates gene expression by methylating histone H3 [1]. H3 methylation by DOT1 has been shown to be required for the DNA damage checkpoint in yeast [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.18	0.71	-5.02	11	554	2012-10-10 17:06:42	2005-01-25 17:38:26	8	19	328	15	391	1008	656	161.00	26	26.32	CHANGED	YsRuV.PcspcL+.cYcuFSspVYGELhPsFloslhpcssLsssclFhDLGSGVGNsVlQAALEhGCchSaGCElM-sASclAEtQhcEhcp+hphaGh+hsplcat.+tSFlsN-clcpllspsDVlLVNNFhFDspLNppl.pchltsLKsGsKIISLKshtsssap.Is.csh-sIhshL+Vpchshscs.SVSWTsps.ssYYISTl	..............................................................sYGEh...............t...hl.sp....l...h....p....p.h....p......l...p.p..........s..s..........l.FlDLGSGlGp...ll............hQsA.hph.s.sc........s..hGlEh.h........pp.h..s.p..h...A.........pt........t..t..h..p....t.........h.h....t......h.h...s....h..t......h.....php....h...ps....s..hh.p....t.........h.................h.......tp...ss..llhhN..s...........h..h......F..s...........p.l.t....tl.....p.h.h.......p.h...t.....G.sp.l.l.o...p...hh........................................................................................................................................................................................................................................................	1	140	218	354
+7956	PF08124	Lyase_8_N		Polysaccharide lyase family 8, N terminal alpha-helical domain	Mistry J	anon	Pfam-B_2438 (release 16.0)	Family	This family consists of a group of secreted bacterial lyase enzymes EC:4.2.2.1 capable of acting on hyaluronan and chondroitin in the extracellular matrix of host tissues, contributing to the invasive capacity of the pathogen.	24.00	24.00	24.90	24.20	21.40	23.90	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.96	0.70	-5.56	26	980	2012-10-02 15:11:41	2005-01-31 09:02:22	6	52	764	44	96	695	5	312.20	30	35.54	CHANGED	Wtshl......hGsp.hsssssshtshhpphsppup.p.hsshp...psspshLWpcls........tpssoupl..Tssap+LpphApAappPsSshapssslhssIhcuLcahppphYssspp.................phG.NWWcWpIGsPpulsshLlLha-tlo...psclssYssslc+FsP-P.............sht....hpuTGANpsDhupshllcGlLpcDssclppuhcuLss........VashVspG......DGFYpDGSaIQH...........sslsYTGuYGsVLlcGlupLhsllpsosaslss.phsslachlccuahPllhcGtMMDhlRGRuISRtssp.........s+..stGtsllpullhl.uphussspp..tchpuhlKs	................................................................................W.sh.hG..p.ac..pps.phtphhpt..h-p.....c.s...t.....p.....hlpshpp....pss.Rs..h..L.Wpshp...............................ppS.ush....Tpoa+plcchApsh..p....sP.....s....op..h.a..p-....pplhptlh-ul-ah.pcphYs.s..p.s......................hu..NWWDaE.........IGsP+ulssTLhLhp...-.h..ho..............s-.chpp..ao.ss.Icp...FsPDs................tthh..ohs....shtu.......pG..uNhlDhu..+s..hlhpull....p.c.......Ds.p.p......lpp...ulc...ulsp...............V..F..ph...Vs..pu...................-.GFYpDGSaIpH..............ssVsYTG.uYGs.V.L...lcGluplhsllpt.....T....tas..h..s..spp..pslhpal-c..u.FhPll.hp.G.....ch.....h.D.h.s.RGRu.ISRtspp.........u+.....stuh.plhpulhhl.uc.h..sppp..tchpphlK..................................................................................	0	54	80	93
+7957	PF08125	Mannitol_dh_C		Mannitol dehydrogenase C-terminal domain	Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.80	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.61	0.70	-5.20	16	5053	2012-10-02 19:36:47	2005-01-31 18:33:56	8	18	2344	4	791	3180	477	232.20	31	52.45	CHANGED	ppVuFPsshVDRIVPt...........thuhcDPhsVssEPFhpWVlEcshhpG.ss...hchsGsphVsclpPY.EhKLhhLNuuHuslAYlGaLtGhphlcEuhpDtplpthlcshhtEphtsllshh...sts-LpsYtspllpRFpNPhIpDplpRluhs.....PhRhLsshcchlt...shhchhshs.tsahphlpGlstshphhp.sDsputplpt..........hhspcpspshLu.hshhtt-h.pssph	..............................................pVsFssohVDRIVPs...........s....t...........h...............h....................p...........t...........h.....G.h.p..D............s............h.........................V............s............s............E......s.F..t..........p............W....VlE..c.s.h..h.....t.G...p..s...............h..c.h.....s..G....sp....h..V...s...D...l...h...PacEh..KL.t.h.LNuuHoh.lA....Yl...Gh....L...u..G...a...p....pIt-shp.D.sth.......cthsc.t...hhh...c.-tt...s.h..l.ph........sss...-......h.psYt.p.....p.l.l.t.RF..pN...P...hlccpshplAhss.pKh..P..h..RhLssh.c.thlpt....t.....s..........h....t....h..L....s.....h.....u....Au.a....h.pa...l..........p......G..........l...........s..........t............t.........t.........p..........h.........h.s..........s..D..s.....h......phtp....................h...s...p...p.t.....sp....s....h....Lu.....shhsts.......h..................................................................	1	196	439	611
+7958	PF08126	Propeptide_C25		Propeptide_C25	Mistry J	anon	Rawlings N	Motif	This is found at the N terminal end of some of the members of the C25 peptidase family (PF01364).  Little is known about the function of this motif.	20.30	20.30	22.30	20.70	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.23	0.71	-5.32	4	56	2009-01-15 18:05:59	2005-02-01 17:12:27	6	18	27	0	24	60	111	185.60	21	14.11	CHANGED	QsschttsPs....lphltssppSho+lpFc..hsplpFTpVpTpcG..shQssohstusshuEhGpPpLPlLp+.lAVs-..Ttsh+Vclhoochh-ppsl...hlsPopssh.+sEsP-plPY......l.upuYupstFhPuElsslspshhhRsVRhtsVshsPlQYNPVsppL+lhscIpVsVS.su.....ppspshhshhcsSsFssFEssYKphF	......................................................................................................................tts.....hp..hp..h.th.htphp.h.tt..hht.hshst.sh.....hsch.G.PpLPh.hpp.lulPs...s.hp..hpVps.ss.sp.h..hph.psh....hlhP.sps..h.csp.s..Pp...p.lsa.........hpspsYspspaaPsplsplspshhhRsh+stslshtPlQYNPVoppL+l....hsplplplohpu........tpt.t................................................	0	17	22	23
+7959	PF08127	Propeptide_C1		Peptidase family C1 propeptide	Mistry J	anon	Rawlings N 	Motif	This motif is found at the N terminal of some members of the Peptidase_C1 family (Pfam:PF00112) and is involved in activation of this peptidase [1].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.83	0.72	-4.33	60	407	2009-01-15 18:05:59	2005-02-02 09:21:42	8	5	183	5	123	418	2	41.70	37	13.35	CHANGED	LS--hIphINp.p.ssTWKAG+N..F.tshohspl+pLhGs.h.sss	.....LS--hlshINc.p.ssTW+AG+N...F...shs....hs.h+pLhGs.hhps...........	0	61	73	99
+7961	PF08129	Antimicrobial17		Alpha/beta enterocin family	Lee SC	anon	Short protein clustering	Family	This family consists of the alpha and beta enterocins and  lactococcin G peptides. These peptides have some antimicrobial  properties; they inhibit the growth of Enterococcus spp. and a  few other gram-positive bacteria. These peptides act as pore- forming toxins that create cell membrane channels through a  barrel-stave mechanism and thus produce an ionic imbalance in  the cell. These family of antimicrobial peptides belong to the  class II group of bacteriocin [1].	25.00	25.00	26.80	26.50	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.73	0.72	-4.19	2	7	2012-10-02 23:56:30	2005-02-22 13:49:07	6	1	4	2	0	8	0	46.40	57	90.78	CHANGED	MKQYKVLNEKEMKKsIGGESVFSKIGNAVGPAAYWILKGLGNMSDVNQADRINRKKH	.......K.LsEKEh+pslGG....scIGpulG.sAYWlhKuhGNMSDVNQAsRINRKK.t..............	0	0	0	0
+7962	PF08130	Antimicrobial18		Type A lantibiotic family	Lee SC	anon	Short protein clustering	Family	This family consists of the type A lantibiotic peptides. Both Pep5  and epicidin-280 are ribosomally-synthesised antimicrobial peptides  produced by Gram-positive bacteria that are characterised by the  presence of lanthionine and/or methyllanthionine residues. The  lantibiotics family has a highly specific activity against multi- drug resistant bacteria and has potential to be utilised in a wide range of medical applications [1,2].	25.00	25.00	31.80	31.60	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.98	0.72	-4.09	2	6	2009-09-11 06:04:39	2005-02-22 13:49:58	6	1	4	0	0	4	0	53.30	58	100.00	CHANGED	McNpKsLFDLEIKK-s.pNssELEsQohGPAI+Aohp.C....KATRhhTVSCK.KssCp	M...NKELFDLDINK.pMEsPTEMTsQThGTslKVS+ulCK...puTCIsTISCo...NC.K	0	0	0	0
+7963	PF08131	Defensin_3		Defensin-like peptide family	Lee SC	anon	Short protein clustering	Family	This family consists of the defensin-like peptides (DLPs) isolated from platypus venom. These DLPs show similar three-dimensional fold to that of beta-defensin-12 and sodium-channel neurotoxin Shl. However the side chains known to be functionally important to beta-defensin-12 and Shl are not conserved in DLPs. This suggests a different biological function. Consistent with this contention, DLPs have been shown to possess no anti-microbial properties and have no observable activity on rat dorsal-root-ganglion sodium-channel currents [1].	17.70	17.70	17.70	18.00	17.50	17.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.20	0.72	-3.98	2	9	2012-10-01 20:50:19	2005-02-22 13:51:53	6	1	3	4	8	11	0	38.40	44	68.38	CHANGED	ac.psC.ShsGVCRcKsphNC+.hhhs.C.NcpQKCCch	.......ptCpshuGVCRcKss+NC+sIhhs.CcNRNp+CCc...	1	0	0	6
+7964	PF08132	AdoMetDC_leader		S-adenosyl-l-methionine decarboxylase leader peptide	Lee SC	anon	Short protein clustering	Family	This family consists of the S-adenosyl-l-methionine decarboxylase (AdoMetDC) leader peptides. AdoMetDC is a key regulatory enzymes in the biosynthesis of polyamines. All expressed plant AdoMetDC mRNA 5' leader sequences contain a highly conserved pair of overlapping upstream ORFs (uORFs) that overlap by one base. Sequences of the small uORFs are highly conserved between monocot, dicot and gymnosperm AdoMetDC mRNA species, suggesting a translational regulatory mechanism [1].	25.00	25.00	55.60	55.00	17.20	17.00	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.69	0.72	-4.03	3	44	2009-01-15 18:05:59	2005-02-22 13:56:19	6	3	24	0	23	40	0	50.70	78	40.31	CHANGED	MESKGGKKKSSSSSSpsoLFFEAPLGYSIEDVRPNGGIKKFRSAAYSNCo+KPS	........MESKGGKKKSSSSsS...LhYEAPLGYSIEDVRPsGGIKKFRSAAYSNCu++PS.....	0	4	18	23
+7965	PF08133	Nuclease_act		Anticodon nuclease activator family	Lee SC	anon	Short protein clustering	Family	This family consists of the anticodon nuclease activator proteins.  Pre-existing host tRNAs are reprocessed during bacteriophage T4 infection of certain Escherichia coli strains. In this pathway, tRNA(Lys) is cleaved 5' by the anticodon nuclease to the wobble base and is later restored in polynucleotide kinase and RNA ligase reactions [1].	25.00	25.00	36.50	36.30	18.50	16.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-7.23	0.72	-4.45	2	15	2009-01-15 18:05:59	2005-02-22 13:59:57	6	1	14	0	0	9	0	25.40	82	96.21	CHANGED	MSNFHNEHVMQFYRNNLKshGlhGhp	.MSNFHNEHVMQFYRNNLKTKGVFGRp..	0	0	0	0
+7966	PF08134	cIII		cIII protein family	Lee SC	anon	Short protein clustering	Family	This family consists of the cIII family of  regulatory proteins. The lambda CIII protein  has 54 amino acids and it forms an amphipathic  helix within its amino acid sequence. Lambda  cIII stabilises the lambda cII protein and the  host sigma factor 32, responsible for transcribing  genes of the heat shock regulon [1]. 	25.00	25.00	64.30	64.20	23.90	23.20	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.28	0.72	-4.36	3	42	2009-01-15 18:05:59	2005-02-22 14:20:08	6	1	42	0	2	15	0	43.80	89	98.29	CHANGED	MMHFQLAGSGVMSAFYPHESELSRRVKQLIRAAKKQLEALCAMK	MMHFQLAGSGVMSAFYPHESELSRRVKQLIRAAKKQLEALCAMK....	0	0	0	1
+7967	PF08135	EPV_E5		Major transforming protein E5 family	Lee SC	anon	Short protein clustering	Family	This family consists of the major transforming proteins (E5)  of the bovine papilloma virus (BPV). The equine sarcoid is  one of the most common dermatological lesion in equids. It is  a benign, locally invasive dermal fibroblastic lesion and  studies have shown an association of the lesions with BPV. E5  is a short hydrophobic membrane protein localising to the Golgi  apparatus and other intracellular membranes. It binds to and  constitutively activates the platelet-derived growth factor-beta  in transformed cells. This stimulation activates a receptor  signaling cascade which results in an intracellular growth  stimulatory signal [1].	25.00	25.00	37.10	36.90	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.50	0.72	-3.97	3	23	2009-01-15 18:05:59	2005-02-22 14:21:20	6	1	6	0	0	22	0	42.30	82	99.79	CHANGED	Msa.GLLLFLGLTFAlQLLLLVFLLFFFLVWWDQFGCRC-Gh.L	MPNLWFLLFLGLVAAMQLLLLLFLLLFFLVYWDHFECSCTGLPF.	0	0	0	0
+7968	PF08136	Ribosomal_S22		30S ribosomal protein subunit S22 family	Lee SC	anon	Short protein clustering	Family	This family consists of the 30S ribosomal proteins subunit  S22 polypeptides. This polypeptide is 47 amino acids in length  and has a molecular weight of about 5 kDa. The S22 subunit is a  component of the stationary-phase-specific ribosomal protein and  is assembled in the ribosomal particles in the stationary phase.  This subunit along with other stationary-phase-specific ribosomal  proteins result in compositional changes of ribosomes during the  stationary phase. The significance of this change is not clear as  yet [1].	25.00	25.00	26.00	25.30	24.00	23.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.05	0.72	-3.81	3	402	2009-12-01 13:51:23	2005-02-22 14:28:17	6	1	400	0	14	34	0	44.90	88	97.59	CHANGED	MKSNRQARHILGLDYKLSNQRKVVIEGDsEoVVTHATGRKRHA-K	..MKSNRQARHILGLDHKISN.QRKIVTEGDKSSVV..N..N..PTGRKRPAEK............	0	1	2	8
+7969	PF08137	DVL		DVL family	Lee SC	anon	Short protein clustering	Family	This family consists of the DVL family of proteins.  In a gain-of-function genetic screen for genes that influence fruit development in Arabidopsis, DEVIL (DVL) gene was identified. DVL is a small protein and overexpression of the protein results in pleiotropic phenotypes featured by shortened stature, rounder rosette leaves, clustered inflorescences, shortened pedicles, and siliques with pronged tips. DVL family is a novel class of small polypeptides and the overexpression phenotypes suggest that these polypeptides may have a role in plant development [1].	19.60	19.60	19.70	22.30	18.50	19.20	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.20	0.72	-6.21	0.72	-4.48	20	182	2009-09-11 09:54:20	2005-02-22 14:32:13	7	4	18	0	129	166	0	19.00	66	23.47	CHANGED	KEQRuRhYIlRRClsMLlC	.KEQRARhYIlRRCVsMLlC...	0	24	81	101
+7970	PF08138	Sex_peptide		Sex peptide (SP) family	Lee SC	anon	Short protein clustering	Family	This family consists of Sex Peptides (SP) that are found in Drosophila. On mating, Drosophila females decreases her remating rate and increases her egg-laying rate due, in part, to the transfer of SP from the male to the female. SP are found in seminal fluids transferred from the male to the female during mating. The male seminal fluid proteins are referred to as accessory gland proteins (Acps). The SP is one of the most interesting Acps and plays an important role in reproduction [1].	25.00	25.00	53.90	53.80	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.08	0.72	-4.12	5	23	2009-01-15 18:05:59	2005-02-22 14:41:42	6	1	10	1	2	24	0	52.70	57	99.51	CHANGED	M+sPl.LhLllL..LlGlAhuh...hscRsc.....susIhGP+DRcKWCRLNLGPAWGGRsC	....MKs.hhhLlLVh..lLGLs.uhpWPhs++ss.....+hsI.SPpsR-KWCRLNLGPAWGGR.C	0	2	2	2
+7971	PF08139	LPAM_1	VirB;	Prokaryotic membrane lipoprotein lipid attachment site	Lee SC, Bateman A	anon	Short protein clustering	Motif	In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.71	0.73	-7.05	0.73	-3.54	71	711	2012-10-01 23:27:00	2005-02-22 14:43:14	7	16	567	0	60	226	22	24.40	62	12.78	CHANGED	M...................................++hhhhhhhhh...LuuCuo	.....................................................MhKKILFPLlALFh..LAGCAp.	0	6	22	43
+7972	PF08140	Cuticle_1		Crustacean cuticle protein repeat	Lee SC	anon	Short protein clustering	Family	This family consists of the cuticle proteins from the Cancer  pagurus and the Homarus americanus. These proteins are isolated  from the calcified regions of the crustacean and they contain two  copies of an 18 residue sequence motif, which thus far has been  found only in crustacean calcified exoskeletons [1].	21.40	21.40	21.40	26.00	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-7.95	0.72	-4.13	38	90	2009-01-15 18:05:59	2005-02-22 14:44:51	6	6	6	0	0	82	0	40.00	45	71.21	CHANGED	GsSGllhsDGp.hQhstsh..sl..lLhGPSGhVhusGcslQh	.....G.SGllhsDGp.hQhstsh..sl..llhGPSGhVhusGcNlQh......	0	0	0	0
+7973	PF08141	SspH		Small acid-soluble spore protein H family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins  (SASP) of the H type (sspH). SspH are unique to spores of Bacillus  subtilis and are expressed only in the forespore compartment  during sporulation of this organism. The sspH genes are  monocistronic and are recognised by the forespore-specific  sigma factor for RNA polymerase - sigma-G. The specific role  of this protein is unclear but is thought to play a role in  sporulation under conditions different from that of the common laboratory tests of spore properties [1].	25.00	25.00	51.10	51.00	21.30	17.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.72	0.72	-3.92	20	329	2009-01-15 18:05:59	2005-02-22 14:48:28	7	1	194	0	59	184	1	57.70	46	94.31	CHANGED	M.-spRAKcIlsSsshlsVoYpGsPVaI-cVs.EpscsApla.l.ssspccpcVslssLcE	..MslpRAKpIhsSspphsVoa.pG.hPVaIppVD.EpspsAplYpl.sN.PscchpVsVssLcE.......	0	19	39	43
+7974	PF08142	AARP2CN		AARP2CN (NUC121) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is the central domain of AARP2.  It is weakly similar to  the GTP-binding domain of elongation factor TU [1].	21.50	21.50	21.50	25.10	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.67	0.72	-4.45	73	707	2009-01-15 18:05:59	2005-02-22 15:35:56	7	33	318	0	470	699	8	82.40	35	9.33	CHANGED	-htNLhRhlssh+..+slsWRss+sYllu-chch...hsssp..t................................plslhGalRGss.hss..sphVHIsGhGDFplspI.ptlsDPs	......................................EhpNLhRhlsshK..+.slpW..Rss+sYlLu-chc.....hsssppht............................................tslslhGYlRGps....Lps.....s..........phVHIsGhG..DFplspl.phhsDP............................	0	170	265	390
+7975	PF08143	CBFNT		CBFNT (NUC161) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in proteins of CARG-binding factor A-like proteins [1].	21.70	21.70	21.80	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.89	0.72	-2.88	16	125	2009-01-15 18:05:59	2005-02-22 15:43:46	6	4	36	2	37	95	0	66.10	44	21.96	CHANGED	MS...E-Qhhpss..st.....sGpcuss-ppus...tshtGs.u..............................sussssAEGspI-ASKNEEDsGK	.........................MS...EpQ.htss..st.....sG..uss-tpush..ssttussu....................uG...tsusssss...sGssstAEGspIsASKNEEDtGK.	0	2	7	16
+7976	PF08144	CPL		CPL (NUC119) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is fund in Penguin-like proteins associated  with Pumilio like repeats [1].	20.70	20.70	20.70	21.40	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.72	0.71	-4.36	8	270	2009-01-15 18:05:59	2005-02-22 15:44:06	6	5	231	0	193	266	1	141.50	26	20.63	CHANGED	lssKYGRKVLLYLLuPRDssHFhPEIIclLccGD....sNAaSKKDsplRR+ELLEuISPsLLchls-cup-llhDpussllVuDILssssGDspsshs.AlAplAsp-h.suuh-G-hHIuccPAGHhsLKhLIpQD+chtEsGKEspFu+s	.....................................h..spauR+slLY.Lls.s..t......sstah...s......s...p....h...l.p.h.L.pcsc............tsspSKKDspl...RRpELl..c...uho...P...s....LLphl....sp.....p.....s.........p.........pllp.s....sh....us.hls.-........l.Lh..........s......u.s..........G...........-.p.p..s.s.hp....A.lAph.s.....sp..p.........................t..............t..........t..t...p..................+hh.pp.shuthhL.KhLlptsp.......................................................................................	0	59	99	157
+7977	PF08145	BOP1NT		BOP1NT (NUC169) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in BOP1-like WD40 proteins [1].	25.00	25.00	25.30	25.40	21.80	24.50	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.59	0.70	-4.65	38	353	2009-01-15 18:05:59	2005-02-22 15:44:34	7	9	289	0	249	359	9	244.50	45	35.02	CHANGED	Y--hsHIGYDlsGKKIhKst.ppstLDphLcsh-.cPcs..........W...RslhDthsscslpLoc--Lcll+Rlppuchsspsa-sYpshl-aFs..tcttlh..PlossP-P.KR+FlPS.KtEtK+lhKlV+AIRpGcIpspc.pcc........cpphYDlWscc.......tppptpphtclsAPKhsLPGap.ESYNPPsEYL.sccEcppWpph..c.c-RchpFlPp+asuLRpVPuYpchlpERFERCLDLYLsPRs++p+lsl.DPEsLlPKLPsP+-L+PFP	...................Y--hsHIGYDlsGK+Ih+Pt....pt-tLDphL-ph-.sP.c.h..........W...pslhD.toG.pslpLoc..--lcLlc+lp.psc..hscssas...PY...psh.l-aFo..tc.tlh..Pl.os.tP-s.KRpFlPS.+h.Et+..+VhKlV+AI+tGhIhs.+.hcp.............p.phYDLWus-...........p.ts.cphhalPAPKhs.PG.at.ESYNPPsEYL.sccEcptWppt.......-sp-R..........ch.pFlPp+asuLRpVPuYpchlcE......RFERCLDLYLsPRs..R...+....+.lNl.D.P.-sLlP+LPsPc-L+PFP...............	0	96	148	210
+7978	PF08146	BP28CT		BP28CT (NUC211) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in BAP28-like nucleolar proteins [1].	20.50	20.50	20.80	23.40	20.40	18.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.80	0.71	-4.49	29	300	2009-01-15 18:05:59	2005-02-22 15:45:25	7	10	246	0	210	299	0	152.00	29	8.80	CHANGED	Kpshsspps.lhchhLpAhDhRppp.........................phstpslsclEsplhss.hlphlhKLs-ssFRPLFhcLhcWAhst...tt........pssphpRhlsFa+hhsplt-sLKSlhosYhuall-sss.plLpph....................sssssss...........................hpLhphlLpsLppsFpaDp-pF	.........................pphsppts.lhphhLpAhDhRppp................................p.shpplsclEss....l...hcs.hlshlhKLs-ssFRPLFh+Lh-WAts................................psuptsRhloFYphhsplt-pLK................ulhTsahuallcsss.plLpps...............................................s.pptpp........................................htLhphlLp..sLppsFhaDpppF............................................	0	68	114	174
+7979	PF08147	DBP10CT		DBP10CT (NUC160) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in the Dbp10p subfamily of  hypothetical RNA helicases [1]. 	20.60	20.60	22.50	22.30	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.44	0.72	-4.16	23	302	2009-01-15 18:05:59	2005-02-22 15:49:32	7	8	257	0	208	294	1	63.70	37	7.59	CHANGED	DLssD-stt...htpp+phh+WD+KKpKaVsh.....uspsspKhI+uESGt+IsA.Sa+SG+a-cWpKp+	...........DLhsD-stp......hppppphh+WD+K+KKaVst..................suppsp..K..hI+sESGthI.s....A..S...a+.o..u.p....a.ccW+pp.p...	1	67	110	172
+7980	PF08148	DSHCT		DSHCT (NUC185) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases [1].	21.90	21.90	22.70	25.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.96	0.71	-5.04	102	1286	2009-01-15 18:05:59	2005-02-22 15:57:23	7	24	846	4	689	1241	370	174.30	29	17.64	CHANGED	hsssshs.pl..+GRlAscIpu...tsELllsEhlhsu.hhscLsPpclsAllSshVa-p+pssp.........ss............plpcshpp.......ltpltpcltplppcppl...........hhp.....p..phsLhplV..apWApGtsasplh..........phT.sl.EGslVRhh+Rlt-lLcQltpA.........hhusspLppphc.pAhphl+R..slVhtsShhl	.................................h...tthl.p...cGRlsscI...po...tsE...LllsEhlhsG.hassLsP.t.plAAl.lSshVapp+ssst..............ss.........................pLtpshpp........................................lp.c.l.tpclsplppc.ppl..............t.............hhpp...chslhcll..YpWAp.Gt.sasplh....................pho..-l.EGslVRhh+Rlt-lLcQl....tpA...............................hhu..s..spLtp....phc..pA.hptl+R..slVhhs.................................................	0	256	432	601
+7981	PF08149	BING4CT		BING4CT (NUC141) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in the BING4 family of nucleolar  WD40 repeat proteins [1].	20.90	20.90	22.50	20.90	20.60	18.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.58	0.72	-4.47	31	342	2009-01-15 18:05:59	2005-02-22 15:57:57	6	6	292	0	239	342	11	78.80	53	14.46	CHANGED	PYhsH..tsusplpslpFsPaEDlLGlGHspGFoSllVPGuGEsNaDuhE..sNPaETpKQRpEpEV+sLL-KLsPEhIoL-P	..................PYhsa....t.utplpslpFCPaEDVLGlGH.spG............aoSllVP..GAGEsNFDuhE..sNPaEo.pKQRpEtEV+uLL-Kl.PEhIsLDP..................	0	86	134	202
+7982	PF08150	FerB		FerB (NUC096) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is central domain B in proteins of the Ferlin family [1].	25.00	25.00	29.50	27.30	24.80	23.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.62	0.72	-3.91	5	436	2009-01-15 18:05:59	2005-02-22 16:00:55	7	62	72	0	247	370	0	75.70	48	4.27	CHANGED	PQNSlPDIhIWMlpG-KRlAYARIPAHQVLYSpss-ptsGKsCGKlQTlFLKYPt-KssGs...+VPVKlRVpLWLGLS	...PQsSlPDVhIWMlpssK.RlAYARlPA+plLaShs.p.p..tsG+pCGKlQTlFLK..............h..P..t....ccs..G................pls.uclclhlWLGL.....................	0	47	64	150
+7983	PF08151	FerI		FerI (NUC094) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is present in proteins of the Ferlin family.  It is often located between two C2 domains [1].	28.00	28.00	28.20	29.20	27.60	27.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.55	0.72	-3.96	16	414	2009-01-15 18:05:59	2005-02-22 16:01:35	7	51	80	0	250	369	4	71.60	46	3.94	CHANGED	lDlGhlYcpPsHtFh+KWslL......oDPcDp....puGsKGYlKlolhVlGp.............GDp...sshph.tsssscp-DIEsNLLl.PsGV	...........hDlGolYspP..s.......H..pah+KWhlL.......sDP.-.D.h......ouG.s.KGYlKsslsVlGp.............GDp...s.spp....+st.ss-p-DIEuNLLl.PtGh.................	0	52	73	156
+7984	PF08152	GUCT		GUCT (NUC152) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is the C terminal domain found in the RNA helicase II / Gu  protein family [1].	21.20	21.20	21.20	21.40	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.22	0.72	-4.00	19	241	2009-01-15 18:05:59	2005-02-22 16:02:17	7	10	123	1	143	235	2	96.60	33	14.30	CHANGED	Gaop.lcpRSLLouhcGaVTlhLpss.psh.shuasaphL+p.Ls-...ptsspl+slsLhtDs..pGsVFDVPp-.s-chhst.tcs.......uhpLsssppLPs..Lpp	........Ghop.hcpRSLloucpGalThhLpss....ppht..s..hu..aua+pLpc..pLu-....shss..clpphsl.lcsp....hGs.sFDVPsptsccl.pphpcs..............phpLolsscLPcLp..............................................	0	47	77	102
+7985	PF08153	NGP1NT		NGP1NT (NUC091) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in a subfamily of hypothetical nucleolar GTP-binding proteins similar to human NGP1 [1].	21.40	21.40	21.90	24.50	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.77	0.71	-4.19	37	376	2009-01-15 18:05:59	2005-02-22 16:02:59	7	9	299	0	254	366	3	128.30	43	21.82	CHANGED	MY+ph+shRstcGcllpst.hQ..sp.ptssARIcPsR+WFGNTRVIuQcsLppFR-thupptpDPYpVllKpsKLPhSLLp-s.....t+ppcs+l.l-sEsappTFGP.KupRKRP+.L.sssslE-LuppApp.pppsY	..................................MY+p..Ks..hRspcGcll+sstaQ.......sp..sss...sARl-PsR+WFGNTRVI.uQpuLppFR-phupphpDPYpVllKpsKLPMSLLp-p.......................+pp+s+l.l-TEsFpsTFGP.KuQRKRP+.L...sssslc-LsppuppptppY.........................	1	99	146	212
+7986	PF08154	NLE		NLE (NUC135) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is located N terminal to WD40 repeats.  It is found in  the microtubule-associated protein Swiss:Q12024 [1]. 	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.88	0.72	-3.96	66	603	2009-01-15 18:05:59	2005-02-22 16:03:45	7	15	305	0	433	599	6	64.60	28	13.67	CHANGED	plhlpFhocptt...phsssshhlPsslsp.hsLspllNp..LL..............psccslPF-Fllss.p....hl+soLpcal	...............lhlpFhopps...hphss.ssltlP.s....s.lsp.tpLspllNp..LL..........................psccsl..PasFhlps.p.........lpsoLtchh......................	0	154	243	360
+7987	PF08155	NOGCT		NOGCT (NUC087) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in the NOG subfamily of nucleolar GTP-binding proteins [1].	20.10	20.10	21.20	23.40	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.37	0.72	-4.28	29	370	2009-01-15 18:05:59	2005-02-22 16:04:31	6	11	298	0	245	355	1	53.40	52	8.46	CHANGED	+++Lp+DlEpE..pGGuGVYslDL+KpYhLts-EWKaDhlPEIhsG+NlsDFlDPDI	...............+RKLERDlE.E...uhussYslDL.+KpY.....Ltss-W.KaDhIPEIh-G+NlhDalDPDI....	0	87	138	203
+7988	PF08156	NOP5NT		NOP5NT (NUC127) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in RNA-binding proteins of the  NOP5 family [1].	21.60	21.60	22.00	21.70	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.99	0.72	-3.81	69	744	2009-01-15 18:05:59	2005-02-22 16:05:18	8	14	327	0	499	728	15	65.40	36	12.64	CHANGED	halLaEo...............uuGYuLFKlttctchhss...pltcphpshpphschVcLpuFp.FcsstpAL-sssslsEG	............halLaEo...............uuGYALF+lt.ctc....hss.......plt....cp.hpshp+hschV+LtuFp.Fp..ssspALc..s..ssulsEG...........................	1	178	282	416
+7989	PF08157	NUC129		NUC129 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in a novel family of hypothetical nucleolar proteins [1].	25.00	25.00	31.10	49.00	18.90	18.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.90	0.72	-4.06	4	38	2009-01-15 18:05:59	2005-02-22 16:06:17	6	1	32	0	22	34	0	61.20	66	27.01	CHANGED	YhssRLKDpshpsSpQpAAccFIpSpLYGPsosRTTsNchLSLpNKRussKtAAsQFlspsWu	.YlAVRLKDQDLRDSRQQAAcsFIpssLYGPGTNRTT.....VNKFLSLsNKRhPVKKAAVQFLNsuWG.	0	1	3	9
+7990	PF08158	NUC130_3NT		NUC130/3NT domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This N terminal domain is found in a novel nucleolar protein family [1].	25.10	25.10	25.60	25.80	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.34	0.72	-3.68	29	303	2009-01-15 18:05:59	2005-02-22 16:10:13	7	7	261	0	217	296	4	51.70	41	7.26	CHANGED	FlupVusCYPc..psssFPppLt-LLppa+s....sLss-LRtpllpuLlLLRNKs.lI	......FlAp.VupCYPc......phssFPpcLt-LLppp+s...............sLcP-LR.plspuLlLLRNKslI........	0	69	113	171
+7991	PF08159	NUC153		NUC153 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This small domain is found in a a novel nucleolar family [1]. 	19.60	19.60	21.20	20.30	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.63	0.72	-7.10	0.72	-4.36	39	580	2009-01-15 18:05:59	2005-02-22 16:11:10	7	11	285	0	419	565	4	29.70	40	4.31	CHANGED	DsRFtplFEsc-FulD.os.-F+thss.spp	.DsRFp.slF-s.p-FslD.ss.cF+thpsht......	1	134	226	346
+7993	PF08161	NUC173		NUC173 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is the central domain of of novel family of hypothetical  nucleolar proteins [1].	20.20	20.20	20.30	20.40	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.21	0.71	-4.96	32	340	2009-01-15 18:05:59	2005-02-22 16:12:26	7	5	272	0	238	341	3	186.10	30	15.59	CHANGED	lschh-shL.ol+apsuhtplLplluuhF-phthp.usPhhhpsLpsluchRsspp..FshppEh-pslGuAlpuMGPEsVLshLPLNLst..ssst....pssRuWLLPlLRDplpsupLuaFpsphlPLupthpp+htc...ttsccslpsKlapTllpQlWolLPuFCshPhDLtpuF.cthAphLuslLhpps-LRssICpAL+tLl	.........................................................................................................................hphhpphL...oh+apt.shtplhpllsshFptht......h........p........u.........t..s...........hhh.phlpslschRtstp.................hshppph-p....slGuAlpuMGP-sVL..p.....hlP.Ls......ls.......tpsh........................p.sRuW....LLPlLR..-..t...l..p................s..s.....p....LuaFpsth.....lPLup......t...htp.+shc..........ht..p.s.tp....sh.psKl...a...c..o...lhtQlWslLPuFCp.h.Ph.Dlt.p.uF..p...shAchL....ush...L.c..p...s...........-LR..sslCpALppLl........................................	0	77	130	200
+7995	PF08163	NUC194		NUC194 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is domain B in the catalytic subunit of DNA-dependent protein kinases.	19.30	19.30	21.30	22.50	18.90	18.00	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.30	0.70	-5.61	8	121	2009-09-11 05:38:58	2005-02-22 16:13:54	7	15	83	0	75	118	2	341.00	37	10.01	CHANGED	sslRpuhlDRsLlTLLpHCsh-ulhpFFophIsslh-slpu+asK..ssshsa-oQllcKhusY+hlElhYuRLsK--lpScpspINpAaasSsss......cGNELTKsLhKtsasAhoEsM.sGEopLlEhR..RpYHCAAYNshlAlISCohoEhKFYpuFLFsEpsEKNpalaENLIDhcRsY...sFslElEsPhERKcKhluIR+EuR......-uupstpcpPpYLSSp.SYlsDSSLSEEhSQFDFSTGVQs..hsauop-.....ttssptutp+pEpusp........hpLEhDELNpHECMAslsuLIc.HMp+spITPps.....-cGshPt....-LPsWMKFLHsKLuNsuspLNIRLFlAKlIlNscpVF+PYA+hWluPLMQLlV....pssNsucGlHYhVVDllsTlLSWsulupPp....Gss+-El	...................................................h+.shhcRsLlsLh.pCs.sslppFF....s.p.lsphhsh.lpschs+.........sptth-...s...plhcKhu...hachl-lhYsRLsK--lpuppupINpsa.ps.s.s.hs.......cGsELT+sLlKhs.acA.............h.......o...E..sh..s......G-.spL....l..Et+..............R.YHCAAYNC..hlulIssshs-.....K....FYpuFLFs.Ecs-Ks.hlaENlID.hc+pY...sFsl.El...Esshc.c...+..c+h...l..tI.Rccsp................ct.tt..s.....p...p..tspYhu...S....s.....a.hs-SSLSEEh.o...p.F..D..Fosu.Vps..hshssps...........stssphphpcpc.tp.............................hcLEhDE.LNpHECMsshssLlp.HMp+.s......l.Pt.........pp..sshst.................................plPsWMchL+sKLss.stsslNIRLFluKlllN......sp.-VF+PYA+aWLsPLlQl.......ll..........sts..sGucGl..HYhVl-llsslL.SWsslusP.....s.................................	1	36	43	59
+7996	PF08164	TRAUB		Apoptosis-antagonizing transcription factor, C-terminal	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This C terminal domain is found in traube proteins [1]. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.	20.30	20.30	20.50	20.50	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.85	0.72	-3.88	30	299	2009-01-15 18:05:59	2005-02-22 16:22:17	7	6	263	0	214	301	3	82.10	41	16.59	CHANGED	YcsLL+-Ll-p+sssuss..............t...sshhhphspppsKhKKsVDTKASKGRKlRYpVp-KLtNFM.AP.psphsWs.......-cth-ElFuoLh	.....................YppLL+-LlEp+susssss...............t...spphhthtphcsK..h+K.p.VDpK.ASKGRKlRYpVppKLhNFM.AP...spsshs.............-cshsEhFtoLh...................	0	71	115	175
+7997	PF08165	FerA		FerA (NUC095) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This is central domain A in proteins of the Ferlin family [1].	22.20	22.20	22.20	23.10	20.70	22.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.86	0.72	-4.30	12	211	2009-01-15 18:05:59	2005-02-22 16:23:34	6	33	52	0	98	201	0	64.60	36	3.52	CHANGED	hulpApssssplsplhlcll-plIpDspp..LPplcsp.sssssLDhplpcLRpppLppIpEtAh+h+	...............ulpuphstpplsplhhpLlD-lIpD...spp..sLP..slctp.sssThLDpplh+LRsppLppIpEA.Ahph+...	0	18	25	51
+7998	PF08166	NUC202		NUC202 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found in a novel family of nucleolar proteins [1].	25.00	25.00	34.20	26.80	24.00	22.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.14	0.72	-4.11	4	96	2009-01-15 18:05:59	2005-02-23 09:50:55	7	4	31	0	52	81	0	70.40	48	12.27	CHANGED	PYoSsRC+..lYplL.shlhs..........C.......GtopssLQsutasoEALls..tLlpshsPP...............h.phG	......PYoosRs+..lYsl...L.hhl.s...........C.......GtptssLpsuu.suEALlT..tLhpshsPP......................s..........	0	11	14	22
+7999	PF08167	RIX1	NUC201;	rRNA processing/ribosome biogenesis	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	Rix1 is a nucleoplasmic particle involved in rRNA processing/ribosome assembly [1,2]. It associates with two other proteins, Ipi1 and Ipi3, to form the RIX1 complex that allows Rea1 - the AAA ATPase - to associate with the 60S ribosomal subunit. More than 170 assembly factors are involved in the construction and maturation of yeast ribosomes, and after these factors have completed their function they need to be released from the pre-ribosomes. Rea1 induces the release of the assembly protein complex in a mechanical fashion [3]. This family is usually associated with NUC202, Pfam:PF08166.	25.80	25.40	25.80	25.40	25.70	24.50	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.76	0.71	-4.57	37	221	2009-01-15 18:05:59	2005-02-23 09:51:27	7	9	181	0	158	213	0	166.40	23	20.46	CHANGED	h.hllssLppsptlhss...................spstlpclhs+.ltsLLpopsspsRWsGlsLl+shlpts.hplL.ppussalpsLlslLpp................spshtshphsl.slsplhphhpshPoL..oRElhTPpLssh.........Isshlslhp....................phllssLpcLlh.pHPTsFRPFsspl+shLhplls	...................................................h....ht.ltppt.lhss..........................ttstlptLhsp...lssLL..put...psR....a.tGlsLlpshlpts....h.-hh.pps.ssWlpu.lhplLpp.........................scs..s.shc..hslhsLsclh......p.hstphPsL..sR-l.s.ssp.Lssh.........lsshLs..Lhp.....................th.p...ssLpshppllh.haPssh+shtsplpshlhshl.h............................	0	41	81	124
+8000	PF08168	NUC205		NUC205 domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found in a novel family of nucleolar proteins [1].	25.00	25.00	28.00	27.00	22.60	21.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.07	0.72	-4.56	4	52	2009-01-15 18:05:59	2005-02-23 09:51:41	6	1	37	0	25	55	0	44.00	54	6.46	CHANGED	EpsVhpSFossVspKFISLhSLSSDG.ClYETLIPIpsoDsEcNQ	...EpSlhcSFTASVDpKFISLMSLSSDG.CIYETLIPIpPsDPEKNQ..	0	2	2	7
+8001	PF08169	RBB1NT		RBB1NT (NUC162) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found N terminal to the ARID/BRIGHT domain in   DNA-binding proteins of the Retinoblastoma-binding protein 1 family [1].	25.00	25.00	25.80	26.80	21.30	24.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.31	0.72	-4.05	7	171	2012-10-02 16:56:36	2005-02-23 09:51:57	6	4	73	1	86	164	0	96.30	50	8.53	CHANGED	RRLNDELLGKVVsV....psptccssWasALVVSPSCsDDloVKKDQCLVRSFtDSKFaoVARKDl+Elss.slsKu-hsh+pGhctAhhFhps+tlPcs	........R+.pDEL.LGKVVsV......st..cpc...KspWaPAL..VVu.....P.....oC..sD.-....l..s.VK...KDphLVRSFpD.uK.FaS.......VsRKDl+E.lstp......shPKs-.h.s.hK.uhppAhpFh+o+slPsp..............................	0	17	22	49
+8002	PF08170	POPLD		POPLD (NUC188) domain	Staub E, Bateman A, Mistry J	anon	Staub E	Domain	This domain is found in POP1-like nucleolar proteins [1].	25.20	25.20	26.30	25.30	24.60	25.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.02	0.72	-4.14	31	292	2009-01-15 18:05:59	2005-02-23 09:52:11	7	8	256	0	218	296	1	95.00	31	11.29	CHANGED	sWslllPata.shshWhtL...............sph......ss+hsGL+phcQlshEpstshFPtDaPt.opuGhthpph.ppcptcpcap++P.u....KRls.applshht.............sFssDW	.............................sWslllPhta.shshWhs.l...............hhh.......ssRhuG......L+Etpp.....luhEpt.t.....shFPt.D..aPs.....ot..AGh...............thttp.ptpphppcap..R+P.u....KRss.atpls.hhs.............satssW................................	0	70	114	178
+8003	PF08171	Mad3_BUB1_II	Mad3_like; 	Mad3/BUB1 homology region 2	Mistry J, Wood V	anon	Pfam-B_113144 (release 16.0)	Domain	This domain is found in checkpoint proteins which are involved in cell division.  This region has been shown to be necessary and sufficient for the binding of MAD3 to BUB3 in Saccharomyces cerevisiae. This domain is present in BUB1 which also binds BUB3 [1].	20.90	20.90	20.90	21.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.38	0.72	-4.08	8	63	2009-01-15 18:05:59	2005-02-23 09:52:36	6	2	48	7	39	66	0	73.40	37	8.76	CHANGED	KIslF+Dsh..............ucssPVYKLIcsPG+KsEKIssNFcLLYP-scc......EaClEEILA...luRsl......Y+cppsphK...c-	............KhsIFpDph...........................spssPVYplIpssG+KPE+IssNhcLIYs-sc-......EashEElLA...lSRsl.......Y+p.ppth...pp......................	1	7	21	35
+8004	PF08172	CASP_C		CASP C terminal	Mistry J, Wood V	anon	Pfam-B_7701 (release 16.0)	Family	This domain is the C-terminal region of the CASP family of proteins.  It is a Golgi membrane protein which is thought to have a role in vesicle transport [1].	28.00	28.00	34.30	31.30	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.62	0.70	-5.35	29	261	2009-01-15 18:05:59	2005-02-23 09:53:29	7	5	207	0	179	266	3	229.80	33	35.98	CHANGED	hppLppplspsstclpctcpLst+LEsDLtplptt.shstt.ssstuhhshhspphst..........t..ph.uPsssh.s......................ssssSlLPIlosQRDRFRpRNsELEc-L.+ctppplspLcpElssL+tDNhcLYEKhRYlpSYs....................ss.sssthstss....................s.t.............................................pYpppYEppLsPhsuF+t+EppRh.hp+lus....hERhhhShsRhlLus+toRhlFhhYslsLHhlVhhhhhh.huhss.hph	..........................................................................h.tpLptclsphpsphpcpppL.t+LEpDL.plpt...h.tp......spshuh...shh.pphsps....................h..sph.uPsuuh.hst...............................................................usssulLsllouQRDRFRpRNpELEp.........El.pptppplptL..ppElssLptDNlpLYEKhRalpoYst...............................sssssth...........................s.t....................................................................................+YpptY..Epp...lsPFuuFpt+EppRt.hpplSs........................h-+hhhShsRhlLuN+huRslhhhYslhLHhLVFhhLYh.huhsp....h...............................	0	63	104	152
+8005	PF08173	YbgT_YccB		Membrane bound YbgT-like protein	Rossi R	anon	Short protein clustering	Family	This family contains a set of membrane proteins, typically 33 amino acids long.  The family has no known function, but the protein is found  in the operon CydAB in E. coli. Members have a consensus motif (MWYFXW)  which is rich in aromatic residues.  The protein forms a single membrane-spanning helix.  This family seems to be restricted to Proteobacteria [1].	26.10	26.10	26.70	26.60	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.21	0.72	-4.12	36	1086	2009-01-15 18:05:59	2005-02-23 11:52:44	6	1	889	0	151	341	16	28.00	61	71.26	CHANGED	MWYFuWILGlsLAsuhullNAhWhEhpp	MWYFAWILGsLLACuFGlIsAlhLEphp..	0	23	66	108
+8006	PF08174	Anillin	DUF1709;	Cell division protein anillin	Mistry J, Wood V	anon	Pfam-B_55293 (release 16.0)	Domain	Anillin is a protein involved in septin organisation during cell division.\	    It is an actin binding protein that is localised to the cleavage furrow, and it maintains the localisation of active myosin, which ensures the spatial control of concerted contraction during cytokinesis [3].	21.50	21.50	21.80	21.90	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.89	0.71	-4.13	70	383	2009-01-15 18:05:59	2005-02-23 14:59:18	6	8	201	0	244	378	0	146.60	19	15.15	CHANGED	sspstlshs....shplshttct.......hpchF..sstc..............pppthhshh......................chs.......sshcsph..h...sp-.Gshupshlshss..hph................pshupsaplclplasp....hpppsssspppphttt............................pt....................................ssapl..Gplplplhhlsc	......................................................puplslS..sl+lPLhhc.............thF...ps.p.p.................................pphhhhhhh...................................+hu...........c.hcsph.hhs..sps....hshstlsFps.hhh......................ps.sus-F.plclElYut.h...pcptshsss.s.+.+http.........................tt.hs++.......................................................tstapl..uphpLsLt.l..............................................................	0	55	97	181
+8007	PF08175	SspO		Small acid-soluble spore protein O family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins  (SASP) O type (sspO). SspO (originally cotK) are unique to  the spores of Bacillus subtilis and are expressed only in the  forespore compartment of sporulating cells of this organism.  The sspO is the first gene in a likely operon with sspP and  transcription of this gene is primarily by RNA polymerase with  the forespore-specific sigma factor, sigma-G. Mutation deleting sspO causes the loss of the SspO from the forespore but had no  discernible effect on sporulation, spore properties or spore  germination [1].	20.60	20.60	21.70	21.10	18.20	17.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.60	0.72	-3.64	5	137	2009-01-15 18:05:59	2005-02-23 15:09:59	7	2	133	0	23	61	0	47.80	76	63.65	CHANGED	sKRKANHVhPGMNAAKSQGNGAG....YpEE.uQcPLTpAQRQNNKKRKKNQ	....................G.KRKANHsIsGMNAASAQGQGAG....YNEEFANEsLTsAERQNNKKRKKNQ..	0	3	14	17
+8008	PF08176	SspK		Small acid-soluble spore protein K family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins (SASP) belonging to the K type (sspK). The sspK are unique to the spores of Bacillus subtilis and are expressed only in the forespore compartment of sporulating cells of this organism.  The sspK gene is monocistronic and transcription is primarily by the RNA polymerase with the forespore-specific sigma factor, sigma-G. Mutation deleting sspK results in loss of SspK from the spore but had no discernible effect on sporulation, spore properties or spore germination [1].	25.00	25.00	28.10	27.20	17.50	15.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.32	0.72	-3.96	7	127	2009-01-15 18:05:59	2005-02-23 15:10:38	7	1	127	0	20	41	0	47.40	72	89.68	CHANGED	MRNKA+GFP...NppKF-G.EPcA+scaASKRssGohNT+PQERMRASs	MG+QAEFWSESKNNSKIDG.QPKAKSRFASKRPNGTINTHPQERMRAAN..	0	4	12	14
+8009	PF08177	SspN		Small acid-soluble spore protein N family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore protein  (SASP) N type (sspN). SspN is a 48 residues protein that is  expressed only in the forespore compartment of sporulating  Bacillus subtilis. The sspN gene is recognised equally by both  sigma-G and sigma-F. The role of SspN is still not well-defined [1].	25.00	25.00	43.90	62.50	19.40	16.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.38	0.72	-4.23	8	129	2009-01-15 18:05:59	2005-02-23 15:17:28	6	1	129	0	18	37	0	44.90	71	98.57	CHANGED	MG.N.KcspsQFsPsHLGTKPhcacuNKGKKMpDKSGcpP.VhQTKG	.......MG.NPKKNSKDFAPNHIGTQSKKAGGNKGKQMQDQTGKQPIV..DNG	0	2	10	12
+8010	PF08178	GnsAB		GnsA/GnsB family	Lee SC	anon	Short protein clustering	Family	This family consists of the GnsA/GnsB family. GnsA and GnsB  are multicopy suppressors of the secG null mutation. These  proteins participate in the synthesis of phospholipids,  suggesting the functional relationship between SecG and  membrane phospholipids. Overexpression of gnsA and gnsB causes  a remarkable increase in the unsaturated fatty acid content.  However, the gnsA-gnsB double null mutant exhibits no effect.  Both proteins are predicted to possess a helix-turn-helix  structure [1].	25.00	25.00	32.60	30.30	21.80	19.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.62	0.72	-4.31	4	459	2009-01-15 18:05:59	2005-02-23 15:20:45	6	1	376	0	7	49	0	53.40	75	71.87	CHANGED	MN.EcLK+pAEp-IusaIoKKlsELpKpTGKEVoEIcFssREpMsG...LESYcVKI	...MNIEELK+pAEsEIA-aIupKIAELpKpTGKEVSEIcFTAR.EKMTG.....LESYDVKI..........	0	3	3	5
+8011	PF08179	SspP		Small acid-soluble spore protein P family	Lee SC	anon	Short protein clustering	Family	This family consists of the small acid-soluble spore proteins (SASP) P type (sspP). sspP is expressed only in the forespore compartment of the sporulating cell. sspP is also expressed under sigma-G control from the same promoter as sspO. Mutations deleting sspP causes no discernible effect on sporulation, spore properties or spore germination [1].	25.00	25.00	25.10	31.50	21.40	24.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.13	0.72	-3.76	8	120	2009-01-15 18:05:59	2005-02-23 15:21:37	7	1	120	0	20	59	0	41.10	67	92.60	CHANGED	M.sKNsuKchRpNspKGcssGQP..EPLSGSKKVKNRNHoRQKHssH	....................................+pNppptcp.p.GQP..EPLSGSHKVKNRNHSRQK+pu....	0	3	11	13
+8012	PF08180	BAGE		B melanoma antigen family	Lee SC	anon	Short protein clustering	Family	This family consists of the B melanoma antigen (BAGE) peptides.  The BAGE gene encodes a human tumour antigen that is recognised  by a cytolytic T lymphocyte. BAGE genes are expressed in melanomas,  bladder and lung carcinomas and in a few tumours of other histological  types [1].	20.60	20.60	22.50	21.70	20.50	18.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-6.93	0.72	-4.19	5	119	2009-01-15 18:05:59	2005-02-23 15:22:01	6	2	112	0	16	78	0	28.70	74	4.85	CHANGED	LIAASlWLAA.SAQALEAKLpK-DLPlLA	.LIAASLWLAA.SAQALE.....A.....KL+.EDLPlLs..	0	6	8	13
+8013	PF08181	DegQ		DegQ (SacQ) family	Lee SC	anon	Short protein clustering	Family	This family consists of the DegQ (formerly sacQ) regulatory peptides. The DegQ family of peptides control the rates of synthesis of a class of both secreted and intracellular degradative enzymes in Bacillus subtilis. DegQ is 46 amino acids long and activates the synthesis of degradative enzymes.  The expression of this peptide was shown to be subjected both to catabolite repression and DegS-DegU-mediated control. Thus allowing an increase in the rate of synthesis of degQ under conditions of nitrogen starvation [1].	20.90	20.90	22.00	94.60	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.27	0.72	-4.24	3	28	2009-01-15 18:05:59	2005-02-23 15:22:52	6	1	26	0	5	9	0	46.00	86	99.77	CHANGED	MEK.cIEELKQLLWRLENEIRETTDSLRNINKSIDQYDKYoY.lKIS	MEK.KLEEVKQLLFRLE.DI+ETTDSLRNINKSIDQLDKYsYAMKIS	1	1	2	3
+8014	PF08182	Pedibin		Pedibin/Hym-346 family	Lee SC	anon	Short protein clustering	Family	This family consists of the pedibin and Hym-346 signaling peptides.  These two peptides have been isolated from Hydra vulgaris and Hydra magnipapillata. Experiments have indicated that both cause a reduction in the positional value gradient, the principle patterning process governing the maintenance of form in the adult hydra. The peptides cause an increase in the rate of foot regeneration following bisection of the body column. Thus both play important signaling roles in patterning processes in cnidaria and maybe in more complex metazoans [1].	27.00	27.00	39.50	42.00	24.20	18.20	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.37	0.72	-4.45	4	5	2009-09-11 09:46:32	2005-02-23 15:23:37	6	2	3	0	3	5	0	32.20	49	8.64	CHANGED	pLptEIslLQ.hhA-GEDVscpLEpKEKtLpNhcp	pLptEIslLQ.hhA-GEDVs+ELEpKEKALuNacc	0	3	3	3
+8015	PF08183	SpoV		Stage V sporulation protein family	Lee SC	anon	Short protein clustering	Family	This family consists of the stage V sporulation (SpoV) proteins  of Bacillus subtilis which includes SpoVM. SpoVM is an small,  26 residue-long protein that is produced in the mother cell chamber  of the sporangium during the process of sporulation in B. subtilis.  SpoVM forms an amphipathic alpha-helix and is recruited to the polar  septum shortly after the sporangium undergoes asymmetric division.  The function of SpoVM depends on proper subcellular localisation [1].	20.60	20.60	21.40	22.90	19.80	19.50	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-6.70	0.72	-4.18	3	45	2009-01-15 18:05:59	2005-02-23 15:24:02	6	1	44	0	19	38	0	25.90	67	15.99	CHANGED	MKFYTIKLP+FVGGlV+slLGSFKKD	..MKFYTIKLPKFLGGlVRAhLsSF+K.t	0	6	12	15
+8016	PF08184	Cuticle_2		Cuticle protein 7 isoform family	Lee SC	anon	Short protein clustering	Family	This family consists of cuticle protein 7 isoforms that are  isolated from the carapace cuticle of a juvenile horseshoe crab, Limulus polyphemus. There are 3 isoforms of cuticle  protein 7. The 3 isoforms are N-terminally blocked but could  be deblocked by treatment with pyroglutaminase, showing that  the N-terminal residue is a pyroglutamine residue [1]. 	25.00	25.00	139.70	139.60	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-4.17	3	3	2009-01-15 18:05:59	2005-02-23 15:24:28	6	1	1	0	0	3	0	59.00	95	100.00	CHANGED	QAVRYANGYTYDIETGQVSSPYTGRVYETKGKAPFYGFGFEHPYHYYPGYYHGYPHAFY	QAVRYANGYTYDIETGQVSSPYTGRVYETKGKAPFYGFGFEHPYHYYPGYYHGYPHAFY	0	0	0	0
+8018	PF08186	Wound_ind		Wound-inducible basic protein family	Lee SC	anon	Short protein clustering	Family	This family consists of the wound-inducible basic proteins  from plants. The metabolic activities of plants are  dramatically altered upon mechanical injury or pathogen  attack. A large number of proteins accumulates at wound or  infection sites, such as the wound-inducible basic proteins.  These proteins are small, 47 amino acids in length, has no  signal peptides and are hydrophilic and basic [1].	25.00	25.00	27.00	25.90	23.20	20.20	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.25	0.72	-4.05	4	21	2009-01-15 18:05:59	2005-02-23 15:25:19	6	5	16	\N	13	22	0	43.50	66	43.31	CHANGED	MIY-ssSuLFRSFL.ppupssDKRppEsp+.pt.t.KASsNKP...VMsE	..........MIYDVNSPLFRSFLSQKG.u.uuDKRKhEEpKPK-Q+.KAsENKP...VMsE.......	0	3	10	12
+8019	PF08187	Tetradecapep		Myoactive tetradecapeptides family	Lee SC	anon	Short protein clustering	Family	This family consists of myoactive tetradecapeptides that are  isolated from the gut of earthworms, Eisenia foetida and  Pheretima vitata. These peptides were termed ETP and PTP  respectively. Both peptides showed a potent excitatory action  on spontaneous contractions of the anterior gut. These peptides  show similarity to Molluscan tetradecapeptides and arthropodan  tridecapeptides [1].	25.00	25.00	37.80	37.80	17.60	15.60	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.49	0.74	-6.07	0.74	-3.72	2	2	2009-09-11 09:59:55	2005-02-23 15:25:42	6	1	2	0	0	2	0	14.00	86	100.00	CHANGED	GF+DGuADRISHGF	GF+DGuADRISHGF	0	0	0	0
+8020	PF08188	Protamine_3		Spermatozal protamine family	Lee SC	anon	Short protein clustering	Family	This family consists of the spermatozal protamines.  Spermatozal protamines play an important role in remodelling of the sperm chromatin during mammalian spermiogenesis. Nuclear elongation and chromatin condensation are concomitant with modifications in the basic protein complement associated with DNA.  Somatic histones are initially replaced by testis -specific histone variants, then by transitional proteins, and ultimately by protamines [1].	25.00	25.00	112.10	112.00	22.80	17.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.72	0.72	-3.98	2	2	2009-01-15 18:05:59	2005-02-23 15:26:42	6	1	1	0	0	2	0	48.00	98	100.00	CHANGED	ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKtHGFLKQPPRFRP	ARRRHSMKKKRKSVRRRKTRKNQRKRKNSLGRSFKtHGFLKQPPRFRP	0	0	0	0
+8021	PF08189	Meleagrin		Meleagrin/Cygnin family	Lee SC	anon	Short protein clustering	Family	This family consists of meleagrin and cygnin basic peptides that are isolated from turkey and black swan respectively. Both peptides are low in molecular weight and contains three disulphide bonds with high concentrations of aromatic residues. These peptides show similarity to transferrins and probably play some vital role in avian eggs but the exact function is still unknown [1].	25.00	25.00	30.30	30.00	17.90	15.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.34	0.72	-4.48	2	9	2009-01-15 18:05:59	2005-02-23 15:27:09	6	1	4	0	3	11	0	38.90	67	77.43	CHANGED	QVhKYCPKlGYCSSKCSKA-VWuhSsDCKhaCClPss.K	.......VLKYCPKIGYCSspCSKsplWAhSpsC.KhYCCLPAuWK	0	0	0	1
+8022	PF08190	PIH1	Nop17p; 	pre-RNA processing PIH1/Nop17	Mistry J, Wood V	anon	Pfam-B_10462 (release 16.0)	Family	This domain is involved in pre-rRNA processing [1].  It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae [1]. The C-terminal region of this family has similarity to the CS domain Pfam:PF04969.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.88	0.70	-4.99	26	646	2012-10-02 21:54:05	2005-02-23 15:49:18	7	21	191	0	432	665	8	212.10	14	58.79	CHANGED	LpD.ppc......cthcp.lpphpppps..p.hhhlpPpPGaClKTphsss.t...KsFINlCpssclstP...pppthht...stt.shpaplPhSlups+tptDpsspsCsVaDVlhNPsslppspcsptF+phlhshAhculcpca...plpLs.csh+hh.phKaKG.shpspplRtpt.tp..tt.t................................ssphttpptstplhpph................ptt...s.t..hpphssst......stpPpY..............phphhpcs......psshPcplllclcLPtlpSsppssLcluccclhl.stp................................tYhLs...l.LPYslcc-pspApFs+pp+tLplphPV	.........................................................................................................................................................................................................................................................................................hhl.Nh......h...................................................................hP....h..........p....................................................h.hshhhp..h.h.................................................h.....h.ht..ht.............t.....h...........h...........................................................................................................................................................................................................................................................................................................................................................................................s...h.hp...h.h...s........h....t...t.h.lplt.........h.h........................................h....h.hs...l.......t.......s.h....................................................................................................................................................................................	1	180	235	336
+8023	PF08191	LRR_adjacent		LRR adjacent	Mistry J, Schubert WD	anon	Pfam-B_1177 (release 16.0)	Family	These are small, all beta strand domains, structurally described for the protein Internalin (InlA) and related proteins InlB, InlE, InlH from the pathogenic bacterium Listeria monocytogenes. Their function appears to be mainly structural: They are fused to the C-terminal end of leucine-rich repeats (LRR), significantly stabilising the LRR, and forming a common rigid entity with the LRR.  They are themselves not involved in protein-protein-interactions but help to present the adjacent LRR-domain for this purpose.  These domains belong to the family of Ig-like domains in that they consist of two sandwiched beta sheets that follow the classical connectivity of Ig-domains. The beta strands in one of the sheets is, however, much smaller than in most standard Ig-like domains, making it somewhat of an outlier [1] [2] [3].	21.80	5.70	21.80	5.70	21.00	5.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.77	0.72	-4.25	29	1133	2009-01-15 18:05:59	2005-02-23 17:17:53	6	181	124	32	13	1027	3	56.90	48	9.22	CHANGED	GsllsPssIScNGsYsssslsW.s.LPs..a..hsEVSYsFsp.lplG.pspspFoGpVhQPLpp	.............GsLlsPtoISDsGoY......s..p..Ps..lsW.s...LPs..a....hNEVSYsFsQsVslG.ps.....pssFSGTVTQPL+.........................	1	11	11	11
+8024	PF08192	Peptidase_S64		Peptidase family S64	Mistry J, Rawlings N	anon	Rawlings N	Family	This family of fungal proteins is involved in the processing of membrane bound transcription factor Stp1 [1].  The processing causes the signalling domain of Stp1 to be passed to the nucleus where several permease genes are induced.  The permeases are important for uptake of amino acids, and processing of tp1 only occurs in an amino acid-rich environment.  This family is predicted to be distantly related to the trypsin family (MEROPS:S1) and to have a typical trypsin-like catalytic triad [1].	19.80	19.80	19.80	19.80	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	695	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.26	0.70	-6.19	9	71	2009-01-15 18:05:59	2005-02-24 11:40:50	6	2	57	0	45	71	3	457.00	26	72.60	CHANGED	M.hpphFuhs+tpc.t-tpsp...t-tppsps.tsss...........pso.hthcsh.ps..hospsssuspuSuh...........ascuphshssulSsh..p.ssoh.pp.....sutpsssuhhu.tsst+shpsppsSh.s..ssh.ttppssotssucspssssSp.hp.hshsEppppp..ppt..pltcpLppLtpcLshlMsplppslhNlSpAVIssI-hFKcF..............................h.oh.............psphsaplos.ssuslR+IhKIhLHFhDNLLss-sa.p.+hlLl+pa.cFhppLN.psc.......tstslsp.+saAIG..psssLPscDpltpIh-cIspss.S.lp-QsGuFIAPlLRGlopchsILslhFGhPsPpppHachlpsLasLas.DlHhhshKs.IchAusss.sss..hst...................................pph.....h.pFp.PaRlPsDs.pPPhShSlSoEsos+hSGTlGGYlYPpIs.ppps+LpuYAsupFAITCuHVsLspsp....sYPpVusPSsVL.shYKpuLtcphp+as...........-spltasuhhpplpcl...hphp....................scp+FGQllWGERolIs.......................p+LSDhAIIKVNpphcC.pNaLGDDlt.s..DPuLhFcNLYVRKh..lp+hpP..........................GhpVFKhGuTTKYT+GslNGlKLVYWhDGcIpSSEFlVsS..ssshFAuGGDSGuWILTKL-D......phGLGVlGMLHSYDGEhKQFGLFTPhs-IL-RLcpVTsIcWsl	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...................................................................hGplh....h..up+.h.p.......................tph...DhAllchs...tph.s.tNhl..Gssl....t..sPsh..hhpNh.Vpph.....l.p..hts............................Gh.pVFKhGsoTsaTsGp...lN.u...h...+...L.l...Y.Ws.......D..Gp......l..p..o....o..EF...lVsS.........sssh...............FAsuGDSGualLoKhps.............................t.uLsllGMlauhDtc.tpasl..hoPht.I.pclp.hT..................................................	0	9	24	39
+8025	PF08193	INO80_Ies4	DUF1711; 	INO80 complex subunit Ies4	Wood V, Mistry J	anon	manual	Family	The INO80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodelling complex.  This family of proteins corresponds to the fungal Ies4 subunit of INO80.	20.10	20.10	24.40	23.90	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.76	0.70	-4.41	11	94	2009-01-15 18:05:59	2005-03-04 14:12:13	6	4	91	0	75	89	3	211.90	32	78.21	CHANGED	Muuuot.ssssssRpppuus.s...........+tlVsLKLoschLpphh.........................uss.lKccpP.....S.SPuuSsst.s..sSusDNASDus.STP..ssssuuscsPpppuhPuP......KsG...sKRussts..u-ops+sRGKPGPKKKsRL........DDGT.-.......ssphsuuHRLGPKANtG............AINAGLRALDRSGpPCR+WERKslpLKSFTGl.WpLPsWRuP.s.psEpssEspp.s.pTGDSsSKsNp...ssSul.SEKSNoG	...................................................s..t.p.s.....................phhlsLplssthLpth..................................t.....s.ct.pps.....................p.oPss...sss..............sss-ssS-...us....sTP.........ss.ssss.t.tts.hssP...........KtG......sKRuhs.t..s......ts..s..........s........hs+sRGKPGP.K.KK..RL........-DGshs..........................sts.ss.ss.p+LGPKANtG............AINAGLRALDRSGKPCRKWp+pshpLKSFTGlhWplP.sWpu......P..cs.ps...ppsspppt.................sspussptp..........pttt...up................................................	0	16	38	62
+8026	PF08194	DIM		DIM protein	Rossi R	anon	Short protein clustering	Family	Drosophila immune-induced molecules (DIMs) are short proteins induced during the immune response of Drosophila. This family includes DIMs 1 to 4 that have masses below 5 kDa [1].	20.80	20.80	20.80	20.80	20.30	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.75	0.72	-4.00	7	97	2009-09-10 23:55:24	2005-03-08 14:48:02	7	1	12	0	49	82	1	35.70	50	49.37	CHANGED	MKhLol..shslhLLA.LAsAsshs..PGpVhING-C+sCN	...MKahol..shlLuLLA..LAsAssls....PGsVlINGcChsCN...	0	10	10	31
+8027	PF08195	TRI9		TRI9 protein	Rossi R	anon	Short protein clustering	Family	Putative gene of 129 bp in the Trichothecene gene cluster of Fusarium sporotrichioides and F. graminearum. Encoding a predicted protein of 43 amino acids which function is unknown [1,2].	25.00	25.00	25.10	88.00	19.50	17.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.42	0.72	-4.32	3	20	2009-01-15 18:05:59	2005-03-08 14:50:26	6	1	19	0	1	5	0	43.00	93	100.00	CHANGED	MLAAAKLIDSYEMDPDVSWLEVFAYSGVSAALCATIWVAAKAC	MLAAAKLIDSYEMDPDVSWLEVFAYSGVSAALCATIWVAAKAC	0	0	0	1
+8028	PF08196	UL2		UL2 protein	Rossi R	anon	Short protein clustering	Family	Orf UL2 of Human cytomegalovirus (HCMV) which is a short protein of unknown function [1]	25.00	25.00	119.90	119.80	18.90	16.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.01	0.72	-4.23	2	13	2009-01-15 18:05:59	2005-03-08 14:53:45	6	1	6	0	0	10	0	59.60	86	100.00	CHANGED	MttDuVuILIVED.s..hPSFGohsASHA.YuFRlLRGIFhlTlVlWslhWlKLLRDshh	MuEDSVuILIVEDDDDAYPSFGTLPASHAQYGFRLLRGIFLITLVIWTVVWLKLLRDALL	0	0	0	0
+8029	PF08197	TT_ORF2a		pORF2a truncated protein	Rossi R	anon	Short protein clustering	Family	Most isolated ORF2 of TT virus (TTV) encode a 49 amino acids protein  (pORF2a) because of an in-frame stop codon. ORF2s isolated from G1 TTV  encode 202 amino acids protein (pORF2ab) [1].  	22.00	22.00	24.10	28.30	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.35	0.72	-4.19	2	69	2009-01-15 18:05:59	2005-03-08 14:59:27	6	2	2	0	0	64	0	33.30	77	65.01	CHANGED	MAEFShPVRSttATEGh.pVPRAGAtGEFTHRSQGAIRARDWPGYGQGS	MAEFSTPVRStpATEGc.RVPRAGAtGEFT......................	0	0	0	0
+8030	PF08198	Thymopoietin		Thymopoietin protein	Rossi R	anon	Short protein clustering	Family	Short protein of 49 amino acid isolated from bovine spleen cells [1]. Thymopoietins (TMPOs) are a group of ubiquitously expressed nuclear proteins. They are suggested to play an important role in nuclear envelope organisation and cell cycle control [2].	25.00	25.00	25.30	36.90	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.09	0.72	-4.44	7	109	2009-01-15 18:05:59	2005-03-08 15:14:41	6	4	36	2	42	92	0	48.90	74	11.69	CHANGED	spFLEDPulLTK-KLKSELlApNVsLPsu-p+K-VYVQLYLKpLTspNp	...PEFLEDPSVLTK-KLKSELlANNVoLPuGEQRKDVYVQLYLQHLTu+N+...	0	6	10	23
+8031	PF08199	E2		Bacteriophage E2-like protein	Rossi R	anon	Short protein clustering	Family	Short conseved protein described in Lactococcus Bacteriophage c2  of 37 amino acids [1].	25.00	25.00	36.80	36.80	18.10	16.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-8.11	0.72	-4.36	2	7	2009-09-10 18:27:20	2005-03-08 15:17:58	6	1	7	0	0	4	0	31.60	89	94.44	CHANGED	ML.RLLY.RFGK.IKRRlLIDNFSNFCaYNFIs.Fh.	ML.RLLYSRFGKFIKRRlLIDNFSNFCaYNFIh.Fh.	0	0	0	0
+8032	PF08200	Phage_1_1		Bacteriophage 1.1 Protein 	Rossi R	anon	Short protein clustering	Family	Gene 1.1 in Bacteriophage T7 encodes a 42 amino acid protein, rich in basic amino acids suggesting its interaction with nucleic acids [1].  Many homologs are present in different T7 and T3-like bacteriophage.	19.90	19.90	20.40	20.40	19.00	15.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.52	0.72	-3.77	6	29	2009-01-15 18:05:59	2005-03-09 11:13:14	6	1	24	0	0	18	0	42.50	49	88.58	CHANGED	MR.NFEKhTKR.uNR.scp.F-hpEt.c+G+KhNKspRsRupKRs.WE	..............MR.NFEKhTKR.sNh.scc.hEhpEtps+h+KhpKspRspupKRp.Wc........	0	0	0	0
+8033	PF08201	BssC_TutF		BssC/TutF protein	Rossi R	anon	Short protein clustering	Family	BssC short protein (57 amino acids) has been described as the  gamma-subunit of benzylsuccinate synthase from Thauera aromatica  strain K172 [1].  TutF has been identified and described as highly similar to BssC in  T.aromatica strain T1 [2]. 	25.00	25.00	34.00	33.10	17.50	16.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.94	0.72	-4.48	4	18	2009-01-15 18:05:59	2005-03-09 15:12:35	6	1	14	0	6	17	1	57.30	53	97.91	CHANGED	M..TTCKsCuFaFuVPEsAsDaEsGKGDCVppKEDtKGKYWLSKPshcsossCtsF+.Kp	...MoTCK-Cp.FFslPEsADDaEsGKGDCVpE+cDpKGKYWLSKPlh..-su..s..sCpsFp.K.t........	0	3	4	6
+8034	PF08202	MIS13	Mis12_component;	Mis12-Mtw1 protein family	Mistry J, Wood V	anon	Pfam-B_127825  (release 16.0)	Family	Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.99	0.70	-5.35	9	220	2009-01-15 18:05:59	2005-03-15 09:49:21	6	6	165	0	141	229	2	265.80	21	60.35	CHANGED	h.Lpss.hh.pppp..htpptpspR+u.hppRGRRhS.lspth.....lssPHp-VstpEaY+plsss.Lucsh+h+QLLhWshp+ulpchc.......................h.tpsp.ss.htls+sIhcphlcDh+tsphslsW.s+c.t-c.s...........sDsplpp......p.........................................................PNspNlpNcpsls.lcpKlsplcpEhppWsphh.cspp.........sshch.tppp.ht....s+lppsp.-ssss......................splhsphEpplDpLptss+pLputs.hhs-hsspplp.+lshhhtp+hhpchcp..s.t.................ohcLLRsLo........upsp	......................................................................t.......tpttps.RRuSht.pu.RRhS............................h..Hppl..s-hh+pIssp..LsEscRhppLLhWshptultch..............................................................hh+slpcthlcshtscs..hsW.s+c.tpt.s.................................l.t.......................................................................PNspNlpspppltplp..p..plp....clptEcp...pWpthh.phpp................phch...t....t....p....tt....hp..psh.psth......................................................................tth.t..sp.l..s...phchh...lDpLttts+.Lpt......h.c.ssphh.........h.t...p.t.............................................th.........................................................................................................................................................	1	31	64	109
+8035	PF08203	RNA_polI_A14		Yeast RNA polymerase I subunit RPA14	Mistry J, Wood V	anon	manual	Family	This is a family of yeast proteins.  A14 is one of the final two subunits of Saccharomyces cerevisiae RNA polymerase I and is proposed to play a role in the recruitment of pol I to the promoter [1].	25.00	25.00	58.30	54.90	21.10	19.70	hmmbuild  --amino -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.74	0.72	-3.74	17	47	2009-01-15 18:05:59	2005-03-15 10:13:06	6	1	45	3	29	38	0	79.80	43	51.19	CHANGED	sPlsl+htus.ptlsp--s.phLscFIsppEph........s..sstt.s......ssthussssssusLuQLKRlQRDL+GL.............PPhhs	.TPlllHssph.pplop-Es.pFLppFIcppEsl...........sh.ssstss.....ss.....ssTuhshcoshooslSQLKRIQRDh+GL.............PPs..s..	0	4	14	26
+8036	PF08204	V-set_CD47		CD47 immunoglobulin-like domain	Mifsud W, Bateman A	anon	Pfam-B_2739 (release 7.5)	Domain	This family represents the CD47 leukocyte antigen V-set like Ig domain [1,2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.95	0.71	-4.38	12	126	2012-10-03 02:52:13	2005-03-18 11:48:33	6	10	67	8	29	205	0	121.20	39	39.37	CHANGED	hhlsshhss..spLhhsshhoVp.aTsCNsTVslsC.lssl.hpshsplaVcW+FpscsIhhhssspp.o.......................Lphchscsl..sGNYTCEshph.p.phcphIcLph.hhpWFo.pEp	.................................h..lt..hhh..s.llhssTKolE..aTsC..N-Tll.IPCh..ls.N.......t...sphY.l+WK...h.....c....s.....+.s......I...h...o....a....sts.p..ppoh.....hsp.a.o...S.A+l......ppL..cu..s.s.S.L.h.h.-.h..p.D.hl..sGsYTCEsht.sp..th.cohlcLp.+hssWFss.p.....................	0	3	5	9
+8037	PF08205	C2-set_2		CD80-like C2-set immunoglobulin domain 	Bateman A	anon	Pfam-B_280 (release 17.0)	Domain	These domains belong to the immunoglobulin superfamily.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-9.86	0.72	-4.08	33	3971	2012-10-03 02:52:13	2005-03-18 11:48:59	7	376	126	29	2150	9868	2	86.30	17	19.89	CHANGED	splpss..shlsst.....t.phlhpCs...ossGhPssploWhpsspsh..........hpsppppsspstlholpSpLphsssp.pspspslsCplpasshptpp	......................................................................phplsCp.....ut.s..u..p..P...s..s..p.l..p..W..h.....p..s..s.p.th............................................pp..p..p..t...p....s......p...s...s.....h...h...s....s..p..S...p.l.p..h.p....s.s.t...t...t..pst....p..l.sCps.pp.......t..............................................	0	644	828	1357
+8038	PF08206	OB_RNB		Ribonuclease B OB domain	Bateman A	anon	Pfam-B_484 (release 17.0)	Domain	This family includes the N-terminal OB domain found in ribonuclease B proteins in one or two copies.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.64	0.72	-4.46	48	5260	2012-10-03 20:18:03	2005-03-18 13:56:51	6	22	3124	6	885	5744	3246	58.60	30	10.43	CHANGED	Gplpua.ccGF.GFltsDs.....tppDlFlPtpphppshcGDpVlspltt.tccct+pcupll+l	.............Ghh.sp..ccG.F..GFl.h..s.....-s............ppDlF.....I.....P.....s.....s.....p.....h.....p.....t.....u.....h......c....G.DpVl..splpp....sc...+.c..s....c....t..cGcllcl....................................	0	278	554	744
+8039	PF08207	EFP_N		Elongation factor P (EF-P) KOW-like domain	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.50	0.72	-4.10	222	5745	2012-10-01 20:16:17	2005-03-18 14:02:52	7	10	4640	16	1192	3021	2037	57.00	36	30.63	CHANGED	sss-l+pGhslph.cGp.ahl.....................l-h.pasK.PGKGsAhsRsKl+NlhoG.shh-coF+u.u-pl	..............ss-h+sGhsl..ph.-.G.p...hhtV.....................l-h..pasK..PG..K.G..s..A.hsRsKl+slhoG.phlEcTF+us-ph....................	0	397	771	997
+8040	PF08208	RNA_polI_A34	RNA_polI_final; 	DNA-directed RNA polymerase I subunit RPA34.5	Mistry J, Wood V	anon	manual	Family	This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription [1].	28.10	28.10	28.10	28.10	27.30	28.00	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.40	0.71	-4.64	25	173	2009-01-15 18:05:59	2005-03-21 15:31:00	6	2	161	8	126	170	0	209.50	20	59.28	CHANGED	ptcsKplWLIpsPsslslspL.pplslsh.....sthtpup.sslptpsppYplhp-sht........tsstuptolLlssscspthhs........tshshsphapIpEssplPths.......htpshss+.shppscGL+hRahPsGhusss....................pt.stppppsppp..pptphhppscspccEppcK+pcpE.cpp......hpcKKsKKc+..........................pcp+ccKK+KK	.............p.hpscplWhIpsPsshshssl.ppltlsh......tt.tpsp...shh.stc..sp..p...Yplhpsp....................sptsphs.lLlPsppssshhh.........tshshspshplpcssplsths...............tpshss.....pssh.p.sps..L..+hRahPhGhsss....................................tt.s.sttpsppp...pptph..p.ptp....h..p.ppc..p..pc.c+pptc....ctp...................................h.tKKpKKpc.....................................................................pp...........................................................................................................................................................................................................................................................................	0	33	64	98
+8041	PF08209	Sgf11		Sgf11 (transcriptional regulation protein)	Mistry J, Wood V	anon	manual	Family	The Sgf11 family is a SAGA complex subunit in Saccharomyces cerevisiae.  The SAGA complex is a multisubunit protein complex involved in transcriptional regulation. SAGA combines proteins involved in interactions with DNA-bound activators and TATA-binding protein (TBP), as well as enzymes for histone acetylation and deubiquitylation [1].	25.00	25.00	25.20	25.20	24.10	24.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.37	0.72	-4.63	33	238	2012-10-03 11:22:52	2005-03-21 16:24:55	6	7	194	4	166	251	0	32.80	46	10.50	CHANGED	ss.hhsC.NCsRpluusRFAsHL-+ChG.hupps	........spCsNCsR.tluAuRFAsHLEKChG.hGpp......	0	54	88	134
+8042	PF08210	APOBEC_N		APOBEC-like N-terminal domain	Finn RD	anon	Manual	Domain	A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes.  The N-terminal domain of APOBEC-1 like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent deaminases domain and is essential for cytidine deamination.APOBEC-3 like members contain two copies of this domain.  RNA editing by APOBEC-1 requires homodimerisation and this  complex interacts with RNA binding proteins to from the editosome [1]  (and references therein). This family also includes the functionally  homologous activation induced deaminase (AID), which is essential for the development of antibody diversity in B lymphocytes, and the sea  lamprey PmCDA1 and PmCDA2, which are predicted to play an AID-like  role in the adaptive immune response of jawless vertebrates [2].  Divergent members of this family are present in various eukaryotes such as Nematostella, C. elegans, Micromonas and Emiliania, and  prokaryotes such as Wolbachia and Pseudomonas brassicacearum [3].	38.10	38.10	43.90	43.60	32.50	31.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.61	0.71	-4.67	22	683	2012-10-02 00:10:39	2005-03-22 09:56:53	6	6	111	12	182	716	0	172.70	33	80.64	CHANGED	hphth+ts.hsp..................................tcppohlhhhlctpt......hh+Ghhpscs.....tttHsEphhlptlhshh................pssphaplshasShSPChc..................CActluphLpph.....tslslplhsp..pLa.h.pptt.................pppGlhphhpu...Ghplchhthp...Daphshphhs...ps-...............................cthphWpstp.shthhppp.hth.p	..............................................................................................................s+pcoaLCYpVctppsst........hsh.pGhhps..p...................ttpH.AEhpFLphhpshp................sssppYcVTWahSWSPChs..................CApclscFLppp.....sploLpIFsu..RLYah..ctp...............................hpcGLRpLpps....GspltlMshp...-FpaCWcsFV...ppt.......................................csFpPWcsLppp...............h...................................................	0	17	27	55
+8043	PF08211	dCMP_cyt_deam_2		Cytidine and deoxycytidylate deaminase zinc-binding region 	Finn RD	anon	Pfam-B_8221 (release 16.0)	Family	\N	20.90	20.90	20.90	20.90	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.54	0.71	-4.12	18	900	2012-10-02 00:10:39	2005-03-22 09:57:04	6	6	846	12	148	2195	501	122.40	54	42.26	CHANGED	LppYLP-uFGPpDLtl.....sshLh-ppspshslpssDs...............LhppALcAANpSaAPYScs.SGVALhspsGclYsGtYAENAAFNPSLsPlQuALlphshs..GcsassIppAVLVE+psuplSphusupsh	..........................................................Lc-YLPDAFGPKDLpI........coLL.MD.cpD....H.G...asL..s.u..Ds............................................................LsQAAlsA.A.N.+S.HhPYS+.S.P.SGVALE....s.............+.....D..G...+....I...F.......oGuYAENAAFNPoLPPLQuALh.hLsLp.......G.h...-.a..s...D..IpR.AV.....LsE+uc.A.sL.QhssTp..s...................................	0	35	71	109
+8044	PF08212	Lipocalin_2		Lipocalin-like domain	Bateman A	anon	Pfam-B_2479 (Release 17.0)	Domain	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The structure is an eight-stranded beta barrel.	21.10	21.10	21.10	21.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.83	0.71	-4.40	19	1931	2012-10-03 08:47:39	2005-03-23 14:57:04	7	16	1379	7	485	1577	247	138.30	39	74.08	CHANGED	lD.LpRYhGpWYElARhPhhFp.+ssscspApYsLp-DG.pIpVtNcChp..hcG...phppspGpAphtssup.su+L+VpFhs.........spu-YaVlhlDs-.YphAlVGsPsRcYLWlLSRoPplscpphppllscA+pp.GYDsscLhhssp	..........................................................................hDhpR.Y.l.Gp.WYE..I........A...R......h....s...p....p..F....E.....+...G...h....p.p....l..o.As.....Yo.L...c...s.....D.G.....s.....l.pVl..N....+shs..........ct..............hpp.s...c.G....c.....Ah.h..s...sss.......s..............putL..K..........Vo.Fas........................shhG.sY.Vlt.....L...........D..........p.....-.......Y.......p.....a.......A.......l......V..........s.........u.......P........s......+.......c..........Y..........L..W....ILSRo.Ps..l.sc...p..h....hp.p.h.ls.hAppp..G.a.D..sscllhs.....................................................	0	154	272	396
+8045	PF08213	DUF1713		Mitochondrial domain of unknown function (DUF1713)	Mistry J, Wood V	anon	manual	Domain	This domain is found at the C terminal end of mitochondrial proteins of unknown function.	20.10	20.10	20.10	20.10	17.90	19.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.94	0.72	-4.34	23	504	2009-01-15 18:05:59	2005-03-29 14:01:14	6	5	475	0	231	276	2	32.90	55	24.09	CHANGED	pspSVhR+RRpKMpKHKaKKLpK+pRsLRR+Lc+	...hsSVlKKRRK+MsK+K+RKLl++TRhpRR+htc..........	0	74	139	193
+8046	PF08214	KAT11	DUF1714; RTT109; 	Histone acetylation protein	Mistry J, Wood V	anon	manual	Domain	Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal KAT11 protein (previously known as RTT109) which is required for H3K56 acetylation.  Loss of KAT11 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin [1]. KAT11 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast [1].  This family also incorporates the p300/CBP histone acetyltransferase domain which has different catalytic properties and cofactor regulation to KAT11 [3].	20.30	20.30	21.30	20.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.36	0.70	-5.37	34	515	2009-01-15 18:05:59	2005-03-29 14:08:11	6	56	258	9	340	491	6	297.80	30	21.94	CHANGED	LsshLtch..lPpstplsIRhluSssppspsh.sh.st..t....psphsa+pcthhshpphss.......................-lslFGlcV..Yso............sspRplalShhDSstah+............thcstshpphlluYL..s+pcsaspth................................................................................hhuh.sptuspYlF...PsspcsPc...........scpLhcWah+hL-phl.....................................pstlllssp-hacphthhsspsp..s.............................................................stsplPhFssD.hsphL--LhcE............................lpp.h-phthRpEhphuthsu.hhh......................ts......t.hppt..h+tshptht.....tshsssspts.pplhsc......lhpphp.tp..hhhlphptssptsspshhs	..........................................................................................p..hstst...plh...lRhlt.sssp.ps..cst.thht...t..h..p..pt...hspphs..Y+s+s...lhs.Fpc...l-G..............................s-VshFGh.aVpEYs.otss...........sNpRpVYlS..YLDSlpah+Pp......................thRT.tlY+.ElLl.u.YLc.a..s+p.h..G.a...spsa................................................................................IW.A.C.PP.p.cG..DDYIFa.sHPssQKhPK....................................sc+LpcWYp+hL-+uh......................................................................................tctllhsh......p.-hac.p.........sppcths.......................................................................................................ssppl.PaF-sDhasphlE-.lcE..........................................................................................lcp..-pht..hpp...p.t..s...t....s.th.................................................................................pt...pt....p...................p.p...t....t......h........................................s..........................................................................................................................................................	0	96	158	280
+8048	PF08216	CTNNBL	DUF1716;	Catenin-beta-like, Arm-motif containing nuclear	Mistry J, Wood V	anon	Pfam-B_13045 (release 16.0)	Domain	CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain (Swiss:Q8WYA6) is thought to have a role in apoptosis [1]. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localisation signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners [2,3].	20.50	20.50	20.50	25.10	20.40	18.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.19	0.72	-4.46	12	275	2009-09-11 07:46:25	2005-03-29 14:47:21	6	9	226	0	202	271	0	104.80	41	19.23	CHANGED	u-ccclslhchh-pstps.....EsLD-sslKKhlLsFEKRhhcNpEhRlKaPDsPEKFh-SElDLcchIpch+slAshP-LY..hV-LssVpSLlsLLuH-NoDIslsVl	........................t....t.phhphl-pptptt.......EslDtssl++hlLsFEK+hhKNtEhRhKasDsPpK..FM-SElDLcstIpphp....llAs.tP.-.....L.Y..hV.cL..s.sls.....SLluLL.u...H-NT.DIulssl..................	1	77	112	164
+8049	PF08217	DUF1712		Fungal domain of unknown function (DUF1712)	Mistry J, Wood V	anon	manual	Family	The function of this family of proteins is unknown.	18.20	18.20	18.30	18.80	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	604	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-13.03	0.70	-6.27	14	421	2009-01-15 18:05:59	2005-03-29 15:31:36	6	7	235	0	288	406	0	245.80	15	61.02	CHANGED	hhlFsss..hGppEGp..EhcKlLhaHP.......phslspKlpsIGlsEullpFTcsFossc.sCcs.....lcsp+pshlhhcsEssaWhshslp....p.csK-h.t.h..........hhpshL+psYphFphhpGshpuhhp.....t.scptLpshLp-ahhsah..pplp.hspp-hhc.hsol.................................QhLsLs+psaLplp................................uhlss....hssshsslt.hSshLap-pllhus.lusc-......................................................tphLasaslshhhshss.s-sus..hhpso.uhhh..sps..............h..hohsptsssspsph......................hsplal..............phcpppc.htlLhaphps.lslhlhhss.phhspp-hhpcLctplhpshoplhpslt.plsppts.st.tpcspsa..........+Ylh...hsptshth+ool.thhst.sp.s.tls.ssLcll...........................................s-lssttptu..p.tstttstEhh......................................................l+shsssWllt+psst+challLcph...................usol....l-lscplt+hsspah.sshF	............................................................................................p.....t........tplhhah...............................t....php.lGh.puhhthsp...h...s.t....t....p...........................lp..pp.p....hh.p.E..tha.h.....h.lp....................................................................h.t.l...hthahh..s...................................h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	100	149	222
+8050	PF08218	Citrate_ly_lig		Citrate lyase ligase C-terminal domain	Bateman A	anon	Pfam-B_3588 (release 16.0)	Domain	This family is composed of the C-terminal domain of citrate lyase ligase EC:6.2.1.22.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.12	0.71	-4.82	14	1051	2012-10-02 18:00:56	2005-04-01 14:24:12	6	8	898	0	105	1842	244	182.00	56	52.98	CHANGED	luuIVMNANPFTLGHpYLlEpAuppsDalHLFlVs-DsShFsap-RhsLlppGspcLsNlslHsGucYlISpATFPuYFlK-ps..sVhcspsplDlplF+chIApsLsIT+RYVGpEPhsplTshYNQtMpphLtpst.....Ipll.ltRp..ptsspsISASpVRphlccsshptltpLVPtTThpYl	...............................................IGsIVMNANPFThGHRYLlpQAAupC...D..W..LH..L..F..l..V....+...E...D....s..S....h.....F.s.Y..cDRhsLVhcGs.A..c..l...s...p...lTVH.p.G.S....-...YI....I...S...R...A...T...F..P..s..Y..Fl..KEpu..llsc..saspID..LpIFRpalAPALG.......I.THRFVG.oE.......P.......FCpVTspYN.QsM+hh.Lc.sss.s.ussIclVEItRl...........phpptsISAS+VRpLLscp....-.h.s.........AIusLVPssTLpYL.............................................................................................	1	27	54	77
+8051	PF08219	TOM13		Outer membrane protein TOM13	Mistry J, Wood V	anon	manual	Domain	The TOM13 family of proteins are mitochondrial outer membrane proteins that mediate the assembly of beta-barrel proteins [1].	25.00	25.00	36.80	35.60	17.50	16.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.75	0.72	-4.22	16	121	2009-01-15 18:05:59	2005-04-01 16:42:45	6	2	120	0	92	112	0	81.80	45	43.57	CHANGED	lshssDuEststhppps.s.pssusssh......slWull+uuuINLlLPFlNGhMLGFGELlAHEluFRasW......sGs+l.P.pRh	................................................................l...s-SEphs...s.pp...s...sssss..ssssh......................olaull+uuAINLlLPFlNGhMLGFGELhAHE.h.uFRh.GW.......sGsKlaP.pR+.................	0	22	47	77
+8052	PF08220	HTH_DeoR		DeoR-like helix-turn-helix domain	Bateman A	anon	Bateman A	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.51	0.72	-4.43	15	15183	2012-10-04 14:01:12	2005-04-05 17:40:47	7	49	3318	0	2086	11826	840	55.70	33	21.64	CHANGED	RpppIlchlpppGplolcELspthsVSstTlRRDLscLpppGl.lpRsHGGAthsssp	...........................RpptIl.p.h.l.....p..p..p...s..t..l..s.l..p.....-..L.u.p..t.....h..s.V..Sp...tTIRRDLs........p....L..pp.....pG....h....l...p...R...s....+G.GAhh...............................	0	573	1175	1649
+8053	PF08221	HTH_9		RNA polymerase III subunit RPC82 helix-turn-helix domain	Moxon SJ, Bateman A	anon	Pfam-B_9884 (release 8.0)	Domain	This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa [1]. This region is a probably DNA-binding helix-turn-helix.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.67	0.72	-4.10	18	285	2012-10-04 14:01:12	2005-04-05 17:50:21	6	11	249	2	200	310	6	60.60	30	11.07	CHANGED	pLsstllcpaaG-lsupVsstLlppGpholpplscpsp..LshspV+puLssLlQaphVpYhtp	.......................LsshllpppFG-l...ssclhstL.lp.p.G...p.s....lppls..p............pop.....ls....hc.pV+puLslLlQpslV.a.............................	0	63	106	160
+8054	PF08222	HTH_CodY		CodY helix-turn-helix domain	Moxon SJ	anon	Pfam-B_7573 (release 9.0)	Domain	This family consists of the C-terminal helix-turn-helix domain found in several bacterial GTP-sensing transcriptional pleiotropic repressor CodY proteins. CodY has been found to repress the dipeptide transport operon (dpp) of Bacillus subtilis in nutrient-rich conditions [1]. The CodY protein also has a repressor effect on many genes in Lactococcus lactis during growth in milk [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.02	0.72	-4.63	3	1097	2012-10-04 14:01:12	2005-04-05 17:50:46	6	4	1087	3	131	519	14	60.70	76	23.39	CHANGED	pEGRLTASsIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLN-pFl+ELcchK	...........EGhLsASpIADRlGITRSVIVNALRKLESAGlIE.S.R....SLGMKG.TYlKVL.ps.chh-ELcK.........................................	0	59	91	113
+8055	PF08223	PaaX_C		PaaX-like protein C-terminal domain	Fenech M	anon	Pfam-B_9563 (release 14.0)	Family	This family contains proteins that are similar to the product  of the paaX gene of Escherichia coli (Swiss:P76086). This protein  is involved in the regulation of expression of a group of proteins  known to participate in the metabolism of phenylacetic acid [1]. 	21.00	21.00	21.10	21.10	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.97	0.71	-4.57	63	785	2009-11-26 12:00:55	2005-04-06 08:39:11	6	3	636	5	203	603	67	159.20	26	55.33	CHANGED	tsW.......cGpWpllhh...sptptptRcplRcpLphhGFGplusulalpPsshtt...slpthltchshpsps..hhpsh......s....shpphlppsWsLsplsptYcpFlppapshh...............tptpt..hsstpsahtRhLLlHpaR+hLlpDPhLPpcLLPscWsGtsARpLhpslappltss	.....................................................................................tWcGpWhLllh...sthcpss+tpl+cp.....LthhGFGsLt....sulahpPsphtt.......................slpp.h...lt...c...h...sls...s...pl...hhhpup.....hsps.........shpshlp.....phWc...LsphsttYcp....Flppapshh...............ttttp....hsstps.hhhphlLl..ct...aRRhlhpDPh.LPt-LLPscWsGtpA.Rphhhshhpplt..h................................................................	0	55	122	166
+8056	PF08224	DUF1719		Domain of unknown function (DUF1719)	Mistry J, Myung-il K	anon	Pfam-B_27966 (release 16.0)	Domain	This is a domain of unknown function.  It may have a role in ATPase activation.	25.00	25.00	29.10	26.60	23.20	22.70	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.27	7	104	2009-01-15 18:05:59	2005-04-07 11:11:33	6	3	7	0	74	84	0	200.20	37	46.05	CHANGED	+pSuFPRRIAHATKShlSS.lhhsshDt.sopSsVRRFEhhADGAs-FLR.VEhGGo..P+pYhFFDPLIuHLLAGcsLcYchlp.Gsp.+hhhIRPhshtERGlEAhlhFshpsspsPccsFhLGhlLplSESTsllGhlI+CLQ.hhsPHF+SssEsV+pELsQLPTQDhoWl.sas..hc.haWDslHshtTpWaRPNPlCCppHs....t..toushshhtl.sh..psVIpl.lppal	............................psuFP+RlA...+As+ShlSS..hh..t.......t...s.-...p....op.............osVpRFEhFADGAs-FLRhl.E.h..Gus..spp..a.......h.h..hDPLlt+L.LAGctLpYc.h.hp....G....sp..............h.hh.hl..t..P.......h..s.ht-RGl....EAtlhhhhpDt..pts-psFhLshhLplSE.STsllGhhlpCLp...hhs...P..pFc..s.ssEss....+pcLspL.ppch...hh..P....h..........p......ahppl....Hph.ophhRPsPhCCcp.pp.........t...........t...t...t...t...t......th...EslIpl.hpt................................	0	0	36	58
+8057	PF08225	Antimicrobial19		Pseudin antimicrobial peptide	Rossi R	anon	Short protein clustering	Family	Pseudins are a subfamily of the FSAP family (Frog Secreted Active Peptides) extracted from the skin of the paradoxical frog Pseudis paradoxa (Pseudidae).  The pseudins belong to the class of cationic, amphipathic-helical antimicrobial peptides [1].	19.40	19.40	21.20	56.60	19.10	17.10	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.45	0.72	-6.81	0.72	-4.47	2	4	2009-01-15 18:05:59	2005-04-08 11:48:24	6	1	1	0	0	4	0	23.00	78	97.87	CHANGED	GlNTLKKVhQGLHEsIKLlsNHs	GlNTLKKVhQGLHEsIKLlsNHs.	0	0	0	0
+8058	PF08226	DUF1720		Domain of unknown function (DUF1720)	Mistry J, Wood V	anon	Pfam-B_19709 (release 16.0)	Domain	This domain is found in different combinations with cortical patch components EF hand, SH3 and ENTH and is therefore likely to be involved in cytoskeletal processes.  This family contains many hypothetical proteins.	21.40	21.40	21.40	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.26	0.72	-11.42	0.72	-3.92	66	116	2009-01-15 18:05:59	2005-04-13 14:45:25	6	24	75	0	89	133	0	78.20	31	8.31	CHANGED	hQP...............................QtTG............................pts..........sl.....psQsTG............hpP....................Q.TGh........................lpP....QtTGh..............................................t......h.pPQsT..............Ga	..................................................................s.ttp.....tlpsQ....TG...........hpP..........Q.TGa.....s.tt.....................LpPQpTGF........................t.h.pPQ.TG............................................	0	28	53	79
+8059	PF08227	DASH_Hsk3	DUF1721; 	DASH complex subunit Hsk3 like	Mistry J, Wood V, Finn RD	anon	manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.	24.00	24.00	24.70	28.90	23.50	23.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.82	0.72	-3.77	16	165	2009-01-15 18:05:59	2005-04-13 16:15:21	6	2	133	0	96	142	0	45.60	43	20.17	CHANGED	pRphupLtuQLspLpsNLuchpphLchsuhQs..pshctLGshpuuh	...sRphspLhhp.ptLstNlAphsp.LchhSlQs..hc.+FLuuhshu......	0	16	37	68
+8060	PF08228	RNase_P_pop3		RNase P subunit Pop3	Mistry J, Wood V	anon	manual	Family	This family of fungal proteins form a subunit of RNase P, the ribonucleoprotein enzyme that cleaves the leader sequence of precursor tRNAs to generate mature tRNAs.\	  The structure of Pop3 has been assigned the L7Ae/L30e fold [1].\	This RNA-binding fold is also present in human RNase P subunit Rpp38, raising the possibility that Pop3p and Rpp38 are functional homologs.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.02	0.71	-4.40	5	88	2012-10-10 14:40:03	2005-04-14 09:40:32	6	1	88	0	67	163	1	156.70	25	65.50	CHANGED	KR+QVYKPVL-NPaTNEAchWP+Vc-Q.lllELLpspll+sLl+hpc...Kss.-pclssGaNEIl-lLu..pusSc-V.....hLFVCs+D...PSVLloQlPLLstsushs....VsLVQLP+uupA+Fc-+l.GhS+s...GMLLV+ccAslDpsFsshlpspVEphshPWLcs	........................................................................................................................................................................................................................................p....l............hhu......hNplsphLp........ptss..p.h.................................hlFVs+pD..p.P.sl..LhpphPhLsh.h....Asts......................l+LVtLPKuu.splussL..Gl.s+s.....uhlulp..s.ss.s.hs.ps.LhchlpppVs.....l....p..hPWLp.........................................................	0	18	38	58
+8061	PF08229	SHR3_chaperone		ER membrane protein SH3 	Mistry J, Wood V	anon	manual	Domain	This family of proteins are membrane localised chaperones that are required for correct plasma membrane localisation of amino acid permeases (AAPs) [1].  SH3 prevents AAPs proteins from aggregating and assists in their correct folding. In the absence of SH3, AAPs are retained in the ER.	25.00	25.00	46.70	38.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.15	0.71	-5.35	17	149	2009-09-11 11:37:31	2005-04-14 11:25:11	6	2	130	0	110	144	0	193.30	34	90.31	CHANGED	Yp-hssluTuL.IlsuToFhLGllFushPYDashLWssssT.tptFDhuLpHYphhtsoP.hlhalLahVhhLGllGthIKLYKPst-spLF-YuSLsLYhlulslYlTNl+pGlpsshsGsWG.................-VspppGlsVlAASplhlhllLlGVLlLQuGhWYApac-ppphcpFhpcE.....tttttptppptcsppppspppK	...................................sshuThl.IlssosFhLGllFupaPYDaslLWsssso..ssa.........a.-hh.pHhp.h.las.......o.....Ps...hl.tlLpl...VhhlGllGhhhKLa.KP....sEushhFDGuSLsLYhhulsVY.lsNlhpGlcssss..staG..........................................................l..scps...u....LpV..l..AASNsIlsllLlGVLlLQuGpWY.Acpc-ppchcph.tcc.........tpttttttt...................pt.............................	0	35	64	95
+8062	PF08230	Cpl-7		Cpl-7 lysozyme C-terminal domain	Garcia Lopez E, Bateman A	anon	Garcia Lopez E	Domain	This domain was originally found in the C-terminal moiety of the Cpl-7 lysozyme encoded by the Streptococcus pneumoniae bacteriophage Cp-7 (Swiss:P19385). It is assumed that these repeats represent cell wall binding motifs although no direct evidence has been obtained so far.	25.00	25.00	39.20	25.30	22.80	23.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.92	0.72	-4.23	14	202	2009-01-15 18:05:59	2005-04-14 13:01:08	6	31	126	0	22	178	7	40.60	50	18.33	CHANGED	lcplApEVIpGpaGNGp-R+psLt..GaDhcAVQscVNplLs	..................lDplApEVIpG..caGNGp-R+p+L...GhsYssVQp+VNchL.....	0	8	8	13
+8063	PF08231	SYF2		SYF2 splicing factor	Mistry J, Wood V	anon	Pfam-B_11988 (release 17.0)	Domain	Proteins in this family are involved in cell cycle progression and pre-mRNA splicing [1] [2].	22.40	22.40	22.80	24.20	20.70	22.30	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.22	0.71	-4.09	26	339	2009-01-15 18:05:59	2005-04-14 14:01:54	7	5	283	0	231	317	2	149.80	35	56.19	CHANGED	cppGhDh-Rp+.hhshospcsEchcc+ccKKcpp..s.uassaspps.h+tYc+ph+sh..phDh-pYc+pKcphsct.............................FYsssssh..s.....pppPsp-A.l-+llpslc+pp....................cpRpKhpR+Rttc--t...DlsYIN-RN+pFNcKLsRaYsKYTsEI+pNLE	......................................................................t.ttGpDh.-+h+.hhchos--uE+..a-+Khc+Kptc...hGFs.sYsp.ts...h....+tYc+hh+pl........psDhEpY..c+p+ppt.s-t..........................................Fassus...o..lh..au...ppt..s.s.pcs..lDRhVp-Lccp.....................c+...RtKhpRR.Rhhs..--s.....Dl..s.YI.NE+NpcFNcK....lpRaYsKYTtEI+pslE..........	0	79	127	188
+8064	PF08232	Striatin		Striatin family	Mistry J, Wood V	anon	Pfam-B_7946 (release 17.0)	Family	Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (Pfam:PF00400) repeat domain [1]. It acts as a scaffold protein [2] and is involved in signalling pathways [1] [3].	27.00	27.00	27.30	32.00	26.70	26.10	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.79	0.71	-3.85	31	401	2009-01-15 18:05:59	2005-04-14 16:11:00	7	11	230	0	232	376	0	125.40	42	18.23	CHANGED	TLsGVh+aLQoEWp+hER-RstWElERuEM+uRIApLEGEp+s.cthppcLt++lchLEhslKpcRs+hpp............................................tt..t.tt..t.t.tsst.sp.stpspsphpcuR.hLpcshpElsY..hllss..s	.........olsGlh+alQpEWsRaEh-RspWElERAEhp.............A+IAhLpGER+upEs.LKpDL..sRRIKMLEaALKQE..R.AKh++L+hGs-hs........................................................................................ptp...........p..ps....tsp.p.t.st.......ttssphth+puRphL+........Q..a..LpElGY..pIlssp.s............................................................................................................	0	64	103	170
+8066	PF08234	Spindle_Spc25		Chromosome segregation protein Spc25	Mistry J, Wood V	anon	Pfam-B_14484 (release 16.0)	Family	This is a family of chromosome segregation proteins.  It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex [1], and in vertebrates it forms part of the Ndc80 complex [2].	22.30	22.30	23.60	22.30	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.27	0.72	-3.98	58	256	2009-09-23 13:20:45	2005-04-15 13:01:43	7	7	219	2	194	247	3	73.90	28	28.58	CHANGED	lcshts-p..l+FhFspl-sp-.p+E..hthslp.lss..ppYclhpssPpl...pslscllpcLN....cspshhtFl+phRctFtp	...........................hchhtt-p.LcFlFsp..lD.ps.-+c..hhFpLs..lsp.....ccYclhcspPpL....pslpcllcclN.......copshssFL+phRctFht............	0	62	110	157
+8067	PF08235	LNS2		LNS2 (Lipin/Ned1/Smp2)	Mistry J, Wood V	anon	Pfam-B_2646 (release 16.0)	Domain	This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins [1].  SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration [2], and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain [4].  Lipin proteins are involved in adipose tissue development and insulin resistance [3].	26.70	26.70	27.50	26.90	26.30	26.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.75	0.71	-4.66	16	814	2012-10-03 04:19:28	2005-04-15 14:14:50	8	20	307	0	473	726	11	147.40	44	17.04	CHANGED	VVlSDIDGTIT+SDsLGHhlshhG+D.Wo+sGlscLapclppNGYpIlYlTuRulGQAcpT+uYLppl.pts..pLPcGPllLSPsthhsuhhRElIh++PchFKhusLp-IpsLa............sppPFaAGFGN+.sDshuYpsVGlPssRIFhlNspGElhhp	...............................lVlSDIDGTIT..+SD..s......L.Gpl.l...........s...h...lG+..D....Wo..+.........tGlscLa.p..cl............ppNGY.phlYlouRul.uQAchT+uaLptl.p..t....s...............h....t...............LPcGPl.hhSPsphhsu.hp..REll..p+..cPc.tFK..hssL.p.........DIpsLF.............................................pppPFYAuFGNR.sDlhu..Yp..............pVGlP...s+IFhlsspuclh.............................................	0	132	208	346
+8068	PF08236	SRI		SRI (Set2 Rpb1 interacting) domain	Mistry J, Wood V, Sammut SJ, Bateman A	anon	Pfam-B_106465 (release 17.0) & pdb_2a7o	Domain	The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation [1].  This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilises the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation [2].	20.90	20.90	20.90	21.90	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.96	0.72	-4.04	25	233	2009-01-15 18:05:59	2005-04-15 16:03:34	6	10	207	2	167	246	1	90.50	28	7.69	CHANGED	psspphccpacp..hlupaVsNhlcKYccc.......ls+-shKphA+-ls+tLssKEhK.......pss...spsPstEloccpp+KlKpFs+pYMDKhltKhcp+c	..............t.tc+pcchacp..phutalsphlsta++p.......hscE-...hK+.h.A+cls+tlssK.E.hK.......psc......ss.shcls-......phc+KlKcalKcYhpKhssha+t.........	0	52	85	132
+8069	PF08237	PE-PPE		PE-PPE domain	Mistry J, Adindla S	anon	manual	Domain	This domain is found C terminal to the PE (Pfam:PF00934) and PPE (Pfam:PF00823) domains.  The secondary structure of this domain is predicted to be a mixture of alpha helices and beta strands [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.41	0.70	-4.93	32	715	2012-10-03 11:45:05	2005-04-19 14:46:55	6	11	138	0	135	708	1	213.70	31	45.55	CHANGED	P..shs...h.hl...hPt........thh......hssh..........ohspSlutGsstLpsAlpst...................ssss...hslhGaSQGAhlsst.htpLts..ssss....ssloFlhlGsPtps....sGGlhspass..hhlPh.....tlsassssPsss.........Ys....ThplstpYDuh.ADhPshPhNllAssNAlh.......G.hhhlH.........s.......sa.s...........s..s.....stshs.s.spstsusTTYhhlPsp..pLPLL.PL+.l.s.......lssslsshl-ssL+slV-tGYs	..................................................................psl...hPt....................phhPhss.......lssh....................ohs..pSV.spGs.s..Lc.sAI..t...s...t......................ssss...lsV...h...GaSQuAhlsshthpp..Lts...s.ssss.........................sspL.s.F.l.h.lGsPtpP..............sGG..lhtpas......s.............hh....lPh....................l.s..assssPsss......................Ys..........T.h.hsh.pYDGh.uD...h...Pp...h...P...h...Nl.l.....u.s.h.NAlh...........G..hhh..sH............s...........sa..shs......................................................stt...........stsl.hs..ss..uhs...usTs.YYhl.sp..pLPLL.PLRtl..s...............lsss...lsshlpssL+slls.hGY.......................................................................................................................................	0	19	73	122
+8070	PF08238	Sel1		Sel1 repeat	Bateman A	anon	Pfam-B_49 (Release 17.0)	Repeat	This short repeat is found in the Sel1 protein [1].  It is related to TPR repeats.	21.10	2.40	21.10	6.80	21.00	-999999.99	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.33	0.72	-3.19	594	40768	2012-10-11 20:01:00	2005-04-21 12:03:46	7	502	2506	23	13860	42646	6566	35.20	26	38.95	CHANGED	spAthpLG........h...pG...........l.p....s....hpp..AhpaappAAppGp	.......................................AthtLG..............hha.hpG.t.....................G..ltp.........D..............hpp.......Ah..paappAAptG.................................	0	6224	9270	11773
+8071	PF08239	SH3_3		Bacterial SH3 domain	Bateman A	anon	Pfam-B_178 (Release 17.0)	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.82	0.72	-3.78	263	10209	2012-10-02 18:48:24	2005-04-21 15:21:09	6	416	2914	9	1841	9471	1861	54.50	23	20.20	CHANGED	ssl..slR..ssP.sts...up..hlsp.......l..tG..pplpl....lp..ppss................W..hcl....................t.suh.p....Gal..t..sshlp	............................s..l..slR..ssP..uss...sp....llsp...................l..ppG......pp.lpl.............ls....ppss.........................................W.......hcl.......................p.sGp..p..........Gal..s...sphl...........................................	0	797	1353	1602
+8072	PF08240	ADH_N		Alcohol dehydrogenase GroES-like domain	Bateman A	anon	Pfam-B_7 (Release17.0)	Domain	This is the catalytic domain of alcohol dehydrogenases.  Many of them contain an inserted zinc binding domain. This domain  has a GroES-like structure [1-2].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.71	0.72	-4.29	92	42970	2012-10-01 22:45:51	2005-04-21 15:24:04	7	521	5327	455	13369	34065	8204	101.00	25	23.28	CHANGED	ss-Vll+lpssGlCsoDl..phhpG...............hhsphP.......hlhGHEhsGhV.p..lG.ssVps......hphG-+Vsl...shhs.C........up..............Ct.Cpp.Gp..shC.........................tphphhGhs..........hsGuaAEY.lhlP.......tptlh.l	..................................................s-Vll+lp.s.sGl..s.t..s......Dl.....th..h.pG.........................................h...ht.hP..............h.l..h.G...H...E...........s.....s..G.........h..Vh..p....l...G....s...s..V.s.s..............................h.c..sG...D.........+.V..s.s.......................s...........................................s.........s.....................t............s...............................................................................................u.....t..p..h...h.............h............................................................................................................	0	3704	7884	11039
+8073	PF08241	Methyltransf_11		Methyltransferase domain	Bateman A	anon	Pfam-B_21 (release 17.0)	Domain	Members of this family are SAM dependent methyltransferases.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.13	0.72	-3.50	172	22723	2012-10-10 17:06:42	2005-04-22 12:24:16	7	278	4590	31	8318	65769	22557	94.00	22	33.45	CHANGED	LDlG...sG.sGhhsthlspt.........stplhulDhstp.......hlp......hucpphttt.....................hhtus.......sppl..Pht.-s..oFD.hl...hsttsl..pah.......pc.ppslpEhtRlL+PGGhlhh	.......................................................................................................................L-lG...sG...sG..h..h..s...h..h..htpt........................stp.l....h..u......l....D...h...stt..............................h.lp...................h.u..p..p....p..h..t..t.t.t..t............................................................hht.u..s......................s.p..p..L...........P.....a.....s.....-....s............o......F...D.....h.l.....................h..s....t.....t.....s....l........pah..........................tc..h...t...p......s...l...p.....E....h....t......R....V....L.+.P.G.Ghhh...........................................................................................	0	2885	5512	7158
+8074	PF08242	Methyltransf_12		Methyltransferase domain	Bateman A	anon	Pfam-B_46 (release 17.0)	Domain	Members of this family are SAM dependent methyltransferases.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.27	0.72	-3.52	108	3160	2012-10-10 17:06:42	2005-04-22 12:25:33	7	531	1307	4	1307	38110	12780	102.00	25	6.03	CHANGED	L-lGsGsGthhthlhpt...................thphh.uhDhSsthl.....hstpchtphph.th.thphtthshhp..............................saDl....ll...sh.sllcah.........tshp.psLp..plt.phLps.uGhl	...................................................................LElG.uG.o.G....s...s.o.t.h.ll..pth.......................................th.c.Y.s....hoD...l......S...s.shl...........ttA.p..p............+....h...s....s....h........s..............h......t......h......t......h....h.....c..h.p..p..h..s..h..t.p.t.........................................................................................tsaD.l.........l...l......us....s.....V.L.Hss......................ppl...p...psL.p....plp...pl...L.p.P.GGhl...........................................................................................	0	345	748	1069
+8075	PF08243	SPT2		SPT2 chromatin protein	Mistry J, Wood V	anon	manual	Domain	This family includes the Saccharomyces cerevisiae protein SPT2 which is a chromatin protein involved in transcriptional regulation [1].	20.90	20.90	20.90	22.10	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.95	0.71	-3.78	7	281	2009-09-11 05:41:46	2005-04-22 12:54:49	6	7	216	0	195	268	0	106.40	30	22.63	CHANGED	Kpsshsh..ptpSt+t...s.ph-s-pDpchpcFIcD-cE-psch..........pccIhpIFshs+p+....ap..D--D.....MEAshtEl.cEEpRutRhAcLEDccE.ph.cEctppK+t+Kp+	...........................................................tt.........................pcp.cc...-....D...p-h..-.D..F..I...-D-t-ppc.p.......................ppt.IhthFs.h.s+p+.......Y..p....D.-....sD.......ptMEuuat-lpcEEt+St+lutpEDhcE....hchEcccp+c.Kct+Kt.........	0	57	95	152
+8076	PF08244	Glyco_hydro_32C	glycosyl_hydro2; Glyco_hydro_32; 	Glycosyl hydrolases family 32 C terminal	Finn RD, Mistry J	anon	Prosite	Domain	This domain corresponds to the C terminal domain of glycosyl hydrolase family 32.  It forms a beta sandwich module [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.12	0.72	-3.60	178	3225	2010-01-08 16:43:10	2005-04-25 13:01:37	7	49	1933	59	570	2522	88	88.70	22	16.56	CHANGED	hcls............................ssp.....th...Gltlhht..sstpcpstlhac................t.tppplslDRspou....ts.......ht.thss......hctshhtt...................tth..........................pL+lhlDcSslElFsssG	....................................................................................................ththtt..................h......th..l.h......tst..scthtlh.ac.............................t.tps..plslDR.opuu........t....................ht.thssh................scss.hsp..............................................................pt................................pLclhlDpSslElFsNsG...............	0	129	322	462
+8077	PF08245	Mur_ligase_M		Mur ligase middle domain	Bateman A	anon	Pfam-B_26 (release 17.0)	Domain	\N	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.40	0.71	-4.25	92	26660	2009-09-15 12:35:17	2005-04-26 11:46:18	7	94	4735	65	5962	19905	11199	195.10	21	41.78	CHANGED	lTGTNGKTTTsphltpll..ptt....st.hhsosG................s..t.lGlshhhhthtp.....tschhlhElSSa.......plpth.......hcsclu..lloNlsp-HL-..ha.toh-s.YhpuKtcla.ptht.ts......hsllN..h....DDt.....hhhthhpptthp.sl.sauhpsps...............lth..pssph...................................hh.h............hpl...slhG....p...aNltNsLAAluss	...................................loGTsGKTTTs...s..hl.splL.....pts.............Gh..ps...t.s...h.G.....................................................................s............l...s.h.s..h..h.h..h...h..htp........................tsc.h.hVh...Esu...p.t..................tplsth....................h.pP...p...lu.........l..l..TN.......l.s.h.D.Hh....-........ha....s.......s......h..-.s....ht.p.s.Ktp.....lh...c.t...h.............ts................h.s.l.ls....t.....-cs..............................hhp.h..h.....t...t..t....t...t...p......hh...t..a.u.h.p.tts....................th..t...tlt.h.........p..s.t.t.h................................................................................p.h.h..h............t...ht........hpl.......sl.G..........p......aNh....N.uhsAluh........................................................................................................................................................................	0	2011	3956	5101
+8078	PF08246	Inhibitor_I29		Cathepsin propeptide inhibitor domain (I29)	Bateman A	anon	Pfam-B_14 (release 17.0) 	Domain	This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide.  There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin Swiss:Q70SU8. This family is classified as I29 by MEROPS.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.98	0.72	-3.70	95	3417	2009-01-15 18:05:59	2005-04-26 17:20:04	7	34	536	17	1591	3509	92	58.50	30	16.86	CHANGED	FppahpcasKp..Y...............tsppE....ptpRh.phFtpNhphlppaN...........pspts.......a...ph........................................ulNcFuDhopcEa	............................appattpas+s.....Y........................tst.pE.....ctp..Rh.plFc.....cNhchIcpaN...........................tspto..............a......ph..........................................ul.N...pFuDhTp-EF........................................................................................	0	651	976	1322
+8079	PF08247	ENOD40		ENOD40 protein	Rossi R	anon	Short protein clustering	Family	Rohrig et al. reported the in vitro translation of two peptides of 12 and 24 amino acids from the short, overlapping ORFs of soybean ENOD40 mRNA [1]. The putative role of the enod40 genes has been in favour of organogenesis, such as induction of the cortical cell divisions that lead to initiation of nodule primordia, in developing lateral roots and embryonic tissues. This supports the hypothesis for a role of enod40 in lateral organ development [2].	20.40	20.40	22.70	22.70	17.80	16.30	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.84	0.74	-6.01	0.74	-3.79	4	11	2009-01-15 18:05:59	2005-05-03 16:13:00	6	1	7	0	0	9	0	12.30	76	100.00	CHANGED	McLCWQpSIHGS	...McLCWQKSIHGS	0	0	0	0
+8080	PF08248	Tryp_FSAP		Tryptophyllin-3 skin active peptide	Rossi R	anon	Short protein clustering	Family	PdT-3 or Tryptophyllin-3 peptide is a subfamily of the family Tryptophyllin and of the superfamily FSAP (Frog Skin Active Peptide).  Originally identified in skin extracts of Neotropical leaf frogs, Phyllomedusa sp. This subfamily has an average length of 13 amino acids. The pharmacological activity of the tryptophyllins remains to be established [1] but it seems that these peptides possess an action on liver protein synthesis and body weight [2].	17.70	17.70	23.10	23.10	12.50	10.90	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.28	0.74	-5.89	0.74	-3.17	2	8	2009-01-15 18:05:59	2005-05-04 09:25:07	6	1	5	0	0	8	0	12.00	75	91.43	CHANGED	EKPaaPPPIYPh	D.KPFWPPPIYPh.	0	0	0	0
+8081	PF08249	Mastoparan		Mastoparan protein	Rossi R	anon	Short protein clustering	Family	Mastoparans are a family of tetradecapeptides from wasp venom, that have been shown to directly activate GTP-binding regulatory proteins.  These peptides show selectivity among G proteins: they strongly activate Go and Gi but not Gs or Gt.  The peptide of this family are composed by 14 amino acids but they can assume different structures [1].	21.00	21.00	21.40	21.40	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.67	0.74	-6.03	0.74	-2.95	5	10	2009-01-15 18:05:59	2005-05-04 09:45:41	6	1	8	3	0	12	0	14.00	72	84.34	CHANGED	INLKAlAAlAKKlL	INLKAIAAhAKKLL	0	0	0	0
+8082	PF08250	Sperm_act_pep		Sperm-activating peptides	Rossi R	anon	Short protein clustering	Family	The sperm-activating peptides (SAPs) are isolated in egg-conditioned media (egg jelly) of sea urchins. SAPs have several effects on sea urchin spermatozoa: stimulate sperm respiration and motility through intracellular alkalinization, transient elevation of cAMP, cGMP and Ca++levels in sperm cells [1,2].	18.00	18.00	18.20	18.20	17.60	17.60	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.36	0.75	-5.62	0.75	-3.07	11	21	2009-01-15 18:05:59	2005-05-04 09:46:47	6	1	8	0	0	10	0	10.00	75	100.00	CHANGED	GFuLuGGGVG	GFsLsGGGVG	0	0	0	0
+8083	PF08251	Mastoparan_2		Mastoparan peptide	Rossi R	anon	Short protein clustering	Family	Mastoparan (MP) peptides I II and III are extracted from the venom  gland of the Neotropical social wasp Protopolybia exigua(Saussure) They are tetradecapeptides presenting from seven to ten  hydrophobic amino acid residues and from two to four lysine  residues in their primary sequences. These peptide cause the degranulation of mast cells. Protopolybia-MP-I also act causing hemolysis in erythrocytes.	25.00	25.00	26.10	26.10	16.50	15.00	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-6.18	0.75	-6.33	0.75	-3.35	2	5	2009-01-15 18:05:59	2005-05-04 09:49:55	6	1	3	0	0	5	0	14.00	76	100.00	CHANGED	INWLKLGKtV.shL	INWLKLGKtVIDAL	0	0	0	0
+8084	PF08252	Leader_CPA1		arg-2/CPA1 leader peptide 	Rossi R	anon	Short protein clustering	Family	In this family there are Leaders Peptides involved in the regulation the glutaminase subunit (small subunit) of arginine-specific carbamoyl phosphate synthetase.  In Neurospora crassa it is a small upstream ORF of 24 codon above the arg-2 locus [1]. In yeast it is the leader peptide of the CPA1 gene. The 5' region of CPA1 mRNA contains a 25 codon upstream open reading frame. The leader peptide, the product of the upstream open reading frame, plays an essential, negative role in the specific repression of CPA1 by arginine [2].	18.50	18.50	19.20	22.90	18.20	17.10	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.86	0.72	-6.75	0.72	-4.63	3	17	2009-09-10 15:06:03	2005-05-04 09:54:31	6	2	17	1	9	13	0	23.50	64	40.24	CHANGED	hstSsSQYTCQDYISDHIWKApSH	....FphS.SpYTCQDYISDHIWKoSS...	0	3	7	9
+8085	PF08253	Leader_Erm		Erm Leader peptide 	Rossi R	anon	Short protein clustering	Family	These short proteins are Leader peptides (15-19 amino acids) of  erm genes that code for resistance determinants in Staphylococcus  aureus [1].	21.00	21.00	24.90	24.40	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.28	0.72	-6.18	0.72	-4.47	5	32	2009-01-15 18:05:59	2005-05-04 11:41:20	6	1	23	0	1	13	0	18.80	80	82.42	CHANGED	MGhFSIFVIsTVHYQPNcK	MGhFSIFVINTVHYQPNcK.	0	0	0	1
+8086	PF08254	Leader_Thr		Threonine leader peptide	Rossi R	anon	Short protein clustering	Family	Threonine leader peptide of the Threonine operon thrA1A2BC.  It as been sequenced in different bacteria: E. coli, Serratia marcescens, Salmonella typhi [1,2].	25.00	25.00	25.40	26.20	18.50	16.70	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.04	0.73	-7.30	0.73	-4.09	2	68	2009-01-15 18:05:59	2005-05-04 11:43:54	6	1	68	0	8	11	0	21.20	87	98.63	CHANGED	M+hIS..TTIhTThp.TTG.GAG	MKRIS..TTIhTTITITTGNGAG	0	1	2	5
+8087	PF08255	Leader_Trp		Trp-operon Leader Peptide	Rossi R	anon	Short protein clustering	Family	The tryptophan operon regulatory region of C. freundii's (leader transcript) encodes a 14-residue peptide containing characteristic tandem tryptophan residues. It is about 10 nucleotides shorter than those of E. coli and S. typhimurium [1].	25.00	25.00	26.70	28.10	23.40	22.50	hmmbuild  -o /dev/null HMM SEED	14	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.06	0.74	-6.50	0.74	-3.84	4	51	2009-01-15 18:05:59	2005-05-04 11:48:22	6	1	51	0	5	7	0	14.00	71	91.30	CHANGED	MsuhhuL+GWWRTS	MKAIFVLKGWWRTS	0	1	2	4
+8088	PF08256	Antimicrobial20		Aurein-like antibiotic peptide	Rossi R	anon	Short protein clustering	Family	This family of antibacterial peptides are secreted from the granular dorsal glands of the Green and Golden Bell Frog Litoria aurea, Southern Bell Frog L. raniformis, Blue Mountains tree-frog Litoria citropa (genus Litoria) and frogs from genus Uperoleia. They are a part of the FSAP peptide family.  Amongst the more active of these are aurein 1.2, aurein 2.2 and aurein 3.1; caerin 1.1, maculatin 1.1, uperin 3.6 [1]; citropin 1.1, citropin 1.2, citropin 1.3 and a minor peptide are wide-spectrum antibacterial peptides [2].	20.60	20.60	20.90	20.60	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.89	0.75	-5.92	0.75	-3.03	14	32	2009-01-15 18:05:59	2005-05-04 11:52:33	6	2	7	0	0	29	0	13.00	62	70.70	CHANGED	GlhDlsKKVsGtl	GLFDIlKKVsGsI..	0	0	0	0
+8089	PF08257	Sulfakinin		Sulfakinin family	Rossi R	anon	Short protein clustering	Family	The sulfakinin (SK) family of neuropeptides have only been identified in crustaceans and insects.  For most species there is the potential for producing two sulfakinin peptides one have a short sulfakinin sequence The function of the sulfakinins is difficult to assess.  For the American cockroach, various forms of the endogenous sulfakinins have been shown to be active on the hindgut, and also on the heart.  In C. vomitoria the peptides act as neurotransmitters or neuromodulators, linking the brain with all thoracic and abdominal ganglia.  In adults of P. monodon they appear to be restricted to a few neurones in the brain with a neural pathway extending along to the ventral thoracic and abdominal ganglia [1].	21.20	21.20	21.50	21.50	18.50	20.80	hmmbuild  -o /dev/null HMM SEED	9	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.41	0.76	-5.79	0.76	-3.28	2	53	2009-01-15 18:05:59	2005-05-04 11:55:08	6	1	50	0	0	7	0	9.00	92	82.10	CHANGED	.-DYGHMRF	F-DYGHMRF	0	0	0	0
+8090	PF08258	WWamide		WWamide peptide	Rossi R	anon	Short protein clustering	Family	This family contain neuropeptides, isolated from ganglia of the African giant snail, Achatina fulica.  Each peptide has a Trp residue at both the N- and C-termini.  Purified WWamide-1, -2 and -3 showed an inhibitory effect on the phasic contractions of the anterior byssus retractor muscle (ABRM) [1].	19.40	2.80	19.40	2.80	11.30	-4.50	hmmbuild  -o /dev/null HMM SEED	7	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.27	0.77	-5.57	0.77	-2.79	2	19	2009-01-15 18:05:59	2005-05-04 13:22:39	6	2	2	0	0	18	0	7.00	83	27.71	CHANGED	W+pMSVW	WKQMSVW	0	0	0	0
+8091	PF08259	Periviscerokin		Periviscerokinin family	Rossi R	anon	Short protein clustering	Family	Abdominal Perisympathetic organs of insects contain  Periviscerokinins neuropeptides of about 11 amino acids. 	19.50	19.50	19.50	19.50	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	11	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-5.64	0.75	-5.78	0.75	-3.14	3	195	2009-01-15 18:05:59	2005-05-04 13:39:12	6	1	82	0	0	34	0	10.90	75	99.16	CHANGED	GSSGLIPFPRV	..GSSGLIshPRV.	0	0	0	0
+8092	PF08260	Kinin		Insect kinin peptide	Rossi R	anon	Short protein clustering	Family	These neuropeptides are the first members of the insect kinin-family isolated from the American cockroach. Their occurrence in the retrocerebral complex suggests a physiological role as a neurohormone. The C-terminal sequence Phe-X-Ser-Trp-Gly-NH2 characterised the peptides as members of the insect kinin family.  Data suggest a possible involvement of insect kinins in water-balance by regulating the osmoregulation. These peptides have length from 6 to 14 amino acids [1].	19.70	19.70	21.90	21.90	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-5.55	0.76	-5.53	0.76	-2.79	3	5	2009-01-15 18:05:59	2005-05-04 13:46:48	6	1	2	0	0	5	0	8.00	79	100.00	CHANGED	cPAFNSWG	DPAFNSWG	0	0	0	0
+8093	PF08261	Carcinustatin		Carcinustatin peptide	Rossi R	anon	Short protein clustering	Family	A total of 20 peptides of the superfamily allostatin were isolated from the shore crab Carcinus maenas. They are named carcinustatin 1 to 20 and their length ranges from 5 to 27 amino acids. This family includes carcinustatin 8,9,15 and 16.	20.70	0.50	20.70	0.90	20.20	0.40	hmmbuild  -o /dev/null HMM SEED	8	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.77	-5.30	0.77	-5.42	0.77	-2.46	2	2	2012-10-01 21:03:17	2005-05-04 14:12:48	7	2	2	0	0	66	0	8.00	88	2.84	CHANGED	uGPYuaGL	..AGPYuFGL	0	0	0	0
+8094	PF08262	Lem_TRP		Leucophaea maderae tachykinin-related peptide 	Rossi R	anon	Short protein clustering	Family	These peptides are designated Leucophaea maderae tachykinin-related peptides (Lem TRPs). Some were isolated from the midgut of L. maderae, whereas others appear to be brain specific.  The Lem TRPs of the brain are myotropic and induce increases in the amplitude and frequency of spontaneous contractions and tonus of hindgut muscle in L. maderae [1].  They were also isolated from brain-corpora, cardiaca-corpora, allata-suboesophageal ganglion extracts of the Locusta migratoria.  They stimulate visceral muscle contractions of the oviduct and the foregut of Locusta migratoria [2].	25.00	25.00	26.90	26.90	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	10	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.20	0.74	-5.42	0.74	-3.63	4	4	2009-01-15 18:05:59	2005-05-04 15:39:16	6	1	2	0	0	4	0	10.00	72	100.00	CHANGED	APSMGFpGhR	APSMGFpGhR	0	0	0	0
+8095	PF08263	LRRNT_2		Leucine rich repeat N-terminal domain	Bateman A	anon	Pfam-B_35 (release 17.0)	Family	Leucine Rich Repeats Pfam:PF00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.	20.70	3.10	20.70	5.20	20.60	-999999.99	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.56	0.72	-3.99	101	5573	2009-09-16 14:48:15	2005-05-06 17:06:28	7	2088	260	5	3276	5555	7	41.00	31	5.53	CHANGED	hss-tpuLLshKsulst.......ss....shLsuWsss........sssCs...WpGVsCs	........................p-tpALLphKp.u.ls....................ss.........shL..s..o...Wsss................sssCs.........Wp.GVsCs..............	0	335	1979	2672
+8096	PF08264	Anticodon_1		Anticodon-binding domain of tRNA	Bateman A	anon	Pfam-B_23 (Release 17.0)	Domain	This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.94	0.71	-4.46	171	17806	2009-12-15 13:50:21	2005-05-07 14:43:35	8	114	4976	36	4987	14537	7549	145.80	20	16.55	CHANGED	D+alLsclpphlpplspsh-.p.apaspshptlhpa...hhsphsshYlchs+sph.t.....................tslhpslcthlplLsPhhPaloEEla.......................t..........t.l..hh.....tt.a..P..p..........ptph............................................hphh.tl....lphhcp....hR...........sphpls.tstp......hphhl	..........................................................pphhhpphppslp.p.l.s.c.s.h..-.......p..acFspAhp.tlhp.F..........hhsc.hsshY.l..-..hs.K..s.h.h...htttt.t......................s...................ssl...h...p...s...l...c...s...l...l...+...llsPhhPalsE...E..lW...........................................................................ttt........pol....hh.......ss...a...Pp..s.t.h.........p.th.............................................................................tt.thp.h.h..t.l.........lp.s.htp.........hR...............sc.h.pls..sh........h...........................................................................................................	0	1700	3159	4209
+8097	PF08265	YL1_C		YL1 nuclear protein C-terminal domain	Bateman A	anon	Pfam-B_3088 (release 8.0)	Domain	This domain is found in proteins of the YL1 family [1]. These proteins have been shown to be DNA-binding and may be a transcription factor [1]. This domain is found in proteins that are not YL1 proteins.	20.60	20.60	21.30	21.00	19.70	18.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.05	0.72	-4.38	51	540	2009-01-15 18:05:59	2005-05-07 14:55:52	6	11	291	0	386	523	1	29.80	42	8.37	CHANGED	chCsITGh.ApYhDPpT.pl.Ytss-saphl	.....hCsITGLsApYpDPpT.pL.Ysss-sFphI......	0	114	198	309
+8098	PF08266	Cadherin_2		Cadherin-like	Finn RD	anon	Pfam-B_179 (release 17.0)	Domain	This cadherin domain is usually the most N-terminal copy of the domain.   	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.54	0.72	-4.41	77	2331	2012-10-03 16:25:20	2005-05-09 16:18:59	7	43	53	2	1054	2531	1	83.80	38	9.36	CHANGED	spl+YSVsEEscpGohVGNlAKDLGLslp-LusRshRllSpspcpahplshcoGsLllsE+lDREcLCupstsClLphplllEs	...........................................pl+YSlsEEhcpGohVGN.l.A.....c..D...L.....G....L....p.l.....t............c.....L......s...s....R.....p.....hR.ls..o..p..s......p......p.............phl.plshpsGt.L.h.l.s.c.+.IDR.E..pL..C...u........p....s.....s...t...Chlph-lll-.........................	0	88	224	576
+8099	PF08267	Meth_synt_1		Cobalamin-independent synthase, N-terminal domain	Finn RD	anon	Pfam-B_553 (release 17.0)	Domain	The N-terminal domain and C-terminal domains of cobalamin-independent synthases together define a catalytic cleft in the enzyme.  The N-terminal domain is thought to bind the substrate, in particular, the negatively charged polyglutamate chain.  The N-terminal domain is also thought to stabilise a loop from the C-terminal domain [1].	19.50	19.50	19.50	19.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.71	0.70	-5.16	56	2913	2012-10-01 21:20:02	2005-05-09 16:57:19	7	5	2719	25	628	4722	465	302.40	41	42.29	CHANGED	tspsLG.aPRIGtpRELK+AlEsYWpGchs...pp-LhpsucpLRtppWptQpssGlDh....lPsuDFoaYDaVLDtshhhGslPpRat.......t....sLDpYFshARGs....tsh...sAhEMTKWFsTNYHYlVPEhspsppFpls.ssphlp-hpEA.ptlG.h.....csKPVllGPlTaLhLuK....ststs....shhs.................LLppLlslYpclLpcLsstGsc.aVQlDEPsLshDl..spphhpshcpsYppL.........ttssscllLsTYFss.hscphshl..hpLPVs.GltlDlVc.uscpLssltp.ths..scKhLuAGll-GRNIW+sDLppsLphLppltpths	........................................................................................................h.sphLG.FPRlG.....p..RELKhAhEsYWt.....sc..ho.........c-...-Lhtsu+......-LRtcpWphQpp...s.G.l...Dh....lPs..sDFuaYD.pVLDsuhhh...GslPtRap............t..st..........ss....lDphFthuRGp...........................tsssAhEMTKWFsTNYHYlVPEas.p.s.........p..........pF.c......L.......s......h..s.......pll-EhpE.....A.....ps.L...G..h.............ps+PVLlGPl.....T...a...L..h...LuK...spsts........sths.............................................lLsc.LL.P.lYpplLscL.sc.t...........Gsc...WlQlDEP...s......L...V......h............DL........spp....h.......h......s....t....a....c......p.......s..Y.stL...................tpstsKlLLp..T..Y............F..ss..........l......t....c...........s..........h..stl....ss..L.P.Vs.GltlDhV.....c.....utcs.....L...s....tl...p.p......t.hs.................scphLsAGl....lsGRNlWRsDlppphshlcplht..t.......................................................................................................................	0	176	381	529
+8100	PF08268	FBA_3		F-box associated domain	Finn RD	anon	Pfam-B_322 (release 17.0)	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.94	0.71	-4.41	51	607	2012-10-01 23:07:08	2005-05-09 18:41:09	7	19	34	0	459	913	0	116.00	20	32.80	CHANGED	GlCING.VlYYhAhh..................sp.....phhlhsFDVRSEcF.shIph..................h..hthsLlsYcGKLuh..h..s..t........lclWVLE.DscK.pcWS.+pha...hhs.s..th.....hphplsGsTps.GE..llhh.........sphhppsFal	.......................................................................hsG.hlYah.s.......................t.......p.hlhsFDlp.sE.pF..p.hlph............................................t.t.hpL..l..ph....p..G....+.Luh.....ht.hpp.t............................hcl.Wl......Lc.....D...h..c..c..p.p.Wo.+h.hh......h.......................................................................................................................	0	120	175	213
+8101	PF08269	Cache_2		Cache domain	Finn RD	anon	Pfam-B_865 (release 17.0)	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.12	0.72	-4.01	34	2356	2012-10-01 23:40:40	2005-05-10 17:25:59	6	99	833	2	845	2155	121	91.30	24	17.47	CHANGED	+sshhpp+cppLpshlptAhshlphhtp.sptsphsc-pApppupphl..............pslRa.ssssYFalhDppsthlhHPhpPcL.Gpshts.hpDspGstlhp	................................................................thhpt+ctplpphl.p.hAhshlp.....hhpts..t......t..sth.s....cp.pA..p....p.p..u...hphl..................................psh..+...a....s...s....s......s.Y.h.a.l..h........D.....t....p.....s...s....h...lh.HP.h.ps..c.h...G.p.....s.hh.s..hpDsp.Gphlh..................	0	253	511	690
+8102	PF08270	PRD_Mga		M protein trans-acting positive regulator (MGA) PRD domain	Moxon SJ, Bateman A	anon	Pfam-B_5126 (release 7.7)	Family	Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1]. This corresponds to the PRD like region.	21.00	21.00	22.50	22.50	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.10	0.70	-5.07	13	638	2012-10-02 16:05:11	2005-05-11 14:46:11	6	4	320	0	27	325	1	210.10	29	43.86	CHANGED	spphlcchl...shplppo.hshh.shFpaaclLlulsaKR..+ta.lslPpstlh......cplpplhhhsplhpsspphlt.caslshspsslsYlFLsYloss.shu.sthhsppctcphhphhpchssaptLLc.lpctLshphss+pclhptL...saFp+p.lhshphLI.-hpthshptaptph.pLYptlcshlpcahpphst..ptplpppchahhshalEpl	...............s.p-.lsphl...shhhKposhshshspaphh+lLlshshhR..hsa.h-lspsph.......cphhshh.h.s...hh...ctstp.h-scaslshsp-sls.lFlsYhpsth.ls.p.hhpshccsphsc..hshp......hhs..pll-plptphtlphpN+spllhtL..........sahhRppLFs.phllh-p+t..slcpaps.a.phhss.lKp.lpcahpshph.....pshhspHhhYhhhh+hcpL........	0	5	10	19
+8103	PF08271	TF_Zn_Ribbon	TFIIB_Zn_Ribbon;	TFIIB zinc-binding	Finn RD	anon	Pfam-B_1298 (release 17.0)	Domain	The transcription factor TFIIB contains a zinc-binding motif near the N-terminus.  This domain is involved in the interaction with RNA pol II and TFIIF and plays a crucial role in selecting the transcription initiation site.  The domain adopts a zinc ribbon like structure [1].	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.38	0.72	-4.64	71	1235	2012-10-03 10:42:43	2005-05-11 16:17:32	7	14	529	7	745	1178	225	42.80	34	11.75	CHANGED	htCPpCsu.sp.l.....lhD...ppG-h.lCssC.GhVl--phl-pssEacsh	............h.hCPp..Css..s...l...........lhD.....p..pG-h.lCs.....pC.GhVl...p..-phlDttsEWRs................	0	230	423	611
+8104	PF08272	Topo_Zn_Ribbon		Topoisomerase I zinc-ribbon-like 	Finn RD	anon	Pfam-B_5615 (release 17.0)	Domain	Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to Pfam:PF01396. However, this domain no longer bind zinc.  Indeed, only one of the four cysteine residues remains [1].	25.00	25.00	28.90	28.90	19.10	16.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.72	0.72	-4.60	19	1903	2012-10-03 10:42:43	2005-05-11 16:18:39	6	10	949	2	262	1090	300	41.40	39	9.71	CHANGED	u.ssllpas++scppYlpoct.sGKhouWpsaapstcWpssph	.....t.splsp.p+pst..hlps.ts...sGh..hhuhssF.pstchpsshh.......	0	40	98	188
+8105	PF08273	Prim_Zn_Ribbon		Zinc-binding domain of primase-helicase	Finn RD	anon	Pfam-B_18441 (release 17.0)	Domain	\N	21.80	21.80	21.80	21.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.35	0.72	-3.88	18	651	2012-10-03 10:42:43	2005-05-11 16:18:46	7	22	488	2	103	533	210	37.60	54	6.24	CHANGED	t+HsPCPsCGupDta+.asDt.st.........GshaC.sC...u......sGDGh	......+HsPCPs.C...G.G....c..DRFR.FD.Dp...cGp...........GoWhC.N..pC......G......uGDGh............	0	21	44	78
+8106	PF08274	PhnA_Zn_Ribbon		PhnA Zinc-Ribbon 	Finn RD	anon	Manual	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.62	0.72	-4.16	34	2095	2012-10-03 10:42:43	2005-05-11 16:19:05	7	3	2023	1	331	1007	47	31.30	58	26.06	CHANGED	sL.....P...pCPpCsSEaoY............pDsslhlCP-CuaEWs	...........LP...sCPcCsSEYTY............EDsuhhlCPECAaEWs...	0	97	190	266
+8107	PF08275	Toprim_N		DNA primase catalytic core, N-terminal domain	Finn RD	anon	Pfam-B_313 (release 17.0)	Domain	\N	21.40	21.40	21.50	21.50	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.86	0.71	-4.19	93	4712	2009-01-15 18:05:59	2005-05-11 16:22:45	6	53	4423	10	1053	3634	2781	126.40	37	20.82	CHANGED	aapppLpssps.....AhsYLp.pRG.lstchlccFplGaAP...ps.........hptLh..phltp.cshs...p.lhpsGLltpppt..stha..Dp......F+sRlhFPIpctpG.cl.luFGGRsl..............sspp..s.KYl...NSPET.lFcKuchLY.uhtpA+	.......................................................................................................aapp.t.L.p.sstu...t....AhpYLp..pRG..lo..s.....-hl.pcF...tlGaAP....ss.............................hs.slh...chh......tp...pshsp....ptLh.cuGL.lhps-p..........sphY...DR..................F..R.s.R.lMFP...Ics...t..p.G....+V.lGFG..GRsL...................sssp...s.KYL...NSP...E.Ts.lFcKuc.LYultpA..........................................................	0	367	705	894
+8108	PF08276	PAN_2		PAN-like domain	Finn RD, Mistry J	anon	Pfam-B_291 (release 17.0)	Family	\N	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.89	0.72	-4.13	106	1792	2012-10-02 11:41:37	2005-05-11 16:56:24	6	91	83	0	773	1862	3	65.90	34	10.50	CHANGED	C..........tssDtFhplp.shKL..PDs.sth.hp.ps.hshc-CcppCLpsCSCTA..YAh..ssh......su......sGCllWp...u-LhDh	...........................................C.....psD.sFhp.hp..shK.L....P-.sp.t..s.h...hs......ps..hshc-Ccp.pCLp.sC.s.CoA..aA...sshp.....su..........sGC....llWh...s-.LhDh................	0	36	432	619
+8109	PF08277	PAN_3		PAN-like domain	Finn RD	anon	Pfam-B_1455 (release 17.0)	Domain	\N	21.10	21.10	21.10	21.80	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.68	0.72	-4.36	43	345	2012-10-02 11:41:37	2005-05-11 16:56:38	7	19	14	0	344	322	1	69.90	22	24.54	CHANGED	MlllaGpPssh....ss.phpshsacsClstChpsssCllsats...ss..sCthaph...ss.lsslpp...hpssssphl.AhKh	..............................MlhhaGpstsh........ss.tttshsappClppCapss.s...Cllsahs....ss........pChhaph.......ss...l....p...lpp.....hp...pss..t..t..hl.AhKh.....................	1	74	107	344
+8110	PF08278	DnaG_DnaB_bind		DNA primase DnaG DnaB-binding 	Finn RD	anon	Pfam-B_3213 (release 17.0)	Domain	Eubacterial DnaG primases interact with several factors to from the replisome.  One of these factors in DnaB, a helicase.  This domain has been demonstrated to be responsible for the interaction between DnaG and DnaB[1].	26.80	26.80	26.90	26.90	26.40	26.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.56	0.71	-3.92	90	1338	2009-09-10 21:47:29	2005-05-12 11:10:45	6	11	1330	3	256	893	235	126.70	34	21.41	CHANGED	s.hRtsluLLlQpPpLAttls..shtslpphp.s..uhslLhpLlphspp.psshsou.p.....LLEpaR...sssttphLppLAs...hp.phl..s--shpppFt-slspLhpp.h....lcpclppL..huKspt.ts..LospE..+pcLtpLl	.....shRhlIuLLlQNPpLAshVs......shtslcp.p..hP.......GlsLhp-.Llpssh...u..pPu.l.oTG.Q.........LLEpaR.....so.spsssLcpLut.................W-clh..-cs...h....hEppFsDoLs+lhcp.h.....lcp.chEpLhA+pRs...pG...LosEE..+h.ELhsL........................	0	50	142	210
+8111	PF08279	HTH_11		HTH domain	Bateman A	anon	Pfam-B_125 (Release 17.0)	Domain	This family includes helix-turn-helix domains in a wide variety of proteins.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.58	0.72	-4.32	103	12449	2012-10-04 14:01:12	2005-05-13 11:46:06	7	125	3577	14	2246	23862	1739	54.70	24	15.12	CHANGED	Rttpllph..Lhpscp..louppLAccLsV.Scpolh+DIptL.pttG.....h.Ituptsh..GYt	...............................pllph....L...p..s..p...p......l.......o.u.p.p......L.....Ac..p..l.....s.....V...Sc.....pTl....h+-l....p.t....L...pphs................h...l...u....t..th.....GY.........................................	1	790	1488	1900
+8112	PF08280	HTH_Mga		M protein trans-acting positive regulator (MGA) HTH domain	Moxon SJ, Bateman A	anon	Pfam-B_5126 (release 7.7)	Domain	Mga is a DNA-binding protein that activates the expression of several important virulence genes in group A streptococcus in response to changing environmental conditions [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.56	0.72	-4.21	16	958	2012-10-04 14:01:12	2005-05-13 11:47:10	6	23	527	3	56	1743	53	58.10	27	12.18	CHANGED	EccItcclcLlslLhc.ppphshs..-lscpLshothplpphlppLpth.Fscplthphpcst	................pKc.pRplp...LlchLhc..pphh.p....lp..ELuchLssoc+slps-Lsclppt..Fsp..h.hhp.pps.h...............	1	15	32	46
+8113	PF08281	Sigma70_r4_2		Sigma-70, region 4	Bateman A	anon	Pfam-B_125 (Release 17.0)	Domain	Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.16	0.72	-4.50	141	24630	2012-10-04 14:01:12	2005-05-13 11:47:27	7	126	3614	8	7611	38704	4348	53.10	25	25.60	CHANGED	tttltphlppLstpp+plhhLpthpshshpEIAphl.....sls.ssVcpplpRApppl	......................h...l.pslppL...s....t.c...p...R...p...s...l...h.L....p....h......h......p....u.......h.......o....h.....p.......EIAphl........s.l.s.h.uoV+splpRAppph...........................	0	3028	5560	6758
+8114	PF08282	Hydrolase_3		haloacid dehalogenase-like hydrolase	Bateman A	anon	Pfam-B_66 (Release 17.0)	Domain	This family contains haloacid dehalogenase-like hydrolase enzymes.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.36	0.70	-4.81	69	20961	2012-10-03 04:19:28	2005-05-13 16:17:25	7	63	4356	221	3153	23365	3191	223.30	21	85.03	CHANGED	lshDlDGTL.Ls..............pspp.ls.ppstpslpchpp........pGhhlslATGR..shhshhphhp.pLs..lp...hhhls...hNGuhl.....tpsphl.hpphls...pctlppllchhpphp.......hphhhhs...scshah.pt..........................thhhhtpthtthhhthtp.t.htspshhKlh.....hhtstpphpph..tpplppph.............shhpottthl-..lhspsssKupulptls..pthslshpcshAFGDutNDlpMlphu....GhulAMuNAspplKphAch..lsssssc.sGluchl	.........................................................................................................................................................................................................................lshDhDGT.L..Ls.........................................................s.p..p....p....l...s.........p.shps.l.p.p.h.p.p.........p.Gh...h.slso...GR...........h....h....t....h.....h..........h...h....p...p....lt....hp...........................hls..........N.Gu.hl................t.pt....p......h...l....hp...p......ls...................p...h.....p.lh..p..hhpp.t.............h.h.h.h..hs.........tp...th.hh.pt...........................................................................................................h...........h.................................t......................t....t....t....h.hchh..................h...p......t...t...h..t.th..........t..t...l...t...t....h.....................................phh..h...s...t...........h..l..-......l..h....t..s....s.....s...Ku....pu.......l....p......p.lh...........cp..h.............s.............l.......s.................p.....p.......s...h..A...h..G....D......sh....NDlpMl....p..h.s........G.h.u.l..A.M...s...N...A...t...s...p...l...K.t....h...A..s..h.....l..s..t..sspp..pGlhthl................................................................................................................................................	0	948	1870	2569
+8115	PF08283	Gemini_AL1_M		Geminivirus rep protein central domain	Bateman A	anon	Pfam-B_286 (release 2.1)	Domain	This is the cetral domain of the geminivirus rep proteins [1].	20.80	20.80	21.10	21.30	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.55	0.72	-4.21	13	2813	2009-01-15 18:05:59	2005-05-13 16:58:13	6	5	1027	0	3	2628	1	102.40	48	32.13	CHANGED	uQpsusDsht+Al..NusS+EEALsll+-chPc-aslphHNlpsNssRlF.csPEsassPFP.SS.FsplPEplp-WssspltpsSAt.hshR..SlllEG-SRoGKThW	..............................tpQoANDA.YAcAl..NuGSKpEALpll+EchPK...Dall.QaHNLsuNL-R.IFstPs.p.s..YlsPFs.SS.FspVP-Elp-Wss.-Nlh.....s.....u.....A....A..........R....P..........hRPhSIllEGD..SRTGKThW...................	0	2	3	3
+8116	PF08284	RVP_2		Retroviral aspartyl protease	Bateman A	anon	Pfam-B_	Domain	Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.57	0.71	-4.23	7	1125	2012-10-02 15:32:34	2005-05-13 17:10:21	6	93	68	0	570	1652	9	115.90	36	9.78	CHANGED	shspuRVNHlsAEpsQsuP-VlhGTF.VNSlPAoVLFDSGAoHSFIStsFVttHulth.pL+pPhhVpoPGsshpusphsPuVslcIpGlsF.us.IlLcSpsLDVILGMDWLspacGVIDCApRolsLTsspGc	........................................t............t.p.....t.t....t...l...lh..s..hh.......lps...hsshl..LhDSGAo.....HSFlSht.F.s.tp..p.t......h...t.h.p....p..L....p..p.....P..h.h.l....p.....o.....P.u...s...p...h.....p...s.....t..t...h..s...s...s...l..........s..l...c..I..p...s....h..s...F......u..s.L.I....l......L.-..s...c.......s.l...D...V..ILGMsWLspa.p.u.l.I.DC..s..p+plsl.t................................	0	109	151	165
+8117	PF08285	DPM3		Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)	Mistry J, Wood V	anon	manual	Family	This family corresponds to subunit 3 of dolichol-phosphate mannosyltransferase, an enzyme which generates mannosyl donors for glycosylphosphatidylinositols, N-glycan and protein O- and C-mannosylation.  DPM3 is an integral membrane protein and plays a role in stabilising the dolichol-phosphate mannosyl transferase complex [1].	23.80	23.80	25.30	24.90	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.00	0.72	-4.14	23	232	2009-01-15 18:05:59	2005-05-17 13:34:31	6	3	205	0	169	218	0	88.40	35	92.74	CHANGED	Mo+hpchlhhhshlsulahulhhshls....sp..hppll.hLPhahLVsFGsYuLsslGaslhTFsDs.-stcELhppIcEAKc.L+pKGlcl	..............................................MT+htphl.hhhllsu.......lahu..Lhhshls...................ls.....ppll..hLP..h.ahLVshGsYuLhplGatlhTFsD...ss-AtpELppcIpEA+t-Lpp+Glc..........	0	45	83	133
+8118	PF08286	Spc24		Spc24 subunit of Ndc80	Mistry J, Wood V	anon	manual	Family	Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex and is involved in chromosome segregation [1]	22.60	22.60	22.70	23.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.56	0.71	-4.40	24	178	2009-01-15 18:05:59	2005-05-17 14:02:25	6	1	166	4	123	167	0	116.60	28	57.89	CHANGED	lhcL-spphcluKphscLEsplppLpsplpcLppphp-lpppt.p................sscttt.......ss.cuslL+L+LYRsLG.lpl-t...t..........................-tspsl.I+spcpss.....lpslsl-s.phScaFhosYlWspL	................................................................pL-spphcluKphscLE...tp......hpp...Lps-LpcLcppht-L-ppth-...........................sppps.................stsuslL+L+lYRuLG.Icl-h..............................phspsl..I+sp...ccGs..............lpslslDs..phScaFhusYhWpth.........	1	32	62	95
+8119	PF08287	DASH_Spc19	Spc19; 	Spc19	Mistry J, Wood V	anon	manual	Family	Spc19 is a component of the DASH complex.\	     The DASH complex associates with the spindle pole body and is important for spindle and kinetochore integrity during cell division [1][2].	25.00	25.00	27.90	27.10	24.70	24.00	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.66	0.71	-4.60	20	131	2009-01-15 18:05:59	2005-05-17 16:15:36	6	2	128	0	99	123	0	146.60	35	82.74	CHANGED	oLsssVsSLpuSlplLcsS...lstLcsuspDhPRLs.pVLpTsRhFELlPEs-LppAppslh-EIpPplppLls+l-cplp+LpR+cpsLpsKhELppsRLpsspspssssptt......................s...h.sssspcltcL+tLppKKERLpYslpRL	.........LpssVsSLcuSlplLcsS...lphL-suspDhPRLs.plLpTsRaFELlPEsslppAptuLh-EIsPtls..pLls+scpplp+hpR+.psLpu+sE.LppuRLppspstssssstt.....................................tpt.shht.shsspc.htcL+tLppKK-pLpYsl-RL..........................................	0	24	52	83
+8120	PF08288	PIGA		PIGA (GPI anchor biosynthesis)	Mistry J, Wood V	anon	Pfam-B_6971 (release 17.0)	Family	This domain is found on phosphatidylinositol n-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with disease the paroxysmal nocturnal haemoglobinuria [1].	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.93	0.72	-3.62	23	340	2012-10-03 16:42:30	2005-05-17 16:20:46	7	6	290	0	246	348	6	87.90	55	19.14	CHANGED	HuYs.sRpGVRYLTNGLKVYYlPahVhYcpsohPThFusFPlhRsIllREpI-IVHGHuuhSoLuHEuILHA+TMGl+TVFTDHSLFGFAD	.................................HAYs.sRpG.VRYLTNGLKVYYlPhhVh...a...p...psThPTlFs.shPllRs.........Ihl..REpIp....IVHGHu.ohS.shsHE....Alh..H..A+TM..G..L+TVFTDHSL.FGFAD...................	0	86	132	206
+8121	PF08289	Flu_M1_C		Influenza Matrix protein (M1) C-terminal domain	Bateman A	anon	Pfam-B_30 (Release 17.0)	Domain	This region is thought to be a second domain of the M1 matrix protein.	20.80	20.80	20.80	23.80	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.21	0.72	-3.96	2	22741	2009-01-15 18:05:59	2005-05-18 12:08:22	6	2	22466	0	0	3048	0	94.30	91	38.38	CHANGED	pHRuHpphspoosPhlR+E.pMV.A.sTAKsMptMu....put-s.clApphpp.ltshRslGsp.psutGltpDlhEsLp..QppMG..s.hp+ah	......QHRSHRQMVTTTNPLIRHENRMVLASTTAKAMEQMAGSSEQAAEAMEVASQARQMVQAMRTIGTHPSSSAGLKDDLLENLQAYQKRMG..VQMQRFK.	2	0	0	0
+8122	PF08290	Hep_core_N		Hepatitis core protein, putative zinc finger	Bateman A	anon	Bateman A	Domain	This short region is found at the N-terminus of some hepatitis core proteins.\	 Its conservation of four cys and his suggests a zinc binding domain.	25.00	25.00	26.10	27.40	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.29	0.72	-4.51	2	5101	2009-09-11 06:29:00	2005-05-18 14:57:32	6	7	66	0	0	2681	0	26.90	96	24.69	CHANGED	hphFpLCLIISCoCPThQASKLCLGWL	....MQLF.HLCLI.ISC.S.CPTVQASKLCLGWL.....	0	0	0	0
+8123	PF08291	Peptidase_M15_3		Peptidase M15 	Finn RD	anon	Manual	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.40	0.72	-4.25	19	623	2012-10-02 01:02:30	2005-05-19 09:30:08	6	14	470	1	168	1206	1181	110.70	24	47.23	CHANGED	taFphpEhspsssssppslD...............plhshLpslRcpaGp..........PIhloSGaRssthNppVGGApsStHhpG.....pAADlpshst.sspcltphhc...sphstch....Ghttts....salHls	..........................................................h.....tt...............t.h.............................thhphL...ctl.Rp.t..h.st..........Pl.h..l.o..........SG.......YR........s...phN.......c........p.....l........G....G......u.....s.....s.....S.pHh..hG.........pAuDltls..........sh.....s.......p.l..t....p.hht......ph.h.....t...........hh...t..........talHls.............................................................	3	78	128	153
+8124	PF08292	RNA_pol_Rbc25		RNA polymerase III subunit Rpc25	Mistry J, Wood V	anon	Pfam-B_9841 (release 17.0)	Domain	Rpc25 is a strongly conserved subunit of RNA polymerase III and has homology to Rpa43 in RNA polymerase I, Rpb7 in RNA polymerase II and the archaeal RpoE subunit. Rpc25 is required for transcription initiation and is not essential for the elongating properties of RNA polymerase III [1].	24.20	24.20	24.40	24.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.37	0.71	-3.92	33	328	2012-10-03 20:18:03	2005-05-19 09:32:39	7	9	290	3	240	371	3	116.40	35	51.74	CHANGED	PFhGEllpG.pIpssopcGI+Vol.uFF-D.........IalPhs.L......-sspa..cpp-psWlWpht................-ppchahDhsEplRFRVppphF..-.pPhs.t..........................ttttpttppphssatll.GShppsGLGhloWW	..............PFhuEllhG.+Ipsso.t.cGl+lol.sFF-D.........IhIPsphL....................psu...p....F............-ps..-..p...s...WlWcht.........................pspcLahDh.sEplRFRVppE.a.hD.pPtssp...............................................ttt....tttpp.sPYplh.GShppsGLGhluWW..........................................	0	82	132	196
+8125	PF08293	MRP-S33	Mit_rib_S27; 	Mitochondrial ribosomal subunit S27	Mistry J, Wood V	anon	Pfam-B_31036 (release 17.0)	Family	This family of proteins corresponds to mitochondrial ribosomal subunit S27 in prokaryotes [1] and to subunit S33 in humans [2]. It is a small 106 residue protein.The evolutionary history of the mitoribosomal proteome that is encoded by a diverse subset of eukaryotic genomes, reveals an ancestral ribosome of alpha-proteobacterial descent that more than doubled its protein content in most eukaryotic lineages. Several new MRPs have originated via duplication of existing MRPs as well as by recruitment from outside of the mitoribosomal proteome [3].	25.00	25.00	25.10	28.20	23.20	24.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.07	0.72	-4.01	30	282	2009-01-15 18:05:59	2005-05-19 09:52:05	6	4	245	0	194	253	2	88.60	34	73.37	CHANGED	shhhclscluu+IFupshNPsstRoGs..KlLppcL..+Gspls...sYY..Psth.papphcphhs..thhhhD.cEsh....Rhphlch.................+KtRGKGsP......KK	...............hhhchs+Lps+IFupshp..Ps.st+ohp...Klhppc....+sspls...saY....Ppchhhh.t.h.pphh...............hhhhhDEcpch....+.chhch.................+KhRGKGtP.....KK................................	0	58	99	154
+8126	PF08294	TIM21		TIM21	Mistry J, Wood V	anon	manual	Domain	TIM21 interacts with the outer mitochondrial TOM complex and promotes the insertion of proteins into the inner mitochondrial membrane [1].	20.40	20.40	20.90	21.10	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.70	0.71	-4.54	13	289	2012-10-01 19:51:31	2005-05-19 10:32:58	6	5	252	1	206	280	0	136.30	30	55.74	CHANGED	Kl+cssphoh.hhlVluGlGloGlllYlIhsELFSsSucspIFN+AlpplcsctcspslL........GcplKuaGEtsppsR..RsRshVSppch-+cGhcHhhM+FHVEG..s++pGhVplEhpcsstp..hp.-Fhaha..lDlssc++Ihlhcs+	...............+ltcssppss.hhlllhGlulo.uslhYhl...apELF.u.s.s.Sssplas+Alc+lcpcscl.hshl...............Gp..l+...uYG..E..t..op...s+.....R.hs.op.h.p.h..c..+..c.Gh.......cHhphpFalcG..stppGhVph-hhcs.tp......tpa.-apalh..l-s.......s....p..p.p..hhl.p.....................	0	62	107	166
+8127	PF08295	Sin3_corepress	HDAC_interact;	Sin3 family co-repressor	Mistry J, Wood V	anon	Pfam-B_2731 (release 17.0)	Domain	This domain is found on transcriptional regulators.  It forms interactions with histone deacetylases [1].	25.00	25.00	26.90	25.50	22.80	23.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.39	0.72	-4.26	26	505	2009-01-15 18:05:59	2005-05-19 10:38:32	7	10	275	0	333	477	4	97.90	45	7.99	CHANGED	sCcphGPS....YRhLPKs...s.CSGRschs...tpVLNDpWVShPohu.ED.tuFhshRK.NQYEEsLa+sEDERaEhDhllEuspsoIchLEplhpclpshspc-cts	.........................pC+phGsS....YRhLPK.s..htt...CSGRstLC..................ppVLNDpW.VSa.P.oWu..E....D.S.s.Flu.p........+.K..sQYEEpLaRsEDER..aEhDhllEsshs...TIphLEsltp+ls.pho.c-p..p...................................	1	122	194	269
+8129	PF08297	U3_snoRNA_assoc	U3_snoRNA; 	U3 snoRNA associated	Mistry J, Wood V	anon	manual	Family	This family of proteins is associated with U3 snoRNA [1]. U3 snoRNA is required for nucleolar processing of pre-18S ribosomal RNA.	25.00	25.00	27.30	27.30	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.80	0.72	-3.75	21	98	2009-09-11 16:06:36	2005-05-19 11:16:19	6	3	96	0	72	97	0	90.70	27	29.00	CHANGED	chLP--lLsshspssssss.tps....................h.tpphKtpKh+hLcphcK..psl+hGsVslpVLsspsst.....pLsPKucppshssK-pWLpRp	............thLP-ElLps.sppc...sss.tpp............................tpp...hcspKh....+hLcphcK.....csl+hGsssl+VLssssst.........pLsPKspppshpsK-pWLpR.....	0	10	33	61
+8130	PF08298	AAA_PrkA		PrkA AAA domain	Vella Briffa B, Bateman A	anon	Pfam-B_3917 (release 10.0)	Domain	This is a family of PrkA bacterial and archaeal serine kinases approximately 630 residues long. This is the N-terminal AAA domain [1].	19.70	19.70	19.70	19.70	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.18	0.70	-5.76	7	1391	2012-10-05 12:31:09	2005-05-20 09:52:18	6	8	1305	0	343	3100	1561	347.80	58	55.27	CHANGED	hoht-YL-hs+ps.pshtsAtcRlhshIt-s....hlcsttp.+lt+latNcsI++YshFs.-FaGhE-sl-+IVs.YF+tAAptLEE+KQILYLlGPVGGGKSSLsEpLKplhEhh......PlYsL.....ctsPhaEpPLpLh.PpchtphhEccaGI...clpG.hSPhsshRL.cEFGG-IpcFpVsKlh.ShhpphuIupspPuD.NNQDlSsLVGpVDIpKl-pY.upsDPcAYSasGuLN+uNpGlhEFlEMFKssIKhLHsLLTATQEGsasustphuhlsFsGlIlAHSNEuEWtpF+sN+sNEAhlDRIhllcVPYCL+loEEhKIYEKlLppSplsps.hAPcTL-hhuhFolLoRLpps-pSs	................................................................................................oLpEaLs..lC+pD.oAYAsAuERlLhAIGEP...phlDTup-sRL.S.....R.l.F..............u.N..+.l.I.t.R.Y......P.u.F.......c........-.......F.......Y..G..ME-AIEQIVu.Yh...+H...A.A.Q.G.L..E..E.+K.Q...I..LYLLGPVGGGKSSLAE.+LKpLM.pph..........PIYsL.............................ctSPVp-cP.L....sL......F.sPpE......Du........p........l........L.........-.........c........E.......YGIP....................pRYL.tsIMSP.....W...A....s....K....R...L.....c...E..............F.....G..GD.........I.....o.....+.....F.......+...V.......V......K.......l.........aP........SILpQ...IuIAKTEPGD..E...NNQDISuLVGKV...D...IRKLEc.a..uQ.sDPDA.YuY.S.GuLC+ANQGlMEFV.EMFK...APIKVLHPLLTATQEGNYsGTE.GluA.lPFsG.lILAH..SN..ESEWhoFRNNKNN...E..A..FLDRl.YIV..KVP....Y..C..LRlS.EElKIY-...KLL.pcS.-Ls....c..AsCAPu.TL-sL.............upFSlLSRLKEPENSs...................................................................	1	95	198	277
+8131	PF08299	Bac_DnaA_C		Bacterial dnaA protein helix-turn-helix	Finn RD, Bateman A	anon	Prosite	Domain	\N	20.60	20.60	20.90	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.02	0.72	-4.12	14	4828	2012-10-04 14:01:12	2005-05-20 13:18:53	6	14	4481	14	1038	3266	2314	68.70	46	15.45	CHANGED	olcpIpcsVA-haslslp-lhScsRs+slspsRQIAMYLs+pLTspSLPcIGctFGGRDHTTVlaAsRKI	.............................l-sIQct.VAcaa.plpl.pDl.hu.p..+R.s.+.s.l.sp.PRQl.A.M.YL.u+EL..T.s.tSLPcIGctFGGRDHTTVlHApcKI..............	0	367	704	891
+8132	PF08300	HCV_NS5a_1a		Hepatitis C virus non-structural 5a zinc finger domain	Paterson M, Bateman A	anon	Bateman A	Domain	The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2]. This domain corresponds to the N-terminal zinc binding domain [3].	20.70	20.70	20.90	21.10	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.30	0.72	-4.06	19	5702	2009-01-15 18:05:59	2005-05-20 13:58:15	8	39	117	6	0	5232	0	61.60	83	5.83	CHANGED	lPFlSCQ+Ga+GsWcGDGlhpTpCsCGA.IoGcV+NGoM+..lsGP+hCSNhW+GTFPINshTo	...lPFlSCQRGYKGVWRGDGIMpTpCsCGApITGHVKNGSMR..IVGP+TCpNhWpGTFPINAYTT......	0	0	0	0
+8133	PF08301	HCV_NS5a_1b		Hepatitis C virus non-structural 5a domain 1b	Paterson M, Bateman A	anon	Bateman A	Domain	The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525 [1,2]. This region corresponds to the 1b domain [3].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.02	0.72	-3.66	20	10555	2009-09-11 00:37:05	2005-05-20 14:01:38	8	41	117	6	0	7446	0	68.20	85	10.02	CHANGED	GPusPhPuPNYppALWRVuAc-YVEVpRlGDaHYVsGsTsDsLKsPCQVPuPEFF..TEVDGVRlHRaAPsC+PLLRDEloFoVGLsuaslGSQLPC-PEPDV	...................................................................................PLLR-E.VoFpVGLNpYhVGSQLPCEPEPDV...........................	0	0	0	0
+8134	PF08302	tRNA_lig_CPD		Fungal tRNA ligase phosphodiesterase domain	Mistry J, Wood V	anon	Pfam-B_49998 (release 17.0)	Domain	This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity [1].  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.	21.30	21.30	21.50	21.30	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.89	0.70	-5.17	19	168	2009-01-15 18:05:59	2005-05-20 16:00:11	6	8	142	0	119	174	3	219.00	25	29.09	CHANGED	SShcNlcpVlspL+ptYPpLl...clPosp-lDpAlphAhstY+Pshc+shshsspp.tpp....pp.........................ss.cppp+plcYaulsl.sspclpshLcshhs.s....ss-pt+hacpLhss+RlQspFHVTLIH+AupKp.pP...clWcpYsphahsphpppspsp.............h.shussclcL-+Ll.WDD+lMshlsclh...s.p...........ssa..tCsNplsHITVGThuspVKP+ESN-LLp+ah.......p.tGous-...sGlhphplsGshllpGsVthsh	.................................................................................ShtNhchllptl.t.aP.lh....phPsspphctAhp.uhp.Yp.sphp+.ht.t..t......................................t.pt.h.htp.pYhul..pl....s.pplhphlpphhsss......st.tp.happLhtspRl....Q.ph...HVTLhHpsstpp......p......plWpphhphatt.thtpt..t...............................st...splpL.c.+ll..aDc+lhAlssc.lhs.......................................sph....ssN.p.hsHITlGTtpssVKPhESNcLLpchh........p...sst.t...ttl..h.h.............................................	0	38	71	101
+8135	PF08303	tRNA_lig_kinase		tRNA ligase kinase domain	Mistry J, Wood V	anon	Pfam-B_49998 (release 17.0)	Domain	This domain is found in fungal tRNA ligases and has kinase activity [1].  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.	22.70	22.70	22.70	22.80	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.11	0.71	-4.38	9	141	2012-10-05 12:31:09	2005-05-20 16:00:33	6	7	132	0	106	153	2	160.00	43	19.71	CHANGED	lllPIATIGCGKTTVuhsLpsLFsp.WuHlQNDNI.ouK.sps+hh+psLchL....t+csppsVlsDRNNHph+ER+QLF-.lpph+-pals.s.sl+hlulsFlc.c.phpElh-lThsRVhpRGDNHQSIKspo.stp+VhtIMpGFlKRaQPls.s.+pPDspFDhlIcLclu	.................lLVPIAoIGCGKTTlulALscLF...s.....WGH....lQNDNI.suK.tcs.cFscpsl.phL......tspssVlAD.................RNNHpp+..ERcQ...lhs...slpp.........hp.........................ss...+hlALpa.scps.......lscl+clTtpRVlpRGDNHQTI+..uso...sp..pcl......huIMcGFlpRFpslssp.pp.......P........DstFD.lIcL-..s.........................................	0	32	63	93
+8137	PF08305	NPCBM		NPCBM/NEW2 domain	Rigden D	anon	Rigden D	Domain	This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins. This domain has also been called the NEW2 domain (Naumoff DG. Phylogenetic analysis of alpha-galactosidases of the GH27 family. Molecular Biology (Engl Transl). (2004)38:388-399.)	21.20	21.20	21.20	21.20	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.65	0.71	-4.23	43	539	2009-01-15 18:05:59	2005-06-23 15:31:28	6	113	262	16	146	530	40	138.50	24	18.44	CHANGED	ss.sssshL...SDlsh..hou....ssGWGslp+Dpus......supsLslsG.........psasKGlGsHAs..SplsYsL.Gst.hspFpAhVGlDcp...hssp..GoVhFpVh...sDG..pplasSss.....hpsssssptl.slDl.....sGspplcLllssuG.su.ssDHusWusA+ltp	.............................................................ss..t..hlo-h.h....ps......tsth.t..s.hp.t..sts..........psp.lplts........hpa..s+.....GlGs.....p.....As.............S......plh.....Yslp..u...t.t...hspFp...uhl.G.lDcp................hssp.......sslpFpVh...........sDG......chla.sSss........hphss...ss.thl..slsl.....pGspplcLhss.s..uG..ss.s.t.t.Dc..ssaussph....................................................	0	74	114	142
+8138	PF08306	Glyco_hydro_98M		Glycosyl hydrolase family 98	Rigden D	anon	Rigden D	Domain	This domain is the putative catalytic domain of glycosyl hydrolase family 98 proteins.	21.00	21.00	21.10	21.10	19.10	20.90	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.11	0.70	-5.73	6	208	2010-01-08 16:43:45	2005-06-23 15:32:49	6	15	206	14	11	93	0	299.60	59	31.09	CHANGED	uhhssssspsss...shRRsISsEpPhhhl.l.u............Wssss.pthh-hIPsDl+PYTVlpLp.u........ls+c-usup......chhEphlEpApSal..KTstspsl.shlps.SuG..chPsYsssspLpos....hh-EhFpcYPNhhGh..sEpaWsassshu.......sHhAphLKLosKYGGYh.......hWusp.NshAhtK.......psssFppAlcpYt+NFIhtpK.TsptshpD..sESlshGhWLSGaAspaGhphDohtWYEpt...........pupGs+pasststAhhhIE..plhLsGtTVash.chhaT.sVpspss...............PtFsNlhh-hFR+lIsssh.	................h.......s...s...thRp.lss-pPhhh..h.s...............................Ws.ss.KGAWEAIPEDVKPYAAIELHPAKVCKPTSCIPRDTKELR......EWYVK.MLEEAQSL.........NIPVFLVIMSAG.....E......RNTVPPE.................WLDEQFQKYSVLKGVLNIENYWIYNNQLA..........PHSAKYLEVCAKYGAHF.......IWHDH.........EKWFWETIMNDPTFFEASQKYHKNLVLATKNTPIRD..DAGTDSIVSGFWLSGLCDNWGSSTDTWKWWEKHYTNTFET...GRARDMRSYASEPESMIAMEMMNVYTGGGTVYNFECAAYTFMTNDVPT................PAFTKGIIPFFRHAIQNPAP......................................	1	6	6	8
+8139	PF08307	Glyco_hydro_98C		Glycosyl hydrolase family 98 C-terminal domain	Rigden D	anon	Rigden D	Domain	This putative domain is found at the C-terminus of glycosyl hydrolase family 98 proteins. This domain is not expected to form part of the catalytic activity.	25.00	25.00	25.00	25.90	23.20	23.90	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.78	0.70	-5.12	3	232	2009-01-15 18:05:59	2005-06-23 15:34:03	6	14	206	9	16	109	0	224.00	53	25.82	CHANGED	KpEVlsRTKuVlasshTp.NGpGpYSS.pshFsGLY......TphsQpPhY.sTGRYssIPsVappID+pKIuSpFPsu.hKllocNSoELSSIssKspYLNuLYPcEYsGDlYAQRlDNoWaIYN.sYNpNKNQpGuFslhhNNsKSLslTLsPHTYuVVcENssuLsIhLNNYRT-KsuLWthutNhDtuKph.chpcl-hhNWl.csY.hNssss-hRToTITLpGtousPThoNlsGD+GcYshsTVsasssT+uhTITVsHNGslDhoIssc	........KEEVlsRTKsVha......NGpG+...hSS.pshapGLY.............oscEshPLY..ssGRYpllPVIa-hlDp-KlushFPsu..KI.......locsSpEhSS...KVsYLNuLYPc..YEGDhYAQRlsNoWalYN.sss.N...hN.........KsQps.hLPhhhN.sscS.LoL-hoPHTYuVVKEps.N..sL+IhLNNYRT-Ksuh.........Wu.utshstuKph.phpchthhpW.IpcpY.hs.......s..ss-hRTTTlTL+Gtoup.s.hslSGD+......NcYsh...T......NaDpssHVhTITVNHNG.lEhoIssp......	0	8	8	11
+8140	PF08308	PEGA		PEGA domain	Mistry J, Adindla S	anon	manual	Domain	This domain is found in both archaea and bacteria and has similarity to S-layer (surface layer) proteins.  It is named after the characteristic PEGA sequence motif found in this domain. The secondary structure of this domain is predicted to be beta-strands [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.30	0.72	-4.19	32	1445	2012-10-02 19:08:27	2005-06-23 15:51:23	6	105	449	0	727	1662	573	68.30	22	20.63	CHANGED	huslslsSsPpGApVhlDG.thhG...pTPh.sls.lssGp+plplphpGYtsappplplp.sscshplphp..Lp.tp	.............................tlplpS.sP.t..u..ApV.h..l....s...G.....p..h..h.G...........pT.....P.......h....p.....l....t...............l..s.....s...G.......p....a..p.......l..p.l.p..t...p..G..Y.p.s..h.p..p.pl..plp..ss.p.p.h.tlpht..................................................	0	322	491	635
+8141	PF08309	LVIVD		LVIVD repeat	Mistry J, Adindla S	anon	manual	Repeat	This repeat is found in bacterial and archaeal cell surface proteins, many of which are hypothetical.  The secondary structure corresponding to this repeat is predicted to comprise 4 beta-strands which may associate to form a beta-propeller [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  The repeat copy number varies from 2-14.  This repeat is sometimes found with the PKD domain Pfam:PF00801.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-8.00	0.72	-4.97	22	449	2012-10-05 17:30:43	2005-06-23 15:54:39	6	46	137	0	309	513	544	40.50	33	8.98	CHANGED	uG.spslsVSGNYAYVA..DtssGLlIVDI...SNPSSPsLpGsasT	..................s.s.ltls..G..s..YAYVA..........s..s.s.sG......Lh.IlDl......SsPssPthhuph............	0	143	204	270
+8142	PF08310	LGFP		LGFP repeat	Mistry J, Adindla S	anon	manual	Repeat	This 54 amino acid repeat is found in many hypothetical proteins. Several hypothetical proteins from C.glutamicum and C.efficiens along with PS1 protein contain this repeat region. The N-terminus region of PS1 contains an esterase domain which transfers corynomycolic acid. The C-terminus region consists of 4 tandem LGFP repeats. It is hypothesised that the PS1 proteins in Corynebacterium, when associated with the cell wall, may be anchored via the LGFP tandem repeats that may be important for maintaining cell wall integrity [Adindla et al. Comparative and Functional Genomics 2004; 5:2-16].  Deletion of Swiss:Q01377 protein results in a 10-fold increase in the cell volume of the organism and infers the corresponding proteins involvement in the cell shape formation [1]. The secondary structure of each repeat is predicted to comprise two beta-strands and one alpha-helix [Adindla et al. 2004].	20.70	20.70	20.90	20.70	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.56	0.72	-4.33	31	1397	2009-01-15 18:05:59	2005-06-23 16:04:57	6	50	220	0	484	1277	0	52.30	30	25.49	CHANGED	LGhPhu.sEtshsDG.G+appFps.GsIYWsssTGAasl.sGsIhctWtstuhEpG.	.....................LGhPss..s.E.....h.....s...h...s....s...G............u...p.hpp...F.......p......s......G......s....l...a...W..o...s...s.........o....G.....A.a.s..l...tGslhstasphuhttu...........	1	164	343	447
+8143	PF08311	Mad3_BUB1_I		Mad3/BUB1 homology region 1	Mistry J, Wood V	anon	Pfam-B_3330 (release 17.0)	Domain	Proteins containing this domain are checkpoint proteins involved in cell division.  This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p [1].	20.70	20.70	20.70	20.70	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.59	0.71	-4.35	25	450	2009-01-15 18:05:59	2005-06-24 09:15:27	7	14	255	13	294	455	1	122.00	31	13.79	CHANGED	lppp+ppaEpclpshp...tDDPLplWhcYIpWhccsaPp....ssppSsLhslLERslptFtcsc+Y+sDsRaL+lWLcYhc..hhs.....-sp-hFpaLhpptIGsplAhaY.paAphLEspspapcAsplaphGl	.....................................h..t.+ptaEtclpthp...ucDPLsha...............c..............YlpWsppsaPp...............tsppstL.hs.lLE+shptF.hsp....p..+..Y+sDsRaL+lWlcahc.hhs........................cspchap....aLhppsIGpphAhaY.paAthhEtp.sphpcAcplaphGl...............................	0	87	150	231
+8144	PF08312	cwf21		cwf21 domain	Mistry J, Wood V, Bateman A	anon	Pfam-B_14400 (release 17.0)	Domain	The cwf21 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe [1]. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding [2]. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.	21.00	21.00	21.00	21.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.27	0.72	-4.11	76	461	2009-10-29 13:58:15	2005-07-13 09:22:44	7	10	268	1	314	448	0	48.80	38	7.17	CHANGED	l-H-++...RcIElKlhEhc-cLE-..cu.....................................h.s---I-p+lsphRp+Lhpchp	............h-H-++...RclEl...Klh-hp-pLE-.....ps.................................................h..spppI..pc+VpphRpcLhpc..t.................................................................................................	0	97	155	240
+8145	PF08313	SCA7		SCA7, zinc-binding domain	Mistry J, Wood V	anon	Pfam-B_21229 (release 17.0)	Domain	This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK [1].  This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7) [1].  Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain [2].	19.80	19.80	20.00	20.20	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.56	0.72	-4.38	17	392	2009-11-18 17:56:09	2005-07-13 09:42:51	7	11	194	2	252	404	1	70.50	44	12.05	CHANGED	s++pccs+p+s.......sps+p.lDl-KQCGV.LPpGt.hCuRSLTCKoHSMGuKRAV.GRopPaDlLLs-ap++sph..K.	...............................................ttp.....................hsct.hD.s+pCGVlsscsp.t......CTRSLT.CKoHShspRRAV.GRpp.aDhLLscaptcsptp.....................	0	62	111	174
+8146	PF08314	Sec39		Secretory pathway protein Sec39	Mistry J, Wood V, Schmitt HD	anon	manual	Domain	Mnaimneh et al [1] identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes.  Kraynack et al. (2005) [2] showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006) [3].	18.50	18.50	19.20	18.60	17.70	18.30	hmmbuild  -o /dev/null HMM SEED	715	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.94	0.70	-6.60	20	278	2009-01-15 18:05:59	2005-07-13 09:48:18	6	15	208	1	202	289	0	559.60	21	47.25	CHANGED	LhLLAsplsspus..lpsLspLhspasuhls.-...lL+IlLohhP.Eoh-PpsYssllppl.psp.sts...............hhsp-shslusscshsssssp+ps..........cphcLlsL+h.tt.ps.t..ss-hlspFLhcRuhcl-p.os.hshhhpL...........Lhshhc...pssplpsWlhusllPLl+h.Nhchh..ts.sholsshpsh.sstsslslLLuhssscpt........lspsLcsllsPalhtppc.pp..hpphhtssshshhpsppp............lhcaLhspuphshtssspuh....s..p.......................ppcaspsuLuslYtss.......csohpsLshshtlhpths.lhthpt..hh.............................shlssss.lshsst.shshhptlLhohphLpphs..hshphhtphh..ps..pctQltchpshlpshhhpppstts...Wpplhpplhhlpsht................hlFsplsp-hlpscllc..sLLpsscas...lAtslhppssst................lssp.lccslhpshashassAoNss+oRsshK+Apch..Lphhssp.......hssss.shpplcsLlpAocsLSpYSL..sLppG.......PFpPlsl...Rh+sDPlulIp+lL-QNP+uYppl-cllslu+pLlpAh.......................sptpccshhsscpRl....huhsIcsALsssDFpsAYshslshLpsss..spp.............t.......c-hsWcssaQsG+YhsPs.sss...pth................LspRhElLShALplsP.s-sLpclLusWpph-pELss..Lhspcpst-sshc	....................................................................................................................................................sh.hs.psp..httl.hh.t.h..............lhs.hP.E.h.....s.tth....hl.......................................................................tt.........h....t....pt.....t....h............................t...ph.h.....t.............................p.h.pah.pRs.tlpp.st....h.t...............l..hhp...........h...th...h.......sh.hh.......h............t......h....slt.h.pph..ts.p.hhphhhp.stt......tp............hsp.hhthhhPah.....http.....................t.........t....................h...hlh.p.......p......h.......................................phht.hsLtshY.st...........p.p.h.ph..tlh.ppls....................................................................thht....s..h.p........t..hp.hpt.......hl...ssphLt.phsh..hshphhtph...........ppp.ht.plh.h.hhtph....hppts.....hs.t......Wtthhpph.hhhpp.s..................asp.ls..phh.t.hhc..uL.L.ps......s...chp...............LAtphh.p..s..s.s........................ls...pp..plVhts.hphassuos.scsphsht.+.....sp.......Lphhssp...........ss.shpc..sLl.pAhtt.L.p.pasl.............................hhPlpl..........R.......h.....pt.......D..................lslIppslppsspsYpp.ppLltlup.Lhhs............................tpp...ttp...tpl....h.h..hlc.tALtttDaphAhths.ph......ht...............................s.s.sW..cs.shphGph..s.........................................ltpR.-lLuhuLth...sP..s.....p....plt......lLs.shpphptp.h.................................................................................................................	0	59	107	161
+8147	PF08315	cwf18		cwf18 pre-mRNA splicing factor 	Mistry J, Wood V	anon	Pfam-B_19718 (release 17.0)	Family	The cwf18 family is involved in mRNA splicing.  It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe [1].	25.00	25.00	25.30	25.10	24.90	24.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.69	0.71	-3.68	31	268	2009-01-15 18:05:59	2005-07-13 09:55:05	7	3	235	0	201	257	0	132.60	35	70.43	CHANGED	usL-ttAhcRKtRLtpL+ph.................................t.ppppptttssspcssphtLphRNYcPcsc.shKtshhsssp...........ssplEcclpcQhctsctt.....cplDLhpLtP+KPsWDLKRDls+KhchLcpRTppAIAcLlR-Rl	..................................................................s.pLpttAhcRKtRLttL+ph..................................................t....ppp.p......tppspppstpp.pLphR.NYsPcsc.shKtthhsssp.............................................sspl.E.cp.lp....cphptsptt..........................cplDLhsLsP+KP...sWDLKRDlscKL-+L-+RTpcAIAcLlR-Rl......................	0	71	107	160
+8148	PF08316	Pal1		Pal1 cell morphology protein	Mistry J, Wood V	anon	manual	Family	Pal1 is a membrane associated protein that is involved in the maintenance of cylindrical cellular morphology.  It localises to sites of active growth.  Pal1 physically interacts and displays overlapping localisation with the Huntingtin-interacting-protein (Hip1)-related protein Sla2p/End4p [1].	25.00	25.00	25.90	25.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.87	0.71	-3.73	21	213	2009-09-11 00:21:46	2005-07-13 11:52:31	6	4	131	0	161	204	0	110.00	38	26.42	CHANGED	DsIDKLDVTGl.aG.GsFHHDGPFDACsPHRN+ssp..sAPVhAFPtDusNsolGG..ssssccsshspsaGpt-.-s.s...................t.sshttstsp.t..s...h..psspl...spFDsps+sE.lHGssThGLGooTFLDGAPAS+uAIpc	..................DhID+LDsTul.a.G..GhFHHDGPFDAssPcRN+psp......tAPl.tAF.....st...D.u.Npsltu........s..p..tht..hu..t...................................................................ss..p...h.u..o.GLssoThl-GsPAs......t......................................................................................................................	0	34	81	130
+8149	PF08317	Spc7		Spc7 kinetochore protein	Mistry J, Wood V	anon	manual	Domain	This domain is found in cell division proteins which are required for kinetochore-spindle association [1].	34.00	34.00	34.00	34.30	33.70	33.30	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.95	0.70	-5.77	15	147	2009-09-13 12:07:19	2005-07-13 15:40:18	6	13	141	0	113	154	0	314.20	25	26.55	CHANGED	l-...........psspschEPIpLp-FLshssI+F.....hplsohcRhpsohss...............pspssshcDhlsAtasslPhLELYp..aSC+EL++hIuEGRcll+plEscThs-NPP.LF+EYhoAss-h+lLMcsQhp.VKoaARLpSKssWYEWRhpLLcGLK-sLtcplpthppDcchLs+p.shlsslhsclpc+psuLccEhssLcplsc-.....hspsDpp-Lpsh+pcLpplcpcIstpppplpELpsclpchsssIpsssppKpphhtcIp-t-+lhccs+saospEIscL+pphptlcphoGaslhuls.......Gsslohsaccp..........lcLsFs.......usapl	..............................................................................................t.tttt.......t.php..lp..Lp-FLshsslcF......hph.....sss+Rppshhst........................ttpshslcchlsA..thhslPhLELYp..auC+ELpphIs..-G+ph..hcplEscs..htpN..PP.LFpE.Y..hs.....u.s..........s-.h....+..h.l....McsQhp.lKsauRL.uKthWYEWR..hpLl..cGLcpsLtcphpthppDtphLs.cptphls.sllsplhpcpptLppEhp.pLpph.spE...........hpssDp..p-Lpph+....pcLtphctc...........lpthppplpchppclpphppp.l..cphspp+pphhppIp...cs-+hh-.cs.+sa.otpElppL+splctLEp.pGhplhphp................u.s.tl.phtappp..........lpl.ht............t............................................	0	40	67	98
+8150	PF08318	COG4	Sec38; 	COG4 transport protein	Mistry J, Wood V	anon	manual	Domain	This region is found in yeast oligomeric golgi complex component 4 which is involved in ER to Golgi an intra Golgi transport [1].	20.10	20.10	21.10	20.90	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.82	0.70	-5.67	14	351	2012-10-02 15:56:29	2005-07-13 15:46:43	7	11	268	0	250	355	4	282.30	26	39.00	CHANGED	LcphpcpLpplFpccFpcAs+spDltplT+aFKLFPLlGtc-hGLshYucYlCphIAscuRphhpss.t.......sptshhaupslhpLF-plupllpsHstllpphYG..sst...hlpllp+lQcEsDhQsulll-pFhDpR+lcchhppIspas...hst.............t........stp.phlsh+-lssllsEhotlhppWslYp+Fhsh+h.p..............hsssp.p.....hphspllpsuphsppl..pcllssFhtLppaahpcSlp+ulpl-ch...............ptps..sSShV-Dlhhll+psLtpslsTuphsslsphlsp.lsphlpsDa.hphhpspl+	.....................................................................................................................................................................................................................lppspppLpslhhccFtpAspp.....tDhsplpRFFKlFPll..G..h..pc.GLpha............upYlsp.ls.tpuc.t........hp.s.ht...........................pp....tshh...aussLohLF-tlupll-sHtsllc..ph.YG.....sp...................hhp.llptLQhEsDhpsth.llcpa.cpR.ph..pphhp.plpp..ht..st.........................................................................-.t...l...s..+.-lD.lLsEhshh.tphphYh+Fltp+htt...................................................................t.pt..............phsphlppst.hspph..pclls.....Y.shppaahccolpKAhtl.Dph.....................................................................................tps.hhoS.hV.DDlhallppsltRuluouphsslsuhlst.hsphL..ps-a.hthlppch...................................................	0	91	145	210
+8152	PF08320	PIG-X		PIG-X / PBN1	Mistry J, Wood V	anon	manual	Domain	Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I [1].  These enzymes are involved in the transfer of sugar molecules.	20.50	20.50	21.30	21.10	19.80	18.60	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.57	0.70	-5.05	22	258	2009-01-15 18:05:59	2005-07-13 15:56:35	7	5	217	0	165	278	0	194.10	24	54.09	CHANGED	pPsGLHPpLplslss.............spssppCplahahpLPpslFhD+YQ.........t..shs.plhhltGtsDLEhP-Yth..ppWGSphLhcltss............................hpsplPLHhRYhcPup..ssh....pslsls.PhlFhuCssc-ss..........htpsPFsph.....shua-shFsscThFaals.p..................ptslplplPhsst.......tshptVphsThlsllluhla....llhplhtt	...............................sGhH..sL.lp.lph..................h.st.ppCpl.hhh...pLPs....slFsD.apLts.......................................Lppcshh...phh.....hltsps...DLEtP..sa........pp.hus.pl.Llplp.ss................................t...pphpsplPlHhRY...hpP....ps...tsuh..............ppltls.Ptl.hhtC.stppst....................ht..sapph..............sh.s.hhtsp..shh.ahp.t.......................hs.tlplPlhph..........phthlp.sThhhhhls.hhlhhtl...h...........................................................	1	43	84	133
+8153	PF08321	PPP5	PPT1; 	PPP5 TPR repeat region	Mistry J, Wood V	anon	Pfam-B_6912 (release 17.0)	Family	This region is specific to the PPP5 subfamily of serine/threonine phosphatases and contains TPR repeats.	23.50	23.50	23.60	23.80	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.16	0.72	-3.97	10	434	2012-10-11 20:01:00	2005-07-13 16:27:50	7	49	269	28	266	410	3	88.60	30	17.10	CHANGED	KlpECcKlV+clsFEcAIul.-cpc+Sls-sl.DlEshsIEs-YsGP+LEsspVTl-FlKchhEaaK.pQK+LH++aAYpILlplcclL+ppPSLV-l	.............................................h..spphlpp.tF.tAIt..............o.h.....h-..th....D.h...-.s..h.........s....l.-c.s...Y.sGP+................L..............p.....................t...............p...............lTh...............p.............Fhcphl.-t.FK..ppK..pLH.++YshpILhps+cllpp.Pohlc.........................	0	82	129	200
+8155	PF08323	Glyco_transf_5		Starch synthase catalytic domain	Bateman A	anon	Pfam-B_148 (Release 17.0)	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.98	0.70	-4.88	179	5560	2012-10-03 16:42:30	2005-08-09 17:08:06	6	34	3850	19	1001	5688	791	204.20	33	44.27	CHANGED	+...lLaluuEs..........sPh..sKoGGLuDVssuLPpAL..tphG.t..-V..cllhPtY.stl.pph.........php.lhp...h............h..........h.hhph.h...........p.slslah.l-s.t.....ha.p....Rss..hY............sa.DsspRFu...hFupAshchhtt.h..........sh.t..PDll..HspDWpTuLl.PhhL+ph.htt.......stoVhTIHN.........lsaQGhas...tphh.th..hsls..........h...pthcahs...........................plshlK.uGlhhuDtloTVSPoYAcEItsst.......hG..GL-slLpp	........................................................................................................................................lh.hs.Eh.............sh......p.GGL.ucsht.u.Ls...t...........t........s..h..c.s....hh..l..h.P....ha....h.t.t.................................h..................................................hth.h.pthh...................................p..Glsh.hh...l...D.....p.h....................ah..p.....................+ss...........hYss....................sah.D.s.t.h..R.Fu...............hh.sp.A..u.l.Ehsph..l........................................sa..t....Dll..h.spD.WH......ou.Ll.Ps..a...L.+th...h.......p................h..............t......s+..........sshsIHN..............lsaQG..hFs..........hp.h...sh....hsLs.............phh........t...s.h...c...a......s.............................pl.sa.h...K...AGl.h..uD+lsT...VSP...hYApElhss.........th.tL-sllp.....................................................................................................	0	340	651	848
+8156	PF08324	PUL		PUL domain	Bateman A	anon	L. Iyer	Domain	The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain.  It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates [2][3].	21.00	21.00	21.40	21.50	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.74	0.70	-5.60	22	406	2009-01-15 18:05:59	2005-08-10 13:17:14	6	21	274	9	297	411	2	256.60	19	36.81	CHANGED	phhPhpphlhhcshshctlhp+lpchNsp.......tchphs-pplss....ltphlpthpps.t........hpthhthhhpllpsWs.sphhPslDllRlhlhp.sss.hh..t.........ss.hsphhtts.ss...................tp.s.hhhslRhlsNhFsssshtthlhspts.........plhstlsshhssh...............spNlplAlATLhhNhulhhhcss.........sh-hph.lluslhp.....htc..pspEAhYRhllAhGsLh....oht.sshtthspt.........shsthhptptp.........hsp.t+hp-lsp-l	..............................................................................hhP.pphl.hh..cp.s.s.h.ptlhpKl.t.chNtt............tphth...sp..splpt.......ltphl.p.......thpps.ss.....................hpt.h.h...hl.hp.hhtpW.P......s..h..h.hPslDll.Rl.hlh.psp....s.ss..h.hspt..................tphhtphhp.t..s....p...................ss.stthl.slRhhsN.hF.......s..s....tthp.......phhhsptp...............tl.hstltt.htss..............................spNlplAhuTLhhNhulhhpppp........................stctphtll..uslhp..................lhpt..tp.s......Euha.RhLlAlGsLl..........sss.sphhphsps........hth.t.thh.tthtp...................hsp..hhtphht..........................................................................	0	103	168	244
+8157	PF08325	WLM		WLM domain	L Iyer, Bateman A	anon	L Iyer	Domain	This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases).  These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.38	0.71	-4.42	23	403	2012-10-03 04:41:15	2005-08-10 14:50:09	5	13	219	0	290	2217	499	191.90	27	49.79	CHANGED	spstphphLp....pt.PscscALchLp+lAsp..lpslM+c++a+VshLsEhhPppts..................LLGhNhN+Gpc..................IpLRLRsss..ppFlsacslhsThLHELsHslausHDppFacLhcpLps-htplphth.......thhssG+pluupshh.s...............tth.httsthtGtsppLG.Gss...................................................................................................................ssstshRchhutAA-+Rhp	.......................................................................................................................................................l......hPp.tppAhphLc+lAst..lpslM+.c+.papVshLsEh.Pp.pts.......................................lLGhN.....h....N.pGpp............................I..pLR..L.Rsss.......pta.h...shc....p..lhp.T.h.lHEL...sH.......s..l..aus..Hsp.pFa....sLhs.p.L..p..c..Ehp..pl..t..h..p..................h..stG.ppLustth.......................................t..ttthhts..ts...hLG...Gss..............................................................................................................................................................................................tshshRphhAtAA.pRh..........................................................................................................................................................................................	1	97	176	251
+8158	PF08326	ACC_central		Acetyl-CoA carboxylase, central region	Fenech M	anon	Pfam-B_2008 (release 18.0)	Family	The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (Pfam:PF01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyses the rate-limiting step in this process.	18.50	18.50	18.60	18.60	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	708	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-13.13	0.70	-6.42	37	703	2009-01-15 18:05:59	2005-08-10 14:56:40	7	35	365	6	377	673	13	529.70	28	30.19	CHANGED	sLDDPS+V++....ApPFpGpL..PchusPshh.G....sKstp+apthhss...............LpsILsGY.......phhhss.slppLlpsLcsscLPa.paptphSsLtsRlP.pLcptlpphhcchptp....tsp........FPu+pLppllpphhs...hss.....hhthsltPLhplhppYpsGlpsHthslhtsLlccYhsVEplFs..sspp--VIhcLR-cpcsDlpcVlphlLSHuplssKNpLlLulL-ph.ps..................sssthcssLp+lspLps+stu+VAL+ARElLlpspLPSlcpRpsplcclLpu..shhpsthGp.......h.p+ptsph-hlc-LlsSphsV..hDlL.spFF..scsDthVphAAlEVYlRRu.....YpuYp.ltc....lpacpps......slhpWcF..lsp.t.sphst..........................................p..chtshoshohhspptpt......RtGhhlshcpL-clpphl.stuLcthsp.......................tt...t............t.p.....sp.sNlhslsl.........pphpsh..s-p-llsclptllcppc..pcLts.tulRRlTFlhsp.pc...............uphPpaaTF+..uss.......YpE-phlRHlEPuLAapLELsR..Lp.sFclp.l.opsRplHlYpus..........................uKp.........sssD+RaFhRullRsupl..psphsht-hL.uEss..............Rlhs-hLDsLElhsss....poDhNHIFlNhss.hpl....................sspplEtuhsshlcRaGpRLaRLRVspsElRlhls....sssssshPlRsllsNsSGaslps-lYtEhcssp.u............phla+Shs...c.Gs.hH	..............................................................tLDsPotVpt.....sp.a.u..h.......P...t.......h..s..............tp..phht..hp..........................h...lhtGa....................................t.....hpt.hlpphh.sLc...sspLPh.phpt.hssltsRhP..lpt.hpt.ht..t...................................................................................FPup.l.thhpt.ht................................htslhplhp.pattG.t.......h.......h.hh.tlhppYhpVE..p.Fp..................p...ppsl.tl.Rpp..p....s.httVhphhhSHttlttKs.Llhhlhcth............................................................st.hhs.L.ch.spLp..p.pt.......s...cl...uLcApp...........l.L.tsthsphc....spht......p.h....p...h......t..................................................p..hpcll.u.hsl...D.......h.L...hF....pts.....hlt.t.shEs..YlRRh.....Y.sa..ltt......hpht...................hh.apF.....t.................................................................................................................................................................+hGhhh..hp.hpth..........t......h.sthht.h............................................................................................................................................................tp..thhplsl................................t...pt.....ptp....thht.htthhpp.p..t.Lht.ttl+clohhhtp...p.....................tthPtaaTF+.h.s......................................atE-phhRclEPsluhpLELsR..hp..pa...plp.h..st.s...c...phHlY.uh..........................................................................................u+............tshDhRhF....hRullR...p.sph..............hsc..sshphh.sEsp................................Rhl.phh-tL..E.l.h......p.........p..........................p....s.ch....NHlalsh....h.....s.....h.h...........................................sstplcp.htthh.phG.Rhh+LpVhthEl+h.hp..........s.ss.s.hshRlhlsN.oGahh...phphYhEhps.p..t.......p.hhapuhs.......u.................................................................................	0	139	213	317
+8159	PF08327	AHSA1		Activator of Hsp90 ATPase homolog 1-like protein	Fenech M	anon	Pfam-B_4145 (release 18.0)	Family	This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38, Swiss:O95433). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity [1]. It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress [2]. p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport [3]. It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family (Swiss:Q8XY04 and Swiss:Q6MH87).	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.83	0.71	-4.02	114	4271	2012-10-02 19:24:03	2005-08-10 15:01:15	6	39	1661	63	1665	4537	461	127.90	18	71.07	CHANGED	ssss-pVacuhTcs-tltp.W............hs.hph-h...+s..GG.paph.........tst.hstpsp...........hhcltssc+lshs.atht..t..........................httlshplpp.tsss..Tclphpp..........sshstspttp.............hptGWpphl.cpLpphlp	........................................................ss.cpVacs...hos.schl....tp...W......................h.t...tph.-h.............cs......G.G....pa.ph................t...tst..t.h.s.h..p.sp...................hhcl..p.s..s.........c..........p....lshs..htht......t...................................................ts.tlp.hp...h..p...p.....p.......s.ss.......Tplp.hpp....................sshst...ppttt.................httGW.pthl..spLpthl.................................................................	0	625	1111	1404
+8160	PF08328	ASL_C		Adenylosuccinate lyase C-terminal	Wuster A	anon	Pfam-B_1176 (release 18.0)	Family	This domain is found at the C-terminus of adenylosuccinate lyase(ASL; PurB in E. coli). It has been identified in bacteria, eukaryotes and archaea and is found together with the lyase domain Pfam:PF00206.  ASL catalyses the cleavage of succinylaminoimidazole carboxamide ribotide to aminoimidazole carboxamide ribotide and fumarate and the cleavage of adenylosuccinate to adenylate and fumarate [1].	34.10	34.10	34.10	34.50	31.90	32.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.38	0.71	-4.24	107	1767	2009-01-15 18:05:59	2005-08-10 15:17:40	6	8	1709	11	421	1259	659	115.00	62	25.35	CHANGED	SRaQRDLTDSTVLRNlGVuhGaollAYpuhl+GLsKLplNpsplspDL-ssWEVLAEsIQTVMR......RaGltpPYEpLKcLTR..Gp.plstcslppFI..csLc.lP-psKscLhtlTPssYl	.......SRWQ.....RDLTDSTVLRNLGVGlGYuLIAYpSoLKGluKLElNcs+Lhc-LDpNW.E.VLAEPIQTV....MR......RYGIE+PYEKLKELT.R...GK..clssEuh+pFI-u...Ls...lP--.....t..KsRL+uhTPAsYI........................	0	122	261	354
+8161	PF08329	ChitinaseA_N		Chitinase A, N-terminal domain	Fenech M	anon	Pfam-B_1049 (release 18.0)	Domain	This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [1,2]. It is separated by a hinge region from the catalytic domain (Pfam:PF00704); this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution [1].	21.20	21.20	21.20	21.30	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.58	0.71	-4.38	43	378	2012-10-03 16:25:20	2005-08-10 15:19:53	5	25	265	36	56	351	4	122.60	40	18.18	CHANGED	sAsPGsPoIc......Wu-.psaul.....Vclsp..pAT.uYppLVph.c-tlsVsVoWNlWSG-sG-puplhhDGpp......Va....pGsus..sppA..shplspGGpapMpVcLCNu-G....CSsSs.ssplllADTDGSHLtP.L.h..shpENN+saspps	....................................t.PshPsls...aup...pphth..lpls...tsT..uYpphVph.+-tssloVsaNhWo..Gs.sGsoh+lhhsGpp......Vh.......oGsss....upsoA.....sFph..s..KGGpYQhplcLCNusG....Cop.Ss.sscI.slADTDGSHLtP.Lph..slt.NNKsap...s..................	0	13	26	38
+8163	PF08331	DUF1730		Domain of unknown function (DUF1730)	Wuster A	anon	Pfam-B_1023 (release 18.0)	Family	This domain of unknown function occurs in Iron-sulfur cluster-binding proteins together with the 4Fe-4S binding domain (Pfam:PF00037).	21.40	21.40	21.50	22.20	20.50	21.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.50	0.72	-4.31	57	2383	2009-09-10 21:15:36	2005-08-10 15:23:48	5	19	2359	0	510	1721	810	77.80	37	21.12	CHANGED	RscPptLlPss+SlIuluhsYhs.......tshpssppuhlo+Yuh.G+DYHcll+c+LcpLuphlppps.sch..t.....h+shVDo	............................RscPctLlPustslIulths....Yhs...................t....s.............................p............s..l..............p...s.....scp.....GhlSRYAh....G.....+..DYHcllRpRLccLuc......h......I......p....p....cs....s.sh......p..............h+sFVDo...........................	1	151	311	421
+8164	PF08332	CaMKII_AD		Calcium/calmodulin dependent protein kinase II Association	Wuster A	anon	Pfam-B_1025 (release 18.0)	Family	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII).  These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1].  The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.49	0.71	-4.24	7	782	2012-10-03 02:27:24	2005-08-10 15:27:36	5	6	295	44	244	1086	152	118.40	52	32.17	CHANGED	ccpEIlplT-pLlcAIssGDacsYo+lCcsshTsFEPEAhupLl-Gh-FH+FYFE.hhupps+slppslLsP+V+llGD-uAshAYl+LhQhhDcsGhs+ohQupETRVWp++sG+WpsVHhHRSuus	....................................................................................RKQEIIKlTEQ.L.IE.A....ls.sG...D...FE...uYsKl..C..D..P..s..h.TuFE...P.EA......LG.......N.L.V.E.G.h.DFH.......+...F....YFE...N.h..L.u.....K..s.......s..K.s....l.....+.T.....hI..L..N..PHV....H..l.l..G-.-..u..A...C.I.A...Y..l.....R..l..T.Q..a..hD.u...........p..G.hs..+.o.sQ.S..EETR.VWH....R....R....D......G.....K.....W..VHaHpSusP......................................................	0	55	91	151
+8165	PF08333	DUF1725		Protein of unknown function (DUF1725)	Fenech M	anon	Pfam-B_2110 (release 18.0)	Family	This family include many eukaryotic and one bacterial sequence. Many of its members are annotated as being putative L1 retrotransposons or LINE-1 reverse transcriptase homologs. The region in question is found repeated in some family members.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	20	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.32	0.73	-6.56	0.73	-4.47	24	244	2009-01-15 18:05:59	2005-08-11 08:45:36	6	30	26	0	135	164	33	19.60	62	2.50	CHANGED	hpFhGKWMELEsIILSElsp	......FsssWM-LEsIhLSEloQ.....	0	2	8	20
+8166	PF08334	T2SG	GSPII_G;	Type II secretion system (T2SS), protein G	Fenech M, Desvaux M	anon	Pfam-B_1144 (release 18.0)	Family	The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria [1,2]. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme [3]. Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet [1].	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.56	0.72	-4.30	175	1599	2012-10-03 10:38:27	2005-08-11 08:56:08	6	8	1122	10	474	1149	368	105.00	40	69.58	CHANGED	plhs.......ph-....cA...+hpsAcsplpslps.AL-hY+L.DsGpYPospp.GLpALlptPsst...ppa.pGsYl..cplP.pDPWGps...YhYh..sPG....t..p.G.thDlhShGsDGp.GGpu.suDIssW	................plhuph-+ActppAh.sDI..s.s...Lcs.AL-hY...........+............L....D..........N..G.c...............Y.P..o....s.p......Q...GL.c.A.Ll..ppPss................spsa..ps...uYl....++L.P..pDPW..Gss............YpYl....sPG............p.....c.....G.thDlaS.hGsDGp..GG-s.stDIssW.................................................................	0	154	301	395
+8167	PF08335	GlnD_UR_UTase		GlnD PII-uridylyltransferase	Fenech M	anon	Pfam-B_2147 (release 18.0)	Family	This is a family of bifunctional uridylyl-removing enzymes/uridylyltransferases (UR/UTases, GlnD) that are responsible for the modification (EC:2.7.7.59) of the regulatory protein P-II, or GlnB (e.g. Swiss:P05826, Pfam:PF00543). In response to nitrogen limitation, these transferases (e.g. Swiss:P27249) catalyse the uridylylation of the PII protein, which in turn stimulates deadenylylation of glutamine synthetase (GlnA). Deadenylylated glutamine synthetase is the more active form of the enzyme [1]. Moreover, uridylylated PII can act together with NtrB and NtrC to increase transcription of genes in the sigma54 regulon, which include glnA and other nitrogen-level controlled genes [2]. It has also been suggested that the product of the glnD gene is involved in other physiological functions such as control of iron metabolism in certain species [2]. The region described in this family is found in many of its members to be C-terminal to a nucleotidyltransferase domain (Pfam:PF01909), and N-terminal to an HD domain (Pfam:PF01966) and two ACT domains (Pfam:PF01842) [3].	20.50	20.50	20.50	20.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.78	0.71	-4.35	122	5858	2012-10-01 22:14:54	2005-08-11 08:58:32	6	24	2142	3	1374	4628	1176	134.10	23	21.87	CHANGED	chhctplpcp........tpR+..........tphs..........t.NlK.G.GGlRDlchlh.ltphhh.............thpsLptLhpt.....uhlspp..-hppLpcuhpFLhplcptL.phlss+pscpLs..h-......tptplAph.h....G.................a.............sshtu...ahpphhpttppVpphhphlh	..............................................................hptpl.ppp.................ht.c+...............tt.p................slKhutGGlRDIEalsQ..lh..p..Lhautp..tl.........p..sslpsL.ptls..ph.......uhl..s..pp...-s.tpLp...cuap...hL..pc...l..c...p..t..L...ph....h..t...s....c....t..s....p..t.L....s.......................t..tl..A.h.h...s....................................h.....................ts..t.....hhpth.hthhppltth.p.h..................................................................	0	366	832	1128
+8168	PF08336	P4Ha_N		Prolyl 4-Hydroxylase alpha-subunit, N-terminal region	Fenech M	anon	Pfam-B_2013 (release 18.0)	Family	The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyses the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase [1-4]. The function of the N-terminal region featured in this family does not seem to be known.	22.70	22.70	22.80	23.90	22.30	22.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.56	0.71	-4.34	57	702	2009-09-11 11:25:59	2005-08-11 09:00:04	6	15	93	0	369	644	0	123.70	30	26.34	CHANGED	oSlsphpcLlphEcpLlssLcpYlpt.pp+lcpl+phhpphcppppputp..chppYlusPlNuFtLl+RhppDW.pl..cphhpps.hspp..hlptlpphtp....ph.Popc..DlpsAspulhRLQssYpLpspclApGh.lsGh	................oShsphpcLlthEppL.lpsLcpYlpt.pp+lppl+.......ph...hp.....phct...........pp..putp...s.ctal....upPlNAapLl+RLpsDW.pl..cphhtps....spt.......hlss.lp..pp......hh.Ps..p-..DhpuAupuLhRLQcsYpLcspslupG.l.G.........................	0	106	122	259
+8169	PF08337	Plexin_cytopl		Plexin cytoplasmic RasGAP domain	Fenech M	anon	Pfam-B_3123 (release 18.0)	Domain	This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytoplasmic region, which has been called a SEX domain in some members of this family [3], is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [4]. This domain acts as a RasGAP domain [5].	20.10	20.10	20.10	20.60	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.65	0.70	-6.19	11	880	2009-01-15 18:05:59	2005-08-11 09:05:10	7	64	115	19	421	669	1	437.30	47	33.18	CHANGED	uGIPFLDY+sYshRlFF...........................sGpcsHPlhtchp....ttppsslEpuLshFusLLNsKsFLlsFIHTLEpQ+sFShRDRsplASLLhlALpuKLEYhT-Il+sLLsDLI-ps..sK.pPKLMLRRTESVVEKMLTNWMSlCLYsaL+EssGEPLahLapAIKpQl-KGPVDAlTGcARYTLNE-+LLR-slEa+slsLp..........sl..htscss-u........lsV+VLsCDTIoQVKEKlL-slY..KssPaSQRPcsc-lDLEWRsGptu+llLpD.-DlTohhEst.WK+LNTLtHYpVsDGAoluLssp....sshp.s....................hssssssstpttsh.sc..ps................+haHLV+PpD-.s-.....pp+ucRts...............+sKslsEIYLTRLLoTKGTLQKFVDDLFpoILSh..hspslPlAlKYhFDFLDEQA-p+GIoDPDslHhWKoNSLPLRFWVNllKNPQFVFDIcKosphDACLSVIAQTFMDuCShSEa+LGKDSPoNKLLYAKDIPpYKchVccYY+cIpphsslS-QEMNuhLAE.S+tHss-FsshsALpELYpYlpKYtppI	..........................................................................................................................sIPaLDY+sYs.RlhF..................................................s...u.h.psp..l.h.tchc............t.tt.ph..-puLt.hupLlssK.....hFLlpF..I+TLEtQ.+...sFShRD..R.s..lASLlhh..sL..p..u+hEYhTslh+pLL.-Lh-p...sK..pPKL..hLR.R..T...EoV.sEKhLoNWhohh.....Lap..aL+..................-s.........sGEPLahLapAIKpQh-KGPlDulTscA+YoLs-stLl+p.pl.-apsl.s.lp.............................sl.......ts...t.s...t.................ls.V+l.LsCDTIoQlKEKlL-tla..+shPhSpp.Pp.s.ts...h....-L...............EW..RtG......t.h.......s...p.....hlLpD....D.......h.T........o.h.......h.pst...WK+L...NTL......tHY..p...V..s-...u...u.s.lsLs.p........p...............................................................................h.t.tp.p......t..p.p....t....s.h....p.......pt.......................+haH.LV+s.p..-c....c..........thcscR........................tsKhl.sEIYLTRLL..u.....sK.G.TLQpFVDDhFpslhS.........s.p..s..lPhAlKYhFDFLDE.QApp...+..t.I.p.D.......-shHh.WKo..N..sLPLRF....WVN.llKNPpFlF.Dlc..psshsDAsLSVlAQTFMDuCoho-H+..LG.............+...............DSPoNKLLYAK-IP.pYKp........h...V-..cYYtsItphs.slS-Q-MsshLsE...S.......+....a..ts.ph........ss.sALpElY.p.Y.hpKYh-pl........................................	0	104	131	262
+8170	PF08338	DUF1731		Domain of unknown function (DUF1731)	Wuster A	anon	Pfam-B_1045 (release 18.0)	Family	This domain of unknown function appears towards the C-terminus of proteins of the NAD dependent epimerase/dehydratase family (Pfam:PF01370) in bacteria, eukaryotes and archaea.  Many of the proteins in which it is found are involved in cell-division inhibition.	20.40	20.40	20.40	20.90	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.09	0.72	-4.47	150	2466	2009-01-15 18:05:59	2005-08-11 09:12:23	6	12	2252	1	619	1759	633	48.10	39	15.43	CHANGED	lP..uhsL+...lllG.Ehu.pllLpuQ+VhPp+LhpsGFpFcassLcpALpsll	..............lPuhsl+....llhG..Ehu.tLlLsGQ+slPp+L.p.p.s.GFpF+assLcpALpsl...........	0	205	395	534
+8171	PF08339	RTX_C		RTX C-terminal domain	Fenech M	anon	Pfam-B_2178 (release 18.0)	Family	This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli (Swiss:P09983) and Actinobacillus pleuropneumoniae (Swiss:P15377). RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes [1]. This region is found in association with the RTX N-terminal domain (Pfam:PF02382) and multiple hemolysin-type calcium-binding repeats (Pfam:PF00353).	30.20	30.20	30.20	30.70	30.10	29.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-11.04	0.71	-4.48	11	230	2009-01-15 18:05:59	2005-08-11 09:14:43	5	17	136	0	4	184	0	136.40	36	15.23	CHANGED	shSDhshcDlsFc+VscsLll...........pNs+psplTIpsWFccushup............pscKIEpIlsKsGc+ITScpl-cllp.cscGp.IptpsLsp...................hu-sath......t.ptsslsNslsKlISSsuuFsoup....sptsuhh..lsosths...phpohpLApAA	........phSDlshcDlsFcRlssDLlh...........psscts.s.lThpNWFtcss.ut...................................ps+pIEpIhsKsGccIss-pls+hhp.ptss..htsptlup......................pp..s........shsslsNslsKlISSsuuFsos.....spthush..ls.pt.ss....ppuhpLsps...............................	0	0	0	4
+8172	PF08340	DUF1732		Domain of unknown function (DUF1732)	Wuster A, Eberhardt R	anon	Pfam-B_1065 (release 18.0)	Family	This domain of unknown function is often found at the C-terminus of bacterial proteins, many of which are hypothetical, including proteins of the YicC family which have Pfam:PF03755 at the N-terminus. These include a protein important in the stationary phase of growth, and required for growth at high temperature [1]. Structural modelling suggests this domain may bind nucleic acids [2].	20.50	20.50	20.70	21.50	20.20	19.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.88	0.72	-4.16	157	2499	2009-01-15 18:05:59	2005-08-11 09:16:42	6	3	2472	0	580	1771	606	85.80	52	29.77	CHANGED	tQElslhApKsDlsEElsRLpoHlsphcchL.p...s...........s...............s.lGR+LDFLhQEhNREsNTluSKus.....shplophsl-lKs.lEphREQlQNlE	......QElslhAp+hDlsEELsRLcuHlpphpplL.cp...p........t........................slGR+LDFlhQEhNREuNTluSKS.......ss-lostul-LKslIEQhREQlQNIE..........	1	207	385	489
+8173	PF08341	Fb_signal		Fibronectin-binding protein signal sequence	Wuster A	anon	Pfam-B_4004 (release 18.0)	Family	This domain is found near the N-terminus of fibronectin-binding proteins in Streptococcus where it functions as a signal sequence [1].	25.00	25.00	25.50	26.00	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.95	0.72	-3.97	30	227	2009-01-15 18:05:59	2005-08-11 09:19:11	6	21	39	6	11	210	0	74.20	35	16.57	CHANGED	PaYGY-uhss.h........tYHcLcVs.LpGo.+pYp..VYCFNlc+p.P.cspuhspsa.............Yc+l-Gss.psFppYAtsPR	................saYGYDshssh...........pYHcLpVs...lpGo..csYQ.....VYCFNls+phPpsspu.hspsh.............YKKlcGos.psFppYAtsPR.....	0	0	2	8
+8175	PF08343	RNR_N		Ribonucleotide reductase N-terminal	Wuster A	anon	Pfam-B_1066 (release 18.0)	Family	This domain is found at the N-terminus of bacterial ribonucleoside-diphosphate reductases (ribonucleotide reductases, RNRs) which catalyse the formation of deoxyribonucleotides [1]. It occurs together with the RNR all-alpha domain (Pfam:PF00317) and the RNR barrel domain (Pfam:PF02867).	20.80	20.80	20.80	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.75	0.72	-4.17	65	2010	2009-01-15 18:05:59	2005-08-11 09:27:31	5	10	1914	6	245	1190	16	80.30	42	11.63	CHANGED	YhpLNspl.Nl.spsGplp.hcKD+EAlcsahpppVpsNThhFsSlcE+lcYLlcp.sYYEpphl.cpY...shsalccLachAaupcF	..............YatLNs.l.NhhsssGpIp.h-KD+EAlcuahtppVps..NTl..hFsShpE+lsYLlcc.sYY-pshl........scY.......shsFlpcLapaAcspsF...........	0	53	132	191
+8176	PF08344	TRP_2		Transient receptor ion channel II	Wuster A	anon	Pfam-B_1032 (release 18.0)	Family	This domain is found in the transient receptor ion channel (Trp) family of proteins.  There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors [1].  This domain does not tend to appear with the TRP domain (Pfam:PF06011) but is often found to the C-terminus of Ankyrin repeats (Pfam:PF00023).	20.90	20.90	20.90	24.10	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.07	0.72	-4.04	18	680	2009-01-15 18:05:59	2005-08-11 09:37:35	6	28	108	0	347	603	0	62.10	55	7.46	CHANGED	CsCs-C.ptpppDSL+HSpSRINsYRALASPuhluLo...ScDPlLoAFcLSaEL+cLuthEpEF+	................CpCs-.Cspp.pct.DSlpHSRS.RlNsY+uLASPuhluLS..............SEDPlLTAFcLStELpcLu....plEpEFK.............	0	97	125	217
+8177	PF08345	YscJ_FliF_C		Flagellar M-ring protein C-terminal	Wuster A	anon	Pfam-B_1149 (release 18.0)	Family	This domain is found in bacterial flagellar M-ring (FliF) proteins together with the YscJ/FliF domain (Pfam:PF01514).	19.20	19.20	19.30	19.30	19.10	17.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.08	0.71	-4.27	169	2282	2009-09-10 21:18:48	2005-08-11 09:40:36	6	5	2017	0	541	1738	450	168.80	31	31.19	CHANGED	LpsllG..s..ssp.spVss-lDFsptppspcpa........cP...sp...........tsl.RSpps.pEss..ssst...sss..G...lPGshoN...h..Pss...........................sssts..sss...................................................t..................sscpcps....pNYEls+shppspp.ssGplc..RLSVAVll.st..........t....................t..thtshssp...clsplpsLVpsAlGas.....ts..................RGDs.......l.sVsshsF	.................................................LsPllG.ss.ph+.spVsspl.DFspp-popEpY........sP.....st.............ssl.RScQp.p-sp....pust.....hssG......lP.GuhS.Np.....Pss.......................s......tts...........................................sp.............ssc..pppTpNYEl..s+ol.pcscp..ssG.s..lp..RLSV.AVl.V..st..................................p...................psp.hsh.osc...phpp....l..csLlpsAh...Gas.......tp.......................RGDs.......l.sVsshsF..............................................................	1	175	342	438
+8178	PF08346	AntA		AntA/AntB antirepressor	Wuster A	anon	Pfam-B_2097 (release 18.0)	Family	In E. coli the two proteins AntA and AntB have 62% amino acid identities near their N termini. AntA appears to be encoded by a truncated and divergent copy of AntB.  The two proteins are homologous to putative antirepressors found in numerous bacteriophages, such as the hypothetical antirepressor protein encoded by the gene LO142 of the bacteriophage 933W [1].	20.50	20.50	20.60	21.10	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.65	0.72	-3.78	57	810	2009-01-15 18:05:59	2005-08-11 09:43:36	7	14	597	0	102	564	4	70.80	41	31.26	CHANGED	VsAR-LHphLcl.ppcFssWhctRhpcYs.FhEs.DFhsh.p.....................tpspuu+............phDYtlTLDhAKEluMlpRs	..............lsAR-LHphL......pV..ppcFssWhc.Rh..p...cYG.F.tEstDah..shpp..........................ht.s.tts..us+...........ptpDYtLTLDhAKElAMlpRs......................................................................	0	22	65	79
+8179	PF08347	CTNNB1_binding		N-terminal CTNNB1 binding	Wuster A	anon	Pfam-B_2064 (release 18.0)	Family	This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (Pfam:PF00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation [3].  Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation [1,2].	22.40	22.40	22.40	22.80	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.81	0.71	-4.06	18	496	2009-01-15 18:05:59	2005-08-11 09:47:26	6	5	89	10	161	406	0	168.80	45	42.31	CHANGED	MPQLs.....uuGGD.DLGAsDEhlsFKDEG-.p-EKh...sENs.s.tD....Ls-lKSSLVsEoEsspssss................cth......................pRpsps.h....sa.-c.tc+h-p.s+ppp..shGhh.+s.sYs........uas.hhhh......sps..sNGohuP......................................uNKlsVlpss.th.s..LsPLhs...Yss-Hao.GsPP....shhPs-l.ssKs....Gls.RPspss-lsshYPLssuthGQls...asl.sW	.......................................................................................stsuD.-LsusDEhh.FpDE..Gt.pp-......tt..........L.s-.KSSLls.oE...ts.........................................................tct..s............a...t...p.....tt..tt......s..uhh..+sssYs........uas..hhM.............t.shh...ssuu.SPs.............................................................................................................SNKVPVVQ.sHtV.HP..LTPL.IT........YS.sEHFo..PG.s.P..........sHlPsDl.ssKp....Gls.RsPpssDlSsaYPLSPGsVGQIs...aPLGW..............................................................................................................	0	24	37	88
+8180	PF08348	PAS_6	YheO; 	YheO-like PAS domain	Fenech M	anon	Pfam-B_2023 (release 18.0)	Domain	This family contains various hypothetical bacterial proteins that are similar to the E. coli protein YheO (Swiss:P64624). Their function is unknown, but are likely to be involved in signalling based on the presence of this PAS domain.	21.10	21.10	21.10	21.30	21.00	20.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.58	0.71	-4.54	36	1856	2012-10-04 01:10:46	2005-08-11 09:50:25	6	5	1451	0	282	973	28	116.10	38	51.45	CHANGED	lLpsatsls-uluphhGspsEVVLHsL..cs.csolltIsNscloGRplG.sPhTph........uLctlpp.t..pppshtsYhspstcG.+hl+SsohhI+sspschlGhLCINh....Dlsshpth.pphLpt	........Lcsapsll-GLutll.Gsp.CElVLHsL..p....c..h..csShltIsNGchTGRplG.uPl.T-l.........AL.chL+c.....hp........cp..s......s...p...sYh....o+spsG.tlhKSsTlhI+s.c.ct.+.lI.GlLCINh..slss.h...pph...h..........................	0	69	132	209
+8181	PF08349	DUF1722		Protein of unknown function (DUF1722)	Wuster A	anon	Pfam-B_4169 (release 18.0)	Family	This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from E. coli.	21.20	21.20	21.30	21.40	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.20	0.71	-4.22	94	1436	2009-01-15 18:05:59	2005-08-11 09:51:49	6	6	1379	0	231	801	53	115.00	35	49.27	CHANGED	KhlLMAHs.ptY+pLGpllAshpphs.hcphhppYtptlMpALpphAoppspsNVL.HlhGYFKcpLssp-Kp-lhclIppYRpGhlPLlsPlTLL+Halpcas..ssYLtpQs.YL.pPaP	......................KhhlLAHSQstY+cl.GthlAsh.......ppht..l-shhppYppplhthLpcssohpspsNVL.Hl.GYF+ppls..spE+ppltpLIpp.YRpG.p.h.PlhsPL.shlKcahscYP..ssYLtpQpYhp.a.........................................	0	62	133	183
+8182	PF08350	DUF1724		Domain of unknown function (DUF1724)	Wuster A	anon	Pfam-B_1158 (release 18.0)	Family	This domain of unknown function has so far only been found at the C-terminus of archaean proteins, including several transcriptional regulators of the ArsR family (see Pfam:PF01022).	20.50	20.50	21.90	20.50	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.04	0.72	-4.44	67	138	2009-01-15 18:05:59	2005-08-11 09:55:08	5	7	40	0	120	138	7	63.20	29	23.56	CHANGED	Nsclalh.psslcl.uhs.VTDcahsLuLFscsGp.aDp.ptllSa-spAlpWGcELFpaY+ppucpl	..........Nhplalh.ppslcl.uhs.VTDchhhLuLapc....sGp.aDp..ptllSh.....-ppAlcWGp-LFpaYcppup.......	0	36	69	82
+8183	PF08351	DUF1726		Domain of unknown function (DUF1726)	Wuster A, Eberhardt R	anon	Pfam-B_3131 (release 18.0)	Family	This domain of unknown function is often found at the N-terminus of proteins containing Pfam:PF05127. Its fold resembles that of Pfam:PF05127, but it does not appear to bind ATP [1].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.71	0.72	-4.30	42	1117	2009-01-15 18:05:59	2005-08-11 09:57:59	6	15	1047	2	384	869	19	91.60	36	11.76	CHANGED	Yp-oc+l...LGpTashllLpshcslpPNhluRhl-sVcGGGllllLhsshpphcphhs..............................shcpph...hs..sat..clhtpFpcRFhtpLtpp.cshhlhD	..........pplLGppaphsVhDs.h...c....uhsssshAthsGTlcuGuhllLLls.s.h..pphcph.s..............................ssphRa...psp.sps........ss..s+Fsp+hh.psLsss.ppsh.............................................................	1	121	208	310
+8184	PF08352	oligo_HPY		Oligopeptide/dipeptide transporter, C-terminal region	TIGRFAMs, Fenech M	anon	Pfam-B_3025 (release 18.0)	Family	This family features a region found towards the C-terminus of oligopeptide ABC transporter ATP binding proteins, immediately following the ATP-binding domain (Pfam:PF00005). All characterised members appear able to be involved in the transport of oligopeptides or dipeptides. Some are important for sporulation or antibiotic resistance. Some dipeptide transporters also act on the heme precursor delta-aminolevulinic acid.	21.00	9.90	21.00	9.90	20.90	9.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.38	0.72	-3.62	59	28166	2009-01-15 18:05:59	2005-08-11 09:59:58	7	33	3987	0	6863	20640	4857	55.40	33	17.52	CHANGED	VEhGsspplh..psPtHPYTptLlsuhPphsstpp...........htuphP..shtphsp..................G..ChFtsRCshspst.C	...............VEtGs..sccl..a....ps..P..p......HPYTpuLL..u..u....l..P..p...hsst..t.....................h....t................................................................................................................................	0	1910	4134	5534
+8185	PF08353	DUF1727		Domain of unknown function (DUF1727)	Wuster A	anon	Pfam-B_2131 (release 18.0)	Family	This domain of unknown function is found at the C-terminus of bacterial proteins which include UDP-N-acetylmuramyl tripeptide synthase and the related Mur ligase.	25.00	25.00	29.30	28.40	22.00	18.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.45	0.71	-4.46	66	1470	2009-01-15 18:05:59	2005-08-11 10:01:48	5	4	1459	0	228	929	38	108.60	40	24.67	CHANGED	LlK..NPsGhspslshl........ssps......................................hslllhlN...sshADGpDsSWlWDsDFEpL.st.p.......lpplhsuG.RttDhAlRL+hA..Gls.............pphph..pp-hcpslpt..hppssscp..lYlL....sTYTAh	.....LsKNPsGhspuL.sh.lt......s.ts..............................................hsl...ll...hLN...uNh.....AD...GhD....sS.WIWDsDFEpl..sp.p.......ltp....lhs.uGs.R.tpDlAlRL+lA......Gls....................t....lh...tp-.lppslpp..hp..tps.spc.....shlL....uTYTAh.................	0	76	155	202
+8186	PF08354	DUF1729		Domain of unknown function (DUF1729)	Wuster A	anon	Pfam-B_3179 (release 18.0)	Family	This domain of unknown function is found in fatty acid synthase beta subunits together with the MaoC-like domain (Pfam:PF01575) and the Acyltransferase domain (Pfam:PF00698) [1].  The domain has been identified in fungi and bacteria.	25.00	25.00	40.10	39.20	20.80	19.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.77	0.72	-4.18	31	433	2009-01-15 18:05:59	2005-08-11 10:05:45	5	23	350	9	202	457	1	54.90	53	2.12	CHANGED	IPsLD-cFEhaFKKDSLWQSEDl-AVlspDspRVCILpGPVAspaos..pssEPlt-IL	..VPVlDc-hcpWa+pDSLWQSED.pth...DsspVCIl.GPsAVtthT..plDEPVu-lL......	0	48	111	168
+8187	PF08355	EF_assoc_1		EF hand associated	Wuster A	anon	Pfam-B_4111 (release 18.0)	Family	This region typically appears on the C-terminus of EF hands in GTP-binding proteins such as Arht/Rhot (may be involved in mitochondrial homeostasis and apoptosis[1]).  The EF hand associated region is found in yeast, vertebrates and plants.	19.10	19.10	19.40	19.60	18.20	18.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.49	0.72	-4.69	32	382	2009-01-15 18:05:59	2005-08-11 10:07:56	7	37	244	0	248	390	0	73.90	40	11.79	CHANGED	sW..pssa.sosspNp.tGhlTLpGaLuQWohsTaLDhppTLEYLuYLGass.....................................ssssAlpVTRtR+hcp+ptps	...............W..ssshsso.sssN-.tGal.TLpGaLuQWo.LoTaLDsppoLE.YLuYLGash..................................................................ttpt.s..pssAl..p..V.TRs++hDhc+tp.....................................................	1	68	122	190
+8188	PF08356	EF_assoc_2		EF hand associated	Wuster A	anon	Pfam-B_3018 (release 18.0)	Family	This region predominantly appears near EF-hands (Pfam:PF00036) in GTP-binding proteins. It is found in all three eukaryotic kingdoms.	21.50	21.50	21.70	22.00	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.97	0.72	-4.23	30	391	2009-01-15 18:05:59	2005-08-11 10:11:02	7	40	244	0	254	401	0	88.10	46	14.14	CHANGED	spPLsspsLtslKpslpcp.hPsuspp...pGlTlpGFLhLNplahE+GRHETTWsILRpFtYsDsLsLp-caLhPc..........hclPsssSsELSstGY	........................................pPLtspsLpclKp.llp+p...hs-G.Vtc...........sG.lTL..cGFLaLps..LFIp+GRHETTWslLR+FGYsDsLpLss-aLa.Ph..........lclP...s...ssosELs.puY.........................	0	71	126	194
+8189	PF08357	SEFIR		SEFIR domain	Fenech M	anon	Pfam-B_33671 (release 17.0)	Family	This family comprises IL17 receptors (IL17Rs, e.g. Swiss:Q60943) and SEF proteins (e.g. Swiss:Q8QHJ9). The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (Pfam:PF01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways [1].	21.40	21.40	21.50	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.82	0.71	-4.15	15	480	2012-10-02 18:56:14	2005-08-11 10:17:46	6	21	166	0	243	474	10	138.00	22	25.54	CHANGED	hKValsYuu.DsshahchVtphAphLpshh..GhEVslDLW-chclsp.G.hpWhtpp....lppushVlllhS.sh.thhcppsscpcusspspup...........t-hFhsshstl...l.p..p..spshp+alsVYF.shspppclPshLph..sspapL.cphsplhscL	.......................................+VhlsYSt...Dss.a...phVhphAphLpsh....GhcVh....lDl..a-p.p.........lt..t.u..hpWhtpp.................lpp....ss..hllllso.s.......h..hh.ptt.t.t.p..p..ps.s.s..t.tps................................................tshah..h.t..ht.h............ph..p......stsh.t.+als..shF..t...sppt......p..l..P..shhp........h.ha..p..h...pph.phh.t.........................................................	0	52	85	148
+8190	PF08358	Flexi_CP_N		Carlavirus coat	Wuster A	anon	Pfam-B_2014 (release 18.0)	Family	This domain is found together with the viral coat protein domain (Pfam:PF00286) in coat/capsid proteins of Carlaviruses infecting plants.	19.70	19.70	24.90	24.60	19.10	16.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.48	0.72	-4.19	25	358	2009-01-15 18:05:59	2005-08-11 10:18:53	5	3	50	0	0	371	0	51.70	47	17.60	CHANGED	RLspLp-hLppppsusplsNsuFEh.GRPsLc.sssM+sDsoN.sYsRPSlDtL	..RLspLhEhhtpcppsssloNsuaEh.GRPsLpssssMRtsPsN.PYuR.SlDtL....	1	0	0	0
+8191	PF08359	TetR_C_4		YsiA-like protein, C-terminal region	Fenech M	anon	Pfam-B_20730 (release 17.0)	Family	The members of this family are thought to be TetR-type transcriptional regulators that bear particular similarity to YsiA (Swiss:P94548), a hypothetical protein expressed by B. subtilis.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.54	0.71	-4.22	8	631	2012-10-03 00:15:22	2005-08-11 10:46:25	6	4	485	2	267	630	83	130.10	20	62.86	CHANGED	FcEKMGpFVE+IccchsstsospEKLtlLlcpHFptLuuDhcLAIVTQLELRQSNpELRhKINEVLKGYLsllDcIltEGhcpGEF+p-LDlRLARQMIFGTlDEsVTsWVMs-pKYDLsALucsVacLLlpG	..................................................................................thlpphcp.th..t.t.....p....s.shp+.Lth...llc....sHh...ph...l....t..p...s...p....s....l.....s.....h.l.h.....h...E..h.+.p.t..s..p..c..l.p...p.c.l..p.p.lh...+...p.....Y....hphlp...cllpcGhppGphc....s.-...ls....s.c.lspphlhGslp.th.lhphhh..s..p..t..p.hs..h.t.sp..hhthh...h........................................	0	121	209	240
+8192	PF08360	TetR_C_5		QacR-like protein, C-terminal region	Fenech M	anon	Pfam-B_96140 (release 17.0)	Family	This family features the C-terminal region of a number of proteins that bear similarity to the QacR protein (Swiss:P23217), a transcriptional regulator of the TetR family. QacR is able to bind various environmental agents, which include a number of cationic lipophilic compounds, and thus regulate the transcription of QacA (Swiss:P23215), a multidrug efflux pump [1]. The C-terminal region contains the multifaceted, expansive drug-binding pocket, which is composed of several separate, but linked, binding sites [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.51	0.71	-4.18	3	259	2012-10-03 00:15:22	2005-08-11 10:46:40	6	3	203	104	24	172	11	128.70	32	65.29	CHANGED	cppcWpEKWcccEKpYoTuTEKLYulAEasL.p-YppPLpNAIpEFuo-.ssosSIl-cMhuLsscslcsYcsIl-EGIQSGEFpI-NVcDlShIluuhLuGLssFhHEh-hcELc+LaNKAIsIFLpGlSs	................................................pW.-pWpcc....ph.h....pTspEKLYths-hhl..psl.p.pPlpp.....A.hpEF.p.hp..hhocp.l.-clht.lpc.c....hsha...cpLl-cGIpSGEFp....ps.sscslshIlsu.h.l.s.G.ls..s.h.ha...p.....s.h.c..chcc.lhpch.slhLpGhs............................................	0	11	19	20
+8193	PF08361	TetR_C_2		MAATS-type transcriptional repressor, C-terminal region	Fenech M	anon	Pfam-B_3020 (release 18.0)	Family	This family is named after the various transcriptional regulatory proteins that it contains, including MtrR (Swiss:Q6RV06), AcrR (Swiss:P34000), ArpR (Swiss:Q9KJC4), TtgR (Swiss:Q9AIU0) and SmeT (Swiss:Q8KLP4). These are members of the TetR family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [1,2,3].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.60	0.71	-4.20	12	1463	2012-10-03 00:15:22	2005-08-11 10:46:56	6	2	937	24	179	672	28	119.10	37	55.81	CHANGED	sPLpllRElLIalLpusVs-.+pRtlMEIlFHKCEFVGEMssl.phpcpLhhtsYsRIEpsLpcCIptt.LPssLch+RAAIhhRuhhoGlhENWLFsP-SFDLpp-AtsLVDshl-Mlph	..............................................................DPLphLREhLIhsLpthspp.RpptLhc.I.laHK.CEFs..sEMhsltptpcphshp..s.h.pplc....psLppChpt..thL.sssLsschAsIlh+uhlSGlhpNWL..hsP..p.....uaDLhKpA..shVshlLcMh......................................	0	27	74	128
+8194	PF08362	TetR_C_3		YcdC-like protein, C-terminal region	Fenech M	anon	Pfam-B_4012 (release 17.0)	Family	This family comprises proteins that belong to the TetR family of transcriptional regulators. They bear particular similarity to YcdC (Swiss:P75899), a putative HTH-containing protein. This family features the C-terminal region of these sequences, which does not include the helix-turn-helix.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.73	0.71	-4.47	16	1091	2012-10-03 00:15:22	2005-08-11 10:47:06	6	4	871	4	194	637	128	140.80	48	65.60	CHANGED	LcslL-sWLpshpsFcsps-PhpsLsuYI+sKlEhSR-hPpuS+lFAsEIhpGAPpl.s.LtppL+thscc+sslIptWlcpG+l.AslDPhHLlFsIWAsTQHYADFshQlpsVoG+sthscsta-pAscslppllLcGhtPc	.......................LcpIL-lWL.uPLc.s.F.c.t.-.hs.PltAlp.cYIRhKLElSRDaPpASRLFshEhltGAPhLhc..c..LsucL..Ks.L...l.-cK.u.A.lItuWlc....sG+.l.A.......P.lDPpHLIFhIWAsTQ.HYADFusQVcAVT.G...t.sh.t.s-shFsps.s-sVp+lIlcGlts...............................................	0	30	71	133
+8195	PF08363	GbpC		Glucan-binding protein C	Wuster A	anon	Pfam-B_3074 (release 18.0)	Family	This domain is found in the Streptococcus Glucan-binding protein C (GbpC) and also in surface protein antigen (Spa)-family proteins which show sequence similarity to GbpC [1].	21.00	21.00	22.60	26.10	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.72	0.70	-5.16	15	406	2009-01-15 18:05:59	2005-08-11 10:50:30	5	32	178	6	30	396	0	263.90	27	26.07	CHANGED	EpcKs-..DGaLo.cPpu.QuLVF-s.EPsAplolso...................thtpYsp+ph..phcshcl.pthpssstssushphhushssKtshop.hs.t........VlLc+GpslTsTYTNLpNSpYs....GKKISKlVYpYTlcsoop.ps...+lhlslasDPTlslFsuAaTGssc.+pssl.lcschpFYDEsGp.Ishss...ALlSluSLN+pps........uIEhsKsasGp..FlcIsGSSls.cpsGplYAscohsaKps..GS+ash........SsWDoss......uPsuWYGAGssph.oGsshphTlGupsss.s....................sIWFuhN	...........................................................................................................................................................................ctp..pu.ls.cs.u.psLsapp..EspA.h.s..hps.........................htph.tt.h..th..t...t.h.t.hpps.thht..s.p.th.h.sshsst.p.t................hh..lcpGpshosTYsNLps...upap.....G+K....IoKlh..apY.s.lpss.s.p...ps....ph..hhl.sDP.Thshhhu.......s.psps........p....th.hph.p.hp.Fa..DcsGp...lshsp.........ulhuhuSLNptts.......................phEhlp.s..h..s.sp......al.......IsGSoVsh.p.s.s.s...t......hYusps..phtps......Guphs............................ssWDs.ss.................................us.uaaGAushph.sssphsh....o.h.Gtpsts.s.....................shWFuhN..............................................................................	0	4	11	20
+8196	PF08364	IF2_assoc		Bacterial translation initiation factor IF-2 associated region	Wuster A	anon	Pfam-B_3037 (release 18.0)	Family	Most of the sequences in this alignment come from bacterial translation initiation factors (IF-2, also Pfam:PF04760), but the domain is also found in the eukaryotic translation initiation factor 4 gamma in yeast and in a hypothetical Euglenozoa protein of unknown function.	20.90	20.90	21.20	20.90	19.40	20.70	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.44	0.72	-7.78	0.72	-3.94	89	1458	2009-01-15 18:05:59	2005-08-11 10:57:39	6	17	1446	0	330	951	291	40.90	51	4.66	CHANGED	stc+lTLp.........R+ppopl+pshupG.....+s....KsVsVEVR..KKRshl+ps	...........tPcKLTLp.........RKTpSTl.p.lsu..ouG.............KS...............K.oVQVEVR..KKRTaVKRs......	0	70	174	253
+8197	PF08365	IGF2_C		Insulin-like growth factor II E-peptide	Wuster A	anon	Pfam-B_4175 (release 18.0)	Family	This domain is found at the C-terminal domain of the insulin-like growth factor II (IGF-2, also see Pfam:PF00049) in vertebrates and seems to represent the E-peptide [1,2].	21.00	21.00	21.50	22.00	20.20	20.60	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.89	0.72	-4.21	8	168	2009-01-15 18:05:59	2005-08-11 11:00:23	6	3	122	0	22	173	0	53.80	62	28.71	CHANGED	Ka.KYDlWQ.KSuQRLRRGlPAlLRARRaRhhAcclcAtcpAp.hHRPLhoLPopcP	......Ka.+..Y-..sWp.puAQRLRRGlPAlLRA++hRp.AcclcAhcpAh.hHRPLIuLPoc.P..............	0	1	4	10
+8198	PF08366	LLGL		LLGL2	Wuster A	anon	Pfam-B_4088 (release 18.0)	Family	This domain is found in lethal giant larvae homolog 2 (LLGL2) proteins and syntaxin-binding proteins like tomosyn [1].  It has been identified in eukaryotes and tends to be found together with WD repeats (Pfam:PF00400).	22.00	22.00	23.10	24.30	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.31	0.72	-4.14	12	358	2009-01-15 18:05:59	2005-08-11 11:10:57	8	12	89	0	195	366	1	104.40	45	9.98	CHANGED	PhpppsPaG........s.PCKuIpKl.a+ss.+supsFlIFSGGMPpsshGc+.pCloVhp.upspssL-hsppllDFhslsps..sschp-PhAlsVLLEc-LVllDLpssGaP	............................hpshhPa.G..........P.PCKsI.Kl....a..+os..c.s..up..sFlIFSG................Ghsh...ss.hGcR..slTVh+..G+stssL...-hsppllDFhTl.......s..........-s.s..h...............s..................s.-...........a......p-.....P......aAlVVLLEc-LVVlDLppsGaP........................	0	45	59	124
+8199	PF08367	M16C_assoc		Peptidase M16C associated	Wuster A	anon	Pfam-B_3062 (release 18.0)	Family	This domain appears in eukaryotes as well as bacteria and tends to be found near the C-terminus of the metalloprotease M16C (Pfam:PF05193).	25.00	25.00	25.90	25.40	24.90	23.90	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.32	0.70	-5.53	22	854	2009-01-15 18:05:59	2005-08-11 11:13:51	6	17	730	10	360	815	243	242.30	23	25.25	CHANGED	hpPcpshppcpspcEppcLcphhppLoEp-pcpIhcpuhpLpphQpppp...sLs.sLPsLslsDlscpscphslpppp.sshplhh+shsTNsIsYhchhhsls.slPt-hhPalsLassslspl.GTtshsYpphtppIphpTGGluhusplhssspsspphp.thtlsupALscpsschFplhp-llspscFsctc....Rl+.LlpphtuphssulssSGHsaAhshusupho.sutlsEphuGls.lchlpcL	.............................htPctshtpcppptp....ppcLpph....pts.L......o......c......c......-......hpp..l..hc.ps.tp.L....pph..Qp..p.c.............sls...pL...P..t........Lp..lpD.l....s..p..p..h.....p.........h.h.............h...p.................p......p.......h...............s.........s.............h....s...............l........hh.p.ph....T..NGlsYh..phhh........s........l........s...s........l........s....p....-.....h...............sa...lsLhsp.hlsp..............l.G.Ttph.s.a.tc.l.....pphlphpT.G.............G.lsh.....s...hp.....h.............h......s....s.........h....p......s.........h........s......p.........h...............p...s...t..........hh......l........su+s....Ls...pphschhcl.h.p-ll..........pp..sc...F.s...-pc.......Rl.+pllpptps..ph.pss.lhsuGHthAhtp.usuth.o.sut.h......p-.thsGls.hphlppl...................................................................................................................	0	144	229	310
+8200	PF08368	FAST_2		FAST kinase-like protein, subdomain 2	Vella Briffa B, Fenech M	anon	Pfam-B_2858 (release 10.0)	Family	This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis [1]. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.	26.90	26.90	26.90	26.90	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.05	0.72	-3.61	22	367	2009-01-15 18:05:59	2005-08-11 11:15:47	7	6	76	0	185	347	0	87.50	27	13.55	CHANGED	phph+LhpLstslpLEsP-a......psPhL.s...p........hspcstphpsh.ppltcsLpplL.Guppth+hsVhTsasaslDhEshLDpc.tpsLP	......................................hhtpLhpLstslpLE....tPtY......pGPh.L.tt..p.......hhspps.tph...shpppltcsLppLL.Gupph....hptslhsPasa........s.l..DhElhlDpp.tpsLP...........	0	26	39	86
+8201	PF08369	PCP_red		Proto-chlorophyllide reductase 57 kD subunit	Wuster A	anon	Pfam-B_2047 (release 18.0)	Family	This domain is found in bacteria and plant chloroplast proteins. It often appears at the C-terminal of Nitrogenase component 1 type Oxidoreductases (Pfam:PF00148) and sometimes independently in bacterial proteins such as the Proto-chlorophyllide reductase 57 kD subunit of the Cyanobacterium Synechocystis.	27.30	27.30	27.90	27.60	26.30	27.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.22	0.72	-4.09	132	610	2009-01-15 18:05:59	2005-08-11 11:17:14	5	21	408	2	163	571	349	46.20	42	10.64	CHANGED	Wss-ApttLc+.l....Ph.FVR....t+lR+ssEphApppGhsplTh-hlhp.A+	........Wss-ActELpK.I....Ph.FVR....s+l++NTE+aARcpGhpplTlEshhsAK...	0	45	93	131
+8202	PF08370	PDR_assoc		Plant PDR ABC transporter associated	Wuster A	anon	Pfam-B_2126 (release 18.0)	Family	This domain is found on the C-terminus of ABC-2 type transporter domains (Pfam:PF01061).  It seems to be associated with the plant pleiotropic drug resistance (PDR) protein family of ABC transporters.  Like in yeast, plant PDR ABC transporters may also play a role in the transport of antifungal agents [1, also Pfam:PF06422].  The PDR family is characterised by a configuration in which the ABC domain is nearer the N-terminus of the protein than the transmembrane domain [1].	22.70	22.70	23.30	23.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.01	0.72	-4.46	38	427	2009-01-15 18:05:59	2005-08-11 11:20:17	6	26	40	0	289	452	0	64.60	40	4.80	CHANGED	Wsphhsss..s....pTLGtslLcuRGlas-shWYWIulGALlGFsllFNhlaoLALsaLpPhs+upullS	.............Wpp..sss...s....polGhtlLcuRGlFs-s..hWYWIGlGALlGaslLFNllFslALsaLs..Phscspshl.....................	0	35	197	250
+8204	PF08372	PRT_C		Plant phosphoribosyltransferase C-terminal	Wuster A	anon	Pfam-B_3195 (release 18.0)	Family	This domain is found at the C-terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins.  It contains putative transmembrane regions.  It often appears together with calcium-ion dependent C2 domains (Pfam:PF00168).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.87	0.71	-4.72	29	485	2012-10-01 21:10:52	2005-08-11 11:26:41	5	13	121	0	278	450	4	140.40	36	18.93	CHANGED	LPTlFLYhFhIGlWp..YRhRPRtPP.HMDs+LSpA-u..spPDELDEEFDoFP.To+ssDlVRhRYDRLRoVAGRlQoVVGDlATQGERlQALLSWR..DPRATulFlhhCLlsAlllYssPh........+llsllsGh....YhlRHP+FRs.+hPSsPhNFFRRLPupoDshL	..........................................................................................hs.s.-s..h.p..DElD.E..E.hD.shs..ss.c......chl+h..RYctlpsVuu+.lQsllG-lAo.GERlpslhsWp..sPchoslhllh..h.hlusll..LYhsPh..........+hl.sllhGl...........ahhp+......+hRs.....t.h...P...s.....l..sF..hpRlPucsp................................................	0	51	143	213
+8205	PF08373	RAP		RAP domain	Fenech M	anon	Pfam-B_5583 (release 17.0)	Domain	This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain [1]. The domain is involved in plant defence in response to bacterial infection [2,3].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.82	0.72	-4.18	79	594	2012-10-11 20:44:44	2005-08-11 11:27:25	5	25	110	0	425	598	10	58.80	25	8.24	CHANGED	lElsGspHa..............hpso.pphp......spsth+p+hLpthG.apl.lplsaa....................-Wpph...sppp+hp.Y..lpch	..............................h.s.ppF.......................................................................spss..pphh..............Gppsh+cRpL..........p.t.h.G..a...pl.lplsaa....................EWpph.....pspppphp.YL+p............................................	0	160	211	306
+8206	PF08374	Protocadherin		Protocadherin	Wuster A	anon	Pfam-B_4100 (release 18.0)	Family	The structure of protocadherins is similar to that of classic cadherins (Pfam:PF00028), but particularly on the cytoplasmic domains they also have some unique features.  They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localised mainly at cell-cell contact sites.  Their expression seems to be developmentally regulated [1].	25.20	25.20	25.50	25.20	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.57	0.70	-4.71	7	319	2009-01-15 18:05:59	2005-08-11 11:47:02	6	13	55	0	124	322	0	198.20	47	21.31	CHANGED	oluNuollps.lt+SlcTPLspsIussspst.u..pphlsIhlullAGshsVlLlIhlsshlR.CRpspp+puhQtGKp..sp-ahoP..........ptps+p....pKt..KKcKK...........pKSsKs.h.shVTlcts+s--tht-phshplsL..-hpppohu+a.....hPssapPs............SPDLARHYKSuSP.PuhQLpPpoPsA.sKKHpllQ-LP.sNTFVGus..................ucssSouSDpaSs.pCposs.pa	..........................oluNuohlpsLl.t+Shc.TPLs.sIu.sss.p.t.s..pphlsIhlulVAGshsVlllIhlssll.R.CR.....psp.php.....uhQtuKp..sp-ahoP..........p.csKp.........pKt...KKc..K.K...........pK...SPKs.h.shVTlEtsKs--tst-t.hshplsL....-h-ppohu+a.....hPssatPs............SPDLARHYK.SuSP.PuhQLpPpoPsu.sKKHpllQ-LP.sNTFVGu...................ucssSouSDpaSs.pspops.ta.....................	0	5	16	57
+8207	PF08375	Rpn3_C		Proteasome regulatory subunit C-terminal	Wuster A	anon	Pfam-B_4098 (release 18.0)	Family	This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function [1].  It occurs together with the PCI/PINT domain (Pfam:PF01399).	21.20	21.20	22.90	21.80	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.39	0.72	-3.57	24	366	2009-09-11 08:23:08	2005-08-11 11:49:06	6	6	295	0	240	357	3	65.90	51	13.11	CHANGED	DlYSTp-PppsFcpRIpFCLpLHN-uV+AMRYPssppcpp.cpt.pppp-c-p....-ltccls-s.-hD..D	......DlYuTpEPQhAFHpRIpFCLslHN-uVKA......MRaPsssapp...-..lcsA...c-pREREp..-..ElAKEhsEt..D.D.................................	0	84	136	202
+8208	PF08376	NIT		Nitrate and nitrite sensing	Wuster A	anon	Pfam-B_37103 (release 17.0)	Family	The nitrate- and nitrite sensing domain (NIT) is found in receptor components of signal transducing pathways in bacteria which control gene expression, cellular motility and enzyme activity in response to nitrate and nitrite concentrations.  The NIT domain is predicted to be all alpha-helical in structure [1].	20.40	20.40	20.50	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.53	0.70	-4.85	118	931	2009-01-15 18:05:59	2005-08-11 12:01:15	5	47	468	2	424	987	49	239.30	17	31.40	CHANGED	husLlHpLQcER...........GhSusal....uSp......G.t...th....sspLtspRptoDpthsphpsthp........ph.ts.stt...........htpplsphhptLsp.LsslRppl.....Dshs.lsssps.hshYo.pllstlLsllsplsptsscsplspthsAhhshhpuKEtAGpERAllussaus.....sph.ssshhpchhshlupQpshh.cpFtsh..ussptpphapphhss...sshpp...lpphRphshs...........pss........tts.hs.hsupp.WFsts.Tp+I.....shl+pl.Esplss..plhpts	........................................................................h.spllptLQpER.............................sho.ssaL.............uus.......s...p..th........tsplppp+.tpoDpshsphppthp...........ph.tt.st............htptlsphhp.t.lsp.LsslRpp..l........................ss..tp...hs....s......sp.s....h.sh.Yo.pll..pt...l.......l.sh.h.t.......p.hs.....p....t...s......s...s.spl...sp...th...t.....u...h...h.......s.....l.......h.....p.....u+EhsutpRu.lhsss.hst..............................sp.h...sss...t....hpp......h.h....shhspp......p.....t....h.......h..pp.htsh..............us..s..p.t.....pphhpp.hhss.......sshpp......hpp...h.pp...th..hs...................................pss............tts..ht.....hs.s....pp...Whsh....totpl....sh....hppl.cpplhtph....h....................................................................................................................	1	142	295	380
+8209	PF08377	MAP2_projctn		MAP2/Tau projection domain	Wuster A	anon	Pfam-B_26981 (release 17.0)	Family	This domain is found in the MAP2/Tau family of proteins which includes MAP2, MAP4, Tau, and their homologs.  All isoforms contain a conserved C-terminal domain containing tubulin-binding repeats (Pfam:PF00418), and a N-terminal projection domain of varying size.  This domain has a net negative charge and exerts a long-range repulsive force.  This provides a mechanism that can regulate microtubule spacing which might facilitate efficient organelle transport [1,2].	18.20	18.20	18.30	18.30	15.50	18.10	hmmbuild  -o /dev/null HMM SEED	1134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.07	0.70	-14.11	0.70	-7.01	5	79	2009-01-15 18:05:59	2005-08-11 12:08:39	5	7	38	0	30	63	0	731.30	53	59.19	CHANGED	DKVADVPVSEATTVLGDVHSPAVEGFVGENISGEEKGTTDQE...KKETSTPSVQEPTLTETEPQTKLEETSKVSIEETVAKEEESLKLKDDKAGVIQTSTEHSFSKEDQKGQEQTIEALKQDSFPISLEQAVTDAAMATKTLEKVTSEPEAVSEKREIQGLFEEDIADKSKLEGAGSATVAEVEMPFYEDKSGMSKYFETSALKEDVTRSTGLGSDYYELSDSRGNAQESLDTVSPKNQQDEKEL.LAKASQPSPPAHEAGYSTLAQSYTSDHPSELPEEPSSPQERMFTIDPKVYGEKRDLHSKNKDDLTLSRSLGLGGRSAIEQRSMSINLPMSCLDSIALGFNFGRGHDLSPLASDILTNTSGSMDEGDDYLPPTTPAVEKIPCFPIESKEEEDKTEQAKVTGGQTTQVETSSESPFPAKEYYKNGTVMAPDLPEMLDLAGTRSRLASVSADAEVARRKSVPSEAVVAESSTGLPPVADDSQP.VKPDSQLEDMGYCVFNKYTVPLPSPVQDSENLSGESGSFYEGTDDKVRRDLATDLSLIEVKLAAAGRVKDEFTAEKEASPPSSADKSGLSREFDQDRKANDKLDTVLEKSEEHVDSKEHAKESEEVGDKVELFGLGVTYEQTSAKELITTKETAPERAEKGLSSVPEVAEVETTTKADQGLDVAAKKDDQSPLDIKVSDFGQMASGMSVDAGKTIELKFEVDQQLTLSSEAPQETDSFMGIESSHVKDGAKVSETEVKEKVAKPDLVHQEAVDKEESYESSGEHESLTMESLKPDEGKKETSPETSLIQDEVALKLSVEIPCPPPVSEADSSIDEKAEVQMEFIQLPKEESTETPDIPAIPSDVTQPQPEAlVSEPAEVRGEEEEIEAEGEYDKLLFRSDTLQITDLLVPGSREEFVETCPGEHKGVVESVVTIEDDFITVVQTTTDEGELGSHSVRFAAPVQPEEERRPYPHD.EELEVLMAAEAQAEPKDGSPDAPATPEKEEVPFSEYKTETYDDYKDETTIDDSIMDADSLWVDTQDDDRSILTEQLETIPKEERAEKEARRPSLEKHRKEKPFKTGRGRISTPERK.VAKKEPSTVSRDEVRRKKAVYKKAELAKKSEVQAHSPSRKLILKPAIKYTRPTHLSCVKRK	..........................................................................................................................................................................................................................................................................................................................t....t.......t...t......p.......p.p.h...s.tchph.h..t...D+SGMStYFETSsLK--h..sc..s..t...uSDYYELSss+t...-..sh...t.....p.tp.pt.............sh.EhuYSTLspsh..............st-ph.TlsPplht-Kp-..hhsKNKDD..LpLSRSLGLGGRSAIEQRSMSINLPhSCLDSluLGhshGRu+sLSPLAoDILopTSGShDEusD.YLPsTTPul-KhPsFP...h-stt.......t..............+.....s.t..p......p...sESP..ApphYKNGsVhuPDLPEMLDLsGoRSRLuS.ss-sEhsp+KSs.u-....h.-sts.t.hs.hssps...h.Ks-uQhE-hGYCVFscYosPhPSPsps......t...........................................................................................................................................................................................................................................................................E.s..+-..+..E.EhKEKs.sKPDLVHQEA...hDtE-sYp.oGtt....c..................t.....t...c.......c...p...p..........p...........p....p...t........pc....................h...h.t.......t.................t.....t........p.......t.p....c..h.t-...........s...-...................E.+uslESVVTlEDDFITVVQT.hD-uE.uuHSVRFus..p.-..ph..........t..cE.p.....-sp.Es......p-.sP...-sPAsPp+E.Els.SEhhTEoYDDYKDETTIDDSIMDsDSLWVDTQDDDRSIhTEQLETlPKEE+.A.......-K-.......sR....RsSL-KH.RKEKPh.Ko...G...R..GRI..STPERK.lAKKEPST.V.SRDEVRRKK..AVhKKAELuKKoElQuHSPSRKhILKPAlKaTRPT.HhSCVKRK................................................................	1	2	5	15
+8210	PF08378	NERD		Nuclease-related domain	Wuster A	anon	Pfam-B_9750 (release 17.0)	Family	The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins.  It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-11.32	0.71	-3.82	377	1767	2012-10-11 20:44:44	2005-08-11 14:40:20	6	64	1278	0	464	1715	271	125.70	17	30.27	CHANGED	pGttuEpts..t....phL.....pt.h.pp....h.h.h......ts.h.h.......................tt..pspIDhlllss.tt..lhllEsK....s.............hp.G......h....t..........h.....................................thts...Plpp.s....ppphptl....pph...l........................................h......hpslllhs	................................................uE..h.h.phL............pt.l.ppt...hhl.h.......ps.lhl...............ttspttpIDalllst..pG..lhllEsK......s.........................hp..G....p..lh....ss........tp..s....h.................................................h...t............................h.phts.......PlpQ..s..........tpphphl.....tph....l...........................................................h................................................................................................	0	152	325	415
+8211	PF08379	Bact_transglu_N		Bacterial transglutaminase-like N-terminal region	Fenech M	anon	Pfam-B_2190 (release 18.0)	Family	This region is found towards the N-terminus of various archaeal and bacterial hypothetical proteins. Some of these are annotated as being transglutaminase-like proteins, and in fact contain a transglutaminase-like superfamily domain (Pfam:PF01841).	21.50	21.50	21.60	21.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.48	0.72	-3.67	188	1621	2009-01-15 18:05:59	2005-08-12 17:21:43	5	8	789	0	617	1553	423	80.90	28	16.48	CHANGED	phplpHpTpYpYspPVshuhpplRLpP..pssst.........Qp.llsaplplsPtstphpp.hpDhaGNtlphh.sh.ppspp.c.lp...lpspupV-h	..............................hplpHpTpYpYsps.Vphu.phlRLpP.tspsp.........Qp.llsaplplp.......Pts....t...........hhst.tpDsaGNhlsthsh.spspp..p.Lp...lpspuhV-...............	0	164	370	493
+8213	PF08381	BRX	DZC;	Transcription factor regulating root and shoot growth via Pin3	Fenech M, Coggill P	anon	Pfam-B_2116 (release 18.0)	Domain	The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2]. BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway.  BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot [3]. The family features a short region of alpha-helix, approximately 60 residues in length, which is found repeated up to three times [1]. BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action [4].	24.50	24.50	24.70	26.80	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.98	0.72	-4.91	34	367	2009-01-15 18:05:59	2005-08-15 09:27:43	6	31	36	0	237	374	0	56.60	49	10.58	CHANGED	ssptEWl-QhEPGVYlThsshssG.sptLKRVRFSRcpFs.cppAcpWWpENps+lhcpYs	.....t..ppEWlEQsEPGVYITls..sLs.s......G.sp-LKRVRFS.....RcpFs.chpAcpWWtENps+lhcpYs......	0	32	143	192
+8215	PF08383	Maf_N		Maf N-terminal region	Fenech M	anon	Pfam-B_3103 (release 18.0)	Family	This region is found in various leucine zipper transcription factors of the Maf family. These are implicated in the regulation of insulin gene expression [1], in erythroid differentiation [2], and in differentiation of the neuroretina [3].	20.20	20.20	20.30	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.60	0.72	-4.40	9	171	2009-09-11 10:53:55	2005-08-15 09:39:28	6	2	45	0	78	126	0	34.90	59	11.59	CHANGED	spLE-LYWM..us..h.QQhs.PEuLsLTPEDAVEALIGs	...spLEDLYWM..uu...h.QQlN.PEALsLoPEDAVEALIut.......	0	5	16	35
+8216	PF08384	NPP		Pro-opiomelanocortin, N-terminal region	Fenech M	anon	Pfam-B_1053 (release 18.0)	Family	This family features the N-terminal peptide of pro-opiomelanocortin (NPP). It is thought to represent an important pituitary peptide, given its high yield from pituitary glands, and exhibits a potent in vitro aldosterone-stimulating activity [1].	20.50	20.50	20.50	20.60	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.54	0.72	-4.33	20	577	2009-01-15 18:05:59	2005-08-15 09:51:58	5	4	358	0	22	546	0	23.50	84	11.75	CHANGED	QCWE.so+C+DLsoEsslLECIcsC+sDLoAEoPlaPGNGHhQPho	................................SAESPVFPGNGHMQPLS..........	0	1	3	8
+8217	PF08385	DHC_N1		Dynein heavy chain, N-terminal region 1	Fenech M	anon	Pfam-B_3094 (release 18.0)	Family	Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit [1]. The region featured in this family includes the sequences implicated in mediating these interactions [2]. It is thought to be flexible and not to adopt a rigid conformation [1].	22.20	22.20	22.40	22.20	21.60	22.10	hmmbuild  -o /dev/null HMM SEED	579	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.78	0.70	-6.14	40	1478	2009-01-15 18:05:59	2005-08-15 10:01:37	7	120	275	0	1051	1462	56	440.20	18	14.51	CHANGED	DsshlppLpssVspWh+pIpplhphsps.st......sostsElpFWpshppsLppItpQLpu.cVphslclLcpu..Kp.phhssFps.t.slccuhscspchsphlcsh..hs-hL.tss....s..hsplppslsslhpplphhaphop..hs.pRhhsLlptIssplhpphpphL....ssp....p.lhp.h....-hs-hpphlps.shplhptaccpacchpshlcp.....tpccs.....ppaphp..tlhs+.hsphppRlppltphppsppph.pplhpt..................s.pst.hspslp...phtc.....-hppsacshpsls..sLDhssp...papsshppapp+hpclEpplsshlpct.h.sss.csspphF+llspFpsLh.hRPp.......Ipsslp.-htspLlcphcp-lcplpphFppph....p.tttphshh+shPs....luGsIhWs+pLpc+Lpph.hcplc...slh..s.....h.pps-.GpclppchsphpppLsp..pphappWhp...plppps..hslstsll..........pstsphcLh.VNF-spllpLh+El+hLthl..................s.........h..plPtshtplhpptcplhshtssLpchlcsasplhp.pl..pp.....hpt......Lltsphpclpphl.ptGls.lsWpsht..lptahp	........................................................................................................................hh..hpt.h..W.ptlpt...hht..p.t...........................s.s.tE.hpaW...th..............tth..l.pph.pt.t.h.hh...ht.hLp................pp................hh..........h..t........t.l.tth.pspp....hhtsh......p.l...t.....................p......p..h..p..h..l..lhphlph.hht.......sp........s....pRh....h...Lhpt......l...s...p.hhp.....hh...thl............s.t......p.lhp..............................ht.....h..phht...shphhp.app..h......th.pt..h..........t.t...............................t.a..ph.......hl..p.hp.h.pRht.p.l.....p..hhp....h.ph...th.....................................................................................................t....th........th.t..................php.t.h.h..p..h.p..p.h....p..............hc.ptt.............ta.p.t....shtt.....app.ph......tt....l-tplts......hhp.........pt.h.tph...t.sh..pp...................hh...ph...h...t.h..a..tt...lh........c.h.................lttt.....h..th...l..ht.h.tp-lpt.h.pp..........app...ph.......................tt......h...ps.........hP..........huut.lhWsppl.p+........l.pt..hphhp...........th.................................h.p....p...s........pth.......hpp....hpp.......h.......ht.lt.p.............t..haptWhp..........php....p.........................t...h....p....t..lh..........................................t.tthtl.............lNas.plhtlh.cEsc.h..h...............................................................t.........h..plP..h.phh.t..ptp..p..hh....h...tL..........hh.p.ap..phhp..th...............................Lh....t..htthp.th.l.....t.............u...h.........ltWps...........t...........................................................	0	416	544	845
+8218	PF08386	Abhydrolase_4		TAP-like protein	Fenech M	anon	Pfam-B_3096 (release 18.0)	Family	This is a family of putative bacterial peptidases and hydrolases that bear similarity to a tripeptidyl aminopeptidase isolated from Streptomyces lividans (Swiss:Q54410). A member of this family (Swiss:Q6E3K7) is thought to be involved in the C-terminal processing of propionicin F, a bacteriocidin characterised from Propionibacterium freudenreichii [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.41	0.72	-4.13	38	1197	2012-10-03 11:45:05	2005-08-15 11:43:12	5	9	575	0	480	3862	878	102.40	26	19.93	CHANGED	sPh..aGshhstshh..CssW............Ps..ssstshsphs.s...s...s.sslLllssptDPsTPapsApchsctLss..u....tllohpGt.GHsshh.ssspClsptlssYLhsGphPt.....tsssC	............................................................huthhu.s.h...Ct..h..W..............................Ps...tss..t...h.t...ht..s.....ts............s..sPlLllus.p.tDPsT...Ph.p......s.A.p.p.h.upp..h.ss....u........hl.l...o..hcGs...G...Hsu...h.........h...ts...........s......t...C...s.....s.ps......l.ssY.L.h.s.G.phPt......tshhC....................................	0	153	319	425
+8219	PF08387	FBD		FBD	Fenech M	anon	Pfam-B_1153 (release 18.0)	Family	This region is found in F-box (Pfam:PF00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes [1]. In fact, several family members are annotated as being similar to transcription factors.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.48	0.72	-4.50	129	806	2009-01-15 18:05:59	2005-08-15 11:49:10	5	32	19	0	451	833	0	49.30	25	12.21	CHANGED	ta...p..sslPcCLhopLchlph.p...........tapuppp.c.hcls.pYlLcNuphL.Kchslph	................................................s.cCl.spL.cplph.p............sapGpps..-..lphs..pallpNupsL.cphsl.............	0	116	212	319
+8220	PF08388	GIIM		Group II intron, maturase-specific domain	Fenech M	anon	Pfam-B_4063 (release 18.0)	Family	This region is found mainly in various bacterial and archaeal species, but a few members of this family are expressed by fungal and chlamydomonal species. It has been implicated in the binding of intron RNA during reverse transcription and splicing [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.88	0.72	-4.19	164	2393	2012-10-02 14:46:49	2005-08-15 11:52:43	6	14	1025	0	536	2190	222	80.40	24	19.71	CHANGED	l+phpp+l.+p.lh.+ptps.......hshpplIppLNPllRGWssYaphs.sspph..applDphlhp+LhpWth++ap..p.......ht...........pphhhp+.....ha	...............................pphpp+l...+p...lh....+.ptt.s...........hshpphlc....p.LN.hl+GWhsYaph..s...ss....pph...hpplD.phlhp+Ltthhh+ca+...p.......ht...........hh.........hh..........................................	0	205	383	464
+8221	PF08389	Xpo1		Exportin 1-like protein	Fenech M	anon	Pfam-B_4058 (release 18.0)	Family	The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1, Swiss:P14068). This region is found just C-terminal to an importin-beta N-terminal domain (Pfam:PF03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus [1,2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.74	0.71	-4.29	59	1456	2012-10-11 20:01:01	2005-08-15 12:46:41	7	30	320	21	1051	1452	11	147.50	19	14.93	CHANGED	pphlhsc..Lshslsplhhp.a....sppWps..hls-ll...shhps.s...............shsthhlplLphLsEElh-....htp..sphspp+.ppcl+ctlpsp......hpplhphhhplLpp.ts..................splhptsLcslssalp.....Wlslshlh.....s.s...llshl.hphL......s.sph..........ppsAhcCL	.........................................................t..hlhs+Lshsls.p.lhhppa......spp.Ws.s..hls-ll.........ph..hps..s................................................ststhhltlLphLsEElhs...................htp....tphspp+..pppl+.....p....t.....lppp.........hppl..h....phhh.....p.llppttp................................................splhptsLc.sltpalp........alslshl..h.................p..st........ll.p.hl.hp.hl..........p....h...........ht.shcs......................................................................................	0	370	587	863
+8222	PF08390	TRAM1		TRAM1-like protein	Fenech M	anon	Pfam-B_3108 (release 18.0)	Family	This family comprises sequences that are similar to human TRAM1 (Swiss:Q15629). This is a transmembrane protein of the endoplasmic reticulum, thought to be involved in the membrane transfer of secretory proteins [1]. The region featured in this family is found N-terminal to the longevity-assurance protein region (Pfam:PF03798).	25.00	25.00	25.00	25.00	22.70	24.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.04	0.72	-4.47	61	512	2009-01-15 18:05:59	2005-08-15 12:53:12	6	5	230	0	347	489	0	65.70	30	16.18	CHANGED	hsphFltlsYph................sssshYspGhcDhsaVhFYhlhhohlRthlhcallcPlu.+thslppp+p	...................................................hthFlhlpYpl...............................................sssshYst.GhcDlshVhFYhllhshlRshlh-alLcPlu.+phtlppp+..............	0	80	162	266
+8223	PF08391	Ly49		Ly49-like protein, N-terminal region	Fenech M	anon	Pfam-B_1187 (release 18.0)	Family	The sequences making up this family are annotated as, or are similar to, Ly49 receptors (e.g. Swiss:P20937). These are type II transmembrane receptors expressed by mouse natural killer (NK) cells. They are classified as being activating (e.g.Ly49D and H) or inhibitory (e.g. Ly49A and G), depending on their effect on NK cell function [1]. They are members of the C-type lectin receptor superfamily [2], and in fact in many family members this region is found immediately N-terminal to a lectin C-type domain (Pfam:PF00059).	30.00	30.00	30.50	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.67	0.71	-3.97	27	249	2009-01-15 18:05:59	2005-08-15 12:57:01	5	4	35	18	46	271	0	113.20	44	46.66	CHANGED	SVPWpLIVlsLGILChLLLVoVAVLsTpIFQYtQEKHph.pEsL.NhppphssMQsD.pLKEEhLpNKolECs.hps.......hL-sLpREQpRhapKTKohhsS.QcT.............G+tsEh+WFCaGlKCYYF	..........SVPWpLIVlsLGILChL.LLVhVsVLssp.IFQhtQ.cK+p.h..pEhL.Npppphs.....h.MQsDhpLK....EE.h..LpNKSlEsp.hpp.......hL-Sl.p+.-..QpRh.....apc..s+slh....c...o.pcT..............G+hs...c..aW.CaGhpCYYF.........................................................................	0	1	2	4
+8224	PF08392	FAE1_CUT1_RppA		FAE1/Type III polyketide synthase-like protein	Fenech M	anon	Pfam-B_1177 (release 18.0)	Family	The members of this family are described as 3-ketoacyl-CoA synthases, type III polyketide synthases, fatty acid elongases and fatty acid condensing enzymes, and are found in both prokaryotic and eukaryotic (mainly plant) species. The region featured in this family contains the active site residues, as well as motifs involved in substrate binding [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.77	0.70	-5.34	37	707	2012-10-02 12:25:54	2005-08-15 13:22:38	7	11	136	0	353	4319	396	250.90	42	57.47	CHANGED	ahhpRPR.s...VYLlDauCY+Psccp+lohpthhchsctssph.spcs.........lcF.p+llpRSGLG--TYlPculhphPsp..s..ohtpARpEuEtVhFuAlDcLFt+T......s.lpPc.-IGlLVVNCSlFsPTPSLSuMlVN+YKhRuslpSaNLuGMGCSAGlIulDLA+sLLp.sp..NoaALVVSTEslo.NWYhGscRSMLlsNCLFRhGGAAlLLSN..+st-+c.RuKYcLhHsVRTHpGADDcuapClhQcED-pGphGVuLS..K-LhsVAGcALKsNIsTLGPLVLPhSEpLhFhss.llt+Kl	..................................................................................................................hpRs+..s....lYLlDauCacPs.sp.h.....+........sshtthhch..p.h....t.......ph.....stps.....................lcF.p...+...ll...p...+SG.....l.......G.-.....c.........T...a.....h........P.......u...l.h...t.....h......P.sp................sh.t..t...u.........R........p........E..s..-....Vh....a........u.u.l...-.p....L.h.t+.T........s...lp.......P........c..-ls.l.L.l.V.N......s..S........h...F..s.P...T...P....S.Lo..uM.l...lN...+.Y.+h.R.s.s....l.t..o.a.NLuGM....GCSAGlI..ulD.LA+sl.L....p....sp.......s..s......hAlV....VSTEs..l.....o.............s...a.....Y.....h.....G....s.....p.....R.....u.......M.....L.....l.sNC.LFRh....G.G.A..Al.LL.S..N..........+........t.........t......t....t...+.............u.K..Y.....c.Lh...+..sV.RTHp..G..As..DcuapClhQcE.....D....p....p......G...p.hGlsL..S..K.-Lht.lAGc.AL+sNI.ss.LG..PlVLPhSEplhFhhs.hlh++.............................................................................................................	0	72	218	296
+8225	PF08393	DHC_N2		Dynein heavy chain, N-terminal region 2	Fenech M	anon	Pfam-B_3094 (release 18.0)	Family	Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (Pfam:PF08385) in many members of this family. No functions seem to have been attributed specifically to this region.	23.50	23.50	24.00	23.50	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	408	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.40	0.70	-5.96	94	2363	2009-01-15 18:05:59	2005-08-15 13:39:22	8	259	303	14	1713	2264	96	354.20	26	10.66	CHANGED	ppLpplpp-lpshpplWphhpphpp.phppatp.tsa.ppl...sspplcpplp...p.hhcphpplscph...pp...........hplhpplpp....plcpapphlPllps.L.+stuh........+...p.....R...HW.pplhp.hls.......sh.......t...ps..hoLpplls.hsl.h..patcplpcIsspAppEhslEptLpclcspWps......hpFphhsacs....p.....shllps..h--lhphL--phsplpohpsS........ahp....Fcpc.sppWcpcLshlpcll-hWhplQ+pWhYLEsIFsu..p..DIpppLPpEspcFppl-ppap.plhpps.ppsspllcss.t...sp.hhppLpphtcpL-plQKuLscYLEpKRptFPRFYFlSs--LL-IL..upup-Pp.tlQpHlpK.hF-uIsplphpppspp.......lhuhhSsE.G.Eplthtp.slphps......pVE..p...WLppl-ppM+poL+phlppulpphp	..............................................................................................................................................h.th.pphp.hpplaph.h..ph.p.th.pt.....hhp.t.a..p..l..........p.p..th...p...tpht........p..h..........p.....p.....h...t...p...h......c.th...pp.......................................hth.h.t...lpp..........pl....cph...h..p...hs..lltt..lps.uh...............+..p....................R..HW.ppl.p.h.ht...........hph.....p..................................ps...h...s.L...tplhp....hsl...h.........ph..tpp....l.pplstt.A.tp...Eh.s.lE....p.t..L.p.p..........htttWps..............................hph.ph....app......................p...........thhl..l.ps.....h-..-.l..hthl--p..htlps.hhsS........a.ht......F.ppp.lppWpp...pLsh......hppl.l....c.WhplQppW.......hYL...EsIF.u..........t...DI..t....pQ....LPp.E.....up.+F.pp..l-...pp.......ap..plM..........p...............ps........ps......s......p.....l.....l............ps............s.........t.........h................................s..hh...............p..........pLp....p.....htp........L...phhpK..u.LspYLE......pK...Rhh.....FP....R....Fa..........F.lSs...s-L..L-IL................u.p..s.p........s.st.....tlQ....Hl.pK.hF-s..ltplphpp.s.p................................hhuhh...S....t...E..G....Eh....l....h.....tp.............l.hps................pV.E..t........WLtpl.........tptMptol+phhtpuh.t..t.....................................................................................................................	0	747	940	1412
+8226	PF08394	Arc_trans_TRASH		Archaeal TRASH domain	Fenech M, [1]	anon	Pfam-B_18882 (release 17.0)	Family	This region is found in the C-terminus of a number of archaeal transcriptional regulators. It is thought to function as a metal-sensing regulatory module [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-8.04	0.72	-3.79	8	65	2012-10-03 05:12:49	2005-08-15 13:58:30	5	6	57	0	34	119	16	36.70	39	22.76	CHANGED	CDYCGpEIpG-PIshKh+N+lYYsCCsTCpcchKK+h	...........CDaCGppI..t..s..c..P..l..s.hK..h..ss.+s.YahCCsoChpph+cp......	0	8	15	27
+8227	PF08395	7tm_7		7tm Chemosensory receptor	Robertson H, Finn R, Fenech M	anon	Robertson H	Family	This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family [1,2].	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.36	0.70	-5.44	78	1580	2012-10-01 21:54:26	2005-08-15 14:17:53	7	10	51	0	884	2288	0	315.20	12	89.70	CHANGED	lchhhhhspl.hG..lhsh........phstpptphph.hphhhhhhhhhhhhhhhhhhhhh...h.hhhthhhhptsthhphhhhlhhhlthlshhhhhltthhppppltplhppl....hplppphtptspttt..........phhshhhhhhhhhhhhhhhhshh.............hhhtthhhhshhhlhhhhhhh....hh.hhhhhahhhlhhlh..phhphlpppLpphhppht.......................hpppshtp...............l..pplhphappl.hplspplsphas....h.ll..hhhhhhh.lthshhha..hhhtphh.............p.hhhhhhhl......ahhh.hhhhh......hhhhssstspp....pspcssthl..tph..........htttspphppp..lcpFhlphh.ppph....phsssGhFslspshlhshhuulhoYlllLlQFchtt	..................................................................................................................................................................................h.........h.s......................................h........h.h....hhh..hh..h..h.h...hhhhh..h..hhhh..............................................t....h.....p.....hh...h..........h..............h.h...h...........h...h.h...h.h..h.hh.h.......hh......p.......t..p...p..hh.....ph....h...pp.h...............hphptp.....h...th.th.....................thh.h.hh.....h.h...h.hh.h....h.h.hhh.hhhhh...........................................h..h......h...hh...h...h...hhh..h..hh..hh.......................h.hh......h.......h.h.h....h.h.......h....h.h..lh.............th...ht...hl..pptl...pt.hht....p.........................................tp.p..t.....................................................l....pphhphat.p....l...hp.h.s.p.p....hsp...has....h.hl...hhhhhth...hthh.h.ha......hhhhthh................................hh.h.hhhhh.........................h.hh.h.h.h..hh.......hhhhhs..pt..h.p............................phppht.hh..........hph........................s..tp.h..ppt.........lp....h.....h...th......pp..........thphhs..hh.ls.phhh..thhsshhsahlhhhQh.................................................................	0	345	411	732
+8228	PF08396	Toxin_34		Spider toxin omega agatoxin/Tx1 family	Bateman A	anon	Mondal S, Ramakumar S	Family	The Tx1 family lethal spider neurotoxin induces excitatory  symptoms in mice [1].	21.10	21.10	24.80	24.70	17.80	17.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.82	0.72	-3.43	7	30	2009-01-15 18:05:59	2005-08-15 16:18:18	5	1	8	0	0	34	0	51.30	46	76.95	CHANGED	CIclGs-CDG..cKsDCQCCRcNuYCSC..h...FG.hKsGCKCpVGssuphhulC.+cKppC.sp.....ssspCppsshs+Rp	....ClphGpsCDG..cKsDCQCCtcNuaCSC..h...as.hchs..CpC.ht...................................................	0	0	0	0
+8229	PF08397	IMD		IRSp53/MIM homology domain	Wuster A	anon	Pfam-B_4120 (release 18.0)	Family	The N-terminal predicted helical stretch of the insulin receptor tyrosine kinase substrate p53 (IRSp53) is an evolutionary conserved F-actin bundling domain involved in filopodium formation. The domain has been named IMD after the IRSp53 and missing in metastasis (MIM) proteins in which it occurs. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent [1].	20.50	20.50	20.60	20.70	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.32	0.70	-5.03	8	584	2012-10-03 12:17:00	2005-08-17 11:36:12	6	17	112	9	305	490	0	190.70	31	31.80	CHANGED	Y+sIMpQFN...PuLcNhlshGpsYc+ulpuhlhAucuYaDAlpKlGEhAssSps.S+ELGslLhcMu.sHRplpscLEchhpsFHcpLIspLEcKs-.DpKahssshK+YppEaKp+pcsL-KspSDLhKLc+Kupt...G+sst+hpl+Es..l-slsc+psplpcalucus+cALlEE+RRFCFLV-Kppslupp.huaaucuhshLpspL.sWpptsuDso+lP	................................hp....P.hcphlthupph.ptl....................pshs.Ast..s.......ah-.......Ah.....tK...........lu...-h...A..t...p................op.s..o...+...-..l.......G....ssLhphs.hHR..plpspLcph...h...p..shhppLls.Lp..cphE..t+...h.hs...t....hpKc.a...tp......Ea+pt..tpp.lcKppu.-.hh......KL......p+Kspt....................u+..ss...p......p..hcph.........lp.s....lssc.htl.p..p.h.ppuh...+pALlEERpRaChhlphhpsls................pp.hshhsc.hp...h....Lp..thh..hpthst-spclP.............................................	2	68	101	199
+8230	PF08398	Parvo_coat_N		Parvovirus coat protein VP1	Wuster A	anon	Pfam-B_2198 (release 18.0)	Family	This is the N-terminal region of the Parvovirus VP1 coat protein. Also see Parvovirus coat protein VP2 (Pfam:PF00740).	26.60	26.60	26.60	26.70	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.17	0.72	-4.18	11	1185	2009-01-15 18:05:59	2005-08-17 11:58:51	5	6	140	0	2	856	0	57.20	59	11.36	CHANGED	LPGY+YLGPGNuLDpGcPVNtuDuAA+cHDhuYsp.LKsGcNPYlpaNpADpcFlccLccDTSF	.......LPGhpYlGPGNt....L....ps....G.P.P.psssDuAA+hHDhpYuphhK.G.NPYh.hashADpch.cplppt.s...............................	0	1	1	2
+8231	PF08399	VWA_N		VWA N-terminal	Wuster A	anon	Pfam-B_2075 (release 18.0)	Family	This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, Pfam:PF00092) and Cache (Pfam:PF02743) domains.  It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits [1].	20.70	20.70	20.90	20.80	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.56	0.71	-3.50	11	476	2009-01-15 18:05:59	2005-08-17 12:04:57	6	21	88	0	252	411	0	113.30	37	11.56	CHANGED	AEps..ptpHpaptslt.pphpYYsA+hhs-hsc...........-sstsEhu.....hph.hpccspFpN.sVNhohSuVplPTslYpcsstlLNslpWocuL-sVFhcNhccDPoLpWQYFGSuTGhhRhYPAspW	.....................................................................Acphp...taph.p.sh......htYasuhh.sch.sp...............t.s.s.-ht.........hch.ht..sspFps..Vsh.shS.s.VplPTslY.pt.ss.llNslpWo..cuLs..pVFhc.....N...hcpD.PoLhWQYFGSuoGhhRhYPu.htW............	1	68	89	164
+8232	PF08400	phage_tail_N		Prophage tail fibre N-terminal	Wuster A	anon	Pfam-B_3101 (release 18.0)	Family	This domain is found at the N-terminus of prophage tail fibre proteins.	26.60	26.60	26.60	27.00	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.58	0.71	-4.45	9	1004	2012-10-02 19:08:27	2005-08-17 14:13:30	5	47	343	0	14	1041	4	125.20	65	25.71	CHANGED	MoVpISGlLKDGsGcPVssssIpL+Ap+sSsTVlssTVAos.s-psGpYuhclE.GpYsVhLts-GhsssasGsIsVhsDSpPGTLNsFL.tAhsEsDlpPEllpcFEthstpsscsAusuttssppAspsutsA	......MuVpISGVLKDGsGKPVpNCTIpLKA+RsSoTVV.....VNTVASENPD.EAGRYSMDVEaGQYSVhLLVEGF.P.PSHAGTITVYEDSpPGTLNDFL.GAMoEDDlRPEALRRFEhMVEEsARpAptAppNAupAcpSupsA....................	1	1	2	7
+8233	PF08401	DUF1738		Domain of unknown function (DUF1738)	Fenech M	anon	Pfam-B_3014 (release 18.0)	Family	This region is found in a number of bacterial hypothetical proteins. Some members are annotated as being similar to replication primases, and in fact this region is often found together with the Toprim domain (Pfam:PF01751).	20.60	20.60	20.60	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.68	0.71	-4.40	112	907	2009-01-15 18:05:59	2005-08-17 16:38:04	6	25	579	0	235	850	162	122.50	28	26.43	CHANGED	+tclY.pclTc....cIIspLEp.G.stPWhpPWp.....tsssshshPhN.toGcsYpGlNllhLWhss.tpGas.....sspWhTa+QAppLG...........upVRKG.E+uosl...laacp..hppc.....pp.t........ps.ptptcpl..shl+tasVF	..................................p..shhpplss.......plI.ttlEp.....G.shPWh+PWp.......tsthshPhN.ho...GctYpG.lNslh...Lh.h.ts..tpGas.........sspWhT.a+Q.Ap.p.h....G....................................................u..pV+..KG..E..+us.sl...laaph......hpcp............t.p.t...................tptptphpth....shh+tapVF.............................................................................	0	46	136	189
+8234	PF08402	TOBE_2		TOBE domain	Bateman A	anon	Pfam-B_4178 (release 18.0)	Family	The TOBE domain [1] (Transport-associated OB) always occurs as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulphate (Swiss:P16676). Found in ABC transporters immediately after the ATPase domain. In this family a strong RPE motif is found at the presumed N-terminus of the domain.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.46	0.72	-3.98	128	14426	2012-10-03 20:18:03	2005-08-18 14:22:02	5	12	3742	54	3382	10860	3488	74.40	20	20.70	CHANGED	lulRPE+lpl...................ss...s....s..sl....sGpVpphtahGspshht.lclsssphhhs...ttssst........ht..hGcpVtlsasscsshlh	..............................lulRPE...c.l.pl........................................ss...s........s....sl........pu...p..V..ps...h...p..ah...Gsph......h.......h.....h....l..........c........h........s.......s........s....p....h.......hhs.................ph.sspt............hp............hG..p.p.l.tlsh.s.spphhlh...............................................	0	780	1829	2550
+8235	PF08403	AA_permease_N		Amino acid permease N-terminal	Wuster A	anon	Pfam-B_3112 (release 18.0)	Family	This domain is found to the N-terminus of the amino acid permease domain (Pfam:PF00324) in metazoan Na-K-Cl cotransporters.	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.65	0.72	-4.66	16	266	2009-01-15 18:05:59	2005-08-18 14:58:10	5	5	64	0	109	240	0	70.70	44	7.06	CHANGED	pcstsppshhpshGasTlDsVPplDFYpNouuhut.+tsRPSLp-LHcshccsss...ssht-sssst...sGsss-	............coHosTaYlpTFGHNThDAVPpI-aYRNTuu...s.G..Kh.sRPSLtELH-p.LcKt.......shtDshusG...-uh...............................	0	15	25	55
+8236	PF08404	Baculo_p74_N		Baculoviridae P74 N-terminal	Wuster A	anon	Pfam-B_3059 (release 18.0)	Family	This domain is found at the N-terminus of P74 occlusion-derived virus (ODV) envelope proteins which are required for oral infectivity.  The envelope proteins are found in baculoviruses which are insect pathogens.  The C-terminus of P74 is anchored to the membrane whereas the N-terminus is exposed to the virion surface.  Furthermore P74 is unusual for a virus envelope protein as it lacks an N-terminal localisation signal sequence [1].\	  Also see Pfam:PF04583.	25.00	25.00	27.10	26.60	19.20	19.00	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.88	0.70	-5.66	26	102	2009-01-15 18:05:59	2005-08-18 15:00:00	5	2	71	0	0	99	0	268.90	44	46.86	CHANGED	TslDlhNAspYusphppLcaI.+WRs+FPHIh..IDYsIRsA.oNs.DYYVPssLts+.AlsVcLpFS+cGCESMSCYPasETGsI-h.pTPhG.YTQTS-TuVtYuQ..PACYsLD+AuAsR-GsEtclQosELRYosss+.CIlVDohoKMYhNSPYlRT--Hll+GVDDV.PuFNVts.ssDPlFPE+acGpFN-AYCRRFGRsl..N......suCohpWWEollGFVLGDoIahTFKLLssNVFo-LRsFDYp+PSslLPstPss-upp.lLp-WtssRDsslDh.-hEtpFhphp..shs-lsl...sssppLlYsAppGF	........ThhDhhNAspYu.phtpLpaI.+WRp+hPHIh..IcYplR.A.s.ss.DaYVPstltp+...AlhVcltFS+cGC-.u.MSCY.Pap....ETGsls..pTshs.YTQTS-......Ts..lt.Y...sQ..PACYpLDRuuAh......R-Gt-pplQusEhRYo..spp.ClhV..DohoKMYh...NoPYlRT--HhlhGlDDV.PuFNVts.....s...sDshFP............E+F+GpFNcAYCRRFGRph..N......suCshpWWEollG.FVLGDTlYhThKhlssslao-LRsaDYp+PSs.lLPs..Phssupp..hLspW+ssRDsssch.-hEh.F.p....phsclsh....s...pl.YhAE.Ga...............................	0	0	0	0
+8237	PF08405	Calici_PP_N		Viral polyprotein N-terminal	Wuster A	anon	Pfam-B_4167 (release 18.0)	Family	This domain is found at the N-terminus of non-structural viral polyproteins of the Caliciviridae subfamily.	24.20	24.20	24.40	44.80	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.98	0.70	-5.62	6	386	2009-01-15 18:05:59	2005-08-18 15:01:23	6	4	326	0	0	369	0	351.20	73	21.29	CHANGED	RsspPApEPlIGshLEha-G+IYHYuIYIGpGKslGVHsPpAAhSlA+lslpPIuhWWRssYsPp...hLo.DpLKcLcsEsaPYsAhTNNCYpFCC.VhsLpDTWLpRRhIo.ostFa+PsQDWs+cs.-h.pDSKLchVpDAlLsAlsuLlS+PhKDLLGKLKPLNlLNlLusCDWTFhGlVEsVILLhELFGVFWsPPDVSNFIASLLsDacLQGPEDLAhDLVPlVLGGIGLAlGFT+-KluKhhpSAssuLRAAppLGpYGLEIFpLlhKaFFsu-psc...cTL+sIEsAVIDMEslussplTpLlRDKpSupsYMphLDtEEEKARKLSsKsAsPclVuTTNALlARIShARSAL	......RENRDAKEPLTGTILEMWDGEIYHYGLYVERGLVLGVHKPPAAISLAKVELTPLSLaWRP..VYTPQ..YLISPDTLKKLHGETFPYTAFDNNCYAFC.CWVLDLNDSWLSRRMIQRTTGFFRPYQDWNRKPL.PTh.DDSKLKKVANIFLCsLSS...LFTRPI..KDIIGKLRPLNIlNILASCDWTFAGIVESLILLAEL.FGVFWTPPDVSAMIAPLLGDaELQGP.EDLsVELVPVVMGGIGLVLGFTKEK....IGKMLSSAASTLRACKDLG...AYGLEILKLVMKWFFPKKEEAN.ELAMVRSIEDAVLDLEAIENNHMTTLLKDKDSLATYMRTLDLEEEKARKLSTKSASPDIVGTINALLARIAAARSLV.................................................................................	0	0	0	0
+8238	PF08406	CbbQ_C		CbbQ/NirQ/NorQ C-terminal 	Wuster A	anon	Pfam-B_3065 (release 18.0)	Family	This domain is found at the C-terminus of proteins of the CbbQ/NirQ/NorQ family of proteins which play a role in the post-translational activation of Rubisco [1].  It is also found in the Thauera aromatica TutH protein which is similar to the CbbQ/NirQ/NorQ family [2], as well as in putative chaperones.  The ATPase family associated with various cellular activities (AAA) Pfam:PF07728 is found in the same bacterial and archaeal proteins as the domain described here.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.42	0.72	-3.97	81	795	2009-01-15 18:05:59	2005-08-18 15:03:12	5	4	655	0	191	519	390	86.40	31	30.94	CHANGED	EspIVucEo.GlspspAtpLVplApplRsL..cGps....L-EGsSTRLLlYAApLlssGlsstpAscsAllcPLTDDs-l..tpuLpchlsuha	............E.tllt.cp..o...u.l.s.c.p.h.s...pplVchupclRsl........ptps.............l-Eus.STRhLlhhupLl.s........t.shss....c....c....A.....hctsllcsL...s..D..-...-h..hpAlhphht...h......................................	0	57	127	167
+8239	PF08407	Chitin_synth_1N		Chitin synthase N-terminal	Wuster A	anon	Pfam-B_1105 (release 18.0)	Family	This is the N-terminal domain of Chitin synthase (Pfam:PF01644).	19.40	19.40	20.90	19.80	18.70	17.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.93	0.72	-4.29	55	491	2009-01-15 18:05:59	2005-08-18 15:04:37	6	9	174	0	331	510	1	79.90	43	8.49	CHANGED	+Rtps..h.....++lp..Lh...pGsllh.D.......sPVPstLhst.lst........psssEFoaMRYTAs.TCDPs-Fs.cpuasLRpt.hYs..RcTELhIslT	.................h...hsh+cVpLh.....pGsllh.D.......sPlPstLhstlsp........sspcEFTHMRY.TAs.TC.DPs..-Fs.cp.........GasLRtt.has..RcTELhIslT...........	0	99	186	287
+8240	PF08408	DNA_pol_B_3		DNA polymerase family B viral insert	Wuster A	anon	Pfam-B_3028 (release 18.0)	Family	This viral domain is found between the exonuclease domain of the DNA polymerase family B (Pfam:PF03104) and the Pfam:PF00136 domain, connecting the two.	24.50	24.50	24.70	24.80	22.00	24.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.11	0.71	-4.33	13	96	2009-01-15 18:05:59	2005-08-18 15:05:26	5	3	53	0	0	90	8	143.70	69	14.78	CHANGED	SKNsFsCsstlc.phssshhphhussssDs+sKlplFu-VLpTGNYlTIs-.claKIlcK.cIt..c-uFpl....sltsspshth....ssh......hsluFGKDDVDLuD..MYtNYsL-hAl-MupYClHDACLCKYLWsYYtIcoKIsAuAsTYlLPQshsFEY	...................SKNAFuChuKVL.scGscEMTFIGDcTTDAKGKAAsFAKVLoTGNYVTVD-.hICKVI+K.DIa..ENGFKV....lLsCPs........NDT......YKLSFGKDDVDLAp..MYKcYNLNIALDMARYCIHDACLCpYLWEYYGVETKTDAGASTYlLPQSMVFEY.........	0	0	0	0
+8241	PF08409	DUF1736		Domain of unknown function (DUF1736)	Wuster A	anon	Pfam-B_4104 (release 18.0)	Family	This domain of unknown function is found in various hypothetical metazoan proteins.	21.70	21.70	22.40	22.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.59	0.72	-4.41	30	412	2009-09-10 21:08:40	2005-08-18 15:06:46	6	202	109	0	252	413	12	78.60	43	10.48	CHANGED	lhsptsPt.FopsDNPsuhssphhoRhLTapYLhsh.NhWLLLhPssLsaDWoMsuIPLl...coltDhRNlholhhasslh...lL	..................hssp.Ph.Fop...DNPAuhus.hhs.RtLTasYLhsh.NhWLLLsPsp..LCaDWoMGsIPLl.....colhDhRNlsTlshassLh...l......	0	83	103	178
+8242	PF08410	DUF1737		Domain of unknown function (DUF1737)	Wuster A	anon	Pfam-B_2030 (release 18.0)	Family	This domain of unknown function is found at the N-terminus of bacterial and viral hypothetical proteins.	20.60	20.60	20.60	24.50	20.30	18.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.67	0.72	-4.19	19	1062	2009-01-15 18:05:59	2005-08-18 15:07:52	5	3	451	0	59	981	214	52.20	58	13.11	CHANGED	M.Kh.....YRhlTusDsusFC+R.VTpALscGWpLaGSPshuasu.tthhtsuQAV....lK-l	...........MshKH......YDVVRAASPS.DLAEK.LTcKLKEGWQPaGuPlAhTs........asLMQAlstE.G.............	0	16	35	46
+8243	PF08411	Exonuc_X-T_C		Exonuclease C-terminal	Wuster A	anon	Pfam-B_3061 (release 18.0)	Family	This bacterial domain is found at the C-terminus of Exodeoxyribonuclease I/Exonuclease I (Pfam:PF00929), which is a single-strand specific DNA nuclease affecting recombination and expression pathways.  The exonuclease I protein in E. coli is associated with DNA deoxyribophosphodiesterase (dRPase) [1].	20.00	20.00	23.80	22.50	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.85	0.70	-5.37	74	1111	2009-09-11 17:37:21	2005-08-18 15:09:21	5	3	1089	6	187	830	1335	260.60	49	55.39	CHANGED	RpKcpltphlDl....hphpPLlHVSGhauut.pussuhlsPlAaHPsNpNAVIshDLstDsssLlc.......Lsu-plRpRLYTc..+s-Ls-s.th.lPlKhlHlNKCP.llAPspsLps..........-sAp.....RL...GlDtptstpphphL+pp....sp.lp-Kltplas.......pp.pas..sssDsDtpLYs.GFF.ussD+pthchlR..pssPppLup..hphsFpDpRltcLLFRYRARNaPcTLsppEpp+Wppa........ppp+Lpssp......hppahppLppLhpp......ppss...cchplLpsLhpYuppL	.......................................................................RsK+KlhsLIDl....spMpP.LVHVSGMFGAh.RGsTSWVuPLA..WH.PcN+NAVIhsDLA.u.Dh.oPLLE.......LDu-sLR-RLYTt........+sDL.u-..pssVP..lKLVHINKC.P.VLA...Ap.T.LcP..........Ec.A-.....RL...GIsRppCLcNLplLRps.....Pp.lREK.VlslFup......tc.sFs....sS-s..VDsQLYs.G.....FF...S-A.DRAsMcIlh....pT.c.PcsLsu................L-lsFsD.cRIc...c...L...LFpYRARNFPs.TLstuE.QpR.WhcH......................RRphhssch...........lpsYtpcLp.Lspp........as.-..Dc......cKluLLKuLapYApc.h......................	0	38	88	143
+8244	PF08412	Ion_trans_N		Ion transport protein N-terminal	Wuster A	anon	Pfam-B_4115 (release 18.0)	Family	This metazoan domain is found to the N-terminus of Pfam:PF00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.	20.60	20.60	20.60	20.70	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.69	0.72	-4.67	9	383	2009-01-15 18:05:59	2005-08-18 15:10:34	5	12	89	0	232	371	6	66.70	47	8.90	CHANGED	QhtuhLQPslNKhSL+hFGScKAVpcEQ.Rl+oAGsWIIHPaScF.........................................RFYWDLhMLhLhhuNLIlLPVuITFFpDpsos	................................hh.PtsN+huh+ha.GSpKAl.pEp.R...c.s.u.....G.hW...lI.HPhSsF........................................................RFYWDlhMLllhVuNLIIlP.VuIoF..Fp--.o.....................	1	91	116	169
+8246	PF08414	NADPH_Ox		Respiratory burst NADPH oxidase	Wuster A	anon	Pfam-B_2127 (release 18.0)	Family	This domain is found in plant proteins such as respiratory burst NADPH oxidase proteins which produce reactive oxygen species as a defence mechanism.  It tends to occur to the N-terminus of an EF-hand (Pfam:PF00036), which suggests a direct regulatory effect of Ca2+ on the activity of the NADPH oxidase in plants [1].	21.90	21.90	23.80	23.50	21.30	20.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.26	0.72	-3.92	28	221	2009-01-15 18:05:59	2005-08-18 15:13:29	5	16	30	2	128	252	0	93.50	49	11.45	CHANGED	RLDRo+S.uAt+AL+GL+FIo+ssus..s.G...WspVEpRFsclss..-GhL.RucFucCIGMs..-SKEFAsELFDALARRRplp.s-sIsK-pL+EFW-QIoDQSFDS	...........phcRo+.S.uAt+AL.+GL+Flspssss...t.u...........WtpVEcRFcpLut.....-G.....hLsRscFupCI.........G.Mp......-SKEFAsELFDALuR.RR...plp....h..........ssIoK--L+EFWpQIoDpSFDo......................	0	16	81	103
+8247	PF08415	NRPS		Nonribosomal peptide synthase	Wuster A	anon	Pfam-B_1156 (release 18.0)	Family	This domain is found in bacterial nonribosomal peptide synthetases (NRPS).  NRPS are megaenzymes organised as iterative modules, one for each amino acid to be built into the peptide product [2]. NRPS modules are involved in epothilone biosynthesis (EpoB), myxothiazol biosynthesis (MtaC and MtaD), and other functions [1].  The NRPS domain tends to be found together with the condensation domain (Pfam:PF00668) and the phosphopantetheine binding domain (Pfam:PF00550).	20.90	20.90	20.90	21.60	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-9.06	0.72	-4.20	144	1536	2009-01-15 18:05:59	2005-08-18 15:14:43	5	209	643	0	259	1385	12	57.50	37	3.74	CHANGED	HpthSGVc.VlR.-LsRp.......tsss........shhPVVFTSsLuhss............tsstshhGph...s.aslSQTPQ	.....HppaSGVc.VhR.-Ls+p.....psts.........shhPVVFTSsLGhst.t.............ttspphhGc......saslSQTPQ...............	0	45	137	215
+8248	PF08416	PTB		Phosphotyrosine-binding domain	Wuster A	anon	Pfam-B_3174 (release 18.0)	Family	The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus.  Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix).  Human tensin has actin-binding sites, an SH2 (Pfam:PF00017) domain and a region similar to the tumour suppressor PTEN [1].  The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.56	0.71	-4.24	14	631	2012-10-04 00:02:25	2005-08-18 15:15:56	8	20	96	7	308	1087	1	127.00	29	14.53	CHANGED	QapVpHLsThsh-sppuhpslcDslppLphLsupG+lWsQshllpVsspuloLhD.poKp.L.EpaPLsolpaspsshpsppasS...............lLulVspcsspupssl.HlFp..ElcAp.ltpsIpsslschhhsp.p+	...........................................................thpV...aLsohph-..shs.Ghps.lpc..t....p..h...t.....t........L.......s.......t.........p......s...p......s....h..s.......p.......l..........hh.cVssp.uloLhD.......sp...p..K....................................h....cp.......YP.......lsolp....assh...s..s...p...s...p...pa.ss...............................lhuhVs....+c...s....p........s.....p.....s...s..l....HlFt.....El...c...sppssssI.shlsc.h.st.................................................................................	1	54	78	174
+8249	PF08417	PaO		Pheophorbide a oxygenase	Wuster A	anon	Pfam-B_3102 (release 18.0)	Family	This domain is found in bacterial and plant proteins to the C-terminus of a Rieske 2Fe-2S domain (Pfam:PF00355).  One of the proteins the domain is found in is Pheophorbide a oxygenase (PaO) which seems to be a key regulator of chlorophyll catabolism. Arabidopsis PaO (AtPaO) is a Rieske-type 2Fe-2S enzyme that is identical to Arabidopsis accelerated cell death 1 and homologous to lethal leaf spot 1 (LLS1) of maize [1], in which the domain described here is also found.	20.90	20.90	21.00	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-10.21	0.72	-4.06	29	296	2009-01-15 18:05:59	2005-08-18 15:35:27	7	5	102	0	163	309	25	97.40	26	20.94	CHANGED	F.APChhhps.......................hsscs.tclttlhhChPsu.G+oR.....LlhRashsF......sthhh+lhP...RWapHl.spspVL-pDhhhLctQc+hltp..Gsss......app	...........................................................FhsPChhhsp..........................h.ptppttphhh..lhhslPsus..G+oR.....l...l...hp.hshsF.............................sthhhph..lP......cWa......pHh..st.spVL-pDhhlLptQ-chhhp....s...................	0	41	111	141
+8250	PF08418	Pol_alpha_B_N		DNA polymerase alpha subunit B N-terminal	Wuster A	anon	Pfam-B_4046 (release 18.0)	Family	This is the eukaryotic DNA polymerase alpha subunit B N-terminal domain which is involved in complex formation [1].  Also see Pfam:PF04058.	21.10	21.10	21.80	22.00	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.53	0.70	-4.84	27	272	2009-01-15 18:05:59	2005-08-18 15:36:04	5	9	224	16	181	279	0	213.00	20	36.09	CHANGED	FGsss....ss-llpcLpslhplaslos--Lah+WEuFshpp..spp.p.p.LslpsLcpFccplppphp+pspstht.............tphpphhpssttct.hl.t.sssushhuhhpt.sTPshtpp+h..................................sspsp....htoPsstssstssss................................................................phsp..+pssGpll-olNsch...sps......hsssscsc.....l+lssph-sp+apY+sMh.+L.-uu-VLD-pI-chsplh.pcpaplsp..pFGsPsl.SQ	......................................................ptplltch.plhhhash.s.sp-hh.cW.u....ashph....tts.t.....lshpslptF.cppltp.ph.ppps.ptt.......................p.pthhts..pt..........t......h.s.sss.hhs......p..s.....t..TPpt.tpph.........................................ttt........h..oPs...s.p.st.t.t.......................................................................asp...RtstGpllpshs.s..t.......ps............hss.s.sh.....hc.l.hst..-...h.ph..t...a+.Mh.+L.-t.p-lLsspI-phsp.l.pppaphp...tass....u............................................................................................................................	0	52	97	146
+8253	PF08421	Methyltransf_13		Putative zinc binding domain	Wuster A	anon	Pfam-B_2038 (release 18.0)	Domain	This domain is found at the N-terminus of bacterial methyltransferases and contains four conserved cysteines suggesting a potential zinc binding domain.	20.90	20.90	21.10	21.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.95	0.72	-4.48	27	438	2009-01-15 18:05:59	2005-08-18 15:41:25	6	9	358	10	145	436	1072	61.50	34	14.89	CHANGED	CRlCssstlpsllDLGtpPlsssFlss..ttscspshaPLclhhC..psCtLVQLpchlssphhFs	.................CRhCust...h.pshlDLGhsPh.ss.uFlss..tph.s...p..E.s....haPLclhlC......psChLVQLpchhsscplFt...........	0	48	101	122
+8255	PF08423	Rad51		Rad51	Mistry J, Wood V	anon	Pfam-B_684 (release 17.0)	Domain	Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.52	0.70	-5.48	20	2467	2012-10-05 12:31:09	2005-08-18 16:12:14	6	29	887	65	1071	8769	2265	183.50	30	69.83	CHANGED	shGFpTAo-htppRpcllpITTGS+pLDpLL.GGGIETGSITElFGEFRTGKTQLCHTLsVTCQLPl-hGGGEGKshYIDTEGTFRPERllsIAERaGLDspsVL-NlAYARAYNs-HQhpLLtpAuuhMuEu+auLLIVDSsTALYRTDaSGRGELusRQ.+Lu+FLRsLp+LADEFslAVllTNQVlApVDGu.uhFs.uDsKKPIGGpIlAHASTTRLhLRKG+G-pRlCKIYDSPsLPEuEssFuIsppGItDsc	...............................................................................................................hc.t.hh........t..........u.................Gh..........................lsE.................h..h.................G...ts...GKoQl....s.hp.h.s..ls.s......p.....ls.....................t...........t.....G.............h.......t.....u..........t..sha..l.................D.T..........E...s.s.....F......p....s...............p..R.....l........t...........h.................s................p...............t..............................t................................p..........................p..........t.............h........L........p......p...........l............h......h...s......+.......s.............h.....s..........................p........c......p....h............t........l.......l.................t....h......t........t......h......h.............s......c..........p...........t.......h......p....L......l..ll.DSl.....su...h.....a.....R...s......-.........a.............s.........u........c.......s........p...............l........u......t............R.....p.....p.....p......L.....s.....p.....h....h............p..t..L..p.l.u...c...p...a...s...h...A...l.h.l.sNQ.............h.......t..............t..........t....................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	328	556	830
+8256	PF08424	NRDE-2	DUF1740;	NRDE-2, necessary for RNA interference	Mistry J, Wood V	anon	Pfam-B_21376 (release 17.0)	Family	This is a family of eukaryotic proteins.  Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids, and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei, and in plants and fungi small interfering (si)RNAs associate with nascent transcripts and direct chromatin and/or DNA modifications. This family protein, NRDE-2, is required for small interfering (si)RNA-mediated silencing in nuclei. NRDE-2 associates with the Argonaute protein NRDE-3 within nuclei and is recruited by NRDE-3/siRNA complexes to nascent transcripts that have been targeted by RNA interference, RNAi, the process whereby double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA [1].	26.60	26.60	26.60	26.60	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.99	0.70	-5.55	23	285	2009-01-15 18:05:59	2005-08-18 16:51:24	5	6	205	0	211	292	3	263.90	22	29.68	CHANGED	lpp+stELs+plccsPpDlctWlchlcaQ-plhp.tpp............psppptls-hKLSlhE+ALcp..s...s..sc-cLllthLctssclW.ssccltp+....Wppllpp...........sss..phsLWhpYLcacQup.........FusFohsclhpsahcslctLpsuhsp...................phppshltlFlphshFl+puGasEhAlulaQAhlEhshapPpplptp...........ptlptFppFW-S.tssRlGEssApGWpph.pt..ps.ps..sttp..ssps.........................hap..........uWtpsE...................ppRpspsthPsRs.........s-st--DP.RsllhsDlpshLhhl.s...tpsphpLlpshLtahtlP.h.p.ss	...........................tc..phpptlpppPpshphWhthhtaQc..phht..t..................................ptpht.hh-hKlulh-+Alpt.......p..................s...sp.pLhl..t......hhc...s..t...ph........h...ps.....pt....lhpc...................Wpphl....................pst.......thtLW.pal.hppsp..........hspashsphhpha.pslpthtthtpt.....................................thp..hh.lhhphshahppuGa.....EhuhuhhQuhl-hshhtPt.h.t....................t.ht.ht..FW-s.t.sRhG............-.su.GWt........t..............................t.......................................................................................................hap.Wht.E........................................................ptpt......ttthhPh+s.................sp.tppDs...R...lhhsDlt..Lh.h.p.....t.t...Lh..hh.hhth.......s...........................................................	0	77	117	173
+8258	PF08426	ICE2		ICE2	Mistry J, Wood V	anon	manual	Family	ICE2 is a fungal ER protein which has been shown to play an important role in forming/maintaining the cortical ER [1].  It has also bee identified as a protein which is necessary for nuclear inner membrane targeting [2].	25.00	25.00	32.80	27.30	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.45	0.70	-5.87	16	140	2009-01-15 18:05:59	2005-08-18 17:08:01	5	2	127	0	104	136	0	388.20	36	93.55	CHANGED	lRshhushYLhlllloIPlAFDVGGlsCGLuFSlTLFshYFlhoTl+llst+pp...ahhhsSllYY..sQahlIPoLLhhFLShass-p.tt................................p..s...hhhhhpthVc.....sWchhLspSTPlFTLLEGFCoLLlIQAlGpss+WLshc..+SDoWlIhSLlsSGulITuohYaLYRIYshP.aplshhsAoLLGhsLohshsLGhaGIlSG+GShlESSLhFAYlV+CIYEIFPchupsAopslhphhppsh.tshpsplP...................................lPP.....................Ihssloplh+hlo.olPsShpslaphhh.hAhpoloPulllsLsaRIhVFYuATRIIPulpcsushs..........................................................................pcssspllphlYhYSPCIlIAVYTHLlLQYpGpLts-LslW.....ha.....................p.phllcuWpFWNWlNlhsTllLYAsELhuu	................................................................................phh.ushaLh.hlloIPlAFDVGGhpCGLuaSloLhhhYFhhohl+lhs.cpu.......hhh..h..s..sl..lhh..sQahlIPuLLhh.LstFSsDs.ss.............................................................t.h.......ppp.....sh..ahahhptllp.....sWchlLpaSoPlFpLhEGFsoLLlIQAsGQhsR.WL..ssc..pS-..oW.hIs.LlhSuulIouul.YaLaRlh.hP..tlosh.sAsLlGsslTssshLshaGIsSu+GsslESS...LLFAYlVhClYpIhschtsos.s.tth......s...spp.phP.................................................slPP.....................................lIhss....h.o.slh+hlo.....sLPs.lpshhphlh.hAhpsloPullIsLsYRlhVhYuATRIIPAlpcsus.ps..p.sp....tp....................................................................................................................................................................................................................................................pcs.ssp.hlthL.aaSPsILIAVYTpLlh.Qa.up..t.t.shh.........h.......................phsssuhshWpWhNlhsThhLYAsELhh.s......................	0	26	58	89
+8259	PF08427	DUF1741		Domain of unknown function (DUF1741)	Mistry J, Wood V	anon	Pfam-B_35314 (release 17.0)	Domain	This is a eukaryotic domain of unknown function.	20.30	20.30	21.80	21.60	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.51	0.70	-4.90	13	205	2009-01-15 18:05:59	2005-08-18 17:17:45	5	4	175	0	150	199	1	213.60	36	35.35	CHANGED	Ph.sspsRsLuTslLDlhl-sIsaNL+++LssslYslsluIlhRlloYhscs+lRLsYHWpELWpsLLoLl+FL..sohso-Lpsp.....splppLsppllNllAhhlosGDoFLPossuYD-LFYKllcsupllscF+shhtppsp.s......ss..h....................................hsulssLluVspHFpshlh............t.sups.........ppppLoscpVpclIKpsY-TLolphp-uLstap+acEus.hcshhK+hsRssVsDsRthl	...................................s.ssRsLssslLDlhl-hIspphh.+chshcLYhhCltllhRlLsY.p.+s.+lR..L...p.Y.pWpELWpuL.lsLl+FL.......ho.p.ss..Lhsp.......sIh.sLshplVNLhshhlohGDTFLPoPsSYD-L...........aYcllchtplhsphhshhhhh...spss...........s.th....................................hpulsslhsl.sHapshlt...........................t...t.p......................ph.pplo.ppVhpll+psY..-TLolp.hp-uLstaE+apEts..tshhKchsRshstss+.........................................................................................................................	0	49	76	118
+8260	PF08428	Rib		Rib/alpha-like repeat	Fenech M	anon	Pfam-B_3139 (release 18.0)	Repeat	The region featured in this family is found repeated in a number of bacterial surface proteins, such as Rib (Swiss:P72362) and alpha (Swiss:Q02192). These are expressed by group B streptococci, and Rib is thought to confer protective immunity.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.22	0.72	-4.21	16	1574	2012-10-03 16:25:20	2005-08-18 17:26:22	5	133	326	0	165	1657	10	66.80	33	17.85	CHANGED	loscsGt....sPDss-GIpNhscLPcGTp...Y.......sWcs...........sPDsosPGcKsusVVVTYPDGSpD-VsVsVpVss	.....................................................ps..ut.......pP.s.sp.-.sI.......p..N.........h......ss...L.....P.....c.....G....Tp.........h.................sacs.............................s.DT.s......s.s.G.c.p.s......up.VsVTYPD..GS...p.....-......p......V...s...V.sVpVh.....................	0	21	54	149
+8261	PF08429	PLU-1		PLU-1-like protein	Fenech M	anon	Pfam-B_4023 (release 18.0)	Family	Sequences in this family bear similarity to the central region of PLU-1 (Swiss:Q9Y3Q5). This is a nuclear protein that may have a role in DNA-binding and transcription, and is closely associated with the malignant phenotype of breast cancer [1]. This region is found in various other Jumonji/ARID domain-containing proteins (see Pfam:PF02373, Pfam:PF01388).	24.30	24.30	25.50	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.98	0.70	-5.55	30	546	2009-01-15 18:05:59	2005-08-18 18:47:40	6	64	236	0	309	488	4	291.60	26	21.73	CHANGED	-sWtp+scchLc...pss+ssLcsL+sLlsEuEchtas...................s-L.ppL+shVppAcphlcpAppllspKppsR.......p+stts.............................p...sp..hslpplppLlcphpsLshsssp.lspLcchhppl-pFppcApphLpp......sshshtclcpLl-pGpshsl-lPElstLcphlcpt+Wh-cspcths.h..............hol......c-lccLl-.pGtpls...spspchhtcLpchlshu-pWEc+Acch.....................Ls.........t.p.hshspLpulhppu..ps...........lPlslssltpLcshLp+u+p......atpplpsl..p...........sspphPphc-lcslhtpucsLssph.pphppLE.....pplpptpsWp-+us+hFhptNush.slLp	.............................................................ptWhtphpthLp....tt+.sL.ph+sLhp-uc..p..h.as..............................spL.ppLpthhpcscphsp.utthlst.ppppp...........p.............................................................................................t..hslpc...lpthl.pp.h...sLsh.sh.sp.htt.lcphhpplcpappcupphLtp.......ptss...........t........p........lp............pLl-.upp.......h...sl.-...l.PplttLp...p.t.l.p.p.t.+.Whccsppthttst........................................hoL......p.hcpLlc...tGhtls......ssscc.ths.....c........Lp...c.lLshucpW-cKAc.h...............................................................Lp................p.p.hshspL.csllpps..pp.............................................l.P.s.l.....ss.ht....sLcphlp+A+t........................Whtplctl....p.................................stpphshhcp.LptLh.ttu..c..s...lssth.pth..plE............tltpscsWpcp....stphFhptsu.h.plLp.............................................................................................................................................	0	82	140	232
+8262	PF08430	Fork_head_N		Forkhead N-terminal region	Fenech M	anon	Pfam-B_3191 (release 18.0)	Family	The region described in this family is found towards the N-terminus of various eukaryotic fork head/HNF-3-related transcription factors (which contain the Pfam:PF00250 domain). These proteins play key roles in embryogenesis, maintenance of differentiated cell states, and tumorigenesis [1].	21.60	21.60	21.60	21.80	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.63	0.71	-3.77	29	224	2009-01-15 18:05:59	2005-08-19 10:58:52	7	3	94	0	100	197	0	126.60	31	30.04	CHANGED	shYs-s.ppsYSss..s...........sMNoMsshhshssh....ts.............................s.sM.uhss....suhus.sshsuMssGhsuhhs......s.huhsshus.shussu.hus.hust.sss..hssluP..tshsts.s......s..thpR.....ssKsYRRSYTHA	..........................................hY.ts..psYos...s........................sMNs...Mso.hhshssh.........s...........................shsM.uhhs......suhus....sh.suMusussuhh............uhhuhsuhus...slusus..hus.hust.sus...hsuluP..tshssh.s.....s.utlptsR......ssKTYRRSYTHA........	0	17	26	59
+8264	PF08432	Vfa1	DUF1742;	AAA-ATPase Vps4-associated protein 1	Mistry J, Wood V	anon	manual	Family	Vps Four-Associated 1, Vfa1, in yeast, is an endosomal protein that interacts with the AAA-ATPase Vps4. It would seem to be involved in regulating the trafficking of other proteins to the endocytic vacuole [1].  There is a CCCH zinc finger at the N-terminus.	21.30	21.30	21.30	21.60	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.55	0.71	-4.26	24	142	2009-11-11 09:10:55	2005-08-19 15:36:58	5	2	129	0	107	136	1	164.20	33	88.68	CHANGED	NhYphR+VAsssuKuChICaKPoooVLlossst.................DFFYlCssHLpDc.pFso....Plhss.chttsctKpctlpcclccl...KK-hEpcpphhpch.tph..............Kcs-cpK-cc................sspcs.-ppccpcpcptcpchpslppshst.tsphsp...ps+hasLcp.............shaptRlcphpptch......tccpp......pclpp.sshFPslPp	..........................NhYphR+VAppsu+sChICaKPoooVLl..s...ssst......................DaFY.sC..HLp..Dp.tFss...........Phhsp...ph.t..st.......tctcthpc-l-+l...cp..-hE....p+ppt.tpct.ppt...............ccpcppK-pc................ppppp.....sppspp...pp.cpppcphpp..hppphst..........sphsp.......psRhapLpp..................shap.Rlpch+....phph......s+cpt............pcl.tp..thFPSsPp...............................................	0	25	55	86
+8265	PF08433	KTI12		Chromatin associated protein KTI12 	Mistry J, Wood V	anon	Pfam-B_11625 (release 17.0)	Family	This is a family of chromatin associated proteins which interact with the Elongator complex, a component of the elongating form of RNA polymerase II [1].  The Elongator complex has histone acetyltransferase activity.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.68	0.70	-5.19	21	408	2012-10-05 12:31:09	2005-08-22 14:09:07	5	14	303	13	286	1745	907	262.30	25	83.50	CHANGED	MPLlllTGhPsSGKoThAcpLtphhpc............pshsVhlls.D-slt.....hs+cs..Yt.cSppEKthRuplhSsVcRsLS+s.slVIlDuhNYIKGaRYpLaChAKsspTsaCllashss.................h-hshpaN.....pp+sps.........................................................ass-ll-pLh.RaEcPsspsRWDpPLFolh......sccshsh......................--Ihpsl................hppptLpPNpuThspPh.usssaLpcLDppTppllstIhpt.ppssssstlp..............hs.ssp..lphsts...holspLpRlRRpFlshs+........psh-h-+lhshFl-aLN	.................................Ms.Ll.l.hsGhPsSGKo.phut..p..l..t..p..h...hpt..............................................................t.h....p.l..h...h.ls...ppsht.......................ht.pps.......a............t..........s.s............t..........t..E....+.....h....R......u...............h....h....u.....t....l........p......R.......t......l.........s.................c........p.....s..........l.V....I........l.D..u....h..N.....Y.I..K...G..aR......Y....p..L.a.C...h.u..........+..t...h..p......s..s..h....C.h.......l..a.s...s.ss.........................................h-ps.hphN.............ppR...t..p.t......................................................................................................................................................a..s..t...-.h...hc...p...Lh...h..R.......a......E...p.P...s.s.p.s.R..WDp...PLhsl...........sptp....s..h...............................................................................................................ppl.h.ps.l.........................................................................hp.t.t............s..pt.u..T.......t.t....sh.......s.......s..s.......shLa.p..lDp.tTppllstlhp.....t..t.p..t........h..s..h...........................................................h.t.................hsh.pLpch++palth.p..................t......ph...Fhthl..................................................................................................................................................................	0	108	158	233
+8266	PF08434	CLCA_N		Calcium-activated chloride channel	Wuster A	anon	Pfam-B_3091 (release 18.0)	Family	The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells [1] and has four or five putative transmembrane regions.  Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors [2].  The domain described here is found at the N-terminus of CLCAs.	20.30	20.30	21.20	20.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.70	0.70	-5.16	13	295	2009-01-15 18:05:59	2005-08-22 15:35:17	6	15	48	0	190	313	0	228.60	40	29.90	CHANGED	MushpsslF.lLlLaLLpus.ssSL......lpLNNNGYEGIVIAIsPsVPEDEpLIppIK-MVTcASsYLFEATc+RFYF+NVuILIPtoWKu+scYh+PKpEoYcpADVlVAssshttsD-PYThQaGpCGEKGcYIHFTPDFLLsccl.spYGPpGRlFVHEWAHLRWGVFDEYNsDcPFYlutppcIcATRCSssITGpshVhpCQGGSClo.+pC+hDppTGLYEcsCpFlPc+sQotKASIMFMQulDSVVEFCsEKsHNpEAPNL	.....................................................hh.hhhl.hll..s.....tssh........lpLpsNGY-slllAIsPs..VPE....D..p...p..lIppIK.....-MlTpASsYLFpATcpRhY.F+sVsILIP...tTWp...s...............p.s.........p.Yt.hs....+..p.E.o........Y...cp...ADVlV....ss..s.t.........hs.D..c.PY......ThQas..tC.G-pGcaIHhTPsFlh.....s....c.....ph....t.Y..G....s.p......G+lhVHEWAHLRWGVFDE..Y...s...p....-.......p.......P........F.Y..h.s.t....p...s....pl.....csT.R........CSstIsG...l..tsp..tssC......p.......Cphs....ot.l.a.c.ttCpF.hPp....p......Q..s.t....p..uSIMF......h...Q...s.lsSVs-FCs.......p.......p.....s.......HNp-APs...............................................	0	89	93	121
+8267	PF08435	Calici_coat_C	Calici_coat_N; 	Calicivirus coat protein C-terminal	Wuster A	anon	Pfam-B_108 (release 18.0)	Family	This is the calicivirus coat protein (Pfam:PF00915) C-terminal region.	25.00	25.00	27.10	30.20	20.80	19.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.40	0.70	-5.06	29	2058	2009-01-15 18:05:59	2005-08-22 15:40:16	6	5	1840	102	0	1400	0	178.20	60	47.19	CHANGED	LTpLDGoPacPs-c.PAPlGhPDFuuphasVhsp.csss........suspucpshlsTssspFsP+LGslphso.s.....sD.hhsstssphoPsulssst...phs.WslPcYuusLs.sspLAPuVsPshsGEplLFFhSplPhs.uG..hssshlsCLLPQEaVpHFhpEpAPupu-lALl+YVNPDTGRsLFEuKLappGFlTl..ssoGssPhslPsNGhFcFsSWVspFYpLtPhGTuuutRR	...............................................................................................................s.shssaDPsE-hPAPLGsPDF.Gpl.GlhoQ.pspt........ssTRuHcAhl.Ts..s.spFsPKLGp.....l.h..sops.....sD..hpstpss+FTP..lGlh.s.....tt.....c.pQWslPpYsut......shpLAPslsP.hsGE.lLhFto.h......ss...hss.........lsCLlPQEWVQHFYQEuA....PuQ.S-VALLRaVNPDTGRVLFEsKLHKsGalTV..ApoGpps.lVlPPNGYFRF-SWVNpFYTLAPhGsG.................	0	0	0	0
+8268	PF08436	DXP_redisom_C		1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal	Wuster A	anon	Pfam-B_445 (release 18.0)	Family	This domain is found to the C-terminus of Pfam:PF02670 domains in bacterial and plant 1-deoxy-D-xylulose 5-phosphate reductoisomerases which catalyse the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH [1].	20.80	20.80	21.10	20.90	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.10	88	3400	2012-10-10 17:06:42	2005-08-22 15:49:37	7	8	3281	79	827	2645	1733	87.00	58	22.25	CHANGED	llPVDSEHsAIFQsLpupstpp......lc+llLTASGGPFRshshcpLpsVTsppALpHPsWsMGtKITIDSAThhNKGLElIEApaLF	...........lLPVDSEHsAIFQsL...........s......p....t....p...pp................lp+llLTASGGPFRsp.s.hccLtsV.......T.......s.......cp....AlpHPNWuMGpKIolDSATMMNKGLElIEA+aLF..........	0	290	560	711
+8269	PF08437	Glyco_transf_8C	Glyco_transf_8N;	Glycosyl transferase family 8 C-terminal	Wuster A	anon	Pfam-B_3038 (release 18.0)	Family	This domain is found at the C-terminus of the Pfam: PF01501 domain in bacterial glucosyltransferase and galactosyltransferase proteins.	19.10	19.10	19.70	19.50	18.10	18.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.70	0.72	-3.95	14	973	2009-01-15 18:05:59	2005-08-22 15:50:24	5	2	442	0	23	344	0	56.50	39	17.19	CHANGED	YPsspYFhpAhpsSPWpchsLhcAsstpph+hphKHhhtpt+YlsGlhshltYhhcK	.....YPsupYFhpA+psSPWcchsh.h.cs.ssppph+hphKHhhtQp+YhsGlhshltYhhcK..............	1	2	6	15
+8270	PF08438	MMR_HSR1_C		GTPase of unknown function C-terminal	Wuster A	anon	Pfam-B_4095 (release 18.0)	Family	This domain is found at the C-terminus of Pfam:PF01926 in archaeal and eukaryotic GTP-binding proteins. The C-terminal domain of the GTP-binding proteins is necessary for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotides.	23.30	23.30	23.60	31.10	22.80	23.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.48	0.72	-3.82	93	341	2009-01-15 18:05:59	2005-08-22 15:51:20	5	8	303	1	227	327	110	110.50	40	25.54	CHANGED	AANKsD.h.s..uccNlc+lpc..............llPsSAtuELuLR+AscsGhIc..YtPGDpcFp...lss-s....................l.scpQcpuL-tI+c.llpcaGu.............TGVQpslspAVa-lLshIsVYPVcc	.....................................................................AhNKhD.hss...........A-cNlp+ltc............ph..ssptlVssSAhuElhLR+hs+pGhIc..YhsGs.-Fp...hsp-s......................l.s-cpcptLEpl+-.V..Lh+aGo................TGVppsLspAs.-lLshlsVYPVcs.........	0	60	135	193
+8271	PF08439	Peptidase_M3_N		Oligopeptidase F	Wuster A	anon	Pfam-B_679 (release 18.0)	Family	This domain is found to the N-terminus of the Pfam:PF01432 domain in bacterial and archaeal proteins including Oligoendopeptidase F.  An example of this protein is Lactococcus lactis PepF [1].	20.70	20.70	20.80	21.40	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.05	0.72	-3.93	182	3235	2009-01-15 18:05:59	2005-08-22 15:52:47	5	3	2039	3	529	2248	391	68.60	25	11.49	CHANGED	Elhpls-pplpphlp.pps...pLptYpahLccl.hcp+sHhLStcpEplLuph.ssshsuhsplashls.uclpF	........................Elhpls-cplpphlp.tp.......cLptYpahlc.pl.hpp+sHhLotcpEclLuph.s-shsusschashhs.uDlpF........................	0	204	361	452
+8272	PF08440	Poty_PP		Potyviridae polyprotein	Wuster A	anon	Pfam-B_237 (release 18.0)	Family	This domain is found in polyproteins of the viral Potyviridae taxon.	23.40	23.40	23.70	23.60	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.58	0.70	-5.33	63	1068	2009-01-15 18:05:59	2005-08-22 15:54:46	5	30	151	0	0	1152	0	222.90	45	9.43	CHANGED	AAFLCFsYGLPV.hTpsVoTulLupCTlcQARTMhpFELoPFahschV+aDGoMHPpIHclLKpaKLR-S-lhLschAIPhpssspWhosp......-Yp+lGsplph.scsl+IPFhs+slP-claEclWcslpcaKs-usFu+lo.SssAsKlAYTLpTDstuIsRTlslI-pLlpcEppKppaFcolsussssutsFSLsu...Iss.slRsRYh+DaopcNIphLppu+uQLhEFpshshchps.ph.........lpsaGsLpsVpaQocpp...lu+tLpL+G+W......stslhspD	......AAhhsFsYsLPV.hTpsVSTsllupsTV+Qs+sh.tFELoPFah.phlpaDGoMHP.lHclLKpaKLR-u.h.Lsc.uIP.phsstWhosp......-YpR.......Gh.plph...cpl+lPFhhpsIPpcLap.lWcslhp.a.KssssFsplp.usshsKlu.YTLpTD..uI.RTlhll-pLltpEhhKpp.Fcshhspss.u..FSl.s...lss.sh+t+hh+DaTtcNIthLpts+uQLhEFpshphshsp.ph..........hpcaGuL.psVaHQspss...huKhLpLKG+WsKoLls+D...........................................	0	0	0	0
+8273	PF08441	Integrin_alpha2		Integrin alpha	Wuster A	anon	Pfam-B_609 (release 18.0)	Family	This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of Pfam:PF01839 repeats and to the N-terminus of the Pfam:PF00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.	33.00	33.00	33.40	33.20	32.90	32.70	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-12.85	0.70	-5.64	97	1499	2012-10-03 16:25:20	2005-08-23 09:52:25	7	51	113	50	666	1224	1	389.40	20	41.35	CHANGED	uRPVlpl.psslphpPpp..lshpppp....Ct.s.......hsC..hslpsChphpupsh.......stplslshslplD.....ptpthpRshF..................tspppshptphhhhsptpthCp.phphal.p...shcDhloPIslplsasL................t.ttshsslp..PlL.s.t..psshhppplsFt+s...........................................................................................................................................................CGsDs..lC.sDLpL.ssphstp..p............................hllG.ss..pplslplslpN..........pGE.sAYpspLhlph.PssLpatplt..................pt.tp..sC....stppssp......hlsCsl..GsPhhp..ssplphplhasssphst..........tpslphplps...posspps....pssshphplslthtsp.......lpl.pGsspPsphh........................p..spcchGs...tlp.apaplpNpGss...slspsplplphPhphpss........hLlahhplt...............t....C.................sttthsshpl................................ptst.ssspppphphpppphhtp.ttt......................................s.ps....pChplpC	.............................................................................................................................................................................................uRPVlpl...ps...slp.h.pPp..........lshpthp.......Ct.t..............s....hplphChphpspsh...........s.phsl......p.hp.lphD......ttth.tRshF...................spptp.h.ttp..hh..hht.ttp......C..p..pht...hhl...p...............shcD.....hls.....P....I...sl...plsasL......................................p..slt.....PlLs.......t...p..t.........h...ptp..h....a.....p.s.........................................C..GpDp..hC.ssL.pl..psp...hstpp............................hhls.sp..pplslplslpN..........pG.E.sAYpsplhlph.P..s.lpattl............................h..pC.....p.tpps....................h.C.pl..G.p..P.....hhp...ssph..phtlhas.s..s..th.p...............t..pplphpl..p......h......po...p.....s....p..pp..................pps.h..p.hp.h.l...hhts.t..............l.l...pu..spssphh.......................p...........p.pshGs............lp..a.a..p.l...........t...................N....G.....sls.th...lplthPht.h....ps....t..............lla.hhph...........................t.hp..Cp.................t...p..th...................................................................................................................................................................................................................................................................................................................	0	114	162	355
+8274	PF08442	ATP-grasp_2		ATP-grasp domain	Bateman A	anon	Bateman A	Domain	\N	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.14	0.71	-4.94	22	4398	2012-10-10 13:17:03	2005-08-23 14:07:01	5	18	3546	33	1434	3767	3414	194.30	40	47.81	CHANGED	sLHEYQuKclhp+aGlsVPpGhVAposE-ApchApcluspshVlKAQVhsGGRGKA.........GGV+lspos-EstchAcchLGppLhThQTs.tGphVpcVhlp-tssIp+EhYlulllDRssppslllASscGGh-IEEVAtcsPEtIhKhslDsthGlpsapARclAhphGhps.c.hppsschlhpLYclFhcpDAohlEINPLVh	............................................................................slHEYQu.K..p.l.h.tp.......a.........G...l.s.ls.pG......hs...s.....to..s..c......EA..............p....s.....A....p....c......l........u...............s....s.........s............h..V..VK...u...Q.l.+..A.GG.RG.Ku.................................GGVKl.s..c....o..h..-.-s.c.t...h..A.pp....h.L..G..p.pL...l....T.h.QT........s.s..p......Gp.....V..ppl...h....l.E..p...s.s........s....I.........t.......+.....E...hYluh.ll.D..R...usp.p..sshhuSs..E.GGh..-.IE...c.VAp...c...s...P.-t.I..h.Kh.s........l.D...P...h....s.G.h.p.s...h..p..u.R.c..l.A.h.p.l....G..l.s..s...p......h...pphschhhsLap.hF..h.-..p..D.h.sl..l..E..INPLl.............................................................................................................................................................	0	451	852	1189
+8275	PF08443	RimK		RimK-like ATP-grasp domain	Bateman A	anon	Bateman A	Domain	This ATP-grasp domain is found in the ribosomal S6 modification enzyme RimK [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.07	0.71	-4.82	5	2606	2012-10-10 13:17:03	2005-08-23 14:07:23	6	34	1803	4	917	10880	6158	177.30	31	43.97	CHANGED	AcDKh+ShpLLAKps........IslPsouLuau.-cApchIEclt...uaPlVlKslaGSpGltVhLAcccQuLcull-uh+.hsssI....LlQEFIccuss...cDIRslVVGsEVVuAlcRhuc-G-FRoNLaRGGsuEshslosEEcEIAIKAucAhuLslsGVD.Ilcoc+GLLVhEVNuSPGLcshp+soGINIAtKll-aI	............................................................................................................................................psKhhshplL..tpp.u.................l.s...h......P....h....T....h....h.....s.........t.....s..................c.....s....h....t....c....h...l..c.h.l..........uh.P...lV.lK.....h......h......p......G......o.....p.......G...h.....G....V...h......l.....s......c...s...........p.......p...........s........h.....p.......s......l.....l......c......s.......h.......h......t......h......p......s...t...l...........................ll.Q..E...al.....p..p..s..t.s.............tDl...R.....s..h..V.........l....G..........s...........c.........l........l.........u......A.........h........p........R......p........u........t......c.......G...........c.......a..........+........s........N.......h......c........p...........G.........G....s........s.............p..........h.........h.........p..............l.........o........s..........p........t.....c.....c......l........A...........l.....+........A.....u....c.......s......h.......G.....l.......s......l........s.....G.........V.....D.....l........l.......c.................s.......s.......c.......G........s.......h.....V.h.EV.N..u...s.....P..u.....h..c.u...h...p....t.s.s..s...h...s.l.u.t..hht........................................................................................................................................	0	288	540	763
+8276	PF08444	Gly_acyl_tr_C		Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region	Fenech M, Moxon SJ	anon	Pfam-B_7828 (release 9.0)	Family	This family features the C-terminal region of several mammalian specific aralkyl acyl-CoA:amino acid N-acyltransferase (glycine N-acyltransferase) proteins EC:2.3.1.13.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.01	0.72	-3.97	8	176	2012-10-02 22:59:21	2005-08-23 15:35:18	5	3	37	0	93	173	2	87.10	38	30.37	CHANGED	hClLGPEGTPVSWsLMDQTGElRMuGTLPcYRtQGLls+VhappsptLcKhGFPhYsHVDcsNpshQ+MStsLsHlshPCsWNQWNCsP	.......................hClLsPEGsPVSWslMDQouEhpMuYTlP-YRp.pGhhphlhhp.hsptLpppGa.P.h.YspVtcsNptsh+hhpslta..h...h.P...Cp.WppW.hsP..............	0	7	9	26
+8277	PF08445	FR47		FR47-like protein	Fenech M	anon	Pfam-B_71946 (release 17.0)	Family	The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47 (Swiss:Q9VR51). This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.60	0.72	-4.23	9	870	2012-10-02 22:59:21	2005-08-23 15:35:46	5	14	549	3	377	18220	2313	82.70	21	31.53	CHANGED	slGlhct..chsphsuWhl+..s.Gtluulpshsca+p+GLGshLspuluctIsp.cGpsshshlsssNssupplac+LGFphh...pshal	...............................................................................h.................h....s.......p.....l......s......s....l......h...s...h.s.c..aR...t+..G..h....u....s.t....l....s....t........s....l....s.....p..........p...............l....h.........p......p...........G.....c.......p...........s.......h.......l...h.....s...s....s....s..N...s.......s...u...t....p..l..Y.p..+..l.GFpth...........hhh............................................	0	141	246	325
+8278	PF08446	PAS_2		PAS fold	Bateman A	anon	Pfam-B_437 (Release 18.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	21.40	14.00	21.40	14.80	21.30	13.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.44	0.72	-3.60	41	1308	2012-10-04 01:10:46	2005-08-24 15:19:37	6	52	760	31	297	1415	19	101.80	37	12.43	CHANGED	shhptIQpsGhIQPaGslLAl.-Es....shplluhS-Nss-hLsls................spp........................lGpcl+sLhsssusssLccAhsss-lohlNPlhlp.s+s...su+sFhAllHR....h-..sslll-LEPs	..........s..p.Iphs.shIQPaGshlAl...-...-..t.........s.hpllt.h.SENs.p.hLshs................tt.............................................lG.pslc...s...L.h...s..s.s..s......s.h...t.L.p..p....A.h.s.t....t..c...l....s....h....hs.Pl...h.hp....scs.........ouK...P..F..aAIlHR...........hs.....sulllDhEPs..........................................................	0	79	167	233
+8279	PF08447	PAS_3		PAS fold	Bateman A	anon	Pfam-B_64 (Release 18.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.00	0.72	-3.89	122	12998	2012-10-04 01:10:46	2005-08-24 15:19:44	6	2702	2306	12	5490	23426	1576	87.10	19	13.27	CHANGED	hlhhss.ph..tclhGass.p-h..hst...hhphlHP-Dhtthhpshpp......tht.pst.hpt.-aRhhp.psGphh...Wlpspspsht.spsGpshphhGsh	.......................................h..hhst..ph....hpl..h.G...h...s....p....c......h..................s.................................h..........h..p..h.....l...H...P...-..D......h...p...t...s..t..p...s.h.......pp.............thp..ps....p...s........a..p.......h....c......a..R...l...h...........p....p..........c...G........p...h.p.........Wlp.sp.u.psh..h...s...pp.G.p..h.thhG.......................................	0	1661	3542	4558
+8280	PF08448	PAS_4		PAS fold	Bateman A	anon	Pfam-B_493 (Release 18.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	23.10	23.10	23.10	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.00	0.72	-4.02	49	13956	2012-10-04 01:10:46	2005-08-24 15:20:11	5	2601	2465	26	5614	38008	2799	109.70	16	17.36	CHANGED	hcshssslhhh....Dt-hphhhsNts......htp.hhthsspphhGcsht..-..hhst.......ttsphppthpcshpsppshphhthhth.......ssp.chhphph..hPlhs.pGp.hhuhhhhspDlTpppp	......................................................................pthss.slh...hh.......D...t.....c......t.....p...h...h..h..s..Nps...................htp....h.....h.....u......h......s.....t......p........p....h......l.......G...c.s.hh.............-.......l.h...s.tt..........................t.t..t....h.....t....p....t......h......p.......p......s.......h........p........s........t.....p......s......h.....p...h...p...t..h.hhh........................ss.p..t...p...h..h...p..h..ph............hP...l.....h.........s.......t.......p.........G.........p....h..........h.......u...l.l..s.h..spDlTcpt.............................................................................	0	1870	3885	4919
+8281	PF08449	UAA		UAA transporter family	Bateman A	anon	Pfam-B_606 (release 18.0)	Family	This family includes transporters with a specificity for UDP-N-acetylglucosamine [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.61	0.70	-5.50	23	1443	2012-10-02 19:55:49	2005-08-25 11:28:56	6	22	332	0	997	3957	210	274.70	19	77.88	CHANGED	hlhshuGlasuhhs.ulh.Ehlhptp.us..............uthlTFsQhlhhshhuhlhthhhp............htppphPh+pYhlhshhhhhssshsNtuLpa.lshPspllh+SuphIssMlhGhll..hpK+YshhcYhushhlolGlhlholhsupsssspptpt.p...............GlhlLshuLhhsuhhushQEpla+pYstss.........pEhlFYophhuhshhhlhhh......pshhhpuhthhh......................phPp.hhhaLlh.slspals.phVahhhsphuuLTsollsTlRKhlSlllSllhFspshohtphlGshlVFhGhhlhshstpptp	.........................................................................................................................................................................h......h..h........s...h.h.....c..h..l....hp....t...........................................s.hls..h....h.p...h..h.....h....h..h..h.....h..u.h..h..h.h....h.ht........................................................tt.hs....h.......h......t....a.....h....h.....h....u....h........h....h.....h....h....s.........h....h....s....p....t......u...L....p....a.....l.s...h...Ps................h...lh..Ku..sp..h.lsl.....h.l.h.u.hll.............ht...+..c..Ys.h.h.c...h.h.....s.sh.....h.ls.hGlhl........h.....s...h..t.ss....p.t...t.t.t....t.t.t.t........................................................................G.hh.h.l..h.h...s..l...h...h....s..u.........h....h.......sh..h.p.......-.p........h..h...p...t...h....t...h..p.s..........................hp.h.h..h.h..s...s....h....h....u..h........hh..h.h...h.h..hh..........................s.t.h..h..p..s..h..t..h.h.....................................................................ph.st....hh.......h.......l....h...h....h....s...h....s..........s....h..h......u........h....h...l......h...h....h....h....t.....h......u......u.l.s.h.shl.....h.s......h......R.K.h....ho.h.l.h.S.........h..l....h....a........s..p.....s...h....o.h..h..t.h..h..uhh.l.lFhuhhh.sh......t......................................................................................................................................................................	0	376	570	831
+8282	PF08450	SGL		SMP-30/Gluconolaconase/LRE-like region	Finn RD, Fenech M	anon	Pfam-B_3630 (release 7.0)	Family	This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30, Swiss:Q15493), gluconolactonase (Swiss:Q01578) and luciferin-regenerating enzyme (LRE, Swiss:Q86DU5). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 (Swiss:P52430) and LRE [1].	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.67	0.70	-5.00	50	3454	2012-10-05 17:30:43	2005-08-26 09:32:17	7	90	1667	66	1425	4351	2023	232.20	22	68.45	CHANGED	LGEGPhWctp...........ppsLaWV......DIhstplaphsssssppp.....................hchss..........hlusls..h...ps..spllluhppul......................hlh..c.......hss........s....phphlsph..........sp.spsRhNDGpsDspGp.hahGoMshsttsst...........GsLYRlsss....tp.....lphhhss.lslsNGluaSsDspthYa.....sDohspp..lhta-hDhssu.lss++sa.hchppts......t....PDGhslDu.-GslWsAha.....suu......plh+asPp.Gc.llpplplP.sp.psTsssF.GGschssLalToAp	......................................................................................................................................................................................................................sEuPha...............p.tt.L......h..as................D.....l............t....t....p.....lh..p....h.....p.....t..s..t..t.....t.h.....................................................h.t..hst...................suh..hh.........tp.........sp.h...lh..s..........t.t.sh......................................................hhh.......s..............t.s..............................t.......ph..p...h.lhs..........................st.thsp..N...D.s.....h.s....c....s................p.G..p....ha.hs.s.....s.h...t...t.....t.tsh............................................utl.ap.lsss......tp..........................l.p.h.l..h...s.s......l..s.h...s.........N..G............ls.a..S..s....D....t..p.......hh..Yh.......................s-..o............h.....s.....pp...............lh.ta......s......h.....s.......p..s.......s..........l...s....s..t......c.hh....hp....hsttt..................................................PD..Gh.s....l......Ds...cG...s.l.a.s.A..h.h...........................su.s..........................tl....h..h..a....s.....P......p....G.......p.......h...l....tp..l.....t......lP....s.....t...t.....s.....s...shsF...u............G.....phppLalos..t.................................................................................................	0	451	825	1164
+8283	PF08451	A_deaminase_N		Adenosine/AMP deaminase N-terminal	Wuster A	anon	Pfam-B_3145 (release 18.0)	Family	This domain is found to the N-terminus of the Adenosine/AMP deaminase domain (Pfam:PF00962) in metazoan proteins such as the Cat eye syndrome critical region protein 1 and its homologues.	21.30	21.30	22.00	21.80	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.98	0.72	-3.96	32	240	2009-01-15 18:05:59	2005-08-26 09:39:06	6	5	76	4	102	235	0	85.10	33	19.39	CHANGED	hLhhshhhs.t.........................................psapppRstlhptEpthplGuclhLspcEppsNphlMp.lKp..cElpcuhhsstpFsPuhHFFcshshIcp.SslFpll	...............................................h.......................................................h.p.Rpthh.p.Ep.hthGs..pl.LsttEttsNphLMs.lKp..pElpcG...............hhss.p....FsPuhHFFcshshIcp.SslFphl.....	0	26	35	71
+8284	PF08452	DNAP_B_exo_N		DNA polymerase family B exonuclease domain, N-terminal	Wuster A	anon	Pfam-B_3196 (release 18.0)	Family	This domain is found in viral DNA polymerases to the N-terminus of DNA polymerase family B exonuclease domains (Pfam:PF03104).	21.00	21.00	21.00	34.50	20.40	17.20	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.58	0.72	-6.73	0.72	-4.67	6	88	2009-01-15 18:05:59	2005-08-26 09:45:14	5	2	48	0	0	82	0	22.10	77	2.21	CHANGED	M-I+ClNWFEs+G.Ep+FLYLKA	MDVRCINWFES+G.ENRFLYLKS	0	0	0	0
+8285	PF08453	Peptidase_M9_N		Peptidase family M9 N-terminal	Wuster A	anon	Pfam-B_4156 (release 18.0)	Family	This domain is found in microbial collagenase metalloproteases to the N-terminus of Pfam:PF01752.  	23.90	23.90	23.90	27.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.84	0.71	-4.96	34	561	2009-09-11 12:23:32	2005-08-26 09:47:51	5	11	300	3	58	499	2	179.60	32	22.09	CHANGED	hs.hspLsphs.pcLlstlps.hchsslssLFphsssstphhhscs+hpslhstLpppupsYsuss..u+ul.sLsEhLRAuaYltaYs..cplsthsst.hp.chhsulpAhhpNPsFh.ss..............cpQspllpuhshlls..NspppstslstshslLppaN...cshsp.hp.hs..........thsslaplhtGhpas.phht............hhtt	..........................hs.hu-LsphssppLs..chlss...hs.a...p...plssLFphspsshs.hh.scsphpslhstLsppupsYTt-s...u+slpshsEhLRuuaYlta.s..scls.hspt.hp.chhsulcshhpNsshhh.ss..............t-QspVl..suhupLIs..NA.us-s-slssshplLcpaN...cshsphspphs..........tssul.aslMpGhsashp.hh.....................................................................	0	19	31	45
+8286	PF08454	RIH_assoc		RyR and IP3R Homology associated	Wuster A	anon	Pfam-B_4135 (release 18.0)	Family	This eukaryotic domain is found in ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R) which together form a superfamily of homotetrameric ligand-gated intracellular Ca2+ channels [1].  There seems to be no known function for this domain [2]. Also see the IP3-binding domain Pfam:PF01365 and Pfam:PF02815.	22.10	22.10	24.00	22.30	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.60	0.72	-4.44	43	718	2009-01-15 18:05:59	2005-08-26 09:51:09	6	72	128	0	390	593	1	120.10	46	3.81	CHANGED	ppp...tppphcl..lppllRhLQLhCEGHNhshQNYlRpQsssc.....sohNllppslclLpsh...........................hh.ths....ppshclhhpsh-oLoEhlQGPCppNQ.sls..cophh-hsssll..........pphp	.......................s....ts.ph..hpslhRFLQLLC.EsHN...p..DhQ.NaLRsQss..p.......Ts.hNllhpTlpaL.plpt.....................................Sspss..ls.hGhh......p+sls.lhpQshpoLTEYhQGPCptNQ......pslA..cSphhDhlsuhl....p.................................................................	0	162	186	280
+8287	PF08455	SNF2_assoc		Bacterial SNF2 helicase associated	Wuster A	anon	Pfam-B_3199 (release 18.0)	Family	This domain is found in bacterial proteins of the SWF/SNF/SWI helicase family to the N-terminus of the SNF2 family N-terminal domain (Pfam:PF00176) and together with the Helicase conserved C-terminal domain (Pfam:PF00271). The function of the domain is not clear [1].	23.60	23.60	23.60	23.70	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.25	0.70	-5.89	42	1037	2009-01-15 18:05:59	2005-08-26 09:53:56	5	6	932	0	142	780	18	354.50	22	33.95	CHANGED	u+hlhlssshhcchlpll.ptpsh......th.h.shp.hthplhc.pchP.lp....Fslpcppp.ph.Lphppt.sh..lh.stphhhhpsslYhlspcppphltslh.phht...spppplpaspcppsphlppllPtLpplG..p.l.lstpl..cphhhpshpschahDphcp.plhsplpacY.G.shplsshpchp....................................phhlhRDhc+Epclhphhcph...............................sFttstpphh.h.ts-cplapFhpptlspLpphG.cVahocsh+slhhhpssp..stlclppp..shL-hsFchssIsppElpplLpulpcpccYY+LcsGphlsL-pcchpchpphlppLphptpchppt.lplst.cuhhlsshL...pshphlphscsFccllpclpp.-chpaplP	..........................................................................................................................................................................................................................+hlhhP.shhpphlphl.th.ph...........hp.pphp.hh.hp.hc...sphs..ht....Fplpch....p...p....h....plpl..pp......php...hh..pht..h.hh..h....ps....p..lY.....h.....lst.pp..hph..l....p.....t.lh....h.ht............tp.t.pp...pl.h...spschsc.hupsLshh...tphG...p..........sh....c..ph.t...h....p...s..h....p....spFah...Dp.............t.....c.....s..cl.phcl..pacY..G...sh.plsshpchp....................................ph.hspDhcpE...pclhp.lh.pt.h...............................uFp.t.s.............p....u...ah..h.....h..p.t-p.lYp.FhpchlPthc..plG.......c..V..hhoc.p...lcplh..hh.s.ssp.....tlplspp..sh..L-....l....p..F..Dhp.....s.....I.s.p.p.ElcpslpuLh.p.ppcaahhpsGpll.h.-....c..-.hp......clpphLpcL......thp.tphps.t.lplst.puh.lsphh.....cp....tsplphs...ppFppLspclppP-c..h............................................................	0	54	97	114
+8288	PF08456	Vmethyltransf_C		Viral methyltransferase C-terminal	Wuster A	anon	Pfam-B_2153 (release 18.0)	Family	This domain is found to the C-terminus of the viral methyltransferase domain (Pfam:PF01660) in single-stranded-RNA positive-strand viruses with no DNA stage in the Virgaviridae family.	25.00	25.00	64.60	64.30	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.50	0.70	-4.92	12	48	2009-01-15 18:05:59	2005-08-26 09:55:58	5	3	14	0	0	53	0	197.10	39	13.47	CHANGED	+VLptLRhph+-plshpslhpsshtKlFGpVShaQ+uL+saApWluas.aGsshlphcslPLYVEIpDRl+LWppts..spsFshshpDl--KlchacEhE+E+cclScplsp-K.....................h....s.csssscssschtthpc.tt+sshp-hhtG......c.......................alppWhpp.pspFshsppps........hhthh..hthlptlh-hhhPshphuslh.s--psptlp	.pVhphLRlphK-sVshtsLhpsAFhKVFGpVShaQ+AL+SFApWluYs.HGossIchpslPLYVEIsDRlKLWpptu.PspsFhLsh-DL-EKh+LaE.pE+E+pclSc+IlppK......hG...................pl...tst-htsschssch..hpcsRt+sshtchhEG......cVsTs...................hlppWsEp.-DHFshstpss......pshh.ah..h.hh+hl.-shhssh.Fuslh.ssDpstthc................	0	0	0	0
+8289	PF08457	Sfi1		Sfi1 spindle body protein	Mistry J, Wood V	anon	Pfam-B_54813 (release 17.0)	Family	This is a family of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins [1] which are present in microtubule-organising centres.	21.10	21.10	21.30	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	576	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.56	0.70	-13.25	0.70	-6.12	14	195	2009-01-15 18:05:59	2005-08-26 10:05:18	5	14	148	3	150	209	5	386.70	14	42.23	CHANGED	psh+shlptp.....sscTEcaap+LEcRAuRAR-laLlsKuFs+Wtphup-Elp+TssARRHlLp......h+hFpuWRplT.......sVNEhKup...+FhLp+saptW+p+scc..hcphcppAsphppcclh+psahpWahphst+c............Aspah-apl+++..............uL.aWhcKh+s....sc-clpthcshpc+hslspshphWpp+opsltstppcspshpcpplhpptLppW+hpApLtPhtpplssth-scllppuaspWtcchphhppAp-hcRt+lh+suaTsWpct.LRhpsLpsRh-..-..Rlhhcshh+WhLtpRhpLhQ+l+-pRlppssFssalsshpcphscL.cps-htcchcscclL+upLtpW+sphs.p+chEhtAsthatsRlhppslstW+s+hp+hsplpsa....AcsAchaFlsppslKpW+tAs.pot+cRRppuhtphRRphKhsL.AtcshspW+s+spchtsl-ppAhthtpp+shphshchlcpW+ppshcthpphcpA-.hatcplhpchLh+Wt-pltphpphpppAsth.c.cshtpssstL+KhShRhhp.l+uppcsAcsh+ERp.R+psRuhFctWhp+sc	....................................h........................................................................................................................................................................................................................................................................................................................................h..h.....................................h.......t......h..hhthh.......t.............h.........................hh....h.t........W..p...................h.....t.....t.thh.t.ht.Wt..........................t................p.........hh..........ht.......a......................p................................h...a.........ch.......h.thtp.p...h..h....pthh.....tt..ah....tt.................h....ph.t..tt.......h..t.t...hhpp....thhpthhthWp..p...tht........p...p...hp..........h......u..hh...t.......p...h......hh.thpt....t.h..t.p.ht.p.h...p.h...........ut.p.......hp.....hh...hhpthhp.....W...h..thcp..+ht...phh..t....hppt...h.p...h.pl...tphhph.........Whp....t....h....t.t....ht...hp.p....p.t..t..h..t........h..hhh.th....hthWttth...........t......t..........t........s.....h....t...p....h...h.t.h......hWh.t..h..th..........t.........h...............h.t.ht.h................................................................................................	0	59	93	133
+8290	PF08458	PH_2		Plant pleckstrin homology-like region	Fenech M	anon	Pfam-B_7298 (release 8.0)	Family	This family describes a pleckstrin homology (PH)-like region found in several plant proteins of unknown function.	21.80	21.80	21.90	22.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.36	0.72	-4.12	9	142	2012-10-04 00:02:25	2005-08-26 10:18:09	5	4	18	0	92	132	0	106.40	39	26.64	CHANGED	sELlpRsRpGsL+hKpVuVYINKpuQVhLKLKSKHlGGAFoKKpKslVhuVscplsAW..sG+chhpsu...........chhhFGL+Tu.pGllEFcCcSphcpphWspuVpsLLp.sustc	...................s-Lhp+T+cGsL+h+hVSVYI.N.......+p.u...pVhLKhKS+H.luGshoKKKKsVVhsVpp-lsAW...P..GRc...hh-su..........ccctY.FGL+Ts.pGl.lEF-.Ccs.p.tc.hchWspulppLLphss...p..........	0	11	50	71
+8291	PF08459	UvrC_HhH_N		UvrC Helix-hairpin-helix N-terminal	Wuster A	anon	Pfam-B_288 (release 18.0)	Family	This domain is found in the C subunits of the bacterial and archaeal UvrABC system which catalyses nucleotide excision repair in a multi-step process.  UvrC catalyses the first incision on the fourth or fifth phosphodiester bond 3' and on the eighth phosphodiester bond 5' from the damage that is to be excised [1]. The domain described here is found to the N-terminus of a helix hairpin helix (Pfam:PF00633) motif and also co-occurs with the Pfam:PF01541 catalytic domain which is found at the N-terminus of the same proteins.	21.30	21.30	22.80	24.40	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.85	0.71	-4.68	110	4453	2012-10-02 11:25:59	2005-08-31 14:14:15	6	20	4381	10	982	3406	2670	161.00	40	26.34	CHANGED	LpchLsLs.ph....PpRIEsaDlSHlpGsssVuuhVVFpsGtspKppYR+apIc....h.............stG......DDauuM+EVlpRRa..p+hhcpp........................................hPDLllIDGG+GQlssAhcllc.cLGl..s..ls.llGlAKspccpst...........lhhss......tcsltLspss.sLhllQ+lRDEuHRFAI	.....................................tphLtLs.t.h.....PhRIEsFDhSHh.t.G.ss.s.VuuhVVFps..u.tPpKs-YR+apI+....sl............................................sss.......DDYAuM+EVlpRRa..s+hlc.-.p...........................................................................................................................hPDLIlIDGG+GQlstAppVlp...EL.Gl......s......ls..lhGlAKssc+pss.........................lhhs..s.......t.tcsl....tLs.p.sS.sLaLlQ+lRDEuHRFAI............................	0	335	662	843
+8292	PF08460	SH3_5		Bacterial SH3 domain	Bateman A	anon	Pfam-B_1108 (Release 18.0)	Domain	\N	20.70	20.70	20.70	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.11	0.72	-4.06	15	1610	2012-10-02 18:48:24	2005-08-31 14:30:18	5	87	699	2	109	1038	6	64.90	33	24.53	CHANGED	.thspsGoahhssppsl...+ssPplouPsthhhppGsplhYDpV.hptDGasWluYsshsGsRtYlPl	.............s..hspsGsahhs..p..pssl...+spPpsu.u.s.l...h...s....ha.sGppl.p.Y.Dph.hptDGYp.......WloYh.u.hs.G...p...RRYls.................	1	25	50	77
+8293	PF08462	Carmo_coat_C		Carmovirus coat protein	Wuster A	anon	Pfam-B_4180 (release 18.0)	Family	This domain is found to the C-terminus of the Pfam:PF00729 domain in Carmoviruses.	20.80	20.80	20.80	21.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.40	0.72	-4.09	8	62	2009-01-15 18:05:59	2005-08-31 16:17:01	5	1	4	3	0	62	0	98.80	70	28.49	CHANGED	QASNDKVSDGPTYVVPSVNGNELQLRVVAAGKWCIIVRGTVEGGFTKPTLIGPGISGDVDYESARPIAICELVTQMEGQILKITKTSAEQPLQWVVYRM	........QASNDKVSDGPTYVVPSVNGNELQLRVVAAGKWCIIVRGTVEGGFTKPTLlGPGISGsVDYESA.RPIAlCELVT.QMEGQILpITKTSAEQPLQWVVYRM.	0	0	0	0
+8294	PF08463	EcoEI_R_C		EcoEI R protein C-terminal	Wuster A	anon	Pfam-B_4136 (release 18.0)	Family	The restriction enzyme EcoEI recognises 5'-GAGN(7)ATGC-3' and is composed of the three proteins R, M, and S. The domain described here is found at the C-terminus of the R protein (HsdR) which is required for both nuclease and ATPase activity [1,2].	22.80	22.80	22.80	23.20	22.30	22.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.01	0.71	-4.39	125	1424	2009-01-15 18:05:59	2005-08-31 16:20:10	5	18	1139	0	251	1037	195	157.50	23	17.71	CHANGED	pchpca.tthpp..hlppp.hsshssLpplhss....pphppp.LccLppthh..pt.....h..hstp...pl.p.....................t..sslhsll+plh..uh.-....hhshc-+spp.th..ppah......tpts.....hss.pQtcaLch.............................lhcpht..ppGhh-.....cshphss..Fpp..Gs.tplt..hFt........plpphlpclpctlh	............................................phpcY...scc..hltpp..hss.sshpplaps.....tchppt.lccLpphhh..ct......ltppt..shpp................................thchhchlpcl..uh..s.........hshpER...spp.th....spah...................................sphs.....hsppthphLch.............................llcphh-p.Glh-....hcsLphtP...F.pph..Gs..tl...phFsst.p........ph.pslpclpptl........................	0	75	171	214
+8295	PF08464	Gemini_AC4_5_2		Geminivirus AC4/5 conserved region	Wuster A	anon	Pfam-B_4177 (release 18.0)	Family	This domain is found in replication initiator (Rep) associated proteins such as AC5 in the Geminivirus/Begomovirus.	25.00	25.00	56.30	55.40	22.80	21.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-7.90	0.72	-4.23	17	174	2009-01-15 18:05:59	2005-08-31 16:21:10	5	2	91	0	0	174	0	43.00	59	26.82	CHANGED	MpsIlshhKRLcLThAFTu.tpIhuSlHsVasGLsVHtPVsPs	..MtsIlsthKRLcLThAFTustcIhsSlHsVHsGhuVHGPVsPs.	0	0	0	0
+8296	PF08465	Herpes_TK_C		Thymidine kinase from Herpesvirus C-terminal	Wuster A	anon	Pfam-B_4030 (release 18.0)	Family	This domain is found towards the C terminus in Herpesvirus Thymidine kinases.	20.10	20.10	20.50	32.80	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.38	0.72	-4.44	12	34	2009-09-11 05:18:18	2005-08-31 16:21:50	5	2	26	0	0	33	0	32.70	48	5.80	CHANGED	pFpcDlsGlWspIYsQlh+NsuIKs+hlsWsAL	.pFpDDlsGhWocIYpQlhpNsAIKophlcWsuL..	0	0	0	0
+8297	PF08466	IRK_N		Inward rectifier potassium channel N-terminal	Wuster A	anon	Pfam-B_4080 (release 18.0)	Family	This metazoan domain is found to the N-terminus of the Pfam:PF01007 domain in Inward rectifier potassium channels (KIR2 or IRK2).	25.00	25.00	28.60	27.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.06	0.72	-4.05	5	111	2009-01-15 18:05:59	2005-08-31 16:22:24	5	2	41	8	60	91	0	45.20	67	10.61	CHANGED	MuuuRTNRYSIVSSEE-GL+LuTMuusNGFGNG..KVHTRR+CRSRF	......MuusRsNRYSIVS.S.EEDGh+LsTMu.....sA.NGFG.NG...KV....H.T.RppCRsRF..	0	3	11	28
+8298	PF08467	Luteo_P1-P2		Luteovirus RNA polymerase P1-P2/replicase	Wuster A	anon	Pfam-B_4011 (release 18.0)	Family	This domain is found in RNA-dependent RNA polymerase P1-P2 fusion/replicase proteins in plant Luteoviruses.	20.50	20.50	86.80	86.70	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.21	0.70	-5.65	4	151	2009-01-15 18:05:59	2005-08-31 16:23:28	5	2	10	0	0	154	0	332.90	77	58.24	CHANGED	h.F-.LIsASA+sVKDFISaCYsRh+SlYYuhKRWLhElpGpFcAHDAFVsMCastMhsIE-FEtELAEEauptEsEVp.AcshhKhLVAptu...........sGspcuhsDF..ltuRuGsasPl..............uCcs+Spp..s+s-Kh.pLlccpclh...Es+ht+sY.cEhGcu.hspW.NsL.oRhphlKcstccttcNAKtAp+lss.hptsssIsDhhuhsEVspV-TG.ph.spKshpGEEhspspPhlc.VRRlK..sEstssApsaIpppI+.pN.pL.sus-lShATIsRYs.phsEchcLDlsSpThLhphAMh.VPlPpppDIctthllQSPsARplR-chsVLsSpsF	.hFFElLIGASuKAVKDFISHCYSRLKSIYYSFKRWLMEISGQFKAHDAFVNMCFGHMADIEDFEAELAEEFAEREDEVEEARSLLKLLVAQKS............KoGVTE.AWTDF.FhKSRGGVYAPL.....................SCEPT+QELEsKSEKLE+LLEEQHQF...EVRAAKKYIKEKGRGFINCW.NDLRSRLRLVK-VKDEAKDNA+AAAKIGAEMFAPlslQDLYSFTEVKKVETGLhKEVlKEhNGEEEK+LEPIhE-VRSIKDTAEuRDAASTWITETVKLKNSTL.sADELSLATIARYVENVGDKFKLDIASKTYLKQsAoMSVPIPTsKDIKhKMVLQSPEARA+RERMDVLDSsGF	1	0	0	0
+8299	PF08468	MTS_N		Methyltransferase small domain N-terminal	Wuster A	anon	Pfam-B_4172 (release 18.0)	Family	This domain is found to the N-terminus of the methyltransferase small domain (Pfam:PF05175) in bacterial proteins [1].	21.10	21.10	21.20	21.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.76	0.71	-4.38	19	926	2009-01-15 18:05:59	2005-08-31 16:25:02	6	2	917	1	125	547	57	151.90	52	45.12	CHANGED	SpVlhRphchFps+pVLlAGplpDphPtpLsthspplpsao..aaas.ththptpsslphp..hsspts..t.sDhllhYWPKuKpEAca.LttLlupLshGpEIhlVGENRuGV+Ss-KhLssa.GplsKlDSARRCuLaas.plpppPp.FsLcsaa+pY	...................................................SEVLLRHuDpFppp+lLFAGDlpDDLPAcLc.ss..u..u..+.uc.s.p..........aHHap.sl.up.p.......h...s.-..ss+Fu........Ls.A.p...s..ss...s......u..ssDTLIYYWPKsKsEApFQLhsLLShLPsGs-IFVVGENRSGVRSAEpM.L.A.-Y.u.s.l.sKl.DSARRCGLYaG.+LE+p..Pt..F-h-paWtpY....................	0	20	45	88
+8300	PF08469	NPHI_C		Nucleoside triphosphatase I C-terminal	Wuster A	anon	Pfam-B_4183 (release 18.0)	Family	This viral domain is found to the C-terminus of Poxvirus nucleoside triphosphatase phosphohydrolase I (NPH I, [1]) together with the helicase conserved C-terminal domain (Pfam:PF00271).	21.00	21.00	21.60	21.00	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.83	0.71	-4.31	13	67	2009-01-15 18:05:59	2005-08-31 16:26:02	5	4	49	0	1	57	7	146.10	57	24.20	CHANGED	HhssP.ERRYVNVHFIIA+hosGcsoVD--LL-II+sKS+EFsQLF+VLKpoSIEWIasppKsFpPVDDEoGacsLhSRsl..D-sstosphh+ltpGpNIWYSpSschloIhKGFKscD.G+IYDs-Gsalpshs-N...Pll+IcssKLlYI	...................HVhTPPERRYVNVHFIhARLSNGhsTVDEDLh-IIpoKSK.EFsQLFRVhK+oSlEWI+sspK.DFSPlDsESGWcsLlSRuI..DhssKpshssKLl-GpNIWYSsSsRLhoIp+GFKssD.GRlYDsDGNaLpsMPDN...PlIKIHsGKLlYI.........................................................................	0	1	1	1
+8301	PF08470	NTNH_C		Nontoxic nonhaemagglutinin C-terminal	Wuster A	anon	Pfam-B_4024 (release 18.0)	Family	Bacteria of the Clostridium genus produce protein neurotoxins, which are complexes consisting of neurotoxin (NT), haemagglutinin (HA), nontoxic nonhaemagglutinin (NTNH), and RNA [1, 2].  The domain described here is found at the C-terminus of the NTNH component.	23.90	23.90	24.20	26.30	21.70	23.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.23	0.71	-4.61	7	75	2009-09-10 15:40:16	2005-08-31 16:27:13	5	3	29	2	3	60	1	162.30	68	14.08	CHANGED	NYFssLNNSYIRDuscERLEYNKsYpLYNYVFP-sslhEVppNNNIYLSIpNpsNLNlpssKFKLlslssNKQYVQKWDEVIIsVLsspEKYlDISsENNRIQLVssKssA++hIlNNDIFhsNCLThuaNNKYlsLSh+spNYNWMICNssppIPKtAaLWILK	................NYFpsLNNSYIRDSscERLEYNKTYQLYNYVFs-pslhEVppNNNIYLoINNTNNLNlQuuKFKLlsIssNKQYVQK.....aDEs.IIslLDshEKYlDI.S.EsNRlQLlssKssAKKhIIsNDIFISNCLThoYNsKYlsLShKDcNYNWMICNNspplPKtuYLWhLK.................	0	1	3	3
+8302	PF08471	Ribonuc_red_2_N		Class II vitamin B12-dependent ribonucleotide reductase	Wuster A	anon	Pfam-B_4121 (release 18.0)	Family	This domain is found to the N-terminus of the ribonucleotide reductase barrel domain (Pfam:PF02867).  It occurs in bacterial class II ribonucleotide reductase proteins which depend upon coenzyme B12 (deoxyadenosylcobalamine) [1].	21.60	21.60	22.00	32.80	20.30	19.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.16	0.72	-3.90	47	480	2009-01-15 18:05:59	2005-08-31 16:31:44	5	13	471	0	161	391	512	99.30	52	8.97	CHANGED	DGolVFc.cslEVPppWSQlAsDllAQKYFR..KsGlPt+..................t.t..........hssEsSh+QVhcRlsGsWshWG.hKsGYFso-sDAcsFaDEhtahLhpQ	....DGolVFc.cslEhPstWSpsAusIlApKYFR...psGsPs+...............................................EsSh+QlhDRlssTashhG.hK.sGYFs.S....--DApsFt-ELsahLspQ.......	0	64	112	136
+8303	PF08472	S6PP_C		Sucrose-6-phosphate phosphohydrolase C-terminal	Wuster A	anon	Pfam-B_4159 (release 18.0)	Family	This is the Sucrose-6-phosphate phosphohydrolase (S6PP or SPP) C-terminal domain [1] as found in in plant sucrose phosphatases. These enzymes irreversibly catalyse the last step in sucrose synthesis following the formation of Sucrose-6-Phosphate via sucrose-phosphate synthase (SPS).	20.20	20.20	21.40	21.80	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.88	0.71	-4.54	15	99	2009-01-15 18:05:59	2005-08-31 16:33:44	5	8	33	0	46	100	2	119.50	41	30.38	CHANGED	GPNlSPRDl.DF.s..csKhE......shsPuc-VVKFYLFYEKWRRAEVEpS-ha.....lsslKulscPuGVhlHPSGlEpSL+ssIsu.L+sCYGDKQGKpFRlWVDpllsTplGSsoWLVKFDKWEhsG-ERpCClTTllLosK	...............................GPNlSPRD......l....-h.s........c.c...........shpPuctVV+FYlhaE+WRRuEV.po-th.....hphhKslscssGshlHPuGhEpsL+ssI-s.LtspYGDKpGKpaRhWVDplhssp..huossWL...V+FcpWEh.p.Gpth.sChoohhls.K...............	0	9	32	39
+8304	PF08473	VGCC_alpha2		Neuronal voltage-dependent calcium channel alpha 2acd	Wuster A	anon	Pfam-B_4072 (release 18.0)	Family	This eukaryotic domain has been found in the neuronal voltage-dependent calcium channel (VGCC) alpha 2a, 2c, and 2d subunits.\	 It is also found in other calcium channel alpha-2 delta subunits to the N-terminus of a Cache domain (Pfam:PF02743).	20.80	20.80	20.80	21.00	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.24	0.72	-4.21	2	161	2009-01-15 18:05:59	2005-08-31 16:34:57	6	7	49	0	67	128	0	91.60	59	9.28	CHANGED	LDAEhEs-lKV-IRppMIDGEpuphpF+TLhKSQDERYIDKG.RTYTWoPVsssDYSLALVLPsYSh.YIKAplt-TITQA+........SEoL	......LDAELEs-.K.EIR+pMIDGcsG-+p.h+TLVKSp...DE.....RYIDcssRTYTWsPVpGTDY....S....L..uLVLPs.YShaYIpAp...lp-sIhQs+.h......................................	0	5	12	32
+8305	PF08474	MYT1		Myelin transcription factor 1	Wuster A	anon	Pfam-B_4029 (release 18.0)	Family	This domain is found in the myelin transcription factor 1 (MYT1) of chordates.  MYT1 contains C2HC zinc finger domains (Pfam:PF01530) and is expressed in developing neurons of the central nervous system [1] where it is involved in the selection of neuronal precursor cells [2].	20.60	20.60	20.70	22.00	17.70	20.30	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.82	0.70	-4.89	3	273	2009-01-15 18:05:59	2005-08-31 17:44:20	6	25	37	0	104	204	0	181.60	45	24.52	CHANGED	YRsNVAsTTPRANLAKELEKFSKVoFDYASFDAQVFGKRhlAPKlQTu-sSPKuaQcAKPFsKssSPcSSsoSSYV+SSSSssSu..GupspSTsptSSFDYoQDuEAAHM.AATAILNLSTRCREMP-NLSTKPQDL.soKusDIEVDENGTLDLSM+KpRhRDpuhPsoSSCooIsTPpSP.SPQ+p......SSulsNspsaQ.Lu-QDsWDlPlDYT..KP+RlcEEEsKEp-Psshs.upEsLEE++auGEsoIPSPKPKacpRK	.....................a+ss.sssoPRusLuKE.EKauKssF-Y.sSaD....s....p....s...aGKR...hPh.l.p.s...pph.....p.....................................................................................................s.asYsps.EssHh.AAsAILNLSTRChE..h.sp.LSsKPQs.L....s+ss-...hEVDENGTLDLSMpKp+.t-.........ssss....ss.p..ss.pp..............hhsst..Q.hsc.t-tW-..hPlsYo..KspthpE.-.-...c...............-.....................p.......s.....................s...........................................................pt........h--pchstE..............................................	1	4	12	39
+8306	PF08461	HTH_12		Ribonuclease R winged-helix domain	Bateman A	anon	N-terminus of DUF128 family	Domain	This domain is found at the amino terminus of Ribonuclease R and a number of presumed transcriptional regulatory proteins from archaebacteria.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.09	0.72	-4.24	10	1050	2012-10-04 14:01:12	2005-08-31 18:07:20	5	14	1020	0	197	812	52	64.30	54	8.60	CHANGED	lEILsILuEuccPlGAKhIApELcpR.GYcIGERAVRYHL+hLDEcG...LT++lGYu....GR.ITEKGl-EL	.................E.FIL-aL...sc...+c...p...PA.SR-ELAsELplcsEEQl..EuLRRRLRA.MERDGQLVF..T.R....R.Q..C.Y.A................LPE+.LD..........................	1	42	102	154
+8307	PF08475	Baculo_VP91_N		Viral capsid protein 91 N-terminal	Wuster A	anon	Pfam-B_4034 (release 18.0)	Family	This domain is found in Baculoviridae including the nucleopolyhedrovirus at the N-terminus of the viral capsid protein 91 (VP91) [1].	21.80	21.80	159.30	152.90	19.40	17.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.18	0.71	-4.92	27	63	2009-01-15 18:05:59	2005-09-01 10:08:50	5	2	56	0	0	65	0	186.40	39	23.89	CHANGED	LLLlsIlllllFhlhahhIhs-FsEssFssRLpVlpEYh+pss..u-pPlPssLuYVScV..ssshYhVThFsTpsLpphppplHDDphEhFsFlpQpFp......................ss.sspsRVpspssDsscFhl+uDDG..lphcC..PpstpFDss..cCVPlssC.scssGp.hPlTEchlDpLVhN++ss+p....t.sspphHPT	.LLLlAIlllllFslhYlhIhs-FsEssFssRLpVlsEYh+RTN..A-pPhPcsLuYVS-V..spphYhVThFsTssLsslppolHDDphEpFsFlpQpFp......................ssssspsRVpsp.ssDsscFhl+GDDG..hphcC..PsstpFDtst.+CVPlPsCts+ssGp.YPlTEchlDsLVhN++ls+s.....t..ssspthHPT.....	0	0	0	0
+8308	PF08476	VD10_N		Viral D10 N-terminal	Wuster A	anon	Pfam-B_4155 (release 18.0)	Family	This domain is found on the N-terminus of the viral protein D10 (VD10) and the related MutT motif proteins [2].  The VD10 protein is probably essential for virus replication [1] and is often found to the N-terminus of a Pfam:PF00293 domain.	25.00	25.00	52.70	52.70	21.00	17.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.14	0.72	-4.49	7	51	2009-01-15 18:05:59	2005-09-01 10:13:46	5	2	38	0	0	39	0	44.80	58	18.60	CHANGED	hpha.Sslhs.IhppNR+LoKTalhpDssQ+lpsTuFspQpLchh	.MsaY+SSllSpIIKaNRRLuKohIhcDDSQhITLTAFVNQsLasH..	0	0	0	0
+8309	PF08477	Miro		Miro-like protein	Fenech M	anon	Pfam-B_1154 (release 17.0)	Family	Mitochondrial Rho proteins (Miro-1, Swiss:Q8IXI2, and Miro-2, Swiss:Q8IXI1), are atypical Rho GTPases. They have a unique domain organisation, with tandem GTP-binding domains and two EF hand domains (Pfam:PF00036), that may bind calcium. They are also larger than classical small GTPases. It has been proposed that they are involved in mitochondrial homeostasis and apoptosis [1][2].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.36	0.71	-10.61	0.71	-3.61	17	1563	2012-10-05 12:31:09	2005-09-01 11:57:45	8	235	397	7	1022	40314	7022	116.40	20	16.79	CHANGED	+lsllGctssGKoSllpphhttphs.............h-hpssshshp.....hhs.ssst...........h...-.stt.......hthp......hppusuhlllashsctpohpplp.hh.hlsphcp.t.t.lPllllusKhD	.....................................................................+lhllG.s...t..u..sG...K.......o......o..L......l.p..p....h..h..s..t..s.hs....................................................................p..t..h...t...p..s...p...h...s....h.p................h.....h..p..s.p..pph...............................................l...l.h.....-....h....u....s.p...................................t.t.h...t...h.....t.................................hp.......t....s.....c.....s......l....l.....l......l.........a....s......h.........s........c........t................p........o.....h....p..........t.....l..............p.............h.........h..................h...........l.........................p.............h.........p...........t..............................................p.....l......P.....h..l..l.l.u.s+.D......................................................................................................	0	351	546	791
+8310	PF08478	POTRA_1		POTRA domain, FtsQ-type	Fenech M	anon	Pfam-B_1605 (release 7.0)	Family	FtsQ/DivIB bacterial division proteins (Pfam:PF03799) contain an N-terminal POTRA domain (for polypeptide-transport-associated domain). This is found in different types of proteins, usually associated with a transmembrane beta-barrel. FtsQ/DivIB may have chaperone-like roles, which has also been postulated for the POTRA domain in other contexts [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.83	0.72	-3.93	92	3670	2012-10-01 23:48:22	2005-09-01 14:28:48	5	6	3629	6	775	2508	1251	69.80	23	23.53	CHANGED	hslcplplsG.sphlsppclhphhslph..tsshh..tlshsplppplpp.hPalcpspVp+p.aPs.plplplpE+	........................lpplplp...G..s.....ph..sssp..clpps.h.thts.......ssshh...........ph...c...hsth.p..pplcp..hPa....lcpsp.Vc+p..aPs....plplclpEh...............	0	252	491	639
+8311	PF08479	POTRA_2		POTRA domain, ShlB-type	Fenech M	anon	DOMO:DM07489;	Family	The POTRA domain (for polypeptide-transport-associated domain) is found towards the N-terminus of ShlB family proteins (Pfam:PF03865). ShlB is important in the secretion and activation of the haemolysin ShlA. It has been postulated that the POTRA domain has a chaperone-like function over ShlA; it may fold back into the C-terminal beta-barrel channel [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.15	0.72	-4.31	60	1933	2012-10-01 23:48:22	2005-09-01 14:29:39	6	19	922	6	495	1965	284	75.00	24	13.68	CHANGED	aslpplp.lpG....sp.....hls.t.plpplhpshhu+slshsslspLspploshYlp+GYlToRshl.ssQ..sl.ssGt.LplpVlEG	................................................lpplp..lpG........sp...........hstt...tl...p....phh..p....s...h...h..Gc.slshpslp....t....lh...ptlsphhh.s+GYlT...ocshl...P...tQ.....sl..ps.G.h..lplpll.G........................	2	80	250	391
+8312	PF08480	Disaggr_assoc		Disaggregatase related	Wuster A	anon	Pfam-B_4000 (release 18.0)	Family	This domain is found in disaggregatases and several hypothetical proteins of the archaeal genus Methanosarcina. Disaggregatases cause aggregates to separate into single cells [1] and contain parallel beta-helix repeats.  Also see Pfam:PF06848.	20.90	20.90	21.30	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.59	0.71	-4.87	21	34	2012-10-02 14:50:22	2005-09-02 16:30:26	5	12	6	0	31	42	2	190.60	46	24.16	CHANGED	MsDIEIYNNsIasThusGIWlhGYs.uuYoKspAtsVaIHHNhFYsTGTNsuhsWlGGIVssGF.sTLIENNVFDGsYsAAIs.phhspt.....phuPsG..sGYsThVRNNIIsNTh......spusuGoGYGlhNhL.spTHoFlLpNNClYNNuuGsYtsss.SsoDIhsDPhas-pppHDYHLKS.sG+WsGpsWVpDtlsSPCIDAG	........................MsDIEIYNNhIasTaGPGIWlhGht...suYsKsputsVaIHHNhFYsTGTNss...l.....pWlGGIl..sS.GFhs...oLIENNVFDGsYpAAls.phYsst..............thuPsG..oGYT.ThVRNNIIsNTh.R....ppsssGoGYGlh....NhL.scoHsFlLcNNClYNNuuGsYpNss.SsoDI.sDPhFssppp+DYHL+SpsGpWssptWhpc.h.SPCIDsG................................	0	10	10	10
+8313	PF08481	GBS_Bsp-like		GBS Bsp-like repeat	Wuster A	anon	Pfam-B_2122 (release 18.0)	Family	This domain is found as a repeat in a number of Streptococcus proteins including some hypothetical proteins and Bsp.  Bsp is a protein of group B Streptococcus (GBS) which might control cell morphology [1].	20.00	20.00	20.20	20.10	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.53	0.72	-4.11	50	1326	2009-01-15 18:05:59	2005-09-02 16:33:46	5	104	156	0	188	1240	1	91.80	34	44.51	CHANGED	lslpststpsGsaclhlssl.sssslpsVtlPlWS-pNsQDDlpWYsAs+pssGoapsslchssHpsp.GpYplHlY...shssGphhGlsuTs.hpV	..............................lp.pstpsusa-lhlosl...s..s..p.s.lppVplPsWScpNGQDDlh..WYsAs.+....ps...cGo.YpsslphssHcsptG...pYplH..lY..hhpssGphhG.lsuTshp................................	1	19	53	118
+8314	PF08482	HrpB_C		ATP-dependent helicase C-terminal	Wuster A	anon	Pfam-B_2170 (release 18.0)	Family	This domain is found near the C-terminus of bacterial ATP-dependent helicases such as HrpB.	25.00	25.00	34.60	33.70	23.40	22.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.65	0.71	-4.02	136	1495	2009-01-15 18:05:59	2005-09-02 16:40:32	5	8	1469	0	345	1253	181	132.00	52	16.94	CHANGED	WLtPaLsGlpshsplpplclhsuLpuhL.sWs..ppppL-phsPs+hssPoGs+lsI-Y..............ssst..PsLuVRLQEhFGhspsPplu........sG+lPlhlcLLSPAtRPlQlTpDLsuFWpuoY.t-V+KEMRGRYPKHsWP-DP	..............................WLhPah...s...GlpsLp.sL.psl-lhpALcuLL....sWs...hpQ..+LDp.hPsHasVPoGS+.lsIcY.......................................p.p.-s.....sPsLAVRhQEhFG.s.ssPslA........pG.RVPLlLcLLSPApRPLQlTcDLuuFWpG.uY.t-VpKEM+GRYPKHsWPDDP.............	0	98	201	282
+8315	PF08483	IstB_IS21_ATP	IstB_N;	IstB-like ATP binding N-terminal	Wuster A	anon	Pfam-B_3188 (release 18.0)	Family	This bacterial domain is found to the N-terminus of the Pfam:PF01695 like ATP binding domain in proteins which are putative transposase subunits [1].	20.80	20.80	20.80	20.90	19.60	20.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.00	0.72	-7.05	0.72	-4.27	15	366	2009-01-15 18:05:59	2005-09-02 16:44:39	6	4	226	0	141	347	108	30.00	42	12.31	CHANGED	cEQtspsss.ssLSF-ERLGLLlDRElspR-	.......cQhspPsh.ppLuFEERLuLLl-cEhspR-.....	0	49	87	116
+8316	PF08484	Methyltransf_14		C-methyltransferase C-terminal domain	Wuster A	anon	Pfam-B_2106 (release 18.0)	Family	This domain is found in bacterial C-methyltransferase proteins. This domain is found C-terminal to methyltransferase domains such as Pfam:PF08241 or Pfam:PF08242. But this domain is not a methyltransferase.	20.20	20.20	20.20	20.40	20.10	19.80	hmmbuild  --amino -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.92	0.71	-4.68	24	606	2009-01-15 18:05:59	2005-09-02 16:47:16	6	15	457	10	185	611	1437	149.00	30	37.09	CHANGED	lssHGGSlRlhhs+pssppsss....pVscllspEpstGLsphssYppFucRlcph+cpLlsaLtpt+spG+plhGYGAssKGNTlLsaCGlspc.lsalsDpsshKpGpho.PGo+IPIhss-chtshcPDalLlLsWNap-EIlpcppthhstGG+hlhPlP	............................................shaGGSlphhht...t.s.t.......t.......tltthhttE............thslpp..t.ha.tt.Fspcspp.h+ppll.......phLh.p.h+s.pG.+.plsuYGAsuKGs....TL...LNa.s...Gl.ss...-.h.lsallDp.N.PtKpG.+ah..PGo+.IPIhsPc.p..l.pp..p..p.P..D...h..l.ll.L.s.WNhp...-EIhpphp..h.h.p..Guphlh.lP...............................	0	62	135	158
+8317	PF08485	Polysacc_syn_2C		Polysaccharide biosynthesis protein C-terminal	Wuster A	anon	Pfam-B_4073 (release 18.0)	Family	This domain is found to the C-terminus of the Pfam:PF02719 domain in bacterial polysaccharide biosynthesis enzymes including the capsule protein CapD [1] and several putative epimerases/dehydratases.	25.00	25.00	27.40	26.90	23.10	21.70	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.37	0.72	-4.46	50	564	2009-01-15 18:05:59	2005-09-02 16:49:37	5	3	510	0	93	379	199	47.90	54	14.07	CHANGED	DsRDLNYsKYFpEG-pcloph...-DYsSHNTcRLsV-thKcLLLcL-aIp	..DsRDLNYsKYhcpGsc+loph...p-YNSc.NTchLsVEplK-hLLpL-al+....	0	30	61	79
+8318	PF08486	SpoIID		Stage II sporulation protein	Wuster A	anon	Pfam-B_1108 (release 18.0)	Family	This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation [2].  The domain is also found in amidase enhancer proteins.  Amidases, like SpoIID, are cell wall hydrolases [1].	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.40	0.72	-3.72	160	1665	2009-09-10 14:51:08	2005-09-02 16:51:50	5	45	1176	0	415	1429	537	101.00	27	22.16	CHANGED	lhst.ts..php.....hlsp.lslEcYLtGVVuuEMsusas.hE...ALKAQAVAARTYAltphtp........................................ttps...hclss.ospsQVYtu............hpstp...spsp......pAVpsTpGpV.LsY	...........................h....ttphphls.p.lsh.E.-YltuVlssEhs..s..oa..s....hE.............ALKAQAVAuRTa....slp.phtp...................................................ptp.s...h.s.lss...ostsQs.Yts................................hpt....p..hp.........pAlptTtG.llh........................................................	0	188	317	379
+8319	PF08487	VIT		Vault protein inter-alpha-trypsin domain	Wuster A	anon	Pfam-B_2015 (release 18.0)	Family	Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition [1].  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.	21.30	21.30	21.40	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.27	0.71	-4.41	18	1019	2012-10-10 13:59:34	2005-09-02 16:53:43	5	50	337	0	559	925	68	115.20	29	13.23	CHANGED	sslslhShpVcSploSRaA....+TsVoScslNpuspspEstFplplP+pAFIoNFohhIsGpsasGpIK-KptApp.Ypc.ApucG+oAuLV+ssupshEpFpsSV.sVsssoKVsFcLsY.pE	..............................h.lhshplps.pl..suphA....psslspphh....N.ps......s.p.s...h..Es.ha.h.LPc.sAhlssFph...........p..l.s.s.c.s..h..hGplKE.Kp....pA..+p.pYcp.....Ah.s.pG..c...sAuL..l......c.......p.s.s.t.s..h..............F.pssV..Nlsss.sc.lphpLpYt.........................................	0	184	259	391
+8320	PF08488	WAK		Wall-associated kinase	Wuster A	anon	Pfam-B_4138 (release 18.0)	Family	This domain is found together with the eukaryotic protein kinase domain Pfam:PF00069 in plant wall-associated kinases (WAKs) and related proteins.\	\	    WAKs are serine-threonine kinases which might be involved in signalling to the cytoplasm and are required for cell expansion [1].	21.30	21.30	21.60	22.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.65	0.72	-3.71	14	91	2009-01-15 18:05:59	2005-09-02 16:56:30	6	13	11	0	77	112	0	106.30	25	17.43	CHANGED	sp.hCsGhtCCQAp.lPspp.QlIGVsIEsssstspst.tGC+V.AFLTscpYu.SNsT-PEphaupGYssVELGWahpTosppFhss..LuCpNhs-......Yssss...........pChCcY	...................................................t.CsGhsCCQsp.lP.st..h......Q.l......hs.....sslps...p.s..t.s.psp..ssCch.AFLs-c...p.......a...h.h.s...s....hosP.p.ph..p....st.....tYss.l.LsWhh..p...s.......s...s......p....h..........ss......hsCps.p..............hsttp.............pC.Cp.......................................	0	16	52	60
+8321	PF08489	DUF1743		Domain of unknown function (DUF1743)	Wuster A	anon	Pfam-B_4001 (release 18.0)	Family	This domain of unknown function is found in many hypothetical proteins and predicted DNA-binding proteins such as transcription-associated proteins.  It is found in bacteria and archaea.	20.80	20.80	21.10	24.00	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.42	0.71	-4.34	59	216	2009-01-15 18:05:59	2005-09-02 17:02:30	6	3	149	7	150	227	81	117.20	29	29.78	CHANGED	sRGllGAhAulut.................caTaEllsYRhsp.hsp.pRplshpslht.hctcphPhsacslD.htcchllsP+sssPVLaGI...RG.s.tslhpstphl.ps.E.....phpthtIahTNQuTDsH	...s+GllGAhuulut.h..........tcaTaEhlsYRtscphsp.pRplstsolht.hcppshstsacslDhhpcchllsP+ossPVLaGI...RGhs.tslhpstphl.pstE.........hpthtlahTNQsTD.H..............	0	35	93	125
+8322	PF08490	DUF1744		Domain of unknown function (DUF1744)	Mistry J	anon	Pfam-B_5917 (release 18.0)	Domain	This domain is found on the epsilon catalytic subunit of DNA polymerase.  It is found C terminal to Pfam:PF03104 and Pfam:PF00136.	20.40	20.40	21.50	21.10	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.14	0.70	-5.89	17	355	2012-10-02 01:06:00	2005-09-05 12:53:33	7	10	276	0	260	359	14	351.10	32	18.13	CHANGED	slpplYpchhpphhp..t.tphtphh.hs-shsFplphhostcphh+plschlpph+cp+ss.sllhlQSsh.hppltppl.hLspFPhlpl..s.s-sslssLsWQphhu++hlpHaLslusWlsphlphu+YuclPlsNlphDshtFhlDlhaAR+LpppNhVLWWSss.shPDhGGhEpD...phsh.h-clt....PslNsPGhYsslslElplpsLslNolLpSullNEhEGus.s..s.sh..ps..........s.sstssasEsuhsssuhpVL+phlKcWac-.uhpsNshAD.l......lpphhpWVpSssShLaDsuL+halcsLh+KshLQLluEF+RlGuplIaAshN+lllpTsKhslpsuhAYupYll+ul+o+slFpalcLplt+YWDhLlWMDpaNaGGh	...............................................................................................................thatt.h.hh.t.........t..t..h....pphpFc.sp..sshcphhctl..........pchltth+p..p...c.....p...t..s.s....llslQS..s.....................h.........p........pL..h.pt..ls.h.Lp-aPhl..l......................s.....sc..ths...s.............L..sWQphsu+phlp+ahsh.sph.lpp.hhphu.R.......YhclP...lsNl.........t.............D..shahhDlh..aARpLpppshlLWhS..ss.shPDhGGh...EtD.......phhh..h.-pht......................splNpsGsYso..VClELclp.s.LAl.Nsl.L..pSshls-.h..E....G.u..ssh....hs.ss...tt...............................ttss.ss.sta...s-.s.uhssssh.pl.L+pMVp.sWhp-....s......tt...t...N...h...hA....D..........l.+.......hhR.WlpSs..sShL.aDsuL+phlpth......h+KhFhpLluEF.+.RlGupllaAs..hs+lllpTsKtplt.sA........hA.......YspYllpol+s.....+...........lFchlslphpchWchL.lWhDthNaGGh............................................................................	0	97	148	220
+8323	PF08491	SE		Squalene epoxidase	Wuster A	anon	Pfam-B_3107 (release 18.0)	Family	This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria.\	      SE was first cloned from Saccharomyces cerevisiae where it was named ERG1.  It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway [1].  Putative transmembrane regions are found to the protein's C-terminus.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.82	0.70	-5.57	13	429	2012-10-10 17:06:42	2005-09-06 09:10:11	5	17	277	0	255	1836	818	239.90	39	51.57	CHANGED	aAsLTlVCDGhFS+FR+sLs.sspspVsSpFVGLlLcNscLPpssHGHVILus.suPlLlYQISSoEsRlLsshsupplPs.sss-ltpYLcssVtPplPccLpsSFhpAl-cu.plRsMPNpaLPAs.sss...pGlllLGDAhNMRHPLTGGGMTVuLsDllLLp+LLpPl...DLsDcpplschlpo.FahtRKshsu.llNTLuhALYpLFsAsscph+.tLcpGCFcYhphGG.ClsGPluLLuGl.P+PhhLhtHFFuVAlYulhp.hhsts.hhhPhulh	...................................................................................................................................AsLTllsDGhhSp....hR..........+..p..lh....s............p.....s.........p.....l.......S..p....F.l.....Gh......l..........s.........s...........h.....P...........h...........s......p........+.G...c.V.l.....L.u.......s...s....s.................Pl......L.hY.p.I.u..s.........p...E.....sR.h......L.l.D..l....s......p..............h.P..s.................p......h.p..p....a..hpp...h..l.......h......P.p...l......P...t..p...l..p.....s.Fh....t...A....l...p......p....u....p..........l.R...o....M.....P..N...p.h....h....P...s...s...........tp........G....hl.llGDAhNMRHPLTGG.GMTVAhsDlll....L....p.p.LL..p.sh...................sL.....t........D.........t..t.........t..l..h...p..h..h.p....p....F.aht.R.K.s....h.s..o..slNhL..A..t.A...LY.pl..Fu.....A.s..................sp...............p.h....+.thppuCFcYhphGG.hssGPluL.Lu.Gl......spP.h.LhhHFFuVAhaulhhhh.h...s.....................................................................................	0	73	152	207
+8324	PF08492	SRP72		SRP72 RNA-binding domain	Zwieb C, Rosenblad MA, Bateman A	anon	Pfam-B_7529 (Release 18.0)	Domain	This region has been identified as the binding site of the SRP72 protein to SRP RNA [1].	25.00	25.00	25.10	26.10	23.50	24.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.43	0.72	-3.60	19	306	2009-01-15 18:05:59	2005-09-06 16:14:07	7	56	261	0	211	304	1	65.40	35	10.29	CHANGED	uupthpppuspt...................................pppc...++KRKs+.hPKsa...s.sshpP.........DPERWLPh+-RSsYRs	..............................................ts...............t............................pthpppc.t...K+KRKs+..LP..Ksa........c.Ps..hsP.........DPERWLPh+..-RSsYRs.....	0	70	114	173
+8325	PF08493	AflR		Aflatoxin regulatory protein	Wuster A	anon	Pfam-B_2081 (release 18.0)	Family	This domain is found in the aflatoxin regulatory protein (AflR) which is involved in the regulation of the biosynthesis of aflatoxin in the fungal genus Aspergillus [1].  It occurs together with the fungal Zn(2)-Cys(6) binuclear cluster domain (Pfam:PF00172).	20.80	20.80	20.90	20.80	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.88	0.70	-5.36	5	174	2009-01-15 18:05:59	2005-09-06 19:28:07	5	4	87	0	46	171	1	201.60	32	56.62	CHANGED	GlssPsTsSoPsh.PAsTsAsTTSostPpssspupPsu.p.........PPlsTP...hTPssTSusSPchsp.QSPPspsElWGuhLSPssSs.tsoDLSSLlSVsoDFGsLFuSl.ss.L..pDGsDAD.hhAcuhGsL.sA.hsVuosMpDlFssuAspPPpSscsocsh......CLSlsL-TLp+LFPcAPlGCQ..+sDuE-SSu+LsTIESVISDNKcAhDTlpsIL-CsCAQDGYlLSLVSLIVLKVLGWYlAAARsQsouTscsGshsp-outcSRRsSSSSF......EEcVLH	..................................................................................................................................................................................................................................................................................tP....o....st.sSsh.sp...pSPP...........-h.s..Luss.hus..pssL....SS.L..olso.....pFut.......ht.Sh................cu.cs-...h.A......huuL....s......A.....s.uo.h..s.....h...tsAs.ss.ps....p.hs..................C.hslsLphLhpLa.s....p.ushs...Cp.............hsstp....ss.s.s......p.hhT.....h-....VlpsNKpsh-slpplLsC.s.C..up.Dthlh..hhs.hhh.+llthY.........ss...ht............................................................................................	0	8	26	42
+8326	PF08494	DEAD_assoc		DEAD/H associated	Wuster A	anon	Pfam-B_4150 (release 18.0)	Family	This domain is found in ATP-dependent helicases as well as a number of hypothetical proteins together with the helicase conserved C-terminal domain (Pfam:PF00270) and the Pfam:PF00271 domain.	20.20	20.20	26.50	25.30	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.95	0.71	-4.57	178	1433	2009-01-15 18:05:59	2005-09-06 19:34:35	6	13	1220	0	512	1383	597	187.00	30	15.93	CHANGED	hlPsscplllEph...ptt...stpllhashhG+psppsLuhllut+lscphshslshsssDYuhhlhsspp......................htc.....lhp.......-plpc...hlppslspotlh+p+FRpsAthuGll.+ph..Gt.phsspp.phsushLhps.h...............ct.ss.p.llppshcEshpchhDlsplpphLc+lppu..clplht...hspsSPhAh	................................h.lPsscpLllEphh....chu....caplll+ushG+plppshuhhlutRlppths.h.shs...hsusD.Glslphscs................................sp.shsp........lat.h.........s-pltp......hlpptl.ssSsLhttRFRcsAspuhLls+ptP.G+.c.pshh........Qp....phpustLlcl..t.................pth.P-asllhEohREsLp-hhDlstLtcllp+.lptu....clpltp....sspPSPhA.......................................	1	148	309	423
+8327	PF08495	FIST	DUF1745; 	FIST N domain	Borziak K	anon	Borziak K	Domain	The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [1].	22.10	22.10	22.20	22.10	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.06	0.71	-5.17	138	1150	2009-01-15 18:05:59	2005-09-06 19:37:04	5	35	807	0	415	1000	182	190.60	18	40.54	CHANGED	psslll.lFsosp..astpt..lhptlppths.sstllGCoouGtlss.............ts.sshulslhsh....sssthpshshhh..hs....sshpsutpthpphhpshttt..............................hhllhsDGhssstp...........pllpul.......ptthsslslhGG.AuDshthppohlhs..s........spshps........uslsshlps..............s.hphtshhspGapPh.utthhlTcu..cpphlhElsscP	................................................................................................................................hhh.haso.p...hs.p.h....lhptlp...pths..sstllGsoosu.lss.............................tt.sp.slsl..h..th...ssst..h....p.sh.th.hh......hpp.....s...h...ts.u..t..phhpphhpphtt..............................thhllhhDu.h.ssppp..............tllpsl.......p.tthss..sslhG..G....s....A.us...s..h.....t...h.....p...p....s.h.lht...s....................sphhps...........usl..s.lhlts.............s..hphtshhsp..sa..p.Ph....u.p......hhVTpu...csphlhElsspP................................................	0	135	287	368
+8328	PF08496	Peptidase_S49_N		Peptidase family S49 N-terminal	Wuster A	anon	Pfam-B_4027 (release 18.0)	Family	This domain is found to the N-terminus of bacterial signal peptidases of the S49 family (Pfam:PF01343) [1,2].	22.70	22.70	22.70	22.70	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.84	0.71	-4.43	68	1104	2012-10-02 13:07:06	2005-09-06 19:40:42	5	6	1078	0	169	648	164	149.80	52	44.51	CHANGED	MEFLh-YGLFLAKslTlVlAIlsllshlhuhsp+p+..tpc...GcLclscLsEpYcchccplcttllsccphKthcKppKKpcKt..cpKtpcpt.pt.....................+s+laVLDFcGsIcAs-VsuLREEIoAlLulApsp.DEVLlRLESuGGhVHGYGLAASQL	......................................................MEhLs-YGLFL..AKlVTVVlAIuslshlIls..h..s..pRp+...tp+.......GELclssLoEpY+Eh+-.cLtssL.h-pcptKthcKupKKc.c.Kp-sKutKt.chK.ut..................................sp..pKPRlaVLDFKGShD....A...+EVsSLREEITAlLAsA+sp..DcVlLRLESPGGhVHGYGLAASQL.......................................	0	45	79	128
+8329	PF08497	Radical_SAM_N		Radical SAM N-terminal	Wuster A	anon	Pfam-B_2018 (release 18.0)	Family	This domain tends to occur to the N-terminus of the Pfam:PF04055 domain in hypothetical bacterial proteins.	25.00	25.00	28.30	27.70	22.80	21.70	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-12.02	0.70	-5.49	100	1422	2009-01-15 18:05:59	2005-09-06 19:45:10	5	3	1388	0	288	1078	179	328.40	58	47.65	CHANGED	FLPho+cEMcphGWDphDlIlVTGDAYVDHPSFGhAlIGRlLEupGaRVGIIuQPDW+ss-..sFptLG+PpLFFGVoAGNMDSMVN+YTus+KhRp-DAYTPGG..........csG+RPDRAslVYop+h+EAa.p-l..PlllGGIEASLRRlAHYDYWSDKVRRSlLhDS+ADLLlYGMuE+sllElAc+Ls..........sG..cslps..lpsIRGTuahtpph.........................................................................................................sts...............pshlcLPSaEcVpsD+hhYAcA.+lhatEssPhsu+sLlQtHGs....R........hlhhNPPshPLo...........pcEhDtVYsLPYsRssHPsY........tct.tIPAh-hI+FS	.........................FLPhSRcEM-.pLGW.DuCDlIlVTGDAYVDHPSFGMAIlGRhLEAQGFRVGIIAQPDW...poc.-....DFh+LG+PsLFFGVTAGNMDSMlNRYTA-++lR+DDAYTPss...........huGKRPDRAolVYoQRC+EAa.K.D..V..P.VlLGGIEASLRRhAHYDYWSDpVRRSlLlDSKADhLhaGNGERslVEVA+RLA.................tG.E.s..Isp..........I....pD.....lRsTAhhs+cs...th..h.sp....................................................................................................................h...t...t.shc......cshlhLPSaEcVp....s....D...........K....lLYAHAsRllHpETNPhs.ARALhQ+H.G-.......R........hVWlNPPslPLo...........TEEMDpVFuLPYp.RlPHPsY........Gss.+IPAa-MI+FS....................................................	0	95	193	245
+8330	PF08498	Sterol_MT_C		Sterol methyltransferase C-terminal	Wuster A	anon	Pfam-B_3143 (release 18.0)	Family	This domain is found to the C-terminus of a methyltransferase domain (Pfam:PF08241) in fungal and plant sterol methyltransferases [1].	21.70	21.70	22.60	22.40	21.60	19.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.92	0.72	-4.02	17	347	2009-09-11 17:15:18	2005-09-06 19:48:55	5	6	196	0	227	339	4	65.40	42	18.38	CHANGED	hhohaRhotlGRhlTpshVthlEplGLAPpGSp+VsssLEpAAcuLVtGG+cclFTPMaLaVARKPt	............hohhRhothGRhhs+thltsLEhlGlAPcGopcsschLtpAA-sLVtGGcpplFTPMahhluRKP.....	0	72	142	197
+8331	PF08499	PDEase_I_N		3'5'-cyclic nucleotide phosphodiesterase N-terminal	Wuster A	anon	Pfam-B_3045 (release 18.0)	Family	This domain is found to the N-terminus of the calcium/calmodulin-dependent 3'5'-cyclic nucleotide phosphodiesterase domain (Pfam:PF00233).	21.60	21.60	22.60	24.90	20.50	21.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.51	0.72	-4.07	6	248	2009-09-11 06:25:11	2005-09-06 19:54:19	7	5	83	0	129	240	0	59.40	69	10.83	CHANGED	RLhDpDDELt-lps-oVPsE..VR-WLASTFTRps...ttpsc-KP+F+SlspulpuGIFs-+	..................RLLDTEDELS-lQoDuVPSE..VRDWLASTFTRQMu..hhtR+uE.E..KP+FRSIVHAVQAGIFVER............	0	21	30	75
+8332	PF08500	Tombus_P33		Tombusvirus p33 	Wuster A	anon	Pfam-B_2139 (release 18.0)	Family	Tombusviruses, which replicate in a wide range of plant hosts, replicate with the help of viral replicase protein including the overlapping p33 and p92 proteins which contain the domain described here [1].	21.80	21.80	22.90	22.10	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.86	0.71	-4.44	10	116	2009-01-15 18:05:59	2005-09-06 20:20:20	5	3	28	0	0	123	0	145.10	43	31.33	CHANGED	plslsshhh.ss.......LP...Rthlpphcphp-Ah-phs-DD-ssssl.h...p..hh.s.....Psschp+lVtps...RRs+YAsKlAtsA+uKVGLLKNocANcLVYQRVhl-.McpcsVRasDRstlLPLAVsA.CFl............pP-uV-EsppllGuS	...............................................................................hhthhh.......lh..s.......hP...Rthhp.hhhhhptpshhps-c-ss-sl.hp......c..hs.Dh.........sso+hTKhltuo...RRtsYAs+lApVARAKVGhLKNo.tNRLlYQRlhl-hMcccsVRhscpcshlPLAlus.CFl.............s-shEEptAlhGs...........................	0	0	0	0
+8333	PF08501	Shikimate_dh_N		Shikimate dehydrogenase substrate binding domain	Bateman A	anon	Pfam-B_99 (release 18.0)	Domain	This domain is the substrate binding domain of shikimate dehydrogenase [1].	21.30	21.30	21.40	21.40	21.20	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.64	0.72	-3.92	40	6595	2009-01-15 18:05:59	2005-09-07 11:19:50	6	52	4461	89	1540	4807	2370	81.30	34	25.44	CHANGED	llGpPlp.HShSPhlHNtha....pphGl.sssYhsh-ls........-shpsh.lptlcs....shtGhNVTlPaKpplhshlDclsspActlGAVNTl	.......................lhGpPlt.HShSPhhHsthh................p.p..hG....l..s..h.s.Yh..sh.pls...............p.sh.s.ps..lp..s..hps........hshpGhNVTh..PaK..p.psh......s......h..h....D...c....los.pAph..lGAV.NTl................	2	443	935	1297
+8334	PF08502	LeuA_dimer		LeuA allosteric (dimerisation) domain	Bateman A	anon	Pfam-B_223 (release 18.0)	Domain	This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway [1].\	     This domain, is an internally duplicated structure with a novel fold [1]. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich [1].	24.90	24.90	24.90	24.90	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.61	0.71	-4.36	57	5003	2009-01-15 18:05:59	2005-09-07 12:07:43	5	10	3771	14	1392	3984	3575	133.80	27	25.84	CHANGED	cls-tDlhslhppphtp......................tp.phhcLpphpVhssst.........hssAsVplph....sGch......hptsupGsGPV-AhhpAlp+hlsh...pl...cLh-YplpulssG.sDA.upspVplp.....pc.sph..............hpGhGsssDIlpASscAhlsulNphh	...............................................................plh-t-l.sLhp.p.phhp......................tp...phacLp..p..h...p.l....p...ssss................thss...As..V.p.lps..............sGct....................................hptsupG.s.GPV-AlhpAlpchhsh..............sh.........cLhc......Ypl.pu.l..........s.............p..............G.....s....D.........A......h.u...p...shlplp...................ts..Gcp..........................................hpG.sGlssDIlpAShcAhlsAlNph.h......................	0	459	946	1204
+8335	PF08503	DapH_N	DapD_N;	Tetrahydrodipicolinate succinyltransferase N-terminal	Wuster A	anon	Pfam-B_4065 (release 18.0)	Family	This domain is found at the N-terminus of tetrahydrodipicolinate N-succinyltransferase (DapH) which catalyses the acylation of L-2-amino-6-oxopimelate to 2-N-succinyl-6-oxopimelate in the meso-diaminopimelate/lysine biosynthetic pathway of bacteria, blue-green algae, and plants [1]. The N-terminal domain as defined here contains three alpha-helices and two twisted hairpin loops [2].	21.70	21.70	22.70	22.00	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.62	0.72	-3.86	38	1077	2009-01-15 18:05:59	2005-09-08 09:31:38	5	7	1060	10	128	492	4	81.20	49	34.92	CHANGED	hDApEIIpaIpsuKKpTPVKVYlcGs.Lpslsh..sslcsFsssphtllFG-ap-lcshL-tNpcpIccYclEsDpRNSAlPLLDl	....................hsApEIIpaIusAcKpTPVKVYlcG....p....Lps..lsh...p....olpsF.......Gstp.tVlFG-Wc-lcPhL-s.spphpDYhlEpDtRNSAlPLLDh............	0	42	75	101
+8336	PF08504	RunxI		Runx inhibition domain	Wuster A	anon	Pfam-B_4085 (release 18.0)	Family	This domain lies to the C-terminus of Runx-related transcription factors and homologous proteins (AML, CBF-alpha, PEBP2).  Its function might be to interact with functional cofactors [1].	20.50	20.50	59.70	59.70	18.00	17.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.64	0.72	-3.57	9	243	2009-01-15 18:05:59	2005-09-08 09:34:32	6	4	51	0	82	197	0	96.50	68	23.14	CHANGED	P.sos.QsQ.....sGsFQosSoPYaLYYGouoGSYQFSMlssG....GG-RSPoRhLssC.TuASTGu......sLhNPs.LssQsD...GVEu-GSHSN.........SPTuhssssRhDEuVWRPY	........................................PGSo.QsQSGPFQoSSoPY.LYYGo.SSG.SY.QFSMVs.......GG-RSPoRML.PPC..TsuSsGo......sLlNPs.LPsQsD...GV-..ADGSHSN.........SPTshssuGRhDEuVWRPY.............	0	4	10	33
+8337	PF08505	MMR1	DSL1;	Mitochondrial Myo2 receptor-related protein	Mistry J, Wood V	anon	manual	Family	Myo2p, a class V myosin, is essential for mitochondrial distribution, class V being vital for organelle distribution in S. cerevisiae. It is the myosin essential for mitochondrial distribution. The established mechanism for distribution of cellular components by class V myosins is that they interact with the cargo at the C-terminal tail domain and transport it along the actin cytoskeleton using the N-terminal motor domain. Cargo-specific myosin receptors act as the link between the myosin tail and cargo. Myo2 binds with MMR1 (mitochondrial Myo2p receptor-related 1), the receptor on cargo, via the C-terminal domain.	23.00	23.00	40.10	40.30	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.84	0.70	-4.32	7	25	2009-09-11 00:16:20	2005-09-08 10:12:00	5	1	24	0	13	22	0	232.40	53	47.39	CHANGED	KLuEhoRsGRSpp...+psS......DohRSsSPhRhthhss............sPKMLKPEYl...............S..ssshsLlSuhltpu..tptsp................................p.tts.s..ss.tts...t.....hhppsh....tQhR.p.............ph.tstpppppps.phpptpsppptpt...lpstptshss.sh.t..o......s.stphpp..tt.....p...hp...sSssuuss.s.hp.pph.pthpls.slPsDcNGFV......sspspR.SaISusuoD.h-.-...Whs	.....KLSELSRGGRSKQ......RRGS......DTMRSVSPIRFQFLNN.................TPKMLKPEYL....................SQTTS..NLPLLSALLKNS..KKTTS................................EuQNSNPDPLNIEKNIIKQS.....IKDKL....EQLRoS...............................EolupVQ+KE+sssSaE...A..css.AEE...sllhpNsEuhLsShs......................PVPAoshcsPpsH..spcsEccuhRlVSuuSTpslS.sElNELPKDLNLD.sLPTDpNGFVQhs.....................tsNNNNNRYSFISSTSTD.YEsE...WpD.....	0	1	4	10
+8338	PF08506	Cse1		Cse1	Mistry J, Wood V	anon	Pfam-B_9217 (release 17.0)	Domain	This domain is present in Cse1 nuclear export receptor proteins. Cse1 mediates the nuclear export of importin alpha.  This domain contains HEAT repeats [1].	20.30	20.30	20.50	20.40	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.37	0.70	-5.89	15	650	2012-10-11 20:01:01	2005-09-08 11:24:21	5	15	291	3	453	616	8	300.30	24	31.98	CHANGED	IFKRWRPLF+Ss-LalEIKhVLDpFupPalsLhpsssphlps..sp.sscspLpllFcsLlLlsKlaYDLNsQDlPEFFEDNMpshMsha++YLohsN.PLL-..s---EAulL-+lKuuICEhlpLYsp+Y-E-FpPalppFlpslWsLLso.sospsKYDlLVS+ALpFLTuVAchs+YtplFss-ssLppIsEclllPNlsLR-uDEELFED-PlEYIRRDLEGSDsDTRRRAAsDhL+pLpccaEuhVTsllhpalpphLspYtpsPssNWKtKDsAIYLaoSlAsKGssTps.GVToT.NsLVsls-FFsppIhPDLh.sssssaPILKsDAIKYlasFRsQLsKpQLlplhPlLhpaLtssshVVaTYAAhsI	.......................................................................................................................................................................................................................................................................................................................t......hh+laash..s..s...lP.....h..h..p..p..p..h...t.th....h....t......hhphlp......h.ss.................p.............p.......pp..p..s.......h............hh+..t..........h.hc.....h....t....h........a...........h.......p........+.....Y............t..........-.....................h.......t............hl...............p........a........h....ts.h.h.p.....l.........L....hp...h....p.................p..........c...................h.........l.....s.....ps.....l...p.a.L.s.t..l.sp...t.s..........p..a...t.............h..a.p.t..psplpplhp..c...lIhPshshp-p...D.ElaE--P.EYIR+...c.h....-...............s..p.D.h.s....o..cpAAss.hlp.sL...s...c........p.hc.p..lhthh....h....talpph..Lsp............h...t..t....s.....s..s...t..s...........a..+.p...................K........Ds..AlallsoLA.hh............................h...hh.t.lh.........ch............................................................h...........stsh..hh..a..................................................................................................................................................................	0	138	231	354
+8339	PF08507	COPI_assoc		COPI associated protein	Mistry J, Wood V	anon	manual	Family	Proteins in this family colocalise with COPI vesicle coat proteins [1].	23.80	23.80	23.90	24.20	23.60	23.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.96	0.71	-4.49	24	296	2009-01-15 18:05:59	2005-09-08 11:31:58	5	12	163	0	225	274	1	136.70	20	72.33	CHANGED	chssha..+hlNlssGslhlluGlsphh.........shp.....shllulYhIhhGlhlhhLEa..phP.......lhcYuSFhaSalGRGlFYlhlGsllhts.......shhphlsGhllhllGlhYlsLcahsslp...Ps..sh.........+psshshshpp.....................l	...............................................................h....hh.+lhslssus.l.hll....u.u...l.hphh..........hshp..........shllulYhl....lFulh...lshhEhph.h........................lhcahsFLh....sahGRGlhYlF........lG.slhhst........................thhphlsGhh.lhhhG..lh.alsl.thh..h..............................................h..........................................................	0	111	165	207
+8340	PF08508	DUF1746		Fungal domain of unknown function (DUF1746)	Mistry J, Wood V	anon	manual	Domain	This is a fungal domain of unknown function.	22.30	22.30	22.60	24.60	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.52	0.71	-4.16	14	96	2009-01-15 18:05:59	2005-09-08 11:59:42	5	2	94	0	74	99	0	113.30	37	32.54	CHANGED	sLDhLhashlshlYahDsShlhLhlRuhsQh.hhsPc.................ss.hc.stspshlhsllhu.NlhCllhHhhhuhspuu-u..scGYLHGGlhIsFIGp+sPhS+hcllhhDllllslQllh	......sLDhLhas.LsslYYhDCShhpahlRulsQhhahoPK..................sssht.stspshlhslhhs.Nl..hChlhHhhhuhPpuuEs.........oRGYLHGGlhIDFIGQ+s....PsS+hcLlhlDllllslQllM.................	1	16	38	61
+8341	PF08509	Ad_cyc_g-alpha		Adenylate cyclase G-alpha binding domain	Mistry J, Wood V	anon	manual	Domain	This fungal domain is found in adenylate cyclase and interacts with the alpha subunit of heterotrimeric G proteins [1].	20.10	20.10	20.10	20.40	19.60	20.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.46	0.72	-4.63	19	100	2009-01-15 18:05:59	2005-09-08 12:50:02	6	46	95	0	57	104	0	51.20	30	2.63	CHANGED	scshsPscc.....psssla+LDTNLscMEGIlocP.PhoPhDsshhsstps.cppp	....................tt.sssspt.........ssssla+LDTNLs-M-GIl..spP.PhoPhDsshh.sht.................	0	9	27	45
+8342	PF08510	PIG-P		PIG-P	Mistry J	anon	manual	Family	PIG-P (phosphatidylinositol N-acetylglucosaminyltransferase subunit P) is an enzyme involved in GPI anchor biosynthesis [1].	29.90	29.90	32.10	32.00	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.66	0.71	-4.50	38	303	2009-09-13 01:51:06	2005-09-08 13:13:10	7	8	260	0	208	294	0	126.70	31	50.41	CHANGED	sppchYGFshalhoplsallYllWualPcphLcp.l..................slsYaPs+aWAlAlPsallh.shlhsalshhhhNh.hhT.PLsulps.........lsDphuphtstpphsphpt..t................................................................hsslhDlslstVsclLYt	........phthYGFlhalsothsallYllWualPpsaLpp.l...................Gl.s....YaPs+aWAlAlPsallh.sllhsalhhhuhNh.hhTsP..lsS...lps.........lsDphup.hth.pp..h.tp..t.................................................................................................................................................................................................hsslhDlslstVschha......................................................................	0	62	114	169
+8343	PF08511	COQ9		COQ9	Mistry J, Wood V	anon	manual	Domain	COQ9 is an enzyme that is required for the biosynthesis of coenzyme Q [1].  It may either catalyse a reaction in the coenzyme Q biosynthetic pathway or have a regulatory role.	20.50	20.50	20.80	20.60	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.48	0.72	-4.47	70	470	2009-09-11 14:22:47	2005-09-08 13:40:06	6	6	434	2	244	450	340	77.20	34	29.11	CHANGED	Ppssspuh+hlaphuDsIWphsGDpSs.DhsWYTKRssLuulYuuThLaa........lsDsStsapsThtFL-RRIcsVhphpch+s	...............................P.phstuhp.lhphsDsIWhhAG........D.pS.s.Dh...sWYTKRssLuulYsoo..L.ah........lpDpS..satcThpFl-cRlpc.lhp.htph..h.................................................	1	74	140	193
+8344	PF08512	Rtt106	DUF1747; 	Histone chaperone Rttp106-like	Mistry J, Wood V	anon	manual	Domain	This family includes Rttp106, a histone chaperone involved in heterochromatin-mediated silencing [1]. This domain belongs to the Pleckstrin homology domain superfamily.	25.50	24.60	26.40	25.60	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-10.20	0.72	-4.00	156	861	2012-10-04 00:02:25	2005-09-08 15:06:29	7	18	317	14	611	854	9	92.10	27	12.65	CHANGED	hhuVpsphtsspG...h...LaPlpc......slla.hcKPhhhlshs-.IptlpapRh.......sshsp+oFDhslhh.+............s.........ttshpFssIspp.-hsslcp.alpppslphpst	........................h..ul.sp.t.ssu...hLhPhsc......ulla.hcp...Pshhlsh--.Iph......lpapRh........shst+sFDhslsh..K..........................s................tpsshphssI..........spp.phs.....slc-.alsspslphpp.h.................	0	210	346	514
+8345	PF08513	LisH		LisH	Mistry J, Wood V	anon	Pfam-B_8344 (release 17.0)	Domain	The LisH (lis homology) domain mediates protein dimerisation and tetramerisation.  The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes.  It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.66	0.73	-6.83	0.73	-4.03	58	1365	2009-01-15 18:05:59	2005-09-08 15:43:56	6	33	318	20	874	1281	4	26.50	35	4.96	CHANGED	ppLNtllhcYLhcpGapcoApsFtpEu	......plNhllhcYLhcpGapcoApsFtpEu....	0	243	438	680
+8346	PF08514	STAG		STAG domain  	Mistry J, Wood V	anon	Pfam-B_4766 (release 17.0)	Family	STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organisms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version [1].	25.00	25.00	25.60	25.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.41	0.71	-4.39	9	489	2009-01-15 18:05:59	2005-09-08 16:00:32	6	8	266	0	290	449	3	117.10	42	10.50	CHANGED	EcsuDYPLssps.paKpF+ssLssFlpsLVppsp.tuhLYDs.....slhDslhshlsuLSsSpsRsaRHTATlsuhplhTuLlsVAhpLspp+-ssp+Ql.EAE+pKtpss+u...Rl-uLhpp....tpc	...............................css-YPLhht.u.....p..aKcF+.....ssFs-.FlpsLlp.pCp..hSllY..Dp......................hhM-sllohLou.LS.....s.S.plRuFRHTuT....L..s..Ah.+.LhTuLVsVA.l.sLoh....p.h.-..sspR...Qh....EAE.+.pKh.hs.p+u.........Rl-.L.p+ht...............................	0	75	127	214
+8347	PF08515	TGF_beta_GS		Transforming growth factor beta type I GS-motif	Wuster A	anon	Pfam-B_630 (release 18.0)	Family	This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation.  The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain.  Point mutations in the GS motif modify the signaling ability of the type I receptor [1].	20.40	20.40	20.50	21.00	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.75	0.72	-7.15	0.72	-4.61	28	639	2009-01-15 18:05:59	2005-09-08 18:27:40	7	10	112	65	307	548	0	28.20	68	5.73	CHANGED	pslpDll-....soSG..SGS.GLPhLVQRTlAR	........poLpDLlp...p.soSG..SGS..GLPLLVQRTlAR..	0	55	82	176
+8348	PF08516	ADAM_CR		ADAM cysteine-rich	Wuster A	anon	Pfam-B_197 (release 18.0)	Family	ADAMs are membrane-anchored proteases that proteolytically modify cell surface and extracellular matrix (ECM) in order to alter cell behaviour.  It has been shown that the cysteine-rich domain of ADAM13 regulates the protein's metalloprotease activity [1].	20.60	20.60	20.60	22.60	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.47	0.71	-4.04	68	1660	2009-01-15 18:05:59	2005-09-08 18:30:05	7	30	158	17	695	1511	0	112.40	31	15.88	CHANGED	sGpPCps.stuYCYsGpC.shspQCpplFGtsAcsAspsCapclNppGsca.GpCGpp...ss...paltCptpDlhCG+LhCpsssphshh.t.....shh.s.h.....p.shhChuhcht.hs........sssDhGhV	..........................sGpPC.p.s....s.....p..uYCYsGpC..s.h.spQCp..plaG......s...A.ps..A....schCapclN.....p......p..G..sp..............a.GsCGpp.....ss..............pahtC...........s..t..pDs.hCG+L.Cpsspp.h.Ph.h...t...p.........tsh...h.....h...........p...th.Chuhth....t...........................................................	0	75	106	268
+8349	PF08517	AXH		Ataxin-1 and HBP1 module (AXH)	Wuster A	anon	Pfam-B_5484 (release 18.0)	Family	AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1).  ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans.  The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression [1].	33.00	33.00	33.50	34.10	31.60	32.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.48	0.71	-3.91	10	201	2009-09-13 12:05:04	2005-09-08 18:31:55	7	7	75	8	118	189	14	116.40	43	20.73	CHANGED	FlKGohlpltcGphK+VEDlpoEDFlpSApcSsDh+lssS............sVp+I-ssu.u.ullpLTFssGs.ccuhlslEspl-HPFFVhs+GWSSCsPshTlppaGLsCpcLpVGDVCLsLshp	............................FhKGohlpht....s..G.....phK+.lcDlt.sEDFhpSsE.hssshclssu...................................................hVs+l-ssp....s............uhlhL...pFss.Gp..ccup.lolEshl-HPFF.VhspGWSShpPphTsthauLPCpcLpVGDV.Cls.sh.h...........	0	22	35	69
+8350	PF08518	GIT_SHD		Spa2 homology domain (SHD) of GIT	Wuster A	anon	Pfam-B_13873 (release 18.0)	Family	GIT proteins are signaling integrators with GTPase-activating function which may be involved in the organisation of the cytoskeletal matrix assembled at active zones (CAZ).  The function of the CAZ might be to define sites of neurotransmitter release.  Mutations in the Spa2 homology domain (SHD) domain of GIT1 described here interfere with the association of GIT1 with Piccolo, beta-PIX, and focal adhesion kinase [1].	21.10	21.10	21.60	21.20	18.80	20.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.81	0.72	-6.99	0.72	-4.59	16	634	2009-01-15 18:05:59	2005-09-08 18:34:00	6	17	202	0	362	665	2	30.50	48	6.87	CHANGED	ARpKLt+LSpppFp-LssDVhsElcRRpppu	....ARpKLtpLssppFp-LshDVasElcRRppt.....	0	92	167	267
+8351	PF08519	RFC1		Replication factor RFC1 C terminal domain	Wood V, Mistry J	anon	Pfam-B_5399 (release 17.0)	Domain	This is the C terminal domain of replication factor C, RFC1.  RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo [1][2].	20.70	20.70	21.30	20.80	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.92	0.71	-4.47	48	368	2009-01-15 18:05:59	2005-09-09 09:02:23	7	16	300	1	251	360	30	150.00	36	16.87	CHANGED	IScGDllschI+uspp..WSLhPhaulhSoVhPuphltGp....hss.phs........FsuWLGpNSppsKhpRhlpElphHhphpo....sss+pplphsYl.shlhpp.LhpPLhppst-.....ulpcllphM-pYhLo+EDh.-sIh-ls......hssppshhpplsoplKuAFTRtYNp	................IS-GDLV-phI+u.........spp..WSLhPsp..AlhSoV.hPup.hhtGp........hss..h.s........FsuW.LGpNSppuKh...pRllpElphHhpl+s....sus+pplp.hsYl.shLhpt.Ll.......pPLt..p....pG.t-......................ulpcVlphMD..sYhLs+EDa.DsIhElu.......hss.pss.hs.plsspsKuAFTRtYNp.............................	0	93	146	211
+8352	PF08520	DUF1748		Fungal protein of unknown function (DUF1748)	Mistry J, Wood V	anon	manual	Family	This is a family of fungal proteins of unknown function.	20.00	20.00	21.70	30.40	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.30	0.72	-4.33	19	138	2009-01-15 18:05:59	2005-09-09 11:04:59	5	2	100	0	108	143	0	70.70	38	74.67	CHANGED	lG+lhHhuhDhsLlSshLAGl+RsTGLo.............................ch-..thpspp.l+salc+YLshGEh.laDpoVAh.suoSsaFcRp	..................................................................lG+lsHauhDhlLl....SshLAGl+RsTGLo..........................................................................p..hs...hhpsps...lcpalcpYLshGEh.lhDpoVAh.hus.SuaFcRp..................................	0	36	70	100
+8353	PF08521	2CSK_N		Two-component sensor kinase N-terminal	Wuster A	anon	Pfam-B_4164 (release 18.0)	Family	This domain is found in bacterial two-component sensor kinases towards the N-terminus.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.81	0.71	-4.69	111	966	2009-01-15 18:05:59	2005-09-09 16:15:29	5	12	521	0	332	893	127	146.10	28	30.67	CHANGED	sLhllhslshhh....sahhAppsAspsaDRsLhuuApslucplph.p....sGp.lplclPhsAh-hlpsss...pD+laYpVhss..............sGphloGh.s-.LPhss....ssssp..........pstaaDsp....a.pGpslRhsslhp......l.t.....s..s...t.lhVpVAcThpsRpthupclh	.....................................PLhlLhshushh....sYhhAhpsAspsaDRsLhuu.Apslu.....cpl...ph...p.......sGp...l....p....l....slPh...sAL-.hh.ptss........sDp.laYpVhss...............sG...chlu.......G...s-.L.Phss.......sssstt......................hsh.aa-sp......a..cG....p..s..lRlAtlhp.............................................slsps......shs............thshltVAEThpsRptlAppl...........................................................................	0	37	144	239
+8354	PF08522	DUF1735		Domain of unknown function (DUF1735)	Wuster A	anon	Pfam-B_2199 (release 18.0)	Family	This domain of unknown function is found in a number of bacterial proteins including acylhydrolases.	21.40	21.40	21.40	21.70	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.97	0.72	-3.60	101	771	2009-01-15 18:05:59	2005-09-09 16:19:03	5	17	106	11	91	680	4	88.10	20	24.59	CHANGED	sspshs.lpl.slDtshlctYN....pp.....pss.sY.phLPps...hYshss..plslpsG..pt.hus.hslphpst.........sh.p.sppYlLPlpls.ssss........tlsps	..............................s.tpshp.lpl..th...Ds....s....h....ls....pYN.........tp.........pss...sY.phLPps...........hYs.l.ss................p........lsl..psG.........ph...hus..lplplpst...............tth.stsppYlLPlpls.ssss.........s.........................	0	57	80	91
+8355	PF08523	MBF1		Multiprotein bridging factor 1	Wuster A	anon	Pfam-B_4141 (release 18.0)	Family	This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2.  It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex [2]. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC [1].  The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants.\	     A helix-turn-helix motif (Pfam:PF01381) is found to its C-terminus.	22.20	22.20	22.70	22.70	21.00	21.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.25	0.72	-3.96	21	391	2009-01-15 18:05:59	2005-09-09 16:30:21	5	2	301	1	230	359	6	71.00	39	48.23	CHANGED	sDW-s.VsVlpK+......sP+sssh+sppslNuApRsGhslpTpKKasuGsNK....ssstspphsKLDc-T-.lphc+V	...............pDW-o.Vsl.lt++.......uPp.sssh+.scpAlNAApRp..GtslpTpKK.auuGsNK........psstspsssKLDc-TE.l+hc+V......................	0	71	126	190
+8356	PF08524	rRNA_processing		rRNA processing	Mistry J, Wood V	anon	manual	Domain	This is a family of proteins that are involved in rRNA processing [1].  In a localisation study they were found to localise to the nucleus and nucleolus [2]. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1 [3]. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli [4].	23.00	23.00	23.00	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.17	0.71	-4.41	7	187	2009-01-15 18:05:59	2005-09-13 09:14:14	6	3	165	0	123	167	0	123.90	23	64.94	CHANGED	Mutstptp..ptKKFT..+Ea....KsK-Ip+sLs++ARL+KpYhKsLccEGYth...PEcp.......p.+..........-s++hppKp+ls..E+tEhtKpRKRpQ+-chptphpcchEcIc...pKppEREp++cpLop+T+pGQPlMGP+INDLLDKIKpDp..Tp	..........................................................................ht............................................................................ptt.........................p..p...............................pp..p.p......c.t.pp...p.p....php.....E.chc.th+pc+...ctp+pchpcp.t...p.c.+cE...t...hc........ptppcRh..cp...p.chlsK+T++GQPlMssphchLLcKIpp....tt......................................	1	46	72	103
+8357	PF08525	OapA_N		Opacity-associated protein A N-terminal motif	Bateman A	anon	Bateman A	Motif	This family includes the Haemophilus influenzae opacity-associated protein. This protein is required for efficient nasopharyngeal mucosal colonisation, and its expression is associated with a distinctive transparent colony phenotype. OapA is thought to be a secreted protein, and its expression exhibits high-frequency phase variation [1,2]. This motif occurs at the N-terminus of these proteins. It contains a conserved histidine followed by a run of hydrophobic residues.	20.70	20.70	20.70	20.90	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.27	0.72	-4.07	45	1258	2009-01-15 18:05:59	2005-09-14 11:24:36	6	6	755	0	126	489	6	30.60	43	9.32	CHANGED	phhphLP+hH+hhlhslssllll.lllh....Pus	.......hhssLPhhHRhhlhhhsllhls.uhhh....P..........	0	9	34	81
+8358	PF08526	PAD_N		Protein-arginine deiminase (PAD) N-terminal domain	Mifsud W, Bateman A	anon	Pfam-B_2195 (release 6.4)	Domain	This family represents the N-terminal non-catalytic domain of protein-arginine deiminase. This domain has a cupredoxin-like fold.	25.00	25.00	29.00	28.20	24.30	19.60	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.39	0.71	-4.03	15	190	2009-01-15 18:05:59	2005-09-15 15:51:24	5	6	40	12	84	173	0	106.60	38	17.47	CHANGED	Mu.pphV+LShcpPT+AVCVlGsEhplDlpusAPcsspsFslpGSPGVplplstsss.psccssuss+WPLssss-llVsMsusSssssDsKVpVSYausppchPlupAVLYLT	............Ms.pphl+lshppsspAVCVlGsphhlDlhu...uAPpssp...oFslpuSssVplplshss..ppppss..upp+WPLsss.s-lhlsMsssSssh.sD.s..KVp...loY.Yupcpt.PlspAlLYLT................	0	5	6	18
+8359	PF08527	PAD_M		Protein-arginine deiminase (PAD) middle domain	Mifsud W, Bateman A	anon	Pfam-B_2195 (release 6.4)	Domain	This family represents the central non-catalytic domain of protein-arginine deiminase. This domain has an immunoglobulin-like fold.	20.00	20.00	30.30	28.60	19.90	17.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.06	0.71	-4.83	15	201	2009-09-10 21:19:31	2005-09-15 15:53:00	5	7	49	12	96	184	1	154.90	46	24.89	CHANGED	V-ISLDsDssRsGpV-+sps..cKpoWpWGPsGaGAILLVNCD+Dshtust............DpccsplhshcDLpDMS.MlLpspGPcsLhcsY+LVLHlSpSDuc+lRVFpupsst.............shpsYchVLGPpphoYpVthhsGppchpFYVEGLsFPDssFsGLlSlsVSLL-	......l-ISLDsDhsRsGpVccsps.....cKpsWsWGPpG.GAILLVNCD+D.sstp..s.t............Dspcpc.........lhs..........h.....p.....DLpD..MS.MlLpTpGPspLhs.sacLVLalStuDuc+lRVFpspss.....................sppYptVLG.p.....+hsatVthh....sG..pt-hpFaVEGLsFPDssFsGLlSlpVSLL-........................	0	8	11	27
+8360	PF08528	Whi5	Nrm1; 	Whi5 like	Mistry J, Wood V, Chahwan C, Finn RD	anon	manual	Motif	In metazoans, cyclin-dependent kinase(CDK) dependent phosphorylation of the retinoblastoma Tudor suppressor protein (Rb) alleviates repression of E2F and thereby activates G1/S transcription. The cell size regulator Whi5 appears to be an analogous target of CDK activity during G1 phase [1].	25.00	25.00	25.60	25.10	24.30	24.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.36	0.72	-6.59	0.72	-4.24	24	164	2009-01-15 18:05:59	2005-09-15 16:38:06	6	3	80	0	127	152	0	25.00	42	6.36	CHANGED	pL+sRLphAhaKspsG.pchoLscl	...pL+sRLshAhhKlpsGhpchoLscl..	0	31	71	109
+8361	PF08529	NusA_N		NusA N-terminal domain	Bateman A, Roth A	anon	Pfam-B_407 (Release 18.0)	Domain	This domain represents the RNA polymerase binding domain of NusA.	20.80	20.80	20.90	20.80	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.46	0.71	-4.12	161	4422	2009-09-13 23:45:58	2005-09-20 15:50:34	6	28	4355	5	970	2799	2484	119.80	35	27.93	CHANGED	El.lpslctlscEKsIs+-hlhcAlEpALhsAh......+Kp.a....s......ps.pslcVplDccoG-hclapphpVV..-c...........h.......cs..thplsLp-A...p.phsssh...pl..GDhl.p.pl..ssts..FGRIAAQsAKQVlhQ+l.REAERct	...............El.LtslcslppEKuls+-.hlh-AlEsALhsAh..........K+pa.............s.............pp.tsl+Vpls....c..c.oGc..hclap.p.hpV...V..--.............................Vp......ss...phEIo..LppA......p.......s..s..sh.....................pl..GD.hl..c.cl..ss..ts...FGRlAAQoAKQVIhQ+lREAERt.h...............	0	341	650	828
+8362	PF08530	PepX_C		X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	Bateman A	anon	Bateman A	Domain	This domain contains a beta sandwich domain.	20.70	20.70	20.80	23.00	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.12	0.70	-4.45	53	2418	2012-10-03 19:46:52	2005-09-20 16:49:51	5	23	1578	54	704	2136	679	229.10	17	35.97	CHANGED	Nsh.tshPsVph.sptssps...................................Wps.ssassspspt......phhLs.......t......sthshpttsshssshsh.tthhhss.....................................................tptsshsapotslscshplsGpsplcLplsssss.......ss.plsspLh-l......ssc.....................Gps....................plloc....Ghlplpt+p...p........................................ptlpPsphhslclcLpsosaphtsGcpLclhlsosshsthhhsssstp.hshshsp.........................................pLh	..................................................................................................................................p.P..V.h.h..p..s.tt......................................Wps.h.s..s..aPs......psp.................phaLs...................................s....t.....h.sh..p....t...t...t..sh.s.s.sh.t...........tthhhss.....................................................................................................................tptsshsah.s.sl.s....c..s.......h..clsGpsplcL...p.ls.s..ss.s...............................cs...slh.spLh-l......ssc.................................................Gts....................................thlop...........G..h.l.php...Rp.....p........................................p.lps.s..c..h.hp...lplc.L..s.s.saphptGcpLclslt.uo.s...h...s..h..hh.h.s..s.s....s..hp...hs.h.p.tp.......................................................................................................	0	207	463	615
+8363	PF08531	Bac_rhamnosid_N		Alpha-L-rhamnosidase N-terminal domain	Bateman A	anon	Pfam-B_8527 (release 8.0)	Domain	This family consists of bacterial rhamnosidase A and B enzymes. This domain is probably involved in substrate recognition.	25.00	25.00	25.00	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.73	25	876	2012-10-03 19:46:52	2005-09-20 16:50:02	5	42	361	2	288	895	96	166.90	27	18.23	CHANGED	+pltpARLYlouLGlYEhalNGc+VGDps.........LsPGaTsYc++l.YpTYDVTshLpc.G.cNslGlhVGsGWYssphsh........thp.pthYG.sc.ullupLclpat.DGppcsl.sTDsoW+ss.pGslhtusl....YsG..EsYDARt-.tsWspssaD..DstW....................tssph..............hshPp.stLtAp.ssPl+lsc	..............................................................ltpAplalouhG.......hY-hhl......N....G..p.+.V....G.c..ph.....................LsP.u.hTsY...p.................+................p......lhYp.TY.....DVT..shLpp.....G...pN..........s......lulhl...u.s.GW..ap..s.th.s............................pthhu....sp....s..shhspL.p.lpat.D.......Gs..p.p..h..l...so.........D.......s....o....W+s.......s...p...u.s....l...h.hssl......................asG.......E...p...Y..D..A..R..h..c............t........s....Ws....p..s...s...a..s........c....s..tW.....................................t.ss.h..................................h.t.....s...........l...........................................................................................................	0	134	224	270
+8364	PF08532	Glyco_hydro_42M		Beta-galactosidase trimerisation domain	Bateman A	anon	Pfam-B_2131 (release 5.4)	Domain	This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation [1].	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.22	0.70	-11.17	0.70	-5.17	27	1054	2012-10-03 00:28:14	2005-09-22 16:56:59	5	20	641	2	343	1020	170	197.10	26	29.29	CHANGED	AcVAl....laDa-shWAhc.p..Pp.pshp..........YhpplppaYcshhchGlslDlls.ss.-lst...YclllsPsLahlscshspclpcalcsGGsllhshhSGhhsEssplhhuthPGs....LcclhGlpl.cEh-sLssp.....pp.plp.htGp.......hpsphap-hl...pspsAcs..lApaps..t......Gp.PA....lscpthGc..GpshYlus.....t.spphlppllpplhsc.tslt	....................................................clAl.....laDa-s.....hWuhc...t..........sp...ts.hp............Y.pp.ltpaY.c.sh..hctslssD..ll....s....s...c.....s....-.....hss..............Yc..lll.sPsl..h...hlssshsp+lppaVcs.GG..pll.so.....hhoGhhs-pstl...h.hu......sh.P..Gs....L.....pclhGl.ps...p.-h...s.....sLhss............................ppspl..p....htGp......................................hp...s...p.ha...s.-h....l........ps..p..s......A.ps.....lApYts.......t.ht...........Gt..PA.....................lTpp.t.h....Gp..G.pshYlus..........t.st.t.hh.pthhtplhtphsl.t..............................................................................	0	123	237	290
+8365	PF08533	Glyco_hydro_42C		Beta-galactosidase C-terminal domain	Bateman A	anon	Pfam-B_2131 (release 5.4)	Domain	This domain is found at the C-terminus of beta-galactosidase enzymes that belong to the glycosyl hydrolase 42 family [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.71	0.72	-4.46	26	633	2012-10-02 20:10:03	2005-09-22 17:02:10	5	6	441	2	201	611	24	56.50	23	8.50	CHANGED	Glclpp..h..ttpspahFhhNaoscstplsl....stttppllssph.t.....hslpPhsltVlct	................tVpspt..R..pssps..palFlhNaos.cs.....tp.lsl....stshp-llsu.p...h.hpst............lsLsshsVtllp.................	0	72	140	172
+8367	PF08535	KorB		KorB domain	Bateman A	anon	Pfam-B_20369 (release 10.0)	Domain	This family consists of several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon [1]. This domain includes the DNA-binding HTH motif [2].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.72	0.72	-3.83	17	2280	2012-10-04 14:01:12	2005-09-23 14:10:54	5	9	1911	4	384	1460	462	83.50	29	28.74	CHANGED	stGhppu-IA+pLGKstuaVopahuLh-hPsslcphhssthssslcsl.-LtpshccpPpcVpsal.....tstspplTRusl...pchlcsc+psp	..........shTQp-lAcclGKS..RsaIuNhLR...L.L...p.....L...Pp.p.l.pp.hl.p.pG.p..l..o.....t...h..t.....................................................................................ttttthhh...................................................................	0	127	237	310
+8368	PF08536	Whirly	Plant_TF; 	Whirly transcription factor	Mistry J, Pachon DMR	anon	manual	Domain	This family contains the plant whirly transcription factors.	20.00	20.00	22.40	22.10	19.70	18.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.63	0.71	-4.70	4	82	2009-01-15 18:05:59	2005-09-28 13:43:07	6	2	35	12	47	76	4	129.40	45	44.76	CHANGED	ulYKsKuALplcsVtPoFsulsSGshhlcRsGulLLphAsAsusRpYDWppKtsFhLSsTEsupLss.MuupsSCpFFHDPu.tsuustGpVpKuhKVEPhPDGS.GhFlNLoVssu..psscpF.sVPVohuE.Asl+phhs	...................lYKGKAALolpPh.PpFstL-SGuh+ls+cGhlhLpFAP.......A.......l....G.............tRp..YDWs+KQh.FuLSsoElGoLlo...LGsp.-S.sEFFHDP..htpSstGpV+KsLplcPh..sDus.GhFhsLoV.sph...p...s...s-ph...lPlTcuEFuVhhosh.........................................	0	10	32	40
+8369	PF08537	NBP1		Fungal Nap binding protein NBP1	Mistry J, Wood V	anon	manual	Family	NBP1 is a nuclear protein which has been shown in Saccharomyces cerevisiae to be essential for the G2/M transition of the cell cycle.	21.50	21.50	21.60	21.60	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.20	0.70	-5.23	6	52	2009-01-15 18:05:59	2005-09-28 14:11:52	5	2	26	0	25	47	0	225.70	33	97.19	CHANGED	Mh-slKshhssa.hh......csDGRK+EaGsLs-h+cRp..+sR+tpsppcucshh+hs+...............................sssptot.phtsphpt..................ssspcupt+shhssI+ulFSs-ppslptMppA...lshhL.s.otsppspcc...hpsRIlRS-sFKKKlhEhcYscphLppLR+Gupstp.sh.t.su.p......DpVlLLQ++lcch-c+ltplppELp.spKcLpFupEKspLLpsLLDDANIDscYlKSRRsIpNL.p.p-slpPp.csLs..PSPhR..sVNPLFTSSPlRpssppupcssspshp..........-NFYsKYP+lPcTEpLspptt..............ccSLSPlRlDYS+YSS	..............................................ts.sh.++pht.l...+ppp..p.t......pspphhph.+...............................c.t..pt......................................................................................................................................................................................................................Dp..L......phpt+httlcppLp........hpctLpaspEK.clLpslLDsuNID...pYhcSRRshpNl.p.p-p.....lKPh....sLs..P.SPhR.........tsNsLhTSSPh+h.shpsp....pshp...........sh..sthPp.P.pph.ppp................cco.........................................	0	3	10	17
+8370	PF08538	DUF1749		Protein of unknown function (DUF1749)	Mistry J, Wood V	anon	manual	Family	This is a plant and fungal family of unknown function.  This family contains many hypothetical proteins.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.96	0.70	-5.53	8	206	2012-10-03 11:45:05	2005-09-28 14:46:02	5	5	158	2	158	362	33	286.70	31	88.64	CHANGED	Muhphss......GlLHpYsp+L.......lAFEasosush..+sps....LlFlGGLGDGLhTVPYlpsLAsAL.......-tuuWSllplplSSSYuGWGTGSLcRDsEElppsV-Yl+sph....uG...sppKlVlMGHSTGSQDVlaYLopu.......................tspV-GuIlQAPVSDREAhhpshtc...........cthcchVshA+ch..lccGpuc-llPpEascthhh...soPlSAhRahSLsusc.....GDDDaFSSDLoDE.......cLscoFGplpc........PLLlLhSppDEaVPsal..DKpsLLsRW+pusc....cphWspp.SGIIsGAoHsVs....scupsts.chLlccVhuFL+	....................................................................................................t..............shla..a...t....t........ssaEat..sss...........t.p.s........llFlGGLs.DGhhos.sYhts....LupuL.................ptt..sWSlhplhL...oS...SapGa.......G....h.u....S...L..c...p.D.......s.c....El.sph.lp..Yl+sh........................s.p+lVLhGHSTGsQDllcYLp.pss......t........................p.sl.-.G...sI.LQAP..V.S.D.REuhthhhpt....................t.hpphlphAcph.....ls........p...u...p.s...pp..l.h.Phphsshhh...........................ssP.loAhRahSLsu.t........u-DDhFSSDL..s-..-.........pLpp.saGhlsp...................slLlLhS..spD-aV.Pthl..Dpp..t.L.lp+appsst..............t.hs......otll.s.....AsHslt....t..t......hhthl.tah.t........................................................................................................................	0	50	92	139
+8371	PF08539	HbrB		HbrB-like	Mistry J, Wood V	anon	manual	Domain	HbrB is involved hyphal growth and polarity [1].	22.00	22.00	22.10	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.39	28	284	2009-01-15 18:05:59	2005-09-28 16:01:24	6	8	167	0	164	267	1	140.30	32	25.68	CHANGED	pphosssAWshlpstllslF.........cucslp.hs..lEDLNclVphalppplppp.hss.....hlh...t-lcpLLssGhssLccpl.....pts.....s-+LlspLsElW.hFFsslLPhlQAlFLPlp.......htt.t.....tpstp.h...............................upELslRpLsLluFRDhllLshhpshthh	............................................................h..hsssssWs.lpstVlslF.........psc.sl...t...l..............sLNchl.c..h.hlppplssh.hsp...................hh........ppLLspGhhhLcc.pl..........................chh.................ps..pp.hl...sp...Ls-hWpaFFsplLPhlQAlFhPlp...............................................................................................................upp.slRplsLlsFRDhllLshh.t....t.....................................	0	36	68	110
+8372	PF08540	HMG_CoA_synt_C		Hydroxymethylglutaryl-coenzyme A synthase C terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	25.10	25.10	25.20	25.30	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.87	0.70	-4.93	10	2505	2012-10-02 12:25:54	2005-09-29 09:26:20	5	15	1386	46	503	1607	169	142.60	23	53.54	CHANGED	IVFDpulRuoHMpHAYDFYKP..DLsSEYPVVDGKLSlpCYLpALDpCYppYssK..hpphhtp..t.spthsLccFDahlFHoPaCKLVQKShARLlaNDFlppssp.phsslhccLpsh..tslch--oYpDR-lEKshhploKshaccKspPSLllsspsGNMYTuSLYuuLASLL.ptuss-LsG.KRluhFSYGSGLAAohFSh+lssDsssho..p..IsslhDlps+L.DsR+phoPE-FsEshclREpsHtpKsFsPpuS..l-sLhPGTaYLsplDchaRRsYup+	...............................................................hh........................................................................................................................................................................................................................................................................................................................................................................s....hsp..GNhYsuolahshhS.hl.........t........t......................s..pp.............lhhhSYGSG..uphat.h...l....t...................................................................................h..tth..............a................................................................................................................................................................................................................	1	143	271	402
+8373	PF08541	ACP_syn_III_C	ACP_C; 	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal  	Mistry J	anon	Pfam-B_67 (release 18.0)	Domain	This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.41, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.64	0.72	-3.97	187	7398	2012-10-02 12:25:54	2005-09-29 09:55:06	5	25	4322	91	2044	8046	1911	89.30	33	25.98	CHANGED	Lpps.slshsDlDhhlsHQANhRIlcs.hsc+Lsls..-..+shhsl.pcaGNTSAASlPlALscslcpG..clcsG-hlllsu.FGuGloWGusll+h	.........................................hppssls.h.p-..l....D..ah.l.s.H....Q............AN....h....R....I...l....c....s.....h.....s.....+.....+......L...........s.......l.......s........-.........+.s.....h...h...s.....l...p....caGN...TS...AAS...lP....lu....L...s.c....s....h....c....p.G........c.l..+..p.......G........c.......h........l.........l.lh...u..F.G.uG..hoaGusllc.......................................	1	605	1328	1740
+8374	PF08542	Rep_fac_C		Replication factor C C-terminal domain	Mistry J, Wood V, Finn RD, Coggill PC	anon	Pfam-B_930 (release 18.0)	Domain	This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA).  The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A [1].	21.00	21.00	21.00	21.00	20.90	20.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.59	0.72	-4.00	117	1565	2010-07-14 04:08:27	2005-09-29 17:21:44	6	38	497	21	1053	1492	176	89.50	21	25.10	CHANGED	shs..thlc.pllpphhp.p.....shtc..................spphlt.cLhsp...GhuspsIlpplhchlhph....sh..sph+hpllptluph-hRltpGssphlQLpuhlAph	................................................................................thlc.phlpthhs.t...............shpp...............................................s.tptlp.c.Lhsp...GhuspsIlp...p..lhchlhph............phs..sph+hcllctl.uph-hRlspGssphlQLtuhlup..................	0	361	595	866
+8375	PF08543	Phos_pyr_kin		Phosphomethylpyrimidine kinase	Mistry J, Wood V	anon	Pfam-B_787 (release 18.0)	Family	This enzyme EC:2.7.4.7 is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.55	0.70	-5.18	132	8058	2012-10-03 06:25:16	2005-09-30 10:04:10	7	34	4351	38	1754	12925	3225	233.80	27	80.50	CHANGED	DouGGAGIQADLKThpuhGsaGhosITulTAQN..TtGVpulpslss-.hlpsQl-ulhsDlslsAlKhGMLusscllcsV..Actl.cp.hsh.slVlDPVMlupoGspLlps-u.lpsl+cp..Ll.PhAsllTPNlsEAp.....hLsG....hplp...s.p..-hcpuAcplhp.h...GspsVLl..KGG.H.h..t............ppsh..DlLh....sssph.hthpstRlsTppTHGTGCThSuAIAAtLA+Ghsl.cAVppAKpalptAlp....pshplG..pG.tGPls	.............................................................................................................................Ds.uGuGh.ADltshtths..........sauhsslTsl.s.s.s.....s....t....s.....t..h........h.......p....h..l.tt..Qh...p...s..l...h...p.......s...h..........t........h.............c...A..l...K...h..G..h....L.u..s....s....c....h....l........c...h..l.....s....c.....h.....l......p...........p................p..........h...............l...V...l..D......P.......V.....M......s..s....p......s...........u...s........t.....l.....l..s....s.s.s....h...p....s...h....p.....p.....p.......L...l......P.h...A......s.....ll.TPNls.E.Ap...................hLsG.........hplp.........................s..c...........-h.h...p..A....u.......c....t..Lhs.....h..............G.s..p.....t....V..l..l....K..GG..c..h...t............................................pps.............-.hlh..............s.s.......p...p....h...........h......h..h..p..s.....s.....+......l......s...t.......p......p....s...+..G.TG.s.o.h.uu.....s.ls.u..........t..........L...s..........p.......G.....t...........s......l..t.....c....A.......l.p..p.A..p..t.a.ltpulp.......psh.p..h..s..............................................................................................	0	531	1053	1453
+8376	PF08544	GHMP_kinases_C		GHMP kinases C terminal 	Finn RD	anon	Prosite	Family	This family includes homoserine kinases, galactokinases and mevalonate kinases.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.76	0.72	-3.78	121	12811	2009-09-10 21:23:33	2005-09-30 10:45:27	8	48	4606	85	3000	8683	2225	82.10	18	24.10	CHANGED	hhpsl......t.............tpht.htphht..t...............hhthhhsplpplhcth.pphG......hssthoGu..Gsslhslh.............ppppsppltptl.ppthtp	..............................................................................h....h.t.............tphphh.up.hhp.ts..t......................h.hthth..splc.plhphs..tphG........shuuphoGu...GsslhuLs.................sp..pp.spplhptl.tt....t.......................................................	0	971	1843	2506
+8377	PF08545	ACP_syn_III		3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	Mistry J	anon	Pfam-B_135 (release 18.0)	Domain	This domain is found on 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III EC:2.3.1.180, the enzyme responsible for initiating the chain of reactions of the fatty acid synthase in plants and bacteria.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.70	0.72	-4.32	170	6937	2012-10-02 12:25:54	2005-09-30 14:13:13	5	20	4279	91	1726	8497	1908	78.70	35	23.31	CHANGED	FDlsA.u...CoGFlauLshAsshlpuG.th+plLVlGu-thS+.hlDa...s...D..RsTsl....LFGD..GAGAsllpss......ppt.......u..lls...splto..DG	...................FDls.A.ACuGFlauLs.s.As.p.h...l...p.........o......G....t...........h..........+....p...s..LV.lG..u.-..p.h...S+....hl...Dh.......s.........................D.......Rs.Ts.l.....................L..F..GD...GAGAsllpss.......pp...............s...lls.hphts-G....................................................................	0	550	1116	1470
+8378	PF08546	ApbA_C		Ketopantoate reductase PanE/ApbA C terminal	Mistry J	anon	Pfam-B_396 (release 18.0)	Family	This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169.  The reaction catalysed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH.  AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway [2].  ApbA and PanE are allelic [2].  ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway [1].	20.90	20.90	21.20	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.36	0.71	-4.13	112	4691	2009-01-15 18:05:59	2005-09-30 16:41:07	6	30	2834	28	1372	3635	1120	124.90	25	38.00	CHANGED	slttthWpKllhNs.....shNsloulhs...sss.uplh....tssthpplhptlhpEshtlu.........pupG...........................ht.hstp........................hhctlhphhpt..........sss.....p..psSMhpD.lppG+..oEl-hl.sGtllc.h.....ucphGls...sPhsphlhp.ll.+t.hp	.................................................slttthWpKlhhNs.................shNsloulhp...................ssh.uplh......................pp.s.t..h..pph...h.pplhpEsh.sVu...................pt.p.G.........................................................hp...hstp.........................................lhpt.lh.p.lhpt.............................sst........p.....hoSMhpD.lp.ptR....oElDhI.sGhllc.h.........uc..p.t..G...ls......s.Ph.sphlhphl+th........................................................................	0	379	802	1142
+8379	PF08547	CIA30		Complex I intermediate-associated protein 30 (CIA30)	Mistry J, Wood V	anon	manual	Family	This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits.\	 This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation [1][2].	19.70	19.00	19.80	19.00	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.90	0.71	-4.37	83	768	2012-10-03 19:46:52	2005-12-01 09:21:38	7	21	485	0	464	811	928	156.70	22	55.05	CHANGED	hcFsss......s...........shpp...WtslsDsVMG.GhSpuphph....................s.....ttuhFpGplShc..........ssGGFuShRo.........hps.hDlu..sasulpL+l+...GDG.+pYphplpsp..st............hsshsYptsFt.....T..sst...........Wpslc................lPascFhss.hRG+hlpst...s..h...sssplpplulhlu...........sc..psGsFpLpl	................................................................th.pp....WtshsDt.s.h.G...Gh.Spup.hphs...........................................s..stuhFpGplshc.............................................................ppu.Gasuh.Rs......................................hp..hc.h.s.sass..ltLcl+..............G..DG.......+..p...Yhlplpsp..s..............ts.ha.ptth.....st..sst....................Wpplp....................................................................lPaspFh..s...c..G.p........h.h...t............h...........p..plppluhhht..............st....G.atL.......................................................	1	145	272	386
+8380	PF08548	Peptidase_M10_C		Peptidase M10 serralysin C terminal	Mistry J, Rawlings ND	anon	Rawlings ND	Domain	Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs).\	\	\	\	The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain Pfam:PF00353.	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null --hand HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.11	0.71	-4.68	15	432	2009-01-15 18:05:59	2005-12-01 09:50:32	6	100	256	24	107	457	56	201.30	36	37.88	CHANGED	ANhoTRTGDTVYGFNSNT-RDFYoATSuSsKLIFSVWDAGGNDThDFSGaoQNQRINLNEuSFSDVGGLKGNVSIA+GVTIENAIGGSGNDlLIGNsAsNlLKGGAGNDIlYGGGGADpLWGGAGsDhFVYuuuuDSssuAsDhIpDFpSG.DKIDLSuhspsss....L+FV.DsFoGcAGEAlLoYDuuoslosLtlshuGcss.sDFlVplVGQsss.oDhIV	....................................................................................................................................................................................s.pTRssDTsY........GFN..S..s.....o...s...c......D....a.h....o..........u......s......s....s........s....s....p..l....l....F.olWD.uGGsD..ThD..FSGa.s.p...sptIsLs.......t...s...s..........a..........S.....s..........l...G..............G...............h...........t..........u.....N..........lo..........IAhs.sslE.NAlGGsGsDhlhGNtssN.l.Gss.........................................................................................................................................................................................................................................................................st..hhsststshhhhtt.tts.sts.Dhlh.DF..p...u...D.+l..sl..t....h...............h...hh....t.t...............h...t.........t........t...........................h.h............................................................................................................................................................................................................................................................................................................................................................................................................................	0	13	50	73
+8381	PF08549	SWI-SNF_Ssr4	DUF1750; SWI-SNF_ssr4; 	Fungal domain of unknown function (DUF1750)	Mistry J, Wood V	anon	manual	Domain	This is a fungal domain of unknown function.	19.50	19.50	19.50	19.50	19.00	19.20	hmmbuild  -o /dev/null HMM SEED	669	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.45	0.70	-6.22	3	99	2009-09-10 22:09:48	2005-12-01 10:49:12	5	3	82	0	83	100	0	503.50	32	94.93	CHANGED	MD.DPASRVPuQLLPHMHLVSRaRYPLMHMMPTDTVV-YLLSAPKIVREApPMHWTFLDGPQDGTVMLTWQPLNHLGTNFASDGYVWADVEQAFTFEA.RGYVVEMWLHRSGYHPPNESVAIHCRRRYRLLPoKVPNPSLPPPDPSLWIVHYSRAPPsDHIPANRIPVSPQVQsMLAQRRFLQsQGQLARKDFMLHDRNNWPTIsLPPQhA.sQuhtQPsGPYPNAMVGRQPFYPQPGssAsPPsusussKAPRGHRASoAAssAAosDFALEDE.DVSsGDLMDLLTPREVSKMRYQQHHEWMEEILASPYAISQITPVSLGLGRKGELESLTAGFFDAPVGPusGDSc-GsEusQATKLEPE+A-EFADRVAKKVADMTAEIEKLKKRHARRMEKFNRTStLKDAEpRLRDAAAsPtDTGSEIWRLEGRlEhsTE-DsucluPlEHKAKYKVDDIVREVEsSWpKpIVPEP+VSCVEKGGLLEKI...EPEPso.......................hhuDlDIDMGHTDSHLLDQF.TAtGssuQotuTsAP.....uAsGQAsPTATGVAssQPsA....GLDI-MDhGDupsouTAuGETGDWVMVN-s................KKDDslshPstph.tspTPGSGLQGLTPG.souuDsGLDusNFDFTN...MDSAGDALAAY.........TEQN-GLDLP.DLENSAFGDAFH..........ASDNEsTHHHDADDMS	.......................................................................................pas......h.hppshcaLhtAPpls+-.tPhhWta.lDt.P..DGolh.LsWQs..phGspFuoDGhhWsssE.hap.ph.pGh.....................lEhaht+sGahs....s.EphAhHsR+RaRLh..ss...s...s.......sDPsLa..llHYu.u...-plPssh.l.hs.th.....pth....httRp...h.L.ptGQ.lhRK-FMLpDRs....sWPpls...t....p........s......t...h..p.........h....s................................s.t............t......t..t.tps........s........h...............s..........-..h.s..........h.--E.-sSpG..DhhDhlTPR-lSh.RYpppHEWMEElhuSPYtltQI.PssLGLGh+GE.LtsLTtGhF.s....s....t..t....t.s......h.s.+hcst.sc-FtppstcphtthpsEhpphctpHtcthtphpp.shhhptEhtLR.hh......t.Gs-h.a+hE...s+hp....tpt.t..................p............l--lltplpttht+thss....tltplpcGGh.p.....t..P..........................................................s....DhsM..tst....t.hsth............t.......s.s...........................................s...................................................t.D.h...h...t...........s....p.................t..t....................s.....t....t......s......s-h.l....hlsp.t.............................................s.........s............................s.t..........s...h.st...................s..h..........-....hts......hsoAG-ALAsY...................tt.s.thsh..th.-sSAFG-AFH..........usptt............t..................................................	0	20	43	67
+8382	PF08550	DUF1752		Fungal protein of unknown function (DUF1752)	Mistry J, Wood V	anon	manual	Domain	This is a family of fungal proteins of unknown function. This short section domain is bounded by two highly conserved tryptophans. The family contains Swiss:P34072 that is thought to be a negative regulator of RAS-cAMP pathway in S.cerevisiae. the Sch.pombe member is a GAF1 transcription factor Swiss:Q10280 that is also associated with the zinc finger family GATA Pfam:PF00320.	20.90	20.90	20.90	20.90	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.69	0.72	-7.15	0.72	-4.36	48	460	2009-01-15 18:05:59	2005-12-01 11:05:33	5	14	156	0	340	467	0	29.00	39	4.13	CHANGED	lW+has+s+p.....plss..scRlENloWRhhstp	............W+hhspp+s.....plss..upRLENloWRhWsp......	0	88	185	291
+8383	PF08551	DUF1751		Eukaryotic integral membrane protein (DUF1751)	Mistry J, Wood V	anon	Pfam-B_13217 (release 18.0)	Domain	This domain is found in eukaryotic integral membrane proteins. Swiss:Q12239, a Saccharomyces cerervisiae protein, has been shown to localise COP II vesicles [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.38	0.72	-3.67	23	355	2012-10-01 23:21:32	2005-12-01 11:26:52	5	5	269	0	250	1107	281	98.30	29	27.91	CHANGED	Puhsh.....aPWoLlTusalEtslashllshlsLhluG+alEphWG.upEhlKFllllsshsNLlshlhtllhhhhops.p..L..h.lsGthulhsGhlVAhKQ	....................Pshhh.....as..W.ol..lTsshl..E.....p..s.....l..h.slllshhslhhsG+hLE.hWG..up..............Ehh+.Fl..h..llshh.ss.lls..hh...hh..l..lh..ah..h.......ots.p..........h....Lh..h.lpGh.huhhsGhLVAh+Q..................................................	1	73	135	210
+8384	PF08552	Kei1	DUF1753;	Inositolphosphorylceramide synthase subunit Kei1	Mistry J, Wood V	anon	manual	Family	Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase [2]. It is localised to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2 [2].  Kei1 is essential for both the activity and the Golgi localization of IPC synthase [2].	25.00	25.00	34.10	33.90	23.10	21.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.16	0.71	-4.63	17	133	2009-01-15 18:05:59	2005-12-01 11:35:41	6	5	128	0	100	134	0	176.00	31	63.88	CHANGED	poFLuhhsLhhGsEllhhhhlhNKsoGlYGlLulhTGasLshhQhhhYlaSlhsLshahhsl.pl+..c...........................psshpshhlshlYshDollsshaThhFshsWFht..........pstsssst............................sstsusstttsspsssu...htp..................................utstthEhhholhlslhhhllRhYFshllhuas...pplL+p.hhts	.....................pFhhhhsL.hGspllhhhhlhNKhoGlYGlLAlhT..Ga.Ls..hhQlshYlaSlhsLslhshhh.pI+...c.............................psshpsltlAalYhlDollsshaThhF.ussWFhh................tss......ssss.t..ts.....................................ss..tss.tssttstpstst..htp..................................ssshp.EphholhllsshhllRlYFshllhuFA...pplL+p.h...h...........	0	25	54	84
+8385	PF08553	VID27		VID27 cytoplasmic protein	Mistry J, Wood V	anon	manual	Family	This is a family of fungal and plant proteins and contains many hypothetical proteins.  VID27 is a cytoplasmic protein that plays a potential role in vacuolar protein degradation.	27.20	27.20	28.90	30.90	23.90	26.00	hmmbuild  -o /dev/null HMM SEED	794	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.72	0.70	-13.23	0.70	-6.31	9	256	2009-09-11 00:42:47	2005-12-01 11:45:52	5	5	188	0	187	259	0	563.90	30	87.52	CHANGED	M.hL+p....hhGsu.sppEllpIPuGpLYLlR..pSPKGspECIYpDAssoIR+Tu.-apYQLVVp+saEEGEsph.......tt.-s-Dsshs.........-DEhsFhlDcsLch+hphpctGctslsWcDlpGDpG.DhaEFVssss.lshspl-pFthTshcC.YEpKY++SspcAo-.--Lppacaps.hs............cscphsh--ph.ssshtphsss.scssps.s.htcutpp...t..............................ph.t..hhsttpu-LalYDshotpFlLQ..cssVslslh-sGc.acaWLtlcGt-p..Luhslss-hNPsFshpphSFlFNahssc.....shSWhL+FcDhsshscFppsaspslWEphNcpKWscs.csEpcYl.-Aaps.........hph-Dt.....ps..pE-E-E---E--spu.....ucpth-s-pa--ccsttt.pp...sssNppLAVGa+pDRSaVlRGsKIGVF+pss.sspLEFsTsIpplus.pGKhFsPcKhMLHtpD+phlLpDss.stspLY+MDLEhGKVV-EWcVpDcs...VssauPssKFAQMTsEQThlGlSpNulF+IDPRlSG.sKLV.-uphKpY.ASKNsFSuluTT-pGYlAVuSsKGDIRLFDRLGhNAKTtlPALG-PIlGlDVSADGRWlLATC+oYLLLlDshIK-G.KNtGpLGFp+SFst-uKPpP+RLplpPEHsAah.p.T.tcPlsFT.ApFNTGhsppEpoIVTSTGPYlloWShKclLpGc...psPYhIKRYsssVhADsF+FGoD+NVIVALccDVsMsp++shppPoRpslsss...........................shhNp.h	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.a....................sahl+F...s.........pF.tth.thha.t..t..ph.tp...p.p.Y.hhp.ht............................................................ht.pt..................pptttt..............p.tt.ttt.....................tpt.....p.p.p.......p........pp...t.........t............tthsp...p.LslGh..DpSallp..ss.t......ItV.a+p..........ps......t......l..p.....at........s.shs.plp.....s........pG...p.......h...s..PpKsh.....L.hp.t-pshlL.....s.t.....p......ss.....t.....l.....aphDlEhGKlVpEWch.p...c...c...hs...hhshssp.s...KhuQhs.s.p.p.TFlGlspNsla+hD.....sR.........l.....s.u......sp.....l...........l...t.s.........p....h............+.........p...Y...spps......s......Fs.sh.ATTtpGhlsVuSpcGcIRLa...............s.......+..............h...............u.....h..p......AKTtlP.u.LG.pPIhtlDVotDG+WlLuTscoYLlLlss.h...p.cs..csps.ph..GFp.pph.sts.ppstP+hLtLpPtcst.h...t...tps..l..pFs.ApF..s..T..t.....s...p....pE.ppIlsusG.ahlhWshcplhpup.....ptsYph.......................................................................................................................................................................................................	0	69	126	168
+8387	PF08555	DUF1754		Eukaryotic family of unknown function (DUF1754)	Daub J, Mistry J, Wood V	anon	Pfam-B_10536 (release 18.0)	Family	This is a eukaryotic protein family of unknown function.	21.70	21.70	21.70	21.90	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.32	0.72	-10.62	0.72	-3.40	37	249	2009-01-15 18:05:59	2005-12-02 16:25:23	5	7	201	0	171	240	1	86.70	28	58.97	CHANGED	c....Ysp.sssGpLKLKGst..h............+KKKKKccppspp....pctstpspppppppstcst.....................................tptt.pttsthshTcAE+pacchpcKRhpc	.......tYps.ss..tGpLKLKGss..h..............hh+KKKKK..c+ccpc.p......tpt.htssp.p.pp.ppp.pttt....................................................................thT.AEt...tacchpcKR........................................	0	56	89	131
+8389	PF08557	Lipid_DES		Sphingolipid Delta4-desaturase (DES)	Daub J, Mistry J, Wood V	anon	Pfam-B_9504 (release 18.0)	Domain	Sphingolipids are important membrane signalling molecules involved in many different cellular functions in eukaryotes. Sphingolipid delta 4-desaturase catalyses the formation of (E)-sphing-4-enine [1].  Some proteins in this family have bifunctional delta 4-desaturase/C-4-hydroxylase activity.  Delta 4-desaturated sphingolipids may play a role in early signalling required for entry into meiotic and spermatid differentiation pathways during Drosophila spermatogenesis [1].  This small domain associates with FA_desaturase Pfam:PF00487 and appears to be specific to sphingolipid delta 4-desaturase.	20.30	20.30	20.30	21.60	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.02	0.72	-4.71	24	352	2009-01-15 18:05:59	2005-12-05 16:10:50	5	5	268	0	247	355	8	37.80	47	11.04	CHANGED	sspsDFhWoho--PHssRR+tILpKa.PElKcLhGs-Pth	........csDF.WsYT-EP...HssRR+tILpKa.PEIKcLhGs-Ph......	0	89	133	203
+8390	PF08558	TRF		Telomere repeat binding factor (TRF)	Daub J, Wood V	anon	Pfam-B_8956 (release 18.0) 	Domain	Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain Pfam:PF00249 at the carboxy terminus [1]. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection [1]. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres [2]. This domain is composed of multiple alpha helices [3] arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors [4].	25.00	25.00	27.10	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.23	0.70	-11.43	0.70	-5.03	27	262	2009-01-15 18:05:59	2005-12-05 16:13:17	5	4	151	11	139	253	0	216.50	25	37.59	CHANGED	hhp..oL.shLDsl......................usQlLphltp....s...h...htp.ts....spspsFppltslFchhpcha.scsshl.s.pl..............hpsppthl.psl++sNhuphlssshss.c.luh...h.LsptFl-lFsspss......................................phh+spshLhlpLKTQAaIsulc..............tt.cppp-lLcclhssshps.h..hp.........l....sEhphh.+hcpR+cpLh....ppsshpsL.ppasatsFh+clhsalppphs.....hllhutptts.spt.ps	.......................s.......hL-.h......................shpllphhtp....................................spspsFpph.pslhctlhphh.......spss.........................hpt+phhlhph..Lp+ls.uph.L...sspF..sspp..ls....hEss.thhchhpsEts.................................................hh.csppplhh.lKpQAhlsshc.............................................ptphcptp-lLc.clFscs.sp......................................pph+ppLl..lp.pcsshcslhppas..apphhcclhsalppphs.....hLhhttpthhpp...stp.................................................	0	15	46	92
+8391	PF08559	Cut8_C	Cut8;	Cut8 six-helix bundle	Daub J, Wood V, Eberhardt R	anon	Wood V	Family	In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome [1]. Cut8 comprises three functional domains. An N-terminal lysine-rich segment (Pfam:PF14482) which binds to the proteasome when ubiquitinated, a central dimerisation domain (Pfam:PF14483) and a C-terminal six-helix bundle (this entry), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding [2]. Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8 [1]. Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome [1]. In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 [1]. Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum [1].	21.00	21.00	21.50	21.50	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.92	0.71	-4.36	19	160	2009-01-15 18:05:59	2005-12-05 16:15:06	5	5	156	3	123	156	0	140.60	30	43.46	CHANGED	PolpsslplLpphhpplhsslP..YspsspS......DYAYhRl+tpLhphLssLsDas.paLPP.....pcsphptSLpFLDtATpll+pLPsa-otpaNhhKspsY-plupsWhlllpcuucctsshth..s.....................pcLpc+NppSss+.hppsl	...............................PolpsslphLpphppplhpulP..hu.psspu..................DYAYsRl+.pLsphlc.sLsDas...phLPP.....pp..p.phssSLpaLct.A.Tcl.l+pLPpW-stpaNhh+cpsa-plupsW.hhlIcc.uucc.tuthphp.sth...................................ppLtcaNppusGc.hpps......................................................	0	30	60	103
+8392	PF08560	DUF1757		Protein of unknown function (DUF1757)	Bateman A	anon	Bateman A	Family	This family of proteins are about 150 amino acids in length and have no known function.	21.00	21.00	21.80	21.50	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.94	0.71	-4.53	4	53	2009-01-15 18:05:59	2005-12-13 12:59:48	5	4	28	0	49	49	0	149.10	24	75.66	CHANGED	pWF+NhhGhp...lo-pEhtsIPpPcsEhslHlTh+ohQAhuLlGullsuPlsphlpu.+.Nhpthpssusphu+hG........hlhGlVsuPhLsYhch+stshsp.uLaDRCYRLRhNpsplRhDRhuhlushsG..........hhpsuhhGhVsGssluhsYs.l.Sshhs	.............................................................lPpPthphslHssh+uhpsuull...............Gu.ll.sPl..hhh.hpp..pp....s..p.thh..s........shspsupsG........slsGhshGPh..lohhch+s..hschchhDRsYRLRhNpspLphDRhslhuuslG....................hh.ss.hGhVsGlsluhhhs........h.h.....................................	1	23	30	49
+8393	PF08561	Ribosomal_L37		Mitochondrial ribosomal protein L37	Bateman A	anon	Bateman A	Family	This family includes yeast MRPL37 a mitochondrial ribosomal protein [1].	19.60	19.60	22.90	20.20	17.50	17.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.76	0.72	-4.41	23	304	2009-01-15 18:05:59	2005-12-13 13:51:40	5	2	258	0	232	295	1	89.50	29	61.01	CHANGED	spsssSus.suThlsslNlhKs.GpDPshL.DSEYP-WLWpl.LDssspstcttcss.............................................................................p.t++hhRptp+ppI+psNhLsph	....................................s....hsss.hsThltGlNhhKs.spDshhh.DsEYP-WL....Wpl...hss.t....thtcttcss...................................................................................htth+chhRttp+pp.I+psNhLpt..................................................................................	1	75	126	188
+8394	PF08562	Crisp		Crisp	Mistry J	anon	manual	Domain	This domain is found on Crisp proteins which contain Pfam:PF00188 and has been termed the Crisp domain. It is found in the mammalian reproductive tract and the venom of reptiles, and has been shown to regulate ryanodine receptor Ca2+ signalling [1]. It contains 10 conserved cysteines which are all involved in disulphide bonds and is structurally related to the ion channel inhibitor toxins BgK and ShK [1].	20.10	20.10	23.10	29.20	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.85	0.72	-3.69	26	238	2012-10-02 17:51:16	2006-01-03 16:31:09	5	2	114	25	72	235	0	54.30	49	22.83	CHANGED	CuDCPssC-NGLCTNsCpapDtaoNCsoLtpphuCpp.phlKspC.AoChCcscIh	CusCPssC.-.s...G.LCTNPCpapDtaoNCcsLtp...p...h...uCpc.....ph.....l.....+ppCtAoChCpscIh....	0	7	10	37
+8395	PF08563	P53_TAD		P53 transactivation motif	Finn RD	anon	Pfam-B_3515 (release 19.0)	Motif	The binding of the p53 transactivation domain by regulatory proteins regulates p53 transcription activation.  This motif is comprised of a single amphipathic alpha helix and contains a highly conserved sequence [1-2].	20.00	20.00	20.00	22.30	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.69	0.72	-7.08	0.72	-4.85	12	143	2009-01-15 18:05:59	2006-01-03 16:48:47	6	6	66	16	32	159	0	24.40	62	6.48	CHANGED	spptshs.PLSQ-TFp-LWphLsts	.....S-.ulEPPLSQETFSDLW+LLPEs....	0	3	4	6
+8396	PF08564	CDC37_C	Cdc37;	Cdc37 C terminal domain	Bateman A, Mistry J, Wood V	anon	Pfam-B_3345 (release 6.5)	Domain	Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the C terminal domain whose function is unclear.  It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain Pfam:PF08565 and the N terminal kinase binding domain of Cdc37 Pfam:PF03234 [2].	20.80	20.80	21.00	22.10	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.30	0.72	-4.16	31	299	2009-09-11 10:45:19	2006-01-04 11:51:26	5	10	236	1	188	289	3	91.80	29	21.44	CHANGED	h.h..Ps...............uhDP...........clF-.oLPs-hQcsh-occl-tlpcslucMss-EActhhcphs-uGlhs.puth.......sptphc-.ptp.....tthpptptppttsp	......................hPu...uhDP...........-lF-.oLPt-hQcsh-opsl-hlpcslucMss--Achhhc+hs-uGlhs.psth.................psppphp-.ttt.....................stts.............................	1	59	99	155
+8397	PF08565	CDC37_M	Cdc37;	Cdc37 Hsp90 binding domain	Bateman A, Mistry J, Wood V	anon	Pfam-B_3345 (release 6.5)	Domain	Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases.  This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37 [2].  It is found between the N terminal Cdc37 domain Pfam:PF03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 Pfam:PF08564 whose function is unclear.	25.00	25.00	26.30	25.10	22.80	24.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.05	0.71	-4.78	19	361	2009-01-15 18:05:59	2006-01-04 12:01:11	6	12	244	3	220	346	3	181.10	27	44.13	CHANGED	NKsptt........t.st.ts.pphpphsppsEpl...................................ccFuplp.scaccoppFLh-HspllsEpptctLlhpAFchphctccchhpplsHQullhQYlhp...Lu+..phss...+sslp.FFpKlts..sc..htptFpc-Vpshhp+l+sRupth....hcEpppps	.................................................................................................................................................pt.tt.........................tt..tp.ph.s.....................................................t..p...............p.ht........h.+....cFGhlp..cac-SpcFLp-H.s.p.L.l.s..E.c..s..ss.hLllhshchph....E.p..............Kp.s....hhcplsHQsllhQalh-....L.ucp.phss.......Rsslp.FFpK....lps...sct.hhcsFps-lpshhpR.l+tRAp.h.......hp-.t...t........................	0	65	105	170
+8398	PF08566	Pam17		Mitochondrial import protein Pam17	Mistry J, Wood V	anon	manual	Family	The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix.  The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase [1]. Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins [1].	20.50	20.50	21.30	47.60	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.97	0.71	-4.57	24	137	2012-10-02 17:14:55	2006-01-05 11:20:55	5	2	133	0	108	136	0	173.70	40	77.72	CHANGED	hsp........sshpssSssssssssss..............LsWssFFpLR+p...cRRhshsoSlhTulsusshuhsaLushplD.....sp.IhGlDPhhllGhushusuulGaLhGPhlGsslFpLhp....RpthtthphK-p-FhpRI++pRVDPSupShuNPVPDYYGEKIuSlpsYRQWLRDppAapRKsc.pF....l	............................thtstts.........putst..ssstttss.............LsWssFFpLR+p...+RRhslsuSlhsulhu...sssussh....Lu...sh..phD.......st.lhGhDPhhllGhushusuulGaLlGPh.lGsslapLhp....R.phhsthsh......K-+EFapRI++pRVD..P..S.upShuNP..VPDYYGEKIuSlpsYRQWL+DQ.+AasRKtppFl.................	0	34	62	93
+8399	PF08567	TFIIH_BTF_p62_N		TFIIH p62 subunit, N-terminal domain	Finn RD	anon	Pfam-B_31040 (release 19.0)	Domain	The N-terminal domain of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity.  The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal domain reveals that it adopts a pleckstrin homology (PH) fold [1,2].	21.10	21.10	21.20	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.35	0.72	-4.33	19	254	2009-01-15 18:05:59	2006-01-05 11:46:22	6	6	219	7	178	238	0	74.10	34	13.13	CHANGED	h.hpGtssaK.....Kss......GhLplspDpp.ltWhspussusp.sloltlspIssLQtoPtsusKlhL+llh+ss.......pshphhFss	.........h...stpspaK.....Kp-......GsLhlhs-+..lsWssc......upcpss....lohhhucIps..........phoPcu.psKl.Lpllh+ss.........sspsahF.....................	0	52	87	143
+8400	PF08568	Kinetochor_Ybp2	DUF1760; 	Uncharacterised protein family, YAP/Alf4/glomulin	Mistry J, Wood V, Lonsdale D	anon	manual	Family	This entry contains a number of protein families with apparently unrelated functions. These include the YAP binding proteins of yeasts. These are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS) [1,2]. The family includes Aberrant root formation protein 4 (Alf4) of Arabidopsis thaliana (Mouse-ear cress), which is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation [3] [14731255]. The family includes glomulin (FAP68), which is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12 [4,5].	21.40	21.40	21.60	22.10	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	633	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.13	0.70	-13.07	0.70	-6.28	29	316	2009-12-17 14:51:14	2006-01-05 11:55:57	5	8	213	0	210	288	0	458.30	17	85.82	CHANGED	M.............................................................htct.s......shhpt...spDhloalThl-hh..................p.p.thLstLhplL.p.-..pslsppIGWDLsphLl.hlstsp.................cChpplAchGNP+EllLpssEhLppLps....................................tDps..pp...................................ttp.t..hpl.ph.s...LlphlsshhpRIpTphPS+FLuhulpulhphhpp.s.....ppshs.hpFl.....+plhshpRsh.sst.sp.................ss-hsscs.s.hhssEssl.++lLpthhhphlpphlh..........shphshch.....sth...h.sttpppphhs.pp.ht.h..lhu+hstLu.....hDlsLps.h....h............ppl.....t.s.pspsh....s...-cs.hphc..h.h............cIslshpGsLlLhstthh.............pssp.........hsDhlhlhlchs........sshhpspulpDshhhhshhshpssp...........t.h....spthhhsalpsLhhhsspps...th+ttshplhsplLphtPpps.pachI+csLcsssat....slKsshluhLKc.lhpsppssptt.....................................................ptslhlsscphsslhsllhtshpthh..............hhp...p.hshlhuhLNlhhhlhp.........p.s..............hhhpchhcslcshlpthcschttp....................................stpph.ph....ssp.hLpps	......................................................................................................................................................................................................................................................................................t......t-...h...h.h.......................thh..l.phl.p..p.....hhtphGWsL.t.ll.h..h..pp...................thhp.lst..ssP+EhllthhEhltp.p........................................................................................................t..h.h........Lhp.lthhh.+l..t..shhstp.lt.hslpslhp.ht..s.......tt.t.........hh...............ptl.t..hps.....................................................................p...p....t...........t..-.....tp.l..hhh..lt..h....................................................................h.ht.h.th.......s..h...............................................p......t.....................th.....s.hhh.h.................................hh.hh.phh...........t........sh.......h..hhh...tp............................t................hh..thhphlhhhhhhp......s....th...Rph.sh..tlhphhlphhsp.ps.+aphhtph.lp.ss..h.....shps.hlthlKp.h..s.tts...........................................................hh.hss.th.tlh.hhh....pt..........................p...t...s.h....lhsh...LNh.hhhLh...................................p.p....................t.........th.pphhp.lp.hhp...tph...............................................................t..............................................................................................................	0	53	106	167
+8401	PF08569	Mo25		Mo25-like	Finn RD	anon	Pfam-B_5502 (release 18.0)	Family	Mo25-like proteins are involved in both polarised growth and cytokinesis.  In fission yeast Mo25 is localised alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner [1,2].	20.50	20.50	20.50	22.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.89	0.70	-5.41	23	518	2012-10-11 20:01:01	2006-01-05 12:11:16	6	8	288	6	335	448	8	289.20	41	92.36	CHANGED	MsFhF...p+.sp.KoPs-lV+slp-tlhtLt..............tscstcKs.-EluKpLsshKphlhGss-s-PssEp...lspLspEhhpp.-llh.LlpsLtpL-FE.uRKDlshlasplLRpphss...........ps.Ps......V-Ylspp.sclLshLlcuY-.......ss-luLssGshLREsl............................+a-sls+llLh...ss.......................pFap.....FFcalphssF-IuoDuasTh+-LLTpH+plVucaL...psNa-cFhs.phspLlpSsNYVT+RQSlKLLu-llL-RsNhplMspYlsss-NLKLhMpLLpDcS+NlQhEAFHlFKVFVANPsKspPlhcILl+N+-KLlcFLpsFpsD+h.cDcpFhDEKpall+pIppL.p	.................................................................................F...tp...p...+sPs-lV+th+-.l.h.L....................................................ts.pptpct.--luKpL.thKtlLhGs..................s..........-t...-.....P.s-t................lsQLspEhh.pp..slLhh..Llt..sL.hlsFE......u+K..DssplFspllRp..phss.......................c..ss.......l-Yl......sp..cll.hLhpGY-...............s.-....hALpsG.hLREsl...............................+a.-slA+.hlL....sp..............................................................pFhp.....FF.c.a.lp.....hssF-lAoDAF...sTF+................-LLT.+..........HK.........lsucaL...............ppNa-h.FFp...h...p.pLl.pS....p.N.YV..T+RQSlKLLGElLLDRpNhslMs+Ylsps-NLKlhMsLL+..D.cS+s.IQhEA..FHVFK.....VFVAN..P......pKs.s.lhpILlpNppKLlcFLtpF..........tt-+..........-D-QFt-E..Kthll+pIppL........................................	0	107	186	274
+8402	PF08570	DUF1761		Protein of unknown function (DUF1761)	Wood V, Finn RD, Bateman A	anon	Pfam-B_85869 (release 19.0)	Family	Family of conserved fungal and bacterial membrane proteins with unknown function.	26.00	26.00	26.30	26.80	25.20	25.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.71	0.71	-4.12	81	254	2009-01-15 18:05:59	2006-01-05 13:12:42	5	3	233	0	120	231	54	127.80	21	85.78	CHANGED	hlAlllAslsuallGslWYush..FGcsW...............hcstuhspcp..hcstts......shshshlsshlhuhhluhhhshhs.................................htohtsuhhhuhhlhls....hhsshhssshhapt+shplh..hIsuGatllsh................slhuhllsh	..........................................ulhluslhsahhuhhaassl..Fucsa...............hcutuhsspc......h+ptphh......shshshlsshltuhslutl.lsths.................................shohtsuhhhGhl....lhhu....h.ssthhsphha.....E..pRshp..hh..hlsuuapllth................lhlulhls.........	0	51	81	104
+8403	PF08571	Yos1		Yos1-like	Wood V, Finn RD	anon	Pfam-B_23321 (release 19.0)	Family	In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Yos1 appears to be conserved in eukaryotes[1].	19.30	19.30	20.60	20.00	18.60	17.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.59	0.72	-3.88	20	281	2009-01-15 18:05:59	2006-01-05 13:31:28	5	6	222	0	190	258	3	76.20	43	59.59	CHANGED	lhsLl.ulLLhlNAlAILsE-RFLu+lGW.usossps.u...............................sssolKspllsLIpuVRTlMRlPLIslNlllIlacLlLG	..................................................LhsLlpusLLhlNAlAlLsE............-............RFLs+.lGW..ut.sp.s.t.s..G..........................t..............ppsolKupllsLItulRTlhR..........l..........P.LIhlNhlhIlhtLlhG............................	0	51	99	153
+8404	PF08572	PRP3		pre-mRNA processing factor 3 (PRP3)	Mistry J, Wood V	anon	Pfam-B_7232 (release 18.0)	Domain	Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor.  The human PRP3 has been implicated in autosomal retinitis pigmentosa [2].	31.40	31.40	36.40	33.40	21.70	28.30	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.55	0.70	-4.97	21	355	2009-01-15 18:05:59	2006-01-05 13:48:31	5	10	293	0	250	343	1	212.70	39	38.51	CHANGED	ssPYhsspht..............tphpp+ppcshpFhctG+a.ppApchRpcsphE......chcpchtpt...scpsslpppp............tcph.ttphs.......................PslEWWDtshlsps..........shsslss-ts....t...........................p.ssIst....alpHPlslcsPh-...h.sss...slaLTKKEpKKlRRppRttppcE+p-+......I+LGLcPsP................PKVKlSNLM+VLss-A.lpDPTphEtcVRcphtERpppH.ccNppRKLTs	.................................................................................................................tsahDsphs..............htsttRpp+shpF.pppGKa.p.A.pph...RppsplE...................chptclspt...........s+c.s.Glppst...........................ths.hs.h.t.p.h..................................................................P.p.l.EWWDphllst.............................shpsl.sp..t..p..h...p............................................................................................p.psIT......hlpHPs.lpPP.t-.......hss...hshaLTpKEpKKlRRQp..Rttt.KEpQ-K.......IRLGL.PsP.............................PK.V+lSNLMRVLGs-A..VpDPTtlEs+V+pphAcRpptHpctNttRKLT.........................	0	87	141	208
+8405	PF08573	SAE2		DNA repair protein endonuclease SAE2/CtIP C-terminus	Mistry J, Wood V	anon	manual	Family	SAE2 is a protein involved in repairing meiotic and mitotic double-strand breaks in DNA.  It has been shown to negatively regulate DNA damage checkpoint signalling [1][2]. SAE2 is homologous to the CtIP proteins in mammals and an homologous protein in plants. Crucial sequence motifs that are highly conserved are the CxxC and the RHR motifs in this C-terminal part of the protein [3]. It is now known to be an endonuclease. In budding yeast, genetic evidence suggests that the SAE2 protein is essential for the processing of hairpin DNA intermediates and meiotic double-strand breaks by Mre11/Rad50 complexes. SAE2 binds DNA and exhibits endonuclease activity on single-stranded DNA independently of Mre11/Rad50 complexes, but hairpin DNA structures are cleaved cooperatively in the presence of Mre11/Rad50 or Mre11/Rad50/Xrs2.  Hairpin structures are not processed at the tip by SAE2 but rather at single-stranded DNA regions adjacent to the hairpin. The catalytic activities of SAE2 are important for its biological functions [6].	22.90	22.90	23.00	22.90	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.37	0.72	-3.28	22	209	2009-01-15 18:05:59	2006-01-05 14:38:56	5	9	190	0	153	218	1	83.20	35	12.52	CHANGED	sas-VlRp+c-Rcpl.pGs.p.sC..Csptapshut.t................................phh.lsphppcc+pchh.ptp........tp.hhpphu+HRapa.t+ssTPPGFWchDF.Ps	.............................................................EVVRcKp-RcpL..Gp...pC..Ctthatshs............................................t..tc.ccp..c..hh.................sphSRHRapa..h.ssTP.sFWcssF.Ps..............................	0	45	78	122
+8406	PF08574	DUF1762		Protein of unknown function (DUF1762)	Mistry J, Wood V	anon	manual	Family	This is a family of proteins of unknown function.\	\	\	    Swiss:Q07532 is known to interact with RNA polymerase II and deletion of this protein results in hypersensitivity to the K1 killer toxin [1].	21.30	21.30	21.50	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.88	0.72	-3.56	16	232	2009-01-15 18:05:59	2006-01-05 14:41:35	5	4	208	0	167	219	1	74.30	30	20.15	CHANGED	-sss-YVYDlYh.........hpps.--.pssp.s..........ppsIGalplh-csp-....hhp-----s....phhoDDEDSNsENaYpNDYP-DE	.........................................ps-YVYDlYh...........................tp....th.....................pslsh..l.hhhpp.....p.p..p...........hhs---..sc........h.pD--DSN.........sEs.apNDYP---..........	0	48	87	138
+8408	PF08576	DUF1764		Eukaryotic protein of unknown function (DUF1764)	Mistry J, Wood V	anon	manual	Family	This is a family of eukaryotic proteins of unknown function. This family contains many hypothetical proteins.	21.80	21.80	24.20	22.20	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-11.11	0.72	-3.24	19	96	2009-01-15 18:05:59	2006-01-05 15:47:32	5	1	85	0	71	96	3	111.90	24	68.96	CHANGED	pscK..............tstphslsshFsstptpppctp..t.........pspcspssp................ttp.p.phppsttRRcs.DGhhIaoh....EELp...hu..cu.GsTs..........pCPFDC-CCF	.......................................................................................................................ttp.............t.tp.ttpl-plFsshpppppptptttpt.....................p.pt.t.pp..................ppppptpspp.tttp.....s..ps..sp...sRR+TpDGhsIYot....-ELs...hu.....p.u.GsTs...............CPFDCpCCF.........	0	41	56	66
+8409	PF08577	PI31_Prot_C	PI31_Prot_Reg;	PI31 proteasome regulator 	Wood V, Finn RD	anon	Manual	Family	PI31 is a cellular regulator of proteasome formation and of proteasome-mediated antigen processing [1].	25.00	25.00	25.00	25.00	22.50	24.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.11	0.72	-3.33	26	230	2009-01-15 18:05:59	2006-01-05 15:52:27	6	3	199	0	156	220	0	74.20	35	24.24	CHANGED	shGcsDL.P.................sGhs..sshps.hss....................t........GGMh.sss...c.PhFss.tp...stt...s...........ssssPPGARa.DPhGP	....................................hGppDL.P..................Ghs.........sshpsh..hss..s.......................stt.........GGMhssPp...c.shFsp..h..........ssp.......G.s.........tth.ssusPPGARa.DP.hGP....	0	50	82	126
+8410	PF08578	DUF1765		Protein of unknown function (DUF1765)	Wood V, Finn RD	anon	Manual	Family	This region represents a conserved region found in hypothetical proteins from fungi, mycetozoa and entamoebidae.	25.00	25.00	25.00	32.40	22.80	24.50	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.56	0.71	-4.07	31	180	2009-09-10 15:38:14	2006-01-05 15:55:44	5	6	133	0	142	183	0	130.40	24	11.91	CHANGED	hhstllhshsp+TslYDtssshhlhshlpphl.thhst...p..........................h.shhDapFWLpslthhlp.ocpsho.h+slthlassWshhshs.c+cl.....................................lc..aLlppphah+hF.HWs.hVRshFh+LLlaRlh	...............................h.hsthlphhhp+TslaDtsushhlh-hlcchl..hhsphppp......................................hsshhDasFalsshchhlp.ocsshs.l+slsalassWshl..sts.ccch....................................hhc.hLLspphF.c.h.F..HWsshVRshah+LLsaRl.................................................................	0	62	94	129
+8411	PF08579	RPM2		Mitochondrial ribonuclease P subunit (RPM2)	Mistry J, Wood V	anon	manual	Family	Ribonuclease P (RNase P) generates mature tRNA molecules by cleaving their 5' ends.  RPM2 is a protein subunit of the yeast mitochondrial RNase P.  It has the ability to act as transcriptional activator in the nucleus where it plays a role in defining the steady-state levels of mRNAs for some nucleus-encoded mitochondrial components [2].	27.00	27.00	27.00	27.50	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.63	0.71	-3.97	6	46	2009-01-15 18:05:59	2006-01-05 16:12:12	6	4	43	0	28	49	0	122.10	36	10.25	CHANGED	slht--sh.sWp...pDpEssLN....cpsaLpTpIcpIpssacp....csYNhINsLYQoLKRNsI.lPslclaspVLpSIscRcLDs.....ssI-sKhhpLLoCYQDIlsN+...lKPspEIYsIVlsoLL+GSlp	.........................t..........hp...p-s-ssl.....cpsaLpTp.lspIspsapp....pchNhI.sLYQuLKRNsl.lPsl-lYshVLcSlscRplDs.....ssl-sKlspLLTsYQDl.l...ssp.......lKPscEhYNIVltuLhcGSl...	0	3	14	27
+8412	PF08580	KAR9		Yeast cortical protein KAR9	Mistry J, Wood V	anon	manual	Family	The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules [1]. KAR9 localises at the shmoo tip in mating cells and at the tip of the growing bud in anaphase [1].	20.40	20.40	23.20	21.80	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	683	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.35	0.70	-13.22	0.70	-6.25	9	136	2009-01-15 18:05:59	2006-01-05 16:19:49	5	3	119	0	96	131	0	566.70	25	69.82	CHANGED	p.ppclsplspllhsphs.l.t.....l.phhsstcshhsslhphh....-Wlh-u+sllhpL.............hpslcsI-psls+hhphl-s.hts.ps.p.pc-.hs..hhslh-csoplhs......pl+shlpslKchlDhAlEapEIhcshhssLspEl-pshphsh-lpEc+atSPh....+c.hssFsL-pllcph......usp.ssp....phph.PsF..............ss.-cplhpcalpL.csplsPlcsSL.-hLP.RlspFpsRs......p.hsshtp.Lpc+apsLhccYchLpsEhppL+pEll-c+WshlFpsLscElthhh-.sl.+.lp+lpss.ph..shphp.t.thscplpshptphp+ohslIhpAhp.S..Ilscu.lushhN..........chts+W.pL.........+...phh-plLpc.psps..t..............ss.spshpohop.....s.sspsl.sssspt......sspsSpp.shss.ptt+hussL.c+hshtPs.sp..s.t............................ssssssshhps..............psPhFs................ps....cp......t.................................s..t.............sphs..S.p+..hthshoplPslu.pps.hhps............................shpRsssptSp.....h.phtspl........s.s.............................sh.+Sltp..ttpht..tp.h.ssphPsh.hpt..s......psshlspstth.phsts.....sp.cct.....l+.P	................................hspplsplopl.hs....ltt.h.....lssh.ssh+.sh.s..sst.ph.....tWh.cupphltsL.............hcsl.cpl-puls+h.pLlps.htt.-php.+.-hsp.s..s.lhp.s.sphct......pl+thLpslKppl-lAhEapElhssllsslt.Eh-ph.phhhEhcEcRato.h..........tp.hsh.pLEpllcph.........................t.....t..tsp...................ph.ph...Phh...................st--p...phLsL.hu+hpPLcsSL.-hLP.hRls.FpsRs.....pphFsoup...ccLpp+ppt...L.ppa+tLpp-tcsL..+cELh-cRWsllFRshscpspphh-.ulE+sl.....tK....lpp..........s...p.........thphpt.......thscclcshpt....pps+hhssI..thhhu..llpcG.lts+hs.........t-htt+atsl.................p......t.hDth.L....pchpspp..............+c...slsp.ho...tps...tp.sh.tTsss.......sssS.pl.hhss.........hs..........t.......................p.....t.ps..p..s..s.s.......tt.pphsts..p+.s..hPt..s.s..ttp...........t........................................t.....t..............................t.p.s.hp........t.......t................................................................................h.............p..........s..hs......................p........................................................p......s..............t.ph..................s.s..h........................................................p.th..............................s......................t....................................th...................................................................................................................................................................................................	0	22	51	84
+8413	PF08581	Tup_N		Tup N-terminal	Wood V, Finn RD	anon	Pfam-B_9595 (release 19.0)	Domain	The N-terminal domain of the Tup protein has been shown to interact with the Ssn6 transcriptional co-repressor [1].	22.40	22.40	22.40	22.70	22.30	22.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.67	0.72	-3.79	20	172	2009-01-15 18:05:59	2006-01-06 11:04:59	5	8	149	6	122	173	2	74.50	42	12.30	CHANGED	RLsELLDulRpEF-shupcst.hp..ppc-YEt+..lspQlpEhphIRpoVY-LEtsHpKhKppYE-EIt+L+pELEsRstp	....................RLsELLDtlRpEF-s.sp........ppc-aEpp..lspQlpEMphIRppVYpLEpsahKhKppY...E-EIppL+pcLEsRsh............	0	40	73	109
+8415	PF08583	Cmc1	UPF0287; 	Cytochrome c oxidase biogenesis protein Cmc1 like	Mistry J, Wood V	anon	manual	Family	Cmc1 is a metallo-chaperone like protein which is known to localise to the inner mitochondrial membrane in Saccharomyces cerevisiae.  It is essential for full expression of cytochrome c oxidase and respiration [1].  Cmc1 contains two Cx9C motifs and is able to bind copper(I).  Cmc1 is thought to play a role in mitochondrial copper trafficking and transfer to cytochrome c oxidase [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.82	0.72	-4.20	52	511	2012-10-02 15:44:21	2006-01-06 11:43:59	5	6	275	0	351	549	2	68.80	21	58.80	CHANGED	h+pthcpcsh.cpCpchlpsht-Cppp..phhpshhtCpcpppthppClpphppscth........ctpcschhpc.+hc	..................hh..hpp+tp.ppCsphlp............thpcCpps......p....hh..phhst.CpctppthppCLpttttppth....................pttctchhpp.+...................................	0	101	180	284
+8416	PF08584	Ribonuc_P_40		Ribonuclease P 40kDa (Rpp40) subunit	Wood V, Finn RD	anon	Manual	Family	The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex [1].	20.20	20.20	20.70	20.50	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.65	0.70	-5.40	15	216	2009-01-15 18:05:59	2006-01-06 12:26:07	6	3	179	0	151	218	0	217.90	26	71.17	CHANGED	LppLL-.....s-FhsoaIKp...........................GshhhlS.csR.ssDNshsLhs...GpLhLpLsK-sYEcsGLpGKPschuG++th..RalVclDL+.sShthGpKuFpRlhWuhKshLs.hsssaLahphsos..uhsp.tpssshLssa...........psplhpscssppphpslhsPsLspschsspspstt.hp-......up-LhEWLGhVuls...lsssD.cs-saLSpYssP.-sssth...schlslpWpGFlsPphlhpLltslp+hh.......................ts.s.ssWhuLospGFucsslp...........GcssYTllhhssp	....................................................................hlp.tFhpthlp..............................G.phhhlo..ps.....p.s.....ssshs.lhs...GhLhLpLsK-sYEph.G.L.G+......s.........t..t......s....cc....................+a.llplsL...h......sh....sp.+ta.pRl.huhcphhs.....t.....h.....shLht.h.ss..................s.h.tth....................................................t.p.hp...p.thp...htp.l....h........P....h.t............t.t.t..................pp.......................s.-hh-WLuhs..t.......lph...ss.p.ssalSpYp.sP......pssp.h.............sphhhh.....phpG......hl.sphl..lh.t..hhp.h..........................t.....Whs.lsspuhscsslt.........................................................................................................................................................	0	51	78	117
+8417	PF08585	DUF1767		Domain of unknown function (DUF1767)	Wood V, Finn RD	anon	Manual	Domain	Eukaryotic domain of unknown function.  This domain is found to the N-terminus of the nucleic acid binding domain.	20.40	20.40	20.40	20.60	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.18	0.72	-3.71	34	333	2009-01-15 18:05:59	2006-01-06 14:33:46	7	14	209	1	245	330	0	87.50	23	16.57	CHANGED	sphLppht..ltlsspWLpphlst............s.sthspplhpphLssDl+-h..s...tssLPs..sltp..hpptpLp...........GshlLQlpplp-Iotshh.sphp	.............................................htpht..h.l.s..p.alpthhs............................s.sthspplhpphLtsDLcsh......s........tss..LPs...sltp.......hpptpLs.......................GshlL....Qlppltslutsth.pp.................	0	80	130	199
+8418	PF08586	Rsc14		RSC complex, Rsc14/Ldb7 subunit	Wood V, Finn RD	anon	Manual	Family	RSC is an ATP-dependent chromatin remodelling complex found in yeast. The RSC components Rsc7/Npl6 and Rsc14/Ldb7 interact physically and/or functionally with Rsc3, Rsc30, and Htl1 to form a module important for a broad range of RSC functions [1].	25.00	25.00	89.30	84.80	19.60	18.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.28	0.72	-3.53	5	27	2009-09-10 21:44:18	2006-01-06 14:54:42	5	1	26	0	15	19	0	100.30	60	53.69	CHANGED	huYYDVIuGLSuLE+ScpVoFospELpELT....cps--sRcsp-..ELp+s-pEcsKRVsVHGYLGG+Vuh+-AupAs.....Y-LsHTLLGGYVPRpQLESLSSsDFA	.hGYYDVlAGLSALEKSsQVsFSssELQQLT.....QQscsscKuh-ssE..so+ucsoKsKRVsVHGYLGGKVoLuDAupsp.....Y-luHoLLGuYVPRpQLEuLSSlDFu	0	1	6	12
+8419	PF08587	UBA_2		Ubiquitin associated domain (UBA) 	Mistry J, Wood V	anon	Pfam-B_10238 (Release 18.0)	Domain	This is a UBA (ubiquitin associated) domain [1].  Ubiquitin is involved in intracellular proteolysis.	21.80	21.80	22.10	22.70	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.11	0.72	-3.77	7	138	2012-10-01 23:03:33	2006-01-06 15:47:57	6	5	132	2	94	130	0	44.70	45	6.48	CHANGED	lD-sllptLSpTMGYs+D.-Ih-uLcp............sEs....NEI+DAYhLl+EN	.....lccpllscLu+TM.GYs+-.-I.-ALcp............sEP......stIKDAYhll+EN..	0	17	47	79
+8420	PF08588	DUF1769		Protein of unknown function (DUF1769)	Wood V, Finn RD	anon	Manual	Family	Family of fungal protein with unknown function.	21.10	21.10	21.20	21.80	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.51	0.72	-4.02	16	120	2009-01-15 18:05:59	2006-01-06 16:05:57	5	4	103	0	99	124	0	55.50	48	14.49	CHANGED	Gs-LlFGNDF-+PI+chlPsu.hssuh+lhp.aIDPslcGDlYuDc..PYLYuPuLuSh	.....GsDLlFGNDFD+PIRDpLPsG.hssAh+ls+WaIDPuL-GDsY.AD+..PYLYuPuLuSa................	0	34	60	86
+8421	PF08589	DUF1770		Fungal protein of unknown function (DUF1770)	Wood V, Bateman A	anon	Wood V	Family	The function of this family is unknown. These proteins are rather dissimilar except for a single strongly conserved motif (PDLRFEQ).	25.00	25.00	26.20	32.40	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.66	0.72	-3.40	12	76	2009-01-15 18:05:59	2006-01-06 16:12:56	5	1	75	0	61	73	0	97.40	42	56.10	CHANGED	ApTlQTAols+.c..............................PSPp+..................DlNssT............uAsc+p...sls...pps.s-.sDSls...........p-.s-....spp......hlpPhsRR..p.........phPPlPDLRFEQ......SYLsSIcuA-.o........................WtcVAaIT	......................................ApTlQoApIp..p..............................PSstH..................DlNPsT............AAsc+p........Plsh...t.....ps-...s-uls.................sDh.-....Ppp.........sl+.Ph.tR+..p.........pLPP...LPDLRFEQ......SYLsSIcsA-...o........................Wt+VAaIT...................................................	0	14	31	50
+8422	PF08590	DUF1771		Domain of unknown function (DUF1771)	Mistry J, Wood V	anon	Pfam-B_10757 (release 18.0)	Domain	This domain is always found adjacent to Pfam:PF01713.	22.90	22.90	23.00	23.10	22.40	22.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.04	0.72	-3.96	30	501	2009-01-15 18:05:59	2006-01-06 16:21:49	5	28	240	1	355	500	1	65.70	29	10.99	CHANGED	-Yp.....clRspAppthppRpchhpcuppAappGDt.....spA+pLSpcuKpttpphcchNcpAAptlacpsNp	..............................Yt.....chRppAtpptptRsphhp..........pAppAappGct.....ttA+tLSppG+tctpphcchscpAAc.tlacppN........	0	112	203	290
+8423	PF08591	RNR_inhib		Ribonucleotide reductase inhibitor	Wood V, Bateman A	anon	Wood V	Family	This family includes S. pombe Spd1. Spd1p inhibits fission yeast RNR activity by interacting with the Cdc22p [1].	20.10	20.10	20.30	20.70	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.55	0.72	-3.08	23	119	2009-01-15 18:05:59	2006-01-06 16:53:36	5	4	112	0	90	111	0	95.50	25	41.59	CHANGED	uuLhoVGMRlRKSVsEGYKT...p..s..............t.s.h..................shtsstt.hssphEhsPFsuh.p.s.shhspsspssss..................sshpthsSup-uhtushs	.....................ssLhoVGMRlRKuVs-GY+o....................................p..sh.................s.htshsshhssth.chhPhsu.h.phs.shhsptttsssp....................sshp..sssppt..t..t.........................................................................	0	16	44	75
+8424	PF08592	DUF1772		Domain of unknown function (DUF1772)	Wood V, Finn RD	anon	Manual	Domain	This domain is of unknown function.	24.70	24.70	24.70	24.90	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.87	0.71	-4.44	75	579	2009-01-15 18:05:59	2006-01-06 17:09:07	6	7	370	0	326	606	107	134.50	19	80.16	CHANGED	Gshhuaoshl............hPAlt......plsssptlpshpslspts....shhhsshhussshs.shlAh..............h.thts..sssshlhsuuulhllushshThhh.plPhNstL.............tthp...sstsssshh....tshhspWstaNtlRolhulhusslh.lhAh	............................................Ghhhshuhhh............hPult...................ph.ss..pt.h.l..t.th.p..t..h.pth.........shhhs.s...hhhsshhs.hhhuh..............................thtt....sss.h..h.hhsuuuhhh.lu.h..hshThhh.......sP.lN.st.L...................................................tthp.......ts.ss..s.ssth..........pphhpcWsthshlRshhs.hsuhshhhhu..........................................	0	115	217	284
+8425	PF08593	MUG2_C	DUF1773; 	Meiotically up-regulated glycoproteins C-terminal	Wood V, Bateman A	anon	Pfam-B_26890 (release 18.0)	Domain	This is the C-terminal part of some meiotically up-regulated gene products from fission yeast. The actual function is not yet known but the proteins are likely to be cell-surface glycoproteins.	25.00	25.00	25.30	26.70	20.10	24.00	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.72	0.72	-3.73	17	50	2010-01-05 10:44:21	2006-01-06 17:21:54	5	3	40	0	44	50	0	56.50	29	13.04	CHANGED	chtht+t.shp+Rp...........sthsssslP......F.sspps.pstLPslsolpDlstLSc.QhppaLpG	...................................aLau+shshs++p...........sttsssshP.........stps.pPhL..sshusIhslshLS..QlShFLsG.	0	11	27	39
+8426	PF08594	UPF0300		Uncharacterised protein family (UPF0300)	Wood V, Bateman A	anon	Pfam-B_20198 (release 18.0)	Family	This family of proteins appear to be specific to S. pombe.	25.00	25.00	126.50	125.80	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.32	0.70	-5.41	6	9	2009-01-15 18:05:59	2006-01-06 17:25:57	5	1	2	0	9	11	0	209.40	25	43.02	CHANGED	hhLpsppssaccLspaLpsGphPLpVLlHHVMLYcaYPsshQ-ALWsAVppYVpppVssstYTplHhhAspp+IGcIRMYLVcPcDIYshsssssWlsIsocsFpshlcLcpshptsslhpspsthpp..lhps.spSspEluWLhhhhulGSsuutFPlHAYLshKpplhpshlPcpl...hhhpcsDptlFpc.pshcchpsa.hpplhpDLshC-pap	.....h....t..pshpplh.aLpssphPlpVLlHHVMLYchYPptlp-uLWpAVppYlpcpsssttYoclHhhAAp++lGcIRhYLlcPcDlaslsssssWlsIsscpFps.lcLcpsh.spslhpppsthpp..lhph.ssospEluWLthlhuhGssupuFPlHsYLsspppl.tphhPpsh...hahpppDphlFps.tshc.hpsa.hpphhp-L..C-p........................	0	6	6	9
+8427	PF08595	RXT2_N		RXT2-like, N-terminal	Wood V, Finn RD	anon	Manual	Family	The family represents the N-terminal region of RXT2-like proteins.  In S. cerevisiae, RXT2 has been demonstrated to be involved in conjugation with cellular fusion (mating) and invasive growth [1].  A high throughput localisation study has localised RXT2 to the nucleus [2].	21.10	21.10	21.50	23.40	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.92	0.71	-4.41	17	118	2009-09-10 20:49:02	2006-01-09 16:37:06	6	2	111	0	90	121	0	136.40	32	32.14	CHANGED	soNRGsKLhppuc.l..ttl..ssssshhpchlpYs..Ghp+tlLp.....................pttsphcp-ts-h-stpp---.-pctp.t.....sPhpplclcElLuPLspsu-lhsHPulS+sapSpsLpcLAhphlthlcpEQsslhphp+LLplhlGD	.......................s.oNRGNKLptpu..chVppttL..ssstshhcctl-as....Ghp+..p..lLp...........................................pssshhDp-ss-l.D.....--.....-p...pc...spt.tst-.-sPasplplc........clLuPLppso-ls.sHPslS+sa...pScsLppLspphhthlcpEptsLhphppLhphhlGD...................	0	18	46	75
+8428	PF08596	Lgl_C		Lethal giant larvae(Lgl) like, C-terminal	Wood V, Finn RD	anon	Manual	Family	The Lethal giant larvae (Lgl) tumour suppressor family is conserved from yeast to mammals.  The Lgl family functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface [1].  The N-terminal half of Lgl members contains WD40 repeats (see Pfam:PF00400), while the C-terminal half appears specific to the family [1].	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.11	0.70	-6.00	13	313	2012-10-05 17:30:43	2006-01-10 12:04:56	5	10	193	1	188	340	0	278.70	24	27.85	CHANGED	slslsplShAs-otELuVuhpoG-VllaKFps..............Nphas...ptpssuh-hp.tphphssp.sstLlDIpcRusssl+pG..FhPhollphp.pGploulppSNIGFVAlGYcsGollllDh.RGPAlIap.-slpc..........lsstpouhsss......lEFuIMphssDsYSSIlllsGTst.GpLhTFKIlPsusGtFsVpFssss...........hsscupIlpIssl......ss-sGpSAhAohsthQ.....sLupGlhlsGhVlsooss-IRllpsspoKssHKsa.chsltssuhuhlsh.t....cppuhlLlsLhtsGpl+sholPsL+EltshplP........hslcuphlppSsl.LtsGD.lhhpsG.pEusLholhsppupt......................tppsspDpLaNssttIPsRPp...lssLQWs+G.otYsosp-LDhLlGGssR.PsSK	.....................................................................................................................................p...........................................................................................................................................................................................................................................................................................................hhhspt..u.hhh..h.h...............t.......h........................................t....h..h......................................................t.p..ptht.......pt..h..sll....so..ccph+l.hshs.s.pp....s..sa.Kth.....cs..shhspu..ssV..h.............hpsuhsLsshh.usGc.lhshSlPu.L+.lhcsphh........shh.chchs.p...shsh..ossGp.slhhs.uPo.....E......lphl......oh.tpst.............................................................................................................................................	0	45	83	135
+8429	PF08597	eIF3_subunit		Translation initiation factor eIF3 subunit	Mistry J, Wood V	anon	manual	Family	This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3).  In yeast it is called Hcr1.  The Saccharomyces cerevisiae protein Swiss:Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p [1][2].	27.20	27.20	28.10	27.50	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.88	0.70	-4.81	40	373	2009-01-15 18:05:59	2006-01-10 13:30:36	5	9	290	5	256	351	2	229.00	27	92.17	CHANGED	M....ssW.D........---h-sssssst.......ssts+W--E...s---slh-SW-..t---pct..cppcsp.tsscspsKtphctchpccp+tpchppccthc............p.sst-phscKtRh++hpc-uDLpsAt-LFG.......................................htssshsslshF.pPpoKp-FpchpcsLspp.lssh..c.pshpYss.ahp-LlRslstsLssssl+KlsooLssLhsEK.KtEKtuc...............sspKKputsts+sslssttcp.stasthssshhDD.....DDFM	.......................................................................pW..-........tpt.p....................hppa-sE......--psl......h-.s.....W-.............tp--pc..........pp........t...p......st.......t....st.......h.p.tKt..th.tt...pht....c+pptpch....tpcph.t....................p.ssp-phsc+h+hc+hpc-uDL.ptAp-.hFG.........................................................t...ssshpslshh.pP.po+p-Fpchsch...Lssp.lsth...pcsh.pYss..alcslh+plsts.....L...p.ss-.......l.KKlsso.LsslssEK.K.pEKtuc.................tttK.K.pst...st.........spsph.s....s...pp....sh....s.s.h.sth....t..s..s.....hh.-D.........-D.FM....................	0	93	144	207
+8430	PF08598	Sds3		Sds3-like	Wood V, Finn RD	anon	Manual	Family	Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins [1].\	    This family represents the conserved region found in Sds3, Dep1 and BRMS1-homologue p40 proteins.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.38	0.71	-4.79	54	585	2009-01-15 18:05:59	2006-01-10 13:48:35	6	6	246	2	375	547	0	209.60	23	51.78	CHANGED	ppshsclsplEppFsph+-ph................Yc-+LspLppcLp.lt..p.........................................Gsps-ahchhpclpcp+chclphsphhpcaplpslcpchps-hptscpcappphppl+-plhsclpp+ht+.lpc-RpphDls........................ssshshph...................................................................hps+phpct...sp.h................................................................................................................p+p+hsptts.htt...hh.........................l................................................................................................hpsp-lt-Dhpsh	..............................................h.pph.plEcpFsp.....h+-ph.................Yc-+LspL.ppcLpplt....p.................................................................sptsEYhc.lppLppphch+l.....phs.t.h.hp..php.lpslcpcattEhptuppcacppthtl+-plhsclpc+...hpc.l...pc-.+p.sh-ls.................ssphthp.......................................................................................................ht.pR.hpp.t...........................................................................................................................................ppp+hs..st............h....................................................h....................................................................................................................................................................Lp..-l.pDht.........................................................................................................................................................................................................	0	102	177	287
+8431	PF08599	Nbs1_C	Nbs1_N; 	DNA damage repair protein Nbs1	Mistry J	anon	manual	Family	This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1 [1][2].	25.00	25.00	25.30	40.60	24.40	23.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.04	0.72	-4.06	5	81	2009-01-15 18:05:59	2006-01-10 13:57:02	5	6	52	0	33	71	0	64.30	74	8.88	CHANGED	pKNFK+FRKVsYPGAGuLPcIIGGSDLlAHsR+KNSELEEWLRQElEEQsQpsREESLADDLFRY	L.KNFKKFKKVsYPGA.G..K.LPHIIGGSDLIAHHARKNo.ELEEWLRQEMEVQsQ+AKEESLADDLFRY............	0	4	6	14
+8432	PF08600	Rsm1		Rsm1-like	Mistry J, Wood V	anon	manual	Domain	Rsm1 is a protein involved in mRNA export from the nucleus [1]	20.90	20.90	20.90	20.90	20.50	20.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.50	0.72	-4.13	11	189	2012-10-01 20:49:39	2006-01-10 16:15:18	5	7	140	0	130	193	0	89.60	23	20.42	CHANGED	AhhLAhhGW.............suhscuphG.....LssCssCaRRLGLWMaKsKpsuths........hstLDllpEHh-aCPWhsspuQossucssttptt.t.....uGWclLspsL..........K	....................AhhLulhGW...................................p.shts...phu.........lhsCptChR+lGLWha...pthcsu.ss...............................s.s.hsshppHhpaCPahs.....p...st.p.....tp......................................................................................................	1	33	53	88
+8433	PF08601	PAP1		Transcription factor PAP1	Mistry J, Wood V	anon	Pfam-B_20528 (release 18.0)	Family	The transcription factor Pap1 regulates antioxidant-gene transcription in response to H2O2 [1].  This region is cysteine rich.  Alkylation of cysteine residues following treatment with a cysteine alkylating agent can mask the accessibility of the nuclear exporter Crm1, triggering nuclear accumulation and Pap1 dependent transcriptional expression [2].	22.70	22.70	22.80	22.90	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.50	0.70	-4.76	10	181	2009-01-15 18:05:59	2006-01-10 17:16:00	5	6	130	2	118	186	0	264.60	22	57.66	CHANGED	sS.........htss.pt.hshsstpFsh-hscFsucLstususcssslsK...........tpssstsos.........lsulpspssps.s.sssssss.sosp.ssts.sspp................sshusD..h.tsstsshps.u........sssssoossoPSsuusuasspp.ossusss.P..spSPsshtpsss...............................................hhhp.t.s.s.s.sttssssshshlDssls....sss.h-s.LFtsaREPQcsshsp.DaD.......................................ssLhs-p.shs-.hsPht..sp....s.......supssssppstssphcs...c-s--sVssuccsshLsCocIWDRIoSHPKa..u-IDIDuLCSEL+sKAKCSEsGVVlNpcDVcssLs+a	.......................................................................................ttttst..........................................................................................................................................................................................................................................................t.ss.......t......t...st.t........t..t.t...............pP...........................................................................................................................................................t.............hs....ht..........s..t..s..h.t.hppsppt.h.t..s...h................................................................sshhsct.....sc.ht....s......t..........t.................................t............sst.s..h.ht...p...hpt........pt......tpp.lsst..ttp.hpCscIW-+lp........s.hs+a..u-lDlDsLCsELptKA+CS-tG.lVlpppDlpphlt+..............................................................................................................................................	0	24	58	100
+8434	PF08602	Mgr1		Mgr1-like, i-AAA protease complex subunit	Wood V, Finn RD	anon	Manual	Family	The S. cerevisiae Mgr1 protein has been shown to be required for mitochondrial viability in yeast lacking mitochondrial DNA. It is a mitochondrial inner membrane protein, which interacts with Yme1 and is a new subunit of the i-AAA protease complex [1].	25.00	25.00	62.50	26.00	19.50	22.90	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.40	0.70	-5.44	6	63	2009-01-15 18:05:59	2006-01-10 17:48:11	5	3	43	0	40	59	0	252.20	28	91.40	CHANGED	MulaTPPupstsspD+.................SuspucsotslssstpFasR.PSLGL+LWGPLVPASDNhsGLaoLlulQoslGhhhhpRhRpL.........................................t..hlK+DIADFPoLNRFSpTpGDhah..............uPh........................hpcRFso.....h++sLallsGSlLLsQShLEhsRLThLhYDPWh-EAKsVR-KpFaNslV+aYHEGlDss+hhsKD.hsGp.hshNlPEV+QulAlsRApscApN.lopWFGPl-.YKPMoFsEaLDKlEaaL-hh-a......................hQshpptpcsthshlsplsscsptL-hh.ctNcpN++Rhc+lLcpp.p..s-lscu.uhslhhcupsp.hh...hhRulIL.tDpcsspDl-LcplWslY-PWssLAL-TuLSIKFlPos	...................ahPPst..s.s..tst.................................st.tstt.......p......phh.+.PSlGL.hWGPLsPAsDNh.uLashhshQ.hlGhhhhhhhRth................................................h.p.l..............s...........................................................................................................................................h.......h...h.hhhGshlh.tShLEhsRh..L.YDPWh-Ehp.hR..................................................+hthcsts...hWaGshp.YpPMshppahp+hp.alp.ht...................................h.pht....t..t....h.......hpplp..........pp.p....p.h.ph..ppspphh.p.l...........................p.s.t.ths...........ttp.............+.s.l....shp..p-.php.hh..apPW.pLt.-TphsI+hlPp....................	0	6	22	38
+8435	PF08603	CAP_C	CAP;	Adenylate cyclase associated (CAP) C terminal	Finn RD, Bateman A	anon	Prosite	Family	\N	23.80	23.80	23.80	24.00	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.87	0.71	-4.89	35	461	2012-10-02 17:34:32	2006-01-11 12:58:49	6	11	296	10	293	478	8	154.60	41	33.01	CHANGED	+cPs....phEL.cGpKWhlEp.cssp....slllp-s-hcpsVaIapCpsoslpIKG.KlNulolssCcKsullhDslVSul-llsspshplQVhGplPTIoID+oDGsplYLS+-Sl..ss.EIhouKSSplNl.l..Ps....c-sDa.pEhslPEQacoph..cs......uKLhTpss-ps	......................................tPshhEL..-GpKWhlEppcsps......slllp-.s-.hc.QslaIa+CpsoslplKG..KlNuIol......DsCc.KhulVh.DslV..u..s..lEllNspslpl..Q..........V..h........G..pVPTIoI-KoDGsplYLSc-SL...ss..EIsouKS..S-hNlhl........Ps...........t-uDa..p.................EhPlP.E..Qa+ohh...ps.......sc..LhTpss-h.....................................................	0	99	154	233
+8436	PF08604	Nup153		Nucleoporin Nup153-like	Wood V, Finn RD	anon	Pfam-B_56527 (release 19.0)	Family	This family contains both the nucleoporin Nup153 from human and Nup153 from fission yeast.  These have been demonstrated to be functionally equivalent [1].	25.00	25.00	47.40	39.50	16.40	23.50	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.97	0.70	-5.83	4	78	2009-01-15 18:05:59	2006-01-11 14:59:46	5	9	42	0	36	71	0	425.60	55	34.34	CHANGED	PoTopsu.Nas-.sLoRPoLaRuH..LsFs.L-........SsALpsQPSoSSAasIuT..SGFSLlKEIKDshSQHDDDNISTTSGFSSRASDKDlssoKssSlPsLWSPEs-RSpShspsoppSsKKPuFNLSuFGo.Ssu.GNsSlLs.opLGDSPFYPGKTTYtGAAAs.RSSRhR.sTPYQAPlRRQhKAKPhu.uQ.hGVTSusARRILQSLE+MSSPLADA+RIPu.ssSsL...Spsh-p.slDh.c..uK+cKhD..hPPVQRLsTPpshslusNRShahKPoLTPuus.ptsscclDp..sspsts+cssL.tps.cppp.......huYPhhSoPAuNulos....GGGKMpRE+soa.huoK.hp.EEl.-sPlLPcIsLPl.oosuLPoFsFoosphosT.p.oPlshso.A.oppsphps....sSs.FoFSSPIVKST..cuss.sPS.Shsho...FSVPshKh...scsouscshl.slhpstss+sAssposssc-.....p.Ghh+PAKTLKpGSVLDhL+oPGF.SSPs.pssAsp.sssoP	.................................................................PSTopou.NasD.VLoRPoLaRSH..LshohL-........SsuLaCQPSTSSAhsIGo.....SGFSLVKEIKDSTSQHDDDNISTTSGFSSR..ASDK.DlsVSKssSlP....LW.S....PEs-...RS+..S......lSQpouoSSKKPAF.NLSAFGoLSsSLGNoSlLpoSQLGDSPFYPGKTTYGGAAAA...Rpo+hR...sTPYQ.A..P....VRRQhKAK.hs...uQuYGVT......SSTA.RRILQSLEKMSSPLADAKRIP.S...s....SSPL...sSslDRSslD.h.s.shQu.K+c+.hDSph...PPVQ+Lh.TPKslSlAsNRohYFKPSLTPuuchp+sspRl...Dp..cpsst...h.ccphhs.s..p..s...tpp.pp......shSYPp.hS.hPAuNGLoSt..............sGGGKM+.RERoph...su.oKs.E..EEh..ElPVLPcISLPI.oooSLPoFsFSSP...oso.us.S..P.ls.so....t..uhs.sclphsoss...ssuSPhFp..FSSPIVKST..pAslhPPo.S....lGFT...FSVPVAKs..........sEhs..us.s.s.h..pslh.os.ss..pc......sssls.S.sspcc....pph-GsF+PAK..hLKpGSVLDlLKoPGF.sSsphs...s.u.t..........................................	0	7	9	17
+8437	PF08605	Rad9_Rad53_bind		Fungal Rad9-like Rad53-binding	Wood V, Finn RD	anon	Manual	Family	In Saccharomyces cerevisiae the Rad9 a key adaptor protein in DNA damage checkpoint pathways.  DNA damage induces Rad9 phosphorylation, and Rad53 specifically associates with this region of Rad9, when phosphorylated, via Rad53 Pfam:PF00498 domains [1]. This region is structurally composed of a pair of TUDOR domains [1].	22.00	22.00	22.60	22.00	21.90	21.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.67	0.71	-4.37	8	79	2012-10-02 16:56:36	2006-01-11 17:18:52	5	3	79	0	58	87	0	136.30	29	10.55	CHANGED	DsuhLspsDII.tsAVWsta..shsaYPG+llup..spspst.shVcFE-Gs.h-VpssDlahLDlRIGDpVcsct...s..palVpGLcsphot-sts.........I+ClRGYsTVhL..++hpp...uG+lu.pslhp.slScIal-lppW	.......................ls.pplh...usWsth...shtaYPuphluh...sssp.p.hhVcF-Dup..tclcsps.l.+h......L-LRIGDtV+lct...s+hs.alVsGhppp...s...tss.t............lpsl+GasoVhL..Kp+ps......sG..th.spp.s.lhs.PlSpIaL-ht.W............................................	0	7	26	49
+8438	PF08606	Prp19		Prp19/Pso4-like	Wood V, Finn RD	anon	Pfam-B_6384 (release 18.0)	Domain	This regions is found specifically in PRP19-like protein.\	      The region represented by this family covers the sequence implicated in self-interaction and a coiled-coiled motif [1].  PRP19-like proteins form an oligomer that is necessary for spliceosome assembly [1].	21.50	21.50	25.60	30.70	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.16	0.72	-4.24	30	339	2009-01-15 18:05:59	2006-01-11 17:41:08	6	30	290	0	243	334	5	69.20	57	13.94	CHANGED	ssssSIPuLLoshQsEWDAlhLEsFsLRppLpps+pELSpALYppDAAsRVIARLh+E.RDpA+ptLspls	.......s.osTSIPulLpshQ......sEW.....DAlMLcoFsLRQQLppsRQELSpALYQHDAAsRVIARLpKE.+spAR-ALupl.p....................	0	90	140	203
+8439	PF08534	Redoxin		Redoxin	Mistry J	anon	manual	Domain	This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.96	0.71	-4.65	68	9684	2012-10-03 14:45:55	2006-01-12 14:51:33	5	39	3870	123	2384	24093	13509	140.60	20	71.03	CHANGED	p......sGsp..h.P..shs...............h.t.stsspshslsp.......hpGKp.hll....shhsuhasPs................Cstpt...hlpch.sphhpspusshlsl..........ssssDsh........stphhuc...........ps.shhh.hsD..t.sushscshG..h.............ts.phhllsccG..pltththssts.t........hsshpshL	....................................................................Gp...h..P....shp........................h.........t...t...s...h...p....p...h....s...h......ss.........h.p..G.K.h....hl.l.....s.h..a.s....o.........a.....s.s....s.....................Cp.t.ph.........h.p.ch....tp............t.....s.....p......s.......s......s...l...l.s..l....................................s..s...s...s..psh............................st.pa.hsp..............................................tu.h.s...h..s....h....l.........h....D..............s...s...u...p.....h....s....p.....s....h..G..l..h..........................................ts...p.s....h.l...l....c..p.sG.....pl.h.h.hphss...................................................................................................................................	1	675	1408	1941
+8441	PF08608	Wyosine_form		Wyosine base formation	Mistry J, Wood V	anon	manual	Family	Some proteins in this family appear to be important in wyosine base formation in a subset of phenylalanine specific tRNAs.  It has been proposed that they participates in converting tRNA(Phe)-m(1)G(37) to tRNA(Phe)-yW [1].	21.30	21.30	21.30	21.40	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.83	0.72	-3.86	72	579	2009-01-15 18:05:59	2006-01-12 16:46:12	7	11	497	2	327	541	82	61.60	33	12.94	CHANGED	hupPsalElKuhh..ahG.Sp....tLohsshPtap-V....h-Fsptl.p.....ht.......Yplss-pttSclsLlup	......upPsalElKu.ss..asG.Ss...ttLohs.shPhap-V....hcFs.tl.t...............................................atlss-+t+SsssLlA....................	0	95	193	273
+8442	PF08609	Fes1		Nucleotide exchange factor Fes1	Mistry J, Wood V	anon	Pfam-B_36022 (release 18.0)	Family	Fes1 is a cytosolic homologue of Sls1, an ER protein which has nucleotide exchange factor activity.  Fes1 in yeast has been shown to bind to the molecular chaperone Hsp70 and has adenyl-nucleotide exchange factor activity [1].	22.30	22.30	22.30	22.60	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.24	0.72	-3.50	17	214	2009-01-15 18:05:59	2006-01-12 17:19:00	5	9	186	0	151	200	0	92.50	33	31.88	CHANGED	M-p....LL+WSIpss..........................ssspsussssssP..............................lsPchLspLF..GGPs-AsLMKtAMtslps..scsoLEsKlIAFDNFE.LIEslDNANNl	..................................................................hppLL+WoItso............................................ts..s..tps.sps...sp.s..............................................pth.sschL.pplh.....tsPs-upLMKpu.......hp....llps........spso...lEs+hhAhDshE.LlEslDNANsl...	0	46	86	129
+8443	PF08610	Pex16		Peroxisomal membrane protein (Pex16)	Mistry J, Wood V	anon	manual	Family	Pex16 is a peripheral protein located at the matrix face of the peroxisomal membrane [1].	25.00	25.00	29.20	25.60	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.13	0.70	-5.44	18	280	2009-01-15 18:05:59	2006-01-13 09:38:16	5	9	214	0	186	267	0	296.50	26	84.37	CHANGED	hp.tYpcalhcNsss...lu...plEosl+....hloYllsGRFscuchhSEhlaoh.pLLshhpDtIlppthpp...............................................h.ts..hp+lshhLshlpasElhlEhuAc+hhG-ps+WhsllhlphhKAshRlhl.LhhppuchlhosPls.h-ccsptppt.ppptspss...............................psssashpRo....G+sl....t...Ps.t.p...ht......lspshsppshct...t..p.lst.thlAEhLaIsRPLlalluhtt........hup+S........WpPWlluhul-hhShpLhpcpcph.........osh-+tEhpRRsht.....lhaah.hRuPFY-paT+s+lhpllphl.ptlPlhullutslhDYLshWpch	......................................................................................hYppaltcNss....ss...plEosh+..........sloal...ls..G.Rats....u.chhS.EhlaohspLlshhpD....t.llppthpp........................................................s......pplhhhLphlphsE.lhhEhsA..p+h..hG.cpt..............+Whllsllphh..KA...hh......RlhL.lhhh.p..sp.h.....hsPs..ls.h-hcspt.t.tttt..........................................................................................pp.sash.Ro............shsl.pl.ss.........sshp......h..........hpphhp.tpphp............p..l.........s.......h...t.h.hAEhlaIhRPLla.hlslth................hsp+S................WpPWlluhsl-hsuh.....p.Lh...pp.t.ht..............................................othE+t..Elp+Rshh............hhhal.hRusFY-......pho.csh.l..thhphh.p.hPhhs....hlst.l.-a..hhpp........................................................................................................	0	64	101	148
+8444	PF08611	DUF1774		Fungal protein of unknown function (DUF1774)	Mistry J, Wood V	anon	manual	Family	This is a fungal family of unknown function.	22.80	22.80	23.30	23.80	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.35	0.72	-3.83	14	95	2009-01-15 18:05:59	2006-01-13 10:43:53	5	4	86	0	77	87	0	93.50	42	31.85	CHANGED	RIlANVFIWshhlhsthalhhhpDaslGaulShLhhuLultQhhhKlhALQWIFAFlIhulhhVhSlhsulsthht+chhhp.........-pERtPLLs	.....RIlANlFI..Wsh..hlaGthaIhh..hpDashGauLSlLohuLultQhh.h..K..l.IuLQWIFAFlIhulhhlhSlhsulsthhs+sh.htt......ssDpERtPLL...............	0	13	36	60
+8445	PF08612	Med20	TATA_RF; 	TATA-binding related factor (TRF) of subunit 20 of Mediator complex	Mistry J, Wood V	anon	manual	Family	This family of proteins is related to TATA-binding protein (TBP). TBP is a highly conserved RNA polymerase II general transcription factor that binds to the core promoter and initiates assembly of the preinitiation complex.  Human TRF has been shown to associate with an RNA polymerase II-SRB complex [1]. This Med20 subunit of Mediator is found in the non-essential part of the head [2].	25.00	25.00	25.00	28.10	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.61	0.70	-5.21	32	235	2009-01-15 18:05:59	2006-01-13 11:26:05	6	2	198	11	160	239	0	213.80	26	92.51	CHANGED	Msl.sh...............lhh..sssp...s.tTlsphpcpLps.tsshtGpWsl-hcha+ssspshs..........................+hhhsls.ocpPspshhlhssss...........................................................ss.sDshhphlhtKlpshapp+pslps-ssts.Ypl.....GDFhlRlGsVh.ss...sh+GlllElEa..............................................................................................sssthspstsllc-Flpph........s.sts+.sh................h.ppthspl.................................hDhshQ.Yhclhs	....................................................................................................................t................hh...sssp......s.tslp.hpcpl.p......suttt..Gpasl-hcha+ss.spshs....................s.......................+hhaslp.Sch.P.t.psFslhcsss................................................................................................shhsD.s.hshlh.hKLpshapp.+pss+l-spus.Yph...............sDFhl+lGsVp.ss...........sh+GlllElE.Y.............................................................................................tssss.hss...shpllpEFlppa............thstsp....................sshh.tpptsthh...............................................s..DshhQ.Yhchh.........................................................	0	45	76	127
+8446	PF08613	Cyclin		Cyclin	Mistry J, Wood V	anon	Pfam-B_6792 (release 18.0)	Family	This family includes many different cyclin proteins.  Members include the G1/S-specific cyclin pas1 [1], and the phosphate system cyclin PHO80/PHO85 [2].	21.00	21.00	21.00	21.00	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.84	0.71	-3.80	9	1457	2012-10-03 00:42:12	2006-01-13 14:18:39	6	13	314	4	1040	1807	12	153.60	21	39.34	CHANGED	ccllptlsthlsRhsshssssspsSppstss.ps....................................Fhsh.s................................................................PslultsYhtRlp..........+astsss.....sVhlssLlYlcRlhc.........tphp.shslsuhNh+RLhlsulhlAoKhhsDhpho.Nppau+luGlsLcELNcLElsFLhhlDFcL	..........................................................................................................................................................................................................................................................................................................................t....................................................................................................................................................................................................................................................................................................................s...h.s.....l...p.a.l.tclh........................p.hs.t.h.o..........sshlhs.....hhYl.c.Rltt....................................t......h...h.l..s..........p..........h..s..........h+..R.......l.........lls...ulhlAsK........h.......h..s..D......................h.....a....s....N....p....t....a.u........c.............l........u.........G...l.........s........h.........p..E......lNtLEhpFLh.hlsacl.....................................	0	377	618	878
+8447	PF08614	ATG16		Autophagy protein 16 (ATG16)	Mistry J, Wood V	anon	manual	Family	Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells.\	      During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway [1].	35.00	35.00	35.00	35.40	34.90	34.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.43	0.71	-4.48	16	330	2009-01-15 18:05:59	2006-01-13 14:49:26	6	13	233	8	202	320	1	170.80	25	44.66	CHANGED	W+pclhcpLppRD+hp.psap-lhpph.................ppL.-csth.th.sptLps......t.................tt..usshsssht.....t.tthhhthpt-Lsphh+ppuchtppllplssplpcpcpchtppppplpplppphppLcpcl+cLcpplpp+p+sspsLpDEltuLplphshLE-+lp+lpcENppLlpRWht+tspEA-tMNp	.................................................................W+pch.ttLp.Rsphp.th.........p....lh.th..................spLh-.+sshhph.stphp.................t...t...t..........................tt......s....t..t..st...h.t.s..s.tht....pht.....phhhphppELsphp+ppuc...........hspplhphspphpphcp..phptpptp..lsphppphspLcpchpchcpplp-hp..+t....p...........plp.DEhtuLp.....l...ph.......shhEc+hcch.......pcENpcLlpRWMtcpsp-ApthNt...............................	0	53	96	150
+8448	PF08615	RNase_H2_suC	RNase_H1_sml;	Ribonuclease H2 non-catalytic subunit (Ylr154p-like)	Wood V, Finn RD	anon	Pfam-B_36578 (release 18.0)	Family	This entry represents the non-catalytic subunit of RNase H2, which in S. cerevisiae is Ylr154p/Rnh203p Swiss:Q12338 (. Whereas bacterial and archaeal RNases H2 are active as single polypeptides, the Saccharomyces cerevisiae homologue, Rnh2Ap, when expressed in Escherichia coli, fails to produce an active RNase H2. For RNase H2 activity three proteins are required [Rnh2Ap (Rnh201p), Ydr279p (Rnh202p) and Ylr154p (Rnh203p)]. Deletion of any one of the proteins or mutations in the catalytic site in Rnh2A leads to loss of RNase H2 activity [1]. RNase H2 ia an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. It participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.	20.80	20.80	21.80	20.90	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.82	0.71	-4.33	43	277	2009-01-15 18:05:59	2006-01-13 16:09:50	6	8	240	10	196	272	0	130.50	24	66.56	CHANGED	ssplLPscIp......asGsss.sscaFps......................................................pspppspph.........................................................hpsaFRGRpLhGcplslPp.uapGhlhppspph...........................................................................scspspp.......................................................................................................hp.pupFpc..hsh......................................Ws+-shP.tssDshhcsl.cahplupsl	...................................hphLPscIp........hsG.sss..sspaFps..............................................................................................................t..ptpstth.............................................................................................................................hpshFRGRpLpGppls..lPp.GapGhVhpp.ppp.....................................................................................................................................................................................................................tptpspt................................................................................................................hpspup.F.sp..hsh.....................................................................Ws.h-phP.sssDs.hhpuh.pWhplAps..............................................	0	72	115	164
+8449	PF08616	SPA	SPB_interacting;	Stabilization of polarity axis	Mistry J, Wood V, Bateman A	anon	manual	Family	Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body [1]. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation [2]. and in S. cerevisiae it functions as a polarisation-specific docking factor [3].	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.20	0.71	-4.37	27	396	2012-10-02 14:18:06	2006-01-13 16:54:27	5	12	241	0	281	674	2	111.20	28	17.65	CHANGED	tpshLphhshhss.lhhL.hsAlLtpKRllhluhppsusp..........lspalLuhstlhss...sshhpth.tp....FPY..hslSp....l-tLpchsu..........aIsGssNPhF.....cpppph.WDllhDl-ssplhlup	................................................hhphhsshh.hp.lhh.L.aphlLhtc.lllhuss....ss..................................suEhVLuLs..u...llss...........ht.hp.th.tph........................hP...Y..hslpc.............hsch..p..t..ssu..........................................hIhGV...TNPhF.......tpphph..W.s.h.l.l..clsssph....s..........................	0	97	144	217
+8450	PF08617	CGI-121		Kinase binding protein CGI-121	Mistry J, Wood V, Bateman A	anon	manual	Domain	CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1].  PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation [2].  Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.	21.40	21.40	23.00	22.30	18.30	21.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.79	0.71	-4.56	46	397	2009-01-15 18:05:59	2006-01-13 17:30:53	5	8	349	6	278	392	48	150.60	22	83.16	CHANGED	acslpss..........t.lhp.hhttp...................thphshlsuph...................lhutp+lhtAlh+Alp................shpps.phpo+sltsEIlhpLSssppIs-ul+paGlpcs.sssllslhls.................sp.....ppthpc...lhp.hlcupth.......................shsp..t...tphsDhppl+KhYKlsstt.......................t.tpltphllsphAl+	.................................applpNs.....lhpphhttp...............................phshlsush.......................................lsshhplhsAs.+A.lp.................................sh.pps....chpo+slpoEllhsLSsspp....Is.-Ah+caGlscs..sss.llllhhs..................................pppp.hpp.......ltp.h.lcGptl.......................................................s.hpp..........phschspl+K.hYclss.t..........................t.tpl.phlhtthuh...........................................	0	83	159	233
+8451	PF08618	Opi1		Transcription factor Opi1	Mistry J, Wood V	anon	manual	Family	Opi1 is a leucine zipper containing yeast transcription factor that negatively regulates phospholipid biosynthesis [2].  It represses the expression of several UAS(INO) cis acting element containing genes and its activity is mediated by phosphorylations catalysed by protein kinase A, protein kinase C and casein kinase II [1].	20.10	20.10	20.10	20.60	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.29	0.70	-5.56	4	279	2009-01-15 18:05:59	2006-01-16 10:36:52	5	4	125	0	221	291	0	159.50	14	68.11	CHANGED	Ds-hh.tsStLstl+............................................to.thYppoKsaSPRhR.GAEhVEpsl.....PVssTlsssspcoGlEusscathpphspspsSSso..pt.pp+..................pppp....c+lpushsshp.p-tpts..o.-h......................susscss.s.sspThsshDDpposphoso...........sptsussssspppSpWQp...clhlosouLu.uMSpEShKSL+YCLphL+hAsu+LtpslstLpsslschs.....psshstshs.............tpssptp...hspplTtLKtDVluTI+pVlcVVupYAGuALPEsARNhVRpalLSLPtRWupsopoo........................................ssttP..sppstsuhsspAAp+lLsLApEuLDhhuplhsllspoL-+AEtWsE	.....................................................................................................................................................................t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	46	115	186
+8452	PF08619	Nha1_C		Alkali metal cation/H+ antiporter Nha1 C terminus	Mistry J, Wood V	anon	manual	Family	The C terminus of the plasma membrane Nha1 antiporter plays an important role in the immediate cell response to hypo-osmotic shock which prevents an execessive loss of ions and water [1].  This  domain is found with Pfam:PF00999.	23.30	23.30	23.40	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	434	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-12.81	0.70	-5.20	25	146	2009-01-15 18:05:59	2006-01-16 11:42:25	5	5	122	0	91	137	0	434.30	23	49.53	CHANGED	WMsRLP+lspsu+.ShSl+RsDTpss..sstp..t..................hs.sshs.TsGlPht.hGGhhRRh+..cccpcsts.....................sp...sshptcRcpc+cc.psthhshG...shspssh...............hPp.cttps..pt...........p.ttpttt.t........................pppsp.sptsp..sppc-ptpp......sspAYtEGcplIIEDccG-llcshclsptpsttt.............................spscs-tspcshs.....s..shtpl++plupa.shttt.......................tthc+sps..................scs+pcpsaAYphsNpIIlEsEDGEVl+RYcIs.s+sp..................sppscp....usV....ls+shohlGlcs...............................................................sppp..tp.ps.tspsppplstcpssspclhsstcsp.........................................stsspsh.sspscpplpcphsp.httsss.............t..s...pspspcDo-s-s......................................p..--ppETssER+RRLuALGphs.ssc-c-DcE	...............................................................................................WMsRLP+lpptu+.ShShp+sDsps...tp.t.sp..................hs.sshs.s.Ghs....GshhRRp+..cccptppt......................spp...ssht.p+p..cpc...thhshG...shsposh.......................................................................hPp.+p.ps...........................t..................................................................pppsttppptp.p.pp.p-pttp..........shpsYpEGcplIlEscpG-llchhchpptp.tt................................tpstspt.ttpshs..........shtph++thssh.tht.tt.......................................hp+tpp.....................tcs+.pppshAYphuNs.....lIlEsEDGEVl++Yclssctt....................spp.ps........ssl..........ls+hhohhGhps...........................................................................................................hsppph.tphpph.sspsp.....pphspp.......sss.pthht.tppc..................................................................................s.t.ttphtp.....st..t.t...t.........................t......t..s.stp-s.psps....................................................tttpptET.sERcRRLsALG.hs.s.....tpppD.......................................	0	14	45	76
+8453	PF08620	RPAP1_C		RPAP1-like, C-terminal	Wood V, Costanzo M, Finn RD	anon	Manual	Family	Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11 [1].\	  This entry represents the C-terminal region that contains the motif GLHHH. This region is conserved from yeast to humans.	21.10	21.10	21.10	29.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.39	0.72	-4.13	35	280	2009-01-15 18:05:59	2006-01-16 16:11:19	5	4	247	0	201	281	2	73.90	43	7.90	CHANGED	spphRFDFcGsLl................ssppp.....tshssppGLHHHu-sPchAGYTlsELhpLuRSohsuQRslAlpsLG+IL.h+hspt	.........h.phRFshpGpLl...................................s.p.s......hslPsphGLHHHG.--P-tAGYTltELhpLuRSslssQRslAlpsLupIlh+htt.t.........	0	64	106	161
+8454	PF08621	RPAP1_N		RPAP1-like, N-terminal	Wood V, Finn RD	anon	Manual	Family	Inhibition of RPAP1 synthesis in Saccharomyces cerevisiae results in changes in global gene expression that are similar to those caused by the loss of the RNAPII subunit Rpb11 [1].\	    This entry represents the N-terminal region of RPAP-1 that is conserved from yeast to humans.	23.30	23.30	23.30	23.80	22.50	23.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.31	0.72	-4.37	39	266	2009-09-11 10:38:13	2006-01-16 16:14:21	5	4	229	0	189	264	2	48.20	35	5.46	CHANGED	sppIcpENhppLp..............sMStpEItpEpcELhssLDPpLlphLh+Ruptcpss	........ppIccENhp+Lp..............sMS.cEIhpEppcLhspL...DPsLlphLhpRtphct..p.................	1	56	98	151
+8455	PF08622	Svf1		Svf1-like	Wood V, Finn RD	anon	Manual	Family	Family of proteins that are involved in survival during oxidative stress[1].	25.00	25.00	147.40	61.10	23.40	18.10	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.13	0.70	-5.45	28	181	2009-09-11 15:23:04	2006-01-17 13:27:54	5	2	133	0	129	169	0	327.80	39	86.05	CHANGED	TsVETQTFYFss.su.phGFsQlIaSNlh.Gl.psTsQFsh+lFsscss............c.slWpSspLcN..Fc.-tssFhA....DslulcL..............sc-usp.................YsIKusl........scculV-LshpR..hsPGFplG...csGsoaY.............GsD.psPWGoMRHsFWPRssssGTIss...........ps..............................................................psl-lps......huhFltAl.QGMKPHHAAupW.NFlsFQo.........tpaSAlhMEFTTP.SYus............TpVslGuIsccscI...lhsus................s.sslpHhpscpDspssWshPpsIcapasGpsp-..scs.ph........................................lpGsL.............tphl-RlDVMAElPsFVKsIVuuVAGTKPYIYQYs....pchslclphst........p..pEcGhhasEsTFIS	......TsVETQTFYhhs.ps.hhuhsQlIaSNlh.Gl.asssQFshKlFsscss............p.plWpSspLpNh...F................p.....-thsFhu....DslulcL..............sp-sss.....................YpIKusl........scpshVslplsR..hsPGFthG...csGsoaa.............GsD.psPWGpMRHsFWPRspspGoIss.........cc..................................................................pslchps..........huhFlhAl.QGMKPHHAAu+W.NFhsFQo................s...aSAlhMEFT.T.P.SY.us............TpVslGulscc.scl...lhsus...................s.spspHhso.ppDspssWs.PpsIcasasGpspc...sp..ps............................................lpusL.................tphl-RlDVMuElPuFlKsIVuulAGTKPYIYQas....................pphs.h..clphss................-....pEcGhhasEuTFIS..............	0	32	65	106
+8456	PF08623	TIP120		TATA-binding protein interacting (TIP20)	Mistry J, Wood V	anon	manual	Family	TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription [1].	25.80	25.80	26.20	25.80	25.00	25.70	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.02	0.71	-4.67	23	345	2009-01-15 18:05:59	2006-01-18 09:29:55	5	14	251	3	238	339	1	164.60	44	14.11	CHANGED	sLIhshL............splLPhlhs-Ttl+sELlRcVpMGPFKHplDDGLElRKsAYEslYoLL-.....oshupls...lhch.hs+lhsGLpD.cpDI+hLsplhls+L........sslssctlhp+....LD..........plspsL+ssLs.tKlKssAVKQElE+ppEhhRosL+hshsltpph.......ssspsss.............tWspahcplpps	................................LlpshL.sp.lLPhLY.sETpl+pELIREV-MGPFKHpVDDGL-lRK..........uAFEChYoLL-.............osl..spl.c..........lh-F.ls+.l.tsGL....cD..caDI+....hLsaLMLs+L........usls.PstllpR.......LD.........................pLlEsL+sTho.tK.lKssuVKQEhEKp-EhpRSshRslsuL.hpl..................spsppss.................hhppa.pplpp.s.................................................................................................................	0	79	122	186
+8457	PF08624	CRC_subunit		Chromatin remodelling complex Rsc7/Swp82 subunit	Mistry J, Wood V	anon	Pfam-B_56720 (release 18.0)	Family	This family has been identified as a subunit of chromatin remodelling complexes.  Saccharomyces cerevisiae Swiss:P32832 and its paralogue Swiss:P43554 have been identified as subunits of the RSC chromatin remodelling complex, and SWI/SNF chromatin remodelling complex respectively [1].	25.00	25.00	35.90	74.50	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.46	0.71	-4.26	22	230	2009-01-15 18:05:59	2006-01-18 11:32:37	5	3	133	0	176	233	0	138.20	50	24.36	CHANGED	hsltsDEhhls.pDPcGEp..........Klcc.GpLtGGRcY+h+TFTlh....s+G..cplYMLuTEsARsl....GaRDSYLhFppH.sLaKhlsspsEKpcLI-pslIP.....SY+uRslslVTARSlF+EFGA+lIhsG.......++ll........DDYacpcAtp....pG.s	...................h..h.sDEhhh..tDspGEp..........KVDp.GpLhGGRc.Y+sRTFsls....sRG...c+LaMLuTEsARsl....GaR.DS.YLhFpKp+pLaKIIsspsEKcDLIcp..-llP....aSY+u.R.p.IulVTARShFRpFGA+lIlsG................++Vh........DDYapscARcpG..h..................	0	41	91	147
+8458	PF08625	Utp13		Utp13 specific WD40 associated domain	Wood V, Finn RD	anon	Pfam-B_8625 (release 19.0)	Domain	Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome [1]. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end [1].	21.00	21.00	21.30	21.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.65	0.71	-4.54	35	326	2009-01-15 18:05:59	2006-01-18 11:48:04	6	20	280	0	230	328	4	140.80	32	16.82	CHANGED	EQpLpNhlpptcYpcAlhLALsLc+Ph+Lhsll....cssl..............p-ppuh....ppl-......psltpLss-Qlh.....pLLchhR-WNTNu+ssplAQtlLpslLpphsssc.Lhpls....................u.......................ltcllEuLlPY........................oERHapRl-cLlcpoYhlDYslppMs	.............................................................-QpLpNhlp.p.t.capcAltLAlpLs+PtplLslh.pshh.....................................pctpsh.....ptl-...........psltpLsp-plh.......tLLphh+cWNTNuRpsplAQtlLtsllpphsssc.lhpht...........................................u.................................hpphl-uLlsY.......................................T-RHapRlsc.Llppoahl-asltpMp...........................	0	81	128	190
+8459	PF08626	TRAPPC9-Trs120	Trs120;	Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit	Mistry J, Wood V	anon	Pfam-B_15686 (release 19.0)	Family	This region is found at the N terminal of Saccharomyces cerevisiae Trs120 protein (Swiss:Q04183).  Trs120 is a subunit of the multiprotein complex TRAPP (transport particle protein) which functions in ER to Golgi traffic [1]. Trs120 is specific to the larger TRAPP complex, TRAPP II, along with Trs65p and Trs130p(TRAPPC10). It is suggested that Trs120p is required for the stability of the Trs130p subunit, suggesting that these two proteins might interact in some way [2]. It is likely that there is a complex function for TRAPP II in multiple pathways [3].	19.30	19.30	19.40	20.00	19.10	19.20	hmmbuild  -o /dev/null HMM SEED	1185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.79	0.70	-14.13	0.70	-7.23	9	449	2012-10-04 00:47:01	2006-01-18 12:57:28	6	15	255	0	329	471	2	725.10	15	78.18	CHANGED	Mp...sthS..h.ssuplRslVlPI.GchspppFpcahphltpp.sclpLtDl...hspppps.FssQsaspGplhhcFhhus...s.p..hcDFpsaRKshslIGlssh.ps.shs.....h..hpcpYPssls.pphhhFs..Ppsp........tp.cph.shF..stsp.p..pthcolhpDlstshLhshpsa.....plol+SsssI............................................................sh.ssshsopssluS...pp..+spp+p.GR..KhhGsahLLAGph.DAhppahpAlthh+tssDhLWhuuALEGhssshVlhpaht.sh....................................spht..sshp...............................................sL.p.lphhhscll.hYppuh.p.pt...sPtlh.hEuhL+hh+hhhth..................................sph-lhphl.pshthplsphshp-phplYuthAphauslGhpRKpAFhhR.lhhth.s..........................shtt........hhttlhthhsls.pscu.phtsphtp.t...............WssLQhplLp.hlpsu.phsD...hhphsshLLppahphlssspQpplhptlppsh......hpshplshsah.P.h.hth.................l.h....t....pslsp.........spphs.tPF.asPapp......htssss.p..hhhlhs-.sphplpltNPhsF-lplpsltLssctsph.........................................................pshshuhhl..Psu.chhhLshhshpsGplpl.Ghplphhss.sthhh..s.p.......................cssp.................slpllPs.PtLplhs...............t.hossshhLh-GEppphhIplpNtu.shslsplphsh..ps.c.h.ph.h....sthh.stch..hp.....h....hp............slpPsthhphplp...................................................sstts...hpt.thllp.u.pt..-top.ah+pLslPlplslh.ulclsphchlsh..................s.p..........s..p.....ss.chpLLlL-hhNuhtc..tlp............h.h.....sshtspphhlcsststRhllPlc+h...thshs.hshPpl.ppp.hlps..thstt-chph+ch.hhhppllp+lpspW+.spsp.....pGplsl+sh..p.LssphhphL..s.lphthpl.tssppt...p.tp.................hth.ss.hhshchhlh.psppsls............hhsh..hstpsshh..p.ppplLhsGsLpph.....lpstspsshphshhh	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....R..h.hu.h.h..u....u...h.........u.....................................D..W.u.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..................................................................................................................................p.th.............................................................................................................................................................h..apsh............................................hh.t-.hth.h.l.Nsh.h.pl.lpphtl...p.h.................................................................................ps.............h...l..........t...............h.......l...hh.s............t...............G.l...l.....G..h...ht...........................................................................................................................................................h.lh...P.h.h....................................hhtGp...h.h.h.N.u....h..h.h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	116	199	276
+8460	PF08627	CRT-like		CRT-like	Mistry J, Pilcher K	anon	Pfam-B_67420 (release 18.0)	Family	This region is found in proteins related to Plasmodium falciparum chloroquine resistance transporter (CRT).	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.76	0.71	-4.21	3	27	2012-10-02 19:55:49	2006-01-19 09:12:24	5	3	19	0	16	29	3	103.40	26	25.10	CHANGED	-EKpPLLSsIN-sDD-.NapDlNlKoPlshhSNIKKcSl.p+FKsaLKNSMSKETlTILIYVVLYIlSGVINSVLLKKVMNKFTNYGFFLSQLTNYGYVPIFGAlshYKIaFTsDIPKETRsFPQaKFVI	.................................................................pthhth.......................................................tcsh.lhlhhlshlhsuVhNplLhKhhhhshpNYs.aFLsQl.TshsYlsl.aaulhhahhhhtstlsp-.hthPph+Fh.........................	0	10	13	16
+8461	PF08628	Nexin_C		Sorting nexin C terminal	Mistry J, Wood V	anon	Pfam-B_5897 (release 19.0)	Family	This region is found a the C terminal of proteins belonging to the sorting nexin family.  It is found on proteins which also contain Pfam:PF00787.	22.30	22.30	22.50	22.70	20.80	22.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.30	0.71	-3.99	24	634	2009-01-15 18:05:59	2006-01-19 10:04:24	7	21	243	0	395	596	0	110.60	26	11.49	CHANGED	WLR.Rsllshlp....phhG...sTIp+hlp-plp.plhs-cplsphlshl+-sla......PsG.........phtp.s.....R......oppp+tcscppAp..phL.hphlP-hlspllGppssppuhpplFssLQpthl	...........................................WLp.+sl.lshlp....ts.hG..........ss.lp+.h....lpcp....lp..lhs-pplsphlphl...+.-uhW...............PsG...............................htt.s........sR...........................................otpp+t.cscp.pAp....ptL.h.............shlP..-hlspll...G...ppsspcuhtclFpsLQps...........................................................	0	112	184	296
+8462	PF08629	PDE8		PDE8 phosphodiesterase	Mistry J, Vasta V	anon	Pfam-B_72889 (release 17.0)	Family	This region is found in members of the PDE8 phosphodiesterase family [1].  It is found with Pfam:PF00233.	25.00	25.00	28.30	30.80	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.33	0.72	-4.17	2	24	2009-01-15 18:05:59	2006-01-19 11:07:15	5	5	13	0	8	46	0	49.50	77	6.74	CHANGED	MGCAPSIHVSQSGVIYCRDSDESsSP+QTTolSQGsAAsL.GLFlpTDAA-s	.MGCAPSIHVSQSGVIY..CRDSDESNSP+QT.TS.VSQG..PAAPL.GLFVQTDAADA..........	0	3	4	7
+8463	PF08630	Dfp1_Him1_M		Dfp1/Him1, central region	Wood V, Finn RD	anon	Pfam-B_28140 (release 19.0)	Family	This is the middle regions described by Ogino et al [1].  This region, together with the C-terminal zinc finger (Pfam:PF07535) is essential for the mitotic and kinase activation functions of Dfp1/Him1 [1].	25.00	25.00	25.20	26.80	22.90	23.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.62	0.71	-4.34	21	135	2009-01-15 18:05:59	2006-01-19 16:09:07	5	5	127	16	103	138	0	126.30	36	19.62	CHANGED	sDl......Lt+A.+chtMKlWshEKL.pRhLpslsssppshpptp...........................tpspspssLopLLcsEKlaGsoDRDPpstRcDlpYF+..tPalYlaDlspph+PIhl+Ea...chhp.pct......aPph+sss.G+CPFls-	...........pDlL.p+A....+phshKIWuhEKl.pRhLpsltsspsstttt..................................................spspscssLspLLcsE+lhG.P.oDRDPpstpc-...lhaFK..uPalYlaDhppch+PlhlREY..........cls.pp...p-us..........WPph+sus.G+CPFlp-....................	0	26	57	89
+8464	PF08631	SPO22		Meiosis protein SPO22/ZIP4 like	Mistry J, Wood V	anon	manual	Family	SPO22/ZIP4 in yeast is a meiosis specific protein involved in sporulation [1].  It has been shown to regulate crossover distribution by promoting synaptonemal complex formation [3].	26.00	26.00	26.70	26.00	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.59	0.70	-5.32	19	164	2012-10-11 20:01:01	2006-01-20 08:51:43	5	8	135	0	108	177	0	243.10	19	29.98	CHANGED	phAhppsDhshApthhs+ucphh...hhssphstpLuchhYshGhphhppp.......shspuhphlpcuhchhph....schp..........pppsphppl+hpsLphLspshlpspstcsh.c.shchlphh...pp-hsp+.shhhLthchhhp.....httsthpc.Lpphltshshscsshphhlptht.hhspssttsstsl.hhlhs+hpssss...hhchtlhsphhhhstppp.ssp.hhcsltthls..hl.t.hspplosc.shsshhslLWspspphhptppYs.uhpahphuh.pthhh	........................uhtpschphAphhht+scthh....hhpsphh...t.pLsphhYshGhphhppp............phppuhhaLpp.uh-lh..............schp.............ptssphtph..phplLphLspsh...lphp..s...p.thtc..shphlphh...........pp-hs.p.psslhhLthclhhp..............tpthpc.Lhphlhp..h..s-.....sshphhlphhp.hhp.ps....t...t....sshth.hhlh.p+h.......pss....ts.....hhphh..llph.hhh.hppttp..s.p..lctl.................hh.....p.htp.lst......p.thpsh..hslLWpp..utp.aphppas.uhpahphu............................................................	0	24	53	85
+8465	PF08632	Zds_C	Zds1_C; 	Activator of mitotic machinery Cdc14 phosphatase activation C-term	Mistry J, Wood V	anon	Pfam-B_44907 (release 19.0)	Domain	This region of the Zds1 protein is critical for sporulation and has also been shown to suppress the calcium sensitivity of Zds1 deletions [1]. The C-terminal motif is common to both Zds1 and Zds2 proteins, both of which are putative interactors of Cdc55 and are required for the completion of mitotic exit and cytokinesis. They both contribute to timely Cdc14 activation during mitotic exit and are required downstream of separase to facilitate nucleolar Cdc14 release[2].	25.00	25.00	34.70	33.70	24.80	16.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.61	0.72	-4.57	11	139	2009-09-11 06:09:32	2006-01-20 16:03:23	5	2	123	0	104	153	0	52.40	63	5.56	CHANGED	ohSTVlMhDaRhPIpVERAIYRLSHLKLSNP+RsLRpQVLLSNFMYSYLNLVs	..........psslsh..sRFPIh.ERAIYRhuHlKLANP+RsLhpQVLLSNFMYuYLshVp.....	0	27	56	89
+8466	PF08633	Rox3		Rox3 mediator complex subunit	Mistry J, Wood V	anon	manual	Family	The mediator complex is part of the RNA polymerase II holoenzyme. Rox3 is a subunit of the mediator complex.	25.00	25.00	50.10	49.00	23.30	22.80	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.40	0.71	-3.98	13	111	2009-01-15 18:05:59	2006-01-25 16:29:35	5	2	107	0	82	105	0	192.60	34	59.81	CHANGED	YpsppPsPhpDLlslYGLsslAcpVARsss.DGpKhs+LRKSYKspIpcL..uG+Fssl.sc..Nt.GGlhshlh.............hps.utDlhpt.......hss-.hpcthpshshuhhpsPp.DW..spsVLuphcpShssthtNt......sshssschuhshsGotus.ss.stp.....t.spsKRph+Kpshu-toh.shuEth.DD...................hKRR++	......ap.stPsPppDLlslYGLsslAppVARssP.sGpKh..N+LRKSYKG+IpcL..uG+acs..ltpc......sssGGhhshhh...............................tps.sp-lhhs.........hssphhppth+shp.ht.G.hP.p..-a...psVLup.c.ohssthttt...........st.ssssh....s.h.shs...sst.t.s.ts..s.p..........t.sRscRth+KRshs-tuh.uauEua.DD....................hK+R+h...................................................	0	11	37	66
+8467	PF08634	Pet127		Mitochondrial protein Pet127	Mistry J, Wood V	anon	manual	Domain	Pet127 has been implicated in mitochondrial RNA stability and/or processing and is localised to the mitochondrial membrane [1]. The Pet127 family is part of the PD-(D/E)XK nuclease superfamily [2] including a full set of active site residues.	25.00	25.00	54.20	46.70	18.70	21.50	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.87	0.70	-5.24	11	147	2012-10-11 20:44:44	2006-01-25 16:32:47	5	4	140	0	111	154	0	272.20	48	34.04	CHANGED	aloPScDppLlclAcctpKKYsuSTSSMTSlLSQlHaLLSsaRslsh..utlSpsF..s..sppssFopss+hPoSllLp.......hpsslauIDuDK....shDp-..ILSsLGHuLEphLTsccc-Ftphh.............ppphss.t.pphs-uY+YuphGcFlhRSQLDsaDs+LP.GoGsFDLKTRAVsuIRhDhsphpps...suYcIp+hhGphESaEREYaDLIRo.AhLKYSLQARIGcMDGIFVAYHNhS+IFGFQYlPLpEhDptlHuos-pt.....................................lAssEFphShplLpKlLc	.......................YlTuS+DpsLhplApcppKKYhGSTSSMTulLS+hHaLLSsaRslsh..stl..Sp.sF....s.tpspsF.Tpht+hPuulhL+...........hccGlYu.IDuDK....phDs.t......s...l.Lo.LG+ohEKhLThsp--Fc+Yphp...............................ppp.phsttt...pst..sEsYH.....Yoph.Gc.FlMRSQLDAY..DPRLP.GoG...hFDLKTRAVsuIRhDhpphcps...hGYpIcpth..GpaESFEREYaDhIRo.AhLKYSLQsRlG+MDGIFVAaHNhpRIFGFQYlsLsEhDhtlHGppctt...................................................lGDpEF+hSlpLhsclLp...................................	0	36	67	98
+8468	PF08635	ox_reductase_C		Putative oxidoreductase C terminal	Mistry J, Wood V	anon	manual	Family	This is the C terminal of a family of putative oxidoreductases.	20.70	20.70	20.70	20.90	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.74	6	39	2012-10-02 13:21:44	2006-01-26 11:15:45	5	2	28	0	27	83	46	132.10	46	33.14	CHANGED	RYLpsVQKMKpIlcENNLpVMuTsARYssAYEHssKhsWWsKSlssGPlVEQuTHFCDLSRYFGGDVDlsTlpu+ulEWaE.sG+LoKlPlDESs.IP--pRIPRhTuAoWKYcSGAVGshpHuluLQGssYuTELEVhADGY	........................................RYLpsVQphKpllc-ssl.p.lhssh.A.RYs................sA..YtthsKssWW.s.K.u.h.s..s..G.PlVEQuTHFsDLuRYFGG.-.V-.hsoVhu+ulch.-ps...G.pLsKls..lDEot..Is.-pRlPRhTsAsWKacoGAVGshhHshsLQGpsYsspl-VhADGa.............................................................	0	19	24	27
+8469	PF08636	Pkr1		ER protein Pkr1	Mistry J, Wood V	anon	manual	Family	Pkr1 has been identified as an ER protein of unknown function.	25.00	25.00	25.40	25.00	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.58	0.72	-3.92	20	147	2009-01-15 18:05:59	2006-01-26 12:00:54	5	7	140	0	110	140	0	74.60	44	37.83	CHANGED	Mus.FlpsLWpSIFTPGsTPsLllATpsoFAAL.llLlsLlhsTt.SIHFlhL.lLuusLWholsWFltELppschp	..............Mus.FhtcLWpSIFTPGs..T..P.....s.....LllATssoFuAL.lsLhsLlhsTh..SIHFllL.hlssuLWholsWFhpELptsp..........	0	32	62	95
+8470	PF08637	NCA2		ATP synthase regulation protein NCA2	Mistry J, Wood V	anon	Pfam-B_15813 (release 19.0)	Family	NCA2 has been shown to be required for the regulation of ATP synthase subunits Atp6p and Atp8p in Saccharomyces cerevisiae [1].	20.60	20.60	20.90	23.80	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.85	0.70	-5.52	13	207	2009-09-14 08:31:22	2006-01-26 13:06:51	5	3	172	0	151	206	5	263.60	28	41.54	CHANGED	slL.hhhht..olhtlhps+ppIhpal+.ssh-slpuFhpNWVhpPlpplhcTlRasp.sSplulhSpcoLpS-h-SLpRMll-FstDppssss.......lshpplpsc....lcpGDLT.......lhchYEppl+pPlKslloGsLlRoLLIQlQKsKVDsplAlsGID+lLKSQQLlFulVuluPullIlYshhphLpphltstsphupst+hp..phpl....oLsslE.RlL.......shstp...................tt..ss-hsphph......GLLll-lpsL+phuspll..........PtshpcEW...lcDLc-Lsssshss.ss+LsllpRIa+sY	.....................................................hh...........t..h....hhpppt.pl..palp.phhpshhsFhhsWlhpPlpplhssl+cs...psphulhuppoLpu-hp......SLcRMll-Fst-p.t...................ph.ptlppp...................l.cpGDlo.................lhctYEp-l+p.P.lpshl.pGcLlRuLLIQ.................lQKsKVDlphAhsGIDplL+SQcLs....F..uhluhsPulll....hthh..ph....lpt..hhttt.pth.ptttc...h...t....ph................Lpsl-.R.lL.......p.t.........................................................................ttts..s.hph.................GLLlhplph...Lhphspthh.............................s..t.p.h..tp-a...hcDlp-L.....ps...t.h.sh..ttphpslpRlhhsY.....................................................................	0	52	93	130
+8471	PF08638	Med14	MED14; 	Mediator complex subunit MED14	Mistry J, Wood V	anon	Pfam-B_13303 (release 19.0)	Family	Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation [2][3].  This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator [5].	19.90	19.90	20.30	19.90	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.25	0.71	-5.06	29	300	2009-01-15 18:05:59	2006-01-27 09:41:35	6	6	249	0	227	324	1	186.60	31	16.21	CHANGED	shhPLutLlpphsQpsap-LsslhcpLsp.......................................t.pspsshpKKhclLpahhthRspFlKLhVLs+Wu+pup..cVs+hIDlhsal+tpphhasssh.tLssh.+psLstA+lPNsDLhTALEVLspG...phsshsshs..alssss............loscphLcpLpcLNpllphRLs.l..hpplPtph.psYcI+cGRVTFpVssEFElsLolss-s	.............................hsLuhLlphhhppsap-Lp.LhchLsp...........................................psshc+KhpllpastppRp.Fl+LlsLsKWuppus.......pV.p.+hh.p.l..sal.c.ppph.haspshppLtph..+cs.....L.spA+lPshclssAl-VLooG..........+lPsh.c..p..t.....hls.sss......................lo...pct..h.....psLp.cLNpllphRLs.........ps..plP..ph..pshp.....l...............tsGRVpFpVtsEFElsLTlhsc...............................................................	0	76	124	189
+8472	PF08639	SLD3		DNA replication regulator SLD3	Mistry J, Wood V	anon	manual	Family	The SLD3 DNA replication regulator is required for loading and maintenance of Cdc45 on chromatin during DNA replication [2].	20.00	20.00	20.10	20.30	19.10	19.40	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.74	0.70	-5.86	24	128	2009-01-15 18:05:59	2006-01-27 10:36:39	5	2	119	0	98	134	0	463.60	21	59.51	CHANGED	-.h-hlcppYhpuLYho+TulAYFsKusLuRsRshhpsspsss..................p.lhshl+phlLsscphDp+Ycts....hpshhlhtsss-s...tt.pt+pp+s.pc..pchucsthhstt.thhtp.ahtp..s.pt...tp.st........pchcchlusL+lREsQLQllLlLEhl........uL......hshssEtppstppsstsh.pp...pp+sppccKtpclsh.......................................................hL-lalDRLCIWcslpsscshhsppsps.stt....................spchppssl+cFCspVllPaausRLPchschIs+KLs...sshthsPhpppps..........ptshscsusssc.........cp.....sspppppcohp+Vho-ppt.....ttttttssL.RStTsss....hccEop.shh.sh.spsp........usl.ps+phppRplslsshutpcpsch+c.thh...cpcLcsuhsulcKss+tlsucsl.spsucK+st..................hhpslQlhATPt.ssRpcs.h........................................................s..p.t....s..................................ptspssVptTPp+	...............................................................................................................p.hp.lpppYhpsLY.........psslAYFsKusLsRh+shhp.s.pt...................t.hhphhpphllshtphDt+..acpp....htthhhhhtpspt......t..php+t.pp.......phscss..............t.t....t......................pphpphlstL+hREsQLQllLlLEll...........tL..........hth.ttc.....p.....htttp.t..t........tpp..pp.cpcpppshsh.............................................................hL-lhlDRLsIWcslttschh..tt.t....tt............................ppspp-tlpsFss-VllPaast+LPchschlpcKLt...ssht.ss.ptptp...........pptspspsssshp.......................p..................s.tpsppoh.p+shsscp................t..tth.sL.+otosss...........tlcpEsp..p..h.......s...spsc..............................usl.p.+h.hp.pRphsl...sshs.....p..tpp.c..........ppht.h............ctpLp.sAhsshp+ssRtl.sscsh..scssc++tt.............................................................s.tpslQVhATPt.tpRh.psh..........................................................................s....................................................................................................lttTP....................................................................................................................................................................................................................................	2	24	51	84
+8473	PF08640	U3_assoc_6		U3 small nucleolar RNA-associated protein 6	Mistry J, Wood V	anon	Pfam-B_8720 (release 19.0)	Family	This is a family of U3 nucleolar RNA-associated proteins which are involved in nucleolar processing of pre-18S ribosomal RNA [1].	20.90	20.90	20.90	21.30	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.84	0.72	-4.22	34	307	2009-09-11 15:26:11	2006-01-30 13:06:58	6	3	277	0	221	297	2	82.60	32	15.23	CHANGED	LEptlPELc-LccptlFo+pElppIl++RocaEa+LppRssphp..DFlpYlpYEhsL-cLhpKRtp+lt.......pppptt-auh.p..RI	...........LEphlPELcclccptlFo+..sEIppIl++RscaEa+lpp+ssphp...DalpYlpYEhsLcpLhp+Rpp+lth.......ht.p..p.sh......................................	1	79	124	183
+8474	PF08641	Mis14		Kinetochore protein Mis14 like	Mistry J, Wood V	anon	manual	Family	Mis14 is a kinetochore protein which is known to be recruited to kinetochores independently of CENP-A [1].	21.20	21.20	21.70	22.70	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.82	0.71	-4.11	14	172	2009-01-15 18:05:59	2006-01-30 13:18:49	7	2	152	0	115	161	0	138.70	20	55.64	CHANGED	phuppulplssh-hpu.....sl...hslss.s..pspchEPaDh-LstplpplapphEctsVcVAphR+ssPpphtctYs.......cpppphLpp......h-pcl.............s...t.p.s.t.t-sDtpsp.st.tpp..pthhp......htpuhsplhphp.sl	..............................................tt.slp.sths..hps.............sl..................hsh.sts.......pppchEP..aDsclptpltpLhsph--lhlclAphR+phPt+lscsht.......cstpchLpp........................hcttl................s.t.t.p.p....t......t.s...tt...........t................................................................................................	0	18	45	84
+8475	PF08642	Rxt3		Histone deacetylation protein Rxt3	Mistry J, Wood V	anon	manual	Family	Rxt3 has been shown in yeast to be required for histone deacetylation [1].	29.90	29.90	30.30	30.10	29.50	29.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.73	0.71	-3.84	13	171	2012-10-01 19:31:27	2006-01-30 14:35:38	5	3	148	0	130	169	2	109.70	34	14.56	CHANGED	lsl+Istcal................ptth....cs.hstpRplWG..TDIYTDDSDllhlLhHsGhhpsshs.p.......................+pos.sh.spspsh...us.......s.Ph.tDLcVslLlLPpLp+YtSshR.GIpSRsWs	............................hpl+lst.cl................ssth...........ppchstpptLWG..T-lYTDDSDl.lAshhHsGahpsp..hs.s...............................................................t...p......t.............tt...............s.......DLplplLlLPpL.cY.ushh.ulpSRtW.......................	0	32	76	111
+8476	PF08643	DUF1776		Fungal family of unknown function (DUF1776)	Mistry J, Groocock L	anon	manual	Family	This is a fungal family of unknown function.  One of the proteins in this family Swiss:P32792 has been localised to the mitochondria [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.85	0.70	-5.28	15	135	2012-10-10 17:06:42	2006-01-30 15:01:01	5	4	126	0	99	2683	945	275.30	30	64.76	CHANGED	ARp-VVllsGSss-PlTRslAhDL-RRGFIValsspstc-tphlcscs.p.-.IcsLslsp.......ts.shpsslscFtphlppP.hshsssp.HhLpLpullllPSLsa.ssGPltsIssuoass.lss+lLs.l.lsspullPLlpt...................ppsplIllsPoIhuuLshPaHuPEslhsuslpshhpsLscElp....hsIsVspl+LGslslu...............sssSssphuslssS-....hhsWstph+sLYussasth.tpt.shtth.........RGoolRcLaphlaDhl.sp...............sssllYsGpGuplYsa.....lucalPculls	.............................................................................................................uRp-lV.llh.G.u.sp-PlsRsluhDLE.RRG.FIV.al....s...sp....ss.-..-.........p....hl...cs.p....s.....p.D....Ics.Lhl-.........ps.phtsslpph.tphlpp........s..................sh.s.s..h..........s...........p......h.....p...Lp.u...l....l...h.lP..s.Lp...Y...so.GP.l....tsI..s.s.s.s..aschlN...o+lLhsl.hshpshLPLLpt......................................................pp.s..pl...l..lh.s.P...S.I......o.uL.s.h......P.a.p.u..s.E.s...h.s....s...s...u..l..s....uhhpsLppELp............slsVsplcL.G....sl..c..lu........................tt...t..p.....t.h..t.p.hssoc................W...........tt...+s.lYu...ssaht..hp.t..t...sh.............pGo.s.....h..R..p...L.a..hlhDhlts.........................hsss.h.h.s..G..p..G.u.hhYsh.....luphhPtshl.t...........................................................................................	0	22	52	81
+8477	PF08644	SPT16		FACT complex subunit (SPT16/CDC68)	Mistry J, Wood V	anon	Pfam-B_4478 (release 19.0)	Family	Proteins in this family are subunits the FACT complex.  The FACT complex plays a role in transcription initiation and promotes binding of TATA-binding protein (TBP) to a TATA box in chromatin [2].	25.00	25.00	31.10	29.40	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.00	0.71	-4.37	32	353	2009-01-15 18:05:59	2006-01-30 17:00:05	6	13	294	0	255	354	4	151.60	43	15.34	CHANGED	IaVDpcppolllPIhGthVPFHlsTlKNsSpspEush.sa.lRINFpsP..Gsts..sppct....hps.ssshFlKEloaRSpcsc+...........hsplhctIppLpKphppR...EsEc+chtsllp..Q-+Lhl.ps.....pcsh..pLpslalRPsh.su....++hsGsLEhHpNGhRY	.....IaVDpKtpoVllPIhGhsVPFHIsTIKNsSp.osEG-a..s..............Y.LRINFhsP...Gssh...u+p-sts......aps..ssApF...l+plTaRSpcscc...........hspshptIp-lpKchtpR...............EtEc..+EtpslVc..Q-cLlhsps.....+pss.......+L.pDl.alRPsh..ss......KRhsGsLEhHpNGhRY..............	0	90	143	212
+8478	PF08645	PNK3P		Polynucleotide kinase 3 phosphatase	Mistry J, Wood V	anon	Pfam-B_6220 (release 19.0)	Family	Polynucleotide kinase 3 phosphatases play a role in the repair of single breaks in DNA induced by DNA-damaging agents such as gamma radiation and camptothecin [3]. 	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.07	0.71	-4.79	32	1136	2012-10-03 04:19:28	2006-01-31 09:22:57	6	29	976	20	329	2109	716	164.20	32	45.94	CHANGED	Kl..AuFDLDuTLIpo+S.Gtsasp.s..........ssDWpa...h..p......l.p+LppL.hp-s...........YplVIFoNQuGlst..............spt....shpsappKlpslhcpl....slP.....ltlasAsp.c..........................................D.....haRKPpsGMWphhtcchsp.....h.lshp..pS...aaVGDAAGR..........................................................ppDaSssDttFAhNlGlpFhTPEEaF	...............................................................hhhhDhDGTLIppss...pp..a..s...s...........t.Dh..h..h...hcss................VhspLh....cL..pctG............Y+lVhlTNQcGlGo................thspt...ch-s..+...s...h....h..h..p..Ih..p.u...........Glp.................l..p..l..a..h...s.s..c...c........................................................................................s..........pCRKPK.suhlc.c.alpc.t....................h.Dht....pS............ahIGD.....thsc........................................................................................................ht..hh...............................................................................................................	0	129	192	276
+8479	PF08646	Rep_fac-A_C		Replication factor-A C terminal domain	Mistry J, Wood v	anon	Pfam-B_3457 (release 19.0)	Family	This domain is found at the C terminal of replication factor A. Replication factor A (RPA) binds single-stranded DNA and is involved in replication, repair, and recombination of DNA [1].	24.20	24.20	24.30	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.04	0.71	-4.49	33	798	2009-01-15 18:05:59	2006-01-31 09:34:27	5	48	363	3	503	733	13	135.40	23	24.30	CHANGED	aaol+Aslsal.....Kp-.shhYsACsp............sCNKKVs-p.ss...........Gp...........WRCEKCspsaspspYRYllshplsDpTGphWlTsFsEsAcplh.GhoAsELtcl+c....pssppasplhpphphppahF+l+sKp-oYs......-EpRl+hTVhslp...slcapt-ucpL	................................................hphhuslh.hl.....c..pc...s.......h..hY..ACs....................pC.s.K..K..Vhpp..ts........uh.....................apC...c.+..C..s.....p..ph...s..p...s.p..aRYh..lsh..plsDto.u....p.hhlosF..s..-s..ucplh..Ghs.A.sp.L..h..p.hpp.............ps..pt..h.tphh.p.ph....hp.pa.a..+...hps.p....ct.at......tp.+...p...h.h.t...................................................................	0	138	269	387
+8480	PF08647	BRE1		BRE1 E3 ubiquitin ligase	Mistry J, Wood V	anon	Pfam-B_35727 (release 19.0)	Family	BRE1 is an E3 ubiquitin ligase that has been shown to act as a transcriptional activator through direct activator interactions [1].	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.04	0.72	-4.01	20	193	2009-01-15 18:05:59	2006-01-31 13:57:30	6	7	177	0	138	205	0	97.20	30	12.53	CHANGED	LppELsslcpAacchpphspcKht-hpshEpphs+LssEKsKADQKYFAAM+s+DulpsEhKpLppphsKss-llppLp-....hEpphppplpshcKpl	....LppELsphppuacchpphsppKht-hsshEp+ht+LpsE.................KsKADQKYFuuh+st-shpsEl+pLptphsKss-llppLc-....sEsphpptlpshEKph.......................................................	0	39	71	111
+8481	PF08648	DUF1777		Protein of unknown function (DUF1777)	Mistry J, Wood V	anon	manual	Family	This is a family of eukaryotic proteins of unknown function. Some of the proteins in this family are putative nucleic acid binding proteins.	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.10	0.71	-12.04	0.71	-4.54	7	315	2009-09-11 17:09:29	2006-01-31 14:03:37	7	31	236	0	237	303	3	165.60	29	60.66	CHANGED	MuRSRS............Ro..c+cRRcsc.spsR-.................ccRcR-RsRSR-.RDR....+RsRsR..s.+.R.pRsRSPcR................cRSpSpS..Rc+-...Rccpcc+csc.cP......+t+.hQ..........................IscpcL-.Gcsc-ph..................-MMK.hMGF.ssFDTTKGKKVsGs.DsusVplppKR+YRQYMNR+GGFNRP..LDFhs	..............................................................................................................................Rp...ppp+.p...ptc..spp.Rc.....................p.cRc+.p.Rs...R.sR.p.....R-c............cR.s..Rp...+......s..p...+....p..Rs.+Ssp+................................................................pcsp....s...s.....t..cp.pp......Rp..p.....ppppp.pp...p........................p..p...........................................................................................................pp..t.c..hp...st........st.--h.....................................c..Mh..+.hMGF..suFsoTKsK+V...............Gs.....s..s.........u....l..p..h...pK..ppYRQYMNRpGGFNRPL....s....................................................................................................................	0	86	137	191
+8482	PF08649	DASH_Dad1		DASH complex subunit Dad1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4]. Throughout the cell cycle Dad1 remains bound to kinetochores throughout the cell cycle and its association is dependent on the Mis6 and Mal2 [5].	27.50	27.50	27.70	27.70	27.00	27.40	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.67	0.72	-4.27	11	108	2009-09-11 11:16:04	2006-01-31 17:20:58	5	3	106	0	80	107	0	57.10	48	38.23	CHANGED	pYFpcQR-lLlQEIosoh-sllsNLNsLN+SLEpSluVG+EF-sVucLWppFYsulsp	............paFEpQR-hLlpEIu.....tohEpVLsNlNpLNRSLEulI.........uVGpEFsSVpuLWSpFpssMt.t.................	0	21	45	73
+8483	PF08650	DASH_Dad4		DASH complex subunit Dad4	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	20.70	20.70	20.90	20.70	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.30	0.72	-4.07	8	105	2009-01-15 18:05:59	2006-01-31 17:22:25	5	6	102	0	82	101	1	67.70	50	63.19	CHANGED	M.ENPaEcVQsslLuRIIuNVE+LNpSVspLNQpLcclNp+N+NLElMuQhCENYpcuVpFNLEATGs+KsPL	........MEsPHEppQshLLuRIIsNVE+LNEulshlN+sLp-INhpNhNl.ElluQ.....MacNYpsNV.FpLE..ATpsh+.P.t..............	2	23	46	70
+8484	PF08651	DASH_Duo1		DASH complex subunit Duo1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	25.00	25.00	25.90	27.00	23.10	24.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.47	0.72	-4.40	16	126	2009-01-15 18:05:59	2006-01-31 17:37:22	5	3	123	0	95	124	0	76.90	39	32.01	CHANGED	tuLp+EL-pLc+INtlIEslhtsLcsup.sphpplpcoscusspLLspWhpILSQTpaspcLl.sssWpGtsp.DstshE	......uLpcELcslRpINpsIEullsoLcpup.sNhpsVscolpsussLLsoWo+ILSQTEasp+LlhsPsWpGssp.Dhhc.E.............	0	23	48	79
+8485	PF08652	RAI1		RAI1 like PD-(D/E)XK nuclease	Mistry J, Wood V	anon	Pfam-B_13095 (release 19.0)	Family	RAI1 is homologous to Caenorhabditis elegans DOM-3 and human DOM3Z and binds to a nuclear exoribonuclease [1].  It is required for 5.8S rRNA processing [1]. Profile-profile comparison tools demonstrate this to be a PD-(D/E)XK nuclease, with a full set of canonical active site signature motifs characteristic to the PD-(D/E)XK nuclease superfamily [2].	19.90	19.90	20.40	19.90	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.19	0.72	-4.19	31	357	2012-10-11 20:44:44	2006-02-01 09:27:35	6	7	232	4	253	347	1	69.10	34	17.75	CHANGED	VDslhc.tpsps..t.....................ppYVELKTopth.....ps.p...phpsFc+..KLhKhWsQSFLlGls+IlhGFRDcpthLpsl	.........................................hDsh.s..t.tt..............................tpaVELKTotth........ts.p......phpsF.c.........R...KLLKaWhQSFLlGlscIlsGFR-sc.Ghlpp.h..............	0	79	137	212
+8486	PF08653	DASH_Dam1		DASH complex subunit Dam1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4]. 	21.40	21.40	21.50	21.90	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.82	0.72	-4.20	16	130	2009-01-15 18:05:59	2006-02-01 09:35:50	5	2	126	0	97	128	0	57.70	51	23.74	CHANGED	phlhsphpcLuDuhtsLDtNhscLphIH-uLss.FNESFuoaLYGLphNuWCVDFPssP	.......s.hlpPtFuELuDuhs-L-uNhh+LphhHESLuc.FNESFASFLYGLsMNAaCVDFPcuP........	0	26	55	85
+8487	PF08654	DASH_Dad2		DASH complex subunit Dad2	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	20.70	20.70	20.80	21.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.33	0.72	-4.02	18	132	2009-01-15 18:05:59	2006-02-01 09:47:46	5	3	126	0	100	127	0	97.40	34	64.41	CHANGED	sltt+I.spK+AEL-sL+pl+chossLssQh-tLppKlushsDGTEuVAsVLuNWpsVl+uIShA....Shtlh+hsptchppst..........................PLPpsLVRI.sls	.......h...t+ltpK+tEL-sLppL+clSssLssQh-tLpp+Lsshs-GsEuVAtVhuNWp.sVlpuIshA....Shplhphspt..s.p.t......................................sLPpsLVRI.h.........................	0	29	57	89
+8488	PF08655	DASH_Ask1		DASH complex subunit Ask1	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4]. 	20.70	20.70	20.80	21.20	19.60	20.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.00	0.72	-4.15	15	126	2009-01-15 18:05:59	2006-02-01 09:56:55	5	3	124	0	95	122	0	64.40	50	14.44	CHANGED	LE+L-Q-ITLsLQ.-IDpNlSpsaplITpcIlPhlpcYupsocclh-uu..pFWKpFFEpSANVpLsua	..........LE+L-QpITLsLQ.-IDpNFS+uH+IlTssIlPhVcpYucpScsVW-uo.....+FWKpFFEsSANVsLouY.......	0	26	52	79
+8489	PF08656	DASH_Dad3		DASH complex subunit Dad3	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].	21.80	21.80	22.40	22.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.65	0.72	-4.28	17	110	2009-01-15 18:05:59	2006-02-01 12:45:57	5	2	109	0	83	108	0	79.10	45	62.12	CHANGED	LSPLEpplLpcYppLussLpp.....LsspLppL............ossssp......................tlLcsLRpLEhKhuLVhTLhKuSVYSllLppp.spptcssp	.........LoPLEQEVL-EYp+Lspshpp.....LussLppL.............ussPss..........................plLDsLRpLERKhuLVhTLLKASVYSIVLQQphtttt....ts.................	0	18	44	71
+8490	PF08657	DASH_Spc34		DASH complex subunit Spc34 	Wood V, Finn RD	anon	Manual	Family	The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [1]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [2,3].  Components of the DASH complex, including Dam1, Duo1, Spc34, Dad1 and Ask1, are essential and connect the centromere to the plus end of spindle microtubules [4].	25.30	25.30	29.10	26.40	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.60	0.70	-4.72	21	142	2009-09-10 21:43:34	2006-02-01 13:01:21	5	3	120	0	104	127	0	205.80	29	85.12	CHANGED	LsppL-pIptSscuIsoL.F...ssPtIFTNAllpsp..s.........ITsLIRDs-scE.puLaphssssp..t..t.................................................tppppspc......ctshhp..............spsts.shhsphhsupsppppst..hsh..Gu.hh.p...............ht-hsl-hlLcshppLsshY.Phs..........usp-+lssLppcapplpssltpLEpcltcQpppLcpht.spppt.s.........t...................ss-c.Ic+EppEIccLEpchpplc	..............................LptpL-pIphuspuIssL.......F..........PPtIFsNAlLtst.s...........ITpLIRDspscE..psLFplsss....t.......................................................tpt.tt......pthhh................tsth....thhs.th...tspt.hpp.h..huh..Gs.hhtp.p.......................ht-hsh-llLcshp.LsslY.Pls...........shpp+lspLppcapplpsplt.hEtcltppptpLpphs..t..ttt..................................scc.lc+E.pEIcpLEtchppL...............................................	0	24	55	88
+8491	PF08658	Rad54_N		Rad54 N terminal	Mistry J, Wood V	anon	Pfam-B_26946 (release 19.0)	Family	This is the N terminal of the DNA repair protein Rad54 [1].	20.20	20.20	20.30	21.50	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.72	0.71	-11.57	0.71	-4.55	24	204	2009-01-15 18:05:59	2006-02-01 13:08:54	5	12	187	1	144	211	0	167.20	29	20.79	CHANGED	s.p.hssspShs+L..sKPFKsPh....................Suosspssc+PuRKRR..pVsYu.....ssss-ss-t.s-psh.................pscc+hALusRc...............sphsshphccp-ssh++sFoVPl...hspptssYssp+.PsPoLGhRptsshss+PLHDPouEFAIVLYDPTVDstsp............ccpptpp............cpcspcpp.c.................lcs.shh...HK..SLAEILG.....l....KKKhp.chPcV	.................................................................................t........................................................Rptp....hsYt....................................h........................................ptth.uL.sp...........................hhs.s...p.tt..hcplhp+sFpVPl.....p..s.s...Y.sspt..ss.sLGh+psshhls+PLHDPhsEaAIVLYDP.olDs...............................................................t.....................................................................p...........p+.oLtclLG................p.pt...thP.l.................................	0	40	71	115
+8492	PF08659	KR		KR domain	Hoof I, Finn RD	anon	Hoof I	Family	This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group [1].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.88	0.71	-4.62	85	6808	2012-10-10 17:06:42	2006-02-01 14:48:52	5	1300	1204	23	2532	84357	23197	179.60	32	8.62	CHANGED	GoYLlTGGhGG...LGttlAcaLs.c....+G.AccLlLsuRs...............sssspsp.....t............hl....ppLps.h.Gs....plphhssD..luctsslppl...lsplptph...sslcGVlHuAullp.Ds.hltphospchppVlusKVpGshsLcchhts.......psLDFFllaSSluu.lhGss..GQusYAAANuFLDAhAptRcspGhs......uhSlsWGhWtss	...................................................................................ush.LlT..G....G.......h....G...u.......lG..h...h.......l.A...........c.a..L....s....p...........c....G....s.....p.........c...........l.....l......L.....h..uRp...................................................................s.s.t..s.t..........t..................................................hl.......p..c....L....p...t......h.....G..s.....................p.l.....p.....h................h...s.........s....D......l....u....D......t........s........s...........l........t....t....l.............l......s......p.......l............t...........t............ph.......................s........l.................s.......G.......V.......l...H.......u...........A...........G.................l................l.................c........D................u.........h................l............t................s................h............o........................c.........p.........h.........p.........p.........V.........h.........t.............s..........K........l...........p........G........u...........h.........p.........L......c.....c.....h.....s.ts.............................ts.L......c.......h.........F.....l.......l...F....S.....S...........h...u....u........l....h.....G........s.....s............G....Q........u......s......Y.......A....A....A....N.....u....a....L....D....u....l....A....p....t....R.....+.....s....p....G..h.s.......................uh.o.l.sWGhWtp.s......................................................................................................................................	0	634	1473	2142
+8493	PF08660	Alg14		Oligosaccharide biosynthesis protein Alg14 like	Mistry J, Wood V	anon	Pfam-B_12992 (release 19.0)	Family	Alg14 is involved dolichol-linked oligosaccharide biosynthesis and anchors the catalytic subunit Alg13 to the ER membrane [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.22	0.71	-4.26	35	618	2012-10-03 16:42:30	2006-02-01 15:15:23	6	10	514	0	296	1021	447	156.50	28	77.72	CHANGED	lhllhGSGGHTuEMhcLlpth...........pshcpahlutsDshStpphp.....ht.p................hhplsRuRpVtpuhhpo...lhoslhsh.htuhhll........h+.+...........PclllsNGPGssVPlshhuhLhthhh..............................ps+llYlEShuRVpsLSLSG+lLh..h.uDhFlVQW.pLpcp.....Y.s+upY...h.Ghl	.......................................................................hllhuS.GGHhschhtLhthh...............p.cpahls.scp.utp............................................................................hhph......+...s.t...p.l.t.ps..h..hps......lhsh....l....hsh.hhuhhll...........h+..+................................PDlllssGsusslPhhhhuhlh.................................................................ts+hlYl.EShsRlpphSLoGKllh...l..sDh.FlVQW.phtch......Y...s+u..h.h.G......................................................	0	99	171	240
+8494	PF08661	Rep_fac-A_3		Replication factor A protein 3	Mistry J, Wood V	anon	manual	Family	Replication factor A is involved in eukaryotic DNA replication, recombination and repair.	23.50	23.20	23.70	24.40	23.40	23.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.26	0.72	-4.15	22	305	2012-10-03 20:18:03	2006-02-01 15:55:35	6	3	260	14	216	294	2	107.40	23	87.79	CHANGED	Ms....tsssRlssuhLppa........hupsVRllu+Vpphc..uphhlhpsssst............slplphssshph..sshl.EllGpsssss......slcshshh.-hup..shDhshhsplhplspch..pha	................t.....sssRlssshL..s..p..a.........huc.sVpllG+V..pp..lc...Gp..thhlsss.-st............sls.lpl........s....p.s.h..ph...t..h.s.s...hl.EllGpV..ssst...............slphhtht..-hus...shDhphhspllcls.p.ch..tha...........................................	0	71	118	178
+8495	PF08662	eIF2A		Eukaryotic translation initiation factor eIF2A	Mistry J, Wood V	anon	Pfam-B_7957 (release 19.0)	Family	This is a family of eukaryotic translation initiation factors.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.13	0.71	-4.60	22	1027	2012-10-05 17:30:43	2006-02-01 16:42:42	6	49	446	0	624	2639	160	177.20	24	29.09	CHANGED	KsFFpu-csphhWNppGssLLlhss...TchDKospSYYGppsLahl......thsss.sshlpLspcGs.IaDhsWsPpucEFsVlaG..hMPu.csshash.....c....sssltshspps+NolhasPpG+hlllAGFGNLs.Gpl-h.aDhp..phcpluphcssssohs-WsPsGcallTAoTuPRlRl-NGaKIWpasGpLlaphph...sELapl	.........................................................................................shhpsspsphhW..ptt..uphlhhhsp..........ch.s..p.s.t.....p........shh..s...p.............plah..h......................t.t.t..t.h......s....t.h.lp..l........p.c.p.t.s.....l.h.s..h..sW.............p...P.............s............u........pc.......F....s......l.....l............h...........G.............h.s.............t.........pl..........sha.sh........................c..................sp..h...l...t...s...h...t....p...p......s.....t.....N.......s.......l....h...a....S..P.p.G........p...h.l.l.l.....u.u......h....t..............s....h...p........G.p..l.p....h...aD...........h.............p.................p..............h..........p.....h................h..............s.........p...h........c.....t.......................s....s...........o....s..h...p......Ws..P.sG.+......al.h.....o.....u.....s...s.........s........................p...h....p...h...p...N.........G.hpla.p.h.p.G.t..h.p..h....tth.....................................................................................	0	222	347	511
+8496	PF08663	HalX		HalX domain	Bateman A, Galperin M	anon	Galperin M	Domain	HalX is a domain of unknown function, previously (mis)annotated as HoxA-like transcriptional regulator.	23.30	23.30	23.60	23.60	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.31	0.72	-3.99	13	74	2009-01-15 18:05:59	2006-03-07 15:01:53	5	4	22	0	47	76	0	69.40	28	34.79	CHANGED	lsRs-YD-plpEhaALsSKpAsLEupKssspLpsS-cYscLp-Rl-pLcscl-ssssphssp.Dacuhhpsh	........pRspY-cplpEhauLsuK+AsLEspKsps-Lpcs-cYpcLpsRlccLcspl-psh.sph..psp.Dh.thh..................	0	3	32	47
+8497	PF08664	YcbB		YcbB domain	Bateman A, Galperin M	anon	Galperin M	Domain	YcbB is a DNA-binding domain [1].	25.00	25.00	26.10	75.80	20.20	24.30	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.59	0.71	-4.37	21	318	2009-01-15 18:05:59	2006-03-07 15:12:28	5	2	240	0	48	218	1	134.50	43	44.99	CHANGED	cphphlLu-LGIsGEuGucDllpllphlhcppps.s.......sLKplFpcluppc.....t..chp+EhKAhEQRIRRAlhpuLsplAuLGlsDasNspFcpYAsphFDFpsV+pcMpclpscsst...pu+lNlKKFlpsL	........s.ph+aLLSELGIuGEsGS+DLlshl-YLhppEpspo.....thPuLK-lFpplst++Ls...s.ts-lc+phKAuEQRIRRAIhpuLsHLASLGLTDFpNPKFEsYAs+FFDFssVR++MsElppcpst.........tsRIssKKFIQVL.	0	21	37	41
+8498	PF08665	PglZ		PglZ domain	Bateman A, Galperin M	anon	Galperin M	Domain	This family is a member of the Alkaline phosphatase clan.	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.19	0.71	-4.61	16	530	2012-10-03 20:55:17	2006-03-07 15:56:20	7	2	502	0	158	551	302	178.40	25	24.53	CHANGED	cRVhVIlSDAhRaEhupELtphLNpcsphps-l..p.......shhulLPSYTpLGMAALLPHctltat..tstsVhVDGpsspuhtpRptILtphh......uhAhptc-lhshspccsR-......hl+spcllYlYHNpIDuhGD.....+tsoEppsF-Ascpslp........pLpcLlphlhsp.sGsplhlTADHGFlapcssl	........................................................................+lhlIlsDuhRY-ht.ppL.tp.p...l.s.p..p.p...p..h.phch....p..................shhuhLPohTphuhs.Alhs.....s..p.....h......p...h...........t....t...t.sp..h..hs..-.....s.p.p.p.p.s.h.s.....t.+.p..p..h.Lpt...........................shshp..hc..clhs.h.pp..sctpp.........hhp..sp...c...llhlh...a.NtI..Dt.huc.........p.h.p.Et.....t.s..hc......us.......h.....cul.s...........tLtcllppltst....s.h.c.lllTuDHGalhppp..h..................................................	0	72	122	146
+8499	PF08666	SAF		SAF domain	Bateman A, Lakshminarayan I	anon	Lakshminarayan I	Domain	This domain family includes a range of different proteins. Such as antifreeze proteins and flagellar FlgA proteins, and CpaB pilus proteins.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.85	0.72	-3.57	169	4935	2012-10-01 20:51:14	2006-03-07 16:09:21	7	24	2605	28	1282	4640	2751	65.60	23	18.28	CHANGED	psllluscs..lttGphl.........sspslphtpss...h.huhhspt................hspllG.....thstpslttGphlphsplp	..................................plslA.hp-..lttGphl.....................stps..lp..h..t..p..s..s....hthultsht............................................aspl.l.G.......hAtpslttGphlp.ptl...............................................	0	427	825	1065
+8500	PF08667	BetR		BetR domain	Bateman A, Galperin M	anon	Galperin M	Domain	This family includes an N-terminal helix-turn-helix domain.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.80	0.71	-4.26	6	180	2012-10-04 14:01:12	2006-03-07 16:15:43	5	3	131	0	45	208	4	118.90	32	49.44	CHANGED	sschlsss+lRcLLs+pGIucRp+sohIsplLGLShSsupRKL+GuhPWsLuQLp+lAptaGhPsu.LL....-spGhsP............ss-hpDAlLshpspchpC+............AhI...uspusupspspFVAhp...pspWhVht+scs.-p....csYsVchl-lps	......................................s..phhhup+V+cLhs+pGIs.Rpp.s.o.plsclLsLSaSsu.pRK.L+.GpsPWoLuQlpclActaG.s...supLh.....ssp......................pAhh..t..ph.Ch............hhl...st...s.t..s.h.A.p......W.lh.hpth..t.....ha.sch....................................................................................................................	0	5	12	28
+8501	PF08668	HDOD		HDOD domain	Bateman A, Galperin M	anon	Galperin M	Domain	\N	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.07	0.71	-5.03	57	3180	2012-10-01 20:28:14	2006-03-07 17:06:09	7	42	890	11	1179	4044	485	178.50	20	48.05	CHANGED	LPslPslhhclhphl.psPssshsclAclIspDssLoA+lL+luNSshau..hsppls.olppAls.hLGhpplpsLsluhulhphhpst......hhchpthWc+SltsuhhuctlApth......shtp.s..-csahuGLLHDlGclhlhphhscthttlhphhtttt..shhpsEcchhGhsHsp.........lGuhLhcpWphPttlscslthH+ps	....................................................P.hsthhhclhphh...s..p..s..s.s..s.h..p........clscllppDssLosclL+h..s.N....S....s....has.........hs..p.......p......ls....ol..p.p...Als.hL..Ghpp..l..c.s..l.l.h.s.h..s.l..t.p.hhptts...............h....pph.a.p..p.....uh.t.....s.At.h.s.p.h..l.u.p.p.h................sh..tt.............-p.sa...h...s..GLlpslG.h.h.h.h.t........h........t.....h.................h...................................................................h......t......t..h..h......t.h.......h.................hs....l.h.t....W.t..h...s....hh..t.h.............................................................................................	0	403	849	1049
+8502	PF08669	GCV_T_C		Glycine cleavage T-protein C-terminal barrel domain	Bashton M, Bateman A	anon	Pfam-B_933 (release 4.0)	Domain	This is a family of glycine cleavage T-proteins, part of the glycine  cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase. 	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.25	0.72	-3.96	190	6206	2009-01-15 18:05:59	2006-03-08 14:03:29	6	31	3260	45	2055	5279	10043	94.50	25	19.51	CHANGED	ssFlGp-ul..tctpp.p......u........++hlul....................hp..t.shsptGttlht................ss.....ptlGtlTSusaussl.tpsluluhl...............sstsp..Gs...pl.plp.l.....................cu..pthsupl..sph	........................................................................sFlG+csl...tppcp..p...................G............s.....++lVGL.........................................thp...scs...s..s...cs..G...t..t..lht.............................................ss..........ptlGhlTS.G..sh.S..Pol......st..s..IAlAhl.t.............tth.sth..Gp....pl..l.p..l......................cs..cth.spls..............................................................	0	599	1224	1672
+8503	PF08670	MEKHLA		MEKHLA domain	Burglin T, Bateman A	anon	Burglin T	Domain	The MEKHLA domain shares similarity with the PAS domain and is found in the 3' end of plant HD-ZIP III homeobox genes, and bacterial proteins.	23.70	23.70	23.90	26.80	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.53	0.71	-4.67	26	387	2012-10-04 01:10:46	2006-03-08 17:08:34	6	5	225	0	141	393	60	143.80	34	29.20	CHANGED	PEshsLsphlspSYp.....pahGtsLlps.ps..uscshhctLac.pspulLspuhc..ssPlFsaANpuuLchhEs.ohssLpcls.chhh-.cssRcshssthsclhpQGasph.uGlplSshGRphphEpAssWplLss-p....sscs.AhhFsNWpFl	................................................shshsphlspSY+.........thhGt.pLlpsttt........sspphhchLac.t.s.Allspuhc.........spP.lFsaANpuuLchhEh...ohstLpsls.chsh..-...p...ss...R.cphp.s.h.splhpQ...Gas....ph..uGlplSshGRphph-pAlsWpl.ls....c-s......sh+s.AhhFhsWph.......................................................	0	29	90	116
+8504	PF08671	SinI		Anti-repressor SinI	Mistry J	anon	pdb_1b0n	Domain	SinR is a pleiotropic regulator of several late growth processes. It is a tetrameric DNA binding protein whose activity is down-regulated thorough the formation of a SinI:SinR protein complex.  When complexed with SinI, the SinR tetramer is disrupted such that is no longer able to bind DNA.	19.80	19.80	19.80	20.80	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.94	0.72	-7.11	0.72	-4.51	17	297	2009-01-15 18:05:59	2006-04-20 09:18:08	5	4	127	4	39	164	15	29.60	46	35.33	CHANGED	LDpEWhpLlpEAhctGlohE-h+cFLphpK	..LDpEWhpLlp-AhsuGlohcphRcFLch.K........	1	7	20	25
+8505	PF08672	APC2		Anaphase promoting complex (APC) subunit 2	Mistry J	anon	pdb_1ldd	Domain	The anaphase promoting complex or cyclosome (APC2) is an E3 ubiquitin ligase which is part of the SCF family of ubiquitin ligases.  Ubiquitin ligases catalyse the transfer of ubiquitin from the ubiquitin conjugating enzyme (E2), to the substrate protein.	20.30	20.30	20.30	20.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.89	0.72	-3.71	18	240	2009-01-15 18:05:59	2006-04-20 09:25:36	6	4	216	4	176	238	3	59.20	40	7.61	CHANGED	YIhuMLTNhso.LsL-RIHsMLKhh...ss.sshshopcELccFLsphVcEp+Lphs.GGsY+L	...............aIhGMLT.Nhsu..hsL-RIapMLKhh...ss.sshsho.pELppFLsphVp-tcLphs.uGsY+l........	0	56	90	143
+8506	PF08673	RsbU_N		Phosphoserine phosphatase RsbU, N-terminal domain	Mistry J	anon	pdb_1w53	Domain	RsbU is a phosphoserine phosphatase which acts as a positive regulator of the general stress-response factor of gram positive organisms, sigma-B.  The phosphatase activity of RsbU is stimulated by association with the RsbT kinase.  Deletions in the N terminal domain are deleterious to the activity of RsbU [1].	23.10	23.10	23.10	23.50	21.70	23.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.37	0.72	-3.97	14	334	2009-01-15 18:05:59	2006-04-20 09:26:18	5	8	325	8	32	137	0	77.00	54	22.08	CHANGED	cppY+plLccYLtspsEpsLY.pspcho+csIc+pIsPE-IVslH+shlppl..sl.....pcplhcohDlLlEVMhGYGhAY	..cp+YKuLlcESLssQD....KspLIKKCEKaTcEVI+KDVLPEDIV-IHKsYIhoLsLo.......cEDVh+TL.DVLQEIVKGFGYSY......................	0	10	19	29
+8507	PF08674	AChE_tetra		Acetylcholinesterase tetramerisation domain	Mistry J	anon	pdb_1vzj	Domain	The acetylcholinesterase tetramerisation domain is found at the C terminus and forms a left handed superhelix.	25.00	25.00	28.10	28.10	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.04	0.72	-4.43	6	95	2009-01-15 18:05:59	2006-04-20 09:29:11	5	3	45	8	45	93	0	37.40	68	6.56	CHANGED	DEAERpWKhEFHRWSuYMh+WKsQF.DHYS+p-pCusL	.DEAERpWKAtFHRWS.sYMhcWKNQF.Dah..SKpEpCssL.......	0	5	6	17
+8508	PF08675	RNA_bind		RNA binding domain	Mistry J	anon	pdb_1whv	Domain	This domain corresponds to the RNA binding domain of Poly(A)-specific ribonuclease (PARN).	27.90	27.90	27.90	29.20	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.13	0.72	-4.00	2	85	2012-10-02 20:46:34	2006-04-20 09:35:57	6	4	61	5	49	96	0	81.40	61	14.59	CHANGED	G.-.p.pR-HlhasTFPcpW+TuDl.phFpsFGslplSWlDsTSAFVuLpp.ptsp.slph.tYtpua+l.saApa.......pQhK	........GPDLQPKRDHVLHVT.FPKEWKTSDLYQLFSAFGNIQlSWIDDTSAFVSLSQsEQVp...IAlNTS..+.Y..AESYRIQTYAEYhtpKp............................	0	12	16	32
+8509	PF08676	MutL_C		MutL C terminal dimerisation domain	Mistry J	anon	pdb_1x9z	Domain	MutL and MutS are key components of the DNA repair machinery that corrects replication errors [1].  MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation [3].	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.72	0.71	-4.59	108	4304	2009-01-15 18:05:59	2006-04-20 10:11:38	6	18	3912	12	1164	3441	773	144.10	26	22.12	CHANGED	s......h.hlu.....QlpssYllups...pcG.LhllDQHAA+.....ERlhYEpl.cpp..htp............psQ.LLlPhsl.pls.tp-hthlpcpt-tLpclGhplct....hGspslhlRslPshLtptph...ppllp-llspltphs.......p..........tthhcclhsthAC+sul+us...cpL	......................................hluQlpssY..l...l....s......p..s...............ps.....s......lhll..DQH..AAc.....ERltaEph..ppp.............hsth....................psQt..L....L....l.....P.......h....hl...cl........s..t....p-t..thlpc....p......t...s....t....L.p.c.....lG....lplp...........................husp....p....hhl+......u.l....Ph...hh...t.p...t....p..h...............p..p...l.......lh.-.lls...lhpps.....................p...........htphhpp.lht.h.huC+t.ul+ssp.........................................................................................................	1	401	726	969
+8510	PF08677	GP11		GP11 baseplate wedge protein	Mistry J	anon	pdb_1el6	Family	GP11 is a viral structural protein that connects short tail fibres to the baseplate.  The tail region is responsible for attachment to the host bacteria during infection.	20.80	20.80	21.00	79.60	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.39	0.70	-5.18	8	37	2009-09-10 20:27:43	2006-04-20 10:37:38	5	1	36	3	0	32	0	216.80	35	94.22	CHANGED	hohscsKAuVhSRcADFLta..c.suscD.sl.......hsspslGusTlsQltKGsY.PNVQSAIsDltshu.phsVGsVllsTsusuPpulpQ.s-hloFoGoVssss..sus.llIcVaGlPVpsssGsousplsspVpsshp-hlssphhhspspcc.sosuspLpl+YlDsppH.slssaoppGI..............TloppIsupu+sGYGTWshLGspTpTLssts.sss..lYYF+RIA	.....hohspstAtlhSRhAsalpac.spssshsV.......hsspsIGusolsQhtKGhhhPNVQSAIsDltshu.phPlsulllsssssuPpulpQ.sDhhoFoGoVssss..sGsslllpVaGhPVpsssGsousplsspVpstLp-hhspshhhsssppc.ssssspLplpYlDsppH.hhpsaophGI..............TlsppIss.u+sGYGsWphLGspohTLsstsssss..lYYFcRl.......................	0	0	0	0
+8511	PF08678	Rsbr_N		Rsbr N terminal	Mistry J	anon	pdb_2bnl	Domain	Rsbr is a regulator of the RNA polymerase sigma factor subunit sigma(B).\	\	    The structure of the N terminal domain belongs to the globin fold superfamily [1].	27.00	27.00	33.30	82.60	26.20	25.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.55	0.71	-4.26	9	83	2009-01-15 18:05:59	2006-04-20 11:15:30	5	2	83	6	13	59	0	130.20	46	47.84	CHANGED	Fltcpps-LlppWsspl+clsspphshplo-chaEshspEal-lll.s.sptsspphpcclp-Fup+hVQlGhsLphlosGLptFt+hlaptMtccs..hscppt..h-llhcl-calsPlssEIlNpYohSWE	..FIpsN+s-LLssWhscMccpS-QhhsslspEthYEpTSKEFVDLIl.SslTcssscasE+L--FAEKlVpLGWPl+FlTTGLpsFGhLVYTs.MpD--....LcccE+..sDhaac.h.-oWlSshhNclVstYusoWE....	0	5	10	11
+8512	PF08679	DsrD		Dissimilatory sulfite reductase D (DsrD)	Mistry J	anon	pdb_1ucr	Family	The structure of the DsrD protein has shown it to contain a winged-helix motif similar to those found in DNA binding proteins [1].  The structure suggests a possible role for DsrD in transcription of translation of genes which catalyse dissimilatory sulfite reduction.	24.20	24.20	24.50	49.10	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.02	0.72	-3.97	13	56	2009-01-15 18:05:59	2006-04-20 11:17:52	6	2	52	4	29	53	5	66.60	48	66.35	CHANGED	-hKptIl-a.....u+pusKoKaYF+Dhhch....hP-hKsRElKKllscLVsEtpLtaWSSGSTTMYGLKspG	....-hKptll-aLp...tcsssKoKFYFpDFtch....hPDtKsR-lKKllspLVsEtpLpYWSSGSTTMYGLKGsG..	0	15	28	29
+8513	PF08680	DUF1779		Protein of unknown function (DUF1779)	Mistry J	anon	pdb_2fpn	Family	This is a family of uncharacterised proteins.  The structure of the ywmB protein from Bacillus subtilis has shown it to adopt an alpha/beta fold.	25.00	25.00	25.30	25.00	23.30	24.60	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.48	0.71	-4.46	14	234	2009-01-15 18:05:59	2006-04-20 11:23:29	5	1	231	1	55	184	0	191.20	31	80.00	CHANGED	ssplpc.................Wshtu+pphshsp..ctapphspphct-htphpW..spsp-.cchtchpGshpc...thptplpll.sstpssptpoYllYEhputt...ps.s.thcph.cpshclaptcshIFoClpGphssphsts.LpppupplLcphsA+pVEsltEpsFlSlSAaoscapptIhssscc.hNlQlALRps.uhss+TplslGTPIlTsEY	...............................................................................plpp...Wshhs.+p.hshsp....ppFpphlpplct..ctph.cW......ppp.-.hctp..php...th.p.......hppclhl.....s......hopcsspppoallh-hpusc...........h..chlpph.clas...pKshlaoC.lpGhl..s..s+..lpss...L.pscsp.p.lL.+.clsA+slEplcE...cs.a.VSlSAYspcac-...s.lpospcK.lNlQlAlRps....ssKspIsVGTP.IITsEY.....	0	25	42	46
+8514	PF08681	DUF1778		Protein of unknown function (DUF1778)	Mistry J	anon	pdb_1y9b	Domain	This is a family of uncharacterised proteins.  The structure of one of the hypothetical proteins in this family has been solved and it forms a helix structure which may form interactions with DNA.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.18	0.72	-4.15	45	1442	2012-10-02 18:44:02	2006-04-20 11:29:57	6	3	878	2	236	790	75	77.30	30	79.07	CHANGED	RlshRlss-p+pLlc+AAslpG.polosFllsuAhctApcllpcpch...lpLotpshptFh.ssLsp...PspPNscLccsht......phpp	......................lslRlss-p+sllccAApltG.pslosFllpuAhp...tApcllt..cp..ch....hhLsppsapthh.phL-p.....P..s.s..s..s..ttLpphhp....p...............................................	0	60	137	192
+8515	PF08682	DUF1780		Protein of unknown function (DUF1780)	Mistry J	anon	pdb_1y0k	Family	This is a family of uncharacterised proteins.  The structure of a hypothetical protein from Pseudomonas aeruginosa has shown it to adopt an alpha/beta fold.	19.70	19.70	21.50	21.10	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.38	0.70	-4.86	2	56	2012-10-11 20:44:44	2006-04-20 11:31:19	5	1	55	1	13	39	4	202.10	81	99.11	CHANGED	s-uDaLRLLThQAEQANsFLSNARKW-RERWVCQRhLpuLNlPYRp--FsAsGppPPDVLF+tAuFEVFFVLDEGRRLN-EWR-ELpRRRpAhSLpQLlRREt+PpRIsAuEL.hRLAPTLRKKAHNYpERGhshGELDllAFssLKRtV.DhNo.FPPPTEYLRQGWRSLShVGPTFARVLFAHssAPEFLRuNLGRSILFDsGluL	.............DDSDYLRLLTlQAEQANAFLSNARKWERERWVCQRLLQGLNlsaRsEDFsPAupE..PPDVLFRDutFEVFFVLDEGRRLNDEWREELsRRRSAFSLuQLVRREA+P+RIsAuELLtRLAPTLRKKupNY+ERGIDLGcLDIIAFsSLKREVLDLNoHFPPPTEYLRQGWRSLSLVGPTFARVLFAHPGAPDFLRsNLGRSlVFDVGISL............	0	1	3	8
+8516	PF08683	CAMSAP_CKK	DUF1781; CKK;	Microtubule-binding calmodulin-regulated spectrin-associated	Mistry J, Baines A	anon	pdb_1ugj	Domain	This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.	19.60	19.60	20.30	22.30	19.00	18.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.53	0.71	-4.42	14	287	2012-10-02 14:14:57	2006-04-20 11:33:32	6	6	107	1	153	255	3	125.80	57	10.32	CHANGED	ss.cl.ahcsusKSN+slIpNAlsassLuGpsNcsp+ptlLc..clscsp...upHFlILF+..DspppaRulYoh.psps-phhKltGhG..PptlsptMlcshaKYsSusKpFptI..sKphosslDAhol.......K+	........................TGPKL.aKEPSuKSNKhIIpNAluH.CCL.A.GKVNEspKp+ILE...EhEKS-...ANHFLILFR..DuG...CQFRuLYo.......Y..sP-T..E.........E...lsKLsGhG.......P+sI.oc...pMl-tlYKYsSDRKpFopI.PuKThSsSVDAhTI....+sHLWQsK+................	2	44	60	101
+8517	PF08684	ocr		DNA mimic ocr	Mistry J	anon	pdb_1s7z	Family	The structure of an ocr protein from bacteriophage T7 has shown that this protein mimics the size and shape of a bent DNA molecule [1]. ocr has also been shown to be an inhibitor of the complex type I DNA restriction enzymes [1].	25.00	25.00	83.30	83.00	22.20	21.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.24	0.72	-3.97	3	48	2009-09-11 05:26:13	2006-04-20 11:37:54	5	1	11	3	0	48	0	97.00	83	90.53	CHANGED	MSNMTYsNVasHAYEhLKEpIRYDDIR-sDDLSDAIHEAADNAVPHYYADIFSVMASDGIDLEFEDSGLMPDTKDVT+ILQARIYEQLTIDLasDAEDLLN	.MSNMTYNNVFDHAYEMLKENIRYDDIpDT..DDLHDAIHMAADNAVPHYYADIFSVMASEGIDhEFEDSGLMPDTKDVIRILQARIYEQLTIDLW..........	0	0	0	0
+8518	PF08685	GON		GON domain	Mistry J, Rawlings ND	anon	Rawlings ND	Domain	The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins.  It contains several conserved cysteine residues.	22.60	22.60	24.80	23.10	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.68	0.71	-4.47	11	187	2009-01-15 18:05:59	2006-04-20 11:48:09	6	56	84	0	124	173	0	176.80	43	12.88	CHANGED	lspoCpElQphpuhtpDGEYhLpV..cGchl+IYCHGMpocsPpEYloLspGsp-NauphYshRLtssppCP.sGpc+psssspss..hshGtTpFsKlRlDlsshpIhssDapFupop.Gps.PauoAGDCYSss.+CPQGcFSINLpGTGh+lpssspWpspGshsshch....c+spssp+VhG+CGGaCGtChPp.poGLhLpVh	...........................................h..poCpElpt..h.p....sh..pc.......DGEYhL.l....pG+.hl...+...laCtsMpoppPKEYlTL.sp.G.p-NaSElYG.h..RL..ps.Ph...pCPaNGsRppsC..pCpps..hsAGhThFpKlRl..Dl..ss..hp..IhssDhpFApT.......G.........ps.VPaAT..A....GDCYSss.....cCP...Q..GpFSINLhGTGhplspsspWhspGp...a.ss..pl.....p+o.ssp+lhG+CGGaCG+ChPp.tsGL.lpl.h...............................	0	48	54	93
+8519	PF08686	PLAC		PLAC (protease and lacunin) domain	Mistry J, Rawlings ND	anon	Rawlings ND	Domain	The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins.  It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin [1].	26.40	26.40	26.40	26.40	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.35	0.72	-3.68	29	739	2009-01-15 18:05:59	2006-04-20 11:50:11	6	140	83	0	426	640	0	34.10	37	3.34	CHANGED	pCpDpsp........CtlVhpspLCphpaYpptCCpSCpp	...........pCpDpsp...........aCtlVhptpLC.sptaapptCCcoCp....	0	50	86	209
+8520	PF08687	ASD2		Apx/Shroom domain ASD2	Mistry J, Hildebrand JD	anon	manual	Family	This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.67	0.70	-5.06	14	259	2009-01-15 18:05:59	2006-04-20 13:14:24	6	9	75	2	149	229	0	247.60	41	24.19	CHANGED	cELs.....pplsstDcShs....shLsP.....csshsLhcuLhshsp.hht.t.tttthh.phs....................s...sossssahssuss+AE.Lh.chpshp......pt.spsE.spslstKKhELlppls+KLpsL+ctpcsLhp-hpsNssLGp...............................-lEutVpphCKPNEh-KF+hFlGDL-KVVsLLLSLSGRLARVEsALsslspsss.-E+toLhEK....+clLpcQpEDAKELKEpl-RRE+sVhclLuphLstEpLtDYp.......................................HFV+MKuALllEQRcL-DKI+LuEEQLcsLp-SL	..........................................................................................Ls.....ppl...D..h.....sh..ss....csshslhpslhs.s..hh....t...ttth..p..........................................................hsssssaassSssKA.E......Lh.ch.p-h...............tt.stp-.......st..-l.stK...K.......ELlp.uls+KLpsLc-tpcsLhp-hpsNssLGp...............................-VEAhlppl..C+PsEh-Ka+hFlGDL-KVVsLLLSLSGRLARVENAL.....ssl.s....ps.....u.....s...p.E..+ps.LhcK.................pclLhpQhEDA+ELKEslDRRE+hVhslLupaLstEpLtDYp.......................................HFV+MKuuLllEQRcL--KI+LG-EQLcsLh-SL.......................	0	20	30	74
+8521	PF08688	ASD1		Apx/Shroom domain ASD1	Mistry J, Hildebrand JD	anon	manual	Family	This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.  ASD1 has been implicated directly in F-actin binding.	25.00	25.00	36.10	26.00	23.30	22.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.19	0.71	-4.50	8	137	2009-01-15 18:05:59	2006-04-20 13:15:24	5	8	37	0	75	108	0	156.60	34	12.14	CHANGED	A+LQKS+STssLss.-uEsEssssph+st.....u.sos-uSFssTYK-+LKEAQuRVL+ATSF+RRDL-P.hPtp.h.t..cp.shphs.p.s.su.sspsshs.p...tt..ptso.....................sssusPpVsRIGGRKRhTsEQKh+SYSEPEKlNEVG............lpcEhs.t......spp.pposGohADRhKaFEcsuK	...............................pL.+SpSshtL.s...tsptp.....t.................s..s..-s.s.h.s.psY+spLK-AQuRV...LcATSF+.R..+DLc......Ps...t....hst...tp...shth...hp.s.s..........s.sps...........................t.st.......................tsts...ssRhGuR+RhTsEQKh+SYSEPEKhscVG............lst.t.p......................s.sohAcRh+hFEppsp............................	0	3	11	26
+8522	PF08689	Med5		Mediator complex subunit Med5	Mistry J, Wood V	anon	manual	Family	The mediator complex is required for the expression of nearly all RNA pol II dependent genes in Saccharomyces cerevisiae.  Deletion of the MED5 gene leads to increased transcription of nuclear genes encoding components of the oxidative phosphorylation machinery, and decreased transcription of mitochondrial genes encoding components of the same machinery [1]. There is no orthologue from pombe, and this subunit appears to be fungal specific [2].	19.20	19.20	23.30	23.10	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	989	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.92	0.70	-13.80	0.70	-6.87	19	144	2009-01-15 18:05:59	2006-04-20 13:29:25	5	4	120	0	112	159	3	740.80	21	85.92	CHANGED	M..........tustphpshlppCht++lsuspFhsLh...h.c+hPhsttshhphh...hpsp.tp.......................................t.ph-sl.ls.YlstLhh..hl.ssslLpshL...........................sphtp.sppphhh...phohht-.+lhpclhhshhpsphscsltpulthhs......slsphlptllsht.shp.s..st.tshhsp.-tsshh.s..hshllsslhtpphuhplLop...pts...h.tp...uhlshsspsuls...t..p+htthpp.p..hshhsps.spshssshhcshhsphhph...psplhshsshpocutLahYlssh..lsupsh.s...h..............hhp-LIpAuFcshusuh.......hps-sshshaha+sFlls+LPhhlhtht.........ssshsp...sh-.slp+Aluphpsst.sohophhsh...ssoshsDlRp-FlhuhthptLlP.osI.......pplhscs..s.psLslss.hshc-llpphpss.c+.........................hpQllspl-shpust.ssIssAIsElhpchsppp-h.pLpplsstLspps.puLsllLhFps..PpplLp.sL..sphL..........ss.t.hDE..DptE.QsVYppFGslLLLllshpa+Y.....clshhDl........uIsus.pS......FlhcLhttuspSpp.splsppppppLssWlpuLF.sp..GlSD-lMsu..ssPp-hYhLlPhlFpQslhAspsGtl.-hpsLpuGhEYhlpPFLlsuLlhhlhWLtpa.hhcppss.shslphhptllp.....sushSspu..ptlHpsVLpIsupsL.ppL+sh+stpsspp........t..cPhlcsl.spLsh.hs................sshpppcLp.hphh.................sh..psls.hho....s...phssssYsac.llssIchlusp+lLtsllcEL.......+hpsp......sususlslDlusshlsus.s...-shsh..t.hps....s....s....s..............p..hsh+sslph-c-.s.hhs-sDshtu...................u....p......................htshhpphp.t..sshsshstt.....hchctt.s..tsutpsss.............pchsslpp	...............................................................................................................h.thh.psh.pphss..F.th....h.tp.s.......p.h.....ht.p..t.............................................h.h..Yl..l............phl.shh.....................................................................................tp.............s.....hh..phhh...ptph.p.....h..h..........................h.thh..hhth........t..............t...t.p.h....h.t...............hh..h.th..pth.....th.t.......................t......t...hh..t..t........................h.p...................t.t.hp.h.....phh...t....p..l..ph.......h..s.....shl.ha.s...h..h.tps..t..................................h.-LI.ssFsshuphh........ppp.s...h.hhh.Flhp+lP.hh.th...................sh-.pl.pAlt.....ph...sp...h..........sshsp......................s......ss....slRp-FhhuhhhhtL...s.l..............phl.sp...s.pt.s.tt...hpphltph.t..pp.............................h.plltp.h-ph.tsst..ttlstslhphhtphhpphph.pltplst.L..p..p...slshhLha.p..s.tllpsLhthl............................s..s.t.........h-p..sp................h-.pshappFG.llLhllshh.pa..........sls..cl.................hhts..ps........l.hchhttsp....spt.ppltppp.pp.lssWlpuLF........tp........GloD-hhpu..ssspphhhLlshlapQslhAhp...tGhl.p.p.sLpsGhEY................hhpshLhs..sll.sl.......haLtp......hh....pp.p...p.p..lphh..hlh........ss.o.pt.......pthhpsVLplsu..L.p.L+t.hphp..tp..................t...s.hpsl...h...hp...................s..p..tplt.ht...........................................hh..p..sl..h......p......s...Yshc.hhthlph.ss.phl..llcpl............th.sp............stpsphshshhh..hlsh..h....th.........ht.........................................................................t...p.c..h..ptc...hh.ct.p..ht.................................................................................................................................................t..........................................................................................................................	0	28	61	96
+8523	PF08690	GET2		GET complex subunit GET2	Mistry J, Wood V	anon	manual	Family	This family corresponds to the GET complex subunit GET2.  The GET complex is involved in the retrieval of ER resident proteins from the Golgi [1].	20.10	20.10	20.20	20.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.90	0.70	-5.17	9	97	2009-09-11 07:52:02	2006-04-20 13:35:14	5	2	96	4	72	96	0	248.30	21	81.04	CHANGED	pLS-sEKR+LLRERRQtKhSpGsASuRLNcIhuQupusphso....pSVLDpcsssssssspssps............................ssPElpDl.pshsss.............pspsstpslD...chFpplhphQstG....tssss-sshsslhsMhpphts.................s.stostusppst..hhpppLlcYppYphphhKhhhlll+ashhLhsalYahhp.ss.h..h....hhhptL.p.h.sspsFFolFsThEllhluhYYplhpplphhssssshp.ssKllshsSMV....LP.ltshcshVlhhLpYa-lluMhlsDlshVlVhhGLhoh	.............tEpt..RLhRERRpAKh.ppGsASuRLsKITu..u....tssptss.......pSsh-ss.s.sss.s........ss.s.s...sspp................................ssPc.p-..p..t.h..s...........................................t..tptsspshss.p...chhptlht......p...t.t.......................t.........s.ss............t..s...sshs....p....h.....h.p.hh.sh...ss.s..........................s..........................................p.........hh..h.....h....h.h....h...hh...hh.........................................................h.hh.s.Eh............................................................................................................................................................................................................................................................................	1	10	35	62
+8524	PF08691	Nse5		DNA repair proteins Nse5 and Nse6	Mistry J, Wood V	anon	manual	Family	Nse5 and Nse6 are non essential nuclear proteins that are critical for chromosome segregation in fission yeast [1].  Nse5 forms a dimer with Nse6 and facilitates DNA repair as part of the Smc5-Smc6 holocomplex.	25.00	25.00	44.10	30.90	19.20	21.00	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.73	0.70	-5.98	16	54	2009-01-15 18:05:59	2006-04-20 13:39:35	5	2	28	0	31	46	0	438.90	23	94.46	CHANGED	Msusspsp...s.sp.s............hhVp.spcc..s.Ethsuhp.htshspllh.h-t...........t...h......t-llhhhhohssh.ssa.csshlcc.t.hs.st......t.hsppsht.lpphhptLpphcspphsp.slphh+sphhhh.cp.......phchphspphcsptspphhchhhpsst.sp.psh.hlshcsshpshhsh.t.t.thhtsh.hshhhpp.st.hp.h..sLsshl..h..tppssshhhph..tp....hhchlhslhsl....+phhhh.scsstt.pp............lhtFlphltshphhpshspph..hhsshpph.t..hthphhslYhph.-hshs.hahphs+hhsphKtt...............lLppl.pshph....h..sphlhp.hcslhsppchpphhtFh.....................................hlhshssp.hsh..hp.plhphlcs............................phlDhstpss.pch.lsl.p..hh.........................................................................LKshhp	...................................................................................................Mss.........ts..st........p.....h.Vt.h.cc..s.Ehlps.hh.-s.sp.L...Ep.........t.pthhh.s.....sllhhhhh.p...pph.pps..ct.s.hshph.........p.hshts...h..pphhshlpchps.phphh-..hhppphhls.sol......pschppt.thp.tphsct.hslhh+pshSsc.cs.phhohps.Ycphhsh..pcpshh.t.hhhshphspssEFlphhh....oLos.L......p-pss.hh.s.......pch..shh-.Lhslasl....+.hhah.p-ssp.s.spph..........LtsFhp.l.sRphhsthpp.h..hhps..ph...s.p.........sphhssYhp..-ps.hhhah.hh+h.P.hcst...............LLt+l.sscphhp.p.h..pp.lhp.hppLhshpshpphhhFh...................................................lp.hust.hsF............ps.plhphhcs............................shh-.sspss.pcs...lsI...................................................h......................................	0	4	14	29
+8525	PF08692	Pet20		Mitochondrial protein Pet20	Mistry J, Wood V	anon	manual	Family	Pet20 is a mitochondrial protein which is thought to play a role in the correct assembly/maintenance of mitochondrial components [1].	21.40	21.40	21.60	22.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.95	0.71	-4.23	6	105	2009-01-15 18:05:59	2006-04-20 13:51:08	5	3	29	0	59	83	0	97.30	28	44.10	CHANGED	KKtspDappLPRVPoTpaLctc-hosDlLYSGYRPlhhss+-sPLhpppps+.hcathchp..........chsEPhpP....................................WsSSAhGhEaasEW-NVPs-llKcLKPFcssp.pc	......................lP+VsoTpal.tp-hppphLauGYRPlh......h....ss...pt...............tp.....ptpp.....hph........................t..................................................................................W.sS..G.h.a.s...ac.lP..hhtphKPFc......t................................	0	6	23	50
+8526	PF08693	SKG6		Transmembrane alpha-helix domain	Mistry J, Coggill P	anon	manual, Wood V	Domain	SKG6/Axl2 are membrane proteins that show polarised intracellular localisation [1]. SKG6_Tmem is the highly conserved transmembrane alpha-helical domain of SKG6 and Axl2 proteins [1], [2]. The full-length fungal protein has a negative regulatory function in cytokinesis [3].	42.00	42.00	43.00	42.20	41.90	41.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.96	0.72	-4.64	13	66	2009-09-11 17:06:57	2006-04-20 13:56:40	5	4	37	0	39	61	0	38.70	41	5.65	CHANGED	Ksoc..tspsssluluVslPVuVIllVLhhhLhhhaRRpK	.......os.tpssuVslAluVulPlGVIlllLhshLhhhaRRsK..	0	8	20	33
+8527	PF08694	UFC1	DUF1782; 	Ubiquitin-fold modifier-conjugating enzyme 1	Mistry J, Bateman A	anon	pdb_1ywz	Domain	Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1 is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family represents the E2-like enzyme.	25.00	25.00	74.30	44.60	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.07	0.71	-4.76	9	167	2012-10-02 15:28:41	2006-04-20 14:03:43	6	2	145	10	111	163	2	153.40	68	93.63	CHANGED	tsT+polspIPLLpTpAGPRDt.-tWlpRLKEEYtuLI+YVEpNKpsDNDWF+lE.SNcpGT+WhGKCWYlHNhhKYEFDlpF-IPlTYPsosPEIslPELDGKTsKMYRGGKICLTsHFtPLWu+NsPKFGIAHALALG.....................LuPWLAsEIPsLl-pGllK.p-c	...........p.sT+cslupIPLLpT+AGPRDt.-hWsQRLKEEYpuLIp...YVcsNKpuDNDWFRLE.SNcEGTRWaGKCWYlHsLlKYEFDlEFDIPlTYPsTAPEIAlPELDGKTAKMYRGGKICLTsHFKPLWARNVP+FGIAHAhALG.....................LuPWLAlEIP-Llp+GllpaK-................	0	49	65	89
+8528	PF08695	Coa1	DUF1783;	Cytochrome oxidase complex assembly protein 1	Mistry J, Wood V	anon	manual	Family	Coa1 is an inner mitochondrial membrane protein that associates with Shy1 and is required for cytochrome oxidase complex IV assembly. It contains a conserved hydrophobic segment (amino acids 74-92) with the potential to form a membrane-spanning helix. The N-terminus of Coa1 is rich in positively charged amino acids and could form an amphipathic alpha helix, characteristic of a mitochondrial presequence. A cleavage site for the mitochondrial processing peptidase is predicted adjacent to the presequence. Upon in vitro import into mitochondria, Coa1 is processed to a mature form, indicating that it possesses a cleavable presequence [1]. The eukaryotic cytochrome oxidase complex consists of 12-13 subunits, with three mitochondrial encoded subunits, Cox1-Cox3, forming the core enzyme. Translation of the Cox1 transcript requires the two promoters, Pet309 and Mss51, and the latter has an additional role in translational elongation. Coa1 is necessary for linking the activity of Mss51 to Cox1 insertion into the assembly complex [2].	21.10	21.10	21.10	21.10	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.31	0.71	-4.59	43	323	2012-10-01 19:51:31	2006-04-20 14:04:22	5	3	276	0	200	455	12	113.00	22	61.06	CHANGED	hhhh.shaslshssuhhhlhNhpKppSsllsssLatlRpSspsp-hLG..-tIshpsth.....PWlpGplNpl...pGclc.lsFsV+Gs+...u.pGpl+lpusRcsctt.Fplccaslpsc....supp...lcLlc	..............................................hh..h..lhhhshs.s.hhhhh....hs.h...p.......h....pp....o.....s....h..h.ppslhtl+psspshphL....G..-.....s.hppth...............hls.G.phNps.........pG..c..hs..lphsVpG..s+..................u..pGplhhpup.Rps.p.p....aphpphtlphc....psp.l.l...........................................	0	61	111	165
+8529	PF08696	Dna2		DNA replication factor Dna2	Mistry J, Wood V	anon	Pfam-B_8878 (release 19.0)	Family	Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, ( 5'-flap endonuclease) and helicase activities.  It is required for Okazaki fragment processing and is involved in DNA repair pathways [1].	20.70	20.70	20.80	20.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.14	0.70	-5.02	31	301	2012-10-11 20:44:44	2006-04-20 14:14:05	6	24	251	0	216	318	21	196.90	29	17.42	CHANGED	llhhpcsssppptlhL+ssWhpss.hphGDhlHllu.........phssssshslsssps..hlIlpPDhLlSuTslusSlpC.R+uVLp-ph.ptssssohshlhGTIlHElFQcul.....pssphssphlp.phhppslc..pah.plahlshs.hspltpclpp.thsslppWsppahpppsssp.h..............tpsppttlslscllDIEEsIWSPpaGLKGpIDATlcsp	.................................h.....ppttppphshLpstWh...pss..hp.Gshlclhu......................................phs...sp.sp.hl.lsp...sp..s........hlIlp..PDhLlSuTslusShp...C.R+uVLp-ph...+s.............s......sp......ss.....t.shlhGollHEl...FQcul.........................sp....p..h.s...phlp...phhpphlp.......phlpplYt...l......shs..s-s.ppcltp.hhsslppWsppahpppsp.sp.h.................................tpspp.phplscllDlEEplWSPhaGLKGpIDsTlps................................................................................	0	73	117	180
+8531	PF08698	Fcf2	DUF1784; 	Fcf2 pre-rRNA processing	Mistry J, Wood V	anon	Pfam-B_13623 (release 19.0)	Family	This is a family of eukaryotic nucleolar proteins that are involved in pre-rRNA processing [1].	20.90	20.90	22.20	26.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.25	0.72	-3.98	24	326	2009-01-15 18:05:59	2006-04-20 14:20:19	6	6	281	0	231	325	5	97.50	39	31.77	CHANGED	KppccsssspWFsh.cs-..lTsEl++DLpll+hRsslsPc+aaK+sctcp...hPcaFphG.......Tllpsss-a.........au.oRh............s++cRppohl-E...Llp-sshpca.....h++K	...................pppcosGssWFshsts-..lTsElK+DLplL+hRs.slDPK.RaYKK..sctct.....hP+aFQlG.......Tll-uss-F....................as.uRl............s+KpRKp..Tll-E...Llu.Dpchppa..++K...................................................	0	82	129	195
+8532	PF08699	DUF1785		Domain of unknown function (DUF1785)	Mistry J, Wood V	anon	Pfam-B_1585 (release 19.0)	Domain	This region is found in argonaute [1] proteins and often co-occurs with Pfam:PF02179 and Pfam:PF02171.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.47	0.72	-4.60	46	958	2009-09-11 17:06:15	2006-04-20 14:26:01	5	11	239	8	597	914	1	53.60	41	6.15	CHANGED	hslupSF.Fstp...........hsp.......sLGs.Glpuh+GaapSlR.........so.....ptu.LhLNlDVSsssFhcs	...............................................sVGRSF..Foss.............................tst......tsL..Gu...G..hEsWh........GFaQSlR.........Pu.......pht..hhLNI.D........VSsTAFacs........................	0	155	301	462
+8533	PF08700	Vps51		Vps51/Vps67	Mistry J, Wood V	anon	manual	Family	This family includes a presumed domain found in a number of components of vesicular transport.  The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi .  Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1 [1].  Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues [2].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.70	0.72	-4.14	56	831	2012-10-03 17:31:52	2006-04-20 14:27:19	6	16	297	0	605	1053	2	83.80	20	11.90	CHANGED	hsssshcscphhp.t.htpps.....l....pplhphcpplp........pplpphpp-l+phVhpsYpchlpss-sIpphcsph........pplpsplsplppshpphspt	..............................thsspthh.........p..t.ht.p.ps.....................h....pclp.phc.pplp...................................pphcppsp-l+phVhc..........sYpchIp......su.......cpIp.p.hcsph............pplps.lsphppthtth...t...................................................	0	197	331	497
+8534	PF08701	GN3L_Grn1		GNL3L/Grn1 putative GTPase	Mistry J, Wood V	anon	Pfam-B_22650 (release 19.0)	Family	Grn1 (yeast) and GNL3L (human) are putative GTPases which are required for growth and play a role in processing of nucleolar pre-rRNA [1].  This family contains a potential nuclear localisation signal.	21.20	21.20	21.40	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.09	0.72	-4.08	36	317	2009-01-15 18:05:59	2006-04-20 14:33:43	6	5	270	0	228	328	2	78.00	37	14.88	CHANGED	+hRaKIcKKsut+pRKt+KtAK..Kssph+S.+p.p.K..DPGIPNsaPaK-clLpElEcc+pppcEc+ppp+tppptc+pttp.cps	...................+hRaKIpKKstt+pRK.RKt....A..K...Ks.sp..........h.....+p..+t..+.K.......DPGIPNtaPaK-clLcElE...pc+pptc..Eccppp+ptpppppptt...tt................	0	78	127	190
+8535	PF08702	Fib_alpha		Fibrinogen alpha/beta chain family	Mistry J	anon	pdb_1m1j & pdb_2a45	Domain	Fibrinogen is a protein involved in platelet aggregation and is essential for the coagulation of blood.  This domain forms part of the central coiled coiled region of the protein which is formed from two sets of three non-identical chains (alpha, beta and gamma).	29.50	29.50	29.50	33.20	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.15	0.71	-4.07	20	256	2009-01-15 18:05:59	2006-04-20 14:42:43	5	5	86	240	81	298	0	130.80	29	29.67	CHANGED	scpssstpsD-caGshCPTsCclpshLs+hcpslc.pclpplcshLpphpppsssscphlpplpshhpscpssspssptlhsthpcslccpl..hhhh-pplssp.ppIchLQsslpsppp+Ip+LEscIspthcpC+pPCpcos..pIss	..........pts.shh.DpcaGshCPTsCtltshLsphppslc.pclppLcs.Lpphpppospspphhptlpphhpsctts.psst..sl....st.....hpps.+chh...hhhcth..ph.pplphLpphlps...chppLc.cls...p.CptsCppss..pl..s............	0	3	9	33
+8536	PF08703	PLC-beta_C		PLC-beta C terminal	Mistry J	anon	pdb_1jad	Domain	This domain corresponds to the alpha helical C terminal domain of phospholipase C beta.	23.10	23.10	23.60	23.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.23	0.71	-4.58	8	215	2009-01-15 18:05:59	2006-04-20 14:48:55	5	16	68	2	101	201	0	168.00	38	15.68	CHANGED	hDp-....l.-h+-cppQcLLpLREEQacsp++pKcpHlppthpKLpElAcEpQssQLK+LKElsE+EKKELKKpLD+KRh-+Is..pA+Tp-KttpEc-KpEIN+SHIQEVVQsIKpLEEsQp+RQEKLpEpps-sLQpIp-cEPphQuphht-aptch+pLPsEVpchLppptpcs...........shPstscs	.......................................p+hh-L+-+QpQpLL.pLRpEQh.sEttp+ccH......lcphhpKLp-lAcEsQs..sQL.K+LK.EhsE.+Ep.KELpK...pl-cKRppc...Ip......pspo+DKpp.tE.c.KpEl.s+SaIpEsVph.I+.RLcEspp+RpE+L.cpppplhQQIt-c.cs.c....hpt.ph.....tEh.ptphttL....-l...h......................t......................	0	10	19	51
+8537	PF08704	GCD14		tRNA methyltransferase complex GCD14 subunit	Mistry J, Wood V	anon	Pfam-B_5615 (release 19.0)	Family	GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.52	0.70	-4.88	7	1145	2012-10-10 17:06:42	2006-04-21 14:09:47	5	11	975	20	564	2188	468	194.50	31	60.23	CHANGED	GalYlLtPTPELWTlsLPHRTQILYosDIuhIhhhLEl+PGoVVsESGTGSGSlSHuIhRolAPTGHLaThEFHppRAcpAR-EFccHtl...sp.hVTVpppDVC.ppGF...tlsthADAVFLDlPuPW-AlsHAhssl.+hcGGRhCSFSPCIEQVQRTCpsLtphGFsEIpTlEVL.psasVRpsplsh.DL.utst.cssp..................ssssss..pSus.................Ph.....................pEshGHTGYLTFAsh	....................................................................sh..shP+t.sQl.lY.sKDh.u.......I.l.h...h.h.-..l.h..P.G.s.p...........VlEAGsGSGuLohsLhRA.l..................u.....s............p........G.p..lho.aE....h...+p..-..ht....ch.A............p...p...s....h........c......p....h...t.h.................sp....h..pl...p...h...p....D.....l..t.....p.......p.......u.h.......................................................t...t...............s............h........D.....t........l..h.....L.....D....h....s..P..W..p...s...l..p...p.st........c.....s.............L...................hs...........G.......G.............h..l.ss.a.s.....s...sl......p.Q..l.......p.......+s.......hc..sL..+..p...t...s...a...s...........-.......p.shEs...hh.Rpac.s.....p.....................................................................................................................................................................................................................................................................................................................................hh...............................................................................................	0	193	343	476
+8538	PF08705	Gag_p6		Gag protein p6	Mistry J	anon	pdb_2c55	Domain	HIV protein p6 contains two late-budding domains (L domains) which are short sequence motifs essential for viral particle release.  p6 interacts with the endosomal sorting complex and represents a docking site for several cellular and binding factors [1].  The PTAP motif interacts with the cellular budding factor TSG101 [1].  This domain is also found in some chimpanzee immunodeficiency virus (SIV-cpz) proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-8.16	0.72	-3.92	130	21799	2009-01-15 18:05:59	2006-04-24 12:03:20	6	32	62	6	0	17390	0	35.10	70	10.25	CHANGED	.QSRs.......E.....PT...APP.A............Esat.hGEE....h.sss...K.....QEt+....D.........+.........PL	.............LQS.RP..........E.......PT......A..P.P..A........E.S..F.R..FGEE........h..TPu........K............QE...h........D..............+.E........PL.................	0	0	0	0
+8539	PF08706	D5_N		D5 N terminal like	Mistry J	anon	manual	Domain	This domain is found in D5 proteins of DNA viruses and bacteriophage P4 DNA primases phages.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.96	0.71	-4.12	74	1334	2009-09-10 21:39:52	2006-04-24 16:40:24	6	39	1034	0	232	1230	422	157.50	16	23.13	CHANGED	Aphhtcha.....tpp..ltasstht...............Whh.asuh.........Wp.s............ppthtphhppht.....chhhtpt..............................................................th.phhhpttpspthpshlpphpt......................................hssphpchDsc..shhlshsNGll..Dlcs..Gph....................ts..tcs.cchhTp.....hhshsa....................ps.......................ssst.........appaLpc...hhs	..............................................................................................................................................................................................................................................................................t...............h...a.s..................Wt..................h.t..hh.tphh.......t..h.tth....................................................................................t.h.....t.h..s...pptlp.s..slcthp...........................................h.ht.pph...c.ss......pLlshp.N.G.ll......Dlco......uph...........................................................ps.....ass..cp..hhop....hssssa.............................................ss........................................s.....pssp...........apcaLpph...............................................................	0	80	154	199
+8540	PF08707	PriCT_2		Primase C terminal 2 (PriCT-2)   	Mistry J	anon	Aravind	Domain	This alpha helical domain is found at the C terminal of primases.	20.90	20.90	21.00	20.90	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.87	0.72	-4.11	50	419	2009-01-15 18:05:59	2006-04-24 16:58:30	6	30	316	0	84	430	307	76.60	23	10.50	CHANGED	clcshLphlss...s.h.DYcsWlplGhAL+pth.....u........spuhclWcpWSpp........us+Ycs.pc..spppWpoF.....csss...lThuTlhhhA	...................htthlphlss....s.h.sYppWlplG..hAlpsth......u.........cpuhphapcaSpp........us..+Ypt...pc.....scphW..psh........psss........lshuTlaahA...........	0	26	56	72
+8541	PF08708	PriCT_1		Primase C terminal 1 (PriCT-1)	Mistry J	anon	Aravind	Domain	This alpha helical domain is found at the C terminal of primases.	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.29	0.72	-4.16	93	1023	2009-01-15 18:05:59	2006-04-24 17:24:04	6	23	745	0	118	843	165	69.20	23	18.39	CHANGED	pttht..stssthGRNssLFchs.tthh.hctlsppt..................lhphspthNsp.h......ssPLstpElcpss+Slh+hphp	.................h....httsptuRNssLhphs...tthh.hptlspph.................shphhth.hNsh.h.......ssPLs.tpElpph.hcShh+hph..........	0	47	77	105
+8542	PF08709	Ins145_P3_rec		Inositol 1,4,5-trisphosphate/ryanodine receptor	Mistry J	anon	pdb_1xzz	Domain	This domain corresponds to the ligand binding region on inositol 1,4,5-trisphosphate receptor, and the N terminal region of the ryanodine receptor.  Both receptors are involved in Ca2+ release. They can couple to the activation of neurotransmitter-gated receptors and voltage-gated Ca2+ channels on the plasma membrane, thus allowing the endoplasmic reticulum discriminate between different types of neuronal activity [1].	20.30	20.30	20.30	20.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.15	0.70	-11.37	0.70	-5.31	19	714	2012-10-02 19:42:32	2006-04-25 13:25:41	6	68	123	27	374	627	9	196.90	40	6.46	CHANGED	ppsSFL+hGDlVSLYsEuosp.........GalSThGLs--+CllpssusshssP...Ph.cFcsClFpl.sPhsphsApcphhput.scpssss..-........tuAphpp+ps........t..lhYGpslQ.LLHh+SshYLos.pphPuhh-KsAh+VsLspsus.Eu..sWahIpPhaKhRStGDsVsVGDcVlLssVsus.......p..LH.uss.thh-ssst.hpVsussppTsWplphahpts-s	.......................................................................................p...t.Lp.h.sD.lsL.s.u.shp................hhlu.s.....G.h.s............s..ch..C..h.lpsts.....ss.psP.......................P...chp....ChFhl.p.h...p....hpA........p.......ph...hp...s..t..s...c...tss..pt..t......................................................puAphtt+ps.............................................................lhY.G.p.s.I...Lh.HhpSsh......YLos.pp........uhh-...K.A..hc....VsL.......ppsus......................Eu....sWahIp.P..h......K...R.....S.p.G.....-..p...........V....hl.GDcllL.ss.V...su.t.................p..LH.u.................hss...s...s...........h.......pV......s......u..s..p.p......T.Wpls.hhphp....................................................................	0	133	156	257
+8543	PF08710	nsp9		nsp9 replicase	Mistry J	anon	pdb_1uw7	Domain	nsp9 is a single-stranded RNA-binding viral protein likely to be involved in RNA synthesis [2].  Its structure comprises of a single beta barrel [1].	22.10	22.10	22.70	41.20	19.90	22.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.35	0.72	-3.91	9	698	2009-01-15 18:05:59	2006-04-25 14:22:47	5	34	208	10	0	632	0	103.80	56	2.26	CHANGED	NNElhPspLKppsspAusD.ssssss.upAhYNstsGppalhAhlSspssLKasKaEpcsG..hlslEL-PPC+Fhl-sPpGPplKYLYFVKsLNsLpRGtVLGhIuATVRLQ	.............NNElhPstL+ppustAuss.ssssss.upsaYsspsGtphlhAllSspssLKas+a.pssG..hIhlEL-PPC+FsscsspG.P.cVKYLYFlKsLNoLpRGhVLGtIuATVRLQ	0	0	0	0
+8544	PF08711	Med26	TFIIS;	TFIIS helical bundle-like domain	Mistry J, Moxon SJ, Bateman A	anon	pdb_1wjt & Pfam-B_7936 (release 8.0)	Domain	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex [4]. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5 [5,6].	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.24	0.72	-4.46	76	1525	2009-01-15 18:05:59	2006-04-25 14:52:23	6	42	326	13	982	1411	10	52.80	30	10.64	CHANGED	clLptLpp..hs.ho......t-hLppTclGhsVstl+Kp............ssppltplAcpLlpc..W+chlp	........................lLptLpp....hs.lo................h-hL.p....p.T.p.lG+sVs.tl+Kp....................pspcl....pphA+pLlpp..W+chl...............	0	274	473	734
+8545	PF08712	Nfu_N		Scaffold protein Nfu/NifU N terminal	Mistry J	anon	pdb_2ffm	Domain	This domain is found at the N terminus of NifU and NifU related proteins, and in the human Nfu protein.  Both of these proteins are thought to be involved in the the assembly of iron-sulphur clusters [1][2].	21.30	21.30	21.40	21.80	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.37	107	1440	2009-01-15 18:05:59	2006-04-25 16:01:34	6	14	1107	3	493	1036	1572	85.90	34	36.69	CHANGED	Ip.TEsTPNPssLKFlP.uppllssu..o..h.-FssscpAts....SPLAppLF.plsGVpuVFhGsDFlTVoKsst.s-WsplKPplhuhI.h-ahpuG	.............IphEsTPNPsohKhl.....u..ps...lhspt....o....h-a.h.st....p.pstp.......usL.sppLh..pl.-..GVpuVFashD....FloVsK.......psc...s...-WpplhPplhusl.h-.h........................	0	159	305	413
+8546	PF08713	DNA_alkylation		DNA alkylation repair enzyme	Mistry J	anon	pdb_2b6c	Family	Proteins in this family are predicted to be DNA alkylation repair enzymes.  The structure of a hypothetical protein in this family shows it to adopt a supercoiled alpha helical structure.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.32	0.70	-4.83	89	2486	2012-10-11 20:01:01	2006-04-25 16:53:16	6	10	1475	10	471	1879	159	170.60	17	82.37	CHANGED	lpppLpshus......sppAtthppahK.......pphtalGlpsPth+pls+phhpphsht.........thsppLapssh.+Et+hhAhpllhphh..pc....hs.s................hphhpphlt..phstW-hlDthssplluphlhp..............thtshlhpWspo-shWhRRsAlltplhatcp........schptlhphspthls-p....-.hIpKAlGWhLR-huKp.c.shltpFlpp........ctpt.hsthuhRpAhchl	.....................................................................................................................................p.........t..h....................hhGl.hs.hp.hhcthh.t.................................h.t..hh......t..p....................-.............hh.uh.hh..........t........t.t.............................h..htthh.....ph.s..at.hhD.h....h..hhtth.h.t........................h..phh.pW.h.ts.p.....p...aht.Rh...u...h....h..........h.....h.h.p............tp..t....h..hthltt..h..p.sp..................p....hl.pp.ulu.hLpphutp.p.phhh....phlp..............................................................................................................	0	196	347	408
+8547	PF08714	Fae		Formaldehyde-activating enzyme (Fae)	Mistry J	anon	pdb_1y5y	Family	Formaldehyde-activating enzyme is an enzyme required for energy metabolism and formaldehyde detoxification.  It catalyses the condensation of formaldehyde and tetrahydromethanopterin to methylene tetrahydromethanopterin [1].	20.90	20.90	21.30	23.50	18.40	20.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.62	0.71	-4.54	45	346	2012-10-03 01:04:38	2006-04-25 17:32:49	6	2	176	10	133	327	105	146.40	45	77.97	CHANGED	lGEALlG-Gs.........ElAHIDLlIGs+sGPsGpAFANuLsststGHTsLLAVlpPNLhsKPsTlhlsKVTIKstcQAsphFGPAQuAVA+AVADuVp-GlIPc-ps-DlsllsuV.......FIHPpA........pDcp+IacaNYpATKhAIpRAhpshPshcclltp+cpupHPhhu	..........hGEuhlstus.........phAHIDLlIGs+s..usstpAFANuLsspppGaTsLLAVlsPNLhsKPsTlhhsKVTIKss.cQAsphFGPAQtAVAcAVsDuVt-GlIPt..-cA-DlhIlluV.......FIc.ps.........D.pcl.chNYpAsp.AltpAhtt.PphpplhtttpphtH.h.s.......	1	34	93	115
+8548	PF08715	Viral_protease		Papain like viral protease	Mistry J	anon	pdb_2fe8	Family	This family of viral proteases are similar to the papain protease and are required for proteolytic processing of the replicase polyprotein.  The structure of this protein has shown it adopts a fold similar that of de-ubiquitinating enzymes [1].	21.40	21.40	21.40	23.00	19.60	20.50	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.10	0.70	-5.36	5	760	2012-10-10 12:56:15	2006-04-26 12:01:56	5	34	211	22	0	801	0	290.70	29	6.89	CHANGED	csKslTIalTEDGVNl+oVVVcsucSLGpQFGsVas+sKshptVhPuDssEDKplhhlPosDhlt..uFKsslpYaoLDsptYuhYhssL..spKWph..VsGFplLcWsDNNCWVNSslllLQtuKl+Fpu.uLssAWsKhluGDsssFVAalYAsssusVG-hGDAc-sLo+LuEHhssDusssLL+hsVCspCGhK.osolsGlEAsIh.suolshDshKTGYS.sCsCGpcssscVlpssusalllsAs-s.PuAss+LpsGluhss..FoGSsssGH.YT.apAAscAhY..DGA+hpKaucpossVTAlah+tuhhopslhPVus	.....................................................................................................................ph.lhhT.Dssp......hcs..Vt.s.ohG.ph.G.s.shhcstshpt.hhstst......psc.hh..h..s.....D...........................sh.....c........hh....s....hD..t.p.hh.Yhp..sL...hppaphs.h..s..shhslK.sDNNCalsushlhLQth.c.lpFps.hlp-AWtcapuGcsssFVuhhhA..hsshp.hG-.GDuc.hLppLhphhs.h-.sstlhp.pssspCG.K.ppphpGl-ushh.hts.shpphcpGhp.sCsCGpssspplsphcushlhh..p..s........s.....ss.tp.h..pu..s..shss..a.p..G.shp.sGH.YT..a.st..p..p..s..h..h...Dus....+hpKhsc.ph.lT.s.hhh.h..s.h.........t..................................................................	0	0	0	0
+8549	PF08716	nsp7		nsp7 replicase	Mistry J	anon	pdb_1ysy	Domain	nsp7 (non structural protein 7) has been implicated in viral RNA replication and is predominantly alpha helical in structure [1]. It forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure [2].  The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase [2].	25.00	25.00	25.70	25.20	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.70	0.72	-3.59	7	563	2009-09-11 00:21:17	2006-04-27 12:56:27	5	32	199	10	0	567	0	84.10	55	1.51	CHANGED	SKLTDlKCTsVVLLulLppL+VEuNSKhWAaCVpLHN-ILhssDsscAh-pLluLLusLhShpuslD......LscLs-shh-ssolLQ	..SKLoDVKCTsVVLLslLppL+VESNSKhWuYCVpLHN-ILhscDsscAhEKLluLLssLhSh..puslD...........lscLC--hlcssolLQ.	0	0	0	0
+8550	PF08717	nsp8		nsp8 replicase	Mistry J	anon	pdb_2ahm	Domain	Viral nsp8 (non structural protein 8) forms a hexadecameric supercomplex with nsp7 that adopts a hollow cylinder-like structure [1].  The dimensions of the central channel and positive electrostatic properties of the cylinder imply that it confers processivity on RNA-dependent RNA polymerase [1].	25.00	25.00	29.20	28.20	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.44	0.71	-4.71	9	574	2009-01-15 18:05:59	2006-04-27 13:42:27	5	35	209	6	0	578	0	198.40	54	3.56	CHANGED	uVASpFsslPSYltYEsA+psYEcAlu...NGuus.QllKpL+KAhNlAKStFDR-tuVQ+KL-RMAEQAhTsMYKEARusDRKSKVVSAMpohLFuMLR+LD.sulssIlspARsGVVPLulIPtsuAsKLhlVlPDhssas+hhstssVpYAGslWsIppVpDsDGcsV+lp-lTpp.....Nt.sLsWPLllsspR.....s.VKLQ	....ulsSEFuslPSYstYEpA+psYEcAlu...NGsus.Q.LKpL+KAhNIAKStFDRDtAVQ+KL-+MA-pAhTpMYKEARusD++uKVlSAhpohLFoMLRKLDssuLNsIlspA+sGsVPLshIPhssAsKLhlVlPDhpoaspss-sssVTYAuslWpIppVhDADGp.lpLsEIshs.....ss.NlsWPLllsspR..tsps.stLQ...................	0	0	0	0
+8551	PF08718	GLTP		Glycolipid transfer protein (GLTP)	Mistry J	anon	pdb_1wbe	Domain	GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids [1][2].	25.60	25.60	26.00	25.60	24.90	25.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.63	0.71	-4.17	68	702	2009-01-15 18:05:59	2006-04-27 13:59:54	6	10	261	19	468	642	6	140.30	27	56.28	CHANGED	spl.sptFLcuscplsplhc.........hl...G.ssFuhlppDltuslp.+lcphh..tsspt...............................hpoLpshlptEhpsth.t.tps.................ouocsLLWLp.........R........u.LcFlthhLcplhs........s.spp.....hsssspcAYspoLptaHuall+pshp.........lAhtusP........sRcphhptlssss	............................................................t..l.sp.FLpusptls..hhc.............hl...G...ssFs.lppDlhusl..p.+lcphh....ss.s.tp...............................hpoLpsllptE.hps..thhp..hps..................ouocuLLWLp..........R...................u.LcFlthhLpplhs.......s.ppp..............lpssh.ppAYspo.LptaHuWll+tshp.....................hAh.hshP........pRppFhttls...t........................	0	153	245	359
+8552	PF08719	DUF1768		Domain of unknown function (DUF1768)	Mistry J	anon	pdb_2b3w	Domain	This is a domain of unknown function.  It is alpha helical in structure. The GO annotation for this protein suggests it is involved in nematode larval development and has a positive regulation on growth rate.	31.30	31.30	32.20	31.50	30.50	31.20	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.15	0.71	-4.49	80	1081	2009-09-13 10:17:57	2006-04-27 14:19:58	6	29	789	1	374	820	99	145.10	35	55.13	CHANGED	lhFap.pp......shuhhSNah.ps.h...........pl.....c..........s.......hp...asosEH........Ya.ApKhth....h..p........................................ppp...pIhp..up.....sPtcstp...............LGRp..ht....h+..W.pph+hplMhpushtKFpQ..pt.................c...L+phLLsT....GsphLVEsSshD....phWGsGhs.................................hpGpNhLGclLMcVR.ccLpp	.............................................................................Fat.t.......shushSpahs.t.s..h...............................ph..s........................................................u..............hp.....asosE+....................a..h.....ApKhh..........h...t............................................................tp...p........pIhp....ss........sPhp....stp...................hGRp.....hp..c....hp..W..pph+..pl.h....tcuhhtKFpQ......ps...................................c...L+phL..LuT....................u....st...hL....V....E.s....o......pD..............thWGsGhs.................................................hpGpNhLGhhLMclRcpL..t..................................................	0	172	262	347
+8553	PF08720	Hema_stalk	FluC_stalk; 	Influenza C hemagglutinin stalk	Mistry J	anon	pdb_1flc	Domain	This domain corresponds to the stalk segment of hemagglutinin in influenza C virus.  It forms a coiled coil structure [1].	21.60	21.60	301.20	301.10	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.18	0.71	-4.75	3	144	2009-01-15 18:05:59	2006-04-27 14:57:47	5	1	130	3	0	107	0	172.80	99	27.14	CHANGED	IFGIDDLIIGLLFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQ	IFGIDDLIIGLLFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWIIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQ	0	0	0	0
+8554	PF08721	Tn7_Tnp_TnsA_C	TnsA_C;	TnsA endonuclease C terminal	Mistry J	anon	pdb_1f1z	Domain	The Tn7 transposase is composed of proteins TnsA and TnsB.  DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The C terminal domain of TnsA binds DNA.	22.00	22.00	22.00	22.20	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.45	0.72	-3.97	38	303	2009-01-15 18:05:59	2006-04-27 16:28:33	6	4	250	4	69	203	9	78.00	24	26.68	CHANGED	EI..s.hhhcNlpaLhshhpppsstphpht.p.......lhphlpppss..psltslhpphs.t...........slptupsL..lttLlApchlthDl	...................................-l..sphhhcNIpalpsh.hcp.......ts..p...h...sph.ht.........lltpL..ptpst...sslpplhspl.................slssspulhhlptLlAp+hIpsDl...	0	20	36	51
+8555	PF08722	Tn7_Tnp_TnsA_N	TnsA_N;	TnsA endonuclease N terminal	Mistry J	anon	pdb_1f1z	Domain	The Tn7 transposase is composed of proteins TnsA and TnsB.  DNA breakage at the 5' end of the transposon is carried out by TnsA, and breakage and joining at the 3' end is carried out by TnsB. The N terminal domain of TnsA is catalytic.	25.50	25.50	25.50	25.50	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-10.10	0.72	-3.99	76	557	2012-10-11 20:44:44	2006-04-27 16:37:50	6	8	444	4	111	422	696	88.40	25	30.37	CHANGED	ssVhchc-Q.Pl.......................shphshp.Ghp+s.................hTsDaLlphpss.........t.hhhplK.........ppcLp....c....p+hhcKhph..........p+.pahpp.pGhsatlhTE	...................................sVh-lp-Q.Pl.........................shphs..pp.shp+...................hosDFLlshpss..........phhhlpVKs......................sp.clp................c........pchhpKhch......................t+.tahpt.ps.hpatlhs.....................................	0	23	62	83
+8556	PF08723	Gag_p15		Gag protein p15	Mistry J	anon	pdb_1hek	Domain	Gag p15 is a viral membrane-binding matrix protein which is alpha helical in structure.	26.10	26.10	26.10	26.60	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.72	0.71	-4.12	2	200	2009-09-11 06:11:00	2006-04-27 16:54:40	5	3	5	2	0	160	0	109.70	81	35.42	CHANGED	GDsLTWSKALKKLEKVTVQGSQKLTTGNCNWALSLVDLaHDTsFVKEKDWQL+DlIPLL-DVsQoLSGQE+EAFE+TWWAIoAVKMGLQINNVsDGKASaQLLRAKa.....sKKQuEssEtY	.....GDsLTWSKALKKLEKVTVQ.GSQKLToGNCNWALSLVD.LFHDTNFVKEKDW...QLRDVIPL...LEDVo.QT....L.S.G.QE+EAFE+TWWAIsAVKMGLQINsVsDGKAoaQLL.+AKaE+.+.su.s..KKQuEPpEEY......	0	0	0	0
+8557	PF08724	Rep_N		Rep protein catalytic domain like	Mistry J	anon	pdb_1m55	Domain	Adeno-associated virus (AAV) Replication (Rep) protein is essential for viral replication and integration.  The catalytic domain has DNA binding and endonuclease activity.	21.30	21.30	21.60	24.30	20.00	21.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.15	0.71	-4.75	9	213	2009-01-15 18:05:59	2006-04-27 17:04:03	5	2	57	9	0	219	0	158.90	41	26.63	CHANGED	hacsllp...........lSsNFlsasssphWp....uhhsL-ps-hPp...LTss-+lhshalschsshhcsPsu.....caFlQhEps..-phFHlHlllussslsshsl...ssplcsths+slachspPplsshFtsshoKK...Gt.phsu.saIssYLhPKl.Ppl.WuhTNlpEYthsC.sLphR+phhcpa	.....................................................................................................t.........lphsptlht.hLpphsph.p..tuP.......haFhQlEssp...EctaHlHlVlstssls.sRsl...hsp.lcshhs.phhhphhs.sh.lha..shTpp....G+haps...sppFI.NYLh.Kl..P..l.p.............ll.W.shTNID.t.ahssslSsshR+thhpt.h....	0	0	0	0
+8558	PF08725	Integrin_b_cyt		Integrin beta cytoplasmic domain	Mistry J	anon	pdb_1m8O	Domain	Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion.  Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit.  Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity.  This domain corresponds to the cytoplasmic domain of the beta subunit.	21.30	21.30	21.30	21.70	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.22	0.72	-4.57	33	606	2009-01-15 18:05:59	2006-04-28 13:40:02	6	34	134	25	288	512	1	45.40	48	6.09	CHANGED	KlLhplpD+REat+FE+E+tpu+WspucNPLY+sAToTap.NPsYtup	.......KLLhpIHDRREaAKFEcE+t.pA..KWcs.up.NPlYKsAsoThh..Nspapt.........	0	59	81	178
+8559	PF08726	EFhand_Ca_insen	efhand_Ca_insen;	Ca2+ insensitive EF hand	Mistry J	anon	pdb_1h88	Domain	EF hands are helix-loop-helix binding motifs involved in the regulation of many cellular processes.  EF hands usually bind to Ca2+ ions which causes a major conformational change that allows the protein to interact with its designated targets.  This domain corresponds to an EF hand which has partially or entirely lost its calcium-binding properties.  The calcium insensitive EF hand is still able to mediate protein-protein recognition [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.41	0.72	-4.00	23	640	2012-10-02 16:17:27	2006-04-28 13:56:49	5	73	193	3	326	1364	9	67.50	48	5.87	CHANGED	-psouEQlhpuF+tl.AssK.sYlTcp-L+psLsP-ps.-aClppMs.ap.......ssp...pps.su.aDYhuFspsLau	.......................-scTuEQVhsSF+hL..As.s...K..sYITt-ELR...+...p.........LsP...-.QA...-YClpRMsPYp.....................................GPc......usPuA.hDYhuFosuLat.......................................................	0	82	120	210
+8560	PF08727	P3A		Poliovirus 3A protein like	Mistry J	anon	pdb_1ng7	Domain	This domain is found in positive-strand RNA viruses.  The 3A protein is a critical component of the poliovirus replication complex, and is also an inhibitor of host cell ER to Golgi transport.	22.30	22.30	23.00	22.40	20.90	22.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-9.08	0.72	-4.63	21	1219	2009-01-15 18:05:59	2006-04-28 16:12:37	6	15	264	2	0	1300	0	56.90	55	2.66	CHANGED	GP..a+.lpIsl..csPPPsAIsDLLpSVDotEVRcYCccptWIVPt...psslERslNpA	.........GP..a+sl+Isl..psPPPsAIsDLLpSVDSpE.VRcYCc-pGWIlPt..ossplERclNRA....	0	0	0	0
+8561	PF08728	CRT10		CRT10	Mistry J, Wood V	anon	manual	Family	CRT10 is a transcriptional regulator of ribonucleotide reductase (RNR) genes [1].  RNR catalyses the rate limiting step in dNTP synthesis.  Mutations in CRT10 have been shown to enhance hydroxyurea resistance [1].	21.90	21.90	22.00	22.10	19.00	21.80	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.22	0.70	-6.54	9	141	2009-09-13 09:52:06	2006-05-02 12:36:21	5	8	105	0	106	153	0	320.30	15	55.24	CHANGED	hsPtchhhssh-phshpclhhp.ssppapsthplphhu............FKNNlhshhp....tsaLhlussoplhlashDslsshsph................hc..scsshsshhDc.hlSohP..saTINal.phssahGpphLssChDsGhlhhWhhsoIlp.hppa..........ps-.c.............th..psR...hplpPc...hpl+hcu...SsWuhDhh.sa.....sspslIssucNu....puloL..hhachs..c-RaYhtc....shp..............h.HNlPslSFlssp.sst.ha.lhVussoIsGplhohpFp...Fp.pps...............................................h.clphssshh.o+shhu-DsWTlpPlSscsFhpVsuhchlsss.pphpccpplppIhp-StlLss..s.s..os.hGhuAphp.apsPVssl..........................................................................................................................ps+pss...ppps...............................................................................................phpss+.oslc--a................................pplHctlcp.h....ph..tpcpps.G..h...........ps.hlhlTTs++lsLh+scsLhssuuTp.clFsLp..shsptscho....NRIShsphI.ELsChlsuSQ.GLlSlhRLspa+GlYuhRQEaIhs.....................................sspslshshtthpslshltl..............p-psh...h.hhhlYVsYssulh.sYcI	......................................................................................................................h......................................................................................................................................................................ptlN.h.hhs.h.........htp-hlhhshDsG.lhha.hptlht.hpph...................................................ts.....h....ht....SsWulshh........p..phlAsutNp............lsl..ahht.........ppt...........t....................................................................................tNlPslsFhspp........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h......................................................................................................................................................	0	18	54	90
+8562	PF08729	HUN	HPC2; HRD;	HPC2 and ubinuclein domain	Mistry J, Wood V, Balaji S, Iyer LM, Aravind L	anon	manual	Domain	HPC2 (Histone promoter control 2) is required for cell-cycle regulation of histone transcription [1].  It regulates transcription of the histone genes during the S-phase of the cell cycle by repressing transcription at other cell cycle stages. HPC2 mutants display synthetic interactions with FACT complex which allows RNA Pol II to elongate through nucleosomes [2]. Hpc2 is one of the proteins  of one of the multi-subunit complexes that mediate replication- independent nucleosome assembly, along with histone chaperone  proteins. the Hip4 sequence from SCH. pombe is an integral component  of this complex that is required for transcriptional silencing at  multiple loci [3]. HPC2, ubinuclein/yemanuclein, and the cell cycle  regulator FLJ25778 share a conserved domain that is predicted to  bind histone tails [4]. This domain is also referred to as the  HRD or Hpc2-related domain.	26.90	26.90	26.90	27.10	25.20	26.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.12	0.72	-4.10	54	344	2012-10-09 00:06:17	2006-05-02 12:49:19	5	6	246	0	236	333	0	52.80	40	6.69	CHANGED	pp+ccpch.c....tttYDp-DsFIDDoE...hh-Ehh.............hssppsGFalspGsLt.	..................t...tcpc..chhshshtYDpsDsFIDsSE...ha-Ehh.............hssptsG.FalssGsL...................	0	70	121	180
+8563	PF08730	Rad33		Rad33	Mistry J, Wood V	anon	manual	Family	Rad33 is involved in nucleotide excision repair (NER).  NER is the main pathway for repairing DNA lesions induced by UV. Cells deleted for RAD33 display intermediate UV sensitivity that is epistatic with NER [1].	21.70	21.70	23.90	35.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.06	0.71	-4.79	9	47	2009-01-15 18:05:59	2006-05-02 13:22:52	5	2	40	0	30	41	0	135.10	37	77.88	CHANGED	ht.ptpho..........+lPsElEDEILEtYuphot........ppDhsls-LPpaFcsLplPpsa...........Ychl+sc..clpl-uT.............................DIlDh-KLlpssh+LLhFhsN.opIcspWcLhlssuuc..tpshs.h.lpsahLol.DLpKlpsplshDps.	...........ps......p..........cls.ElEDEILEtYup.sh........-pDhslscLPpaFccLpl..sh...........achl+sc..slhl-uo.............................DllDhsKLlpsTspLLhhhsNhphIcc.WphllpssGc.ssshspstlcsahLol.DLpKlps.lshDpp.s...........	1	2	14	27
+8564	PF08731	AFT		Transcription factor AFT	Mistry J, Wood V	anon	manual	Family	AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis .  This family includes the paralogous pair of transcription factors AFT1 and AFT2.	21.60	21.60	21.60	22.40	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.69	0.72	-3.87	8	82	2012-10-02 23:28:20	2006-05-02 13:51:45	6	5	39	0	46	87	0	88.90	35	18.93	CHANGED	FcDKsDIKPWLQK.IFYPQGI-IVIERSDuhKlVFKCKusK+pcstsc........................................................................KKKpus....u+assCPFRVRAsYSl+pK+WolVVlNNsHoHsL	............................................................................Fps+p-l+salpc.hhhspGhtlVIt+Ssp.tlhFpCc.stphpt.t...............................................................................pctsho+h.pCPF+lRAsaSh+pptWslslhsstHsH........	0	10	31	46
+8565	PF08732	HIM1		HIM1	Mistry J, Wood V	anon	manual	Family	HIM1 (high induction of mutagenesis protein 1) plays a role in the control of spontaneous and induced mutagenesis [1].  It is thought to participate in the control of processing of mutational intermediates appearing during error-prone bypass of DNA damage.	28.70	28.70	28.70	28.70	28.60	28.30	hmmbuild  -o /dev/null HMM SEED	410	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.48	0.70	-6.01	4	31	2012-10-10 17:06:42	2006-05-02 15:48:55	5	2	30	0	20	61	6	330.40	38	90.90	CHANGED	LLhGuouLsGKhVhpphLcls.Ylssh.-L.phhLp....ulpphppNlhlppH.........................lhshsR.hhp..p......phh+o.sh.s........htshshpGSQa.......................a.pphpslthDl-plspo.sshs.a-s....ahKscsc..pths.huhhhthK....pasaslpYsouctchlplssshsVsQll.PcSppWPpllP.+IFo..spl-thsh.pc..hP.......ls-IpThISoLGSTSsRs++opsspsalDYhLNhslsKs.Fs....ssssKphlIsTSFNNhhlSps..YF+hKt+LEssLs.slss.LppLsILRPGPLlGcHGs.....PoNssl.c.sushLc+hhhYKKslhpphhpals-h+clGhsTKsSElVApshY+hPGuhllGYslPst+VAalhuhtA......lc+hh+pu..hhcVs..SSpphDshc	...............................................................hhGuouLhGphhLpphLp.phYlts..ppl.p.hhp.....shpp..h.tphhhpph.........................hhshsRp..p.p........hhp..ph.t........hpshshpGuca.............................................a.cphp..phc.hpphs.pss.sshs.acs.t..hhcssscp.pshsthShl..hp.K....phsapLpYsssctchlpIhhshsVhQllhscSppWPcLLP.cIFo.........tplcthshcp....cp....hhP......sLs-.IsTMlC..oLGSTSAcs++opsspsa.sDYhLsasLAQp.Fo......s......Tt.....sK+lVlsTuF.NNshlSphFpYFRhKuKLENDLcpsLs...s+LKcLVILRPGPhsGp....Hus.....Plssplt+...ssshL.p+hhha.+hhh.hphthhtph+phG.t.+ho-llAp.hYphPGs.hlGYslsst+su.hhs..u......hp........p.....cl...pS.phD...s..........................................	0	3	9	16
+8566	PF08733	PalH		PalH/RIM21	Mistry J, Wood V	anon	manual	Family	PalH (also known as RIM21) is a transmembrane protein required for proteolytic cleavage of Rim101/PacC transcription factors which are activated by C terminal proteolytic processing. Rim101/PacC family proteins play a key role in pH-dependent responses and PalH has been implicated as a pH sensor [1].	23.70	23.70	24.50	44.80	22.00	23.60	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.23	0.70	-5.61	24	159	2009-01-15 18:05:59	2006-05-02 16:21:54	5	2	116	0	116	156	2	343.90	28	55.16	CHANGED	sCpshtLssGhll.hsh.t........hphhhsAhapspCsts.........h.ssh....ph..................shppa....ppsppssFhhuhlsllaslusssVhsWhLslllhl....pP.................................ht....................tpshLh+luslhsulhhTlhlscshptlccp.h.pGhhcutpLhchlhsshshpllcllsshhhplsplQllhRlFsRp+cKph..................lhhlGhhlhlsspllaulsphp..ss..........tppstshlsshhhLhclultlhaAuhlhhYslpch.....................+hth...tt+phhhLsllolhllhl.lshFlhDlu....shhltpWuchlshlhtlhssVlsWEWls+lphlE+ctc+puVLGR+l.c.D-hhphc.s....ps	................................................Cpsh.Lss.Ghlh.h.s.t..........hshstsuhat...Csts...........s....................................s.tth.......s...hp-sF..hShhshhaulusssVlsahLslllhl....oPp..................................................shs..t+.shL.+lusLhsAlslTlhhscoh.pshccQat.hG......h.cuptlpsplh...........sshph+llclloshhL.lsQlQhlhRLFs.Rp+-Khh..................IhasGhhLhl.hsslh.slspFh..sst.................spphhsslsshsYLhcLulshlYAuhllaYshpK+..............................................................................+hsa.....th+phhllslLollslllslsFFl.hDlu....p..lssWu-hhpalstssuoVlVWEWlp+lEtLE+cccKculLGRcla-..D-hhchs.t..p...................	0	17	54	98
+8567	PF08734	GYD		GYD domain	Bateman A	anon	PSI2 target	Domain	This protein is found in a range of bacteria.  It is usually less than 100 amino acids in length. The function of the protein is unknown.  It may belong to the dimeric alpha/beta barrel superfamily.	25.20	25.20	25.30	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.64	0.72	-4.26	39	239	2009-01-15 18:05:59	2006-05-02 16:35:35	6	2	184	0	114	254	1015	90.70	27	86.84	CHANGED	YlslssaTspGhcsltcs..scRtcAscphlcs.hGGplcuhahohGp.YDlVslsEuP.DssssuthuLsluutGsV+o.pTlpuhs.s-hpchlt	..............................alhlhsaTspGhcsltcs....scRhcss.pphlcp..h..Gsclc..shYhs.hGp.aDhlslsEuP.Dstshsthu.ltlsutGslco.cThpAhsh--htphl.t....................	0	30	67	88
+8568	PF08735	DUF1786		Putative pyruvate format-lyase activating enzyme (DUF1786)	Bateman A	anon	PSI2 target	Family	This family is annotated as pyruvate formate-lyase activating enzyme (EC:1.97.1.4) in UniProt. It is not clear where this annotation comes from.	25.00	25.00	31.20	81.50	22.30	21.50	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.81	0.70	-5.21	15	82	2012-10-02 23:34:14	2006-05-02 16:42:18	5	1	81	0	47	80	5	247.50	34	72.86	CHANGED	MGGGPlTtAl+cHlcpGhcVhhT.pAAhTl+DDL-+V+uhGIpIs--s.........sssslphtDlDhttlpshlusasl-hshs..lulAVQDHGhuPs.hSsRhaRFc.hh+chL.ppGsp.-cFla..c-sPpt..aoRM+Alhcslccsshtt....hlMDTs.sAAlhGuLp-sch....shpshlllslGNGHTlushl.ccs+IpGlFEHHTshLssp...KLpphlc+hssGcLosEElasDGGHGAal.....suhspscslllTGP+Rplh	....MGGGshstAlppHlptGhpVhso.pAAhTlcDDL-cV.+.s.hGlpIsccs...............ssstlhhtDhDhthlpshhsshulchs.p..lslAsQDHGasss.tSsRhhRFp.hhcchL.pp...........ssp.tshha..pcsPp...hoRhpultcsltts............hlhDTu.sAAlhGsLt-spl...pttpshlllNlGNuHTlushl.pss+IhGlFEHHTuhlssp...cLtphlc+hppGpLssEEVas-sGHGuhh.........tths.thc.lhlsGP+Rph.h..	0	18	37	43
+8569	PF08736	FA		FERM adjacent (FA)	Baines AJ, Finn RD	anon	Manual	Family	This region is found adjacent to Band 4.1 / FERM domains (Pfam:PF00373) in a subset of FERM containing protein.  The region has been hypothesised to play a role in regulatory adaptation, based on similarity to other protein kinase substrates[1].	28.70	28.70	28.90	28.80	28.60	28.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.15	0.72	-4.16	44	1186	2009-01-15 18:05:59	2006-05-03 11:03:47	6	34	97	0	506	928	0	46.50	43	5.71	CHANGED	sphh..shGS+FRYSGRTptQshctspp..htRps.pFpRs.Spptsppps	........pFh..shGS.+FRY....S...GRTptQshcsuph..htR.sspFE.RssSK+hspp................	0	80	119	275
+8570	PF08737	Rgp1		Rgp1	Mistry J, Wood V	anon	manual	Family	Rgp1 forms heterodimer with Ric1 (Pfam:PF07064) which associates with Golgi membranes and functions as a guanyl-nucleotide exchange factor [1].	31.00	31.00	31.00	31.10	30.40	30.40	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.22	0.70	-5.40	30	392	2009-01-15 18:05:59	2006-05-03 12:51:38	5	4	255	0	271	363	0	254.90	21	59.05	CHANGED	psLhhuasQIpGphplstshls....sshpt.ppp..hht..........................tt.tp.tp.t..............h.phh.sssphstshsthhststpss................................................................................pcslPlhoTPpolLFsDLpLsPGEoKoFpa.shsLPpsLPPSa+.Gps.........l+lpYsLslGspc....................sttsppsptlplPlRVhs.hptt..................h.tsl.pshhhlccptplphhssppptsssshht............................spcss..........pphpphhchlppLlspcs.p....................p.p...........................................................................tspapIspsscpluplsLsKshY+lGEslshsl-hssss....htshtlsssLEopEp.................lssph..............................tlpusspspp.............sstpshsppppsshpsp.plshplsIPhssT....PpFpTshlp.....LcWpL+FcFVhsp	.............................................................................................................................................................................................................................................................................................................Lhsph.l....sp...........p.a....h.p..lP........hPsoap.uts.........hph.Y....l..hluhph..............................hplPhplh........................................................................................................................................................................................................................................................................................................................................................................t.aplt..stthlshh.h...cs...h..at..hG-.l.hhhpht.tt...................h.shth.pstLps..Eh.................................lt.th..................................................................................h.hhsp..t.sh..h.ph.h..slPhpss....sth.....Ts.......hhp...........hpW.lphcFhh..t.........................................................	0	83	135	213
+8571	PF08738	Gon7		Gon7 family	Wood V, Bateman A	anon	Wood V	Family	In S. cerevisiae Gon7 is a member of the KEOPS protein complex. A protein complex proposed to be involved in transcription and promoting telomere uncapping and telomere elongation [1].	21.80	21.80	22.10	21.80	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.39	0.72	-4.03	18	104	2009-01-15 18:05:59	2006-05-03 14:02:37	5	1	102	0	75	92	0	97.40	31	80.47	CHANGED	l.sAsYouPsssp.csFchshs.P.........ot.Sths.pAuspsp-csocsKs.............sYLucLRspLosLQDcINhFLTpRMEc-Kpttttputt.t......p-cpEcchhs	.............................................hA.YpuPs..p..ppFt.t.s.s......................su...t.s.psp.sops.+s.............sYLupLRstlssLQ--INpFLTpRMEc-Kpcptt.tutttp..........p-pc-cc.hs.....................................................	0	11	35	63
+8573	PF08740	BCS1_N		BCS1 N terminal	Mistry J, Wood V	anon	Pfam-B_10126 (release 19.0)	Domain	This domain is found at the N terminal of the mitochondrial ATPase BSC1.  It encodes the import and intramitochondrial sorting for the protein [1].	22.40	22.40	22.60	22.40	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.07	0.71	-4.68	55	539	2009-09-16 12:49:40	2006-05-03 16:25:19	6	9	253	0	410	534	1	175.50	25	35.62	CHANGED	hhlGsshuhh+phhphhhph.....hpcphhsolElss.....cDcsYsallpW.huppshsph.pp..ht..t....................................................phthpsphtpcp.................ppphpasPu.G.sHahhYcG.p..hltlpRp+.pppthshss.t.s.........hEslsloslupstplhpcLLpEA+phhhpppcu+..TllYputusp.........Wpp.stsRtpRPlsoV	...........................................................................h.hhusshthh+pshphshth.....hpcphhsol-lss.....cDc.sYsal.lpW.lsppsttp..t...pp..ht.............................................................t.t.h.p..sph.pcp.....................psphpahPu.G..pHhhh......Ycs.p..alhlp...Rp+..ppp....hshts...s.s................hEsloloslup.s....pp....lhpclLpEA...+p..hsh.pppcu+..TllYpuhusc.........Wp..stsRtpRPlsoV...................	0	114	215	349
+8574	PF08741	YwhD		YwhD family	Bateman A	anon	PSI2 target PSI-blast from BH3813	Family	This family of proteins are currently uncharacterised.  They are around 170 amino acids in length.	25.00	25.00	81.10	80.80	20.90	19.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.97	0.71	-4.84	13	388	2009-01-15 18:05:59	2006-05-04 13:58:48	5	1	383	0	44	165	0	163.10	67	96.27	CHANGED	KKp..huFNIIKsDsTDGHGGaGsGoLSL-NVSPVhlDlE-pcAFVDlGAMHARSsVEKtIKFlss+--Vs..sGK.YWLVWVTl-RpE-GPYYAGVTACEMsVs+EhRR...GYKSLPEHVN+MDKSlK++IlV-HMD-sSKplLu-FLcsHs.sMWp+Ss-EL+cuLt	..............KKshsFNIIK.NDPhDGH+GhslGSlSLDNIuPVFIDVtsKEAFlDIGuMHARucVEKGlKalT-KstV...puKtYWLsWVTsERsEp.GPYYAGlTAC.hhVs+sIRR...GYKShPEHVNhMDKSMK+HIIlDpls-csKtlL+-FLhsHsEuMWpcSS-tL+pAh.p...	0	14	27	36
+8575	PF08742	C8	DUF1787; 	C8 domain	Mistry J, Liu XH	anon	Liu XH	Domain	This domain contains 8 conserved cysteine residues, but this family only contains 7 of them to overlaps with other domains. It is found in disease-related proteins including von Willebrand factor, Alpha tectorin, Zonadhesin and Mucin.  It is often found on proteins containing Pfam:PF00094 and Pfam:PF01826.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.93	0.72	-3.73	131	2979	2009-01-15 18:05:59	2006-05-04 14:10:28	6	390	118	0	1758	2535	1	74.30	30	11.28	CHANGED	pttspphCphlh.sst...FspCHshVsPpsahpsClhDhCt.....stss........psh.CsslssYApsC..pptGlslp..WRs...shCs	.........................................t...spphCshlh..sss..........Fts.CHs..h..V...s.P.p.s.ahcs..C..lhDhCt...............ssss............p...psh.C.sul...ssYApt.C......p.p...t..G...l......s...lp.....W...Rs...shCs..................................................	0	299	442	1045
+8576	PF08743	Nse4_C	SUMO_ligase; Nse4;	Nse4 C-terminal	Mistry J, Wood V	anon	manual	Domain	Nse4 is a component of the Smc5/6 DNA repair complex.  It forms interactions with Smc5 and Nse1 [2]. The exact function of this highly conserved C-terminal domain is not known.	19.60	19.60	19.80	19.90	18.20	19.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.07	0.72	-3.96	24	357	2009-01-15 18:05:59	2006-05-05 09:24:19	5	11	270	0	259	358	0	89.00	29	23.74	CHANGED	pslshhcFVlNP...pSFuQTVENlFalSFLl+-GtspIphc.pcslPhlps..t.s.tsstspstsst+pQuVhslDhcsWcphlchasI..pEshlspc	...........t.slshacFllsP...pSFupTVENlFalSFLl+DGplplphD.....pc.s....l.......Phlps...........t..s..........ts...p......t......hp........p................pshtppQh.lhslshpsWcphlc..hapl..pcshl.......................	0	83	137	208
+8577	PF08744	NOZZLE		Plant transcription factor NOZZLE	Mistry J	anon	Pfam-B_86265 (release 19.0)	Family	NOZZLE is a transcription factor that plays a role in patterning the proximal-distal and adaxial-abaxial axes [1][2].	20.20	20.20	20.30	21.00	19.40	19.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.26	0.70	-5.06	2	13	2009-01-15 18:05:59	2006-05-05 10:55:01	5	1	7	0	9	13	0	216.80	34	57.38	CHANGED	MATSLFFMSTDQNSVtNPN-LLRNThLV...sGEIRTE.shKSRGRKPGSKTuQQpQKcPTLRGMGVAKLER.hhEEEKKph.ssAs.GDTS..Au.sNsATRhP...D.GVVLQGFPS........SLGu...sRhhCGGsGSGQlMIDPVhSPWGFVETSu..HELSSIsNPQMaNASSNp.CDTCFKKKRLDGDQ.NVVRSNGGGFSKYTMh..PPPMNGYDp.LL.sD..QRSQGFhYDpRIARuA..sAuSsohNPYFNEATNhTG.shEEFGSh...NPRNGotGVKEYEFFPGKYs-hhuhsh.suo.VGDCSPN...TIDLSLKL	........................s..........................................h.p.shpoRuRKssoKpupppQKK.s.RGMGVAQLERlRIEEcpKph.shAs...us.....sS.........hp...s.phsp.s...s.G.s...............................G....sh..s.uhGuG.hhlsPhhs...s.t.st..st......+ELSShsp.........p.CDhCFK................................................................................................................................................st.............................................	1	2	8	8
+8578	PF08745	UPF0278		UPF0278 family	Bateman A	anon	PSI2 target MJ0950	Family	Members of this family are uncharacterised proteins about 200 amino acids in length.	22.50	22.50	22.50	22.50	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.46	0.70	-5.08	11	103	2012-10-03 20:43:45	2006-05-05 13:00:30	6	2	91	1	79	113	3	182.50	35	88.86	CHANGED	RFVLDTosFT-splRcthG.cslsEuscphLDLIucARlphsISCYlP.PoVYpElppFhcp.ssstElls+l-TWllKKoPsRYEl+IPAplFYEYlc-lRcRls+GhRlAEctlh...Euuspsh............cpp...-.lGclIschRcKYRpsLRpGhLDSs.DlDVLLLApELDAuVVuuDpGIc+WA-+LGLRalsussFPphLcEYLch.	..............................................................RFlLDTohhsssplRp.hG.ps.scuhpphlclhtpsch.htlphahP.solYpElhthhp.....tclhscl-hallhKsPs+aplpIPu.lhYEalc-hRpRls+GhRluEctlh...cus.ts................................p.lsphIpphRc+YRpALRp.GhLD..SptDlDlLLLAhELDAslVosDtGIppWAc+lGl+alsutpF..hLcphlp.h..............................	0	19	42	61
+8579	PF08746	zf-RING-like		RING-like domain	Mistry J, Wood V	anon	manual	Domain	This is a zinc finger domain that is related to the C3HC4 RING finger domain (Pfam:PF00097).	22.90	22.90	22.90	23.20	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.95	0.72	-3.96	12	210	2012-10-03 15:03:13	2006-05-05 13:42:37	6	5	176	2	141	204	0	43.10	37	14.10	CHANGED	CphC+clshpG.tCss.sCshc............hHhtChppahpppss..hCP...sC	...CphC+cllhtGppCs..s...pCsh+...............hHh.Chp+aapppp.....t...pCPpC.......	0	27	60	102
+8580	PF08747	DUF1788		Domain of unknown function (DUF1788)	Bateman A	anon	PSI2 target Npun02004481	Domain	Putative uncharacterised domain in proteins of length around 200 amino acids.	21.80	21.80	22.10	22.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.50	0.71	-4.27	24	273	2009-01-15 18:05:59	2006-05-05 16:38:57	6	1	261	0	68	239	41	125.00	30	65.39	CHANGED	lhclsLa-lsl-lLc-Rtlh-cllchEpppGp-tlhctLpulLc.......pcclsptIscp.htstshDllhLoGVGpsaPhl.RoHslLNNLpshhtppPllMFaPGpYs.....GpsLcLFsplc--s...YYRAFpll	...........................................h..phslaplhl-hLpc+..s.......h..h.-...p.....hhp....hE.p..h....Gt...-tlhc.tlps.Lp................pcclsphIsc+....h...t......h..s.s.ps..lVhLTGlGpsaPhl.RuHplLssLp..s..hhs.psP..llhFaPGpYs.....GpsLplFs....phcspN...YYRAFpl.........	0	30	49	59
+8581	PF08748	DUF1789		Domain of unknown function (DUF1789)	Bateman A	anon	PSI2 target CAE43632.1	Domain	Putative uncharacterised domain found in phage-related conserved hypothetical protein from Bordetella.	21.10	21.10	21.30	21.80	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.51	0.71	-4.04	16	124	2009-01-15 18:05:59	2006-05-05 16:46:41	6	4	104	0	23	102	2	103.00	28	77.82	CHANGED	MA..KhsL.........utsP.TF+hsVplshhsGpsscl.F.............TFKah..sppElt-lhppts....................pp......................................ss-hlpplssGWs.l--cFs-ENlphLlspasuAspAllsAY.pAlstsRlGN	....................................................Mu...hhpL..........spP.TFchsVpIPhsGt.css..l.ph.............sF+ah..shp-ht.ph.p..t....................tt........................................sh-hhhchlpGWs.......l-..-.....sFscENlphLhssYPt.AspAlhssYhptlhssRttN............	1	1	11	19
+8583	PF08750	CNP1		CNP1-like family	Bateman A	anon	PSI2 target CAB84161.1	Family	This family of proteins are likely to be lipoproteins. CNP1 (cryptic neisserial protein) has been expressed in E. coli and shown to be localised periplasmicly [1].	25.00	25.00	77.60	77.30	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.78	0.71	-4.49	22	187	2009-01-15 18:05:59	2006-05-05 16:59:41	6	1	186	0	53	147	10	146.50	39	75.01	CHANGED	..h.pstsWcEtps.tLP.shPpspsLlsFsV....ussos.pFhlDscSloVG.sDGVVRYslVlsSsuGA+NVsYEGIRCsoh..........Eh+hYAthsss.spWstsppsp....................Wptlpss.shNpapusLhp-aFCssts.ssts..sspllpsL+s	..................sttppacEpps.pLP..PLP..psp..shl.Fsl....s.sss.+ahlDupSlslu.sDGlVRYhlllpSss.Guc...NlsaEGIRCs.sh..........ca+hYAhhssspspW.pspps-....................Wp.Itss.shNshttsLhpphFCpsth.Psts..spsllppl+...............	0	9	30	41
+8584	PF08751	TrwC		TrwC relaxase	Mistry J	anon	pdb_1omh	Domain	Relaxases are DNA strand transferases which function during the conjugative cell to cell DNA transfer.  TrwC binds to the origin of transfer (oriT) and melts the double helix.	22.80	22.80	23.00	23.30	22.30	22.70	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.93	0.70	-4.99	34	741	2009-01-15 18:05:59	2006-05-08 13:13:30	6	26	467	20	202	783	45	275.90	33	24.11	CHANGED	thpssusussYYpsps.....................sYYt......pspssspW.hGpGupp.......L..........GL.sGpl..s.ppphtpl......l.sGphP...........sGptlsps.t....t.....................................................................................................psGaDLTFSAPKSVSllhhluuD...ccll.pAHppAVstulph.lEcphu.sRtsppGp....th.pss.sLlsutacHcoSR...........st.........DPpLHTHsllhNhs........................................hssDG....pWRoLsuc..............placpphthGtlYpupLtpcl.ccLG..aphc.........cpGsaEltGls.pchlctF..SsRsppIcpthuc.u.............ssstttcph......AshsTRpsK.pps.shsplcptWppcupph..Gh...-h	...........................................................................................................................................t....ttuhtYatpp.................................sYYs............sp....stpW..hGpG....Apt...................L.................GL..pGps.....s.pp.h..ppl........l..p.Gp.hP....................................sGtp..l...s...p..h..............tt.....tp......................................................................................................................................................................................................psGa.DLTFSAP.KSVSh....h..........th..l...........usD...............c.......plh.pAHppAVp.s........lp..lEp...h...u....s.Rhtps..Gt.........th..Ts.sLlhAhFpHcTSR............................st.........D.....PpLHTHsllhNhs..........................................p..t.s.G..........cW+..s..Lssc..............sla.tp.phsh..utlYps......p......Ltpp......l.ctlG...aph..c.............cps....h..aEl..........sGls...........t...................l-s.F..SpRspp.....Iccthsp..........................................ssshpt+ph............AslsTRpsK...p...ps......s.p.hhtpWhpphpph..Gh..h........................................................................	0	61	144	184
+8585	PF08752	COP-gamma_platf	Gamma-COP;	Coatomer gamma subunit appendage platform subdomain	Mistry J	anon	pdb_1r4x	Domain	COPI-coated vesicles function in retrograde transport from the Golgi to the ER, and in intra-Golgi transport.  This is the platform subdomain of the coatomer gamma subunit appendage domain.\	      It carries a protein-protein interaction site at UniProt:P53620, residue W776, which in yeast binds to the ARFGAP Glo3p, and in mammalian gamma-COP binds to a Glo3p orthologue, ARFGAP2 [1].	25.00	25.00	25.20	25.00	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.73	0.71	-4.40	81	438	2012-10-03 16:25:20	2006-05-08 13:33:25	5	10	295	2	300	436	6	145.80	42	17.35	CHANGED	ppppYsppLusIP....cht....sh.GslhKSS.p...slpLTEsETEYsVsslKHlF..ppHlVlQFslsNTLsDplL-sVsVhhsss...-st.......h..pphhhlPlspLs..h.spsGssYVshpt.....s.sshshusFus.sL+FhsKE.lDPsTG.-s--....-GY-DEY.lE-lElss	...........................................t.tphatcpLutIP.....Eht...sh...GsLhKSS.s....PVpLTEuETEYsVpslKHl.F..spHlVh........Q.......FcssNTL.....sD...plLEsVoV.hpss...-s........a..p.hhhlPstp.Lsh..s.pPGtsYlhhph..............s-.ssh...........sssoF...us.sLKFssK-.sDPsTG....Es--.....-GY-DEY....lEDl-ls.h.......................	0	101	159	238
+8586	PF08753	NikR_C		NikR C terminal nickel binding domain	Mistry J	anon	pdb_1q5y	Domain	NikR is a transcription factor that regulates nickel uptake. It consists of two dimeric DNA binding domains separated by a tetrameric regulatory domain that binds nickel.  This domain corresponds to the C terminal regulatory domain which contains four nickel binding sites at the tetramer interface [1].	20.90	20.90	21.30	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.42	0.72	-4.09	39	1066	2012-10-02 00:29:19	2006-05-08 14:04:46	6	4	979	79	297	602	67	78.40	43	56.69	CHANGED	sGslsllYDHcppsLspcLsslQHcapcl.....IloohHlHLDccpChEllll+GpupclpcLucclhuh+GV+au+Lshsss	......................uVLohVY-H.c.pR.-Lup+lsshQHcHHDl....sluTLHVHl....s....H.-c.C.LElhlLKGchu-Vp+hADclhAp.RGV+HG+Lpslsp..........	0	76	181	243
+8588	PF08755	YccV-like		Hemimethylated DNA-binding protein YccV like	Mistry J	anon	pdb_1bvb	Domain	YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression [1].  The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.41	0.72	-4.07	64	1071	2009-01-15 18:05:59	2006-05-08 14:58:45	6	15	964	1	318	578	1189	98.80	44	47.48	CHANGED	puKFpIGQlVRH+hasaRGVlhDlDPpFsso--WacsIst-h+..Pt.+cQPFYHlLsEscps.............phl.uYVuEpNL.....h.DssspslcHPpl....schFpphcsu..tYh.c	.......................s.uKFuIGQ.V...R.Hp..........Lh..G..Yh....GVV........l......DlDP..a..u..hsE..........-p.....ls.........ss.c..............ph..RstP......aYHV.lhED-.su.............................V..sYlAEtpL........ps-hpsE.cscpPsh....-Elhpshcpp..h.ts.+.....................................................................................	0	90	160	239
+8589	PF08756	YfkB		YfkB-like domain	Bateman A	anon	PSI2 structural target yfkB	Domain	This protein is adjacent to YfkA in B. subtilis.  In other bacterial species it is fused to this protein. As YfkA contains a Radical SAM domain it suggests this domain is interacts with them.	25.00	25.00	25.80	190.60	20.20	17.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.95	0.71	-4.64	14	371	2009-01-15 18:05:59	2006-05-08 16:01:15	5	6	371	0	42	183	0	153.50	70	40.66	CHANGED	MYPuDFASsLEsLSLcEhRcAIH+LLDhRDcslWMLFGTLPFYPCSssEEDhcLL+RLhpppNVTVRNDPDGRSRLNVNIFoGslIVTDFGDp.PsLGNIps-sLs-AYs+WppoclA+pLNCHCPuVpCLGPNVLVKNsYYp-sDFpp+pA+l	MYPuDFASpLsVLTLAEM+csIHclLDhRDEslWMLFGTLPhaPC.cD--DQ+LLpRLRpuKNVTsRNDPDGRSRLNVNlFTGNVIVTDFGDE.ssluNIQcD+LsDVFDKWL.u.ScLAKSLNCHCsphpCLGPNVLVKNMYYPshDF+cpctp.h..	0	12	25	34
+8590	PF08757	CotH		CotH protein	Bateman A	anon	PSI2 structural target cotH	Family	Members of this family include the spore coat protein H (cotH).	24.60	24.60	24.60	24.80	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.02	0.70	-5.19	53	707	2009-01-15 18:05:59	2006-05-08 16:09:44	6	49	471	0	258	662	798	299.10	19	51.59	CHANGED	l+hRG..so.......opph.sKKSa+l....c.hcpt..............th.Gh............cchhLpspatD..sohhRspluhclhcph...........uhssspsp.....asp..lalNG.........cYhGlYhh..hEplc.cphlctc..htsss.........utlacss................t..sh..t...ptth........ppssptshsplhs.hlphlsss....s.tphtstlpphlDl-salcahshptlhsNh...D.sh....scNhaLa..............tspss+aphlP.WDhDtuauphhp............................................t...thh.hsttssLh..p+llps..ssa+pphppphppll..pshhstptltshlcshtshls..sthpp-stthtsht..........................phppphphlppalppRhpal	....................................................................................h+G..sp...............t..t..h...+p......sacl...........p.hpph................t.h.Gh................cphhLp.s.....t.h......D...............oh.hRptlu..hphhpph.......................................sh...s.sps.p......ast.....lhlNs......................................ph.GlYh......hEp.lc..cphhc...tp.....hhs..ss.........................................uhhaphs...............................................................................tt.sh.......tt.........h............................p.t.ts.......pp..s.....hptl...p..hlphhsss........................ttth....ptltphlDl.-.p.hlcahshp.hhtNh......D.sh............spNhhla.............................ttpsshap....hlP..WDh.-hsautt.t.........................................................................................................................thh.t...t...ss.Lh...tpllp......stappthpp.h...hpc.lh..........p..p......h..s....phh.sh.l.pphtphlt......s..h..p.s....h.h..h.............................................................thpt.tht..l..phhptR.t...........................................................................................	0	146	211	244
+8591	PF08758	Cadherin_pro		Cadherin prodomain like	Mistry J	anon	pdb_1op4	Domain	Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion.  They are activated through cleavage of a prosequence in the late Golgi.  This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions [1].	21.40	21.40	21.40	21.40	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.86	0.72	-4.21	52	421	2012-10-03 16:25:20	2006-05-08 16:13:35	6	13	48	1	158	409	0	82.30	30	10.07	CHANGED	sCpPGFppcsashplspc.lpcGp.L........hpVpFssC.sGpp+lpYpoo-s.cFKVssDGolhstRslplpscphpFhVaApDspscc...............hslpltl	...................................p.h..h...lspp....l.ttp.l........hp...VsF..p-C..ts..ppplta..pSSDP.cF+VtpDGolassRslh..L.s....s..cp.....t..s.FhlhupDspspc....hpltV..l.....................	0	7	17	64
+8592	PF08759	DUF1792		Domain of unknown function (DUF1792)	Bateman A	anon	PSI2 structural target AAO75156.1	Domain	This putative domain is probably missannotated as a glycosyl transferase 8 family member. This domain is found at the C-terminus of protein such as Swiss:Q97P75 that also contain the glycosyl transferase domain at the N-terminus.	20.80	20.80	20.80	35.90	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.44	0.70	-4.74	19	183	2009-01-15 18:05:59	2006-05-08 16:19:41	6	4	170	0	25	154	14	215.50	52	33.74	CHANGED	VsRFGDGEhsll........tGcsIsaQsa-scLAp+L+cll.ppscp..shlVCLPDsFp.sltcYsphuppFW+sahhhhsshapchh.....ssphYusTFlSRPYhDhtD....KspustaFccLKpIWcs+DlLIVEGtpSRuGVGNDLFcNs+SIcRIlCPu+sAap+hccIhptlpch.....ucs+LILlhLGPTAKVLuaDLtchGaQsIDlGHIDoEYEWa+MGAppKVKl.ppKasAEhN	.........llRFGDGEhsLh........hG.psIsYQsaD.ELAppL+cll..th..pSsE...cLlVCLPD.s.Fc...sh.pas.hupsFW+.pHh..hah-hYpcls.....pusaYGSTFISRPYI.DhcD....Kop..utuhFcKLKplWcsRDlLIVEGhsSRSGVGNDLFDpspSl+RIICPS+NAYSpl-pIpptlh.ca......Acs.+LILhMLGPTAKVLuYcL.s.phGY...QslDlGHIDSEYEWh+MGAppKVKh.uHKHTAEaN...........	2	4	11	17
+8593	PF08760	DUF1793		Domain of unknown function (DUF1793)	Bateman A	anon	PSI2 structural target AAO78587.1	Domain	This presumed domain is found at the C-terminus of a glutaminase protein from fungi [1]. This domain is also found as a single domain protein in Bacteroides thetaiotaomicron.	19.40	19.40	20.00	20.70	18.10	19.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.04	0.71	-4.39	37	301	2009-01-15 18:05:59	2006-05-08 16:38:11	6	11	161	0	170	307	0	170.00	37	23.78	CHANGED	lGltAhuclAshhGcstsAppYsslAcphhscWt.phuh....-us.......HhpLsa.sp.uoWo.hYNLhhD+LLsLs.........................................................lhPpplachpssaYhohppcYGlPLDoR+s.YTKoDW.hasAslussp.shpthlsslhpalsETsochPhoDhY-Tp..sGshss........FhARsVVGGaFhhLhh	................lGltAhuplAphhG...p.p....ssA.ppYpshAcphsscWp.phuh....-us.........Hh.+Lsa...cp...s.oWophYNLh.hD+LLs.Lp....................................................................lhPppVhptpssaYhs....h....p..pp...YGlPLD.......oRc.p.....Y...T.KoDW.hasAuhussp....shpphlsslhpahNETsochPhoDhapTp..sGphss..........FtARsVVGGaahhlh....................................................	0	67	109	144
+8594	PF08761	dUTPase_2		dUTPase	Mistry J	anon	pdb_1w2y	Domain	2-Deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and pyrophosphate (EC:3.6.1.23).  Members of this family have a novel all-alpha fold and are unrelated to the all-beta fold found in dUTPases of the majority of organisms [1].  This family contains both dUTPase homologues of dUTPase including dCTPase of phage T4.	23.00	23.00	23.00	23.10	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.25	0.71	-4.16	34	876	2012-10-01 21:36:44	2006-05-08 16:42:01	6	2	693	18	118	593	126	152.60	27	88.39	CHANGED	sLpplhchQctLspclspcp.......pt.ph......hh.pp..hAlhsEluEhhsch...........tsaKaWKspp.............scttp...............................................lh.EhVDslHFllSlslphthp..........................................t.hs.ph.pt............hh.......phhtphpphhpp..st...pht.lhsthhtls.hlGhs.--lhctYhtKNplNatRQspGY	..................................LpphhplQcchscclstpp.............p..p.................h...h..huhhlEhuEhhsph...........p.s.aKhW.Kpps............spsh-s.........................................................hlpEhlDhlHF..h..LS.lslphhhppp.......................................tt..h......shhpp............................................hh............phhtp.h...p.h..h...tp...s...........ht...hht.a..htls.h.t.ht.......ash-plhcsYhtKtthNatRQs...........................................	0	41	92	106
+8595	PF08762	CRPV_capsid		CRPV capsid protein like	Mistry J	anon	pdb_1b35	Domain	This is a family of capsid proteins found in positive stranded ssRNA viruses such as cricket paralysis virus (CRPV).  It forms an all beta sheet structure [1].	21.10	21.10	21.20	21.20	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.31	0.71	-4.88	7	192	2012-10-04 01:49:40	2006-05-08 17:16:02	5	14	36	2	0	153	0	163.40	32	24.60	CHANGED	o..s.h.hhhGEplsslRpLl+RFphh.t......ptsssl.chsplppPt............tst.shshh.......shhualYtFaRGuhRaKlhshps...................t.....s..lshhtTsspsspsssuh............hh.sslpshtEhplPYYu.....Psss.s.ts.s....psl...psh.s.sltpt.psp.......sthhhRA.uuDDaoFuhLlGsP.h.hssup	..................................................................tsh..............................................................................................................h...............shluphYthYRGGlRhKllscps.........................................l.c.hsp.ss.s..sspps.hsSc........................s.tlp.hslpsVtEhplPYYu..........Pshoso..pups..................ph.....pGt..s..s..hslssss.suh.................sph..h....slu.AGDDhsFShalGsP.h..t.s................................................	0	0	0	0
+8596	PF08763	Ca_chan_IQ		Voltage gated calcium channel IQ domain	Mistry J	anon	pdb_2be6	Domain	Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential.  The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin [1].  The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).	20.70	20.70	20.70	21.40	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-7.80	0.72	-4.71	25	724	2009-01-15 18:05:59	2006-05-09 09:54:38	6	7	96	16	235	602	0	34.30	52	1.83	CHANGED	sD-VTVGKFYATaLIQDYFR+FKp+Kppptpppps	.....DElTVGKhYAoaLIpDYFRpaKp+KEpthht...s.....	1	33	56	116
+8597	PF08764	Coagulase		Staphylococcus aureus coagulase	Mistry J	anon	pdb_1nu9	Domain	Staphylococcus aureus secretes a cofactor called coagulase. Coagulase is an extracellular protein that forms a complex with human prothrombin, and activates it without the usual proteolytic cleavages.  The resulting complex directly initiates blood clotting.	20.70	20.70	20.80	20.70	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.89	0.70	-4.47	11	424	2009-01-15 18:05:59	2006-05-09 10:55:11	5	11	168	6	3	229	0	256.90	41	46.40	CHANGED	TKDYStcSpVNcsSKpGosISstYaWuhIcsLEsQFspAlcLlEcYpYGEKEYKDAKDKLMTRILuEDQYLLEKKhspYEhYKchYKKaKcpN...Ppsp.hKMtsFacYslYsLTMcEYN-IppSLK-Al-cF+p-Vc-IppKNpDLKsYsccpEcKATccVYDLVsElDTlasuYauDppaspcAKELRAKLDLILGDpcsPpRITNERI+KEMhcDLNSIIDDFFhETsQNRPssITKYDPshHDY+...-NKpsFDALVKET+-AVscADESWKsKTVKKYG	................................................tK.st.hss.hh.thlp.tLts.hh.uhslhc...p.cYs-.EYK-AhDKhhp+..lhuEDphL.p+hhtthc.hKcaapptpp..........tp.hph..hp..hcphs....lhsLThccYsplapoLKcshc-Fp+EVccIppKNsDLKs.a........s........cs...c-p+...As........scl..c..L.scl.h.l.....shs.aa....sc..p....patccsc-LhuKL..DLILG...-...pc...c...s....+.+.....h...TNcRhtcEhh-DLpoIID-FFh-hppNRPpsIsph.sss.c.H.s.p....cN+tNh-pLhp-TctAh.tcuD-Sh+p+psK.......................................	1	2	2	3
+8598	PF08765	Mor		Mor transcription activator family	Mistry J	anon	pdb_1rr7	Domain	Mor (Middle operon regulator) is a sequence specific DNA binding protein.  It mediates transcription activation through its interactions with the C-terminal domains of the alpha and sigma subunits of bacterial RNA polymerase.  The N terminal region of Mor is the dimerisation region, and the C terminal contains a helix-turn-helix motif which binds DNA.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.32	0.72	-4.27	17	765	2012-10-04 14:01:12	2006-05-09 12:02:26	6	4	521	1	130	526	7	97.00	22	79.65	CHANGED	s+hP-lLs-LsphhtptLpchs....l-.tt.AcpluhplAspluppaGGpslYhPpGhshchs.RDhcIas-Fs........GcNhtpLAR+YslohphIYpll+RhR+pchpcpQhc.L	..............................h.....................................p.h.u..p......hs....tplhphhG..Gp.......p.l.YlP...........+............s....p............p...........h............p............t............p............h.Rs..ppIhp.-.a.s............G..p.s.h...p..cLAc+YtLS.pplhpIlpc.ct..................................	0	57	101	114
+8599	PF08766	DEK_C		DEK C terminal domain	Mistry J	anon	pdb_1q1v	Domain	DEK is a chromatin associated protein that is linked with cancers and autoimmune disease.  This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteristic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients [3].\	    The structure of this domain shows it to be homologous to the E2F/DP transcription factor family [1].  This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphastases such as Swiss:Q6NN85.	24.80	24.80	24.90	24.80	24.50	24.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.18	0.72	-4.19	59	900	2009-01-15 18:05:59	2006-05-09 13:39:52	6	46	294	1	579	859	1	53.50	28	6.68	CHANGED	o-pplpptlcclLpsu.DLpslTp.+plRcpLpp+h.sh-L.s..s+KshIcphlcphLs	........-ptlppplcpILpss..D...Lps.l...Tp.KplRppLEpc....h..sh...sL.s...p+KsaIcptltthl.......................	0	169	305	449
+8600	PF08767	CRM1_C		CRM1 C terminal	Mistry J	anon	pdb_1w9c	Domain	CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran.  This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat [1].	20.20	20.20	20.30	20.20	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.87	0.70	-5.52	29	475	2012-10-11 20:01:01	2006-05-09 14:14:28	6	15	300	13	326	464	6	280.10	33	28.82	CHANGED	QLupIYhDhLplY+hhSphISptlsttG.hsoK....pshl+shRolK+ElLKLl-Talp+up.....................................s.p..VhpshlsPLh-sVLhDYpp.NVPsAR-sEVLsshsollsKlps....hhpstlshIhcuVF-sTLsMIscDFp-aPEHRlpFapLLculstpCFsAllp..lssppFKhllDollWAhKHspRsVt-sGLslhh-llpNlpp............ssphuppFYpsaahslLp-lFhVlTDos..HKuGFphpshlLtplhpll-ss.....plssPlhs........hssNthalppalsshLpsuFsplstpQlpsFlpuLaphsp.s...................htpF+tplRDFLlplKEFuu	..................................................................................................................................QlshIahDMLsh...Y.+hhSp.Isttltt...t.............G..hs.s.+.............pshl+.th.RslK+EhL+Llpsalp+up..........................................................................................................s.p.....lhpphl...ssL.hcsVLhDYpp..s..lPsAR-sEVLs...hhssllpK.ltt....................hh.t.spl...s.I...h.csVF...csTLsM........I..s..cD.Fp-..aPEHR...spFapLLpulsppC....F..su.........llp.....ls......sspFKhll.DSl.hWAhKHspRsVsp..s...............GLphlhpLlpNhtp.................ptthuptFap...s.aahplLpclF.V.l.TDsp..Hp..uGhphpu..lL.tth.hpllp.s.....tlp.sl.s......................sNt.alp.palsphLpsuF.....splptt..........p....lp.Fl.pu..Lhp.tp..s...................................................hstF+tplRDFLlplKEas...............................................................................	0	131	195	269
+8601	PF08768	DUF1794		Domain of unknown function (DUF1794)	Mistry J, Pollington JE	anon	pdb_2fr2	Domain	This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.	25.00	25.00	25.20	25.40	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.06	0.71	-4.37	55	758	2009-01-15 18:05:59	2006-05-09 15:33:03	6	9	575	7	271	552	113	161.40	28	72.68	CHANGED	ssLsPLuhLlGsWcGc..GtuthPsh....p.sap...YtEclsFs.as....Gp.....shLtYp..t+................oath....ssGp....PhHsEsGahRh...psssp...................................l-hhlupPsGlsElhhGp......ssusplcLs.scu.....lspostu.+..pss...........................uhpRhaslh..ssssLsYshch.t.....shsp...s.Lpp+hsupLcRh	............................................tLhsLs.LlGsWcGc.....Gp.ushPs.............t.sapaspplsas.cs.........Gt.........sa..Lsap..sp.................................................oaph.............ssGp........Ph+pEs....GaaRh.....ssssp..............................................l-llhupssGhsElhhGp........hsss.p..l.cLt..ocu........lucostu.p......pss...........................shpRhasls.....pss.s.Ltas.ch..h.....ssss.....s.lpsahsApLcR...................................................	0	79	160	239
+8602	PF08769	Spo0A_C		Sporulation initiation factor Spo0A C terminal	Mistry J	anon	pdb_1fc3	Domain	The response regulator Spo0A is comprised of a phophoacceptor domain and a transcription activation domain.  This domain corresponds to the transcription activation domain and forms an alpha helical structure comprising of 6 alpha helices.  The structure contains a helix-turn-helix and binds DNA [1][2].	25.00	25.00	25.40	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.33	0.72	-4.17	28	674	2009-01-15 18:05:59	2006-05-09 15:37:23	6	2	490	7	111	516	13	102.40	58	44.53	CHANGED	clTsllHclGVPAHIKGYpYLR-AIhhslp-sclLsulTKpLYPpIA++YsTTsSRVERAIRHAIEVAWsRGph-slschFGYTl.........................stp+GKPT.....................NSEFIAhlADKLR	................lTsIIHEIGVPAHIKGYhYLR-AItM.VhpDh-.lLuulTKhLYPsIAKKYs.TTsSRVERAIRHA.IEVAWsRGs.l-sIsplFGYTl...........................s.sK.uKPT.....................NSEFIAhlADKLR............................	0	59	93	100
+8603	PF08770	SoxZ		Sulphur oxidation protein SoxZ	Mistry J	anon	pdb_1v8h	Domain	SoxZ forms an anti parallel beta structure and forms a complex with SoxY.  Sulphur oxidation occurs at the thiol of a conserved cysteine residue of the SoxY subunit [1].	20.00	20.00	20.10	22.10	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.87	0.72	-4.58	88	444	2012-10-03 16:25:20	2006-05-09 16:07:57	6	2	281	14	195	457	292	98.30	28	59.33	CHANGED	hRl+......ssttGslspl+sLlpHsMEoGhRKDt.sGphlPscaIpplsspaNGcsVhsuphusulSpNPahpFphpuspsG..plplsWtDscGsshssptsl	...................lp......ttttGphhcl.+hllpHPM-oGhp+Dt..s.sphI...........PspaIppls.s.p.h.s.....G....p........V.h.ssphssulScNPhhpFphpsstsG..plplsapDscGsshssph...........	0	44	121	159
+8604	PF08771	Rapamycin_bind		Rapamycin binding domain	Mistry J	anon	pdb_1aue	Domain	This domain forms an alpha helical structure and binds to rapamycin [1].	20.40	20.40	20.40	21.30	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.38	0.72	-3.92	38	401	2009-09-13 23:50:46	2006-05-09 16:26:34	6	35	280	10	270	412	16	98.30	52	4.38	CHANGED	ELIRlAlLWaEhWa-uLE-.ASRhaF....s-cNhctMhssLpPLH-hLc+.sP-TlpEsuFhpsaGccLpcApcalppYppopc.hssLspAWclYapVF++Is+Q	...........................ELIRVAlLWHEhWHEGLEE.ASRLYF....G-+NlcuMapsLcPLHphL-+....GPp....T..L+Es..........SFs.........QuaGRDLtEAp-asppY..................pp..............o........ts.......ls-LsQAWDlYYpVFR+Is+Q..................	0	111	162	236
+8605	PF08772	NOB1_Zn_bind		Nin one binding (NOB1) Zn-ribbon like	Mistry J	anon	pdb_2con	Domain	This domain corresponds to a zinc ribbon and is found on the RNA binding protein NOB1 (Nin one binding).	22.00	22.00	22.00	22.40	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.72	0.72	-4.15	37	331	2012-10-03 10:42:43	2006-05-09 16:52:55	6	6	292	1	235	333	15	73.50	42	16.00	CHANGED	pI+pl+palLRC+ACaphsp....-hs+pFCPpCGss.TLp+Vulols..psGphplalppp.hphssRGspYSlPpPpuG	..........I+pl+salLRCHuCFpsTp.........chsKhFCP+CGst.TLp.+Vulols......csGphphHlppN.h.h...ssRGp+YSlPpPpuG.....................................	0	84	130	194
+8606	PF08773	CathepsinC_exc		Cathepsin C exclusion domain	Mistry J	anon	pdb_1k3b	Domain	Cathepsin C (dipeptidyl peptidase I) is the physiological activator of a group of serine proteases.  This domain corresponds to the exclusion domain whose structure excludes the approach of a polypeptide apart from its termini.  It forms an enclosed beta barrel structure composed from 8 anti-parallel beta strands [1]. Based on a structural comparison and interaction data, it is suggested that the exclusion domain originates from a metallo-protease inhibitor [1].	20.20	20.20	20.80	20.50	19.10	19.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.78	0.71	-3.93	10	167	2009-01-15 18:05:59	2006-05-09 17:23:39	6	6	78	5	92	178	1	106.90	39	23.58	CHANGED	DTPANCTY-DLlGTWlFpVucts....cpslsCSphssscpolsVsLpcLslAsD-aGNpGaFTLIYNQGFElslNcYKWFuFFKYcppGopVhSYCccThPGWVHDlLGRNWACFsupKl	.........................................DTPAsCsa.-.lhGsWhhphu..t.................tp.ppl.sC..............s........t....s.....s....p..pph..h...lpLp..p.shAh......D.p........h...G.N..s..GpaTlIYNQG..FElsl.....Ns.....hK......aFAFFK.....Y...c..p...c..G....p...p......s.h..S..h.CpcThs..G..W.s........+..D..h......hs..ppa.uCahupK.................................................	0	42	50	67
+8607	PF08774	VRR_NUC		VRR-NUC domain	Iyer, L, Bateman A	anon	Iyer L	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.47	0.72	-3.98	77	1394	2012-10-11 20:44:44	2006-05-09 18:51:10	6	14	1169	0	380	1233	264	99.00	21	24.30	CHANGED	hpctphpstlhpthp.phs........hhhhhhthuh......................h..........uh.sGhPDlllh........hsssp........................hhhlElKuPs.......s+lpcpQhphh.ctltpp.....GhpstVspstp	..................................................................p..hhp.hp.phs...........h.hh.hu.........................................................h.th..............uttsGhPDhll..h..................hspsp...................................................................hhhlElKuss.................s+lpst.....Qhp....hh.chlppt.....GhtVtVsps...........................	0	109	224	308
+8608	PF08775	ParB		ParB family	Mistry J	anon	pdb_1zx4	Domain	ParB is a component of the par system which mediates accurate DNA partition during cell division.  It recognises A-box and B-box DNA motifs.  ParB forms an asymmetric dimer with 2 extended helix-turn-helix (HTH) motifs that bind to A-boxes.  The HTH motifs emanate from a beta sheet coiled coil DNA binding module [1]. Both DNA binding elements are free to rotate around a flexible linker, this enables them to bind to complex arrays of A- and B-box elements on adjacent DNA arms of the looped partition site [1].	25.00	25.00	28.10	27.70	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.64	0.71	-3.82	15	218	2009-01-15 18:05:59	2006-05-10 09:43:09	5	6	166	4	18	138	1	123.10	38	38.43	CHANGED	FPVts-LoauDYphLh+lpcphpppphslspllpslppclcslps..phs.--tKspIhchIppchptlpstss+cps.plssLtpF-sKcpFARK+s..KGRphoYEFuRlsp-lQccL...DpAIcplLcc	...FPVts-LohoDYphLhclsEchppcsh.ol-pllpslpp..clpsl.s..ths.--tKspILclIppps.phLts.ssKsp....ssstLhpFc-KcpFARK+s..KGRtlsYEFuRlSp-lQcEl...DcuIpclLc.......	0	1	4	14
+8609	PF08776	VASP_tetra		VASP tetramerisation domain	Mistry J	anon	pdb_1usd	Domain	Vasodilator-stimulated phosphoprotein (VASP) is an actin cytoskeletal regulatory protein.  This region corresponds to the tetramerisation domain which forms a right handed alpha helical coiled coil structure [1].	20.70	20.70	20.70	20.90	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.97	0.72	-4.64	6	249	2009-01-15 18:05:59	2006-05-10 11:43:15	6	5	71	2	102	217	0	39.40	58	7.98	CHANGED	-uhDhDRhKQEILEEVhRELpKVKEEII-A...hpQELp+huo	.......-uhDhDRhKQEIL-EhR+ELpKlKEEIIDA....IRQELu+.so.......	0	16	26	55
+8610	PF08777	RRM_3		RNA binding motif	Mistry J	anon	pdb_1owx	Domain	This domain is found in protein La which functions as an RNA chaperone during RNA polymerase III transcription, and can also stimulate translation initiation. It contains a five stranded beta sheet which forms an atypical RNA recognition motif [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.29	0.72	-4.18	15	306	2012-10-02 20:46:34	2006-05-10 12:05:32	6	12	140	1	190	739	8	99.90	29	22.53	CHANGED	GsllchoG.lscsso.R-clKshFppau...cVtaVDapcGsppGtlRFcssps..AccAhcpss-u....pl.l+ctplsh-lLpG-cEccYhpKIlpcpppph..sp.+pKGR	........................Gsllchp....sc...ss....Rccl+phhs.p.hu...........clt....a.l......D.a......h.....c.......G.s.p......c.......G......h......lR......Fcpsps..Apcsl.pphpp...s....................t........h.h.....c....s.....p.p......h.......phcl.Lp..G...-tEccah....pK....Iht.....c.pppph...sp.+p+t............................................	0	63	85	134
+8611	PF08778	HIF-1a_CTAD		HIF-1 alpha C terminal transactivation domain	Mistry J	anon	pdb_1l3e	Domain	Hypoxia inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the heterodimeric transcription factor HIF-1.  It plays a key role in cellular response to low oxygen tension. This region corresponds to the C terminal transactivation domain.	25.00	25.00	26.80	27.50	23.50	22.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.75	0.72	-4.49	15	244	2009-01-15 18:05:59	2006-05-10 13:04:30	5	11	100	5	63	202	0	38.70	68	4.98	CHANGED	hsshsLP...QLTRYDCEVNAPlpGpppLLQGEELLRALDQVs	......h-p.sLP...QLTpYDCEVNAPlQ..GspsLLQGcELLRALDQss...	0	5	14	28
+8612	PF08779	SARS_X4		SARS coronavirus X4 like	Mistry J	anon	pdb_1yo4	Domain	The structure of the coronavirus X4 protein (also known as 7a and U122) shows similarities to the immunoglobulin like fold and suggests a binding activity to integrin I domains [1].  In SARS-CoV- infected cells, the X4 protein is expressed and retained intra-cellularly within the Golgi network [2].  X4 has been implicated to function during the replication cycle of SARS-CoV [3].	20.40	20.40	20.60	124.50	19.30	15.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.09	0.72	-3.82	2	79	2009-09-11 12:31:16	2006-05-10 13:19:27	5	1	75	2	0	18	0	83.90	97	68.92	CHANGED	ELYHYQECVRGTTVLLKEPCPSGTYEGNSPFt.PhhsNtahl......hsFspssGoR+T.YQ.hscp.os+hF.h..phQ.chas	ELYHYQECVRGTTVLLKEPCPSGTYEGNSPFH.PLADNKFALTCTSTHFAFACADGTRHT.YQLRARSVSPKLFIRQEEVQQELYS........	1	0	0	0
+8613	PF08780	NTase_sub_bind		Nucleotidyltransferase substrate binding protein like	Mistry J	anon	pdb_1wwp	Domain	Nucleotidyltransferases (EC 2.7.7) comprise a large enzyme family with diverse roles in polynucleotide synthesis and modification. This domain is structurally related to kanamycin nucleotidyltransferase (KNTase) and forms a complex with HI0073, a sequence homolog of the nucleotide-binding domain of this nucleotidyltransferase superfamily [1].	25.70	25.70	25.80	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.64	0.71	-4.35	40	469	2012-10-01 22:14:54	2006-05-10 14:57:29	6	5	340	14	148	413	71	119.10	30	86.46	CHANGED	p+hssap+AltpLcculph...........p.hs-l.psGlIQpFEaTaELuWKhhKcaLch.pGh..plh.us...RsshRpAhptGLI...sDs-h.WhchlcsRNhTSHTYscchAcclhppIh.pYhsthppLhpplpp	..........................................................chpshppAlppLpcuhp....................p..schhhsGhIQ+FEaoaELuWKhhKchLph.pGh.....phh..us....+sslR.pAaptGLI...p-t..ch..WhphlcsR.NhTuHoY.sc..phA..p..plhppIh....pahs.hppLhpplp.........................	0	58	106	125
+8614	PF08781	DP		Transcription factor DP	Mistry J	anon	pdb_2aze	Domain	DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression.  The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [2] and negatively regulates the G1-S transition.	20.90	20.90	21.00	21.00	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.69	0.71	-4.51	24	312	2009-01-15 18:05:59	2006-05-10 16:38:45	5	6	136	1	166	279	7	135.20	48	35.77	CHANGED	p-sppLchE+pc.thcRIcpKps.LpELl.QplAhcsLlpRNpphEpp.sssPs..osIpLPFIllpTsp+ssl-spISsDppchhFsFsso.FE.IHDDhpVLKpMuhshulcsstssspshphspohss....................hslpshlsthspspttp	....................................QEspsLEhE+p+.RhERI+pKpupLQELl.....lQplAFKNL.VQRN+psEpp..sptPss......sosIpLPFIllNTu++TlI-C.SISsDKhEYlFsFDs....T.FE.IHDDlEVLK+................MGhuhGL...-sGpCo.c.slphu+ohlP.....................psLp.Ylpth.t.....s...........................................................	0	54	85	121
+8615	PF08782	c-SKI_SMAD_bind		c-SKI Smad4 binding domain	Mistry J	anon	pdb_1mr1	Domain	c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins [1].  This domain binds to Smad4 [2]	25.00	25.00	25.80	30.30	24.60	18.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.42	0.72	-3.87	7	320	2009-01-15 18:05:59	2006-05-10 16:54:37	5	4	90	2	180	285	0	92.80	47	15.16	CHANGED	SF+VYHECFG+C+GLFlPELYsuPsAuCIQCh-CRhMFsPpKFVsHSH+s.E.pRTCHWGF-SuNWRuYlhLspcYts+-cpupLpplL--lKtKFc	............uFcVhHEChhtC+GhFl.PphYsu.scAtCIpCh...Cshh.FoPpKFlhHSHR..s..s.....-..+......h.T...p..uhs.ssWRpaL..cLs........s.c.st..ppc.Ltphh--lKthFs.............................	0	38	54	115
+8616	PF08783	DWNN		DWNN domain	Mistry J	anon	pdb_2c7h	Domain	DWNN is a ubiquitin like domain found at the N terminus of the RBBP6 family of splicing-associated proteins [1].  The DWNN domain is independently expressed in higher vertebrates so it may function as a novel ubiquitin-like modifier of other proteins [1].	21.70	21.70	22.30	21.70	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.41	0.72	-4.04	26	408	2012-10-03 10:59:06	2006-05-10 17:03:34	6	14	265	1	270	417	1	72.60	46	11.02	CHANGED	laYKF+.Sp+c.hsplsFDGo.sIoVhDLK+cIlppp+LGcupD......F-LplhNspTpE.....E.Yp.DDstlIP+sooVll+RlP	....VaYKFp.Sph.s..asslsFDGh.tISVt-LK+pIhppc+Ls.cupD..........hDLpIpNupT.pE...........E.Ys.DDsslIP+soSVIlRRlP......................	1	80	164	220
+8617	PF08784	RPA_C		Replication protein A C terminal	Mistry J	anon	pdb_1z1d	Domain	This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A).  RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.39	0.72	-3.60	23	349	2012-10-04 14:01:12	2006-05-11 10:35:05	6	5	269	16	223	404	8	100.20	20	37.20	CHANGED	Hhhho+spstssuu...........sssssssuhsss.........ushsussspshs......u.hsshpppVLshl+p..tstsscGlphc-ls.ppL..phssscl+pAl-hLss-GpIYSTlD-p	........................................................................................tt.................s....s...st..ss.hs..ss...........ssh.s.sss.t..shs..........s.hsshp.ppVhshl+s......stsp-....G...lphpplt..ppl.......ph..........s.hs...plppul-hLhspG.hIYoTlD-p.......	0	67	119	185
+8618	PF08785	Ku_PK_bind		Ku C terminal domain like	Mistry J	anon	pdb_1q2z	Domain	The non-homologous end joining (NHEJ) pathway is one method by which double stranded breaks in chromosomal DNA are repaired.  Ku is a component of a multi-protein complex that is involved in the NHEJ.  Ku has affinity for DNA ends and recruits the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).  This domain is found at the C terminal of Ku which binds to DNA-PKcs [1].	21.30	21.30	21.40	21.40	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.34	0.71	-10.58	0.71	-4.21	9	263	2009-01-15 18:05:59	2006-05-11 11:19:19	6	10	204	3	172	270	0	117.30	26	17.18	CHANGED	GolNPspDFpsLlpp+sts..hpcAhsQhpp+IhpLlpss.psp.apKulpClhAhRctslh.upscpFNsFLppLpphhps+pLpcFWp.llsp........cploLIopsEupsSsVosEEAppFLs...ppE	................................sPht-Fc.t.hl.........p.........p.........p.......css.........hpc..............AspQhtshIpphlpss....tss...at+..u..h-sltshRcpslphp.E.........sphaNsFl.ppL+c....pl...........p....c....p.....h........p........cFW.p.hl.hp........p.plsL.Isp..pEsp....s......Sp.V...otc-A.p.p.Fh....t...........................	0	62	96	135
+8619	PF08786	DUF1795		Domain of unknown function (DUF1795)	Mistry J	anon	pdb_1tu1	Domain	This is a bacterial domain of unknown function.  It forms an antiparallel beta sheet structure and contains some alpha helical regions.	20.90	20.90	21.00	21.20	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.42	0.71	-4.30	39	1088	2009-01-15 18:05:59	2006-05-11 11:40:40	6	4	617	4	112	378	4	129.40	29	78.06	CHANGED	EGshsLPss.apDcolNlhhhsssts..shollloRssltsucslpsalpcplptl.pppLptaphhs......ppssplusp....suhplp.........hpap.ppsp.laQhQshhhhs.........pplLhhThTs..ssshssppcttatsllsSh	...........................................hshsL.P..us..hpD.......p.......S...............Nh...hVhoDstsp..psslVIst-.hs.s......-.sLsshsp+hh.sp..cs+.sphplhs......scslpLtsp.......h.pLD.............shhs...upsp.psa..p....shllh.ls.........splLshphTh..sss.ppptpsp.hpslIpoh...........................	0	8	30	70
+8620	PF08787	Alginate_lyase2		Alginate lyase	Mistry J	anon	pdb_1uai	Domain	Alginate lyases are enzymes that degrade the linear polysaccharide alignate.\	\	They cleave the glycosidic linkage of alignate through a beta-elimination reaction.  This family forms an all beta fold and is different to all alpha fold of Pfam:PF05426.	25.50	25.50	25.60	28.80	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-12.01	0.70	-4.71	70	350	2009-01-15 18:05:59	2006-05-11 13:04:19	6	15	175	10	153	347	22	224.10	25	77.76	CHANGED	hDL...opWplslPh............ts....psspltspplts...saps..........haahssspus..hsFhsssp.....u....oossophsRoELREhh................s.sttsWshssss............phpAolpVspVsss............VlluQIHutp..............spPlh+lhap......ppG...........slhhthc................stttshthshhs...................sltLG.........ctFsaplp...lsss.....plplshsup....sptsh.....................................tsasspt..hYFKAGsYsQ...ssstsst.......................shupspFhpLpl.s+	......................................................hslspWplplPh................ts.stplpsspl.s......saps..........haahssstss..lhFhs..sss.....us...sTtsupasRoELREth................s.p.tsWhhssss..p...............phpuslpVsplsss.t..........llluQIHutp.............sspPlh+l.at......psG...................slhhthc.................ssststthslhs....................sl.Ls.........cpF.saplp...lssu.....pl.sVphssp.....sttph.....................................tsassp...hYFKAGsYsQ...ssss.st.......................phucspahpLplt..............................	0	22	98	137
+8621	PF08788	NHR2		NHR2 domain like	Mistry J	anon	pdb_1wq6	Domain	The NHR2 (Nervy homology 2) domain is found in the ETO protein where it mediates oligomerisation and protein-protein interactions.  It forms an alpha-helical tetramer [1].	20.10	20.10	20.10	23.90	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.45	0.72	-4.49	5	245	2009-01-15 18:05:59	2006-05-11 13:49:28	6	7	68	2	108	216	0	64.00	71	11.19	CHANGED	pEEslDHRLT-REWA-EW+H..LDphLNCIMDMVEKTRRSloVL.RRCQEuDREELNYWtRRaSDuEEs+	...............QEEhlDHRLT-REWAEEWKH..LDpl.......LNCIMDMVEKTRRSLTVL..RRCQEADREELNaWhRRYS-sE-h+...............	1	13	21	55
+8622	PF08789	PBCV_basic_adap		PBCV-specific basic adaptor domain	Iyer L	anon	Iyer L	Domain	The small PBCV-specific basic adaptor domain is found fused to S/T protein kinases and the 2-Cysteine domain [1].	20.40	20.40	20.50	20.50	20.30	19.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.93	0.72	-4.29	24	80	2009-01-15 18:05:59	2006-05-11 14:12:19	5	8	13	0	5	80	1	37.90	44	19.68	CHANGED	TG+lsuKGRtlacss+GtpYVhssu.KKVhVpchhpPpts	....TGKlsAKtRcVF+ssKG+sa.Vhps.s....KKVYVKKlhsPKt.....	0	0	2	4
+8623	PF08790	zf-LYAR		LYAR-type C2HC zinc finger 	Mistry J	anon	pdb_1wjv	Domain	This C2HC zinc finger is found in LYAR proteins such as Swiss:Q08288 which are involved in cell growth regulation.	20.70	20.70	20.70	22.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.22	0.72	-7.50	0.72	-4.24	30	311	2009-01-15 18:05:59	2006-05-11 14:27:46	6	11	250	1	203	291	3	27.80	55	8.36	CHANGED	aoCIDCspsF.stpsa+sHouCITEsEKY	..hoCIDCspsF..GssY+sHopCIoEspKY....	1	70	114	167
+8625	PF08792	A2L_zn_ribbon		A2L zinc ribbon domain	Iyer L	anon	Iyer L	Domain	This zinc ribbon domain is found associated with some viral A2L transcription factors [1].	22.90	22.90	22.90	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.84	0.72	-4.40	14	90	2012-10-03 10:42:43	2006-05-11 14:40:21	5	3	78	0	7	72	3	32.30	41	12.11	CHANGED	pp.phCph..Cspstlh...pppshhhCh.Csssh.h	......sl+hCss..Cppss..ll...o-puYchClhCpslaph...	0	2	7	7
+8626	PF08793	2C_adapt		2-cysteine adaptor domain	Iyer L	anon	Iyer L	Domain	The virus-specific 2-cysteine adaptor domain is found fused to OTU/A20-like peptidases and S/T protein kinases.  The domain associations of these proteins indicate that they might function as viral adaptors connecting the kinases and OTU/A20 peptidases to specific targets [1].	20.10	20.10	20.10	20.10	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.65	0.72	-4.07	38	112	2009-01-15 18:05:59	2006-05-11 14:53:58	5	10	28	0	2	116	7	36.90	36	19.63	CHANGED	ppCpcF....pcsPs.hNPhTG+sI+hsGPsY+clhccCsss	.......hCpcF....pcsPs.hNPhTGRsI+tsGPsactLtccCss....	1	2	2	2
+8627	PF08794	Lipoprot_C		Lipoprotein GNA1870 C terminal like	Mistry J	anon	pdb_1ys5	Domain	GNA1870 is a surface exposed lipoprotein in Neisseria meningitidis that and is a potent antigen of Meningococcus.  The structure of the C terminal domain consists of an anti-parallel beta barrel overlaid by a short alpha helical region [1].	25.80	25.80	26.50	26.30	24.80	25.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.00	0.71	-4.36	2	580	2009-01-15 18:05:59	2006-05-11 14:54:44	5	2	98	13	6	555	0	148.80	63	58.36	CHANGED	QsHSAlsALphEplpss-+.sphlspRpFhluDluGEHTuFspLP-.G+ApY+GpAFuSDDAsGKLTYTIDFAAKQGHGKIEHLKoPE.NV-LAuu-lKsDcKpHAVI.GsshYsttEKGoYpLulFGspAQElAGSApVchuptl+cIGlAsKQ	......................................QsHSAlsALQhEp.lpss-+ssp.h..lspRp.Ftlu-IuGEHTuFspLPcsG+AsY+GpAF.....u..S.........D....D.........A.........G......G.......KLTYTIDFAAKQGaGKI...EHL.K.o...PEh.N...V...-LAu...A-............l.........Ks............D......EK....p..HAV.......I...SGs..s..hY.s....p.......s..E....KGoYpLulFGs+AQElAGSApVK..hsptl+cIGlAuKQ................................	0	1	2	4
+8628	PF08795	DUF1796		Putative papain-like cysteine peptidase (DUF1796)	Iyer L	anon	Iyer L	Domain	\N	21.60	21.60	24.50	24.30	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.09	0.71	-4.62	26	236	2009-01-15 18:05:59	2006-05-11 14:56:26	5	2	163	0	42	187	9	161.00	29	64.13	CHANGED	hsthlSLGutCtsAhhLpKhsLR..shuhPFDahhs.olssltchlpscFsshhp.pth........................................t............h..pshhtallacshauh.sha-apss..s..s......chhtchp+Rhcphhpplpssp..........plhFlR.....ssh.shctlh-hhphltptsss.pshhlll.htppsts	...................pslhSLGppChsAhtLpph.pLc......shuushDahh....Sso...Lpp...Vs...pLLpNc.FscFhphpsl...............................................................p...............thh.psssphhl..cDshYsl.ohHDFtsshss.psh..........tY.ch+tphc+RlsRFlpplpssc..........slLFlR.....tss.s.h-EshpLpplLsphspp.phplLll........ss.......................................................	0	9	24	32
+8629	PF08796	DUF1797		Protein of unknown function (DUF1797)	Mistry J	anon	pdb_2ffg	Family	This is a domain of unknown function.  It forms a central anti-parallel beta sheet with flanking alpha helical regions.	21.40	21.40	22.80	39.90	21.10	18.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.19	0.72	-4.10	17	675	2009-01-15 18:05:59	2006-05-11 15:37:50	5	1	670	2	59	161	0	68.10	54	86.93	CHANGED	IIsRLcuMtcst..suEsppRpFE+pG..hspVsasppsc...sapLcchpsccp...apFDsIDLlAIEIaDLL	..................IIsRLEAMtp....DGtshpRpFER-GVslspVuasccpE...hFpLc-scs+Eo...YpFDsIDLlAMEIY-LL.	0	11	31	45
+8630	PF08797	HIRAN		HIRAN domain	Iyer L	anon	Iyer L	Domain	The HIRAN domain (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p. The HIRAN domain is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes [1]. It has been predicted that this domain functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks [1]	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.27	0.72	-4.12	51	781	2009-09-10 22:04:53	2006-05-11 16:15:26	6	29	554	5	366	662	33	100.50	19	15.98	CHANGED	hGshpsps.......huhph......................hhphlph....uptlhlpRpsps.............................................hDpsA....................lpVtsss......ut............plGalPcchuphlus.Ll-pt...hhphcuhlh.........ssp....tthsh.pplhlhhpsh	.......................................................................hth.......huhph...........................h.t.lp........uph..l.tlpREs.sNs............................................aDps.A.............................l+..V....sss.......st.............plGalscphAthlus.hhDpt....hhphpu.h.l......................................t....................................................	0	103	231	304
+8631	PF08798	CRISPR_assoc		CRISPR associated protein	Mistry J	anon	pdb_1wj9	Domain	This domain forms an anti-parallel beta strand structure with flanking alpha helical regions.	25.00	25.00	27.40	25.90	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.19	0.70	-4.58	50	667	2012-10-01 21:23:39	2006-05-11 16:20:22	6	2	628	14	132	457	17	206.90	36	97.62	CHANGED	MYLS+lhLssppttstp...........hsssYshHphlhphFss.......t.ssptphLaRlE...........pttstsplLl.SsppPchst................sshshpscshhspLpsGpphpF+LpANPstpt.........................t.ttpup...chshhppp.pthpWLp..++upptGFplhs.............................hhphpshppcphpppp...........p.lphssVsF-GhLpVsDssthhpsLppGIG+uKAaGCGLLolss	......................................................................................................MYLSRlpLcs.sp...h....pstph............ps.YshHphLasLFPs............................spc+pFLaRhE..............phpsshphhllSpppPsto.......................shhslps+sF.hsp.LpsGppLpFpLRANPshsp.............................................................h..ptp.t.phc....sp.s.cup......cl.h...hhppp..stlsWLt...ppu-ps..G.F.sLhc.................................................ssVcu.hcpp..p.hc+cp..........ppphlphuoVcasGhLs.VsDP..s...hFhppLspGhG+u+AFGCGLhhltP.....................................	0	39	99	117
+8632	PF08799	PRP4		pre-mRNA processing factor 4 (PRP4) like	Mistry J	anon	pdb_1mzw	Domain	This small domain is found on PRP4 ribonuleoproteins.  PRP4 is a U4/U6 small nuclear ribonucleoprotein that is involved in pre-mRNA processing.	25.00	25.00	25.10	25.20	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.24	0.72	-4.67	61	535	2009-01-15 18:05:59	2006-05-11 16:32:06	6	15	264	2	398	508	1	29.90	51	6.74	CHANGED	Vhp+LRplsEPIsLFGEsct-RpcRL+plh	...Vhp+LRplGEPIsLFGEsst-RhcRLRpl......	0	135	213	321
+8633	PF08800	VirE_N		VirE N-terminal domain	Bateman A	anon	PSI2 target AAO76744.1	Domain	This presumed domain is found at the N-terminus of VirE proteins.	20.60	20.60	21.30	21.50	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.43	0.71	-4.41	14	419	2012-10-02 15:26:12	2006-05-11 17:59:31	5	13	90	0	49	404	58	131.70	27	24.52	CHANGED	-tpphtcp.LPtlhsuutacc..tcstpphptasGllhl-lc+Ls..pchstl+pphtthP.T..hhAFhusSG+uVKIhlhhst.-ss.h.t........p.tp...ap....utAYphssphYpthl...shsl-hps.slsphChhoaDP-sYa	.............................tphKpp.LPhlsPuupFpc...cstpphtpasGllhlDlDcLs..sh.....p...E.h...tpl+p..ph..hp..tP...ts......hhsFhosSGcGVKlhl.....hh.s.h....s....sss..h............t........ap....tpuY.ph.ss..p..h..ap.hh......sh...plDh.p...s...t..slsRhCh.loaDPcsaa......................................	0	20	45	49
+8634	PF08801	Nucleoporin_N	Nup133_N;	Nup133 N terminal like	Mistry J	anon	pdb_1xks	Domain	Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure [1]. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.	23.70	23.70	23.70	23.80	23.60	23.50	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.45	0.70	-5.73	57	599	2012-10-05 17:30:43	2006-05-12 09:01:07	6	12	283	1	388	605	4	407.80	16	33.61	CHANGED	sp.stapshphhs.hPstlhpphsps...........................p..spsuhhschshuhhsscsclhlWs.Y..................................t.ssph.h........................h.st.ppslsul..........sl.VpPps..G..hahpslsahhslusshp......lhlhh.........................lhssphssphhsspsss.hlhssssGRlhhhuhps..sh.pl..ph.pt.ps.......psst.shstsuh.usl....hss..........................................tt.cs.lsplpssppc.....phlashoscuhlphaplp.....sspthpp.......lhphhtpth.pth.......................................s.....phcllclpslstp.....................psthhhLluhspsusph.hthh.h......................................h...h...........................................p..hh.ss......h.t.phps......thhs.tlalsssspps...................................hlhssssshs..................hhp...pt...........hEsshhhp.s..................................hss..uhpp..............p.p.....ps.p.hhlhpstGlhh	.......................................................................................................h...ph.s.lPstlhc..thsth...........................pstphhul.h.sphshAWlshcsclhlWsY...........................................p.stph.h.............................h..ss.spsl.uV...............sl.ltsps..G..hahss.lp...ahhs.lssshp.......h.l.s.....................................................................lhssthh.....s..h.hsss..sts..h..lhuossG.Rlhh.........hs.h.s.s.........slapl.......th..pttps.......................phpthshst.uu.l.u.l......hss......................................................................st.cs..lspl...th-..ps+........phlaslospu.hlp..haclp.....sspthtt.......lhp.h.pst.hhtth.................................................s.t.p.phpllsl...p..slsss......................ts...h.htLlu....h...s.ps.uh.phahshssh.........................................................t.h.h..h..............................................th.s..s..............s....p.pt.......hhs..t.hhl.hh.s.pps....................................hhhhsssshs.....................t........................-.shhhht........................................................................................................s.t.hhhhps.Gh.......................................................................................................................................................................................................................................................................................	0	119	200	315
+8635	PF08802	CytB6-F_Fe-S		Cytochrome B6-F complex Fe-S subunit 	Mistry J	anon	pdb_1q90	Domain	The cytochrome B6-F complex mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.  This domain corresponds to the alpha helical transmembrane domain of the cytochrome B6-F complex iron-sulphur subunit.	23.30	23.30	23.50	23.80	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.69	0.72	-3.95	19	215	2009-01-15 18:05:59	2006-05-12 09:15:23	5	3	170	9	83	203	111	37.50	46	19.78	CHANGED	D.VPDMu+RplhNLLhhGulussssuhLhPhspaFlPPu	.....VPDMuRRQhMNL.LhhGslohsAsGhLhPhspaFlPPt....	0	20	54	73
+8636	PF08803	ydhR		Putative mono-oxygenase ydhR	Mistry J	anon	pdb_2asy	Family	ydhR is a homodimeric protein that comprises of a central four-stranded beta sheet and four surrounding alpha helices [1].  It shows structural homology to the ActVA-Orf6 and YgiN proteins which indicates it could be a mono-oxygenase.	27.10	27.10	27.20	28.40	26.60	27.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.19	0.72	-3.91	23	612	2009-01-15 18:05:59	2006-05-12 10:05:35	6	2	606	6	47	201	70	96.50	66	94.04	CHANGED	LLQlDFsasGP.FG--hupuhpsLAcSIspEPGhIWKIWTENppspcAGGIYLF-scsuApsYLpMH.oARLpsh.Glsclpu+lFDlNpsLopIs+uPl	...............LLQlHFsFsGP.FG.-tMscQLp..sLAESINpEPGFlWKl......WTESEKN+EAGGIYLFp-EcoA..A.YLEKH..TARL.KsL.GV-EVsuKlF-VNEsLopINpupL...................	0	11	28	37
+8637	PF08804	gp32		gp32 DNA binding protein like	Mistry J	anon	pdb_1gpc	Domain	gp32 is a single stranded (ss) DNA binding protein in bacteriophage T4 that is essential for DNA replication, recombination and repair. The ssDNA binding cleft of gp32 comprises regions from three structural subdomains [1].	20.10	20.10	20.90	22.50	19.60	19.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.26	0.72	-3.87	10	98	2009-01-15 18:05:59	2006-05-12 11:05:39	5	1	90	4	0	87	390	82.80	51	31.51	CHANGED	DccEWKLchDsuGNGpAVIRFLPuKs-Es.LPFVKLlNHuFKcNGp.WYIENCsSTHGDaDsCPVCpahpps-L.a.....Noss-ctphhup.hKRKtSYW	............Dcp.WKLchDsu.GN.GpAVIRFL..P.......u...........s....t-p........hPasplhsHuF+ts....Gt.WYIENs..oThGc..ssPVspa..ppcL.a.....Nsspc..p...p........KRKhuaa..........................	1	0	0	0
+8638	PF08805	PilS		PilS N terminal	Mistry J	anon	pdb_1q5f	Domain	Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells.  In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator [1].  Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus [2].	20.80	20.80	20.80	20.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.73	0.71	-4.64	18	332	2012-10-03 10:38:27	2006-05-12 11:51:41	6	3	257	5	49	317	16	137.50	30	72.62	CHANGED	sscsssEpsNlsslhsss+u.hKus.uuYs...uushsssLlphtulPssMss..sGs......slhNsWGGsVTVsss.....usst.oFolThssVPpssClsLsTplusu...hsshsIsus......shssu..plssssAs....osCsus.....sNTlsaTos	........................................................................tpstpEtsNlpsIhsss+u.hh.pus.suYs.......suphsssLlp.hsshP..ss.Mhs....sus..........slhNuW.GG.s.VT.luss.........usss..uFTlT...h...s...sVPpcsClpluT.t.huss.....htsh...s...lsus..................sh.su.........lssssAu......ssCsss.....sNolsaT............................................	0	13	27	37
+8639	PF08806	Sep15_SelM		Sep15/SelM redox domain	Mistry J	anon	pdb_2a4h	Domain	Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif [1].  This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum [1].	21.20	21.20	21.40	21.70	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.43	0.72	-4.23	12	179	2009-01-15 18:05:59	2006-05-12 13:10:50	6	2	121	2	112	204	1	73.00	33	48.92	CHANGED	putl.pssGU+LsphPcVctFlpsDh...sha.sLphKalhGucP.lhLhDcpsp.hEc.lslschspDclpphltp+shh	.............................s.ttl.ps..sh..p....p..h.sthPp...l.puFlpp-h...tha...slplKalhGuc.PhLhLLD.c.pGp..tEp...lsl.pcW.sp-plppalpp+hh...............	0	44	62	91
+8640	PF08807	DUF1798		Bacterial domain of unknown function (DUF1798)	Mistry J	anon	pdb_2ets	Domain	This domain is found in many hypothetical proteins.  The structure of one of the proteins in this family has been solved and it adopts an all alpha helical fold.	25.00	25.00	40.00	65.50	21.00	19.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.43	0.72	-4.35	19	391	2009-01-15 18:05:59	2006-05-12 13:39:28	5	1	391	5	32	144	0	109.40	44	93.99	CHANGED	hTppLlptscchhp+Y.ps..+cpspcaDFappVKPas-chcphlcpWpphAhpalppt+PcYl+tpQl-tsh-Nhpplslpuaas+spcKRFh-hhcSlpYsLphlh-tlt.p	.......s.sEpLl.cssphpppapps..Kpptp-aDFYpsVKPas-clDshLschK.ht.hhIch....Yhsspph-hlhsNlppluVpCaap+os+KhFlE+hcSlpYsLQNIl-tlt.Kc...	0	8	18	26
+8641	PF08808	RES		RES domain	Bateman A	anon	PSI2 target CAE41587.1	Domain	This presumed domain contains 3 highly conserved polar groups that could form an active site. These are an arginine, glutamate and serine, hence the RES domain. The domain is found widely distributed in bacteria. The domain is about 150 residues in length.	20.50	20.50	20.80	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.51	0.71	-4.16	184	1322	2009-01-15 18:05:59	2006-05-12 14:02:02	6	8	874	0	452	1175	109	164.20	15	70.86	CHANGED	plaRlptt.............................ph.t..s.............s......s.Rass...........s.uhssl.Ysuts.....hssAlhEs.......................................hhhsthhhtththsshthttth....t........t.h....htshsshts.t............thspthsp...thtt.sh........................ulhhsS...sh................s.....s..stslslhsst............................tthphhpspththths	.................................................................................h...................................ph....s.........t.hh..hG..u.Rass..............t..shs.sl..Ysups.....hpsAlhEs.........................................................h.h..................................sthh...sthh...ht.th.t.hssh.h...thtph.......hph...............h..........h......th..ts.sh.tt..........................h.hspt...hup.......thp..sh..............................t.......GlhhsS......sh..............s......s.....shslslas.t.......................................................................................	1	115	273	368
+8642	PF08809	DUF1799		Phage related hypothetical protein (DUF1799)	Bateman A	anon	PSI2 target CAE43631.1	Domain	Members of this family are about 100 amino acids in length and are uncharacterised.	20.80	20.80	21.10	20.80	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.01	0.72	-4.18	15	119	2009-01-15 18:05:59	2006-05-12 14:06:48	6	3	110	0	32	116	31	77.20	31	69.89	CHANGED	LtthG..hp.-Da..c..psshEVWPEN.htAhplFtuhuTQWRs........GssGshGLDYusl.shhchhGlctEppp-lassl+lhEppALchl	...................h...................hplWP-s.h.uhplFhshuTQWRs..................Ghu.G.s.sGLDYusl.tlhchh.sl.p.scpp.tlhsclRlMEttALphh......................	0	2	17	26
+8643	PF08810	KapB		Kinase associated protein B	Mistry J	anon	pdb_1y71	Domain	This bacterial protein forms an anti-parallel beta sheet with an extending alpha helical region.	20.00	20.00	20.00	41.60	19.80	18.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.34	0.71	-4.03	10	347	2009-01-15 18:05:59	2006-05-12 14:14:48	5	1	347	2	28	126	0	112.60	61	88.34	CHANGED	YKTGsYhGpIpE-+spp..hLVcVcAVlKHPpQGDLHNPsQs.-ssFFHERKALuahEKphls+utV+sa-s.ElPsYs-SLppAlschcs+Lps-soc...aAppSLcsLcpL+c-Ytl	.HKTGsYuVsIsE-sss.s..lLVKVcQVIKHPKQGDLHNPsET.-sVFFHERKALSaaEKRaspcSpL+cFNs.-.lhcYEDSLQpAlocLEspL+tpp.oc...aAchSLsoLscLKcDYsL..	2	9	17	24
+8644	PF08811	DUF1800		Protein of unknown function (DUF1800)	Bateman A	anon	PSI2 target AAK23953.1	Family	This is a family of large bacterial proteins of unknown function.	25.00	25.00	26.60	26.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.46	0.70	-5.56	77	530	2009-01-15 18:05:59	2006-05-12 14:19:30	6	11	396	0	221	585	994	467.30	24	84.11	CHANGED	tphLsRhsaGsp...suplsphhp.h.......uhpsalppQl...............stsss..sshhtt.hsphs....................................................................................................................................................ttptttcpt..t........................................hh.t..tuhhtpAlhus.spLpERhshFWpNHFsVSspc...s.h.phhssshpp-slRsauhG.......pFc-LLtAlsppPAMhhYLDshps......................................s.t.......ctt...t.NENaARElhELaTLGl........................s..uG.....YoQpDVpphARshTGWslsstt..........................tsshahapsph........H-susKs...............lL..Gpshs.s..............sG.tcs..ptsL-hLspHPsT..ApFlup+Lhp+FVu.....Ds.PssuhVpRlApsFp...po..............cGDltAVlpslltssEhhss..........tsK.....l+sPhchhlushRshshp.sss..................................................tthhshlspLGQshatsso..........PsG......as.sssuWsuspthltRhphstpl..usthhsshh.............................sspshtt............hh.thhss...shospop.psltps.sttt................................hlslllsSPEF.hc	.....................................................................................................................................................................................................................hhLpRhsaGsp...ss..plsth...ht..h........shpthltt...l......................ts..t.....sshh.....tt...httht.......................................................................................................................................................................................t.ptthpp..........t....................................................................................................htphtt...th....lt..phlh..s..s.......s......tLpERh.shFWpsH.Fslutpp...s.h.ph.......hhh.hppphlRtpA.hG..................sFp-LLtAlspcPAMLhYLDstps..........................................................................................ppttsNENaARElMELaTLGl.......................ssG........YoppDVpphARshTGWshss......................................tstahapsp.h........H-sGsKs........................................lL.Gp..s.h.t................tG.tcsctsLchLhp..+..P....s..T..ApFlup+LhpcFVu.............-s....P...........s.........su.hV..p+lAssFp...ps....................sGDltsllpsllpsschhss....h...............ss+lKsPhchllushRshshs.sss...................................................t.h.hs...h.h.ppLGQ.shatsss.......................................PsG......a......s.........s.....s...suWlsssshltRhphsttl...sst.hhtt.h....................................................................................s.tth..t...............................................th.lts....t....hssps.t.tsltpt..st.p..........................................................................hhthlhhuP-a.h.....................................................................................................................................................	0	79	146	186
+8645	PF08812	YtxC		YtxC-like family	Bateman A	anon	PSI2 target YtxC B.subtilis	Family	This family includes proteins similar to B. subtilis YtxC an uncharacterised protein.	20.80	20.80	20.80	21.40	18.90	20.70	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.41	0.70	-4.84	33	299	2009-09-10 22:38:25	2006-05-12 14:27:35	6	1	295	0	79	225	0	214.20	31	73.96	CHANGED	hc.hhlusllschllpph-cchltclIpcsYhahcp-EpppIhch.uppILcs-ppth..pph.phs++s.Ihcclt-hlp-s.splsl-GFlsFRL+-YhccLcchl-pAl-EYhhE+EYpEFIcLL+aFV-hQcs+lctVallhs.stpahLaDcctcplss-hlpphhsc..lhppslsh-DlLISsLIolAPccIhlast-psc...phlpTIpsVFp-RVph	..............................................................pthlhsslsphIlp.hhppchlhpllpcpaa.ahc.p-EpppIhph..upplLcscppt...h......t....p.h.phs.............pc.shIhsplpsalp-s.....phshsuFlpFRL+sYhcplpcls-hAlDEYhhEpE...YppFIch....L+.aVc..pcs+lspV+llhc.p.sFhlaDccscclppc.pltphhcc..htppsl.h-..shlIusLloluPc+Ihlasc.cps.p.....phlpTlcsVFp-RVp.h....................................................	1	38	64	69
+8646	PF08813	Phage_tail_3		Phage tail protein	Bateman A	anon	PSI2 target CAE43633.1	Family	This family of proteins include phage tail proteins.  They probably include bacterial Ig-like domains related to Pfam:PF02368. Which also includes a number of phage tail invasin proteins.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.90	0.71	-4.85	12	222	2009-01-15 18:05:59	2006-05-12 14:32:47	6	3	207	0	34	177	8	149.50	24	74.81	CHANGED	SuWspLss+ss+ssssossshsl-GIDTocst.assG.Ghuphh.lsoWs-lspVpslupsGG-QQFhsaphLpD.D.+cpQIPThKSAhshThThAa-.shsaatsLcpAD-s+pshslRhplPsusph.hasuYhuFscsPohshNthhsholslSltuc.ThhAu	.........................................................................................h..h..s..sapcl.sp.lp..-lspsGu-tphlphshLpD...s..hp..p..phss...hps.Asshshsh..uac.s..s..p..s..s..ap.sLct.ss-scp.hhshchth.Ps.G..s....ps...hapuhlSh.c.....hs..ssssNtlhsholslslpu.c..shh..s.......................................................	0	3	13	27
+8647	PF08814	XisH		XisH protein	Bateman A	anon	PSI2 target ZP_00111899.1	Domain	The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required [1].	25.00	25.00	26.10	26.00	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.64	0.71	-4.16	8	139	2012-10-11 20:44:44	2006-05-12 14:41:39	5	2	37	2	44	187	1	116.50	41	95.22	CHANGED	MsAKDlaH-sVKsALhKDGWtITcDPLhl+hGc.sslaIDLuA-KlIAAE+pspKIAVElKSFlu.sSpIsDF+sALGQaIsYRhlLcsp-sERlLYLAlscssYcsFFppchsQhllpcpplpLllaDsEpEpIlQ	.................MsA+DlaHpsV+pAL.K-GWhITcDPhhlp.hst.hphhlDLuAE.......+..........llAAE+ptpKIAVElKSFlu..S.lp-hcpAl..GQal.Y+hhLpt.p..-P-RhLYLAlspshYpsaFpp.hhphhlpc.plpLllassppE.Ih.....................	0	11	31	44
+8648	PF08815	Nuc_rec_co-act		Nuclear receptor coactivator	Mistry J	anon	pdb_2c52	Domain	This region is found on eukaryotic nuclear receptor coactivators and forms an alpha helical structure.	19.80	19.80	19.90	19.80	19.60	17.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.48	0.72	-4.43	10	226	2009-01-15 18:05:59	2006-05-12 15:38:57	5	16	42	2	81	169	0	49.10	64	3.62	CHANGED	EGpsDE+ALL-QLsohLsstD..uLEEIDRALGIPcLVsQutsh-...-pF	...EGpsDE+ALLDQLhohLsspD....GLEEIDRALGI.P-LVs.Q..uQul-s..-tF......	0	4	9	30
+8649	PF08816	Ivy		Inhibitor of vertebrate lysozyme (Ivy)	Mistry J	anon	pdb_1gpq	Family	This bacterial family is a strong inhibitor of vertebrate lysozyme.	19.90	19.90	21.00	21.00	19.10	19.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.63	0.71	-4.12	17	506	2009-01-15 18:05:59	2006-05-12 15:59:04	6	2	482	7	45	183	8	116.00	56	74.15	CHANGED	Lsppssa+ssWppMlpupppLPpWlppstGous.PhpslshsGppYlVGshCKPHD.CuupphhVhautDccp...AaGlhVplspt..sshcsPocaAsapWLGpPscs........hpuhLpppLc.pcPN	.............................LAKucsTKAAFNQMVQGHK..LP..A....W.VMK.G.GThT....PAQTVTLGDETYQVMSACKPHD.CGSQRIAVhWSEKSsQ...MoGLF........SoID...EKTSQEKLTWLNVs...DALSID.GKTVLFAALTGSLE.NHPD............................	1	8	17	29
+8650	PF08817	YukD		WXG100 protein secretion system (Wss), protein YukD	Mistry J, Desvaux M, Burroughs AM, Iyer LM, Aravind L	anon	pdb_2bps	Family	The YukD protein family members participate in the formation of a translocon required for the secretion of WXG100 proteins (Pfam:PF06013) in monoderm bacteria, with the WXG100 protein secretion system (Wss). Like the cytoplasmic protein EsaC in Staphylococcus aureus, YukD was hypothesized to play a role of a chaperone. YukD adopts a ubiquitin-like fold [1]. Usually, ubiquitin covalently binds to protein and flags them for protein degradation, however conjugation assays have indicated that the classical YukD lacks the capacity for covalent bond formation with other proteins [1]. In contrast to the situation in firmicutes, YukD-like proteins in actinobacteria are often fused to a transporter involved in the ESAT-6/ESX/Wss secretion pathway [6,7]. Members of the YukD family are also associated in gene neighborhoods with other enzymatic members of the ubiquitin signaling and degradation pathway such as the E1, E2 and E3 trienzyme complex that catalyze ubiquitin transfer to substrates, and the JAB family metallopeptidases that are involved in its release [7]. This suggests that a subset of the YukD family in bacteria are conjugated and released from proteins as in the eukaryotic ubiquitin-mediated signaling and degradation pathway [7].	27.00	27.00	27.10	27.00	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.57	0.72	-3.42	54	869	2012-10-03 10:59:06	2006-05-12 16:23:53	5	3	548	2	159	472	11	79.60	27	25.86	CHANGED	shscVslph........sp....p.thDlsLPsplPlppllsslhphls..........hsshs...........tss....phpLs....tsGt..hLstspoLsptsVtDG-lLhlh	..............hscVTlth........sp.....p.phDlslPutlPlcsllstllchls..............hshh-.............sss.h..phplt....spGt..hLstspsLs-hslsDGDlLtL.......	0	48	107	141
+8651	PF08818	DUF1801		Domain of unknown function (DU1801)	Bateman A	anon	PSI2 target AAO81511.1	Domain	This large family of bacterial proteins is uncharacterised.  They contain a presumed domain about 110 amino acids in length.	27.20	27.20	27.20	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.52	0.72	-3.93	150	1704	2009-09-12 22:25:29	2006-05-15 11:59:35	6	10	1072	5	545	1425	322	100.10	20	67.93	CHANGED	tt+pthppL+pll.tpsssp....h.pcplpa.......uhPsath..ttp................hsthss..hKp..alulhh....hpss.hp.........c..tt.l......ptphs+shhphpph.p.cls....hphlpphlppslp	...............................hppthppl+pllhpsssp................l.pEpl..pa........shPsash.sup...............sllthps.......hKp....alulha........tpu..u.lp..........c..tphl.t........phpt.s+sh.chp.ph....p.pls.....hchlpphlptsh.t.................................	0	237	402	491
+8652	PF08819	DUF1802		Domain of unknown function (DUF1802)	Bateman A	anon	PSI2 target	Domain	The function of this family is unknown.  This region is found associated with a Pfam:PF04471 suggesting they could be part of a restriction modification system..	25.00	25.00	57.80	45.90	24.20	19.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.02	0.71	-4.66	27	227	2009-01-15 18:05:59	2006-05-15 13:54:39	6	3	145	0	55	187	29	162.40	53	84.40	CHANGED	hALKEWssslcALtpGcphlLlRKGGIpEt.p..F....psptppFlLaPTh.Hpps....ctl+scapshlpts..st.tscplplpuaAplsssh.lss....ptlppLpshaIWstctlp.pRhpa+spp.lhlLlLRla.LscPhplshssp.atGCpSWlsLsp.l..shpsspPVlsDppasphtppl	.........s.ALKEWuAAV+ALl-GRQoVLLRKGGItE+.R....F........cVAu+cFLLFPTVuHoHA..............ERVRPEH+DL.....LsPA....AADS..T..-E..s..VlLRAuA+VVAAlsVsR...PEu..L-AIEcLHIWTAESVRuDRLDFRPKH+LsVLVVpshsLsEP....Vc..lscpP-.YuGCp........SWVpLs......l...ssphutPVhs-sshschstc.h.............................	0	22	41	53
+8653	PF08820	DUF1803		Domain of unknown function (DUF1803)	Bateman A	anon	PSI2 target AAO81393.1	Domain	This small domain is found in one or two copies in proteins from bacteria. The function of this domain is unknown.	23.70	23.70	23.80	24.50	22.20	23.60	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.21	0.72	-4.28	14	715	2009-01-15 18:05:59	2006-05-15 15:21:35	5	2	417	0	49	356	0	91.70	36	69.98	CHANGED	lpsa.hphhpppPh......hhcLl.....pYhhca..sshlL+.l++cashpc+hDhhl-shlthGYIhp.Es++YpLshsl...........................................Dp-uhhath	...........h.p.h..phhpp.sh......hhsll.....cYhhcY..sshlL+.lK+phs.ppshDhhl-phlthGaIlp.Es++YpLshsh..............................s....................t..........................	1	5	11	29
+8654	PF08821	CGGC		CGGC domain	Bateman A	anon	PSI2 target AAB98576.1	Domain	This putative domain contains a quite highly conserved sequence of CGGC in its central region.  The domain has many conserved cysteines and histidines suggestive of a zinc binding function.	21.50	21.50	22.90	37.20	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.95	0.72	-3.97	31	185	2009-01-15 18:05:59	2006-05-16 15:44:05	6	2	147	0	77	174	5	106.50	31	88.27	CHANGED	KluIlpCppsp-..h.CsG....ssCFKuhpp+puuFppap.p..sElluFhsCGGCs.........ucclhppscphh.cpss-....slHLuoChhts.............CPp..hcphpchlppch..sl.pVltGTH	.....KluIltCppsps..h..CsG....ssCh+uhpp+puuFppYsp.c.h-lluFhsCGGCs.........upplh....p......pscph......h...cps.s-......sIHluoCht...ptt..............CPp..hcphpchlpcch...Gh.plVpGTH...........	0	37	67	74
+8655	PF08822	DUF1804		Protein of unknown function (DUF1804)	Bateman A	anon	PSI2 target CAB84459.1	Family	This family of bacterial protein is uncharacterised.	29.00	29.00	29.60	31.50	28.50	27.30	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.76	0.71	-4.51	12	154	2012-10-04 14:01:12	2006-05-16 15:50:41	6	2	139	0	18	111	2	157.70	37	93.63	CHANGED	M.AHspEsRctlRphYVhsphoLEhAAhpsGVshuTARRWKpcA+spGDDWDKsRAA.tlAuGGlE-luRphLssallQapsTMctLp...pspslssuc+sclLASLuDuasKTluAs...+RlhPETscLAsAl-llphlusalpp+aPpHl.AasElLEPFG.plpKca	.....................MAaspch+cthRchYlhsphsLptuAthhsls.sTARpWKptsctcG...DDWDKhRsAphLAu.ssl-clupulltuFh...hQhpssh-plp.......sspchsspcKschLAuLuDuFoKhhuuu...++lhP-oscLusAhcllc.h.lhualppc+Pcplsshl-lLEshu..ltc.............................	0	4	9	15
+8656	PF08823	PG_binding_2		Putative peptidoglycan binding domain	Bateman A	anon	DUF1028 C-terminus	Domain	This family may be a peptidoglycan binding domain.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.59	0.72	-3.88	9	96	2012-10-01 23:43:47	2006-05-16 17:46:52	6	6	94	0	51	368	46	69.20	26	22.05	CHANGED	hhhcp.cs.tphslscDhtsplpsuLtcLGY...........ppthtcALpsalthpNFEs+.............hpscsp.IspsVhpaL	..........................................pstphhslsschtpplpphLpchGa..ht..t.....s........h.spshppALpsahuhENhEpR.....................htsss..ID.tVLphh..............................	0	23	36	46
+8657	PF08824	Serine_rich		Serine rich protein interaction domain	Mistry J	anon	pdb_1z23	Domain	This is a serine rich domain that is found in the docking protein p130(cas) (Crk-associated substrate).  This domain folds into a four helix bundle which is associated with protein-protein interactions [1].	21.00	21.00	21.00	21.20	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.95	0.71	-4.52	12	250	2009-01-15 18:05:59	2006-05-17 14:37:00	5	8	78	2	110	232	2	155.60	43	19.69	CHANGED	LDL-sAhEpLs+LQpplsSSVutLhsFVu.....ssWRshsp.hEsslpcl+tAs-+lctul+-hL-Fu+GshusAsphsDpsLpsKl+cQLQplc-uaQhLlctppsLDsss.WohphLsts.tsps.....ssDDL-RhlhsARslP-DsKphAShltuNupLLF+Rssp	..............L-L-sAlEpLtRLQ......pslssoVupLhshlu.....ssWRs.hs....hEsplp-l+sAls+Vcsul+-hL-F.A+GAluNAup.....hsD.......psLpsKLp+QLQ+lEDuaQhLhppupsL-sss..WulshLshs...t..s...............ssDDLDRhVhsuRsVP-DsKQLsShl......p............uNApLLF++s..s...........	1	20	31	61
+8658	PF08825	E2_bind		E2 binding domain	Mistry J	anon	pdb_1y8x	Domain	E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades.  This is an E2 binding domain that is found on NEDD8 activating E1 enzyme.  The domain resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains [1].	20.30	20.30	20.40	21.90	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.69	0.72	-4.22	24	285	2009-01-15 18:05:59	2006-05-17 16:11:40	5	11	231	29	198	288	4	85.70	38	19.97	CHANGED	lphssshTLp-lI-pLscpschQl+pPSls.....sss+sLYhtss..spLEctT+sNLs+pLt-L.lpcGpElsV.........oDsshs.hshplplpFp	..........hphssssoLp-ll-hL..sp.ps..ph..QhKsPulo.......ucs+oLYhpss..sslEE..pTRsNLsKsL....p....E.....L.....l.......t-GpE........lsV.........sDsshs..tshph+LpF...............	0	70	109	164
+8659	PF08826	DMPK_coil		DMPK coiled coil domain like	Mistry J	anon	pdb_1wt6	Domain	This domain is found in the myotonic dystrophy protein kinase (DMPK) and adopts a coiled coil structure.  It plays a role in dimerisation [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.93	0.72	-4.07	6	271	2009-01-15 18:05:59	2006-05-17 16:41:07	5	15	56	3	115	239	2	59.70	48	4.79	CHANGED	ELQSALEAEIRAKQulp-ELpKVKsuNlshEsKLp-oEsKNpEL.pElcpL+K-MEE.hRuc	..................ELQSAL-AEIRAKQulQEEL.p.c.V+suNlphEs+L+-uEt+Np-L.pElcpLpcchE-.hRuc........	0	12	19	55
+8660	PF08827	DUF1805		Domain of unknown function (DUF1805)	Mistry J	anon	pdb_1qw2	Domain	This domain is found in bacteria and archaea and has an N terminal tetramerisation region that is composed of beta sheets.	21.40	21.40	21.40	30.20	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.46	0.72	-4.17	18	202	2009-01-15 18:05:59	2006-05-17 17:03:56	6	1	201	1	63	138	3	62.30	62	62.88	CHANGED	hCGhLsVsshp+......hG.sAu+Vp......GVcTl-DhLpuplhsloptAccLGlcsGMoGcEALp+h	.....................MCGALDVuLLNEKL..tDRGIIAGRAV......GVRTIEQLLEAPLESVThtAEsLGIpsGhhG+EALLKM.	0	19	45	50
+8661	PF08828	DSX_dimer		Doublesex dimerisation domain	Mistry J	anon	pdb_1zv1	Domain	Doublesex (DSX) is a transcription factor that regulates somatic sexual differences in Drosophila.\	    The structure of this domain has revealed a novel dimeric arrangement of ubiquitin-associated folds that has not previously been identified in a transcription factor [1].	20.70	20.70	20.90	39.70	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.98	0.72	-4.44	11	105	2009-01-15 18:05:59	2006-05-17 17:27:46	5	3	47	6	15	114	0	59.40	55	18.06	CHANGED	lspDslL-pCQ+LLEKF+YPWEMMPLMYVILKsAcuDl-EASRRI-EGphllppYppppphs	....spDhhL-aCQKLLEKF+YPWEMMPLMYVILKDAsADlEEASRRI-EGptllNph.p.p.............	0	4	8	12
+8662	PF08829	AlphaC_N		Alpha C protein N terminal	Mistry J	anon	pdb_1wym	Domain	The alpha C protein (ACP) is found in Streptococcus and acts as an invasin which plays a role in the internalisation and translocation of the organism across human epithelial surfaces. Group B Streptococcus is the leading cause of diseases including bacterial pneumonia, sepsis and meningitis.\	 The N terminal of ACP is associated with virulence and forms a beta sandwich and a three helix bundle [1-3].	20.20	20.20	20.30	30.40	19.80	18.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.26	0.71	-4.96	5	46	2009-01-15 18:05:59	2006-05-18 09:50:22	5	22	21	2	1	51	0	177.50	50	32.35	CHANGED	VTQGQlNIFs-TVlAAEVIsGSAATLNTulTKNlQNGNAYIDLYDVKNGKIDPLQLIVLsPsuYoApYYI+QGuKYYosVSELQTsGuAoITYNILcEDGsPHsKoDGQIDIVSVuLTIYDSTsLRDKI-EVcsNANDPKWSDGSRDEVLTGLEsIKsDIDNNPKTQoDIDNKIlEVNELEKLLVl..slPDKDKY	...............hTQsphNI.p-olhAApsIsGSA.sTLNTshTKNlQNGpAYIDlYDVK.GhIDP.pLIsLss.uYoApYYI+QGucYao..sssclpoTGuAoITYslLDcsGsPapKuDGQlDIVSlslTlYDoosLRspI-EVhppAsDPKWS-GSRDEVLpuLEcIKpDIDNNPKTQsDIcsKIsEVNplEKhLss...hPDt.K..............	1	0	0	1
+8663	PF08830	DUF1806		Protein of unknown function (DUF1806)	Mistry J	anon	pdb_1njh	Family	This is a bacterial family of uncharacterised proteins.  The structure of one of the proteins in this family has been solved and it adopts a beta barrel-like structure.	19.60	19.60	19.60	25.00	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.62	0.71	-4.28	14	377	2009-09-10 16:05:25	2006-05-18 10:39:37	5	2	372	1	40	133	2	115.10	62	96.23	CHANGED	csIppppVQphL-pFsN+sVYlHLETTNGAYAuHaD-ph.aosGAaIRNAplpYc+uKIs.GsG.PYRVGLKh..stGWlYAEGLTcaElD-psRLLlAGHs.pG+LAlALEIScpPFs	..........................pPIccp-V.chLsoFtpKPVYLHlETTNGAYAsHFDp+s.FsAGsFlRNhplTYp+AplK..Gsp..PYRlGLKL..stGWVYspGLTHaE..Vs-+-chLlAGashEGpLAsALpIScpPFs.	0	13	25	34
+8664	PF08831	MHCassoc_trimer		Class II MHC-associated invariant chain trimerisation domain	Mistry J	anon	pdb_1iie	Domain	The class II associated invariant chain peptide is required for folding and localisation of MHC class II heterodimers.  This domain is involved in trimerisation of the ectoderm and interferes with DM/class II binding.  The trimeric protein forms a cylindrical shape which is thought to be important for interactions between the invariant chain and class II molecules [1].	25.00	25.00	55.00	55.00	21.50	18.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.71	0.72	-4.13	10	94	2009-01-15 18:05:59	2006-05-18 11:36:40	5	6	54	3	27	80	0	70.80	51	27.02	CHANGED	NhTEDQV+HLLhpuDPhKhaPpLKsohhsNLKsLKsoMsssDWKsFESWMHpWLLFEMAKsshs-.cPsphPA	....NhTEDpVhHLLhpuDPhKhaPpLKsoF.-NL++LKpoMpshDWKsFEoWMHpWLLFEMu+pshpp.cPTthP...........	0	1	2	11
+8665	PF08832	SRC-1		Steroid receptor coactivator	Mistry J	anon	pdb_2prg	Domain	This domain is found in steroid/nuclear receptor coactivators and contains two LXXLL motifs that are involved in receptor binding [1].  The family includes SRC-1/NcoA-1, NcoA-2/TIF2, pCIP/ACTR/GRIP-1/AIB1.	25.00	25.00	33.60	33.60	18.90	18.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.00	0.72	-3.23	10	234	2009-01-15 18:05:59	2006-05-18 11:48:35	5	17	49	173	84	190	0	82.50	50	6.17	CHANGED	Kupp....KLLQLLTopo-pht......shtsusssssKDuhus........ussSssuussosso...........SLpEKHKILHRLLQsusSPsDlAKLTAE	......................................Kupp....KLLQLLToso-pht................hs.u.s.lssssKDusus............sussSusu.ussoSsS.............................SLpEKHKILH+LLQsGsSPsDlAKlTAE......	0	3	9	31
+8666	PF08833	Axin_b-cat_bind		Axin beta-catenin binding domain	Mistry J	anon	pdb_1qz7	Domain	This domain is found on the scaffolding protein Axin which is a component of the beta-catenin destruction complex.  It competes with the tumour suppressor adenomatous polyposis coli protein (APC) for binding to beta-catenin [1].	20.00	20.00	20.20	20.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.42	0.72	-4.25	9	177	2009-01-15 18:05:59	2006-05-18 13:19:08	5	6	76	1	81	150	0	40.50	58	5.22	CHANGED	EDsPpuILD-HVSRVh......+TPGspSPss........hp+ps..tupSP-s	....EEsPpoILD-HVpRV.h......+TPGCQSPGs.........upass..tpRSP-..........................	0	16	23	47
+8669	PF08837	DUF1810		Protein of unknown function (DUF1810)	Mistry J	anon	pdb_2d2y	Family	This is a family of uncharacterised proteins.  The structure of one of the members in this family has been solved and it adopts a mainly alpha helical structure.	25.00	25.00	25.90	25.90	23.10	16.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.82	0.71	-4.60	44	312	2009-01-15 18:05:59	2006-05-19 14:32:37	6	6	292	1	118	297	33	135.90	48	84.13	CHANGED	sDs..acLpRFVpAQss..lYspslsEL+sG+KpSHWMWFlFPQlpGLGpSshAp+YuIsShsEApAYLsHPlLGsRLhEsochllshpucosppIFGsPDshKh+SSMTLFutsss....ssssFppsL-paasGp.DstTlphLs	.........................sa-LpRFVpAQps.........lYppslsEL+uG+KpoHWMWFlFPQLcG..LGpSshAp..pYuIuul-EApAYLtHPlLGsRLcEssphlht.l.p.s.+.o..sppIF..G.s.PDshKhpSSMTLFutsss............ss..ssFttsLs+aasGp.DttTlphL.s..........................	0	45	76	98
+8670	PF08838	DUF1811		Protein of unknown function (DUF1811)	Mistry J	anon	pdb_1sf9	Family	This is a bacterial family of uncharacterised proteins.  Some of the proteins are annotated as being transcriptional regulators (see Swiss:Q4MQL7, Swiss:Q65MA2).  The structure of one of the proteins in this family has revealed a beta-barrel like structure with helix-turn-helix like motif.	20.60	20.60	21.00	60.70	20.30	18.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.33	0.72	-4.06	15	365	2009-01-15 18:05:59	2006-05-19 16:33:10	5	1	364	2	38	123	0	100.90	62	97.01	CHANGED	-KRYS-MocaELcpEIAtLpEKARKAEQhGhlNEaAVhERKlhMAcAYLlDPs-FcsGchYclc.sssphF+lcYLNGVFAWGaRhs....usppEEALPISLLpc	....K+hSEMSE.ELRcEIplhKEKh.R.KAE.pGIlNEYDVYppKllhAcSYLl.DhpKlcIGcIY+Ls-GospYFKV-hLKGlFAWGaRhs......SDcsEEGLPIuLLQ.h.	1	11	23	32
+8671	PF08839	CDT1		DNA replication factor CDT1 like	Mistry J	anon	pdb_1wlq	Domain	CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin.  Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin.  This region of CDT1 binds to Geminin [1].	21.70	21.70	21.90	21.80	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.01	0.71	-4.30	11	217	2009-09-10 23:23:53	2006-05-19 17:18:32	6	4	153	3	161	226	0	153.10	25	25.92	CHANGED	LPhKYchLtEhFcslDolsshhcpRscphTFsp.lptsVQchs+KpFs.sHLuQIKplaPpuhplc........p.phhsaspsopp.hYpLpIc..lst.............................................tsssppphsssphhpRtplF+phLl-hsKppcptaL.p..s.s....pp.l...thps.Fpl-p.s.-ls.ucLPp	.......................LP.caphLt-hFcsh-......olls...hLp.sR...pc.s.s.TFsp.lppsVpphh.+......+.pFp..pcluQIKtlhPp.uhphc.......................tt.h..thppts...p.p....hp..l...hlp..htt......................................................................s.t..p..hs..tp.h.hht....ctphFpptLlphlpppcpt................................................................................................................................................................................................................................................	0	55	89	133
+8672	PF08840	BAAT_C		BAAT / Acyl-CoA thioester hydrolase C terminal	Mistry J	anon	Pfam-B_4571 (release 20.0)	Domain	This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.15	0.70	-4.63	24	605	2012-10-03 11:45:05	2006-05-24 14:29:18	6	14	292	4	300	3028	585	192.20	24	50.28	CHANGED	lcLEYFE-AlsaLhpHPpVptstlGllGlShGu-lsLuMuuah+..plsAsVsINGosssshsshha+t..............slsslshshpclph..........stsshhphhchhpshhspssppshIPlE+u..csshLhlsGpDDpsWtSthaAc.hpc+LpppG+c.pspllsYPsuGHhIEPPYhPhstAshthhhs......hhaGGEs+sHAhAQ.DuWpcl.tFF+KHLsu	.......................................................................................................................................LEaF-c.....Ah.pal..h.p.p.s....p..............l.p.....s.s..t.lGlhGhS+Gu-.ls.L.h.hA.u.......h...ht.........pl.s.....s...s....V........s....l....s.....s...u.s...s...s..h.t..s....h...h.h.ct.t................................................ls...l....h..p..h..p.p..h..ph......................................p.s.sh...h..t..h.h..........h...h.....t..................t.....t.........t...p.......p...s..h.....I.........s......l...E....ch..........pus.hLh.....l.s...............G.p..DD.p...W.s..S...t.....h..u...p.h.....pp.Lp.t.p.....s.p.p....p...hph.l..pY.......................suG..H..h...l....p..s.P.....a.h.P.h.p....h.sh...................hhhGG.pstspuh..Ap.cuWtph.tFhppth..s..................................................................................................................................................	0	52	103	210
+8673	PF08841	DDR		Diol dehydratase reactivase ATPase-like domain	Mistry J	anon	pdb_2d0o	Family	Diol dehydratase (DDH, EC:4.2.1.28) and its isofunctional homologue glycerol dehydratase (GDH, EC.4.2.1.30) are enzymes which catalyse the conversion of glycerol 1,2-propanediol, and 1,2-ethanediol to aldehydes [1].  These reactions require coenzyme B12.  Cleavage of the Co-C bond of coenzyme B12 by substrates or coenzyme analogues results in inactivation during which coenzyme B12 remains tightly bound to the apoenzyme.  This family comprises of the large subunit of the diol dehydratase and glycerol dehydratase reactivating factors whose function is to reactivate the holoenzyme by exchange of a damaged cofactor for intact coenzyme.	24.60	24.60	24.60	24.70	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.90	0.70	-5.61	12	375	2012-10-02 23:34:14	2006-05-24 16:49:07	5	1	324	6	39	285	7	314.90	70	55.80	CHANGED	pV-lspGA-tIMpslstssslpclpGEsGTNlGGMLE.+VRQsMAsLTspsss-IhIQDLLAVDThlP.pVpGGlAtEFShEpAVG.IAAMVKuD+LQMphIApplcpclshsVclGGsEAEhAIhGALTTPGTspPLAILDlGAGSTDASIIspcsplsAhHLAGAG-MVTMlIsoELGLpshtLAE-IK+YPLAKVESLFplRHEDGsVpFF-pPLssslFARVVllKp.sshlPl.suphSlEKI+.lRpsAKc+VFVTNslRAL+pVS..PTGsIRDIsFVVLVGGSALDFElPQhVT-uLu+aslVAGRGNIRGhEGPRNAVATGLlLsaspc	........................................................................cVDVAtGAEAIMcAVsuss+L-NloGEsGTNIGGMLE.+VRQTMA-LTsKs......ss-IaIQDLLAVDT.VPVsV.............pGGLAGEFShEQAVG.IASMVKSDRLQMAhIAp......EIc..p+LslcVplGGAEAE.......AAIlGALTTPGT.s+PLAILDLGAGSTDASIINscGEIl..AT.H.L.AGA..G....DM....VTMII......spELG.L-.DRYL.....AE-IK.KYPL.AKVESLFHlRHEDGoVQFFssPLsPsVFARVs.l.VK.P.DcLVPl..PGDlsLEKlRslRRSAKERVFVTNALRAL+pVS..PTGNIRDIPF..VVLVGGSSLDFElPQLVTDALuHYpLVAGRGNIRGoEGPRNAVATGLlLuapp................................................................	0	14	21	30
+8674	PF08842	Mfa2	DUF1812; Mfa;	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2	Bateman A	anon	PSI2 target AAO79331.1	Family	This family of proteins may be lipoproteins principally from bacilli.  They are between 300 and 400 residues. Many Bacteroides-like bacterial species, including Porphyromonas gingivalis, the causal agent of periodontal infection, carry at least two types of fimbriae, namely FimA and Mfa1 fimbriae, following the names of their major subunit proteins [1]. Normally, FimA fimbriae are long filaments that are easily detached from cells, whereas Mfa1 fimbriae are short filaments that are tightly bound to cells; however, in the absence of Mfa2 protein, the Mfa1 fimbriae are also very long and are not attached. Mfa2 and Mfa1 are associated with each other in whole P. gingivalis cells to the extent that Mfa2 is located on the cell surface and probably associated with Mfa1 fimbriae in such a way that it anchors the Mfa1 fimbriae to the cell surface and regulates Mfa1 filament length [2].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.11	0.70	-5.05	87	437	2012-10-02 11:46:57	2006-06-01 18:05:17	5	5	93	5	62	421	4	277.90	14	80.67	CHANGED	hs.sCs...............shtlphp........ashs...............ttssshspplpplslalFD.....t.sGp.hhpphshpspplt.....tt...............................hh.tlssG.p...Ypllsau........sh.......pppt..................hsssssl...sclphplpp............tssthst......phssLa....aGph..shsh...........tstpppphslsLh+sssplpl..........hlps...........t..s.shsshp......hplpssssph...sassph.....hsspshsahPh...........tt.ssssss..................hhsph.sshphhpsp....thpl....pltppssstph......phs.h..h...............hsspthlsppsph...sl.hhh......................st.......................hssplpls.sWthhtps	............................................................h.l.h...........h..t...............t.spthtpplpplplalFD.........p..sGp..hltphphp..sppht.............tt.................h.h.............hhplssG.s...Yp.hlsau..............sh........sspt..hs..........................hsssssl..............pchhhphpp..............tsshhst.........phssLa.............aGph..shsh.....................tssttpphslsLh+sssplpl................hlps....................shss.hp................h.pltss.ssth.........shssph......sspshtahsh.....................htt.psptst............................hhsph..pshphhtsp.........................thpl.......plhtpssstth.....hp.s.h..h..........................s.p...lst.ppph....l..hhh...................................t......................hthtl.ls.sW.hh.......................................................................................................................................................................................	0	13	47	62
+8675	PF08843	DUF1814		Nucleotidyl transferase of unknown function (DUF1814)	Bateman A	anon	PSI2 target CAD86002.1	Domain	This large family of proteins are largely uncharacterised.  Some are annotated as abortive infective proteins but support for this annotation could not be found. This family was recently identified as belonging to the nucleotidyltransferase superfamily [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.54	0.70	-4.58	177	2210	2012-10-02 22:47:23	2006-06-02 11:52:52	6	12	1271	0	615	1962	254	226.00	14	83.81	CHANGED	thLtplh.....sthtpphs.hKGGTuLshh.h......hh....RhScDlDhhhht...................ttphpph.....hptlppth............................................sshthphpthhtts......................................st.ptplcl-lsht.........h..st.h..hsh.............................shshpclhucKltAhhp..................................th.RDhaDlhhl.........................htttththtphhps.h...........ht.....phppp....tpthhtphth................................................phhpp.htt..tt...........................................phpthhpp	.................................................................................................................................h.....h........htpphh.hpGGoulshh.t......h.t.......R.hotDlDhhhh......................................php.ph............hptlp..phh................................................................pt..hhhphpthhtt..........................................................t..tttlpl-lsht.........................sht.h...hthh...t.........................tl......shsh..tph.hupKltuhhp......................................tph.+DhaDlhhl...............................tttths.tthhpt.h.......................................ht.t...............................................................................................................t............................................................................................................................	0	204	415	530
+8676	PF08844	DUF1815		Domain of unknown function (DUF1815)	Bateman A	anon	PSI2 target ZP_00111304.2 (BIG_33)	Domain	This presumed domain is about 100 amino acids in length and is functionally uncharacterised.	25.00	25.00	26.00	76.70	23.10	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.41	0.72	-4.42	11	59	2009-01-15 18:05:59	2006-06-02 11:56:19	5	1	57	0	24	60	27	102.00	69	88.83	CHANGED	FhRLA-QYRshVQDLVMSLQALApuLcppGhsASCYoC....Gc-hcuASFhssLG-sHhlRFLVSDaGISWsE.RssRELVKLEGAEAIpcLQclAshl+pspsssu	FhRLApQHRpFVpDLVMsLQALAhlLEpRGYhASCYTC......GsphNSASFMVSLG-sHLIRFLVSDYGITWTEMRDDRELMKLEGAEAIsQLQELAsLlKhp....ss....	0	3	15	22
+8677	PF08845	SymE_toxin	DUF1813;	Toxin SymE, type I toxin-antitoxin system	Bateman A, Eberhardt R	anon	PSI2 target AAC77303.1	Domain	SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin [1,2].	20.70	20.70	21.00	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.80	0.72	-4.12	23	839	2012-10-01 20:57:08	2006-06-02 12:01:30	5	3	449	0	149	526	5	49.20	39	50.52	CHANGED	tRhhTV.....................GYs.http.t..........sPslpL+GcWLEpuGFssGp.lplpVppGpLVIps	....................................l..uYh....p..............h.....PslpLpGpWL.cpAGFsoGpsVsV+VhcGClVlp...........	0	19	51	90
+8678	PF08846	DUF1816		Domain of unknown function (DUF1816)	Bateman A	anon	PSI2 target ZP_00109395.2 BIG_34	Domain	Swiss:Q4C9H3 is associated with the Pfam:PF01383 domain suggesting this presumed domain could have a role in phycobilisomes.	20.50	20.50	21.00	35.40	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.17	0.72	-4.28	29	104	2009-01-15 18:05:59	2006-06-02 12:48:16	5	3	70	0	46	121	101	67.20	41	56.63	CHANGED	uhuNth.GLAWWs+lpTpsPssTYaFGPFlocpshctplssalpDLpsEuspsIppsllRs+........+sEsLTl	...........p.hGhAWWlcIpTppPcCTYYFGPFhopp-AptthsGYlEDLpsEGApsIphslpRCp.PcsLTl..............	0	7	32	44
+8679	PF08847	DUF1817		Domain of unknown function (DUF1817)	Bateman A	anon	PSI2 target ZP_00111140.1 BIG_36	Domain	Members of this family are functionally uncharacterised.	25.00	25.00	25.80	25.10	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.70	0.71	-4.65	21	131	2009-09-10 22:53:16	2006-06-02 12:51:59	6	2	119	0	42	100	33	134.30	40	60.20	CHANGED	plss-uIppLDLoPlpthhp.........pshsslLststsLphphsaPRs.ssDPR.ELSEhPEsRLWhlRhDApYPWLPLLL-hpsGpLsRasAMLVPHpFstsEGlpFsPEALElalhH+lFlLscahppp.Gls..ppu.pLppMAthLGY-LDsuFasLl	.......................................s.lsp-plppLDLSPlpphhc........hhptps.lhh.ppslthslpa.ps.ssDPR.ELuElPElRLWF.lRLDusYPWhPllLDhpt...GplhRasAMlVPH...........ph...p.t.G...l.a.sPpALElalhp+lh...hl.phhpp..ths..t...phtphAthhGatlssthap................	0	8	29	38
+8680	PF08848	DUF1818		Domain of unknown function (DUF1818)	Bateman A	anon	PSI2 target ZP_00110314.1 BIG_37	Domain	This presumed domain is found in a small family of cyanobacterial protein. These proteins are functionally uncharacterised.	25.00	25.00	53.90	32.60	19.30	19.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.51	0.71	-4.03	27	71	2009-01-15 18:05:59	2006-06-02 12:59:54	6	1	70	5	30	76	118	115.20	41	87.84	CHANGED	.pEGsGWRLuhDPs+spassLIGGEsWAlELTcsEhpshspLlhpLscphpsltspLMsEEpIsLElEpt.hWhpl-GptpsWuL+lILpss.......RusEGtWPAssssslstAhcplh	.l.+cGsGWRLGaDP...p.t...spassLlGu-sWAlELTcsEhs-hscLltpLspshptls..s-.L..M-EEpIshEhEsphlWhplEGhspsaoL+hILpss.......RpsEGtWPssssssLltAhppl............	0	6	20	28
+8681	PF08849	DUF1819		Putative inner membrane protein (DUF1819)	Bateman A	anon	PSI2 target ZP_00108899.1 BIG_41	Family	These proteins are functionally uncharacterised.  Several are annotated as putative inner membrane proteins.	20.30	20.30	20.60	22.60	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.78	0.71	-4.89	25	271	2009-01-15 18:05:59	2006-06-02 13:12:16	6	1	259	2	54	226	31	176.70	23	85.97	CHANGED	sppcYpsslsuGuLhlpES+plAcLhLpshsh-phccplhp-NlLQppo.uos+Rhs+pl.tpRLcoLssc.h.....phls-.usppptpplLahAsh+psplltDFhh-Vlp-+ahphchcLstcsastFhspps-hcsplsphSsSTptKLpQlla+hLtEAGhLtt..scspplpsshluscltphLpc.psppclh	............a.uslhutshhhpE.+hlspLhhps....s.pphp...ptlhpcNlhptsotsosc+hspsl.ptR.LpsLsps.hh....................phlsp.....us.pppp.lhh...huhhhps.llt-FhtcVlpcthhph...c....plstpchptFhppp.tp.ppstls.s.ao-sThp+htsshhphLt-uGh..lps....scp..c.plp....hhl..ph.thl.t.......h.......................	2	21	37	48
+8682	PF08850	DUF1820		Domain of unknown function (DUF1820)	Bateman A	anon	PSI2 target AAG07366.1 BIG_46	Domain	This family includes small functionally uncharacterised proteins around 100 amino acids in length.	20.90	20.90	25.90	25.70	20.80	18.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.22	0.72	-3.90	21	216	2009-01-15 18:05:59	2006-06-02 13:18:53	6	1	215	0	60	152	247	98.60	49	90.46	CHANGED	pslY+lhFhNpsplYElYARplhQSchaGFlElE-FlFuE+opllVDPuEEKLKsEFuGVpRoa...IPMHullRIDEVcKcGsuKIo-spst...ssVssF.Phs	..t.slY+lhFl..N.pGc.lYE.lYARplhpSs.L.aGFlEIt-FVFsp+osllVDPSEEKLKsEFsGVpRSa...lPhHuIlRIDEVc..+..c..Gsu+Io-ht.....sNVhsF.Ph..................	0	14	33	45
+8684	PF08852	DUF1822		Protein of unknown function (DUF1822)	Bateman A	anon	PSI2 target ZP_00109005.1 BIG_39	Domain	This family of proteins are functionally uncharacterised.	25.00	25.00	29.20	28.60	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-12.21	0.70	-5.64	27	120	2012-10-11 20:01:01	2006-06-02 13:41:17	6	3	38	0	42	154	0	290.10	19	92.18	CHANGED	l.lsssspptA.phupphssspcphpsYL.NpLAltultsWLpt...-hpsshpsssthps.lsphh-.Vsshtls.th.t+l.hlsspshps...s.lplPpEh..hsshlu..YlsVpls.-tp.sclhGalstppl.........pst.cpshplshp.......cLhs.hshLp..hstp.tss..t.....s.h.......h...lpp.Lts..hs......sap..htsLlt.st....h...p........................................................................................h.t..............hths.....tthppsttlshthplsspsh...tLhltht.pssp.phtlhhpLpsht......ssshLPsulpLpllscstpsh.pspsps....p..c.hlplp.hpsp.Gppaplclthss...hhpE.hh	..........................................................................................................l..t..p.u...p...ut..t....s.tpt.psal.NtLulhsh.taLp.........th..php..s.hps..h.phht..lssh.l.....th.h+....lthhshtt.pp...t.hpl.P.Eh..hs......phhu..YlsVpls....p.p.splhGahpt.................tt.pl.shp.....................pL....thl..........................................t.......ltp.ltt..............sap....httl...ht.......h..................................................................................................................................................t........t...hptsthlshthp.hstp..l...hLhltl....sp.spp..phtlhlplhsht.............tpthLP.slpLtllspssphh.pstspt......tsphlplp.hpsp.uppFplplthss....hpE.h...........................................................................................	0	4	33	42
+8685	PF08853	DUF1823		Domain of unknown function (DUF1823)	Bateman A	anon	PSI2 target ZP_00108651.1 BIG_42	Domain	This presumed domain is functionally uncharacterised.	25.00	25.00	79.40	78.40	24.50	17.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.47	0.71	-4.35	21	75	2009-01-15 18:05:59	2006-06-02 15:29:12	6	1	75	1	32	79	121	115.90	52	79.95	CHANGED	PLocslLhtILpD+lSDthVspLlWp+LGYphcs..ss...WssussoPp.Wp-caPcsPphIupRPAoV+LTRSIPKEaKQLLKcpLGFpGY+IuELhPRRTRRATAVNWLLualtpp	..PLsp-slhtILs-clsDphVspLVWphLGYRh-tsp.sp........WssupVssp.Wp-cYPcPPshIs.s............R............P...AoV.....+LTRSIPcEpKQLLKEp...L...GFcGY+IGEhsPRcTRRATAsNWLLuahtp.p...	0	8	22	31
+8686	PF08854	DUF1824		Domain of unknown function (DUF1824)	Bateman A	anon	PSI2 target BIG_44	Domain	This uncharacterised family of proteins are principally found in cyanobacteria.	25.00	25.00	36.00	42.20	17.80	18.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.51	0.71	-4.50	23	72	2009-01-15 18:05:59	2006-06-02 15:34:20	5	1	72	3	32	77	106	124.00	34	83.93	CHANGED	lspLpDLspLRsA....PpLssspccpLtpELpthhssu-WhTlGlMAPSsppAlpALRshppthuast....hpsh-.....pspt-G.sVFLKuNQpoGslalRsEpGLGcGlLlosptsccspsusTaGPLPLDhF	....................phLp-hssLcht....s.ls.sppccpL+ptLhhhhstu-....a..........slGIhAsosppAltAL+shppuhuatt......hps.....s.......tss.-G.sVaLKhNppoGshalcs.sGht+GVLlSCQusp....ss..t.ssTaG.hPLDhF...	0	7	21	30
+8687	PF08855	DUF1825		Domain of unknown function (DUF1825)	Bateman A	anon	PSI2 target BIG_45	Domain	This uncharacterised family of proteins are principally found in cyanobacteria.	25.00	25.00	29.10	38.50	24.60	21.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.47	0.72	-4.05	12	99	2009-01-15 18:05:59	2006-06-02 15:37:52	5	1	99	0	33	86	318	104.30	55	89.98	CHANGED	Mu.FF-SEIVQpEA+plFp-YQpLhplGupYGpFDREGKhhaI-pMEpLh-R.+lFhKRhELS..DDF.ApMshcQlcsQLstFGhoP.p...pMF-QMspTLE+MKsphc	........Mu.FF-SEIVQpEAKpLFpDYQpLhpLGuc..YGKFDREGKKhFI-pMEsLM-RY+lFMKRFELS..EDF.AphTlEQL+TQLuQFGhTP.p....QMF-QMstTLERMKspl.........	0	8	23	31
+8688	PF08856	DUF1826		Protein of unknown function (DUF1826)	Bateman A	anon	PSI2 target BIG_48	Domain	These proteins are functionally uncharacterised.	20.70	20.70	21.10	21.20	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.41	0.71	-4.55	50	214	2009-01-15 18:05:59	2006-06-02 15:45:18	6	1	195	0	63	230	227	184.90	32	84.78	CHANGED	shussPslLssIhps.ssNlAlWpRpLssplppalstllsp.p.sshphthsltsspsshcshppths....sspttpsLhpDluhLlchFssLhshcplGLRLclLcpsMCPRFHVDpVPsRLlsTYpGsGTpWLtptsssRstLG...t...sp.........tpIpplssG-VALLKG-tW.G.NEssGLlHRSPsh..s....sGcpRLLLoLD	.................................................................................................h.stpstsLsplhps.slNlulWpRplsstltphhs.th...ht.t....sh.th.hsh.........tt....t...ht....h.tths...................sh.shpshltDlshLspha....s....sLh..shc..plGLRLcsls...psMCPRFHVD+VPs...R.....Lls..TYtGsGopWLtpsshsR....p..L....u..th.ttt..spt.................................spIpplssG-VALLK.Gc.p..W.......G......N...........cst............GL.....lHRSPsh...s........ss.ptRLlLoLD......................	0	19	37	54
+8689	PF08857	ParBc_2		Putative ParB-like nuclease	Bateman A	anon	PSI2 target AAG07772.1 BIG_47	Domain	This domain is probably distantly related to Pfam:PF02195. Suggesting these uncharacterised proteins have a nuclease function.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.22	0.71	-4.41	15	262	2012-10-01 20:12:50	2006-06-02 16:09:00	6	2	211	6	96	234	41	170.00	34	65.27	CHANGED	pllplslssLRPTQhsVGhtEVptKppcap....................cppc.ppppc....aLcsHhl.........................................PVVlGPsu.phallDHHHlsRALh-hGspp.................VhspVluDLSsl.spssFWphMcsptWVaPaDs+Gp.++shspLPcslt........sLcDDPYRSLAuhL+ptGuacKss..sPasEFtWAcaLRc+	.............p.hh.lplspL+PTQhslGhcpVttKtt+ap....................thst..+phps.......ah..ts+hl................................................PlVlGP.........sG.phYlsD+HHhhpALh-t.s..ssp................................Vhs...h.V..hs-Luth...ststFWptMppppWla...hD...scGt.phs....hspLPssLs..........................sLpDDPYRSLuhhlRctGhhtcss................ssF.EFhWADaLRp.........................	0	21	40	70
+8690	PF08858	IDEAL		IDEAL domain	Bateman A	anon	Bateman A	Domain	This short domain is found at the C-terminus of proteins in the UPF0302 family.  The domain is named after the sequence of the most conserved region in some members.\	 The function of this domain is unknown.	20.40	20.40	20.80	20.80	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.54	0.72	-4.46	42	993	2009-01-15 18:05:59	2006-06-02 16:24:31	5	2	543	3	101	402	1	36.70	34	26.17	CHANGED	hLccslt.....phpcccLhppIDpALDp+DcctFhpLoppL	....................lpcthp.....phphcpLhppIDpALpppDcptFhpLopch......	1	34	67	85
+8691	PF08859	DGC		DGC domain	Bateman A	anon	PSI2 target BIG_49	Domain	This domain appears to be a zinc binding domain from the conservation of four potential chelating cysteines. The domain is named after a conserved central motif. The function of this domain is unknown.	21.50	21.50	23.30	23.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.39	0.72	-4.20	39	205	2009-09-11 06:56:43	2006-06-02 16:29:11	6	3	167	0	104	181	5	108.80	32	79.43	CHANGED	shlasCSGsSs.sGQluNpsAlcLscpG.h...uchhCluuluupssslhchAcuuctIluIDGCslpCup+sLppsulsscpalhlo.-h.........GlcKpht.tshspp-lpphh.ptltc....h	.......s.llauCSGsSs.luQlANplAlcLs+ts.h....ucMuCluGlGu.slssll+hA.+uucsllAlDGCslsCs+psLpptGlsss..tHlhLs.-h.........Gl.cKpht.....p-hs...t-hpplh.t.h...t................................	0	48	80	91
+8692	PF08860	DUF1827		Domain of unknown function (DUF1827)	Bateman A	anon	PSI2 target BIG_53	Domain	This presumed domain has no known function.	23.40	23.40	23.50	30.20	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.89	0.72	-3.88	15	568	2009-01-15 18:05:59	2006-06-02 16:42:00	5	1	513	4	43	173	0	95.60	51	94.90	CHANGED	M+LINsTNSascLVpsQLssT........DAphVcVYShGNTcVlaTcAPcHhElLIoN++RsI+-sEI-hIhEhhLK+......hspsslcsl+ss+LIEIolP	............MKLINsTN.SHspL......VcsQL-sT........DApLVEVYSAGNTcVlFTpAPhHhEILIoNK+RuIR-sEIEpIp-aFLKRhh.ptshcpssIKsla..op+LItISlP.................................	0	5	18	27
+8693	PF08861	DUF1828		Domain of unknown function DUF1828	Bateman A	anon	PSI2 target BIG_51	Domain	This presumed domain is functionally uncharacterised.	21.50	21.50	21.80	21.90	21.10	21.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.76	0.72	-4.34	22	497	2009-01-15 18:05:59	2006-06-02 16:47:38	5	2	378	0	50	221	4	89.20	31	38.70	CHANGED	TPFh..spGDtltlalcpts..sthhloD-GhTLhcLp.tGhphp..stpRt.cllpslLstaGlphps..upl.hshsstcshutshtshlQulltl	..........TPFhD.phsDpltlahptps...sp......h.pLoD-GhTlhsLE.t.Glsls..pKpRp.clhpslLps..aG...lchs-..pEI...hh...ps...s.p.cshspshasllQslltl............	0	13	27	39
+8694	PF08862	DUF1829		Domain of unknown function DUF1829	Bateman A	anon	PSI2 target BIG_51	Domain	This short domain is usually associated with Pfam:PF08861.	22.20	22.20	22.90	22.90	21.50	22.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.86	0.72	-3.70	14	377	2009-01-15 18:05:59	2006-06-02 16:50:04	5	2	271	\N	25	144	2	86.70	33	36.27	CHANGED	GpSuhpHpFDallspppppsp+hlpshsssspsthpshhasa.Ds....ppscpssschhl..Ih.NDppcplssphpphhppYslpslsaSc+	.......GcSGlhHsFDallssp+.pp.EKhlpshsNhspsplpsthhsa.Dsp....t+ppcp..cppsphhl..Il..N.......Dsp.....cs.....Is...E..cspshhcc.slpllsaSp+.............	0	8	17	23
+8695	PF08863	YolD		YolD-like protein	Bateman A	anon	PSI2 target BIG_52	Domain	Members of this family are functionally uncharacterised. However it has been predicted that thes proteins are functionally equivalent to the UmuD subunit of polymerase V from gram-negative bacteria [1].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.82	0.72	-4.13	39	1100	2009-01-15 18:05:59	2006-06-02 17:07:01	5	1	636	0	106	648	6	85.80	23	75.75	CHANGED	lPEphptlcchhp-.ppKlp.+PhLsppph-clpphlhpuhtpppplploYac.........sGhhhshhsplpplc.hppplphss..t..tpphplphpsIl..cl	...........................hsEphttlpp...-..ppKlp..+sh.Loc.p...phpclp.......h...Lp...p...u...h...t...p...p..p...t...lpl..paac............sGh.h..s.hp.hplhclst..hp.hhlpsps........pphplphtDIlsI....................................................	2	34	66	85
+8696	PF08864	UPF0302		UPF0302 domain	Bateman A	anon	PSI2 target BIG_50	Domain	This family is known as UPF0302. It is currently uncharacterised.	20.40	20.40	21.30	35.80	19.70	19.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.90	0.72	-4.23	21	533	2009-01-15 18:05:59	2006-06-02 17:09:35	5	2	509	3	50	197	0	105.20	42	56.87	CHANGED	cK+pFlcahLppaphKcREuhWlLNYlhsccplLppVHFV-stphss+uLhlostsscs.sFtFa+ssphhscspcsFt-lphN.s-slYlpLpFps...phpsppYls	..KcsFlcahLtpYphKpR.sVWlLNYlh...sp-shLppVHFV-..s.thtspcsLpluss.s...scsss.hpFhKpNl..phhsspchFhDhhh.N...+..s....p.s.laIQlpFts...shpptphL..............	0	18	32	42
+8697	PF08865	DUF1830		Domain of unknown function (DUF1830)	Bateman A	anon	PSI2 target BIG_56	Domain	This family of short proteins is functionally uncharacterised.	25.00	25.00	25.20	36.90	20.00	18.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.38	0.72	-4.35	26	103	2009-01-15 18:05:59	2006-06-02 17:21:47	6	1	68	0	40	121	114	67.00	43	63.27	CHANGED	CsYtNsTs+h.llRshs.ssaYhERVlFPsphhhFEAP.cApLEIassshuushLpsphssscltlsp	.CsYhNsTsplQlsRI.sNlsNaYaERVVFPGp+LlFEAsscApLEIaos.huusILs-pIsCpcLtlp.t..........	0	5	30	38
+8698	PF08866	DUF1831		Putative amino acid metabolism	Bateman A	anon	PSI2 target BIG_55	Domain	Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.	25.00	25.00	37.80	43.40	22.20	19.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.30	0.71	-3.81	22	596	2009-01-15 18:05:59	2006-06-02 17:24:05	5	3	592	1	56	208	0	111.20	54	97.07	CHANGED	MAFpp.olplpGsphpYplssslK+aTL+DssFhpo+sGNapLpR.L-ssss.spuhhLKIoIscDLsuFKhslTstsGL+hVNIFKscppp.h.-paaFlhcsLl-Rplhpc	.....MAFppplpLpssphsYoLSPslKKaTL+DNsFhETKsGNYpLpRhLEpsPsS.s-GFpLKIhINK-LoGhKlsITDpsGLRhVNIFKsEcp+hpQEKFYFLMDuLVERslFsK...	0	11	26	41
+8699	PF08867	FRG		FRG domain	Bateman A	anon	PSI2 target BIG_54	Domain	This presumed domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised.	25.00	25.00	26.00	25.00	21.70	23.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.49	0.72	-3.51	73	450	2009-01-15 18:05:59	2006-06-02 17:25:37	6	4	401	0	125	417	24	102.00	26	31.55	CHANGED	tpsthlFRGp.....ust.sa..t.....LhPolhRtttph.t......................Epph..........lc..............pFccp.................................utt..hhsppss............................hchLAluQHaGlPTRLLDWTpsPLVAhaFAsps.tpts............usla	.................................................................................t....hhaRGp.......sst..pa....t....................LhPolhRtttt.................................Epphhp..............................phhpt..........................................................................................t.t..thp.p.t.....................................hchluhhQHaGl.sTRLLDhTpsPhlALaFAspsttptt.........h.................	0	33	71	99
+8700	PF08868	YugN		YugN-like family	Bateman A	anon	PSI2 target BIG_5	Domain	This family of proteins related to B. subtilis YugN are functionally uncharacterised.	25.00	25.00	27.50	26.80	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.69	0.71	-4.53	26	285	2009-01-15 18:05:59	2006-06-02 17:42:44	5	1	164	3	55	187	0	121.80	41	95.57	CHANGED	h..sSslEGpphpLpcL-plhcshGashuGpWDY-+shaDhKlspc.-G..hhaLRlPshAl-G-lsscsAllcLhoPhLh+HhY.+Gl-.t........................cDtchPpp..hlphucpllp-lccpLp	......hsopl-GtshsLshLc-lMcshGalluGp...WDYE+soaDYKh-....cs...hhaLRV.shAl....-G-l....su....p....pAhl+LhsPhLh+HhYs+Gl-hs...............................s.Dtphspp..hlphucpLlpplEccL..............................	0	17	38	43
+8701	PF08869	XisI		XisI protein	Bateman A	anon	PSI2 target BIG_57	Domain	The fdxN element, along with two other DNA elements, is excised from the chromosome during heterocyst differentiation in cyanobacteria. The xisH as well as the xisF and xisI genes are required [1].	25.00	25.00	26.40	26.30	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.22	0.72	-3.95	34	213	2009-01-15 18:05:59	2006-06-02 17:46:45	6	4	37	7	71	266	3	103.50	39	97.22	CHANGED	MDpLs.pYRplIpplLpcYuph..psspsclEs............pLlhDpp+........ccYhlhslGWcspcRlausllHl-I+ssKIWIppDsTEcGIAp-LlctGlPKpDIVLGF+sPphRpaT-FAVu	................M-.p.l.p..pY+pllpplLpcYuph......tssp.spl-s....................phlhDppp........c+Y.lhplGWpsp.c.R.l.a.usllHl-I.+.ssKIWIppDsTE.uIAp-LlctGlPKpDIVLu.FpsP.hRpaT.saAl.............	0	17	52	71
+8702	PF08870	DUF1832		Domain of unknown function (DUF1832)	Bateman A	anon	PSI2 target BIG_58	Domain	This family of proteins are functionally uncharacterised.	25.00	25.00	25.20	25.70	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.31	0.71	-4.37	23	127	2009-09-10 14:48:39	2006-06-02 17:49:01	6	3	123	0	36	131	30	112.60	30	66.51	CHANGED	+l+lSppuccpLp+LKppTGlss.NllCRhAhstSLppsshsp.....stsh.sDuslEh..shcsas.....G-hsslhhslLKp+h.....s.ph.-scplhcthphHlcRGluhLtschplts....h..pll	..pl+lSppsc-pLp+L.Kp...h..T.sl.ss...NllsRhAhshSLtpsp..h.s.....s.sh....-u.slEh..shpsas...........G-hsslh..h...hlL+t+h.....shth..-pcslhpta+hHlcRGIuhLtschpltp.....................	0	5	25	34
+8704	PF08872	KGK		KGK domain	Bateman A	anon	PSI2 target BIG_60	Domain	This presumed domain is found in one or two copies in cyanobacterial proteins. It is named after a short sequence motif.	21.40	21.40	22.10	22.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.50	0.71	-3.93	9	64	2009-01-15 18:05:59	2006-06-02 18:16:26	5	2	30	0	19	58	0	107.00	25	80.45	CHANGED	s-phcptN..............scDDVl..tscp.......psaKlpclhptlcpthpschhp-h...hp..t.................sphahspGlsCElLchsspsWpKGKl+l.huLEFlPD..E.........Pphs-.ESPLDDIRppIs	..............................................................tcpsl....tp.......phhpltphhphh.t.hpp.....p..t.....h....ht............................................tpha..h...spGlcCclLphGspsWpKGKl+l...............h...........s............LEF..hPD..E..............................sp....pp.p.SPLD-lRp.h........................	1	3	13	19
+8705	PF08873	DUF1834		Domain of unknown function (DUF1834)	Bateman A	anon	PSI2 target BIG_62	Domain	This family of proteins are functionally uncharacterised. One member is the Gp37 protein from the FluMu prophage.	25.00	25.00	33.00	32.60	23.80	23.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.09	0.71	-4.71	15	142	2009-01-15 18:05:59	2006-06-02 18:25:54	6	1	131	\N	25	118	1	179.60	26	94.11	CHANGED	hIsplEpAllsRl+p...shGshl+tVso.....................asGcaD-pslsplVRphPAlaVsatGts.ts...tsucs+apssupasVhVsucslsuEpssRhG...........lYQllpslpslLtsQcl....s.hshssLp..Pppl+sLa.ssphcspG...luVYAh-Fpssh...............l-.ssLsshphsptsh...................ts.ssDhpphtlphplsssps	.................................lsphEpAllsRlcp......hhG.ph.lpp.Vco.....................asGcas-.tsltphlt..shPAlaVsahGss.......tupsRhpssucaslhVs.ucslp....ucpssR.G............hYpllpplptlLsGpph...........t.ssslp...p..pl+..sla.sssh.t.stu...lulYu..l.Fssph...............s-.ssLcs..hth..tth........................................hst...................................................	0	11	17	23
+8706	PF08874	DUF1835		Domain of unknown function (DUF1835)	Bateman A	anon	PSI2 target BIG_63	Domain	This family of proteins are functionally uncharacterised.	21.10	21.10	21.10	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.70	0.71	-4.18	25	370	2009-01-15 18:05:59	2006-06-02 18:26:58	5	4	323	0	86	318	19	119.80	25	37.51	CHANGED	lHlshussAuuoL+hAltp.t..hs-pVlsltD-LSlGPlhslcstt.thtRtpW...l.ptht.t.......pp.htpp......hhschcsthpp...lppl..ssss.plslWpucsup-plsLphlhhhLpsps.p..lphlssop	...........................lHlshusssuusL+hhltptt............hpcs.Vlsh.p-s..holGP.l.t.p.lc.s.s.t.h...htRtpW......l.pslst......................t.hpp-.......hhschcp.phpp........L.cpl..ssps..plslW.pup.sup-plhLphlhtpLc..spt.p...lp.lphs.................	0	22	51	66
+8707	PF08875	DUF1833		Domain of unknown function (DUF1833)	Bateman A	anon	PSI2 target BIG_61	Family	This family of proteins are functionally uncharacterised and are  predicted to adopt an all-beta fold [1]. They are often found in gene neighborhoods containing genes for an NlpC peptidase and a  Ubiquitin domain predicted to be involved in tail assembly [1]. 	20.60	20.60	21.60	21.40	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.49	0.71	-5.05	12	139	2012-10-02 17:50:33	2006-06-02 18:33:47	6	1	118	0	27	137	7	147.30	21	88.56	CHANGED	shhcphtusssschhltslEIp+sshsc......shhlVpshcDlssphEs......Gp.l.FhAhsh-lslPspssuss.slplslDNVsptlschl-tuhtsp..h.tlshRhYLsschssPp.-hshphslpsssh-shplospAGhhDlhNpthsphpa	...........................tth.ttsssph...lpslElsHPshsp..............shh.ls.p......s......hc.s.lss.ptcs..............Gp...hhatshshsl.shPsps.sststslshslsslss.l.sstlc..pshts...p.........h...plsaRhY.....lu.scls..sPt.thshshplpssshs..stslshpss.h.shhspth..........................................................	1	5	10	18
+8708	PF08876	DUF1836		Domain of unknown function (DUF1836)	Bateman A	anon	PSI2 target BIG_64	Domain	This family of proteins are functionally uncharacterised.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.51	0.72	-4.28	48	1171	2012-10-04 14:01:12	2006-06-02 18:36:12	6	2	876	0	118	656	3	95.50	36	57.32	CHANGED	.php-l...Psl.............DLYhDQVlphhsphhps..................................th.....chLTpTMINNYsKp...pllssPpc.KK..Yo+pplshLllIthLKsllolp-IpplLphhhss..........hshcphYpta	..................................................php-lPsl.............-LYhDQVlthhsphhss.................................h....p..phLTsoMlNNYVKp...thls...tP......K.....KK.....YsppplshLlhIshLK.s.l.holp-Ippslphltsp..........hs.pphYp..h.....................................	0	45	84	98
+8709	PF08877	MepB		MepB protein	Bateman A	anon	PSI2 target BIG_66	Domain	MepB is a functionally uncharacterised protein in the mepRAB gene cluster of Staphylococcus aureus.	21.80	21.80	22.60	29.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.44	0.71	-4.59	14	546	2009-01-15 18:05:59	2006-06-02 18:40:34	5	1	530	0	56	301	2	119.70	49	79.89	CHANGED	EppNs-Ycuhhhplppcp..h+hRlAKhTPsKhGhFVsFWcK.spsspNpPFshp-ss-hLlI.slhDcsppG.FlFPK-lLlcpGILpopsppGKMAhRVYPsWspsLNppApKTQpWQhpYFh-h	........EK.Np-Y-uhhFphppcs...hpsRLAKKTPpKtGYFVohWpK...D.c.s.s.pN..pPas....hcshsDhLhI.sV..........hD..-......p.....ppGhFlFP+ElLlc+sILsopppKGKMAhRlYPpWsss........LNppAppTQcWQhpYFh-............	0	24	37	50
+8710	PF08878	DUF1837		Domain of unknown function (DUF1837)	Bateman A	anon	PSI2 target BIG_65	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	25.40	25.20	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.30	0.70	-4.76	59	272	2009-01-15 18:05:59	2006-06-03 10:19:05	6	3	262	0	46	206	4	214.50	17	69.97	CHANGED	cphschlhstlscaulsp................pc..hpphtppphtthht............putpph........................sphtppG...E.hGEll.Lahllcphhss......llsKh.hKss..p.thcGsDulHlthpsst......pLahGESKh..Yss...hssA........lpsshculpphh........ppsthpp-hpllpsphp.p.........t.t.tptlpchls.spps.........pphphphshshhlsa-sshh.ph.t............tpchpcplppphppphpphtp.............hp.tthtphphplhllPl	......................................................h...l.phhhs....................c....htth.htp..h.tthht..............htphh............................stphcsG...-..lGEll.ltthl.cthh.s...h.s....h.l..s+lthKss.pshsh+GsDslthh..hs..spst......plhhuEuKh.....hts...hpsu..........lpcshsslpcp...........ppp.hspphphlpsplppp.........p.shtctlcchlp.....................tt....hthshhhhhp.t.....................th...h...h..........................................................................................	0	11	29	37
+8711	PF08879	WRC		WRC	Riano D, Finn RD	anon	Manual	Domain	The WRC domain, named after the conserved Trp-Arg-Cys motif,  contains two distinctive features: a putative nuclear localisation  signal and a zinc-finger motif (C3H). It is suggested that  the WRC domain functions in DNA binding [1].	21.30	21.30	21.40	21.70	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.59	0.72	-4.29	25	422	2009-01-15 18:05:59	2006-07-26 15:40:26	5	12	32	0	213	410	1	45.50	49	10.33	CHANGED	-sEstRC+RTDGKKWRCs+pshsspKaCE+Hhc+u+pRsp+phcs.s	.......sEPuRCRR....TDG.....KKWRCS+cshs.spKYCE+H.h...pR...G..R....pRS+K.l-..t..............	0	23	124	179
+8712	PF08880	QLQ		QLQ	Riano D, Finn RD	anon	Manual	Domain	The QLQ domain is named after the conserved Gln, Leu, Gln motif.  The QLQ domain is found at the N-terminus of SWI2/SNF2 protein,  which has been shown to be involved in protein-protein interactions.   This domain has thus been postulated to be involved in mediating  protein interactions [1].	23.30	23.30	23.70	23.30	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.04	0.72	-7.66	0.72	-4.54	43	563	2009-01-15 18:05:59	2006-07-26 15:44:28	6	26	209	0	287	521	0	36.80	41	3.82	CHANGED	ssFossQhppLcpQhhsaKhlsp.....shPlPscLhhslpp	....sFossQhppL+tQlhsYKh.Lup.....utPlPspL.hslpt.....	0	51	141	221
+8713	PF08881	CVNH	CNVH; 	CVNH domain	Bateman A	anon	Bateman A	Domain	CyanoVirin-N Homology domains are found in the sugar-binding antiviral protein cyanovirin-N (CVN) as well as filamentous ascomycetes and in the fern Ceratopteris richardii.	22.10	22.10	22.80	22.40	21.90	21.90	hmmbuild  -o /dev/null --hand HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.47	0.72	-3.81	34	277	2009-09-10 22:09:16	2006-07-26 15:50:08	5	8	82	44	218	294	10	104.10	24	56.75	CHANGED	sFppSuccI+l.....pssphLsAcspsssG.p....hhsucIcLsphlGNss........GpFhW....................................................................sGtNFoco..Acslcht...ttptsslLcApLtsscGphtspp.lsL.sE+IsNpsGpLpa	..............................Fttosp.shpl....................ssp.hLtApC.p...st..s..G..p..........hh.p.o.pl-.LNph....lG.Nss....................Gph..ph............................................................................s.s.ssFspo..s..pshplp..............ts.h.L...pup.h.......ts........p..G..t...h....h......tsp....lsL.....s.c....pl.t.NtsGpL...........................................................	0	29	118	190
+8714	PF08882	Acetone_carb_G		Acetone carboxylase gamma subunit	Bateman A	anon	PSI2 target BIG_95	Domain	Acetone carboxylase is the key enzyme of bacterial acetone metabolism, catalysing the condensation of acetone and CO(2) to form acetoacetate.	20.80	20.80	21.30	37.70	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.52	0.71	-4.05	24	126	2009-01-15 18:05:59	2006-07-26 15:56:01	6	2	113	0	52	118	9	111.40	52	68.55	CHANGED	Vshs-hllLsLuschalsps...........CGHcFushRcNaKhtshlasRDscEhhptl.....YsthhAPDspWppIhEYYCPpCGshh-sEhssPhaPllHDhEsDI-uhhpcWlt	.............VsacD+IlLPLGsHLalVQssp.p+..hll+C.pCGHsFsssc-NWKL+A.IYVRDTtEthcEl.....YPclhAPDspWQVhREYhCPsCGhhl-VEAsTPWYPVlHDFEPDI-sFY+-WL.G.....	1	17	31	44
+8715	PF08883	DOPA_dioxygen		Dopa 4,5-dioxygenase family	Bateman A	anon	PSI2 target BIG_92	Domain	This family of proteins are related to Swiss:P87064 a DOPA 4,5-dioxygenase that is involved in synthesis of betalain. DOPA-dioxygenase is the key enzyme involved in betalain biosynthesis. It converts 3,4-dihydroxyphenylalanine to betalamic acid, a yellow chromophore.	25.00	25.00	33.20	32.80	23.50	21.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.61	0.72	-3.95	44	382	2010-01-08 13:27:16	2006-07-26 15:58:34	6	3	347	6	160	314	37	105.30	39	76.16	CHANGED	YHAHVYF...c.tsshptApsLpcpltccFs.......lphG..+l+p....+sVGPHP...hh.aplsF.ssc.FspllsWLtlsRssLoVLlHP.T.G-...-LtDHT.cpAhWLGcplsLslshh	.........aHAHl.YF..........s.ssptphAptLpcpltccFs..............lplh.....phap......................+.VGPHP...th.aplsF....ssspa.ssllsWLslsR.GsL.oVLlHPsT....G-..............-htDHp.-pAhWlGcshsLshshh.......	0	36	83	130
+8716	PF08884	Flagellin_D3		Flagellin D3 domain	Bateman A	anon	Bateman A	Domain	This domain is found in the central portion bacterial flagellin FliC.  The domain contains a structural motif called a beta-folium fold [1].  Although no specific function is assigned to this domain its deletion leads to a reduction in filament stability [2].	21.40	21.40	21.40	21.40	21.10	20.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.34	0.72	-3.80	34	687	2009-01-15 18:05:59	2006-07-26 15:59:46	6	4	182	3	5	483	1	88.90	36	20.39	CHANGED	ushshouhs..ssslKsus.............ss...ssussuspsuclhaDs.sscYYlcVsuhst...su+sGaYcVsVss......sGpVohsssssp..tsstPs...usspVTpsQ	..............................s.T.shouhs..sssIKAus................Gu...ssuTssstsuslpFcs..ssKYYspVsGhss...suKsGhYEVsVss............sGpVohsussTp...sshPs...usoslTcsQ......................	0	1	1	3
+8717	PF08885	GSCFA		GSCFA family	Bateman A	anon	PSI2 target BIG_88	Domain	This family of proteins are functionally uncharacterised. They have been named GSCFA after a highly conserved N-terminal motif in the alignment. Distant similarity to the Pfam:PF00657 lipases suggests these proteins are likely to be enzymes.	25.00	25.00	29.90	29.50	22.50	19.80	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.72	0.70	-4.83	49	313	2012-10-02 11:02:24	2006-07-26 16:17:02	6	8	248	0	91	323	73	208.60	32	70.18	CHANGED	splhshGSCFApplGctLptttapsh..........................sssaGs.lYsstslhphlppuhspp..s....tpslatts...s+aash...shsshuhsotpclhpphspplp..........ps+ptlppushllhTLGhs.sappppssplhssC.tlsptpFscch.....holsEIhpshpthhshlpsl..NPpl+llhTVSPV.hht.......cshsuNphSKusLhsAsppl...sp................pp..s.cs..........tYFPSYEIlh.sphpchpaYssD...hhHssptuVsalhcpF	.....................p.plhhhGSCFApplupthttt..taph............................ss.aGh.lasPhul.phlpphhtt..........ttthh...t............thahs....tht..s..s.tthhtthpttht..........thtphh.phshhllTLGoshsah........pps.......utl...ls.NCpp.h.stp.Fpcph.....lolpEhhpshpthlphltth.......NP.ph+llhTVSPlRahp.......cshhtsphSKusLhhAhcplhp..........................t...p..ps.............hYFPuYEIlh..DcLRDYRFYtpD...hhHsst.ulpalhcpF..................	0	29	64	78
+8718	PF08886	GshA		Glutamate-cysteine ligase	Bateman A, Eberhardt R	anon	PSI2 target BIG_70	Family	This is a rare family of glutamate--cysteine ligases, EC:6.3.2.2, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria [1]. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase.  The structure of this family has been solved, and is similar to that of human glutathione synthetase and very different to gamma-glutamylcysteine synthetase from Escherichia coli.	25.00	25.00	77.70	77.60	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.23	0.70	-6.16	27	271	2009-09-11 17:05:15	2006-07-26 17:16:03	6	1	265	1	85	225	152	400.70	57	94.39	CHANGED	Ec+lLsppssIEcWFRtpWpcassPFYsSVDLRNuGFKLAPVDTNLFPuGFNNLsPphhPLslQAshuAlp+.hCP-A+plLlIPEsHTRNtFYLpNVstLppIhppAGhpVRlGSlsspIscsTslpLssGpplslEPLhR...sssRLul.csFsPCsILLNNDLSuGlPplLpsl.-QhllPPLHuGWssRRKSpHFpsYccVup-FucllsIDPWLINPhFspCsslsFtsppG.EsLAspVDslLs+IRcKYccYGIc-cPFVlVKADsGTYGMGlMoV+suc-lhsLNRKpRNKMuslK-Gh.VscVIlQEGVhThEphss..AVAEPVVYMlc+aVVGGFYRlHssRGtcENLNuPGhcFhPLuFppss.hPp.tt..Psss........................sNRFYhYGVlARLAhLAAuhElc	......Ep+ILsspssIEpWFRhpWpcHsPPFYsSVDLRNAGFKLAPVDsNLFPGGFNNLsP-hlPLAlQAA.uAl-+.hCP-AKslLlIPEs.....HTRNsFYLpNVttLspIh+pA.GhpVRlGSLsPpl...sEsTplpLssG.ppllLEPLhR...spcRlu..........L....c....s...FsPCsILLNNDLSAGlPsILcsl.cQhlLPPLHuGWssRRKSsHFusYccVApcFAKllsIDPWhINPYFspssGlDFpt...+pGc-sLAcuV-tVLpKIpcKYcEYGIs-+PaVlVKA.DAGTYGMGVMoV+susEltsLNRKpRs......KM.utsK-GLtVo-VIVQEGVYTaEpl......ss....AVAEPVVYMhDRaVlGGFYRVHsuRGtDENLNAPGMcFVPLuFpps.shPDsptc..PsAs.........................sNRFYhYGVlARLuLLAASlELE.............................	0	18	52	68
+8719	PF08887	GAD-like		GAD-like domain	Bateman A	anon	PSI2 target BIG_90	Domain	This domain is functionally uncharacterised, but it appears to be distantly related to the GAD domain Pfam:PF02938.	25.00	25.00	33.90	33.50	24.60	23.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.13	0.72	-3.98	14	185	2012-10-01 21:10:01	2006-07-26 17:18:58	6	2	130	0	28	187	5	100.20	28	50.71	CHANGED	DcsaphhLcpFG.shcpp.lssus.I..-+Y+s+LP-tLLcYWp-cGWsuau-GlFWhVNPp-YcsllssWltGs.hhst-sh+llARoAFG-lalWuEpsuhslplsshhs	...................................tp.hstp..I..c+Yc.st.LPspLlphWpcaGausahsGhhtllNPp-Yp....sllpphh.................ctc.shhslhpoAFGDlhhWtcppsh.........h................	0	5	12	19
+8720	PF08888	HopJ		HopJ type III effector protein	Bateman A	anon	PSI2 target BIG_86	Domain	Pathovars of Pseudomonas syringae interact with their plant hosts via the action of Hrp outer protein (Hop) effector proteins, injected into plant cells by the type III secretion system. The proteins in this family are called HopJ after the original member HopPmaJ [1].	21.30	21.30	21.50	22.80	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.43	0.72	-4.06	39	245	2009-01-15 18:05:59	2006-07-26 17:21:56	6	2	245	4	74	224	31	109.60	47	92.81	CHANGED	M.......slp-...hlppLpspspplpFs-ThslI-ppYcaoPsuFpNG.s...lhNpAGpNpGSCKlFuFAplpsLocppTLtsFGpaYR.-VLtsPcGsDHtNIRsFh.p...pGWsGlpF-spsL	..................lpshlspLps..pphpFsDslAhI-spYsasPsuFpNG....s.....hpNsAG.pNpGSCKlFuFApLpuLopppTLtsFG-aYR.sVLssP-GsDHtNIRsFh....p....pGWsGlpF-upsL....	2	22	45	63
+8721	PF08889	WbqC		WbqC-like protein family	Bateman A	anon	PSI2 target BIG_75	Family	This family of proteins are functionally uncharacterised. However it is found in an O-antigen gene cluster in E. coli [1] and other bacteria [2] suggesting a role in O-antigen production. Feng et al. suggest that wbnG may code for a glycine transferase [2].	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.34	0.70	-4.89	67	583	2009-01-15 18:05:59	2006-07-26 17:27:58	6	4	429	0	184	571	435	164.00	24	92.01	CHANGED	QPhahPalGYFphlspsDpFllhD-spa.p+pu..WhNRNpI.tssp..........G.phlTlPlp.......cspppp.pIp-hplssst..Wpc+phpslppsY.u+APaF.cphhshlcslap..pp.ppLschNhphlphls...chLuI..psplhhoSchph....stppsc..+llslspphuAspYlsu.uupshhp.p.....Ft.ttulplpahpht.h.tYsQ..hts...t.FlPslSIlDlLhssG.scshphlh	...............................................s.ahs.htaa.ph.lhth..-...hhl..pp.pa....+.ps..ahNRshI...hs.s.p..........u......hlolPl.........p.t...p.....hp-hplssp.........Wtph+hpsl.pt.sY.tpuPaF.p.h.s.ht.hht.....pphp.L.phN.phhphlh...ph...lt.l..p.p.h..opphth........tt.p.h..ht.tt.......................................................Y.Q.....t......F.stlSllDllh..u..pt.....h.................................	0	65	135	164
+8722	PF08890	XkdN		Phage XkdN-like protein	Bateman A	anon	PSI2 target BIG_83	Family	This family of proteins are functionally uncharacterised. They are found in prophage sequence in various bacteria.	22.30	22.30	22.30	24.80	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.68	0.71	-4.42	23	222	2009-01-15 18:05:59	2006-07-26 17:31:39	6	1	160	1	58	199	8	132.50	24	93.15	CHANGED	slp-...hlhpphhpp.ch..p..shhcRhss..G..l.aph+ulotcchscl+ccsTpppphht.......thppchDpscapupllhtuslpPs....hpsp-Lpcuass.ssc.Ell++h...L.hsGEhsslsspltElsGa.-ssh--...lEE...hK	...........................................................................hh.tphhtt.ph....p..hhh.cRhh....p..s..t.h.hpl+sloscchpclccpssphpt.ht...............thhpchDpp.pa..sp..llhpus..l.P-......................hcspELp.....c.u.....a.....s.....s.h.s.st.-ll+ch...L..hsGEhsslhstl.-lsGa...sp..p.......hp-...l.-E.hK.............	1	29	49	51
+8723	PF08891	YfcL		YfcL protein	Bateman A	anon	PSI2 target BIG_80	Domain	This family of proteins are functionally uncharacterised. THey are related to the short YfcL protein from E. coli.	25.00	25.00	25.70	25.30	22.60	22.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.76	0.72	-4.00	29	716	2009-01-15 18:05:59	2006-07-26 17:33:15	6	1	710	0	84	220	6	86.50	67	94.87	CHANGED	ltcaEppl.shIDshVppuoD.DELFAuGYLRGHluLulAphE.cspp.slcsLcs+lppSLppA..puELussDpsLVpshWppLttp	......IAEFESRILALIDs..MV-HASD..DELFASGYLRGHLTLAlAE......LEu....uDDH.Ss.pAV+ss....VSQSLEKAIuAGELSPRDQALVssMW-sLFpp....	0	8	27	55
+8724	PF08892	YqcI_YcgG		YqcI/YcgG family	Bateman A	anon	PSI2 target BIG_93	Family	This family of proteins are functionally uncharacterised. The family include YqcI and YcgG from B. subtilis. The alignment contains a conserved FPC motif at the N-terminus and CPF at the C-terminus.	20.80	20.80	21.20	20.80	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.49	0.70	-4.78	34	324	2009-01-15 18:05:59	2006-07-26 17:39:34	6	3	265	0	87	286	8	212.20	33	84.71	CHANGED	pptacpFpptlts.....ssFPClhuppuhppspL+hsFhs..p.tptpsspplspsLtcalct.cshs.phs...SLllhFcss......pphohppacchhWphLppLpptDs...psWPpclPsDPccspWpFsFuGcshFlhsssPua..tpRpSRphsh.hhlsFpPRhlF-cl..psssp.hup+h+ctIRpRlttaDshshpPpLutaGt.-spEW+QYhlp--sp.............scCPFptt	..............................t..tappFpphlh-......sFPChhuhpuhppsplRYsFls......ppshpclspslhpalchh+-p...s.hhp......uhhlFhcs.......cctol-tacchaWplLphL+cpDs...psWPppIPpDPcc.tWEFsFuGEPhFlhsssPua..ppR+oRp.h...us...hhlsFQPRtlF-s.l..puspt..tupph+phlRpRlppaDp.hPhHPsLupYGs.cppEW+QYhltD-.p..........h.u+CPFp..h....................................	0	22	54	70
+8725	PF08893	DUF1839		Domain of unknown function (DUF1839)	Bateman A	anon	PSI2 target BIG_68	Family	This family of proteins are functionally uncharacterised.	20.50	20.50	20.70	187.00	17.90	20.40	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.91	0.70	-5.46	13	104	2009-01-15 18:05:59	2006-07-26 17:48:32	5	1	96	0	42	97	5	312.40	50	90.29	CHANGED	hsshs..scshssHuLHus-tlWsETNCYlDLWIELLHuhGLsPhAALuFTVsQDFEGDQFTFFKaP.tDLEpLYGlsVpELAlYDsLEsHVtsQlsRG+lVLlEVDSYaLPDT+GsuY+ccHsKTTIAIDhlDs-AptluYFHssGYHphpGEDYcGlFph.sshppsss.hhPYsEhsKpstsshspssLhcAShsLLRpHLsRRPcpNPlstFRpsFstcl-plhsRs.saFHhYuFNsLRQLGANFELhu+aLcWLstpGpssPts..supustoIAoEAKVlQFRLARAVhR+KsDsspssLDsLEsAappslsuLApp	.......ht...cscpYcPHsLHusphlWppTNCYVDLWIEVLthhGLsPhAALsFTlo.DFEGDQFTFFKaPhEDLEpLYGIhVQEhAIa-sl-sHVEpQlAR...GpLhLVEVDuaaLPDTRGsoY+ppHsKTTIGIDsIDhptRpluYFHNuGYahh-GtDYDGLFtt.ssht........LhPYVEhAKRph.t.PL-.cptLs-sShsLLp+HLpRRPssNPIsAFRpthstcscslAsp.....PhsaFHtYoFNoLRQLGANFE.Lhu+YLcWLpssGtsuP.h......s........hssAscpIASEAhVlpFRLARAsuRuKp-cscusLDhlEpAassllsslut.h......	0	4	16	25
+8726	PF08894	DUF1838		Protein of unknown function (DUF1838)	Bateman A	anon	PSI2 target BIG_43	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	50.30	26.70	21.20	16.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.74	0.70	-5.15	9	37	2009-01-15 18:05:59	2006-07-26 17:54:37	6	2	34	0	19	34	76	224.60	36	82.65	CHANGED	cupslaahWpGplauhhsGE..cc+LFsl.GMsls+Chshs-ut....uachloRElhhYhDPpTG-lLcpWcNPWoscsVsVlH.............VANDPVp.............uhhptphsh..tG-phsashsl.LhYPNPLus-.Qht...sGshYpAsELFphhsspssLtss-sso.ssspluWsRlusWLPWMtMG.sR.GhLhapstGpKlsSh--Ls.hhpppIss+hPhYtpsPcphs-t.N.TSWhYF+phhc	........spplhahWpGclYuhhPGE...chLFthcGhNVu+sl.ps-ut.t..uachloRElhhYh......DPsTsElLcpWcss...t.ssVlH....................VhNDPss....................................................tthh.h.hshp..hGsphshshpl.LtYPsPLss.hQh.......sussYcAhELFpahsspssLt.sst.ss..ssphuWsRhusWLPWMthG.sRsGhLhapstGpKls.uas-lPthhps.IsschP.atpsPpphs-.sN.TSWhaF+ph.................	0	8	14	18
+8727	PF08895	DUF1840		Domain of unknown function (DUF1840)	Bateman A	anon	PSI2 target BIG_69	Domain	This family of proteins are functionally uncharacterised.	25.00	25.00	25.70	34.00	23.10	24.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.43	0.72	-4.01	41	231	2009-01-15 18:05:59	2006-07-26 18:01:24	6	2	210	0	91	204	18	103.90	36	96.15	CHANGED	M.LlTF+S+AsuDlhMht-lApplLpllG+.......ssss.GsIss--lPsAlppLcsAl....tuppstssssp...........pppccstctsluLuQRAhPLl-hL+tAtc..pss-VhW	......MllTF+S+AssDlsMhcDhAhhlLtllGK.......phs.cGlIos--lssAIs+L-sAlstt.ptptppssp.p........................tsctccppp-.sluLuQRAhPhlcML+pAtt..pss-VhW.....	0	15	47	72
+8728	PF08896	DUF1842		Domain of unknown function (DUF1842)	Bateman A	anon	PSI2 target BIG_72	Domain	This domain is found at the N-terminus of proteins that are functionally uncharacterised.	20.20	20.20	20.30	21.60	20.10	17.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.38	0.71	-4.35	17	105	2009-01-15 18:05:59	2006-07-26 18:20:34	5	2	61	0	24	64	0	115.10	44	60.12	CHANGED	sGLFsspYhl.....ussh.GAPsLpLsLLVsTsc+pVsGpApIoQusp.PPlshcucVWGpao.htl.ss....upspIlloLpGs......uGPtSs.ht.sF+LchlLssDWps...GsAsYcYh.psGpW	.............sGLFPVpahV.....uTsh.GAPsLhLsLlVsT.s-+oVsGhA..p..ITQ.uVs.PPLsF+AcVhGsas.htl.P.....ussplhloLpGss.......uGPhusthh.sFclchlLsssWpo...GsAoYRYa.psupW..........................	0	4	7	12
+8729	PF08897	DUF1841		Domain of unknown function (DUF1841)	Bateman A	anon	PSI2 target BIG_71	Domain	This family of proteins are functionally uncharacterised.	21.00	21.00	21.30	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.35	29	307	2009-01-15 18:05:59	2006-07-26 18:20:47	6	1	298	0	91	253	52	132.80	45	88.24	CHANGED	PoR-pl...RpFFh-sWpKtpsspsLosLEshAschItpHPEYHshLp.ssEstLspDYsPEtGpoNPFLHLShHLuIpEQlSIDQPsGIRssacpLst+.hss.H-ApHphMECLuEhlWpAQRsGssPDsssYlpslccp	.............................spc-V...R+FFhcsWpKphssp.LosLEthAschIttHPEYHt.Lp.sh-p.tlsp-ah......PEpG....coNP..FLHlShHLuIpEQluIDQP.GIRssa-pLsu+..sshH-ApHt..hMEsLuEtlWpAQRt.Gps.PDsssYlsplp+.h...	0	22	55	74
+8730	PF08898	DUF1843		Domain of unknown function (DUF1843)	Bateman A	anon	PSI2 target BIG_72	Domain	This domain is found at the C-terminus of a family of proteins that are functionally uncharacterised. The presumed domain is about 60 amino acid residues in length and is found independently in some proteins.	21.70	21.70	21.70	48.10	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.49	0.72	-3.93	15	126	2009-01-15 18:05:59	2006-07-26 18:24:54	5	3	42	0	24	71	0	53.00	56	33.94	CHANGED	PhYGVAIQpAhASGDLupMKuLsupA-pQLsptsplpsAlptLcsEIARLEtR	.shYGVAIQpAtASGDLu+MKoLustAcpQLuspspIAuALptLcsEIAKLEuR.	0	6	12	15
+8731	PF08899	DUF1844		Domain of unknown function (DUF1844)	Bateman A	anon	PSI2 target BIG_76	Domain	This family of proteins are functionally uncharacterised.	20.70	20.70	21.70	21.30	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.25	0.72	-4.06	18	82	2009-01-15 18:05:59	2006-07-26 18:29:23	6	1	81	0	54	80	123	74.50	40	62.58	CHANGED	plsFssFlhSLuoSAlhpLG-hPcPpoGphpc.sL.h.......A+poIDlLuMLpEKT+GNLos-Es+lL-slLh-LRh+Y	.........lsFssFlhSLsooAhspLGchssPp.oGphpp.sL.h........A+....poIDlLsMLpEKT+GNLss-Ep+lLcslLa-LRhpY..	0	33	46	53
+8732	PF08900	DUF1845		Domain of unknown function (DUF1845)	Bateman A	anon	PSI2 target BIG_78	Family	This family of proteins are functionally uncharacterised.	20.40	20.40	20.40	20.70	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.27	0.70	-5.05	25	252	2009-09-11 12:10:13	2006-07-26 18:32:17	6	2	206	0	69	241	11	209.90	34	82.41	CHANGED	ptphGuL..RSslslsLHTpaAhRLWp.GRptpcscp.............uIhGhssahuhhsplppu.uppDDPYADhallplEcpltpucpplpphspplcthhsp.lPsslslucstSlpPlplsLahsosLGapsVaLLscaDpLspplhpApHhuLlu+pctpchlcpGu+hlRplFulsQpY.......RasGloRcDht..tsNA+uppA...lc+hG.clPt-lLpGp+RSs..FuP..lsps	...........................................p..phGuL..+SshslsLHT+aA.RlWp.GR...tttcscs.......................sIlGhstalshhsphpps.utpDDPYuDhhhlplEcclppsp....pphpslt.ppl-phhus.lPsslslucshslp.....Plp..lslalsssLGapsVaLLssaDpLs++lhhApHhuLIs+sphc.p....hLscGu+hl....RplaulsppY.......+.hsGsoRsDht.....tpNutuptA......hcchG..clPp-lLpGp+RSp..FuP.sl...p...................................................	0	11	34	54
+8733	PF08901	DUF1847		Protein of unknown function (DUF1847)	Bateman A	anon	PSI2 target BIG_82	Family	This family of proteins are functionally uncharacterised. THey contain 4 N-terminal cysteines that may form a zinc binding domain.	25.00	25.00	28.40	28.20	21.60	20.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.01	0.71	-4.72	31	185	2009-01-15 18:05:59	2006-07-26 18:49:59	6	2	169	0	70	167	5	151.60	44	73.44	CHANGED	Csstp..tchlccshp.Yppc.pst+lupsAAplEuptY...........s+hTRlEElltFA++hGa++lGlAhClGLhpEu+lhscILcspGFElhSVhCKsGul-KsplGltcp...p.sshEuhCNPIhQAclLNctpT-LNlllGLCVGHDhLFhKaScAPlTTL	...................C.s.t....c.hppshphYpp-.pst+ltpsu.AplEuphY...........sc.hTRlEEllpFA++hGaKKIGlAhClGLhcEA+hhscIL.ctpGFE.lhSVhCKsGulsKsp.lGltcp....p.s.shEshCNPIhQAclLNctpT-LNlllGLCVGHDoLFhKYScAPlTTL...........	0	27	49	61
+8734	PF08902	DUF1848		Domain of unknown function (DUF1848)	Bateman A	anon	PSI2 target BIG_74	Family	This family of proteins are functionally uncharacterised. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of Pfam:PF04055.	24.80	24.80	24.90	29.80	23.90	24.70	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.78	0.70	-4.86	33	307	2009-01-15 18:05:59	2006-07-26 18:54:42	6	1	280	0	86	291	10	258.50	39	84.80	CHANGED	IISASRRTDIPAFYu-WFhsRl+cGaVhVpNPass+ploclsLpPcsVDulVFWTKNPtPhl...shLsElcshuasYYFpFTlTsYspp.lEPsl.....Pshpp.tlcsFppLSctlG.-RVlWRYDPlllosp..hsh......caHhcsFpplAstLs..GaTc+ClISFlDh..YpKscpshppls.....hh.psspc....chtplupphupI.....Apca.ulpLpoCu-chs.LsthG...ItpupCIDtpllccl.....hGpph...........................thtK.D+uQR..ptCGChcSpDIGsYs..TChHGClYCYA	.........................IlSsSRRTDIPAFYucWFhsRl.+..pGalhVpNPaN.pplo+lsLss....csVDslVFWTKNPtP.hl...spLppLpp....a.t.aYFpaTlTsYsc-.lEssl......Ps.hp.c.hlc.sFpcLSc.tl...G.tc..+llWRYDPIl.losp...hsh........paHhctFppluppLp..Ga.Tc.+sllSFlDh..YpKsppshtpht....................h.th.spc..........chhplupphscl.......Ap..p..a.....sl..plpoCuEphc....Ls.thG....lpputCIDtpll.ccl.....hGtp.l.........................................phtK..DpsQR..ptCuChtSh.DIGsYs..T.Ch+GChYCYA........................	0	43	70	78
+8735	PF08903	DUF1846		Domain of unknown function (DUF1846)	Bateman A	anon	PSI2 target BIG_73	Family	This family of proteins are functionally uncharacterised. Some members of the family are annotated as ATP-dependent peptidases. However, we can find no support for this annotation.	25.00	25.00	45.40	45.30	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.76	0.70	-6.04	22	660	2009-01-15 18:05:59	2006-07-26 19:20:06	6	3	644	4	66	448	23	479.30	62	99.14	CHANGED	+IGFDs-KYLchQScHIhERlspFssKLYLEFGGKLhDDaHAuRVLPGF-PDuKl+hLpcLKDpsEIlIsIsAsDIE+sKlRGDhGITYDpDVLRLIDsa+shGLhVsSVVITpYsu.QsuAshF+p+LE+hGIKVYhHYsItGYPo-lchIVSDEGYGKN-YIEToRPLVVVTAPGPGSGKhATCLSQLYHEaKRGlcAGYAKFETFPlWNlPLKHPVNlAYEAATADLsDVNMIDPFHLEAYGcTsVNYNRDVElFPVLpphhE+IhG.cSPY+SPTDMGVNMsG.sIsDD-Asp-AS+QEIIRRYapshs-htpstssccplp+lcLlMppsslospDRtVVssAhphA-cs............ssPusAlELsDG..pIlTG+TSsLhsuouAhlLNAlKcLAsIsc-lcLISPpsIEPIQpLKsphLGS+NsRLcs-ElLIALSloAsosssAphAhcpLspL+GC-sHoosILossDcpshRKLGlplTs-PhYpsp.pLYp	...........................K.uFDsEpYLphQp-HILERIsQ.F...D.GKLYLEFGGKhl-DaHAuRVLPGa-PDsKI+lLpcLK-QVElVIsINAusIE+sKsRGDLGIoYDp-VLRLIDpFp-hGlaVGSVVITQYsG.QPAA-sF+spLE+pGIcsYhHYsIcGYPoDh-+IlSsEGhGKNDYIcToRsLlVVTAPGPGSGKLATClSphYH-phpGl+uGYAKFETFPVWNLPL+HPVNLAYEAATADLcDVNMIDPFHLpsYGcTTVNYNRDIElFPVLKRhlE+IhG..cSPYtSPTDMGVNMVGFuIsDDEAshEASKQEIIRRYYpTllDaK.tpp.ls-ssVcKIELLMsclGlossDR+VslsARpKAEcT..............GuPAlAlELPsG..pIVTGKsS-LhGsoAAsLlNAlKphAsIs.cEl+LIpP-slcPIQsLKhcaLGS+NPR.LHosElLIALuIoAspNPsAtpAh-cLspL+Gs-AHSTlILocpDcslLRKLGIsVThDPhYphc+LY................	0	31	47	58
+8736	PF08904	DUF1849		Domain of unknown function (DUF1849)	Bateman A	anon	PSI2 target BIG_67	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	102.80	102.40	16.90	16.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.49	0.70	-5.05	26	192	2009-01-15 18:05:59	2006-07-26 19:20:35	6	1	186	0	65	145	128	251.00	40	87.83	CHANGED	usAtAAuussLssHRAlYDLsLtcopsptulsuhpGRhlY-Fs.GsuC-GYoscaRhVoplpss-sssploD.posoaEstcG+sa+FpscohsssphsppVcGsAcps..scshpVclcpPcscshsLs.tslFPTpHhhclIctAcsGcphhpsslFDGo-sucKshpTsslIGcstssssssssst.ts...........................................phsshstWPVTluYFs....ssss..-thPsYphSFcLaENGVoccLslDYuDFslsGpLucl-lhcsp	.......u.AtAuuuspLlPHRAlYDLoLscAsppoulsuhsGRMVYEFs.G..SAC-GYTosFRhVocls.s-pspcloDppoTTaE-uDG+sFRFhs+ohsscpls..ccVcGsAchp....sst.ssV+Lp+PcppolsLs.uo.FPTcHhtclIstAcuGp.phhpsslFDGS-cu-+lhsTosllG+tpss.ssscs.cs....s...........................................chuptphWPVTlAYF-......cppp....-thPlYchsF+LYcNGloRcLshDYGDFshpGcLscL-lhcp.s...	0	16	37	46
+8737	PF08905	DUF1850		Domain of unknown function (DUF1850)	Bateman A	anon	PSI2 target BIG_87	Domain	This family of proteins are functionally uncharacterised. Some members of this family appear to be misannotated as RocC an amino acid transporter from B. subtilis.	21.00	21.00	21.00	25.80	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.08	0.72	-4.17	50	249	2009-01-15 18:05:59	2006-07-26 19:21:19	6	2	241	0	113	252	29	90.80	25	58.67	CHANGED	pFoLpWsHSVE+spWpEsaplssss....LhLscschcuhGAGM.....csssssphcsGhahap.shs.shspls.ltsos..susapLshssp.....s.......hsLsp	.......FoltapHSVE+sthpEsaclssss....LhLtcs+hpuhGAGhs.......c.ss..sst.h.c.sG.hahhp..ht.sh..s..p..lp..ltsus..supaplshssp.....ph.l..t....................................	0	37	76	94
+8738	PF08906	DUF1851		Domain of unknown function (DUF1851)	Bateman A	anon	PSI2 target BIG_90	Domain	This domain is found at the C-terminus of a variety of proteins that are functionally uncharacterised.	27.40	27.40	27.40	27.70	26.30	27.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.40	0.72	-4.00	31	216	2009-01-15 18:05:59	2006-07-26 19:26:17	6	2	152	0	36	227	5	76.00	30	42.01	CHANGED	pphspplptFhhthpssph..s........hcs.....LFctAtccLG.LctDEhYGFsPALsLGGstslcsLpKlchhEHLhlLuQlss	....................................thp.Fht.hpspp.............hcc.ht..happAlc+h..G..LphsEhaGasPhLsLGGttcl-NLpKV+hhEHlhllsQl..s...........	0	11	20	28
+8739	PF08907	DUF1853		Domain of unknown function (DUF1853)	Bateman A	anon	PSI2 target BIG_96	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	27.30	27.20	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.85	0.70	-5.23	43	413	2012-10-11 20:44:44	2006-07-26 19:26:35	6	3	401	0	93	362	50	259.20	28	88.53	CHANGED	RDLuWhLtoPsLlssss.......................thhttaLpphDts..sssltphh................tsspR..LGhYhEpLhpahLp.....pssshcLlApNltlp.pps...pTLGELDaLl+s..sssphhHhElAlKaYLh..........ssssspt...........spWlGPNtcDpLcpKLs+lhp+QLsLuppstspthLsph......tssppplhhpGhLFhP..........hsssssssttlsssplpGhWhphc.-a.ths..........sttathLs+hsWLu..ssth..............sthhstpplpphlpphts............P.hlhth........tsthpEspRhFlV	........................................RpLsalltuPsLhpsts.................................tthhshLttL-t.s...stsLtcaht................ts..hR...LGhhhEpLhtahlp.....psP.thcl..lAtsl..tlp..ssG....pTlGplDFLlct.....tsp..p..h.HhElAlKaYLt..............................p..................ssahGPNspDpLstKhs+hhpHQL.Lopp..st...hhphh.th..............tshptphhlpGhLahs.................................stsshs...slsspphpGhWhptp.-.htths.................ttahhLs+.sWLsstph...................tts.h.tttth..................................................................................................................	0	16	47	75
+8740	PF08908	DUF1852		Domain of unknown function (DUF1852)	Bateman A	anon	PSI2 target BIG_94	Family	This family of proteins are functionally uncharacterised.	25.00	25.00	134.20	134.10	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.84	0.70	-5.65	27	294	2009-01-15 18:05:59	2006-07-26 19:27:27	6	1	290	0	85	262	19	317.50	70	97.96	CHANGED	Msp-FsFoIKsIpFDEsYpPS-sTRlTTNFANLARGcsRQENLRNsLpMIDNRFNsLAaWDNPpuDRYoVELEIISV-hcI..cGsupsFPhIEILKTsIlD+KTscRI-GIVGNNFSSYVRDYDFSVLL.-HNKspspFSsP-sFG-LHGKLFKpFlsSssY+ppFsKPPVICLSVSosKTYHRTtNpHPVLGlEYpQs.....EhSLTDpYFpKMGLpVRYFMPsNSVAPLAFYF..hGDLLsDYTNLELISTISTMETFQKIYRPEIYNANSsAGphYQPSLcaQDaSLTpIVYDREERSQLAlcQGKFsEEHFIKPYpslLEQWSAs	....MspcFTFoIKolpFDENYpPS.-sTRITTNFANLARGpsRQENLRNsLpMIDNRFNuLAHWDNPpuDRYoVELEIISV-hsI........cusupsFPhIElLKTsIVD+KTscRIEGIVGNNFSSYVRDYDFSVLL.-HNKspspF...SlP-sFG-LHGpLFKpFlNSssYKtpFpKsPVICLSVSos+TY+RTpNpHPVLGlEYpQs.....-hSLT-pYFpKMGLpVRYFMPsNSVAPLAFYF..hGDLLsDYTNLELISTISTMETFQKIYRPEIYNANSsAGpsYQPsL+ppDaSLTpIVYDREERSpLAl-QGKFsEEpFIKPYpslLEQWSA............	0	11	29	59
+8741	PF08909	DUF1854		Domain of unknown function (DUF1854)	Bateman A	anon	PSI2 target BIG_97	Family	This potential domain is functionally uncharacterised. It is found at the C-terminus of a number of ATP transporter proteins suggesting this domain may be involved in ligand binding.	21.30	21.30	21.30	29.70	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.45	0.71	-4.56	22	103	2009-09-11 14:44:06	2006-07-26 19:28:22	6	3	102	0	52	97	16	131.80	42	45.30	CHANGED	ps+-GVsPVRAFPIuAPscGluLlstDG+ElhWl-cLspLssssRtLlEp-LAsREFhPpIp+IpsVSoauTPSsWpVpTDRGpsphVL+GEEDIRRLsups.LLIsDscGlpahItDhssLD+cSRKLL-RFL	..................................sacuVsPVRAFPIosPscGlSLh....s.s-G+ElhWI-cL.s.cLssssRpllEp-LAtREFhPpIp+IhsVSoauo.PSsW..pV-TDRGtsph....sL.+.G.E.EDIRRL.sups.LLIsDscGlpahI.DhpsLD+pSRKlL-RFL......	0	11	33	48
+8742	PF08910	Aida_N	DUF1855; Aida_N; Aida-C2;	Aida N-terminus	Mistry J, Sammut SJ, Coggill P, Zhang D, Eberhardt R	anon	pdb_1ug7	Family	This is the N-terminal domain of the axin interactor, dorsalization-associated protein family [1].	25.00	25.00	25.40	27.00	23.70	19.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.56	0.72	-3.81	8	75	2011-09-20 15:42:39	2006-08-01 13:23:48	5	4	53	1	50	59	0	93.80	62	33.31	CHANGED	pls+Wpuuhc+usDFDSWGQLlEAlDEYQhLu+pLpKpspu.tsspsFTE-QKKhluKlATCLcLRSpALQs...Tuup-uhoL--lKKLcslLKsllsss.ctFPlcVp	..........h.lp+WtuSh++usDFDSWGQLVEAlDEYQhLARH....LQKEAQu.pNsS-FT.E-QKKTIGKIATCLELRSAALQS...TQSQEEFKLEDLKKLEPILKN.IL.TYN.KEFPFDVQ..............	0	11	16	27
+8743	PF08911	NUP50		NUP50 (Nucleoporin 50 kDa)	Mistry J, Sammut SJ	anon	pdb_2c1m	Domain	Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha [1].	22.50	22.50	22.60	23.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.57	0.72	-3.60	35	204	2009-01-15 18:05:59	2006-08-01 13:53:58	6	5	157	7	130	216	0	72.10	35	13.50	CHANGED	uKRsAscpLo+DNa..DpE..--.s-EsGoFppASpElLpsRtItKs+RRt....ss...........ssssstushssFuuhshsss	....................uKRhApppLoccNa.......DpE.....-p..s--sGo.FphASp-VLpsRt.ItK..s+R+p.....s.......................pssssush.psFpuhths..s.....................................	0	42	67	105
+8744	PF08912	Rho_Binding		Rho Binding	Mistry J, Sammut SJ	anon	pdb_1s1c	Domain	Rho Binding Domain is responsible for the recognition and binding of Rho binding domain-containing proteins (such as ROCK) to Rho, resulting in activation of the GTPase which in turn modulates the phosphorylation of various signalling proteins. This domain is within an amphipathic alpha-helical coiled-coil and interacts with Rho through predominantly hydrophobic interactions [1].	23.00	23.00	24.00	26.90	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.32	0.72	-3.67	22	184	2009-01-15 18:05:59	2006-08-01 13:56:02	6	18	68	4	94	144	0	67.40	56	5.32	CHANGED	LTpDluNLupEpEELNsKhKcupEchpphK-EE..hsslKAtFEKp...lpoER..TLKTQAVNKLAEIMNRK-	............................LTpDltpLspEKEELspKh...K.csp.E..c...hpthK-EE...hsslKApaEKp...LpoER..TLKTQ..AVNKLAEIMNRK-.	0	15	23	56
+8745	PF08913	VBS		Vinculin Binding Site	Mistry J, Sammut SJ	anon	pdb_2b0h	Domain	Vinculin binding sites are predominantly found in talin and talin-like molecules, enabling binding of vinculin to talin, stabilising integrin-mediated cell-matrix junctions. Talin, in turn, links integrins to the actin cytoskeleton. The consensus sequence for Vinculin binding sites is LxxAAxxVAxxVxxLIxxA, with a secondary structure prediction of four amphipathic helices. The hydrophobic residues that define the VBS are themselves 'masked' and are buried in the core of a series of helical bundles that make up the talin rod [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.58	0.71	-3.88	22	278	2009-01-15 18:05:59	2006-08-01 13:58:23	5	29	85	5	132	225	1	116.70	43	7.10	CHANGED	oFVDYQTTMV+pAKAIAVTsQEMhTKSsTsP-ELGsLAsQhTsDYupLAtpup.AAssAEsEE..............................................................IGh+I+pRVQ-LGHGCssLVpKAGALQssPoDuYTK+ELIECARcVSEKVSpVLAALQAGNR	.......................................................oFlDYQTphV+tuKuIAhoApEMs..spSss.sPp..-LusLA.....sphopD.as.pLsp..puh.AAusApspE..............................................................luhpI..+spVp-LGpus.tLlptAuALpssPs.DshsK+..........-Lhcs.ARsVoEKV.utVLuALQuGs+.......................................	0	32	42	78
+8746	PF08914	Myb_DNA-bind_2		Rap1 Myb domain	Mistry J, Sammut SJ	anon	pdb_1fex	Domain	The Rap1 Myb domain adopts a canonical three-helix bundle tertiary structure, with the second and third helices forming a helix-turn-helix variant motif. The function of this domain is unclear: it may either interact with DNA via an adaptor protein or it may be only involved in protein-protein interactions [1].	27.10	27.10	27.30	27.20	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.22	0.72	-4.17	11	164	2012-10-04 14:01:12	2006-08-01 13:59:53	6	13	122	1	117	163	0	62.50	33	11.24	CHANGED	GRluaT-tEDsAILsYV+EpuRuP.uoVoGNALWKtMEKspLTpHSWQShKDRYLKHL+GQc+chL	......RhsaTspDDthlhpalt....p.......tcps..ss.h...s..G.Nplapph.......pcp....p.................pH..oWQSh+-RYlK+Lptp..................	0	38	61	86
+8747	PF08915	tRNA-Thr_ED		Archaea-specific editing domain of threonyl-tRNA synthetase	Mistry J, Sammut SJ	anon	pdb_1y2q	Domain	Archaea-specific editing domain of threonyl-tRNA synthetase, with marked structural similarity to D-amino acids deacylases found in eubacteria and eukaryotes. This domain can bind D-amino acids, and ensures high fidelity during translation. It is especially responsible for removing incorrectly attached serine from tRNA-Thr. The domain forms a fold that can be be defined as two layers of beta-sheets (a three-stranded sheet and a five-stranded sheet), with two alpha-helices located adjacent to the five-stranded sheet [1].	25.00	25.00	41.10	40.30	23.70	18.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.87	0.71	-4.20	35	141	2009-01-15 18:05:59	2006-08-01 14:01:24	6	3	129	15	97	144	14	135.50	45	25.44	CHANGED	MRlLhIHuDhhcYcs+cKs.chAE-..tssppuch--sLVsFsuVE+sD-ps.p.llcpAlc-Ihcsup+lcssp..lllYPYAHLSSsLAsPpsAhclLcplE...ptL..tppshcVhRAPFGWYKuFpIsCKGHPLSELSRoI	..........M+lLhIHu-hhcacs+cKs.c..h..sE-...tp.cpsch--sLVsFhuVE+sD-ps.ttllcpAlp-IhclusplKsps..lVlYPYAHLSSsLusPcsAlclLcplE...ptL..tppshcVhRAPFGWYKuFcloCKGHPLSELSRsI........	0	28	58	79
+8748	PF08916	Phe_ZIP		Phenylalanine zipper	Mistry J, Sammut SJ	anon	pdb_1q2h	Domain	The phenylalanine zipper consists of aromatic side chains from ten phenylalanine residues that are stacked within a hydrophobic core. This zipper mediates dimerisation of various proteins, such as APS, SH2-B and Lnk [1].	25.00	25.00	30.00	35.20	23.70	20.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.79	0.72	-3.65	7	161	2009-01-15 18:05:59	2006-08-01 14:02:27	6	4	64	3	89	161	0	58.10	48	9.67	CHANGED	.uWpEFCELHApsAAtDhA+pahhFlppN..Ppa.sPhust.FSt+Fs-hF.paFpsElpc	.....uWcEFCEhHApAAAhDF.A++Fphal.......ppp..Ppa..ss.P.s.uts...uFS++Fs-h..FhpaFptEVt......	0	12	20	44
+8749	PF08917	ecTbetaR2		Transforming growth factor beta receptor 2 ectodomain	Mistry J, Sammut SJ	anon	pdb_1ktz	Domain	The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9) [1].	25.00	25.00	25.00	36.20	21.50	22.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.02	0.71	-4.33	6	96	2009-01-15 18:05:59	2006-08-01 14:04:18	5	3	46	9	38	87	0	110.20	54	22.61	CHANGED	lspLCKFCDVptooCsGpsoCtSNCsITSICEpP-EVCVAIWR+s-cNlTlETlCHcPphpLYGhhL-DtNoopCVMKE+pssuGphahCSCssE.ECNDhLlFs....s.p.sppppll	..........spLCKFCDVc.ooCcspcoChSNCSITSICEcspEVCVAlWRKND-NlTlETlCHDPphshHGa...hL-DssSsKClMKEKKssGpsFFMCSCss-.ECNDhlIFs...phssts........h.............	0	1	7	18
+8750	PF08918	PhoQ_Sensor		PhoQ Sensor	Mistry J, Sammut SJ	anon	pdb_1yax	Domain	The PhoQ Sensor is required for the virulence of various Gram-negative bacteria by allowing interaction of PhoPQ with the intracellular membrane, resulting in remodelling of the bacterial cell surface and subsequent bacterial resistance to host antimicrobial peptides. The domain contains a major flat acidic surface, which binds to at least 3 calcium ions, neutralising the domain's negative charge and allowing interaction with the negatively charged membrane [1].	20.30	20.30	20.30	20.50	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.98	0.71	-4.77	10	556	2009-01-15 18:05:59	2006-08-01 14:06:04	5	7	550	8	46	195	7	178.50	77	37.00	CHANGED	PFSLRsRFLlATAuVVLALSLuYGlVAlVGYSVSFDKToFRLLRGESNLFYSLAQWcNNKLoIslPPslDlNsPTLVLIYDEpGplLWRQRcVPcLEspIpsEWLc+sGaaELDTDscsSstlL.usNsphQcp...L+ch.-ssD-ssLTHSVAVNhYPATu+LPsLTIVVVDTIPQELQ+osl	....PLSLRVRFLLATAAVVLVLSLAYGMV.ALlG.YSVSFDKTTFR.LLRGESNLFYTLAKWENNKLpV..ELPE.N.l.DhQSPT.MT.LIYDEsGpLLWuQRDVPW.Lh.KhIQP-WLKoNGFHEIEuDVssTShLL.SsDHShQpQ...LpEV..RED.D...D.DAE.MTHSVAVNlYPATSRMPpLTIVVVDTIPlELKpSYM.....................	0	2	11	28
+8751	PF08919	F_actin_bind		F-actin binding	Mistry J, Sammut SJ	anon	pdb_1zzp	Domain	The F-actin binding domain forms a compact bundle of four antiparallel alpha-helices, which are arranged in a left-handed topology. Binding of F-actin to the F-actin binding domain may result in cytoplasmic retention and subcellular distribution of the protein, as well as possible inhibition of protein function [1].	22.20	22.20	24.30	28.80	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.48	0.72	-4.35	16	161	2009-01-15 18:05:59	2006-08-01 14:07:44	5	10	74	2	82	188	0	108.80	48	9.55	CHANGED	ssssploK-ulLElsphLcsulsphpss..s.h............hupahpLuDphppLashCssYs-s.hhsPHsKFpFRELloRLEsps+pLRs..suups......sssss+llscltsol+-IsslVQR	....................................h.uspIoKpslL-ss-.hL.......ssAIocsspp.....................hspaStll-sG+pLhsaCsuYVDs.I.QhRNKFAFREAlsKLEssLpELQl......ssAsAG.....sPusspshscLLSoV+EISDlVQR..	0	14	20	47
+8752	PF08920	SF3b1		Splicing factor 3B subunit 1	Mistry J, Sammut SJ	anon	pdb_2f9j	Domain	This family consists of several eukaryotic splicing factor 3B subunit 1 proteins, which associate with p14 through a C-terminus beta-strand that interacts with beta-3 of the p14 RNA recognition motif (RRM) beta-sheet, which is in turn connected to an alpha-helix by a loop that makes extensive contacts with both the shorter C-terminal helix and RRM of p14. This subunit is required for 'A' splicing complex assembly (formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA) and 'E' splicing complex assembly [1].	25.10	25.10	25.90	25.40	24.80	25.00	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.17	0.71	-4.17	25	284	2012-10-02 12:52:19	2006-08-01 14:09:09	5	8	240	9	211	279	8	155.20	40	13.15	CHANGED	sssspp+.+RSRWD...pTP......sss.sssss................s.hppsch..sp...sP.....upTPhs....sp....................uhsTPhsspp..................hpspphhthphpp-h-pRNRP.....LoDEELDplL..PsEGYcILcPPssYtPlRss....tpKlhtsssshts....ssFhl..-sspu..........tppl	................................................................................................................................ss...ts+.++SRWD.......p.TPt............sst..s.............................tssp++SRW..Dp..........TP..........s...uuTPss.st.....................shATPsssph................................hssppht.shpapp-I-cRNRP.....LoDEELDsMh..P...E..GYKlLtPPsGYsPIRTP....ARKLhATP.s..Phsu........sGFhhQ.pt-ps....tth.....................................	0	83	121	175
+8753	PF08921	DUF1904		Domain of unknown function (DUF1904)	Mistry J, Sammut SJ	anon	pdb_1u9d	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.10	21.10	21.20	21.50	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.28	0.72	-4.00	20	267	2012-10-01 20:38:22	2006-08-01 14:12:29	6	2	254	2	45	195	7	103.30	40	97.80	CHANGED	MPHlRhRGlspctVpplScsLlc-Luslsssss-sFTlEalsSshapsGphspsashVEVLWFsRsp-spctlAphIsctlpph..sptpcVsVhFpsLssssYYcNGpH	..................MPHl+FRulptphlpplSpsLlpELuplhpsspc..sFThEhhs..opahhsG......ch...t.sa.PhVEVhWFs.RsQchp.DplApsITph.l+p...su.sclsVlFhsLspsuYY.sGpH......	0	18	26	35
+8754	PF08922	DUF1905		Domain of unknown function (DUF1905)	Mistry J, Sammut SJ	anon	pdb_2d9r	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.00	21.00	21.00	21.10	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.60	0.72	-4.41	48	396	2009-01-15 18:05:59	2006-08-01 14:14:49	6	7	306	1	165	375	65	81.40	27	63.68	CHANGED	FsAplh...psss.....sasalslPh-sucplstt..............GplpVpuslsGpsaps.SlhP...spG......salLslctslR+stGh.ssGDpVplpl	..............Fpu.lh.....tsts......shsa.ltlPh-htcphs.t..............G.plpVpuslss.h.sacs.olhs...hGss.........salLslcpslRcthuh.psGDtVpVpl.........	0	76	135	155
+8755	PF08923	MAPKK1_Int		Mitogen-activated protein kinase kinase 1 interacting	Mistry J, Sammut SJ	anon	pdb_1vet	Domain	Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer [1].	20.50	20.50	20.50	21.00	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.17	0.71	-4.47	7	141	2012-10-02 21:07:43	2006-08-01 14:16:48	5	4	114	5	84	146	2	113.10	45	83.01	CHANGED	-cl+caL..thhppV-Gl...puIhloDRDGVslh+lup-ss.ss.shcPuhlsTFshAs-QusKLsLGcN+oIIshYpsaQlVQhN.....tLPLllohlusossNsGhILuL-ppltsll....p-lppsl	..................................................cl++aL..chL.pV.-G.L....auIlloDRDGVPll+..Vu..s-su..P-.hA.lRPuFLoT.Fu.hAoD.Q.uS....KL.GLuKN.KoIIshYss..YQ.V.V.QhN....................+LPLlloFIA.os....sA.NTGh....I.luLEccLsslh....c-Lcpsh.....................................................................	0	35	42	62
+8756	PF08924	DUF1906		Domain of unknown function (DUF1906)	Mistry J, Sammut SJ	anon	pdb_1sfs	Domain	This domain is found in a set of uncharacterised hypothetical bacterial proteins.	26.90	26.90	27.00	28.80	25.20	26.80	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.68	0.71	-4.30	35	469	2009-01-15 18:05:59	2006-08-01 14:22:11	6	19	346	1	122	422	5	132.00	30	30.10	CHANGED	tustl.s.spApsl+.suGassV.sRYlosspssst....hsKslotsElcslhsuGLplhslYQhs........shts.usastu.ttGst-ApsAhphAtthGhspsssIYFuVD..DssssphsshllPYF+uhpsslut....s.....YcsGlYG	.........................h....l....tsppl+..suGatss.sRYlosppssst............hsKslohsEhcsltssGLplhsl...YQhG.......................ttps..upas...t..u..sGhtcAp.pAhphtt.s.hGhP..s....ussIYhulD..Ds.sptphs...spllP...Yh+uhpsslst....p.........a+sGlYu.....	0	35	83	110
+8757	PF08925	DUF1907		Domain of Unknown Function (DUF1907)	Mistry J, Sammut SJ	anon	pdb_1xcr	Domain	The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase [1].	25.00	25.00	25.40	29.40	19.60	24.50	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.86	0.70	-5.32	14	174	2009-01-15 18:05:59	2006-08-01 14:24:16	6	5	109	2	102	187	329	237.30	46	85.41	CHANGED	VlpuuLppNFtsVpVoVspCPDLpcsPFphsspGLsGpspls-VGGssaLlPhsphsKhYslhslu+c.hch....ssth..llGAGAGPa.hlGpNsEhhhNlphp................psspssNtSahuplsstsspsllcKhsp..scschuLLuNLahsEG.KPGpVL+lpA+pRTGpc.sFlsCIRpuLcp+YG-..+sVuLGGsFll+pGKA+hHlMP.-F...SpsPlpocEcl.NpWL+aa-MsAPLlslsVllSpDP..GLDLRlEHhHsFS.pHGc..GGHYHaDT...TP-pVEYcGYFssAEtlYRl	......................VlptuLppNFtplpVs.Vs-CPDLsptPFphsspGls..Gpspls-VGGsPaLlPhsp..pcK.hYslppls+c.lph....sssh..llGAGAG..Pa.hhG.NsEhh.slphp................ttp..ssNuSahuplp..s.....ts.t.tsllc+h.sp....pchphuLLuNLahS-G.p.P.G..c.Vlc.lpA+pRpG.t....salsshRpsLpp+Yss..csluhGGhFllppGcs+.HlMs.-F..............SpsPlp...oc-cl..spWL+aa-hp.APLlshsshVop.........Ds...shDLRlpHhHs.FS.pcsp....GGHYHhDT......TP-tVEY.GYF.sA-hlhRl......................................	0	31	40	80
+8758	PF08926	DUF1908		Domain of unknown function (DUF1908)	Mistry J, Sammut SJ	anon	pdb_1v9v	Domain	This domain is found in a set of hypothetical/structural eukaryotic proteins.	25.00	25.00	27.70	27.70	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.89	0.70	-5.64	6	371	2009-01-15 18:05:59	2006-08-01 14:26:40	6	10	86	1	177	290	0	235.00	62	18.97	CHANGED	PlDSPRNhSsuuslsFPF..ARp.hsp..RADGRRWSlASLPSSGYGTNsPSSolSSSsSSQERL....HQLPaQPTsD-L+FLuKHFRSoE......................................................................SssDED..................G+hSPhhRPRSRSL.SPGRSssoFDNEIlMMNHVYKERFPKATAQMEERLp-hIschs..PssoLsLADGVLGFIHHQllELARDCLcKSpsuLlTSRYFhELQEKLE+LLpEA+ERS-SEEVshIspLl+KLLlIISRPARLLECLEFDPEEFY+LLEAAEGQAKVsQGIKTDIPRYIIpQLGLsRDPlEEl	....................................P.DSPRNhS.ss.ssh.pFsF...s...................Rs....DG..RRWSLASLP..S.SGYGT.....N.TP...S..ST..V....S..S..S.sSSQE+L..........HQL.P.a.Q..P....T.sDE......L......+FLoKHFtooE....................................................................................................................................................S...lssEp...................s.pp.us...hR.PR.SRSL..SPGRos.s......shDp..EIlMMNH..VYKERFPKATAQMEERLp.-hlps.s............PsssL...s.LAD..GlLuFlHHQllElARDCLsKS.cpsLITSpYFhELQ-pLE+L.Lp-Aa..-RS.-StElsaltpLV+KlLIlIuRPARLLE.CL.E..FDPEEFYa.LLEAA..EGHAKEG.p.G...............I....Ks....DIP.+YIIsQLGLs+DPLtEh..........................	0	34	49	103
+8760	PF08928	DUF1910		Domain of unknown function (DUF1910)	Mistry J, Sammut SJ	anon	pdb_2fef	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.90	21.90	22.00	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.62	0.71	-4.07	16	185	2009-01-15 18:05:59	2006-08-01 14:30:54	5	3	113	0	30	177	5	119.60	23	41.43	CHANGED	RDsLpsEphhhctIc.pcctltch...pEcIhphcpctcpslpRh.........tshhshahhshchllAcYShGpsl-phps.a.pslsthEc..................hh-tc.stYh.hLWhlSLuILLch-cp.plppLspll	.....................................RD.ltscphhpchlph.pctIpc....ppplhphc...psppps.htp..........thhhshht..hp...h.c.hlhspYShGpslpplpp.a.phlp..hhcp............................shptp..shY.hphlahlSLulLLchccc..hpcLhphl................................	0	7	18	27
+8761	PF08929	DUF1911		Domain of unknown function (DUF1911)	Mistry J, Sammut SJ	anon	pdb_2fef	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	30.30	27.20	22.00	18.70	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.51	0.72	-3.37	20	220	2009-01-15 18:05:59	2006-08-01 15:05:44	5	3	139	3	37	214	5	107.20	32	37.40	CHANGED	pcs...pDhLlchLlsstshs....p.spchhappPYttLhpsl.....spst-ppsctLtpYl.cpWY+uhcshsW+sp............H+tstt.....sYaGYWuFEuAAlshlhulDDSuh+Dpsa.YPtDL	..............................................p....pDhLl-hllth.tt.th...p.spp..hhh.pPYtthh.chl.....ppspppt.ctLppYl.cpWYcu.ppch..s..W..+ss..................HKps.......sYhGYWuFEsAAlsKlhsl.D..DosL+sps.a.YPhDL.............	0	8	23	32
+8762	PF08930	DUF1912		Domain of unknown function (DUF1912)	Mistry J, Sammut SJ	anon	pdb_1z0p	Domain	This domain has no known function. It is found in various Streptococcal proteins.	25.00	25.00	94.70	94.60	23.10	16.30	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-10.05	0.72	-3.89	17	344	2009-09-11 13:53:27	2006-08-01 15:07:31	5	2	343	1	24	96	0	83.70	81	98.41	CHANGED	MSYEQEFLKDFE-WVpoQIplNQhAMsoupKVhEEDtDERAtDAaIRYESKLDAYcFL.GKFsNY+NGKuFHDlPDGLFGpRHY	MSYEQEFMKEFEAWVNTQIMIN-MAhKESQKVY.EEDQDERAKDAMIRYESRLDAYQFLLGKFENFKAGKGFHDLP-GLFGERNY.	0	2	5	14
+8763	PF08931	DUF1913		Domain of unknown function (DUF1913)	Mistry J, Sammut SJ	anon	pdb_1zru	Domain	This domain has no known function. It is found in a various putative receptor proteins from Lactococcus bacteriophages.	25.00	25.00	25.10	28.30	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.74	0.71	-4.40	5	97	2009-01-15 18:05:59	2006-08-01 15:09:40	5	2	97	66	0	69	0	145.80	80	54.39	CHANGED	MTIKNFTFFSPNGTEFPVGSNNDAKLYMMLTGMDYsTIRRKDWpoPlNTALNVQYsNTSIIAGGRYFELlNETVALNANSVNYIHANIDLTQTTsPVSLSAETSDNSNsVDINNuSGVLKVlIDIlTTNGhGVostcsPsQsToLD	.......MTIKNFTFFSPNGTEFPVGSNNDGKLYMMLTGMDYGTIRRKDWoSPL.NTALNVQYsNTSIIAGGRYFELL.NETVALKuNSVNYIHANIDLTQTAsPVSLSAETus...NSNsVDlNNsSGVLKVshDIhTTsGTGVhSsKs.spsohLD..............	0	0	0	0
+8764	PF08932	DUF1914		Domain of unknown function (DUF1914)	Mistry J, Sammut SJ	anon	pdb_1zru	Domain	This domain has no known function. It is found in a various putative receptor proteins from Lactococcus bacteriophages.	20.70	20.70	21.60	21.70	20.60	18.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.59	0.71	-4.05	9	84	2012-10-01 20:11:45	2006-08-01 15:11:48	5	3	82	140	3	68	0	114.10	37	30.57	CHANGED	lssNsls...hpGSlsl.hp..sh....sGsGLphphpKKs.-lVlh+ahGpl...sshssGhphu..WVctPap..Pshsp.SLlG+F.........sspusSFHIDlsPsGohpWWGsshupssl..RGsu.YFI	..........................lssNslo...lpGSlsVPspp.Th...psGsGLpLpLpKKNsDlVIl+ahGsl...ss.lppGhshuh...sWVchPap..PsssQ.SLlGHh.........sGpsssFHIDlsPsGolsWWGsslusssh..RGsuoYFI........	0	2	2	2
+8765	PF08933	DUF1864		Domain of unknown function (DUF1864)	Mistry J, Sammut SJ	anon	pdb_1zee	Domain	This domain has no known function. It is found in various hypothetical and conserved domain proteins.	19.70	19.70	20.30	19.70	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.27	0.70	-5.94	11	77	2012-10-01 19:57:26	2006-08-01 15:13:56	6	1	76	12	22	87	28	363.90	45	96.75	CHANGED	TpsstAFDcWIRscFl-lNocLEpLYapQsD+AsVsGlG-sLKttLcsEG+shIpsLLsEGNTDEGFDuAFDLLGNVGLYMAACRRHEITEPSRETsSPLhEASALAMHIGASIGVsPRFATAHLTTHNpAhsGlYKRFTsLsDE+LFlDYNT+GILAYKRAADALL+I.PLGloHPhoA-LLcsAcpALpcVl-SNptLFppLDs-RFF.CVRPYYKPaRVGuplYRGANAGDFAGINVIDLlLGLCtAN-PuYSQhLVDKFLYMMPEDQslLRDCMRRsSLMDcFLsutctspp..sWaQ-Nl+LFLpVCchHGpTAIQHHsQLVpKaIApPucphpQpHhup....lTASGPPLcVLLsuLcKLRD+RAAA+.RsDIpTRapDIp...tLKuoL	.............................................hss.Ahs-.lpuR..tLs.pL.tL....sc+tsV....GIss.L+phL.scGhs..........os.GFspAhshhtslGhahuuh+RH..t.pEPsc....ssPhlEsshLsh..utuhGlsPR.shhHlTsaN....Atssh.+paTsLsDEthhl.-.sphuh.hAhctAhsAhl..clps....lulpp..Phhuphhcshttt...LpchlES.shhap.....plssphFa.t.plRPY...............Y.......cPhR.......VGup.........sYh..GssAs-hs.l.VlDhlLhhs..pAscsuYpphh.shh.YhhPp.ptlhtchhtcPuLhDchLttt.p.us.sp....hpEslph........G.sAlp+h.pllh+FhA..sp.h-p..ta.ut.......shuSGs.h.shLusL.pLp...RAAsp.RtcItst..................................................................................................	0	3	6	15
+8766	PF08934	Rb_C		Rb C-terminal domain	Mistry J, Sammut SJ	anon	pdb_2aze	Domain	The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure [1].	20.70	20.70	20.70	21.00	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.96	0.71	-4.59	6	127	2009-01-15 18:05:59	2006-08-01 15:15:48	5	4	54	18	50	123	0	125.00	55	15.18	CHANGED	ILQYASsRPPTLSPIPHIPRSPYKhPNSPLRVPGSNNlYISPLKS.oR.....hSPshMTPRSRILVSIGESFGou-KFQKINQMVsSSDRuhKRohDuSuAPKPLKRLRFDlDGQDEADGSKs.uGEStLIQKLAEMoSTRSRMQEQKMKE-s-occc.p	...................csPsLSPIPHIP.p.SPh.p.ss.SPhRIstt.sIYISPhKs..........sothTPRSplL.hphutS.......ScchpcINpMlps.u-.R.shKRuhp.s.u.ss.pPhK+Lp...................................................p....................	0	4	6	18
+8767	PF08935	VP4_2	DUF1865;	Viral protein VP4 subunit	Mistry J, Sammut SJ	anon	pdb_2bai	Domain	This domain is predominantly found in viral proteins from the family Picornaviridae. It is VP4 of the viral polyprotein which, in poliovirus, is part of the capsid that consists of 60 copies each of four proteins VP1, VP2, VP3, and VP4 arranged on an icosahedral lattice [1]. VP4 is on the inside and differs from the others in being small, myristoylated and having an extended structure. Productive infection involves the externalisation of the VP4, which is cleaved from the rest, along with the N-terminus of VP1. There thus seem to be three stages of the virus, ie a multi-step process for cell entry involving RNA translocation through a membrane channel formed by the externalised N termini of VP1 [2].	22.20	22.20	24.40	22.80	19.10	18.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-9.87	0.72	-3.38	12	688	2009-01-15 18:05:59	2006-08-01 15:18:15	5	18	80	15	0	699	0	81.60	66	4.62	CHANGED	GsGpSS.ssGspNpSGNoGsIINNaY.pQYQNShD..LusNshSstuspusssoosopoppotssshFSplus.........LLA	....GAGQSSPATGSQNQSGNTGSIINNYYMQQYQNSMDTQLGDNAISGG.......SNEGSTDTTSTHTsNT....QN......NDWFSKLAsSAFoGLFGALLA.....................	0	0	0	0
+8768	PF08936	CsoSCA		Carboxysome Shell Carbonic Anhydrase	Mistry J, Sammut SJ	anon	pdb_2fgy	Domain	Carboxysome Shell Carbonic Anhydrase is a bacterial carbonic anhydrase localised in the carboxysome, where it converts bicarbonate ions to carbon dioxide for use in carbon fixation. It contains three domains, these being: (1) an N-terminal domain composed primarily of four alpha-helices; (2) a catalytic domain containing a tightly bound zinc ion and (3) a C-terminal domain with weak structural similarity to the catalytic domain [1].	20.60	20.60	21.20	20.90	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	459	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.51	0.70	-6.13	22	80	2009-01-15 18:05:59	2006-08-01 15:21:33	5	1	77	2	31	84	273	428.30	46	83.35	CHANGED	HPLocpstNpcLpsYEppVKu+F-cIVPlLKclSulQH-.DFlppAQpLA+tcLGFsLPpplL-cAWVpsLDMRu......LaAaCVFpoapphS-pFFpsDPLpu....ppupth-sFLh-CGFHhlDlo.PCADGRLAHsluYsLRl.PauuVR.R+uHAGAhFDlEsoVs+Wl+TEHpRaREuhPNsAcpsTRYLKlslYHFSShDPsHpGCAAHGSsDthAApAuLpRLh-FRpAlENoFCCGASVDlLLIGlDTDTDAIRVHlPsssGclsLccalsstplYppThsLou-pA+tpItpsl........pstusus.p.GMhphIspLltNNlSQIDYVpphHsGpYs..DhGHAERFIGVG.GF+EVpLRNLoYFAHLDTVEEGAPDLDVGlKIFpGLNVu+sLPIPVllRFDYsu+VPGAR-RAlscCpRVpsAIpsRYs-LsspGLLashlTlR..DRsttssuEsVuushD	...................................................................HPLospttNppLhsYEpplKucF-pIVPsL+cluulQH-.DFhppAQplu+tcLGacLPpplL-cAWVpsLDMRA......LaAaClFpoachhu-pFapssPLpt....tpupthcpFLl-CGaHhlDlo.PCuDGRLutslsYsLRl.Phu.uVR.R+uaAGAhFDlEssVp+WscTEhcRaREuhPNsAptsTRYLKllsYHFSSsDPpHpGCAAHGSsDchAApAuhpRLh.cFRpAVENoFCCG.A.SVDlLLIGlDTDTDAIRVHlPsscG.chsLc+alsstpLYppThshss-pActpltpsl.........tutusus.p.GMhphlspLltNNlSQIDYVpphHsGtYs..DhGHAERFIGVG.GFcEVpLRNLsYFAHLDTVEEGAsDLDVGl.K.IFpuLNVu+sLPIPVll+F-Ysu+VPGuRERAltcCpRVpsAIpsRYscLsppGLLpstholR..D+stssshEhlut.........................	0	8	19	28
+8769	PF08937	DUF1863		MTH538 TIR-like domain (DUF1863)	Mistry J, Sammut SJ	anon	pdb_1eiw	Domain	This domain adopts the flavodoxin fold, that is, five parallel beta-strands and four helical segments. The structure is a three-layer sandwich with alpha-1 and alpha-4 on one side of the beta-sheet, and alpha-2 and alpha-3 on the other side. Probable role in signal transduction as a phosphorylation-independent conformational switch protein [1]. This domain is similar to  the TIR domain.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.55	0.71	-4.10	55	389	2012-10-02 18:56:14	2006-08-01 15:25:41	6	7	328	1	118	650	62	126.70	18	55.87	CHANGED	++lFlSacapsDs...php........pl+shhstp....tp.....t.hshs.hc.h.....pppscs....tI+chI.ccplpsossslVLlGppT.tp.........pcWVcaEIp.........................................................tuhc.........pspsllulplpshp..s............ssshsssshsh	...................................................hcsFlSapapcst........hhp..........tltphh..tp...................t..php...phc.h.....pppspt.....tlcphl.ccplpsossslVL.lGtpT.tp...........................ppW.l..pa..E.....I..p......................................................................................................................................................................t..uhc.....................tspsllulhlps....pph........................hh...............................................................................................................................................................................	0	36	74	99
+8770	PF08938	HBS1_N	DUF1916;	HBS1 N-terminus	Mistry J, Sammut SJ, Eberhardt R	anon	pdb_1ufz	Domain	This domain is found at the N-terminus of HBS1 proteins. It interacts with the ribosomal protein rpS3 at the mRNA entry site [1].	23.00	23.00	23.50	23.50	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.55	0.72	-3.86	47	250	2009-01-15 18:05:59	2006-08-01 15:33:01	5	9	187	2	144	233	1	100.30	25	15.27	CHANGED	D.-Dh..................................................psEs-....................tpcpLssE-pct.hppshspl+ptLsstss.h..s-pplp-ALWaaYaDl-KulshLhpchpsptsppp	............................................................................p...-h...................................................-.-sp.............................tps.tpcpLss..Dpsp.L.sslschRplLG-ss.....s-pplhEAlh+.......htFDlpKulshllpppptps.t..t..................	1	35	63	107
+8771	PF08939	DUF1917		Domain of unknown function (DUF1917)	Mistry J, Sammut SJ	anon	pdb_1ztp	Domain	This domain is found in various hypothetical and basophilic leukaemia proteins. It has no known function.	20.40	20.40	20.40	20.70	19.70	20.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.76	0.70	-4.63	20	148	2009-09-11 14:20:58	2006-08-01 15:35:33	5	5	120	6	107	159	2	202.60	27	72.09	CHANGED	phcphspsasstsaatptcsph.thh.....pst..............................t-tcspplhpstpos...................sEssssFLsRlsPuss.........Ia..........................t....chsptGpphLpthpphtthlptppsp.....t...uhsRtlsstRpth.pplhpLAhpstlhoGKWhlFlss-.cVDcsWptVAcATl.pGcLGhuAKVuT.......tscspspsRLIsVYTc......DasDcsDVhRVlc+LccL.Gllc.tt...IhYKsDsa..TYLs	............................................................................................................t................................................................................t...........ts........................................................tttlstaLt+h.Psps...........................................................s......thhp.up...p.ht.hh.hhtt...t................tshpt...spt....+....h.tplhpLAhppplhoGKWhla.hsss...clD.csWstlAcAss..pGc.....L..........s....A....KVus..................psptstpplICVYTp......DFpDct-Vh+lhp.tl.+ph...Glhp...............lhYKsDsaTah..................................................	0	33	62	83
+8772	PF08940	DUF1918		Domain of unknown function (DUF1918)	Mistry J, Sammut SJ	anon	pdb_2a7y	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	20.80	20.80	21.10	26.40	20.70	18.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.81	0.72	-4.63	18	199	2009-01-15 18:05:59	2006-08-01 15:37:26	6	7	132	1	67	133	1	57.00	55	62.72	CHANGED	M+ApsGDpLlV+Gpslsps-RcGEIlEV+G-cGuPPYlVRWpDpGHpohVaPG..PDAhV	...M+AcVGDhLVl+GsTlsptD+cGEIlEVRu.sDGuPPYlVRW...-sGH-uhVaPG..PDAlV...............	0	23	55	66
+8773	PF08941	USP8_interact		USP8 interacting	Mistry J, Sammut SJ	anon	pdb_2fzp	Domain	This domain interacts with the UBP deubiquitinating enzyme USP8.	25.00	25.00	29.50	32.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.27	0.71	-4.95	5	110	2009-01-15 18:05:59	2006-08-01 15:38:36	5	7	71	6	69	97	0	166.80	59	55.14	CHANGED	ELRolVQsQsp+lAELKpppsDpcpQluEQKRElpLlKtYlRAlRSoN..........PthRNlu-QlE+s..ElhcWssGLssARVTRWGGMISTPDssLQhlIRRuLsESGCPsHILN-LlENCHERRWPpGLuTLETRQtNRRhYEpYVsRRIP....GKQAVVVhuCENpHMuEslps-PGLVMIFAHGVE	................................cLRolVQpQQs+IuELccptuEpcpQluE.QKR-lQLLKsYMRAl.RSsN..........................PslpNlt-plEhs..EllcWssoLt.ARVTRWGGMISTPDslLQ..thIKRuLsESGCPspIls-LhENsHERpWPpGLuTLETRQhNRRhY-NYVs+RIP....GK......QAVVVhuC-NpHMs-Dhh.EPGLVM...IFAHGVE............................	0	17	21	43
+8774	PF08942	DUF1919		Domain of unknown function (DUF1919)	Mistry J, Sammut SJ	anon	pdb_2g6t	Domain	This domain has no known function. It is found in various hypothetical and putative bacterial proteins.	25.00	25.00	25.80	25.70	21.10	19.90	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.40	0.71	-4.96	15	177	2009-01-15 18:05:59	2006-08-01 15:41:26	5	2	148	2	17	139	4	178.80	38	78.08	CHANGED	l....+p.........hh++lh+phhspph+p+LpNp...shTIISsNChGuhIhccLuhpFpSPFlNLalpssDYlKhLcNhcaYhpp-..LsFhpsscs..............tYPlGpL....sDIcl+FhHYpS.cEA+sKWpcRpcRINaDNLalhhsD+Duso.c.lpcFDpLPaKNKVlFosK....sYsplcSshaI.uhEsps....pVushh...tth.s+cYhcpFDhlsWlN	...............................hhpph.t..hshh.hhcLpsp...sholISsNChGuhlh+pLs..apoPFVs.Lal.s.pDal+hLpNhcaY.hppp..LsFhpppps.................YPlGh.L......sDlcIHFhHYpS.pEAppKWpcRppR.l.......Nh......cNLahhhs.-cD...u...s...o.c.lpcFDpLPapNKllFsp+....sY..thc..S..thhlpu..Epps....plu.hh.........pp.hhp.FDhhsWhp................................................	0	6	11	15
+8775	PF08943	CsiD		CsiD	Mistry J, Sammut SJ	anon	pdb_1jr7	Domain	This family consists of various bacterial proteins pertaining to the non-haem Fe(II)-dependent oxygenase family. Exact function is unknown, but a putative role includes involvement in the control of utilisation of gamma-aminobutyric acid [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-12.02	0.70	-5.52	11	476	2012-10-10 13:59:34	2006-08-01 15:43:17	5	1	456	2	26	252	906	284.50	85	90.83	CHANGED	GaolssaspssRLhplTlscpsLcsFl-pspcasVQALEYKPFhRFclAchLcclsussLtshLssIlpDRcpGuFllsspGlss........ps--hVKhuTAluHLIG.sNaDAMoGpYYARFsVKssDNSDSYLRQAaRlM-LHsDGTaVcEtTDalLMMKhDEpNhtGG-ShLLHLDDWpDL-+FasHPLA+pshhasuPsSKNVsccVpHPVFFt.DspG+PsMpFIDQFspPpNh-EGhaLp-LS-SlEsSpsshsVplPlGshlVlNNaFWLHGRctFpts.sLpRELMRQRGtFs	..............................................................................GFTLhPSAQSPRLLELTFTEQTT+QFLEQVAEWPVQALEYKSFLRFRVGKILDDLCANQLQPLLLKTLLNRAEGALLINAVGIDDVA......QADEMVKLATAVAHLIGRSNFDAMSGQYYARFVVKNVDNSDSYLRQP......HRVMELHNDGTYVEEITDYVLMMKIDEQNMQGGNSL.........LLHLDD.W.E.H.L.Dc.aFRHPLARRPMRFA....A.PP....S.....K..N.V...SK.D.VFH...PV..FDVDQQ.G.R.PVM.RY....I....DQF.VQ........PK...DFEEGV.W..LS..ELSD...AI..E.......TSK..GI.......L.SV.......P.....VPVGKFLLINNLFWLHGRDRFT.P..HP.D...LRRELMRQRGYFA..............	1	5	8	18
+8776	PF08944	p47_phox_C		NADPH oxidase subunit p47Phox, C terminal domain	Mistry J, Sammut SJ	anon	pdb_1k4u	Domain	The C terminal domain of the phagocyte NADPH oxidase subunit p47Phox contains conserved PxxP motifs that allow binding to SH3 domains, with subsequent activation of the NADPH oxidase, and generation of superoxide, which plays a crucial role in host defense against microbial infection [1].	21.50	21.50	22.30	22.40	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.94	0.72	-3.78	12	85	2009-01-15 18:05:59	2006-08-01 15:48:52	6	11	38	2	33	74	0	58.90	39	14.82	CHANGED	.LQpR+pt.cshPpusuos......spsppsKstPslPPRPSs-LILcRCoEsT++Klo..pus	............................................hppR+p..tshsppssss....................spspcsKspPsVPPRPSs-LILpRCoEsT++Kls.....s.......	0	4	9	18
+8777	PF08945	Bclx_interact		Bcl-x interacting, BH3 domain	Mistry J, Sammut SJ	anon	pdb_1pq1	Domain	This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11 [1]. This domain is also known as the BH3 domain between residues 146 and 161.	25.00	25.00	62.30	62.20	21.80	20.60	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.05	0.72	-4.42	6	51	2009-09-10 23:22:43	2006-08-01 15:49:49	5	2	33	14	21	67	0	38.60	75	22.36	CHANGED	huup+ppputPsc.lpPElWIAQELRRIGDEFNu.a..P.RRu	......MAShRQSQAEPAD.MRPEIWIAQELRRIGDEFNA.Y.Ys.RR....	0	2	3	6
+8778	PF08946	Osmo_CC		Osmosensory transporter coiled coil	Mistry J, Sammut SJ	anon	pdb_1r48	Domain	The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function [1].	23.80	23.80	23.90	24.40	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.31	0.72	-3.93	10	544	2009-01-15 18:05:59	2006-08-01 15:51:13	5	3	540	2	42	183	0	46.10	82	9.30	CHANGED	SDlpEAKElLpEHHDNIEQKIEDIDpQIAELpcKRp+LlcQHP+Is	.....SDIQEAKEILsEHYDNIEQKIDDI.......D.......cEI.......A-....LQ.......A.......K.......RoRLVQQHPRID....	0	5	11	25
+8779	PF08947	BPS		BPS (Between PH and SH2) 	Mistry J, Sammut SJ	anon	pdb_2auh	Domain	The BPS (Between PH and SH2) domain, comprised of 2 beta strands and a C-terminal helix, is an approximately 45 residue region found in the adaptor proteins Grb7/10/14 that mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor [1].	19.10	19.10	19.20	25.40	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.42	0.72	-4.34	4	191	2009-01-15 18:05:59	2006-08-01 15:55:43	5	6	54	1	97	163	0	47.70	66	9.83	CHANGED	RSsSENSLVAMDFSGct.GRVI-NPsEA.SsAlEEGpAWRK+oshRhuhh	............RSlSENSLVAMDFSGpt.GRVIENPsEA.SsAlEEG....pAW.R..K+us.Rhsh..........	0	11	18	45
+8780	PF08948	DUF1859		Domain of unknown function (DUF1859)	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	This domain has no known function. It is predominantly found in the N-terminus of bacteriophage spike proteins [1].	25.00	25.00	32.00	205.40	21.70	20.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.68	0.71	-4.39	2	14	2009-01-15 18:05:59	2006-08-03 15:07:56	5	2	6	1	0	7	0	123.50	66	53.00	CHANGED	Msspp.st.TVT..YNGs.shtGP.ulpuhh-.lAGppVhhDLph.hsTtthoGVQslYID.t-..Gshplsh.-TGQRIps.AGpQGYaPlLssshhKFlspthhsGK..hPh.FlNFsIA.GVW	Msspp.st.TVT..YNGs.shtGP.ulpuhh-.lAGppVhhDLph.hsTtthoGVQslYID.t-..Gshplsh.-TGQRIps.AGpQGYaPlLssshhKFlspthhsGK..hPh.FlNFsIA.GVW	0	0	0	0
+8781	PF08949	DUF1860		Domain of unknown function (DUF1860)	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	This domain has no known function. It is predominantly found in the C-terminus of bacteriophage spike proteins [1].	25.00	25.00	462.10	461.40	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.65	0.70	-4.74	2	7	2009-01-15 18:05:59	2006-08-03 15:09:31	5	1	6	6	0	7	0	219.00	96	64.41	CHANGED	PSGIKGDKGDPGtPGPAGGTVVVEDSGA.FGESLLDTsS-PGKILVKRISuGSGITlTDYGDclEIEAo.GGGGGGGGVTDALSLhYoTSoGGPASIAANALTDFDLSGALplNpVGTGhTKuAsGIQLAAGKSGLYQlTMTVKNNTVTTGNYLLRVKYGSs-aVsACPASoLTAGGTISLLIYCpVLGVPSLDVLKFSLCNDGAALSNYIINITAAKIN	PSGIKGDKGDPGtPGPAGGTVVVEDSGA.FGESLLDTTSEPGKILVKRISuGSGITVTDYGDEVEIEAS.GGGGGGGGVTDALSLMYSTSTGGPASIAANALTDFDLSGALTVNoVGTGLTKSAAGIQLAAGKSGLYQITMTVKNNTVTTGNYLLRVKYGSSDFVVACPASSLTAGGTISLLIYCsVLGVPSLDVLKFSLCNDGAALSNYIINITAAKIN	0	0	0	0
+8782	PF08950	DUF1861		Protein of unknown function (DUF1861)	Mistry J, Sammut SJ	anon	pdb_2b4w	Domain	This hypothetical protein, found in bacteria and in the eukaryote Leishmania, has no known function.	18.70	18.70	102.30	102.20	17.30	16.20	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.91	0.70	-5.61	12	151	2009-01-15 18:05:59	2006-08-03 15:10:58	5	1	107	1	25	116	5	292.00	48	95.12	CHANGED	htsFcts..cpha-sshLoFpGVsshDVYNhSsPFphpGchaIhGRVEcRDp.tpScVhhFpEstcspassV.sshsapLpDPFlo+lpsEhlFGGsclh....sssphhsahssFYRGp.hppLpaFsoGP-tMKDIRlVcLtDG+IGVFoRPpsc..ucshIGFshlssLsELTs-sIspA.hlc.thps-tWGGVNpsaLLosGplGsluHhuhh.Dpcsscc....YhshSFVhsPcTpphpph+lIuT+usFsssssKtPcLtDssFuuGllh+sDG+s-LYuGlGDsctt+lsI-.PFcGa	...........h...acpp..ppsapst+LpFsGV.s-+DVYNIoAPFp.tGphhIAGRVEuRDS.EtScVhFFpcp.pspas.VEssssat.LQDPFloplpGELIhGGVElhP+..sssshLsW+TsFYRGpslpsLppFhsGPsGMKDIRlscLtDG+IGVFTRPQG-h.....GGRGpIGashIsoL--LT.EsIpsA.LLcppFss-EWGGsNEsHLLssGpIGlLGHIAsFDppGsRH....YYshsFhhNs-opphpphKIIApRusFhPussKRPDLsDVlFoGGLlhpsDGsscLYuGluDu-Ap+IsIsDPFps......	2	12	20	22
+8783	PF08951	EntA_Immun		Enterocin A Immunity	Mistry J, Sammut SJ, Coggill P	anon	pdb_2bl8	Family	Gram-positive lactobacilli produce bacteriocins to kill closely-related competitor species [1]. To protect themselves from the bacteriocidal activity of this molecule they co-express an immunity protein (for discussion of this operon see Bacteriocin_IIc Pfam:PF10439). The immunity protein structure is a soluble, cytoplasmic, antiparallel four alpha-helical globular bundle with a fifth, more flexible and more divergent C-terminal helical hair-pin [2]. The C-terminal hair-pin recognises the C-terminus of the producer bacteriocin and this interaction is sufficient to dis-orient the bacteriocin within the membrane and close up the permeabilising pore that on its own the bacteriocin creates [3]. These immunity proteins interact in the same way with other bacteriocins, family Bacteriocin_II, Pfam:PF01721. Since many enterococci can produce more than one bacteriocin it seems likely that the whole operon can be carried on transferable plasmids [4].	21.40	21.40	21.40	21.50	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.20	0.72	-3.83	62	1139	2009-01-15 18:05:59	2006-08-03 15:14:23	5	3	516	8	131	559	0	73.70	19	66.60	CHANGED	pcppph...hpplhpll...p..s.ptpp.plcplLhpstpclcpsps...h.hlhs+Lspslpthsh.p...phpLsps.pphhppl	............................pph...hphl.ppLh....pphchs.tsp..clpphLhpstpcLcpspp....phlhscLsptls.hhhhp...phphstplhshhh.l.....................	0	24	44	81
+8784	PF08952	DUF1866		Domain of unknown function (DUF1866) 	Mistry J, Sammut SJ	anon	pdb_1ufw	Domain	This domain, found in Synaptojanin, has no known function.	20.40	20.40	20.50	20.50	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.76	0.71	-4.66	6	189	2012-10-02 20:46:34	2006-08-03 15:35:34	6	6	73	2	80	187	1	141.10	47	10.92	CHANGED	Dl-lhEVDsppRpsVac-VIuspGPPDuTllVslpS.........s.sEsshFD-sLhspLlppLupaGEVsLVRFVp-pMWVTFtDGpSALssLslsuhpVhG+slpI+LKS.-Wl+tLE-El..psssplshu...ossSsLLu-ssshsss-a	............................-l-l.EV-sptRppVapEVhuhQGP.DuTVlVslpS...............oh.Eps.F.s-sLhsELhQphus.aG.p.ll.Ll.R.h.....sp.s...pM.....hVTFh-upSALsVLs.lsG..hcl.hGR.slpIp.Ko.D..Wl...KsLcEEh...p.phhslu...ossSsLLtEsh-hst......................................................	1	18	25	47
+8785	PF08953	DUF1899		Domain of unknown function (DUF1899)	Mistry J, Sammut SJ	anon	pdb_2akf	Domain	This set of domains is found in various eukaryotic proteins. Function is unknown.	20.70	20.70	20.70	20.80	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.05	0.72	-4.33	33	702	2009-01-15 18:05:59	2006-08-03 15:39:09	6	34	265	2	401	638	1	64.30	49	12.32	CHANGED	+hVRsSKaR...HVFGpssK+EpCY-sl+locssWDoshsulNPKalAVsh-uuGGGuFhVlPlsc.sG	.........phVRsSKFR............HVFGp.ss.Kp...-pCY-sl.+.l..S+s.s..W.D.o.sFCA..............VNP+FlAllhEuuGG.G..AFhVlPLpcoG........	0	119	174	282
+8786	PF08954	DUF1900		Domain of unknown function (DUF1900)	Mistry J, Sammut SJ	anon	pdb_2akf	Domain	This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It has no known function [1].	21.20	21.20	21.20	21.60	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.62	0.71	-4.64	64	952	2012-10-05 17:30:43	2006-08-03 15:41:35	6	51	276	2	567	880	1	128.00	42	25.62	CHANGED	Plss.hslDsusGlLhPaYDpDosllYLsGKGDusIRYaEl..ss-...t.hlphlspapSssPp+.........................Ghu.hhPKpulDVpcsElsRhh+lsss..s......lcPlSahVPR+.u.-hFQcDlYPsohus.cPuloAc-Wh.sGpssp..PhhlSl	......................lt..plDs.Ss.GlLhPaYDsDosllYLsGK......G..DusIRYaEl.........ss-..........tPalph.Lsp.a..p.S...t.c.PQ+.........................G.hu.hhP..KRu..l-VpcsE.ls.RhaKLpppp......lEPIuhhVPR+.........u....-hFQ-Dl.....YPsTsus.cP.u.ls.AcEWhsGpstt..PhhlSL.....................	0	177	252	404
+8787	PF08955	BofC_C	DUF1901;	BofC C-terminal domain	Mistry J, Sammut SJ, Bateman A	anon	pdb_2bw2	Domain	The C-terminal domain of the bacterial protein 'bypass of forespore C' contains a three-stranded beta-sheet and three alpha-helices. Its exact function is, as yet, unknown [1].	20.60	20.60	20.60	25.20	19.80	20.00	hmmbuild  --amino -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.37	0.72	-3.93	10	152	2009-01-15 18:05:59	2006-08-03 15:43:03	5	2	152	1	28	109	0	75.70	57	41.96	CHANGED	DDISPLsKsNGYhGlo-DGllSlFcG+Pcps.chIQSFFQIDlp+LES+hpcpLc+GIPl+TKpcaccVIEth+sY	..........DDISPLLKssGYFGVS--GlLpIF+GsP...cs-..psI+SFFQIDh+K....LE....Sa....c....+....s+LK+GIRI+SKEtFscsIE+hKpY....	0	9	18	20
+8788	PF08956	DUF1869		Domain of unknown function (DUF1869)	Mistry J, Sammut SJ	anon	pdb_1nei	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.30	21.30	21.50	21.30	20.20	20.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.87	0.72	-4.37	3	423	2009-01-15 18:05:59	2006-08-03 15:45:07	5	4	421	2	17	63	0	58.90	87	91.84	CHANGED	pscGpFLLTVTNNNNGVSVDK-FSoLAsL+DPplAAEoVKDLVNIVRGYDoDEETNVCGW	......MGKATYTVTVTNNSNGVSVDYETETPMTLLVPEVAAEVIKDLVNTVRSYDTENEHDVCGW.........	0	1	5	11
+8790	PF08958	DUF1871		Domain of unknown function (DUF1871)	Mistry J, Sammut SJ	anon	pdb_1u84	Domain	This set of hypothetical proteins is produced by prokaryotes pertaining to the Bacillus genus.	19.60	19.60	20.80	19.70	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.61	0.72	-3.91	7	175	2009-09-11 15:05:30	2006-08-03 15:49:52	5	2	170	1	22	97	0	78.70	47	89.54	CHANGED	ptMlclltpWDPFphGc-aY-TEsuDVlpAlash-DPcpLA+pIQpIYEhSFEphlPlEsCp+lAtpLLhIKpuuSCoh	......pMlcllcsWDP...Fp.....h....G....s......-....FYETEAuDVVsllpshD..Dsc..h..lAKcIQ+IYhhSFE..E...s....s..l..EcC.E..K..lAhcLLsIK-uuSCo.L....................	1	5	12	16
+8792	PF08960	DUF1874		Domain of unknown function (DUF1874)	Mistry J, Sammut SJ	anon	pdb_2blk	Domain	This domain is found in a set of hypothetical viral and bacterial proteins.	20.30	20.30	22.00	21.30	19.50	19.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.12	0.72	-4.29	12	35	2009-09-12 20:42:06	2006-08-03 15:52:21	5	3	35	6	11	38	1	104.10	29	78.08	CHANGED	Mt......lalhNuhhhsh..stpshhphccIshpEsKphl....psppFlSAIGHcuTAplloplhsssl.hNRlplphp.GD+AlshhLppRl.EGpVL.opcElc......cIuaphhlh	...................lYllNuhslsh...sp....shhchcclsh.cEscphl.....pspphlSA.IGHcuTApllspLL.s.........ssl.h..NR..lplchptGDcslshp.LppRl.EGpll.stcElp......clta.hh..h...................	0	7	9	9
+8793	PF08961	DUF1875		Domain of unknown function (DUF1875)	Mistry J, Sammut SJ	anon	pdb_2crb	Domain	The MIT domain, found in Nuclear receptor-binding factor 2, has no known function.	25.60	25.60	25.70	25.70	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.69	0.70	-5.06	3	73	2009-01-15 18:05:59	2006-08-03 15:53:06	5	3	39	1	40	59	0	206.80	62	81.58	CHANGED	MKLTESEQAHLSLELQRDSHMKQLLLIQERWKRAKREERLKAQQuTE+DAAsHLQssH+PSsEDAEGQSP.LSQ.Y.PSTE+pLPElQGlFDRDPDTLLYLLQQKuEPuEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGshEKELDVDADFVEpSELWuLPsHuEoAsASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPL.....MELSEDILKGFMND	....................MKLTQSEQA+LSLELQRDSHMKQLLLIQERWKRApREERLKAQ...Qs...sD+-ssspLQsSt+PuuEDu-ups...P.l...s...pcaSPSsE+pLsElpGlFDRDPDTLLaLLQpKp.....E.....PsE.....PC.IGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLR+ENKQLKAEKARLlKGPhEKELDVDADFVEpSELWuLPP+S-oAsu.S..uoWQKFA.usoGKA.KDIPIPNLPPLDFPSPE......LPL.....hELSEDILKGhMs.................................................	0	2	5	20
+8794	PF08962	DUF1876		Domain of unknown function (DUF1876)	Mistry J, Sammut SJ	anon	pdb_2fgg	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	38.90	38.50	23.90	22.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.73	0.72	-4.20	6	190	2009-01-15 18:05:59	2006-08-03 15:54:17	6	2	118	1	53	125	0	86.30	47	88.10	CHANGED	HVhpsWpVDlpI-EHDp+TRAKARLR.WcG+ElVGVGLARLcPADcsVPcIGDELAlARALSDLApQLLsloocDIEAuTHQPu+sLa	.......hppWpl-l..I.-E+.....-.....t.....p.TRA+ARLc..h.....ss..p....pls..GsGlARhsPuDpsVPcIGDELAlARALuDLAppLlphuspDIEA..s.THpPsphl...........	0	16	44	50
+8795	PF08963	DUF1878		Protein of unknown function (DUF1878)	Mistry J, Sammut SJ	anon	pdb_1sed	Family	This domain is found in a set of hypothetical bacterial proteins.	20.90	20.90	20.90	22.50	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.50	0.71	-3.86	5	133	2009-01-15 18:05:59	2006-08-03 15:55:35	5	1	128	3	17	68	0	110.50	60	97.71	CHANGED	MpSlEcRlu+LEYYlcLLlcslDM-KYPFYuLlI+KsLoKEEu-Elt+lCcELu-EhEsQKAQGaVhFDcLLsLFAGQLsEKL-VHETIFALacQGLFpPLMsEFIoII+paD	...M.DVV+RLEQAEYYV-LLFKMI...DEEK..CPFYSLIIKKKARKKDIERILsLCEpLNEQYlsEKAEGLLLFDALLDQFEKALPHQLEVHETAEALtKQGLFpPLMNEFLsMIA+..c.....................................	0	1	7	10
+8796	PF08964	Crystall_3	DUF1881;	Beta/Gamma crystallin	Mistry J, Sammut SJ, Eberhardt R	anon	pdb_1yhp	Family	This family of beta/gamma crystallins includes the N-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 (Swiss:P54657), which mediates cell-cell adhesion through homophilic interactions [1].	26.70	26.70	26.70	27.00	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.86	0.72	-4.26	17	98	2012-10-01 23:14:22	2006-08-03 15:57:29	5	9	60	8	21	97	3	87.90	34	21.43	CHANGED	.sstshFappKNapGpuapYspussl....h.h.sspLND+FhSVclGstscVhhWcH.......pstshhhchssspsDlop.lsGLS+FpVhs	................tVCFYt-cNasG-SlChspGppl...........tsh.ssphND+lpSIpIPtuhpVTlYEcs....satGt.hshptshs...l.......................hs.p.s.h.....................	0	7	16	18
+8797	PF08965	DUF1870		Domain of unknown function (DUF1870)	Mistry J, Sammut SJ, Bateman A	anon	pdb_1s4k	Domain	This domain is found in a set of hypothetical bacterial proteins. It contains a helix-turn-helix domain so may be a DNA-binding protein.	23.60	23.60	24.10	24.40	22.90	23.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.66	0.71	-4.44	4	448	2012-10-04 14:01:12	2006-08-03 15:59:13	5	2	411	2	9	103	0	104.80	77	97.79	CHANGED	MNshELQALR+IhhhsIsEsAphIupsssSpTWQpWEsGclsIPs-l.tclhphpphRp+hlstllccls.......NtlGp.ThRaasDLpuFpphYs-usalcW+lYQSVsucLaAcsh-.cLs	......MNAYELQALRHIFAMTIDECATWIAQTG......sSESWRQWENG+CAIPDpVVEQLLAMRQQRK++lpAIl-KIN.......NRI..G...NNT.MRFFPDLTAFQpVYPDGNFIDWKIYQSVAAELYAHDLE.RLC........................................	0	2	4	6
+8798	PF08966	DUF1882		Domain of unknown function (DUF1882)	Mistry J, Sammut SJ	anon	pdb_2atz	Domain	This domain is found in a set of hypothetical bacterial proteins.	20.50	20.50	21.80	54.40	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.46	0.72	-4.01	10	188	2009-09-11 17:04:33	2006-08-03 16:02:25	6	1	188	1	17	76	0	72.60	66	40.34	CHANGED	MoshDLsLIKh.TsHYYIKRDsIlsKIca+GRpFasKFERIDAPLohsllpcHhc+cIslAHSLIs.+sDKVEN	.........hosMDhSLIKIIoDHYYI+RDpIspKITH+GRlFFDKFERVDAPLNhNlM+EHssKKIlVAHDLIo.KDNKVEN.....	0	5	14	17
+8799	PF08967	DUF1884		Domain of unknown function (DUF1884)	Mistry J, Sammut SJ	anon	pdb_1she	Domain	This domain is found in a set of hypothetical bacterial proteins. It shows similarity to the N-terminus of ATP-synthase.	28.60	28.60	28.80	72.50	27.90	28.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.75	0.72	-3.92	7	26	2009-01-15 18:05:59	2006-08-03 16:05:13	5	1	14	1	21	30	0	87.80	46	89.25	CHANGED	Mss..ps.hlcIls.lEptIsELK.-Ga-PDlILsG.Ehhcahsc..........shhph.pl+VhhlEELGsDAllsDSKhLG.l.tAuKRIpI.P	.........ps.hlclLshlEcphNELKh-GaEPDllLsG.Ehhcalsp..........chhchssLKlhll-ELGsDAVlsDSKhLG.lhtAuKRIpI....	0	2	2	11
+8800	PF08968	DUF1885		Domain of unknown function (DUF1885)	Mistry J, Sammut SJ	anon	pdb_1t6a	Domain	This domain is found in a set of hypothetical proteins produced by bacteria of the Bacillus genus.	25.00	25.00	29.60	118.30	20.60	19.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.66	0.71	-4.47	4	111	2009-09-11 06:05:25	2006-08-03 16:06:35	5	1	111	1	11	61	0	131.20	70	99.20	CHANGED	M.ppAaIKLV.pSsppoloI-DVKcLhchYKslTuKTG-QlsaAYspsAFPYEIh-pot...osLhLQSsc-RYssIhlGVs.........oEp-QoFIQloLPssATaGDKGKANEFs+FLAKKLpGELQLFNGRTMYFhpR	....MQHAFITLVPKSN.QQSVSIDDIKQLFHYYKTVTSKTGsQINYuYTNTAFPY-ILDTSs......TTLKLQSoH.DRYDSIYlGVG..........I.Ep....E...QS.....aIQlSLPPNATFGDKGKANEFCRFLAKKLEGELQLFNGRTMYFYKR.	0	3	6	7
+8801	PF08969	USP8_dimer	DUF1873;	USP8 dimerisation domain	Mistry J, Sammut SJ, Bateman A	anon	pdb_2a9u	Domain	This domain is predominantly found in the amino terminal region of Ubiquitin carboxyl-terminal hydrolase 8 (USP8). It forms a five helical bundle that dimerises [1].	20.90	20.90	20.90	21.00	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.35	0.71	-4.13	25	410	2009-01-15 18:05:59	2006-08-03 16:08:08	6	16	194	4	269	390	3	106.40	26	18.47	CHANGED	uphK.Lahu....sslccLpchsphh.pstpstshph.....hhpoApKlhcpA-cath-GD-EpAYlhYMKahslh.ptI+c+sDYpppcsph+phLGssphpchhhsp....hEcLppSLppRYcpt	.....................t..............plctLsphu.ps...h.ph...s...pshsh..+p........YhRousclh+tAphYtpEGshEpAYlLYh+ahsLhhcplspH.Da+..p.st...s..+p........th....p......p....hpch....h..h.c.........hEpL+...tpLht+Yp..............................................	0	71	118	194
+8802	PF08970	Sda		Sporulation inhibitor A	Mistry J, Sammut SJ	anon	pdb_1pv0	Domain	Members of this protein family contain two antiparallel alpha helices that are linked by a highly structured inter-helix loop to form a helical hairpin; the structure is stabilised by numerous hydrophobic and electrostatic interactions. These sporulation inhibitors are antikinases that bind to the histidine kinase KinA phosphotransfer domain and act as a molecular barricade that inhibit productive interaction between the ATP binding site and the phosphorylatable KinA His residue. This results in the inhibition of sporulation (by preventing phosphorylation of spo0A) [1].	21.10	21.10	21.50	27.00	20.50	18.10	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.06	0.72	-4.47	18	164	2009-01-15 18:05:59	2006-08-03 16:19:17	5	1	141	4	36	93	1	45.20	58	91.48	CHANGED	Mcp...LSDELLhESYaKApELpLsPDFItLIcpEIhRRSLpcKlshSS	......Mcp...LSsELLhESYaKApEL+LssDFIhLIcpEIhRRSLccplshSS........	0	11	26	28
+8803	PF08971	GlgS		Glycogen synthesis protein	Mistry J, Sammut SJ	anon	pdb_1rrz	Domain	Members of this family are involved in glycogen synthesis in Enterobacteria. The structure of the polypeptide chain comprises a bundle of two parallel amphipathic helices, alpha-1 and alpha-3, and a short hydrophobic helix alpha-2 sandwiched between them [1].	24.20	24.20	24.40	24.20	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.28	0.72	-4.05	4	480	2009-09-13 10:19:12	2006-08-03 16:20:08	6	1	476	1	21	81	0	65.20	75	97.93	CHANGED	M.D+slYShsNFDFLApSFARMpuEGR.VDItAVTGNMsEuppsWFpcRYuaYpQQhhQtpthplEH	...........M.ccsl.SLNNFDFLARSFARMHAEGRPVDIhAVTGNMDEEHRTWFCARYAaYCQQhhQARELELEH..........	0	1	4	12
+8804	PF08972	DUF1902		Domain of unknown function (DUF1902)	Mistry J, Sammut SJ	anon	pdb_1wv8	Domain	Members of this family of prokaryotic proteins adopt a fold consisting of one alpha-helix and four beta-strands. Their function has not, as yet, been elucidated [1].	29.40	29.40	29.80	29.50	29.30	28.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.71	0.72	-4.41	8	55	2012-10-02 16:06:15	2006-08-03 16:21:41	6	1	52	1	31	65	2	53.10	39	65.57	CHANGED	lpIQAsWDsEAGVWVApSDDlPGLlTEA-TlEtLhcKlpsMlPDLLp-Nusspt	.............htlcshWDpEAsVWVApSsDl...PGLsTEAsTl-sLhpKlpshIs-LLphNt....t.......	0	7	16	21
+8805	PF08973	TM1506	DUF1893;	Domain of unknown function (DUF1893)	Mistry J, Sammut SJ, Iyer, LM	anon	pdb_1vk9	Domain	A member of the deaminase fold that binds an unknown ligand in  the crystal structure. The protein is ADP-ribosylated at a conserved aspartate [1]. Contextual analysis suggests that the domain  is likely to bind NAD or ADP ribose either to sense redox states or to function as a regulatory ADP ribosyltransferase [2].	20.50	20.50	20.80	29.90	18.30	20.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.56	0.71	-4.62	9	122	2009-01-15 18:05:59	2006-08-03 16:24:45	5	3	117	1	18	93	1	129.50	36	76.92	CHANGED	M-p.....hhclLccGGYShVlhp-pc.lpT.spRGltsLh-L...lpppsp.hcGAtlADKVlGKAAAhLhlhGGl+plYAclISpsAlclLcpssIcssYschVPaIhNRstoGhCPlEphsh-l-sscchaclIppFlpK	...........................p.....hhphLpptshohslhpc.pc..lho.ppRGltsLh-l....lspt.p....hcGup.lsDKVVGKAAAslhlhuGlppVaAsllSpsAhclLcptuIcVsapchVshI..s.RstsshCPhEshs.pl-ssEEhhthl.t...........	1	10	16	16
+8806	PF08974	DUF1877		Domain of unknown function (DUF1877)	Mistry J, Sammut SJ	anon	pdb_1ryl	Domain	This domain is found in a set of hypothetical bacterial proteins.	22.00	22.00	22.80	22.40	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.06	0.71	-4.59	16	510	2009-01-15 18:05:59	2006-08-03 16:27:53	5	2	476	2	63	275	3	158.20	50	98.00	CHANGED	MGMhspYhplsccclpcLh..st............stpshhphht-htpsp...........................phDl-KtWcsLHalLTGsss..........ppssPlu.slhGs..psht.-ss.s..sphhsssclpplsctLpslshcpLhppFshpphppsclYPs.h.p.pptcp-hh-plhphatcLpcFapcsucpspslLlhI	.....................................................................................................MGMIGhascIcsEclspLL....co.................................sccsLhD.sIcD...shsshc.........................................cLDIDKpWDhLHFsLTGoSAh.............-PscNDPLS+AVLGE...........cSL.....E..Du...l...DG..F...luLThspElAusl-+LEuLDcsELRKp......F......Sl...........K+Ls......Eh.E......I......YPG..l........shsEEh.E..up..l...F..us..Ihh.chEKLluhY++hL+pGspsLssI.............................	0	28	46	56
+8807	PF08975	2H-phosphodiest	DUF1868; 	Domain of unknown function (DUF1868)	Mistry J, Sammut SJ	anon	pdb_2fsq	Domain	This group of 2H-phosphodiesterases comprises a single family typified by the protein mlr3352 from M.loti. Members are also present in various alpha-proteobacteria, Synechocystis, Streptococcus and Chilo iridescent virus. The presence of a member of this predominantly bacterial group in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses (L.M.Iyer, E.V.Koonin and L.Aravind, unpublished observations and these appear to have been acquired from endo-symbiotic or parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for these proteins in regulating the viral tRNA metabolism. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family.	21.00	21.00	21.30	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.52	0.71	-4.34	13	265	2012-10-03 21:31:48	2006-08-03 16:30:44	5	1	258	1	37	106	81	117.50	61	51.47	CHANGED	KFspsGchhPhsGNTlVCHL-psusshp...slLshppphhshshAs+hsFhPsSShHMTlFpGlh-pcRpsshWPucLPlDsslschsshatpRLcsFsh..sssFphtl......ssspP.tulhL	...KFKENGEFNHFPGNTVVAN..LYTK..Q.DLME....VVDIIQSRYRELP..FI.DK.FT.L.TPRNSIHMTVIELLCHENRETEFWSSNLPLDTPLQEIHDYFAKQLEIFPL......LDEEIHMRl......TEMGK.QNIL.V.........................................	1	5	17	22
+8808	PF08976	DUF1880		Domain of unknown function (DUF1880)	Mistry J, Sammut SJ	anon	pdb_1wlz	Domain	This domain is found predominantly in DJ binding protein. It has no known function.	21.30	21.30	22.30	21.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.54	0.71	-3.97	2	37	2009-01-15 18:05:59	2006-08-03 16:31:47	6	21	27	4	18	46	0	116.30	52	9.47	CHANGED	lQILTDEQFDRLWsEhPVNAKGRLKY.DFLS+hS.Epsso.PMAsGD...SshAQRGSSsP-hSpGTRSsL..Psp-.RsG.KSpSHPCTPs......GTPPLQNC-PIESRLRKpIQGCWR	..............................................................................................................lQlLTDEQFDRLWsEMPVNAKGRLKY.DFLS+FSoEcs.s....T...Ph..AsGD.......Ssh.AQ.RGSSV.P-lS...pusR...SAlSs.Psp-hRsG.KspS...H.P.CT.....Pustt..shsGoPPLQNC-PIES+LRK+IQGCWR......................................	0	3	3	6
+8809	PF08977	BOFC_N		Bypass of Forespore C, N terminal	Mistry J, Sammut SJ	anon	pdb_2bw2	Domain	The N-terminal domain of 'bypass of forespore C' is composed of a four-stranded beta-sheet covered by an alpha-helix. The beta-sheet has a beta2-beta1-beta4-beta3 topology, where strands beta1 and beta2 and strands beta3 and beta4 are connected by beta-turns, whereas strands beta2 and beta3 are joined by an alpha-helix that runs across one face of the beta-sheet. This domain is similar to the third immunoglobulin G-binding domain of protein G from Streptococcus, the latter belonging to a large and diverse group of cell surface-associated proteins that bind to immunoglobulins. It has been hypothesised that this domain may be a mediator of protein-protein interactions involved in proteolytic events at the cell surface [1].	25.00	25.00	26.80	26.40	24.70	20.60	hmmbuild  --amino -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.36	0.72	-4.15	10	128	2009-01-15 18:05:59	2006-08-03 16:36:58	5	2	128	1	18	85	0	50.80	61	29.42	CHANGED	lollLE+lYLDGEVSEEp+sETVhohEDFWupY+sWpLV-hc-splVFRKp	..VTILLERMYVDGEVSEEIhTEKVssLEcFLQQYKEWQLVDRDDsQIVLQKK..	0	3	10	12
+8810	PF08978	Reoviridae_Vp9		Reoviridae VP9	Mistry J, Sammut SJ	anon	pdb_1w9z	Domain	This domain is found in various VP9 viral outer-coat proteins. It has no known function.	19.00	19.00	28.90	21.30	17.60	16.50	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.84	0.70	-5.44	2	12	2009-01-15 18:05:59	2006-08-03 16:39:53	5	1	5	3	0	10	0	187.80	64	93.29	CHANGED	MlS-s.lRuhK+LuhpTpRssG-pThtLsSpVKLSKGEVEhlAVTKcEhh-tLtQCNL.plE.lsh-tTFNGslhRhuAahFlhpu.hlhhspslAVp.s.pYuTslAG.shphT.VhssphhhhtplstGs.usPaSspsuuLhIT.thsLhss.l.sGplhVLF.TSL.TThspoNSaAYShCslPhpcWD.phIKLTuETSCsSLsuMpsLsNSll.G-Rs.ssGLYVDI.GVTVoTSsS.uoLPlTslssshPlhFpAhs+.VEpVu.INhLYsLu	.......................................................................................................................................................................................................................WDFNMIKLTAETSCsSLTtMTNhlNoLV.GDRsRPVGLaVDIPGVTVTTSASluoLPITTIPAsTPLIFSAYhKQVEEVGlINTLYuLS...	2	0	0	0
+8811	PF08979	DUF1894		Domain of unknown function (DUF1894)	Mistry J, Sammut SJ	anon	pdb_1z9v	Domain	Members of this family have an important role in methanogenesis. They assume an alpha-beta globular structure consisting of six beta-strands and three alpha-helices forming the secondary structural topological arrangement of alpha1-beta1-alpha2-beta2-beta3-beta4-beta5-beta6-alpha3 [1].	25.00	25.00	26.20	59.70	23.60	16.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.05	0.72	-3.93	20	55	2009-01-15 18:05:59	2006-08-03 16:42:58	6	2	46	1	42	54	1	91.30	39	87.56	CHANGED	M.u.Cl-sh.....sYEILL+psoFKECc-aI+cpscElYclpPGaclh.GlhlIGhsPIPVGlcs..s.slIFPYTKPC..aGoFVl+l..pss.-Elc+lRc	...Mu.Cl-ph.....sYEILL+stoFKECp-aI+cshcElhclsPGhclh.GlhlIGlPPIPlGl-s...s.pllFPYTKPC..aGTaVl+l..pss.cElc+lR..............	0	10	27	35
+8812	PF08980	DUF1883		Domain of unknown function (DUF1883)	Mistry J, Sammut SJ	anon	pdb_2b1y	Domain	This domain is found in a set of hypothetical bacterial proteins.	21.00	21.00	21.50	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.15	0.72	-4.45	10	161	2009-01-15 18:05:59	2006-08-03 16:45:37	5	3	155	1	48	116	3	87.50	35	79.80	CHANGED	M+Fs.Y-hcph+cG-llsloLs.pssNVRLMssuNFppF+NstcapY.hGGhsc+SPs+IsVPSoGaWhlllDh..sGp+Ghlsuol+...s..th..clhR	.........hpah.aphtphptuDlVVlcCS.ppCNI+LMsssNFppa+sGscasY.hG..Gshc+.PA+lsVPpoGaWslsIDo..tupp...hphohp.............hh...............	0	9	16	33
+8814	PF08982	DUF1857		Domain of unknown function (DUF1857)	Mistry J, Sammut SJ	anon	pdb_2ffs	Domain	This domain has no known function. It is found in various hypothetical bacterial and fungal proteins.	21.30	21.30	24.70	24.50	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.68	0.71	-4.61	17	171	2012-10-02 19:24:03	2006-08-03 16:54:50	6	4	160	2	79	146	10	151.00	33	88.30	CHANGED	papahl.lNsPss.thssLTRpQlWpGLlh+ucpPp.Fls.ul.-pCpllpcs........sstltRcLpa.........GsthlcDpVpht..pplca.....tptsGuolshhI-.......-sssusLaLRFhYchphs.hpssut-.cth..p-hh+pua+tushcTl+hIRphstsGp	...............pFEHLlplNssss..thssLTRsQlWpGLVhRAcpPphFV..GL.-sCtlhpcs.............sstlcR-Lpa................Gps.sl+DcVThpssp.pVcaph..sssttsGu...oLohsIE.......E.s.-..st.pLFlRFtYcTsls....h.pss.ot-tpph..pphlKpAY+puDl-Tl.chIR-hstt..............................	0	10	41	64
+8815	PF08983	DUF1856		Domain of unknown function (DUF1856)	Mistry J, Sammut SJ	anon	pdb_1ytv	Domain	This domain has no known function. It is found in the C-terminal segment of various vasopressin receptors.	25.00	25.00	30.70	29.60	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.47	0.72	-3.87	9	110	2009-09-11 07:47:04	2006-08-03 16:57:04	5	1	65	0	32	102	0	46.40	58	11.36	CHANGED	shpKEDSDSSh..RRpT.hT+h.ssRoPosuh......ssWK...sSPKSScSl+hl.hpp	.cFsK-DSDShS..RRQT.ao...NNR.SPTNSo......GhWK...-SPKSS+Sl+FlPlsT.............	0	1	4	14
+8816	PF08984	DUF1858		Domain of unknown function (DUF1858)	Mistry J, Sammut SJ	anon	pdb_2fi0	Domain	This domain has no known function. It is found in various hypothetical bacterial proteins.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.71	0.72	-4.31	33	1114	2009-01-15 18:05:59	2006-08-03 16:58:53	6	29	835	3	232	793	11	56.80	29	33.48	CHANGED	Ishshslt-llcpaP-sl-lhhph..GFpplssPshhpohu+hhTLcpuuphtslslsplh	...............Ishshslu-llcpa....P....-..ll.-lLhch...GhcsLusPh.....u.phhoLcpuuphcGlsh-clh..........	0	110	183	204
+8817	PF08985	DUF1888		Domain of unknown function (DUF1888)	Mistry J, Sammut SJ	anon	pdb_1ai4	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	31.70	31.40	23.10	22.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.54	0.71	-4.44	4	33	2009-09-11 00:41:11	2006-08-03 17:02:49	6	1	32	21	10	34	5	121.90	49	94.95	CHANGED	Mpss.spspaIpVTVTLE.NGEPVFsYTsApGt.p.GDVslTpuuT.ITY.LpDQTGKGLKFVGAuFhTPFDplIDAVplSoDGpLlpLsDLDcssGsTpFQFVLoNouNTLhlLSPDPplIN+sp	........M.ss.t.upalpVsVTLE.NGEPV.F.YTcss.Gc..ts.sGDVTlTpuuT.lTYhL..sDpT.G.K.GLKFVGsGFl.....TPFDp....ll....D..AVTlSoD..GhLlQLVDhDcoPGoTKFQFVhoNosNTLllLSPDPplIN+s.p..	0	2	3	5
+8818	PF08986	DUF1889		Domain of unknown function (DUF1889)	Mistry J, Sammut SJ	anon	pdb_2es9	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	53.20	53.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.73	0.71	-3.92	2	354	2009-01-15 18:05:59	2006-08-03 17:04:34	5	1	350	2	10	76	1	99.00	87	99.77	CHANGED	MQIKVIYSLIDNMVNFKDKNMPAVIDKALDFIGAMDVSAPTPSSMNESTAKGIFKYLKELGVPASAADITsRAD.EGWNPGFTEKMVGWAKKMEoGER.VIKNPEYFSTYMQEELKALV	...................................MPAVIDKALDFIGAMDVSAPTPSSMNESTAKGIFKYLKELGVPASAADITARADQEGWNPGFTEKMVGWAKKMEoGERsVIKNPEYFSTYMQEELKALV.......	0	1	1	6
+8819	PF08987	DUF1892		Protein of unknown function (DUF1892)	Mistry J, Sammut SJ	anon	pdb_1n6z	Family	Members of this family, that are synthesised by Saccharomycetes, adopt a structure consisting of a four-stranded beta-sheet, with strand order beta2-beta1-beta4-beta3, and two alpha-helices, with an overall topology of beta-beta-alpha-beta-beta-alpha. They have no known function [1].	19.90	19.90	21.10	60.70	19.10	17.50	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.58	0.71	-4.07	9	44	2009-01-15 18:05:59	2006-08-03 17:08:24	5	2	42	1	28	38	0	110.00	45	85.71	CHANGED	Must..............-NshRhlllL-cs....ppcpsptDc+...........hlDE......VpphDplNpaFDKFDEcIsIPNEGHIKYEluSDGLlVlIlD.KEl.-cVlshVcsasppsp.cppctpD	................h.ut..............sNsaRhllLLE-...................cp..c.....s...c.-E+................p-FlDE.....tlsphDplNpWFDKFDpcICIPNEGHIKYEluSDGLlVlllD.+El.--VlchVccaVccs.........p..............	0	3	14	25
+8820	PF08988	DUF1895		Protein of unknown function (DUF1895)	Mistry J, Sammut SJ	anon	pdb_1zw0	Family	The YscE protein, produced by the pathogen Yersinia, assumes a secondary structure composed of two anti-parallel alpha-helices separated by a flexible loop. The function of this protein is, as yet, unknown [1].	21.80	21.80	22.30	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.19	0.72	-3.94	5	99	2009-01-15 18:05:59	2006-08-03 17:10:32	5	1	94	16	12	42	2	66.40	37	86.26	CHANGED	MTsLEppLpu.ussppVcsIpp+LpQAQucVKRQLcpGGsPQQYQlWp+Qu-AlpAAlsIIcTlEucpK	.......MTpLEphLps..sspps+uIphpLctAhspl++phs+GssPpQYQ.hppphcAlEuAhsIIphht............	0	4	6	7
+8821	PF08989	DUF1896		Domain of unknown function (DUF1896)	Mistry J, Sammut SJ	anon	pdb_2apl	Domain	This domain is found in a set of hypothetical bacterial proteins.	25.00	25.00	26.30	26.10	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.80	0.71	-4.32	7	270	2009-01-15 18:05:59	2006-08-03 17:11:53	5	1	103	1	19	217	4	140.40	50	90.90	CHANGED	hsppppELSYa+LtLLsYL+EsHPchAGDpsFIppRu-pAAcsYpcAltpGhshstAtphAptlLhpGLHFS+YDslhpVl.sEFtsEVPptptcshsLpLL..P.scsVFs+YslsDD.FphSPpYcpLYsELTGsIhhhlEc.Gl	........................h.ppspp-hSYatLpL.sYLp-p+PEphsD......psFIptRADpAhpsYpcAhtpGastspApphAp-lLapGLHFS+YDTLhpVlENEFpcE....lPsshsEphs.hLL....hlpsVFs+Y-..LoDD.FAhos-Y-pLYTELTGslVLhIEppGl..........	0	8	15	19
+8822	PF08990	Docking		Erythronolide synthase docking	Mistry J, Sammut SJ	anon	pdb_1pzr	Domain	The N terminal docking domain found in modular polyketide synthase assumes an alpha-helical structure, wherein two alpha-helices are connected by a short loop. Two such N-terminal domains dimerise to form amphipathic parallel alpha-helical coiled coils: dimerisation is essential for protein function [1].	20.90	20.90	21.00	21.30	20.20	20.70	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.57	0.72	-7.08	0.72	-4.70	141	653	2009-01-15 18:05:59	2006-08-03 17:16:00	6	165	190	6	148	643	1	26.80	48	0.94	CHANGED	MssE-KLh-YLKRlTuDL+psRpR.L+-	.....ss--KLh-YLKRlTuDL+coRpRLpE....	1	24	106	140
+8823	PF08991	DUF1903		Domain of unknown function (DUF1903)	Mistry J, Sammut SJ	anon	pdb_1hp8	Domain	Members of this family adopt a coiled coil structure, with two antiparallel alpha-helices that are tightly strapped together by two disulfide bridges at each end. The protein sequence shows a cysteine motif, required for the stabilisation of the coiled-coil-like structure. Additional inter-helix hydrophobic contacts impart stability to this scaffold. The precise function of this eukaryotic domain is, as yet, unknown [1].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.78	0.72	-3.82	7	194	2012-10-02 15:44:21	2006-08-04 08:57:27	5	3	149	3	132	223	0	59.70	30	66.44	CHANGED	psPCptpACAIQsCLptstYsEu+CtslI--LhpCCtpa......cu+SlCCst.pl.....lphc...hpptpK	...........sPCptpAC...t.lQ.pCLp...cNsY.....scs+CpphlptlpcCCppa.t.......ptpo..Cs..t......................t.............................	0	33	70	107
+8824	PF08992	QH-AmDH_gamma		Quinohemoprotein amine dehydrogenase, gamma subunit	Mistry J, Sammut SJ	anon	pdb_1jmx	Domain	Members of this family contain a cross-linked, proteinous quinone cofactor, cysteine tryptophylquinone, which is required for catalysis of the oxidative deamination of a wide range of aliphatic and aromatic amines. The domain assumes a globular secondary structure, with two short alpha-helices having many turns and bends [1].	25.00	25.00	92.90	92.20	19.80	18.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.98	0.72	-4.22	9	37	2009-01-15 18:05:59	2006-08-04 08:59:52	6	1	32	4	14	41	1	77.80	67	75.10	CHANGED	suVVGCToThDPGWEVDuFGGVuuLCQPMEADLYGCuDPCWWPAQVPDThsoYPcWupcAsssspDWRpLsoVFPpsK	..............suVsGCTsThDPGWEVDuFG.GVuSLCQPMEADLYGCSDPCWWPAQVPDhhsoY.DWsspAssuscDWRpLsoVFPcs....	0	2	9	11
+8825	PF08993	T4_Gp59_N	T4-helicase_N;	T4 gene Gp59 loader of gp41 DNA helicase	Mistry J, Sammut SJ	anon	pdb_1c1k	Domain	Bacteriophage T4 gene-59 helicase assembly protein is required for recombination-dependent DNA replication, which is the predominant mode of DNA replication in the late stage of T4 infection. T4 gene-59 helicase assembly protein accelerates the loading of the T4 gene-41 helicase during DNA synthesis by the T4 replication system in vitro. T4 gene-59 helicase assembly protein binds to both T4 gene-41 helicase and T4 gene-32 single-stranded DNA binding protein, and to single and double-stranded DNA. The structure of T4 gene-59 helicase assembly protein reveals a novel alpha-helical bundle fold with two domains of similar size, this being the N-terminal domain that consists of six alpha-helices linked by loop segments and short turns. The surface of the domain contains large regions of exposed hydrophobic residues and clusters of acidic and basic residues. This domain has structural similarity to members of the high-mobility-group (HMG) family of DNA minor groove binding proteins including rat HMG1A and lymphoid enhancer-binding factor, and is required for binding of the helicase to the DNA minor groove [1].	21.10	21.10	21.80	22.20	20.00	21.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.05	0.72	-3.98	8	64	2009-01-15 18:05:59	2006-08-04 09:01:32	5	2	62	1	0	53	451	91.20	41	44.10	CHANGED	lsuhuVY+LYLshKsHhsG.KYDhlKYpWp.hRso-sAFpKR+DKYFFcKLAcKaoLpElhtlhluNhlANscu...WlG-IsssDAhsFYtcalG+hc	...puhsVYplYLhlKpHFss.+YDhlKYshp.h+sS.-suapKR+D+YFFpKLucKaph+..E.Lt.hFluNhVsNscu...WlG-lsstDAhshYp-als+h.p............	0	0	0	0
+8826	PF08994	T4_Gp59_C	T4-helicase_C;	T4 gene Gp59 loader of gp41 DNA helicase C-term	Mistry J, Sammut SJ	anon	pdb_1c1k	Domain	Bacteriophage T4 gene-59 helicase assembly protein is required for recombination-dependent DNA replication, which is the predominant mode of DNA replication in the late stage of T4 infection. T4 gene-59 helicase assembly protein accelerates the loading of the T4 gene-41 helicase during DNA synthesis by the T4 replication system in vitro.  T4 gene-59 helicase assembly protein binds to both T4 gene-41 helicase and T4 gene-32 single-stranded DNA binding protein, and to single and double-stranded DNA. The structure of T4 gene-59 helicase assembly protein reveals a novel alpha-helical bundle fold with two domains of similar size, this being the C-terminal domain that consists of seven alpha-helices with short intervening loops and turns. The surface of the domain contains large regions of exposed hydrophobic residues and clusters of acidic and basic residues. The hydrophobic region on the 'bottom' surface of the domain near the C-terminal helix binds the leading strand DNA, whilst the hydrophobic region on the 'top' surface of the domain lies between the two arms of the fork DNA, allowing for T4 gene 41 helicase binding and assembly into a hexameric complex around the lagging strand [1].	25.00	25.00	64.70	63.90	21.70	21.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.07	0.72	-3.87	10	58	2009-01-15 18:05:59	2006-08-04 09:03:10	5	2	56	1	0	50	390	101.80	38	50.40	CHANGED	F+EDl+slhYFucKhsls.hcclFpYspcspoShIFKLlQoshIShETFllLDSFLsIlD+aDc.hssDllWps.apsKlpAY+KLlsIDsc...pAKslFIcslcppK	......................Fc-DlcslhhFucpsthpthcclFp.sscsppshIhKhlQSshIShETFllLDShLshl-caDc.ptsDllWps.auhKlpuY+KlLsIDsp...csKplFl-Tl+sh....	0	0	0	0
+8827	PF08995	NIP_1		Necrosis inducing protein-1	Mistry J, Sammut SJ	anon	pdb_1kg1	Domain	Necrosis inducing protein-1, a fungal avirulence protein produced by plants, consists of two parts containing beta-sheets of two and three anti-parallel strands, respectively. Five intramolecular disulfide bonds, stabilise these parts and their position with respect to each other, providing a high level of stability [1].	25.00	25.00	186.20	186.00	20.10	18.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.14	0.72	-3.81	3	16	2009-01-15 18:05:59	2006-08-04 09:05:11	5	1	1	1	0	17	0	82.00	96	100.00	CHANGED	MKFLVLPLSLAFLQIGLVFSTPDRCRYTLCC-GALKAVSECLHESESCLVPGDCCRGKSRLTLCSYGEGGNGFQCPTGYRQC	MKFLVLPLSLAFLQIGLVFSTPDRCRYTLCCDGALKAVSECLpESESCLVPGDCCRGKSRLTLCSYGEGGNGFQCPpGYRQC	0	0	0	0
+8828	PF08996	zf-DNA_Pol		DNA Polymerase alpha zinc finger	Mistry J, Sammut SJ	anon	pdb_1n5g	Domain	The DNA Polymerase alpha zinc finger domain adopts an alpha-helix-like structure, followed by three turns, all of which involve proline. The resulting motif is a helix-turn-helix motif, in contrast to other zinc finger domains, which show anti-parallel sheet and helix conformation. Zinc binding occurs due to the presence of four cysteine residues positioned to bind the metal centre in a tetrahedral coordination geometry. Function of this domain is uncertain: it has been proposed that the zinc finger motif may be an essential part of the DNA binding domain [1].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.62	0.71	-4.94	40	326	2009-01-15 18:05:59	2006-08-04 09:06:55	5	14	267	7	211	330	1	179.70	29	13.00	CHANGED	l-opl.oDsp+a+ssspLplpC..spCspphhFsG...........lhs.......ssstphpssGlpCsp......Cst..hhsshpltsQLphtIRpalshYYpGWllC--ssCss+.TRQlslhu+R....Cl......................sC.+GpMph-Yo-+pLYNQLhYapuLFDl-+shppthp..................pptptcpl.hhspps+phappl+ssV-caLscsGhphVshu.slF	................................................................................sph.sDp.+a+sspthphpC.....p..Ctpp.has.u........................lhp......................tsspt.h..p..ss...h...h..tCsp......Cpt...............hh.s..hplsspLphplRphl.pcYY.pG.WL.lC-DssC...s..p.c...TRp..hsl..hs.p.R..................C.............................sC..pGphp..hcYo-+pLYsQLhYapt.lFDs-pshpph.t............................tttp.ppph..hh.s.tp.p.....thattlpsslc.phLpcsuhphVshsplF................................	1	74	116	172
+8829	PF08997	UCR_6-4kD		Ubiquinol-cytochrome C reductase complex, 6.4kD protein	Mistry J, Sammut SJ	anon	pdb_1sqq	Domain	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is an essential component of the mitochondrial cellular respiratory chain. This family represents the 6.4kD protein, which may be closely linked to the iron-sulphur protein in the complex and function as an iron-sulphur protein binding factor [1].	24.00	24.00	24.10	24.60	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.68	0.72	-4.26	5	96	2009-01-15 18:05:59	2006-08-04 09:08:46	5	2	70	17	55	108	0	53.60	42	80.45	CHANGED	Mlo+l.lGsKYsElA+uWlPoussWGuAGGVALVaFTDWRLlLDYVPYlNuKFcKDE	...........hh.+h.hG.+ahplspsWlPosusaGusuuluLlahTD.W..+LILsaVPahsGKFccs......	0	16	18	33
+8830	PF08998	Epsilon_antitox		Bacterial epsilon antitoxin	Mistry J, Sammut SJ	anon	pdb_1gvn	Domain	The epsilon antitoxin, produced by various prokaryotes, forms part of a postsegregational killing system which is involved in the initiation of programmed cell death of plasmid-free cells. The protein is folded into a three-helix bundle that directly interacts with the zeta toxin, inactivating it [1].	25.00	25.00	43.50	42.80	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.08	0.72	-4.01	3	79	2009-09-10 22:13:13	2006-08-04 09:09:58	6	2	68	4	1	25	0	85.90	77	95.90	CHANGED	AVTYEKTFEIEIINELSuSVYNRVLNYVLNHELDKsDSpLLEVNLLNQLclApcVNLFchSLEELQAlHEYWRSMN+YSKQILsKEKVA	.AVTYEKTFEIEIINELSASVYNRVLNYVLNHELsppDopLLEVNLLNQLclApcVsLFp.shEELQAlHEYWRSMNpYSKQlLsKEKVA...................	0	0	0	1
+8831	PF08999	SP_C-Propep		Surfactant protein C, N terminal propeptide	Mistry J, Sammut SJ	anon	pdb_2esy	Domain	The N-terminal propeptide of surfactant protein C adopts an alpha-helical structure, with turn and extended regions. It's main function is the stabilisation of metastable surfactant protein C (SP-C), since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid-like fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide [1].	25.00	25.00	28.30	27.80	23.00	21.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.27	0.72	-4.50	3	104	2009-01-15 18:05:59	2006-08-04 09:13:37	5	3	70	7	22	92	0	62.70	80	51.94	CHANGED	MDMGSKEVLMESPPDYSAuPRGRFRIPCCPVHLKRLLIVVVVVVLVVVVIVGALLMGLHMSQKHTEMVLEMSIGG.PEsQQRLALSE+sGTTAT	..................................FtIPCCPVpLKRLLIVVVVVVLVVVVIVGALLMGL...................................................	0	1	1	5
+8832	PF09000	Cytotoxic		Cytotoxic	Mistry J, Sammut SJ	anon	pdb_1e44	Domain	The cytotoxic domain confers cytotoxic activity to proteins, enabling the formation of nucleolytic breaks in 16S ribosomal RNA. The structure of the domain reveals a highly twisted central beta-sheet elaborated with a short N-terminal alpha-helix [1].	21.10	21.10	21.10	22.90	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.00	0.72	-3.96	5	56	2009-01-15 18:05:59	2006-08-04 09:15:10	5	19	47	6	17	71	1	81.20	38	15.33	CHANGED	YHPAPKsptlsGLssL..+.stpKTPhQuGGuKRKRWpssKG....++IYEWDSpHGElEVYc.S+G+HLGShDPpTG-.lKssV+GRoIKt.l	.............................t....l.uhsth....st.KTs..hpGGGshRtR...WhspKG......cpIYEWDSQH....G....clEsYc..pcGc.HLGpFDPpTGcpl..Ks.ss..tRplc.h...............	0	4	6	11
+8833	PF09001	DUF1890		Domain of unknown function (DUF1890)	Mistry J, Sammut SJ	anon	pdb_1kjn	Domain	This domain is found in a set of hypothetical archaeal proteins.	25.00	25.00	136.10	135.90	24.70	19.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.73	0.71	-4.17	14	40	2009-01-15 18:05:59	2006-08-04 09:16:13	6	1	39	2	30	39	2	141.30	40	93.70	CHANGED	llllGCPEsPVQhshslYLsptLcctGhclllAuNPAAh+LlcVADP-+aYlcch..h-lDcsltplttt..sh-hhhuFsHNDAulsYssTh.ttl.pscshullFG+c.s--Lscplp.....hssphlsu+AhHNPhPLps+l-clh	LllLGCPEsPlQsPhslYLsptL+ccGacVslAuNPAAhKLlcluDPE+aYlppl..h-lDcslpslttt..-hDhlhuFlHNDAuloYhsTa.ptlhpsc.shAlVFG+c.s--Lschlc....thsschlsuRAaHNPtPLps+l-+lh...	0	7	19	25
+8834	PF09002	DUF1887		Domain of unknown function (DUF1887)	Mistry J, Sammut SJ	anon	pdb_1xmx	Domain	This domain is found in a set of hypothetical bacterial proteins.	23.90	23.90	23.90	23.90	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.31	0.70	-6.06	6	279	2012-10-11 20:44:44	2006-08-04 09:20:15	6	6	251	1	59	213	19	305.10	28	86.60	CHANGED	MtlHVslls.QcsspLIssLLDpth+sc+hVFIsocsp..+EthpRLcplLp.pGIss....-hFplsstsshptl+pplpsLhE-hKh.ssElhLNsosGh+hhhLuAYEsFR.ShHhPIahl-ssSDclpaL.PsGscptpV.pcpIp..luDYLssaGA......Rst.u-sphscphsc+LhpLupRaAosAh-hGshLuoLNhLAoss..R+tphlslclo-cptuY.+-LshLlsDLs-ssLssa-sGl.lTFtsE-ARRFhNGpWLEhhVaspl+sIpp....lpDhuLsVQVhcchsEKp...VRNELDVVslssNKLHIIECKTtGhccDu.....DDTLYKLESLRD.LGGLpuRuhLVSFRPlpssDlh..RApchsltlIGPDELsDLKcHLpsWhpts	.......................................................................................hhs.p....p.............th.s.p..chlhlh...sppt..........hhp.pL.p..p.hhp....h..th...p.............ch.hp.l.s.s..................shptlp...ptl.pp.lh.pphc........sccl..hhNhosGh+h..hhLusa.p.hh.p..php..h..s.....l.......h.hh-spps..p..h.hhl..ts...p....p....p..pl....sp.lp..ltshlshhGs.........p.th...p.........h......pht.p..hsp....h.......p....h...h...l................sph...h.tpps.......p......ph...p.th..ppp...t.hh...t.......p.l....l.s....L....ctt...h...h.....p.....h...p....pt....h.....h.....sF..s....c...p...h...+p......F..h..s..GpW.LEhhl.atpl.pphpp........l..pDhp...hs....l.....pl...h..hp.....h..t..-pc.................lpN....ELDVshh.h.ssp.L.hlIECKo.psh.....p..s-.s.............hLh+..Lpsh..tchhG.G.pscthL..Vs.h...t....hp....s.....h........Rspph...tl..l.l....tp.h..th...l.t....s...............................................................................	1	24	44	53
+8835	PF09003	Phage_integ_N		Bacteriophage lambda integrase, N-terminal domain 	Mistry J, Sammut SJ	anon	pdb_1kjk	Domain	The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage [1].	21.80	21.80	22.10	23.00	21.40	21.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.61	0.72	-4.27	17	707	2012-10-03 08:51:45	2006-08-04 09:34:33	5	9	359	8	34	331	1	71.50	43	19.78	CHANGED	MutRsRphs.hslP.NLhtp.s.+...sYapY+sPlTGK.aGLGp.D+ppAhspAhpANhplhpptscthLhpp.pss	..........MutR.Rpac..pclP.sLY.+.s....s....+s...YapYRcPlTGKpaGLGp.DcchAhs.AhpANpcltptptcphLshp.c.h.......................	0	7	19	27
+8836	PF09004	DUF1891		Domain of unknown function (DUF1891)	Mistry J, Sammut SJ	anon	pdb_2cq2	Domain	This domain is found in a set of hypothetical eukaryotic proteins.	20.60	20.60	20.60	20.70	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-8.06	0.72	-4.57	9	72	2009-01-15 18:05:59	2006-08-04 10:05:59	5	14	28	6	42	109	0	38.20	39	7.06	CHANGED	WosNpsulhKKAQQRLaFLRpL+Ksphs....shhh+usIES	.......hssNp....puhhKhuppchhFLRK.pKs+h......sLhh+psIEo....	0	13	14	30
+8837	PF09005	DUF1897		Domain of unknown function (DUF1897)	Mistry J, Sammut SJ	anon	pdb_2bn5	Domain	This domain is found in Psi proteins produced by Drosophila, and in various eukaryotic hypothetical proteins. It has no known function.	20.10	20.10	20.30	20.10	19.70	20.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.05	0.72	-4.50	12	369	2009-01-15 18:05:59	2006-08-04 10:08:04	5	23	86	2	175	293	0	32.50	48	8.58	CHANGED	ssssssGpsDYSApWhEYYRphGhhcpA-hlcpphtt.p	..........ssssuGQ.sDYSAAWtEYY+p..G...pAthhtt.....s............	1	36	48	112
+8838	PF09006	Surfac_D-trimer		Lung surfactant protein D coiled-coil trimerisation	Mistry J, Sammut SJ	anon	pdb_1m7l	Domain	This domain, predominantly found in lung surfactant protein D, forms a triple-helical parallel coiled coil, and mediates trimerisation of the protein [1].	20.70	20.70	20.70	20.80	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.22	0.72	-4.23	10	72	2009-01-15 18:05:59	2006-08-04 10:14:29	6	6	32	67	37	66	0	42.60	52	13.77	CHANGED	VsALRQQVEsLpGpLQRLQsAFSQYKKAsLFPDGQSVGEKIFKTAG	..................lsuL+QQlpsLptplppLQsuhSpYKKstLFPsGpuVGcKIFKTuG.....	0	1	1	6
+8839	PF09007	EBP50_C-term		EBP50, C-terminal	Mistry J, Sammut SJ	anon	pdb_1sgh	Domain	This C terminal domain allows interaction of EBP50 with FERM (four-point one ERM) domains, resulting in the activation of Ezrin-radixin-moesin (ERM), with subsequent cytoskeletal modulation and cellular growth control [1].	25.00	25.00	46.10	45.00	20.20	19.10	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.89	0.72	-4.10	6	149	2009-01-15 18:05:59	2006-08-04 10:16:42	6	4	37	9	55	106	0	40.90	60	12.56	CHANGED	-ssLcLshShAtAKE+A+.ppRupKRAPQMDWSK+pElFSNh	.....-ssLcl..u.osAtAKE+A+.tpRssKRAPQMDWsKKpElFSNh.	0	2	8	21
+8840	PF09008	Head_binding		Head binding	Mistry J, Sammut SJ	anon	pdb_1lkt	Domain	The head binding domain found in the Phage P22 tailspike protein contains two regular beta-sheets, A and B, oriented nearly perpendicular to each other and composed of five and three strands respectively. The topology of the strands is exclusively antiparallel. The tailspike protein trimerises through this domain, and the direction of the strands with respect to the molecular triad is almost parallel for beta-sheet A, whereas beta-sheet B is perpendicular to the triad, forming a dome-like structure. This domain is dispensable for thermostability and SDS resistance of the intact protein, and its deletion has only minor effects on tailspike folding kinetics [1].	21.50	21.50	24.60	23.60	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.47	0.71	-4.04	5	167	2009-09-11 14:20:10	2006-08-04 10:18:20	5	10	154	22	13	147	0	109.70	70	16.69	CHANGED	MTDITsNlVVSMPSQlFTtsRuFKAVANGKIYIGKIDTDPVNPsNQIPVYlENEDGSaVpVAQPIIINAAGaPVYNGQIAKFVTVQGHSMAVYDAsGAQQFYFsNVLKYDPcph	..........MoD.ITANVVVSMPoQLFTMuRSFKAVANGKIYIGKIDTDP...VNPpNQIpVYlENEDGSHVsVoQPIIINAAGaPVYNGQ.IAKFVTVQGHSMAVYD..AYGuQQFYFPNVLKYDPDQ..........	0	2	2	6
+8841	PF09009	Exotox-A_cataly		Exotoxin A catalytic	Mistry J, Sammut SJ	anon	pdb_1aer	Domain	Members of this family, which are found in prokaryotic exotoxin A, catalyse the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, with subsequent inhibition of protein synthesis [1].	25.00	25.00	26.80	36.00	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.62	0.70	-5.47	2	67	2009-01-15 18:05:59	2006-08-04 10:19:20	5	3	24	45	1	86	0	202.00	71	36.78	CHANGED	A.lphp..oGtpaLs-stsl.hospGspNWThpcL.tsHptLpccGYVFVGYHGT.h.AAQoIV..husV.Rupsp-.-thWtGhYlAscstlAaGYAp.pE.......PstttR.tpGshLRVYlPRuSL.tFYRTshsLtssEt..clpplIGHsLPLR.-AhTGPEptGGc.ETllGWshA.+sVsIPSsIPssshp.thslD.puls.KEQuISshPsY.....K..+--LK	ANINIESRSGRSYLPENRAV.ITPQGVTNWTYQELEATHQALTREGYVFVGYHGTNHVAAQTIVNRIAPVPRGNNTENEEKWGGLYVATHAEVAHGYARIKEGTG-hGLPTRAER-sRGVMLRVYIPRASLERFYRTNTPLENAEc..HITpVIGHSLPLRNEAFTGPEusGGEDETVIGWDMAIHAVAIPS............................................	0	1	1	1
+8842	PF09010	AsiA		Anti-Sigma Factor A	Mistry J, Sammut SJ	anon	pdb_1jr5	Domain	Anti-sigma factor A is a transcriptional inhibitor that inhibits sigma 70-directed transcription by weakening its interaction with the core of the host's RNA polymerase. It is an all-helical protein, composed of six helical segments and intervening loops and turns, as well as a helix-turn-helix DNA binding motif, although neither free anti-sigma factor nor anti-sigma factor bound to sigma-70 has been shown to interact directly with DNA. In solution, the protein forms a symmetric dimer of small (10.59 kDa) protomers, which are composed of helix and coil regions and are devoid of beta-strand/sheet secondary structural elements [1].	25.00	25.00	25.90	77.90	22.00	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.01	0.72	-4.11	6	30	2009-01-15 18:05:59	2006-08-04 10:21:43	5	1	29	6	0	23	0	88.50	46	97.68	CHANGED	M........Nts.Ehl+-IIuhASlLIKFupE.DIlssQpsFluFLNElGh+ossGc-FTpsSFRQMhsRLst-p+cELl-pFN.pGacslh+phhMYoNs	...MshplEhV+EIIolASILIKFupE.DIl-sRssFIAFLNElGl+s.pG+cLspsSFRclhpcLTp--+cpLI-EFN.pGa.EslaRhLhMYos.....	0	0	0	0
+8843	PF09011	HMG_box_2	DUF1898;	HMG-box domain	Mistry J, Sammut SJ, Coggill P	anon	pdb_2cto	Domain	This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail [1].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.46	0.72	-3.61	10	1103	2012-10-02 14:16:02	2006-08-04 10:25:46	5	49	229	12	522	7615	215	70.30	37	19.76	CHANGED	PsKPKushsAYhaFspcppsEhK+c......tP..ssshuEhoKtsSpcW+shSscEKccYp-pA+tcKscacpEhtsac	........................................KP..+..s.t.h.Su.Y.s.hF....lp.s....p....p....p....-....t.Kcc........................ps.......slsh..u.Eh..s..K.....c...C..S..E.+.................W..K..........s...h..Ss........c........E...Ksc..a...c.-....h...A+.....t...D..K.t.+.Y.-pEMpsa.h...................................	0	146	190	303
+8844	PF09012	FeoC	DUF1920; 	FeoC like transcriptional regulator	Mistry J, Sammut SJ	anon	pdb_1xn7	Domain	This family contains several transcriptional regulators, including FeoC, which contain a HTH motif.  FeoC acts as a [Fe-S] dependant transcriptional repressor [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.29	0.72	-4.27	36	803	2012-10-04 14:01:12	2006-08-04 09:28:13	5	3	792	2	109	876	60	71.10	45	86.96	CHANGED	hLppl+palppcspsShs-Lup+Fphs.sslcuMLshWlpKG+lp+h.sssss.....uuuCpp......Ct.....tt.p....shYc	..................SLlQVRDh..LA.L.+.GR.h-AsQISppLs..sPpPhIsAMLppLEpMGKss.RIp--scGC...............LSGSCKS.CP.....EG+s........shcphh................................	0	29	58	82
+8845	PF09013	YopH_N		YopH, N-terminal	Mistry J, Sammut SJ	anon	pdb_1huf	Domain	The N-terminal domain of YopH is a compact structure composed of four alpha-helices and two beta-hairpins. Helices alpha-1 and alpha-3 are parallel to each other and antiparallel to helices alpha-2 and alpha-4. This domain targets YopH for secretion from the bacterium and translocation into eukaryotic cells, and has phosphotyrosyl peptide-binding activity, allowing for recognition of p130Cas and paxillin [1].	19.60	19.60	19.70	135.40	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.50	0.71	-4.45	4	68	2009-09-11 06:44:49	2006-08-04 10:34:58	5	2	31	4	6	18	0	114.70	61	40.01	CHANGED	hpIssLpp.lS.plsp.tsG-phG+L+........sThQtlo.opuhpssEKsFAppVLcHVpNssLspcDlApLL......phsNaEL+pstsGpslLsGLRo-QLoLpDAKlLL-AAhRQ	.hplssLpp.ls.plsQ.tpGspsG+Lp........pT..hhp.upthppuEKsFAppVLpHVtNssLopcDhApLL......plsNhEL+pstsGpsllsuLRo-QhoLpDAKlLLEAAhRQ.	2	0	2	2
+8846	PF09014	Sushi_2		Beta-2-glycoprotein-1 fifth domain	Mistry J, Sammut SJ	anon	pdb_1g4f	Domain	The fifth domain of beta-2-glycoprotein-1 (b2GP-1) is composed of four well-defined anti-parallel beta-strands and two short alpha-helices, as well as a long highly flexible loop. It plays an important role in the binding of b2GP-1 to negatively charged compounds and subsequent capture for binding of anti-b2GP-1 antibodies [1].	22.10	22.10	22.10	23.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.07	0.72	-4.22	6	79	2009-01-15 18:05:59	2006-08-04 10:39:08	5	8	40	7	37	69	0	82.80	44	22.33	CHANGED	RAsCpVPlK+upVlYsGhKhhltDltcshlhHG-+VoFaCKspcK+CSasssupChDGslplPuCacE.s.Ltah...+p.sS-lpsC	.............+AsCplslK+upVlYpGc+lplp-hhcsshhHG-pVoFaCKNK..E.K.+CSYotsupChDGslclPpCFc.E.o.lt.ah...+o.sS-lpsC..............	0	1	6	19
+8847	PF09015	NgoMIV_restric		NgoMIV restriction enzyme	Mistry J, Sammut SJ	anon	pdb_1fiu	Domain	Members of this family are prokaryotic DNA restriction enzymes, exhibiting an alpha/beta structure, with a central region comprising a mixed six-stranded beta-sheet with alpha-helices on each side. A long 'arm' protrudes out of the core of the domain between strands beta2 and beta3 and is mainly involved in the tetramerisation interface of the protein. These restriction enzymes recognise the double-stranded sequence GCCGGC and cleave after G-1 [1].	20.70	20.70	21.20	27.80	19.50	20.40	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.90	0.70	-5.41	6	56	2012-10-11 20:44:44	2006-08-04 10:56:01	5	2	50	6	9	43	3	239.70	54	95.23	CHANGED	FH+pLl.-GslhhsN...........stu..lsSNADuSsspSpslApGltcplpu.polsc+h.....AGQTsGspFEcIsppFlccTFp+lpHLRPGsWpVppssutp+hp.IspaEQYuHLtcLs+lu+cpsELuuuLGsDYsIpPDIVlsRcstsDptIN.csc.LVD..ssssthos.LR+uN....supP..lLHASISCKWTIRSDRAQNTRoEALNLlRNRKGRlPHIVsVTAEPhPSRIuSlALGTGDIDCVYHhALsELppulpulGp-Dst-hLpshIsG+RL+DISDLPLDLul	..................FHtpLl.psslhhhN...........stG..VsSNADuSNppShsIApuIAchLtu.coluc+l.....sGQTuGstFEslsscFlppsF.+LpHlRPG.sWsVppluupsRhc.IucapQYsHLssLscAscpss-LAAALGsDYsIoPDIlVsRp..sDttIN.psphLV..D..-s.lsphus.LRtsN.....ushP...lLHASISCKWTIRSDRAQNARSEuLNLlRNRKGRLPHIVVVTAEPoPSRluSIALGTG-IDCVYHFAL.ELppslpsl..s.......h-DAh.....-hhhhMVsG+RLKDISDLPLDLAV..........................	1	2	7	7
+8848	PF09016	Pas_Saposin		Pas factor saposin fold	Mistry J, Sammut SJ	anon	pdb_2b8i	Domain	Members of this family adopt a compact structure comprising five alpha helices. Charged and polar residues are exposed mostly on the surface, while most of the hydrophobic residues are buried inside the hydrophobic core of the helical bundle. The precise function of this domain is unknown, but it is has been shown to induce secretion of periplasmic proteins, especially collagenase [1].	27.50	27.50	123.30	123.20	27.30	27.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.37	0.72	-3.98	6	38	2009-01-15 18:05:59	2006-08-04 10:57:41	5	1	33	1	8	27	0	75.40	68	99.10	CHANGED	hpoLIY-TLhNLAsp-PEQHApIRQpLYEQLDLsF-KQLALYusVLGPASSGKLtspcslscAV-pAlclLEh.p+	MKTLIY-TLlsLAsQEPEQHApIRQNLYEQLDLPFDKQLALYSsALGPASSGKLEsppuIsNAVDsAl+LLEsPE+.	0	0	1	6
+8849	PF09017	Transglut_prok		Microbial transglutaminase	Mistry J, Sammut SJ	anon	pdb_1iu4	Domain	Microbial transglutaminase (MTG) catalyses an acyl transfer reaction by means of a Cys-Asp diad mechanism, in which the gamma-carboxyamide groups of peptide-bound glutamine residues act as the acyl donors. The MTG molecule forms a single, compact domain belonging to the alpha+beta folding class, containing 11 alpha-helices and 8 beta-strands. The alpha-helices and the beta-strands are concentrated mainly at the amino and carboxyl ends of the polypeptide, respectively. These secondary structures are arranged so that a beta-sheet is surrounded by alpha-helices, which are clustered into three regions [1].	25.00	25.00	722.90	722.60	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.37	0.70	-5.36	4	22	2009-01-15 18:05:59	2006-08-04 11:06:04	5	1	10	5	0	27	0	397.00	82	99.39	CHANGED	MppRRRhLsFATlGAVlCTAGhMPSsupA....AuuGsGEEctSYAETHcLTADDVcsINALNEpA.sAupsG.......PS....FRAPDu...DDRVTPPAEPLDRMPDsYRs.hGRApTVVNNYIRKWQQVYSHRDG+KQQMTEEQREhLSYGCVGVTWVNSG.YPTNRLAFA.FDEsKYKN-LKNuRPRssETRAEFEGRlAK-SFDEuKGFpRAR-VASVMNKALENAHDEusYlsNLKpELANsNDALhpEDuRSsFYSALRNTPSFKERsGGNaDPSKMKAVIYSKHFWSGQDppGSSDKRKYGDP-AFRPspGTGLVDMSRDRNIPRSPspPGEuaVNFDYGWFGAQTEADADKTVWTHGNHYHAPNGuLGsMHVYESKFRNWSsGYuDFDRGAYVITFIPKSWNTAPsKVcQGWP	..................M..RtphLsFAThuAllCsuGhhPSsupA....AssGsGEpctSYAETHtLTA-DVcNINALNcpA.ssupsG.......PS....FRAPDu...DDRVTPPAEPLDRMPDsYRs.hGRApTVVNNYIRKWQQVYSHRDG+KQQMTEEQREhLSYGCVGVTWVNSG.YPTNRLAFAFFDEsKYKN-LKNuRPRssETRAEFEGRlAK-SFDEuKGFpRAR-VASVMNKALENAHDEGsYlDNLKpELANtNDALhpEDuRSsFYSALRNTPSFKERsGGNaDPSKMKAVIYSKHFWSGQDppGSSDKRKYGDP-AFRPDpGTGLVDMS+DRNIPRSPspPGEuaVNFDYGWFGAQTEADADKTlWTHGNHYHAPNGuLGsMHV.YESKFRNWSsGYuDFDRGs.YVITFIPKSWNTAPsKVKQGWP..................	0	0	0	0
+8850	PF09018	Phage_Capsid_P3		P3 major capsid protein	Mistry J, Sammut SJ	anon	pdb_1hqn	Domain	The P3 major capsid protein adopts a 'double-barrel' structure comprising two eight-stranded viral beta-barrels or jelly rolls, each of which contains a 12-residue alpha-helix. This protein then trimerises through a 'trimerisation loop' sequence, and is incorporated within the viral capsid [1].	25.00	25.00	937.50	937.30	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.38	0.70	-5.88	3	7	2009-01-15 18:05:59	2006-08-04 11:10:51	6	1	6	78	0	6	0	394.00	100	99.75	CHANGED	AQVQQLTPAQQAALRNQQAMAANLQARQIVLQQSYPVIQQVETQTFDPANRSVFDVTPANVGIVKGFLVKVTAAIKNNHATEAVALTDFGPANLVQRVIYYDPDNQRHTETSGWHLHFVNTAKQGAPFLSSMVTDSPIKYGDVMNVIDAPATIAAGATGELTMYYWVPLAYSETDLTGAVLANVPQSKQRLKLEFANNNTAFAAVGANPLEAIYQGAGAADCEFEEISYTVYQSYLDQLPVGQNGYILPLIDLSTLYNLENSAQAGLTPNVDFVVQYANLYRYLSTIAVFDNGGSFNAGTDINYLSQRTANFSDTRKLDPKTWAAQTRRRIATDFPKGVYYCDNRDKPIYTLQYGNVGFVVNPKTVNQNARLLMGYEYFTSRTELVNAGTISTT	AQVQQLTPAQQAALRNQQAMAANLQARQIVLQQSYPVIQQVETQTFDPANRSVFDVTPANVGIVKGFLVKVTAAIKNNHATEAVALTDFGPANLVQRVIYYDPDNQRHTETSGWHLHFVNTAKQGAPFLSSMVTDSPIKYGDVMNVIDAPATIAAGATGELTMYYWVPLAYSETDLTGAVLANVPQSKQRLKLEFANNNTAFAAVGANPLEAIYQGAGAADCEFEEISYTVYQSYLDQLPVGQNGYILPLIDLSTLYNLENSAQAGLTPNVDFVVQYANLYRYLSTIAVFDNGGSFNAGTDINYLSQRTANFSDTRKLDPKTWAAQTRRRIATDFPKGVYYCDNRDKPIYTLQYGNVGFVVNPKTVNQNARLLMGYEYFTSRTELVNAGTISTT	0	0	0	0
+8851	PF09019	EcoRII-C		EcoRII C terminal	Mistry J, Sammut SJ	anon	pdb_1na6	Domain	The C-terminal catalytic domain of the Restriction Endonuclease EcoRII has a restriction endonuclease-like fold with a central five-stranded mixed beta-sheet surrounded on both sides by alpha-helices. It cleaves DNA specifically at single 5' CCWGG sites [1].	20.30	20.30	20.30	20.70	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.92	0.71	-4.40	14	145	2012-10-11 20:44:45	2006-08-04 11:12:05	6	2	130	13	25	144	16	164.70	40	44.93	CHANGED	F+hhEctllhp+lptGFs......sVDsFl........sauhSVpNRRKSRAG+SLE.HLcplhpstGl....pasppu...hT.....EssKKPDFLFPusstYc......sstFPscpLpMLusKTTCKDRWRQVLsEA-R..IcpKHLhTLp.G.lSpsQhpEMpcpslpLVVPpsl+poYspp.+scLhTlpsFI	...........................................FhhhEchhh.phlppsas........slDpFl........shupS.l.....sNRRKSRAGKSLEhHLcplF.ctGl....pFpsQA........hT...........Es..sKK...PDFL.FPuutsY+............s.tFs.scpLpMLusKTTCKDRWRQlLsEA......-..R......I..p..phaLhTLp-G.lStsQhpEMpcpslpLVVPp.slpcp..aspthpsplholtsFI.................	0	11	17	22
+8852	PF09020	YopE_N		YopE, N terminal	Mistry J, Sammut SJ	anon	pdb_1l2w	Domain	The N terminal YopE domain targets YopE for secretion from the bacterium and translocation into eukaryotic cells [1].	21.60	21.60	24.20	78.80	20.70	18.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.75	0.71	-4.09	2	31	2009-01-15 18:05:59	2006-08-04 11:19:43	5	1	27	6	2	13	0	104.70	97	52.96	CHANGED	MKISSFISTSLPLPTSVSGSSSVGEMSGRSVSQQpS-QYANNLAGRTESPQGSSLASRIhE+LSShAHSsItFIpRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLsSLDA	..........................MSGRSVSQQpSDQYANNLAGRTESPQGSSLASRIIERLSShAHSVIGFIQRMFSEGSHKPVVTPAPTPAQMPSPTSFSDSIKQLAAETLPKYMQQLNSLDA	0	0	1	1
+8853	PF09021	HutP		HutP	Mistry J, Sammut SJ	anon	pdb_1wmq	Domain	The HutP protein family regulates the expression of Bacillus 'hut' structural genes by an anti-termination complex, which recognises three UAG triplet units, separated by four non-conserved nucleotides on the RNA terminator region. L-histidine and Mg2+ ions are also required. These proteins exhibit the structural elements of alpha/beta proteins, arranged in the order: alpha-alpha-beta-alpha-alpha-beta-beta-beta in the primary structure, and the four antiparallel beta-strands form a beta-sheet in the order beta1-beta2-beta3-beta4, with two alpha-helices each on the front (alpha1 and alpha2) and at the back (alpha3 and alpha4) of the beta-sheet [1].	25.00	25.00	41.80	41.50	24.20	23.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.44	0.71	-3.93	17	271	2009-01-15 18:05:59	2006-08-04 11:30:01	6	2	242	36	67	175	0	131.60	41	90.58	CHANGED	+lu+sAlhhAlopocEEEtplcphh.tppsh+ssssclGGp..h.psspKllcsslsAAK+pGVIpcs.ap-ptAlhtAThEAlptlhspshulss.....GhKluIsR........cs-alAVAlahslGlhhL..-c.slGLGhp	...pluRhAhhlAlupppEppthh.p....htcGh+ssssclGu......sspKlltuh.sAAKpstVIcss.ap-ptAlhtAhhEALhtltp.ttltLss.....Gh+huIsR........puEaluVAlassIGh.hh...-c.uIGLGhp.............	0	30	50	58
+8854	PF09022	Staphostatin_A		Staphostatin A	Mistry J, Sammut SJ	anon	pdb_1oh1	Domain	The staphostatin A polypeptide chain folds into a slightly deformed, eight-stranded beta-barrel, with strands beta-4 through beta-8 forming an antiparallel sheet while the N-terminus forms a a psi-loop motif. Members of this family constitute a class of cysteine protease inhibitors distinct in the fold and the mechanism of action from any known inhibitors of these enzymes [1].	24.10	24.10	24.10	24.10	23.40	23.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.28	0.72	-4.20	3	151	2012-10-01 18:54:33	2006-08-04 11:30:27	5	1	150	1	2	24	0	105.00	74	97.89	CHANGED	McpYpLINIccscscapEKYWLHILEGlWHPp-lsTSPLKITFNKsIsPsYICKhINEDSR+IILsNsDNoNIIIEIIIINc+KIlFNllNKEuLGTSPKITFIK	MEQhELFSIDKF..KCNSEAKYYLNIIEGEWHPQDLNDSPLKFILSTSDDSDYICKYINTEHKQLTLYNKNNSSIVIEIFIPNDNKILLTIMNTEALGTSPRMTFIK...	0	1	1	2
+8855	PF09023	Staphostatin_B		Staphostatin B	Mistry J, Sammut SJ	anon	pdb_1y4h	Domain	Staphostatin B inhibits the cysteine protease Staphopain B, produced by Staphylococcus aureus, by blocking the active site of the enzyme. The domain adopts an eight-stranded mixed beta-barrel structure, with a deviation from the up-down topology of canonical beta-barrels in the amino-terminal part of the molecule [1].	25.00	25.00	30.10	30.00	22.20	19.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.35	0.72	-4.23	2	163	2012-10-01 18:54:33	2006-08-04 11:32:06	5	1	163	8	2	15	0	107.00	97	98.19	CHANGED	MYQLpFIpls.DshpLT+.cQssIpLFIGNW.N.phQKSIsIRpGsDTsHNQYpIL.IDTtHQRIKhoS.-s.plhYILDY-DTpHIhhQTSsKpuhGTSRPIhYE+	...MYQLQFINLVYDTT.KLTHLEQTNINLFIGNWSNHQLQKSICIRH..GD.DTSHNQYHILFIDTAHQRIKFSSIDNEEIIYILDYDDTQHILMQTSSKQGIGTSRPIVYER.	0	1	1	2
+8857	PF09025	YopR_core		YopR Core	Mistry J, Sammut SJ	anon	pdb_1z21	Domain	The YopR core domain, predominantly found in the Yersinia pestis virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR [1].	25.00	25.00	98.30	98.10	22.20	21.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.90	0.71	-4.19	9	74	2009-01-15 18:05:59	2006-08-04 11:50:47	5	1	69	1	9	35	16	140.50	43	81.11	CHANGED	s-ushh....p+hp.sssL-shLus.sPuspRElLW.hap.....pGscpss...ppLhtslppcLlucFuGp.hsl.sshDhsEL+uhlppa.PLGup+EpsLLplhu-LKsh.....PshtaLs-LsRcEL.hLIPhNuMVcNLh+pSHKLDLE	.......................................................s-lhspLEptLpuEssptsRElLW.ta......Ausssst...p.Lhss.lcEcLLuRFuQp.tsl.PshDhsEL+uhLppa.shG+ppEshLLQlLtulKss.....sGh.YLu-Llp+EL.lLlPhNuhVDNLl+NSHKlDh-	0	1	3	4
+8858	PF09026	CENP-B_dimeris	Cenp-B_dimeris;	Centromere protein B dimerisation domain	Mistry J, Sammut SJ	anon	pdb_1ufi	Domain	The centromere protein B (CENP-B) dimerisation domain is composed of two alpha-helices, which are folded into an antiparallel configuration. Dimerisation of CENP-B is mediated by this domain, in which monomers dimerise to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation [1].	24.30	24.30	24.30	24.50	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.46	0.72	-3.77	2	32	2012-10-08 13:44:34	2006-08-04 11:51:16	5	5	24	4	19	37	1	93.70	69	22.07	CHANGED	PTLHFLEGtEDS-SDS-EEE-D--EDE..-DE-D-E-sDEVPVPSFGEAMAYFAMVKRYLTS.PIDDRVQSHILHLEHDLVHVTRKNHARQAGsRGLGHQS	............PTLHFLEGtEDS-SDS-EE--..-E--..D---.-.D-D.D-EDsD.EVPVPSFGEAMAYFAMVKRY..LTSFPIDDR....VQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS..................	0	4	4	7
+8859	PF09027	GTPase_binding		GTPase binding	Mistry J, Sammut SJ	anon	pdb_1cf4	Domain	The GTPase binding domain binds to the G protein Cdc42, inhibiting both its intrinsic and stimulated GTPase activity. The domain is largely unstructured in the absence of Cdc42 [1].	21.30	21.30	22.10	21.30	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.12	0.72	-4.38	5	170	2009-01-15 18:05:59	2006-08-04 11:51:45	5	14	62	1	77	128	0	62.20	49	7.74	CHANGED	AGlSAQDIpVPLKsGFlHoG+GhuNsR+C.WGsPucF-NsYLs..hDP.shhhspLSsA..tPTQHLuslG	......AGlSAQDISpPLpsSFIHT..GHGDu..sP++C.WGhPD+ID-lYLsNPMDPPDlhss..p...usu....tph.stht........................	0	15	22	43
+8860	PF09028	Mac-1		Mac 1	Mistry J, Sammut SJ	anon	pdb_2avw	Domain	The bacterial protein Mac 1 adopts an alpha/beta fold, with 14 beta strands and 9 alpha helices. The N-terminal domain is made up predominantly of alpha helices, whereas the C-terminal domain consists predominantly of beta sheets. Mac 1 blocks polymorphonuclear opsonophagocytosis, inhibits the production of reactive oxygen species and contains IgG endopeptidase activity [1].	20.10	20.10	20.20	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.26	0.70	-5.67	3	78	2009-01-15 18:05:59	2006-08-04 12:34:31	5	9	60	8	13	76	1	280.70	32	54.08	CHANGED	KhsDuIuAPVlApsplhVcMKV.DRGlEs-sapsDsEV....cTSEss.YcVTchcc.................lWs+GlTPPAhFspGGhV.........apAPahAtpGaYDhNKolNG+..DlsLCaAATASNMLHWWFEQNs-YIEpYLKc..cKQKlslGEphclLDlR+YIcohQDQsN...SclFNhFRsh...uausRRsGalsDuLlDhFINGYYLpV.+sGssNLscoY...DpRGGlFsDVFs+sspsKpLTsR..h+scThKEFu-Ll+KsL-sK+ALGLoa..opuNh.hsHlVTlWGA-YDssGNIcAlYITDSD.spAsIGhK+YslGVcuuGNltlsAc+lK........scstGAhlDGLaTLcpGQDpW	.................................................................................................................h......phpp.............................lWscGlss..Pt..p.pst.h..............apA.Pa.ss.......p.GaYDhsKs....hNup......Dp.LChAAsAuNMlHWWh-QNpppl-tYLpc...cptpl..htpp.thh-l+chlsoh....tsQps....SplFphF+s....hhuhpp.GhhsDhllDhFINGYh.ph..ptsss.....lp.....cs....Dp+GGhF.sVF....ppphLTs+..hhtts.hcchup.l+p.LppspslGLoa..phhsh...hsHllslWGA-a..D.sp.GplcA..lYlTDSD..p.......pt.....p.....lGhK+YhlshsssGp..tls.pphp........ppshGu.l.hlaTlphGps.W......................................................	1	7	11	13
+8861	PF09029	Preseq_ALAS		5-aminolevulinate synthase presequence	Mistry J, Sammut SJ	anon	pdb_1h7d	Domain	The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import [1].	20.70	20.70	21.30	22.40	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.79	0.72	-4.05	2	196	2009-01-15 18:05:59	2006-08-04 12:34:46	5	6	50	2	81	167	0	83.20	29	19.56	CHANGED	hlAhAhllRpCPhLupsPpshLt+suKo..hLh.htRCPl............LuTthPThpQ...KsTpsGs-psuhA.S+CPFhhsEhtcRcutlVp+Au.ElpEDVpphps	.....................................hlp.pCPhLspsspshltpshts..hl.hhtpCPh....................................................h..sst......st.....p.p........................tt..t..s..s....sp.pt..........s..hA..spCPFh.u.phtt.tstlh.cAu.ElQEDVpthp...............................................................................	0	7	12	32
+8862	PF09030	Creb_binding		Creb binding	Mistry J, Sammut SJ	anon	pdb_1kbh	Domain	The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery [1].	21.10	21.10	21.60	24.50	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.57	0.72	-3.84	4	148	2009-01-15 18:05:59	2006-08-04 12:48:14	5	14	46	7	70	100	0	105.30	55	4.94	CHANGED	..ssQWsQusLPQ...hpsuhPRPVhp.t.AQtuss...GPR.susQss.....tuI..uPsALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYsAsQPt.	..................................................s.W.t...Qus.lP..Q..Q........h.....sG....M...s.RPs..M.....u.Q..t.u.s..........uP.....p....ss.s...Qs.s....................tuh....u.sALQ-LLRTL+SPSS.PpQQQQVLNIL+SNPQLMAAFI..KQ.RsAKYs.usp.Pt..........	0	11	19	36
+8864	PF09032	Siah-Interact_N		Siah interacting protein, N terminal 	Mistry J, Sammut SJ	anon	pdb_1ysm	Domain	The N terminal domain of Siah interacting protein (SIP) adopts a helical hairpin structure with a hydrophobic core stabilised by a classic knobs-and-holes arrangement of side chains contributed by the two amphipathic helices. Little is known about this domain's function, except that it is crucial for interactions with Siah. It has also been hypothesised that SIP can dimerise through this N terminal domain [1].	21.30	21.30	21.30	21.40	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.83	0.72	-3.92	10	147	2009-01-15 18:05:59	2006-08-04 12:59:19	6	6	107	6	89	136	0	69.90	32	31.30	CHANGED	hsphlcpLptDL-El+pLlEpApRpRVpDlLppEh+KlEsElppppp....QcpQ..ppppEspcPou.hsssspsYTVKI	..........ppLppDL-El+sLLppApRpRV+-hLosEhp+lEsEltpt.h.p......p...tp.......p........................................................	0	23	36	61
+8865	PF09033	DFF-C		DNA Fragmentation factor 45kDa, C terminal domain	Mistry J, Sammut SJ	anon	pdb_1iyr	Domain	The C terminal domain of DNA Fragmentation factor 45kDa (DFF-C) consists of four alpha-helices, which are folded in a helix-packing arrangement, with alpha-2 and alpha-3 packing against a long C-terminal helix (alpha-4). The main function of this domain is the inhibition of DFF40 by binding to its C-terminal catalytic domain through ionic interactions, thereby inhibiting the fragmentation of DNA in the apoptotic process. In addition to blocking the DNase activity of DFF40, the C-terminal region of DFF45 is also important for the DFF40-specific folding chaperone activity, as demonstrated by the ability of DFF45 to refold DFF40 [1].	25.00	25.00	39.80	39.30	23.20	22.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.00	0.71	-4.41	5	60	2009-01-15 18:05:59	2006-08-04 12:59:53	5	2	35	2	30	53	0	163.20	61	53.64	CHANGED	DGGTAWluRES..MEsD-sD.suGsD..+WKNLAcQLKEDLSSIILMSEEDLQsLIDVPsuELAusLshSppKVQuLQsTLQRVLDRREEERQSKQLLELYL+AlEKEGsh..+pQEscAsLu-E.DuVDoGh...sElsScsshuSpILhlLK-KsuPELSLSoQDLEhVsK	............................DGGTAWloQES..h-.s.DEsDouuGl...KWKNlARQ.LK-DLSSIILLSEEDLQsLlDlPCuDLApELsQSssplQsLQpTLQQVLDpREEsRQSKQLLpLYLpALEKEGulLSKppES...cA..u.hu.-EhDAVDo.Gh..spEsuSclsLsSplLssLKEKsAPELSLSSQDLElVs..........	0	2	4	11
+8866	PF09034	TRADD_N		TRADD, N-terminal domain	Mistry J, Sammut SJ	anon	pdb_1f3v	Domain	The N terminal domain of 'Tumour necrosis factor receptor type 1 associated death domain protein' (TRADD) folds into an alpha-beta sandwich with a four-stranded beta sheet and six alpha helices, each forming one layer of the structure. The domain allows docking of TRADD onto 'tumour necrosis factor receptor-associated factor' (TRAF): the binding is at the beta-sandwich domain, away from the coiled-coil domain. Binding ensures the recruitment of cIAPs to the signaling complex, which may be important for direct caspase-8 inhibition and the immediate suppression of apoptosis at the apical point of the cascade [1].	25.00	25.00	96.60	95.50	20.00	18.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.55	0.72	-4.07	6	45	2009-01-15 18:05:59	2006-08-04 13:05:06	5	2	37	2	25	42	0	110.40	57	37.13	CHANGED	-Su.Guh-uhEILKlHcuDP.LhVpLKFsuhssCpRFLpuYtpGALppuLpp+hsphLAl..cuLtlpTpLKAGscpLDthLsD.EpCLpaIptpQP-RLRD-ElAELEppLps	...-Su.GS.-slphLKIHcSDPQLIVQLRFCGcpsCsRFLcuYREGALRsuLQppLusuLA...pul.sLpLEL+AGAEcLDshLsDEERCLpsIhtppPDRLRDEEluELE-tL+s...........	0	1	3	10
+8867	PF09035	Tn916-Xis		Excisionase from transposon Tn916	Mistry J, Sammut SJ	anon	pdb_1y6u	Domain	The phage-encoded excisionase protein Tn916-Xis adopts a winged-helix structure that consists of a three-stranded anti-parallel beta-sheet that packs against a helix-turn-helix (HTH) motif and a third C-terminal alpha-helix. It is encoded for by Tn916, which also codes for the integrase Tn916-Int. The protein interacts with DNA by the insertion of helix alpha-2 into the major groove and the contact of the hairpin that connects strands beta-2 and beta-3 with the adjacent phosphodiester backbone and/or minor groove. Tn916-Xis stimulates phage excision and inhibits viral integration by stabilising distorted DNA structures [1].	22.90	22.90	22.90	22.90	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.25	0.72	-3.88	8	457	2012-10-04 14:01:12	2006-08-04 13:11:25	5	1	293	1	23	251	24	66.20	52	93.39	CHANGED	MN+.-..VPIWEKhoLTIEEAAcYasIGpNKLRpLs.cNPsscFVLalGo+hhIKRKcFEcaI-shssl	.................MppsD..lPIWE+YTLTIEEASKYFRIGENKLR+LAE..E..Nc..sAsW...l..IhNGN..RIQIKRKQFEK.hIDsLcsI.............	0	13	18	19
+8868	PF09036	Bcr-Abl_Oligo		Bcr-Abl oncoprotein oligomerisation domain	Mistry J, Sammut SJ	anon	pdb_1k1f	Domain	The Bcr-Abl oncoprotein oligomerisation domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerisation domain is essential for the oncogenicity of the Bcr-Abl protein [1].	20.90	20.90	21.10	32.00	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.81	0.72	-4.02	4	67	2009-09-11 10:35:23	2006-08-04 13:43:33	5	10	25	8	23	63	0	72.20	81	8.04	CHANGED	hVpPluFAEAW+AQFP-..u-PPhM-LRShGD........lEQEL-+C+uSIRRLEpEVN+ERFRMIYLQTLLAKERKSYD+QRWGF+R	..MV-PVGFsEAW+AQFPD..SEPP+MELR..SVGD........IEQELERCKASIRRLEQEVNpERFRMIYLQTLLAKEKKSYDRQRWGFRR.......	1	2	5	15
+8869	PF09037	Sulphotransf		Stf0 sulphotransferase	Mistry J, Sammut SJ	anon	pdb_1tex	Domain	Members of this family are essential for the biosynthesis of sulpholipid-1 in prokaryotes. They adopt a structure that belongs to the sulphotransferase superfamily, consisting of a single domain with a core four-stranded parallel beta-sheet flanked by alpha-helices [1].	20.70	20.70	20.70	20.70	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.47	0.70	-4.88	13	172	2012-10-05 12:31:09	2006-08-04 13:59:44	5	5	158	4	52	155	31	228.40	33	80.83	CHANGED	uYllCuosRSGSTLLsclLpuTGsAGpPppFFp........pss.hppWhtths.........shp.t.s-hthscsahptslptG+ussGVaGh+LMhpphshlhppLspL.PshsuDshR..lccsaG.p.shalHLpRcDpVuQAVShhRApQotlW+..ttsDusc.tR................tspYDssuIsphlphLccpEpuWpsWFtppsl-PlcIsY-sLsssPptslsslLptLGl-sphAsthsPslp+.ADppSc-WscRYRpD	.................................................................................................YllhuotRSGSTLLsc.LpuTG....ss....GpPpEaFp........................ssp..ccWhtthp................shp...s.ps-ht..s.s.tah.ptlh..stG.p.osNGlaGs.KL....Mh.sQhshl.p+.h...t..tl.ss...hs.........s..cshc..hlc.cl.h.G..p.tshhlHlpR.DlVsQAVShh......RA...hQ.......T.plW+.......sp.s.....Dspccsp....................shYcs......s.....sIu+hlp.tLcs.p-psWc.sWFs.p.cs.Ic.P...lcl.sY.s.L...h.c..s....s...s..h..lusVL-tlG...-..s..p.h..A.s..........tP...hlc+Qu...sppocEWspRa+t-................................................................................	0	10	31	42
+8870	PF09038	53-BP1_Tudor		Tumour suppressor p53-binding protein-1 Tudor	Mistry J, Sammut SJ	anon	pdb_1xni	Domain	Members of this family consist of ten beta-strands and a carboxy-terminal alpha-helix. The amino-terminal five beta-strands and the C-terminal five beta-strands adopt folds that are identical to each other. This domain is essential for the recruitment of proteins to double stranded breaks in DNA, which is mediated by interaction with methylated Lys 79 of histone H3 [1].	20.50	20.50	20.80	21.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.49	0.71	-4.29	3	89	2012-10-02 16:56:36	2006-08-04 14:11:33	5	3	51	16	40	84	2	117.20	74	7.46	CHANGED	GSSFVGLRVVAKWSSNGYFYSGKIT+DAGuGKYKLLFDDGYECDVLGKDILLCDPIPLDTEVTALSEDEYFSAGVVKGHKKESpELYYSIEKDGQRKWYKRMAVILSLEQGNRLREQYGLGP	......GsSFVGLRVVAKWS.SNGYFYSGKITR.D.VGAGKYKLLFDDGYEC.....DVLGKDILLC...DPIPL.DT..E..V...TA.L.S.ED...EYFSAGV...V.KG..HR.K.E..S..GELYYS.IE.KE.GQRK.W..YKRMAVILSLEQGNRLREQYGLGP......................	0	7	9	23
+8871	PF09039	HTH_Tnp_Mu_2	Mu_I-gamma;	Mu DNA binding, I gamma subdomain	Mistry J, Sammut SJ	anon	pdb_2ezh	Domain	Members of this family are responsible for binding the DNA attachment sites at each end of the Mu genome. They adopt a secondary structure comprising a four helix bundle tightly packed around a hydrophobic core consisting of aliphatic and aromatic amino acid residues. Helices 1 and 2 are oriented antiparallel to each other. Helix 3 crosses helices 1 and 2 at angles of 60 and 120 degrees, respectively. Excluding the C-terminal helix 4, the fold of the I-gamma subdomain is remarkably similar to that of the homeodomain family of helix-turn-helix DNA-binding proteins, although their amino acid sequences are completely unrelated [1].	20.50	20.50	20.50	20.50	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.27	0.72	-4.32	6	131	2012-10-04 14:01:12	2006-08-04 14:14:54	6	14	112	4	25	141	1	106.80	35	17.57	CHANGED	hapVpshscsDWhPhLlst....sttcppsphu.Is-cAWtaFpuDYLR.EKPohssCYcRLcpAAp-pGW.sIPShuohpR+h.pplPcsplVhsREGpauLp+LhPsQpRo	.................................pVpthscsDWhssLlst....tss+ps.s+h..u.chsp-AW.p.F.hpuD.YLR.E...+Ps..aspCYcRLc...ts..Accp..G..W...s.....IPShpohpRRl..pplscs...h...hVhtRE.G-cALhc.hhPuQpRo...........	0	9	18	22
+8872	PF09040	H-K_ATPase_N		Gastric H+/K+-ATPase, N terminal domain	Mistry J, Sammut SJ	anon	pdb_1iwc	Domain	Members of this family adopt an alpha-helical conformation under hydrophobic conditions. The domain contains tyrosine residues, phosphorylation of which regulates the function of the ATPase. Additionally, the domain also interacts with various structural proteins, including the spectrin-binding domain of ankyrin III [1].	25.00	25.00	46.20	45.50	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.61	0.72	-8.12	0.72	-3.85	5	35	2009-01-15 18:05:59	2006-08-04 14:31:05	6	6	21	2	19	36	0	41.00	88	4.36	CHANGED	GKAENYELYSVELGPGPGGDMAAKMS.KKKAGGGGGKKKEKL	..GKAENYELYSVELG.PGPGGDMAAKMS.KKK.AGGGGGK+KEKL......	0	1	1	2
+8873	PF09041	Aurora-A_bind		Aurora-A binding 	Mistry J, Sammut SJ	anon	pdb_1ol5	Domain	The Aurora-A binding domain binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an alpha-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1 [1].	20.20	20.20	21.60	23.00	19.50	17.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.46	0.72	-4.21	6	51	2009-01-15 18:05:59	2006-08-04 14:31:21	5	3	31	3	24	49	0	63.60	57	8.93	CHANGED	MSpspsoYSaDAPosFINFSSLc--.DhcNhDSWFDcpANLENh.sspctluclhQspsshpKstLQp	......MSQspoSYSaDAPocFINFoSLc-EtDspNlDSWFEEKANLENKh.ucNGhutlaQuKTsLRKsslpp.................	0	2	3	7
+8874	PF09042	Titin_Z		Titin Z	Mistry J, Sammut SJ	anon	pdb_1h8b	Domain	The titin Z domain, that recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly [1].	21.50	21.50	28.40	21.50	19.80	21.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.92	0.72	-4.36	13	282	2009-01-15 18:05:59	2006-08-04 14:33:34	6	47	33	1	104	290	0	41.60	41	1.23	CHANGED	pEplR+Es...........EK.sAVspVVlAssKA+ppEslscspEphus+pEQ	..............pEpl+KEs..........................................................-K.sAVspVVlAssK.A+cpE.h.+spEthss+p-Q..............	0	6	7	19
+8875	PF09043	Lys-AminoMut_A		D-Lysine 5,6-aminomutase alpha subunit	Mistry J, Sammut SJ	anon	pdb_1xrs	Domain	Members of his family are involved in the 1,2 rearrangement of the terminal amino group of DL-lysine and of L-beta-lysine, using adenosylcobalamin (AdoCbl) and pyridoxal-5'-phosphate as cofactors. The structure is predominantly a PLP-binding TIM barrel domain, with several additional alpha-helices and beta-strands at the N and C termini. These helices and strands form an intertwined accessory clamp structure that wraps around the sides of the TIM barrel and extends up toward the Ado ligand of the Cbl cofactor, providing most of the interactions observed between the protein and the Ado ligand of the Cbl, suggesting that its role is mainly in stabilising AdoCbl in the precatalytic resting state [1].	25.00	25.00	70.20	70.10	17.50	17.30	hmmbuild  -o /dev/null HMM SEED	509	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.65	0.70	-6.38	8	226	2009-01-15 18:05:59	2006-08-04 14:41:35	6	3	199	25	54	150	6	435.60	50	68.49	CHANGED	LsLDhshV-+ARstA+cIAtssQcFI-pHTTVoVERTlsRLLGIDGVDspsVPLPNlVVDHlK-pssLspGAAhaluNAMlpTGpoPQEIAEuVAsGELDLpphPhp-ptcI+tshpslAptsV-+I+uNR+pRE-hlcph.G-tssPaLYVIVATGNIYEDVVQApAAARQGADVIAVIRoTuQSLLDYVPaGATTEGFGGTYATQENFRIMR+ALDEVGpElGRYIRLCNYCSGLCMPEIAAMGALERLDhMLNDALYGILFRDINMpRTLlDQaFSRlINGaAGIIINTGEDNYLTTADAhEcAHTVLASQhINEQFALhAGLP-EQMGLGHAFEM-P-LENGFLaELAQApMsREIFPKAPLKYMPPTKaMTGNIFKGHlQDAhFNlVolhTsQpIHLLGMLTEAIHTPFhpDRhLuIENAKYIFNNh+clusEIpFKcGGhIppRApEVLcKAhsLLEpIEpcGLFpuIE+GhFGsV+RPhDGGKGLsGVlpKstsYaNPFl-LM	.................................................................................................................................................................................cYhcph.ss.p.s.sPhlhs....lAoGch.-DlcphRhAAhpGADhIhVIRTTGQShlDhl.EG.TsEGhGGs.hTpcphRh.RKAhD.lp-.EVGR.IphpsYsSGlshPElAlhhA.EGlsshhpDs.YslLaRsINhhRoaVDtt.u+plhAhAsIh..sGtcNh.sTA.c.t.h.csh.p.l....hVpchlNphaulhsGhPc-.IGLups.....sPss.sphhh-LsaAlhlR-LFs-h.h+h..sT+YhpuslhcuhhpcslssLlohLTutcIQ.shhPsEuhssPWhpspshulposK.sasuhcGlt-.lphpc-G.lschsR-lh-+AlshLpE.h..cs.s.G.......hFsAlEcGhFsD...........IsRstpGGhu.usVsERDsDYhsPsh-..th....	0	31	42	52
+8876	PF09044	Kp4		Kp4	Mistry J, Sammut SJ	anon	pdb_1kpt	Domain	Members of this fungal family of toxins specifically inhibit voltage-gated calcium channels in mammalian cells. They adopt an alpha/beta-sandwich structure, comprising a five-stranded antiparallel beta-sheet with two antiparallel alpha-helices lying at approximately 45 degrees to these strands [1].	25.00	25.00	26.30	26.20	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.86	0.71	-4.32	2	55	2009-01-15 18:05:59	2006-08-04 15:01:32	5	2	26	2	49	54	0	118.20	34	83.92	CHANGED	.hLhhshh.ssstpLGINCRGSupC..hhsst.hh.hhRs.puhss.sphassGE+hApVs.....ssssuhsAalQs.sssshushcuhtHh..lspHGC+VCGSsP.....usNsVscGpLThNYV.Nu	........................................h.h....hshh.h.ss..suALGINCRGSuhC..s...s....u.....s.....ss....t...h..hphhttl.pshss...s+passGpcIACss..........s....t..su.......lCAF...hQsh.s.u.s...sssshpu..ltph..............Lh-HGCptCGSlP...stssNsVspGpLThNhV...s.......	0	7	24	37
+8877	PF09045	L27_2		L27_2	Mistry J, Sammut SJ	anon	pdb_1y76	Domain	The L27_2 domain is a protein-protein interaction domain capable of organising scaffold proteins into supramolecular assemblies by formation of heteromeric L27_2 domain complexes. L27_2 domain-mediated protein assemblies have been shown to play essential roles in cellular processes including asymmetric cell division, establishment and maintenance of cell polarity, and clustering of receptors and ion channels. Members of this family form specific heterotetrameric complexes, in which each domain contains three alpha-helices. The two N-terminal helices of each L27_2 domain pack together to form a tight, four-helix bundle in the heterodimer, whilst the third helix of each L27_2 domain forms another four-helix bundle that assembles the two units of the heterodimer into a tetramer [1].	20.90	20.90	21.00	21.40	20.00	18.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.67	0.72	-4.43	3	113	2009-01-15 18:05:59	2006-08-04 15:14:15	5	14	40	6	50	114	0	57.80	61	3.30	CHANGED	DKpRALQAlERLQuKLKERGDVssEEKLSLL+SVLQSPLFsQILoLQpSlQQLKDQVN	....DKppsLQshERLQsKL+ERGDsupp-KLSlL+ssLQSPLFsQILoLQpSlpQLKcQls......	0	6	9	22
+8878	PF09046	AvrPtoB-E3_ubiq		AvrPtoB E3 ubiquitin ligase	Mistry J, Sammut SJ	anon	pdb_2fd4	Domain	The E3 ubiquitin ligase domain found in the bacterial protein AvrPtoB inhibits immunity-associated programmed cell death (PCD) when translocated into plant cells, probably by recruiting E2 enzymes and transferring ubiquitin molecules to cellular proteins involved in regulation of PCD and targeting them for degradation. The structure of this domain reveals a globular fold centred on a four-stranded beta-sheet that packs against two helices on one face and has three very extended loops connecting the elements of secondary structure, with remarkable homology to the RING-finger and U-box families of proteins involved in ubiquitin ligase complexes in eukaryotes [1].	25.00	25.00	107.80	107.10	24.60	18.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.58	0.71	-4.12	4	25	2009-01-15 18:05:59	2006-08-04 15:14:50	5	1	22	1	2	34	0	122.10	75	30.16	CHANGED	.tVVADIRAALc.IusQFsQLRTISKADAESp-.GF+DAAD.HPDDsTpCLFGEELSLSNPcQQVIGLAGpsTDhsQPYSQEuNKsLsFMDMKKLAQaLAuKPEHPMsR-pLsAcNIAKYAFRIVP	..............tVVsDI...RAALD.IusQFSQLRTISKADAESEELGF+DAAD.HP.DsATpCLFGEELSLSNPDQQVIGLAsNPTDpsQPYSQEsNKsLsFMDMKKLAQaLAsKPEHPhNRQpLDAcNIAKYAF+IVP	0	0	0	1
+8879	PF09047	MEF2_binding		MEF2 binding	Mistry J, Sammut SJ	anon	pdb_1n6j	Domain	The myocyte enhancer factor-2 (MEF2) binding domain, predominantly found in the calcineurin-binding protein CABIN 1, adopts an amphipathic alpha-helical structure, which allows it to bind a hydrophobic groove on the MEF2S domain, forming a triple-helical interaction. Interaction of this domain with MEF2 causes repression of transcription [1].	21.50	21.50	21.90	34.60	21.30	19.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.30	0.72	-4.31	2	61	2009-01-15 18:05:59	2006-08-04 15:27:42	5	3	32	1	25	48	0	34.20	90	2.02	CHANGED	TLLSPKGSISEETKQKLKssILSuQSAAss+K-oL	...TLLSPKGSISEETKQKLK......SAILSAQSAANVRKESL....	0	2	5	12
+8880	PF09048	Cro		Cro	Mistry J, Sammut SJ	anon	pdb_1d1m	Domain	Members of this family are involved in the repression of transcription by binding as a homodimer to palindromic DNA operator sites in phage lambda: they repress genes expressed in early phage development and are necessary for the late stage of lytic growth. These proteins have a secondary structure consisting of three alpha-helices and three beta-sheets, and dimerise through interactions between the two antiparallel beta-strands [1].	30.80	30.80	30.80	36.10	29.10	30.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.74	0.72	-4.33	5	146	2012-10-04 14:01:12	2006-08-04 15:37:13	5	1	126	17	5	68	1	59.00	66	89.33	CHANGED	Mp..RITLuDYVt+aGQAKAA+DLGVtQuAISKAL+AGRcIhVolssDGSVhAEEVRPFPS	....Mc.RITLpDYAhRFG.QsKTAKDLGVhQSAIsKAI+AGRcIFLTlpuDG.S.VhAEEV+PFPS......	0	0	1	4
+8881	PF09049	SNN_transmemb		Stannin transmembrane	Mistry J, Sammut SJ	anon	pdb_1zza	Domain	Members of this family consist of a single highly hydrophobic transmembrane helix that transverses the lipid bilayer at a 20 degree angle with respect to the membrane normal. They contain a conserved cysteine residue (Cys32) that, together with Cys34 found in the stannin unstructured linker domain, constitutes the putative trimethyltin-binding site that resides at the end of the transmembrane domain close to the lipid/solvent interface [1].	25.00	25.00	49.90	49.40	20.50	19.60	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.58	0.72	-4.25	3	39	2009-01-15 18:05:59	2006-08-04 15:42:51	5	2	37	1	24	25	0	33.00	95	37.68	CHANGED	MSIMDHSPTTGVVTVIVILIAIAALGALILGCW	.MSIMDHSPTTGVVTVIVILIAIAALGALILGCW	0	1	3	8
+8882	PF09050	SNN_linker		Stannin unstructured linker	Mistry J, Sammut SJ	anon	pdb_1zza	Domain	Members of this family are unstructured, acting as connectors of the stannin helical domains. They contain a conserved CXC metal-binding motif and a putative 14-3-3-zeta binding domain. Upon coordinating dimethytin, considerable structural or dynamic changes in the flexible loop region of SNN may take place, recruiting other binding partners such as 14-3-3-zeta, and thereby initiating the apoptotic cascade [1].	25.00	25.00	63.90	63.40	17.80	16.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.51	0.72	-6.97	0.72	-4.39	3	39	2009-01-15 18:05:59	2006-08-04 15:43:56	5	2	37	1	24	25	0	26.00	95	29.68	CHANGED	CYLRLQRISQSEDEESIVGEGETKEP	CYLRLQRISQSEDEESIVGDGETKEP	0	1	3	8
+8883	PF09051	SNN_cytoplasm		Stannin cytoplasmic	Mistry J, Sammut SJ	anon	pdb_1zza	Domain	Members of this family consist of a distorted cytoplasmic helix that is partially absorbed into the plane of the lipid bilayer with a tilt angle of approximately 80 degrees from the membrane normal. They interact with the surface of the lipid bilayer, and contribute to the initiation of the apoptotic cascade on binding of the unstructured linker domain to dimethyltin [1].	25.00	25.00	34.70	39.20	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.42	0.72	-6.91	0.72	-4.21	5	37	2009-01-15 18:05:59	2006-08-04 15:44:50	5	1	35	1	24	23	0	26.50	87	30.25	CHANGED	LLVQYSAKGP+VE+KTKL.TPNGTESH	LLVQYSAKGPCVERKAKL.TPNGPEVH....	0	1	3	8
+8884	PF09052	SipA		Salmonella invasion protein A	Mistry J, Sammut SJ	anon	pdb_2fm8	Domain	Salmonella invasion protein A is an actin-binding protein that contributes to host cytoskeletal rearrangements by stimulating actin polymerisation and counteracting F-actin destabilising proteins. Members of this family possess an all-helical fold consisting of eight alpha-helices arranged so that six long, amphipathic helices form a compact fold that surrounds a final, predominantly hydrophobic helix in the middle of the molecule [1].	25.00	25.00	50.80	50.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	674	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-13.09	0.70	-6.13	3	143	2009-01-15 18:05:59	2006-08-04 15:52:32	5	2	130	10	3	112	0	584.70	80	99.48	CHANGED	MlTussTQAPshLsussosouTpASsLuupLSDVR.SuoToLusctSlu-LESFsAsasQ+SLDsLFuuSs+ADsL+ElYoNSsNsYAKpEIhEFAsVapSLl+QsuLsPEAcKsLpKluAQYoApIIKDGLuEKSAFGPWos+TKKtaQLRpNLE++LA-IAppHTuGEApKLGscLlpsEVooFItSCIEscLGpoLDslTSppLTcLVDuAAtpAFEuLRppRpcLI-p+GFSVG+LARDL-TVAVlPpLLRsVLssI..sPuD+tP-psuhssPscPpPuuGPsPuGsGKsucPstIHYHIN..IcssN+ShDNR+asNpucoalssup...RHlDNSsH-NScpsAsssTotosD.LsRNGpSlLSssuSssutpHuLVsuVTp...........slsHSISGpVDssAssoA.E+VhNsou-ucDGtVhhutlGSDGLTTS.pEhsAlsS+ScsG+PLpuss+uVsD...........sL+PlhothsGsEsVKouTssSsDTstSGschpp.sAGpssssNSsTDusGsFoGl+FRsGshYhTlPTls.h+uht..F-AccclLsulRsALEPsuopPhsQRREF-uLRs-ILPSDTh+psslKs+soDuschscLs-.cA-TL+cslssHPthEK....L+ElApsLuREAsLo+lccsos.LLoslLD..GLpuDs-hRAuPs...hsuKPsssuVlpTlDGLH	................MQTEIKTQATNLAANLSAVRESATsTLSGEIKGPQLEDFPALIKQASLDALFKCGKDAEALKEVFTNSNNVAGKKAIMEFAGLFRSALNATSDSPEAKTLLMKVGAEYTAQIIKDGLKEKSAFGPWLPETKKAEAKLENLEKQLLDIIKNNTGGELSKLSTNLVMQEVMPYIASCIEHNFGCTLDPLTRSNLTpLlDtA.AAKAVcALDMCHQKLTQEQGTSVGREARHLEMQTLIPLLLRNVFAQI...PADKLPD......PKIPEPAAGPVPDG.GKKAEPTGINININ..IDSSNHSVDNSKHINNSRSHVDNSQ...RHIDNSNHDpSRKTIDNSRTFIDN.SQRpGESHHSTNSSNVSHSHSRVDSTTHQTETAHSASTGAIDHGIAGKIDlTAHATA.EAVTNASSESKDGKVVTSEKGTTGETTSFDEVDGVTSKSIIGKPVQATVHGVDDNKQQSQTAEIVNVKPLASQLAGVENVKhDTLQSDoTVITGNK.....AGTTDNDNSQTDKTGPFSGLKFKQNSFLSTVPSVTNMHSMH..FsAREsFLGVIRKALEPDTSTPFPVRRAFDGLRAEILPNDTIKSAALKAQCS....DIDKHPELKA.KM-TLKEVITHHPQKEK....LAEIALQFAREAGLTR.KGETDYVLSNVLD..GLIGDGSWRAGPAYESYLNKPGVDRVITTVDGLH.....	0	1	1	2
+8885	PF09053	CagZ		CagZ	Mistry J, Sammut SJ	anon	pdb_1s2x	Domain	CagZ is a 23 kDa protein consisting of a single compact L-shaped domain, composed of seven alpha-helices that run antiparallel to each other. 70% of the residues are in alpha-helix conformation and no beta-sheet is present. CagZ is essential for the translocation of the pathogenic protein CagA into host cells [1].	25.00	25.00	134.40	134.30	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.42	0.71	-4.99	3	75	2009-01-15 18:05:59	2006-08-04 16:00:15	5	1	40	1	1	58	0	195.10	97	99.99	CHANGED	MELGFNETERQKILDSN+SLMGNANEVRDKFIQNYATSLKDSNDPQDFLRRVQELRINMQKNFISFDsYYNYLNNLVLASYNRCKQEKTFAESTIKNELTLGEFVAEISDNFNNFMCDEVARISDLVASYLPREYLPPFIDGNMMGVAFQILGIDDFGRKLNEIVQDIGTKYIILSKNKTYLTSLERAKLITQLKLNLE	MELGFNEAERQKILDSN+SLMGNANEVRDKFIQNYAoSLKDSNDPQDFLRRVQELRINMQKNFISFDAYYNYLNNLVLASYNRCKQEKTFAESTIKNELTLGEFVAEISDNFNNFMCDEVARISDLVASYLPREYLPPFIDGNMMGVAFQILGIDDFGRKLNEIVQDIGTKYIILSKNKTYLTSLERAKLITQLKLNLE.....	0	1	1	1
+8887	PF09055	Sod_Ni		Nickel-containing superoxide dismutase	Mistry J, Sammut SJ	anon	pdb_1t6i	Domain	Nickel containing superoxide dismutase (NiSOD) is a metalloenzyme containing a hexameric assembly of right-handed 4-helix bundles of up-down-up-down topology with an N-terminal His-Cys-X-X-Pro-Cys-Gly-X-Tyr motif that chelates the active site Ni ions. NiSOD catalyses the disproportionation of superoxide to peroxide and molecular oxygen through alternate oxidation and reduction of Ni, protecting cells from the toxic products of aerobic metabolism [1].	25.00	25.00	49.20	49.10	19.70	18.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.85	0.71	-3.76	25	144	2009-09-10 20:18:48	2006-08-04 16:03:13	6	4	139	81	73	148	532	126.20	43	79.80	CHANGED	ssspVpA.......HCDlPCGlYDPusARltu......olhphhcclp-lsst..........st.tsphsRhlshKEp+ApclKcclhllWoDYFKss+l-..........pYPcLH-lhapshhtuuts..KtslDhspApcLlstlsclschFWpoK	.............s.spVpA.......HCDlPCGVYDPApARIcAE.....oVcuhpcKhpu.css..............shhsRhlhIKEp+AchsK+cl.lLWoDYFKssHhE.............cYPcLHpLhpcshKhsuAu....KsssDsupupcLLshIscIscIFWcTK................................	0	32	54	68
+8888	PF09056	Phospholip_A2_3		Prokaryotic phospholipase A2	Mistry J, Sammut SJ	anon	pdb_1faz	Domain	The prokaryotic phospholipase A2 domain is predominantly found in bacterial and fungal phospholipases, as well as various hypothetical and putative proteins. It enables the liberation of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. The domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [1].	26.10	26.10	26.10	26.50	26.00	25.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.86	0.72	-3.86	18	148	2009-01-15 18:05:59	2006-08-04 16:06:21	6	9	113	5	85	147	14	106.50	36	37.65	CHANGED	TDphlFuhslssFsssRssp..sPup.L..DWooDGCSpuP.......DsPhGF...sFtsuCpRHDFGYRNY+tQsRFo.ss+t+..IDssFhpDhhptC...sthssh...htssCctsApsYYpAVRtFG	..................................t.shsta.stRpsp...sst..h..sWooDsCSsu..P..........Dp....PhGa....sF...tsuCpRHDFG.......Y....RNa....+.....t.....t...s+....F....ot....ss+.p+..lDssFppDLhphC..........st.st.............tpssCcu.hAtsYYtAV+thG..........................	0	22	50	73
+8889	PF09057	Smac_DIABLO		Second Mitochondria-derived Activator of Caspases	Mistry J, Sammut SJ	anon	pdb_1g73	Domain	Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution [1].	25.00	25.00	29.90	27.90	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.43	0.70	-5.24	4	112	2009-01-15 18:05:59	2006-08-04 16:07:38	5	3	52	23	36	107	0	189.70	51	94.57	CHANGED	p+L.tuss.lL+aptslls..sus.+pRplphL.ssaRK.sloluVGsulCAVPhsQ+sE..sLSpEuLlRRAsSLVTDSusTFLSQTThALl-ulTpYsKAVaTLlSLp+pYpu.luKhsspEEsuIWQVIIGtRsEhps++cphh+aESsWMsAVsLSEhAAEAAYpoGADQAslss+splQlsQoQVEpl+plu+cAEhpLA-opsEElcRhhp............p.ulp-tE-lPEAYLRED	..........................................................................................................t....hpp.hh.hshsh.slCAlPht.Q....p.-..sLSp-uLhRRAsSLVTDSooTFLSQTThALI-AlTEYoKAVYTLlSLh+pYtuhLGKhsupEEDpVWQVIIGtRsEhos+ppEhh+hEooWhoAV.sLSEhAAEAAYpoGADQASlTs+splQlspsQVpcs+pLStcAEpKLAEspspEl..cphtp...............p...t..ttp.t-t..EAYLRED.............................	0	5	9	19
+8890	PF09058	L27_1		L27_1	Mistry J, Sammut SJ	anon	pdb_1rso	Domain	The L27 domain is a protein interaction module that exists in a large family of scaffold proteins, functioning as an organisation centre of large protein assemblies required for the establishment and maintenance of cell polarity. L27 domains form specific heterotetrameric complexes, in which each domain contains three alpha-helices [1].	21.60	21.60	21.60	23.00	20.60	21.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.99	0.72	-4.09	4	147	2009-01-15 18:05:59	2006-08-04 16:10:09	5	21	76	3	67	170	0	59.10	57	8.95	CHANGED	MPV++pDspRALpLLE-YpS+LSpstDctLRouIERVIsIFpSsLFQALlDIQEFYElTLhD.ss	.......MPl++p.-spRALcLLE-Y+u+Lo.p.............spD+pLRpuIERVIsIFpSsLFQAL.l..DIQ..EFYElTLLDs.............	1	24	30	48
+8891	PF09059	TyeA		TyeA	Mistry J, Sammut SJ	anon	pdb_1xl3	Domain	Members of this family are composed of two pairs of parallel alpha-helices, and interact with the bacterial protein YopN via hydrophobic residues located on the helices. Association of TyeA with the C terminus of YopN is accompanied by conformational changes in both polypeptides that create order out of disorder: the resulting structure then serves as an impediment to type III secretion of YopN [1].	21.10	21.10	21.40	21.50	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.67	0.72	-4.05	7	103	2009-01-15 18:05:59	2006-08-04 16:28:52	5	2	94	2	16	55	1	84.90	45	49.81	CHANGED	MAYssS-LMuDlIALVEcRWsusp-lpplssAhpLsssppplpFapEL++LlRhlPl-VFuDEEQRQNLlpAsQtALDtAI-pEEEE	.......MAYt.S-LMuDllALl-cRWlusp-lppLusuhsL..ssscpclpFap-L++lhRhlPlpVFuD-EQRQNLLpusQpAlD.AI-pEEEp....	0	7	9	11
+8892	PF09060	L27_N		L27_N	Mistry J, Sammut SJ	anon	pdb_1vf6	Domain	The L27_N domain plays a role in the biogenesis of tight junctions and in the establishment of cell polarity in epithelial cells. Each L27_N domain consists of three alpha-helices, the first two of which form an antiparallel coiled-coil. Two L27 domains come together to form a four-helical bundle with the antiparallel coiled-coils formed by the first two helices. The third helix of each domain forms another coiled-coil packing at one end of the four-helix bundle, creating a large hydrophobic interface: the hydrophobic interactions are the major force that drives heterodimer formation [1].	25.00	25.00	26.20	25.20	23.80	16.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.30	0.72	-4.16	4	63	2009-01-15 18:05:59	2006-08-04 16:39:47	5	6	39	8	31	52	0	48.90	65	7.50	CHANGED	ElE-LL.SLKplp+sLsDsQSQpDlELlhQLlppsDFQsAapIHNAVAt	...ElEDLhSSLKHIQHTLVDSQSQEDIuLLLQLVQNpDFQNAFKIHNAVo.s	0	2	5	13
+8894	PF09062	Endonuc_subdom		PI-PfuI Endonuclease subdomain	Sammut SJ	anon	pdb_1dq3	Domain	The endonuclease subdomain, found in the prokaryotic protein ribonucleotide reductase, assumes an alpha-beta-beta-alpha-beta-beta-alpha-alpha topology. The four stranded beta-sheet forms a saddle-shaped surface and assembles together through an interface made of alpha-helices. The presence of 14 basic residues on the surface of the beta-sheets suggests that this large groove may be involved in DNA binding [1].	24.40	24.40	24.70	38.40	23.20	24.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.50	0.72	-3.24	3	5	2012-10-03 01:41:40	2006-08-07 09:45:50	5	3	5	1	3	5	0	87.00	66	4.99	CHANGED	PDGEDYEFIFDYWLAGFIAGDGslDKY+SHVKGHEYlYDRLRIYDYphEThtIINDaLEKTFG++YSlQ+DRNIaYIDIKARsITSHYlELL-GI-NG	PDGEDYEFIFDYWLAGFIAGDGsFDKY+SHVKGHEYIYDRLRIYDYRlETFEIINDYLEKTFG++YSlQ+DRNIYYIDIKARsITSHYlKLL-GIDNG.......	0	1	1	2
+8895	PF09063	Phage_coat		Phage PP7 coat protein	Sammut SJ	anon	pdb_1dwn	Domain	Members of this family form the capsid of P. aeruginosa phage PP7. They adopt a secondary structure consisting of a six stranded beta sheet and an alpha helix [1].	25.00	25.00	25.30	283.20	24.00	17.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.78	0.71	-4.34	2	2	2009-01-15 18:05:59	2006-08-07 10:03:32	5	1	1	17	0	4	0	127.00	96	99.61	CHANGED	SKTIVLSVGEATRTLTEIQSTADRQIFEEKVGPLVGRLRLTASLRQNGAKTAYRVNLKLDQADVVDCSTSVCGELPKVRYTQVWSHDVTIVANSTEASRKSLYDLTKSLVspupsEDLVVNLVPLGR	SKTIVLSVGEATRTLTEIQSTADRQIFEEKVGPLVGRLRLTASLRQNGAKTAYRVNLKLDQADVVDCSTSVCGELPKVRYTQVWSHDVTIVANSTEASRKSLYDLTKSLVspupsEDLVVNLVPLGR	0	0	0	0
+8896	PF09064	Tme5_EGF_like		Thrombomodulin like fifth domain, EGF-like	Sammut SJ	anon	pdb_1dx5	Domain	Members of this family adopt a fold similar to other EGF domains, with a flat major and a twisted minor beta sheet. Disulphide pairing, however, is not of the usual 1-3, 2-4, 5-6 type; rather 1-2, 3-4, 5-6 pairing is found. Its extended major sheet (strands beta-2 and beta-3 and the connecting loop) projects into thrombin's active site groove. This domain is required for interaction of thrombomodulin with  thrombin, and subsequent activation of protein-C [1].	21.40	21.40	21.70	22.20	21.30	20.40	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-7.98	0.72	-4.34	6	46	2012-10-03 09:47:55	2006-08-07 11:18:30	5	20	34	0	27	41	0	34.80	55	7.17	CHANGED	MFCNQTsCPADCDPNosu..sChCPEGYILD-Gs...lC	..MFCNpTsCPA.DCDPNs.s...sCpCPEGYILD-G....hC........	1	1	4	11
+8897	PF09065	Haemadin		Haemadin	Sammut SJ	anon	pdb_1e0f	Domain	Members of this family adopt a secondary structure consisting of five short beta-strands (beta1-beta5), which are arranged in two antiparallel distorted sheets formed by strands beta1-beta4-beta5 and beta2-beta3 facing each other. This beta-sandwich is stabilised by six enclosed cysteines arranged in a [1-2, 3-5, 4-6] disulphide pairing resulting in a disulphide-rich hydrophobic core that is largely inaccessible to bulk solvent. The close proximity of disulfide bonds [3-5] and [4-6] organises haemadin into four distinct loops. The N-terminal segment of this domain binds to the active site of thrombin, inhibiting it [1].	25.00	25.00	26.00	71.90	23.30	15.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.30	0.72	-4.36	2	2	2009-01-15 18:05:59	2006-08-07 11:44:31	5	1	1	3	0	3	0	27.00	100	46.55	CHANGED	CDCGEKICLYGQSCNDGQCSGDPKPSS	CDCGEKICLYGQSCNDGQCSGDPKPSS	0	0	0	0
+8898	PF09066	B2-adapt-app_C		Beta2-adaptin appendage, C-terminal sub-domain	Sammut SJ	anon	pdb_1e42	Domain	Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [1].	21.10	21.10	21.40	21.10	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.29	0.71	-4.20	31	409	2009-01-15 18:05:59	2006-08-07 12:37:55	5	12	142	8	246	427	5	109.50	33	13.65	CHANGED	hs.D...uplspppF.phWpsl.spss..-hphphp...thss.pshpptLpspslahlApppsss...phhaaos+tssshhhlhElthpssssphplslKspss..chsthhhphhcpllp	..........................hsE-...Gph..-+phFltTW+...sl.Psps.......Ehpaphp.......s.hs..s....-.slps+L.pssNlaTIA+Rssps...pchhY....ShKh...s...s...Gl.hhLsELplp.s...us.s.s...h....p.....lolKscss.....Essphhhpsh-sll.....................................................	0	86	125	180
+8899	PF09067	EpoR_lig-bind		Erythropoietin receptor, ligand binding	Sammut SJ	anon	pdb_1eer	Domain	Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions [1].	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.61	0.72	-4.03	12	520	2012-10-03 16:25:20	2006-08-07 13:34:30	5	16	109	41	149	538	0	98.30	31	19.36	CHANGED	Spsu..hhstcsc.hpCFopshcDFTCFW-tspssshs...YshhYphps.-phppCslhppssssu...h.hChFsps.-splaV.hclpV.spssttspasR.lsV-	...........ss.......stcPchhpChS.phETFoCaWpsG...s..p..ss..l...s..os...apLhY...........p......p....c......s......p............p............h+E.C.P..-Ypsuus......so.......CaFspp..pTolWhsYplpVtsssphss..pc...................................	0	7	22	58
+8900	PF09068	EF-hand_2	efhand_1; EF_hand_2;	EF hand	Sammut SJ	anon	pdb_1eg3	Domain	Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (Pfam:PF00397), enhancing dystroglycan binding [1].	21.10	21.10	21.10	21.60	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.71	0.71	-4.06	30	673	2012-10-02 16:17:27	2006-08-07 14:46:03	6	51	101	2	277	608	0	121.10	42	11.54	CHANGED	chs-LhpsL..tDLNslRaSuYRTAhKLRtlQKthp.........LcLlsltslhcsFccpsLpp...............Dps.....lsVsclhssLoslY...................................................ppLspchsshs.sls............................................................................................................................hslDhhLNaLLNVYDssRsG+IpVLShKhulssLC	......................hppLatph....tcLsslR..hSsYRTAhKLRhlQKths..................................LcLlsl.ss.hEuhccpsLpp.......................Dps.....lsVsc.l.ssLoolY....................................................pLppchsshh.pls............................................................................................................................hslshhLNaLLssYD..........o..t..psG+lpVhShKsuLhoLC................................................................................................................	0	64	87	168
+8901	PF09069	EF-hand_3	efhand_2;	EF-hand	Sammut SJ	anon	pdb_1eg3	Domain	Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (Pfam:PF00397), enhancing dystroglycan binding [1].	21.70	21.70	21.70	28.00	20.20	21.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.96	0.72	-3.91	30	641	2012-10-02 16:17:27	2006-08-07 14:54:41	6	48	99	2	269	581	0	90.00	48	8.40	CHANGED	Lp-KaRYlFpQl.......u-ssGhhDpp+LulhL+-slplP+plGEssuFGsp..lEsSVRSCFpts....t.......................csclph.....spFL-WhphE..PQolVWLPlLHRlA	...........l.DKhRY.lFppl.......usosGhhspp+Ls.hL+-slplPptlhEssoFGh.....hEsSVRSCFpt........................................p.cIph.....stFLDhhhh-...P...Qs.h.......V.WLPlLHRlA...................................	0	59	79	159
+8902	PF09070	PFU		PFU (PLAA family ubiquitin binding)	Mistry J	anon	Pfam-B_5813 (release 20.0)	Domain	This domain is found N terminal to Pfam:PF08324 and binds to ubiquitin [1].	20.90	20.90	21.10	22.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.71	0.71	-4.08	39	348	2009-01-15 18:05:59	2006-08-07 15:24:39	6	21	290	7	246	358	3	111.50	39	15.52	CHANGED	ppsGp+EGpshhl+ss..GslEAYpWo..pupW.KIG-VVs..u....suss......stKthacG+cYDYVFDVDlp-GtPsLKLPYNhs-NPatsAp+Flp+p-..Ls.sYh-QVspFIhpN..TpGssls	................................................t.psGp+-GQsphl..+ps..splpAapWo......ptpW.plGsVVs..u..........sstp........utKhhapGc-YDYV..FsVDlp...-....G..tP...slKLPYNh...u-sPatsApcFlpcNc..Ls.s.......YlDQVspFIhpNTpu.t..s............	0	91	141	207
+8903	PF09071	Alpha-amyl_C		Alpha-amylase, C terminal	Sammut SJ	anon	pdb_1eh9	Domain	Members of this family, which are found in the prokaryotic protein glycosyltrehalose trehalohydrolase, assume a gamma-crystallin-type fold with a five-stranded anti-parallel beta-sheet that packs against the C-terminal side of a beta-alpha barrel. This domain is common to family 13 glycosidases and typically contains a five to ten strand beta-sheet, however its precise fold varies [1].	20.80	20.80	22.40	59.80	19.80	17.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.95	0.72	-4.22	5	18	2009-01-15 18:05:59	2006-08-07 15:32:08	5	3	18	8	4	16	0	66.80	58	12.17	CHANGED	CcR+lEVcsG-NWLTlptcKlhslauFScSVIplKYoGsLLlSS.sSFP++IscuK.h+l-KGFGlYK	.CNRKLoVENGNaWLTVKGNGYLlVYVFSpSlIEMKYRGTLVLSSNNSFPSQIsEsK.Y+L-KGFALYK.	1	1	1	3
+8904	PF09072	TMA7		Translation machinery associated TMA7	Mistry J, Wood V	anon	manual	Family	TMA7 plays a role in protein translation. Deletions of the TMA7 gene results in altered protein synthesis rates [1].	18.80	18.80	20.80	20.70	18.70	17.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.03	0.72	-3.51	24	302	2009-01-15 18:05:59	2006-08-07 15:37:21	5	6	232	0	204	302	0	61.00	54	81.09	CHANGED	uuRpGGKtKPLKAPKKppp-hDE-DlAFKpKQ+--pKAhKthtsKAtttGPLssu..GIKKSGKK	.............puRpGGKtK.PLKtPKKppK.E.h........DE-Dh...AFKpKQK--pKAhcEhtsKA.t.tKGPLs.sG..GIKKS.GKK...............	0	57	97	157
+8905	PF09073	BUD22		BUD22	Mistry J, Wood V	anon	manual	Family	BUD22 has been shown in yeast to be a nuclear protein involved in bud-site selection.  It plays a role in positioning the proximal bud pole signal [1]. More recently it has been shown to be involved in ribosome biogenesis [2,3].	37.00	37.00	37.00	37.00	36.60	36.40	hmmbuild  -o /dev/null HMM SEED	432	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-12.79	0.70	-5.41	26	209	2009-01-15 18:05:59	2006-08-07 16:03:09	5	4	184	0	156	214	2	308.60	23	71.15	CHANGED	Khcpuhpp...LppsLKpApth-hpKLh++.+th.tt.......................ssshscltcplphh+ph...shpphscthlhppLhK........................s.thh.stthhp...hhp..cKsttspssc.htp...t.t..sslsupLhssK.l+shhsslhpslctlhGhpsptttppcptpsppsppspppp............................ttppppppttcup-ssspcpstc-.....................ssss-tcpps-p...............thspaDsh.....lssusp-pp...........................................t.scspspscscppspcsSpp.tss.s.ppt..sspKKtKtpp...........tpph.LPpL.hsGYaSGu-s-spp.t............-hsspth..............pRKNRhGQ+ARptlWEKKYGppApHlpc.....cpE+ptpcppt.........Rptta-t..Rputp.......................tucsss.ttspspthts+.ppstpstppp.................LHPSWpAK+tAc-pt.t..sApFpGKKlsFD	..............................................................................................................................................................................h......h..........................................................................h.t.h.t.....h...h..h...h......t.......t....tt.tt.....................................................................t.............t......................................t................................tt..................sttptt...................................................................................p...tt.......t...................t..........................p...c.............................................lPpL....suahpsspst..t..........t.t................................cKNRhGQpARptlhEpKaGttApHltp........t...t...t.................................pp.thc...+psth......................................................tttttt.tt..ppttthttp..t.tt.s.ttttp.p......t................LHPSWcAp++tKEpt.p.......s...sFp..G....KKIsFD................................................	0	41	78	126
+8906	PF09074	Mer2		Mer2	Mistry J, Wood V	anon	manual	Family	Mer2 (Rec107) forms part of a complex  that is required for meiotic double strand DNA break formation.  Mer2 increases in abundance and is phosphorylated during the prophase phase of cell division [1]. Blocking double strand break formation results in delayed dephosphorylation and dissociation of Mer2 from the chromosome [1].	27.70	27.50	27.70	27.90	27.40	27.10	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.38	0.71	-4.37	6	18	2009-12-23 15:34:04	2006-08-07 16:30:48	5	1	18	0	11	19	0	183.10	29	57.19	CHANGED	us.shuopssscshputcs.........slsEuD+QIlEWAGKLELESl-L+E.pu-pLhsllsppsppLhhsstplsphL.ppp.....tuppcslcslh.slusplsNpLp-shpulppphcshpt..pp.htt...............h.sspchs+hsu.pshcIIpp.-.stt.ch.Kuhcshp-hlhNhusQLEshptlhlSlS+pL+s....LpsRpsshc	...................................o.sssshpph.s.........slpEuDKQILEWAGKLELESh-LRE.poscLlplLpcNScpLhpshpphsphL.p.c.....tupptslcphhcsLssplpspLccs.psh.spscphps..ppthtp................l.hspclp+hss....+Ih+php.s+Qpch.KShcsTQchlaNlssQLEchpcVLlShS+-hcs....LpsRQssLc..........................................................................................	0	1	7	11
+8907	PF09075	STb_secrete		Heat-stable enterotoxin B, secretory	Sammut SJ	anon	pdb_1ehs	Domain	Members of this family assume a helical secondary structure, with two alpha helices forming a disulphide crosslinked alpha-helical hairpin. The disulphide bonds are crucial for the toxic activity of the protein, and are required for maintenance of the tertiary structure, and subsequent interaction with the particulate form of guanylate cyclase, increasing cyclic GMP levels within the host intestinal epithelial cells [1].	25.00	25.00	128.80	128.50	18.70	17.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.40	0.72	-4.11	2	6	2009-01-15 18:05:59	2006-08-08 09:28:43	5	1	3	1	0	5	0	48.00	98	71.46	CHANGED	STQSNKKDLCEpYRQIAKESCKhGFLGVRDGTAGACFGAQIMVAAKGC	STQSNKKDLCEHYRQIAKESCKKGFLGVRDGTAGACFGAQIMVAAKGC	0	0	0	0
+8908	PF09076	Crystall_2	Sklp_toxin;	Beta/Gamma crystallin	Sammut SJ, Eberhardt R	anon	pdb_1f53	Domain	Members of this family assume a beta-gamma-crystallin fold [1,2], wherein nine beta-strands are connected by loop, and are separated into two sheets, each sheet forming the Greek key motif. The two Greek key motifs face each other in the global topology. The three-dimensional structure of the molecule is a 'sandwich'-shaped beta-barrel structure: hydrophobic side-chains are packed in the large interface area of the beta-sheets. In Streptomyces killer toxin-like protein domain confers a cytocidal effect to the toxin, causing cell death in both budding and fission yeasts, and morphological changes in yeasts and filamentous fungi [1].  This family also includes chitin-biding antifungal proteins [2-3].	25.00	25.00	25.30	45.10	22.60	20.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.35	0.72	-4.21	10	18	2012-10-01 23:14:22	2006-08-08 10:32:47	5	1	15	2	5	22	0	71.90	35	65.99	CHANGED	cIcsHtssspuh.CaANuGshshuh.s......Vs+ISTGNNhVsaphssGs.lpht+hpslTa.NhsshVssh-lh	.......plhoHhssppSh.CaANtGphsFuhhs......VD+ISTGNNhlpapsssGsp..lphs..+apslTaPN+PstVssIcIh........	0	1	5	5
+8909	PF09077	Phage-MuB_C		Mu B transposition protein, C terminal 	Sammut SJ	anon	pdb_1f6v	Domain	The C terminal domain of the B transposition protein from Bacteriophage Mu comprises four alpha-helices arranged in a loosely packed bundle, where helix alpha1 runs parallel to alpha3, and anti-parallel to helices alpha2 and alpha4. The domain allows for non-specific binding of Mu to double-stranded DNA, allowing for integration into the bacterial genome, and mediates dimerisation of the protein [1].	25.00	25.00	26.70	26.70	22.70	20.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.49	0.72	-4.31	15	110	2009-01-15 18:05:59	2006-08-08 10:54:26	6	3	100	1	15	94	1	77.00	46	25.15	CHANGED	SRlAK+suIpKoKKuDVpAlApAWsl..ps-cthplhppIupK.PGuLRlLo+TLRLAuMsAcGcs.s.ls.chlptAap-L	.SRlA+pptlpKsKKuDVpAIAcAWsl..ss-pEhplhppIupK..PGALRlLo+TL+LAshsApGcGts.lspcalptAa+El....	0	4	9	14
+8910	PF09078	CheY-binding		CheY binding	Sammut SJ	anon	pdb_1ffg	Domain	Members of this family adopt a secondary structure consisting of an open-face beta/alpha sandwich, with four antiparallel beta-strands and two alpha-helices. They bind to a corresponding domain on CheY, with subsequent phosphorylation of the CheY Asp57 residue, and activation of CheY, which then affects flagellar rotation [1].	21.10	21.10	21.30	30.50	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.87	0.72	-3.96	30	622	2009-01-15 18:05:59	2006-08-08 13:08:00	6	8	596	13	79	360	5	64.90	65	9.76	CHANGED	LRIpLoplcsp-h-LLpEELGNLGslsssp+uu-oLsshLsoslupDDIsAVhCFVI-s-QIshp	...RIlLSRLKAsEVDLLEEELGpLsTLTDVVKGADSLSAhLsGslAEDDIsAVLCFVIEADQIsFE..........	0	6	28	52
+8911	PF09079	Cdc6_C		CDC6, C terminal 	Sammut SJ	anon	pdb_1fnn	Domain	The C terminal domain of CDC6 assumes a winged helix fold, with a five alpha-helical bundle (alpha15-alpha19) structure, backed on one side by three beta strands (beta6-beta8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate Cdc6 activity [1].	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.61	0.72	-4.26	83	705	2009-01-15 18:05:59	2006-08-08 13:37:42	6	7	285	10	384	699	139	80.40	22	15.43	CHANGED	LhAllhhtppsp...p.hssuclachYpplscp.hsh..cslop.cclpshls-LchhGllpsch.spG..p.tG+ppcl..pLshs..pplhcs.....l	........................Lhullhhhcppt.....cphshsc....lachYppl.Ccp..hsh..pslsp.pchhshl.scLc.thGll.phpp......ptpuphpcl....pLp.hs...cplhtsl........................	0	83	216	312
+8912	PF09080	K-cyclin_vir_C		K cyclin, C terminal	Sammut SJ	anon	pdb_1g3n	Domain	Members of this family adopt a secondary structure consisting of a five alpha-helix cyclin fold. Interaction with cyclin dependent kinases (CDKs) at a PSTAIRE sequence motif within the catalytic cleft of CDK results in the regulation of CDK activity [1].	25.30	25.30	25.70	134.40	24.10	25.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.45	0.72	-3.84	2	10	2009-01-15 18:05:59	2006-08-08 14:06:09	5	1	6	2	0	9	0	103.90	69	40.57	CHANGED	AVLsTDshu.hLhK.hhspppL.hhHppVsp.lpKAlVsPtTGuLPsSlluAA.CALhs.usshP.ss.......pLAphlGsssusLtAAsEplhTolp-FD..RI	AVLATDVTSFLLLKLLGGSQHLDFWHHEVNTLITKALVDPKTGSLPASIISAAGCALLVPANVIPQDTHSGGVVPQLASILGCDVSVLQAAVEQILTSVSDFDL.RI...	0	0	0	0
+8913	PF09081	DUF1921		Domain of unknown function (DUF1921)	Sammut SJ	anon	pdb_1gcy	Domain	This domain, which is found in a set of prokaryotic amylases, has no known function [1].	25.00	25.00	29.30	89.70	24.80	17.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.29	0.72	-4.00	5	11	2009-09-11 11:07:02	2006-08-08 14:32:33	5	2	11	9	3	20	0	50.80	71	9.46	CHANGED	oGFSGLVATlSGSsQpLVhALDSNLSSPuQVASGSFSpAlNpDNGplRIWR	SGYSGLVATVoGSQQTLVVALNSNLSNPGQVASGSFSEAVNsSNGQVRVWR	0	1	2	3
+8914	PF09082	DUF1922		Domain of unknown function (DUF1922)	Sammut SJ	anon	pdb_1gh9	Domain	Members of this family consist of a beta-sheet region followed by an alpha-helix and an unstructured C-terminus. The beta-sheet region contains a CXCX...XCXC sequence with Cys residues located in two proximal loops and pointing towards each other. This precise function of this set of bacterial proteins is, as yet, unknown [1].	20.70	20.70	21.80	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.39	0.72	-3.91	3	19	2009-01-15 18:05:59	2006-08-08 14:42:03	5	1	19	1	16	17	1	66.50	36	78.59	CHANGED	YlIFRCDCGRVLYSKEGsKTRKCVCGKTlNVKcRRIFK+A-opEEASEsVQcMQEEIYGuocF+sAS..E	..............YhIFRC.c.CGRhlYu+-sspT++C.sCG+sl+lKppRIht+scstcEAuphVp+lQpphhGtstFpps..t.......	0	2	13	14
+8915	PF09083	DUF1923		Domain of unknown function (DUF1923)	Sammut SJ	anon	pdb_1gjw	Domain	Members of this family are found in maltosyltransferases, and adopt a secondary structure consisting of eight antiparallel beta-strands, which form an open-sided 'jelly roll' Greek key beta-barrel. Their exact function is, as yet, unknown [1].	19.20	19.20	20.20	98.00	18.30	19.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.15	0.72	-4.49	2	7	2009-01-15 18:05:59	2006-08-08 15:55:14	5	1	6	2	1	5	0	64.10	86	10.04	CHANGED	GKFENLTTKDLVMYSYEKNGQKIVIAANVGKEPKEITGGRVWNGKWSDEEKVVLKPLEFALVVQ	GKFENLTTcDLVMYSYE+NGQKIllAANVGKEPKEITGGRVWNGK.WSDEEKVVLKPL-FsLVVQ	0	1	1	1
+8916	PF09084	NMT1		NMT1/THI5 like	Mistry J, Wood V	anon	Pfam-B_2797 (release 20.0)	Family	This family contains the NMT1 and THI5 proteins.  These proteins are proposed to be required for the biosynthesis of the pyrimidine moiety of thiamine [1][2][3].  They are regulated by thiamine [2].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.17	0.70	-4.75	60	7206	2012-10-03 15:33:52	2006-08-08 16:24:59	6	87	2898	13	2338	13311	2793	196.00	17	56.48	CHANGED	NssHsslalAppKGaFc-pGL-V.cIhps.sssssssphVusGpsDh.ulsht.plh..hs+u.pGhPlhslusllppshsulhshccss.Ip..s.pDLcGK+lG..hss.ssh..pcshlpshlppsGh..s.sclphlss.shsh...ulhsGplDsshhshtsh-hlp..hc..........hcGh...chphhhhp-hGss.sahshlllsscshlpp.ps-hl+pFlcAsp+GhpashscPc-A	................................................................................................................................................................t.......t.....t.......u.......l.....p.....l...p.h..h..........ss....s....s......t.........h.....p.....h..l.....t..s.G..p..hD.....h.....u..........h.........s.......t......t.....................s....h..h.........hs.........t.........s.......p............G.........h.........s..........l..........h.........h........l................u.........s...............h........h.......t.......p.........s...........s.........t........s...........l........l.........s......h............p............s..........s.......s...Ip..............oh.....t...........D..........L.........+.........G.........K.........+....l..u............h..st....uss.............s.p...h......h....h...t.......t.....h........L....p.......p...t...G.l.....................s.....s......c.......l.....p.....h........l..........t.........h.............s............s............s............s.......t................h.................s......u.......l..t...s......G..p..l...D..A..h...h........h.........s............h......h..t.......................................................t.s.........h........h...h.................t.....p..............s.........................................................h......h.....h....s....p....t.p....h....hp.....p...p..............t.......h...t...t...h...h.t..sh....pu.h.t..h...t...................................................................................................................................	0	641	1405	1915
+8917	PF09085	Adhes-Ig_like		Adhesion molecule, immunoglobulin-like	Sammut SJ	anon	pdb_1gsm	Domain	Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues [1].	25.00	25.00	26.30	65.10	18.50	17.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.35	0.72	-4.21	5	43	2012-10-03 02:52:13	2006-08-08 16:37:59	5	4	21	2	9	34	0	108.90	71	32.38	CHANGED	AFPDQLTVSPEALVPGpDpEVACTAHNVTPAcP-uLShSLLLG-QELEGuQALsPEVpE...EPQEuE.DPLFQVTpRWLLPuLGTPuPPALHCQVTMpLPGLpLSHR+uIPVL	.AFPDQLTVSPsALVPG.D.EVACTAHcVTPsDPNuLSFSLLLGsQELEGAQAL.sPEVcE...E..PQp-E.Ds.LFRVTcRWRLPPLGTPsPPALaCQATMRLPGLELSHRQAIPh......	0	1	1	2
+8918	PF09086	DUF1924		Domain of unknown function (DUF1924)	Sammut SJ	anon	pdb_1gu2	Domain	This domain is found in a set of bacterial proteins, including Cytochrome c-type protein. It is functionally uncharacterised.	21.00	21.00	21.00	21.00	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.42	0.72	-3.94	17	99	2012-10-03 10:02:11	2006-08-08 16:50:24	6	2	90	17	41	102	18	95.10	45	66.68	CHANGED	hpssuh.sshsusRGptLappct......cphuCsSCHssssppsGpHspTGK.IpPhAPusNPcRaoDsAKVEKWFpRNCppVlGRtCTspEKGDhlsaL	........h.tstuhsshsAtRGpthatscp.....s.cphSCuoCHssss.....TpsGpHspTGKsIcPhAPusNPcRaTDsAKlEKWFpRNCssVluR-CTstEKuDhLsaL............................	0	9	27	32
+8919	PF09087	Cyc-maltodext_N		Cyclomaltodextrinase, N-terminal	Sammut SJ	anon	pdb_1h3g	Domain	Members of this family assume a beta-sandwich structure composed of the eight antiparallel beta-strands. A ten residue linker is also present at the C-terminal end, which connects the N terminal domain to a distal domain in the protein. This domain participates in oligomerisation of the protein, wherein the N-terminal domain of one subunit contacts the active centre of the other subunit, and is also required for binding of cyclodextrin to substrate [1].	25.00	25.00	29.60	28.80	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.01	0.72	-4.06	28	194	2009-01-15 18:05:59	2006-08-09 09:13:25	6	4	178	12	55	197	92	87.20	39	14.09	CHANGED	+lEPs.WWsGMpNscLQLMlaGcsIus....hplslsh.sGVplpslp+.s-NPNYLFlsL-ls.pAcsGshslshpps............cpphphsYpLKpRcp	....+l-Ps.WWsGM+NP.pLQLhlY..G..csIus....spVolsh.sGVplpsls+.h-sPNYLhlhLsls..pApPGphslshp.ps............cpphshsYpLKtRp............	0	22	42	52
+8920	PF09088	MIF4G_like		MIF4G like	Sammut SJ	anon	pdb_1h6k	Domain	Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices [1].	19.80	19.80	20.10	20.10	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.23	0.71	-4.86	9	328	2012-10-11 20:01:01	2006-08-09 09:53:49	6	9	258	11	235	329	0	159.30	35	20.77	CHANGED	PsssolsuhlhR-hlhDhIshhcaNRp-sA+hLlsLchahs.tTFs..sss.spL...........hsPspSoWplEDlhVEslhuplFpLPsP.hp.lYYpSlLhEhC+huPsslAPslGRulRhlYpplso..hDhEhhcRFlDWFSaHLSNFsFpWpWpEWlsDl.pLssh..HP+hsFl+plIcKElRLSahpRI+poLP-	.......................................................................................................................................................................s.tsph.h-.hhVEslFuplFpL.........PsP.......a....h.......laYtolLlElC.......Kh.......t..P....u.....u...ls..s....lupAhchLYpp.l-s...............hsh..ph.hpRalsWFSaHLSNFpFp......W...p.Wp-Wsssl......p.h.st..................pP+htFlppllcKplRL.Sat.p.RIpphlP...................	0	75	123	197
+8921	PF09089	gp12-short_mid		Phage short tail fibre protein gp12, middle domain	Sammut SJ	anon	pdb_1h6w	Domain	Members of this family adopt a right-handed triple-stranded beta-helix fold, and are found in the middle of the phage short tail fibre protein gp12 [1].	25.00	25.00	25.50	26.00	21.90	18.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.92	0.72	-4.03	2	20	2009-01-15 18:05:59	2006-08-09 11:06:17	5	2	18	1	0	24	0	76.70	59	14.83	CHANGED	TGtTLNGRGuTsSMRGVVKLTTpAGststGDuSuALAWNADVIppRGGQhI.GoLpl.DphT.ANGhhshsGhh+.sst.l	....TGtTLNGRGuTTSMRGVVKLTTTAG.tstGDuSoALAWNADVIsTRGGQTINGoLNl.ssLT.ANGhhshsGhhp.sst.l............	0	0	0	0
+8922	PF09090	MIF4G_like_2		MIF4G like	Sammut SJ	anon	pdb_1h6k	Domain	Members of this family are involved in mediating U snRNA export from the nucleus. They adopt a highly helical structure, wherein the polypeptide chain forms a right-handed solenoid. At the tertiary level, the domain is composed of a superhelical arrangement of successive antiparallel pairs of helices [1].	21.00	21.00	22.80	21.40	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.58	0.70	-5.15	17	319	2012-10-11 20:01:01	2006-08-09 11:16:47	6	8	264	11	230	316	4	252.90	22	31.81	CHANGED	Fpa......pp-shPhpptuppllshh+p+.ts..sc-lhpllppltp.sss.t.....s..hhtlslhlpsllplGS+ShSHshshlp+hpppL+tl........................hpspppcthllculhcaWpspsQhhhlllDphlphpllsstullsWhh.spph....sphhscshsaEhlppslpchttpht....t................................................c-.sst..............................h.ppLtpthsctppllthhhpphl.ll............sp....psspphtphstpW...ahthhGhlcshltca	........................................................apa........tppshPh..tshupplhshl+pK.ss....scEl.sllp...pl..p.spstt.................s...hplclhlpslLplGSKShSHshu.slp+..a+phlpp..l......................................................spsp..ps.php...llpslhchWp.spsQhhhlllDKh.lphpIlsstuVlpWl...F...ssph...............spths.......chalaEhlpsolpKhsp+lhpltpch...p...........................................................................................p-.s.t...........................................phpthpcpLppt.s.-tpslhhhhh..p.phl.lh...................spt...hpspt.th.pph.tp.W........ah.hhth.pthhh..................................................................................	0	79	126	191
+8924	PF09092	Lyase_N		Lyase, N terminal	Sammut SJ	anon	pdb_1hn0	Domain	Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a jelly-roll fold topology consisting of a two-layered bent beta-sheet sandwich with one short alpha-helix. The convex beta sheet is composed of five antiparallel strands, whilst the concave beta-sheet contains five antiparallel beta-strands with a loop between two consecutive strands folding back onto the concave surface. This domain is required for binding of the protein to long glycosaminoglycan chains [1].	26.00	26.00	26.30	30.20	25.60	25.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.22	0.71	-4.64	8	133	2012-10-03 19:46:52	2006-08-09 13:18:47	6	3	88	3	22	127	1	177.80	36	17.68	CHANGED	uhhpSphh-Fs.GsQlP-hhpsuuGSpLSLSus+YhhGpQSLcWcWpsGSohslc+PlsL.pccsASKsaGhpu...lohWIYNEpPVDshhph-LGpch.hsSGsPcAuFcl+lNFoGWRushVShppD..h-Gcch-G.....................Kush-SlRhhAPhtAPpGplaIDRVhhuhc.DARhQhoD.QV...+sR	....................................h.hsh.Ep..p.lPsthpsustSpLolSsp+YKpGppSLcWsa.p.sGus.Ls.lccs.lph...pc.........s...ss.uKshuhpu..............hphWIY.NEpP.c.ct.l.p.F-Fhcs.......Gcss...suFphplNFoGWRusaVsacpD..MpG..ptt-G.......................pMsplRlhAP.......ss.pGp..lalD+lhhuhc.DsRhQhuD.Ql.h......................	0	8	19	19
+8925	PF09093	Lyase_catalyt		Lyase, catalytic	Sammut SJ	anon	pdb_1hn0	Domain	Members of this family are predominantly found in chondroitin ABC lyase I, and adopt a helical structure, with fifteen alpha-helices which are at least two turns long and several short helical turns. The bulk of the domain is formed by ten alpha-helices forming five hairpin-like pairs and arranged into an incomplete toroid, the (alpha/alpha)5 fold. Additionally, two long and two short alpha-helices at the N terminus of the domain wrap around the toroid. At the C-terminal end of the toroid there is one additional short alpha-helix. This domain is required for degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucoronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups [1].	22.80	22.80	23.60	23.00	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.11	0.70	-5.56	4	140	2009-01-15 18:05:59	2006-08-09 13:19:05	6	4	89	3	25	131	2	351.20	36	35.10	CHANGED	P-lpl...loP.psRphcslttl-p..hhp-hls.hhts.t.ps.shpppIsph+pca-thsIshpusG.thoGsPlhss+pp.hapsEhh.s.sKshhssh.lh.ttYss..................+pp.KppaLshaDahhDQGaAhGSuhsThHHaGYpsRthYhusaLM+DsLpEps+hsphhsTLRWas.shppoh.scPstsst.hDpapThhht+lh.lLhhsDs.c+lphlpohSRWlstuL.pssPGhtGulKsDGsuFHHcGsY.PuYuhsuhcsAuphIYLhpcTsFuloEpuppslKcshluhp.YsN.hchuhulSGRHPhss..uppls.uYAhhAluucss.....hD+phAusYLRLhcpssops.tt..a	.................................................................phth....s.lss.ptt-hthh-p..hhpshl......ts..t...t.h..pphpphctpasthpIphp..sG.ploGpsIh...ts.+pp....haps...hhsshscphho...ph.shhssYtsLh.pluhhapps.s.....+pphtchalhhhcalhDQGashGSuhsshHH.aGYss.RthYhuhaLM+c.hLc...cps....hh..pts.csLhW..Ys.shppphp...p.....s....s..s..pupslDhaNThhpt+l.uslhhhs..Ds.....s..c+lphL+uFucWlshul.pssPGhhGGhKsDGosFHHpssY.PuYuhsuhss.AuphlYhLsGTs..Ftlo-pA+pslKpAhLs.....h.....c......h.YsN..hp.h.sluloGRHPh.s........psp.l.h.tsFthh.ALuGsPsst.pphDptLAAsYL+Lspssps.t...................................	1	10	22	22
+8926	PF09094	DUF1925		Domain of unknown function (DUF1925)	Sammut SJ	anon	pdb_1k1x	Domain	Members of this family, which are found in a set of prokaryotic transferases, adopt an immunoglobulin/albumin-binding domain-like fold, with a bundle of three alpha-helices. Their function is, as yet, unknown [1].	21.10	21.10	21.40	26.60	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.92	0.72	-3.99	15	86	2009-01-15 18:05:59	2006-08-09 14:08:33	6	2	86	5	57	89	15	78.20	46	11.65	CHANGED	GhW+NFhsKYsEoNhMHKRMLtVSc+lpsh.......tsp......ApctLa+AQCNDAYWHGlFGGlYLPHLRcAlYcsLI+A-shL	......GhW+NFhsKYPESNhMHKRMLhlSpplpph........tptp.......spctLa+uQsNDsYWH.G.lFGGlYLPHLRcAlacplIcAEp..h...	0	27	41	47
+8927	PF09095	DUF1926		Domain of unknown function (DUF1926)	Sammut SJ	anon	pdb_1k1x	Domain	Members of this family, which are found in a set of prokaryotic transferases, adopt a beta-sandwich fold, in which two layers of anti-parallel beta-sheets are arranged in a nearly parallel fashion. The exact function of this family is, as yet, unknown, however it has been proposed that they may play a role in transglycosylation reactions [1].	19.60	19.60	21.50	21.10	17.40	19.50	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.56	0.70	-5.18	21	118	2009-12-15 10:48:00	2006-08-09 14:08:46	6	5	105	5	74	118	24	224.80	21	38.21	CHANGED	DhDhDGpcElhlpscsh.shlcsstGGslhElss+..sttaNasssLsRphEtYHctl..........ppptpslsohH-hsphhtc.hcccltaDhahRshhhD+hhpsstsL-shhpsp...p.uDh...sa.ht..tt.....lphhtct.h...hth.hplpKshplps...sslplpYplp.........pshshhaulElN..........LA...................lpuhtcshs..tscplplpD.ahhsclplc..hspssplathPlpTlSQSEtGa-hlhQulshhhhasl....ptphphplph	......................DhDhDGhcEhhhpspph.hhlpst.GGplhEh-hh..ttthNhhsshsRp.EhYaphh.........................t..t.t.....h..hcp....h.......tthh.D.h.+h.hhDphh..thshpph.tsp.......t.....a..h......ttt........hhh.t...h..........hplpKphphpp...ss..lplpYplp.......t..s...hphhausEhN.........lu..........................tth..p..t.........tspthth.-..hh.hph.lp...h.st.hphhhhPh.olo.po-.tGh-hh.Quhthhhhh.h......t.........h.........................	0	35	58	64
+8928	PF09096	Phage-tail_2		Baseplate structural protein, domain 2	Sammut SJ	anon	pdb_1k28	Domain	Members of this family adopt a beta barrel structure with a Greek key topology, which is topologically similar to the FMN-binding split barrel. They are structural component of the viral baseplate, predominantly found in the structural protein gp27 [1].	25.00	25.00	59.50	58.10	23.30	19.40	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.14	0.71	-4.62	6	29	2012-10-01 22:58:23	2006-08-09 14:44:45	5	3	27	3	0	28	0	166.00	58	42.44	CHANGED	hlspEPIshlVsEPRLlGQaIp.l-p.lsFDFEWLTKANsaTRsPacNsThYAHSFlDKphs+IlTG-GpNulslSRSGAYuDhTYRNGaEEusRLhThuQYDuYApspTaGNFsLTPGhKIpFaDpKNQF+sEFaVDEVIHElSpppSlTpLYMFsNSptlp.....cVKNE	..hlsQEPhshlVGEPpLIGQalQplchPlAaDFpWLTKuNt+sRsPhcNsTlYAHSFlDpphs+IosGcGpNSIlVSRSGuYS-hTYRNGaEEA.RLhTMAQYDGYAcCpohGNFsLTPGhKI.FhDsKNQF+s-FYVDEVIHElSNNsSlTpLYMFTNuppLc.....cVKNE..........	0	0	0	0
+8929	PF09097	Phage-tail_1		Baseplate structural protein, domain 1	Sammut SJ	anon	pdb_1k28	Domain	Members of this family adopt a beta barrel structure with a Greek key topology, which is topologically similar to the FMN-binding split barrel. They are structural component of the viral baseplate, predominantly found in the structural protein gp27 [1].	18.90	18.90	19.10	120.10	17.30	16.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.12	0.71	-4.73	5	31	2012-10-01 22:58:23	2006-08-09 14:44:55	5	3	30	3	0	31	0	194.80	57	49.04	CHANGED	QRsGYPNVSIKLYQsYDAWLENRFIELAATFlTLTMRDGLh.GlNEGLLQFYDuKNLHTKLsG-EIIQlSLKTANT.EpTaNRIYGIKHhuVoVDpKGDNIITFQLGSlHplcNLKFSRMFTNsAVsSVsEMIGsIYpDpPLLsPsIsuINshVPpsPWVsoINcYhcFVRcaGQoVEoE+FVaVWEDh-GIsIuDa	....QRsGaPNlSIKLY-sYDAWh-NRFlELAAThTTLTMRDuLY.GpNEGlLQFYDuKNlHTKMsGcpIIQISlpNANo.pplpoRIYGsKHauVSVDsKGDNIIsIpLusIHplcNLKFuRsFFssAsEolpEMlsVIYpD+sLLsPsINuINsYVPslPWsuohcsYhsaVRElGhuVtS-cFVFVWEDh.GIshhDY...	1	0	0	0
+8930	PF09098	Dehyd-heme_bind		Quinohemoprotein amine dehydrogenase A, alpha subunit, haem binding	Sammut SJ, Eberhardt R	anon	pdb_1pby	Domain	Members of this family are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase. They have a predominantly alpha-helical structure and can be divided into two subdomains, each binding a haem C group via a conserved CXXCH motif [1,2].	25.20	25.20	25.30	25.40	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.12	0.71	-4.81	11	50	2012-10-03 10:02:11	2006-08-09 17:04:58	5	5	42	4	19	60	5	135.40	38	33.92	CHANGED	tsGppllpppChuCHsspsss..thuRISpQRKTPEGW.MTlsRMphhHGlplos--RpslVKYLADpQGLAPuETcuhRYllERcPNshEpscstphophCuRCHStARluLQRRTspEWc+LlpFHLGQaPolEYQAhuRDR-WaslAhs-llPhLAcpYPh-osuW	...t.pGppllpspChuCHssptps....shsRIuppRKTPEG.W.MolsRMphhHGl.plos--+pslV+YLADppGLuPsEstshpYhh-+p.ss.-.ph.......s..hsphCuRCHShARhhLQRRstpEWppLlpaHluQaPohEhQA.uRDRpWh.lA.tphhs.Lucpashtp...........................	0	3	13	16
+8931	PF09099	Qn_am_d_aIII	DUF1927;	Quinohemoprotein amine dehydrogenase, alpha subunit domain III	Sammut SJ, Eberhardt R	anon	pdb_1pby	Domain	Members of this family, which are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase, adopt an immunoglobulin-like beta-sandwich fold, with seven strands arranged into two beta sheets; the fold is possibly related to the immunoglobulin and/or fibronectin type III superfamilies. The precise function of this domain has not, as yet, been defined [1,2].	21.20	21.20	21.20	21.20	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.36	0.72	-3.66	14	45	2012-10-03 16:25:20	2006-08-09 17:07:52	5	8	39	4	18	55	11	81.00	32	14.49	CHANGED	pspllAVpPshl+sGsc.sclslsGsuL.....suclsLusGlcVscVlppossplslcV+ssucApsG.RsVulGutp.ussLsVYs	...........tspllAVpPshl+AGsc.oplolsGouL.....sucssL...u.s..G...lcVscllp..posspltVcl+suA-ApsG.+plulGshp.sssLsVYp..........	0	7	14	15
+8932	PF09100	Qn_am_d_aIV	DUF1928;	Quinohemoprotein amine dehydrogenase, alpha subunit domain IV	Sammut SJ, Eberhardt R	anon	pdb_1pby	Domain	Members of this family, which are predominantly found in the prokaryotic protein quinohemoprotein amine dehydrogenase, adopt an immunoglobulin-like beta-sandwich fold, with seven strands arranged into two beta sheets; the fold is possibly related to the immunoglobulin and/or fibronectin type III superfamilies. The precise function of this domain has not, as yet, been defined [1,2].	25.00	25.00	131.60	130.70	19.20	15.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.84	0.71	-4.47	12	36	2009-01-15 18:05:59	2006-08-09 17:08:39	5	4	31	4	13	43	3	130.40	52	25.03	CHANGED	VKVsPsaulARlGGsGG..shPKh.upF-AhuahsGsDGKsGTsDDlclGslPAoWul-sFDEpAtcDpDs+YAGphpss.GlFsPusAGPNPtR+huTNNsGNLKVlATVc-u....uctlou-uphlVTV...QRassPPl	.VKVsPsauIARIGGsGu..s.hPKVtupFEA.AassGsDGcPtTtDDlRlGhlPAoWolEsFsEpAtcDcDl+aAGphpus.GlFsPusAGPNPcR+htTNNAGNLKVlATlsDG....up.loGEuHhIVTV...QRWNsPPl..	0	2	9	10
+8933	PF09101	Exotox-A_bind		Exotoxin A binding	Sammut SJ	anon	pdb_1ikp	Domain	Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for binding of the toxin to the alpha-2-macroglobulin receptor, with subsequent internalisation into endosomes. The domain adopts a thirteen-strand antiparallel beta jelly roll topology, which belongs to the Concanavalin A-like lectins/glucanases fold superfamily [1].	20.50	20.50	20.60	20.80	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.79	0.70	-5.27	2	97	2009-01-15 18:05:59	2006-08-10 09:38:45	5	7	59	4	3	94	0	187.30	43	28.60	CHANGED	E-thslasECtpsCsLs.csGh..pS+hSl.ssslhD...pGVLaYSMslpstpsslK.t.Dpu.SIho.G..hTlRhpt.........GV......p.NtshpYSYsRp.cGpaulNWLVPIGc-pPusIKl.lcELsttppl.chs.lYoI-hssphLt..KhttssoF.Vpt.EpN.....lAISasuVShhhAQtpspRcKRWucWtoGhsLChLsPhDulYNYlsQQpCsLsDsW.Gt.YcslAGsP....sKpsl-.KP..lppRlHF	.......................................CsLs.c.Gh..pSphSl.s.slhD...pGVLaYSMslpstpsslh.t.spu.SIho.G..hTlRhpt.........GV......p.NtshpYSasRp.cupaslNWLVPIGc-pPusIKl.lcELsttppl.chs.lYoI-hssphLt..c.ttssoF.Vpt.EpN.....lAISaPuVShKhApppGpRHKRWu+WtoGL...AhCWhlPl.uIYNYIsQtpCshuDsWhGt.YcslAGsP....sKpsl................................	0	1	2	2
+8934	PF09102	Exotox-A_target		Exotoxin A, targeting	Sammut SJ	anon	pdb_1ikp	Domain	Members of this family are found in Pseudomonas aeruginosa exotoxin A, and are responsible for transmembrane targeting of the toxin, as well as transmembrane translocation of the catalytic domain into the cytoplasmic compartment. A furin cleavage site is present within the domain: cleavage generates a 37 kDa carboxy-terminal fragment, which includes the enzymatic domain, which is then is translocated into the cytoplasm. The domain adopts a helical structure, with six alpha-helices forming a bundle [1].	21.60	21.60	22.60	208.90	21.30	16.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.89	0.71	-4.68	2	59	2009-01-15 18:05:59	2006-08-10 09:57:46	5	2	22	4	1	67	0	140.50	74	23.57	CHANGED	cGsuhuALsAHpsCtlPLEThsRpRpPRshpp..pCuY.sQplVuLalAsRl.asplDpVhp.sLsp.tst.....uDLtch.cppPt.sp.sLTlAtt..pcaVpptsG....pspAGAtuADllSLhCPsAstpC.AussD	..tNAMpALAAHRVCGVPLETLARSRKPRDLsDDLSCAYQAQNIVSLFVATRILFSHLDSVFTLNLDEQEPEVAERLSsLRpINENNPGMVTQVLTVARQIYNDYVTHHPGLTPEQTSAGAQAADILSLFCPDADKSCVASNND	1	1	1	1
+8935	PF09103	BRCA-2_OB1		BRCA2, oligonucleotide/oligosaccharide-binding, domain 1	Sammut SJ	anon	pdb_1iyj	Domain	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [1].	23.30	23.30	23.40	25.40	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.50	0.71	-4.40	19	188	2009-01-15 18:05:59	2006-08-10 11:08:30	5	33	140	3	119	199	1	125.00	36	6.93	CHANGED	Sul++IhEpDsssuphhVLhVSpl............................p.t.s.ttshlELoDGWYsl+utlD.sLpphlccG+lpl..GpKLh..........lpGAc...Lhu.scsssPL.E....sssslhLplshNuTRhAcWps..+LGhh+..hs	........................SAl++IhEpDssuupsh.VLCVSsIh.................................................................tpppsts.spp.sshlELTDGW.......Yul+Ap.LDs.sL....tphl...cp...G.....+..Lpl..GpKlh.....................lpGAc........Lhu.ss.csss.PL.E..................sspslhLplssNSTR.ApWts..+LGahtp..............................	0	65	79	100
+8936	PF09104	BRCA-2_OB3		BRCA2, oligonucleotide/oligosaccharide-binding, domain 3	Sammut SJ	anon	pdb_1iyj	Domain	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding [1].	21.10	21.10	21.20	23.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.84	0.71	-4.38	5	83	2009-09-11 15:20:08	2006-08-10 11:09:07	5	17	53	3	44	85	0	137.90	45	5.33	CHANGED	REsLcFo+LLDPuFQPPCSEVDlVGlVVSV..V+spGLAPlVYLSDEChNLLsVKFWsDLN....EDIlKP+VLIAASNLQWR.PEu+SsIPTLFAG-aSsFSASPKEsHFQE+FscM+pTlE..NIDoFYcEAEpKLlcLLsuNsPK	...............RcslpFscLh-PsFpPsCuEVDllGhVlSV.......s+p....t..GhuPhVYL.S....DEsaNL.LulKFWtDLs....EDIlKPpsLIAASNLQWR...s-op...Ssl..PoLaAGDhSsFSA.sPKEuHhQEsFschKsslc..Nls..hFhs-AEpKL.hclLptp....................	1	10	14	27
+8937	PF09105	SelB-wing_1		Elongation factor SelB, winged helix 	Sammut SJ	anon	pdb_1lva	Domain	Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding [1].	25.00	25.00	25.40	148.40	23.10	23.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-8.84	0.72	-4.31	2	2	2009-01-15 18:05:59	2006-08-10 11:45:38	5	1	2	3	1	5	0	61.00	100	9.62	CHANGED	GSPEKILAQIIQEHREGLDWQEAATRASLSLEETRKLLQSMAAAGQVTLLRVENDLYAIST	GSPEKILAQIIQEHREGLDWQEAATRASLSLEETRKLLQSMAAAGQVTLLRVENDLYAIST	0	1	1	1
+8938	PF09106	SelB-wing_2		Elongation factor SelB, winged helix 	Sammut SJ	anon	pdb_1lva	Domain	Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding [1].	21.50	21.50	21.60	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.64	0.72	-4.04	67	966	2009-01-15 18:05:59	2006-08-10 11:46:27	6	14	953	6	177	683	32	57.80	44	9.28	CHANGED	llstLspaHpcpP.c.Gls+-cL+...Rhst.ths....splaptllppLhppGplttptshl+L	......lL-sLAsYHEpHtDcsGsuRERLR......RhAlPht-.................-sLl...hhLI-chp-sGtIhsc+GWLHL.............................	0	66	113	151
+8939	PF09107	SelB-wing_3		Elongation factor SelB, winged helix 	Sammut SJ	anon	pdb_1lva	Domain	Members of this family adopt a winged-helix fold, with an alpha/beta structure consisting of three alpha-helices and a twisted three-stranded antiparallel beta-sheet, with an alpha-beta-alpha-alpha-beta-beta connectivity. They are involved in both DNA and RNA binding [1].	22.20	22.20	22.60	22.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.40	0.72	-4.57	95	1262	2009-01-15 18:05:59	2006-08-10 11:47:24	6	13	1235	10	249	928	241	50.30	43	8.23	CHANGED	ltphhp..p..ssplssuphR-hl.GhoRKhulslLEahDctthT+RtG..-.pRhlp	.............tpl.p..c...sGuhssA-FRDtL....s.....luRKhAItlLEYFDRh.GaTRRcG...s.c+lLR.......	0	93	169	217
+8940	PF09108	Xol-1_N		Switch protein XOL-1, N-terminal	Sammut SJ	anon	pdb_1mg7	Domain	Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and six antiparallel beta sheets, in a beta-alpha-beta-beta-beta-alpha-beta-alpha-alpha-alpha-beta arrangement. The fold of this family is similar to that found in ribosomal protein S5 domain 2-like [1].	25.00	25.00	25.00	32.40	18.90	24.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.02	0.71	-4.56	2	12	2012-10-03 01:04:38	2006-08-10 13:53:43	5	3	5	2	11	15	0	147.40	27	40.39	CHANGED	lc+Sps.Pl....Ep-sssNh.ssKlsu.APHsVchMsShhhAlN+.Chsps+s..spcP+SupEHhI.-hscphHsphphullRshlcpLcLppVYcIphhs.hD.sG+lu.hshLlAlW+s.............LKSh.psh.tpFt..........DshhS	.........p..ph.p..t......................tpphsu...APHVVpluss...sahAVN+hClVpupllpp+.PpssppH..hI.phstc.psp.phslltphlccLpL+.psYcIpIhsthDassphu...hhshLsAIWKShsh...........p....h........h...tp.................h.................	0	1	2	11
+8941	PF09109	Xol-1_GHMP-like		Switch protein XOL-1, GHMP-like	Sammut SJ	anon	pdb_1mg7	Domain	Members of this family, which are required for the formation of the active site of the sex-determining protein Xol-1, adopt a secondary structure consisting of five alpha helices and seven antiparallel beta sheets, in a beta-alpha-beta-alpha-alpha-alpha-beta-beta-alpha-beta-beta-beta arrangement. The fold of this family is structurally similar to that found in the C-terminal domain of GHMP Kinase [1].	25.00	25.00	28.00	27.20	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.15	0.71	-4.21	2	10	2009-01-15 18:05:59	2006-08-10 13:54:42	5	2	5	2	9	12	0	170.80	24	43.23	CHANGED	VthlAE.................aDhVFVpTsLHs.caTPphF.sptpsKh...tFpp.c-pspaPD..hst.MshaScpRVtppshss..l.h.op.uLctl.ppcppl.GFElQQGGhLVsLKKssFhsDc..hIphhuhhlts-pppSlppl.FcLLc.G.tup.hp.s..+hh-.pp+sslplchKsVp	..........................pssphhshhu..................tF.cpaDllFV+TNLH......sScFcPp..h...s+..pps+s..cthpp....c-ssph.scs..lsthMhthScsRhspEs.h..s...hpphEpDCcsAlpphp.ppc.pp...l...cGFEVQQGGILllLKKssFhssc....LLcsIuhuItcpsp..t.ploplSFsLLpPutsu..p...........................h.................	0	1	2	9
+8942	PF09110	HAND		HAND	Sammut SJ	anon	pdb_1ofc	Domain	The HAND domain adopts a secondary structure consisting of four alpha helices, three of which (H2, H3, H4) form an L-like configuration. Helix H2 runs antiparallel to helices H3 and H4, packing closely against helix H4, whilst helix H1 reposes in the concave surface formed by these three helices and runs perpendicular to them. The domain confers DNA and nucleosome binding properties to the protein [1].	21.00	21.00	21.20	21.20	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.36	0.71	-3.68	29	385	2009-01-15 18:05:59	2006-08-10 14:51:15	6	11	236	5	260	400	3	101.60	46	10.01	CHANGED	SlDsYYKDlLpsGspssp.......spsPRsPKphslpDaQFaPspLhcL.E+Ephaa+KplsYKsshp-sss............................cs.p-+cpcpchEQccI-NApPLTEEEpp.KpcLhpEG	.....................ulDsYa+-AL+...supsps...........PKsPRsPKQsslpDFQFFP.PRLhELhEKE..hhaa+KplGYKVsh.s.s.......................................phspttttpc.EQpcIDpApPLT-EE.pEK-cLlspG..............................................................................................................	0	70	132	206
+8943	PF09111	SLIDE		SLIDE	Sammut SJ	anon	pdb_1ofc	Domain	The SLIDE domain adopts a secondary structure comprising a main core of three alpha-helices. It has a role in DNA binding, contacting DNA target sites similar to c-Myb (Pfam:PF00249) repeats or homeodomains [1].	20.80	20.80	21.00	24.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.29	0.71	-4.37	36	454	2009-01-15 18:05:59	2006-08-10 14:52:14	5	18	282	5	306	466	4	115.10	47	11.41	CHANGED	a-KhlppIEpGEcKhp+hppppchLcpKlpphcsPhp-Lplp....Ys..ssp++sYo--EDRFlLshlt+hGh..t.sha-cl+ppI+psPhF+FDWFhpSRTspEluRRssTLlphlp+Ehp	.........-KhhtpIEcGEt+lp+ptphc+uLcpKlspY+.sPhppL+Ip..............Yu.....ssp......tKsYoEEEDRFLlsMLaK.hGh.-p-....slY-clRpsIRpuP.FRFDWFlKSRTshELpRRCsTLlshIE+E............	0	101	169	249
+8944	PF09112	N-glycanase_N	PngaseF_N;	Peptide-N-glycosidase F, N terminal	Sammut SJ	anon	pdb_1pgs	Domain	Members of this family adopt an eight-stranded antiparallel beta jelly roll configuration, with the beta strands arranged into two sheets. They are similar in topology to many viral capsid proteins, as well as lectins and several glucanases. The domain allows the protein to bind sugars and catalyses the complete removal of N-linked oligosaccharide chains from glycoproteins [1].	17.80	17.80	17.90	19.10	17.60	17.50	hmmbuild  --amino -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.36	0.71	-4.90	16	80	2009-01-15 18:05:59	2006-08-10 15:15:43	5	4	67	8	27	83	150	166.50	33	34.00	CHANGED	slsVF-ctplpFssssh.......tts...th.ttphhLpplpLPs..htcsh.slpLcls.tssG...Ds...WD+oGol..FVlPcssshph.s.htp...........................slELhRFhTPFtluphs....................psVsacpDlosLhPhLpG.cshlshahssWsttG.....ahsSlclch	............................pl.VF-pp.lpFssshh.......ttss.hphssGpllLKKlpLPs..hpcs.h.slplclsltSsG......Dt....WD+oGSs..FVlPcs.sshshhs.htps.tthP.hps.php..h.GllsstpY.sslELMRFhTPFGVupas..........h...lhh.pW.psV.appDlTcLhPlLc.....u.-salGlaIssWs...tcG.....ahsShclch......................................	5	10	22	26
+8945	PF09113	N-glycanase_C	PngaseF_C;	Peptide-N-glycosidase F, C terminal	Sammut SJ	anon	pdb_1pgs	Domain	Members of this family adopt an eight-stranded antiparallel beta jelly roll configuration, with the beta strands arranged into two sheets. They are similar in topology to many viral capsid proteins, as well as lectins and several glucanases. The domain allows the protein to bind sugars and catalyses the complete removal of N-linked oligosaccharide chains from glycoproteins [1].	25.00	25.00	42.90	37.50	17.10	16.80	hmmbuild  --amino -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.19	0.71	-4.49	23	91	2009-01-15 18:05:59	2006-08-10 15:17:00	5	6	75	8	36	95	190	148.10	34	28.22	CHANGED	psYssh....................t.shsh...sFslPsss+pscLhsllTGHG.......spssssEFs.psHplhVsGpps....hphhsht.sCAshth.sss....pGsWh...........................huRusWCPGpslpPhpl-lsshhssspthssslshtshhsGsp............uhhhhSuaLl	........................pYsph.hspc.slsh...sFslspss+sscLchlsTGHG.......GasGGDEFst+ppplhlDGppl....hsahPWRp-CuoaRpaNPu..........oGsWh.......................uSSDhSRSNWCPGsslsPphlslssltsGpHohslsIPtut.h-Gsp............saWhlSuhLl...............................	0	18	30	35
+8946	PF09114	MotA_activ		Transcription factor MotA, activation domain	Sammut SJ	anon	pdb_1bja	Domain	Members of this family of viral protein domains are implicated in transcriptional activation. They are almost completely alpha-helical, with five alpha-helices and a short, two-stranded, beta-ribbon. Four alpha helices (alpha1, alpha3, alpha4 and alpha5) are amphipathic and pack their hydrophobic surfaces around the central helix alpha2 [1].	26.10	26.10	27.10	26.50	25.70	26.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.21	0.72	-4.23	3	22	2012-10-04 14:01:12	2006-08-10 15:54:45	5	2	21	3	0	19	0	93.10	56	44.63	CHANGED	SKVTYIIKASNNA.LNEKTAsIhIpIAKKsFITAAEVREuVcsEhNsuVVNSNIGVLIKKGLVEKSGDGLIsTGEApDIIscAA-LaAQENAPELLK	..........SKlTYIIKASpss.LNEKTAuILIpIAKKsFITuuEVRE.lp.-husAVVNSNIGVLIKKGLlEKSGDG.LlhTuEupDIlppAAsLaApENAPEhL...........	0	0	0	0
+8947	PF09115	DNApol3-delta_C		DNA polymerase III, delta subunit, C terminal	Sammut SJ	anon	pdb_1a5t	Domain	Members of this family, which are predominantly found in prokaryotic DNA polymerase III, assume an alpha helical structure, with a core of five alpha helices, and an additional small helix. They are essential for the formation of the polymerase clamp loader [1].	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.43	0.71	-4.07	41	817	2009-01-15 18:05:59	2006-08-11 10:11:52	5	2	811	9	97	453	22	117.10	43	36.28	CHANGED	p.t.hppRpphhpshhpshpspsh..lpLlshls..ccps.tpLcWLtsLLhDAlKhphGlsp.hhhNtD.hshlpplupphssptLhpthpplhph+ppLhplsulNpELLLhchLlphpp.h...l	....................................t.s-pWptRcsLCQuL.h..ulp.osDh..huLL..sALN...HE..pAssRLaWLuoLLhDALKt+aGAup..lsNsDhsslVspLAspLSsu+Lpsllscls+hR-QLhsVoG..lNRELLlTDhLL+lEch..............	0	20	42	70
+8948	PF09116	gp45-slide_C		gp45 sliding clamp, C terminal	Sammut SJ	anon	pdb_1b77	Domain	Members of this family are essential for the interaction of the gp45 sliding clamp with the corresponding polymerase. They adopt a DNA clamp fold, consisting of two alpha helices and two beta sheets - the fold is duplicated and has internal pseudo two-fold symmetry [1].	25.00	25.00	25.80	33.30	22.00	24.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.34	0.71	-10.38	0.71	-4.09	9	69	2009-01-15 18:05:59	2006-08-11 11:03:52	5	2	67	21	1	60	670	110.60	33	49.59	CHANGED	sVhF-lcA-DhpQLh+sSpslplDslulssc-G..+IVlsuapph.Dus.spspaSlslu.-a-Gss.sFsFllphsNMKhhs...ucYKVhlhu.......chAupFputpss..YllAhEscSoasF	.....sVpFc..Lcu-cLppLh+supshplsslslsscsG....+lVlss.....cp.....spspspYSlp.l.G.-h-sss..FsFslphpNhKhls...GcYcVhlss.......ptsupFpup..s..hs..YhlALEsss............	0	1	1	1
+8949	PF09117	MiAMP1		MiAMP1	Sammut SJ	anon	pdb_1c01	Domain	MiAMP1 is a highly basic protein from the nut kernel of Macadamia integrifolia which inhibits the growth of several microbial plant pathogens in vitro while having no effect on mammalian or plant cells. It consists of eight beta-strands which are arranged in two Greek key motifs. These Greek key motifs then associate to form a Greek key beta-barrel [1].	21.80	21.80	22.80	22.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.82	0.72	-3.56	2	31	2012-10-01 23:14:22	2006-08-11 11:26:43	5	1	12	1	19	30	0	78.70	46	75.83	CHANGED	ShFTsWuGPGCNN+AtRYSKCGCSsItpp..GGY-F.YpGQTAAhYNpssCpGVApTRFuSSs.pACssFGWKShFIQC	..............SYFssWuGPGCNN.....chtRYS...sCGCoNluss.H.GGYcFsYQ.GQTAusYNsssCpGVspTRFS....s....os.QsCu..s.FGWpShFIQC...............................................................	0	0	16	19
+8950	PF09118	DUF1929		Domain of unknown function (DUF1929)	Sammut SJ	anon	pdb_1k3i	Domain	Members of this family adopt a secondary structure consisting of a bundle of seven, mostly antiparallel, beta-strands surrounding a hydrophobic core. The 7 strands are arranged in 2 sheets, in a Greek-key topology. Their precise function, has not, as yet, been defined, though they are mostly found in sugar-utilising enzymes, such as galactose oxidase [1].	25.00	25.00	27.80	27.60	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.47	0.72	-3.90	68	596	2009-01-15 18:05:59	2006-08-11 11:52:05	6	64	224	13	381	626	15	99.90	29	14.34	CHANGED	RPslss.s.....s........ssl....saGsshslss..........ss......shspssLl+sussTHuhshsQRhl.Lsh........tsst....ssp.hssshP..sss..s.lssPGaYMlFlls.sG....lPShuphVpl	........................................RPslss..s..s..........ssl..shG.s.s.hsls.hp...................ss..........shhpssLlpsuhsTHohsh.sQRhl.Lsh............................ssss......sts..hslshP..sss...slsPPGaYMLFlls.sG......lPS.h.u.phVpl........................	0	152	263	339
+8951	PF09119	SicP-binding		SicP binding	Sammut SJ	anon	pdb_1jyo	Domain	Members of this family bind the chaperone SicP, which is required both to maintain the stability of SptP, as well as to ensure the eventual secretion of the protein. The domain is found in the Salmonella effector protein SptP, which interacts with SicP chaperone dimers mainly through four regions of its chaperone-binding domain. The structure of the SptP-SicP complex contains four molecules of SicP, aligned in a linear fashion and arranged in two sets of tightly bound homodimers that bind two SptP molecules. The SicP homodimers do not interact with each other, but are held together by a molecular interface formed between two SptP molecules. Each SptP molecule is wrapped around by three SicP chaperones (two chaperones from one homodimer and a third one from the opposite homodimer pair) [1].	25.00	25.00	25.50	38.20	24.20	19.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.48	0.72	-4.28	3	136	2009-09-10 17:21:18	2006-08-11 13:28:16	5	3	135	2	4	70	0	81.50	68	14.40	CHANGED	A+EGFKEKLLoaLSHlPLLKNT-AVQ+YsEslRl-N++lLpVFLpALocRYGc-AApDAlDhuclssssPLTQRpl...VQITE	...APEKFSSKVLTWLGKMPLFKNTEVVQKHTENI+sQDQKILQTFLpALTEKYGETAVNsALLMSRIN.MN.KPLTQRLA...VQITE..	0	1	1	2
+8953	PF09121	Tower		Tower	Sammut SJ	anon	pdb_1mje	Domain	Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA [1].	25.00	25.00	25.10	48.10	24.80	23.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-8.14	0.72	-4.02	9	69	2009-01-15 18:05:59	2006-08-11 14:43:34	5	13	38	3	30	70	0	41.90	65	1.52	CHANGED	MEKpssGhhlFRNpRtEE+EAt+aupsQQKKLEsLFoKIQsE	MEKTsoGhYIFRNERtEEKEAsKaAEsQQKKLEALFsKIQsE.	0	4	6	13
+8954	PF09122	DUF1930		Domain of unknown function (DUF1930)	Sammut SJ	anon	pdb_1okg	Domain	Members of this family are found in 3-mercaptopyruvate sulfurtransferase, and have no known function. They adopt a structure consisting of a four-stranded antiparallel beta-sheet and an alpha-helix, arranged in a beta(2)-alpha-beta(2) fashion, and bearing a remarkable structural similarity to the FK506-binding protein class of peptidylprolyl cis/trans-isomerase [1].	20.10	20.10	21.00	90.50	19.40	19.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.25	0.72	-4.20	3	12	2012-10-02 13:30:10	2006-08-11 15:37:18	5	1	12	1	3	13	0	68.20	59	18.13	CHANGED	MLhpMhSPSLGDNPKAsL.DssTLlVDGslVspPDAELpSAlsHLHlGE+ApVaFKSpRVVVIEV.PtlP	MhhpM.oPsLGDNPKAsL.DshTLhVDGssscpPDAElpSAhsHLHhGEtApVaFKStRVVsIEV.Phls....	0	1	2	3
+8955	PF09123	DUF1931		Domain of unknown function (DUF1931)	Sammut SJ	anon	pdb_1r4v	Domain	Members of this family, which are found in a set of hypothetical bacterial proteins, contain a core of six alpha-helices, where one central helix is surrounded by the other five. The exact function of this family has not, as yet, been determined [1].	28.20	28.20	28.20	80.60	25.60	28.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.46	0.71	-4.22	14	60	2009-01-15 18:05:59	2006-08-11 15:53:48	6	1	55	10	36	63	1	137.20	42	90.89	CHANGED	h-+lFRpsAuLDlc..Ks-hcRhsDhVpcKlYDLLlsuptsAptNsRDlIc.hDLPITKGLpEoIcpF+pl..-c-lELcsIL-hLA...........shPPLDhslupEscscLP-IsGGLslslARshKhlcP-lKs..PpsEchEcspplhD	.F-+lFRpAAGLDVD..KsDlKRhsDhVccKlYDLlllAptsAKuNsRDlIc.hDLPITKGLpESl+pF+pl..DcclELcPlL-tLs...........shPPLDlslu--scscLP.IsGuLsVAlARshKtlcP-lKN..PpspHaEcApclhc....	0	15	25	33
+8956	PF09124	Endonuc-dimeris		T4 recombination endonuclease VII, dimerisation	Sammut SJ	anon	pdb_1e7l	Domain	Members of this family, which are predominantly found in Bacteriophage T4 recombination endonuclease VII, adopt a helical secondary structure, with three alpha helices oriented parallel to each other. They mediate dimerisation of the protein, as well as binding to the DNA major groove [1].	21.60	21.60	21.60	21.60	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.64	0.72	-4.34	8	37	2012-10-03 03:04:30	2006-08-14 09:14:20	5	2	35	10	1	30	0	53.20	48	34.94	CHANGED	IHPpalsDpsKpFSRLs+sEMhAEMpucGF-Ys-sDsKspLscpF+KQhhKul+	.....IHPpalsDKsKcFSRLsKpEMhAEM.ppGF-YN-uDTKspLltsFKKQl+KulK.......	0	1	1	1
+8957	PF09125	COX2-transmemb		Cytochrome C oxidase subunit II, transmembrane	Sammut SJ	anon	pdb_1ehk	Domain	Members of this family adopt a tertiary structure consisting of two antiparallel transmembrane helices, in a transmembrane helix hairpin fold [1].	25.00	25.00	25.10	25.10	22.40	21.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.04	0.72	-4.41	2	13	2009-09-11 15:01:49	2006-08-14 09:34:59	5	1	13	26	6	15	2	37.60	62	22.94	CHANGED	DEHKAHKAILAYEKGWLAFSLAMLFVFIALIAYTLATH	.....DEHKAHKAILAYEKGWLsFuLAMllVFIALIAYTLATH...	0	1	4	6
+8958	PF09126	NaeI		Restriction endonuclease NaeI 	Sammut SJ	anon	pdb_1ev7	Domain	Members of this family adopt a secondary structure consisting of nine alpha-helices, six 3-10 helices and 13 beta-strands. They bind two GCC-CGG recognition sequences to cleave DNA into blunt-ended products [1].	25.00	25.00	101.80	101.60	18.90	17.30	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.58	0.70	-5.77	6	31	2012-10-11 20:44:45	2006-08-14 09:51:55	5	1	28	4	10	34	1	279.50	35	60.68	CHANGED	Dt-LLhshts.hoscssGch.....huuhLRcCIDsVl.s.+TGRhsa--L-KTEKTaIGTcVEIELRAhhphscG.chDh.......Ihs.sVDlKhoM.GuNWMlPsEulDs.lCLLVtADEt+ARhhlGLlhsRPsaLTpup..N+DuKpslospG.huslLWLhpDH.PhPtNhhhplsscshspIFAspo......GssRhAcLFRclQtcPIsRsVlcAVApQcDFMRRlRust..GsRslLccEGILlLuGp.hDspLhpALsLPsssuupalSsRlhhtc.tch.............st.suD.llpLs	.......................hhht..hphcssGph.....hutslRcolDpllDsp+TGRasa..cpLpKTEKTalGThlEIpLpcpFt..h..sc.G......phDh.......ItGh-VDsKaohp...ttsWMIP.Euh............sp....hsLlltAD-ppupassGLl+scs-hL......st.ut........NRDuKpslo.....spu.+pt.lhWLacct..Ph.tNhLLpLst.pshppIh.u.spS.......GppRlspLFRplppp.lsRslVtsV.A.pQcDaM+RlR.su..GuRshLp.EGIllLusp...pctplApsLsLPhsstuEalSsRls.tp.tct.t.ts.hts..WhhA..s-......s.........................	0	0	5	9
+8959	PF09127	Leuk-A4-hydro_C		Leukotriene A4 hydrolase, C-terminal	Sammut SJ	anon	pdb_1hs6	Domain	Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase [1].	21.20	21.20	21.20	21.40	20.90	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.70	0.71	-4.59	37	628	2012-10-11 20:01:01	2006-08-14 10:36:11	6	10	372	47	367	640	57	142.00	25	23.77	CHANGED	oLscsshsLup.cWhst..t.......stphsstDlpsasspQhlhFLspL............hptps...ls.pp..lptLscsY..plssSpNuElth+ahplsl+....uphp..shhsphtcaL..sphGRMKFlRPlY+tLsp.....hs+phAlcsFpct+stYHPlspthVpKDL	...........................................................hhp.s.tLup.tWhpt..t.................ttshsstsh.psasspQhlhFLspL.........................h..tps.....Ls.pp..lppL..sc.sY..plssopN.u.El.phRW..hplslc....sc....ap....ssh..tstcaL.......pp..GRhKastPLYcsLhp....ttscshAhcsFtps+sthHPlstthlpc.L......................................	0	113	181	274
+8960	PF09128	RGS-like		Regulator of G protein signalling-like domain	Sammut SJ	anon	pdb_1htj	Domain	Members of this family adopt a structure consisting of twelve helices that fold into a compact domain that contains the overall structural scaffold observed in other RGS proteins and three additional helical elements that pack closely to it. Helices 1-9 comprise the RGS (Pfam:PF00615) fold, in which helices 4-7 form a classic antiparallel bundle adjacent to the other helices. Like other RGS structures, helices 7 and 8 span the length of the folded domain and form essentially one continuous helix with a kink in the middle. Helices 10-12 form an apparently stable C-terminal extension of the structural domain, and although other RGS proteins lack this structure, these elements are intimately associated with the rest of the structural framework by hydrophobic interactions. Members of the family bind to active G-alpha proteins, promoting GTP hydrolysis by the alpha subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor signalling pathways [1].	21.10	21.10	21.30	21.10	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.03	0.71	-4.80	9	251	2012-10-03 22:10:09	2006-08-14 11:04:46	6	13	79	9	111	223	0	172.50	40	14.50	CHANGED	psusFQsl-.L....KSRPAHLAVFL+aVloQh.DPusLLsYLhu.DhYpp..ssuKEsR+hhh-hashFL-+sA.sL+lsls-plsh-l..........................ptp+scLhsp-htRthlppspppshs-lpcpLpD.............FRpKRoMGLs.hpuEhspL-t.httDhs....+ERpsA.Eplls+l...t-lL.stpshE..E-+osshpaslhTYM++lGV+	........................................su.FQslEhL....KpRPAHLuVFLpaVhSQh..DPuPLL..........hYLhu.-hYpp......ss..sK-....sR+hhh-haphFL-+sA..sL+V.p.l.P-..plsh-l..........................-h.h.cs-.Lhsp-hhRphl.pphpppshs-lpcpLcD.............F..Rp..KRohGLssh.uEhstL-..hstDph......+ERpsA...Ep.l.l.sp..l..........t-hl...p....p..s.E.......E.-+Ssshthsl.hYMpHhGl+..................................................................	0	25	34	64
+8961	PF09129	Chol_subst-bind		Cholesterol oxidase, substrate-binding	Sammut SJ	anon	pdb_1i19	Domain	The substrate-binding domain found in Cholesterol oxidase is composed of an eight-stranded mixed beta-pleated sheet and six alpha-helices. This domain is positioned over the isoalloxazine ring system of the FAD cofactor bound by FAD_binding_4 (PF:PF01565) and forms the roof of the active site cavity, allowing for catalysis of oxidation and isomerisation of cholesterol to cholest-4-en-3-one [1].	25.00	25.00	27.90	27.90	19.30	16.30	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.89	0.70	-5.30	3	72	2012-10-02 00:48:38	2006-08-14 11:36:47	6	3	62	4	14	78	1	295.20	57	53.89	CHANGED	RhRCQSYVDIPASELFAPAGScGRTFESFVp+SGRAEAIWFPFTDKPWLKVWTVoPT+PsG...................ARsVsGPYNYPFSDNIPcslSDLluAIN.sGcPpLAPLFGKsQY-IThLGLAsThG..sDLWGWSKDVLaYIKPTTLRVTANGYAVLTRRcNVQRVINEFsttY+pRIAsYRAsG+YPlNGPVEIRVoGLDQPADVtVPGAsPPSLSAIRPRPDHPDWDsAIWLDILolPGTPsANcFYREhEQWMhSHYSGDYATlRPEWSKGWGYuPsAAWoDsslVssplssoaRpGLsss-NWDoAlRpLNchDPHRVFSSPLLDRLMP	........................RhRCpSassIPAsELFA.AsGo..s.G....RTh-SFlp+SGRsEAIWFPFT-pPWLKVWTssPs+P.s...................uRsVstPYNYPFSDsIPctloDLlupIs.sG.pstLsPLhGphQYslshsGLshThs.........hDLWGWS+slLhYl+PTTLRVTANGYAVLTRRtslQRVIsEFsthYpphlstY+AtGcYPhNGPlEIRVoGLDpPu-sh.sGAhsPoLSAlRPRPD..+PE..WDsAIWhDlLolPGTPtAstFYREhEpWhhsp..aoGsYAolRsEWSKGWGYss.sAAWsDsshlsphlsp.hRpG.lsusssWDsAhtpLschDP+RlFSSPLLDRLhs................	0	4	11	13
+8962	PF09130	DUF1932		Domain of unknown function (DUF1932)	Sammut SJ	anon	pdb_1i36	Domain	This domain is found in a set of hypothetical prokaryotic proteins. Its exact function has not, as yet, been described.	25.00	25.00	25.00	25.10	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.30	0.72	-4.24	45	239	2009-01-15 18:05:59	2006-08-14 11:43:05	6	8	206	4	130	266	129	73.40	27	24.62	CHANGED	AcphGVp-pllsoLspohPuhsh..ppsshhlscshtHuhRRstEMcElucTlpssGl.........sst...hspusAshhpphuc	..............AcphGVt-tllssLspoh.Puhs...phsshhlspss.HuhRRspEMc.Elucslp-sGl.........................ssh....hscusAphhptls.........	0	32	77	108
+8963	PF09131	Endotoxin_mid		Bacillus thuringiensis delta-Endotoxin, middle domain	Sammut SJ	anon	pdb_1i5p	Domain	Members of this family adopt a structure consisting of three four-stranded beta-sheets, each with a Greek key fold, with internal pseudo threefold symmetry. Thus they act as a receptor binding beta-prism, binding to insect-specific receptors of gut epithelial cells [1].	21.20	21.20	21.70	21.50	20.00	21.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.39	0.71	-4.86	3	68	2009-01-15 18:05:59	2006-08-14 13:04:28	5	5	9	1	0	63	0	192.60	70	32.83	CHANGED	LLVSSGANLYASGSGPQQTQSFTAQNWPFLYSLFQVNSNYVLSGlSGARLoITFPNIGGLPGSTTTQoLpuARVNYSGGVSSGpIGusNLNQNFNCSTlhPPLSTPFVRSWLDSGTDREGVATSTNWQTESFETTLuLRCGAFSARGNSNYFPDYFIRNISGVsLVIRNEDLsRPLYYNEIRNIESPSGTPGGARAYLVSVHNRKN	....................LLVSSGANLYASGSGPQQTQSFTuQsWPFLYSLFQVNSNYVLsGhSGARLohTFPNIsGLPGSTTTpuLhuARVNYSGG.........l.SSGpIG....u....osh.....NQ............N.................FN...C.STlhPPL.TPFVRSWLD...SGoDREGVATsTNWQTESFETTLuLRsGAFoAR.GNS.NYFPDYFIRNISGVsLVlR.NEDLpRPLHYNEIRNItSPSGTPGGARAYhVSVHNRKN.......	0	0	0	0
+8964	PF09132	BmKX		BmKX	Sammut SJ	anon	pdb_1rji	Domain	Members of this family assume a structure adopted by most short-chain scorpion toxins, consisting of a cysteine-stabilised alpha/beta scaffold consisting of a short 3-10-helix and a two-stranded antiparallel beta-sheet. They are predominantly found in short-chain scorpion toxins, and their biological method of action has not, as yet, been defined [1].	20.70	20.70	24.70	29.20	20.00	19.70	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-7.50	0.72	-4.08	2	14	2009-01-15 18:05:59	2006-08-14 14:09:14	5	4	4	2	5	15	0	29.90	55	20.45	CHANGED	PhsspCKscpDssMCshGhSsKsGhCpuCT	PVsGECKscsDAsMCTsGsssKs.GTCTuCT...	1	5	5	5
+8965	PF09133	SANTA		SANTA (SANT Associated)	Zhang D, Mistry J	anon	Zhang	Domain	The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota.  It is sometimes found in association with the SANT domain (Pfam:PF00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling [1].  Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes [1].  Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions [1].	20.90	20.90	21.10	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.21	0.72	-4.03	7	120	2009-01-15 18:05:59	2006-08-14 14:20:17	5	5	73	0	79	112	0	91.90	32	12.64	CHANGED	lpLpDWhlKphsps.....ltlcGh.cspps...hhasSshIscRhpsshLcs.sGhhhsLhGhl..............sppph.csGhs.clhccFhhGFP..Wcchh.st.	.........................................lpLp-Whlc.hhss.s................tlsVpGh..tsp...ss...........hha+...S.....ssIlcRhppspLcThsGplYhLpGhl..............sp.phccs..G..aPstl.......hc+Fhh......G....FPcpWcchlpp..h.........	0	21	35	58
+8966	PF09134	Invasin_D3		Invasin, domain 3	Sammut SJ	anon	pdb_1cwv	Domain	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, arranged in a Greek-key topology. It forms part of the extracellular region of the protein, which can be expressed as a soluble protein (Inv497) that binds integrins and promotes subsequent uptake by cells when attached to bacteria [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.30	0.72	-4.14	2	269	2012-10-03 16:25:20	2006-08-14 14:36:03	5	18	254	1	6	214	8	102.50	72	8.12	CHANGED	PDsspSSFsVSssDIlADGoMpShLoFVPhsKNscFlSGhpsLpFhQsGVPVoISPlTEpsDsYTAoVVGNosGDVsITPQVss..LshLQK+IoLaPl	.....M.DVANS..TLSANEPSGDVVADGQQAYTLTLT..AVDSEGNPVTGEAS.....R...L.RF...V..PQ....D.T.......N....G....VTV...G..A...I...S...E.IK..P...G..V...Y.SA...T.VSSTRAGNVVVRAFSEQYQLGTLQQTL.....KFVA............	0	0	2	2
+8967	PF09135	Alb1		Alb1	Mistry J, Wood V	anon	manual	Family	Alb1 is a nuclear shuttling factor involved in ribosome biogenesis [1].	20.40	20.40	23.00	23.00	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.79	0.72	-3.45	48	156	2009-01-15 18:05:59	2006-08-14 14:58:35	6	1	117	0	115	151	0	110.10	28	63.64	CHANGED	h+SRAARRtss.shs.h-+.......p.lpsls....sccsshp+stlhsspp.......suslsccp..t...+spc.....ls.+tpp..........hpppsh-+AthlhcpLspKhsKSlsR.uKhlpp..R+ssW-phNpphppp	.............................hpSRAARptspsshs.h-+.......p.h.p.sls....sccsshp+stlhsst+.............suulsccp.......+spp.......ls..ppppp...............tpccuhc+AphshcpLspKlsKSlsR.sKhlpp..R+tsW-phNpph...t............	0	16	54	96
+8968	PF09136	Glucodextran_B		Glucodextranase, domain B	Sammut SJ	anon	pdb_1ug9	Domain	Members of this family adopt a structure consisting of seven/eight-strand antiparallel beta-sheets, in a Greek-key topology, similar to the immunoglobulin beta-sandwich fold. They act as cell wall anchors, where they interact with the S-layer present in the cell wall of Gram-positive bacteria by hydrophobic interactions. In glucodextranase, Domain B is buried in the S-layer, and a flexible linker located between domain B and the catalytic unit confers motion to the catalytic unit, which is capable of efficient hydrolysis of the substrates located close to the cell surface [1].	29.80	29.80	30.50	31.50	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.24	0.72	-3.82	2	5	2009-01-15 18:05:59	2006-08-14 16:35:04	5	3	4	2	0	7	0	74.60	39	8.58	CHANGED	PtLolsuPttLoTADSAsssVpGTTsAAKVYVSVNGshhEAPlT...DG..TFSlDlALsusKNpVTVAAVuuDGGTAVEsRTVLaYGS	...PuLTVpu.sshSsssStTspVSGTTNAuKVhssVNGptTEhPVo...pG..oausDLsLstscN+VTlsAsGucGuoAopcRTlhtYG.......	0	0	0	0
+8969	PF09137	Glucodextran_N		Glucodextranase, domain N	Sammut SJ	anon	pdb_1ug9	Domain	Members of this family, which are uniquely found in bacterial and archaeal glucoamylases and glucodextranases, adopt a structure consisting of 17 antiparallel beta-strands. These beta-strands are divided into two beta-sheets, and one of the beta-sheets is wrapped by an extended polypeptide, which appears to stabilise the domain. Members of this family are mainly concerned with catalytic activity, hydrolysing alpha-1,6-glucosidic linkages of dextran to release beta-D-glucose from the non-reducing end via an inverting reaction mechanism [1].	19.50	19.50	19.70	20.50	18.00	19.20	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.66	0.70	-5.16	14	171	2009-01-15 18:05:59	2006-08-14 16:38:33	6	8	150	6	82	181	17	265.40	31	32.85	CHANGED	AsGuPGtsssWu.usKpGVGTu..............ssssSKVWFTlucGlloEVYYPpIDpAph+-LpFlVsc.GpsFhs-EpcDTtScl-hhs......stohuY+lsssDppGRYpIpKcIFTDPcRsullh+VpFpALcG...tDaplYlLhcPHlsNsGusssuals.cuput.sLhAptssshhALsuShsats......sSsGaVGsSDGhoDLt...tssphshpassAsp...GNlu.sucIsL.stspT..pFslsLGFGpotpEAspsAtuoLpsuasphhppY.s.....sWccYhsSL	...................................................A.GuPGtss..pWs..usKsGlGTu..................hsssS+VWFTl.ucG.lloElaYPplDpspl+-.lpFlV..ss...GpsFh.........spE+css....p....pplchhs.............sts.uac.ls...sp.s....tp...G+...aplpKclhoDPp+ssllh+lpFpu.hps.......shphYhlhsP+lsNsG.......t.......s..............spuhs.....p.....h...........tut.t...s..........Lh.A.pp............s..................sthhuLtu......sh.....s.....att.....................sSsGal.G.s.......SDGhpDLt......pstph...sh.p..aspAss............GNVuhsuplsh.......tsps......phslsLGFGpotp..p..A..hssAtuoLsp.u..apshhppYts.....sWcsahtsL.............................................	0	29	53	71
+8970	PF09138	Urm1		Urm1 (Ubiquitin related modifier)	Mistry J, Wood V	anon	Pfam-B_16507 (release 20.0)	Family	Urm1 is a ubiquitin related protein that modifies proteins in the yeast ubiquitin-like pathway urmylation [1]. Structural comparisons and phylogenetic analysis of the ubiquitin superfamily has indicated that Urm1 has the most conserved structural and sequence features of the common ancestor of the entire superfamily [2].	21.00	21.00	21.00	21.30	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.19	0.72	-3.87	29	304	2012-10-03 10:59:06	2006-08-14 17:07:09	6	2	274	6	211	350	18	94.70	42	89.71	CHANGED	clplEFhGGLElLhs.sp+paplsls.......sppthshpsLltalcpNlIp-.Rs.-lF..........................l.p.ssolRPGILVLINDsDWELhGph-YhLc-sDslsFlSTLHGG	.........................................lplEFsGGhEhLFs..s.+pHplsls.....................t.tp.hslppLlpalpcNllp-.....Rs..-LF..................................................................lp...ssoVRP.GILVLINDsDWE.L...G..c.-Y.Lpss.DslhFlSTLHGG........................	1	72	114	175
+8971	PF09139	Mmp37		Mitochondrial matrix Mmp37	Mistry J, Wood V	anon	Pfam-B_15301 (release 20.0)	Family	MMp37 is a mitochondrial matrix protein that functions in the translocation of proteins across the mitochondrial inner membrane [1]. It has been shown that MMP37 proteins possess the NTase fold but they have only one active site carboxylate and thus probably are not able to carry out enzymatic reaction. These potentially non-active members of NTase fold superfamily may bind ATP, hydrolysis of which is necessary for the translocation of proteins through the membrane [2].	21.10	21.10	21.80	21.80	19.20	19.00	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.34	0.70	-5.41	24	355	2012-10-02 22:47:23	2006-08-14 17:14:10	6	8	272	0	247	347	4	275.80	34	80.49	CHANGED	tL+pllspF.ss.lcaAFAYGSGVapQsG................t........tt.pttMlDhIFuVscspcaHohNLcQN.cHYSs..L+hhGschloplQsphGAGVYFNsalslN.....GphIKYGVVShcsLhcDLtpWcoLYlAGRLpKPV..clLp.c...csplchssphNL+SAlpsALLLL.......PppFoEhpLYppIuGLSYhGDhRM.lsG.EsPpKVpNIVpsphsp..F+cLYtPllps....................h.phsh.s..t..............phtpDhss.sphshlttLPp.shppplhhphpp.h..........................ptppst.h.hplutDs..ph.tpslppslpphlphsShsQolKGlhTAGlt+SlpYuhtKhpK	.............................h.hptlh.pF....lph..sFuYGSGVh.Qts...............................................ttpttMlDhlhsV....sps...pWHshNlppp.pHYSh......l.t..hh..G....st.hlsp.....lQp...h.G..AG.VYaNs.hl.hs..........uphl..KYGVlshcsLhpDLhpWpsLYlAGRLpKPV...cl..l.p...s...............ssplp....hs...phNLhuAlps....AlLhL....................................PtpF..o....E.pLatpIsuLSYh.GDhR..M...lhu.Es.pKVpNIVp..sp..htp..FcpLYt.sllpp.........................h.ph.h.........................thhh.t..D.hs.s.tphp.l.tLPt.phpppl.h.ht.........................................................................t.h.......p..l..u..tp....ph..tp.lppslpphlhhsShhQohKGlhoAGhh+ohtY..tKh.K......................................................................	0	80	139	203
+8972	PF09140	MipZ		ATPase MipZ	Mistry J, Thanbichler M	anon	Pfam-B_23525 (release 20.0)	Family	MipZ is an ATPase that forms a complex with the chromosome partitioning protein ParB near the chromosomal origin of replication [1].  It is responsible for the temporal and spatial regulation of FtsZ ring formation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.76	0.70	-5.31	12	431	2012-10-05 12:31:09	2006-08-14 17:22:01	6	7	400	5	138	13620	5467	180.40	27	57.60	CHANGED	HlIVlGNEKGGoGKSTsulHlAlALhttGh+VusIDLDhRQ+ohsRYhcNRsthtc+p.GlsLPhPpah........pl.cs-ssp..phpthhschptstDFIllDTPGscohLuRhAHohADTLVTPlNDSFVDFDllupVDPcThclptPShYuEhVW-uRptRAps....sttshDWlVlRNRLuthpuRN+p+lspuLp-LS+RlGFRlhsGhuERVIYRELFPpGLTLL.Dlpchsh..chshSHlsARQELRsLltuLsLPh	.............................................................................llsV..u..s.tKGGsGKST.lo..h....p...........L.A..l.....A....L...s.......+.....h.....G.......h....+.....VG.l........l.D...............sD...............l..............h.................t.................................S..................l..................s..................p................h....................h..............t...................s...................+..................t...................h....................h.....................................t...................p....................p....................................h......................................l............................................h....................................t............h....................h..........................................l........................................................................................................................h.........................................................t.............................................h.......................................................................h............p......t.....h...h......t.......p.........h..........t.............p.......h....D......a..lllD..h.P...s......................................................................................................................................................................................................................................................................................................................................................th............................................................................................................................................................................	0	46	90	114
+8973	PF09141	Talin_middle		Talin, middle domain	Sammut SJ	anon	pdb_1sj7	Domain	Members of this family adopt a structure consisting of five alpha helices that fold into a bundle. They contain a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin [1].	25.00	25.00	35.30	25.20	24.90	23.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.71	0.71	-4.56	6	194	2009-09-11 14:56:09	2006-08-15 09:39:34	5	31	87	6	108	161	0	157.90	59	6.87	CHANGED	sQpALhGoIsuuhcAVppA-c-Lcshss..lPsLGsDhuShpW+cNplDsSKpsVsS+lAAhoAuTApVVphTAu-PsDsDasAVGsAVosIouNLsElSKsV+LlAALM-c-s.sGccLL-AARsLsuAFSDLLKuApPpS...cEPRQsLLsAAGpVGpuSucLL	.................................AQQALhGTINoSMpAVQtAQssLs....-h-s...LP.PLGpDhAS+...sWhpNKhDESKHEIHSQVDAITAGTASVV...........NLTA..G.DP......s-TDYTAVGCAlTTISSNLTEMSKGVKLLAAL..M-D-s...GsGcsLLpAA+sLAGAVSDLL+u.spPsS.........................uEPRQslLsAAGslGQASG-LL......................	0	33	42	70
+8974	PF09142	TruB_C		tRNA Pseudouridine synthase II, C terminal	Sammut SJ	anon	pdb_1sgv	Domain	The C terminal domain of tRNA Pseudouridine synthase II adopts a PUA (Pfam:PF01472) fold, with a four-stranded mixed beta-sheet flanked by one alpha-helix on each side. It allows for binding of the enzyme to RNA, as well as stabilisation of the RNA molecule [1].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.31	0.72	-4.32	34	629	2012-10-02 17:37:24	2006-08-15 10:01:30	6	7	616	2	142	459	81	55.70	33	18.30	CHANGED	FsthclossEApslsaG+tLsss....uhsGshAAhsPDGcllALl...c-putcs+slsVht	......................................hshhplTscEAstlphGRhlphs....................shst.h.hA.Ahs.s.cG+......llAll........cc..cGsp....h+sltVh................	0	43	99	129
+8975	PF09143	AvrPphF-ORF-2		AvrPphF-ORF-2	Sammut SJ	anon	pdb_1s21	Domain	Members of this family of plant pathogenic proteins adopt an elongated structure somewhat reminiscent of a mushroom that can be divided into 'stalk' and 'head' subdomains. The stalk subdomain is composed of the N-terminal helix (alpha1) and beta strands beta3-beta4. An antiparallel beta sheet (beta5, beta7-beta8) forms the base of the head subdomain that interacts with the stalk. A pair of twisted antiparallel beta sheets (beta1 and beta6; beta2 and beta9/9') supported by alpha2 form the dome of the head. The head subdomain possesses weak structural similarity with the catalytic portion of a number of ADP-ribosyltransferase toxins [1].	25.00	25.00	28.70	28.20	24.50	23.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.05	0.71	-4.55	4	50	2009-01-15 18:05:59	2006-08-15 10:31:42	5	1	47	1	4	43	1	156.10	48	71.89	CHANGED	SpalGt.TLTSIHQLSsspREpFLssHDPMRshsLss-TslYRTTppRYl....+psKLAGNPpShAhlthHEELp.ss.hAS+..hGuhPcpAc.........AYhP+ph+AsDLssPSLNVMsGstAcsulRuYA+..sDHVsVcMRLGDFL-pGGKVYuDTSuhusGGDpspALIVTLPKGpKVPVcIl	................hstpshul................................F+I++DhVsVRIpsspFsD..hKNcKIpGHpNTVASVhDaYs.QcNu.Lu.s..hGosc+.oAD.........hh+.c++sAhNhhlhphNs.hap......s......us-Nht+SYuK.T-DsshVuholGsLLDKG.uKVYsDTSsulc...LuEPhIhTLPEus+VsV-I.............................	0	0	1	3
+8976	PF09144	YpM		Yersinia pseudotuberculosis mitogen	Sammut SJ	anon	pdb_1pm4	Domain	Members of this family of Yersinia pseudotuberculosis mitogens adopt a sandwich structure consisting of nine strands in two beta sheets, in a jelly-roll topology. As with other superantigens, they are able to excessively activate T cells by binding to the T cell receptor [1].	25.00	25.00	205.40	205.20	19.30	18.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-4.14	2	4	2009-01-15 18:05:59	2006-08-15 10:43:22	5	1	2	4	0	5	0	116.80	90	77.45	CHANGED	IPNIATYTGTIQGKGEVCIIGNKEGKTRGGELYAVLaSTNVNADMTLILLRNVGGNGWGEIKRNDIDKPLKYEDYYTSGLSWIWKIKNNSSETSNYSLDATVHDDKEDSDVLTKCPV	IPNIATYTGTIQGKGEVCIIGNKEGKTRGGELYAVL+STNVNADMTLILLRNVGGNGWGEIKRNDIDKPLKYEDYYTSG.LSWIWKIKNNSSETSNYSLDATVHDDKEDSDVLTKCPV	0	0	0	0
+8977	PF09145	Ubiq-assoc		Ubiquitin-associated	Sammut SJ	anon	pdb_1pgy	Domain	Ubiquitin associated domains contain approximately 40 residues and bind ubiquitin noncovalently. They adopt a secondary structure consisting of three alpha-helices, and have been identified in various modular proteins involved in protein trafficking, clathrin assembly/disassembly, DNA repair, proteasomal degradation, and cell cycle regulation [1].	20.20	20.20	20.30	56.80	18.60	16.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.22	0.72	-4.10	4	19	2009-01-15 18:05:59	2006-08-15 11:59:10	5	4	19	1	13	20	0	45.50	60	6.90	CHANGED	llDEV+DMElA+LMSLGLsI-cAscYY-+GlpYE...-.L+pR+pc	lVDEVKDMEIARLMSLGLSI-cAs-aYEpslhYEphl-hlKp+pt.....	0	1	6	12
+8979	PF09147	DUF1933		Domain of unknown function (DUF1933)	Sammut SJ	anon	pdb_1q15	Domain	Members of this family are predominantly found in carbapenam synthetase, and are composed of two antiparallel six-stranded beta-sheets that form a sandwich, flanked on each side by two alpha-helices. Their exact function has not, as yet, been determined [1].	20.50	20.50	20.50	20.60	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.24	0.71	-4.89	3	6	2012-10-03 21:14:07	2006-08-15 13:47:08	5	2	6	8	4	26	83	199.20	38	44.24	CHANGED	N-FClV+tGhDKDINpLt+-FsGphEtLSNGsLFhcpsT+VQKa+hERGTAYLIGSLYN+ohLRuLAG+aEGcusVlNDAEILhLlpT+LGuuALuLAEGDFCFFIED+NGsLTVITESRGhNPVaLVQucctWITNSLKLVoAlEG-tAhDFccEupVscoul+sDsaoPl+NlQRLKPGTlNVLTFDspcYpalESRpL	...............................spFChl+tuhsKNlsplhpsF.shph-pLSsGpLahpspophpKhcs-+tTAYLI..GoIYN+shLculAG+aEGcu..VlsDsElLhhlhs+LGsuALoLAEGDFCF.FI.E-Kp.G.pLpllT-SpGhssVaLVp...sc.h.hWI.TN.oLKlVu..t.lEG-tAhDFpsEu..pVhpssL..+..sDsaoPl+NspRLKPGolNhLoaDppcY.alEsc.l.......................................................	0	0	2	3
+8980	PF09148	DUF1934		Domain of unknown function (DUF1934)	Sammut SJ	anon	pdb_1r0u	Domain	Members of this family are found in a set of hypothetical bacterial proteins. Their precise function has not, as yet, been defined.	21.40	21.40	21.50	22.20	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.32	0.71	-4.43	66	1332	2009-09-10 22:25:01	2006-08-15 13:52:04	5	1	1317	1	164	708	2	126.10	26	91.48	CHANGED	l......pIphpphh..........tpsc.p-slEhhspGpahpKs.sshYlhYcEp..p.ss...sspsslKl..pcscltlhR...tGssph+hh.FppsccshshYpTPhGphpltspTpplplshs-ps...GplplcYpLh....hspphhuphplpl	..................................hpIphpshl.......p..tssc..pEph-.hhhp...Gphhp.+s.stpYlpYpEp..p.tt....phplslKl....pcpplhlhR...tGs.sphph+.Fhc.sp.c.shs.hYs.TP.hG.h.hpltspTppl..p.h.phpct.........tplpl.....cYpLh....tssphhusYplcl......................	0	64	110	138
+8981	PF09149	DUF1935		Domain of unknown function (DUF1935)	Sammut SJ	anon	pdb_1r75	Domain	Members of this family are found in various bacterial and eukaryotic hypothetical proteins, as well as in the cysteine protease calpain. Their exact function has not, as yet, been defined.	20.90	20.90	20.90	25.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.35	0.72	-4.05	71	300	2009-01-15 18:05:59	2006-08-15 14:02:30	5	8	15	2	76	289	0	104.30	31	23.51	CHANGED	ppGp...Ps...hp....sclhpsFcp...........G.........LLFRlVs.p................cppp..WuFYNDTpcaphcVpspFutsSp.l....csLssT..plt.........ppssGp........hhsplsVhPhcTphFl.cGps.sGacs.phpAhs	............................................GtPs.....hp.......sclhpsFcp...........G..........LLaRlls.p......................cppp....WuFYNDTpsaphcVpspFutsSp.l........pslssT..plp...............ppssGp...............hhsplsVhPhcTphFl.cGps.sGapsphpA.................	0	38	56	76
+8982	PF09150	Carot_N		Orange carotenoid protein, N-terminal 	Sammut SJ	anon	pdb_1m98	Domain	Members of this family adopt an alpha-helical structure consisting of two four-helix bundles. They are predominantly found in prokaryotic orange carotenoid protein, and carotenoid binding proteins [1].	25.00	25.00	64.60	64.60	23.40	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.90	0.71	-4.54	8	95	2009-01-15 18:05:59	2006-08-15 14:34:12	5	2	47	8	43	100	4	155.00	45	65.57	CHANGED	ThDsA...Fs.ohtussV.sllspFNpLss-DpLALlWFsYpEMG+oITsAAPGAA..shpLAEuhLsplptho.cE.QhplMpDLss+sDTPloRsYGsaSsNsKLsFWYpLuEhMcQGsVsPlPsGYQLSssANplLEsIKsLDhGQQITlLRshVlsMGaDs	..............s............s..usslssshspFppLos-DQLALlWFuYhEMGcoITsAAPGAA..phphA-shLspI+pMo.pE.QhplMpDLAs+s-...Tsl.oRsYushSsNsKLuFWYpLuchMcpGhVsPlPsuYpLSssAsslLpsIcsL-.uQQITlLRssVs-MGhDs...........	0	5	27	42
+8983	PF09151	DUF1936		Domain of unknown function (DUF1936)	Sammut SJ	anon	pdb_1pvm	Domain	This domain is found in a set of hypothetical Archaeal proteins. Its exact function has not, as yet, been defined. It possesses a zinc ribbon fold.	25.00	25.00	98.90	98.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.81	0.72	-4.45	2	2	2012-10-03 10:42:43	2006-08-15 15:04:02	5	1	2	4	2	5	1	36.00	89	20.45	CHANGED	pHLCPKCGVGVL.PVYspKGEIKVFRCSNPACDYEE	pHLCPKCGVGVL.PVYspKGEIKVFRCSNPACDYEE	0	1	1	1
+8984	PF09152	DUF1937		Domain of unknown function (DUF1937)	Sammut SJ	anon	pdb_1t1j	Domain	This domain is found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been described.	23.00	23.00	23.00	23.40	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.41	0.71	-3.52	7	46	2012-10-02 19:28:18	2006-08-15 16:31:34	5	1	35	2	10	39	1	111.80	41	80.93	CHANGED	RhlaLAsPYS........+.stshlptphhssschAApllcsGhssaS.VohS....HPI.hshs.h.cst.stlWushst.ahchhptllVl-lsGWccSsGI++Elchatstsp.V.laup	..R.laLAsPYS........+sss-hsEtphtssschsAp....llc.sGhsshS.VshS....Hsh.hshh..h.csh.stLWtshst.hhcth.ptllVh-lsGWccSsGIR+ElchhpAtsh.V.lau........	0	7	7	10
+8985	PF09153	DUF1938		Domain of unknown function (DUF1938)	Sammut SJ	anon	pdb_1mgt	Domain	Members of this family, which are predominantly found in the archaeal protein O6-alkylguanine-DNA alkyltransferase, adopt a secondary structure consisting of a three stranded antiparallel beta-sheet and three alpha helices. Their exact function has not, as yet, been defined, though it has been postulated that they confer thermostability to the archaeal protein [1].	22.10	22.10	24.80	94.00	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.65	0.72	-4.17	4	13	2009-01-15 18:05:59	2006-08-16 09:16:18	5	1	13	1	11	16	0	86.00	45	49.32	CHANGED	MLoscpF+ltsRtlhIGVlaE-+IQGIsaSlDthEhl+cplscLhsaLpKR.GVplsLcEppScYP-lVFcVLhGKIuNEcuhE..ELS	MLSlE+FcIssR-lhIuVla-cK.IQGIoFSLDGtEFLccRIssLspaLc+R.GVsVsLcpccScYP-LVacVLlGclcNE-uLc..ELS.	0	1	1	6
+8986	PF09154	DUF1939		Domain of unknown function (DUF1939)	Sammut SJ	anon	pdb_1mxg	Domain	Members of this family, which are predominantly found in Archaeal amylase, adopt a secondary structure consisting of an eight-stranded antiparallel beta-sheet containing a Greek key motif. Their exact function has not, as yet, been determined [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.73	0.72	-4.07	9	520	2012-10-02 20:10:03	2006-08-16 09:30:45	5	6	490	22	62	384	5	58.10	47	11.92	CHANGED	LlVhI.Npussh+p+hVpT.sWsspslhDYoGNuu...sssossDGWVplpsPsp.......GYulaS	............hu..lhl.sNsp.t.sS.K.pMaVGp..c.a.s.spsFhD..lLGNpp.........spVTI---GaGpFsVuup.........SVSVWs.	0	18	31	47
+8987	PF09155	DUF1940		Domain of unknown function (DUF1940)	Sammut SJ	anon	pdb_1nig	Domain	Members of this family adopt a secondary structure consisting of six alpha helices, with four long helices (alpha1, alpha2, alpha5, alpha6) form a left-handed, antiparallel alpha helical bundle. The function of this family of Archaeal hypothetical proteins has not, as yet, been defined [1].	25.00	25.00	252.60	252.50	23.20	18.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.83	0.71	-4.35	3	3	2009-01-15 18:05:59	2006-08-16 09:46:44	5	1	3	1	3	4	4	143.00	47	93.87	CHANGED	YCPVIDDpLPlDHVYFKFRSEIEuAEAFLGLAVSEGlKVsETRElLDILDTVYNSLYDcESKLNDFQEKRLNFTEE-WYDIKEKsNNGNKWSLYMFLARSHlDsAVYWlo+M+EDERFK-hVcDEsIstLLKlGhVILREGLG	YCPVIDDpLPlDHVYFKFRSEIEuAEAFLGLAVSEGlKVsETRElLDILDTVYNSLYDcESKLNDFQEKRLNFTEE-WYDIKEKsNNGNKWSLYMFLARSHlDsAVYWlo+M+EDERFK-hVcDEsIstLLKlGhVILREGLG	0	1	2	2
+8988	PF09156	Anthrax-tox_M		Anthrax toxin lethal factor, middle domain	Sammut SJ	anon	pdb_1j7n	Domain	Members of this family, which are predominantly found in anthrax toxin lethal factor, adopt a structure consisting of a core of antiparallel beta sheets and alpha helices. They form a long deep groove within the protein that anchors the 16-residue N-terminal tail of MAPKK-2 before cleavage. It has been noted that this domain resembles the ADP-ribosylating toxin from Bacillus cereus, but the active site has been modified to augment substrate recognition [1].	83.00	83.00	108.40	108.30	82.90	82.90	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.06	0.70	-5.30	2	16	2009-01-15 18:05:59	2006-08-17 09:03:18	5	3	14	17	1	17	0	259.30	97	36.03	CHANGED	MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV	MLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVV...	0	0	1	1
+8989	PF09157	TruB-C_2		Pseudouridine synthase II TruB, C-terminal	Sammut SJ	anon	pdb_1k8w	Domain	Members of this family adopt a secondary structure consisting of a four-stranded beta sheet and one alpha helix. They are predominantly RNA-binding domains, mostly found in Pseudouridine synthase II TruB [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.78	0.72	-4.11	98	1516	2012-10-02 17:37:24	2006-08-17 09:13:28	6	5	1503	3	305	983	305	58.00	38	18.73	CHANGED	PplpLsspputtlhpGQsV...............sssst..pG.hVRla......spstp..FlGlGclstcG...hltP+RLl	.........PhVsLs.ss.ushhppGpsV........h................s.ss.sPh..cG..hVRVh........ucss+....FlGlGE.l...sc.-.G......+luP+RLl.................	0	68	161	235
+8990	PF09158	MotCF		Bacteriophage T4 MotA, C-terminal	Sammut SJ	anon	pdb_1kaf	Domain	Members of this family adopt a compact alpha/beta structure comprising three alpha-helices and six beta-strands in the order: alpha1-beta1-beta2-beta3-beta4-alpha2-beta5-beta6-alpha3. The beta-strands form a single anti-parallel beta-sheet and the three alpha-helices pack side-by-side onto one surface of the beta-sheet. In this architecture, the domain's hydrophobic core is at the sheet-helix interface, and the second surface of the beta-sheet is completely exposed. The domain is a DNA-binding motif, with a consensus sequence containing nine base pairs (5'-TTTGCTTTA-3'), that appears to bind to various mot boxes, allowing access to the minor groove towards the 5'-end of this sequence and the major groove towards the 3'-end [1].	25.00	25.00	57.50	55.90	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.37	0.72	-4.34	3	25	2009-01-15 18:05:59	2006-08-17 09:29:02	5	2	24	6	0	22	0	102.40	43	49.29	CHANGED	ITuEMcELt-hlhcLl--N.lsLKcVEIYRSNYplIFuKRT.pGIRpFEIpNNGshRIFGYKMuEc+lctFTslGs-lKIthGGpNTYIDIcpsucNItsVlTlA	....ITs-MEp.tDhhhcLL..--p.hs.lKclpp.RSNallhhpKRT.cGIRpFElpNsGphRIFGYKMtE+clppFTslGhssKlttsG.NsYlDIcpos-NIttlIssA...	1	0	0	0
+8991	PF09159	Ydc2-catalyt		Mitochondrial resolvase Ydc2 / RNA splicing MRS1	Sammut SJ	anon	pdb_1kcf	Domain	Members of this family adopt a secondary structure consisting of two beta sheets and one alpha helix, arranged as a beta-alpha-beta motif.  Each beta sheet has five strands, arranged in a 32145 order, with the second strand being antiparallel to the rest. Mitochondrial resolvase Ydc2 is capable of resolving Holliday junctions and cleaves DNA after 5'-CT-3' and 5'-TT-3' sequences [1].  This family also contains the mitochondrial RNA-splicing protein MRS1 which is involved in the excision of group I introns [2-3].	20.00	20.00	20.00	20.70	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.92	0.70	-4.91	53	128	2012-10-03 01:22:09	2006-08-17 10:06:20	5	6	108	2	83	123	59	264.70	23	72.90	CHANGED	I....LSIDhGl+NhAascLps..........................shtssppshP............................pLpsWp....+lsLs.............................................................................pttstppccpp.shsPshhuphAasLlspLl.tshp.....P...shllIERQRhRSsGuuul.EhsL+VsllEsMLaAsLpshppppptt.st..............hVhussPp+lspaWhpttsh.........ps......................tpppphssppsKph+IcLltphLsssh........................hthshsts.ph....h...pthlt+apsptpsppthtthtt...............................................tt.chpKlDDLADsLLpu.lsWhcWppsppcl	.............................ILSIDhGl+NhAasplph................................tttpshs.............................................................................pltsWp....+lsLp.......................................................................................................t.t...ppppp.shs.Pt.huphsapLlppLh..shp..........P.shllIE..R..QRhRosu.u......ssl.-.sl+VshlEshLaAsLpsh.t.ttp...t................hVhussPp+hspaWhp.t.........................................................ppphhssppsKph+lcLltphLpssh........................hth.h..tt.ph............thhtt.attthptththtth.t.................................tt..phtKhDDLsDslLpu.lsWhcW.tthpp..................................................................	0	18	40	69
+8992	PF09160	FimH_man-bind		FimH, mannose binding	Sammut SJ	anon	pdb_1klf	Domain	Members of this family adopt a secondary structure consisting of a beta sandwich, with nine strands arranged in two sheets in a Greek key topology. They are predominantly found in bacterial mannose-specific adhesins, since they are capable of binding to D-mannose [1].	25.00	25.00	27.20	27.10	24.00	19.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.74	0.71	-4.36	6	806	2009-09-14 15:18:23	2006-08-17 10:27:01	5	4	326	37	14	375	0	143.80	68	49.23	CHANGED	C+sssTGQ.sh...suGsusVhVNLsPsVpsspNl.VlDLSQ...plsCpND.ushp.hDYlplppGSuFusuLss.......FoGolpahupoYPhPhssps.sphhhspssa+PhPlKhYLoPsuuAsGVlI+uG-LIAplhhpKhuohu.cus.+N.......FsWp	...............C+s.sGsu.sI....GGG....oA...NVY.VNLuPs.VNVGQN.L..VVDLST...QIFCHNDYPE.......TITDYVTL.QR.GSAY.GGVLSs.......FS.GTVKYsG.oSYPFPT.ToET.sRVlYsSRTDKPWPlsLYLTP....VS.o..AGG.VsIKAGSLIAVLIL+QTNNY.....NSD-FQ.......FlWN...........................	0	2	4	9
+8994	PF09162	Tap-RNA_bind		Tap, RNA-binding	Sammut SJ	anon	pdb_1koh	Domain	Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element [1].	20.80	20.80	21.60	21.50	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.86	0.72	-4.41	12	238	2009-01-15 18:05:59	2006-08-17 10:39:35	5	15	77	12	138	237	0	85.00	43	15.68	CHANGED	Dtsp..csWFKlTIPaG+KYDKpWLLs.lQshCSlPFsPVcFHh-pp+ApFFVEsussApALKplSt+IhDc-spKlsIhhsPsssP.pl	.............tsWFKl.TIPaGpKYDKpWLls..I.Qu.p.CSVPFsPl..........-.FHY-ps.c.ApFFV-DussAsALKslshKI.hD.c.-.sp+IsIhVs.sussP..................	0	21	29	62
+8995	PF09163	Form-deh_trans		Formate dehydrogenase N, transmembrane	Sammut SJ	anon	pdb_1kqf	Domain	Members of this family are predominantly found in the beta subunit of formate dehydrogenase, and consist of a single transmembrane helix. They act as a transmembrane anchor, and allow for conduction of electrons within the protein [1].	20.60	20.60	20.90	20.90	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-7.95	0.72	-4.46	40	1298	2009-01-15 18:05:59	2006-08-17 10:52:16	6	17	834	2	134	480	11	44.10	58	14.80	CHANGED	ISssVpLWK.GlhKPLushuhuussluuhhHYlslGPNcss....----	..IspoVphWK.GhhKPLAAsGFhATF..AutIFHYlGlGPN+ts....----p.......	0	20	52	94
+8996	PF09164	VitD-bind_III		Vitamin D binding protein, domain III	Sammut SJ	anon	pdb_1kxp	Domain	Members of this family are predominantly found in Vitamin D binding protein, and adopt a multihelical structure. They are required for formation of an actin 'clamp', allowing the protein to bind to actin [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.39	0.72	-4.36	6	46	2012-10-01 21:15:37	2006-08-17 11:02:52	5	2	31	9	23	56	0	67.30	58	14.43	CHANGED	ELCADYSENTFTEYKKKLu-pLRsKhP-Aosp-Ls-LVsKRSDFASpCCSINSPPlYCsSpIDAElps	.....................ELCADYSENTFTEYKKKLuEpL+sKhPDAoss-LtcLV-+RSDFASpCCSINSPPLYCsSplcs.ht............	0	1	2	6
+8997	PF09165	Ubiq-Cytc-red_N		Ubiquinol-cytochrome c reductase 8 kDa, N-terminal	Sammut SJ	anon	pdb_1l0l	Domain	Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain [1].	22.90	22.90	23.70	22.90	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.42	0.72	-3.66	16	86	2009-09-11 00:16:57	2006-08-17 11:15:50	5	2	67	47	31	89	0	73.30	47	27.43	CHANGED	hSlsuRSGsluPYlpATopuVAusLK.PLlPusl.hpuEKlllcs++shLs+ESLsGphPppuLtsosu.lsususVR	........hSlAARSGsFAPhLpATSpuVAGsL+.P.LltusV....sssEpslLDsK+PFLsRESLSGQus+p.sLsASVG.lNsPAoVR.......	0	9	12	18
+8998	PF09166	Biliv-reduc_cat		Biliverdin reductase, catalytic	Sammut SJ	anon	pdb_1lc0	Domain	Members of this family adopt a structure consisting of four alpha helices and six beta sheets, in an alpha-beta-alpha-alpha-alpha-beta-beta-beta-beta-beta arrangement. They contain a catalytic active site, capable of reducing the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor [1].	21.00	21.00	21.00	23.40	19.20	20.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.43	0.71	-4.07	4	55	2009-01-15 18:05:59	2006-08-17 11:33:23	5	3	38	7	31	52	0	111.70	61	38.98	CHANGED	-FKtLK+ElpGKpL.EGsLHFTGGPLcts.FGFPuFSGIARLTWLVsLFG-LoVTSAThEEcKEppY.KMTApLhTppc+PLTWIEERGPGhtRsKHIcF+FpssoLsplPuusR	................................EFthLKKEVsGK-LlKGoLhF.TuGPL-Ep+FGFPAFSGIuRLTWLVsLFGELSlsSATLEEcKEcpYhKMTVpLcTpsK+PLTWIEE+GPGLKRs+alsF+FcSGoLEslPsss.h.............	1	2	3	10
+8999	PF09167	DUF1942		Domain of unknown function (DUF1942)	Sammut SJ	anon	pdb_1lmi	Domain	Members of this family of bacterial proteins assume a beta-sandwich structure consisting of two antiparallel beta-sheets similar to an immunoglobulin-like fold, with an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of these beta-strands form an antiparallel beta-sheet. The exact function of this family of proteins is unkown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation [1].	20.70	20.70	20.80	23.30	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.59	0.71	-4.38	13	123	2009-01-15 18:05:59	2006-08-17 11:45:15	6	2	76	1	32	109	0	122.70	51	64.17	CHANGED	ApssspplGpsucLls..GsVVQsWTVSDLKPSoDsIP.YtltGpLWEATATscAlsGsVTPIVSNhNARAssGpoYRVLapVATPpGlNPuTLuQGppoTGKlYFDV.TGssPsSVVY.NsGupDlllW	....................s..PhstphGophphsD..ssGtVV.uWpVSDL+sSossIP.YsltGplWEATATspAlpGoVTPsVupFNARsssG.sYRVLap.sAsPsslssATlsQGppoTGKIYFDV.TGssPshVsh.NsG..hpDLLlW........	0	1	18	27
+9000	PF09168	PepX_N		X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal	Sammut SJ	anon	pdb_1lns	Domain	Members of this family adopt a secondary structure consisting of a helical bundle of eight alpha helices and three beta strands, the last alpha helix connecting to the first strand of the catalytic domain. The first strand of the N-terminus also forms a small parallel beta sheet with strand 5' of catalytic domain. The domain mediates dimerisation of the protein, with two proline residues present in the domain being critical for interaction [1].	25.00	25.00	28.60	28.50	21.30	19.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.07	0.71	-3.98	24	510	2009-01-15 18:05:59	2006-08-17 11:56:45	5	3	489	1	52	340	1	141.70	47	19.29	CHANGED	MKhN..QFualssshcpthpELppluF....hptpss.ps.LcsFlp+hahphps...psttLsplhAsscpDLhsFhpoc.pplotclFYslALQLLGFpsthDFsh.DshshhcchshP.......hhssppllpuhYpLLsTRoKsGpoLlDpLsucGa	...M+aN..QaSYlshsh-phlpELcplGFp...hpspsstKcsLEsFLR+hFhpaps....osasLo.LAA-pcTDLLoFFpS-.pcLTs-lFYsVAhQLLGFphhVDF-..DspsFh+csuFP......hhasp..LI-sLYpLLNTRTKpGpTLIDpLVScGL.........	1	7	20	34
+9001	PF09169	BRCA-2_helical		BRCA2, helical	Sammut SJ	anon	pdb_1iyj	Domain	Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (Pfam:PF09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [1].	25.00	25.00	25.00	25.10	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.13	0.71	-4.74	5	134	2009-01-15 18:05:59	2006-08-17 12:55:12	5	28	95	3	83	142	1	148.40	43	7.01	CHANGED	DLhusLps......ARDlQ-MRIKKKpRQplhPQPGSLYLsKoSslsRISLKuAVGccsPStpSs...cQLYsYGVSK+CIcVNScNAESFQFclp-FFuK.EsLpsGcGIQLADGG..WLIPoNDGKAGKEEFYRALCDTPGVDPKLISctWVYNHYRWIVWKLAAMEpuFP+cFANRCLTPEpVLLQLKYRYDlEIDpS	....................................................................................................................................................................h.t...............h............ph..htl..t.....h.tlpstsu....apF...paht.....t..h..........t.tuh.htDus.....hl.l.s.ppGp..s.Gt.cEFhcAlhsss...GVDPpLloctWVhNHYRWIlWKLAu..M..Eh.sFPc...c...h...us...+.sLoP-pVLhQLKYRYDhElDp.....................	0	36	46	64
+9002	PF09170	STN1_2	DUF1879;	CST, Suppressor of cdc thirteen homolog, complex subunit STN1	Mistry J, Sammut SJ	anon	pdb_1wj5	Domain	STN1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required for protecting telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity on their own. In addition to telomere protection, the CST complex probably has a more general role in DNA metabolism at non-telomeric sites.	21.90	21.90	24.90	24.20	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.27	0.71	-4.50	6	63	2009-01-15 18:05:59	2006-08-17 12:57:40	5	4	43	1	32	51	0	165.20	48	47.30	CHANGED	DPshslQIARMLELPplYRpVYDpPFchPsptcs..Eutsspt.ls.stLlShLSEKlKEFLhEp+lpsFYQpELE.hV-SLlulASpPV...ssuDQ.p.tcoSsSpQl+plFKEAlplLQ-cGhlFQKcpspDEVYpVTcQDKDLHptIhcII+EDC++pKHhEKGCHhLHILsCVRhs	.......DPshslQIARMLELPplYRclYDpPFp.sshtpp...cuhs.s.sss.lshssL.sshL.....SEKhK-FL..hE.s+VpoFY....QpELE.hV-SLlslAspPl........sssucQ...sh.ps.sosSptI+slFKpAlplLQ-cGlVFQKssu.Dpl.YaVTccDK-LH+pIhcIIpEDCQKPpHsEKGCHFLHILuCsR.p....................................	0	5	7	14
+9003	PF09171	DUF1886		Domain of unknown function (DUF1886)	Mistry J, Sammut SJ	anon	pdb_1xg7	Domain	This domain is predominantly found in the Archaeal protein N-glycosylase/DNA lyase.	21.30	21.30	21.60	21.30	19.80	21.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.58	0.70	-5.35	19	68	2009-01-15 18:05:59	2006-08-17 13:00:51	5	1	58	4	53	72	1	219.20	28	79.14	CHANGED	ls-hlpclul-tsphlEcp.DsQacAlppLhcph.spthhspLllhNALVSYpLou+GE-aWhpFucY......Fupp....pspslscsahpFLppSphN+RhlcsKl+Rlc+hpsalpsL.t..s...ha.pshstlhppLu+hLsuctpsKTlVFAlKMhsYAhRsshsh.hshPh-IPIPlDhRltplThp......................hpp-tshchWsplA+couIPPLHlDollW.lhGtsh.htp..tp..........ltcclttlhc	....................................................................................................................................hphlpplslchhphhEcp.D.QahslppLhpph..st..............thhhhLslhNuLlSYpLss+G.E.c.aW..Fuca.......aspp.............pshhctahp.Fl.po.htchhhptKl+Rlp+h..hsh.h...pl.....p...hh.pshtthhppLuphlssc.ptKTlVFAlKMhsY...uhchs.s..h....hsh-IsIPlDhRlsphThp..h...............................hppctshphWpplu+p.....u.s....IPPlHlDolLW.lhGtth..h.p.......................t...................	0	16	26	38
+9004	PF09172	DUF1943		Domain of unknown function (DUF1943)	Sammut SJ	anon	pdb_1lsh	Domain	Members of this family adopt a structure consisting of several large open beta-sheets. Their exact function has not, as yet, been determined [1].	23.10	23.10	23.60	23.20	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.78	0.70	-5.55	71	578	2009-01-15 18:05:59	2006-08-17 13:03:58	6	29	211	1	253	586	0	275.40	18	14.04	CHANGED	+aS+shchshassshhhGs...usps.hI.sssohLP+slhhphpshhhGt..shslhElGhRsEGlcchltc................................................................................ts...tpphpclpphlpt.lpph+shs.......ppsh.............ushYl+hhGpElsFhslsc.........phlcphhphh..............pphlpp.......lh.pGhphp..hs+shlhh-schhhPTshGlPhcluhhssul.suhpspsp.hslps.h.p.h..........pshphcschpPSluhphhuhhGlsss.hhps..ulphcsplpstsshchpsclshptt.phclph...ss..pp.pclhsh..p.scsasl	..................................................................paSpshp....hshh.p...h........hG....s....thph.hIhsssohlP+thhhphpt.hhGh..shshhEluh..cs..cuhcphltph.........................................................................................t....tp.....tpthpp.lt.p..hl...ph.hpphcth........ts..............up.h.al+hhGp-htahshsc.............phl.pph.hphh..................tphlpp...lh.....puhphp.......ht..p.hhhh-sphhh..PTshGlPhp.hshhsssl.sshp.s.p..sp..hphps...t...................tphphph..phpPohuhphhsh..hGh.ss..hhps....ulthpsph..pt.ths...hchphphpht....t..p.....hclph....ss....pp......pl..hph.psp.hh.................................................................................	0	84	117	208
+9005	PF09173	eIF2_C		Initiation factor eIF2 gamma, C terminal	Sammut SJ	anon	pdb_1kk1	Domain	Members of this family, which are found in the initiation factors eIF2 and EF-Tu, adopt a structure consisting of a beta barrel with Greek key topology. They are required for formation of the ternary complex with GTP and initiator tRNA [1].	22.00	22.00	23.10	23.40	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.95	0.72	-3.94	36	581	2009-09-10 18:26:08	2006-08-17 13:07:42	6	11	483	29	368	573	91	89.20	51	18.91	CHANGED	asclcl.paaLLcRllGs+p......thKVppLppsEsLMlNlGSsoTsGhVsulK..sDhsclpLspPVCsphG-.+lAlSRRlsp+WRLIGWGpI	..................asElEl.saaLL+RLLGV+ot...........stKtuKVpKLs+sElLMlNIGShoTGG+VsulK........sDh.A+l.tL.TsP.VCT-hGE.KlA.LSRRl-....KHWRLIGWGpI........	0	119	204	294
+9006	PF09174	Maf1		Maf1 regulator	Mistry J, Wood V	anon	manual	Family	Maf1 is a negative regulator of RNA polymerase III [1][2].  It targets the initiation factor TFIIIB [3].	21.60	21.60	23.00	23.50	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.08	0.71	-4.42	21	367	2009-01-15 18:05:59	2006-08-17 13:09:05	5	7	291	1	253	346	4	169.50	32	62.03	CHANGED	slhupl-saos+hstsc+plhpphppp.pttt.ps.s.s.....................t.........................sshsslscpsSR+sLsYLIusLNtsa.PD.YDFS.slcspsFp+p.ohppVhsplsssL.slspp.h............................shhtplWpslc-pls..lp-C-IYoYs..Pp.ssDPa.sEcGslWShsYFFaNKKhKRllahp	............................................................................................................................hhsth-.aosKhsus-+chh+ph..ppp..h..p..sp....p..p.s......................................................s......tt....t.t....................................................sshusL.s...pp.s.SR+ThhYLIuTLNtua.PD.YDFS.sh+s..pcF..............p+E.s...hphlhstlsssLh..shs.tp.........................................................................................................shhsphWpsl-cphs..Lp-...CslYoYs..P...s.sDPa..t-p.....G...s....lWShpYFFaN+chKRlsah......................................	1	94	148	216
+9007	PF09175	DUF1944		Domain of unknown function (DUF1944)	Sammut SJ	anon	pdb_1lsh	Domain	Members of this family adopt a structure consisting of several large open beta-sheets. Their exact function has not, as yet, been determined [1].	20.90	20.90	23.70	21.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.02	0.71	-4.62	30	201	2009-09-11 17:00:47	2006-08-17 13:15:43	5	9	70	1	58	162	0	155.20	37	12.32	CHANGED	PshsllsRAVRuDpKhtGYQlusYhD.+ssuR..lQlIluslu-ssNW+lCADuslLS+HK.lhA+luWGtEC+pYssplpAETGhl.GspPAsRl+lsWs+LPpsh+...cYuKtlscYl...sssAhhsGlspp+p+Nsp+QlplTlsssSp+olslllKsPchTlYKhultLP	...........................................................................PshsllhRAlRuDpKh.GYQlssYhDpssuR...lQllluslu-ssNWKlCADuslLSpHK....spA+lsWGtEC+.pYps.hpA.EoGhl.uppPAsRl+lpWp+lPphhp...phu+pltcal....ssAh.hGhp..p+scNsp+plplosAhsSp+olsllh+hPchTha+hslhLP......................................	0	0	11	41
+9008	PF09176	Mpt_N		Methylene-tetrahydromethanopterin dehydrogenase, N-terminal	Sammut SJ	anon	pdb_1lu9	Domain	Members of this family adopt a alpha-beta structure, with a core comprising three alpha/beta/alpha layers, in which each sheet contains four strands. They are predominantly found in prokaryotic methylene-tetrahydromethanopterin dehydrogenase, which catalyses the dehydrogenation of methylene-tetrahydromethanopterin and the reversible dehydrogenation of methylene-H(4)F [1].	19.10	19.10	21.30	24.80	17.80	15.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.70	0.72	-4.12	17	128	2009-01-15 18:05:59	2006-08-17 13:40:18	6	9	85	6	52	135	48	76.40	47	27.55	CHANGED	PFDlNMAlDAGa-slhsYusVp.p-VpsLVQDuIFSRuPpshp+TulFIGGpDhshAhshLcsAKcuhlPPFclSV..hsDPu	.PFDlshAhDAGh-hlhsYssVp.spVsuLsQDuIFoRuPpshtcTuIFIGG+DsthAhDMLcsA+cuhhsPFclSV..hADPu.	1	16	37	44
+9009	PF09177	Syntaxin-6_N		Syntaxin 6, N-terminal	Sammut SJ	anon	pdb_1lvf	Domain	Members of this family, which are found in the amino terminus of various SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that they regulate the SNARE motif, as well as mediate various protein-protein interactions involved in membrane-transport [1].	24.90	24.90	25.00	25.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.11	0.72	-3.58	43	417	2009-01-15 18:05:59	2006-08-17 14:06:41	6	8	263	7	271	389	2	95.20	29	35.74	CHANGED	DPFa.Vpc-Vpculsph....cslappatphhssss.................chtphpp-LpsslpslchsLcDLcculsl.....spps...Pp+a.slsppElscR+palpphcsplpplc	..............DPFa.....VppE.Vpculsph....culappahclhppss.....................t..Ehp.tppELcssLpolchsL.-DL-c.ol..pl...................scps.....Pt+.a.slstsElspR+palpshcpplpphc....................	0	80	146	214
+9010	PF09178	DUF1945		Domain of unknown function (DUF1945)	Sammut SJ	anon	pdb_1lwh	Domain	Members of this family, which are predominantly found in prokaryotic 4-alpha-glucanotransferase, adopt a structure composed of six antiparallel beta-strands, four of which form a beta-sheet and another two form a type I' beta-hairpin. The role of this family of domains, has not, as yet, been defined [1].	21.20	21.20	29.40	28.10	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.52	0.72	-4.08	2	9	2009-09-11 06:49:26	2006-08-17 14:23:45	5	1	8	4	2	8	2	49.40	71	11.17	CHANGED	AplEFLCKE-KhL.VYRLhD-t+SLKVhHNLSstEhVFEGV+hpPYpTEVl	.......AKlEFLCKE-KFL.VYRLYDDQ+SLKVFHNLSGEEVVFEGV+h+PYKTEVV.	0	1	1	2
+9011	PF09179	TilS	DUF1946; 	TilS substrate binding domain	Sammut SJ, Bateman A	anon	pdb_1ni5	Domain	This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.10	0.72	-3.96	123	1699	2009-01-15 18:05:59	2006-08-17 14:53:22	6	7	1681	3	357	1331	279	68.00	29	15.99	CHANGED	Lslss..Ltpho.scppplLRhWLpth...sh.thPoptpLpplhpplhtup...tDupsplph.s...shplRRapscLah	...........Lplss..hhshS.ss+pttllRtWLstt...sh..shP.......S..pspLpclhpplt.hA+...pDussplph.s......shplRRapspLah.............................	0	94	204	286
+9012	PF09180	ProRS-C_1		Prolyl-tRNA synthetase, C-terminal	Sammut SJ	anon	pdb_1nj1	Domain	Members of this family are predominantly found in prokaryotic prolyl-tRNA synthetase. They contain a zinc binding site, and adopt a structure consisting of alpha helices and antiparallel beta sheets arranged in 2 layers, in a beta-alpha-beta-alpha-beta motif [1].	20.90	20.90	21.10	21.00	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.60	0.72	-4.05	82	1277	2009-01-15 18:05:59	2006-08-17 15:23:59	6	39	1155	18	562	1221	419	73.60	33	12.63	CHANGED	a--h............ppsl.spt....shlhssWCGs.tcsEpcIKcco.....................sApshCl.Ph..-........p.tpsspCl...hsG.+sAp..phshFu+uY	............................................a--hpptl..pcs........salhu.WCGs..tcCE-cIK-co...........................................uAssRCI.Pa-.....................ttptsspCl.....hsG..+sAc..phshFu+uY..............	0	222	375	492
+9013	PF09181	ProRS-C_2		Prolyl-tRNA synthetase, C-terminal	Sammut SJ	anon	pdb_1nj8	Domain	Members of this family are predominantly found in prokaryotic prolyl-tRNA synthetase. They contain a zinc binding site, and adopt a structure consisting of alpha helices and antiparallel beta sheets arranged in 2 layers, in a beta-alpha-beta-alpha-beta motif [1].	25.00	25.00	78.40	77.10	19.50	17.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.08	0.72	-4.05	4	16	2009-01-15 18:05:59	2006-08-17 15:24:53	5	1	16	4	10	17	0	65.10	57	14.15	CHANGED	ITll-NhcsD......clKtsLSEpKGlILVPacEsIYNEEFEEhIDASVLGpTpYcGKcYISIA+TY	.........ITll.sh....-s-.....-clKphLsEp+GlILIPacEsIYNEEhEEpl-ASVLGpTpYcGKcYIuIA+TY	0	1	2	7
+9014	PF09182	PuR_N		Bacterial purine repressor, N-terminal	Sammut SJ	anon	pdb_1o57	Domain	The N-terminal domain of the bacterial purine repressor PuR is a winged-helix domain, a subdivision of the HTH structural family. It consists of a canonical arrangement of secondary structures: a1-b1-a2-T-a3-b2-W-b3, where a2-T-a3 is the HTH motif, a3 is the recognition helix, and W is the wing. The domain allows for recognition of a conserved CGAA sequence in the centre of a DNA PurBox, resulting in binding to the major groove of DNA [1].	24.60	24.60	24.80	24.60	24.50	23.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.21	0.72	-4.36	37	1165	2012-10-04 14:01:12	2006-08-17 15:54:53	5	2	1161	8	145	506	0	68.50	57	25.17	CHANGED	+Rs-RllshT+hLl-pPpcLlsLshFu-hapuAKSoISEDLsIlKcshcchuhGpl-TlsGAAGGV+YIP	.....+RS-RhVshopYLlspPpcLlsLshFA-+YpuAKSSISEDlsIIKcsFccpplGplpTlsGAuGGVpahP....	0	52	92	118
+9015	PF09183	DUF1947		Domain of unknown function (DUF1947)	Sammut SJ	anon	pdb_1q7h	Domain	Members of this family are found in a set of hypothetical Archaeal proteins. Their exact function has not, as yet, been defined.	22.50	22.50	22.60	23.00	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.19	0.72	-4.21	7	27	2009-01-15 18:05:59	2006-08-17 16:16:08	5	2	27	1	13	24	4	64.70	45	42.26	CHANGED	pRHhlScK-tKhhhschcp.YGIDlou.tclEVuppK+phhYalssh.shFs-.pLIPTLhhlpphp	.QRHlhSpK-tKhhlsKlKp+Ys.IDlSs.s+lElGKEKKcs.aYYlsslL..u..F.Fs-...LIPTL.ChlhKhp...........	0	3	5	10
+9016	PF09184	PPP4R2		PPP4R2	Mistry J, Wood V	anon	manual	Family	PPP4R2 (protein phosphatase 4 core regulatory subunit R2) is the regulatory subunit of the histone H2A phosphatase complex.  It has been shown to confer resistance to the anticancer drug cisplatin in yeast [1], and may confer resistance in higher eukaryotes.	25.00	25.00	29.60	29.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.10	0.70	-4.86	15	305	2009-01-15 18:05:59	2006-08-17 16:18:36	6	3	245	0	201	303	0	204.50	22	50.95	CHANGED	shcpl.phhccFpchtpK.Elss.L-paLsclA+T.G-ThhsWsphKshhpaKlppVhcDFp....................tpsP..tchssssNV-shshE-MKcplLcllssFNu......hPFTIQRlCELLs-P..p+pY..sclDKFlRAlEKNlhVVSolpPssc+ssus......stsphsulh..................hststssahcc.t.............Vsssusscshs......csp..huss.ssNshssospscspphpp..-ccss.sussps-ss.s..sslt......sc+s-c--sppt-u-..........hEscphc.-c---Esc--p-pssss-	...............................................................................................................................t....................................................h..hh...h..h....ph..........................................................................p..........p................hpp.h...pphl.h.....p.h.l.s.sFss.......sPFTIQRLCELlhcP..p+p.Y.....sshsKal+AlEK...........slhVsS....s....h....t..........s......t...................................t........................................................................................................................................................................................................................................................................................s................................................................................................................................................................	0	64	106	162
+9017	PF09185	DUF1948		Domain of unknown function (DUF1948)	Sammut SJ	anon	pdb_1q8c	Domain	Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with one central alpha-helix surrounded by five others, in a NusB-like fold. Their function has not, as yet, been determined [1].	25.00	25.00	292.80	292.60	23.90	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.78	0.71	-4.52	2	4	2009-01-15 18:05:59	2006-08-17 16:25:49	5	1	4	1	2	4	16	140.00	87	88.33	CHANGED	LTRTQRRIAlVEFIFuhLFFLPKpA-.IQAsFL-YDs.ER.LN-WQK.IVKsFSEphhpF.chIEpQQ.+NQhElQoKYNKlSGKKlDLLTpAVlLCALSEQ+ApsTDKPLLISEALLIMDHYSQssEKKQTHALLDKLL	LTRTQRRIAIVEFIFATLFFLPKTADQIQAAFLDYDVPERPLNDWQKEIVKVFSERCVEFIELIENQQQRNQAEVQSKYNKVSGKKVDLLTKAVILCALSEQHAQATDKPLLISEALLIMDHYSQVPEKKQTHALLDKLL	0	1	1	1
+9018	PF09186	DUF1949		Domain of unknown function (DUF1949)	Sammut SJ	anon	pdb_1vi7	Domain	Members of this family pertain to a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement [1].	20.90	20.90	20.90	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.33	0.72	-4.36	181	2861	2012-10-02 20:07:24	2006-08-17 16:36:13	6	4	2841	2	493	1750	45	55.80	23	26.73	CHANGED	lphcYsphuplcphLp...p.ts.htlhcppYssp..Vplpltlstsphpshpptls-hosGp	......lphsYsphsplcthLt....p.ps.htlhssp.Yssp.....Vphpltl..s..tsc..h..pshpstLs-hopG...................	0	132	288	408
+9019	PF09187	DUF1950		Domain of unknown function(DUF1950)	Sammut SJ	anon	pdb_1vk5	Domain	Members of this family pertain to a set of functionally uncharacterised hypothetical eukaryotic proteins [1].	25.00	25.00	107.40	25.60	17.60	17.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.71	0.71	-3.96	3	18	2009-01-15 18:05:59	2006-08-17 16:49:10	5	2	10	3	11	22	0	110.80	59	64.70	CHANGED	LLR+.AEMYQ-YMKQlPIPo+R.GSlIPsTTWlGLGpSMKQLYGQPLHYLTNVLLQRWDQSRlGSDsEH+PLDSIIHPoKAEATIWlVEElHRLTTSoQHlAoLWtSDPMYHAFIDPIFPc	...llRR.AEMYQ-YMKpIPIPspR.GShIPFooWhGLu+SlKQLYsQPLHYLTNlLLKpWDQ.RlGS--Ep+sLDsIIHPsKAEATIWlhEElHRpToSphHlApLWtsDPMYa.uFlDsIFP......	0	1	7	9
+9020	PF09188	DUF1951		Domain of unknown function (DUF1951)	Sammut SJ	anon	pdb_1tm9	Domain	Members of this family of Mycoplasma hypothetical proteins adopt a helical structure, with a buried central helix. Their function has not, as yet, been determined.	24.40	24.40	26.40	30.50	23.70	24.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.92	0.71	-4.22	2	7	2009-01-15 18:05:59	2006-08-17 16:57:27	5	1	7	1	3	4	0	136.60	49	96.37	CHANGED	ME.NNlKEpLlShFppACSoHpERLDFICSsRESDTFSsVDVPLtPIKsIIEIsKsEppQhEIhKlAlpNIKTLSoVG.oGQYhASaFSTpsEsAIIFCl.YFLYHFsFL+DpNKKQllK+AaEslA-pIADYLNEN	..............EchlosFpphhopctp+hDFIpSVhEsDshuNh-hPht.lpplh-lhhNE.spp.hhphhIpshhTh.Tsh.php.lhShFppppplh.hFCl.YhLa+.sF.aD-sc+phlp+hhpslAcclh-hLs....	0	2	2	2
+9021	PF09189	DUF1952		Domain of unknown function (DUF1952)	Sammut SJ	anon	pdb_1v8c	Domain	Members of this family are found in various Thermus thermophilus proteins. Their exact function has not, as yet, been determined.	21.20	21.20	21.90	21.80	18.60	17.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.61	0.72	-4.28	2	11	2009-01-15 18:05:59	2006-08-17 17:05:56	5	2	11	4	4	11	0	77.60	56	49.80	CHANGED	GFERTFGAFPPWLLERYLEEWGGTREGEGVYRLPGAVVRFREVEPLKVGSLSIPQLhVEVEGEtuEtWFERIAhAASR	........htppFGAhPPWLLE+YLpEWGGp+-GEGsYRLPGAhVRFRElEPL+VGSLSIPQLcVEVEGEEA..EtWFERIAhAASR........	0	1	3	4
+9022	PF09190	DALR_2		DALR domain	Sammut SJ, Bateman A	anon	pdb	Domain	This DALR domain is found in cysteinyl-tRNA-synthetases [1].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.11	0.72	-3.72	124	4263	2012-10-02 19:03:26	2006-08-17 18:00:12	6	6	4170	6	980	3173	1201	63.60	30	13.64	CHANGED	cFtpAM-DDFNTspAlulLF-LA+clNp..........ttt.....shptt....pth..t......stLppL....uslLGl..lpp........ss..csal	..........pFhpAMsDDFNTspAluslF-hu+p.lNp...............pst.........sttst...........pth.....t......................stlc.ph...........sslLGl..ltpt..............................................................................	0	339	644	840
+9023	PF09191	CD4-extracel		CD4, extracellular	Sammut SJ	anon	pdb_1cid	Domain	Members of this family adopt an immunoglobulin-like beta-sandwich, with seven strands in 2 beta sheets, in a Greek key topology. They are predominantly found in the extracellular portion of CD4 proteins, where they enable interaction with major histocompatibility complex class II antigens [1].	25.00	25.00	25.40	49.20	21.40	24.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.46	0.72	-4.03	11	88	2009-01-15 18:05:59	2006-08-18 08:50:08	5	16	45	8	18	96	0	105.90	61	25.33	CHANGED	QKsSsTVYtKEGEQsEFSFPLsFp-ENL..pGELpW.QActASSsQSWITFoLcN+KVSVpKsppslKLQMpEsLPLpLTLPQsL.QYAGSGNLTLsLs..KGpLHQEVNLVV	....QKsSsTVYKKEGEQVEFSFPLsFptEpL.....oGELhW.Q.AEtASSupoWITFsLcN+cVSVpclppD.KLQMucpLPLpLTLPQALPQYAGSGNLTLsLs..pGK.LHQEVNLVV..................................	0	1	1	2
+9024	PF09192	Act-Frag_cataly		Actin-fragmin kinase, catalytic	Sammut SJ	anon	pdb_1cja	Domain	Members of this family assume a secondary structure consisting of eight beta strands and 11 alpha-helices, organised in two lobes. They are predominantly found in actin-fragmin kinase, where they act as a catalytic domain that mediates the phosphorylation of actin [1].	20.30	20.30	21.40	20.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.79	0.70	-5.42	7	59	2009-09-11 11:13:43	2006-08-18 09:14:55	5	5	31	2	47	61	0	252.30	26	38.15	CHANGED	sssuh..slsppthhhssIpsIsWssL.slchl-hu....................ssslhhlhThps.......t..p.....................................plllKuoso...Isp-sauSlLphlLtlPlPchRllc.ss.EappMopsLh.....tohpscpLhchIpoclpcsa.....hLIMEYhp.GpphscLspp......paFuspt.uc++hpQLGplluhDlhs......................................................NN.s+hP...ht.ssps.huNIlhh-pPp..GhhhsllsSslp...slssS.FshtY...................+pahsRl+.lLaolhQ...pPstEShQ...............lpphR-hl.pppshclsppSs...hplQp.....GIspGl	................................thttssh.......c.pshsWs...lpulcpocpu............................SuGVl..FhshFps...............t...........................................usVlKhu.so...hpuEhhuhcluchLG...lpsPpsRll.cpss........Eatphpcuhp.....huspp..s-p.ltchhp..pEl.hcuh.....lhlMpYlp.G.ps..Lh-.sps.............Fpsp....p.upcphpsLG+llhLDlll..........................pNpDRLP.t.LtWc..GNsuNlll.scc............h.tsh......t.....................................p.hh.pht....t....................................................................................................................................................	0	24	38	43
+9025	PF09193	CholecysA-Rec_N		Cholecystokinin A receptor, N-terminal	Sammut SJ	anon	pdb_1d6g	Domain	Members of this family are found in the extracellular region of the cholecystokinin A receptor, where they adopt a tertiary structure consisting of a few helical turns and a disulphide-crosslinked loop. They are required for interaction of the cholecystokinin A receptor with it's corresponding hormonal ligand [1].	20.30	20.30	20.70	24.70	20.10	17.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.33	0.72	-4.08	5	39	2009-01-15 18:05:59	2006-08-18 09:29:54	5	1	27	1	20	37	0	47.20	73	11.41	CHANGED	MDVVD.SLLsNGSNITP.PCELGLENETLFCLDQP+.PSKEWQPAVQILL	..MDVVD..SLLsNGSNITP.PCELGLENETLFCLDQPp.PSKEWQPAVQILL	1	1	1	3
+9026	PF09194	Endonuc-BsobI		Restriction endonuclease BsobI	Sammut SJ	anon	pdb_1dc1	Domain	Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence CYCGRG (where Y = T/C, and R = A/G) and cleave after C-1. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates [1].	25.00	25.00	53.90	53.90	21.60	17.50	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.92	0.70	-5.49	4	29	2012-10-11 20:44:45	2006-08-18 09:44:51	5	2	22	2	5	29	0	225.10	41	98.98	CHANGED	hPYp.HLpSsDDLhToYEthRAGFlALALEKN+RuTPaltcARALKltASpAcsPpDLLplcDIpsuLLsASGlSDKAtsaLp.pDKsEAIpsLIpNFLEPAGEpFVEELVaRFLLhRGDoLGGoMRNlGGsLAQpKhTRuIISsLslAsIuY+WLcSpsKp...Wh-ts-DDs-lElhlRGlSWp.pGcsRTlhYNlsVPlV.+pNlDlCLFsCcssplpsQ....pshpssshYIALGELKGGIDPAGADEHWKTApoALsRIRsAFs+tuhpPaTFFIGAAIE+pMAcEIWcQLpoGhLTNAANLTpssQluSlsRWhhpL	..........................spDLhTshpthhsGF...A.p+.t+usPalt.Achhp..hpp.hpp..pLhp..tlp.hllsAshhScKuhtaLp.p.p.chIptLI.sF.c.ssppalppL.h+aLLhpGDoLGG.MRNhsG..ApphhsphllstL...shs.ph....ppp................................................l.ppslDhhlhpht.tth........h....p.hlshGELKGGIDPAGADEHWKTApsALsRIhpAF.phthp.PhhhFlGuAIEhtMu.EIap.LppthLssAANl.p.pQlhpl.thhh...................	0	0	5	5
+9027	PF09195	Endonuc-BglII		Restriction endonuclease BglII	Sammut SJ	anon	pdb_1dfm	Domain	Members of this family are predominantly found in prokaryotic restriction endonuclease BglII, and adopt a structure consisting of an alpha/beta core containing a six-stranded beta-sheet surrounded by five alpha-helices, two of which are involved in homodimerisation of the endonuclease. They recognise the double-stranded DNA sequence AGATCT and cleave after A-1, resulting in specific double-stranded fragments with terminal 5'-phosphates [1].	21.60	21.60	22.40	22.00	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.89	0.71	-4.77	20	74	2012-10-11 20:44:45	2006-08-18 10:00:22	6	1	72	10	33	86	41	177.60	21	84.63	CHANGED	pApsllpp.phssthpEltpsLtshslphsclpsuutscptsp.hh.........cchltscGWtpch.............................................hh.......................sh-pps...........................pclDahK.........sslulElpauNhs.hh.pDLhp..aphhaspsh......IcVGllls.spshpc.................................................................chusussaaE+lhpcl.ptuc.ss.slPllllGls	............................................................................................................................................................................uttllt...thsp.hpEl.psltsh.php..h......tp.httss..tpptt..ht.hh...............ccthhtp.GW.pct.............................................ph..................................t..............................pplDahK.........sclulElpasshshhh.pDLhs....aph..h..a..p.tsh......IslGllIs...tspp.hpp............................................................phusussta-+hh.cl.ctup..ss.ssPllllGl...............................	0	12	27	31
+9028	PF09196	DUF1953		Domain of unknown function (DUF1953)	Sammut SJ	anon	pdb_1iv8	Domain	This domain is found in the Archaeal protein maltooligosyl trehalose synthase produced by Sulfolobus spp. Its function has not, as yet, been defined.	25.00	25.00	41.80	122.20	22.90	21.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.19	0.72	-4.27	2	2	2009-01-15 18:05:59	2006-08-18 10:11:54	5	1	2	2	1	3	0	64.50	49	9.06	CHANGED	EYKsLcLpcGLCGFhRhsKlLVIlKT...lNhchclE.su.YTDVlTsEpl+tcVplscLPhILV+	EYKsLcLpcGLCGFhRhsKlLVIlKT...lNhchclE.su.YTDVlTsEpl+tcVplscLPhILV+	0	0	0	1
+9029	PF09197	Rap1-DNA-bind		Rap1, DNA-binding	Sammut SJ	anon	pdb_1ign	Domain	Members of this family, which are predominantly found in the yeast protein rap1, assume a secondary structure consisting of a three-helix bundle and an N-terminal arm. They contain an Arg-Asp-Arg-Lys sequence that interacts with an ACACC region in the 3' region of the DNA-binding site [1].	22.40	22.40	22.80	22.40	22.30	20.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.56	0.72	-3.49	19	53	2012-10-04 14:01:12	2006-08-18 11:12:12	5	4	48	3	30	86	0	114.20	39	17.31	CHANGED	KFTA--DYpLshtlpc.hhpchhphsssputshhps.c...h.h.tph.h.........................tpFFcph.....................ucppP..sHTpsuWRDRaRKFlhsaG.lccYIcYYEppptsucpPcshKNhTs	.........................................................................................KFoA-EDYtLshslpcphhc-hhphDs-supshlpstct.shlscpphs.........................................sls+pFFcpa.....................uccas..sHTcsuWRDRFRKFlhsYG.lccYIpYYEspptpscpPEPM+NlT..........................	0	5	17	28
+9030	PF09198	T4-Gluco-transf		Bacteriophage T4 beta-glucosyltransferase	Sammut SJ	anon	pdb_1jix	Domain	Members of this family are DNA-modifying enzymes encoded by bacteriophage T4 that transfer glucose from uridine diphosphoglucose to 5-hydroxymethyl cytosine bases of phage T4 DNA [1].	25.00	25.00	56.40	55.20	17.90	14.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-7.91	0.72	-4.63	2	4	2009-01-15 18:05:59	2006-08-18 11:21:40	5	1	2	22	0	6	0	38.00	82	13.98	CHANGED	MKIAIINMGNNVINFKTVPSSETIYLFKVISEMGLNVD	MKIAIINMGNNVINFKTVPSSETIYLFKVISEMGLNVD	0	0	0	0
+9031	PF09199	DUF1954		Domain of unknown function (DUF1954)	Sammut SJ	anon	pdb_1m4v	Domain	Members of this family are found in various staphylococcal toxins, and adopt an OB fold, wherein the domain folds into a five-stranded beta-barrel. The exact manner in which they confer pathogenic properties to the protein has not, as yet, been determined [1].	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.82	0.72	-3.78	21	1637	2009-01-15 18:05:59	2006-08-18 11:49:10	5	2	161	29	14	384	0	83.10	38	33.87	CHANGED	pcL+pYYopsShEh+NloGht.pt...ps.phlphh.spphhplsLlGcDKcKa+c.ssc.pslDVFlVpEt.pchpuppYSlGGlTKoN	........cL+pYYopsShEhcNloGhh.p....tspphlphh.pp..phhpltLlGcDc.pKY+ctsp...slDVFhVpEt.pchpuphaSlGGlTKpN................	0	12	12	14
+9032	PF09200	Monellin		Monellin	Sammut SJ	anon	pdb_1mol	Domain	Monellin, a protein produced by the West African plant Dioscoreophyllum cumminsii, is approximately 70,000 times sweeter than sucrose on a molar basis. The protein adopts an alpha-beta structure, with a cystatin-like fold, where each helix packs against a coiled antiparallel beta-sheet [1].	23.60	23.60	23.60	87.80	21.90	23.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-7.73	0.72	-4.32	2	2	2009-01-15 18:05:59	2006-08-18 11:59:41	5	1	1	49	0	22	0	41.50	20	87.37	CHANGED	tEhchh-ht.a...oppLh+hslsE-.KhtththLpFNtsl.P	tEhchh-ht.a...oppLh+hslsE-.KhtththLpFNtsl.P	0	0	0	0
+9033	PF09201	SRX		SRX	Sammut SJ	anon	pdb_1nrj	Domain	Members of this family, which are predominantly found in eukaryotic signal recognition particle receptor alpha, consist of a central six-stranded anti-parallel beta-sheet sandwiched by helix alpha1 on one side and helices alpha2-alpha4 on the other. They interact with the small GTPase SR-beta, forming a complex that matches a class of small G protein-effector complexes, including Rap-Raf, Ras-PI3K(gamma), Ras-RalGDS, and Arl2-PDE(delta) [1].	25.00	25.00	26.20	141.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.91	0.71	-4.54	5	23	2009-01-15 18:05:59	2006-08-18 12:22:27	5	5	22	1	13	22	0	149.30	57	24.56	CHANGED	MFDQLAIFTPQGpVLYpYNsLsKKFSEsQlNuFIScLIopPVo+cc.......cshsSKLsoIs.o.pKsocSFoslFHloKQPELYFVlTYAE.pSLELNsEAEpVLsLuLpLWDSLsLN-uILcNhpG+ucKNcHNas-ILpulsE-IcKF-pYF	MFDQLAVFTPQGQVLYQYNCLGKKFSEhQINuFISpLITSPVT+KE.......cuh.casLLoIN.......S..p.....ccN........osSFsAhFalsKQPELYFVVTaAE.QTLELNQEspQTLsLsLKLWNSLcLsESIL+Nl.pGpsc.KNcHNYlDILpGl--DLcKF-QYF....	0	1	6	12
+9034	PF09202	Rio2_N		Rio2, N-terminal	Sammut SJ	anon	pdb_1tqi	Domain	Members of this family are found in Rio2, and are structurally homologous to the winged helix (wHTH) domain. They adopt a structure consisting of four alpha helices followed by two beta strands and a fifth alpha helix. The domain confers DNA binding properties to the protein, as per other winged helix domains [1].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.78	0.72	-3.91	29	449	2012-10-04 14:01:12	2006-08-18 13:09:27	6	7	407	5	321	479	8	80.70	43	19.50	CHANGED	h+aLop-DFRlLoAlEhGh+NHEhVPspLlsphupL+..tsusp+.tlpcLh+tcLls+...pstpY..-GY+LTYtGYDaLAL+sh.scR	..............hRaLsp-DFRV...LsAlEhG.h+NHEl..VPspLIsplusL+..puusp+.hlpcLsKhcLls+...cstpY................-..GY..RLTas...GYDaLAL+ohspR...................	0	105	187	266
+9035	PF09203	MspA		MspA	Sammut SJ	anon	pdb_1uun	Domain	MspA is a membrane porin produced by Mycobacteria, allowing hydrophilic nutrients to enter the bacterium. The protein forms a tightly interconnected octamer with eightfold rotation symmetry that resembles a goblet and contains a central channel. Each subunit fold contains a beta-sandwich of Ig-like topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel [1].	19.70	19.70	20.70	22.10	19.30	19.60	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.15	0.71	-4.83	19	280	2009-01-15 18:05:59	2006-08-18 13:29:33	6	2	59	10	90	299	3	172.20	25	80.36	CHANGED	PDGhp....lTVstpDEptsslPsLsss...hssRphhVuGshsus...........................lsGssst..ssGpLpsGY.lGCslslus.....hussuGhoPulsh..shss.s..s.uh.s.h...hsuuhsl....................sLtPGtlpsVslst.p-hcGsssa.................VthpshclplsGCsG.uhlRSYAslstpT-sssthlshYGtshsl	.......................................sGhp....lslp..ttsphhsslssL.sss....hoREhal..S.....Gpsssp.........................lsG..sust.....hsupLpsGY...plGCthslus................hss.ss.G.ss.suls.h...........shs.s......s..............................ss..s..l..ssulsl...................................................sltPGtltsls.l.p....hshpsssst........................lslssh+lplsGCuG.stlRuaApl...........pssTssspt.lshYGpPhsh...................................	0	10	60	76
+9036	PF09204	Colicin_immun	ColicinD;	Bacterial self-protective colicin-like immunity	Sammut SJ	anon	pdb_1v74	Domain	Colicin D, which is synthesised by various prokaryotes, adopts an antiparallel four helical bundle fold: the helices are tightly packed, forming a compact cylindrical molecule. The protein specifically cleaves the anticodon loop of all four tRNA-Arg isoacceptors, thereby inactivating prokaryotic protein synthesis and leading to cell death [1]. This family also contains immunity proteins to klebicins and microcins. Many bacteria produce proteins that destroy their competitors. Colicin D is one such. The immunity proteins are expressed on the same operon as their cognate bacteriocins and protect the expressing bacterium from the effects of its own bacteriocin [2].	21.60	21.60	23.60	23.20	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.88	0.72	-3.90	10	59	2009-11-02 17:58:57	2006-08-18 13:44:51	5	1	47	3	11	46	0	78.90	43	88.30	CHANGED	MS.hsll-LA+sFlpp+lSAppFoEsahphW+lERcsthhl+D.spslscCLuplFshADhYsPDs-.R--..YElD--pLRcEV+plLcKap	...................Ms.hhllchA+pFlstcloAp.Fuptahtha+hEpcpt.hhpD..spplspsLsslFshADhYsPDsD...RE-...YElDDcpLhcpVhpllsKhp.....	0	2	6	9
+9037	PF09205	DUF1955		Domain of unknown function (DUF1955)	Sammut SJ	anon	pdb_1vdu	Domain	Members of this family are found in hypothetical proteins synthesised by the Archaeal organism Sulfolobus. Their exact function has not, as yet, been determined.	23.70	23.70	23.70	188.30	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.00	0.71	-4.71	4	17	2009-01-15 18:05:59	2006-08-18 13:52:30	5	1	17	1	6	12	0	159.40	67	94.03	CHANGED	Ell+KLM-AK+hllDGhl-cGlcIlpchspSSshcEhNWhICNllDohsCchlhpsL-sIGphFDlotCtNLKpVlpChhhhNp.SEaVDhALDhLVtpsK+DpL-cIhp-lh..NpclssplLlKIAsAh+KlGspR-us-LLpcACc+GlKEACpslspl	.ELRRKLIEAKKLILDGFVEQGIELLSKTIoSENIKESNWIICNVIDTADCDAVVKTLDSIGKIFDhSPCANIKRlVYCYALlNKsSEYVDLALDlIVKuNKKDuLDKLYNDLK..NEKINPEFLLKIGhAYKKLGAV+ESNEVLRKACENGLKEACENIKEI..	0	1	1	5
+9038	PF09206	ArabFuran-catal		Alpha-L-arabinofuranosidase B, catalytic	Sammut SJ	anon	pdb_1wd3	Domain	Members of this family, which are present in fungal alpha-L-arabinofuranosidase B, adopt a beta-sandwich fold similar to that of Concanavalin A-like lectins/glucanase. The beta-sandwich fold consists of two anti-parallel beta-sheets with seven and and six strands, respectively. In addition, there are four helices outside of the beta-strands. The beta-sandwich strands are closely packed and curved with a jelly roll topology, creating a small catalytic pocket. The domain catalyses the hydrolysis of alpha-1,2-, alpha-1,3- and alpha-1,5-L-arabinofuranosidic bonds in L-arabinose-containing hemicelluloses such as arabinoxylan and L-arabinan [1].	25.00	25.00	26.10	25.70	24.50	23.20	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.19	0.70	-5.48	7	132	2009-01-15 18:05:59	2006-08-18 14:15:12	6	11	81	4	81	133	29	312.70	58	63.03	CHANGED	PCDlYuuusTPClAAHSTTRALYuuYoGPLYQVpRuSDGsTsDI.......uPLo.AG....GVANAuuQDsFCANTTClIoIIYDQ..................................Su+GNHLTpAPsG.uFsG...PsssGa........................DNLAsA.GAP.....VoLsGpKAYGVFloPGTGYRNN.sspGoAsGDpsEGhYAVLDGTHY..NuuCCFDYGNAETsStDTGs.......GHMEAIYF..GssTlWGp..GsGsGP..............WlMsDhENGLFSGsss...c.NuusPuIs.RFlTAllKGps....shWAIRGGsAuoGuLSTaYsGsRPssoGYsPMuK.......EGAIILGIGGDNS.GAQGTFYEGsMToG..aPSDATENtVQANlVAAtYusss	.........PCDIYuuGGTPCVAAHSTTRALYuuYsGsLYQV+RuSDuuTpsI..............usLo.A.G....GlAsAA.....AQDoFC..Au.TTClITlIYDQ..................................SG+GN+LTpAPsG..uh.pG.......Ps.s.sGh.......................................DsL.As....A.huAP.......VTl.sG.pKAYG.Val.uP..GsGY.RNN.ss.sGs..ATGDpsEGhYAV..hDG....THY....NuuCCFDYGNAETs....spDsGN.............................GpME.AIYF..Gsss..h.aGs.....GuGsGP..............WlMADLENGLF..S.G.sss......t.NsssP...olstR.FVTAhlKGps....spWAlRGGNApSGuLoTaYsGs.RP.t.........s...............GYsPMpK.......EGAIILGlGGD......NS.....suupGTFYEGVMToG..YPSDATENuVQANIVAAtYus.u...................................................................................	0	32	52	74
+9039	PF09207	Yeast-kill-tox		Yeast killer toxin	Sammut SJ	anon	pdb_1wkt	Domain	Members of this family, which are produced by Williopsis fungi, adopt a secondary structure consisting of eight strands in two beta sheets, in a Greek-key topology [1].	21.50	21.50	22.00	196.20	21.10	20.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.28	0.72	-3.55	2	2	2009-01-15 18:05:59	2006-08-18 14:27:41	6	1	2	1	0	4	0	86.50	88	69.48	CHANGED	DGYLlMCKNCDPNoGSCDWKQNWNTCVGIGuNVHWMVTGtS.sGpQGCAhIWEGSGCsGRSTTMCCPusTCCNINTGFYIRSYRRVE	DGYLlMCKNCDPNoGSCDWKQNWNTCVGIGuNVHWMVTGtS.sGpQGCAhIWEGSGCsGRSTTMCCPusTCCNINTGFYIRSYRRVE	0	0	0	0
+9040	PF09208	Endonuc-MspI		Restriction endonuclease MspI 	Sammut SJ	anon	pdb_1sa3	Domain	Members of this family of prokaryotic restriction endonucleases recognise the palindromic tetranucleotide sequence 5'-CCGG and cleave between the first and second nucleotides, leaving 2 base 5' overhangs. They fold into an alpha/beta architecture, with a five-stranded mixed beta-sheet sandwiched on both sides by alpha-helices [1].	25.60	25.60	26.00	82.40	25.00	25.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.58	0.70	-5.32	3	10	2012-10-11 20:44:45	2006-08-18 14:41:34	5	1	10	4	4	9	1	265.90	35	70.46	CHANGED	YTchLSDlLs......clsEKs..phtpGlpus+LGNcaE+aIV-lLNDlcNLutYNsNppAQpchc....cIhcclLccLsL-ctaDpILEVTuTs.DIs+LpNGGSPKTDlolRlphssKEh+IsNISIKNTpcK+VSIHEYsVcDlloslulSDoD.L+pLlc+FQcsGStKcFsulpsp+splL-ps..LcPYpE+lIcWsVT..up+stssLLc-KIQlsshIIsRNtsuVssK..DDYlKcYIEEhStAhGKG.FGTPFsWTYPSK+RGQKIQlKG	............hpp.Lo-lhs......pI.EKAspNlupGlRuslLGNshEppIVNlLNDlcNlshWNs.pssppshc...YcIaKcIlccl..slc.cth..-pIl-loAT...s.-IPhLp....NtGKPKTDVpVTIpsss..Kch.IhsISlKp..TpcppVoIHEhoVccllosLclS...-S.....D....LppALc+FQcVGStKKlhsppssptclL-cp..LcsYN+cLIcahls..u.hu.sslls-KIQhsshIIspsphsVhs+.....D-Yl+cYIpEhstt.uKGtFGTPFpWTYPSKKRGpKIQlKG.	0	1	4	4
+9041	PF09209	DUF1956		Domain of unknown function (DUF1956)	Sammut SJ	anon	pdb_1t33	Domain	Members of this family are found in various prokaryotic transcriptional regulator proteins. Their exact function has not, as yet, been identified.	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.24	0.71	-4.19	57	836	2012-10-03 00:15:22	2006-08-18 14:51:42	6	2	775	2	151	427	30	123.30	42	54.72	CHANGED	scppLpshlcshlth..lhsp....psthhs+hhhRE...hpP.osAhc..plhpphhtPhpphlsplluplhGts......ssstphthpshollGpslhatlu+pshhthhs...shsst.htplpslhpch..hphhLsul	..........................................h.R-hlltAh+sMlph...Lsp-....-T.lsl.....SK.FluREQ....L..SP..TuA.Yc..LlH-Q...VIsPLH...s+LsRLlAAaTGsD......A.sDo.ch.lLH.THALlGplLAFRLu..+ETILhRsGWs..saDc-cs-hIsp.sVssHl-llLpGL................................	0	40	90	121
+9042	PF09210	DUF1957		Domain of unknown function (DUF1957)	Sammut SJ	anon	pdb_1ufa	Domain	This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been defined.	25.00	25.00	28.40	27.10	22.80	19.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.27	0.72	-3.96	57	366	2009-09-10 21:40:42	2006-08-18 15:02:37	6	6	355	5	163	338	133	102.80	33	18.87	CHANGED	.clccAscpMlclssphs...t.sstlpp..RsLsQAARELLLAQSSDWuFIhpssTss-YAtcRhccHlpRFhcLhptlp....pspl........s....pphLpplEttDslFPpIsa+..ha	...........................h.pstpphhchspt...........ssthcc...RsLsQhsRElLLspSSDWsFllsssoss.......-YAppRs+pHhppFpclhpslt....suc.h........-.......pchL.p.t.hcp.tDslFs.slDhRha......................	0	67	120	148
+9043	PF09211	DUF1958		Domain of unknown function (DUF1958)	Sammut SJ	anon	pdb_1tvf	Domain	Members of this functionally uncharacterised family are found in prokaryotic penicillin-binding protein 4.	23.40	23.40	23.70	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.14	0.72	-3.90	9	328	2009-01-15 18:05:59	2006-08-18 15:22:48	5	2	303	6	15	172	0	65.70	53	15.00	CHANGED	YKKlLSKGppcIDGKKYplccDLYDVVPKspst...+lhlc-.GplplDhsRpalssphtss.pVpspc	....YhKlLSKGEQcIsGKKYhVcNDLYDVlPpchsp...aKlsVED.G+.V+sDYPRcFlNpchuPP.oVEspp.......	0	2	3	13
+9044	PF09212	CBM27		Carbohydrate binding module 27	Sammut SJ	anon	pdb_1oh4	Domain	Members of this family are carbohydrate binding modules that bind to beta-1, 4-mannooligosaccharides, carob galactomannan, and konjac glucomannan, but not to cellulose (insoluble and soluble) or soluble birchwood xylan. They adopt a beta sandwich structure comprising 13 beta strands with a single, small alpha-helix and a single metal atom [1].	19.50	19.50	21.70	20.10	19.20	17.00	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.07	0.71	-4.24	2	51	2009-01-15 18:05:59	2006-08-18 15:57:36	5	14	33	6	9	53	0	171.90	24	23.72	CHANGED	hQ.s.A.El..pFShsp-hpNhassGTWQApFthPsIp...pststsLphNVsLPGpuDWEEV+V.lp.hspLs.sphlpaDlhlPcV-.lsGtLRPYhsLNPGWlKIGlD..psslsshphVohcsppY+hhHVplEFsthPsVNELalslVGs+LtYcGPIaIDNVpLaKK	...............................................t..........................................ht..t....t......sssuLclsls.hsss..s..s.W-Ehc.......l....h......p......th.....t.......c...l..sshptlca-.lalP..ps..p..t...h...s.Gslps.........h.us..l...s..s.GW.s.c....l....shsh.p.ph.s..lpshcp.l....pl..s.GppYtp..hpssh....p....h...s...p...s...t...p.hs...pL...hlplsGsphsY.sG..sIYlDNlcL...t...	2	5	7	9
+9045	PF09213	M3		M3	Sammut SJ	anon	pdb_1mkf	Domain	Members of this family of viral chemokine binding proteins adopt a structure consisting of two different beta-sandwich domains of partial topological similarity to immunoglobulin-like folds. They bind with the CC-chemokine MCP-1, acting as cytokine decoy receptors [1].	25.00	25.00	104.10	104.00	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.24	0.70	-5.99	2	8	2009-01-15 18:05:59	2006-08-21 09:23:23	5	1	3	8	0	9	0	332.90	57	90.18	CHANGED	SsVshpohshsp.cpt--hpsa......CLh.sphpsT.Cus.hccl.p+shapL.shCNVKsphhVsa.shcchG..hhpuRLPhPohuusssscll+VLVlAEus....pP.ccaaA.lth.T...shtLoD.NshFpoca.plW.lsls+p.VDlshhhtuhhhtt..usplTlhhsYssTFTWCGpl.uls-.shP.PShpAhpsl...Chs.hRY.sup.Fpc.DGCptEoth.p.ohlhPh...Gs.spphphNTCsCahKYs.lp.Lsshc+lhlhslush.uhhpPlYVhssYFsSoc.Ns.t.us.L.aCsl.hppts.Ghapo..pus.pCPh+hs.Gpsp.VL.s+hs..sh.plVGlolhh-GQpaRlpYhG	SsVshpohshsp.cpt--hpsa......CLh.sphpsT.Cus.hccl.p+shapL.shCNVKsphhVsa.shcchG..hhpuRLPhPohuusssscll+VLVlAEus....pP.ccaaA.lth.T...shtLoDhNshFpoca.pIW.lsls+p.VDlshhhtuhhhtt..usplTlhhsYssTFTWCGpI.uls-.shP.PShpAhpsl...Chs.hRY.sup.Fpc.DGCptEosh.p.ohlhPh...Gs.spphphNTCsCahKYs.lp.LsAhc+lhlhslush.uhhpPlYVhssYFsSoc.Ns.tPusKLYHCALQMTSHD.GVWTS..TSSEQCPIRLVEGQScNVLQV+VAPTSMP+LVGVSLMLEGQQYRLEYFG	0	0	0	0
+9046	PF09214	Prd1-P2		Bacteriophage Prd1, adsorption protein P2	Sammut SJ	anon	pdb_1n7v	Domain	Members of this family form a set of bacteriophage adsorption proteins, composed mainly of beta-strands whose complicated topology forms an elongated seahorse-shaped molecule with a distinct head, containing a pseudo-beta propeller structure with approximate 6-fold symmetry, and tail. They are required for the attachment of the phage to the host conjugative DNA transfer complex. This is a poorly understood large transmembrane complex of unknown architecture, with at least 11 different proteins [1].	25.00	25.00	1204.10	1203.90	17.00	16.70	hmmbuild  -o /dev/null HMM SEED	560	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-13.00	0.70	-5.95	2	7	2009-01-15 18:05:59	2006-08-21 09:39:33	6	1	6	2	0	8	0	555.70	90	93.92	CHANGED	AshsVPKLG.FPshAVhDIDNVP.DSSsTGSRWLPSlYpGuNYauGGPQtLpAphusFDSssRLPYNPRT-sNPAGNCAFuFNPFGQYISNISSAQSVHcRIYGID.NsEPLFoPNAASITNGGNPTMSQDhsYHNIGPINoAYKAEIFRPVNPLPMSDTsPDPETLEPGQs.PlIKoDGlYosSGIAuFIFD+PVTEPNPNWPPLPPP.IPIIYPhPALGIGAAAAYGFGYQVThYhWEplPVEFIADPtTCPApPTTDKVIIRTTsLNPEGoPCAY-suIhLVRQsuNPMNAVAGRLVP.V.DIsVDIFLTGKFFsLsPPhRlTNNYFAD-pVpE.TVThGNapsshuusYatVYpTDGhGhApsFIu.GGuGlSALlpLQDsoVlD.LaYSlPLSlGGStushcEWlANNsGhaPhShGhsKosLlEIPRRpLEAIpPQssPG..DlFhLD-SuuYASFSSFIGYspuAYYVAGAuTFMDVENPDpIIFlLRsGtGWYuC-IuDALhI.....uDsEaDSVDYFAapGGVMFIGSARYTEGGDPLPIKYRAlIPuLP	ANFNVPKLGVFPVAAVFDIDNVPEDSSATGSRWLPSIYQGGNYWGGGPQALRApVSNFDSsNRLPYNPRT-sNPAGNCAFAFNPFGQYISNISSAQSVHRRIYGIDPNDEPLFTPNAASITNGGNPTMSQDTGYHNIGPINTAYKAEIFRPVNPLPMSDTAPDPETLEPGQs.PLIKSDGIYSsSGIAuFIFD+PVTEPNPNWPPLPPP.IPIIYPTPALGIGAAAAYGFGYQVTVY+WEEIPVEFIADP-TCPAQPTTDKVIIRTTDLNPEGSPCAYEAGIILVRQTSNPMNAVAGRLVPYV.DIAVDIFLTGKFFTLNPPLRITNNYFADDEVKENTVTIGNYTTTLSSAYYAVaKTDGYGGATCFIASGGAGISALVQLQDNSVLDVLYYSLPLSLGGSKAAIDEWVANNCGLFPMSGGLDKTTLLEIPRRQLEAIsPQDGPGQDDLFILDDSGAYASFSSFIGaPESAYYVAGAATFMDVENPDEIIFILRNGAGWYACEIGDALKI.....ADDEFDSVDYFAYRGGVMFIGSARYTEGGDPLPIKYRAIIPALP	0	0	0	0
+9047	PF09215	Phage-Gp8		Bacteriophage T4, Gp8	Sammut SJ	anon	pdb_1n7z	Domain	Members of this family of viral baseplate structural proteins adopt a structure consisting of a three-layer beta-sandwich with two finger-like loops containing an alpha-helix at the opposite sides of the sandwich. The two peripheral, five-stranded, antiparallel beta-sheets are stacked against the middle, four-stranded, antiparallel beta-sheet. Attachment of this family of proteins to the baseplate during assembly creates a binding site for subsequent attachment of Gp6 [1].	25.00	25.00	86.40	25.90	19.70	24.30	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.86	0.70	-5.28	10	76	2009-01-15 18:05:59	2006-08-21 09:49:36	5	2	62	12	0	68	1391	281.80	34	83.52	CHANGED	uIVT...sKFRTcshhNFYcolG...............Dsss+sTIYhoFGRscsWucNEs-stFAPPYPsDShcGlsDsWocMlGslKIspShLcsVVPR+DW...............................GDoshssPppFaluDIVVVNStPhNpT-.u.uGWMVYRClDlP-s........GtCSIsolssKsEClplGGcWTss.....tcSltsPpGpusu...I-sG.DGYlWEYLYTIPPDssINcCTNEaIVVPaP-ELhtDPsRWGY-ssls...........W.ssch-llYRhKssTlRF+AahDSlhFspsuhsGNpGFRQlSlIlNPL.hKucPsss-VKAsts.tYsspplphcSGpMI.........YMENRpPIh+ohDQTEElsIlFsF	.....................................ullT...spFRh.phhpFhps.lt...............ss.spsplYhhhGRspsWsspp...........uPP...PsDshpthtshaspMhuhh+l.tS.httVl.RhDW.........................ucsthss...shphh.s-hhVsN...........usa.VY+Cl.ssss........s............s...Gt..Tsp.....hpS...sth.........lss...G.DGYhWcYlYpIPsssslphhoN-ahsV..........sphuhcssls...........a.pschchlah.p..ssoh.p......puhhDul...hspsuhsGstG..plSllssP..tpupsssssVcus...ts...sYshsclphcSGphl.........Yh-NRpsIhpuhDQsE-lpIlhpF....................................	0	0	0	0
+9048	PF09216	Pfg27		Pfg27	Sammut SJ	anon	pdb_1n81	Domain	Members of this family are essential for gametocytogenesis in Plasmodium falciparum. They contain a fold composed of two pseudo dyad-related repeats of the helix-turn-helix motif, serving as a platform for RNA and Src homology-3 (SH3) binding [1].	25.00	25.00	119.70	118.90	22.30	19.90	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.29	0.71	-4.69	2	7	2009-01-15 18:05:59	2006-08-21 10:00:20	5	1	5	1	4	8	0	176.60	49	44.52	CHANGED	Y+YEc..cpctsL.shIppls-lEFpusss..YLhhhlspD..KaN.uLpDp.uIh+.lpKsQNch..hhl..clpsshs.RIS-RLhsashDK-lTt.YlKKlcDhhhlEpcshcph.h.Vcpt+php-KKRlhNshc.I+hha-o...hp.lphscDph.sAhhRlSphlsDl........I.hLP	.............................hI.plhplEFcssps..YLhhhls..pD.EKaN.uLcD+luIh+.lpKNQN+as.Fhl..clpDshs.RISDRLhsYChDK-lTEsYlKKlcDhhhlEpcVhEpl.h.V-Ht+ph+EKKRlhNDhcLI+hha-oh.hspslphTDDQacsAAhRlSpFl.Dl........I..........	0	2	2	3
+9049	PF09217	EcoRII-N		Restriction endonuclease EcoRII, N-terminal	Sammut SJ	anon	pdb_1na6	Domain	The N-terminal effector-binding domain of the Restriction Endonuclease EcoRII has a DNA recognition fold, allowing for binding to 5'-CCWGG sequences. It assumes a structure composed of an eight-stranded beta-sheet with the strands in the order of b2, b5, b4, b3, b7, b6, b1 and b8. They are mostly antiparallel to each other except that b3 is parallel to b7. Alternatively, it may also be viewed as consisting of two mini beta-sheets of four antiparallel beta-strands, sheet I from beta-strands b2, b5, b4, b3 and sheet II from strands b7, b6, b1, b8, folded into an open mixed beta-barrel with a novel topology. Sheet I has a simple Greek key motif while sheet II does not [1].	25.00	25.00	34.10	33.60	24.40	23.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.92	0.71	-4.65	6	84	2012-10-02 12:51:43	2006-08-21 10:21:06	5	3	73	3	10	59	2	147.10	46	39.22	CHANGED	chuscsahhahKRLoANDTGATGuHQuGhYIPpshsppLFPslN+s+-pNPolhlss+hpSHpssDSphRAIYYNs+hhs...tTRNEtRITpaGtuts.hhs.csTGALsllAF...ctstcsthscsWVCsos-EtDllEutlGpllPGu....lhss.uupI	..........sspshhlYlKRLSANDTGATGGHQsGlYIPpsh.s-c..LFPslsc..s+phN..Polhlps+hsoc.sss-.SphRhlYYNs+has...tTRNEtRITRaG+s.s.l.ss-NTGuLhlLA.....cts.....tcsp.hphaVhsos-E.Dlh.sthGpllPGs....Lh.s.ttpl..................................	0	4	6	8
+9050	PF09218	DUF1959		Domain of unknown function (DUF1959)	Sammut SJ	anon	pdb_1nxh	Domain	This domain is found in a set of uncharacterised Archaeal hypothetical proteins. Its function has not, as yet, been described.	21.10	21.10	21.70	21.40	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.54	0.71	-4.31	5	29	2009-09-10 17:31:46	2006-08-21 10:27:44	5	1	29	2	19	28	0	115.10	42	84.75	CHANGED	KhNlIKuNRalMEDVIlPISKALKlslEEVIDIFscKLDhuSLYELHAYsEQA+MGCLGRKVDIDLGLCWlsDFFGLISK-DADLIRKKVVE-hIlcKKPYKEALEEGR+hllcLLK	............KhplIcs.Ra.hE-lllPlSKtLplsh-Elh-lFhcphDhuoL.plHAhhEpA+hsCLsc+lDhD.LuLCWlsDahsLIS+c-ADhIRcKVscphllpp+sYc-AL-EGRphllclLK.....................	0	4	9	15
+9052	PF09220	LA-virus_coat		L-A virus, major coat protein	Sammut SJ	anon	pdb_1m1c	Domain	Members of this family form the major coat protein of the Saccharomyces cerevisiae L-A virus [1].	25.00	25.00	27.00	25.30	23.30	21.20	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.35	0.70	-6.03	2	18	2009-12-01 14:28:50	2006-08-21 10:41:59	5	2	13	2	5	23	0	311.60	31	49.63	CHANGED	ML+FVsp.spctpssLap.ppscGThsshsRlRsDFKaDsLsFsRshssSQcaThVGpshsshsEspS.L-GlsKKYLTLDGuluhDNVhpEL+sosGh.uNhlAuHAYNlsuWRWYDNHVALLhNhLRhYhLpsLsEpuphSsGchPhYcDGHVhIcLssTl..pstsspasWPucRus-SYP.Ws.hoE.hPshDsPalDlRPLT.pEsphVLMMhucW+.pTNhtlDa.sPpLA-KhhYRat.slpshsEWl-u-tTsspah.PpS+VhhSALRKYVsHNpLYNQFYTAspllAQlMhpshPssAEGhsWLhHss.VplPKFGSlRGRYPFL.SG-AAhIQApALEDWuAlhAKPELlFTYuM.lussLNhGLhlRcsKtohhhsp.csSa-DshFLpPETFhtuAluhsTG.DAPLNGMuDVYVhYP-Llph	.................................................php..hps...p+.h........p.hs.lG...s.hsps.s.L-Gltt.hhs.cGslshs.l..tLpp.shh.ts..s.p.ht.tth.ahcNhsuLLhNhLRhYhlt.ltp.tth.pssph.hYcsGHspl..s.tl...sts.pht...WP.....spt.ptths.hs.h....P...ssshl.hpshs.pcsthlL..hhupat..sshtlsa..PpLspphhhph...ht..s...........h..h..psthhhsAl+cYVstNplYspF.sAhtlluQlhhoshPssAEuhsWLhp.s.VslPpFuSlRGhYPhL.pG-uhhhptpAl--WsthhspP.phlFohu..Mhhuss...lphGLhhRpsphp.hhst...th-p.hhlpscohhtuhhuhsoG.phs..t.tshhh.........................	0	0	1	5
+9053	PF09221	Bacteriocin_IId	Bacterioc_AS-48;	Bacteriocin class IId cyclical uberolysin-like	Sammut SJ, Coggill P, Eberhardt R	anon	pdb_1o82	Domain	Members of this family are membrane-interacting peptides, produced by Firmicutes that display a broad anti-microbial spectrum against Gram-positive and Gram-negative bacteria. They adopt a helical structure, with four or five alpha helices forming a Saposin-like fold [2,5].  The structure has been found to be cyclical [1, 3, 5]. It should be pointed out that one reference [4] implies that both circularin A and gassericin A are class V or IIc-type bacteriocins; however we find that these two proteins fall into different Pfam families families, this one and BacteriocIIc_cy, Pfam:PF12173.	23.00	23.00	23.30	23.00	22.00	21.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.14	0.72	-4.06	17	111	2009-09-11 17:00:14	2006-08-21 10:51:36	5	1	108	12	12	62	0	63.50	51	69.18	CHANGED	AutlGIususAtplVsllssuuolsolIulluulsuuGshu.......sulhAslKphlp+pGpttAssW	.......AGTLGISTtAAsTVVNlIsAhSTVsulISIV.GAlTGsGuIu.......uGIsATVhhllKKpGtAtAAhW.......	0	5	8	9
+9054	PF09222	Fim-adh_lectin		Fimbrial adhesin F17-AG, lectin domain	Sammut SJ	anon	pdb_1o9w	Domain	Members of this family are carbohydrate-specific lectin domains found in bacterial fimbrial adhesins. They adopt a compact, elongated structure consisting of a beta-sandwich with two major sheets: one consisting of five long strands in mixed orientations, and a front sheet with four antiparallel strands, forming an immunoglobin-like fold [1].	25.00	25.00	25.40	25.10	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.22	0.71	-4.97	2	22	2009-01-15 18:05:59	2006-08-21 11:05:39	5	1	9	15	0	29	0	167.20	50	47.14	CHANGED	VSFIGSTENDVGPS.GSYSpTHAMDNLPFVYNTG.NIGYQNANVWRIStGFCVGLDGKVDLPVVGSLDGQSIYGLTEEVGLLIWMGDTNYSRGTAMSGNSWENVFSGWCVG.NhsSTQGLSV+VpPVILKRNSSApYSVQKTSIGSIRMRPYNGSSAGSVQTTVNFSLNPF	................................................................PS..uYSpsauhDNLPFha.N.sGhsI.......tYQsuNs.....a+h.....osG......FCssL-uKsDLPVlGoLDGQSIYsLT-E..lGlLIahGDTNYSRsoAhsGNSWpsVFSG.WCsu...hSoQGhSV+VhPVlLKps.uu.upYoV.+TpIGSIRhR.hssSphGph................................	0	0	0	0
+9055	PF09223	YodA		YodA lipocalin-like domain	Sammut SJ, Bateman A	anon	pdb_1oej	Domain	Members of this family of prokaryotic domains have been identified as part of the response of bacteria to a challenge with the toxic heavy metal cadmium. They are able to bind to cadmium, and ensure its subsequent elimination [1].	20.50	20.50	20.60	20.90	19.80	19.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.17	0.71	-4.63	33	1239	2012-10-03 08:47:39	2006-08-21 11:21:21	6	5	1174	5	75	565	3	177.80	56	49.23	CHANGED	-pccplhpGYF-DspVKDRsLSDWpGcWQSVYPYLpcGTLDtVhsaKAccsc.chTApEYKsYYcpGYpTDV-pIsI..cssslTFhp.sspspospYpYsGacILTYcpGNRGVRalFcts-usu.st..P+YlQFSDHsIuPpKusHaHlYaGs-ppt.LLcEl-NWPTYYPupLouc-IscEMlAH	...................................-.s-ppstsGhF-DssVcD..RsLSDasGsWQSVYPaLpsGpLD.....VFchKAct.s.t..chThtEhKsYYcK.GYpT.DlppIsI..c.c.s..p.lEFhp.....s......s....p.....s....p..o.s.p.Y.cY.sG....hK.IL...TYppGp+.GV....R....a....L....FEs...p.Ds..s.u..tt..KY.lQF......SD.H.IA.P.p.K.u.pHFHIFhGs-SQpuLL...p.EM-N...W.PTYY.P.pLoupElspEMluH............................	1	20	36	56
+9056	PF09224	DUF1961		Domain of unknown function (DUF1961)	Sammut SJ	anon	pdb_1oq1	Domain	Members of this family are found in a set of hypothetical bacterial proteins. Their exact function has not, as yet, been determined.	25.00	25.00	28.80	25.80	19.50	16.40	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.61	0.70	-5.25	3	41	2009-01-15 18:05:59	2006-08-21 11:26:34	6	1	38	4	21	39	9	214.70	46	84.29	CHANGED	REG.uLLYpNPLuSPcDV+GWVMEGsGpluFcDGuLHLSs.hDsEclGD-AHFVFWCPETFPDGIlVoWDFhPlcEPGLCMlFFAAAGhsGEDLFDucLAcRTGpYPQYHSGDINALHLSYFRHKHA-ERAFRTCNLRKSRGFHLVApGADPLPPs-DAcsPYRMKLIKDGuYV+FSINGLPILEWTDDGcRaGPVLGuGKIGFRQMAPL+AAYRNFsV	......................................................thlYpNsLpSspDVtsWhhEG.su.ploh...sssthcLp..h...phsppu+FVaWCPEsFPDsI..hloW-FpPlc-..PGLsMLFFuA.AGhs..Gc.DlF.DsuLt.....RTGpYPpY..HSGDINsLHlSYFRR+as-ER.AF+TCNLRKStGF.HLVApGADPl.PsssD........Ap.u......sYRh.cllKDtstV+FuI.N......sLPlhpWpDDG.ss.hGPVLspG+IGFRQMAPhtAsY+sLpV....	0	9	15	20
+9057	PF09225	Endonuc-PvuII		Restriction endonuclease PvuII	Sammut SJ	anon	pdb_3pvi	Domain	Members of this family are predominantly found in prokaryotic restriction endonuclease PvuII. They recognise the double-stranded DNA sequence 5'-CAGCTG-3' and cleave after G-3, resulting in specific double-stranded fragments with terminal 5'-phosphates [1].	25.00	25.00	118.70	118.40	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.89	0.71	-4.53	3	14	2012-10-11 20:44:45	2006-08-21 11:42:23	5	2	14	21	3	19	2	144.30	63	82.21	CHANGED	HsDhsKLlcLWPpIcEYQcLAsKHGINDIFQDNGGKLLQVLLILGLTVLPGREGNDAVDssGsEYELKSVNlELTKuFSTHHHMNPsIIAKYRQVPWlFAIY+NIsIcuIYRLcPDDLEsFYDKWERKWY-DGGKDINNPKIPVKYVMEYGclIW	.......DhttL.tLaPplpcaQtLAp+aGINDIFQDNGGKLLQVLLlhuLp.llPGREGNDAVDssGsEaELKSVNl-LT.KSFSTHHHMNPsIIuKYRQVsWlFAlYpsIslpplYhLpPc-LEsFYsKWEcpWapcsGKDINNPKIPlKYVhEaGplla...	0	0	2	2
+9058	PF09226	Endonuc-HincII		Restriction endonuclease HincII	Sammut SJ	anon	pdb_1xhv	Domain	Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence 5'-GTYRAC-3' and cleave after Y-3. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates [1].	19.30	19.30	20.10	312.90	18.70	19.20	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.84	0.70	-5.03	2	10	2012-10-11 20:44:45	2006-08-21 11:55:36	6	1	9	49	3	12	3	256.50	73	99.34	CHANGED	SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKpPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKpRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVD.ELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL	........SFhKsIYp-INspLlGppVP+Pp...SGTLSGHAAGEPFEKLVYpFLK+pLsDhTFKQYEYLNDLahKNPslIGHEARhKLFNSPTLLFLLSRGKsATcKWSIEN.FEEKQNDTADILLVKDpFYELLDVKTRNISKSAQuPNIISAYKLAQTCAKMIDNcEaDLFDINYLElDW.ELss--.LlChSTaFAELFKSpPS-LYINWAAAMQIQFHVRDLDQtFsGTREEWA+uYLKHFVsQAcpRAssMIsKFVKPFcKYIl.	0	1	3	3
+9059	PF09227	DUF1962		Domain of unknown function (DUF1962)	Sammut SJ	anon	pdb_1uoy	Domain	Members of this family of fungal domains are functionally uncharacterised [1].	21.30	21.30	21.80	118.50	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.42	0.72	-3.93	3	8	2009-01-15 18:05:59	2006-08-21 12:10:45	5	1	7	1	4	7	0	65.20	70	72.20	CHANGED	DTCGSGYGGDQRRTN......SPCQuuNGDRHFCGCDRTGVVECRGGKWTEIQDCGSSTCHGTNDGGAsC	DTCGuGYGGDQRRTN......SPCQAuNGDRHFCGCDRTGVVECRGGKWTEIQDCtuSTCHGTNDGGApC	0	0	1	4
+9060	PF09228	Prok-TraM		Prokaryotic Transcriptional repressor TraM	Sammut SJ	anon	pdb_1us6	Domain	Members of this family of transcriptional repressors adopt a T-shaped structure, with a core composed of two antiparallel alpha-helices. These proteins can be divided into two parts, a 'globular head' and an 'elongated tail', and they negatively regulate conjugation and the expression of tra genes by antagonising traR/AAI-dependent activation [1].	21.40	21.40	22.00	22.60	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.17	0.72	-3.87	14	32	2009-09-10 15:54:28	2006-08-21 13:14:02	5	1	24	12	10	38	1	100.10	36	95.07	CHANGED	Mphtsospss......sEtcshtuhhsuhpcu-LEsLsluAIR-HR+Llsts-slap-h..ussDspsusushpshptEYlptphcpcAQQptLosll-hLGalPcV	................Mp..sus.ss.....tsEh+shhuhhpulspu-LEsLolsAIRpHRpLltpA-pla.pt...hs-c.psupushts.phcYlctphchcAQ.ptlssllshLGalPcV...........	0	1	4	7
+9061	PF09229	Aha1_N		Activator of Hsp90 ATPase, N-terminal	Sammut SJ	anon	pdb_1usu	Domain	Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity [1].	22.50	22.50	23.00	23.00	21.30	20.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.58	0.71	-4.34	69	522	2009-01-15 18:05:59	2006-08-21 13:38:25	6	16	302	7	363	496	9	134.10	25	44.42	CHANGED	-KsstsWu+phlcphlss.....lp..h.psssh............................php...lsclsp..lcG.-usVspRK.GKlIsha-hclphpapGp....................tspst................hpGplplP-lup-.s..-t--hph.pl............shp.scssptp.....hcsll+pphhsp..l+ptltpahpcLhtp...up	.................................................-KssssWu+phlcp.h.Lhs.......lp.....s..p.ssss............................................psclsc..lpp.l-G.-us.lspRK.G..KlIhha-.hp.lpLpapGp......................................................................spss................hpGplplPpluc-.s...c.--h...ph...pl...................................sht...ps.p..s.ptp.........lcshh.+.pp...h..h...sp...l+ptltpahptLhtpa....................................................................	0	116	202	295
+9062	PF09230	DFF40		DNA fragmentation factor 40 kDa	Sammut SJ	anon	pdb_1v0d	Domain	Members of this family of eukaryotic apoptotic proteins induce DNA fragmentation and chromatin condensation during apoptosis [1].	25.00	25.00	52.10	36.10	23.10	23.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.69	0.70	-4.99	9	108	2009-01-15 18:05:59	2006-08-21 14:03:21	5	3	71	1	54	108	0	223.70	45	71.91	CHANGED	tllptAcpLloD-cuPcpp+lLushlpslp-phptEsR--DscWFEGl.-spF+oKpshM+hsspSRIRGYhpcscshhops....tsspA+c.hpchL-thpppLpuscY.ushFDRu.tctt.......................................................RLCTs-GWFoCQGsFDps..sCsttHoINPYusREuRILFSTWNLDHhIEK+RoVlPulscAlcc.h...............cG+clshtYFYpLLFThpNLKLVHIsCHcKssHcLp......CDps+hY+	..........h...pthcphls-.pt.ppp+lLssh.........ppphthpp+sEcspWFcGh..EpR.F+oKpthhphpspoRlRuYhhcspp.hops.......sscA+p.h.pllpthp.hLpuscY.u.aFDRs.tptt.......................................................................................spLCospG.FpCQGsasts..sC.....p..p..HoINPYusREshILFpTWNL.DHhIEhpRTllPsLst.slcc.................pst-lsh..aa..LFThcNLKLVHIsCHcKspHp.t......Cs.pc.Yp.........	0	11	15	32
+9063	PF09231	RDV-p3		Rice dwarf virus p3	Sammut SJ	anon	pdb_1uf2	Domain	Members of this family are core structural proteins found in the double-stranded RNA virus Phytoreovirus. They are large proteins without apparent domain division, with a number of all-alpha regions and one all beta domain near the C-terminal end [1].	25.00	25.00	1167.80	1167.60	18.80	18.40	hmmbuild  -o /dev/null HMM SEED	965	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.57	0.70	-7.14	2	12	2009-09-10 17:20:48	2006-08-21 14:21:20	5	1	4	2	0	14	0	964.70	62	94.51	CHANGED	pSVVSRsPlPlShhslS-lpKLFDI.sIppGSohpIV-cPQsoFhlphtcshascahCl-H.sAaEPuLhhHRl+hlaShLscYsuphISEVPh.sshlsph.VpslshsKhsDRNMsshAE+L.h-.-VhsApp-.hh.Y.RpSsstsPlTFtDDL..sVRERssLY+RY.VPap.lELuLashA.phLslQYCHPhlVYpYLpsRAPsFLhlsDQluLchhSAG.GpLhPRPVhplLDYsLVY.SPLALNNLuShLhp+Iphplhhp.lstVppsLuElVssSSsVoNsASuslspMNVtGVpTlAsFIhpShLNPNISYuhlutLsLDsFssFIYGsCLhLhQAlhPPSAlsAhpRlcINNthAYFLl+hhssQsshspll.NplI.slssh.pWpSscRDlLsAIYsNLhsu-hhl.NLlppYaRtsssppsspl.lPAcpTSYGhNETRulShPYLFGssIs.htPDsRLssYKpcLsLPsRSPILIsss.tpNslslp.lphKhshIhshY..NsFVppPstWlRNusSNoALLu+FhDsssNlhGIhEslLuNsYuNAVNsYCDSVYRAslPhpWKh+.slDPpDhhFslFGlsPpY.lhs-ulPDFFAGuEDILILQLlRAla-shSN+hGpsPschF+h--V.KslpEhVSlllppKlDsp+YFT-sMRSsoFSK.tW-pFltR.VupcLPsL.psIhsQs-pl.NYMsQhhtIhPIsDpFYlV+NSGhssRGSssPlhAuool..N.lpsshhItDapthstLhhppcpVD.so.ps.hps.F.tLppIuSsEFVRSs...pucshFT-..l-AI+VNMhs+a-LphhpEpGtaSKPsplpKlMapDhhSFlcSphuchhPPlhTlPIsIhLNsLGEssSsphRMRS.tlDEYFpsasGAQlllPlshVshchhsphp-LpshFsGsVslp.cPa.lh-shcssYl.hGsHtVhlDP	..SsVSRVPLPVSFluhpDVc+lFcIIPl+hGSTohIlDpPpVsFllhYs-sIYDDFMpIcplsAFEPSlTMHRVcslFSlhpKYCsSMlstVPThSohVu-lPVKuVTMScFGDRsMDpLApaLspEhElluAQtpNRthYVRouA.-VPhsFGDDLssAshERtN.YHpYpVPFHslELALYpLAs-LLchQYCHPTVshcaLpcRAPPFLsV-DpVu.+MhpAGsGsLMPRPVMELLDYoLVYpSPLALspLAoRL.SKISl+L+MRMVTEVQpolS-hluVSSosSs.uoSuItshNlhGVEsLslahARSlLNPNhuYA.IScLTh.AFpDFlYGoCLLLlQAhlPPSAIhApsRlhINNRLAYFLIRYIAh.ATYsRLssNpVlPphhNpDcWQ.sshDhLVAIYoNLLsGEtRLsplIphYFRGpsP.tVstIsIPAsQTuYtIsEppuISAPYLFGAPINtMAPDsRL.-aKpsLNLPPRSPIL.TNlEGsNVISLpNLhsKsDlIpAlY.LsGFs+.oPuhWIRNAu.NTAhLoKhlssVSNLouIYEAVLANTYANAlNVYCDo.Y+s-IPLNWKl.hoIcPKDhLFuVFGllPhYQL.sEAVPDFFAGSEDILILQLIpAVYchLup+LGssPTpaFHLEEVhpslScIVSILsppplDV+hYFTDS.+ShTFsKPhWDRFIRRs.ttpLPPLYclIhpQlssVYshhptMpcllPIsDaFYIsRNsGaVARGSopsIlAATSlYpNQhsVpppIssFo-AssLRLptRRVDNsShTosL-DMFYsLSSISSsEFVRSstRGcop.+hss..VssIKVNMRARYsLpIhTE-Gsh.+.PclKKhMaSDFlsFLhpHpp-P+sPllpIPITIGLNNlGtTTSTslR.cScsVDEYFKuYlGAQVlIPhDslslEplGSFsELRNhhossVVsRDKsW-IWssV-AoYVPIGNHsVpLDP	1	0	0	0
+9064	PF09232	Caenor_Her-1		Caenorhabditis elegans Her-1	Sammut SJ	anon	pdb_1szh	Domain	Her-1 adopts an all-helical structure with two subdomains: residues 19-80 comprise a left-handed three-helix bundle with an overhand connection between the second and third helices, whilst residues 81-164 comprise a left-handed anti-parallel four-helix bundle in which the first helix consists of four consecutive turns of 3-10-helix. Fourteen Cys are conserved in all known HER-1 sequences and form seven disulfide bonds. The protein dictates male development in Caenorhabditis elegans, probably by playing a direct role in cell signaling during C. elegans sex determination. It also inhibits the function of tra-2a [1].	19.80	19.80	45.60	45.40	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.05	0.71	-4.10	2	15	2009-01-15 18:05:59	2006-08-21 14:35:42	5	1	8	2	13	10	2	114.70	37	68.76	CHANGED	CCo.phhECCh-.lpFupPl+Cs.thcLth.h.Vh.ChQpELau.E.p.hhNLsDoVCCsVFupD.ND.pchC.o.ChTsMQ.PuLcsspKLp+IK-Cp.ppNsLYpCFs+C..hh+pchc.EshcFpp.Cs	.CCstpthcCCh-uIcFsh.lpCs.thphtt..hpshpClQpELauccs....hhslschsCCsVFtsD.sDspthChptChpsMpuPSlcussKLppI+pCp...hsNsLapCFppCpthhc.pt.c.Eshphpp.Cs.................	0	8	9	13
+9065	PF09233	Endonuc-EcoRV		Restriction endonuclease EcoRV	Sammut SJ	anon	pdb_1sx5	Domain	Members of this family of prokaryotic restriction endonucleases recognise the double-stranded sequence 5'-GATATC-3' and cleave after T-3. They catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates [1].	25.00	25.00	35.50	34.70	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.62	0.70	-5.02	3	40	2012-10-11 20:44:45	2006-08-21 14:45:55	6	1	39	61	7	49	8	236.60	41	89.70	CHANGED	SsLlscIpDsNppWcVKGFIDu-s+IYoLSsDTKVISKILEIalFPhIpcFAccHcFpVlLPKcQNaYPDlSFlc.K-SscKIAIDIKTTYRNccNsK..sGFTLGuaTuYFRNRpSsKNIsFPYc-YluHalLGlVYTRVssRlDELKpYsIsELs+I.SVIKslclFLQEKYKIAoDpuGSGNTsNIGSI+.+h-Dll-GKGIFuchGE-lFDDYWhNYpphsh.psSQL+scsYsNISEY..apYR.G+	..........ht....t.lssptscWpl+GFIDhpKsIYTIouDTKllSKIlElhlFPt.lppFAccpGaclhhsppQNaYPDloFhs.....pssshKaAlDIKTTYR...pscs.s.....sGFTLGSasuYFRNRpusKNIpaPYscY.uHasLGllYoRs.s.p.p.h.-.Ep.chhsl-cLcpIsSVl+shpFFlpEKWKIASD+sGSGNTsNIGSIp..pIccllpGpGhFssL....GE-..lFD-YWh.N.a.shh.h...ptphphp.hssLtpa..hta....h.............	0	1	5	6
+9066	PF09234	DUF1963		Domain of unknown function (DUF1963)	Sammut SJ	anon	pdb_1pv5	Domain	This domain is found in a set of hypothetical bacterial proteins. Its exact function has not, as yet, been described.	21.80	21.80	21.80	22.30	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.82	0.70	-4.11	34	835	2009-01-15 18:05:59	2006-08-21 15:34:19	5	12	604	1	134	636	11	217.00	27	78.00	CHANGED	SKhGGp.PalPps...paPp..............s.ppG.........p.PhhhLAQlNhs-ls.....p.lpsa..P.pp...GlLpFFls..p..........psppps..shcVhah-phtppp.....ppl.p-hshhp.h.........h.tthpl...p.p..........sl..pshphpp.ht..h.p...........cpppchhcchh-.h...........tps...p+..lGGYP.asQ............................ps.+pttc...........................pphhLLhQ..lDo-......tphshhaGDs.Ghh.FaIpcpDLtshcFsplhhsasC	......................................................................................................SKhGGh.PhLPtt...hcaPh......................................................................s..pps......................PhhhlAQl.Nhs.-ls..............t...p.a......P...pp.......GlLp.Falstps.................p...s.spt....shRll...Yhpp.hpph.h..........ppl.schp.hstt...........................httthplth..p.t.......................psl...p.s.hchpp.h.......ch.......................tt.pphhpt.l.hpph..................pt...hpp......lGGYPhasQ..............................................................-scp.pp..........................ttt.h...l.LhQ....lDSs.............sshshhWGDh...G.hstah.IpppDLtshcFsphhhshp..............................................................................................................................................	1	52	91	117
+9067	PF09235	Ste50p-SAM		Ste50p, sterile alpha motif	Sammut SJ	anon	pdb_1uqv	Domain	The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerisation and heterodimerisation (and in some cases oligomerisation) of the protein [1].	20.90	20.90	20.90	21.10	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.55	0.72	-3.95	3	28	2012-10-02 20:42:54	2006-08-21 16:06:02	5	2	27	2	16	31	2	73.20	54	22.58	CHANGED	-sFscWSTDEVlpWCtosLGl-EsDPLhpR.IRENcIsGSlLsELTLQDCKELCDsDLscAIKLKlhINKhlDScL	.........-DFopWSVDDVloWClSoLEl-E.s..DP.LCp+....LRENDIsGDLLPELsLpDCp-LCD.uDLs+AIKFKILINKhpDoc.................	0	1	6	13
+9068	PF09236	AHSP		Alpha-haemoglobin stabilising protein	Sammut SJ	anon	pdb_1w09	Domain	Alpha-haemoglobin stabilising protein (AHSP) acts a molecular chaperone for free alpha-haemoglobin, preventing the harmful aggregation of alpha-haemoglobin during normal erythroid cell development: it specifically protects free alpha-haemoglobin from precipitation. AHSP adopts a helical secondary structure consisting of an elongated antiparallel three alpha-helix bundle [1].	20.50	20.50	21.10	20.70	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.94	0.72	-3.78	3	32	2009-01-15 18:05:59	2006-08-21 16:22:21	5	1	27	10	16	34	0	85.80	62	82.00	CHANGED	QoNKDLISsGIKEFNVLLNQQVFsDPLISEEDMVTVVcDWVNFYINYYKKQVoGEQ-EQDKALQEFRQELNTLuusFLAKYRsFLKS+E	................puNKDLISsGhKEF....slLLNQ.........QVFsDPl.lSEEcMVTVVcDWhNFYINYY+pploGEpQEpD+ALQELpQ..ELNTLusPFLsKYRsFLKSp....	0	1	1	3
+9069	PF09237	GAGA		GAGA factor	Sammut SJ	anon	pdb_1yuj	Domain	Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].	20.20	20.20	20.20	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.75	0.72	-4.37	3	58	2012-10-03 11:22:52	2006-08-21 16:35:59	6	13	44	2	38	74	1	48.30	47	10.02	CHANGED	stsshhc+hsGllKIKSKSQSEQPATCPICQAVIRQSRNLRRHLELRHFKKPGV	...........................................+s+upS.-pPuTCPlCtAllRQSRNLRRH....LElpHh....................	0	7	11	31
+9070	PF09238	IL4Ra_N		Interleukin-4 receptor alpha chain, N-terminal	Sammut SJ	anon	pdb_1iar	Domain	Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response [1].	22.90	22.90	23.70	26.10	22.50	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.32	0.72	-3.88	7	71	2009-01-15 18:05:59	2006-08-22 09:17:01	5	2	37	4	27	64	0	90.20	45	18.27	CHANGED	+VLp-PsCFSDYIpsSTCEWchsussNCSupLpLsYpL..F.hSENh.TClPENpu...uoVCVC+Mhh-p.VpsDsYpL-LWAspp.LWpuSFKPSppV	....chlp-.sCaSDYhut.TCcWKhsussNCSs.-LpLhYpL..a.......s...csh.oCVPENst......uus......ClC+lhh-shVssD.YpLcLauGppl...LWp.u.SFpPuppV.............................	0	1	6	10
+9071	PF09239	Topo-VIb_trans		Topoisomerase VI B subunit, transducer	Sammut SJ	anon	pdb_1mu5	Domain	Members of this family adopt a structure consisting of a four-stranded beta-sheet backed by three alpha-helices, the last of which is over 50 amino acids long and extends from the body of the protein by several turns. This domain has been proposed to mediate intersubunit communication by structurally transducing signals from the ATP binding and hydrolysis domains to the DNA binding and cleavage domains of the gyrase holoenzyme [1].	20.50	20.50	21.20	28.80	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.93	0.71	-4.70	36	213	2012-10-03 01:04:38	2006-08-22 09:42:12	6	7	190	20	129	216	138	155.40	40	26.23	CHANGED	Ps.sssLSPIGE-hIcpGLcc....hps-Fluu.lTRpPpsYuGp.PFlVEsGIAYGGcl...sps..psplhRFANRlPLLYcpGuCslTc.slc..slsW+pYslcpst......uPlllhVHlsSTpVPapSsuK-uIA....-lPEIccEl+lAlpcsuRcL+paLs++c+tcctcc+	........................PssssLSPIG--.lctGlcc....hp.P-.Flss.hT........RpPpsYpGp.PFlVEsGlAYGGcl.....................spp........phplhRFANRlPLLa-pGusslTc.s...lc..plsW+p.Ytlcpst......uPlslhVHlsSTplPapStuK-uIA....clsEItcEl+hAlpcsuRcLcpals++cptpctpc+.............................	0	41	82	109
+9072	PF09240	IL6Ra-bind		Interleukin-6 receptor alpha chain, binding	Sammut SJ	anon	pdb_1n26	Domain	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6 [1].	23.10	23.10	23.20	23.10	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.63	0.72	-3.83	23	523	2012-10-03 16:25:20	2006-08-22 09:59:09	5	17	48	40	212	691	0	94.90	22	19.27	CHANGED	ssp..sLpChh+s...........hphlpCoWpsGtsssssspYsLaahapshppstp.....Cppahpsp.t.........phuCphsh.ph..sthp......pahlpVsuoSpsuslpst.pshphpsl	....................sp.slsChhps............hphhpCoWpsGp..s..ss...s..T.pYsLahph.ps.....p..pt.pp.......Cpph...hpsp...t............phuCphsh.p..h..p..ht......phhltlpspsttt.lps...hh......................................................	1	12	21	54
+9073	PF09241	Herp-Cyclin		Herpesviridae viral cyclin	Sammut SJ	anon	pdb_1bu2	Domain	Members of this family of viral cyclins adopt a helical structure consisting of five alpha-helices, with one helix surrounded by the others. They specifically activate CDK6 of host cells to a very high degree [1].	25.00	25.00	217.10	216.80	23.60	18.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.52	0.72	-3.75	3	3	2009-01-15 18:05:59	2006-08-22 10:12:15	5	1	3	5	0	5	0	106.00	81	41.30	CHANGED	AVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL	AVLATDFLIPLCNALKIPEDLWPQLYEAASTTICKALIQPNIALLSPGLICAGGLLTTIETDNTNCRPWTCYLEDLSSILNFSTNTVRTVKDQVSEAFSLYDLEIL	0	0	0	0
+9074	PF09242	FCSD-flav_bind		Flavocytochrome c sulphide dehydrogenase, flavin-binding	Sammut SJ	anon	pdb_1fcd	Domain	Members of this family adopt a structure consisting of a beta(3,4)-alpha(3) core, and an alpha+beta sandwich. They are required for binding to flavin, and subsequent electron transfer [1].	21.50	21.50	22.20	21.50	20.20	21.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.37	0.72	-4.02	53	230	2009-09-11 08:59:02	2006-08-22 10:22:50	6	6	178	2	112	249	205	70.00	30	16.54	CHANGED	Pss.shhsNTCYSllu..PchuloVAuVYchsssp..lhslpG.......loshssssshpppEAphAhuWYpsIopDhaG	..........shhsNTCYShlu..scpulpVuulYchsssp.....lsplsG.....hhpsss...tsss.hp.ptcuphAhuWhpsIhsDhaG.........	0	28	69	89
+9075	PF09243	Rsm22		Mitochondrial small ribosomal subunit Rsm22	Mistry J, Wood V	anon	Pfam-B_8789 (release 20.0)	Family	Rsm22 has been identified as a mitochondrial small ribosomal subunit [1] and is a methyltransferase.  In Schizosaccharomyces pombe, Rsm22 is tandemly fused to Cox11 (a factor required for copper insertion into cytochrome oxidase) and the two proteins are proteolytically cleaved after import into the mitochondria [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.89	0.70	-5.37	7	679	2012-10-10 17:06:42	2006-08-22 11:14:57	5	14	492	0	408	777	58	228.70	20	53.83	CHANGED	chsshAYhAtRhPuTYAAV+uuLcuhApusPpFsPtShLDlGuGsGsuhWAssphWs.chppshhl-tStshhslGpplAtcssthppshhttshhhthlph..s.....DLVTluYVLsELss.spRptll-pLWstssp..hlVIVEsGTPsGapRll-ARctL....IAtGh+lsAPCPHshsCPlsss....DWCHFStRVu..RSplHRhsK....suplsaEDEKFsY..lAAsRtssuss...............ssRVltPPpltuG+VllcLCppDtphpcplsTK.R..............cG.tha+tARcucWGDta.	....................................................................................................................................t.....ah.......a...t.h.t.h.th....................................t......h..................s.t........p...h.h.DhGsG..........u.s...s...h.....h...........sh.......t....t....h..........h......t....................h...................p.................h............h.......h...l...-..........s........h........t.....hu.t..l..h....t....t.........................................................................................h....t..........................................Dll.hhsas.L....c......l...........................t.............t......c.........t.......t........h......lpph..h..t..h..h.t............hlll...lE....Gs.t..G.aphl.h..ts.Rphl................................tt.....h.hlhAPCsp..t..............C.....P.h......................................C.p..F....t..h..........................................................pt.....t..asa....l....h....h..p....................................................................................hsRlh...s.h.tttth.hphC......t...................tt........h...tt...hst..p...........................................t.......a.....h+....Gs.................................................................................................................	0	139	251	353
+9076	PF09244	DUF1964		Domain of unknown function (DUF1964)	Sammut SJ	anon	pdb_1r7a	Domain	Members of this family of bacterial domains adopt a beta-sandwich fold, with Greek-key topology. They are C-terminal to the catalytic sucrose phosphorylase beta/alpha barrel domain, and are functionally uncharacterised [1].	21.80	21.80	24.00	73.30	21.70	16.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.40	0.72	-3.64	3	41	2009-01-15 18:05:59	2006-08-22 11:24:14	5	1	40	6	7	34	4	68.70	68	13.57	CHANGED	AFDG-FSYoVDDDTSIoFoWsGt..TSpATLTFEPuRGLGVDNsTPVAoLsWoDSAGDHRTDDLIANPPV	AFDG-FSYpsDGDTSIoFpWpus..sooAsLTFEPG+GLGsDNsssVAoLsWoDuAGDHcTDDLlANPPl.	0	1	2	3
+9077	PF09245	MA-Mit		Mycoplasma arthritidis-derived mitogen	Sammut SJ	anon	pdb_1r5i	Domain	Mycoplasma arthritidis-derived mitogen (MA-Mit) adopts a completely alpha-helical structure consisting of ten alpha helices. It is a superantigen that can activate large fractions of T cells bearing particular TCR V-beta elements. Two MA-Mit molecules form an asymmetric dimer and cross-link two MHC antigens to form a dimerised MA-Mit-MHC complex [1].	25.00	25.00	62.90	62.70	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.65	0.70	-5.06	2	5	2009-09-11 16:59:48	2006-08-22 11:50:13	5	1	2	8	2	9	0	165.60	79	87.34	CHANGED	SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNKEETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNMMFLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLSYFISQNKNFQELWDKAVKLTKEMKIKLKGQKL.............................................................D	SMKLRVENPKKAQKHFVQNLNNVVFTNKELEDIYNLSNK.EETKEVLKLFKLKVNQFYRHAFGIVNDYNGLLEYKEIFNMMFLKLSVVFDTQRKEANNVEQIKRNIAILDEIMAKADNDLSYFISQNKNFQELWDKAVKLTKEMKIKLKGQKLDhhDs.sslNpVcchFGuDcsVKplhWF+SLLl+us.hlh+YY-us..hpspoDFtKAlFE..	0	0	2	2
+9078	PF09246	PHAT		PHAT	Sammut SJ	anon	pdb_1oxj	Domain	The PHAT (pseudo-HEAT analogous topology) domain assumes a structure consisting of a layer of three parallel helices packed against a layer of two antiparallel helices, into a cylindrical shaped five-helix bundle. It is found in the RNA-binding protein Smaug, where it is essential for high-affinity RNA binding [1].	21.50	21.50	21.60	23.90	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.48	0.72	-4.44	4	24	2012-10-11 20:01:01	2006-08-22 12:56:51	5	1	23	1	19	32	0	110.20	45	11.80	CHANGED	RhslL.RlEpDLl..uGQ.hpLSTslEELTNIVLTPMKPlt.stP..EsIutpFlKVlDLVushl.tcPhC.sQD-EshsVFhWIL-RulHN-AFhsHusQLK-hKaKlSKl	................................RhphL.+lEp-Lh...........sGp.hp....LusslEELTNIVLTPMKPl.......ps.ssP....EsIuhpFlKVlDlVs..stLtt-Phs.sQDDEsLsVahWIL-RulHN-AFhsHssQLK-hKaKlsKh.............	0	4	5	16
+9079	PF09247	TBP-binding		TATA box-binding protein binding	Sammut SJ	anon	pdb_1tba	Domain	Members of this family adopt a structure consisting of three alpha helices and a beta-hairpin. They bind to TATA box-binding protein (TBP), inhibiting TBP interaction with the TATA element, thereby resulting in shutting down of gene transcription [1].	25.00	25.00	25.20	25.20	23.90	24.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.95	0.72	-3.76	8	130	2009-01-15 18:05:59	2006-08-22 13:12:45	6	18	84	1	77	139	0	63.20	49	3.73	CHANGED	SDuDs-p-s....shsLsGFLFGNIDpsGcL-sDsh........LDcEuKcHLuuLuchGLuShLsEl........hssc-t	...........sp-p-t-p.........shs.LsGFLFGNIspsGpLEsDsl........LDs.......EsK+HLAuLu.s.L.GLGSLloEl........sus--....................	0	21	33	53
+9080	PF09248	DUF1965		Domain of unknown function (DUF1965)	Sammut SJ	anon	pdb_1n9e	Domain	Members of this family of fungal domains adopt a structure that consists of an alpha/beta motif. Their exact function has not, as yet, been determined [1].	29.20	29.20	31.50	30.20	28.40	29.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.44	0.72	-4.07	7	53	2009-01-15 18:05:59	2006-08-22 13:32:51	5	7	42	7	41	57	0	73.70	35	9.63	CHANGED	FDspoLlPhGLaFpSDlTGRDPSpWpL.GWlYNshFYpTTEEFRpAaaSssFsKhtPNl-...GsWutTDppGsl.P	..........sLlPlGLahthDlTGRDPSp..WplhGalYsspFYpTs-cFRpAahsssF.p+.h.ssshs....GsWutpsppGp..........................	0	16	26	36
+9081	PF09249	tRNA_NucTransf2		tRNA nucleotidyltransferase, second domain	Sammut SJ	anon	pdb_1r89	Domain	Members of this family adopt a structure consisting of a five helical bundle core. They are predominantly found in Archaeal tRNA nucleotidyltransferase, following the catalytic nucleotidyltransferase domain [1].	21.90	21.90	21.90	22.10	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.60	0.71	-4.20	41	166	2009-09-11 09:45:38	2006-08-22 13:58:42	6	5	161	44	104	174	43	112.60	42	25.93	CHANGED	D-VRLLKpFhKulGVYGuEl+spGFSGYLsELLllpYGuFpslLcuAu.pW+s.shhI-hp.......p.hcpF............ccPLlVlDPVDPpRNVAAAlShcshupFlhtuRtFL.cpPShsaFhs	...................--VRLLKpFhKulGlYGuEl+spGFSGYLsELLllcYGuFpslLcsAu.pW+..shhI-hp............t..p..ppF...............ccPLlVlDPVDPpRNVAAulShcshupFhhtu+paLc.pPuhpaFh.....................	0	26	61	84
+9082	PF09250	Prim-Pol		Bifunctional DNA primase/polymerase, N-terminal	Sammut SJ	anon	pdb_1ro2	Domain	Members of this family adopt a structure consisting of a core of antiparallel beta sheets. They are found in various bacterial hypothetical proteins, and have been shown to harbour both primase and polymerase activities [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.83	0.71	-4.26	98	956	2009-09-11 10:28:24	2006-08-22 14:21:46	6	32	635	4	284	971	283	175.10	18	37.07	CHANGED	Ahthh.pp.GhsVhPl.....................sssKpPh................................hpsappss.p.....c.pplpp..hap......t.......................................shslulhs.............ssllllDlDsps...............................slpthtt..........thlss.....sh......sspT....sps.................GtHhaaphsss..............htt......................t..lD....l.tsss.sa............l..ls.......s.......PShp....sss....Yp......hh.....................................hsshP...........thL	............................................................hh.tt.Ghs.lh..Ph................................s.ssKtPh.....................................................hpshp.pso..s..............s.p.plpp...ahp...ph.....................................ssss.lulhs......................t.sshhllDlDsts..........................s.t...................................slpphtp...........h.hthlss.......sh..sstTsss......................................Gt.Hha.ap..h..stsh........h.pphhhh...........................................su...l-....l..p....u.p...s...sa............l..ls..s..PSht.............sts.....Yp.........h.tt...............................................................................................................	0	86	198	257
+9083	PF09251	PhageP22-tail		Salmonella phage P22 tail-spike	Sammut SJ	anon	pdb_1tyv	Domain	Members of this family of viral domains adopt a structure consisting of a single-stranded right-handed beta-helix, which in turn is made of parallel beta-strands and short turns. They are required for recognition of the 0-antigenic repeating units of the cell surface, and for subsequent infection of the bacterial cell [1].	25.00	25.00	127.50	127.30	18.20	17.40	hmmbuild  -o /dev/null HMM SEED	549	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-12.76	0.70	-6.24	6	48	2012-10-02 14:50:22	2006-08-22 14:45:56	5	2	44	23	0	51	0	509.60	79	82.26	CHANGED	phEADKKFKYSVKLSDasTLQshAsAAVDuLLIDlDYpFoNGETVDFGGKsLTIDCKAKFIGDGNLlFTpLGpGSlVtuPFMESsTTPWVIhPWT-DspWITDAAAVVATLKQSKT-GYQPTVNDYVKFPGIEoLLPspAKsQsIsSTL-IRECoGVEV+RASGLMAsaLFRuCHaCKMlDuDs..GGKDGlITFENLSGDWGhGNYVIGGRTsYGSVSSsQFLRNNGGhu+DGGVIGFTSYRAGESGVKTWQGTVGuTTSRNYNLQFRDSlsL.PVWDGFDLGADssMsPEsDRPGDaPlSQYPlHQLPhNHLIDNLLVhGSLGVGlGMDGpGhYVSNITVpDCAGSGuhhhTappVFTNIulIDTNThNFsAsQIYIpGsChVNGLRLlGI+sTsupGhsIDAPNSTlSGITG.VDPSRINVANLh-.sLGNoRINSFNsDSAuLclRIHKLSKTLDSGAlhSHlNGGsGSGSAWTElTAISGSsPDAVSLKlNRGDaRAsEIPlusolLPDsAV+DpuohuhYhEss..SLKALVK+sDGShTRlTLA	........SIEADKKFKYSVKLSDYsTLQDAASAAVDGLLIDlDYpFYsGEpVDFGGKsLTI-CKAKFIGDGNLIFTKLGKGSRIAGVFMESTTTPWVIKPWTDDNQWLTDAAAVVATLKQSKTDGYQPTVSDYVKFPGIETLLPPNAKGQNITSTLEIRECIGVEVHRASGLMAGFLFRGCHFCKMVDANNPSGGKDGIITFENL.SGDWGKGNYVIGGRTSYGSVSSAQFLRNNGGFERDGGVIG.FTSYRAGESGVKTWQGTVGSTTSRNYNLQFRDSVVIYPVWDGFDLGADTDMNPELDRPGDYPITQYPLHQLPLNHLIDNLLVRGALGVGFGMDGKGMYVSNITVEDCAGSGAYLLTHESVFTNIAIIDTNTKDFQA.NQIYISGACRVNGLRLIGIRSTDGQGLTIDAPNSTVSGITG.MVD.P.SRINVANLAEEGLGNIRANSFGYDSAAIKLRIHKLSKTLDSGALYSHIN.GGPGSGSAaTQLTAISGuTPDAVSLKVNHpDsRuAEIPFsPslsSD-hlKDuSCFlPYWEsN.sSLKALVKKPNGpLVRLTLA.......	0	0	0	0
+9084	PF09252	Feld-I_B		Allergen Fel d I-B chain	Sammut SJ	anon	pdb_1puo	Domain	Members of this family of cat allergens adopt a helical structure consisting of eight alpha helices, in a Uteroglobin-like fold. They are one of the most important causes of allergic asthma worldwide [1].	24.00	24.00	25.10	24.80	22.80	21.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.03	0.72	-4.07	10	38	2012-10-01 20:54:19	2006-08-22 16:24:57	5	1	15	6	15	64	0	66.30	42	64.32	CHANGED	ClPFFcuYuuVloGu+laLpp-LStFNATstE+sAaEKIQDCapEpGlKoKlL-splMtollhSsEC	.................ChsFassYsullsGs+hhLptpLuhFsATssE+sAaEKIQDCasEpGL+sKlh-splMholhhSsEC.....	0	0	0	0
+9085	PF09253	Ole-e-6		Pollen allergen ole e 6	Sammut SJ	anon	pdb_1ss3	Domain	Members of this family consist of two nearly antiparallel alpha-helices, that are connected by a short loop and followed by a long, unstructured C-terminal tail. They are highly allergenic, primarily mediating olive allergy [1].	25.00	25.00	28.90	28.90	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.46	0.72	-4.31	3	13	2009-01-15 18:05:59	2006-08-22 16:37:14	5	1	7	1	7	14	0	39.50	54	51.09	CHANGED	CYDsCQKECSDcGsGYTFCEMKCDsDCosK-lKEKIENL..Kp	CFssCccECpscGsG.TFCEMKCDTDChsK-lttKl......h........	0	0	5	7
+9086	PF09254	Endonuc-FokI_C		Restriction endonuclease FokI, C terminal	Sammut SJ	anon	pdb_2fok	Domain	Members of this family are predominantly found in prokaryotic restriction endonuclease FokI, and adopt a structure consisting of an alpha/beta/alpha core containing a five-stranded beta-sheet. They recognise the double-stranded DNA sequence 5'-GGATG-3' and cleave DNA phosphodiester groups 9 base pairs away on this strand and 13 base pairs away on the complementary strand [1].	25.00	25.00	25.00	25.20	23.60	24.30	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.96	0.71	-5.20	12	30	2012-10-11 20:44:45	2006-08-22 16:55:39	6	3	30	3	5	37	1	174.70	34	34.62	CHANGED	KsslpchKsclRcclsplsHcYLpLlDlAaDuK....pNR-...FEhhTh-Lhhp.hsFcGh+LGGoRKPDGllYpssh....GlIlDTKAYupGYsLsIsQADEMhRYl--NppRDcphNPN+WWEsFscsl..pp.ahFlaVSupFhGsFpcQLpphspcTsspGuAlsVppLLLhA-hl+sGchshp-hhchhpNs-Ihh	..........................phKt.hhpp.pplshpYlphl-lAacu+.....cs.p-...FEhhTh-LFps.htapup+LGG.u...pKPDsllassct....ulIlDoKAYucGYslshspsDcMh.RYIcpsppRccphsPs.WWc.asppl..sp.haFhalSupFsupacpQLpphspcTshpGuAlsVtpLLlhA-phpptphshcclhchhpsppl............	0	3	3	5
+9087	PF09255	Antig_Caf1		Caf1 Capsule antigen	Sammut SJ	anon	pdb_1p5v	Domain	Members of this family are predominantly found in the F1 capsule antigen Caf1 synthesised by Yersinia bacteria. They adopt a structure consisting of a seven strands arranged in two beta-sheets, in a Greek-key topology, and mediate targeting of the bacterium to sites of infection [1].	25.00	25.00	27.80	27.00	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.70	0.71	-4.27	2	29	2009-01-15 18:05:59	2006-08-22 17:09:56	5	1	20	15	1	24	0	107.20	85	82.49	CHANGED	VEPARITLTYKEGuPITIMDNGNIDTELLVGTLTLGGYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQDFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ	.VEPARITLTYKEGAPITIMDNGNIDTELLVGTLTLGGYKTGTTSTSVNFTDAAGDPMYLTFTSQDGNNHQFTTKVIGKDSRDFDISPKVNGENLVGDDVVLATGSQDFFVRSIGSKGGKLAAGKYTDAVTVTVSNQ	0	0	1	1
+9088	PF09256	BaffR-Tall_bind		BAFF-R, TALL-1 binding	Sammut SJ	anon	pdb_1oqe	Domain	Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 13c, BAFF-R, are required for binding to tumour necrosis factor ligand TALL-1 [1].	21.00	21.00	21.20	22.40	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.64	0.72	-4.36	2	31	2009-01-15 18:05:59	2006-08-23 09:17:39	5	1	22	70	15	30	0	31.00	57	17.37	CHANGED	PT.Cs.sECFD.LVRpCVuCtLh+TPcst.u	....PTpCspuECFDPLVRpCVuC.cLh+T..Pcst..........	0	1	1	3
+9089	PF09257	BCMA-Tall_bind		BCMA, TALL-1 binding	Sammut SJ	anon	pdb_1oqd	Domain	Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 17, BCMA, are required for binding to tumour necrosis factor ligand TALL-1 [1].	22.40	22.40	23.40	51.20	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.15	0.72	-4.00	2	32	2009-09-10 15:58:20	2006-08-23 09:26:21	5	2	24	12	15	30	0	37.40	77	22.05	CHANGED	C.psEYFDSLLHAChPCpLRCSs..PPhTCQ.YCssSVT	.C.QNEYFDSLL+ACKPCpLRCSs.TPPLsCQRYCNAS.....	0	1	1	2
+9090	PF09258	Glyco_transf_64	EXTL2; 	Glycosyl transferase family 64 domain	Sammut SJ, Bateman A	anon	pdb_1omz	Domain	Members of this family catalyse the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate [1].	20.60	20.60	20.60	21.00	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.82	0.70	-5.22	25	640	2012-10-03 05:28:31	2006-08-23 09:38:24	5	15	149	8	394	576	20	229.70	37	40.08	CHANGED	FTlllhs.....hsRtphLh+llppl..ussshlspIlVlWss.scssPpp...........pphsssu.VPlpllc.................sppsslssRFhPassIcT-AVLulDDD.shlsss-lcFAFpVWp..sFP-RlVGassRtHh.hD...spspWsYso........paoscYSMVLTGAAFaH+hY.hpLYo...phhPpulRshVDcptNCEDIhMNFLVushTppPP....lKVs......ph+papcstsst..............suhsucss..H.htpRspClNpFuchaG..hMPLhtoph+h..ssshF	.............................................FThlhhs......hpR.psLhphlpph.............sts.s........l.ppllVlWNs...s...cssPtp........................phs..sht..lPl..hll.p..........................spp....ssl.ssRFhPa....s..........pIc....T-A..VLulDD.D..s.hl.ss.s-lpFuFpV.......Wp.........pa..P-.R.l..V.G..as..s.RhH.......h..aD...........spp...pWtYso....................pho.sphSMVL.TG...AAFaH+.hY.hh.LYo...phhPt..s.l...+s.hVDph.h.........NCEDIh..MN.FLVup...lT.tpsP......................l.K.Vs........ttpac..pstsst........................uh.tcss...H.hhpRppClNpFsp.haG..hMPLhhoph+h..-.hha.................................................................................................	0	136	195	290
+9091	PF09259	Fve		Fungal immunomodulatory protein Fve	Sammut SJ	anon	pdb_1osy	Domain	Fve is a major fruiting body protein from Flammulina velutipes, a mushroom possessing immunomodulatory activity. It stimulates lymphocyte mitogenesis, suppresses systemic anaphylaxis reactions and oedema, enhances transcription of IL-2, IFN-gamma and TNF-alpha, and haemagglutinates red blood cells. It appears to be a lectin with specificity for complex cell-surface carbohydrates. Fve adopts a tertiary structure consisting of an immunoglobulin-like beta-sandwich, with seven strands arranged in two beta sheets, in a Greek-key topology. It forms a non-covalently linked homodimer containing no Cys, His or Met residues; dimerisation occurs by 3-D domain swapping of the N-terminal helices and is stabilised predominantly by hydrophobic interactions [1].	25.00	25.00	169.00	168.80	24.50	22.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.47	0.71	-4.14	2	8	2009-01-15 18:05:59	2006-08-23 09:52:28	6	1	6	5	1	8	0	109.50	72	95.01	CHANGED	SsTuLhFpLAa.VKKlsFDYTPNWGRGsPssaIDslTFPKVLTDKtYoYRVsVsGpsLGVcssaAVpssGuQplNFLpYNpGYGlADTpTIQVFVV.PDTsN..-aIIApW	..SDTALlFpLAWsVKKLSFDYTPNWGRGsPSSaIDNlTFPKVLTDKAYTYRVVVSG+DLGV+PSYAVpSDGSQKlNFLEYNsGYGIADTNTIQVFVVDPDTGN..-FIIAQW	0	0	1	1
+9092	PF09260	DUF1966		Domain of unknown function (DUF1966)	Sammut SJ	anon	pdb_7taa	Domain	This domain is found in various fungal alpha-amylase proteins. Its exact function has not, as yet, been defined [1].	21.30	21.30	21.30	21.60	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.95	0.72	-3.90	39	219	2012-10-02 20:10:03	2006-08-23 11:03:31	6	7	96	10	148	223	0	86.70	32	16.21	CHANGED	slYpDs........sslAhRKGs.tGtQllsVLoNpGo........uusYslslss..sGasuGsslh-lloCsshTs....sssGslsVsMsu....G.P+VahPsshhtGSGLC	.................lap-s........sslAhRKGs.tGtpllsVloNtGu.s........ussaslsls.....suass.Gppls-lloCs.s..hos....sssGslsVshss....G.P+.VhhPssh.h.u.SulC.............	0	45	74	117
+9093	PF09261	Alpha-mann_mid		Alpha mannosidase, middle domain	Sammut SJ	anon	pdb_1o7d	Domain	Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase [1].	20.90	20.90	21.00	20.90	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.92	0.72	-3.77	126	2561	2009-01-15 18:05:59	2006-08-23 11:25:36	6	27	1449	64	839	2123	87	78.00	28	8.09	CHANGED	EaHpGhaTSpsp.....hK+hsRpsEphL.pssEhlsshusht........tt.........ttplpplW......................cslhlsQaHDslsGouhppVhp.Dhtpch	......................................hapGhho.S..+ht.....hKphsRcsEp.h.L....ps.s.E.LsshAtht.................................th....th.........pppLpp.h..W......................+plhhsQaHDulsGouhspVhc-hhtc..............................	0	291	479	678
+9094	PF09262	PEX-1N		Peroxisome biogenesis factor 1, N-terminal 	Sammut SJ	anon	pdb_1wlf	Domain	Members of this family adopt a double psi beta-barrel fold, similar in structure to the Cdc48 N-terminal domain. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation [1].	19.50	19.50	21.20	19.60	18.80	16.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.78	0.72	-3.93	32	271	2012-10-01 20:15:13	2006-08-23 11:53:34	6	14	244	1	190	278	1	81.00	35	7.38	CHANGED	AppVplEPlTscDWEllEhpAphlEs.plLsQlRslhs.............sphlslal..sssossplpVspltPssst..................hu+lsssoEllVAP	.....sppVplEPlos-DWE....IlELHAphlEp.pLLsQlRlV.s.............sphlslal........sssossplplsslpPsss....................hu+lsssoEllVAP...............	0	53	95	152
+9095	PF09263	PEX-2N		Peroxisome biogenesis factor 1, N-terminal 	Sammut SJ	anon	pdb_1wlf	Domain	Members of this family adopt a Cdc48 domain 2-like fold, with a beta-alpha-beta(3) arrangement. It has been suggested that this domain may be involved in interactions with ubiquitin, ubiquitin-like protein modifiers, or ubiquitin-like domains, such as Ubx. Furthermore, the domain may possess a putative adaptor or substrate binding site, allowing for peroxisomal biogenesis, membrane fusion and protein translocation [1].	25.00	25.00	29.70	32.80	21.60	20.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.94	0.72	-3.68	2	52	2009-01-15 18:05:59	2006-08-23 11:54:29	5	4	36	1	28	53	0	83.50	64	7.17	CHANGED	GAVVolthTss+DsFh+Ls.cllAQL+L.QNpAlEVu.scQ.PsYLsWhEuRphss.upNVAElNRQhupKLGhSpGpQVFL+.Cop	....ssVTVsFTNARDCFLHLPp+LVuQLHLhQNQAIEVsWucQ.PsFLSWVEGRHhocp....GENVAEINRQlGQKLGLSsGpQVFL+PCoH.....	0	3	5	12
+9096	PF09264	Sial-lect-inser		Vibrio cholerae sialidase, lectin insertion	Sammut SJ	anon	pdb_1w0p	Domain	Members of this family are predominantly found in Vibrio cholerae sialidase, and adopt a beta sandwich structure consisting of 12-14 strands arranged in two beta-sheets. They bind to lectins with high affinity helping to target the protein to sialic acid-rich environments, thereby enhancing the catalytic efficiency of the enzyme [1].	25.00	25.00	36.90	35.40	18.60	16.40	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.09	0.71	-4.98	2	111	2009-01-15 18:05:59	2006-08-23 12:46:17	5	8	55	9	4	48	0	178.40	52	44.74	CHANGED	DVTcQVKE+SaQIAGWGGSELYp+ssoLNSpQDWQ.NAplRIhDGAANpIQsADGuRpaVVThulD.SGtLsApLNG.SuPlllt.ppucVauFHpYpltYSALsppsoLhVDGpplsoWuGEsSppN.lpFGNADuplDGRlHlQcIsLpQpGhsLVphDAhYLAQQsP.psppDLEpLGWoK.KoGNTMShYGpAS	....................................................................p...ppp.u.s..Sp.sWp.ssch+llsGuh.p..hAsGop+hlshlSlDpSGsLVsphpG.ou.hlLtotpAt.ppaHcaEL.a.s.h.sp.osohahDGphIp.s...pspsSppN.I.aGNusuphDGhhthpcIthp.QGcs...................................................................	0	2	2	4
+9097	PF09265	Cytokin-bind		Cytokinin dehydrogenase 1, FAD and cytokinin binding	Sammut SJ	anon	pdb_1w1o	Domain	Members of this family adopt an alpha+beta sandwich structure with an antiparallel beta-sheet, in a ferredoxin-like fold. They are predominantly found in plant cytokinin dehydrogenase 1, where they are capable of binding both FAD and cytokinin substrates. The substrate displays a 'plug-into-socket' binding mode that seals the catalytic site and precisely positions the carbon atom undergoing oxidation in close contact with the reactive locus of the flavin [1].	20.50	20.50	20.70	20.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.94	0.70	-5.26	18	278	2012-10-02 00:48:38	2006-08-23 13:02:20	5	5	80	16	137	330	2	242.40	36	52.73	CHANGED	Pp+VRWlRllYoDFssFTcDQEhLIShpss.t.......hDYVEG.lhls.puhhsshpos..............FsPsD.s+luslss..sutVlYCLEsshaYc........ss...s.ssshDQcl-sLhppLsaltGhlFppDVsYh-FLsRV+ppEhpLRupGLW-VPHPWLNLFVP+SpItcFccuVFcuI.Lpssss.GPlLlYPhN+sKWDs+hSslhP.-...E-VFYhVGlLpSu.....suhssl-cLpppNccIlcFC......c..puGIshKQYLPaa..sopp-..W.p+HFG.s+WsRFsc+KscYDP+sILuPGQpIF	..............................................................PthV+WlRhlYssFstFotDQEhLluh.tt.........hDYlEG.lhhs....p..s..ssh......ss..................h.sstp...phsth.t....tuth..lYsL..Ehsh.as..............tt...p..tsshs....pclptlLtpLpah.uhhFtpDlsYh-FLsRV+t.tE.pLRupGhW-.V.P.HP..WLNLFlP.......cSpItcFsptVFpsl.L.pp..s...s...s..........G.PlL.lYPhs+.sKWDsph.Ss...sh.P..-.......--lFYhVuhLpou............sssslcpl.ppNpcIlchC........p..tsslthK.pYLspa....popt-..W.tpHFG....s+WppFhptKtpaDPhtILuPGQtIF.................................................................	0	23	81	113
+9098	PF09266	VirDNA-topo-I_N		Viral DNA topoisomerase I, N-terminal	Sammut SJ	anon	pdb_1vcc	Domain	Members of this family are predominantly found in viral DNA topoisomerase, and assume a beta(2)-alpha-beta-alpha-beta(2) fold, with a left-handed crossover between strands beta2 and beta3 [1].	25.00	25.00	43.80	43.70	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.61	0.72	-4.09	13	69	2009-01-15 18:05:59	2006-08-23 13:10:41	5	2	45	4	0	56	0	57.70	68	18.51	CHANGED	haYpDGKLFpDKphop.Vsp..DNPsYEILK+lKIPsHLoDVlVYEQTaE-AhspLIFVG	.LFYKDGKLFsDssFhNPVSD..DNPAYEVLpHVKIPoHLTDVVVYEQTaEEALTRLIFVG	0	0	0	0
+9099	PF09267	Dict-STAT-coil		Dictyostelium STAT, coiled coil	Sammut SJ	anon	pdb_1uur	Domain	Members of this family are found in Dictyostelium STAT proteins and adopt a structure consisting of four long alpha-helices, folded into a coiled coil. They are responsible for nuclear export of the protein [1].	20.70	20.70	21.40	21.40	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.54	0.71	-3.86	3	15	2009-01-15 18:05:59	2006-08-23 13:26:01	5	3	4	2	15	17	2	109.90	33	13.48	CHANGED	QpILNEIaKLphpQ+ETL-KMhIsQKQlLu+hssshspNscEsL+SLss-QsTLuuQl-oEloALsQlcpshILEPs-LsKLhhLLQDLoIQhKQLcLYHpELQhllsPQcPsP	..........................................p.llsphh+Lh.tQcppL.pMhh.QpplLsc................hspsp.hphhptLpscQsTL+pQI-sEhouLpplhpphIL-Ps-LpKlhhLlp-LpIQh+QLcLhHpELQhllsPppP.........	2	12	15	15
+9100	PF09268	Clathrin-link		Clathrin, heavy-chain linker	Sammut SJ	anon	pdb_1utc	Domain	Members of this family adopt a structure consisting of alpha-alpha superhelix. They are predominantly found in clathrin, where they act as a heavy-chain linker domain [1].	20.60	20.60	20.60	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.46	0.72	-6.38	0.72	-4.87	17	470	2012-10-11 20:01:01	2006-08-23 13:48:23	5	23	355	13	187	307	3	24.00	68	2.26	CHANGED	-psIlPYlpspLpNs-LAl+lAsR	....EENIIPYITNVLQNPDLALRMAVR.	0	59	97	144
+9101	PF09269	DUF1967		Domain of unknown function (DUF1967)	Sammut SJ	anon	pdb_1udx	Domain	Members of this family contain a four-stranded beta sheet and three alpha helices flanked by an additional beta strand. They are predominantly found in the bacterial GTP-binding protein Obg, and are still functionally uncharacterised [1].	20.70	20.70	21.20	22.10	20.50	18.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.02	0.72	-4.31	110	2054	2009-09-11 09:14:44	2006-08-23 14:07:22	6	7	2030	1	404	1340	191	69.80	42	15.64	CHANGED	Fpl...p+..csss..........hahVpGpclERhlphTshs.scEulthhtctLcphGVc-tLcctGsc.sGDtVpI..s....chpF-a	....................FpI..pR..-s..Du.......salloGp+lE+hhphTsFs.pD......EultpFA+pL+phGV--uL+.cpGA+.sGDhV+Is.....sh.EFEF........	0	162	293	361
+9102	PF09270	BTD	Beta-trefoil;	Beta-trefoil DNA-binding domain	Sammut SJ	anon	pdb_1ttu	Domain	Members of this family of DNA binding domains adopt a beta-trefoil fold, that is, a capped beta-barrel with internal pseudo threefold symmetry. In the DNA-binding protein LAG-1, it also is the site of mutually exclusive interactions with NotchIC (and the viral protein EBNA2) and co-repressors (SMRT/N-Cor and CIR) [1].	25.00	25.00	32.90	26.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.13	0.71	-4.48	7	243	2009-01-15 18:05:59	2006-08-23 14:47:35	5	7	119	7	151	235	0	146.30	56	27.06	CHANGED	lCIspsopVuLFNRlRuQTVsT+aL..........................slEss......shtuustpWssFtlphh..........ss+sp.cchshp-G.hlpYGslVhLVsp.TGlt.PPlhl+KV-ptpulLss...s-PVSpLpKh....AFphp-....us+hYLslspc+l.p.....................hpss..sp..s+..lssGupW	..............LCIuSGoKVALFNRLRSQTVSTRYL..........................cVEsG............s..FpASopQWuAFhIH...Ll-........................Ds..c..u..puc-.......Fs.l.R-G...YI.+YGpsVcLVCoVTGhuLPhLIIRKV......D.KQpAlLD...........u....................D...............-PVSQLHKC....AF.hhD............scphYLCLS.pE+IlQ.....................FQ..AoPCP.KEsN+thlNDuusW.....................................................	0	61	71	112
+9103	PF09271	LAG1-DNAbind		LAG1, DNA binding	Sammut SJ	anon	pdb_1ttu	Domain	Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding [1].  This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.	25.00	25.00	27.30	25.20	24.40	23.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.98	0.71	-3.70	12	251	2009-01-15 18:05:59	2006-08-23 15:01:53	6	6	119	7	155	234	0	132.00	55	24.73	CHANGED	slhlhHu+VAQKSYGsEKRFhCPPPhlYLhGsuW......pht....tp.hp...................tsh..sppu.....splsuahsluusst....phpphsh-st................hssA..KoLaISD.sD.KRKphpLtlphhh...........ssu....pcl......GhF.SphIKVISKPSKK+pohKss-	.................................................................TVhILHAKVAQKSYGNEKR.....F.FCPPP.CVYLhGsGW................+hK........ppph.pp......................................................pup...u-pt.............sp.CualGIGsusp.....-hQpLsh-s.t......................................................................passA..KTLYISD..oD.KRKHFhLsl+hah.....................................usu......c-l....................GsFhS+pIKVISKPSKKKQSLKNsD.....................................................................	0	64	75	116
+9104	PF09272	Hepsin-SRCR		Hepsin, SRCR	Sammut SJ	anon	pdb_1p57	Domain	Members of this family form an extracellular domain of the serine protease hepsin. They are formed primarily by three elements of regular secondary structure: a 12-residue alpha helix, a twisted five-stranded antiparallel beta sheet, and a second, two-stranded, antiparallel sheet. The two beta-sheets lie at roughly right angles to each other, with the helix nestled between the two, adopting an SRCR fold. The exact function of this domain has not been identified, though it probably may serve to orient the protease domain or place it in the vicinity of its substrate [1].	26.70	26.70	26.80	27.10	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.33	0.72	-3.83	2	55	2012-10-03 20:35:02	2006-08-23 15:58:54	5	4	32	6	24	43	0	105.50	65	25.71	CHANGED	sLapVQlSsuDpRLhVhDpTphpW+hlCSSpsNthlAslsCEEMGFlRAlsaS.hss.puG..GspsFFCVcEutLshup+lhssl.sCcCs+GphLpshCQDCGRRhLP	...............LYsVQVSsuDuRLhVFDcTEGTWRL.LCSS.RSNuRVAGLSCEEMGFL......RA.L.sHSE..LDVRTAG.ANGTSGFFCVDEGcLPaup..RLL-VIS.VCD.CPRGRFLsslCQDCGRR.KLP.................	0	1	3	9
+9105	PF09273	Rubis-subs-bind		Rubisco LSMT substrate-binding	Sammut SJ	anon	pdb_1p0y	Domain	Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.43	0.71	-4.22	43	613	2009-01-15 18:05:59	2006-08-23 16:27:20	6	17	220	26	433	611	10	124.40	18	24.97	CHANGED	lspsD.hhtp....KtplLcptGhsss..t.hslthsss.........hstcLLsaLRllshsspchtthtsstpstsh................slStpN............EtpshphltshspthLspYsTTlc-.Dct..hlcp...sshptp..................tphAlplRhsEKcIL	.............................................................................+.phlt.....p..s.....h.tp.......h.lthst....................s.pLlsh.LR.lhth.s.t...p...ch..p.ph.t.th.tts.......................................................h..u.ss......................................Etps.hp.h.L.tstsp.hhL.ppa.sT....o.l..cc.....Dpp.....lLpp....ts....ttp.............................................................tphAlplRhtEKplL....................................................................................	0	156	269	351
+9106	PF09274	ParG		ParG	Sammut SJ	anon	pdb_1p94	Domain	Members of this family of plasmid partition proteins adopt a ribbon-helix-helix fold, with a core of four alpha-helices. They are an essential component of the DNA partition complex of the multidrug resistance plasmid TP228 [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.52	0.72	-4.05	3	92	2012-10-02 18:44:02	2006-08-23 16:30:01	5	1	84	2	16	60	5	66.00	30	86.74	CHANGED	MALEKsHTSsKKMTFGEHRDLEKVVsSPlPSGKpKRVNVNFDEEKHTRFKAACAKpGTSITDVINQLVDNWLKENE	........................................................................stt.hKRVssNh..sE-hHpRhKhtCscpGpSIsDllspLl.cpaLpp...........	0	6	10	14
+9107	PF09275	Pertus-S4-tox		Pertussis toxin S4 subunit	Sammut SJ	anon	pdb_1prt	Domain	Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology [1].	25.00	25.00	254.40	254.10	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.55	0.72	-3.96	2	5	2009-01-15 18:05:59	2006-08-23 16:43:19	5	1	5	12	1	5	0	110.00	99	72.37	CHANGED	DVPYVLVKTNMVVTSVAMKPYEVsPTRMLVCGIAAKLGAAASSPDAHVPFCFGKDLKRsGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELIRMVECSGKQDCP	DVPYVLVKTNMVVTSVAMKPYEVTPTRMLVCGIAAKLGAAASSPDAHVPFCFGKDLKRPGSSPMEVMLRAVFMQQRPLRMFLGPKQLTFEGKPALELIRMVECSGKQDCP	0	1	1	1
+9108	PF09276	Pertus-S5-tox		Pertussis toxin S5 subunit 	Sammut SJ	anon	pdb_1prt	Domain	Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology [1].	25.00	25.00	217.50	217.30	20.60	17.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.30	0.72	-4.02	2	5	2009-01-15 18:05:59	2006-08-23 16:44:09	5	1	5	6	1	8	0	97.00	96	75.90	CHANGED	PTHLYKNFTVQELsLKLKsKNQEhCLTAFMsGRSLVRACLSDAt+p+sTWFDTMLGFAISAYALKSRIALTVEDSPYPGTPGDLLELQICPLNGYCE	PTHLYKNFTVQELALKLKGKNQEFCLTAFMSGRSLVRACLSDAGHEHDTWFDTMLGFAISAYALKSRIALTVEDSPYPGTPGDLLELQICPLNGYCE	0	1	1	1
+9109	PF09277	Erythro-docking		Erythronolide synthase, docking	Sammut SJ	anon	pdb_1pzq	Domain	Members of this family of docking domains are found in prokaryotic erythronolide synthase. They adopt a structure consisting of a bundle of four alpha-helices, and mediate homodimerisation of the protein, stabilising the resulting complex [1].	24.60	24.60	25.00	25.00	23.60	24.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.86	0.72	-4.28	2	8	2009-01-15 18:05:59	2006-08-23 16:59:38	6	5	7	2	3	10	0	54.80	50	2.20	CHANGED	uA.PsVslGsRLD-LE+AL-ALsstpGHsDVGtRLEuLLRRWpSRRsstspsssIS-D	............slhscLDcLE+ALcALPsEDG.Hs-VusRLEuLLRRWpsRRAsAsus...............	0	1	2	3
+9110	PF09278	MerR-DNA-bind		MerR, DNA binding	Sammut SJ	anon	pdb_1q08	Domain	Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-9.01	0.72	-3.57	304	2740	2012-10-04 14:01:12	2006-08-24 08:59:03	6	15	1578	18	772	6957	665	64.40	30	43.61	CHANGED	lpRLphIppu+plGFoLsEI+plL....sl.......pp..t.spssschp..plhpp+ltclcp+lpcLpphcpp.Lpph	.............hcplthI+pAp.c.lG.hoLscI.tclL.....sL....................ps.....c..sts.s.p-..hc..........plu..p.p+....h....p....-.l.-...c....+I....p....p.Lp.thcsp.Lpth..........................................................	0	215	470	645
+9111	PF09279	EF-hand_like	efhand_like;	Phosphoinositide-specific phospholipase C, efhand-like	Sammut SJ	anon	pdb_1qas	Domain	Members of this family are predominantly found in phosphoinositide-specific phospholipase C. They adopt a structure consisting of a core of four alpha helices, in an EF like fold, and are required for functioning of the enzyme [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.76	0.72	-3.96	63	1479	2012-10-02 16:17:27	2006-08-24 09:12:10	6	79	244	26	795	1356	2	83.20	25	8.27	CHANGED	ElpplFppa.us.p...pphlospcLhcFLpccQ+csch........s.pcpstplIpc.....aEssp.....pspcc.......thlol-GFhpYLhSs-sslhssp+hcla	....................................-l..lh.ph...us...p.......pthlo.hppLhpF...Lp.pcQ..p.-sph.........................................s...ppstpl.Ipc.............a..Essp.......................ptppc...............................shloh-.GFhpYL.h.S.p.-.sslhsspp.pl..................................	1	179	275	510
+9112	PF09280	XPC-binding		XPC-binding domain	Sammut SJ	anon	pdb_1pve	Domain	Members of this family adopt a structure consisting of four alpha helices, arranged in an array. They bind specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair [1].	22.80	22.80	22.80	24.50	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.94	0.72	-4.51	36	513	2009-01-15 18:05:59	2006-08-24 09:22:59	6	13	297	12	316	512	7	58.10	44	15.62	CHANGED	Ls.hLpspPQFpplRphlQpNPplLpslLQplupsNPpLhph...Ippsp-tFlphLsp.ssss	.............L-FLRspPQFQplRpllQpNPp....lLtslLQQlGppNPpLhph.......IpppQ-pFlphLNE.ss..s............	0	95	163	247
+9113	PF09281	Taq-exonuc		Taq polymerase, exonuclease	Sammut SJ	anon	pdb_1qtm	Domain	Members of this family are found in prokaryotic Taq DNA polymerase, where they assume a ribonuclease H-like motif. The domain confers 5'-3' exonuclease activity to the polymerase [1].	25.00	25.00	76.00	74.10	21.90	21.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.89	0.71	-4.03	4	36	2009-01-15 18:05:59	2006-08-24 09:36:09	5	4	33	37	13	49	0	130.30	60	15.85	CHANGED	stPcE.A.hssPEGshhG.lLspscP....hhAphtA.tAsp-uch+RAs......Plsu.A-h...+EVpuhhAKsLAshhShcGssl-PGDDPLLlAYLLDPANTN..sVA+RY.ssEWsEDAApRAhlotRLhpsL.P+L	...............shEEAPWP.PPEGAFVGFlLSR.sEP....MWA-LhALAAAp-GRVH.RAss......PhtuLcDL...+ElRGlLAKDLAVLALREGlsLsPGDDPhLLAYLLDPSNTsPEGVARRY.GGEWTEDAucRALLoERLapsLh.RL......	0	3	8	13
+9114	PF09282	Mago-bind		Mago binding	Sammut SJ	anon	pdb_1rk8	Domain	Members of this family adopt a structure consisting of a small globular all-beta-domain, with a three-stranded beta-sheet and a contiguous beta-hairpin. They bind to Mago alpha-helices via extensive electrostatic interactions and at a beta2-beta3 loop via hydrophobic interactions [1].	20.60	20.60	20.60	25.60	20.20	18.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-6.79	0.72	-4.37	11	235	2009-01-15 18:05:59	2006-08-24 09:52:20	5	3	201	1	178	238	0	26.60	56	12.55	CHANGED	G-+hIPsopRsDGohRKsl+lRsGYhP	....Gp+aIsuopRPDGThRKthRV+sGYhP..	1	60	94	146
+9116	PF09284	RhgB_N		Rhamnogalacturonase B, N-terminal	Sammut SJ	anon	pdb_1nkg	Domain	Members of this family are found in prokaryotic Rhamnogalacturonase B, and adopt a structure consisting of a beta supersandwich, with eighteen strands in two beta-sheets. The exact function of the domain is unknown, but a putative role includes carbohydrate-binding [1].	27.00	27.00	28.30	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.51	0.70	-5.02	6	102	2009-09-11 00:34:51	2006-08-24 11:09:34	5	8	71	5	74	110	2	228.70	42	45.15	CHANGED	FGhTsoGssaslDuGus..LlFpVsKoosDlsSlpYRGsEhQ.YsuKuSHIuSGLGSATVosppluu....aIKVTssoSoL..THYals+sG-ssIYMAT.hsAEsslGELRFlARLpsshLPs..ptPaupVuTTtGsou.IEGuDVFll.sGpTRSKFYSScRFIDDchH......slSGuu..spVCMlhs..saEsSSGGPFFRDIsopssu-sssLYaYMNSGHVQTEuaRhGLHGPYulsFocuGsPssu....plDTSFFs.oLGIsG	........................FGhTpousphllDsGus..LsFsVs.psssDIsSlpYpusELQ.hpup.sSHIsSGLGo.u.o..V.shp..phss........hIhVosps.......u....s....L..spYhls+pGcssIYMAT.hsscsslG..ELRFlARLssshLPs....p.shussuss......s.ps.IEGsDVFhl.sGpTpSK....FYSup......RhIDDphH......sVsGsu...htVhhlhs...shEpSSGGPFFRDIssppssstppLY.Y..M.SsHsQT.....EsaRhG.LHGPYuhhFocuusPsss......l.DhuFhs.sLslpG..................................	0	30	45	66
+9117	PF09285	Elong-fact-P_C		Elongation factor P, C-terminal	Sammut SJ	anon	pdb_1ueb	Domain	Members of this family of nucleic acid binding domains are predominantly found in elongation factor P, where they adopt an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology [1].	25.00	25.00	25.20	27.80	20.20	23.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.56	0.72	-4.62	108	5622	2009-01-15 18:05:59	2006-08-24 11:26:27	6	9	4549	10	1133	2891	2007	55.20	50	29.52	CHANGED	VpLpVscT-PulKGsT.uoust.KPApLE.TG.hplpVPhFIppG-pIplcTcs.GpYlsR	.............V-Lcls-T-PGl.KG...DT...u...........o.u.us.KPATLc..T.....G.....hs.....lpVPhFlptG-hlclcTcs.GpYluR............	0	377	737	951
+9118	PF09286	Pro-kuma_activ		Pro-kumamolisin, activation domain 	Sammut SJ	anon	pdb_1t1e	Domain	Members of this family are found in various subtilase propeptides, and adopt a ferredoxin-like fold, with an alpha+beta sandwich. Cleavage of the domain results in activation of the peptide [1].	20.90	20.90	20.90	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.64	0.71	-4.15	124	1063	2009-01-15 18:05:59	2006-08-24 11:45:25	6	31	332	4	629	1085	28	137.50	21	20.46	CHANGED	sshtphstssssph...l.p..lplsL.ppps..h..splcphlhpl..ssPssspY......................spa..LotpphtphauPsppslstVtsaLpstG.lsstp....................tsstphlshsuolupsc...............phh.ps..phthYp..................ssst.........hhhp..ssp..plPppls....................................shlshl....hs....hsph	..............................................t.......t.t.h.sssp.....l.p...lplsL....p.ps....h...sp..Lpphl...h.pl..ss.Psu.s.pY......................sc.a.....Lo..pphtphau.......Ps.sp......slstVtsaL.p..p...p....G...lsstp.............................ssspshlph.p.uolsps-...............phh.ss.....phptap....................tstp................hhhp.ss.p..hplPtplt....................................shlshl....hshp...................................................................	0	204	379	512
+9119	PF09287	CEP1-DNA_bind		CEP-1, DNA binding	Sammut SJ	anon	pdb_1t4w	Domain	Members of this family of DNA-binding domains are found the transcription factor CEP-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology [1].	17.80	17.80	18.30	17.80	17.60	17.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.42	0.71	-4.88	2	7	2012-10-03 00:25:27	2006-08-24 11:57:19	5	1	7	1	7	9	1	171.90	28	36.20	CHANGED	EcWhph-VhKp+suKsSDhtFthsspcthYLWsKMtC.lPh.VKWplsppH..ppL.L+lRhVpY.tp-NlE.uIRsP.SslhKC+sHp.pEp+hPh-SFFYlhpStccao..hsucKspsFshhhhPGssQs.FDlIFhCQcpCLDLs-RRKpMCLAVFL-DENGNElLHshIKQlhIVuYPRRDWKNFCE+csshp	.............h...hphpV.pt+stK.Ssh.....st.thhLWo+hts.lPh.lpWplspth...pppL.L+lRlVpY.tppslp.uI+ss.sslhKCpsHp.cEp+.hPh-uFFYlhsSspcas.....hs...p+.uppasshl.s..Gthp..ltFDlIFhCQcpChtlt-+RKphCLssFL-DE.tp.l.athlcplhlhuYPpRDhpNFp.+..............	3	2	3	7
+9120	PF09288	UBA_3		Fungal ubiquitin-associated domain 	Sammut SJ	anon	pdb_1tte	Domain	Members of this family of ubiquitin binding domains adopt a structure consisting of a three alpha-helix bundle. They are predominantly found in fungal ubiquitin-protein ligases [1].	20.40	20.40	20.40	20.50	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.58	0.72	-4.37	6	131	2012-10-01 23:03:33	2006-08-24 12:52:50	5	3	125	1	95	122	2	50.80	36	19.96	CHANGED	DEupLYGID+-lV-pFsuQGFE+sKllEsL+RLslKohs.sDNpTsN+IlEELLK	.................thh.Ghs+-LVDcFpsMGF-h-+VV-sh+hlGIcphss.s..................................	0	21	50	80
+9121	PF09289	FOLN		Follistatin/Osteonectin-like EGF domain	Sammut SJ, Bateman A	anon	pdb_1nub	Domain	Members of this family are predominantly found in osteonectin and follistatin and adopt an EGF-like fold [1,2].	21.10	21.10	21.50	21.20	20.20	21.00	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.79	0.72	-6.84	0.72	-4.09	14	363	2012-10-03 09:47:55	2006-08-24 13:32:02	5	12	89	21	133	310	0	21.90	49	6.20	CHANGED	CtNacCK+GKsCchscps+PhC	..CtNhpCttGKhCchsc.pscPpC	0	9	22	54
+9122	PF09290	AcetDehyd-dimer		Prokaryotic acetaldehyde dehydrogenase, dimerisation	Sammut SJ	anon	pdb_1nvm	Domain	Members of this family are found in prokaryotic acetaldehyde dehydrogenase (acylating), and adopt a structure consisting of an alpha-beta-alpha-beta(3) core. They mediate dimerisation of the protein [1].	25.70	25.70	26.10	32.80	19.20	25.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.82	0.71	-4.27	62	778	2009-01-15 18:05:59	2006-08-24 13:46:32	6	4	619	4	192	558	124	146.10	64	47.83	CHANGED	CGGQATIPlVtAlSRVs.sVcYAEIVASIAS+SAGPGTRANIDEFTcTTucAlEpVGGAp+GKAIIlLNPAEPPllMRDTVasLsc..ssD...pssIpsSlppMltcVppYVPGYRLKppspF-th....................+VolFL..EVEGAucYLP	.....CGGQATIPhVAAVSRVs.....pVpYAEIVASIAS+SAGPGTRANIDEFTcTTu+AIEsVGGAs+GKAIIlLNPAEPPLhMRDTVasLs-...-Ac.......p-sIpASIp-MsctVQsYVPGYRLKpcsQ.F.-shs.st............................hsth+suVaLEVEGAucYLP....................	0	45	122	164
+9123	PF09291	DUF1968		Domain of unknown function (DUF1968)	Sammut SJ	anon	pdb_1oga	Domain	Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.	25.00	25.00	36.80	36.30	22.90	17.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.80	0.72	-4.17	4	101	2009-01-15 18:05:59	2006-08-24 13:54:43	5	2	23	79	18	841	0	84.50	59	39.18	CHANGED	PAVYQL+DPpSsDpolCLFTDFDS.QsNVsp...StsSssalTspTVLDM+uMDSKSNGAlAWSNposFuCpssFp..NuohP.uDs..Ps	PAVYQLR..sspSSDpSVCLFTDFDS.QsNVSp...ScsS-ValTspTVLDM+uMDSKSNGAVAWSNpSDFuCpsAFp....NuslP.usoh.......................	0	1	1	2
+9124	PF09292	Neil1-DNA_bind		Endonuclease VIII-like 1, DNA bind	Sammut SJ	anon	pdb_1tdh	Domain	Members of this family are predominantly found in Endonuclease VIII-like 1 and adopt a glucocorticoid receptor-like fold. They allow for DNA binding [1].	25.00	25.00	27.00	25.80	18.50	17.30	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.05	0.72	-4.15	6	57	2009-01-15 18:05:59	2006-08-24 14:08:40	5	4	41	1	31	51	0	38.60	70	10.96	CHANGED	sYSsFcsWLpCYhVsGMsSLRD+NGRTIWFpGDPGPLAP	.DauAF+AWLpCYssPGMsSLRD+pGRTIWFQGDPGPLAP....	0	6	8	15
+9125	PF09293	RNaseH_C		T4 RNase H, C terminal	Sammut SJ	anon	pdb_1tfr	Domain	Members of this family are found in T4 RNaseH ribonuclease, and adopt a SAM domain-like fold, consisting of a bundle of four/five helices. These residues may have a role in providing a docking site for other proteins or enzymes in the replication fork [1].	25.00	25.00	25.30	27.10	22.80	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.42	0.71	-4.21	8	45	2012-10-01 19:52:02	2006-08-24 14:24:43	5	2	42	6	0	45	191	115.00	40	38.84	CHANGED	GSPcpDLhsKlIKGDtKDGVAuIKsRSDallT+VEGERAPsspsKhLEsl....h-sEDP+sLLTsEEa.pRacENpcLlDFDaIPDcIuspIlppYNo.KssPRuKlYsYFVKsuLsKLls+ls-F	................GosthDhhsKllKGD+KDsVAulKsRuDahho.+VEGERsPshpsphlEtl....h-p-pscsLlTc-p..a.pRacENphLIDFDaIPDsItspIlptYNshphs.s+uKlYsYFVKsuLsKLhspls-F.................	0	0	0	0
+9126	PF09294	Interfer-bind		Interferon-alpha/beta receptor, fibronectin type III	Sammut SJ	anon	pdb_1n6u	Domain	Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.62	0.72	-4.00	96	681	2012-10-03 16:25:20	2006-08-24 14:40:10	5	13	59	57	291	719	22	99.50	21	28.34	CHANGED	TplGPPp.lpl...pstssslplslpsP.......pspthohpslas.phtYplhhacsu..ss....cppthpsspsh.hlpsLpPtosYClpVpu.......ths+pu.hSphpChpTs	..............................................luPPt.lpl...ps.ssslplplpsP...............tttths.......h.....p.......phas.......t....h.....p.Y...plh.....hhcss..ss.............ppp.t..h......p.......s..p..t..s...h...h...lpsLp.....P.....t.o..s..YClpVps.......t.s+pu.h....Sp.pChp..........................................	0	14	34	115
+9127	PF09295	ChAPs		ChAPs (Chs5p-Arf1p-binding proteins)	Mistry J, Wood V	anon	Pfam-B_11349 (release 19.0)	Family	ChAPs (Chs5p-Arf1p-binding proteins) are required for the export of specialised cargo from the Golgi.\	 They physically interact with Chs3, Chs5 and the small GTPase Arf1, and they form also interactions with each other [1].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.29	0.70	-5.70	14	327	2012-10-11 20:01:01	2006-08-24 15:27:08	5	42	208	0	196	576	86	276.20	23	43.34	CHANGED	psclGoaaYssGlDsSssASlAsaLpsLs.pl.pcsQhWFGcppsaKlsphoYCsaNAFo+sDhRVpV+IPGuV-oahlDpcG-+......cpt.................s-plWtETalSullRulhhu-D.......................ssssphpplstsRphNPhoss-h-cc.......FlcshEpLFhcGhpLGussclts..PThlsNaLVcullchh+hTppacpulsll-+Lpppp.PEVssLlA+lhlhtDcElcAV+lhpcuL........pps.pD.......ssLLslQucFLlsKc+s...........chALpsAppAVpuuPSEFtTWshLsclYlcLpDhENALLoLNSCPM...oapEK.hh+hssPhc.......lHLPlPh-ssL-Elsshsssc.....ppcpsDPsLlpLsAusL+uTFtpAYpLLTEIVpphGW-pLLKhRSpVFVMEEEYR	.........................................................................................................................................................t..........................................................................................hs.shs..htp.-hph....h.......t......p.................h...t.tt..................................................hW.Eh.hsthlR.h....p................................h....t..........................hh......h..h..h.......................u...............t...............................................s..h..........p....N.hL..ht..sh......h...hh...t....s.....p...h..t.....sh....phhc...p.........l..h..p...p......p....s....p.....s..............h....l....sp...l...h...h.............t...p..p...E...h......pu..lph...hpp.hl................pp..........s.................t.hL...hQu...pahhpp.tc.......................chAlph..uppusphsPspapsWhh.LsphYh.thpph-pA..L....h....s...l.N.u....hPh...........pp.p..........................................................................................................................................................................................................................................	2	63	120	174
+9128	PF09296	NUDIX-like		NADH pyrophosphatase-like rudimentary NUDIX domain	Sammut SJ, Bateman A	anon	pdb_1vk6	Domain	The N-terminal domain in NADH pyrophosphatase, which has a rudiment Nudix fold according to SCOP.	21.20	21.20	21.20	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.44	0.72	-3.65	75	1383	2012-10-02 00:00:35	2006-08-24 15:37:11	6	14	1293	3	430	990	338	99.50	22	32.64	CHANGED	puhhhlhpssplllps.......................................ththsththtth...........................shshtpslhLG...hhps........................pshaulshsttss.........................shphhsLRphh......htls.spphslhupAtpllpW	...........................................................................................t.shhll.pc.pplhlsp.......................................................s.tls.h.s.pstph.............................................shssp.pslh..lG.........phpu......................................psla.slphsttts.........................................................h.h..ssl.Rplh...................pls..ss.htlhupAhpLhpW.............................	0	106	236	334
+9129	PF09297	zf-NADH-PPase		NADH pyrophosphatase zinc ribbon domain	Sammut SJ, Bateman A	anon	pdb_1vk6	Domain	This domain is found in between two duplicated NUDIX domains. It has a zinc ribbon structure.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.69	0.72	-4.43	63	1999	2012-10-03 10:42:43	2006-08-24 16:14:14	6	20	1879	3	487	1363	306	31.80	34	10.88	CHANGED	psapFCupCGstsphtps.thuphC..ssCstpta	.....sa+FCutCGptht.sps..t..huhhC....spCtpchY........	0	120	265	382
+9130	PF09298	FAA_hydrolase_N	DUF1969;	Fumarylacetoacetase N-terminal	Sammut SJ, Eberhardt R	anon	pdb_1hyo	Domain	The N-terminal domain of fumarylacetoacetate hydrolase is functionally uncharacterised, and adopts a structure consisting of an SH3-like barrel [1].	25.00	25.00	25.00	26.60	22.30	24.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.32	0.72	-4.05	94	764	2009-09-11 16:58:44	2006-08-25 09:49:03	6	9	631	10	393	776	109	99.60	35	23.95	CHANGED	QNLPaGlFo.pss.ss....RsGVAIGDpllDLuul.ttt..................G.lhs......ts.tsshspssLNsFhuLGtssWpslRtpLppLLp.................thpsppshhptsLlstuc.sph+LP	.............................pNLPaGlFS.sss..ss.........RsGVAIGDpllDLuul.ttt...................u.lhs............t..tssFs..psoLNsFhuLG+ss..WptlRtpLppLLs.........................hpsspshtppsLls.sc..sphHLP........................................	0	104	219	322
+9131	PF09299	Mu-transpos_C		Mu transposase, C-terminal	Sammut SJ	anon	pdb_1bco	Domain	Members of this family are found in various prokaryotic integrases and transposases. They adopt a beta-barrel structure with Greek-key topology [1].	20.50	20.50	20.50	20.50	20.30	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.03	0.72	-4.09	36	1172	2009-01-15 18:05:59	2006-08-25 10:46:00	6	26	862	3	233	975	33	64.70	26	11.47	CHANGED	Lclhhh....stptRpVp+........sG.lphh...sh+Yhsst.Ltua..sGcp...VhlRYDPpDl.splhVapp..sG......alspA	...............................hhh.....ttpRp.lp+........sG..lphp.............sh.p.Y......h.s......st....L.t.sh..........hucp...........VhlRaDPp..Dh..splhVhp...st.....hh...............................	0	68	146	204
+9132	PF09300	Tecti-min-caps		Tectiviridae, minor capsid	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	Members of this family form the minor capsid protein of various Tectiviridae [1].	25.00	25.00	197.80	197.70	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.96	0.72	-4.20	3	7	2009-01-15 18:05:59	2006-08-25 14:36:31	5	1	6	1	0	4	0	84.00	98	100.00	CHANGED	MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRAVAEQTYYAIGTGIQMGQTFNQPLINTQEG	MALINPQFPYAGPVPIPGPAPTETMPLLNYRVEGRIAGIQQARQFMPFLQGPHRtVAEQTYaAIGTGIQMGQTFNQPLINTQEG	0	0	0	0
+9133	PF09301	DUF1970		Domain of unknown function (DUF1970)	Mistry J, Sammut SJ	anon	pdb_1w8x	Domain	Members of this family consist of various uncharacterised viral hypothetical proteins.	22.50	22.50	24.70	266.90	20.40	17.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.60	0.71	-4.05	3	7	2009-01-15 18:05:59	2006-08-25 14:42:11	5	1	6	1	0	5	0	117.00	96	100.00	CHANGED	MDKKKLLYWVGGGLVLILIWLWFRNRPAAQVASNWEGPPYMTYNQPQAGSVTLPVAGYTSPSLTLPNRNRSCGCNPAVSAAMAQGADLASKLTDSITSQLNNYAESLNDYLASQAGV	MDKKKLLYWVGGGLVLILIWLWFRNRPAAQVASNWEGPPYMTYNQPQAGSVTLPVAGYTSPSLTLPNRNRSCGCNPAVSAAMAQGADLASKLT-SIoSQLNNYAESLNDYLASQAGV	0	0	0	0
+9134	PF09302	XLF		XLF (XRCC4-like factor)	Mistry J, Wood V, Hentges P, Doherty A	anon	manual	Family	XLF (also called Cernunnos) interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining.  It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated downregulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining [1].  This family contains Nej1 (non-homologous end-joining factor) [2], and Lif1 [3].	21.70	21.70	22.80	21.70	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.64	0.71	-4.48	30	240	2009-09-11 09:52:26	2006-08-25 15:05:44	6	5	179	28	128	239	0	164.00	22	41.85	CHANGED	tsWphlplsp..s.........hlhpsphs..tsoas....lhloD........Lps..lWsEclspsslhp+upppstslcs...sspphphhLpclhpsh.......sspcssphsLppt.t.....tssLhlphphclsssh.shpWsh+lpppsss....slhppLshPLlphptshpppt..............................ppLtshLpcKDt...................................slspLh-phps	..................................Wthl.lst.ps.........hlhphhhs..ppu....t....lhlo-........Ltp..lWpEplspss....l.pcspp.spplss...s.sph.hhhLpplhpsh........sspcssphslsttt....................sssLh.lp..hpspLs..sh...shp.Wshclppssss....tlhp...cLhhPLhphttthppph..............................ppLtslLppKDt...................................tlpch.-pht.t............................................................	0	24	53	96
+9135	PF09303	KcnmB2_inactiv		KCNMB2, ball and chain domain	Mistry J, Sammut SJ	anon	pdb_1jo6	Domain	Members of this family are found in the cytoplasmic N-terminus of KCNMB2, the beta-2 subunit of large conductance calcium and voltage-activated potassium channels. They are responsible for the fast inactivation of these channels [1].	25.00	25.00	25.30	25.00	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.13	0.72	-4.18	7	63	2009-01-15 18:05:59	2006-08-29 09:22:20	5	2	35	1	25	55	0	29.60	80	15.20	CHANGED	MFIWTSGRTSSSYRpDEKRNIYQKIRDHDLLD	........MFIWTSGR.TSSSYRHDEKRNIYQKIRDHDLLD.....	0	1	3	9
+9136	PF09304	Cortex-I_coil		Cortexillin I, coiled coil	Mistry J, Sammut SJ	anon	pdb_1d7m	Domain	Members of this family are predominantly found in the actin-bundling protein Cortexillin I from Dictyostelium discoideum. They adopt a structure consisting of an 18-heptad-repeat alpha-helical coiled-coil, and are a prerequisite for the assembly of Cortexillin I [1].	23.90	23.90	24.00	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.53	0.72	-4.00	4	18	2009-01-15 18:05:59	2006-08-29 09:39:01	5	6	11	2	12	18	0	102.60	35	23.56	CHANGED	KEEKtcLEAS+s-hAN+LAuLEpSLEuEKsSp-pL....hKQKDp...LcuhLtoLcupsApRppRlpELpAKl-EhL+NLEhEKhA+hELEuRLuKsEKDKAILELKLAEAhD	..........+EE+ttL-uSpsplts+LAuLppSLEspKtSp-cL.......h+QK-p...LcstLppLcspssspspRls-LpA+ls-sl+sL-p.EKhA+.-LcsRLsKscKD+AhLEL+LtEh.s.........	0	9	11	11
+9137	PF09305	TACI-CRD2		TACI, cysteine-rich domain	Mistry J, Sammut SJ	anon	pdb_1xut	Domain	Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF [1].	21.30	21.30	21.40	21.50	19.00	20.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.11	0.72	-4.16	2	66	2009-01-15 18:05:59	2006-08-29 10:41:35	5	3	27	5	27	55	0	39.30	55	22.37	CHANGED	lsCRKEQG+aYDHLLtsClSCsShCsQHPpQCAaFCEp+.R	............sCp+EQGpYYDpLL+sClSCtSICG.Q.HP+.Q.CAhFCctp......	0	2	2	6
+9138	PF09306	Phage-scaffold		Bacteriophage, scaffolding protein	Mistry J, Sammut SJ	anon	pdb_1gp8	Domain	Members of this family of scaffolding proteins are produced by various bacteriophages [1].	25.00	25.00	25.30	25.80	24.00	24.90	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.88	0.70	-5.27	2	104	2009-01-15 18:05:59	2006-08-29 10:52:09	5	1	99	2	5	48	0	273.20	52	92.96	CHANGED	M-.TT-IQuoE-LTLoGsHAAASADuLVVDNANDNAGQEEGFEIVLK.DE.tPKQDPApNAEFARRRIERKRQRELEQQMEAVKRGELPEpLRVNP-LP.QPD.NsYLSE-uLAKYDYDpSRALAAFptANoEW.hKA.DARSpAVAEQGRKTQEFTQpSAQYVEAARKHYDAAEKLNIPDYQEKEDAFMQLVPPAVGADIMRLFPEKSAALMYHLGANPEKsRQLLAMDGQSALIELTRLSERLTLKPRuK.lSpAP.sDpPIpGcssAANhsAIcKQM-AAAsKGDVETYRKLKApL.KGIR	..................................................................................................................................................................................EpQhEsh.c.RtpL.EuLts.pPs..pQPpssAh..scssLtphDYDpp....AFppA.T-W.p.Kttcsc....pQt.tpptRpp.QEapQp.tQhVEAhtcHhpt.AtKLsl.DYQEhEshhhp.lPPh.tt.Ih.+hh..sEtSthLhYtLGtN.tphRQllA..h.Ds.pAhh.LsplSc+loLtP+sKps..ss.s...h.tts...................................................................	0	2	2	2
+9139	PF09307	MHC2-interact		CLIP, MHC2 interacting	Mistry J, Sammut SJ	anon	pdb_1muj	Domain	Members of this family are found in class II invariant chain-associated peptide (CLIP), and are required for association with class II major histocompatibility complex (MHC) in the MHC class II processing pathway [1].	21.00	21.00	21.10	23.40	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.53	0.71	-4.30	11	121	2010-01-11 15:07:59	2006-08-29 13:06:26	5	6	60	11	32	96	0	111.30	39	44.98	CHANGED	M--QR.....D..LI.ossppshLPh....sssscuusoRuhtloGlolLssLLLAGQAlTsYaVapQpGcIscLTpTspsLphE.LppKhPtu..ssspM+hsM.shPhLhchhs.sss..tss...hc	.....................--Qp.....D..LI.usp...pp...L.sh........sss.cupsoRushhoGhSlLVsLLlAGQAsTAYFlYQQpGplcKLThTSpsLpLEsLph.......Kh.Ptss.sss+M+Msh....Phlhphhs.t.t...hs..t..............................	0	2	7	15
+9140	PF09308	LuxQ-periplasm		LuxQ, periplasmic	Mistry J, Sammut SJ	anon	pdb_1zhh	Domain	Members of this family constitute the periplasmic sensor domain of the prokaryotic protein LuxQ, and assume a structure consisting of two tandem Per/ARNT/Simple-minded (PAS) folds [1].	25.70	25.70	26.10	35.40	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.50	0.70	-5.03	6	115	2009-01-15 18:05:59	2006-08-29 13:44:49	5	8	113	6	14	78	0	236.20	54	28.02	CHANGED	SspIItQEVpRTpQQTSuLIpNlF-p+LuhLQIHpDSsuKstulhchah-pD.s-pLshFFhSlDQt-PopTP-FRFlospcullWDDGNApFYGlNp.hLcplup+VshSNNWaalpsposhG.tahLlRRoPll-ssTGEVlGahYsuVVLsNNFuLhEpL+stSNS-NlVllssspsLASSLsGs.EsY.slssVLppppssp+hDshllscTPIplpussT.lslLolQsNpsVloL	...............SS+lhuQEspRTshQTSSLIQsLFDFRLAALcIH.QD....SoAKNsSLlsALsoRD.sspLDpFFsSVDplEhSNAPDlRFISoHD.sIlWDDGNApFYGIspp..pLs+Lh++VuhSuNWHlVQTPSphpshHlLhRRoulI-ssTGpVlGYLYVGIVLNsNFALlEsI+sGSNS-NlVLsVcosPLsSTLKGN..EP.Y..o.lc.Vl...........+s.uc-sh+.D.ualVuQThLEVcuVPTaLCVYSIQsNQNVlTL............................................	0	5	6	11
+9141	PF09309	FCP1_C		FCP1, C-terminal	Mistry J, Sammut SJ	anon	pdb_1onv	Domain	The C-terminal domain of FCP-1 is required for interaction with the carboxy terminal domain of RAP74. Interaction relies extensively on van der Waals contacts between hydrophobic residues situated within alpha-helices in both domains [1].	22.70	22.70	24.10	24.40	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.96	0.70	-5.08	4	63	2009-09-11 10:47:49	2006-08-29 15:20:43	5	6	42	2	32	66	0	210.90	56	26.15	CHANGED	ERW-KVEEQLFPL+DDaoKspRsNSPAsFPDppush.TsLFHPsPI+sKs.pPGPEVRlYDssTGKLIRpGsQuStPuP......sSuhss+tEPSSFRuVpPpQ.QhFs..EphssuQDsEQPGPSRRKRQPSMSETMPLYTLCKEDLESMDKEVDDILGEGSD.DSDuEKK+s..p.c-pEptsQspK.psPs.RpEp.................s.thPuSSERSssGuRsPRGHKRKLsEE.........DAtSE....pStESSNEDEtGSSSEADEMAAALEAELNDhM	........................................ERW-KVEEQLFPL+-DasKs.p.RpsSPAsFPDppush.TsLFHPsPlpPKs..pPGPEVRlYDssTGKLIRpGs....psst.ss.........s..s.Lsl+tE...S.SFRsVpPpQ.pQhFs....EphssupD...s.EQPGPSR..RKRQPS...MSETM.PL.YTLCKEDLESMDKEVDDILGEsSD.-S-ucc+cs....p.cpct..t.pspp........s.t.pptp...................t.sssupcs.hss.p..sR.GHKRKhp-p..........-htsp.............pStcsSN--E.GSSSEADEMAtALEAELsDhh................................	0	5	8	16
+9142	PF09310	PD-C2-AF1		POU domain, class 2, associating factor 1	Mistry J, Sammut SJ	anon	pdb_1cqt	Domain	Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres [1].	19.20	19.20	19.40	19.20	18.40	18.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.89	0.70	-5.22	2	69	2009-01-15 18:05:59	2006-08-29 15:42:10	5	5	43	2	30	56	0	197.40	55	86.37	CHANGED	MHhtKS.hSEQtsp.+PYQGVRVK-PVKELL+RKRGNs..ApshssTsVVlPppsLPSYo.hG.ssh.ssstuA.s.sus-.GALCsuWluQPSs.uohQPLspWss.P-YhpHEt..uohP.hTuDMYlQPhCPSYslVGPSSVLThAptPLhTNhsshS.STsul.PQl-V..QpssLsYhPWA.PLSshPtss...........sPQhlPhPlslscPtPQp.EsA.ps.GTLslEKLL.E-E-spp..Yshs.uL.spsl	................sEQt.P.s.P.RPYQGVRVKEPVKELLRRKR.....G.+.s.....ssG..s..sssPT.u.V....V..LP.+pPLso.Yos...s.....Gsssl.-h-s.us.ss...s--us.LCsu.....W.luQPss..AsLQ..PLs..s.Woshs-Yh.c-u.......sosP.houDhYl.QPh.CPSYT.hVGsoShLTYus.PL..lTNhssp..............S..usPs..ssP.lEh.-pQuPLTYhPWsQPL...STLPss..oLQYQssussLPGPQFVpLPISIP......EPs.Q-h-DsRR.shsoLsI-KLLLE-E-sss..Y.hspsLslEG.h...............................................	2	1	3	11
+9143	PF09311	Rab5-bind		Rabaptin-like protein	Mistry J, Sammut SJ	anon	pdb_1tu3	Family	Members of this family are predominantly found in Rabaptin and allow for binding to the GTPase Rab5. This interaction is necessary and sufficient for Rab5-dependent recruitment of Rabaptin5 to early endosomal membranes [1].	26.00	26.00	26.00	26.00	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.12	0.71	-4.39	20	544	2012-10-11 20:01:01	2006-08-30 09:24:06	6	90	98	14	254	485	0	165.40	42	29.53	CHANGED	ELuhucuQshhslpppLstlpsp+p+lcspl+RLspENpaLRsEhutoppch..ptpEppstpL.-chccLpahsphp+.Dthpppst....cpchcschssLcp.......hhss.E-phtsph..................p.tsptsstpssthEhsucLRoL+sLllQhssQs+hE........htlshsKpALEDLppsstccpscl	........................................ELuhu-uQlhhuLss+.Lssl-uE+Q+L+s.......QVRR.LsQ.......ENpWLR-E....L..u...s..TQp+L........QpSEppVAQLEE....EpcHLcFh..spl++hD.tsts..s........t..............-.c.....c...t....c.s.p.p.-sLc-..................Lhss-E--.stth...................................................t.tsttustp.puuhElPARL.RTL+NLVIQYuuQ....GRYE...........................VAVPhCKQ..ALEDLp+osG+cHscl...................................................................................	0	51	71	148
+9144	PF09312	SurA_N		SurA N-terminal domain	Sammut SJ, Bateman A	anon	pdb_1m5y	Domain	This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	29.50	29.50	29.50	29.50	29.40	29.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.25	0.71	-4.24	19	1802	2012-10-02 13:36:56	2006-08-30 10:53:39	6	12	1787	8	392	1588	590	113.80	32	28.46	CHANGED	lD+lVAVVN-sVlLpS-L-ptlcpVcpphtppsspLPPcsVLccQVLERLIl-plQlQhAccsGlRlsDspLspAlusIAppNshol-QhppuLup-GloYspaREQIRcEhlluclR	..............................................lDplsAl..VNssllhpo-l....cth....h....p......p....l..ph...p...h.....t....p........t........t.....t.....p...l........P....s......p......s.....t....L.....+....c.......Q..l.......L....-+LIh-pl..lQ......hu.p+.hG.l..c..l..s....DppLD.p...AI....s....s...I.......A....p.......p......N....s...h...T....l......-..Q..h.+..spL....s.t.c.G.l..sa.s....pa....Rpp....lRc....-hhhsclp.........................................	0	109	231	319
+9145	PF09313	DUF1971		Domain of unknown function (DUF1971)	Sammut SJ	anon	Pfam-B_3000 (release 20.0)	Domain	Members of this family of functionally uncharacterised domains are predominantly found in bacterial Tellurite resistance protein.	23.10	23.10	23.60	23.60	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.70	0.72	-4.26	44	1196	2012-10-10 13:59:34	2006-08-30 14:03:34	6	10	1013	13	105	527	12	81.20	43	43.97	CHANGED	KphPlascsolPphhhpcH...NTKsGsauplsVlpGpL+ahths-ptt...spclhhssspsshstPphWH+VEsho-Dhchplc	......+phPhWsKpThPtulhp+H...sT+sGsas+LoVhcGslKahshs-.....Ets.pssphlhhsuuphsh.hsPptWHplEshTDDspapl-.........	0	10	37	74
+9146	PF09314	DUF1972		Domain of unknown function (DUF1972)	Sammut SJ	anon	Pfam-B_3020 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in bacterial glycosyltransferases and rhamnosyltransferases.	21.10	21.10	24.00	23.10	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.20	0.71	-4.83	12	494	2012-10-03 16:42:30	2006-08-30 14:34:02	6	7	403	0	103	539	148	177.60	41	47.78	CHANGED	hpcVaIIGS+GlPA+YGGFETFVEcLlcaQpsp.sIpYaVAChu-sptpp.....pFcYpGADCFsIssPplGsA+sIhYDhhAIphAlchsKppp.ppPIFYILGsoIGsFIs.at+pI+plGGplalNPDGlEW+RuKWutPVppYLKaSEKlMsKaADLlIsDNpsIEpYIpscYs...scTpaIAYGTD	....................................................................................................ppVaIIGo+GlPApYGGFE....TFVEcLs.p..h...p.p..s............p...sI.p........YaV.uCh.......s.c...s....p.s.t.p..........................phca.pGs.csas..l..s..s.P..p...l...G.s...A.c...sIsYD.hh...AlphAlph.h+pp.t....pts.I.hY....lLuss..lGs.Fl.h.shh+pI+phGsp.l.hlNPDGhEWcR.u.KWut.sV.+pYh...........KhSEphMsKaADllIsDspsIcpYlppcYs...........scTsaIAYGsD......................	0	25	61	79
+9147	PF09315	DUF1973		Domain of unknown function (DUF1973)	Sammut SJ	anon	Pfam-B_3022 (release 20.0)	Family	Members of his family of functionally uncharacterised domains are found in various eukaryotic calcium-dependent chloride channels.	21.00	21.00	21.60	21.50	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.18	0.71	-4.84	13	287	2012-10-03 16:25:20	2006-08-30 14:51:31	6	17	61	0	185	287	1	171.20	37	20.05	CHANGED	ulQLESpG...slpsschlsGTVsVDSTVGsDThFLlTWssp..sPpIh...LtDPsG+pYso..FhsD.tss+sApLpIPGT.AcsGsWTYoL.ptpsssQsLTlTVTSRAuSsolPPlslsA+hspcoupaPSPhlVYAcVpQGhLPlLuAsVTAhI............EopsG+sV..TLcLLDNGAG.ADssKNDGIYSR	................................................................................lQl.Sps....plpspthhssoVhlDuoVGp-ThFllT.Wssp..............P.p..Ih.....LhDP.sGphhss..............Ft.hD....hs...+hutLp.I.P...G.....s...Ac...sGtWsYol............pt......p...ss..s...ps......l....ol.........TVT..SR..As......s.s........s.s......s......Pl.o.....Vsu...th...s...p...ss...sp....a.....P...s...P....h.l..lYApVpQGh..hPlLu..AsVTA.hI..............E.spsGp.s.s.....sLcL.hDNG.A....G..A....DshKsDGlYSR......................	0	86	92	118
+9148	PF09316	Cmyb_C		C-myb, C-terminal	Sammut SJ	anon	Pfam-B_3027 (release 20.0)	Family	Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis [1].	20.30	20.30	20.90	20.90	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.38	0.71	-4.58	15	288	2009-01-15 18:05:59	2006-08-31 09:38:54	5	26	77	0	111	268	0	154.40	46	24.59	CHANGED	FSPSQFLNtsspp-shsl-sssLTSTPVC.uQKsh.oTsLpRDpTP.hhQKENuhFRTPsl+RSll-sTPRTPTPFKsALsh.-cKYGPLKhlspTP.aLEEDlpEVl+pEsspslIlt-psc...PhhKK...tKQ.phcSP..hKKVRKSLsLchh-.pch..ssphhspsss.scptPs	...........................................................FSPSQFL.Nssssp.-phsl..EsPoLTSTPls.upKlhlTTP....hH+-p.Ts.+....sQKEN....ss.......FRTP.s...h+RS.l..lp.soPRTPTPFKsALAsQEtKYGPLK...h.l..P...QoPuaL.EDlpEVlKpEospsh....hl.t..-.pc....................P.h++.........hKQ.phpoP..scKstp.hs..ctW-t-ph...ssphhsps.s.......p........................................................................	0	15	23	54
+9149	PF09317	DUF1974		Domain of unknown function (DUF1974)	Sammut SJ	anon	Pfam-B_3029 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are predominantly found in various prokaryotic acyl-coenzyme a dehydrogenases. 	25.00	25.00	28.20	26.30	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.80	0.70	-5.00	103	1236	2009-01-15 18:05:59	2006-08-31 10:02:30	6	6	996	0	224	886	173	278.60	50	35.24	CHANGED	lRCHPYlLcEhpAutssDp.ppuLcpFDchlhuHlGashsNshRuhhhuLTuuphu.suP.....ssstoppYY+plsRhSAuhAlhuDluMhsLGGsLKR+EhlSARLGDlLSpLYLuSAsLKRa-Dc...GR.ppDlPhl+auhpcsLhphppAhcchlpNFP.s+hluhlLRhl.lFPhGp.p..hptPSDcLspclAchlh...pPus..sRcRLspsh.Ylsp......s......csss.lGtlEpAapshhps-slhcKlpcAh+...tsplshh......phpphhptAlctGlIopsEschLpcscthRhcsIpVD-F	.................................IRCHPYVLcEMpAApss..D.....lpsFDclLFpHIGassSNtlRShWLGLTtGhho..ssP.......ssssT+RYYppLNRlSAsLALLuDlSMulLGGuLKRRERlSARLGDlLSpLYLASAs.LKRY-DE....GRpc.uDLPLVHWulQDuLapAEpAhD-lLpNFP...NR.sl.uulL+sl...lF.P.hG...R...+...ahuPSD+L-cclAclLQ...sPsu..oRsRls+Gp.Ylss.....u..............-csP.VGhlEpALhslluA-Plap+lsKtlt.pplPhp.........pL-clscpALtpGlIsp-EAslLhcAEctRh+uIsVDDF...............................................................	0	52	102	172
+9150	PF09318	DUF1975		Domain of unknown function (DUF1975)	Sammut SJ	anon	Pfam-B_3057 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are predominantly found in the N-terminal region of various prokaryotic alpha-glucosyltransferases.	26.80	26.80	26.90	27.10	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.43	0.71	-4.71	51	2040	2009-01-15 18:05:59	2006-08-31 10:17:07	5	3	483	0	135	1104	1	188.20	20	38.94	CHANGED	hhYhlspslshssSGlEhAthtRhplFcp.hshssKhlhhsap..splpphhcphsh.....pc.scllshY-aFpch...hsssptt.hsh...cplsh.pthphttss..thhphh............ps.phhhtlhhtspp...phlppl-ahs.pspl.l++-hashpGahSphthast.ssclhhcpaas.-Gphhhcchh.tspptt.phs...h.........hhFps	...............................................a.h...l..t.ss...s.h.ph.placp.hsh....sschlhhs...at......plp.p.h.hpphsh...............hs.schhsh.Y..s..aFpsh.....ht.pptt.hsh..........pplsh........t...t.hchhtss......p.hc.lhs....................ps....phh....s.ph.aaps.p..t......phlphl-aac..p..spl.h++-.hYstpGhhSshph.....hss..p.....s......c......hhh....cpaas.pGphhlpchh...s..sptt...h.....hhh..tt.........................................................	0	43	57	115
+9152	PF09320	DUF1977		Domain of unknown function (DUF1977)	Sammut SJ	anon	Pfam-B_3043 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are predominantly found in dnaj-like proteins.	20.90	20.90	20.90	21.10	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.42	0.72	-3.80	29	448	2009-01-15 18:05:59	2006-08-31 10:32:53	6	9	265	0	284	412	2	105.10	31	28.52	CHANGED	lluphhss........sPs.YSh..p.o.tashpRpTsphpVsYYVsp..sFppca.....susplppLEppVEp-YlppL+psChpEppp+..........................pphh.tAp..hhtDpc..hhpcApphphP.sCccLpcl	......................loplhso........sPs..YSL........pso..ssa..s.hcR...pT.p.......p..l..p....V....sYYVsp..sFp.pcY..................puspLppl.EcpVEcDYlspL+psCh+Eppp+..........................pphh.tAp.....hatDtc....hhpcApphths...sCpcLpp..............................................	0	78	129	206
+9153	PF09321	DUF1978		Domain of unknown function (DUF1978)	Sammut SJ	anon	Pfam-B_3044 (release 20.0)	Family	Members of this family are found in various hypothetical proteins produced by the bacterium Chlamydia pneumoniae. Their exact function has not, as yet, been identified.	25.10	25.10	25.20	63.70	23.20	25.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.69	0.70	-4.93	6	49	2009-09-14 14:09:44	2006-08-31 10:41:27	5	4	2	0	25	49	0	196.80	38	35.96	CHANGED	cDcpKsupAcpcatEht-phcca+KshFWLsE-ssIDh...ossssWshst.PpRps..........hsclspcEh...Wp+pstLK+hcspYspshsphpcpsoccNpptLp-tppch.cthp-happEhccscpRlcsLpthYspl.sspp-sctppphs..h.......cL-phh-pIEpphppssc-Q-sYWKpp-s+E....tEh+Ectsctcp.cEhpcsLct......L-chl+pppcpLchlctclpctphphst.sspppLpsu	.......cDcsKSupAEp+hp-hp-pWcca+cslFWVcE-GshDl....shh.usWshsh.PhRpt.........RhsclshHEl...a-cThhlKch.cpphshA+sthEKptSpcN.pthpchptth.p.hpchhtpEhpcstpRlcpLpthYstl.sp..-tchppph...........sL-phhttl-pphppssp-Q-.Yhc..-.pE.....Ehctphsphh..cph.p.hp.......h-phlcth.ppL..hph.h.tht..hpt..t.h.lp.........	0	0	0	25
+9154	PF09322	DUF1979		Domain of unknown function (DUF1979)	Sammut SJ	anon	Pfam-B_3053 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in various Oryza sativa mutator-like transposases.	25.00	25.00	32.20	31.70	21.40	16.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.80	0.72	-4.33	3	157	2009-01-15 18:05:59	2006-08-31 10:53:18	5	17	4	0	87	153	0	57.80	75	4.81	CHANGED	MSSKlhFchaaGEGNVRaGPsGVDLSDFlsooRGIDRPAERSFpSIpNWLMRGFRIDP	....MSsKlhFQlhHGpGNlRaGPsGVDLSDFlhTu+GIDRPAERohpSIhuWLhRGhRlD..................	0	0	0	2
+9155	PF09323	DUF1980		Domain of unknown function (DUF1980)	Sammut SJ	anon	Pfam-B_3062 (release 20.0)	Family	Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function, has not, as yet, been defined.	25.60	25.60	25.60	25.90	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.99	0.71	-4.54	29	841	2009-01-15 18:05:59	2006-08-31 11:00:14	5	1	748	0	102	467	0	173.80	37	63.92	CHANGED	hlRhLILhGashlhhaLhloGclspaIss+ashhshhuhllhhILullQlhhhhpshcpp..................cpH..t....t+hhshhlhllPllhGhh....hPssoLD......SshsstKGhphsh........ts....tscptopsphl+s-..............stt.htp.hpt.h.pphhtpppIpls--sahcsh-tI..hp.s.scahG+	..............MlRhllLhGah.LhhaL.plSGcLspYINh+YsYLuhlohll.hlLA...l..VQlh....l....hh+...phc.p.............................HsHh.ps+........t+hhuhsLLslPlllGlh...........FPoloLD..................................Ssh.V...sAKGapFPl..........................utts....ps.s..tts..p..sQaL+PD.............................TS.Ya.scs....sYcctM.ppth.cca..hsp..ssIplssENYhcsMEhI.YsYP.s-FtGK........................................	0	30	70	85
+9156	PF09324	DUF1981		Domain of unknown function (DUF1981)	Sammut SJ	anon	Pfam-B_3041 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in various plant and yeast protein transport proteins.	20.90	20.90	20.90	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.71	0.72	-4.46	41	681	2009-01-15 18:05:59	2006-08-31 11:31:41	5	13	272	0	470	659	6	83.80	34	4.95	CHANGED	h+FLcp-ELspap.FQ+-FLpPFEhlh.....pps..psh-l+-hlLpCltphlps+s..spl+SGW+slFsllshuuppps-pllphuap....llph.l	...............................+Fh-ctELspFp.FQc-FL+P..FEplh......pps..pssslR-h...llcCltQh..lpupu..ssI.+SG.W+slF...uVhptAus...-....p....p.csllphAFppht...................................................	1	163	245	367
+9157	PF09325	Vps5		Vps5 C terminal like	Mistry J, Wood V	anon	Pfam-B_6206 (release 20.0)	Domain	Vps5 is a sorting nexin that functions in membrane trafficking. This is the C terminal dimerisation domain [1].	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.27	0.70	-5.11	22	1147	2012-10-03 12:17:00	2006-08-31 11:48:15	5	17	292	0	720	1151	2	193.30	20	42.46	CHANGED	htphhsshtpulst........shKhsEs.....DpaF.-+pphl-sLEppL+pLhcul-slsspRp-Lutshs-hupulstLussE.s..psLSpsLspLu-lpt+lcphhpcputpDhhpLuthlc-YlRhluSlKssFspRhKhapphppsppsLpKK+pphsKhpts.tsp..t-KhpphppElp-hcp+sppscpcFccloppl+cElp.+F-p-+hcDFKsslptaLEutlcsQcEhl-hWEsFhsp	..................................................................................h........................th..p-.............D.hF.p........tt.h.ph.cpplp.p.h.pttsc.ph.spp..+.c.......plutshs..phutshtt.Lu......t.....E...t.p................s..l.......s..p........s.......h.......pplu.......c.h.p.......ph..pp......h......t........p.c.....u.....ps.-.hph........sch...lp.Yhp.ht.......ul+sh.hppR.pth..php.pspptLpct...+tt..t.....ch....................................h.......t.....................................................p...............c...+hp.p....h..................t....cl.t.p..............hp.....tp.p..thp.......pphcpl.s.......p....h...pp..Eh..cap....pp+htsh+p.lhphhp..lphtpp....ht............................................	0	198	345	556
+9158	PF09326	DUF1982		Domain of unknown function (DUF1982)	Sammut SJ	anon	Pfam-B_3077 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in the C-terminal region of various prokaryotic NADH dehydrogenases.	25.00	25.00	28.00	26.70	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.70	0.72	-3.81	98	630	2009-01-15 18:05:59	2006-08-31 12:44:19	6	11	567	0	299	594	813	49.80	34	7.25	CHANGED	Dpltssshts.hsh.h..........splup..ss.F...psslpDFYhTsPIuRASssMAcC	.............................Dpltsss.htp.hss...............hssphss..ss.h......ptslcDFYhT.ssIoRASssMAcC..	0	96	171	232
+9159	PF09327	DUF1983		Domain of unknown function (DUF1983)	Sammut SJ	anon	Pfam-B_3073 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in various bacteriophage host specificity proteins.	20.90	20.90	20.90	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.64	0.72	-4.03	47	1596	2009-01-15 18:05:59	2006-08-31 12:57:54	6	28	644	0	69	1683	37	78.60	46	8.51	CHANGED	lpptupuhsshsG....clsAhaslKsps.sssGphhsAGhuluh-.sssusspSpllltADRFull...ss..ssGshtsP......FVlp..sG..plal	.......................................................................lpphp+s.hDsNs.........phsAMWul.Klpp.spD.G..phY.l.A.GIGhuhE.sTss..s.........hhSQlLluADRIAhI....sP...ssGNp..pPh......FVuQ..GsQlFM............	0	7	22	45
+9160	PF09328	Phytochelatin_C	DUF1984; 	Domain of unknown function (DUF1984)	Sammut SJ, Bateman A	anon	Pfam-B_3070 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found at the C-terminus of plant phytochelatin synthases.	25.00	25.00	26.20	78.80	21.10	24.70	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.82	0.70	-4.90	14	95	2009-01-15 18:05:59	2006-08-31 13:15:16	5	3	42	0	22	104	0	238.20	45	54.33	CHANGED	p+sPulLYTLSC+cESWhuhAKYLhEDVPhLLpScslcslpclLSslhcSLPuNhspFIKWVAEVRRpE-Gs.psLScEEKpRLtlKpcVLpQVp-TcLF+hVschLpp.pt.stp.stsstcDSLs.plAAsVCCQGAslLsGp.hsussthCC+c.Tsh+slcus.GcsssTVlSGsVl..ssssEQuVDhLlPhs.tpssssss.........t.stp..hhHPossDVLTlLLLALPPpTWtsIcDcpLhsElpsLVSp-sLPslLQcEV.LHLR.cQL	...................+.sshLaTLSCKcpsWhuhuKYLhE-VPhLL+ScslssVccll.slhpSLPushspFIKWlsEVRhtE-Gs.ppLSpEEppRLtlKpcVLpQl+pTcLFphlscaLpp........s.ssp--SLs.phAApsCCQGAthLs..Gs..s.SsthCs+c.sshpslpus..ucu.ssVloGpVl..ssGsEQslDhLVPpp.sps.s.ssss.........t.s.p..shaPossDlLTVLLLALPPpTWpsIpDpplhtEhppLlSpcpLPs.LQpEV.hHLpcQ.......	0	3	14	17
+9161	PF09329	zf-primase		Primase zinc finger	Mistrj J, Wood V	anon	Pfam-B_9710 (release 20.0)	Domain	This zinc finger is found in yeast Mcm10 proteins and DnaG-type primases [1].	21.80	21.80	21.80	23.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.44	0.72	-4.36	37	283	2009-01-15 18:05:59	2006-08-31 13:27:25	6	12	258	4	201	287	3	46.00	37	6.37	CHANGED	GpupDhGhCpuh+.+sGphCsshlNt.....pcspaCpaHhphp....h++h.pupR	.....GpupDlGhCKuh+..KsGch...CsshVNh.......pcs-aCpaHlptp....h+Kh.putR...........	0	58	101	164
+9162	PF09330	Lact-deh-memb		D-lactate dehydrogenase, membrane binding	Sammut SJ	anon	pdb_1f0x	Domain	Members of this family are predominantly found in prokaryotic D-lactate dehydrogenase, forming the cap-membrane-binding domain, which consists of a large seven-stranded antiparallel beta-sheet flanked on both sides by alpha-helices. They allow for membrane association [1].	25.00	25.00	70.10	61.00	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.81	0.70	-5.03	19	896	2012-10-02 00:48:38	2006-08-31 13:47:55	6	2	874	2	110	550	214	277.90	68	51.68	CHANGED	VFYIGTNssscLTclRRclLssFcsLPluGEYhHRDhFDIA-KYGKDTFlhIcphGTcpLP+hFulKuplDshhp+lsalscaloD+lMQhhuclhPsHLPcRMp-aR-+YEHHLlLKMuscGlpEA+paLcpaFucus..GsaFECos-EGp+AaLHRFAAAGAAIRYcslHpscVEDIlALDIALRRNDc-WhEpLPtEIsspllcKLYYGHFhCHVFHQDYIlKKGsDsptlc+cMLcLLDpRGAcYPAEHNVGHLYcAcssLppFY+cLDPTNoFNPGIGKTSKpKpW	..................VFYIGTNpPpVLT-IRRHI.LusFcsLPVAGEYMHRDIYDIAEcYGKDTFLMIDKLGT.D+..hPhFFsLKGRsDAhL-KVpF.htsHFTDRsMQphu+LFPuHLP.RM+saRDKYEHHLlLKMuG.DG.......VuEA+paL............t-a..F............ppA.....-......Gs....FFsCTsEEGsK...AF.LHRFAA..AGAAIRY.pA.VHuDEV.EDILALDIALRRNDp-WaE+LPPEIDspLlHKLYYGHFMCaVFHQDYIVKKGVDs+A.............LKcpMLcLLppRGAQYPAEHNVGHLYcA.poLp+FYRc.DPTNShNPGIGKTSK+KpW..................	0	20	49	82
+9163	PF09331	DUF1985		Domain of unknown function (DUF1985)	Sammut SJ	anon	Pfam-B_3094 (release 20.0)	Family	Members of this family of functionally uncharacterised domains are found in a set of Arabidopsis thaliana hypothetical proteins.	29.80	29.80	30.10	30.50	29.50	29.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.72	0.71	-4.38	50	173	2009-01-15 18:05:59	2006-08-31 14:19:20	6	13	9	0	34	177	0	119.50	24	17.19	CHANGED	LLsRpLhscKcpE.hWhlhuGpPlRFSlcEFtllTGLsCtphPpphcsppttph........shhpph....h...t.ppshsltclhphLppt.......hhsstp+lpluhlhhlsullhsppphst....lp..hhchsp-lchhhsaPWG+h.uFpt.hhpsl	.........................................hh.pph.hpp..p.hWhhhss.PlRaulpEathlTGL.Ct.hspp.p....th.th...........thhtph....h...h.pps.hshtcl.phL.tt.......thps.tp+lphuhlhllpullhsppptst....ls..hlchspslchhhpaPWGchuFphhhpt.....................................................................	0	12	13	13
+9164	PF09332	Mcm10		Mcm10 replication factor	Mistry J, Wood V	anon	manual	Domain	Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha [1].	20.10	20.10	20.40	22.10	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.59	0.70	-5.10	9	127	2009-01-15 18:05:59	2006-08-31 15:11:39	6	8	106	1	85	126	3	292.30	32	37.32	CHANGED	holPTsGhhplppc.....tpu.httsGsshpShSAspLLKpQ+ppp.phLthh+ccuEclQK+......hLpSostscssSpsooo.......pushpoPptus-h.pspth....ssoPKLuRuhs.u.Dl.Fhscpss...t.supu.pAtKhAAltKL+A....LtKtsPN.lK+Kpupouc.h.lsptVcpp.......ssuu.....ppus--pEPthKKcR......p.cEhp+ILsAKSpHosllcttEtEhQEcYFssL.+KEphEEKMpshhEhp.C+sVTCppCKYTtFpsu-cClpEpHch+hHDAsKRFF+Cs.CGNRTloLtRLPKppCusCsh.KWERsuMl+EKpG.plGGEsLhsRGEEc.KFLsS	.......................................................................................................................................t.....t......p.hss.th.tppp.p....h.h..h.ttp...ttthp........hhtsstt.........s........................s.ph.p....p...t............s.s..hPpLupu..t..u.pl.h.hs...tp............s.u.......K..hsAlh+h+s...........ltK.sPN.h...p.p+t..tpstc....t....lp.ptscpp................t..s............pcp.c.t.++p+.......................pp-ph...pcl...l..p.A+SpHssllcpsEt-hpEcYFp.L.+KEpMEEKMpshpEhp.C+sVpCcp..C..p.YTtFpss-pChpcpHs.l+.h+DulKRFF+Cs..tCGpR..ol.ol.p.+.l.Pp.p...pCps..Cs.......+.WERsuM..........h+...E.....+p......s..hhstEtL..RG-Ec.pFlsS....................................................	1	30	39	66
+9165	PF09333	ATG_C		ATG C terminal domain	Mistry J, Wood V	anon	Pfam-B_61662 (release 20.0)	Family	ATG2 (also known as Apg2) is a peripheral membrane protein.  It functions in both cytoplasm to vacuole targeting and autophagy [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.01	0.72	-3.84	36	689	2009-01-15 18:05:59	2006-09-01 09:08:59	6	33	269	0	463	699	7	95.20	27	4.20	CHANGED	+thSlYusQ...PtslppGlppAYpoLpc..............................slthstpslhpsstch..hc....spuspuA..........stsVl+tsPssllRPhIGuT-AlupsLhGlpNplDPppppc.c-KYK	..................................................................p...phhspp....Ptslt-Glspuhpultc..............................ulhsu...hsulhppPhcs....tc...........pcGssG..h..........................hpGVs+ulss.sls+PhhGss-hsSpshtGlcN.......ph..................................	0	164	244	364
+9166	PF09334	tRNA-synt_1g		tRNA synthetases class I (M)	Bateman A	anon	Pfam-B_107 (release 20.0)	Family	This family includes methionyl tRNA synthetases.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.33	0.70	-5.81	39	7775	2012-10-02 18:00:56	2006-09-01 16:59:03	6	66	5004	42	2168	33465	18847	310.30	30	47.26	CHANGED	hhlTosl.YsNussHlGHhh.ohlsADlhsRapRlp.Gp-.VhFlsGoDEHGp.IphpApcpGloPpchs-c.hpptapchacp.hsIsaDtFhRTTsppHpchspchapcLhcpGhIactphpthYsssscp..Fls-+.................upCP................tCG+plc.................hh+.pcpaFFcLscapct....................Lhcal.cps.t....psphpphs.sal..cpGLc-huIo...pchsW.GI.l.....P.....ssps+slYVWhDAhlsYloust.hs....................c.pa....pcaW.....p.....t.hHhIGKDIlhFHslaWPAhLhu..........tshp.......lPpplhupualsh-Gp.KhSKSpGsslps.pchlcp.as..sDhlRYaLhp.psshspDscFShcchhp+lNs-LssslGNhlsRsh	........................................................................................................................................................hlTsslsYss.G........t........l.Hl.GHhh..shltu.Dlhu.R.a.........p.R....h....p......G............h.........s..........V.....h..........a.........l...............s.........G..........s.................D........t..H.........G.............t...........................l......p..........t...............t.............A.................t............p..................t..................G......................h................s....................P.................p.................p.................h.....................s.................c.................c................h.................t................t.................p.................h............p............p........................h................p............t..............h................s..................l.................S............a...............D............p.............a.............h.........p....................T.............o....s......s......p......a..........t....c.h....s..p........t.........l.........a....................p...cL...h....c...p...G..............Ih...p.t.p.h.p.....t...h.a..s..s..p..p...p...p....a...h.s-p......................................l.t.t...h.................................................sut......h..p...........................................................................h..p.....p..cpaFhc..l..s..t.......h..t..p.h........................L..t.ah....p.......t.....t.................p....h.......ph....h....pa.h...............p.....s......L.p......t...hslo........ps..h........a.Gh...l.........P......................................tt.t+h..h..Y.V..........W........h......D........A...........h.....s.......Y...h..s.....sht..t...............................................................a.............pp.a...W.................................................................h.p.....h..h.......GK.........D......l...................h....F...........H...s....l...h....a....P...h..h.L.u..............................th..................................h.P.....p.p.....l.....h.s..p.t.....a.....h.....h.....h........p......s......t......K.hS.K...........S.....h..Gs..h.l..s................h...l..........p...............p......h.s................-......hR.....Y..a.hh......t...................s........h.....p.D.h.sh......s......p......t..h..h..t...p..h.N......-..lssthsNhhsRs.h..................................................................................................................................................................................................	1	764	1399	1855
+9167	PF09335	SNARE_assoc		SNARE associated Golgi protein	Mistry J, Wood V	anon	manual	Family	This is a family of SNARE associated Golgi proteins.  The yeast member of this family (Swiss:P36164) localises with the t-SNARE Tlg2 [1].	32.60	32.60	32.60	32.60	32.50	32.50	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.50	0.71	-3.91	83	15761	2009-01-15 18:05:59	2006-09-01 17:20:35	6	40	4479	0	3638	10044	3069	125.40	20	54.58	CHANGED	lP....sthlh..hsuGhhh........uhhh.....uhlhshlGshlGshlsahlu+hht.............pthhpphhpppthpt...hpphh.........pc..huh.hh............lhlhRhlPhlstshls..hhuGh.splsh.tpFhhsshlGthshshlhshhGth	.................................................................................lP..uphlh......hh.u.G..h.l.h......................shhh.......................shlhshl.uu...h...lGsh....lsa...h.l.G.Rh.hG.............................phhhp...h...h..h..p..p..p..t.....h...p..p.............s..pph.h......................p+...aG...h..hs....................................lll.s.R..a.lP..h.l...psh..ls...hs.AGh..s.p.hs......h.tp.FhhhshlGsh.hhshlhshhG..h..........................................	0	1172	2266	3020
+9168	PF09336	Vps4_C		Vps4 C terminal oligomerisation domain	Mistry J, Wood V	anon	Pfam-B_8681 (release 20.0)	Domain	This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerisation [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.87	0.72	-4.08	26	1201	2009-01-15 18:05:59	2006-09-04 10:04:39	5	14	381	41	789	1144	12	54.50	29	9.96	CHANGED	hlTPCSPGDPs.A.lEMoWh-ls....uccLhEP.slThpDFlKAlpss+PTVspcDlc+apcFTc-FG	.........................h............................p..l.......tpch......P..slshpDFpcAlpps..+sSVSppDlc+aEcasp-FG.................	0	272	408	623
+9169	PF09337	zf-H2C2		His(2)-Cys(2) zinc finger	Mistry J, Wood V	anon	manual	Domain	This domain binds to histone upstream activating sequence (UAS) elements that are found in histone gene promoters [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.05	0.72	-4.54	11	664	2009-01-15 18:05:59	2006-09-04 13:23:51	5	42	181	0	194	519	2	39.20	51	10.82	CHANGED	Hhpp.HuGINKoTotIApKYHWhRIKETVucVI+sCscCK	............HslA.HoGp-u.Tah..KloSKYaWPNlRKDVlKVIRQCcQC.h..	0	88	124	161
+9170	PF09338	Gly_reductase		Glycine/sarcosine/betaine reductase component B subunits	Mistry J	anon	Pfam-B_25756 (release 20.0)	Family	This is a family of glycine reductase, sarcosine reductase and betaine reductases.  These enzymes catalyse the following reactions.  sarcosine reductase: Acetyl phosphate + methylamine + thioredoxin disulphide = N-methylglycine + phosphate + thioredoxin Acetyl phosphate + NH(3) + thioredoxin disulphide = glycine + phosphate + thioredoxin. betaine reductase: Acetyl phosphate + trimethylamine + thioredoxin disulphide = N,N,N-trimethylglycine + phosphate + thioredoxin [1].	20.00	20.00	20.30	20.70	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.32	0.70	-6.30	16	404	2009-01-15 18:05:59	2006-09-06 15:52:04	6	3	133	0	71	362	11	324.90	29	81.50	CHANGED	M+LELGpIaIKDlpFGcpTcVcsGVLhlNKcEllchltp.D-+Ipol-l-IA+PGESlRIhPVKDVIEPRVKVEGsGslFPGhhuKV-.TVGpGRTHlLKGsAVV............ToGcIVG.FQEGIIDMSGsGAcYTPFS+hhNlVlls-sh-Glppa-HEp...AlRhsGLKAAtYLGEAu+slpPDElcsYETpPlhEpspcYPsLPKVuYVYMLQSQ..GLLHDTYVYGVDAKpIlPTllYPTEVMDGAIlSGNCVSACDKNsTYlH.NNPlIc-LYc+HGK-lNFlGVIlT.NENVhLADKERSSsasAKLschLGhDGsIlSEEGFGNPDsDLlMNC+KlEpcGIKTVllTDEaAGRDGsSQS.LADusscAsAVVosGNANpllhLPsM-KlIGcl..phl-slAGGasG......SL+tDGSI-sElQAIsGATsElGFspLoA+sY	.....................................................................................Lphtphhlpclpaup..pop.l.c.sssLhl.pc.p.h.th..h.t.....cphl.pphclcl.hpPs-.t.h.p.h..s.hh-slps.ts+hpGt......................lGpGhThsL.pG.shVh............hs..G........p............hu....p..-Gh.l-....t.h...h..s..t..s.....h....s.....t........plhl.hp........th..p.....ht..pt....h.hhu...hchs..a.l.s....p...hc.t....h...p...s..-..p.......h.ph..hhp.t.t....hsth.pVshlh.h.sQ....Ghha-s.........hhh.........G....h...p......hh.....th...........l.....Ps.hh.PpElhDGul.huh...shlusssKpsohpahppPll.cplhpccsp-lshhGVlhs.sps.h.s-K.hsuphsuthsc.hhssDGsllop.EGaG.NschDhh.shcplttpGl.sVhlo..........................................................................................................................................................................................................................................................................	1	42	66	68
+9171	PF09339	HTH_IclR		IclR helix-turn-helix domain	Bateman A	anon	Pfam-B_70 (release 18.0)	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-7.78	0.72	-4.37	93	11639	2012-10-04 14:01:12	2006-09-12 11:35:16	5	84	2544	26	3363	13801	1334	51.10	26	19.10	CHANGED	ulsRulplLchluppsps........h..sls-lAptsGls+uosaRlLpoLhptGalcpcs	.............................................slt+ultlLc..h...l.s..p.p.s.ss.....................h..sls-.lupp...s.....G..l.s.+.o.TsaRlLpo.LtptGalpp................	0	800	1991	2786
+9172	PF09340	NuA4		Histone acetyltransferase subunit NuA4	Mistry J, Wood V	anon	Pfam-B_29415 (release 20.0)	Family	The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast [1].  NuA4 complexes are highly conserved in eukaryotes and play primary roles in transcription, cellular response to DNA damage, and cell cycle control [2].	20.90	20.90	21.20	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.82	0.72	-4.34	29	357	2009-01-15 18:05:59	2006-09-12 13:53:42	5	8	275	0	236	335	0	80.70	39	40.29	CHANGED	+pcLp.phlp+KppL-ppLssLEcpIYchEspYLp.....tsoshGNIl+.GF-sa..hpsss................ttsp++pttap-sDRlFShSSso.h	...................tcLt.phlp++pplp.cp...LssLEcp......IYshEsuYL-................pophhGNII.+.Ga..DpY...lpspp.......................................sutss+R..pppap-s-RlFSpSSlT...................................	0	85	135	199
+9173	PF09341	Pcc1		Transcription factor Pcc1	Mistry J, Wood V	anon	manual	Family	Pcc1 is a transcription factor that functions in regulating genes involved in cell cycle progression and polarised growth [1].	20.90	20.90	21.30	21.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.31	0.72	-3.94	57	386	2009-01-15 18:05:59	2006-09-12 13:56:42	5	11	320	13	261	415	29	76.60	23	62.38	CHANGED	hphslplsFtotc.AplshpuLps-..sphptspsphphshps.s..............hLh..lphpA........p-sphLRsulNoalc.lplshcshpt	...............................thslplsaso.tc.A..plshpuLtsD....tphp.stsppph....shss.s..................................................................hLh..lphpA............pcs..+hLRsulsualc.lplshcshp......................................	0	72	146	210
+9174	PF09342	DUF1986		Domain of unknown function (DUF1986)	Mistry J, Rawlings ND	anon	Pfam-B_99782 (release 20.0)	Domain	This domain is found in serine proteases and is predicted to contain disulphide bonds (see Swiss:P98159).	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.99	0.70	-5.11	3	34	2012-10-02 13:45:52	2006-09-12 14:19:54	6	16	29	0	24	2142	2	201.90	31	10.89	CHANGED	N++sElV-sFc.....................--hcWPWlAcVYl-GshhCoGVLIDtSWVlVScSCLpslsLcHpYlSVVLGGuKTh+Sl.+GPYEQIhRVDCa+slP+ScllLLHLcoPloFS+HVLPTFVP-opNcNpocu.cCloVGQDD.hGRsKTluIaL.cNsTNCsScpl.CYK+cpKQP.h....lhN..stsMsSpHE.stlISCaTPpthsslscFT.............sss..sLKN.....sScthassS.pGVlV..C+sSRoGWaPsuhapapRGsC.GFccls.GVRoLE-uY+clQ-llHK	.............................................................................................................p.h..h.WPW...L.A.....c...l......a...........s......s.....G......c.....h....h.....Ch.....GlLl-.pWlLsp.puC.......l........p........s......l.......s.......h........p........s.....p......Y...l.......o........s....l.....L......G......t......u....+...........o....h......h.............h........c.........u.......s......a......p......Q.......I...........h..........V.......D.........p........h........c..................l.....................c.............o.............p........l......LL.....HLc.........p.........s.....p....a....o.+..a..V.Ph..hl...c....................t..p..ts.....C......l...u....l..h....p..sp..............p..........o..................t...l..h.....h.............s........p....s....C.....s...........Capht..................................................................................................................................................................................................................................................................	0	8	11	21
+9175	PF09343	DUF2460	CHP2217;	Conserved hypothetical protein 2217 (DUF2460)	Bateman A	anon	PSI2 target BIG_186	Family	This model represents a family of conserved hypothetical proteins. It is usually (but not always) found in apparent phage-derived regions of bacterial chromosomes.	21.90	21.90	21.90	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.12	0.71	-4.96	59	277	2009-01-15 18:05:59	2006-11-08 13:52:02	5	4	254	0	88	226	66	193.60	38	84.33	CHANGED	H-lRFPh..sluhGusGGPERpT-lVsLusGtEcRNssWucuRRRYDAGhGl....RSh--lpsLlAFFEARpGphaGFRa+DhsDapSs.sstsss.tDQhlGh...GDGssspFQLsKsYsu......GtpsYtRsIsKPVsGoV+l.ulsuschttu....tatlDhsoGhloFs..psPssGstloAGFcFDVPVRFDTDplphSlsuFpAGpsP....slPllElRh	................................................H-lpFPh...sluhGusGGP-hpTclVshsoGhEpRNs.WupuRR+a-suhul...........+Shc-lptlluFFEAR+GphauFRa+D.hDapSs..t.................................................................................s.hDQslGp...GDGssspFQLhKsYss..........s.tsYsRsIs+PVsG.oVhl....uVsGschstu....taslDssoG.....lVT..Fs....tsPstssslTAGF..tFDVPVRFDoDplphsls.....sapuGpls.....slPllEl+...........................	0	20	59	68
+9176	PF09344	Cas_CT1975		CT1975-like protein	Bateman A	anon	PSI2 target BIG_184	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family is represented by CT1975 of Chlorobium tepidum.	25.00	25.00	29.30	29.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.06	0.70	-5.08	25	679	2009-01-15 18:05:59	2006-11-08 14:22:11	5	3	640	0	127	467	19	337.10	44	96.95	CHANGED	lplHlLpoassSNLNRDDoGtPKoAhaGGspRsRVSSQuhKRAhRpuhp.tthhst....hG.lRT++lsc..lhctltp................tuh......ctp...Atphscphhsshu.....Klpptppttt...........................coctLhalutpElstluphspcttpsspsspttth......pccpp................................ulDIALFGRMlAs...ss....phNV-AAsQVAHAlosHtlssEsDaFTAVDDLtp....--..sGAuahGssEFsSusFYRYsslDlcpLhcNLGGs.......p.........-hAtcslpAhlcAhspssPoGKQNoaAupshsshlhhph.tpspPhSLAsAFcpPV.......pspcs...hhpsulptLsshhpphcpsYGtt....pshhthsshssptt......s.psolccLlshlt	...................................IplHlLpuaPsuNLNRDDTGuPKTsl.hGGssRlRVSSQSLKRAhRsSthacps..lus........lGlRotRlucc.sAph.L..h-......................pG..l..-pc..cAhchut..plsshhG.............KsKpc+.c..cc..............................................-TcpLlalSssEh-sltsLApphsp-cc.s.sp.ccch.t.....h++cph..................................................................................AVDIAhFGRMLAs...ps.......chNV-AAsQVAHAhulpcs.h.lEsDaFTAVDDLp...........pss.....ED...uGAGHlGpstFuSAlFYpYhsIsh-hLlcN..Luus..............c..............tLAspslcAFs-AhlpssPTGKQNSFAu.+s.hAsaslsph.t.s-.QPhSLAuAF.cP..l......susc.......lpsulp+lsshtcshsplYspp........spssshsl.hspp...ss........................pssh.................................	0	38	93	111
+9177	PF09345	DUF1987		Domain of unknown function (DUF1987)	Bateman A	anon	PSI2 target BIG_79	Domain	This family of proteins are functionally uncharacterised.	21.30	21.30	21.40	22.90	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.29	0.72	-4.20	56	185	2009-01-15 18:05:59	2006-11-08 14:48:30	5	3	128	0	66	195	81	98.00	35	74.40	CHANGED	PpVpFcspsulhclpG-SYsEssh...sFYpPllsWLppYlpp..spptlphsh.cLtYaNTSSo+thhplhchL-ch.tppsspVplsWaap..p-DcchhEhGE-a	.......PtlpaDhpsshLplpG-SYPENuh...tFatPllpalcpYLsp............spp..........s..........lplcl.cLhYhNoSSsKslhslh-hL-ps.tppGppVslpWaY-..p-D-phtEhGE-F................	0	29	47	57
+9178	PF09346	SMI1_KNR4	DUF1988; 	SMI1 / KNR4 family (SUKH-1)	Bateman A	anon	PSI2 target BIG_91	Domain	Proteins in this family are involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation [1][2]. Genome contextual information showed that SMI1 are primary immunity proteins in bacterial toxin systems [3]. 	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.44	0.71	-4.13	178	1863	2012-10-01 20:46:44	2006-11-08 15:03:16	5	30	934	3	480	2059	25	133.60	15	53.86	CHANGED	ssoppplp...p.hEpp..luh.pLPps.a+phlp.........................................tthhhthtshshhthhhtthph..tthtphhphpphhpph..................................................................................................................................h.pphlshus...sssushhslchsstt................splhhhspc........tsp...hthl..................us..oFsca.......lpp	..................................................................hoppplp....p.hEpp.....hs.h....pLPps.apphhp...............................................s.ss..h..h...h...t...h.t...h...p..h..............t......hh......h..ttph........pthtt...h..hp.h...t..thhpt...................................................................................................................................h.tthl..shup.....sssu....s.h..lsl.-hpsst.t...............splh.h.hsp-......................................tpp.........hhhl.......................................up.....sappal..t.................................................................................................................	0	137	283	391
+9179	PF09347	DUF1989		Domain of unknown function (DUF1989)	Bateman A	anon	PSI2 target BIG_202	Domain	This family of proteins are functionally uncharacterised.	20.40	20.40	20.80	20.60	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.68	0.71	-4.80	144	1044	2009-01-15 18:05:59	2006-11-08 15:22:35	5	9	576	7	482	1045	1397	168.80	30	62.00	CHANGED	ppplsutsshuhtlcpGphlRlsDlcGsQssDhlhasAcc.hs.....ERhssscThpht...tsha.lssG..shLhSshs..Rshholl.pDo..........sGhHDslsusCsspp.phh.aut..pph........csCp-Nhhtulu......paG...ls.......pcDlssslNhFhsVsls.ssGp.lphtsshSpsGcaVpLcAEhDll	......................p..hlPutsshuhtlptGphlRlhD...lcGs....QssDhhhasAcs..p.....ERhssscThphp....pssalssG..shLaSshs..RshhoIltDo............................sGhHDsluusCssppsphh.aGp...pph...........csCp-Nhhhulu..............caG..........Ls.............................ppDlssslNhFhslsls.s..........cG..........p.....ht....hpssh.opsGcal-lcAEhDll................................................	0	123	281	393
+9180	PF09348	DUF1990		Domain of unknown function (DUF1990)	Bateman A	anon	PSI2 target BIG_236	Domain	This family of proteins are functionally uncharacterised.	20.70	20.70	20.70	20.70	20.60	20.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.87	0.71	-4.60	30	289	2009-01-15 18:05:59	2006-11-08 15:25:40	5	8	240	0	132	262	2	152.20	33	78.55	CHANGED	oYsplGuotttth...........ss.....GappsctcshlGpGct.......sF-pAspAlhsWphhctuhlplh.....ssspsstsGssVslp.hthh.......hhhhhsssRVlhll.....-Es.........c+hGFuYGTLsGHsEsGEEpFhlch......s.ssGpVahclpAFSRPAph...hu+luhPls.+hhQ+ths++.hhpul	...................................................................................htsot.t.h.........ss........Gaphhchpt.lGpGpt.......tFcpA..spulhpWthpct...uGlpV..................ssspsstsGssVh....lt.hth.........................ltsPsRVVaVh................--s.........................................shtGFuYGTLsGHs...sGEEpFsVch.......c..tsusVahplhuFSRPAsh...hs+hutPls.ph.hQ+hhspR.hhcuh.................................	0	55	101	123
+9181	PF09349	OHCU_decarbox	DUF1991; 	OHCU decarboxylase	Bateman A, Percudani R	anon	PSI2 target BIG_237	Domain	The proteins in this family are OHCU decarboxylase - enzymes of the purine catabolism that catalyse the conversion of OHCU into S(+)-allantoin [1]. This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase (Pfam:PF01014) and step two is catalysed by HIUases (Pfam:PF00576).	20.50	20.50	20.60	20.50	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.00	0.71	-3.94	139	1098	2009-01-15 18:05:59	2006-11-08 15:27:51	5	15	925	26	464	1030	527	154.20	29	57.32	CHANGED	hs...shspspF.stthsslaEpo....sWluctshs.......tp.....sasoh.ssLhsuhtphlpsss....................pppphsllpAHP-Luu+hh.........stpLospSssEQusAGlsph................ssp-hpc.hppLNssYcp+F.GFPFllsV+.....G.ps+.pp....Ilsshp............................pRl.pNs...cpEhppAhpplp+IAthRLpc	............................sthst.pph.htthsslhEps....sWlschAhs...............t+.....Pasoh.ssL...hsshpp.h.h..p.shs.......................pspthsllpAHPcLus+h................ttph..o..s.....pS.s..pEQ..u..uuGl.sp.h................sspphpp..hppLNttYc.p+F.GasFl........l....slc......G....p.s+...pp.....ILsshc............................pRl..pNs......ppEhppAhpplt+IAthRLp...........................................................	0	124	273	377
+9182	PF09350	DUF1992		Domain of unknown function (DUF1992)	Bateman A	anon	PSI2 target BIG_207	Domain	This family of proteins are functionally uncharacterised.	20.60	20.60	20.70	20.70	19.20	20.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.13	0.72	-4.15	74	1227	2009-01-15 18:05:59	2006-11-08 15:29:28	5	11	1099	0	334	771	12	84.10	39	45.09	CHANGED	lsEcpIpcAhpc..G-F-s...LsG.tGKPLs...hccs..shhs.phphth+llpssGhlP.tlpLp+El.............................tp....lpchlsph	.................hAEc+It-Att+....G-FDN...LsG.pGcPL.....L-Ds...Sal..Ps-lRhuYRl....LKNAGh.lPPplE.p+Eh...........................hp.....Lh-hLp..thpp..........................................................................................................	1	97	193	267
+9183	PF09351	DUF1993		Domain of unknown function (DUF1993)	Bateman A	anon	PSI2 target BIG_238	Domain	This family of proteins are functionally uncharacterised.	20.40	20.40	21.50	22.30	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.81	0.71	-4.31	60	472	2012-10-02 14:44:17	2006-11-08 15:31:17	5	8	351	6	234	454	160	160.20	38	87.75	CHANGED	hYssoVPs.ahp.....hLssLsslLcKApsaApspslcsss.LlsuRLhPDMhPLstQVphAs-tA+tssARLu....Gh.....-sP...........shs.DsEso.Fs-LpARIucslsalpulssspl..-usps+slsh......hsspphshsG.p.sYlhsauLPNFYFHloTAYuILR+pGVtlGKtDYlG	.......................hYpholPshhp.hLpsLsslLsKA.pu..a.Apspt.hc..sss.llsuRLhP..D..............Mh......PLstQVphA.sDtA+tss.A..R.Ls....Gh....-sP................phs..DsE..sT.as-LpuRIscTlsaLps..l..s...s.ppl.-us....ps..+..p.l.sl.................hsstshph.s.G.p.sYlhsauLPNFaFHlTTAYsILRHpGVtlGKhDYlG..........	0	39	113	189
+9185	PF09353	DUF1995		Domain of unknown function (DUF1995)	Bateman A	anon	PSI2 target BIG_247	Domain	This family of proteins are functionally uncharacterised.	26.00	26.00	26.50	26.50	25.40	25.90	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.50	0.70	-4.71	39	273	2009-01-15 18:05:59	2006-11-08 16:33:42	5	9	102	0	174	269	140	221.80	21	67.59	CHANGED	L.PssLppA..........hpputpAltsALt..sspsRhp....l-lpFs..sL................plhsluhphhpt...Ltp......ts.pshhllasDuGuuALApR-h.sshs......plhshsphh.st.ts.................t.........chhlhVsPpsh-....l-plEtlscthss.............psllhlNs+L-...Dsu.lG..lG.su.Rph...RcpFluoapssYaLcPL..ps....................GALh+s.aP......ssWplapps......s..ssYphlsphppRPss-plsth	..................................................................................Ppshpph..........htputpAhttAlp......tttt+h.....l-lph.P.....tL.....................................................p.hpluhthhpt...htp...............ps..pthtllaP-s....uts..shAppph.tshs..................hplsslssht..h.t..sts......................................................................s.....chhlhls...Psshp.......lsplcths.pthss...........................+Pll.lh.NscLc......shp.su....................hu...hss.+.ph............+pp..Fl..ssa..ps.....sYhl+sl..ss.....................GslhRs.YP........s.Wplhhcp.........s.spYt..hl.tp..tp.+.Pshpplp.h....................................	0	67	131	161
+9186	PF09354	HNF_C		HNF3 C-terminal domain	Bateman A	anon	PSI2 target BIG_367	Domain	This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterised by the FxIxxIL sequence [1].	20.80	20.80	21.10	21.10	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.81	0.72	-2.83	26	211	2009-01-15 18:05:59	2006-11-09 09:21:50	5	5	86	0	97	189	0	62.20	43	14.86	CHANGED	sHPFSIsNLM..Sspp..............pKh.DlK.sY-th..pY.uuY..............ssh.shshs........psshp.ssshsssss..........YYQ	..NHPFSINNLM..SsEpp.............pKh.DlK.sY-psh...pY..suY..............sus.sss.s.......ssctshc..sss....ss..............YYp............................................................................	0	16	25	52
+9187	PF09355	Phage_Gp19		Phage protein Gp19/Gp15/Gp42	Bateman A	anon	PSI2 target BIG_98	Domain	This family of proteins are functionally uncharacterised. They are found in a variety of bacteriophage.	21.10	21.10	21.30	23.00	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.49	0.71	-4.25	8	161	2009-01-15 18:05:59	2006-11-09 09:41:09	5	1	154	0	13	124	2	113.30	32	84.71	CHANGED	LhRsLcsDEpcRApALLcsVscplRhEhs+sG+DL-shlstcPsYhtsVhpuVsl-lVARslhsusc.EPhuphSEoshsYShSuoYhls......uGGLhIcDSELcpLGL+K.............pRhGslshYGhs	........hhRsLss-.EpspspshLpsspchlRpchs....-LDt.h.....sstcs.hhtsV......lcl.Acslhp..hsc....sP...u...hoET..sGsYoaphoatls......sGsLhIpcpEhcpL.....Glp+.............p.Rhu.h......h..................	1	1	5	9
+9188	PF09356	Phage_BR0599		Phage conserved hypothetical protein BR0599	Bateman A	anon	PSI2 target BIG_187	Family	This entry describes a family of proteins found almost exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA. An apparent exception is Wolbachia pipientis wMel, a bacterial endosymbiont of the fruit fly, which has several candidate phage-related genes physically separate from obvious prophage regions.	20.40	20.40	23.90	22.50	19.70	16.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.87	0.72	-3.84	73	343	2009-01-15 18:05:59	2006-11-09 09:42:31	5	5	305	0	99	303	38	76.40	37	28.73	CHANGED	suaFstGplshhsGsssGhsttl+pcps.......stlpLhpshstslssGDtlplhAGCDK...phsTC+sKFsN..hlNF+GFPalPGpD	............................saFstGhltahsGs.stuhthtlttcts..................stlpLhtsh..slss....G-thplh...sGCDK...ph.sTCcsKFsN..hlNFRGFPalPupD.....	0	20	64	76
+9189	PF09357	RteC		RteC protein	Bateman A	anon	PSI2 target BIG_10	Family	Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer [1].	20.60	20.60	20.70	20.90	18.50	20.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.38	0.70	-4.49	17	391	2009-01-15 18:05:59	2006-11-09 09:46:05	5	2	123	0	52	328	12	175.30	27	80.01	CHANGED	pFFK.hKP.hhu+LlaasclaphEhppPpGshcstppahppclpcLpphhpp...shsFhpYh+sttshhDcpYFsRsphclt..ssphhhppD.pFoTu......aDhhsApllAs-hl.hahscclcthtpt........tt...tpslpWTusKhsLlELIYALpuptslNsGphsIKclushhpplFsl-L.tchY+oYh-lKpRKp.sRTtFLccLp-sL.p+Mpc-D	..............................................................................................................................hhh..phhth..ths...t..t.p...thh.tph.tlp....t......hhtYhc.t.p.hs...h.p......tp.ph......h.hp.s..Fsp.......hp.hhut...s..hh.....tph.............................lpWTust..hsLlELlYuL......sts..s..l...s...s..G....p...h.slpcluthhpplFslcl..sc..hY+hahc.l+pRKt.sRThFLDpLp-pL.c+M.c...............	0	19	42	52
+9190	PF09358	UBA_e1_C		Ubiquitin-activating enzyme e1 C-terminal domain	Bateman A	anon	PSI2 target BIG_346	Domain	This presumed domain found at the C-terminus of Ubiquitin-activating enzyme e1 proteins is functionally uncharacterised.	29.20	29.20	29.40	30.30	29.00	29.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.46	0.71	-3.96	57	525	2009-01-15 18:05:59	2006-11-09 09:54:28	5	25	308	2	345	522	14	123.90	36	12.42	CHANGED	a+NuFlNLALPhhshoEPlsssctph.....pchca...............TlWDRaclpt......s........hTLpchlcahcpch.sLclshlotGs.shLY..ssa.......tcpp-RlshplscLlcplscp......l.stpchlslplssp.D.psspDl.-lPh..l	......YKNuFlNLALPaFuF....oEPlss.s+tca.......pshpa..........................TlWDRaclpu.........p.......hTLp-hlcahccc......s.L-loMlSpGs..uhLY...usa.......s+hp-RL................shpho-lVcplsKp.................ls.sph+tlll-lssp.....D..pss-..DV..-lPhl.....................	0	128	190	271
+9191	PF09359	VTC		VTC domain	Bateman A	anon	PSI2 target BIG_223	Domain	This presumed domain is found in the yeast vacuolar transport chaperone proteins VTC2, VTC3 and VTC4. This domain is also found in a variety of bacterial proteins.	20.80	20.80	22.40	20.90	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.83	0.70	-5.39	44	868	2009-01-15 18:05:59	2006-11-09 09:58:08	5	23	587	8	395	831	403	232.00	26	51.08	CHANGED	sRpshKahlc.cslhpl+ttlh++Lslhsasssp.......................................................s.sIsSlYaDsss.hchYpp+lp+hpsspplRlRWY.up..t.........splFlEpKh+....ppshsst......KpRhplcp+.lpsal..ssp........t.................................................................................................................phpp.pphssElp....hlhpp.pLpPhlpspYpRsAFphss.-splRlolDoslph..........................................................................................................W++h-ls...hp.s...hlttsth..hs..aullElKhps.....................chspWlp-Ll..uchspplspFSKYhpGhAsLa	..................................................R.phKahlp.pphhtl......pthlh..phhsh..assp..................................................................................................t.sIsSlYFD..s..p.hphapp..clp...ph....p..........tpcplRlRhY..st..t.......................splalEhKp+.................................tpshss............KtRh.slp.t.ppspthl.......pGph.................................................................................................................................................htp..pplh.pElth...hh.hpt...pLpPhhhstYpR......pua......t......h..t......-......s...........p....l.R...lolDpslp..................................................................................................................a+phcls.....t.s.....l.tt............hslhElKhps..........................thPtWlpcll......schshtsspFSKaspuht........................................................................	0	147	259	354
+9192	PF09360	zf-CDGSH		Iron-binding zinc finger CDGSH type	Bateman A	anon	PSI2 target BIG_227	Domain	The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family [1]. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, Pfam:PF10660 [2]. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm [3].	21.20	21.20	21.20	22.20	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.37	0.72	-4.12	158	1359	2009-01-15 18:05:59	2006-11-09 09:59:42	5	27	737	21	688	1317	995	42.40	34	41.39	CHANGED	sppsPhtl............................phpp...pphhhCpCGpSp.spPaCDG.oHp	.............................................................t...sPhhl............................p.pp...pphhhCpCtpSp.sh.....PaCDG.SHp...	2	241	412	580
+9193	PF09361	Phasin_2		Phasin protein	Bateman A	anon	PSI2 target BIG_183	Domain	This entry describes a group of small proteins found associated with inclusions in bacterial cells. Most associate with polyhydroxyalkanoate (PHA) inclusions, the most common of which consist of polyhydroxybutyrate (PHB). These are designated granule-associate proteins or phasins.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.01	0.72	-3.99	132	960	2009-01-15 18:05:59	2006-11-09 11:03:55	5	1	504	0	408	873	126	99.50	18	65.25	CHANGED	hcphtstp.+ssh-s....hhshsstshcGhpclsphshphs+sshppuhstscplhusKssp-hhp.l...Qsphspst..hEphlutu+clt-lsspstp-hhcshcsphs	................................................pph.stt.cpsh-s....hhthsphshcu....h....ppl........sp...........hplphs+sshppshsp.h.cph....hs.sK.s...s...pch...hp.h....Qsph.hppt..h-phhs.pu+cltplsppstp-htc.hptph..................	0	92	225	298
+9194	PF09362	DUF1996		Domain of unknown function (DUF1996)	Bateman A	anon	PSI2 target BIG_243	Domain	This family of proteins are functionally uncharacterised.	19.90	19.90	20.00	20.30	19.30	19.80	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.90	0.70	-4.67	63	716	2009-01-15 18:05:59	2006-11-09 16:06:26	5	20	264	0	462	652	24	214.10	31	52.22	CHANGED	DPlVsPGth.ou.HlHplhGusuFshsh.s...h-.hppusCToCshsp.DhSsYWs.....ssLYa.ct.pN.........Goh..chVP.................GuhslYYhtt..............ttslpAFP...Ga.....RMlsGssttp....................t.tts...tptslsapChsstttt.........................spsaPspsCs......sG....lptslhFPoCWD.GpsLD.o.sc..................HpoHhAYPs....th.s.....sGs.CPsuaPl+lPplhaEshWDTstassts...t...ssFshSs..............GDs..oGYuhHuDFl.GW	...............................Dslh.PG...ss.HhHphhG..s................ss........hshs..s......hp.ht.tu..s..sToC......p.pt.DhSsYWs.........Ps.lhh........s............G.p.h..hss..................uthp.sYYhtt.............................ttlpsFPt.....G..h+h.lsGcsptp.................................hsppslsatChssps.t............................t.ths.s..p...Cs......sG....lphp...lhFP......s..CWD.GhsL-.o..sc.............................a+sHhuYss.............t........tGt.CP.s.s.aP.l+lPplhhclhWsss...t.hs...s.ht.............p.h.hhS...................G.......ouashHuDF..htGW.............................................................	1	164	312	412
+9195	PF09363	XFP_C		XFP C-terminal domain	Wood V, Bateman A	anon	Wood V	Family	Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22 [1].	21.20	21.20	21.60	21.80	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.18	0.71	-4.89	93	1022	2009-01-15 18:05:59	2006-11-10 17:50:17	5	13	862	16	389	968	40	198.30	45	25.77	CHANGED	KQPp.QaLoh-pAhpHCspGlGIW-WAS.sD....putE...PDVVhAsAGDlPThEsLAAlslLRcphP-LKlRhVNVVDLh+Lpsp..s..-HPHGLSDc-F.......DslF.TsDKPVIFAFHGYPhLIH+LsY+RsNppNlHVRGY+EcGohTTPFDMsVhNclDRF+LshDslcRlPp....ltspuutlppphccplhcH+pYlpcaGpDhPElpsWpWs	.........KQPp.QaLoh-EAtpcsspGlulW-.WAS..s-...........ps.tE..........PDVVhAsuGDhPThEsLAAlslL+..............cphP-..LKlRhVNVVDLh+Lpss.........p....p+P+GLSDc-F.......DslF..Tp.DKPVlFAaHGYshLI+cLhacRs...N....t...c..NlHV+GYcEc.................GshTTPFDM.tVlNclDRF+Lsh-slc....clst....................htspuuth....hpph....pstlhcH+pYl+cpGp.DhPElpsWpW..............................................	0	98	230	324
+9196	PF09364	XFP_N		XFP N-terminal domain	Wood V, Bateman A	anon	Wood V	Family	Bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyeraldehyde-3-P EC:4.1.2.9, EC:4.1.2.22 [1]. This family is distantly related to transketolases e.g. Pfam:PF02779.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.05	0.70	-5.91	6	1135	2012-10-02 16:07:47	2006-11-10 17:51:28	5	14	914	16	430	1562	249	358.00	48	46.75	CHANGED	hlo-ctLcplDtaWRAANYLulG.IYLp-NPLh...+EPLc.EclKpRLlGHWGTsPGloFlYAHlNRlIpKaDtsMlYlsGPGHGGPAhlusoYL-GoYoEhYPclopDcpGhp+LF+QFSFPGGIsSHhsPETPGSIHEGGELGYuLSHAYGAlhDNP-LIVsCVVGDGEAETGPLATSWHSNKFlNPtpDGAVLPILHLNGYKIuNPTlLuRIs--EL+shFcGhGYcPhaVpu....cDs.shH+hMApshDpsh--IpsIQ+sAR...sssps.RPcWPMllhRTPKGWTGPKa.......lDG..hhsEGoaRAHQVPLuss+cssupLp.LccWhcSY+PEELFDtsGslptslcshsPcG-KRMuuNPpANGGlLpcsL+lPDa+cYuls	...................................................................................................s..s.p.Lptlc...taWRAANYLol..............GQlYLh...c.NPLL...........+cPLp..-clK...s+l...l....GHWGT....s....PG.....NF...lYuHLN....Rl....I...p...c...h..s.......ls.....h..........ha.ltGPGHGGPuh.lu.ss.YL-Go.Yo.E.h.Y.P.c.lo.pDppGhp+LF+pF.....S.F.......P....G.G........l.s.....SHs.u.P.E..TPGSI..H..E..G..GEL....GYuLu....H....A.....a.....G....A.....s.....h.....D.....N.....P....D....L....l...sssllGDGE.AE.T.G.PL..A.sSWa.SNKF.lNP.h....pDG.AVLPILHLNGaKI..u.N..P.T..lL.u.Rho.c.-E.L.pphFcGhGacPh.a.V-G.............cD....tsh.Hpt...h.AtshDpslpcIptIQppAR.................p.s..s...s.s..+P..pWPMIlhRoPK...................GWTGP.+p.......lD.G..p.lEGsaRAHQVPlsss..p...p.s..pHh.chLpp.Wh+SY+P-.ELF....D.......p.......s.G...p....l..h..s-lt.t.....l.sP.p.G.p.p.R.MusNPhsNGG.h.lh....+sLphP.Da+caAl............................................................................	0	111	259	365
+9197	PF09365	DUF2461	CHP02453; 	Conserved hypothetical protein (DUF2461)	Bateman A	anon	PSI2 target BIG_248	Domain	Members of this family are widely (though sparsely) distributed bacterial proteins, about 230 residues in length. All members have a motif RxxRDxRFxxx[DN]KxxY. The function of this protein family is unknown.	20.80	20.80	21.40	21.20	20.20	18.40	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.21	0.70	-11.38	0.70	-4.94	99	698	2009-09-11 12:04:33	2006-11-14 14:11:37	5	3	644	0	255	606	173	203.20	28	84.13	CHANGED	sssshpFLpcLp..tNNsR-WFpspKspYcp.l+pshhshlspltspls.phcsph.s..h..psslaRIaRDl.RFS+DKoPYKsphusth.ptt.........pp....tsu...aYlclps.st..shluuGhap.....PpsptLpplRppIppsssp...hcpllpphphppha..............................t..s-pLKpsP..................+..Gasp..ccPhl-hL+pKsahshpphss.ptlhsschhcplsptapthtPhhca	................................................................t..pshpFLppLp..tsNs+pW...........Fpp............H+s................pY-p.lcpshpshlppltspht.phc.th.t.....tcs.laRIaRDs.RFS+D.KoPYKsphuuhh.pst...............tchs....tsuaYl...c..lpP..st......shlu.....sGhap.....sp.pstLtthRptItcpspt.......appll.pshphptha...................................................................hst-p..LK..psP.....................................................+..Gast..-hshl-hL+pKsassht.phss...chl.h.s.s.c.hhppltchapthpPhhca.......................................	0	79	170	223
+9198	PF09366	DUF1997		Protein of unknown function (DUF1997)	Bateman A	anon	PSI2 target BIG_266	Family	This family of proteins are functionally uncharacterised.	20.80	20.80	21.60	21.10	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.79	0.71	-4.48	34	280	2009-01-15 18:05:59	2006-11-14 15:55:48	5	4	121	0	159	288	167	151.10	21	67.50	CHANGED	sp.........tls.cYLpp.pRhhpshh.cshclptLsc.....spa+h..........pltshphhth.plpPslslclhspsss..............h.hp..shclcGlshl.......scaslshcupl..........................tsppstLpucscLsVslph.PthlphlPcsllcuoGcp...............................................lLptlltplppRlsppLhpD....appahtt	.................................................................................................t...lt.cYLpp.tphhpthh..cs..p....hpt...ls.c...........ppach.................................phh.hth.hth.plpPhlslplhspsps.......................h.hp..ph..cl.cG..hsh.......sppas.l..s..hpuplh..p........................................tsstsplpsch.clsV.slpl.P.slphlPp..sllcssGst...............................................lLppllpphpt+hhppl.pDappah..t.......................................................................................	0	37	94	136
+9199	PF09367	CpeS		CpeS-like protein	Bateman A	anon	PSI2 target BIG_280	Domain	This family, that includes CpeS proteins, is functionally uncharacterised.	20.60	20.60	20.80	21.60	20.20	19.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.92	0.71	-4.36	66	209	2009-01-15 18:05:59	2006-11-14 16:11:35	5	3	80	1	90	233	201	158.60	29	89.90	CHANGED	shtpFhppStGcWhSpRosHpL...sh..pcs..EsspSplslp..lssscsplhpls...p..tlsss.thhsuhthpWpup.phpp...pspsssslhhhlP..ts..ppGtLLRstGYsEphss...supaphssDs.sLsLpTcYsss.hspERlWFsssslR.hRsSslpphsGhs.......pso.FsoElRp	....................hhpFhptStGpWhSpRosHpLsh....pcs....EpspSplhlc..Lsssssplhpls...p.hplsss...thhsGhplpWpup.thsp...psppusslhshlP..ps....ppGhLLRspGYs.Ephss.......supYphsp-s.sLsLpTcYpph.hstERhWFsssslR.hRsShlpphsG.s........hsoFsoEhRh......................................	1	11	50	81
+9200	PF09368	Sas10	Sas10_Utp3_C;	Sas10 C-terminal domain	Bateman A	anon	Bateman A	Domain	Sas10 is an Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in the production of the 18S rRNA and assembly of the small ribosomal subunit.	25.00	25.00	26.60	26.60	23.70	22.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.58	0.72	-3.81	35	308	2009-01-15 18:05:59	2006-11-15 10:51:18	5	4	279	0	228	307	3	76.10	46	13.75	CHANGED	hssDuKRtIohpItKN+GLT.+R.pKcp+NPRVKpRtKYcKuhp+h+ophpsh+....pppus...YuGEhoGI+ssls+SlKl	....h.ttsuKRuIoYpItKNKGLTP+R.pKcsRNPRVK+RcKac+App+h+ut.hpsh+.......cppss...YuGEhoGI+sslsKSlKL......	0	82	128	188
+9201	PF09369	DUF1998		Domain of unknown function (DUF1998)	Bateman A	anon	PSI2 target BIG_296	Family	This family of proteins are functionally uncharacterised. They are mainly found in helicase proteins so could be RNA binding. This family includes a probable zinc binding motif at its C-terminus.	24.20	24.20	24.20	24.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.22	0.72	-3.41	165	1448	2009-01-15 18:05:59	2006-11-15 11:31:00	5	16	1110	0	569	1299	129	85.60	28	7.75	CHANGED	uhpHALhpthsh..hhthsps-l.shshh.t.........t.ttsslhlYDuhsG..GsGhsppl.....hct..htcllppAhchlpt..........................C..s..C...............p..sGC.sCl	..............................................................shpaAlhthlsh....hh.tss.ps.......-l..shsshhps.........................sthsslhlYDuhsG...GsGhsp.ph........hct.....htcllptuhchlpp...........................C....s...........C..............................................p..sGCssCl................	0	196	395	515
+9202	PF09370	TIM-br_sig_trns		TIM-barrel signal transduction protein	Bateman A	anon	PSI2 target BIG_293	Domain	This domain is likely to have a TIM barrel fold related to IGPS. Although this family of proteins are functionally uncharacterised this domain is found as an N-terminal domain of sigma 54 -dependent transcriptional activators (enhancer-binding proteins) suggesting a potential role in signal recognition/receiving and signal transduction.	25.10	25.10	25.20	26.00	24.70	25.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.60	0.70	-5.33	20	371	2012-10-03 05:58:16	2006-11-15 17:30:52	5	9	289	6	140	329	41	255.50	56	79.87	CHANGED	pplL.cphRpplppG.pPIlG............uGAGoGLSAKstEtGGlDLIlIYNSGRaRMAGRGSLAGLLPYGNAN-IVl-MA.pEVLPVV+c.TPVLAGVsGTDPFpsh-pFLscLKshGFuGVQNF.PTVGLI..DGpFRtNLEETGMGYshEVEMI+tA+phsLLTTPYVFssc-ActMs.cAGADIIVsHMGLTTGGsIG....AcTuhoL--sVphlsslscAA+slssDlIVLCHGGPIApP-DApalLc+sss.scGFYGASSMERLPsEtAIpppsppFKsl	...................t.plLp+h+ppItcG.cPIlG..................uGAGTGlSAKstEAGGhDLIlIYNSGRaRMAGRGSLAGLLsY.GsANpIVl.-MA..pEVLPVVKp.TPVLAGVsGTDPF.p..ph-tFLcpL+shGFuGVQNF.PTVG.....LI..D..GsFRtNLEETGMGYsLEV-MI+hAHchsLLTTPYVF.ss--AhsMs.cAGADIlVsHhGLTTuGsIG....A.c...T..A.....h.oL--sVthlpphtcAA.cpV.psDl..IVLCH.GGPIupP-DApYllcpstt.scGFaGASSMERLPsEtAlpppscpFKsl.........................................	0	40	93	117
+9203	PF09371	Tex_N		Tex-like protein N-terminal domain	Bateman A	anon	PSI2 target BIG_312	Domain	This presumed domain is found at the N-terminus of Swiss:Q45388. This protein defines a novel family of prokaryotic transcriptional accessory factors [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.09	0.71	-4.98	145	3396	2009-01-15 18:05:59	2006-11-15 18:19:14	5	18	3331	3	724	2645	145	190.50	46	25.65	CHANGED	lApELs.lpspQVpuslpLLDEGsTVPFIARYRKEhTGuLD-sQlRplp-RhpYL+cL-cR+pslLcuIcEQGKLTsE...LcppIpsApshscLEDLYLPYK..KRRT+ApIA+EtGLEPLAchlhspspt.....ssp.ptAtpal.....st-.......tt....VssscpALpGA+...cIlAEphuEcAclRpplR..phhhcpGh.lpo.pl..hpsccc-s	........................................................................................................................IupELs.hp.pQlpuslp.L.L.-.E.GsTVPFIARYRKEhTGu....LD-sQlRplc-R................hpYL.+pL--R+pslLc..sIp...EQ......GK......L...Tc.E...Lcpt.ItsupshscLEDLYLPYK.....K.RRT+ApIA+.........E..tG....LEPLA-h.lhspspp.................ss-..ppAtpal.................st-................t...........Vs..sscsALcGA+......pILsEphuE-AsLhsplR..phhh.c.p.u..h.lsSpl..hcscccE.s....................................	0	230	452	608
+9204	PF09372	PRANC		PRANC domain	Bateman A	anon	PSI2 target BIG_313	Domain	This presumed domain is found at the C-terminus of a variety of Pox virus proteins. The PRANC (Pox proteins Repeats of ANkyrin - C terminal) domain is also found on its own in some proteins. The function of this domain is unknown, but it appears to be related to the F-box domain and may play a similar role.	23.40	23.40	23.50	23.50	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.37	0.72	-4.02	77	463	2012-10-02 00:56:31	2006-11-16 17:40:10	5	59	47	0	6	429	0	93.10	24	17.31	CHANGED	hssho..laDllhspsp...phhh+hlps.phhph........ph..lYtphlcchIppuhpRpphlppslphlsshhpp......shWshLPhEI+hpIlphLssp-Lphlhp	...................tsholasllhspsp.....phhhRY.hps..p.hhph........h....sh.plYsshlcphltphhp+pphlsp.llcplpss.............shhopLP.EIphpIlphls..-Ltph..h...................................	1	0	6	6
+9205	PF09373	PMBR		Pseudomurein-binding repeat	Steenbakkers P, Bateman A	anon	Pfam-B_12784 (Release 21.0)	Repeat	Methanothermobacter thermautotrophicus is a methanogenic Gram-positive microorganism with a cell wall consisting of pseudomurein. This repeat specifically binds to pseudomurein. This repeat is found at the N terminus of PeiW and PeiP which are pseudomurein binding phage proteins.	24.90	24.90	25.10	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.08	0.73	-7.34	0.73	-3.77	49	106	2009-01-15 18:05:59	2006-11-27 14:56:45	5	26	19	0	90	104	9	32.50	28	8.87	CHANGED	sssplohpphhchss+lhsa.hpppsRh..Pshlsl	..t..splshsphlchssRlhsF.hppssRh..PsYls.....	0	37	67	76
+9206	PF09374	PG_binding_3		Predicted Peptidoglycan domain	Moxon SJ, Bateman A	anon	Pfam-B_8737 (release 8.0)	Domain	This family contains a potential peptidoglycan binding domain.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.46	0.72	-3.99	20	823	2012-10-01 23:43:47	2006-11-30 10:00:54	5	12	535	9	152	611	209	75.60	34	37.79	CHANGED	pAs+hLQ+hL......u.....ltsDGhIGspTlsAl........ssts.ssLhpthssuRhpaYhcLs.......................stspFscGWhsRls	...........................ss+hLQRhL..............u........l.tsDGhIGspTL...uAl..................sppu.tt.sL.lp.sLs...stptpa.Yhpluttp....................spppF.hhGWlpch....................	0	30	90	125
+9207	PF09375	Peptidase_M75		Imelysin	Bateman A	anon	MEROPS	Family	The imelysin peptidase was first identified in Pseudomonas aeruginosa. The active site residues have not been identified. However, His201 and Glu204 are completely conserved in the family and occur in an HXXE motif that is also found in family M14.	21.10	21.10	21.10	21.10	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-12.04	0.70	-5.10	169	1931	2009-01-15 18:05:59	2006-11-30 11:01:45	5	5	1429	10	414	1465	252	267.80	27	74.43	CHANGED	shssY.....pshhps.spsLtsu...spshs..sssst...............ssLptA..+sAahsARhsappsEshph.................s.h...........................t.tlthWP..sc...........uhl-hshssh...............................t..hssp.ht................sssspGaHAlEalLasps.......................s.t....t..sth.................................sphlp..uhustLhscsppltspWpt.........tshttth.....................t.tt.......ulp..pll...sGhssh.ls-lusp+.ls...sh..............ps.ptcspaScsohtshhs.slpGhpsla.s.............sulps.ll....tpp.ss..s....Lssplcsphss......shstlstl.ps.........shs..................ptl...ssspspth...........lps.h....suLsp.t.spl	......................................................hhssY.csalps.sppLhps.....scsFs......puh...ps.................sclppAKsha.hssRhhYpchEsltt..........................................................th.......uplDhplcup....................................tssh.pt.c.h...........................ssshoGaHtlEhhLasps.......................s................................................................sphhcthAspLhsDspcLppphssht..................h................................................................................ssp.phl....sGtssL..lpElAssK.ls...............................sEE-h...a.S..c.osLhD.apA.NlcGspp..lh.................................shlcs...h...l.......ppp..s.......p....LssclpspFppspshLsph..ps...............p.t......................ppl.......sssstpth...........hss..l...suLsc.hut..............................................................................................................	1	114	235	339
+9208	PF09376	NurA		NurA domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This family includes NurA a nuclease exhibiting both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA from the hyperthermophilic archaeon Sulfolobus acidocaldarius [2].	20.60	20.60	20.70	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.39	0.70	-4.89	65	438	2012-10-03 01:22:09	2006-12-01 16:54:16	5	2	287	10	251	429	41	278.20	14	74.78	CHANGED	tplhAlDGS............phth.phpsshhhhlhuhuhsstthtphthhthh.th.hh...............................................................cpthphhhthhEht...............................hhtttppsclllhDGslhtphh........................................................................................................................................h...thtchltth.phlct..........hsllulsKshpspplhsth..........................................................h.Dttllpthh.p.................s.pt.h.............................................hhhtthhtshp.hhhhYlph........ttss.lh+lE........h...................spstcllstlt...............................................hsspGYPhs...LthAcchu+l	...................................................................................................................................................................................h.phhulDGS............pht...h..phtths..hhhhhs....hu.h..h.s.ht.ht..p.h.thh..h...h.shh....h..h...t............................................................................................................pphhp.h.hthhEht......................................................hh..t.t.t.pp.ss.lllhDGsL.hhhhh........................................................................................................................................h...tht.ph.lt....h..phlcp.............th.llu.llKpsps..p...p.hhphh................................................................................h..tDh.t.lht....thh.p..............................................ss.pt.....h.h...................................................................................................hhthhtphp...lhhhYlph.......................sstlh+lE........h....h............................................tp.pchlshlh..............................................hhp.st.G....aPhs...LthAcp.sph..........................................................................................................................	1	91	160	213
+9209	PF09377	SBDS_C		SBDS protein C-terminal domain	Bateman A	anon	Bateman A	Domain	This family is highly conserved in species ranging from archaea to vertebrates and plants. The family contains several Shwachman-Bodian-Diamond syndrome (SBDS) proteins from both mouse and humans. Shwachman-Diamond syndrome is an autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, haematological dysfunction and skeletal abnormalities.  Members of this family play a role in RNA metabolism [2] [3].	21.20	21.20	22.80	21.20	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.38	0.71	-4.43	27	515	2012-10-02 20:07:24	2006-12-06 09:57:19	5	6	468	6	343	502	98	134.40	28	49.03	CHANGED	phhp-IssIlup+slsPpTp+sassshIE+Ah.c-lphu..............................................lsss+oAKpQAL-lIKtLpc..hlPItRAcM+l+lshssctspthh...........................................................ctltshhp.ph..tpp-ptsstaphlshlpPsta+tlpphlppp	..............hh+-llslluppslNPp.T.c+Passsh..IE+Ah.c-l.+hs..................................................................................lcssKssK.pQAL-slKtLpp....h.lPIcRAcM+lclplPs.ph..s.p.p..hh...............................................................................................................................................................................................ppltphhp...hh........cppt....t.s.s..phph.......l.shlsPGhhcpl.-hlp...................................................................................	1	114	198	282
+9210	PF09378	HAS-barrel		HAS barrel domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	The HAS barrel is named after HerA-ATP Synthase. In ATP synthases, this domain is implicated in the assembly of the catalytic toroid and docking of accessory subunits, such as the subunit of the ATP synthase complex. Similar roles in docking of the functional partner, the NurA nuclease, and assembly of the HerA toroid complex appear likely for the HAS-barrel of the HerA family [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.93	0.72	-4.08	60	266	2012-10-02 13:55:04	2006-12-06 11:10:15	5	8	209	12	130	3149	1869	90.80	17	19.30	CHANGED	lGhllGssst.pshhhhlps.t...............plphG-hVphp.t................tppllGhlhslpp.................................s.hshlshs..........................clluplcp	..................lG.Vlussss.pththhhcs.................tsphGcaVhlptp................sspllGhlpslpp...............h.p..t...t.......t..sp.hthltht............................h.....h.........................................................................	0	46	82	110
+9211	PF09379	FERM_N		FERM N-terminal domain 	Bateman A	anon	Bateman A	Domain	This domain is the N-terminal ubiquitin-like structural domain of the FERM domain.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.55	0.72	-3.93	30	3027	2012-10-03 10:59:06	2006-12-08 09:24:46	5	150	200	46	1524	2604	2	84.60	27	9.05	CHANGED	Vp.hLDss.hhphp.....lsspsp.GpplL-pVsp+l.slpEp-aFGLpa.....sps......sph...................................pWL-hs+plp+phsc...............ssshhlhFRlKFas	.......................................lhhh.Dsp......h..pht..............lp..tpsp.GppLh-..t....Vsp..+l......sL..h..E..p-.............YFGLta............cpp...................spt....................................................................................................................................pWL.-.sK.pl.p.cQ.hhp........................................................ssh.p.h..hF..plKFas................................................................................................	0	372	505	936
+9212	PF09380	FERM_C		FERM C-terminal PH-like domain	Bateman A	anon	Pfam-B_851 (release 2.1)	Domain	\N	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.03	0.72	-3.77	62	2452	2012-10-04 00:02:25	2006-12-08 13:07:32	5	88	124	42	1204	2086	0	90.40	28	10.92	CHANGED	cpcssc..lh.LGlsstGlhla...csss+l...ptFsWscIp+lSFccK.................................................+Fhlcht............................................tppppphsFhhss..hcssK..tlW+hClppHp.......F..a...phpcpsps	.........................................................................................................................pcGsc..lhLGlsstGlhla................csp.p...+l.....tt..FsW.scIt..+l.Sa.cc.+.................................................pFhIc.lhs..................................................................pppp.ss.hsFhhss......hcssK..plW+hClppHs.......F..aphtp...........................................................	0	270	364	720
+9213	PF09381	Porin_OmpG		Outer membrane protein G (OmpG)	Mistry J	anon	pdb_2f1c	Family	Porins are channel proteins in the outer membrane of gram negative bacteria which mediate the uptake of molecules required for growth and survival.  Escherichia coli OmpG forms a 14 stranded beta-barrel and in contrast to most porins, appears to function as a monomer [1].  The central pore of OmpG is wider than other E. coli porins and it is speculated that it may form a non-specific channel for the transport of larger oligosaccharides [1].	25.00	25.00	46.20	45.70	21.90	19.60	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.21	0.70	-5.33	4	299	2012-10-03 17:14:37	2006-12-08 14:43:39	5	1	282	10	9	87	0	288.50	92	99.37	CHANGED	MKKLL.CTALVMCAGMACAQAEEKNDWHFNIGAMYEIENVEGYGEDMDGLAEPSVYFNAANGPWRISLAYYQEGPVDYSAGKRGTWFDRPELEVHYQFLESDDFSFGLTGGFRNYGYHYVDEPGKDTANMQRWKIAPDWDVKLTDDLRFNGWLSMYKFANDLNTTGYADTRVETETGLQYTFNETVALRVNYYLERGFNMDDSRNNGEFSTQEIRAYLPLTLGNHSVTPYTRIGLDRWSNWDWQDDIEREGHDFNRVGLFYGYDFQNGLSVSLEYAFEWQDHDEGDSDKFHYAGVGVNYSF	.................................MKKLLPCTALVMCAGMACAQAEE+.NDWHFNIGAMYEIENVEGYGEDMDGLAEPSV......YFNAANGPWRIuLAYYQ...E...G.P.VDYSAG.KRGTWFDRPELEVHYQFLEsDDFSFGLTGGFRNYGYH.YVDEPG..KD..TA...NMQRWKIAPDWDVKLTDDLRFNGWLSMYKFANDLNTTGYADTRVETETGLQYTFNETVALRVNYYLERGFNMDDSRNNGEFSTQEIRAYLPL.....TL.....G.N.H...SVTPYTRIGLDR.WSNWDWQDD.IEREGHDF.NRVGLFYGYDFQNGLSVSLEYAFEWQD.H.....DE...GDS..D.....KFHYAGVGVNYSF..............................	0	1	3	5
+9214	PF09382	RQC		RQC domain	Bateman A	anon	Pfam-B_571 (release 21.0)	Domain	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure.  The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.18	0.72	-4.32	174	3296	2012-10-04 14:01:12	2006-12-11 14:34:43	5	41	2926	9	924	2638	355	104.30	30	14.90	CHANGED	DsTptApclLSslh+h..........t..p....p..........a..Ghshlh-lLp.........................Gspsp+ltph....sa.cplssa..GlGc.chsppphpsllcpLlspGhL.....phshp......pas.sLplspp.u..cslLc..Gc....p..plhlphst	................................................DsTpcAppsLSslhRs.................sp.........+.........FGhshll-V.L+.........................G..s..p.s.p..+lpph.....sa..-p..L.ssaGlG.......+..-.....h...op..cc........hpsll+pLltt.Ghl.........p.shs.......pas..sLpL..Tct..u..+slL+.Gct..pl.ht...s.....................................	0	278	557	764
+9215	PF09383	NIL		NIL domain	Bateman A	anon	Pfam-B_524 (release 21.0)	Domain	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins. This domain is likely to act as a substrate binding domain. The domain has been named after a conserved sequence in some members of the family.	20.60	20.60	20.60	20.70	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.05	0.72	-4.41	184	4317	2009-01-15 18:05:59	2006-12-11 17:17:47	5	25	3162	22	702	2638	28	75.40	25	22.67	CHANGED	sstll+LpFsGpssppPllupls+ca....s.lssNILtGsl-plpstshGpLllpl......t..Gsppp..hppulpaLp.pps.lpl.Ell	...............................s...ll+LpFsG.p.s.ssp.Pllupls+ca....s.lssNILtusl-hlp.s..sshGtLllpl................................p..Gsppp..hptAlpaLp.pp.t.Vpl.Ell......................	0	181	399	562
+9216	PF09384	UTP15_C	U3_snoRNA_C;	UTP15 C terminal	Mistry J, Wood V	anon	Pfam-B_7112 (release 21.0)	Family	U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA [1]. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs) [2]. This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (Pfam:PF00400).	26.90	26.90	27.40	27.60	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.45	0.71	-4.51	40	321	2009-09-21 22:48:38	2006-12-12 09:50:17	5	11	278	0	219	324	1	147.80	28	28.41	CHANGED	+Gps...hhscp--hllppt..........ppp+lppa-+hLppF+aucALDssL.........tstpscsslollpELp+RG......sL+tALtsRDEtoLpslLpalh+pls-sRassllhcssssllDlYusslspSs..hlcchltpLpp+lpcElchppchhplpGMl-...hL	..................................t.phhspts-hl.lspt..........pcp+lp...ta-+tL+pF+........aucALDpsL................tspssphslollpELt+Ru......sL+sALsuRDEpsLpslL.palh.+pl.s..c...PRassllhsluthllD........l..Y..u..sh.l...sp.Ss.......hlcchh.hpLppplpcElchppphhphtGhl-hl...................................................................	0	77	122	179
+9217	PF09385	HisK_N		Histidine kinase N terminal	Mistry J	anon	pdb_1yku	Domain	This domain is found at the N terminal of sensor histidine kinase proteins.	24.40	24.40	24.90	26.60	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.62	0.71	-4.55	7	130	2009-01-15 18:05:59	2006-12-12 10:37:03	5	3	103	3	13	66	0	137.40	58	43.26	CHANGED	Mp...........sspphLssaLcpppcpFlpsW+p+llls-cD.a+-cllpNGptlhchhhphhpcphs.p...lp.lupKIApERh-AcsNIu-FVYNsNhGRpElhphlstlssshp-LpsllccINhhFD+hlYasVppYs-	..............................................MtVFPIDK..DIKElFCSHLKNNRHQFVENWKNKM.....IIS-KDPFK.EVVQNGEcLLEhIIELhME-KDIs..YLQPLCEKIAIERAGADANIGDFVYNANVGRNELFEAMC.....ELDVSAR..ELKPIM...spIHTCFDKLIYYTVLKYSE....	0	1	7	9
+9218	PF09386	ParD		Antitoxin ParD	Mistry J, Bateman A	anon	pdb_2an7	Domain	ParD is a plasmid anti-toxin than forms a ribbon-helix-helix DNA binding structure [1].  It stabilises plasmids by inhibiting ParE toxicity in cells that express ParD and ParE.  ParD forms a dimer and also regulates its own promoter (parDE).	22.80	22.80	23.30	23.50	22.30	22.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.65	0.72	-3.86	4	38	2012-10-02 18:44:02	2006-12-12 14:31:42	5	1	37	2	7	32	2	77.80	61	92.81	CHANGED	MSRLTIDITDQQHQSLKALAALQGKTIKQYALERLFPsDsDuDQAWQ-LKsLLGsRIu-GLAGKVSsKSlsEILsEELu	..MSRLTIDlT-QQHQSLKALAALQGKTIKQYALERLF...P..uDuDuDQAWpEL+sLLssRIppGLsGcVSsKSlscILDEELs.........................	0	1	6	6
+9219	PF09387	MRP		Mitochondrial RNA binding protein MRP	Mistry J	anon	pdb_2gid	Family	MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex.  The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilises them in an unfolded conformation suitable for RNA-RNA hybridisation.  Each MRP subunit adopts a 'whirly' transcription factor fold [1].	18.60	18.60	18.80	18.80	18.50	18.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.31	0.71	-4.58	11	164	2009-01-15 18:05:59	2006-12-12 15:52:17	5	4	50	14	43	134	1	157.00	29	36.07	CHANGED	suts.u-usustustusssuo....+ppssusppt.Rs...PAF-IsHhsc-csupGs.atlsVst+sshl.p.PsLD.+..Rp.pplDp.............Ncss.Qscu-R.sloVphpslasAphluVLcuRhsplcspsphhsAsFsPsspsYshctpl+psuop................psh-W.....oVcF-sthulhLc+FLppAL+.shGFucphs	.......................................................................tst...ttts.....t...t..p..........t.hpl.+.stps.s.u.........t...s......htt.h..........Ls.p......tss........................s....t.pu-h...h...h.t........ssa.sp.sthlptRhshhps.s....h.......ssphY.hctp.+...tst...................................................................................................sth.W.....hhphss.hhuhh..hhLppsL...........h...................................................................................	0	6	9	19
+9220	PF09388	SpoOE-like		Spo0E like sporulation regulatory protein	Mistry J	anon	pdb_2c0s	Family	Spore formation is an extreme response to starvation and can also be a component of disease transmission.  Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A.  Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation.  This is a family of Spo0E-like phosphatases.  The structure of a Bacillus anthracis member of this family has revealed an anti-parallel alpha-helical structure [1].	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.94	0.72	-4.44	47	988	2009-01-15 18:05:59	2006-12-12 16:44:01	5	4	287	3	195	665	0	44.70	32	66.69	CHANGED	pLhppIEp+Rcchlplstph.GlsspcslphSQELDpLlNpYp+hp	.............................LpppIEtpRccLh...p.l..s...pch...Gh..s.pp.cllphSQELDcLlNpa.ph.h............	0	68	144	154
+9222	PF09390	DUF1999		Protein of unknown function (DUF1999)	Mistry J	anon	pdb_2d4o	Family	This family contains a putative Fe-S binding reductase (Swiss:Q72J89) whose structure adopts an alpha and beta fold.	25.00	25.00	85.50	85.30	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.94	0.71	-4.88	3	18	2012-10-02 22:59:21	2006-12-13 11:24:32	5	1	18	2	12	18	1	148.80	53	97.85	CHANGED	M...RYRsFoEPDaEsLQALDLAtQRRssPtaDsLP-REpAGRLSoSLuALRFYERSGHSFVAEsEu-clpGalLAQuVWQGDRPsVLVRAllLs-upsEDstRGLLRAVVKSAYDAAVYEVHLPLsP...ELEAAARAEEA+LTG.sYAVpHLGTRAAoAPG++LtR	...............................M+aRsFsE.Dh-tLptL....................tGchssSLuALRFFsRTGHSFlAp.EG-cshGFsLAQAVWQG-tsTVLVsRl...-ups....t....-shcGLLRAVVKSAYDAGVYEVALpL-Pt.+t-LcpALcA-Gas.lushsLAVRVLGSRGtRuEsctVL.E.	0	3	7	12
+9223	PF09391	DUF2000		Protein of unknown function (DUF2000)	Mistry J	anon	pdb_2gax	Family	This is a family of proteins of unknown function. The structure of one of the proteins in this family has been shown to adopt an alpha beta fold.	25.00	25.00	26.20	30.30	20.70	17.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.37	0.71	-4.49	36	322	2012-10-02 19:40:38	2006-12-13 13:31:01	5	2	297	2	106	309	39	130.80	30	94.96	CHANGED	-sKhslllcc-LsshptLNVsAaLusGlus..stP-hlGpsYtDusGphahslht.PlllLpu.spspLppl+pculp+...slshssaopshhsTGpppspptshttsst--lchlGlALhGs+KhVcKlT+uhsLat	............pKhslllcpcLssh.thNssAhLuhulut........phP-llGp..s.htDusGpta.slht.Pl.lLpu.stptLppl+pcuhsp....slhhssFspth.ssss.pp.ptshtssstsslphlGlulhGs+KtVsKlstuhsLa........................	0	25	52	81
+9224	PF09392	MxiH		Type III secretion needle MxiH like	Mistry J	anon	pdb_2ca5	Family	Type III secretion systems are essential virulence determinants for many gram-negative bacterial pathogens.  MxiH is an extracellular alpha helical needle that is required for translocation of effector proteins into host cells [1].  Once inside, the effector proteins subvert normal cell function to aid infection.	27.40	27.40	27.60	27.90	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.90	0.72	-3.42	39	1127	2009-01-15 18:05:59	2006-12-13 14:16:18	5	1	510	43	74	367	1	79.00	20	87.18	CHANGED	lsthspthpssssst...............................................tpplppthpshptt...................................................ssP...pplhphQtplspaolhhslpopslpthppslpsll.ph	.............................................................hh..................................................................tlpt..tthtpts.......h......................................................................st.hs...s...P.....ptlhphQhsltpaolhhshpSsls+thpshlssll.p.h.......	0	17	35	50
+9225	PF09393	DUF2001		Protein of unknown function (DUF2001)	Mistry J	anon	pdb_2guj	Domain	This family includes phage-like element PBSX protein (Swiss:P54332) whose structure adopts a beta barrel flanked with alpha helical regions.	22.40	22.40	22.40	23.30	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.42	0.71	-4.48	25	231	2012-10-01 22:58:23	2006-12-13 17:06:55	5	1	162	2	56	189	2	140.60	30	95.64	CHANGED	M......hcupcsIsGphGclal....cspphspspphpAclchsKp-lshhGcphsppKssGhcGoGolThY+VoShhhphhhchlKpGp-shFclhspLcDPsS.hGt..EclsLcssshDclslAsa-ss..-hlEEEsPFTF--a-ll-	..................................hhcupcslsGp.Gchal.....cspphtphpphEAclEhsKp-lplhGc.hhpspKs..sGhpGoGohThap.loShhtph.hhch.l..+p.G.....p.-.hF.sl.ssh-DPso...hGp...cplhLpsss.hD...s...hhlush-ss..-hlE.EEhsFTFpca-h.-.................................	0	24	47	50
+9226	PF09394	Inhibitor_I42	Chagasin_I42;	Chagasin family peptidase inhibitor I42	Mistry J, Bateman A	anon	2fo8	Domain	Chagasin is a cysteine peptidase inhibitor [1] which forms a beta barrel structure [2].	22.30	22.30	22.30	23.60	21.80	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.12	0.72	-3.65	103	354	2009-10-19 12:22:43	2006-12-13 17:26:24	5	19	270	16	162	332	18	92.20	23	51.54	CHANGED	lsl..phGp.phtlpLspNPo..TGYpWplpt........sshlpl..hss......pahss..t.ss......hlGuuGhph.aphpuhps....G....psplphhYtRsW-ssss...ppash.slpV	................plp.Gp.phhlpLsuNPo..........T.GYpWphps...........sssslph....hss....................pahss...s.ss.t........hlGu.u.Ghph.apapuhps.....G....psplphtYtRsW-ssst...pphshpl.l....................	0	55	103	136
+9228	PF09396	Thrombin_light		Thrombin light chain	Mistry J	anon	pdb_2b5t	Domain	Thrombin is an enzyme that cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII. Prothrombin is activated on the surface of a phospholipid membrane where factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. This domain corresponds to the light chain of thrombin.	20.60	20.60	20.80	22.20	19.50	18.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.62	0.72	-4.35	13	80	2009-01-15 18:05:59	2006-12-14 17:18:55	5	8	46	403	27	111	1	47.70	64	8.36	CHANGED	TshspacoFFss+TFGsGEADCGlRPLFEKKslpDpoE+ELL-SYhpGR	....Tsss-apsFFs.+TFGs....GEADCGLRPLFEKKslcD+oE+ELL-SYh-GR...	1	1	3	10
+9229	PF09397	Ftsk_gamma		Ftsk gamma domain	Mistry J	anon	pdb_2j5p	Domain	This domain directs oriented DNA translocation and forms a winged helix structure [1].  Mutated proteins with substitutions in the FtsK gamma DNA-recognition helix are impaired in DNA binding [1].	25.10	25.10	25.40	25.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.10	0.72	-4.26	130	5039	2012-10-04 14:01:12	2006-12-15 16:44:09	5	23	4114	16	987	4009	1919	66.30	43	7.56	CHANGED	ssp.ppDsLa--AlplVlcpppASsShlQR+hRIGYNRAARLl-pMEppGlVushpus.tsR-VLh....tp	..................s.tptDsLa-cAsph.Vl....c...p..p..+....ASsShlQR+h+IGYNRAARll-phEppGlVust.p.u.s.tsR-VLh..t..............	0	318	635	820
+9230	PF09398	FOP_dimer		FOP N terminal dimerisation domain	Mistry J	anon	pdb_2d68	Domain	Fibroblast growth factor receptor 1 (FGFR1) oncogene partner (FOP) is a centrosomal protein that is involved in anchoring microtubules to subcellular structures.  This domain includes a Lis-homology motif.  It forms an alpha helical bundle and is involved in dimerisation [1].	29.40	29.40	29.40	29.40	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.85	0.72	-3.99	6	189	2009-01-15 18:05:59	2006-12-18 11:26:16	5	6	93	2	120	199	3	75.50	35	27.53	CHANGED	K.oPLsNENLKKhlsT+-...GRLVAsLlpEFLpFFpLDFTlAVFpPEuuh.pshpsRpsLuK-LsIs-u-ssKssPLLhEll++	..................................p...shLlspLlpEaLpF.phcaThuVap....sEo..up..s.p.s...........s....Rp.Luc-Lslh-.....s..pt...s.ss..h..PLLhtllt.................................	0	50	60	86
+9231	PF09399	SARS_lipid_bind		SARS lipid binding protein	Mistry J	anon	pdb_2cme	Family	This is a family of proteins found in SARS coronavirus.  The protein has a novel fold which forms a dimeric tent-like beta structure with an amphipathic surface, and a central hydrophobic cavity that binds lipid molecules [1]. This cavity is likely to be involved in membrane attachment [1].	25.00	25.00	197.30	197.10	19.70	15.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.42	0.72	-3.95	4	60	2009-01-15 18:05:59	2006-12-18 11:57:56	5	1	59	8	0	23	0	97.70	94	100.00	CHANGED	MDP.KTNVVPPALHLVDPQIQLTITRMEDAVVHGQNNADPKVYPIILRLGSQLSLSMsRRNLDSLEARsFQSTPIVVcMTKLATTEELPDEFVVVTAK	MDPNQTNVVPPALHLVDPQIQLTITRMEDAMGQGQNSADPKVYPIILRLGSQLSLSMARRNLDSLEARAFQSTPIVVQMTKLATTEELPDEFVVVTAK	0	0	0	0
+9232	PF09400	DUF2002		Protein of unknown function (DUF2002)	Mistry J	anon	pdb_2g7j	Family	This is a family of putative cytoplasmic proteins.  The structure of these proteins form an antiparallel beta and sheet and contain some alpha helical regions.	19.70	19.70	20.40	26.20	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.49	0.72	-4.34	4	520	2009-01-15 18:05:59	2006-12-18 12:57:38	5	2	516	1	30	104	2	111.10	86	97.78	CHANGED	MYLRPDEVARVLEpsGFphDhVTscuYGYR+GEpYVYVNREARMGRTALlIHPsLK-+SssLApPsSsIKTss+Y.pFPLYLuG.thpE+YGIPHGFSSR.uLppaltphF.....c	.........................MYLRPDEVARVLEKVGFTVDVVTQKAYGYRRGENYVYVNREARMGRTALVIHPTLKERSSoL.....AEPASDIKTCDHYQQFPLYLAG..EpHEHYGIPHGFSSRlALERYLNGLF.GE...............	0	1	4	17
+9233	PF09401	NSP10		RNA synthesis protein NSP10	Mistry J	anon	pdb_2fyg	Family	Non-structural protein 10 (NSP10) is involved in RNA synthesis. it is synthesised as a polyprotein whose cleavage generates many non-structural proteins.  NSP10 contains two zinc binding motifs and forms two anti-parallel helices which are stacked against an irregular beta sheet [1].\	  A cluster of basic residues on the protein surface suggests a nucleic acid-binding function.	21.50	21.50	22.10	38.80	20.00	21.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.64	0.71	-4.39	11	653	2009-01-15 18:05:59	2006-12-18 16:29:24	5	34	206	53	0	662	0	121.00	53	2.47	CHANGED	ssNSslLolCuFuVDPupsYlDhVpsGupPlsNCVKMLss+oGsGhAITssP-AshsQ-oYGGASlClYCRsHl-HPshsGhC+hKGKaVQVPh.sspDPltFsLcNsVCsVCGhWhsaGCsCDt	....ssNSulLSlCAFAVDPAKsYhDalssGspPlsNCVKMLssHsGoGhAITssP-ushsQ-SaGGASsClYCRs.Hl-HP....s.hcGhCchKGKaVQlPo.stpDPVuFsLcNcVCsVCGhWhsaGCsCDt...	0	0	0	0
+9234	PF09402	MSC	MAN1_C;	Man1-Src1p-C-terminal domain	Mistry J	anon	pdb_2ch0	Domain	MAN1 is an integral protein of the inner nuclear membrane which binds to chromatin associated proteins and plays a role in nuclear organisation.  The C terminal nucleoplasmic region forms a DNA binding winged helix and binds to Smad [1]. This C-terminal tail is also found in S. cerevisiae and is thought to consist of three conserved helices followed by two downstream strands [2].	21.70	21.70	22.00	22.10	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	334	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.04	0.70	-5.73	37	386	2009-01-15 18:05:59	2006-12-20 11:29:55	5	12	255	1	248	363	1	257.20	21	43.10	CHANGED	hLlhshhlha.....shaatppphtlGaCupsh.st....................................................C..CP.puhCh...plpCctsahht...h..................sspCh.Dsc+tphlptl..hcthhchL+p+suphcC.G................t.psshssslsts-..........................ltchltppp....hhstppF-p.hapsslttlpcp....-lhhp.......................................................................spthhhusohsplslpC..thppplpphlh..........chthhlhslhlhhhsh...hhl+hthppcppcptplppllppslcpLppptt...........t.spsppsalslspLRDp.....lltsptphp........ppplWp+lhphl.-p.susVcsphtE.htG-hh+sWEWlssh	..............................................................................................................................................................................h.............................................................................................................................................................................................................................................h........ctpttthhptl...pphhphLtpptuphpC.G.............................t..p.tls.t-..........................htphltp.p..........tp...hpp.haptsl.t..lhpp...........t-lh.ht........................................................................t..s.sp.hhhhp.sshsphshtC..thpp.th...hthht...............phhhh..hhslhhh.h.hhh.......hhhc.hphp.pt....cppptth.p....hlppll...chLpsptt.................t.s..tt.psalslsplRDp.....ll.sp.pchp.........................................hpplWp+shphl..tt.poplpsp.pc..hsGc.hhsWcWhts.s........................................................................................	0	80	125	192
+9235	PF09403	FadA		Adhesion protein FadA	Mistry J	anon	pdb_2avr	Family	FadA (Fusobacterium adhesin A) is an adhesin which forms two alpha helices.	25.70	25.70	26.00	25.70	24.70	25.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.63	0.71	-4.12	3	115	2009-01-15 18:05:59	2006-12-20 11:44:49	5	2	30	9	12	93	0	119.50	35	97.25	CHANGED	MK.KhLLhuhLlLSuhSaAA--......AtpllSELKuL-AEYQsLspcEEARFpEEKppuEsAcppltcLcElpsulEE+lt+LpEEuKTRFaKDpYccLhK+Y--YLsKLEpKIs-pcplIS-FEKIQclR	...................................MK.K..hl..Lh..s.hLlluuhuaAAps...............stplhuE..lpsl-AEYQpLhpcEptRhpE.+ppt-...shcppltp.cph.tphpchht+Lpp-.uchRaa+..cpYpcLh.K+ac-hhpcLEpchtcpcphIsphpKl.tlh...............	0	6	11	12
+9236	PF09404	DUF2003		Eukaryotic protein of unknown function (DUF2003)	Mistry J	anon	manual	Family	This is a family of proteins of unknown function which adopt an alpha helical and beta sheet structure.	19.80	19.80	21.60	20.30	19.10	19.00	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.44	0.70	-6.07	3	98	2012-09-27 07:58:09	2006-12-20 14:16:26	5	7	69	1	71	99	0	328.40	41	81.61	CHANGED	MsDs...EELRPVP+ERAVLESFFTQLGMFSFDRAKDYVEKEKDASKSAGAIWuSLLAALAHLAAAEKlYHNMTFLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVoMGRsAPGGSAPsLEELLPHLSEQLCHFlQARMEIADFYEKMHoLGSQKoINSEELVoTLDoIL+KYSSRFHHPILSRLESSFQlEVDVLTQLLRCQAQISEW+FLPSLLoLHGAHSKLQoWGQlFERQRETRKHLFGGQSQKAVQPPHLFLWLQRLQAsLLAKFSFYFHEALSRQTosSEMKALTARTuPDYFGKISSFIRKYDASNVSLVFDNRGSESFQGHGYHHPHSYREAPKGVDQFPAVVSLPSGERPVTHWPNVIMIMoDRAoELNTLEKVVHFYDDKVQSTYFLoRPEPHFTIVVIFDGRKSERDSaIlAFLQELsGSLRNSKPFoSLKPGSKG	.............................................................................................................................hh.th..hs.hcp.Yhph.ah..c.....hht+.pp.o.hh...YpsLhsph...pph.t...................................t.......p......hhsplspQLs.FhpARh-hhshYcp.hhshu.sp..p..h..s.ccLlshL-slhcpasp+hpHs..hLp...lcsuhphElslLtpLL+sQsplscacFLs.oLlsLasA+.....s+Lp..sWs.p.h...h....p.pp..ppo..pK..phFuu..pspKs......sp....sP.pLahWL.+hpshLLuKFShYFH-sLSp...Q.....so......s....u..-.M.K.slsu+s....ss.Dhhs....+IpuFhRKhD.u..slsLla....Ds..+u.s....-.s..ap.upGYpaPpp..p-sPp.....G..l.cpaPslhohP.s...p.......p.Ph...HhPNllhl......ht-pt..s-Lss.h.-+llaahD....s.+.lps.................TY...alsps-sphhlV.lIac.s.p+.p-+DphhhsFlp-ls.tL+ssKhht.L+..........................	0	31	36	54
+9237	PF09405	Btz		CASC3/Barentsz eIF4AIII binding	Mistry J	anon	pdb_2jou	Domain	This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz).  CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa.  The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [1][2].	20.80	20.80	21.50	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.24	0.71	-4.10	21	266	2009-01-15 18:05:59	2006-12-21 09:49:36	5	7	179	10	185	259	0	121.40	24	19.09	CHANGED	sssssppsup.sst..tt...t..pptccp-pcchcc-ccpsPs..aVPsRGsFFhHDcRss-sssssh+................R.hu......................h...s.h..................t+phpssutpspWsHDha-phss-psPpsp.phhsthshshpspss	........................................................................tts................t..t..tp..........tttcct..t..p.c.ttpccccpsPt..alPp+GsFahHDc.Rtp.sst...p...th+....................pstG.......................................h........................................t+thpsss....t.ttpWpHDpacp...pc..ptsppptphht..t........tt..........................................................	0	52	87	143
+9238	PF09406	DUF2004		Protein of unknown function (DUF2004)	Mistry J	anon	pdb_2aby	Family	This is a family of proteins with unknown function.  The structure of one of the proteins in this family has revealed a novel alpha-beta fold [1].	22.40	22.40	22.90	24.00	21.20	20.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.17	0.72	-3.98	22	148	2009-09-10 18:54:03	2006-12-21 10:54:57	5	1	128	1	20	117	5	99.60	26	66.38	CHANGED	phpcpAcpAltshhpsc........ppahpaHl--httchh..hh...t...sshpphlctlpltths.a.p.tst....hhhhDathss-.hoD.llsVpFcppGclhp.lsaES	..................................p.htppA+pAlhp.hcp-........shYh-FHt--hspphh...h...........shpphlctl..pLttls.ahs..pst.pp.shs...hDaphss-..oDElLsV+acpcGclhp.lsaES...	1	7	14	17
+9239	PF09407	DUF2005		Protein of unknown function (DUF2005)	Mistry J	anon	pdb_1zel	Family	This is a family of proteins with unknown function.	25.00	25.00	56.60	32.70	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.10	0.70	-5.67	2	47	2009-01-15 18:05:59	2006-12-21 11:07:22	5	2	45	2	3	12	0	279.90	91	99.00	CHANGED	M....................VSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPL.RVIGKA	..............................hlSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEA...AISDPYLPLRSWLA.RDQNAGFMLAGA..SAAWHLGYLDRQPDG.RIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA.....................................	0	2	3	3
+9240	PF09408	Spike_rec_bind		Spike receptor binding domain	Mistry J	anon	pdb_2dd8	Domain	Spike is an envelope glycoprotein which aids viral entry into the host cell.  This domain corresponds is the immunogenic receptor binding domain of the protein which binds to angiotensin-converting enzyme 2 (ACE2) [1].	25.80	25.80	26.00	26.50	22.00	25.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.56	0.70	-4.83	11	626	2009-09-14 15:17:47	2006-12-21 12:06:25	5	3	218	29	0	442	0	166.60	48	21.86	CHANGED	PNLPD.CsIEcWLsApoVPSPLNWER+pFSNCNFNhSoLhpalQA-SFoCNNIDASKlYGhCFuSlolDKFAIPsSRplDLQlGsSGaLQohNYKIDTsuTSCQLYYSLPtsNVTls...NaNPSSW.............................NRRYGFNshshht......hspHDVVYuppCFssssoaCPCtpss.......hhusCls.........spssousC.PsGTphhpC.tthshsh..........tCcCsCsPcPhs	............................t.C.ht.hhss.....PpshsWcRhhhpsCshshs.lhp..h.htph.C.shs.s+l.s.Catsl.hD.Fhh.tt...........................................................t.h..........................................................s..........sh.psps........hGhhspHDVVYApcCFp.....APssaCPCKLsu.........u...hCVs.s......hppTGhGsC.PsGTsY..hsCapts.................sDslssPcshp...............................................................................................................	0	0	0	0
+9241	PF09409	PUB		PUB domain	Mistry J	anon	pdb_2cm0	Domain	The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain [1]. This domain is also found on other proteins linked to the ubiquitin-proteasome system.	20.30	20.30	20.30	20.30	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.79	0.72	-4.22	76	656	2009-01-15 18:05:59	2006-12-21 13:09:37	5	60	181	5	451	632	8	85.50	22	15.60	CHANGED	pshcphtpslphLh.cllpNIlppPsctKaRpl+hsNpshppplhsh.ps....uhplL.phhGFpppt.........pthhhhs...tts.......shttlpphhpt.......L	..............................t...tthtpuhphLh.phlsNll...p.....p..P......p..-......p...KaRpI+hsN.tsFppcltsl.pG......uh-hL.pthGFpct.................pphhhhs.....t..........p...........hh..........................................	2	189	262	372
+9243	PF09411	PagL		Lipid A 3-O-deacylase (PagL)	Mistry J	anon	pdb_2erv	Family	PagL is an outer membrane protein with lipid A 3-O-deacylase activity. It forms an 8 stranded beta barrel structure [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.81	0.71	-4.07	51	691	2012-10-03 17:14:37	2006-12-21 16:16:45	5	3	608	2	225	817	917	139.70	20	62.70	CHANGED	sssshpshplshpashsh.......phtttplphhh-sshshhp.....sst........ssth.hGhssh.hpaphss.t.....halEsGlGsthhspsphs......................t.phuotFpFpsplGhGhpassst......pluhRapHhSNAGlp.p.PNsGlsthslhhuhsF	..................................................................................................s......h.h.h.ht...........p..hhth.t..h..ch.shs.hhp......sst.............ts.h.hG..hs.h..hth.hhtt......hah..phG.hG.st...hhspspss......................thp..l.uos.a.p..F......tpp..hul..G..hpasst........psuhphpHhSNuul....p.p.sNsGhN.h.h.shpluhsa............................	0	59	132	186
+9244	PF09412	XendoU		Endoribonuclease XendoU	Mistry J	anon	pdb_2c1w	Family	This is a family of endoribonucleases involved in RNA biosynthesis which has been named XendoU in Xenopus laevis. XendoU is a U-specific metal dependent enzyme that produces products with a 2'-3' cyclic phosphate termini.	25.00	25.00	29.60	29.40	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.80	0.70	-5.35	40	279	2009-01-15 18:05:59	2006-12-22 09:55:27	5	13	125	3	203	282	1	246.00	34	69.40	CHANGED	stsss-lpslsppLWshD....sN+h.............sutca.plshQsptsshsp.....sDt.AspsLFshVs-shhp..pP....TautahsLlDNYphssG.....hsE.plTsp..EppEppsFL-tlh.pTslM+hhapaLhpKsh.......ssss.psF+.phLpplWFphYsRssut......h-.SSGFEHVFVGEhK.s..........sclpGhHNWlpFYlpE..+pGp......lDYpGYhhctpts...s........lLslQFpWs..........ul.hKsluShFlGsSPEFElALYTlCFlsssc......cp.splplus..hplsIhs..aphtpps.......IGouYP	...........................................tp-lpplsppLaphD.....Nph.................tpph.hlshQsphps..tp......tDt.usps.LFshVspphhp..ps....TatthhsLhcN..Yphs.su.....hsE..hho.sp..chpEpssFLctlh.pTslM+......hapaLhpKsh.......h.ss.p.pF+.p.Lppl.WFshYuRspsp.......s.SSGFEHVFl.GEhK..s..............scl...GhHNWlpFYhpE.......cpGp......lDYhGahhctphsp..sp..........llslpFsWp...........uh.hK.luo..hFlGsSPEFEhALYTlCFlspsp........ct..spl..plss.....h.htlhsaphttpt.......Iuoua...................................	0	77	101	166
+9245	PF09413	DUF2007		Domain of unknown function (DUF2007)	Mistry J, Bateman A	anon	pdb_2hfv	Domain	This is a family of proteins with unknown function.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-9.00	0.72	-4.15	90	1038	2012-10-01 21:59:08	2006-12-22 11:53:11	5	11	859	1	319	859	252	65.90	22	55.22	CHANGED	hclhpsss....lpsphlpslLcpsGItshlpspt.huuh.........s...us.sh..hclhVtc.cDhccAppllpchpt	..................h..lhpsss....hcAphlpslLcspGItshl..p....spt.hssh...........h.....ss.uh.....hclhVt-.cchppAppllpph..t.................	0	106	212	273
+9246	PF09414	RNA_ligase		RNA ligase	Mistry J, Coggill P	anon	pdb_2hvq	Family	This is a family of RNA ligases. The enzyme repairs RNA strand breaks in nicked DNA:RNA and RNA:RNA but not in DNA:DNA duplexes.	20.90	20.90	21.00	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.53	0.71	-4.50	22	428	2012-10-02 00:43:09	2006-12-22 12:03:17	5	5	363	7	118	450	40	184.40	19	55.28	CHANGED	p-aVsoEKlHGsshslhh.tttp.........hphstpos.............thp..................hhstatpslpshphhhc..ht..h.......stslhlhGElhG.............Pslpttsh....................t......chcFasFclhh....tp.t......phhs.cthpthspphslt....hsPhLscGshsthhhhss......................................................................h..shtt.slsEGlVl+sst...........ststshlKh+	.........................................................hlhpEKlDGsNhs.l.hh..t....................hthhtRsp.........................ht.....................................................................tpsta...ttt.hpthhthhp...t...................htshhla.GEhhhhh.................pul.phpth..........................................................................cpcFa.lFslhsp.......stt.........taLs.h-..ps.phhsphhs...l......h....VP...h..lh...ts.t.h..s....h.tthph..thh......................................h..shts.sh.t..EGlVh+stt........t.........h......................................................................................................	2	55	89	107
+9247	PF09415	CENP-X	DUF2008;	CENP-S associating Centromere protein X	Mistry J, Wood V	anon	manual	Family	The centromere, essential for faithful chromosome segregation during mitosis, has a network of constitutive centromere-associated (CCAN) proteins associating with it during mitosis. So far in vertebrates at least 15 centromere proteins have been identified, which are divided into several subclasses based on functional and biochemical analyses. These provide a platform for the formation of a functional kinetochore during mitosis. CENP-S is one that does not associate with the CENP-H-containing complex but rather interacts with CENP-X to form a stable assembly of outer kinetochore proteins that functions downstream of other components of the CCAN. This complex may directly allow efficient and stable formation of the outer kinetochore on the CCAN platform.	25.00	25.00	26.10	25.50	24.10	24.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.38	0.72	-4.16	24	170	2009-11-05 17:40:01	2007-01-02 12:50:08	5	1	155	12	127	175	0	73.10	33	50.36	CHANGED	stphlsRllp.p.Fcs.ppT+Isp-AhpllscYlclFVcEAltRut......pcsputpp...........lchpcLE+.lssQLlLDh	.................chls+lLp...t.Fps..ccT+ls..p-..AlplsucalclFVpEA.ltRust.......tpscsttt...................................l-l-cLE+.lhPQLLLDF..................................	0	33	66	104
+9248	PF09416	UPF1_Zn_bind		RNA helicase (UPF2 interacting domain)	Mistry J	anon	pdb_2iYK	Domain	UPF1 is an essential RNA helicase that detects mRNAs containing premature stop codons and triggers their degradation.  This domain contains 3 zinc binding motifs and forms interactions with another protein (UPF2) that is also involved nonsense-mediated mRNA decay (NMD) [1].	25.00	25.00	25.50	29.80	23.20	22.30	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.12	0.71	-4.63	16	324	2009-01-15 18:05:59	2007-01-04 16:32:50	5	7	266	6	238	323	3	142.70	57	14.31	CHANGED	HACAYCGIcsPssVlKC...sCsKWFCNu+ssT.uuSHIVsHLV+S+H+pVsLHs-SsLGDTsLECYNCGs+NVFlLGFlsAK.sEsVVVLLCRpPCA..pt.+DhNWDsspWpPLI-..-RphLSWlspsPS-p-..h+AR.IT.pQIs+LEphW+sN	.......................HAC.uYCGIHsPusVVpCs..sCpKWFCNu....R.G....sT.SuSHIVNHLVRA+HKEVpL.....H.-usL...G-TlLEC.YNCGs+NVFlLGFIPAK..uD.oVVVLLCRpPC......A.s..s.u.KDhN.WDsop...W.QPLIp..DRsFLsWLVp.hPS-.pE.QLR.AR...pl.ospQIsKLEEhWKpN.......................................................	0	88	129	199
+9250	PF09418	DUF2009		Protein of unknown function (DUF2009)	Mistry J, Wood V	anon	Pfam-B_18128 (release 21.0)	Family	This is a eukaryotic family of proteins with unknown function.	25.00	25.00	49.70	25.80	18.10	21.80	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.45	0.70	-5.71	11	144	2009-01-15 18:05:59	2007-01-05 15:47:23	5	7	77	0	106	145	11	364.20	38	78.36	CHANGED	c+A+YIPlRLo.-ERKlLRLLEAALpVS-YTD+VDllSh.pS+sKRlspQLKEhCulLsGLlVA.DhKtGpcLlcpK-FsspAcaFQslFEIGRRYKlMNP-+MRosYGKlhYMlQDSh.s-lpc.tLGFslhKPIhTVapaLppps......uhslLpDshl.hAhscl.P.sKsRsplp+tI+pKEpAlEpLu++YSs..uthscE-lc.slYSluDtNualptNR-Plp+MLphLcpaFsPssspch.asLuIphGtsGARLoHsHc+QaaYVhQSLoLWppIh+-MFpLWhlA-tDLhsssp.YcLssTGQGLNRlQtCPslh+AhcplLpcspccht.sWVGSSVlHLGDcsVPNALaFIDKYsQVsRILIPllpsltpIcsL.csDtplhsYIcppaGusppL++sILpDFF+HuFDGSGuDNaaDAGSCIDGRLTSAWNWsNpIpKKpYYsIFLhoGFouF-G	...............................................spalPlRLs.pERphLcLl-us................LpVS-YTD+lD.h.p.........h...h..................s.psp+hhtplcchhshlsGLhlut.....sh....c.Gpp.lhp.p.+s.htt..t.phhpphFEluRRaKhhNPpphRspYGKhhahl.Du...pltc....hlta...p..hhpslpTVhthLp.ptt......s.thlp.D.hl.hsh......l...........................lpp.lptKct..uhptl.pcYss..pthpp-plcpslhSlsD.psalt.NppPhpphlphLppaa......pPtp..p........t........hoLuIp....................Gt......sGuRLoHsHppQa.YVhQSLhLWppl.ppMhpLW.hu-pD.hL.ss.pt.YpLhsTGQGlpRhptsPph.phMppllppsppph.s..tWVGSsllHLGDcsVPNuLhFIDKYsQls+IL.Plh.sltpl.pl...........p..p......t................httalpptauuhpphphhILtDFF+HuFDGSGuDNh..uGSCIDGRLTSAWNWCsplp+K.aashFhhsGF.GF-G...............................	0	59	79	102
+9251	PF09419	PGP_phosphatase	DUF2010;	Mitochondrial PGP phosphatase	Mistry J, Wood V	anon	Pfam-B_22310 (release 21.0)	Family	This is a family of proteins that acts as a mitochondrial phosphatase in cardiolipin biosynthesis. Cardiolipin is a unique dimeric phosphoglycerolipid predominantly present in mitochondrial membranes. The inverted phosphatase motif includes the highly conserved DKD triad [1].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.90	0.71	-4.90	16	326	2012-10-03 04:19:28	2007-01-09 14:34:34	5	8	304	0	187	825	133	152.60	27	70.39	CHANGED	lsu.slslhpLlhsPSLhlPHlsVsoFspLPhsl..................hppssI+AVVLDKDNChshPccsclassYpcphccL+.........psasst.plLIVSNoAGosc.DhstptActlE+soG..lsVLRHs.........hKKP..GCtcElhsYF+pp.h..lppscElAVVGDRLhTDllhANhMGuauVWlp-GVp	............................................................................................................thhhPphhl.........s.sltpl..shth...........................LpptuI+ullhDhDNs....Ls..ppsplhs..p..hh....ph.hcch+...................pt.hst..tlhIVSNss...........st..ppsp..tlp...pths.............l..slt.as......................sK.KP....ts...h...p...cl.hp.hh.....t..tp.........................t.........s.pclslVGDRlhTDllhuNh..h.G.aslh......h................................................	0	72	121	162
+9252	PF09420	Nop16		Ribosome biogenesis protein Nop16	Mistry J, Wood V	anon	Pfam-B_6406 (release 21.0)	Family	Nop16 is a protein involved in ribosome biogenesis.	25.00	25.00	27.70	28.50	21.10	22.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.15	0.71	-4.14	45	332	2009-01-15 18:05:59	2007-01-10 16:36:55	5	4	279	0	223	301	1	178.70	25	84.52	CHANGED	lR++++s+uuhs+ss++pts+p..t...+plsh.s..sslI.......tp...sWDcptTlsQNYp+LGLsschstss........................................................shtph..spscltRDspss.l..h.....................................................................pttpspllppLEc.......App.s.....+pt+phSccE..pcalppLlcKHG.-DacAMthD+KLNhhQpotupl+...R+lp+app	.......................................................................................................................................................................+p+p+ppp.thpss.p+ph.p+p............+thshht...sshl.........tp......sWDcptolpQNapchGLssc.Ntss..........................................................................................s.ppht.tphc.lpp-.....tps.t.........................................................................................thppspVlppLEp........p.Ast.p............+ptpphSccphcalppLlcKHG....-D...YcAMspDcK.N.hQpT.tpl+++lppah.t............................	0	77	120	183
+9253	PF09421	FRQ		Frequency clock protein	Bateman A	anon	Griffiths-Jones S	Family	The frequency clock protein, is the central component of the frq-based circadian negative feedback loop, regulates various aspects of the circadian clock in Neurospora crassa [2]. This protein has been shown to interact with itself via a coiled-coil [2].	22.40	22.40	22.60	25.60	20.30	22.30	hmmbuild  -o /dev/null HMM SEED	989	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.00	0.70	-13.94	0.70	-6.78	4	63	2009-09-11 06:31:12	2007-01-17 12:55:18	5	3	35	0	55	66	0	625.70	32	95.98	CHANGED	RssPhsSpGHPLPRRsSP-pSlTL+pHRLARDAS...lpuShhusssspsQ.sSSssRRsSSGESp-TGQSDsppWFsQSNpNPsAsF..-SNhM-VDPPFYQKEoDSSNE-u+hP.ttsPs........shh+sosAHSSSADDYRSVIDDLTVE.pRLKEELKRYKQFGSDhMRKEKLFEIKVHGLP+RKKRELEATLR-FAASL.GsSSp..SoSpR...+KsuRHusts+....SuusShSKHsSSSS.S+SRPVDSAYASMSTG.....spSSGsSLsRPShouttpTupQKVEsYLRDhP-GLhP+HllMT-KEKKKLVVRRLEQlFTGKIuG+phpRspo..hPuhsuuLss..............pGpthu..pPPs..............EshREApI..Q-sp.sc...KpppS+DssSASNSstDQTEsGGsssuSGsGssSG....sNTSPPhs.sP-QRPTRPRDLDPDRlQIPSENM-YIRHLGLVsPEhLpsSpsphp.DVAPDAEGWVYLNLLCNLAQLHhlNVTPsFIRpAVsEKSTKFQLSsDGRKIRWRGGTDGTKFSSDSStDpSQpSPhTDDTEDuSsKNG+RKKpKsppAcSphuphs.S+..........usSDoFHYKPhFlHppuSStETSLE-u..uS.Gs...l-ESs.usS+WshSGSGsTpQRRKRRhDGAIVYYoGAPFCTDLSGDPGDh.........SPss.MpuutctcusupG.........ctschV..RohSGSSLshRPLSDs+hpluph.cFsPtN.....P-LVsDsGspssD.-h.FPWs--PthlcVpPL.....EPSGLGGVLPDDHFhllVTTRR...shRPs.ppp.LuRopoSE..-Ts-hIspRLAohpTS.....PhP.Pps++Lss....u.lpIEYlSGch+RLNPssLPPPAIFaPPFSoDSSasstDDLuSDs-.....-E-s.SEt.MSRRANPH.SDNp.Y.ccsDLu.ssEss.c.Ds-.......cDhchuuDpGts.RuhhspscuVcGsupPhusssG+-sshh+TGSSsATAGGsESGYSSShE-	......................................................................................................................................tt.st......sp...s.pWappss.psh.......t.h-........p.s...pps.p..p........pt....t...........................................................sp.usss--aRSlIDDLTl-.ppL+pcL++Ycp..ss.shhcc-KLFEl+haGLPtcK++ELEthLRpFsssh..t...s.t........s.....t.........tt..............ptts.Ss.......-SuYsShS.t.u.....stsptss......t....h..t.......p..t.tphpsaLp-hPtGLhP..p...h.ho-+p+KphlV+RLEQlFsGc........t.....................................................................Es.+EAph..................t......................................................................scQRPTp.hDlD..R.......hpYhppLsh.s.p..................cGWl.LNLlhshAQLHhhsVsstFl+pAl.thSs+hplS.DGpKlRW+GG.psTphSup...u.....ttts....tp..h....t.tt.tphppt......t.t.....t........s...t....t..................................................ptFhYcPhFhp.....sst......ss....-tt....S..s............pps....st.st..hs.sh...t..........p.pp.-GshhaYsss.FChDLSGD..hsh.........p..ss...h..st.p................................ps.SGo.....h.hp.Phsp.......................t..........sp..t.......p....hspt..t.......t.......h......ssGlGGV.PtDpFhhhV.o++...............................t........................t..p.......l..pth...sth..ps.............................lph-hhohphp.L.PssLP.Ps.ah..as.ssp..t....s...p..s.........................................................................................................................................................................................................................................................................	0	8	23	51
+9254	PF09422	WTX		WTX protein	Bateman A	anon	Bateman A	Family	The WTX protein is found to be inactivated in one third of Wilms tumours [1]. The WTX protein is functionally uncharacterised.	21.20	21.20	21.40	21.80	20.20	21.10	hmmbuild  -o /dev/null HMM SEED	471	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.70	0.70	-5.53	9	168	2009-01-15 18:05:59	2007-01-17 13:40:10	5	3	40	0	96	163	0	267.30	25	53.70	CHANGED	psls+SKTHDGL...........pctspususssphssstShsssP.....s.t..sspShstuhsFhShl++uutppsttu.....phuhs+pK+GLKGlFSShRh+RKsK.ttt-.p.s..pt.ttshhhstp.suSh.pl.......E...pshcc................susc.sssssppsPupspstsssPstsspp.usth.sstsh.ts-u.hps..st.tth..s................................uss-PPu-PSsDpLCh.hFsDVTSLKSFDSLTGCGDIIAD.-.-...GsSsssp..............................................hsusGptssu....thcpsuslVsYQGGGEEMASP-psD......................-s-hpchW-hlspo--pppt............s..hPths.....p.hh..uspssc.....+c.splcsttLtclPl.........ppt.p.t.tsPps-ptEusPsSDEGYaD..SsTPG.E--s...uu.s..p+sslPRDShSGDALY-LY.DP--u.....httusp-ssslSph+shSt.hhs.Ph	..............................................h.pspoh-sh.......................................t...........................tph...h.....................t...t......................sh.+.t+sh+shFp.h+.ppp.....................................................................................................................................................................................................................................TGCG-lhA-...........S..hs...................................................t.t....t......pptsshsshQGusEphA.Ptt.-...................t......tt...ht....t.....t........................................................s..t.............s..t...h.......................t..pp..Es.ssSDEGYaD..ShoPs.p.-t...........t.hhsRDShSGDtLY-ha.-Ppt..................................h................................	0	4	8	30
+9255	PF09423	PhoD		PhoD-like phosphatase	Bateman A	anon	Prosite	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.82	0.70	-5.92	148	1704	2012-10-02 19:15:56	2007-01-23 14:55:29	5	31	861	2	812	2178	650	392.20	20	71.03	CHANGED	hGVASGDPtsDulll................................WTR...lss..............................s.......slsVpaElA...s.........DtsFp.........p..lVppGss.hsssc..hDaoV+..........................V-lsG................LpPsppYaYRFp...s...........stSssGRsRTs....sssthpp....l+hAhsSCssa............pGa...................assYcphAp....p.s...hDhVlHLGDYIYEh.............t.t.h....sppth.p......t...t-.................hhTLsDYRtR....auhY+sDssLpuhHA....phPalssWDDHElsNNhh...tsusp..................ttsattR+ssAhpAYaEahPl............R...........tss.s.....................hp.l..........YRphpaGsLsclhhLDTRpa+s..........................................spsh.h....................................................................t.h...........................s....ssRolLGtpQppWLhppLt.......sSp...upWpllupQlhhuphshss..........................................................t.shshDsWD...........GY.spRpclLpth...p....pt.slpNsVhLoGDsHpsaAs-lpss...............ttt..p.s....lusEFsssS....loSsuh....................hst.lhst.sPclpahshsp...............RGYs........plc..hsspphpsca	..................................................................................................................................................................................................................................................................h.hth..................t.....t............................................h................h..............t.....s..a.ss...p..........................htht.s................L..ss.p.h..h.Y...p.h.h.................................s.....h....G........p......hp...Th.......stt...tp...................hphsh...sSCt...t..h.............t..uh....................................................................hpha.p.p..hsp....................p......Dh.hlahGDhlYt.s...............................h........................................................................h..s..l...t.c.....Y.R.....tp........a.t.....h.h..........t....c......s.......s.......lp...t...h.p..u.............phP..h........l.h..hW.........DDH.........E.l.t.sshh........ttt..................................................tsh...t...t.h.t..t..s...AhpAa..h...E...a..h..Ph...........................................................c.................t...p............................................hpl.......a..c....p....h....p.....a.....G....s....h.....h....p....lh..h.LDsRpaRs...............................tpt...t.........................................................................................................................................................................s...sspsh.lG....t....p....QhpWLhpt........L.t...pup...........upW.p..l..l..us..p.h....hs....h......s..................................................................................................h.s..h..-.s.Ws.............G..a.....t.p.pp......c...lhphh...........tp....t.....t.....h....p.....s....hl..hLoGDhHhs.hs.t.c.ht.t....................................................hhEhssss............lst.......................................................................................................................................................................................................................................................................................................................	0	272	518	709
+9256	PF09424	YqeY		Yqey-like protein	Bateman A	anon	Bateman A	Domain	The function of this domain found in the YqeY protein is uncertain.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.67	0.71	-4.34	42	2465	2012-10-02 13:42:24	2007-01-24 12:41:00	5	3	2421	1	718	1873	2150	142.00	36	94.47	CHANGED	+-+lppDhKpAMKA+DKt+LuslRhlpAAlppcElctpt....c.LsD--llsVLsK.lKQR+-SlppappuGRpDLs-pEpsElpllppYLPpQLo--ElpshlppsIu-s...GAs.....uh+DMGKVMuslps+ltG+A.DhutlSshVKptL	.......................................................................................pplppDhK.pAMKAK..D..c.+..L...sslRhlpAAl..ppt-.l....ctpt.........................p..L..sD-.c..ll..slls+..lKQR..+-Slpt.appu...G..R.p..D...L.A-p....EpsEl.sllppY...L........P....p......pL..o--E.lpshl.c.ps....I....sc....s....G.As.......u.h.p.D.MGKVMssl.ps...+...l...t...G...+...A...Dsstl.uthVKphL........................................	1	253	495	623
+9257	PF09425	CCT_2		Divergent CCT motif	Bateman A	anon	Bateman A	Motif	This short motif is found in a number of plant proteins. It appears to be related to the N-terminal half of the CCT motif. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif [1].	21.00	21.00	21.00	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.76	0.72	-7.10	0.72	-4.40	18	348	2012-10-01 19:54:00	2007-01-29 13:51:09	5	9	35	21	176	437	0	26.20	60	10.36	CHANGED	PlAR....+uSLpRFLEKRKcRlss...ssPY.s	...........PhAR....K.sSLpRFLE..KRK-.Rlsu...tuPY..t......	0	26	104	145
+9258	PF09426	Nyv1_N		Vacuolar R-SNARE Nyv1 N terminal	Mistry J, Wood V	anon	Pfam-B_50964 (release 21.0)	Domain	This domain corresponds to the N terminal domain of vacuolar R-SNARE Nyv1 which adopts a longin fold [1].  In yeast it has been shown that this domain is sufficient to direct the transport of Nyv1 to limiting membrane of the vacuole [1].	25.00	25.00	151.30	150.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.97	0.71	-4.62	5	27	2009-01-15 18:05:59	2007-02-05 13:24:10	5	1	26	1	15	24	0	136.60	63	56.58	CHANGED	VSYVEVlcsG+olSSC..Ycsts.ssusYGslousscuss....TP-lFHsLIsDMVlPKVVslsGNKVTKMShsLIDGYDCYYTT..cscDsspVLVCFT+lDlPKILPIRlLS-LKphEst......DsDEhLSuslGsILDsFHcELloYRNp	VSYVEVI+sGcTlSSC..Fpshp...pspsYGolsss...scph.................TPslFHpLIhDMVLPKVVPIcGNKVTKMSMsLIDGFDCaYoT...-D......cDscTVaVCFThVDIPKILPIRlLStLpchEuN..........uTsEhLSuHVGpILDuFHEELlpYRNp.	0	1	6	12
+9259	PF09427	DUF2014	SREBP_C; 	Domain of unknown function (DUF2014) 	Mistry J, Wood V	anon	Pfam-B_71890 (release 21.0)	Domain	This domain is found at the C terminal of a family of ER membrane bound transcription factors called sterol regulatory element binding proteins (SREBP).	20.20	20.20	20.70	64.90	17.60	19.80	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.58	0.70	-5.25	8	72	2009-01-15 18:05:59	2007-02-05 14:12:33	5	3	72	0	59	73	0	263.90	50	26.35	CHANGED	+shKaoLRsllG.psY..uaLTGsoE.....EpEtARlKAWsIALDAQLsGGDsElSKSRLsLTlhASGTLPcTPtRlMLKALHsRVLLWcl....ssshplsspluuclARhpWNtARphpphLsp......ucccsLPEHLAsLLEp-.sDDVhssuIlQRAaNLA.WNRsTscsshsp..ssuhDsVVEDsAl+SPLDALAAWYSSpsLp+sLhpoL...pspsts.....upcshhscIslAlplAPhsSsAphRALVA+AVlhsccRussIssALsAls.spss	.............+shcasLRsllGh+hY..uhLTGlTE.....EpEtARVKAW-IAlDAQLsGGDsElSKSRLlLTlhASGTLPcTPtRlMLKALHsRlLLWclu..suhshtluNtlAtpLARhpWshARphpchLsp............sp-DsLPcHLAsLL-tD.CD-VhsDsIlQRAtNLA.WNRsTp-ssssc..pshhDsVVEDsAlpSPLDAlAAWWSSphLQcALlpsL.....-hssss.......................hcspcshppplclAlclAPhsSsAasRAlVs+AVhh-ccRsssIsssLtALs.p.ps...	0	10	26	46
+9260	PF09428	DUF2011		Fungal protein of unknown function (DUF2011)	Mistry J, Wood V	anon	manual	Family	This is a family of fungal proteins whose function is unknown.	24.50	24.50	25.00	27.70	22.50	24.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.09	0.71	-4.27	37	112	2009-11-20 16:11:53	2007-02-05 17:05:15	5	2	109	0	85	112	0	149.10	29	52.01	CHANGED	+lpLRpso........schlss.RshsYYFsp.s.tp...........................+cpFpsuAlou-slhphup.hsas.......tsphPWRVlclp.....pttsphppp...t.................t...p++++PGKK+Rlth+pp.............ttcp.....tccp.......-t-K+..........p++p+cKKh++...............Rtpp+p+	.......................+lpL+p.s........tthlsstRPhsYYFus.pttp...........................+ppFppuAVou-sllptup.hsa...................usphPWRVlclp..ttssphctptt..t............................................pctpp+++RPGKKpRlshRtp.............ttcp......pEcp.....p+-K+..........pR+N+cKKh++....Rtpc+pp..................................	0	14	41	71
+9261	PF09429	Wbp11		WW domain binding protein 11	Mistry J, Wood V	anon	Pfam-B_13108 (release 21.0)	Family	The WW domain is a small protein module with a triple-stranded beta-sheet fold.  This is a family of WW domain binding proteins.	21.10	21.10	21.70	21.70	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.64	0.72	-4.00	30	272	2009-10-15 16:14:36	2007-02-06 10:25:24	5	9	212	0	198	259	1	77.90	41	17.48	CHANGED	c+shNPs-utRKppKcKElKKsKp-RpptRcttlt++sPcplpcplccLcph.EtsttL.....pstc+p+lcpLEcslchlt+	.......tK.hNPsDttRK.......pt+K+ELKK..........NKcpR.hsRss..hLtt..KDPcpIhcph-cL-ph..Ehss.h......................cps.+c+hcpLccshctlh...................................	1	63	99	149
+9262	PF09430	DUF2012		Protein of unknown function (DUF2012)	Mistry J, Wood V	anon	Pfam-B_49614 (release 21.0)	Family	This is a eukaryotic family of uncharacterised proteins.	26.60	26.60	26.60	26.70	26.50	26.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.55	0.71	-4.28	26	303	2012-10-02 19:08:27	2007-02-06 12:46:16	5	6	253	0	216	352	5	118.10	28	48.11	CHANGED	hsstshhsssplhL............su......................spa...hshl+pDGoFshpsVPsG....oYll-lpsssahFss...lRV-ls......psphcutplshhpstpsh.........................hshPlhlcshuhtpYa..Rcpaslhsl..LpsPMlLM	......................................th.sss+lhl..................su..................................spt...huhlppDGoFshpslP.s.G............SYll-lt....s..sahFpP...lRVDls................ttphc.s....ph...lshhpst....p.s....p...........................hsh....P.Lph.csh..u.hpYappRcpa..shhsh..L.h.NPMlLh.................................................	0	76	117	175
+9263	PF09431	DUF2013		Protein of unknown function (DUF2013)	Mistry J, Wood V	anon	Pfam-B_11317 (release 21.0)	Family	This region is found at the C terminal of a group of cytoskeletal proteins.	21.40	21.40	21.80	22.70	20.20	21.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.73	0.71	-4.42	23	255	2009-01-15 18:05:59	2007-02-06 12:52:43	5	8	227	0	183	253	1	139.20	34	23.37	CHANGED	ss-.hs..hl+LLLslNEQahhsuht..............pNtVhchL..............ptssh+sFsEpLlLhlNR-pDs......lplh.........lLKhLYLlFT...ossThchFYsNDL+VLlDIlIRpLssL......ssctchLRtTYL+VLtPLLppTplpch...Y++s-lhcl	..............................................................s.p-.h...hlplLLshN.pahhss...................................pNhlhpsL..............pts....sh+sFsEpllLLLN.Rts-s....................lplh..................lLKhLh.lFo...os..sT.t...p.hFYsNDl+VLlDIllRpLhDL............sssstLRhpYLclLhslLppTphpp......a+ps-lht.h.................	1	60	94	148
+9264	PF09432	THP2		Tho complex subunit THP2	Mistry J, Wood V	anon	manual	Family	The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1 [1].	28.00	28.00	29.10	31.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.71	0.71	-4.29	5	26	2009-09-11 02:57:22	2007-02-06 14:47:07	5	1	25	0	15	20	0	127.80	61	49.81	CHANGED	hLpYINLLs+LSVDLA+QlEsuD..sssclhV-+hsPPsELQulLcpYss...-ss-scsLRAcLp+YLD-IKMsRAKYuLENKYSLp-oLppLTKEVScWRccW-sIEsLMFGDuPsSMK+MlQsIESlK.cpLTs	..hLRYINLLcRLSVDLAKQVEVSD.PSVTVaEhDKWsPs-cLQuILEQYss...P-TDIcslcAQlcsYLDQIKMuRAKauLENKYSLKEpLsTLTKELN+WRKEWDcIEMLMFGDsAHSMKKMlQpIDSLK.Scls.u...	0	1	6	12
+9267	PF09435	DUF2015		Fungal protein of unknown function (DUF2015)	Mistry J, Wood V	anon	manual	Family	This is a fungal family of uncharacterised proteins.	20.90	20.90	21.50	41.90	20.80	18.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.69	0.71	-4.36	20	119	2009-01-15 18:05:59	2007-02-07 13:30:17	5	1	117	0	90	111	0	120.20	43	87.04	CHANGED	Ms..hllYhhshhlllsuT.hlahsRpRWhsh....h...........lschhYs+Ls....SFssDlEAGLSSosFDLuu.Nl..ssuDsRuGLD-puKcEIp+IM+pcplsFD-ARhlYhcc+FucNsIuPD.GpPRDPK	..............................hha.h.hhhhllhss..hhahhRp+hh.h...........................hsshhYs+LP.....SFpsDlEuGLSSusFDLsu.Nl..ssuDsRuGLDctuKcElh+IM+pc.plsFD-ARhlYhcp+FscNs.IGPD.GpPpDPK..	0	23	49	79
+9268	PF09436	DUF2016		Domain of unknown function (DUF2016)	Mistry J	anon	Iyer L	Domain	A predicted alpha+beta domain that is usually fused N-terminal to the JAB metallopeptidase. This protein in turn is found in conserved gene neighborhoods that include genes encoding the bacterial homologs of the ubiquitin modification system such as the E1, E2 and Ub proteins [1]. The domain is also known as the JAB-N domain.	19.80	19.80	20.00	22.90	19.10	19.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.31	0.72	-4.41	14	40	2009-01-15 18:05:59	2007-02-07 13:38:47	5	1	34	0	23	41	0	71.90	37	32.17	CHANGED	hDthLQssFPolhsP+aGs.lsshppsGcRhllAusGlalElpRsWLcslpplu...t.psslPYGplscplchh	........................hDtsL.suhPoVhVP+aus...lssh..p..psGcRlLluusGlalElpRPWLcllptlu...s.sstlPYGsVpEphchs......	0	4	12	19
+9269	PF09437	Pombe_5TM		Pombe specific 5TM protein	Wood V, Bateman A	anon	Wood V	Family	\N	19.10	19.10	131.50	41.20	18.00	16.50	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.83	0.70	-4.96	2	8	2009-01-15 18:05:59	2007-02-07 13:40:20	5	2	1	0	8	9	0	120.00	34	85.26	CHANGED	uhhcchNoQ.NR.M........ppSshs.pNIs..hhslhIsc...TspYClAs+.........................................lLlaL.Y...................ChYI..au.s.olppphcpasFus.slhappFas..c...FlRTp...........uhs.hRThsKa.hI....IlhulppVhh.p.hpcsYsho-I.DhhQ.......................sYpNss.uRFhpR	.....uhhcchNoQ.NR.M........ppSshs.pNIs..hhslhIsc...TspYClAs+..................................................................hChYI..au.s.ohppphcpasFus.slhappFas..c...FlRTp...........uhs.hRThsKa.hI....IlhulppVhh.p.hpcsYsho-I.DhhQ....................................hh..........	1	8	8	8
+9270	PF09438	DUF2017		Domain of unknown function (DUF2017)	Mistry J, Iyer LM, Burroughs AM, Aravind L	anon	Iyer L	Domain	This is an alpha-helical domain found in gene neighborhoods that contain genes encoding ubiquitin, cysteine synthases and JAB  peptidases [1].	25.00	25.00	25.10	33.00	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.15	0.71	-4.71	19	377	2009-09-11 16:56:57	2007-02-07 15:24:14	5	2	375	0	100	254	96	175.00	33	92.35	CHANGED	ht+ppshtGsphputl-PtEsplLpsLsuslhshLpp..pstsuPpD.LutlsGh.sGpsp.PpDPsLtRLLPDhaps-s-ss.ss...........uthRpLpEs-lhcsKhssuphlhcsL......Pts.....usclpLot-pAcAWluuLNDlRLsLus...tLclss-ss........-t..s-cshs.phslYpWLTalQESLlpAlhu	.................................................................................................t.th.s.ht.hEhtlLtslssth.thltt...........t.....t...p....ss.s....t.D..Ltth.h...u.......................ss.........sp.P.........p..DPsLtR.L.LPDha+sD-pss....................uthRsh+Es-lhsAKhtsApslhssl................scs........uuplpls.ppApsW..lsulNDlRLslustLsItscss...................tchst.p.c...s...ts...s.chsVYp.WLshlQEsLVpshh........................................................	0	31	77	96
+9271	PF09439	SRPRB		Signal recognition particle receptor beta subunit	Mistry J, Wood V	anon	Pfam-B_7840 (release 21.0)	Family	The beta subunit of the signal recognition particle receptor (SRP) is a transmembrane GTPase which anchors the alpha subunit to the endoplasmic reticulum membrane [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.17	0.71	-5.06	8	357	2012-10-05 12:31:09	2007-02-07 17:41:34	5	11	294	5	246	9068	2252	182.20	30	56.77	CHANGED	ospsslllsGlssSGKTsLFspLoTs.....shpcThsS..Esssuh+h...ps.+GsphTLIDaPGH-+LRhcLl-phhtpus.l+ullFVVDSol.sKclp-sAEaLYplLo.othh.csslsILIACNKp-lhhA+ssphI+puLEKElsplhcpRutuLssh..........-uss-tss.LsppGcsFcFspLcsp.V	...............................................t..tpslLL..sG.ss.SGK.T......s.....L....as......p..L..h.p.s........................................ph.t....t....T....h....T....S......h.......c...s.s.....s..s.h....t.h........................t..t..t...p..s...p...s..h...........p..L..l......D....h...P...G...........H..........t.......+......L..........R.......................p..............h.......h....c......h.................................................t................s..............p.........s........+..........u..........l.......l.......F..V..V...D.......o....s.......s.........h...p....c.............p....l........c...s..s.A..E...a....L...Y...s..........l...L...........h.........s...........s.p...........h.............h.........p.........p.............p........h.............s.lLl.s...C.NK.......p..D...h..........h....s.....A....c...s...s....p..h....l...+.....p...t.........L..E....p..El.s....p.....l..R.h.o..Rsts.lpsh......................-tst.p.............h....l.s..t.....u..p.t..F.pFpph......................................................................................................................	0	85	137	199
+9272	PF09440	eIF3_N		eIF3 subunit 6 N terminal domain	Mistry J, Wood V	anon	Pfam-B_4886 (release 21.0)	Domain	This is the N terminal domain of subunit 6 translation initiation factor eIF3.	25.00	25.00	25.40	26.50	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.68	0.71	-3.99	23	318	2009-01-15 18:05:59	2007-02-08 09:34:55	5	6	244	0	203	294	3	126.30	37	30.33	CHANGED	DLstKlhsaLDRHLlFPLLEFhusctha-p..........p-lhcA+h-LLpcTNM.sDYshslhpcl....sscphPsEhsp+RppVlppLpcLppcssplhclhpc.-llssl+o..D+stNlcaLp...cc+slTh-hlsuLY+aupap	.........DLTs+ls.aLDRHLlFPLLEFLss.....p..p.l..as-................c-llpuKh-LL.p..cTNM.l.Dash-lacpL........sc...-.........hPpchtc+RppV.lspLc.pLppcspslschhp.ss-sspphco.....Dpph.hc.aLp...cc....+.s......h................p.-hl.ssLYcau+FQ......................................	0	78	113	163
+9273	PF09441	Abp2		ARS binding protein 2	Wood V, Bateman A	anon	Wood V	Family	This DNA-binding protein binds to the autonomously replicating sequence (ARS) binding element. It may play a role in regulating the cell cycle response to stress signals [1].	25.00	25.00	28.70	27.80	24.60	19.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.08	0.71	-4.35	6	71	2009-01-15 18:05:59	2007-02-09 13:41:04	5	2	68	0	58	71	0	167.70	58	23.27	CHANGED	pRsLPsRc.Vos-oI-DAYsuFILYCNPsVshsTDTspLRcsFRsPPKS-GKSFSoasLFELI+pL-sKEIKTWupLAlcLGVEPPD.EKGQSoQKlQQYAVRL..KRWM+uMHVDAFFEYLLG+.HPYaspIPPspsPlu-htRDGVssE-DLALRALlPch+P+RGR+Ks--h--ss	.....s.RsLPsRc.lT.s.pTI-DAYVsFIhYCNPsVPhs...oDTspLRcsFRsPP+S-GKoFohFsLapLIcK.L-pK.ElKTWhpLAlcLGVEPPshEKcQSoQKVQQYAVRL..................K.....RWM+uMHVDAFFEYhlG+sHsYaTplPsssss..hs-..RDGVshE-DhALRALlPch+PKRGRKRs--cp..t.............................	0	10	27	45
+9274	PF09442	DUF2018		Domain of unknown function (DUF2018)	Coggill P	anon	manual	Domain	Acid-adaptive protein possibly of physiological significance when H.pylori colonises the human stomach, which adopts a unique four alpha-helical triangular conformations. The biologically active form is thought to be a tetramer. The protein is expressed along with six other proteins, some of which are related to iron storage and haem biosynthesis [1].	25.00	25.00	30.20	29.90	22.70	17.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.50	0.72	-3.42	14	194	2009-09-11 13:54:03	2007-02-09 16:45:20	5	1	193	8	23	82	2	81.60	53	91.25	CHANGED	FtGoP+-KFh-IlhpANpsllcpElEclhcchsshcplhEcp.Gls.........Epcl+sahhcpsch..lcsthsslYIEhhGcILopsE	..............FspoPKEKFhEIIpNuNhsslEK.hEchFtcalAM.ELLEKp.Gls.........Eh..-sK...sFILENuDh...IE-RpNDlaIELuAcILu+p.t.	0	6	19	23
+9275	PF09443	CFC		Cripto_Frl-1_Cryptic (CFC)	Coggill P	anon	pdb_2j5h	Domain	CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours [1,2] and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2 [1].  CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain [1].	20.20	20.20	20.50	20.50	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.17	0.72	-4.32	9	108	2009-01-15 18:05:59	2007-02-12 15:04:21	5	3	47	1	44	92	0	33.30	52	19.83	CHANGED	CGu.l.HGsWl.+uCpLCRChaGsLHChPpph.scCD	......CGu.lsHGsWl..+tCpLCRChaGtLHCFPpth.ssCD...	1	6	8	16
+9276	PF09444	MRC1		MRC1-like domain	Wood V, Bateman A	anon	Wood V	Family	This putative domain is found to be the most conserved region in mediator of replication checkpoint protein 1.	25.00	25.00	25.90	25.90	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.23	0.71	-3.87	12	137	2009-01-15 18:05:59	2007-02-12 16:05:59	5	3	132	0	101	140	0	137.30	40	11.45	CHANGED	hc+pshsshlEtEAEES-DEa.........tGlGGs............DsEto..--.su-lccMIDD...pstpchcscpltp.hhhpcppptDp+.lpKlLcDIpsGshR.+Rh...tNuh-h-lS.Ds-D-.lpphR.p..+Rc...hh+p+hLpssc...hspLscNsKupAFaco	.......c+pts+chlEppAEESE.DEa...................tGLGGs...................-sEsu...--p-spsccMIDD...tsspshcpcclst.hhApcp+ppDc+plpKLh+DIp.sGtLR.++R.....su.-...h-LS..Ds.-D.-thtph.Rht..RRcht.ch++tLLtscc...ltclucNPKppAFhco............	0	25	53	85
+9277	PF09445	Methyltransf_15		RNA cap guanine-N2 methyltransferase	Wood V, Bateman A	anon	Pfam-B_9480 (Release 21.0)	Family	RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyse methylation of the exocyclic N2 amine of 7-methylguanosine [1].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.12	0.71	-4.69	11	426	2012-10-10 17:06:42	2007-02-12 18:11:39	5	9	324	7	290	6417	1083	156.50	32	33.86	CHANGED	tphlLDlFuGuGGNsIpFAp....Fp.Vhul-hshp+ltpst+NAcsYGV.sc+lhhlhGDahp...........................................hlsph+htph...hDsVFhSPPWGGPsYpcppsaDLpp.plpPhslppllcs............shplopNll...lFLPRNosLsQL.....................................................splshclhssts+Cp.................lh.hppNGhhKulhsaaGpt	..............................s.hllDsFs..G..sG..G...N..s.I....p..F.....A..hp...............h...p....+..V...l..A..lD..hDst+lphA....c.+...N.....A....p.l..Y.......G..V.....s......-.......+...I....p..a..l....p.G...D.h.hp................................................................................................................l.h..t...p...h..p.................hD.s..V.Fh.S.P.P...W....G.G............P....s....Y.............t..p.............t.....p........s.............a.....c.l.p.....h......h....p....P...h..sh......plhph..........................hpph..o.p...p....ls.......ha..LP.Rss.slp.Ql...........................................................sph...............t..p....hc.................l.p...h.pst.pslhhhhs..h.........................................................................................................................................................................	1	114	171	246
+9278	PF09446	VMA21		VMA21-like domain	Bateman A	anon	Mitreva M	Domain	This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localised in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase [1].	21.30	21.30	21.60	22.70	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.16	0.72	-4.05	18	286	2009-01-15 18:05:59	2007-02-13 13:09:18	5	7	216	0	203	272	2	62.80	32	50.42	CHANGED	ssuVlhKL......................lhFoshMlslPlssaFshpthl..........hts..th...s..ssshhuGlsAslssplVLshYlhhAa	...............................ssltpL..........................lhFoh.hMlslPlusaFsspphl................hpu...............ss.shhuuhhAllssplVLshYlhhAh.............	0	50	97	165
+9279	PF09447	Cnl2_NKP2		Cnl2/NKP2 family protein	Wood V, Bateman A	anon	Wood V	Family	This family includes the Cnl2 kinetochore protein [1].	21.40	21.40	21.90	29.30	21.30	19.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.92	0.72	-4.30	11	88	2009-01-15 18:05:59	2007-02-13 13:17:23	5	2	87	0	64	79	2	66.90	42	34.58	CHANGED	sEppILssaLLssupL.sIISLppFpc...LFP+plpssPpI.csLY+-LQpQRp.pslDpVpspI-pEhcp	...oEssILsNaLLoPusLPolISLppFsc...LFP+pl.....po.cPpl.RsLYR-LQp.Rs.psl.DhVptNIcpEh+.t........	1	14	30	51
+9280	PF09448	MmlI		Methylmuconolactone methyl-isomerase 	Coggill P	anon	manual	Domain	MmlI is a short, approx 115 residue, protein of two alpha helices and four beta strands. It is involved in the catabolism of methyl-substituted aromatics via a modified oxo-adipate pathway in bacteria. The enzyme appears to be monomeric in some species [1] and tetrameric in others [2]. The known structure shows two copies of the protein form a dimeric alpha beta barrel.	29.60	29.60	30.20	31.90	28.70	29.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.55	0.72	-4.32	3	8	2012-10-02 00:20:33	2007-02-13 14:42:15	5	1	8	14	3	13	0	105.10	71	95.79	CHANGED	IRLLYLLVKPAGMSDETFRAECLRHYEMSHDVPGLHKYEVRLVAEQPTDTHVPFFDIGHVDAIGECWFKDDAAYATYMASDIRKAWFEHGKTFIGQLKPFRTAPVAGDEPAS	.....IRlLYLLVKPEuMScEpFRtECL.RHaEMStslPGLHKYEVRLVAp..pPTDTHVPFFDlG+VDAIGECWFcsEtsYpsYMsSDIRKAWFEHGKTFIGQLKPFhTtsVs......h.........	0	0	1	2
+9281	PF09449	DUF2020		Domain of unknown function (DUF2020)	Coggill P	anon	pdb_2i8g	Domain	Protein of unknown function found in bacteria.	25.00	25.00	38.50	42.00	20.40	17.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.75	0.71	-4.52	4	58	2009-09-11 14:12:22	2007-02-14 16:43:04	5	2	56	2	15	52	0	138.70	53	78.50	CHANGED	LPlDAhPtsP.GRsu.ptCPYLDocWVADTNGQRlTGhGsDERFsTPACVFWSYPEtPQhTVhVRcMsTp-DAIAVVDWAAPIDoTE.AEEPsGWSGGRRGGscpSGAlYAVQKsssAVlVaTNQ-QSLKAQLlAEEsIpNLGL	...............................P.....p.ss.....scCPYLDopWVA-TNGQRhsu.GlDsRFsTPACVFWSYs--PQhTVhVRcMsopp-AhtVVDaAAPIDoTEPAp....-PsG...WSGGR...tu.....ss...cGAlYAVpKGssAVVVaoNQpQSlKAchIAcEsIspLuL.........................	0	4	11	15
+9282	PF09450	DUF2019		Domain of unknown function (DUF2019)	Coggill P	anon	pdb_2i9c 	Domain	Protein of unknown function found in bacteria.	20.70	20.70	20.70	21.40	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.20	0.72	-4.18	7	37	2009-01-15 18:05:59	2007-02-14 16:49:09	5	2	22	1	27	37	0	101.70	31	82.69	CHANGED	sptLVtRFAclultQDsAlLts-hu+FNRLascMtplssELKpRsGDQRpALhsLasHPNMQVRLpAAKtTLAltPsEARppLEAIAsS+WhPQAGDAGMsLhpLD	..........pcLVtpFschshtQscAlhts-tpphN+hacchhtlhscL+u+ssst.RpuLhsLhcHPshpVRlhAAttsLt..htsscA+thLptlupt....................................	0	1	14	22
+9283	PF09451	ATG27		Autophagy-related protein 27	Wood V, Bateman A	anon	Wood V	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.91	0.70	-5.16	14	241	2012-10-02 14:19:22	2007-02-15 13:10:36	5	15	184	0	180	355	1	221.90	18	72.68	CHANGED	sshhhuhtsssuuhcCspppl...ppYclspluu.pslpsscsTPPopsphpahlslC......pcsshps.cpCsss.stlCulp.hhhsst...sshsopllshtpsspsshcthts............tGlplphsG.......tsauspphcAplpapC....ssstsusEhps......................................................sstssp.lclshps..uC.p................t...t.......ttsspsssppuss.....usthGaFTWLFlhlhLhh.slYllsGuahNasphuspsa.....-lls+u.-hl+slPhhh+-hlp+........llsshpG.........suuRG	..................................................................................................................................................................................hs..........................................................................................................................h.hs.s.....................C............hC.h...................h...hh....s....h.....................t.....t..p...t..........................u.l.l..hp.u............t...t....t....t.t...ps.lph...C....s..ph.p.t....p..h.........................................................................t..s...t......h.p..lphps...uC..............................................................ts.ttstp.......................usthG.aF...s.hlh...l..l.h...hlh.h.ssYllhGuhhshpt.hutpG.h.......-hlPph.-hhps.lPhhhp-hhth........hhtt.ts.........................................................	0	83	123	159
+9284	PF09452	Mvb12		ESCRT-I subunit Mvb12	Wood V, Bateman A	anon	Wood V	Domain	The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified [1], multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23) [1].	25.00	25.00	81.30	81.10	21.80	17.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.03	0.72	-3.81	4	24	2009-01-15 18:05:59	2007-02-15 13:39:10	5	1	23	1	15	20	0	91.10	53	88.18	CHANGED	hLR+IPLYNtatss..aP+cR.sKlplPthpl.shssTt-hLpsWhcECccIhcssp.+cppscpF-pWYpEpYLupKPPGllps....shLuPpRK	.lLR+IPLYNKYGc-..FP.p.EslsRhphPEaKLPsLQ.PTc-hLsPWYEECDsIs+s.CphHDuSsKcFDpWYcEpYLSKKPPGllss....slLSPSRK...........	0	1	6	12
+9285	PF09453	HIRA_B		HIRA B motif	Coggill P	anon	pdb_2i32	Motif	The HirA B (Histone regulatory homologue A binding) motif is the essential binding interface between HIRA Pfam:PF07569 and ASF1a, of approx. 40 residues. It forms an antiparallel beta-hairpin that binds perpendicular to the strands of the beta-sandwich of ASF1a N-terminal core domain, via beta-sheet, salt bridge and van der Waals interactions [1]. The two histone chaperone proteins, HIRA and ASF1a, form a heterodimer with histones H3 and H4. HIRA is the human orthologue of Hir proteins known to silence histone gene expression and create transcriptionally silent heterochromatin in yeast, flies, plants and humans. The yeast CAF1B proteins which bind H3 also carry this motif at their very C-terminus. 	21.00	21.00	21.10	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.47	0.72	-6.80	0.72	-4.30	30	239	2009-01-15 18:05:59	2007-02-15 14:15:42	5	22	194	2	167	262	0	23.40	48	2.46	CHANGED	pQpsThTKsGKKRlAPhLlSouss	.....KQp.ThTKDGK+RIsPlhlupss....	0	36	73	131
+9286	PF09454	Vps23_core		Vps23 core domain	Coggill P	anon	pdb_2caz	Domain	ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (Pfam:PF03997) and Vps37. Vps23 gives ESCRT-I complex its stability [1].	20.60	20.60	21.10	20.70	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.55	0.72	-4.36	19	362	2009-01-15 18:05:59	2007-02-15 14:37:13	5	6	269	7	223	353	3	62.60	44	14.79	CHANGED	-phltstsslhpQlhcLlAc-pAl-DsIhhLscuLcpGpIsl-palKplRtLuR-QFhtRhhhpK	.........D-lllsssslh+QllsLhAEEpAI-DsIahLucAL..c..+....G...s.....I....s...l.-saLKplR.LuRcQFhhRAhhpK...................	0	76	126	181
+9287	PF09455	Cas_DxTHG		CRISPR-associated (Cas) DxTHG family	Coggill P	anon	pdb_2i71	Family	CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins.  The family describes Cas proteins of about 400 residues that include the motif [VIL]-D-x-[ST]-H-[GS]. The CRISPR and associated proteins are thought to be involved in the evolution of host resistance. The exact molecular function of this family is currently unknown.	22.30	22.30	22.30	22.80	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.31	0.70	-5.31	44	268	2009-01-15 18:05:59	2007-02-15 14:47:23	5	6	191	2	136	269	9	350.30	14	81.01	CHANGED	hllohlGss.............pappspYphsspp...............hco....thsttulhchhp......sschllhssss.....................................t...sshptlpptlpsphtp........................pslhlP..............................cGpsps.hhp...lahpl.hcp..l......pcss.clllDlTHGhphhP.hlshhuhphhttlt.......................tsphcslhhuhapsps...............hsshh-lsthhplhchhhsspphhphsssp.lsph..hppt...h.......................tpthpphhphlpslspul.lshshph................thhpplhphlppthphtt.........................hhth.hh.hlpplhpphphhstpp....................lcphhclhc.hahcpt.h........hpuhhltpE...............hpphpptpt+pphppth............................................pp....hhphhsphtphRNhlAHuGhp	................................................................................................................................hlshhGts................tap.spYhh..tspp.....................ps........thht.slhchhp.........schllhhspp...............................................................pphpthhptl.pphh.p..................................................................phh.lP........................................pupspp.hhp......lhppl.hcp...l.........ppss.clhl..DlTHGh+.hP.hlsh..hshphhphht.......................th.p.h.ptl..hauhhpsps.............................t.sslh-ls.sh....h.pl.hchh.uhptahph.sp.s..p.ltph.......htt..............................t.hpth......hp....hlpphppsl.h..hhhth...................p.hpphhp.lpph.p..t.....................................................hh.hhpph...pph.t...ht.tp....................htp..hphhc.hhhpt.t..h.........puh..hlhp.....E....hhh...t.........h.ph.pht.tpt.ht..h.....................................................................................t.....................ht....ph.p.hRN.hsHsuh..................................................................................................................................................................	0	69	89	110
+9288	PF09456	RcsC		RcsC Alpha-Beta-Loop (ABL)	Coggill P	anon	pdb_2ayy	Domain	This domain is found in the C-terminus of the phospho-relay kinase RcsC between Pfam:PF00512 and Pfam:PF00072, and forms a discrete alpha/beta/loop structure [1].	25.00	25.00	37.40	35.80	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.95	0.72	-4.34	12	546	2009-01-15 18:05:59	2007-02-20 16:07:56	5	4	538	2	41	289	1	91.90	68	9.90	CHANGED	pCWLAlRNspLppaLpslLutpGlpltcYp.sppsss-DllIoD.ssphshtspAhIphspcHIG.spEppPG.WhpSsusspEL.sLLs+Ia	......pCWLAVRNASLCQFLETSLpRSG.lsVspYE.GQEP..sPEDVLITD-sls+cWQGRAsVsFCRRHIGIPLE+APGEWVHSVAuPHELPALLARIY..	0	1	9	24
+9289	PF09457	RBD-FIP		FIP domain 	Coggill P	anon	pdb_2d7c	Motif	The FIP domain is the Rab11-binding domain (RBD) at the C-terminus of a family of Rab11-interacting proteins (FIPs). The Rab proteins constitute the largest family of small GTPases (>60 members in mammals). Among them Rab11 is a well characterised regulator of endocytic and recycling pathways. Rab11 associates with a broad range of post-Golgi organelles, including recycling endosomes [1].	23.00	23.00	25.30	23.60	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.19	0.72	-4.16	19	430	2009-01-15 18:05:59	2007-02-21 13:42:40	5	10	90	10	225	398	0	44.20	41	7.00	CHANGED	o+-ELhphltcpEcpht+.......Lc-YIDsLLlplMEcsPsILcss	.................o+-ELhptl..hcpEc..t+.......LccYIDplLlplhEpsPsILcl....	0	40	60	129
+9290	PF09458	H_lectin		H-type lectin domain	Coggill P	anon	pdb_2ccv	Domain	The H-type lectin domain is a unit of six beta chains, combined into a homo-hexamer. It is involved in self/non-self recognition of cells, through binding with carbohydrates [1]. It is sometimes found in association with the F5_F8_type_C domain Pfam:PF00754.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.00	0.72	-4.32	87	326	2009-01-15 18:05:59	2007-02-21 14:07:37	5	22	127	25	229	344	33	71.10	20	18.43	CHANGED	pphppslpFs.psFpp..hPpVhlulphhD..hsps........psh..phplpspslTtpuFs.lphpshsss.plhplphsahAlss	..................hplsFs.psF..ps.....sPtVhlulshhD...hsps........tsh..phplpspslTps........u..Fs.lphp...s..hsss..tl..hph..p..hsahAh..t.......................	0	170	204	223
+9291	PF09459	EB_dh		Ethylbenzene dehydrogenase	Coggill P	anon	pdb_2ivf	Domain	Eythylbenzene dehydrogenase is a heterotrimer of three subunits that catalyses the anaerobic degradation of hydrocarbons. The alpha subunit contains the catalytic centre as a Molybdenum cofactor-complex. This removes an electron-pair from the hydrocarbon and passes it along an electron transport system involving iron-sulphur complexes held in the beta subunit and a Haem b molecule contained in the gamma subunit. The electron-pair is then subsequently passed to an as yet unknown receiver [1]. The enzyme is found in a variety of different bacteria.	26.20	26.20	26.30	27.10	24.20	26.10	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-12.05	0.70	-4.94	49	210	2009-09-13 05:32:36	2007-02-21 14:20:32	5	12	144	1	98	213	46	238.40	19	66.68	CHANGED	sssWsp....ssssplsl....hss.ssh.........................................................tsstpslpVpAsasucpl.ahhhpWps.........................................................................................stsh......................t.............tss.apD+lAlha..s..............s.tss.h.s..s........hpshssss.t.....................hhpahsss..................................sthl-l..WpW+u..t.........t.................t....s...........................................................ph........................tt.sht...s.p.p............................stsslpssu....a..psG....pWsVhhsRsLpss...s...-sshps.GpshshuhAla...-sspsp+stphu	.............................................................Wpph..hplsL.....hss...h.........................................................pthtt.lt.VpAsa....sup....pl.hhhhpWts...................................................................................................................................stsht..........................t.....................t.t.h.DphAlha..s.t...................sh.h.s..s..........s.hsth..h........................hhsss................................sthssl.ah..Wpu...................................................................s........................................................................................................t...pst..............................ts.t.htstu.....ph..tsG.....hWpl.hsRsLts.....s...t...psphp..Gt.h.huhAha...psp.hpp.hph...............................................	0	31	74	89
+9292	PF09460	Saf-Nte_pilin		Saf-pilin pilus formation protein	Coggill P	anon	pdb_2co1	Domain	This domain consists of the adjacent Saf-Nte and Saf-pilin chains of the pilus-forming complex. Pilus assembly in Gram-negative bacteria involves a Donor-strand exchange mechanism between the C- and the N-termini of this domain. The C-terminal subunit forms an incomplete Ig-fold which is then complemented by the 10-18 residue N-terminus of another, incoming, pilus subunit which is not involved in the Ig-fold. The N-terminus sequences contain a motif of alternating hydrophobic residues that occupy the P2 to P5 binding pockets in the groove of the first pilus subunit [1].	25.00	25.00	25.10	25.00	24.20	24.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.75	0.71	-4.41	4	84	2009-01-15 18:05:59	2007-02-21 14:30:22	5	1	81	19	1	51	0	138.30	60	90.19	CHANGED	GShlPNoEQppSVDlsFuuPppLolohsPVuGLhAG.ptustpIApLsVsSsohKpaulpG..hussVlsssGssWplsGKNoGptIpVsFuusshuppsus.paNG+pWhsaDhNDpLslhLsG.uQNVsADTYPlTlclsuYQs	.........GSFLPNTEQcKSVDISFAAPEcLTlSL-QsP.GLhAGKsKPsT.slAKLTVNSTS.IKEFGVR...G..VSsohl..NshGShWsITGKN.S.GsoluVGFS.......SpoLusS+SspsWNGl+WaTFDsN....DPVsIsLlt...DQNIPPDTYPlTVDVVGYQP......	0	0	0	1
+9293	PF09461	PcF		Phytotoxin PcF protein	Coggill P	anon	pdb_2bic	Domain	PcF is a 52 residue protein factor of two alpha helices, containing a 4-hydroxyproline and three cysteine bridges. The presence of the hydroxyproline is unique in relation to other fungal phytotoxic proteins. The protein has a high content of acidic side-chains implying a lack of binding with lipid-rich components of membranes and appears to be an extracellular phytotoxin that causes leaf necrosis in strawberries.	25.00	25.00	25.10	33.10	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.53	0.72	-4.06	5	31	2009-01-15 18:05:59	2007-02-22 13:45:16	5	2	5	1	11	32	0	44.60	56	36.26	CHANGED	QQLC+.AsGCAYEYScANtVVSKCC+AINs-PlAFHDCCpcSCNoG	QQLCp...AsGCA.Y.cYScANpslSKCC+sI.NscPsAFa-CCucSCNoG..	0	1	10	11
+9294	PF09462	Mus7		Mus7/MMS22 family	Wood V, Mistry J, Bateman A	anon	Wood V	Family	This family includes a conserved region from the Mus7 protein [1]. Mus7 is involved in the repair of replication-associated DNA damage in the fission yeast Schizosaccharomyces pombe. Mus7 functions in the same pathway as Mus81, a subunit of the Mus81-Eme1 structure-specific endonuclease, which has been implicated in the repair of the replication-associated DNA damage [1]. The MMS22 proteins are involved in repairing double-stranded DNA breaks created by the cleavage reaction of topoisomerase II [2].	21.10	21.10	21.20	22.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	614	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.13	0.70	-12.86	0.70	-5.68	17	141	2009-01-15 18:05:59	2007-02-22 14:11:52	5	5	120	0	111	150	1	490.60	19	29.02	CHANGED	hEthW.plhphhs......lsplsthshhhhssp.....tssWshlp.hhp.hh...p.t.t.........shspYtcs.....hhtRChhLhptasW..c.sp.llhp..LachFsppphhchcpEp.hppPt....h.lccLspsPohthpstp..hFchal+lLh.ulp.L...........tspcpl+shs.RlhPspshpYs+ppsl..tphs.LhN+asLLhsLhahsssshc.+lpplpp..lpstpuchcs.....phIslps.spLshhploppcchpsht.hsthhs.hlsphlcpah.hpt..p...........................hhpsFppphhcphhspspcplpshLphslpuhpshl............ptusshppsphllsps.lptlhph.p....pls....pcslphIpsaL..............tt......................tt..t...........t........................................................phhphlcplhp.slp..p.hsp.htts.s.-t.h............................................lhshlcsasphAphLVcpshp.hWs....hs...................astpsahtlp.sstpccas.hFhsphlphDstthp..chcpplhuhhhpsLlpphshlt.....pLhphlhsh.pps.hhp.hsh..t.....hplshsshpppcLsllosllpsh+...........................t.p.t+ppapchlpphhpsh+ssYtphtt........ut....ttahsFlp+llshl	.............................................EthWpthhthhs......h.phs.h.shhh.s.+............spWthhp.hht.h...h...t..s..t..........hspYhcs.....hhtpChhLhptasW....phsp.ll.h..lach....Fspp.phtshppEtshtp.P........................h.lpplstps.shthp....stp..sFchaL+llh.shp.h...............ptcplpshshRhlPspsh........pa.......s.cppsl..pphshLhN+asLLh..sLhhhss..s.s.hc.p..lptlpph..lp.tpucpcs.....p.lslcs.tpLshhtls...pt..c...sh.......ht.hhthhsphhpphlppa..htt..t.............................p.h.pphhp...h.ht..ppth.phl...h.s.hthh............ptt.....s...hhh......httlht.........th.........shthl.tah.......................................................................................................................................hpphht..........p.............t................................................h.thhp.a.thuthhlppthh..hs.....s....................hs..sh..ht.p....ppcah.hFh..hhp.ss...hp...php..phhphhhtslht.t............thhthl.p..................................htht.....ppphslhp.hhpshp................................................tt...ta.tphlp.hhtthp...tpht.h.....................t..........h.tFhtthlt..............................................................................................................................................................................................................................................................	0	27	60	98
+9295	PF09463	Opy2		Opy2 protein	Wood V, Finn RD, Bateman A	anon	Weod V	Family	Opy2p acts as a membrane anchor in the HOG signalling pathway [1].	21.10	21.10	21.60	21.10	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.06	0.72	-3.86	15	95	2009-01-15 18:05:59	2007-02-22 14:50:21	5	2	92	0	63	92	0	35.20	46	8.07	CHANGED	CVs.Csosss.oCPsCscGcpCshsStTCspCspThC	.CVs.Css.sss.sCP..s..CssuEhCsho.uhoCspCssshC	0	11	29	51
+9297	PF09465	LBR_tudor		Lamin-B receptor of TUDOR domain	Coggill P	anon	pdb_2dig	Domain	The Lamin-B receptor, found on the TUDOR domain Pfam:PF00567, is a chromatin and lamin binding protein in the inner nuclear membrane. It is one of the integral inner Nuclear Envelope membrane proteins responsible for targeting nuclear membranes to chromatin, being a downstream effector of Ran, a small Ras-like nuclear GTPase which regulates NE assembly. Lamin-B receptor interacts with Importin beta, a Ran-binding protein, thereby directly contributing to the fusion of membrane vesicles and the formation of the NE [1].	20.70	20.70	20.70	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.73	0.72	-4.34	5	85	2009-01-15 18:05:59	2007-02-23 17:27:58	5	10	51	2	45	73	0	53.10	54	9.68	CHANGED	MPupKYpcGElVMGRWPGSsLYYEVcVlSFDsKSQLYTVlYKDGTELELKESDIK	.........MPs.tKascGElVhGRWPGSuLYYEVcllSaDspopLYTVpYKD.GTE..LELKEsDIK...........	0	8	13	25
+9298	PF09466	Yqai		Hypothetical protein Yqai	Coggill P	anon	pdb_2dsm	Domain	This hypothetical protein is expressed in bacteria, particularly Bacillus subtilis. It forms a homo-dimer, with each monomer containing an alpha helix and four beta strands.	24.80	24.80	25.70	26.00	22.10	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.35	0.72	-3.97	2	32	2009-01-15 18:05:59	2007-02-23 18:12:33	5	1	25	2	4	31	0	63.30	35	82.67	CHANGED	MlENPMVhpNh......pc.s.hDh.I-.hhGsElhPsD-all.ssGEllLRENl.cYhhpQLGFEhKsAt.	.............t....................p...pEs-h.h-DhaGsElhssDcYll..ss.GEllLc-NLpcYLhEphGhchp..............	0	1	3	3
+9299	PF09467	Yopt		Hypothetical protein Yopt	Coggill P	anon	pdb_2dlb	Domain	This hypothetical protein is expressed in bacteria, particularly Bacillus subtilis. It forms homo-dimers, with each monomer consisting of one alpha helix and three beta strands.	25.50	25.50	25.50	46.40	22.20	25.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.42	0.72	-4.13	2	7	2009-01-15 18:05:59	2007-02-23 18:13:57	5	1	7	2	2	5	0	70.40	65	95.73	CHANGED	AGYLNNIALNLEIVLKNKADSPEVSETLVTRICENLLLSKEVSFLKADGSVENFKLSDMEYEITNTEELPE	..AGYLNNluLpLEIVLKNKAcs.EVSpoLspRlCEpLhlu+EVsFLpADGoVEpFKLsDhEYEIoNTEEl....	0	1	1	1
+9300	PF09468	RNase_H2-Ydr279		Ydr279p protein family (RNase H2 complex component)	Wood V, Chahwan C, Bateman A	anon	Wood V	Family	RNases H are enzymes that specifically hydrolyse RNA when annealed to a complementary DNA and are present in all living organisms. In yeast RNase H2 is composed of a complex of three proteins (Rnh2Ap, Ydr279p and Ylr154p), this family represents the homologues of Ydr279p [1]. It is not known whether non yeast proteins in this family fulfil the same function.	23.60	23.60	23.90	23.90	23.20	23.50	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.05	0.70	-5.22	42	345	2009-01-15 18:05:59	2007-02-26 08:50:54	5	5	278	16	229	334	0	283.10	21	86.68	CHANGED	s..s+lh.....lLPpssssst......hphlpLssPp.sspsstahh.....ppsplaElpthpt........................s.+Shhls.............................stlhpsuplhhsoshDslFlllshLhptt........................pspFhsl--ll......Dphhs...........thpphh.h.........hshlcpplptls-sh...............Esusc..pha+hsppKllpaLttKspphsph...l.pshp.phhpph...................................................................................th.pphhp.thhphuhshlsp.h.pphhpplhpt.hh............-ht.hpthhtt.................hppc+th.psh-uthsps...........pppppp.pttpKpsp...opst+....shtphsssGhp..plsuFF	...............................................t...hh.....lhs..p..t.t.........hphlpL....pPp..pu........psshalh.............p.pps..laElpthpt.........................th+SWhls.....................................................s.VtpsupLhhsTPhDslFllLs...hLhpsp................................ptpFhsl--ll.........Dp.hs............................thpplh.....................hthhcptlppls-sh....................................-.h..usp.....pha+hscpKhlpaLtpKspphs......ps....L.ts.p......phst.t...........................................................................................t..tp...p..hl..ph...Ahshlsphh.tp.....hh.ppl.hp.h....................t.t....t...................................p.p..........ptt...phs....................tp.tt...tt.ttpptt.......stt.c....th.t.ph.stpG..ht..plssFF..........................................................................................	0	78	128	191
+9301	PF09469	Cobl		Cordon-bleu ubiquitin-like domain	Coggill P, Bateman A	anon	pdb_2daj	Domain	The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node [1]. This domain has a ubiquitin-like fold.	25.00	25.00	27.70	26.80	23.30	18.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.68	0.72	-4.01	4	145	2012-10-03 10:59:06	2007-02-26 12:46:05	5	5	39	1	57	123	0	79.10	57	8.93	CHANGED	PsICpKCEFsPtHVlLL+DshupEEL-LsKSLs-LGIKELYAaDsp.............+EopphSSstss.o-KEKKuFLGFF+hsK+pps	......PlICuKCEhsPtHslLL+D..utE.L-LoKSLN-LGl+ELYAhDsp....................REohp.hS.....p...ss...p-KEpKtFhuFFptsK+pp.p.......	0	2	6	22
+9302	PF09470	Telethonin		Telethonin protein	Coggill P	anon	pdb_2f8v	Domain	Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerisation of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles [1].	25.00	25.00	41.90	41.80	19.00	17.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.02	0.71	-4.79	3	40	2009-09-11 00:10:22	2007-02-26 13:39:14	5	1	34	3	25	38	0	162.40	66	97.71	CHANGED	MATSELSCpVSEENCERREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHRQGQCQALVQRSPWLVMRMGILGRGLQEYQLPYQRVLPLPIFTPAKVGATKEEREETPIQLQELLALETALGGQCVDRQDVAEITKQLPPVVPVSKPGsLRRSLSRSMSQEAQRG	.......MAToELSCpVSEENpERREAFWAEWKDLTLSTRPEE..........GCSLHEEDopR+ETYHpQGQCQuLVQR.SPWLVMRMGILGRGLQEYQ.L.PYQRVLPLPIFTPs.KlGssKE.ERE-TPlQLpELLALETAL....G.....GQClDRQ-VAEITKQLPPVV.PV....S.....K.....P.GsLRRoLSRSMSQEAQRG.................	0	1	5	10
+9303	PF09471	Peptidase_M64		IgA Peptidase M64	Mistry J	anon	Rawlings N	Family	This is a family of highly selective metallo-endopeptidases.  The primary structure of the Clostridium ramosum IgA proteinase shows no significant overall similarity to any other known metallo-endopeptidase [1].	20.10	20.10	20.10	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.58	0.70	-4.76	14	251	2012-10-03 04:41:15	2007-05-02 11:06:12	5	20	205	8	66	360	113	241.70	28	47.19	CHANGED	apso--upcsstshppohphPssstssplshhph.tstpph.p.hphllc...P...c-.hhspstssssss.....lh.lhcoGs.spp+lDlllhG-GYTssEhscFhpDAp+hhcslFu.ppPa+pa+scFNVWulsssSp-S.........GV..upPpsshh+cohlGupassas..ERhltsscs+shppss...........u...hsPY-hl.......hllsNscpYGGuGhhsh........auslsucss.hushlhlHEhGHuhuuLADEYhsusssh.s......EPac.NlTs..sspth....KW	.............................................................................................................................t..h..........ts.hhp.t.t.tp........hhhlhpsus.sscplclsllu-GY..Tt....s..E...h...s...p...Fhp.D..A..ppth.-.sLF......u...tE.Pa+oh+stFNlhAVtssSp-S...........................Gl.......s.s......t.....p....s......h.h.....+..sTul.s..opF....s....s.ah....s...-R.h...Lss...s..phcshc.ssh............s......sssa.-.tl...............llLsNo.s...p...YG.....GuGhhss......................ashs.o.s..pps....h....hp.VllHE.h.G.HoFuGLuDEYhh.spss.h.th............thEPhc.Nlosh....s.s.t......KW.............................................	1	30	54	64
+9304	PF09472	MtrF		Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Many archaea have evolved energy-yielding pathways marked by one-carbon biochemistry featuring novel cofactors and enzymes. This domain is mostly found in MtrF, where it covers the entire length of the protein. This polypeptide is one of eight subunits of the N5-methyltetrahydromethanopterin: coenzyme M methyltransferase complex found in methanogenic archaea. This is a membrane-associated enzyme complex that uses methyl-transfer reactions to drive a sodium-ion pump. MtrF itself is involved in the transfer of the methyl group from N5-methyltetrahydromethanopterin to coenzyme M. Subsequently, methane is produced by two-electron reduction of the methyl moiety in methyl-coenzyme M by another enzyme, methyl-coenzyme M reductase. In some organisms this domain is found at the C terminal region of what appears to be a fusion of the MtrA and MtrF proteins. The function of these proteins is unknown, though it is likely that they are involved in C1 metabolism.	21.00	21.00	21.40	21.30	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.77	0.72	-4.73	9	59	2009-01-15 18:05:59	2007-05-02 16:24:54	5	2	54	0	38	58	10	63.30	32	52.29	CHANGED	slshsscPphsuIpshV-sl+Y+uQLlARspKLsSGltusshhGhslGhlhAllhlllP.hlhh	.............l.hsspPphsuIcshlEslcY+spLluRct+LsSGltssslhGhshGhlhAllLlslslhlh.h..	0	8	24	32
+9306	PF09474	Type_III_YscX	type_III_YscX; 	Type III secretion system YscX (type_III_YscX)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are encoded within bacterial type III secretion gene clusters. Among all species with type III secretion, those with this protein are found among those that target animal rather than plant cells. The member of this family in Yersinia was shown by mutation to be required for type III secretion of Yops effector proteins and therefore is believed to be part of the secretion machinery.	20.50	20.50	21.20	35.80	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.50	0.71	-4.09	6	77	2009-01-15 18:05:59	2007-05-02 16:41:22	5	1	74	0	10	33	0	121.50	53	99.75	CHANGED	MSR.IoAhHIGIEpLotlShEElssuLPcRatLLPDGQuVETHlp+LYPtp.u-QtLhsaApPphsFHsLLRPcDaRQthcs....LppLLppssospLptAusLLpppppD-RLLQMALNLLHKV	.........MSR.loAhHIGIEpLotlShE-lsssLP-RatLhPDGpsVEsHLc+LYPttpocptLhDaApPphsFHsLLRPpDaRpphcs....LppLLspu.pSsp......LpAAAsLLpspQpD-RLLQhsLNLLHKV........................	2	2	4	5
+9307	PF09475	Dot_icm_IcmQ	dot_icm_IcmQ; 	Dot/Icm secretion system protein (dot_icm_IcmQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are the IcmQ component of Dot/Icm secretion systems, as found in the obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii. While this system resembles type IV secretion systems and has been called a form of type IV, the literature now seems to favour calling this the Dot/Icm system. This protein was shown to be essential for translocation.	25.00	25.00	27.00	140.90	18.10	16.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.10	0.71	-5.04	21	62	2009-01-15 18:05:59	2007-05-02 16:43:40	5	1	51	3	3	55	3	178.20	57	91.04	CHANGED	AILKALD-AIEpGPWEESNFLRVIGKNL+EIR-sFuspluss..sptps+ptoph.AsRlALRoGQQElFIuLYSo-GsNlQoWERIlANLPRQMISRPIYAsEpDV+slIKoKENKlNEAYVAIYIsQsDILslssDKsPhDKhGKPLLoLKD+ulsLENIsRFVHhSGlY+Ys+GR...LlKs	..ILKALs-AIcpGPW-cSNFLRVIGKpLhtIRDpFhcpluus..sps..cl+.s-.upL.ANRlALRSGQQElaVSLYSSDGoNLQSWE+IlusLPRQMISRPIYA-E-DlKsllKoKENK.NEAYVAIYIsQoDILplosDKsPsDKLG+PLLTLKD+oIsLENIoRFVHlSGVY+YspGRLIKp.......	0	2	2	3
+9308	PF09476	Pilus_CpaD	pilus_cpaD; Pilus_cpaD; 	Pilus biogenesis CpaD protein (pilus_cpaD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry consist of a pilus biogenesis protein, CpaD, from Caulobacter, and homologues in other bacteria, including three in the root nodule bacterium Bradyrhizobium japonicum. The molecular function of the homologues is not known.	30.10	30.10	30.50	30.80	29.30	30.00	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.32	0.71	-4.84	38	190	2009-01-15 18:05:59	2007-05-02 16:43:56	5	2	168	0	79	185	16	181.00	27	84.57	CHANGED	hllshshsLuuCsssss.......t..spshcppHPIsVpcsspslsl.lssstsuLossp+spltuahppatppussslhlpsPu.ss.st.s..Assshp-lpphLtptGlssspltstshtsssspssuslRlsas+hsA.psssCGtWscshs.sh.....hcNpsh.NaGCAspsNLAAMVANPpDLlpsRshosssssR.Rspsl...-pYRpu	............................h..hhhshhLuuCstt.............s..shptp+slslppsppslpl.lt.ttttLsssppspltshhtphhp..t..usshlhl.h....Ps.st.....t..utpshtpltphlsttGlsspplhhts.....st........s.t........ssu......s.lRlsa.phpA.hs.s.sCu.thspc..hs.ss..........hpNcshhNFGCAspsNLAAMlAsPtDLltPRsh.sssDusp.pssslcpYRp...............	0	21	40	55
+9309	PF09477	Type_III_YscG	type_III_yscG; Type_III_yscG; 	Bacterial type II secretion system chaperone protein (type_III_yscG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	YscG is a molecular chaperone for YscE, where both are part of the type III secretion system that in Yersinia is designated Ysc (Yersinia secretion). The secretion system delivers effector proteins, designated Yops (Yersinia outer proteins), in Yersinia. This entry consists of YscG from Yersinia and functionally equivalent type III secretion proteins in other species: e.g. AscG in Aeromonas and LscG in Photorhabdus luminescens.	26.10	26.10	26.30	44.40	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.45	0.71	-4.01	7	84	2009-01-15 18:05:59	2007-05-03 10:10:21	5	1	65	4	9	55	1	110.50	55	99.54	CHANGED	MphpL+t.LAElALhGoGpHpHpEAssIA-WLtppsp.pEsVsLIRlSSLMNpGcYppA..L..stshshPDLEPWhALCEa+LGLtutL-pRLstLuuSusPplpsFssGhRpQlps	MchcLpp.LAElALhGTGpHCHpEAssIA-WLcttuc..-EsVpLIRlSSLMNRGcYppA..Lt.utppsaPDLEPWhALCEa+LGLtuAL-sRLttLutpts.t.tsFssuhpppl+s...............	0	1	3	4
+9310	PF09478	CBM49		Carbohydrate binding domain CBM49	Mistry J, Urbanowicz B	anon	Pfam-B_6310 (release 21.0)	Domain	This domain is found at the C terminal of cellulases and in vitro binding studies have shown it to binds to crystalline cellulose [1].	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.82	0.72	-3.88	28	310	2012-10-01 21:34:18	2007-05-03 10:13:48	5	20	40	0	245	346	0	82.10	25	20.10	CHANGED	lslpQplTuoWhsssp.sY.hpassslsNpu...spslpslplpls.pl.....ssIWGlsp..usssYshPuWls...oLssGpohsFsYIp....s	..............................tlppphhsoWh...p...s...sp...sa.hpaslplpNpu...spslps....l......plshs...slt............sslWs..ls......p.....ss.....s.......t..........a....s....L...P..u..aht....sls.s.Gp.oa.s.FGYI..ps.................	1	165	230	238
+9311	PF09479	Flg_new	flg_new; 	Listeria-Bacteroides repeat domain (List_Bact_rpt)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This model describes a conserved core region of about 43 residues, which occurs in at least two families of tandem repeats. These include 78-residue repeats which occur from 2 to 15 times in some proteins of Bacteroides forsythus ATCC 43037, and 70-residue repeats found in families of internalins of Listeria species. Single copies are found in proteins of Fibrobacter succinogenes, Geobacter sulfurreducens, and a few other bacteria.	20.70	14.00	20.70	14.00	20.60	13.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-8.25	0.72	-3.92	74	3687	2009-01-15 18:05:59	2007-05-03 10:35:46	5	395	401	4	433	3605	541	42.10	41	10.26	CHANGED	PT..+...sG.YoFsG.WYssp.ssGspasas..ssh...spslTLYApastss	.............Ps...K....pG..YTFpG.W...Y.....s..s....p....ss........G.......s....c......a....sFu............Tshh.........ssss....l....T........LYApashs.s...........................	0	247	380	413
+9312	PF09480	PrgH		Type III secretion system protein PrgH-EprH (PrgH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	In Salmonella, the gene encoding this protein is part of a four-gene operon PrgHIJK, while in other organisms it is found in type III secretion operons. PrgH has been shown to be required for type III secretion and is a structural component of the needle complex, which is the core component of type III secretion systems.	20.40	20.40	20.40	21.90	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.93	0.70	-5.60	8	407	2009-01-15 18:05:59	2007-05-03 11:43:20	5	1	334	38	14	205	0	296.60	47	95.75	CHANGED	hhlRlLsGPLpGsEahL.sGpsLhllGpssuhspsupss-........hPtsTlalPhspGssNFclhls..............tssschhLchLs-pssppc.lsaNpshpsGslthsl+.tsEsWpsp...................ssht.susspspsRhtsuhhsslsshhhLuslhshtlhhhsoppc.QltpLsslLssssppaplLsGcDGplYlLAsopRDusWu+QuLh+sphspsVplls.ssEppRIppaLscphPtLsha+LcLscPppPhLh.LS+pRsuhspsthc+L.ttLhshhPYAcslslsshsDssltppAcpGLschulsYcchscssuVTFlIpuuLsDsEltclppal-sah+pWGupYVpFuIpL+-DaL+GKSaphGssGYVhlssuHWYF	..............................................................................lGpssuLstSsths-..........lPtsohhlPhschsssFEI.ls.................................sssh.lhh+.ELpttpsEs...RolpLNp.IpVhtLhhhl+.csEsW..p...................PthlEss...hhpsc.+Fhsuhl.....hth.s..hh..FhLhhhhh.hthhhhsusp........c..phtplsplLstppptaplL.GcD.p.h.lYl.sp..c-slWs+QsLt+sp.sKssRVIN.s-EshR.I.oWLss.aPpLtYa+Lph.-spp.hhh.lS+Q...RNshopp.l-sL.ptLhthMPYAsslsIslhDDsshtuQA.tsLpt.uLsYp+hpptssVhFsI.GsLsDsEl.+hppaVDpYY+pWGtpYVpFslpLKsp.hpspSFpYGspt.a.K.psupWhF..................................	0	3	6	9
+9313	PF09481	CRISPR_Cse1	CRISPR_cse1; 	CRISPR-associated protein Cse1 (CRISPR_cse1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry, represented by CT1972 from Chlorobaculum tepidum, is found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse1.	21.90	21.90	22.30	22.30	21.00	21.80	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.69	0.70	-5.74	55	645	2009-01-15 18:05:59	2007-05-03 12:04:30	5	2	613	4	118	467	12	456.40	33	89.10	CHANGED	NLlc-PWIPVhht.....sGs..pt.plulpplh.....pssclhslshspPshpsAlhc..lLlul...lpss...............................tsP....cs.tc..cWtchapp...........shssctlpsaLpc..apcpFpLhssp...PFhQssth............pscstslsp...............Llh-h...suusshhhh.sahscpuhsph...ssupAAhsLlshpsausu...Gh+suhp...............GuGPlssls.sh...........tGpsLacTLhLNllstp..............thssss............hssWpts.spsspptspthh.........sshhphahhhsR+lcLh....spsst.............spsshhstGh...shsssh............h.t.cPhssa+............hppppshhshc...hpsuphhWRshsuLlhspssss....ptt........stllchhtphttpth..................................hplhshGhchDs.pA.ph.hphptshlslssth.........pppthtpplpphlptAcphtptLcstlpphhtst..............ps-hshhst.............tpaWppsEstFhp.hlpslst...........ttsppttttWpppl....pphuhpha-p	.........................................LLssPWlPVRhc...................DGs........ss.clu.h-L.......ss.cslhc.lAusRsDhp.sAsap..hLLulLQsu..............................................huP.....cc..h.....cpW.c-lWpc...........ulps-tlcchLts..h..c.ctFphss-s..ssFMQsh.................p.hpscp......sslus......................LLs-h......PGupssch...-ah..hc+Gssch.....hsspsuAlALaohQh.A.Puh.GtGh+o.GlR.....................GGGPhTTLltl............pt.s.s.Lac..pL....WLNVhsp-........tthshstphcst............lhPWhss...s...csuchsusshs..........ttsshlpsYashPRRIRlc.....tphpsGsss............................................hsstpsstLlshhhhcsaussa............hW.p.HPhTPaR...............h.hKpss....tahsl+....spPGuhhWRcahuLltsspscs..........spp...................AtVlchhsshsh.ppht....................................lsLhuhG.h-h-s.hcu.psa..h-c.chslL...............tpcshhsplctssp....sA.s.c.l.h.....s.h.L...Rs.Al+-shhus....................pss+uDhuhlch........................cFWspopt...pFhp.llcplcps...........pcsc.-.hlspWp+pl....hhhspp.F-.............................................................................................	0	34	85	102
+9314	PF09482	OrgA_MxiK		Bacterial type III secretion apparatus protein (OrgA_MxiK)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This protein is encoded by genes which are found in type III secretion operons, and has been shown to be essential for the invasion phenotype in Salmonella and a component of the secretion apparatus. The protein is known as OrgA in Salmonella due to its oxygen-dependent expression pattern in which low-oxygen levels up-regulate the gene. In Shigella the gene is called MxiK and has been shown to be essential for the proper assembly of the needle complex, which is the core component of type III secretion systems.	25.00	25.00	26.10	25.90	23.10	22.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.06	0.71	-4.64	7	353	2009-01-15 18:05:59	2007-05-03 12:05:50	5	1	334	0	15	157	0	136.90	46	92.30	CHANGED	lhplhacPloYlHssRhslssthhss.stRslsNchllstYcLss-ht....tsshhthalspWphLPplAhLhGsphhRspLsppGhhlpLsshspsFh.Ah.lssp.puu..pthss.ttll.......ssGhhpLluhhcphP.ultQRhsLLFPshh-cshs......hPstpsL.h.p.shpaAp+Hsph.ss	.................tlhhtPh.Yhp.ph...ss......s..t.hhN.hll.tapLp...s.t........ss.h.hhlppWphhP.hshh.GsphhRtthscpGhhhtlsshh..p..saL..u.h..ths..psp.....sths.s..p.ll.......ssGhupL.sh.c..P.uhtQRFsLLFPsFl.-chph.........hslt.ol..L..ls.h.htpphsphs.h........................	0	4	7	10
+9315	PF09483	HpaP		Type III secretion protein (HpaP)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are always found in type III secretion operons, although their function in the processes of secretion and virulence is unclear. Hpa stands for Hrp-associated gene, where Hrp stands for hypersensitivity response and virulence. see also PMID:18584024	23.30	23.30	25.40	25.40	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.24	0.71	-4.34	11	81	2012-10-01 19:58:36	2007-05-03 13:00:00	5	2	68	0	15	85	3	190.60	33	77.85	CHANGED	sPss....PA........cssppuhstsphhpsuhpsuPsspshPsps........h....sps.psAsss......sssPps.....pssscs.pstsDu.stpshutstsuc.......h.pspchsthlcplAtclAtFCussslhtuGp.WplplslDPslLPposLtLsLS.apLoLRF.....cosss-oRcLlspHtssL+tpLcs....thsusRslpI-Vs	........................................t...s.PA..........pupcpsF.hsphhpcu.h.ph.uPsstshPsss................h....spscc.sAsss......sssP.h........sstcs.ts..Ds.sptuhuRshAut....................htppp+hshhlctLAtclAtFCuusAlhsuGp.WEspLslDsplLPpTsLaLtLS.apLuLRF.....-sscs-oRcLLhsHpstLctpLcs....thusshsIpl-V..................	0	3	7	10
+9316	PF09484	Cas_TM1802	cas_TM1802; 	CRISPR-associated protein TM1802 (cas_TM1802)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This minor cas protein is found in at least five prokaryotic genomes: Methanosarcina mazei, Sulfurihydrogenibium azorense, Thermotoga maritima, Carboxydothermus hydrogenoformans, and Dictyoglomus thermophilum, the first of which is archaeal while the rest are bacterial.	22.50	22.50	23.10	23.40	22.00	22.40	hmmbuild  -o /dev/null HMM SEED	593	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-13.15	0.70	-6.03	16	118	2009-01-15 18:05:59	2007-05-03 13:06:51	5	2	108	0	59	118	6	501.70	18	87.54	CHANGED	MlpulhplGchhlp..scutpphph..........l.p.sptushtplLhlshsscpsplp..hhht-EhspcshpcaLahspussssu...hssTsphs.......................c.hcphtpKlpphhpph...h..............t+.c.hlp....................................................slcphlpcphcphlp-h.......shcppcsslholph...sschhhsp..aptahcthlpthppphh.....tKps+ppul.CplCscp.stlhuph.p...aKaYTsDK.sFss.shsppstaKshslCpcChhpL.tGcpalcppLssphh.uhc..halIPphlh........phcp.lccIhcphpphpshp......tslpppE--Ihphlpppcp...hhhshLF.acpsp..usa+IlhhIcDlsPSRhccIhcttc+spptht...................................phsLspIhhhh.......pp.spsspsKpaLplhsuIFsG+.lshchLlsphhptlRppah...............cstththhshpuhhlltFLpclshLp.......tshphcpspht.......pp-lcpFh....pphhpss.KpAlFLLGlLhscllphQa.........tcppsKsalsK..Lph.thsppclhplhs-lpsKLppY.......tt...ppY.hcplhtphtchhhpuhssWpLopDEhsFYhl.Ghohup	..................................................................................................hlt.h..lGp...t...t........................................ph.hhhhlth...tt.tth..........cpht.tpphtphh....a......httsss.ss...h...s..s.pht................................p..pth.thl.phhp.h...................................p.t.hhp....................................................ph.....phhtpt..hpphhpc..................t..tpp....h.hh.slth.......ssp....h.s....h..ahphh...ht.httt.........ttpt....tpth..CtlCspp.ptlhspht........apaaohD+.sahs.thp....ppphh..+shslCtpCh.tl.tGcpal.........pp.p.........L.phphh..uhp......hhllPphhh...........pp.ht..plh..pth..pphh..pht..........ph.t.cc..clhp.hp...p.pp.......h.hshlF.hpptp...st.+lhhhlpDV.PS+hpplh..pth.pp..hpphh.....................................phshttlh.hh...............tpt...p.h.Lp....lhpt....lhptp.lshphlhp..hhpth.....p..hh.......................pt...h.........hh...p.h.hhh.alpphshlp.....................t..h...t.......................p.hppah....tth.h.ss.cpu.hFLLGsLhstlhphQh................ppptspPhhpp..l.phht.hsppclhplhsclhsKlppY........pt......htth....hctl.htph..pphh...p..t.......t....pa.phs.pEh.FYhh.Ghsht...........................................................	1	23	43	53
+9317	PF09485	CRISPR_Cse2	CRISPR_cse2; 	CRISPR-associated protein Cse2 (CRISPR_cse2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family of proteins, represented by CT1973 from Chlorobaculum tepidum, is encoded by genes found in the CRISPR/Cas subtype Ecoli regions of many bacteria (most of which are mesophiles), and not in Archaea. It is designated Cse2.	22.10	22.10	23.40	22.80	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.94	0.71	-4.15	58	642	2009-01-15 18:05:59	2007-05-03 13:07:14	5	4	627	2	120	399	12	146.00	32	78.32	CHANGED	uspApLRRutshsss...........h..ha........hhp..h..t............ptpppshhhlAulhAttppt.....................................ps.ut.....slGpsht.hhttstt.............sss-tRFppLlpus..........hcplhppLRpllphlc..sp....lsaspLscsLhtWpppp..............ptlptcWupDYa	...........................................................Gt+AsLRRusssscs..........phscua.......Lhhpstp.hh.pt...............phc.hsAlsls..AulhAphcthcc...............................................................ppshus.......pLuts............................hsc.tRFs+Lhssc.........ss--LlcpLRRhVcLLs....us........lshssLA-slapWspcpp............s-hlRlRWAh-YY.................	0	34	87	105
+9318	PF09486	HrpB7		Bacterial type III secretion protein (HrpB7)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.89	0.71	-4.30	6	92	2012-10-01 21:16:01	2007-05-03 13:20:05	5	1	73	0	16	91	1	149.70	35	85.75	CHANGED	RRspsacsLlpt+sRcscRlpscLustRstLppssstLtpspspscApsscLssasuplDshsusGushsl-shLppccaRssLh-pputAEpttstAptuLputtspluuhppcluR.cApl-lhs-+tcplcRAt-AttEsAp-EEs.EAlluhRh	...............cpttsapsLhth+spctcRhptclpshRtthptstttlspsptpsctppsthsthstplsshss.ssushs..lsshhtpccaRssLh-cpttAEpppAthcsslputtcpluuspppluR.pApl-lsc-+hcplcRut-AttEsAp-EEh.EullAtRh............	0	3	6	10
+9319	PF09487	HrpB2		Bacterial type III secretion protein (HrpB2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow group of species including Xanthomonas, Burkholderia and Ralstonia.	25.00	25.00	51.70	51.20	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.47	0.71	-3.90	9	93	2009-01-15 18:05:59	2007-05-03 13:24:07	5	1	73	0	16	60	1	116.90	38	89.29	CHANGED	ussosAhsPsss.....sstpLss+FpALMpsusshPsuhptscs.Shlu+lVtppDsulRpsssclthhsppAsphohp-l..sAtslclphEhsuhphchpsphuVspSuKsAlpTLMKNQ	............................hss.AhsssAs.....sstcLssRFpALMpsAsstPsttppsts.Sslu+lVsspDstlRpss-clsshshpAsphohpEh..sApsl+lphElsuhphchpsphuVspSuKsAlpTLMKNQ	0	3	7	10
+9320	PF09488	Osmo_MPGsynth	osmo_MPGsynth; 	Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of examples of mannosyl-3-phosphoglycerate synthase (MPGS), which together with mannosyl-3-phosphoglycerate phosphatase (MPGP) EC:2.4.1.217, comprises a two-step pathway for mannosylglycerate biosynthesis. Mannosylglycerate is a compatible solute that tends to be restricted to extreme thermophiles of archaea and bacteria. Note that in Rhodothermus marinus, this pathway is one of two; the other is condensation of GDP-mannose with D-glycerate by mannosylglycerate synthase.	20.20	20.20	21.50	127.70	19.30	18.70	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.23	0.70	-5.78	15	56	2009-01-15 18:05:59	2007-05-03 13:38:18	5	4	53	12	32	53	9	385.70	44	87.68	CHANGED	lEhPp.sEpFGuVpIH.-VQ+VlE..LDoG........s.ttpssslpslspccLpclhpchAIVVPsKsEcl+LLEGVLpGIPH-ChlIlVSNSpRps.hDca+hEh-hlcpFsphTc+pllllHQKDPsLApAFp-sGYsslLsscuh.....VRsGKuEGMIlGhLLAKh..hG+cYlGFlDADNYlPGAVpEYV+tYAAGFsMu..............cSPYoMVRlpW+aKPKVscss.lYFcKaGRVSElTN+aLNtLlSshouFET-..........lIpTGNAGEHAMohcLAcpLsauoGYulEPYchV.LLEcFGshhts.tps-shppG..................................................lEIhQIEThNPHlHE.-KGs-H.lpcMlhsSLusIYH..................................S+Lss.........ctl+pcILc-L.....ptpshlspt.--PPpPhlhPPltplDlctFtchlc	........................h.EhPphsEhFGsVcIa.-lQ+Vlc..LDos...............sttsts.slpslsppslpcllpchAIVVPhKsEcL+Ll-GVLpuIPHcChIIlVSNSpRt...-pa+hEhDhlccFsphTc+phlhlHQKDPuLApAFpcsGYsclLs.csGh...........VRsGKuEGMllGllLA+h..hG+cYVGFlDADNYlPGAVpEYl+sYAAGFtMu...................cosYoMVRlpW+aKPKlspsp..laF++aGRVSElTN+aLNpLloshouFE..Ts........................llpTGNAGEHAMohcLA.hLsauoGYulEPachV.LLEpaGthhs...ttp-shppG..................................................VEIhQIEThNPHhHE.sKGc-H.lccMlhsuLuoIYH..................................ScLss.........-pl+pclLc-L.....ptp..shlpps.cEPPpPhlhPPlpplDlctFhchl.............	1	7	18	24
+9321	PF09489	CbtB		Probable cobalt transporter subunit (CbtB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of a single transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localisation with a protein (CbtA) predicted to have five additional transmembrane segments.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.92	0.72	-4.06	20	220	2009-01-15 18:05:59	2007-05-03 14:19:16	5	1	217	0	69	157	46	56.40	39	87.85	CHANGED	sspsssssspu.sclhtssuAshLGhsllahsGFuphsslHNAAHDsRHusuFPCH	........................................hs...t.shshs.tplssulsuhlL..G...shL...lYhsG........aup.......s.......sh........lHsuAHDsRH.u.hG.FP.CH	0	12	37	53
+9322	PF09490	CbtA		Probable cobalt transporter subunit (CbtA)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of proteins which have been proposed to act as cobalt transporters acting in concert with vitamin B12 biosynthesis systems. Evidence for this assignment includes 1) prediction of five transmembrane segments, 2) positional gene linkage with known B12 biosynthesis genes, 3) upstream proximity of B12 transcriptional regulatory sites, 4) the absence of other known cobalt import systems and 5) the obligate co-localisation with a small protein (CbtB) having a single additional transmembrane segment and a C-terminal histidine-rich motif likely to be a metal-binding site.	22.20	22.20	22.70	24.30	21.40	22.00	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.60	0.70	-5.04	25	417	2009-01-15 18:05:59	2007-05-03 14:20:37	5	1	375	0	137	384	69	223.70	30	92.26	CHANGED	Mhp+llhuAlhAGllAGllsshLQhhhlpPlILcAEsYEsush...................sH.tupu................................suuHs..Hstt......s.ht.tsGhp....RshhT....hsuNllsusGaA.LlLsuhhult.t...stsssppGLlWGlAGFsuhpLAPulGLPPElPGssAAD.............................LssRQhWWluTlsuTAlulsLlAFupshhhhhlullLllsPHllGAPp........P-shsussPspLuspFssAuhssuhshWssLGlluuahapR	................................................MhtpllhpuhhAGllAGlLshshthlhspPh...l.pA.saEputs.......................pttutu...............................huscs...ct...............tstcshp....................Rssts....hhusllhusuh....u..Lhhssh.sh.h....h....s........th....ss....ttt.u.l....hhuhuGFhslhllPsLthPsp.Pu..sus.s.-.................................L.s.tR..h...h....Whu.....o.l......s.......u..s...u..h....u...lh.....l...........l.............................................................h.....h.........h.u....l.........s....h...l....l....h...P...p......l.....ht.....s.....Pp............t...h..s.shPusLhhpFtlASlusphlhWsslGLshGhhhp...............................................................	0	27	74	108
+9323	PF09491	RE_AlwI		AlwI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the AlwI (recognises GGATC), Bsp6I (recognises GC^NGC) , BstNBI (recognises GASTC), PleI(recognises GAGTC) and MlyI (recognises GAGTC) restriction endonucleases.	19.70	19.70	20.00	19.90	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.48	0.70	-6.00	18	173	2012-10-11 20:44:45	2007-05-03 14:23:23	5	4	152	2	21	155	34	374.30	18	73.57	CHANGED	pplGFlhhc.........t...thlplTcsG+tLls..................p...s.pplFL+pLlKaQlssshppp..........h.hpPahhlLcllpcL...........stlohcEhshalhhhhs...ppphcpllsc..........IhpaRppchttpt....................scchapccphpt..................................ptuhcpphcspt.............................................................shpDYsDsshRah+hTGlhshp....upG+hlplsppcp.cpl-hllpshpp....h......s.ppahphhspsststLsh-......shtpphlpplsthhsphspphtltpht..h...........shsp-plccplpclpc......pKhhpc..........hhplLp.htch.pt................tptPshhEahhhhuhh.tlssththh....NhphDs-shPhssAsG..stsDI.h.......ascathllEVTLscuppQp...phEupPVsRHlschtpch.....scshaslFlAPpIcssohppFhht.h.........t.ttthtIhPhslppFhph	................................................hGhh..t...................h..lot.Gphhlp.....................ph.p.haLptlhphphsssh................h.Phhh..llplltch...........t.l.shc-h.hhhhhh........ppphptlhpp..........IhphRpph.t...p.........................pp.h.pt.ht..............................................................................tp.hph.t.......................................................................................................hp-h.D...hRhhphTslhph.......t.sphh..h....t....hp.l.lpphtt.................h....t......l.hp...........h.......p...................................ph..p.h.p.h..hhp......tp..pp..........hhphl...................................t.P.hhhEah.hhhhh..h.t..........shph-sphhPh.pAsG.......s......sDl.h.........tph..hlEsoh.ptppQ....thEh.sl.RHh..hphh.p........h..hslFlAs.lptsshp.h.....................thtIhshth.ph...h...........................................................................................................................................................................................................	0	7	17	18
+9324	PF09492	Pec_lyase	pec_lyase; 	Pectic acid lyase	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are isozymes of pectate lyase (EC:4.2.2.2), also called polygalacturonic transeliminase and alpha-1,4-D-endopolygalacturonic acid lyase.	19.80	19.80	19.80	20.10	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.00	0.70	-5.24	51	198	2012-10-03 02:33:51	2007-05-03 14:24:54	5	14	122	5	65	232	27	282.70	34	61.02	CHANGED	QpssGGWsKN......hDhstshsttpttth...............httttp...puTIDNsATssplpaLA+lapts........pst...+a+sAhh+Gl-aLLsAQYs.NGGWPQ...................aYPh.ppu.......YpsaITaNDsAMlsVlplLc-lupspssa.t..hls.psppt+uppAlp+Gl-sIL+sQl.h...sGp..hTsWsAQHDppTLpPstARuYE.sSLousESsuIlcaLMsl.pPo...scllpAlcuAlsWhc..ps+lsGh+h.phts............p.hhltc..susslWARFY-lsTN...................+PlFssRDuh.......h+asls-lptERRsGYuWasshspcll	..................................QpssGGWsKs.......hchssthstpphtph.....................hptttph....puTlDNsATssplpaLuclYpto........psp.......+Y+sAhh+GlcaLL.puQYs....N......GGWPQ............................haPh.tts.........................YpspITaND.s.AMsp..lhplLpplhpt.pssat.................hls.tthp....t+...sppAhs+Gl-sILcsQlh....s..Gp...hTsW.stQaDph.TL......pPstARuYEhsSluusESssllphLMslspPo...sclhpulcuAlpWhc..ps+lpGhphpphts.............t.hhl.........s..susslWARFY-lpTs...............................................................+PhFscRDG.h........hphs.ltclstERRsGYuWYss.stpl.........................................................	0	34	57	62
+9325	PF09493	DUF2389	CHP02450_Tryp; 	Tryptophan-rich protein (DUF2389)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are small hypothetical proteins of 60 to 100 residues from Cyanobacteria and some Proteobacteria. Prochlorococcus marinus strains have two members, other species one only. Interestingly, of the eight most conserved residues, four are aromatic and three are invariant tryptophans. It appears all species that encode this protein can synthesise tryptophan de novo.	25.00	25.00	32.30	32.20	21.00	16.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.12	0.72	-3.70	57	214	2009-01-15 18:05:59	2007-05-03 14:45:43	5	3	201	0	79	203	221	60.10	36	70.83	CHANGED	sSKWTuspshs.tp+HFhlsphthcc.ctphlc..hlpsl.scpphplsWp-L+ssspWppGWp	.h.SKWTAspshs.tp+HFhVsphp.....tcc.....csshlc..hlpul.spp....phhlsWpp.L+DsshWptGWp.	0	15	45	65
+9326	PF09494	Slx4		Slx4 endonuclease	Wood V, Coggill P	anon	Wood, V	Domain	The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals.  Slx4 with Slx1 acts as a nuclease on branched DNA substrates, particularly simple-Y, 5'-flap, or replication fork structures by cleaving the strand bearing the 5' non-homologous arm at the branch junction and thus generating ligatable nicked products from 5'-flap or replication fork substrates [1].	21.30	21.30	21.40	23.30	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.11	0.72	-4.22	57	215	2009-01-15 18:05:59	2007-05-03 15:16:06	5	8	193	0	153	225	0	65.60	27	7.08	CHANGED	lhptlpphlc.................ppPs....hac+ILhY-PItLc-LtshLp....tth....clststl+pahDppuIshphp	..........................................................hptlpphlp.................spPs....hac+ILhY-........PI.Lp-LtshLp.............ssl.....clshspl+cahDspsIshph.t................	0	39	67	117
+9327	PF09495	DUF2462	UPF0390;	Protein of unknown function (DUF2462)	Wood V, Coggill P	anon	Wood V	Family	This protein is highly conserved, but its function is unknown. It can be isolated from HeLa cell nucleoli and is found to be homologous with Leydig cell tumour protein whose function is unknown [1, supplementary Table I].	21.80	21.80	23.00	22.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.85	0.72	-3.25	16	199	2009-01-15 18:05:59	2007-05-03 15:21:16	5	6	183	0	143	182	0	80.70	31	76.49	CHANGED	MAQGthKh..KAKsssssp........+Kpps.++.usRhItPKKtshhptpKLpKhhouulpspsE+.lsp+A.....G+LpLlK...usp+cp	........................MAQGph.K...........Ku+tssssp.........tpppp..u.s..+K.Gs+sIt.PKKs.p..l.h.p.p.pK.lp....Kplosulsp.psE+tlsp+A.....G+LpLlK...ustc..h...................	0	41	69	114
+9328	PF09496	CENP-O	Cenp-O;	Cenp-O kinetochore centromere component	Wood V, Coggill P	anon	Wood V	Family	This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere.  It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human [1][2].	19.60	19.60	19.80	20.00	19.00	18.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.03	0.72	-3.75	28	202	2009-01-15 18:05:59	2007-05-03 15:21:40	5	1	164	2	135	187	0	88.50	31	28.93	CHANGED	LGlRh-lhsc.pupFhcPYYllL++hsp.tp.....................hpla+HTlPsaIPlcpltpph.Lss.............................tpp-lppFscclpcpLssaphRpcthptL	.........lGlph-l.st.pGpahcsYYllLpp.pt..tt.......................................lpla+HTlPsFI..PLcpltpca.Lss......................................slppFlcplpcpLsuaptR+tthp.L...........	0	25	60	100
+9329	PF09497	Med12		Transcription mediator complex subunit Med12	Wood V, Coggill P	anon	Wood V	Domain	Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator [2].	25.00	25.00	29.80	25.00	24.90	19.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.07	0.72	-3.99	28	294	2009-01-15 18:05:59	2007-05-03 15:21:57	5	9	223	0	201	300	0	62.60	40	3.55	CHANGED	sFp.PsRVTLocs++-sWLp-LAssshsLpcLu+p.lPHGh+p+pLl-thh.............................................ppplPlpRAlWhlK	..............Fh...hsshopsphcsWhpDLAs.stPLppL......u+...........p.lPph....++cplhshlh.............................................phsVPlhRAsWLlK..	0	54	94	155
+9330	PF09498	DUF2388	CHP02448; 	Protein of unknown function (DUF2388)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of small hypothetical proteins, about 100 amino acids in length. The family includes five members (three in tandem) in Pseudomonas aeruginosa PAO1 and in Pseudomonas putida (strain KT2440), four in Pseudomonas syringae DC3000, and single members in several other Proteobacteria. The function is unknown.	25.00	25.00	26.60	31.10	19.30	18.80	hmmbuild  --amino -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.29	0.72	-4.34	32	301	2009-09-10 15:05:37	2007-05-03 15:32:04	5	1	84	0	73	218	5	71.80	49	68.29	CHANGED	ulssSstsTossoooh+.DpKlVlsARDDAAoFVASsGsIRGApLEAALpplRpptPpL.pASDhpLApAILuh	...........................s.hhposssTSssoooh+.DsKllhsARDDAASFVASsGsIRGApLEAALpplRppsPph.pASDhpLApAILA.h..	0	7	14	47
+9331	PF09499	RE_ApaLI		ApaLI-like restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes R.ApaLI and R.XbaI restriction endonucleases. ApaLI recognises and cleaves the sequence GTGCAC.	25.00	25.00	26.30	25.90	22.80	20.20	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.25	0.71	-4.92	6	327	2012-10-11 20:44:45	2007-05-03 15:36:43	5	1	171	0	9	42	2	56.80	51	84.36	CHANGED	slpcpI+hLAppYAscLpppltpRshEMpsDDp.................................................SHYLIY...........RVLGlsh-EGcLIDhYQNpGRFLYKYAGSFLEE..AThLCFKctF........................scu..u+t+VtNTpGp+PKsFEIDCLl.....sspAaEIKWR..DATTDGDHIsKEHTRl+VlpstGYhPlRIMFYYPsRsQAhRIQpTLcTLYpGVGGpYYhGDuAWsaVcccTu	..................................................................................................................................................................................................................................................................................................................................................................	0	6	9	9
+9332	PF09500	YiiD_Cterm	yiiD_Cterm; 	Putative thioesterase (yiiD_Cterm)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry consists of a broadly distributed uncharacterised domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain Pfam:PF00583.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.80	0.71	-4.62	47	840	2012-10-02 20:54:35	2007-05-03 15:37:05	5	5	832	4	122	505	74	141.30	61	49.49	CHANGED	tppLpphh+ppIPloctMulplhpasspplplsAPLssNlNh+sThFuGSlaoluTLoGWGhlaLpL+-tslp.GcIVlt-upIcYhtPlssc..hApsphs...................shss.lspLpptp+ARlplpsplhsssph.......supFpGpaVsh.	........................CuQLQQAWY-HIPLSEKMGVRI....QQY..T.GQ+FlTTMPE.s...G...N.Q.NPHHTl..........FAGSLFSLA.TL.TG.WGL.IW.Lh.L.RERHLG....G........TI..I..L.A.D.AHIRYS+PIoG+...PpAVADLu...................uLSGDLDRLAR.GR..K.ARV.QhpV-la.G.sE.ss.......GAlFEGsYlVL.P...............................	0	22	48	86
+9333	PF09501	Bac_small_YrzI	Bac_small_yrzI; 	Probable sporulation protein (Bac_small_yrzI)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are very small proteins, about 47 residues each, in the genus Bacillus. Single members are found in Bacillus subtilis and Bacillus halodurans, while arrays of six members in tandem are found in Bacillus cereus and Bacillus anthracis. An EIxxE motif present in most members of this family resembles cleavage sites by the germination protease GPR in a number of small acid-soluble spore proteins (SASP). A role in sporulation is possible.	21.20	21.20	21.90	21.40	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-8.07	0.72	-4.05	13	422	2009-01-15 18:05:59	2007-05-03 15:43:11	5	1	124	0	34	156	0	46.00	49	98.60	CHANGED	MTFplFFLTITIQK+p...hSpsElcpcpQhcplh-Eh+-Rp..spYhs+h	.MpF+lFFLTITIQKpp...lSpsEIh+-pQIcphMD-lKERQ..upYho+L.........	0	4	21	22
+9334	PF09502	HrpB4		Bacterial type III secretion protein (HrpB4)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.	21.60	21.60	21.80	55.80	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.56	0.70	-5.15	8	89	2009-01-15 18:05:59	2007-05-03 15:43:34	5	1	71	0	15	75	1	211.40	37	94.56	CHANGED	ssApstthARhLpcapsplssLs-alD....s.uWLpsssulus...u+usuhRsthphh.......h.+sh.shtGhssPoLssL-stAsR.................LAVLstssLlpVLpuRALhsRsssLRpCI-RspRotLpptlGPtsh.hh.s.tt....-AsptcsustuhsPL......sh-ucshAWl..GaRthppDGsWPssu.lh+llRLAL...Ptu.........u.sPpLsPhAusu...sucphLuALPoLaPE	...........................s.ss.hpttAthLptapsshtphschlc....s.uWhs.sls.uls.....upAsshRsAhphh..........h.csl.....Ghu...tsolsuLtthA.s.R....................LAlLshsphh+VLthRALhhRpstlR+sIDRtphs+LtshV.......Gssssphh...................-AsRtp.......tpst.....shsPL.....sth-A..cslAat..GWphhpsD..ss....hsss...........u.sh..+...llRLuL...Ptu.............s.ssh.LsthA.ucs..............sutthlstLPoLhPE...	0	3	7	10
+9336	PF09504	RE_Bsp6I		Bsp6I restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the Bsp6I (recognises and cleaves GC^NGC) restriction endonucleases.	25.00	25.00	29.40	71.10	21.00	24.90	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.21	0.71	-4.82	3	17	2012-10-11 20:44:45	2007-05-03 16:24:33	5	1	17	0	0	10	19	169.30	53	94.55	CHANGED	MAYKKFGYIEIDDARI--TCDAYFKWKDLNoYIKNTSSRGINMPDAISEPMGCYCLGYLWNRGoEVGDATDPcTNAKIEFKATSKFDGDLSSFGPKTVFDNLVFLRFNLD-NcLYIYDLsINSE-LcKYPANKTQTIQDQKAhGRRPHVSLQKLFVEA+DlcPDIIFDIRRCRIIEDNR+	.....uDsh...........DKs-FEhlp-lahcWhhhNp+lKSluuRGlNhPDVFSEuLhChAhNhlRosGTuh.hDslhcDTsctVQVKuuS.hssDsTSFGPTSsaDlLYFAcFs.ssc.-hhVhhhKIpsDDlYNlslN..KsETFKDQQAQGRRPRFSIQSsII+uKcLhPltslNI...........ITGc.......................	0	0	0	0
+9337	PF09505	Dimeth_Pyl		Dimethylamine methyltransferase (Dimeth_PyL)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of dimethylamine methyltransferases from the genus Methanosarcina. It is found in three nearly identical copies in each of Methanosarcina acetivorans, Methanosarcina barkeri, and Methanosarcina mazei. It is one of a suite of three non-homologous enzymes with a critical UAG-encoded pyrrolysine residue in these species (along with trimethylamine methyltransferase and monomethylamine methyltransferase). It demethylates dimethylamine, leaving monomethylamine, and methylates the prosthetic group of the small corrinoid protein MtbC. The methyl group is then transferred by methylcorrinoid:coenzyme M methyltransferase to coenzyme M. Note that the pyrrolysine residue is variously translated as K or X, or as a stop codon that truncates the sequence.	25.00	25.00	529.60	529.50	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	466	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.64	0.70	-6.22	3	16	2009-09-13 14:57:56	2007-05-03 16:31:52	5	1	8	0	12	25	14	459.20	77	99.76	CHANGED	MATEYALRMGDGKRIYLTKEKIluEIEAGoANAADLGEIPALSuDEM-KLAEILMMPGKAVSVEQGMEVPVTHDIGTIRLDGDQGNSGVGIPSSRLVGCMTHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKAFKIsEAWESMEHAADHLTRDTVWVMQKLFASGADGVNFDTTAAAGDGDMYGTLHAVEALRKEFP-MYIEVGMAGEMVLGMHGNLQYDGVTLAGLWPHQQAPLVAKAGANVFGPVVNTNTSKTSAWNLARAVTFIKEAVKASPIPCHVDMGMGVGGIPMLETPPIDAVTRASKAMVEVAGVDGIXIGVGDPLGMPISHIMASGMTGIRAAGDLVARMEFSKNMRIGEAKEYVAKKLsVDsMDLADEHVMRELREELDIGVITSVPGAAKGIAAKMNIEKLLDIKINSCELFRKQl	.....MATEYsLRMGDGKRlahoK-+Ihp-lEAGhusAuDLG-IPsLSs-Eh-KLAEILMMPGKsVSVEQGMEVPVTHDIGTlRLDGDQGNSGVGIPSSRLVGCMhHERAFGADTMELGHIDYSFKPVKPVVSNECQAMEVCQQNMIIPLFYGAMPNMGLYYTPDGPFENPGDLMKtFKIpEAhESMEHAA-HLTRDTVWVMQKLFASGADGVNFDTTuAAGDGDMYGTL+AIEALRKEFP-MYIEAGMAGEhVLGMHGsLpYDGVTLAGLWPHQQAPLlAKAGANVFGPVCNTNTSKTSuWNLARAVTFhKAAVcASsIPCHVsMGMGVGGIPMLETPPIDAVTRASKAMVEIAGVDGIOIGVGDPhGMPISHIMASGMTGhRAAGDLVARMpFSKNMRIsEAKEYVAKKLsV-hMDLuDEaVMRELREELDIGlITSVPGAAKGIAAKMNIEKLLDIKINSCpLFRKQl..	0	4	7	7
+9338	PF09506	Salt_tol_Pase		Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase)	TIGRFAMs,Coggill P	anon	TIGRFAMs	Family	Proteins in this family are glucosylglycerol-phosphate phosphatases, with the gene symbol stpA (Salt Tolerance Protein A). A motif characteristic of acid phosphatases is found, but otherwise this family shows little sequence similarity to other phosphatases. This enzyme acts on the glucosylglycerol phosphate, product of glucosylglycerol phosphate synthase and immediate precursor of the osmoprotectant glucosylglycerol.	25.00	25.00	248.60	248.30	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.17	0.70	-5.91	16	45	2009-09-11 09:42:30	2007-05-03 16:32:15	5	1	45	0	16	45	195	380.80	52	93.38	CHANGED	pcLLIVQDLDGVCMPLVKDPLTRpl-scYVpAsupLpscFsVLTNGEHEG+RGVNRlVEpALuspppspccGLYLPGLAAGGVQaQDRaGplSHPGVS-sElsFLAtlPp+McshLtppLsslhPpLoscplpphhptAlLDTplSPTINLNuLFull.sDVppQ+pLQthlpclMspLlspApupGLcsSFFLHlAPNLGpctsGpEhlK.AstsDlGTTDIQFML+GAlKEAGLLsLlN+aIup+oGpuPLG-sFNVRsAP+sHpuLLsLC+cpIss-pMPhLVGVGDTVTSph..sssupuWLRGGSDRGFLTLlQcLGppaspsNRVVhVDSSpGEV.sRPSlpDssLpGIS..........DP-DPL+FDllhsuGPcpYlsWFppLAp	.pNLLIlQDLDGVCMsLVKDPLTRpl-scYVpAspphpscFhVLTNGEHtG+RGVNRlVEpALGssshsppcGLYLPGLAAGGVQaQDRaGplSHPGVScsElsFLAtVPpthcstLpphlsshhPpLus-plpptlptoVLDspsSPTlNLNuLFsllpc........-sphhppLQphhppLMspLltcAtupGLtsSFFLHlAPNLG+Dpp...GpEhlK.AptsDsGTTDhQFML+GAlKEAGlLsLLN+ahtpRTGphPLGcsFNsRsAPpsHpsLLcLs+pplsscpMPhlVGVGDTVTSps...ss..s..stsahRGGSDRuFLpLlQcLGptaspsNpVVaVDSSpGEV.sRPslphss...........l.pGIo.................Ds-DPL+hslshPsGPcpYlsaFpplA.....	0	2	8	14
+9339	PF09508	Lact_bio_phlase	CHP02336; 	Lacto-N-biose phosphorylase	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The gene which codes for this protein in gut-bacteria is located in a novel putative operon for galactose metabolism. The protein appears to be a carbohydrate-processing phosphorolytic enzyme (EC:2.4.1.211), unlike either glycoside hydrolases or glycoside lyase. Intestinal colonisation by bifidobacteria is important for human health, especially in pediatrics, because colonisation seems to prevent infection by some pathogenic bacteria that cause diarrhoea or other illnesses. The operon seems to be involved in intestinal colonisation by bifidobacteria mediated by metabolism of mucin sugars. In addition, it may also resolve the question of the nature of the bifidus factor in human milk as the lacto-N-biose structure found in milk oligosaccharides.	26.60	26.60	27.20	77.50	24.40	26.50	hmmbuild  -o /dev/null HMM SEED	716	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.52	0.70	-13.24	0.70	-6.87	7	288	2009-01-15 18:05:59	2007-05-03 16:33:53	5	3	255	18	27	215	17	673.60	54	98.37	CHANGED	GRhTlPs-sshtppshELhpRWGADAlRDsDGTchs--lhphssKlYSTYhssRsDpsWAptp.-ElpQhYLMop.ssAhS-sh.pIsLhcGaac-QhhsssspD.ccWWEVlDRTTupVlss-pWsaDtpstpVhlpsspsaHcYTVoFLAahIWDPlpMYNalTNsWtshcHph...saDshpPcTppalhpthccWlc-pPpsDVVRFTTFFapFTLsaspht+E+aV..DWaGYusoVSPhALEpFEKEhGY+LpPEDhlDpGaYNssaRVPsKpa+DahsF.pcaVschsKcLV-lsHpsGKEAMMFLGDpWIGTEPatctFpclGlDAVVGSVGsGsThRhIuDIPGV+YTEGRFLPYFFP......DsFhEGGDPlhEApsNWlpARRAILRpPlDRIGYGGYLpLAspFP-FlDhlEcIssEFRcla-shpGppsh.shh+VAVLNsWGphRSWtsphVtHAlah....+psYSYhG..llEuLSGhPh-VcFISFDDIhcp.Gl.c-lcVlINsGsusTAaSGGphW.c-tclsutl+pFVtpGGGhIGVG-P.oAppapG+aaQLAcVLGV-+EhGholSpc+Yshphp.pHFlT.t-hstc..............................lDFGEuhpslYshss.splLttc...........ttplphAVNpaGcGRuVYluGlPYShcNuRlLhRulhWAuppEpphppahSoNhpsEVAhYscss+hsllNNT.-.QpTslhps.ucs.slcLts.-hhWhsl	.................................GRlTLPs-psh.tpstELh-RhtADAlRsSDGTcLP-.lpcL.s.sKIYsTYassRuDp-WAptHPcElpphYLMSchssAh......u-s..sIsLMpsaas-QltPsscsDsc+WWpVIDRTTG-VlssstWph-t..tst.s......V..slppAtshH.YTVuFLAh.hWDPspMYNalTNsWt.Dc..pcI...PaDlRpPpThpalhctLcpWLt-..sPpVDVVRFTTFFYpFTLlasppu...pE+..aV..DWFGYSASVSs.AlEtFEKchGYtLpsEDhlDpGaYNSsFRVPpKpa+DalsFQpcFVsphs+ELV-hsHtsG+EAMMFLGDpWIGTEPYG.tFtphGlDAVVGSVGsGsThRhISDIPGV+YTEGRhLPYFFP......DsF.a-GGDPV..tEApssWlsARRAIlRsPlDRIGYGGYLSLAhpaP-FVDhlEclssEFRpIassstGppPh.ssh+VAlLNsWGtlRSWtsaMVAHALaY....+QsYSYhG..lLEuLSGhPhpVcFlSFDDIhp..Glscsl-VlINsGsAsTAaSGGp.W.tDtclsoslRcFVtsGGGhlGVG-P.oAh....t..p..GthaQLuDVLGVD+EhGasLSsc+ash..........c..hsccHFlo.tDl.s..s..c..............................lDhGEGh..sl.ashsssTplLttc.......................cp.pVpLAsNpaGpGRuVYluGLPYS.pNuRLLhRAlhWAu+cE-th.pp.WhSosspsEVssYPcss+hhVlNNoh-t.sTsVhss.sss.pclchpssthhWhc............................	0	15	19	23
+9340	PF09507	CDC27		DNA polymerase subunit Cdc27	Wood V, Coggill P	anon	Wood V	Family	This protein forms the C subunit of DNA polymerase delta. It carries the essential residues for binding to the Pol1 subunit of polymerase alpha, from residues 293-332, which are characterised by the motif D--G--VT, referred to as the DPIM motif. The first 160 residues of the protein form the minimal domain for binding to the B subunit, Cdc1, of polymerase delta, the final 10 C-terminal residues, 362-372, being the DNA sliding clamp, PCNA, binding motif.	24.40	24.40	24.40	24.60	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	430	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.68	0.70	-5.25	21	329	2009-01-15 18:05:59	2007-05-03 16:34:30	5	7	232	7	213	324	1	344.60	20	88.93	CHANGED	+lVTY+hLScsLsVHsNpAKQMLY-ahcpcppcps.splaATYlloGp.hsst.sspp...................................................lslVcE-cLEss+u+hspshShalYSlQpshLpDsssLhsssh-hlpp.....spp.sthpstphs.htstplppppt......s.ssts....psshsuc.s...............stcsspuhhs.thpscppspspspp+sppstpscttss......pssstKh.s.s+ushhssFhptpsppKhttp.tstpsstpE.....ppt.psspshs.pcpss.......cppcps..hcs...................p.sspppppp.......................EscKc+.cc+l+phhpDc................s---............ss-SP.sppcspsssPs..........cp-.ptppsphpst..........s+RRtRR+V.hKpcThhD.-EGalVTcch.p.EShS-sEss.s................PsKppsssp.ss..ss...........spcsK.............sttttQusIMSFFpKK	...........................................................................................................................loa+.lu.thtlp.s.AK..p....h................L.pahpppp.............splpssYllpG..h.p.tt...............................................................................................................lhl..lp.-..p.pLpth..h...t.pht...h..o...hplYSl.....p..........s...h..p.-.......s......l.....h.....s....s....t...........ph.t................t......sh...t...tt.h..s.h....s...t..pptpt..................................sh.stt............................................t...pt....t.....t...p...pt.t...ps.p..ttp.ttp.....tttp...st.......................ps.s.t.c.......................tp..ss.h.tshhtttsh...ttht........t...tt.....tp.....................................p........t..h..p..p..........p.ttpt...t..............................................ppppppp........................................................................................cp.ppc......ccch..+..........p.ss...................................sp-p..................pp.......t....p....t.p.................................ptp........t.p................................ptt....t.+..+pl..hp..ppp..hhD.-c.G.hh.........VTpp.....t.ph..s.ppc..............................................p..tsh..t.........................................................t.t.p.......................................tt.t..Q.ss....lhuFFt+....................................................	0	66	111	175
+9341	PF09509	Hypoth_Ymh	Hypoth_ymh; 	Protein of unknown function (Hypoth_ymh)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry consists of a relatively rare prokaryotic protein family (about 8 occurrences per 200 genomes). Genes for members of this family appear to be associated variously with phage and plasmid regions, restriction system loci, transposons, and housekeeping genes. Their function is unknown.	25.00	25.00	25.50	25.40	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.53	0.71	-4.50	25	190	2009-01-15 18:05:59	2007-05-03 16:38:58	5	3	179	0	48	143	15	120.50	37	43.17	CHANGED	pscslHsclhchsppphhss..pYhcAVhEAsKulss+lRptoGl..stDGssLhppuFu.sc.........pPhLtl..sshpocopcupQcGht.......sLhpGhhssaRNspAHcsc.hp.....hocpDAl-hLuhlSlltRhL	...............p..+tlHsclhpaCcschl.....sc..sYacAVhEAsKulsc+lRpho..Gl.......s....tDGscLlsp......AFs.sp..........pPhLtl..sshpT.coEcuEQcGht.......sLhhGlauuhRNPhAHps+..hp.s......hscpDAL-lLsllShlpR+L.......................	0	15	33	41
+9342	PF09510	Rtt102p		Rtt102p-like transcription regulator protein	Wood V, Coggill P	anon	Manual	Family	This protein is found in fungi. The family includes Rtt102p, a transcription regulator protein which appears to be integrally associated with both the Swi-Snf and the RSC chromatin remodelling complexes, [1].	21.40	21.40	22.80	22.40	20.40	18.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.64	0.71	-4.16	6	33	2009-01-15 18:05:59	2007-05-03 16:40:41	5	1	32	0	20	32	0	128.50	40	65.10	CHANGED	SLIc+AN+.uGYussscpp..HWcY-WhoPs...........KpsEsspp.....P....ss.psp.ppYsFKaKsWl+sssscsh.shhc-ss-.plLDLscFDR........T+hsttspthpspusss....puLohsDIRGAVGGSEuI.......PGhS	................oLIs+AN+..uhYusssscc..pW+YDWYpPs..........................K.ss..usspp.sppp..............ush.pNslEKYsF+YKTWl...+spc.s-p....sLpc-ss-..D.........lLDLp-FDR........Tpcscsss......spsssssusspsspuLosDDIRGAVGsSEuI.......PGhS.............................	0	3	10	17
+9343	PF09511	RNA_lig_T4_1		RNA ligase	TIGRFAMs, Coggill P, Mistry J, Wood V	anon	TIGRFAMs & Pfam-B_49998 (release 17.0)	Family	Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity [1].  tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.	26.80	26.80	27.60	27.20	26.20	24.50	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.60	0.70	-4.87	48	347	2009-01-15 18:05:59	2007-05-03 16:41:19	5	16	314	2	157	357	36	216.60	26	33.56	CHANGED	hpuRGLhhp........................psscIlsRua-KFFNls.........EhstTphcsl..pt.......Phclh.KtsG..sll.hshl.........psG....plllsSKpSs...................................................................................................................psspAptucphlpp.....pltpt..........hppls....ctLhppshTslhE...lsssp.pchVlsYspcphsLhLpshstss.....sca.hshs.hplsph.uc..pashpphchh.thss......th......ttph.ssshpt................ct...hEGa.Vlcsps........................................shhaKhKh-t.hh	................pARGLhhs........................pssscIssRuacKFFNls........................Eh..t..t..oph.pp.l....tph...........PhclhhK.NG...sll...l.shl..............psu............plllsSKpSh...................................................................................................................pssau.phucph.l.pp................phtp...........................hpplt.....ptl.hctshTslhE...lsssp.-..cH..l.lt...Ys.p.pp.hhl.hLtshNhps.......sca.hshs..tplpph....scpauh.....p.....ps.....phh...hhps....hp....pltt.hh........pph....ps..s.hps.................cp......hEGa.Vlpspp........................................shhaKhKhp..h........................................................	0	64	102	138
+9344	PF09512	ThiW		Thiamine-precursor transporter protein (ThiW)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Levels of thiamine pyrophosphate (TPP) or thiamine regulate transcription or translation of a number of thiamine biosynthesis, salvage, or transport genes in a wide range of prokaryotes. The mechanism involves direct binding, with no protein involved, to a structural element called THI found in the untranslated upstream region of thiamine metabolism gene operons. This element is called a riboswitch and is seen also for other metabolites such as FMN and glycine. This protein family consists of proteins identified in operons controlled by the THI riboswitch and designated ThiW. The hydrophobic nature of this protein and reconstructed metabolic background suggests that this protein acts in transport of a thiazole precursor of thiamine.	27.20	27.20	27.60	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.90	0.71	-4.38	26	735	2012-10-03 02:46:00	2007-05-03 16:43:36	5	2	729	0	72	328	1	148.20	47	86.38	CHANGED	LslsAlhlAluVllSslhtIPlGhs+shPhQHhlNVluuVlLGPhauluhAhlhullR.hlGsGolLAFPGShhGALLAGl....hY+hs+.+h...hhAslGEllGTGlIGuL.luaPlAshlhG.spsuh...hhahssFhhSolhGulIuahlLhhLp+p	.....LslhuhhIAlsVVLSsI.hpI....tt.hAPhpphVNlLuuVhlGPhYuLAhAhloullRhhhtsh....ssLAhsGuhhGA....LLAGl....FYpa.......s..+...+h......ahuulGEllGTGlIGSl.lua.PlhhhhsG....pst.tl..............hhahspF.hsuolIGohIualllhhLpK.p.......	0	36	52	66
+9346	PF09514	SSXRD		SSXRD motif	Bateman A	anon	Pfam-B_23332 (Release 21.0)	Motif	SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localise to this region [1].	20.90	20.90	21.40	22.20	19.00	20.40	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.43	0.72	-4.64	33	133	2009-09-11 15:10:05	2007-05-03 16:52:11	5	18	25	0	55	155	0	32.80	56	11.21	CHANGED	pssthpVpsWoHRLRERK.hVIYEEISDPEEE--	.......pss++thc.sWoHRLRERK.hVlYEEISDPEEDDp.	1	12	12	13
+9347	PF09515	Thia_YuaJ		Thiamine transporter protein (Thia_YuaJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this protein family have been assigned as thiamine transporters by a phylogenetic analysis of families of genes regulated by the THI element, a broadly conserved RNA secondary structure element through which thiamine pyrophosphate (TPP) levels can regulate transcription of many genes related to thiamine transport, salvage, and de novo biosynthesis. Species with this protein always lack the ThiBPQ ABC transporter. In some species (e.g. Streptococcus mutans and Streptococcus pyogenes), yuaJ is the only THI-regulated gene. Evidence from Bacillus cereus indicates thiamine uptake is coupled to proton translocation.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.22	0.71	-4.51	43	674	2012-10-03 02:46:00	2007-05-03 16:53:45	5	2	640	2	112	689	6	171.80	34	87.25	CHANGED	llEhulhsAlAhlLshl...hhphPpGGSlol.uMlPIhlhAhRaGhpsGllsGhlaGlLpll...hu.......s.a..llpshQslLDY.lAFsslGlAGlFtp............................ttt......hhhhhGsllushsRahsHaluGllFaGuYAPcGh......sshlYSllhNGoh.hlsshllshlllhlLhhpts.phhh	............................hlEsAlhsAlAhl.Lshl.....h.h.ths..p..G.h....Sloh...uMlPlhlhuhRhGhtsGhhuG.hl.aGl.Lphl...lG..............sha...hLsss.Qs.l....l..-..........Y.......hl.....AF..........u.h.l..G..h.A.G.l.F.tp.h...........................ttphh.th.hhhl......hhusl...l....ush...s.R..ah..h.Ha.lu.G..l.l.F.a....Gs..Y..A.....Pc...Gh................sshl...YS..h.l.h..NGoh...hlsshllshlllhlLhhs.sph..h.........................................................................................................	0	51	86	99
+9348	PF09516	RE_CfrBI		CfrBI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the CfrBI (recognises and cleaves C^CWWGG) restriction endonuclease.	25.00	25.00	96.00	95.50	24.50	23.30	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.85	0.70	-5.51	5	36	2012-10-11 20:44:45	2007-05-03 17:06:14	5	1	36	0	1	27	2	257.80	52	84.94	CHANGED	MpFc-.........................plh++VIpcVLpGcDYREpl.......lNtlNsEFLDFu......IDFFK-lloAKhpspslsL-WYpcasLuNKu..Pc.-lAI..hsGhNpKTIpNlYGouoKpVVlshupsplchL.sulppLu.csQ--IG.IslKIsY....K-lSVs...LsLcESLlVINALAoK+lsLRGStaSohGKplEKhLMLoLCplhGlc.....E-slsAcsFsKsKutDhDRElDFpL.plcsuKtYRVEVKLMGKGNPE.............SADAVIARsosIFIADTLS-QNK	....................................slp+sIphLL+GKDYREhV.......LNsINsEFLDFA......IsFFK-IlhAKMpDcuIshsWYppashsNK-..sK.-lAI..LsGhNhKTIhNsYGToTKEV.VLDlupsNlcYLh-l.LQsLppss.s-lG.IsIKITY....K-ISVs...LDLcESLlVINALATKKIALRGSAaShlGKRlEKPLMLpLCc+CGlS.....EuaIDAosFpKDK+L-aDREVDFKLYNpD+SKsYRVEVKLMuKGNPE.............SADAVIAR-ocIFIA.TLSEQNK...............	0	1	1	1
+9349	PF09517	RE_Eco29kI		Eco29kI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the Eco29kI (recognises and cleaves CCGC^GG ) restriction endonuclease.	23.00	23.00	24.40	23.00	22.40	21.00	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.10	0.71	-4.93	6	60	2009-01-15 18:05:59	2007-05-03 17:25:00	5	2	56	17	15	56	3	164.70	44	74.26	CHANGED	PcpFpGAGVYALYYsGsasLYcphu.chNchsastPIYVGKAVPtGhRpuRhucNss..uspLasRL+EHuRSIupsusLDlsDFhCRFVlh-hthSshIshhEAsLIchapPlWNosVDGFGNHDPGpGRasQ.....t+SsWDslHsGRsWAs+hss................h.uc..uItcsIppaLcp	...............cpFpGAGVYAlYYhGs.h.shYpplu.chN.R...s.as...t.PIYVGKAVPtGhRput.u.ss..pustLapRLc.EHucSIs.tss......sLc.sDFhCRFlll-...sshIshsEuhLIcha+Pl....WN..............s.....slDGFGNHDPG+GRapp.....t+ScWDslHPGRsWAp+hps................hspohcplhppltpaht.t.....................................	0	4	12	14
+9350	PF09518	RE_HindIII		HindIII restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the HindIII (recognises and cleaves A^AGCTT) restriction endonuclease.	25.00	25.00	66.40	66.20	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.90	0.70	-5.52	5	26	2012-10-11 20:44:45	2007-05-03 17:38:09	5	1	23	8	3	23	3	278.00	34	94.43	CHANGED	NuE.........hl.s........hss-hlKlsuphT.Dac+lss-llptI+KhsccplI-lLpouGhIPEsYcsDSSEEKLFSKhsDALlu-shpchGapApsLsERusAuDVhltsc..sptIVuDAKoFRLSRT..AhNsKDF.KVculcKWRstht.sKDaulVlsPpaQhPssKSQ..lYsQulDpNVLlLSYcHLAaLLcp+-.hss-hh..LWEYpsIFspp.hhN.suKsu+pYWsuINcsllclssct-KtahDphstscctLpphlcccIp.lE.....chEalcpEIs+IhshoREcAIR-LlcchKIpu+lEph.phl+slpcpcl	..............h...................t..phsu..s.-hpphstcl.t.lpp.spptll-hLppsGhIPEshptDSSEEKLaSKhsDsllucshphhGhpupsL.sERusuuDVhshsp..sYtlVADAKsFRLSRT..AKNtKDF.KVpulscWR...p....sKDaulllsPhaQhPsppSQ..lYpQulspNVhlhoacHLAhLlphtt..s.c.....Lh-......tIFst..hh..stcpuhpYWpslNpshhphssphpchah-.hthspctltphhpptI...........cahppEhppIhtho+-cAlptLlpph+lpu+lcth...hcthpp.................	0	3	3	3
+9351	PF09519	RE_HindVP		HindVP restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the HindVP (recognises GRCGYC bu the cleavage site is unknown) restriction endonucleases.	25.00	25.00	26.00	34.60	23.10	20.50	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.83	0.70	-5.53	3	41	2012-10-11 20:44:45	2007-05-03 18:03:25	5	3	34	0	4	50	1	255.10	38	90.73	CHANGED	oWGKNQFNSSFPlALACYMSSKNIpPlYL+LE+.tsIcHupIDVcsVFpIcP.ptpsFFAFEpSY..............................pIKLTAlPDpTTssLsDs..GsEIVIRPDoIVYLAhSlAclhpps.hshhDI..PssschhDWp-sppl.PhhPhhhphL.slhsRhpslQhPhLLQPlWKT.GK.shLtDNCLDIFlWSNlAFsKlFLDASplclNscSITRpcRTsVWLhKMLYDFApsGKINH++TIDcISaNTKNDKAFAuSGMlT+pYMKSPELp+PRIK+cEIKNIILGGGQ+LLSPERRFDAIIlNTPsLF-	.....................aGKN.FssuFP.uLhsah.p.ptlps.Ylhh....p..p..............plppt.lshpplashps...s.tphaasFEt.a...............................hElKLTslPDpsTtphs-p.ausElVlRssol.ahAhSlspth....pp..ph..t..t.hh.h....h....cWsp.tplhshh.phhtslpplhpph.shQpPhlhQPlWKTpGKps.LspsCLDlFlWSshAFs+hhlshu....p.s..p.....pIsR.tRohlWLhKMLhDhsppGphsappllcphoasspsDKAFuhsGphTp.aMps.clppPtI.+pEIppIILssGppLLSPERRFDuhlh.ssspLF.................................	0	2	4	4
+9352	PF09520	RE_TdeIII	RE_MjaII;	Type II restriction endonuclease, TdeIII	Bateman A, Coggill P	anon	Bateman A	Family	This family includes many TdeIII restriction endonucleases that recognise and cleave at GGNCC sites. TdeIII cleave unmethylated double-stranded DNA [1].	23.80	23.80	24.00	23.80	23.70	22.70	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.67	0.70	-5.08	11	54	2012-10-11 20:44:45	2007-05-03 18:10:25	5	1	48	0	19	62	14	233.10	26	89.78	CHANGED	Mulss...tT+NKl+-aLsshlccpLpsY..pt.hp.............ss-sshpPFHtpLlPtslMplt+FERSLsTuLGp.hFEpsA+lIAhspausA.ppYclpsslsptshssIDpllsplc..........+spppppsohsEhlcplpplspsthtEsolV.uDLYlp+cDGpEhaF-IKSsKPNKGQshpshpcLLRlhAlc..pp.tssscsFaAhsYNPaG....p+tuYohshh+thhDhcs.tVlIGpEFWshIGp.suTYsELL-Iac-VG	.......................................................................httlpphlpp.lcph...hpph....................psptt.hP...Fhttll..............st.............-........hhthspF.+ShsTshGpshaEplAphlApspht.s.p.phpht.sp...IspptpppIpplhsplc..........t.ptp.sph.p..ctlct.h..hph....sp.tp....h.psphs...Dl.a.l.p.pp.s.sp..hhh-lKo.....s.....K.P.NtsphcthKpplLphhshh....pp......ptphpsahAhPY.......NPa...........p.psapp.......h..ht..th.h....Dh.-p..plllupEaWshluG.csoY.pplLchapclG...........	0	9	12	17
+9353	PF09521	RE_NgoPII		NgoPII restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the NgoPII (recognises and cleaves GG^CC) restriction endonuclease.	25.00	25.00	35.90	35.90	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.76	0.70	-5.61	4	62	2012-10-11 20:44:45	2007-05-03 18:15:05	5	1	53	0	7	42	7	186.50	42	93.41	CHANGED	M...pNIlsAIhNlspNP.hpLcpa...spS+NRANpMG-uLEEYlKDlFusoh.p.D.sp+.tlauchFSYLGNpNNPPDhIL+sGDAlEVKKIEshcSSLALNSSYPKuKLasssSMIT-AC+sCEcWE.KDIIYsIGTlccpp.LKtLhhVYG-sYAA-splYp+IpspIKtGlpsIsslpFSETpELGRVNRVDPLGITYhRlRGMWGIENPhKVFsYIhph-..csppFNhhAlhpc-KYpSFsspD+hc.huhpNptLtIpDl+IKs	...................NIlsAlhNlhpp......h.tlpp.....pu.sRANphGsuLEpalKDhFut.................................hl+tG.sulEsKKhps...s.ssLsLNSSaPKs.l..ss..l..pth+ttE..pWcpKcllYhlGhh.p..pp..LppLhhVYG..asAptphY.clcppIppul.tph...ss..l.hscTpElG+lpplDPLsho.LRlRGMWtIppPhhV..Fp....lht......ppthphhsll..tcatphspp.c......p...h.tlpch.l........................	0	0	5	6
+9354	PF09522	RE_R_Pab1		R.Pab1 restriction endonuclease	Bateman A	anon	Bateman A	Domain	\N	25.00	25.00	60.20	29.80	18.40	17.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.65	0.71	-4.21	5	56	2009-01-15 18:05:59	2007-05-03 20:02:19	5	2	32	6	4	55	0	116.20	69	53.14	CHANGED	KQKQFIEDNF..MITRERFRSHQFGGMDFELSRISYPLLIHSFDD.NELSEIVIKEQQYGSKTQAMLYFCFSILELKTATPLLNRTAphKEHALLlIHcsNAshFLEMLKIFGLLSQsHHNDVLKILEKIL.QN	..............................KQKQFIEDsF..hIsRERFRSHQFGGMDFEhS+ISYPLL.IHsFND.Np.LSEIVIREQQYGSKTQAMLYFCFSI...L...ELKT...A...TP...........LLNRTAsLKEHALLhIHKTNA.hFLEMLKIFGLLSQAHHNDVLKILEKILpN....	0	1	2	2
+9355	PF09523	DUF2390	CHP02444; 	Protein of unknown function (DUF2390)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are bacterial hypothetical proteins, about 160 amino acids in length, found in various proteobacteria, including members of the genera Pseudomonas and Vibrio. The C-terminal region is poorly conserved and is not included in the model.	25.00	25.00	26.30	27.90	22.50	19.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.40	0.72	-3.88	60	298	2009-01-15 18:05:59	2007-05-04 09:10:55	5	1	295	0	89	240	56	106.10	35	65.72	CHANGED	psLWpauLshYupsuVppuCLpLQsphGssVsLLLhshWLs.....p..pshshsspphptltstsppWcpplltPlRplR+ph+stssps..........lhcplhshELpuE+hp.phLh	..p.pLWpFuLphYut.tVcpA.CLp.LQspptuNVNLLLhhtWLs.....p.ptl.shsppchtpltpslsphp-sllpshRcLR+phKsphscs..............LhcchhphELphE+ppttpL.h...........................	0	21	44	68
+9356	PF09524	Phg_2220_C		Conserved phage C-terminus (Phg_2220_C)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents the conserved C-terminal domain of a family of proteins found exclusively in bacteriophage and in bacterial prophage regions. The functions of this domain and the proteins containing it are unknown.	21.10	21.10	21.20	25.60	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.64	0.72	-3.98	26	362	2009-01-15 18:05:59	2007-05-04 09:12:02	5	7	326	0	39	286	12	73.70	47	26.64	CHANGED	IIsYLNpKuG+sF+.ssptspcLI+ARhpEGasl-DFKpVIDhKspcWhsssp.....hppYLRPcTLFu.s.KF-uYLNp	...................................IIcYLNcKsG+pa+h..s..otpopchI+ARhs-.GaplE........DFKpVIDhKss-Whsss.......hscYLRP-TLFG..sKFEuYLNp........	1	16	26	37
+9358	PF09526	DUF2387	CHP02443; 	Probable metal-binding protein (DUF2387)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are small proteins, about 70 residues in length, with a basic triplet near the N-terminus and a probable metal-binding motif CPXCX(18)CXXC. Members are found in various proteobacteria.	24.40	24.40	24.50	25.00	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.96	0.72	-4.06	44	844	2012-10-03 10:42:43	2007-05-04 09:13:20	5	3	840	0	112	300	136	62.10	57	89.83	CHANGED	hKKRFIAGAsCPpCsphD...plthap-ss..l-hhECVpCGas-ppssp......tsphpsR...............sptpsIsl..F	....RKRFIAGApCPuCpAQD...ohAMWRENN....l-lVECVKCGHp.RcsDK......pscc+VR...............pcEQVIGIF.......................	0	18	40	78
+9359	PF09527	ATPase_gene1		Putative F0F1-ATPase subunit (ATPase_gene1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This model represents a protein found encoded in F1F0-ATPase operons in several genomes, including Methanosarcina barkeri (archaeal) and Chlorobium tepidum (bacterial). It is a small protein (about 100 amino acids) with long hydrophobic stretches and is presumed to be a subunit of the enzyme.	23.00	23.00	23.20	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.74	0.72	-4.16	277	1319	2009-11-03 13:52:42	2007-05-04 12:08:56	5	2	1253	0	429	996	1353	54.40	25	56.48	CHANGED	uhhht.l..Ghplls.sll..lGs..hl.GhhLDphh...so.t..shhhllhlll.GlsuGhhshh+hhp	.............h..hhtl..uhphls.ull.lGs.hlGhhLDchh.......ss....Phhhl.....lhlllGlsuGhhslh+hh...........	0	172	321	377
+9360	PF09528	Ehrlichia_rpt		Ehrlichia tandem repeat (Ehrlichia_rpt)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Repeat	This entry represents 77 residues of an 80 amino acid (240 nucleotide) tandem repeat, found in a variable number of copies in an immunodominant outer membrane protein of Ehrlichia chaffeensis, a tick-borne obligate intracellular pathogen.	20.50	20.50	21.20	20.90	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	688	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.09	0.70	-13.79	0.70	-6.39	2	47	2009-01-15 18:05:59	2007-05-04 12:09:46	5	4	7	0	6	47	2	244.40	44	123.71	CHANGED	MDIDNsNloTushpspossLh-lIMRILsFGNps..psps.soclh.pp.p...sDsVupPS................LpPhVstS..........cVScsppEcosPEVhhcDLQ.....sltpppStVu-psupsspEcps.Elcucphpsth-sulpcSppc.sEhVSpoSpE..ssE......................pcVSKsppEEosPEVhhcDLQ.....sVtpppStVu-psupsspEcp.....................SEltp+.ucTpKEpuhsEs+tc-.....D-.VppsSSE...stpcVScsppEEssPEVhhcDLQsssstp..........VpcppSEltp+.uETpKEpuhsEs+tc-.p.sspsS.E..suE..pcVScsppEEosPEVhhcDLQ.....sVtpppStVu-psupsspEcpo.Elcucphpsth-uulpcSppc.sEhVSpsSpE..ssE......................pcVScsppEcosPElhsEDL.......ltps.s.VsEK.sEh.t.p.sP.VhtE-.................-KVsETscpE...Elht-sQsVtsupsl.lsPM.sl-shDo.l...........SslhpstMhCPhSc..sGpaVphYthYhYthQsVKDL.Gsh..shssC.CNlslYFhtaN.FTN+Esl......Dll	.......................................................................................................................................................................................................................................................................................................................................................................................sptp..........VpcppsEltp+.uETpKEpuhsEs+tc-.p.VspsSsE.alAE..pcVSKl-pEEosPEVll+DLQ.....cVspp-SsVuDpsupsssERpo.Elcucphpsth-uulpcSppc.sEhVSpsSpE..ssE............................................................................................................................................................................................................................................................................................	0	4	5	5
+9361	PF09529	Intg_mem_TP0381	intg_mem_TP0381; 	Integral membrane protein (intg_mem_TP0381)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of hydrophobic proteins with seven predicted transmembrane alpha helices. Members are found in Bacillus subtilis (ywaF), TP0381 from Treponema pallidum (TP0381), Streptococcus pyogenes, Rhodococcus erythropolis, etc.	21.80	21.80	22.20	22.30	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.70	0.70	-5.11	43	802	2009-01-15 18:05:59	2007-05-04 12:30:38	5	1	697	0	95	583	737	219.40	29	92.57	CHANGED	hhsFphaussHhshlhhhllhslhlhhhhp................phptpppphhpphhshlhhlphluhhhah..hhhshhsltpsLPLahCcluhhhhslhLlscp..phhhphhaahGlsGuhhALlsP-l..........................................sasFPHhpahsFalsHhhllhsslahlhhpph+sshpshhtsllhshhhshhlhhlNhlh..........GuNYhaLsppP.hssohLslh...ssaP...hYllsthslshhl...hhlhh............................hsat..hpc	................h..shphhpss+hslhhhhhlh.sllhlhhhp................thp.h.p.p.p..p.h.hphhh...thl.hs..phlhL..a..sWa....hs...s..............th..s....L.s.p.SLPhahC+lAhh..s.lh...lls..p....p......p+.ht.p.......h....hh.h...h...GhhGulhA...llhPs.h.........................................ssY.sF.P.HlshlsFhhuHhsLlhsuLhhlh...c..p..Y.c.sph.hshpthhlhshslssll.hhVNhlT................GGNYuF..LscsP....ssp..h..Lsh.......................Yllsshllshhl.....hhhh....................................ph..................................................	0	32	65	82
+9363	PF09531	Ndc1_Nup		Nucleoporin protein Ndc1-Nup	Wood V, Coggill P	anon	Wood, V	Family	Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.	19.90	19.90	21.20	20.20	19.70	19.80	hmmbuild  -o /dev/null HMM SEED	602	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.89	0.70	-6.10	34	331	2009-01-15 18:05:59	2007-05-04 13:22:05	5	8	241	0	220	326	0	466.90	18	88.01	CHANGED	ppllppRhst.ustlslhlshlhhhshhl..........thhohhhshhsh...hh+slhlhluslllhlhRhp.hpl.t.psp..sohhsplhptlhshphl.hhlhashuuh.hhuhhath.hstsh..t..hh.................t.tppshLN-phlalhhhthhluhhh...........oltalhhshsclsF..............s....hpp..tppltppl.phlhpu..lhpohhshhstsllY..................hh..hh.hshh.h.thhhshsps.h.sshh...hshpllhphhlhuhhllhsW..phsNhhFslahops.slctspsloshop-Ppt..oLlsGLp.spc....hs+hhAhpELshluppsssc....Rpslasspptss..ssWstlhcpChplIpphssclsphhpt.t.....ststhss..ppppspp...........................................................t.......t...h....st...pt..h.t......hptshsppshpssssssthst.tp..pttpplhsthpphhp...............................................................hpphLpphhsh.athohp+pspshl......ss.hhspAl.uLotLlhtSlpEDpaGsVpss.lspllphlpchhtslspahph.sssshhst..............tttpp......stlphlhsshpsulhcIshpFstaLp-lhLsscsh+hhp	.......................................................................................................................Rh......hh.hhh....h....h.h...............................h.....h..h.h.h.hs.h..hh..hh.ht.hh....h............s...ht...h...h...ph.h.h.hha...h.uh..hhs..hh...h...h..........t............................................hst...lahh...hhhuh.............sh.hhh.p..hthl.h.....................sh.....t.....h.hhtt.l..hh..hpu..hh.shh.hh.h..hha...................h.....h.....h.thhhs..hp.........s.....h....sh.......hh.hphhhhuhh.lhhha..ths...hhapha.hspt.sh.....t....ss..hsps.spt......sLhpsLp..sp............................hhphhA.h.-Lhhlupt..ssp.....RttlFp..p...t.......s..s..tsWstl.ptChphlpthspcl.th.p..........s......t....t....................................................................................................................................................................................s.......................t..t.h.h...tp........................................................................htthh..p........h.ah.sh..php..h.......sp...hh.uhp.uL.stLhhtShpEDpaGhVpps...lstllphhhph.tslcph.....h........t................................................................t.........t.h..hhhtshppulhplh.tFt.hlptl.hs.p..p.................................................................................................	0	65	111	182
+9364	PF09532	FDF	DFDF;	FDF domain	Anantharaman V	anon	Anantharaman V	Domain	The FDF domain, so called because of the conserved FDF at its  N termini, is an entirely alpha-helical domain with multiple exposed hydrophilic loops [1]. It is found at the C terminus of Scd6p-like SM domains [1][2]. It is also found with other divergent Sm domains and in proteins such as Dcp3p and FLJ21128, where it is found N terminal to the YjeF-N domain, a novel Rossmann fold domain [1].	26.10	26.10	26.20	26.20	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.56	0.72	-3.49	18	611	2009-01-15 18:05:59	2007-05-04 13:55:02	5	11	255	10	383	561	2	97.50	26	19.68	CHANGED	hc.cpDFDFEusNuKFsKpclhcchcpptphtttt.....................ppppssspcpspsssphhs+ppsFFDsISscspccsttss.t..................................apcEcchs..ETFGhst	..........................................ppDFDFEusNApF.sKpc...l..h.......cch.p.pp.p.h......t...t.p.pt..tt..t.........................ptpptt.pp.c.s...h.s.ss......t.h...hs+ppsFFD.s.l.Sscs.p...p..pp...p..s...............................................atppc.phs..-TFG..................................................................................	0	78	159	280
+9365	PF09533	DUF2380	CHP02269_MYXXA; 	Predicted lipoprotein of unknown function (DUF2380)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of at least 9 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. One appears truncated toward the N-terminus; the others are predicted lipoproteins. The function is unknown.	25.00	25.00	25.70	25.60	23.40	23.40	hmmbuild  --amino -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.40	0.71	-4.88	8	28	2009-01-15 18:05:59	2007-05-04 14:10:00	5	2	8	0	27	29	0	164.80	35	60.96	CHANGED	uhpsApEtCsssDEspCVSLLCpGDA.CGFYcCEDlsGcVEh.ARFPPA.....RPPsAsAAPGpGPRRsWGsGQpLPRGA..VMVFPsWsGAPpchlsPuhpLsPG.RWEKHHIFPQAcDLAcWFpp..+GVKIHDYThPIPR-lHRRIHuGsspGGAWNcAWR-F+cpp.G.A.SP-EIa+HAGELIaRFELhGGPIpPY......YSR	...........................................t...t.t..Cttspts.ClshhC.tsh.CuhahCEDlss...ts.h..uth.ss.......RPPh.......G.sspRsW.Gtt.tl.tss..lhsF..W..t.t..h.sshphssG.ca.....cKHHIFPQt.cLApWFpp..pG....lcIHcaTlsIPcclHpRIHuGs............s..p..GGs..WNpsWRpFhpts.t..A.o.pplac+AucLIhRFpLh.G.l.sYa.................................	0	11	13	21
+9366	PF09534	Trp_oprn_chp		Tryptophan-associated transmembrane protein (Trp_oprn_chp)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are predicted transmembrane proteins with four membrane-spanning helices. Members are found in the Actinobacteria (Mycobacterium, Corynebacterium, Streptomyces), always associated with genes for tryptophan biosynthesis.	24.90	24.90	25.00	25.10	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.36	0.71	-4.68	24	358	2009-01-15 18:05:59	2007-05-04 14:15:32	5	2	348	0	99	256	3	178.30	31	85.29	CHANGED	tIA.tLlLlluAusLWhAuRhsWVslpSFDsLGs........P+sssLoGAoWooALlPLALLhLAAsVAslAVRGWsLRlLAlLlAsAususuYluloL.WV....ss-sAsRuusL..ApVPlss..lsGopRphhu...........AslullAushsLluAVLLhppAs.ptsAts..uRYssPsARRutApppts.....t............hSERhlWDALDEG+DPT	...........................h....hhhhhuAhhh.hhu.up.sW..h.h.s..s..hs..........shthsloGushosu.L.h.ulALlhlAu.ssAs.hs.V.RshuRRllulLhAlsuhuhshhslsh...hh...ts.s.s.Atpsush................sts.s.sst......hsss.pho.sWs............hlslluuslsl.luulhLhhtus.chsutu......s+Ytt.tARRstthpt...............................................................s.Rsl..WDALDcGcDPT.....................	0	30	74	94
+9367	PF09535	Gmx_para_CXXCG		Protein of unknown function (Gmx_para_CXXCG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry consists of at least 10 paralogous proteins from Myxococcus xanthus and that lack detectable sequence similarity to any other protein family. An imperfectly conserved CXXCG motif, a probable binding site, appears twice in the multiple sequence alignment.	25.00	25.00	29.00	28.40	20.70	18.80	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.59	0.70	-5.36	11	36	2009-01-15 18:05:59	2007-05-04 14:22:52	5	2	9	0	31	35	0	184.80	40	91.83	CHANGED	RFahl+cDcssp..aTGsL.sAsH+WuLPGVpsCssCGsshGssGhpYPCVDLSsLP..EppchscP.hPlsaEEFuRLRELVRPhAPPGAhL.PGTphGPLsGsASGpFGsLhhQsshsLhlRREALERLputGlRGLpGCsh-lRFRtKsPPELLELQLE.+GRLHPDClPsDctPPCssCGsp.shphP.-sslLDAsSLPsslDlFRltsasTlIluTERFVEAVc+LcL-GlsFpELssR	...............................p.s.s.....hsGth.pu...WthPGlt.Cs.st.shu..h.tYPsVDLuths..t.t.h.ps...h..shpEatRLtp.lRPhhP.th.l.PGsthGPhhGtupGtFu.h.h.ss..lhlRp-Ahc.Lpt.GlpGL.us.hpl+hRtptsPtlhcLplp.pGplH.cChssth.ssCspCGp..sh........phP........ct.hL-stSLPsshDlFRltsasThlluTERFV-Alc+LtLsGlsFpElss+...	0	12	12	23
+9368	PF09536	DUF2378	Mxa_TIGR02265; 	Protein of unknown function (DUF2378)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of a set of at least 17 paralogous proteins in Myxococcus xanthus DK 1622 and and 12 in Stigmatella aurantiaca DW4/3-1. Members are about 200 amino acids in length. The function is unknown.	21.20	21.20	23.10	22.50	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.81	0.71	-4.75	27	82	2009-09-10 15:59:30	2007-05-04 14:23:17	5	1	10	\N	69	82	2	174.80	24	87.95	CHANGED	thhs.sp...sscGLFhpulhstlp....tthtpcl+psuh....-hcts.h.sYPltsahphlhsAAptltPph..s.-sAhRtlGcphspuFh.pohlGRslhslhthhuP+Rhlsplspua+.uussYsEpplp.h...Gspssclhhpcsh..sssappGlLpusLcssGAps.pVpspthsh.hsssYclsWp	........................................hh.tpshcGLahpulhshlp........tthtpclctsGh...-hct..h.sYPhptahphhtssAchlhPth..sh-tAhctlGcphspuah.pohhG+slhslhp.hhuP+RhLpchspuap.sussasctplpth...Gspssclthp...........cshh..sss....att....GllpusLchsGupsspV...p...spthss.t.sspYclpWp.......................	1	20	20	50
+9369	PF09537	DUF2383	CHP2284; 	Domain of unknown function (DUF2383)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	Members of this protein family are found mostly in the Proteobacteria, although one member is found in the the marine planctomycete Pirellula sp. strain 1. The function is unknown.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.89	0.72	-3.82	79	432	2012-10-01 21:25:29	2007-05-04 14:23:56	5	2	358	2	189	457	26	109.50	24	67.21	CHANGED	pslss..LscLlcsshDuppGacpuu-clc..s.spL+shhpchupp+pptspELpstlpphG..scPcss.uShsGslHRsahsl+utlousc-p.slLpcsEcGEctslcpYccALc.c	...............hhptLNcLlctspDutcuacput-csc...s...spL...+........shhpchsppppptspcLpshlp.phG...ucPpps...uohtGslp+sahsl+s....hhss..p.c.cp...lLppscc.uEctshctaccslp.......................................................	0	49	115	153
+9370	PF09538	FYDLN_acid		Protein of unknown function (FYDLN_acid)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are bacterial proteins with a conserved motif [KR]FYDLN, sometimes flanked by a pair of CXXC motifs, followed by a long region of low complexity sequence in which roughly half the residues are Asp and Glu, including multiple runs of five or more acidic residues. The function of members of this family is unknown.	23.80	23.80	23.80	23.90	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.31	0.72	-11.07	0.72	-3.47	63	299	2009-01-15 18:05:59	2007-05-04 14:25:01	5	1	295	0	110	234	357	112.80	36	90.88	CHANGED	MsKtEhGTKRlCPssGp+FYDLN+.sPllsPhsGpshshc................ss+s+thtspt-c...................scpscsssss-.ssl--s-s-.p..................p-s..t..--....DL-s.-DDs.......hcD-D-	........MAKsELGTKRlC..PpsGcKFYDLN+.cP.ll.sPasGpshshs................hhcspt..tsst-cst................tpchcss..pps.-hssl--.s.Ds.-sph...................................sDDl.s..D.sDD...sl-ls-...DDDs......hhtp-----p...................................	0	33	70	85
+9371	PF09539	DUF2385	CHP02301; 	Protein of unknown function (DUF2385)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this uncharacterised protein family are found in a number of alphaproteobacteria, including root nodule bacteria, Brucella suis, Caulobacter crescentus, and Rhodopseudomonas palustris. Conserved residues include two well-separated cysteines, suggesting a disulfide bond. The function is unknown.	25.00	25.00	58.40	58.10	18.80	17.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.20	0.72	-3.61	16	161	2009-01-15 18:05:59	2007-05-04 14:25:50	5	1	159	0	59	119	6	95.00	52	72.36	CHANGED	PY-tpLhRLAEILGulHaLRsLCu.tscsspWRscMptLL-uEsss-.pRRpRLhuuFN+GYRuFussYppCTsuAphAhpRYhpEGpsLoc-IsuRY	.......PY-schhRLAElLGoLHYLRsLCG..pcGscWRccMpAlIsAEpPs-.tcRt+LluuFN+GYRsFussYspCTPuAhsAlcRYhcEGucLSp-IhuRY....	0	15	31	40
+9375	PF09543	DUF2379	CHP02267_MYXXA; 	Protein of unknown function (DUF2379)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of at least 7 paralogs in Myxococcus xanthus and 6 in Stigmatella aurantiaca, both members of the Deltaproteobacteria. The function is unknown.	20.00	20.00	20.20	20.00	19.70	18.30	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.41	0.71	-4.16	16	44	2009-01-15 18:05:59	2007-05-04 15:28:38	5	2	5	0	43	43	1	103.10	42	91.86	CHANGED	scphDWsPIRuLu+RVlcpGEPLtLTc-VRALLpRoAcEVuIosu-sppALuosssAtsLLcEhpRRI+-GSpRLhcAlpRhhchp-AGDlDuARppMc-VLAVEVVPhYRchApspLcsls	......s...-Wp.lttLs+RV..ptGtsL.LotchRuLLh+oAtEVulstt-sttALto.tsAhsLLpEhtcRIp-GSpRL.cAlhc.hhchp-uGDh-uARpphc-lLAVEVVPhYRchAptpLcsh.......	1	9	9	30
+9376	PF09544	DUF2381	Mxa_TIGR02268; 	Protein of unknown function (DUF2381)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of at least 8 paralogs in Myxococcus xanthus, a member of the Deltaproteobacteria. The function is unknown.	20.60	20.60	20.60	20.80	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.67	0.70	-5.30	21	91	2009-09-11 05:39:59	2007-05-04 15:29:54	5	3	9	0	71	90	0	237.80	24	91.05	CHANGED	sLLhussApApss..sspt.ptRsVslsusssp..ssPEV+VussssTsL.lFsuslpccslsl-..cuRhphlDsG..cpolhLtPsssLttGERhcLsVhFtDGssPspAsFlLVsc.Puc.......sDspl-VpRsttsstuhpsE..s........t...t..phcsptstPpshsL.Ghlsp......pGVssp..plpc..hsssupultstsuh..sYRu.tshshVslplcN.suttPWssp..tApLs.....uts.G.sL+shhV.hppuslsPGpt.scVlV.s-ssshusp....ssFT...LcLhspsG.RslplssVph	...................................t..ss.ut...........Rtl.lssp.st..s...lhlusshsThl.hFssslt.tphph-..csRhphlssu..tptlhltshtslt.sE+h.ltVhatDG..t.P.pssFhLssp.ssc.......s-t.lpV.R.ttsstsh.sc..h...................t.pt..ttststshs...h.uhlsp.......pultht....hpt....htssspshthhthh..sapu.tshshl.hplpN.tsttsWtst..tAplp..............stt.G........hcshhl.h.........ptsslh.PGtt..splhl.s-.hss.htst....t.as...Lclht.tsG.Rsl.l.th.................	1	13	13	56
+9377	PF09545	RE_AccI		AccI restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the AccI (recognises and cleaves GT^MKAC) restriction endonuclease.	21.00	21.00	24.60	24.40	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.09	0.70	-5.91	2	13	2009-01-15 18:05:59	2007-05-04 15:31:22	5	2	8	0	7	20	3	229.80	29	92.59	CHANGED	MsYY-pIREhTK.VPVpLVsFEpPRDhARTPTQASSNFITNKEQGDWAEsLlsRAINEsSpNFVAVKYGKSDNLVAGEsGFDsFYQDFQsELDTIGKRPDLLIFpKsDFDsoLGFDlSQ.PHcpITDYVKKAIAGIEVRSSAFLID+YEEAMQsRTp+FspIAhpT+DKILs-F.DVL-HPuRppYIpLLNolThpTlslhDF+VPuWpSs-RLIpVpNLFKpLKsAIKEIQKRDYLSITPKVEDlKVVYKWIETFNVPHFYFQVFFDKVYGISFEQILpIISsSDNDGVIFSVEpDspNQNKTTIKINSKhGhPIA.KVDEPhHESlRKEMDRGRLLFYVTFKGGTAYLDl-NLRsILslEEu.F	........................h..................................sSpFlhphpQGsWuEphlhpAIN-ss.pahAltYG.Stshsss-.puFt.aatchppth.shsKRPDlLlFp.ss...h.p.....................pl..........hV.cAlhulEscsS.ahht+h............................................................................................h.K.EDht.l.cW.pp.sV.hahhpVFFDhhaslSFpph.pll.....p...........u..h.h-p..ps.....p.Khhhhh..p.uh.lh.h.-....P...shh.E........ppG+ll.hVpF.GG.hhl........................................................	0	3	4	7
+9378	PF09546	Spore_III_AE	spore_III_AE; 	Stage III sporulation protein AE (spore_III_AE)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This represents the stage III sporulation protein AE, which is encoded in a spore formation operon spoIIIAABCDEFGH under the control of sigma G. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.	20.40	20.40	20.70	20.70	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.98	0.70	-5.48	32	401	2009-01-15 18:05:59	2007-05-04 15:34:36	5	1	393	0	90	304	11	320.30	36	82.95	CHANGED	lP..phshpphl.shh+.G-t..shshpchhpullpalF+Elhssh+LLupLllLullsulLpNLQsAFp.ppsloplAahlsYhlLlhlslpSFtlAlshuc-sIssMssFM.uLlPlLlsLlsusGulsouAhFcPlllhslshsuplhpslllPLlhluslLpllsslS-ca+lo+LusLl+phuhhslGlhlTlFlGllolpGlsuussDuVsh+TAKFssssFlPVVG+hhoDAs-sVhGsSLLlKNAlGhhGlllllhIshhPlIKllulshlYKluAAllpPlu-pclsssLsshusolhhlhuslusVulMFFlsIsllluuGNls	...........................................................p.phtshh.phlp.Gct..phoh.pphhtulhpalF+ElhsstKLLupllhLslhuulLpsLQsAFp.ppslSc...lAa.hlsYhlLlhlslsSFhlshshAp-sIpsMssFhhuLlPlL.lsLlAouGGlsSuuhaaPlllhhhshsuhlhptlllPLlhluslLplVssl.S.cpaKlo+LucLLpplshhhlGlhlTlFlGllolQGhss.ussDulsl+TAKFssusFIPVVG+hho-As-TVluuSlLlKNslGllGlllllhIshhPhIKlhsluhlYKhuAAllpPlu..s.stll.pCLsslucSlhhlhuslshV..ulMFFloIsllluuGNl....................................................................	0	47	75	80
+9379	PF09547	Spore_IV_A	spore_IV_A; 	Stage IV sporulation protein A (spore_IV_A)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	SpoIVA is designated stage IV sporulation protein A. It acts in the mother cell compartment and plays a role in spore coat morphogenesis. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.	25.00	25.00	30.50	30.50	23.00	22.30	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.65	0.70	-5.80	30	421	2012-10-05 12:31:09	2007-05-04 15:44:18	5	2	408	0	87	296	12	475.10	56	99.67	CHANGED	MEphsIY+DIAcRTsGDIYlGVVGPVRTGKSTFIKRFMElhVlPNIcstac+-RA+DELPQSuoG+TIMTTEPKFVPNEAVEIsl.s-slch+VRlVDCVGYhVcGAlGa..E--p..PRMVpTPWF-cpIPFpEAAEIGT+KVIs-HSTIGlVVTTDGSITDIsREsYl-AEERVlpELKpIsKPFlllLNSpcPtupEThpLpp-LE-KYsVPVlslsstphpccDIppIhcplLaEFPVpElNIslPcWlEpL-ssHWLKpshhssl+-hspslp+lRDIppslpsls-hEalccsplpplshGsGsApIplssccsLFYclLsEhoGhcIcG-pcLlpllc-LupAKcEYDKltsALp-VKpsGYGlVsPpL-EhpLEEPEllKQGs+aGVKLKAoAPSlHhIRADIpTEloPIlGTEKQuEELVpYLLccFEs-PpcIWpSNlFGKSLc-LV+EGlQNKLa+MPE-uQsKLQ-TLQKIlNEGsGGLICIIl	.....MEphcIaKDIAERTsGDIYlGVVGsVRTGKSTFIK+FMELlVlPNI-.N-tc+pRApDELPQSAuG+TIMTTEPKFVPNpAVpIpl......s-ulclplRLVDCVGYhV.GAtGYt..--ssPRMlpTPWa-c.IPFpEAAEIGTRKVIp-HSTIGlVlTTDGoIs-IPRcsYlEAEERVlpELKpluKPFllllNospPhps-..TppL+ppLpEKY-lPVlshsltphcEpDlhslLccsLaEFP........VtElNlslPpWV.hLspsHWL+psa.psV+-slcclp+lRDl.ccs.ltp.hsph..EalccsplstlchGpGsAcIclhs.-pLa.pILpElsGhEIcGcscLlplhp-Lu+AKpEYDpVu-ALc.VKpTGYGlsuPsLs-MsL-EPEII+QGuRFGVKLKAsAPSIHMI+sDlEoEhsPIlGTEKQSEELV+YLhp-FEsDP.pIWpSsIFG+SLpslV+EGlQsKLthMPEsuphKLp-TLp+IINEGsGGLIsIIL..................................	0	46	72	77
+9380	PF09548	Spore_III_AB	spore_III_AB; 	Stage III sporulation protein AB (spore_III_AB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	SpoIIIAB represents the stage III sporulation protein AB, which is encoded in a spore formation operon: spoIIIAABCDEFGH that is under sigma G regulation [1]. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species.	24.90	24.90	25.60	27.90	23.30	24.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.72	0.71	-4.51	37	385	2009-01-15 18:05:59	2007-05-04 15:44:36	5	2	379	0	87	291	10	165.10	33	98.57	CHANGED	KllGulLIlhuoohlGahhupcapcRscpL+pLpsuLphLcsEIhYutTPLs-AhppluppsptslutlFpphuppLppppstostpAWpculpphh.ppssLppp-h-lLhphGpsLGppDhpsQpKplpLshppLcpp.pcAcpttp+ptKha+.LGhlsGlhllIlLh	.......KlhGslLllhuoohhGa..thApphpcRscpL+pLptuLptLcsEIhYupTPLsEAhpcluc.p.......h.s.p.PlshlFpphuppLppsc..p..osp-AWpcul...cc.h...pp...suLp.pp-hElLpphGcsLGppDp-sQpKplcLslppLcppppcAcptptchpKMh+sLGlLuGlhlVILLl...	0	45	72	77
+9381	PF09549	RE_Bpu10I		Bpu10I restriction endonuclease	Bateman A	anon	Bateman A	Family	This family includes the Bpu10I (recognises and cleaves CCTNAGC (-5/-2)) restriction endonucleases.	25.00	25.00	56.80	56.60	17.90	17.70	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.18	0.71	-4.75	8	25	2012-10-11 20:44:45	2007-05-04 15:49:05	5	1	23	0	6	28	5	190.50	33	72.57	CHANGED	QpcLcsSILEEFh.hLhpphhtt....hssplclG......ppsFsslsFh.sohtshhpuscstl+sKDpDFsIG.ptl.lKlohcschspspps.-hslshVAsECKTNLDKsMLp-ssuTAccLKpssPsuLYallsEaLDhs.ssss.ssTpIDEVaILRKp+Rsssphh...............hhchlshsPlss-VhhcLlccVpphLscsu.cssp...sLpRGal	.......Q.cLcsolLEEFh.hLhp.ch.l.t....hssshp..lG......ppsFtsl.Fp.oshtshhpss.shI+pKDpDFslu.pph.h+hohpsp.ssh.pp..phplshlAsECKTNLDKTMhQ-susoApclKtssPsuhYhllsEaLDhT.Phss.phTplD-VhlLRKsKRhssphR...............ahchhsppPlts-lht+llpclpphlssst.ssps...sLpcGah..	0	2	6	6
+9382	PF09550	DUF2376	CHP2216_phage; 	Conserved hypothetical phage protein (DUF2376)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a family of proteins found exclusively in phage or in prophage regions of bacterial genomes, including the phage-like Rhodobacter capsulatus gene transfer agent, which packages DNA.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.29	0.72	-3.81	39	165	2009-01-15 18:05:59	2007-05-04 15:50:55	5	2	163	0	50	131	32	41.30	41	61.95	CHANGED	LtLpPcpFWsLTPsEL.phh...lGhpu.u.s.uPlsRutL-pLhppaPD	.Lth.PttFWthTP+EL.s...hh.........lGhtu..s.s..sshsRspLDuLhttaPD.......................	0	12	27	37
+9383	PF09551	Spore_II_R	spore_II_R; 	Stage II sporulation protein R (spore_II_R)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	SpoIIR is designated stage II sporulation protein R. A comparative genome analysis of all sequenced genomes of Firmicutes shows that the proteins are strictly conserved among the sub-set of endospore-forming species. SpoIIR is a signalling protein that links the activation of sigma E to the transcriptional activity of sigma F during sporulation.	25.00	25.00	25.90	25.80	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.67	0.71	-4.12	40	391	2009-01-15 18:05:59	2007-05-04 15:52:32	5	3	385	0	90	332	8	130.70	44	55.25	CHANGED	lscclIRhHVLANSDSspDQpLKh+VRDpVlchlpstlp..sspsh-Eu+plIpspls-IcclAcphlpcpGhsYsVpsphup.hsFPsKtYGslshPAGpY-Al+IhIGcGcGpNWWCVLFPPLCFlDhoputs	..................lsccslRh+lLANSDSccDQsLKh+VRDtVhttlsshl...s.......sh...p....S.h-Eu+cllpscls-IcchuppslccpGh.s..ssplphuc.spFPTKsY..........G........shlaPAGcYEAlhIsIGcG..cGpNWWCVLFPPLCFlDhopu.s...............	0	47	75	80
+9384	PF09552	RE_BstXI		BstXI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the BstXI (recognises and cleaves CCANNNNN^NTGG) restriction endonuclease.	25.00	25.00	114.10	98.80	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.85	0.70	-5.37	3	10	2009-01-15 18:05:59	2007-05-04 15:59:13	5	1	10	0	2	10	4	279.30	35	80.40	CHANGED	RKIYKTGQT..RGADcssIYQNRVSRNSTVLIPFEhl.pcspEsVstucY-NGYIVLIsPDaYF-cA+s-Kspshp.sstlsLGVNAllaYpQRuQa-cYsP.LsDhpspGL+pTpPhs..RouDl..GGcYVuRlSGTTuE..KcuKIphGaN.Tsu+GAGIRlaEYAssET..LEKARLQLEuhYWLsc-SL-uAIpaGMSscDAccR+c.oaNEAcpQGL........LppIcLlssRIIDccslTlCPLCLp+I............SASGFas+sEQsEhRcsaDLToTEINLFHIsELRYGALpHKPYNLGWGHH	.....................pKl.KTG.T..RGAspstIYQNRVsRNssVLIPachh...sp...tssst.sp.Y-sGaIVLlsPc.YFssstss+hhhhp....tlpLGlNAllaYppRspWssasP..ssh.tspGLshsssps...Rpssl..uGpYVARIsuTT..uc............ctc+I.hGas.....t...p...sh+GAGIRlaEYAopEs..Ip+sRLQLEAhaWLscDSlEshhthGMs.pDshpR+c.sLscs.pcpGL..............................L-hpcLh-hRIls.ccshTICPLCLccI............SApsFas+hEQsEGRcsaDLTsTElNLFHIcELRaGphsHKPYNLGWGHH.	0	0	1	2
+9385	PF09553	RE_Eco47II		Eco47II restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the Eco47II (which recognises GGNCC, but the cleavage site unknown) restriction endonuclease.	25.00	25.00	27.00	27.00	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.28	0.70	-5.21	6	64	2012-10-11 20:44:45	2007-05-04 16:05:53	5	2	59	0	13	61	7	190.80	44	79.26	CHANGED	LoFIS-EDF.NcVpsTIscYpcpLcuh-hK+FsKNlIDPhKhIFDtslap.SacEhlssElhRQp-Ko.sNcIGhFHQ+IhtaIcsh+s.Ps....GaDV.htNs-..........pplasEhKNKHNThsuussuchahKhps.lhsctpp.cDssCahVElIs++SpNhpW.hpsssp+.........upcpIRhlShDpFYpLVTGppDAFpplshsLPhsI-KhlsE	..........................................LsFIoccDh.pcVptTl.pp.Ytct.Lpuh-lK+FN+NlIDPIKLlFDpslaptoaEcllpsElhRQpDKoNsNsIGYFHQpIFpYl.cs.hcVPps....GaD..V.hps.sp............pplalEhKNKHNTMNSuSuupsahKhQsplLpc....ccssCaLVEsIAK+SQNlpW.hplcspch........upphIRRlShDpFYtlVTGpcDAFhphChsLPpllpchlp....................	0	7	9	12
+9386	PF09554	RE_HaeII		HaeII restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the HaeII (recognises and cleaves RGCGC^Y) restriction endonuclease.	25.00	25.00	106.70	106.50	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-12.11	0.70	-5.44	4	29	2012-10-11 20:44:45	2007-05-04 16:07:30	5	2	29	0	2	17	2	315.50	69	92.61	CHANGED	AK-ALDsIIKKuRVHLYKPIQIAEILYpcRs.csL..sL.NL-TYRspSK+WRDlIChRFLGRlSTSSAKaQDNLFEcNAhPPchLslLGp.N+pssGhVEuYIY+pFh-RasQMosuLsYshsosh-NF+LoEFLs.FW.EPGLKRSIDKIYEIVVYALFcsLlppLsVpVcIphshsNlDLLcEFpDFocKllolsupNsphpLsAKhaRVGVTNAADRGLDMWANFG.AlQIKHLSLsE-LAEsIVSSloADRIVIVCKcuEEclIlSLLNQIGW+SRIQSIITps-LIsWY-KALRGpas.llGp+llEplppEIphEFPus.-sNDF.sFhcpRtY	.....AKEALDsIIKKSRVHLYKPIQIAEILYHDRshKpL..-hLNL-TYRNpSK+WRDpICpRFLGRlSTSSAKFQDNLFEcNAhPPE+LuVLGshNRposGGVESYIYKpFFsRFSQMSpALAY..VG..soD+.SFQLSEFLNLFWLEPGLKRSIDKIYEIVVYALF-uLVoELGlTVoIDaPcENLhLhcEapDFu-KIIoh.PcNp+LcLsAKIHRVGVTNAADRGLDMWSNFGhAIQVKHLSLDEELAEsIVSSISADRIVIVCKcAEpSVIVSLLTQIGWKSRIQNIVTEDDLIsWYEKALRGpYs..IAEsLLEsI+sEIhcEFPAV.EANEFl-FtQsRGY......................	1	0	1	1
+9388	PF09556	RE_HaeIII		HaeIII restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the HaeIII (recognises and cleaves GG^CC) restriction endonuclease.	25.00	25.00	25.40	25.30	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.89	0.70	-5.54	4	54	2009-01-15 18:05:59	2007-05-04 16:09:16	5	3	51	0	12	46	1	272.30	48	88.81	CHANGED	G+AaEYAhlpuLtptLsssQcVlIEpNSuhplshcpYcshocphpp+hshuAcAulplILcLEP.Los.lsNss..LhLuIQcDs+Gp.GDVRDILhhRcp.pWEIGLShKHNHsAVKHSRLSRsIDFGEpWFGlPsSQsYaDpIpPLF-cLEphKccG.LWRslsNKE-cIYsPLLcAFIpElc+lspNppulIPpRhlpYLLGp.DFYKlIohDp++lTplQAFNhhGTLNRsSs+c+Phl.lP.h.hPTRhhcIsFKPsS+NTlElhLDpGWohSLRIHNASocVEPSLKFDl+LlGVP	......GRAYEaAhh.sL.pplsh..h.c.pl.ltcpsua.ss.cAapsLpcphpphahtSAhtul.hlhchEPhlp-..sssp..lpLplQpDphGchGDlRDILIhh...c...p..WpIGLSlKHNH.AVKHSRLS+cLDFGc+WhGlssSQsYaDsIcPlFppL-stKccs......hhW+-lsN....KEp-lYhPLLpAFhcElhRhtpp...pps.......lPp+hVEYLLGcaDFYKsI.l-pcphTplpuaNhpsTLN+.ShcpKsphhl.PlspLPTRhlthcFK.....P..........p.....StNTlElhLDpGWpFShRIHNASo+VEPSLKFDIplluhP.......	0	5	7	9
+9389	PF09557	DUF2382	CHP2271_C; 	Domain of unknown function (DUF2382)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry describes an uncharacterized domain, sometimes found in association with a PRC-barrel domain Pfam:PF05239 which is also found in rRNA processing protein RimM and in a photosynthetic reaction centre complex protein). This domain is found in proteins from Bacillus subtilis, Deinococcus radiodurans, Nostoc sp. PCC 7120, Myxococcus xanthus, and several other species. The function is not known.	18.60	18.60	18.90	18.80	17.90	17.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.59	0.71	-4.17	46	499	2009-01-15 18:05:59	2007-05-04 16:29:31	5	9	317	0	179	399	8	106.10	31	43.13	CHANGED	lpLhEE+LpVsKc+hpsGcVclpKcVhp-ppslsVPVc+EcVhlERpslscsspsss.t..phpp.-shc..lslpEEcsslpKcsVlpEEVplpKcssp-scplp-slR+Ecl-l	........................h.lpEE+LpVsKc+lpsGc.Vcl+KcVlp-ppslpVPVc+EElhlE.Rp.slsctsssss..............................t.............h......p-..psh.c.........lslpEEpssVsKcsVshEcVpltKcthp-scplstplp+Epl-l...................................	1	67	126	161
+9390	PF09558	DUF2375	CHP02922; 	Protein of unknown function (DUF2375)	TIGRFAMs, Coggilll P	anon	TIGRFAMs	Family	Two members of this family are found in Colwellia psychrerythraea (strain 34H / ATCC BAA-681) and one each in various other species of Colwellia and Shewanella. One member from C. psychrerythraea is of special interest because it is preceded by the same cis-regulatory site as a number of genes that have the PEP-CTERM domain described by PEP_anchor (IPR013424).	21.80	21.80	22.10	65.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.40	0.72	-4.13	6	23	2009-01-15 18:05:59	2007-05-04 16:31:02	5	1	22	0	10	13	4	70.60	75	92.22	CHANGED	MpsspssVTVLYY.-APsGLlMHNtVlsuLslScsGRVMIPppFR+GKSIIAVLEGECcILNSLGERVauQt	..MQAsQATVTVLYY.DAPVGLIMHNuVLssLPVSEuGRVMIPASFRKGKSIIAVLEGECKILNSLGERVFAQ.A	0	3	5	7
+9391	PF09559	Cas6		Cas6 Crispr	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The Cas6 Crispr family of proteins averaging 140 residues are characterised by having a GhGxxxxxGhG motif, where h indicates a hydrophobic residue, at the C-terminus [1]. The CRISPR-Cas system is possibly a mechanism of defence against invading pathogens and plasmids that functions analogously to the RNA interference (RNAi) systems in eukaryotes [2].	22.80	22.80	27.20	121.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-10.98	0.71	-4.58	10	43	2012-10-01 21:23:39	2007-05-04 16:34:45	5	1	41	0	20	51	26	199.20	32	90.31	CHANGED	lDLsFslpGcsLPhDHuYhLhSALschlPtL+-hsshGIpsl+GsssssG.......llhLo+co+LhlRlPtsplstlhsLsGpsLcluGcplc.LGss+l+tLpPsssLauRhVl..h+sth-E-sFLpuspRpLcshslps+thls....G+..RcTl+hsptsllGauLhlcsLusE-SL+LQpcGLGu+RphGCGLFlPcKsls	...lDlhFslpGpsLPhDHuYsLhsAlpc......hl....PhLp-...p..sslu....lpsIpGssspsG..........hlhLocRo+LplRlPtcpls.t.l.h.s.LsGpsLclusatlp.lGtscl+sLpshssLhuRhVs......hcstp.-tpsFLcsst+pLpplslpsphhls.........G+..........c+slpht....sts....lhGauLhlssLst--SlcLQppGLGu+R+hGCGlFlPpKp..t....	0	10	17	19
+9392	PF09560	Spore_YunB	Spo_YunB; Spo_yunB; 	Sporulation protein YunB (Spo_YunB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Spo_YunB is the sporulation protein YunB. In Bacillus subtilis its expression is controlled by sigmaE.The gene YunB seems to code for a protein involved, at least indirectly, in the pathway leading to the activation of sigmaK. Inactivation of YunB delays sigmaK activation and results in reduced sporulation efficiency.	25.00	25.00	51.20	50.60	23.30	17.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.99	0.72	-4.27	31	313	2009-01-15 18:05:59	2007-05-04 16:36:26	5	1	305	0	78	259	3	94.00	38	40.71	CHANGED	shthplPLGplhssslLushGP+IsV+hpslGsVpssh.pscFcsuGINQT+HpIhlplpspl+lllPhsocshpVpsplPlu-slIlGcVPphY	...s.thslPlGplosNsLLushGPcIPlchpsIGpVso.-l.cpchcstGINpTth..pIhlclcsplpVlIPFtoc.chpVppplPluppll.G-VPshY..	0	38	63	68
+9393	PF09561	RE_HpaII		HpaII restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the HpaII (recognises and cleaves C^CGG) restriction endonuclease.	25.00	25.00	32.60	32.50	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.13	0.70	-5.25	9	103	2012-10-11 20:44:45	2007-05-04 16:40:46	5	3	98	0	15	93	13	324.40	40	95.57	CHANGED	NKGEWSElYshF+LLuDGplahGssplcKhEslhaPIhpIhREE.pstphpY.lcsptlhhl...........sssccchplPhcsFtppApL..lLstlKssp.pcsFshsslEpFhsulshhcLc.ApSosKoDIslslac.cs..pPhhGFuIKSpLGu.sTLLNuG+sTNFhacl...pshphsssplppINulsp.toclt-Rhh.I.chGGhLcYhcltscsFpsNLhhIDsphPclLuchlhhaYtsploclpDLTcplpchNPLphc.p..ppHsFYEaKhKpFLsslALGMpPuKlWNGp.sAsuGallVcpsG-VLCYHIhs+ppFc-YLapNT+LEpuSoSRacFGplhp-NGchYFKLNLQIRF	............sKtEWuElYshh+LLuDGplhhGsschpp..shhaPlhhl.RcE.ccGp.ppYhl.ccpt..lh.l..............psppt.tplPtp-FttsA-h..lLptl+ssp..tppshs.s.c.ulEpFL-ph.sha.c........Lc.A+ocD+oDhplshac.cs.....PhhGFsl+ScLGshssLLsuG+s.sNhhhc.....ts.hpF....s....ssslsclNul.........sp....sclt-RhhhIc.chGGhLcYtclssclFcsNLhhIDhphP+lLuEhlh..hhal-..slocls..-LsEh..lpphNPLKlccp.......pcHsFYEaKhKpFLhAlALGM+PuKlasGps.sAstGhllVcssG-V.LCY.H.h.c+phFcDaLahNo+hEpuSsp..+c+aGhl.+.E..NGsaYFKLNlpIth..........................	0	7	12	13
+9394	PF09562	RE_LlaMI		LlaMI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the LlaMI (recognises and cleaves CC^NGG) restriction endonuclease.	20.90	20.90	22.80	22.70	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.75	0.70	-5.23	2	7	2012-10-11 20:44:45	2007-05-04 16:44:01	5	1	5	0	0	8	11	262.00	54	98.34	CHANGED	MsssKE+lhElFhpNVhGh.PsIpGhsh+HsGthGHWLEc+hGhossAsNcADhhGYEhKN.hTSsKTTaGDWSANEYIFcp...Ns.Fphs.....pstFh+hFGKPNpAKpsRhSWSGpPlPc...pYs.FGQIMsI-EsLsIsIhYSFppD.R.NKF-lhP.phppspl.lA+WYGhtps..S++.psLcsKlpcKFNphGWFpChhcs.ssYscIsFG+PIsFE.WhNhV-pG.laFDSGMYpGNpRsYSQWRu.NSaWppLIp-pap	.........KppII-lF+pNVhG+p...Pchs.uhN.RHDG+c..GHWLEcphGIuANAsNEADlaGYEhKN.oTuuKTTFGDWSAN.YIFcs...ps.aphs.....pspFhchFGKPNttKssRaSWSGSPlPch.sp.YshhGQhMsI--uhsIlIhYSaSpD.R.sKhsIlPspLQp-tl.lARWh...p.....p.csLcsKLpcKFNc+GWFpCppss.GsYscIsFGcPIsF-sWlpLV-pGlVaFDSGMYpGNsRsYSQWRAsNsaW-SLIs-sY..........................................	0	0	0	0
+9395	PF09563	RE_LlaJI		LlaJI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the LlaJI (recognises GACGC) restriction endonucleases.	23.60	23.60	23.80	23.90	23.10	23.50	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.20	0.70	-5.77	12	86	2012-10-11 20:44:45	2007-05-04 16:44:32	5	1	83	0	15	98	4	346.80	21	74.68	CHANGED	FVGl.hsp....sscllhsFPpththspsp.slc.tD.ttLhs....lLp+Yscppsp.....hph.stpsppppshslsshhhllcDahppG.hYpcscphhphNtpGcIsWs+TIpcspPllp....pssshYhphhsc+phps-pshlopIHcasVpcshpph..Galhsh.t.sh.phsht.h.....spshhlphLppclssTFsDcchhLhcuhhshlpppcp..scpp...haGTppFphlWEchhcplF..............sltphp....................shhs+PpWp....hsptp.spshpPDhlhhh....ccp..lhILDAKYYphthp....hcuhPsssDIsKQlhYtthlpphh........ptsclh...NhFlhPhsppsp.ht..sssphphls...hp...t.csht.l..shhlssc	......................................................................................................aVGl.h........tpphhhhhPhhh...pp....thp.....h.h.llp......sl.cap..ppppp..........h..ttstt.t.p.st.slsshh.llc.ah.p.pG..hYhpppphhppstpG+IsWs+TIpcspsllp....pssslYhchhs++ph.spschlptlathslppshpph..Galhsh..t..t..phsp.........spsh.hlph.LcpchsptFsDcchtLhp.shhs.alpppsp.hppsp....hhGTpsFphlWEchlcchh...................s.t.spp..............................phh.s+spWp........ttsp.p.p..tp.....phl.pPDhlhht.......pcp....h.a.IhDAKYYphsh...........p........hps.hPsssslhKQhsYsp..shtph................p.tplh...NsFlhPhpt..tp..........h...............................................................................................	0	7	10	14
+9396	PF09564	RE_NgoBV		NgoBV restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the NgoBV (recognises GGNNCC but cleavage site is unknown) restriction endonuclease.	25.00	25.00	32.70	32.70	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.57	0.70	-5.13	2	50	2012-10-11 20:44:45	2007-05-04 16:47:48	5	1	44	0	4	35	4	197.50	69	96.74	CHANGED	MIKLTAQQIFDKLLDEEKILSANGQIRFFLGDVDIIVKQKDVVGNIIQEWLGGWLRKREIEFDVSTNTQMPPDFFLNKKDRSRELLEVKAFNRNAsPGFDIADFKMYSDE.hhpP.h.sschh.hGYDMDDNGNVTIKDLWLKKVWQITRSMDGWAINhpsKK.........sW............Clcs..............................................A+ha	.............KLTAQQIFDKLLsE-KILsspGQI+FaLGDVsIIVKQKDVVGNIIQEWLGGWhcKRpIEF-susNTQMPPDFFL.NKKDRSRELLEVKAFNRNAsPGFDIADFKMYSDEI....IHKPYMLDVDYLIFGYD.MDD.N..G..NVTIKDLWLKKVWQITRSMDGWAINLQVKKGVVHKIRPGV..WYSIN..KKNMPMFECLEDFVSAIEETVYQNPATRHNASLWK+KFEEAYKKHYNRSISIPRWHEIAHKY.........................	0	3	3	3
+9397	PF09565	RE_NgoFVII		NgoFVII restriction endonuclease	Coggill P	anon	Bateman A	Domain	This family includes the NgoFVII (recognises GCSGC but cleavage site unknown) restriction endonuclease.	20.80	20.80	20.80	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.00	0.70	-5.47	7	72	2012-10-02 13:01:53	2007-05-04 16:59:06	5	2	66	0	17	148	64	252.10	24	71.27	CHANGED	at..hppuDcL.lhsGYlo.shulpclcpls-.php.hpIsLlsGMash-Ghsts.asshhcLpthhpcpshGsl...alhtshchHuKlYlahKc.tpsh.uhlGSANhss...suhhpcphE..sssspDs.s.spchht.lpss.l.php.sltsh.ph..........phlh-tss.hpshtshptlsppslphh.ppt....F.l.h......csst.............pSsLNh....u.sR....Gph..psRsh.Es.IplstcIsRp.........ssa..P......ppp.FpllTDDGahh.s+hsup.......ssKplsuhts............pplLG+al+sRL.hspGsl...pp..........lT+E.L	.......................................................................................................................................................................h.hhsGh.s...............................h.t.......pl..plhhGMh...Ghs.......hpth..p...l.....hptpth..tth...al..........hHuKhY.a..pp....t..h..t.uhlGSANhs.........s..p...pt.hE....hhh.h.s....t..........h....lpp...h.ph.t...l...p....................hh..p..tp....hpth.....thtt.l........p.l.t.......t.p.....h.....ls.h........cs..t..............................................................+SsLNh..h.u.tu.R.....G.h..hsRsh.Es.lhlsppIppp......................tha...P..................tpc.s...FsllTDDG...h.hps.+sstp..........sKshpopss.............phLGcW.l.+s+L...tts.h.................................................................................................................................................	0	7	12	14
+9398	PF09566	RE_SacI		SacI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the SacI (recognises and cleaves GAGCT^C) restriction endonuclease.	19.30	19.30	20.50	123.60	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.29	0.70	-5.51	3	10	2012-10-11 20:44:45	2007-05-04 17:00:02	5	1	10	0	4	12	0	348.70	27	95.43	CHANGED	MuITINHSsAppVL+cAaEcAup.oDDchpsQW.....lILuT+LpElss.R...TYpAALlTALLAKAsDsRVDPhuIpE+sssDsAYSARSLCHuVlVs.pVEtuFLEGsLGAsR.EPlNNpPFhRYspaSuI.pVcNK.uRcYLD+VLsALScIDpEchATTp..uaRALVAuLthTlsRTN+......................ssKEssAlGuAIVptSLluEpcuFVlpuH-VsR+hQAuuAuhLshsa.KE.Ilst+lNDPsRsFPhDIsVY...cDGssaLoIEVKDKslsapDLppuVSKAotuGIp+VlaLssA+A.TslsL....DcohAlERstsCtVpVsFS.VpoFs+sCFAlSPllusStl.hAF.cAIscpLIEIcV+-ssID	....tlsIs+.cpAccVLpcAacsAsppsD.shsspa......llpsspL..hss.+...Ta+YILlTALLAKATsscINPLsLQppusl-GAYDARSLCHKVlVP..FE+saLpsuLGuSN.EPFLNKP.ARascl..Sp....cNA.VRRGpD.c.lL.ptLsthc..hpssss..AFcuLssALhhtlppspc...............................tpphhhs.s.hIhphpLh.phppsal...lcspcs...GpphpAt..suusLth....ha...pE.....VtschVNp..s...Spc.suDIDVY........................c-cpllhoIElKDKsaotpDVpHAlcKsusuGhp+shFls.GP+A.splch....-cops..hppApppslhlhas.hppFs+.hhsh.sh.stpth.hsh...lhpphh-hp.pp..............................................	0	2	3	4
+9399	PF09567	RE_MamI		MamI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the MamI (recognises and cleaves GATNN^NNATC) restriction endonuclease.	25.00	25.00	122.60	122.10	18.80	18.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.03	0.70	-5.36	2	5	2009-01-15 18:05:59	2007-05-04 17:06:57	5	1	5	0	0	5	3	274.20	30	84.58	CHANGED	LGSLp.ppc..LlcDLaVDLht+.pV....WAAlTtQoAQschGYIuQalsSlVhG.PG..pGhRGK.....sD-hA-................GStVp.........uuANIptsDcs+W...lG..cDsEa..........tEhLt.PhhaYLll.c.pslpcPssIRhphWplDu.psG.hhsLh-ha.....sS+pGtsaN.......FpLh.Pl.............L.apshll.Dsplphtshst.p.s.HhPLs....PlT..uRopsLphGthtthssRL.....hNsuchVLhps..........D.sslhsulhtPhsshDhAshS.hto.-A.s-thS	.........h.toLEsS-p..LIK....DLYVDL+++lss....WStITsQTAQA+hGYIGQHLASlVTGhPGstSGARGcDLs..ssDhuEIKoC.RVDQLspCpsCGosVpthEppCPsCuSTNIcRcDDSKW..LlulRsDsEa..........-ElLs..Pc+aYLlLFDapDl..pDs..csIRIpsWcVDupEc.GhsaC.Ll.DYYh.NI...Kh.uS++G...APaNLaPapacFtLp+Pl.............LIFcusIl.sDs..pIpht....lhPs.p.sh+hPLs....Pls..uRspslphsthtth.sRL..............................................................pt..hh...................	0	0	0	0
+9400	PF09568	RE_MjaI		MjaI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the MjaI (recognises CTAG but cleavage site unknown) restriction endonuclease.	21.60	21.60	26.80	36.70	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.90	0.71	-4.72	7	42	2012-10-11 20:44:45	2007-05-04 17:08:48	5	1	37	0	16	44	4	169.30	31	84.26	CHANGED	s.llNhAsphhptshP+lVGthSELI+Ehp...s+ohc-W+EaYhp+..hp-pIsctscKlhhhlpphhpu.lpplccEslcpalc-LVIs+Ta-Ghhhp.csILpplAcc...hssphc.AssE.-cspslDGaI....tpIPlpIKPhoa.sppsplsE.hphphIhYcppcshhhl.hscsh	....llNhAsphhphs+PcsVGthSElI+Ehp..........s+ol......cEWcpaYhp+...............hsEslcchscKlashlpchh.....pu.lpploc-....DshpalcsLVIs+TasGhhhp.psIhppltpc...........hshpa..c.AssE.-cshsID..h.aI.....tthslQIKPhTY.......t.hsE.hph..h..ppppp.....h...........................	1	7	12	15
+9401	PF09569	RE_ScaI		ScaI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the ScaI (recognises and cleaves AGT^ACT) restriction endonuclease.	25.00	25.00	40.70	40.50	22.20	18.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.31	0.71	-4.81	4	14	2012-10-11 20:44:45	2007-05-04 17:09:11	5	2	14	0	2	13	2	172.00	47	93.08	CHANGED	SPYtuhsEEcW.plTcpLIp-aPLSt-hIlphVLuSWEsIFoS+hGs.thpIGpslFPsPQhhGhlLcsLIshcltst.ss.Wpu-psp.-KDlVhhhs-hYSIElKTSSsccpIaGNRSaG..pspcuh..KSKsGYYLsINFEKap-s.sLcP+IphIRFGWLDaoDWluQputTGQQASlssphtpsKLlsla	..SPYtslspc.WhuhTccLIcpHPLStcpIVplsLcSW-sIFoSplGs..hpIG+shFPsPQIhGhlLHtLIstplpsca.s.Wpu-csth-KDlVhIhschYSIElKTSScsc.IaGNRSYu..p.spsuh..KSKsGYYLsINFEKF..s..phcPcIphIRFGWLDaoDWIuQpAuTGQQARLsscs.psKLhhlY.....	0	0	2	2
+9402	PF09570	RE_SinI		SinI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the SinI (recognises and cleaves G^GWCC) restriction endonuclease.	20.10	20.10	20.70	99.20	19.50	17.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.36	0.70	-5.36	3	15	2012-10-11 20:44:45	2007-05-04 17:11:24	5	1	15	0	6	17	15	215.10	37	92.89	CHANGED	FlQNAAElAKpsMDsl-PSLSEKFTlVI+FLSDNP-usSshRGKc.RssVGs-EaIphLAQNFp-G.RcP+pPsPPoTIPDElVSVVLNVuF-lPpEpLN+IKEpHRLSMuAENIVGDLLERYLAEVLEPsGWIWCSGohVKAVDFI+pDsE.ssWtsLQVKNRDNTENSSSSAIRcGTPIKKWFRTFSK+cuTNWDNFPsphuucsLNEcGF+sFVEpYLccl	..........................................................................................................s..p.pL..tF..lhpaLsp.Pp.hS.hRuKp....p.pVhp..cEhlphhAppYacu.RpschPt..P...pTlPDEhVShlhp.hsashoppplppI+hpHphSMuAENhVGsLLERYLssVLcspGWhWCsGshVKAlDFlphssc.s.WhhLQlKNRDNTENSSSSAIRsGTsI+KWaRohS+ssp......T.......NWsslPp.hp....uhsLsEpsFhtFVcpYl.t.p............................................	0	2	5	5
+9403	PF09571	RE_XcyI		XcyI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the XcyI (recognises and cleaves C^CCGGG) restriction endonucleases.	25.00	25.00	46.20	45.70	18.80	18.20	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.90	0.70	-5.57	3	13	2012-10-11 20:44:46	2007-05-04 17:12:37	5	1	13	0	4	13	0	292.30	44	93.16	CHANGED	PsPcsQI-FutuL-cLRplaLQpALLcTV+chDIucLDcELuKYVPsuDLQpLApYGLRAEllFsVPsVLEANP+LIGYYRLLLGYSQKcFYstD+GLGhGsFKSMEcKGKIuKAtpPcIcDLClAFsASAStLLsGlGhlRISRELLDDLTLLTLGPQLRGGRNNslGhAGh+hVFEIIREIVAPAIsESc-ouIVLoNAAGRsVTIEFuuDPDIIIREKlcsp+aKNslAIEVKuGTDlSNIHNRLGEAEKSHQKARp+GFTECWTlVNsuNIDLVKARsESPTTD+FYpLohLsDKussEYADFRcRIlALsGIP	..................................P.PchQIsFh.tLcchRthhLQpALh-TVcchDIspLDcpLtcYVssucLtpLApaGLRuEllFsVPsVLcsNP+LlGYYRLLhGaSQKcFYsts+GhshGhFKSMEpKGphspsttsclpDLChshstsuStLLsuls...plSpcLLDDLTLLTlGPQLRGGtNNp+GssuhhhVFEIIR-IVup.u..h.sEs...cp.stIplssAsGRplhIEFAsDPDIlIREchp.ppa+NllAIEVKuGTDsSNIHNRlGEAEKSHQKA+tpsaTECWTllsVtplDh.hAppESPoTsRFYplotLs.psssEYtDFRcpllulsuIs.............................	0	4	4	4
+9404	PF09572	RE_XamI		XamI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the XamI (recognises GTCGAC but cleavage site unknown) restriction endonuclease.	25.00	25.00	43.30	43.10	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.69	0.70	-4.93	5	29	2012-10-11 20:44:46	2007-05-04 17:13:06	5	1	28	0	9	32	4	214.40	35	79.36	CHANGED	TuNLT..uI...TP-lL.csaPpsLs.sLRMoTuPPIAcDRLlGLAchS.sLVcSlE.cs+LPs+Mcut.LcpcLcKlssVIp+hlDPDlFsWhscGcsPTccERchAATIVADRLCGAlAsPIlRNAQERR......QLAsIKSWLcARGYTQlssuAu..lNSM..sPGTFoFRtNlsV....Gs+..VNIPVDAVVps+Du+ptthPhhIEAKSoGDFTNTNKRRKEEAsKhuQLplp.YGpplsh.sLFLCGYFcoGYLGYuAAEGLDWVW	...................hp..tl...pst.l..t.s.hls.tLRh.suPPIucDcL.slus.....lpshp....thL..p.ps......Lp+lhsllp+hlD.chFsWhttsttPospphc.AAhlsustLhuA.......R.ApE+R......Q.shlcpaLcshGasch.tsu.....hpsh..................PsshpFptps.l.......Gpc......sDlVlt.tcs+.....hhlEsKsusshTNosKRhpp-.Ashhsphhhp.aGpt.hh.shhLsGhFcst.Lt.ttupGlshhW................	0	0	2	5
+9405	PF09573	RE_TaqI		TaqI restriction endonuclease	Coggill P	anon	Bateman A	Family	This family includes the TaqI (recognises and cleaves T^CGA) restriction endonuclease.	25.00	25.00	44.80	44.70	19.10	17.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.78	0.70	-5.25	4	13	2012-10-11 20:44:46	2007-05-04 17:14:29	5	1	10	0	3	15	0	199.50	46	95.09	CHANGED	opAQcALEAFEcFLcuLDLESYppKYRPIKTVEQDLPRELNPLPDLYEHYWKPssssPpFPsFEEFF-pWW-KRLR..PLDEFIRKYFWGCSYpFVRLGLEARLYRTAlSIWTQFHFCYRWpASCpLpLpAu.ELDuQGIDALIp.s.p-p.lGIQIKKETYRSEARutNRFLRKpp.soALlElPYTLQo.EELpcKApRARocp..EsYpLWsKVApHL-+LPNGFVIFRESYVKclEsFLpcNAsTLoGLI	..............pcsLctFEcFLtuLDL-pYpp+hRsIKTVEQDLP+EL.PLsslYcaYWcs...p.pF.sFE-aF-paWc+......+L+......P.LspFI+KYFaG..CShtFV+hGhcARLYRThlSIhTQFHFCYhWps.C.....p.....L.Lpus.ELDtpGIDAhlp.h.pt..lGIQIKK.oYRpEA+stsRFh++pp..tsuLlElPYsl.s.EELpcKhtpsRscp...csYp..hchh.p+.h.+L.NGFVlFpEsYl+.l..............................	0	3	3	3
+9406	PF09574	DUF2374	Short_TIGR02808; 	Protein  of unknown function (Duf2374)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This very small protein (about 46 amino acids) consists largely of a single predicted membrane-spanning region. It is found in Photobacterium profundum SS9 and in three species of Vibrio, always near periplasmic nitrate reductase genes, but far from the periplasmic nitrate reductase genes in Aeromonas hydrophila ATCC 7966.	21.40	21.40	22.30	63.50	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.13	0.72	-4.34	11	107	2009-01-15 18:05:59	2007-05-08 12:46:36	5	1	106	0	12	42	1	42.00	78	97.19	CHANGED	MSTLESVIWHlLGYuAMPVIILuGFluVAsVSIhLLuhsKDK	MSTLESlhWHVLGYSAMPVIILuGFlGVAVVSIhLLuhTKDK......	0	1	4	8
+9407	PF09575	Spore_SspJ	Spore_SspJ; 	Small spore protein J (Spore_SspJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Spore_SspJ represents a group of small acid-soluble proteins (SASP) from Bacillus sp., which are present in spores but not in growing cells. The sspJ gene is transcribed in the forespore compartment by RNA polymerase with the forespore-specific sigmaG. Loss of SspJ causes a slight decrease in the rate of spore outgrowth in an otherwise wild-type background.	25.00	25.00	88.60	88.30	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.20	0.72	-3.76	3	23	2009-01-15 18:05:59	2007-05-08 12:52:21	5	1	23	0	5	12	0	45.90	79	96.88	CHANGED	MS.FFNKDKGtNSEKD+NsVcGALEDAGpALKGDPLQEAVQKKKNNR	Mu.FFNKDKGKpS-K-KNVIQGALEDAGuALKDDPLQEAVQKKKNNR..	0	1	2	3
+9409	PF09577	Spore_YpjB		Sporulation protein YpjB (SpoYpjB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These proteins are found in the endospore-forming bacteria which include Bacillus species. In Bacillus subtilis, ypjB was found to be part of the sigma-E regulon. Sigma-E is a sporulation sigma factor that regulates expression in the mother cell compartment. Null mutants of ypjB show a sporulation defect, but this gene is not, however, a part of the endospore formation minimal gene set.	20.40	20.40	20.40	22.30	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.42	0.70	-4.79	10	157	2009-01-15 18:05:59	2007-05-08 13:35:37	5	2	156	0	27	110	0	227.20	45	87.38	CHANGED	uhcELscLSDslLQLsKpp+YEEAlQVLpYFpcpFhus-hcppp..lTssplRplTluY-cAl+uLpppchscpEKl+ssspFRLllDAlsScpcPLWsphEcPlMcuFushKcAspppDspsFpcphNpFloLYslIYPSLpIDlssspLppVssHlshlEphc..phopsopp-+LsllcpDLpslFDpVccD-ADPSLLWVIloTGGIIlhTLTYVGaRKYKuEKcKcKsR	............................................................pWpELssLhD-uLQLVKcsc.EcAlQVLpaFS-QFhhpssc..ccp..lTs-plRlISLuY-cAppSLsppslscp.Klcslh.tLpLAVDA.sSKaQPLWhEhEtplM-AFSphEKAhpKc...Ds...spFppoLNsFLpcaslIYPSLhIslPEs-lQRVsuHlSY....L-.ch.c.s.sh.Lc.s.cus....phQ.L.ull.+uDLQ+lFcsVK.......KD.......Eh....s......P......SL.........I......Wh.MshTGGlIlhTLTYVGWRKYKGE+EK+Ksp...........................	1	6	17	19
+9410	PF09578	Spore_YabQ		Spore cortex protein YabQ (Spore_YabQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This protein is predicted to span the membrane several times. It is only found in genomes of species that perform sporulation, such as Bacillus subtilis, Clostridium tetani, and other members of the Firmicutes (low-GC Gram-positive bacteria). Mutation of this sigmaE-dependent gene blocks development of the spore cortex. The length of the C-terminal region, which includes some hydrophobic regions, is variable.	21.00	21.00	22.50	22.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.52	0.72	-4.03	38	379	2009-01-15 18:05:59	2007-05-08 13:55:22	5	1	375	0	85	295	6	79.20	32	46.51	CHANGED	hlsslhsGhhlGhhaDhY+..hh+phh+hp.+hhshltDllFWl...ltulllFhhLhhsN.GplRhYlaLullhGhsl...Yhtllup	..............hlhhlhhGhhlGhsaDhYp..hhhpth.....cpp...+hh..shlpDlLFWl...ltulhlFhhLhhsNpuclRhYlaLullhGhhh...Ytphlp.............	0	45	70	75
+9411	PF09579	Spore_YtfJ		Sporulation protein YtfJ (Spore_YtfJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this family are encoded by bacterial genomes if, and only if, the species is capable of endospore formation. YtfJ was confirmed in spores of B. subtilis; it appears to be expressed in the forespore under control of SigF.	25.00	25.00	25.10	25.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.81	0.72	-4.13	71	712	2009-01-15 18:05:59	2007-05-08 14:01:05	5	1	496	0	166	461	6	87.30	40	62.67	CHANGED	lcssD.slIlPlu+VuFGFuuGGu-hpspp.................tppt..........hGGGuGuGlulpPlAhLVlp.s.....spl+llsl.spps..hl-+ll....-hl.Ppll-+	..........lpssDGslllslS+V..uF..GFuAGGS-apssp....................t.ttps.............FGGGSGuGVSIsPlAFLVls.s.....ssV+lLpl..spss....hh-Kll.....-hsPphl-K.........................	0	73	135	147
+9412	PF09580	Spore_YhcN_YlaJ		Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidic, 40-residue C-terminal domain.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.02	0.71	-4.16	52	715	2009-09-10 23:13:51	2007-05-08 14:11:15	5	3	229	0	145	527	0	161.00	19	84.30	CHANGED	hhhhhluGCsssppsp.tt...............................................................................................................................................sstsst.thsp..hphpp.tsppt............htstpcpclAcclschss.plspVccAsslVs...........................................sppAlVulchp.t....t.......spsc...pl+ppVpcslcshssphppVhVouDs-hhpRlcshuppl.psGpsh..pshhp-lsphl..p+lhs	..........................................................................................................................h......................................................................................................................................................................................................................................................t..t....tp......hphpphttpp.........................pstpsspchAcplsshst.plssVpcusslVs...........................................sp....pshVulcsc.tp.....p.............................................stsc..pl+ppVtcplps.sP...p.hslhVosD.chhpclcplsppl.pp.s..p.sh...st.h.tpplstlhtch................................	0	50	104	116
+9413	PF09581	Spore_III_AF		Stage III sporulation protein AF (Spore_III_AF)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family represents the stage III sporulation protein AF (Spore_III_AF) of the bacterial endospore formation program, which exists in some but not all members of the Firmicutes (formerly called low-GC Gram-positives). The C-terminal region of these proteins is poorly conserved.	21.50	21.50	21.70	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.05	0.71	-4.43	40	411	2009-01-15 18:05:59	2007-05-08 14:19:16	5	1	379	0	93	314	6	174.90	20	89.74	CHANGED	llhllhsshlEhLLPsush+KYl+hVlGLlLllllLsPllpLhp.p-hshththhpp.......pp...ppphppptcchpspppshll-p....hpspLcpplccplc...pphshphtclplphsps.pptt.......pIpplsltlpp...tp.t........................................................pVc.lpIst..................tp.stppttpspptpclcphlup....hapl.sp-pIpVth	..................................................hhllhsshlchlLPssshpKYl+hlluLlLllllLsPlhpl...hp.pc.h...s..h....h.t.....hsp.......................tttt.p..pp...l.p.pp.pcch.pttp..c.shslcp.....htpphccplppthp........pp.hshph.clpl.hs....psttp.p............plpp.l.ltlppt.t.tp..tt..t.........................................................plc.lplst.................................................t.t..tt.pt.t.c....hpphhup......hhpl.t.cpIpl.................................................................................	0	47	76	82
+9414	PF09582	AnfO_nitrog		Iron only nitrogenase protein AnfO (AnfO_nitrog)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry include Anf1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) and AnfO from Azotobacter vinelandii. They are found exclusively in species which contain the iron-only nitrogenase, and are encoded immediately downstream of the structural genes for the nitrogenase enzyme in these species.	23.90	23.90	23.90	57.20	23.30	23.50	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.96	0.71	-5.18	14	61	2009-01-15 18:05:59	2007-05-08 14:24:52	5	2	51	0	39	60	0	200.20	27	92.49	CHANGED	hcIAVhlsppGphsohh-sGhltVYpcssspWplt+ch.hs.lssspulstl+ttlsshlspLscC+lhlupsspGlsYuhL.-chuhplWchpGpsh-hLDtVhccEp-pt.cptt...............................tssshshshPlchG.s...GcaplsLpcl.ppsscloSKQlLlPFLcsssFpcL-llCsHlPpWhsp-lsthsLch-s..pphs+pslp	...cIAValscpGpssoh.csGh.ltlap+.psspWphhcch.hp.l.ssstulsplRpphppllptLscC+lhlupplpGlsYshL.-chGhslWch.pGps.-..hLDtlhccEpcptpptt.................................ssshsh.tPhchs..s...GpaplsLpcl.t.psssloSKplLlPFLcpssFppLEllCsHlP.Wh-pcltthsLphch..pt.......h............	0	17	30	34
+9415	PF09583	Phageshock_PspG		Phage shock protein G (Phageshock_PspG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This protein was previously designated as YjbO in Escherichia coli. It is found only in genomes that have the phage shock operon (psp), but it is only rarely encoded near other psp genes. The psp regulon is upregulated in response to a number of stress conditions, including ethanol, expression of the filamentous phage secretin protein IV and other secretins and heat shock.	25.00	25.00	55.60	55.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.28	0.72	-3.91	13	608	2009-01-15 18:05:59	2007-05-08 14:26:17	5	1	604	0	44	195	2	64.50	71	79.78	CHANGED	MlELlFllsFhlsLllTGlSllGllAAlsVAhslMhluGMhulVIKLLPWLlLhllslWlhRshp	.MLELLFVlGFFlMLMVTGVSLLGIlAALVVAT.AlMFLGGMLALMIKLLPWLLLAlAVVWVIKAl.t..	0	1	7	25
+9416	PF09584	Phageshock_PspD		Phage shock protein PspD (Phageshock_PspD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are phage shock protein PspD, found in a minority of bacteria that carry the defining genes of the phage shock regulon (pspA, pspB, pspC, and pspF). It is found in Escherichia coli, Yersinia pestis, and closely related species, where it is part of the phage shock operon. It is known to be expressed but its function is unknown.	25.00	25.00	27.70	29.20	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.16	0.72	-4.27	7	520	2009-01-15 18:05:59	2007-05-08 14:33:02	5	1	516	0	28	113	1	63.30	79	86.29	CHANGED	t+s+sG..LKhhuKlhlhsALpYGPAGsAGWhVKoVuRKPL+hLLAhsLEPlL++hhs+lutpahp	................QKVKPG..FKlAGKLVLLTALRYGPAGV...AGWAlKSVARRPLKMLLAVALEPLLSRAANKLAQRY..Kt.	0	1	5	17
+9417	PF09585	Lin0512_fam		Conserved hypothetical protein (Lin0512_fam)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a well conserved motif GxGxDxHG near the N-terminus.	23.40	23.40	23.50	24.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.43	0.71	-4.51	22	222	2009-01-15 18:05:59	2007-05-08 14:40:49	5	3	169	0	69	202	119	110.20	39	85.68	CHANGED	pphhlEhGhGsDlHGQDhTKAAtRAV+DAlp+sSlsuhhc.hhsh.shspMpVpVclGVscP..-pVDt-tltshlPaGp.ssVpllpGGL......sltchss.s-shlIAsAAVpVu	.......hlhlEhGhGsDlHGQ..DhTKAAtRAV+DAIp+NSlsultp..h.....lsh..s...hp.sMhVplpluVs.......ps..-plDp-tl+ullPYGp..solcshpGGh.s..uhtltchs-ts-.hhIssAuVpV.........................	0	25	51	63
+9418	PF09586	YfhO		Bacterial membrane protein YfhO	Coggill P	anon	Pfam-B_2727 (release 21.0)	Family	This protein is a conserved membrane protein [1]. The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system. Some members of this family have been annotated as glycosyl transferases of the PMT family.	28.50	28.50	28.50	28.50	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	843	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.37	0.70	-6.52	56	1820	2012-10-03 03:08:05	2007-05-08 15:29:27	5	4	1236	0	257	1471	211	637.40	21	83.13	CHANGED	u.hllPhllhhhhhh.....hthhshuspslhssDhhpQYls....Fhthhpptlh......sssshFYoastGLGushhuhhuYYl.hSPhshlhhhFs..............hpphspuhhllsllKhulhGLohhahhpphh........tph....hhslh.....huhsYuLsuasls.phslhW...hDshIlLPLllhGl-+llcpp+hhhahlslulhl.lsNaYhuYMhslFhhlYhlhph...h.......pshpphh.....pthhpahhsSlLushhSulhllPshhslhs.spps.sp...sh.hthphshhchhs+hhhGsashpph.......s.laluhlshlhhlhaFht+phph+h+lhhsllhhhlllShhhphlshhWpGhptPsha.aRaualhuFhhlhLuupslp....phpph.........hhphhhshhllhtlhh.hshhhp.ppt...phhp.....h...................................................slhhlllhhlllh.hhh..........tph.hhhhhhllhlhhhh-hshNhhhslsphs....hsspp.asshhpshpphhphhp....ppsss.haRl-phhsps......t..........N..-shhhsYpGlStaSSlhspsh.shhs.....slG...tssssphphtssohlhDuLhulKYhls............................................pspphplYcNp.sLPluasssshh......pchchpp.....tssls...pQsthLpulsspst.............................................phFps.........................p.sphphpssptts..shht.st......................spstssslphshs.sssssshYlphs.........................................s.sppshslpV.Nspshppp...............pstlhsluhpscsp.plplsl......hsps....phplsphplhshsh.pshppshpplpp.pthphtphp...ssplpuslss..pcsshLhhoIPYs+GWpsplsGKplphp+..sp............ssFhu..lslspGppplplpYhPshhhhG..lllS	.......................................................................................hlshhlh.hhhh.......t.h..h.....u...t........h......s.Dhhp....Q.hh.........a...h.hphh...........t..p...h.......as...h.s..ul.Gh.sh.ht........uYYh..hu.h....l.h....hh...............hp.hs.shhhh...hhl+hhhhhhshh.h.hphhh...........................th............h.hhhuh.Yuh.shhh...............a......hss.hhhhPLhlh.ulch.h.h............p....pp....+......h...h...hh....h.s.....h...hhh...h.p.....N......a......Y.....h.....ua..hhs.....lhhhhahlhth....................................ph..hp..hh......pthh..hhhhshlu....sh.uhhhhhPs...h..sh.p.ptp.t.......................................................................h.........h..........p..h..p..........h.....h.............h.......................s.........................................h..ah...hh........h.s....h..lh....h.hh.....h..h..........p......hp..h..h..h.......hhh.....hh....h...hhh.h.hh...s.......h........h.s.......ha.......p...uh..p.P.t...................hR...as...alh.sh.h.h.hsh.hhp..........phpph.....................hthhh...hhh..hhhhh.......hhh...h.h.....t............h.........h.h.h...............................................................sh...h.h.h.h.hhhh.hh.h.h......................................................h.h.h....hh..h..hhh.h.h..........h.......h.....s.................hpth..................p.t.h..tp.....h....t..........t.......t.h..............................ttt..h.Rhp...h.....t...........................N....sshh.ht....atuho....asSh.hstt.....p.hhp.............ths.........tp.s...ht.......s..sp.....h....slhslph.h.........................................................................................p.t......ph.hhpNp..t.hshu.h.hspp...h...........p.p...p.ht............sht.ppt.t.hhpths..p....................................................................................hhp.......................................p.t..ht..t..t..............................ttt.hthp.h.......hp.....t.....tph..ah.h..............................................................................tpthpl...l...st...p...............................hhsl.s........t...tp.phplph.............tt....thpht...thh....t...s....pt.hp......pthpph.pt............h...p.......ph........ps.plthshss..ppst.....hlhh.o.l..P.Y..sp.G...Wpsh...s.G.c..p..lp.hpp..sp............tshhu..lpls.t.Gp.p.plphpahP.hhhhGhhho.....................................................................................................................................................................	0	106	190	230
+9419	PF09587	PGA_cap		Bacterial capsule synthesis protein PGA_cap	Coggill P	anon	Pfam-B_1441 (release 21.0)	Domain	This protein is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.63	0.70	-5.02	181	2048	2012-10-02 19:15:56	2007-05-08 15:48:07	5	29	1542	0	483	2755	332	235.10	26	60.66	CHANGED	slshsGDlh.hs........psh.p.h..t..................................shs.ha.ttlt.s...hlppu...D.lslsNLEssl.........................................ssssp...shss..h.....htapsssph.sssLppsGh..c...slsl.ANNHshD....aGtpGltcTlp...tLc.psG...lthsG...suts.tpupp...hlhph........pGh+luhluas............................................................................................................ppltpc.......lpps+...p............sDlllVshHW..G....tE........hptt...........P.sspQpp............hA+thlD.u.....G.ADlllGpHPHVlpshE.ha..........csp.......................hIhYSLGNF.lhst	.............................................................................................................lhhsGDhh.ht........t.t.h.t.h..t..........................................shp..a..ttlt......hl..ppu....D..l.s.hsNhEssl.............................................sspst....hsth..........hapsss.ph..hp..sl.......p.s.s........G...a.c....slsl.ANNHshD....hGh...p...Glh.s.T.lp............tl.c....p....ts...............lth..h.G.............shp....s........t...t....c..s........p.p..s..........hl.h.ph............pGh+luhluashsh.ssht.sh....s....t............................................................................................................................................................spltpp...lccs+....p..........puDl.llVhhHh.....G.......sE.........................a..p.p...........................P...sppQpp.......................................................hu+th...l.-..t........G...A...Dl.lhGpHPH.V..l.p.s.hE.hh................................ptp.................................hI..h..YShGNFl.s....................................................	0	197	343	427
+9420	PF09588	YqaJ		YqaJ-like viral recombinase domain	Coggill P	anon	Pfam-B_3587 (release 21.0)	Domain	This protein family is found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms part of the two-component SynExo viral recombinase functional unit [1].	21.10	21.10	21.10	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.06	0.71	-4.24	97	1553	2012-10-11 20:44:46	2007-05-08 15:50:07	5	18	969	13	375	1400	442	140.60	24	46.91	CHANGED	-WhphRptt........l.suS-sus.................................................hhG.hs..h.....ps.shplhhccssp..............................ptspsht....hGpphEshstphappppG..........hplpt.......thh........p.shhtAShDGhs..................................................................................................................................thlEhKsst....t..hht....................ttl....PptYhsQ.....lQtthhV........o.utc	...............................................................................WhthRhth..............l.suS-sts.....................................................llu....hs...............ts....hhphhh.ph.hsp.............s..........................................................................psp.sht....h.GpphE..........s..ut..........p....ha..ph.p.pu.........................hplpc..............p.shhh+...........spp.h...h.u....u.osDGls.........................................................................................................................................................sshLElK..ssh...............s.p..hhph..pht....................................tl.................ttYhsQlQhphhlos..t............................................................................................................................................................	0	189	280	336
+9421	PF09589	HrpA_pilin		HrpA pilus formation protein	Coggill P	anon	Pfam-B_3574 (release 21.0)	Family	HrpA is an essential component of the type III secretion system (TTSS) which pathogens use to inject virulence factors directly into their host cells, and to cause disease. The TTSS has an Hrp pilus appendage for channelling effector proteins through the plant cell wall and this pilus elongates by the addition of HrpA pilin subunits at the distal end [1].	25.00	25.00	26.00	25.90	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.82	0.71	-3.66	6	71	2009-01-15 18:05:59	2007-05-08 16:00:00	5	1	55	0	4	39	0	119.80	48	98.42	CHANGED	M........................s.hppLsshGptslNslGGA....................................hQGlNslsSusshpsNll...................usT..GsopSscAppcuhucu.......................................DAsuA+L..........................................................uhQucEstK+pp.ssLsAhpAu+EDuoNKKISuTtpNApGIsY	....................h.....slhSSLosAGpulVNslGGA....................................hQGlNoVcSuADRphuLh...................psT..GSoDSlDAspsuluKG.......................................DAcuAcL.........................................................puhusEEsuhhREpSMLAGFEstKEsLoNQIVAuKIcNuV.VQF.	0	0	1	3
+9422	PF09590	Env-gp36		Lentivirus surface glycoprotein	Coggill P, Bateman A	anon	Pfam-B_3269 (release 21.0)	Family	This protein is found in feline immunodeficiency retrovirus. It represents the surface glycoprotein which is found in the polyprotein C-terminal to the Env protein.	19.30	19.30	19.90	21.70	18.70	16.70	hmmbuild  -o /dev/null HMM SEED	591	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-13.04	0.70	-6.31	5	1139	2009-01-15 18:05:59	2007-05-08 16:06:50	5	2	10	0	0	929	0	233.30	65	86.41	CHANGED	FuQNRQWIGPEEAEELLDFDIATQloEEGPLNPGVNPFRVPGIT-pEKQ-YCsILQPKLQELR-EIpEVKL-E-NAGKFRRlRYLRYSDEpVLSllYLLl.GYl+YLhsRNKLGSLRHDIDIEss.scEpFsK+EKGsTlNpKYCRlCCIGsssLYLlLFIGIGlasGossAQVVWRLPPLVVPVE-oEIIFWDCWA..PEEPACQDFLGAMlHLKAshNISIQEGPTLGpWAREIWATLFKKATRQCRRG+lWRRWNETITGPhGCANNTCYNlSVlVPDYQCYlDRVDTWLQGKlNISLCLTGGKMLYNK...-TKQLSYCTDPLQIPLINYTFGPNQTCMWNTSLIcDPEIPKCGWWNQsAYY....NSCKWEQsDVKFQC........QRTQSQPGoWlRsISSW...KQRNRWEWRPDFES.EKVKISLQCNSTKNLTFAMRSSuDYu-VsGAWIEFGCaRNKS+pHopARFRIRCRWNsGoNTSLIDTCGscQNVoGANPVDCTMpuNTMYNCSLQcGFTMKIEDLIVHFNMTKAVEMY............NIAGNWSCsSDLPouWGYMsCNCTsosSo....hsKM+CPsc-GILRNWYNPVAGLRQALcKYQVVKQP-Y	..............................................................................................................................................................................................................................................................................................................................................................................................................AYY......NuC+WEps.sVpFQC.........QRTQSQPGoWhRsISSW...+QRNRWEWRPDFES.EKVKlSLQCNSTKNLTFAMRSSuDYG-VsGAWIEFGCHR..NKS+hHo..-ARFRIRC+WN.GsNsSLIDTCGp..s....NVoGANPVDCTMtAspMYNCSLQcGFTMKlEDLIhHFNMTKAVEMY............NIAGNWSCpSDlPtsWGYMsCNC..T..................KMtCPpppGIlhshYssshh.h.tLt+Y..lVKQP-Y................................................	0	0	0	0
+9423	PF09591	DUF2463	UPF0328; 	Protein of unknown function (DUF2463)	Coggill P	anon	Pfam-B_3132 (release 21.0)	Family	This protein is found in eukaryotic, parasitic microsporidia. Its function is unknown.	22.00	22.00	55.00	54.50	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.48	0.70	-4.74	23	38	2009-01-15 18:05:59	2007-05-08 16:07:07	5	2	2	0	34	38	0	199.70	39	75.93	CHANGED	FPhhhYhIhsKDsF-ps.hLRFIslLhPaSYSAlQahhLLaoN...W+uspKPEshLaphLYahLNlLLlsFulISILSIIshsl.....scWpss-s.hhaSllLPSFhlssTYLLSTSCsLVPGpIuFTDTGIslLIDlLILLs.llsllh..hhccsc....Yh.a.ulhSslLlLl....RhL+E+ahP..SccS..........u.PousWRVulhllILlLushlYshhshssl	....aPhhMYhIhsc-pFccs..FLRFIslLhPhSYSAlpahhLlaoN...W+uppKscshLpshLYahLslLLluFulISILSIlsFsl.....s.cWcs..scs.hhaSl.lLPShhlsssYLLSTSCsLlPGpIuFTDTGIslLIDlLILlsslssllh..hhccsc....ah.ahullS.lLlLl....RlL+E+hsP..sccS..........s.PossWRlulFllILlLuhhlYshhshhsh....	1	34	34	34
+9424	PF09592	DUF2031		Protein of unknown function (DUF2031)	Coggill P	anon	Pfam-B_2630 (release 21.0)	Family	This protein is expressed in Plasmodium; its function is unknown. It may be the product of gene family pyst-b [1].	20.70	20.70	21.40	21.60	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.66	0.70	-5.20	44	121	2009-01-15 18:05:59	2007-05-08 16:18:06	5	3	5	0	117	121	0	178.40	43	83.33	CHANGED	RlsILK.YVhFS.......IlICSF...EYuKN...ELYhlN......-RsIhLERNlINFRNNRILADsDNpFDLN-FYQSTLSLANQhN-hs-....Ds........cEItaLRNhIDSHIKKHKEsNTL.DLpNVD.pKTKKLIscL+KELEEl......KKElDN..KpNuELuIQPIpDKpIhKKDENsSVSEcEsF+QLENp.s.lt............E.NcIs.SSsphhc.Khpp+h+..Kttpphlhps..lhhlshshslh.lsG....hh.lhhllls	.....................................thhp.hlhas.......lhlh.F...casp.s.....................ELa.hs......tttlhhERNlIsFRNNRILussDNpFDLNpFYpSTLSLssQhs-hs-........ss.......cEIhhlRNhIsS+IKcHKcssT..sLpNlD.pKTKKlIpcl+cELEEl......KKElDN..htN.sclsIpsIpsKhIhKKscNssVSEp.EsapQLcNp...........................................c..pht..s....p.p..pchp..+...thhhp...hhhh.hh..h.h..h.s.h.h.hhhh........................................................................................	0	0	69	117
+9425	PF09593	Pathogen_betaC1	Phage_C1; 	Beta-satellite pathogenicity beta C1 protein	Coggill P	anon	Pfam-B_991 (release 21.0)	Domain	Cotton leaf-curl disease - CLCuD - is of major economic importance in cotton-growing areas of the far-east. The infectious agent appears to be a single-stranded DNA molecule of approx 1350 nucleotides in length, which, when inoculated with the Begomovirus into cotton, induces symptoms typical of CLCuD. This molecule requires the Begomovirus for replication and encapsidation [1]. DNA beta encodes a single protein, betaC1. The intracellular distribution of betaC1 is consistent with the hypothesis that it has a role in transporting the DNA A of Begomovirus from the nuclear site of replication to the plasmodesmatal exit sites of the infected cell. The DNA beta-encoded protein, betaC1, is the determinant of both pathogenicity and suppression of gene silencing [3].	25.00	25.00	46.80	43.60	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.53	0.71	-4.38	36	475	2009-01-15 18:05:59	2007-05-08 16:19:52	5	1	198	0	0	438	0	116.10	44	96.96	CHANGED	TIpYsNpKGlcFlIDVRLpppppIhVpIplhST+SPsLsKpcahIPYsHsGIIsP....FDFNulEEuI+shLclMY+-Sslp-F+pEDMl-sIDIlMMccAsVl-Icls-cYcVpspssV	.............TIpasNp+GlcFh.lDV+lp.-sppIhVclclhST+..SPuLsKpcFhIPYsapsIhsP....FDFNul..E-uIpshlchhYpcupIpEh+pEDhVchlDIlMhcpssllsh-Vh-.YslspphsV.................................	0	0	0	0
+9426	PF09594	DUF2029		Protein of unknown function (DUF2029)	Coggill P	anon	Pfam-B_1780 (release 21.0)	Family	This is a putative transmembrane protein from bacteria. It is likely to be conserved between Mycobacterium species [1].	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-12.03	0.70	-4.87	135	2105	2012-10-03 03:08:05	2007-05-08 16:20:35	5	21	708	0	676	2166	215	239.00	18	52.91	CHANGED	ah.YPPhssllhsPh.u...........hLs.....hssuhhlahhhs...lsshhhs.lthhhphh........................shhhhshh.hhlshtsl.hsshshGQhshllhshlhhshhhhh...tt.......t.h....................h.uGlhlGLusslKlh......Phlhsl..hhLh....p+c........a+uhhsu.sssssshssl..uhhhhs............sshthahp.hlhts.ptl...........htt.ssto...hsuhlut...hsh..............hhhhh...............shhs..sshshhhhhthh.........ps.sphtths...ssuh.h.......lLsSP	...................................................................................................YsPhssl.h...h.h.sh.s...............................h.ls................hsssh..h..l.h...hhhs............hhsl...h...hs...lhhh.h.ph.hsht........................................hhhhs.h.h.h.h.hh.s..h...pPl...htsh.sh....u..p..h..s.h...lhhslshhshhhht.........pp.......................p.h..............................h.uG.l.h.l.G.Lu....su..hKlh................Pslhhl......hhlh.......................s+c..........................................h..+s...hhtu....sssss.shssl......shhlhs........................................................p.s....h.p..h..ahp....hhhtt..tth........................hph.tspu........h.t.s..hhs.p.....hsh..................................................shhhh.hh.......................................shhs........hshsshhhhthh...............pp...tphht.hs.........hsuh.h.....hlh................................................................................................................................................................................	0	204	477	607
+9427	PF09595	Metaviral_G		Metaviral_G glycoprotein	Coggill P	anon	Pfam-B_922 (release 21.0)	Domain	This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated [1].	25.00	25.00	56.90	56.80	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.38	0.71	-4.65	6	400	2009-01-15 18:05:59	2007-05-08 16:31:51	5	1	2	0	0	422	0	170.10	51	88.21	CHANGED	LIGlTsLShALNIaLIIsYshpKNhocoEHpss.PPsEsSKcTshsssssPsTsPNsQpsTQ.oTEsST..sAostup.cTtsTsTPDsTsp.posD+HTT.PpuopspTopsspcKpsoRsso......+ppos.pToTtAspsssTsppoSsG+csTTTSspPcosuTTQspEpTopsss.oSsSpt	..LIGlTsLShALNIaLIIsYsh..+shocsEHpss.PPsEssKETsohshssssTpPNsQpsTQ.oTEssT..sAsStupscTEsTsTPDsTsp.posDcpTT.PppopppTspTspcKpsspsso.......+ppos.psoTtAsppssThppoSsuccsoTTSspscsusTTQsp-pTspsss.uS.st.........................	0	0	0	0
+9428	PF09596	MamL-1		MamL-1 domain	Coggill P	anon	pdb_2f8x	Domain	The MamL-1 domain is a polypeptide of up to 70 residues, numbers 15-67 of which adopt an elongated kinked helix that wraps around ANK and CSL forming one of the complexes in the build-up of the Notch transcriptional complex for recruiting general transcription factors.	21.00	21.00	22.40	35.70	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.98	0.72	-4.17	6	82	2009-01-15 18:05:59	2007-05-08 16:39:24	5	2	56	4	56	113	0	60.40	48	8.06	CHANGED	PphHSsVVERLRpRIEsCRRHHsoCEuRYppupsEphEhERccTlsLhpRslcu+uKRuAp	....P.hHSsVVERLRRRIEsCRRHHssCEsRYEpspsEphEhERpcThsLpQRsLcuKAKRuu...	0	14	19	36
+9429	PF09597	IGR		IGR protein motif	Wood V, Coggill P	anon	Manual	Domain	This domain is found in fungal proteins and contains a conserved IGR motif. Its function is unknown.	22.40	22.40	22.50	22.90	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.56	0.72	-4.06	18	185	2009-01-15 18:05:59	2007-05-08 16:50:16	5	7	159	0	138	171	1	56.80	39	30.06	CHANGED	lpsFLptIGRsssc+s-.pFEs.W....-cLFp..hsoppLK-hGl.ss+pRRYILphtc+aRpG	....................psFLshIGRsh..pp+ss.Kh..ps..W....cpLas..hsStpLK-h.GI..Ps+pR+Yl...Lcatc+aRpG.........	0	40	81	117
+9430	PF09598	Stm1_N		Stm1	Mistry J, Wood V	anon	Pfam-B_39435 (release 21.0)	Family	This region is found at the N terminal of the Stm1 protein.  Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein.  It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with CDC13 [1], and is known to associate with ribosomes and nuclear telomere cap complexes [2].	21.80	21.80	22.50	22.50	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.86	0.72	-3.28	24	195	2009-01-15 18:05:59	2007-05-09 10:35:27	5	3	137	2	126	189	0	68.20	35	20.52	CHANGED	NhaDLLGNDs............E.DsstsstsPs.+tlsKpsspstKt-............sP...PsussPs.........pup+stspsoG.NEuAhR	........N.FDLLGsDs............E.Dssphs....ssss.....+tl....sK....s.s......spstKts.............ss..p.P..sps.sPsttt...............+ss+s.ts.pssG.scsuh+...............................................	0	22	67	105
+9431	PF09599	IpaC_SipC		Salmonella-Shigella invasin protein C (IpaC_SipC)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of proteins associated with bacterial type III secretion systems, which are injection machines for virulence factors into host cell cytoplasm. Characterized members of this protein family are known to be secreted and are described as invasins, including IpaC from Shigella flexneri and SipC from Salmonella typhimurium. Members may be referred to as invasins, pathogenicity island effectors, and cell invasion proteins.	25.00	25.00	26.90	25.80	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.78	0.70	-5.42	5	167	2009-01-15 18:05:59	2007-05-09 11:34:12	5	2	152	0	6	107	0	338.40	53	86.65	CHANGED	+ssspuLhps-uAhushs.....................AtspslLsohLsDctpsssLspslphhsuspls+lssh....VQ+cLcpcuAclssGpshDISu................hSocAsuLlhu.lssLMusLspADs+LuoKLSLlSFDATKoAAuShlREGhAsLSSSIsGuAsQluITGVGAKpphsGLssc+GALK+NLsstscLssEu+slpLsLNpQNsssLuA...DtlppltlK+ssu-usKplsc.p...................lssuNcplSsEHcusLupcstulpc+I-hcppsa-psplKAQppQppGDtlMcsSssAGNIuuuSGpYAustEcuEQpISQuuu+sApoASs-o+EuS++ocplIQElL+sl-SIsQS+o	...................................................................................+.suchuLu.sLuA.APsV....................LspsssslToaLp.sshQsochsQ-lNtLAsslTsKss-s....VQTpL+EppAEV......GchhDISu................MSSsAVALLuA.AssLMhoLNQA....DoKLSGKLSLVSFDAAKosAuSMhREGhsuLSGSISQSALQLGITGVGAKLcaKGLpsERGALK+NuAKlcKLoTEu+uIKssLNGQNol+LGA..sDuLKolshK+T...GsDuTKsLs-soh................htIKcSNKplSsE...HQAlLSKRlE.SlE.ScI.cL.EQsTMDhT+l-ARKMQMTGDLIM+sSsolGsIAGASGQYAAsQERSEQQISQsNNRVASTASDEARESSRKSTSLIQEMLKoMESINQSKA................	0	2	2	4
+9432	PF09600	Cyd_oper_YbgE		Cyd operon protein YbgE (Cyd_oper_YbgE)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a small protein of unknown function, about 100 amino acids in length, essentially always found in an operon with CydAB, subunits of the cytochrome d terminal oxidase. It appears to be an integral membrane protein. It is found so far only in the Proteobacteria.	22.00	22.00	27.30	26.90	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.80	0.72	-3.82	21	679	2009-01-15 18:05:59	2007-05-09 11:41:23	5	1	674	0	64	249	4	80.50	64	85.54	CHANGED	..LR........uLSllLAlhlsuhlhWsPstaAsphuuhsshhu.hllWAlCuuhlaGVGFcP+phlWphlF.uPhhuhsILhhslh....aah	.........................PLRALSFVMAllLAGCMFWDPSRFAA+TSpLEIWHGLLLMWAVCAGlIHGVGFRPppVlWQGI.F.CPLLADIVLIlGLIFFF.h....................	0	3	22	44
+9433	PF09601	DUF2459	Chp_urease_rgn;	Protein of unknown function (DUF2459)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This conserved hypothetical protein of unknown function is found in several Proteobacteria. Its function is unknown and its genome context is not well-conserved. It is found amid urease genes in at least one species.	21.80	21.80	23.40	24.10	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.06	0.71	-4.57	33	265	2009-01-15 18:05:59	2007-05-09 11:44:24	5	1	262	0	60	200	49	167.20	41	75.35	CHANGED	IhllssslHTDlllPhss....hhthhthhsssslshstsss.p.alshGWGs+sFYhsossas-lsstsslcAl.ssss..oVl+Vsshsshs......ssssltplslupspappLhshlpsoFttstsuts..l.ssuasss-tFatApGcashhpTCNsWoussL+sAGlchuhWs.Phshul	............................IYllSpGhHT.sIlhPscss.............shshs..plcpc.as.pt...p.ahplGWGD+uFYts....p-losuhsLpAhFhsou..uVhHlssaushPc..........suu-l+sL...hLpssQhssLhcalucSFsRDtpGs.lIsl..c...........tG.hhucspFYsAsGRYulLsTCNpWTAcuLcuAGLshss.h.Lstu.s.........	0	19	41	49
+9434	PF09602	PhaP_Bmeg		Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a protein found in polyhydroxyalkanoic acid (PHA) gene regions and incorporated into PHA inclusions in Bacillus cereus and Bacillus megaterium. The role of the protein may include amino acid storage.	22.20	22.20	22.60	22.50	22.00	20.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.21	0.71	-4.42	2	94	2009-01-15 18:05:59	2007-05-09 13:53:14	5	3	92	0	6	35	1	162.60	80	76.60	CHANGED	MpTh.Y-.llDAhWcpWopuLp.hususKQlEQhTLcsLcQQQ-h...lTpuV-pLptp.pQapAphps..pchVcpL...sGNulsDphpEWpp+h+Eh.s+hQpLhhs.oKoShSllpQsptQacpsspQhlEpQphpRpEhQ+..-ualEphK.hQhphApphEp	...........................METKPYE.LVDAFWKNWSQSLSLFSSAGKQLEQLTLET.LKQQQDALHKLTSGVDELEKELQQF.......TAQFNNQYTDYVKQL....TGNSLNDQIN..EWQ-KWKELSAHM..pQLTVSPTKTSLSILTQTSGQFEETTKQFIEQQQLQREEAQKQLEGFLEEFKoKQLELAKKFEE......................	1	0	2	3
+9435	PF09603	Fib_succ_major		Fibrobacter succinogenes major domain (Fib_succ_major)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This domain of about 175 to 200 amino acids is found, in from one to five copies, in over 50 proteins in Fibrobacter succinogenes S85, an obligate anaerobe of the rumen. Many members of this family have an apparent lipoprotein signal sequence. Conserved cysteine residues, suggestive of disulfide bond formation, are also consistent with an extracytoplasmic location for this domain. This domain can also be found in small numbers of proteins in Chlorobium tepidum and Bacteroides thetaiotaomicron.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.59	0.71	-3.79	40	375	2009-01-15 18:05:59	2007-05-09 14:02:06	5	24	93	0	169	369	212	179.60	19	39.68	CHANGED	VpIGsQhWMAcNLcsscYRNG-.sl.psts.ttW.....shssuAaCaYsscspssph.........YG+LYNWaAV.........sDs..................R.GLAPpGWHlPoD.sEW.ptLtshl.............G...GcstuGutLKu..h.....stWttss.sss........sspsGFsA........lP.uG.hRsssGsF.hhtGphuhaWooocss....stpAasRplshs....s.sslt+spss..+p...tGaSVRClK	..................................................................................................hstphWhspNLp...................................................ssshs..........pt..psttt.............................hG.hhYsatus....................ss................................................................p.slsPpGW.+lPop.sEa.ppL.hphh.................................................s............p..tsupt.lps...............staht.t.....t..........................tsthGFss...........................hs..sG...ht........t...........s..........s.....s............t.......h.......tt..sphshaWo.s..s.pts..........s.t.sh..h.h.h.ht......t..t...h..ps.ths........pt......uhulRCl+.....................................................................................	1	120	132	160
+9436	PF09604	Potass_KdpF		F subunit of K+-transporting ATPase (Potass_KdpF)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry describes a very small integral membrane peptide KdpF, a subunit of the K(+)-translocating Kdp complex. It is found upstream of the KdpA subunit (IPR004623). Because of its very small size and highly hydrophobic character, it is sometimes missed in genome annotation.	19.20	19.20	19.40	19.50	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.52	0.72	-6.83	0.72	-4.02	40	728	2009-01-15 18:05:59	2007-05-09 14:09:44	5	1	704	0	103	314	5	25.00	44	58.04	CHANGED	hhluslluluLhl...YLhhALlcPE+F	.........llulllshhLls...YLlYALlpsEcF..	0	34	62	84
+9437	PF09605	Trep_Strep		Hypothetical bacterial integral membrane protein (Trep_Strep)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of strongly hydrophobic proteins about 190 amino acids in length with a strongly basic motif near the C-terminus. It is found in rather few species, but in paralogous families of 12 members in the oral pathogenic spirochaete Treponema denticola and 2 in Streptococcus pneumoniae R6.	26.50	26.50	27.50	27.00	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.34	0.71	-4.62	23	1171	2009-09-11 16:54:32	2007-05-09 14:23:32	5	2	634	0	118	730	19	180.40	28	94.33	CHANGED	ps+DLlsIGlFuAlYFlh.hhlsshluhhsPhhh..hhtPslsulluGslaMLhls.+VtKhGslolhullhullhhhsGph.hhhhlssllsullA-llt.phu...pY+shptshluYslFuhhhs..G.shlPhahhh-sYh.tshhppGhupsYl-shhthhss.hhhhlhllssllsuhlGuhlGp+lLKKHFcK	................................hKDllshGlFsllY.Flh.hhls.s.h.l..u..h.l.....s.hhh..........hhhPshsulluGslahlhhs.KVt+hGsl.hlhGllhulh.h.h.hs.Gas..hsshlsull.s.ullA.-llt..p.hG...pYc.s...h.p.t.sh.luaslFu..h.shs..G.shl..hal.s.tctYh.tph.h.tp.uh.up-Ylstlh.th.h.ss...hhhhlhlh.sshlsullGuhlGptllKKaFpK....................................	0	64	86	105
+9438	PF09606	Med15	ARC105; ARC105_Med_act; 	ARC105 or Med15 subunit of Mediator complex non-fungal	Coggill P	anon	pdb_2gut	Domain	The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development [1].	26.20	26.20	26.40	26.40	25.90	25.60	hmmbuild  -o /dev/null HMM SEED	799	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.78	0.70	-13.71	0.70	-6.34	7	273	2009-09-11 06:41:54	2007-05-09 14:50:32	5	17	89	1	140	249	1	349.30	26	82.33	CHANGED	QpVVspIc-AhppsGhsp.....oKsut-MEsHVFtKA+o+DEYLuhVARLIlHhR-hppKppQsp.s.....................DPhNALQsLsutss.sst....shshGP.tP.GtphGG.Gshoshhpsh................psQ...u..shu.PpthstVuths.usQhss.h.........tt.pt...ttttuthtt.t.p.tQt...ttt.P.tMhtshhs.....t..tttt.....ttt.t.ts.pQ.p.h...t.Q.p......Q......p.phpQ.ps.tputsQh.p..tsput.psQphttu.sQ..shpQt.sttp.p.s.hthh.tQhpQh.........stG.ttshupst..Psp.hss.s..Qt...hs.............hhs.tt.t.h............Q.psptQtQpttsp..stt...........................................tQ.s...tstpuuph.u.t....................................................t.....ptsshsshsssthsptp..MMSussPs........pspssQtM..sPQPp.PpPstPsups..sp.ssus.hPSP.uhhPSPSPQ.uQsssstRs.tp......SPG.sL.......NTPGp..sus.SPhssp..EEp.Yh-Kh+pLoKYIEP..L+RMIsKh-ps.tch.cchuKMKpLL-ILosPopRsPLcTL.KCEhALp.........sphus.p.sP..........hspPLl-AV.uNlpSPlhNHoL.R...TFtPshpAlaGssIts.sssu+p.Rlp.D-........pQpIPplLQGElARL-sKFhVsLDPstpuss.tsl+LICpLDDKpLPsVPPlplolPt-YP.pSPphp.tpppYsAsPFL.p.Vp+shhu+lspLPthaSLotLLsTWt.uVRQAC......................hLuh	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hst.....................................................................................................................................................................................................................................	0	51	60	103
+9439	PF09607	BrkDBD		Brinker DNA-binding domain	Coggill P	anon	pdb_2glo	Domain	This DNA-binding domain is the first approx. 100 residues of the N-terminal end of Brinker. The structure of this domain in complex with DNA consists of four alpha-helices that contain a helix-turn-helix DNA recognition motif specific for GC-rich DNA. The Brinker nuclear repressor is a major element of the Drosophila Decapentaplegic morphogen signalling pathway [1].	23.40	23.40	23.40	23.50	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.81	0.72	-4.40	3	116	2012-10-04 14:01:12	2007-05-09 14:53:10	5	11	65	1	88	108	0	53.40	40	11.82	CHANGED	GSRRuaouuFKL..QVlESacsDNsC+Gs.RAsA+KYNIpRKpVcKWLQsEsQLQsucAp	....................RRoasssFKL..pVl.-hA.c..psssCp.....sA+cFsl..pc..+pVccWpchcspLpst...................	0	25	41	71
+9440	PF09608	Alph_Pro_TM		Putative transmembrane protein (Alph_Pro_TM)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family consists of predicted transmembrane proteins of about 270 amino acids. Members are found, so far, only among the Alphaproteobacteria and only once in each genome.	20.40	20.40	20.50	21.30	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.40	0.70	-4.84	49	249	2009-01-15 18:05:59	2007-05-09 15:58:14	5	2	244	0	90	221	746	229.60	36	87.83	CHANGED	EplVhuLSpccVsIossFsGu-lllFGAlcptssh.tt..shDllVslpGPspslslR+K-RhhGIWlNs-uhphcssPoFYAVAoo+Plcclssts.pttchplGls.........hs...................ttssss.sssss..pFpcALlRl+pppGLY........ppptsuVplhppsLFRsslpLPAsls.GsYpsclaLhRsGplluptpsslpVpKsGhEpalashA+ppshlYGLhulslAlhsGWhAuslFRth	...................Epl.lulSscpluITusFsGs-lhlFGAlcpts.sh........tt..thDllVslp.G.Ps.psl.s.VR+.K-RhhG.l.WlNssShpFtslPshYulAooRslpcls.s..tp.shp...phplGlpph..........Ls......................ss.ss.ss...sssh.pFtsuLh+l+pppGLY.........ppc.uuVph....hsp.....oLFR....AslsLPAslPsGpaps+shLhRsG.thlsptssslclhKsGlEphlashA+ppsllYGLhulhlAlhsGWhuuhlFR+....................	0	29	59	70
+9441	PF09609	Cas_GSU0054		CRISPR-associated protein, GSU0054 family (Cas_GSU0054)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a rare CRISPR-associated protein. So far, members are found in Geobacter sulfurreducens and in two unpublished genomes: Gemmata obscuriglobus and Actinomyces naeslundii. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associated proteins, have low levels of sequence identify, have sequence relationships that suggest lateral transfer, and show some sequence similarity to DNA-active proteins such as helicases and repair proteins.	20.80	20.80	21.90	21.80	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	519	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.62	0.70	-5.68	4	90	2009-01-15 18:05:59	2007-05-09 16:03:54	5	2	55	0	36	91	7	277.10	14	76.09	CHANGED	hhulohphhsG+acuss..........sD.usP...EWPPuPhRlFpAlVAoht.chs......E-h-sLpaLpu...Pslhthssshsu........psshphVstsasRG.pchasGsus.hpc......pslslPcsssVthlWc.s-ss-tplA.ls+lstplsahGRspShshspVV.sGul..........hs.cWlsct-s.....GslslRsPhsG.....pLp-Lps+aEshhshh.hGsh..s.PhssYs.hsphlu.-.s.ps..s..h.ch.shG.+tssssphtLDltshs..T-uLRRAslup........hcssplsuhlpGH....GD-tp......HsAYLslssluc+tAcG+l.slGshhPs.loth-......GhhGs-.s..huLh+s+pLtclcLc.ss....VuhhuLps....pths..tuS+oWsoVTPhhLsRaP............................s++lp..................ssullttSlspsGhP.Pttlpslss.tlsGshR....hcRYsshcshpphP....hHs+Isa......Pp.lcGPlhlGusRaaGhGLFsP	.........................................................h...............................t.....E..PtP.Rlhtuhhush....th.....................t.........hl....t......................h.....................................................................................................................................................................h.h......................h...hh..h.........s.h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	28	32	32
+9442	PF09610	Myco_arth_vir_N		Mycoplasma virulence signal region (Myco_arth_vir_N)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents the N-terminal region of a family of large, virulence-associated proteins in Mycoplasma arthritidis and smaller proteins in Mycoplasma capricolum. It includes a probable signal sequence or signal anchor, which, in most instances, has four consecutive Lys residues before the hydrophobic stretch.	20.40	20.40	20.50	24.10	19.40	19.30	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.55	0.72	-4.00	6	43	2009-01-15 18:05:59	2007-05-09 16:05:19	5	1	12	0	15	38	0	32.70	60	2.93	CHANGED	MYFLKKKKNKILshALVASLATSLSFGSVIYYS	.MaFlKKKKNKILshALlASLssSlSFGSVIYYS...	0	4	15	15
+9443	PF09611	Cas_Csy1		CRISPR-associated protein (Cas_Csy1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2465 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy1, for CRISPR/Cas Subtype Ypest protein 1.	20.20	20.20	20.50	20.30	19.60	20.10	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.31	0.70	-5.52	18	182	2009-01-15 18:05:59	2007-05-10 09:29:29	5	1	173	0	41	149	8	345.90	35	83.41	CHANGED	spYphpsWLsD.AA+RAGQIpLVTHshKasHsDA+GSslashs......tptsspaLuo..s.sphAhDslGNAAALDVhKhLplph.-.Gc.oLLspLppsDssALssLucsscQ....hcpWhsuFtslhssc..phoSHpLAKQlYFPl...........tsspYHLLuPLFuSoLAatlap+lppsRFu-psKtARpA++cpcaHspshhpYPsLAsQphGGTKPQNIStLNSpRGGcsaLLsShPPpWc.spp+sPhphcSlFp.psthpspspstlppLppaLtssp...........sNhclRppRs.phlsplIDpLlphsuplQph...sGWSspspp..pLtcspQLWLDPhRs..........sDpsFppERcpsD.W.pplupcFupWLNppLpp....ppl.lG-sEt+cWpp	..............................................cYphcsWLs.c.AA.p.....R.AtQlphsTHssKhtHsD...u...Ku..sslh.....h.s.......phspshlso...slsph.......s.hD.s.h.GN.AAA.....LD.lsKhLphph.-...Gp...oLlstlpp.s-.phhphhu....p...spp............hp.pahpuFtphhpsp...p.soHclsKQlYFPl...........tsspYHLLsPLasSSLspthap+lsp.sRFS-psKpuRps++pschp.pshhph.slAs.phGG.........TKPQNIShL.NS.pGG+saLLsShPPpap..st..+.P.p.cohF..p..sththtspshltphpphltsst................NshclRstRt.phlspllDhlhthsttlQph...sGWSpp.....pL.ttp..plWLDPhRs...............s-ttFpp.c.cpppD.W.pplspcFutWL....NttLpc.......pphshGssEhpcWp.t...........................................	1	10	25	33
+9444	PF09612	HtrL_YibB		Bacterial protein of unknown function (HtrL_YibB)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The protein from this rare, uncharacterized protein family is designated HtrL or YibB in E. coli, where its gene is found in a region of LPS core biosynthesis genes [1]. Homologues are found in Shigella flexneri, Campylobacter jejuni, and Caenorhabditis elegans only. The htrL gene may represent an insertion to the LPS core biosynthesis region, rather than an LPS biosynthetic protein.	23.60	23.60	23.80	24.80	22.20	23.50	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.82	0.70	-5.14	3	269	2009-01-15 18:05:59	2007-05-10 09:39:14	5	1	240	0	15	100	74	249.20	59	89.51	CHANGED	M-spTTIITAFFDIGR+Da.......KclsRSNDKYaSYFEFLAuLKNcMIIYTsEslKc+IcuIRscasLE-KTThIIlc-Ip-hccpIYKRII-IppDcoF+Na...lp.RphcNsEshSPcYsYLMhLKuaFVsDAIsRGLT-TN.lAWIDFGFNHGGNVFsshcpFDF.a...sshDENKINLFoIKK....sDQQslF-IhhuhEsaIMGGlIlusS+pWccFY+hsLEShKIhsShGIlDDDQlIhLaC..sYRRNs..sYNhIt+upWFDuLpHFpspslGuKLpI	................McsShTIlTAaFDIGRGDWsupcGF.ccLsRSsDsYFSYFE+LAuLENcMIIFTSPDLKsRVEAIRN.....GKPTT..VIVIDIK...Kp.....h.+a.I+....s.+.....Ic.K..IQ.KDESFTN+...L.-P+plK.NPEYWSPEYVLVsNLKsYFVsK.A.IphG.L...VK....Ts..LVAWIDFGYCR+s.N.V.TpGlKhWDFPF.......DEsKMHLF.TI....KKGLsloSpQplFDhM.IGNHVYIIGGAIVGSQHKWKEFYKLVLESQKITLNNNIVDDDQGIFVMC..YYKRsDLFN.LNY.LG.R.GKWFDLFRCFRSNTLGAKMQA..........................	0	8	9	15
+9445	PF09613	HrpB1_HrpK		Bacterial type III secretion protein (HrpB1_HrpK)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family of proteins is encoded by genes found within type III secretion operons in a limited range of species including Xanthomonas, Ralstonia and Burkholderia.	26.90	26.90	27.10	27.80	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.86	0.71	-4.74	8	155	2009-01-15 18:05:59	2007-05-10 09:40:55	5	1	96	0	27	103	0	158.00	31	94.89	CHANGED	shhpCssplluGLl-llssALpts......chtDhptlLpALRlLRPchsth-hhDGWLplsRtpWs-AtRlLR-l...-ssssshshu+ALhAhCLpuhpDssW+ttApclLtpssss-ulsLV+sLhuppshhpA.t....................ssssuu-Asussspu............s..tp.pahRl	..............h.pCstthlsGLl-shssALpts......c.tDhptlLsALRVLcPphssh-hh-uhLplt+tpas-AhRlL+c.l...ssss...sptshu+ALhAhCL.....pshsDssW+th........AsplLtsss..sssuhsLV+uL.stpshh.h......................................s.htsp..hts..s.............................................................	0	5	11	16
+9446	PF09614	Cas_Csy2		CRISPR-associated protein (Cas_Csy2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2464 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy2, for CRISPR/Cas Subtype Ypest protein 2.	25.00	25.00	32.40	29.70	19.10	21.30	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.62	0.70	-5.21	25	219	2009-01-15 18:05:59	2007-05-10 09:58:56	5	2	202	0	47	169	10	266.80	33	80.18	CHANGED	LlLP+l+VpNANAlSSPLTaGFPulTAFhGas.HALpRKLsspt...slplpusuVlsHcaplpshps...hs......psFsLTRNPL......sK...sGso........uuhlEEGRhHLslSLllpssuppt............sppptpthhppltpll.tshRlAGGoll.......phtpschhphs........tpchcphh++LlPGFsLlsRp-LLssthppLpps....................stsphlDAaL-hus.lpapshsspssp............Wp...+.....p.sGWlVPlslGYpul.SPh..atsGplpssRDspsPapFsEolaulGEWlsPHRl.p...........slsplLWpacsc..ppsl.....YhCp	...........lll.cl+lpsANAlSu.lThGFPuhTsahGhs.HALpR+Ltp...pt.....sl..plpGsulhsHphplpsapss..hs..........hsFthTRN...PL......pK........pups............suh.EEu+hHLslSLllEhpsp.t.............ptttpthhpplpphh..ptRlAGGolh............shtpsplhph..............phcclhh.pLhPGasLh-RpphLscthpphppt............................sp.p.LDAhL-hss.lchps..stsss..................Wth..h.......tGaLVPlssGYpuI.SPl..htsGpsppsRss....phP...apFsEslaulGcWhh.a+l.p...................................slpphhWpYchp...pp.h.....Yhh............................................	0	9	25	35
+9447	PF09615	Cas_Csy3		CRISPR-associated protein (Cas_Csy3)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This entry, typified by YPO2463 of Yersinia pestis, is a CRISPR-associated (Cas) entry strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy3, for CRISPR/Cas Subtype Ypest protein 3.	25.00	25.00	29.50	29.50	22.50	24.90	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.91	0.70	-5.34	23	219	2009-09-11 10:34:39	2007-05-10 10:02:20	5	1	207	0	48	165	10	318.40	48	97.09	CHANGED	csASVLAFERKLssSDAlhauusW-s+s...pasPlplpEKuVRGT...ISNRLK.stspDPAKL-A-l..ppsNLQpVDVAsLPs-sDTL........KlpFTLRVLushupPSsCNsstYpppLtpslssYhpcpGFsELAcRYApNLANGRFLWRNRlGAEslplpVs....spstpsas.FDAhpasLRsF...spsspplspLuphItpGLuu.ssaslLcVsAalclGtGQ.EVaPSQELlLDc...s..cupKSKhLYpV....s..........slAAhHSQKIGNALRTIDTWYPcss-....hGPIAVEPYGuVTspGpAYRQPK.pKtDFYTLL...DsWlh+schP......slE.pQHYVMAlLIRGGVF.GE	..........sASVLAFERKLssSDAhhaussW.ps.pp...phpPlplpEKuVRGT...................ISNRLKs..shss....DPsKL.DAEl.....pKuNLQpVDsAsLs..-sDTL.........cspFTL+VLushupPusC........ND..pYptpLtsslpsYlpppGFpELApRYApNlANGRFLWRNRlGAEpIpVpVs...........tspppsap..F.supphuL+pF....spsspplppLAphIppGLuu.psas.......hLpVpAhl+lGtGQ..EVaPSQELVLDp.......pupKSKlLYpl.....s......................shAuhHSQKIGNAlRTIDTWYP-ssp....hsPIAVEPYGuVTshGpAaRpPK.pKhDFYTLh........DsWlh+sphP......sl.E.pQHYVMAsLIRGGVFG............	0	10	25	36
+9449	PF09617	Cas_GSU0053		CRISPR-associated protein GSU0053 (Cas_GSU0053)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is found in CRISPR-associated (cas) proteins in the genomes of Geobacter sulfurreducens PCA and Desulfotalea psychrophila LSv54 (both Desulfobacterales from the Deltaproteobacteria), Gemmata obscuriglobus (a Planctomycete), and Actinomyces naeslundii MG1 (Actinobacteria).	25.00	25.00	29.60	25.20	19.70	18.30	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.29	0.71	-4.47	4	71	2009-01-15 18:05:59	2007-05-10 10:12:02	5	2	66	0	28	72	5	173.40	26	46.68	CHANGED	uulllcAsLpPVpGts.+lhPsTF.....uussYph..thsDG...ssslllDSVsS.ANRlE..Lhshc.st..lV......P.Ipspls..stploslEhsHRhsDAhl..RsS.lstsp..spsltptLpssps+ss......csLhthtPpoLlaGsWDS...cpsptsKluR.luuhI.uYsVcsl....ppuu	....................................pLp.PssG...tltPssa...ssh......ss.usYsh......ph.....s.cG...............hpslLlDSspStANRhEthlhp.t..h..csup.....hl..........................thPhlpV..ph.p................sst..p.h..o.s.....lptsHRhsDual...Rsup.h...st.t...........h......pcpsh.hp.shp.s.s.s.psh.................psl.hchsPsuLlaGs.WcS....tpt..s...sph+lsRslsupI.u..........s............................	0	17	24	25
+9450	PF09618	Cas_Csy4		CRISPR-associated protein (Cas_Csy4)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a widespread family of prokaryotic direct repeats with spacers of unique sequence between consecutive repeats. This protein family, typified by YPO2462 of Yersinia pestis, is a CRISPR-associated (Cas) family strictly associated with the Ypest subtype of CRISPR/Cas locus. It is designated Csy4, for CRISPR/Cas Subtype Ypest protein 4.	25.00	25.00	25.10	25.10	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.26	0.71	-4.47	32	230	2009-01-15 18:05:59	2007-05-10 10:15:38	5	2	218	7	52	183	6	181.10	33	97.59	CHANGED	Yl-IplLPDsEhstshLhstlaspLHtsLsp....hspscIGlSFPpast............sLGspLRlau.sppsLppLptpsWlpshpD..YsplusltsV.Psssp.apshpRhpspu......shpRhh+Rhh+Rt....thstEpsptthspphp.pph..shPalplcStS.......ssQ.pFhLFIc..tphtspsssGtFsuYGLSss.......uTVPaF	......................Yl-IpllP...c.s...EhstthLhutlaspLHpsLst.............ptpscI..G.VSFPphst..............sLGs.pLRlau.sppsLppLptp.sWh..p.s.Lp.D..Ysplo.pltsV..Pp.p.sp..apshpRsQsKu......stpRhh+Rthp+t..................tlsp-psttch.pptp.ppt...............shPalpLcStS........opQ.pFhLaIc..tphts..p.s..spGpFsuYGLSps.......uTVPaF...........	0	12	28	39
+9451	PF09619	YscW		Type III secretion system lipoprotein chaperone (YscW)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is encoded within type III secretion operons. The protein has been characterised as a chaperone for the outer membrane pore component YscC. YscW is a lipoprotein which is itself localized to the outer membrane and, it is believed, facilitates the oligomerisation and localisation of YscC.	21.50	21.50	21.50	21.60	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.23	0.72	-4.33	11	875	2009-01-15 18:05:59	2007-05-10 10:43:35	5	7	808	3	107	364	9	110.00	50	60.76	CHANGED	s.tst.u.spVsGsVplpp..uLPhsAslpVTl....Lusssu+lLs.tssRhEssthPhpFsL.hNPspl.scucIhLpAtlphss+hsl.sss.QpVhs..ssschclpLlP	.....................shppssVSGTVhlRp+.lALPP.DA..VLTVTLSD..sSLA.D.AP.S..+..V..LA.Q+...u.l.R.T.E.GK...Qu.P.FsFsLPFNPu-lp...PNARll.LSAAIo.VssKLlFITD.T.lps.VIs..pG.G.sc.uDLpLVP.............................	0	15	35	72
+9452	PF09620	Cas_csx3		CRISPR-associated protein (Cas_csx3)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is encoded in CRISPR-associated (cas) gene clusters, near CRISPR repeats, in the genomes of several different thermophiles: Archaeoglobus fulgidus (archaeal), Aquifex aeolicus (Aquificae), Dictyoglomus thermophilum (Dictyoglomi), and a thermophilic Synechococcus (Cyanobacteria). It is not yet assigned to a specific CRISPR/cas subtype (hence the x designation csx3).	20.90	20.90	21.90	21.20	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.55	0.72	-4.18	7	37	2009-01-15 18:05:59	2007-05-10 11:28:15	5	3	34	0	14	37	1	78.50	31	36.24	CHANGED	chcLpcs...ltP-DLtplplPshlcsptG...VVlSGRuPIWLYuaLlHchH...TsalAsaDPRL..GAVVVuSHo.phR.GpVI.h	....................................ts...lp.ptltthp..lPt.ls.ptG....lV..loG+uPIWLYshLlHth.H...ssalAsa.DP+l..Gu.VVltoH.s.th.psGpll......	0	8	12	13
+9453	PF09621	LcrR		Type III secretion system regulator (LcrR)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family of proteins are encoded within type III secretion operons and have been characterised in Yersinia as a regulator of the Low-Calcium Response (LCR).	21.20	21.20	24.20	23.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.69	0.71	-4.90	7	286	2009-01-15 18:05:59	2007-05-10 11:50:46	5	1	274	0	15	74	0	113.30	36	83.16	CHANGED	hp-PLlPWhht+GltVpPahhpposI.LGath.hcGhcLAWRV-..ptRlWIVhl+RsptptGLuNPFAALYLLApAshslLGssahLYGNVsVLtuSsLsupRLA+FYpRWsGAS.E.psGWF.Ltst+Vhoh+sh+KRQp	.........p.l.paLcp+GhhspstaLstoAIhlG.ph.hssaplsYRl-..tpElIICpFcRhpsp....t..G.LtsPh.sL.h.hLhpthh.hhs......hl.u.......htss....t.pc..h..ah.ph.s....-..........Wa.h................sp.............................................................................	0	3	6	9
+9454	PF09622	DUF2391	CHP02587; 	Putative integral membrane protein (DUF2391)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry is found in Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus in a conserved two-gene neighbourhood. Proteins containing this entry appear to span the membrane seven times.	20.60	20.60	20.60	20.70	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.72	0.70	-5.24	9	115	2009-09-10 18:53:12	2007-05-10 12:00:33	5	1	112	0	52	100	14	184.30	24	90.50	CHANGED	sslsRGhAGAhLFulPhLhTMEhW.lGhalcPhRLhLlLslshslLhlLs+ttGFR+op...shc-sltDul.AhulGhlsuuhlLhlhthlssshuhcEhlGKlslpuVPsoIGshLuRs.Lttcus-sppt..t..............pstsuhhu-LhhhhlGAlFluhNlAPT-ElhlluhthoPaahlhllLASLhI.ashVatspFpsp+phtpppGhapt.lp.TlsuYllulhluhhhLWhFpRhs.ssuhpphlptslVLGhPAoIGuAAuRLll	........................t.....shsGuhh.hulPh.ho.EsWtlG..h.....p..Lh...hl..h.lsh.hlhh....hsh.tsFppph.........ph......h..l..hchhhAhhlu......hl...ssshlLhhhshls.h..s.......lt+lhl.shPhohGAhls.................................................p....hhGuhhhshsh..st-h..lu..h.....hhhh.h.hhh.h.hh.....................................h....h.s.......h......................................................................................................................	0	12	29	45
+9455	PF09623	Cas_NE0113		CRISPR-associated protein NE0113 (Cas_NE0113)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this minor CRISPR-associated (Cas) protein family are encoded in cas gene clusters in Vibrio vulnificus YJ016, Nitrosomonas europaea ATCC 19718, Mannheimia succiniciproducens MBEL55E, and Verrucomicrobium spinosum.	21.20	21.20	21.80	21.60	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.50	0.70	-4.89	17	107	2012-10-11 20:44:46	2007-05-10 12:53:01	5	5	94	0	44	103	11	188.90	25	58.63	CHANGED	hKplLlushGhoPQVlTETL.uLhppup......hss-lhll..oTpps+sphthsLL.............pphhp-a.......thpastsslpl..l.sspst.lsDIpotp-stthhshIhphltpLpps.s.tplHlSlAGGRKsMuhhhuhAhpLauc.pDpL.HlhVss.hE......pFhh.stpsthlplpstps.....st..h.VpLsplPalphpp.lsstlhp..uths.spsltphppt.s.	.........................................pplLlushGhoPQ....llTETlhsLhppst........hssElhll..oTps.stsph..thpLl...................tphhp-h.......thphppp...lpl.....hhs.ppst.lsDIcot....cDspthtchIhphltphptp.t..tlahsluGGRKsMuhhhshAhphht..tDtl.Hlh......st................................................h..hs..................................tt.............................................................	0	21	34	42
+9456	PF09624	DUF2393	CHP02588; 	Protein of unknown function (DUF2393)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	The function of this protein is unknown. It is always found as part of a two-gene operon with IPR013416, a protein that appears to span the membrane seven times. It has so far been found in the bacteria Nostoc sp. PCC 7120, Agrobacterium tumefaciens, Rhizobium meliloti, and Gloeobacter violaceus.	24.60	24.60	25.00	26.40	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.80	0.71	-4.68	40	338	2009-01-15 18:05:59	2007-05-10 12:55:27	5	1	213	0	42	168	8	149.40	34	87.04	CHANGED	hhhhhhhhlslhhcpp.....hhhhhlhhshlhhhh.hshh.........hhhhl.cpts+psplslspscp.lp..hspshhls..hslpNpuphsh................ppCplpscl.hp......sssshhpphthp.ts...ahpp...................ph.ltp..Lphscspph....phh...hs...t.sh...tshslph.pupCh	.............................................................h.LhshllhLplh.+ch.....Ahl.hhhhsIlhshL.lYhh...........hhpll.pppspsphoplsps+...lp....spulIls..hplpNhoKhsh................+cChlhhcIhspp....sssslhp-hph+.h.....appp....................ohEIh-..L.sNssp.h....Rhu...hs.....sh...NNhphhh.s.cCh.............................	0	11	34	41
+9457	PF09625	VP9		VP9 protein	Coggill P	anon	pdb_2gj2	Domain	VP9 is a protein containing a ferredoxin fold. Two dimers come together to form one asymmetric unit which possesses a DNA recognition fold and specific metal binding sites possibly for zinc. It is postulated that being a non-structural protein VP9 is involved in the transcriptional regulation of the White spot syndrome virus, WSSV, from which it comes. WSSV is the major viral pathogen in shrimp aquaculture [1]. VP9 is found N-terminal to the Pfam:PF07056 domain.	20.50	20.50	20.60	22.90	20.20	17.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.51	0.72	-4.17	6	19	2009-01-15 18:05:59	2007-05-10 13:38:38	5	2	2	7	0	15	0	77.60	41	19.98	CHANGED	Lpl+suFhlsG-c.s-+YEcVhh.oFcuV-.....olRKSELcDssaIVpLK-scpl+lpsGlccLRpLTGDsoLpIp.hlosshP	..LphcuuFhhhG-c.sc+YEcVht.oF-uV-.....olR+SELc-ssaIVpLKcscphphpsGlccLRpLTGDsoLpIp.hlossh........................	0	0	0	0
+9458	PF09626	DHC		Dihaem cytochrome c	Coggill P	anon	pdb_2fwt	Family	Dihaem cytochrome c (DHC) is a soluble c-type cytochrome that folds into two distinct domains, each binding a single haem group and connected by a small linker region. Despite little sequence similarity, the N-terminal domain (residues 12-75) is a class I type cytochrome c, that binds one of the haems, but the domain surrounding the other haem is structurally unique. DHC binds electrostatically to an oxygen-binding protein, sphaeroides haem protein (SHP), as a component of a conserved electron transfer pathway.  DHC acts as the physiological electron donor for SHP during phototrophic growth [1]. In certain species DHC is found upstream of Pfam:PF01292.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.98	0.71	-3.44	35	196	2009-01-15 18:05:59	2007-05-10 14:12:42	5	5	163	2	75	205	20	107.70	32	55.86	CHANGED	YhccCuuCHhAaPPtlLPupSWpplhssLspHFGssAs.LsssspttltsYLpspuuststs.............ssssPh.RITcs.aFpcpH..pcls.thhp.pspltohusCsuCHss.AcpGsF	....YtppCu.uCHhAaPPslLPupoWptlh..s..s..LppHaGssAs...Ls.sssptpItsYLtspAuptst.......................sssss.+Iocs.aFhcpH....scls.......thhp...spltohusCsuCHstAppG.a.......................	0	19	56	66
+9459	PF09627	PrgU		PrgU-like protein	Coggill P	anon	pdb_2gmq	Domain	This hypothetical protein of 125 residues is expressed in bacteria but is thought to be plasmid in origin. It forms a six beta-strand barrel with three accompanying alpha helices and is probably a homo-dimer in the cell. It may be involved in pheromone-inducible conjugation [1].	25.00	25.00	77.10	77.10	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.52	0.71	-4.53	2	54	2009-01-15 18:05:59	2007-05-10 14:19:04	5	1	40	2	2	31	0	100.60	89	88.98	CHANGED	MKElAIQEK-lshpWpG.pG+Llhl+lKps+shEhhhNpQlT.ENIpEIsslpllKNGKoLsLcV.sE+Shash.p.uphpVPhFaIcT.IpRtsac-hF..............Gpp..lKt	MKEIAIQEKDLTLQWRGNTGKLVKVRLKNTRAMEMWYNKQITEENIQEITTLNIIKNGKSLALEVYPEKSIYVKPNLGRINVPVFFIKTPINRGlFEEIF......................GETLK.......	0	2	2	2
+9460	PF09628	YvfG	Yvfg; 	YvfG protein	Coggill P	anon	pdb_2gsv	Domain	Yvfg is a hypothetical protein of 71 residues expressed in some bacteria. The monomer consists of two parallel alpha helices, and the protein crystallises as a homo-dimer.	25.00	25.00	123.50	123.30	22.40	18.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.22	0.72	-3.83	2	24	2009-01-15 18:05:59	2007-05-10 14:21:45	5	1	24	4	6	13	1	67.00	88	93.33	CHANGED	pLFos.hhhpNh+pahp.Npu..sKIpAhNuYY+sVsuolltDplsKNAsllhRhpHL-EAYpKVtpt	ELFSVPYFIENhKQHIEMN.s.EDKIHAMNSYYRSVVSTLVQDQLTKNAVVLKRIQHLDEAYNKVKRG	0	2	3	4
+9461	PF09629	YorP		YorP protein	Coggill P	anon	pdb_2heq	Domain	YorP is a 71 residue protein found in bacteria. As it is also found in a bacteriophage it might be of viral origin. The structure is of an alpha helix between two of five beta strands. The function is unknown.	25.00	25.00	66.00	65.80	19.10	16.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.32	0.72	-4.00	2	8	2009-01-15 18:05:59	2007-05-10 14:43:34	5	1	8	1	1	7	0	65.40	75	99.43	CHANGED	MPKYWSYPVGLAVEINNNARYGCPHHVGRKGKIIEHLHSATYDYAVSDETGDITYFKEHELTPLKGGLAYV	MPKaWSYP.GLcV.INpNA+.uCPHHVGRcGKIIEhLHSATYDYAVSDETGDITaFKEHELNPhKGG..........	0	1	1	1
+9462	PF09630	DUF2024		Domain of unknown function (DUF2024)	Coggill P	anon	pdb_2hfq	Domain	This protein of 86 residues is expressed in bacteria.  It consists of four alpha helices and two beta strands. Its function is unknown. One UniProt entry gives the gene name as Traf5.	20.40	20.40	21.10	69.20	20.10	17.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.85	0.72	-4.27	13	50	2009-01-15 18:05:59	2007-05-10 14:46:45	5	1	46	1	22	46	40	81.50	45	95.21	CHANGED	MclHVaDTaVps+DG+hMHFDVll..sscstc+shpYAKpaLcolG.csssloppECpFCHSEtAss-VppuIcppGaaIhcM	....Mcl+VFDTaV+s+DG+hhHFDVll...sccpst+AhpaA+cWLsuhG.csAsloppcCpFCHSE...tAss-VtcuI+p+GaaIhph.	1	9	15	21
+9463	PF09631	Sen15		Sen15 protein	Coggill P	anon	pdb_2gw6	Domain	The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this hetero-tetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold.  Each monomer consists of three alpha-helices and a mixed antiparallel/parallel beta-sheet. Two monomers of Sen15 fold with two monomers of Sen34, one of the two catalytic subunits, to form an alpha2-beta2 tetramer as part of the functional endonuclease assembly.	22.00	22.00	22.20	22.10	21.80	21.60	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.41	0.72	-3.78	44	217	2012-10-11 20:44:46	2007-05-10 14:48:09	5	8	184	2	146	215	1	113.10	26	62.71	CHANGED	hVhtsLhchptWp-Vcl..hppp...t.......................lhllpGpPspphstp.................................EhllPlph....sptlolcplcplFspl.....s..t......................sp+llLAIlssDuTlVYYh...lpcGlhc.....Pcp.s	.....................................................................................VhhsL.ct+.Wpplph.ht..p.hp.....................hhhlpGh..ct.hh............................................phVlPssh.........spphohpplpplac..tltt.t.t.............................................spplhLAhlp....s....DuTlVYYh..lpcGhhpPc..............................	0	37	71	113
+9464	PF09632	Rac1		Rac1-binding domain	Coggill P	anon	pdb_2h7o	Domain	The Rac1-binding domain is the C-terminal portion of YpkA from Yersinia. It is an all-helical molecule consisting of two distinct subdomains connected by a linker. the N-terminal end, residues 434-615, consists of six helices organised into two three-helix bundles packed against each other. This region is involved with binding to GTPases. The C-terminal end, residues 705-732. is a novel and elongated fold consisting of four helices clustered into two pairs, and this fold carries the helix implicated in actin activation. Rac1-binding domain mimics host guanidine nucleotide dissociation inhibitors (GDIs) of the Rho GTPases, thereby inhibiting nucleotide exchange in Rac1 and causing cytoskeletal disruption in the host [1]. It is usually found downstream of Pfam:PF00069.	25.00	25.00	43.00	42.30	23.90	19.00	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.76	0.70	-5.34	2	33	2009-01-15 18:05:59	2007-05-10 15:45:29	5	2	30	3	3	15	0	287.60	85	40.67	CHANGED	DsRRlTP+KlRELSDhLRhHLSSAuT+QLshGhsLSDLssM.ssLDKAERpthsDpsQlKSFNSLILKsYuVIuuYlKGc.s-oKospsEsSP.hpuNhMhSlsEPoLppIQtpLsQoHu.sDIuoL.Ru+pHLETLLpVLhs.S.Q.p.VosEsYsFL.RlAEsKsoLu.pLssLptQQpps+upLShLhptssuWAssARQuL.RFDShRPVVKFGo.Q.hAlHRpMhAAaAAhTLQEVutFss-MRpFsAsuhPLLhQLGRSoLhDEtLs.QREpLRELsTlAERLNRLppEWh	.......DVRRITPKKLRELSDLLRTHLSSAATK..QLDMGGVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYRVIE.DYVKGREGDTKNSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSDIGSLVRAHKHLETLLEVLVTLSQQGQPVSSETYGFLNRLTEAKITLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTVDSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAERLNRLEREWM.	0	0	1	1
+9465	PF09633	DUF2023		Protein of unknown function (DUF2023)	Coggill P	anon	pdb_2guk	Domain	This protein of approx.120 residues consists of three beta strands and five alpha helices, thought to fold into a homo-dimer. It is expressed in bacteria.	21.30	21.30	54.60	54.40	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.26	0.72	-4.07	10	133	2009-01-15 18:05:59	2007-05-10 16:32:13	5	1	133	2	35	108	1	100.10	53	83.50	CHANGED	+lFhHHIYEapKGlRsLlLhTLsscttstshtRLcppuIsYalQcs.ups+lNlFFGsspClcslRplss.+PLspLTsEEDFlLGuMLGYDhppQCcRYLpR	..+lFhpHIYEacKGVRphVLaThs+capshAlpRLcppsIsYhIQ.V..uss+lNLFFG+pECl-slRtllp.+PLNpLTPEEDFILGuMLGYDlptQCcRYCpR..	0	12	24	29
+9466	PF09634	DUF2025		Protein of unknown function (DUF2025)	Coggill P	anon	pdb_2hg6	Domain	This protein is produced from gene PA1123 in Pseudomonas. It contains three alpha helices and six beta strands and is thought to be monomeric.  It appears to be present in the biofilm layer and may be a lipoprotein.	25.00	25.00	170.10	169.90	24.20	17.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.24	0.72	-4.29	5	33	2009-01-15 18:05:59	2007-05-10 16:37:21	5	1	33	1	11	25	1	106.00	75	96.84	CHANGED	MSITSppICQAADQLKGFVGFNRKTGpYIVRFSEDSFGMDVADDoIlPsSEFVWAsssDssMsLcREpLQLLLEQNIDDRlNIoEPLRVYLRRoDLPEIpApRSLl	MuITSsDICQAADtLKGFVGFNRKTGpYIVRFSEDSFGMDVADDSITPTSEFVWuuspD.ssMpLsREpLQlLLEQNIs-RLNIGEPLhVYLRRpDLPEIsAQRpL...	0	1	2	7
+9467	PF09635	MetRS-N		MetRS-N binding domain	Coggill P	anon	pdb_2hsn	Domain	The MetRS-N domain binds an Arc1-P domain in a tetrameric complex resembling a classical GST homo-dimer. Domain-swapping between symmetrically related MetRS-N and Arc1p-N domains generates a 2:2 tetramer held together by van der Waals forces. This domain is necessary for formation of the aminoacyl-tRNA synthetase complex necessary for tRNA nuclear export and shuttling as part of the translational apparatus. The domain is associated with Pfam:PF09334.	21.20	21.20	21.90	42.10	20.60	21.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.58	0.71	-3.73	5	42	2009-01-15 18:05:59	2007-05-10 17:08:36	5	2	39	1	27	42	3	115.50	37	15.90	CHANGED	KGHoutLQLANNLKLALALtLAsssLKLclNEDcutPpLhsouoGFcLFDANAILRYVLcDFEupcS-cYpaAluSLEshLYH..K-ssc-HlsclsNKuL-NYL.lsh-EPLoATcLIlFANsY	.......Ktpsh.LpLANNLKlulAlphhs.tsL..clpls.-Ds..us...hpLhsspss.FpLh-sNAIlRYlhsDFps.ppu.cap.....hpshLYp....Kp..ppclp.hss.tltpah....cp.losoplIlFAslY.....................................................	0	3	14	26
+9468	PF09636	XkdW		XkdW protein	Coggill P	anon	pdb_2hg7	Domain	This protein of approx. 100 residues contains two alpha helices and two beta strands and is probably monomeric. It is expressed in bacteria but is probably viral in origin. Its function is unknown.	23.00	23.00	23.50	23.30	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.55	0.72	-4.18	4	40	2009-01-15 18:05:59	2007-05-10 17:10:23	5	1	35	1	9	35	41	96.80	32	88.42	CHANGED	M.Lh-AIhYpYPsAsspKDF.lRNDGDG..SYIpcWplcAPhPTEtELcsWWEEhQpNPsY-PP.Ql-hLAQELupEKLhRKQLEc.sppLGsELSslKLplLsLKG-	..........................................................lh-slhahaPssss.hDa.lpssup.G...hItcWplp.hP.PTptpLcphac-htcs..sshpsPspl-hLuQ-LupEKLtRKph-ph.psLGppLuslKLplLplKGt........................................	0	4	6	7
+9469	PF09637	Med18		Med18 protein	Coggill P	anon	pdb_2hzm	Domain	Med18 is one subunit of Mediator, a head-module multiprotein complex, that stimulates basal RNA polymerase II (Pol II) transcription. Med18 consists of an eight-stranded beta-barrel with a central pore and three flanking helices. It complexes with Med8 and Med20 proteins by forming a heterodimer of two-fold symmetry with Med20 and binding the C-terminal alpha-helix region of Med8 across the top of its barrel. This complex creates a multipartite TBP-binding site that can be modulated by transcriptional activators [1].	20.70	20.70	21.10	20.80	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.51	0.70	-4.84	26	307	2009-01-15 18:05:59	2007-05-10 17:12:11	5	6	206	12	211	292	0	171.20	21	91.12	CHANGED	pELhLhuSlsspshpphlppLpuLsu..p..Ppphtchphla+...s..........p.t...lpspstthpphhh+htpphspt.................hh....................p.s...tp...........................................ppsWpLphtDhP-sGp.spsssspphhsssl..............................................................................................pssslhpalpchG.achshEYhhcGhhFhp.uslhItlh+lhp.hsspspt...................p.hshSssallcs.lslscus-h.-thspuhtcL.tlp-pL+shlpLEhsDR..hDoR	...............................................................................................ph.L.u..l.t.t.th..hhp.Ltshss.....s..h.phphhh................................................................................................................................................................................................t..aplph.s.......Pt.s....p..tp....s.......p..hhp..................................................................................................................................................ptsh.thhtthG.ath..pahhtGhhahh.s.hhl.l.+hh..h....tt.................................p.thhlph....h.h.tstp.....t.t......htp.Lpshh.h............................................................................	0	63	97	163
+9470	PF09638	Ph1570		Ph1570 protein	Coggill P	anon	pdb_2hq4	Domain	This is a hypothetical protein from Pyroccous horikoshii of unknown function.\	   It contains six alpha helices and eight beta strands and is thought to be monomeric.	20.70	20.70	21.30	24.10	18.10	20.10	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.74	0.71	-4.42	4	13	2009-01-15 18:05:59	2007-05-10 17:14:26	5	1	13	2	11	17	0	152.10	56	97.29	CHANGED	MhCEEKLEVFENGF+D-KFNlElcaYGpDuRKVLLAlIYELYLP-YGpEYVYPFECAKEFWsIYhDusElcsEEscLKPlKFlSESVhpKlcc.LccIcsPlEVK....lEcAclYKsK-GYLslGKNFlLD.+GRLFIFNKPSluEhILKYIWcW	................................MhCEEKLEVFENGFcDGKFNlclEaYGpDARKlLLAlIaEL.YLPDYGp-YVYPFECAKEFWGIYhDuuEIpsEEh+LuPlKFlscSVhsKLEcsLc-IcAPtEVKt.lslE+A-laKlKcGhLslGKNFlLDt.+GhLFlFNKPSstElILKYlGh............	0	1	1	6
+9471	PF09639	YjcQ		YjcQ protein	Coggill P	anon	pdb_2hgc	Domain	YjcQ is a protein of approx. 100 residues containing four alpha helices and three beta strands. It is expressed in bacteria and also in viruses. It appears to be under the regulation of SigD RNA polymerase which is responsible for the expression of many genes encoding cell-surface proteins related to flagellar assembly, motility, chemotaxis and autolysis in the late exponential growth phase. The exact function of YjcQ is unknown [1]. However, it is thought to be a prophage head protein in viruses [2].	21.80	21.80	22.20	22.10	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.14	0.72	-3.90	8	83	2009-09-10 15:07:02	2007-05-10 17:17:20	5	1	76	1	15	64	1	92.60	25	87.98	CHANGED	tYKILptlhauaEshpc.D.slhD........cphscsLphLpD-GYIKGlphp.s....slhsuhssshlTh...cGlsYL-ENohhKKAYKshKEl+-WlP	.........Y+lLphlht.s..h..cphpth.c...s.hhp.......lspphhsphlphLh--GhIcGlphhpth.......phhh.t.h.pshpITh...cGlcYLp-NShhpKshchhK-hpt.............	0	9	12	14
+9472	PF09640	DUF2027		Domain of unknown function (DUF2027)	Coggill P	anon	pdb_2huh	Domain	This protein domain is of unknown function. though putatively involved in DNA mismatch repair. It is associated with Pfam:PF01713.	25.00	25.00	45.80	45.00	23.00	22.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.95	0.71	-4.88	5	110	2009-01-15 18:05:59	2007-05-11 10:06:21	5	2	110	1	14	104	3	160.50	48	43.58	CHANGED	LNVaLAYVPpDhKAluTTPFETYLVNDSNYYLYYTYLSAEGsuW+sRSHGlIEPNTKLaLEEFsKu-LNDhERVsVQLIAFKDsKsFslKPAVSVELRIDTVKFYKLHTFpEoDFFEEPALIYDIV+NDhPVKQVaVSAEELKEALlQKKssD+s.pPQsllK	..LNVaLAaVPpD.hKshsoTsFEsYLVNDSNYYlaaoYh..ou.EGp.u.WpsRupGhlEPNTKlhlEEFs+ssLN.-hE+lsVQllAaKcsKsahlKPAlsVElRIDsVKFYKLHTFp-sDFFEpPALlYsIV+sDhPs....+plh..VsAc-lppuhhpKp..t.-.t....h...........................................	0	5	12	14
+9473	PF09641	DUF2026		Protein of unknown function (DUF2026)	Coggill P	anon	pdb_2hly	Domain	This protein of approx. 100 residues is found in bacteria. It contains up to five alpha helices and up to seven beta strands and is probably monomeric. Its function is unknown. It is cited as a major prophage head protein [1], so might generally be of viral origin.	25.00	25.00	156.50	156.40	22.30	18.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.31	0.71	-4.95	4	14	2009-01-15 18:05:59	2007-05-11 10:08:21	5	1	14	1	5	16	1	201.70	47	95.83	CHANGED	sLoDY.RIYpVl+uVLhS.tsAcss+AChFFuhhGAaILpcHY+lcA+shuGhhuathu..hsslLhFu.pIEcsplpSu--sFHsWVpsDsallDFMAPhFsEshtut.hshslPtKMhQR+L-sMAsS.ssL+puGDFhahPs.-lTpcLtt+htppth.tDllslsssWatKpPpphssoluhsDt+GpssplsLsssp.lhGAW	.p.oDYpRIYRVIpSlLlu.pNADsAsAshaFSTFGAaILppHYKlcAhPpuGhAAYsLG...uslLhFu.+c-DGh.VsuAs-sFHCWVEADGWAIDFMAPtFupuscu....LslPsKMFQRsLuuMAsSlsDLspSGDFFYcS.-s-sTschhsDacppshluDlusVAssWFRKoPKpMssSlols-pcGcsp.plPLoGps.lsGuW	0	1	2	4
+9474	PF09642	YonK		YonK protein	Coggill P	anon	pdb_2h4o	Domain	YonK protein is expressed by the bacterial prophage SPbetaC [1]. It is a 63 residue protein that associates into a homo-octamer in the form of a beta-stranded barrel with four outer helical features at points of the compass.  Its function is unknown.	25.00	25.00	29.70	29.60	21.30	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-8.81	0.72	-4.28	2	10	2009-09-11 09:12:47	2007-05-11 10:17:06	5	1	10	4	2	7	0	60.00	48	94.94	CHANGED	ASKKVHQINVKGFFDMDVMEVTEQTKEAEYTYDFKEILSEFNGKNVSITVKEENELPVKGVE	.........h.uKKVpplNlKGhhDh-sspIpEpsK-sEppYDLsElLScFsGKpVSITIKEEsELPhc...t..	0	1	1	2
+9475	PF09643	YopX		YopX protein	Coggill P	anon	pdb_2i2l	Domain	YopX is a protein that is largely helical, with three identical chains probably complexing into a twelve-chain structure.	22.40	22.40	22.80	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.15	63	761	2009-01-15 18:05:59	2007-05-11 10:26:09	5	2	545	9	61	587	31	122.40	24	92.72	CHANGED	KFRuasctppchh.spthph...phtthhhtp.tpp.t...................................l...hQaTG..LKDKNGpEIaEGD.....Ilch....t..h..h..........................pat-sphhhhht...............................phh..h.hpspsh..EVlGNIa.ENsELLE	........................................................cFRsaspt..p...pthh...htt.hph.........pt.h.h.h.tt........t..............p........................l..hQh.TG....LKD..KNG....pE..IaEGD.....Ilph......ptt.tthh..........................................hpapcsthhh.ht...................................ph.h......h.h.......t.....pph.....EllGNIa.ENs-LLc..........................................................	2	18	46	56
+9476	PF09644	Mg296		Mg296 protein	Coggill P	anon	pdb_2i15	Domain	This protein of 129 residues is expressed in bacteria. It consists of three identical chains of five alpha helices.  Two copies of each chain associate into a complex of six units of possible biological significance but of unknown function.	25.00	25.00	113.30	113.20	20.20	18.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.66	0.71	-4.26	3	8	2009-09-14 14:07:04	2007-05-11 10:29:33	5	1	8	3	3	5	0	116.10	52	95.77	CHANGED	KPQLlAaKpFLQTEFpcVDFETFRpNFNLCLEREQcTllIYEDDDYDDQsFFhKPMLSDuFFIpoEVIKQL.DaLAcLV-NPKDDDKpCC...QsFYEALhlFISALAITKGIslsRaHQpLssR	p.pL.thhp.lpp.hpclshEphhpNaNhhhEppppThlhY-DDDY--.sFF.Ksh.u-h.alpsclIppl.DaltcLlcs.hDDDKphs...ppFYp....hhpAlAlTKsIslpRhpphLtsc	0	2	2	2
+9477	PF09645	F-112		F-112 protein	Coggill P	anon	pdb_2cmx	Domain	F-112 protein is of 70-110 residues and is found in viruses. Its winged-helix structure suggests a DNA-binding function.	22.40	22.40	22.80	45.00	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.57	0.72	-4.17	2	4	2012-10-04 14:01:12	2007-05-11 10:36:56	5	1	4	1	0	5	0	93.00	37	97.64	CHANGED	QolN..chAp.haphLccKtElThEDIlA.aplosssAYsI.psLKshCppH.sECps.h+sRKTs.......................................IhuKQ	....lNshphAclhaKILppKtElolEDIlAQFEISsosAYsI.+sL+hICEpH.-ECpsppKsRKTlhh.hKpEphppptpEp..ppItKIhsAps...............h...	0	0	0	0
+9478	PF09646	Gp37		Gp37 protein	Coggill P	anon	pdb_2gjv	Domain	This protein of 154 residues consists of a unit of helices and beta sheets that crystallises into a beautiful asymmetrical dodecameric barrel-structure, of two six-membered rings one on top of the other. It is expressed in bacteria but is of viral origin as it is found in phage BcepMu and is probably a pathogenesis factor [1].	20.50	20.50	21.00	21.70	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.56	0.71	-4.74	13	105	2009-01-15 18:05:59	2007-05-11 10:50:08	5	1	99	6	20	81	0	141.20	42	92.06	CHANGED	llsRL+ppLPphplEhFP-cPscYpLsHssGAlLluYtGS+FspPcDTsuVlQsRplplulTVlhRpLsucpGAlssLDplRpsLsGF+PPsC.pchaLlsEpFlG..EssGLWQYsL-hsTETltlE-s-spssPhLspVs....YEcp-	.............................VhsRL+Et.P.p.hp.lch.spcsppYh.sp..uslLlpYsGSpFscP-sTsAllQpQplplssTVlstQlsst....tAls......sLDplRpuLGGap.PsC..cR.lWLppEpalG..-ssGhapYsL-hsspolFIt-p-s.pcu.PLLTtVN....YEE.................................	2	5	15	17
+9480	PF09648	YycI		YycH protein	Bateman A, Szurmant H	anon	Pfam-B_6483 (Release 21.0)	Family	This domain is exclusively found in YycI proteins in the low GC content Gram positive species.  These two domains share the same structural fold with domains two and three of YycH [2] Pfam:PF07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.	25.20	25.20	25.30	25.20	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.50	0.70	-4.90	33	732	2012-10-01 23:24:42	2007-05-13 16:43:49	5	2	721	12	94	434	1	224.20	27	82.91	CHANGED	psp.sssppssttlppchcs-pIslss.lsscp.....scshhLsucpcshp..hcshps.....Lpspssshppps........plpushspslpls....................tppttpplpsalp...........pplhpG.....pcYpasph.p....sssplsatQpacst.la........spp....uplphplsscs...clsuYpQohlsclp.hc....c+.pplIospcAlpsLYh..pspltsssc...lppscLGYh......pll..sssspplh.sPsWpltlcpp...s....tthphhhVNAh	......................................................................................................................................................p.......ppps..h-pphpp-pIshs.s..lsscs...hph.hlsucspsFs....tcshps.............lt...spshphpsts..................phLpuslsp.slt.ls..............................cpshccl.pcalp...........pplhpG.......................pcY..p.hsph...................sssplhatQ.p.Y..cshPlh..........ssp......A..hls.h.plppcs...cls..SYp..Q...o.hhs...clc.hc.......c+...pplIospcAl.-sLYh.......ppt..lpp..ssc.......VhpscLGYh.......sll....ptsss...plh....hPsWplplcpcs.......tpsphhhVNAh..........	0	30	60	76
+9481	PF09649	CHZ		Histone chaperone domain CHZ	Wood V, Coggill P	anon	Wood V	Domain	This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones [1].	23.30	23.30	23.40	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.84	0.72	-4.72	25	201	2009-01-15 18:05:59	2007-05-14 09:24:18	5	1	169	1	137	189	0	37.30	40	13.89	CHANGED	---sD-LppIDsuNIIosGRRTRGKsIDFspAAcclps	................c--p--Lt.pIDsuNII.o..uG.RRTRu+slsastsupph......................	0	29	66	104
+9482	PF09650	PHA_gran_rgn		Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded by genes involved in either polyhydroxyalkanoic acid (PHA) biosynthesis or utilisation, including proteins found at the surface of PHA granules. These proteins have so far been found in the Pseudomonadales, Xanthomonadales, and Vibrionales, all of which belong to the Gammaproteobacteria.	20.50	20.50	20.50	20.90	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.58	0.72	-3.88	24	217	2009-01-15 18:05:59	2007-05-14 11:17:44	5	1	213	0	80	187	38	89.10	29	90.59	CHANGED	IcIcRpHsLshppARptA-plAcclspcaslcspWp....uDplpFpRoGlcGplplsssplclplcLGhlLpshpupIcpEIcctLDphL	...............................Iplc+sHsLGh-pARp+s-ph...sp+ls...p...c.....a......u.....l.....ppp.....Wp.........GDpl..ph....p.....tp....G....l....cGplsltscplclplcL.shlL.ushpstlcscIc+hLcphh.......................	1	18	39	60
+9483	PF09651	Cas_APE2256		CRISPR-associated protein (Cas_APE2256)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a conserved region of about 150 amino acids found in at least five archaeal and three bacterial species. These species all contain CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In six of eight species, the protein is encoded the vicinity of a CRISPR/Cas locus.	24.80	24.80	25.00	25.10	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.74	0.71	-4.45	28	119	2012-10-11 20:44:46	2007-05-14 11:35:42	5	3	97	2	56	125	1	135.30	23	39.62	CHANGED	cpsSAELNulhphhppt.hs.......phhLlsoDTssGchsApllccalpp............puhp.Vplht..t....lpshs.hcp..Fpc......GLtsLlctlspplp...ppsutp.lhlNsTGGaKspsuahsllu.h..husslhYlaE.phs-llpLPhl	................................................................phSAElsulhph......hppt.ht.........plhLlsoDT.pGchsucllppalpp...................pshp..lphhthts....lpsps...pp....Fpp...Glts...Lhctltpplp...ppp..u.tp..lhlNsTGGaKu.ssah.slhuhh...huh.lhYlaE.p.hscllplP...............	0	32	43	49
+9484	PF09652	Cas_VVA1548		Putative CRISPR-associated protein (Cas_VVA1548)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents a conserved region of about 95 amino acids found exclusively in species with CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats). In all bacterial species that contain this entry, the genes encoding the proteins are in the midst of a cluster of cas (CRISPR-associated) genes.	25.00	25.00	33.10	28.10	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.07	0.72	-3.98	6	31	2009-01-15 18:05:59	2007-05-14 11:44:26	5	4	27	0	10	31	1	91.80	41	51.20	CHANGED	WhloRHsGAhEWAtc....QGlclD+hVs.HLc...htclstGDpVIGoLPVpLAtslCc+GucYaHLsL.clP.plRGpELoA-phcussA+LtcacVcps	.....aFloRHsGAl-Whtp....p.G.l.plDchls.HLD...sspIpsGDsVIGTLPlpLAAclCp+GA+ahaLoL.slPhchRGpELos-phpstGApLppaplp..h..........	0	4	9	10
+9486	PF09654	DUF2396	CHP02652; 	Protein of unknown function (DUF2396)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These conserved hypothetical proteins have so far been found only in the Cyanobacteria. They are about 170 amino acids long and contain a CxxCx(14)CxxH motif near the N-terminus.	19.60	19.60	20.70	182.80	18.70	17.70	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.07	0.71	-4.26	7	46	2009-01-15 18:05:59	2007-05-14 11:53:07	5	1	43	0	20	48	1	160.70	74	95.31	CHANGED	PIFGPEIpCPHCRQsIPALTLTDTYLCsRHGAFEAsPcTt-LVHLQSGRpWRLWEspWYRQHTHPDGIRFEIHEALDRLaTQGYRAT+VIIAcRYR-LlssYLERsssh...usscss..RLYGLPVEFSssssp-.....spWpVINF-LEKE.GsshRYPYFRL..F-	PIFGPEIpCPHCRQsIPALTLTDTYLCPRHGAFEAsPcTsELVHLQSGRHWRhWpsEWYRQHTHPDGIRFEIHEALDRLYTQGYRAT+VIIApRYc-LlSsYLE.RsosWR.......up..s..-us.PRLYGLPVEFSP-spc-.....PCW-VINFDLEKE..PGlPh.RYPYFRLF-......	1	3	17	20
+9487	PF09655	Nitr_red_assoc		Conserved nitrate reductase-associated protein (Nitr_red_assoc)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are found in the Cyanobacteria, and are mostly encoded near nitrate reductase and molybdopterin biosynthesis genes. Molybdopterin guanine dinucleotide is a cofactor for nitrate reductase. These proteins are sometimes annotated as nitrate reductase-associated proteins, though their function is unknown.	25.00	25.00	73.40	73.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.85	0.71	-3.86	25	124	2009-01-15 18:05:59	2007-05-14 11:57:37	5	1	119	0	43	126	32	144.80	46	92.10	CHANGED	hFpFEpDFlssLRCIPMsVRhKLDhsGlKLKLsHWtpLopppRptLVchPs-sssplp.saRptLpphspshsss....scsLs.-ssP.sWppssplPptl....pppApphGlt.lolsQWssLssLQRFALlKLoRsGH-N+NhhsAhpEF	..hFsFEt-.s-sLphIPMlVRapLDphGl+lpLppWphLshE-RphLschPs.-..............ssst.......lc..sacctLhchlps+uss....sphh..ts-ppP.uWpsssslP-ul....hppushtGls...o.hsQWtpLsPhQRasLhKLSRps+t.N+sFlPAh+EF....	0	5	22	33
+9488	PF09656	PGPGW	CHP02611; 	Putative transmembrane protein (PGPGW)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are putative Actinobacterial proteins of about 150 amino acids in length, with three predicted transmembrane helices and an unusual motif with consensus sequence PGPGW.	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.50	0.72	-4.67	29	301	2009-01-15 18:05:59	2007-05-14 13:06:46	5	7	274	0	124	284	202	51.40	35	34.98	CHANGED	RsslsllGhsllllGllhlslPGPGWLllhhGLulLupEatWA+RhLchscpp	..........p.hlhllGhhlllsGllhlsl..P.G.P.G.aL.hlh.lGLu.l.LuhEa.WApphLthspt...................	0	46	90	111
+9489	PF09657	Cas_Csx8		CRISPR-associated protein Csx8 (Cas_Csx8)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes proteins of unknown function which are encoded in the midst of a cas gene operon.	25.00	25.00	32.30	32.30	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.61	0.70	-5.76	3	31	2009-01-15 18:05:59	2007-05-14 13:13:45	5	2	26	0	3	31	0	380.60	38	92.76	CHANGED	FDTsLEuSDWRaSATIVGLIpYFcaL-pcY.hcK.pl.ElEDDYLLYNSssINEENYLDFVEKaY....cDsLHHKlVENILp+.-ElTEEpIKlINEKLsANTlMKKlFGKIKFDGTNK-EILDLI-KNRacLIKETFRRKKsLYuNYuNTNpLFsD.sNcsCRLlGYChDsGKKGKSTGYNFssSTF-apD-KIFDFIPFAFoG.SaEAFFINDNloIccLK........................KSNchIpcKhp--hEGppNScssRpTLFsslpEouDYIKaDVEVILKsRDKEYFETlYlRcESIcIFKE..sEDF-YKuI+F.aKlTDKYYhNlpcEVssuILNslLLDslIElLLK-KNs................aSYsIppLIKINsLIRcGGKEMcE+LKuAa.ACAKpVsKKl..cNppNKLsSYKQKLlSSVlFKD+DRlC-ILLQLSsYSGVhFuFAYDLaEDFEpNKDLAYTFINAL	.........aDptlpsSDW+aSAAIsGLhhYhp.hphpa................h....pt..p...chp-....salhYsppsI....s....Ec.p...YLpFlEcaa....p-phhH+tlEs.Lpp.ppFo.E.IK.Ip-phpANolhKKlFtphKFsGpNccElLpllpcNR..lI+ETFRNtKshYsNasp.....splhpc..pppsCRLhGYhhD.s+KsKuhuasFspsohsa.D...FDFIPFAFot.sh-shFlNsNhslchL.........................Kppptlt...p...pp.hc.t.tp..pphsh+p.hht.hpc.pscaIcashE.....lIhKsp........-c..c.Y.FEThalRpcuIclhcp...hcchp......hhs...lph......Khs-ph....YhslhpEVhssILNh.hLsp.....I.....hLLK..-.cps...........................hsYh.IppLI+lN.hIhp.....ts.ppMp..p.......phctu......h.AsAtpVscKh......st......NKltSY+pKLhSsllhKsacRhhplLhQLSsYSsV.FsFsaDh.hEs.ppNcslhahFl.tL.........	0	2	3	3
+9490	PF09658	Cas_Csx9		CRISPR-associated protein (Cas_Csx9)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes archaeal proteins encoded in cas gene regions.	25.00	25.00	26.30	25.80	22.20	21.80	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-11.97	0.70	-5.65	3	8	2009-01-15 18:05:59	2007-05-14 13:47:11	5	1	8	0	6	9	0	349.00	46	88.05	CHANGED	MSWVVMDAGLEPDcEELADALEGALcSLcSRs+INTSKIGRNDRNSFD+VLpAWFGRSAPETYGELFELVIsETIKLLR-GKIDPucSLSTIKTDKNGTYLGlAYNGEQAILPAIIKQPEYYEaQSuFLKPTTGQKAQIRMDPLWFSFMALGFFTSFAGFIuGKYYLMTKPGIEVFWPYEVEEIIE+GILPLTuAGASGRISLoTEELYEMKLAMKLAEEGRcVIEEVYPVTLHlISLEGQVYTELKTlQLNLpELSNYlsEYVKKIEuu+VGGlsLLVELKEGsATlcKYPLWALVDIAEKELWKGVsGDcEMLAYIFVKDLYRAINSGRKELIcDSIFRLFRQGRALLEGSGRASGEFRKVMRTFMWEEHLEVLL	.......hSWlVh-AGlEPDpp-LA-ALEsulcoLcpRh+.hsoS.....KluRNDRsSacKVhpsW.....FshpsPETYsELFELlIcETIKLL+csKIDPucSLpoIKhDKNGTYLGlsYNGp.AILPAI.IKQPEYYEaQScFLoPTTGpKAQIplDPLWFSlLAlGFLTuFAGaIGGKYYLMTKPGIEsaa..........PYElE-Ilccull.LTsAGhpuRhSLpsEELYEh+LuMKLAEEt+pl.-clYPlTLHlISLEGQVYTELKTlQLsLppLspYhpcYlc+IcshphhuhslhVcLK-s....pKYPLWALlslAE+ELhKGVsGDpEhLAYIhVKDLYRAINSG++ElIcDolFRLFRQGRuLLEGp..u+uSG..EhRKVh+sFMhEcHLtVLl......	0	0	0	1
+9491	PF09659	Cas_Csm6		CRISPR-associated protein (Cas_Csm6)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	21.40	21.40	23.90	23.10	19.80	18.30	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.17	0.70	-5.83	4	211	2012-10-11 20:44:46	2007-05-14 13:59:36	5	2	187	0	24	168	0	273.70	26	89.77	CHANGED	sh-sEII..hh-sl.sspcaDlFhshFc+aLh.lpsta..-sEIlLNlSSGTPQMcSALhllslhss.shpsVQVoTPt+s.SNtu.paussp.clEphhcsN-DNcs..ss.sRshEssutshpthhlRpshhshIssaDYpuALsIlus.ppF.....l.-pl.pll......puAhhRc+L..hpt.h+s+.lhs-lh..shhpsDu.pKshpYhLhLslhtpRtplA-hlhpspshhphllcshlcc+h.t.lh.c...sc.aLsDph..pcthL.-p-splhph..Lccs...ccpshsspphLshhsalslLphhtPsppllttlpsltslpu.lRNssAHslsslspcp.hp.ht.lLStphlKph......hh.phhphppssaNhY-+hNcElhch	........................................................................................................................................................................................................................................pttlp.LlspYcYptAhplupp...t...........spph..Ll......chhhcRp....cL..............................t...pp.hl....h....s.c...hh......hh.h.pt-...........p......p..l.s.pYlhsLp......h+h+ptplhDFlRuloPhl....hhlhhph.lp..p....clP....................tcph..pt.....h...h.h.......t.thh......p.p..p....lhpt.....hp.p..........pshss..........c.t..hlthhs.hh.....p....l..l......h.t..sp.....l....hphl.p.LpphEppVRNslAH.Ips.hsE-....cl...p+s.st..h...up.t.h..........lc.l..............hp.h.st...p..t.t.h......h.aDphNt.lh...................................	0	4	6	18
+9492	PF09660	DUF2397	CHP02677; 	Protein of unknown function (DUF2397)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).	20.80	20.80	21.10	20.90	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.44	0.70	-5.90	21	146	2009-01-15 18:05:59	2007-05-14 14:13:19	5	4	129	\N	63	150	5	439.70	25	93.17	CHANGED	.hpYls.u-puspYRsIhR.sFhtttpphphhLps.--V...lstLtt.tphhsch..........t.cplptcLcQLscWGNLtsppDTu+.ssolt-Fcp++ahYQlothuhplERhltplpssh.spsu.uLpsshLcclhppLppLtphs........ps-stc........laphhpcLhssFpsLspsupsahupLtpshs.pcphcs-sFluaKcpLlsYLpcFltcLtppuspItttLtplptptlc..plLptsspt-tt.st............................s........................shtcthschts+WpuLpsWFlupsu.csspschLpctsppAIspllpslpRlsEp+sstssRcs-hcpLAtWFupsss.-pAHcLhsssFGltpsRHLpss.......stc.ssshssuha-uPPlclshphRppGpttppspsutl.D+stp+cthttphtpcppptctthppL..sssstlclupls..LsspshphhLplLucAhs.......p.....ttsspo-sshplpLp.hss.sphshlcoscGsLphs-ahl	...................hpYLs.s-ss.spYRhIhR.hFhtth.p+h.phhLh..--V.......hphlpp..shhtch..........s.-phppsLppLsc...Wt..NL.st...pDs..u+.spTlpEa..cp++ahYpho.huhplcRhlhplpphh..ttsu.uLpsshhcclhppLppltphh...........ptstpc................................................lhphhpcLtssFppltpsspcahupLts..............hhs....pp...h.psctFlhaKcpLlpYL....ppFltsLpphu.pItthlpplpt.p.tlp.....pllpphsph-hthst..........................................p..............s.pphhpphts+WpuLptWFhu.pss..t.spsptLtptspphItplhthstclsEpppttssRpp-hhpLAphFsps.s...ppAHpL.ussFGlh.sRHltss.......ptc.s.shspu.ha-tsPhplshp.Rppshpppt.ttsshh.Dpstp+pthhtphhppp...ppppthhtpl..hpsstlchs.pls....lsstspphLLphlucAhs............p.......tttsps-suhphplp..ts...tptshl+stcG.pLphPshhl.................................................................	0	24	50	58
+9493	PF09661	DUF2398	CHP02678; 	Protein of unknown function (DUF2398)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Betaproteobacteria).	22.20	22.20	22.30	23.80	19.90	22.10	hmmbuild  -o /dev/null HMM SEED	368	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.99	0.70	-5.73	18	150	2009-09-11 13:39:07	2007-05-14 14:29:58	5	4	127	0	66	155	4	340.50	24	84.48	CHANGED	lRsLLspPhlsp.sp-sEhathV+Rc..pstL+caFpcchGapLlVss..phARLtKhPssspsshshtch......hps+cYshLCLsLAhLEs....sspQhsLucLs-plp.Atss-sshs.....hshsshscR+ulVpsL+hLlslGllptsDGct-sFspcp.....s.u-sLY-lsttshthLls..hsps.uph............pshs-hs.pcshssssttpst..........RpRlhR+Ll.sPVlahc-Lssp-hsYLpsppp.tltcclp-hhGhhhEhRuEGlhhl......cs-c.phssshaPcsu........o.lucssLLlsptltpch...t.sphsts...........lstsclpshltcltpc...asssWp+..ttcstu.scLscpllshLpphtLl.........pt.s-t..lhhhPAsAR.......ausph.ss	.............................................hchLLpp.hlhp...tp..-.-ha.hl+..cp..tptL+cahtcphGapLllss..ths+LtKhPsps.c.s...hhshtph.........p.hcYshhC.lhLAhLEc.......stpQhhLupls-hlp..sths..t.t................h-hsthpcR+uLVcslchhhphGllphsD....Gst...-taspst.......s.s-sLY-ssthshhhlhs..hspshtph.....................................................pphpshh.pp.ph.s.sp...pt.pt...hh...........Rp+lhRpLl.sPsVYh..p..chssp-hhYlpp.+t..tltp.clpchh.Ghthch+tpuhhll........sps..phhs.hFPsps........s.hsclsLLlsthltpph.................th.....s....h.......................ls.tphtthltcltpc...htshWt+....hpths...tplhppslphhpphthh...................................ph.tct...lhhhPhhu+htst...t.......................................	0	23	51	60
+9494	PF09662	Phenyl_P_gamma		Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this protein family are the gamma subunit of phenylphosphate carboxylase. Phenol (methyl-benzene) is converted to phenylphosphate, then para-carboxylated by this four-subunit enzyme, with the release of phosphate, to 4-hydroxybenzoate. The enzyme contains neither biotin nor thiamin pyrophosphate. The gamma subunit has no known homologues.	25.00	25.00	26.60	26.50	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.82	0.72	-4.27	2	10	2009-01-15 18:05:59	2007-05-14 17:47:31	5	1	5	0	1	10	0	81.30	43	96.10	CHANGED	MNQWEVFVMD.AELPEGppLELSVRTLNPGLKKYTYQRV+AElSsALDKFPDpLQVRhGRGQLssQpFSIRIIEpVQRMPAKYL	...........................M.pa-lFl.sLsELsEGpELELpVRDLTPGlHKYsa..+hVKApVSucPcsaP..-+LhlRFGRGQhpspsaSI+llpclp+hPt+aL......	0	1	1	1
+9495	PF09663	Amido_AtzD_TrzD		Amidohydrolase ring-opening protein (Amido_AtzD_TrzD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are ring-opening amidohydrolases, including cyanuric acid amidohydrolase (EC:3.5.2.15) (AtzD and TrzD) and barbiturase. Note that barbiturase does not act as defined for EC:3.5.2.1 (barbiturate + water = malonate + urea) but rather catalyses the ring opening of barbiturase acid to ureidomalonic acid.	25.00	25.00	31.10	94.90	20.60	19.80	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.12	0.70	-5.88	10	66	2009-01-15 18:05:59	2007-05-14 17:49:48	5	2	60	0	33	66	9	335.60	48	98.20	CHANGED	s-VaRlPhcuPuDVSGLAsLI-sGtlcPscIVAVlGKTEGNGCVNDFTRsaATpuLpslLuc+lshu.cEV.s+lAhVMSGGTEGVLSPHhTVFAt+cspcssps...s+RLAVGhAhTcsLLPE-LGRtsQlscVAAAV+sAMcDAGIsDPuDVHFVQlKCPLLTscRIpsAcuRGcslATcDThcSMuaSRGASALGlAlALGElsuuploDpslhpDauLaSsVASsSAGVELhcsEIIVlG.SsshuGcLsIuHAVMpDAIDscuV+uALcclGLtss.......sscttuRLVNVFAKAEAussGpVRGRRHTMLDDSDIssTRHARAsVGGVlAulsGcstlaVSGGAEHQGPsGGGPVAVIAct	.....pVh+lshpuPuDsSuLtthIssGhlpssclVAllGKTEGNGsVNDaTRthAstuhppsLup....+hshs..p-.......V.pplshVhSGGTEGVlSPHhTlFspp....ss.s.sstt.ss....ttRLslGhAhTcshhPE-lGRhu.lpcsAsuV+pAMtcAGIsDPuDVHaVQlKsPLLT.ppItsApuRGpsssTcc....ThcSMuhSRGASALGlAVA....LGElshs....hsD...pslhpDhsLaSulASsSuGlEL.cspllVl......GNutshuGphtIuHuVMpDAlDhsulhtAlcshGlp.s.......ts.ts+lVsVFsKuEAsssGplRG+RpsMLsDS.Dl.p.pRph+AsVGGlhAulsGcsslaVSsu..ApHQGPsGGGPVAsIsc.h...	0	14	28	29
+9496	PF09664	DUF2399	CHP02679; 	Protein of unknown function C-terminus (DUF2399)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Beta-proteobacteria). Just the C-terminal region is ioncluded here.	20.80	20.80	20.80	20.80	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.05	0.71	-4.35	17	184	2012-10-01 21:47:57	2007-05-14 17:52:04	5	5	172	0	66	266	4	144.40	25	38.01	CHANGED	hpLoLRpltphts...shsspup........VaVsENPsVhushhDp.....s...........tssPLVCTsGpPssAshtLLstL..sssGspLtYpGDFDhsGL.tlAsplhpRasscP..WRhsssDY........htussssslsspsls......ush.spLspshtppuhsshpEtllstLlsDL	.............................................................h..lsLhpltth.t.....h.s.sspt........lallENsuVhst..hhpp......t..................tshsLlCs...sGp..ss....h.u.s.h.hLlctL........tts..G..s...p....lhY..p..GDFDstGl.tIAspl.....h.......p....p.....a..s.....t.....p.......a+hsspsY.............................hts.h.s.t...t.......h.s.tp......p...hp..h..t..tl......s.....s.........tlspthpph....thsshpEtlht.hh..................................................................	0	29	51	60
+9497	PF09665	RE_Alw26IDE		Type II restriction endonuclease (RE_Alw26IDE)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this entry are type II restriction endonucleases of the Alw26I/Eco31I/Esp3I family. Characterised specificities of the three members are GGTCTC, CGTCTC and the shared subsequence GTCTC.	21.50	21.50	22.20	400.30	20.90	21.40	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-13.08	0.70	-5.79	7	16	2009-01-15 18:05:59	2007-05-14 18:17:05	5	1	14	0	1	14	11	493.30	51	93.32	CHANGED	cPpFl-Yh+hIlpHPNYtGMPsshttcGcIpWpssSs+poG.Fhph.ppRhtWWcpKAcplGls..sspsthhopsA+hIHPTthKPC+hCG+.hslsYhYPs+shhp+lpK.....-pF.l..sp.ppIsclhspLhphhu-phhpph.thlhscth.phschsssh-talp.l.ppalspt.phLSPGsMuNsPDRhDGFHoaNtCCRuppDpGRpcENL+SYopDRRuFEaWsDGsWsAADpLM.....Gphthssphh...pl............SADHIGPISLGFsHcPpF.p.hCpusNSuKNsRhhhsDlppLlchEs.pucsVuSWasctlW-hhKcsV......sss-sshp..hSphLRsNpchahplLhclhp....sGpthhLushLp.cY.....ApashsF-slphpsphhphpslpp.p+hTchsptppsRtlRIAFEuLp-YspK..EsRphhts.s....cp.pphls.hhp.lp........hhs-plsp.lppss.p-c.hpslh...........tp...h+chLhphMshluccltp	..stFLEYs+hIVsHPNYhGMPDshGccGcIQWEAPSNRuSGpF+cTaQ+RhcWWcsKA+SlGID..soEpuWISKTAKLIHPhGhKPCKpCGKpM-LuYuYPNcpFhuRl+KLsYlDEoFEL..opsEHIlDLlsRLccpaGEcla.DLP+LhssKol.sIPcloSsL-sWIcaLcEpYIPpEu+hLSPGAMANPPDRFDGFHSaNRCCRShADKGRoKENLKSYsTDRRsFEYWVDGDWVAADRLM.....GplRo.NNhhh....pEECLNsst....PsPCpADHIGPISLGFuHRPpF.QhLCKSCNSAKNNRMYLSDlhpLL-AEN.EGcoVhSWaucclWs+lKHoV......cDsEcAlR..LSKlLRDNRHTYMpLLc+Ihc....-GaasFLAolL+LEh.....ANYs.hFEGLsISNHlTcYcSl+K.++pochsthpcsRplRIAFpuLp-YtpK..ENRNshhVss....c.ppphhschh.ppLpuhsp.h..ppLs-tlst.l.pp..pcpphpslhptl....h..t.cpaphhhchL.phhs.lGcpht.s.....................	0	1	1	1
+9498	PF09666	Sororin		Sororin protein	Bateman A	anon	Bateman A	Family	Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion [1]. The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex [1].	23.00	23.00	27.50	27.50	19.40	18.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.09	0.71	-4.05	14	61	2009-01-15 18:05:59	2007-05-15 14:10:46	5	2	42	0	29	58	0	126.90	37	35.78	CHANGED	ENhPP.........hsppshhhssstsspssps.V.lPsstcolQp+ushcslsIl.......WpKpV......cpo.oR.phs..............................ts.pssoPp...tp...............s+psLFGFEchLssE....-h..spssspu+sts.psVo............hpchsp.tssscslPtVs..sh+c	.........................................ENtPP.......p..hppsh.t...sps.sspssps.V..s..hco.ppc.s..hcshsl........MSKKV......RRSYSRLps...............................tsssTSTP.....................uRRShFGFEshLssE....DL.tsuslssSKhhpsspVs................scshsPDpsLPGlSsss.+.....................	0	3	5	12
+9499	PF09667	DUF2028		Domain of unknown function (DUF2028)	Bateman A	anon	Bateman A	Family	This region of similarity is found in the vertebrate homologues of the drosophila Bobby Sox.	25.00	25.00	31.90	28.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.07	0.71	-4.09	3	80	2009-01-15 18:05:59	2007-05-15 16:21:03	5	4	40	0	31	87	0	124.30	72	15.86	CHANGED	EMPQLNFuMADPTQMGGLSMLLLAGEHALTo................PEVSSGICR.s.St.Pp.ppKSsLFpFsElSSSTSHSDsPAssKQspTSALFQ..FAEISSsTS.sQl+sA-PVKRCGKSSL.............suusptK.CtpSALFQLAEMCLASEAsKMEpS+slcsD-S	..............EMPQLNFGMA..DPTQMGGLSMLLLAGEHALGT................PElSSGTCRPD..lSES....PELRQKSPLFQFAEISS.STSHPD..AsoKQCQsSALFQ..FAEISSNTS..QLGGsEPVKRCGK........................................................SALFQL..AE.................M...CLASEGhKME-SKLhKuKES.................................	0	2	4	14
+9500	PF09668	Asp_protease		Aspartyl protease	Mistry J, Wood V	anon	Pfam-B_9589 (release 20.0)	Family	This family of eukaryotic aspartyl proteases have a fold similar to retroviral proteases which implies they function proteolytically during regulated protein turnover [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.50	0.71	-4.55	12	445	2012-10-02 15:32:34	2007-05-16 13:33:18	5	22	263	6	291	833	24	118.70	41	29.40	CHANGED	ppplpENhppAhEapPEsFupVhMLYlssclNGh.VKAFVDSGAQsoIMS.cCAE+CGlhRLlDTRatGlA+GV.Gst+IlGRlH.splKlGs.halPsuhoVlE.spclDhlhGLDMLKRHQssID	.....................................ptlp-shp..A.hE...tPEsF.s..p..V..s...MLYlssclN.Gp.s.l.K.AF.V.DSGAQ.hT.IMStu.CA..-..+..C...s..l..h...R..L...l.D.p..R.at..G..l.A..p..G..V.....G..o..t..c..I.l....G..+.l...H........s.....pl..p...lts....a.l...s...C......SF.s.V..l.-........s.........p.......s..h....-..h.LlGLDhL+RHpssID............................................................................	0	105	148	212
+9501	PF09669	Phage_pRha		Phage regulatory protein Rha (Phage_pRha)	TIGRFAMs, Coggill P, Iyer LM, Bateman A	anon	Iyer LM	Family	Members of this protein family are found in temperate phage and bacterial prophage regions. Members include the product of the rha gene of the lambdoid phage phi-80, a late operon gene. The presence of this gene interferes with infection of bacterial strains that lack integration host factor (IHF), which regulates the rha gene. It is suggested that Rha is a phage regulatory protein.	28.20	28.20	28.60	28.30	27.70	27.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.13	0.72	-3.63	122	1673	2009-01-15 18:05:59	2007-05-16 13:38:50	5	20	1017	\N	171	1330	10	87.90	27	38.68	CHANGED	ssoShclA-hhsKcHcsVlRsIcphh...........................t........sths.a.tthp.t....s.spspp...hYhl....s+cshhhLlhuao.sttshpa+...tthIctF..pchEp.pl	....................hsoShplAchh...........sKcHcsVl+sIcplttt..............................p..h..sphs.a..psphh...........s.sp.s.cp..h.hYhl....s+cuhhhLlhuho..stts.h.pFK...tth...lptFppMEpt.....................................................	0	39	110	141
+9502	PF09670	Cas_Cas02710		CRISPR-associated protein (Cas_Cas02710)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are found, exclusively in the vicinity of CRISPR repeats and other CRISPR-associated (cas) genes, in Methanothermobacter thermautotrophicus (Methanobacterium thermoformicicum), Thermus thermophilus (Deinococcus-Thermus), Chloroflexus aurantiacus (Chloroflexi), and Thermomicrobium roseum (Thermomicrobia).	22.40	22.40	22.40	22.40	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.34	0.70	-5.83	10	109	2012-10-11 20:44:46	2007-05-16 14:25:52	5	5	85	0	64	132	12	269.30	16	69.90	CHANGED	-slthuIsshpP-+VlFLso...............-pScsp..lscl+...cpsstpspp.........hhshstDssslhcsYcchcsll-+a...thcccplllDhTGGTKsMouGLslAuhsh.....chshsYVsG....csssG+lpsGoE+lpp.psPassauclEtcpAtpLaN+tcauuAhplhcsLspR.lsccps..YshhttLscuYhtWDpFcaccAh-tLc+shsp.sl...........sscppsLpphsslh+sLpshLssttsshsth.c...shsLltDLLuNAcRRAupt+YDDAuhRlYRsLELluQtcLt.shGlsTusss.....hhpclP-tLcpsYcptpsspGht.........h+IuLhsuYtLLpshGDc..lucpa.....htphsclpphlpsRNpSILAHGacs....loccpYcpltDhlpshhpth	.....................................................................................................................................................................................sltth..pP..ctlh.hl.ho....................................ppstth......htp...lh......p.h..th.t.tt.........................hhhh.hs.psh..p....h.a.ct.lpph.lpph........tt..t...pl.hlDhTGGTKsMusuh.s.huuh.h....................sh.p.h.Ylsst......p.t.tps..stp................................................................................................................................................................................................................................................................................................................................................................................................................................h..................................................................................................	0	27	45	60
+9503	PF09671	Spore_GerQ		Spore coat protein (Spore_GerQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this protein family are the spore coat protein GerQ of endospore-forming Firmicutes (low GC Gram-positive bacteria). This protein is cross-linked by a spore coat-associated transglutaminase.	25.00	25.00	65.90	65.60	24.10	20.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.69	0.72	-4.33	19	183	2009-01-15 18:05:59	2007-05-16 14:32:04	5	1	174	0	31	116	0	80.90	67	52.50	CHANGED	GMLPLEQSYIENILRLNKGKpATVhMTYEpuSphGopsasGIIEAAGRDHIVISEPpSG+RYLLLMIYLDYVpFsEEITYh	......GMLP.lEQSYIENILRLN+GKpATVhMTYEpuop..h..sspsapGIIEAAGRDHIlIS-Ppo......G+RYLLLMIYLDYVpFsEEIsY.....	0	10	21	23
+9505	PF09673	TrbC_Ftype		Type-F conjugative transfer system pilin assembly protein	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents TrbC, a protein that is an essential component of the F-type conjugative pilus assembly system for the transfer of plasmid DNA. The N-terminal portion of these proteins is heterogeneous.	20.90	20.90	21.10	32.00	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.44	0.71	-4.47	49	432	2009-01-15 18:05:59	2007-05-16 15:26:40	5	1	316	0	67	337	22	108.60	35	41.09	CHANGED	hlFlShSMPppuL+phhppspph....ssslVlRGhhss...shppThstlppLhppstt.............ssltIDPphFcpasIspVPuhVhsps...........s.spt.t.......spastltGslolphALcpls	........hhFlShShP-puLKphlt-spch.....GhssllRGhsss....sLps.TscslhsLlpcssss.............ulpIDPslFppYsIpsVPulVlhss..........................................psachlpGslplttAL-pl.........................................	1	16	35	54
+9506	PF09674	DUF2400	CHP02757; 	Protein of unknown function (DUF2400)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this uncharacterised protein family are found sporadically, so far only among spirochetes, epsilon and delta proteobacteria, and Bacteroides. The function is unknown and its gene neighbourhoods show little conservation.	21.90	21.90	22.30	32.70	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.43	0.70	-4.66	49	423	2009-09-10 16:07:27	2007-05-16 15:34:14	5	2	396	0	109	346	215	212.90	36	86.13	CHANGED	DPlplsH+apc.pDhEIuuhlsAhhAaGNtKtIlcphccL.hpLhspuPhpalhphp.....tp..hpthpsFh..aRh.supDltthhhsLpplhp..phsuLEshFt................thppssslppulppFhpthhp.h...h..hs.cal..............ssstssSAsKRlNMaLRWMVRpcs..lDhGlWcs.lssupLlhPLDsHst+lu+pL.GLhpRKpsDh+sshElTpsLRclDPpDPlKYDFALatLGhpc	...........DPlphs+hasc.......s.EhhullsAhhAaG.st+pIlphlccL.hslhs..s..s...t.h...................pcp.h.h....pphcshhYRh..stpDlhthhhsLpplhp..c...toLcphFh....................................t.h.p.p...p...p.shhpu.ltsFhpthhph......h.....hs...chh............h...pssssSshKRhNMaLRWMVR+Dp..lDlGlWpp..lpspcLllPLDTHst+luhpL.GLl......c......RK..........phDhKsshElTpsL+clsssDPlKYDFALatlG.s................	0	42	91	105
+9507	PF09675	Chlamy_scaf		Chlamydia-phage Chp2 scaffold (Chlamy_scaf)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this entry are encoded by genes in chlamydia-phage such as Chp2. These viruses have around eight genes and obligately infect intracellular bacterial pathogens of the genus Chlamydia. This protein is annotated as VP3 or structural protein (as if a protein of mature viral particles), however, it is displaced from procapsids as DNA is packaged, and therefore is more correctly described as a scaffolding protein.	25.00	25.00	47.00	46.70	22.70	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.47	0.71	-4.07	4	9	2009-01-15 18:05:59	2007-05-16 15:38:40	5	1	8	0	1	10	48	108.80	40	74.45	CHANGED	IphIVtKhNtsuslpHl....tpRpspYs-CssPhDap-ALssVhcupEtFDuLPA+lRcpFuNsPcEhLp.......aLpc.cNh-EuhuLG..ll..-........hhcst.+csp.sssQppsh	.INpIVAKhNuTGVlpHl....p+RpscYhDC.sPh-YpEALNlVhEApEtFDuLPA+lREcFuNsPcthL-.......FLsc.cNhEEutuLG..hl.t-tp......hhcst.+csp.sssQp.s.l..........	0	0	0	1
+9508	PF09676	TraV		Type IV conjugative transfer system lipoprotein (TraV)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry includes TraV, which is a component of conjugative type IV secretion system. TraV is an outer membrane lipoprotein that is believed to interact with the secretin TraK. The alignment contains three conserved cysteines in the N-terminal half.	21.00	21.00	21.30	22.20	20.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.77	0.71	-3.40	39	394	2009-01-15 18:05:59	2007-05-16 15:56:05	5	2	298	0	59	271	10	128.70	30	69.11	CHANGED	sscFuCsussus....Ctohspshppuhtt..stp.ht........................ssssssssssssssssssshsh...s..h..............................................................Pl.Rsttclh+lhlsPahDsc..GchapsshVahhlcsu...pW	....................................................................................................................po-apCsusssss...Chohcps...ctspphpt.spp.sps.sst.th....................................sss.susps.ssssp...sppthhss...cshhs..tstpsp............................................................................................................................Pl.RosppshplWIAPahD..sp..sshapsuhVahllcPutW...........	0	16	30	47
+9509	PF09677	TrbI_Ftype		Type-F conjugative transfer system protein (TrbI_Ftype)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents TrbI, an essential component of the F-type conjugative transfer system for plasmid DNA transfer that has been shown to be localized to the periplasm.	21.50	21.50	22.00	21.80	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.13	0.72	-4.23	11	206	2009-01-15 18:05:59	2007-05-16 16:16:43	5	2	170	0	26	141	4	108.80	52	83.32	CHANGED	++p.l.hl.hslshlslsshlohhlsp..sPslVsFDMKpTlsuFapSsupppLo-tppcshssRFsssLccpLptaptpH+slILVoPAVVpGAsDlTp-IQpslhcRhp	........................pphhhhlsus.LuhVlLNAAlSau.l...l..R.l.s..sP..l.....ssAFsMKpTVDAF.aDS.AS.Q.......KpLSEAQSKALSuR...FNoALEASLQuWQQcHHAVILVSPAVV.Q..G..A.P.DITREIQQDIARRM+.......	0	4	10	20
+9510	PF09678	Caa3_CtaG		Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are the CtaG protein required for assembly of active cytochrome c oxidase of the caa3 type, as found in Bacillus subtilis.	21.80	21.80	21.90	25.60	20.70	21.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.53	0.70	-5.44	106	1028	2009-01-15 18:05:59	2007-05-16 16:22:26	5	6	749	0	353	921	395	237.70	26	56.82	CHANGED	sshYhhuhh+hppp..stths...tRsshah.hGhhslhhshsoslshhup.hhFosHMlpHhlLthlsP.LLlLG.tPhslhh...cslssttt..........hh.hhhhsthh+hlspPhlAhhlFsushahaa.hsslashshpshhhHhlhphphlluGhLFahslls.sP...stphshht+lhhlhsshshpshhGshlhhussslhssaht...............................sas.h.ssltDQplGGhlhWhsGplshllshhhlhhpWh+pc	...................................h.hhYhhu.hhth+p+....spthss....tRh...hhah..hGhssl.hhshsoslshhup.hhFShHMhpHhlLthlsPhLLlLG.tPhsLhh...pslshsht............hh....h....h..pt....hhc....h....l....spPlhAh...llFlushahha.hs.slashsh.psphsHhhhphphllsGhlaaaslls..c................Ph...spp.hshht+lhhlhsshshpshhushlhhsspslhssahp.............................hsas..h.shlpDQplGGhlhWhsu-lshlllhhhl.hhpWh+p......................	0	113	251	309
+9511	PF09679	TraQ		Type-F conjugative transfer system pilin chaperone (TraQ)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents TraQ, a protein that makes a specific interaction with pilin (TraA) to aid its transfer through the inner membrane during the process of F-type conjugative pilus assembly.	21.20	21.20	21.20	21.20	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.08	0.72	-4.06	4	133	2009-09-11 14:33:19	2007-05-17 10:28:23	5	3	110	0	3	55	5	89.20	81	97.41	CHANGED	MRKhRFpLPchDITGhWVhulGlaFHIVuRLVh+cP.MAhhLAElIulhhVLaGuYRlLsAWIAcsp+EE+....ARptuhhctp.-t........+	.................hpKhRFSLPRLDITGMWVFSLGVWFHIVARLVYSKPWMAFFLAELIAAILVLFGAYQVLDAWIARVSREEREALEARQQAMMEGQQEGG....HVSH..............................	1	0	0	2
+9512	PF09680	Tiny_TM_bacill		Protein of unknown function (Tiny_TM_bacill)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of hypothetical proteins, half of which are 40 residues or less in length. Members are found only in spore-forming species. A Gly-rich variable region is followed by a strongly conserved, highly hydrophobic region, predicted to form a transmembrane helix, ending with an invariant Gly. The consensus for this stretch is FALLVVFILLIIV.	20.50	20.50	20.80	20.50	19.90	19.20	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.58	0.72	-6.85	0.72	-4.52	27	936	2009-01-15 18:05:59	2007-05-17 12:31:50	5	2	143	0	116	418	0	25.00	71	52.80	CHANGED	uaGu..GFALIVVLFILLIIVGuuah	...............GhGG...GF....ALLVVLFILLIIVGASCa......	1	27	80	91
+9513	PF09681	Phage_rep_org_N		N-terminal phage replisome organiser (Phage_rep_org_N)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents the N-terminal domain of a small family of phage proteins. The protein contains a region of low-complexity sequence that reflects DNA direct repeats able to function as an origin of phage replication. The region is N-terminal to the low-complexity region.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.27	0.71	-4.54	26	638	2012-10-04 14:01:12	2007-05-17 13:57:17	5	8	478	0	41	432	20	117.60	31	43.88	CHANGED	WIKlpsshFDDcKIKll-pMs-sDslhhIWh+lllhuGKhNssGhlahscslPYTsEhLAhhhs+slssl+hALpshpphGMIEl.h-ssshplsN..ap+aQsh-sh-ppRcpscc+hp+pcp	........................WlKLppshFcDc+I+.hlcph.s.su..s..shhhIalKLllhu..hpspGt.Lhh...s...tp...lshstc.LAphhc.cshssVchslphhp....phGLlEh..h-.s.st...hhlss..ht.ph.sp.-sstsc+cRptRpppp...h..................................	0	11	34	39
+9514	PF09682	Holin_LLH		Phage holin protein (Holin_LLH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry identifies a family of putative phage holin from a number of phage and prophage regions of Gram-positive bacteria. Like other holins, it is small (about 100 amino acids) with stretches of hydrophobic sequence and is encoded adjacent to lytic enzymes.	24.80	24.80	24.80	24.80	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.23	0.72	-3.93	13	257	2009-01-15 18:05:59	2007-05-17 14:32:53	5	1	214	0	20	171	1	103.90	41	87.97	CHANGED	Msplsp.Ilssulul.lsllsGhhs+tVhcaLhKK.GGEKss+IsEIlA+sAVsAVEQlss-su.KGp-KLspA+stlpshLsphsl.phoDsplcshIEuAVKpMNssh	......................MpplsphIhssAlul...LsllsGhl....l+...sVK-YL...hpK....G...GEKsl+Is......E..ILAKsAVsAVEQlus-.suhKGcEKLspApstV+spLs+h..sI..shTDcp.l-shVEuAV+pMNDs.......................	0	5	9	12
+9515	PF09683	Lactococcin_972		Bacteriocin (Lactococcin_972)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent bacteriocins related to lactococcin. Members tend to be found in association with a seven transmembrane putative immunity protein.	22.00	22.00	22.10	23.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.50	0.72	-3.62	6	605	2009-01-15 18:05:59	2007-05-17 14:37:33	5	1	388	0	27	146	0	60.30	44	66.27	CHANGED	V-GGhWsaGlG..usasaScYhHup+sHsuTslut..s+os+uhAcAGshu+AShsK..sh.spcsFY	...................s-GGsWsYG......G..........s..th...saSsYhH.sp..+hHsSolh.....ut.....spS.sKG.hAt.AGspShAhlhs...sW.utphAFY....................	0	10	15	19
+9516	PF09684	Tail_P2_I		Phage tail protein (Tail_P2_I)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent the family of phage P2 protein I and related tail proteins from a number of temperate phage of Gram-negative bacteria.	20.60	20.60	20.70	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.66	0.71	-4.62	49	1210	2009-01-15 18:05:59	2007-05-17 15:44:47	5	9	872	0	232	949	32	134.60	33	58.83	CHANGED	LPssu.osLE+slt.tshspl......tthPsslpsLhsPspCPsslLPaLAWuhSV...DpW-ssWsEpsKRpllcs.........Ah.lH++KGThuAlR+slcslGh..hclhEWapps........st.......PuTFplpltlppp.......slspphhtplpcllscuKPsp	.....................................................LPs......h.htht...tshstl.......pph..s.s.lpsL..h.s...P.s..sC.Ps...p....hL....PaLA.WsauV...........D.cW..-.p....s.W....sEpsKRpll+s.........AhhlHc+KGThuAl.Rcll-.s.......l..Gh....hlclpE.....Waphs.........................t.............tPsp..Fclpls.l.pp.......uls.pphh.plcclls-s+ssp..............................................................................	1	54	137	196
+9517	PF09685	Tic20		Tic20-like protein	TIGRFAMs, Coggill P	anon	TIGRFAMs & Jackhmmer:D3PVW8	Family	Chloroplast function requires the import of nuclear encoded proteins from the cytoplasm across the chloroplast double membrane. This is accomplished by two protein complexes, the Toc complex located at the outer membrane and the Tic complex located at the inner membrane. The Toc complex recognises specific proteins by a cleavable N-terminal sequence and is primarily responsible for translocation through the outer membrane, while the Tic complex translocates the protein through the inner membrane. This entry represents Tic20, a core member of the Tic complex. This protein is deeply embedded in the inner envelope membrane and is thought to function as a protein- conducting component of the Tic complex. This family also includes many proteins of unknown function from non-synthetic organisms.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.76	0.72	-4.07	122	1525	2009-01-15 18:05:59	2007-05-17 15:49:58	5	10	1098	0	439	1083	83	107.20	21	79.33	CHANGED	s-+ph.uhlsH....lu..................hh.uhls..PLllallp..+-p..ssalcppu+pulNFplo...hhlhs.....llssllshlh..........................................hhlsh.......llhhlh...........lht....llh..sIl....uul+A..ppGpha+.Y..Phs.lch....l	..............................p.h.uhLsa....hu..........................as..shls...Pllla...llp....ccp.........hlctpu+pu.l.hpls....hhlhs....llhh.hl.shlh..........................................hhlsh..............lhhhhh.........hlhs....hlh...sIh.......sslKs...ps........h..h..Ph......................................	0	153	304	392
+9518	PF09686	Plasmid_RAQPRD		Plasmid protein of unknown function (Plasmid_RAQPRD)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry identifies a family of proteins, which are about 100 amino acids in length, including a predicted signal sequence and a perfectly conserved motif RAQPRD towards the C terminus. Members are found in the Pseudomonas putida TOL plasmid pWW0 and in cryptic plasmid regions of Salmonella enterica subsp. enterica serovar Typhi and Pseudomonas syringae DC3000. The function of these proteins are unknown.	21.10	21.10	23.40	23.90	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.77	0.72	-3.90	30	227	2009-01-15 18:05:59	2007-05-17 16:26:49	5	1	183	\N	68	210	9	80.10	40	72.02	CHANGED	uuhAs....sAuE+-pLAtslRQL-tlcths....pRApssAs.ssts...Ra+FDYsRlpsDLpplRpGIppYLsPSRAQPRD...sssLsGDY	.......s..hsssuuE+pcLuhslRQL-tlctsl....pR.A...tstAs.sssp...RaaFDYsRlpuDlpplRtGIppYLsPSR..AQPRD....sssL.sGpY................	0	7	30	54
+9519	PF09687	PRESAN	P_fal_TIGR01639; PHIST_a_b; PHIST_a_c; PRESAC; DUF3837; PRESAC;	Plasmodium RESA N-terminal	Aravind L,Coggill P	anon	TIGRFAMs, Aravind L	Domain	The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc [1] has been extended to become this six-helical PRESAN domain identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. A secondary structure-prediction derived from the multiple alignment of the PRESAN family reveals that it is composed of an all-helical fold with six conserved helical segments. There is some evidence it might localise to membranes [2].	23.60	23.60	25.50	24.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.67	0.71	-4.08	162	210	2010-01-11 11:54:32	2007-05-17 16:34:49	5	7	10	0	203	264	0	125.10	16	30.63	CHANGED	phppphsccclpchlp...sltt..h...hspcchhtla.phhphp+pcahphhppLhphhpplspch.pl........sc.............chp.pchWpcspptlppphtph-pthpppFhphl..ppp...h...sttc................FhphlpphpptWcphhpphpppa	......................phpcpclpc.hlp..pltt..h...hspcchhtla.phhphp+pcahphhppLhphhppltpph....pl.........sc.............chp.pchWpcshptltpphtph-pthpp.pFhphl...ppp....h.shpc................FtphlpphpptWcphtpphppph.............	0	83	84	162
+9520	PF09688	Wx5_PLAF3D7	CHP1606_PLAF3D7; 	Protein of unknown function (Wx5_PLAF3D7)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This set of protein sequences represent a family of at least four proteins in Plasmodium falciparum (isolate 3D7). An interesting feature is five perfectly conserved Trp residues.	25.00	25.00	28.80	28.80	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.00	0.71	-4.24	8	26	2009-01-15 18:05:59	2007-05-17 16:45:06	5	1	6	0	26	33	0	139.00	23	60.31	CHANGED	acRIluE...+sp.sacp-FslthN-pp.pphpp.scpspPh..p..-pIpclspLsspsoclWK-slcsMcpcYhcpTD..pM-+pWRDtMWpp+WsK.YL-sVHspINppLN-.sholc-KEphlspWlpWsp-DacaFLphlKE-Wcc	..........................................................................t...t...pp.s......p.ht...c..hppLhhphschWcpslpsMhppYpphT-...phspcW+phMWNppWt+.YLEtlhspIspslps.shohpcpEshlpphlphspcDFphFLp.lptcWc.......	0	5	7	21
+9521	PF09689	PY_rept_46		Plasmodium yoelii repeat (PY_rept_46)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This repeat is found in the products of only 2 genes in Plasmodium yoelii, in each of these proteins it is repeated 9 times. It is found in no other organism.	20.80	20.80	22.00	20.80	19.50	18.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.41	0.72	-3.63	7	34	2009-01-15 18:05:59	2007-05-18 11:17:37	5	3	2	0	34	33	0	43.80	61	80.98	CHANGED	KSK+SRFPoMFKRDKKDK-sccu.......ts.ESLssD.....KSLEoLsDDscsp	......KSK+S+FsoMFK+DKpDK-sccu...............stSQEoLssD.....KSLEoLsDDscs.....	0	0	18	34
+9522	PF09690	PYST-C1		Plasmodium yoelii subtelomeric region (PYST-C1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This group of sequences are defined by the N-terminal domain of a paralogous family of Plasmodium yoelii genes preferentially located in the subtelomeric regions of the chromosomes. There are no obvious homologues to these genes in any other organism. The C-terminal portions of the genes that contain this domain are divergent and some contain other yoelii-specific paralogous domains such as PYST-C2 (IPR006491).	25.00	25.00	33.90	33.40	19.40	18.50	hmmbuild  --amino -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.04	0.72	-4.33	22	27	2009-01-15 18:05:59	2007-05-18 11:23:47	5	1	4	0	26	27	0	60.10	38	47.86	CHANGED	Ks.SslGN+.lRuhKcIppsNEcNsIE.KpETQLpNNNs.p.+DccDsps............KcsKcsK	......KsSslGN+.hRuhKcIspoNEKNsIE.KpETQLpNNNs.p.Ks-ccspt........cpp....t...........................	0	0	15	26
+9523	PF09691	PulS_OutS		Bacterial chaperone lipoprotein (PulS_OutS)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family comprises lipoproteins from four gamma proteobacterial species: PulS protein of Klebsiella pneumoniae (P20440), the OutS protein of Erwinia chrysanthemi (Q01567) and Pectobacterium chrysanthemi, and the functionally uncharacterized E. coli protein EtpO. PulS and OutS have been shown to interact with and facilitate insertion of secretins into the outer membrane, suggesting a chaperone-like, or piloting function for members of this family.	25.00	25.00	25.70	25.50	19.90	19.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.50	0.72	-4.05	8	624	2009-01-15 18:05:59	2007-05-18 11:52:13	5	1	539	6	60	190	1	99.80	72	82.95	CHANGED	LsGCQQsssp..sPotphts........-QlpQLuoLlAGo+YLKpcCpRSDlPD-ssIh+oAlplApp+GWssts..hptLsp+ScslYpsLhcDsTPctspCupFNpphssFI-u	.....MAlCANSYALoE...............................SEAEDMADLTAVFVFLKNDCGYQNLPNu.QIRRALVFFAQQN.QWDLS..N.........YD.........TFDMKALGEDSYRDLSGIGIPVAKKCKAL..ARD.......SLSLLAY..	0	1	15	34
+9524	PF09692	Arb1		Argonaute siRNA chaperone (ARC) complex subunit Arb1	Mistry J, Wood V	anon	manual	Family	Arb1 is required for histone H3 Lys9 (H3-K9) methylation, heterochromatin, assembly and siRNA generation in fission yeast [1].	25.00	25.00	29.60	25.60	24.80	24.00	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.43	0.70	-5.62	11	86	2009-01-15 18:05:59	2007-05-18 13:22:42	5	5	74	0	72	88	0	321.70	29	75.91	CHANGED	KKKppsK..op+sKp+.PTGFEEYYsDsPlTPsEYpEEcc.lYss......RhEcsI.Rapp+RRh.-SsRpslFsKYLshGGVDsGs+hFsG...lDpcsLpshcu-pIhttpAps.l..............spcpspasVDFsuVs+GFLophhPhhhs.psp-.lphusssl+NFLsYlLhH-VCPEYpcslctAp+hCDlApcEL.p.pphttthPG-FNsAsSoLFGtshtcha..ssuWsspccDp.hhssplARp....llpFshuutst.htshca.-hsp.sshpshplps.puaEVsslphPssss+thYpph.......hssLpPlGKLluKsahsPGhst........hDhss-p.......pssssspcaEFalE-slLphCasGMKlpssVapLNsGl+aFDplhssasSFYphLsN-LMhGWKEP	.................................................h.c..ssGFEEhhs-sPhTstEhtppcp.l...Ys..........RlEpsIpRapt+R+h.pspRtplFscYh.hGGl-sus+hFpG........spppL.......pp..hstpplhthpAp...ssl..............................stpp.pasVDFpsVstGFLSphh..hhs..s.t.hphussslcNFLpYllhH-VCPE..Yp-..slhtApplCphAppEL.tspph.tt.hPGpFNhAsotLFs.s...h...t.h.....p...pta..pt......tt........thsht......hhthhhus.st..ts..ph.....phht.pphpsh.h.p..tshElhslh.Pstthpphapph........................sssltPlGphhs+shh...............Dh.stp..................tt.phphalEcslLphhhsGMKlt...sslhcLss..G..lpahcphhshhsSFashL.p-hMhtaKpP....................................................................................	0	15	31	56
+9525	PF09693	Phage_XkdX		Phage uncharacterised protein (Phage_XkdX)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry identifies a family of small (about 50 amino acid) phage proteins, found in at least 12 different phage and prophage regions of Gram-positive bacteria. In a number of these phage, the gene for this protein is found near the holin and endolysin genes.	23.50	23.50	23.50	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.73	0.72	-4.43	23	600	2009-01-15 18:05:59	2007-05-18 13:28:44	5	2	404	0	44	281	2	39.20	39	73.28	CHANGED	a-slKphYchG..haTp-pl+paVphphITtE-YccITG.ccY	................FccIKphYshs..hY.....op-.....p....lthaVsh..t..hITcEEYppITGccY..........	0	22	35	39
+9526	PF09694	Gcw_chp		Bacterial protein of unknown function (Gcw_chp)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a conserved hypothetical protein about 240 residues in length found so far in Proteobacteria including Shewanella oneidensis and Ralstonia solanacearum, usually as part of a paralogous family. The function is unknown.	20.40	20.40	20.40	20.60	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.52	0.70	-4.56	7	705	2012-10-03 17:14:37	2007-05-18 13:31:32	5	2	422	0	274	695	451	214.20	22	85.19	CHANGED	tApsuSPhohSuNluLsSpYhFRGlo.ost+PAlQGGhDhuH.SGFYsGsWsSols....ssssshu........ssEhDlYGGass..slGt..hsaDlGlhtYhYPGupsss....Y...hsEhhuuluat.l...sh+hsau.s.s.hG............pSpsstYlshssshsls.sshThhAHlGhpcst.h.ss...uasDW+lGho.+shssshshustYhDspuc.sh............u..ts.shscsshhsolstTF	..........................................hs..........ph..ous..lsh..s..SsYha.RGloQ...........o................s..s.....p.....PAl....QG..Gl....-....hua....s....u.....G.a..Yl...G.sWuS..s..l.................sh.ss.ss.........................s.hEh.DhYuG..Ypt.....ph.s.s.....hshDlG.l..h.tY.....hY.....P......us..s..............s...s..s......................................................hsE.h.h....s....s....l..u...a...s....s....h..............pht..h...s.h..sh...s...........p..h.......h..G.................................psps.s...h...Y...h.p........h.s......h.shs.....l...s..................s....h...s...l...s..s..p.h..G.........ap..p..h........p......s..................st.................sa........Dapluls......tth................s..hshsh..thhs.ss......t..t.......................................................................................................................................................................................................................................................	0	64	153	218
+9527	PF09695	YtfJ_HI0045		Bacterial protein of unknown function (YtfJ_HI0045)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These are sequences from gamma proteobacteria that are related to the E. coli protein, YtfJ.	21.70	21.70	22.10	21.80	21.10	21.60	hmmbuild  --amino -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.80	0.71	-4.90	26	1008	2012-10-03 14:45:55	2007-05-21 11:22:22	5	2	724	0	68	382	31	154.40	61	86.22	CHANGED	lplupplPsVsVs-cGELhLps..sphuYpsWsSupLsGKVRVlQaIAGRoSAKEhNusLhpAIpuApFPc-+YQTTTIlNpDDAIaGTGsFV+SShEcuK+-FPWSphVLDppGsVppAWpLppcSSAIlVlDKpG+VhFsK-GuLossElppVlsLl+p.	..................................................................h.psGppVPPVuIs-+GELlLsp..DphsYpsWNSuQLsGKVRVlQHIAGRoSAKEKNAsLIcAI....cuAp.h...PpDRYQ....TTTIVNTD.DAI.GoGh.FV+SSlEsNK+hYPWSQFllDuNG.l.u.RsAWpLs..E..cSSA..ll..VL..DKsG+VQWsKDGALTp-EVQpVlsLlpK.L.................	0	6	21	49
+9528	PF09696	Ctf8		Ctf8	Mistry J, Wood V	anon	Pfam-B_46199 (release 21.0)	Family	Ctf8 (chromosome transmissions fidelity 8) is a component of the Ctf18 RFC-like complex which is a DNA clamp loader involved in sister chromatid cohesion.	21.10	21.10	21.70	21.40	19.40	20.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.51	0.71	-4.33	31	267	2009-09-10 14:53:20	2007-05-21 11:57:48	5	5	235	0	194	259	0	116.80	29	75.80	CHANGED	pl.lpTPp......GhsllElQGslplPp......................ppshtssphGcLpa.............p.pptp+shLaVGppQRLhGplhKLspPLull++p.t...............................t.tpspspplcll-ll+hKl.lFKsRPhPl	.........................t.............thsllELQGplph.t..................................................ppshtsh.lGcLpa.......................pp.ppshLhlG.appLpGclh+Lp..+PluVlc+ppt..................................................t..ttpp.psphp...lssll+tKl.lF+sRPcPl...................................................................	0	64	107	165
+9529	PF09697	Porph_ging		Protein of unknown function (Porph_ging)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This family of proteins of unknown function is found in Porphyromonas gingivalis (Bacteroides gingivalis).	25.00	25.00	25.30	25.00	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.45	0.72	-3.84	44	420	2009-01-15 18:05:59	2007-05-21 14:53:50	5	2	119	0	136	412	109	59.90	41	22.25	CHANGED	Wcls.pEoKpIusYpChKATssh.................................................cthslpAWYTspIPlspGPtpahGLPGLILE	...................................................................................................................Wpl.t.s-.s.+p.I.tsY.pCpKAsspa............................................................................pGRpapAWaTs-IPl.sp.GPa+atG.LPGLIl...	0	37	118	136
+9530	PF09698	GSu_C4xC__C2xCH		Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This motif occurs from three to eight times in eight different proteins of Geobacter sulfurreducens. The final CXXCH motif matches the cytochrome c family haem-binding site signature, suggesting that the sequence may be involved in haem-binding.	21.10	21.10	21.30	21.10	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.60	0.72	-3.78	135	404	2012-10-01 23:37:15	2007-05-22 11:49:07	5	30	15	0	299	381	5	36.50	38	11.69	CHANGED	oCossYCHusuts........................s.tsss...Wsssssst........C..ssCH	.oCossYCHosGpu......................ssshssPs....Wsssssst........C..suCH	0	42	180	299
+9531	PF09699	Paired_CXXCH_1		Doubled CXXCH motif (Paired_CXXCH_1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents a domain of about 41 amino acids that contains, among other motifs, two copies of the motif CXXCH associated with haem binding. This domain is predicted to be a high molecular weight c-type cytochrome and is often found in multiple copies. Members are found mostly in species of Shewanella, Geobacter, and Vibrio.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.12	0.72	-4.44	178	1252	2012-10-01 23:37:15	2007-05-22 12:40:01	5	102	240	0	748	1592	142	43.00	29	19.96	CHANGED	HsPltpu.t..CssCH......sPHuS.s..pstlL..............ptssspLChsCHspttt	............................h..ts..p.....CssCH..........................sPH...uu..s.......ptthL............................ptstsp.lC.hpCHsp...s............	0	318	549	694
+9532	PF09700	Cas_Cmr3		CRISPR-associated protein (Cas_Cmr3)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This highly divergent family, found in at least ten different archaeal and bacterial species, is represented by TM1793 from Thermotoga maritima.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.17	0.70	-5.03	33	217	2012-10-01 21:23:39	2007-05-22 12:54:02	5	3	185	0	98	248	5	321.60	16	88.35	CHANGED	hhlpPhDslhFR-uRPFs...susps...stuhhhP.PpTlAGAlRsthhppsshph...sth.t.........................lplh.GPhlhc...........ptchhaP...tPhchhh.........hcppsshhphhtlc..........................ht.hhlsst...............tsthp.hsua.lshpslhp.aLpuch.ptp.........plhptt.............hhphEpRlGlulcspppss..........cEutLYpsp.hlRhp....................tshslulhlcsssssph...................tshhpLGGEsRhu......thch..........tth.sh.pt.ttshtpspphtl..hLhTPuhFspuh..hst..................................lsusul..s+sh....hlS.GWDh.tppcP+shp.......hh......sPsGoV...............aahchtpststtt.pttt........................tp.....hpp.GaGphlhsth	........................................................................................................................................hpPh-shhhtpspsFt.........ttt.........ht..s.h.P.spshhGhlpsh....hh.tt.t...................................................h.tlh.Gshhht..............ttphhhP...hPhshhh..................tttt...h...hp....................................h.......................tt.........t.a..hthpth......t..hhpst....t.....................ph.t................................ht.c.+htlslct..pppps...........c-..uhLaptp..hlc.ht..........................tthshshhlphttttt.........................tthhplGGEs+.hs.....tlph.................................th.p..t..htt..t........t...s.pthtl..hLlTPuh.h.p...p.sh.....hsth..............................................t....lhhhsh.....s+.h..................lu...Ga....ch....t....pp...p..s+sht..........................hh..........lssGoV...............a.hhc...h..t.t......................................t......pp.Gauhhh..............................................................	0	59	78	92
+9533	PF09701	Cas_Cmr5		CRISPR-associated protein (Cas_Cmr5)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This family, represented by TM1791.1 of Thermotoga maritima, is found in both archaeal and bacterial species.	20.40	20.40	20.70	21.10	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.51	0.71	-3.94	25	134	2009-01-15 18:05:59	2007-05-22 12:57:38	5	1	127	7	72	132	5	120.80	23	88.87	CHANGED	Tl-QppAptAappl...................pplppt................cphpccYtshs+cLPshIhpNGLsQsLAFlhuKucpptctt...........................LhccLspaLpppst...............sllctlhpt...-hppYhthTpEsLuhLsWl+RaApuhL	.............................hppphAphAhptl...................................................................pp..htp.................pphpccYpshs+phPshIhpsGLspslAFhhuKsppptpt......................................lhppltph.....lppptt......................................slhct.l.hpt...s..tpYhhhTpcsLthhsWlKRaupuh...........................................................................	1	47	59	67
+9534	PF09702	Cas_Csa5		CRISPR-associated protein (Cas_Csa5)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry represents a minor family of Cas proteins found in various species of Sulfolobus and Pyrococcus (all archaeal). It is found with two different CRISPR loci in Sulfolobus solfataricus.	21.70	21.70	22.30	22.60	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.23	0.72	-3.95	5	26	2009-01-15 18:05:59	2007-05-22 13:02:21	5	1	25	0	13	27	0	100.10	43	74.66	CHANGED	sFlYoEoPTYVDRIuNALSKEAVs+VLaEupRIlpoGl-uGEIcttss.........sGR+....YlsV..tEK-G.sYIllGtLPSDcDVEpFLc-VERDIYhARKVGALAMAhsN+	..h.FlhoEosolVDRhANALS+EsVs+sLaDs.Rllphul-pu.EIss..h.........pG+c....Yst.s.hppp-G..chhllGhLPosp-lE.FLchlccDlhhARKsGALAholss+..............................................	0	4	4	8
+9535	PF09703	Cas_Csa4		CRISPR-associated protein (Cas_Csa4)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR loci appear to be mobile elements with a wide host range. This entry represents a protein that tends to be found near CRISPR repeats. The species range for this species, so far, is exclusively archaeal. It is found so far in only four different species, and includes two tandem genes in Pyrococcus furiosus DSM 3638. CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	25.00	25.00	97.10	96.10	20.30	19.80	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.11	0.70	-5.48	6	13	2009-01-15 18:05:59	2007-05-22 13:06:21	5	1	12	0	10	13	0	355.20	23	95.95	CHANGED	lshhhTPGas.hhDThIhYGlVcsLstuGhssu.cVhshGpcYhIps-ssspt.hp...Eplc........huLhpshEEh...HhAhhscpsp..ss+lhpstDhssGssIsss..hplahctlstpLphlpcphctu++uscuc......thsTlsLsLhPshGKYh...lcphshpEspsh+VsphsYALAhlGFaY..YushlhhpcGcsplVplhshs....sh--LshlphLs.p-Lspcl.hsthschc.hlsp.hu.LYhLhhoEol....ElsocppFsllsYsh.EpssNsptlRsFtsl-lu+lh-FlhpLKthshYcshth.+hl-pL...........h+ts.ElhtpLh-slha-..s.tuhYoslRtl......p+ushsu...c..hlsslt-hlsph	.....hhTPGHshIsDsLIhaGlVctL.stuGthcu.pl..hG-cYhlps-hsstphh....pshc.........tLhphhcEh...+hshht.psp..tshlhpshshshstshss.....sah.....cplstpLpp.lccp..hcp.t++phcuc........thhTlhLsLtPshGKYh.............lcsas..lpp.statVCshCaALAhlGahY..hoshl..phcc.....Gpp....shVplhths....sh-clshhplLslpchtppl.hhhhsp.p..lsphhA.LYhLshuEol.....hsscpshsllsYsh..p+sGNs..Qthpuhtph-ls+L.h-FlhplKt..hYcs.ph.+hl-sL...........hcc....s.EsLtsLh-slhac..p.tshYpslRpl......c+ushstp......ht.l.phh....................	0	6	8	8
+9536	PF09704	Cas_Cas5d		CRISPR-associated protein (Cas_Cas5)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This small Cas family is represented by CT1134 of Chlorobium tepidum.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.51	0.70	-4.72	102	1346	2012-10-01 21:23:39	2007-05-22 13:35:06	5	3	1181	1	402	1115	32	210.50	18	87.80	CHANGED	slhl+lhG.shtsa.upsthtspRs....ohshPohSulhGlLsush.............uh.tt...................hpsslpaslct...........pptsplhp..sh.......pssp...................................t....tttttsshls.............pttYhhcAtahlshpsssp...........................hhp.hpctlccsthhhh..LGp+ps.s.stslp..................hps...pshh.......pshpphs.......................hthhh..........................................t..st..hpchss.......hps...phphuhhpl.	.......................lhhplhG.shAsa.spsthtttRt.....oaplPohSAlhGlLuAsh...................Ghtptt...................................hp..p.hphslpt.............................spp.sp.hhp....sh.........posp............................................hh.t......t..t...phhssh..lp..............................................ptpYhh.-A....h.....ahl.sl..tsssp...........................hhlp..lpc.sl..c..c..s..h..h...hh...LGp+pp..s..s.slt...............hps......psh....................pshp.ph.............................................................................................pt.s...............t...h..u.h................................................................................................................................................................................................................................................................................	0	160	289	348
+9538	PF09706	Cas_CXXC_CXXC		CRISPR-associated protein (Cas_CXXC_CXXC)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	CRISPR is a term for Clustered, Regularly Interspaced Short Palindromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This entry describes a conserved region of about 65 amino acids from an otherwise highly divergent protein found in a minority of CRISPR-associated protein regions. This region features two motifs of CXXC.	21.00	21.00	21.20	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.59	0.72	-3.80	10	84	2009-01-15 18:05:59	2007-05-22 14:03:33	5	2	83	0	35	86	4	64.70	28	12.16	CHANGED	cscsphsChsCGcRpspphKs.ht.h.cosh.PLhuS.ushtNaFWsspsssslCPlCpllhphsPhuhh	....................h.pctph.ChhCu...p..t..t.....hc...s...t.hshhtcss...........a.....s.sctpsahWsh.p.s.shslCslCpllatssPhGhh........	0	14	21	26
+9539	PF09707	Cas_Cas2CT1978		CRISPR-associated protein (Cas_Cas2CT1978)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a minor branch of the Cas2 family of CRISPR-associated protein which are found in IPR003799. Cas proteins are found adjacent to a characteristic short, palindromic repeat cluster termed CRISPR, a probable mobile DNA element.	21.80	21.80	22.10	26.80	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.74	0.72	-4.04	33	643	2009-01-15 18:05:59	2007-05-22 14:09:50	5	3	629	0	107	344	9	83.70	58	72.52	CHANGED	MhVllscslPs+LRGcLuhWhlElcuGVYVG.shSs+VR-hlWpplsch....hpc.GsuVMsassss.EpGashpThGcscRtsVDhDGlhL	........MlVlVsENVPPRLRGRLAlWLLEVRAGVYVG.csSpRlREMIWpQlsph.......sss.GNsVMAWATNo.EuGFEFpTaGcNRRhPVDlDGL+L...	0	28	75	92
+9541	PF09709	Cas_Csd1		CRISPR-associated protein (Cas_Csd1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins that tend to be found near CRISPR repeats. The species range, so far, is exclusively bacterial and mesophilic, although CRISPR loci are particularly common among the archaea and thermophilic bacteria. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins.	21.20	21.20	30.00	29.90	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-13.01	0.70	-6.22	36	393	2009-01-15 18:05:59	2007-05-22 14:22:25	5	3	343	0	123	375	18	525.50	25	96.60	CHANGED	LhchYpRhtppst............lsPhua.stcpls...ahlsLstpGshls....shcptcs+cth...h.lPpst...pRo.oult..sphLhD+hsYVLGs.s...........ptttcptpt.........apuFhphlpp.hsss...p-tslp...AlhpFLcp....s..htshh..............thpp..............................p.tss.lsF+l-.ussp...hlaccsslpphWtphhssp...ps.........ps.lCLVoGcps.slAchHPshh....tspusG..ApllSFNps.uFsSaG+..p.....pupNAPlShpuuhthssALsaLlp+pppp+............plGD.sssVFWAppss............hpsshts.hshh..........tcsss................psspplpthlpphhsGhtsp.sss.....scaalLGL.usNuuRlulRaacpsshuchhc+lppaac-hthhp.t...................hhpsPt.hslhpllhuss...........+s-s.lsP..sLuucLhpuIlsGp...aPpsLlpsslpRhR...upp..............phsh.+suhl+AsLhRph+hpppt........hshuLDpspsshuYLhGRLFAlhEplQcpAl...sG..lNATItDRaauuASssPsslF.hLhcttps.HluKLtpcp.Ghhh.h..-+hlsEIhstlss...sFPsshsLspQGpFslGYYpQRpshap	..................................................LhphYpph.ttst....................l.s.ua....spppht.....hhlslspcGphhp.........hp.....h..p...tcpth...............h.lPts......pRo..osht.........sphLhDphtYhhGh.t...................................pt..pttp..ttt.................apsahphhtp.hhp......ps......t...lp.....Alhpalpp......ts.hht...................phtt....................................thhss.l...hFplp.tttt................hlhpctshpph.atphhpsp........................pst.......tt.hChloGcps...sluch.Hsshh.......tspsss.Ap..llShNt..........s..uFs.h.G+..........p.........pstsuslutpsu.thpsALpaLlpppt.ph............................plGs.tshVhWupssp..............h..p.h.....h..shh........................t..p.............................pttpph....tphhp...p..h..h..pGh.....hp..s.........tph.alluL.uss..suRlul+aahphshsphhppltpaapc.hth.t...............................htt.s...sl..hphlhtss....................pscp...h.s.......tlhtplhpullsGp...hP...slhpthltRh+.......utt................p.hs.h.+.....s.th.l..pshLh.+phph.tt.................hshsLspp....p..p.shuYlhGRLhAlhE..plpptAh......................s...hpsTht-RahsuhuspPhpsashLhphhp...ahp+.l.p.p...t...........s.....h...........h.............cc.ls-lhstls................sa...s.p..phsLp..u.tFhlGYYpQ+pthh..........................	0	51	88	107
+9542	PF09710	Trep_dent_lipo		Treponema clustered lipoprotein (Trep_dent_lipo)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a family of six predicted lipoproteins from a region of about 20 tandemly arranged genes in the Treponema denticola genome. Two other neighbouring genes share the lipoprotein signal peptide region but do not show more extensive homology. The function of this locus is unknown.	24.70	24.70	24.80	37.10	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	394	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.40	0.70	-5.79	4	20	2009-01-15 18:05:59	2007-05-22 14:31:14	5	1	2	0	8	20	0	282.90	34	80.84	CHANGED	sKLKLIFILhLAVLLFSC.oKElKEtpphcscV.SshhhEsK.....Esph.SKsE.spaV..............poP..E.IK.LEpK....ctat.pL+plthELDch-.lh..sYcp.sthuIDpLspQK.........NlEhI...clc+DsE.hYCK.KtsspNGtpL.YplsYcWYshtphalshsY-LLpEpNhstIs-clIcpQVHGplhphcpD.cK-chIKlFEcY.Np..............Ttl+ppchtpYsh+lLDYVKGNFTNSGYDEYhVhFhp-................ssDsEl.D.......paIccVcCFlV-psKlIKsYhIsspuuhFhPs.hppssL.t.........lpsFGhpFSQGWlADFNQNGINEIY.ltahphtsstlhhlEF.DppFVpthlhsps.-lsuVDWaKKpI..........ll+DcotsscWhc-.YQWN-s.+palL	..sKLKLIFILlLAshLFSC.SKElKEpp.EcscVEossKhE.K.........psEh.uKt...Ehspch..............cos......EtIK.L.E-K....Ktat.plp.l.hpLDhh-.hh..th.....hshs.h...p...............hphh...ch.p-tc.h.hh.ph.....t.h.Yph.hp......h.p....................................................................................................hFh....................tsph.p.........lp.lthFlh.ttphhp.Y.l......h.....t...h...............t..h..shluDhNQNGhNEIa..............h..s.hh.hEa.tt.F....l....t..h.slDW.pphh...................................................................................................................................................	0	8	8	8
+9543	PF09711	Cas_Csn2		CRISPR-associated protein (Cas_Csn2)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	CRISPR loci appear to be mobile elements with a wide host range. This entry represents proteins found only in CRISPR-containing species, near other CRISPR-associated proteins (cas). The species range so far for these proteins is pathogenic bacteria only. Clusters of short DNA repeats with nonhomologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered, Regularly Interspaced Short Palindromic Repeats).	20.90	20.90	21.20	20.90	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.11	0.71	-4.61	5	132	2009-09-11 11:10:28	2007-05-22 15:11:46	5	1	132	12	11	105	1	185.20	44	84.50	CHANGED	lVKahYQYDEDSELKlFDcKhKSLKuSELMLVTDILGYDVNSuslLKLIHADLEsQFNEKPEVKSMIDKLsATITELIuaECLENELDLEYDEITILELIKALGVKIETQSDTIFEKhFEILQVYKYLoKKKLLVFVNSsAYLTKDElhpLpEYIsLoQhsVLFLEPR+l-GFsQYILDcDYFLIsEN	...............................................................llp.hYQYptpp-LKlF..Dtc.+sL.K.toELh.llTDlLGaDlNSsshLKLIauDLEsQ.....L.N-KPEVKSMI.-..KLsuT.IoE.L.Iu...a.E..h...LE..p.ELDLE.h.D.EITllELhKALGlKIE.Tp.S.D.T.lFE..Khh.E.IlQVa+YLoKKKLLlFlNssuYLTc-EltpLhEYIpLsplpVLFlE......s...R....c.......l.........s..h.s.Q.....YllDpDaaL..c.........................	1	2	6	9
+9544	PF09712	PHA_synth_III_E		Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents the PhaE subunit of the heterodimeric class (class III) of polymerase for poly(R)-hydroxyalkanoic acids (PHAs), carbon and energy storage polymers of many bacteria. The most common PHA is polyhydroxybutyrate but about 150 different constituent hydroxyalkanoic acids (HAs) have been identified in various species.	22.10	22.10	22.40	22.20	21.60	22.00	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.97	0.70	-5.01	10	111	2009-01-15 18:05:59	2007-05-22 15:24:40	5	1	108	0	41	130	21	237.60	22	79.03	CHANGED	sDahEhQRpYWsuWu-suR+uhu.........t.tupssssWpcul-.Whcthussusspspshh-chhcQupsaathu-phhpt..ttsttp..........LcQhtcpFuG.hp.....tssotpchsshWphPl-s.....aQphhSohpshssshhpsh........hpthppphsphLssPuLGhsREcQuQhQpLhRsth-YQpAhpcYssthsplu.cul-+htspLptshsSupsls..SsRALYDpWlcssEpuYu-hlto--YsplaGcLlNApMpL++thQphlDchhpuLshPTRpELcosp+RLpELRRcp+tLp+	..........................................................................................................t.....................................................................................................................................................hpt.h....t.t.............................t....t.h.t.a......tt..................ht...ht..s.......s.s.ht.h..............................p.h.ptt.t.hh.....p..PhhG.s+p..ptph.t.hhcs....ph.tt.ttY.t.htpsh.puhtphtpcl.ph.ppspplp..oh+thh-hWlpss-csatchhtocpFtcshGphlsuhhch....+tphpchh-phhcphshPTRuElDsltc+ltELcRcl+pl..p....................	0	13	26	35
+9545	PF09713	A_thal_3526		Plant protein 1589 of unknown function (A_thal_3526)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This plant-specific family of proteins is defined by an uncharacterised region 57 residues in length. It is found toward the N terminus of most proteins that contain it. Examples include at least several proteins from Arabidopsis thaliana and Oryza sativa. The function of the proteins are unknown.	25.00	25.00	25.00	25.50	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.70	0.72	-3.83	15	206	2009-01-15 18:05:59	2007-05-22 15:30:56	5	3	36	0	120	187	2	53.00	50	20.53	CHANGED	VQpLIE+ClphYMS+EEsspsLpcpAsIsPhhTps........................VWppLEKENtEFFcsYtp+	..............VQpLIE+CLphaMspcEslc.sLpp+.ApIcPshTph.........................................VWpcLEcENpEFF+AYhh.................	0	27	75	99
+9547	PF09715	Plasmod_dom_1		Plasmodium protein of unknown function (Plasmod_dom_1)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent an uncharacterised family consisting of a small number of hypothetical proteins of the malaria parasite Plasmodium falciparum (isolate 3D7).	21.30	21.30	32.20	32.20	20.80	19.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.20	0.72	-4.04	5	9	2009-01-15 18:05:59	2007-05-22 15:47:30	5	1	1	0	9	9	0	66.30	39	31.54	CHANGED	oFFKRAKLlL-sFDNIFIDKLIDuNIpNKuSsl+EDVh-NuLsLssAsI.hhAIPIaoYlsKRINFF	SFFKKhKLlhshhDsla.DhLIssslpstu....EhV..ssLuhhsushP.huhshhsYlspRINFh	0	9	9	9
+9548	PF09716	ETRAMP		Malarial early transcribed membrane protein (ETRAMP)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homologue from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.	25.00	25.00	25.50	25.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.90	0.72	-4.03	32	90	2009-01-15 18:05:59	2007-05-22 16:41:14	5	5	16	0	54	94	4	83.20	24	37.35	CHANGED	MKlsKl.hhhhshLLulpll.............................................sPsh.ssss.tspss.................................+thtphpsshp+K...hcppKhhllSoluoslAl..llusul.GhuhYpppKpp	..............................................MKlsph.hhhhhhlhh.hphh......................................................................ssh.spts.t.tppts........................................tslcphc.pslpcK...h+pcKhllloo..luoslsl..llussl.GlshYhp+Kp.s......	0	13	25	44
+9549	PF09717	CPW_WPC		Plasmodium falciparum domain of unknown function (CPW_WPC)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This group of sequences is defined by a domain of about 61 residues in length with six well-conserved cysteine residues and six well-conserved aromatic sites. The domain can be found in tandem repeats, and is known so far only in Plasmodium falciparum. It is named for motifs of CPxxW and (less well conserved) WPC. Its function is unknown.	21.10	21.10	22.50	21.90	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.83	0.72	-3.35	72	270	2009-01-15 18:05:59	2007-05-22 16:49:37	5	9	13	0	270	301	4	60.40	28	48.96	CHANGED	Cp.....cs.Ysp..CPtsWh...........tspst.....Chus..ssY....pGs..Cpphh.pFpp.hspppKppauppCplpWPChp	.......................ps.Ys.....t..CP..hsWh................hspsh............Chus...psY.................pGs..Cpp.....hh..shps..h..s.pppKpp.....apppCplpWPC...................	0	84	120	223
+9550	PF09718	Tape_meas_lam_C		Lambda phage tail tape-measure protein (Tape_meas_lam_C)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This represents a relatively well-conserved region near the C terminus of the tape measure protein of a lambda and related phage. The protein, which controls phage tail length, is typically about 1000 residues in length. Both low-complexity sequence and insertion/deletion events appear common in this family. Mutational studies suggest a ruler or template role in the determination of phage tail length. Similar behaviour is attributed to proteins from distantly related or unrelated families in other phage.	21.80	21.80	21.80	22.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.26	0.72	-4.07	62	1382	2009-01-15 18:05:59	2007-05-22 16:53:26	5	11	585	0	77	1312	114	76.70	38	9.36	CHANGED	pusWhsGs.ppuhtsah-sApssuup...spphhosAFsuhpsulssFlsTGKhsFcs...........assSlluDlu+lssptuhssslsu	.......................pGsWhsGl.ppGaupat-sA.sD....shuQ...scsssTpsFsGh....up....shAshlT...such...s...aRu...........F...T.pSVLu.hocIlh+tAhlshlt...............................	0	15	38	57
+9551	PF09719	C_GCAxxG_C_C		Putative redox-active protein (C_GCAxxG_C_C)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry represents a putative redox-active protein of about 140 residues, with four perfectly conserved Cys residues. It includes a CGAXXG motif. Most members are found within one or two loci of transporter or oxidoreductase genes. A member from Geobacter sulfurreducens, located in a molybdenum transporter operon, has a TAT (twin-arginine translocation) signal sequence for Sec-independent transport across the plasma membrane, a hallmark of bound prosthetic groups such as FeS clusters.	21.30	21.30	21.30	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.30	81	793	2009-01-15 18:05:59	2007-05-23 10:44:21	5	8	499	4	237	679	25	120.90	26	77.02	CHANGED	asCupulltuhs-phuhs.ss....sl+huuuFGuGhG...sGssCGAloGuhhslGh..................hhGcsp...............ttttppchhthsp-lhctF+....ccaG..uhpCcpLhtt..................tt..tpppCsplltpssc.hlt-hL	................................asCupulltsh....s....-ph...shsh..pp.....shchuuuF...u.uGhG..tht.ssCGAloGuhhslGh..............................hhGcsp.......................ttttptpshthsp..........-lt.p..p.Fc......................pc...hG.....ohhCppLhst............................tp..ttppCsphltpsschhtchl............................................	0	118	214	231
+9552	PF09720	Unstab_antitox	Stabl_TIGR02574; 	Putative addiction module component	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This entry defines several short bacterial proteins, typically about 75 amino acids long, which are always found as part of a pair (at least) of small genes. The other protein in the pair always belongs to a family of plasmid stabilisation proteins (IPR007712). It is likely that this protein and its partner comprise some form of addiction module - a pair of genes consisting of a stable toxin and an unstable antitoxin which mediate programmed cell death - although these gene-pairs are usually found on the bacterial main chromosome.	22.40	22.40	22.40	22.40	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.32	0.72	-4.28	83	291	2009-01-15 18:05:59	2007-05-23 14:36:35	5	3	140	0	122	319	88	54.20	24	70.64	CHANGED	pLsspERlpLl-pLhcSLsp...s.ps..c.lsphatpElccRhpthcsGpspslsh--lh	...........................pLs.pERhtLs-pLh.cSLst....s.ps..........p.lsphatpEhccRhpphcsGpsp.slsh--lh.......................	0	43	74	117
+9553	PF09721	Exosortase_EpsH		Transmembrane exosortase (Exosortase_EpsH)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Members of this family are designated exosortase, analogous to sortase in cell wall sorting mediated by LPXTG domains in Gram-positive bacteria. The phylogenetic distribution of the proteins in this entry is nearly perfectly correlated with the distribution of the proteins having the PEP-CTERM anchor motif, IPR013424. Members of this entry are integral membrane proteins with eight predicted transmembrane helices in common. Some members of this family have long trailing sequences past the region described by this model. This model does not include the region of the first predicted transmembrane region. The best characterised member is EpsH of Methylobacillus sp. 12S, where it is part of a locus associated with biosynthesis of the exopolysaccharide methanol-an.	25.30	25.30	25.30	25.40	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.97	0.70	-5.18	102	524	2009-01-15 18:05:59	2007-05-23 14:54:15	5	4	392	0	259	557	185	236.50	17	69.36	CHANGED	hlhshhlhh....ah..h.t.........hhttW..hp.s.....tphsHuhllhslsha.lhatpp.t.h...tt...ts..h....ulhhlhhuh..hhalhuph.......sth.hhhtthuhshhlhuhhhhhh...............Ghphhp............th......hhPlh.hllhhlPhs..thl......hs.hs.sLpthsuphsshhLphhGhslhh......c..........Gshl.....hlsstp....lpVspACSGlchlhshhsluslhshh..hptshhp.+hhhlhsul.slsllsNhl....Rlhhlsl.ls...hhs.........................phu..tshhHthhGhlhFssshhhlh.hlsthhtph	.........................................................................hh................................h........................h.hh..h.hh...hhh.......h.....................................shhhhhhhh.....hh.hhht.................................h..hsh.h.hhh..hshhhhhh...........................Ghthht................................hh.........hhslh.hhh.hh..l.Ph........h............h...h.h.....sLpths...uthss..hl..l.p..hh..G.....h..s...shh.......p................................Gshl.....hl.s.stp.......lpVst..uCoGlph.lhhhhulshhhh.h........h.tshhc...+l...h.h....hhh.ul....slsh....hsNhl....Rlhhlsh..ls......hhs...............................phh....hshh..H.p.h.h..G..hlhahhhh.hhlh.hhh......hh......................................	0	88	205	245
+9554	PF09722	DUF2384	CHP2293; 	Protein of unknown function (DUF2384)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. The function is unknown.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.39	0.72	-4.11	120	1010	2009-01-15 18:05:59	2007-05-23 17:01:51	5	9	668	0	338	835	106	54.10	24	37.91	CHANGED	hppspsla.Gsp..........ptAppWLp.pPshu..LsGppPl-llp.o..ttGhptVtphLspl.ctGl	...............................................h...h..lh.sst..........ptA.tpWlp..pPstu..LsGppPl-llt..s....suhhtVhphLsthctG...................	0	84	192	261
+9555	PF09723	Zn-ribbon_8	CxxC_CxxC_SSSS;	Zinc ribbon domain	TIGRFAMs, Coggill P	anon	TIGRFAMs	Domain	This entry represents a region of about 41 amino acids found in a number of small proteins in a wide range of bacteria. The region usually begins with the initiator Met and contains two CxxC motifs separated by 17 amino acids. One protein in this entry has been noted as a putative regulatory protein, designated FmdB. Most proteins in this entry have a C-terminal region containing highly degenerate sequence.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.56	0.72	-4.00	182	1432	2012-10-03 10:42:43	2007-05-23 17:08:51	5	3	985	0	622	1298	568	41.50	36	43.22	CHANGED	MPlY-YpCp..pC..GppFEhlpphu-..ss.ssCPpCuu..p..hp+hlS	...MPhYcYp.......Cp..sC..GppF-h.l.p.p...hu-......sshssCP..pCuu..phc+lh...................	0	254	465	555
+9556	PF09724	DUF2036		Uncharacterized conserved protein (DUF2036)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG0798)	Family	This family of proteins includes members ranging in size from approximately 300 to 460 residues. There are a number of well-conserved domains along the length.	20.50	20.50	21.30	20.60	19.10	19.80	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.01	0.70	-5.29	22	306	2009-09-11 06:41:13	2007-06-15 09:23:13	4	5	268	0	216	306	2	281.80	22	80.09	CHANGED	sYpLLplsscllcplc......pu....p..sLtl+Gt..................s-cu..VLCocs+TaslKthcpSNolLLh.thh.s..................................p..tst....phphhshspphhElpp..h.psphcplcp..lthshasG..cstt..ch.t.............ashcpLlsssQsScpEhpptLpp.lsuhpl-.GthplLs.cahh+hLshllthlsspuhsh..s....clshpsshpslt.s...........hsppllcsslpha....upp.s-..................hapLctpplsphhuhtlLpphh.........phplc-...........Fh.pWppplP.......shshchchLcGhsllp...........pstsp...plphls.psL.Ppshp-RFppLFph+p.cWsh--lpPaIc	...............................................................................................hpLlcL.ssplhp.lp......................ps.........p.........pLhl+ut.........................................................s.-ps......VLCops.cTapl+tspp..SNslllh..h..stt................................................................t...............thphhuhh.pphhElpp.......h....tsphp...tlt.h..h..s.apu..p........ptt.p.t......................................................hshppLhpph.sSptEh.pthp.p...htu...h.............h......p....G......h................hp.h.lp.ph.hphl..phlht.h.t.ps...hth..p.....................p.hshpphhptlt....................................................spthhpth.l.p.ha........sp...t................................................................t.........hhplptptl...sphhu..h.Lpth......................ththp-..........................Fht.Wppt.lPt...............th.sp.hp....Lp.Ghhh................................................t.st.t..hl.hh..ppL.s..p.....ttRht.LFphp..pWp.t-htPal...................................................................	0	74	121	178
+9557	PF09725	Fra10Ac1		Folate-sensitive fragile site protein Fra10Ac1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1297)	Family	This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved protein, of unknown function that is nuclear and highly expressed in brain [1].	20.90	20.90	21.50	26.10	19.20	18.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.75	0.71	-4.01	11	188	2009-01-15 18:05:59	2007-06-15 10:13:15	4	8	151	0	128	192	2	114.90	55	41.83	CHANGED	+TDhDlLKccH+Fl+D----sc.........sWtcpLA+KYY-KLaKEYsIhDLS+Y......+csKl....................GhRWRTEsEVlsGKGphhCGs++C.....................................................pcspsLcoaElsFsYhEpGccKsuLVKlRlC.cCuhKLNY	.......................................+TDhDll+EsHRFlhs-E..-.-...-.......................oWEpRLAK+YYDKLFKEYCIADLS+.Y......K-sKh....................GhRWRsEcEVlsGKGQFhCGN++.C..........................................................................................................s.c..c-sL+SaEVNFuYhE.cGEp+sALVKlRLC.cCohKLNa....................................	0	58	75	104
+9558	PF09726	Macoilin		Transmembrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1821)	Family	This entry is a highly conserved protein present in eukaryotes.	32.00	32.00	32.40	32.70	31.60	31.20	hmmbuild  -o /dev/null HMM SEED	697	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.29	0.70	-6.25	5	207	2009-01-15 18:05:59	2007-06-15 10:14:40	4	6	88	0	126	181	0	441.60	33	90.48	CHANGED	KRRNs-CGK..RRPlKRs.KhAEGlsuSTFLYIKFLllWshVLLADFlLEFRFEYLWPFWLLIRSVYDSFKYQGLAFSVFFVCIAlTSDlICLLFIPlQWLFFAASTYVWVQYVWHTDKGICLPTVSLWILFVYIEAAIRaKDLKN.PH.lDLCRPFAAHCIGYPVVTLGFGFKSYVSYRhRLRKQREVQKEN-FYMQLLQQALPKE..s+sLpss-KEsoEsoocuhToscsllsspsstssssssKlSs.shsplthp-pupcptp...sssppp+slupsNs...pspsl.......suslQ-lEhhps+oNuS+hoss.hsGsspshsh+cc......opuSSssptossSKsSsosptstts.uNSSP+SHsss.............................................................................................................NGSVsSSSsscN.........-cKpKpuupssutth..c..h...ssscsVcsshssNp...lSoPsAls.....................RLEsDIKKL+AELssuRQsEsELRsQIS.LoStERShKS-LsQL+KENDhLQTKlpuhVSuKQKDKQolQolEKRLKuEp-uRsslEKQLsEEKKRKKpEE-TAARAsA.AtsoRt.EsuESLKp+K+DLEsEIcKLpp-lKlKEEppcsLEKcs....QEl+KY......+E.SpK-TEVLMSALuAMQDKNppLENSLSAETRlKLDLFSALGDsKRQLEIApGuIapREpEIlDLKuKIA-llAVMPs.shu...SplpssTPHYSupFL-ssPuutsosuSsY.sL	..........................................................................................................................................................................................................................................................hh.hDhhh.hRhEhhaPhWhhhtshhpohphp............sl.......h.........hshhFhhhshh.shhChhhlPhphlhhhuoshVhhthhhp..s...........ptG.......................................husH.lGas.h.hsh.hp.hht...hh.phphtltttN..hhp.h.puLP..................................................................................................................................................................................................t...............t..........t.................................................................................................................tt...t...t....t............................................................................................................................................tts.........s.s.s.....p................ppt.ttt................................tt...t.........t.t...........................................................................................p...Lct-lcc..h+s-lpt.+p.Ep-h+tp..............h.s.tth..t.+.phtthptcs-........lpp..........+htph.p.+pt-+.shtthE++.......l......ttEtct+..........h-tpL.pp+pt+h...........tt.........t.....................................................ptsp.......h..+tc..pph-...t-hpplphchp.t-pth..h..ch......................................ttht.............................pc.......t.-.-hLhtsLtshp-Ks.pLEpsLuuEsRlK.-LFpsLGts++phc..t..................................................................................................................................................................................	0	47	58	97
+9559	PF09727	CortBP2		Cortactin-binding protein-2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1103)	Family	This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans.  The human protein has six associated ankyrin repeat domains Pfam:PF00023 towards the C-terminus which act as protein-protein interaction domains [1].	25.00	25.00	27.50	27.00	22.90	23.30	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.28	0.71	-4.80	8	414	2009-01-15 18:05:59	2007-06-15 10:15:04	4	12	99	0	190	349	0	128.90	39	16.96	CHANGED	suc+Epcs-sLSKc-LhhLLSlMEGELQARD-VIchLKA-Rp-lhl.EApYGphs.pcPhtALQRDuhtuuucsppccl...YpsPlupL-+lht+pKcoQcRMhsQLlsAE+pp++hlhcL-t-+ct+hcahppuD-hhshLEpctp..Lp..LE.EKupppptEpE+cKhss+Lc-EhsKhKShsLMLVcEppph	..................................phsp.-Lh.LhuhhEGElpAR..-.VIthL.+..........sp+hc..l..Et.YG..h.p..........p......csh.uLpRDh.....................h..t.......t....t......................t.p..sl....................hppPhs.Lchl.tpp+ph.cRh.tQLhhuEppp+p.......................................................p..p...lE.E+...tthEpEppKh.tpLc-Ehs...+.KphshhLltEpp......................	0	20	35	91
+9560	PF09728	Taxilin		Myosin-like coiled-coil protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1850)	Family	Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells [1]. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localises to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription [2].	27.40	27.40	27.80	27.40	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.12	0.70	-5.34	18	400	2009-01-15 18:05:59	2007-06-15 10:17:26	4	7	207	0	247	384	2	263.30	35	60.93	CHANGED	+chsKtsp.LhpsLsphss.t-KlptlhK+hsEhlp-p+php+phphhpK+hptlp+EK-plpsEps...Kshhs+sKLEsLCRELQ+cN.+pLK...........EEshpptcEE-c+RpEhsp+FQssLpDIQsph-ppsscspc...Lpc-NpcLscKlKpll-QYE...........lREpph-+lhKp+-LphQLs-AKLpptppthppppp+pcppp-hhhpph.....plpphpcpEppL+.........................pQLslYs-KFc-FQsoLsKSN-lFsTFKpEMEKMoKKhK+LEKEstsa+s+aEpsNpsll-MsEE+ph.......pp+chcphpp+lp+LEpLCRuLQsER	..............................................................................t...t+....l.p.l.s....p....hps....p+lt....hl.h.K+hs-Llp-h+p.....p+p.hp.hhp..K+ttpl.p-+cp........l.puEhs....................+sl...hs+sKLEsLCRELQ+cN.+pl..K...........................-Eshph....scc-ccpRpEh...ss+F...pssLp................-Ipsph-..ppspc...shc..............hp-..N.t........Lt.....pKLKplh-QY-...........................lR.EpHhcc..lh.+...p+-L.p.pLhpAKlpptpph.hcptpp+ppp.pp......................................psp.hpppEspL+....................................................t.QLslYs-KFc.p...........hp.....sTLsKSNElFtoF+pEM-cMoKKhK+LEKEshhh+p+aEpsNt.......sllphhEE+ph...........................ppcchcthphchp+LEpLCRthQtpt....................................................	0	73	114	174
+9561	PF09729	Gti1_Pac2		Gti1/Pac2 family	COGs, Finn RD, Bateman A	anon	COGs (COG5037)	Family	In S. pombe the gti1 protein promotes the onset of gluconate uptake upon glucose starvation [1]. In S. pombe the Pac2 protein controls the onset of sexual development, by inhibiting the expression of ste11, in a pathway that is independent of the cAMP cascade [2].	20.40	20.40	22.00	20.80	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.12	0.71	-4.38	32	332	2009-01-15 18:05:59	2007-06-15 15:36:41	4	3	138	0	260	349	0	134.00	35	33.49	CHANGED	Ta.pGalcospDALllhcAshp.......GhLs..plsRR.p-cERs.hIpSGsVFVapEppoGhKRWTDGhsWSPSRl..GpFLlYRELsKpp...........................t...tttt...ps...tt.tp.s.h..........................................................................................................................................................pshtaK.sG...LlKKThSlpsp.......................tspphHlISYYsh	...........................................oa.GalpostDAlllhcA.sh............GhL...pltRR.p-pERt.hIpSGsVFVa..pE.............p.........p..u..........Gh+RWTDGhsWSsS.Rl...G.s.FLhYREh-tth..............................................................................................................................................................................................................................................................................................t...h.h+.sG..LhKpohSlphp..................phHllSYYt.h...........................................................................................................................................	1	105	173	236
+9562	PF09730	BicD		Microtubule-associated protein Bicaudal-D	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG0999)	Family	BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta Pfam:PF05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells [1].	26.00	26.00	26.30	27.10	25.40	25.90	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.61	0.70	-13.47	0.70	-6.18	11	255	2009-01-15 18:05:59	2007-06-19 14:23:25	4	5	95	0	150	256	0	528.20	44	84.39	CHANGED	upuhSsp++sAtDGEopEEoLLQESAuKEuhYtt+lLELQsELKQsRshlsNspuENERLsslsp-l+-s.................spslElpRsRhR-ElKEYKhREsRLLQDYoELEEENISLQKQVSsL+psQVEFEGLKHEI+RLEEEsElLNSQLE-AhRLK-IAE+QLEEALEoLKsEREQKssLR+ELspahshssh..hushplpl-tl..phpc-.ptsspss...........sDs-ch.sut.pss..ht.................phtsstpuElh..sPssu.....VsDLhSELplSElQKLKQQLhQhEREKssLhusLpEsQpQLcpupsslsEpp-+VspLTpplsAl+p.............................ttKctpss.-ppcspsspcs...st.aElDhpu.ElLpCKh+sAlsEhscL....+pELKsL+scapphpp..php--+s+hcs-lQsLscclpphE+su+pc.tc..........................chucLEpElpthsclAsEopGsLssAQDELVsFSEELApLYHHVChsNNETPsRVhLDaY+cuthhtt.t......st..scth.sshh.phhh.........tEs.t...t.....................spuPussu.osshSPs............tDhR..p-PhNIhNLlAlIRDQIKHLQpAVDRohpLuRQRsA....utcLushsD+DpEuhhEEILKLKSLLSTKREQIATLRsVLKANKQ......TAElALuNLKSKYEsEKuMVoETMhKLRNELKuLKEDAATFSSLRAMFAoRCDEYVTQLDEMQRQLAAAEDEKKTLNSLLRMAIQQKLALTQRLEDLEh	........................................p..o.p+hsstsG.ppE-sLlpEoAs+Et.h.tplh-hps-l+p...+t.htpspsEt-Rh.t..pchtc..................pp.hEhpRhph...+s-l+EhKhREsRLLpDYoELEEENIoLQK.VSsL+ps.......Q......VEaE....GlKHEl+RhpEEs.hLpuQlE-hhcLKcIuE+QLEEALEsLpsEREpK.sL+KELsphhshps........s..phth..sl...pth.....tpp..........p...........s-.t...tsh.t............................t...pst.h...P........hsDLhSElplsElpKLcpQL.Qh.E.pEKs.LhtsL...............p-sQppLcpspstLp..p..pclttLs.t.p.lpuhpt.................................t.p...ts.....-ttpttsttpp................c...L...ts+hp.suhs-hhpL....ptclcsL+tphpt..t...pht-.pp..s..........phcschp.hppplt.h...Ect.p.p.tt...........................thtphcp-LpthsphAsEspspLssAQ-ELlshSEELApLYHHVChsN...sET.PsR.V..hLDah+psps.htt.........................p.pt..h...s.sh...t.h..................................t........................ptt.p.s.p....s...ush.......................tD.p...p-sh.....slhsh.shlpDQI+H.Lpt.AV-+ohplu+p+hs........s.phssh.cc-tEth.Epll.KLKSLLSTKREQIsTLRsVLKuNKQ......TAE..lALuNLKsKYEsEKshVoETMhKLRNELKsLKEDAATFSSLRAMFAs..RC-EYlTQ............lDEhQRQLsAAE-.......EKKTLNpLLRhAIQQKLALTQRLEpLEh......................................................................................	0	43	60	108
+9563	PF09731	Mitofilin		Mitochondrial inner membrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1854)	Family	Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex [1]. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain.  In addition, it has three centrally located coiled coil domains [2].	27.40	27.40	27.50	27.80	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	582	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.81	0.70	-5.86	33	516	2009-01-15 18:05:59	2007-06-19 14:34:14	4	7	348	0	280	469	33	425.10	19	80.05	CHANGED	pssht+...hlhhhsLhsslsaGGslhhuphs-cFp-hhpct.lPhu......Ecllphh-pts.......................htt...phhpth.t...............................................sshspcstsspppssshttpss....................................t.pphtpshcthtpphlppstpthttst..........p.hpttsp.h..........................................................................................t......................h.tht.hssssstl..pplhshhscllsslsspsh...tschsshlscsppplsplspclsclppphcpclppplcppppc.hpphspphhtphctt.t..p.ppphppchppccpclccphcpcLcpcLcppppshpp+lpstlt.tplEhp+pFpc.lcc+lppER...........sGRLupLscLpup.lpsLEphstu.......hspshspscpsppLthulpulcusLcsuss.........pPlppclssLpch............................usc.............Dpllssulsulsstuhpc...GlhopspLhsRF.ppltsclR+sSLl..PssAGlhuHhsShlhStllFc.Kp....s.........supDl-olLuRscphLccG-LDtAsc-hss.L+G.Wu+...........cLApDWls-uR+pLElcphlcllpu-up	..........................................................................................................................................................................................................................t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t........................th.......t......................h.th..t..th.t.t..t...p....................t.t...ltt...................t.........t.t...............................t...p....tt.h............t.tt.h.pt.php......httttt..........tt.htp........t.t...........tt.h...t..pp......................tthh.pl.tph.sp.l................ptlpp....hhtt.................hs.......pt..s.phptlhhuspu..l.ptslppu......................hshtttlpslpt..........................................ssp.........s.hht......shltuls......uhpt...Gl.o.tpLhs+........F..tltp....hpps.uhl....tp.....sulhthhhuhl...Sh.lhhp...tt................................s..............ps.s....s..sllscsphhlp.pGcLc.Ahc.hsp.LpG..u+............tlu...p...-WlppsRhhl-spphhphl.t...............................................................................................................................................................................................	0	93	156	236
+9564	PF09732	CactinC_cactus	Cactin; 	Cactus-binding C-terminus of cactin protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2370)	Domain	CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo [1]. Most members of the family also have a Cactin_mid domain Pfam:PF10312 further upstream.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.77	0.71	-4.53	19	306	2009-01-15 18:05:59	2007-06-19 14:37:51	4	10	240	0	225	312	5	124.40	58	22.10	CHANGED	hscchcs...+KP+aFNRV+oGa-WNKYNpTHYD.h-NPPPKhVQGYKFNIFYP-L...hspsp..sPpYplps..........sts.ss-hsll+FpuG.....................PPYcDIAF+IVs+E...W-asp+t...GF+ssFcp..............G.lLpLaFsF..........K+hpYRR	.............................Wt-KYRPRKPRYFNRV+TGaEWNKYNQTHYD.hDN.PPPKlVQGYKFNIFYPDL...IDKsp..sPpYplpp......................sss..scDhsllRFpAG.....................PPYEDIAF+IVs+E...W-YStK+...GF+s.p.F.c.p.G..Ihp..LaFpFK+hhYR+........................................	1	87	133	186
+9565	PF09733	VEFS-Box		VEFS-Box of polycomb protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2350)	Family	The VEFS-Box (VRN2-EMF2-FIS2-Su(z)12) box is the C-terminal region of these proteins, characterised by an acidic cluster and a tryptophan/methionine-rich sequence, the acidic-W/M domain [1]. Some of these sequences are associated with a zinc-finger domain about 100 residues towards the N-terminus. This protein is one of the polycomb cluster of proteins which control HOX gene transcription as it functions in heterochromatin-mediated repression [2].	21.10	21.10	22.40	21.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.71	0.71	-4.53	11	298	2009-01-15 18:05:59	2007-06-19 15:00:15	4	4	186	0	137	263	2	114.50	39	22.98	CHANGED	tcclsuEpscsRshhh.h+pRpFaHScpsQPhphcpl.SDpDSEDEsD..c-hhchc-pphL--FsDVsc.sEKclM+LWN.FV+KQpllADuHlPWACEuFs+hHGp-Llps.sLhhsap......lahIcLasaGLlsucohspssphL	...................................................h..pp.h.........p.DS-sE.D..st.hhp.cp..hp.lp-FsDVsc.sEKElM+hWNha....V...h..K....p......s....h.....luDsp...lPhACphFlp.h...+GpcLlc+..s...LhRsFh......LHhssLa..DauLlsshsl.pssph...............................	0	42	73	107
+9566	PF09734	Tau95		RNA polymerase III transcription factor (TF)IIIC subunit	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2473)	Family	TFIIIC1 is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents the tau 95 subunit which holds a key position in TFIIIC, exerting both upstream and downstream influence on the TFIIIC-DNA complex by rendering the complex more stable. Once bound to tDNA-intragenic promoter elements, TFIIIC directs the assembly of TFIIIB on the DNA, which in turn recruits the RNA polymerase III (pol III) and activates multiple rounds of transcription.	27.70	27.70	27.90	28.10	26.60	27.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.23	0.70	-5.10	52	385	2009-01-15 18:05:59	2007-06-19 15:02:08	4	9	291	0	250	378	2	276.50	25	54.86	CHANGED	clsslEhPthV....psls+..................ulpslGG.ptlsp.....................slpstptp............................................................................................................................................lcLph.....p................spDsh..s+Pl..husp.....p.ssslLL+lsh...++stptpp....t................................................................hpschlGhlspsapFc...shuDFpahs......s..htp.........chppphhsh................pthp.hp.p.s..............................................................................................................................................................................................................................................hpl.......hPP....................................................................shFSphch.PasYt..................Ycpsstspt......................................................................................................................................................................................ttsp.t..........hsspppttphththhshs.hs.lPsp........................th.t.tthp.h.pptlphlcpLF-cRPlWs+psLh..splsp........pphtlK...............pslshluYhapsGPWRpshl+aGaDPRpcsp.thYQol.FR	...........................................................................................................................................................hhslchPhhl....ps.sp..................hltshGG.ttlpp..................................................hhtt.t..............................................................................................................................tlpLhh..p.....................spssh....s+Ph...hupp.......h.spsll..L+lph...+ppt...t......................................................................................................................................thphchlGhlsphapFp.................shsDFpahs................tp....phttphhth..................................h..h.t..t.........t..........................................................................................................................................................................................................................................h.h.....lPP..............................................................................................................................................................................................shFophsh.Phpah..................ac.ps..p...........................................................................................................................................................................................tt...........................h.h..thpp..tt........h.h.h...............s.hPpp......................................thp.h...p.ph..t.lp..p..LF-.....pRPlWo+pulhspls.............p.ptl..K.......................................................hhlshluYhhh.s.GPWRphhl+aGaDPR...p...ss.ps+hYQsl.FR................................................................................................................................	0	91	143	211
+9567	PF09735	Nckap1		Membrane-associated apoptosis protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1917)	Family	Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease [1]. It is involved in the regulation of actin polymerisation in the brain as part of a WAVE2 signalling complex [2].	20.10	20.10	20.10	20.70	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	1117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.88	0.70	-13.74	0.70	-7.09	8	304	2009-01-15 18:05:59	2007-06-19 15:03:46	4	9	127	1	181	296	1	741.10	36	92.42	CHANGED	spQpKlAEKLsILN-RG.GhLsRlYNIKKsCuDsKs+PsFLs-KshEsulKaIl+KFPslDs+ss..pLsslpcppsEIl+uLu.YYaoFVDlhEF+Dplh-LLsTlDusQlahDIslNaDlT+uYLDLlVTaVolhlLLSRlEDRKslLGlYNtAHEMpHGpSDsuF.sRLGQMIl-YDpPLKKLpE-FsPHo+tlosALpSLphlahRRNpou-pWRssQlLSLlusP.uslLssupo-ThACEYLSl-sh-RWIlhGallCHspL.ssssl.clWplALQsuLsloLFRDE.............................slhlHcshpshlpuhKGYuKRluD......................l+Es+EpAlupuuslH+ERRpaLRsAl+ELsLlLsDQPGLLGPKhLhVFhALuhARDEVlWLlRHsspss..pp+s+o...sEDhsDspIuELLFhMEcLRuLVRKYhuVlQRYalQYLSuaDAlsLspllQslulCsEDESlILoSF....lspLsSLssKQVEssEhF..DFouLRLDWFRLQAaTSsu+SulpLpcpc-.........LuchMNshVFHoKhVDpL-EhLsEsSDLShaCFYs+hhEchFtpsLEtP.upsRYsIAFPLlCuHFspCsH-hCPEE+s+Isc+uLuhsNpFLEEhAKpscslIsplCuE..ptsLupQLLPcHsA.+hloputscKspt..sps+KG.ts-hptPGtESaRKsRpslTshDKLphsLTELChulNas.slsVaEHsFsPREYLsspLEs+Fs+ulVuMstY.s.ssp-lsRPSElLuul+AYMollQolEpalulDloRlhpslLLQQT............QPtD.SpGcsTIsslYTNWYL-sLLRcsSsGsIVauPshpAFlShssE.thsFpAEEaSDlsELRALuELlGPYGhKhLsEpLMWHluSQVsELKKLVspN+DlLhtlRosFcKP-pMt..ull+pLs.............ssDsVLpRMhIIG.ILoFRsLhQEALccVLcp+lPFLhSsIcslp-plP.sssDhKshhpltElASAAGlsCclDPuLVsAltupKuc...spE.-acsuCLLLVFVAVSlPpLAtsssStYssph-GasNNlHCLA+AIsslsuA...............................LFol.tpssIEo+hKEFLsLASSSLLclGpEoDKsp......l+sREolhLLLD.lVpcSPaLThDhLESCFPYsLLRNAY+pVYcpsh	......................................................................................................................................................................................t...p...thh...s.h.........th..h.......t.t.t.hht.ht.ah..hhD.hh.hp..-thhphl.thts.......h.h..t.s..hh..ahpLhh.hh...th.hh.tp........c.+hlhthashha....h.ptt.-..th..+...................hsphh..h.p.....Ph+.hh.pch.......ht.......h....t....hl.uh..hh....t.p...p.h+t.thhs.ht......hh.ss.t...h...........h.....hh..h.t.h.pWhhh......shhh..t.h..t.................p..........h....hh..sLpts.hl.lh+-p..........................................................................hh.hHp..p..hh.s...h...h......sK..chtc...................................................lp....-.hp.sh..pss.hHtp...+R.hl.+.tltph..hht...cpPsLLuPp.....h......hh.h.uLsh.psEl.WhhpH.t......................t...........-..-....pls.Ll.hhtplpthltca..hhp.t.....Yhl..................palst.ss..lp.hht.s.........th.h..s.....-.shhh.psh....hp.ht..tls...p...........pp....................phpshRh.cWhpl...hhho.spsshtl.tc..p.......................lhp.hs.hh.aophl.Dth.p.L.cpusL.ph.hh.......aa..p..hp...t.Ft.....s.h..s..s..pa.hsa.hlsspF..psh.p...hs.PE.E................h.t...ltpculthsp.hl-phhtthpshl....lssc.....hthttp.LhPppsA...h...tt...th...............tt.....h....h.PG.E.Sh..csp...lp.h-thh.tLspLs.shs.h.sh.Vh.pashh.pEYhpppl..pht...c.lh.hh..............h....h.........s.tpl..........+PS.l.s.lptahshlp.htpalthDhophhppsLLpps.............................p.h-.tpst.ohsthhspWY.-sll+psS.......sstlhh....psF......hsh..............sa.s.-paoDhpEhpuLsclhGsYGhchLsctLh.Hhss.l.plcphlh..pNh-hL..th..tsshpps-.ht....t.h.p.l...............sh-sllphhh..hG.hlsF+thht-uh.tlhp.phPhlhu.ltsh.p.hs....s.h.p.........h.p.husssGl...sc.h.Dsths.sl.t.hst..........................t..hshhLh...al.hsuh.h.s.......o..ap.thtuatNNhHChsh...s...l.tl.su................................h.ph...........pt..s..hp..pth.....p..Flhhuu..lLp.....pp.p...p............................h.p..........lhhc.hhp.s.hls.s.hE.hhPashhpt....h....h.......................................	0	66	98	139
+9568	PF09736	Bud13	DUF2050; 	Pre-mRNA-splicing factor of RES complex	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2654)	Family	This entry is characterised by proteins with alternating conserved and low-complexity regions. Bud13 together with Snu17p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex. called The RES complex, pre-mRNA retention and splicing complex. Subunits of this complex are not essential for viability of yeasts but they are required for efficient splicing in vitro and in vivo. Furthermore, inactivation of this complex causes pre-mRNA leakage from the nucleus. Bud13 contains a unique, phylogenetically conserved C-terminal region of unknown function [1].	20.60	20.60	22.00	21.10	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.38	0.71	-3.93	44	337	2009-01-15 18:05:59	2007-06-19 15:04:41	4	3	291	0	240	323	0	136.80	36	33.20	CHANGED	-TlaR.Dp.oG+hI.shcppppcpcpcp........................pccpcccpp.ttphspG.lQtpppcpphpchpcttptsh....sch.pDp-hsp.h+pppRhsDPhspa......hppccppss..............thht+stY.............pGssss.NRFsItPGaRWDGVDRSNGFEpchFptpsc	..................................................................................................................cTlaRDt.sG++h..s.h.p.cc.t.ctccpt..........................pcptccc...ph.htphs+G.sQpcppppphcchtcttptPh....ARhh-Dp-h.s.p.L+pppRhsDPMspa.............lpcpctpts................................tptht+stY..............pGssPP.NRasIhPGaRWDGVDRSNGFEpchFtths.t..........................	0	82	130	197
+9569	PF09737	Det1		De-etiolated protein 1 Det1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2558)	Family	This is the C-terminal conserved 400 residues of Det1 proteins of approximately 550 amino acids [1].  Det1 (de-etiolated-1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian Det1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 Associated 1), and a member of the UBE2E group of canonical ubiquitin conjugating enzymes and modulates Cul4A function [2].	25.00	25.00	28.70	26.30	18.00	24.20	hmmbuild  -o /dev/null HMM SEED	407	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.36	0.70	-5.71	8	179	2009-01-15 18:05:59	2007-06-19 15:06:35	4	6	119	0	111	170	0	314.00	37	70.11	CHANGED	REhSLFhp-s+asIluuuohlsc-.shP.......pah-lacss-ulpss..sslEcYThallDL+pGcloDu+sF+sDpIlLuHNpGlaLYsshLAILSlpaQsIaIapVs.-GcFlchRTIGcFCp--Dthhlsps..........pthsssshcpshh.P.....hIsuLKpRlLsFLaRpAcspuussupt.....R+FY+pF-pacpLhMWKMQLLDcchLLIKY....uopDlssL+ss-ss..psShFVlYsIhspplluVYpNsSscLLpLaEpFsDpFRsushtp.t.sFtsSsouNsaup.hppphKpThl..NtchuuppcAs+RlhuuLPlSuQSYSuSPYLDhuLFSYDDKaVSshERPKsCu-aPI+Fhu.RcouLLKF+lpAGspspssPts.sRRLVAFlFHPh-PFAlSVQ+s..stsYlVNFHhR+	..............................................+-h.Lahcssphslhuoush.....pp....s.s.................................sstulpss.....sslEchohallcL.........p..sG..hlhDphhapsDhl.Lu...HN.GlaLa.....pshLullSlp.QsIalh.plt....p.G.p.hlpl+.sIGtaCh-DD.hhlps.........................t....tt..h.s..................hlsulK.pRlLsala+ph.ptts....s.s.......+cFa.hFpth.pLhhWKh.QhLDpp+LhlKa...........sS.Dsssh.Rss.........-............psuFFsVYNh.oo-lluhap.NoSp-LhpLFEpFsDhF+sss.ps.h.pF.sStSss.aAhp...pp......hK........stphusptphs++hLsp.LPhSsQSh..SsSPYhDhsLFpYD-KhlS.sh-R.+tss-pPI+Fhs..R.p.sshlKFcltsu............tt.....s.t.s+.+lsuFhFHPh.PhulSlQps............hlshHh+p.........................................	0	38	59	86
+9570	PF09738	DUF2051		Double stranded RNA binding protein (DUF2051)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2010)	Family	This is a novel protein identified as interacting with the leucine-rich repeat domain of human flightless-I, FliI protein.	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.13	0.70	-5.13	7	400	2009-01-15 18:05:59	2007-06-19 15:58:51	4	3	88	0	181	356	0	199.10	31	66.18	CHANGED	AEARLAA+RtARAEAR-IRM+ELERQQKE..................-pp.D+.a....scpsSpst.ssl...s..............sshsGo..SSRRuStD...Sh-p-s.ShR-l........................+cpLtEVEE+a+KAMloNAQLDNEKsshhYpVDhLKDpLEEhEEphAphpREhcEKp+-hct.K+shshLphphp.l+ppLppRDpLIpcpGLllls..ssNu-su-p.s.......su.shlptEstplLpss...tGsLDV+L+Khs....sEpppL.tplpp.ptpLpth..ptp..h.utpsGsh...........p.........sQ+-uNK.Io-hKhKL.sKu.EpElsNh	............................................................................................................................................................................................................pp...cpth.........t..op......t.t......................................ss.tst......uS+...R....us..t.s......t....t...................................................................................................-+tt...plchhpc.h.p.pp.h....+p.......-.K.............p...-.h.E.+.pKchhshlp.pht-l+-tl...pptcchl.............p......cp...............................................................................................................................................................................h......................................................	0	26	42	93
+9571	PF09739	MCM_bind	DUF2044;	Mini-chromosome maintenance replisome factor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2545)	Family	This entry is of proteins of approximately 600 residues in length containing alternating regions of conservation and low complexity.  The Arabidopsis protein is a replisome factor found to bind with the mini-chromosome maintenance, MCM-binding, complex and is crucial for efficient DNA replication.	25.00	25.00	27.70	26.20	17.10	18.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.72	0.71	-4.57	37	164	2009-01-15 18:05:59	2007-06-19 16:02:28	4	7	136	0	117	167	2	120.10	29	19.86	CHANGED	cphLpsssshp...plP.lNss.slctlps........ssLVRFRsMlQDh.hssEhYlusYcstst.......hcssKYp.Dhhphs.ttth..........pshhhERpshYsVPlPGpssWstppppt.........phtstspssssppKR	..........................phLpppsshp.lPsLsps...slchlps.........soLVRFRsMlQD...M.hsPEaYhusYcshsppst.....hh+tuKYc.Dshpssstpph..ts......psshhERpshas.VPVPGpssWs+pt..s.............t................................................	0	51	67	96
+9572	PF09740	DUF2043		Uncharacterized conserved protein (DUF2043)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2374)	Family	This is a 100 residue conserved region of a family of proteins found from fungi to humans.  This region contains three conserved Cysteines and a motif of {CP}{y/l}{HG}.	20.10	20.10	25.70	21.70	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.91	0.72	-10.64	0.72	-3.96	9	103	2009-01-15 18:05:59	2007-06-19 16:10:46	4	2	75	0	68	99	1	104.60	44	16.58	CHANGED	ths+APlVPaGhDLpYWGpEp.sssp.hp.sspH+FWt.s-.EppVsusclsphhppRplTatGchcslp+h.CpA.h.sGtLCpRpDhhpCPFHG+IlPRDDpGpPlppED	.........................................t.ucAPVlPaGhDLpYWGpcp.ss.......suph...hp....sspHRFWtss-s...-p........plssscluEhhppRpIoFsGchEPlp+h.C+APh.s.....s.Gp..LCpRpD+h.K.....CPFHGpIIPRD-.p.GpPls.p..............	1	23	34	50
+9573	PF09741	DUF2045		Uncharacterized conserved protein (DUF2045)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2465)	Family	This entry is the conserved 250 residues of proteins of approximately 450 amino acids. It contains several highly conserved motifs including a CVxLxxxD motif.The function is unknown.	25.00	25.00	25.80	25.10	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.51	0.70	-5.23	3	168	2009-01-15 18:05:59	2007-06-19 16:11:30	4	8	105	0	103	160	1	208.10	41	49.25	CHANGED	V-pcosFWTslFssYFlcphEsR+p.D.DDLLFFVR+KLupuSS......RshsEsEsElEVY..RRDS+KLPtLGDPD...VDWEESVYLNLIlHphDYTVTlAICTRsusK-........Lpll+K+SQpVYASPSR..++MDSKGEsEcI.oYPcICFMVDsFDEVFcDllVsDGE.MVCVELVAoD......................+ssosQGVIFpGSIRY-ALKKVYDuRpSplGS+hAQ+MSFGaap....po+sEFVRMKGPQGKGHAEMAVS+Vss	..........................................h...t.haWp.hFspaFh...t....ph....tsp.p.............DDhLFaV+.p.hs.htu............ht...s..p...psplpVa...RRp.u.KLPt.ls-ss...................lDWEcolhLNLlhpp......h.sYhlTsAlCo+sssts....................lp.h.p+hoppVaASPS+..+.MDo.K.G................-..p..pl..oYPpIhFhlDsF--sFsch.hl.t-.sE.hhCVpLsApD.....................................................+.psshp.sslF.G.lpYpsl+.csYDs....phS...........hu..u................h.h..S.hGh....................s.ph-hlh...M+GPpG.+GcsEhAVots..s.............................................	0	35	50	76
+9574	PF09742	Dymeclin		Dyggve-Melchior-Clausen syndrome protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2225)	Family	Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteristically about 700 residues long and present in plants and animals.  Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterised by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation [1]. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus [2]. 	25.00	25.00	27.20	27.20	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	678	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-13.23	0.70	-6.42	25	291	2012-10-01 19:21:38	2007-06-19 16:27:57	4	7	170	0	171	566	11	481.00	28	87.39	CHANGED	MGss.S...................t..chphpph.......hthhssppsss.ss-sF..WspLhph.hphspssp-hh..lsut..phhpshh.sNhsohshttlhphhhtp........sphttspcpps.........................shNslhllspllp..ahhE..p.tpsphhthhhtt..t..........................................................shst....t............................h.shsphEphhpshls.hhss.ss...............sstp.th+hEhlplLLshhSsplatsssst........ss.ahphhhp...tpsptsssLhsoLLpphhphssssh........ph.hht...................uhh.hhsts...hh...............................sst.sp+sPLu..stulplLLlLhsapss...........................psNsapp..slshhpchcp............t..hpu.sp.ts..h.lsastL......hsol............sp...hhtppphllLLYpLlcpNppFhpYlLs.+uD.lpslllPILphLasuppc..................................................psphlahslhlLLlLSpDpsFspslpch........................h.hssls.Wh..p-hslt..........pho............lGuLlllVlh+hIphNhp...+hp................sh.LasssLuslsNhSsah+sLshhsup+LlsLh-hLop+ahphssthspch............................t.........h.hhpphl+hlLEllNuhls..hplctNspLVYsll+......+R.plFpphps........c................................................................................................................................................shhpcl.lpsItpl..Lpaasspl-.....phsssp...hs............hsclLchIpcushs..............................sstslp.....................as.lhacYppcptsppaF.hs........YhWsl	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hhh..h.s..hh.........................................hh.......................h...hl..h............................................................................................................................................................................................................hs.....p.sh.lLllLhp.hpt...........................................................t.s.sapt..hl..h....ts.p..............................................t............h..pl..s.hs.L.............h.psh................................st......tppp.hlLLY...LlctNpphhp..ahh..psc...h.pl.....l.hPlLph.Lapstpp....................................................................pst.lahhLhlLLlLo...pDpsFst.pl.pph.......................................h..h.sls..ah...t-..+.h..t.....................phS.....................lG.uLhllllh+sI.p.hsht...+hc.......................s.hL.asssLshLuN..h.....u.s.h+p...Lp.asup+lls....L.hphls++...at+h...p.hppph..............................................................................t.........................lphhpchl+hlLEIlNuhLs.....................tL...pNsplVYsllh......cp.plFp.hts............p.........................................................................................................................................................................................................................................................................s.htcl..hpsl..h...lthh...h.....................................t........s........................................tthhthl..t.s..............................................................................h.................................hhh.....a.tp.....ah.h...................................................................................................................................................................................................................	0	77	102	141
+9575	PF09743	DUF2042		Uncharacterized conserved protein (DUF2042)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2235)	Family	This entry is the conserved N-terminal 300 residues of a group of proteins found from protozoa to Humans.  The function is unknown.	23.20	23.20	23.20	25.10	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.61	0.70	-5.09	17	181	2009-01-15 18:05:59	2007-06-19 16:28:15	4	6	143	0	136	188	1	250.30	35	35.86	CHANGED	ElpcLttcFpcsQhsp.ssp+LSERNClEllpKLlccphl-..llaThDGKEYlT.spLppElpcELhspGGR...lsll-LspsLNVchs+lEptspcllcps..slphhtGpLlscsYl-plspElN-cLpEpGplslu-LsppacLss-Flp.pllpt..hhuplIpGphsts.....hlaTpsalpppcuplRGsLhAhTcPsslsslhpp.............hthppplhhsllpsLlst..splpGphhG......u.YlPphYppspsshVcsaacQNGalEassl.ppLGIsssppalp	...............................................ElpcLttphptsQ.sp...ssp+LSERN.slElls......KLhppp.hl..-...llaThDG.KEYlT.tplp+Elp-ElhhpG........GR...lsllDLt..phlsVDh..+lEpphpclhp.....ppt...p...........l..p.ll....G.p.LlspsYl-plspElN-pL.........p-p..Gplslu-Ls.ppasLsu.cFlp.phlpp....clGp...lIpGph-ts.................hlaTpualsRp+AplRGhhsAlT.+...Psslsslh..pp...............................................hsh....p.....pplhh..sllppLlpp...upltGplhG.....tuhalPslaspsQpphVcsFapQNuYl-a-sL.p+LGIscshpal.................	0	55	74	112
+9576	PF09744	Jnk-SapK_ap_N		JNK_SAPK-associated protein-1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2077)	Family	This is the N-terminal 200 residues of a set of proteins conserved from yeasts to humans. Most of the proteins in this entry have an RhoGEF Pfam:PF00621 domain at their C-terminal end.	24.10	24.10	24.10	24.10	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.11	0.71	-4.24	6	354	2009-01-15 18:05:59	2007-06-19 16:29:01	4	5	89	0	191	319	1	144.20	40	16.80	CHANGED	VpsLAsuIY+EFERlIcpYsE-VlKpLMPLVVsVLEsLDulhu-NQ.ch-lEhpLLc-DpcpL.sQYEREKpLR+pAEpKllchEDshEpE+K-Lpp+l-phEppsRpLELKhKNhs-pluRLEEREs-hK+EYsuLH-RaTcll+sYlEalERs+hph	....V.slAuuIhpEFERlIcpasp-.sVppLMPlVVsVLEtL.........-.........slhs....cs.......p..cpcl.Elc.hL+-..DsE.pL.sph....c....c....EKth.R+p.t...E.....p....chlc..h....E....DshctEp+...-Lpsp.lppLEp.ps...+pLp....hch.+.N....h...u-...p..................h..s....+....L....p.EcEsp..h..+pcas.slpp..RcsphhpphhEhl-+p+...................................	0	48	65	126
+9577	PF09745	DUF2040		Coiled-coil domain-containing protein 55 (DUF2040)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2117)	Family	This entry is a conserved domain of approximately 130 residues of proteins conserved from fungi to humans. The proteins do contain a coiled-coil domain, but the function is unknown.	25.00	25.00	25.60	25.10	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.76	0.71	-4.32	30	288	2009-01-15 18:05:59	2007-06-19 16:33:23	4	10	235	0	203	277	2	119.30	38	29.80	CHANGED	+pscpctpcAhp...pDsolasYDulYDsl+.tt.pctppsp.pscsp.+cPKYhssLlcuA-pRK+-pphspERpLt+EREtEG-pauDKEKFVTuAYK+phEE.++hpE-.Ecc+-chEcppctspttshh	..................................p.pschphpcAht...tDsola-YDslYDphp.....ttpp...cpp.t..t.h.......t..pp............++P....KYIpsLlcuA-hRK+.-pphthE+plp+EREtE.sc...c..F...sD.K.EtF.VTuAYK+p...hpEhcch-Ec.E+cc.pthEtptchsptts.u....................................	0	73	110	159
+9578	PF09746	Membralin		Tumour-associated protein	KOGs, Finn RD, Coggill P	anon	KOGs (KOG2092)	Family	Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers [1]. Membralin-like gene homologues have been identified in plants including grape, cotton and tomato [2].	23.70	23.70	24.30	24.20	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.39	0.70	-5.41	3	172	2009-12-07 11:10:06	2007-06-19 16:39:37	4	5	100	0	123	196	0	233.70	36	53.94	CHANGED	uQNPLINVRDRLFHALFFKsAlTYAcLVP+sVRRsIEFllLLKALLsFFILlYIHluFS+oPsTCLEHVKNcWPRDGILRVEIls.suc++sIaLpht-ssollRslK-suhhuI-PpTcpsHEolEpYQNsplKLpLslcPosahssppLps....pFDuENhosThSascAhSht.-sWs-EQYIVEYSLEYGFLRLSuSTRQRLNIPVhlVsLDPs+DKCFGDSFSRFLLKEFLGYDDILMASVKsLAEQEENKGYLRNVITGEHYRFVSMWhMARSSYlAAFsIMlLFTlSVSMLLRYSHHQIFVFIVDLLQMLEaNlSlRFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWlADQYDAICCHTSlTKR	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................YshEhGahh.Ls.ts+tchpI.sh.lplss.pp.C.FG....sth.pphllpphlGYDslLhsSlht............p..spG.aLhNh.otEhY.............p......h.....s.....................h..................hths.s.....a......s........s........hh...hhhh..h.....o.htluhhL.R..spp..phhhFh...h...pl........p.....hhphp.s....h.......h....hh..hshl.......hhl.G..h.hhh.EFasDp.hAFhlllhVWhs-.ashls..s+osho..........................................................................................................	0	49	64	103
+9579	PF09747	DUF2052		Coiled-coil domain containing protein (DUF2052)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3044)	Family	This entry is of sequences of two conserved domains separated by a region of low complexity, spanning some 200 residues. The function is unknown.	25.00	25.00	31.80	25.20	23.90	23.60	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.46	0.71	-4.35	20	236	2009-01-15 18:05:59	2007-06-20 11:01:27	4	7	195	0	184	239	0	155.60	26	58.63	CHANGED	NRRhthLppLlpcu-YFS-ppMc.R-PLLY-phlGpa.oppE+pscspsc...t..........uhuulLhsslp+pptchpltcpp.....p.-t.t...-pcspt...................p.p.s..sp..t-p.............ts............................ssp-+-.hc-cFhshMpp+FLsGEDcD.FDYopVDsss-aDD...c.hppDcEE+YF---	.........................................................NRRhthh.pt...................ps.......p....YFS...t.th........c.t......pPhLYcphl.....tpa.s.t-tptps.hc.................shushL.t....ph.cp....ph.p..t.h.tp....................................p...............................................................................tp.....p.....t.......................................................................ssppcp.htppahthMpp+FL........pGc.Dp-.aDYst.lDpst.phDs.........tpDtE-+YF---....................................	0	65	102	150
+9580	PF09748	Med10		Transcription factor subunit Med10 of Mediator complex	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3046)	Family	Med10 is one of the protein subunits of the Mediator complex, tethered to Rgr1 protein. The Mediator complex is required for the transcription of most RNA polymerase II (Pol II)-transcribed genes. Med10 specifically mediates basal-level HIS4 transcription via Gcn4, and, additionally, there is a putative requirement for Med10 in Bas2-mediated transcription [1]. Med10 is part of the middle region of Mediator [3].	21.50	21.50	21.80	21.90	20.30	21.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.50	0.71	-4.32	18	291	2009-09-10 23:46:38	2007-06-20 14:56:13	4	7	256	0	209	273	0	121.30	33	74.23	CHANGED	hppplcplIEshhpLslhVp-Fp....P.......................soppsLtp+lssLlpsLpplpchspp...............................hps...............lp..lPlEV.lpYI-sGRNPDlYTREhlEt.shcpNphh+GKhcuh+chRcsLtcElpcpFP-hhsphcsI	........................................................l.ppplcphlpslhpltlhVpsap.....s..........................poppsLsp+lp...pl..lpsLpplschppp...................................................hps...............lp..lPhEV.l.cYID..p...G..RNPplYT+EhlEt.shtpNpthKGKh-uhc.pF+shLhpElspsFP-.htphctl.................	0	67	112	168
+9581	PF09749	HVSL		Uncharacterised conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3102)	Family	This entry is of proteins of approximately 300 residues conserved from plants to humans.  It contains two conserved motifs, HxSL and FHVSL. The function is unknown.	26.80	26.80	27.80	27.40	26.40	25.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.62	0.70	-5.35	27	269	2012-10-03 21:31:48	2007-06-21 09:20:52	4	6	231	0	194	278	2	211.80	23	79.87	CHANGED	PPlPpshh-hhts......t.p.pDs....sshHsGRhRsh.HhcGNWsoa....lY..lthtsspt...hchlpphlsp.hpphhhhhphp................sth.....s.h.LHlSLS+slslcp.cphssFlpplcptl....sshpsFtlphss.lp..hhsNt-cTRhFLsLclsp........spsst...LpcllptlscshpcashsshY..........................................psspFHlSlAWsl.ss.ptphp...ct..ph..phhpth.p..................phpsspl+s+lGNpshshsL	..................................................................pp.....t.ctuRhRt.h.H.pGsWsoa....lY....l...h.....sptt........hp.......hl.p.tlltp.htp.h.t.................................................................tshHlSLS+slslpp.cthpsFlptl+ptl....................sphpt.....Fhhphsp...lc..hasN.p....-p.TR..sFluLpVsp.................................sttp......lpp.llp.hl.spshpp....a..shsphY...................................................pssphHlSlAWsl.ss.ptphp...t...p....p...p...htth..........................................ph.hpplph+.Gpthhph.........................................................................	0	55	93	149
+9582	PF09750	DRY_EERY	DRY; 	Alternative splicing regulator  	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2548)	Domain	This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins.  This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA [1]. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains Pfam:PF01805 and an Arginine- serine-rich binding region towards the C-terminus.	25.00	25.00	27.00	27.00	24.30	24.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.64	0.71	-4.01	17	271	2009-09-10 16:58:51	2007-06-21 09:30:53	4	11	117	0	173	284	0	124.10	33	17.96	CHANGED	p.LplaGpps+latDsthAtAs-ssptL...hPW...Gspp.hIDRaDsRuhL....shh.......ttsp.sp..phs..ppttEphhshERYhsLhpsch....................ptthppcpppphsppptp.tshsslGFoYssst	........................L.VaGhuCKla.hDs.thAhst-psppL...lPW.......G........D..p..shhIDRaDsRutL............chh.........................ts..sp.hpho.tEptp.Ephss.ERYhsLhpspht................................................tt.pc-chpphtpt.....t..t.tthsslGasYtss.s.....................................................................................	0	60	85	130
+9583	PF09751	Es2		Nuclear protein Es2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2627)	Family	This entry is of a family of proteins of approximately 500 residues with alternating regions of low complexity and conservation where the domain similarities are strong.  Apart from a predicted coiled-coil domain, no other known functional domains have been characterised. The protein appears to be expressed in the nucleus and particularly highly in the pons sub-region of the brain. The protein is clearly necessary for normal development of the nervous system [1].	20.20	20.20	21.30	23.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.70	0.70	-5.06	34	313	2009-01-15 18:05:59	2007-06-21 09:35:03	4	10	226	0	243	314	2	326.40	27	74.37	CHANGED	cptpVLsE-sYlpsLpcIIpRDFFPcLhchpspp-Y...................L-Al-spDhphlpphp....p+hpphht..............oPsphcss...sh....st.s.....ssspsss.ssh......tt-p..t...ttptt................................phuLspF.s+YTSEDNcSFpcll-ptppKcp.cKauWlap.scttpspplt.t...............................t.p.ssppt.....lc..........................sp.st............................................................................................-tW.ph+scNsLMahPsuspss..-sltptsct.........pclhapNTRh................pt.s.shsps......uhstlpcAhttp.p.p.sch.....ssc..........oPc..........VNGY......uaVcss.pPss...............t.sPlhTaGclpsT....Phpl-s.c..s.......tsss.......................ssFpI.Ess+REpluc+hsccsu.tKppp+p..............tpshsos.....t..ss.tls.........................LoPAA.Q+L	........................................................................................................tlLcE-pYhpslppIItRDFFPsl.chpspp-.a...................L-A.pptD..hhtpht.......chtphh.................................s.ht..tt..................t.....................................................................................................................................................................................................t.thoLstF.t+YTSEDNtSFpclh-ptpp+pc.t+aualap..s...c..ttppht................................................................t..p.....ttt...........hp..............................................tt..t...........................................................................................................................psW..p.h.pscNsLMahPp.uht......p........pph....tt..p......................pl.apNTRh..........................p.....shs.p......................shstlppshthpst...tp..........s.t.............oPp..............ssGa.......shVtss..pPtP...................t.t..sP.....hh...T....WGplpsT....Phhlpstp.............s.s............................ssF.+......l.-sspREplthphspcsu.tp.ptpt.................tt..to................s..th....t................................hoPAhp+h.........................................................................................	1	103	146	204
+9584	PF09752	DUF2048		Uncharacterized conserved protein (DUF2048)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG1551)	Family	The proteins in this family are conserved from plants to vertebrates. The function is unknown.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.00	0.70	-5.57	11	211	2012-10-03 11:45:05	2007-06-21 12:56:45	4	4	135	0	126	523	39	304.20	34	88.08	CHANGED	o+FFs+GWGc............chlcclhs.ct.lppR.......sPsshtlclspshppcssp.....lt-GpFtSPht..hsuhLPspucpA+hphLlPpph....h...+slCl.HLAGTGDHsah+Rcph.AcPLLK-.sluullLENPaYGtR+PppQptuuL+sVSDlalMGuuhlhEupsLLpWhccc.GaG..lGloGlSMGGpMAuLsuoshPcPlu.....lVPhLuhsoAssVFTpGllppulsWchLcpp...............................................................................................................................................................................................s.t........tpppsts..pEulR.hhthh.stTslpsFssPhsPphsIhVsAccDuYV..P+pust.sLpphWPGuElRa...l-u.GHVSAhlhHpchaRpuIh-Ah-R	................................................................................................................................................................................................................................................................................h...........t................pu.F.os......thhP..s....A.hhthlh...........Ptt.......................c.hsl.pL.A.GT...............G..D.H.h.a.+Rhph..utPhlKc..thuollLE....sPa......Y....G....R.+....P.t...t.Q....h.....t.S...p...L....p...s..V...S...D.....l...h...l..h.G...t.s...h....lhEst.sLLp.Whcpp....Gau....lGhsGlSMGGh...hA...u....lsso....saP...c...P...hs........hl.P..hL....o...........s.............o.....A.ss.s....Fsp.G...l..h.......p.....uh.s....W..t....Lp..pp....................................................................................................................................................................................................................................................tp..p.p...p.....hEs.l.......h.h....h....t.hh..p.h..T..c..lts...F..s..s.Ph.c.s..sh....l......lhVtApcDuYl......P+p...ssh..pLpch.W....P.G.s.E.lR..a...l..p.u.GHloualh+...p...thFRpsIh-sht........................................................................................................	0	47	65	99
+9585	PF09753	Use1		Membrane fusion protein Use1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2678)	Family	This entry is of a family of proteins all approximately 300 residues in length. The proteins have a single C-terminal trans-membrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are essential for membrane fusion and are conserved from yeasts to humans. Use1 is one of the three protein subunits that make up the SNARE complex and it is specifically required for Golgi-endoplasmic reticulum retrograde transport.	29.40	29.40	29.40	29.50	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.61	0.70	-4.94	11	304	2009-01-15 18:05:59	2007-06-21 14:54:11	4	8	223	0	200	291	0	221.70	20	82.89	CHANGED	S+LElNhhRLLu+CEthAp...EcpppspWRLcKaVsuLccMlspLccp..........hsKPos-hlsEYsc+lshLKullpupch.............................soss-KshssphLusups.sthsptcssso+p.............l+.pppu+hpsEhRpELls................sssuhp.ptshhtpp...........................ts.sssccpussclDphlphHpslQEKLA--MltLARNLKppo.sApslIKpDspsLspSt+hsDpNlspLppES-RLEpHupKusp..hahWlMlhlVhhhFIsMlLFI+lh	.......................................................................................................................................................................................................................................................................................................................................................................................t.thh......th..cht.lt...ht....p....................................................................s.....ptt...tp..s..t............p..t.s.t................................................tt..........sphRp.chht..........................t..................................................................................t....t..pt.ps....ttph..-t.hp....tpcphQEcLsc-hlpLAppLKps.ohs.h.ppslc...pDpphLsps...tcth-ps...h...pphppt....sp+...l....pp.h..t.p.p.s.hp........h.hhh.........h.....hl...h.h.l...hh.h.F.l.....hllhh+h.........................................................................	0	63	103	159
+9586	PF09754	PAC2	HCCA3;	PAC2 family	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3112)	Family	This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 247 and 307 amino acids in length. These proteins function as a chaperone for the 26S proteasome. The 26S proteasome mediates ubiquitin-dependent proteolysis in eukaryotic cells. A number of studies including very recent ones have revealed that assembly of its 20S catalytic core particle is an ordered process that involves several conserved proteasome assembly chaperones (PACs). Two heterodimeric chaperones, PAC1-PAC2 and PAC3-PAC4, promote the assembly of rings composed of seven alpha subunits [4].	22.60	22.60	22.60	23.60	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.33	0.70	-4.49	126	1323	2009-01-15 18:05:59	2007-06-21 16:27:51	4	4	791	13	568	1106	677	221.70	21	77.96	CHANGED	hlpGhsssGpluplAscaLlcph..chchlupl.ps.phhs.....Ph....shhpc.s.........thhhsshclYhsps..tt.....................lllltup....s.ss.hthp.......paspt.llshscchslppllsLuuhsssh.c..pps...slhshssspchh.pphp.............p.ppht.....s.sGssuhlhths.tptshsuhslhstss........................t..hs.....sPpAutsllc..sl.sch............hslpl.s..hspLtccA...p............-hpphlpp.Lpc	..................hhpGass.sGpsuphAsctLhpph............ptchlupl.cs.-thhsh.sp......pPh...hthps.s......p..........thths..shplahsps.tt.....................sllllpG.....spPs...hpac.......paspp.lhshs.c.ch..s.lppllsLuulsssss+........s+s....hslhs.hus..s...sphh..pphp..........................htchp............sss.u.hss.ll.tth.tppsh.ss.ls.hhstlP................................pY.hs........sPtAshsLlc..tl..pch.............hslpl..s...hs..sLtppApphp...............Eltphlpt.L..t..................................................................................................................................	0	182	378	494
+9587	PF09755	DUF2046		Uncharacterized conserved protein H4 (DUF2046)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2129)	Family	This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.	20.70	20.70	20.80	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.12	0.70	-5.54	3	169	2009-09-10 16:40:10	2007-06-21 16:31:04	4	5	127	0	120	159	5	230.70	45	56.20	CHANGED	A-CsSESDoDGuTscsSSouSp.........EcLpsRIcSLpQENKVLKhELDTFKLKCKuLQEENRsLRQASVoIQAKAEQEEEFISNTLLKKIQALKKEKETLAhNYE+EEEFLTNDLSRKLsQLRQEKscLEQTLEQEQEaQVNKLMRKI-KLEADTluKQToLEQLRREKVDLENTLEQEQEALVNRLWKRMDKLEAEKRhLQEKLDQPVS-PPSPRDhh..oputDTsssluSHI+uLRSEVcRLRcNLAsSEt-aTEKMpQYAcEERphREENIRLQRKLpREVERREALCRQLSESESSLEMDDERYaNE.l	.....................................................................................................................................t.p......hc...phth.+h+sphltc.-.+tL+psuV.lQu+AEQE..............EEaISNoLhKK...Ips.LpKEKEsLAhpYEpEEEhLT.....NpLSR.KL...QL...ppEKs.cLEppLEpEQEh.VNKLh+....+Ic.......+....L..............cs-p..s.pp....p...............LE.......pLR+...Etl-.LENsLEpEQEhLVN+LhK+h-cLpsEKR...LQ.+...Lpp...hs...t.s..s.....t...................t......t.............h..lptEh..p..............hpt.h.........................c..........pthttpNhphpp.l..phtch.th.pt.......................................................................................................................	0	59	73	99
+9588	PF09756	DDRGK		DDRGK domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3054)	Family	This is a family of proteins of approximately 300 residues, found in plants and vertebrates. They contain a highly conserved DDRGK motif.	23.30	23.30	23.30	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.26	0.71	-4.89	16	209	2012-10-04 14:01:12	2007-06-21 16:39:39	4	4	157	1	132	209	5	164.80	40	57.11	CHANGED	tclupKcttKh.ptKpt++ppREhEctpREp+c+hptp+.tchppp.....c-pcctpcpccEcpccctcEEpcc+EpEEYp+hKupFslE-pGppptps--ptp....hlpcFIsYIcppKlV.lE-LuscFsl+Tp-sI.cRlpsLptpGplsGVlDD.RGKaIYIos-ElpuVspaIpp+GRV.ohs-LsptsNcLIs	.......................................................t..hst+chtKh.ptK.pt++tpR.c....t-pt...t.REpR+.phpptc-t.ch+cc.................--cpc.pEppcEE.tp+p.t.+E....EpcccE...p.EEY.+h..KtsF...sVEE..EGhtpp.sc-ppp.....hLpcFl.pYIKppKlV.LED.LAupFtl+Tp...-sI.sRIppL.spGploGVh.DD.R.....G.KF..IYIo.-EhtuVApaI+p+.GRV.SIs-LuptSNplI............	0	53	73	106
+9589	PF09757	Arb2		Arb2 domain	Wood V, Bateman A	anon	Wood V	Family	A second fission yeast Argonaute complex (Argonaute siRNA chaperone, ARC) that contains two previously uncharacterized proteins, Arb1 and Arb2, both of which are required for histone H3 Lys9 (H3-K9) methylation, heterochromatin assembly and siRNA generation [1]. This family includes a region found in Arb2 and the Hda1 protein.	19.20	19.20	19.30	19.20	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.12	0.71	-4.84	43	409	2012-10-03 11:45:05	2007-06-21 17:39:30	4	19	222	9	275	398	1	154.40	20	27.75	CHANGED	sPcchhp.........hphhcpshh.pppaacshtp..............................sI+ph.hpcLppc.thl....LP................hsshsp.....p.ts.Ihsosshh.pspp..lllllHsssp....lWAppss.hsssl-suosls.......................aIphu.................................tpcshullslNhsphhhp..........t.t......sshpsshpsp-hsthla-s	..................................................................................p............hphhpphh..ppthapsh..................................................................hlpph.hphLtpp...thl.....lP................................................hssh.p.....p.cs.lhh.S....shh..pspp..llllla.s.ss................Wupp.....hh..hs.....psl....ctuotls.......................alchA......................................hppsaullshN..sp.hh......................t.pt......t..........h...h.......................................................................	0	74	138	218
+9590	PF09758	FPL		Uncharacterised conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2219)	Family	This entry represents an N-terminal region of approximately 150 residues of a family of proteins of unknown function. It contains a highly conserved FPL motif.	21.30	21.30	21.50	21.50	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.89	0.71	-4.43	18	233	2009-01-15 18:05:59	2007-06-22 10:31:58	4	4	148	0	162	219	5	135.00	47	16.91	CHANGED	lRpIsEhlIWGDppcsp.hF-aFhEcslhsphhcllpp.p..sspslplpllQolohLlpNlppcpslaYlLSNsplNclIsapaDhp....c-EllsYYISFLKoLuh+LspsTlphFFNp+hs...sFPLhscAl+Fhsap-sMlRsusRsIlLsIh+	.................................lRsIsEllIWGDQpD.ss.lF-.........FFhE+shhshFlpIl+p..p..ssphVslQLLQTLsILhpNlppEoSLY...........YLLSNNalNslIs.....ac.FDFs.........................DEE.lhuYYISFLKoLSlKLNpcTlpFF..a.Nccss.................sFsLYsEAlKFhsH.sEoMVRhAVRTloLNVa+...............................................	1	72	100	136
+9591	PF09759	Atx10homo_assoc		Spinocerebellar ataxia type 10 protein domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2676)	Domain	This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localisation, specifically to the olivocerebellar region [1].	24.70	24.70	24.70	26.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.02	0.72	-4.28	20	296	2009-01-15 18:05:59	2007-06-22 15:02:31	4	5	255	0	203	293	0	93.20	31	16.29	CHANGED	uhKppllcllusLsacsp-lQ-plR-hsG.ltllLssstlD-pNPal+EaulhsIRNLhcsNscNQchlupLcspsl..scsshLpchGhclpl.ps.G+lplcsp	.............................thKp.llpllusLs..acs...psQcplp..............ch..sG..l.hlLss.C.s....h.D....cp....NPa.....l+Eaulhsl+.Lh-sNtcNQchltpL.c..tpth.......spss..hLpp.hGhph....t.tp......p........................................	0	65	112	167
+9594	PF09762	KOG2701		Coiled-coil domain-containing protein (DUF2037)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2701)	Family	This entry represents the conserved N-terminal 200 residues of a family of proteins conserved from plants to vertebrates. In Drosophila it comes from the Fidipidine gene, and is of unknown function.	25.00	25.00	28.30	36.20	21.10	19.10	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.98	0.71	-4.22	14	147	2009-01-15 18:05:59	2007-06-22 16:15:42	4	4	105	0	94	146	3	172.80	51	30.58	CHANGED	php-Il-lLlsAGYaRARlpuLSsFDKllGGhsWsIpss.s.....aclDl-hhFpEs.......oIGpKIuloE+IlpsL.cM+CPapLcPHQIpGLDa.slaPVlpWLlK+slEsRpEpu-hl+pauhspFppcas.h.scp..-hhppcpcsspsltshpchatPpR.....hcR.tss.s.hhsc.ppscpsLhEYGp	.......p.hp-Il-LLVAAGYFRARIKG...LSsFDKVVGGMTWCIosC..s......aDVDVDLL..FpENu..........................TIGQKIALoEKIVuVLP..+M..KCPHpLEPHQIQ..GhDF...IpIaPV...lQWLVKR.ulEs+cEhGDalRpauluQ...FpKpap..hspDc......-hhpcpcpshcslhslpchYpPpR....ha+R..ttss.........pph.--tsclc.sTLLEYG.................................................................	0	35	45	76
+9595	PF09763	Sec3_C	Sec3;	Exocyst complex component Sec3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2148)	Family	This entry is the conserved middle and C-terminus of the Sec3 protein. Sec3 binds to the C-terminal cytoplasmic domain of GLYT1 (glycine transporter protein 1). Sec3 is the exocyst component that is closest to the plasma membrane docking site and it serves as a spatial landmark in the plasma membrane for incoming secretory vesicles. Sec3 is recruited to the sites of polarised membrane growth through its interaction with Rho1p, a small GTP-binding protein.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	701	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.38	0.70	-13.14	0.70	-6.40	24	414	2012-10-03 17:31:52	2007-06-22 16:27:39	4	6	269	0	278	545	1	511.00	21	63.19	CHANGED	p-...............u-shhccLs+ELspl-tss.lpsllpp-ppssplhphl.-pulsEsDcl-shLshaphpLpslp--lshIEspspGLQlpssNpKhLhpELppLLsplslscsplpsLpp.sslppsptlcth..EsuhtsLhpAhsslp.......................shcsshsphpAlpp+cphacchsppFhcRlspahpptFp.h..p.hpt.p..............chshppatshhppLhhYusLhhahK-lstcpaptLhptYpsphpplYcp-hpphhpth+tphp.......................................................t.pspptptsh.sss..........t..pph....hshpps+phph..................ppuphh.................................tp.p..cshtthLsphpslhhhcQsFl.pFF......+hss.......................................................shsas-hlpttssppppt..phsphp.hc.........ss+ths.pplpphhstlFts..h.scl.shls.s..phcsh......s.slLhhl-ptl.phpp..s..sps.aL.phlt+lhtplpp.as+alppQlctIEc.splsh+pp.GllshlpsFs.FsptsEshhppspp..............hssh.hl-puYp+lspuhhctlpphs.....t............................................ppppphspplshl....ENhpahhcpLs.........................hph......sslpshhcpupphaccphphYhp.tlltcshs+LhpFhpuscshlps.....s.sp.uhphuaSKptl+pllssYsu+-lcpslcpLh++l-KHF..t.p...........................shpcsLlp+lWpshpppalphap+ltsllp.csYss	............................................................hp..hcth.tplppclt.hptss.l......ttl..tp.-.....h.......p.lhphl.-tshtps-p....h....-.hlp.a.......p..L..pp........hpc...........pht.Iptpsphl..phpstNphhLhpclp.llpph.p.l.st.t.ht.Ltt..ss...h............tp.p......ltth........uh.hL.tsh.........................................hp.s.th...h..u..lppppt.htt.pt.Fhp+h.paht.ha.........t.t................................ph...tp.t.hht.lh.as.Lh.....ah+th....s.ttat.lhp........Y..p.hp...l.hppphpthht.hp.tht.................................................................................................................t.......................................tttt..t........................................................................................s.................................................................t.hhtthLtp.h...hh..EptFh.pFh.....php................................................................................................................t....t.ht.........tt............................................t.htthh..lht.....h..ph.thht.h...p...ssh.....................h.hhhhhpphh.....tt.....s.........stt.al...hh..tph...thtt.apc.hl.ppp...h............pthpp....scht....h....pp..t.Gllshh..h....h.thhEthht..................................................................................lsp..Y.pl.tshh..lphhs..............................................................plhhh.....cNhthh.t.l..........................ht........sLtt.hppAp.p.hppthp.Yh....hh....ht+l.tFhpthpthh.t........ht.tpl....sh..p.shs+t.hpcl................ltt..s.pp.....l.....ccslpthhc+hpKph...........................................pptLh..lhpt.hpt.hhp.h.th.thht.thY............................................................................................................................................................................................................................................................	0	107	168	238
+9596	PF09764	Nt_Gln_amidase	WDYHV;	N-terminal glutamine amidase	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3261)	Family	This protein is conserved from plants to humans. It represents a family of N terminal glutamine amidases. The enzyme removes the NH2 group from a Gln, at the N-terminal, rendering it a Glu.	20.30	20.30	22.00	21.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.65	0.71	-5.00	14	159	2009-01-15 18:05:59	2007-07-09 17:17:08	4	5	132	1	108	172	5	164.70	40	77.58	CHANGED	hYsSpYCEENVaKLsEhl...t..psshppha....AVFIS...........N-pKplPlW+Q+uups..sss.VlWDYHVIhlp.......sspsutshVaDLDosL......PaPs......shppYlpcuhps-..tplpspa.........RRpFRVlsucpYLppFuSDRSHM+ctsGsahpPPP.aPsIpsscus......hNLss.alsMp.pss.................GtVhs.sphhphFu	................YsspYCEENlaKLCc.l.....tt..p..t.....hp...cha............sVFIS..............Ncp+hlPlWcQ+uuts......sss...VlWDYHVlhlp..........................sssspshVYDLDosL......PFPs......sappYlpcsh+s-...sl.pspa..............+RhFRVl.AspaLppFuSDRSH..M.......+....c.s..s..G...s.....WhpPPPsYPsIts.sssp.....................NLsp.aIsMs.t.s...................G.Vhs.tph.p.a.h.....................................	0	44	58	85
+9597	PF09765	WD-3		WD-repeat region	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3268)	Family	This entry is of a region of approximately 100 residues containing three WD repeats and six cysteine residues possibly as three cystine-bridges. These regions are contained within the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2. The WD repeats are required for interaction with other subunits of the FA complex.	25.00	25.00	27.80	25.70	20.20	22.40	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.74	0.70	-5.13	9	143	2009-09-11 16:53:32	2007-07-10 10:43:26	4	7	100	4	91	139	4	227.60	33	69.28	CHANGED	LhcchPhLlsps.+ptshh.talusptpsa.+l+lhLPccspLcsu+lhs.hthcplhhthppsspp+lpps..L.uFl.cLcplLEstLKspsttps.....sphhosLhp-ltsltas+hshl..Dsshopl+Lpu.Dut.RpHhlTlclpuphshcss-asls.slshuhsht..puoLtshhspFlthLEsLcsFaDshc-IDEhsaVLEPppssppsosRhIslsppV.lplplcPtcPhhh.tshhLu...ss+.Vs.LRphLssslc.WDPEsslhpNLhclh-l.tFPh.	.........................................................................................................lph.....................h.h......th.........t..........p....p.ht.ps..l.thh.pl..ll..h.p...p.......s..........sphhsplhp-lt.tlGWsplh.l..ssshsplchph.Dst.tRpHhlplpl....s..paP....h....psP...s.h.sshPh....hth.pas.............p..............o...sLhslhpQFhttl-.pLptFWcshD-IDcpsWVL-PppPspus.s......hRRIslus..ssSlplpl.cPtcPphlP....pshhLu...ssp...................hlp.Lt..p..hsp.sh..phWssc....pslhpNLpplLph.thP......................................	0	33	45	69
+9598	PF09766	FimP		Fms-interacting protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG2216)	Family	This entry carries part of the crucial 144 N-terminal residues of the FmiP protein, which is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. The C-terminus contains a putative nuclear localisation sequence and a leucine zipper which suggest further, as yet unknown, nuclear functions. The level of FMIP expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.	26.80	26.80	27.50	26.90	26.40	25.10	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.24	0.70	-5.38	17	303	2009-01-15 18:05:59	2007-07-10 13:56:45	4	8	220	0	209	278	2	260.80	32	53.71	CHANGED	lpL+chsRhshhphccsR.cpscctKppVDttpLpLpNLhYEtpHLp.......KEIp..pCh-FKopct......cl-Lls.-EFap.cAPppls......csphsttspHp.hLtRLsaELpQRKcLscphccLpppKppltps.Itp+cchL.sSLtspL+...sltpuohPlQchlshsapp...p.cppc.......hsphLPtPLYlLYsplpuhtpsp-c......tlplpIh...Gs.c-Apshtpt................pspppspssp-sccppppp++Rcpptphp.sstp...pphhc.hHP..........Lplhlclhspct...............ltLpFp........YlspLplVsVpsphsst....................-slLssLFs.......sDsGp........chP.................p.ssph.hpchsl..pphsp...t..hG+PYpWsQpLsGlpah	...........................pL+thNR.shhph+ps+.ppTtcs+pclDthcLQLQNLhYEh.HLp..............pEIs...tC.pFc.s..+ap.......................pl.LlshE.EFhp...ptPtpht.........................ttscsHphhlsRLsaELpp...Rc..cLtpphpclhppKpplhp-..pp++chL.ssLt.cLp....plh.pAu..hPlQchh...th......................................................s..h..h.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	83	122	172
+9599	PF09767	DUF2053		Predicted membrane protein (DUF2053)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3236)	Family	This entry is of the conserved N-terminal 150 residues of proteins conserved from plants to humans. The function is unknown although some annotation suggests it to be a transmembrane protein.	21.70	21.70	21.70	23.10	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.91	0.71	-4.24	11	161	2009-01-15 18:05:59	2007-07-10 14:12:23	4	5	123	0	102	168	2	149.60	45	65.19	CHANGED	TLFHFsNChALsasPaalsYKsouLSEY.suhhpClpAussYlhTQLsKhllLA....TFhsss-s....ssashhsEhL...+t.hshlDlhGLhLllop...hssctch+llssGLGWuhA-slho+hlsLWVGARGhEFoWcYl.pul-uNh.LlpplshssL.lahhoR	...............TlaHFhNChALsa.hPaalsYKtosL.S....EY.su......hhp.Cl.pAussY.lhsQLsKhLhLA................TFass....-s..............s.a..-...hhsEhh...KsslDlhDllGLh....hlhop...hs.GKuchKlhssu..LGWAhA-hlhoRhl..P.LWVG.A.RGhEFsW+YI.hul-SNlsLV..phlshusL.lWhaoR........	0	39	53	81
+9600	PF09768	Peptidase_M76	Ku70-bp; 	Peptidase M76 family	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3314)	Family	This is a family of metalloproteases.  Proteins in this family are also annotated as Ku70-binding proteins.	25.20	25.20	25.70	25.40	24.20	25.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.29	0.71	-4.80	29	315	2009-01-15 18:05:59	2007-07-10 15:56:33	4	8	269	0	235	318	5	167.90	37	67.56	CHANGED	pppCpchhchhlphSPhVpFhhpplc+ls.......ss....hppppIhCc...................hCsst.........puGGFsP........ctGIllCpNpl...............+sctclEcsLsHELlHsaDch+hc.lDa...tNl+HpACSEIRAusLSG-C+ahpEhh+tshs...phtp.......paQcCV+RRAlhSVhuNPsCp.s.pcAccsVscVWcSCFsDTRPF-c	.............................................................................pcCpt.hphhlp..s.P..h.l+ahhpt..lcp..hu..........ss........hppppltCc...................................Cssp....................huGG.F.ss....................ptsIllCpNp.h..........................................................+sptcl..ccslsHELlHAaDahRh..c.lDW....pNl+HhACoE.IRAus...LSG-CpahpE.hh.+t.tht.....lpp..........paQ...pCV++RAlhSlhu.s.ssCp.........p.tpApcsVscV...a-sCasDpcPFs.......................................	0	83	133	195
+9601	PF09769	ApoO		Apolipoprotein O	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4798)	Family	Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL [1].	23.90	23.90	23.90	24.00	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.57	0.71	-4.52	36	346	2009-01-15 18:05:59	2007-07-30 13:28:07	4	5	224	0	212	323	0	151.40	23	63.87	CHANGED	hh-ccsstts.h.spphsh.....sspp.p.................................hsscssshLppthpphRhtltpthshsps...........thsshhsphhstccphpsshssLtsssps...lLPshhaIlluuluGsIluRpRuhhhRhhhPlshussuhshhhPpo....hcssuphhashEccthPsls	.............................................................................h.sppls.lhss......sttp.c.............................................hs.psss.LpptlsphRphhtshhshsps...........ths.pshsphhsh.p.t..hpsshs...Ltsssps....hhPphshIsluuh..sG.....llu...Rp...tuhhh+hshPhshushuushhhPtp....hpssuchhaphtpp.hssh...................................	0	47	90	156
+9602	PF09770	PAT1		Topoisomerase II-associated protein PAT1	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4592)	Family	Members of this family are necessary for accurate chromosome transmission during cell division [1]. 	25.00	25.00	25.50	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	808	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.62	0.70	-13.55	0.70	-6.30	17	499	2009-01-15 18:05:59	2007-07-30 13:30:45	4	8	240	9	328	497	1	425.60	16	81.25	CHANGED	MSFFGFDoohPtcptstst.tt..p..............................h.Fp-TYcG.LG-p.pE-sDshND-TFGssh....slG+DFDFtstpuphsts.tttt.........tsutss.tstsphs..................psppsshpttpssp.hscLpshsulWu...t....................tssttspstPpssststp.lphpthpt.h..........tt..t.st.s..shs.shsst...t.h..........h.sshsttas..ss..................tph..tst.t....tthsh..PsphPs...tht............ph.st..tsst.ptt............pttsPPht...ts.P.t.sp......tt.ssh....t.p...........................................tp.hphspppchshh.cc..................t++hp+pcchhth.......tKasGLMTPpDKsFITRlQLoQlV..........o--PYsEDFYaQVap........h.ttstppsppstsphApsYL.poGpR..........tt+h+pu-sshQRMQQQVp+AVp.............ts+t+sKtsphhh....EGuLGKIShu.suKsPRp.L....shcpspssp..........tt.pp.ssphshpc.........................................t+KpILphlEslYpplhclEshpRshs..................tth..hptchps.sppLWpsL+l....ps.ssss.p...........spPFIuhLSasKGhKllPRlFpalscEQcl.TllohIhspLspLsVlhpu...ss....Phhsh.........pcth-..hFptslhsslhsalsps.sat.lhuLLshllp.psslshlupo+IGLullThLlSRAEll+ps....u.ss...........upp-hppWsphashLFssL..s..lsslFPs.............s.ststptYl.....................WQFL..Aululuup.ppQphlV.tV+DclhtTlspuKpl.s.......................hhtppplpNlNLFLpshGLssc	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ssLGpl..s.s...tP+..l.......ph......t............................................................................................................t..hh...........lEthh..lhph-t.....p........................................................tth..thth.......................................................................................hhthhth.KGhhhh.Rhh..l.........t....t.h...hh.h.hh.th..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	84	140	233
+9603	PF09771	Tmemb_18A	Transmemb_18; Tmem18A; 	Transmembrane protein 188	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4606)	Family	The function of this family of transmembrane proteins has not, as yet, been determined.	25.00	25.00	25.60	25.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.56	0.71	-4.15	5	136	2009-01-15 18:05:59	2007-07-30 13:31:49	4	4	93	0	68	120	0	113.90	55	84.03	CHANGED	hEPS.ACEDLKAFERRLTEVIouLpPoThRWRIlLslhSlhTuluAapWLsDP....cTppVPhh-S.LWsHPhFTlSslsLllLF.lhGIHK+VVAPoIIAuRCRoVLAEFNMSCD-TGKLILKPRPpNssp	..................t......sE....DLKAFERRLTEhlpslpPuTtRWR....hlLlllSlCTAhGA.WpW..LhDP..................cTppV.sh..hpS.LWsHPhFTlSsl...TLlsLF.hhGIHK.RVVAPSIIsuRsRsVLu-aNMSCD.-.oGKLILKPR.....s................	0	23	28	50
+9604	PF09772	Tmem26	Transmemb_26; 	Transmembrane protein 26	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4610)	Family	The function of this family of transmembrane proteins has not, as yet, been determined.	20.20	20.20	20.70	20.60	19.30	20.10	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.02	0.70	-5.19	10	150	2009-01-15 18:05:59	2007-07-30 13:32:27	4	2	77	0	112	137	0	235.10	35	74.38	CHANGED	llshLpAllTRlLFhlHulVuVWpVshlK.c-shYWhLslsllLLslEslhTlhh+KGcEaKWFsPSlFLYLsoIlPulWlLElchlpp+.............................sshucshcs.tpLhusluls...............httlsscsWstsLEQsLlLlLIlGRWLLP+Gc.lTRDQLSQLLLsYVGsAADIlEFh.-olKEspVt.....sNstlVhulLslWoWShhQFsLVLosTtsptscsusptcst.p........shhsphssDlWuIhlslllQDGPFLllRLlLhshacVIspMhlFFTsKNsLVllLQLYR	.......................................................................hhpAlhoRhlFhhHu.hlslWpVs.h......p.pp......haWhL....hh..hhL.hhEhhhTlhh+.cspt.....a......+WFsPulhhYL.sllPulWlLEhc..pph............................................................................s..p.p.t.......h...t.t..tht................................................lstpsWhhhlcQhhllhLIlGRWLLPh.Gs..lTRDQLSQLLLhalGsAADIlEFh.-ohcpp..pl..t.....pp.hllhhhLslWoWShlQFslsLssp..thh.....s.ht.ttt.............................s.p....hsh-lWslhhslhlQDuPFLhhRLhlhh.aplhs.h.lFFssKNhLllhLphYR...................................................................	0	52	61	89
+9605	PF09773	Meckelin		Meckelin (Transmembrane protein 67)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4611)	Family	Members of this family are thought to be related to the ciliary basal body.  Defects result in Meckel syndrome type 3, [MIM:607361], an autosomal recessive disorder characterised by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Joubert syndrome type 6 [MIM:610688] is also a manifestation of certain mutations; it is an autosomal recessive congenital malformation of the cerebellar vermis and brainstem with abnormalities of axonal decussation (crossing in the brain) affecting the corticospinal tract and superior cerebellar peduncles. Individuals with Joubert syndrome have motor and behavioral abnormalities, including an inability to walk due to severe clumsiness and 'mirror' movements, and cognitive and behavioural disturbances [1][2].	25.00	25.00	27.70	25.10	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	853	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.53	0.70	-13.40	0.70	-6.77	7	200	2009-01-15 18:05:59	2007-07-30 13:33:13	4	7	106	0	140	197	7	504.90	26	83.21	CHANGED	P.uhtspsspC.ssshhshhhssuCs.splhpuh.hshssssssshps.ssssh...s.hs.phsu..hhph..suAs.phhhushoACphLuNhCVh.hashsu...ssCtLapplhpst.t.........hhpthPhLaYucssshhp.l.sshshshphshttp.....LphlsusYDlcGshlthpslt.p.lpLCspssschpshashGsshphsCplshpcLl...tptspshFa-lalp..tsspchh.hslsh.hpshphpstphppsp.........................uh.phhhpRRhaLhDslsts+cts.p..........ppPphlpsspplplsh.lsspsppcplhsPllhlpYush.h....................sssphsshohulp...aphspssh..lhh.lshslhssLshhsuhhRThsWhRRpts.....hlshtslh+FhlahsscluNhFhhhshhsuhYhhlhaKhQpss.hhh.....spp.hhhpshlhsAhAhKulthLhclhpQsshDhFhIDWERs+uphhtppch.................sPVShWRohFVANEhNcLQslRphsPLhphhhlLFFL.sLsa.phu.psP.sott.sh.shs.s...hLRhuLsohhalhluLl.hlhchthahRFh..pPlppFVDLCSlSNISlhlLs-ppaGYYIHGcSlHuHuDssME-hppNLphEups.hs.RGLsspo...csQTaplhhs.phRpah.hhh.p.ptcpppu.h+t.ts.t...........hshppp.psYsshshhlpshIscsh+.shchh..h.hsK.hhcphLshtPs.hhhps.tp................sthslFahD-shuaupshhhG.-hsLhlh.hhlasslDluspNhhlAhslsaslphlh+ahRhp.GhtNlSpKTLID-RFhI	..............................................................h..............................................................................................................................................................................................................................................................................................................t.h........................C.................................................th.h.........................................................................................h.h..........................................................h.+Rh.hhpt..........................h....ph.h..........................s.h.h.h.............................................................h..............................................h.h........................................................h....t..s.h.h............................................h..hh......h..ht.h.hh..hh.....phFhlDWEp.c........................................................................lshWR.hhhANta.clp.hp.hs..hphhhhhhhh.hhth............................................................h..h....hah.h.hh.hhh...hh......p.h.tpFhDlsshuNlSlh.h.p..aGaYlHGcu.hshu-ssh..........ph...h..........tts....RGL..tt........p.psa.h.....hp..h..........................................................................................hh.thh...................................hth...........................................................................................................................................................................	0	74	84	118
+9606	PF09774	Cid2		Caffeine-induced death protein 2	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4613)	Family	Members of this family of proteins mediate the disruption of the DNA replication checkpoint (S-M checkpoint) mechanism caused by caffeine.	25.00	25.00	26.80	26.70	20.50	24.50	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.03	0.71	-4.11	22	228	2009-01-15 18:05:59	2007-07-30 13:33:41	4	3	202	0	153	219	0	140.50	30	83.25	CHANGED	Chs.stlcshLRh.Rp.lDDpIpppLNshhsssp............t.p.................t.ttCpphhcp.LhsuWpsRscllpaCtshusp.c.cssp............tpssptpcpthspRlDPYus+thpcE.pt.....psltphlpsEcsVEpIIRpRThplls-+Cth..pshp	........................Chs.tthp-hL+hhRs.lDDpIhppLNshhssup...hshc.............................sssppCcphhcp.LhsuapsRsclIphChs.ss..................................tpstp.+-ch.cpp.Dshsh+thtcE......................psh.hphlpsEhsVEpIl..psRohclhp-RCphp.p......................................	0	44	74	119
+9607	PF09775	Keratin_assoc		Keratinocyte-associated protein 2	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4615)	Family	Members of this family comprise various keratinocyte-associated proteins. Their exact function has not, as yet, been determined.	23.50	23.50	24.20	40.00	21.90	23.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.61	0.71	-4.60	8	113	2009-01-15 18:05:59	2007-07-30 13:34:05	4	2	96	0	73	121	1	122.90	45	90.56	CHANGED	MAVsouTShsLSolLhhLlFusMQMY+sQLASSphhTIhGGFLGSLLFlh.LTAluNlEsllhG+GFQsKlhPEVVlshllALhAuGhVHRVClTTCLIFSlsuLYYlNKIS.phat...ssslstssspKpR	...............................uoGsShhLSuLLulllFushQMYpppLASoEhhT..IhGGhLGShLFlh.LTAhsNlEphlFGpGFQsKlhPElllsLhlALhAuGhlHRVClTTChlFShsuLYalNKISpphaps...ss.s.sh..ttt..tt.......................	0	22	34	52
+9608	PF09776	Mitoc_L55		Mitochondrial ribosomal protein L55	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4616)	Family	Members of this family are involved in mitochondrial biogenesis and G2/M phase cell cycle progression. They form a component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.	25.00	25.00	29.90	28.70	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.31	0.71	-4.50	8	98	2009-01-15 18:05:59	2007-07-30 13:34:58	4	3	79	0	60	104	0	110.20	39	80.83	CHANGED	hLplLppsshpuss..s.p.hhsoshRssusRASloRl+RpsYuRLYPlhLVpPDGSTIpIRY+EPR+llphPlDL-sLSPEERRARlcKR+P..+pKlchp-El-DsFDsc+YhpFh.....+K	.................................h....................phhhsshp.hsS.s+.AuloRl+RpsYsRh.YPslLVpsDGSTIpI.RY+EPR+llt...hPlDLssLS.EE....R+sRLc+Rcs..p..p.K.hc.h..p.p..El..pDsFcsc+Yhpahp+...........	0	18	22	41
+9609	PF09777	OSTMP1		Osteopetrosis-associated transmembrane protein 1 precursor	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4617)	Family	Members of this family of proteins are required for osteoclast and melanocyte maturation and function. Mutations give rise to autosomal recessive osteopetrosis [MIM:259700]; also called autosomal recessive Albers-Schonberg disease.	18.90	18.90	19.80	19.60	18.40	17.50	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.19	0.70	-5.20	10	112	2009-01-15 18:05:59	2007-07-30 13:35:37	4	3	86	0	64	112	2	211.00	35	74.45	CHANGED	CpcLLtpFusspuchssChshpuhPV.+LCps..ChstYcsLpsh......YsNlpus...........................stpCucslLsSDRlplVsTlpshLss.lWppANC-sCls........pt..shsNcTtpFhshhsphhsChcp..p...........Nto-lCcsCKssYpcLNchYt+l-Kh.........ss..clClDlEDuMNpTRpLWS+TaNCs..Cp-sVs....lIAVuuhlLhLPllFYloSalpocpKc........R+LIhssRhpSssutsslp	....................C.thl.phupttuchhtChspt.uhPs.....plCps..Ch..atphhph......h..ssltps........................pstsCsc.lh..sD+hplVshlp.phhss.hWppAsCssCls.......................................ppt.t.....hoNsThhFhsh..hsphhsChpp...............p................s...............................Nh....oclCpsCcpsYpsLsshYp.chp+.hs.................ss..plClDlEDsMNhTRpLWS+sasCs..pscsVs.....lIAVushlL.hLPllFYloSalpocp+c..........RcLlhspphps..................................................	0	23	27	46
+9610	PF09778	Guanylate_cyc_2		Guanylylate cyclase	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4621)	Family	Members of this family of proteins catalyse the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate.	28.10	28.10	28.40	30.60	26.60	28.00	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.40	0.70	-5.15	10	169	2012-10-10 12:56:15	2007-07-30 13:36:51	4	4	106	0	89	157	9	174.60	40	78.21	CHANGED	VPHlpQtYsWDCGLAClLMVLctlshsspp..t-FpclCpc.thTpSlWTIDLAYLL++FuVcHpYaTpTlGANPsapscoFYK................cphssD.sRVspLFpcAcssGlsVcpRSVohpEIppHLtsGp.lAIlLVsAslLsC-lC....Khsh..shsptsasppscYpGHYVVlCGYDpssscFhYRNPAsSD.+lC....psShcsLEcARKSaGTDEDILLIa	..............................lPhlpQhapWDCGLACshMVL....phh.t..p.t.....phpph.hp......opS.lWTlDLAYLhp......+a............uV..p.apahT.TLG.ss.sYpspoFY+................cphsp-ppRVspLFtpAps.st....l..l.ppp.o....lohp-l..hLhput..hsIsLVstshLp..................p..h......h.....t.hst...p......ssYtGHalVl...pGYstss...tp................h.hpsPu.sc..php....................phs.psh-pARpuaGTDEDllhl........................	0	32	49	66
+9611	PF09779	Ima1_N	DUF2349;	Ima1 N-terminal domain	KOGs, Finn RD, Sammut SJ, Eberhardt R	anon	KOGs (KOG4623)	Family	This domain occurs at the N-terminus of the Schizosaccharomyces pombe inner nuclear membrane protein, Ima1. Ima1 interacts with other inner nuclear membrane proteins [1-2].	21.30	21.30	21.30	26.70	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.19	0.71	-3.66	12	204	2009-01-15 18:05:59	2007-07-30 13:37:26	4	4	167	0	144	192	0	120.30	35	19.20	CHANGED	lsCaaCspcot.shpst.p.WpC.pCEthNhhsEpG-..pD...Psttpsp.....pshtsssp.ss.p...........sspshFCspC.cNQplhhptLApa..hPss-cspYttY-cch.taR+pLEcpYPplCspCEs+V	....................................lsCaaCspp......o.hhsh..t..spsp.apCspC-thNhhpcsG-..ps...Psth.pph.sp.hs.ps.....s...s...tsssp..tt...................ssspslhCpp..CpcsQplhhppLAs..a..h.P.c.s.-s....................................pa-cclpsY++pLEppY..plCpsCpstV.............	0	46	68	110
+9613	PF09781	NDUF_B5		NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4632)	Family	Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol [1][2].	25.00	25.00	51.20	40.70	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.26	0.71	-5.01	10	143	2009-01-15 18:05:59	2007-07-30 13:39:22	4	2	98	0	69	136	0	164.40	44	97.25	CHANGED	MAuMSlL.puuAuhsApLsslhpussttsslppslsts+ss.ush.auGsHG++hFsIpPS+FYD+RFLcLL+FYlhLTuIPVushITaVNVFIGpAELAEIPEGYhPEHWEYYKHPITRWIAR.laDSPpK-YEKhLAhlphEsEKA-hRhhEtEVR+hM+ERGDGPWYaYcT.......l-KEhlDcu.KATPDs	................................................................................h..........th....p....t......h..s...tu.HG++hFhI+P.Sp.a..c+FhcLh+FYlh.LssIPVshhlohlNlFl.GpAELAEI.P................EGYhPcH.WEYaKHPIoRWIARhhasSPpcpYE+thAhlphEsEKAcl...RhhEhcVR+hMppRsDh.haaYps........lsKphhDp..c........................................	0	19	25	47
+9614	PF09782	NDUF_B6		NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4633)	Family	Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol [1].	25.00	25.00	31.50	28.10	21.50	21.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.03	0.71	-4.37	11	120	2009-09-11 15:31:47	2007-07-30 13:40:18	4	5	86	0	65	126	0	126.40	38	83.66	CHANGED	hoGhpP...............DE+lRLptL....RphR+pWLKDQELSs+EPVlsP....cphsPIc+Fapp.L-p......pssathhhhpsYRhslhplshlLlshahsHYYhKYcss......ppsatllppKsplhPG.......sslhEpG.s.Ps.t-assppa	.................hsGhpP...............-E+lRl.pt.l....RphR+pWLKDQELSs+EPVlsP.......pths.Plc....+Fapt.Lc..p.........pssat...h...hh.htshptshhthhhhLlssahhaYYhKYphs......................ppsa.tllpp+.tlhPG.......spl.-pu....s..t-h........................	0	19	24	49
+9615	PF09783	Vac_ImportDeg		Vacuolar import and degradation protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG5073)	Family	Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole [1][2].	20.70	20.70	21.50	24.10	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.34	0.71	-4.78	20	333	2009-01-15 18:05:59	2007-07-30 13:41:13	4	8	229	0	222	328	0	167.60	39	52.54	CHANGED	saLcsGspFpGpQpS.............ppppYpVcVpIcsVDht.........psaLsGaLpIpsLTs.paP....plTTaFEGEIIs.....................scasFhTp.......cWsAsp.........csDlpHWt+FPuF.+slsptttp.......................................tphpht-h.spcalFMRWK.EpFLVPD........tpl.cslsGASa-GFYYIsasp.....ssGsIpGaYYHts.uEpF..QpLpLpss.p.c	...........................hLhsGtpFtGpQpS.............ctptapVpVpl...ppVDht......................puaLsGaLcI.....pGLT-..caP.................slTTaFEGEIIs.............................pcas..FhTp.......pWsAsp..................................csDhpHWs+F..uF.pt.htpph.p.p.............................................................................................sshp....hpchh..sp.palFM..........R....WK..E.p.F..LVPD........................ppl.+slsGASasGFYYICapp........................ssGslpG.hYYa..p.Scha..QpLpLp.s.sp........................	0	65	115	176
+9616	PF09784	L31		Mitochondrial ribosomal protein L31	Mistry J, Wood V	anon	Pfam-B_24102 (release 21.0)	Family	This is a family of mitochondrial ribosomal proteins.  L31 is essential for mitochondrial function in yeast [2].	20.50	20.50	20.50	31.50	19.30	20.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.54	0.72	-3.95	10	125	2009-01-15 18:05:59	2007-07-30 13:41:43	4	3	122	0	100	120	0	106.30	53	91.26	CHANGED	TpPlhGGLLWKlPWRhSssQKtRQRcRLRuVD-VlcsLs................puLp.h+.sp..spppl.+hlsp...hPpEppMSPKDK.......................YTsFsKKs.....+GYRKGIHKVPKWT+lShRcNPptF	............Tssl.GGLLWKI..P..WRLSshQKsRQRcRLRsVDpVlcsls.......................pAL.t...+p....Gt......stcslpRh..htc...hP+EpEMhPKDK.......................YThFD+Kp.....KpYRKGIH...........KlPKWT+lStRhNP.GF..............	0	26	57	86
+9617	PF09785	Prp31_C		Prp31 C terminal domain	Mistry J, Wood V	anon	Pfam-B_7665 (release 21.0)	Family	This is the C terminal domain of the pre-mRNA processing factor Prp31.  Prp31 is required for U4/U6.U5 tri-snRNP formation [2]. In humans this protein has been linked to autosomal dominant retinitis pigmentosa [2][3].	25.20	25.20	28.20	30.90	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.74	0.71	-3.69	28	315	2009-01-15 18:05:59	2007-07-30 13:43:11	4	7	273	0	230	308	5	129.70	42	25.27	CHANGED	ss+hsKsLPhPp-.pspKKRGGRRhRKhKE+auhTEhRKhtNRMpFG....................ppE-shh..hspshGlGMlupssst.........+lR.....htphss+.........sps+hoKph...........................pppLpp.pstss..............GhsSSlsFTPhQGlEllsP	.....PsKtsKsLPsPt-.ts.+K..KRGGRRhRKhKE+.huhTElRKttNRMsFG...................c.E--sht..t-hshGlGhlGpsssG.........RlR................ts.plsp+.........o+A+lSKph...............................................pppLpt...pshtssshs..............................uGhuSSlAFTPlQGlEllsP..................................................................	0	78	130	191
+9618	PF09786	CytochromB561_N		Cytochrome B561, N terminal	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4670)	Family	Members of this family are found in the N terminal region of cytochrome B561, as well as in various other putative uncharacterised proteins.	27.30	27.30	29.60	27.60	25.60	24.20	hmmbuild  -o /dev/null HMM SEED	580	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.78	0.70	-6.06	9	196	2009-01-15 18:05:59	2007-07-30 13:43:26	4	6	121	0	107	172	0	407.90	32	88.01	CHANGED	pss...........psPhlspslshphpptppphhLhhsllsl....ulluhlhh-hshpshhsahsl...shahhthslsulluLsslhs......aspaF+hlh..................sp-plshostQppLLu.lcspspt....ssupsspp.stspsphPsssSss.lph.p.shstSstpStSsu.hhosssssthps..ps......................p..u..s...s.uasosl.s.psSsstspht......SPhuhpp.sspcDhhT-p+hL-paLpphcc...phppussspsos..p.t...sousohhstupsssshupslhpp.hph...Ssuss.s+pchshssKchpu.......h-su.Esht+lu.....hsplppapupL..RtWlSpTlLpPLVpcIcoscpph+ppus...sslpIGplu................................lcpL+psA....................t.phps.hhPhLPhlh.aLDshoNQc.......................YLVpRIKELAcGoClssY+WsuGushpGc...........cWspcLPTDSsllhaLFCsYLD...............oQLsspPh.sG....scsFss+YlllsssKPsstp.......stAhslhlss.sP..PpFshla.D++la....sshpsRsNLFcsll.FlahlKscpsGhlcslNLGpSulNILsll-s	...................................................................................................................................................ss.............ltt.h.....t......lhhh...h......hsh..h.c........h.t......h.....h.h..hh..hhsh.hlh.......h.thhh.hh........................t...h.ho..p..hLt.h.............................................h........t.s...t..........................................................................................t................s......................ss....t.....tpth...t-.t.L.phhtt.pp.................p....................ss.hs.........st.ht..h.hh.hph...u.s.....p...pp.............s.cp................ts.-sh.t+ls......hsphppahsph...R.............Wlspsll..Llpclpphst.hpphsh.....pl..pl.G.psu.....................................................................................lppL+thh.............................s.lshl..h..L-hhspp.p.......................YlhpRl+-LupGsChs.sacWstGu...shpsc.........................pWs.pcL.PTDutllhHlFCsYLD....................................upL...sp.P.h..s.........s+sFs.spahh.ps.sc.sshhp...................pp.shh..lh.ss..s..P...P+apllh....p..c...clh.........ph.pGRsNhFcsllhFlahl+ppptGhlttl...slG.uulNlh.lh.............................................................................................	0	39	53	85
+9619	PF09787	Golgin_A5		Golgin subfamily A member 5	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4677)	Family	Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterised: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1 [1].	30.00	30.00	30.20	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.82	0.70	-5.98	16	253	2009-01-15 18:05:59	2007-07-30 13:43:51	4	5	110	0	149	263	0	354.90	25	75.37	CHANGED	-N..................ElspLsQstAollptpptsp-.p............p.s...s....................................psNpusucspKhsscp.........sppssoohpLsutscshspssusps.......pLAslKltLpEhstElcph+ppL-sh.ppcsp.hpscpcsppLppttl......coLp-+Lp-t-sslppcppshpptphtFlc+lschEh.hppLt.t.s.A.R+hscchpchs-hppplclh+ttscspctELhcY+.+Ap+hLQsK-KhIspLKptshhpuhp.t.ss.............hEL-ph+cEppp.p-ElppLptQIpp.h.EhpDhcsctsupscph+cpspclppthtsphoo....-s-.thhppEhtahcEshtpppsshpsRlp-R....psEhQplRspLos+s.psSu.s-lEsRLpsLTpoLlp+QshLE...pLosEKNuLslQhERlpp.L+t.....t.pssssopl.hphls.s-Ds+tR.lPlhhppssh-l.thht+h++AhpsIDshuIRlGhFLRRYPhsRl.lIlYhAlLH.....................hW	..................................................................................................................................................................................................................................................................................................................................................................................t.ht.............p...t..................p..h.................ht.........htt.ptt.hpt.h..............p.h...p.pt....psp.pl.ttt.............................poLpc+hp.h.cttlthp.ptphh.h.....aht+h.......p..h.c....hp.Lt.t.....A.....p.p.hhc..hp....chs-.....p..lchh+h.hcptc.tL.pY+...tph.lps.-ph.hp.LKp.sh................................................h...........tp-.th.p..-phphh.hQ..l.....ph.pphp....p..t.t......p..pp..pphp......htt.........h..pph..hp.pt..p.tsshp.php.+.........................-hphhhp..tlss...ps..p.p...s...p..-......l-........thhpp.hs.............................ls.h.p+pth.hthc+l.p.hp...........ttpts..s..p..h...th....p..s-..s....sc.p..h....shhhp..p.h.....sh...................slDp.h.........R..hsR..llhYh.hlp.................................................................................................................................	0	48	60	105
+9620	PF09788	Tmemb_55A	Transmemb_55A; Tmem55A; 	Transmembrane protein 55A	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4684)	Family	Members of this family catalyse the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate, in the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.	30.00	30.00	30.20	30.10	28.60	27.00	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.16	0.70	-5.25	7	173	2009-01-15 18:05:59	2007-07-30 13:45:18	4	3	87	0	106	163	0	224.80	49	91.93	CHANGED	M.ADs..ERSPLLScspcGs.....s..u.sst.ht......sstP...tshsPhs....ss.h.uE.PPPYoshsSP-ouosPslsCRVCQSlIsl-GKhHQHVVKCslCNEATPIKNsPsGKKYVRCPCNCLLICKsTSQRIACPRP.CKRIINLGPV............p.uPsoPss..QPtGsRVhCGHCusTFLWsEhpspTL......................ARCPHCRKVSSlGptaPR+RslhhhllsllhllsusGLh...........................sGThphAppatGlYsuWshhllLsllsLsRuhYWhsh+lS	...............................................................t...........................................................................................tt.s...............sE.PPPYs.s.........tS.sss..u...uh..PhlsCRVCQuhIsl-GKh+........QHVVKCshCNEATPIKNsPsGKKYVRCPCNCLLICKsoSpRIuCPRP.C+RIINLuPs..........................p.tPhpPt....pP.t.usR.VhCGHCpsTFLas.php.p....o..L.......................A+CP.H..C+.Kl...............SSl....G.p.tasR+RshhhhlluhlhhhhuhG...Ls...........................hGThph.Appat.u.hYsuWshh..hL..lullhLhRuhYahsh+VS...............................................................	0	28	37	70
+9621	PF09789	DUF2353		Uncharacterized coiled-coil protein (DUF2353)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4687)	Family	Members of this family of uncharacterised proteins have no known function.	30.00	30.00	30.00	30.90	29.50	28.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.23	0.70	-5.17	4	117	2009-01-15 18:05:59	2007-07-30 13:45:48	4	2	80	0	70	102	0	264.50	45	66.32	CHANGED	+pKLpSKs-ALhILtp-LEpsppERDtaKhhscpLp.chpshK+p.pEhph.shttGc..h..tp.............................+ppsLupLlpcsR-cNppLss-hp-L+pphtElptDhclLRpslsc.csuhpthsspcph...........cp+pcLlppL...E+h+cKsptLEpDl+SlhDEKp-VshERDtappKupRLNsELsalLsuDpp..Rll.DlDuLlhENRY.+p+lspLcEEhphh+tslsKYKshhEs.Kpppshl....KsG...ssspsuVhutKQV+-LLtSctsc...thslpstohS-L+uLssuLL-sls-KshALtHQ+psNKlLGsRlsELEpKltsL	.........................................................M.AppLp.RapsLK+p.p-h........ts.......p.............................ppssLupLLp-op-cN+pLspElcpLpQRLsElQGDsK.....LLRhTlA+p..+lsc..p.pl.u.s+..phs...................tHERE-LVpQL......E+h+cphcpLcaDLpuslDEhp-lppERssYpsKscRL...NpEL...salL......uGccs............RIl.DlDALhhENR...YLpERlpplpEElpLhKpslsKYKs.hL-t.K...pp..Ks.h..........................K.t...soshssV.LSsKQV.....pplL.Spt.t...sLPhpspoloDLKSLssALLEslp-KNhslpHQ+pTNK.ILus+lsELEp+lptL...................	0	19	25	50
+9622	PF09790	Hyccin		Hyccin	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4688)	Family	Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterised by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs [1][2].	25.00	25.00	26.80	25.20	23.00	23.70	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.93	0.70	-5.57	12	234	2009-01-15 18:05:59	2007-07-30 13:46:59	4	4	110	0	141	211	0	266.40	36	61.63	CHANGED	spsphsshAssLppctulssAlapllpc..stu-Ll-PlC+QLa-hYpSsE.pLphFsLQFlP.LlahYLptssucc.p...usushEAlLLulYNhEl......sccGsuKllohpIPsLSpPSlYHEPps...hsho-suhtpp......................sh.+sVhSush.pp-slpAQNRhcllshLLhsYNupls.MPtsShhp.lCphsuplsspGa..........................tpt.h.......Rl.lsspFhlp.hpuhaaAhhNG.hshu.psl-slh.RAphEhhscslLluNuhctSL.tuu.spsc-Gphsl.hElp.ss.R....IsppslTuhSlRs++hpcc	..............................................s..sph.phAtsLhpctsl.h..s.ulapslpp..............sts...cLl.-PlC+QLa-hYR.S...u-...pLpp..FsLQFLPtLhasYLthssucshp.....................Ssu...slEAlLLulYN...hElh........................cccG..p..s...KsloFplPoLSp..PS.lYH.E...Ppsh.....hshT-sshtpc......................sh.+s..Vh.Sssh..pp-thsApN.RhcllshLhhsYNu.tlshMPssSh.s.lCphso...pl.sspG...a................................................................................................................tpp.h...t.....t.ps.Rl..ls.s...tFhlphlpu.l.aa.Ah...a.N.Gthp...hu.psl--l..hhRAphEhhspslL..Vs..NAhcsSL...s.s..tp.sp-.G..t.hslps.t...ls.ss.+....lsps..slTshSh+t++h.cc...................................................................................	0	34	58	95
+9623	PF09791	Oxidored-like		Oxidoreductase-like protein, N-terminal	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4690)	Family	Members of this family are found in the N terminal region of various oxidoreductase like proteins. Their exact function is, as yet, unknown.	20.40	20.40	20.50	20.40	20.00	20.30	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-8.70	0.72	-4.52	26	419	2009-01-15 18:05:59	2007-07-30 13:47:32	4	11	343	0	263	401	6	45.70	35	23.27	CHANGED	+sIAGVsVPs+Pp..EPDNCCMSGClsCVW-hYpDDlc-Wsp+pcpApp+	..............................P..pP....-..P..s..s..CChSG..C.s.s.CVa-hYt--L.pcaptthtth...t............	0	75	132	207
+9624	PF09792	But2	DUF2295; 	Ubiquitin 3 binding protein But2 C-terminal domain	Mistry J, Wood V	anon	Pfam-B_45554 (release 21.0)	Domain	This family is of proteins conserved in yeasts. It binds to Uba3 and is involved in the NEDD8 signalling pathway [1]. This family represents a presumed C-terminal domain.	24.20	24.20	25.00	24.30	23.80	23.50	hmmbuild  --amino -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.79	0.71	-4.43	24	100	2009-09-11 16:53:07	2007-07-30 13:48:38	4	4	66	0	84	103	0	143.10	32	44.30	CHANGED	apFPHLIlPlcSouPspuhGTsasGpVoss......lSoIFNFDlPsu....sucoCoLsFhFPp.cth.susasFsGsGphsFspL...susssssTTasNsPshtpcluphsloP..GssYslso.FsC..PuGp..sluaEMssuGs.TpLsa......FpDasPs	..........................hpaPHLIlPlssssPspAhGTsasu....pVoss..........lSoIFNFDlPsu....sucsCoLsFhFPppp....th.ts..ssasFsG.......s...Gp.....lsFspL........suss.sssT.T.asN.tP.....ss..ppc.h...Gs..h.slsP..Gpuasls......o..FsC...PsGp..sluachsssGs..TpLpaFpshs....................................................	0	26	45	69
+9625	PF09793	AD		Anticodon-binding domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4401)	Domain	This domain of approximately 100 residues is conserved from plants to humans. It is frequently found in association with Lsm domain-containing proteins. It is an anticodon-binding domain of a prolyl-tRNA synthetase, whose PDB structure is available under the identifier 1h4q.	21.70	21.70	25.10	22.70	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.01	0.72	-4.14	29	270	2009-01-15 18:05:59	2007-07-30 14:02:34	4	6	225	0	189	258	2	89.20	31	42.44	CHANGED	sssslslpplppRhppslppt.........pppttphGtuVo.-uQplF-slt+T..hstspWsup....sIlVh-.-VpIssP.Ypsss.sp......sssspuhs...pVpKl	................................................lslpplppRtcp..slcpt.............pppttthu.s.GVS.E..uQplFcslpKT...hs....s+Wpsp....sIlVhc....cVhIssP.Yps-s..sp..........ussssu.ls....+V+Kl.........................	0	63	99	148
+9626	PF09794	Avl9		Transport protein Avl9	Mistry J, Wood V	anon	Pfam-B_12001 (release 21.0)	Family	Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo [1].	21.30	21.30	21.30	21.30	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.35	0.70	-5.98	23	380	2012-10-02 14:18:06	2007-07-30 14:08:51	4	13	238	0	281	533	2	300.40	27	50.61	CHANGED	lhtlsVVDFHHp+GP.................clEahas.......tpspttsshWp.LPF.ALPDGuHsapE-FoaFsLh...................ssspstpTlFGlSCsRQIcuscL....hpRssDVTRSTVQKAVVVlucpP.IFG.l+-KLSllTpAaFtQcDFospcILcpha-sLpsp.hpshsspp......................tpsc.........halGL..sLRcllh+FR+phLlLaKhlLL-KKllhau.ssVEtLsshQhullSLlPsLlsp.LpDsu.......................................................................................................sPhhcshcps..lspssShcoSsRpS................................................hLcahGhPLpIFs..................+GuhasPYhPLQQlchL......ss.ss+uallGoSNsLhhpQ+cph.sDlll..........slDssplphh...sspLcphLpLSstD++ahDhllppVppshc-sp.pt............ta....................GS--aIRhQFE-YLhuLLSos	......................................................................................................hlhlVsFchthG..................tlEh.as.................tt.....pthp.lsahAhPDu.sHs..................t-..-.h..a.F.pL............................................................................s..t.ts.ttsl..aG...h.u..C..hR..Q...lc.s.p..tL.........h.+...-...lT.R.uhV.Q.K...u.lsl.....l.........uc..h...P..ha..uh...l.........p............t+Lp..l.lsp.s.aFtp.....t.........ph..t.p.h............p.l..l..h.pth.............................................................................................................hhsh....s..p.ph...l............p...ap..p.h....l.hl.hKhh...hLp.+h..................hh..h.......h......t...........h.......s.h..shh...ShhPt.hh....h.................................................................................................................................................................................................................................................................................................................................................................................t.hth.Ph.lF.t..................p.s.h.h.PYh.sL..hp.l...............................h....ahhGso.N.lh.....pptp....-hhl..........phc......t......t.......l.h.....p.tht..h.....o..Dh+a.hp........lht..h.....t...................................................Gu-talR.pht.Yh.thlt................................................................................................................................	1	105	148	233
+9627	PF09795	Atg31		Autophagy-related protein 31	Mistry J, Wood V	anon	Pfam-B_60001 (release 21.0)	Family	Autophagy is an intracellular degradation system that responds to nutrient starvation.  Cis1/Atg31 has been shown to be required for autophagosome formation in Saccharomyces cerevisiae [1].  It interacts with Atg17 [1].	25.00	25.00	92.10	88.90	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.07	0.71	-4.53	5	24	2009-01-15 18:05:59	2007-07-30 14:14:04	4	1	23	0	13	20	0	177.00	53	99.48	CHANGED	MEs...TlTVYD+Nltaphpscc.............hhssht.S.pGuspoMFPTNIKYIFEDDDDplsDss-h......pp.ss-lENVIIV-LDsoGoLENVELISDpYELLSF...p..pL.p.t.ho..pcuNDpsND........................IEL-VlSEF.sDLSss.o+DLuLD-LlKlYspQNcQL+plSDoL	....Mss...TVTVYDKNV+apL.cEN.pp......s..sthsscS+Ss..DGuchAMFPTNIKYIFEDssD-Ll....DooDt.........................splsD.ElENVIIVpLDESGSLEcloLISDQYELLSa...pphSLppNp.+ohsS+u-D.+uND........................IELDVlSQF.sDLSPh.L+DLSLsDLIKLYspQNEQLQhLSNSl.	0	1	5	11
+9628	PF09796	QCR10		Ubiquinol-cytochrome-c reductase complex subunit (QCR10)	Mistry J, Wood V	anon	Manual	Family	The QCR10 family of proteins are a component of the ubiquinol-cytochrome c reductase complex (also known as complex III or cytochrome b-c1 complex).  This complex is located on the inner mitochondrial membrane and it couples electron transfer from ubiquinol to cytochrome.  This subunit (QCR10) is required for stable association of the iron-sulfur protein with the complex [1].	23.80	23.80	23.80	41.70	23.70	21.70	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.87	0.72	-4.31	21	109	2009-01-15 18:05:59	2007-07-30 14:15:48	4	3	105	0	82	110	0	63.60	35	51.33	CHANGED	paushohpshp......pausthuhaGuuAushshhFhutlP+h+pDlhpKlPhhGsaa.p+pIsPEDsPh	............huulohpphh......pausthuhaGuuAuhsslhFhuslP+lpcDlLpKIPllG....p.aa.p+pl.sPEDsP......	0	19	44	72
+9629	PF09797	NatB_MDM20		N-acetyltransferase B complex (NatB) non catalytic subunit	Mistry J, Wood V	anon	Pfam-B_12009 (release 21.0)	Family	This is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). The NatB complex catalyses the acetylation of the amino-terminal methionine residue of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met.  In Saccharomyces cerevisiae this subunit is called MDM20 and in Schizosaccharomyces pombe it is called Arm1.  NatB acetylates the Tpm1 protein and regulates and tropomyocin-actin interactions.  This subunit is required by the NatB complex for the N-terminal acetylation of Tpm1 [1].	22.80	22.80	23.00	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	365	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.08	0.70	-5.74	41	303	2009-01-15 18:05:59	2007-07-30 14:19:52	4	15	265	0	219	313	2	352.20	20	40.32	CHANGED	Wshaphhl......pushpl..................ppppsshtphp.h.p.ltt..................t.hsRsshLApL-lhthh..................ptpchtstlhp...YaccFtsKssCasDLppYl...tl....stp.phpphhpth.pt..........................ss.pphhpplsshcl....................................t..tthsppph.p........hhpphhptappshpht.pt...............p-hpsuD.chsLlusp.hllch..............pppts.phllpulslLEphlscsspNaphpLhLlplYhhL.GssshAhptappLslKplQh-TluHhlhsphsshtshstss............phhspshpaYpsspppssch.ltpuactssaspl.shhcFpc+LppShp+...hhhtl-phplptlh.ssphht....thpthsp................p..stpslsDsRDh	.................................................................................................................................................................atha..hh......tushph.............................t.t.pt.p.thp.h..p....l.p.......................tt.hhRsshLApL....Elhpphht.t............................p.ssh....phhhp...YapcFss.KssCasDLchal...thL........s.p...phpph.hpp.lht.h....................................tshpth.pplsshpl..................................thhh.s.......t..p..hs.tpph.p....................hhpphhtt.appshphs.ps...............p-h.p.sD.thsLlAsp.sLlchh......................tpsss.sh......l..hpAlslLEp.h..L..ppo..spNhph+LlLl+lY..th..L.Gshshuhp..ha.ppLclKplQhDol.u..ahlhsh...htshs.hstss.......................................phhpt.h......hp...aa.psstp.cssch...lhtuachssasp..........l.chhpa.pp.+LppShph.......hhsthEphhhphhh.tsp..t.........hpth...........................p.th.Dpcs.....................................................................................	0	82	125	183
+9630	PF09798	LCD1		DNA damage checkpoint protein	Mistry J, Wood V	anon	Pfam-B_41058 (release 21.0)	Family	This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1 [1].	25.00	25.00	38.80	31.40	18.30	22.00	hmmbuild  -o /dev/null HMM SEED	654	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.99	0.70	-12.96	0.70	-6.53	6	47	2009-01-15 18:05:59	2007-07-30 14:21:43	4	2	43	0	29	43	0	601.70	32	89.65	CHANGED	MLRD+.................LphLppptcc-csppptphsplpscacpELpKL+ppLQ+LEDE+KFLlhEpRulssschps.....p.........p.h.ss-ussls.pupssus+p++cchp....hpphlsLs.s+llt..c-sSLFhD+lh.apIhGu-hosl-hLs+Iph-h.s-hss.cphlIsustPLGpuIpphLhphKpphpLDchVDpsLEsLAsLIKp.Ilhsp-spLulPFLlALMapslpFRsSAsSlpuLKDLF.FhsDLhhpFphlLKsPlHcSs.L-lclsPplFQYpllDpLsLhYSFDllEsshpl..l.ppssps.pphacE.hlhKsLhtshphsLTISaKsl..lNlIaShVEllhslssl...h..pssscslhssphWtslIo+Laplhp+plpsscla........hph..hhsFhGLpRshGsNssssLIcplIsppcl..........pulP........hlIp+-s.shst-s.....h...p.chEtWhlpL+pslssIhcpLlhpapcp.plsstEhLhphs+hlupEQthhhshhlstDopshthRhpLlphLlplIYhhWppapcplppphhh-sps.ELlhsLWRllasp.psps.tpp..h-hthLlsphcsLslcDppcha-Dsa--.sh.PtalcpELtsphsppstpthpspa-phhhEMA+pILES....hlohEEsDSLYluM	.................................hLRsp.................lp.Lptp+ccEhph.ttphpphphpc........pclstLKpplQ+LEDEKKFLp.Eh+stoppcht..p.....p.................tsh.sssspss..s....pspsp.......osps+p.pchp........tpshhsls.s+ll...c-oSLFh-plh.HpIhGuchoTlEhLs+lpl-.hschph...cshhIsKttslupuIsphLht.hKKshpLDchI-phlpslssLIcc..lp.p..-spLAVPFLluLhapslpFRPSAspp.sl+chhhhlCDLlphapalL+s....slc-ss..hshcstPp.hQhpll-hhllhauhDlLEtllpl..hppastphhhphacc...lhpsh.hshh.s.o.paKsh..lNVlashVEllsh.soh.........shs.s...ss.pphhstp...shIspLhtlh.h-l.st-sa........................................sFaGL.RslGsNp.sthIsplI.p-ch..........pulP................plI.c-s...hspsp.................lshphEtaLLpL+.clhslh-sLlhhhts.thlhstEhlhphs+hluhEQshhhp...u.cS.slclRhpLIpphlplIahlhp-p.cplpp..hp...-s..t.-LhhsLhRlhhspspts..........ss.s.cp.hh-h...Rph.sthppL.slp-p..sphhpcthpch....spahp...t...Ehhtplppchuphhph.Y-pch.EhARpIL-s....hsohEEADsLYhsM............	0	6	16	27
+9631	PF09799	Transmemb_17	Transmemb_17; Tmem17; 	Predicted membrane protein	KOGs, Finn RD, Sammut SJ, Coggill PC	anon	KOGs (KOG4694), (KOG4502)	Family	This is a 100 amino acid region of a family of proteins conserved from nematodes to humans. It is predicted to be a transmembrane region but its function is not known.	23.30	23.30	23.60	23.80	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.24	0.72	-3.72	24	272	2009-09-11 14:19:48	2007-07-30 14:25:56	4	2	110	0	190	264	1	103.40	28	63.14	CHANGED	hhLYhsshahshaalspllhhhhK......hhhhsshhhshtlshhllhsllEslRLhlGhtGNLpEcsstLshhhlLohhstlshlhahhhpshlLh..L-hslsslhlshhsh	.........................hhhahNshahshahlsplhhhh.hK.......h..h..h.s...s.h.h.....h.........hh.tlsl....lllhhllEslRLahGhp.GNL.s.......Echs.Lsh.lhLThsstl.h.slaaL.L.h.p..shlLp.....lEhhlsslhlhhhh.h..........................	1	55	75	129
+9633	PF09801	SYS1		Integral membrane protein S linking to the trans Golgi network	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4697)	Family	Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1) [1]. Sys1p is a small integral membrane protein with four predicted transmembrane domains that localises to the Trans Golgi network TGN in yeast and human cells [2].	21.90	21.90	23.30	22.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.77	0.71	-4.19	27	331	2009-01-15 18:05:59	2007-07-30 14:27:17	4	3	259	0	233	308	3	132.70	30	71.10	CHANGED	apps.hsPhhIlsQIlhLQshYYhshsllh.hhhstlsG.sho................L.-hlFsac............slchssshGhhlhhhalls.uLl................sslhLhhlVtRoKLsLDFAlTlHhlHLlhshlYo...pshPtshsWWhlplhusslhshlGpahChh+EL+sI.h	...............................................................................hsPhhIltQIl.hh.Qsh.aYhsh.slhh.hhhshl.hst.t.h.o...................l.chlFsa.c.................................l.ph..ss.s.Ghhhh.h...s.al.Ls.ulh................su.lh...Lh.h.llpRuKhshDFulTlHhlHLlhshhYs...tph.PsshtWWhlphsuhslhshlGpahCh.h.pELptI.h...........................	0	78	126	188
+9634	PF09802	Sec66		Preprotein translocase subunit Sec66	KOGs, Finn RD, Coggill PC, Sammut SJ	anon	KOGs (KOG4699)	Family	Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures [1][2][3][4].	21.30	21.30	21.40	21.40	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.03	0.71	-4.90	16	149	2009-01-15 18:05:59	2007-07-30 14:29:02	4	2	146	0	113	141	0	182.10	37	76.09	CHANGED	hphlSlhTPLlYlulLlsSLhsFSshYRK++hpchupLcPhFs-ptsRclYhsLtch.-s.........................+lp-KVlKAALLRRusEsIRRslKL+EtcstlshLappGSlGDDlWpRFppttKhhEhEl+-llpEApshtPsWsQohFtsApEIshNpALRRRhssIpsRscpptchW-h+hs..psuhhhp	.................................................h..hlSlhhPhhYlslLluoLhsFSshYRKR+stc........sp.l.tPaFss.ph..p....RslYhoLhchp.............................pls-pV..LKAALLRRAsEDI+R...llcl+ptKsulstLhQ+GSlG.DDlWpRFppAEKEhEtEl+DVltEANsht...P..uWGQhIFpoApEhsh.Np...hhRc+lpplppptppppchW-h+ts..pp.............................................	0	35	64	98
+9635	PF09803	DUF2346		Uncharacterized conserved protein (DUF2346)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4702)	Family	Members of this family of proteins have no known function.	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.73	0.72	-4.13	6	116	2009-01-15 18:05:59	2007-07-30 14:29:41	4	3	106	0	83	121	0	77.40	29	84.11	CHANGED	MGsWtLEluRMslYhTFPVAMFalFNQPEYFE-aVscpKRplaPPEpcpHRcclEchhcpl.....R-++-pcLL+thp.tEpKc	.........MGs.pLElhKhulYlsFPlu.haa.h..h..Nps-hF...c..c...a.lh.....p........p+cc.la.PP.Epp.........p..t..........c..pElp..c...htc.ch.....ppp..cc.pchhcth.......ptt.....................................................	0	34	46	65
+9636	PF09804	DUF2347		Uncharacterized conserved protein (DUF2347)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4704)	Family	Members of this family of hypothetical proteins have no known function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.87	0.70	-5.13	36	201	2012-10-02 14:18:06	2007-07-30 14:30:16	4	7	172	0	144	318	1	266.40	32	54.98	CHANGED	lFllpFDlKsGYslsWpcsh...sslpL-G.VEYKoLPSGlHpls-DllY.Fs........cc.ta.....hGlSsFhstsss.-ppR........ss+MhulGVLss.................s.thlspuWcasstLcphs.pphhpst....sshpsLppaa.....p..ph....tt..............................pttshspstshhsspphhsshHPshsLPphlcphGPLlFsLa+uuLLRKRILlh....sps.................PVctsCsa................VYslSlLSslPpslhshhssp....s.h.pPlFslGlpDl...shLtph........................uaIACToDpILthKscLaDlhVslssststpstt	............................................................................................................................................lFlhpFDh+.t.G.hl.Wp....hs...........s.....ls....L....-......G..V..Ea...K.....ShPS.....GhHplppDhlY.Fh................................cs..a.hGlusFhshss-.ctpR..........sA+MhuV..G.lLss..............................hsthaRahp.hLcphs.pphhps...........sphp..Lp...taa...........cp.ph..............................................................tht.s..h..s..sh..hh...t..ph.p.hHPshshsphlchFGs.IhsLa+.huLLRKRILIh....s.s.................................................PVt..sC.h...............................l.Y.s.h.....s.....hL.us.lshshhshh.sp........................+PhF....lsltDI....s..Lps.h.......................................ualACTT-cIht..KpcL.Y.DlhVshsssho.p.......................................................	0	40	73	111
+9637	PF09805	Nop25		Nucleolar protein 12 (25kDa)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4709)	Family	Members of this family of proteins are part of the yeast nuclear pore complex-associated pre-60S ribosomal subunit [1]. The family functions as a highly conserved exonuclease that is required for the 5'-end maturation of 5.8S and 25S rRNAs, demonstrating that 5'-end processing also has a redundant pathway. Nop25 binds late pre-60S ribosomes, accompanying them from the nucleolus to the nuclear periphery; and there is evidence for both physical and functional links between late 60S subunit processing and export [2].	22.50	22.50	24.90	22.70	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.20	0.71	-4.10	41	300	2009-01-15 18:05:59	2007-07-30 14:30:41	4	6	257	0	202	285	1	141.20	26	58.48	CHANGED	p++phtpp....scElsFDccsRpEaLTGFHKRKhpRpKcAQE.hcc+tR.t+hEERK+lR-ER+pchpctlcphccthp.lpcttsstcctpsspsppspt-...................s.t.......p.sspspptp.hDpcph...................................osVslEpl-s	.................t......pt..thtplsFDccsRpEYLTGFHKRKhpR+.....Kp..Ap-phcc+h+.tphEcR++lR-ER+pp...h.p..c.....hl..p.....p.h...c..ct..h..p....hp...p...t....tsp.pp.......pttpp...p.p.p...............................................p...t.s.s.p.p..-.sth...........................................................................................................................................................	0	67	110	164
+9638	PF09806	CDK2AP		Cyclin-dependent kinase 2-associated protein	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4713)	Family	Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.	25.00	25.00	25.00	26.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.36	0.71	-4.07	11	192	2009-01-15 18:05:59	2007-07-30 14:31:31	4	4	91	2	111	168	0	120.90	43	82.32	CHANGED	MsYhsItss.Sphs.................ssTshPtssht..............................................................................suGSssosS.........................................................................................................................................ss.suuuhhpPlhSshs.PShG...ssssh.......oKYupLLuVIEEMG+-IRPTYuGS+SuhERLKRGIlHARhLVREC...LtETERsARp	................................................................................................................................................................................s.s......................................................................................................................................................................................................................................................................................................................s...ssu.s.h...p.lh....s..c.h.us...PShG.h.sp......sstss.........SKYu-LLulIEEhGK-IRPTYAGS..K..SAhERLKRGIlHARsLVREC...LtETERsAR..................	0	25	34	69
+9639	PF09807	DUF2348		Uncharacterized conserved protein (DUF2348)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4723)	Family	Members of this family of putative uncharacterized proteins have no known function.	31.60	31.60	31.70	31.70	31.50	31.50	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.66	0.70	-5.27	5	176	2009-01-15 18:05:59	2007-07-30 14:31:58	4	4	121	0	114	164	0	204.20	28	87.66	CHANGED	MFPELNsLLssoPDpsE........pGKlTLLCDu.KTDGSFLVHHFLSFYL+..AuCKVCFVALVQSFSHYSIVGQKLGVSLTsAR-+GQLVFLEGLKSul-llFp...su-sspPLpFLREussGsLcsLFcFVp-oL+..PusSuGs.WphPVLlVDDLSVLLS..LGVuAlAVLDFhHYCRATVCoELpGNlVlLVH-sE-AuDE-s-...lLLpGLSHQSHLIL+AEGLATGFC+DVHGQLcILWRpsSsSutpRuQoh..sYQYKIQD	............................................................................................................................up.hhll.p-t..pssuuFllpphLp.hL+............us..s...t.......lhhluh.p.shsHYp.lup+...l....G.hsLshtpc.psplsFl.-sLp.....ht..........h....ht...............t...t.ttsp.........t.hh.....ts.s.........s....t.L...p.La.p..lpptlp.....s.s.s.t.ts.............sslllDDlSlLhs.........hG..h.u...s.h.t....Vl....c...Fh....chsp.sls..h.p.....h..p.s..s..hV..........hLs+......ts.....tp.s.......p.cpst.............lhptLta.uplhlpspsLsTGhspDVcG.plpl.....c..........................................................................................	0	38	55	87
+9640	PF09808	SNAPc_SNAP43		Small nuclear RNA activating complex (SNAPc), subunit SNAP43	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4746)	Family	Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 snRNA TATA box.	25.00	25.00	25.40	25.00	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.25	0.71	-4.63	17	185	2009-01-15 18:05:59	2007-07-30 14:32:26	4	4	132	0	126	174	0	174.70	25	47.41	CHANGED	sl+pDhcpLLpcFtpt....coscFpsFpplWcchp...FpplFpG+ppssEhhtFsptlLhhshtYhhss.........pohppRluuLYhLYslY.pQ.sp.hhKIRlshpsapchpcaspphh....ppphh.-sshlhp+LhpcpAF+FsAh.phhs.shh+ph....p...hptpstpphhsstspspplhp.ph.....lpcLt.lcttYpchK	........................................hppDhctLlpc...Ftph...........pshpFpsFpclWcphp...Ft.tlapu.p...pph-..h..t.pFscphLthsh.p...ah.hss...................................................hohp.RluuLYhLYsLYpsQ........s....ps......h...............hKI+lslcsapplh....ch.pp.hh.......ptphh.-sshlhp+.L.h.p.pAFha...s...Ahs.phhs...t....h.pph.........p.....hh.th.....tph.th.p...t......hpth..hpttYtphp.............................................................	0	43	63	101
+9641	PF09809	MRP-L27	MRP_L27; 	Mitochondrial ribosomal protein L27	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4756)	Family	Members of this family of proteins are components of the mitochondrial ribosome large subunit. They are also involved in apoptosis and cell cycle regulation.	25.00	25.00	25.50	26.30	24.50	24.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.22	0.71	-4.46	16	274	2009-09-11 08:35:56	2007-07-30 14:33:14	4	3	242	0	196	253	1	95.10	31	65.91	CHANGED	+sus++hshToKpGs+sa..hKG.............+GupshGhhspsG+alh.h-hV.palVPs.LpshcLKPYVSapsPplpps................hcsacpGhhcs-hh.chshE.spcG+l	......................................................................................thh.LToKpus+sa..YKG....................psspshGha.s..p.pGpYllshcKl.saVVP-....Ls...sF...+......LKPaVShpssthhpp............................................................................................	0	59	103	160
+9642	PF09810	Exo5	Morph_protein1;	Exonuclease V - a 5' deoxyribonuclease	KOGs, Finn RD, Sammut SJ, Coggill P	anon	KOGs (KOG4760)	Family	Exonuclease V is a monomeric 5' deoxyribonuclease that is localised in the nucleus. It degrades single-stranded, but not double-stranded, DNA from the 5'-end, and the products are dinucleotides, except the 3'-terminal tri- and tetranucleotides, which are not degraded. The initial hydrolytic cut of exonuclease V on the dephosphorylated substrate produces a mixture of dinucleoside monophosphates and trinucleoside diphosphates. The enzyme is processive in action [1]. Exo5 is specific for single-stranded DNA and does not hydrolyze RNA. However, Exo5 has the capacity to slide across 5' double-stranded DNA or 5' RNA sequences and resume cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively [3].	25.00	25.00	25.90	25.30	23.90	24.60	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.10	0.70	-5.20	13	244	2012-10-11 20:44:46	2007-07-30 14:33:33	4	5	193	0	168	260	3	317.10	25	67.42	CHANGED	SPlcRF+p..ppslSVTDLsustWCElQhhYsLsc..hG+KccTtAM+pGsplHcpLEcElassVsVc.....V...TT+EDshuL+lhNhIptLppLpppG.............hsREl.VaGhl.cGpllsGlIDpLshcssc.phppp......p..h..........................................................clhloDsKTRtusolPo..psQhRsohlQL.LYp+hLschss...................................splshpplhscY.......sLDPpcsFossahsp.u.ht.......................................................p..t..hhcapsLpsLhphhhtphphp.LP...........................hlssphphcYcppsssp.....lluscpaha-.cslcthls-thsaW+GpR-scGV.cspEuWKCRhC-Ft-pCsWp	...............................................................................................................th.......phLsVTcL.hs.tWCEhph.Ysh.t..................hh.p....ts.s.........hctGpphHttLEp....Ela.p...ltl...............................l...poc.....E...Dshu..l+...h............h.Nhl.tl.pLhp.pG..................................................hsR..Eh.l..........a..G..hl.....c.................s..................hlsGlIDpL......p...h..p...s..p................................................................................................................................................................plhlsDhKT...R....t..p.........plPs...ps.t.h.c.s.splQl.hY+.hhhsph.sp................................................................tp.hsht.thh...pph.........tLs.sptshs..t..hht.p...............................................................................................................................................................................................................................................................hh.pht....s.L.tp.lhthh...t..hph..hs....................................................................................ht..hthpY..pts...................hspp.h.as.p.lpthlpp.htaWhGpRpspsV.........p-t...h...K...CphCca.tp.C.h...................................................................................................................................................................................	0	50	92	134
+9643	PF09811	Yae1_N		Essential protein Yae1, N terminal	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4774)	Family	Members of this family are found in the N terminal region of the essential protein Yae1. Their exact function has not, as yet, been determined. The family DUF1715, Pfam:PF08215 has now been merged into this family.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-7.90	0.72	-4.42	82	669	2012-10-02 21:03:42	2007-07-30 14:34:13	4	24	410	0	356	588	16	38.90	34	17.48	CHANGED	GYp-GhspGpppshpcGhp.Gapp.Ghp..hGhphGphtGhh	.........GYp-GlspGpppuhp....cGhptGhpp.Ghp..hGhphGthpGh...............	0	93	179	275
+9644	PF09812	MRP-L28	MRP_L28; 	Mitochondrial ribosomal protein L28	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4778)	Family	Members of this family are components of the mitochondrial large ribosomal subunit.  Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S) [1][2].	24.10	24.10	24.20	24.50	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-10.82	0.71	-4.40	14	225	2009-01-15 18:05:59	2007-07-30 14:34:48	4	4	207	0	158	213	0	134.30	24	72.35	CHANGED	hpApPh+KKKKlDP....pppttt+c+lc+plR.+hpKssppLpPl--hhss.p.lcpsppRp.thhclo.E-l-+Rsll.KpWupY+ppp+pt-hphlcphltuQpcALppLch.Ss-LYptAlts-su.hhPhchcsPstoPP............p.o+la	......................................................................................................l+...php.+.t.t....ph........Phtp.h.hs.....h.p...+p.t..lclut..-ch.++thlp+sWslapppp+ctcppplcp.hpu.pcAh-EL+.......t....S...............cLaptA.................t......-.........t...hhPh.p.h.phP...hPP......................................................................	0	48	74	125
+9645	PF09813	Coiled-coil_56		Coiled-coil domain-containing protein 56	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4782)	Family	Members of this family of proteins have no known function.	21.10	21.10	21.10	21.10	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.07	0.72	-4.02	4	119	2009-01-15 18:05:59	2007-07-30 14:35:03	4	6	108	0	85	117	1	85.20	31	62.89	CHANGED	MAt.......osKEGsA.aApRIDPo+EpLoPtQlcFMRplEhtQWpK..pht+hRsRNllTGLuIGulVLGIYGYTFYSVuQE+FLDEhE--AKAARt.uh.hppss	.................................tt...h.............................................t.hp...php+........th.t.h.R..t+NhlTGLuluu.lVluIY.......uYThhuVpQEcFhD.....-.h..-c.hph............st.....................	0	21	38	62
+9646	PF09814	HECT_2	DUF2351;	HECT-like Ubiquitin-conjugating enzyme (E2)-binding	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4784)	Family	HECT_2 is a family of UbcH10-binding proteins.	19.00	19.00	19.10	19.20	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.32	0.70	-5.73	28	316	2012-10-03 14:42:41	2007-07-30 14:35:36	4	9	236	0	227	300	2	298.30	16	76.93	CHANGED	Ehhsplpshplhlphsspht........sls.sphplplsps....................shplpLPsclphsspshhththtst.............slphclplpptsss....................thsspslpsps........hplhCpsCppsllps........pshp................+lh-hPSEtWsphhD.WaCHpss.tstptt..............................ppLpPpps-.lhlGssahL..lppsphpphhhhtt...................t.lhCppCps.LG..........phsspsh+LaKhslph................t.ss..cph..pphlhtpllphlpspusc.............+Fhlpt..........sspphl.....hlWlhssshtlsp....stt...........................................tsspsuhKlLYp.......t..thhshhpss.slcplplP...stshpphhphLppsNshlPtshR..thss........aplu	.........................................................................................................................................................................................h...............................h.h....h...............................hthth.h.t.........................................h.tpphpstp..............phhCppCtp.l..lpp........pph......................phhsLPStpW...tth..h.-.W....t.......CH.ss.tp..........................................ptlhs.ptsp.hh....lu.shhl..hp..pssh.p.t....................................................................................lhC.....t.pCt..lG..................................tt...tshcha.hhtl.h............................pp........pthhst.llph.ptpssh.................+hhlps....................ttp..l........h.lWlhssp.h.hh........s..........................................................................................................................t..tuhKlhYp........................t...............tht.....l..h.......h.thh..lttsp...hP.t.p.........................................................................................................................................	0	65	116	185
+9647	PF09815	XK-related		XK-related protein	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4790)	Family	Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems [1][2].	20.20	20.20	20.40	20.30	19.60	19.70	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.30	0.70	-5.44	35	705	2009-01-15 18:05:59	2007-07-30 14:36:05	4	12	97	0	433	583	1	269.20	23	65.58	CHANGED	c...hhhslhulhhahsDhusDlaluspYatpucahatuLsLsFlllsSlllQhhSahWappDhspsphp...............................................................................h.hhsllHlLQlGhhhRahcslphuhpsthpppppp............................hpthhhtpsDl...oMLRLlEoFLEosPQLlLQLaIhl...............................tp....ps..phhQhluhshShhSluWullsYp+s......LRtphsDKpphsh.husllhhlW+lhhI......................suRllulsLFuulhthasshhhhhhWllhh......hWshtpp.Ts.Ftp.ohshEhlaphlVGllhlFsaFN................VccupTRtRhhlYYshhll-slllhhl.h.....hhh+sshhsp.htlhlsssl....hssahlGlhhhllYYphhHPs	............................................................hhsh...h.p...thhh......ah..tt..p........h.h.hhsh.h...h...hhsshhhp...h.s.h..........ah...h...s.t..t.t.............................................................................................h.hph..h....h.u...h..h.........R......h..hpshhhhh......p..........ttt...............................hhhh..hp...ssh...shhplhpsaL.tos.PQLhLQlhlhl....................................................tp......tth.......hthh.hh.hShh.ulsashhthphh..............lp......hs...s....h........h...sh...huhl...h.hh.W+hh...l......................ssRhlsh.sLF.sshh....hhhhhh.hhhpahhhh................hWh..hhtt...sp....ht..............s...........h..................t.................hhh..h.lh.uhlhl.ash.hN.................................l.pcs.p.st..h+hhhaYh..............hhhhENhhhhhh.a..................h..h.t........................h.............................hhh.l....h.sahh.u.l.....hhhllaYt...hhHP..............................................	0	122	154	274
+9648	PF09816	EAF		RNA polymerase II transcription elongation factor	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4795)	Domain	Members of this family act as transcriptional transactivators of ELL and ELL2 elongation activities [1][2][3][4]. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. The N-terminus of approx 120 residues is globular and highly conserved [5].	20.20	20.20	21.40	20.70	19.40	17.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.68	0.72	-4.09	29	307	2009-01-15 18:05:59	2007-07-30 14:37:57	4	8	211	0	216	291	0	104.00	31	29.65	CHANGED	pYslhLGsphp.............scssps.....phhsl+YsFKPsSssssp..splpts.....pspphslsl................sssuspss..hsacGs..........spss..pppchlLlF...........DscspsahLE+lsosl.phphpRsss	....................aslpLGpohp........................cpsps.........tFpolRY..-FKPAS.lDsopt...uplpsu.........pssplslol.................phpuus..ss..slFcGs.......................p+sh..p...c-slLlh...........stc..otthhLE+Lsosl.pl++sRs..s.......................	0	60	99	156
+9649	PF09817	DUF2352		Uncharacterized conserved protein (DUF2352)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4803)	Family	Members of this family of uncharacterised proteins have no known function.	25.00	25.00	25.40	25.30	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.95	0.70	-6.34	9	120	2009-01-15 18:05:59	2007-07-30 14:38:32	4	4	80	2	74	113	0	412.90	28	87.48	CHANGED	PspYhsslpst............h..tsp....schlalhc............................pspL-hpssshc-sh.pp.suls-........LSlcp.ht....................tslslt+ARpllshhpht+s..shu............slWlhCDGSD.ptTshLthEhst....psphhpGllhahssps......sh.hohpsLtppHpp+tt.uh.pspthuh.pha..........pspsplTlcloWssssp.....hLppsslu.stTlplc.t.h-ppuss.pphappLcFLlslt-slhohcsEhhpshpscus..ss.sph.ls-Lcpclsphhssssc.pspphspssst...tsh.phlpsRtshDhs-pLWshh+p.ssSYpDLptsFshlhQshp+usIts..pssssopLucLIpp.hpschshssLoGspPhchLLEIGL-KlhKDYhshFsppclsohNhLchhh..............................................................sophDtpEpshRlpKLaplhplL...pphLhlchphclh.haopsC.cYh+csPhs.pcla.......pl.lpsphlpchhpsccPhph+VphsSspt....+cVcTsa.hsscs.ls......schs.phpssspp.....ccthahhphlpspp	............................................................................................................................................................................................................t...................................slsh.pu+tl..ht....hhtps..shs.............slWhhCDuoD...tt.ThhLthph........sp.h..pGl.hhh.ssh.........t...p.p.tlhp.....a.tth..s..t..th...phh.................s.sth.lchpWts.st..................hp.ss.......tthhplt.......-.ps.h..thhppL....phLhhl...tcslh.shhp-h....sh....pt.psh........ht....t..hs.cL.pphp...t..........h.sphpt...t....h..tp.........th....h......Rt.hDhs-pLWphhpp..s.oap-lh......sh.phlhpshtpup.lts.hp.s.spshLuplIpp............hpt.pht..............s.LsGh.......PlphLlElGl-Klh+DYh.h.......ah.t.pchsshs..Lp.h......................................................................................ssth..s.pcth.+l...t+Ltplhthl...pph...hhp.thph....hs.p.s..phhpp..h..p.h...............pl.l.......th.l.....pp..h.hptppP..h.phph.st.........ppl.T.sh.hs.p..h.............t................................................................................................................................................................................	0	21	27	51
+9650	PF09818	ABC_ATPase		Predicted ATPase of the ABC class	COGs, Finn RD, Sammut SJ	anon	COGs (COG3044)	Family	Members of this family include various bacterial predicted ABC class ATPases.	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.29	0.70	-5.90	44	462	2012-10-05 12:31:09	2007-07-30 14:40:15	4	4	429	0	135	1778	323	421.10	45	75.58	CHANGED	hppLpphLpplDs+sYtAYKplpGp.Ypas.....p...apLhlD+VQuDPFAsPScl+ltlstshs..................shstthh..psts+plAhpDals...Rphtpth...........thtssscoGhltlspsGQplLcRoushl...........................ssptl...clRhpVuLP....ApGRcIhu+tAhplLhptLPcllccslhhpth......stcplppalphscDQptLRppLtc.......tGLVAFVAsGuILPRcSGsS-+......Phc..sAVPFpSPc....oLc.lplpLPp.tGplpGMGIPcG.lTLIVGGGaHGKSTLLcALEpGVYsHlPGDGREaVlTcssAlKIRAEDGRslpsVDISsFIssLP..tGcDTs.pFoTpsASGSTSQAAslhEAlEsG..............upsLLIDEDTSATNFMlRDtRMQpLls+ccEPITPFl-+l+pLhcchGlSTllVs.GGSGsYhclADpVIhM-sYpstDlTtc.......A+clspp....hsstpttpstt.........sR	...............................................................................................................................h.ppLhphLppl-tpsYtAY+plcGp.....YcFs...................s........apLhIDHlQuDPaAsP.S+l+shhshphs.................................................sh....s......hh.....ps.ht.phA.hpDals...RtFtphh..........................t.....t........psutlpIstsGQplL-..RTulhh........................................spctl.........ElRhcluLP...............ApGR...sIh.u+pAtplLhptLPchlccuhhhc.pl.............stptLhppsclsEDQchlRppLpc.........................tsLVAFVAsGulLPRpoGssDh......Phc......sAVsFpo..Pc.......oLc..lshphPs....t........Gpl..p..G...M..G..I..Pc....G.ITLIVGGGaHGKSTLLpAL...Ep...GV...Ys...H....IsGDGREaVlTcssAhKIRAED.G..Rs.l.p.s.l.sI...SsFIspLP........hG.+.......DTs..pFS.T.p....s.A...SGSTSQA..AslhEu.lEuG......................................ussLLIDEDTSA.....T...N....F....MIRD...tRMQtLlu.+..pc..E...PI....TPhl..-RlppLh..cch....Gl.S.T.llVh..GGSGDYhD.V..A..DsVI..Mcs..YpshDV.TpcA+clstp.hsp.ct.t...................................................................................	2	67	107	127
+9651	PF09819	ABC_cobalt		ABC-type cobalt transport system, permease component	COGs, Finn RD, Sammut SJ	anon	COGs (COG4721)	Family	Members of this family of prokaryotic proteins include various hypothetical proteins as well as ABC-type cobalt transport systems.	20.80	20.80	21.30	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.69	0.71	-4.19	51	1105	2009-01-15 18:05:59	2007-07-30 14:41:44	4	2	991	0	157	535	10	127.90	35	65.84	CHANGED	lhDIllsulluVshGlla.hsashlhsslsshhs...hsPhhpsl.................hhGlWhhuusluuhllRKPGAAlluEhlAAhlEhllGupaGst.slltGllQGLGuElsFA..lhtY++ashhshhLuuhsuulsshlh-	...........................................pDlllhuhlulhFGlla.hshshl.Y.shlpshht...htshhppl..................hhGlW...h.MAAslAulll.KPGuAlluEllAAhs.Esl.h..G..u..paG.ls.slluGll.QGLusElsFh..lh+Y.+.phshhshhluuhssslsuFsh...........	0	45	96	131
+9652	PF09820	AAA-ATPase_like		Predicted AAA-ATPase	Mistry J	anon	Pfam-B_5377 (release 16.0)	Family	This family contains many hypothetical bacterial proteins.  This family was previously the N-terminal part of the Pfam DUF1703 (Pfam:PF08011) family before it was split into two.  This region is predicted to be an AAA-ATPase domain [1].	26.10	26.10	26.10	26.10	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.03	0.70	-5.24	84	1607	2012-10-05 12:31:09	2007-07-30 14:44:05	4	10	265	0	256	1536	96	241.50	31	54.30	CHANGED	PIGIQsFcclRpcs...YhYVDKTthIhpLhpsusha.FLSRPRRFGKSLhlSTLcsaFp.....Gp+cLFpGLhIcc.pp.........tW....tpYPVl+lshsstph.pohppLpptlpphlpphtptashthp.............................cpshssphttlIcphhcppGppVVlLIDEYD+PlLpslp.st......p...........hhcchRp...hL+sFYuslKs....t-saL+FshLTGVoKFupsulFSsLNNLpsIohsp..pYsslCGhT-pElcphhp..hpths.....shcthhpcl+chYDGYpFs..s.....slYNPFslL.hhpp	.......................................PlGlpsFpcl..h...pps.ahYlDKTt...h...l.........p....l...........h....p....p...s..p....h...hhoRPRRFG.K.oLhhoh...Lc...taFp...............................tpccLF.p....s....Lh..I.tp.....p..........................h......s......pY..PVlh...ls.hp..shph..tsh...p..p....h.p.lpth.lp.th.p..ath.hp.........................................ptshttphttlhphh.hpp.h.s.pplllLlDEYDpPh.ps.ht.pt................................hhpphhp..........hh+.s.h.a.sshhp......tsthlc..hshlTGl.+h...s..p........ulF......Ss.......LNp.h..p.s..h....o....h.s..pa..s.p.hhGhTcpElcphhp...................thpt...hppl+phYDGY....pFs..........tlYNPasll.hhp.p.....................................................................	0	142	228	252
+9653	PF09821	AAA_assoc_C	ABC_transp; AAA_36;	C-terminal AAA-associated domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4754)	Domain	This had been thought to be an ATPase domain of ABC-transporter proteins. However, only one member has any trans-membrane regions. It is associated with an upstream ATP-binding cassette family, Pfam:PF00005.	21.30	21.30	21.30	21.40	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.28	0.71	-10.04	0.71	-3.84	49	413	2009-01-15 18:05:59	2007-07-30 14:44:22	4	2	357	0	152	349	21	118.50	38	29.96	CHANGED	spLAcclpl-lD-LhPlsEuhplLshAclpsGDlpLTstG+pascuslpcRKclFsppLhphlPLsspI+phLcccsscphscpphhctLccahssptAccsLcsllsWGRYAElatY.D-	...............PcLAcpLpl-lDDLaPlsEsLphLtFAcl..c.c..G..DlhLTshGcpFs.cus.h.pERKtlFucpL..lchVPLsspI+c.lLc-.+..s..s+pssppRFtpcL..E-...a..h....o..pptAccsLcslIsWGRYuElFsYD...........................................	0	38	81	117
+9654	PF09822	ABC_transp_aux		ABC-type uncharacterized transport system	COGs, Finn RD, Sammut SJ	anon	COGs (COG3225)	Family	This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.62	0.70	-4.94	88	807	2009-09-11 15:43:23	2007-07-30 14:46:11	4	13	632	0	316	818	488	225.20	19	41.63	CHANGED	RhDlTpsphYoLSpsocplLppLcp..Plplphahss................hpphtsplcclLccYpthus.c...lplcalD..P........................ptssttpc...t.Gh.s.....................phasslll...phsscpphlshhs...................t.tthEhplopul...pclsps.....p................................................................................................................................................ptplshlsGpuEh.............................................................................................................................................sttthsphhppLppp..a..plpslsLs.................tspl..PpcsclLllssPpp.ls-pphhtlcpalh.pGGcllhhl-sh.t.............s......................t.sLss...LlppaGlplssshVhD	.....................................................................................................................................................................................................................................................................................hDhotpphaolo.to.phlp..p.lpp...............sltlhhh...hp..........t............................h.tth.pph..l..ppat....t...h...st..p....lphphhs.....s................................t....tp..............................................................................hhh.....t.t....t.p.thl.h.t.........................................Ehpls..psl....plhpt.......t.....................................................................................................................................................p.hl.hh.hpupsph...................................................................................................................................................tt..th......t......ph......tptLp......pp..a...pl.....p..p..lslt....................tppl...psss....l.lllssPpp.hsp.....pEhptlcpalt.pG...G....p....l....lhhhssh..t...........p....................................sls..ll.ppa.Glph.psshlh.........................................................	0	156	231	275
+9655	PF09823	DUF2357		Domain of unknown function (DUF2357)	Waterfield DI, Finn RD	anon	COG1700	Domain	This entry was previously the N terminal portion of DUF524 (Pfam:PF04411) before it was split into two.  This domain has no known function.  It is predicted to adopt an all beta secondary structure pattern followed by mainly alpha-helical structures [1].	20.60	20.60	20.60	20.60	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.57	0.70	-5.28	22	202	2009-01-15 18:05:59	2007-07-30 14:48:20	4	5	189	0	66	203	17	224.80	20	32.58	CHANGED	tGplsFsNclGhsphtlt.ttp....thhplphEVhssKls....app-actlLpp.....lscphsplhhphhppT.hphpts.ptstss.h.hashlcp......hhpsL.pulctIhppPHppL.pppphh+ssplpchssthhttltcpst.......................hstphhspphhptcpchohDT.ENRFlKahLpphppclt...plpptltptttphttt.....hhpplpphtcplpchLppsha+cVGphpthsspShVLpptsGY+-la+ha	..................................................hph.s.hG..ph.hh.ttt.....t.hphth-VhstKhs.....................hpp-apthlp-.....ls.p.h.tlhhphhpt.o.h.t...ht......t.t...tss....hh....thlpp........hpphhpulppIhppP+ppLhpcpphhpsccl+chsstshp....ltccsthh......................tpphh.spphhssp..+..phohDThENR....FlKahlp.p.lhcplp...........pl.hp.tl...pt...t.pp...t...........................hhppl.ppht.phpphhp.p.shhptlup.hp.t.s...S.llp.t.GYpphapha.......................................................................................	0	30	48	59
+9656	PF09824	ArsR		ArsR transcriptional regulator	COGs, Finn RD, Sammut SJ	anon	COGs (COG4860)	Family	Members of this family of archaeal proteins are conserved transcriptional regulators belonging to the ArsR family.	23.90	23.90	23.90	150.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.84	0.71	-4.91	12	29	2009-01-15 18:05:59	2007-07-30 14:48:53	4	1	28	0	26	33	9	160.40	40	94.30	CHANGED	lNDPu-LVPLhpsFsScs++KlaptLsstWhTct-l--hhGp-s..pcuLplL+KusLlEoQWRhP.csGppPpKEYHosYS+VQsNF.sShpDLuDlIhlsFhs.--lc-hh-clcphlcp.GssSlusloRsLshsPhaI+ulA+RSptLsV+GQ+lcllc-	lNDPu-LVPLLpsFsScsaK+Va-tLoppWhTcpELc-hh.Gc-s..pcuLplLKKuuLlEopWRMP.cPGppPpKEYHooYo+lpANFQCohcDLu-lIhlshhsDE-l+-hh-clcctlcs..GNsSlssLoRphslSPhaI+ulAKRSppLsVKGQ+lclsc...	0	7	21	23
+9657	PF09825	BPL_N		Biotin-protein ligase, N terminal	COGs, Finn RD, Sammut SJ	anon	COGs (COG4285)	Family	The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase catalytic domain.	24.90	24.90	24.90	25.00	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.17	0.70	-5.67	13	349	2012-10-03 00:28:14	2007-07-30 14:49:48	4	13	294	0	194	322	23	253.10	28	58.70	CHANGED	MNVLVYsGsGoTspSV+HslpoLRhLLtPaYAVssVsspsLtpEPW.spsALLVFPGGADLPYCcsLsus..ss++IpcaVpp.GGsYLGFCAGGYaGSuRsEF-lGDPshEVsGsRELuFFPGssRGsAFpGFpYsSEsGARAspLplsp........tssspFpsYYNGGuVFl-A-Ka....sNVElLAcYsEcs-lsssps...........pAAlVas+VG+GpslLTGsHPEFssp.Lpptsst......thptll-pLctp-psRhpFh+tlLpKLGLc.............lspsss.sssPsL.......Tslalsupss.......splpchhssl..p-.sspsssp....hlcsp..sDpFphtcstp....................................................s..sut.......pssphtD.ccssKpllh..pspslPspchoPpFDhctYassL	.......................................................................................................lhlYss.G.ss.......sl...c...psl.tL.+....th.ht...s...p..h...t...V.....l...ss.p...l.h..pps.W..t.p.ss.LL.VhP.......G.Gs.D.l..s.Y.s.psLs...st...................GsppIc.paVpp.GGsaL.GhCAGuYaustt.....hpFt.s.....s....thtl...upRp.LthasG...hstG..sh...h..t.s..a.Yp..op...tGs.p...s....s..l.htt.............t.h..aa.N.GGshF..ss.ph......thpllApYtp.................................sAhl.pp.......h.G.....c..GtslLoGsH.Eh..................s....t........hp....................................................h..hh..........................................................................................................................................................................................................................................................................................................................................................................................	0	71	117	161
+9658	PF09826	Beta_propel		Beta propeller domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4880)	Family	Members of this family comprise secreted bacterial proteins containing C-terminal beta-propeller domain distantly related to WD-40 repeats.	22.40	22.40	22.40	23.20	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	521	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.78	0.70	-6.16	28	199	2012-10-05 17:30:43	2007-07-30 14:50:25	4	9	169	0	97	204	204	474.40	25	72.41	CHANGED	cYSsTNlQVtGVDEuDlVKTDGphIahh.s.s..............splhllcuhP.......s.pph+llup..lshsup....pcLaL..psc....pLllls.....st.t........ss...................s..h.tshspshlYDISD.ppPclltplplsGsYlsuRhlsutlYlVssphsphh..................................h.t.p.pshhPthhss............hhhsss.hahPs.sthssa...s..slsulsl..sssp.sssssllG.su.splYsSpssLYluhsphh...h...........................................................................pt.ttpppTtla+Fslss...sclpahusGpVsGpl...LNQFShDEap.GhLRVATThsp........................................................hptpstspNslalL....D.psLchlGclpsLA........GEcIYSsRFhGDpuYlVTF+plDPLFVlDLS-PppPclLGELKIPGaSsYLHPls-s+LlGlGp-sspp.............s..p.GlKlSLFDVoDsssPpEhsphhltppsspSssht-H+AFhacpp+...sllulPls.....................h.hpshhlacls....ssGhshhuplsptsss...................lhRulYlsD.....hLYTlSpstl+shshsshc	..................................................aSpTNsQhtGVDEuDl..VK.o..DGphlahhs..t......................................pplhlhcs.s........................pphphhuplphttt.....................plal....pss.................pLllls.....pt...............................................t.sthhhaDlu.....s.t...p...Pphhtphphp.Gp.h.....hs..uRhhs.shlYllspp...h.......................................................t...t.hhP.http....................hh...tp.hhh........st.......t..sh.........h..hlsuhsl.........pssp...hs.t...sh..hG...ss..stlYhStp.slYlstpth..........................................................................................ttttTtlh+hslps....sphphhupspVsGhl.....hspFuhDEas....GhhRlsTTht.............................................................t.ttpspNslalL........D..pshphhGpl..p.slu........s.Ep.IYusRFhGcpuYhVTF+...psDPLFslDLpsPppPpllGtLK..IPGaSsYLHPh...s-s+llGlGh-stt...................h...GlKlulFDVoDsss..Ppp.htphhl......t...p...ss.S..pshhs..a+..Ahhh...st..pc............slhshPhs..............................hpshhl...apls......ppG.hphhtplph.s.............................................h.Rslals-.....hlYslotthlps.shts.........................................................................................................................................	0	56	76	86
+9659	PF09827	CRISPR_Cas2		CRISPR associated protein Cas2	COGs, Finn RD, Sammut SJ	anon	COGs (COG3512)	Family	Members of this family of bacterial proteins comprise various hypothetical proteins, as well as CRISPR (clustered regularly interspaced short palindromic repeats) associated proteins, conferring resistance to infection by certain bacteriophages.	21.10	21.10	21.20	21.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.64	0.72	-3.84	233	1845	2009-01-15 18:05:59	2007-07-30 14:51:40	4	3	1369	9	558	1538	61	82.80	23	82.31	CHANGED	M................................hhllsYDl.....ssc.......+ths+ltKhhcpaG.pplQhSVF-s.plspspht.plppclpchls...pp...Ds...lphatls...ppp..hpphthh	...........................M.......hhllsYDl.............spp............+thp+ltKhltpa.G..th..lQ..h..SVaps...pls.sspht..plhp..c.lp..ph..ls......tp....Ds...lphhpls..ppp.htp....hh...................	1	248	404	499
+9660	PF09828	Chrome_Resist		Chromate resistance exported protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4275)	Family	Members of this family of bacterial proteins, are involved in the reduction of chromate accumulation and are essential for chromate resistance.	25.00	25.00	31.90	31.90	20.60	19.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.61	0.71	-3.97	46	307	2009-01-15 18:05:59	2007-07-30 14:52:12	4	5	224	0	121	292	27	131.70	46	51.68	CHANGED	WsTRpRP+lDRlACsWLIRRFIDspAcFlaVsssp....us.hsAlsFDhcG..staoHh....G-pCoF-shlccFuL.ssPuLt+LAtlV+uADsu.phshsPEAuGL.Al.hGLSppht.DDpphLpsuhslaDALYtahc	..........WsTRpRPtlDRlACsWLIRRFIDspAcFLalsssp....ss.......tsAlsFDhcG..stao.Hh....G-tsoF-shlppFuL..psPALh+LAtlV+u.....h..Dsu...hshsP.EAuGl...Al.hGLpct.hp.DDpphLct.uhslaDuLYsah....................	0	33	66	87
+9661	PF09829	DUF2057		Uncharacterized protein conserved in bacteria (DUF2057)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3110)	Family	This domain, found in various prokaryotic proteins, has no known function.	21.80	21.80	22.60	22.30	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.04	0.71	-4.63	79	1101	2009-01-15 18:05:59	2007-07-30 14:53:04	4	3	811	0	143	559	26	179.40	33	83.49	CHANGED	ssLslsps....lclLsls...t.phpsshhpppps....lsLssG.ppQllhRapshh.......p.psssp.phhpSsshll.sFssss.pslpLphPc.hpshppAcp.Ftc.sPphpLts.ssupslshpp-hL.htsGhphspshtpplspYNt.sussAuh.......................ssssssssssssssssss.............................ttspstphLpaWappAspps+cpFhpW	......................................h.TLclsss....l-LLsls...GpK...l...u...uuL..h....cuscs....lcLcsG..aQlVFRhpchl.......hsss-c..plahSsPlll.oF.ss.p...pplshphPc.lcs...t+.-Ap+..F..st.sPplpLlD.ssupsls.lchD...hL.thsu..h..th..s.hsa-h.-...spcYNp.uuttAul..........................................sthAs.hh.ss.s.sslhssss...............................shsstupshsEppLcaWaphADspTRppFhpW......................................	0	20	49	97
+9662	PF09830	ATP_transf		ATP adenylyltransferase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4360)	Family	Members of this family of proteins catabolise Ap4N nucleotides (where N is A,C,G or U). Additionally they catalise the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulphate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP [1].	19.40	19.40	20.30	23.30	19.30	17.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.82	0.72	-4.17	64	315	2009-01-15 18:05:59	2007-07-30 14:53:45	4	8	241	0	200	306	96	64.90	31	19.94	CHANGED	sYNLlhTccahhllPRsppph...............tslulNuhGauGhlLl+sppphphlcctssh.....plLppluhs	..sYNllhTccahhllPRpppph....................tslu.lNuhGa.uGhlLV+scpphc.hlpcts.sh......plLpplGh.........................	0	47	111	171
+9663	PF09831	DUF2058		Uncharacterized protein conserved in bacteria (DUF2058)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3122)	Family	This domain, found in various prokaryotic proteins, has no known function.	25.00	25.00	25.50	25.40	21.30	22.20	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.97	0.71	-4.38	44	851	2009-01-15 18:05:59	2007-07-30 14:54:44	4	1	801	0	133	459	78	171.30	57	94.89	CHANGED	SLQ-QLLKAGLlscKKsKcscppp..+Kpp....+pp+cs......sttssp.+ttlpcs+tpptc+D+pLNcp+ptctcpKuhtAQl+QlIcts+lsp.tpG-lsYNFsD..ssKlKclaVspphpcpLspGpLAIsph......pssYtllPctlA-KIspRDsshllhhss...pspst.....-EDDPY.....A-atIPDDLMW	..............................TLQEQLLKAGLVoSKKhuKVpRTA....KKSR..........VQA.REA...........................RtAV.EEN.KKAQLERDKQLSEQQKQAsLu.KEhKAQVKQLIEMNRIsl....upGD...I.......uFNFTD..sNlIKKIhVDKLTQsQLIsGRLAIARL......E.scYAIIPAuVADKIAQRDAsS..IVLpuA.......lStEEQ.......DEDD..PY..AD..FKVPDDLMW.................	0	25	57	98
+9664	PF09832	DUF2059		Uncharacterized protein conserved in bacteria (DUF2059)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3184)	Family	This domain, found in various prokaryotic proteins, has no known function.	23.60	23.60	23.70	24.40	23.50	22.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.77	0.72	-3.95	125	777	2009-01-15 18:05:59	2007-07-30 14:55:24	4	3	654	3	230	656	55	63.20	22	31.68	CHANGED	shschppth.hshaspph..opp-lpplhsFYpSslGp+llptpstsppp.hp.thpth....spphhspl	................t..tphppth.hchYtcta.....oppElcslhsFYpSPsGpKllpppstltpc.ht.hhpth....htth....h...............................	0	52	123	178
+9666	PF09834	DUF2061		Predicted membrane protein (DUF2061)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3205)	Family	This domain, found in various prokaryotic proteins, has no known function.	21.40	21.40	21.50	21.60	21.30	19.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.46	0.72	-3.77	64	547	2009-01-15 18:05:59	2007-07-30 14:56:55	4	5	401	0	140	400	941	52.50	45	66.49	CHANGED	hhKTloatllthslshsVuYll.....TGslhluuslAhlEshsphlsYaFHERlWp+	....hhKTloFuslHFolAFsVuYlL........TG.slhlGuhlAhlEPslNTVuaYFHEKlWp...	0	40	84	119
+9667	PF09835	DUF2062		Uncharacterized protein conserved in bacteria (DUF2062)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3216)	Family	This domain, found in various prokaryotic proteins, has no known function.	21.50	21.50	21.60	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.86	0.71	-4.61	145	963	2009-01-15 18:05:59	2007-07-30 14:57:42	4	4	883	0	327	819	535	150.40	24	77.18	CHANGED	ahR....hhthhhpc.t.hhphs.+ulAtuhAlGlFsu.hhPh..shQhllAshlAhhhRu.......Nlslulhssal.oNPlThsslah.hsYpl..GshlLutss...........................................hth..hph.pWht..............htslhhPhllGullhullsuhluYhlshhlh....+hhhp+c...........h..pp+	.................h..+..ht.hh.hc.h....hhphs.+p....lAtuhAlGlFhu..hhPh....shp..hl..l.u.hh..l.A.h.l.h...+.s.......N..lshu.l.hs.s.hl..sNP.l.Ths.sl....ah....hsYpl...Gphlhstss...........................................hth..hp..hpat.th.............p.htslhhshLlGsh...lhullh...ulluYhlsthlh....chhht+php..................................	1	115	241	287
+9668	PF09836	DUF2063		Uncharacterized protein conserved in bacteria (DUF2063)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3219)	Family	This domain, found in various prokaryotic proteins, has no known function.	22.50	22.50	24.50	23.80	21.40	19.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.72	0.72	-4.00	112	668	2009-01-15 18:05:59	2007-07-30 15:01:16	4	4	545	1	222	634	74	91.00	24	35.49	CHANGED	tphQpsFtsslhssst..ss..............hs...tssspRhslYRsthhsslhssLsssFPslppllGc-tapshuptahppps..spoPhhhchGtcFssFLp	........................................thQptFtttlhtspts..........................t.sh.sscRhslY+phhhsslhssLsssaPhhp....pllGc-t...a.ptlsc.t.alppps..spoPhhpchutcFspalt................	0	55	117	179
+9669	PF09837	DUF2064		Uncharacterized protein conserved in bacteria (DUF2064)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG3222)	Family	This family has structural similarity to proteins in the nucleotide-diphospho-sugar transferases superfamily. The similarity suggests that it is an enzyme with a sugar substrate.	25.80	25.80	26.00	26.10	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.77	0.71	-4.50	93	550	2012-10-03 05:28:31	2007-07-30 15:02:34	4	8	506	1	212	557	305	121.80	26	49.00	CHANGED	Tlt........phtpssshshhlshssstspstht.....................hhssshthh.Q.suuDLGpRhtpAhpps..........ttshp.slllIGoDsPsLssphLppAhptLppp........-h..VlGPApDGGYaLlGhp....p....hs.plFpslsWSo	...................................................................hhh.......t...hthhlhhs.sthttth.......................hhhtshp..hh.Q....tu.ssLGpRhtpAhtps.........................tshp.slllIGsDsPplssphltpAh..p..tL..ppp........................-s..V.lG..PA.p.DGGYaLlGlp.......t..hs.plF.p.s.lsWup...................	0	84	161	199
+9670	PF09838	DUF2065		Uncharacterized protein conserved in bacteria (DUF2065)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3242)	Family	This domain, found in various prokaryotic proteins, has no known function.	20.80	20.80	20.90	22.60	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.42	0.72	-4.26	86	1053	2009-01-15 18:05:59	2007-07-30 15:03:48	4	1	1049	0	199	485	964	56.60	49	87.80	CHANGED	llhAluLlLllEGlh.hlhPsth+chhtpls.phssppLRhhGLsshlhGllll.allp	.....lhlALuLVLVLEGLGPhLaPpuW.++Mlsshs.pLPDshLRRhGGuLVVAGlVlhYhlR....	0	45	106	152
+9671	PF09839	DUF2066		Uncharacterized protein conserved in bacteria (DUF2066)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3249)	Family	This domain, found in various prokaryotic proteins, has no known function.	20.70	20.70	21.10	21.00	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.21	0.70	-5.24	60	369	2009-01-15 18:05:59	2007-07-30 15:04:52	4	1	364	0	106	346	429	233.00	28	62.88	CHANGED	Ahsls.sLYpucl..sVs.upsspscstAhppALppVll+loGspp..shpssslpptlpsspphlppauYp..........p.ts........phhLpssFcspplpplLppAplPlWu.ssRPtlLlWls...-sstsRp.lls...-pss..st..htptlpptAppRGlPlhhPlhDLsDphslsssDlWGtFsssltpASpRYssDsllss+lppp.s............tt................p.hphpW.pL.......asssspppt............sspuushsthspshhssluchhuscY..A	...............................................A.phssLYpucl..sVs.spps.sscstAhtpuhppVllRsoGsp.s.....sh.pssslpptLc..pssp.al.sQauap.....p.pu.................................ptsLplpFsspplcsLLpp.At...L.PhWs.psRPslLlWll...-s..s.tspp.llh.......-pss...........hhptlpptAppRG.L...PLtl.P...l.uDh.sD.ss.ls..ss..-lhGs..sss..lppASpRYssDslLll+hpts..t..................t..........................................................................................................t.h.hcW.pL.......aspssppts..........pussussppshsthhstluchhup+..................................................................................................................................................	0	33	56	82
+9672	PF09840	DUF2067		Uncharacterized protein conserved in archaea (DUF2067)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3286)	Family	This domain, found in various archaeal proteins, has no known function.	21.90	21.90	21.90	49.10	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.98	0.71	-4.79	13	57	2009-01-15 18:05:59	2007-07-30 15:05:35	4	1	57	0	44	60	7	190.70	25	92.48	CHANGED	loh+hssc-EhccFhctLp+t.htssah.lcs+h........s+lhlpl.Gs-+.clc-shppl+pLtspl+pch...pcuhhchsLpsLhR-As..hslPs-llsDALphhGhcscl+s-..hlcTsAsh-Ell-hsccLuchYpElchhslTsp.s++llsshuastshsl--slEEhlEpGlLccsEst..IsLpcshcpsc+cL	...............lsh+htsccEh.chhcpl.p+h...sh..h..lcs+h..........splhlpl.Gpcc.clc-shppl+plhppl+sch....tcGlhpYslsslhc.ht..tslshslll-sLch.hGhpschccs..hlc..Tshsh-ElhclsccLs-lhs.Elph.shsop.s+cllsssuhh..tshss--ll-chl-tGlhcctEct.+h.Lp+shcpAhc....................	0	13	19	30
+9674	PF09842	DUF2069		Predicted membrane protein (DUF2069)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3308)	Family	This domain, found in various prokaryotes, has no known function.	22.10	22.10	22.30	24.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.08	0.72	-10.46	0.72	-4.10	61	494	2009-01-15 18:05:59	2007-07-30 15:07:36	4	2	491	0	139	400	175	107.70	35	80.19	CHANGED	phluhsuh..luLlhLhhsWphhluP............................................lpsssshl......lhhlPLLlPLhGlLcGcsYTatWusallhlYFhcGlstshssss..pthlAhlEllLssshFsushhYsR.h+spph	..........................hluhhuh..lALls...LhlhWplhluP............................................lpssushl.....hlhslPLlLPL.GlL+.spsYTatWushllhlYFhculsthassss..pph..hAhlEllLshshFhushhYsR.h+tt.................	0	25	73	107
+9675	PF09843	DUF2070		Predicted membrane protein (DUF2070)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3356)	Family	This domain of unknown function is found in various bacterial hypothetical proteins, as well as in prokaryotic polyketide synthase.	21.90	21.90	21.90	27.90	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.90	0.71	-4.80	41	170	2012-10-02 15:46:01	2007-07-30 15:08:55	4	6	154	0	87	168	17	176.50	20	30.93	CHANGED	llDs+Nphssh.......lhPpspcstth.suhcphhpthth.........pphsltsGhsps....hspptslustGlpshllcsssp+sslllhDuNNhcsslhcclpctlsph...hp.h.lhToDsHhlsshstss...h.lG.hh...sscclhpthtpssppAtpslp.sp.suhtpshhp.lpshGpc..hpplsuss	....................................................................Llch+sphtsh........lhPpspcut.hpsu.hchhhcthsht.........pphplts.Ghhp..uh..sh..hscpssls.tuhtsh.llcs...s....p+sslhhhDuNNh-stlhcclp.cthspl...........h.o.DsHhl..sh.st..Gs.h.h.hGshh......scchspshptss.....pp.utpslc.sc.huhppsh...lhshGpc..hp.l.sh..............................................	0	25	56	76
+9676	PF09844	DUF2071		Uncharacterized conserved protein (COG2071)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3361)	Family	This conserved protein (similar to YgjF), found in various prokaryotes, has no known function.	21.00	21.00	23.90	23.30	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.39	0.70	-4.93	36	298	2012-10-01 19:21:02	2007-07-30 15:09:20	4	2	252	0	118	282	111	211.30	27	85.83	CHANGED	hsQpWp-LsFlHWsVDPpslpshlPsGhclDsa.-GpsaVulVsFhhpps+htulP.lPahpsF...sElNlRhYVhcpss...++GVhFhSL-ss+hhsVhsARshapLPYha..upMchppps..........tplpapupR+hs.........thp........phphpssst...scs..ssLspFLTtRathasptps.pshhhclcH.sWsLppAchhth.ssslhsusGhthss....sssplhaususcl	..............ptpWpclhFlHWsVsPptltshlP.su..hc.Dsa....-....G..p...s..a..lulVsFphpsh+htshP......l.Phhs.sF.....s.EsNlRhY.Vhpsss....++GVhFhul-ss+hh.sshluRhhht.l.P..Yhh..u.cMphppss......................pplpapop+chs.............shp...........phsh...p.h..s..s............hs..ps.....ss.lph...a...LTtR........a.th........asp.....tt.....s...phh.h.h.spH..W.Lptuchhth..psslhsstGh..ss.....s...shau.s.t...........................................................................................	0	56	91	115
+9677	PF09845	DUF2072		Zn-ribbon containing protein (DUF2072)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3364)	Family	This archaeal protein has no known function.	23.00	23.00	23.00	24.00	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.82	0.71	-4.22	10	88	2009-09-11 04:52:25	2007-07-30 15:09:51	4	2	57	0	64	91	8	101.50	22	83.37	CHANGED	PH+CT+CG+lFcDGu.cILpGCPsCGs+KFLYV+-cccsp...........cs..ctsl-phtc-tccEltpspp.c.p..t....t...................ct-RIESVRIluPGoYELNLspLhcs-ElVlul.p-EGoYhlDLsShhK+p	......................................................................................................pCtp.h..ptt...hhpGC..CG.phF.a..tt.............................................................................................................................................................................................................................h-ol.l.t.G.Y-lNl..lhpp.thlht..tppG.Y.lpl.......t..............................................................................	0	11	50	60
+9678	PF09846	DUF2073		Uncharacterized protein conserved in archaea (DUF2073)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3365)	Family	This archaeal protein has no known function.	20.40	20.40	20.60	62.70	17.90	19.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.28	0.72	-4.38	14	56	2009-01-15 18:05:59	2007-07-30 15:10:39	4	1	56	0	41	56	7	104.00	53	83.96	CHANGED	LpphsoMEKIRLILDsV+cGsIVlLEpGLoP-EEu+LIEhTMpEIsPDsFoGIEIEoYPtpp..ppuhhu+LhG+ppsp.+LTVIGPANplKTL+K-cshISAhlS	....hpphsSMEKIRhILDpV+-GsIVVLEcGLoP-EEu+LIEhTMsEIsPDpFsGIEI.....EoY...Pppp.....tssohLu+lhG+ppsp..+LTVIGPANQlcTL+KDcslISALlS..	0	8	32	38
+9679	PF09847	DUF2074		Predicted permease (DUF2074)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3368)	Family	This domain, found in various archaeal hypothetical proteins, has no known function.	29.60	29.60	29.60	30.50	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.78	0.70	-5.73	10	50	2009-01-15 18:05:59	2007-07-30 15:12:31	4	1	46	0	31	52	3	416.40	21	86.14	CHANGED	slplshhhpSluFhhhulhlsssuhhuc+ts....hhSshlll.FlaslasTuhssuahhou....+ll-PL+uLPlshhsplhuVhhhI-ohsuhhFll....hlushhlsshstuLLGLlWuhhulLhG.aSluhllhltFGsphsGRtohs+slh+shGhllhhh.lhulahll.h.hphl...sthlsslhphYphlaP........hhs.sIhtshhu..hlLullYh.lhhshhYhhsl++LappL...EstcspGplphchpl+scushlohlhKDaKllhR+oQsLshlLhPlahslhhlhslsp.s..hh.....hshhhlshlsllSSlhLphhhtIEssGF......phLpSLPls++chlhsKhLhhhlI.hhlshslhhlshlass.tsslYhhhllssslLsshluhhashp+l......su-slphssh.GhlssIlhhllshlslulsulhsFhLstPlu......allssuhsl....IsuLllac+	..........................................................hh.p.h.ahhhshh..h.....hh..p.........h...hh.....l.hlhsl.ahoshtshhhhst....tlhp.LhsLPlp.t.....s..hhl..u..hh..h..hl.ph.hh.hhlh....hhss...h...hhhhh.ul..Lshlhhh.htlhhh..a....slu...hhlhhhhGtth......+huhspslh+..h..hshll.hhh.l..hh...hahh....................thh....l..hh.hhaP........hsh.sl.t......hll...llYh..hhhshhahhsh+tl.h.pl.........hpuchp.hphp.h.phpsshhuhhtKDlKhlhRp....sph....lh.hllhPl.hhslh.....hhshl.....................hslhhlh.hh.shho.uhhhth....hhtlEtps..h......plLpoLPlsh+phhhuKlLlhs..ll.hhl.hh.hhIhshlash....sthhl.hhh..hlhsh.ll.sstluhhh.shpp.h.........pscslphs.h....shhshl.l.hhllts...l....hlGlsul.h.hahhshhhs................hlhshh.hl....l..h.......................................................	0	13	16	25
+9680	PF09848	DUF2075		Uncharacterized conserved protein (DUF2075)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3410)	Family	This domain, found in various prokaryotic proteins (including putative ATP/GTP binding proteins), has no known function.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.18	0.70	-5.48	63	776	2012-10-05 12:31:09	2007-07-30 15:18:44	4	21	611	0	219	3403	1226	288.50	20	51.73	CHANGED	+plhllpGssGoGKollulslhscl..............sp.............ppthstalssNps.ht.....hlpcplstsh..........tthhpphhtpssuFIpshp......................t.sphDllllDEAHRLhs...........pts.......h.phtt.tsplp-lhcp.u+..lslhlhDpsQtlphs-hsshpp.....lcchhpphshpht.................................pLssQhRs.tuucshlsWlcsllphpthtshsh.............ppsa-h+lhcsspphppt.......lcp+.....sptss..p..uRllAuasasht.....p.psshtshhl.......tp.aph........................tWshpst.....................Wspps.psl-cVGola.....TsQGhEL-YsGVIlGs-lhac......psththptp..phpDtsstpp+.................tt.htpllpNsY+VLLTRGhcGhalassD	.................................................................................hhhlpGssGoGKoll.h...h..plhtcl..............................................t..................................................................t..tt.p.s.......a.l...s.....h...N.....p..s.....h.....................h...l..h...p..p..lspph..............................h.p.p....h..h..p....s......s.....s.....h..l.pphp...................................................................................................tph.c.ll.llDEA.....p.hlhs...................................................p.t....................t.h.t....tspl.p.clh......pt....sc..............lhlh.hh.D.t...t.Q...h...l....p....pphht.t...............lpp..hhtth......h.t........................................................................................................pLppphRh.....t.......s.....t...t...h..h..p.....a...l.pt.hht...t.................................................tta...phphh...ps...tt.......h.t................l.tt............................................tt...................thh.s....s.sh...............................h........................................................................................................W.....................................ht.....phus.a.....shQGh-hsashlhhs.sh.........................t...p...................................hhhp.h.hLhpRuh.Ghhlh.........................................................................................................................................................................................................................................	1	59	123	170
+9681	PF09849	DUF2076		Uncharacterized protein conserved in bacteria (DUF2076)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3416)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. The domain, however, is found in various periplasmic ligand-binding sensor proteins.	38.00	38.00	38.40	38.40	37.90	37.60	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.75	0.70	-4.32	44	304	2009-01-15 18:05:59	2007-07-30 15:19:05	4	3	286	0	119	304	5	229.80	31	98.75	CHANGED	MsspEppLI-sLFsRLppscss.........PRDspA-uhIsctlppQPsAsYhhsQslLVQEtAL+phpt+lppLcsph..............stttttt.uGGFLu.uh....FGustsp...s.Pts..ssts......................tssasptts..ts..............p.thsts............t................GuFLGsAhsTAAGVAGGslLhsulpshFssspt.tthss..t..................ssss.u..........p-sshsshtsspsts............................h-pus.st.s..shsDus.sss.s.s...................DD........Dssa	..............................................................................MsspEppLI-sLFsRLppApst.......................sRDspAEthItptlppQPsAsYhhsQslLlQEtALcphppclppLctpltt..................tptttttuuGGFLu..ul...........FGuuss.p......stPss.tssts......................sshsttt......s.......................psshsts...............ts.................uGFLGuAhpTAAGVAGGh....lLusulsuhFstppt.tthsthhtt........................t..tss..............ps..ss.hss.hh.sssss........................................cpst..s..........ts..tDss.sss.s..................s......................................................	0	25	56	86
+9682	PF09850	DUF2077		Uncharacterized protein conserved in bacteria (DUF2077)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3455)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.90	20.90	21.30	21.70	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.17	0.70	-4.92	122	1603	2009-01-15 18:05:59	2007-07-30 15:21:13	4	8	979	5	300	1102	33	200.90	26	64.69	CHANGED	NsLlss.ussLlthlspl+p..tsptssh.tplcpplhp..plpphcpph.pptuh......stpplhsu+YsLC.shlDEslh.sos....Wutpu.....tWtppsLhspaas-s.GGE+hFphLpclh..ppPtpphclLElhYhCLsLGFcG+Y.ph.tpGpp..plcplpppLhphlpph..........t...t....sl.ssphpssststpph.ptt.hPhW.hhhulss.hlhhshahshphhL	.............................................psllss.spsLlthlhplpp......htstsps..ppl...tpplhp..plpthcpth..pptuh...........p.tppl.hsh+Ys...LC.shlDEu...sh.sss....Wusps.............................tWtppsLhspFas-s.GGE+hFplLc+Lh...ppPp..p...hhslLEhhahsLsLGF.cG+Y..pl.........tp.upt.........ph-pl...hp....pLhphlpph......tsh.....................sl..ssphttst..ss..php..h....t.........p..t...lshh..hhhshsh..llhh..hhahhhphh..............................................................................	0	50	115	206
+9683	PF09851	SHOCT	DUF2078;	Short C-terminal domain	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	Jackhmmer:B0PET9	Family	\N	24.00	15.30	24.00	15.30	23.90	15.20	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.20	0.72	-4.34	733	1938	2009-09-13 15:00:14	2007-07-30 15:22:51	4	75	1219	0	751	1854	980	30.70	31	15.57	CHANGED	htspLcpLccLhspGhIoc-EFcppKpcLLs	...........ppLcpLccLhspGhIoc-EappcKpplL...........	0	286	560	699
+9684	PF09852	DUF2079		Predicted membrane protein (DUF2079)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3463)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	22.00	22.00	22.10	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.56	0.70	-5.77	53	276	2012-10-03 03:08:05	2007-07-30 15:24:01	4	2	206	0	118	317	177	416.90	18	80.11	CHANGED	Rahsh.......ssuaDhGlFsQhlaphupG+.h.hSohps..................ptLGpHhs.llhlhs.....P.lYtla.Ps.hsLhllQshhluhuulslatLAppt.t.s........pphuhhlshlahht.sslh.ss.sL.asFHs.shhh.Phhhhulh.uhpp........c+hhhhhlhhlllLhs+-shulslhulGlhlhlp.................c..............h................uhshhhhuhsahllsspll........hPha.sst.t....hhhtt.....................au.hh.......sushpllhshltpPh.hhhptlht.......slhY.llhlhlPhhalshh..........s.shLlsulPllhh.llu.stss.hslsa..+Ysh.llPhlhlusl..shpptp......................................phthhWssshhLuLshshhhs..................................hsYhshhpphsps...ppslshlP.ssuuVhss...........s.LhPpLup..Rpslhhhsts....hp..........t...pph-allls.........t..shtsstct.pphlsphpppspaphhht...psGlhl	..........................................................h........suaDhGlFpQhhh.hs.p.tp...hsshpt..................phhusHhs..lhhlls......s.lYhla....Ps...s.h...hLl..llQshhl..uhuulslahlupph..h.s...............................pthuhhh..uhsYhL..sslh...ss..sh.hs.....FH...shuh..Ph.lhhuhh..shtp.............pphhhhh...hhs..hhllhs+-.....s.h...ulh..lhs.h...Gl..hlhht......................................................................................p.......................p..th................................uhhhhhhuhsahhlshtll........hPhhtts...............................as.hh....................................suhht.hhhshltpPh..hhlttlhs.s........................plta.llhlhhshhhlshh............pshhllsslPh.lhhphlu.s.s.....hshhh...pY.shslhPh.lhhusl...shtphp.................................................................................................t.h.hh..hh...shh.....h.h.h..shh.hhhhhs.................................hhhp...hppht.th...pphls..lP..ssusV...hss...............s.lhstLst....+p.lh.hh.tt......................t.callls.................................h................h.......................................................................................................................................	1	38	74	102
+9685	PF09853	DUF2080		Putative transposon-encoded protein (DUF2080)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3466)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	21.00	21.00	21.00	21.00	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.36	0.72	-4.23	6	51	2009-01-15 18:05:59	2007-07-30 15:25:35	4	1	29	0	24	55	12	47.10	31	78.22	CHANGED	lpIpKcoW+Ks+phhsoFhshVpshGNSAplD..lPKEYlGKTVhlTll-cD-	....................t.h..pth.s.ha.tpVp.hGNSA+ls..lP+-alGKplhlsllcpp........	0	10	15	20
+9687	PF09855	DUF2082		Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3478)	Family	This domain, found in various hypothetical prokaryotic proteins, as well as some Zn-ribbon nucleic-acid-binding proteins has no known function.	20.60	20.60	20.60	20.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.21	0.72	-4.13	18	259	2009-01-15 18:05:59	2007-07-30 15:27:38	4	2	254	0	56	152	85	63.10	45	87.63	CHANGED	atCPKCGsssa-psplpsTGGshSKlFDVQNc+FhsloCppCuYTEFY+....upsSshtNlhDhhhu	..........sC.KCGs.....p.....pYtscphp..u.TG.Gshu......K....l..FDVQN+.+.Fl.....ol......o.......CspCGYT.ElY+......upoSsuhNlLDhhhG............	0	22	40	48
+9688	PF09856	DUF2083		Predicted transcriptional regulator (DUF2083)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3800)	Family	This domain is found in various prokaryotic transcriptional regulatory proteins belonging to the XRE family. Its exact function is, as yet, unknown.	21.30	21.30	21.40	21.30	20.70	21.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.06	0.71	-4.57	67	753	2009-01-15 18:05:59	2007-07-30 15:28:12	4	8	475	0	213	613	820	153.00	46	32.83	CHANGED	TLQRPGA+GlPFFFlRVDpAGNloKRh.SAosFpFuRaGGuCPlWsVHpAFtp.PGcllsQluchPDG....ppYlslARoVspssuuastss+phAluLGC-lpaAsclVYAcGl...........sLssssu...sPIGhuCRlC-RssCsQRAhPPls+tLtlDppppuhsPY	...................................TLQRPut+GlP.FhFlRlD+AGNloKRp.SA.suFpFuRhGG.sCPLW....sVapAFs......p.PG+..ll..p.Q.lAph.P..D.G....pp..Yl.hlARTlpp.ssuu.as.tPs.+paAluLGC-lpHApclVYusGl...........................cls..ssss...sPIGsuCRlC-RpsCsQRAhPsls+tLslDpptpsh.PY..........................	0	47	134	177
+9689	PF09857	DUF2084		Uncharacterized protein conserved in bacteria (DUF2084)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3811)	Family	This domain, found in various hypothetical prokaryotic proteins,as well as proteins belonging to the UPF0386 family, has no known function.	21.50	21.50	22.30	50.10	20.80	21.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.70	0.72	-4.28	25	284	2009-01-15 18:05:59	2007-07-30 15:29:07	4	1	276	0	48	145	6	84.50	70	98.69	CHANGED	MNISKsEQRlLHlLAQGGcIphpRs-sG+lsclpChTR-GahLusCoLsVFc+LK+KRLIpScsGpPYRITcpGLpsVRuQLDNR	.....MNLSRQEQRTLHVLAKGGRIsHlRDuSGRVTuVECYSREGLLLuDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNsVRAQsDNR............	0	15	25	35
+9690	PF09858	DUF2085		Predicted membrane protein (DUF2085)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3815)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	26.10	26.00	24.00	21.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.35	0.72	-3.91	24	150	2009-01-15 18:05:59	2007-07-30 15:29:42	4	2	123	0	61	129	105	88.10	34	60.70	CHANGED	hCHQhs-RSaahtGpQhPlCARCTGIYlGhll....shlhh.......hthhshslhlhllhhlP.hslDGhsQhhs...............hhcSsNh.......LRhlTGlhhGhuhshhl	...............CpphspRohhhhsh.hslCARCsGhhlGhlh........hhlhhhh.........hhh.h.h.h.slhl.sh....h.h..h.lP.hhlDGhsQhht..................................htpSsNh.......LRllTGlLsGhuhuhh................	0	26	46	56
+9691	PF09859	Oxygenase-NA	DUF2086;	Oxygenase, catalysing oxidative methylation of damaged DNA	COGs, Finn RD, Sammut SJ	anon	COGs (COG3826)	Domain	This family of bacterial sequences is predicted to catalyse oxidative de-methylation of damaged bases in DNA.	25.00	25.00	25.40	25.20	24.30	21.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.06	0.71	-4.94	42	288	2012-10-10 13:59:34	2007-07-30 15:30:15	4	1	258	0	107	277	10	168.60	57	71.64	CHANGED	RGEY+YFsYPLPchltpLRsuLYP+LsPlANRWspphGhssRaPsphs-aLspCHtAGQpRPTPLLLpYusGDYNCLHQDLYGEhVFPLQVslLLScPGpDFoGGEFVLTEQRPRhQSRupVlsLpQGDullFsspcRPVpGsR.GhYRVshRHGVSclRSGpRaTLGlIFHDA	...................pGEY+YFsaPLP..phlppLRpuLYP+LsPlANcWttthGh.-spaPsshscaLtpCHsAGQsR....P....TPLlL+YGsGDaNCLHQDLYGEhVFPL.QVsllLScPGpDFTGGEFVLTEQRPRhQSRup..VlsLpQG-..ullFss+cR..PVpGsR.G.hYRs.....slRHGVSplRSGpRa.TlGlIFHDA......	0	31	58	87
+9692	PF09860	DUF2087		Uncharacterized protein conserved in bacteria (DUF2087)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG3860)	Family	This domain, found in various hypothetical prokaryotic proteins and transcriptional activators, has no known function. Structural modelling suggests this domain may bind nucleic acids [1].	22.40	22.40	22.70	31.70	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.34	0.72	-4.22	55	586	2009-01-15 18:05:59	2007-07-30 15:32:31	4	10	465	0	149	460	21	72.10	36	40.26	CHANGED	G+LpphP.u..+pp++lllLphlhppF.c.sppYoEpElNpllpph..a.s.DaAhlRRtLl-hGhlpRp.tGutY.......Wpt	.........................G+LpphPp....+pK+Kll....lLpclh.p.c.h.css..ppYoE+EVNp.hlcph..........as..DasslRRhLl-aGalcRst.GstY.......hh.............	0	64	116	134
+9693	PF09861	DUF2088		Domain of unknown function (DUF2088)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3875)	Domain	This domain, found in various hypothetical prokaryotic proteins, has no known function.	23.30	23.30	23.30	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.92	0.71	-5.30	50	648	2012-10-02 00:55:42	2007-07-30 15:32:58	4	4	416	2	239	630	126	196.70	26	45.88	CHANGED	YGcs..plplplP-cplhullpspt..htshtctpphlpcALpsPIuopsLp-llpst..c+lsIlsSDhTRP.sPs.......chhlPhLlccLpt.Gl.-csIpllsAhGhHRtpTcEEhtphlG......p-lhpch....cllsHsspDcsshshlGpos..............pGsslhlN+hssEADhlIssGsIp.HaaAGaoGGpKulLPGlAuhcTIhsNHsh...hl.ssputhG	....................................................................pt.....h.l..t........thh......t..............s..tthlpp...ulp.p.Plss..................Lpchsps....t..........cplsIlssDh....TR....s..sss.......phll.shllccl.pp....sh.ptp.l.tlls.AhGsHRst.Tc-.Ehtphl.G......pc.lhp.p.h....pll.sHpspsppshlpl...G.p.ss........................pG.sslhlN+hsh..E..u..D..hlIshGhlpsH..h.a...u...G...a...SGG.tKslhPGluuhcolttsHsh.hl.t........................................................	0	137	205	230
+9694	PF09862	DUF2089		Protein of unknown function (DUF2089)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3877)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. This domain is a zinc-ribbon.	29.10	29.10	29.20	29.80	28.30	29.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.26	0.71	-4.28	18	297	2012-10-04 14:01:12	2007-07-30 15:33:38	4	2	274	0	103	262	1	98.50	33	87.76	CHANGED	CPVCGcchpVT+LcCspCsTsIEGcFclscFspLopEphpFlclFlKsRGNIKElE+ELGISYPTVRs+L-cllsALGa............psps-tpsc+c-lLccLccGEISsEEAlchLK	..............................pt.t.h.l.ph.h.t..s.h.lpspFt....s.................h..hspLspEchpFlchFlpspGslKElp+phulSYPTVRsRLDclIpplsh....................tpt.t.t....plhp.l..ptpls.ptA......................................	0	52	76	92
+9695	PF09863	DUF2090		Uncharacterized protein conserved in bacteria (DUF2090)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3892)	Family	This domain, found in various prokaryotic carbohydrate kinases, has no known function.	21.40	21.40	21.40	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.98	0.70	-5.58	34	447	2012-10-03 05:58:16	2007-07-30 15:35:24	4	3	431	0	108	433	338	300.60	50	48.52	CHANGED	ELsaaLpcup..phs....c.cpDtpLp+LHtsTsR+.......ppWspLplhAFDHRtQLt-hAtpsGushs+IsshKpLhlcAutpVsp.....Gh...thGlLsD.spa..Gp-ALppAoGpGa.WIGRPlElPGSRPLchE..tGtslGupLhcWPtEHVVKCLsFYHPDDsstLRtcQEpplpcLapAs+psG+ELLLElIs.....Pcs.....tPhs.DsshhcslcRhYsLGlhPDWWKLtPh.ospuWpplsslIpc+DPaCRGlVlLGL-APt-pLtsuFtsAAs.slVKGFAVGRTIFu-su+tWLsG-lsDtphlscltspatpLlshWcptR	.................................................................................................ELs.aLtRup..phs....RPDtDspLsHLHRVTs.R+.......ppWscLplFAFDHRpQLh-....h.A....p..p....s..G..A....s.....s....+I....stLKpLhLc.Auppsutph..................Gl...pspsGlLsD.spa..GQ-A.L.N.ss...T.G.pG......W.....WI.....G..R.P.lE...hPG...SR..P..Lc..hE..+G.slGS.pLlsWPt.......E.......H.......V.......V.......KCLVFYHP-DssplRhEQEtplpclacAsppSGHELLLElI..............Pcs...............t.s.sp...-phhhcslcRFYpLGIhPDWWKLsPl....osssW.......pplsplIpcpDPaC.RGl..VlLGLDAPtpcLcsuFsuAAshshVKGFAVGRTIFu-sSRpWLuGclsDtpLIupltppYppLIshW+pt...........................................................................................................................................	0	15	46	76
+9696	PF09864	MliC	DUF2091;	Membrane-bound lysozyme-inhibitor of c-type lysozyme	COGs, Finn RD, Sammut SJ	anon	COGs (COG3895)	Family	Lysozymes are ancient and important components of the innate immune system of animals that hydrolyse peptidoglycan, the major bacterial cell wall polymer. Various mechanisms have evolved by which bacteria can evade this bactericidal enzyme, one being the production of lysozyme inhibitors. MliC (membrane bound lysozyme inhibitor of c-type lysozyme) of E. coli and Pseudomonas aeruginosa, possess lysozyme inhibitory activity and confer increased lysozyme tolerance upon expression in E. coli [1]. Structural analyses show that the invariant loop of MliC plays a crucial role in the inhibition of the lysozyme by its insertion into the active site cleft of the lysozyme, where the loop forms hydrogen and ionic bonds with the catalytic residues [2].	21.30	21.30	21.30	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.68	0.72	-4.24	101	1381	2009-01-15 18:05:59	2007-07-30 15:40:44	4	15	1175	9	224	727	37	71.70	32	55.43	CHANGED	YpCt.....ss...pplpspahsssp.........shlphss....pphhhspsh.SASGA+Y.......sss.phpa.W.sK....G.s-Ahlthttpss.........sC	.............................YpC.........sp..pslsV.phsNsppt............ssh.s.hcs.......phl.hLppsl.S.AS.GA.RY........scu...hYsaW..oK....G...cpAplhppcchsh..........................................	0	47	108	166
+9697	PF09865	DUF2092		Predicted periplasmic protein (DUF2092)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3900)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	27.50	27.50	27.50	39.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.26	0.70	-5.28	17	95	2009-01-15 18:05:59	2007-07-30 15:40:57	4	4	74	0	50	114	16	209.90	29	77.32	CHANGED	cAhplL+sMusaLtutpphShph-ssh-slhtsGQKlpauuouplslsRPD+lRssh.pushscschhaDGKTholhu.ssshYupsstsu.slD...tll-cLpschulplPhuDLhlss.shstlt.pslhsuhhlGps.slsGs.CcHLAFRps-lDWQIWIspGspPlP++hVITt+pssupPQaolphpsWshss.shssssFsFpPPssAcpl-h..ssh	.....................................A.plLcpMusaLtstcshohshcssh-.lhtsG...pKlpasu...ssplplpRPs+LRssh.pGs..tsst.....c..hhaDG+s.hTlhs.stshYuphssPs.ol-...ph.l-plppchulphPh.uDL...l..hss.shsslh.sslpsuhhlGps.hlsGstCcHlAFp....pps.hD..aQlWIspGspPLPp+hlI.T.+sh....sup....P.......Qassphp...sWshss.phs.sssFsFpPPssApplchh.h....	0	14	29	41
+9698	PF09866	DUF2093		Uncharacterized protein conserved in bacteria (DUF2093)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3908)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	26.80	63.90	24.40	18.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.13	0.72	-4.78	30	196	2009-09-10 21:13:40	2007-07-30 15:41:37	4	1	191	0	75	146	668	42.10	57	55.22	CHANGED	llpsGsaVhCAVTGppIPLD-LRYWSVc+QEAYss...uptuhpR	..llpsGoaVpCAVTGtsIPLDEL+YWSVsRQEsYAo...sthuhcR......	0	19	44	55
+9699	PF09867	DUF2094		Uncharacterized protein conserved in bacteria (DUF2094)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3913)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.80	20.80	23.80	27.20	18.40	20.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.72	0.71	-4.28	33	490	2009-01-15 18:05:59	2007-07-30 15:43:05	4	6	421	2	119	397	5	130.00	25	47.21	CHANGED	GaaGKlPutGDFVp+pLPpuhlpsWDsWlppulssspp..thsttWtpsahsuPlWRFslssulsG....tshsGllhPShDRVGRtFPLslssslssss.....s.hhhstssaaptlcshhluslctsssh..-tLspuLssLssP	..........................uaaGKlPutGDF.l.ppths.thht.hctWhttu.hth.tp.....t...t.ht.tsappsssWpFshssuhhs....tthlsGslhsSpDpVGRhaPlllhpthshpp.h......spthttstt.ah.ttltphhhptlp.spt.h..tthtptltth...h..................................................	1	19	49	81
+9700	PF09868	DUF2095		Uncharacterized protein conserved in archaea (DUF2095)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4003)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	39.40	31.50	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.80	0.71	-4.36	3	25	2009-01-15 18:05:59	2007-07-30 15:43:31	4	1	25	0	21	28	1	109.50	47	90.30	CHANGED	EKKKKPIDELPWQEYDIEEFKc+FPALARELEE-hG.LEIoGIRLDEYQVLEEEEEE.KIDFSGYNPTIIDFLRRCDTDEEALEIINWMEE+GEITPEMAKELRVTLVHKGVRAFGPKKEWGWYERHGKH	..................pY-h-EF+c+aPtLA+El..-tpu.l.Ips.phs.......-.......sauGYsPTVIDaLRRCcT-EEALEIINahEc+GEIopEhAc-LRhpLs+KGVRuFGs+KEhGaY.ER+u..h......................	0	4	9	14
+9701	PF09869	DUF2096		Uncharacterized protein conserved in archaea (DUF2096)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4010)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	22.50	22.50	22.50	140.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.87	0.71	-4.38	7	27	2009-01-15 18:05:59	2007-07-30 15:43:47	4	1	27	0	19	25	2	169.20	39	95.52	CHANGED	l-pQWVVLsELsocL.p+uh.VPp-VhpcLRhApsllsaYhhD.Hs..shc.Ltcs-+.LsplQthLhsls-...sDhsccal-Kht+AhRsEhshc.PhppSpFp..lp+....tss-sIRVph.c.lp.EhLt-luEapGVIhEh..--sDh.VhI.Gs+-clppALK-hu.h...W+p	.lDppWlVLsELsocL.p+shtlPcplhpcLRlApslIoaYhlDsHs..shcsLpcsE+pLsplQthLhsLs-...t-hsccaLpKht+AhRuEhshcFPhp+SpFp..Vp+....ssh-slRlplpptlp.ERLt-luEapGVIhEa..E-csp.llIcGsc-+lppALK-hush...WK...	1	4	9	15
+9702	PF09870	DUF2097		Uncharacterized protein conserved in archaea (DUF2097)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4013)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	36.90	60.60	23.90	20.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.79	0.72	-3.90	8	32	2009-01-15 18:05:59	2007-07-30 15:44:29	4	1	26	0	22	31	4	88.80	31	93.27	CHANGED	hclIch.......osEEhlEYl+cNVc.sDhlElsauRlalsGcVlshss........shlpLpl-uchh.Glh-lDlccIp-DlLElhHhsc-G-phlll	........c.lph.......ss--hlEYlcssVc.sDhlEl.asRlal.Gcllshps.........shhplph-schh.sh.lElDlccIp-DLlElhHhsc-scctll.h....	0	5	12	18
+9703	PF09871	DUF2098		Uncharacterized protein conserved in archaea (DUF2098)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4014)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	56.50	56.30	22.70	21.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.10	0.72	-4.05	16	48	2009-01-15 18:05:59	2007-07-30 15:45:13	4	1	48	0	38	46	2	90.10	31	91.83	CHANGED	c.IclGshVRYlsTGThGpVpcI.KsEsscpWllL...-sosLaYcschLEls-...tp++pc+..chst-Ehl-+l+ccc.-thpphDlssssss.....GGG	....IplGshVRYlsTGThGcVscI.Ks-...ss.cpWllL...-sosLaY+schLElh-...tp+cccc.......ctstcEhl-+lcppc..c.....thpthchstttss...GuG...................	0	8	24	32
+9704	PF09872	DUF2099		Uncharacterized protein conserved in archaea (DUF2099)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4022)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	226.80	226.60	18.00	17.60	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-5.36	22	64	2009-01-15 18:05:59	2007-07-30 15:45:37	4	1	51	0	50	63	6	256.00	45	90.71	CHANGED	HlhEslG+s..RVll+sG..KVlEVu-PtlcaCPLacKhR.GlcclTpEsl+cNlEaRIc-FGMhTscRplchc.sFVuFGsSElhhTuLppGhlDAsVhVCDGAGTVlsssPpLVQGlGGRhSGLlcToPIsEVIc+IccpGGhVL-.psApID.ltGlctAhchGY++lAVTlusspsAcp..lRcht..................pssclhlhuVHsTGl.op--AccllphsDllTuCASKhIRchst.+slhQlGsulPlFAlTptGKcLlhcRh+-	....HlhEsLG+.u..RVlV+sG..KVl-VuEPhlcaCPLFcKaR.GIc.clocEsI+cNlEFRIc-FGMhTscRplchc.sFVuFGsSElhhouLpcGhlDusVhVCDGAGTVIsssPpLVQGlGGRlSGLlcToPI.-..VIc+Ic..cpsGhVLD.psAcIDQltGVc+AlchGYK+IAVTVs..s..s..c..c..AcclRclEt.................tslclhlFuVHsTGl.sc--AcplhchsDllTuCASKhlR-hst......t+slhQlGsulPlFAlTppGK-LllERh+.....	0	13	35	43
+9705	PF09873	DUF2100		Uncharacterized protein conserved in archaea (DUF2100)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4024)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	22.20	22.20	22.20	141.00	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.44	0.70	-4.87	6	22	2009-09-11 01:16:15	2007-07-30 15:46:46	4	1	22	0	16	22	0	216.40	46	98.18	CHANGED	cschSK-LI+KAlpTIS+pc+sh.h.p...p..pch.apDAcsG+IDssEhK+AlapLIEAD-YLYKoAPsH-LspEcAcEFsKlLhpspcHIs+ILupFGF.Eh.EsphclD-...suLYIVuNKKlhKsL.KplsssLNIlsTEGsL-lEDM+hlNPcIPEKALhGIEKKscIs+cpIp+hIpKlsPp+lVVVVccsDsuDELlapR....AKEL.YsAE........KLsu--IL	............chp.SKcLI+KulpTISchcp.....hh.p................pppKch..apDAKsG+IDssEFKKAlapLIEAD-aLYKpAPpH-Ls-EcA+EFsKLlhpsp+HlsplLusFGF.Eh....E.p.tclDc...sALYIVSNKKlhKpL.Ksh.ss............sLsIlsTEGsL-lEDMKhINPpIPEKALtGIcKKscIsKcpIp+hIpphpPsKllVVVc..DcuDELlapR....AKEL.YNAE........Klss-ElL.............	0	3	6	12
+9706	PF09874	DUF2101		Predicted membrane protein (DUF2101)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4025)	Family	This domain, found in various archaeal and bacterial proteins, has no known function.	20.40	20.40	20.50	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.36	0.70	-4.84	5	26	2009-12-03 16:38:53	2007-07-30 15:47:35	4	1	26	0	17	25	0	175.90	32	81.10	CHANGED	hKsaLlPpPS-chP+S..hlh+lsKRshTPHELlSL+LQLlFLlYLI.lSLlssa.LpshLlLIlsuslhFLYLRYlLIRNp-ahl..DFcAYRsF...YlulSTIsFlualGYlLlRcaopshaaYLsYLusIslsVllFRaYFKsRYGRDYTYGlVEEVKsDLV+VFVHDDIAANVKPGYYWVPAVu.-A-sGDIVKLLVEpRT..FRGS+PVRIL	......................................................h.ph..p.+EhhsLhLQlhhhhall.hsl.l.h...hh.h.....hhh.ht.hhYhlh..LpalLhpshshhl..ca.EsYphF....YhululluhLshhGhlllc+huhc.sh.Yhshlshlhl.sVlhhhhhF+.+ahRsaTYGhV..Eltts.hshVhVp.DltuNVKPshYhV.tss.sh..GthVKlhVEpph..h+ushPh+Il..............	1	3	5	11
+9707	PF09875	DUF2102		Uncharacterized protein conserved in archaea (DUF2102)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4029)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	38.80	38.60	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.34	0.72	-4.51	16	54	2009-09-11 09:37:18	2007-07-30 15:47:51	4	1	50	0	42	51	3	102.20	45	70.17	CHANGED	hlllusss.soPu-lshtlaplshs.lpIKETCFGshIsGcc-sVccllcclRshDss+IFsK-RGFPsGDsRRCRApRGGu.RPGFHtLEtEhplLshIucAL-	..............hlllussu..soPuclsthlapl........shs.lplKETCFGshIpGcc-hVccllcclRpl-.s+IFsKDRGFP.GDtRRCRApRGGusR.GFHtLEtE.clLshIucAL-............	2	9	27	36
+9708	PF09876	DUF2103		Predicted metal-binding protein (DUF2103)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4031)	Family	This domain, found in various putative metal binding prokaryotic proteins, has no known function.	20.80	20.80	21.00	21.00	18.90	20.70	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.29	0.72	-4.27	11	139	2009-01-15 18:05:59	2007-07-30 15:48:36	4	3	138	0	78	142	101	95.60	31	69.35	CHANGED	s-tssccKlGGoHSTlIGGRpGpKhlpplApHPcVKKVIPGsIsusGsu..uG.lcuKVT.RuDspGNlRLLlp-GoSVQElRlVTTAuDcEpG-clhc-LN-hL	.................h.....pt+lshsHSThlsGh..h.hLcplupp..stlcslhPGsIs.tspup..pss....lpl+lo.hsspsG.hKLlARpGsoVQElFlVTshspc-..pt.........................	0	20	51	70
+9709	PF09877	DUF2104		Predicted membrane protein (DUF2104)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4035)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	22.80	22.80	24.90	24.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.31	0.72	-4.04	8	27	2009-01-15 18:05:59	2007-07-30 15:49:00	4	1	27	0	17	25	0	96.20	44	94.03	CHANGED	hl.FhlLlsslsFIlGShlGLpYSY+KYscPalE+plDslALllAVlGhl.lhVNss......hhhhlGhhhluaslGMRPGYGRhEhllGlllAlIlalLpt	........h.hLlshlsFlIGShlGLtYSY+KYspPal-KplDhlALllAllGul.hhlNss...........h.luhhhluFslGMRPGYGRhEhhlGlllAlllallh.h..	0	4	7	13
+9710	PF09878	DUF2105		Predicted membrane protein (DUF2105)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4036)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	25.00	196.40	22.50	24.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.50	0.70	-4.76	10	32	2009-01-15 18:05:59	2007-07-30 15:49:21	4	1	32	0	21	29	0	216.30	50	96.77	CHANGED	M-hshplapsslhsGlIlGhluLlsIuh....pKsDLshlllTDLlEhuMLVlIAuVGTDLAEALILPGLVVGlAELLAVSElhluR..........................p.+lhEchsl.phss..........h+hEVLcTAPsFlAllLVVYGllLoGFTGGAVAusGLLFYhLo++spsh.h......hpaEGIuulSGIuWALWIhGFlhFFlaPptWLhuLhlAGsG.lllKVuSKlGLIGslhc	.......phh..lapsslhlGhllGhluLhuIuh....pKsDLphLlLTDLlEhAMLllIAuVGTDLAEALILPGLVVulAELLAlSEIhloR..........................c.+lhEchhh.phss...........hchEVLpTAPpFlAl..lLllYGslLSGFTGGAVhuuGLLFYslS++shGh.h......hpWEGluulSGIAWAlWl.hGFlsFFlhPphWLhsLhlAGhG.LllKVuSKlGLIGhlh.c.	0	5	11	17
+9711	PF09879	DUF2106		Predicted membrane protein (DUF2106)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4037)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	193.50	193.30	22.70	17.10	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.85	0.71	-4.88	9	32	2009-01-15 18:05:59	2007-07-30 15:49:49	4	1	32	0	21	29	0	151.80	54	93.62	CHANGED	tpls+lhNhlSpPcsls+laAhhlsllhllGlh.lPh.shpcsQLYPKs..p.QlphposLAPYDRGGlPLppPuslKuQYPp.pPhlGhlTAYLoPluhalu-pThYhGTTIVSpPGGIlDEILYYTRGhDTVLESSILhhuFsIhSaLahscs	.h.pls+lWNhLSpPcslsRlFAhhlslllllGlh....lPh.shsssQLYPKsh.QpQl.hcoPLAPYDRGGlPLccPAslKuQYPpapPhlGpITAYLoPlAhalucpThYFGTTIVSoPGGIlDEILYYTRGhDTVLESoILhlSFhIhSWlahN+.s.	0	5	11	17
+9712	PF09880	DUF2107		Predicted membrane protein (DUF2107)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4038)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.50	25.50	26.30	46.90	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.51	0.72	-4.09	7	32	2009-01-15 18:05:59	2007-07-30 15:50:03	4	1	32	0	21	28	1	73.70	52	88.98	CHANGED	hYsGhhllIlGolusshGPtspDPlhRhlNhElPAhGVsLlhLuYNcsLALlTFluVsslhThVLlRAIlR.Etht	.hYlGhhLlIlGoluslhGPts+DPlhRhLNhEVPulGVsLIFLuYNcTLALhTFlAVsAllTLVLlRAIl+.EEh........	0	5	11	17
+9713	PF09881	DUF2108		Predicted membrane protein (DUF2108)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4039)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	29.00	29.00	69.70	69.40	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.15	0.72	-4.16	9	32	2009-01-15 18:05:59	2007-07-30 15:52:31	4	1	32	0	21	29	0	72.30	44	80.92	CHANGED	M-hLs.lluhsssll..GuluslLtpcslsKlIhhullpuGhlsllsuttYLDVAhssuLl-PluTIllLlhhhK	.......h-lLs.l..lussssll..GulGsIlpscslsKIIMhulL-uGhlslIsuhhYLDVAhluulh-PluTlILLlulhK.	0	5	11	17
+9714	PF09882	DUF2109		Predicted membrane protein (DUF2109)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4040)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	23.10	23.10	89.40	89.20	22.30	21.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.46	0.72	-4.04	10	32	2009-01-15 18:05:59	2007-07-30 15:52:45	4	1	32	0	21	30	0	77.90	46	91.52	CHANGED	llplllGlIullsulRlhls+sRupKL.YLNslsFuIAuLIALhlcoPhGhlAAssYFIsSTloSNAIAaTlucl-ch	....lphllGlIullhslRlhls+sRApKL.YLsslsFsIuALIALYIcoPhGulsAhsYFIsSTlSSNAIAaTlsclcc.....	0	5	11	17
+9715	PF09883	DUF2110		Uncharacterized protein conserved in archaea (DUF2110)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4044)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.40	20.40	20.40	21.50	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.33	0.70	-4.72	10	44	2012-10-03 20:18:03	2007-07-30 15:52:59	4	1	44	0	33	50	1	227.00	42	95.66	CHANGED	lsTppalhG-sp-Rul-uLcohVpN-LG-LDVca.clulpcDsaspVTLsG-DsElAtNLLpEcaGElssph-s...G-lYlGpLpSas--GaslDl..GlsVplPuDEL.sLGp.......G...oPcQltcRFGLVpHLP..lRhlcspc......t.ApLo-pphD+La-Wp+..u.ssRlsVNSsTRuEl+uslNRAGHuRDIlslERLGLLEpuVVC+EcTDuPGllAsIGPYLpu.............Eltsl	.............................lshh.hl.GDs.-pul-uLcohlpNtlGDL-Vca.clulpccsaspVolpG-DpplutNLL+EEaGEls.clcs...G-sYhGpLpuhs-sGaslss..GhhlplPsDcL.sLG...........GsscQltcRFGlVpHLP..lchlpspc...............tupLo-cphD+la-Ws+..s.ssRl.V...NusTRucV+usls+sGHu+DlhplERLGLLEpullC+-sTDsPGllAsIGsYL..u.Eltsl.....................................................	0	5	17	26
+9716	PF09884	DUF2111		Uncharacterized protein conserved in archaea (DUF2111)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4048)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.90	20.90	21.00	104.00	19.90	20.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.72	0.72	-4.16	17	50	2009-09-11 16:51:47	2007-07-30 15:53:10	4	2	46	0	37	50	5	83.10	50	53.86	CHANGED	lHpLlstLPVThRStppsGlRlEcGcVlDcsYTGPVLEpVLcsucll+ssP.sGsYcGlPVlVuPI+sc.GclluAlGlVDlsu	..lHpLls.LPVThRS+s+sGVRlE+GcVlDcsYTGPVLEpVlcpucll+ssPhpGsYpGlPVlVsPI+sp.GcVluAlGlVDlTu.	0	9	22	29
+9717	PF09885	DUF2112		Uncharacterized protein conserved in archaea (DUF2112)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4050)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	168.70	168.50	20.10	17.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.65	0.71	-4.53	18	54	2009-09-11 09:55:49	2007-07-30 15:53:23	4	1	50	0	40	52	5	144.40	58	92.47	CHANGED	hKVhIYPsNSLILuDLVERFGHcPLshsppI+c+Vpsss........lDSPPhNlTsEDPK+GLKYAAlEVPSGVRGRMoLhGPLIE-AEAAIIlsc.us.............huFGChGCARTNELshaLlRcKsIPlLELcYPcs---uhphVp+IspFLcuL	.hKVFIYPsNSLILuDLVERFGHcPLsltptI+c+Vpssp........lDSPPlNITsEDPKKGLKYAAlEVPSGVRGRMuLlGPLIEEAEAAIIhpc.AP.............huFGChGCuRTNELshaLlRc.K.sIPlLElcYPps-E-uh.hVp+IspFLcuL.	0	8	26	34
+9718	PF09886	DUF2113		Uncharacterized protein conserved in archaea (DUF2113)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4051)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	19.50	19.50	19.50	176.30	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.02	0.71	-5.16	17	52	2009-01-15 18:05:59	2007-07-30 15:53:35	4	1	52	0	38	49	4	184.00	33	96.99	CHANGED	h.VEss.-ctGsphYccIhpssLpDLsLs+sIt+l+halcPctPlFlhsslh+psspsI+ltDlAslp.........spsthplpIs-EsYlsplLcpLWpphG+splcQPsRaplhlssshs........lt-hlVtDPpcsLhcclhDhh.RlhPEGFRVR+pshpssphshlASEcslpp-hh.chstchhcch.tttt	..hhVEst.-ctGtchYccIlpssLpDLsLs+uIt+l+hhhcPccPlFllullh+pssphIplpDlAslp........tspsthplpIp-EsYlspLLc+LWph.ucsplcQPsRapll..lcschs..........-hlVhDsccclhc+lhDhh.RlhPEGFRVR+.hhpspplshlASEcslccEhl.ccstchhccl.p..s....	1	8	24	32
+9719	PF09887	DUF2114		Uncharacterized protein conserved in archaea (DUF2114)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4065)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	612.40	612.20	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.35	0.70	-6.15	17	54	2009-01-15 18:05:59	2007-07-30 15:53:53	4	1	54	0	38	54	6	449.10	58	91.99	CHANGED	KP..YaIVASVElGNTTTKCILTuTNL-TG+oYllsKsV+MTRDVRsPKsGEElFG+Tl.GsELT+EuVuELV+DTLlcuhKcApLsIcpDLcFVVRSTGVsAuFsSP--VGphIhALAsGCLtAGVPP+KMTPsMohsslPc+lccaShhDKlhFDGAVsGVlPP...TGhEhVANEMEGELsTAGIK.GAKWTsVDFRNPClSlDFGTTLsGRITsD.....ppPYAKTlGNFCGLAGAIPDAIlRGoGlVDccsGsALDla.......tphptphspchsccYu-csH.EhIcIccVPtsRcRFGpVPVsscuAccuGlsLIGCDsGcNGSclscLpcIGt-lhccpultsLhtslDhVsAplshRLl-lAhccsll..pouIGlTGRAGIoGpKPcLIL-tlt-h.tlacpsp-clVFVDDGLARGAAlMARCMNSLGTPcsPlGGhRGGtCIhupRIKhp+	....pPYYIVASVElGNTTTKsIlTATNhcTG+TYllsKsV+MTRDVRsPK.GEcVFG+TlhGlELT+EuVuEhV+-TLlcuhccApLsIc.DLcFVVRSTGVsAGFuSPEEVGphIlALAsGCLtAGlPPpKMTPsMohpsl.PcclpcaShl-KllFDGAVsuVlPP...TGhElVANEMEGELVTAGIK.GAKWTcVDFRNPClSlDFGTTLAGRITs-.....spPYAKTlGNaCGLAGAIsDAIlRGoslVDc+sGsALDla.......tthptphspchsccYA-chH.-hIpIccVPpshcRFGoVPVsPcuAccuGssLIGCDVGcNGSclscLp-IGt-I..hccpslssLhsslDhVsAplspRLl-lAh-cGllptsouIGlTGRAGITGcKPcLILEtlp-h.tla.cp.p-clVFV-DGLAhGAAVMARCMNSLGTPcsPlGGpRGGtCILupRhKhQp..	0	8	24	32
+9720	PF09888	DUF2115		Uncharacterized protein conserved in archaea (DUF2115)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4066)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	51.60	51.40	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.12	0.71	-4.14	19	67	2009-01-15 18:05:59	2007-07-30 15:54:01	4	1	42	0	51	66	4	160.70	27	89.85	CHANGED	hspp-LhphLtcpsppaolhDLhphpshhcc-hchlPtcYRcchhpshhphhhtsapcl+s..psss.hpspc..hDptphpchhshl....tptp.ppttpt..........h.hlhhllssYhhFlpccPhHPVGh.FPGGhpV.c+sGsYYCPl+-+pp-schulCpFCsu+pss	...........................ppt-LhphLtcpstphSlhDlh.hpshlcp-hphlP..ppY+cphhpt.hhphhhpshpcl+p..ppspthp.tp..h-tcphpchhshl....tp.t.pt.ppstcpp..........applh.hllssYhhFlhccPlHPlGh.FPGGhplhcc....sspYYCPl+c+..ppc.thulCpFClscp.....	0	10	36	46
+9721	PF09889	DUF2116		Uncharacterized protein containing a Zn-ribbon (DUF2116)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4068)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.  Structural modelling suggests this domain may bind nucleic acids [1].	21.80	21.80	21.80	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.22	0.72	-4.17	9	52	2012-10-03 10:42:43	2007-07-30 15:54:15	4	3	49	0	35	57	35	54.30	30	67.66	CHANGED	EsH+HCllCGtuIP.-EphCS-+CpEtapp+pK+hh+pp.Ihashhllhlulahhhsah	......H+HChsC.G.tsIP..s.....-..csFCSpcCccpatpcp++.h.p.p.hhhhhhhhhlhhhhhh......................	0	8	21	31
+9722	PF09890	DUF2117		Uncharacterized protein conserved in archaea (DUF2117)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4069)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	29.00	28.30	20.80	18.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.46	0.70	-5.14	16	49	2009-01-15 18:05:59	2007-07-30 15:54:38	4	4	43	0	37	49	2	210.00	37	57.38	CHANGED	sDllsLLNaGKohpTG+sFGchVssR.....st.c.KPLIQIERPGpsDGslIsWN.......cts...pshs-cLScpLsLsh.p........hppslsptpshppsp...plhR+lsGV.PGEsIhVNGIVIG+AsSscVplluEN.GhlssIpGGpIKcHGlEKLtc......VDLp+AhVKTG.hlR+ss........hpschhc.cshstch..............s+VllIDHAAEcshEhh..csAshVlTlGDDTTsIuGD	........................................................DllhLlNaGKSt.TG+sFGphVspR..................sthpcPlIQIERPGctDGslI.WN......................pts...pshscpLocpLsLp......................ppslspthshh.ppp.....phhRclpGVpsGEsIhVNGIVlG+.upuscVtllucs.GhlscIhGGplKcHGlEKLtp......lDLpcAllKTG.hLRRps...........hpschtp.....pshspph.............................sclshlsHAuEcsh-hh....cc..sshVlTlGDDTTtlsGD...................................	0	10	21	29
+9723	PF09891	DUF2118		Uncharacterized protein conserved in archaea (DUF2118)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4072)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.64	0.71	-4.50	9	43	2012-10-02 20:27:15	2007-07-30 15:54:49	4	1	43	6	31	71	34	148.80	31	94.63	CHANGED	h+lP+lYVEstts-................t.cVhlcps-chhhah-cscthhh.GKslYph.hc-hsD.lhtp+hp+chlIhhP..DtRphlalKcGocLh.lPsEGapVs.IschGsRVtcGsslAslpT+KG-lRalcuPVsGsVValpE.Ps....tRssYlaYIlPE	............................................+lPcLYVEs..p-.................s.cVhlcpstph.....tF.....l-h...s.c......thhhtt...KhlYch.acpas-.hhtsph.ppDhlIhhP............ct+phhal+cGsc.Lh.lPsEGapVh.IsshGsRVccGctlAslpT+KGE.lRal+sPhsGsV..lalpEhss....tRspYlaYIL.E...................	0	10	13	21
+9724	PF09892	DUF2119		Uncharacterized protein conserved in archaea (DUF2119)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4073)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	29.60	29.60	29.60	144.90	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.16	0.71	-5.02	10	27	2009-01-15 18:05:59	2007-07-30 15:55:00	4	1	27	0	18	26	2	196.00	39	94.08	CHANGED	YupG+t..Ph+LFVAGlHGsEuKsToclLcclp.schp.....GslsllP.lVcsuKYISTLcPcYYco.hGKpILclIEch+P.-hYlELHSYStENacKLTupsRhsptGVPsalsLpsGVLlGSVSPhlR++hFs+-sLCLTlElP.............pttspcut-hlsclLclltcupoR-EFIEclc++YPcpscKAhchh+cFaGp	....h.spucs..Pp+LFluGlHGsEuKhTpplLcplp....sphp..................Gplhlhs.lscp..o+YlSTLs.cYYcop.GppllclIEcYcP..chYhElHsYstcsYp+LTshcRhsppGVPPhl-LssGVLluSVSPhlRp+.Fpc-slChTlElP..................shpstcshchhhclLchhhpupsR--hhcclhpcYPcpscpAhphu+caah...	0	5	11	14
+9725	PF09893	DUF2120		Uncharacterized protein conserved in archaea (DUF2120)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4077)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	39.30	95.70	22.20	20.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.82	0.71	-4.25	6	27	2009-01-15 18:05:59	2007-07-30 15:55:13	4	1	27	0	19	26	2	138.80	38	95.54	CHANGED	lpcl.............hG+IMctl-AF+GSKPllcscElLhVRGhsR......DchhcchsSlhEaL....l-hLsccGhELls-h.............DEh...Vp......chsElhs-o-ha.D.hGFE+lKcoFEshGCssDYslG+p.cshhlhlsMWhDKsuhsPKFVEllsl	....................lhG+lMpph-AFKGSKPlhcp-plLhVRGlsR......Dc.hcchssIc-aL....h-pLsppGhElhsc..............D-h...lp......cIsE.lhs-.osha.DtaGFEtlKcuFEshGCcsDYtlu+K.sslhlsluhWhDKpshsPpFVEVhs..	0	4	9	15
+9726	PF09894	DUF2121		Uncharacterized protein conserved in archaea (DUF2121)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4079)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	26.20	26.20	141.40	141.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.09	0.71	-5.02	13	34	2009-01-15 18:05:59	2007-07-30 15:55:24	4	1	34	0	25	33	2	194.40	38	71.02	CHANGED	MSLlIuYhGKNGAVlAGD+RpIhFpGpcpsREcLEEcLYSGcI+oDEELtK+AsEauVp...IplsDs+cKVpplss.VLsGEVsol.Gt-oKRRRlYsTpGshsIl-lpssplTspohssGosllVFGN+asKclsppplK+php..hKhslccltclhcclhcpl.tcssTlScpa-lhhspsttcshct......sIc+Dlpc	MSLlIuYhGKsGAVlAGD+RpIhFpGscppRcpLE-cLYSGcI+oDEELh++AcEhGlp...lpIsDsccKV+clus.lllGEVpol.uh-oKRRRlYsTpGshsIl-lhssplsspphtpuusllVFGN+asKclupcpl+cphp...phslpcltclhcclhccl.ppTPolSppa-lhhspsthsshct......slc+Dlp.p.............	0	6	13	19
+9727	PF09895	DUF2122		RecB-family nuclease (DUF2122)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4080)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	61.30	61.00	23.50	18.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.21	0.72	-3.84	18	59	2012-10-01 22:53:19	2007-07-30 15:55:36	4	1	58	0	37	53	0	105.40	35	71.33	CHANGED	GuAAQpGlP-lhKLAhKhGp.sllVlsDlcDAlElL+P-hVhhlspsspctt.........phhc.........hcs+lhlVhsGu-.suhochElshGpslhhtulcp-lGslGtlAlhL..Ypl	.GuAAQsGlP-lpKLAhKhsK.slllLs-lcDAlElLcP-hlhhlupsuppphp........p...hp.........hts+lLllFsGs-.sGFoKhElph.Gptlhl.tlpp-lGulu.hulhLYp....................	0	13	19	28
+9729	PF09897	DUF2124		Uncharacterized protein conserved in archaea (DUF2124)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4090)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	21.40	21.40	22.30	142.70	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.52	17	49	2009-01-15 18:05:59	2007-07-30 15:56:01	4	1	41	5	34	50	1	147.50	38	93.47	CHANGED	+GlushLpsFKshl....t.psucpI.sahGssGsCsPFApLhuYulRsh..pphFlPssch-cu+plp.lsclGhp...ls-.hshc.sDhlVlhGGLAMPchsloh-csppllpclsstp....llGlCFhshFp+sGW.cpIsFDhlIDupl-.Vpl	..+GlushLcsF+shl....t.psucpI.lahGosGsCsPFApLhuYulRsp..cthFlPssch-cu+plt.hsslGhp...hs-ttshc.sDslVlhGGLAMP+hslss-clppllpclsscp....llGlCFhuhFp+uGWtcc..IcFDhlIDuplc.V......	0	8	22	27
+9730	PF09898	DUF2125		Uncharacterized protein conserved in bacteria (DUF2125)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4093)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.40	21.40	21.40	21.50	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	312	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.74	0.70	-5.12	45	259	2009-01-15 18:05:59	2007-07-30 15:56:21	4	3	225	0	86	216	94	300.50	20	82.17	CHANGED	WahuAstlcpshssWhspppupGhts-hushs....lsGFPhRhclphsssslusP.........psGhuhpustlphhu.sYpPs+llsphss.stplshs......stsasltpss.....hpushshsspssLsh-chslsstshshsssh..t.......sshsplp....hthtps..ssssshchslpspshshssshh................thpshphcuplphshs........hshsslpptpspssplclppsplph.Gshtlpu.uGslslDssGhssGclslpspshcpllshhtpsthl.t.....................................t......shpsshshhuthsGptp.slslsLphpcGplhl.GslPlGtsPs	...........................................................................................................................................Whhhustlctthps.hsp.tstGhtspttshp....hsGaPhRhplhssshphtps..........tpuhshphsthpssu.hatPhplhhthsu.Pthl.....ph..s.............hthshshhpss........hphthsh.s.chplshcssslshts.ssths............sshtchp....hp..hs......ssssshc..hth..p...hsshshssshh..........................shttsphsushs.hslssh...................................ss..p...th..h....t...p...h.ps..t...s...l...s...lpphplsh.usht.hsu.oGshsls..p......s.......G.........h........hs..GclpLplsshpslhpsht.tst.hps........................................s...........shpsh.hthhu..ths..t.st..........s...shshsltl.p.cGph.h.G.lslGthP................................................	1	20	55	65
+9731	PF09899	DUF2126		Putative amidoligase enzyme (DUF2126)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4196)	Family	Members of this family of bacterial domains are predominantly found in transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown, but they are likely to act as amidoligase enzymes [1] Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes) [1].	18.40	18.40	35.20	26.50	16.30	17.50	hmmbuild  -o /dev/null HMM SEED	819	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.43	0.70	-13.37	0.70	-6.51	40	471	2012-10-02 17:21:26	2007-07-30 15:56:54	4	7	408	0	164	493	127	725.70	51	74.92	CHANGED	s-.sEV-Fpa-MpVsRltEsPRVTKPao--pWpslssLGcpVDtcLptsDVRLTMGGEPTFVSlDDh-usEWNTsAlGPsKRtLAssLl+RLRc+FA.PGGlLHaGQGKWYPGEsLPRWuhulaWR+DGpPl..W+ss..sLlAc-s....psts....ssscpAcpFlpslApcLGlsschlhPAYEDshaalh+EspLPsNVDP.tcu+Lc......DsppRtRls+VFccGLspPsGaVLPlp+hp.spss......WpSstWhhR.+s+laLlPGDSPlGhRLPLsSLPalsss-aPa.hh.tDPhpspssL.....................tttt.ssststptstpphtpth..........................thVRTALsVEsR-G+LpVFMPPl.-p.lE-YL-LluulEssApplshPVhlEGYsPPp.DPRLshl+VTPDPGVIEVNlHPAsoWcEhVchTpsLYE-ARpsRLGoEKFMlDGRHTGTGGGNHlVLGGsTPsDSPFLRRPDLL+SLltYWQ+HPSLSYLFSGhFIGPTSQAPRlDEARcDuLYELEIAhuQlPts...tsspsP..PWLVDRLhRNLLsDlTGNTHRAEhCIDKLYSPDusTGRLGLlEFRuFEMPPcsRMSLAQQLLlRALlA+FWcpPhcs.tLVRWGTsLHDRFMLPHFlhpDFtDVlsDLptsGasFcspWFssahEFRFPhhGclph.pGlcLELRpALEPWHVLGEEuusGG.TsRYVDSSlERLQVKlpGhss..sRaslsCNGRplPLpsTGssGEhVAGVRY+AWQPsSuLH.PTIslcuPLsFDllDoWsuRSlGGCsYHVAHPGGRsY-TFPVNuhEA.EuRRlARF.shGHTsGths..........................ss.tp.....ssEFPhTLDLR	...................................................-.s-spFpap.pVsRlhEsPRVT+PYo-ppWptl.tLGppVDtpLttsDVRLThGGEPTFVSlD...Dh-usEWNTsAhG........PpKRthAspLhpRL+sc.au.s...sGhlHaGQGKWYPGE.LPRWshulaWRpDGpPl..Wpss..sLlAc.t...ts.s...........................hsstpApchltslAttLGlssphlhPAYEDshhaLhcEtpLPs..s..lss......s.....s.c..Lt..............................-....p..Rtclt.chhppuLspssGaVLPlpthtst.t................WtSstWhhR.ct........+hhLlPGDSPhGhRLPLsSlsahs.t..p..h.h...h.tDPhtstssL.................................................................................................................................................................................t.hsRTALssEsR..................s.....................Gh..................LhlFhPPh..pt..lEcaL-LluslEssAp..pls.h.s.l.llEGYsPPt.Ds.RLphhplTPDPGVIEVNIpPutsWpEhsppTphLY-pA+.sRLsoEKFhlDG+HsGTGGGNHlslGGsTPuDSPhLRRPDLLtSLlsYWppHPSLSYLFSGhFIGPTSQAPRlDEuRp-sLYELEIAhupl.t.........................st.pss..PWllDRlhRpLLhDlTGNTHRuEFCIDKLYSPDus.oGRLGLlEhRuFEMP.PHs+MulsQpLLlRALlAhFWcpPhps.....LhRWGTtLHDRFhLPHFlhpDhtDVls-Lpt.tGasFcspWFssahEFRFPhhGphth..pG....lplELRtAlEPWHVhGEEus..suG.TsRYVDSSlERlQV+lp....G...hss.........pRa.lloCNGh.lPLpsT..s.psu.phVuGVRa+AWpPsSuLH.PTIsVcuPLsFDllD.s.......Ws.....tR..........SlG.GCpYHVuHPGGRsY-ohPVNuhEA.EuRRhsRF..shGHTPGt..hs......................................t........s.-hPhTLDLR.............................................................	0	45	105	133
+9732	PF09900	DUF2127		Predicted membrane protein (DUF2127)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4331&COG3305))	Family	This domain, found in various hypothetical prokaryotic and archaeal proteins, has no known function.	24.30	24.30	24.60	25.50	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.51	0.71	-4.15	33	344	2009-01-15 18:05:59	2007-07-30 15:57:02	4	2	332	0	92	229	22	140.60	28	75.50	CHANGED	tuL+slAlhEusKGllslluGluLhslhtps..lpphstpllp+.........hplsPssphsshh......LphssplossslphluhhshsYuslRhlEAaGLW+s+tWupahullSuulYlPaElYElhp+s.ohhphslhhlNlhlVsalhhplt	.............................................................h.sl+slulhcus+ull.lluululh..h..ltspp..lp.thlpcllph.........hplsssshhsphh......Lctutt.lssssLt.hsushhhsYusl+llEuhGLW+t+hWupahullusulaLPhElY-....lh.p..ph.ohhplsshhlNlhlVhhhhhph.............	0	30	61	81
+9734	PF09902	DUF2129		Uncharacterized protein conserved in bacteria (DUF2129)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4471)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. Structural modelling suggests this domain may bind nucleic acids [1].	22.00	22.00	23.90	22.40	20.20	18.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.33	0.72	-4.18	38	1016	2009-01-15 18:05:59	2007-07-30 15:58:04	4	2	1011	0	95	365	0	68.40	38	76.10	CHANGED	RpulIVYLaplKps+.pLR+aGslhYhS++h+YllLYlsp-cl-plhcKlpph+FVK+VchSh+s.lcpsap	..........RpullVYLhh.+ct.+.pLp+YGcIhYhS++h+YlllYlspp-l-plhp+Lpch+FVK+VchSahptLcpsa.............	0	22	48	71
+9735	PF09903	DUF2130		Uncharacterized protein conserved in bacteria (DUF2130)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4487)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	24.70	24.70	25.20	26.30	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.55	0.70	-5.65	42	737	2012-10-11 20:44:46	2007-07-30 15:58:23	4	1	708	0	105	513	324	259.60	43	60.52	CHANGED	-...c.hhpch-pp...lcphpcpI-clK....chttphSsphhGEsLE.ahEs........hhtsuF...PpshhEcssc.uppGu.....KsDaIaRshs.......ppspchsSIhaEhK.......pTKphs-calc+LccDppppps-aAlLVS.l.Pc.......hhV-s.tthcphaVs+PphFlslhslLRpuhlphhph+ppht....hhpspth.lhpF..csphcphhpuhscsas.hpcchppthcpIsKthp+hpcph-slltuspsLphuppphssholpcl..sthpsshttc	............................hp....sthppphEsp.LKsts-plEh..hK...shK..sQtSo.KhlGEoLE.asEscFp........phcphuF....Psuh...F-KDNK..uspGo...............KGDaIaRtpD.......csGsEhlSIMFEMKNE...cto..csK+KNp-FhKcLDcDRREKsCEYAVLVThLEs-s.phaNtGIVD.so...H...p..YEKMY.....VlRPQ.aFltllulLRsuulNoh..+hK..ppLt....hh+EpNh-locF..Ec-hcshppAhsKsYpssopsatculccI-KslK+hEcs+chLssocspL......+hAs.NKlps.lol++LsptsssMtt......................	0	29	63	90
+9736	PF09904	HTH_43	DUF2131;	Winged helix-turn helix	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4519)	Family	This family, found in various hypothetical prokaryotic proteins, is a probable winged helix DNA-binding domain.	21.90	21.90	22.20	23.00	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.09	0.72	-4.18	22	301	2012-10-04 14:01:12	2007-07-30 15:59:03	4	2	275	3	56	190	6	87.40	50	91.47	CHANGED	SKopsuFhRRLYlAaLI-sspt.sVPuLhchTGMPRRThQDslsALs-lsIcspF.Q.cGtRppsGaYpIpsWGsIsctWlpp+lppIppsL	.........chpssFhRRLYLAhLl-stcpsNVPcLhctTGhPRRTlQDslpALs.slG.IplpFVQ..-...GtRpNsGYYplsDWGPlDppWltcphppItus..................................	0	5	17	37
+9737	PF09905	DUF2132		Uncharacterized conserved protein (DUF2132)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4628)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.50	20.50	22.00	36.70	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.13	0.72	-4.01	80	623	2009-01-15 18:05:59	2007-07-30 15:59:32	4	1	484	1	182	464	52	63.70	59	64.05	CHANGED	QsNNPLHGloLEpllscLVcaY.GW-tLupplsIpCFpscPSlKSSLKFLRKTsWARcKVEsLYL	..psNNPLHGloLEplLscLV-aY.GWctLupplpINCFps-PSIKSSLKFLRKT.WAR-KVEsLYL.	0	44	101	146
+9738	PF09906	DUF2135		Uncharacterized protein conserved in bacteria (DUF2135)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4676)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	22.00	22.00	22.10	22.40	21.90	21.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.40	0.72	-4.01	24	419	2009-01-15 18:05:59	2007-07-30 16:00:37	4	15	368	0	47	179	49	47.80	72	16.17	CHANGED	PhpGsYhVaVNYaGstssp.............thsssplsllos......Es..oPsEc.pcsahlPl	..PlHGRYQVYINYYGGRSET......................ELTTAQLTL..ITD......EG...SVNEK.QETFIVPM.......	0	7	24	37
+9739	PF09907	DUF2136		Uncharacterized protein conserved in bacteria (DUF2136)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4680)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.80	20.80	21.00	21.30	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.40	0.72	-3.90	64	642	2009-01-15 18:05:59	2007-07-30 16:00:53	4	2	550	0	147	444	36	75.70	38	75.54	CHANGED	cucpsLpsWaphscpApWpsPp-lKppa.ssAshlt..sp+hVFNItGNcYRLIstlsa.....phphlal+alGTHsEYD+ls	........................p.tchsLpshhshlp+upappPp-lKpha.sShDth.+....scahVFsluGNphRLluhlpF........ptp+hal+alsTHtEYD+l........	0	31	94	128
+9741	PF09909	DUF2138		Uncharacterized protein conserved in bacteria (DUF2138)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4685)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.70	20.70	21.30	22.00	17.70	20.60	hmmbuild  -o /dev/null HMM SEED	555	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.85	0.70	-6.37	14	352	2009-01-15 18:05:59	2007-07-30 16:01:41	4	1	334	0	18	175	9	509.80	80	97.64	CHANGED	KtWthhulls..AlslluusVhtlta.....tspusc+sLss....sslpl........DLscPDullDScSLSQLPKDlLpVPhL+DVLTEDFVFYYpscuDRLGlpGoLRRIlYEHDLsL+DpLlcpLhDQPApVALWRusDG+LpaahllhpRuGLAKlLEPLuhsAsuDuQLSKsthu...lsusslPVYpL+Ysus+sLhFAocsD+llsLSsPsMLacc-.......tp......sscAsslhusLLuG....+chaspuFGLts+ssp..PspQRlVVSAshLuFGYQRahPuFAGlRF-hG.s......sG...WpSalALsD.stplstpaDFsPlWpAMPuGAShCVuLPhsathApshLs+luuE...ssphs.......-tLsGsAGlCWYucS+LhoPLFVuplcusstt...chsptlGKLFspsIGAaEuKAsc..........thLPVoppppG.puplWpRpVSSRaGpYssupAspPsQL.u-hFFpVoLAhpspTLlFSLDDpLVscALssLsKpaPAhuDVlPpD..ullPLYlsPpuhApLlcpEThsSLPpDhEPVFhNAAQThLhPKLcALuphspYsLsLspshpsuuuWQWLPlpW	......................KGWRFYGLVGFGAIALLSAGVWALQY.....AGSGPEKTLSPL.VVHNNLQI...........DLNEPDLFLDSDSLSQLPKDLLTIPFLHDVLSEDFVFYYQNHADRLGIEGSIRRIVYEHDLTLKDKL.FSSLLDQPAQAALWHDKQGHLSHYMVLIQRSGLSKLLEPLLFAATSDSQLSKTEISSIKINSETlPVYQLRYNGNNALMFATYQDKMLVFSSTDMLFKDD..........QQ......DTEATAIAuDLLSG....KKRWQASFGLEERsAEK..TPVRQRIVVSARLLGFGYQRLMPSFAGVRFEMGN..........DGWHSFVALNDESASVDuSFDFTPVWNSMPAGASFCVAVPYSHGIAEEMLSHISQE....NDKLN.......GALDGAAGLCWYEDSKLQTPLFVGQFDGTA.....EQAQLPGKLFTQNIGAHESKAPE.............GVLPVSQTQQG.EAQIWRREVSSRYGQYPKAQAAQPDQLMSDYFFRVSLAMQNKTLLFSLDDTLVNNALQTLNKsRPAMVDVIPTD.....GIVPLYINPQGlAKLLRNETLTSLPKNLEPVFYNAAQTLLMPKLDALSQQPRYV..MKLAQ.....MEPGAAWQWLPITW.......................	0	3	7	13
+9742	PF09910	DUF2139		Uncharacterized protein conserved in archaea (DUF2139)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4697)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.90	25.90	26.30	26.30	20.00	25.80	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.03	0.70	-5.41	6	35	2009-01-15 18:05:59	2007-07-30 16:02:18	4	1	31	0	24	37	0	292.40	40	66.93	CHANGED	LYaTLAFEAcAaFIc.ssspc+lY-FpLVGstPsSGGDTYNAVEsVD-hIYFGGWVHAPAhaRt+scG+.AsIsFoNKYSHVHcYDTusscV+LlWKEShHc.ccWAGEVS-IIYNPYsDcLLLARtDGHtNLGVYpLD.RRGtsR+L.scPuhKGshhhDhAhFul.+pahtGhpGlcslDLlot+h....EtFs.us.SlDGGshhpP+lGuh.sSlasRlFAFV+GGlhVhNPa.GEcatFVRLhDFs.ohYuPhRsNALslGGGlLluFNuapcAshRsssE.tplhp+hTNTlluPSlLVYIAPPhVKIVGuFGARlTSlEthGsKlLlAsNTsPNstthD	..............LYaTlAFEupAaFl..pssucplYcFchlGpsPsSGGDTYNAVpsVD-hIYFGGWVHAPA.hactcs.php..thI...sFpNKYSHVHtYDhcsspVcLLWp-uhHc...c...pcWsGEVS-IlYDPapDcLLlARtDGHtNLGlYplshcsGchchLsppPoh.KGshhcDhAhF.sl.hps.........appGlptltshDhlst+.h.....-tFs.hut..ohDGtshlt.thGsh.soh.NRhaAFh+GGlhluNPh.t..-phpFhRLhDF..s.huPhRsNsh.huGGllhsaNuapcuhhpshp..t.h.hthoNslsuPolLlYlsPP.s+IVushGARlTShp.htscllluhsThsNhtth..........................................	0	10	12	17
+9743	PF09911	DUF2140		Uncharacterized protein conserved in bacteria (DUF2140)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4698)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.90	20.90	20.90	21.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.07	0.71	-5.12	28	414	2009-01-15 18:05:59	2007-07-30 16:02:32	4	2	407	0	70	269	2	183.70	34	90.22	CHANGED	NhWKhuFhs...LLAl.lhshshlsstlhtPs.p....ptsspppscucs.shslsosKcpLNpllspYLpcht.ssphsYchhl.ssplhlpGshplhGpslshhlhFcPpVhcNGsVhL+spslSlGsLsLPlshVLpYlppsYcLPcaVslpPccpplhlpLschchpsshhl+AccIDLhsD.cIpFslhlP	......................................................NhWKhsFlh...L.lul.llusssh...lssplhpsp...c.........tpts.sht..pppups.shsls..osKpplNp.llstYLp-ap.....s.pcl..p...Y.+hhl.sspshhpGohplLGp.slshhlhFpPhV.h.cNGsV.pL+spslSlGsLsLPlp.VLpalcpsY.+LPcaVplssccpplhlpLsphchpsuhhl+AcpIsLh.sD.cIpFslhh.............................................	0	18	43	59
+9744	PF09912	DUF2141		Uncharacterized protein conserved in bacteria (DUF2141)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4704)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.00	21.00	21.10	21.30	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.49	0.71	-4.41	90	328	2009-01-15 18:05:59	2007-07-30 16:02:53	4	6	253	0	136	354	294	108.70	26	65.11	CHANGED	Vplsslcss....pGplhlulass..scsa.......ptppshtstpspsss..sssplsFpsls.sGsYAlulhHDpNuNG+hDpsh.hGl..PpEsaGhSNNsp..hphG......PPsFpcut.Fsls.ttspslsI	.............................................lplpslcss.pGplhlslass....tpsa.............ttppsht...th...ps.tsss....sshplshpsls.sGpYAlslaHDcNsNs+lDpsh...hGh..PpEsaGaSssst..hh..h.G......sPsapcutFtls..tstph.........................	0	45	93	121
+9745	PF09913	DUF2142		Predicted membrane protein (DUF2142)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4713)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	24.10	24.10	24.30	24.30	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.44	0.70	-5.80	34	382	2012-10-03 03:08:05	2007-07-30 16:03:08	4	2	312	0	85	365	107	367.10	17	74.57	CHANGED	l..hhuhhhshssPshpsPDEshHhs+sh.......tl.sp...G.h......hssspsph.t.......................thttshhthhsptss.st.pthtpsshspptsshsph.s......YsshhYlstulGhhhuphlshsshhslhhuRlhNhlhashlhhhulthhsht+..hl...hhhluhlPhsla.suShssDuhthuhshhhhuhhlph....hhppphsp+...hhhhllsssLlshsK...ssalhLshlhhhls.......ttthspct......................................hhsthhsshhhslshhhhhths......pth.hhtsth............stslthllspshthht........lhhpsl.....h...phhsstF.....hGWhcs.l.s..hhhshhhslhhlhhsshsthph+.........phhhhhlslsshhhlhhhlhlshosssssh.......l.G........lQGRYalP...lhhll	.......................................................hshhhhh.h.P.....hp..s.P.DE.hHh.psh.................tl.sp.....................................hspstt.t..............................................h.ht.......t.t.t.....t.t...ht.t.h..t.t....h.sh...p..t..h..s....s..................h.shhYlspulGhhl....uphl........t..........hs....h.....hhh.h....hhuRlhNhlh...ah....h....h....h...h....h....u..l....+h....h.......ht+........hh..........hhhlull....Phsl..........s....u.ShshD...shs.h...shshlhhuhhhph............htppphstp....phhhh.hlhsh.llshsK.......hsahhll...hL.hh..hls.................hp.h.httpt.....................................................................................hh.tthh.hh.h.h.hhlhh.h....h..h.hh.hh.....................h...hh..t............................ttp...h.t..h.hltp.h...hht.............hhhpsh......................h.s..h.hhs.h......h.hGhhs.ht......l..sh..h.hh.h.h..h.......h....h.h....lhhl.hh...s.thp.ththp.............................h.ph.h.hh..hlh...h...sh..l.hhlhhhh...hls..as.shstsh.............h.G........lQGRYah.P.hl.h.............................................................................................	0	30	55	75
+9748	PF09916	DUF2145		Uncharacterized protein conserved in bacteria (DUF2145)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4727)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	25.10	69.70	18.30	16.50	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.25	0.71	-4.79	20	193	2009-01-15 18:05:59	2007-07-30 16:04:25	4	1	187	0	37	127	1	199.40	53	72.14	CHANGED	ctLsu....pGAcVsllARsGpDhSch..Gl+aoHsAaAlp...s.s-G....sWpVhpLhpcCss.spSpLap-GLu-Fah..-sshph-sulllPoPplQp+LlslLsosstt..tLHsspYSllAaPauocYQNsNpWsLElLAAAhtt...........sss...........RcpspuWL+.AtYpPssl+luhhpRLuuphhssslshcDHP.t.hhuGplpTsTssSlhpaL	.......QpLsu.psssVVILsRpGQDhSph..cLpaSHAGaAhR.....p.PsG.......sWRVaHpLNsCGT....AcSuLYhQGLhEFlu..DDLlspsluVlRPpu-lAsALpsLLpSuh+Ls.hhHuPRYsllAaPFSusYQNSNtWlLEVhAtA.-A.p...........lho...........RscA+pWLQhpGYQPSlVssGsacRLGA+LFsPNVaTDDpPuEhlhpGNlulsosDSVhcFl..............	0	8	23	30
+9749	PF09917	DUF2147		Uncharacterized protein conserved in bacteria (DUF2147)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4731)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	19.80	19.80	20.30	21.80	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.61	0.71	-3.82	158	1014	2009-01-15 18:05:59	2007-07-30 16:05:10	4	3	685	0	331	901	232	111.90	28	71.04	CHANGED	G.hWpT.......ststs..Vcltp.su.....up...lsGplhph..........................tpspsp.....hcspsllGhpllhs.hc...sssp........ap.GplhcPcsGKsYpuplpl.....pss..ppLpl+G..pluh..hls+o.QsWpR	.....................................................GhWpo.......ststs.....lcltp.ss......up.....hsGplhph.....................t.t..tppssss.........hcspshhGh.plltshct...sssp.........aptGplh-Pc..sGKs.Ypschpl.........pss....tpLpl+G...hl.u.h.t.hls+o.poWpR...............	2	94	198	252
+9750	PF09918	DUF2148		Uncharacterized protein containing a ferredoxin domain (DUF2148)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4739)	Family	This domain, found in various hypothetical bacterial proteins containing a ferredoxin domain, has no known function.	25.00	25.00	36.70	35.90	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.30	0.72	-4.25	11	138	2009-09-10 16:57:13	2007-07-30 16:05:19	4	2	131	0	61	116	3	69.00	55	39.09	CHANGED	-FsGPpCsh+hlDLGIAlGSAsKsAp.LslDNRlMYohGsuApphGhl.DA-llhGIPLSsoGKNIaFDR	............tGssCAhpslDlGIAlGSAsusAuplpVDsRVMaSsGlAApcLshl..-..sc..h..V...h.uIPlSAouKNsFFDR..	0	29	50	57
+9751	PF09919	DUF2149		Uncharacterized conserved protein (DUF2149)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4744)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	39.40	32.40	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-10.16	0.72	-3.89	29	201	2009-01-15 18:05:59	2007-07-30 16:05:37	4	1	172	\N	82	166	11	90.30	38	82.04	CHANGED	hsulsNLhDlhlVhuVuLllAlVhshsh.phh....sppshshhpssspsshphlh.+.cGpclcphp.otp....uuGpG...p+hGssYc.hcsG+lIaVP-	....ssVsNLhDlhhVFuVuLhlAlVhphshsphh....uppchshlc.s.sGcts.M..clls....K.cGpclpcapsopp.......uuupG...p+lGssYc.LcsGclIYVPE.....	0	31	68	77
+9752	PF09920	DUF2150		Uncharacterized protein conserved in archaea (DUF2150)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4749)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.60	20.60	103.70	103.50	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.27	0.71	-4.70	14	47	2009-09-11 15:57:27	2007-07-30 16:05:50	4	1	47	0	36	48	0	187.60	39	94.39	CHANGED	hpFYopERWpNWlsplcEsch-..s-s--suc...lhhshpDDlslAllKIlstacstpl.sc--AlscLcsl+-IVhs-st......sEDh..ll-ulQsSLlslFhAucpYltGshs.-sslcphlcsAhcAEt.--Dl-pALshsuphGutVIsGcshstchlcD..hphGLVsEWlsGlDolpsAhssscsh-E-	..pFYopERWpNWls+lcEp-h-...sEsE-su+...lLlNhpDDsslAlhKIlsta-cspl.scE-AlccLpsl+-IVLsEl-......cE-pshll-uVQTSLlslFhAAEpYlsGshst.-uslp-hlcsAs-AEt.-EDlDsALshsupsGstVlsG.ccLshphhc-..hpYGlVsEWlsGlDSlpuAMsss-sh-E-.......	0	6	29	34
+9753	PF09921	DUF2153		Uncharacterized protein conserved in archaea (DUF2153)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4755)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	23.00	23.00	23.40	103.20	22.20	22.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.53	0.71	-4.52	8	41	2009-01-15 18:05:59	2007-07-30 16:06:01	4	1	41	0	26	34	0	125.30	47	88.22	CHANGED	sL-pWVKhQKplLcolcsh-..EchcsuDRL-LIluoRsAFpHMhRTLKAFDpWLQDPhlluHMPREMLhDVpsshhclhppLLELDI+HTSpa+-LlpKhu+EGKLsPllhhh+..stpcPsRR+cu	..pL-pWlKhQ+pllpsLcchE..-phc..s..hDRL-LILuoRsAFQHMhRTLKAFDpWLpDPhlhpHMP+EMLc-lcsphh-lL.cLlELDIcHTSpaR-hlsKhuKEGKLsPllhh.h..ppppspRcp..t.............	0	9	14	19
+9754	PF09922	DUF2154		Cell wall-active antibiotics response protein (DUF2154)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4758)	Domain	\N	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.37	0.71	-4.39	37	1584	2009-01-15 18:05:59	2007-07-30 16:06:22	4	7	1195	0	260	904	13	106.40	24	44.17	CHANGED	thhGstpphpp..sapacDlNltshhGcshIDLspshlsps-ssIhI+phhGsscIlVP.DlsVplct.oslhGslphhsppp.tl.Npslphpossappst+clKIhsslhhGslEV	...............................hGp.ph..p..shph.cDlplpthhGcspIDLspsh.h.p....cp...s...s..Ih..lcthhGssplhVP.hc..hp..V..sLc.s..ss.haGssp..........t..p.....t....t..h.......p.....php...pt.h..............s....h.plp..lhhshhhGsl-V..............................................	0	99	190	227
+9755	PF09923	DUF2155		Uncharacterized protein conserved in bacteria (DUF2155)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4765)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.30	21.30	22.40	22.50	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.12	0.72	-3.88	47	322	2009-01-15 18:05:59	2007-07-30 16:06:44	4	3	319	0	107	251	923	91.50	43	52.17	CHANGED	AslpuLDKloGcsp-l-ltsGcssphGsLpVslptC..RhPs-.sPsssAFstl.........slpcpspst.......lFsGWMhASSPuLsAl-HPhYDVWVhcC	.........................................................AhhpuLDKITG+h.psh-lhlGE.o.spF..G.u.Lplss+sC........hp......R......sssE.sspssAFlpl..................Tlscphpc.........lFsGWMaAsSPuLsulEHPlYDVWlpcC...............	0	32	66	79
+9756	PF09924	DUF2156		Uncharacterized conserved protein (DUF2156)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4866)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	27.20	27.20	27.40	27.20	26.50	27.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.65	0.70	-5.60	156	2342	2012-10-02 22:59:21	2007-07-30 16:07:05	4	28	1932	2	547	1913	59	286.60	23	38.43	CHANGED	ttllppts...tpshuplshhpcpphhh.s....ssp....uhlha....thpspshlshusPlG...s.....pphsphlppahphuppt.uhtsshYplstchhshhpc.hG.....hphh+lGp-sllslpsa.sLs..G++hpslRptlN+hc+pG..hs..hchhth.....sphhscltplucpWhpt.c..........pE+sFohuhhctthht.p..hthsl..lcs..-G................................clhAFsshh.sht....psshslDlhRtpsc.uspGhh-hlhhph...hthhptpG.......hphhshuhushtth...t................................t+hhthlh..tpphashpGLRpaKtKapPpa.ts+Ylsh	........................................................................................................t...htphs.sssh.u.thhhht..D.+th..hh..s............ssp.............uhlha......phpss..t...hl.sh.G-PlG........st..............pph.t.ps...l.ptFhphsc.ph...u..hpss.ahp.lspp...hh..h.h..pc..hG.........................hphh+lG-..Eu.ll.c.h...ps....F..sl....s.....G++.....h.p.sh.Rptls+hc.+tu.hs...hchh..p..........sph...h....p.clpp.l.u-pWhss.+..................................pEpsF..ohuh..h....c...t....t.......ht..p.....tt.h.sl......hcs.....cG..................................................................cllAFsshh...sht...................ppshol.DlhRt..p..s.....c.s...spGhh-hlhhphhth..tp..p..p..G.................hphh.shuhA.....s.htsh...........s................................t...u..................p+hhthlhph.hpphas.h.pGL+chKpKapPpa.ps+Yhs..................................................................	0	193	362	467
+9757	PF09925	DUF2157		Predicted membrane protein (DUF2157)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4872)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.40	25.40	25.70	25.60	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.11	0.71	-4.59	51	469	2009-01-15 18:05:59	2007-07-30 16:07:22	4	6	466	0	144	421	111	138.90	23	29.45	CHANGED	ltpWhcpGlls.........sssspplhthhs....t..ssttp.....hshhLhhlGulhluhGllhFlAtNWppls+hs+hullhshlhssthsuhhhhh.............................ptpthhupAhlhluull.hGuhluLlGQhYphuuc.h..phhhhWulhslshAhhhppsslhhl	........................................................t.ls..........tthtth...ht...................th.p.............hhh...hlhhlGulhlusullhhlAtNW........pthschh+lullhsl.lhs...shhsuhhh.h................................................................pt..pph....hsps.hhh.hu.uhh.hGuhlAllGQh.YphuuDs.a..phhhhW.slhhLshuhlhp.t.hhh.h...................................................................................	0	41	89	121
+9758	PF09926	DUF2158		Uncharacterized small protein (DUF2158)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5475)	Family	Members of this family of prokaryotic proteins have no known function.	22.00	22.00	22.20	22.30	21.30	21.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.85	0.72	-4.53	18	536	2009-01-15 18:05:59	2007-07-30 16:08:06	4	3	515	0	65	179	7	47.80	68	73.29	CHANGED	FplGDlVpLKoGGPcMTVo.shs........htsushhhCpWFsspu.....cpthFsE-oLt	...FhVSEEVTVKEGGPRMIVT...............GYSSGMVECRWYD...GaGV....KREAFHEsELV.....................	0	6	19	37
+9760	PF09928	DUF2160		Predicted small integral membrane protein (DUF2160)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5477)	Family	The members of this family of hypothetical prokaryotic proteins have no known function. It is thought that they are transmembrane proteins, but their function has not been inferred yet.	25.00	25.00	29.50	29.30	22.50	20.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.27	0.72	-3.89	37	244	2009-01-15 18:05:59	2007-07-30 16:08:49	4	1	231	0	96	238	242	89.80	49	93.67	CHANGED	WMAWThPoAlFFssIushLhsMTlhE.l+pP.ss.R+GhLsIpTTRGDRLFIuLLuuAaIpLuWlGlss...........sslWhuhslSllahhhlhRhs	..............WMAWThPTAlFFhsIuhhLssMTlaE.ltpP..ss.R+GhLsIsTTRGDRLFIuLLuuAaIpLuWlGlss................s.s.l..WhAhslSllahlhlhRhs...........	0	16	43	65
+9761	PF09929	DUF2161		Uncharacterized conserved protein (DUF2161)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5482)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.40	20.40	22.90	38.00	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.52	0.71	-4.18	30	134	2009-09-11 04:54:42	2007-07-30 16:09:03	4	2	129	0	48	143	23	113.40	43	50.24	CHANGED	llsVc.pcG..tVEVhsDPu.PasPRK....sp+++s+LLpEFpRRpGDPNsGGuTR.pslhTAYRQ-ALpsAsaLuttGPs+uucltctssVs.cATpIhpcNHYGWFERVp+GlYsLTstG+suL	...............hlsVp.tsu...tVEVlscPs........sh..t..P..R+.......s.+++sRLlcEapRRpGDPssGGuT.R.tslhTAYRQpALtCAstLs...tG.st+stclppt...ls.pAspILtcNhYGWF-RlpRGlYsLTssGctu.l...........	0	13	27	33
+9762	PF09930	DUF2162		Predicted transporter (DUF2162)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4827)	Family	Members of this family of bacterial proteins are thought to be membrane transporters, but their exact function has not, as yet, been elucidated.	28.40	28.40	28.90	37.90	26.10	28.30	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.59	0.70	-5.21	15	44	2009-01-15 18:05:59	2007-07-30 16:09:15	4	1	38	0	33	43	2	225.80	27	93.79	CHANGED	sssLahhGlLhullIFGlKsGlGhGFuslS.+KtlhhIsuuYhllshll...utlAsphshplhphlhshGhslHsllulhlIhsGlaTl..+cWtspG..KDs...o+pThLAlslPCPsCLuAlhhSshllusslslSshplGhhlGssFhlsl....lloshls+....thshssP.sLGshMlhlGlYFLluulllPuhlpstphphsshth.........sssshhhslllhhsLllsGalhs+tc	...........lh.hGlLhu.lhIFGlKhGLuhG...a..u.sl.o.++thhhIs....hh....Yhhhhhll.......uhlssth.s.....phhphlhphshhlallhulhllhsGlaTl.....+c..Wttps..+ss.................sppohlshhhPCPsChuAlhhShhllushlslSshplGhhl.....ullhhlhl........lhoshlh+.....thphstPh.hLGshMlhlGl.YFLluulllPshhpstph.thsshsh.........shpslhhshl..hhhsLllhGalhp+h.p.....	0	12	27	29
+9763	PF09931	DUF2163		Uncharacterized conserved protein (DUF2163)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5449)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.60	21.60	21.70	21.60	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.78	0.71	-4.47	52	337	2009-01-15 18:05:59	2007-07-30 16:10:04	4	4	307	0	94	298	50	154.50	26	56.38	CHANGED	Mpsh.sssLtsHL.psusTTlscsWtlsRpDGsshGFTDHDpsLsh-GlsacAsoGh........ousslppssGLulDssEsh.....GuLss.....sslsEsDltuGpaDGApVcsaLVNW...s-s.......st+hlhapGslGElpRus..uuFpAELRGLsc.tLspshGR.lappsCsAsL...GDucCtlD	...................................th.thl.ts.t.h.s......shshsahlp..p.t.sGhshuFT-aDpsL.s.h..........s.......u...hh....aps.ss.Gh.........ssuthppssulus...sshclp.....Gshss............stlp..c..tclttGhaDu.Apl...c...ha..hV.s.a......scs..........stphl.lhpGpl.uclpp.ss....s.thph-l+ulsp..tLspstsR.ha.pptCsAsL...GDtpCtls...............................	0	21	61	73
+9764	PF09932	DUF2164		Uncharacterized conserved protein (DUF2164)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5460)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	21.50	21.50	22.40	21.60	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.24	0.72	-4.18	47	470	2009-01-15 18:05:59	2007-07-30 16:10:22	4	1	443	0	102	324	16	74.70	32	88.77	CHANGED	Iclsp-p+pphlspIpcYFpcEh-p-lGshpAchLLDFhscElGPhaYNpultDApthlpc+hpslpp-la....tlE......K.	...............Iclsp-p+pchlsplpcaht--hp.ElGpFpAchLl-FhhcclGPhhYNpultDApphlpc+hpslpp-la.lEp................	0	23	53	79
+9765	PF09933	DUF2165		Predicted small integral membrane protein (DUF2165)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5472)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	20.80	20.80	21.50	21.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.85	0.71	-4.51	25	244	2009-01-15 18:05:59	2007-07-30 16:10:43	4	1	207	0	58	154	29	137.60	37	94.20	CHANGED	h.hlRluKslhlhulAhFusLVuasNlTDYsoNasF.VpHVLsMDTs...FPss..sltaRAIssPhlapsuYhhIIshEslsulLChhGuhpLh+sh.psssssFppAKshAlhGlsluhLlWhsGFhsVGGEWFsMWtScpWN..G.puAFRFhhhlllVLIals.s-	........h.RhuKhlhshslAhasslVshsN.lsDasoNatF.VpHVhsMDoh....a.ss....slhhRAIsoP.......hlpphuYhhIIhhEshsulhhhhGuhthhtsh.t.sstsFppuKhhshhuhshshlhW.hsFhslGuEWFsMW.Sp.WN..G..sAhRhhhhhhhsLlals............	1	18	38	48
+9767	PF09935	DUF2167		Protein of unknown function (DUF2167)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4714)	Family	This domain, found in various hypothetical membrane-anchored prokaryotic proteins, has no known function.	25.00	25.00	27.90	29.80	22.00	20.10	hmmbuild  --amino -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.45	0.70	-5.54	15	227	2009-01-15 18:05:59	2007-07-30 16:11:22	4	3	219	0	39	156	51	235.70	49	77.40	CHANGED	ulp.tsGsIsLstcpAsLsLPsuahaLsssDsp+lL.-taGNPPsssp..LGhlhPss....sspsWhVllpY-ssGYVoD-DAscIDhs-LLpsM+puscEsNcpRccpGhsslcllGWAptPpYDsso++LhWAtcL+spuu......ppolNYslRVLGRcGVlsLNhVAuhspLsplcpphpplLuhscFscGpRYADFssssDKVApYGLAALVuGs....lAuKhGLaAhlusFLtKFhKllllullulhu	................................sA.ssGPocIsLG.DcATLNLPcGFsalPAc-Auha...M..+ph..G....NhsD--h.hhGLVh.c-.......hshalslEYDDSGYVKDDDAKsWDADELhcsL+cGTcEuNK-Rht+Gl-sIEllGWlEKPsYDAssHRLIWSss.lpDhGsst...s-puVNYNTYlLGREGYhSLNLV...TDcuslD.c-h..PhA.c.clLoul+FNsGpRYADFNcSTDKIAEYG....LAALIGGl..............AAKKlGLLAhlGlhL....lKFWKVsAlGVlAlGA...................................	0	6	15	29
+9768	PF09936	Methyltrn_RNA_4	DUF2168;	SAM-dependent RNA methyltransferase	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4752)	Family	This family has a Rossmanoid fold, with a deep trefoil knot in its C-terminal region. It has structural similarity to RNA methyltransferases, and is likely to function as an S-adenosyl-L-methionine (SAM)-dependent RNA 2'-O methyltransferase [1].	20.80	20.80	20.80	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.22	0.71	-4.79	28	174	2012-10-01 22:53:19	2007-07-30 16:11:38	4	2	169	1	76	201	25	181.90	45	76.98	CHANGED	hsslhlALlHYPVhsKctclluTAlTNLDlHDIARouRTYGlppYYlVTPlpsQppLlc+llsaWpcGaGupYNPsRpEALplV+lssoL--sl--lpphpGpcPhllsTuA+.h.tsssloappl+chl..pscpPhLLLFGTGWGLspElh-psD.hlLEPIcGt..ucYNHLSVRuAsAIILDRLhGc	..................................................t.tplYluLVHYPVhNKptcllsTulTNhDlHDIuRsu+TYslptYalVsPlcuQ+cLsp+IlsaWppGhG..upYNPcRp-Ahphlclssol-sslccIcc.tcGp+Phl..l.sTuAR.....t........hsso.....loappl+chl..ps-cPhLlLFGT.G.WGLscElhptsD.alLE..PIpG.t..ucYNHLSVRuAsAIILDRLhG......	0	44	67	75
+9769	PF09937	DUF2169		Uncharacterized protein conserved in bacteria (DUF2169)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5351)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	38.20	32.40	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.78	0.70	-5.33	44	398	2009-09-11 05:29:39	2007-07-30 16:11:59	4	39	234	0	153	377	32	263.10	25	49.67	CHANGED	-.pGpphlslslKuoasls.tshh........sppQtslh.u-pah.G-Puhouhh.hpsDhshhKstsDlllpGpAauPtGcsssplp..VslcVGs.....hpKtlpVhGcRhW....h..ssstsosPpPFpp..hPlsa-pAaGG..........s.....tsh.cNPlGpGa..tpppttt...thslPslEts.sp.lpsss.....tp.t.PsGFGPlshtW.sRt....phAGT.YDcpWhcs...chPhL....PpDaD.RaapsAPsDQphst...h.pGGEtlpLhslps.p...sp.lpapLPtht.hshhh........h.hsss.........hpphphplDTlhl-s-tpplhLlWR	..................................................................h...tt.hhslssthshpl...............st.t.t.lh.ss..a....sts..t.t..uhh.......hDhs..Ksts-hl.l.sGpAau.s.tsp.sspt..hpstlplss.................hp.Kt...lplhGsR.a.........................sshthstsp.Pa.p..hslsaphAaG.G..........................................sh.tNPhGhGhh.t....tt........h......................hPslp.s..pp..hptst......................tt...ssuhGslshtW..Rh.................phh....Go.aDpt.W.hpp.......phPh..h......................PtDhD.+aapsAssDQ.hsth......h..puspphpL..hshpsp...........tt.lthpLPthpshshlh.........tpst........................hpphshphcTlhl.s.....c..p..p...phhlha+............................................	0	56	94	124
+9770	PF09938	DUF2170		Uncharacterized protein conserved in bacteria (DUF2170)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3789)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	19.00	19.00	19.80	27.60	18.90	17.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-4.82	28	545	2009-01-15 18:05:59	2007-07-30 16:12:18	4	1	536	0	65	200	8	131.50	57	94.39	CHANGED	hs.WslpsLtsuLsspsphpstphsh.llp..Gs-ssLplshp-hs-LPlaluloucQ.IlspuhLasss-Vp-..tsthN-tlL+sp.phhPLSohGltth.csc-hYshFGALSssSolsslltEltTLA-Nslcss-shpsahp	.....................M..sWsPhsLAsALpslsE...pph-...ls..NsEuuLIIKMNDYGDL.IslLFTScQ.hlIETaICPVsoIss..ssEFNpFLLRNQ.KhhPLSSVGIopV.pQEEYYllFGALSLpSSLcDIlLEIToLVDNALDlAEITc-YS.p.......	1	12	26	44
+9771	PF09939	DUF2171		Uncharacterized protein conserved in bacteria (DUF2171)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3798)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	25.00	25.00	25.10	26.10	23.70	24.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.20	0.72	-3.97	17	134	2012-10-02 14:14:57	2007-07-30 16:12:29	4	2	117	0	59	143	4	66.70	44	70.39	CHANGED	pI+EHh-VluuDGsHVGTVDHl-G.scIKLTKpDts.........tsGcHHaIPhuWVspV-ss.+V+Lstsu-pshp	...pI+-Hh-Vluu-Gs+VGTVDHl....-.G.spIKLTKsD...............sGpHHhIPhuaVscV-ss.pVhLstsucpsh.p....	0	13	33	48
+9772	PF09940	DUF2172		Domain of unknown function (DUF2172)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4310)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. An aminopeptidase domain is conserved within the family, but its relevance has not been established yet.	19.70	19.70	19.80	19.80	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.26	0.70	-6.09	18	203	2012-10-02 19:46:12	2007-07-30 16:12:41	4	4	195	1	42	243	564	367.60	46	85.76	CHANGED	LplHEVPSGTpVFDWTVPpEWNl+-AaltsssGc+llDFtcsNLHlluYStPVctploLcELpsHLaSLP-pPDhIPYhTSYYpcpWGFCLsapphpsLp-GcYcVhIDSsl.ssGsLoYGEhllPG..-occElLlSoalCHPSMANspLSGssVhshLAchLtspspR.YoYRhlFlPETIGSIsaLSRN.-clcc.lctGhVLoClGDcp.saoahtSRpG....sshhDRlutHVLpcps.psachhsFhs.hGsDERQaCSPGhDLPVsslhRohYGpYPEYHTStDsLchlsPcuLtsuashlpcslplLEsNpsYh.s.sshGEPQLGKRGLYsslusppph.t.pths.........hL.lLshuDGppoLLDIAEphshsFhcltshsctLhcsuLlc	...............................................................................LchHpl.oGTplaDWhVPpEWsl+-AaIhs.sp.Gc+IsDFtcpNL.HllsYS.slctchsL-ELpsHLaol.-.PDhIPYh..T..SY..Yp.cpWGFClsHsphp...tL....c......c......G..c..Yc..V..hIDuch..csGs..LsY.uEall.PG.........poccElLlSsal..CH.....P....S.h........AN...spLSG.s..lshhLA........+hLh.....u...h......cp...R......Y......oYRF..l.h...........h....P....t....T......I...GuI..saLu..+.........ph...-.pL.c.....+.............V+tGhV.LSClG....Dst.......sh...o.....h.h..+.S.++s......s.s....D.+lhhHs..L.pp.p..........p.sa.c...hasFhs....h....G...DERQas....u.PGhNLslsslpRoh.Yu..cY..spY.HTStDsL.s.FIo.cuLts.uhph..htc.h.I...hL.EhN.tsah.N.o.hs..EPpLG+RGLYto.....lus...ps.....ch........h.........hh.hLshsDGppsllDIAp....hhsh.hhphtphh-+ltthGLl...................................................................................................................................................................................	0	15	27	35
+9773	PF09941	DUF2173		Uncharacterized conserved protein (DUF2173)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4831)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function.	24.20	24.20	24.90	26.10	23.60	24.10	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.26	0.72	-4.11	11	47	2009-01-15 18:05:59	2007-07-30 16:12:56	4	1	30	0	31	40	0	106.30	40	93.38	CHANGED	.pLccLMplsGVhAAscFosDGcLh..EacG..plscchAchsAphCuANshhspMpAcuaophoGpsGWpPhpGWslsGs-auVClsGshuVFVcpscssasclhcsLpps	..t.cLc+LMpLpGslAAGcaosDG+Ll..cYpG.....shsc-hA-MlApMsAANshMuphpA-uaothS......Ghc.WsPhhGWAVsuu-YsVClhGNhGVFVchscADFNplF+sLtc.....	0	11	23	27
+9775	PF09943	DUF2175		Uncharacterized protein conserved in archaea (DUF2175)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4847)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	25.50	29.00	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.43	0.72	-3.96	10	32	2009-01-15 18:05:59	2007-07-30 16:13:27	4	1	32	0	18	31	5	97.60	40	92.31	CHANGED	p+WKCslCGcsIhpGpLFTFhSc.GsVHa-ChccctspKhpt-s..plssL.pL--hlpcslVhtccLsplu-sEElKcllcpscKplE+tAAcLT+clpch	..pKW+CslCspsIh.spLFTFhpp.GslHasCLccchhppsph-s...thhL.pL--.L+phllhtpcLppltp.EEsK+hlcphcKshE+pAuhLTphlpc.h.....	0	4	8	13
+9777	PF09945	DUF2177		Predicted membrane protein (DUF2177)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4852)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.10	20.10	20.10	23.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.68	0.71	-4.15	50	240	2009-09-11 01:55:54	2007-07-30 16:14:14	4	1	231	0	82	203	342	125.50	36	93.84	CHANGED	Mpph.llhYluohllFlsLDhlWLuhlucshYcsplGslhtcp.....hRhsPAllFYLlYluGllhFslhPultsushtpul.lhGALlGhhsYuTY-LTNhAsL+sWshphsllDlsWGshlTusuuhhGhhl	............phlhhalsohllFLllDhlWLshhucph...YpptlGsLhtst.....schsP.AllFYllYlsGlshFslhPulpp.........s.sh.st.......sl.lhGALhGllsYuTYDLTNhATL+sWshphsllDlsWGohloulsushuhh..............	3	26	46	61
+9778	PF09946	DUF2178		Predicted membrane protein (DUF2178)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4854)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	22.50	22.50	22.50	23.20	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.38	0.72	-4.32	12	56	2009-01-15 18:05:59	2007-07-30 16:14:43	4	1	44	0	46	58	1	111.00	20	81.38	CHANGED	ppaphllhhlshhhGul......luaAhssGsshlAlhsVhhGlhhhhhl+p+l-s...VlEDERhh+luEKAShhTlplhsl...shALuGshlh....shp..hsthsphuhhlsaushhlllLY	..............................hhhhhllslh..hshl......huausps.....ups...hlu.hhshhhuhhlh....hhh...cp.plcc.......l...l.EDERsh+IsEKAuphTlp...lhhl...shul.tslhhh....hht....t...hh.h.h.h............................................................	0	6	25	39
+9779	PF09947	DUF2180		Uncharacterized protein conserved in archaea (DUF2180)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4855)	Family	This domain, found in various hypothetical archaeal proteins, has no known function. A few of the family members contain a zinc finger domain.	20.90	20.90	20.90	21.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.54	0.72	-4.22	13	46	2012-10-03 10:42:43	2007-07-30 16:15:47	4	1	38	0	34	45	0	67.50	43	89.15	CHANGED	MKCYhCAcEGKDT-AVuICIVCGMGlCh-HllR-ElshWcGGYPaPsc........KlKcsLPRILCh.CasAhpt	...MKCY.CstpGK.Do.-AVAlCIVCGhGlCh-Hsl.+..E-l.shhp.G.uYPhstp.........+hpcsl..PRlLC..ChsAhh.t.......................	0	8	25	28
+9780	PF09948	DUF2182		Predicted metal-binding integral membrane protein (DUF2182)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5486)	Family	This domain, found in various hypothetical bacterial membrane proteins having predicted metal-binding properties, has no known function.	25.90	25.90	27.50	53.40	24.10	25.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.62	0.71	-4.39	51	254	2009-01-15 18:05:59	2007-07-30 16:16:03	4	2	201	0	94	263	221	188.40	34	70.97	CHANGED	hhsMWslMhsAMMLPoss...PhlhtYpclhttt......spstshhshhssGYlhlWhuaullAtslphsLtthuhhsshhs.sts..hluuslLlsAGhYQFoslKptCLspCRsPhsahhpc..WRsG...htuuh+hGl+pGhaClGCCWuLMslhFsuGlMsLhWMuhlolh.......hslEKl....sshGctls....+slGslLlshuhhhl	......hsMWhlMhlAMMLPoss.Phlhtapclhttt......sppshth.shhssGYLssWsuFullAtshphsLpthuhhs.shhs.ss...hluuslL.hlAGhYQaoPlKptCLspCRsPhsa.l..h..pp...a..R.su...htsuhphGl+HGhaClGCCWuLMslhFssG.sM.slhWMuslshh.......hhhEKh....hPt.Gc.h.lu....+slG..ssLlshushl.h.................	0	20	51	70
+9781	PF09949	DUF2183		Uncharacterized conserved protein (DUF2183)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4850)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.50	26.50	26.80	26.50	26.00	26.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.23	0.72	-4.07	76	563	2009-01-15 18:05:59	2007-07-30 16:16:46	4	9	433	0	307	521	33	99.20	37	20.65	CHANGED	shaYVSsSP.WNLashLppFlpppthPtGs.lhL+ca....ssshpphhpsspt...+KhpplcclhppaPphcFlLlGDoGpcD.s-lYsclscpaPspltul..aIRpl	...............................................haYlSsoP.WNlashLppFlpp....psa..PtGs.lhL+-a.........sss.pshhpsusp......+Kpstlcclh.psFPch+alLlGDsGQpD..clYs-.hscpa.Ps+ltAI..hIRp.........................	0	99	187	265
+9782	PF09950	DUF2184		Uncharacterized protein conserved in bacteria (DUF2184)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4834)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.80	26.80	26.90	27.10	26.50	26.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.27	0.70	-5.32	26	275	2012-10-03 06:22:39	2007-07-30 16:17:03	4	3	246	0	39	242	28	236.10	25	74.81	CHANGED	sGtA..phlu.stusDlPtl-lshscppsslthhuhuasaolpELcsApth.GtsLsspKspusppshppplsplsahG.....-sspGhsGLlNp.sulssssssss.......W......tspTs-pllsDlsphlsslhstosh..sthssplLLPsspathLupphhsssssholLcalpcsNh.........hs..tG.sLsIpsltt.LcssGsuGs.......sRhlsYcpssphlphtlPhshphLPs.Q.pslchcVPhht+hGGlplhhPtsltYhDGI	.......................................h...t..phlu.ptuss.lstlslshscptsslthhuhthsaol.ELpt..Apts.Gps.ls..spKhc..uhphthphc.schsahG.......-ssh.s...lpGLlNt.sslssssssts...............W.......sssTs-...cIhss...lsp.hlsssh.tt.osh....sh.........s.Ps....s.LhlPsppa.shLssphhs...s..s...s.s.polLpalppNsh.............t..sLs.Ip.....s.......lh....L.......c......st.G..susp.........cp.h.lsY.........spc.........chlph...l.hshpt....lss..Qhc..s.lh..hsshht+hGuVt.hh.tsh.hhDGl...................................................................................	0	4	23	30
+9783	PF09951	DUF2185		Protein of unknown function (DUF2185)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4859)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.30	26.60	23.60	24.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.93	0.72	-4.19	11	257	2009-01-15 18:05:59	2007-07-30 16:17:12	4	19	221	0	31	197	7	88.00	33	31.24	CHANGED	sIVSNsVh.-+R.hsFha+EssphEsDSGWRhFSG.EoD-YssDP.cNFpIlSlusIhplDsolhtlLppP.ssAaEhs--Gs.F.cltDa	.....CIsosplh...ps.ptlsahaRE.pP..s..t....p..s...DSGWRhhSGsEoD-YhscP....cNhsl....lslsslhph-Psllsl.ls.t.P..Go....saph..scpGt.a..l.........................	0	17	22	27
+9784	PF09952	DUF2186		Uncharacterized protein conserved in bacteria (DUF2186)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4861)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.10	20.10	20.40	22.00	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.77	0.71	-3.94	11	178	2009-01-15 18:05:59	2007-07-30 16:17:31	4	3	169	0	45	154	10	143.50	27	41.90	CHANGED	RLh.ctccLL-pWAtsYPs+Lps+hphhcFsu..st.sWhpphsltshsA......hhuGEsAAscLss.l+PsshslY....stpshsscLlhptRL+c.......sspGs.Vplhcs.....FWs.p..................shtchslssPhllYADLluoGDsRshEsAphIh...-chls	......................................Lh.cscpLL-tWsts..YsstL.ttp..h..phht...h...su.......p.......p..hh....t.h..s..ls..s...t...............thuGEsAus.h.st..hp...Pts.h.hlY....sssshsscLlhpt+h.+.........sscGs...lhlhch......FWps...................ssp.p.sslsPshLlYADLLsos-sRshEsAchl+..-....t.............................................	1	18	30	37
+9785	PF09953	DUF2187		Uncharacterized protein conserved in bacteria (DUF2187)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4873)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	21.60	21.60	22.00	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.74	0.72	-4.24	7	524	2009-01-15 18:05:59	2007-07-30 16:17:44	4	1	440	0	39	139	2	57.60	57	85.89	CHANGED	MphAcVGsIIEFKsGLpGIVEKVNENSVIVDLThMENa+-L-l-p+TVVNHKNYKII	..................MplAcVGsIl......E.F....h.s....G...l..pG+V.EKlN.-NSVIVDlTIM-NFs-...L...D..l...-KTVlNHKpYKIl.......................	0	5	16	26
+9786	PF09954	DUF2188		Uncharacterized protein conserved in bacteria (DUF2188)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4876) & Jackhmmer:B5ZC26	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.02	0.72	-4.05	101	747	2009-01-15 18:05:59	2007-07-30 16:18:01	4	2	643	0	192	487	10	59.90	24	57.15	CHANGED	haVs..P.tpsst.......WtV+tp....Gss+s.sphasTpp-AlptA+phA.cp....p.su-lhIHsp.D.GpIpccpoa	..................pptt........Wtl+st....sspps.otphss+p-AlchApphu.+p.............p.ssplhl+pp.D..spht...............................	1	56	107	147
+9787	PF09955	DUF2189		Predicted integral membrane protein (DUF2189)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5473)	Family	Members of this family are found in various hypothetical prokaryotic proteins, as well as putative cytochrome c oxidases. Their exact function has not, as yet, been established.	22.80	22.80	22.80	22.80	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.81	0.71	-4.20	69	418	2009-01-15 18:05:59	2007-07-30 16:18:23	4	1	318	0	155	393	69	127.20	27	45.87	CHANGED	llhshsuGFhLl.GPh..hAlGLY-lSRRhEp...Gcsssh..tpshts.....hstshsphhh........huhlLhllhlhWhhsAthlaAlhh.s.ss.shss.hsshht.lhhsspGhthlhlGsslGulhAsllauloVl...........ohPllL.D	................................................hlhshssGFhLl.GPh...hAlGL.Y-hS+chEp.......Gptssh..tpshps.....hs.shsphhs..........huhlL.hlhhlhWhhhuthlaAhhh.u...sh.shss....hsshht.shhsspshthlllusllGslhAhlsauloVl...........ohPhhlD..........................	0	36	96	124
+9788	PF09956	DUF2190		Uncharacterized conserved protein (DUF2190)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5471)	Family	This domain, found in various hypothetical prokaryotic proteins, as well as in some putative RecA/RadA recombinases, has no known function.	20.80	20.80	21.50	21.30	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.31	0.72	-4.27	30	380	2009-01-15 18:05:59	2007-07-30 16:18:52	4	1	318	0	62	202	18	105.40	45	95.92	CHANGED	MKNYlQsGcslsls.Ass.uVsSGssVllGs..lhuVAh.sssssGpssphhspGVF.sLPKsuussh.shGstVYWDsospshTs..suouNshl....GhAhtsAussu..sossV+Ls	....................................AKNF.Vp-.GcTlslV..Aus...uIpSG-hV.V.Gs.............lhAVAl.TDIstG.....EsG-...G.....h...sEG.V......F.hLPK...h...p.s..D.Dh..psGppV.........YLKsu..t..lQLss........usu.ssh.l.....GVsWtsAusuu..ppVsVKlN..........................	0	15	35	48
+9789	PF09957	DUF2191		Uncharacterized protein conserved in bacteria (DUF2191)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5450)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.40	23.40	23.60	23.40	23.30	23.20	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-8.03	0.72	-4.15	51	685	2012-10-02 18:44:02	2007-07-30 16:19:12	4	2	332	0	155	436	50	47.60	33	65.80	CHANGED	MRTslslDD...pLlpcAhclsG.lpoK+plVchAL+sLlppcp....p+...th.cL	.........RTsIclDD....cL...l..scA.hchsG..hpoK.+..s..sVchAL+p.llpttt......tc.....p....hh......................	0	43	111	140
+9790	PF09958	DUF2192		Uncharacterized protein conserved in archaea (DUF2192)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4879)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.60	20.60	20.60	22.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.44	0.70	-5.13	12	48	2009-01-15 18:05:59	2007-07-30 16:19:24	4	1	46	0	29	44	0	223.30	36	83.96	CHANGED	hs+plaRcRIcshhsLlpclLpt...thhoRpsllt.LpcsYcccsIcPhRGhu.spslY-KElAolYVVGKYGhGlhs-..t.FDclF.hEpph-EAhcll......lstphpEAhtchss.l..ts.ccspltRhLRllFTtslhGahsEptLlKsl+shp.s.hP-hpcphhsYutFYsAaKlAEsIAtGcIRs+.shcAhKhuhAlclGh..p+slPsDchIAhIAppVapVscphLs+lL	..........................................sKpla+cRIclhs-lhupllcp....psloRpsll-llcpsYcccsIcPhRGhs.ssslY-KELsolYVVGKYGLGLh..-.-...phF-+lF.hEpph--shclI........lsspspEAhcch..ss...t...sc-hlARsLRhsFTpslhuF.sE-chh+sL+slphu.hs-lccsspsau+FYsAaKlAEsIApGtlRs+.shpAhKpAlAlplGh..phshPpscYluhIAccVFpVscclLs+lL............................	0	11	17	22
+9791	PF09959	DUF2193		Uncharacterized protein conserved in archaea (DUF2193)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4883)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	25.00	25.00	403.50	403.00	22.30	17.80	hmmbuild  -o /dev/null HMM SEED	499	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.74	0.70	-6.24	9	32	2009-01-15 18:05:59	2007-07-30 16:19:37	4	1	31	0	23	33	2	497.80	65	99.61	CHANGED	MpELYcKMlDEAMuAQ+ADV-slK+KRGpcFplpDAKPYVDsVpKMcssusQSpuVhsLHhsSVpuHa-lLsuLTcTVRPEDDPFVEHYQTPsILEILh-EDstFpKSl-tFlcuItKuEALIG+EulRRYGGFYGPTCVVDFALlPGSTSNVVNRILppsDIPhcHKQAILAAKSWGMNTSYGIG-hFAptlEtGsThuEAs+cEI-MlQhlYcpPlEAQAcLMDsAGppSFDsRKYMpsY+p+McssV+AAhD-GVHYGNIlTVPAYCVGDlAHHIuQSTFNMCKDDVVMAlIEAsTsVMEoTLpsAlspFKsEYslLoLATGuSAsAsEaILELDGFNAhMlVDLLTKRFHNYV.haPTRGAAAELHNsDFMDMIYRGW+hlDKAcRspsutpt.l.PhVuGasVDLSPIacNEVlMNPQRYAYPACAITVRFSALMRLADYPCLLTSEPVTAThMTNIIALHKEssuuPARsCKsCAsAsLlDaRHpYCQWKEAV	..MpElYcKMlcEAMAAQpADVpsIKcKRGpcFKIcDAKsYVDsVsKMcslssQupuVlcLHhcSVpuHa-lLsuLTcTVRPEDDPFVEHYQTPsILEILY-EDspF+KSl-KFIcsIs+uEALIG+EslRRYGGFYGPTCVVDFALIPGSTSNVVNcIL+psDIPtpHKQAILAuKSWGMNTSYGlG-sFApslEsGtThuEAlccEIchlphIY-pPl-AQA+LMDst..G....HpSFDVRKYMspYKK+McssVpAAh-ssVHYGNIVTVPAYCVGDIAHHIuQSTaNMCKDDVlMulIEAsosVM-sTL+ssl..sp..FKsEY-lLoLATGSoAsAsEYILELDGFNAsMVVDLLTKRFHNYVQLYP.TRGAAAELHNsDFMDMIYRGW+hlDKARRs+sGsts.ltPcVuuacVDLsPIccNEVlMNPQRYAYPACAITVRFSALMRLADYPCLLTSEPVTAThMTNIIALHKEssuuPARsCKsCAoAsLlDFRHpYCQW+EAV................	0	8	18	20
+9792	PF09960	DUF2194		Uncharacterized protein conserved in bacteria (DUF2194)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4878)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.00	26.00	26.70	26.80	24.40	25.90	hmmbuild  -o /dev/null HMM SEED	585	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-13.07	0.70	-6.47	8	111	2009-01-15 18:05:59	2007-07-30 16:19:48	4	3	107	0	24	106	3	535.50	29	88.40	CHANGED	lhllLhh.hlu...........................................................................................................IshhhsKhGlpYshss+p.h..t.........s.sssslspsh-p....plh.................................LaDsNs-supcl.......................c..........pphcphLcYh+hphchls.u...pcshPSl.cY+sllIhhs-lstls-..pslhsalEsGGsllhAsshc+ssthssI...hGlp..p.-hsclcslhlspDlh..lGuscs.thpt.F.cpulslsLsscsplphlossc.pTPllWppchGpGphlhhNhsllpKp.lRGlassuhuhhsssslhPlINutshYlDDFPuPlPuG-tc.lp+-a.shoss-FYpKlWWPDlpKLuEcYsIKYTGlhIpsYpssTsss.shhctpspscalhaGppLL.ssuGElGlHGYNH.PLs.cs.s.hcc..tYh.Wts+EshtcuLcpLp+Flps.LhsshphssYVPPSNllscpGhcsLhcshPpIKoIuSsYhssc.ptsY.QEFplt-..cGhlclPRhTSG.hhsscphhhsshssLs.hGVhsHFlHPDDlLDtDRu.uphuWschhKsLcshlchl+cpaPaLRshTuSEsusulpcYtshcsphphscsulclslpshccpsthhlRts+sp..KlpGGp.....lh+h..susLYl	...........................................................................h..............................................................................................................................hhp..s......t...t.....................tt..th.h..tth..tt.phh...........................................lhcsssp...upph.................................hpphcphhc.h+hthp.hs.s...pt.hsshtsYpslllhhsph.ptlsp..h.pl...hpaVppGGsllh.....utp.pp.ss.h...ssl..........hGlpptt..t.t.p.s.pslhhppshh...Ghsp.h..t...s..t...h.cou......h...p.......l...............sLs......pssp.lhh..ho........scs....hP.llWppshGpG+llhhNs.s.h.hpcp.sRGlhssshuhhssshhhPhlNupshalDDFPuPlPpspsc.lpc-Y.phosp-FYpplWWsDhhclucchsl+YTGhhI..tsYpspsps....p.hp..........t..p.s..h.........pph.hhaGppLl....ppGGElGhHGYNHQPLhhts.phhtth..sYhsWtsppsMttulppLhp..ahpp.hhPphphpsYVPPSNllsppGhpsLtcshPplcsIuShYhsspp....s..a.QEFthsp..c..s..lhphPRhoSG.hhhsc.p.hthhstlshhhlhoHFlHPDDl.........lD.............t-........Ru.tphsWpp.......Lhcshcphhp.lppphP.l+shTtSEhssthppatshphphphp-stlplt..htshhptshhhlRhpps.....plpsGp.....hpcl....ssplY....................................................	0	11	14	20
+9793	PF09961	DUF2195		Uncharacterized protein conserved in bacteria (DUF2195)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4893)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	73.70	73.60	22.40	16.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.52	0.71	-4.32	6	124	2009-01-15 18:05:59	2007-07-30 16:19:56	4	2	121	0	8	50	0	122.80	52	92.21	CHANGED	sllLuusshs.uPhhAsAus.h.l-NsLuAClch+sut.....psucshltl.hslph++ShG-CGChSALlpYpslstpt.....susphsLQcGlhsstpsssR...TLsLAsDssLst-pplslplGCsssc	....l.hhphsuGh.lslhA.sGp.l.IcNsLAtCVDh+st+.....pphsNllhlpsshpL+KshGtCGChSALspYsS.lsp......RtSthhLQpGlhsLtKpss+...oLsLAs-stLV+DtpltlpluCs.P..	0	2	6	8
+9794	PF09962	DUF2196		Uncharacterized conserved protein (DUF2196)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4895)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.20	25.00	24.00	22.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.88	0.72	-4.18	39	362	2009-01-15 18:05:59	2007-07-30 16:20:21	4	3	326	0	139	286	19	60.90	60	66.71	CHANGED	hsGppRssIp.GhpVsI.VLKpDQRoGpLTcGlVp-ILTpSssHPHGIKVRLcsGpVGRVpcI	.................MsGppRusIpsGhcVsI..VLKp..DQRT....G..+....LTcGlVKDILTNSssHPHGIKVRLp..D.G.Q..VGRVQpI......	0	47	101	120
+9795	PF09963	DUF2197		Uncharacterized protein conserved in bacteria (DUF2197)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4896)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.20	22.20	22.60	22.20	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.96	0.72	-4.01	13	385	2009-01-15 18:05:59	2007-07-30 16:20:30	4	1	354	0	37	121	0	53.10	48	86.80	CHANGED	M+VKCllCDpl-pID-cohhAKRLRNRPIHTYMCc-Cc-RIccpTppRhsTGpFph	...hpVpClICDpKshlD-coscuKRL+N.p.PI+TaMCc-CcpRlsp.p.c...utpa................	0	13	22	31
+9796	PF09964	DUF2198		Uncharacterized protein conserved in bacteria (DUF2198)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4897)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	30.20	30.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.41	0.72	-4.22	9	297	2009-01-15 18:05:59	2007-07-30 16:20:41	4	1	297	0	21	75	0	72.70	63	95.13	CHANGED	hphlhALhFPslLVlLFoRVTYN+aVGllLTsALlsAShhKGYTcohalIslDlsSLlAGaLahsphctct+pc	..IWYhSAAFFPClLVVLFSVITRSKWVGTlLTLILIGASlYKtYFHNEWIIFIDVVSLLAGYLIIDQLEFHK+Qc....	0	5	10	17
+9797	PF09965	DUF2199		Uncharacterized protein conserved in bacteria (DUF2199)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4899)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	27.30	29.80	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-11.08	0.71	-4.36	6	159	2009-01-15 18:05:59	2007-07-30 16:20:54	4	2	152	0	24	125	3	142.40	40	83.45	CHANGED	YpCssCGEhHEs.P.SauFcAPssYhplsEEERps.pschuDDLChIp......DGpcaF.IRslLEIPIhGp-EsahWGVWVSlSEsSFc+Yh-oF..spssps.saFGWLsNhlPhY.s.Thu......LcscVHhpsDGpRPhlhLacus.Hs...LshD.ccGI	...................................CtpCst.H......tthP..uhGhpAP......Y...p....lstcE.R.s.....ps..c.....hs.....uDhCll.......DtpchF.IRusL.IPII.sp.....cE...sh.aGVWVSlSccSFsch...ppa...c..c..p..t..p..s..s..sYF.GhLssclPsY.s..Ths......L+s..sVphpssGpRPhlpLc.p.o.s.HP...Lsh-.hpGI.........	0	9	18	21
+9798	PF09966	DUF2200		Uncharacterized protein conserved in bacteria (DUF2200)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4898)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.00	22.00	22.90	23.20	20.20	19.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.39	0.72	-4.20	37	512	2009-01-15 18:05:59	2007-07-30 16:21:09	4	1	506	1	101	279	74	109.20	58	93.45	CHANGED	RIasMoFASVYPhYlsKsEKKGRT+pEVDplIpWLTGYspppLpptlscpssFETFFspAPplNPstsLIpGVICGhRVEEIEDP..LMppIRYLDKLlDELAKGKtMEKILR	........+lYsMpFAuVYshhIsKsERKGRp..p-EVcpllpWLTGY-..ssltt.pLcccVTatsFFtpAPhhsPppthITGhICGVRlEEI-DP..LMQcIRaLDKLlDELAKGKshpplLR............	1	45	82	95
+9799	PF09967	DUF2201		VWA-like domain (DUF2201)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4900)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. However, it is clearly related to the VWA domain.	26.40	26.40	26.40	26.50	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-4.11	16	512	2012-10-10 16:07:06	2007-07-30 16:21:21	4	6	465	0	176	533	365	126.10	24	28.68	CHANGED	lslslDTSGSIssttLspFtuElsuIt++h.tAp.lpllhsDsplpssphhcs..hct.lsclphsGGG.GTDasPll-tAsctcPsssVl..LTD.LpG.PschtP.thPVlWslst.psssss...P.FG+hlp......Ls	......hlslDoSGSh.......s...c..p......l......p........p..........hl..sElh....s....lhpp........h.....pt.....c.....l....pll.p.s.Ds.plpss.thlps...............t....ht.p.....h..p.....l...t..GuG.G.Tca....pssFc...a..s....p.....c....t......p...........p.....s.s..l.....l.....lhhTD..u......ps.......t..htP.....th.....s..ha.lh.t...........t...................P..au......h.........................................	0	70	116	150
+9800	PF09968	DUF2202		Uncharacterized protein domain (DUF2202)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4902)	Domain	This domain, found in various hypothetical archaeal proteins, has no known function.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.98	0.71	-4.57	12	134	2012-10-01 21:25:29	2007-07-30 16:21:30	4	4	106	5	72	171	17	151.70	38	65.03	CHANGED	EtcsLlaMREEEKLARDVYlsLYchWt....lslFhNIup.SEppHhctVphLLc+Ysl.............pDPlhs-phGhFss.clQpLYNpLlpcGSpSh.DALpVGAhIE-LDIhDL.cchhpcosNp...DIphVYpNLhpGScNHhRuFsRslcphGhsYpPpYlSppcappIlpus	..........................EhcsLlaMhEEEKLARD..VYhpLYcpas....l.l.FtNIup.SEppHh.sA.lttL...lc+..Ysl..............s.DP..ss..s..p...t.h.G..hFsssc....lQpLYs..p....Llpp..Gp..p..S..h.h-ALpVGshIE-lDItDL.pchl.ppsssp..............DIphVYpsLhpGS.c.N.HLRAFhpt.L.p.p.h..G..h.sYpPphlsptthptllp..s.........................	0	23	45	65
+9801	PF09969	DUF2203		Uncharacterized conserved protein (DUF2203)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4911)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.80	20.80	21.10	25.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.89	0.71	-3.89	23	128	2009-01-15 18:05:59	2007-07-30 16:21:42	4	1	124	0	57	116	64	118.60	30	87.62	CHANGED	phFolcEApcLLPhlcchhpph....tct+pplcch.......c...............htthcpph..cphtpplcttlcc....lpphGl.lKsl-.GLVDFPuhhss.c.laLCWKhGEs-ltaWHth--GFtGR+sIp	................................+hFTlcEApplLPhlcthlppl....tphppclpph.t.th...tt.tt.....................h.thctch..pphttplcphlpc....lpphGlhlKs..lc.GLlDFPuhhss..c.laLCW+hGEscltaaHth-pGFsGR+Pl...........	0	30	41	52
+9802	PF09970	DUF2204		Nucleotidyl transferase of unknown function (DUF2204)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4914)	Domain	This domain, found in various hypothetical archaeal proteins, has no known function. However, this family was identified as belonging to the nucleotidyltransferase superfamily [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.78	0.71	-4.81	15	161	2012-10-02 22:47:23	2007-07-30 16:21:59	4	2	147	0	66	166	23	151.70	25	59.21	CHANGED	thpsLttlhppLp-+Gl..caVlIGusVlsLuhsp+hsssDVDLFlhshSsll-p-hac-lAcEpsW-hGposhGTsthlshls.uEplpVDh.aENIhDlalPtElLscucclsIsGlcl+sIslE-hlVLKA+tupcEsp-hlcclu...................chlh-..tplplshchl+chlphaPE.-scsIhcRL+p	..................t..pshttlhtpLp..cp..Gl......phhllGGs.shh.l.s......a...sp.c...hs.TcDlDh.....hh..t..s.s..us..h.....l.-t.....l...ccl.A.p..chuW...s..h...shh..s....t...s.....s.....t.hl......h......hs.t-sh..l......h...l.t......s..l.h...hs..t.phl.thp.....ht.h..t...uhc....shEDhh.lhhsphthpps....t...hc.lh....................hh.t.................................s....................................................	0	26	44	54
+9803	PF09971	DUF2206		Predicted membrane protein (DUF2206)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4906)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	33.10	33.10	35.60	35.10	21.20	32.20	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.50	0.70	-5.64	9	29	2009-01-15 18:05:59	2007-07-30 16:22:19	4	3	23	0	23	30	1	355.10	19	51.06	CHANGED	tp+tlLhllFhhullhSHYGsAYlhhhhlhhusLhhhlhthh..................p.ppt+hshpLlhlahllhhhW...YshlusuuhFpolssIhtplh......pol...hpp.LsPpsopGhtll.ss.sshhttLhKllplhs.hhIslGhltslhchhtpppp......lpYluhuhhhhhlLlAulhlPaFu.shNssRLaplohlhlAPahlIGh.shhchIsphhp+hh......sh+s.h....thh.ohFlllhhLhs.oGal.plhpspPhShulspts..............cshh.sp-VhuuKWluphpsps..lplhs-hhsshhhhh...............sYuslspphlssspph..................pssYlaLshhNlhpphhhlp.......hh.tthhhhN...hssshphltppNcIYDNtGStIYh	.....................h.p+tlLhllFhhullhSHYuhuYlhhhhlhhshlhhhlht.h.h.........................p.pp.phshshlhlahshhhsW...Yhhlusushhts...lh...plhsp.hh........psl...h.p.hs.psspG...htlh....ht..shhthlhhhlphhh...hhlhlGhhthlhphhhtc.p...................hpY.lhhuhh.hllLlsslh..lPaa.u.shsssRLaplohlhLAPahllGhhthhphl.s+hhpthh..........t..h..............................phh.slalslhhLhs.oGhl.t.lhp.s.sho.hulspss...............tshh.s.spEltuspWlsp.psps............lhsshhph.hh.h....................a..ush...sht.htttpt..p................psuYlalsphNlppthhh.........hhstthhhhp....hsh.phlpspspIYsNusSplY......................................................................................	0	4	12	19
+9804	PF09972	DUF2207		Predicted membrane protein (DUF2207)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4907)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.00	23.00	23.00	23.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.79	0.70	-5.92	46	1234	2009-01-15 18:05:59	2007-07-30 16:22:39	4	3	970	0	247	980	138	434.70	18	83.34	CHANGED	sapIpphpsplplppcGshplpEplsYshcss..hcGlahshshsst...t.......hshpthslppss.......tssshplppssss..............phpltlasss.st.....sphphphpYplpssltha..pDh.uE..LpaplhGssWshslsplpsslphP......pshps..hchasasGshsspsp........tppsplthpsss.l.sssptlElchhh.Pp.....hsssstp.hptphhpph.t.tttht.p................tphhthhhslhhhlhhhh.hh.hhhah+hs+csphth.....................shhpa-hPtshsPshl.shlhptshs....................pc..ultAs.llcLhs+thlplpp................ccshhlplssps..........thsshEptllchlhspt....sspplshtpl...........................t.tpphppthppappslpcph..pptthhtthhhhpstt..............................hhhhshlhhlhuhlhh......................hh.....hhhthhhhhshlhhlhshlhhhh..........................tthhst..hotcGtphhtchcuF+paL..sDh.splphtsst..sltlW-chLsYAsALGlucc...Vt+phc	...........................................................................................tIpthpsphhlpt.-....ss....hphppplhaphppp.........hpG..hhslshhh.h.......s............sh.....htstpss.......................................hs.s.phpt.ptsh....................................................hhl.t.h..p......h..............s.h..phplpaplpshhhhh..............tDh...st................L.Wp.h...sp..s.....tl.tp.hphplphs.............ts...........ph.h.a..G..ttphp...............tp..t..t.....shp.hphps..h...tpt.....hplhhha..sp....................hsssts..t........h...t..p.h..h.............................................tthhhh.hh..s..hhh.h.l.s.hhh.............hh..h.h+p..s...p........h.......................................................................h.h.....ht.P...p..h..p..Phhh..t...h...l..h...p.ht.hp.......................pp....hht.As.llslhs+t.ltl.pt..............................................................tpthhl.ph.ptt...............h...hE....p.hlphhhttt...........p..hsthph...................................................................p.h.pphhpph..ppt.h..htph...p...................ht..t.................................................................h.hh.shh.hhlshhhh...............................................................hh..h.hh...h.....hh.h......h.hhh.l......h.hhhhh...............................................................h..h.sh....hs.ptGtphhh.hpuhpphL......p-h..sph.p.p.ttht...............shh.l.app..hLsaAhhhGhucc...h.p.h..............................................................................................	0	89	175	205
+9805	PF09973	DUF2208		Predicted membrane protein (DUF2208)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4920)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	23.60	23.60	23.60	84.10	23.20	23.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.38	0.70	-5.12	13	43	2009-01-15 18:05:59	2007-07-30 16:22:49	4	2	43	0	27	35	1	234.40	30	94.20	CHANGED	h+plLIS.l.lllaShVLohaPpaah.saILYFllahuIohshshRSh+..pshtshpEIusu+sLhE..EKcuscLhpKDcELhp.Ehpphs+uuhhshlhhhlalllhhllashl...hp....sthssslssths+FLsalshFEhhalluhh..lh+hlh.+.th.sshl..spsaKVoEKGIlsccphG...lthPhc...sschplNc-RKaVEl+.sspt.......plRLYs+-lc+L.slLpRl.KtLct	......................+hlLlStl.hllFShVLu...aa.PpY...a...h...haILYhllahuIohhhshRSt....+phpshtElspu+sLaE..EKcsscllpKDcEhhp.EhpchhKtshh.shhh.hhlhhI...lhhllasal..........................hthssshs.shhh+....FlsallhFphhaulshh...ht+h........lh..+h..pt...hshh..sp.uaKlpEKGllhscphu......lhhP.c...ssplphNc-+KaVEl+sssph.....sh+lRLYspDlc+lh-llp+l.+.lt.h.........	0	10	15	20
+9806	PF09974	DUF2209		Uncharacterized protein conserved in archaea (DUF2209)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4921)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	26.80	26.80	27.00	83.30	26.50	26.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.48	0.71	-4.05	4	22	2009-01-15 18:05:59	2007-07-30 16:23:06	4	1	22	0	19	23	0	123.00	38	95.52	CHANGED	lAVDISGRH+.cDGaY.hVsAuVulEVsAs+I.pVcpVslhsVhp+-s.sLhDIVc.lccslsplu..F-hhIVsE+G-haNpPcWlspuhhupshKYtEohuEhcAIEhAH+lShSsR+LLhcELclp	...lAlDISGRHc.pstah.hVsAuVtspluus+lc+Vcplclh.httccs.slpDllphlc-slspls..h-h.IVsE+G-FaN.PchhVpuhhs+cFKYsEoluERcAIplAHHlShSsR+LLhct.........	0	3	11	15
+9808	PF09976	TPR_21	DUF2133;	Tetratricopeptide repeat	Anantharaman V, Finn RD, Sammut SJ	anon	Manual	Family	TPR repeat	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.85	0.71	-4.25	350	1664	2012-10-11 20:01:01	2007-07-30 16:23:50	4	81	1626	0	351	1305	476	141.70	30	54.91	CHANGED	pspQssptpt..AShhYpplh.pu.h.............s...sscssp...............l.....st............u..schtscassT.YAshAuLhhAKttV-ss-hstApspLph.sls.ps.pDs.sLp.slAplRLA+l.lpppphDs...ALptL....ss....stspua.suh.hs-l+GDlLlu.pGcpppA+sAYptAl	...............................................................................................................t.phppspp.AShtYpph.h.puh..................s.tscs.sp............................l...ss...........spcht..s.c.tt.s.o.....Y.u.s..hA..uLp.l...Apth............l..-p.s.....-............hc............p.A......tspLpp...u.hs....ss...p....Dc....s.L..p......s.....l..h...pL....R..L....A.c..l...l.p.......p...p......h..D..s.......A....L..pp.L.....cs...........l.p....s....p...u...a......s....u.h....s..t..-....l...+.G-hhhu...pGcppsA+sAaptu.................................................	0	100	205	279
+9809	PF09977	Tad_C	DUF2134;	Putative Tad-like Flp pilus-assembly	COGs, Finn RD, Sammut SJ	anon	COGs (COG4655)	Family	This domain, found in various hypothetical prokaryotic proteins, is likely to be involved in Flp lius biogenesis.	21.70	21.70	22.00	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.36	0.72	-2.97	75	253	2012-10-01 21:13:59	2007-07-30 16:25:29	4	5	204	0	106	358	18	100.40	25	18.09	CHANGED	AuAtphsssss..........ss.ssAt...pssspsuh..........................ssst....shslpsGhass.....t.sstshhssss...................sssAVpVsssps.......ls.hhFsshhuh........sshs.lsApAsA	......................................................tuAtphsssss.............ts.ssAp.sss..tpNGh............................ssus............shsltsGpass........sssssppFs.s.uus.................................shNAVpVsssps.............VP..haFsu.h..........sshs..luAousA..............	0	30	60	80
+9811	PF09979	DUF2213		Uncharacterized protein conserved in bacteria (DUF2213)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3566)	Family	Members of this family of bacterial proteins comprise various hypothetical and phage-related proteins. The exact function of these proteins has not, as yet, been determined.	20.90	20.90	20.90	21.00	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.96	0.71	-4.59	32	362	2009-09-11 16:51:15	2007-07-30 16:29:40	4	5	302	0	52	327	29	157.90	31	42.39	CHANGED	ssRphss-GhLlscss.luRsGhphYsucElst.ts......pthlpVhRsPEpVFps-olASF-GhPlTlpHPc......c.VsscNW+slulGtlpNsRR....cu-hllADLllpDtsAIptI.-sG...hcElSsGYcs-a-.ss.......shcucQhsIpGNHlAl.VscGRAGspssl.u.............Dcs	...........................................t-GhLhsps.s..lu+s.G.h..Yhut-lsh.............t..hhl.hRsP-plFpspslsSapuhPlThtHP........thls..scNh.+.p..h.slGpltsstc.......pu.shlhuslhl.......hDps.............uIptI..psG....hcElSsGYpschp....ss.s....................shcu....hQhsI.t.s.NHlAl.V.scG..RuGspstl.tD...............	0	8	33	43
+9812	PF09980	DUF2214		Predicted membrane protein (DUF2214)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3556)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	26.30	26.10	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.91	0.71	-4.46	26	200	2009-01-15 18:05:59	2007-07-30 16:29:53	4	1	198	0	85	192	118	148.80	35	94.81	CHANGED	hlssAllAalHaLuhhhsFuulssEphhLRss.hs..tspstplllsDhlYGluALslLlTGlhRlh.aauKGu-FYhpNPlFahKlsLalllulLSlhPTlsaIpWthslpcspsP..s.shsp+lthllplEhhhhslIPLhAshMARGlGh	....hhpAllAalHaLuhhhhhuslssEt.hhL...Rhs....hs......hsphpplhhhDtlYGluAlsl.LsTGlhRlh.hasK...GssaYlpsPlFHhKluLFlll...uLLSlhPTlshl+W+tsh..+p.....sthP....s...........ucspphtthlphphhLlhlIPLhAshMARGlG................................	0	14	38	65
+9813	PF09981	DUF2218		Uncharacterized protein conserved in bacteria (DUF2218)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3553)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	24.30	24.30	24.30	24.70	22.70	24.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.77	0.72	-3.80	39	357	2009-01-15 18:05:59	2007-07-30 16:30:16	4	8	331	1	97	244	10	88.60	33	72.22	CHANGED	SpuplsTspAoRYLppLCKHauHKhtVpaDsppGclshP....hGpspLpA..sscsLslplpusstpsLsplcpVlscHLpRFAhREs.lplsWp	..............pApl.TscusRYlppLC+Ha.u...HKhs.............sp....a..st..p..p..G.p..lphs..........su.s.spLss..csppLshslpu..spp.slsphcsVlssHlsRFAtREp.lslsWp...................	0	31	62	75
+9814	PF09982	DUF2219		Uncharacterized protein conserved in bacteria (DUF2219)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3528)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	19.00	19.00	22.30	20.50	18.10	16.70	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.86	0.70	-5.59	67	618	2009-01-15 18:05:59	2007-07-30 16:30:29	4	2	571	2	122	391	160	281.60	29	87.86	CHANGED	hth-NDh.hh..u...sDp.tYTsGlplsastss...........thttthsphh...............t..thshpluQphaTPs..ch.....phpss.ssDRPYAGhLhhshshhthpsspt.......phshslGhl.GPsuhucpsQphhHp.llG.......sscsp..GW-pQlcN-hshplshctphphht............shth-ltshspsslG........NlhohsssGsthRhG...pLsssaGsstlp.ss.....ttthh.st..............shuhahasuscsphlspslh.l-Gssa........ppst..sl...shpthhscsphGlshth....t.shplsau....hshtopEFcsppc....hppaGolsluhta	............................................................................................Dp.sYTsGlhLuaopshh................................................shsphuh.pluQchaoPS..sh.........cp..spshhs...DRsau..uaL+sslp..h.u..hssshh...................chshslGsl.GP.sAhupcsQphsHc..lhG.......u-.c.p...uWssQlcN..chshslphhhphp.sh...........shhG..sshslhPpsssshG........NhhphluhGstlphG..pshssc.Ghuhls..st...........h.h.httpp.............shtahlFuGh-tRhlsps....hT..LpGpoh................psph......sV.....slpthVsphplGsshta...........s.shuholu....hsthTsEF+ssc-.......asahshslshhF...........................................	0	45	84	110
+9815	PF09983	DUF2220		Uncharacterized protein conserved in bacteria C-term(DUF2220)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4924)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the C-terminus.	20.50	20.50	20.50	20.80	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.23	0.71	-5.12	31	376	2012-10-01 21:47:57	2007-07-30 16:30:42	4	4	352	0	131	417	28	166.90	19	45.82	CHANGED	GL.......ppcsshlRhRhL-sshsh....sshs-lslshpphupl..plssppllIlENctsaLshP.shs....sulllaGuGauhsplss..hs........WLppp.plhYWGDIDTaGFtILspLRphh.PpscSlLMDppTl.pa.psthstE..sp.pttp....Lst.LossEtslYcpLhpsthtsplRLEQE+IshphlhptL	................................................................................................h....tthtth...th.s.s.pplll.lENpss...a...hshs...phs....................ssl..sla.G....u....G....h.sh.p..t.h.t.p....ht.................................hlps...p...plh..YWGDlDstGh....tI.....hppl+phh....s..........t..........h..p...s....h...h.Ms...tt..h....th....p..hs.p.....st..h.t...........h.t...Lp....t-.hth..hp...tl...ht..............thc.lEQEhl.........h......................................................................	1	53	95	118
+9816	PF09984	DUF2222		Uncharacterized signal transduction histidine kinase domain (DUF2222)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4999)	Family	Members of this family of domains are found in various BarA-like signal transduction histidine kinases, which are involved in the regulation of carbon metabolism via the csrA/csrB regulatory system. The role of this domain has not, as yet, been established.	20.50	20.50	20.60	20.50	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.56	0.71	-4.76	27	713	2009-01-15 18:05:59	2007-07-30 16:30:59	4	8	701	0	82	352	6	146.60	63	16.35	CHANGED	hsRYp-L-cpLlspGsoIIEPLAIASEhGhppcsREsl++LIohsHR+pSslV+SIAlFDssNcLFVTSNaHpsFctLphscshshPphhplphpssolILRoPIluEu...ph....sss.stssssphLGYIAlELshsslpLpQYp-lh	....VHRYNDLQRQLEDAGASIIEPLAVSoEYGMsLQNRESI.GQLISVLHRRHSDIVRAISVYD-.s.NRLFVT..SNFHLDP.Sp..MQ..Lsss........sPFP......RpL.o....VsRcGDl...MILRTPIISES.......................YSP......DESssuDAKsopNMLGYIALELDLKSVRLQQYKEIF..............................	1	11	26	54
+9817	PF09985	DUF2223		Domain of unknown function (DUF2223)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4945)	Family	Members of this family are found in various prokaryotic membrane-anchored proteins predicted to be involved in the regulation of amylopullulanase.	18.60	18.60	19.80	22.60	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.51	0.70	-5.03	16	159	2009-01-15 18:05:59	2007-07-30 16:31:13	4	21	101	2	90	164	135	215.70	27	30.19	CHANGED	hlhphsDPhGDDpGsGsYsYPTsssF.tP..GhFDLhphplh-sussahFphphscl.sNPWsGPpGFShQhlplYlspppGupsssl......sGsNVph..ppsWDhslhls.GW.s..............ushlhsssGsth.....ssshpltssPs.spsIlsplsKphL.t.s.s..phthhllluu.DGYGPDp.hRP.Vu...spus......pWphGGus.......sst..ssssPhVlDlLlPpu..tsQtphLosa..tssphAll...hslsl	...............................h.lhphpDP.GDDpG.s.G.sYsYPssssFp....GhhDLhphplhpt..s....sshhhphphpcl.sNPWs..uP..............sGFShphlplYlc...h...s.p...u.u.ssshht............Ghsssh....ptsWchslhls..G....W.t...............................tshlh.ss.Gsth..............psshpl...tss.s...tssIhsplspphl.t.st......s........sht...hhVhssu.D...Ga...ussp.....hRs.ls...........spss...............tWphGGus.................tstPhlhDhLssps.........tQ...Lt....................h...........................................	1	35	48	69
+9818	PF09986	DUF2225		Uncharacterized protein conserved in bacteria (DUF2225)	COGs, Finn RD, Sammut SJ	anon	COGs (COG1655)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.47	0.70	-4.88	23	252	2012-10-11 20:01:01	2007-07-30 16:31:21	4	3	242	0	98	280	16	223.70	28	87.25	CHANGED	LYcKclpCPVCspcFpscpV+ouuhRlh........++DsDhph+Yps..lNPhaY-VhVCspCGYAAhcpcFs.plsstpp-hlppplss+aps+.......sast..RslspAlpsYKLALls.hplhcs+.S...ppAhssL+lAWlYRhtpc................cppEhhaLppALctaccAYpsEshshp.shscho...............lhYLluELsRRhGspc............-AlpWau+llssssssp....plh-hAR-tacll	...............................................hccplpCPlCsppFpppcl+outh+lh........cc-pDhpscY.ps.....lsPhhYsVhVCPpCGaAuhppc....Fs...p.l...s...stp...t...chlppp.lsp+.h.p.p............sast...RslppAlpsYtL.Al.ls.hph.hp...t.phs...phAhhsL+lAWlaR.hpc.................pppEphahppAhchYpcuhpp-.p.h..s.p..shsphp.....................................................................................lhY..L.lGpLph+hGshc............-Ahpahu+llsptpssp....hlhchAR-.ap....................................	0	51	80	88
+9819	PF09987	DUF2226		Uncharacterized protein conserved in archaea (DUF2226)	COGs, Finn RD, Sammut SJ	anon	COGs (COG1667)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.50	20.50	20.60	20.60	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-12.01	0.70	-5.29	4	41	2009-09-10 17:02:35	2007-07-30 16:31:33	4	5	23	0	31	41	5	233.70	16	84.24	CHANGED	MhhP+s..pVVEschh.....GshcEIhc.luohs...GhlcIos+cG-tLh-uallVpsGKlVushlpclcotEchsuEEAlccLh.......uhpssVlDVYchsc-clphhhchps.....................psls..h.phcl-h.ht.................................................Es..t...s.pth-hsEEhlc-P-..........................................................pREElLKKhGIK.Ps.Ep.lEsILc-hhc.............sshEEhKppl.pph..plh+hpGhs-VhVh.csK.tEt..........sscpllthl++c.................slcEh.ochhR	...............................................................................................................................................................................................................uhl.h....t.....shhhh.tt..lh..................t.h.th..............hl-laphp.p.hphh..........................................................................................................................................................................................ps..t....t.pt.p.h.pphhp..c.p.t........................................................................lsR-cLhKphsl+..s.-p.l-pllcphht...................th...h.pp....h....t.....................................................................................................................................................................	0	9	13	23
+9820	PF09988	DUF2227		Uncharacterized metal-binding protein (DUF2227)	COGs, Finn RD, Sammut SJ	anon	COGs (COG2389)	Domain	Members of this family of hypothetical bacterial proteins possess metal binding properties; however, their exact function has not, as yet, been determined.	25.00	25.00	27.90	27.90	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.28	0.71	-4.62	28	198	2012-10-01 21:01:47	2007-07-30 16:31:49	4	1	192	0	62	150	38	162.70	39	96.84	CHANGED	PSGRsHDRlTl..h.ulPhshlhshh........lsts..huLhs.uuuaLhuGLhhSPDLDlp.S..cthpRWGhLRalWhPYpcll.HRShhSHG.llGohlRLhYLtshshslshllshhh..h.hhshsh.s.h.....thlhphhppp.p.llshllGLEhuuhhHhluDhsssshchh................................+tR+	.................PSGRTHs+IsLh...uLPslhhhha............huhos....hLl......s.uhuaLhGshhLoPDLDha..S.....psap+WGhLRhhWhPYp+lhsHRShhoHshllGsllRlhYhhllhsshhhllshlh..t..............................splhphhpp..ap.hpllshlhGlhluuhLHlIuDtlsoptK+hh..........+...++c......................................	0	16	42	57
+9821	PF09989	DUF2229		CoA enzyme activase uncharacterised domain (DUF2229)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3581)	Family	Members of this family include various bacterial hypothetical proteins, as well as CoA enzyme activases. The exact function of this domain has not, as yet, been defined.	29.40	29.40	29.80	29.40	28.90	29.30	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.43	0.70	-4.88	84	1010	2009-01-15 18:05:59	2007-07-30 16:32:13	4	8	744	0	247	884	34	205.20	36	18.45	CHANGED	plGIPRsLshYc.aPhWt.TFFscLG..ac...VllSstos+clhchGhcshsuEs.CaPsKlhHGHltsLl.c.....Ktl-hIFhPplst.pp.c........tpasCPhltuhP-hl+ssh.........ptshphlsPhlshps......cthtcphhc.h..............hp...l..spc...............-lppAhcpAhcp.cpacp.p...lcppucchlthhptptpp...................sIlLhGRPYpl.Ds.lNhGIschlsp.hGhsVlTtDsl	..........lGIPRsLNhY.EsYPaWt.ThFspL..G..ac...VllSscSo+pla-p.GlcolsS-s.CaPAKlsHGHltsLl..c.......+.slchIFh.....Pslsap....pp...c.........p...ss.spaNCPlVtuYP-sI+sNh........................ptslphhsPalshssp.....ctlhcplhc.h........................hp.h.s.l..stp....................................-hppAlptuh..pc..pta+p.c......lpp.tG..ccslthhpp.pstt............................................uIVLuGRPYHl.DPcINHGIschlss.hGhsVLTEDul.............	0	136	211	231
+9822	PF09990	DUF2231		Predicted membrane protein (DUF2231)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4244)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.00	22.00	22.00	22.10	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.39	0.72	-3.68	51	367	2009-01-15 18:05:59	2007-07-30 16:32:28	4	6	261	0	187	377	94	102.30	23	55.45	CHANGED	ah-luaWslhsuslhshhAslhGhhEhhLs.shh...........tspsshhhHslsulsllulhss........palhRhcssp..pl.hhhLsluhlhssllslpuaLGupLsacaGlt	.......................................................h.psuhW.lhsuhlsuhhAslsGhh.-hhhs....tt......................psppshhhHslhslshhslhss.....................phhhRtp...sst.....tl......h..........h..hL.hlu.hls..hs.llslsuaLGupLsapaGlt.........	0	46	119	163
+9823	PF09991	DUF2232		Predicted membrane protein (DUF2232)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4241)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	24.90	24.90	25.00	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.72	0.70	-5.42	46	942	2012-10-03 02:46:00	2007-07-30 16:32:53	4	5	917	0	226	724	132	260.60	20	81.98	CHANGED	ulhsllhl..lsha.lPlluhlhshhhPlPhllhhh+puhphulh..sllssh.llhhlhss.hhu..lhhhlhhulhGlllGhhl+cppshtps.....lhhushshlluhllhahlhhhhhs....ls...hhsthhphhcpshppshphhpph.Gh.....s.....tphpchhpph.hphlthllPuhlllsuhlhuhlshllst.ll..+Rhphp.h.thssFppaphPppllWhhllsllhhhhhpt.sh....phlhhNlhhllshlhhlQGlullhaah+p+.phspsltl...lhhllsllhs..lhhlltlLGllDl	..............................................................h..hhlhhh..lshh.lP.h.lu...h..l...hthhhslPhhllhh+.t.........t.......p...hulh....uhlssh.....llssl..l.u.....s.s..h.s..........lhhh.l..hhhl.hul....llG..h..h..h.....+...c.....p.pshtph........................lhhs....s.ls..h.h.l.hh...ll.hh.hl.ht.h.hht...........ls......hs.....h.h.p.hp..ps.hpp..s..h..p.h.httt................................tt.pp.hhpph....hp.hth..hhPuhlllhs....hhhshlshhls.h...ll.....p+h.t.h.....s...h.s..h.s......h...t.hph.s.....t.....h.lhhh....h..l....slh...hh.h..h....h.t.........s....................lh...h.N.h.hl.hshhhh.lpG.luhltah..hpt+...thsthh.hh...lh..h..lhh.hhhs....hh.llhllGlhDh......................................................................	0	85	164	200
+9824	PF09992	DUF2233		Predicted periplasmic protein (DUF2233)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3698)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.10	25.10	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.76	0.71	-4.24	288	1904	2009-01-15 18:05:59	2007-07-30 16:34:37	4	62	1410	1	489	1560	149	177.80	21	44.80	CHANGED	ppslhulN......u.....s...h....hs.ptt...................s.G.hhlp.......sG..phht...............sttttshhshp.........tsuthhh..............shpphth........tshpps.l..t.G...........P..hLl.p............sGp.......hh............t.sssst........................tsRoAlGhs.....pcG..pllhls....l-G.....t......tGh.olt-hup.lh...p......h.Gsh.s.....AlNLDGGuSoshh......................hth..h...spP....ssst.................Rslssslhlh	................................................................................................................................t..h.huhN..uu...h......ap.p.t..............................shG..hhlp............sG...phlt..................ttspststhhlp............................sGhhhl.................s.....h....................................................................pshp.u.l....suG...........PhLl.p......................................sGp.........ls..............p..tss............................................sppsRoulGhs..........ccG....pllhll...s-s........................uh.shh-hAp.hhps.......L..G.s...s.............AltLDGGuSoshhh..........................t..h.........s..............................R.l.shhh..t........................................	0	212	355	421
+9826	PF09994	DUF2235		Uncharacterized alpha/beta hydrolase domain (DUF2235)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3673)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function.	21.10	21.10	21.80	21.70	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.00	0.70	-5.03	90	1245	2012-10-03 11:45:05	2007-07-30 16:35:17	4	29	586	0	602	1402	86	226.40	21	51.26	CHANGED	+...pl.l.lChDGTs.....Nshpsstp.............................oNVh+la.chl..........spss............pQhsa...............YpsGlGT...............................tpthpphhssAh...Gtuhspplh....pA........YpF.........LhcpY....psGDc...Ia.....lFGFSRGAasAR........sLA.shl..sphGL.........lp.......................hhhhsacthtp..................at.ttht.t.pt...................phhtthppphs........................p.ssplcFlGlaDTVsul........................................stahhp...............th.....ssth...........sst.................VcpspHAlulDEpRttFp.s....Lhp.......................................................................................................................................sssttsp.......ppVWFsG..sHuDl...........GG...Gas..............ttpttLSc.lsLsWMlpcA	..............................................................................h.lhhDGT........pp.ttt....................................................oNlhclh.phh...................tt........................................hh.h............Y............GlGo.............................................t....h.t.hhs.sh.......u..........s...htt...pl....tu.........................................................hth..................lhp.h..............ssp.......lh............................hhGF...SRGAhhsR..........hs..thl......................................................................................................................................................................................................................................................................................hplphl.GlaDTVsul...............................................................................................h..t..................h.....h.h........................s..................sphshHhlu..hc..EpR...ht.F..s..ht...........................................................................................................................................................................h.phhasG..sHu...Dl..................GGGh............................................hs...hsh...hh.......................................................................................................................................................................................	0	164	331	481
+9827	PF09995	DUF2236		Uncharacterized protein conserved in bacteria (DUF2236)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3662)	Family	This domain, found in various hypothetical bacterial proteins, has no known function. This family contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.	21.50	21.50	21.60	21.50	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.35	0.70	-5.08	128	1684	2009-09-11 16:50:31	2007-07-30 16:35:46	4	16	655	0	676	1614	392	240.60	18	70.56	CHANGED	hshcsatchssh...hhsussullhphhpPtlstulhcp................usap..............p..csht........RltcTspalhsss...................au.sspputthttcVRthHtpV+us.......hss............................G....tsYsAhssplhhWstsshshshl.tuhpt....h.sh.lsss-t-phapphthluphlGl..c.h..Ppotsphtphhpphh.pt.lpsstps+pl.sphlht................hsss..hhh.......t.hhthhh........hhshshLsstspc.hlGlshsshtpth....hhhhhht........tshthl.ttl	...............................................................................................h.......p.......hhhshtulhh..p..h.hhPtlstulhcp....................upht.......................p..cs...hp.........RhtcTstalhsss................................as..ssp.....utt..httpV+.thH.tplcus...p..........................................................G........h..a.ps.s.stlhhastsshhhshl...pshcp.......h..s....t..............l.o.t.t-.t-phap.p..h.thhuph.h.............Gl................c..h.............Ptoh..........t..........pht..........p..........ahcp......h..........h................p.....lp...s..sttscpl..hphlht.................hsh....h..................t.ht..thhh..............hhshshl.s..shh..pc...hhs.l....hsshtpth.......hhh.hht...............hh........h............................................................................................................	0	164	398	587
+9828	PF09996	DUF2237		Uncharacterized protein conserved in bacteria (DUF2237)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3651)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.40	25.40	22.90	19.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.54	0.71	-4.61	79	426	2009-01-15 18:05:59	2007-07-30 16:36:10	4	2	408	3	165	373	1622	108.90	51	88.89	CHANGED	shNVLGpsLpsCussPhTGFaRDGtCpTsspDhGsHoVCAhhTsEFLpaS+tpGNDLSTPtPcasFPGLKPGD+WCLCAsRWhcAh-sGhAP.VhLcATHppAL-lVsL-sL+paAh	..................................t.hNVLGtsLps..Cu...p..c...P.....h.....TGFaRDGhCpTsspDhGpHoVCAlhT...sEFLpao+u.h.GN.DLoTPhPpa..s..........FPGLcPGD+WClCAsRWhcA......h........p...........s...........G........h..AP.VhLpATHppsL-hlsL-hLppaA.h............................	0	60	121	149
+9829	PF09997	DUF2238		Predicted membrane protein (DUF2238)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3647)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.30	26.30	26.40	26.90	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.88	0.71	-4.80	67	737	2009-01-15 18:05:59	2007-07-30 16:36:24	4	1	709	0	132	449	45	140.30	50	68.56	CHANGED	sllshslLhhoh+.+F..hoshsYhLlhlahhlhhlGuH.YTYAcVPhhsW........lp-hhGhpRN..pYDRluHFh.Ghl.Ahsh+ElllRpphl......ps..thhhhhslshshulSAhYEllEWhsAlhs.G.csutAFLGoQGDlWDsQpDMhhA	...............................................................llllslLlsTt+.Ras.L.TsLhYsLIFhasllLhVGGp.YTYAcVPls...............lp-hl.Gh.o...RN....sYD+LGHFhQGLlPAlls...RElLlRthhl........+s.tthlsFLlsslsLAlSAhYELIEWWsAlsh.G.puA-s.FLG..TQGD.WDTQpDMhsA.................	0	36	83	113
+9830	PF09998	DUF2239		Uncharacterized protein conserved in bacteria (DUF2239)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3644)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	35.60	29.20	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.27	0.71	-4.68	37	209	2009-01-15 18:05:59	2007-07-30 16:36:37	4	3	197	0	74	206	12	178.10	51	91.18	CHANGED	tsaTAFpGpRRlAoGsLh-VALAl+...tths.tsssuslLlFDDsTGRslDlDLRGoss-lhARhs.sss......................stsut...........PR...GRGRPKLGVVAREVTLLPRHW-WLuuQPGGASsALR+LV--ARRsssspDRtRtAp-AAY+FMoAhAGDLPGFEEAsRALaAsDtsphsphhtuWPsDlRsHAhtLA	.......saTAFsGpRplAuGsLspVAlAlKpths....ttssuslLlFDcsTG+slDlDlRGosp-lhuRhs.s....................................tsttsR..GhGRPKLGVVAREVTLLPRHW-WLusQPGGASVsLRKLV-cARRspsst-+tRtAp-tAY+FMSAhAGDhPGFEEAsRALaAsDtsthtphIsuWPsDVR-ashtLA.........................................................................	0	14	32	54
+9831	PF09999	DUF2240		Uncharacterized protein conserved in archaea (DUF2240)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3612)	Family	This domain, found in various hypothetical archaeal proteins, has no known function.	20.00	20.00	20.10	21.60	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.50	0.71	-4.75	16	65	2009-01-15 18:05:59	2007-07-30 16:36:58	4	3	65	0	51	72	48	134.50	29	87.88	CHANGED	pL+hsVAAPF+p..ptsspLscs-FlauLohDp+WhSP-pApcllctAtppGLLpp.csGslsssFDsuslplPhuF+Pscslh.................ppcssaEclLDtlsusuGls+p-lVuclNp.hp-pls..lsh-sAulllA+chGlDls....shhpcl	.................LphslAsPFcp..cupsplscsEFlhsLohDhcWhSs-pAKcLl-hAhpcGLlpc.csstlhssFDssplplP.sFpPs..tphh.................pccssF-cll-hlss.tGhs+pEslutlNp.hpcchu..lsh-sAAllhA+cpGlDlschhpc.h.......	2	10	34	44
+9832	PF10000	ACT_3	DUF2241;	ACT domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG3602)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241.	25.00	25.00	28.70	28.20	22.90	18.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.50	0.72	-4.25	48	273	2012-10-02 00:29:19	2007-07-30 16:37:16	4	9	265	4	97	252	79	71.00	38	48.18	CHANGED	MsGEp-LspLLpoMpPpLpsupaVFCols......shst.hsLpsl.usF+EpEGlTllLpcppAcptGL.saphsh+h	........MsG.psLptLLpoMsPpLpsGsYVFsTls............shssh.sl..pPl..uoFREs..EGLTLllppcpApptGL..shphhht................	0	19	48	76
+9833	PF10001	DUF2242		Uncharacterized protein conserved in bacteria (DUF2242)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4259)	Family	This domain is found in various hypothetical bacterial proteins, and has no known function.	25.00	25.00	80.60	80.40	22.70	17.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.53	0.71	-4.24	15	159	2009-01-15 18:05:59	2007-07-30 16:37:31	4	1	154	0	57	182	20	120.40	59	41.58	CHANGED	CEAARRALLSQGYllssucsctV-GpKsFQ.PcsDsHlplphRVVCAscshcushollFssALQDRYALKKosNSASVGVGuLGSlSLPhuSscDoLVKVuSETIsuupFY-RFFpLlc+YL	..CEAARRALLSQGYllouuc.sctV-GsKsFQ..PssDsHlpIsF+VVCAss..s.....tDGspShsaVNAlQDRYuLKKosTSASVGluVLGSlSLPIGSoDDShVKVASETlsuutFY-RFFsLV-paL..	0	5	21	41
+9834	PF10002	DUF2243		Predicted membrane protein (DUF2243)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4329)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	55.00	54.50	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.05	0.71	-4.41	22	165	2009-09-14 14:06:24	2007-07-30 16:37:41	4	1	162	0	73	156	1	137.90	42	79.08	CHANGED	uGlLlGlGLuuFlDtIlhHQlLQWHHhhsp.......................shclshl.DGLFHuhoalhslsGlhlLh...sh+pchsass+thhGulLlGhGhFpLh-GllsHplLtlHpV+....ssphLhaDlua.s.hGhlhllhGhhLlpps.pp	......uGlLhGlGLs.uFlDtllhHQLLpWHHhhsps.......................shclslluDGLFHAhoahhslsGLalLh...sh+R...+tsash+thhuulllGhGsFpLh-GllpH+lLtlHplRh................ss.shLh....aDlsa.l.huslhllhGhlLhhpsts.....	0	18	47	61
+9835	PF10003	DUF2244		Integral membrane protein (DUF2244)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5488)	Family	This domain, found in various bacterial hypothetical and putative membrane proteins, has no known function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.45	0.71	-4.81	79	402	2009-01-15 18:05:59	2007-07-30 16:38:12	4	2	380	0	144	369	562	136.80	29	81.50	CHANGED	LpPppSLs.cuahhhhsshsslshhsulshh.hhGu.WsllsFhGL-lhulhhAhphshRpupttEplslsstphhlh+psspGptpcachNshWs+lphctpst..h..tlsLpupG+cVclGsFLu.--RtsltppLppAL	............LpPppSLu.ptFhhhhsslsshshhhuhhhh.hhGA.WslhsF.hGl-.llslhhAFthsh..R.pApshEcIslst.phhlhchsssu.chppachNPhWsRlchtppsc................tlpltucGcpl.lG.p.FLs.c-RtphAptLptuL.........................	0	33	78	107
+9836	PF10004	DUF2247		Uncharacterized protein conserved in bacteria (DUF2247)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4304)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.40	25.20	23.40	24.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.82	0.71	-4.53	10	135	2009-01-15 18:05:59	2007-07-30 16:38:36	4	1	131	0	18	82	1	158.70	35	97.50	CHANGED	Mppsh...........hhtpthchsW+slhhGhppph.....lupcsVspaAhchlshuspspp...ElhLtlstchsspclsplLssLss........p.ppphptsh+KWh.alhLshlacspp-hsDsLcclEcIYADFsYPE-ltpFlpYMPscs...s..hs.ppNpcRlhspaccaLcp-puc	...................................................l........-hpsp+l+LSWcDIh...WGYpp....Kh.........luassls..saA.ch...hohu-pspt.....hcL.uh.ts+.sh.Elp.lL--Lus.............cpcsho.cpWL.all...Ls...cl.F.pp..+..cpap.-PLtcVEcIYsDFDYPE-I-SFVpYMPspDt..h.PstaohcENhtRLascWccYLssts..t......	0	4	12	16
+9837	PF10005	DUF2248		Uncharacterized protein conserved in bacteria (DUF2248)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4307)	Family	Members of this family of hypothetical bacterial proteins have no known function.	22.50	22.50	22.70	22.70	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.21	0.70	-5.52	49	377	2009-01-15 18:05:59	2007-07-30 16:38:49	4	1	332	0	127	355	70	318.00	43	91.29	CHANGED	pCssCup.laF-NstChpCustLGasP..pptplhslps.....ssps.....ap..................................................................................tha+hCsN.tshssCNWhlsscss...pshChuCchs+slPDLup...spNhttWpclEtAKRRLlYsLh+LGL.....Plhs+.....p..DsttGLsF-FLu-.....sssts.VhTGHssGlITlNluEADDucREphRpphsEPYRTLLGHFRHElGHYY...WspLlt.ss..shLttFRslFGD.EctDYutALppHYpsGP.P.ssWpppalSuYAouHPWEDWAETWAHYLHlhDsL-TAtuaGlplps...p.......th.........hshcPhpss.........shpp.llstWlPLohulNulNRSMGpsDhYPFVLsssVlcKLpFlHpll	...................................pC.pCsp...lhFENstChpCustLGa..pphtlhslts.....stts.......h....................................................................................t...........t.hphCsN.tthstCNWll..s.......ssss............ssh....ChuCphscphPs.ss...sts.htpWt+hEsAKRRLlhpLhcLtL.Plhs+....pp..DsptGLuFchLu....................sstpt.VhTGHssGlITlsluEuDDscREphR.hp.MsEPYRTLLGHFRHElGHY..Y.aspLlt....ss....s....hLptFR.plFGD.-ctDYstALp+HYpp.GsP..ssWp-sal.S.u.YAThHPaEDWAETaAHY.LHIhDsL-TAtuhGlsht................shp..........hshsshtss....sFpp.llp.tWlPLohulNplNRSMGpsDhYPFVLsssVlcKLcFlHpll..................................................	0	35	76	101
+9838	PF10006	DUF2249		Uncharacterized conserved protein (DUF2249)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4309)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.40	24.40	24.40	24.40	24.30	24.00	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.25	0.72	-4.40	163	821	2012-10-01 20:42:06	2007-07-30 16:39:03	4	21	465	0	266	571	35	68.20	30	60.34	CHANGED	plDlRsl..sstp+astIhsshssLtsGcs....hhllsc+-PhPLhtplptc......uh.saphhppssst.aclplp+	..........LDlRsl..sshp.astIhushssLpsGps....hhlls..s+..cPhP..L.htpLcpc.........Gt.paphhppusst...Wclpls....................................	0	76	190	239
+9839	PF10007	DUF2250		Uncharacterized protein conserved in archaea (DUF2250)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4344)	Family	Members of this family of hypothetical archaeal proteins have no known function.	24.40	24.40	24.40	24.40	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.90	0.72	-4.08	18	100	2012-10-04 14:01:12	2007-07-30 16:39:16	4	4	63	0	53	98	6	90.80	35	76.76	CHANGED	hcplhpc.hhLplLpHLccuslDYuKslschoclPLpcVpchLccLcchGLlE+ss.usolKpo-sKhKhupEVH+HHTYYpLoRcG-hlLRcl	...................h.....c.htlpILtaL.cc.h.s.sDY.u+h..lA+.....p.....h........chsLp-lpchlccLEchGLlERsp.up.......hl.Kps.....ct.......+h..K........pp.Es++...HHs....YYcLoRcG-hllRp................	0	15	32	47
+9840	PF10008	DUF2251		Uncharacterized protein conserved in bacteria (DUF2251)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4316)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	33.70	41.00	22.80	16.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.21	0.72	-3.87	9	172	2009-09-10 23:17:17	2007-07-30 16:40:18	4	1	172	0	20	82	1	95.30	56	69.74	CHANGED	hltupS..ps+huVVFEDDG-TGYFYALDhp.p.tpPIlDuLalYNVpslo..stctPpclpItWS-DGhpAhLlINGYPHAlFDFsphhGYs+otaP.P	........h..topu..cthhusVFEDDGpTGYFYAhD.p.....p......tssIlDALHIYNVE.DlS..Dt..H..I........PscVcIsWsEsuphssLLINGYPHAsFDFsppsGYCRsGFP.P.........	0	6	14	19
+9841	PF10009	DUF2252		Uncharacterized protein conserved in bacteria (DUF2252)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4320)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	22.30	22.30	22.40	22.40	21.70	22.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.18	0.70	-5.56	62	553	2012-10-02 22:05:25	2007-07-30 16:45:36	4	4	397	0	238	582	38	375.30	28	85.90	CHANGED	R....hspLlshRat+MusSPFuFaRGoAtlhtpDLss........ssssuhps.lCGDsHltNFGhau...ss-tpllFDlNDFDEshhGPapWDL+RLusSlslAucpp.uh.....................scppspphlpshspuYpcphpphuphshhphh..................hpspsspthlpchhc+App+.sptphhs+hophs........sthRhhp.psstlhtls................pstpptlppthppYhpols..sscp.hhsp....aplpDlAh+l.sGlGSlGhpsahlLlpuptps...c.sl..lLplKcAptSslstah.....tt.....tppGcRVVtuQRhhQusuDhaLGasphss..............+...s......FhlRplpshKsslsh..cp...h....st..cphtpauchhGtsLA+AHA+.us...css................hlsshhupscphs..pslscaAhpYAcQscpDattahcs	.................................................................spLlslRat+Mus..SPFuFaR..GoAtlhtt.DLsp.............................tsssuhtl.lsGDsHltNFGhas...ssctpllFDlNDFDEshhGPapWDl+RLusSlslAucpp.uh...................sppptpphlpshspuYcpphpphsphsh.phh.........................................................htsppspthlpchlp.+Appc..s......ptphhs+hTphs.t...........sth+hh...t..psshhhtls.........................psptt.tltshh..p.p..Y.h...po..l.......tst...th.h..hsp....aplhDlsh+l.lGlGSlGhpsahlLlpupsss.....s.sl......lLplKEAt.s..ushs.ah...............t...............tppGcRVVtuQRhhQssuDshLGas.p..hss...............+.s......................ahVRphpsh+tslch..sp.....l......s.....pphtthuphhutsLApAHA+.us....sss...................hlssh.h..u..p..s.cphc....pslspaAhtYuspsctDattahp...................................................	0	67	139	199
+9843	PF10011	DUF2254		Predicted membrane protein (DUF2254)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4325)	Family	Members of this family of bacterial proteins comprises various hypothetical and putative membrane proteins. Their exact function, has not, as yet, been defined.	22.30	22.30	22.50	22.70	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.94	0.70	-5.99	89	512	2012-10-02 20:27:15	2007-07-30 16:46:06	4	3	472	0	161	484	58	341.10	25	80.16	CHANGED	lppplWhhPslhulhullhuhlshhl-t....hhs..........hshhhtsss-uscslLoslAuohluVsshohSlhlsulstASuphoPRll.phhhpDpssQhsLusFlGoFlYuLlsLhslcssh.t................sspls.h.hhslllsllslhsLlhalcHlsphhplssslppltppsppslpphhpp.thss....sspsth.ts.......................ltutpsGYlQtI-hpsLtchApc..psshltltstsGsFVhtupslshh.......................pth..sccptcpltps....hslGppRohpQDspFGlppLsEIAhRALSPGlNDPsTAlsslspLsplLsp....................h.sshhtspps...sRlhl.shs.h..pcllcpuFstlpp.uussht.....Vhh+lhpsLtpl	...........................h..pplWhhsshhslh.ulhhuhlh.hh.hct.hhs............thhhps.ss-sscslLssluuohlslsshshSlhlsuhs.AouphoPRhh.phhl.c.Dp.ssQssLuhFluoFlaullslhslptst.st..............hspls..hhhslhlhhls..lhsllhalp.+lsp.hplsphhsplpptsh.p.s.lpphhtp.s..phs...s..............s.t..t.......t.ths.....................................lhutpsG....YlptlchspLtp....hs.pp......pph.plhlhstsGsalh.utslhhl...........................................tt.s....p.p..h..pp....lhps....hhlutpRohpQD.pFulp.lsEIAhRALSPulNDPsTAlpslsplsplLsh...............hht.t.sp.hhh..ttt................plhl...hs.h..pchlcssFs.ltp.uuspht.....VhhplhpsLtt..............................................	0	56	107	135
+9844	PF10012	DUF2255		Uncharacterized protein conserved in bacteria (DUF2255)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4334)	Family	Members of this family of hypothetical bacterial proteins have no known function.	29.70	29.70	29.90	29.80	29.00	29.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.41	0.71	-4.13	14	98	2009-01-15 18:05:59	2007-07-30 16:46:22	4	3	93	0	40	99	4	111.40	34	86.82	CHANGED	--Lc+IspA-DL+IAPaRcDGpThuTPTWIWsVhV-scLaVRuYpGpsScWapuAlsQ+AG+IpAuGhst-VsF-sl...Dssls-pIDsAYRsKYup.StYlsPMls.tcARuATl+lh	....................-Lsplspu--lpluPhctDG.ThtpsshIWsVhlsscLYVRuhpGpp.SpWYpuAhsppsG+IpsuGhphpVsFtss....DttlpsplDpAYRpKYut..s.hlss.Mls.ttsRsuTl+l.h.............	0	16	31	34
+9845	PF10013	DUF2256		Uncharacterized protein conserved in bacteria (DUF2256)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4338)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	25.20	26.80	24.60	21.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.61	0.72	-4.20	71	341	2012-10-03 05:12:49	2007-07-30 16:46:39	4	2	336	0	116	321	140	41.70	59	69.36	CHANGED	t+KspLPp.KhCslCtRPFsWRKKWp+sW-pV+YCS-RCR..+p+	......+KspLPp.KlCsVCtRPFsWRKKWt..+sWD-V+YCSERCRRp+.....	0	42	83	101
+9846	PF10014	2OG-Fe_Oxy_2	DUF2257; BsmA;	2OG-Fe dioxygenase	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4340)	Family	This family contains 2-oxoglutarate (2OG) and Fe-dependent dioxygenases. It includes L-isoleucine dioxygenase (IDO) [1].	23.10	23.10	23.40	23.30	22.30	22.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.20	0.71	-4.92	113	432	2012-10-10 13:59:34	2007-07-30 16:46:58	4	4	397	2	130	367	28	193.40	28	79.36	CHANGED	htssass.LshDpahsst...aRhRRaupathpsss......lhth.......scpsahQssp..aNth..pGul.RpFpsls..sshhpssshppllphhhphhsthp...........pshplplHQhRlpsssst...upsoPEGlHpDGhDal.hlhhlsR.pNl...pGGpopl...........asssppthhphpltcsh-slllsD..pclhHtlTPlpshsssp.......uaRDlLlloa	..........................................................................................tssasp.LshDsahsst........aRhRRYuphthpssp..........lh.h.........scpsahQosp....hNth..pGslhRpFpslp..sshlpssshppllthhhphsshss............shplplHQhRltAs.sp....u.ssPEGlHpDGhDal.slhhlsR.pNl.....tGG-shl...............hps.s.p.ptshhhplhcsh-shllsD..pclhHssoPlpshsssp.......uaRDlhVlT............	0	28	70	103
+9847	PF10015	DUF2258		Uncharacterized protein conserved in archaea (DUF2258)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4345)	Family	Members of this family of hypothetical bacterial archaeal have no known function.  Structural modelling suggests this domain may bind nucleic acids [1].	25.00	25.00	61.80	61.80	22.80	18.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.44	0.72	-4.17	10	57	2009-01-15 18:05:59	2007-07-30 16:47:08	4	1	53	0	39	54	0	76.90	44	43.67	CHANGED	ELsTGlVIAuuYADKLRRVlFAsl.....pstlssc-llRssuELN+pLF-hLVpchclsKhDVVRIpV-..Yslc-uKlha	.ELsTGllIAutYADKlRRshaAth.....pphlsp-pllRssuELN+tLYcpll.chplsKhDVVRIsV-..aclcss+lha.......	0	9	18	27
+9848	PF10016	DUF2259		Predicted secreted protein (DUF2259)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5497)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.70	26.20	19.10	24.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.14	0.71	-4.59	13	87	2009-01-15 18:05:59	2007-07-30 16:47:21	4	2	83	0	35	83	3	188.10	26	82.36	CHANGED	AFtpaGlpDGSGFPYAslahlDstpspFl.sushRsphsc-su.......sLsthhpcspppspshh.stthpscsshhss.sshoEh.........oucsaplhlhs+ss.sshctshpLplpp...hshs.st.htsht.cshGFpL..htt.suspsphlpts+ulP.uRsCshsYcIcpVhl...psspsshlhlltscphGFEG.PstR..alslss+	.........hFtpYGhp-G...h.sYuslYhlDlspssFlpu.ushppphpccht.......sLh.p.hhpptphtspphthsth..hpup.hhhhsp.s...lsEh.........................suspaplhlshch..s...tthsssaplpLp.....................................phssushpc.tlpss+s.sh.RtsshsY+Icclhl....sspsshlhllchh.hs.pG.tshR..ahs.sh+........................................................................	0	11	22	26
+9849	PF10017	Methyltransf_33	DUF2260;	Histidine-specific methyltransferase, SAM-dependent	COGs, Finn RD, Sammut SJ	anon	COGs (COG4301)	Family	The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring [1].	23.00	23.00	23.20	24.50	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.37	0.71	-4.25	314	818	2009-01-15 18:05:59	2007-07-30 16:47:50	4	20	692	0	412	836	262	124.80	34	32.13	CHANGED	GlDLh....K-sshL.sAYsDutGVT.....AtFNhNl.Lp+lN+cLs...uc.............FchssFcHh......Aha..sspps...c.lEMaLhupcspsVpls......s........hsh..pFttGEpI+....TE.ShKash.....cphptlhpp.................AGhpstphWsDsps.hFulhl	...............................GhDLsKDsshLhtAYsDutG..VT.................AtFNhNl.Lpcl..NccLs..u-.............Fchcs.FpHh........Aha......ssppp...R.IEMaLhupcspsVpls.........t.........shthpFptGEplc....TE.ShKas......cphpthhpt.................A.GhphtphWoDsps.Fulh........................................	0	120	255	343
+9850	PF10018	Med4	VDRIP; 	Vitamin-D-receptor interacting Mediator subunit 4	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4552)	Family	Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter [1][2].	25.50	25.50	25.60	26.10	25.20	25.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.32	0.71	-4.89	33	292	2009-01-15 18:05:59	2007-07-30 16:58:54	4	8	248	0	212	284	0	182.90	23	60.52	CHANGED	hphhppLlst-cpLppslcpLpcapchppclppLcp-spplDppl+pllcpLtshcppLpshs......t.pp........................tshsptppppls......sc-LLcYA++ISKaops........................................................................................htPssah........t..h.Pa.PtE-phRtGhLuphshtss...t..h.pstpp.....................................ssstsptpsptttpppss	................................................t.thhphLlptDpplpptlch.........h.tpptph.ppchppLcp-scphD.p....c.lppl.cpLpcscp.Lssss.......sppch..........................................pshtpspcttl..s......sc-llcYA+R.ISttsts....................................................................................................................tP.sah...........t..hhPa.Ps-.phRtGhLuphp...st.th.............................................................................ttssttthttt..............................................................................	0	60	104	170
+9852	PF10020	DUF2262		Uncharacterized protein conserved in bacteria (DUF2262)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4296)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.60	25.60	25.60	26.20	24.70	25.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.99	0.71	-4.01	50	250	2009-09-11 11:06:32	2007-07-30 17:17:49	4	5	177	0	44	249	1	141.30	24	59.29	CHANGED	p-phlGsFphs+pht..ta-uphphh.spp.lplph...............t.stpccpphpp...slp....thcc...................l.......hpphcchccpl+phsucc..ll-lAN-.Whps..................s-p................................loc-cFhpplpLs...slslpscu.........shphaasDs....DhFhGHslhVpsshstshp..susl	.......................................................hGphhhs+php...hapsphphh...spp.lpl.h..................stppppthpp...hh.pthcc...........................hhtphcpac.pch+phhucc...LlchAN-.Whc.p..................c-pt...............................lTcEpFtpplp..lp...slslptss.........shshaacDs....DlFhGHsIhlshshctslhsApl..................	0	24	33	34
+9853	PF10021	DUF2263		Uncharacterized protein conserved in bacteria (DUF2263)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4295)	Family	This domain, found in various hypothetical bacterial and eukaryotic proteins, has no known function.	19.30	19.30	20.80	19.80	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.92	0.71	-4.21	20	353	2009-01-15 18:05:59	2007-07-30 17:18:14	4	11	248	4	211	358	19	139.00	26	40.87	CHANGED	ApETlsll...........ssGhYlsssustlslptphctu.hpsophasPs.h..............s..pTtlcVssssThsuA....ppLsp........ssppVslLNFASA+NPGGGalsGApAQEEsLsRsSuLYhsLhp.....h...Ythp+tppshhYoDth...IYSPsVPlFR-c	.............................................................................................................p.hh...t.........................................tt.splpVh.s.tsolpuA..................hpLtt........................tttpluVLNhASsppP..GGG.ahsG.At.A.QEEsLC+pSsLhssLpp......h...Y......p...t..........t..t.....hYs.th..................IYSPsVhVaRs.......................................	3	74	132	181
+9854	PF10022	DUF2264		Uncharacterized protein conserved in bacteria (DUF2264)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4289)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	30.60	26.80	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-11.98	0.70	-5.80	52	781	2009-01-15 18:05:59	2007-07-30 17:23:14	4	6	507	0	203	599	25	287.20	29	59.32	CHANGED	psRpp.............hhpshpplhpslhshh.upspt+hsh.spossta....sppss..s.lEuauRsLhGlAPhLpt........tt........phh-hhhcultsGsDP...pss-YWshhpst.s...QplVEsAsluhuLhhu.ctlWpsLsptp+pplhpaLpphp.phphspsNWhhFplhlphsLpph.Ghth-p...tlcpslpclcp.aYl...........GDGWYsDGs.........................thphDYYs.uauhHhhhlhhsphhscpc.t.........hhpphppRtpcFuppa.+hhus-Gsh.saGRSlsYRhAshuhhuthuhtph....tsl.s.Gpl+shhppsl+hahsps.shasps......GhLolGashsp.thsEsYsusGSsYWuh+uF.lsLuLPtscsFWoutppshs	.....................................t.sht.h.thh.phhtsl...h.s.tt.....thph.stttshh............sptts..p.hEuhsRshhshushht.......................................hhphhhpulhtGsc.P...pp.s.pY.h....s...ht.sh................QhhVEhu.luhsLhhs..p.hWp.Lstppppplhpah.t.p.hp.php...hs..sNWhhFplhlphhLpph.Gh.hst..............hp.thth.hc.p..aYh...........GsGWatDGs.........................th..thDYYs.uashp.h.h..hhphh.ct.t..................hthhhpRht.astt...h.hhhs.p.....G.th...hGRShsYRhA.ht.huthsht........th........h.s.G.h+..thhtttl+hahpp...thhstp......GhLolGa.h.....h...p.h...hu-sYsusGSsYWuh+sF.lsLulPtscsaWps.tpsh....................	0	61	135	180
+9855	PF10023	DUF2265		Predicted aminopeptidase (DUF2265)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4324)	Family	Members of this family of bacterial proteins comprise various hypothetical proteins and putative aminopeptidases. Their exact function, has not, as yet, been defined.	25.00	25.00	26.30	25.30	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.99	0.70	-5.30	26	162	2009-01-15 18:05:59	2007-07-30 17:23:26	4	1	160	0	64	186	97	334.50	43	92.38	CHANGED	hhhlhhshhLuGCss.......luYYhQuspGplplMpttcPlcchlsDs..sssstL+pRLthupphRpFAsp-LtLPDNsSYRpYA-LpRPaVVWNVhAsPchSLp.+pWCFPlsGCVuYRGYFspssA+stAspLpppGhDstVtGVsAYSTLG.....WF....sDPLLsTFlt.as-s-LApLlFHELAHQslYlpsDTsFNESFATsVEp.GlcpWL...A............ppusssscspatthcpRRpQFpuLlhsTRpcLptLYtsshsssptptt....KtthhpphRpcYupL+sp.W..................uGhuuYDtWhspslNNAcLushusYsphVPAFpuLacpsstc............WsRFYsuVcpL..upLPts-RctsLp	...............h..hhhshhLuGCss.......luYYhQ.spGphpLlps+cPlsclluDP.....spsstL+p+L..tpupphRpFAoccLtLPDNpSYRhYA-LsRPaVVWNVhAsPEhSLpshpaCFPlsGCVuYRGYaspusA+upAstL+tpGhDVhluGV.AYSTLG.....WF....sDPlLSohlt.as-...t...cLAsLIFHELAHQphYlcs....................DTtFNESaAohVEppGscpWh....t...............tp..u..t.s..stpsph..pp...tRRpQFttLlLsoRpRLcsLYss.s..l..s..sstp...Rst....KsthFppLRpcYtpL+sp..W......................uG...ptaD.t.Whsp.P..h...NNAcLhshuhYcpaVPAFtsLF.cps.sGD............WspFYstVcpL..up..LPh.tpRptsL...................	0	16	35	51
+9857	PF10025	DUF2267		Uncharacterized conserved protein (DUF2267)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5502)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.20	25.20	25.20	28.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.64	0.71	-4.06	135	355	2009-01-15 18:05:59	2007-07-30 17:24:29	4	7	195	1	178	362	14	123.70	24	78.49	CHANGED	chp.palpclppcssh.ss............pppAhpsscuVLpsLtcRLsscputcLAupL..............Ph.lpshhhp........stttssp.........hstccFlp+lup.h...............pt..spt........sucpsspAVhsslpctlstsch.cclh.spLP.....p.shcpLa	.....................hppalpplppcssh..s............cppAhpsscuVLpsLt-RLssp.......pstcLuupL..............P..lpshhhp..............sttsstp..........hshccFlp+lup..h................ss....sst........ssctsspAVhsslpctlstsph.cclhspLP.....p.shptLa...................	0	41	114	159
+9858	PF10026	DUF2268		Predicted Zn-dependent protease (DUF2268)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5504)	Family	This domain, found in various hypothetical bacterial proteins, as well as predicted zinc dependent proteases, has no known function.	23.60	23.60	23.60	23.60	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.09	0.71	-4.93	29	528	2012-10-03 04:41:15	2007-07-30 17:24:48	4	1	428	0	84	353	10	181.50	33	68.64	CHANGED	happhpcphpphtphapts.slslh.......lh.sstpp.hht.phGhpussuhsshlhlh..lssshsps.....clpullAHEaHHssRhphhphs.tshTLh-sllhEGLAEpastphaGcphhusWss.hspppLpphhpphlcpphchp...shtphsshLaGsthut........hPthhGYulGYplVppaLppsst.oltchshhsucpIlc	.........................................................................apphpp.hchhhs.hpt..sls.........lLl.uss.tp...hh.........p.h.sht.ussu.hsshlhlh...lssp.ols........phpullAHEhpHshRhp..h...............l..chp.....................s..hoLh-hllhEG....LAEpaspplaGc....tt.h..uPWso....ths..............p......ph.............hhcp...hltpplplp...thhchtsaL..a.G.....hsp..............hPph...hGYAhGY+lV+talppssh...sh.th.hsls.ApcIl....................................	0	26	58	68
+9859	PF10027	DUF2269		Predicted integral membrane protein (DUF2269)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5528)	Family	Members of this family of bacterial hypothetical integral membrane proteins have no known function.	27.80	27.80	27.80	27.80	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.06	0.71	-4.43	56	382	2012-10-01 21:57:53	2007-07-30 17:27:15	4	1	316	0	152	427	95	142.60	26	94.20	CHANGED	hlLKhLHlluuslLhGoGhGhAaahhhAp................................cotcstslAtss+hVVhuDal..FTssusllQPlTGhhLsals..GasL..spsWlhhSlsLYlluGshWLPVlh.lQh+hp...chApsAspssts.ls.tYhphh+hWhhhGhPAFh.uhlsIhaLMVsKP	...........h.hlchlHlluuslllGsshsh...A.hhh.h.h..Ap................................+su..s.s...ss..hu.t..s...t+h.ls.hschh.....h..h..ss..s.slh.PloGhhlsthh.....Gh....sl....sp..s..Wl....lhSl.sLasl.u.u.h.h.Wlsllh..hphcht..........chAtt..utt..tst.......ls.th.h..phhp..hhhhhuh....uh.h...shlslhhLMlhKP..............................................	0	36	81	113
+9860	PF10028	DUF2270		Predicted integral membrane protein (DUF2270)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5530)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	40.70	68.60	22.80	21.10	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.06	0.71	-4.81	19	87	2009-01-15 18:05:59	2007-07-30 17:27:43	4	1	68	0	51	93	11	180.30	40	77.60	CHANGED	uHLYRGElsRussWRoRLDpTTNWAVsssussLShuFuospus.hslLlshlhlhhFLhlEARRYRaa-laRuRlRhhEpsaaAshLsstths.css..WpphLApDhp+Ppa+lShhcAluRRLRRNYhaIhhlLhlAWhsKlslHPh.........stShsphlppAulGPlPGhhllsssshahhshlslul	.hHhYRGElsRhssWRsRLDpTTNWAlsshAAhLShuhSossssHhsLLhuhhllhlFLhlEARRYRaaDlaRuRVRhlEcsaaAthLss.tss.sss..WpphLup-hcpPphplohh-AluRRLRRsYhalhhlLLlAWlhKls..s............stshsphhpsAulG.slPGhhVhsslshaYsshlsls.h....	0	9	29	42
+9861	PF10029	DUF2271		Predicted periplasmic protein (DUF2271)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3656)	Domain	This domain, found in various hypothetical bacterial proteins and misannotated lysozyme proteins, it has no known function.	27.30	27.30	27.50	30.60	27.10	27.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.78	0.71	-4.68	62	357	2012-10-03 16:25:20	2007-07-30 17:27:59	4	5	342	0	130	295	47	138.00	31	75.56	CHANGED	Asshpl..slplsplsstpactPY.....VAlWlpsu.csphspTLtVWhpps........+Wh+-.lRpW..WR....csucptp..lDGloGAT+ss.Gphthshsssts.hssLhsGpYplhlEsuRE.sGscph.....hclshsl.....spststphpGpsElusl	...................thslslpl.pLssh.thctsY.....VAlalpcs.puphstoLhlhstps.................KWhcc...L+pW...aR....tsu..ts..sp...lD...GlTGAThsu.Gc...shch.shchscsLhsusYplhlEuAhE.ctscph.........sclshsL.....ssputshpspGpp.lus..............................................................	0	37	87	110
+9862	PF10030	DUF2272		Uncharacterized protein conserved in bacteria (DUF2272)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4322)	Domain	Members of this family of hypothetical bacterial proteins have no known function. However, given its similarity to the CHAP domain it seems likely that this is an enzyme involved in cleaving peptidoglycan.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.56	0.71	-4.82	13	136	2012-10-10 12:56:15	2007-07-30 17:28:21	4	5	128	0	47	156	22	179.70	29	62.05	CHANGED	EssshuhpplutYW...t-ussscshhsGs.su.....................asWSAAFISWVMRpAGlss.pF.hussHusYlssAh...psGhsshshhth-PssttPcPGDLlCssRGRsphlsasuhhssss......asuHCDIVVu....sDs..pplpsIGGNVpsSVuMcplsLscuGpLsss...............................sss+hsWhllL+s	....................................................t.hhhthsttYW......p.shht..hst.......h..h..s.....................sWSAAFISWVM+pA....G..lss...Fshu.ss.H.hpYlpsAh.......pss....p......sh.hhh-s..ss.htP.psGDLlChsRups....h...t.h.ss.h.tshs...........hstHCslVVu....scs...cplphIGGNV..t.soVs....hpphslspt...Gpl....................................shh.WhhlLc.............................................	0	8	32	40
+9863	PF10031	DUF2273		Small integral membrane protein (DUF2273)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5547)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.40	25.40	25.50	25.80	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.10	0.72	-4.35	33	978	2009-01-15 18:05:59	2007-07-31 08:34:00	4	1	886	0	111	282	4	49.80	39	73.55	CHANGED	p-hhppaph.llGullGhllAllhlohGFaKslllllhsslGhhlGhhl.cp	...........phhcpa+h.IIGuLlGLllAlLhlolGFaKTlllllLshlGlhlGhhl-......	0	47	72	97
+9864	PF10032	Pho88		Phosphate transport (Pho88)	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4554)	Family	Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance [1][2][3][4].	25.00	25.00	25.60	33.50	21.50	24.50	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.15	0.71	-5.08	27	200	2009-01-15 18:05:59	2007-07-31 08:46:54	4	5	167	0	148	182	2	178.70	39	92.04	CHANGED	MsPtloNlhlhLlhMQlu++..lsh-D.PpllhhlRhhYlsspslhhslYhasph+IspKN.....DhTsLKYV-PusPhuutt.....cs+hssTTV+-YDlpplpph.h+uhhhGluMMuFMHlYhKYTNPLlhQSI.slKuAhEuNlV+IHlaGpPApG-..L+RPF...Ktssuhhuuhtt..upspoDKpol-sAEpsstu..GsKs-	......................hsPtlpNlhlhLshMQlu++..lsh-D.PsllhhlRshYlsopllhhslYhYlptpIspKp...........Dh.TsL...K.YVEPs.sh..uupp...............E.+hlsTT...Vp-YDhpplcph.l+u.hhGluM.MuhMHLYhKYTNPLllQSIhslKuAhEuNlVKIH.laGpPApGD..LcRPF...K..ts.suhhutht....t...stspoDKtul-tAEcshtuGhK...............................................	0	57	95	131
+9865	PF10033	ATG13		Autophagy-related protein 13	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4573)	Family	Members of this family of phosphoproteins are involved in cytoplasm to vacuole transport (Cvt), and more specifically in Cvt vesicle formation. They are probably involved in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage [1][2][3].	25.00	25.00	26.90	25.50	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.60	0.70	-4.94	38	337	2009-01-15 18:05:59	2007-07-31 08:57:08	4	5	247	0	227	334	3	203.60	28	31.14	CHANGED	IppFahKuutlIlpSRl...............................hsspssst+sN+W...................FNlcl...p-psthp-pL+hW+s.tshtp...............hPPllIEsaLDhptLssspslhh.Dttsp.h.s.tu.......................sp..-llLERW.hl-hc.............sttttssstssphsplYKc....sllLFRSLashs+lLPAa+lp+ph..........ttt.......................slslthRlh.........sGp..h.stsp.sLopPl...hst.p...............phc...phpFsslpTshGpLplsVsYRssscF	..............................................................lp.FhhKssplIlpuRh.....................................................................t...s...spsss.s.psscW....................F..Nltl...c-h.st.h.pcph+thhs..tth.s............................hh.shslElhLcs......................................................................sctsphlLEpW.plchs..........................................pp..s.sp.phpsh.slY++...................hhlLhRSLhshsRlhPAa+lt+ct..............s.......................t.phslhaRlh...............up........s.hsp...................................shp....phphusltTshG.plslSlsYRhshtF.........................................	0	67	122	185
+9866	PF10034	Dpy19	DUF2211;	Q-cell neuroblast polarisation	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4587)	Family	Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants [1]. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.	20.40	20.40	21.20	20.70	18.80	20.30	hmmbuild  -o /dev/null HMM SEED	642	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.31	0.70	-6.35	12	344	2009-01-15 18:05:59	2007-07-31 08:58:36	4	6	92	0	200	352	2	453.40	30	90.58	CHANGED	Alhsuhlah.altplaEN-paFSpluplEREhuFRTEhGLYYSYYKsll.cAPSFhcGlahlhpDshTEYPpsINsLpRFNlYPEVlLAhhYRsatthhphh..................................-PshFYltslFhLpGlhhshhahhuhhLS.GShLuGllsshhah..FN+s-sTRl.aT.PLREsFuaPFlhhQhhllThhL+p...ptspptphlhlhhoshh...FhLsWQFuQFllhTQlhuLFshashuhlsss...Khppllhhhh.......hShhlsalLhF....GNsMlLsShhhS.llulhslhtl.................ppp...hsthhh...clhhhllpshhhhshTlhLphhhpplL............shpDDtHlhshlcuKa..tsapsFcohlYsC.usEFshlptcs.h+lspThLlshhlhhhshhh.............hphhtsh...........................................................................hthlsppp.p.....................pcsp.t.csE................................................................................llYpslQhlsFshLAllIhRLKhhhTPahClhuuL.lCSppl............a.........lhppl+ht.............ssshhllshhhhphhsslppphshlsEass.sp.pELlpWIppsTp.sAVFAGuMsshAsVKLoTtRslVNHPHYEcsslRcRTchVYphYS++ssc-V+cpL.hphtssYhIl-tshCsp.Rs+s....GCsh.-lhDhcsscstsp.............s.hCpt..lttc..s+......P...aFspVFp.NppYpVhKl	.....................................................................cpph.h.tc.uhYYsaac.hh....tu......sh.t..uh..lh.sp.o.........................................lNhlpph.lh.Elhhu....h.aphh.......t.h..............................................................pPh.FYl.hlahhtuhhh.hhahhu..........hhhS..so............h..............uGhlss..hhah..hN+h-sTRl.as.PLREsauhPahhhQhhhlThhl+........................t...h...........hh....h.h.hsshh...h.h.Wpaspahhhh.Qhhslahh..hsh......................ph..lhhh.h.......huhhhshhl.F.....N.hhL.o.h.s..h.hhhhhhh..........................................................................................p.............t..h.....ph.h......hh.h...hhhhhhslhlp.hhp.h.hh................htpp...+h..phlts+....h......htsFph.hh.hC.t.thth...th.....ph..po.lh.h.hhhhh..hhh.............h.hh..h...........................................................................................h.............................................st................................................................................................................hhaphhphhhhs.huh.h.th.Khhh..hshhChhuuh...ls.S.ph.................................................ht.ht............................h.hhhh..h.h..hph....sth.tph......htEa......s.sp..pLhpWIp.p..s.....t.s..............shuGs...hhusl+L.............s..................s.......hh.lsshPhYpptthht.Rs....h.Ythaupts.pplht.h..hthtspahllp..hC......t.............sCph....phhD.tp...s...t..tt..........................................hCt...h..t...........................F.hha..Nt.ahlhp..........................................	1	55	69	126
+9867	PF10035	DUF2179		Uncharacterized protein conserved in bacteria (DUF2179)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4843)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	20.90	20.90	20.90	21.00	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.38	0.72	-4.36	189	5446	2009-09-10 22:22:21	2007-07-31 08:59:57	4	5	1792	2	766	3177	158	54.80	32	19.63	CHANGED	RGlThl.pupGuYot....pc+plLhsVls+p-lhcL+pllpclDPpAFlsl.t-sp-VhG	...........RGlThl...pupGuYop......pc+pllhsVls.+.pEhscl+pllpplDPpAFlsl.t-spclhG............	0	297	555	661
+9868	PF10036	RLL		Putative carnitine deficiency-associated protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4380)	Family	This family of proteins conserved from nematodes to humans is of approximately 250 amino acids. It is purported to be carnitine deficiency-associated protein but this could not be confirmed. It carries a characteristic RLL sequence-motif. The function is unknown.	22.50	22.50	24.30	24.30	21.40	22.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.45	0.70	-4.95	15	168	2009-01-15 18:05:59	2007-07-31 09:07:27	4	4	123	0	110	159	3	220.70	42	95.44	CHANGED	hh+.RtLssLpas.tssthshs-cc-FtsllhWLEDQKIRhYphEDRppLRplssuc...WscsapKYhpDlphPh.........clps+pptlsWLLshAl+L-YtDss...............ts.pstpch.pcpp+psp.pscpsp..sslshssscFptGlppLAstLsltt..............................Hs........DplVhLcuss+llpE+Lspcstscsslp...s.Ph..-p.tslGhss................tDssLccAApILRLLpIpsLRcLQocINEslVuVQslTAsP+TDs+LG.KVGR	.......................................................................hc+KLpALsY....sshsh..p..DcpcFRshllWLEDQKIRtYpI....E-RssLRslpusc...WsphapK..YlpDlssPh............phpp+.p-tl-WLLuhAV+LEYsDss........................pphps....spptpss..sstspsspPl....sl.Dhs..s..s-F+sGVhsLAslLpIpp....................................Hs........Da..LlhLcA....lphl..lp-+Lstcu..lscssps.....ts.......h...shsh.c...c....t.lGFss............t.Dss.lspAApILRLLaIp-LR-LQTcINEsIVAVQslhA-PKTDp+LGKVGR..................................	1	42	52	82
+9869	PF10037	MRP-S27	MRP_S27; 	Mitochondrial 28S ribosomal protein S27	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4570)	Family	Members of this family of small ribosomal proteins possess one of three conserved blocks of sequence found in proteins that stimulate the dissociation of guanine nucleotides from G-proteins, leaving open the possibility that MRP-S27 might be a functional partner of GTP-binding ribosomal proteins [1].	25.90	25.90	25.90	26.10	25.80	25.60	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.47	0.70	-5.56	8	150	2012-10-11 20:01:01	2007-07-31 09:08:46	4	3	86	0	85	150	0	316.00	26	84.07	CHANGED	MtsShlppuhhhu+hh........uu+RhLLSuAYssuchWEuRcpEPhpLA.s...LAphh-psa-RKLPV....SSLsluRFlDNIuSR--..lDpAEYYLYKFRHSPNCWaLRDWTlHoWIRQCLcasupD+uLYTLcN+VQYGIFPDsFTFNLLlDsaIKcG-aKsAsSVVpElMLQEuF-hPSTphLSLYu.Lhpa...........LAspPsLo.......hpEERslGASLLlsGhKQ-solGhSup.LhGhALLGKVEhppGl+AVa+sMPLhWusGYLs+ulplhEtlAos..sltLuc-sLclhpslLc.....sLou.sDussptp.pcs.-sttpp.....plsEc...-psEpuK.......LspYucpFpch+spLpsts+l-scul.s.s.thlpE+LsssEp.DlchYEp+lptWphEpc...............pLIQREccpREpA-pE.....atstpss+su	..................................................................................................................................................t....tt..h....s.hslsh...h........ls.hpsp-c..l-.sc.hla........+..............aRppspshhltshsh.p.shlR.hLchst.p-pAl.hLpsplpYGlFsDsaoaNlLhD.hlcctpa.csAhpVlh.clh.Q-sh.ps........sTphLulhs.ha+h......................t...........p..............p-.hp..htsthlhs.hhpcp.shhp.p.lhGhshh..hhsp..h..t...s.ttlhpt...s.hht.shhtch.pshphhtt.......t.t.ltp-...slphh....tthhp..........th.......t.....t.....t..p......p..tt.t.t............p..pp...pp...hct..h............l.p.hp.apt...hppphpthhp.p.pth.......h.pph.thpt...th.tpp...h..c......................h.h.....tcpp.......p...p..................t......................................................................................................................................................................	0	20	25	52
+9870	PF10038	DUF2274		Protein of unknown function (DUF2274)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5639)	Family	Members of this family of hypothetical bacterial proteins have no known function.	23.80	23.80	24.00	25.20	21.60	23.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.00	0.72	-3.85	42	198	2009-01-15 18:05:59	2007-07-31 09:10:14	4	1	125	0	104	209	23	68.60	45	84.66	CHANGED	Mo+LKLGsls.D-+PVKlTlELPAslHRDLsAYAclLuppsGps..scPs+LIsPMLpRFhAoDRuF..sKAR+	..............sKL+LGsls.-ccPVKlTlplPAuL+....pDLstYAtlhup....p.hGps....s-sscLIs.MLcpFhAsDRuF..tKu+........	0	15	61	84
+9871	PF10039	DUF2275		Predicted integral membrane protein (DUF2275)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5660)	Family	This domain, found in various hypothetical bacterial proteins and in the RNA polymerase sigma factor, has no known function.	24.60	24.60	25.20	26.40	22.60	24.50	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.27	0.70	-4.44	7	40	2009-01-15 18:05:59	2007-07-31 09:10:48	4	4	40	0	13	40	0	204.20	22	55.95	CHANGED	.cpt..sDhhcphhu..tc.s..p.p..hh.thahphh+thultulhlhhhAsshhs.h..........hplsphslsplt.cshhslpsp..............hp.thhsls.tuhut...hpssut.uppssssslcplps.shhththsssh....sh.lttshsspppsht.h.ththhssthtshsts..............hhhsuchccptttlhhut..................shs.slpc+ts.cph.t..........st	............h.......DLscthhu..t..s..sspt.thh.thh..p+.hh+thAlhslslhhlAsss.h..h...........hplsshshshloscshtshpspa.............hpcsst.lshhshu....ltsGsh.utssuhsplsthhuhshhshhlsssh..............shpls.tshltsc.sh.hs..Lt.........hshlsthh+shutT.................hh..tphpph..hh...s............................................hs......................................................................................................................	0	4	9	12
+9872	PF10040	DUF2276		Uncharacterized conserved protein (DUF2276)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5551)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	25.00	25.00	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.53	0.71	-3.90	63	439	2012-10-01 21:23:39	2007-07-31 09:11:45	4	2	340	0	176	405	13	121.00	21	43.08	CHANGED	lpFhTPTthp..............cspthh..hPps.ttl.hpSlhc+asshss.hth..................stphht.hhspslplhshp.l....+shphph.........pttthsGhsGpssapht.......tthhpthttLlphupahGlGppsuhGhGpsc	......................................................................lpFhTPsth+p....................puphh.h..hPss..thl.h...poL..hp+a...sshss.hth....................s.phht..thspplpltshc..l....cs....hthth...........pttphsGhhGphsaphp.............htphhthLLthupasGlGtpsuhGhGth............	0	82	133	161
+9873	PF10041	DUF2277		Uncharacterized conserved protein (DUF2277)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5552)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	64.60	61.40	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.58	0.72	-4.02	22	232	2009-01-15 18:05:59	2007-07-31 09:12:33	4	2	229	0	100	209	12	79.60	55	87.30	CHANGED	MCRNI+sLhshEPP.....ATc-EIcAAALQaVRKlSGhscPSpANptAF-pAVt-IutsopcL.LsuL.sps......PP+sRtt.tA+	..MCRNIppLRs.hp.PP.....ATs-EIcAAALQYVRKVSGhp+PSs.ANpEAF-pAVs-VsssTp+L.LsuLss+t......PPhcR.t.tA+...............	0	31	70	87
+9874	PF10042	DUF2278		Uncharacterized conserved protein (DUF2278)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5634)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	27.50	28.80	19.10	22.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.45	0.70	-4.60	27	254	2009-01-15 18:05:59	2007-07-31 09:13:42	4	4	223	0	76	227	3	209.10	41	82.83	CHANGED	Msl...psYGVhKup.hphth-tttp..tsPHhplhlcssss...........................spaRsAlNlcSss......t.sucllYhhspph.p+Plhpp.LssLs.Gap.Lp...........................ssssthuLDYlRss.Lhsspsh+sls.hDhs...................GssNDlhchL-shlppuhtp.........................ssplYlFGph.............F......................psu.sG....lHslHMNQGss..p.......caps-NGlaQDGulllch.......sD..........pWsulFlAFtoQshhT.Ds...pGc	..............................MsL...psYGVLKGpslp.pht.....pst...toPHYpV+lpsp.ss...........................s-aRl.AINVcSps........h.sS-ll.Yhssp...sh...cp.shph.L..s..sLs.GaTclp...............................sspstsALDYlRus.....LaDspphhsLP..h-ts...................GscNDLs-hl-phlcpAhp.p.........................cuhlYsFGcp.............F.................................pPG...NG....IHDIHMNQGNs..p.......+apsDNGlWQDGulLlca......p-..............tp.W..hulFLAFpSQuasT.D-.pGp.............	0	20	34	53
+9875	PF10043	DUF2279		Predicted periplasmic lipoprotein (DUF2279)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5544)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	28.50	28.50	28.50	28.60	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.01	0.72	-3.71	20	603	2009-01-15 18:05:59	2007-07-31 09:14:20	4	1	591	0	71	238	32	86.00	69	70.70	CHANGED	usDsWsup...........D+ApHF........hsSAsLuAsusp.........tp.h.huhhhosulGhhKELaDoppuGSGaSapDLAhDhAGushGhslhpts	............A.NDuWSGQ...........DKAQHF........lASAMLSAAGNEYupH..QGhScDRSA.hFGLMFSlSLGASKELWDS.RP..EGSGWSWKDhAWDVAGAoTGYslWQh.s..........	0	14	34	52
+9876	PF10044	Ret_tiss		Retinal tissue protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4402)	Family	Rtp is a family of proteins of approximately 112 amino acids in length which is conserved from nematodes to humans. The proposed tertiary structure is of almost entirely alpha helix interrupted only by loops located at proline residues. Three sites in the protein sequence reveal two types of possible post-translation modification. A serine residue, at position 41, is a candidate for protein kinase C phosphorylation. Glycine residues at position 69 and 91 are probable sites for acetylation by covalent amide linkage of myristate via N-myristoyl transferase. Rtp is differentially expressed in the trout retina between parr and smolt developmental stages (smoltification). It is likely to be a house-keeping protein [1].	21.70	21.70	21.90	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.21	0.72	-3.45	7	126	2009-01-15 18:05:59	2007-07-31 09:14:58	4	3	87	0	79	121	0	89.70	44	69.00	CHANGED	LlShEpLDRuSP-lWPEphPGhsEFho.sts.h...pssPpahssLsc-DhshlpcLGsLosspLhtKlKpLps.AYQLGLcEA+EMTRGKaLsIhs	......................................LlShEpL..RsSP-lWPEp....h......PGls.-Fss.p.p.sshp..sssscahsc.l.c.....p.-Dl..c...hlpELusLTsssLh-Kl+sLpshAYQLGL-E............u..+EMTRGKaLsIhp.......	0	24	31	56
+9877	PF10045	DUF2280		Uncharacterized conserved protein (DUF2280)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5556)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.00	24.00	27.40	24.50	23.60	21.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.90	0.72	-4.11	15	135	2009-01-15 18:05:59	2007-07-31 09:15:31	4	3	102	0	25	104	1	99.90	48	65.70	CHANGED	MAsLss-VKuFIVQALACFDTPSpVscAVKcEFGlcloRQQsEoaDPTKtAG+sLuc+WtsLFccTRc+Fhp-sucIPIAN+AaRLRsLsRhupKAEph+NhuL	..........MAsLpppVKhFIVQuLACFDTPopVAcAV+pEFGlcloRQQVEsaDPTKsuG+sL.u+Kah-LFppTRccFppc.ltsIPIAN+AYRL+tLpRhhpcscp.+sh..h...........................	0	2	10	20
+9878	PF10046	BLOC1_2		Biogenesis of lysosome-related organelles complex-1 subunit 2 	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4559)	Family	Members of this family of proteins play a role in cellular proliferation, as well as in the biogenesis of specialized organelles of the endosomal-lysosomal system.	26.80	26.80	26.80	27.20	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.22	0.72	-3.86	17	169	2009-01-15 18:05:59	2007-07-31 09:16:01	4	4	142	0	123	176	6	95.60	35	58.97	CHANGED	hpchhsshsphlpuphptospchpLLEphNpssst+YtchpphspsLpsphcpLptp.pphpsalppIcpI-pplspLEpssptLDtasppLEsKlpsl	...........pchFschupalpuELsuosp-Yc..LLEpMNchsuh+Yh-hcslutslspslpcLsp.Ka.tpL.pPalpQIstI-cpVspLEpsshcLDsYoppLEs.KhKp.................	0	40	60	98
+9879	PF10047	DUF2281		Protein of unknown function (DUF2281)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5559)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.14	0.72	-3.68	19	250	2009-09-11 14:35:08	2007-07-31 09:17:16	4	5	143	0	89	275	17	56.90	21	71.76	CHANGED	sppplhpplppLPpclhpElLDas-FLhpKt..............h.pptsppthhhshtGt..h..pp.pshs.sslElQ+chh	.....................h..ttlhpplppL.PcphtpEVlDFl-FLhpKt.................t.t..................................................................................................	0	26	63	83
+9880	PF10048	DUF2282		Predicted integral membrane protein (DUF2282)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5572)	Family	Members of this family of hypothetical bacterial proteins and putative signal peptide proteins have no known function.	22.40	22.40	24.00	23.30	22.20	19.40	hmmbuild  --amino -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-9.04	0.72	-4.06	74	316	2009-01-15 18:05:59	2007-07-31 09:18:13	4	5	262	0	115	309	38	55.50	49	57.74	CHANGED	pEKCY......GV.uhAGpNDCuA.GsGToCAGTSpsDhQGsAWphVstGTC..........ppl............ttGoLp	..........hEKCY......GV.AhAGpNDCAs.....usuooCAGoSphDhQusAWphVPtGTCspl...............stGoh.t......................	1	22	60	95
+9881	PF10049	DUF2283		Protein of unknown function (DUF2283)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5428)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.80	20.80	20.80	21.40	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.33	0.72	-4.11	63	354	2009-01-15 18:05:59	2007-07-31 09:19:17	4	2	242	0	146	369	32	50.30	28	59.25	CHANGED	h+lpYDt-sDsLYlpl..spssht.......-ot-lss........slllDhDppGcllGIElLpAo	..............plpYD.-sDsLYlpl......psspht...........-op-lss...............slllDh......D.ppGcll.GIElhssp...............	0	47	102	126
+9882	PF10050	DUF2284		Predicted metal-binding protein (DUF2284)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5423)	Family	Members of this family of metal-binding hypothetical bacterial proteins have no known function.	25.00	25.00	28.30	27.60	22.00	21.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.38	0.71	-4.65	37	229	2009-01-15 18:05:59	2007-07-31 09:19:58	4	5	162	0	103	212	12	159.70	24	78.21	CHANGED	chthlpstclsl.pppsth+Cp..sCssYGpphsCPPtssshcEh+chlpcYcpAlLhphphsspp.tp.............................hhthppplpphhhclE+phhttGa.hAhshhsGsCp..hCp..p.......Cshpp..tt...........C+hPchsRsShEAhGl-lhphscps.sh.hphht.............pphshhuhlLl	........................h.stclhhptchhth.Cc...tCssYGpshuCP..Ph.ss.....ssc-htthlppYcpuhlhphp..h.hpst.............................t.hh.....ptp.hpphhhchEcp.h..h......t..p.u.a...shsh.hsG.sCp..hCp....c.......Cshtp..sts............CRaPccsRsSlEAhGlDltphscph.shph.hst...........phhshhuhlh....................................	0	56	88	95
+9883	PF10051	DUF2286		Uncharacterized protein conserved in archaea (DUF2286)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5399)	Family	Members of this family of hypothetical archaeal proteins have no known function.	24.00	24.00	24.30	107.50	23.40	18.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.63	0.71	-4.54	12	37	2009-01-15 18:05:59	2007-07-31 09:20:22	4	1	37	0	21	27	0	143.70	41	98.34	CHANGED	M..slVs+hccspVspc-VlcG-ls-lV+clAtchLc.EWsPpsSDFlllRDhhplphPhPL.p.ElhEcl..+paphp+scscs.lplPla.IsasspWh.tpsapsccshVVhPYlD-ptpcElhchshpshut.t............................cEEt.pc.E	...M.+llllKuEsGcVssccls-.G-lscVl+clAp-.ALc.EWN.hsSDFIIhRDs.ElclPLPL.pP-lYEtl..+pF....hht+scscA.hsclPVYhISa-NpWt.-ssapDc+laVVu.YIsD-hpcpllssAsphToppc............................pE..tc...-.p.........................	0	8	11	16
+9884	PF10052	DUF2288		Protein of unknown function (DUF2288)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5626)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	58.60	58.30	22.40	17.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.07	0.72	-4.27	36	217	2009-01-15 18:05:59	2007-07-31 09:20:50	4	1	217	\N	72	199	26	92.90	42	87.76	CHANGED	ssL+scLtt-TuplsWp-LpsaaARGsllhVsssLDLl-VAhulApDspspVppWlssGplu+sosppApcW.hpcs.phWAVVVuPWVLVQ-c	.....o.sLhs+LhuETApIsWs-Lp.FFA+GsLlhVstsLDLlpVAcAlApDDsppVspWLusGtlu+sssppAt-a.hscssp..LWAVVVuPWVLVQp....	0	18	41	59
+9885	PF10053	DUF2290		Uncharacterized conserved protein (DUF2290)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5619)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.10	34.90	24.30	23.10	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.49	0.71	-4.99	8	37	2009-01-15 18:05:59	2007-07-31 09:21:39	4	1	36	0	11	36	0	185.10	31	87.28	CHANGED	Lss-.Nhsshpp.s......ssscloasGtEcsulhht-hsYucl..YpulhcppuYshhLlDGuLlQhpYchcpspLlpHRLuYYPsPtLhs.............hps-s-lhhpDhLhh-hspctllshP....lRFDFDs..tttp...cssHPsSHlTlGsssuCRIPVsusLTPcpFlcFVlRNFYpoha+chlut.....hsstph-Fc....soIsspEpslhHls..hs	.............................................N.s..pp.s......th..lshss.tp.....pshpYpcl..YptlhcppsYshhL.hDGullQh.Ychp..p..spllpHRLuaaPuP.hlps.............aps-s-hYhpDhlhh-.....Ihpcpl....ls..hP....lRFDaDs..stht.......chtHPpSHLTlGphpsCRIPVsuPlTPphFlpFlL+pFYpothcsh.st.....hsphp...pFp.....olh..EtthhHhs..s.........................	0	4	7	9
+9886	PF10054	DUF2291		Predicted periplasmic lipoprotein (DUF2291)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5618)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.10	20.10	32.50	32.50	18.90	18.20	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.21	0.70	-5.04	21	215	2009-01-15 18:05:59	2007-07-31 09:27:20	4	2	195	4	58	151	13	196.30	36	91.75	CHANGED	sllhsAsslllLsthupcIl...h..up-ssutsus.tFsPcphusphW.sclhs.sppcAlshs-ltstlssstsuAsppYG...ht.ss..shhV+hoGsVsssc.....suthslclcGs.tpsslplQhGPslpGoulRDAsuhlpFs-F+NQI-asphupAlNspspspVlt.h.....scsslsG+plsVhGsasL..sssph...hlsPlplpl	.....................................s.h.shssllllshsGtclh......p.s.sDss.s......hs..s....s..hsPs.shusshW.scVhs...plppcAlshsEltstl..su..st..s..uAscpaG....st.sss.shsV+hoG.sVsphc.....uuhhsl.c.l-.G....t.hslplQhGPslpGTsLRD.AsshIpFs-F+NQlpasphupAlNpchtppVh..h.....ssp.shsGcsVsVlGsFsl..sssp.......lTPlpLp...	1	10	24	39
+9887	PF10055	DUF2292		Uncharacterized small protein (DUF2292)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5583)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.00	20.00	20.10	20.30	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.40	0.72	-7.45	0.72	-4.62	23	311	2009-01-15 18:05:59	2007-07-31 09:28:01	4	2	292	0	79	190	5	37.40	43	67.35	CHANGED	chlccIpchLcsl+aGSlTlslQDGpVlQI-+sEKlRL	..................l.ccIpshLpsh+....aGolpIsVpDGpVlQlE+sEKhRL........	0	27	55	67
+9888	PF10056	DUF2293		Uncharacterized conserved protein (DUF2293)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5586)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	26.40	25.40	24.90	23.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.98	0.72	-4.01	25	287	2009-01-15 18:05:59	2007-07-31 09:29:46	4	1	242	0	124	205	3	84.60	39	24.91	CHANGED	pAl+sLaPthPtpc......tcsIlpHAh.cu......utRVG+.sushs.tt.+VpLAVhAHlRHpaTcYD..pLLcsGhsRcpARptVhctspslLpcWt	.........................t.ulppLhPthPtsc......tpsIhp+Ah.cu........................pt+lut..sushs...t..tVpLAVsAHlRHhaTcYD..pLL..c.s.G.hs+csARthVhptlpshLscWR.............	0	26	68	98
+9889	PF10057	DUF2294		Uncharacterized conserved protein (DUF2294)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5609)	Family	Members of this family of hypothetical bacterial proteins have no known function.	21.40	21.40	21.60	22.00	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.25	0.71	-10.06	0.71	-4.44	23	741	2009-09-11 07:39:01	2007-07-31 09:30:33	4	4	437	0	101	280	9	110.00	38	92.03	CHANGED	Mppo.+stlEpEISculppacK-hlGRGstplKThIlcsMlllpLcGlLTssEptlspo...tcGhthlKpsRspLh-st..ppclpcllpclhGpcVhuhaoDloscTGEplhVFhL-.......pslEK	..............................hEtchschlpphcK-hhG+Gs.p.l.+osh.hcsMs.IssLpGlLTPsEhhlspT....p-Gh.hl+tsRo-.hlcps..ppphp.chlpclsGtKl..hshaoDlsspssEtl.lFhh-....cslE.........................................	0	46	70	88
+9890	PF10058	DUF2296		Predicted integral membrane metal-binding protein (DUF2296)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5415)	Family	This domain, found in various hypothetical bacterial and eukaryotic metal-binding proteins, has no known function.	21.70	21.70	21.70	21.70	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.81	0.72	-4.22	30	334	2009-01-15 18:05:59	2007-07-31 09:31:15	4	6	254	0	214	322	1	52.20	42	14.26	CHANGED	ahDRllDhLlGsss.......psRhALICppCptHNGhu...pcchp.l.papCspCsshN	....................hDRll-hLlG-ss.......psRaALI.CppCttHNGhAh...pc-hphl.ta+CshCthhN...........	0	60	110	171
+9892	PF10060	DUF2298		Uncharacterized membrane protein (DUF2298)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5427)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	24.70	24.70	25.00	24.70	23.00	24.60	hmmbuild  -o /dev/null HMM SEED	473	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.96	0.70	-5.65	18	117	2009-01-15 18:05:59	2007-07-31 09:33:29	4	9	68	0	64	119	65	412.70	21	56.82	CHANGED	lllsassahluhl...hsa.......sllls...slhlhshuhhh...hh+pc........h........t.hlts-hlFhsuFhFhlhlRsapPtl.h.....Gs..EKFMDauahsulhRusshPPpDsWFAGtpls.YYYhGaLlsulhuhLoulssphuaNLAlAshhAhsssuhaGlutslspth..............h.hhhhsshhshhh........ushhshh..h.................hthhushhhttssshsa................................................aWsuSRsl.ss.....................IsEFPhFoalhGDlHuHhlul...sFhlLsluhshshatptsppp..............................thhhlh...hulsLGhlhssNo.WDaPlah...sLshhslhhh.tt.h.h...................ph..hhs.............t.ssllslluhllhlPFhls..hpstuhtt.....hshl..............ppohh.phlhla.GhFhhhhh..uaLhsplppt............hhhhh..h.hh.......hhshslhulhhPllshuhhthhppp.................sssFhsLLlhsuhsllllsEllYlp-s.hss...sRMNTVF..KFYhplWllh	..............................................hhshhhahhs.h.....................hhhs....hh.hlh.shsh.hh.....hhptt...............................h.......ht.hh.h-..hlF.h..hhFhhhlhlRh.....hs...Psh.h............usE+.hDhuah....pulh+ushhPP.D.WauGt.ls.YYY.hGahhhuhhshlouhssthuaNLslshhhuhhhhssaulsht..lhtth................................................hhshh.h.shhh.........sh..hh..h........................................h.....h.h..h.....h.........................................hW....soRsl...s...................................IsEFPhFoalhuDhHsHhhsh......shhlh.hhshhh.th..h.hp.tttt..............................h.hhhh...hulhhGh.h.hhhNs.Wshshhh...hlh..h.h.slh.h.h.h.p..h.............................................................shhhhhhuhl.lhhPFhht..h.s.s..tt...............l.thh......................pto.h.phlhla.Ghhlhhhh.......hh.hhtthht..........................................................................hh......h..........h.h.h.hh.hhh....hhhhh......hhhhh..................................................t.hh.hl..hhhhuhhlhhhsEhhal.p-...................RhNTlFKhhhpsWhlh...........................	0	23	51	54
+9893	PF10061	DUF2299		Uncharacterized conserved protein (DUF2299)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5440)	Family	Members of this family of hypothetical bacterial proteins have no known function.	22.10	22.10	22.20	22.40	19.30	21.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.67	0.71	-4.73	13	64	2009-01-15 18:05:59	2007-07-31 09:35:12	4	1	45	4	34	53	58	135.50	29	87.04	CHANGED	cItsWhpELGhhlp+...sssusthFHlssoPPt.sssslsllRssscosaYlluhulslcspH.phl.thphccRpchltplph-Ll+h.sV-FhhhPPsp-.PpsIQlu+.latDG..LTKNchlssltpV+NuulhVl.hlp	..............................ltsWlpEhGhhspc...sssupthFHhssssPt..uGsslsVl+PpscschYlluhultlc.pH.ptl.thphc-Rt+...hltplph-LLch.sV-F.hhh....P..s.sp-.PpsIpVu+.la.tDG..LT...pNchlsslhpV+Nuslhll.hh............................	0	8	19	29
+9894	PF10062	DUF2300		Predicted secreted protein (DUF2300)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5445)	Family	This domain, found in various bacterial hypothetical and putative signal peptide proteins, has no known function.	25.00	25.00	26.00	35.30	24.30	22.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.88	0.71	-4.43	13	657	2009-01-15 18:05:59	2007-07-31 09:35:38	4	4	320	0	34	314	12	129.20	50	47.26	CHANGED	+uspssp......hhsspAstuhthDthLsp.....oluhahpPhthshsshshsphW.t+psPtWhtcLsshssappssshslsclhpshPhpDptRctlh........stslholtsRl.........slspphhahuFuuaPs	........GspspE.......hssQAGpu.phDphLsh.....ShuhahAPpp.phth.shuphW...t+....p.hPtWht.Lps.ps.s.pssVhulhc..lushPhps+..tQchLh...................Itsh.hLtsRl.........D.ppEhhphuFsGa....................................	0	5	13	24
+9895	PF10063	DUF2301		Uncharacterized integral membrane protein (DUF2301)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5413)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.00	25.00	31.00	29.50	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.73	0.71	-3.96	38	200	2009-01-15 18:05:59	2007-07-31 09:36:44	4	1	188	0	59	175	0	123.50	38	62.52	CHANGED	luLphIHIYl+sl+phLQhhWhlGsluh....hhh.h....t.h...lhspPh....hLulGshFsuLsGluFKEaFCFp+hEshhlshLlPlhlLupLhGlhshththuLlu..ulLhlllAlRKathPltsDIGDKSlFpa	................hshsslHIYl+sh+hllQhhhhlGllst........................lhs.hPh....LulGshFhsLsGlsFKEhFCFphhthph.shllshLhLualhshh.htthhullu.....ulLhllhAlpKaphPl+hDIGDKohaph.........	1	9	32	51
+9897	PF10065	DUF2303		Uncharacterized conserved protein (DUF2303)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5532)	Family	Members of this family of hypothetical bacterial proteins have no known function.	21.90	21.90	22.10	22.10	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.51	0.70	-5.53	14	390	2009-01-15 18:05:59	2007-07-31 09:38:46	4	2	323	0	29	229	15	251.50	51	98.85	CHANGED	M......s..coAlptlttshhsusphpp...uh..shl..hlP-...uh+lpsLEpahs......p.sRh+GshpspshsuFlpYspcptp..-ssphF..Ist-....shsssulhshtsts......s...........sGas-apAshshptTstapshhshsGcthsQtchu-alED.tsslls........hsssu.......................uchlplspshpAs+phshcuusptpsspspFshpcss.psscupp...hphPstFthphsPapshsphplphRlphhh..tsup.slhhcllp.-tl.EphspEhtshlpcthpst........lhlGohp	.....................................................p.D..usAlppIp.shloAtsssp.lsthts.ssl..sLP-....sacl..c..sL..E..+Fth......sRFRFRGshoTsSI-DFs+YS...KchAs........Eu.......oR...CF..IDAD..........sMcAsoVlNlGT.l.-.p.................PG...HADNsAoLcLK..+TAPFpALL.s.lNGc+.sQKsLAEWlEDWADaLlu...............aDus...................................G-slphocAsuAVRKITI-AspouDaE-sDFSGKRSlMESVEAKoKD..lMPsuFcF+ClPFEGLc.ER.s..FcLRLSllT....GDcPVLVLRIIQLEAVp.E-hAsEFRDLLlEKFc-scl.....ETFIGTFo............................	0	7	14	21
+9898	PF10066	DUF2304		Uncharacterized conserved protein (DUF2304)	COGs, Finn RD, Sammut SJ	anon	COGs (COG2456)	Family	Members of this family of hypothetical archaeal proteins have no known function.	23.00	23.00	23.00	25.20	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.43	0.71	-4.23	15	588	2009-09-10 17:25:32	2007-07-31 09:39:02	4	3	561	0	136	408	84	113.90	23	92.15	CHANGED	Mhh.lQlIuIllhlhsllhlhhph+csplshssslhWlhhalslllhslFP.plutpIAcllGlGRGlDsLhhluIhlhahLla+LYl+l-+LER-ITcLV+EIAIc..-t.p.hp+cc	................hphl.h.l.lhu.l.h...h.hhh.llpt.l+.+.sphphchulhWllhu...lshllhulaP.plhshlAphlGltps..sshlhhhslhhlhhh.hhphohplSchc..pclppLsQcl.Alh....pt.........pt...............	0	45	79	111
+9899	PF10067	DUF2306		Predicted membrane protein (DUF2306)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5395)	Family	Members of this family of hypothetical bacterial proteins have no known function.	29.10	29.10	29.20	29.70	28.90	29.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.51	0.72	-3.90	47	499	2012-10-01 23:59:14	2007-07-31 09:40:11	4	1	398	0	212	456	145	104.70	23	44.00	CHANGED	hptKssp....hHRhlG+lalshhl.lsAlouhaltth...thhu.....asshalLuhhhlhshhhulhss++tp.......lttH+thMltsYhhulsssshhsh.l..........ssRhhhsllhs	............Rp+thphHRhhG+lal.shhl..lsulou.h..h.lsh.h..s...hs.h.hs.....hhsh.tlL.u...lhhlhssh.hAlhsh+..ptp...............ltpHRpWMlRsahhshsss..shphh..h....................h.hhh............................................	0	79	141	186
+9901	PF10069	DICT	DUF2308;	Sensory domain found in DIguanylate Cyclases & Two-component systems	Anantharaman V	anon	Manual	Domain	DICT is a sensory domain found associated with GGDEF, EAL, HD-GYP STAS, and two component systems [1]. It assumes an alpha+beta fold  with a 4-stranded beta-sheet and might have a role in light response [1].	25.00	25.00	36.90	36.30	23.80	23.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.48	0.71	-4.61	93	183	2009-01-15 18:05:59	2007-07-31 09:43:40	4	11	104	0	87	191	1	125.80	24	28.34	CHANGED	hs.spushppLhpt.h.t...s..p.thahKsoLhALs+ulEDpllp......sp.pshlhuuFQptchappEs...cR.YpclAppup.plalhus................................................s-ssh......sssphhpshh....lsssDsLspEWaLllluss.....asuhllspEh	....................................t..........p.thh.KspLhulS+slEDpslp......ss.ps..llhusFQctphappcs...cRYpclAppss.plalhus................................................s-ssh......sspthpslt.....hsssDs.LspEWallllusp......asuhLlspE..............	0	18	66	86
+9902	PF10070	DUF2309		Uncharacterized protein conserved in bacteria (DUF2309)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3002)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.30	26.20	23.50	23.20	hmmbuild  -o /dev/null HMM SEED	788	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.47	0.70	-13.30	0.70	-6.43	67	634	2009-01-15 18:05:59	2007-07-31 09:44:26	4	4	569	0	133	484	108	793.90	40	94.76	CHANGED	hlcpAschIsPhWPLcsalAsNPahGhpcpsFtpsusphtpltGschhhspshappthtpGcIspssLptsltt........................................................................................ttshshshsphhtthtp.................................................tt..ttl........slu-hhsshp......u....hshsshlscplspasuuaaDpGQuhWp...Pt+cpGhYsAW+phsppDhshtht...t.tthtphltphPpssppulspslppL..slspsthpsYhcphLhsLsGWAuhhpapphps...th.sppp.tslh-hLAlRLsh-hsLh............................................................hht..htthht...............................thtspttpshhs.............ppshthstlhpcAhEtuapcpLhpsl..........................t.....ssssssst..............+P..th.QusFCIDVRSEshRRtLEshsPt....hcThGhAGFFGlPltapshussstcsphPsLLsPphtl...........t.s...ttpthpppp...chptphpptapphKpsslouFshVEssG.hauhcLltcoLts.............................ptssshh.php....t..................................................................................uhohp-plshAtshL+uMuLT...psFA.LVllsGHGSposNNPasuuL-CGACGGpsGtsNARllAtlLNcspVRpuLtpc.GIsIP-DThFlAAlHsTTTDclphastct.lsts...tpsshcplcshLspAuphsptERutpLs...tssp...........p.hpplpcRupDWuEsRPEWGLAsNAuFIluPRphTpuhsLcGRuFLHsYDWpp.Dp..cuslLEhIloAPhlVupWINLQYYuSTVsschaGSGsKlhHNVs.GslGVhpGNuGDLRsGLPhQSVcc.spphhHcPlRLhVlI-APt-tlpcllpcp.............ssl+pLh-NtWL	...............................................l.lppAp+lIsPl.PlstFsApNPa.GhEspsFcpsAphL+cltsscla.stuhhcpthtpGcIspsslpptlsphh................................................................................................................................hph.sptthphhhpshtp.............................................................................tshtt.sh..............shu-hl.spp.u.........pshs-.lscphh+WsthYhDpttusWs..hP..pR..-..p.uhYpAWhclspa...Dhuhsht..........+phlpsLPp.c..sp.slpps...Lspl..uIs.p.pphpsYlcupLLuLsGWAGhhhaRupQt.............pp-.thLpDaLAIRLshE.hLl..............................................................................tstht..hhtps.p...............................................................................................h......phssschpshhp............hhtphspthhcpLWlpAaEhsapppLhppl........................................tss...p.p..s.psss......ps...psQhAFCIDVRSEsFRRHLEshuP.....hETlGhAGFFGLPIphpslspphp+spLPVhl.sPsapl........................cphssc...phphh.pppp....pshpshhh.s.a.+..th..KpsshsohhLsEhoGsh.hulphlspolhP.............................cpsts..lp.phppphhpcs..p.sphplp...........p......................................................................................slGhT.pEplshAtpsL+hMuLT......csFAPlVVLsGHuSpSpNNPatAuL-CGACGGtoGuhNA+lLAhlsNcssVRpuLt.pp.GlhIP-cTlFhAA.HpToTDplphh.l.sc...Lsst....ttcuh-pLpshhstsuppAspERhspLs.htptt............pssp-spRhApDWSElRPEWGLApNAuFIIGpRpl.....TcshcL-GRsFLHsYDWcp.Dp-G..plLssIlouPslVApWINLQYYASTVsP+hYGSGNKsspsVs.uulGVhpGNuuDLhhGLsW.QSVhs.spphhHpPlRLhVVIpAPpthlpcllspp.............tphpchVpNpWl.....................................	0	43	87	115
+9903	PF10071	DUF2310		Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5595)	Family	Members of this family of proteobacterial zinc ribbon proteins are thought to bind to nucleic acids, however their exact function has not as yet been defined.	25.00	25.00	31.80	31.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.83	0.70	-5.42	23	268	2009-01-15 18:05:59	2007-07-31 09:45:21	4	2	257	0	54	193	9	249.40	52	99.43	CHANGED	MalsElpFc..sapssslsssp+sINpll-thRYNGQILGREaPlshspsp....FtsRllCPEpsSLtscaNSspVppALppLscsGllhsphcllGcDlNS-tos....cpppPoWQlLYTTalcoCSP.....L+sGDsltPIPLY+hs.sphsu..pcsllKWQp-WQACDpLQMsGus..hEphALcEIu-ssScLh++GhcLspcIEthTpIPTYYYLYR.VGGpSLtsEppRpCPpCGu.-WpLspPLaDlFcFKCDcCRLVSNLS..W-ap	............MYllELpF-..sassTolsus-+AINsLhDshRYNGQllGREFPlshu-s......FhVRllCPEp-SLaPcapSthVptslpcLs-suLltPph+llGpDlNSEpsA....Ep.-pPSWQlLYTTYlcoC..SP.....L+SG-sLhPIPLY+ps..sshsuD.acslIKWQp-WQACDpLQMsGus..sEpsALcEIs-scSsLF++GaDLptRIEhlTplPTYYYlYR.VGG....pSLspEpsR.CPpCGu.-WhLc-PL.....aDlFaF+C-sCRlVSNlSW-a.......	0	10	20	38
+9905	PF10073	DUF2312		Uncharacterized protein conserved in bacteria (DUF2312)	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG3750)	Family	Members of this family of hypothetical bacterial proteins have no known function. Structural modelling suggests this domain may bind nucleic acids [1].	21.70	21.70	21.90	22.40	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.28	0.72	-4.62	51	455	2009-01-15 18:05:59	2007-07-31 09:47:06	4	3	340	0	158	352	153	73.20	50	78.91	CHANGED	lAu-pLRpaIERIERLEEEKKslu--IK-VYAEAKupGaDsKllRpllpL....RKpDps-+pEpEslL-lYhpALGM	...............As-pLRsaIERIERLEEEKKs........lu-DIK-VauEAKupGFDsKllRpIl+L....RKp-...ps...-htEpEul..L-lYhpALGM..................	0	44	91	109
+9906	PF10074	DUF2285		Uncharacterized conserved protein (DUF2285)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5419)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.00	23.00	23.30	23.30	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.46	0.72	-3.70	33	292	2009-01-15 18:05:59	2007-07-31 09:47:52	4	2	153	0	155	286	28	100.70	27	57.06	CHANGED	lhlPLcsshts....................RhcAhtRhhctLp.u+sssPssph..hsstp+tRhhphLpAlDuchsGAShR-IAtsLFGs..splstc..Wps..uulRsplpRLV+cGpuLhcGGYR+LLp	.................................................................................................t......ss.stt.....hss.pct+hlthL+sLDu....ptsGA.oaR-lA.p.slaGt..csspts...ats..sthRsph..cph..lc+upthhcuGYRpLLp.........	0	23	94	128
+9907	PF10075	PCI_Csn8		COP9 signalosome, subunit CSN8	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4414)	Family	This PCI_Csn8 domain is conserved from plants to humans. It is a signature protein motif found in components of CSN (COP9 signalosome).  It functions as a structural scaffold for subunit-subunit interactions within the complex and is a key regulator of photomorphogenic development [1].	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.52	0.71	-4.42	48	621	2012-10-04 14:01:12	2007-07-31 09:48:56	4	7	256	1	376	1244	4	138.70	20	59.51	CHANGED	hhptphhu.hLlthLspsch.ssFchthchlPsshpps...................stplpplhpLtphLhpssYspha....phlcps....sp..phpshlssh..t-plRcclsphltpuY.....psIshpthuphLshs..sc.......phppasppp.GWpl..-........ssshhl.h.sc.ptpsps	............................................................hh....phhu.hLlhhL.h...p....h.ssFphh..hphl...s....t.....p..h..h.pt.......................................................................p..l...pplh.tL.tphL.ps.pas...pha....................p.h...css....................p.............sht..hl..s.sh.....p-sl...RcclsphlspuY............p.p.I.shsthsphLshs....sp................ph.ppa....s....pc...p...GWph..s...........ss.s.h.h..h......t.p..................................................	1	132	192	290
+9908	PF10076	DUF2313		Uncharacterized protein conserved in bacteria (DUF2313)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3778)	Family	Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins.	27.20	27.20	27.60	27.60	27.00	26.50	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.80	0.71	-4.88	60	660	2009-01-15 18:05:59	2007-07-31 09:49:48	4	5	514	0	114	541	6	159.10	22	80.70	CHANGED	ptLhphLPssht.sc.....hptlhpu.usplsplptpupsllpphhPpous..hLscWEchhGlss....ssst.olppRRptlhsKhptpGuhohthhtplApsh.Gh...slpIpphp....................hpahapVphs..........shsssscslps......lcshlcch+PAH....hsYs	.....................t..LhthLPsh.t.s.t.............hpth.hpuhu.phsplpppspplhpph.spTss....hlscWEchhGLss......sssp.olppRpptlhuKh....p..t.tGsh........ohtahhphhpsh.Gh...shplpphp........................................hpahhplphs............................shssss.sslpt..........lcshlpchpPuH.hhhh.Y.................................................................	0	38	77	97
+9909	PF10077	DUF2314		Uncharacterized protein conserved in bacteria (DUF2314)	COGs, Finn RD, Sammut SJ	anon	COGs (COG3779)	Family	This domain is found in various bacterial hypothetical proteins, as well as putative ankyrin repeat proteins. The exact function of the domains comprising this family has not, as yet, been determined.	21.10	21.10	21.50	21.10	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.79	0.71	-4.10	10	385	2009-09-11 08:32:28	2007-07-31 09:50:18	4	9	337	0	61	293	6	114.60	27	42.17	CHANGED	DscMttAhs+ARpTF+aFWRELuW-pRRIlsuLDhAh.VKVsF.pD.t.....susssEaMWlsclsF..DGctlhGsLsN-PcploNlcp.GDplshsh--IuDWhalssG+saGuFTlsAMRupM.SccERscHDpAWGlDF	........................................................t......hh.pAppphthF..plh..pp.....h..hhh...VKlsa....-....................ptspsEHhWlp...hph..s.st.hhhGlLs.N-P...hhlpslc..Gpphplsh-.cIoDWh.hh.t.sst...............................................................................................	1	19	36	43
+9910	PF10078	DUF2316		Uncharacterized protein conserved in bacteria (DUF2316)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4367)	Domain	Members of this family of hypothetical bacterial proteins have no known function.	26.00	26.00	35.70	32.70	25.70	25.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.75	0.72	-3.99	7	273	2012-10-04 14:01:12	2007-07-31 09:50:44	4	2	268	0	23	100	1	91.20	54	95.69	CHANGED	MSLshtph+sT+pELptNFpLssLolpplAp-Lpho.sclEtlLpLc...........pplpDsWhLRsYL.ctlpppGppPhPaotLsG-....tpaWFLs	....MSLNKEQRRITsEELQAHFEtSTLSlphIAccLNlToE-VEKlLuMpsP.GlFuppLQRF.IHLVWDVRDlINDNIKtNGQTPcPYTYLKGEK...EDYWFLc.............	0	9	14	19
+9911	PF10079	DUF2317		Uncharacterized protein conserved in bacteria (DUF2317)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4365)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.20	24.20	25.10	24.70	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.09	0.70	-12.61	0.70	-5.90	54	546	2009-01-15 18:05:59	2007-07-31 09:51:26	4	3	532	0	133	404	329	519.30	36	99.20	CHANGED	Mphcplsh.pp...sphhtDYhspppp....lpsFaph..h.p.psapcplsphppph...t...RpsLschLppphpphss.upts.psI-tLtp.pohsVlTGQQhGLFTGPLYolYKllSsIsLA+chcpph.shshVPVFWlAuEDHDa-ElNahhh.t.tt...+Khphp....t..cs.psussphsspslpphlcphhppl....spopasptlhphhpcs...........Y.tpssohs-uFttlhpcLFtchGLlllDusDspL+plttshhpctlpppsshtpslpppppplc.phGhs..lQspscplNLFahp..c.stRptlp..tcsspF..hlpsschpaoccELlchlcscPERFSPNVlhRPlhQEhlLPslAaIGGPGEIuYWupL+psFcthslphPhllPRhohsllpp+hp+hlp+h..........plshpclhhpth.......phhpcph.t.tppsslptshppt+p.......plpptappLtshstphDsohtshlptsptphhctl-tLEc+hh+utcR+pcphlpphpclpspLhPpsu.QERhhNhh.ah..scaG.pllsplhp.hpshtsp.phhlpl	.................................................Mchp.lslspp...sphlschhsuc........lpuhFpY.thhpp.puFccRhpc.sstc.......ctsLssslpcYhsc.....L.......p.h...o...ppp.tNIptL.sssohVVluGQQAGLFsGPLYThHKIhSlIpLuK-lp-ph.ptpVVPVFWIAGEDHDaDElNHTalhs.pptpl+Klpacshp....cs..osSchh.s..ptc.h+..phlcphFtphtE....TsaTpsllphhcch...........lcp.....hsoasDhFttLlpchF.....tsa.GllhlDuph.tLR+h..EsPhFKcllp+pptlpcuhcssQpphp.p.GhpshIpscss.lpLFhcp............-..s.RpLlp..h-stpF..hlpcsctsaoc-EllphhEppP.EpFSNNVVTRPLMpEalFsTlAFlGGPuEItYWuELKsVFchhslcMPhVhPRlplThlpc+lp+hLpch..........slshpclhh.s.s.l.......-t.+ppalppptspph.pchcthhc.......phpclapsLhp.ltt.psslp........hlpKNpphhhpQh-hL.++hhhslE+cp-lphcpFccIppsL+PhGu.QERlWNsh.hL..Nca.GhDhhc..h...PhsashpHhllp........................................	0	48	94	121
+9912	PF10080	DUF2318		Predicted membrane protein (DUF2318)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4393)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	25.40	36.20	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.04	0.72	-10.75	0.72	-4.25	36	409	2009-01-15 18:05:59	2007-07-31 09:51:54	4	3	396	0	77	306	8	104.00	46	25.67	CHANGED	plpDGKlH+ata.scsG+plRFFllpcsc...sphsssFDACplC..ucpGYh.pcGspllChsCss+hhlsoIG..psGGCNPlPl...saphcssplhIstssLpsGspaF	.......................lcDsKLHRFsY...lus-G....K....slRFFlIp+hs..tsuhsssFDAC.lC..GDtGYh.pcssplIChsCsV+lhlsolG..psG..GCNPIPl.....pachc.spcIsIstpsLtuGssaF.....	0	28	54	70
+9913	PF10081	Abhydrolase_9	DUF2319;	Alpha/beta-hydrolase family	COGs, Finn RD, Sammut SJ, Eberhardt R	anon	COGs (COG4425)	Family	This is a family of alpha/beta hydrolases which may function as lipases. This domain is the catalytic domain and includes the catalytic triad and the GXSXG sequence motif which is a characteristic of these enzymes [1].	26.00	26.00	51.00	35.40	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.74	0.70	-5.71	25	395	2009-01-15 18:05:59	2007-07-31 09:52:33	4	5	288	0	111	304	47	266.90	43	52.72	CHANGED	IRVYVGLsu.u-os-pRAcLAlcELcRsGAF-RpVLVlsssTGTGWl-PsuhcslEahasGDsAoVuhQYSYLsShLohLs-p-tuhcuAcALF-AVasaWppLPpspRP+LalaG.SLGAhuopsua..shhc.ltcs.hcGALWsGPPh.SphWpplsspRcsGSPthLPhacsGphVRF..ssp.sslst......sss.W.GthRllaLQauSDPlVaasscllaRcPDWlpEPtGs..........DVospl+WhPlVThlQlusDhssusssPsGHGHsYs.pcalDuWsAlssP.....pGWospctpRL+	...................IRlYAGLsu.........ucsh........pupAchsltELtRTGuacRpVllltssTGoGWlsthsssulEYhhpGDsAhluhQYSaLsShluFLsD+-ssppuucALFpsVhphhp.pLP.p.pRPKLhlhG.SLGSaGGpuuF......sslsshh.up............sDGAlasGsPh.sslWpplptpRc.GSPphlPlhssGcs.VRF..hsps...p.clpp...........s..sPW.sps..RllYlQHsSDPlsWWoPchlapcP.DWh+.E..t..G................DV.PphpWhPhVTFhQVo.ADMs....hAs..ssP...sGH....GHsYt.sphhshWAAVhs......ss.T..............................	0	26	81	99
+9914	PF10082	DUF2320		Uncharacterized protein conserved in bacteria (DUF2320)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5338)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.78	0.70	-5.74	39	519	2012-10-03 17:14:37	2007-07-31 09:53:37	4	6	416	0	193	493	51	322.80	18	73.62	CHANGED	cP.atshG.hhGuFhlpPulphussassNhhp.ssstpusshhplssclphpS-WsRHtlshchpushstatssp.................s..spsshsspssuRlDlscpsplshpsphphtpEspsussshts.s..ptP..l...hpshuushulppchschplsssushp+psYpssph.sus.shsspDRshsphshssRsuYclpPuhpsFsEsphspRhYD...phDpsG......hpRDSsuhtspsGsph-hophlpG-htlGYhp+sacDsphpsloGhshsAsltWpPpphTolphssspplp-o.sssssuuslppshslplcHphpppLsspuphsaspp-Y.psts.....RpDchh.sspsuhsYtl.sRhltlpsplcacppsSsh....sstsastsslhlulplph	............................................................................................................................................................t.............sh.lhPtlp.shthssNh....t....t.................s......p..........s.............t......p......ss.h...h...........thpstlthhsc.h.t.p...p.ph.p.lshph.phtpahssp..........................................p..s...sshth.phphp.h.....-h.s.p.p.p.p.l.sh.phphthtpp..stsps....................s....h.h.......s...................p..................psh..s..ht.hsht.p.p...s...h.h........p.h.p.hshs...hpc...hYts.......sp.....................................p......p.......p........shs..hththphhaph..sth.p..hhph.hsp..p.ac......s..s.............p+s..s...pth...hhhhG..hp.h.p..h.s..tt..hpu..phthG..a.pp....sa.c....s....s.....p....h........ts.h.............s.......uhs.hsstl..pWt..s.....hp.h.oshphhsppth...........pss.....s....s...............s............s..............sh...ht.....pthslsh..s+p....h.p...s.plshpht.....hshtp.csa..psss........................ppDpph..shshs..hsYth..pRhlsl.....phth.pappp.sSsh......sshsappshhhlshp...h...............................................................................................................	0	61	127	157
+9915	PF10083	DUF2321		Uncharacterized protein conserved in bacteria (DUF2321)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4306)	Family	Members of this family of hypothetical bacterial proteins have no known function.	22.90	22.90	23.40	25.80	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.02	0.71	-4.73	5	34	2009-01-15 18:05:59	2007-07-31 09:54:32	4	3	30	0	8	25	0	131.90	41	91.49	CHANGED	MGTYhsAQIChNGHphToussps.ELhpsFCs+CGutTIspCPcCsoPIRGcYYV-GVlulGp-Y-...sPoYC+NCGKsFPWTccuLEAAsELlE-s-sLSsDE+EpFpssLsDLllE..TP+TclussRFKKlluKhuououuulRDIlVDVASEolKKuI	............MshYchAplC.NGH.hssshsps.chhpsFCspsGttTIhpCPpCsssItGc....haV-GVhsh.u..tsap...sPoaCpsCGp.aPWscptltus.pllc.t.tpLss-EhpphppslscLhh-..s.P+TplAsh+aK+hhsKhtsssssuh+-IlVDVhSEssKKtl................	0	4	8	8
+9916	PF10084	DUF2322		Uncharacterized protein conserved in bacteria (DUF2322)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4390)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.70	20.70	20.70	23.00	20.30	16.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.29	0.72	-4.28	17	258	2009-01-15 18:05:59	2007-07-31 09:54:53	4	2	251	0	58	181	35	98.30	50	92.36	CHANGED	Fp-hLpsLPul-HLuulslhsupGplltpI.stsGphGSLpVYpALAppasu.lstsAApcGLElFAEHotDA+tpPGKHPNIDhLhpllpps.s.hplp.l	..................FpD.LApLPuIDHLuulclhDus.Gp.lVt.pI.shsGKhGSLplYptLA..ppFsu.LstpAAppGLthFA.EH.ssDA+spPGKHPNIDhLhpllpps.s.Lplcs.h...................	0	11	33	47
+9918	PF10086	DUF2324		Putative membrane peptidase family (DUF2324)	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4377)	Family	This domain, found in various hypothetical bacterial proteins, has no known function. This family appears to be related to the prenyl protease 2 family Pfam:PF02517, suggesting this family may be peptidases.	23.50	23.50	23.50	23.60	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.27	0.70	-5.15	28	607	2012-10-01 21:07:14	2007-07-31 09:56:08	4	2	500	0	78	421	23	198.90	38	86.09	CHANGED	lhhhlPlh..lhhah+..+....+htlsh+shhlGulsFhlhuh...lL.......Etslphhllp.stssthh...ppPhlaslYuuLsAGlFEEsGRaluh+aLh++ppthss................uluaGlGHGGlE.AlLlGslshlshlhht..hhspGphph.h........tthhttl.t.ltshsshphhLushERlhAlslpluLSllVhhul+..p+.+hh....alhhAIllHAlhDh.......sAlhQsth..hsthhssEsll	...........................................l...llshl......hhah+...K......+hplshts.hhlGslsFhl..sp....lL..............Ep.lHhhllpsptssshh...ppPhla.h...lYG.hhhAulFEEsuRh.lhF+aL.K+hp.tps........................................ulAYGlGHGGlE.hlhl.G.hhohls....hhlhh..sslpsts.p.h...................h.pth....chl.ph...sshphhLhuhERIhAlshQlhLolhV.htAV+...pK....Khh.......aLlhAh.hlHAhhDhh......suLhQsth....lss.hlsEsh..........................	0	16	34	51
+9919	PF10087	DUF2325		Uncharacterized protein conserved in bacteria (DUF2325)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4378)	Family	Members of this family of hypothetical bacterial proteins have no known function.	24.20	24.20	24.20	24.60	24.00	24.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-9.99	0.72	-4.16	68	671	2009-01-15 18:05:59	2007-07-31 09:57:41	4	4	610	0	191	488	34	92.50	23	49.82	CHANGED	slLllGG..cphsphcphlcc...hGsphhhH....pts.pcppt.lsspl.tsDhVllhTshluHsshppl+ctu++psh..shlhs+.puhs.sltptLpphts	................................sllllGu..cphsph+pllcc.....hGschhha......ptshsppp..lsspl.t.DhllhhTshluHsshppl+ptAK+psl..sllhs..+.pShs.sltptlpph.t.......................	0	70	142	167
+9920	PF10088	DUF2326		Uncharacterized protein conserved in bacteria (DUF2326)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5293)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	26.80	26.80	27.10	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.92	0.71	-4.55	36	203	2009-01-15 18:05:59	2007-07-31 09:58:16	4	2	190	0	45	195	8	132.60	23	26.30	CHANGED	plscplY..spsu.hlshpssppup...aphph.h.......ssstSpGpsptclhC..FDlulhh.stpcp.pt.cFLlHDu.la-slDs+phtphlpllpc.hp..hshQallTl.p-cLst.........phspcphll....lcL..s.spss+LFthph	.......................................t.h.pplh...ptts...hphp..sp.p.s.........ap...hph.h.......ssstupGhpphclhs..FDlslhths.tpp.pt.tFLlHDu.lh-slDscphtshlplh.pc.tp........hs...hQhIlol.pDclsp.t.............thp.pp.hl..............lcL.....sp.pspLFthp....................................................	0	15	36	40
+9922	PF10090	DUF2328		Uncharacterized protein conserved in bacteria (DUF2328)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5385)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.86	0.71	-5.09	59	265	2012-10-11 19:05:54	2007-07-31 09:59:00	4	1	263	0	96	302	75	177.00	35	84.94	CHANGED	VGAIsNGLELLs-sss....ptt..phsLlpcSupsAsARl+FhRlAFGAAGs.spplshs-spslhpshhpss.+.....hplsWpssss.hs+stV....+llLNhlllstsAlP+GGpl.pl......spsssthplpupGp+lplcsslhphLsGs...st.pslsupsVQhhhhhhlAppsGtplshphsssplhlss	......................................................VGAIsNGLE.LL--sus....sppt................AhsLI+pSAcs....A.o..ARLp....FsR.lAFGAAGo.....hG.....sp..ID....tu..-Ap....s.lspsah..p...s...p...+......splsWp..sscs....h.l....sKscV...........KLL...LNhlLlupsAlP.RG.GslsVt....h.s.sssss......p..ahlsupGphh..R...ls..schhchlsGs.....p..psl.cA.+sVQsaYs..hLLAccsG.hplslptss-plshs......................................................................	3	25	57	70
+9923	PF10091	Glycoamylase	DUF2329;	Putative glucoamylase	COGs, Finn RD, Sammut SJ	anon	COGs (COG5368)	Family	The structure of UniProt:Q5LIB7 has an alpha/alpha toroid fold and is similar structurally to a number of glucoamylases. Most of these structural homologues are glucoamylases, involved in breaking down complex sugars (e.g. starch). The biologically relevant state is likely to be monomeric. The putative active site is located at the centre of the toroid with a well defined large cavity.	20.90	20.90	24.20	23.60	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.59	0.70	-5.29	79	731	2012-10-03 02:33:51	2007-07-31 10:00:16	4	22	543	4	234	693	90	215.20	30	13.28	CHANGED	sah.hhsuEu+ls.hlAl......spucl.pptW.hthG...Rshsshstp..sLhoas.......GshFpahhshLhhc.hs.........ss.h.pss+tssthQhpY....utp.......huh.s.WGlSpSshss.shth.............YpAaGsP.hsh...........c-tVluPaAshhul.hs.PctuhtsLcpLh...t.shhG.......cYGFa-Ahsh.T.tt............t..shlscsahAhcQGhsllhlpNh.psshhhchFtssP	.......................................................................................................hhshhhsEuhls.hlAl..........spssl.pptW..h.....phG.....cth....ss.h..stp...tsLho.hu..................Gs.hFpahhshLhhc.hs...............ss..h.pss+tsshtQhpY....ut.p.......huh.s.WGlotSshss.s.t................................Yp.ua.Gs.Pths................cssVIuPaAulhuh.as.PptultslcpLt...t..shhG..........pYGFa-AhshT.............................................shlspsahAhcQGhhllhlpNh.psuhhhchFpssP...................	0	76	157	192
+9924	PF10092	DUF2330		Uncharacterized protein conserved in bacteria (DUF2330)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4402)	Family	Members of this family of hypothetical bacterial proteins have no known function.	18.70	18.70	21.40	19.40	17.20	17.20	hmmbuild  -o /dev/null --hand HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.13	0.70	-5.59	26	145	2009-01-15 18:05:59	2007-07-31 10:00:36	4	6	120	0	43	106	19	275.80	34	66.64	CHANGED	ssutAhCGhh...VusuDsplhssup.lllh+DG....pcTslsMp.sYpGc..s-cFAhVVPVPsl...spVplustclF-+l-phoAPRlschacp-sC............tt.t...sh..sssssuu.ussshG............lsV.schpVGtYElllLoup-usGLcsWLcpNGYplPsuApslLpPYlcpGhcFhssKlsssp.........suhspLcPLph+YcSschslPlRLuhlsA.......ssp...-lhlalLusp.RhpssNYppVtl..Nh.h.thhpp..p.h..Yttlhshsht...ssspAshTEYAhssussDPssh...shs.ptLtpLusssls..t.....................................................................................................................................hstpsaLTRLas+h.sspphsEDhhFp	..................................................................................shtshCGhh....Vsttssphh.stp.sllth.DG.......sppslsMp.shpu-......scs.hAh.VVPsPss...spVpsu-..t...phFscLDshoAPhl.c.h.c..s.p...........................t..sss.suustpssu.s..........spVhsphplGsh-sshLous-.sG....LpsW....L.s....c....NG.....Y..t.....l.........sussshLcPYl+pGhtFhsh+.lsssc.......................hhsssLcPlphsa.c..Ss+hhhPhRLuhhst.......psp.clhlahLoc+.R.phsshcssp..........................................................................................................................................................................................................................................................................................................................................................................	0	19	35	42
+9925	PF10093	DUF2331		Uncharacterized protein conserved in bacteria (DUF2331)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4394)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	82.20	80.90	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.27	0.70	-5.67	50	370	2009-01-15 18:05:59	2007-07-31 10:01:19	4	2	355	0	113	360	39	352.20	41	96.25	CHANGED	WDIFCpVVDNaGDIGVsWRLA+QLupEaGh.......pVRLWVDDLsuFs+lsPplcsshstQhhsGVplppWsssh..........shssuDVVIEAFAC-LPssalsuM..............stpspsPlWlNLEYLSAEsWV-sCHuLPSPpss.s...LpKaFFFPGFostTGGLL+...EssLhscRpuFpsssss+tshhppL.................G.....l.t.t....ssspllSLFuYEssuLsuLLctap...psspPlpLLVPpGRuhssl..t.....thhs...tshtsGsthp+GsLslplLPFssQpsYD+LLWuCDlNhVRGEDSFVRAQWAu+PFlWHIYPQ--DAHlsKL-AFLshYs.tslsstsssulpshapAWNsssssss.........Wtshtsths.....tlpp....+AppWstphhspsDLAspLlpFsps	....................................hDIFCpVlDNaGDIGVsWRLARpLsp.E.h.Gh.......pVRLWlDDlsuhtplsPshss...h..s.Qhh....pGlplppWpssh...........sshsssDVVIEAFAC-LPtsalpth...............tppptPlWlNLEYLSAE-WVpphHhhPSPpss.s...LpKaFFFPGFottTGG...LL+....EpsL..htpRps.a.pt.....s..ttppshhppl............G.....l........t.....ssshhlSLFuYcsss...lsshLcthp...........pu...s.......psstLLlstGphhssl...tp.h.hs...........t.htsGshhppusLplthLPFlsQpcaDcLLWssDhNhVRGEDSFVRAQWAu+..........PFlWHIYPQ--ssHLsKL-AFLst.hp...s.ths.......t.s..s....s....uhpphapsWNssts..s...........Wpshhpphs.....thpp....pApp.WsppLhsps.D..LuspLspFhp............................................................................	0	20	56	86
+9926	PF10094	DUF2332		Uncharacterized protein conserved in bacteria (DUF2332)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4427)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	25.50	25.40	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.11	0.70	-5.47	37	294	2009-01-15 18:05:59	2007-07-31 10:01:55	4	2	278	0	75	245	44	317.90	35	96.49	CHANGED	ltpsFppQActstphuSPhhucLhttlusphp.stshsupthhsatst..stupulPLRLhGuLHtLlLp.GpsstLsthYsst..pssstsh...sslppsltsapstlhshLcss.PQTNEVtRuAsLhsuhhhlupph.stPltLhElGuSAGLNLhhDRYtaphsss.p...h........GstsusltlsscWpGs...PP..hs...plspRtGhDLsPlDhsssssthpLpuYlWP-p.-RhtchcuAlulstp...ssp..l.cuDAh-hltptL...ttt.psshpllaHolshQYhPstpppthpstlpthGupAs.ppPLsalshE..spt..ssh.sttLp.......lchWssG....psphLucschHGpWlcWt	................................h..phhRp.uhhpspuuSshYptLshtlApD.-...shslhuth...........t.GpslP.hLhGulHhLl..Ls.G..+t..LtpaYsohs...p.........sspsh.........sthpchsppht-plhs.h.Lppt..sQTNEVtRsAhLhsuhthl.......hpph....ptPlsLlElGsSAGLpLhhDpYpYpY....s..ss..p.....a...........Gs.hsSsVp.l....sst..h...p...Gp......sP..hhp.......splVcRhGlDLpPhDlpss-chLhLpuhlWP-..pp.-.RlchhctAhuls+pt.......ssp.......LhcuDus.chLsshh....ttls...c-.AlhslaHohshp.lPt.ph.+ttlcttlptluAp....p..slh+Lh..............ss..cttl+.........................hcha.sG......htcslGcscsHGphhsWt...................................................	0	29	59	66
+9927	PF10095	DUF2333		Uncharacterized protein conserved in bacteria (DUF2333)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5345)	Family	Members of this family of hypothetical bacterial proteins have no known function.	20.40	20.40	20.90	20.60	18.50	20.30	hmmbuild  -o /dev/null HMM SEED	338	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.97	0.70	-5.79	23	372	2009-01-15 18:05:59	2007-07-31 10:02:50	4	2	281	0	102	291	132	236.90	34	85.16	CHANGED	a........................tt...h+hlssshslhlllhhhlGhYWSpEPssFsVpspApptA..............ptpp.....pplVsGYTTTsTLIcls-TLLsKPGGYLSNDlhPPGLahDNMPuWEYGVLlQlRDLu+AhR+-FSRSQSQSsEDtDLshAEPpFNFDscSWhlPSoESEY+cGIctLppYhsRLs-sspssAQFYARADNLpsWLpcVppRLGSLSQRLSASVGpc+lNssLAG-ssu.ppuo.sssphtlKTsWhcIDDVFYEARGuuWALlHhL+AlEVDFuDVLcKKNApVSLpQIIRELEATQpolWSPhILNGSGFGlLANHSLVMANYISRANAAlIDLRpLLuQG	..............................................................................................psh....................................................................................................lsph.LL..K..Gha.ls.D.h.hP...a..hDNhsuaphGh..tlRchuhthhcshuR.pupSt.ct-LttAp.sp.h.......phsp......pu...Wh.......h.......P......p........s.u.YppulctLpta.scLt..........p..tpA.F.uRADNL.paltpltpcLG.ShSthLp................................................t......cssWhp..h..DshFa.uhGthaAh.thhpAhc.DFtpVLtcKph.s.shpph.+pLcss.t..hpP.hl.l.NG.s..s.u.h.h.ssH.hsMu.Yl.Rspusll-lpplLp.......................	0	26	55	78
+9928	PF10096	DUF2334		Uncharacterized protein conserved in bacteria (DUF2334)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5298)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	25.30	25.30	25.50	25.40	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.56	0.70	-4.95	40	444	2012-10-03 16:37:10	2007-07-31 10:03:24	4	6	384	0	94	382	96	229.30	23	48.78	CHANGED	pshlRlEDl.os.....h.ssh.cpL+pls-hlhcpslP..ahlusIPsahsspsth.........ltpssphlpsL+ahps+GGpIh.....LHGYTHph......hsthoG.shEhht........................................pp.thhtp+lpp.ulphhsp.sl.hsssac....uP+Yshoppsh.phhpphFshhhtphthttssh.......................................lpps....t.hhhPpslshl-tsp.............tp..pttphtptspsshsuhFaHsah....h......suhp..........Lpcllsth	..................................shlplcDVsP........h..tshsplctls-hLhc.p.s.lP..ahluslPsatssptth....................ht.t.phsphL+hht.s.cGusIh.....hHGYsHph.................t.su..hc....h...ht......................................sp.phhpp+.lpp.ulp.hsc..t.....pl...hP...huap....APpYthsppsh..ch.h.tph.hs..s.hh.tp...h.tpsh.........................................htp..........hhsp.sht.lp.pp..................t........ht.hthhp.ps..h.shahash..............tht.........l.p.ht..h...........................................................................................................	0	32	54	75
+9929	PF10097	DUF2335		Predicted membrane protein (DUF2335)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5346)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	26.70	26.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.14	0.72	-4.34	15	168	2009-01-15 18:05:59	2007-07-31 10:03:47	4	1	163	0	32	110	0	48.60	33	35.58	CHANGED	PsPslLpcY-pIlPGsA-RIlsMAE+EpcHRHch-ppt.......lctpp+cs+hGQ	..........PPPshLppYcpIhPusAc+lhpMAE+EQs..HRHphp.t............lc.ptp.s+hsp...............	0	10	16	23
+9930	PF10098	DUF2336		Uncharacterized protein conserved in bacteria (DUF2336)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5330)	Family	Members of this family of hypothetical bacterial proteins have no known function.	27.80	27.80	27.80	27.80	27.60	27.70	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.19	0.70	-5.15	75	459	2009-09-11 00:20:12	2007-07-31 10:04:31	4	4	166	0	204	448	45	213.00	19	64.39	CHANGED	VAtPlLppSshLsDsDLl-lspstu.psHhhAIApRtslotsVo-sLlctGstslltpLlpNsGAcloptuhppllcRutpssslttslstRs-LPsshhppLlstsucsl+pplht.ptt.hstpplppsh.....pcutspuss..thsststp.t.spthltpLcpsGc...Ls............suhlhphsppschs.hssAlutLuslshpplcplltcspsculhsLs+ssGLshsshtslhtthtthpph.sh.shpp.............hhspacpl.ssssApplLphh.......c	...............................................................................................................................................................lAtslLtpS..hLp-tsLlphhtpts..t.phhAlutR.tls..lssslhthst..sh..h...htN.tu..hs..sh..hhtt.tt........lt..hh.c.tls.thh..lh....hhs.ttht....t.h............t.htthh...........................tthtt....th...................t..t....h.tthlttlpt.ttp...hp.........................thlhphhhtt..pht.h.tulu.hsshs.thspthh.p.t.tslhhhhcthuhs.thh.hhhhhh....t....t.....thtt.............................h.t.htth...t.....h................................................................	0	59	108	138
+9931	PF10099	RskA	DUF2337;	Anti-sigma-K factor rskA	COGs, Finn RD, Sammut SJ	anon	COGs (COG5343)	Family	This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83 [1].	26.00	26.00	26.10	26.10	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.15	0.71	-4.53	90	784	2009-01-15 18:05:59	2007-07-31 10:05:33	4	6	638	0	335	801	62	181.70	20	72.39	CHANGED	PssplaspI...ptpltspst...........................t.hh...phth...Wpthuh......uusAsAsllslshhhs.............................................ssssshlAslsss.......sussshllphc.....psppl.lhshssssss.ss+shpLWhlsss..ssPhSLGllssssss.h..slssshtsthss....LAlolEP.GGSP.sutPTGsVlhpGtl	...........................................................................................................................Psstlhpp.l......ttlt.ttt...........................................................................................hhp..........phph..............W..+.hhs.h.......susAsusllssshhhh.................................................................................ttshs.sss.h.h.s.ss.hsst.............ssss..s..h...ll..h..h...s...........................pspt.....l...lh.....s.hsh.s.s......ss...sspshplWhl...............sst....ssPhShG.l.h.ss.ssss.h........hlshshhssht..........lulTlEP..tGGSs....pPT.ushlh.h.......................................................	0	106	225	294
+9932	PF10100	DUF2338		Uncharacterized protein conserved in bacteria (DUF2338)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4408)	Family	Members of this family of hypothetical bacterial proteins have no known function.	25.00	25.00	40.00	40.00	24.10	22.50	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.54	0.70	-6.12	6	271	2009-09-11 14:21:54	2007-07-31 10:06:33	4	1	260	0	13	118	0	418.70	62	99.03	CHANGED	hsplLllGoGPsAIQLAlshptHusscluhsuR..sSp+ScRla-AlsptsphhpVuhQNstHpphpGpssIDphaKchcslps-W-TllLuVTADuYhsVLpQlshcsLppVKslILlSPThGSshLVpphLsshsp.-uEVISFSTYhGDTRhlDcp.....................tPp+VLTTuVK++lYlGSo..cusSpplp+LstlhsplsIplpshsoPLcAEsRNlSLYVHPPLFMNDFSLpAIFpsppsPtYVYKLaPEGPIT.slI+cMtthWcEhMplLp+hslpslNLL+FMsDDNYPV+spolsRtDIEsFspLssI+QEYLLYVRYTALLIDPFSpPDEpG+YFDFSAVPa++VapscpulhcIPRMPpEDYYRlthIQulAptLslssPplDphLppYEsulppahDsptcpphSsuF.spsFcpDhslIsppl..psps	.........MSKlLMlGTGPVAIQLAslChL+uDacIDMVGRupoScKSKRLYQAYKK.-+pFEVKlQNEAHQaLEGKF-Is+LYKDVKsV+GEY-TVVhACTADAYYDsLQQLSLETLQuVKHVILISPTFGSpMlVcQFhSKhsp.DIEVISFSTYLGDTRIlDKE.....................sPN+VLTTGVKKKLYhGST....HSNSshspRIoALhEpLKIQLEVl-SPLHAETRNSSLYVHPPLFMNDFSLKAIFEG.TcVPVYVYKLFPEGPITMTLIREMRLMWKEMMsILpth+VPSVNLLpFMVKENYPVRPETLcEuDIE+FEhLPcIhQEYLLYVRYTAILIDPFSpPDEsG+YFDFSAVPFKpVYKNEQcVlpIPRMPSEDYYRTAMIQaIG+hLGlpTPMIDpFLsRYEuospuYpDhH.p-QpLSuQFssshFEtDtALVTKaLc...lNch..................	0	6	11	13
+9933	PF10101	DUF2339		Predicted membrane protein (DUF2339)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5373)	Family	This domain, found in various hypothetical bacterial proteins, has no known function.	29.50	29.50	30.70	29.50	28.50	29.30	hmmbuild  -o /dev/null HMM SEED	745	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.61	0.70	-13.65	0.70	-6.25	47	995	2009-01-15 18:05:59	2007-07-31 10:08:10	4	4	648	0	278	982	83	443.90	16	80.54	CHANGED	lutNhhlplGhlsLhlGssFLl+Yuh-psh..ls.thRlshuhlsGluLlusG.hLRc+............t.shhuhsLpGGGhuslaholhu..AhphYpllssssAF.slhsllsshsssLAlhppu.hLAslGllGGassPlll.SoGsushhsLauYhsllshuhhuluhh+tWchLshhuhshohhhhhhhh....h..ht....h.hssspshhhlaah..lalh.lslhhs..hptt.th.........................hs...ssLlhussllshsLththsp............hhuh.u.lhhuhlhhsls.hhlh+p..thphhhhshs.......................................hlslulsFssLulsluh.ssphpsh.......hWAlpushh........th...........s..lhllsuhhhhhs....................p..hhsshh...lshsshsusahhhthpttttttt................hhhhhuhhhhhhu..hhhtlppt.....................hhhhhsh.shhhhhhh....h..hth.hhhh.shhhh.h................hhh.h...............hth.hhsa..........shshhhhhhhhhhhtt...............................thhhhhhh.hhh.shhhhhth...........shhpthlhshhhhshhhhhh....................h...........shhhhhhh.lhh.hhhhhhhts.hhhs.....slshhPlhN.L.l.hhh.shshlhhhhtp...............hhthshhshhuhhsh..lhlsh.lt+hhpt.thh....................htt.h....phuaSlhWhlhulshhhhuhp...+p.pchlhhsGhuLlulsllKlFllDhuslsslhRllSFlulGllLLsluhhYpphhs	....................................................hhhh.hhhuh..hh.h..t.....hs..h+h.hhhh.u.hhhhhu....h................................................h.s....h..uhuh..h.hh.hhh......h.......h..........h.....h.s..........h..hh.hh..hhuh....t..hs..h.s.....h.s........s..hh....................h..a..hh..h...h.............h...h.........h....h.....................................................................h.h.........h..h........................................................................................................hh...........................................hh..h.h.h.hhh.........t..............................................................h.hh.hhh.h..h.h..h.h.h........................................hh....h.shhh...........................................h.....h..h.....h.h.h........................................................h.............hhhhhhh...hhh..h.................................................................hh.hh..h.h.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.shhh.hh.uh..hhhhhu.....................hh..h....h......uhhhhhhshhKhhhh-h.t...h.+hh.ahhhG..hhhhu........h....................................................	0	90	179	227
+9934	PF10102	DUF2341		Domain of unknown function (DUF2341)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5306)	Family	Members of this family are found in various bacterial proteins, including MotA/TolQ/ExbB proton channels and other transport proteins. The exact function of this set of domains has not, as yet, been determined.	23.40	23.40	23.50	23.50	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.15	0.72	-3.83	55	186	2009-01-15 18:05:59	2007-07-31 10:12:46	4	24	122	0	107	186	82	87.20	28	12.34	CHANGED	scsuDlRFh....sssssp.LsYWlEphcs.....ssp.pAhlWV+lsth.......ssssIhlYYGNssAsssususss......F..hFDsFps...............shaphspssusss	...........suuDlRFs......sscpss..LsaalEpacs......tss..hAllWV+lPpl.s........spsslahYYG..N.s.....s.Ass..s..u..supss..........................FDs.ps................haphstt....s................................	0	33	58	85
+9935	PF10103	DUF2342		Uncharacterised conserved protein (DUF2342)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5282)	Family	Members of this family of bacterial hypothetical and uncharacterised proteins have no known function.	25.00	25.00	30.50	27.60	21.90	24.50	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.82	0.70	-5.48	44	734	2009-01-15 18:05:59	2007-07-31 10:13:14	4	2	468	1	237	622	191	326.50	32	80.26	CHANGED	V.sWcl.AtphApphs..us.......ssssspsststltpuschA-hhlcssTsLsssss......psplhsRscWlcsshssapplscPlspphspthts.....................................hhstluGthhGsQlGtsLuhLuscVLuphDhslshs...............ssGphhLVssNlsphtctLsls.c-hRlalsl+EssHpt.FsusPWLpsalhstlcpaupslshD..s....splpchscphp.s...sspphpph......tuhhcs.postQ+tALsRLpslhuLlEGas-hVhsssssthlPususlpcphccRRt.suGPs-phhtpLlGL-h+.+phccutshhctVsspsGhcstssVWscPDhLPsss-l-sPtsal	..........................................VsashAtphApphs....us.............s...sss.....sttttstltcAschA-halcssTtl.....sssss.....................pstshsRspWlcsshssappls......sPlspp..hstshss.hs.t..............................................hhpthuuhhhGsQlGpuLu.LusplluphDhulsls.............................ssuphsLlssNltshtpsL.clssp-htlalsl+EsAHpp.FstVPWLtsplhutlptaupshplDh.............stlc-hhpphss..............sPp...t.h......pphhp...............tsl.hpshpTstQ.ctALpRL-sLhuLlEGas-tVhstsssshlPusstlpEthcRRRA..su......GP...s.......EphhtsLlGL-h+s+ph+-ussha.ctlspt.....h......GhcutstlWscPDhLPsss-l-sPttal..................	0	72	179	222
+9936	PF10104	Brr6_like_C_C	DUF2343; 	Di-sulfide bridge nucleocytoplasmic transport domain	COGs, KOGS, Finn RD, Sammut SJ, Coggill PC	anon	COGs (COG5085), KOGs (KOG4503)	Family	Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport [1]. Brr6 in yeast is an essential integral membrane protein of the NE-ER, wit two predicted transmembrane domains, and is a dosage suppressor of Apq12, Pfam:PF12716 [2].	25.00	25.00	31.90	31.00	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.86	0.71	-4.65	41	216	2009-12-22 12:56:39	2007-07-31 10:13:49	4	3	159	0	165	210	0	130.40	30	33.73	CHANGED	lstYLQLhhNhllhslllallhthhpsl+pDlpp+hcppptplhtEhppCpcpYhpNpC.s....spp.lPAL-ptCppWccCM......sp...Dsphh.spsph.oAcslucIlNuFlcsloaKohlhllhhhhhhlhssNhshG.hR	............ttYlQLhhNhhlsslhlallht.hlhsl+pDlppphcptptclhtEhstCpcpYhpNcC..ts...spc.lPAL-phCspWccCM......sp.....DPstl...tpsp...h.oAchlA-IlNuFl-slSaKohh....hlhhhlhshhhsoNhshu.hR..............	0	49	97	145
+9937	PF10105	DUF2344		Uncharacterized protein conserved in bacteria (DUF2344)	COGs, Finn RD, Sammut SJ	anon	COGs (COG5011)	Family	This domain, found in various hypothetical bacterial proteins and Radical Sam domain proteins, has no known function.	28.90	28.90	29.30	29.60	28.20	28.40	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.99	0.71	-4.80	74	639	2009-09-14 16:02:11	2007-07-31 10:14:24	4	5	634	0	218	549	66	181.20	28	45.89	CHANGED	RlRl+auKpGph+alSHLDlhRhh-RAlRRuslPluaStGFpP+P+lohAsALslGspSpuEahDl-L....pp..sls.scphhppLstsLPtGlcllpsppl........hpssulsshlssupYplpl...........ss.pphpp..tlcphlstcpl.hp+p.s.K+G+p......phDlRstlhplplpstt...............h.l.h.thhpsssssl+P	.................................+lRl+asKpGph+FlSHLDhhRhFpRAlRRAplPluaSp.G.Fs.PHP+lSa.AsALslGssSpuEYh..-lpL................p.c....sh.s.s...p.....c.......lhppLspt.hPs.Glcllcstch........tptssh.ts...hlsuupYtlph.......................ths.tphtp....tlps.hhst.c.p.l.l.p+to......K.pGp+.............phDl+shl.hp.lphtttp....................l.h....................................................................................	0	113	185	210
+9938	PF10106	DUF2345		Uncharacterized protein conserved in bacteria (DUF2345)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4253)	Family	Members of this family are found in various bacterial hypothetical proteins, as well as Rhs element Vgr proteins.	25.50	25.50	25.50	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.78	0.71	-4.62	93	1108	2009-01-15 18:05:59	2007-07-31 10:15:10	4	20	365	0	273	1206	46	145.80	28	19.47	CHANGED	usssssssth.thspPhllluuPAGIuhsTspohphsAupp.lslsuGpsspluuGpshhssuucslSLFA...........ppsGl+LhAupGplplQAp.s-slplhApcslplsS......spsclplsAppclhLsuGGu.al+lp.uGsIphssPGphplKuAs+shsGPsu	..........................................................................t.....ttthsthtpshllhuuPtGluhsosps....h..phsA.upp..lthsuG.pshsl.ussps.hhhssu.pslolFu......................pptG.......l+lhAu.pG.......plplQAQ.s-.shpl.hA.pcs..lplsS.................s.psclpl...s.Apcc.IhLsuGGu.aIpl.p..susIphsss.GphhhKuuth.h.Gst..................................	0	26	89	172
+9939	PF10107	Endonuc_Holl		Endonuclease related to archaeal Holliday junction resolvase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4741)	Family	This domain is found in various predicted bacterial endonucleases which are distantly related to archaeal Holliday junction resolvases.	19.40	19.40	19.50	72.80	19.00	19.30	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.79	0.71	-4.53	15	76	2012-10-11 20:44:46	2007-07-31 10:32:13	4	2	76	0	29	67	31	142.10	41	87.63	CHANGED	lLllsIlsLhhphhplptch-p+tpphacpWpp..tt............ct....ct-sthppWppccEcclR+-uVp+S+uVltG+loEQLsPaF..P-FcYsPpDARFLGoPVDaIVFcGLo-......G.shpcIVFVEVKTGKsupLocRE+tlR-sI-sG+VpaEll+hc	............................................................................................pphhuclch.+pptltpspKcuVspSRAVLpG+huEQhAPhL..PEFpY.PoDA+FlGsPVDaIlFDGho-.......u.cshpIlhl-VKSG.supLocsppuItpAIccG+VRaEslRl....	0	11	19	26
+9940	PF10108	DNA_pol_B_exo2	Exon_PolB;	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	COGs, Finn RD, Sammut SJ	anon	COGs (COG3298)	Family	This domain is found in various prokaryotic 3'-5' exonucleases and hypothetical proteins.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.51	0.70	-4.80	36	607	2012-10-03 01:22:09	2007-07-31 10:32:51	4	3	575	0	155	1077	343	200.10	36	78.28	CHANGED	s-FL.hhhH+lVuISsl.hc.....ctspF.+Vhsl...us.sts......EpEllppFachlc..chp.PpLVSaNGpuFDLPVLcYRAlhaulsAspaa-tG-........hKWN..NYhsRYpsc.HhDLhDlLutat.spAsssLDplAslhGhPGKhGhcGupVhchapsGclpc......I+cYCEoDVlNTYLlYLRaphhcGplot-sYtpplphlpshL..ppp....s.......ps.+..hptFLpsW	..........................................................-Fh.h..ha+IluIuslhhp..................s.spF....+Vts.l..........st....p..s............................Ecpllp...pF....a....ph....l-..........ca..p....P...p.....L.V..S.aNGpsFDhPlLhhR.....A..L......h.a...s.....l..s....As..p...a.a-.h.sp.........................................K.WN......NY.h.s..R....a......p..p....p.........H........hDL.....h-....h..L..u.....h.......a...t.......sp..t....shsLD..sl..s.p..h..hG..l...P...G...K.....h...s...hcGs....pV....h..c.h.a.h......p...s..c...lc.c.........I.c.sYCEoDVlNT..Yhl...aL+aplh+Gt.lstcp.Y...lt.hpphL...tp..pts..aht.ahts...............................................................................................	0	53	109	133
+9941	PF10109	FluMu_gp41		Mu-like prophage FluMu protein gp41	COGs, Finn RD, Sammut SJ, Bateman A	anon	Jackhmmer:Q1GH51.1(1-98)	Family	Members of this family of prokaryotic proteins include various gp41 proteins and related sequences [1].	25.00	25.00	25.10	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.72	0.72	-4.06	114	1089	2009-01-15 18:05:59	2007-07-31 10:35:28	4	3	785	0	169	674	13	81.60	26	78.61	CHANGED	slpL.ppP...hph.sG...pp.....l...splsl.RcPpstDhcshp.........t.sp....ssc....tp.....htl....luplsu..ls.c-lppLshsDasplptthsshht	......................lpLppP...lptst....pp.........l...spl..sL...+cP..s.stsl+usp..........................shts........-ss....th.............hpl......lsplos...lstp-l..sphch.sDhtsltttlhsFh.h..........................	0	32	80	130
+9942	PF10110	GPDPase_memb		Membrane domain of glycerophosphoryl diester phosphodiesterase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4781)	Family	Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase.	28.90	28.90	28.90	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.67	0.71	-4.78	31	1075	2009-09-11 03:27:55	2007-07-31 10:36:16	4	4	932	0	95	639	6	147.50	28	26.66	CHANGED	llYhpFuhLllshhplhtpp.ho....hcplhpp.shpplpplpssshlahlhYhlLllPFu..slshposLLsKlpIPpFI....h-alhpshhh.hlhhhlhhllhhalulRLlasLPlhllppp.sh+pAl+pSWphT+p.phhphlhhhlllhhhlsh.l	......................................llahphuhLlhh.shthh.pcp.hhp....h+plh+p.shth.l++.lhshph.lahhhYh.h.....lllPhh..shhhp.os..llspIhIPpFI......hs..L...hc.shhh...hl.....shhhhhlll........h.....YlslRLlF.s.LP.hhllccp.shpcAh+hShphTK+....pha+llhhhlhlhhhlh..hh.......................................	0	31	64	77
+9943	PF10111	Glyco_tranf_2_2	GlycosTransf;	Glycosyltransferase like family 2	COGs, Finn RD, Sammut SJ	anon	COGs (COG4092)	Family	Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis [1][2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.65	0.70	-5.32	12	436	2012-10-03 05:28:31	2007-07-31 10:37:56	4	22	388	0	82	19422	6862	205.20	17	53.59	CHANGED	SlIIPlthutt...l.c+l...Ltptpph..s.shpllls-ssssh...ppltplhsp.tth.hlpppstpphhu.utsRNtusphu....pochlhFhDlDshhs.shhpphlp.....tlpps.sthhhlPshYLsppuspthhp..t.h.cpthhcshhs.ttshht........hu..o.ushlhp+chFltlGGaDEsFhGaGhEDhEhhhR...Lthhthth..scshhh.chtphshh.........pGFRtaFthhuhshh...thhhh.HhaHppsptpsYh..pppttNcthh.pph+.h	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...............h......................t...........u....h.........h...p...N.........h....u...h.....t.........s...................p.s..p....h.....l.h..h.h..D....s....D...h....h.......p.......p......h...t...p...hhp.................................h.t.....t....t...............................h........h....h.......h................h........h..........h..............s......t...........................t........s..........p......................h......h.......p.................................................................t................................h....................p........p.....h......h.....t...................t.......h...h.t.........................................................hh..s........h......o.....u.......s.....h......h.....h..p....+.p.pa.....h....p.....l......G...........G.......a...-..E...s...a............h....s......a.....G.......h.......E...D.h...D..h..h..h..R.........L..h.t..h..s...h.......h........................................................................................................................................................................................h........................................................................................................................................................................	0	28	53	67
+9944	PF10112	Halogen_Hydrol		5-bromo-4-chloroindolyl phosphate hydrolysis protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4915)	Family	Members of this family of prokaryotic proteins mediate the hydrolysis of 5-bromo-4-chloroindolyl phosphate bonds.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-10.96	0.71	-4.91	20	680	2009-01-15 18:05:59	2007-07-31 10:38:18	4	3	601	0	75	370	10	187.00	27	78.74	CHANGED	M+hhhphll.hshlGhshhslshhsshhuhs.sFll.uhlluhuuhhssahsspphspt+.............alccpGLocc-YcYl+psLcEA+pKIppLpKshhpl+slpshcpsp-lh+lu+pIaptl+p-Pp+FacscpFaYp+LDslV-LoEKYshLsppPhKst-hppsLccTRhTlccLscslppDLpclls-Dl-sLDhEl-lAK	.................................................................................................................................................................hu..hhhlh.hhhhh.............h.....sh.l..hhs.h.hh.h..h..h..h......h.pphtptK....................................ahpphGLo.cp.-.h..c.h...h+pplscs.+...pplptlpcshs.ph+sl+......s....h.c.plschhplu+uI..a.pplcpcP.pph.hcscpFhYs+lssslcLs-pYscltc..pshK.spphpppLcp.o.ctslDplpcsltsDhccLhp-Dh-cLDhEhclsK................	0	24	48	61
+9945	PF10113	Fibrillarin_2		Fibrillarin-like archaeal protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4018)	Family	Members of this family of proteins include archaeal fibrillarin homologs.	25.00	25.00	534.40	534.20	18.10	17.60	hmmbuild  -o /dev/null HMM SEED	505	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.56	0.70	-6.16	5	30	2009-01-15 18:05:59	2007-07-31 10:39:21	4	1	29	0	19	29	1	505.70	56	99.96	CHANGED	M+DLI+EAlNDLDAAhEL+KLhhp.......tEpslpEVVDAVsDLScEEtpKLGusFRRFPLGCDLlEIuVGPCASDLohsslLuNClLADpMGhPIHVCAYAlADIAEsaGM+PIELh+EVhENVEVPLDLDHFGRYGPMRFP+-ITuCtGsCYhEGPPFKGCPR-RIH+RLIDKE+EtusDhEEWlKLASSVCVNVTsEQG..A-sHAAPL-EMc-VAEsARKaGKGVEAIhHVGDGYDDLIoGlKAul.DlcVDVFVlEGGPFNRAcDRLcAFA+AVAluRILVPGKVVATNGAYEDECRVGLRAGLNuILTGFP+NHHGYMCGYSPGTARRGpFGLPRVL+IMKEEl.uc.slTtsPlsK-pLEALARAs+FLGsN...hVYPpcIGshYlGDAHW.AuLssoslac+s+lsKTV--l....tst.suDTVALLGGRFlSWuIAcKLDtl.V-EllISDsDPWVE+ATV+lLs-ELcsslaussGDD+KAlEpADsSlITTsIPpIut+IupKhsDAlT..Ll	M+-LIK-AlN.DhDuAhELpKh..........t-pDllElVDAVsDLShE-h.KLGusF++FPLGCDLsElsVGsCASsLsLhplltNClLoDhhGhPIHlCAYAlADIAE+cGhpPlEVM+cVh-sV-VPLDLDHFG+aGPMRFPK-ITtChG-CYhpGPPacGCPR-RIHKRLI-KEKEtusEh--WlKLSSoVsVNlspEQG..uEsHAAPL-Ehc-VAchA+KaGKGlEuIhalGDGYDDLIoGlcAsl.DlsVDVFVlEGGPFNRAKDRLcAFAKAVAsSRILV.GtVVATNGAYEDECRlGLRSGLNsIloGFPtNHHGYMCGYoPGTARRGNFGLPRVh+IhKEEl.ts.slshs.lsK-.LcALApusKFLshp....IYPp.pIGsaalGDAHW.sslpsSslYcplp..lsKTl--l....tpt..ss-KVulLGGRalSWuIAccLc...s-ElhISDsDPWVE+sTV+lLs-s.shssassNGsD+cAhcpADpolIoohIPpIshKIpsKh..-Ahsl.........	0	5	9	15
+9946	PF10114	PocR	Hist_Kin_Sens;	Sensory domain found in PocR	COGs, Finn RD, Sammut SJ, Anantharaman V	anon	COGs (COG4936)	Domain	PocR, a ligand binding domain, has a novel variant of the PAS-like Fold [1][2]. Evidence suggests that it binds small hydrocarbon  derivatives such as 1,3-propanediol [1]. 	20.70	20.70	20.70	20.80	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.01	0.71	-5.11	71	805	2012-10-04 01:10:46	2007-07-31 10:40:04	4	113	595	0	236	604	20	166.20	26	39.32	CHANGED	lp-l.lDlptlQpl.-sFschs.tlshsllD.hcGpsl..tss..sapchC.chhRspspspcpChcSDtphu.puht...G.c.tlY+C.+sGlhDhAsPIhlsGpalGslhsGQhhhccps.-h.hhpptup.chGhsccp...altAhccVPhloccplpsshphhhplushluphuhpplphtp	.....................................................................hls.chlpcltpsFupuT.slAhll.....Vc...hc.........Gp.........l...o..chs.......sa..s.sFC..phh..Rp..ps....p...tp.p.p.Cpp...s.Dtp.u.G.hc...As+..............ss...pP.hI.Y+C.HsG.Ls.DhulPlll.ss.p.hlGhl.ls...GQVh.h...p.s..s..sc.......t..h........h...p..h.........s........c........s....h.ptc........hhpt..hpplPhhshp.cltssuphLthlsp..hhptthp......t.........................................................	1	116	193	212
+9947	PF10115	HlyU		Transcriptional activator HlyU	COGs, Finn RD, Sammut SJ	anon	COGs (COG5453)	Family	This domain, found in various hypothetical prokaryotic proteins, has no known function. One of the sequences in this family corresponds to the transcriptional activator HlyU, indicating a possible similar role in other members.	21.30	21.30	21.30	21.40	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.09	0.72	-4.15	31	240	2009-01-15 18:05:59	2007-07-31 10:40:28	4	1	238	0	48	133	8	92.50	49	97.45	CHANGED	M...uhhs+LF....Guuptst.......pscP....-YcGFhIhspPhpEuGQaRlAupIpKcl.sGEh.KsHcFIRuDllsoc--Ap-hsl+KA+hhIDQpG-plF	................MuhhsRLF.......Guspt.sEss........psEPh.....EYKGFhIhspPhu.EuGQaRVAG+IoK.pI..sGEl..KsHRFIRuDlhs.ucpDAt-.lhL+Kup.hIDp.GspIF..........	0	9	23	33
+9948	PF10116	Host_attach		Protein required for attachment to host cells	COGs, Finn RD, Sammut SJ	anon	COGs (COG5622)	Family	Members of this family of bacterial proteins are required for the attachment of the bacterium to host cells [1][2].	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.28	0.71	-3.95	79	395	2009-01-15 18:05:59	2007-07-31 10:41:06	4	4	363	0	166	378	47	128.90	23	82.09	CHANGED	sallVADup+Aplhpspus.....tt.s.h.tltph.c.psp.tsp-lss.....D.psGc.hpstst..t..............ut.tps-h+phpccpFAcplAshLpc..ttppsch.ccLlllAsPphLGtLRppLppplpptl.hsElsKDLTp.t.....ssp-lpptl	..........................................hllVsDuppAhlhpstst.........th...h...ht...ph.p.pt...p.t..spphsss.psGp..t................................sh.tpss.....pchp..ccpFA+plAcpLpc..t.spp.tca.cc.LlllAsPp....hLGtlRppLsptlp.phl.ht-lsKDLsp.h.shpclpctl........................................	0	49	98	125
+9949	PF10117	McrBC		McrBC 5-methylcytosine restriction system component	COGs, Finn RD, Sammut SJ	anon	COGs (COG4268)	Family	Members of this family of bacterial proteins modify the specificity of mcrB restriction by expanding the range of modified sequences restricted [1][2].	20.90	20.90	21.10	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.94	0.70	-5.51	40	909	2012-10-11 20:44:46	2007-07-31 10:41:42	4	2	849	0	160	671	83	298.40	25	74.67	CHANGED	l........+spsYVGhlphsss......plEILPK..hsppss................................................+phLhpMLp...........hstslp.hppsshsslpptch.sLhElhhhh..Flptlppll++Glhp-Yhphp-spphl+G+Lplsppl+pss..sppc+htscaD.Fs.Dps.NRll+suLchltphs............psssshc..hlpcltshh....p-lshsp.stpshpphp..hsRhhscYcslhthsclILpp..psshstpGcp.pshuLLFsMpplFEpYVu....thL+................tplssshplcsQsssha.Lssc.pspth......FpL+PDl..llpppspt...............................hllDTKWKhlps.....tpphu..lupu.DhYQhhAYuptYpssput......LlYP	...............................................................................................................................................................................................................................htshhGhlt.h....t..t........lpl.s+hs..t..........................................................................p.hL.hhhLp...........................................h..hshh...hp.h...s.p..h.ss..h..tppc...pLhp.lh.hhh...F.ctl.pt.hl+..+G...Lh+-Yh..php.cs...s.h.l+Gclplp.pp.l.+p..sh..shp..tp.h..t..sphcEaohDsshNpll+ps.l.phlh.ppp...........................p.sp.pphp........plhc.l.h.ha................pt.l.s...h.h...p......h..p...ts..h.....sphh........hpphh....ppYctl.hphshhlLpt......tp..s...h..t...t..up...p......c.....h..h...u....h....L......F...s...hpt....LaEcaVh...........phLp...................thh..t.s..p....p.s..p...s.p...s...t..sha......hlsp......................h..plp..PDh....hh..c..p.p..t....................................lllDsK.a..Kthp...............spps...lsps..DL.aQlhuYsht......hpttps...........LlaP.......................................................................	0	51	99	130
+9950	PF10118	Metal_hydrol		Predicted metal-dependent hydrolase	COGs, Finn RD, Sammut SJ	anon	COGs (COG3687)	Family	Members of this family of proteins comprise various bacterial transition metal-dependent hydrolases.	30.00	30.00	30.10	34.80	27.30	29.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-12.03	0.70	-4.93	54	983	2009-01-15 18:05:59	2007-07-31 10:42:16	4	4	332	0	205	849	96	251.60	30	85.30	CHANGED	lpsRclcF-hss..hs..taWhss-PhsTphhNuLSlhhPtGEpaFlcul+phpstl.....pDscLpp-lcuFIuQEAhHu+pHpthNp..tl.ptpGhs.lpt.h-thhphhhphhtc................hs.htpLAhssAlEHaTAlluchlLp.p.phh.tusDPphtcLacWHuhEEsEHKuVAaDlattlsu......pYhhRstshhhsohhhhhhhhtssth..hlppD.........tthhp.h+.shhcsh..phhh.u.t........Ghhp..thhsshl.sYac..PuFHPhpc....ss	....................sRclcFshss....hs..hpW.h.ss.sshhTHhhs.sLShlFPsGEcaFlcosRphp...spI.....pD.s....p.L+pclpuFIGQEAhHo+tHpthNcth..pptGhs...sct....hc....phth...hh...hp.hhpc..............hhshhhpLuhssAlEHaTAh....luchlLs...s.ph............tssDsp.htsLahWHuhEEsEHKuVAaDVaptltu.........sYhhRhtshlh.shs....hhh.sh.hh.h.hshh....hhppD..........tthhp..hc..shhchh..phhh....t...........uh.hp...thhtphh.sYh+..PsFHPtpps.t........................................................................	0	53	112	163
+9951	PF10119	MethyTransf_Reg		Predicted methyltransferase regulatory domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4797)	Family	Members of this family of domains are found in various prokaryotic methyltransferases, where they regulate the activity of the methyltransferase domain.	25.50	25.50	26.60	28.10	22.80	25.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.75	0.72	-3.49	20	365	2009-01-15 18:05:59	2007-07-31 10:42:41	4	17	288	0	96	333	26	85.60	31	15.60	CHANGED	ppsctYLhHEYLpthNpPhYat-FssphuptsLpYlu-ushtcshsthhhspst..pthltthscshhp..EQahDFhssRpFRpoLls+	......................tsctYltHEYlpt.NsshYapcFhcph.pcpp....LsYluDsslpsp.a.sshhsp.pst..pph..lptss.cshhp...EpYhDFlssRpFRpoLls+.....................	0	29	55	72
+9952	PF10120	Aldolase_2	MethylPyrKinase;	Putative aldolase	COGs, Finn RD, Sammut SJ	anon	COGs (COG1992)	Family	Members of this family of archaeal and bacterial proteins are likely to be aldolases.	25.00	25.00	27.20	49.10	22.70	23.20	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.86	0.71	-4.88	52	250	2012-10-03 06:25:16	2007-07-31 10:43:11	4	10	148	6	156	245	49	164.60	30	46.24	CHANGED	cplpcAlphltppst.hspLIPEVtoNluhuls...A+shpDVAulsGR.Isphts+stssusspFGuSpHlARllLsshchsschRuslNl+Ysccllcth....cchGhclsph-RppEPppsp.....oh.ahlcpshcph..sphPDl..IaDpGshGKEPhlhlhGcssh-Vlcplhpl	..........................................plcpAlph.l.tptpt.hhtLIPEVtoNluhuhs...AcshpDVAulsGR.Ih.p........h.tspshssusspFGuSpHlA+hlLsshchsPpl.RushNl+Ysccllcth....cp.hGhplsphccpp-Pppsp.....sh.ahlcpsh........pph..........sp..............sPDl..lh-pGshGpEPh.lhlhGcssh-Vlc+lhp.............................	0	38	83	123
+9954	PF10122	Mu-like_Com		Mu-like prophage protein Com	COGs, Finn RD, Sammut SJ	anon	COGs (COG4416)	Family	Members of this family of proteins comprise the translational regulator of mom [1][2].	22.90	22.90	22.90	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.96	0.72	-4.91	6	135	2009-01-15 18:05:59	2007-07-31 10:43:53	4	2	114	0	27	112	2	45.50	40	68.66	CHANGED	Mh+slRCGHCpKLLARhsshspLpIKCPRCtTLNHV+AsShp.p.Pp.p.pc	.........+slRCspCsKLLu+h......s.shs...plpIKCPRCtslNp.................pt.................	0	10	15	22
+9955	PF10123	Mu-like_Pro		Mu-like prophage I protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4388)	Family	Members of this family of proteins comprise various viral Mu-like prophage I proteins.	21.90	21.90	22.10	22.40	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.02	0.70	-4.98	21	423	2009-01-15 18:05:59	2007-07-31 10:44:10	4	6	304	0	68	385	21	247.10	23	86.85	CHANGED	lpLlPtGpFpupDGRs.p......ssWhlssssuttllsphs...ttttclsIDYEHQTlh.ttppGpPA...PAAGW..lcplpaRssc...GLa.ucVcWTscAtphIcscEY+YlSPVFhaDpssGplhplhsAALTNpPuLssht..tlsAlss...............t.s..pcpp.sphlctLhthLGLsssuss-t..............hh...........sthsssttsshsshtsshsthsttptphsshss..t..........sDhupalPlsshptl.......psclssLpsphsshph....-thlssAlp-G+lhPup.+sWuppLuppss..suLpsalssssslsALsupQT....h.sssststsusLos--hulsctLGlot--ahK	...............................................h.P....G......h....s.....pu..p...........h.hs..t.htth.h.ttht...t......t...sl.h.lDa-Hpshh.........st.s.......sA.u.GW....hp..t..h.hpts......u.l.h.sp.s.c...as.pu.tthltstpatalSsl.h....h...st.t........G...th....h......p.....lh.........sAL..TNp..Psl.th.......lh..shtt..................................t..t..p.....p..hpt.lhthh.s....l....ssstt..............................hh.................t..t........t.t.....t........t.......t.........................................................................s.t.hh..h.t....t.h.pt.l..........ttph...t...shp...t...p....t...ttth..........pthlptAhppG+.l.h..u.....ctah.thstp.....tthpshl..pt.t......s..shst.p......................t.....................................................................................................	0	22	44	57
+9956	PF10124	Mu-like_gpT		Mu-like prophage major head subunit gpT	COGs, Finn RD, Sammut SJ	anon	COGs (COG4397)	Family	Members of this family of proteins comprise various caudoviral prophage proteins, including the Mu-like prophage major head subunit gpT.	20.10	20.10	20.30	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.92	0.70	-5.44	23	696	2009-01-15 18:05:59	2007-07-31 10:44:45	4	10	447	0	86	552	204	140.20	27	35.41	CHANGED	LpuLhsuFpssFpcGls.tAsopasplAhhVPSootsssYGWLGphPphREWl.GcRllpslpuaGYsIpNKsFEoTVuVsRsDIEDDplGlYuPlhpEhGcuAutaPDELlFuLLKsGFoThCYDGQsFFDTDHPV.spssGTsssVusss.............ussGssWFLLDsSRslKPlIaQpR+thpFsshscss.D-pVFhpscahYGVDuRsNVGFGFWQhAauSKp.sLsusNatuAhpAMpuh+uDuG+.LGI.....+PopLVVPPsLEpsAccllps-...hssuGu..o......Nsa+s.sscllVsPaL	................................................................................................................................................................................................................................................................................................................................pt..hs..htsh.tAhphMt.h.p....t.-.st+......LsI.....pPs..hllVPsuhEshApp.llput......htsus..............Nshps.hhplls.s..th.............................	2	32	59	73
+9957	PF10125	NADHdeh_related		NADH dehydrogenase I, subunit N related protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4078)	Family	This family comprises a set of NADH dehydrogenase I, subunit N related proteins found in archaea. Their exact function, has not, as yet, been determined.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.20	0.70	-5.18	8	32	2012-10-02 00:39:38	2007-07-31 10:44:57	4	1	32	0	21	166	53	219.20	57	99.39	CHANGED	Mh...o..IuGplLslIPFGDIVhYhSsaohlhFlsAlhFTlllhlo+PE+QlEhpaGp.u.+hcpVsscEhRh+RFMAIlCGlATsGAhlTGDlFNFoLFlAlIGIsNIGIV.oAV+pcaVLsAAFpYGllAMlATLPLFGGAAlILAsTGTLSIaELuth...uts.hllauKlLLslGVlGEsGlAPFYAAKAEhFRAPGAPYILMIHLSSLLlhlRslEILLol	.................................................................h....tsluGphhGhlPhGDIVhYhTsFollhFlsAllFThllhloKPE+QlEAphtchGs+hphVshc.EhKIRRF...MA..I...l...C..GlA.T.A..GA.M.l.TGDLFsFsLF..lAlIGIsNIGIV..SAV......K.p.c.a.VLNAAFpYGlIAMlu.oLPLFGuAAllLApTGTLS...laELu.ph........sss.....llat.K...l...Lh.slGhh..G.EoGlAPFY..AAKAEMFR.APGuPYI.LMIHLSSLLlIlRslEILLol................................................................	0	5	11	17
+9958	PF10126	Nit_Regul_Hom		Uncharacterized protein, homolog of nitrogen regulatory protein PII	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4075)	Domain	This domain, found in various hypothetical archaeal proteins, has no known function. It is distantly similar to the nitrogen regulatory protein PII.	22.90	22.90	22.90	74.90	22.30	22.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.23	0.72	-4.29	6	33	2012-10-01 21:59:08	2007-07-31 10:45:06	4	1	25	0	24	32	0	108.20	47	95.18	CHANGED	M...........................................+lhl+LFVEsENlGKshNhLo-sGITGFYlhEY+GhSPscWKGFplc..EDPEhAIchlpDhSccAVlIsTVVsEEplc+IcchlcE+Lss-RYTlIclPlppIcVsts	.....MKlLl+LFVEs-NlGKAINALoEuGITGFaLhEY+GMSPp-W+GFhlp..EDPEhAlcllp-hSpsAVlIsTVVsc-pltcIcchlcE+Lps-+YTllElPlhsIpVNt...	0	5	10	18
+9959	PF10127	Nuc-transf		Predicted nucleotidyltransferase	COGs, Finn RD, Sammut SJ	anon	COGs (COG3541)	Domain	Members of this family of bacterial proteins catalyze the transfer of nucleotide residues from nucleoside diphosphates or triphosphates into dimer or polymer forms.	21.10	21.10	21.10	21.30	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.69	0.70	-5.03	47	840	2012-10-02 22:47:23	2007-07-31 10:45:28	4	4	657	0	203	769	31	217.10	25	84.92	CHANGED	M+ppl.pcLpclEpcp....sl.........+lLaAsESGSRAWGFsSs..DSDYDV..RFlYlcsh-aYlul.......p.t..+DVIEhslscpLD.lsGW-L+KsLpLht+uNPsllEWLpSPll..YhpssshhpplpthspchFsscpshaHYluhAppsh+pa....Lpsc..pl+..........hKKYhYlLRPlLuspWlpptts.hPPhpattLhtth...ssslhsclspLLshKpputE.hphhst..hshlcsalcpp...lcphpphspt.pp........schptLsphhhc	............................................................................h.th.tp........th...........pllauspSGSRuaGhso.......-SD...h..Dl....Rh.lal.ps.h.cha.l.pl..................................pt.....c-sl....E...h...s...h...s...c...p......hD..lssa-l+KhlpLhtpuNPsllEhL.tSPhh....h..p..p..t.p..h..ht...th..h.th..s....thF...s.pts..h.h+Y...huhAp..pph+ph..............hpsp.....ts+......................................................hK+hhalL.Rs.llssphl.ttt....s....h......Ph...................t.........hhtphp.....tLLthKptt.p.ht..........h.....lp...t.....hlptp.......ht.ht......s.h.pt......sht.lsphhh................................................................................................................................................................................................	0	79	146	177
+9960	PF10128	OpcA_G6PD_assem		Glucose-6-phosphate dehydrogenase subunit	COGs, Finn RD, Sammut SJ	anon	COGs (COG3429)	Family	Members of this family are found in various prokaryotic OpcA and glucose-6-phosphate dehydrogenase proteins. The exact function of the domain is, as yet, unknown.	21.30	21.30	42.30	41.80	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.75	0.70	-5.49	65	561	2009-01-15 18:05:59	2007-07-31 10:47:06	4	3	535	0	172	439	195	257.90	38	76.06	CHANGED	sssshSpp+PsRlIsl...shssspss......................................L-ApVps........GussusuEhllLRssussh.pcstulVhPLLlPDhPlhlWWsus.sPssshhc.LuphupRhIsDosthss.PhtsLpthtp.....shssussDLsWsRLosWRphLAtshDtPspcs....lsplslsst..ss.....sP.suhLlAuWLAsRLshslppttstt......................................slhulcLtsp.......ssslhLs.stsut.shplptsGtss......pslslscpsspphLAc-Lc..RhssD.lYtpul	..............................hAscAS+cHPsRlIsl......spssscss..........+........................................................LDApl+s............Gu-..uGsuEhlVLRhpGshu..p+ssSVVhPLLLPDsPVVsWWPss.u..P..s..ssu..pD..slGtlApRRIT.Dus.ss...pc..PhpsLtp..h.ts.......sassGDoDLuWsRlTsWRulLAuAlDQsPtp......lpus..pVput.....ss..................sP.sstLLAuWLutRLssPVp+ssstss........................................................ulhslpLsps..........suslhlpR.s.sup...hAslph..sGpss.............phluLs+Rs...st-hLuEELR..RLcPDclYstul..................................................................................	0	53	128	162
+9961	PF10129	OpgC_C		OpgC protein	COGs, Finn RD, Sammut SJ, Bateman A	anon	COGs (COG4645)	Family	This domain, found in various hypothetical and OpgC prokaryotic proteins. It is likely to act as an acyltransferase enzyme.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.37	0.70	-5.77	62	563	2012-10-02 17:00:17	2007-07-31 10:47:48	4	3	419	0	168	593	70	345.30	29	88.01	CHANGED	RDhR.lDhaRGlALhhIhlsHl.....Psshhp.hlTh+saGFSDAAElFValSGhssuhsY.uphht.....cpGhhsust+lh+RsaplYhAalhlhhhhlshhuhhuhhh...psphlpph.....................slthhhppPht..slhshlhLpapPshhslLPhYlllhhhhPhllhhhhpt.sthslusShsLahsAthht..........hslssaP...sshtWaFNPauWQlLFVhGhhhuhthtpt....thh...hpthlhhlAhuhllhu.hhhthhhhh..h.t.h.......s.hh.thhhs..hsKopLu.hRllHhLALualssphls.tshthhp............t.hhpslhhlGppSL.VFssGshLuhhsphlhtth.ss....shhhp...hll.shsGlulhhulAhhhphh+p	.......................................................................Rphc.lDhaRGLsLlhIhlsHl..........sssl...lp.....hh.....T...h+.....s..a.....Gh.s.....D.......A.....A..EsFVFlSGhssuhsY.uph..hh.....c.t.sh.hsus...t+hh+RuhplYhsalhhhhlhls.hhs.....h.......hsh......h.hh.......ps.hltph.....................sl.sshhppPht......slht.h.l..hLphpPshhsl...LPhYll.....hhlhh.PlhLhlhppp...h...hhLuhS.....sslWhh.uthht....................h..shsshs..ss.hW....a.FNPhuW.Qh....LFshGhhsshtstttt.....hh......hp.....h.lh.hl.usu.hl..l.hs..hhht......hhhhhs.h.................hh...h.hhs....sKspLuhhRll.phlAluaLhsthl.....hh.thhh............shhhcslshlGcpSL.lFshGshluhhs.p.hhhhhs..ss.........shhhshhlshsulshhhhhAhhhph...t...........................................................................................................................................	0	30	79	113
+9962	PF10130	PIN_2		PIN domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG5378)	Domain	Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	21.90	21.90	22.00	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.69	0.71	-4.12	15	82	2012-10-03 20:43:45	2007-07-31 10:51:19	4	1	55	0	44	124	12	122.10	24	90.15	CHANGED	VlDANIlluulLt................................cs+phhlhhsttlchassptshs....Elp+ahstlspppplstpphtshLp....tLhptIpllscslap.phpppAccRhtchDscDaPhlALuLhLsusIWT-D+DFhssGlso.................WTocplphhLs	...................................llDsNllhusllt................................t.hh.hhh...h.....ttphph.hss.phhht....Elccahttl...h....c....t.pp..l..st...cpht....p.hlp....hLhp..h.lplls..pphht..phhppAhphhtp..h..D....c..DhPalALuLtl.....ss...l.W.TtDpch.....................................p.........................	0	15	36	40
+9963	PF10131	PTPS_related		6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG5617)	Family	This domain is found in various bacterial hypothetical membrane proteins, as well as in tetratricopeptide TPR_2 repeat protein. The exact function of the domain has not, as yet, been established.	22.90	22.90	23.10	23.30	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	616	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.99	0.70	-6.37	10	172	2012-10-03 03:08:05	2007-07-31 10:51:56	4	6	156	0	45	127	60	380.40	25	62.59	CHANGED	hRYauPLuYalhAsLphLs.GslhpuatlhlhLshhlGAlu.Whhas++pGp..hluhlsulLalhhPtpl+lhahEGNlPpsss......huLsPhll.lhLahhhc++chRsllshsLhhsllsLoHhMhuAlssluhhlh....lLlhtlh.pp+hlpplhulluhslGls.............huSaWllPhL..+sGlssh-ssusutVhcshohshosuLsPhh......t.uhaYaGlulsllhluGlhhsp+++ssu....................hlssllhllhohsuslsllhpLPlspLlh.hRFsshA..huhllsuhhhhtph+K.........hhslhslhlul...LllDossshphlsassscstpstppl..pptcshscpRlull...DtoshGohsoaal...sshsspsplhGWsaQGusTupsIhhLNpAL-s.......tYatahFDsshphsspolllp+tllocpt..hptlcpss......thsGYphhpcsscthlYp.....ps...sspsatshsphhGlsIG+suh-lsLpasthcsussshl-....Dholp-Lp..+acllYLouhsh+scuphEt.................................................llh+lu+sGs...............pVll-hsch..p..scpstFLG............Vpupshshcs.chpshhasspchsssh.FtpcttpWpsshhsssp..hpshh.lsc+tlthhh+stpss........................plYFlGhNLhaH	.......................................h...sahhhshLhhlh..u....hhu...h...hh.h...hhs.shl.u.sh.....u..hY.....hhu.+h.h....sh.p+ptuhLhulLYhhuhYphps.las.RssluEhlA........huhhPh.lL..h.sh...a.hl.h.p.ct..p...p+.h.hhhLsL..uMohlshu.H....hlohh.hs.s...lhlhla.......llh.h.h........pp......p.....hht..l....h..h..h.h.u...h..shu..ls....................................................hh..aLhPhl............hsss....pp...hp...s.........p..lac.s.h..s....p.sh.s..hh.p..h.......................sh.h.h....l.GLl.lhl..lt..L..hu.hh...hp..t..++.hlh......................lshl.lh.Lh..so.o..h.hPh....h...h....lp.....p..hPhpp..l...Q.F.....P..aRF....lslh.lh..huhh...lu..s....h....t.lh++..................hhhhhllhLsl...........sls.h.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p...pp.thhhhtt...........................................................................................................	0	20	30	36
+9965	PF10133	RNA_bind_2		Predicted RNA-binding protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG1532)	Family	Members of this family of bacterial proteins are thought to have RNA-binding properties, however, their exact function has not, as yet, been defined.	20.60	20.60	22.10	29.20	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.76	0.72	-3.94	20	129	2009-01-15 18:05:59	2007-07-31 10:56:29	4	2	114	0	73	120	3	60.10	34	92.39	CHANGED	MCEuNlYL.hpsspcELlMEsVshlcsps-sl...hLpsIhG-pKhlcu.pIKclsLscH+Illcc	..MCEussYl..hps.spccllMEsVsplpsps.s.p.l...hLpDIhGcpKhlcu.cIcclsLhsH+Illc........	0	32	55	67
+9966	PF10134	RPA		Replication initiator protein A	COGs, Finn RD, Sammut SJ	anon	COGs (COG5534)	Family	Members of this family of bacterial proteins are single-stranded DNA binding proteins that are involved in DNA replication, repair and recombination.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.42	0.70	-5.08	32	404	2012-10-04 14:01:12	2007-07-31 10:56:48	4	2	282	0	162	499	117	222.40	33	63.88	CHANGED	+DshssM-aPlFSLupp...chp..slpYctss..splpVpsusc..GhATIaDtDILIassSQlhcA.......tstG....cs.o...Rhl+hTsa-lLthssRsTuGcsYpRLctAh-RLpuTsI.....pTslc.sssp..cppcsF.ulIsp.aphl..sc.t..sGRh...hulElpLs-WlYculh...stp.VLTls.-YF.cLppsLERhlYcLA...RKH.sGcQst.WphslppLpcKSGSsush+cFptplRcllpsss...LP-Ypl	............................................................+Dt.shMtaPhFSLuKp....tcht......slcactss..........hplcVp.....us...sch..Gh..ATIa.DtDlL..Ias.sSpls-A..............pstG.....t..u......Rhhpho.s.a-lL.p.hhsR...s.s.uuc.sYpcLcsALcRLpu...Tsl................p.T.sIc....pssp........pc...pcpF..uhIsc..ac.h.........scp.........sG+h........hsl-.lhLs-Whapulh.....psh...VLT..lc...s.Y.F..pL.pts..l-RhLY+ls.....R.KH...sG.c.p...tt.........W..phshppLh..pKoGSh.u....hp...cFth.lRtlhttp.......LPsYt..........................................................................................	0	34	110	139
+9967	PF10135	Rod-binding		Rod binding protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG3951)	Family	Members of this family are involved in the assembly of the prokaryotic flagellar rod.	21.00	21.00	21.10	21.10	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.28	0.72	-3.96	174	1787	2009-01-15 18:05:59	2007-07-31 10:57:32	4	5	1578	0	421	1174	304	49.40	36	20.68	CHANGED	KuMRpus........ps....shh.su..s.sschapsMhDpphApphu.pp.s.GlGLA-hlhcQ	..............................KoMRcu.s.....c-....ulF...su.............p.pschapuMhDpQlAp.pho.pt..t..Gl...GLA-hlhcQ............	0	114	241	325
+9968	PF10136	SpecificRecomb		Site-specific recombinase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4389)	Family	Members of this family of bacterial proteins are found in various putative site-specific recombinase transmembrane proteins.	20.40	20.40	20.70	52.80	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	644	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.14	0.70	-6.48	31	317	2009-01-15 18:05:59	2007-07-31 10:57:55	4	2	305	0	84	286	27	626.70	36	93.99	CHANGED	psshsschthLlcLhcWlR...........stt.ssstp...AhtRlphLlcsL-ppPshpsplpshltsllpphchhsLas-sGlhs+sGFhuElscRltt+lLPssP-ps-ls-LhsllFsctpDspWlsulscpthtRLhpLl..............sstscpph....ssphppsllsAlphLusplsuhGlsP-lhpph.sp...........................shcsoPFhsLpc-stshhsthtptppss...........chspLcshL-pCRsslsplap+hcps..GlSVsLsFpLcRl+ppLtRlctLLsllh.......ssstspthscLhspLlpsspc+pSlptLhssssphLAp+lsEpuucTGEHYITcs+pEYhtMh+uAAGGGhlhAhhshlKhhlsuLtLusFhcGlhsulNYuluFlLIahLHaTlATKQPAMTAsAlAuplcss..scsp...slcphV-.lspllRSQsAAlhGNlhlshPsAlhluhhhthhhGpPhloss+ApthLcols.h.usolhaAAhsGVhLFhSuLIAGahDNhhshc+lsptlthp.hLpthLGtptApRlAsahcpNluulsuNlsLGhhLGhsPslushFGLsLDlRHVshSouslGhAhsslGhpshphsthhhAlsGlslhGhlNlsVSFuLAhhlALRuRslphsstpplh+ulhpRlhppPhsFhhP	.........................t...tpt.phLhtLhpaLR..................sst.pt......sttRlchllpsLcpsPphtsphuphlhthlsphchhsLhscsGlhu+puFhsEhspRlhp+hlPsh.-tspLtplFh.hl.F.sp.sDspWlpslspcphhpLhpLl.............stspppppt....ttphpcphLtAlphLohpluupuLpP-lhphh.sch...........................hpt-SPFlsLp+E...hhthhptht.pspts............................-sspLpVhl-QC+s.lsplp++spps..GsSlplsahLcRLcQpltRlchLlslhs....................tstsp.pthhpLhspLlpAstpppSlppLhcsshphLARploEpsucsGEHYIoRs+pEYhpMhtuAAGGGlllAhhshlKhhls.sh.t.lus.hhpulhsuhNYulGFhlIHhLHaTVATKQPAMTAushAppl-ps.......upst.....sh.p.clspLllslhRSQssAlhGNVhluhPlAhhlshuhsthhttsllssppAthpL+Sls.h.usolhaAAIAGVhLFsSGlIAGahDNhssatpltpRLthp.hL+thhu.tttp+hAsah+cNhuulsGNhhFGhhLGhssslGthhGLPLDIRHVsFSSuslGhAhsshsh......shshhhhulhuVhhIGllNlhVSFuLAlhlALRSRsl+hsph+tLhpslhpplhppPhshFhP..........................	0	19	51	70
+9969	PF10137	TIR-like		Predicted nucleotide-binding protein containing TIR-like domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4271)	Family	Members of this family of bacterial nucleotide-binding proteins contain a TIR-like domain. Their exact function has not, as yet, been defined.	24.70	24.70	29.70	28.30	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.48	0.71	-4.50	28	258	2009-09-11 12:22:46	2007-07-31 10:58:20	4	8	238	0	79	235	14	122.30	31	42.51	CHANGED	+VFIVHG.HD-sAKpcVu+Flc.pLGlcsIILHEQs.spGpTIIEKlEphus.VuFAlVLaTP-DlGsttspts........hp.RARQNVVFEhGahIGKLGRs+VssLl.KG.slEhPsDluGVVYsshDs.s.tuW	.............+lFIlHG.+-p.thtp...p.ltphL.c.p.h.sh.cs.l....lhppps.......st...G....p.T...l...l.E...cl.Ep..t..s....sp....ssFAlllhTPDDhuhhpsptt.............................p.pARpN..VlFEhGhhhG+LGRp..+lhhL......h....cs...sl-..hPSDltGlshhphst.....................................	0	26	54	66
+9970	PF10138	vWA-TerF-like	Tellurium_res;	vWA found in TerF C terminus 	Anantharaman V	anon	Anantharaman V	Domain	vWA domain fused to TerD domain typified by the  TerF protein [1]. Some times found as solos. 	43.40	43.40	43.40	43.50	43.30	43.30	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.19	0.71	-4.49	77	225	2012-10-10 16:07:06	2007-07-31 10:58:34	4	3	174	0	64	274	6	199.20	36	54.93	CHANGED	pA+VsLVLDtSGSMpshY+sGsVQclsERlLulAsphDD....D..Gsl-lahFuschpp...hs............slolsshps.al...........................cph.hs..s.h...........tt.hGt..ss.s.shccV.lspat..............s...ss...........................................PshV....................lFhTDGu..sp.cp.pt.hcchlp..cu..uphPlFWQFVGlGcs.p...............................FshLc+LDs...h...tsRhlD.NusF..Fslccls...plsDtcLY-pLL.sEFPsWlp.......tA+ttsll	................................................AtVsLVLDtSGSM..p...s.....Yp...c.G...s.VQ...p...lh-RllsLA...s...p...hD..D....D.G..plcVahFus...chcp..hs..............slTls.s....hp.s.al..........................pph.pss.....h...h...tthGt..ss.s...slMc-llcaat.pt.........s.ss.......h................................P..s..hVlFlTDGG..s..s..cp.pt..lcchlpcu.....uphPlFWpF....VGlGss.s....................ashLccLDs....h......t..s..RhlDNss..F..Fsh-chs.....plsD...pcLY-pLL.pEF..Wlpts+t.tl.h.......................................	0	14	37	55
+9971	PF10139	Virul_Fac		Putative bacterial virulence factor	COGs, Finn RD, Sammut SJ	anon	COGs (COG4458)	Family	Members of this family of prokaryotic proteins include various putative virulence factor effector proteins. Their exact function is, as yet, unknown.	25.00	25.00	29.00	28.00	18.30	18.10	hmmbuild  -o /dev/null HMM SEED	854	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.33	0.70	-13.22	0.70	-6.61	14	467	2009-01-15 18:05:59	2007-07-31 10:59:05	4	3	251	0	78	343	25	401.00	27	97.56	CHANGED	AI-WlsssRppA.RLspEADuLhhcLRRs+Npu+pLucsutpshslGhFG.SQAGKSaLlSsLAusppGcLpsphs..GcplDFlpclNP...u+EuTGLVTRFo.ppssss.........ssuaPlpLpLloEs-lAKIlsNuaFpDhspppst.hplscppIsshlpphpttppstsssGlos--VlsLhDYhppphspt.p..LpstaWspAhpLAPtLslc-RApLFSlLWGchspLTcsYhphApsLppLupApclhAPLusLV....tt.h.tucuIhsVssLttLsssss..ppltV+PhppGphussVolshApLshLssELhhslsp.st.shhEpVDLLDFPGhRsc.ph.t........t.sssspPluphhlRuKlAYLhERYTspQchssLllCssssppp-VsolutsLcpWlcpTQGEostpRupRpPGLlWAlThaDtRlssphsht............h.......................................................................c-uVpRalucPsc.uWsshLsLs-uGhpRlspaLsphsp.-hKhsRlpEQLsclt+cl..hcshhstaapssssschtcKpphuctlh+sLp...spsth.aGELLctLhssp-plR....pLYhp..............t...sttshssstsss.sstsssshDhFu-sssssss.....s..ss...ttsp-ppaApsVhchWlsHLRpLscsssLlphLGlstpslphLlcELlTuupRLcltppLtpsLtspcps.u.pp-phspRQVhpstslluDFluWLGatplstppR...PsSclpcGptlFstssp..ss.....tpLs+LutpPsstsshYlhDWLVuLtphshcNsGauAupEIospppptLusIL	.................h................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	21	52
+9972	PF10140	YukC	essB;	WXG100 protein secretion system (Wss), protein YukC	COGs, Finn RD, Sammut SJ, Desvaux M	anon	COGs (COG4499)	Family	Members of this family of proteins include predicted membrane proteins homologous to YukC in B. subtilis. The YukC protein family would participate to the formation of a translocon required for the secretion of WXG100 proteins (Pfam:PF06013) in monoderm bacteria, the WXG100 protein secretion system (Wss). This family includes EssB in Staphylococcus aureus.	25.60	25.60	26.10	26.20	24.70	25.50	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.02	0.70	-5.88	16	402	2009-09-10 16:26:00	2007-07-31 10:59:25	4	1	395	1	25	209	0	352.10	39	84.89	CHANGED	php+ucl+hp-hhEhpllcphsPhFhc.plsts-DplhlshpsssphhsFppl+ppscp..pKl+huhs.Vtslpca.ppRlshllpP-NllFscsLpPthlHhGl+-slPPh-hs-EchLpphKshllslhstcasF--.Yhuhh-sh+hoshtKplhpucol-sLhtll.csa.cEp-ppp+shthVPK++a+l.Kalululhslll.hll.llYhhFhtpPhQ-shlpuspsFLsssYocVIosL-chsscphPpsspYpLAhSYlps-p...Ls-pQ+csI.hNslTLpSDcpYhLYWItlGRGph--AL-lA+pL-DspLIhaALsphh-pl+sDssLSGcERpccLcslps-lccY.h+ct	..........................t.lsKSpl+scchc.h..LL-pcusaFls.s.clsp.hcD...o.apIpYclscptps.F.-s..I..+phs+s..EKLRhLhN.ltsL.c.-h..po.RhTFhLtPDpLaFs+sthPhhtpRGlpsllsPhs.l.oEt-FLppYKALlIshFspK.sF-sLhpGsLElt+t..T..sFEppll-AtTL-.LsshL-EpYpKpcpchp.pNhshVpKhtaplFKalAluhssloVLLlshLua.hhF.hh.apE+l..cu.puFlKs.DYo.pVlssh--l-sccLsppuhY.hAhSYIpspK...Lpc-pK-sl.LNNlT.pSsccYLLYWh.lGpGch--AlsIAphLDDsslhhhALhpplpplKsNscLSs-cRscchKcYpccLp-hh-K.t...................................	0	6	12	19
+9973	PF10141	ssDNA-exonuc_C		Single-strand DNA-specific exonuclease, C terminal domain	COGs, Finn RD, Sammut SJ	anon	COGs (COG4199)	Family	Members of this set of prokaryotic domains are found in a set of single-strand DNA-specific exonucleases, including RecJ. Their exact function has not, as yet, been determined.	22.20	22.20	22.50	22.30	21.10	21.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.01	0.71	-4.80	25	1020	2009-01-15 18:05:59	2007-07-31 11:00:12	4	3	1017	0	98	691	27	186.00	30	25.15	CHANGED	QLhDhRoKp......thhtlspshshh.t..tppht...................tpptshpsctlVlhDlPsshspLcplh.p......tpphppIYhhh.pccshYhsGhPoR-pFtphYphlhppscFcl+pchpcLupaLslscchlsFMlpVFhELsF.VoI-sGllslNppspKR-ls-SpsYQp+pcphch-cpLlYuohpElpcWl	........................................................................hs.Rs.p................t..t...hh.................................................t........p.tps....ctl..VlhDlPps.hppLcslh.p......ppphsplYhhh.....phs.....c.....s.hY.l....sGh..soR-pFs+lYKhl...h..p..h...-.h.sl..+p..c..h.ppL..upaLs..lppphLhhMlpVFhELtF..VT..IcD....Gl..lplNp.ps..sKR..sls-SplYQphppplcspchhhhushp-lhsal......................................................	0	23	49	75
+9974	PF10142	PhoPQ_related		PhoPQ-activated pathogenicity-related protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG4287)	Family	Members of this family of bacterial proteins are involved in the virulence of some pathogenic proteobacteria [1].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.14	0.70	-5.98	26	293	2012-10-03 11:45:05	2007-07-31 12:39:29	4	11	226	0	99	405	154	341.20	42	71.85	CHANGED	LssYhpp.tspshpapl..ssstphss.schhhhchTSQpWpspp.sp......WpH.lsIhlPps....shsppALLllssGs.................................t.t.sssssptpsphhttlAppopsslsslsslPNQsLtassp....+cEDshlAaoWptahc....pp-tshPLhlPMstuss+AMchspchhtph.....plcpFlVoGuSKRGWToWLouh.sDpRVtAIsPhVlDhLNhpsslp+hhcsYG.sWshultsYhtpGl......schl.sosthspLhplhDPhpYh.....p+L.slPKallsuosD-FFlsDusphYascLsG..pKtLphlPNssHshhs..ppslpolssFhppl.tpspslP...plphplptsp.....t.tlplpsupt.PppVpLWpAsssss..RDFR	......................................................................................................................LssYhpp.pspshpY.s.....l..h.s..oss.l..st..lhhppapLhSQpWps-s.hV......s.ss...........tWpHpVsIalPcs.......sppccALlllssGh.................................ssphs..st..s..s..-.hs....-...s.L.sslAppTpTlVlsloslPNQhLsFps...Dt.......p....s..............hpED.....-.VuhoWshFhct............sppcthhPLpl...PMspAlspAMclspctLsph...................s.......I..ppF.....lloG.hSKRGWTT.WLoAl..sD......scVc.............AIlPh..sID..l.L.s...h....css...L...cHh....Ypo.YG........N...W...P...l...sFhsY.appGI...................scpl.co..P..s..F..spL.hp.Il....DP.Lp.Yh...........................sRL..slPKYIlNASGD-FFlPD...sopaYascLP..G...s.K.tLRhl.P..Nhs.....H....sls..........phs...po.LlsF....l.s+.h...pp..p.p.........sLP...pl.sh..l..ppph.....................lsVhh..S....Et...PspVhhWoAsNPsu....RDFR..............................................................................................................	0	72	83	92
+9975	PF10143	PhosphMutase		2,3-bisphosphoglycerate-independent phosphoglycerate mutase	COGs, Finn RD, Sammut SJ	anon	COGs (COG4255)	Family	Members of this family are found in various bacterial 2,3-bisphosphoglycerate-independent phosphoglycerate mutase enzymes, which catalyse the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in the reaction: [2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate].	20.50	20.50	20.60	22.30	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.91	0.71	-4.61	92	556	2012-10-03 05:58:16	2007-07-31 12:40:27	4	7	462	6	268	542	95	172.10	32	41.38	CHANGED	AppGhs.GlhcslssGhsPGSDsApLSlhGYD.PtphYsGRGPlEAhuhGlclpss.DlAFRsNhsTl...ccp......................hlhD+pAG+Ips.cEu...ppLhcsLsp..cl...ss..................phpahsusuaRsllVl....+...uss....h...u......spls.sosP..+.hpGp............ltchhPh.....sp.......s...sAcllschhpputclLpsHPlNt	................AppGhsGhhpslssGhsPGSDsApLulhG.YD.Php............hYp.G.RGsLEAhuhGlclpss...Dl.AhRs........NhsTl...cps................................hlhD+pAG.+Iss..EEu...ppLhptLsp....cl....ss.....................sclpF...hsuspaRtllVl.....+.....Gss...................s.......sp..ls..sosP..+..hssp.....................ltphhPh.....st................tut.oAcllschhpcutc.lLp.sHPlN.....................................................................................	1	107	199	243
+9976	PF10144	SMP_2		Bacterial virulence factor haemolysin	COGs, Finn RD, Sammut SJ	anon	COGs (COG3726)	Family	Members of this family of bacterial proteins are membrane proteins that effect the expression of haemolysin under anaerobic conditions [1].	25.50	25.50	25.50	25.80	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.27	0.70	-5.22	5	788	2009-09-14 08:20:40	2007-07-31 12:46:41	4	3	783	0	95	345	12	204.10	52	86.28	CHANGED	MlRAKLKFRLHRTAIlLICLALLVlLMQGASYFSpSHQhARs-QVEELA+TLARQVAaSLSPLM..GscssNup+IsAILcQLTssSRILDASVYppsGoLVA+SGEsVpVRDRLALDGK+uGSYFNaQIVEPIsGKsGPlGFLRlTLDTHsLATEu+QVDNTTNlLRLMILLuLAIGlILARTL....LQsRRoRWQQSPYLLTAspPVKEE-ES	..................Ms+sKLKFRLHRsVI..VLhC.LA.LL.VsL.M.Q.G.AS.a.F.Sp..s...HQ+tR....ssQL.E..E..LARTLA...........RQVsLslAPLM....p..s-o...sD.ccRIpAlLcQLTcESRILDAuVYDcQGcLlA+SGE...o.VpVRDRLA.L...DG.K.+..A....G.u.YFN..Q..Q..IVEP.I....tG..K.N.G.P.LGYLRlTL.D.T.H.s.L.AT.E.u.p.Q.V.DN.T.T.N.IL.....RLML.L.LSLA.I......GVlLTRTL..........LQG+RT...R..W..QQSPaLLTAspPV.EE--.................................	0	5	24	62
+9977	PF10145	PhageMin_Tail		Phage-related minor tail protein	COGs, Finn RD, Sammut SJ	anon	COGs (COG5280)	Family	Members of this family are found in putative phage tail tape measure proteins. 	30.00	30.00	30.00	30.00	29.80	29.40	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.33	0.71	-4.67	185	2672	2009-01-15 18:05:59	2007-07-31 12:56:46	4	25	1759	0	359	2411	301	209.40	19	20.43	CHANGED	lpptshc..hus...p...............h.sh......oss..-hupuhttls..psG....hs.........spphh.shhtsshph.AsAsst..-hspsushhsshhssath.ss.......pp...ssphs.......Dhlstsupp.u.ssshpchupshp.thussupshGhsh.....pphsuhluhhspsGh.puspAGoul+shhtpl.........t..sppstpshpp..........l..G..l................................................................shtc.........upuphpsh.phltplppth.......tt..hsptpp..tshlp..........plF.........................G	..............................................................................................................................................hppthhp..hut..p........h...sh.....oss..-hupuhtths....ptG.......hs..............spphh.....shhtss.hph.....A..t..Assh.......s..h...s.p.s.uph.h....sphhssasl..ss..................cp.......hpplu.....................Dhlstss..sp.s.ss.sh...p...slucshp...thu.......ss.up.sh..Ghsh.......ccsuA.hhuhhtssGh..pustAuo..uh+s.hhtpl.................sts..sc..pstcshp.p..................L....G....l.........................................................................................................................shtc...........spsph...p.s.h.....phltpl....pth.......tt.....hsptpp.....thht.thhG..................................................................................................................................................................................................................................................................................................	0	106	225	302
+9978	PF10146	zf-C4H2		Zinc finger-containing protein 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4451)	Family	This is a family of proteins which appears to have a highly conserved zinc finger domain at the C terminal end, described as -C-X2-CH-X3-H-X5-C-X2-C-. The structure is predicted to contain a coiled coil. Members are annotated as being tumour-associated antigen HCA127 in humans but this could not confirmed.	27.20	27.20	27.70	28.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.83	0.70	-4.33	7	142	2009-01-15 18:05:59	2007-07-31 13:15:50	4	3	99	0	93	126	0	206.40	47	91.22	CHANGED	psItclRsKs.phcKl+sclhcEh-ss-spE+plp-hptph-tL.pEKhuHsEELR.IptDINshEshIKpocs-hp+phphhp+ha-Ehh.l+ttlschhcsh.....LulccL.phcEEE..hlo......................................pA+pshpPp.....hPss..........................PssP...sshhtuhhsstthp.sc...........................tsphc...sh..RpQsPP.......MKsC.SCaQQIHRNAPICPlCKuKSRS+NPKKsKRKp	....................................................................................................tltclRsKTlphEKlKsRlhtEh-shEsEE.+pLcEY+pEM-hLLQEKMuHVEELR.IHADINs......MEssIKQoEs-hs+.hh-ss.pRla.-.EYpPLKcclDth.Rhs......LGLpc..LPsLp...EEE..pp.lo.....-.hap...........................................................pt+t....hps.p................P.................................................................Ps..P......pshtAutssstphpssp.................................................................................p.p.sp..s...sshRQQPPP.........MKuCLSCHQQIHRNAPICPLCKAKSRSRNPKKPK+K...............................................................................................................................	0	35	43	73
+9979	PF10147	CR6_interact		Growth arrest and DNA-damage-inducible proteins-interacting protein 1	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4848)	Family	Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity [1].	21.80	21.80	21.90	22.60	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.55	0.70	-5.02	9	102	2009-01-15 18:05:59	2007-07-31 13:21:45	4	4	86	0	67	101	0	192.60	32	86.81	CHANGED	Mttshhp...pcshh...pLshThs............th..tssp.phhPp+RphhtshhPs.psp...pW.ccs.+YpRchFGRYGht.SGVsPctLaPot.EclcEh.tEchtah.oLppMhcphctpppcccp+tpAREpclAcshtKhPphlAcactphtcpcpctpscKpR+-RLlt-sp-+FGapVDPRssRFpEMLpphEKE-+K+hKttKR+cKcEchhAthsttsup	.............................................................................................t.tt.ph.P..hph.tshhP...ps.....pW.phs.+Ytt+.aGRYGtt.SGVsP.t..h..WPo..Eplc.ch..tE..chtah...oLtpM.cplctppttccp+pptR............EppIAcpMsKMPphltca+pphpc+.............cpctpscKpR+tRLh.tEsp-+hGaplDPRss+FpEhLp..chEKc-+....K+hKttK++tKp.Ethhut.......................	0	22	27	50
+9980	PF10148	SCHIP-1		Schwannomin-interacting protein 1	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4847)	Family	Members of this family are coiled coil protein involved in linking membrane proteins to the cytoskeleton.	21.70	21.70	21.80	23.70	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.54	0.70	-4.97	2	132	2009-01-15 18:05:59	2007-07-31 13:44:20	4	8	75	0	80	130	0	206.90	59	57.02	CHANGED	shpAQ+NERESIRQKLALGSFaDDG.hhaTuCSKSGKssLSSRLQsGhNLQhCFVNDSuSD+DSDA-DS+TETSLDTPLSPMSKQSSShSDRDTsEE-.-S.-D.-FhphQ++LQtEA+hALAhA+PMA+MQVEVE+Q.p..++SPVADLLPHhPHISECLMKRsL+PsDhRDMolGQLQVIsNDLHSQIpuLNEELVQLLLhRDELHhEQDAMLVDlEDLTRHAcSQQ+HMhEK..uK	....................................................................................................AQ+NERESIRQKLALGS......F.a.....D....DsPslYTosS.+uGKPS..LSS.RLQSGMNLQICFVND.S.uS...D.....KD.S.....DADD.....S.....+..T............ETS.L..D..T..P...L......SP.......MSKQSS..Sh...S..D.R.DToE--.S.....ES..L-Dh.D...F.loRQ....+KL.Qu...EA+hALAhAKP.MAKMQVEVEKQNR......K.KSPVADL...L...P.H...M...PH..I.S..ECL..M..KRsL.+...ssD...LRDMTlGQLQVIVNDLHSQIESLNEELVQLLLhRDELHhEQDAMLVDIEDLTRHs..pupQ++.t-+...................	0	21	28	62
+9981	PF10149	TM231	NAcGluc_Transf;	Transmembrane protein 231	KOGs, Finn RD, Sammut SJ	anon	KOGs (KOG4838)	Family	This is a family of transmembrane proteins, given the number 231, of unknown function. It is conserved in eukaryotes.	20.50	20.50	22.90	21.10	18.10	20.30	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.89	0.70	-5.44	7	132	2009-01-15 18:05:59	2007-07-31 14:10:04	4	6	95	0	88	132	1	236.80	31	81.00	CHANGED	Mthaslas+sshlhY+spLCShAoLhlhhhlhLohh.P..LlshhpshuhW.cppshhEQPsVpFpYphlhluph-s.......stuhlAhSoFssFN.pLpsps.psstlpshpEDsNhDGppDtLphpl..pLP.pso.plhthpLllhF-hpLpphsshsh.ohhslphp.P.....hhuupl.hpG-LpLpQ....psPhshRslcopas.Vpl.hNuoss.hspaphcsIhtph.ctNsuha.hsspph.Wphspuuts..h.lchtl...ch.p.slhY+suhWpplt.hWlpYhSlLhI.Lalhp+lKpFlFpppllpohpl.lPaKc	.....................................................h.hatpsh...h.Y.st.hohuslhhhhhhhhthh.P..llhhhpstGhWh+pssa.EQPsVpFpaphlhls.hs.........tthlshSo.a.sth..N.phtss.p...h.......ph.s.......hl...phh.........p......pDh.NtDG....ph..Dhlphpl..pl.shpst..plhthpll..hhFphpLpphsph.hpohhhhp...t.s......h.supl.h.G-LpLpQ....pts.h..ts....h.....p...a..........p.hpl.hstst...h.p.......aph...pplhtth.ptN.shh..t....h...ah.s....s.t.ts...h.lph.l..........ph..........h.............Y.....suhWEhlK.hWlQYhuhhhlhhalhpclp.alFppplltoh.........................................	0	31	40	66
+9982	PF10150	RNase_E_G		Ribonuclease E/G family	Bateman A	anon	Pfam-B_234 (Release 21.0)	Family	Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs [1].	22.70	22.70	22.70	23.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.64	0.70	-5.17	173	4570	2009-01-15 18:05:59	2007-07-31 16:14:19	4	14	3079	16	1101	3529	3482	263.90	41	37.13	CHANGED	olsGRYlVlhP.......pssp..lGlS++Icsc..p-Rc+L+....plh.........................ppl...hsps.......hGlIlRTuupssspcclppDlphLhchWppIpcc.tpptt...........PsLlac-.slhh+slRDhhssclpclllDs....ppsapphppa.h..pphhPph.hp..pl..phap....sp.tslFctaslEppIpcsh.p++V.Lt...SGGallI-pTEALssIDVNoGph.sspps..h--Tsh+TNlEAAcEIARQLRLRslGGlIlIDFIDMpspccccpVhctLccslcpD+s+splssho.pLGLlEhTRKRhR	.............................................................................SLsGRYLVhMP.......sss+..sGlS++I...-s-.ERpcLKchl...............................tpl.....hs.cs.................hGlIlRTAu....t.Gtst.--LptDlsaLh+hW.ppIpcp....tp..p...tt...s..............................PhLlapEss.lhh.RslR...Dh.h.s.p.-...lscIllDs...................ppsa.cphp.pa.h...p.h...hPch...ss.................+l...chY.p..............sc...hPlFstaplEspIpp..Ah..pRcVpL.....SGGhllIDpTEAhTsIDlNoGph...st.t..............t..s.............lE..-Tsh.pTNLEAAcEIARQLRLRsLGGlI.lIDFIDMs.stccp+tV.pp....Lc....cALpp.D.Rs+h.plstlS.phGLlEMoRpRh.......................................................................	0	343	700	917
+9983	PF10151	DUF2359		Uncharacterised conserved protein (DUF2359)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4467)	Family	This is a 450 amino acid region of a family of proteins conserved from insects to humans. The mouse protein, Q8BM55, is annotated as being a putative Vitamin K-dependent carboxylation gamma-carboxyglutamic (GLA) domain containing protein, but this could not be confirmed. The function is not known.	19.80	19.80	20.00	20.90	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.50	0.70	-5.97	6	158	2009-01-15 18:05:59	2007-08-01 11:58:53	4	5	88	0	99	172	0	346.60	30	64.08	CHANGED	HGYRlCIQAlLQDKPKIsTsNLscaLELLRS+QsRPhKCLTIMWALGQAGFssLopGL+VWLGIMLPVLGlKuLSsYAIAYL-RLLLhHsNLTKGF.GhlGPKDFFPLLDFAaMPNNuL.................................SsSLQEQLppLYPRLKVLAFGAKPESTLHTYFPSFLSRA.TPuCPs-MKKELLsSLT-CLsVDshShSVWRQLYsKHLuQSSLLLpHLL+oWcplPpKhpK.SLp-TlQSF+VTNpEh.tKGuuusp-lpsCsoACpuL.pKh+GsuhPWsRLLL.lLLVFslGFlsHDlRoHuSFQuSpTuphLppSGlhssuQQAhu+lpsYShQG.SWLpcshPtahSchlpVltPshp.uhs+hptsssFlst+stshlsahp-plsphhphl.tphP-sl.QhhthL+ELLLhhh+shlLPshthLhtsltth.pph.tuCpGcVohsClpspl.phup.oWhhLQcsTsshhs.tluh	.............................................................hlh...Pphh...h...h.....psh..pp....hhl.slhWsluQAuhssLs.GLplWhtlhLPlL............s.....hK.....s.....h..u.....s.....hs....l....t.hl.-........Rl........L.....................hps........s........l.....p........c.u...........t....hlsPppFhsl...hc.hsa....s..p..ssh.................................s..shp-phptlYPpLK...luhu.u.ps..to......p....h.....pp...h..h.p....h..h...s...cu...ssps....s....s...p..h.....pcEh.h.s.shh..CLs...s..s..shphWcp.LY.cpLptS.....shLLp+LhpsWcphs.tKh.....p..p......s......L.pcTlpSh+hpNpch..hp..cu..p..s...ppp....sl....hs....s.......cthCc.....slhtp.............h.......p...u........t...........h..hsp.........h..hl...hllhhhs..G.hlhaD..h..t.t..s...httS.st.hLppsG.....hh.h.ppsh.hh..h..tu.phht...s.h............t.............ht........................h.....................................................................................................................................................................................................................	0	23	39	65
+9984	PF10152	DUF2360		Predicted coiled-coil domain-containing protein (DUF2360)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4496)	Family	This is the conserved 140 amino acid region of a family of proteins conserved from nematodes to humans. One C. elegans member is annotated as a Daf-16-dependent longevity protein 1 but this could not be confirmed. The function is unknown.	24.30	24.30	24.60	24.30	24.00	24.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.79	0.71	-3.92	22	332	2009-09-14 15:15:59	2007-08-01 13:41:33	4	33	124	0	252	294	3	108.90	26	34.36	CHANGED	lNpFllpTlpFLNRFushCEsKLsphppplQplEtphtlLEsKL...uSIs...................Ghppl.............................................sssssssssppsss.sssss................t.stssusssptsshtsss..t.................P.h...shhphp..pDPRYttYaKMLplsVPstAl+sKMpt-Gl-PshLDs	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s......t......s.hhthp....c-PcY.sKYFKMl.ph.GlPhtul+tKMht-..G..lDsslL-.............................................................................................................................................	0	124	163	225
+9985	PF10153	DUF2361		Uncharacterised conserved protein (DUF2361)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4484)	Family	This is a region of 120 amino acids that is conserved in a family of proteins found from plants to fungi. The function is not known.	25.00	25.00	28.70	25.50	19.50	21.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.46	0.71	-3.89	28	193	2009-09-10 22:45:35	2007-08-01 13:50:37	4	4	165	0	142	189	2	111.10	35	37.80	CHANGED	clK++IRDlERLLp+c...sLPsclRl-pERsLpuL+hcLps..pptcppp+Kh...hcKYHhVRFFERKKApRclKpLcKphcps.s...........tttchcphpcpLcpsclDLsYVlhFP+sEKYISLY	........................lKp+IR..slcRLLp+p......sLPsslRlppERpLpuLcpplpp....pptppt....cpph.......hpK....YHhV......RFF...........ER+KspRpl+pLp+phcpsp...............................tttph.pplppplpttclDLsYsh..........aaPpsEKYlSLa.........................................	0	44	84	122
+9986	PF10154	DUF2362		Uncharacterized conserved protein (DUF2362)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4506)	Family	This is a family of proteins conserved from nematodes to humans. The function is not known.	25.00	25.00	27.60	27.60	22.80	22.30	hmmbuild  -o /dev/null HMM SEED	510	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.65	0.70	-5.83	7	140	2009-01-15 18:05:59	2007-08-01 14:11:51	4	4	99	0	101	136	2	381.70	37	82.64	CHANGED	ppshscLptplhhl+t...Pph....h-psLcpsLppFl-p..EslschDccAEthlpthtptcs-hptlspsht+hYs-phLEaAc..tss.-EpFApsaHpLlHSss.pplLshE+sYhhslophhpcpD.Elcphpphpt.EhsK.hppLstolsspDlN.shhAppapsQp.lcp+auoELpphpshQKpEYpcWV...........sSpls-phpsQstp.ptsustsshh.ppppphEESFTIHLGuQLKpMHNlRLlpsc.hhDhCp....hcscto..phpRLphAhuLYSoSLCGlVLLlssp...hss.c+-FhpssppsT-FHFspl-cQLEhlppsl..L.sptp+sphpctp.spsspstusts+sc..........+p.sslhsG-FaITRHSNLScsHVlFHLslD-slpS.....upIsuRcPsIhGLRNILKssspHDITTIoIPlLLhH.-MSE-MTlsWCl+RAELVFKCsKGFMhEhsSWsGu.....pTVQFLlPpsISEphFhpLusMlPplF+VusshhL	.....................................................................pl..ptLppFlpp..pp.p..scpsp..lpth.t..ptp.sl.pthhptht+.atpp........hlpasc....ts.....s...............--....FutsaHpLlHS..s...s.cslLphEptahhsls-hhtttc.plpphp.pp..............p..........t.EhpphhppL.......shshosp-lN.slhupp..hpppp...............l..cppapsclct.pthQ+pEYppWl.th.t..............ss...th.......sp........h.....h.p..s.....................p......s....pt......t....pp....t...........h-ESFTIa...L..G.uQLKpMHNlRllpss..hh-hCp.................hpspts...........pRLphAhuLYSssLsGlVLLs.......s.......s.p.......hsshpc...........phhphsppsT-FHFspl-pQL.chlpp.h......h...t.p......pth.ppt........p.ttttt.................................................pp..pl.....s.G-haIT+HSNLu...........p.....h.HVhFHLssD-.s.lpS.....spIsuRcPslhGLRNIL+ss.spaDloTloIPlLLhc..-...hsE.....cMTl...s....W........Cl+RAELVF..............KClKGFhhE..soh....sus...........polQhllPpslo..cphFhplsshlPplF+lsssh.............................	0	46	53	81
+9987	PF10155	DUF2363		Uncharacterized conserved protein (DUF2363)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4508)	Family	This is a region of 120 amino acids of a family of proteins conserved from plants to humans.  The function is not known.	25.00	25.00	26.80	26.90	21.90	19.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.55	0.71	-4.20	16	204	2009-01-15 18:05:59	2007-08-01 14:17:11	4	3	134	0	149	197	3	120.10	58	30.15	CHANGED	lEpNPplAh-lLh+lhpos.p........hp-YhcsLlsh-lolpShElVN+Loppl.......pLPp-FlphYIspCIpsCpslK..-+.hQsRhVRLVsVFlpoLI+sKllss..+-LhsElpuFClEFS+lpEAssLF+hlKs	............VEsNPllAlEhLlKLhpSs..p........................Is-YFslLVs..M-MSLHSMEVVN..RLTTuV..............-LPsEFlHhYISNCIuoCEp.lK.........DKYMQNRLVRLVCVFLQSLIRN.KIINV....pD...LFIEV........Q.......AFC..lEFS..R..IREAAuLFRLLK..........................	0	71	93	123
+9988	PF10156	Med17	DUF2364; 	Subunit 17 of Mediator complex	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4512)	Family	This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.	19.40	19.40	19.40	19.40	19.30	19.30	hmmbuild  -o /dev/null HMM SEED	467	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.42	0.70	-6.22	28	294	2009-01-15 18:05:59	2007-08-01 16:06:26	4	5	238	3	216	270	0	390.00	21	67.52	CHANGED	Ms...............psh.lsLcP.....................tt..pp...........s..................................lslcphIspIhtEhG...sFtslsEcoLpccIppppsptptsptspp...........ppccspssp................................................................ppsph-ph.pt..+p-lhpplppAhsEssluLDFlSLLlSphpsp......................uhsohS.....PhLcphsPsuSLs...u-hlt.s..ttpttht...............ptlspGWKhcuLspAsshLhpuup+Lppplpp...........Epc.................................................................YWpcllplppps.....Wtlh......+h...tpspp.lGlcYGat-uGspF.+ccGlAsLRpssc.uslpl................s..........shthpts+hlRV+Ih......csthlsGp.Sphs........p.tssssslpspIppA+pslFEcELFapLpREAppLhshslplps..Nplhhpls.......sppltI-L..........lsh-cps.tstpt........sp.psthApslhtsL+lLLsthH+psLpp+tpsssshs.h.....................p.p.sss.hlLRPlluhh+Hpphhphhpphlsslspslpsss	............................................................................................................................t...................................................................................................................................hslpt.htp..tphu...t.h.lt..shpppltp.ttp..s...tptttp............pppptttt......................................................................................tpptt.c....ph......hp..plh...pplp.......pAhsEhslhhDhl.Sllhsp..................................................................................................thhshs..............Ph.pp.....hs....tphs..................................................................thlphhhKhcuLst..uuphLhpuAp.cLpppltp....................ppc.................................................................aapcllplppp......Wplp............................phts.lh.sc..h...u...a...tpu..u.sha.pptshtsh+psp......tshth..........................................................................s...hpt..thlp...Vpl.........tsh.hss...pt.............................p.t.ts...p.hppp....lptA.......p.......pslhpcElFtpLsREAhplh.s.....h...sph...h....stlhhph..........s...pl.lpL............................h...sptt.tt.t.................................pths.hl.h.L+.L.lt.hactp.pph...s.ss.s.h....................................p.p.p.....lLc.llt.hpH..hhp...htthlpphst.l.........................................................................................................................................................................................................................................................................................	0	70	116	175
+9989	PF10157	DUF2365		Uncharacterized conserved protein (DUF2365)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4514)	Family	This is a family of conserved proteins found from nematodes to humans. The function is unknown.	26.20	26.20	26.30	27.30	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.77	0.71	-4.32	6	109	2009-01-15 18:05:59	2007-08-01 16:13:18	4	5	96	0	81	116	0	135.70	33	51.13	CHANGED	csGchTHFVAcNLEtKIR...............pSucpo.TPssusGPh........hsht.h.p...IP.....lDPsVLsDlEpcuQtLAsSVDsLLcsLsusLHulSulTs-slpsY+sAVsKLsDslDuNIKshYsLLAKsEEls+SMpPscpLAppIR-IKRLVDhLEolh	.................................................t..st.h.FlspsLp.+l+...........................s.........s.......ts.tsh.......................t.h..p.t.lP.....lDss.lLp-LEpcupplussVDpLhcsLsuslpp.houlolsslpsa+cuVspls-.u.l.DtsIKu......hYpLlA+sEELs+uMpslptLAppl+cI++hl-hh-sh..............	0	32	41	65
+9990	PF10158	LOH1CR12		Tumour suppressor protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4515)	Family	This is a region of 130 amino acids that is the most conserved region of hypothetical proteins involved in loss of heterozygosity and thus tumour suppression [1]. The exact function is not known.	23.20	23.20	23.30	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.62	0.71	-4.36	5	152	2009-01-15 18:05:59	2007-08-01 17:47:16	4	5	94	0	69	138	0	104.40	47	44.96	CHANGED	pFLPVL+GlLSupTs.pTNp....pLERLcSppllpLCoRhQ-HLspCAcAVAuDQNpLVcRIKEVDsSlsoLauthp-+QKpYAuYAEQluKVNplSspLsRIQhlL-QsVPhMEpLNshLs--ERLEPFsh..................+P-	..............................pF.PlL+tslout...Ts....s.sp.....hLE+....LsSppllplChRhQs....HLp.CAphVA....-QstLstphKph-.thtpl.....ht.h.ptpcpaspasp.pht+...lpphpt.lpchp................hlpp.l..h-tlNphLs.tcpL..hsh........................	0	22	27	50
+9991	PF10159	MMtag		Kinase phosphorylation protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4520)	Domain	This is a glycine-rich domain that is the most highly conserved region of a family of proteins that in vertebrates are associated with tumours in multiple myelomas. The region may contain phosphorylation sites for several protein kinases, as well as N-myristoylation sites and nuclear localisation signals, so it might act as a signal molecule in the nucleus [1].	25.00	25.00	26.40	25.10	24.60	21.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.83	0.72	-3.94	16	182	2009-01-15 18:05:59	2007-08-01 18:10:29	4	5	163	0	133	175	1	77.70	55	27.33	CHANGED	GsRGGpspFpW-DV+ssp..cR................ENYLGHSlh.APVGRWpKG+DLpWYsK..scsssuptst........ph+EElp+lKptEpcAhttALG	.........GsRGGpspFpW-DVKs..sp..cR................ENYLGHSLh.APVGR.WQKG+DLsWYAK.........scss....s.s..s..t....................pccEElpclKcAEc-AhttALG.............................................	0	46	76	103
+9992	PF10160	Tmemb_40	Tmem40; 	Predicted membrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4536)	Family	This is a region of 280 amino acids from a group of proteins conserved from plants to humans. It is predicted to be a membrane protein but its function is otherwise unknown.	25.00	25.00	25.10	36.70	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.87	0.70	-5.16	7	145	2009-01-15 18:05:59	2007-08-02 10:45:22	4	3	83	0	90	124	1	232.70	37	73.71	CHANGED	hc.luss+sphashlLllPslhFhhFLhachspuhsKLphspS..IhluaYhLlalVullslhhshlphh.shsst......pshWpllphF....hLhlElSllhFhLthsahsutpSlpRshllouhlshh.slsQshhphths..hsLhhs..s..pcGththWlhpphlhhhVYhhlhhh..hp.phR.+LPu+suFY.YhhhhhhLNhlphhusuLhsspst.GhhhhsloshhYaulahPLlYlTFLtcFhpp.....................D..L.ssahu	.........................lsps+shhaslhLllPslLFhlFLhh+h.puhtKlp....hspS..IhloaYhLlalVullslshshlph.h..sssst......cllWplhphF....hLslElSllhhh.Lthu..al.p...utpSlpRsLhlosl.....luhs.olhpuhh.hhas.....s.L.h..c.....s...h....s.hh.sc....GthtaWlhpphhhhhVYshlhhh...h..+.R..p..LP...............u+.uFYhYsshhhhLNhlphhGssLls.h.s.hh...Ghh.hhshTshhYauhahPLl.YhsFLtsFFtpp....................c..L..............................................	0	22	42	68
+9993	PF10161	DDDD		Putative mitochondrial precursor protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4542)	Family	This is a family of small conserved proteins found from nematodes to humans. The C-terminal region is rich in asparagine. Members are putatively assigned to be mitochondrial precursor proteins but this could not be confirmed.	21.00	21.00	23.40	22.30	20.90	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.53	0.72	-4.35	9	96	2009-01-15 18:05:59	2007-08-02 11:08:41	4	4	78	0	69	85	0	76.30	44	71.82	CHANGED	ssphustssshulh.h.hposhshpSGAltP+PpphsFGLLtlhhsVIPuLaIGuhISKNhAsaLEENDlFVPsDDDDDD	.............................ts..............h..RoshsspSGA..lhP+P..chsFGLL+l...........hslVI...Ph..LalGshISKNhAshLEEpDIFVP-DDDDDD.............	0	19	23	47
+9994	PF10162	G8		G8 domain	He Q, Liu X, Bateman A	anon	He Q, Liu X	Domain	This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.	21.00	21.00	21.10	22.90	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.55	0.71	-4.33	34	504	2009-01-15 18:05:59	2007-08-02 11:58:43	4	98	97	0	317	448	35	124.80	30	7.75	CHANGED	soWtst.....pl.........Pps..ucsVhIssGpplllDss....ss.hpplhl........pGpLlFss.....pshsLpspsIhlpsG..plphGoppsPa.....psphsIsLpG.........................spsssph.......shGsKsIulhtsGsl-lHG...............csoWTcLss	...................................................Wt.st.................Pp..s..uspVhI..pGphlllDss.....sshhphlhl......sG...pLlFs-................pslpLps.c.hIllpsG................u.pLplG.o...cpsPa.....................ps..chpIsLhG...................................................................pts.ssph.................sshGsK..s.lu..........Vht.GsL-LHG...............hphs.WTpLs.t....................................................................................	0	146	187	233
+9995	PF10163	EnY2		Transcription factor e(y)2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4479)	Family	EnY2 is a small transcription factor which is combined in a complex with the TAFII40 protein [1]. The protein is conserved from paramecium to humans.	20.50	20.50	20.80	20.70	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.71	0.72	-4.05	24	256	2009-01-15 18:05:59	2007-08-02 12:50:33	4	9	183	24	181	241	1	83.10	35	66.19	CHANGED	plcstlppp...LlpS..G-pc+lpchL+t+LhEsGWpDcl+phs+chlpp...............tt.sslsh-cLhshlsP+AcshVP-pVKp-lLp+I+saLs	...................hpstlppc...Llco..G-p-+Lc-LL.+p+L..h....EC.GW+Dpl+ths+.chlcc...................puhp..sloh--LlsplsP+uRs.hVP-sVKpE.LLp+I+saL.h............................................................	0	67	94	144
+9996	PF10164	DUF2367		Uncharacterized conserved protein (DUF2367)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4517)	Family	This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. The function is unknown. Several members are putatively assigned as brain protein i3 but this was not validated.	22.00	22.00	24.00	23.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.38	0.72	-4.15	4	109	2009-09-11 06:36:34	2007-08-02 13:25:12	4	1	77	0	78	100	0	88.90	38	74.20	CHANGED	hPsYGAh-ous.tsPlPlV....lpssPsutPph............hsp.IIVVGGCPsCRIGhLEDsaoChGIhCAIFFFPlGILCCLAh+pRRCoNCGs.F	.........................................................................................................s..............s.......t..........................sp..llVl..G......G.CPsCRlGsL.E..Ds.F.TsLGIhh...AIhhFPlGll.....CChuh...Rp+RCsNCGAhF.............	0	35	40	62
+9997	PF10165	Ric8		Guanine nucleotide exchange factor synembryn	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4464)	Family	Ric8 is involved in the EGL-30 neurotransmitter signalling pathway [1]. It is a guanine nucleotide exchange factor [2] that regulates neurotransmitter secretion.	25.30	25.30	28.10	26.00	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	446	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.60	0.70	-5.66	23	341	2009-01-15 18:05:59	2007-08-02 14:02:37	4	3	198	0	221	310	0	380.40	31	83.45	CHANGED	sLpsl+lluR-hpshsPhhocculph.LhpaAth...................................................................................................................psss.csthEALKCLsNhlh.sspsp..phhschthsstlscpLpps.t..................sp-scahthRLlFLhTu.sststppLhpchpslshlsttLppphpptspstpt....................-t.tlsEsLKllFNlThhhscpts.............p.uspht+lsslLpcl..................shsps.h-shhuphlNhLssL.sLpshcs.....hppssl................................tssshsslctLlphL-pplpph................pshc...............-plsPlLslLschschs...............................ctsR+al+ttlLPs...cDhcp...t.-pusoLpu+LlRLhTps..sslKcsuuEhLFVLCpcsss+hlKhsGYG.AAGlLAsRGl..sh......tp..t...............tauss.pcu-T--.............hpphp.sINPlTGph.s.-p....ssh-s...MT-EpKEtEA.+LhsLF-....+hpcpGllps.............tthhp-G+	..........................................................................hLptl+lhuR-.p.shsshhscps........hph.Lhphu.................................................................................................................................p......p...shhEuL+CLsNhlh.s..sp.........phhh..-h.t.hs....t.l..sphlpt.........................................sp-.p..hh.shRlLFLho..hhpst.h.hppLhpch..phhph..lsphl..pttht.....hh.ttt.t.....................................pp.thhEhLKhlFNlTh...c.t..............................p.stth.hlhslLpch..................s.stp.hpth.hsphlNhLssl.slp.shc..s................ptt.s.h.........................................................................................................................s.shpslphLlphh-pplpph......................................pt.c.......................ptlsPlLslLpchscht...............................cthR+al+......t........p........lLPs...cDh..pp.......................h.p..h..us..s..lps+LlRLhTpss..sl+phsuEhLFl..L...C.......pcs........s...sphlKhsGYGsAAGhLss+Gl.....sh.......tp.....t............................aSp...p.psoco--..............htphp...tlNPl.TGph.p...........ssh.t....MT-EpKEhEA.+Lhshh-....+Lppptll.p.s..................................................................	0	72	106	168
+9998	PF10166	DUF2368		Uncharacterised conserved protein (DUF2368)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4544)	Family	This family is conserved from nematodes to humans. The function is not known.	25.00	25.00	34.70	34.50	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.77	0.71	-4.54	13	98	2009-01-15 18:05:59	2007-08-02 14:20:32	4	2	76	0	72	84	0	127.10	39	88.52	CHANGED	MGt..shu+u.p.pNh+cpQEa.....chQhERQLtMppph+pRQhAhplApuREhhpW..huuFaslssluhssuhhK+K.......+PshlsPllPLuFlluYQhDhuYGsplpRl+uEAEpIl-pEpp.LLphPtGh.TlcsI-c	...................G...hhscs.s...tsh+p.pQ...Eh..........chQhERQlhMQspMRERphAhp..IAhuREhhpa..husFaulAsluhsuuuh+.pK.......+s.shlhPllPLoFllsY...QhDhuYGohlpRh+uEAEpIhcpEpp..hLphPtGh.Thpsl-p......................	0	28	32	53
+9999	PF10167	NEP		Uncharacterised conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4523)	Family	This is the N-terminal 80 residues of a family of proteins conserved from plants to humans. It contains a characteristic NEP sequence motif. The function is not known.	25.00	25.00	27.60	26.20	23.40	24.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.41	0.71	-4.40	7	127	2009-01-15 18:05:59	2007-08-02 14:45:11	4	2	98	0	89	113	0	107.90	33	64.56	CHANGED	hp-sEhth+h++so-KhoEslahlANEPSluLYRlQEHVR+slPpllp++s-lhphppphpGtsYDlEYuhpsVKohpc.....us.hFpsIpphL+puIthKpplpss..pu+p..cpptsssSs	..........................ph..thtc...so-+hoEslhllANEPSlALYRlQEHlR+ulPtlspc+schtphppp.pGthaslEYuhsAV+shtc.....us.hFcslpphL+puIth+pphpht...ps..............s..................................	0	30	46	69
+10000	PF10168	Nup88		Nuclear pore component	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4460)	Family	Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain [1]. Nup88 is overexpressed in tumour cells [2].	20.00	20.00	20.00	20.00	19.60	19.90	hmmbuild  -o /dev/null HMM SEED	717	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.39	0.70	-13.25	0.70	-6.69	5	211	2009-01-15 18:05:59	2007-08-02 14:58:37	4	6	126	0	142	223	0	392.10	22	73.25	CHANGED	G-pWpppLscHcLFs+L+EGL+lppcTppct.t................+NLLsCLDG-LFlWDucESsFLVsNLRSssusuppsshSpYQTLLCoNPPLFEVscVLlSPoQaHVALlGsRGVsILELP+RWGKcSEFEGGKpsINCRThPlAERlFTSSsSLsLRQAtWYPSEspEPHLlLLTSDNTIRlYNLp-PpoPs+VssLSph.c-osl+ssupoatASLGETAVAFDFGP..............................LussPKsLsGp+..uKpEhlsYPLYILYENGETYLlYISL.+psuslGKLhGPLsMaPuAEDNYGYDACAVLCLPCVPNIIVIATESGhLYHCVVLEAEE-E-touNEsWDuss-psPSLY..VFECVELELuLKLAosE-E.h.-sDFoCPI+L+RDPICppRYHCTHsAGVHSVGLoWIs+LcKFL-S-EEDKDSLQELAoEQ+ChVEHILCTKPLsscpPuPVpGFWIlsDl.LGAoMICITuoaECIuLPLLool+PsSPPLLCo+hDs-Vspp..+hLAEossSFEcHIRoILQRSVsNPlLLpSu-KDSSPPPcECLQLLSRATQVFREQYLLKpDLA+EEhQRRVKLLpsQKEKQLEDlphCREERKSLoEsAE+LAEKFEEAK-+QEsLlNRsK+lLpSh+oQLPVLS-SERDM+KELQpIs-QL+HLuNuIcQVK+KhsYQ+++Ms.uscSP+KsolTLs-+Q+KsIpsILKEpGEHIccMlKQIKcI+NHVuF	......................................................................................................................................................................................................................................................................................................................................................................l.ph.WaP.....tsphh..hL.sps.hc.aph.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	64	88	117
+10001	PF10169	Laps		Learning-associated protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4811)	Family	This is a family of 121-amino acid secretory proteins. Laps functions in the regulation of neuronal cell adhesion and/or movement and synapse attachment [1]. Laps binds to the ApC/EBP (Aplysia CCAAT/enhancer binding protein) promoter and activates the transcription of ApC/EBP mRNA [2].	25.70	25.70	26.10	25.80	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.24	0.71	-3.90	11	105	2009-01-15 18:05:59	2007-08-02 16:02:28	4	5	86	0	69	106	0	123.20	42	88.89	CHANGED	KSLRSKa+R.KMRA.KRpKstPKELtRLKpsLu.p-....ut.lMc-lp-lsphhsscchc.Eptct-sp.......t.....pcctKM-V-sc...h....NpKTLpDpaGpYPsWhNpRQ.pKKh+tKppupK.sKsKs.....sKsls	.............KSLRSKWKR.KMRA.KRcKsAPKELsRLKphLt.hD.....uchl.MpDlp....-IATVlss+chc..cphph-tp.............ppt.....pcstKM-.s-tK...+....N+K..TLhD..paGpYPlWMspRQ.tK+LKsK+pppK..s+s+s..sh..th.....................	0	17	23	46
+10002	PF10170	C6_DPF		Cysteine-rich domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4543)	Domain	This is the N-terminal approximately 100 amino acids of a family of proteins found from nematodes to humans. It contains between six and eight highly conserved cysteine residues and a characteristic DPF sequence motif. One member is putatively named as receptor for egg jelly protein but this could not confirmed.	20.70	20.70	21.10	36.90	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.45	0.72	-3.93	8	86	2009-01-15 18:05:59	2007-08-02 16:22:26	4	3	73	0	60	75	0	90.60	44	66.03	CHANGED	FcCQLCsLouPYoYaGQKPPsopulVLLE-sYVMKDPF.......oPD+E+FLlLGS+CSlCSKsVCVGs-CSLFYoKRFCLPCVpcplpsFP.EIQp-l-K+K	..........................FpCplCslpt.apY.hGp......+PP.....s.pullhLE-sYVM+DPF..........................o.s.c+ccaLlLGucCSlCu+hVClus........pCSlFYo+RFChsCsppphptFP.clptclpK...............................	0	16	20	40
+10003	PF10171	DUF2366		Uncharacterised conserved protein (DUF2366)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4545)	Family	This is a family of proteins conserved from nematodes to humans. The function is not known.	25.00	25.00	35.20	30.50	17.90	16.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.78	0.71	-4.77	9	94	2009-01-15 18:05:59	2007-08-02 16:30:53	4	3	80	0	68	89	0	155.90	36	75.42	CHANGED	sshthPp+acphh.pKhuhaa+uLlpDYpEssh-sspsu+sRPhKAulYLolLushhhsstpNPsEssF.spLhcssspLlLVsPpppNssSstalppL.chhNpG+LR+lSLGlhSllahssaDcssslYpAhC.alps.tahshacRllDVGFhG+WWhLcpKMhDYDlNp-	..................h......thatth.....stah+sLhpDYt-ssh-ssttspt+Ph+AslYsshLuushhshtpsPsEtsFpp.tLlcsospLlLlusthRN.pSptalppL.hhhspGpLRalsLGlhSLla.ssaDtpsslYpApCpYLps.pahsF.pRllDVGFhG+WWlLpt+McDaDlNp.......	0	27	31	52
+10004	PF10172	DDA1		Det1 complexing ubiquitin ligase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4816)	Family	DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system [1].	21.00	21.00	21.20	21.30	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.18	0.72	-4.15	11	148	2009-01-15 18:05:59	2007-08-02 17:01:35	4	2	101	0	93	145	0	62.20	44	51.23	CHANGED	cFLpsLPs.sppNFS.h..ssss.psostRssVYlPT..cshP.s-QlIsT-ppNILlRaLpQph-cK	................cFLpGLPsascuNFSphpss...sss..ps....SspcsuV...YlPT..cshP.............s-Ql...IsT-p.TNILLRaLpQph-KK..........	0	23	46	72
+10005	PF10173	Mit_KHE1	DUF2343;	Mitochondrial K+-H+ exchange-related	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4539)	Family	The members of this family function as mitochondrial potassium-hydrogen exchange transporters. The family is part of a large mitochondrial KHE protein complex.	22.50	22.50	24.30	25.20	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.38	0.71	-4.44	47	180	2009-01-15 18:05:59	2007-08-03 11:32:18	4	3	162	0	133	170	3	185.80	32	61.97	CHANGED	+lhl..lPlos...........+.+s.........hlY..spphp...t....................................phhphhs+lssKAucs....Wsphppucpu....a....pp+llsaGp+lLp+lPaEEhuLKSl.....Pshsp.h+phpp..........................................................ttp..........plplhaP....sslpspplhspL.+plupcptthH++hhhhshlshPlThPhsLlPllPNlPhFYlsYRuauHa+AhpGucHLphLlc	..................................RlhllPlos.................+.+s.....hlY..spphssh.h....................................tpt.shhctlssKuucs....WsphccupcG....a....p++lssaGp+lLpRIPa-EhuLKSl..........Pshss.h+p.p.t...............................................................................................p................tlpllaP....shlss..........pplhphL.+plspcppthH++hhhhsllshPlThPhsLlPl.......lPNlPhFYlsYRuaSHa+.....AltGuc+LphLl.................	0	43	82	117
+10006	PF10174	Cast		RIM-binding protein of the cytomatrix active zone	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4809)	Family	This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion [1]. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains [2].	35.00	35.00	35.30	35.40	33.50	34.90	hmmbuild  -o /dev/null HMM SEED	775	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.79	0.70	-13.90	0.70	-6.49	7	395	2009-01-15 18:05:59	2007-08-03 11:45:35	4	15	88	0	216	377	0	443.00	33	71.08	CHANGED	LpupLcps.pEpE.L+pEhEhppocLspohsplcp..........................................................hhSsELc+-+.hRccEuuclshh+pphchsptpst..+hQ.phptLQpcL.+.Qt-lp+Lhpp..pusschtp..................h-hs.tt.pRlptE+-ttth-L.hlR.....c..ohEchpLphEp.pppLssts-plcKLhEhL.....................................................Kupppsppth+RhtEt-sphpcLEslL-p+EKpp.hh..........................plHp+hphp.DsAtTc.............A.QplI-.KDop.tphE+hLcc...hpsEl.hLpSpsshupt-Rpc...plEs.+SthtthKs+................hDpst.pLuRpc........cLEshspptsDh.+p+l-hLppsLpttppctshLQsEl-tLphcL-cpcshhsKpotplpshpEEtuphusEIcch+-hh-hpptclphLQcp.....-.phpccp+phpp.p-Rl+p............ppl-cslhEhE+hht+lcp.Rpptpp.ctEph-paKcchcplcpclpshptcLpEpphpL..h+tcsspLhSst.KpcochcphcIthEpt+-cppKL.pplc+........p.psphspphstlctsssthps-sttspsElDRLh-hLccs.pp+ssp-hchucLtp....sph+hscQpcssts.....hhhp.......c+hsAphhc.hcR......cc-slppuspp..........................................pplpcL.ushcplttEh-phhhpLppoQp.LhphppcLsshcsEhp+phEEshchK...QpAhlAAluppsuphAhhEhpu.pKchsp-chtthcpE+-..........................+lVcQ.K...p.......phQpRMpL	............................................................................................................................................................p..ts..t.hptpht....p.t..................p.t.....ht.tLppcL..+.......ph......................-....t..th..t..-..-p...-h.hhp.......t.phcchphphpp.pp..ph.thppplcpL.-..................................................................................................................................................................................................................................................................................................................................................................................t.ph............p.....p...t..ptchth.p.p.tt.ptp.t.h.sp.............h-tht.chcptpt..tphtt...th.t-ht.h.t.clpc...hhp.hc.tp.ch..h..tp......p.h..t.........p..ctp.h.....th...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	59	80	165
+10007	PF10175	MPP6		M-phase phosphoprotein 6	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4531)	Family	This is a family of M-phase phosphoprotein 6s which is necessary for generation of the 3' end of the 5.8S rRNA precursor. It preferentially binds to poly(C) and poly(U).	25.00	25.00	25.20	25.00	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.49	0.72	-3.65	6	144	2009-09-11 06:05:00	2007-08-03 13:18:23	4	1	114	0	97	135	0	102.40	40	63.94	CHANGED	LSKulLcMKFMpRs+-pl-Kcts-Ecp+t...LhSsE...lstchLppoppall.EsSal.C......EsLl.GRlSFtGhNPElE+LM...........E....p.pAt+....puctt-cpscth.....DVsDpEMA	....LScsLLcMKFMQRsh...-pppKcp..h..-.E-c+c........l...huc..E.............l..shstl...p....ppps...a..ll...Ep.Sah.C........-sL.l.h.......GRMSFpGFNP-l.EKLM.....................php..sc.p........p.s..ct...p.cp.p..hth......DVoDpEMA....................................................	0	29	40	69
+10008	PF10176	DUF2370		Protein of unknown function (DUF2370)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4812)	Family	This family is conserved from fungi to humans. The human member is annotated as a Golgi-associated protein-Nedd4 WW domain-binding protein but this could not be confirmed.	22.60	22.60	22.90	23.30	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.72	0.70	-5.02	26	493	2009-01-15 18:05:59	2007-08-03 13:29:02	4	7	220	0	283	488	0	134.60	24	66.36	CHANGED	phstlssh.......p..sst.ut...thGtusDGVFsNLsAK...P-p.................tttppphPPoY-pAAADssPsYa-sshhssu.................hhtDElhl-GLPVGshhsFlWNhhlohsFQalGFLLoYlLHToHAA+pGSRuGLGLTLlpaGahM+sus.....................t.tts.thh...s...................Pssap...........p.....t....suaps.........................htsp.WluahlhhlGhhIhl+ulhsYh+l++hEchlLpsssppt	..........................................................................................thh...................................................................................................................P.P.....sYp.st.t................P.Y.t.ph.ts..............................................................................s...hp..th.....l....Gs.h.Fhhshh.huh.Fp.hlGFhh.hhhppohAu+.Guh.GhGlohhtahh.hh.t................................................................................................................................................................................t..hh.hhhhhhGhhh.hpuh.ta..hhp.............t..................	0	66	110	190
+10009	PF10177	DUF2371		Uncharacterised conserved protein (DUF2371)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4823)	Family	This is a family of proteins conserved from nematodes to humans. The function is not known.	22.90	22.90	23.10	24.20	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.88	0.71	-4.30	10	150	2009-01-15 18:05:59	2007-08-03 13:41:28	4	3	78	0	102	135	0	130.10	39	32.60	CHANGED	RQDSLRSp.p...........tstc++......+s+++p+u..-VVVVRGKl.....+LhSsSGhhllLGlllllVGlAMAlLGYWP+................................................ttt.tsttss.opspssshpspst.Gshs+hhppaLHS-+hKhLGPllMGIGIFIFICANAlLHENRD+cTKlIshR	.........................................................tph+.......h+h+.+s...cVlVV+GKl.....+LhS.SGhhhllGlLlhllGh.....uMAVlGY.WPp......................................................tth...s..ts..t.spt..hpsps...uhhh+.hhptahHs-+h+hlGPllMGIGlFlFICANslLaENRDccTKll.hR........................................	0	19	28	60
+10010	PF10178	DUF2372		Uncharacterised conserved protein (DUF2372)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4828)	Family	This family consists of proteins found from plants to humans. The function is not known.	21.20	21.20	21.20	21.20	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.79	0.72	-3.85	8	121	2009-01-15 18:05:59	2007-08-03 13:49:53	4	3	100	2	79	102	0	89.10	34	62.90	CHANGED	lVlTQhGKhGTllslp........s.spu-.........lspPsaoscV......LLGp.D-Plh+lhA+pLlstlutEsus+sllLuluLKD+Ss-sLKsltcslcpspl	..............................VllTQhGKhGTl.lslp...............s...tts-....................hscPshsspV......LLGp...D.EPLlcl....hA+....pLlpal..ot......p......uu..s...+sllLuluLK.D+Sh-sl+slhpslpps.........................	0	21	34	53
+10011	PF10179	DUF2369		Uncharacterised conserved protein (DUF2369)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4806)	Family	This is a proline-rich region of a group of proteins found from plants to fungi. The function is not known.	20.00	20.00	20.00	20.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	300	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.28	0.70	-5.31	5	148	2009-01-15 18:05:59	2007-08-03 14:07:11	4	5	72	0	105	142	0	226.20	31	59.39	CHANGED	sRhplsTIV......................ClGp+NpplVpG.L+sDoTYalDVFulcppRsoSSAYluootpT....................+cpsRouPltLp-GpLtQVcLcs++G....hKFFsFslPp..tssusQospLlVHsCsGs.VRlpLFRsGKLLt+o.tuFpGhRpFsVsul+PGc+YLlRap.sNDDEuh+TlRVh.AsSTcuspuPaPsLP-DToVKhls.hRoCSSATIAWhuopDc+.lKYClYp++psoNahE+pVsctsNhCpGslS+clh.....p.VsChYsHSPsps-.pscSlhppTIuNLtPuSTY...LLsVssstssG+uLPYRolhV+TssYC	..............................................shh...............................Chstpp..hl.t.h..pppY.hslashp..pt..shhh.st...p......................tp.......h.Lpptth..h.ltttts.....t.hpht.........p..hhhhl.sC...s...lp..lpl...ptp.lhpt...h.t.t.h.......................ps..stthYhlcl..............s.spc.t..sot.........hKlh...sTTt.scpsaPpLPpDsR.................lcshshhRpCoolTlAWh....so.-.....+....p....pYClhhpc.cs.p...........s.C.......pp.............h.C....p...................pth...hl.tL.sut.Y...hh.lhh.h......u.sl.Y..hhl+ht..C....................	0	15	27	66
+10012	PF10180	DUF2373		Uncharacterised conserved protein (DUF2373)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4829)	Family	This is the C-terminal conserved region of a family of proteins found from fungi to humans. The function is not known.	25.00	25.00	28.30	27.50	19.30	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.23	0.72	-4.43	26	219	2009-01-15 18:05:59	2007-08-03 14:32:39	4	6	203	0	158	217	0	68.90	35	21.80	CHANGED	LpYLppatps+ps....................................WKFsKp+QsallKahhs.-clPpcatshLlpYLpsLpG.suRp+Lhcpucpll	..................................................LpYLppatps+ps.........................................WKFpKs+QsaLl+phas..-.clPsp.ahshLltYlpuLpG.suRpclhppApph........	0	48	84	128
+10013	PF10181	PIG-H		GPI-GlcNAc transferase complex, PIG-H component	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4551)	Family	PIG-H is a family of conserved proteins that complexes with three other proteins to form the GPI-GnT (glycosylphosphatidylinositol anchor biosynthesis transferase) complex. It appears to be a peripheral membrane protein facing the cytoplasm involved in the first step in GPI anchor formation.	20.50	20.50	21.10	20.60	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.98	0.72	-4.34	33	259	2009-01-15 18:05:59	2007-08-03 15:55:35	4	8	226	0	173	243	1	69.60	33	28.05	CHANGED	Sllll+slGlQlsop......hh.spt..............pcFIPhscIhDlVIsEuF.psa.pVhaYLslll.........+spsp...............lhllF.p	.............................ollllculGlQhoop.......ahsupp..................................pspFIshscIpDlVINE..uh..phh.pVhaYLslll.........cspsc...............llllF.............................	1	47	89	139
+10014	PF10182	Flo11		Flo11 domain	Linder T, Bateman A	anon	Pfam-B_18862 (Release 22.0)	Domain	This presumed domain is found at the N-terminus of the S. cerevisiae Flo11 protein. Flo11 is required for diploid pseudohyphal formation and haploid invasive growth. It belongs to a family of proteins involved in invasive growth, cell-cell adhesion, and mating, many of which can substitute for each other under abnormal conditions [4].	25.00	25.00	27.50	27.50	21.70	24.60	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.81	0.71	-4.65	14	112	2009-01-15 18:05:59	2007-08-03 16:57:57	4	12	42	0	73	110	0	141.30	29	19.18	CHANGED	stssphshs.phtstshPthslsVpsVpaVtsNhYpVTlpapsspshsLppL......ppLpIlGlsssp.....sshhLautsps.s.lIs...NsscaouThhVtup....sssshhChP.sFpIpa-aspssssph..sssWp..hhspsashhhuCss.ssptp.uppshssa	............................tppsh.ph.s.h.slpsVpalp-ssYplTlphpupps.l.sL.c..L......tuLKIhGlsuPp.....tsh.Lautspp.shhI.s...sPscaosoap.....Vhup.....spsspshhP..sFpIpa-ahpusu.sph..hpsWp...hGsssas..h.sGCpt.sp....uphsh...h.........................................	0	7	32	66
+10015	PF10183	ESSS		ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4808)	Family	This subunit is part of the mitochondrial NADH:ubiquinone oxidoreductase (complex I). It carries mitochondrial import sequences [1].	22.70	22.70	22.90	23.00	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.45	0.72	-3.63	45	270	2009-01-15 18:05:59	2007-08-03 17:16:03	4	9	222	0	169	257	0	102.20	25	65.39	CHANGED	htpspt.........st..ssssupts..u+tp...............Ps................Gh......LascpP...G.....pphchEsWEhsaahuhhhslVlhulshsaK.P..Dhol.poWApcEAt+R....LEscG	..........................................................hht....................pss.s.ps.....sctt....p.........................sp......................uh.........Laspp..P...G.....pphchcsWEhsaahuhshsllhhushhsap.P..Dh...........s...........h..psWApcEAhcc....hEttt......................	0	53	87	131
+10016	PF10184	DUF2358		Uncharacterized conserved protein (DUF2358)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4457)	Family	DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.71	0.71	-4.15	29	393	2012-10-03 02:27:24	2007-08-06 10:34:44	4	5	158	0	238	556	155	112.80	25	44.24	CHANGED	tcllchL+pDhspha..scshsYuIYscDlhFpDPlspFcs..lppYphh...l+Fhsp.aFtslpl-lpclppssp....pIpsRWsl.pshshlP.....W+...scls............hsGhSphplspsG.hIhpH	.........................t..hhchL+p-h..s..p..ha...hps...hs..h..s.lYspDlhFt.....DPl........t..sacG.............hppYpt.........l...chlsp.ha...........t....p..hpl-.lhpl.....p.......p......ts......cs.......slp..sRWpl..ps.h..s.t.hs........Wc......scht.........................hsGhSpahlsp.pu.hIhpH................................	0	84	158	207
+10017	PF10185	Mesd		Chaperone for wingless signalling and trafficking of LDL receptor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4357)	Family	Mesd is a family of highly conserved proteins found from nematodes to humans. The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs) [1]. The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation) [2].	19.20	19.20	19.20	19.90	18.50	18.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.92	0.71	-4.53	7	123	2009-01-15 18:05:59	2007-08-06 10:54:47	4	4	99	12	84	133	0	158.90	44	78.42	CHANGED	tKKDIRDYsDADhtRLLEQW..E--DslE.s-LPEHhRPssslDhSplDs..ssPEslLKhSKKG+TLMhFVoV..oGsPTccE....TE-ITpLWQsSLaNsphphpRallssNRAIFMh+DGu.AWEsKDFLVpQ-RCtcVTlEsp.YsGKs..............................tp.tpsK-EL	......................................................tKKDlRDas-ADhtRLL-QW...EcD-.slE-s.-LPEH..hRPs....s....lD.h.Spl..Ds.........spPE.slLKh..oKK...G+T..LMhF.VoV.....sGs.P....Tc.....cE....oE-ITpLW.QsSLaNs..p.hplpRahVsssRAIFMh+DGu.AWEhKDFLlpQ-RCt-VTlEspsY.sGhs..............................t...................................................................	3	26	36	62
+10018	PF10186	Atg14	DUF2355;	UV radiation resistance protein and autophagy-related subunit 14	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4398), Wood V	Family	The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway [1]. There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localisation of this complex at the PAS is controlled by Atg14 [2]. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex [3].	27.10	27.10	27.10	27.20	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.95	0.70	-5.47	39	520	2012-10-03 11:38:54	2007-08-06 10:55:36	4	16	250	0	371	532	2	295.80	16	56.42	CHANGED	pCslCp....sspp.hhCssCsps...........p...Lhch+hchtplttcp-slpp+lpphlp...............................sththpth+schtpppc+hpplppplppl+pclcpp+pclpph+pslpp++sslp...tp.thtpccsp.lpphpsshc+tcpphpt.lpshhtppRshlhcplsplaslpph....................cpss........ptsas.Iu...s...........hslhsh+shpp................................................................hssppIssSLsahspllsLluchLulcLPtplshs..ppsh......................................................................shsths.cp.......stshppFhculshLshNlsaLsp........op...ulsls...hssa-shsplhp.lhphhhsp	.....................................................................................................................................................................t.....h.php.thtphh.pp...pp...lt...pplpphlp.....................................................tp.thpphptphtp.t...p.+ht........l.ppplpp.ppplppt.ppplp.chptplpp+pptht.......tt....th........p.pttp..thp..p..h.pp.p...h..p..pp......cph.h.......p.........p..hppp......htt...pppp.lhp.p.lst...laslp..............................................p.ts.............................ptsas..Is..............s............................htl..s.s...s...p....sh.ps......................................................................................hst.t...plu..s...u...LuasspLlpllu.hhL..slsL.a.lt...h....t.pup..........................................................................................................................................................................................................................................................................t..h......t................s.s.p.....pFphulhhLspslt.Lph...............pp...slph.......p..hpsh..hh..........h....................................................................................................................................	0	111	180	293
+10019	PF10187	Nefa_Nip30_N		N-terminal domain of NEFA-interacting nuclear protein NIP30	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4036)	Domain	This is a the N-terminal 100 amino acids of a family of proteins conserved from plants to humans. The full-length protein has putatively been called NEFA-interacting nuclear protein NIP30, however no reference could be found to confirm this.	21.60	21.60	21.60	22.50	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.59	0.72	-3.84	17	264	2009-01-15 18:05:59	2007-08-06 10:57:05	4	4	215	0	181	250	1	97.20	39	42.18	CHANGED	FVSpupl-E.+c.ttp.ht.......tcpscspsppp.cu+oLYEhLQppK.ctKptEa-Ep...hKlKN.h+uLD-DEsEFLDplpppc+ttEtphccEEscpLctF+	......................................FVSpuplpEt+cpc.pEthcthpp..........scsspt.ps.pcthD...sRSLYEpLQcp..K..spKQpEaEEp...hKhKN...h.............RuLD-DEspFLDplpcppcthEcphccE-tcpLcpa+..........	0	62	95	145
+10020	PF10188	Oscp1		Organic solute transport protein 1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4033)	Family	Oscp1 is a family of proteins conserved from plants to humans. It is called organic solute transport protein or oxido-red- nitro domain-containing protein 1, however no reference could be find to confirm the function of the protein.	25.00	25.00	52.20	52.00	23.50	20.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.98	0.71	-4.44	10	139	2009-01-15 18:05:59	2007-08-06 11:10:40	4	3	104	0	83	133	3	170.40	48	48.65	CHANGED	MlYlL-QRL+AQs...lsp-KuspVLcDIspslasscFlsELFpspt.....lhShstl+plhcslupCSIMRLspsSMsKLaDLMhMshKaQlhssp+PtEllp.lThsHL-ulpcllsp...sctpshlctshpplh-hassLsss-hhtlRpcLLsFLpshps+VSlhlcsshQs.psGsFhl	.....MLYlLDQRL+AQs...IssDKu..........c+...........VlsDIlssMFscKFh-ELFKPQc.....LYScculRola-+LAHuSIMRLNpuSMDKLYDLMTMuFKYQlhlss+P+-lLh.lTaNHLDuI+s.hlpD......ssslhppVDp......shppL...h.........-hYu.sLosG-athIRpTLLhFFQDh+lRVSlFL+cplQs.ssGpFl......................	0	29	41	63
+10021	PF10189	DUF2356		Conserved protein (DUF2356)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4262)	Family	This is a 200 amino acid region of a family of proteins conserved from plants to humans. Some members have been putatively annotated as being integrator complex subunit 3 but this could not be confirmed. The function is unknown.	25.00	25.00	30.10	36.70	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.48	0.70	-5.30	8	130	2009-01-15 18:05:59	2007-08-06 11:12:43	4	3	105	0	95	130	0	216.70	53	24.43	CHANGED	pLWRDllh...............pPpshsPta.GlhQLhch+TS++FLt.sRLoPEMEpKlhFlhusVKFGsQK..RYQsWFpcKYLsoPEScSLhsDlIRFIssVlHPoN-lLsSDIlPRWAIIGWLLooC.........................psssspuNuKLuLFYDWLFFDPcKD.NIMNIEPAILlMhaSl...............+paPtlTsoLL-FLC.+lhcsassptc-pIRpGVpNuh+hIh-KtVl.sLs.lh-ssKL-R-Lp.hlRcpFs-FLS	............................h.LW+Dllh....................NPpsL.s.P.pFsGlhQLLptRTSR+FLt.sRLTP-MEpKLhFh.sSpV+FGpQK...RYQDWFQ+pYLuTP-SpSLRsDLIRaICuVlHPoNElLsSDIlPRWAlIGWLLToC.........................Tosl.A.suNAKLALFYDWLFF...sPcKD.s.IMN.IEPAILVMtHSh...............+sHPs.lTsTLLDFhC.RllssFaPs..hcsplRpGVhsSLphIl-Kp.Vl........spLsPLF-s.P....KL...D...+-LRshlRcpF.EFh.....................	0	35	48	71
+10022	PF10190	Tmemb_170	Tmem170; 	Putative transmembrane protein 170	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4349)	Family	Tmem170 is a family of putative transmembrane proteins conserved from nematodes to humans. The protein is only of approximately 130 amino acids in length. The function is unknown.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.48	0.72	-3.97	8	145	2009-09-11 14:34:23	2007-08-06 11:13:35	4	3	91	0	98	132	0	98.90	53	67.44	CHANGED	LssFsEMWYaVFLWALFSSlFlHssAullAFsTLR+HKhGRF.hSIhIllMGlLuPloGGllTSAsIAsVYRAuGhsMuPlcAllaGVGQTllohllSFoRILATL	..................psasEMWYt.lFLWALhSSlFhHss.AGlLAhhTL....R+H.KhG....Ra..hSlhl....llhGhlu...slTuGhlTSAAlAGVYRuAGKpMhPhcALshGlGQThhslllSFh.RILATL.................	0	22	33	63
+10023	PF10191	COG7	DUF2354; 	Golgi complex component 7 (COG7)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4182)	Family	COG7 is a component of the conserved oligomeric Golgi complex which is required for normal Golgi morphology and localisation. Mutation in COG7 causes a congenital disorder of glycosylation [1].	29.30	29.30	31.10	30.90	29.20	29.20	hmmbuild  -o /dev/null HMM SEED	766	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.31	0.70	-13.21	0.70	-6.63	8	242	2012-10-02 15:56:29	2007-08-06 11:14:02	4	7	143	0	166	238	2	481.30	21	88.41	CHANGED	DhSpFuuDcFDVKcWlNAua+uspcssuss+sct..aluoLVhKLQLalQ-lNsulEEoStQALpsMP+VlRDlptL+pEAuhL+-pMttVpp-Ip+hEp-TupsMpsLsRlDsVKpRMQhAtcoLQEADGWupLSA-lEDsFcosDlsssupKLsuMQpSLuAls-lP-aoE+psQLEsLKNRLEALsSPplVsAhsspsl.......DQupcaVpIFpcIsRhPQLptYYpKlHKs.LhphWpchspppts.........................hshsphLopFYDpLLphhcsQh+WssQlFpc.hc.llsllll-TLusLsPShsuplspAlc+Ass-.c........................LpsLl-lassousFu+slEphlttt.tp....ssLh+lh-LlcAVauPacsFptpYGsLEcopLptpluulslctu..........ElsDsVpcL-cSlsKlhsLhpuAV-RClshTsGhulspLlpALculhtpYlopaspsL+SLRhspsl-shssss......................E-WSlhQsolplLsssG-LhppsusFEppLtsplhshuuph..p.assp..ts..p....tppuss+sshptaphlspschs-hsshhcsLhslpEcu..........................................ssshslLutsppsls+hsppsH-LsaDslF.pI+QpLtpl.s+hcsaootultE.hs.DLPsFShsPQEYITsIGQYLLTLPQHLEPLlpu.sssLchsLcssch.assppttt..-hpshADhWLuplAEuopthYp-pIhpIptLos+uAKQLATDIEYLuNVL-ALGLslstsLQpIlTLL+As.-pY+sluK.....uLsh+LuusIsphRs	...............................................................................................................................................................................................................................................h..th..h........................................t.........h.t.......l.p...lp.hptchp.s.ts.Lp.cuttht....t....h.tpl......pt..hh.........t.......t.......t.......ph................................hsttl.thppsh.h..........t.hs.th.tt.h...ht..hppp...lct.hp......l....ht.ht....t.t...................................t.st.hh...tlh......th.tp..th...a.t..............h....W...t.....................................................................h....hht.hh..http..........hh........................h....h.......h....h......h....................................................................................................................................................h...............................................t.h..............t.s..tph..ho...t....h.h...ht..h..............................................................................................................................................ht.h.t...............................................................................................................................................................................................h.........th.......h.t....hh.p.h....h..h...h..h.....................................................................h..st..hs...............P.t.hpphuphlhsls..h-sh..........................................................................................................................................................................................................................................................................................................................................	0	85	110	141
+10024	PF10192	GpcrRhopsn4		Rhodopsin-like GPCR transmembrane domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4290)	Family	This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers [1].	23.70	23.70	23.70	23.70	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.29	0.70	-5.19	23	259	2012-10-03 04:04:29	2007-08-06 11:14:50	4	6	114	0	206	328	2	222.60	26	48.39	CHANGED	shplcaclplhNss.........t..spcFSh-ppsl.phhhlhhllallhlhhshhhh.pthpppp.hchshphhshslhlphlShhlhhhahhhYu.hsGhGh.hhplhupllphhuphlhhhLLlhLuhGWTIop.hphs........shhhhhslhsllshhpsllhlh.sphhh-stppha.Y-uhsGahllhl+lshhlaFhhultp.sh..p+ps..t+psFhhhFshhshlaFluhPllshluhh.lssahRtKllphsshhhphluhlhh	............................................s..plpachhlhNsp..........s..hpcFSh-c........slhph..hhhh..l.lahlhhhh...h..h...hlptpt.hHssh.+.h..hh.s.u.l.hlp...hhShhh.hla.hhp.Yu.tsG.lG..................hthhucl...hphhSphh.hhhhLl....hL.u.hG.aols+..hph.s.......................st...h.hhshh.shh..sh.h..p..hhLhla..........t...p.....-s..t.p..sh........atac...o.sGhh.ll..h......lpl.shh......l.h.F...hhslh........h.....c+.s..........KptF.....ah.F.h.h........sh.hlW..FhshPl.h.shl.u.h..hst..ahRt.+llp.hh.hhhph.huhhlh....................................................................................................................	0	93	119	170
+10025	PF10193	Telomere_reg-2		Telomere length regulation protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4346)	Family	This family is the central conserved 110 amino acid region of a group of proteins called telomere-length regulation or clock abnormal protein-2 which are conserved from plants to humans. The full-length protein regulates telomere length and contributes to silencing of sub-telomeric regions. In vitro the protein binds to telomeric DNA repeats.	20.90	20.90	20.90	21.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.36	0.71	-3.82	31	272	2009-01-15 18:05:59	2007-08-06 11:15:43	4	8	242	4	200	275	5	111.50	31	12.69	CHANGED	sPlYl+DLlphLp.-s.ps...h-+hchALpsussLIRpKss...assElpphup-LsphLlsLps.pachppFp-hRhpuhlAllVsp...............................P.phupahsphaas..u-aSlpQRhslLssLuhuA	............................PsYl+DllphLptsp...s........h-+hchALpss.s.LlRppss......-lpchut-LsphLlpLp.....s.....chshssFpphRhpuhlAllVsp....................................Ph.psupals.pthas..sshSlpQRhslLssLuhuA...............................	0	65	108	163
+10027	PF10195	Phospho_p8		DNA-binding nuclear phosphoprotein p8	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4319)	Family	P8 is a short 80-82 amino acid protein that is conserved from nematodes to humans. It carries at least one protein kinase C domain suggesting a possible role in signal transduction and it is thought to be a phosphoprotein, but the sites of phosphorylation and the kinases involved remain to be determined [1].	21.20	21.20	21.60	21.30	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-8.92	0.72	-4.09	13	132	2009-01-15 18:05:59	2007-08-06 11:19:25	4	2	94	0	67	134	0	57.90	46	70.61	CHANGED	MSEsaaD-aEaYNacpDKtlhoG.tSGKtRTK+EushHTN+hsPuGHsRKllTKLpNoEpK+	............p-thhDpa-hYshst.ph.hhu.G..uuKtRTK.+EAut+TN+.sP..uGHpRKlloKL.N.oEp++....................	0	18	22	40
+10029	PF10197	Cir_N		N-terminal domain of CBF1 interacting co-repressor CIR	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3869)	Domain	This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex [1].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.62	0.72	-3.93	39	495	2009-01-15 18:05:59	2007-08-06 11:23:05	4	9	268	0	353	481	1	37.10	38	10.07	CHANGED	SWHPshh+Npc+VWcsEQcthpEp++lc-hpc.EhccE	.uWHPtshcNhc+VWtAEQct....ptEcKKh--htp.chpcE................	0	116	185	289
+10030	PF10198	Ada3		Histone acetyltransferases subunit 3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4191)	Family	Ada3 is a family of proteins conserved from yeasts to humans [1]. It is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. Ada3 plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage [2].	24.50	24.50	24.70	25.00	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.71	0.71	-4.40	23	232	2009-01-15 18:05:59	2007-08-06 11:23:59	4	2	212	0	178	230	0	133.70	32	22.73	CHANGED	phDasolEERLK+EL+alGlh...................................................Dss-h...ss+pDDElsAELRpLQscL+plophNptcKp+LlslscEchAaQEYpsIL--LDpQlppAYhKRl+shtK+K+...pc+pst.................ptpAssu..................sL+sLL-+	.........................................chtslEpRlKpELhthGlL................................................................................-...s.Dh....sscpDDElhucL.RphQsEL+p.sthNps+KpcLlc..ls+EchuhQEhpph.l-slDspV.pAYhKhhpshtK++p.....p+ccts.....................tt.tshpt.................tc.hhpLh-......................................................	0	58	94	145
+10031	PF10199	Adaptin_binding	KYY; 	Alpha and gamma adaptin binding protein p34	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4273)	Family	p34 is a protein involved in membrane trafficking.  It is known to interact with both alpha and gamma adaptin [1].  It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the adaptors from the coated vesicle. Another possible function is in aiding the recruitment of soluble adaptors onto the membrane [1].	32.00	32.00	32.00	32.00	31.90	31.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.85	0.71	-3.89	38	207	2009-01-15 18:05:59	2007-08-06 11:24:57	4	5	184	0	156	211	0	139.40	22	39.17	CHANGED	EppGhc..RlhEsL-sp.Wss.hc.tp.t...............................................................................................................hppcthshcps.pphp...................................................................tt.p.-...............shEplhp+lpth+cpspp..lsc......pcRccaAtchspc	.............................................................................EppGlpRlhpALpup.Wss..hthcstpp.........p...t.........................................................................................................................................................................................................................hptphtshpts.pptt.....tt............t.......t..........................................................................................t.t.tp..s....psphcl-...........................shEpLhp+lpth+-puss..LPc.ppR+phAtKsstt..............	0	52	82	125
+10032	PF10200	Ndufs5		NADH:ubiquinone oxidoreductase, NDUFS5-15kDa	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4110)	Family	This is a family of short, approximately 105 amino acid residue, proteins which form part of NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The protein carries four highly conserved cysteine residues but these do not appear to be in a configuration which would favour metal binding so the exact function of the protein is uncertain [1].	21.20	21.20	21.30	21.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.22	0.72	-4.00	6	171	2012-10-02 15:44:21	2007-08-06 11:25:25	4	4	139	0	105	165	0	82.40	31	76.86	CHANGED	MPFlDlQK+LGlNlD+WlhhQSuEQPaKhAuRCHAFEKEWIECuHGIGpTRAcKECKIEaEDFhECLhRpKTM+RLpsI+cQR-KLlKEGpYTPPP	....................................................sRCasFEpcal-C...s..c...uh...G...t..s.Ru...c....KcCphth-DahEClp+pKphpRhpslp....p....p+c+...t........................	0	29	51	81
+10035	PF10203	Pet191_N		Cytochrome c oxidase assembly protein PET191	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4114)	Family	Pet191_N is the conserved N-terminal of a family of conserved proteins found from nematodes to humans. It carries six highly conserved cysteine residues. Pet191 is required for the assembly of active cytochrome c oxidase but does not form part of the final assembled complex [1].	22.90	22.90	23.10	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-9.76	0.72	-3.93	33	259	2009-01-15 18:05:59	2007-08-06 11:26:49	4	5	238	0	182	235	2	64.60	39	59.86	CHANGED	hssSCpcl+psLttCL.cScClhhccposc-CLpss...tplPpcChtl+cuah-CKRuhlDh.RpRFRGN	.....ssuCpsl+psLstCL.pS-Clhhp.c..+..oPp-CLcps....plP.cCptL+puah-CKRuhl....Dh.RpRFRGp...............	0	50	89	144
+10036	PF10204	DuoxA		Dual oxidase maturation factor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3921)	Family	DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases.  DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites [1]. It is conserved from nematodes to humans.	21.20	21.20	21.30	26.90	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.83	0.70	-5.34	7	173	2009-09-11 16:49:30	2007-08-06 11:27:08	4	3	80	0	103	157	0	229.80	42	73.87	CHANGED	Pa..ssRsshshsspllslhllFlshhluFLlILPGlRt+............................RhhhhhpllLSLFlGAVIlssphsssWtsup.hhhssYKuFSpphl.AclGhalGLhtlNlTLt.........uhPstphsE.sIsYNEtFsWctspshscpYccALE+GLP.PlLhVAEhFohs.sshuhhpQYRhAGaYASthLWsuFssWlLhNlLL..hsVshYGuhhhhh..TGhhhLhuhhsat.h...hpsssl+lu......suVlph+.aGhsaWLsLssGlLCl...lsGlslslhchshP+slpshlphu.cps	.....................ah.ts+.shshssshhhllhlFlshhssFllILPGIRG+.............................Rhhhhl+VhhSLFlG.......AhIl...ss.phuspWtsu.p.hp.h.ssY+uFStthl..AclGhplGL.tlNlTLp.................................uhP.h...tp.........h.s....-....sIsYNEpFsW............p..........h...........s....p..........s..........hsppYtpALp+GLP.PlLhlAEhFo.p...pshshhtpYRhAG..aYsuhhLW................sAFhh.WlltNlhL..hss.hYGuhh.hhh..TGhh.lhuhhhas.h.s.h.....h..slpls................suhLphp..aG..sFW.ls.LssGlLCh...lhGhhhshhchh.Ppthpshhp...t..s..........................	1	29	35	67
+10037	PF10205	KLRAQ		Predicted coiled-coil domain-containing protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4421)	Domain	This is the N-terminal 100 amino acid domain of a family of proteins conserved from nematodes to humans. It carries a characteristic KLRAQ sequence-motif. The function is not known.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.24	0.72	-3.98	7	131	2009-12-22 15:39:10	2007-08-06 11:27:39	4	5	89	0	81	123	0	96.40	53	16.16	CHANGED	QKLApEYSKLRAQspVLK+AVl-EQupssuL+EpLKpK-poLR+hpQEhDSLuFRNpQLt+RVp.LQpELt.....lscstspKs+..ssscpsu.huppspsVhcE-L	.....QKLApEYSKLRAQspVLKKuVl...-EQApss........uL+EQLK.KDQSLRKhpQEhDSLoFRNpQLsKRVElLQ-ELs..........ls.Es+..uKKsK....csucs.suphstpptsVhtE-...............................	0	29	36	62
+10038	PF10206	WRW		Mitochondrial F1F0-ATP synthase, subunit f	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4092)	Family	This is a family of small proteins of approximately 110 amino acids, which are highly conserved from nematodes to humans. Some members of the family have been annotated in Swiss-Prot as being the f subunit of mitochondrial F1F0-ATP synthase but this could not be confirmed. The sequence has a well-conserved WRW motif. The exact function of the protein is not known.	26.50	26.50	26.50	27.40	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.38	0.72	-3.98	17	197	2009-01-15 18:05:59	2007-08-06 11:28:26	4	8	102	0	96	213	0	84.90	43	59.95	CHANGED	MuhGthPucaNsKlpGsY...paYGp.DpPhhpVKLGELsuWhuRR-KoPpuhsuuhSRuaWRappKYhp..sK+sGIushhpllsuhhshhYhhsYs+lKHaRph	..............................h..............................tDpp.Lh-VKLGELsuWlhh...RD.hoPsulhuAhpRuaa.Ra.pKYlp..sK+uulushh...llsuhhhh.YhhsY.p+..lKHcR..h....................	0	17	23	68
+10040	PF10208	Armet		Degradation arginine-rich protein for mis-folding	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4154)	Family	This is a family of small proteins of approximately 170 residues which contain four di-sulfide bridges that are highly conserved from nematodes to humans. Armet is a soluble protein resident in the endoplasmic reticulum and induced by ER stress. It appears to be involved with dealing with mis-folded proteins in the ER, thus in quality control of ER stress [1].	20.60	20.60	20.70	20.60	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.17	0.71	-4.56	8	204	2009-01-15 18:05:59	2007-08-06 11:29:04	4	12	129	6	120	194	4	131.40	47	65.87	CHANGED	-CEVClcFlsRhhpSL.scsVchcsDsIEctlhctCcss+GKENRFCYYlGAsp-SATpIhsEVo+PLSa+MPs-KIC.EKLKKKDuQICEL+Y-Kp.lDlsoVDLKKhKVK-LKKILs-WGEsC+GCsEKoDFIp+IpELtPKYs..tt...ps+TEL	..........................-CEVClphls+F...hpsL.sc..s.sp.h.s.ttI.Ep.thhchC.pps..+...s.........K..ENRhCYYlGuhp-uATtIls.Elo+PhoaphPspKIC.EKLKK+DuQIC-L+Y..-....Kp.l.DLs....o......VDL+KL+V+-LK+ILs-.WGEpCcGChEKoDal++IpE.LhPKYs................................................................	0	46	59	86
+10041	PF10209	DUF2340		Uncharacterized conserved protein (DUF2340)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4147)	Family	This is a family of small proteins of approximately 150 amino acids of unknown function.	25.00	25.00	46.60	31.10	19.80	17.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.67	0.71	-3.95	18	127	2009-01-15 18:05:59	2007-08-06 11:29:24	4	5	113	0	92	121	0	111.60	43	71.62	CHANGED	lTVRlIKSF.YRNlKNhlh+slDLpspTsc-Llc.l+pcIpTsuuh.RPFRsl..cYDoLKIYT+AHGSKTsNLVINh-cD-pWlL...............phpsts+oLh-hGVcNETElShFNhcDYhpaKtNPcpKW	.....lTVRlI+SF.aRNhKslVh+slsL..spTsc-hhphlppcltpp.....suh..PaRNh.......pYDTlKIhppAHuuKTssLVlsh-cD...-.phlL...................p..pspoLtph.GltsETEluhFshcDYhpaKtNP..p.pW.....................	0	38	53	72
+10042	PF10210	MRP-S32		Mitochondrial 28S ribosomal protein S32	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4106)	Family	This entry is of a family of short, approximately 100 amino acid residues, proteins which are mitochondrial 28S ribosomal proteins named as MRP-S32.\	  Their exact function could not be confirmed.	25.00	25.00	32.60	32.00	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.25	0.72	-3.67	8	112	2009-01-15 18:05:59	2007-08-06 11:29:54	4	4	76	0	66	106	0	88.40	44	60.99	CHANGED	NCsV-lAlTpDGRTIVCaHPuV-lPYEHTKPlPcsD.lpssspoHEplLKo+Lp..phKptc.tPspEELSKlFaTTKHRWYP+Gp..cR+tKpsPsccc	.............hpsclAlTSDG+TIVCYHPss-lPYEHTKPlPcss.....hpsst....ps+-phL+splp...phpphcptshh-pLuKhFaTTKHRWYPpup..pc+tp.sP.cc...................	0	17	21	43
+10043	PF10211	Ax_dynein_light		Axonemal dynein light chain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4001)	Family	Axonemal dynein light chain proteins play a dynamic role in flagellar and cilia motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra-structural arrangement seems to be one of the most stable micro-tubular assemblies known and is responsible for the flagellar and ciliary movement of a large number of organisms ranging from protozoan to mammals. This light chain interacts directly with the N-terminal half of the heavy chains [2].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.11	0.71	-4.46	30	362	2009-01-15 18:05:59	2007-08-06 11:30:38	4	5	126	0	212	328	14	174.70	30	36.75	CHANGED	sc-lLsoIlPPRcap.cc.uphalQhVSssPuoRpDVlpLp-pLDppLppRpAR-oGI.CPIRcELYuQCFDElIRQVTIsCsERGLLLlRVRDEl+hTlsAYpsLYESulsFGhRKslpsEps+s-hcpclppLEc-ppcLcpplpcLct+h-shc+ptpEcpptcEKp+p-ElsaLK+s.sppL+spLcpl	......................................................................h....h...pt.t.hhhp.sS.pP...s...oR.DVlpLp-.....LD....phLp......p......p...p...........A.....+....p............o....G............I....Cs.l...R...........c......c...l..YspsF........cELIR......QVTlsCsERGlLLh+lR--........h.ph....sls....s........a....p..pL.hcu....ul....s....a...uh+c.slps...c...p.t.c...t.......chpp.c....l.tp.......L.cp.chpcLpppltchpt+.h-th.p..c..pttct...pt...........tp..cth.tpclt...h...hct.t..tphp......h..................................................................................................	0	108	131	176
+10044	PF10212	TTKRSYEDQ		Predicted coiled-coil domain-containing protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4421)	Family	This is the C-terminal 500 amino acids of a family of proteins with a predicted coiled-coil domain conserved from nematodes to humans. It carries a characteristic TTKRSYEDQ sequence-motif. The function is not known.	19.90	19.90	20.10	20.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	518	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.79	0.70	-5.58	5	140	2009-01-15 18:05:59	2007-08-06 11:33:46	4	6	86	0	85	141	0	322.70	36	59.42	CHANGED	LAGQALSFVQDLVoALLNFHTYTEQRlQIFPlDSAIDsISPLNQKFSQYLHENAuYVRPLEEGMLQLFESITEDTVTVLETsVKLKtFSDHFoSYVsFL+KILPYQLKSLEEECESSLCTuAL+ARNpELapDMK+lTAVFEKLcTYVoLLALPSTcP-GLLRTNYSoVFTQluuuLHuLHDllKElSKHYsQKAoLEQELPTATQKLlTTNDCILSSlloLTNuTGKIAoFFuNNLDaFTSSLSYGPKGuTsFlSP..LSAEsMLsYKKKAuAYM+oLKKPCP-SVPYuEALuNRRVLLSSTESREGLAQQVQQSLEKIuKLEQEKEHWMLEAQLuKIKLEKENQRIAsLlKso...puGpLsssspEsusLspuuEQsEusSscup+EPTpoTSLlGMLTlTs-sp.sPDcESRE-LIKoHYMARIAELTSQLQLADSKAVHFaAECRALAKRLuLAEKSKESLTEElKLAsQsISRLQDELhTTKRSYEDQLSMMSDHLCSMNETLTKQREEIDTLK.MASK	................................................................................................................................................................................................................................................................................................................................................................................................................................................hp...tp..p.....tt...............t.t.....t......tt...h.......s...t....p....t...s.t..t......ts.h...ssph.......t....h....h........t...s.-..ps+.E.pL...Ipsaa.t+l.-Lhpphphu-SKshpaht.EscsLtp+.Lthu.-c...p+cs....hp-c......hp.ssp...........slppLp-ELpTT+psYEcQLShhS-HLsohN-pLsppp-pIpth+......................................................................	1	28	37	65
+10045	PF10213	MRP-S28		Mitochondrial ribosomal subunit protein 	Wood V, Coggill P	anon	Wood V	Family	This is a conserved region of approx. 125 residues of one of the proteins that makes up the small subunit of the mitochondrial ribosome. In Saccharomyces cerevisiae the protein is MRP-S24 whereas in humans it is MRP-S28. The human mitochondrial ribosome has 29 distinct proteins in the small subunit and these have homologues in, for example, Drosophila melanogaster, Caenorhabditis elegans, and in the genomes of several fungi [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.57	0.71	-4.05	21	297	2012-10-03 10:08:23	2007-08-06 14:08:43	4	2	268	0	222	400	31	121.40	28	36.00	CHANGED	pa..p.ss..ppPlpacaooYhu-t....cPt.sRKVVlplpsssL...sL..sc+pp+KhhhLAGsRYssc........TD........ll+hSo-+aspttQNt+YLsslLptLlcEupc..s-sapDlPlDsRHpph+................pFPccWt	.........................................p.slphphssYhupt...........cPt.sR+Vslp.lplpcL........sL..scctpcK.hh.c.L..s........G........sRYs.p.......................................oD............................llphss-+asp........ppQNtcYhhpllssLhpEutc....s....-sa..pc..h-.hchp...h................................................................................	0	80	122	182
+10046	PF10214	Rrn6		RNA polymerase I-specific transcription-initiation factor	Wood V, Coggill P	anon	Wood V	Family	RNA polymerase I-specific transcription-initiation factor Rrn6 and Rrn7 represent components of a multisubunit transcription factor essential for the initiation of rDNA transcription by Pol I [1]. These proteins are found in fungi.	27.70	27.70	28.30	27.70	22.60	27.60	hmmbuild  -o /dev/null HMM SEED	765	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.17	0.70	-13.15	0.70	-6.44	19	144	2009-01-15 18:05:59	2007-08-06 14:14:48	4	7	116	0	108	148	0	591.40	16	77.63	CHANGED	hDPphusLhsluphhshps.css.scshslhshsSGEsussLslphlpccthphpp.......hthshhhpppsstas.s......husPI+QIpau...cshcppsshlulpp.sphhlhps.htt.............h...ppppuplsss.Lhplptsph.ushsauDVsFNPWspp...QhAllDp+GNWolWcl........tpp+pppsshpsspshs.GSl........tDsp-l......ssWtpIpW.............................sschspllVhsRpshh.hchpss.p..h.....Lhpu+shspIhDl++ssp...ppsFlLTopcllWhclss..............shp.hLSW+HahDscDsoL+l..sshts....ppphhhhlaSphs.llhsathuhpsst.hshts..ssallclsspsstpt..........phpsh.hp.t.sc.spssspph...t.phhtlatlsspLslppphhsssspss..spst....ppsshcthtspp.p...t.pp..hp.........................h+hhtc..h.slp..upspps.t-hs....Yuhtlupths..................th.E.hp...t...sphspspshhphLsp.sslssh.pshp-hsshlppl.phhpspphthsshhphhhthhh..............tstspl.slashLhpsW.ss.sp.h........+-plh+p...lstplsLohlts.................................................................................pcpt.t.......splpphhphstpp.....hscsspslLspWc....ttssss.ph........pphhpsshpps....tpsphPsh+.pppssps................pt......................sspsts.ts.p.h......spo.shsp.....s...P..oQhpsst.tsRpttptt......t+KKKRtuGF	..........................................................................................................................................................................hhshh.h.........p......p.h.hhshssGpssp.lpl..ht..pt........................t....ps....h..t...............tsPlpplphs....pt.tt.........p....h...hhlph.tphhlhp......................t...spl.ss.lh.tl..pph.ss..hsDhsF..sPh..p...phAllD.t.G..Wslacl.............h.p...t.t.h......h....t..spl..................c.t.h..........................sth.tl.a...................................sp.pthllhsppph..h.hp..ht..st............................l...tp.t.ph...lhDhtt..t.......p.hh.lL.To.pplhhhth...........................t...hlSh.H...hss.pD.olch..p...h.............tt.hhhhl.S....p...h.h.hh.h..........t...............t.hhlt.s.......................h....h.....................................hthh......th...hh.........t..................................................................................................................................................................................................................................................th.thh...................h.....................................t...hhp.h.p.a....................tt..htt....hh..hhhs.hhh..................................................................................................................................t....................ht.h..t........t......hst.ht.phl.spW........t.pst..t..................................p........tp..h.th+.pttt..t...................................................................................................s......................................s....t.................s..........p......t..t.p...................p+t++h.GF.........................................................................................	0	21	53	90
+10047	PF10215	Ost4		Oligosaccaryltransferase  	Wood V, Coggill P	anon	Wood V	Family	Ost4 is a very short, approximately 30 residues, enzyme found from fungi to vertebrates. It is a member of the ER oligosaccaryltansferase complex, EC 2.4.1.119, that catalyses the asparagine-linked glycosylation of proteins. It appears to be an integral membrane protein that mediates the en bloc transfer of a preassembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum (RER).	21.00	21.00	21.20	21.00	19.80	20.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.34	0.72	-4.46	12	156	2009-01-15 18:05:59	2007-08-06 14:22:28	4	2	139	2	105	156	1	34.50	44	50.21	CHANGED	MIoDspLshlA.sLGhshhlLIVlYHalsssspct	...MIoDspLshhAshLGsshhlLlVlYHalpsNspp.....	0	28	56	83
+10048	PF10216	ChpXY		CO2 hydration protein (ChpXY)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	This small family of proteins includes paralogues ChpX and ChpY in Synechococcus sp. PCC7942 and other cyanobacteria, associated with distinct NAD(P)H dehydrogenase complexes. These proteins collectively enable light-dependent CO2 hydration and CO2 uptake; loss of both blocks growth at low CO2 concentrations.	25.00	25.00	125.40	125.20	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.02	0.70	-5.58	18	117	2009-01-15 18:05:59	2007-08-06 14:46:53	4	1	69	0	41	129	44	363.50	58	91.73	CHANGED	lIpRLpuGtALLsDoP-NllEVVGlLKSYGlVLDAYS+NLlYIAEcQFLshFPFFKYF.....................................NGc..hohsKLl+HahHDRINaEYAEYCMKAMhWH....GsGGLDsYLDSsEFpppAc+AIpA+h+pNPlhhsLppLFP-FL.EhlRphuYYouLGQFWRVMSDlFlsLSDRYDpGEIpSIsDVVsHItsGLVAsAucPITYpVpIcG-sY-llPtpAGLTFLhDsAVPYVEAVFFRGoPFhGTVSYNAQApQIPs-QucFpYGALYADPLPlGGAGIPPTLLMQDMhHaLPcYLp-aYcppsRGEcDl+VpIChSFQKSMFCVToAAIpGLtP...aPLDossPpcQtANRAYh-uWhsRlhs	..hIcRLEuGsuLLsDoP-NLhpllGILKuYuVllDtY.+NLlYIAEppFLs.FPFFKYF.....................................pGc..hphsKLh+HLhHDRINaEaAEYCM+AMhWH.....GsGthDsYLDosEFptsuc+sIpA+a+tNPl...hhsLp+LFP-ah.EQlRphuYYSsLG.FWcVMuslFh-LSDhYDpGclpslP-shpalhsGLhAsAu+PIhapVpItGEsY-IlPKStGhTaLh-sAlPYVEAVFaRusPFhGThSYNAQApQlPsDQp-FpYGsLYADPhPlGuAGIPPTLLMQDMhHaLP-YLp-aYpppsRGE-DlhVQIshoFQKSMFCVToAsI.puLtP...YPLDsssPcctpANRsahEuWhsRFh.p.	0	8	30	39
+10049	PF10217	DUF2039		Uncharacterized conserved protein (DUF2039)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3241)	Family	This entry is a region of approximately 100 residues containing three pairs of cysteine residues. The region is conserved from plants to humans but its function is unknown.	22.80	22.80	22.90	37.10	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-10.69	0.72	-3.97	16	147	2009-01-15 18:05:59	2007-08-06 15:03:23	4	4	120	0	92	144	3	91.10	46	43.81	CHANGED	sQKHQN+ssFcsshapp.s.....ppc+lps...hthssl.CpRCp-hIcWKl+YsKYKsls..psp+CsKCpp+oV+cAYHplCcsCupchclCAKCt+ssp	...s.QKHQNp.huFKsshac+.s......pp.c+lss...hhhsGV.Cp.RCK-l...........lEW+lKYsKYKPLo..pP+KCs+Ctp+oV+cAYHhlCcsCApch.clCAKCsKp..s.........................	0	36	49	71
+10050	PF10218	DUF2054		Uncharacterized conserved protein (DUF2054)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3136)	Family	This entry contains 14 conserved cysteines, three of which are CC-dimers. The region is of approximately 200 residues in length but its function is unknown.	20.80	20.80	21.40	21.40	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.39	0.71	-4.31	9	153	2009-01-15 18:05:59	2007-08-06 15:05:51	4	5	112	0	107	132	3	121.10	44	50.44	CHANGED	psps.s.sspCRsSlQG+pLlsD-cGaVCpphsl.LhsGCCs.......h...ssphasCcsC.hsspCCssYEYCVSCCLpPsppsLLEcVL.pusssp.tlhuss.pDtFEhCls+CRTsSpSV.HENcYRs.ctKHCa	.....................ss....t.ttpCRNolQG+.tLlsD-h...GaVCpRpsl..hssGCCs........................hphssscpa..sC.cuC................hs.stCCssYEaCVSCC.LpPs+...ph...lLE..c.hL...........csss.uhp..slhh.ss..pDpFELClu+CRTSS.....pSVpHENsY+ss.tKaCY.............................................................................	0	38	57	82
+10052	PF10220	DUF2146		Uncharacterized conserved protein (DUF2146)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3692)	Family	This is a family of proteins conserved from plants to humans. In Dictyostelium it is annotated as Mss11p but this could not be confirmed. Mss11p is required for the activation of pseudo-hyphal and invasive growth by Ste12p in yeast.	17.70	17.70	17.90	17.70	17.60	17.60	hmmbuild  -o /dev/null HMM SEED	895	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.71	0.70	-6.56	7	293	2009-09-11 14:24:08	2007-08-06 15:07:12	4	6	126	0	207	273	0	348.80	18	75.81	CHANGED	pp.hhphDsplhVVGllGKos........ssphNphlchslhsstspts-....csplpsaapp-splLaLhhsus.Dstslh..hscslpss....s..phh-ahpt.cspasRhLLahhpVCHhlVlVEsopsFDhoahplF+tlchlR...cKhlhph.....L.phl+ssslup.hppcsRhCsPRlLFhFptsss..............sKPcp+-.hcpLEpslE-pIhclLRpppllTNsSusuLhslPpsptFVah.ssc.hcpDslhc.l-hLhtthcps......p..-p-p...lttstshpths.s.t.hpF...ptphpstppch-polhphlhpHVp.sL.ctGh--uss..+pttpopF.l.s.pcWh-hhppLaplhl....pNspcP..s.chus..hK..s.hcsh-t.lch-pKF.tphCpcuL.huh.tYpp.hP.pYssshHcpphspAhpha.cpuRGsp.pthh.pLpp.CpphWpSutptCE..ShhupsCshthH.s.t..p............HsuushhlSoCsCGRpQshRp-Pasl+pANa-FYph.s.pC..CttL.+hpFPlapPso...sDhtsAch.......spshpsh.p.tptpcp.s-ttsp.ch.pshp..hpsspp.......S.s.ssslshph.......pssctstppsps.tpssspp...............t..tpppt+-......tt.tthth.spos-aL.GhspssSshGLLPhFPSWtLssLGsSSlYsHssGLpp..QsuFlsGusaLhPWDV.lR..............hchpsWsAshpplpsc+tu..ppu+pcc+sDhhplKlFVGhEYECuRGHRFhhs.uPDpll+s.Gsslh+-Sus+.....VlpsDMPlYhPCsC..Rs..sphAQLhRlHVVTPKAPVplhl-PKVpl..pph....saspG.......pP..............lcLspSuYWILRLPaVYpG-pGshhsPpEhss..shslhtGhLhsshh	..............................................................................t...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	2	74	98	149
+10053	PF10221	DUF2151		Cell cycle and development regulator	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3711)	Family	This is a set of proteins conserved from worms to humans. The proteins are a PAN GU kinase substrate, Mat89Bb, essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.	17.50	17.50	22.80	24.40	17.10	17.40	hmmbuild  -o /dev/null HMM SEED	695	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.20	0.70	-13.23	0.70	-6.35	6	167	2009-01-15 18:05:59	2007-08-06 15:07:27	4	5	88	0	104	154	0	447.20	40	95.15	CHANGED	M.pcspKTVFVLDHssYFuEuscphl-hDhlcus+sp......hs.luKSLWTCAVEuShEYCRIlaDlaPttKL.lRFlVSDotu+hLNo.WssssQshp-LhsAlshVGsP.sRtsPpssDhSllHGLptAIEALAc.T-.Q+E................Scsstlhc-hp......tltNcGRlIClTsA+oDscMcpLEDplspllhppNtlAAu.Sc+hh.sIspC+LVIlNhYPsG--ohVosRsLpElS..PlLpsEVHSsKAuc.lusKLspLllsHFDLASTTVTsIPMK........EEQ+AsoSANYDVELhHu+cAHs..lhpGsshhsssShK....cGusYETVTLKWCTPRtssSs-hpYCsuAhhlTPVDVsSRPSSCLTNFLLsGRSVLLEpP+KS......GuKllSHhLSA+GGEIFIHsLshsRSp.......L--PPSIu-GsGGRVsD.YRls-hGchM+ppRLhPlscp...sDslsEt.h-........ch+ppLpRhoRYaPhhhupTsIF.N.ch..tl.PLlsLIsKppLoEpDlhpCppsIasLhpMcp+p-sLshsss...GsRlKs.Kc.-EQYRlhasELEpllppasusS.+HKplhcslhssRutssptE.....-+ccuGcKh.sKtshhtK.......sstuuco-chpss.DpEc--..cs....................shsDSPsSPch.p......Kpspssl--.....................................................pththtscGshSLLslhsshlEpupSpKRpEFsGRl.sshGNhAcLYscLuEKpts	..................................................................................................h.hslho..h-s.hEhpRlh.Dlas.t...p..lphhhsD...hhlss.W.....sh........t..p..lht.h..........hu.P..........t.t.....s.h.tGL..Alp.......sLs..o..Q.t................................................................................................NpGpllhh..........T...........php....p..ptph..l.t.h.p.l.p.N...................t.h..lp.hphhhl.hhs......t.........p.t.........t.s....h...lhp.................h..tl..Lh..papLuSTolosIPMK........E-pp..ss.t.SsNYDVplhH.ttsH.......h......t................p............................................s.....pshtlpWsTs......t.....................h.....s..u.h.hoss.stSRPS.CLhpFlhs...G+.sVhLp...p................stchhoHhL.sps......ucIFlHsLs.spsh.......h--sP..sI...p-...ssus+V....sD..YRhsph.t.hhp....hh........................................................................p.sp.hP.h.t.shhh.............l..h.pllhKpphspp-..pCpphlhpLhthttct-.Lshsph...stt...h.c..........pp.c-QYRhhatELpthlph..s.o.tHpplhpsh.thpsh..............................................................................................................................................................................................................................plht.h........t..t..............................h.........................................................................................................................................	0	38	45	79
+10054	PF10222	DUF2152		Uncharacterized conserved protein (DUF2152)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3778)	Family	This is a family of proteins conserved from worms to humans. Its function is unknown.	21.30	21.30	21.40	22.00	20.60	21.20	hmmbuild  -o /dev/null HMM SEED	604	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-13.19	0.70	-6.30	6	150	2009-01-15 18:05:59	2007-08-06 15:07:47	4	4	108	0	86	149	0	440.40	38	91.23	CHANGED	RLKsh....sGhLSSpasRRLLslLhllVlhlaYlhus.hRhs.......Fsuus.s+s.sutChcsclp.Wpt.t-ch-sslps......PtE.p.h..Pal.GNGaluLDlsus.pLaVp.puR...shhh.ssFpPhlslc.tGstsEpcuosl.a+pGll+plRCh........................s.sp-ChhVpppaaAHRoRPsVaVQcIQIoNPpcpllsl-Lss.ph.sh.cthooolchhps...t.....ph.lhoGhl.sVs....sthlhlVslsspchss+LpVs.+sshc.phhhslasScPls.....spht..hph.pppApctMhclhp............hshtshcp-HhclWusLahoGhphusuKst+T.sGssINsThYhhlSpsRAPhl-...sshoppc+-slEpsLsYu-tCasuHuThp.AENLW.pchSslppLhpLhshWhLTLQKRGC+sLlpAGApGllQAMVLSFGGhpFo-sHLphphDP+sLHpsYshRGlp.YsN....spINlulllDpDsKPaLaVulcpp-p..plYAC-AGCLDEPVpLTss.+sH.FPVhVTpPlTsLLYIooDhpHLpDLRHsLHlKEll...AHEEHhhpha+......GLPhLFWhSVsulIslFHLFLhKLIasEY.......CsPusKshaRs+	...................................................................................................................................................................................................................................h.uNGhhh...........h.....................l...h.......t..............h...s.h...h......t.............t.h...h.hh..pG..hhhhpCh.............................t.shhlp.phhAHRshsplhlQplplsNs.h.p.....thph......t............p.h..t.ps..h.h.t..............ph.l.sth.......................t..h..h...hslst.phstplplt.+sphp..h..sl.h.St.sht.........p........p.hp.p.....shpthhchhp.............s.tphhp-H..thWtp.La.sGhphp......p..ps.p.s...su.plNhT.hYhhLSps..u.h.hp.........thstp.c.+p.....phcpsLsYt-tCasGHsThc.A-NLW.tchoohtplhpLsshWhLTLpKpGC+sLlt.....sGA.GhhQuMVLSFGuLpFoppHLpaphDPc.sLHpsath+sIp.Ypp....shlNluVlhct-..s.KshLpVulc..ptp...plYAC-AGCLs-PVpLTpt.psp.FPVhlTpPlTslLYI.osDhpHLp-LRHslHlKtll...AH-cHhht.........GLPhLFWhSlsuLIslFHLFLhKLIhpE.Y.......ht..............................................	0	33	40	64
+10055	PF10223	DUF2181		Uncharacterized conserved protein (DUF2181)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3748)	Family	This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.	25.00	25.00	30.20	28.50	18.80	20.60	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.62	0.70	-5.02	10	192	2009-01-15 18:05:59	2007-08-06 15:07:58	4	2	94	0	120	194	0	225.50	35	76.71	CHANGED	DuhplTWhHAsNS+ptLs-sL..s..SslphIEADVslpthpp..usEpplPIMAHPPAhsSDlTLcEWLcpVl.........sppKGIKLDFKSlpAVcsSlDlLc.sltct....lphPVWINADILsGPsss..ossVDsopFhstlpphhPpsTLSlGWTTtassshssssYTpshVcpMhcllpt.....LsQslTFPVRAulstsShspLpWL...LspopRYSLTlWouAsDsl.sV-DLlhlRcshuhcRlYYDl.EsltsQ	....................................shh.lhW.hHAsNppt.httuL.....p.........ush.h.h....lEADVhlt..tt...sscps..............hP..IMA.H.P..P....th..s.SD...TLppaLp.plh....................ss..pK..G.I..KLDFKo.lpAlpPSlslLp..phppp.....................lptPVWlNADIltGPsss....ss.VsuppFLstVpp....haP........csTlS..GWT.T..a.h.p......h................sts....Yo.phl.ccMhplspt.......LsQsVTFPVRAu.hl.t..p..S.h.s.p.l.thL.........Lpp..S.....s..R...h....oLTlW.p..u..t...s..D..h...sl..psLlhltcshshpplaYDl.cs......................................................	0	33	46	76
+10056	PF10224	DUF2205		Predicted coiled-coil protein (DUF2205)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3650)	Family	This entry represent a highly conserved 100 residue region which is likely to be a coiled-coil structure. The exact function is unknown.	26.70	26.70	26.90	27.20	26.20	26.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.62	0.72	-4.41	8	221	2009-01-15 18:05:59	2007-08-06 15:08:21	4	2	190	0	155	220	0	77.70	41	58.26	CHANGED	huschsut-lE.th-pEt+p+LIpQlLpLQsoLc-LupRV-uVKEEN.KLcSENphLupYIENL...MosSsVhpSoosp..tpK	....................phps.-hc.phphEt...+pcLl.....p.....QshpLQsoLc..s..LupRlDuVKEEs.KLcoENphLtpYIpNL....MS.s..SsVhpoos......................	0	46	76	122
+10057	PF10225	DUF2215		Uncharacterized conserved protein (DUF2215)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3817)	Family	This entry is the central 200 residues of a family of proteins conserved from worms to humans. The function is unknown.	28.70	28.70	28.70	28.70	28.40	28.60	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.55	0.70	-4.93	16	259	2009-09-10 22:40:12	2007-08-06 15:09:00	4	6	118	0	156	265	0	218.00	28	54.65	CHANGED	aslslppt.hphaRlhhhlhGllLhhhushLSpshsFYYsoGhulGllsslLlllahhh+lhP..++ohhhhhlhGua.uhuhYhlphhhpNlp.Ilhpa..........thaVlsalhhsGh......lphhlshp.ssshstpstphlpWslphluhshlhpSs..spluhuhllhshhh......thhhhslp.........hhhthtphh+...............tph...ssth+.LspcEhcpQGphcopcuLppLR...........passSPptssh.....pshu+lpsPpphuchhpuo.sHloss	.........................................pl.l.pp.hshhhhhhhhhGlhLhhh..u..phL..S.c.s...hFYYssGhslGl....h.hslllllahht+hhP....++s...h...hh.....l.lhG..uh.sh........uhYhlp.l.....hpslp.lhhpa..................................h.allsallhsGh.................lshhlshh.hss.........s..pohpl............lpWslplluhshhh.u.s...thuhshl.lh...hhh...........th..hshp.........................hh..hhhhhhp.......................................................................hh....s...+hLop-EYp..psthpTtpuLppL+...........phspp.Ppht.W......hhsplp..sP...c.hs.p.h.ut..Hh............................................................................................................................	0	42	66	108
+10058	PF10226	DUF2216		Uncharacterized conserved proteins (DUF2216)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3819)	Family	This is the conserved N-terminal half of a proteins which are found from worms to humans. some annotation suggests it might be PKR, the Hepatitis delta antigen-interacting protein A, but this could not be confirmed.	22.40	22.40	22.40	24.40	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.45	0.71	-4.80	11	174	2009-01-15 18:05:59	2007-08-06 15:09:23	4	2	80	0	104	154	0	177.10	55	45.64	CHANGED	usu--LScloDEELLpWSKEELVRRLRRsEAEKhulll-HGNLh+EVNRpLQhHLsEIRuLK-VNQKLQEDNQELRDLCCFLDDDRQKGK+lSREWQRhGRaoAulMRKEVulYLQKL+ELEt+QE-llRENLELKElC.......LhLDEE+.............sutusuGsRsSlDSQsuhs..s..u....ssRDVGDGSSTSSsGSsuSPDp	..............................s......thsD-EhhthuKE-Ll+pLR+tEu-+hshhlp+upLhpEVNRpLQhHLsEIRuLK-lNQ+LQ.......-DNQELRDLCCFLDD..DRQKG++.l.uREWQRhGRYoAuVM+cEVuhYhQKL+ELEs+Q..EEll+ENhELKELC.......lhLDEE+......................ss.usu.G.up.sShDuptsh...s.....st......hhRDlGDGSStSSsGSssSPDp..........................................................	0	20	31	63
+10060	PF10228	DUF2228		Uncharacterised conserved protein (DUF2228)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3952)	Family	This is a family of conserved proteins of approximately 700 residues found from worms to humans.	25.00	25.00	27.20	29.90	20.50	22.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.53	0.70	-4.83	9	139	2009-01-15 18:05:59	2007-08-06 15:10:22	4	6	101	0	86	138	0	213.50	42	61.87	CHANGED	GLpLVGPF-lLuGcacssphtps.sahhHWRaaYDPPEFQTllhsspsothHhGYaRDpPsshss.hluhN-sKpusphshlG-NlFsAllhFLp+ph+pps.pKtphuAhcKl.t.LpctApphshtLpppschhKpRcKclVsKshHtuGlV..VPhs.Ksc.......lGYR.LscoD..AsLK+ll+slsc...spscpccpcshs.lQtlhThlphANDECDaGhGLELGhDLFChGs+thHclht.LLshAYshLpRspFspI	....................sLpLVGPa-lLuG+a+htpt.....tps..sa..hHWRFaY..DPPEFQ..........Tlll.....s.spp.....sthHhGYa.R..DsPschPs.hluhN-.u..p..pss.h...Gs.NlFsAlhhal.cchp....t.hs.p..p.thshhppl...........tt...Lpchspp..shpLppps.hh..........h+.pRp+.+.lVs+TFHtsGlV..VPhD.+sp..........lGYRpLsto..D..spL++lhctlhc....utscpp+.psh.........s.lQ.EhhohsphAsDECDaGh..GLELGhDLFsh...Gp..c....h........hpphhtpLLshAYpLLpRs.FhpI....................	0	34	40	65
+10061	PF10229	DUF2246		Uncharacterized conserved protein (DUF2246)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3994)	Family	This is a family of proteins conserved from worms to humans of approximately 300 residues. The function is unknown.	21.80	21.80	21.80	24.40	21.40	21.60	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.85	0.70	-5.11	9	180	2009-01-15 18:05:59	2007-08-06 15:10:35	4	5	127	0	98	165	1	216.90	32	67.15	CHANGED	tLhp+sstsRuhshsssuuScpshhshhs.shhs+s.shPc-shGsFGspDpphpLsGslsassclsuhshphcs.h..ph.lP-sls.s.pscppphhhsp.lsE.......lh.pclpps..p..hssuplEsuhppCP-LL++-htplFP....shsssslTVlTlTQ+s......hupthEp-REpLhp+FlpuAKEIC.sLhotGYWADFIDPhSGtsaFushTssTLacTDsRaRpLGF+lEDLGsCpVIpHphhGTphFVGTIFTsAPscSslht+Lhu	.................................................................................s.................................................t...t.ht....p..h.sp....s....t.............................t..h........t....th......t.lt......................ht...............ht.p..splEhslpsC..P.cLL+c..chcplF..P...................ph...........ss...splhllsl..oQ+o.....p.s.hs..hspp.sEtE+EhLhc..cFlpsAp-lChsLp........spGYWADFIDPpSGhsahu.s.h.s.ss.slh.-sDp...........p.a..p.p..L.......Gapl..ps.hGsC+VIpHshWG.o........psas...........GolFTsAssp...h.pl..s................	0	36	50	75
+10062	PF10230	DUF2305		Uncharacterised conserved protein (DUF2305)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3975)	Family	This family of proteins is conserved from plants to humans. The function is unknown.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-12.07	0.70	-4.98	27	346	2012-10-03 11:45:05	2007-08-06 15:11:11	4	7	258	0	233	951	208	239.00	24	77.85	CHANGED	schlllhIPGNPGLhsFYppFlptLtpph..............sspatlhsloauGa.shpsps................pchasLpsQlcHphshlcphls............hch+lhllGHSlGuYluhcllc+hs.................phplhtshhLhPTltchucSssGphhohh....hht.hhhhhhssh.hhhhhthLPttltphLl.phhhsss.................sh.ssshh....hhs.pslppslaMAtpEMppltp.c.....-phhpt....................+lhFaaupsDpWss.phhc-lhcths..p.........ss.....hpls-.cslsHAFs	...................................................................................s...llhhIs......GNPGlht.aYt.......FhptLhp..h.........................................................t.ph.lhshuhhGa.s..spp....................................p..tcha..s..L..p...tQl..c..a...phph..lpph..l...................................tphpllllGHSlGuYlshclhcch..........................................thplh.tshhL.....a...........P.......T..l..p.......c.hs..p.S..ss.Gph....hs.h.............ht.h.h..hhh.hhshh...........hhh......th.....lPt..hh...hp....hll..phhht.................................th.hshh......lhp..ps..ltps.l.h....hu.tpE......ht.p...ltp.p........pphht.....................h.......................................plhhha..up..pDtWss.phhcclhp.ths...............p......................h.lsp..psh.HuFs.....................................................................................................................................................	0	79	124	193
+10063	PF10231	DUF2315		Uncharacterised conserved protein (DUF2315)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4094)	Family	This is a family of small conserved proteins found from worms to humans. The function is not known.	21.40	21.40	21.60	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.45	0.71	-4.26	6	120	2009-01-15 18:05:59	2007-08-06 15:11:38	4	6	88	0	72	116	0	115.80	41	54.95	CHANGED	ppDaIGPPDs.SNLRPlhh+hs-NETcLE++LRthRpEsppWNs-FWucaNhpFpcEKE-Flcpc.......L+cEuGpppclsA--MucFYKsFLDKNaptHhhYNhcWY++NhsllhLuhtVsLpRlapth	........................DhlGPPDthSNLRPlhhhh..scsE.o..L....E....p.............cLRthRpEsppWNppFWsppNhpFpcEK--Flppp..........................l+ppsG..ptpl..sA-.-MucFYKpFLs+NappHhhYNhpWYc+NhslhhhhhtVtlpphht.h................	0	29	35	54
+10064	PF10232	Med8	Arc32; 	Mediator of RNA polymerase II transcription complex subunit 8	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3583)	Family	Arc32, or Med8, is one of the subunits of the Mediator complex of RNA polymerase II. The region conserved contains two alpha helices putatively necessary for binding to other subunits within the core of the Mediator complex [1]. The N-terminus of Med8 binds to the essential core Head part of Mediator and the C-terminus hinges to Med18 on the non-essential part of the Head that also includes Med20 [3].	25.00	25.00	25.10	25.70	24.20	23.20	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.45	0.70	-4.84	7	254	2009-01-15 18:05:59	2007-08-06 15:45:29	4	6	216	8	171	240	1	224.60	26	88.67	CHANGED	Mpp............spcph..........tsL-ulhpRLspLppSLsphltpLp......pchch.sWsoh.spFsll.upLsolophLtppp.shLcspslhPh.hhPs+scp..............sllsshLRTKssPcVE-hhttsctthts.tssputpp.................lhp.s+hhpph.............hshlochR-.Eh-..upppht.ppshp.tcsphllttht.upshp...................................t.p...sh....t.t...........ssslhp........hpou....s.pR	..................................................................p.h.............tsL-slhpRlspLppSLtshhtplp...................pp.th.sW.................sol.sphsll...sspLpolschL.........p.......c.......p....p.....sh........hc.shllhPhsh.Ps+sc-................................sl.lsshLRTK.-P-....VE-h.pphpt...t.u.s.ph.ss.c...s..utp.p..................................................ltphsch..hpph...................................hphlsp..tc.....-h.....-..tp...st.t.t......t....pp.p.......p.....p..........t-..........tphls.tt.h.t.utsht..................................................................................................................................................................................................	0	48	83	135
+10065	PF10233	Cg6151-P		Uncharacterized conserved protein CG6151-P	KOGs, Finn RD, Coggill PC, Bateman A	anon	KOGs (KOG4085)	Domain	This is a family of small, less than 200 residue long, proteins which are named as CG6151-P proteins that are conserved from fungi to humans. The function is unknown.  The fungal members have a characteristic ICP sequence motif. Some members are annotated as putative clathrin-coated vesicle protein but this could not be defined.	26.40	26.40	26.80	29.90	25.20	26.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.49	0.71	-4.10	25	228	2009-01-15 18:05:59	2007-08-06 15:52:44	4	5	197	0	155	227	0	109.10	35	61.65	CHANGED	hGllshlLChALGlANlFph...ssl.IlFullsllpGhlllFlElPhLL+ICPhospFssFl++hssNahRAuhYslMAllpalSlshtsTSLlusAlhLsloulhYuLAult+Q	...................................hGllshlhChhhG....lhN...lhsl.....ssl..Ishullpl..hsuhlllhlEsPhhhph...sshus.shsphlc+h.ssa.RAshYssMAll..lsls..h..s..hoSLlus....Alhhs.oulhYuLuult+p......................	0	38	68	120
+10066	PF10234	Cluap1		Clusterin-associated protein-1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3647)	Family	This protein is conserved from worms to humans. The protein of 413 amino acids contains a central coiled-coil domain, possibly the region that binds to clusterin. Cluap1 expression is highest in the nucleus and gradually increases during late S to G2/M phases of the cell cycle and returns to the basal level in the G0/G1 phases. In addition, it is upregulated in colon cancer tissues compared to corresponding non-cancerous mucosa. It thus plays a crucial role in the life of the cell [1].	24.20	24.20	24.20	34.00	23.90	24.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.61	0.70	-5.19	15	186	2009-01-15 18:05:59	2007-08-06 15:53:50	4	6	127	0	126	186	4	229.40	42	63.34	CHANGED	RhLGYPRlISM-sFRsP.....NFtLVA-lLhWLlp.........................RYEPss-Isssl-oEp-RVhFlKulspFhsTKu+IKLNs+KLYtADuaAV+ELLKlTslLhsAhpos.....stp-E-s.....ottphslusKlsDLKtsRpLuS-lTs+GuuLaDLLsKEl.pl+-sRppslu..........RshElsplE+sl+puIpsspsclpphps.LsslpuDcssLEuKIc+KKpELERspKRLpuLpsVRPAaM-EYE+lEpELpclYppYlc+aRNLsaLEpQL-shs+tEptph-	..............................................RhLGYP.RhlSh-sFRs.P.......NFtLVu-lLhWLlp.........................+a-Ppspl.s..s.l-oEpcRVhFl+shsph...hh.....sKu+IKLNsKKLYtADGaAVpELLKlsslLhpAhpsp.....................................t.t-pp..........shhph.s.lss+.ht..-lKt...sRpLuS.-lTppGAsLa-LLucEh.ph+p..Rppslu..................+shElsp.hE+sh+..slpph.tplpphpp.lsslts-EssL-sKIc+++.ELERspKRLpsLp............slR..PAaM-EYE+hEpELpp.YphYlp+aRNLsaLEppL-phpchEpth....................................	0	54	68	100
+10067	PF10235	Cript		Microtubule-associated protein CRIPT	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3476)	Family	The CRIPT protein is a cytoskeletal protein involved in microtubule production. The C-terminal domain is essential for binding to the PDZ3 domain of the SAP90 protein, one of a super-family of PDZ-containing proteins that play an important role in coupling the membrane ion channels with their signalling partners.  SAP90 is concentrated in the post synaptic density of glutamatergic neurons [1].	23.70	23.70	24.20	25.80	23.00	23.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.70	0.72	-3.63	17	204	2009-01-15 18:05:59	2007-08-06 16:22:19	4	4	187	0	153	182	0	90.10	43	72.48	CHANGED	oclsTPssh+cus............................+ssss.Gsptl.scNKLLSpttp...sPYush..ssC..chCKsplcQ.Gp+YCppCAYpKs..hCAMCGKpl..sspsh+poss	.................sclhTPDsaKcus..............................pso.spu.G.uR+l.sENKhLosppp..............hsPYu...........p............h....sp..............C..+lCKspVHQ.Gu+YCQsC.AY+KG..lCAMCGKpl.hsTKsY+pos..........	0	54	78	119
+10068	PF10236	DAP3		Mitochondrial ribosomal death-associated protein 3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3928)	Family	This is a family of conserved proteins which were originally described as death-associated-protein-3 (DAP-3). The proteins carry a P-loop DNA-binding motif, and induce apoptosis [1]. DAP3 has been shown to be a pro-apoptotic factor in the mitochondrial matrix [2] and to be crucial for mitochondrial biogenesis and so has also been designated as MRP-S29 (mitochondrial ribosomal protein subunit 29).	23.10	23.10	23.10	23.20	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.90	0.70	-5.49	29	361	2012-10-05 12:31:09	2007-08-06 16:22:52	4	8	283	0	251	385	6	276.70	23	66.47	CHANGED	slVRctol-l...hctlppt.......ptsppsh+hllsGppGoGKSlhLsQshsaAhpp...sWlVlplPpspphlpusspat.ss..p.thasQPhhstphLpchhpsNp.phLpp..lp..locca.hh............tpsstsspoLh-LlphGhpcsptuh.ss...hpAlhpELpspus.............hPllhslDshsthhps..opY+ssch.......p.Icsc-Lslsphhhshlt.....spsshssGssl..LssTusspssp..sh.hsLtttts...................-Pah.....c..h.t.h.................shpVs.shoccEscshhcYatcsshlpcp............sscphspEchhhsusGNstEL.+h	..........................................hlRp..shcl........hp.hppt......................p.tt.sh+..h.ll.....hGtpGsGKohhLs.psh.p.auhpp....sWlllalPp.u.p.th.sp...s...spp.hh.ss...........p..........th.........asQPh.stphLp.........phhpsNc...phLpp...lp......lppc.a.hs................................................................tpthtts.psLh-llp....Gh.p.....p.....sp.....h..us.....ss....hthlhpELptpsp.................h.lLlslD...shsthht....oph+p.....ph.......................p.ltsp-Lslsphhh.ch............sppsh.sGshl....lstou.t.t.p..........h....s..lhttts.......................................ssah.........................................ht.ls.shs..pEhpshhpYahppthlpp....................................pp.h.cphhh.ustss..h........................................................................................	0	96	144	210
+10069	PF10237	N6-adenineMlase	DPPF;	Probable N6-adenine methyltransferase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3350)	Family	This is a protein of approximately 200 residues which is conserved from plants to humans [1].  It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteristic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes [2].	23.20	23.20	23.50	23.20	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.21	0.71	-4.57	31	349	2012-10-10 17:06:42	2007-08-06 16:25:33	4	12	224	0	245	348	10	157.00	29	54.77	CHANGED	QLSQFWYu--TAptLu...ctllpssscs.....stIAhlSAPSlYttl+p.............phsspplhLhEaDcRFsl.hutc..Fs.......aYDYNpPhclPtpl.ct..phDhllsDPPF......LsEEC.pKsuhTl+hLh+s................ph+llhsTGctMpchs.phl....sschssFhPcHppsLuNEFRCYuNF-s	...........................................................hSQFWYu-cTsphLs....ct.lhp.....ss..p.s...................splAslSsPolattl+p............................tts.ph..pshLhEaDpRFsh..a.st-..Fs..........FYDas.p........P..h........c..l..s..pp......h....pp....ph-...hllsDPPF......Lsc-ChpK...h...up...ol.chLhp.......................................cll....h....sTuth.tth..htphh............shp.s.ta.Ppatp..Ls.pahhassat.........................................................	0	78	127	198
+10070	PF10238	Eapp_C		E2F-associated phosphoprotein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3395)	Family	This entry represents the conserved C-terminal portion of an E2F binding protein. E2F transcription factors play an essential role in cell proliferation and apoptosis and their activity is frequently deregulated in human cancers. E2F activity is regulated by a variety of mechanisms, frequently mediated by proteins binding to individual members or a subgroup of the family. EAPP interacts with a subset of E2F factors and influences E2F-dependent promoter activity. EAPP is present throughout the cell cycle but disappears during mitosis [1].	25.00	25.00	37.10	26.20	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.08	0.71	-4.27	15	144	2009-01-15 18:05:59	2007-08-06 16:52:27	4	2	111	0	99	138	2	130.80	42	54.62	CHANGED	LY.DsctD-c-ccWVccph+tt....................tsssoDAlLsCPuChTslChcCQRHEpYpsQYRAhFshNCplsc-pll...p+phsspcp+csppcscpstptstt..............................................................................ssEhY+sVpCspCuTcVAVaD.c--lYHFFNVLsS	..............................................hY.DPchDscDptWVstpR+sh....................................................................sSDAV.LsCPuChTTLClDCQRHEpYpsQYRAMFVhN...Cpls.c.-clL..h.tt...ppc.p...pp.c..t...tpp.ppt..t.t.....t....................................................................................ttptp-hY+PVhCspCuTcVAVhD.cDEVaHFFNVlsS..............	0	43	59	76
+10071	PF10239	DUF2465	FAM98AB; 	Protein of unknown function (DUF2465)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3973)	Family	FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.	25.00	25.00	25.90	25.40	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.01	0.70	-5.22	13	277	2009-01-15 18:05:59	2007-08-06 16:52:43	4	9	106	0	148	226	3	270.10	39	72.72	CHANGED	lLDsLcsLGY.cGPlh--s...sLppAspuGhuSs-apsLstWLsscL+llssl...-Eplo...ss-Dh-o.FpLElSGhL+ELuCPYssLsoG.lssRlpspccpLhLLhaLsoELQAs+llts++sppttpcp.........sosshQtlpslshsLslscs.ssslshhthFspIps+l..pchlpph.........spsplupPLL..KcsLsspQWccLEplspsLpsEY-hRR+MLl+RLDVTVQSFtWS-RAKs+tsphschapstRpsLss....psslslAcLLAARpDl..upl.+TSSushRcpTssuIN+lLh.G+VP.DRGGRssEhtsPs.EMPsWpKRp-GG	...........................................................................................................t.........h.tuhpt.Ght..ss-aptLshaLss...plp..hspl.......-Eplp.........ts.s-...h-..p..F.hElSuhLtEht.............CPatsLhsGclppclhppps..pLhLLhaLhoELpAs+hlphpp..ppt...pt........................................ssphhp.-lpthh.sLuhscs....ssshs.h..thhstlcp.Kl..p-hLs.pl....................sssplucPLL...ptsLsstpW...Ep...lEpl...............s.psLtsEYcsRRphLlKR....LDV..T....lQSFtWSDRAKs.p..s-.plsplapPhRpsLss..........coslolAcLLA.....AR.pDL..uplh+TSSushRcp.T.ssuINKVlh.GpVP.....DRGGRssEhpsP..............MPsWppRptt........................	0	39	53	95
+10072	PF10240	DUF2464	Fam125A; 	Protein of unknown function (DUF2464)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4000)	Family	This is a family of proteins conserved from worms to humans. Members have been annotated as FAM125A proteins, but their function is unknown.	20.70	20.70	21.30	22.80	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.52	0.70	-5.04	12	190	2009-01-15 18:05:59	2007-08-06 16:53:13	4	6	92	1	109	163	0	219.10	34	81.91	CHANGED	pPlTulshlushspsPpsassIspThD.ussAsLh+s...Fsp+sshYLChSps......sh.s.Vlsslplls-KsslPhGas.lscshDocppsh+KKplCl+hhP+soscsAlsDIplsu+sKpsP.sYphlG-IsuhhIahKpus.....P.slPcspsho........................................pshpshslsu.........sspPuPshPht.s.o.......psts.htts.hhpsuslYslSuh-GVPFhlpP+F....ssss.ssps.hthplcolsclcpEYsYsFssE	.................................Ploulsh.sus..tspsPpsas....s.lupTsD.Gs-AsLa.+s....FtpKs.sR.YL....Cho+shs........sh.ssVlsDhplls...K.-.slPhGF.sl..p-ThDopptsh+......K.KRlClKhhP+.suscsA.....lsDIp..lh.u..+........o........Kp..sP..t.Y..phl.G.-lsuhsIWh+hup.............lPpsps.s..........................................................ps.ps..p..ss.........ss.pPu....Psh.s.t.s.s..................................ttts...ttts...h..ptu..sl.hshouh.DGVPFhl...p.+h.......t...t.t.....h.....hplpoht..clpccapYsF.hE................................................................	0	29	39	76
+10073	PF10241	KxDL		Uncharacterized conserved protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3443)	Domain	This is a family of short proteins which are conserved over a region of 80 residues.  There is a characteristic KxDL motif towards the C-terminus.  The function is unknown.	24.00	24.00	24.20	24.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.86	0.72	-4.08	12	243	2009-01-15 18:05:59	2007-08-06 17:10:16	4	9	211	0	171	217	0	85.50	31	44.06	CHANGED	ssRhtshhsstclsshlttQpph.u+Lptppc.LLphpsLupsRLppspscFtpth+hhp-hKcDL-ahh++lculKuKhtppYPpta	.................pphtshlsstcl..sp.hlttQpph....s+hpppsc.Lhph.psluppRLpphpp....cF........tctt+slp-........hK.cDL-hlh++l.........cslKuKltppaPcta.......	0	46	78	132
+10074	PF10242	L_HGMIC_fpl		Lipoma HMGIC fusion partner-like protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4026)	Family	This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans [1] and hypospadias [3], and LHFPL1 is transcribed in six liver tumour cell lines [2].	25.20	25.20	25.40	25.30	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.63	0.71	-4.28	18	458	2012-10-03 00:20:40	2007-08-06 17:10:50	4	5	97	0	283	414	0	165.10	32	78.27	CHANGED	hulLWslholshAhlplluFlpPpWlss.......ssp............sspsuphGlaphCh.......hhp..hthpCsshshsFtslsSus....a.psushFluluhhL.LsslshhuLhshCp.....spola+lCuhhQhluulhlhlGChlYPhGWcSscV+chCG.cuspaplGtColtWAahhAIluhhsuhlLoFluhlLus+	.....................................hGslWs...lholshuhhshlsFhpPhWlhs.......s..............................................tspss.FGlaphC...............................thhs..ht.pC.ts...h..........sFss.IPSss........a.+s.us.hh...luhuhhL.....lss.l.sh....h.u...L....h.hh...Cs..................s.t.ola+..ls..uhhQh.hu..u.......hhlhlG..sh.laP.GW.s...........upcl.+.p....hCG...tpss.tap.l.G.p.C.sltWAahhAlhuhhsuhlLshhshshu.p......................................................................	0	69	96	171
+10075	PF10243	MIP-T3		Microtubule-binding protein MIP-T3	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3809)	Family	This protein, which interacts with both microtubules and TRAF3 (tumour necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3.  The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved [1].	32.30	32.30	32.80	32.40	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	539	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-12.98	0.70	-6.04	13	257	2009-09-11 16:48:08	2007-08-07 14:41:36	4	16	131	1	160	235	12	349.50	20	82.10	CHANGED	hcGLYTssEhcusslpDK-sKltFLQKhIDllphsoGcsLts+PuKIVAGpEPE+TNELLQtlu+suts.pLspcpAV++l...ttuppps.sshsp.sp-tcscssppcctcccpppcc+ccsc.c.ppppcttp.ppph...c-ppp.pE+c+p.ccKpppsstccpc.sccppp+ppsptcppctp..........................................................t.tpptpp..pppcs+ppstpp.sucsccttpstctcctpsct.s.-ps..t..tp....................................................t.p..hpt....s.p........t............t......t............................................................................................................................s......stssoAR.usPR.Kcpp.....t..sttt.uchhssVlh-shp......s-s--c-phhh.tttt.sp................st...s.....ppt-pcGtL.Vp+ILETpK-h-stsupsp....ttppt.................tsptppshssc-lppLRpplQpLs+SspPLGKlhDaIpEDIDuMppELphW+pEt+pptpthpcEpphT-sAlcPLpspLtpLEppIsDppsKIssl+usILpN-p+Ip+hltsl	.......................................................................................................................................tt.htp+p.tKhtaLpphlthh....t..h.spst+lluG.EsctTN.hLQhhu.sh.......hp.t..thhpth..................t..t.t.........t...tt......tt...t..t.......t.p....p..t.t..tt.ttp.t..p..t............................t...................t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	79	101	139
+10076	PF10244	MRP-L51		Mitochondrial ribosomal subunit	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4045)	Family	MRP-L51 is a family of small proteins from the intact 55 S mitochondrial ribosome [2]. It has otherwise been referred to as bMRP-64 [1]. The exact function of this family is not known.	25.00	25.00	35.40	35.40	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.19	0.72	-3.96	8	96	2009-01-15 18:05:59	2007-08-07 14:52:15	4	2	87	0	65	98	0	92.90	50	57.29	CHANGED	hPc.KshDRWo-KRAhFGVYDNIGILGDF+hHP+-LIhG.PsWLRGa+G....NELQR.hIRK+pMVGsRMhh-D....hHNLpKRI+aL.....Y+RFNRpGKHR	..hP.h+shDpWsEKRAhFG..D.IsI.......LG......sh.chHP.pcllhu.PsWLRGapG....NELQ+.hlRK++Mlus+hasps....h+sLpKRIpYL.....YK+hNR+sKh........	0	17	22	46
+10077	PF10245	MRP-S22		Mitochondrial 28S ribosomal protein S22	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3890)	Family	This is the conserved N-terminus and central portion of the mitochondrial small subunit 28S ribosomal protein S22.  Mammalian mitochondria carry out the synthesis of 13 polypeptides that are essential for oxidative phosphorylation and, hence, for the synthesis of the majority of the ATP used by eukaryotic organisms. The number of proteins produced by prokaryotes is smaller, reflected in the lower number of ribosomal proteins present in them [1].	25.00	25.00	25.00	25.00	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.59	0.70	-4.97	6	129	2009-01-15 18:05:59	2007-08-07 14:52:31	4	3	90	0	79	119	0	209.00	47	67.02	CHANGED	pPlFhcc-VQpLLpshTpL-LD.KVFR+Rss+s.spscaKhMT--QL-cphhpslEpAcphLQMPPVlc.+p-ssc.VlAKDhuLKuh..uTsKaVFTDITaslscpcRpIVVREPDGTLpcAshEpRcRlNQlYFPLpGRplhsPhMFc.-cpLpchL-pscaEFVLDRsCVQFEP.-s-Yp+lotpVY-+lNE.................oppF-hLRSTRHFGPhAFaLAhp+tIDc.LLhDhIp+DhLcsuspLltLhptLH..P	.............................................hFhctcVQplLhphTtlsLp.KsF+.th...t..p.....psspaKhMTptQLccthppshctA+hhLpMPP.Vlp.R...tshsc...VLucDthLcGh..-ouKaVFTDIoaulsc+-RhIVVREP.sGTLRcAoaEERDRhhQlYFP+cGRclhsPhhFp.-.Ep.....Lpphhppscat....lLshshsQFEPDs..s-Yh+lpppsY-clsc.................ptpa-lLRSTRHFGshsaahs.p+pIDs.LLh-.lpc-hlp-AspLlpLhphlH....................	0	31	36	59
+10078	PF10246	MRP-S35		Mitochondrial ribosomal protein MRP-S35	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4078)	Family	This is a family of short mitochondrial ribosomal proteins, less than 200 amino acids long. that are highly conserved from worms to humans. The structure has previously been referred to as MRP-S18 but the current numbering fits the preferred nomenclature from these authors.	24.40	24.40	24.80	29.10	23.30	24.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.12	0.72	-4.10	6	114	2009-09-11 12:55:10	2007-08-07 14:59:26	4	5	84	0	67	106	0	96.20	56	45.93	CHANGED	ppsspSFuSLLRpShhlQLGsscGKlllGKIFHlV--.DLYIDFGhKFHCVCpRPAssGEcY.RGoRVRLRLcDLELooRFLGuopDlTlLEADAsLLGLlpspsp	...............s..sscSFAShLRpSsLhQ.hGs.u.csKlVlG+IFHlVp-....DLYIDFGuKFHCVC+......RPph.sG..c..p.Y.+...Gs+VRLRlhDLELoo+FLGuspDhTlLEADshLLGl.ps..p....................	0	20	25	48
+10079	PF10247	Romo1	Mit_gmP; 	Reactive mitochondrial oxygen species modulator 1	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4096)	Family	This is a family of small, approximately 100 amino acid, proteins found from yeasts to humans. The majority of endogenous reactive oxygen species (ROS) in cells are produced by the mitochondrial respiratory chain. An increase or imbalance in ROS alters the intracellular redox homeostasis, triggers DNA damage, and may contribute to cancer development and progression [1]. Members of this family are mitochondrial reactive oxygen species modulator 1 (Romo1) proteins that are responsible for increasing the level of ROS in cells. Increased Romo1 expression can have a number of other effects including: inducing premature senescence of cultured human fibroblasts [2,3] and increased resistance to 5-fluorouracil [4].	24.10	24.10	24.90	25.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.19	0.72	-3.78	19	272	2009-09-11 01:43:06	2007-08-07 14:59:42	4	2	243	0	191	236	1	65.30	47	65.22	CHANGED	sosa-+l....KMGhhMGssVGsshGhlhGsasshptGstspthhtslGphhlsSuuoFGhFMulGollRs	............PSsa-+h....KMGhhMGs..................sVGhshGhlFGsauhh+hG.......hts.ptlhpslGphhhsSu.uTFGhFMuIGosIRs..........................	0	53	101	156
+10080	PF10248	Mlf1IP		Myelodysplasia-myeloid leukemia factor 1-interacting protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4049)	Family	This entry is the conserved central region of a group of proteins that are putative transcriptional repressors [3]. The structure contains a putative 14-3-3 binding motif involved in the subcellular localisation of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila [1]. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.10	0.71	-4.66	9	258	2009-01-15 18:05:59	2007-08-07 15:00:23	4	2	114	0	123	239	1	155.10	36	64.12	CHANGED	MRpMhtuF.u-PFu...hlSloDtph+u.sR.usstt..........ssa....hhuMsuhhhsMhshMpshhtsh-ph.ossssspoFSSSoVhoYSss.GDusPKVYQtTSpTRsAPGGI+ETR+olRDS-SGlE+MuIGHHItDRAHIlcRScN++TGDpEERQ-FINLDEu-AtuFD-EWppcs	.............................................................................................h....tsh......s..s.t.............t.....t..t.............................s........h.shst.hh......s..h.......h..s............M.ph...............tp..h..tph....ss.s..s.s..spoFs..SS.oVhoYSps....sst....PplaQ..s..o.oppR.suPG....G..l..+..ETR+sh+DScoGl.ccMuIGHHItD..RuHllp+ppNp+oGcpEppQ-al.N..lsEs-AtsFDcEWppc..................	0	32	47	83
+10081	PF10249	NDUFB10		NADH-ubiquinone oxidoreductase subunit 10	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4009)	Family	NDUFB10 is a family of conserved proteins of up to 180 residues. It is one of the 41 protein subunits within the hydrophobic fraction of the NADH:ubiquinone oxidoreductase (complex I), a multiprotein complex located in the inner mitochondrial membrane whose main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. NDUFB10 is encoded in the nucleus.	22.20	22.20	22.20	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.73	0.71	-3.99	8	155	2009-01-15 18:05:59	2007-08-07 15:00:34	4	2	122	0	94	150	0	111.50	40	70.28	CHANGED	DtPVThFR-.lVEp.ps+sKasYYHpcaRRVPslspCtssDhlChaEA-hQaRRDhtVDpEIVplLppRhcsCpQhEupsHh...QsCuK.lcQaccsscsa..+YGDLGAYusARKshMKQKHRMlhER+	.................DhPlThhR-..hl-...spp+h.aYHppaR...RVPslspChpsDhlChaEAc.Qa+RD+hVDpEIlpIlp-RlcsCtp...h...EG.....ssah.......QpCt+.lcQapcsscsa..+Y..t-LGshh.ss+pshhKQKpRhh.ct.......................	0	32	46	70
+10082	PF10250	O-FucT		GDP-fucose protein O-fucosyltransferase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3849)	Family	This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese [1].	26.80	26.80	26.80	26.80	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.21	0.70	-5.34	62	1215	2009-01-15 18:05:59	2007-08-07 15:00:56	4	28	188	6	759	1192	4	302.80	22	67.15	CHANGED	llh..s.G.GhNppRss..hhchlshA+hLNt...........TLVl...............P.hpp..hhWpcss.p.....Fsc...hF-l-p.........hhphl.sslclhchl.............Pphhsth....................................................phhhshphs....hsssphahpp..h..hhtch...........pVltlstssspLssphhshpl...Q+........uLpaspcIpphupphlp+hh................................psssalulHLRhp.Dh..hpsC.h.tht..ptt.htt.p............t.p..ps..hphpspsPhtspts.....shlLpslth...ps.......splYlAosp..........ht...th..psLpshhsphh...+pplsstc-ht.h.s..sphAtlDhhlsspu-hFlssp...ss.hsthlttcRchh..s.h........................ssF	...................................................................................................................................................................h.....s.G..Ghsp.+.t..........hhshlshA+hLNt.......................................................TLVl...........................................P....htt.....ha........p......c.s.....p........................Fpc........hF-h..ct................hh...p....l......t..slpl..c.l..............................P..h.t....................................................................................................................t....hph...t.....hss..ph.hhpp......hhshh.p............................tslt.l.....s.t.......h...s.spl...s....p..hs...ph..............p+h..........................................htuLpas.........p...l.pph.u...pph..lpchh.....................................................ts...s.alulHL.R..........h.c...D.h.........hptC....................t...h.tt.p...............................s..hph.psp.s.Ph.t..spts.....................shhhp..thsh...ps...................s..tl.Yl....Assp...................................hht..t.t.h....tsLp....phas.phh......p+ppl.h..s........p-...ht..h.t................sthA.t.lDhhlshpu-h.Flss....ss....hsthl.tcRphhsh.......phh.......................................................................................................................	0	207	476	627
+10083	PF10251	PEN-2		Presenilin enhancer-2 subunit of gamma secretase	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3402)	Family	This entry is a short 101 peptide protein which is the smallest subunit of the gamma-secretase aspartyl protease complex that catalyses the intramembrane cleavage of a subset of type I transmembrane proteins. The other active constituents of the complex are presenilin (PS) nicastrin and anterior pharynx defective-1 (APH-1) protein. PEN-2 adopts a hairpin orientation in the membrane with its N- and C-terminal domains facing the luminal/extracellular space, and the C-terminal domain maintains PS stability within the complex [1].	25.00	25.00	25.60	26.00	22.70	24.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.28	0.72	-3.76	11	135	2009-01-15 18:05:59	2007-08-07 15:39:15	4	2	126	0	86	119	0	92.60	43	78.83	CHANGED	lPNEcKLpLCR+YahsGFAhLPFLWhVNssWF...F+EAFtKPuasEQppI+pYVltSAlGhhlWsllLoTWlshFQh..pRspWGshuDhlSFhIP..LG	...................ssEcKLsLCR+Yah......u.......GFAh....LPFLWhVNshWF...F+-AFhtP...sas..EQppI+pYVht....SAlGhllWsllLsoWlhlFQh...RstWGshuDhlSFsIPhG.............................	0	31	45	66
+10084	PF10252	PP28		Casein kinase substrate phosphoprotein PP28	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3375)	Domain	This domain is a region of 70 residues conserved in proteins from plants to humans and contains a serine/arginine rich motif. In rats the full protein is a casein kinase substrate, and this region contains phosphorylation sites for both cAMP-dependent protein kinase and casein kinase II [1].	25.00	25.00	25.90	25.70	22.80	21.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.03	0.72	-3.96	22	247	2009-01-15 18:05:59	2007-08-07 15:39:49	4	6	192	0	177	239	2	84.40	51	39.93	CHANGED	sNPN+ssppp.pphpp.....h..s............s.spLSRREREtlEtQpA+cRY.KLHspGKT-pA+ADLARLAlIRcpREtsAtR+EsEKct+	..............................................................................tNPN+st.pps..p.pssp......lshs.............................ssspLSRRERE.plEKQ...cA+...ERYhKLHttGKT-pA+A.........DLARLAlIRcQRE-AAt++EtE+ct+.....................	0	53	88	134
+10085	PF10253	PRCC	PRCC_Cterm;	Mitotic checkpoint regulator, MAD2B-interacting	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3903)	Family	This family constitutes the major, conserved, portion of PRCC proteins. In humans this family interacts with MAD2B, the mitotic checkpoint protein [1,2].\	\	\	\	\	\	     In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing [3].	20.90	20.90	20.90	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.47	0.71	-3.59	43	260	2009-09-11 16:00:24	2007-08-07 15:40:11	4	6	218	0	186	243	0	214.30	19	52.85	CHANGED	lsLFuLs............sspptsssssss.............tsussYpPhhhsspttts.tsst..sts.pstpsspsssps.s.tt................................t..........slutup+Rphht+t...............pspllchss-pph.ssspchhhpt.t.ct.sspt...p.sslpsht.................t.uKHpLppLlptApsp+-tLE-paAsuRpN++pAuuKYGa	...............................................................................................................................................................................................................................................................................shFuh...................................................................................................t........t.....................t..t..........................................................................................................................................hts.............thstpth+phhs+tt.t...............phpll-lssDcph...sss..p....p.h...htpths.tct...shps...thp..s...sht...................t++KHQls.Llpp........A.pppc.cLcppaups+hs++pspuKYGa................................	1	61	98	147
+10086	PF10254	Pacs-1		PACS-1 cytosolic sorting protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3709)	Family	PACS-1 is a cytosolic sorting protein that directs the localisation of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef [1].	25.00	25.00	25.60	28.60	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.53	0.70	-5.84	8	272	2009-01-15 18:05:59	2007-08-07 15:40:32	4	4	94	0	174	211	0	351.90	47	46.84	CHANGED	VYDQLNpILlS.DutLPE...sllLVNsoDWQGpa.....lu-LLQspphPVVCTCSsAEVQAlLSulloRIQ+aCNCNSpsPpPVKVullGuQpYLuAlLRaFV-pLupKo.PDWLsHhRFLllPL.GS.HPVAKaLGulDsRYSshFhDsuWR-LFsRsEsssosppt........................sDlluRIpQYlsG.AsssHQLPIAEAMLThKp+.............DEDSsQpFlPFlGVVKVGllEsspuo........G.D.-DusslS...........................tul.So.SPP...psoshuK-u.uTPP......................sSPShsuuhsu.uSPs....s-ulGLQVDYWsus.PsE+++.........-u-+......+Dt.ouKNTLKusFRSLQVSRLPpuG....puphssoMoMTVVTKEKNKK.....................................sshFLuKKsK-KEs-.SKSQsIEGIoRLICSAKQQQsh.LR........VhIDGsEWsDVKFFQLAuQWsTHVKaFPIuLFGtoK	..............................................lhDQLspILlS..Ds..tLPE...sllLlNssDhQGQ.h......lup...lLQpp........phP.l.VsT..sSss-lQAs.hssllo+IQ+aCNsNop.PtsVKlulsGuQpYhuulLRhF.V-pLupKs.sDWLsahRFLllPL...G................S...HPlA+YLuS.....lD.+Ys..shF.........D..sW+-LFp+.Es.ss..p...........................-...lssRltpYlsG....Ass..spQLPIAEAMLsh+pc....................DE-S..t.QpFlPFlu..s.VKVGhl.E.ssuss.......sDs-Dusss.s................................................................sl...So...oPP....pss..s...h....+.......t...s.so.PP.........................s.S.Puhs..suh..s..s...u..ps.........u-hhtLQVDY.Whst..s.s-c++....................cs-K.......cD..ssKNT.LK....ssFRSlQV.....SRLPpuG..........ps..t.h.s.ss.MuM.....TVVTKE......Kp.KK...........................................................hhhL.sKK.sK-K..-h-.......u.KSQsI-G.IuR..LICoAKpQpsh.LR..................................................V.IDGV.EWsDVKFFQLuAQWsoHVKaFPlslFuhs.............................................	0	34	47	94
+10087	PF10255	Paf67		RNA polymerase I-associated factor PAF67	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3677)	Family	RNA polymerase I is a multisubunit enzyme and its transcription competence is dependent on the presence of PAF67 [1]. This family of proteins is conserved from worms to humans.	19.90	19.90	19.90	20.80	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.43	0.70	-5.59	26	467	2012-10-11 20:01:01	2007-08-07 15:40:55	4	6	266	0	232	338	15	296.80	40	76.52	CHANGED	cpRhsSacNYssLFshll.......supss......................ssLpLPs..WlWDllDEFlYQFQshspa+s+htpps..t.................-cht.l...ttp.spsWsshslLplLpuLlp+SpIpp.hph.pts...hp..s.....hsssh...sspslhthLGYFollGLLRlHsLLGDYptALKsLcsI-l.s+cu.las+VsssaloshYalGFuYhMhRRYsDAIRhFsplLlalp+pK....p.hpppsaQ.stl.Kps-pMYtLlAIshsls...Ptp...lDEoltptl+E+.Yu................-chhp.lppu...shpsFc-lFshuCPKFls..Ps.ssshcss...h.........-shppQlplFhc-VppQptlsplRSYLKLYsolslpKLAuhh-l...................-s-.......................pl+s.LhshKpcs+pl.hhstu.slhcGchhss...u-lDahID............pDhI+ls-s+.st+pas-aFl+pltKhc	...................................................................................................h...s.....h.hthhtEalaQht.h..ap..................................................at......h.thh..hh..s.h.................................t...hhh.hGaauhlslh+hpslhGDa..ulphht....lph.t....................t...h...l..s.hsh.YahGas.hMhpcY.-u.p.h.thl.hh.p.p.............t..........K..-phh..LhsIsh.sht...........Ptt.............lD-slptthpEK.as.............................DKhh+.MppG...s..s...sac-LFsaACPKFlo..Ps.ss....sh-ts..sh.....................-shchQhplFh-EV+QQhhhssIR..SYLKLYTThslsK.LutFh-h.............s.p............................................................phph.LlshKp+hpph..W..s.u......u.........h..L-Gc...u.............s-hcahl-.....................pshlhIs-sc...tptatcaFhpplt+h...................................................................	0	87	126	185
+10088	PF10256	Erf4	QRDY; 	Golgin subfamily A member 7/ERF4 family	KOGs, Finn RD, Coggill PC, Bateman A	anon	KOGs (KOG4069 & KOG4101)	Domain	This family of proteins includes Golgin subfamily A member 7 proteins as well as Ras modification protein ERF4.	26.30	26.30	26.30	26.50	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.53	0.71	-4.23	32	473	2009-01-15 18:05:59	2007-08-07 15:41:10	4	7	230	0	323	429	0	117.60	28	53.06	CHANGED	hVtI.Rca....tsshhspF........ps.taPsp..................................L.psh.lstp-FcphlsplNph.LtcAhsshshpshl-shlsslT..hhlh.hhh.....hshhc+..................pLpclppal......pphNp....phhptpGl...pllsP+cpG.Lplsh	...........................................................................h.....p.h....stGhsspFpo...cFPsp........................................L...su+..lstp-FcpolpplNsh...htcuhps......hstt..shhts.hhsChT...hhh.hhsh.........................hshhc+............................................s.h+plp+hl......ppp.Np.....cla.t..........hG..L.............phh.shcps.h....................................................................	0	90	148	238
+10089	PF10257	RAI16-like		Retinoic acid induced 16-like protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3695)	Family	This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.	20.50	20.50	20.70	21.90	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.20	0.70	-5.52	27	432	2009-01-15 18:05:59	2007-08-07 15:53:27	4	6	190	0	274	417	1	336.50	29	42.16	CHANGED	CLEahLpcpIL-sLhpLuhs...shss...Gh+ppslphaspLlup.pps...lLsatsltRPlhcL......................................lphssps....usss........................Ep-hVplLpslCsplppcPtLLshahpspppp...................................................................t.t.sh....ttpssasLFshLlsas+pp........................GRlGphARcuLLhllshu.....p.shu...................................................................................palsp.oslss.......................lhustLu.uLYspLPppl....p..........l.uhsh.......tpp..................-hsths....tL.tFhuhLpasssllpps+s....................tlsssLhcthpptFL.slltPuLLpsS-...tuhhsshshLptlLcplspssLlcphlpFLLu................................ppp.t.....tth.lhppLlppps+ho.clshssh...tlh-sllttPspthLhsLlLcsL	.....................................................hhEahlpcpl..hpplhphuht.....chss......th+tp.lthaphLlsp.cps.....LLt.at.slhcslhpL.......................................lphsuts.......sssh.......................................Epch....V.LLst..lCsplt.p..c.Pt.lLphahpsp.p..t....................................................................................................................................................................................tstspa..LFshLlsal+pc........................GplGppAR-uLLhlhulu.....ts.shu......................................................................................................................................................................palsppo.hCs.......................ll...usG.Lu.uLY..opLPpplc...........................................l.u...s..W.....h.ttc...............................................Dh.ths..............tLstFhs.L-FCs...sllph.A.+s..........................................................l.tp.pLhchlp.ptFLhslhtPuLhpso.............................tphlssouYLch..............hL+.......pl.......s.......ps.sLlpph.lpFlL...................................................................p.pp................spts.......lhcpLlp+hsp.....c.lshsoL.......thFcpLlthsscplhhpLlLp.L.........................................................................................................................................................	0	79	115	189
+10090	PF10258	RNA_GG_bind		PHAX RNA-binding domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3948)	Domain	RNA_GG_bind is the highly conserved U3 snoRNA-binding domain of PHAX (phosphorylated adaptor for RNA export) whose function is to transport U3 snoRNA from the nucleus after transcription [1]. It is characterised by having two pairs of adjacent glycines, as GGx12GG.	25.00	25.00	27.60	25.00	22.50	24.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.73	0.72	-4.29	17	161	2009-01-15 18:05:59	2007-08-07 16:04:49	4	16	122	5	121	157	4	81.30	37	19.68	CHANGED	clsscluppLpE.+s-LlhRllpslG.phshpLhpEThpIppsGGhhsssGsR+RTsGGVFhtLlKp...p.plsc-phctIatc-+cpp	.............................lss-lu..h+LpE...Kp...cLltRlVphlG.c...tsl-LhpE.....Ttc.lEpsGG.....hhl....hsG......s...R...RRTPGGVFhpLlKp...p.plspcph+pIa..-pph..................	0	41	63	97
+10091	PF10259	Rogdi_lz		Rogdi leucine zipper containing protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3992)	Family	This is a family of conserved proteins which have been suggested as containing leucine-zipper domains. A leucine zipper domain is a region of 30 amino acids with leucines repeating every seven or eight residues; these proteins do have many such leucines. The protein in Drosophila comes from the gene ROGDI.	29.40	29.40	30.00	29.90	24.50	28.20	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.75	0.70	-5.29	24	229	2009-09-11 08:31:40	2007-08-07 16:05:10	4	4	203	0	164	223	0	258.20	25	80.33	CHANGED	ElcWLlcp.lpssLsplh-sLpcCsthLh..............tt.s.phsLSos.........ps-...plKGllTRsGstIsphslpl+h.................schsp...hhhph.s.sps.hhLpQlpsspstlspulsllsshpths......................phpstsplhp.lptlhpplppu+ptLp..........hPscss....hhh.tpssssp.........................FsPsLssp..............lulclhIspscLslpl+sLctlp.......t.hst....sshshhsplh.th...pp......................................................................................tsh-.hscshsa..ssps.................................................VhhpcKhpVposDPhLhushsKLsultphlpphhssLss	..................................................................................................EhpWllpp.lpssLtpLpchLp-....Ctthhs..............................................s.tptpphsloss.....................................ps-.pl...KGhlTh.Gstlspu...clpl+h......................s+tsp.....hphs..hp.sp..htLpQlpsspsplspulp.llsshptsh.......................................................................................phpsusplhphlstlhtpL.pcu+spLp.............hPts.s.....h..htsst.sp...................................................................FsPsLPss.............................lslphhlppscLsltlhpLcshp........................ss.h.sh...........tt.........................................................................................c..sthhpa...tsp.......................................................................l.lpchhcVps...P.L.sh.shhss..t.htphhttlt............................................................	0	40	73	126
+10092	PF10260	SAYSvFN		Uncharacterized conserved domain (SAYSvFN)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3249)	Domain	This domain of approximately 75 residues contains a highly conserved SATSv/iFN motif. The function is unknown but the domain is conserved from plants to humans.	25.00	25.00	28.10	27.60	19.40	18.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.42	0.72	-4.21	9	137	2009-01-15 18:05:59	2007-08-07 16:05:22	4	5	114	0	96	133	0	70.90	41	37.18	CHANGED	lhlllWllhhsluhchs.FGslFllhShhhhIahNhtp...RppGEhSAYSlFNcsscpl.GThsAEph-R-lt	.............h.hhllWllLhslhh..c.l-..FGhlahllShFhhl..ah.shcs.......t.+cpG........E..hSAYSVFN.sCcsl.GTLsAEphER-lp..........	0	35	50	77
+10093	PF10261	Scs3p		Inositol phospholipid synthesis and fat-storage-inducing TM	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3750)	Family	This is a family of transmembrane proteins which are variously annotated as possibly being inositol phospholipid synthesis protein [1] and fat-storage-inducing. The members are conserved from yeasts to humans and are localised to the endoplasmic reticulum where they are involved in triglyceride lipid droplet formation [2].	20.50	20.50	21.30	21.70	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.97	0.70	-5.33	40	321	2009-01-15 18:05:59	2007-08-07 16:05:44	4	6	218	0	223	312	0	213.20	27	67.70	CHANGED	.tshsY...ass+cNllNhhFVKpG.WhWTolhhhhh..lhhh.............ststtps...st.phh...............................hptlhRallsTlhWhlhTp...hh.h.slhDplhshTGGpCphssst...............................................................................................................houtsC+ptGGp...........................................WpGGaDlSGHsFLLshsoLhLhpE.............................h..htphhtsh.th.t......................................hhphhhphshhlsssLlslWhahLlhTslY..FHohhEKlsGhlhGhlshhll.Y	....................................................................sYhup+pNlhNh.hFVKhu.WhWTshhhh.h..lhhh........................shhhstt.....................................hhptlh+hslsThhWhhhTp.............lhstl.hhTG.pC..s.h...................................................................................................................t...hhoptpC+tt.GG.h...........................................Wp.............GaDlSGHsFlLshsshhlhpE..................................hth..htph.tt.t.....................................................................hphhhphhhhhhshlhslWhahLlhTsl.Y..FHshhEKl...hGhlhuhhshhhhY..........................................................	3	58	101	169
+10094	PF10262	Rdx	SelT; 	Rdx family	KOGs, Finn RD, Coggill PC, 	anon	KOGs (KOG3286) & COG3526	Family	This entry is an approximately 100 residue region of selenoprotein-T, conserved from plants to humans. The protein binds to UDP-glucose:glycoprotein glucosyltransferase (UGTR), the endoplasmic reticulum (ER)-resident protein, which is known to be involved in the quality control of protein folding [1]. Selenium (Se) plays an essential role in cell survival and most of the effects of Se are probably mediated by selenoproteins, including selenoprotein T. However, despite its binding to UGTR and that its mRNA is up-regulated in extended asphyxia, the function of the protein and hence of this region of it is unknown [2]. Selenoprotein W contains selenium as selenocysteine  in the primary protein structure and levels of this  selenoprotein are affected by selenium [3].	22.10	22.10	22.10	22.20	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.81	0.72	-3.95	82	990	2009-01-15 18:05:59	2007-08-07 16:06:05	4	6	744	31	497	872	69	87.60	31	61.58	CHANGED	sclpIpY........CspCpahhR............ushhsQ-LLpoF.ss.......t..clsl.....................................................................hs....us.sGs..F-ltls.....sp.....................llas+hpsu.....................GFPsscpLhphl+st	..........................................................................................plpI.Y...........C..tp....Cp.ahh+.................ushhupcLh.psFss............tl.t..pV..sL............................................................................pP.....so..uGs.FElpls................sp.......................................hlW...s+pp.sG.....................GFP-sc.tLpphl+s.h............................................................................	0	167	270	391
+10095	PF10263	SprT-like		SprT-like family	Finn RD, Coggill PC, Bateman A	anon	KOG3931, COG3091	Domain	This family represents a domain found in eukaryotes and prokaryotes.  The domain contains a characteristic motif of the zinc metallopeptidases. This family includes the bacterial SprT protein.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.55	0.71	-4.57	148	2631	2012-10-03 04:41:15	2007-08-07 16:06:41	4	16	2330	0	664	2121	615	152.10	24	66.24	CHANGED	lpphhpphspph.aps..htt.........plpas...........chppsAGp........shhppp..................................................................................pIcls.hllpp......spp..tlhp......................slhHElsHhhhahh..........tcspsHGs.ca+thhpplss.....................................h..phhcpass.p........................pahapC............................sCst.h..tpptpl..cppp.....................................................................atCt.......................pCp.uplthhp	................................................................................h..thhtphs.phFtp...hp..................pltas..........................................pht.o.ouGp..................hh..hcst.....................................................................................cIc.lNshlhpc................spp....hltp......................llhHELsH.hhlaht..............t+st.H.sc...-...........a+thhppVhu............................................................h.sp.hhcpath.p...........................tpa..YpC.....................................pC...p.................+p....tp....l....p.hpp.........................................................................................apCs......................pCt.tpLh...h....................................................................................................................................................................................	0	194	353	536
+10096	PF10264	Stork_head		Winged helix Storkhead-box1 domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3897)	Family	This is the conserved N-terminal winged helix domain of Storkhead-box1 protein which is likely to be a DNA binding domain. In humans the full-length protein controls polyploidization of extravillus trophoblast and is implicated in pre-eclampsia.	21.20	21.20	22.50	21.40	21.00	19.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.43	0.72	-3.80	8	151	2009-01-15 18:05:59	2007-08-07 16:06:58	4	4	78	0	92	140	0	78.10	53	9.84	CHANGED	MoPIsQSQFIPLuElLCssISDhNusphsVTQEsLhp+LpppaPGhshPSp-lLYsoLusLl+ERKIYpTucGYFIVTPQ	........MoPIuQSQFlPLuElLChAISsMNuAppsVTQEuLhE+LsppaP.G..ls..sPSpElLhpTLspLl+ERKIY.Ts-GYFIVTPQ................	0	20	29	55
+10097	PF10265	DUF2217		Uncharacterized conserved protein (DUF2217)	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3831)	Family	This is a family of conserved proteins of from 500 - 600 residues found from worms to humans. Its function is not known.	25.00	25.00	36.90	36.70	24.70	24.00	hmmbuild  -o /dev/null HMM SEED	515	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.62	0.70	-5.74	11	211	2009-01-15 18:05:59	2007-08-07 16:07:11	4	6	90	0	112	184	0	382.80	38	89.17	CHANGED	hshushstl+los.utK+llhusAhGsluLhhhA+pL+RR+t++c.......t...hh..........op+s.ut+tspsoupR.p......sssscsNDshSsluSttsuKpSuSupSluShpshpSsussuss..ussW-sts..p-sh...sssssosEsLYlMGMELFEEslppWEpALsh+pctst..u.hs.................sspst-Fsc+LEsLLptAYpLQE-hphhh...cssshh...............sD....c+shthshhststshptscssSlsSsDSFhSAsElh....-ph-hp..shsh.shc.tshYEEALpLsc-GcVsCRoLRTEhLtChoDsDFLAKLHCVRQAFpsLLpDcsNphFlu-sGRQlLouLls+AcKsPKcFL-uYE-MLpalpps-sWssschELEuRGVpsMsFYDIVLDFIlMDAFEDLEsPPsSVhAVlpNRWLSsSFKETALsTusWSVLKuK+phLKsP....sGFhuHFYsloEplSPllAaGFLGP+ppLp-lCsaFKcQlltFL+DlFDh-KVRYoolEpLAEDILplh+RRs-llhsYh	.........................................................................................................h.......h..s..sh+hlhhshshush...h...hhup.h+R+t..................................s.h....h.t.hstpp...................ss.ppss.p..hsh.hs.u...u+..suss........tShh......uh............h.S.t.ss.s...s.....hpt.s...t..h.......h..hssppL..hh...GMEhhEcslppWEpALsht.pp...t.t....s............................................................................................p..ptcFhcclpsLLptAYpLQ.Epht...h...h....ss.hh.......................D....cps......hshtt...s...t....ht..t.sp..shsSt-SFh..SAh....E.h....-.hpht..t...h.....p...hshYppAhphsc-spl.sR......sl............R...o-hhtC.uDt-aLAKLHClRpAaphlhp-....tsp.ahscsG+phlssLhhhup+sPKtF..sa--Ml.ah.pspp...a..sphp.ELtsRG......VhshsFaDllLDFILhDuF-DL-sPPsSl.sVlpNRWLssuFKETAlsouhWSl....L.K..tK+p.hh.hs....sGFhuHFYslsEplSPlhs.aGFLGP..p...pL.-lCthFK................pQll.aLtDhFshppsRaooh.thucDlhph..pRsp.l...............................................	0	32	39	75
+10098	PF10266	Strumpellin		Hereditary spastic paraplegia protein strumpellin	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3666)	Family	This is a family of proteins conserved from plants to humans, in which two closely situated point mutations in the human protein lead to the condition of hereditary spastic paraplegia. Strumpellin contains one known domain called a spectrin repeat that consists of three alpha-helices of a characteristic length wrapped in a left-handed coiled coil. The spectrin proteins have multiple copies of this repeat, which can then form multimers in the cell. Spectrin associates with the cell membrane via spectrin repeats in the ankyrin protein. The spectrin repeat is a structural platform for cytoskeletal protein assemblies.	25.00	25.00	45.20	32.30	21.50	23.40	hmmbuild  -o /dev/null HMM SEED	1081	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.63	0.70	-7.15	12	186	2009-01-15 18:05:59	2007-08-07 16:07:20	4	5	115	0	130	181	15	759.30	41	92.15	CHANGED	soIIAElLRLupaIPp.F...s+t-ppcYucIl.hDFpYFptt-thEscIpps.cL.pLDE-h+poal.llpRFatlFcSlacYhhDLppal-ElppGhalppTlEolLpst-GKQLlCEulYLYGVMLLlhDhpIsGhlRERlLVoYhRY.....+usu-.sNhs-VscLhRuTGYsssss.s............................sYP.pYFsRl.lscphIshlIGRlRoDDlYp.ht.YP.P-HRSsALusQuuhLYVhLaFsPplLpspsuhMREIVDKaFsDNWlIsaYhGhTVsLhsAWcsFcAA+sAlpNTls.pslp.hhp+hppphsplhsphpplLpEGhLsEphlLDslp.plhshlR-sNVslRWlhLH.......................spppt+pspphl.h..phspcplhpLLLsouQhEhpl+phhpslLppKpp+Wpcs+cpusp+hpcLuchFSGs+sLscsppsppLppWFtplupcIppLshs-s..stuuRpI.pLlpALEpVp-FHQlssNlQVKQalt-TRphLppMh+hlNIc-csLhplthluDhSYAWclls...sasshMQppI+ppPphslplRusFlKLuShL-lPhlRIsQupS.........D......L.oVScYYSsELVsFlRcVLpIlPpohFslLtpIIpl.TNsl+EhPo+L-KcchK-aAQh-pRtpluchTtsIuhaopGILAMcoTLVGlIclDP+QLLEDGIRKELVppIscthapsLlFs..........t....ptpssphppcLspLupplcGhRpSFEYIQDYVNlpGL+IWp....EEhsRIlpapVEpECNuFl+pK.l.t..WpSpYQSp....IPIPpa.sh....stpuhsFlGRLspcllplT-P+solals.hsuWa-hcs.hpEVlus+.hauplpcslGshGLsuLD+Lhuahls+cLpphlpphpttl...-pthhsslpsltspLp....stsshscp..shchYtphhpphpthh......................splhthlhplGQhQllRppIutcLphpsKlcSspL.ssLcshNcAlLtD.lppHh...........ppspopPhPsp....llsslssaLpssGlp-PhpKlY..........................................hsscshPph.slhLhlhsLtpl..s+hpascplsshls.pctps....lDspsLhlGlhslL+QFpspppphaLsaluQal	......................................................................psllAElhRLtphlP..a.........................ttt..cat.ll.hDFpYhp..-.h-t..plptp.tL.tl-cchhps...hlpRFa.hFpulhtYh.-l...palp-lt..p...Gh...alp.oh-slh.s.cu.pQLh......sEshaLaGshLLlhD.ph.G.lRERhlluahRh...................p..pss...sphcclstL..h+sTuh........................................................................s.........pYPpt...aFtRh.hsp...hlphllupl+sDD..lYpt....a.P.Pp.HR.SsALu.QuuhLaVhLaFts.phLpsp.shMREIVD+aFsDNW..l................lshahGhslsL.........t........WtsacAApsAlttslp.t.tlp...htp...t.....tp...p......hpthlpcG.....lppphl.....lp.ph..plh.hhRpsNsslRWhhLH...........................tt.pphtp.l.t.....thp..t.lhpL.LLpsuphEh.l+phhtphLtp+ptpWtt.+pps.pph.cLuphFuG.hs.L.sp..pstpL.tWF.phupp.........l.pLphtp....ttsuRhh.plhpALcpVppacplptshplpphlt-opt.LppMh+hlslp-chhhphphlsDhSaAWtllp...tah.hhQptI+.pPt.shtl+uhFlKhu......Sh.......L-lPlhRlsQspS.........D......L.sVSpaYSs-LssalR.pVLpllPpohFt.L.plh.l.sp.hhc.hPs+lpKcc................l+cauQht.Rhpl.AphTttluhaopGlLhMcpThlGllc.lDP+pLLEDGIRKELVppls.thpt...L.Ft.....................................t.t.h..pLtthut.hpuh+pSFcYlpDYlpl.GL+la.....EEhpRIlphtlptEsp..sFhppp...h.....p..app........hshP.h..........t.u....sFhG+LhppllthTs.sp..ohahp.h.sWa.........p.ps..........p-lh.s.p.hhs.ltpslu..GlsuL-plhshhlsppLp.h.lt..htt.l......h.thhtth.ttlt..................s.....th..tt.....phY.thhtthtt.h.......................s.hhphlh..plGphQllRp.Is.pLp.ss+hcup.L..sslpshNpull.p.ltt................................................................t...shstt......hl.plpthLphsGh.pPhpplY..........................................lp.s.p....h....h..shh.hlhhlspl..s+h.astp....hs......hh..tt..ts...hD..shhhGhhslLpQFp......hlthhs.h.................................................	0	57	72	102
+10099	PF10267	Tmemb_cc2	Tmcc1; Transmemb_cc2; Tmemcc2; 	Predicted transmembrane and coiled-coil 2 protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3850)	Family	This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.	23.30	23.30	23.30	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	395	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.27	0.70	-5.88	15	351	2009-01-15 18:05:59	2007-08-07 16:07:43	4	5	107	0	168	289	1	324.30	46	73.96	CHANGED	+s+tsh-pLpQKILcloEQl+lEQsARD-NVsEYLKLsss........ADKQQsuRIKQVFEKKNQKSApoIuQLpKKL-pYH++LKElEpss...........tppP+-sl+-hppuLK-sssp.p..........httl+s.hsGhS........hVhSKPREFAsLIRNKFGSADNIsphcs...............................s..Lc....shtsEp..ss+uLuuuu.ohsspsKYsSD-..-CSSsouu.Sssususps........................psstpsspsslstlhEELpEI+csQupLc-sh-sLKsphp+DashlspoLQEERYRtERLEEQLNDLTELHQNEhsNLKQ-LAohEEKlAYQSYERARDIpEslEsCQTRISKLE..pppQQQslQLEuh-p.pAR..sLLsKhINllLuLhsVlLVhVSTlAshssPLh+oRh+lhsTllhlhllshhW+pWcpl	.........................................................................................+.shspLpQKILKloEQI+lEQpuRD........sNVuEYLKLsss........A.DKQQ.suRIKQVFEKKNQKSApoIuQLpKKL-pY+++L+ElEpsG............cpsK-sh.+DhppuL+-stup................s+suhsuhS.s......................shVhsKsREhAs.LI..RN.KFG.SADNIspL+s.....................................................................s..h-....ph.s-t.......usps.hus.u..sh.s..psKYsS--...-C.SSsouu.Sss.us...uspu......................................tshh..tttthphlhcEl.pEl+cspspLp-shEsLKtp...hp+-.h...s....hh.psLQEERaRhER.LE-QlNDLT-LHQpEhhNLKQcLAshEEKlsYQuhERuRDIp.EslEsC.TRloKhE.......ppQQsl.........Qh.-shp.....A..+....sLLsKhINl...lL...slh.sVlLVhV.SThAphh.hPhh+o..........R.......+hhsThhhlhhlhhhh+pWtt.h............................................................................	0	31	46	87
+10100	PF10268	Tmemb_161AB	Tmem161AB; Transmemb_161AB; Tmem161AB; 	Predicted transmembrane protein 161AB	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3978)	Family	Transmemb_161AB is a family of conserved proteins found from worms to humans. Members are putative transmembrane proteins but otherwise the function is not known.	18.30	18.30	18.60	18.50	17.10	18.20	hmmbuild  -o /dev/null HMM SEED	486	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.81	0.70	-5.98	8	239	2009-01-15 18:05:59	2007-08-07 16:08:00	4	7	107	0	142	235	2	324.50	35	90.47	CHANGED	AllGlQLVVTLlhsSlhQKluPHaSFARWLLCNGSLhRYpHPTE-ELRsLAG..KQK..sK.u++-R+tNG....ssEsKPholPKDIDlcL-TpPlsshDsLsLRaFsEYQWLlDFuVYuslVYLlTElYahhhssscEhNISllWCLLVlhFulKlLhoLTsaYFpSEEG.GERSlCloFuFhaLLlAMlVLlVsEchLEhGLEsG...............asShssshpsFLcpQGLpsuu........PhoKLshKlhLAVhCuhLGAhLTFPGLRLAQMHLDALphspD+.hlQhLLHlSFLsPlllVlLWlKPIsRDaLpssshG+.SssLhSsssF-TLRLWlIllLCVLRhslhRhHLQAYLNLApcpV-QMKKEAGRIoslElQ++luRlFhYLCVVuLQYlAPllLsLahTLhLKTLGsaSW.GlhsEs...s..sh.ssscsuPlss....................t-s-t......phpsTstplpsuhuSL+slFTPllaRGlhuFLTWWlusC.FsoSLFGlaYHQYLstu	.................................hhhh.hhp+h...hhshhchllsps.Lhha.hPo..-ppLp.hss..........p.........p.tt.+p.p........pt............t..hplP+.sh....hpL.pp..l..h..Dhl..h..ha.p..h.ahh.h..h.s...hhlhhh...s.th.h..hh...................tp.....h..Nls..h.h.a.hhhsh.................a.s.h..p..h...l...hhp......................ps..hEpshhlshshh.hhlhuhhh..hhtcphh-hslp.u...............hs.shspsh...hhpppGh...t.....................P.h.sc.l......hh+h..hL.Ah.hs.uhlGuhhsF.PulRhAphah.......D....u.......lp.......h.....p.t.p.hhp......h..lLphsal.PhhhlhLWh..................+Pls+p.hlh...............................ht..t...........................l.......h....s......t.apphRlhhllhhshh+hhhh....hLQuYLshA.tth.p.+p.cuGpltshp....hpp.hl...hahYlsllsLQahs.Phlhh.l..hs.hhh.p....t....h.s...t...hs.h......................................................................................................................................................s....................................................................................................	0	45	63	105
+10101	PF10269	Tmemb_185A	Tmem185A; 	Transmembrane Fragile-X-F protein 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3879)	Family	This is a family of conserved transmembrane proteins that appear in humans to be expressed from a region upstream of the FragileXF site and to be intimately linked with the Fragile-X syndrome. Absence of TMEM185A does not necessarily lead to developmental delay, but might in combination with other, yet unknown, factors. Otherwise, the lack of the TMEM185A protein is either disposable (redundant) or its function can be complemented by the highly similar chromosome 2 retro-pseudogene product, TMEM185B [1].	22.90	22.90	22.90	22.90	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-12.19	0.70	-4.76	13	397	2009-09-13 05:38:14	2007-08-07 16:08:33	4	14	158	0	224	366	7	149.00	22	56.90	CHANGED	L+LDshlsWSaWhVFsPlW.haphllhhGuhlssss...........tspscahAhllulshpLlLlsFplLlC.pL.......tssshsWplVFlPL...a.hhpshulhthlhsh+a..............DcuhphphhahhshlphlF...........lhLKL......DsllshsWhlVFlPhaIshshthlhs................lahlhhsl.hhscs.plhsspccpphts.ulss......hhhslPhlsFpllLst+L-sss........plshhslFsPLhls	...............................................................................................................................................................................................................................................................hl.phlh.............lsL+L......-.p.hh.....h.....sWhh.l.........a.lPha.....lh.s..hhhl..hh.........................................hh..hh.h........................................................................................................................................................................	1	74	105	163
+10102	PF10270	MMgT	Tmem32; Tmemb_32;	Membrane magnesium transporter	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3918)	Family	This entry represents a novel family of membrane magnesium transporters (MMgT) [1]. The proteins, MMgT1 and MMgT2, are localised to the Golgi complex and post-Golgi vesicles, including the early endosomes, suggesting that they may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells [1].	21.20	21.20	21.30	22.00	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.34	0.72	-3.61	35	278	2009-09-21 12:36:32	2007-08-07 16:08:55	4	8	246	0	200	267	1	99.40	28	72.23	CHANGED	lhhlGhlhLhHuuYSuh..pa+phh+h.......sp......shssLPhDIllEsllulllhhhGllhsstph+.lph...............htclp....................pssaspl...............psRsuFhshpp+p+tht	..................h.hhlGhlhLhHAuaSuh..pa+shh+h....................spp......phpsLPlD.IllEslluhllshhGllhss.sch+slph.................ssclp...........................ppsassl...............pscsuFhshp++t+.h..................................	0	59	106	163
+10103	PF10271	Tmp39		Putative transmembrane protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3828)	Family	This is a family of conserved proteins found from worms to humans. They are putative transmembrane proteins but the function is unknown.	19.70	19.70	22.50	21.90	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.59	0.70	-5.82	11	215	2009-01-15 18:05:59	2007-08-07 16:09:16	4	3	90	0	111	180	0	321.40	44	87.45	CHANGED	uSuhGhSsPPlss..T...l+Hs.IP-lshs.upLlFEhhlFhapllALhlQYlNIY+TVWWhP.Sa..s+pSLNFHLIDapLhsFIslhLuRRLlasl......lpcsspuspsohhpplhhll....s+hslLThsshoLshohlpLF+saShlsLLFLsYPFshYlslhshph-.p.st...t..................ushhc.sp-ah.hLRchh+pp...ls.t..shPsHuCs......SPshIRsEV-tLKsDFNtRhKcVLFsSlLoAYYVuFlPshFVc..........................ss.YYDhhWoCpphlhVhluuhlhLhsaLLPs+YCDLLHRAAsHLGpWQ+l-......stssssspHsWS-pslWPQGVLV+H.s+slYKAlGhaNV....AlPu-sSHhRFahhFppPLRllNlLhslEsulllYQLaSLh.poccWppslSluLlLhsNYashFKLLRDRllLu+sYuh	.................................................................................................................................................................hss..s......pHs.hP-lshp.upllFEh.hFhh.llALhlpYlNIY+TVWWhP.sa..sppulNFaLID..lhhhhhlhL.uRRhlhsl.............l.ps...pts...t...ph.p.hhhhh.......h+hslh.shsthsL....s.h...shhpLapsaohlpLLaLsYP.hshYl.hhthp.-.....................................................................................ph..hlhp.....p.hcp....h.....shPsHsC.sh.....sPs.IRpEVEhL+hDFNhRhKclLhsS..........hhoAYYsuFlPhhFV...........................ss.a.aDh.hWus.phhlhV.lss.shhht.L.hP.sp...YsDl....L.H+uAhHLGpWp+l-.............s.hsss..tp.WoctshaspGslV+H.spslY+AhG..hsl....AhPussSHh....RFa.............hhF......ppPhhll..shLhhlpsullhhQlh.Lh.topcWpphlShullhFsNYhshFKLhRDhllht+hYp..............................	0	28	37	73
+10104	PF10272	Tmpp129		Putative transmembrane protein precursor	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3899)	Family	This is a family of proteins conserved from worms to humans. The proteins are purported to be transmembrane protein-precursors but the function is unknown.	21.80	21.80	22.30	23.20	20.90	21.70	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.12	0.70	-5.73	10	123	2009-01-15 18:05:59	2007-08-07 16:09:26	4	4	92	0	81	123	1	279.90	38	90.95	CHANGED	hChVFPPsEFhS.AGLTVpsLhStaLGSEDhuFVpYHlRRTo...ssLLsHShLPhGY....althshhAsppshhpstpss-........sWphhhhh.....uVllsllsuslsaYWSp+sWspHPlsKsLuhauhspu...sW+AVASuINTEFRR.-KFspthsu.o+VlVT-oWllKsTsYplclApQpDl+L..........................oVscS+pH-lo..sDsspslQhlsIpVsshsPt.lcPFsIRLNus-Yt-LpE+LcsPIpssuNVslHpols-cFlEsF+upVctNssaphs...sspEhEPCluCMQspssIKltKpC.sp-p....pG.......cCQsCYCRPMWCloChuKWFASRQ..Dppc.-TWLuu+ssCPTCRA+FCIhDVChl	................................................................................................shlasPpEF.t.hGhTlpplh..utaLGpEphsFl.aHl+Ros...hslhhHohLPhuY....hhthp.hhstpp..h........t..............aphhhhh.....ulh.h.shhsshhha..h.Wp..ppWtpHPls...+sLthas..s..t...................sapsVAssINsEaRch.D+aththsu.u......pllsT-sWlhKsosY..plphApQpDspL..........................sVscucpaplo...-.....ss...slQh....lsIpVt..s.........hpst..lpsFsI..Rlsuh-atpLp-+lptPIt.s.tsl.h+.pol.-hFl-sFtp.VthNshaphs.........................t...ph-.ChuChp..ttsslKl.K.C.p.st........tG.........pCppCaCRPMWC.......lpChu+WFAuRQ..s..c.....-.hWLtu+ssCPhCRupFClLDVshl.................................	0	34	39	63
+10105	PF10273	WGG		Pre-rRNA-processing protein TSR2	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4032)	Family	This entry represents the central conserved section of a family of proteins described as pre-rRNA-processing protein TSR2. The region has a distinctive WGG motif but the function is unknown.	21.90	21.90	22.10	22.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.56	0.72	-3.89	34	320	2009-01-15 18:05:59	2007-08-07 16:09:44	4	7	273	0	236	319	3	83.20	33	40.01	CHANGED	hFppulshllppWsuLplAVpNs.WGGscSp-Kp-hlsstlh-hFss....................................spsh-..tp-lE-hLhphMt-EFss.slEDsSshpVApt	.........FptulphhlppWsuL.plAV-Ns.WGGs.....p..S..pcK...t-alss.slh-.hFtp..................................................sp.s.sc..hp-lE-hLhphMssEFcs..lEDsSh.pVAp.........................................................	0	78	130	195
+10106	PF10274	ParcG		Parkin co-regulated protein	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3961)	Family	This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system [1].  Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.27	0.71	-4.38	21	338	2012-10-11 20:01:01	2007-08-07 16:13:17	4	16	140	0	236	318	11	152.70	38	43.48	CHANGED	opFRthYsRGDlPlplpHuust....pc..ltW..+lsscpLDYc...hYLPlFF-GLpEpcaPYpFlAppGsh-LLpp............utpKIlPllPpLIlPlKsALsT+c.clhpssLclLQpLVhsushlGtALVPaYRQLLPlhNhapt..+p......hNhGDtlca.....cpppsluDlIp-TLchLEcpGGsDAaINIKYMlPTYpS	......................otFtthYp+GshPhtl.assht......pp..ltW...........cs......c..pLs...ac...hhLPlFh-GLpEhppPYp..FhAtpGhp-hLtt............uspK.llPllPpLIhPlKs...............ALsp+s.plhptsLpsLppL.........u...p..........hlG.tALlPa..aRQl....Lshhshhhs...hp....................................s...u.p.h........ptpppht-lIppTLphhE.hG.........G...s...uhh.IK.hlPTYpS............................................	0	104	134	186
+10107	PF10275	Peptidase_C65	Otubain; 	Peptidase C65 Otubain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3991)	Family	This family of proteins conserved from plants to humans is a highly specific ubiquitin iso-peptidase that removes ubiquitin from proteins. The modification of cellular proteins by ubiquitin (Ub) is an important event that underlies protein stability and function in eukaryote being a dynamic and reversible process. Otubain carries several key conserved domains: (i) the OTU (ovarian tumour domain) in which there is an active cysteine protease triad (ii) a nuclear localisation signal, (iii) a Ub interaction motif (UIM)-like motif phi-xx-A-xxxs-xx-Ac (where phi indicates an aromatic amino acid, x indicates any amino acid and Ac indicates an acidic amino acid), (iv) a Ub-associated (UBA)-like domain and (v) the LxxLL motif.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.95	0.70	-5.02	33	450	2012-10-10 12:56:15	2007-08-07 16:16:48	4	8	244	24	284	557	7	211.80	28	59.13	CHANGED	pttsphPh.luph....tshssLtcEYspt.sssahpKh.........ptLppp..YsthRpsRGDGNCFaRAhsFuYlEhLLppps......chsc.hhpplp..phpppLh.....thGhschhhcDFh-thhpllcplpstspts.......pllptasctstSs..........llhahR..hlsSualpppsctapsFl.t.........holcpaCppplEshtpEuDcltItALupuL....slslcVhYlD..............................ps....ssspsspash..................p....................ttshI............hLLYRPGHYDILY.	............................................................................h.lut..........l.t-a.t....s.......hh.tKh..................ptLtpp....ashhRps+sDGNCFaRAhhauahEtLlpptc......................chpc.hhthh.t...p.pptl............................thGa...tph.h..h.csF.hpthhpllppl...tpttp.s.................pLhp.h..Fs.cp.s.h.Ssh.............................llhahR...LlTSualppps..c...h......a.p...Flps...................hslcp..aCp...ppV...-shtp....Es..Dcltl..hALspAL.............slslpl...Y.hD..............................ps...........tssths.a.hs...............................ts................................ststl............hLLY+P.G.HYDILY..................................................................................................	2	105	150	216
+10108	PF10276	zf-CHCC		Zinc-finger domain	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG3456)	Domain	This is a short zinc-finger domain conserved from fungi to humans. It is Cx8Hx14Cx2C.	21.20	21.20	21.20	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.29	0.72	-4.11	37	906	2012-10-03 19:45:42	2007-08-07 16:22:25	4	3	865	3	386	717	277	40.00	35	42.20	CHANGED	ss+plsC-G..........us.....ss......hGHP+Valslsppst...hhCsYCup+ah	...................................h.CsG..........st.....ss......huHP+Valslsc.psp....stCsYCGphah......	1	115	224	304
+10109	PF10277	Frag1		Frag1/DRAM/Sfk1 family	KOGs, Finn RD, Coggill PC, Bateman A, Wood V	anon	KOGs (KOG3979) & KOGs (KOG4320) & Pfam-B_15139 (release 21.0)	Family	This family includes Frag1, DRAM and Sfk1 proteins.  Frag1 (FGF receptor activating protein 1) is a protein that is conserved from fungi to humans.  There are four potential iso-prenylation sites throughout the peptide, viz CILW, CIIW and CIGL. Frag1 is a membrane-spanning protein that is ubiquitously expressed in adult tissues suggesting an important cellular function [1].  Dram is a family of proteins conserved from nematodes to humans with six hydrophobic transmembrane regions and an Endoplasmic Reticulum signal peptide. It is a lysosomal protein that induces macro-autophagy as an effector of p53-mediated death, where p53 is the tumour-suppressor gene that is frequently mutated in cancer. Expression of Dram is stress-induced [2].  This region is also part of a family of small plasma membrane proteins, referred to as Sfk1, that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, thus allowing proper localisation of Stt4p to the actin cytoskeleton [3-4].	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.49	0.70	-4.86	89	980	2012-10-01 21:22:51	2007-08-07 16:52:53	4	16	284	0	645	961	31	204.50	18	57.40	CHANGED	shth....lslhtslhshsshlhshhhuhh..p.hhphs...........................hP.ISs..hGshsPcptlaphhhslsuhhthhlhhhtahh...............................................hhthhppt.....................lshhuhhhGllss.lulshluhh......sssptt.slHhhhhhhahshshlahhhpshh.hhht............................................ttphshth+hhhshhshshhlsh.................hhhhhhpphh........................hhshsAhhEWhlshhhhhah.hohhhDFtsh	..........................................................t...hlshhhshhshsshhhs.......hhhuhh..p..hh.p..s...........................................................................hP...l......Ss..hG....shs.P.pphlathhhshsuh.h...........t.hhhhhhhath.....................................................................hht..h...pp.t........................lshhshhhuh.lss...hul.hhlu.h.....................................ppsp......h.....s..........l...H....h.hh.hh..hhssshhahh..hpshl.hhht.............................................tth..hs.hhh+...h...h..hhhht.hh..shlhh...........................................h.h.hh..httt...............................................hhshhAhhEWhlshh.hhah.hohhh-Ft..h......................................................................................................	0	196	297	503
+10110	PF10278	Med19		Mediator of RNA pol II transcription subunit 19 	KOGs, Finn RD, Coggill PC	anon	KOGs (KOG4043)	Family	Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators [1].	25.00	25.00	26.20	26.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.35	0.71	-4.60	7	119	2009-01-15 18:05:59	2007-08-07 16:53:34	4	5	92	0	79	112	0	161.60	53	58.81	CHANGED	uPFYLh+.E.Ps.sELTGspNLlscYsLEpuasKFsG.KKVKEpLSsFLPcLPGhIDhsGo..-NSSLRSlIEKPPIsGpph.PLTus.LsGFRLHsGPLPEQaRhh...+hp.Pp+KpKpKHKpp+sp-...shs............tpossDo......-+K+KKpK.+-DD.-RKK+KK-KK+KKpR+oP-p.ssG.	...................................................tPFYLh+..E.P...u.p.sELTGuTNLloaYsLEcuY...sK.FCG....KKl.KEcL..S..sFLPcLP..GhIDhPGsp.D.NSSLRSLIEKP.....PI.hG..pshsP.lTushL....s.GFRLH...s.....GP...LPEQ..hRhh.........................chp.Pp+K..p..KpK...HKpp+ppD....sss...................p.ost.Ds.......-.+.K+KKpK...+c-D..-..RK++KK...-..KK+..KKp.+cosc..s...s.........................................	0	25	31	58
+10111	PF10279	Latarcin		Latarcin precursor	Bateman A	anon	Bateman A	Family	This family represents the precursor proteins for a number of short antimicrobial peptides called Latarcins. Latarcins were discovered in the venom of the spider Lachesana tarabaevi [1]. Latarcins are likely to adopt amphipathic alpha-helical structure in the plasma membrane.	25.00	25.00	25.20	33.40	24.90	22.60	hmmbuild  --amino -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.80	0.72	-3.79	7	14	2009-01-15 18:05:59	2007-08-08 11:04:13	4	3	1	2	0	16	0	66.10	32	75.41	CHANGED	TuYsVsE-LEs.ELD-L-............................ttuh.......................................................................................LtchsEsLc.l-Dh.p.EEARu.hhthhKcchKchhpphhc+h	.puYsVsE-l-spEL--hpttuh...............................Lt-hsEpLctlpsh.p.EEARu...t.h+chh+phhtthhph..	0	0	0	0
+10112	PF10280	Med11	HSPC296_Med11; 	Mediator complex protein 	KOGs, Finn RD, Coggill P	anon	KOGs (KOG4507)	Family	Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organisation is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans [2]. Med11 appears to be necessary for the full and successful assembly of the core head sub-region [4].	25.20	25.20	25.40	27.30	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.40	0.71	-4.05	25	234	2009-01-15 18:05:59	2007-08-09 09:12:30	4	2	208	15	169	229	0	118.80	24	78.35	CHANGED	sp-RLcuLs-IDpcIsplLppAupslppLup.pp........................ts+pthpppsppFhpoLspVsspLR+pIphL--ssss.scptssh....................................................................tsLsls.lsp+psshs+c+LpEhhpp.hcphls	.......h.t-RlppLscI-+.....cIsp.lLppAupsltpLuppps.......................................pp..pthcpp...sppFh.pslp.p.l-scLpcQIphLscsshhpscpsssh................................................................................sshcs.s.hsh+p.hphs+p+hs-lhpp.hpph.....................................................	0	42	81	131
+10113	PF10281	Ish1		Putative stress-responsive nuclear envelope protein	Wood V, Coggill PC	anon	Pfam-B_11056 (release 21.0)	Repeat	This family of proteins found in fungi is a putative stress-responsive nuclear envelope protein Ish1 [1].	24.10	24.10	24.10	24.20	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.60	0.72	-3.86	71	642	2009-01-15 18:05:59	2007-08-09 14:52:20	4	9	141	0	466	616	0	37.40	36	30.74	CHANGED	acsWos..scL+paLcp....aGl.sspst......s+-cLlpts+csh	.....a-sWSc..ocLKpaLcp....pGlssspss......pR-cLlsts+cp...............	0	129	251	391
+10114	PF10282	Lactonase	DUF2394; Muc_lac_enz;	Lactonase, 7-bladed beta-propeller	Wood V, Coggill PC	anon	Pfam-B_1372 (release 21.0)	Family	This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type (EC:3.1.1.31) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase (EC:5.5.1.5) and muconate cycloisomerase (EC:5.5.1.1), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway.\	\	    Structures of proteins in this family have revealed a 7-bladed beta-propeller fold [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.00	0.70	-5.37	81	4118	2012-10-05 17:30:43	2007-08-09 15:02:03	4	86	2565	28	1191	3490	508	268.50	22	71.36	CHANGED	phalGoYTp..............ttupGIathpl...sspoGpLsshph.ss.....phssPoaLsh..ptssphLYulscts.......spGulsuaplsspp..upLphls......ph.s..tGssPsalulstssphlhsANYt.......uGslsVaslssc.Gslttssp.hhppp......Gs..GPp............pcQcssHsH.sshoPcscallssDLGsDclhhYch...sssst....Lst...hsph.pstsGuGPRHlsFps...s...................sphAYllsELuupVslh..pYs..tsG..ph.pplpslsslPt..s.hsup.....................s...tuAuI+losDG+FLYsSNRG...................psSIulFslstssGpLphlpthsotGph..PRcFsl.sssGcaLlsusQcSss.lslapRDspoGpLs.hsps.htsspPs.................sVhF	.........................................................................................................................h...........................ttl..h.h.......t....t..t...t..ht......t...h................t.s.t....h.....h...h...........t..........t...t.h...l.ash..t.....................th..sh.t.ht..............t...hs..................t..................st......s.a.l..s..h...t....t..t.p..h...lh.....s.....u.s...Yt........................tu..h...h.h........htt...u...............................................................................................................s...ts....H..h....h.sP....s....tp..hl.h.s....s....s....L......t................D.p......lhh...ap.h....sttt.............h............h...th.......G.s....G.......PRHh...s.Fps.........s...................................................tph.hYl.h..s..E...l...s.....ss....lslh...........phs.......ps...............ph....p...h...p.p...hs...hhst......s..hsst.................................................p......tsu.s.l..p..l.....o.....s.....D.....G.....+.....a.....L.Y.s..us.Rs............................................tss...l...u..l..a....s......l............t....s...s........s.............p...............L....p.....h...l.....t..h..........h.........s......o.....t.....G..p......................P........R.........s......h.....s...l......s........s......s..............u.....c.....hL.h.....s......ss.p...p..o................s...s....ls..la..p..h..s.....pp.G.....lt.................ts............................................................................................................................................	0	394	731	968
+10115	PF10283	zf-CCHH		Zinc-finger (CX5CX6HX5H) motif	Wood V, Coggill PC	anon	Pfam-B_93850 (release 21.0)	Domain	This domain is a zinc-finger motif that in humans is part of the APLF, aprataxin- and PNK-like forkead association domain-containing protein. The ZnF is highly conserved both in primary sequence and in the spacing between the putative zinc coordinating residues and is configured CX5CX6HX5H. Many of the proteins containing the APLF-like ZnF are involved in DNA strand break repair and/or contain domains implicated in DNA metabolism.	25.10	25.10	26.40	26.20	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-6.99	0.72	-4.10	22	261	2009-01-15 18:05:59	2007-08-09 16:02:15	4	30	96	6	185	282	0	25.50	48	7.07	CHANGED	PcC.YGspCYR+NPtHhpcasHssps	...pC.YGspCY..R.KNPtHhpcasHPs.......	0	82	94	142
+10116	PF10284	Luciferase_3H		Luciferase helical bundle domain	Bateman A	anon	Bateman A	Domain	This domain is found associated with the the catalytic domain of dinoflagellate luciferase . Luciferase is involved in catalysing the light emitting reaction in bioluminescence. The structure of this domain has been solved [1]. This domain has a three helix bundle structure that holds four important histidines that are thought to play a role in the pH regulation of the enzyme.	25.00	25.00	26.60	58.10	18.30	16.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.38	0.72	-4.02	7	51	2009-01-15 18:05:59	2007-08-09 16:29:47	4	3	14	1	0	49	0	65.80	70	21.82	CHANGED	CEK.GFEsusssKGGALsAtpVE+hG.-sFKsGLHpPpFHs-GLHKPhEuGGKsYETGFHYLLEsHE	CEKTGLEuGGsu+GGALNAAQVtHLGc-sFKsGLHKPcacsEGLHKPHThGGKTY-TGFHYLLEAHE	0	0	0	0
+10117	PF10285	Luciferase_cat		Luciferase catalytic domain	Bateman A	anon	Bateman A	Domain	This domain is the catalytic domain of dinoflagellate luciferase . Luciferase is involved in catalysing the light emitting reaction in bioluminescence. The structure of this domain has been solved [1]. The core part of the domain is a 10 stranded beta barrel that is structurally similar to lipocalins and FABP [1].	25.00	25.00	46.90	46.40	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.82	0.70	-5.25	3	71	2009-01-15 18:05:59	2007-08-09 16:40:55	4	4	18	1	0	69	0	174.50	64	66.51	CHANGED	PLCKDPYGPEVpuLVEsLL+EApDD+TLCF-NFpcPCPQLTKEQVAhCKGFDYGDKTLKLPCGPLPWPAGLPEPGYVPKTNPLHGRWITVSGGQAAFIKEAIKSGMLGAAEAHKIMADTDHHQTGGMYLRINQaGDVCTVDASVAKFARAKRTWKSGHYFYEPLVSGGNLLGVWVLPEEYRKIGFFWEMESG+CFRIERRAFpsGPYMFLRQATEVAGKISFVFYVKVSNDPGSKPIPLQSRDYTALAGpDNVPDNLGKPYsCTAKDLDYPpKRDuWLDpNKcpMLcQR-lVuoAF	...........PLCtDPautElpslspsLLp-AppD+TLsasNFpDPCPpLTKcQVt........sKthpLPCGsLPWPAGhP.PsYVPKTsPLpGRWITlSGGQttFIKpuIcsGMLGtuEApKIhADTDHcpTGGMaLRINQhG-.CTVDASVAKaARAKRTW+SGHYFYEPLVsGup..GVhsl.EEY+pIG...................................................................................................................	0	0	0	0
+10119	PF10287	DUF2401		Putative TOS1-like glycosyl hydrolase (DUF2401)	Wood V, Coggill PC, Bateman A	anon	Pfam-B_11571 (release 21.0)	Domain	This family of proteins is conserved in fungi. One member is annotated putatively as OPEL, a house-keeping protein, but this could not be confirmed. It contains 5 highly conserved cysteines two of which form a characteristic CGC sequence motif. It has recently been shown that this family is related to known glycosyl hydrolases [1].	21.50	21.50	22.70	21.60	21.10	20.10	hmmbuild  --amino -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.70	0.70	-4.88	39	173	2012-10-02 19:29:29	2007-08-10 10:30:32	4	7	100	0	120	172	22	219.60	41	50.78	CHANGED	uusWsRsuYY...osuou-NlTFLNptGu.tuSGsaSssaGsSLSYAsocGsuuASSspsLs.-sh.............lsSspEasIaSsppCsss....sCGaYRpG.IPA.....YHGFuGssKhFlFEFpMPs.sssssu..hshDMPAIWLLNA+IPRThQY....ssssCSCWp....oGCGEhDlFElLsuusc...+LhSplHshQG.ss....ssGuGsssYFpRPTs..uohKuuVlFsusss....lplltl.s-shsFssolsussVpsWl	..................................................usWsRhuYY.ps.ssuos-NloFLNptGu..ttSGsho.sshGsuLS.YA..suDG..s...uuAuospsLs.ssh................lsSspEahIhSsppCsss.....sC.GaaRtG.hsA.....YHGFsGssKhFlFEFpMPp.spssou.........hs.DMPAIWlLNA+IPRThQY....spss..CSCWt........oGCGEhDlFElL....sussp...+hhSphHshQ........thusGspsYFpRPos..uohK.suVlFsusss.....lplltl.s-sh.sFs.s.olssssVsph...........................................	0	25	66	105
+10120	PF10288	DUF2392		Protein of unknown function (DUF2392)	Wood V, Coggill PC	anon	Pfam-B_10085 (release 21.0)	Family	This is a family of proteins conserved from plants to humans. The function is not known.  It carries a characteristic GRG sequence motif.	27.30	27.30	28.40	28.00	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.22	0.72	-3.71	35	268	2009-01-15 18:05:59	2007-08-10 11:46:09	4	8	242	0	195	274	0	104.40	28	23.31	CHANGED	LAsclLutlsKGRGuulshpls.sssp......tclphlhPLRDlltpElphYsphttls.h.hs...hhhp................tpphscshoIpcLsppalpsLpps.aPSssSTVlRTusKL	....................LAhchlstlshGRGttlshp.....ss.sspp.......................tslhllhPlRDhhtpElshYsp.ht.s..l...phhhs....hh.t....................................................psscstSIpcLhppalpslppp.aPusluTVhRTusKL....................	0	57	100	160
+10122	PF10290	DUF2403		Glycine-rich protein domain (DUF2403)	Wood V, Coggill P	anon	Pfam-B_11570 (release 21.0)	Family	This domain is found in the N-terminal region of members of DUF2401 Pfam:PF10287. The function of this glycine-rich region is unknown.	20.90	20.90	21.70	22.20	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.13	0.72	-3.82	26	164	2009-01-15 18:05:59	2007-08-10 15:40:59	4	7	97	0	113	155	1	64.50	42	14.41	CHANGED	scplpas....NVG..aSGoYpsVopMspto....C...sC..spsshpFSGslAPlsEcLSVHFRGPLpLpQFAVYhPs	......................ptl.Ys....NlG..hoGoYpcVosMppts........s.....sC...sppshsa..SGsluPLsE......E..LSlHFRGPlpLhpFusYhs............	0	23	62	99
+10123	PF10291	muHD	SAFF;	Muniscin C-terminal mu homology domain	Yang H, Coggill P	anon	Yang H, Pfam-B_7632 (release 21.0)	Domain	The muniscins are a family of endocytic adaptors that is conserved from yeast to humans.This C-terminal domain is structurally similar to mu homology domains, and is the region of the muniscin proteins involved in the interactions with the endocytic adaptor-scaffold proteins Ede1-eps15. This interaction influences muniscin localisation. The muniscins provide a combined adaptor-membrane-tubulation activity that is important for regulating endocytosis.	25.00	25.00	25.10	25.40	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.99	0.70	-5.20	32	429	2012-10-02 01:13:52	2007-08-10 17:13:25	4	5	231	1	244	384	2	258.90	34	33.14	CHANGED	.GLsASlsEslsAhF+sGtlsc.............splsGElALsYsus.sss.......s..........tshslRlsNhpplEKVhsNppal..........pppss.......sc...aplshstlsspo.hsu.............hKYpl+hp.......s.sPlhlpssW+hEsppsulhlpYphNs....uhsss.....lsLpNlslsVsl-su..............psTus.o.cPp..usas+EppplsW+hs-.lslssps...t+LlARF.ssssss.........p.usVps+Fphc.ssshpt.......lslshh..............t...P....................s..ap.s.spRplsuG.p..............Yhup	..........................................................hslssuhsEsVsAaF+susso+.............l+ls..GEhsloFPuuhsphhss............sP...........ssLsFR.l.........p.Nhu.p..LE+..lhPNspLlhp........sspss...............sp..........Fhl.NhssLtst.LppsuptpPtu.................................aaNlshLKYQlp....sps................pssPLpLsshW+s.csspTslpl-Y+hNsp......uhsss...............ssLpNlpllVsl..-Gu...............sTshp.u.hPs...AsW..stEpp+lhW+ls................-...lo.pucst....GpLh...ARFphspuss..........pPusl..s....spFssc.....u...so..LSG.........hclpLs......................................................Gssa+h..s.hl+++hssG...+Yhu.s............................................................................................	0	56	99	180
+10124	PF10292	7TM_GPCR_Srab	Srab; 	Serpentine type 7TM GPCR receptor class ab chemoreceptor	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srab is part of the Sra superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2]. The expression pattern of the srab genes is biologically intriguing. Of the six promoters successfully expressed in transgenic organisms, one was exclusively expressed in the tail phasmid neurons, two were exclusively expressed in a head amphid neuron, and two were expressed both in the head and tail neurons as well as a limited number of other cells [3].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.13	0.70	-5.74	17	186	2012-10-03 04:04:29	2007-08-10 17:28:29	4	4	10	0	183	384	0	249.20	17	86.59	CHANGED	ppsCphMtpluoStaL+hoLhhpLllsllulPlhlhu...laphppspLFHhNh+lIhphHhhuhhlHshuRlhLHuhDLaNYhs....hssC-hhPshhRChllRhhYshGhalsssTslsLlIERhlAThpuspYEpptphhGlllshhQlsluhhhhhhhapphsF....sshh.YChshpsu...sh.hplshhlslhsQlluhlhFtaLh+hNc+lRs..tphpuoLSsRYQLEQNlpShpsL+hFushshlFlhhphhhhhhlhhhutphppspYhAllElstshPlYullhhhhlh+p.+c.+schppsLpsphphstsp...YF-papc...pls	..............................................................................................................................h..hhhs.hh.s.h....h.hh....hh......t.h.h..H.N.hphl.h..hhhh......h....h.lh..sh.................h....h...h...............h........h.h....hh.............p.s.p.h.h........t..h...............hC..........h.hhRh.h.hu..........h.h.h.......s.......th.o...hh..h..l.....h.....lERh..............lAThh...pp.Y..E................p.p.t..t....h.h...G...h.hl................s.h...............hp..hh.l.uh.h.h.h.h...h.hh..t...t.h.............t.hh...a....C....h.....................t..s..........h.....h....hh..h.h..h..hh.p..l.hs.h...h.h..h.........h.........h..l.h....t.h.N.p..................p....h....p....................t...sLop........+......aQ......lppNh..............p.shp.h.l...h........h.h..hp......h..hhh..h.....hh...h.h.h..h........h........................................h......................................................s...........h...h..................h.........................................................................................................................................................................................	0	64	90	183
+10125	PF10293	DUF2405		Domain of unknown function (DUF2405)	Wood V, Coggill PC	anon	Pfam-B_12420 (release 21.0)	Family	This is a conserved region of a family of proteins conserved in fungi. The function is unknown.	20.20	20.20	20.30	20.20	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.75	0.71	-4.49	32	202	2009-01-15 18:05:59	2007-08-13 10:57:13	4	25	165	0	156	211	0	159.50	26	6.23	CHANGED	hpschlRlhscuPplcp..hWsRllslpsh+lshc..phcpp....................lslps-sl+lslPHpalhaplhDNlssshKulKQLptph+s.....sssch....lhs+p..pstplP+lsl+octlhaplEDDPFEpcLuhIYclGllEQ+pRLp+.ptFct+spclppsspppt	........................................................................................................h...p.hRhhstsPthpt...hW..scllslpshclshc.tptpts.............................t.hslss-sl+ltlPachhha.clhDN.hlshhKulKpLhapaKs........ss.ch.......lhspt..tPptlP.clsl+s+phhh-lEDDsFEh+LuhIYclGl.EQ+pRLtR.ptFctKlpclpptp...p..........	1	42	83	139
+10126	PF10294	Methyltransf_16		Putative methyltransferase	Wood V, Bateman A	anon	Pfam-B_19672 (Release 21.0)	Family	\N	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.08	0.71	-4.81	15	2584	2012-10-10 17:06:42	2007-08-13 15:02:31	4	72	442	2	1819	5419	1399	156.00	21	50.49	CHANGED	hhcss.LpIpE-sus.ulutplWDAulshshYLtpt..tt............tspphsshslLELGSGsGlVGlulAth....h.ssssVhlTDl--.hh-lhcpNIpl..t...hlssclpscsLcWG-.cL.s-hhssp.hDLILsADClYhEcuhssLlpoLpcLssssss..lLhuaK+R.....+cu-ppFFphlcct	......................................................................ht...........................h...G.h.h.l.W.s....uuh.....hL....u...p.......a.l.p................................................................t.t....h.psp.p.l.l.EL.....G..uG.s.G......L..s..u.ls.suhh.................................ss.p.V..h...h.T..D.......h....s...p........h.....l..p....................l...p...t..........N.l....ph...N....t............................t...s....p.......l.......p............s........t...............t....L..........p.......W............s.......p............................h...............................................p...............h..............................t..............................t...........................h..........D.............l...........l..........l...u...u....D....s....l...........Y.....................p.......h.....h.............Lh...p...s...l...p...t.h...h......t.........t.t..................h.hh.s.........t........................................t........................................................................................	1	693	1089	1500
+10127	PF10295	DUF2406		Uncharacterised protein (DUF2406)	Wood V, Coggill PC	anon	Pfam-B_13850 (release 21.0)	Family	This is a family of small proteins conserved in fungi. The function is not known.	21.10	21.10	22.90	53.60	17.60	16.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.61	0.72	-3.46	18	139	2009-01-15 18:05:59	2007-08-14 10:52:48	4	1	105	0	94	127	0	69.80	52	25.28	CHANGED	AlpEAQPappAh.......htpppstphpstpc............+DhaGpsIs................................................pPDhSNPTRsR.ERPLDTIRuFEhAIsG	.......................................AlpEAQPh.ppAh..................pppht.hps.p+..................+DhaGpsI..s................................................pPDlSNPTRsR.ERPLDTIRuFEhAIsG...	0	13	43	76
+10128	PF10296	DUF2404		Putative integral membrane protein conserved region (DUF2404)	Wood V, Coggill PC	anon	Pfam-B_12178 (release 21.0)	Family	This domain is conserved from plants to humans. The function is not known.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.82	0.72	-3.85	32	588	2009-01-15 18:05:59	2007-08-14 14:30:48	4	15	262	0	414	579	1	90.30	24	12.53	CHANGED	NAllGRlFhshh+opthpshltpKIpKKLs+l+...pPsFl.scltlpclDhGsssPhlosspl.plsscGphhhs.............hslpYpG.......shplplpTphsl	............................Nslluphhhphhpss.h.h.....ps....hlppplpcpLs.clp.....hPsal..sclpls-lshGsssPhl..pss.c.l...h..t....l......s........t....p.G........hhhc...............................h-lpYsG.......shplslpophp...........................................	0	130	232	350
+10129	PF10297	Hap4_Hap_bind		Minimal binding motif of Hap4 for binding to Hap2/3/5   	Wood V, Coggill P	anon	Manual 	Motif	In Saccharomyces cerevisiae, the haem-activated protein complex Hap2/3/4/5 plays a major role in the transcription of genes involved in respiration [3]. Hap4_Hap_bind is the essential domain of Hap4 which allows it to associate with Hap2, Hap3 and Hap5 to form the Hap complex [2].	21.10	21.10	21.50	21.80	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.05	0.73	-6.22	0.73	-3.92	11	175	2009-09-10 17:07:33	2007-08-14 17:00:41	4	3	128	0	121	171	0	16.90	77	3.20	CHANGED	sSKcWVLPPRPKPGRKP	...TSK-WVlPPRPKPGRKP...	0	29	67	104
+10130	PF10298	WhiA_N		WhiA N-terminal LAGLIDADG-like domain	Mistry J, Bateman A	anon	Manual	Domain	This domain is found at the N terminal of sporulation factor WhiA. This domain is related to the LAGLIDADG Homing endonuclease domain while the C terminal domain of WhiA is predicted to be a DNA binding helix-turn-helix domain [2].	23.40	23.40	23.40	23.40	23.10	23.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.47	0.72	-4.14	74	1805	2012-10-03 01:41:40	2007-08-14 17:02:56	4	4	1794	3	299	986	93	85.90	33	27.65	CHANGED	pssppA...ELuAllRhsGuLpls..spp.lslclpT-ssulARRlapLl+cha.slpsElhVppptpL+K.sshYlVpltps..spplLccl.sll	................t..pt+AELuAllRhsGuLsls.....sp.......p....lslslpTENuslARRlaphlcchY..slpsElhV+p.+hp.L+K..NshYl.VRlspp....spclLp-Ltlh.............	0	110	208	263
+10132	PF10300	DUF3808	Deme6; IML2;	Protein of unknown function (DUF3808)	Wood V, Coggill PC	anon	Pfam-B_15386 (release 21.0)	Family	This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain Pfam:PF07719 at their C-terminus.	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.47	0.70	-5.93	20	568	2012-10-11 20:01:01	2007-08-15 15:32:33	4	21	235	0	370	612	25	413.60	24	75.08	CHANGED	hpAlsLhLsschp-AhshLc...h...sspShaH.uLGtusltalpAhlTFEscchppAsssL+cAppssp+.Rc+uphhs.............t..h....phht..thctplCYAEshLh+AsLsF.hsEshlshIKGuhKlR+uYphYc-hhphhpth....................................................................................................shtps.........psccalcuGVphGhGlFpLhlSLlPspll+LLphlGFpGsR-hGLptLhc.uup.scsl+usLusLsLLhYashlp.hhuh.............................tphshccs-plLt.hpppaPpuulaLFacuRlptlpGpl-pAlphhcpsh..tsppchKQl+pLChaElhashsappcacpAhphhhhLhcpScWS+AhYsYhpushhshhscp............-ttstt.-ptsplhcplssLtt+hth..KslPhE+FshRKsp+apup..p............shhssPshEhhYhWNGashhuccth..puhhphh.p...............p.pp........D-ps.....lhpLL+GlsL+pL	...............................................................................................................................................uhthhhssphptu.thhp................................tpps.............hh...s........hshuhl.hhp.Ahh.sF..-..................pphp..Ahpthpps...phst.t..pcpsphhp.....................................t...h.......tth.h.....t.hchplshA-s.l.p.Ahlsh...pps..h..hthlKuhhplRpuathh..p..p..hhp.lpt............................................................................................................................................................................................................................p...hhcuGlphshGhhpLhlShl.Psplh+llphlGFp.G...........s+phGLp.L.....h.....p...u...............s...............p..tpsh+usls.slhLLh..aashh..hhsh.........................................................................................thshptscplL...t.hhttaP......p.us...la...hh.puRhthhcsp....lp...pAlphhp.psh.....p.........................p.p......p......h+................Q..........h..p..t...ls.h.a.E.hhhs..hh.hpapt...A...h...h.....h.Lh.p....s.p.W..S..+.......u.hYhYh......tu.shh..hhc.........................................................cph.plhp.ps............ssh........h.......t.+hth........+sh.Ph-pFsh.+Ksp........+a.tpt..............................hhh..shhEhhYhWsuhthhstp.......shh.h............................................................................Dp.s..........lh.lLhuhhh+..................................................................................................	0	129	181	279
+10134	PF10302	DUF2407		DUF2407 ubiquitin-like domain	Wood V, Coggill PC, Bateman A	anon	Pfam-B_17915 (release 21.0)	Domain	This is a family of proteins found in fungi. The function is not known. This domain is related to the ubiquitin domain.	25.40	25.40	25.40	25.50	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.50	0.72	-3.80	46	152	2012-10-03 10:59:06	2007-08-15 16:09:52	4	4	135	0	111	189	0	115.20	28	33.54	CHANGED	hhlsIRFos......slPD...l.LsIs....s.ss.sTsstLKp...........................................hIRpcl..........sp.......hss+RLRLIa.......sG+h.Ls.-ssslssplphs........................................................ptpupts.p.................+h.YlHCslG-.	...................h.hlsIRFos......ulPD...l.LsIs......sssp..sTsttLKp...........................................hIRppl.......................................s.p.......ssp+RLRLIa.......sG+l.Ls.Dsoslusplph.....................................................................t..p.ptpupss.t....................................phYlHCslG-.................................................................................................................	0	27	58	92
+10135	PF10303	DUF2408		Protein of unknown function (DUF2408)	Wood V, Coggill PC	anon	Pfam-B_16841 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is unknown.	25.00	25.00	45.80	25.00	24.10	24.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.89	0.71	-4.04	22	259	2009-01-15 18:05:59	2007-08-15 16:25:05	4	4	128	0	202	255	0	114.90	31	47.36	CHANGED	plcplss-LtshapcLlsIRRslhshsopsKhs.....................................ssclppLpppLccl-spR..hDG...cFhus-.....sphlps.QsllsGLLDcChphhpDl.tccs......................pls.phpshYcpLl-I+sp.LEpLhlT+RWTLRE	................................s..-.lotsL.PlappL.ol+RsLhplpppuths.......................................................................spELhshphcLppIDshR....sDG.............KFhsss.............tph..t.QuhlssLLscCaclsp-lptptt....................................................................................................	0	58	117	174
+10136	PF10304	DUF2411		Domain of unknown function (DUF2411)	Wood V, Coggill PC	anon	Pfam-B_15078 (release 21.0)	Domain	This is a 38 residue domain that is found in proteins at the extreme C-terminal end of some HEAT repeats Pfam: PF02985. the function of this domain is not known.	20.10	20.10	20.10	20.10	20.00	19.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.46	0.72	-4.31	21	177	2009-01-15 18:05:59	2007-08-15 16:51:16	4	5	166	0	127	191	0	35.70	31	3.74	CHANGED	pslpclhcsLcaVtppDs.DslV+tpspssL-pL-sh	..........l.clh+lL+aVtsp-s..Dsll+tHAphsLEpL-s....	0	28	59	100
+10137	PF10305	Fmp27_SW		RNA pol II promoter Fmp27 protein domain	Wood V, Coggill PC	anon	Pfam-B_15444 (release 21.0)	Domain	Fmp27_SW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic SW and GKG sequence motifs.	25.00	25.00	26.00	27.30	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.00	0.72	-3.59	31	159	2009-01-15 18:05:59	2007-08-15 16:57:59	4	12	125	0	123	169	0	102.10	32	3.74	CHANGED	pAhp+LpcphSpSWlp+lcthcphpppphpchpphhaGtcp.htpshs.scsllshsppPsLhshlhc-lDlsls+PpFslcclscFlachGKGhP+spcYSlL	....Ahp+Lpcp.upSWhcRlcpthphppsphcchp..........ph.............hhGssc...sspshp....p..sc..pll..sh.sppPsLhshllp-lclslsKP.S.Fslcc..lPcFlHclGKGhPcDhcYoLL..	0	30	68	110
+10138	PF10306	FLILHELTA		Hypothetical protein FLILHELTA	Wood V, Coggill PC	anon	Pfam-B_18082 (release 21.0)	Family	This is a family of conserved proteins found in fungi. It contains a characteristic FL(I)LHE(L)TA sequence motif, where the bracketed residues are I, L or V. The function is not known.	25.00	25.00	32.00	30.70	24.20	21.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.02	0.72	-3.94	17	117	2009-01-15 18:05:59	2007-08-15 17:09:20	4	3	115	0	85	112	0	89.50	34	37.06	CHANGED	+lLpRl...P+Fh+.asp.hhsuPhoalsSFLILHElTAIlPLhulWahFap..........................hshhs.htlPsa.......hlscuh............chhcchhp+h.Gathhstpc	.................l.sRL...P+Fh+.Ysp.hhsuPl.oalsSFLILHElTAIlPLhuLahhFHh..........................................hsh...hs...hhlssh........hlscGs....................cpht+hhc+h..Gaht.t...ht.....................................	0	19	46	71
+10139	PF10307	DUF2410		Hypothetical protein (DUF2410)	Wood V, Coggill PC	anon	Pfam-B_19378 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known.There are two characteristic sequence motifs, GGWW and TGR.	22.10	22.10	26.30	22.30	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.30	0.71	-4.94	20	120	2009-09-10 23:56:53	2007-08-15 17:10:28	4	1	115	0	88	119	6	193.30	40	37.24	CHANGED	pSPLPNPpLWsusTIGhLpu.-sFuN.GGWWaDsclLuA..TG-GhthEcs+AWcGWWNEcIVcLlcLShcpKD..uLoVLLTGRuEssFucLIcRh....lcS+pLs...............FDhlCLKPp.sstspcasoThcFKpsFLc-Ll.pTYp.ps-EIRIYEDRl+HlKuFRcFFcphscp.........sRpslss-VIpVs-tspYLsPlsEsApVpchINsHNtsl	.............oPhPN...spLWsssslG.h.Lps.pshss.G.G..WWpDsphLuA.....ospuh.ch.c.cs+u.......hcu.............WWN-pIVpLl.chShppKD..........sLo........V...LLTGRsEssFsclIc+h..........lpS+tLp...............FDhlsLKPphs.....................tspcapoTMcFKQpFLccLl.pTYc..pucEI+lYEDRl+Hl+uFRcFFpphNpp...............sR.tsl.su-VIpVs-hsphL.sPlhEhApVpcMIspHNtth................................	0	21	45	73
+10141	PF10309	DUF2414		Protein of unknown function (DUF2414)	Wood V, Coggill PC	anon	Pfam-B_22455 (release 21.0)	Family	This is a family of proteins conserved from fungi to mammals. One mouse member is referred to as ELG protein but this is not a homologue of human ELG protein.  The function is not known.	28.90	28.90	28.90	29.00	28.50	28.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.98	0.72	-4.29	19	181	2009-01-15 18:05:59	2007-08-16 10:01:07	4	6	164	0	138	181	0	61.80	39	12.76	CHANGED	tplR.Esl+lpGVDshST-DlKsahstY............................hs.p.ss+IEWIDDoSsNllatopcsutpALhsl	...................plp.-plalpG..V..Dc....hoTpDlhsYhp-a.................................s.Ps.+IEWIDDoSsNlVatsptsAtcALhs...........	0	41	69	108
+10142	PF10310	DUF2413		Protein of unknown function (DUF2413)	Wood V, Coggill PC	anon	Pfam-B_20450 (release 21.0)	Family	This is a family of proteins conserved in fungi.  The function is not known.	23.90	23.90	24.20	25.30	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	444	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.80	0.70	-5.67	21	142	2009-01-15 18:05:59	2007-08-16 10:03:45	4	2	132	0	109	146	0	405.10	31	92.26	CHANGED	lL-hlDsLssspsssp...............stpspsss....sssps--DlLp.L--Ltppth.ppsp.....t................sp+pscsss........ssssssppppstscKsscospstpstshsssspsppp......tttsph.sshuShuuhWs..........WGshhusAp.h.psshcpAptsspcIpp...Ecsphhscplps.s.....stltsl.su...................cLt...hsTho....slhpslA.sl...socEhLpIHlsHDL..lsYsuL-.llhssFs+VMu.QVEGG....lhIthsp.sp......................t..tt..hp..ssss.+slshhpGhl.-GpKLs+ANhEshhccahpu+tsscpttcpupt..p......................-sssl+sSDIFluIQAlsh..........tustsp...t...s...h.hcsssssphsFslhL+D.spsIshpThSQuhPt+WhcWLDupt...............................tt.t-..-stslDPpEWVpEWlE-uLuLulGllAQcYVh+RMGl	....................ht.h-sLs.spsssp.................................tstsss...........ststs-pDlLs.L-p.Ltppp...p..st..........ts...........stppspsss....................ssstsp.p.ppt.s.tsp+sscssps.pttp...sspppsppt..........................tt.t.pshs.u....suuhW...............W.G.uh.huoAo.........tshcp..Apss...hpclpp.......Epspphscplpt.h.............s.lpsL.us..........................cLpt.s....hsThT....sllcslAPPI........uoHEhLpIHlsHDl..hsYsuL-sllassFs+VMu.QVEGGt...lslppspput.........................t..sts.hc..pssp.RslshhpGhs.-GpKLspAshEshspcahsscsshcptt.ppupp..s.......................csssl+pSDlFluIQsls.............ttssttp....t.ttsh....ht.pppspppls.FslhLpDshHsIsatThSQuhPt+WhcWL-uss...............................tt.tp..-ssslDP+EWVt..EWlE-sLsLulGllAQcYVs+RMGl.......................	0	30	62	93
+10143	PF10311	Ilm1		Increased loss of mitochondrial DNA protein 1	Wood V, Coggill PC	anon	Pfam-B_22448 (release 21.0)	Family	This is a family of proteins of approximately 200 residues that are conserved in fungi. Ilm1 is part of the peroxisome, a complex that is the sole site of beta-oxidation in Saccharomyces cerevisiae and known to be required for optimal growth in the presence of fatty acid. Ilm1 may participate in the control of the C16/C18 ratio since it interacts strongly with Mga2p, a transcription factor that controls expression of Ole1, the sole fatty acyl desaturase in S. cerevisiae responsible for conversion of the saturated fatty acids stearate (C18) and palmitate (C16) to oleate and palmitoleate, respectively [1].	25.00	25.00	25.80	25.00	23.40	24.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.04	0.71	-4.74	22	113	2009-01-15 18:05:59	2007-08-16 13:16:10	4	2	109	0	85	103	0	171.60	30	86.20	CHANGED	LSu+ollhu+shFLhsLAaahl+sPpslspsshVhlLGpuMpLsh..h.....hsp.pu.huhhulLhsh.AlsDLIsLht....sph....paapohsP.............................hRlhhaFhlssasYhspssh....................................................lpNplVFTYuFhEhhh.FhlassLR-ERpchhp+hs	..........lSopollhh+slFhhsLAhahhpsPpslsppshlhllupuMplPt..hp....hsp...sushuhhullhhhhulsDLlslhp....sph.....paapo.sP..........................................................................................lRhhlaFhlohhsYhhpssh...........................................................................l+NplVFsYsFhEhhh.FhlassLR-E+pp.hp+..h......................................	0	14	41	70
+10144	PF10312	Cactin_mid		Conserved mid region of cactin	Wood V, Coggill PC	anon	Pfam-B_20647 (release 21.0)	Family	This is the conserved middle region of a family of proteins referred to as cactins. The region contains two of three predicted coiled-coil domains. Most members of this family have a CactinC_cactus Pfam:PF09732 domain at the C-terminal end. Upstream of Mid_cactin in Drosophila members are a serine-rich region, some non-typical RD motifs and three predicted bipartite nuclear localisation signals, none of which are well-conserved. Cactin associates with IkappaB-cactus as one of the intracellular members of the Rel (NF-kappaB) pathway which is conserved in invertebrates and vertebrates. In mammals, this pathway controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo [1].	22.50	22.50	24.00	29.20	19.90	21.20	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.34	0.71	-5.04	22	283	2009-01-15 18:05:59	2007-08-16 13:39:26	4	9	220	0	208	282	5	178.40	35	31.47	CHANGED	p+tppstphccW.tcE-pFhLcQu+t+ucIRl+-sRuKPIDhLshtlchhp.................................pcsh-hph.h-P..slhpGL.shc-Lc-Ltp-Ichahp.LEpspt.ph-.aWpshhhlsccclpphcp.ptsts+uh..................ssVssDlpcllpsKohppLppLEtpIcpKlpSsps..lDhsYW.....EplL+pLpla..........KA+ApL+chap	...........................p.p-stphcpW.tpE-pFhL..cQAKh+ucIRl+-GRAKPIDhLuhhlph....................................p....................psshp.l-h...t-Ph..shhpGL.....ohp.....-hc-LhcDIcs.ahp...LEp.s...........p....Nh.............-.aWcshpslscDclp+hcp.htsps+uh...............................htsoVssDl..pplh..ps.KohppLpsL.ptpIctKlposps..........lDhsYW.....EpLLppLpsa...........hA+A+L+cha........................................................	0	77	118	171
+10145	PF10313	DUF2415		Uncharacterised protein domain (DUF2415)	Wood V, Coggill PC	anon	Pfam-B_25751 (release 21.0)	Family	This is a short, 30 residue domain, from a family of proteins conserved in fungi. The function is unknown. There is a characteristic DLL sequence motif.	20.10	20.10	20.10	20.30	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-7.96	0.72	-4.28	15	152	2012-10-05 17:30:43	2007-08-16 14:57:37	4	4	138	0	111	166	0	41.20	42	6.54	CHANGED	GAFRssKFS.tsshp...DLLllSEHpGRVHllDLRp....shps+QVIs	.GAlRshpFS..tsh........DLLsasEcpGRltlsDhRp....sFsp+Qll.........	0	29	64	97
+10147	PF10315	DUF2416		Protein of unknown function (DUF2416)	Wood V, Coggill PC	anon	Pfam-B_28778 (release 21.0)	Family	This is a family of conserved proteins found in fungi. The function is not known.	26.70	26.70	26.80	27.40	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.41	0.72	-3.80	12	63	2009-01-15 18:05:59	2007-08-16 16:18:41	4	1	62	\N	44	55	0	118.50	32	77.50	CHANGED	sthspoPhPuhhhuusL...lt+s.hssps.....................shhtPoptoshhFGuAphLGuahIYDGDlpNGuGFshAWSsLYLlVsG+sSlpulhhG+lhPLsLoslAluNAslYG++Fh	.................................................................s.....sP.st..h.s.....h..ps.h.tpps...........................shhtPoptoshhFusspulGuYhlaDGDhpNGuGFssAWSsLYLlVsG..+pShpul.h....hG+..hhPLsLoshuhsNuhlYGpcFh....................................	0	14	25	38
+10148	PF10316	7TM_GPCR_Srbc	Srbc; 	Serpentine type 7TM GPCR chemoreceptor Srbc 	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-11.88	0.70	-5.14	62	285	2012-10-03 04:04:29	2007-08-16 17:46:55	4	8	7	0	280	476	0	218.40	23	87.25	CHANGED	M.hhh.hhsshlullhuhhshhlNlalLhpIh.....ppKs-hhLFYaRFhlDlhauhslshahsahllh.........ph.schh...h+sllhalshsspslushRuhlslhIolERllAsahPIhY+saRpplPshhIhllhlshulh-phlLFsaCshsl.slPhsCsshtCulNpCahpYWthpcpllashhhhhSllLsh+La..lasp......tppsspplS+..As+lALlDuhhlhlFshlPshhsshh....hhshpshGPhsslhKhhGssIEulllh+lLh+cp	.................................................................................h.h..hshh.s.hshhhshh..hl.h............hh........pp.ph...Lh.h.h...+h....h.h.Dhh..h.u...............h..........h...h...hhhh.hh.............................h....s.p.h.....p...h...hh..h....h...shsh......hh.t..h..Rs..h.......l.sh..hI.sh-Rhh................AsahPlhapp...h.+..p.h..h....ss....h.h..l...h.h.h..h..h.h.hshh......-thlh..a.h....h..Cshth.phs.....s.CsshtChhsp..C..ah.pY..a.hh...c.l.h.hh..hh.....hhhoh.hlh..h+Lh......hhpt................t.tt...tspp........hp+...............ANp...lulhDshhhhhFshlPshhhs.h........................h.hp.hGPh.sh.+.hGhhlEuhlh...h.................................................................	0	91	105	280
+10149	PF10317	7TM_GPCR_Srd	Srd; 	Serpentine type 7TM GPCR chemoreceptor Srd	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.76	0.70	-5.43	59	467	2012-10-03 04:04:29	2007-08-16 17:47:12	4	12	7	0	462	1891	0	209.10	18	81.09	CHANGED	hplaaslhhlhulhhphhLlaLIlh+SP+tlcshphlLhspshsphhtshhshhsQ...........hRhl..sspholshlshG.C+ah.ushhCahsaphhhpshhtushslllohhaRYhhLpphp...pppphhhhhhlhYhhslhh.............lhhhhs.sst.tlpthpphhaPsY...shs.h.s.......lsGhhshpshsshhshhhhslsshhlslhhhhhR+KllphLpp..s.phSpso+shp+pLlpuLThQshlPhhhal.shhhahhsphshhph.hhpahlhshsslssllsPllolYFlsPYRptlhc	.............................................................................................................................................................................................................h....s....p.hhhhhhh...........p.s..ht........ht....h....hl.h...........s..h.......p.h.h.......h....s..h.h...............................R..l.............t.........h..h.h..h............G...s......p..h.......h........t................................h...s....h...............h...........................h................................................h.........s....h........h.......h.s.h..hh...+..h......h......h........................................t..........................h......h......h...........h......h..h....h...h................h....................................................hh..........h.h................................................h...........................................h.........p.h..........t.h..p......................................h..G..............................p....h...................t.............................................................h................h......h..........h....h....h..h..............h............h.........h......h...........h..h..h.....h.....p...t....t....h........h..t..h...l.........................h...s...t..ptt....tpph..........h...............h..............sLsh.Q...........s...h...l.......P..h..h.h.h.h..............hh..........a...h.......h.........................h........t....h.h....p...................h................p...hh.....h.................................h........s...hhsP...hh.hhh...l....sY+p.h...................................................................................	1	204	272	462
+10150	PF10318	7TM_GPCR_Srh	Srh; 	Serpentine type 7TM GPCR chemoreceptor Srh	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srh is part of the Str superfamily of chemoreceptors [2]. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.97	0.70	-5.61	186	1040	2012-10-03 04:04:29	2007-08-16 17:49:53	4	23	6	0	1028	2479	1	244.00	20	84.56	CHANGED	sSsphhshshHllshlslPlalaGhYsIlhKTPppMcsVKhsLlshHhasshhDlhlohlshPalhhPshuGaslGllphh.ulss.lQh....alhhshhs............hhssSllhlFENRa.h.lh.spt...hph+ph..Rhhahhhpahhs.hhhhhPshh.pl.....P.-Qppu+hhhhcph...P.C.....hspphhpt.sshallsh.-.t...hh.h..hshshhhhhhhhpllhFhhhhhhhlhpp.p....p.sh.SppThchQ+pFhhulhlQhslPhlllhlPhhhhhhshhhs..aas.QshsNls.hlhhuhHGlhSTlshlhlH+PYRchhhphhtt	...................................................................................................................................................................h....h..h...h.h....t.hPh....h...h.s....h..ah.l....h....h....p.o....s........hp.p.h+h.hh.........h.........p...h...h...s...h...h...h...-...............h....h.....h.......s...h...............h..h......h.........P..h................h..h..............h....P......h....h..u...h....h......s......h.....G..h....h.....t.............h......t.....h.......s...........h.......h................h...h...h...h...h....h...h..h................................h.h.s...hu....h.......h.....h....h.....F.....-....s..Rh....h......l.h..t..............h.h.phh........+h....h....h....h......h...........h...h...h.....s.....h....h......h.....h...h..s..h..h...h.......h........................s.......p...Q......p..........t....c................h..........h....p...h.h.......................P..s..............................s.............h...h...p............t...h...h.l....h..s....s.h.......................hh..h......hhh.h...h.h....h..h.h...h................h...h......p...h...h...h..h.......h.h...h......h...h.....h........h..h.t.t.................ph..S..t..pT..h....p.....h..Q.+..............p.h........hh.u..l...h...............hQ...h..............h......l............sh.h.....h.h.hh.Phh..h.........h.h....h....s........h....h...ht..................hhs....p.......h..............h...s....s........h.....h...h..........hhh....s...hH.Gh...h...u...o.....lhh.lhhppsYRphhhphh..h.......................................................	0	287	375	1028
+10151	PF10319	7TM_GPCR_Srj	Srj; 	Serpentine type 7TM GPCR chemoreceptor Srj	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily [2]. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	24.10	24.10	24.10	24.10	23.90	24.00	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.95	0.70	-5.31	35	202	2012-10-03 04:04:29	2007-08-16 17:50:14	4	9	6	0	199	1601	0	225.70	31	86.97	CHANGED	Ma.hsWhahalP+lFusLSFllNPlFlYLIhoEpps.phGNYRaLLlaFAlFNlhYSlssllVPlslaua+YsFhlalscGhFh...-poc..ls.ahlusRCuhlusSYAlLllHFlYRYLllassphhpchF.shhlhhShhhhlhahssWp.hlCahhhtus.Eh.RpYIRcsFpcpYssDShclshluuLYt-uSscshhRSWhuIhlhTslSshSlshallluhhIhpKLp..phssshSppTp+hQppLh+ALlVQTlIPIhlSF.PCllsWYuPlFslsLuphhNYhpllAlusFPFlDPlAIIhhLPsaRp+l	..............................................................................................................................................................................................h..ha.....hPh.h..h.h.h.u.h...hh....N....s....h.h....l.a.llhppp....p...hGpY+aLLh.......h..FuhFsh.h..h....Sh..hp......h.l....h.....P............h..................s..............h....h......s..........t.......s..h....................h..h...h......t.........G...................F.................t.....................h.t...h..h..h...s.........R................C.......s.h......lu.h...o.Y........u....l....L.........HF.la.....Ra...h.......s.............l..h........t..................s...p..h.h...t............t.....hh.............h..h..h.........h....h.............hh.......hh...h...h..a.h..h......hW..h...............h..s......h..h....h......h...s................s.........E.....h..+...........p....Y................l................p.................t............s..F...c........a.....s.......s...s......p.......h................s...h....l......h....s...h........a...............................t..........s......o.............t.........h..........h...........p.............o...........h.......h.....u..............h......h.....h....h.....o........h.....h.....u......................h.................s.........h..........h......h......h...h..................h.............u....h......h..............I...h...t....p.l.............t.......t........t..h.....S..t.p...o....p..hp...h...pLh...puL.................hl................Q...........o...............h..........I...............Phh....h...S.a...P...s....h...h.....s....a....a.........s.............h.......h....t....l..p..h..............................h...h...h...........t...s....h.sl...uhF.s.h......h.DPlA..lhhhlPshRpt.......................................................................................	0	50	68	199
+10152	PF10320	7TM_GPCR_Srsx	Srsx; 	Serpentine type 7TM GPCR chemoreceptor Srsx	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.69	0.70	-5.23	23	428	2012-10-03 04:04:29	2007-08-16 17:50:27	4	13	56	0	362	23544	3	174.00	18	62.30	CHANGED	hllGlhGNhlhIhlhh+cKpL+S+sshL.slpClucllplsGplhhsh.hhh.thphspspCFhhlshhlauhshQuslhLhlslDhLIhVpFPhhY+plpppt..YlhhthhhPllaSshlhhhGalttss-..hllhCssPhALsspuh...phashSslhlslhllllYhhhhhl.....h+tpspp..............pssshp+lhKSLploVslalhuWhhsplsstlhlthststphtthlphasuhhlhluhopsaaVhhhpSsEYRpsa+pha	...................................................................................................................................................................h..hu.l.h.G..N...hh.h.l.h.h..h........h...p.....p.....................p..L...+.......p.............h...................h....h.............l.s...h.h....s......h.h.c....h....h.....h..............h.......s........p........h.....................h.......h.........h.....h............h..........t....................h.................t.............h...............t..................t........t..........C...........h......h................h............h...........h.........h............h........h.........h..........h....h............p.......u......s.......l......h...l.......h.......h...u...h..D..p.........h..l......u....l.....h........P....h...............p.........Y....t.......t......h.p...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	107	136	265
+10153	PF10321	7TM_GPCR_Srt	Srt; 	Serpentine type 7TM GPCR chemoreceptor Srt	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srt is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.30	20.30	20.30	20.70	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.02	0.70	-5.67	39	386	2012-10-03 04:04:29	2007-08-16 17:51:09	4	7	7	0	383	347	0	231.10	25	87.42	CHANGED	p.LhYs.hpuhsL....YsCs.....tp.hsps.GhpRPhhGhhhlshGlll......hLYlPshhslh+pc.h.phssYKlMlhLulhDhhulhlsSlhTGhLshhGssFCsYPphIalsGuluhusWhuuChssllLslsRss-ls.phhhphlFctphhahllhh.llYuhYhhhFTpPllFsopahuWFFDPhl..G+ssc.....hYhNhscshNNhllsssTshLYhhhshhlhtKht.s...sotthpKsppQIhhQusllChFpssuAhIYshMpFhtss.hllllGplsWphupGsssllYLThN+TIRpull+hlh..+sh+hpp	............................................................................................................................hhGh..hh.Ghhh................hh.Yh.hhh.h.h.h.p.p..p...h.....s..sa.........pl.M.hhL...................uh...........hDhh.s.hhh....s......s.......l...h..sGh.hh.h.......G...h....s....aCph.P.......h..h.h.hh.................G...hs...h............s...................W.hhsshhs..hhLhhp....Rh.h.pl..................hh.h.......t....t...hhh....h.............h.hhh..h...hYh....h.....hh...h.......h.....h......s..........s........h....h...a..s....s...th.....sa.......hh....s..Phh..........t....t...p.......................Y...sh.p....hh.N.N..h....hh...shhh.hhh..Yhhhh......hhl.h.h..p.............tt.....p...................h................p..h...............p.................l........hh.Qsh..hl.....Chh.ph........h..s.u...h.l..Y...sh..h.p.h.h.....s...s......h..hl.h.h.u..p..h..hWph..........spu.ssshlYlhhNpsl.Rpthhphhh........h...............................................................	0	132	152	383
+10154	PF10322	7TM_GPCR_Sru	Sru; 	Serpentine type 7TM GPCR chemoreceptor Sru	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Sru is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	24.70	24.70	25.00	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.16	0.70	-5.32	38	299	2012-10-03 04:04:29	2007-08-16 17:51:26	4	5	5	0	293	318	0	226.40	25	90.73	CHANGED	oIaGsppYhsapasahs..hs.sllAhlPhlYllPThhllh+Ihhhahpshhpps.p..lNhplFhlIhlsQlhshhFFlsDalhlRLPsTGlhTSWCAs.pPNcaLpllhhhshYh.sYsshlaPhLlsllRLlllhhPppa.pclsp+Ih.chulPhlalaPhhhohhhlPAlGhC+QlthPa.FGulhlhapsshauhpN..shh.hlhsohhahhhsllhNhlLahKLcph.p....phsspppsptspKAElSLTlToluMllsalsNshhslsalh.....shhsYhlhlRPFGNDh-ssllPWlFYLTHPlF+++pp	......................................l.....a.paphp.......hs..hhhhhshhh...shhhhhp.hh.hhh.....t...t.......hp..lF..........h.h.............................h.........shh...........h..hh.-ahhhR.l.....P..o...u........h....h.Ts..aC.....u.....p.........ts..p......h.....l.....hhh.....hhh.hh...h...tY.s....hhs...hl...hshhRlhhhh...............stp....................p..............h...........th........lh..hh..hs.......hhhhhs.hh.hsh.hh..s.uhChph..Pa..aG.ul.hlh........................t.......h................h.s................h.h.............shh..hh..hhhh..hhhhhhshhhhhKltphp....................t...pp..p.+uEho....lohThh....hlhsh..l.hs.....hhhh.....h..hh...................shh...a..h....h..hhRshh.DhphhhhshhFYhTHPhF+pp..h..............................................................	0	41	58	293
+10155	PF10323	7TM_GPCR_Srv	Srv; 	Serpentine type 7TM GPCR chemoreceptor Srv	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srv is a member of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.64	0.70	-5.28	25	258	2012-10-03 04:04:29	2007-08-16 17:51:59	4	9	8	0	256	5739	1	205.70	17	78.89	CHANGED	aashsllolPlYlhllhsLlchRptshs.apTsFYplLlp+sIADlhshlsahhstsh.phshhcsFYaphQpaY.AuhhashhYhslhIRssGlshLohpRahsIshPp.phsphhpssphapllhlaWlsshllull...sLtssshtYcshcs..hshls-cshlppsohhAhlhlslsClhhllsYshLahhlR................ppops........ho+uhpREh+LshpVhlllhA.hshhsaahhpshhu.....pstsss..lFYhRhlYPlssGllSaINPaslLlhN+-lp+plhpplps	.....................................................................................................h.....h...........h....................hh...............................a.a....l...h...h..t.hhDl.h.............h.....h..........h..h...............................h..................h..........h......h...h.................t............h.....h.......s...............t.....h...........h.............h....h...h.......h.h...h..p.h.....h.....s....h...........h.....l.....s...h...p.....Rh..s.....lh..h.......P...........................h.....p............................h.h....p.t...........................h.....h.....h.....h.....h....h........a......h.............s....h......h......h....s....h................h.h..h.......s........p...............a.......tt.................h..h....h.....h............s.....................h........h...............t..................h.........................h.......h.......s........h........h......h....................h.........s.......h........h..........................h...............h.....h....h.h....h....h...h.p..........................................................................t..............p..t........t.p..E..h....p...L....h...h..........s.........h.....h....h.h............h.......h.........h......h........h......h......h.....h...h............h................................................t.......h...h.....h......h...........h....a....s....h......h.......s....h......h........s....h....h....s....shh....lh..hhsp.htt.hh.....h......................................................................................................................................................	0	83	107	256
+10156	PF10324	7TM_GPCR_Srw	Srw; 	Serpentine type 7TM GPCR chemoreceptor Srw	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2]. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz [3].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.16	0.70	-5.31	90	944	2012-10-03 04:04:29	2007-08-16 17:52:27	4	31	52	0	866	4349	0	230.20	17	73.85	CHANGED	thph...hluhhulllNlhHlhlLTRKuMRssSlNllMlGIulsDlhshhhslhphh..hhhth............cC.h.....sss.oYhhhh..hphhhtslpchs+RsSsWLulhhAllRhLll+.Phss+hppLupsphuhhllhhlhhhshshohhha.hphp.lh............p.t.hh...........C........t..h...t...sthtYhhhhschh...pthhhp.hhhhhsulh.cllPsllhPIlTlhLlh-L+Ksp+p+pphp....ppt............cscpoT+LVlhhTIsFhluEhPhGl.shhl.............phh...hhpss......sl....hhlhpphshhhshlhslNussHhlIChhMSSQYRpTs+plhttp	..........................................................................................................................................................................hh.hhshhhN.h.h.p.h.h.l..L...p.....t..h.t..t..s.h......hhhsl.shsDh.h.hh..h......h........................................................h.........h.h...h.....h.....h.................h....hhpth...u.....hals.lhh......Ah..h...Rhh....l...t...........p..........h........h..t......s.h.hh....h..h..hhh..h..h..........h.....h.........h.....h...ht...h............................................................................s..................................................a............................................................................h....h.....h...h.s..h..............h.................p...............h..........l..s....s...h...h..h...hhs.h..h.....L..h.....h.....t.........l.....hph......p........p......t...p..tth.....................t................t...................ptppoo.....h.h.l...h.h...h..hh...ahl....s.ph..P....uh..h.hh.................thh.......................................................h...h.........h..........h...h.........h.h..h.hss......p.hhlhh.hSppa.Rp.hh.hh...h.....................................................................................................	0	227	294	847
+10157	PF10325	7TM_GPCR_Srz	Srz; 	Serpentine type 7TM GPCR chemoreceptor Srz	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srz is a solo families amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2]. The genes encoding Srz appear to be under strong adaptive evolutionary pressure [3].	21.30	21.30	21.30	21.50	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.98	0.70	-5.27	62	372	2012-10-03 04:04:29	2007-08-16 17:52:46	4	15	4	0	367	410	1	207.80	21	75.85	CHANGED	hhhhhhhhhhlhhhllhPFYlY...VhKlNRc+D+phhlaP.lssHFYch...l+hsYhlhhhhlhh..hhhhhhhtt...................hhhhlhhhhhhhhhhh....LhllsplFalLlhLLAlp+FllYFF.PptE+hlhhspphh.+hlhhlYlhhllK.-lhhhhhhhhph.t..................phhthhahhh........................hhhhs....lllhlSulLYIPIhISlR.Khup.Lt.SsQpspPppYIaaQolhVhlhKhlhl.hhlhhhh...hsthhhh..........hhhhhDhlooPLIIQlSYLsCN+	................................................................h................h.hahh...h...s..pcp..t.............................ha...lhp.hhath...hhh.hhhh.hhhhh...hhhh.hhh...................................h.hhh..h..hh....h.hhh...hhh........hhh....hs..psh..ph.l.l.llAl...p.....+hhlaF...h..P.p..cphh.h.pp....h...h.h.lh..hhYhhhhhh.p..hhhhh...h..h.h.h..........................................h..h.h....hh................................hh.hhp..hhhhhoshlYlP....l..h..h..pl.p.+.ht.....h..s.t.....sps.ppalhhQhhhl......h..hhKhh....h.hh..hh................h.....................hh.hhDhhh..hPhllQhoYlhCN..........................................................	0	76	76	367
+10158	PF10326	7TM_GPCR_Str	Str; 	Serpentine type 7TM GPCR chemoreceptor Str	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split [2].  Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [3].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-11.93	0.70	-5.30	178	1469	2012-10-03 04:04:29	2007-08-16 17:54:00	4	34	10	0	1456	2149	6	223.40	21	82.72	CHANGED	pphhphhuhhhuhhhNhlLlaLllt+ut+phGsYKaLMlhFolhulhaohl-hlspP...............hhHsass..ualhh.h..p.hth...spthtthhl...............s....las...uhauhsluhlulpFlYRYhulppsp.t..l.chFpGhtlhhWhhhslhhGhhWshshahhhtssp......sscal................+.pph..hcpYs.lshsclsahuhhaa............spsG..p....lphpshhshhhhshlhshsahlllahGh+hahph.pcltph....Spps+cLQpQLFpuLllQollPhlhhalPsshlhhh....Phhs....l...ph.shhushlshslulYPslDslshhhllpcYRpslh	.............................................................................................................................................................................................h........h..s.......s.h.hh...hh..h..h...........h....u......Y.+....h....hh....h...h....sh....h......t......h.........h......a......s......h..h......p..h..h..h...P......................................................h.h..............t....hhhh........t......................h........h..h..........................................hh.s.....s.....a.s.........h.....h..h...........s...h..p....Fh......a.......R.a...h.sl...............t.......................................h...t.h.h..p.................h..h..h..h.................h.h......h....s........h.h...h..h..........a.....h....h.............h....h..h..h..h.h..........s...........p..t....hh........................................p.....h......t.....h...t.....h...p.........p...p....h......h.h.s........hha......................t.p.s...................h..p.h...........s.h..h.h..h.h...............h.................h.h...h...............................h...............p................h......h...h....h.....h.hu....h....t...........h.a...h.th....pph.t...........S...pplp.p..Q..................ha...h.s.....Ll..............h..............Q..............s.h..h............Ph.h....h...hahPh...h..h.h.h.h.h....P.h.h.t....................h..ph....t...h....s.t.h.h.....h.......h.h.s.ha.Ps.h.Dsl.hhhhl.ppaRph..h.............................................................	0	456	563	1456
+10159	PF10327	7TM_GPCR_Sri	Serpentine_Sri; 	Serpentine type 7TM GPCR chemoreceptor Sri	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.80	0.70	-5.46	54	363	2012-10-03 04:04:29	2007-08-16 17:54:30	4	17	7	0	359	1625	0	222.70	22	82.08	CHANGED	hslDFssPhaLlhaaalIGslSlllNhhsIYLllFcSsKlcsF+YaLLhFQlsshloDlplohLhQPhsLaPlhuGashG..hhsph...htlooHhthshhshlhshQltuLhhCFlpKHQuIuplh..ppp..hsp....hhhhhhhhhshhaPhhsshshhhsslsc-pphcalcpsaPphhspFtsLssFslYphs...ahhhhhlhshhsshhshslhshhshchhphLppl+pplSspsYp+H+sAlpSLlsQhhsoslhh.lPshhhhhllhhthstuQ.....hIsphhhslhssHSslNslVllhosPsYR+hl	......................................................................................................................................................................h.h..h.h.....t..................t.....a.p.............h.h.h.......h.........h...Q.....h.........s.......h.h...s-....h.......h.s.....h.....l.........hp..s...h.............l.....a........P.........h...h.......u...G...a...s..h....G...hh.s.ph............................h.............s....a....h........h........s................h...h................h.......h......h...h...h...........h...p.............h.........t....s..............l.hh..C......F........h....h....K.Hp..s..l..s...t...h...............p.h.h...h...h...s...p.................h..h...h.h...h..h....h....h.....h.....h....h....h..h....s......h...h....h....h....h...h....h..............................t........h.............s....p...p.............p...p...h....t..h...................l......p................p......p............a.....P..............p........h....h............................h.......p.........h........t....h...........l........a......s...............h.h...h...h...h.......h...h.........h...h....h...h...h....h..h...h...h.....h...h.h..h...h..h.h.h...p..h...h............h...h.....t.........h...p.........p....h.....S......t...s..h....ph...a.pt.s.l........h..............o.....Lh..h..................Q................h....h.................h..s.....hhh..........hP...h..hh..h...h....h..h..hh.......h...........p.....................h.s.......h.h..h.hhs..p.u..h.s.h.hhh..s.aRth.................................................................................................................	0	104	134	359
+10160	PF10328	7TM_GPCR_Srx	Serpentine_Srx; 	Serpentine type 7TM GPCR chemoreceptor Srx	Thomas JH, Robertson H, Bateman A	anon	Thomas JH, Robertson H	Family	Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type [1]. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf' [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.91	0.70	-5.29	80	586	2012-10-03 04:04:29	2007-08-16 17:54:54	4	18	10	0	579	7241	0	219.70	18	82.16	CHANGED	hhluhhGhlhNhhlhhthh+.h.shpsSFshlstspuluNslhsh.sFLha.hsPhslhshph..h.p..pohhsthhshhsYth.ushsplhlolNRFhAlahPhhYpplashphTph.......hlhhhahh.........uhhhhhlhhhhhsCthhas.phhsat..spt..hC.shh.sh.h.....hhhhhslshhsshlsllThhKlhthppph...thspt..pspp+pp+..phphhhQoshQshlahl-hlshahl.sph............hss.phhpFlssohsWhhlHshDGhlhlhFN..pclpphhhpphpt	.......................................................................................shhG.hh.h...N...h...h....h....h......h......h.....h.....p.......................p...s...u.....F..........h..l......s..h........p.sh.s.s....h....h....h............h.....h......h....h......h......h......h.h.....P..h...........h......h...........t........................h..........................s......h.......h.......t.........h.....h...h.......h....h...h.......a.................h.....s...................h........p....h....h....h...uhNRh.hslh.h.s.....h....h....h..p......p...h..h...s.h.............T...h...h................h.h.h.h..h..h..hh....................................sh........h...........h...h...h............h.........h....................................t..............C......h.....h....h........a....s.........p......h......h..........a..........................t.....................C.......s.......h............h.........h.................h..h..h......h..h.....h...........h...h........h.............h......h..h......s.....h...h...s...h....h................+....l.h...h.......phth..........................ttt......t.t..p...p...pp......p+..............ph...t...h.h..........h...Q.............s.....h....h........Q.s..h........h..h........h....h......p...h...h.........h.h..h..h......h......................pp....h...h......F.....h.....h.s..s...h.....h.....hh...p..s..h..-.G....h.lh.hh.p...ph.........t...............................................................................................................................................................	0	177	228	579
+10161	PF10329	DUF2417		Region of unknown function (DUF2417)	Wood V, Coggill PC	anon	Pfam-B_22799 (release 21.0)	Family	This is a region of a family of proteins conserved in fungi some of whose members also have the Abhydrolase_1, Pfam:PF00561, domain in their sequence. The function of this region is not known.	25.00	25.00	32.30	32.10	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.62	0.70	-4.95	21	122	2009-12-10 16:57:14	2007-08-20 13:09:06	4	4	112	0	92	118	0	228.20	36	43.81	CHANGED	sE+p.LLs.................................ptsalsPDDPt....VSPaNLap.....lRhlRslsslhlhlohlhahhhLlS.Fl....u.PuhpsRGsuFhshshshlslhh.llsLhF..FulPSphtplhuhllusLLllDhlllluVstlRhc.GWlGluollWAslhulhssltDhhV.............................thGKpc-EERL.....TGR.......EoR+oLpEWlslhlcolhhlllhllshLhTlTLhLpAhDus..................hts.GphahVDssp.apVHLsCh	..........................................E+p.LLspp.............................................tspsaLsPDDPs.......VSPYNLap.....lRhhRhlsslhlhlshlWalhlLlS.Fh....o.Puh..psRGuuFhshshshlolhs.hhsLlF....FulPSp..plhshsluslLhlshhlhluV.phRhcEGaVGlsoslWAslhulaslhtshhV........................................thGKpcEEcRL...............TGR............EoR+oLpEWhslhlps.lhhhlhhllshLhohTllL+uhDup..................hss.GphaaVDss+.YplHltCh...............................	0	18	44	76
+10162	PF10330	Stb3		Putative Sin3 binding protein	Wood V, Coggill PC	anon	Pfam-B_24989 (release 21.0)	Family	This is a family of the conserved N-terminal end of a group of proteins conserved in fungi. It is likely to be a Sin3 binding protein. Sin3p does not bind DNA directly even though the yeast SIN3 gene functions as a transcriptional repressor. Sin3p is part of a large multiprotein complex [2]. Stb3 appears to bind directly to ribosomal RNA Processing Elements (RRPE) although there are no obvious domains which would accord with this, implying that Stb3 may be a novel RNA-binding protein [1].	25.00	25.00	25.60	42.90	22.60	17.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.10	0.72	-4.30	17	120	2009-01-15 18:05:59	2007-08-20 13:31:59	4	1	112	0	92	118	0	95.00	50	22.14	CHANGED	lTPphLup.....lLLp+GPLAIRHlhsaLopplPuFuclssuKtRRLlhuALE.......uGs.cssVlFEKlGWGpWs.....A+chspPtphspphptos.u	.........ITPuhLAph+Ls-ILLp+GPLAIRHIhuaLTssVPGFutlssuKtRRLlluALE...........uGsh-ssVlFEKVGWGpWs.....A++tspssphspt......s..................	0	13	44	77
+10164	PF10332	DUF2418		Protein of unknown function (DUF2418)	Wood V, Coggill PC	anon	Pfam-B_29723 (release 21.0)	Family	This is a conserved 100 residue central region of a family of proteins found in fungi. It carries a characteristic EYD sequence motif. The function is not known.	19.00	19.00	19.50	19.20	18.80	17.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.25	0.72	-3.70	19	132	2009-01-15 18:05:59	2007-08-20 15:52:43	4	2	128	0	103	132	0	101.10	36	22.07	CHANGED	pcclapLpVW-Ps.aslplFshFSPsplllhhhh..........sssshpshhhhllhoh.hhhlhp.pFpphlcDcpllppEshpEYspKaVcP+hpshppDsslss	...............p.c-VWpLslWDPtsh..slpLFshFSPsHlllhhhhhs.......................Ssshhpslhlt.sllohph...hhLhs.pFsQphKDptllppEVhpEY-sKaV+PRhpshh+DVusp.h............	1	28	58	89
+10165	PF10333	Pga1		GPI-Mannosyltransferase II co-activator	Wood V, Coggill PC	anon	Pfam-B_50403 (release 21.0)	Family	Pga1 is found only in yeasts and not in mammals. It localises in the ER as a glycosylated integral membrane protein. It binds to the GPI-mannosyltransferase II subunit of the GPI and it is responsible for the second mannose addition to GPI precursors. The GPI-anchoring complex is a glycolipid that functions as a membrane anchor for many cell-surface proteins [1].	20.00	20.00	20.30	20.30	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.06	0.71	-4.63	5	47	2009-01-15 18:05:59	2007-08-20 17:40:11	4	1	43	0	29	37	0	180.10	31	85.69	CHANGED	lsllaLCslVlANTETapl+VP+-FPsposttpspuoY...sshlshIsL+NlshspIs....oTclssssssYV.ELscLp+sETYQVKICWTAIDPISIsDlsallIPHuTtFpGTlS-cA......RlhVpFcVpuDSYPlLsDsphVPVsVSllslKLGIPVDLYslLlYlllVl..uISlllshcPapLLc	.............h..lhhhls.hlhANTEoh......Lh+VPp..sF..s......lp...ps.....tssssht.................h.sshls...h.o..lssps..h.ophh........sssh.....ph.c.s..Tpal.cLss.....L.....p.....ps-s.Yp......IKlCWsAhcPhshpslpphhhs+.sthttohsD.h............clh..lpa..p....hh..u-..SY........s..............ppp.shlslpls...l.ss...hL.....s...IPl-lYshllhhl.ls...hhhlh................................	1	3	13	25
+10166	PF10334	DUF2421		Protein of unknown function (DUF2421)	Wood V, Coggill PC	anon	Pfam-B_39020 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.17	0.70	-4.74	21	168	2012-10-02 19:04:43	2007-08-21 09:54:30	4	10	89	0	134	204	0	205.10	18	19.91	CHANGED	PR.PsSu++tlcpsLupslcsluslastlhsahsp............sschclhuc............h.thhlpltt+LsuLpthlshLpaEhohpGhWPpppYtclpsLhp-lspLhspLhhlhspL..Pttah.cLhcpsGhhcpphhu-lhAVltMsppAL+oGssLPclhPssLsh+ph-hhcpphtstc...............................t.lshchlcspshppasVulshhhplhs+l...D-llllVKullGEta	................................................................................P.P.oupphlRpslupslhtlushYs.hlh.sthtt.............................................t.t..h...p...................................h..phh..h..p..h..ttpL.t.slpshlthhpaE.sl.tGpFP..p..p..p..Ypplhphhp.pllphl..stl.h..h...sh...p....pl...............s.............p........p....h...p..pt.l.hph.hth.........h.cp.........phh.up.lh.slhthlusulcstpsLPthhs...............h......p..h.h...h..t...........................................................h.p..thh.p.th...................hh..th...cphh..hp.hhG......................................................................................................................................	0	47	81	117
+10167	PF10335	DUF294_C		Putative nucleotidyltransferase substrate binding domain	Bateman A	anon	Bateman A	Domain	This domain is found associated with presumed nucleotidyltransferase domains and seems to be distantly related to other helical substrate binding domains.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.37	0.71	-4.55	86	1001	2012-10-01 22:14:54	2007-08-21 11:02:28	4	14	661	0	348	952	154	140.10	29	24.93	CHANGED	shaLtt.hApsulphpsP.LGhapplhsppps..ttttlDLK+tGlhPlVcssRlhALpp.................u.lpsssTh-RlctLtptGhlstchspsltcAachlhplRLppQlpph.psGp.....ssshlssspLsphERptL+-uh+hlcchQphlphca	...................................................................t.halsthucsAlphpsP..LG.hFpshhhc+..sG...ttttlDlK..ct..GlhPllchsRlhALtt.................G.hp.s...ss.Th-Rlcslh..c.t.s......lLspppupsLp-AachlhplRlcpQhtph..ppspt..........ssN.tlssc.pLsphE.Rc.tL+-uhpllpphQphlth+a....................................	1	100	229	306
+10168	PF10336	DUF2420		Protein of unknown function (DUF2420)	Wood V, Coggill PC	anon	Pfam-B_32350 (release 21.0)	Family	This is a family of proteins conserved in fungi.  The function is not known.	21.00	21.00	22.00	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.23	0.71	-4.49	13	112	2009-01-15 18:05:59	2007-08-21 11:16:24	4	1	110	0	84	116	0	106.70	27	16.46	CHANGED	shlhcssulhctols-hauslRp.h-pt.GphhssscELlLshspL-.LslsEDNlYsccIohsDllslFchLpppohpptc.slPcsLshpLo.spPRFlo+YNsLs-hscsstu	....................h..hcstulhppslsclhtuhRphlt...sphh.sssc....ELllplcsLs.LplsE..Ds...s..asp..ploLppllplaptLpppst.st....PpsLhlpLo.opPpFhscastLsphspps..s..................	0	20	44	70
+10169	PF10337	DUF2422		Protein of unknown function (DUF2422)	Wood V, Coggill PC	anon	Pfam-B_42729 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known. This family is the C-terminal half of some member proteins which contain the DUF2421 Pfam:PF10334 domain at their N-terminus.	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	459	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.39	0.70	-5.70	27	237	2012-10-02 19:04:43	2007-08-21 13:24:18	4	14	109	0	197	260	1	360.00	14	36.09	CHANGED	hhhssWhh.pL.Dhtoh+lhhRshhsshhshhlhhhssshphhGsuuYLhslluhls.s.thshshhlhhhlhhhlulsluaAhu.llshhhuscsRtp..........................ssssshsssspsthhpu.hhsupsouVhslhLhht..lahhshhRs+....aphshIhs.IhsslhhsaushhPsh.tshslsttLlcPhulululshssulllFPhooshhhhpph.tuhlshL+sslphppsahpohcsss..h.................................pplcpshtplpshhstlcsshshhhhEhuhG+hsssDlpslhphlRplhhsssGLshhhphhpch........................................................sclspapp.pshphhc.......s.tc............phshpphsclh..ptlcc.hsshlcsscpuLppl....sphLphssph+...t.hh...hppptptp.phttph......tshtpphcpphpsFtsscphtLhthtp	..................................h.............s...hhhhh.........+s.ls.hlshhhh..s.shph...h.s.p.hsahhslhshhs.s.hh.hhhhl.hhhh.hhuhhhuhuhs.hlshhhu.tsh.t......................................................hpst..slhhlhhhh...hahhshhRsh.....h.hshl.hh....lhhs..l.hphushhsh....shph.sp.hhhshhhuhuluhssslhlaP...osp.thhhpth...hthlt..lpthl.ph.pht..hh.ts.t.....pt............................................................................ptl.ptth.ttltshhsthpsshthh.h-huhup..hsspDlptlh.p.h.h+plhh.h.uh..hhphh..h..............................................................................................................................................................................t.ht......hp...t......................................t.h.p.hh....htp..t.h.t.....ht.slthh.......ht.....t..........................................................................t...............................................................................................................................	1	55	107	167
+10170	PF10338	DUF2423		Protein of unknown function (DUF2423)	Wood V, Coggill PC	anon	Pfam-B_46946 (release 21.0)	Family	This is a family of proteins conserved in fungi. The function is not known.	27.60	27.60	27.60	27.60	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.05	0.72	-3.98	20	136	2009-01-15 18:05:59	2007-08-21 13:32:42	4	4	128	0	108	129	0	44.80	43	29.28	CHANGED	MAKSLRSpo+hps+ohKR...csVFthss-ARspRlusKLccphtppc	MAKSlRups++ps+uhhR...psVFusstcARscRLSsKLp-hhtp.p......	0	33	61	95
+10171	PF10339	Vel1p		Yeast-specific zinc responsive	Wood V, Coggill PC	anon	Pfam-B_50673 (release 21.0)	Family	This is a small family of proteins from Saccharomyces and related species. The function is not known but member proteins are highly induced in zinc-depleted conditions [1,2] and have increased expression in NAP1-deletion mutants [1]. The S. cerevisiae genes are named VEL by association with Velum formation in the wine making process http://www.ajevonline.org/content/48/1/55.abstract	23.00	23.00	289.00	288.80	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.64	0.71	-11.48	0.71	-5.16	4	33	2009-01-15 18:05:59	2007-08-21 13:58:00	4	1	18	0	12	21	0	189.20	81	98.25	CHANGED	llshF.shIsl..ssAlRFDLTNlTCptL+GPHCGTYLL+VsGpNuTaLGQphFVGhDALTpstsDhatRhLcpEsRhIPRLTTlAp.N-TsNFpPhhFTTshsTCNPQSIEsAhlPFlNTVTsEIpYDSWA.Tu.NAShITGLANQLhNuosYGVQVAoChPGFssslhsoPTVNlFNs--slPSWCpAIElcAVCPhDsGFs	......hhhh.hhls...ssAhRFDLTNlTCptL+GPHCGTYlMEVVGQNGTFLGQSTFlGADVLTESAGDAWARYLGQETRFLPKLTTIAS.N-TKNFSPLIFTTNI.TCNPQSIGDAMVPFANTVTGEIEYNSWADTADNASFITGLANQLFNSTpYGVQVASCYPsFASVILSTPTVNIFup--TLPDYCTAIQLKAVCPP-AGFs...	0	4	4	8
+10172	PF10340	DUF2424		Protein of unknown function (DUF2424)	Wood V, Coggill PC	anon	Pfam-B_51256 (release 21.0)	Family	This is a family of proteins conserved in yeasts. The function is not known.	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.39	0.70	-5.82	5	116	2012-10-03 11:45:05	2007-08-21 14:05:56	4	3	60	0	80	2905	696	294.20	23	74.90	CHANGED	LpFLs+llslLPItll.....hcSIsllshs+R+LslDhLoRlFhRpShhLhDctICpYVLNPla-.lu.sLaK.ph.s.o..chslPp-Dpps.psslFsc+hlNpshhpSphaWhtph.PcsFcPclD.PlLLYaHGGGaALpLsPsoLlFLsNltKhFP.cM....AILlsDYoVTAspscopcYPhQlLpslslY-YlspohGCKNVslMGDSAGGNhVLslLLY...L+KpNK.llPKKAIAISPWlNsThhsEpE+saM+ts-clDulChKuLshFG+hYlsN...-supshpo-sFlNIE+Na-h-sWscI..lcKCcLLITYGDDElLphQIKlalcKIo-hptt.pa.pscNVLl-c...QGsHIG......P.ILsassNlD+WoKhsSlscILsF	.......................................................................................................................hh..............................................................................................................................................................................p............h......Wh..h.p............t......ps..p...s.D....P...l...l.lYhH....G....G.....G.Y....h....l........p.........h....h....s....s....p....l.....p......h....L....h.....s......h....h....p.....h..l....s.....ch.............................u.I......L..l.....l.......DY.......s...L.......s......s............................p.........u...t...h........a........P......t...Q...l....h....p....h....l.....s......s........Y........p.............p......L........l......................s.........p.......G.........s............p.........N........l.....h......L.....h...GD.SAG....G..NL...s..l.s...h...l...pa........................L..p......p.........p........p...................s...........h...........P..............+........p.........s...l........LI......S.PW..l...ph...s.................p..pt...t.....t..p.....hp...t..s...p...ph.D..h.l.....s...h.....p...t..h....p..........h...t..c...hahss..............t..t..t...h.........s..h.ss.h.....tt............p...p...Wpcl.......hp....p...t......s...shlhh.G-cEhh+-plhpas.phh.............................................................................h.h.............................................................................................................................	0	15	37	72
+10173	PF10341	TPP1	Est3;	Shelterin complex subunit, TPP1/ACD	Wood V, Finn RD	anon	Manual	Family	TPP1 is a component of the telomerase holoenzyme, involved in telomere replication.  It has been demonstrated that TPP1 dimerises and binds to DNA and RNA. Furthermore, TPP1 stimulates the dissociation of RNA/DNA hetero-duplexes [1,2]. Yeast telomerase protein TPP1 (Est3 in yeast) is a novel type of GTPase [3]. The key residues in Swiss:Q03096 are an Asp at residue 86 and the Arg at residue 110.  The Asp is totally conserved in the family, whereas the Arg is not so well conserved. The N-terminal of TPP1 is likely to be the binding surface for TINF2, whereas the C-terminus probably binds to POT1, thereby tethering POT1 to the shelterin complex [4].  The complex bound to telomeric DNA increases the activity and processivity of the human telomerase core enzyme, thus helping to maintain the length of the telomeres [5,6]. This domain is conserved from fungi to mammals, hence family Telomere_Pot1 has been merged into the family [7]. The human shelterin complex includes six proteins: telomere repeat binding factor 1 (TRF1), TRF2, repressor/activator protein 1 (RAP1), TRF1-interacting nuclear protein 2 (TIN2), TIN2-interacting protein 1 (TPP1) and protection of telomeres 1 (POT1) [8].	21.90	21.90	21.90	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.51	0.72	-4.06	51	102	2012-09-26 10:57:07	2007-08-21 14:13:12	4	1	93	2	67	107	0	118.70	21	19.44	CHANGED	sWIpphlhsthptp..................................hhtps.sspll+llca................sssssshtul............................lSDusapIhulFo.pculppac..pcpc....pchp.........tsspssllhlpchplpht...sppthssca....................................hLp.....l	....................................sWIppllhsshp....................................hhssstsspllcllph..................sssssshtsl............................lSDusapIpslho.cculpphc.....hcpc.....phhh.........psspspllhlpchplhhp...sptthssca.......................hL.................................	0	14	27	47
+10174	PF10342	GPI-anchored	Drmip_Hesp; Drmip_MAPK;	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family	Wood V, Coggill PC	anon	Pfam-B_42324 (release 21.0)	Family	Some members of this family appear to be serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. In A. fumigatus these proteins play a role in fungal cell wall organisation. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organisms as it interacts with MAPK. The family is also found in archaea and bacteria.	26.00	26.00	26.00	26.00	25.70	25.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.48	0.72	-3.51	101	635	2012-10-04 12:14:07	2007-08-21 14:16:40	4	18	172	0	476	646	9	93.20	21	35.69	CHANGED	os.P.shs.pslssG...p..hTlsWsss......sss.......ssholhLhpGss...s.hssh..tsl..ussls.su.....uo.aoass....ss..s..lssss....s..Ytlplh.s.ssss.......hsYSspFsl	..................tP.stssshssG....ps.hslpWpsst.......sss..........ssh.sl.hLh...sGss........tp..hs.sh.....tsl...us...s..ls....ss............uo..as.hss..............ss...s....lssss......s...Y....tlplh..s..ssss.......hsaSspFsl..........................	0	169	295	400
+10175	PF10343	DUF2419		Protein of unknown function (DUF2419)	Wood V, Coggill PC	anon	Pfam-B_35257 (release 21.0)	Family	This is a family of conserved proteins found from plants to humans. The function is not known. A few members are annotated as being cobyrinic acid a,c-diamide synthetase but this could not be confirmed.	19.90	19.90	20.00	19.90	19.40	19.80	hmmbuild  -o /dev/null HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.78	0.70	-5.15	21	302	2009-01-15 18:05:59	2007-08-21 14:49:58	4	5	236	0	233	297	138	246.10	34	73.73	CHANGED	HELHPps...cD......cpTVsalFlhDhLNFuFWo-ps.........tpaslpY+G+taTGYaSLsAAlpRAL-cGIsITsPpFa...pchT.chL+c.lF+Ssot..cclPLLp........ERlcsL+EuG+VLhcca-GSahNhlpsu.spSAssLlpLls-sFPsFRDcssacG+........+..VphYKRAQILVADLWusFpGcu....h.GcFcDIDpITMFADYRlPQhLppLGsLtYospL.pcl+ppchIssGuphElElRusSIasVEhlRctlp+pcsc.t........................................................................lNAILIDaaLWDht+chptcht.........plPaHRT.......RSIaY	...............................................................................................................p........ts.......ttsspalFhhDhLNF.s..FWsptt..............h.ap.................p.hpGYhsLsAulp+Alc..p.shsl.hssphh......tpho.p.lpp.lhcs......s.t......h..Plhp......................ERhph.LpE...sGplL.......h.c.c.......a....tGs....hhshl.p.p......u......p...t....S...At......tLlpllsppFP.s......FRDtsh...a..c..G....+...............p...VthaKRAQILVADlWusa.p....G.p..u...................h..G...p..F.....p.........D.Is.p....l..T....MFAD.......YRlPQhLhphGsLpY.S.spL.ptl.....cp....t.p......l.sGsp.E..................l................ElR.u.......sSlhslEhlpct....l.........p..h..p.................................................................................................l.s.ul...hlDaaLasht+phtt..p........................lPaH+spsIaY..................................................................................................	0	93	135	198
+10176	PF10344	Fmp27	DUF2425; 	Mitochondrial protein from FMP27	Wood V, Coggill P	anon	Pfam-B_54917 (release 21.0)	Domain	This family contains mitochondrial FMP27 proteins which in yeasts together with SEN1 are long genes that exist in a looped conformation, effectively bringing together their promoter and terminator regions. Pol-II is located at both ends of FMP27 when this gene is transcribed from a GAL1 promoter under induced and non-induced conditions [1]. The exact function of the Fmp27 protein is not certain.	25.00	25.00	25.30	25.30	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	881	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.38	0.70	-6.86	29	253	2009-01-15 18:05:59	2007-08-21 15:54:39	4	23	161	0	164	252	0	580.20	17	30.91	CHANGED	hhshhllhhllphhsGlsIppl...shhSl+tlshss+s.hpIpIctlthpl.....hspsphlplhshc.lclph........................pcpppppstpppsspttp................p.hthhphph.pphh+tlhphl.calphlslhlhpsslsh.shsptthshlphsspppphhhsp.......................hph.h..lpslhhthps.....tp..pllspsslslpshlphsh.......sLcshslslpluclplPhs..shhphhthhcp.cpptspt....t...t................................psppthpplp............p.hchhpplhchlp-lplplcphpl.ch..s.tsp..sh..............lsh+plshshp+hsppsPua+hhFppc.Dhshphhhshhslplths.t........ptpsscllplPssohohcoshhp.h..........ts.spspthps......................................sllphshslooPslDlphcplshlhshhtshhhh+ph.shsptppp.............................................................h.hhpchhPphshKhslc-Phlhlphs..t.s.......hshlhtShSslshslposc...........ttptplhashhophpltshphhhps..spth+pslhphcshphch.hshhsphplphpsslss....hshchsphcl.hpulppllhplstphp.c..hthptp............................................c.plh+tLPsaltphphphoslshplus..............spslp..-htcGlshcLcshsspacthphsh.sshpthppps.Sps.s.hps................t.pt.ths-hpphs.p.p......................................sh.s.h.psscph.hcshhslsph-ltlsshscp......sshhplphplpplhsphshaphashhsulshlpphhht..tshppppppsp.hphtt........................................th.chlplchchpslplhhpLPs-sshhlplhs	....................................hhhhh.h.ph.stlpItph...thh.lptlshp.pp...p..lplctlhhp..........phh.lh..p...l........................................................p....................................................th....thhphhhp.h..ahp.lslhh.pssh....ht.......t.h.hhhspptp....................................lpph.h..............p...phlsph.shthphhh.hsh........shp.hshslplhphph.hp......h.......t...............................................................t.t.h.p.h..................hh....h.th.pphphthp.hth.........t.........................h.hp.lth.hp+.p.p.s.hp..Fp.p..shs......hhhp.sl.h..............ttp.pchh.ls.hphshpss..................................................................h.hphslsos.lchc.pphshhhthh.......pt....t..hp............................................................................................hhs.h.h............................hh..p.o.h.hshp.......................hhh...t.....t....h.......t....thh..p.hth.................ht................h.....p..h.......hp.hh.ph..............................................................hhp.hP.....h.ht.t.h...hs................t..p....p..pu....phtthshph.....t....................pt............................................................................................................h..h...p.h.h.s.st.........s...lp..h.th...hp...hhh.h.sh.hlpphh..........................................................................phhthsht.t.ht..h.hstt..hhhp................................................................................................................................	0	21	55	113
+10177	PF10345	Cohesin_load		Cohesin loading factor	Wood V, Coggill P	anon	Wood, V	Family	Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4 [1].	21.30	21.30	21.30	21.70	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	609	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-12.82	0.70	-6.31	21	268	2012-10-11 20:01:01	2007-08-21 16:06:20	4	10	212	0	192	312	1	467.70	23	69.21	CHANGED	ptph.hLltlA-cahpsApshsspl....pptphppYapLlshulpCLpslhp............shpLssch-AplphcluplLhpETcNhspA-shLs..+uhhlspp..sshh-lKapsphLL...splhhcos.ps..Ahptlsctlp.hps..................pptahasachLphpLslpp...t-.stAhphLppltphss.psppthhlhhhhhpshlphhps.spDslphlpph.httpth.....t..ph.pLtshhhllclhttlppsp.tsspppLptlpphhpphps.........ass..ptchtl.lth.........................hhhhpWLspcplhhLsYhloulsthhcppss..+upKahpculpphcc.h.............sl..hppphthhpslphhhhhahhhpthhhsshtpsppphp.htshspt..........pthtshhhhLtGlhtQtp.......uchcpAhthah..........................................phstspssps-LtlhusLNlhhIhpt.spppptp........................hsplhsplcshsspssspphthstshh..ltshpth.shphp......pp+pphppsLpth....p...................thspsphhshsLsllstpha.......tssst..........Epsphstp...uhphAppp................................................pstLWh.lssshhtp.hc.tGptsctcpstpphpplpp	...................................................................p.....lhthAc.hhpts...ht.h....................lpCLpslh..............php..s..p.EuhspLphuplLhpcTp.....N...p.AcphLp......+uh.....lspp..........ph.-lKapht...LL...splhhpps.hs....Ah.hlcp..hlp..pt.........................s.hath+h...l...hpls..h.....p-hstAhp.Lthhsp..hup......ssthh...hshhhl.cu.hlh.h..h...p.t...t-.sh..hlp.s....sp.h.......p....ph.....pLp.shhh..hlpls.h.l.tt.phppsp.pLptlpp.hpph.p....................tp..h..t.................................................................hh...pahspcphhsLsahl....o.sht.h.t..........s..p......+up+ahpculh.lpp.h..........................................................h.pp...hhp.h.h.hh.hhhhhthshsp.hth.s.ptht.htp................................t.h.s.hhhh.uhh...sh.......sphptA.t.a............................................hh.p.s.p...p-lhhhhshNhh.lh.t.tp.tp.............................h.plhptlps...tp...s.......sp...h......hshhhh..htsh.t...h..................ptKp.lppsLphu......p.......................t.s.sphhshsLs.hhshhhh........ssht..........Ep.phss....uhthAp+.................................................tstLW...ssshh..tp..chtspt.ctpthht.h...............................................................................................................................................	0	54	99	157
+10178	PF10346	Con-6		Conidiation protein 6	Wood V, Coggill PC	anon	Pfam-B_35316 (release 21.0)	Family	Con-6 is the conserved N-terminal region of a family of small proteins found in fungi [1]. It is expressed at approximately 6 hours after the induction of development and is induced just prior to major constriction-chain growth [2].	25.00	25.00	25.80	25.30	23.30	24.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.16	0.72	-7.45	0.72	-4.54	23	178	2009-01-15 18:05:59	2007-08-21 17:03:05	4	5	51	0	145	192	0	35.80	43	41.08	CHANGED	c-ssNlhtGaKA.............sL+NPpV........SccuKc+AcchLcchss	..................ts.sNVhtGhKA.....................slpNP....sV........S-cAKp+A+chL-pht.......	0	78	101	134
+10179	PF10347	Fmp27_GFWDK		RNA pol II promoter Fmp27 protein domain	Wood V, Coggill PC	anon	Pfam-B_5282 (release 21.0)	Domain	Fmp27_GFWDK is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic GFWDK sequence motifs. Some members are associated with domain Fmp27_SW (Pfam:PF10305) towards the N terminus.	20.30	20.30	20.50	20.30	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.01	0.71	-4.25	33	294	2009-01-15 18:05:59	2007-08-21 17:12:47	4	35	229	0	216	303	1	141.10	33	5.80	CHANGED	DYPLPllphP....sps.ph.shphpGslVluEphhps.cphRplhVPlsPsst.ptt...sshaulpl.RTlosVKhasDhphclsospsoplsWGtSYQPAlpphMtshDpFoKPslDPSs+lGFWDKlRLlhHG+hphphpp..phclthKGS...........+DPYpl	...............................................DYPhshhpl..................shplhushlhuEph.ps.cuhRphhl.ls.............pshhsltVpR....oh....sPlKhYpDhphclpo...splsWG.suapPuhpphhhsh.................-............t..ho.....K..........P....s....h....D...........PS.................t...luaWDKhR..LhhHG+hphshcp....hplph+uo...........cDPYph................	0	64	115	183
+10180	PF10348	DUF2427		Domain of unknown function (DUF2427)	Wood V, Coggill PC	anon	Pfam-B_52268 (release 21.0)	Domain	This is the N-terminal region of a family of proteins conserved in fungi.  Several members are annotated as being Ftp1 but this could not be confirmed. The function is not known.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.24	0.72	-4.46	33	258	2012-10-03 10:28:09	2007-08-22 10:51:40	4	7	134	0	196	274	0	100.80	27	18.68	CHANGED	shsssoaassspstcusLahHIhlhsluashlaPlullLuhs+.S+aalssphlthslslsGhhhutl.apuppPp...hYssNsHsphuhlLhhhhssQhshulhhpht	...................t...s.s.hh..tp.hcuh..lhhHIhlhsluasllaPl............u.h.l....L.....uhs.+...S.......R.......a....al..P...s..QhlthslshhuhhhG....t....l.....apupp...........hh..ssN.....sHsphuhllhhhhhsQllhGlhhth..........	0	51	107	162
+10181	PF10349	WWbp		WW-domain ligand protein	Wood V, Coggill PC	anon	Pfam-B_5077 (release 21.0)	Domain	The WWbp domain is characterised by several short PY and PT-like motifs of the PPPPY form. These appear to bind directly to the WW domains of WWP1 and WWP2 and other such diverse proteins as dystrophin and YAP (Yes-associated protein). This is the WW-domain binding protein WWbp via PY and PY_like motifs. The presence of a phosphotyrosine residue in the pWBP-1 peptide abolishes WW domain binding which suggests a potential regulatory role for tyrosine phosphorylation in modulating WW domain-ligand interactions.  Given the likelihood that WWP1 and WWP2 function as E3 ubiquitin-protein ligases, it is possible that initial substrate-specific recognition occurs via WW domain-substrate protein interaction followed by ubiquitin transfer and subsequent proteolysis [1]. This domain lies just downstream of the GRAM (Pfam:PF02893) in many members.	21.80	21.80	22.40	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.89	0.71	-3.20	31	266	2009-01-15 18:05:59	2007-08-22 14:06:34	4	9	168	0	161	239	0	107.50	30	39.43	CHANGED	PGGGa.Gp...spaKloFppGGAI-Fupthh+lsppsppu..ht.t...............h..shuhst.ss...Pshst......................................Ps.....................s.hssss...............ssssssa.sssssts.hhst...PP.PsYsus.....t	.....................sGGGa.Gp....spaKLoFpsGGAIEFuQthhpsssp.uppu..h.t.s....................h.ss...hshs..ss...sshsh......................................................hss.....Ps..................uhs..ss.........................................sssssa.ssss....s..s..s.hs..t...PPPsYsss...............................................................................	0	36	61	113
+10182	PF10350	DUF2428		Putative death-receptor fusion protein (DUF2428)	Wood V, Coggill PC	anon	Pfam-B_6748 (release 21.0)	Family	This is a family of proteins conserved from plants to humans. The function is not known. Several members have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these could be confirmed.	21.40	21.40	21.40	22.80	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.63	0.70	-5.36	33	333	2009-01-15 18:05:59	2007-08-22 14:57:58	4	9	254	0	238	352	4	254.50	26	17.08	CHANGED	hcphhscllshspplhphl+sllsp-o...PEGt..........................................hs-pht.......p.shssphllshuWRul+E..uShLLtsll...............................sshlotsplctlGphhhppLtpl+HRGAFpsVh.sFsshCpphhp.....spstplssLPppWLppslphlpsp...........sph....hTRRSAGLPahlsuILsucsss.......shhppshppLlclAchsst..........tsttt...p...............lPQVHAhNsl+sIFpsscLustsssaltcuLpLulcs.FsSssWu	................................................................................................................................hhpcll.hs.pl.ths.t.sll.sssu.......PEGh.....................................................................................spphp............pttsssphlLs..ssWRuhKE..s..uh..LLs..t.lht.h..h...................................................................t..s.sthl..shpp.l....cpl.Gphhh.ptLhphRH+GAFptsh.uFspl...spthhp.............sp..s.....sp..h.....p.p..L..PppWlpp.hlpt.l.psp..........................ssh..phTRRSAGlPhhltulLsu..-sppt..........sllppsh.ppLlp....lAp..sss......................................tt..p.....................................lPpVH..A..l..NhL+slFpco...pL...u...p..ps.s.a...ls.cu.h.phAlps.hsSshWs.....................................	0	85	128	197
+10183	PF10351	Apt1		Golgi-body localisation protein domain	Wood V, Coggill PC	anon	Pfam-B_6317 (release 21.0)	Family	This is the C-terminus of a family of proteins conserved from plants to humans.  The plant members are localised to the Golgi proteins and appear to regulate membrane trafficking, as they are required for rapid vesicle accumulation at the tip of the pollen tube [1]. The C-terminus probably contains the Golgi localisation signal and it is well-conserved.	20.20	20.20	20.20	20.40	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.32	0.70	-5.63	41	368	2009-01-15 18:05:59	2007-08-22 15:48:38	4	35	242	0	260	388	2	417.80	21	19.93	CHANGED	llp+sShhh....hYsphsshthp.............ssttphcs...........hcplslphPclhssssSpQYhs..lYsIltsLLhas-Phccph.pc+lc+lhhshDhp..Dlpuhs.phlppLQpcl+pLtplppphph+pphLspps....................................htchhhlph-htpstt-Lhhlhpslpssptc..........pp...sspsshpaplpsccllW+llc-sppPhl.-htLssspapRpcsscGSshNplplphlpshNLh.sAhYspllsPa.p.............s.psscpshlclpWphttslGGIsVh-chclslhPLplpl-cchsc+lhpYlFPsppsp....................cpssspctpppsthshsstsssptstps.........................................................................................pt.t..s.tph.spssppt.pspc.tht...................p--lscMhpRuppahsltpl+lsshhlplSYK.....Gpsptpl.sVpDhhhplPslcYcNpshohhDLhhplKKcll+sllpHsG	............................................................................................llppssh.hhY.phs....p..........................t.....t............t.hcphtl.h.p.l..phtssu..tQY.h..hh.ll.sL.Lhas-..P.cc.h.pc+hp+.lhht.-hp...shtt...p.l.phQptl+....p....h.thh....pp.....hphp..h.l..ppt..............................................................................................................ph..hptp.hthptt.....cL..hhhpshpptphp.....................................tp...ssphhhphphthpphhWc.hhpcp........sp...........h..l..-htlpph.a.........s+hppt-.........sos.p...hlplt.h.hhNL......h......s..ss..hY......p..l..ltPh.s................t.scp.hlclh..hp.......hh.sluG.I.s.lh-.p.FE...lslhPLplpLpcphhcchhpahFPs.t............................................ctppspptppts...h.h..ss.sssp.tt..................................................................................................................................................................................................................s......pt.st....s...ttt..pt..ph...tht............................s--lscMhpRupp.....hphh.lKIspl..lplSYK..................Gptp...........t.....sl.....p-h.hhhPslcapNpTaohhDhhhtlK+chh+sllpps..................................................................................................................................................................	0	84	144	224
+10185	PF10353	DUF2430		Protein of unknown function (DUF2430)	Wood V, Coggill PC	anon	Pfam-B_67886 (release 21.0)	Family	This is a family of short, 111 residue, proteins found in S. pombe.  The function is not known.	24.60	24.60	24.90	210.00	24.10	24.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.50	0.72	-3.87	2	3	2009-01-15 18:05:59	2007-08-22 16:11:30	4	1	1	0	3	3	0	107.00	75	94.13	CHANGED	MLLLhhICClFlKhlLApVsLTFV-YAKLPspYAELLANhhsQpGlMLFsTuDlRItAYNYLlNslTEhNsDTDAYLCQLLTGQYTTDCYIFssss.-tPEshNsSh	MLLLFCICClFIKLVLAEVNLTFVDYAKLPPKYAELLANLTDQHGlMLFDTADVRIEAYNYLVNNITEINTDTDAYLCQLLTGQYTTDCYIFDDSVYEGPENINPST	0	3	3	3
+10186	PF10354	DUF2431		Domain of unknown function (DUF2431)	Wood V, Coggill PC	anon	Pfam-B_6967 (release 21.0)	Domain	This is the N-terminal domain of a family of proteins found from plants to humans. The function is not known.	24.70	24.70	25.70	25.00	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.31	0.71	-4.29	47	435	2012-10-10 17:06:42	2007-08-22 16:42:22	4	23	253	0	309	432	13	160.90	28	42.77	CHANGED	LlVG-GDFSFuhuLhppht...sssLsATohDot.ppLppKYs.pht..pNlptL...cptGspVlaslDspphtpph...........................hpppp.FDpllFNFP.Hs.........G...tt.tp.....sppplp..............tppcLlhsFFpsupplhpt...................................tGclhlohtsGpP................Y.spWslc.tLAtc..sulplhcphcFphp..saP..GYcp+cs	........................................LllG-GsFSFuhuLh......p.......t.......ht........................st.....p..lhATsh-s..ppl...........htcYs..pst......psl.ptL.....cp......s....s..pl..h.aslDspphtpth..................................................................................ptt...aDpIhFNFP.Hs..................................G............pttlt...............................hpppLl.htFFp.s.stph.l.t.................................................................................tGplhlohhpsps........................a.s.Wpl.....thAtp............suhhl..pt.h.Fphptas....GYpptt.h......................................	0	87	175	257
+10187	PF10355	Ytp1		Protein of unknown function (Ytp1)	Wood V, Coggill PC	anon	Pfam-B_7247 (release 21.0)	Family	This is a family of proteins found in fungi. The region appears to contain regions similar to mitochondrial electron transport proteins.  The C-terminal domain is hydrophobic and negatively charged. There are consensus sites for both N-linked glycosylation and cAMP-dependent protein kinase phosphorylation [1].	25.00	25.00	29.90	48.70	21.30	22.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.82	0.70	-5.19	36	273	2009-01-15 18:05:59	2007-08-22 17:18:04	4	5	134	0	199	267	0	266.30	38	48.98	CHANGED	lhuaVpl...shGslshhGascGpclhssLAHaIhGulFhhYGll.hu.hhGhhhphGhAW....................................ch...t.................ptthStEFh-ShlIhhaGssNsFhEHhuutss....WotpDLQHsSlullaauuGLsGlhlpppt.........................................................s.thuhNshPullIhhTGhhMSpHpQps.lSThlHt.aGhhLhuuuhhRhlphhhlhhcss..................ss.shsspsshphlssFsLlsGGllFMtSo--hlpshcthGh.sthhhhslshuhshLlhsWhhlLlt.l+sa	.....................................h.hualphhhGslshhGas+usclhpsLAHaIhGusFhhYGll.....hshhh.lG.sW...........................................c.............................p.sshStEFh-ShlIhhaGs..sNsFhEH..hhG.ts.....WotpDlQHsohu...llaauuGLsGhhlppcp...........................................................s.t..phN.lPullIhl.TGhhMSuHsQp.hlSThlHs.aGhhLhuuuhsRllphshlhhc.s.......................................ss.shssh...sshp.hlssFsLhuuGllFMsu......T--plphhpphGh.sthhhhhlhhuhshllhhahhlllt.lhs.............	0	50	107	167
+10188	PF10356	DUF2034		Protein of unknown function (DUF2034)	Wood V, Coggill P	anon	Manual	Family	This protein is expressed in fungi but its function is unknown.	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.38	0.71	-5.12	11	178	2012-10-11 20:44:46	2007-08-23 13:34:52	4	3	128	0	140	242	59	117.60	28	61.05	CHANGED	STlapGTLYEhpVtphLpppLtshsLc+sGGutDuGlDlhGpWslssh.............s......s..............................hpsLcVlVQCKuhps.KluP+hlRELtGoasphsst...p..pssTlsIlsSPp.hT+sulphhsphslPllah+lsh.p...................htDG....hphs.hNsstLptha.NshuctlL	......................................ossh.GshaEhhs.t.Ltph....hhpL.+hG..Gt.DtGlDlhG.W.ls......................................................................................t.lpllhQCKs.pt...+h..sPt.lREL..Gsh........th...t..........................t.th....h...hhhhs.p.hT.thh..h.p.t.....hPhh.....hh..h.........................ts.....................................................................	0	38	73	116
+10189	PF10357	Kin17_mid		Domain of Kin17 curved DNA-binding protein	Wood V, Coggill PC	anon	Pfam-B_7469 (release 21.0)	Family	Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle [1].	25.00	25.00	26.10	26.10	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.78	0.71	-4.49	30	331	2009-01-15 18:05:59	2007-08-30 09:51:48	4	10	284	1	245	323	2	125.20	44	35.57	CHANGED	Rphtlhup..sspphl-saSppFppsFlpLL+ppaGpK+lpANplYpEaI.pD+cHlHMN................AT+WpSLTcFl+aLG+pGhC+V--o...-+........GhaIpYIDpssEslp+pcthp++c+t-ps-E-pppchlpc.Qlc	.........................RQhhlhup..sspcalcpaSp-FppsFlpLL+ppaGpK+V.psNplYpEYI.u-+cHlHMN................ATpWtoLT-FsKaLGR.pGhC+V-ET-K.....................GhaIpaIDc..sPEslpRppt.hp++c+t-hsDEE+ptchIccQlc................	0	81	133	200
+10190	PF10358	NT-C2	Eeig1;	N-terminal C2 in EEIG1 and EHBP1 proteins	Wood V, Coggill PC, Zhang D, Aravind L	anon	Pfam-B_7857 (release 21.0)	Family	This version of the C2 domain was initally identified in the  vertebrate estrogen early-induced gene 1 (EEIG1) [1], and its Drosophila ortholog required for uptake of dsRNA via  the endocytotic machinery to induce RNAi silencing [2].  It is also in C.elegans ortholog Sym-3  (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1  (EH domain Binding Protein-1) that regulates endocytotic recycling  and two plant proteins, RPG that regulates Rhizobium-directed polar  growth and PMI1 (Plastid Movement Impaired 1) that is essential for  intracellular movement of chloroplasts in response to blue light [2]. 	25.20	25.20	25.20	25.30	25.00	24.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.67	0.71	-4.70	76	744	2012-10-10 12:23:49	2007-08-30 13:20:29	4	14	252	0	483	711	0	146.10	20	19.43	CHANGED	ppcphKaphplplcclpshst......................ssplhlph.+csspt..........................................ttpstph.lppspspap....pphphssplhhs.....tcst......hppKhhpl.lht.....................................tpspp......hlGpsslslupass.......................tpstspphhhpps.....tps.suplplslphp.hpts.pt	.................................................................................pt.Khph.hphpcl..s.sh......................sshlhlph.phhstt...................................................................................................phpsshtp......l.t......p.s..plpWp......cp.hphs.splhts..........spst.....................h.csp...hphsltpp..........................................................................................tsu+p....thLGpsslNLucassts........................................................................................tss.shph..hLcsh......ts..suhLplslph.hhpts.................................................	0	138	264	379
+10191	PF10359	Fmp27_WPPW		RNA pol II promoter Fmp27 protein domain	Wood V, Coggill PC	anon	Pfam-B_8838 (release 21.0)	Domain	Fmp27_WPPW is a conserved domain of a family of proteins involved in RNA polymerase II transcription initiation [1]. It contains characteristic HQR and WPPW sequence motifs. and is towards the C-terminal in members which contain Fmp27_SW Pfam:PF10305.	23.20	23.20	23.50	24.60	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	475	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.55	0.70	-6.08	29	179	2009-01-15 18:05:59	2007-08-30 16:16:13	4	19	134	0	139	186	1	450.00	27	17.85	CHANGED	GLKu+h-shhlDLHQR+E.hpphp.....ctLs..+pp+lh+h+hptu-lchpshDlRslsAtFppsshsshhpst.p..pt.......................................asI.DsD...hsWhDhcDFlElchhtspss.P.chcIhPLhaoP+FoYhRcsstpsp.sspst...........................FGsEsoHsChh.tpscPtpsQhcLlc-RlppLccplpphpctltphp...........s.t.p.tphcph.pplppLtc+lchlpshlpchpppp....ptpptssssp..tp.t.t..............................ssstpssusFcNRFhlHNhpLKWNsslRshll+YlHplspR+uhsaahSp+ulchlp-llccppctppssppphpp............p......ppsppss...........................pphh-ph-chLp-spp...............................s.sapsppsYhlclIuPQIQLpS-csPcusVLloA.shcl+llsl.....hDppssssslss.llppRaslhhcsuphFVhp+c-h.sh..thhassssYGsp....tosWPPWLslEls	....................................................................................................GlKs+h-shhlDLHQR+E.hpths.....cths..pp.pcs.ph+hptuplchtssDlRslsuthttsshpphhp..st.t...t......t...s................................phsl.D.pD...hsWhDh-DFlE.lphh...sp.ps.P...chcIhPlhasPRhoYaRpsshs.th..sps..........................................................................FGsEsoHtChh.tpscPtplQhpLlpcRlppLctphpphpctltc.p.............t.t.t...tphc.h.pphp.Lpp+hphlpshlpchptp.....ttptt..t.ss......tp..t.....t..t........t...................................................ssstphtupFcNRFhlHNhpLKWNsslRslll+YhapsspR+uhhaahSpcAl+hl.-llc...cptpsppp.pttttpp........................t.......tp..tpppss...........................psh..-phcplLp-spp..................................................s..chssppsYhlcLIuPQIQLpS.-....cs.c....usllloApshpL+llsl........hDppphs.s.slss.lVppRasl.hcssQhFlhppcph.p........h.hassstYGs.....tstWPPWlshEh........................................	0	38	79	125
+10192	PF10360	DUF2433		Protein of unknown function (DUF2433)	Wood V, Coggill PC	anon	Pfam-B_83000 (release 21.0)	Family	This is a conserved 120 residue region of a family of proteins found in fungi. The function is not known.	21.40	21.40	21.70	22.10	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.80	0.71	-3.83	10	111	2009-01-15 18:05:59	2007-08-30 16:29:41	4	7	104	0	85	111	0	122.90	51	18.13	CHANGED	YGlSYNEFSVssoh.......EsYRuKLupu+ssFs-lW-sVKsEV-.ssls........pp-sQppLLchuLulh-Kl.Psusssu.shhhshsh.ps.......tsAhh..shWpasLs..DuuaGphlLp.IsDu+luuEhpupGFNhucR	....................YGSSYNEFSVNPoL.......DHYRGKLAASKASFNDVW-TV+uEVE.sAIs.........pN-uQpsLLcNALslV-KM.PosAsGGN..PF.GG.Pssss.su...t.....GplDESAFK..NhWNFNLA..DAAFGaLVL-.IpsGRIuTEMRAQGFNFuHR...........................	0	27	50	73
+10193	PF10361	DUF2434		Protein of unknown function (DUF2434)	Wood V, Coggill PC	anon	Pfam-B_84994 (release 21.0)	Family	This is a family of proteins conserved in fungi.  The function is not known.	25.00	25.00	63.30	47.80	19.70	18.60	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.82	0.70	-5.35	10	63	2009-01-15 18:05:59	2007-08-31 08:48:38	4	3	61	0	51	64	0	270.70	46	54.05	CHANGED	YSNGTLSNGopCYLuFspapPph....hpNGTFlNGTSCYuPlpsIGs+uulGlAaAlhFululhlTLlNLRKHG+paLPs-KRaphl..................GRRhpWaWhLFluACGhISsFhoIDVDRsYL.usPllLpSlFapLhhPGhhAAVWEAVRHWGSWQERQllD..+DPaAFscsupRp+tEhlLPllFYlFshlNFFLsVPRSWouIEhQRs.-QphppApPsATDsRFKAAuFltluuhLllsYSLcHSIY+Y+s+spushsp.llFalptsPspFllsl.....sLsulplGYulAuAFsaslSP...L+hs	......YSNGTLSNGS..pCaLsFp.YpPth....hsNGTFlNuToCYsPlpslusRuulGluFAshFulslhhoLlsLpKHG+haLPh-KRah.l..................GRRWQWYWhlFlsAsuhlShFhslDVDR.YL.thsllLpShFaaLhh.uhlAhVWEuVRHWGSWQERQhhD...Dsa..shp.pcspRp+.EhaLPLlFYlFhaLNFFlslPRSWstlphQRo.-QphshAtPsATDsRFKuuuhhhhsshllIsaSLtHSIh+Y+s+spuhhsp.hhhh.lphsPh+Fhl..sI.....sLsulhluathhsuFpashSP...l+h........................................	0	8	22	39
+10195	PF10363	DUF2435	DUF2435; Pmp3;	Protein of unknown function (DUF2435)	Wood V, Coggill PC	anon	Pfam-B_7476 (release 21.0)	Domain	This is a conserved region of approximately 400 residues which is found only in eukaryotes. It is associated with HEAT domains Pfam:PF02985 in all members. The function is not known.	23.00	23.00	23.00	23.30	22.90	21.80	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.13	0.72	-4.09	40	249	2011-09-19 22:45:39	2007-08-31 11:17:15	4	8	223	0	180	258	0	93.40	27	9.87	CHANGED	ssppthccAlpsLsDPLlPlRA+GLhhLppLlppcS...............slhslstlLslaLppLcDp.......DsFlYLNuI+GLusLs-hpsc.plLppLsphYsspspp	............................................s..pthpcslppl...p..D..s...sP.lRAtGLphLppLlcpcs............................slhp.h.ptlL.p.lhL.p.tLpcp.......DsalYLsuIps..l....ssLushh.Pc.plltpLhcpYhstp..p......................	0	57	93	146
+10196	PF10364	NKWYS		Putative capsular polysaccharide synthesis protein	Wood V, Coggill PC	anon	Pfam-B_99492 (release 21.0)	Family	Found only in Vibrio species, pombe and one other fungi, this is a the N-terminal 150 residues of a family of proteins of unknown function.\	   There is a characteristic NKWYS sequence motif.	21.40	21.40	21.90	31.50	19.20	20.80	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.85	0.71	-4.44	6	61	2009-01-15 18:05:59	2007-08-31 15:01:44	4	5	39	0	17	63	6	135.80	35	42.11	CHANGED	s-thhpDspshchERsphLhE.sF-cahNppYshpWFDNEIKplhGIDVaspsFspssGaQTapNcphSllVI+s-KLsp.tspslu-FLs.pshslVp-NpucNKWYSslhp-FKsoYp.ss.Fl-cMhsS+Lo+HFaops	......................h-thhpDs.thc.-hs..h.E.sF-p..ahNhpY.hsWFDNElKpshGIDVhppsFDpspGa.s..apscphslllI+sEpLsp.hspslu-F..Lsl.p...shslp.p.sNpucNKWYSs..lapcFKppaphsptahppMYsp.Lh+HaYop......	0	4	9	13
+10197	PF10365	DUF2436		Domain of unknown function (DUF2436)	Mistry J, Wood V	anon	Pfam-B_5683 (Release 22.0)	Family	This domain is found on peptidase C25 proteins and has no known function.	25.00	25.00	25.40	33.50	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.98	0.71	-4.61	3	36	2009-01-15 18:05:59	2007-09-05 10:47:55	4	9	9	0	3	38	1	156.60	60	14.28	CHANGED	ARpVcGIu-ulhVolEDAs-.lRoGpAcIVLsAcsVWsDuSGYQFLLDADHDTYGsVIP.DTGPLasNsoVPSNLY.AsFEYpIPuNADPusoTQNhIssG.oAcVsIPuGTYDYsITNPpP.suKlWIAGsGGspPARhDDYVFEAGKKYTFTM+KsGSGDGT-L	................uRpVctIt-hlhlolcsAs-.lRA.spA+lVLtAcsVWGDsTGYQhLLDADHNpaGuVIP.sTGsLas.s.ossusLY.AsFEYhlPuNADPssTspNhIlsG.pupVsIPuGsYDYsIsNPpP.suKhWIAGDG.stPuRhDDasFEAGKKYpFTM++sG.GDGT-h..........	0	3	3	3
+10198	PF10366	Vps39_1		Vacuolar sorting protein 39 domain 1	Mistry J, Wood V	anon	Manual	Domain	This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex [2].  Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [3].  In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange [1].  The precise function of this domain has not been characterised.	21.40	21.40	21.40	21.50	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.46	0.72	-4.03	23	369	2012-10-11 20:01:01	2007-09-05 13:18:27	4	21	253	0	253	369	0	105.10	34	11.14	CHANGED	lDTsLh+sYhhs.pssLlusLLRl..NaC-hchscphL.............ccpppap-Ll-hYas+phHccALcLLpcluc.............ttss.hpshppt.......lpYLppLssspl-Llhc.....aucWlL	....................lDTsLh+sYhts...ss......s.........l.lusLlR..........lt..NaC..clccs....pc.hL.............ccpp.+as-Ll.LYp..tKshHccALplLh.chup..........................pts.sshpshpcs.......................l...pYLppL.s..s..ppl....cLIhcautWlL.............................................	0	75	128	200
+10199	PF10367	Vps39_2		Vacuolar sorting protein 39 domain 2	Mistry J, Wood V	anon	Manual	Domain	This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex [2].  Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [3].  In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange [1].  This domain is involved in localisation and in mediating the interactions of Vps39 with Vps11 [1].	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.39	0.72	-3.88	24	612	2009-09-13 14:58:24	2007-09-05 13:18:58	4	31	283	0	445	603	4	104.40	22	11.03	CHANGED	LclLspHus+lsshpsLpL.............LPsshslpp......lpsalppslRppsppp+psplhpsLhpucplpspcphh..............ptcspplhls-pph.CslCcK+lGs.SsFshaPsu.slVHatCtcc	.........................plLppaus..pl.cst.plLpl.............l..Ps..shslpp...............lps...aLtpsl.c..p.ts.p..ptc..p..splhps....Lt.p.u..c..t..l..p..lp.tc..hh.........................pt.pp.pthhl.sp.pph.C.hCpc......tl......s...........s......s.....s.........hsh.a..Ps.s...hhh.Hh.C...p........................................	0	180	269	381
+10200	PF10368	YkyA		Putative cell-wall binding lipoprotein	Coggill PC	anon	Gene3D, pdb_2ap3	Family	YkyA is a family of proteins containing a lipoprotein signal and a hydrolase domain. It is similar to cell wall binding proteins and might also be recognisable by a host immune defence system. It is thus likely to belong to pathways important for pathogenicity [1].	22.00	22.00	22.10	22.00	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.32	0.71	-4.98	17	458	2009-09-13 15:40:04	2007-09-05 15:38:52	4	3	358	1	37	198	2	195.40	42	93.56	CHANGED	shhuhhlLsGC.hspcst-plasthEpAscpE+.shppptcpLppLEcccpcLYppllp.sh-c.cplhphs-pAlpsspcREchlppEK-ulccupcEhcsscphh-cI-Dcch+cpAcplscshccRYcuapphhcsYpculph-K-LYphLpccchshcpls-plcslNpsYcclpctpccFNchTccYNctK.sFYctutlc	.................................................................................s.hhSssLLAGC..hscK.....csh...h...pth-phtcpEc.slhssuKKlpcL-cctpcLappl.....spc..cstshtKtlcphlcNsD-RtK.hcKEc-ulcKupp-hKpAcsal-pI-sc....th....+Kp....scpl-cshKc+YchaschscuYpKAl....spEKpLachLppp..-sp.pslsEKsKslspsYKclpc.p-caschhpchscEK.sh.p.....................................	0	7	19	28
+10201	PF10369	ALS_ss_C		Small subunit of acetolactate synthase	Coggill PC	anon	Gene3D, pdb_2fgc	Family	ALS_ss_C is the C-terminal half of a family of proteins which are the small subunits of acetolactate synthase.  Acetolactate synthase is a tetrameric enzyme, containing probably two large and two small subunits, which catalyses the first step in branched-chain amino acid biosynthesis. This reaction is sensitive to certain herbicides [1].	22.60	22.60	23.00	24.00	21.80	22.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.13	0.72	-4.25	160	3802	2009-01-15 18:05:59	2007-09-06 10:36:43	4	13	3503	7	996	2241	1813	73.70	39	42.97	CHANGED	cRELhLlKVpu.ss..psRsElhplsclFRA+lVDVstco.hslElTGsssKlcAhlcllcs.aGIhElsRTGhlAls.RG	..........pRElhLlKVpA..su.....psRs....Elhchs.clF....Ru..pllDVoss..s.hslp.l.........oGsscKl-Ahlphlcs..hu.I.hElsRoGssulsRG........	0	309	658	854
+10202	PF10370	DUF2437		Domain of unknown function (DUF2437)	Coggill PC	anon	Gene3D	Domain	This is the N-terminal 50 amino acids of a group of bacterial proteins annotated as fumarylacetoacetate hydrolase-containing enzymes. In most cases members are associated with FAA_hydrolase Pfam:PF01557 further towards the C-terminus.	21.30	21.30	21.30	21.50	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.24	0.72	-3.58	44	659	2009-01-15 18:05:59	2007-09-06 11:59:18	4	1	623	6	229	541	241	53.70	35	20.45	CHANGED	M.+lsRF....sssss.spaGhlE.G-s........lt..lsGsP.F.sshp.TGpphsLu-..V+LLAP	............M.RluRF......stsss..ss...aGhl-..sss................lt..lsGcP..a..u.......ss..ph..T.......G..pp.asLs-..VRLLuP.............	0	74	162	205
+10203	PF10371	EKR		Domain of unknown function	Coggill PC	anon	Gene3D, pdb_2c42	Domain	EKR is a short, 33 residue, domain found in bacterial and some lower eukaryotic species which lies between a POR (pyruvate ferredoxin/flavodoxin oxidoreductase) Pfam:PF01558 and the 4Fe-4S binding domain Fer4 Pfam:PF00037. It contains a characteristic EKR sequence motif. The exact function of this domain is not known.	19.40	19.40	19.40	20.30	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.90	0.72	-4.40	113	1931	2009-01-15 18:05:59	2007-09-06 16:54:57	4	33	1656	20	330	1395	43	62.40	40	5.31	CHANGED	ss....ttp..tts........hst..ps.........P.........cFVpplhtshhutcGDpLPVSuhs....tDGTaPsGTupaEKRsIAl	..........................................ssps..........hhss...ss.....P..........-FV+slstsh.AtpGDsLPVSAhs....sDGTaPhGTopaEKRsIA......	1	159	261	304
+10204	PF10372	YojJ		Bacterial membrane-spanning protein N-terminus	Coggill PC	anon	Gene3D, pdb_2fb5 	Family	YojJ is the N-terminus of a family of bacterial proteins some of which are associated with DUF147 Pfam:PF02457 towards the C-terminus. It is a putative membrane-spanning protein.	20.10	20.10	20.20	23.20	19.80	18.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.31	0.72	-4.11	6	127	2009-09-11 10:46:57	2007-09-06 17:03:14	4	1	127	3	15	76	0	68.40	58	33.78	CHANGED	McphphSEtpaKsphppalcpIpt-huhlhpTlDEcDpClLC-hE-LpHhhs-hQslASSaYLQoYlp.F	..........MpEWGLSE.ELKIQTKQMIElAE+ELS....lMRpAID..KEDECILCKMEDIHHhLuNVQTLAATYYIQAYLSPY	0	5	9	10
+10205	PF10373	EST1_DNA_bind		Est1 DNA/RNA binding domain	Mistry J, Wood V	anon	Pfam-B_24280 (release 22.0)	Domain	Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1][2]. This is the DNA/RNA binding domain of EST1 [3][4].	21.20	21.20	21.20	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.67	0.70	-5.19	69	696	2012-10-11 20:01:01	2007-09-07 14:14:08	4	18	255	2	489	771	76	252.20	17	29.44	CHANGED	AhpYYphAtplhPssGpsaNQLulluhh.s...ssc.......................hpAl.YaahRSl.hsppPh.ssApsNLhthacc..........................................................................htphhptp.ht..........pttphhpphhhhFlpLhuhhaps..........hshpphspltppl..hpplphhLpp.........................................thhstphll+hlslslhshchhpp..................................t.......s...hphhhthhthlhpphsphh.............................pptsssspphLssl+l..hhsW..lttpsshhp...............ptpptphtt...hhthhsphlshhpth.....................h.sppts...pshhL.EDhp.......hpuFtPlttsh	...................................................................................AtpaYhpAhplhPps.Gp.sasQLAlLuh..p.........tpp......................................lpsl.a.aYhR....ul.ss.p..P....a...sAppsL.phhpc........................................................................................................t.p...............ptt..hpp..hhh..Fl.thpuhl.aht.........................shp.....p..h..t.t..htpph...............hpph.ph..hl.p.............................................h.st..h....hphhh....ls.hhshpthp..............................................................................p.....hthhht.hhthlhpth......................................................................................................t.......t..Ls.lph.....ta..hh............t...h..........................................................................h...h...hh............................................h.h.E-.........h.th.......h...................................................................................................................................................................................................................	0	147	237	365
+10206	PF10374	EST1		Telomerase activating protein Est1	Mistry J, Wood V	anon	Pfam-B_39673 (release 22.0)	Domain	Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1][2].	21.70	21.70	21.90	21.70	20.90	21.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.52	0.71	-4.16	27	478	2009-01-15 18:05:59	2007-09-07 15:36:39	4	10	230	2	319	468	0	120.60	24	12.61	CHANGED	ttpclcphLWcphaYplhpha+ph..................tpp.ph..phcplppth.palcpuhtFYpsllppltspYp.ls.hphh.......................................................................t....t.pth.thssph.phslhssaRsLlhLGDlpRY+s.htpss	...............................................h..pplEphLWppsahphIpt.h+t...............................................tpppps..sptp.clp..st..hppa.LctupsF....Ypp..Llpclps.pap..lpl.phh.................................................................................................................t......t.tt.p.t.hs.s.hsp.tt.hp.h...s.hh.ssp+CLlpLGDluRY+ppht...s............................................................	0	90	150	233
+10207	PF10375	GRAB		GRIP-related Arf-binding domain 	Wood V, Coggill PC	anon	Wood V	Domain	The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localised to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane [1].	19.70	19.70	20.90	20.80	19.60	18.30	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.23	0.73	-6.26	0.73	-4.00	14	129	2009-01-15 18:05:59	2007-09-07 16:52:08	4	3	124	0	96	131	0	19.00	51	3.40	CHANGED	psccsVD+clloNlllsFL	...ps--sVD.R...cLVTNhlLpFL	0	28	56	83
+10208	PF10376	Mei5		Double-strand recombination repair protein  	Wood V, Coggill P	anon	Wood V	Family	Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.	21.10	21.10	21.60	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.41	0.70	-4.82	8	105	2009-01-15 18:05:59	2007-09-07 17:46:31	4	3	85	0	69	109	0	182.80	26	84.00	CHANGED	ssslssppssh.h.pt.ssss.pstps+pPhusoL+E+L..+csRhpppshss.lKcl+l-spcscpshst.sts.............cph-SEspppps...h.c.+slCp.-ppphpsuosstls+..uhpchh+ccLcpcKt+Lp+Qlc-..........cpDpLRRLclV+hhchKNp.pcLppLI+KW++suQptLpcLpuhlu-..............pEs-..........chTLoELlspaGlD.sLlaaN	..............................................................................h................................h.tshtp.h..........pcht.p.pp...hp.hp.hp.cppp..p.t...........................hh.st..pt.p..p.h..p.hshs....p.p..h.ssshs..t.hp.p.h.s.pch.cpplpp.-Kt.......+L....cQlp-...........cc-hLR+LchVcha+.tKsp.ppLptLIcKWRsssQ.hLh...-Lp.pth.sp..........................................................-sc.................chohspLlcphslD.pLlaa....................................	0	21	32	49
+10209	PF10377	ATG11		Autophagy-related protein 11	Mistry J, Wood V	anon	Pfam-B_21462 (release 21.0)	Family	The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex [1,2]. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy [3].	21.40	21.40	21.50	23.60	20.30	21.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.94	0.71	-4.25	28	284	2010-01-13 17:17:44	2007-09-10 14:03:15	4	6	233	0	202	291	0	141.20	27	11.99	CHANGED	apsulh+RhcDlEph.....A+KlpK-s+stcpchpphtpc...KIuhcsFchGDLsLFLPTRpp..................................................................tt.ps................WAAFNl..usP+YFL+spstt.................................plcs................+-WhlGRlsclEcpsV.......................................s.cssNPFcLucGspWYhV-App.	.........................................................................................cph.p.+p.hpt.pp..p....hp.phpp-...........KIuh+sFphGDLsLFl.scpps....................................................................................................................................asAFsl....usspYFL+ppsht......................................................plps.............+sWll.u+lhchEpphsc.........................................cspN.acLshGs+aYhlcss.....................	0	59	107	164
+10210	PF10378	RRM	RMM; 	Putative RRM domain  	Griffiths-Jones S, Coggill PC	anon	Griffiths-Jones S, 	Domain	This is a putative RRM, RNA-binding, domain found only in fungi. It occurs in proteins annotated as Nrd1 yeast proteins, which are known to carry RRM domains.  It is not homologous with any of the other RRM domains, eg RRM_1 Pfam:PF00076.	19.30	19.30	19.60	22.50	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.66	0.72	-4.38	7	104	2009-01-15 18:05:59	2007-09-10 15:38:39	4	10	104	0	79	99	0	54.50	47	6.11	CHANGED	.hP....hP.TPFDhsYGtSLLPSpLLhGSPalssPtpsssh.usphusthshstpphp	.........t.........PsT.s.FDMsa.sPLLPSQLLlGSPF..QPGoPuuF.sSPQFpshtshtptp..t..........................	2	12	38	65
+10211	PF10379	nec1		Virulence protein nec1	Mistry J, Morningstar A	anon	Pfam-B_11405 (release 21.0)	Family	This is a family of virulence proteins that are found in pathogenic Streptomyces species.	20.00	20.00	20.60	24.50	19.30	16.50	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.28	0.71	-5.01	2	20	2009-01-15 18:05:59	2007-09-12 16:07:43	4	1	14	0	1	7	0	165.00	91	84.55	CHANGED	hNLKIRTLGDLMRTSGVTPKTQSSSPKRRVLTSLATILAASGVVVANPSAAFANSTFTAVGYCDTNYQCAGGSGSSSRWSVNFDDGPTVSTIDLHELYRDQSDTMSSFRILGSVMSRANHPNETVTIHQQFYRDNGGQVPLGEYETRFRASSSNNAQRFNFDQGIPNLPWNDQVSSVAIWITRK	.........VNLKIRTLGDLMRTSGVTPKTQSSSPKRRVLTSLATILAASGVVVANPSAAFANSTFTAVGYCDT.NYQCAGGSGSSSRWSVNFDDGPTVSTIDLHELYRDQSDTMSSFRILGSVMSRANHPNETVTIHQQFYRDNGGQVPLGEYETRFRASSSNNAQRFNFDQGIPNLPWNDQVSSVAIWITRK............	0	0	1	1
+10212	PF10380	CRF1		Transcription factor CRF1	Mistry J, Wood V	anon	Pfam-B_25525 (release 21.0)	Family	CRF1 is a transcription factor that co-represses ribosomal genes with FHL1 via the TOR signalling pathway and protein kinase A [1].	25.00	25.00	32.80	32.80	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.81	0.71	-3.78	13	51	2009-01-15 18:05:59	2007-09-13 14:50:17	4	1	43	0	32	51	0	121.50	44	16.05	CHANGED	sESTDE...............D-oLP...................ssss+s+h..hupKAKEVLSS.............................................................pssshRPPhLGTW.phDsKPFuIIDGLST+SL..................hs..ppppp.p-............p..........................ptst.sss.pppssssus-sssLs.....................LsELL.............................................Nh.............SELDD-	....sESTDE...............D-sLP...................sPss+pKp..hupKA+El..lSS.............................................................pslG.l+PPKLGoW..ph-s.KPFoIIDGLSTKSL........................ash.pptpp.pp................................................pppspss...pppppssuspsspLs.....................LsELL................................................Nh..........SEL-s.....................................................................................	0	6	18	30
+10213	PF10381	Autophagy_Cterm		Autophagocytosis associated protein C-terminal	Finn RD, Wood V, Coggill PC	anon	Pfam-B_10019 (release 7.3)	Domain	Autophagocytosis is a starvation-induced process responsible for transport of cytoplasmic proteins to the vacuole. The small C-terminal domain is likely to be a distinct binding region for the stability of the autophagosome complex [2]. It carries a highly characteristic conserved FLKF sequence motif.	20.10	20.10	21.30	22.70	15.80	19.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.65	0.72	-6.81	0.72	-4.82	20	317	2009-01-15 18:05:59	2007-09-18 14:32:30	4	5	286	1	226	312	3	24.90	65	7.80	CHANGED	Vc.YLhlFLKFlsSVlPTIEaDhTh	...Vc.YLllFLKFlsSVlPTIEYDaTh..	0	80	125	186
+10214	PF10382	DUF2439		Protein of unknown function (DUF2439)	Mistry J, Wood V	anon	Pfam-B_19050 (release 22.0)	Family	Proteins in this family have been implicated in telomere maintenance in Saccharomyces cerevisiae [1] and in meiotic chromosome segregation in Schizosaccharomyces pombe [2]	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.89	0.72	-3.77	22	223	2009-01-15 18:05:59	2007-09-19 16:23:01	4	16	177	0	160	201	0	81.80	29	12.84	CHANGED	VtE.apCLYTsplppKpKpWpDGhL+aa..phNs+l.Lasp.ssshlsstahppp.......p.hs.spEhcl.p.thLlpl...s-hhpphpp-ls	............c.apsLYT.cph.p+.Kp.KpW.p.DGhL+hp....phsp+hhLY..D-...pushlsshahpst..............................ttlpsGc-h.chpp..hLlpl...p-hht......................................................................	0	43	78	124
+10215	PF10383	Clr2		Transcription-silencing protein Clr2   	Wood V, Coggill P	anon	Wood V	Family	Clr2 is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast. Clr2 does not have any obvious well-conserved domains but, along with the other core proteins, binds to the histone deacetylase Clr3, and on its own might also have a role in chromatin organisation at the cnt domain, the site of kinetochore assembly.	25.00	25.00	26.10	27.80	24.30	24.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.93	0.71	-4.18	13	79	2009-01-15 18:05:59	2007-09-19 16:32:14	4	4	73	0	63	83	0	132.90	27	19.30	CHANGED	lappGIFlGAEhLhVGDsVRL...........tsh.ht.t...psstssssDVMVI-....EIplclhpsssshpu.......pVRlsGclYTsscppA.h..p.sshs..sspP........hsh-EVhsphp.hlGMuuhucW.............apLhs.s........sslclopshVlGRhYE	....ahpGlFlGAEhlhlGDsVRL.............hsht..p.s...............ssts..pss-lhlIc....pIphchhs.sssshts..........slplhGclYshs.ppu.tt....s.....spP..................hh.cElhpphp.hl.....shtthupW............................athht.t.............psspls.splhGRhY......................................................	0	14	32	50
+10216	PF10384	Scm3		Centromere protein Scm3	Mistry J, Wood V	anon	Pfam-B_19394 (release 21.0)	Family	Scm3 is a centromere protein that has been shown in Saccharomyces cerevisiae to be required for G2/M progression and Cse4 localisation [1].  The C terminal region of Scm3 proteins is variable in size and sometimes consists of DNA binding motifs [2].	24.30	24.30	24.30	25.90	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.78	0.72	-4.48	35	154	2009-09-14 14:05:34	2007-09-19 17:11:47	4	9	141	3	104	165	0	57.60	34	9.22	CHANGED	pcltpt+ppucp+hKstacsIh-KYup.-.cs.uDEIDL...pTGc...IVhDNGHL+slpscp	............cltpt+ptucp+h+stappIh-KYsp....-s.u.DEIDL...pTGp...IlhDNGHlcphpsp.t..............	0	25	51	80
+10217	PF10385	RNA_pol_Rpb2_45		RNA polymerase beta subunit external 1 domain	Coggill PC	anon	Gene3D, pdb_2a6h	Domain	RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.04	0.72	-4.17	149	8806	2009-09-11 00:06:38	2007-09-21 14:13:17	4	34	7040	41	964	6923	2365	66.20	46	8.12	CHANGED	YR+V.....ps.............GpV...oc-lhYLoA.-EcpahIAQAss..sl..........-ccG.phh....s.-hVhsR.hpu..-h...hhssspcV-ahDVS	.....................YR+V......ts........................GhV....TDE.l..pYLoA.EEs.palIAQANu..sL..........D.-.c.G....pFs..........-.-hVssR..ppG.......Es................thhs...-cVDYMDVS...........	1	338	646	822
+10218	PF10386	DUF2441		Protein of unknown function (DUF2441)	Finn RD, Coggill PC	anon	Gene3D, pdb_2aua	Family	This is a family of highly conserved, predicted, proteins from Bacillus species. The structure forms a homo-dimer. The function is unknown.	25.00	25.00	25.00	26.60	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.70	0.71	-4.15	2	90	2009-01-15 18:05:59	2007-09-26 11:48:52	4	1	90	2	4	56	0	137.10	76	70.61	CHANGED	NTLaHFFFEREpLNusGcDuhQILpcHYpNpELHIpNENApVVMsYMDQTIRAhRETIVEMlRLQEaPpYPSRLSCLYAAKSYEDALKWKALFDSYNREVLQIVKLpVIGsSFEGDGNLLPKEDuIPFSQKhEQAREYWKG	.....................................NTLYHFFFE+EQLNusGEDuhpIlppHYKN-ELHINNENApVVMNYMDQTIRAlRETIVEMVRLQEaP-YPSRLSCLYAAKSYEDALKWKALFDSYNREVLQIVKLRVIGsS.FEGDGN.LLPKEDGI...PFSQKhE..QAREYWKG....	0	2	3	3
+10219	PF10387	DUF2442		Protein of unknown function (DUF2442)	Finn RD, Coggill PC, Bateman A	anon	Gene3D, pdb_2auw & Pfam-B_2245 (release 23.0)	Domain	This family of bacterial and fungal proteins has several members annotated as being putative molybdopterin-guanine dinucleotide biosynthesis protein A; however this could not be verified. Hence the function is not known.  This family also includes the DUF3532 that was found to be related and was merged into this family. Members of this family also fall into the NE0471 N-terminal domain-like superfamily, a family of proteins with a unique fold in SCOP:143880.	21.10	21.10	21.20	21.40	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.66	0.72	-3.96	153	848	2009-01-15 18:05:59	2007-09-26 12:29:25	4	11	504	5	290	765	94	71.90	20	66.29	CHANGED	shsVphtss.....plhlphsD....Gcphtlsls.h...hppushppl..........pphplt.tstulpWs........shD.DluscuLhtstts	.................hpVphhpsh.plhlphs-....Gpphhhshp.hh......ppsshppL.........h...ppspl...p.st..slpWs..............s.s.hDlsspsLht....t.................	0	92	202	258
+10220	PF10388	YkuI_C		EAL-domain associated signalling protein domain	Finn RD, Coggill PC	anon	Gene3D, pdb_2bas	Domain	In Bacillus species this highly conserved region of the YkuI protein lies immediately downstream of the EAL (diguanylate cyclase/phosphodiesterase domain 2) Pfam:PF00563 domain so that together they form a monomer which dimerises for its enzymatic action. The region contains three alpha helices and five beta strands and is the C-terminal half of the structure.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.13	0.71	-4.57	14	277	2012-10-01 23:40:40	2007-09-26 14:17:17	4	6	265	6	64	194	4	149.80	31	33.45	CHANGED	hl-cshhK-+Lpp-hcpFIpaE+KKLps.aphsEphppclpph.lsclK+spp.s.Ehlhpluptls-hsFRlYlCDc-GaQhosNhhK.psGpWhlps-ahtKNWSWRPYFLENIh+Mppcp+G..llSDLYoDIETGEhIRTaSYPls-phYLFlDlsYpaLaEp-uLh	......................................................................................hptaht.chpphtt.hph.tp.h.ppltph.lt....p.cpst.p......s..p....hl.....t.....h.sp.t.l..s......ps..s..h..R..IahssccGhQpoGNs..h+.....p......s.....upW.....hlp....s..paht+NWSWRPY..FlcsIh..c.h.+..pp+s..hlS-hYtDlpTsch....hhThS..hs...l...s..s.p.hLhl...Dl..............................................	0	24	43	52
+10221	PF10389	CoatB		Bacteriophage coat protein B 	Finn RD, Coggill PC	anon	Gene3D pdb_2ifo	Family	CoatB is a single filamentous bacteriophage alpha helix of approximately 44 residues. It is likely to assemble into a complex of 35 monomers in a Catherine-wheel like formation [1]. It is the major coat protein of the virion.	24.80	24.80	25.50	25.90	24.10	24.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.13	0.72	-4.10	6	39	2012-10-01 20:22:05	2007-09-26 17:16:45	4	1	34	1	11	37	4	46.50	34	62.44	CHANGED	AuuuGlDVu-VssAIpuAtusIuoIGuuVLsVlVul+VaKWlRRuh	.............usutuhDlssVsoulsuAtssluslGuAVLslhluItlaKalR+Ah..	0	1	4	9
+10222	PF10390	ELL		RNA polymerase II elongation factor ELL  	Wood V, Coggill P	anon	Wood V	Family	ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF [1]. Some members carry an Occludin domain Pfam:PF07303 just downstream. There is no S. cerevisiae member.	21.60	21.60	23.80	23.80	21.50	19.90	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.86	0.70	-5.18	19	307	2009-01-15 18:05:59	2007-09-27 14:12:00	4	7	103	2	164	239	0	244.00	31	44.81	CHANGED	pEstsYGLshuphsss..pholhaVKLT-oAl+AlppaQp.....p...sh+PsIpF.pGspG.................................................................hlpIPpsc.sss...................hppFsFhlSslup-sspG.SaDClpQhhtpsGsspLpsLGsIp-KlslpAosDSYpt....oRpphspsEE-p+s+soh.IKsssp.su++Vph..+ps...................................................................................ssshssssP...ppcpopPh...............................................................................p.sssh+pts............ssssppRshR-RllHLLAL+PY+KsEllhRLp+DGlspp-+psLsslLppVusls.p-ssasL+chhap-lQ.cDWPsYoEs-+phlcphLs+pLs	.........................................................................................................................................................................................................................................................................................................................p.......................phh.l+Ls-sshpshpthpt...............ps.ItF..pG.pG.................................................................hlplPtss....sp...............................p.FsFhlSsh.sp-tspG.oh-....s..lpQh....stpGttpLpsLGslp-+l.slpA..s.sDSYph.......s+pphspsEE-.p+..spss...h..IK..sss...h....s.c.psph...pp.s..........................................................................................ths..ssss...ppppspPh.......................................................................................................................................p.t.thpptt..............................sslppRshR.-RllHLLAL+sa..+K.s.ELlh.R..L.p+.-G....l..s.p..-+stlss...hLppV.uphs...t....ct........oa...sL+c.hap-lp.cDWPhYo.-.-pp.lcphh.p...t.........................................................................................................................................................................	0	38	49	91
+10223	PF10391	DNA_pol_lambd_f		Fingers domain of DNA polymerase lambda	Finn RD, Coggill PC	anon	Gene3D, pdb_2bcq	Domain	DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [1].	29.80	29.80	29.80	29.80	29.70	29.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.32	0.72	-4.41	58	544	2012-10-03 02:11:09	2007-09-27 16:59:55	4	29	240	212	323	547	116	52.00	38	9.68	CHANGED	lphFsslaGlGspsApcaap.pGhRTL-DL...cp.pt.pLoptQplGlcaY-Dhpp	......hphFsslaGlG...spoApcaap..pGhRoL-...Dl.............+p....ps..pL..opp..QplGlcaY-Dht........	0	92	151	228
+10224	PF10392	COG5		Golgi transport complex subunit 5	Wood V, Coggill PC	anon	Pfam-B_24958 (release 21.0)	Family	The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.	29.00	29.00	29.10	29.30	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.38	0.71	-4.19	16	280	2012-10-03 17:31:52	2007-10-01 16:23:45	4	6	245	0	199	280	3	126.10	26	20.85	CHANGED	-sFL-ssFsspsFuNslLh.............tspstssssLDlsoslc+lpaDlpElDp+lcphhssst.pLLsphsshpptpu.llsplcsslptLstSacRLcscVlpPaccAtplpssLp+lapTscLLRsshhaltLuppL	........................sFL.sssFssppassphlt.........................................................thslus.Ls+Lthslppl-pclcp.lsspttsL.Lspssshpphps.llptlpsplpsLptuhcRLcpcll-PapphpphpttLp+lptsscLLRpshRhLtLu++L.........	0	63	110	164
+10225	PF10393	Matrilin_ccoil		Trimeric coiled-coil oligomerisation domain of matrilin	Finn RD, Coggill PC	anon	Gene3D, pdb_1aq5	Domain	This short domain is a coiled coil structure and has a single cysteine residue at the start which is likely to form a di-sulfide bridge with a corresponding cysteine in an upstream EGF (Pfam:PF00008) domain thereby spanning a VWA (Pfam:PF00092) domain. All three domains can be associated together as in the cartilage matrix protein matrilin, where this domain is likely to be responsible for oligomerisation [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.09	0.72	-4.59	14	256	2009-01-15 18:05:59	2007-10-02 16:16:30	4	52	50	3	93	230	0	44.00	40	7.85	CHANGED	pls.pEDsCtCEulltFQppVpstlppLspKL-sVo+RLptLEp+lh	...........cDsCtCEulltFQspspu.tlp...p..LT.p....+.......L...tt...hopRlp.LEspl........	1	5	12	33
+10226	PF10394	Hat1_N		Histone acetyl transferase HAT1 N-terminus	Finn RD, Coggil PC	anon	Gene3D, pdb_1bob	Domain	This domain is the N-terminal half of the structure of histone acetyl transferase HAT1. It is often found in association with the C-terminal part of the GNAT Acetyltransf_1 (Pfam:PF00583) domain. It seems to be motifs C and D of the structure. Histone acetyltransferases (HATs) catalyse the transfer of an acetyl group from acetyl-CoA to the lysine E-amino groups on the N-terminal tails of histones. HATs are involved in transcription since histones tend to be hyper-acetylated in actively transcribed regions of chromatin, whereas in transcriptionally silent regions histones are hypo-acetylated [1].	21.40	21.40	21.60	21.70	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.45	0.71	-4.17	45	314	2009-01-15 18:05:59	2007-10-02 16:40:42	4	9	267	3	220	310	2	156.60	28	35.93	CHANGED	sssuN-AlplplV..............................p....sstphp..t.......ss.FpPpFTa.IFG-sE..pIFGYcsLpIpLhasusohcsalplpYspK.......sshphsD....lpppLtc..hlPp......................s.hhpscp.....-Fhpsl..pp......................cpcs.ac.PsGp..hl.csa.......................s..ss....tp...ac......................................................................Iapsslts.ss...hpch+pRlQhFlhhFIE	........................ssuN-AlplpLV......................................p.........sspshtpt.............tsFpPpaoaplFG-sE..pIFGY+s..LpIpLhasAsshpshlplp........YspK......th..sshpssD....lpsplpp..hlPt...............................s..hhpsts.....-Fhptl....c..........................................cpts...Fp..P...Gp..ll..csa...................................s..ss......tp.............ap................................................................................Ia+s..shs..s...sshpchapRlQhFlhhFIE...........................................................	0	74	119	183
+10227	PF10395	Utp8		Utp8 family	Mistry J, Wood V	anon	Pfam-B_24590 (release 22.0)	Family	Utp8 is an essential component of the nuclear tRNA export machinery in Saccharomyces cerevisiae.  It is a tRNA binding protein that acts at a step between tRNA maturation /aminoacylation, and translocation of the tRNA across the nuclear pore complex [1].	21.00	21.00	21.40	21.60	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.20	0.70	-6.22	10	40	2009-01-15 18:05:59	2007-10-03 11:45:37	4	2	40	0	29	41	0	652.60	33	98.20	CHANGED	MPSlopPFhLusLP+luSLsshcptsssspsus.s.p.cssplslGIStSoISpYlIsPTPKLlasaPlPsTsIVsuhsVhshss..............................ppclashGLosp+Kp+hLplppc...................stsssussEssspacl.Klcc+llslKlh..scsplIlVlhcsGhlchaca...............pLpht+sh..cl.Yo..pFVpchc.pstp-allllss.pscK..lsYKLlpL....sscssulhEL.sSsIlEshslssophsYphGpLYpL..ssscIplYolPsh.plppoIplP.hlscp....-hlSlpslusNRVLLossNKIYLlDlhasulLsph-.....op.pshQlLhsuVlsspspupso+.ThAlslshKNGsN.sotLcVINIsVGosoLc-.uLGKShppsss.....ppsthLcsLFs-csh...........spsElsslphhclLp-Lp..pppclpp............FDsIhhphLK.cK..........................Ea.sEsDRhl.DspFlsplL-LIFs.......pFtss-..a....P.+oLhYLLTHPLFPhs+T+GLLsphc..spscLhKQAIVTCPNLPLc-LLppLFo.pNsE.lhhDlshRlLp-ao+c-IppshK+L.....uplDlpshlshllpssss............phapLlsllIDusGLFuh-t-sl-cLsuhI-scVplhspNsphlsLl-phhLpspstspsupppps.....................................ccsspslstp...YoVEhL-l	.....................................................PsLopsatlssLP+lssLs..ph.ss.....h.sus...p.sospIslGlStS.ISpYIlpPTPKLlasaslssTslVsshslhphps................................chashGLpspKp.phL.ltpp.....................st..ssssphhsphcl.K...h.cs+lhslKh....tpsphlhslhpNGhlphaca..................plphhpsh..clsYs..palpphp......t.tpcalhllss..pss+..lsa+Llpl......pssslhEl.sp.hhcshshpsuphsYp..GpLYpL.....spt..pI.haSlPph.plppsIpls.hlsc....pcllShpslusNRlLLossNpIYLLslhasSlLophc........ho+s+shplLpssVlss....c.pS.p..so+.ThAlslshKNtsN.sopLclINlDVGoNs.Lp-.uLGKShp.....ssss...............sps.lLcsLFs-cshs..........tss-lt.pl...chlccLp..pspDlsp............F-sIhhthLK.+c..........................Ea.s-pDRhl.D.sFlspVlcLIFs.......pFp.ss-...a......P.+TLTaLLTHPLFPhphTcsLLphLc..spPRLhKQAIVTCPNLPlp-LLppLhs......lcNpE.......l...hhDlshRllp-Fop-pIppphKcL..................splDlpshIphllshsps............phapLLslllDuhGL...Fs.h....ctshlcpLsphI-ppVchhppNophhsLl-pthhpp.thtpppscppss.....................................ppps.........hYolEhL-l...................................................................................................	0	5	16	27
+10228	PF10396	TrmE_N		GTP-binding protein TrmE N-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1xzp	Family	This family represents the shorter, B, chain of the homo-dimeric structure which is a guanine nucleotide-binding protein that binds and hydrolyses GTP.  TrmE is homologous to the tetrahydrofolate-binding domain of N,N-dimethylglycine oxidase and indeed binds formyl-tetrahydrofolate. TrmE actively participates in the formylation reaction of uridine and regulates the ensuing hydrogenation reaction of a Schiff's base intermediate.  This B chain is the N-terminal portion of the protein consisting of five beta-strands and three alpha helices and is necessary for mediating dimer formation within the protein [1].	21.60	21.60	21.60	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.38	0.71	-4.11	270	4354	2012-10-01 23:12:28	2007-10-03 14:31:21	4	10	4206	9	1027	3258	2398	116.40	44	25.73	CHANGED	TIsAlATs..sG.pGuluIlRlS.....Gspuhplspp...lh.............sp.....t.p.........s...+pspa...s..plhD....ts.........sp.......hlD-s.l.llhFhuP........pSFTGEDVlElpsHGGhsllptlLp.tllph..............G..............sRhAcPGEFTcRAFLNG+	..........................................TIsAluTs...G...cGuluIlRlS.....Gs..p.A...h.p.l...u.pplh...........................sc.....p...............s..+phpY..s...plhD............ts....................................sp.................llD..c.s..l...lhh.ah.u..P.........pSF.TG..EDllElpsHGG.lllstlLphllph...............G...............................................sRhA..cPGEFTcR.....AFLNG+.......................	0	354	652	860
+10229	PF10397	ADSL_C		Adenylosuccinate lyase C-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1c3c	Domain	This is the C-terminal seven alpha helices of the structure whose full length represents the enzyme adenylosuccinate lyase. This sequence lies C-terminal to the conserved motif necessary for beta-elimination reactions [1], Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole-carboxamide ribotide into aminoimidazole-carboxamide ribotide, the eighth step of the de novo pathway, and the formation of adenosine monophosphate (AMP) from adenylosuccinate, the second step in the conversion of inosine monophosphate into AMP [2].	22.90	22.90	22.90	22.90	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.43	0.72	-3.97	148	3649	2009-01-15 18:05:59	2007-10-03 14:33:22	4	11	3192	22	1012	2751	1563	82.20	29	18.48	CHANGED	tGllhopplhhsLs.p.pGluRppAaclVpcsuhpuhp......p.sps.........ht....-hLt...pDsplt...thlopc-.l.cplh.DPptalspssplhc+lh	..................................GLlhop+VhhsLl..c..pG.......hsRE.cAa-lVptpuhpuhc.......................................p..pss............hh....phLt.....sD.scls.......t.h.Lo.p......--.l..c.chh.....Dsp.haht....pssslhcRh..................................	0	333	643	850
+10230	PF10398	DUF2443		Protein of unknown function (DUF2443)	Finn RD, Coggill PC	anon	Gene3D, pdb_1zke	Family	This is a small family of highly conserved proteins from bacteria, in particular Helicobacter species, The structure is a bundle of alpha helices. The function is not known.	25.00	25.00	31.70	51.50	22.30	21.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.61	0.72	-4.18	3	57	2009-01-15 18:05:59	2007-10-03 16:39:50	4	1	56	6	5	26	0	77.80	81	99.60	CHANGED	MFEKIDcIL+sIEDSR-EIEILLNlAKISLlDYIMIKRGSMDMPEHLshshLsQIDEEVEKLKEpI-ALNKIKKELLlF	MFEKIRKILA-IEDSQNEIEMLLKLANLSLGDFIEIKRGSMDMPKGVNEAFFTQLSEEVERLKELINALNKIKKGLLVF.....	0	2	4	5
+10231	PF10399	UCR_Fe-S_N		Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal	Finn RD, Coggill PC, Bateman A	anon	Gene3D, pdb_1zrt	Motif	This is the N-terminal region of the E or R chain, Ubiquitinol-cytochrome C reductase Fe-S subunit, of the hetero-hexameric cytochrome bc1 complex. This region is a TAT-signal region. The cytochrome bc1 complex is an oligomeric membrane protein complex that is a component of respiratory and photosynthetic electron transfer chains.\	  The enzyme couples the transfer of electrons from ubiquinol to cytochrome c with the the generation of a protein gradient across the membrane [1]. The motif is also associated with Rieske (Pfam:PF00355), UCR_TM (Pfam:PF02921) and Ubiq-Cytc-red_N (Pfam:PF09165).	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.99	0.72	-4.79	49	936	2012-10-02 00:19:25	2007-10-03 17:10:36	4	4	874	26	297	706	1269	39.70	41	20.61	CHANGED	hssspsspsoRRDFLalATuusuuVGuuussWPhIsQMNPs	...........ppshsssRRcFLhhA.TussGuVGususAh.PFlsShsPS........	0	73	167	224
+10232	PF10400	Vir_act_alpha_C		Virulence activator alpha C-term	Finn RD, Coggill PC	anon	Gene3D, pdb_1yg2	Family	This structure is homo-dimeric, and the domain here is the C-terminal half of the structure, often associated with PadR upstream, (Pfam:PF03551), which is a transcriptional regulator.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.74	0.72	-3.62	37	838	2009-09-11 09:27:19	2007-10-03 17:40:19	4	3	630	1	235	647	7	88.30	21	48.18	CHANGED	sslR-EhLlKlhusshhssssltsplpcphphppp+LspYcclc.pchhss...tpth.stpphhpaLsLctGlphEpthlcWs-cslthLsthp	............hRD-hhlKlhhs...sh.hs.s.sshht.lp...cphpt...ppcplpp.app...hc..pphass..............tt...sppphhphLsLct..ulthcpshlpWh-cslttLp...t.................................................	0	73	158	207
+10233	PF10401	IRF-3		Interferon-regulatory factor 3	Finn RD, Coggill PC	anon	Gene3D, pdb_1zoq	Family	This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein.  These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).\	  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.	20.80	20.80	20.80	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.92	0.71	-4.70	43	649	2012-10-01 21:55:46	2007-10-04 10:54:49	4	8	78	11	242	858	0	168.80	31	40.48	CHANGED	hspLclshaYpGchVt.phplssspGsRlhh....tsssststhht.............shpplhFPssst..l.....sppQpphsccLLssl-+GllLphssp.ulaupRLsps+VaWsusss.tss.....tPs.pLc+s.ppsplFshppFlp........................-Ltpa.p.pstssPp.a.plhLCFG-chss...pstpc+LIhVpl.PhhsRhlhEhsp	..............................................hpLcl.ph.hY+Gc..Vt..phslsssp.GCRlhh............tss.stst...s.................shppVt..F..Psspt...l............sp....pQ....pp....hspcLL.stl-+GllLthssp...u......la.u.pRL..Cps+VaWsuspsssts..........tPs...hlpRp.ppsclFshp.p.Flp.........................-Lhta...p.....pttt......P....p.....a.plhLCFGE-aPs.t.pshp++LIhV.pl..shhs+.lhp.h...........................................................................	0	25	43	115
+10235	PF10403	BHD_1		Rad4 beta-hairpin domain 1	Bateman A	anon	Bateman A	Domain	This short domain is found in the Rad4 protein. This domain binds to DNA [1].	20.60	20.60	20.60	21.60	20.50	17.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.81	0.72	-4.45	56	421	2009-01-15 18:05:59	2007-10-05 13:00:34	4	18	274	3	311	451	1	57.10	35	6.66	CHANGED	phscshPcol...........pshKsHPhalL-+pL++pEslhP..sspslGhhps.t...................EsVYtRssVh	.....h..pcshPpsl...........psaK..sHPl........YsLcRaLp+pEslhP...ssp....lGhhps.....................EsVYpRssV.......................	0	91	161	258
+10236	PF10404	BHD_2		Rad4 beta-hairpin domain 2	Bateman A	anon	Bateman A	Domain	This short domain is found in the Rad4 protein. This domain binds to DNA [1].	21.30	21.30	21.40	22.70	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-9.27	0.72	-3.66	62	397	2009-01-15 18:05:59	2007-10-05 13:01:31	4	16	257	3	291	426	3	61.20	34	7.04	CHANGED	L+St-pWh+p..GRslKhsEp.Ph...KhVpt.t.......p........p.tpp...............................phsLYuhaQT.......-.ahPP	......l+St-sWh+p..GR.sl+..hGE.....p..Ph...KhVpt.pst.....ttp.........pttppt.............................................................thsLYuhaQT.......-.YhPP.............	0	80	150	241
+10237	PF10405	BHD_3		Rad4 beta-hairpin domain 3	Bateman A	anon	Bateman A	Domain	This short domain is found in the Rad4 protein. This domain binds to DNA [1].	20.60	20.60	20.70	22.90	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.52	0.72	-4.27	34	411	2009-01-15 18:05:59	2007-10-05 13:03:48	4	17	264	3	308	438	6	76.00	38	8.82	CHANGED	lP+NsaGNl-latssMlPhGsVHlp......hsslt+lA+...........tLsIDaA.AVTGFcF......+stpspPVhsGlVVscEap-tlhpsa	....lP+NpaGNl-l..a..hss.MlPtGsVHlp............................hss...ht+lA+..............................pL.sID..aApAVsGF-F...............+sttu..hPlhpGlVVscEhc-hlhpsh................	0	91	162	258
+10238	PF10406	TAF8_C		Transcription factor TFIID complex subunit 8 C-term 	Wood V, Coggill P	anon	Wood V	Domain	This is the C-terminal, Delta, part of the TAF8 protein [1]. The N-terminal is generally the histone fold domain, Bromo_TP (Pfam:PF07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery [2].	19.10	19.10	19.70	19.30	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.42	0.72	-3.91	25	316	2009-01-15 18:05:59	2007-10-08 10:18:23	4	7	242	0	219	302	0	49.80	39	13.82	CHANGED	sYIPsa..LPsFPscHTYppTPhappslo.D.+plRc+hsc-uRhsE+uLh+Lh	.........aIPsa..hPsFPssHTYhp.TPha..p..c.ho.....DhptlR..c....+tspppRpsEcALp+h............................	0	60	110	174
+10239	PF10407	Cytokin_check_N		Cdc14 phosphatase binding protein N-terminus   	Wood V, Coggill P	anon	Wood V, Pfam-B_23062 (release 22.0)	Family	Cytokinesis in yeasts involves a family of proteins whose essential function is to bind Cdc14-family phosphatase and prevent this from being sequestered and inhibited in the nucleolus. This is the highly conserved N-terminus of a family of proteins which act as cytokinesis checkpoint controls by allowing cells to cope with cytokinesis defects. These proteins are required for rDNA silencing and mini-chromosome maintenance [1].	21.20	21.20	21.20	21.90	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.35	0.72	-4.36	16	70	2009-09-11 05:31:51	2007-10-08 14:49:30	4	2	54	0	49	73	0	73.10	37	7.39	CHANGED	ppsKKFLah.TcsssoLhpLs-EIhs+hpKlYPs.p..clcIhoLQDpstCDLDP-FlVcDVFs.ssshVRVILcsch	..........s.h+KFLah.Tcs.ssoLhpLupEIls+acKlYPshp...sl-.IloLQDp..s..u..CDLDs-FlVcDVFs.ssshl+Vllcs-.h...............	0	15	29	44
+10240	PF10408	Ufd2P_core		Ubiquitin elongating factor core	Wood V, Coggill PC	anon	Wood V, Pfam-B_4085 (release 22.0)	Family	This is the most conserved part of the core region of Ufd2P ubiquitin elongating factor or E4, running from helix alpha-11 to alpha-38. It consists of 31 helices of variable length connected by loops of variable size forming a compact unit; the helical packing pattern of the compact unit consists of five structural repeats that resemble tandem Armadillo (ARM) repeats. This domain is involved in ubiquitination as it binds Cdc48p and escorts ubiquitinated proteins from Cdc48p to the proteasome for degradation. The core is structurally similar to the nuclear transporter protein importin-alpha. The core is associated with the U-box at the C-terminus, Pfam:PF04564, which has ligase activity.	20.40	20.40	21.50	21.20	19.40	20.10	hmmbuild  -o /dev/null HMM SEED	629	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-12.77	0.70	-6.28	50	532	2009-01-15 18:05:59	2007-10-09 16:35:59	4	19	290	5	355	518	10	538.70	29	57.82	CHANGED	LGslhslSshs............sphspta......h..tsstptsppplpsthpslptphpshhppLapllppll+suspsR..pphLpahupl..lphNptRpph..........................phc.ppluS..-GFhhNlshlLl+LspPhhc............hsKlc+IDssY..................................hhp..sshlcl.......p-ETclpus.ccscphhspptp..............................................pFlo-hFFLThpshahGhtshhpchpcltpplpchpcphpphptp...............p..htphppplcthhspphshcsh.lhcsshhppshpFhshsstalh+lh...........s.tp.hsp.pthphP......h.tt.........................................................................s.........................aphlPEahl-slhsah...hahhph.......sshhhst.phcphlphslhhhpssp.hlcNPaL+u+llclLhhhh.sht..tppthh.s........lhpsppls.....pcpLlhuLlchYl-lEpTGsp....sQFY-KFNhRapIstlhcplW.ppsta+p.pltc.scs...........................................................................s.s.hFlRFlshllNDssa.LLDEulspLpcI+ch..ppphpstsphtsh......................................sppp...cpc....................................................pppplpptcpps+ohhtLupcolphhphhT..pplscsFh.psEll-RlAuMLNYsLptLsGPKsps.L.KV+ssccYs..FcP+plLsplsclYlNLs..........ppcp...FltAVupDGRSas.phFpcAhpllpchs.lhstp.lpphpphspclcc	............................................................LGshhp.hSsh.................stsspta...............a......ss.t.s.tph.ts.ttslp.hhp.hppplhplh.ppl..l....hs...sp...sR....pthLp.ahuth..lphNttRtth..........................php.p...h..huo....DuFhhNlhhlL.pLsp.h.................KltplcspY...................................hp..pttlph........pcETpl.ss.pt.p.thhtp...t...................................................pF.o-sFaLThtshahuhhs..hhpp....h..p.h..pplcchppt.hpphptpt..............................p.hhpphcpphcthhp.hhsh..csh..l.......h-...ph.ppshp.Fht.hhh.hll.plh.....................t............thphP...............Ls.t.............................................................................................................s...t.hthlP.Eahl-slsphh...hFlhph......................s..hh....t..t...hpp.hlthhlh.hhts.p....hl+NPaL+A+L.splL..hh...ht......pt.hh.p................................hhppp.hs.......tp.Lh.uL..hcha.s.-lEhTGsp..............spF..h-KFshRh.l..lhc.lW..ts..a+t..phhp.spp..........................t.....Fl+FlNhLhNDsha.LLDEu.....l.ptLtcI+ph..Qt.hpsp.tphtth......................................................................s.pt.....ppp.............................................................................cpppLtp.tp.s+.hhhLup-TlshhphhT..p..p..l..tpsFh..tPpls.p...........RluuMLNa.LppLsGPKpts.L.KVc..s...............p.cYs..FcP+pLlsplsslYlpL....................................sppp.........FhtAlupDtRSY..s.plFppshphlp.+h...s...h.....sst.l.tpaptlsp+hp..........................................................	0	132	197	291
+10241	PF10409	PTEN_C2		C2 domain of PTEN tumour-suppressor protein	Finn RD, Coggill PC	anon	Gene3D, pdb_1d5r	Family	This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding.  This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam:PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane [1].	25.50	25.50	25.50	25.80	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.88	0.71	-4.44	61	847	2012-10-10 12:23:49	2007-10-11 15:54:09	4	39	146	25	477	790	5	136.70	24	15.32	CHANGED	hsspslhlpplhl......psl...........P.h....p.ts.....ss.........cPhlplhptpphl.................t.phpthppt.............ptpphhhhhs.sl..l.p..GDlhlch.hppp........hhtcph.....hFphhFNTuFlp...................................................................................................................................sshLhhs+s-LDt.stcs...cpaspsFpVclhFsc	.............................................................................................psLhl+plhh.psl...........P.F...ptts................uC.............................cPhh.clh..ttpphl..............................................pst..hph.ht.ph....................................................................ptphhhh..h...h...s.....sl...hl.p...G....Dlh.lch.aHtp..p.........thpcph.............hFph.FpTsFlp.................................................................................................................................................................................................................sthLhhsKp-LDt.spc.....s.......cpasptFpVclhFt..................................................................................................	0	147	223	334
+10242	PF10410	DnaB_bind		DnaB-helicase binding domain of primase	Finn RD, Coggill PC	anon	Gene3D, pdb_1dd9	Domain	This domain is the C-terminal region three-helical domain of primase [1]. Primases synthesise short RNA strands on single-stranded DNA templates, thereby generating the hybrid duplexes required for the initiation of synthesis by DNA polymerases.  Primases are recruited to single-stranded DNA by helicases, and this domain is the region of the primase which binds DnaB-helicase [2]. It is associated with the Toprim domain (Pfam:PF01751) which is the central catalytic core.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.22	0.72	-3.98	185	3150	2009-01-15 18:05:59	2007-10-11 16:20:54	4	23	3048	9	677	2386	736	58.20	24	9.81	CHANGED	lh-Fhhcphtp..p.....h.sl..sss-u+sphlpp.shsllspls.sssh+phhhpcLucthulstppl	................L.pFhhpplht..p......h.sL...sss-G+sphhpt.shsllspls.stsh.RphhhppLupclGl..pt............................	0	208	432	568
+10243	PF10411	DsbC_N		Disulfide bond isomerase protein N-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1eej	Domain	This is the N-terminal domain of the disulfide bond isomerase DsbC. The whole molecule is V-shaped, where each arm is a DsbC monomer of two domains linked by a hinge; and the N-termini of each monomer join to form the dimer interface at the base of the V, so are vital for dimerisation [1]. DsbC is required for disulfide bond formation and functions as a disulfide bond isomerase during oxidative protein-folding in bacterial periplasm. It also has chaperone activity [2].	21.00	21.00	21.10	21.20	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.57	0.72	-4.71	144	1562	2009-01-15 18:05:59	2007-10-12 11:30:55	4	5	1318	12	304	941	348	55.30	33	22.65	CHANGED	lp..ppLp......phh..shplp..slpsoP...lsG.LaEVhs..ss...s......llYsstcG.callt.Gplh..-hpspp	....................lppsLt......ch....sl.p.ss..sIpsoP...lsG...hhpVho...su....s.......llYsos..DG....+allp.G.s.la..Dlssp.t.......	0	60	159	243
+10244	PF10412	TrwB_AAD_bind		Type IV secretion-system coupling protein DNA-binding domain	Finn RD, Coggill PC	anon	Gene3D, pdb_1e9r	Domain	The plasmid conjugative coupling protein TrwB forms hexamers from six structurally very similar protomers [1]. This hexamer contains a central channel running from the cytosolic pole (made up by the AADs) to the membrane pole ending at the transmembrane pore shaped by 12 transmembrane helices, rendering an overall mushroom-like structure. The TrwB_AAD (all-alpha domain) domain appears to be the DNA-binding domain of the structure. TrwB, a basic integral inner-membrane nucleoside-triphosphate-binding protein, is the structural prototype for the type IV secretion system coupling proteins, a family of proteins essential for macromolecular transport between cells and export [2].	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.04	0.70	-5.84	37	675	2012-10-05 12:31:09	2007-10-12 13:00:04	4	14	429	36	140	6042	663	312.90	31	53.44	CHANGED	shpluulPh.shpsEtpHhhlsGosGoGKoshlpcllsphRtR........G-RAllaDhsGsFhppFac..........ssp.DllLNPhDsRsssWshasEsps.hDacshApullP..t..ssss-sFWspuARtlFspssh+L.tpp..spposppLhctlhssslcpLcphLtsT.usslhutp..sp+.sstSl+uslsshlcslphLsstt..........ssFSIR-Wlpssp......suhLFlosptsptssl+PLlohWlslAhpslhu..hst......spc..+R.lWahhDELsuLp+LssLtpsLscuRKaGGshVlGlQuhuQLcclYGpc.tApolhuhhsT+lhhpss..sscsAchhuc..lG..cpElcchpEshSaGtss.hRDGs...........ohsppcpt...c.lVhso-Ihs.LssLpu.....alphssshPls+lplp	.........................................................................................................................................................................................................................s...hsslsh....hp.t.E.......pp.h.hlhGos.GsGK..o..p..h..l..p....p..l...h....p.......h..h...p..+....................G..c..h..s...l..l..a..D..........p......s.....p.........a........h......p......p....a..a...p........................................t........D.....h.....l.....l........N...P...h.....D......t....R..........s.............t.....Ws.........a......p........-....h........h........p.........................-..........h..........p....p.......h..........u.p....sl...ls...............tst....tcsaW.tu......u....ct..lh........s.............p....h............h.....h.....h.h....t.....p...p.....................p..........t..........s..................t.........p........l............h...p.........h........h............h................t.........................p............h...........c..............p............l..........p....p.....h.....l........t........s.........o....................s...............t...........s.......h.........h.p....tp..................hp+.....s...s....h........S....l.....p.....u........s.......l....s..s...h.....l.......p......s.h...p.....h....ltt.......................................t.F.o....l...+....c...W....hps.t................tuhLF.l...o........p.....t.....p...p.....c....s.....s....l....p.P....l.l....u....h....h....l....s....h....s....h...p....t.l.hs........hs.................................sp...p.......p+.....l....a....h.h..h.DE.ls........o....L....t..+.........l......s..p....l........ph..l....s..p.uR.......caG.........ssh.l.hG.h.Qsh.s.Q..L.....c.....c.....h....Y....G..c.p...h.A....t....s....l...h.s....h.h...s.oph..h.h..p.ss.....s.t...p...hA.chhut....l.G.....c..p..-...h.......p...h.......p.....c...p....h......o.h....u....t..s...................t.s...u.s.........................sh.sp..p......ph........p....l..l.......sc.l..p.Lsshps.....alhhst....................................................................................................................................................................................	0	27	81	120
+10245	PF10413	Rhodopsin_N		Amino terminal of the G-protein receptor rhodopsin	Finn RD, Coggill PC	anon	Gene3D, pdb_1edx	Domain	Rhodopsin is the archetypal G-protein-coupled receptor. Such receptors participate in virtually all physiological processes, as signalling molecules. They utilise heterotrimeric guanosine triphosphate (GTP)-binding proteins to transduce extracellular signals to intracellular events.  Rhodopsin is important because of the pivotal role it plays in visual signal transduction. Rhodopsin is a dimeric transmembrane protein and its intradiskal surface consists of this amino terminal domain and three loops connecting six of the seven transmembrane helices. The N-terminus is a compact domain of alpha-helical regions with breaks and bends at proline residues outside the membrane [1]. The transmembrane part of rhodopsin is represented by 7tm_1 (Pfam:PF00001). The N-terminal domain is extracellular is and is necessary for successful dimerisation and molecular stability [2].	21.10	21.10	21.40	21.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.73	0.72	-4.28	17	2285	2009-01-15 18:05:59	2007-10-12 14:21:53	4	2	1603	37	51	1764	0	30.00	80	15.25	CHANGED	NGTEGsNFYlPMSN+TGlVRSPaEYPQYYLA-Paha	...............NFYlPMSN+TGVVRSP..FEYPQYYLA-PWpY...	0	1	10	28
+10246	PF10414	CysG_dimeriser		Sirohaem synthase dimerisation region	Finn RD, Coggill PC	anon	Gene3D, pdb_1pjq	Domain	Bacterial sulfur metabolism depends on the iron-containing porphinoid sirohaem. CysG, S-adenosyl-L-methionine (SAM)-dependent bis-methyltransferase, dehydrogenase and ferrochelatase, synthesises sirohaem from uroporphyrinogen III via reactions which encompass two branchpoint intermediates in tetrapyrrole biosynthesis, diverting flux first from protoporphyrin IX biosynthesis and then from cobalamin (vitamin B12) biosynthesis. CysG is a dimer of two structurally similar protomers held together asymmetrically through a number of salt-bridges across complementary residues in the CysG_dimeriser region to produce a series of active sites, accounting for CysG's multifunctionality, catalysing four diverse reactions: two SAM-dependent methylations, NAD+-dependent tetrapyrrole dehydrogenation and metal chelation. The CysG_dimeriser region holding the two protomers together is of 74 residues [1].	20.40	20.40	20.40	20.40	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.93	0.72	-4.49	132	1426	2009-01-15 18:05:59	2007-10-12 16:12:34	4	8	1263	6	269	987	131	59.40	36	13.80	CHANGED	tslGpLAshuuphRscV+pplsshstRRpFWEchh.pG.huptlhsGppppAcpthpptls	...........pLGplAchAuphRscVKpphs.shspRR+.FWE+hF.sspl..Aptltsscpptsppthcphl........................	0	54	139	201
+10247	PF10415	FumaraseC_C		Fumarase C C-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1fup	Domain	Fumarase C catalyses the stereo-specific interconversion of fumarate to L-malate as part of the Kreb's cycle. The full-length protein forms a tetramer with visible globular shape. FumaraseC_C is the C-terminal 65 residues referred to as domain 3. The core of the molecule consists of a bundle of 20 alpha-helices from the five-helix bundle of domain 2. The projections from the core of the tetramer are generated from domains 1 and 3 of each subunit [1]. FumaraseC_C does not appear to be part of either the active site or the activation site but is helical in structure forming a little bundle.	20.70	20.70	20.70	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.29	0.72	-3.90	258	5840	2009-01-15 18:05:59	2007-10-12 16:51:58	4	10	3710	79	1358	4033	1826	55.00	43	11.79	CHANGED	LVTALNPhIGY-pAAcIAKpAhcpGpol+-ssl.chGhl.......oc-phDcllcPppMspP	................lVTALNPaI.GY-pAAcIAKpAtc.pGpol+Essl.ch.Gh.L.........oc-chDchl.cPppMhtP.......................	0	415	827	1129
+10248	PF10416	IBD		Transcription-initiator DNA-binding domain IBD	Finn RD, Coggill PC	anon	Gene3D, pdb_1pp8	Domain	In Trichomonas vaginalis, thought to be the earliest extant eukaryote, the sole initiator element for control of the start of transcription is Inr, and this is recognised by the initiator binding protein IBP39. IBP39 contains an N-terminal Inr binding domain, IBD, connected via a flexible, proteolytically sensitive, linker (residues 127-145) to a C-terminal domain. The IBD structure reveals a winged-helix-wing conformation with each element binding to DNA, the central helix-turn-helix contributing the majority of the specificity-determining contacts with the Inr core motif TCAPy(T/A). The binding of IBP39 to the Inr directly recruits RNA polymerase II and in this way initiates transcription [1].	25.00	25.00	25.00	26.90	24.80	23.20	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.39	0.71	-4.34	94	107	2009-01-15 18:05:59	2007-10-12 17:53:28	4	2	1	7	107	109	0	122.10	22	48.18	CHANGED	ppD.pp.pahpLcphlss..p+pt+.............spphpsFsptLptlhpast+sss.p..RshlsGltWhsss...lslNscpLphLls+sKSo.....INGshpphGatth..t....tt.h...hs....hhps..shsph+.pWolRphss	...............D..pa.pLpphlss..p+pt+.............spphpsFsptLptlhpash+sss.p..RshlsGltWhsss...lslNscpLphLls+sKSo.....INGshpphGatth.tptp..tp.lhthhs.....htts..t.+.pWolR....s.....................................	0	107	107	107
+10249	PF10417	1-cysPrx_C		C-terminal domain of 1-Cys peroxiredoxin	Finn RD, Coggill PC	anon	Gene3D, pdb_1prx	Domain	This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [1]. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine, upstream of this domain; and glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulfide to the sulfhydryl and consequent activation of the enzyme [2].  The domain is associated with family AhpC-TSA, Pfam:PF00578, which carries the catalytic cysteine.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.89	0.72	-4.30	86	5521	2009-01-15 18:05:59	2007-10-15 10:44:00	4	14	3627	357	1733	3878	622	35.40	38	17.34	CHANGED	ALQhs-cp.s..ssPAsW.ps..........Gccsl...ssotc..u..hpcahps	.....AhQasppH..G-..VCPAsW.ct...........Gccsl...p.s.o.-............h......................	0	559	995	1407
+10250	PF10418	DHODB_Fe-S_bind		Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	Finn RD, Coggill PC	anon	Gene3D, pdb_1ep3	Domain	Lactococcus lactis is one of the few organisms with two dihydroorotate dehydrogenases, DHODs, A and B [1]. The B enzyme is a prototype for DHODs in Gram-positive bacteria that use NAD+ as the second substrate. DHODB is a hetero-tetramer composed of a central homodimer of PyrDB subunits resembling the DHODA structure and two PyrK subunits along with three different cofactors: FMN, FAD, and a [2Fe-2S] cluster. The [2Fe-2S] iron-sulfur cluster binds to this C-terminal domain of the PyrK subunit, which is at the interface between the flavin and NAD binding domains and contains three beta-strands. The four cysteine residues at the N-terminal part of this domain are the ones that bind, in pairs, to the iron-sulfur cluster. The conformation of the whole molecule means that the iron-sulfur cluster is localised in a well-ordered part of this domain close to the FAD binding site [2]. The FAD and and NAD binding domains are FAD_binding_6, Pfam:PF00970 and NAD_binding_1, Pfam:PF00175.	23.90	23.90	23.90	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.62	0.72	-4.46	180	2835	2012-10-02 17:47:23	2007-10-15 12:37:55	4	37	1790	3	745	2221	217	38.60	43	13.13	CHANGED	EphMsCGlGhChuCs..lpst..........hpl..CpDGPVFsspclt	.....EppMs.C.GhGtChuCt..lpsstt...................hhV..ChDGPVFssppl........	0	318	533	651
+10251	PF10419	TFIIIC_sub6	TFIIIC_subunit;	TFIIIC subunit	Mistry J, Wood V	anon	Pfam-B_14433 (release 21.0)	Family	This is a family of proteins subunits of TFIIIC [1].  TFIIIC in yeast and humans is required for transcription of tRNA and 5 S RNA genes by RNA polymerase III.  Yeast members of this family are fused to phosphoglycerate mutase domain.	20.80	20.80	21.10	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.25	0.72	-4.49	25	235	2009-11-13 15:40:22	2007-10-15 13:05:59	4	6	207	0	162	231	0	34.40	35	13.12	CHANGED	lplhGL-ocpPllplsspl.apGsWcchlGT-lhFs	....hpllGl-ocpPllplsspl.FpGpac.-slGTplhFp.....	1	46	78	128
+10252	PF10420	IL12p40_C		Cytokine interleukin-12p40 C-terminus	Finn RD, Coggill PC	anon	Gene3D, pdb_1f42	Domain	IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms [1]. This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40 [2]. The domain is often associated with family fn3, Pfam:PF00041.	25.00	25.00	30.30	29.20	21.20	22.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.07	0.72	-3.88	21	132	2009-01-15 18:05:59	2007-10-15 14:05:34	4	6	63	8	36	104	0	87.30	42	29.28	CHANGED	scsaLcCpApNYuG..cFpCuWhht..pssh.hhpl+upR.....................................sSsssptVoCuhs................pchulpCp.--stCPhAEEotPIplslcstpc	......KsFL+CEA+NYSG..cFTC.Whss.hsssl..pFsl+..usR.....................................sSsss...psVTCusssh..........ppp.pcYolpCQ.-cssCPhAEEshPIclsl-shp......................	0	1	6	15
+10253	PF10421	OAS1_C		2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus 	Finn RD, Coggill PC	anon	Gene3D, pdb_1px5	Domain	This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end [1]. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesise 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication [2]. This domain is often associated with NTP_transf_2 Pfam:PF01909.	19.90	19.90	19.90	22.40	19.00	19.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.44	0.71	-4.81	49	511	2009-01-15 18:05:59	2007-10-15 16:12:05	4	20	58	2	142	448	0	173.60	46	48.00	CHANGED	sscPs.splYspLIcpps..t..ptGEFSsCFTELQ+sFlcpRPsKLKsLIRLVKHWYppCpc+......htssLPPpYALELLTlYAWEpG.sspspFshApGFRTVL-L...ltcYppLCIYW....Th.YsFccphlppaLppQLc+sRPVILDPADPTsNVusu.sh.sWclLAcEAptWLppsChpststssVssWcV.sth	.................................s..pPs.splYspLIptts......ptGEFSsCFoELQ+sFlp.pR....P.sKLKsLIRLVKHWYppspcp................t....ssLPPpYAL.ELLTlYA...WEpG.st..pspF...shApGF.R.TVL.-L.........l.ppYppL.....CIYW.....Th.YsFcs.hlppaLppQLp.......+s.......RPlILDPADPTtNluts.s...WchLApEAtthh.ptsChhptptssltsWpV...h....................................	0	29	35	37
+10254	PF10422	LRS4		Monopolin complex subunit LRS4	Mistry J, Wood V	anon	Pfam-B_63451 (release 22.0)	Family	Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae, that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [1][3]. The orthologous complex in Schizosaccharomyces pombe is not required for meiosis I chromosome segregation, but is proposed to play a similar physiological role in clamping microtubule binding sites [2].  In S .cerevisiae this subunit is called LRS4, and in S. pombe it is known as Mde4.	21.70	21.70	21.70	24.00	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.88	0.70	-5.02	5	29	2009-01-15 18:05:59	2007-10-15 16:21:14	4	2	28	2	18	21	0	226.90	38	72.84	CHANGED	LQLlA-YYcSVL-sE+I...........YhEa..........sp.phpFhuspKTNAscs-.............sphlT-EsLpLQ+Q.......................IsQLssDLQlp+pEsE......................KL+clpKTQKAl......................LESKLpotKupVDphK.....cpossuscupsRssshuts-cppRupthppt+.o.........FHLLSP....IhsscpP.............................sSssupc+p...............uGLRplLcsGcsTIFDp.Sp..cD-.................................sDEDu-pssslpshphutsosR+.lsuL+sos-	................................................LQLLuNYYKuhl-uERI...........Y.EY..............psphphuu.s+hssspus.............sp+ls-ETLhLQRQ.......................lsQLsppLQ.hphpENE.........................................KL.hplQKsQKAL.................................................................hpSKLsopcthIDcLK.cLpspphsscpcspppssssups-pppsspttpss+so..........hH.LL..SP......lssRcps....t.....tsp...........................sSssupc+s...................pGLRplLooG+sTlFDs....Spp.DD-..................................s-sschppDssssp.t....................................................................................................	0	2	8	15
+10255	PF10423	AMNp_N		Bacterial AMP nucleoside phosphorylase N-terminus 	Finn RD, Coggill PC	anon	Gene3D, pdb_1t8s	Domain	This is the N-terminal domain of bacterial AMP nucleoside phosphorylase (AMNp). The N- and C-termini form distinct domains which intertwine with each other to form a stable monomer which associates with five other monomers to yield the active hexamer. The N-terminus consists of a long helix and a four-stranded sheet with a novel topology. The C-terminus binds the nucleoside whereas the N-terminus acts as the enzymatic regulatory domain. AMNp (EC:3.2.2.4) catalyses the hydrolysis of AMP to form adenine and ribose 5-phosphate. thereby regulating intracellular AMP levels [1].	20.90	20.90	20.90	22.20	19.30	20.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.90	0.71	-4.66	67	952	2009-01-15 18:05:59	2007-10-18 11:24:16	4	3	935	27	168	567	55	159.40	47	32.95	CHANGED	ttAVs+LppLY-pusshLpsshpphl.sGs.PsschRA....hYPplRlsssshups......coR..uaG+VstPGsYuTTlTRPcLFcsYLtEQlpLLhpsHsVslpVGsSspsIPhpFslsssstlp.sstssstc......LpchFssPDLushsDcIssGh.apstsstshP	........................s.pAl-+LctLYEpulsALRsAlupYlpsGpl.....P.D.ppsRtt...........FsYPpLsVoaDuss............ps......c..........TR..AaG+hocsGsYoTTlTRPsLFRsYLpEQLsLLhp-YGspIsVpsSppcIPYPYVl-uup.Ls..l.Dcohu.A.s......LschFPTT-LAplsD-hADGlacPsphpP......................................	0	21	76	119
+10257	PF10425	SdrG_C_C		C-terminus of bacterial fibrinogen-binding adhesin	Finn RD, Coggill PC	anon	Gene3D, pdb_1r17	Domain	This is the C-terminal half of a bacterial fibrinogen-binding adhesin SdrG. SdrG is a Gram-positive cell-wall-anchored adhesin that allows attachment of the bacterium to host tissues via specific binding to the beta-chain of human fibrinogen (Fg). SdrG binds to its ligand with a dynamic "dock, lock, and latch" mechanism which represents a general mode of ligand-binding for structurally related cell wall-anchored proteins in most Gram-positive bacteria. The C-terminal part of SdrG(276-596) is integral to the folding of the immunoglobulin-like whole to create the docking grooves necessary for Fg binding. The domain is associated with families of Cna_B, Pfam:PF05738 [1].	20.50	20.50	20.50	21.20	19.10	18.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.02	0.71	-4.27	35	1380	2009-01-15 18:05:59	2007-10-18 15:44:03	4	52	266	14	22	1140	1	161.70	27	17.80	CHANGED	sshsssthsslsu....pIps...lsppssp..asphlYVNPpppshppss.....lslpG............phspuushsssssplKlYcVsss.ppLscShhssh.s.sphcDVTsph.............phohssNs.phslsFs..slsps..YVl+hsGcasssusp...lshpopLsuhsppt........h..ssshsasN	.....................s.thspppssslpu....plsp...lspsssp..appslYVNP.p..p....s...hssss.............l.lpG................phssuuplssss.splKlYcVsss..s.......p......LscSahsss.........ophcDVTsph..................ploassss..shslsFs....clsps...Yll..hVsu+a-ssuss..slshpsslpshssph...............hssthsas.......................	1	9	10	20
+10258	PF10426	zf-RAG1		Recombination-activating protein 1 zinc-finger domain	Finn RD, Coggill PC	anon	Gene3D, pdb_1rmd	Domain	This is a C2-H2 zinc-finger domain closely resembling the classical TFIIIA-type zinc-finger, CX3FX5LX2-3H, despite having a valine and a tyrosine at the core instead of a phenylalanine and a leucine, hence CX3VX1LX2YX2H.  The structure, nevertheless, contains the characteristic two-stranded beta-sheet and alpha-helix of a classical zinc-finger. The domain binds one zinc and, in complex with the zinc-RING-finger domain, helps to stabilise the whole of the dimerisation region of recombination activating protein 1 (RAG1) [1]. The function of the whole is to bind double-stranded DNA.	20.70	20.70	21.00	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.46	0.72	-3.98	53	4732	2009-01-15 18:05:59	2007-10-18 16:00:50	4	15	3377	1	20	4638	0	29.20	66	5.20	CHANGED	LslRCPVK-CcEEVhLGKYs+HlSSHKEs+	.......LslRCPVK-CcEElhhGKYupHLSSHKEhK.....	0	1	2	4
+10259	PF10427	Ago_hook		Argonaute hook	Bateman A, Wood V	anon	[1]	Motif	This region has been called the argonaute hook [1]. It has been shown to bind to the Piwi domain Pfam:PF02171 of Argnonaute proteins.	23.00	23.00	24.30	24.30	21.50	22.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.80	0.71	-11.98	0.71	-4.13	36	202	2009-01-15 18:05:59	2007-10-19 10:48:31	4	10	53	1	85	153	0	133.70	41	8.72	CHANGED	GpPosPh..ssV..............................cp..GsuhWG+sssS.ssh.tstssssssouWGs....sssuss....suspshpssW..s-csssshus...........suWp-ptssssGh...Ws..spsSp.ssuSh.suuWupt.sst....tthct....uhhu.uphttcuh.hu+	...........................................................h..................................DN..GTSAWG+Ps....so....usu.....WG-...s.ssssssuW....Gs..s.....ssusssh.............KsuuKSMQ..D.GW..GscDhslsusR....suWEEE-..-GGh...WN..osuSQtS.sSS...hssuuWGpt.usK..........+phpp......uhts..Gs..s-uW.MN.....................	0	6	14	35
+10260	PF10428	SOG2		RAM signalling pathway protein	Mistry J, Wood V	anon	Pfam-B_35594 (release 22.0)	Family	SOG2 proteins in Saccharomyces cerevisiae are involved in cell separation and cytokinesis [1].	25.00	25.00	87.00	42.90	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.40	0.70	-5.83	17	158	2009-01-15 18:05:59	2007-10-19 11:53:20	4	23	126	0	122	165	1	355.20	22	46.12	CHANGED	ah+RLSsLP.....Ecctppps.......................h-sllEus+GlLFulhQlpstlp.tlhslspccssppsslc......lhYssssHl-pL.psLcph-stspss.........hpppslhctChohlsuap+lhs.LppslcthhssuDsRYlRshhh.lasShhElpNuhstlss..t..........ppt.........s...h....tp.t.tshhpspphosTts+.sshs.pp.ps................................................sslpps..........................................................phsssss...........................pspscssphs.......s...s.ssPposcoh.shsssssspls..................s..t.spst-cpl....cplappLpsssshshpslsplppphs+shtsuppspp...scsltt....................................hhpsLhcpCpsshclocsLppRLsshp............................................p-sh.shpsphpaW...chspuFlc.................uhlsllsph+plpssh.h..ss-lhshLtslp+uoK-sshllphSsaphl	........................................................................ah+RhS.LP.....Ep.p..hp.pth.................................................................hts..llcsu+tlLauh.plpstlp.thhshhpstp..hpt.s.lp......lhYsspsal-pL.ptlpph-p.stpt...........spslhctC.shlsuatplhs.Lttslphhhs...psDs+alR.l.hhhlasShhElpssht.lss..................................t.............................................h..............ssp...t.t.........t................................................................s.....................................................................................................................................................................s.......................................t..tts.......................sstssp.h...s.t.....t.t............................s..t..p.pph....cpla.tLppshphs.pshs.hppthsphh.t.....uttppt....spthh.....................................................hhppLhppCt.shphochLpp+Ls.hp............................................pps..s.tsp....htha...p.hpsFlp...................shhphhs.th+th...s.h.h...s-hh..htslpcsh+-sshhlt.Ssap.............................................................................................	0	32	67	106
+10261	PF10429	Mtr2		Nuclear pore RNA shuttling protein Mtr2	Finn RD, Coggill PC	anon	Gene3D, pdb_1q42	Domain	Mtr2 is a monomeric, dual-action, RNA-shuttle protein found in yeasts. Transport across the nuclear-cytoplasmic membrane is via the macro-molecular membrane-spanning nuclear pore complex, NPC. The pore is lined by a subset of NPC members called nucleoporins that present FG (Phe-Gly) receptors, characteristically GLFG and FXFG motifs, for shuttling RNAs and proteins. RNA cargo is bound to soluble transport proteins (nuclear export factors) such as Mex67 in yeasts, and TAP in metazoa, which pass along the pore by binding to successive FG receptors. Mtr2 when bound to Mex67 maximises this FG-binding. Mtr2 also acts independently of Mex67 in transporting the large ribosomal RNA subunit through the pore [1].	23.70	23.70	23.70	24.10	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.18	0.71	-4.49	7	52	2012-10-03 02:27:24	2007-10-19 13:07:04	4	1	50	4	32	75	0	161.10	37	88.94	CHANGED	ss.sQ.........s-sFlKKlLApLD......p.ps.sclppalp.F..........ppstIlhNupPhuss......stFLphW.ptsshTpHtlouhDhHlIP..GoGThlsNsssKVRF.DESGRD+hGpsusl.h..............sspshscsRPlWGoaaGlsLpLllD-plhpss.stsIsShNYphVa+P-DSllpI	....................s.s.sphhpsFlK+lLApLD........s.ss.splspalshF..........s.sspIIhNusPhups......stFhphWpsps.tTpHtLouhD.....h...H..sIP......GoG.....Thl..hNsssKVRF.DE..SGRs+hGpsAsl..tss..............ss.spsRPlWGsaFGlslpLllD-plhpss.stlIsuaNYphsY+P-DSllpl.....................................................................................	0	8	17	28
+10262	PF10430	Ig_Tie2_1		Tie-2 Ig-like domain 1	Bateman A	anon	Ciani B	Domain	\N	25.00	25.00	49.50	48.00	23.40	16.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.32	0.72	-3.63	4	53	2012-10-03 02:52:13	2007-10-19 13:35:17	4	11	28	2	19	50	0	95.50	79	9.53	CHANGED	AMDLILINSLPLVSDAET.SLTCIASGW+PHEPI.TIGRDFEALMNQHQD.PLEVTQDsTREWAKKVVWKREKASKINGAYFCEGRVRGpAIRIRTMKM	.AMDLILINSLPLVSDAET.SLTCIASGW+PHEPI.TIGRDFEALMNQHQD.PLEVTQDVTREWAKKVVWKREKASKINGAYFCEGRVRGEAIRIRTMKM	0	1	2	6
+10263	PF10431	ClpB_D2-small		C-terminal, D2-small domain, of ClpB protein 	Finn RD, Coggill PC	anon	Gene3D. pdb_1qvr	Domain	This is the C-terminal domain of ClpB protein, referred to as the D2-small domain, and is a mixed alpha-beta structure. Compared with the D1-small domain (included in AAA, Pfam:PF00004) it lacks the long coiled-coil insertion, and instead of helix C4 contains a beta-strand (e3) that is part of a three stranded beta-pleated sheet. In Thermophilus the whole protein forms a hexamer with the D1-small and D2-small domains located on the outside of the hexamer, with the long coiled-coil being exposed on the surface. The D2-small domain is essential for oligomerisation, forming a tight interface with the D2-large domain of a neighbouring subunit and thereby providing enough binding energy to stabilise the functional assembly [1]. The domain is associated with two Clp_N, Pfam:PF02861, at the N-terminus as well as AAA, Pfam:PF00004 and AAA_2, Pfam:PF07724.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.63	0.72	-4.08	772	19559	2009-01-15 18:05:59	2007-10-19 14:59:04	4	59	4882	83	4604	13942	5521	81.80	27	12.29	CHANGED	LsccplppIlcl.....lp.clpp.+L..t.c...cp.l.pL..clo-sAhc.hlucp.G...aDstaG.ARPL+RhIQcplcssL.........ActlL....pGp..lt.p.Gspl..pl	.............................................Lsc-slhpIlsh.....tLs..chh.p.p..L...........h.p....cs....lpL.cho-p.A..hc...h...l.Acp..u.......h.....-...........p.....h.....G.ARsL+pll..pc....tlpc.l...............schhl..ttp.h..................................................	0	1527	2924	3867
+10264	PF10432	bact-PGI_C		Bacterial phospho-glucose isomerase C-terminal region	Finn RD, Coggill PC	anon	Gene3D, pdb_1tzb	Domain	This is the C-terminal half of a bacterial phospho-glucose isomerase EC:5.3.1.9 protein which is similar to eukaryote homologues to the extent that the sequence includes the cluster of threonines and serines that forms the sugar phosphate-binding site in conventional PGI. This domain contributes a good proportion of the active catalytic site residues. This PGI uses the same catalytic mechanisms for both glucose ring-opening and isomerisation for the interconversion of glucose 6-phosphate to fructose 6-phosphate [1]. It is associated with family SIS, Pfam:PF01380.	24.50	24.50	24.90	24.60	23.70	24.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.68	0.71	-4.52	29	276	2009-01-15 18:05:59	2007-10-19 17:18:44	4	2	269	10	113	214	335	153.00	27	45.09	CHANGED	hpphps.A+pLAttlts..tlPllaus.shhtssAhRaKsplsENAKhPAhhshlPEhsHN-lsuhpss...........................htphthlllpsp.-p.ps............thhhshspclh.tpsssshplcsp...usS.hLpclhtLlhlsDasSlaLAhhhGlDPhslshIsthKccls	..............................h...hsN.AKsLAttLss...thPllaus.sshssssucRhtp.hscsutp.Ahsushsch.......+shlsuhtts................................s.ts+h.lllltDc.s.-ttcs.................................tthc......hcpl...h......ts+ssslppl.ph......tu....o.slp+hsuLlhhusaAulYLAltht.................s........................................	0	54	87	103
+10265	PF10433	MMS1_N	MMS1;	Mono-functional DNA-alkylating methyl methanesulfonate N-term	Mistry J, Wood V	anon	Pfam-B_64607 (release 22.0)	Domain	MMS1 is a protein that protects against replication-dependent DNA damage in Saccharomyces cerevisiae [1]. MMS1 belongs to the DDB1 family of cullin 4 adaptors and the two proteins are homologous. MMS1 bridges the interaction of MMS22 and Crt10 with Cul8/Rtt101 [2].  Cul8/Rtt101 is a cullin protein involved in the regulation of DNA replication subsequent to DNA damage.  The N-terminal region of MMS1 and the C-terminal of MMS22 are required for the the MMS1-MMS22 interaction [3]. The human HIV-1 virion-associated protein Vpr assembles with DDB1 through interaction with DCAF1 (chromatin assembly factor) to form an E3 ubiquitin ligase that targets cellular substrates for proteasome-mediated degradation and subsequent G2 arrest [4].	24.50	24.50	24.50	24.70	24.40	24.00	hmmbuild  --amino -o /dev/null HMM SEED	504	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.68	0.70	-6.36	38	910	2009-09-11 06:56:25	2007-10-22 15:39:32	4	19	291	34	656	897	17	467.30	21	40.61	CHANGED	p...hLhluhcS...tclhhLthpp................................psss.......Fh......pshsssssphpphGpplslDPpuRshulsuhpshFtla.Lpp.............ht.phhttst.tsPl...hp........................-GhIhphsFLa...stsssss.hlhhLhhs..ppppschhsYc............Wpsspslppshs+hshs....lssphclP.....shlIPLsp..................ssuallVsspphhlap..........st.......phhshphs............hppsslhssasts............................hppptcclhLsc-sGplhhltlsptst..........php.lGp..sslsssFshLcss........t..lLhsuustGs.uhhlphs.......................................................hspschlpch.NWuPllDhsllc..pppssp....t...............classSGsu.pcGulpplRpGlpup.thphshpph.s.spslWsls.....tssts....ssallhShPhpotlLpl.......................Dhs--l..ht....ulshsspTLtsushs...sshllQVTssulplsshtstphtpphp...........sspplhsAsssssphLlsssspstptlplpht+h.........h.ppt.ph......h..spssslshp...Ph	......................................................................................................................................................................................................................Dhlhlsocp...hphhhlpap.................................ttpth......t...........tshtc.shhp...sG.hhh.lDPp.uRhhhlthh.ct.hhlh.hpp....................p..tt.thtt..l........p.....................................................ph.l.hsh.hhl..................uhtpPhhhh.......l..s..............tpt..t........ph...h..hhc....................................................................................ht...h....sh.p.ch.p.s...........h....phs.............shllsVPt...........................................s..uG.ll.lh.spp.lhYp..........................t...............th......................................................ppshhhsh.....................................................hthsh.hh.L.lt..s.c.tGclahltlphspp..............................lppl+lphh.....s.....p...ss.ls..ss.hs..hLcsG...............hlFluSchGs.s.L.hphs.......................................................................................................................................................................hp.pltl..l...-phs.....sluP..l.hDhpl..s..ch.tp.p.sps...........................................plhsssGts...tc..uoL+ll.RpGltlp.......-hs.s...-LsG..spslWol+.......................................tp.pc..........hcsal..ll..S.....a..s..s....t.Th...lLpl..............................................p.s-.El......pt..GFhs.s.t..Tl.hsupls.....................pstll..........QVpsp.....u.lR...h.l..........................p...s..t.....t...h..hp..p....atss...................ttpsIstsu..ss.p..pp.lllshs.stp.l.hhhph.p.t................................................h........................................................................................................................	0	225	359	545
+10266	PF10434	MAM1		Monopolin complex protein MAM1	Mistry J, Wood V	anon	Pfam-B_58835 (release 22.0)	Family	Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae, that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [1][2]. MAM1 is required in S. cerevisiae for monopolar attachment [3].	25.00	25.00	60.40	60.40	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.08	0.70	-5.20	3	26	2009-01-15 18:05:59	2007-10-24 10:37:39	4	1	25	0	15	26	0	249.80	48	85.97	CHANGED	+cKRsLSsKDTNV.....lp.sNp.ppRpRsL+NKsoh....IsDSSslppPpKNscccpLsKassERpl+RhoNssNlssp-sNs.................pp..oQ+I-NNsAs+E...uG-sLTRssL+ELQppIh-hElssF.pCcHulCsQ.hshcsLcpsRTWFLFELEMoEstsc....NLRpSCYsKYVYoAIDpSW+hsNhLhcAs-supEaFPIEQLLIPc.plD.psppKth-....IEslSI-h-SIhETN+sss.pthV+KKpLPsSVLp+Rsc+clFDEhslDAcEVlNshSoSSS	...................................pKRsluNKDsNh.......l+.sNphpphSRhLspK.......IpsosspcpP+...KNhpccsLsSa+p.-+Sl+.KpNssNlssc-cK-...........................TQcLp...NNlsscE......uscs..LT+sNLKcLQccIF-pEhs.sI.sCcHsLCSs....ENR+..c..IKaSRLWFLFEL-MSt.Nhsc....NLRhSCYsKaVYsAIDcuW..phENILh...cEp-K+Y.........EaFPIuQLLIPN..sIDassc....pK+ccN...I.EDLTlEI-SIIETNHp..........cKRaLPpSlLhKRccchAFDDh.cLDA+KlLNDhSAoSp........	0	1	6	12
+10267	PF10435	BetaGal_dom2		Beta-galactosidase, domain 2	Finn RD, Coggill PC	anon	Gene3D, pdb_1tg7	Domain	This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain is made up of 16 antiparallel beta-strands and an alpha-helix at its C terminus. The fold of this domain appears to be unique.  In addition, the last seven strands of the domain form a subdomain with an immunoglobulin-like (I-type Ig) fold in which the first strand is divided between the two beta-sheets. In penicillin spp this strand is interrupted by a 12-residue insertion which forms an additional edge-strand to the second beta-sheet of the sub-domain. The remainder of the second domain forms a series of beta-hairpins at its N terminus, four strands of which are contiguous with part of the Ig-like sub-domain, forming in total a seven-stranded antiparallel beta-sheet. This domain is associated with family Glyco_hydro_35, Pfam:PF01301, which is N-terminal to it, but itself has no metazoan members.	21.70	21.70	21.90	22.00	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.03	0.71	-4.93	38	264	2009-01-15 18:05:59	2007-10-31 12:16:33	4	20	163	6	155	264	1	166.00	27	16.75	CHANGED	.LstTsttus.sosYo.ssssltso.Lhs......ssTtuuFYVlpHschoStssssapLplsTSs.GslTlPphsG.olsLNGR-SKIhVTDaslG.u.psLlYSTAElhTatphss.c.sVLVLYussGEpsEhAl......uspupshslcGpssslshpptsusllls.aspssshpllplss.....lclhLLDRssAYpa	......................................................s.....hs.sssslhsh.lhs......sto.stFalh.pp..tp.ss...ssts..aplpl..s...T.o.t.Gs.l.slPp.s.......u....slpLsGR-S.K.lhlsDasl......G..s......p........pLlYSTA-lhThtphss.c.sVll.LaGs.tG-tsEhsl....phs.s.t..s.p..s.slpG..sphsh.p.tps........s...t..l.hls..asp.sssh..p.hlplsss.....lhlhllD+psAhp.......................................................	0	48	88	127
+10268	PF10436	BCDHK_Adom3		Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase	Finn RD, Coggill PC	anon	Gene3D, pdb_1gkz	Family	Catabolism and synthesis of leucine, isoleucine and valine are finely balanced, allowing the body to make the most of dietary input but removing excesses to prevent toxic build-up of their corresponding keto-acids. This is the butyryl-CoA dehydrogenase, subunit A domain 3, a largely alpha-helical bundle of the enzyme BCDHK. This enzyme is the regulator of the dehydrogenase complex that breaks branched-chain amino-acids down, by phosphorylating and thereby inactivating it when synthesis is required. The domain is associated with family HATPase_c Pfam:PF02518 which is towards the C-terminal.	20.90	20.90	21.20	21.60	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.12	0.71	-4.73	57	905	2009-01-15 18:05:59	2007-10-31 13:35:54	4	12	296	36	574	859	9	170.50	32	40.88	CHANGED	sslSL+phlpF...Gp.ps.............sppp....hh.uupFlppELPlRLA++lp-lppLPhslsppPsltpVpphYhpSFcclhp..a...............................................................................................................pshc-....................spc...Fs.chLpplhpcHs..sl.lsolApGlhEh+..cth........................ssp.......plppFLDcahhuRIuh....RhLlsQH........................lsL.................t..t.psst................................ssa.lGhIss	..................................................................................................................slShcphlpF....Gp...s............................................sppp.....h.SspFlp.pELPl.........RLApplc-lptLP..tlsp...pP..........s.lptV.psh.Yh...pSFpclhp..a...............................................................................................................................p....c.s.hcc.......................t.p.c.Fs.chltplhpcHs..sV.lsshApG...llEh+.cth............................ssp.......................plphFLD+ahhu..........RIuh....RhLhsQH........................ltL...........ht..t.t.sst...........................................spa.lG.Is...........................................................................................................................................................	0	171	289	439
+10269	PF10437	Lip_prot_lig_C		Bacterial lipoate protein ligase C-terminus	Finn RD, Coggill, PC	anon	Gene3D, pdb_1vqz	Domain	This is the C-terminal domain of a bacterial lipoate protein ligase.  There is no conservation between this C-terminus and that of vertebrate lipoate protein ligase C-termini, but both are associated with the domain BPL_LipA_LipB Pfam:PF03099, further upstream.  This domain is required for adenylation of lipoic acid by lipoate protein ligases. The domain is not required for transfer of lipoic acid from the adenylate to the lipoyl domain. Upon adenylation, this domain rotates 180 degrees away from the active site cleft. Therefore, the domain does not interact with the lipoyl domain during transfer.	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.81	0.72	-4.31	94	2280	2009-01-15 18:05:59	2007-10-31 14:37:17	4	6	1825	11	300	1274	29	85.30	33	26.19	CHANGED	coPcFshpppcRFsh.Gtl-lplsVcpGhIpch+IaGDFhus.ts.lpclpptL.hGhpYctcslppsLppl..shp.pYhs.slph--lhphl	...................puPpFshppscRFsh.G.t.V-l..phsV.c.c.GpIpcs............+.Ia....GDFFu....t............-...l.p.slcptL....pGs..pY..c..t..-s..lpps.Lcsl..slscY.hs..slphcElhphh.................................	1	115	189	254
+10270	PF10438	Cyc-maltodext_C		Cyclo-malto-dextrinase C-terminal domain	Finn RD, Coggill PC	anon	Gene3D, pdb_1h3g	Domain	This domain is at the very C-terminus of cyclo-malto-dextrinase proteins and consists of 8 beta strands, is largely globular and appears to help stabilise the acitve sites created by upstream domains, Cyc-maltodext_N Pfam:PF09087, and Alpha-amylase Pfam:PF00128.  Cyclo-malto-dextrinases hydrolyse cyclodextrans to maltose and glucose and catalyse trans-glycosylation of oligosaccharides to the C3-, C4- or C6-hydroxyl groups of various acceptor sugar molecules.	22.20	22.20	22.20	22.90	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.30	0.72	-3.92	32	208	2012-10-02 20:10:03	2007-10-31 15:17:05	4	4	182	12	58	208	92	79.20	31	13.36	CHANGED	cLhHa.sP.psGlYVYhR................................h.sscoVhVlhNpsscshsLsLsRFpEhltssssup-llo.spphsLsc....sLslss+ushllpl	.............hh+F.hP..ppGlYVYtR................................phsscoVhVllNsscpp.tslsls+apEllssps.supDllo.G+pls.Ls.c....slsLss+sshlLEh................	0	21	43	54
+10271	PF10439	Bacteriocin_IIc		Bacteriocin class II with double-glycine leader peptide	Coggill P	anon	Manual	Family	This is a family of bacteriocidal bacteriocins secreted by Streptococcal species in order to kill off closely-related competitor Gram-positives. The sequence includes the peptide precursor, this being cleaved off proteolytically at the double-glycine. The family does not carry the YGNGVXC motif characteristic of pediocin-like Bacteriocins, Bacteriocin_II Pfam:PF01721. The producer bacteria are protected from the effects of their own bacteriocins by production of a specific immunity protein which is co-transcribed with the genes encoding the bacteriocins, eg family EntA_Immun Pfam:PF08951. The bacteriocins are structurally more specific than their immunity-protein counterparts. Typically, production of the bacteriocin gene is from within an operon carrying up to 6 genes including a typical two-component regulatory system (R and H), a small peptide pheromone (C), and a dedicated ABC transporter (A and -B) as well as an immunity protein [1]. The ABC transporter is thought to recognise the N termini of both the pheromone and the bacteriocins and to transport these peptides across the cytoplasmic membrane, concurrent with cleavage at the conserved double-glycine motif. Cleaved extracellular C can then bind to the sensor kinase, H, resulting in activation of R and up-regulation of the entire gene cluster via binding to consensus sequences within each promoter [2]. It seems likely that this whole regulon is carried on a transmissible plasmid which is passed between closely related Firmicute species since many clinical isolates from different Firmicutes can produce at least two bacteriocins. and the same bacteriocins can be produced by different species.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.56	0.72	-3.85	35	1162	2012-10-02 23:56:30	2007-11-06 13:42:44	4	3	367	0	62	351	0	66.30	33	90.98	CHANGED	M.........pphcsLspcpLusl.G.....G.........phspshsuhsuusssGshsGushus...........sGuhsGA......hhGussGuluGt	.........pphM.....hpQFphMDsEMLusVEG..G........sths.s..shsu.ssu......uA.s....s.G.hth.Ghtsssh..............hsuhhGu......hhGuhhsuh...h.......................................	0	6	29	42
+10272	PF10440	WIYLD		Ubiquitin-binding WIYLD domain	Bateman A, Thorstensen T	anon	Thorstensen T	Domain	This presumed domain has been predicted to contain three alpha helices. The domain was named the WIYLD domain based on the pattern of most conserved residues [1]. It binds ubiquitin. In the Arabidopsis thaliana histone-lysine N-methyltransferase SUVR4, Swiss:Q8W595, binding of ubiquitin to this domain stimulates enzymatic activity and converts its activity from a strict dimethylase to a di/trimethylase [2].	21.10	21.10	21.60	21.10	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.08	0.72	-4.04	8	79	2009-01-15 18:05:59	2007-11-08 17:56:48	4	5	15	\N	49	87	0	63.40	36	13.75	CHANGED	M..ss....p....cRhDAAh-+M+phGhccshlpsslKpLLp..lYscN.WhLIE-DNYcsLlDtIFspc-cp	....................tp....pRhcsAhctMpthGhscppl+sllcpLLp..lY..s....pN..W.hIE-.-sY+sLhDslh-pp-p......	0	5	28	41
+10273	PF10441	Urb2		Urb2/Npa2 family	Bateman A, Wood V	anon	Pfam-B_28626 (Release 22.0)	Family	This family includes the Urb2 protein from yeast that are involved in ribosome biogenesis [1].	21.30	21.30	21.30	21.30	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.29	0.70	-4.75	26	228	2009-01-15 18:05:59	2007-11-19 11:21:27	4	4	205	0	167	223	0	220.80	21	16.86	CHANGED	sssphlsthlphlp...phltpc..shhhsQhsl-hllsllsslst............................p.t.pspsslahphspllsslLthHRh+lss+hHllhsshspLLphLh......sptphssssss.........................ApthuRLlsphs-P.....................p.p.ttts..............Lssthsth+c.hs+ahshlLssYlphplphs.....lsssl+ptLpsGlYuIhDlho..........pp-.lphlsuuLDsuu....RshF+sLYs-Yp+huKWp.p	.....................................................................................................................................................................................t.......hhpsl....hllppc..shthsp.hsls.hlshlsslss.................................sth.pspth.sslahtlppllt....sllpp.....Hpphh.tph.hllsshppL.lpslh.....ttptspt.stss.sps..................................................shphuRL...lpphhp.......................................................................hsttpcthsp.ah.al..lhpY......lph.hcss.......................lhspl+ptLpsGlY....sll....Dlhs..........cps.hphlpuuL...ssuu.......Rs....lFKpLYs-Yt+atKap.pt.......	0	46	84	131
+10274	PF10442	FIST_C		FIST C domain	Borziak K	anon	Borziak K	Domain	The FIST C domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [1].	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.74	0.71	-4.23	188	1182	2009-09-11 08:20:13	2007-11-19 11:45:35	4	33	821	0	440	1024	155	135.40	19	29.02	CHANGED	AhphYpchlu.....t.t.t........pphst..........................hPlul........t.......................h.ssphh...........................................lRslhtls.tssul.shhsslppGtplphh.ts..spshhpshpphhpph..........................................t..tsthsl.hhsChuR...hht.pt.tppc.lpt.lpchhstt..sl..........sGFhoaGEhtsh	.......................................................................................................thhtchlst..t..............pph...........................hslul....h.......................h..spp.h..................................lRshhth.s..s.sul.thh.s...s....l.p...G.pplph....tp..sssh...hcshppshpph.......................................ttttpstssl.hhsChuR..h.hht...t...t...sp-.hpt.lpphh..s....h.sh.........................sGFasaGElh..h................................	0	126	291	379
+10275	PF10443	RNA12		RNA12 protein	Wood V, Bateman A	anon	Pfam-B_18000 (Release 22.0)	Family	This family includes RNA12 from S. cerevisiae.  That protein contains an RRM domain.  This region is C-terminal to that and includes a P-loop motif suggesting this region binds to NTP. The RNA12 proteins is involved in pre-rRNA maturation [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.40	0.70	-5.99	18	149	2012-10-05 12:31:09	2007-11-19 12:57:18	4	12	135	0	119	171	38	416.20	37	49.99	CHANGED	Rp-clcpLppWLtEsssTFlVlpGPRGSGK+ELVh-+sLpsccp.............sLhIDCcplhc.ARsDsthIsssAsQlGYhPVFSWhNSlSuhlDLAsQGLTGpKuGhSEopEuQlpshLpsospAL+cIuLppp...................ccsDcss..........................................................slp---YLptHPEt+.................PVlVIDpF......hp+ucp..suhlYcclu-WAAsLVpsNIAHVIFLTsD.VuhsK.LocALPNp...VF+slsLuDsS.csA+paVlspLtt.......................................................................................................p...................ptstpppptsp.t.......................plp-LDssl-sLGGRhhDLpshsRRl+s.G-oPccAlschIpQuus-IhphFLt........t.tssspsWospQAWpLIcpL...Spsssl.Ys-llhssLFKu.......ssEs..uLpsLEpuELIolsp.ssGpsscI+sGKPlYpAAFppLlsDcslpsthchthlsplIshEsscIcKhE-ELphL.ucl	.............................................Rh-tlpplpt.WLhEsssT..FlllpGP....+GSGKcELVhcpsLps.ccp.............hLlIDCc.l.c.A.+uDsshIpshAsplGY.hPVFoWhNS..lSuhlD.LAs....QGhhGtK..uGhSEoh-sQlp.........pILpsospAL+pluLppp..............ppsccss........................................................................................................................................................plp---aL..ptH..PE.t+..........................PVlVIDsF......hp..K.u.cp...sshlYcclu-WAA.sLsps.N.IAHVIFLTsD.luhsKsLucALPsp...VF.+sl.sLuDsS.-su+paVlspLps...........................................................................................................p..................................................................................pphp-LDssIcsLGGRhoDLphhsRRl+s.Gp.oPppAVpcIlpQuus-I...h+halh...........t.ssp.sppWos.pQAWhLI+tL.................up..psslpYs-llhsslFKu.........ssEs..sLpuLEpuELIolpp.ppGpsppI+sGKPlapAAFppLhp.Dphlpsph-hthltpllphEsppIpKhEpELthLup.h.............................................................................................	0	41	73	105
+10276	PF10444	Nbl1_Borealin_N	DUF2455;	Nbl1 / Borealin N terminal	Mistry J, Hartsuiker E, Wood V	anon	Manual	Family	Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation.  In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p.  In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles.  Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localisation, stability, integrity, and function [1].  The N terminus of Borealin is homologous to Nbl1 [1].  This family contains both Nbl1, and the N terminal region of Borealin.	21.20	21.20	21.20	23.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.41	0.72	-4.60	17	162	2009-01-15 18:05:59	2008-02-06 12:35:15	4	4	136	5	116	162	0	58.40	30	18.74	CHANGED	pphpshlpshshE.lpsRhccl+uphp.hhpshcsth-hclh+lPpulRchpht-lhsch	.........phpuhlcshphE.....l........ppRs+pl+uphp.hhpslcsphchcl.RlPpulRchsht-hhtph....	0	37	59	91
+10277	PF10445	DUF2456		Protein of unknown function (DUF2456)	Hartsuiker E, Wood V, Mistry J	anon	Pfam-B_97171 (release 22.0)	Family	This is a family of uncharacterised proteins.	25.00	25.00	32.10	31.20	24.00	20.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.31	0.72	-4.07	6	48	2009-01-15 18:05:59	2008-02-06 12:37:41	4	1	46	0	35	47	0	90.40	34	26.54	CHANGED	tsLcuh.pspFht..sphhhhpalEWhl.pslRGhlLulhhahhlWPlThGILAuIGp+.tpHDYYFNs..h.hPQVhKLIYGsVlGhlosPllAhlhh	..................hp...h..h......t.phhpalphhltphlRuhllulhhFlllWPlohGILuuIGp+...tupDahaps..h.hhPQlhKLlYGsVluhlsTPlhshlhh....	0	11	19	32
+10278	PF10446	DUF2457		Protein of unknown function (DUF2457)	Hartsuiker E, Wood V, Mistry J	anon	Manual	Family	This is a family of uncharacterised proteins.	30.00	30.00	30.60	32.00	27.10	29.80	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.77	0.70	-5.76	10	78	2009-09-13 16:18:35	2008-02-06 12:38:57	4	4	71	0	66	77	0	404.60	41	60.99	CHANGED	RFHEFASS..EDD-Wlpcs.ssaKpKlTlsDsMKKEpAIRKLGEEAE......EEAhEEE....................-tD-DDspDsDp-Dt..tpt-s...........DsDSslt.hsp..DDGNEoDNEAGFA-S.DE.oDstS-YsFWAPsusTsATos...psl-ssRpshsR+sSsoSh-Shscppsp+p....s.....ppspRpPhKss..+hRPuTPcLPDSTDFVCGTLDEDRPLEsAYhSChEtRRhuKplhIPQDIDPSFPTSD...P-DE-D-.pchp..hshpsD............-usRsRttt.ts++pSPtsSP+RhhSPPP..R.........+ttttS..P++L.RSPPPPh+h+Ss..................sttuusssssoh...sscGlsh..upLspRPshT+TKSLPRTPNsF.......p+hsthsPh.pusE+Euoss+-sHsRGsIDIVcGLEKKRQ+RKEKFaRpHC.RKAsKEphpR.RPhPGKGAERM+ELGLtsAcphhua..ulG...............psuphVLSV	................................................RFHEFuSu..c.-DDWlpps..sshppKlT.lsDs.h+KE.sIRKLGcE.AE........EEA.pEE....................----.--pp..-p-..t..pDp...pp.--..--.ptD....-tp.....-t......s-.s-....p.sp..sD..G.coDsEsGFA-S.DEsD.t.s-hthWsPst..sssssps...tshshhR..s...tc...pt.S....soShtShps.ts.p...............pRp...h+......+h.R.ssT..PsLPDSTDFVCGTLDEDRPLEsAYhSChptRRppKph.IPQDIDPSFPTSD...s..EDE.----..tcp...........ptps-.p..h.pt.........................-t.+sRt......tp+po.ptSP+RhpSPPP..R.......................+.hhupS..P++L.cuP.ss.hRh+SP..................sths.hpshss.....tstu.hph..tsLut...RPsh..s+T+SLPRsPs.F..............................+hp.t..s...tptp.pttspsp-.hHsRGsIDIVtGLE+KRQ+RKEKFappaC.p+A.tK-p.h.pc.....+P...hPG+GAERM+ELGL.hAt...............thu...............pss..hVLSl.....................................	0	13	31	52
+10279	PF10447	EXOSC1		Exosome component EXOSC1/CSL4	Mistry J, Wood V	anon	Pfam-B_6887 (release 22.0)	Family	This family of proteins are components of the exosome 3'->5' exoribonuclease complex.  The exosome mediates degradation of unstable mRNAs that contain AU-rich elements (AREs) within their 3' untranslated regions [1].	21.20	21.20	21.20	21.40	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.84	0.72	-4.03	32	355	2012-10-03 20:18:03	2008-02-06 12:46:39	4	8	310	1	250	337	11	79.70	41	34.22	CHANGED	lPchGslVlsRVoRls.+tApspILsV................................................sssshps........................sF+GlIRppDVRuTE+D+VclhcsF.+PGDIVRApVlSL	...............................lPpsGslVhs+Vocl.st+hAplpIlsV...............................................................ss...pslpp.....................................................sFpGlIR.ppDVR..uTE..+D+Vc.....h.....hcsF.RPGDIV+ApVlSL........	0	84	134	203
+10280	PF10448	chaperone_DMP	POC1; 	20S proteasome chaperone	Mistry J, Wood V	anon	Pfam-B_75798 (release 22.0)	Family	This family contains chaperones of the 20S proteasome which function in early 20S proteasome assembly. The structures of two of the proteins in this family (DMP1 and DMP2) have been solved, and they closely resemble that of the mammalian proteasome assembling chaperone PAC3, although there is little sequence similarity between them [2].	22.10	22.10	31.80	31.20	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.79	0.71	-4.30	18	73	2009-01-15 18:05:59	2008-02-06 12:51:02	4	1	39	6	47	72	4	144.80	21	96.35	CHANGED	Mphtphppphsst.s....................utcsclslp...thchssKhslsltlNuphDsohcs...sh............hsYhhsl..................pphtushpshlhlusus-hth.sl.spplucLls+phpsss.............hlolSS+hht......t.spssshphLhhlLcsl+	............................M..hphppphstt.t...................sstshplhlp...sschssKl.lsltlssphDsohcss.ps..................hshhhuh...........................ppphushpslshlGsssDhph.sl.spQlucLltcphts.s...............hlohS.S+hht.......ptsssschthLhhlLcslK....................	0	5	23	44
+10282	PF10450	POC1	POC4; 	POC1 chaperone	Mistry J, Wood V	anon	Manual	Family	In yeast, POC1 is a chaperone of the 20S proteasome which functions in early 20S proteasome assembly.	20.40	20.40	21.20	20.80	18.40	20.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.82	0.70	-5.64	3	40	2009-01-15 18:05:59	2008-02-06 12:54:17	4	1	38	0	25	39	0	242.90	33	98.06	CHANGED	MLFKQWN-hstP+H.LD.P.Iu+N.pSLplhPVPcVahPp.hDlspYpssVlTTKIMsPLFPppLLphppIu-IpTTLplcpsp.st-SEcHSWNY-ENFPNEV..s.KpDosscplhuFSaPIauFcDTLIhhIEENFIKhSAIFoNhIoRslIsp.LAQhsPDIp.IsI.GTSDKIsslKpLTpscCoLpPPEFITGFIGSlLTQL...PSKELKVFpsIVAPSEGPIGFEKhoLsslcuLVDlCucLLshcPSc...YSsEChRLWRLDuAAIGAQSGLYI	.........................................................................................................................MlhK.Ws-...P+H.lp..........psh..tshsp.l.h.s....ph..p.hp.hll......t...hhssLFP.cp.L...lphpplG..clpsols.lp...ts.p.......sps.sscc.sasaDEpa.spl........-...cpcst.pp.phhshphPI..aths..c..oLlhshp..-NFlphssI...hsN.hlo+pllsp...L.s.ph.....ps.....-..I...l....ll..us....S...........D+.Is..sh........K...s...ho......ps.....s.....oLpPPEFITGhluSlloQL.........sppshp..hpsLVssSEGP...GFEKlslsshssLlclhu...phLshpspp...Ysppsh+.W+httss...psGLYl.............................	0	3	13	23
+10283	PF10451	Stn1		Telomere regulation protein Stn1	Mistry J, Wood V	anon	Pfam-B_51291 (release 21.0)	Domain	The budding yeast protein Stn1 is a DNA-binding protein which has specificity for telomeric DNA.  Structural profiling has predicted an OB-fold [1]. This domain is the N-terminal part of the molecule, which adopts the OB fold. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [2].	20.90	20.90	21.50	21.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.60	0.70	-5.54	7	123	2012-10-03 20:18:03	2008-02-06 12:56:02	4	9	115	3	95	163	1	178.30	20	49.51	CHANGED	atchtpt.....VsaahspLh+hsphastsp..shhlpDl+pphc.Shphsp....YhshhtshlaWhN+PlppI+llGsllGhpa+hlttp-ahhhplDDCos............hLpCpspcsplhShuhslssh.lGhTlpVhGhhs.......hph.ELpVpalc.hshsLppEIcaWchshph+cpLshPWclss.hltt.hptcpcht.tt...............coPpppps......pssaIEpL...cphcscLplhSPasspsp...........s..lhs...hphlsstspl-pt	........................................htt...................................................................tshhFatN+.PlphlplsGhlluh.p..h.....................t..........c....h..hlh.s..lDDuSG.t...................................slps.......h.....st....tp......................................................G.hl.....plhG.hp..................................t..php...hp.h....hh.........s...httEhthWp.h.ph.h.....L....s.......................................................................................................................................................ttttttttt................................................................................	0	15	45	80
+10284	PF10452	TCO89		TORC1 subunit TCO89	Misry J, Wood V	anon	Pfam-B_61649 (release 22.0)	Family	TC089 is a component of the TORC1 complex.  TORC1 is responsible for a wide range of rapamycin-sensitive cellular activities.	20.20	20.20	20.90	20.50	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	613	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.16	0.70	-5.63	6	69	2009-01-15 18:05:59	2008-02-06 13:00:05	4	5	53	0	46	70	0	286.50	20	51.06	CHANGED	RQFST+SRuK...SsASFKG...L+RVhoHDGThsps.sh.spaushKKoKSSDuLh+RRslSGLsMTALst................puPlp..................huusGL+PcRs+popsVLsL+-upt.hDs-STTDEEVEhFo--p.c.........-Apss......-spstst+stPpppp.h.php.hptp.sh..st.cp.psh.tt..sh+s....hs+.lDSssthh........sc.pI-t......................S+ppppsaDussussslppslsstph.pp............s-h..........................................pt.sHsstpcc.pED+hsssspssp.spssApohtpttccuuptspssppppp..lsD-........p..t.scsp......-pYlPDMILSQSTGVER+F-pplShQNSLu.......................c.tst.s.pthcstphpcs+aNhlppplstsl.ssp...............psptsFSouISSLTssLpRssPpSh.sss+hNss.hp+spQp.L.Rtpph....tt................hspssppssSssplNsFuQFLpSsshsu-SRTQpKLWLQREsSIhDLsuQs.Duu-AlFhASNlEsKREFERIS+EYosVRRFtNPLs-uLpRlp.....ptpshppppppcusouhpuuS.s........hFssY.ppsKohcEhhssupp..hclpplLsuIWpSpotpFNKDsNPL	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ps............+ppFE+lspEY.sVRRahNPls-uL.Rlp.....................th.phppptt.p...s.........................................................................................................................................................	0	11	28	45
+10285	PF10453	NUFIP1		Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1)	Mistry J, Wood V	anon	Manual	Family	Proteins in this family have been implicated in the assembly of the large subunit of the ribosome [2] and in telomere maintenance [3].  Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA [4] and is phosphorylated upon DNA damage [1].	22.30	22.30	22.80	22.30	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.02	0.72	-4.46	39	274	2009-09-11 12:31:40	2008-02-06 13:04:56	4	9	247	0	202	267	1	56.50	29	11.43	CHANGED	htptphpshphpG.pplpL....p.T.sE-It+WhcER+KpaPTptplp....cKpptcctptcctph	.......................h.......hth.G...pphpL........p.o.sE...-ItpWhEER+KpaPTpsplc........cKc.phpptp.pctt...............................	0	74	112	166
+10286	PF10454	DUF2458		Protein of unknown function (DUF2458)	Hartsuiker H, Wood V, Mistry J	anon	Manual	Family	This a is family of uncharacterised proteins.	33.10	33.10	33.70	33.50	33.00	33.00	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.93	0.71	-4.32	9	64	2009-01-15 18:05:59	2008-02-06 14:04:39	4	3	62	0	52	65	0	144.90	32	61.78	CHANGED	DsppITsassAL+YVh+plspssch.pcIRcLIpcQccapcpahppR-tLlp+.puph-pp+cL.....-slLpslst.hsp..tp.sp.c.c.ptcLpthDtphhht.pph..t.hthhcsLplPhFhhpp..........................ht..clpp.phhhlplL.D.ltp	.............sphIssa.tAL+hlh+plupscshtpcI+cLIppQcc+E+pWapuRpsLltKQps+ttpp+pl.................cplLpslGs..lsp....p.sss......c........cpptELppa.D.pKVapA.ppMscthptcL+sLulPFFshpp.................................hstc-lpthph+hLplLpDhh.................	0	19	29	42
+10287	PF10455	BAR_2		Bin/amphiphysin/Rvs domain for vesicular trafficking	Mistry J, Wood V	anon	Pfam-B_12557 (release 22.0)	Family	This Pfam entry includes proteins that are not matched by Pfam:PF03114.	22.70	22.70	22.80	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.97	0.70	-5.49	10	190	2012-10-03 12:17:00	2008-02-06 15:55:33	4	5	139	0	139	628	1	273.70	37	82.41	CHANGED	oI.olss+Tp+hlpEpLGpVp.............DISpLPt-YlpLEpKsDsLcKlYp+lLhlo.cTaEs-uYDYPP..shsESlsD..aspolutKhpphtNhoSspcsphhhhGpstp-tsptpKt..................p.sss.hP+TLstALS+sAtcuo..hpcL........................................csp-hssLupshtphSss.tcIupA+h-pDphIlKcFNpcLcclLsppFtKsccLRKKVpcoRLpFDhhRpclcp...................................scPEsEE.............................................t.t..LEshEDEFVSATccAVhhMpcllcsSchlsLLKlFtssQLpYacpuscpLcp.LssLst	...................................................................................................................shAt+T.phlpEpLGpsp.......................................................................Dh.opLPt-Yl-LEc+lDuL+tlap+hLtVT.spYpsEuYDYPs..NlpEShsD..hu+olupKlp...LopAo..SssEA.pshL.hu.Pss.sc.................................PKThsa.Alu+Auhsuot.hpph....................................................ppsssp.cs.L.up.uLcpau.s.p+lupARLs.QDs.Ipo+...F.tshp.ssLNs.s...l...thAs.......+sRKsV-suRLphD..ss+sp..hcst...................................................pp.sph.pp...................................................................................................phchclE..pAED.......E.FVspTE.-.AlslMcp.V..l.-..s.....s.....-.s.L..cpL.t...-L...lsAQLpYa+puhchLpph......t..............................................	0	34	77	122
+10288	PF10456	BAR_3_WASP_bdg		WASP-binding domain of Sorting nexin protein	Coggill P	anon	Pfam-B_43522 (release 20.0)	Domain	The C-terminal region of the Sorting nexin group of proteins appears to carry a BAR-like (Bin/amphiphysin/Rvs) domain. This domain is very diverse and the similarities with other BAR domains are few. In the Sorting nexins it is associated with family PX, Pfam:PF00787.13, and in combination with PX appears to be necessary to bind WASP along with p85 to form a multimeric signalling complex [1].	24.90	24.90	24.90	25.70	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.56	0.70	-5.11	8	753	2012-10-03 12:17:00	2008-02-11 16:57:52	4	10	512	8	150	521	1	143.90	60	42.00	CHANGED	DEKsWKpGKRKAEKDEhVGusFF.TIs.Pph.ssLDLp-VEpKlEsFppFTKpMD-uVhpLpssusEah++psGsh+KEYQKlGpAFpsLupuFphDthstSusLNcAlutTGcsYEpIG-hFAEQP+pDLc.lh-sLs.Y+GhLuNFPDIIpVpKGAlsKVKESp+hstpu+lssp-tsshpcRssshSYAl.AEhpHFHspRlhDa+uhMQpYLcQQlpFYQcIupKLccALspYD	............................................................DDKQWKLGKRRAEKDEMVGAHFMLTlQIPs...EHQ.DLQDVE.ERlDsFKuFAKKMDDSVhQLTHV......AS.ELVRKHLGGFRKEFQRLGNuFQSISp..........A..Fh..L.D..P............P..h.t...S....ps....LspAls.............................................................................................................................................................................................................................................................	0	43	55	99
+10289	PF10457	MENTAL		Cholesterol-capturing domain	Coggill P	anon	Pfam-B_16187 (release 22.0)	Domain	Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops [1]. The function of the domain is to capture cholesterol and pass it to the associated START domain Pfam:PF01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localisation of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins [2].	20.50	20.50	20.70	20.80	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.43	0.71	-4.65	10	190	2009-01-15 18:05:59	2008-02-11 17:18:49	4	7	92	0	107	176	0	151.70	49	43.35	CHANGED	ScVRRpFCLFVTFDLLFloLLWIIp.lssscuIppsL-pEVl+Ys...a+sShFDIhLLAVaRFhlLlLuYAlh+L+HWasIAlTTslooAFLIsKVll...shhSQssFsalLsIsSFlLAWlETWFLDFKVLPQEscsEcha.luu..........................psss-RsPLLsPu..........slScGpFYSPs-Shs	..........................................S-VRRTFCLFVTFDLLFloLLWI....Ip...ls..s.ssuIpps.LcpEllp.Ys...atoShFDIh..lLAhFRFtsLl..LuYAl..h...+.L+...H.....WWsI.AlTThlooA...FLls......K...V.ll......ph........h............op....s.....s..FuYlLsIh....SFlLAWlETWFLDF+VLPQEscpcphh.hhs........................................p.ssstRss..ll.ss..............shSp...upFYSP.-o.u.................................................................................	1	26	35	66
+10290	PF10458	Val_tRNA-synt_C		Valyl tRNA synthetase tRNA binding arm	Bateman A	anon	SCOP	Domain	This domain is found at the C-terminus of Valyl tRNA synthetases.	25.10	25.10	25.10	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.03	0.72	-3.89	31	4203	2012-10-01 23:07:44	2008-02-12 16:38:06	4	17	4133	4	940	3276	1648	65.80	36	7.28	CHANGED	Dl-cEpuRLpKELt+lppElc+lptKLuNPuFlsKAPs-VVEpE+s+lt-hppphptl+ppLspLu	............sh-tElsRLpKEls.KlppEls+lptKLuNEsFVu+APptVlpcERcKhtchppphspl.pppltpl..........	0	326	626	804
+10291	PF10459	Peptidase_S46		Peptidase S46	Rawlings N, Mistry J	anon	Manual	Family	Dipeptidyl-peptidase 7 (DPP-7) is the best characterised member of this family.  It is a serine peptidase that is located on the cell surface and is predicted to have two N-terminal transmembrane domains.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	698	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-12.83	0.70	-6.11	61	519	2012-10-02 13:45:52	2008-02-15 12:22:33	4	2	290	0	157	649	484	661.60	34	96.35	CHANGED	ADEG.MWh.ppl...p..tsphpp.hGlclssppLhslstss.....hsAlVp.sGGCouuFVSscGLVlTNHHCuauuIQppSos-+saLpsGFhApsts-ELss.PuhplphlpplsDVTcplpsulp..shssptphptlpsthppltpc.sppcs......sh+spVtsFasGspYhLhphpcapDVRLVaAPspulGcFGGDsDNWhWPRHTGDFohhRsYsstsspPAtaups.NlPhpPcpaLplospGlc-GDashlhGaPGpTsRahsssplcpphchshPtplchhptthsllcphhppssch+lpY..AuphsuhsNhhKshtGhhculpchshlspKptpEsplttalppssph.tpatsshsplpthhppppphtppphhhppsht....ss.plhshAppLh+hspctp........pRttuhp-cshstlppplpph..psassslDctlhtthLsphtptsstpc.hsslpp.hlstpt........tt.....hpphscphastopLss.cshhthhpt.stsshps..scDPhlphAhul.hsthtthcpppcphsuthppspttahcAlhthh...spshYPDANtTLRloYGpVcG..Y..ss+.DuhhhssaTTlcGlhcK..p.sGstsFslPpphl-hhpsp-a...Gta..........................t.sssPVsFlossDhTGGNSGSPllNu+GELlGLsFDGNaEuluuDahassshsRsltVDhRYlLahl-clssAspLlcELsl	..................................................................................ADEG.MWh.ppl...p.....ttphpp.hGlplsspplas.stss.....hsAVVp.......h...sG.......G.CTuphVSscGLVlTNHHCuauuIQppSosE.+DYLpcGFhApohs-E.LPs.PshplphlpclpDVTcpVtttlp......st.s..tp...p...pt.....thlpshhpt.lspc.htpps...............shcsplhsFasGNcYaLhhhppapDVRLVhAPPpSlGKFGGDTDNWhWPRHTGDFShFRlYss.ts.spPAtYSt-.NVPh+Pc.paLtlShpGlc-GDasMlhGaPGpTsRYhsuttlcpthpht.ssthphpshphslh.ccthppssp..hRIpY..ASchAu.uNYaKNhhGh.culpchsllspKpttEpphttahpppsp.................t....p.atp.s.hsplpphhspppththpthhhppshh.......ss.....phhphA..hp...lhphttthp...................tct.......th.cpthtp.hppthpph..cs.a.s.plD+plht.thLptYtphss.t.pp.hs.sh.hp.hlspch........tss.....hpthl-t.haspSh.lsstp.........s.ht.......pah...........ptss.hpt..ppDPhlp...huhul..hsthhph.p...pphpphssphpttcphahpuhhchp.s....pshYPDANtTlRloYGpVpG..Y......sPp..Du.hhh.......s.aTThcGlhcK......c..sss...-FslPtc..lh-Lhpp.+-a...GpY........................s.t.GphPVsFl.ossDhTGGNSGSPlhNucG.ELlGLs.FDG.NaEulsuD....hs.F-.ssh.pRsIsVDlRYlLall-KhusAspLlcEhs...................................................	0	62	113	141
+10292	PF10460	Peptidase_M30		Peptidase M30	Rawlings N, Mistry J	anon	Manual	Family	This family contains the metallopeptidase hyicolysin.  Hyicolysin has a zinc ion which is liganded by two histidine and one glutamate residue.	20.20	20.20	20.20	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	366	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.16	0.70	-5.58	6	71	2012-10-03 04:41:15	2008-02-18 13:56:05	4	8	52	0	39	167	8	301.10	24	54.19	CHANGED	DsosRsATLppQsTA...oDGssVNhWVEsuE.suuKISsshlcsLsspFAs.sGuIYDhLpslGG.hWGPpu.tuohIs.ssQPlDIVIL......NF-+sGQPaGtlGYFWupNsFppuu..tPhSNcSlSLYLDoETLYLGGpsG..hpslloTMAHEuhHMQNFYRRuVhhGupYua-sWLEEMTAMhMEDhtSppIsssYNsIRDsRF.sYhsYtu.GuYNCuLhpa.TsaGssC-SYuVSGSLGGFLNRQh.GLsFYpsLLopsotosShuVLssAI+sApPuuoLu-tltpaussssuLhPssuuPAGFGaPuRpDusFoLPhIDPs..hhsulRoLs....sulPsTLpuaGoaPVsRosssGTYSETV+VPAGs......TLSVVVc	....................................................................hh...................ts...hh.hWltss..................plop...t.hpplhpcFss........tlYs......hhsslhGp.....s..................sps..s...t....ss.hls......h.Illh........s.h....p....s.s...spshG..h.....h.GYFaups.a....s......t...............tshSNpu..hYl...Dstshhh.ss.s.ss............sp.....h....huTluHEapHMlNF..p+s.lh.....p...s..tt.h.h-sWLpEhhuhshEc..hh.......utph..........................h..s.....sRhs.t.a.p................shs...sslhta...ss.......u.....ss..h..s..Yuhuh.hhtaL..h....cQh.....Ghsh..hhphl...s....s..tssptslhsssh.thsss..s.hsphhtpaths........t...st.asa.t...............................................................................................................................................................................................	0	9	18	26
+10293	PF10461	Peptidase_S68		Peptidase S68	Rawlings N, Mistry J	anon	Manual	Family	This family of serine peptidases contains PIDD proteins.  PIDD forms a complex with RAIDD and procaspase-2 that is known as the 'PIDDosome'.  The PIDDosome forms when DNA damage occurs and either activates NF-kappaB, leading to cell survival, or caspase-2, which leads to apoptosis.	20.10	20.10	20.60	20.60	19.70	17.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.60	0.72	-4.24	2	40	2009-01-15 18:05:59	2008-02-19 12:42:30	4	27	28	0	19	43	0	33.40	66	4.02	CHANGED	WssL.TtLcctu.+R.hatRspVP+FSWFhVV.RP	.......WuDL-TaLEEEuPpR.hWA+CQVPHFSWFLVVSRP.	0	1	1	7
+10294	PF10462	Peptidase_M66		Peptidase M66	Rawlings N, Mistry J	anon	Manual	Family	This family of metallopeptidases contains StcE, a virulence factor found in Shiga toxigenic Escherichia coli organisms.  StcE peptidase cleaves C1 esterase inhibitor [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.07	0.70	-5.55	15	252	2012-10-03 04:41:15	2008-02-19 13:26:58	4	13	181	1	40	186	20	293.50	42	30.59	CHANGED	EssslsYSsstWSshLPt-Wl+PGlslpF.........spsspsuclts...clGsss-Lhlpolshhhh......TpPhs....psphhc..sclscEhFQ+hPsS+Llsssasst+l-h...VhhP.cu.hhsstsPuhsshpuushR-uhu...l.sGl.NhshGIpuusG-upsuhphhushlh..AhsupGpYsss....................aGG.GGG..GhsThDtohsspFsHEhGHsaGLsH..uGpshu.....satpush.sSsWGaDus+pcFluNhhsssss...hpsCpss.......hss...cG+satpDsMpGGusspss.tsRaohassapsspIQsahcNphh	.............................................................pttlsYupphWSs.lPhsWhpPGloLpl........tcpssppGhlps......IphGussELllpsIDlGML........h...P.Rs....Rs..p...hhpp...tphtt-YFQKlPsS+LlhssYsPhHhph..........Vs.hPsGslhT..-.t....ss.uhGGWHsGsMR-ulG..KthVSoGIsNANhGIsoouGhu.p.....p....a.....shhsspIs...AHss.hGhYs..st..........l............VHGGS..G..GG......GI...VT.L.-sT..h.uN.EaSHElGHNYGLG.HassG..uo......sH.....s.sS...sWGWDu.+pRFIsNh..h.ppss....spptss.........pls.PF.Du.apahhDAMs...GGtsppsu.hsRFThapPhsu.t.hhQcahpNth...................................................	0	24	30	34
+10295	PF10463	Peptidase_U49		Peptidase U49	Rawlings N, Mistry J	anon	Manual	Family	This family contains Lit peptidase from Escherichia coli. Lit protease functions in bacterial cell death in response to infection by bacteriophage T4. Following binding of Gol peptide to domains II and III of elongation factor Tu, the Lit peptidase cleaves domain I of the elongation factor. This prevents binding of guanine nucleotides, shuts down translation and leads to cell death.	23.90	23.90	23.90	23.90	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.53	0.71	-4.54	7	29	2012-10-03 04:41:15	2008-02-21 10:51:40	4	2	29	0	11	41	4	181.90	20	57.80	CHANGED	Iphp.tsLchlWhhsahhhshhpp........l.phhcsss.phcL....................E.spshlpcupphhpahtphlpsh..psas.........ttlPpPth..ptu.p.....tss-lFLpAlualhhHEluHlhhpc.hh.......ssp.shpEEh-sDsaATpalLss.pp.s............+RtluIulAhhhlp.Lhlcpphshps..THPsspsRI.sslpt.p.pts-phh.hhs	..........................................................................h....hphhW.hs...h.hhpt........h......t..................................htht.t.h.hh....p.hp..sh....pt...............thsp.t...t.t........hssplhhhAls.allhHEluH.lhhtH.th...................................s.s.shp-EhpADpaAhchllsphtp.s.p..................hppthuIhhulhhh..lh....p.p.phshpp..oHPshppRl.s.lpt.....tp..h...........................................	0	5	8	11
+10296	PF10464	Peptidase_U40		Peptidase U40	Rawlings N, Mistry J	anon	Manual	Family	This family contains P5 murein endopeptidase from bacteriophage phi-6.  P5 murein endopeptidase has lytic activity against several gram-negative bacteria.  It is thought that the enzyme cleaves the cell wall peptide bridge formed by meso-2,6-diaminopimelic acid and D-Ala	20.80	20.80	20.90	113.30	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.37	0.70	-4.92	2	29	2009-01-15 18:05:59	2008-02-21 11:15:17	4	1	1	0	0	30	0	171.00	92	96.88	CHANGED	VQYSLRALGQKVRADGVVGSETRAALDALPENQKKAIVELQALLPKAQSVGNsRVRFTTAEVDSAVARISQKIGVPASYYQFLIPIENFVVAGGFETTVSGSFRGLGQFNRQTWDtLRRLGRNLPAFEEGSAQLNASLYAIGFLYLENKRAYEASFKGRVFTHEIAYLYHNQGAPAAEQYLTSGRLVYPKQSEAAVAAVAAARNQHVKESWA	VQYSLRALGQKVRADGVVGoETRAALDALPENQKKAIVELQALLPKAQSVGsSRVRFTsAElDSAVARISQcIGVPASYYQFLIPIENFVVAGGhETTVSGSFRGLGQFNRQTWDGLRRLGRNLPAFEEGSAQLNASLYAIGFLaLENKRAYEusFKGRVFTHEIAYLY............................................	1	0	0	0
+10297	PF10465	Inhibitor_I24	Peptidase_I24; 	PinA peptidase inhibitor 	Rawlings N, Mistry J	anon	Manual	Family	PinA inhibits the endopeptidase La.  It binds to the La homotetramer but does not interfere with the ATP binding site or the active site of La.	25.00	25.00	74.60	74.30	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.88	0.71	-4.44	2	11	2009-01-15 18:05:59	2008-02-21 15:18:23	4	1	10	0	0	10	0	139.90	77	89.06	CHANGED	ThsKWF+Is+tDptLpshaPELptGTlhKV...ltpsp-Dh.sDpGIIEl.LssGchlsIYD+shohWChWpocSl-..ElEEl...sp.Vsptshu-FpGERISYALAKLAAQENNDGYEGNLMQAAAEYIEaLEpplS	..TVDKWFRINRADpGLCNYWPELSAGTVFKVRELuKECEDDIEPDTGIIE...IELSDGKIINIYDKPITYWCLWNTESVENGEIEEVVE..RTN..QVVQKPKA-FQGERISYALAKLAAQENNDGYEGNLMQAAAEYIEWLETQIS.	0	0	0	0
+10298	PF10466	Inhibitor_I34		Saccharopepsin inhibitor I34	Mistry J	anon	Manual	Family	The saccharopepsin inhibitor is highly specific for the aspartic peptidase saccharopepsin.\	    It is largely unstructured in the absence of saccharopepsin [1], but in the presence, the inhibitor undergoes a conformation change forming an almost perfect alpha-helix from Asn2 to Met32 in the active site cleft of the peptidase.	25.00	25.00	26.10	39.40	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.43	0.72	-3.91	2	7	2009-01-15 18:05:59	2008-02-21 15:24:18	4	1	7	3	2	6	0	68.40	82	97.96	CHANGED	MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE	...MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQD.KDGKTTDADESEKHNYQEQYNKLKGAGHKKE.....	0	1	2	2
+10299	PF10467	Inhibitor_I48		Peptidase inhibitor clitocypin	Rawlings N, Mistry J	anon	Manual	Family	Clitocypin binds and inhibits cysteine proteinases.  It has no similarity to any other known cysteine proteinase inhibitors but bears some similarity to a lectin-like family of proteins from mushrooms [1].	20.60	20.60	24.10	24.50	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.89	0.71	-4.28	2	19	2009-01-15 18:05:59	2008-02-21 15:42:18	4	1	3	6	10	23	0	128.00	42	92.90	CHANGED	LEDGIYRLRAVTTHNPDPGVGGEYATVEGARRPVKAEPNTPPFFEQQIWQVTRNADGQYTIKYQGLNTPFEYGFSYDELEPNAPVIAGDPKEYILQLVPSTADVYIIRAPIQRIGVDVE.GsQtNTLsYKFFPVDGSGGDRPAWRFTRE	............GhYpLRA....sPssGlGG.YATspGspc.VpstPpoPPFFERQlWpl..T..+..s..p..-.GpYTI.p.hpshsssFt.auFSh..D.p..h..PpuPVI.su-..h.E.a.h.h..p.hP.ssspshhIpA.h.hlGhsh..sGs.p.t.pp......................................................................	0	0	10	10
+10300	PF10468	Inhibitor_I68		Carboxypeptidase inhibitor I68	Rawlings N, Mistry J	anon	Manual	Family	This is a family of tick carboxypetidase inhibitors.	25.00	25.00	29.50	29.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.31	0.72	-3.80	2	8	2009-01-15 18:05:59	2008-02-21 15:58:10	4	1	5	10	1	12	0	85.50	43	83.72	CHANGED	lVF.hhVLssupsN-CVS+GFGChPpScCP.EhRLSYsGCsTVCCDlS+LTGCcsKGGECpPh-+.C+EL.uEssSCuctQKCCVhL	..sh....LlllspupAN-CVSpGaGClPcScCPcEuRlsYu..GC..uTVCCDlS+lsuCcu+GGECpPhcpsCKE.LpupouoCs+GQKCCVal.	0	1	1	1
+10301	PF10469	AKAP7_NLS		AKAP7 2'5' RNA ligase-like domain	Buljan M, Coggill P	anon	TreeFam_TF105406	Domain	AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes [1]. AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [2]. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains Pfam:PF02834. Presumably this domain carried out some as yet unknown enzymatic function.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.40	0.70	-4.63	50	426	2012-10-03 21:31:48	2008-02-21 19:00:45	4	20	246	0	280	884	46	205.50	22	57.73	CHANGED	sTHFlulPL.spsp.lppphpchppplL....................................................................tpt.sl..pshhhsspplHlTLsshtLhspp.-lptAt.....chLppsp....pp.......................lhph......pslplpl+.Glchhss.................cVLYA..plp..t......spLpplss....plhcp.FtppGlhh.tspch...........................................phchHhTlhpspht...........................tppp...psh..sspplhccatcacFGphpl..splcLsph.hspss.sGaYcstuslpl	........................................................oHFlulsl..s......p....sp....l.p..p....ht....ph..ppplh.........................................................................tt..s.....tl......tsh.h....h.sstpLHlTls..h..h.......p.Lhspp....clppuh..............phLp.php............tp.............................................................l.p.....h.t.....pslplphp.Glphhss..........................t.s...pVLau....tst..tt..........spLp.phsp.....tltcp...F.p..t.G....lhhtcptt....................................................................................................h.p.hHhTlhpshhh............................................................tpc.....tph.....sspplhc..pa.t.s...h....a......G...p...........l...pplplsph....t.....t..............t.Y..........................................................................................	0	94	145	212
+10302	PF10470	AKAP7_RIRII_bdg		PKA-RI-RII subunit binding domain of A-kinase anchor protein	Buljan M, Coggill P	anon	TreeFam_TF105406	Domain	AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP [1]. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction [2]. The N-terminus, of family AKAP7_NLS, carries the nuclear localisation signal.	22.70	22.70	22.70	23.20	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.90	0.72	-4.14	3	57	2009-01-15 18:05:59	2008-02-21 19:01:47	4	2	29	0	22	52	1	59.70	63	33.75	CHANGED	uuEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKpQPGEGsSVKAEuuDpNGsss-NNRK	...G.uEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKp+P.G-G..SSVK.sEtu.Dp.NGsss-NNRK.......................	0	3	4	6
+10303	PF10471	APC_CDC26		Anaphase-promoting complex APC subunit 1	Buljan M, Coggill P	anon	Treefam_TF101057	Family	The anaphase-promoting complex (APC) or cyclosome is a cell cycle-regulated ubiquitin-protein ligase that regulates important events in mitosis such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins thereby targeting them for proteolysis by the 26S proteasome. CDC26 is one of the nine or so subunits identified within APC but its exact function is not known [1]. The APC/C becomes active at the metaphase/anaphase transition and remains active during G1 phase. One mechanism linked to activation of the APC/C is phosphorylation.  The yeast APC/C is composed of at least 13 subunits, but the function of many of the subunits is unknown. Hcn1 is the smallest subunit of the S. pombe APC/C, and is found to be essential for cell viability, APC/C integrity, and proper APC/C regulation. In addition, Hcn1 phosphorylation indicates a specific role for the phosphorylation of this subunit late in the cell cycle [2].	23.90	23.90	24.60	24.80	23.80	23.80	hmmbuild  --amino -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.70	0.72	-3.24	42	164	2009-01-15 18:05:59	2008-02-21 19:08:13	4	4	145	8	112	156	0	79.20	22	53.31	CHANGED	M.LRRpPTsIpLo.-.DltcaEct+pcppppppppppppp.....................tt.sttp.ssptp.lsscptphhpptspthu	....M.LRRpPTplpLph-.Dl.p-aEsh+pcpppppppppphpt.............................t...t.s.sttstspt..t..................t............................................................	0	32	51	84
+10304	PF10472	CReP_N		eIF2-alpha phosphatase phosphorylation constitutive repressor	Buljan M, Coggill P	anon	TreeFam_TF105548	Domain	This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation [1]. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus [2].	25.00	25.00	54.80	54.00	17.70	17.20	hmmbuild  -o /dev/null HMM SEED	411	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.40	0.70	-5.76	2	32	2009-01-15 18:05:59	2008-02-21 19:10:12	4	3	24	\N	15	35	0	362.50	65	55.21	CHANGED	MEsGTttuRKR.GPRhG.hFh.PFh.RRSpAsSScFPsP.u.pNsGN.....SA.PEpRspYWTKLLSQLLA.LPuLhQKlLlWSQLFGGhhPTRWLDFAusYSALRAL+GREcsAAPTsQKSLSSLpLDSS-s.VsSsLDWLEEGlpWQhSssDLcLcLKAptpALDsAA.sFLLEQQLWGVELLPSSLQutLhSpRELsSSsSGPLslQplsNFpVVSYLLNPSYLDhhPpLtlphQsSsGsuphVGFpTLTPESshLpEDtCHPQPLpAEh.ssuWptCPPLSTEGLPEIHHLRMKRLEFL.QANKGQ-LPTPDQDNGYHSLEEEHsLLRMDPpHCpDNPsQhVssAuDhP....EsTEcK.ELlhpEV.....ppSPptus..sElPhEKEstEs+hsssDhS.htt	..............Es...t.sR.....t.t.hFh.P.F.h..hpSpsssSphPsP.ustp.ts....sSs.PpsRsp.W.hKLLSQLLAPLPuLLQKlLlWSQL.FGGMhPTRWLDFAGsYusLRAL+GREcsAAPTAQ.K.SLSSLpLDs.S.-sussSPLDWLEEGlHWQCSssD......LcL-LKAKGsALDPAApAFLLEQ.QLWGVELLPuSLQu+LaSsRELGSSPSGPLNlQRlssFsVVSYLLNPSYLDChPRLElSYQNSsGsGELVsFQTLTs.ESuCLpED.tCH.PQPLsAElosASWQGCP...PLSTEGLPEIHHLRMKRLEFLQQASKGQ-LPTPDQDNGYHSLEEEHsLL.RMDsKH......C......pD..sPTQhVPsAG.slP.GssQEsTEEKIELLTpEVPLALEcpuPo.EuCPSsE....lPhEKEPGEsplSVVD.S.lc.s...........................	0	1	1	3
+10305	PF10473	CENP-F_leu_zip	Cenp-F_leu_zip;	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1	Buljan M, Coggill P	anon	TF101133	Domain	Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [1,2]. There are several leucine-rich repeats along the sequence of LEK1 that are considered to be zippers, though they do not appear to be binding DNA directly in this instance [2].	33.00	33.00	33.00	33.20	32.90	32.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.95	0.71	-4.32	30	150	2012-10-08 13:49:02	2008-02-21 19:16:05	4	14	53	0	66	118	1	136.90	33	13.97	CHANGED	DEKKpL+lhEcLKESc+cuDsL+D+VEsLERELEhSpcNpEpslL-AEsuKAElET....LKscl-phsppLpsLEhDLsslR.......SEKEsLs+pLQccQp+VSELEthsoShcsLLcEKEp-...+lQhcE-oKsAlEhLQsQL+ELsE	...........ccKpLcltpcL+cscccpssLcc.+lEsLEp-Lphupcspppshh-uEsu+tElps....Lcscl-phsppLpsLch-Lsslp.......pEK..csLsppLpccpp+lpELEphp...ss...hp..phlp...ptEpE...chphtcp.psshp.LppphpcLpE.................	0	3	7	24
+10306	PF10474	DUF2451		Protein of unknown function C-terminus (DUF2451)	Buljan M, Coggill P	anon	TreeFam_TF106152	Family	This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2450.	26.40	26.40	27.10	26.50	26.10	26.30	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.48	0.70	-4.61	12	199	2009-01-15 18:05:59	2008-02-21 19:22:53	4	8	130	0	132	188	1	211.50	37	25.45	CHANGED	LYGLppRhlAsEShhhlAcphchhcshlpphLPtpptsh.........lppFasp............slus.ls-lRchlapsssuphlslp.............shlsthsslKW-lpEs.sspHssYVDsl.p-hppFsh+Lppht.ppssls.c..h.tsLW-pslplhtchL....V-GauplKKCostGRALMpLDhpphhstLEplost+..s.chpaV-sYIKAaY....LsEp-hcpWhppp................pEYohKplsuLVptssuu......s++tRpcLLshl-s	...........................hYGLsERlVAsES.lhhlupthch.h.pshLpslhsts.pp.sh.............LppFasp................hl.ss.s.s-L+c.lahhsusph.l.chp.............................................................phl.hhusl.K.W.-l+El..hspHs.YVDhLlp..-.hpp.F.spRLtphs..ppstlsh....lpplLW-pslclsscsl....VEGau.p.V...K.KCSsEGRALM..QL..DhQphh.pL.........E...+l...s.s....h+.......shP..c......tpaV-..sYIKAYY....Ls.E.s..-.hcpWl+pH................pEYStpQlssLlshshss......p+ptRpplLthl-.........................................................................	0	56	76	109
+10307	PF10475	DUF2450		Protein of unknown function N-terminal domain (DUF2450)  	Buljan M, Coggill P	anon	TreeFam_TF106152	Family	This protein is found in eukaryotes but its function is not known. The C-terminal part of some members is DUF2451.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.85	0.70	-5.51	12	433	2012-10-03 17:31:52	2008-02-21 19:23:24	4	20	221	0	301	888	8	203.70	22	22.10	CHANGED	l-ulEtsYFpp......cFDssha.Lc+lssst..hshpp......l-cptsplppQtchluc+l.phlhppppshspthpplp-lcccLptusshCtsuR+pLstuppphTphsLtlhupp+K+psLhphL.pLsslKphpsh-hclcphlp-usYstAlplL.EspphhpsappasClp-lspplpshhthhtppLDshL.plstsF-scpYsplhpAYtLLs.+spthh-KlpphFlpslcopopsVL+shhp.t.....pscchp+hsYppLCtplsp-pah.CLhchhpsLaclhhSYaplhpa	..................................................................................................................................................................p.-+Lpp.h-hVp...hplhppI.ppppuah.puhsp.lp.pLpsp...lptu...st...tsp.......p.hR.c..p..Lpthcp..t.h...sp..s..uLp....ll.p.....pp+Rpsl.....h.t.lhp.....tLptl.p....pl......ppspsplpth...........l.....p................p.s....-.ass...A...l...p...ll.......p.sp..p..h..h....p..p..............h.t..t..h...p...s....h...p...p.....l...t...p...pl...pph....t.htp..h...........................................................................................................................................................................................................................................	2	109	163	246
+10308	PF10476	DUF2448		Protein of unknown function C-terminus (DUF2448) 	Buljan M, Coggill P	anon	TreeFam_TF106107	Family	The family DUF2349 is the N-terminal part of this family. This protein is found in eukaryotes but its function is not known.	19.60	19.60	19.60	20.30	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.39	0.71	-4.80	3	69	2009-09-10 19:42:20	2008-02-21 19:24:03	4	3	37	0	30	52	0	195.40	60	34.97	CHANGED	aRRoREADKAFlK..STuuVuoPspVILLRILAFLACAFLlAsTLYGhs-..pS.sspQTLSGGVlPPK...suNsScASDpTssuupuWQDLhGLLPE+ATEsl+lsWQaGpsHQhAVVSVGLLTCLTAlLlAGPIRLRRIDAhASVLWhLlLCLYLAEsYLpTsuPSWLDTlKFuTTSLCCLVGFAAAVATRKSTGPRRARsRRs.sst	.........+R.READQsasQ......s.SSuVKuPsQVILLRALAFLACAFLLssALYGsSc...........shss.Gus.lPPu..........GssuS.s.s.s..s.s.TssuA-GWpQLLuLLPEHssEKLpEAWAFGQSHQhuVVAlGLLTCLLAMLLAGRIRLRRIDAFuosLWALLLGLHLAEpYLpssoPSWLDTLKFSTTSLCCLVGFTAAVATRKuTGPRRaRPRRa....ss.........................	1	1	4	11
+10309	PF10477	EIF4E-T		Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E	Buljan M, Coggill P	anon	TreeFam_TF101531	Family	EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localisation signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation [2].	19.70	19.70	21.20	20.00	18.50	19.60	hmmbuild  -o /dev/null HMM SEED	578	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-13.04	0.70	-5.72	5	194	2009-01-15 18:05:59	2008-02-21 19:26:45	4	5	79	0	92	179	1	427.30	31	63.88	CHANGED	YSK-ELL-IKELP+S+cRPuCLo-KYD........................SDGVWDPEKWHuSLYPuSupSsPsEuhKK-pDs-RsoLKRRIsDPRERVK-DDLDVVLSPQR...............................................RSFGGGCpVsussuSRRssSPLE.K-s-uhRLh....................GuRRIGSGRIhs.......................................uRsFERDaRGsch-RcsEcsRDRE+-aKDKRFRR-aGDsK.........RVFu-RRRND....SYsE....EEPEWFSAGPTSQSETIELpGFDDKILEED............p+u+KRo++Ro.....pSlKEshVECNGGlu.c.c.slslspEsuADQEVPcsssLPEs.................sPG-FDFNEFFN......h.s.h...-psht.ss.usSRFS+WFp.............................................hEsttps.h..hc..t.tp.phhP..psL-psh.P+LsSh.ppsh..s.ss.h.....ht.ssspppshFpcLLs...............h.sN..sp..ph...............................hss.P..s.la.ptt..h....pph.s..s.hs..pt.htt..sshs.h..h.hhhph.shptps.slst.......t.phhs..p....p...pp.ppphhpp..sphshs.l.ph.............sS.hs.uFTPTSVlRKMhccKcKc+	.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.st.h............................................................................................................................................................................................................................................................p.......................................c..pPEWhs..Ppo..-hI-LhGF-..-.....................................................................................................s..........................................t.........................................................................p.p.....t......hp..........................................S.h...ht....................................................................................t..................t....p.............................sh.t..p.....h.......p..lp..........p......s...ts......................t..............p......h..pc.hlt...........tt.............................................................................................................................................t......................................................h........................................t.....p..............................................t....................t.t..t..pt......................................................................................................................................................................	0	26	33	65
+10311	PF10479	FSA_C		Fragile site-associated protein C-terminus	Buljan M, Coggill P	anon	TreeFam_TF105915	Domain	This is the conserved C-terminal half of the protein KIAA1109 which is the fragile site-associated protein FSA [1]. Genome-wide-association studies showed this protein to linked to the susceptibility to coeliac disease [2]. The protein may also be associated with polycystic kidney disease [3].	18.80	18.80	23.30	21.70	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	615	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-13.01	0.70	-6.45	4	151	2009-01-15 18:05:59	2008-02-21 19:31:11	4	4	85	0	95	148	0	477.70	45	20.51	CHANGED	sosSssusspQhTsWETLVlFAINascLNVQMNMuNVMGNssWhTpshpSpGRLSlGSssc+sh.hulsLGuSpLDAKGGlVGGTI-lNplchhhH..IpE-ssppPsHKhtIphhulEh+lDYMGoSVLMs+hSuhshplpDEWKssppsshssthspp...u.IhlHGDLoWDpLQlMISKSTTsDllKhhhKLpEFFoQQFKoSKRlhSsLp..PpLtspo.tAslc+Rppcp.......L..............DAtHHRHWp+sLc.ssGhhls.pLhs.LsccGshlGGohEL+GpsISLACFHG.NF+uKSWALFpL+-PsIsFsTEAph.....pSscp...lhlhQTLshpLGpsTtsQp.....ppshAsVsRlo...RN.haP.phcolpEWF...........cYuhA..NpEl-slcphPh.EsEpptso...solpRhRuuGSups..tph.thNHNpEsIFALPuLQL+FKopHlQGsssP-ht-s....KPcV.CSFlT-FpDHIhVTsDA-A.hhFLHDLloSYLpEKEKslus........Pp....hshpP..........................Gp.ssL..hpsSHospuss..........................................usSuTtsoVsupppp................DWRcFpCpTWHLEPTVRL...lSWsG+pI-PhGlDYILpKLGFpHARTTIPKWLQRGhMDPLDKV.AlhhlpLLhh	......................h..........phssWETLVlFAlNhppLsVpMNMuNVMGNssWhTpshpopGRLolsSstc+ph.huluLutSpL-u+GGlVGGsl-lst..lchh..............hH...........Ip...E..csspp........P....tHpl.tlphtuh-hRlDYMGoulLMuhhSshshplpDEW+h...s....h.sshs.s...pc...........................u.IhlcGcLpWD.hQlhIo+STTsDllKhhhKLpEFFoQQFcoS+Rs.hSoht....shl........sts...ssh..cppptpp....................................-s..tHHRHW.tlL..................thh......sshhl.s...h.h.LPp..p..u..h.........hGGohpL+GpphoLACFHG.NF+.S.KSWALFpLc-PsIsFhTEAppl.........p...psppp..........shlsQTLshpLGps.....s.............hpp...............pp..sMAsls+lo....Rp...P.thtolpEWF............................................................................pYshA..spElsh.lcp.h.sh.pt..-pthss.....s.hpthRusu...S...........................hNHppE..sIFALPphQLchKo.HhQ.tspp.Pshp.-s.........KP..pV.-CShlTEFpDH.IhVThDA-h.hhFLHDLlouYlKEK..E+s.hhs............p....hs.ps.......................................................................tp.ss.h...p.tspsphtp...................................................................................t.s.s.psh..............................................................DWRcFhC..pTWHLEPTl.R.L...lSWsG+pI-PhGVDYILpKLGFpHARTTIPKWlQRGhMDPLDKllullhhpLh..s......................................................................................................	0	39	46	75
+10312	PF10480	ICAP-1_inte_bdg		Beta-1 integrin binding protein	Buljan M, Coggill P	anon	TreeFam_TF105393	Family	ICAP-1 is a serine/threonine-rich protein that binds to the cytoplasmic domains of beta-1 integrins in a highly specific manner, binding to a NPXY sequence motif on the beta-1 integrin. The cytoplasmic domains of integrins are essential for cell adhesion, and the fact that phosphorylation of ICAP-1 by interaction with the cell-matrix implies an important role of ICAP-1 during integrin-dependent cell adhesion [1]. Overexpression of ICAP-1 strongly reduces the integrin-mediated cell spreading on extracellular matrix and inhibits both Cdc42 and Rac1. In addition, ICAP-1 induces release of Cdc42 from cellular membranes and prevents the dissociation of GDP from this GTPase [2]. An additional function of ICAP-1 is to promote differentiation of osteoprogenitors by supporting their condensation through modulating the integrin high affinity state [3],	25.00	25.00	26.20	28.40	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.30	0.71	-4.54	2	77	2012-10-04 00:02:25	2008-02-21 19:31:49	4	2	49	0	42	66	0	168.10	64	91.50	CHANGED	MFRKsKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSG..NssSDssAEFRlKYVGAIEKLphs.uKsLptPLDLINYIDsAQQDGKLPFVPs-EEhIhGVSKYGlKVuo.DQhDVLHRHsLYLIlRMlCYDDGLGAGKsLLALKTTDspppEhSlWVYQCsShEpAQAICKVLSouFDssLsSEKP	....................................................MFR.KGKKRHSS.S.SSQS.SEISTKSK..SVDSSLGGLSRSST.VA.SLDT...D..........STKSS.G..QS.NsNSDTCAEFRlKYVGAIEKLchs-uKsLEGPLDLINYIDVAQ...QDGKLPF.V.P.E..E.EhI.hGVSKYGIKVoo...sD.QaD..........VLHRHuLYLIlRMVCY..DDGLGAGKsLLALKTT..DuppEE...........hSLWVYQCsSh-QAQuICKlLusuFDslLss-..............	0	11	13	24
+10313	PF10481	CENP-F_N	Cenp-F_N;	Cenp-F N-terminal domain	Buljan M, Coggill P	anon	TreeFam_TF101133	Domain	Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore [1]. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein [2].	25.00	25.00	28.50	25.00	24.70	23.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.24	0.70	-5.05	10	64	2012-10-08 13:47:38	2008-02-22 09:02:08	4	10	40	0	34	53	0	257.70	59	11.94	CHANGED	MSWAVEEWKEGLPo+ALQKIQELEuQLDKLKKERQQRQFQL-SLEAALQKQKQKVEsEKoEuusLKRENQSLhEoCDsLEKuRQKlSHDLQVKESQVNaLEGQLNSsKKQIEKLEQELKRaKsELE....RSQpuht....su-spLsssoTPQKoFusPl.oPuphapDu+hE-LpEKYNKEVEERKRLEsElKsLQ....s.KKhsQs.lsQuTloHRDIARHQASSSVFPWQ.QEpTPS+tSusuhETPl+RssousahsWEpE-TPsKss.p.tptpt.soShtussssopLh-QLKsQNQ.EL+S+VsELEhRLQuQEK-	.......MSWAlEEWKEGLPoRALQKIQELEuQLDKLKKE+QQRQFQL-SLEAALQKQKQKVEsEKsEsssLKRENQpLhEhC-sLEKs+QKlSH-LQVKESQVNh.EGQLsSsKK.......QIE+LEQELKRhKSELE....RSQQutt....uuDspLs.ssTPQK..FsoPL.TPs.....opaE-LcEKYNKEVEERKRLEtElKsLp.....s.K+hsps.lsQuThsHRDIARHQASSSVFsWQ.QEpTPS+.Stss.cTPh+Rshuuuah.hE.EsoPs+ss.p.tptst..uuh.ssspsspLhcQLKsQNQ.......EL+u+lsELEhcLQupEK-..................................	0	7	10	18
+10314	PF10482	CtIP_N		Tumour-suppressor protein CtIP N-terminal domain	Buljan M, Coggill P	anon	TreeFam_TF106469	Domain	CtIP is predominantly a nuclear protein that complexes with both BRCA1 and the BRCA1-associated RING domain protein (BARD1). At the protein level, CtIP expression varies with cell cycle progression in a pattern identical to that of BRCA1. Thus, the steady-state levels of CtIP polypeptides, which remain low in resting cells and G1 cycling cells, increase dramatically as Dividing cells traverse the G1/S boundary. CtIP can potentially modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control [2]. This N-terminal domain carries a coiled-coil region and is essential for homodimerisation of the protein [3]. The C-terminal domain is family Pfam:PF08573.	27.00	27.00	28.00	32.70	25.90	24.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.66	0.71	-4.32	4	111	2009-01-15 18:05:59	2008-02-22 09:04:36	4	3	51	0	55	100	0	115.10	67	16.20	CHANGED	FtEhLs+LKEhHDKEl.GLQsKlscLppERChDAQRlEEhFoKNppLREQQKlLpEsI+VLEcRLRAGLCDRCsVTpEhh+KKQpEhEss+.psLphIotLpNEhpoLpEEN+pLpEELc	..Fp-hhsKLKEhH-KEVpGLQsKlscLppERh..hD..AQRL.EEhFoKNQQLREQQKsL+EoIKVLE.............c.RLRAGLCDRCsVTcEphRKKQQEFENh+pQNL+LITELh....NE+NsLQEENK+LpEpLp........................	0	2	6	17
+10315	PF10483	Elong_Iki1	Hap2_elong;	Elongator subunit Iki1	Coggill P, Eberhardt R	anon	Pfam-B_26773 (release 22.0)	Family	This family is a component of the RNA polymerase II elongator complex [1,2]. This complex is involved in elongation of RNA polymerase II transcription and in modification of wobble nucleosides in tRNA [3,4].	27.50	27.50	27.50	27.80	27.20	27.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.69	0.70	-5.04	22	253	2009-01-15 18:05:59	2008-02-22 09:11:26	4	4	198	3	176	260	0	240.80	20	82.24	CHANGED	LLp+lLSL+-.sSPLhLlLDSLtQsup.LlpEal++u.....t.pp.cllalSFEThpc..PphsspFlssp.............stshppllppltst.........stspssp..cpLlllDSlN.lhsp.......plspFlushh.sPt.......sollusaHp-.............s......ahPuslslLpalAoTllclpsh.p..hccpshcpplsc..hsht..hsss.................shslplppRRKSGRult.pahlssss+.h..hhp.........c-....................sphsp...--sEt....hTFNLshocKQ+tAREpV.LPah-AQpt.u........usGGtIlYE	.....................................................................................................phh.t......sshhL.h.Dslt..uh.llpthhp.p........t.t...lhhlu.hp.s..pp.........t.hs..htsp.........................................th.s..th.tt.hth..............................tt.sp..............thhlhlDS....ls...lhtp.............ph.phluphh..pst......................................................ss.llshhHp-l..................................a.P.t.s...hshLphlAsshlplps.......h.........t..................................................................th.hph.hR.....R+s.G......R..s..h....p..t...hhs..t...sp.......h...................tp............................................................................tt.st....psp.t........hTFNLtL..oc+p+ps+-plsLPah.upp.....................ttsutIhY-..............................................	0	54	92	137
+10316	PF10484	MRP-S23		Mitochondrial ribosomal protein S23	Buljan M, Coggill P	anon	TreeFam_TF106116	Family	MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs [1]. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system [2]. MRP-S23 is significantly up-regulated in uterine cancer cells [3].	37.50	37.50	37.80	37.70	32.20	30.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.61	0.71	-4.24	9	115	2012-10-03 14:45:55	2008-02-22 09:19:38	4	2	85	0	64	100	0	123.60	46	73.18	CHANGED	Au..SRLEKlGTIFTRVpGLL+uGAhKh--+PlWYDVYtAFPP+tEPcYsRP....sPps..sVRpIaYtEDslRAKFac.ps+uptshsLhs.spposoQpFlphYppLcspG..sh-EEh.......h.cTupsLht-tlh.p	......AtSRLEplGolF..oR.scsLlRuGslK...-KPLWaDVYpAFPPhcEPhacRP.......tsct.......sl....p...cIaYpEDtlRAK.....Fap.....hssu.c.shsLh.......ssshp.SssQ+FVc+Yp-Lpp.G..th---p.......a.-TucsLLu-thh..p.............................................	0	20	25	45
+10318	PF10486	PI3K_1B_p101	DUF2447; 	Phosphoinositide 3-kinase gamma adapter protein p101 subunit	Buljan M, Coggill P	anon	TreeFam_TF102035	Family	Class I PI3Ks are dual-specific lipid and protein kinases involved in numerous intracellular signaling pathways. Class IB PI3K, p110gamma, is mainly activated by seven-transmembrane G-protein-coupled receptors (GPCRs), through its regulatory subunit p101 and G-protein beta-gamma subunits [1].	18.20	18.20	18.80	19.60	17.40	17.20	hmmbuild  -o /dev/null HMM SEED	857	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.68	0.70	-6.97	4	166	2009-01-15 18:05:59	2008-02-22 09:24:22	4	4	47	0	94	139	0	485.90	28	92.84	CHANGED	ToCTEDRIQHALERCLHGLStss.hSopWsAGLCLNhWSLpELVsRDsGpalILlEplLt+sREsQcpspY-LlhPLALhFYasVLpAPaIP.sS-LL.KAhuhaHpFLTWPsPYCsVhpEhLoFIssEhKAPGIoYQRLVRsEQGLPs+sapSSTsTVLLlNPsEVpuEFLS...lApcLSsspps.csshspLlpHhaQAohGs+CcssuLHppLpA+slccLp-IaosssEA.EhAuu.s.-su.uREtLps+Lp-l.....uttAGh.sGshssupPs+lpPIPhPsu+CYTYSW-QDsFDlLsplLhpEspL..lps.lhu-DEEs--EE...--c.EssGpsP-RDSlhSs...h.p.ss..................S.tss..phssLu++.hp.FVSuLSsshDSGYsEDS-EuSpEhsthsp.p.ERupp+.tp....+IhpLFKoKuplshR+....Lpss.s..........stsLPLRRAGShssP..p..p.PuRu+Ro+SLPQ.thGpph.s...hst.hs..RRPFLSsD-D.....sKluThRVVVFGSDRISGKVARAYSNLRh+EospPhLTRaFKLQFaYlPVKRS...ssu.hhsP....toPSPss...ht.s.u-......EtSTNDISHYlGhLDPWYcRNVhGLMpLs.ssLC.QShKtEAE...shEsSpTphPILADMlLYYCRFATRPlLLQlYpsElTF..loG-KpTElFIpsLEL..........GHSAspRAI+ASGPGuKRLGIDGDp-slPhTLQIsYSKuslSGRSRWsslEKVCTSVsLpKACpp.EELsSphE............CLNLslTEVVKRQNSKoKKSFNQlsTSpIKlDKlQIIuppus.FslCLDQDEpKILQsVlRCEVSPCY+PEcsDhsphs+sP..sLsuQstsEhpSL....LCLPIsTFSGAlP	...................................................................................................................................................................................................h.h.........hh....thh.ph..hhh.h...hhhP.shtsh..phh....lp.E....ss..Gh...a.pc..hlhtEQtl........p.............p.p......hhlhhs....h.........h..............p.tt.....t............t.h..h..ll.p..hpsshG...th.h.tltt.Lp..........hh..h...h.p.........t.............h..h......................................................................................................................................................................................................................................................................................................................................................................................................................................................p......pttt.hh..hhphphahhPh.........................................................t..p......lu.hlu.hD.WYptsh.............t...................t.................hh.Dhh.aYhR.u...hhh.ha.hp......t......pphhh.tl..th...............................................................................................................................................................................................................................................................................................................................................................	0	9	19	49
+10319	PF10487	Nup188		Nucleoporin subcomplex protein binding to Pom34	Buljan M, Coggill P	anon	TreeFam_TF101106	Family	This is one of the many peptides that make up the nucleoporin complex (NPC), and is found across eukaryotes [1]. The Nup188 subcomplex (Nic96p-Nup188p-Nup192p-Pom152p) is one of at least six that make up the NPC, and as such is symmetrically localised on both faces of the NPC at the nuclear end, being integrally bound to the C-terminus of Pom34p [2].	25.00	25.00	29.80	25.20	24.50	20.70	hmmbuild  -o /dev/null HMM SEED	931	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.60	0.70	-6.63	4	230	2009-09-11 16:46:00	2008-02-22 09:32:58	4	8	183	0	149	233	0	642.30	25	42.33	CHANGED	cphstlspFLppsKppLLE.Lshhp.psTppu-pscs+chlAp.lLthslpspcF.upsEc.LsphLph.l.Ec.phl.chhhsl..hss.c..pthh.cLcstsahpp-Rl....stllpp...llcllophlssps.hsupshpshppL-pEla.s.cpplpsLl........................-hhhspsllaClchhp.LLpLhllNtsVssphsppWF..h.sphlt.s+LhpsTshu........t+ahshp-hs...phhlu+lpuhholloI.hLsLsouh-pup.shso..shhtDspsFchVsssLhs..-sspp.........shVLYuWShILht+.hh.pp.s...............Fs.sp.tphIphhuppA-slsVhppLpcLschLp.D....slaTslhssahhhSlshIslTupTopshtslIsssPcslIEsFlsNssapsc........lshl+uKhPLl...LhPhIpL..A.IsschAtaphccltSa..lsKhshhs..Ychhs.s.hscpso......-Llchpu.lLVhPP.hEpss.ph.hslPpuTKupIls.......................usps.ps.......LlhF.YpYNGWoLlGRlLQNL.+la....sshDs.Q+.EhhIsIIsLlsNVlsscsuV-cShhlLp.hSs.hsps.......sIlpVIaclhEp..uLpp+shcllspCsshhTsLssphsahVWsYLs+SsLL................-phGKsGLuNlIhGSIEhssG-YsFTISllKLspsLIcssLo.....s.thsp+oKpsIlspllhHLlclaEoahhW+YNpph.Q+hEIuhhLhphFpsILt.VasID.tssspsKlppl......hocAAspllshFLlss-s.shsstolhshl.s.spspohh.hGsu..spLYspslppAaslssLlIsIRsss+.LpPSsLE+hLF...sposcLlslY.ph......Po...l+lpIlcLLssLssssWssth.P.LhSaLGps.utshLcullsDLsoslpDaplthoLY.FhssllEoKQ-GLulLFLTGcssss	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....h..........................................h............lPtsThGplh..........................ssps..........llha.ap.asshshhsp.l.p..hh..p...sh................................sp.s..p....p.p.lh.ll....s..Lh.tpl............l..........p.t.....p.................s........h.......t.....p.......s.....h...........................................slhshlh.....lhpp........sl..............s...................s........lpl..lsuClphlssL..h..sh.....Ps+VWs.L.t.+os.hL.................................................ps..s.t.u.G.h..hshl.h.....s....h.E.spGcYshhluhlcLh...psLlc.s...tls......................................pp....t..........psl..........l............s....h....h.h....hh.h.-hh.shtpW+ass.t..+..plsthlhphhptl.L.hsa.....t.h...s....tt.s.....ps..plptl......................hspuu.ph.llshhh..hss.ss....thshs.............s.p..s.t...hpt......hh..phlp.shphsp.ll.p..l.p..............p..h..ss..............L.EptLh............ttu..s.t.L..ltlhshh.....................ss......h..th.p...ll....c.h.........L.ts.....l...s......s.......................................SlhuhLGs.p.u.t.t.hhpth.lsplpp....h.ps.plp...h.lhcFloshl.p..sp..hLh.hhLshp.....................................................................................................................	0	41	72	112
+10320	PF10488	PP1c_bdg		Phosphatase-1 catalytic subunit binding region	Buljan M, Coggill P	anon	TreeFam_TF105548	Domain	This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels [1].	23.90	23.90	26.10	25.30	20.60	23.20	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.00	0.70	-5.23	5	184	2009-01-15 18:05:59	2008-02-22 09:35:22	4	6	97	0	70	171	0	131.80	36	35.04	CHANGED	shPISshsuCSsc..sah.thAsc-lpoSSsspSI........Sas-EuE-uuuoSDSSphEu-hE.-sEG-+LW-shscSsDPYNPLsFTAslQTssT.sPKs.o.ptpshSspps..sSsuEuPlsSss-sSoSsDDSW-uSuDEEEst...cLWsSFCpNDDPYNPLNF+APhQoSucs.cus+hDSsosStssVuI........put+SoR+Sp+A.LlsKlpccCs+pLSsEoLSls.hptclh.s.spGs++cosKlKKV+FSPsVpVH+MssWSaAhctuRKGPWEEaARDRCRFQKRItETEcAIGYCLohpHREKMasRh	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h+...+V+F...s.....t....s.p...l+hlssWsh..uuctuR+G.sWEphAtDRsRFp+RIscsEthlusCLssptRtRhhsR......................	0	13	17	39
+10321	PF10489	RFPL3_antisense		Ret finger protein-like 3 antisense	Buljan M, Coggill P	anon	TreeFamB_TF341410	Family	This short transcript is purported to be the antisense protein of exon 2 of RFPL3 gene, however this was not confirmed. Since the RFPL3 (ret-finger protein-like 3) gene is expressed in testis the suggestion is that this may have a role in the antisense regulation of the RFPL genes. RFPL transcripts encode proteins with tripartite structure of RING finger, coiled-coil, and B30-2 domains, which are characteristic of the RING-B30 family. Each of these domains is thought to mediate protein-protein interactions by promoting homo- or heterodimerisation [1].	27.00	27.00	29.70	29.50	26.30	26.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.63	0.71	-4.34	6	31	2009-12-01 17:09:26	2008-02-22 10:15:53	4	2	5	0	4	22	0	71.80	47	51.62	CHANGED	MGNLCGCIQGDSKKPSKKRVKRKPYSTTKVTSGSTFNENTRRYAVHTNQCRRPHGSRVKKKRYPQEDDFHHTVFSNLERLDKLQPTLEASEESLVHKDRGDGERPVNVRVVQVAPLRRESRsI-	...................t...D..htsS+chspcc..Sso..pVos.soh.t.hRRYul.TpQt.R..s...+Kth.s.E........................EEs.shKctGsGER.VpsRVhps............................	0	4	4	4
+10322	PF10490	CENP-F_C_Rb_bdg	Rb-bdg_C_Cenp-F;	Rb-binding domain of kinetochore protein Cenp-F/LEK1	Buljan M, Coggill P	anon	TF101133	Domain	Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway [1,2]. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains [3].	19.20	19.20	23.40	34.30	18.60	16.10	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.44	0.72	-4.64	4	55	2012-10-08 13:53:08	2008-02-22 10:18:33	4	10	32	0	26	45	0	46.60	67	1.96	CHANGED	sp.tpspEso-aEP-GLPEVVp+GFADIPoGcsSPYILRRTThuppsSP	.....hpstEcpEso-FEPEGLPEVVKKGFADIPTGKTSPYILRRTThuTRTSP....	1	1	4	10
+10323	PF10491	Nrf1_DNA-bind		NLS-binding and DNA-binding and dimerisation domains of Nrf1	Buljan M, Coggill P	anon	TreeFam_TF105308	Family	In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].	20.30	20.30	20.30	26.00	18.40	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.48	0.70	-5.18	4	147	2009-01-15 18:05:59	2008-02-22 10:19:02	4	6	78	0	85	152	0	178.40	61	35.18	CHANGED	GPVGVAAAAAIATGKKRKRPHSFETNPSIRKRQQTRLLRKLRATIDEYsTRVGQQAlVLssoPGKPNslFKVFGAsPLENVlRNhKuhlLpDL-sALAp+AP.Ppspss.sl.ELPPLlIDGIPTsV-KMTQAQLRAFIPhMLKYSTGRGKPGWGKESsRPsWWPpDLPWANVRSDsRoE-pKpKVSWTpALRpIVhNCYKaHGREDLLPtFtEp	..................................GPVGhAAAAAlAouKKRKRPHsFEoNPSI.RKRQQsRLLRKLRsTlD.EaoTRVGQQAlVL........shoPu....K..PNssaKVFGAtPLEsVl+ph+shlh--L-sAL..AppA...P...P......ss........ELPPLsIDGIPsSV-KMTQ..AQLRAFIP.MLKY.STGRGK.PGWG+ESs+P..WWPc-.l.PWA.N..V.R..Ds...RoE-.pK..Q.+.............V.S..WTpALRpIVhNCYK.HGREDLL.sFt-p.............	0	25	31	59
+10324	PF10492	Nrf1_activ_bdg		Nrf1 activator activation site binding domain	Buljan M, Coggill P	anon	TreeFam_TF105308	Domain	In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss:Q8C4C0, there is an activation domain at 303-469, the most conserved part of which is this domain 446-469.  Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3]. The family Nrf1_DNA-bind is associated with this domain towards the N-terminal, as is the N terminal of the activation domain.	19.10	19.10	19.30	19.30	18.70	18.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.36	0.72	-3.54	7	86	2009-09-16 13:14:49	2008-02-22 10:19:52	4	5	61	0	50	83	0	60.50	45	11.56	CHANGED	othlslPV....S..MYQ....ThlA.shtQh.........lsPh.QV..........psG............................husthHthhhpussu.ts...Qhl..pVloLcs	................GlVpIPV....S..MYQ....TVVT.SlsQs..........suPV.QVAhus...lssc.u-ph.Th.............................................................s.....................................	1	12	16	30
+10325	PF10493	Rod_C		Rough deal protein C-terminal region	Buljan M,, Coggill P	anon	TreeFam_TF101176	Domain	Rod, the Rough deal protein, displays a dynamic intracellular staining pattern, localising first to kinetochores in pro-metaphase, but moving to kinetochore microtubules at metaphase. Early in anaphase the protein is once again restricted to the kinetochores, where it persists until the end of telophase. This behaviour is in all respects similar to that described for ZW10 [1], and indeed the two proteins function together, localisation of each depending upon the other [2]. These two proteins are found at the kinetochore in complex with a third, Zwilch, in both flies and humans. The C-terminus is the most conserved part of the protein. During pro-metaphase, the ZW10-Rod complex, dynein/dynactin, and Mad2 all accumulate on unattached kinetochores; microtubule capture leads to Mad2 depletion as it is carried off by dynein/dynactin; ZW10-Rod complex accumulation continues, replenishing kinetochore dynein. The continuing recruitment of the ZW10-Rod complex during metaphase may serve to maintain adequate dynein/dynactin complex on kinetochores for assisting chromatid movement during anaphase[2]. The ZW10-Rod complex acts as a bridge whose association with Zwint-1 links Mad1 and Mad2, components that are directly responsible for generating the diffusible 'wait anaphase' signal, to a structural, inner kinetochore complex containing Mis12 and KNL-1AF15q14, the last of which has been proved to be essential for kinetochore assembly in C. elegans. Removal of ZW10 or Rod inactivates the mitotic checkpoint [3].	20.30	20.30	22.00	21.40	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	551	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.84	0.70	-6.21	6	118	2009-01-15 18:05:59	2008-02-22 10:27:05	4	3	83	0	78	103	0	461.60	32	29.23	CHANGED	cGhhhP.lA+hRLPF+Lll...ppshhsILssELo.Esa.oLLLlsphhps.........shDhhhhSAsKpsh.pchK.phhcpsssppaplhs+s.sthlQoIhphlcslsssphAhhIhahlTppsP...........................-GsDplpAhhhChchAccacpslssps-A+-K....hcKlph+Y.lptTpplLhsatLNDpchL+lltpPscLIsALYcHosl.pp.......shsDIpslVpEIAclpsLslppIpshLLpKWLshhhsu.......................lhc-pshs-sss-lEsss......sltRshYlLpuashs..puVhFLlu..souLhsssshosup+pLtlhssaphh.sDsssoahcphhpcphhsLKClhaLpuLthhNI..TlppFps..osK.ullKtLWpsHuppPpulcllAplCLtYclYsPQlWNGlLp+hltFNh..................................lsaLptlL-slSuhcpLaplsuFupAWctlIptPFhoAspshS.sQpusLt+oLVhL.KCPlstsLsLlsIAchhlplshPuhA.usLLhhsps-cpcQpIKphluossspslhQQItEL.ssG.luslsptlsstl.s	.......................................................................................p....hs.huphRLPF+.lh.......tpshhp....Il....ssELs..-sh.phh.lsphhph.................shDphhhssspp....h.pphp......p...t..ptpp...sl.spp.....tthh....ps.l.phl.sl.ssp...husshhh.lspphP.............................Gs.+hpuhphChhlucc....a.h...psh......ss...p...s....cs+c..c..h...p..........hpKlch....pa....tpptTEtl..Lhsa.....t.Lss....tchLc....llspPscLIhsLYcH.sl.pp..........spshs.DIpssscEIAclp...plslpplh.hLLpKWLs..............................................................................................................hps.t.p.t.spph.php.p...cp............sLp.RlhYLLp......shshc......pthhal..h.........s...h.h..h..shp..p..ho.hsp+tRAlpsLhh..ls.sp-..........slpoh.........h.........cp..shpclp.hLKClh....aLsphEhLslsh.oh-hFps..ssKpuhlKu.LW+s..a.uc.psh....ulcLlspLCL-YclaD.pl.WNulLp..+lltFsM..................................l.shLpplLp.slo.sh.pLhpl.s..hspuWppllphPhhsAs.s.s.pQ.tth..cshlhl.tCPl..sLshhthApphhphphsthA.usLh.hspspcpppplpthlt.p....lhpQl.-h.phG.lshh.p.h......................................................................................	1	24	30	55
+10326	PF10494	Stk19		Serine-threonine protein kinase 19	Buljan M, Coggill P	anon	TreeFam_TF105332	Family	This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP [1].	21.00	21.00	21.00	21.60	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.77	0.70	-4.98	22	201	2009-01-15 18:05:59	2008-02-22 10:40:10	4	3	164	0	134	203	0	230.00	26	72.35	CHANGED	h+sshhcplsh.hsshs.pphspllphRps.lPs.llshsplau.....lh..pssThV-+pl.pLl+pGtlR+hhlss..............tthhhhhcshctllppsshlps...................hp..................................c+Flphlpppssshhhs....pphFsttp............hstLlpsGh.Ls..........................sthssss...............................a.lSlPssGsal+LlsuGRpaLlshLp+...s+a+Ehh.spLpc+W.Ghs.........................+hp.hYGhshcWhLp-slGAGllElFsT.slG.uhRh	....................................h.............tshp.hh.h..hthhps.lPP..llhhuplau............ll..ps.ThV-RpltpLhcpGtlRhhtlst...........................th.Dhcsllh.ppshhpp..........................hhp................................................................h..........pcFhphlh.s..s.t..s.shs......pphhotpp.........................lstLlpAGh.Lsh...........................................p..csts......................................................................ahlulPshG.al+hhspGRptllshlp+...s+a+Eh.hs.LhpR...............................+h.thhtlshpahlc-hlGuull-shpT.ssGhhlRh......................	1	37	71	105
+10327	PF10495	PACT_coil_coil		Pericentrin-AKAP-450 domain of centrosomal targeting protein	Buljan M, Coggill P	anon	TF105408	Domain	This domain is a coiled-coil region close to the C-terminus of centrosomal proteins that is directly responsible for recruiting AKAP-450 and pericentrin to the centrosome. Hence the suggested name for this region is a PACT domain (pericentrin-AKAP-450 centrosomal targeting). This domain is also present at the C-terminus of coiled-coil proteins from Drosophila and S. pombe, and that from the Drosophila protein is sufficient for targeting to the centrosome in mammalian cells. The function of these proteins is unknown but they seem good candidates for having a centrosomal or spindle pole body location. The final 22 residues of this domain in AKAP-450 appear specifically to be a calmodulin-binding domain indicating that this member at least is likely to contribute to centrosome assembly [1].	25.00	25.00	25.50	27.30	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.47	0.72	-4.05	18	211	2009-01-15 18:05:59	2008-02-22 11:00:32	4	5	142	0	139	223	0	80.90	41	3.77	CHANGED	+hhRpEoFR+uLsaQK+Yl.LhlssaptCppssLphlscM............GspPs.......tphpcs+p+a+oslpsllAlhR........................M+hlsccWp	...........+YLRsESFRKALlY.QK+YLLL..hl..suaQpCEpssLphlAch.....................................Gst.Ps.......htpp.cshs+FRoAlpsslAlsR........................h+als+cWp....................................	0	33	51	93
+10328	PF10496	Syntaxin-18_N		SNARE-complex protein Syntaxin-18 N-terminus 	Buljan M, Coggill P	anon	TreeFam_TF105868	Domain	This is the conserved N-terminal of Syntaxin-18. Syntaxin-18 is found in the SNARE complex of the endoplasmic reticulum and functions in the trafficking between the ER intermediate compartment and the cis-Golgi vesicle. In particular, the N-terminal region is important for the formation of ER aggregates [1]. More specifically, syntaxin-18 is involved in endoplasmic reticulum-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER with the plasma or phagosomal membranes [2].	21.20	21.20	21.20	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.86	0.72	-4.15	33	245	2009-01-15 18:05:59	2008-02-22 11:01:51	4	3	213	0	167	252	0	81.90	26	24.35	CHANGED	sDlTslFpp.Vtpsp......pp.ss.s............tptthtph.phpDpFlKEAhclhppIspLpsaLpplRpsYlshs......tsphopspcDph	....................DlT.hF+t.Vtthc.....................ptttt.s..................tp...htps....tspssFhccAhclhspIspLcpaLhphRpsYls...h.p.h.s.htp...hoctpcs................................	0	43	84	132
+10329	PF10497	zf-4CXXC_R1		Zinc-finger domain of monoamine-oxidase A repressor R1	Buljan M, Coggill P	anon	TreeFam_TF101076	Domain	R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.76	0.72	-3.90	13	365	2009-09-11 09:20:48	2008-02-22 11:03:32	4	20	145	0	233	361	3	98.80	40	16.64	CHANGED	IYDshpGpoCHQCRQKTh............Dh+ssC.....psppC...hp..Gp.........................FCGcCLhsRYGEcscEshtssc.WhCPhCRG........ICNCS...aCR+K+GhsPTGlLh+pA+tpGasSVtcaLh	...............................................................................hYs...GpoCHQCRQ.KTh............-t+.s...C................c...s..spC....tsp.....sp..................................FCssCLhsR.YG.E.c........lccs...h.............h..s......s........s...........WhCP.CRG...........ICNCS................hCR++....c....Gh...ss...TGhhhhhsp..GatsVtthL..........................	0	60	121	173
+10330	PF10498	IFT57		Intra-flagellar transport protein 57  	Buljan M, Coggill P	anon	TreeFam_TF106156	Family	Eukaryotic cilia and flagella are specialised organelles found at the periphery of cells of diverse organisms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated [1]. This protein is known as Huntington-interacting protein-1 in humans.	40.00	40.00	45.40	49.90	39.80	39.10	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.03	0.70	-5.71	18	178	2009-01-15 18:05:59	2008-02-22 11:11:11	4	3	124	0	127	178	4	298.40	38	81.42	CHANGED	ME-Ll-KLKLLsYEccahcptp..hKPLoRaYFu....hssNPuEQFahFosLssWLhs..psG.psh-pPpEaD..DPNuTssNILs-L+shG..hss-FsPsKL+sGsGEtVshlLssLu-puLpppsF...sa++Ppasp.......-c..s-pcsh..-DDs-hhhpcl---...-sp-p--.............hhp.th.....s.tttspsptllcSplDstEWplElERVhPpL..Klpl+sDs.+DWRsHl-phpphpcslppthspspthLc+.....lps-ls.psLE+lpoREchlNsQlpphlp-.a+ptppphsphpcphpphstulpphpttLsclspcL-plKpch-E+ssshoDsuPlhplKpuls+L+pEIppMsl+IGVlp+olh	.....................................................-plh-KL+lLpY-..pphh.t..p........h+s.s+aYFs.....ssN.....suEQFahFstLssWLhp....ptG.p.hptPp.E......aD...DPN.sshspIlttL+phs..hss-FsPsKL+pGhG-tshhlLstLuppALphh.ta...pap+.s.hs........--......p.tsh...-D-sE.h.hhpcl--ph...ttpcs--............p..hhp..t.........th.ttptptppl..hpopsDst-WplElERVhPpL........KVp...l+.s...D......s..+DWRhHl-QMcphpssIpsth..pcscs.Lc+.....Lps-lscsLEKItoREKalNs..QLcphlpc.Y+shptpLupspcpappsssslscpop.Lsc....ls-cLEplKpch-E+GsshoDu.uPllpIKpuls+L+pEhhpMsl+IGllppsl..............................	0	62	73	104
+10332	PF10500	SR-25		Nuclear RNA-splicing-associated protein	Buljan M, Coggill P	anon	TreeFam_TF105478	Family	SR-25, otherwise known as ADP-ribosylation factor-like factor 6-interacting protein 4, is expressed in virtually all tissues. At the N-terminus there is a repeat of serine-arginine (SR repeat), and towards the middle of the protein there are clusters of both serines and of basic amino acids. The presence of many nuclear localisation signals strongly implies that this is a nuclear protein that may contribute to RNA splicing [1]. SR-25 is also implicated, along with heat-shock-protein-27, as a mediator in the Rac1 (GTPase ras-related C3 botulinum toxin substrate 1) signalling pathway [2].	55.00	55.00	55.50	55.40	44.10	50.70	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.98	0.70	-4.88	6	90	2009-01-15 18:05:59	2008-02-22 16:23:21	4	2	66	0	53	97	1	186.70	48	80.28	CHANGED	spS+S+SpShsc...ptpcp+c+.......pp.psppR.pptt......................pcshKKt++Rt+.........ppSSSSSSSoSsSsSppp.ppcp+K+Rtt+KpK..t+KcKKct++.cKcupcct........E.ttlscAhsts.Lchhpppst.pt.sP.............shTDEQKu+lpsh+PhTKEEY-ARQSVIR+VVDPETGRTRLIKGDGElLEEIVSKERH+EINK.............QATRGDGttFQtRs.Ghh	..............................................t.................................................................................................pt...tptpp.p..t............up.sSSo.SS..S......SoS...S...S.....sS...s......p...p..spppt+KK+t..KcK........c.K............p.c+K.cKK+....c..KKhKK+...sKc+t..........ptpt.......sc....s.h..Pssslct.hpcps..tpcp.s..sP................lhTDEQKSRlpAM+PMTKEEW-ARQSlIR+VVDPETGRTR..LI.KGDGEVLEE...I.VoKERH+EINK............................QAT+GDGhhFQh+s.sh.h.........	0	15	20	36
+10333	PF10501	Ribosomal_L50	Ribosomal_S39; 	Ribosomal subunit 39S	Buljan M, Coggill P	anon	TreeFam_TF105895	Domain	The 39S ribosomal protein appears to be a subunit of one of the larger mitochondrial 66S or 70S units [1]. Under conditions of ethanol-stress in rats the larger subunit is largely dissociated into its smaller components [2]. In E. coli, in the absence of the enzyme pseudouridine synthase (RluD) synthase, there is an accumulation of 50S and 30S subunits and the appearance of abnormal particles (62S and 39S), with concomitant loss of 70S ribosomes [2].	25.10	25.10	25.10	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.29	0.71	-4.10	30	196	2012-10-02 01:16:24	2008-02-22 16:43:46	4	3	179	0	144	199	2	108.30	23	36.59	CHANGED	pphssssplpph..l.ppstppsht...........................s.s.sahphsLsD.phKFtFlKphppphG+hlPDstlpplpTlpclhpah.......psss...cscp.sctl..ptcthshP.NVplhpct	..................................................................p..h.sspphpph..l............phhpphht.......................................s.sa.phsL.p.D.phKFphlppltpphG..HhlPsspLpph....pol............pclhsah........spss...pspphh-tl....pthsLP.Nl+lh.c.........................	0	28	59	106
+10334	PF10502	Peptidase_S26		Signal peptidase, peptidase S26 	Mistry J. Rawlings N	anon	Manual	Domain	This is a family of membrane signal serine endopeptidases which function in the processing of newly-synthesised secreted proteins.  Peptidase S26 removes the hydrophobic, N-terminal, signal peptides as proteins are translocated across membranes. The active site residues take the form of a catalytic dyad that is Ser, Lys in subfamily S26A; the Ser is the nucleophile in catalysis, and the Lys is the general base.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.88	0.71	-4.65	32	3046	2012-10-02 16:34:55	2008-02-25 12:55:21	4	13	2357	14	823	4403	991	93.00	32	34.94	CHANGED	lhhNsosShPlGLYplpshsp........hpsGclVhsssPpssAhhhA.pRGYLspGl......PLlK+VhAlsGpcVshsssh.lsl-G..lshupshtpDphGRsLPsap.tstslssGElFLhu.ssssSaDuRY..FGPl..ssSul..lGhApPlaT	.......................................................................................................s.......................................................................................................................................................................................................................................................................................................................................................................................................................................................p.......h...........h......VPtGp.Y.FhM........G.D.....N.....R..s..s....St.DS........R......Y.........a......G.....h.....V..P.cpsllG+A.h.lh.h...............................................	0	221	509	690
+10335	PF10503	Esterase_phd		Esterase PHB depolymerase	Mistry J, Fushinobu S	anon	Manual	Family	This family of proteins include acetyl xylan esterases (AXE), feruloyl esterases (FAE), and poly(3-hydroxybutyrate) (PHB) depolymerases.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.53	0.70	-5.10	2	1139	2012-10-03 11:45:05	2008-02-25 13:32:45	4	32	653	0	468	2296	946	182.10	23	48.03	CHANGED	LAYtLYlPP.....Gt.R...PhVVMLHGCpQps--FAtGTRMNhLAcchGhsVLYPEQo.RApsptCWpWac.pppptGRGEssslAuLsculsstHthDsuRVYVAGLSAGuuhAslluhpaPDhFAAVulHSG.shGpAssshoAhssMRpG.t.sPussssAhssA.....hPsllhpGDuDpsVts+NA-pLssthhphsGhusupGA.tuu.RVpptpoG	............................................................................................h....hal.P..s..................s...h....t......s...h..s..Ll.V.h.LH..G.........C.....t...t........s....u.....p....s......h.....t...p.........s......o.....t......h....s.........p.........l...A....-...p....t...s......a.l......V......l....Y...P........p....t......s............t.....t........s.......t............s..........p...........t....C.......a......s.........h........h.s..............s........s.....p.......p.....p......s.......t.......s......-.....s.............s..............h.........l......t...s.......h.....l....p.....t...l...h...p......p...a....s.........l...D.......s.s..R..V..a..ls..Gh...SuGu..hM.s..s.h..hu..s.........p..........a.......P.-......l........F....A....A.......s....u..........h....h......u...........G.....h.......s......h.....s......s.....h..................s....................................................................................................................................................................................................................................................................................................................................................................tsttsts..................................................................................................................................................	0	165	303	401
+10336	PF10504	DUF2452		Protein of unknown function (DUF2452)	Buljan M, Coggill P	anon	TreeFam_TF105992	Family	This protein is found in eukaryotes but its function is unknown.	20.70	20.70	21.50	21.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.96	0.71	-4.96	10	150	2009-01-15 18:05:59	2008-02-26 12:47:45	4	1	134	0	83	166	179	138.60	36	80.19	CHANGED	spVsLVEsNPsP.sGhplVSPYpouRhu-PhDLVsLApplQcADphI+sNACsKLTVIAEQIRaLQEQARKVLEEu+RDtDLHHAACNFsK+PGpIYaLYcR-SGQpYFSMLSPcEWGs.SCPHpFlGuY+LEHDhSWTPhE-lEcpDsclchs-+Llspss	....................................................t....................ss..sthh..s...DlltLApplppADp.hl+sssss..KLp.lIs-QlphLQpQA+clLc...-uccstcLHpusCNFhKtPGplYaLYpRp....s....GppYFShlSPcEWGs..ss.s.p..c.alGuY+LptDhSW..T..Ph-clpppptphthhpphh...s..............................	0	30	42	62
+10337	PF10505	NARG2_C		NMDA receptor-regulated gene protein 2 C-terminus	Buljan M, Coggill P, Berhardt R	anon	TreeFam_TF106272	Domain	The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2.  NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse , six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi [1]. This C-terminal domain belongs to the PD-(D/E)XK nuclease superfamily [2].	20.70	20.70	20.90	21.60	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.32	0.70	-5.16	5	96	2012-10-11 20:44:46	2008-02-26 12:56:43	4	4	76	0	65	111	1	201.00	35	25.27	CHANGED	--cS-hlsPsNuNoshpLWoLQpts-.......DaplhlRhSlsslc...cocupcslts+F..l.l.lKLEYQs-aGsEtMSKSELl+tWscphL+suohuasuRISA+TaclhLcEKLTLtsLEcpL+caYsoShsNLLoHLhphLKlLsulPsGDYLLpHus..KDKFLLslhosDspsTPsSasLH.l.pTcoussDpPuloussWlPIDPoLlsphHcEpsLLPCoFPs	.........................................................ppsphhts.pcuNhsYpLaoLp......................-lhLLVRsS......lptlc...csppccpl.pp.ph...slhlhPKlEYQssa.Gs.EsLTcSELs+hWspohL+ssspha.su+IsuhTu+lhhlEclo.ppL...ccp...lsshp...s..shhslLpcl..........LK....pL....s..uLptGs.YLLpHss...cDs.lllhKss-......p....s.o..csu....asLa....pscss.ssh.s.s..h...p.ssWlPlDPslhhshHhcptRlPCoFPs.............................................	0	20	25	43
+10338	PF10506	MCC-bdg_PDZ		PDZ domain of MCC-2 bdg protein for Usher syndrome	Buljan M, Coggill P	anon	TreeFam_TF105384	Domain	The protein has a high homology to the tumour suppressor MCC (mutated in colon cancer; or MCC1 hereafter) and was named MCC2. MCC2 protein binds the first PDZ domain of AIE-75 with its C-terminal amino acids -DTFL. A possible role of MCC2 as a tumor suppressor has been put forward. The carboxyl terminus of the predicted protein was DTFL which matched the consensus motif X-S/T-X-phi (phi: hydrophobic amino acid residue) for binding to the PDZ domain of AIE-75.	21.50	21.50	23.80	22.30	21.30	19.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.99	0.72	-4.14	7	229	2009-01-15 18:05:59	2008-02-26 13:21:28	4	6	60	0	113	229	0	64.60	36	16.56	CHANGED	ccLpuplEcLcshNchLstsLpthKtpsEphsh.lGctEupAsAL..+LALpapp+shEsashhhAlht	......c+LpuplEcLcStschLsts.E-p+ppstchshhlt+t-ushsAh.....+Lth..papp+scEh.shLhAlhE......	0	20	28	55
+10339	PF10507	DUF2453		Protein of unknown function (DUF2453)	Buljan M, Coggill P	anon	TreeFam_TF105823	Family	Some members of this family are purported to contain GAF domains but this could not be confirmed. The function is not known. It is likely to be a transmembrane protein.	25.00	25.00	25.00	25.60	23.70	23.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.34	0.72	-4.26	16	194	2009-01-15 18:05:59	2008-02-26 13:33:18	4	15	115	0	142	191	6	101.10	44	34.68	CHANGED	hsuulPFlGFGFLDNulMIlAG-hIDpslGhhLGlSTMAAAALGNllSslhGlthtshlEphsp+ls.hphPsLT.tQhc.ptsphusplGsslGlhlGClLGMhPLLFhss	.................hsulPFlGFGFlDNhIMIlAG-hI-holGhhhulSTMA..AAALGNllSDlsGlshush.lEths.p+l.......G..hph...........P....sLostQhc.....h.........hps+husphGpslGlslGClLGMhPLlFht.s..........................	0	65	83	122
+10340	PF10508	Proteasom_PSMB	Proteasom_PSMB5; 	Proteasome non-ATPase 26S subunit	Buljan M, Coggill P	anon	TreeFam_TF106231	Family	The 26S proteasome, a eukaryotic ATP-dependent, dumb-bell shaped, protease complex with a molecular mass of approx 20kDa consists of a central 20S proteasome,functioning as a catalytic machine, and two large V-shaped terminal modules, having possible regulatory roles,composed of multiple subunits of 25- 110 kDa attached to the central portion in opposite orientations. It is responsible for degradation of abnormal intracellular proteins, including oxidatively damaged proteins, and may play a role as a component of a cellular anti-oxidative system. Expression of catalytic core subunits including PSMB5 and peptidase activities of the proteasome were elevated following incubation with 3-methylcholanthrene. The 20S proteasome comprises a cylindrical stack of four rings, two outer rings formed by seven alpha-subunits (alpha1-alpha7) and two inner rings of seven beta-subunits (beta1-beta7). Two outer rings of alpha subunits maintain structure, while the central beta rings contain the proteolytic active core subunits beta1 (PSMB6), beta2 (PSMB7), and beta5 (PSMB5). Expression of PSMB5 can be altered by chemical reactants, such as 3-methylcholanthrene [1].	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.55	0.70	-6.23	9	249	2012-10-11 20:01:02	2008-02-27 11:21:59	4	12	149	0	143	379	6	365.10	21	83.06	CHANGED	htshhpchlpplpst...phh-pLsthpsslstps.hptlspth.........lassLs..os....p.-ph.lthplLcplltshsscsh...hsphpshLpcGLspssssl+thshhp....ltRhlpppsushphlsspslh.hlhhsltspchssuptAhphLsplsppphthctl.......pspLpslhpp.s-hlRhRlY-lslcluuhSssshshptp...lhcplLpElps.-DVLlphssl-llscLAp.spaGhpaLtppulh-plsshlptscpDP...hushhlsGhh.....+FastlAsh.ss.plhpsaPphhpplh...phhsstD.shhssAhDolGhlutsl-GKphL....+sssshcphltthusttp.hshch+hphLpulsslh..tppptpppl........shscsWYpphuppshp....lhhsllppPFPEl+suuhchhpslssasWslpt.hlsssGFl-alLDcpoEpsK-hc.tKapll+plsp..p....usslhucsphl....+LpcYlp.GPaahps.sssAsp..ss-	.....................................................................................................................................................................................................................l..hh..................ph.........l.hs.L..p..sp...tlp.hsh.t.......ltph....pp...t..t....s.....ht..hh.s...p......l....h...ll.hl.tt...php.l.sptA..hphltpls.t..p.t.............th.p...lh....h......htpLtpl.h.tp...ss....h.h.R.......h.R..lhp................l....lspl.sphS.......p...h.p.hhhp.t..s..l..ls.llp....plps..cDhLl...p...hssh-hlspL.u....ppps............h....pal...p.p.slhptl....sshl.t..ptss.............tt.hhl..uhh.........................................t..h.............h..h.......h.............h.......h................s..........u.hp.shu...h.s.ts..puh.hl...........h...h..h....t.........t...hpshs.h.........................................................hht.ht......................h.t.....pps..-hp.s.hthh..h.........h............h.......t........t.hhphhhs.t.t...............h+hthh..h..............................h..........thp.hht.G.a................................................................................................................................................	1	59	77	114
+10341	PF10509	GalKase_gal_bdg		Galactokinase galactose-binding signature	Finn R, Coggill P	anon	PROSITE_PS00106, Pfam-B_2277 (release 22.0)	Domain	This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry [1]. The function of this domain appears to be to bind galactose [2], and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6 [3]. This domain is associated with the families GHMP_kinases_C, Pfam:PF08544 and GHMP_kinases_N, Pfam:PF00288.	20.20	20.20	20.20	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.79	0.72	-4.69	183	3091	2009-01-15 18:05:59	2008-02-27 17:35:22	4	16	2627	25	790	2189	438	51.10	45	12.61	CHANGED	tptFpptF....upp..sp..h.hhpAPGRVNLIGEHTDYNsGhVLPhAIshsshsu.sphp	..................p.phFtphF.....G.t......ss......h.shtAPG.......RVNLI.......G.EHTDYNsGaVlPsAI.shsThsust.R............	0	262	473	658
+10342	PF10510	PIG-S		Phosphatidylinositol-glycan biosynthesis class S protein	Buljan M, Coggill P	anon	TreeFam_TF105857	Family	PIG-S is one of several key, core, components of the glycosylphosphatidylinositol (GPI) trans-amidase complex that mediates GPI anchoring in the endoplasmic reticulum. Anchoring occurs when a protein's C-terminal GPI attachment signal peptide is replaced with a pre-assembled GPI [1]. Mammalian GPITransamidase consists of at least five components: Gaa1, Gpi8, PIG-S, PIG-T, and PIG-U, all five of which are required for function. It is possible that Gaa1, Gpi8, PIG-S, and PIG-T form a tightly associated core that is only weakly associated with PIG-U.  The exact function of PIG-S is unclear [2].	20.40	20.40	21.50	20.60	19.30	20.30	hmmbuild  -o /dev/null HMM SEED	517	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.50	0.70	-5.83	32	374	2009-09-10 22:53:53	2008-02-27 17:48:41	4	11	269	0	266	360	2	405.30	24	84.23	CHANGED	luahhl..hlhl.......................GlPlWa+TTol...YRAsLPhpplpshspth.........................psplphslslhlpssp...........h.ssttcpl.pplpctlss.....p...t.taplplphhpts.pppppht....t.........................h..tt..th.phphp.tspph.lhhspssl..sp.....lsthlushLh...........tplhptchtplsplhsstshttsp........................................ulpaussYcl.sFSLLssssp..shs..WDI-........sulcc.YhpPllptLuslsNFol-oQl.Yaushs...hpshhspt.t............................................................................................................aslsps-LuphINssEhsLsss...hspsPs............lNFllYl.......Pss..ppuPlhlppps..............ssuFllPQWGGVhlhN.s..........tpp.sh.......lscptLtssh.sFspQLhpLLGlspsss.......................ssshcl-sLhRhpshpsltpussTLtSLs+LscslspIsIPcpVtspVpp..ulptlpp.uhctLpts.......phppALthuppAhshuE+AFF-t.sMltQhYFPsEHKhAVYlPLhuPlslsllhull+.hKchppcp+p	.................................................................................................................................................................hhhlhhhlGlPhWapoTph...aRs.LPhpth.tht...................................h....h.l.l...t...................tptl...t..h.p.hp.....................hphph...........t...............................................................t.....t........h...hhhs...tt.....t...............ls.hhtt.lh..........................hht....th.h..hh...s.t...t.....................................................................hsht.s.thcl.shoLhssssp.....p...W-lp...................t.slpp.alpPhlp..tlusls..NF.o....lcoQl.has.hs.......hpsp.........t............................................................................................................hh.l...p..psLsth...l.ss...sE.h..Lsss..........hs.ts.s.................................................................lpallal..........P.....tpsPlhlt....ttp........................ssuah.P......pWGulhlhN.s................tt..h.................hsp.th....hh.hFh.s..pLh.Lh...Ghsps........................................h.hclstlhhhpshp.lhpussTLtSLspLh.tpls..phsI.ppluppV.p.......ulttlpt.shp.ltts..........................................htpuh.h.up.A.t.uEpAFF-..ohlt.hYFPp-pKhAlYlPLhhPhslsllhuhhp.hhth................................................................................................	0	103	157	222
+10343	PF10511	Cementoin		Trappin protein transglutaminase binding domain	Finn R, Coggill P	anon	PROSITE_PS00313	Family	Trappin-2, itself a protease inhibitor, has this unique N-terminal domain that enables it to become cross-linked to extracellular matrix proteins by transglutaminase [1]. This domain contains several repeated motifs with the the consensus sequence Gly-Gln-Asp-Pro-Val-Lys, and these together can anchor the whole molecule to extracellular matrix proteins, such as laminin, fibronectin, beta-crystallin, collagen IV, fibrinogen, and elastin, by transglutaminase-catalysed cross-links. The whole domain is rich in glutamine and lysine, thus allowing and transglutaminase(s) to catalyse the formation of an intermolecular epsilon-(gamma-glutamyl)lysine isopeptide bond [2]. Cementoin is associated with the WAP family, Pfam:PF00095, at the C-terminus.	22.30	22.30	22.30	22.30	21.40	22.10	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.26	0.73	-6.52	0.73	-3.99	21	190	2009-01-15 18:05:59	2008-02-28 13:12:49	4	14	25	1	41	164	0	16.90	61	22.81	CHANGED	GQDsVKGph.lKGQDss	.GQDsVKGpsPVKGQDss...	0	2	2	2
+10344	PF10512	Borealin		Cell division cycle-associated protein 8 	Buljan M, Coggill P	anon	TreeFam_TF101077	Family	The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Borealin is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed with INCENP, Borealin, and Survivin. Depletion of Borealin by RNA interference delays mitotic progression and results in kinetochore-spindle mis-attachments and an increase in bipolar spindles associated with ectopic asters [1].	19.50	19.50	19.70	23.70	19.00	19.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.66	0.71	-4.17	9	119	2009-01-15 18:05:59	2008-02-28 14:20:31	4	3	68	2	73	116	0	115.60	33	42.21	CHANGED	RhSRuphtTPhsup...htsShs+.hshhTP.......+hsspss.hshLRpsphuEslYSho..GSPl.Ass...c.hslslPItsG....cshcL.As-l-oh.lppLDscsLppIKpLpspLspIssphc	................................................S+tthhTPtssp........thS.hs.p.psh...hTP...............+hs..sps..tts.h.L.R...pPtsuEhlhohu..GSPL.sss...............cph.lslPlssG.....csh+L...ss.-.lpph...slt..pLDs....csLspIKpLpspLtplss.h.................................	0	17	20	49
+10345	PF10513	EPL1		Enhancer of polycomb-like	Mistry J, Wood V	anon	Pfam-B_3033 (release 22.0)	Family	This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes [3].	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.34	0.71	-3.99	83	1066	2009-01-15 18:05:59	2008-02-28 14:26:12	4	25	277	0	649	973	5	150.90	23	16.50	CHANGED	hRh++lshp....ptl.lhp..t.c-l.shpt..............................................................................t.t..p.............p..ptplpthhstsp..........................................lPpPshp....hp...hpp.hsst.atpPp.sYl+ap.................................s--hs................tscYDhD-cDptWLcph...........................Npc...............t.shp.................lopppFEhlh-chE+p	......................................................................................................................................................................................................................................................................t....th.s......p.h.lhp....p-h.s.....................................................................................h..tp.......................t..ccp.hptshpttp..........................................................................................................................................lPpPphc...........lp.......hpp..ss....a.p..Pp..pa.h.+ht...ttt................................................st-hs............................tscYDhD-cD...ttW.Lc.h.h..............................................................................Npc.................................................t.h...t................................................lstppFEhlh-clE+...........................................................................................................................................................	0	168	282	466
+10346	PF10514	Bcl-2_BAD		Pro-apoptotic Bcl-2 protein, BAD	Buljan M, Coggill P	anon	TreeFam_TF102001	Family	BAD is a Bcl-2 homology domain 3 (BH3)-only pro-apoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors [1]. Binding of BAD to mitochondria is thought to be exclusively mediated by its BH3 domain. Membrane localisation of BAD mediates membrane translocation of Bcl-XL. The C-terminal part of BAD is sufficient for membrane binding. There are two segments with differing lipid-binding preferences, LBD1 and LBD2, that are responsible for this binding: (i) LBD1 located in the proximity of the BH3 domain (amino acids 122-131) and (ii) LBD2, the putative C-terminal alpha-helix-5 [2]. Phosphorylation-regulated 14-3-3 protein binding may expose the cholesterol-preferring LBD1 and bury the LBD2, thereby mediating translocation of BAD to raft-like micro-domains [3].	25.00	25.00	35.70	35.70	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.06	0.71	-4.29	4	66	2009-01-15 18:05:59	2008-02-28 16:01:59	4	2	34	2	24	48	0	140.30	56	92.03	CHANGED	MFQIPEFE.SEQEDuSpsDRGLGPS.oGDtP.G.tKpahpAPGLLtphspQQ.GQssusSHHGGsGshEhRSRHSSY.AGsE-DEtM.tE-.uPFRGRSRSAPPNLWAAQRYGRELRRMSDEFcsSF.KGLPRPKSAGTATQMRQSsSWTRhlQSWWsRNLG+GuSsPSQ	.........................................................................MFQIs-.-.oEpEDs........SsspRuLuPp.ststs.u.....htsPuhhhtssHpQ.tp..ssupsH+G.Gs.ushEhR..SRH..S.......Sh.uG..s--....DEuh.tEE.uPFRGRSRSAPPNLWAApRYGRELRRMSDEFpsSF.K.G.LP.RPKSAGTAoQMcQSsSWp+hh.uhasRp.ucGtstPs..............................	0	1	4	9
+10347	PF10515	APP_amyloid		beta-amyloid precursor protein C-terminus	Finn R, Coggill P	anon	PROSITE_PS00320, Pfam-B_2082 (release 22.0)	Family	This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, Pfam:PF02177, further towards the N-terminus.	19.90	19.90	20.50	20.20	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.50	0.72	-3.71	9	380	2009-01-15 18:05:59	2008-02-28 17:07:07	4	21	99	18	118	341	0	51.60	67	8.22	CHANGED	lIllullhl+.R+shusluHGhVEVDss....hoP...EE++LscMQppGYENPTYKaaE	.............................................................VIVIoLVML+.K+Q...Yso.I.pHGlVE.VDsh....lTP......EERHLsKMQppGYENPTYKahE........	0	21	30	66
+10348	PF10516	SHNi-TPR		SHNi-TPR	Mistry J, Wood V	anon	Pfam-B_14727 (release 22.0)	Repeat	SHNi-TPR family members contain a reiterated sequence motif that is an interrupted form of TPR repeat [1].	20.70	20.70	20.70	20.80	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.33	0.72	-4.71	25	326	2012-10-11 20:01:02	2008-02-29 10:58:00	4	17	229	0	195	330	10	37.60	37	7.83	CHANGED	A-sashLGElSLEsEpFsQAspDhcpuLpL+pplhssc	..........Apsa.tLGElSlEuEpaspAlpDappsLslppphh.sc..........	1	65	104	158
+10349	PF10517	DM13		Electron transfer DM13	Iyer L, Mistry J	anon	Manual	Domain	The DM13 domain is a component of a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins [1].  It contains a nearly absolutely conserved cysteine, which could be involved in a redox reaction, either as a naked thiol group or through binding a prosthetic group like heme [1].	25.00	25.00	25.60	26.40	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.33	0.72	-3.67	66	749	2009-01-15 18:05:59	2008-02-29 15:11:02	4	14	535	0	284	582	71	101.70	27	42.30	CHANGED	G....pFpt..pss...HhspGplpl....supphlthp.shss...G...PDh+laLuss......tsptsh.h.psph..lplGsl.Ksa..sshhhslPsslclscassVllWC-pFu.hhuuAphp	.........................pFpt..pss.....ct.s.p.G.pspl..........hsucp.hlh.t.sacupt.G...PDhalaLsps........................sshcpt..........tclu....l....ct....ppc..shsLPps.l...c.l..sc..aspVslaCcchps..FGuApl.....	0	108	166	254
+10350	PF10518	TAT_signal		TAT (twin-arginine translocation) pathway signal sequence	Bateman A	anon	Bateman A	Motif	\N	19.90	19.90	19.90	19.90	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.85	0.74	-7.47	0.74	-3.49	64	1505	2012-10-02 00:19:25	2008-02-29 15:28:33	4	168	868	0	484	1326	535	25.60	34	5.54	CHANGED	phoRRshL+uuuusuussshuussss	....loRRsFLKuuuusuAusuluush.............	0	160	342	422
+10352	PF10520	Kua-UEV1_localn		Kua-ubiquitin conjugating enzyme hybrid localisation domain	Buljan M, Coggill P	anon	TreeFam_TF106147	Domain	This domain is part of the transcript of the fusion of two genes, the UEV1, an enzymatically inactive variant of the E2 ubiquitin-conjugating enzymes that regulate non-canonical elongation of ubiquitin chains, and Kua, an otherwise unknown gene. UEV1A is a nuclear protein, whereas both Kua and Kua-UEV localise to cytoplasmic structures, indicating that the addition of a Kua domain to UEV confers new biological properties. UEV1-Kua carries the B domain with its characteristic double histidine motif, and it is probably this domain which determines the cytoplasmic localisation. It is postulated that this hybrid transcript could preferentially direct the variant polyubiquitination of substrates closely associated with the cytoplasmic face of the endoplasmic reticulum, possibly, although not necessarily, in conjunction with membrane-bound ubiquitin-conjugating enzymes [1].	21.70	21.70	24.30	23.40	20.30	19.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.44	0.71	-4.62	21	202	2009-01-15 18:05:59	2008-02-29 16:08:18	4	3	148	0	125	190	17	167.40	46	60.55	CHANGED	hlhADFsSGlsHWusDTWGos-pPllGp.aIcsFREHHlcPpsIT+HDFlEsNussshsplssLhhhshphhhpsss.....h.......shps...FlhshshalshTNQlHKWSHthhu.lPshVhhLQchcllLsR+cH+hHHpuPa-shYCIToGWLNhsL-clsFW+phEtllphhTGhpPRucD	.....................................lhADFhSGlVHW......uuD...TWGSs-hPllGcsFIRsFREHHlDPouI...TRH....D.FIETNGDNs.....hlslhsLhhhsaphhstss.t....th...h..............shps.Flhshh.lalshTN........QIHKWSHohhu..LPtaVhhLQch+lILPR+HH.R.lHHluPH-oYaCI..T...TGWlNhsL-....ph....tFapthE.llphhTG.pPRspD..................	1	45	66	98
+10353	PF10521	DUF2454		Protein of unknown function (DUF2454)	Mistry J, Wood V	anon	Pfam-B_82729 (release 22.0)	Family	A Schizosaccharomyces pombe member of this family is known to interact with Tel2.  Tel2 is a component of the TOR complexes [1].	22.30	22.30	22.30	22.60	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.79	0.70	-5.40	29	199	2009-01-15 18:05:59	2008-02-29 16:15:39	4	5	178	0	142	207	0	256.50	20	52.36	CHANGED	cllhsLusasss...ppshooppspshsptllp...............sss.hphlpp..........hLhppl+Phhh+s............p..thottG+.............shpP..h.tht.s......t.psWKhssshtshslsWhlh..pthspspls....sphshllPslLsLlDDp...ssshKhpGspLLpplLp.h.psp.........LppTsLssVap-ulhspLh.lPshostspolpLlpssaPsLhsLh.h.......................tsspsp.......phtplschlpcsILsshtthps...............a.pLsphLlppl.thltp.LGhpsstaLpcll.hltp.hlpsPhhsth	........................................................................................h..h.has.....p.sWs...o.ts..tphsttlhp...................pt..tt...htp...........hlhthl+Phh.+p.......................t...............................t..............psWKpps..sht.t.shtWslt..............psspshls.......................pph.hllPs.hLsllDDh...psphKhtGlphLpplltps.tsp........................LtppshspVh.culh.s.pLh........spshpLlphshsslhsLh.h...................................psstt.........c.pphschltphlLss.hthttp...................tlpph.hhpp.ls.hlpp..lGl.hss+aLpclh.hl.t.hlps..h...................................................................	0	37	72	109
+10354	PF10522	RII_binding_1		RII binding domain	Bateman A	anon	Vijayaraghavan et al. Mol Endocrinology 13(5):705-717 (1999)	Motif	This domain is found is a wide variety of AKAPs (A kinase anchoring proteins) [1].	14.40	14.40	14.40	14.40	14.30	14.30	hmmbuild  -o /dev/null HMM SEED	18	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.55	0.76	-6.60	0.76	-2.98	14	161	2009-01-15 18:05:59	2008-03-03 10:00:48	4	11	27	0	47	185	0	18.00	44	1.91	CHANGED	plcphAsplVptVIppAh	.pLEatAspLlptlIQpAh...	2	4	4	9
+10355	PF10523	BEN		BEN domain	Lakshminarayan I, Bateman A	anon	Lakshminarayan I	Domain	The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription [1].	21.30	21.30	21.40	21.60	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.34	0.72	-3.92	70	842	2009-01-15 18:05:59	2008-03-03 10:50:14	4	14	114	0	412	780	0	78.60	21	21.22	CHANGED	pphsptLlptlFscphhsp..shssphp..................t.sp..tLDsptlphI+phlppthshpp.......phWt.pshptls..phhpstpppt	........t.phsppLLthlFscph.hssp.shsGphpp................ttss+p.tLDspclphl+.....palpthhsspc............p.a..phtppls..phhpp..p..h.....................................	0	71	102	212
+10356	PF10524	NfI_DNAbd_pre-N		Nuclear factor I protein pre-N-terminus	Finn R, Coggill P	anon	PROSITE_PS00349	Family	The Nuclear factor I (NFI) family of site-specific DNA-binding proteins (also known as CTF or CAAT box transcription factor) functions both in viral DNA replication and in the regulation of gene expression in higher organisms. The N-terminal 200 residues contains the DNA-binding and dimerisation domain, but also has an 8-47 residue highly conserved region 5' of this, whose function is not known. Deletion of the N-terminal 200 amino acids removes the DNA-binding activity, dimerisation-ability and the stimulation of adenovirus DNA replication [1].	21.50	21.50	22.20	22.90	20.80	19.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.18	0.72	-4.36	7	412	2009-01-15 18:05:59	2008-03-03 11:18:10	4	5	78	0	136	328	0	42.20	88	9.29	CHANGED	sh...pQ--htPFlEtLLPaV+A.AYsWFpLQAAKR+aaKcH-K	.....s...shhQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEK...	0	19	35	75
+10357	PF10525	Engrail_1_C_sig		Engrailed homeobox C-terminal signature domain	Finn R, Coggill P	anon	PROSITE_PS00033, Pfam-B_11539 (release 22.0)	Domain	Engrailed homeobox proteins are characterised by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. This domain of approximately 20 residues forms a kind of a signature pattern for this subfamily of proteins [1].	21.70	21.70	22.50	21.70	19.90	21.60	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.13	0.72	-7.54	0.72	-4.82	23	236	2009-01-15 18:05:59	2008-03-03 14:14:06	4	1	120	2	106	226	0	30.00	64	10.64	CHANGED	AoGs+NsLALpLMAQGLYNHST.sshsccp-sp	....AoGtKNsLALpLMAQGLYNHST.sshppcp-p...............	0	27	36	68
+10360	PF10528	PA14_2		GLEYA domain	Linder T, Bateman A	anon	Linder T	Domain	This presumed domain is found in fungal adhesins and is related to the PA14 domain.	19.70	19.70	19.70	20.20	19.50	18.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.37	0.71	-4.11	8	132	2012-10-02 01:24:23	2008-03-03 17:31:24	4	25	47	1	112	246	18	116.20	24	15.87	CHANGED	shsIVaQhahhs.tT.sTYTLsV.sNsDDlFaGWFGs.KAhSGWSss.......NYDsYAhWp.......GppuhushssssLssGpalPlRFlhANGuuhGuFsFsFsussosslssT........oYsY...TuTC	......................hsl.hp.GYFhsspo.GsYoFsl........p..sDD...hshlhh.Gs......sA......as.s.....hs.ps......................Nhsh..hsh..h.........ssss..s..p.s..sh..shpL..puGhYYPlRl.ha.sNt.s.ssushsh.shpsP.sGshhhs......................t...................................	0	18	59	104
+10361	PF10529	Hist_rich_Ca-bd		Histidine-rich Calcium-binding repeat region	Finn R, Coggill P	anon	PROSITE_PS00328	Repeat	This is a histidine-rich calcium binding repeat which appears in proteins called histidine-rich-calcium binding proteins (HRC). HRC is a high capacity, low affinity Ca2+-binding protein, residing in the lumen of the sarcoplasmic reticulum. HRC binds directly to triadin. This binding interaction occurs between the histidine-rich region of HRC and multiple clusters of charged amino acids, named as the KEKE motifs, in the lumenal domain of triadin. The region in which this repeat is found in many copies is long and variable but is the acidic region of the protein. There is also a cysteine-rich region further towards the C-terminus [1]. HRC may regulate sarcoplasmic reticular calcium transport and play a critical role in maintaining calcium homeostasis and function in the heart. HRC as a candidate regulator of sarcoplasmic reticular calcium uptake [2].	17.50	9.00	17.50	9.10	17.40	8.90	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.44	0.73	-6.52	0.73	-3.76	25	173	2009-01-15 18:05:59	2008-03-04 12:26:43	4	10	17	0	51	157	0	15.30	56	11.48	CHANGED	HRH..RGHc-E-D-D-D	.....HRH..pGHccEED-Dss.....	0	6	6	6
+10362	PF10530	Toxin_35		Toxin with inhibitor cystine knot ICK or Knottin scaffold	Finn R, Coggill P	anon	PROSITE_PS60029	Family	Spider toxins of the CSTX family are ion channel toxins containing an inhibitor cystine knot (ICK) structural motif or Knottin scaffold. The four disulfide bonds present in the CSTX spider toxin family are arranged in the following pattern: 1-4, 2-5, 3-8 and 6-7. CSTX-1 is the most important component of C. salei venom in terms of relative abundance and toxicity and therefore is likely to contribute significantly to the overall toxicity of the whole venom. CSTX-1 blocked rat neuronal L-type, but no other types of HVA Cav channels [3]. Interestingly, the omega-toxins from Phoneutria nigriventer venom (another South American species also belonging to the Ctenidae family) are included as they carry the same disulfide bond arrangement. suggested that CSTX-1 may interact with Cav channels. Calcium ion voltage channel heteromultimer containing an L-type pore-forming alpha1-subunit is the most probable candidate for the molecular target of CSTX-1 these toxins [3].	25.00	25.00	27.80	30.10	20.60	24.70	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.80	0.72	-6.97	0.72	-3.86	6	67	2009-09-11 14:32:54	2008-03-04 12:49:05	4	1	6	0	0	71	0	26.30	76	26.11	CHANGED	CIs++cSCppD.++GCC....ahhoCsC	CIPKHHECTSN.KHGCCRGshFKYKCQC	0	0	0	0
+10363	PF10531	SLBB		SLBB domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	\N	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.64	0.72	-4.08	139	11758	2012-10-03 10:59:06	2008-03-04 15:21:41	4	110	4407	39	3040	9399	3756	52.50	24	14.22	CHANGED	hlslsGp.Vpc.....Pushclth..Gsslp-llph..uGGhstp.ut.......t..........sGshhshs	.......................htlsGc.Vpp......P.G.h.h.plsh......G.......h.........s...lt..-hlpt...AG.Ghsps..up..............p...............st......h..............................	0	1080	2052	2579
+10364	PF10532	Plant_all_beta		Plant specific N-all beta domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Babu and colleagues [1]. It is found associated with the WRKY domain Pfam:PF03106.	21.60	21.60	22.00	33.00	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.35	0.71	-4.01	10	22	2009-01-15 18:05:59	2008-03-05 11:41:14	4	4	3	0	1	22	0	105.40	36	16.50	CHANGED	pKlulDEossKLKLSYhsh.spsp..REsYIsDDEDVhlYLTss-pEuhRsVLHVEllsc.t.s-ch.EQlshV-R+..SSlGpNasplsstsc-h..csssshhhsE.......ssEsllEs-sp	........pKlulDEsshKL+LSY....spsc..REsYIsDDEDVhlaLTpscpcuhhsVLHVE.lst.t.sEch.EplShs-t+..SSVGhNhtc.ss.p-.h..c.stshh.s-.......tsEsllt.c.......................	0	0	0	0
+10365	PF10533	Plant_zn_clust		Plant zinc cluster domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This zinc binding domain was identified by Babu and colleagues and found associated with the WRKY domain Pfam:PF03106 [1].	20.60	20.60	20.90	20.70	16.40	20.10	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.76	0.72	-4.32	21	226	2009-01-15 18:05:59	2008-03-05 11:44:15	4	2	43	0	90	230	0	45.10	53	14.48	CHANGED	+++Csttspsputt....suuuu+CHCSK+.RKt..RlKRslRVPAISuKlAD	................+++Cpst.spstsp.........suuuG+CHC..S.K+..R......K...Rl...KRoIRVPAISs.KlAD........	0	11	54	73
+10366	PF10534	CRIC_ras_sig		Connector enhancer of kinase suppressor of ras	Finn R, Coggill P	anon	PROSITE_PS51290	Domain	The CRIC - Connector enhancer of kinase suppressor of ras - domain functions as a scaffold in several signal cascades and acts on proliferation, differentiation and apoptosis.	22.00	22.00	22.90	22.30	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.04	0.72	-3.93	9	212	2009-01-15 18:05:59	2008-03-05 11:48:43	4	14	49	1	128	176	0	92.00	52	12.49	CHANGED	sL+oLspKLpAus+sLQshIpuRh+ssu.-utsopchPschLsuVV-LItAA+uLLuWLsRh.FotloDaoss+.cIhpLChELsssVpccssss	.........................NL+oLscKLpAuu+NLQNaI..suRR+...ustYD.G....psS..+..Kh....PNDFLTSVV-LIuAAKuLLA....WLDRsPFsulsD.aSlo+NpllQLCLELTTlVQpDCsV........	0	10	17	69
+10368	PF10536	PMD		Plant mobile domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Babu and colleagues in a variety of transposases [1].	24.00	24.00	24.10	24.00	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.50	0.70	-5.46	44	1219	2009-01-15 18:05:59	2008-03-05 12:39:04	4	78	27	0	764	1162	0	222.00	17	35.00	CHANGED	uhuhhtsls....t..phphDps..LlsuLs-+WpsETpTFhhPhGEhTlTLpDVshLhGLsltGp......sVsushssp....hpch.......htchhthp.t.....................................................tphpppss.phs.Wlpphh....thssp.....................hpptAFLlhhluthlFss...pssptlshthh.slstslsp.....ssphuhGsAsLAhLYppLs....pustps............ssslsGshh...LlQlW...saERhthh....RP...............................p.t...h..............................................ps..............Ph..........sthWps...p.....psps.............hppth.........-t.p.sph.WpPY......spshttt....hhst.s.....................ppth......shhp..pss..L.l.............sh.......s......tlEhahPpRVhRQ.FGhtQs.lP......hph......hphhtp...tshtsastphtsh...h..t.tts..sp...........stYhcWatp	............................................................................................................................................................................................hs.....sh.-h..lhth......................................................................................................................................................................................................................................................................h...h............hsht...h......h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	15	235	306
+10369	PF10537	WAC_Acf1_DNA_bd		ATP-utilising chromatin assembly and remodelling N-terminal	Finn R, Coggill P	anon	PROSITE_PS51136	Domain	ACF (for ATP-utilising chromatin assembly and remodelling factor) is a chromatin-remodelling complex that catalyses the ATP-dependent assembly of periodic nucleosome arrays. The WAC (WSTF/Acf1/cbp146) domain is an approximately 110-residue module present at the N-termini of Acf1-related proteins in a variety of organisms. The DNA-binding region of Acf1 includes the WAC domain, which is necessary for the efficient binding of ACF complex to DNA.	25.00	25.00	27.20	25.50	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.27	0.72	-3.85	28	339	2009-01-15 18:05:59	2008-03-05 13:56:12	4	46	223	0	226	350	0	96.40	36	8.79	CHANGED	ccVahlptTpEhFpsY--Yh......pRhshYppchaoCc.............lTG+SsLTahEALcSE..................ccttcplcp.FPptL+pPlLchlp.aspho+l-pLV-claphhKscaFsGEpV	.............pVahh..TtEhFpsY-..-..ah......pR......h....h...hsp...........plWoCp.............lTG+..ssLTa.EALcSE........................p.cst.cplpp.FPp.LctPlLchlp.asph.o...pLccL.......s.........-p.l............ath....h+scaasGEpV.....................................	0	67	116	180
+10370	PF10538	ITAM_Cys-rich		Immunoreceptor tyrosine-based activation motif	Finn R, Coggill P	anon	PROSITE_	Domain	Signal transduction by T and B cell antigen receptors and certain receptors for Ig Fc regions involves a conserved sequence motif, termed an immunoreceptor tyrosine-based activation motif (ITAM). It is also found in the cytoplasmic domain of apoptosis receptor.	25.00	25.00	28.30	27.30	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.83	0.72	-6.84	0.72	-4.39	6	300	2009-01-15 18:05:59	2008-03-05 14:30:42	4	5	137	0	0	316	0	24.00	71	2.81	CHANGED	+pGCYRTLulFRY+SRCYVGLVWC	....sGCYRTLsLFRYKSRCYIhThWs.	0	0	0	0
+10371	PF10539	Dev_Cell_Death		Development and cell death domain	Finn R, Coggill P	anon	PROSITE_PS51222	Domain	The DCD domain is found in plant proteins involved in development and cell death. The DCD domain is an approximately 130 amino acid long stretch that contains several mostly invariable motifs. These include a FGLP and a LFL motif at the N-terminus and a PAQV and a PLxE motif towards the C-terminus of the domain. The DCD domain is present in proteins with different architectures. Some of these proteins contain additional recognisable motifs, like the KELCH repeats or the ParB domain.	27.80	27.80	27.80	31.50	27.40	27.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.70	0.71	-4.59	10	245	2009-01-15 18:05:59	2008-03-05 14:41:54	4	20	39	0	127	228	2	119.10	44	24.57	CHANGED	LGGsIFsCNssThcECac+pLFGLPu+ahsaV+sIKPGLsLFLFNYss+pLHGIFEAoSpGthNI-spAatspt..s........opaPAQ....VRh+lthpChPLsEspF+ssIhpNYhs.......ss..KFRaELo+sQspcLlcLF	........................uGhIFhCNspThpEshc+pLFGLPtp.htc...V.c.sIcPGhsLFLYsass+pLaGlFEAsS.GGhNI.-PsAapspt.............ppFPAQ....V+hph.ct..Ch..PL...EspF+ssl.....pahs.......t...KFphELshtpshpLhpLF..............................	0	20	76	103
+10372	PF10540	Membr_traf_MHD		Munc13 (mammalian uncoordinated) homology domain	Finn R, Coggill P	anon	PROSITE_PS51259	Domain	Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical.	29.10	29.10	29.10	29.10	28.50	28.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.37	16	574	2009-01-15 18:05:59	2008-03-05 15:06:33	4	32	217	2	337	493	0	126.90	35	9.55	CHANGED	-sslpPLMDaLDspLulhscsh.KpshpRlLp.tLWchVlsplcctl..s..pp........................................................htpp+sLosppsshlphsLpslcpaFHA......pGpGLp.........................hshLp+oschpsLcptLpLaspsT-pLIcpF	......................................................-ssltPLh-a.....LDs.sLslhspshpcss..h.p+VLp.cLW+h..Vlssh-chl...lPshsct..........................................................................................................ppt+sLoscpsshlchsLcsl.p.paFHA......tG..s..G.L..........................hshL.KSschp...........sLchtLpLYspsT-pLIcpa....................................................	0	83	129	238
+10373	PF10541	KASH		Nuclear envelope localisation domain	Finn R, Coggill P	anon	PROSITE_PS51049	Domain	The KASH (for Klarsicht/ANC-1/Syne-1 homology) or KLS domain is a highly hydrophobic nuclear envelope localisation domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes [1]. During meiotic prophase, telomeres cluster to form a bouquet arrangement of chromosomes. SUN and KASH domain proteins form complexes that span both membranes of the nuclear envelope. The KASH domain links the dynein motor complex of the microtubules, through the outer nuclear membrane to the Sad1 domain in the inner nuclear membrane which then interacts with the bouquet proteins Bqt1 and Bqt2 that are complexed with Bqt4, Rap1 and Taz1 and attached to the telomere [2].  SUN domain-containing proteins are essential for recruiting KASH domain proteins at the outer nuclear membrane, and KASH domains provide a generic NE tethering device for functionally distinct proteins whose cytoplasmic domains mediate nuclear positioning, maintain physical connections with other cellular organelles, and possibly even influence chromosome dynamics [3].	23.00	23.00	23.60	26.70	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.03	0.72	-4.12	20	319	2009-12-22 14:12:53	2008-03-05 15:18:45	4	33	80	2	156	310	0	56.40	58	1.68	CHANGED	altRlhRsALPlQ.LLLLLLlslAsLlP.......hpt--aoCshsNNFARSFpPMLRYs......NGPPP.........h	...........alhRVlRA.ALPLQ.LLLLLLlsL.ACLlP........sEEDYSCshuNNFARSFaPMLRYs......NGPPPh...	0	26	37	87
+10374	PF10542	Vitelline_membr		Vitelline membrane cysteine-rich region	Finn R, Coggill P	anon	PROSITE_PS51137	Domain	In Drosophila melanogaster the vitelline membrane (VM) is the first layer of the eggshell produced by the follicular epithelium. It is composed of at least four different proteins. VM proteins are similarly organised with a central highly conserved 38-amino acid domain which is flanked by unrelated regions. The domain contains three highly conserved cysteines.	20.30	20.30	20.80	26.10	17.00	16.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.06	0.72	-4.33	2	82	2009-01-15 18:05:59	2008-03-05 16:08:28	4	1	15	0	37	86	0	36.90	75	25.87	CHANGED	uh.APPCPpNYLFSCQPNLAPsPCut.APuYGSAGAYo	.....SIPAPPCPKNYLFSCQPsLsPVPCS...A.P..A..s.SYGS.AGAYS.....	0	5	5	21
+10375	PF10543	ORF6N		ORF6N domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.73	0.72	-3.95	60	807	2009-01-15 18:05:59	2008-03-05 16:34:40	4	9	514	0	115	705	44	86.90	32	37.57	CHANGED	p.plhclRGp+VhhsppLAclYss-ocplppshpRNt.......cRFs.scahFpLstcEhcp...l+sphs..............................thstpstt.hhaTEpGsshLupl	...............t..phhphps.pVhhsppLAclYGs-.spplppshpcNt.......pRFs.scahFpL.....ss..pEhcp....l.+.s.p..hsh.p...................................thut.pttt.hlaTEpGhuhhuph...............................	0	42	87	110
+10376	PF10544	T5orf172		T5orf172 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.69	0.72	-3.61	204	1694	2012-10-01 19:55:08	2008-03-05 16:40:48	4	26	830	0	930	1844	598	92.50	31	29.87	CHANGED	GhlYl.h...........tp.t..st.......hKIGhTps...lpcRlpphp..............sshshphph......hth.............h...sstcl.EphlHpphps...hcl...............cpEaFc.....ls.....hcplcp.....hlc..pht	.................................................................GhlYl.l...................ppspshsp............ph..aKIGhT........hs....lppRhcphs....................................................................sclcV.......................................................hhss.Dhpsh....EspLh.cp..Fcc....t..h..h..p.......................................t+EhFc.........Vs..........plpphh....ph........................................................................	0	747	823	896
+10377	PF10545	MADF_DNA_bdg		Alcohol dehydrogenase transcription factor Myb/SANT-like	Finn R, Coggill P	anon	PROSITE_PS51029	Domain	The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.10	0.72	-3.79	116	1496	2012-10-04 14:01:12	2008-03-05 16:45:37	4	95	82	0	954	1699	0	82.30	20	23.59	CHANGED	LIphl+ppPsLacppp..pYp......sps................t.+ppsWppluppl...s..hs....s..p.....s+p....+WpsLR...spap+ch.cphp...............tspthtspah....ahcphpFL	.............................................LIphhcppPsLas...tpp...p.ap......spp..........................t.+p...psW..p...p...lu...ppl.......s.......hs............s..pp................hpp.+aps..LR.......sp.Yp+ch.+chp..................tttthhsph.....ahcphpFL.....................................................................	0	247	332	748
+10378	PF10546	P63C		P63C domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	25.00	25.00	36.80	36.10	24.70	15.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.12	0.72	-4.05	12	137	2009-01-15 18:05:59	2008-03-05 17:02:07	4	6	134	0	16	88	3	89.00	38	30.96	CHANGED	Ih-tFlucclpPahKpFPssaYcplFRLpGhpasscssp.RPthhGphTNcllYpRLAP...tlLEEL+cpssp.ttctt+.t+hHQhLTp-IGHPcL	............IhthFlhp-s.psWpKcF..sDshYctLaRhpGls..tcpss.+PhlauhloschIYs.lhP...plhs-lKtptsh.........tpKhHQaLssD.G........	0	5	8	11
+10379	PF10547	P22_AR_N		P22_AR N-terminal domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	25.00	25.00	27.80	27.70	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.66	0.71	-4.28	13	394	2009-01-15 18:05:59	2008-03-05 17:05:07	4	6	279	0	35	249	7	115.70	53	47.21	CHANGED	lssp..sVsFpGppL.l..sVppsG..psYsuMKPIVEuhGLuWpSQapKLhpscstsshlcIsh.VuuDGKpRcMlClPL+KLsGWLhoIsPsKVRPElRDKlIpYQcEChcVLa-YWp.pGtA.....R	............hshhsVPFHGss..L.a..lVs.aN..G..EPY.VPMKPlVpGMGL...s...Wp...S...Q...hsKL.+pRFts.sls.E....Is.........h..VA..........p.D......GKpRpMlsLPLRKLsGWLpTI....NP....N...K.V....+.PE.........IR-KVIpYQEECDDVLY-YWT.KGhVhNsR................	0	8	21	32
+10380	PF10548	P22_AR_C		P22AR C-terminal domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1]. It is found associated with Pfam:PF10547.	21.00	21.00	21.10	21.30	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.28	0.72	-4.11	16	459	2009-01-15 18:05:59	2008-03-05 17:07:46	4	11	251	0	11	261	0	73.00	45	29.70	CHANGED	pcp...ashpFT-pELppLsWLahuhp+spshhpplh.sLctlsSshusplYuhuhEYtpshcps+plLp+hstchc	..............pc+hssphoAcEhsoLVWLWpausRuQsLh+cLYPALKpIpSsYoG+sYDhuaEasYllshAR-VLlpcTcclD......................	0	2	6	9
+10381	PF10549	ORF11CD3		ORF11CD3 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	25.00	25.00	26.70	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.72	0.72	-4.24	9	414	2009-09-11 15:21:10	2008-03-05 17:11:40	4	6	250	\N	11	158	0	56.50	43	32.33	CHANGED	phohppphNphstEacpcKslAShsG+sLscW.+hcKPhL.AclcphcpchQlplshh	.......ShppEhNtsCt-hc+-KslAShsuptLNcW.+hsKPsllu+IcpLtppuQlhlshh..............	0	3	5	8
+10382	PF10550	Toxin_36		Conantokin-G mollusc-toxin	Finn R, Coggill P	anon	PROSITE_PS60025	Domain	The conantokins are a family of neuroactive peptides found in the venoms of fish-hunting cone snails. They possess a high content of gamma-carboxyglutamic acid (Gla) (4-5 residues), a non-standard amino-acid made by the post-translational modification of glutamate (Glu) residue. Conantokins are the only natural biochemically characterised peptides known to be N-methyl-D-aspartate (NMDA) receptor antagonists.	25.00	25.00	26.70	26.00	19.40	18.50	hmmbuild  -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.13	0.74	-6.50	0.74	-2.29	3	3	2009-09-10 23:18:32	2008-03-05 17:15:11	4	1	3	1	0	3	0	14.70	76	19.21	CHANGED	GEEElQKMspELhRE	GEEEVAKMAAELARE	0	0	0	0
+10383	PF10551	MULE		MULE transposase domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Babu and colleagues [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.32	0.72	-3.82	126	2654	2012-10-03 01:22:09	2008-03-05 17:40:22	4	142	229	0	1688	6089	517	90.00	18	13.95	CHANGED	us.....ah....h...........hhs.......hhGhst......phh....l........uhslh.ss.............Estcs.ap...hhhp.....shp..psh................hlloDtppulhpAlpp..la............Pt..sp..pphChhHlh...csht	................................................................................................hhuhstpt.....phh....sh........u.hs.l.l..ps.......................................Estcs..at...........ahhp..................................................phh....phhst...........p...sh..sllsD.p.pt...u....hhpAlpp..sa............Pp.....sp....pthCh.hHlhpsh.h...............................................	0	642	1072	1371
+10384	PF10552	ORF6C		ORF6C domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	21.90	21.90	21.90	21.90	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.26	0.71	-4.36	23	471	2009-01-15 18:05:59	2008-03-06 12:49:20	4	10	383	0	34	350	3	108.30	23	46.84	CHANGED	ptltlhhps.cphccclpplcpclpcLc....pshsLhss-scplp+pVpppVsphLGG+tosAYpc..l+pKlapDIapplK+pFsVsoYssI++Kch-pAhchl.ssapssp..shptcIp	.................................................h.hhhps..phppphpp.lcpc.......lptLc..................pp.sl...stsptp....plpptlpp+Vh....thhs.Gh.t..s.............sap.........c....hppp...lapp........h.hppl....KctFsV.spYspl.+pca-cAlpal...ppWpPsh..tht.pI.................	0	7	24	29
+10385	PF10553	MSV199		MSV199 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This domain was identified by Iyer and colleagues [1].	21.10	21.10	21.50	22.80	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.79	0.71	-4.29	16	37	2009-01-15 18:05:59	2008-03-06 12:58:01	4	10	5	0	0	37	36	134.10	32	36.17	CHANGED	hlDIhp...FIctssa-hchh..hhpphWhshhs.......cpplhIosslLpaltYpsp...........app.+cs..FcchLcpNpIpa............................................pclpas-s.lpp..YsplpcEhcpls..sslspp+WlIlpscsFKhhIh+LNTpsuchIRcYYlplEcllp	...................hlDIhpFlchspaclshs..hFs.hW.slss.................ppphhlspslLcWhGYpGc...............hppQ+ps..Fp+hLcpNpIpY............................................pElshp-..lp...YsplpcElptls.ssslspp+alIhcscshKhuIMpLpTKsuchIRcYYlsLEcllp..........................	0	0	0	0
+10386	PF10554	Phage_ASH		Ash protein family	Iyer LM, Bateman A	anon	Iyer LM	Family	This family was identified by Iyer and colleagues [1]. It includes the Ash protein from bacteriophage P4.	21.80	21.80	21.80	21.80	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.35	0.72	-3.71	19	596	2009-01-15 18:05:59	2008-03-06 14:21:45	4	7	351	0	35	460	0	95.40	36	41.17	CHANGED	YospAstKouAGhssPphstApscA....usFh..ssths............................thplM..........VupAGtPpuhPsSh....................loGhusPVphsT.clsss.G..GshhphshEAA..................hMsTl............ohspsph	.................................Ysh.AshKsuAG.hts.p.......st.cA......ssFh..shthp.......................................hhp.M..........VupAGt..spshPsSh....................hsGhusP.Vphs.T.p.clssS.G..Gs..hphhhEAA..................hMA.Th.......s.spsp....................................................................................	0	1	8	20
+10387	PF10555	MraY_sig1		Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 	Finn R, Coggill P	anon	PROSITE_PS01347 	Domain	Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (mraY) is a bacterial enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl-phosphate. It is an integral membrane protein with probably ten transmembrane domains. This domain is located at the end of the first cytoplasmic loop and the beginning of the second transmembrane domain.	20.10	11.30	20.10	18.00	20.00	11.10	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.95	0.74	-5.85	0.74	-4.24	64	3122	2009-01-15 18:05:59	2008-03-06 15:12:43	4	4	3072	0	644	1899	1136	13.00	74	3.72	CHANGED	KpuTPTMGGllll	..KpGTPTMGGllIL.	0	203	418	541
+10389	PF10557	Cullin_Nedd8		Cullin protein neddylation domain	Finn R, Coggill P	anon	PROSITE_PS01256	Domain	This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue [1].	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.12	0.72	-4.15	109	1474	2009-01-15 18:05:59	2008-03-11 09:11:25	4	25	308	28	994	1441	15	66.30	42	8.55	CHANGED	lpp-RphhlpAuIVRIMKsRKplsHspLlsElhpplpp...+Ftssss.IK+pIEpLI-+EYlcRs..psts	.....................tpDRphtlpA.A....IVRIMKsRKp.lsHspLlsEl..............hpQLpt...........+Fh..Pp...sshI.K.........KpIEsLI-+-YlcRscss..t..................	0	369	551	808
+10390	PF10558	MTP18		Mitochondrial 18 KDa protein (MTP18)  	Tolvanen M, Bateman A	anon	Tolvanen M	Family	This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis [1]. Overexpression studies suggest that MTP18 is required for mitochondrial fission [2].	25.00	25.00	61.10	35.40	22.60	22.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.83	0.71	-4.34	24	236	2009-09-11 16:45:10	2008-03-11 10:46:53	4	3	206	0	171	223	16	155.30	37	70.83	CHANGED	oslRYAu.h.Rhtp.........uYssDlGEuFRPls.shLV+uuYGVSauYlluDls...cuhKshhcscthhs..............................................................................hpchph.ssscpslaQulAShulPuFTIHolVpaSuhhhpps..+........shh.RpWsPsulGLuslPhLsa.hDcs......V-psl	.....................................................h...RYluYss-lGEuFRsls.shlV.......puuYGVuhuYlluDss..pcGhKAhhpspt.hs....................................................................................pchth...ssscphlaQulAShulPuFTIp.plsthSthhhpss......+.............shh..RpWsP..sulGLuslPhl.a.hDcsV-th........................................	0	59	93	140
+10391	PF10559	Plug_translocon	Plug_Sec61p; 	Plug domain of Sec61p	Coggill P	anon	Finn R	Domain	The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [1].	22.10	22.10	22.70	22.20	21.80	21.30	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.42	0.72	-4.44	68	686	2009-01-15 18:05:59	2008-03-13 11:30:10	4	8	470	12	424	593	89	34.60	52	7.47	CHANGED	llYhlhoplPLYGl.....sssssDsFhhhRslh.AuspG	........hIFLVhs.QlPLaGI........hSocouDPFYWhRsIL.ASNRG..	0	141	242	351
+10393	PF10561	UPF0565		Uncharacterised protein family UPF0565	Coggill P	anon	UPF0565	Family	This family of proteins has no known function.	25.00	25.00	25.10	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.93	0.70	-5.53	12	182	2009-01-15 18:05:59	2008-04-16 15:38:41	4	5	101	0	127	176	0	192.10	24	72.60	CHANGED	shpl.slsGhp..pRsNsllhhtPhhp...............spp.ssptllaFsGDhpsa.pp......hppsssssp.hpasLEslAhlLsp+Fsts......HIhVl+sSph..spFSsasNFlpussh............................................GsPcp...o.sthtuhpHLhpLL.shhpclhp...t.ph..p.h......................................................................................................................................................................................s.shtchpLhLlGFSKGCsVLNQllhEhp.......................ht..ssphphhlspIsshYaLDsGaststtsalTppssLcpLupt......ulplalHsTPaQlpDshRsWI++EhcpFlchLcphuhsh	...............................................................................................................................sht..h.hl..th..t.......hhhlcs..h.....t....husapshl.ss..............................................G.s..............u...th...lh.t.........................................................................................................................................................................................................................................................h.lhGFSKGssVlsphhhEht.................................................................th....h.ht.lpthaalDsGhs.t.tsa.s..thlpthsp.........th.hhhHhTPhphts...Rshlt.E.t.h.phLt......s...............................	0	47	64	100
+10394	PF10562	CaM_bdg_C0		Calmodulin-binding domain C0 of NMDA receptor NR1 subunit	Coggill P	anon	Pfam-B_7118 (release 22.0)	Domain	This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a critical role in learning, memory, neural development, and synaptic plasticity. Calmodulin (CaM) regulates NMDARs by binding tightly to the C0 and C1 regions of their NR1 subunit. The conserved tryptophan is considered to be the anchor residue [1].	20.20	20.20	20.20	23.20	18.10	19.00	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.85	0.72	-7.01	0.72	-4.09	4	144	2009-01-15 18:05:59	2008-04-16 17:43:46	4	12	71	0	48	149	0	28.80	70	3.30	CHANGED	IsYK+H+shKcKphELA+pAsD+WRuNIp	.IAYKRHKDARRKQMQLAFAAVNVWRKNLQ...	0	11	15	32
+10395	PF10563	CdCA1		Cadmium carbonic anhydrase repeat	Bateman A, Coggill P	anon	Bateman A	Repeat	This domain is the cadmium carbonic anhydrase repeat unit of the beta-carbonic anhydrase of a marine diatom [1], that uses both zinc and cadmium for catalysis of the reversible hydration of carbon dioxide for use in inorganic carbon acquisition for photosynthesis (thus being a cambialistic enzyme). Compared with alpha- and gamma-carbonic anhydrases that use three histidines to coordinate the zinc-atom, this beta-carbonic anhydrase has two cysteines and one histidine, and rapidly binds cadmium [2].	20.80	20.80	21.80	30.80	19.70	20.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.41	0.70	-4.83	18	25	2009-01-15 18:05:59	2008-04-16 17:46:55	4	3	10	6	16	27	2	195.00	32	65.05	CHANGED	hWpuulsssssahplhs.+hshs-hD.....cssDG.s.ss..sphstP......................................+hLushh.hsspcGhRsp+h.cstsp.ss.................psGcs.pVHhsHSu...hhuCG....Ypp.ahsGhFsshs..................hssasu..GutsltsAsGV...l.slVs..-EpYhY.shlcGhhl-sctp.....................cpp.lssuauslpaplDtpsahIoAuu	.............apuuhssVNlHaHlGsEHhShG-aD.....css-G.s.ss..sphsts......................................+hhs..uhtshs...hscGh+shchstssst.ss........YtapaC.thpVGcTYEVHWsHSu...hGACG....Ypp.ahsGVFsshs..................hsshsu.tus...tsltsulGVpuQVaslVNt.-E..p.hhY.shlcGhhl-ssts.......t-hshY.GSTTGpt.csN.-lCsua.usloWplDRpCHhloAuu.	0	11	15	16
+10396	PF10564	MAR_sialic_bdg		Sialic-acid binding micronemal adhesive repeat	Coggill P	anon	Chen Z	Repeat	This domain is a novel carbohydrate-binding domain found on micronemal proteins. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Toxoplasma gondii can infect and replicate within all nucleated cells [1]. This domain interacts with sialylated oligosaccharides; the protein in Toxoplasma gondii is a monomer but several MAR domains are carried on the protein. Each MAR domain contains one central sialic acid-binding pocket [2].	25.00	25.00	26.00	25.20	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-10.82	0.72	-4.23	17	151	2009-01-15 18:05:59	2008-04-16 17:48:43	4	12	14	13	55	153	0	94.00	27	32.00	CHANGED	LDpaC.sphuppsspsshp.hh........hhhAR.t.ttptttsh.WRCYspsphphstst.....ClDsCGshhs..C.uslpt.ssphhs+s....th.plIsppt......................hC	.........................lDthC.tph.tthstphhp.shsss......shVARhsh.s.psup..pst..WRCYstppLshstps.t...ClDsCGshhs..C.Gs.....lstsssp....ahTtp....pl.phIppt........................................	0	34	36	54
+10397	PF10565	NMDAR2_C		N-methyl D-aspartate receptor 2B3 C-terminus	Coggill P	anon	Pfam-B_53396 (release 22.0)	Domain	This domain is found at the C-terminus of many NMDA-receptor proteins, many of which also carry the Ligated ion-channel family Pfam:PF00060 further upstream as well as the ANF_receptor family Pfam:PF01094. This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region also carries a number of potential N-glycosylation sites [1].	25.00	25.00	32.80	31.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	681	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.28	0.70	-5.85	11	229	2009-01-15 18:05:59	2008-04-16 17:49:41	4	14	86	4	78	194	0	403.00	39	42.23	CHANGED	HLFYWpLRaCFhGVCSG+PGLlFSISRGIYSCIHGVpIE-K...thsSPoh....shssopSNhL+LLRoAKsMssloslNG....SP+sAh-Fh+p..cSulhDhupc+tshstsc.....s.sa.sc-shFuD.hS-lcpphuNlphccsNsYtcp.hpHthshst...........pPpSlGuuuSh-Gshs..................sopPRulh....KKslDhlttpsssssss.ptthssh.G+.sashKS.........sRYh.......st-..sh+SDlSDhSo+ssoYts.Eus..t+++pph+DoLKKRsuouK..R-hsElEL.......................shh+s.......spuus..cphYhh.pDKEslpsFalDQh+s+EGss..h-clDhs-hauscussh+pssss.........hthsoShlphc-h.....p....tpthspthshuspsps......sstussthuss..aCRSChS..............................phsuauuhs..tpsspusshRC-uCp.+sGNLYDISEDp.Lpct.........................tpsttupsshstthsQssstphp+pptttpLpRQHSYDsh.l-ht+Ets........................h.ssRSVSLK-K-Rah-Gsshh....................................h......utchhss+ssthhuucsttt.p.................sst..............hphSKSLYPD+sopNPFlsTasD.......D...QpLlHGupua.hhKpphs.............httpsps.tposhussSassssu..........Rhsp-lslu.....ppshshsssp...h.......ssPRshNuu..oNs+VYcKlsSIESDV	...................HLhYWphRash...po.sp.sh..lh..uhSRGIYSChpGVt...tp.....tsPsh....shs.spuNhL+hLpsAKshssh..sshps....S.ppshchh..................................................................................................................................................................................................................DhS-hSs+sssahp.-s......+p.p.+ssh.KRs.su+..+-.s.................................................tt.p..pp.a...t-pt...sh.....p..Es.sh..Epl-hs-.ap-ts-sh......++ssss.........h..sps..p.ccs.............hhtpthshtthsts.......s-hppp.tts..aCRSC.S..............................ph.sYus............p.shpssh+C-uCh.+hGNLYDIsEDp.Lp-h................................tts.t..tthsps.s.phtp.tp...p.lpRQHS..............................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	13	31
+10398	PF10566	Glyco_hydro_97		Glycoside hydrolase 97  	Coggill P	anon	Naumoff D	Domain	This domain is the catalytic region of the bacterial glycosyl-hydrolase family 97. This central part of the GH97 family protein sequences represents a typical and complete (beta/alpha)8-barrel or catalytic TIM-barrel type domain. The N- and C-terminal parts of the sequences, mainly consisting of beta-strands, form two additional non-catalytic domains [1].  In all known glycosidases with the (beta-alpha)8-barrel fold, the amino acid residues at the active site are located on the C-termini of the beta-strands [2,3].	28.00	28.00	28.10	28.10	27.90	27.80	hmmbuild  --amino -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.74	0.70	-5.30	173	795	2012-10-03 05:44:19	2008-04-16 17:52:05	4	17	278	12	178	849	187	272.00	35	40.12	CHANGED	D.s.SWIK.PGKhsas.WWshtss............................tu...s...sscshKpYIDFAAchGhcalLl.........DtGWt.................sh..ps.sc....h-lpcLspYA+pKGltlhLWhppps...............hcpp.h.-cthphhpchGlpGlKsDFhsp...................-sQhhlpaYpcllcpAAca+lhVshHG.sh+PsGhpRTYPNhlspEuV+GtE..pths.......sst.spHsshLPFTRhluGPMDYTPGhhp.tht..................pspspsT...hu+QLAhaVlh.SPlQMh..uDtPpsY.....pp.......shpFlcslP	..................................DsSWIKPG.Khshs.WWphhss.......................t.s.ptuh...sspshKcYIDFA.Ap.....pGh-hlLl....stGWp....................t..hshhp.shs-...........hDlppLscYA+pKG..lhLhhpac..s..................................h-pp...h.-cthphhpchGlpulKss..ahss..........................ssQhhssaYhcllccAAca+lhVshHt.sh+P.oGlpRTYPNhlspEus+GtEh....ptas........sspspHsshLPFTRhluGPMDYTPGhhppthp................spsts.poT.hu+QLAhaVlh.SPlQMh..ADhPpsYtct.........sshpFlcsVP....................................................................................	0	71	152	170
+10399	PF10567	Nab6_mRNP_bdg		RNA-recognition motif	Griffiths-Jones S, Coggill P	anon	Pfam-B_57293 (release 21.0)	Domain	This conserved domain is found in fungal proteins and appears to be involved in RNA-processing. It binds to poly-adenylated RNA, interacts genetically with mRNA 3'-end processing factors, copurifies with the nuclear cap-binding protein Cbp20p, and is found in complexes containing other translation factors, such as EIF4G as in Swiss:P39935 and Swiss:P39936.	25.00	25.00	31.10	31.10	24.60	19.60	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.09	0.70	-5.44	5	25	2009-01-15 18:05:59	2008-04-16 17:54:03	4	4	24	0	15	24	0	317.80	46	30.36	CHANGED	INYKVLPKGcDsY+TRSLLFENV-..+-lDLHsFl+pFVKauPlESlYLIcsss...............csscsh-sDscN.............................pSILLSFLTKssCLDFYNNlLQRLSEFKTpL+SscLolSFVslpY.spp............sDEEush...p.hl..suLchNIlo+GATRSIsVEFpssVp..cpDhlpcKLPFLcsScNKRYILEuVDlINA--ssssFPpNYsILTFLNISMAlEVhDaL+t...p+shuIS+ChFVolss.h..................p+.Ss.Ssssssssp.psscosSVSshSt...................lSLossooslS..LscElDs....ht.lcL-tpsLplshS-Y.pPhIEpHscHL	........IsYKlLPp....GDDsYRTRSLLhENV-..cSIDLHShlcsFVK.sslESsYLIcus................psscsp-s-scs.............................hSILlSFLTKusCLsFYNNlLQR...LSEFKThLKS-uLsLpFVsLsYcscshsp..tt.......................t.p.NsEEsDl....s.hl.suSL+aNIsN+sATRSIhIEFc.osVc......KsD.LhcKKL.pFL.cpucNKRYILESIDLVNs-ss.sspFPcNYAlLTFLNISMAlEVLDYLKph..o+sLGISKChaVSlsshs.p..............ss++hSs.SsssusNscossssssspSshSs...........................S.hSLoSh.uSsVS..Ls-ElDhhs.pKLpulcLcsphLplshp-YpsPpIEpHosHL........	0	1	6	13
+10400	PF10568	Tom37		Outer mitochondrial membrane transport complex protein	Wood V, Coggill P	anon	Pfam-B_30563 (release 22.0)	Family	The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane [1]. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex [2].	21.50	21.50	21.50	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.44	0.72	-3.71	17	336	2012-10-03 14:45:55	2008-04-16 18:03:22	4	12	211	0	210	319	1	67.70	30	20.00	CHANGED	LHlWGhshslssIsspClAshahhphshspp..........hplVtSsNsslSsoscLPsLhs..ssphls....GatsIlpaLp	..........lahWus..s..au.LPSlcspsLAlhsYh+hssss...........hclhtpsN.s.h.hSPoGcLPhLps.....ss....ph..lo......thtpIlpaL.........................	0	40	81	150
+10401	PF10569	Thiol-ester_cl		Alpha-macro-globulin thiol-ester bond-forming region	Finn R, Coggill P	anon	PROSITE_PS00477	Domain	This short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.	20.10	20.10	20.10	20.10	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.30	0.72	-4.72	83	1638	2009-09-13 17:40:59	2008-04-17 09:17:48	4	94	646	55	611	1531	44	29.30	44	2.09	CHANGED	sLspLlphPtGCGEQsMlphsPslhshpY.Lc	........tlppLlphPaGCGEQsMsthsPslhshpYLp.........	0	121	201	399
+10402	PF10570	Myelin-PO_C	Myelin-PO_N;	Myelin-PO cytoplasmic C-term p65 binding region	Finn R, Coggill P	anon	Pfam-B_1437 (release 22.0), PROSITE_PS00568	Domain	Myelin protein zero is the major myelin protein in the peripheral central nervous system and is essential for normal myelination. The family is a single-pass transmembrane molecule containing one Ig-like loop in the extracellular domain and this highly basic 69 residue C-terminal cytoplasmic domain which is the region that interacts with protein p65 [2].	25.00	25.00	29.80	29.30	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.35	0.72	-3.91	4	47	2009-01-15 18:05:59	2008-04-17 09:23:04	4	3	30	0	19	35	0	66.80	75	27.58	CHANGED	VRaCWLRRQuhLQRRLSAhE+GKLp+.AKDuSKR.uRQsPVLYAMLDpSRSsKuASEKKuKGh.GESRKDKK	............lRYCWLRRQAALQRRLSAMEKGKLHKsuKDuSKR.GRQTPVLYAMLDHSRSTKAASEKKuKGL.GESRKDKK.....................	0	1	2	4
+10403	PF10571	UPF0547		Uncharacterised protein family UPF0547	Coggill PC	anon	UPF0547	Domain	This domain contains a zinc-ribbon motif.	27.30	27.30	27.30	27.40	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.04	0.72	-7.45	0.72	-4.24	31	219	2012-10-03 10:42:43	2008-04-17 09:30:18	4	12	202	0	65	235	57	25.80	44	10.55	CHANGED	KpCPpCsppl........shusphC....shCGasFpt	...+pCPcCpppl........stuscpC....PpCGatFh.p...	0	21	30	44
+10404	PF10572	UPF0556		Uncharacterised protein family UPF0556	Coggill PC	anon	UPF0556	Family	This family of proteins has no known function.	25.00	25.00	31.70	30.30	21.10	16.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.09	0.71	-5.04	6	52	2009-01-15 18:05:59	2008-04-17 09:36:22	4	5	40	0	36	49	0	142.50	48	69.88	CHANGED	MAs.............hs.lh.hhhhh.sspuhpcspohEFDlRPGG.laoFopslt...cYpCsFTYAuQGGTNEpW.MSlGLS-DsphFSCSlWRPQGKSYLFFTQFKAEl+GAKIEYupAYSQsussupuDVPLKsEEapVo-osVopRsGpF+upLuKLsllu+spHDEL	................h...............hh.hhhhh........tusp.p........spohtFDl+PGG..lcoFopslt......capChFTYAuQ..GGT.NEpWpMolGhS-DpphFoCo..lWR...P...Q.G.KSYLaFTQFKAEl+G.AcIEYuhAYSpsuhttpuDVsLKsEEFpVoc..o..sVspRsGtF+ucLSKLslVA+t..t+sEL.........................	0	13	16	22
+10405	PF10573	UPF0561		Uncharacterised protein family UPF0561	Coggill PC	anon	UPF0561	Family	This family of proteins has no known function.	25.00	25.00	25.40	25.90	22.80	24.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.65	0.71	-4.28	5	61	2009-09-10 19:05:18	2008-04-17 09:38:23	4	4	45	0	43	47	0	107.90	50	52.62	CHANGED	MEs.u-upGcuVphKPGGRLDMSHGFVHHIRRNQIARDDYDKEVKQ.AKEKQRRRHTssPRRPRRPDLQVYpPRpRpGSp.ssss-sEEpsESoSo.poEsEssGspLFpLDYEADuG-ITSlIVaK	...........................thp.KPGGRLDMsHGFVHHIRRNQlARDDYDKcVK......Q..AKEchR+R+T...suPpR....P..R+P..D.....l.QVYhPR+R..cs.o...tt.s..ss-hEE...ssESoSS.to-.EspuppLFpL-YpADuGclTSlIVap........................................................	0	10	13	23
+10406	PF10574	UPF0552		Uncharacterised protein family UPF0552	Coggill P	anon	UPF0552	Family	This family of proteins has no known function.	22.20	22.20	22.40	23.70	19.90	22.00	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.40	0.70	-4.89	5	71	2009-01-15 18:05:59	2008-04-17 09:41:11	4	4	46	0	43	55	0	196.30	55	88.99	CHANGED	MSRIYpsTALpNKsVHsE+asGoW-PusaQuG-GVLLEGpLlDaSRHoIoDsKs+.......KERYYVLYIRPSRIHRRKFDsKGNEIEPNFSDTKKVNTGFLMSSY............................KVEAKG-SDRLot-QLssLV...NKspLl.......KIT-+H.sP+ETaAFWhPEuEM-KTELEsGpEVRLKT+GDGPFlFSLAKlDSGTVTKCNFAGDupAGASWTDNIMApKSspssu.ScspuQGDGA-DDEW	..................MShIYpsssLpscsVps.phsusWsPs..t..aQuGsGVLLEGpLh.DlSRHsI.Dspsp.......KpRaaVLYlcPuplH+R+FDs+GpEIEPNFSsT+KVNTGaLMSSY............................KVEAKG-oDRLo.-tLpsLV....sKs-.LL.......ulTpph..oPspolAFWhPEuEM-thELElGstVRLKT+GDGPFl-SLAKL-uGTVT.K.CNFA.....G...DsKTGASWTDNIMApKsocsss..sE...h.+p.QGDGA-D-EW.......	0	18	21	26
+10408	PF10576	EndIII_4Fe-2S		Iron-sulfur binding domain of endonuclease III	Finn R, Coggill P	anon	PROSITE_PS00764	Domain	Escherichia coli endonuclease III (EC 4.2.99.18) [1] is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidised pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand [2]. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease [4].	20.50	19.60	20.50	19.60	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.58	0.73	-6.71	0.73	-3.58	505	3890	2009-01-15 18:05:59	2008-04-17 09:52:34	4	11	2745	20	789	2381	391	17.00	50	6.34	CHANGED	Cps+.pPpC....stCPlp..sh.C	CpAR.KP+C....shCslp..ch.C.....	0	236	509	651
+10409	PF10577	UPF0560		Uncharacterised protein family UPF0560	Coggill P	anon	UPF0560	Family	This family of proteins has no known function.	19.40	19.40	19.40	19.50	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	807	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.66	0.70	-13.35	0.70	-6.28	7	258	2009-01-15 18:05:59	2008-04-17 09:54:33	4	17	49	0	134	241	0	425.80	28	87.35	CHANGED	lplKVQV.DsushpPLAsAsVElFuNpoul.ASGsTsuDGsshlthsY+LGo.llVoAoKpuYVsNSlPW+spRLPlauSVSLhLLPERsATLhlYEDlVpIluG..GARsQPhVpFQR+AlpLP.ssoYssLoAhLTsAuo..chcuFPahhGh-.uNuo.Gssshh-LsPlAAlSVHLhsusGspl.lsGPIpVSlPLPscss.LptsspVPAWRFD.phGsWl+sGhGhl+c-GsQLhWTaluPQLGYWlAAhsPspsG.lhsp....DIsoYHTlFLLuILGuhAlllLlLLClLLYYCRR+CLKPpppHRKLpLs.sL-..K+DQATShS+lNLl.....................................osts.ts..ss.L+...sopcDhspp..tphlpHpccspoth.....................tph-.a.hKuppsut.ppt.t.h.p--.ppuhsoh.sp....cp..tutusttphussss.sh.........t..tpths-u+ss-hhhopSlDpLpRPo..sh.opPGQlIhCuSlDplp-us.YRpshPTLVIPAHYh+LPuEtshsupshh.pspppp-htshpst.tpsa.........Q..stt.ptQthusppupsupuppW.u..ssshutSVoIPsshN-ushAQh.NuElQhLTEKpLhELGs...hPHPRAWFVSLDGRSNApVRHSYIDLQpuspstS......................sDASLDSGVDhNE.+suR+hc...............hpE+pt.pt.tssss....huhopLlYhEDh-.SuSEstsshs.SPEDsuLpslL-tuspsphsphsphtcpps+possSshps.sp.ppc.stpsptc.s-pst--tspsKKSPWQKREERPLhsFN	.............................................................................................................................................................................................................................................................s........h.......................h...h....s..h.hphsh.......................ss.h.ha.ap.t...............G..W.pts.s.l............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	18	26	57
+10410	PF10578	SVS_QK		Seminal vesicle protein repeat	Finn R, Coggill P	anon	PROSITE_PS00515	Repeat	\N	25.00	2.00	26.50	2.10	18.20	1.70	hmmbuild  -o /dev/null HMM SEED	12	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-5.92	0.74	-5.80	0.74	-3.09	13	217	2009-01-15 18:05:59	2008-04-17 10:01:42	4	4	4	0	105	234	0	12.20	53	57.33	CHANGED	uQlKSFGQhKSp	....uQ.Ko....FuQpKo..	0	92	92	92
+10411	PF10579	Rapsyn_N		Rapsyn N-terminal myristoylation and linker region	Finn R, Coggill P	anon	PROSITE_PS00405	Family	Neuromuscular junction formation relies upon the clustering of acetylcholine receptors and other proteins in the muscle membrane. Rapsyn is a peripheral membrane protein that is selectively concentrated at the neuromuscular junction and is essential for the formation of synaptic acetylcholine receptor aggregates. Acetylcholine receptors fail to aggregate beneath nerve terminals in mice where rapsyn has been knocked out. The N-terminal six amino acids of rapsyn are its myristoylation site, and myristoylation is necessary for the targeting of the protein to the membrane [1].	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.47	0.72	-4.18	4	91	2012-10-11 20:01:02	2008-04-17 10:43:49	4	29	73	0	53	118	3	78.90	50	17.87	CHANGED	MGQDQTKQQIEKGL+LYQuNpTpKALclWtpVLc+To-.sG+FRlLGCLITAHSEMGKY+-MLcFultQlssAREh-DP-	..........MGQcQs.KQpIE+.GLp.LY.puN..ppccALpsWp+sL...c...K...os.c.h...t.s.RF...p...lLGtL.hpAHsEhG+Y+-MLcFAlhQl-hAcELEDss.................	1	12	15	35
+10412	PF10580	Neuromodulin_N		Gap junction protein N-terminal region	Finn R, Coggill P	anon	PROSITE_PS00412	Domain	\N	18.50	18.50	22.20	22.20	15.90	15.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.51	0.72	-4.30	3	72	2009-01-15 18:05:59	2008-04-17 10:48:03	4	3	46	0	26	57	0	28.50	80	13.39	CHANGED	MLCCIRRTKPVEKNEEADQKIEQDG..IKPEDKA	.......LCChRRTK.pVEKN--.DQKIEQDG..IKPEDKA..	1	1	3	9
+10413	PF10581	Synapsin_N		Synapsin N-terminal	Finn R, Coggill P	anon	PROSITE_PS00415	Domain	This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin [3].	25.00	25.00	25.50	25.50	22.50	21.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.51	0.72	-4.13	5	136	2009-01-15 18:05:59	2008-04-17 11:41:42	4	5	42	0	56	160	0	31.30	77	6.20	CHANGED	MNYLRRRLSDSuFluNLPNGYMsDLQRP-PPu	.......MNaLRRRLSDSoFhANLPNGYMoDLQRP-ss.......	0	5	11	28
+10414	PF10582	Connexin_CCC		Gap junction channel protein cysteine-rich domain	Finn R, Coggill P	anon	Pfam-B_1437 (release 22.0), PROSITE_PS00408	Domain	\N	22.50	22.50	23.20	24.60	22.10	22.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.22	0.72	-4.16	76	1238	2009-01-15 18:05:59	2008-04-17 11:42:18	4	11	126	6	649	1009	0	66.10	49	21.43	CHANGED	hEluFlhsQYhLY.GFplsslahCs.ptPC...Pps.VDCFlSRPTEKTlFllFMhslos...lsllLNlhElhaL	..........................................hEluFlhsQYhLY..GF.p..lssla.pCs......p.............PC.............Pp.s..VDCFlSRPTEKTlFllFMhslus...lsllLNlhElhaL............	0	56	121	321
+10415	PF10583	Involucrin_N		Involucrin of squamous epithelia N-terminus	Finn R, Coggill P	anon	Pfam-B_7423 (release 22.0), PROSITE_PS00795	Domain	This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane [1].\	  Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis [2]. The downstream part of the protein is represented by the family Involucrin, Pfam:PF00904.	21.50	21.50	77.20	77.20	18.70	18.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.66	0.72	-3.67	9	42	2009-09-11 05:37:53	2008-04-17 11:45:25	4	19	29	0	11	37	0	68.00	69	15.11	CHANGED	MSQQHTLPVTLPPALSQE.LKsVSPPssTQQEQhKQPTPLPsPCQKV.SELPscVP.cHtEKHso.VKG	MSQQHTLPVTLsPALSQE.LKTVsPPssTQQEQhKQPTPLPsPCQKVssELPVEVPsKpEEKHhTsVKG..	0	1	1	1
+10416	PF10584	Proteasome_A_N		Proteasome subunit A N-terminal signature	Finn R, Coggill P	anon	PROSITE_PS00388	Domain	This domain is conserved in the A subunits of the proteasome complex proteins.	23.00	23.00	23.10	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.30	0.72	-6.55	0.72	-4.61	74	2896	2009-01-15 18:05:59	2008-04-17 11:46:05	4	19	554	763	1805	2718	83	22.80	63	9.05	CHANGED	YDpshosFSP-GRLaQVEYAhcA	.......YDpslTsFSP-GRLaQV.....EYAhcA...	0	629	1011	1482
+10417	PF10585	UBA_e1_thiolCys		Ubiquitin-activating enzyme active site 	Finn R, Coggill P	anon	PROSITE_PS00865	Domain	Ubiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin-conjugating enzymes (E2) [1]. This domain carries the last of five conserved cysteines that is part of the active site of the enzyme, responsible for ubiquitin thiolester complex formation, the active site being represented by the sequence motif PICTLKNFP [2].	19.90	19.90	19.90	20.20	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.45	0.72	-4.57	65	1276	2009-09-11 07:00:39	2008-04-17 11:47:32	4	44	343	39	841	1263	19	45.50	39	6.15	CHANGED	thTEsYssstcsspc..s...hPlCTl+shPpphpHCIpWA+.thFpphFs	............................hTpsYp..s..s.-..sspc...p......hPhCTl+shPpp..-HCI..pWA+..hFpphF............	0	310	475	688
+10419	PF10587	EF-1_beta_acid		Eukaryotic elongation factor 1 beta central acidic region	Finn R, Coggill P	anon	Pfam-B_9497 (release 22.0), PROSITE_PS00824	Domain	\N	25.70	25.70	25.80	25.90	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.64	0.72	-7.26	0.72	-3.79	37	495	2009-01-15 18:05:59	2008-04-17 12:56:35	4	11	254	0	245	487	0	27.50	62	9.97	CHANGED	LFGSD-E.EDcEAc+l+p.cRLAtYstKK	..LFG.S.D.-..E.-..ED.tEAt+l+E.ERLtpYspKK..	0	77	120	191
+10420	PF10588	NADH-G_4Fe-4S_3		NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	Finn R, Coggill P	anon	Pfam-B_202 (release 22.0), PROSITE_PS00642	Domain	\N	20.10	20.10	20.10	20.30	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.03	0.72	-4.72	191	4123	2009-01-15 18:05:59	2008-04-17 12:59:17	4	128	3222	15	1243	3421	1974	41.00	43	5.37	CHANGED	R+sllElLLssH....sh-CssC-.psGpCcLQchuhchGlpct+a	.......RcslhEhLLtNH....PL.DCslC-.puGcCcLQ.-huhthGhsppRa.........	1	463	862	1067
+10421	PF10589	NADH_4Fe-4S		NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	Finn R, Coggill P	anon	Pfam-B_339 (release 22.0), PROSITE_PS00645	Domain	\N	20.70	20.70	20.80	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.35	0.72	-4.81	299	3722	2009-01-15 18:05:59	2008-04-17 13:02:48	4	63	2661	15	1286	2965	2211	45.80	42	9.34	CHANGED	Vc.hspphhc.Fh...tcESCGpCTPCRtGot.hhhcllc+.l.tp...G..cu....p....................tpDl	............Vphspph.c..Fa.....t+ESCGpCTPCR-Gos.ahhcllc+.l..pp..Gcup.tDl...........................	0	477	891	1106
+10422	PF10590	PNPOx_C		Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region	Finn R, Coggill P	anon	Pfam-B_685 (release 22.0), PROSITE_PS01064	Domain	Pyridoxine 5'-phosphate oxidase (PNPOx) catalyses the terminal step in the biosynthesis of pyridoxal 5'-phosphate (PLP), a cofactor used by many enzymes involved in amino acid metabolism. The enzyme oxidises either the 4'-hydroxyl group of pyridoxine 5'-phosphate (PNP) or the 4'-primary amine of pyridoxamine 5'-phosphate (PMP) to an aldehyde. PNPOx is a homodimeric enzyme with one flavin mononucleotide (FMN) molecule non-covalently bound to each subunit. This domain represents one of the two dimerisation regions of the protein, located at the edge of the dimer interface, at the C-terminus, being the last three beta strands, S6, S7, and S8 along with the last three residues to the end. In Swiss:P21159, S6 runs from residues 178-192, S7 from 200-206 and S8 from 211-215. the extended loop, of residues 167-177 may well be involved in the pocket formed between the two dimers that positions the FMN molecule [2].	20.30	20.30	22.10	21.20	19.50	18.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.45	0.72	-4.46	243	2399	2009-01-15 18:05:59	2008-04-17 13:57:12	4	8	2210	18	735	1792	1629	42.50	54	19.13	CHANGED	WGGaRlhPpplEFWQGpssRLHDRhhY.............p.+..............................................p.ss.s.........WphpRLtP	.....WGGaRltPcplEFW.......QGpt.pRLHDRhhYpR...........................................................p..ss.s.......Wpl.-RLuP................................	1	211	437	608
+10423	PF10591	SPARC_Ca_bdg		Secreted protein acidic and rich in cysteine Ca binding region	Finn R, Coggill P	anon	Pfam-B_3882 (release 22.0), PROSITE_PS00613	Domain	The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2 [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.69	0.71	-4.05	28	665	2012-10-02 16:17:27	2008-04-17 14:18:31	4	31	135	6	337	1603	18	112.60	31	30.93	CHANGED	hssCs-p-LscFspRhRDWlpslhtphhccpptp...........................t..ph.pcsppp.hphhppsltWpFscLDts.tDphLs+pELtsl+usL...hshEpChpsFhpsCDsspDphIohpEWspC	...................................................................................................................................h..sCsst-htphs.RhtDWhpslh.phhpptp.p...............................................................................hp..h.....tp.....pp..h..shppp.sltW.h.F...s.pLDps.tDt...hLs+........pE.L....t....s.....l...c.t...l................sp...E.....+.C......h.............c..........t.............Fh.cpCD.s....s..pDptIohpEWstC..........................	0	74	101	207
+10424	PF10592	AIPR		AIPR protein	Iyer LM, Bateman A	anon	Iyer LM	Family	This family of proteins was identified in [1] as an abortive infection phage resistance protein often found in restriction modification system operons.	25.00	25.00	25.90	25.10	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.03	0.70	-5.10	65	420	2009-01-15 18:05:59	2008-04-17 14:47:42	4	2	382	0	123	388	93	298.40	19	53.89	CHANGED	h-pNVRsaLtsp.........s....VNpuIccTLp...ppPppFhhaNNGITllusclph..sssptt.......hplcshQ.........IVNGuQTosolaps.........tp.ptslsp.......lhV.l+lhhs......ps-....slhscIochsNoQNpVptpDhtupcshppclEphhpshh............haYERtcGpatstpstt....................p.hhspsthtphhssatpcPphsststpphapph.............t.hpphhp..tphst....hatphlshh.llhcthcphlpptt.....................tshstYsl...thhsthhttt.........................................shttlhppp.........plspphhptlhth.spphpchhppsstshtsh	..................................hppNlRsaLsts...........s....VNcsIpcTlp.................ppsptFahaNNGITlls.s..clph..pppst..........hpl.cshp............IlNGuQTssslhps..........................ttttplpp.......shV.l+llth.................psc....phh.spIocssNoQNpVpspDh.t.utcshppplcc.hhppht..............hhYcctcspht.spptph....................thhhsh.sthtp.hh..s..s.h..p.......p.........p.........Pp.h.....s.t.p..ttpphhpph.............t.hpphhs............sphst......hhhphlthh..hlhp....thpphhtptt...........t............................tphhhath......hh..hhttp................................................p..t..tt..............th.tth..p.h......................hh..........................................................................................................................................................	0	40	94	115
+10425	PF10593	Z1		Z1 domain	Iyer LM, Bateman A	anon	Iyer LM	Domain	This uncharacterised domain was identified by Iyer and colleagues [1]. It is found associated with a helicase domain of superfamily type II.	25.00	25.00	25.10	48.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.68	0.70	-5.15	35	212	2009-01-15 18:05:59	2008-04-17 14:51:00	4	3	199	0	78	223	142	234.80	28	28.00	CHANGED	pSLccAlpsFllusAlRplR.....Gt.sscHs................SMLlHsS+hssspcpltshl.pph..lpplcpslpttsstt.........hscL+placpch..................ps.sh.sas-ltstLhpsl....s................s..lclhllN.ussp..-s....LDYssspt.h......ssIslGGspLuRGLTlEGLssSYFhRso+...hhDTLhQMGRWFGYRtsYtDLCRlah..........ot-lhphFpplspssE-LRppl.cphttss.....hTPppaulpVpsps...sLtlT	..........sLccAlhsFllssAl+thR..........Gp...tpc+p.................SMLlHsSphpsspppltphl.pph....hpplppslpttpsts...........hschcplappcht.......................tt.ph.sa--l..h..p.tLhpsl...p.....................s..lplhhlN.ssss..ct.......l-appppt...........tsIslGGspLuRGLTlEGLssoYahRsop...thDTLhQMGRWFGYRts.YtDL..sRlah..........st-lhphFppls.pspp-lRppl.cphtt.ts......hsPhpashplpsp.....h.............................	0	24	58	70
+10427	PF10595	UPF0564		Uncharacterised protein family UPF0564	Coggill PC	anon	UPF0564	Family	This family of proteins has no known function. However, one of the members, Swiss:Q22CP8, is annotated as an EF-hand family protein.	21.10	21.10	21.10	21.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.63	0.70	-5.54	15	182	2009-01-15 18:05:59	2008-04-18 09:08:17	4	5	94	0	110	180	3	304.80	25	51.40	CHANGED	.cITVPpPFphshREpc+pp.t.hpppclcp.hpchpcc..-csEhp++F+ApPVPppVhlP.LYcclhccpEcRRcpl+ccS+thhLps.pKPFpFhtR-cpKcphh.pp.............pcccsppF+A+P...lPcphhtshlpph.....................pEcEhhRppRsphRup-hlps.SphPschtpptpppp.t...............+ptpspppttcpshcsh+s+slPDFccLacsFpcphscp.............KppppsTlscPFshppS.p+sss+cphspts.pht.............................pcsl+tspc................................P................................hpt.p.h.phhcpph.c+.t+pp...cphp.RcKptpchuspsppphpstssspphpcppccphhph+cc.cKpcpcEYpppl	...........................plTlPpPFpMplREtp++t....htp...s..phE..pp.hpcp...t-..c......t....cpp..+pFRApPVPspValP.LYpclhcppEtRRp.hppcp+thLhup..KPFpFht.........+-cpccth...ttpp..th.............tppp.tpt.h+A.+.........l.P+shhtssht-+....................................hpEpEhhRpl+.hphRAt-hLpp..ushP.p.tt..tp.....................................pptc.hs....t..........t..p.h.phps+hpstsPDa-tLhc.papc..phtcp...............+p....+.sTh.scPFp....Lpsu....htt..sp.+tp.h.t..s.httc................................................ppp.p.sph................................................P.....................................s...s..ppttt.pth+pp....pch.t.pt..p.p..h.p.php.p.....h.cp....ht.p.tt.....s.t.p..t................................................................................................................................................................................	0	37	50	76
+10428	PF10596	U6-snRNA_bdg		U6-snRNA interacting domain of PrP8	Coggill P	anon	Chen X	Domain	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [1].	29.80	29.80	30.70	31.80	28.70	29.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.01	0.71	-4.87	11	381	2012-10-03 10:25:13	2008-04-18 15:27:45	4	48	305	0	252	401	3	149.80	76	7.47	CHANGED	FpcYpls+tssahWTpp+HDGKLaN..LpsY+sDhIpALGGlEsILEHoLFKuTtassWEGLFW-K.............sSGFEpoh.Kh++LTNAQRoGLsQIPNRRFTLWWSPTINR..........usVYlGFQlQlDLTGlFMpGKlPTLKISL...IQlFRuHLWQKIHESlVhDLt...QhhDsEh	..............................FKpYQlhKpNPFWWTpQRHDGKLWN...LNsYRTDhIQALGGVEuILEHTLFK...........GThFPoWEGLFWEK.............ASGFEESM.KaKKLTNAQRSGLNQIPNRRFTLWWS.PTINR..........ANVYVGFQVQLDLTGIFMHGKIP..TLK..ISL...IQIFRAHLWQKIHESlVMDLC...QVFDQEL...................	0	89	139	206
+10429	PF10597	U5_2-snRNA_bdg		U5-snRNA binding site 2 of PrP8	Coggill P	anon	Chen X	Domain	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].	21.20	21.20	21.20	21.30	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.65	0.71	-4.57	20	335	2009-09-11 09:17:08	2008-04-18 15:56:36	4	42	290	0	237	321	1	133.60	72	5.89	CHANGED	sppEusWsLhspsTKEpTApAa.LpVSccuIspFcNRlRpILMoSGSoTFoKIAsKWNTsLIuLhTYaREAllsTppLLDlLVKsEsKlQsRVKhGLNSKMPoRFPPsVFYoPKELGGLGMLShGHl.LIPpSDL+aS	...................s.+DGVWsLpNcsTKERTApAF.L+Vs-Eslp+FcNRlRQILMuSGSTTFTKIsNKWNTALIuLhTYaREAsVsTp-LLDlLVKCEsKIQTRlKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHl.LIPpSDLRWS...........	0	88	134	197
+10430	PF10598	RRM_4		RNA recognition motif of the spliceosomal PrP8	Coggill P	anon	Chen X	Domain	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [1]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [2].	23.50	23.50	24.70	24.20	21.80	23.40	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-10.18	0.72	-4.12	25	346	2009-01-15 18:05:59	2008-04-18 16:21:12	4	41	284	0	246	321	7	92.10	69	4.12	CHANGED	EKlDhTLLNRLLRLIlDpNlADYITuKNNVslsaKDMsHlNpYGlIRGLQFoSFlaQYYGLllDLLlLGlpRAsElAG..PsstPNsFhpFpstps	............EKIDLTLLNRLLRLIlDHNIADYhTAKNNVslsYK......DMNHTNSYGlIRGLQFuSFlhQYYGLVlDLLlLGLpRASEhAG..PPQhPN-FLpFpDh.s...........................	0	97	143	207
+10431	PF10599	Nup_retrotrp_bd		Retro-transposon transporting motif  	Wood V, Coggill P	anon	Wood V	Domain	This is the highly conserved C-terminal motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organisms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localisation signal, with two basic peptide motifs separated by an interchangeable spacer sequence, that is crucial for the retro-transposon activity [1].	25.00	25.00	27.50	27.50	18.80	18.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.48	0.72	-3.39	6	66	2009-01-15 18:05:59	2008-04-18 16:42:08	4	6	41	1	25	66	0	97.30	60	7.65	CHANGED	ppuTPsPuSlFsh.GsoNsNhs.........psssPS....osFuFus..shs.......................tstsssSuhssss....hSso..........Ps.....hshGssst.........shssRKIApMR.pR+R	....u.soTPNuSSVFQF.GSS.TTNFNF........TNNNPS....GVFTFGAssSTP.......................AASAQPSGSGuFs....FsQS..........PAu....FTVGSNGKNhFSSSG.TSVSGRKIKTAVRRRK.........	0	3	4	10
+10432	PF10600	PDZ_assoc		PDZ-associated domain of NMDA receptors	Coggill P	anon	Pfam-B_10923 (release 22.0)	Domain	This domain is found in higher eukaryotes between the second and third PDZ domains, Pfam:PF00595, of glutamate receptor like proteins. Its exact function is not known.	21.20	21.20	22.00	22.30	21.10	20.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.44	0.72	-3.68	12	321	2009-09-11 14:48:04	2008-04-23 15:51:39	4	37	37	29	104	277	0	65.50	53	8.76	CHANGED	KPoohahs..DsYuPPDITsSYS.thDNclS.su.lG.......ch.psLsP.sSPsRYSPlPKshLG-DDloREPR	.....KPoohYhs..DsYuPPDITs.S.....aSt.....hDNHlSpsu.LGh.......c...shs.P..sSP..uRY.SPlsKphLG--D.hT.R.EPR................................	0	4	14	41
+10433	PF10601	zf-LITAF-like		LITAF-like zinc ribbon domain	Protasio A, Bateman A	anon	Clustering of trematode sequences	Family	Members of this family display a conserved zinc ribbon structure [1] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [3].	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.05	0.72	-4.11	46	755	2009-01-15 18:05:59	2008-04-24 10:49:46	4	16	214	0	542	755	1	70.80	27	40.68	CHANGED	hpssPs.hhCPpCpppshTplphcsGssTa.........hsshlLhhhh..hsC.shlPashcssKDshHhCPsCsshlGhach	...........h...tPsphhCPpCpppl.......hTpl.phpsGhho.a.................lhsh...h.....l.....slhsh...h.....s.....C....sh...lPhhhss.hp.-spHhC..PsCpthlupap................	0	237	298	446
+10434	PF10602	RPN7		26S proteasome subunit RPN7	Mistry J, Wood V	anon	Pfam-B_4112 (release 22.0)	Family	RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity [1].  The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.	29.40	29.40	29.40	29.50	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.75	0.71	-4.89	63	673	2012-10-11 20:01:02	2008-04-24 12:50:55	4	12	331	0	453	671	11	171.80	30	40.18	CHANGED	DpshhcphppcNppclpcL-pclcchc.cNhscp-l+puhhchu-aYtclGDhcpAlcsapc.sh-hssusup+lDhhhsllRlulahsDhshVpphlp+Acshh-p..uuD........................................W-p+NR..............................LKsYpGlhtlshRcacpAAphhL-ohsTFsu......sElhoapslshYuslsulhoh-Rs-L+pK	...........................................DpshhpphpcpsptclccL-pclc......shc..pNhhc.pplR............p..uh.chu-aahclG.Dh.............psA.................lcsap.............+..sh....-.h....s....s..uhsphl-hshpll+l....ulaht.Dhsh.lp.pt..lpKAc...shh-p..usD.................................................................................hc.p.+s+..............................LKsh..pGLhplu.h....R...sa+pAAph..........FL-s..h...ssass.................hELhshpslshYsslsulhoh-Rs-L+p................................................	0	160	250	371
+10436	PF10604	Polyketide_cyc2		Polyketide cyclase / dehydrase and lipid transport	Lakshminarayan L, Mistry J	anon	Manual	Family	This family contains polyketide cylcases/dehydrases which are enzymes involved in polyketide synthesis. It also includes other proteins of the START superfamily [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-11.10	0.71	-4.01	179	5359	2012-10-02 19:24:03	2008-04-24 14:10:18	4	67	1547	79	1946	8699	1599	142.00	13	81.08	CHANGED	thplpps......h....pls.ussppVashlsD...h..sshs......p....W......ts..slh...ps..p......h.s...t...sss......................hh....tthp.hsu..........................lppplsp..h....c.s....tpthsach...............hsht...ph..tss.hplps...ss..s.......G.....sp..ls...ash......pht......................shh.............t.h........ht....thlpsh....hpt.sLppLppthc	...................................................hptsh.tl..s..AssppVa.s...h...l.sD.......h..p.ph.s.......p..........W............hs....tlp........ps.......c..........hh....p.......sss......................................th......t..php..hsu.....................ht..........................h.p..p..p......l..h...p......h.............c...s...........sp..t..l.s..aph............................hsht.....ph...t......sp..h..pl..ps........ts.......s................G..............op....lp...........hph........p.hp...............................s.h....................t..h.........ht......thhp...t...........hpt.s....lptLtt................................................................................................................................	0	564	1317	1714
+10437	PF10605	3HBOH		3HB-oligomer hydrolase (3HBOH) 	FIGFAMs, Mistry J	anon	FIG094011 (Release 2.0)	Family	D-(-)-3-hydroxybutyrate oligomer hydrolase (also known as 3HB-oligomer hydrolase) functions in the degradation of poly-3-hydroxybutyrate (PHB).  It catalyses the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers.	25.00	25.00	27.00	25.30	23.40	24.90	hmmbuild  -o /dev/null HMM SEED	690	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.44	0.70	-13.16	0.70	-6.45	13	134	2009-12-10 17:34:17	2008-04-24 14:14:15	4	3	127	0	41	138	14	584.70	48	90.33	CHANGED	lsluACsGussssss.....................hNs+PuFl..GsVphpuYDGsoDDLLTAGLGKoGLuSATAPuhAsPssPTAAELRRLAIasNYRALVDsousGGYGoLaGP..NVDAsGssTs.G-GKIAGsEYlAYuDDGoGppNVTlhVQVPsoFsPspPCIVTATSSGSRGVYGAIuouGEWGLK+GCAVAYTDKGTGsGsHDLsTsTVsLIDGTRsstsuAGpsutFsAsLuAss.LAsFNuuhPpRhAaKHAHSQQNPEpDWG+hTLQAlEFAaasLN-paGstsssGts..hplpPusslVIASSVSNGGGAAlAAAEQDTcGLIDGVAVuEPplNlssssulsV+RGusP.lsusG+sLhDYsThANLLQsCAAlAsuhss.APhtsshsss......sltsNRCsoLsApGLloGuTTusQAssALstLct.sGapPESslLpAShashpsssuIAVTYANAYuRASVpDpLCsaSFAuTsAsss.....ssshusushAolFusGNGlPPTsGlsLVNssutG.sPh.shsSlS.usup.DhNl-GALCLRsLhoGsDus............u.tlppGlsplptoGNLpGKPAlIVpGRuDALlPVNHTSRPYlGLNptsEGusS+LSYlEVTNAQHFDAFlG....lPGYssRaVPLHhYhhQALDhMYupLpsGsPLPPSQVVRTlPRGGssu..sAPslosANVPPIssoPuAuDtIslssu....sVsVPD	.........................s..huuCtus.psst.....................hNthPu.al..GsVphssY.........DG.........soDDLLTAGLGpoGLuusosPuhAsPspPTAAELRRlAIauNYRALVDhossGGYGphaGP..NVD.h...s.GssTh.G-GhIsGsEYlAauDDGoGppNVollVQlPsoFssspPCIlTATSSGSRGlYGAIus.GEWGLK+GCAVAYsDKGsGsGsH-luossVsLlDGThsstssAGssuhFsAshosu.p.LAAFNuthPNRhAaKHAHSQpNPEpDWGp.TLQAlcFAaasLN..-pa.Gshs.......ss..st.p..hphpssshhsIAuSVSNGGGAulAAAEQDs....p...GhIsuVsVuEPplNl......ssshs.VppGGss..lsshG+PLhDYsThANLhpsCAAhusu..h..ss..uPh.huhh.shsh....tuhtspRCAsLt..AtGLloG..ussssQAs-.....ALtpLcs.hGa.s-SDhlpAshhs.ps.PulAsTYANAYsRupVpDNLCsaSFAsssssss.....ssssssushsshFusGNGlPP.TsGlpLl.Nsu.....tG........uls.phus.DhshsGAhCLRpLhTus...................thultsulstlthsuNLpGKPAIIVpGRuDALlPVNHuSRsYluhNptsEGtt.SpLsahEVsNuQHFDuFls...........lPGaDTRFVPlHhYt.pALshMasaL+s.GsPLPPSQVlRTlPRGGssG..uAPAlosANlPslstsPuA.stIssssu....slsVP...............................	0	4	16	29
+10438	PF10606	GluR_Homer-bdg		Homer-binding domain of metabotropic glutamate receptor 	Coggill P	anon	Pfam-B_17370 (release 22.0)	Domain	This is the proline-rich region of metabotropic glutamate receptor proteins that binds Homer-related synaptic proteins. The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich "Homer ligand" (PPXXFr). Activation of PI turnover triggers intracellular calcium release [1]. MGluR function is altered in the mouse model of human Fragile X syndrome mental retardation, a disorder caused by loss of function mutations in the Fragile X mental retardation gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners [2].	25.00	25.00	26.50	25.80	18.30	18.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.73	0.72	-4.07	5	118	2009-01-15 18:05:59	2008-04-24 14:35:50	4	4	37	1	60	89	0	50.30	66	5.05	CHANGED	ALTPPSPFRD.SVuSGSSsPu.SPVSESlLCsPSNspYsSlIL+DYoQSSSTL	....ALTPPSPFR.D.SVsSGSosPs.SPVSESsL..........C..........h.PssspYsolIlRDYsQSSSoL........	0	2	8	30
+10439	PF10607	CLTH	RanBPM_CRA;	CTLH/CRA C-terminal to LisH motif domain	Coggill P, Bateman A	anon	Pfam-B_3765 (release 22.0), UPF0559	Domain	RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system.  This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined [5]. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif [6].	23.00	23.00	23.00	23.00	22.80	22.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.68	0.71	-4.50	132	1458	2009-01-15 18:05:59	2008-04-24 14:51:03	4	27	290	0	1000	1417	5	169.80	20	40.24	CHANGED	hhtphpcIhcsl..ptclppAlpWssc..............................ppspLhch......p...........................ssLc.FcLph.paIELl+................p......................................................................................................................................sp..................................hhcAlpau+c......pl.s...hsp...........................t....hhp-lpphhuLLsats....................................................................pshpp.......................Lhss.pp..............hpplsppFspsh..hphh..shs.......p........ps........................LthhlpsGh.ulpshh	...............................................................................................h.ptpcItctl.tps.p.lppAlph.s..pp..........................................p.s.p..Lhcp..........s.....................................................................................................ssL...FpLpp.p.a.lELl+...............s......................................................................................................................................................................................................................................................................................................................................................................sp...............................................hp..cAlpaupp...........pl..s......hsp...............................phhc-.l.p.c.s.huLL.sa.ssstp.......................................................................sshtp......llss..pp.................hpplssthspsh...h.phh...shs...........p...........ps........................Lthhlptsh.sh....h.............................................................................................................................................	0	321	541	796
+10440	PF10608	MAGUK_N_PEST		Polyubiquitination (PEST) N-terminal domain of MAGUK	Coggill P	anon	Pfam-B_18049 (release 22.0)	Domain	The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination [1]. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerisation of the whole protein [2].	21.60	21.60	23.00	21.80	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-10.03	0.72	-3.58	14	339	2009-01-15 18:05:59	2008-04-24 15:02:41	4	33	36	21	110	279	0	70.70	44	10.98	CHANGED	p+YRYQD--os.P.E......pSssplsscshssELlclu-K..sluph-Nl.......HGaVsHsHISPh..................................................pAsssPllVNT-oL-sssY...VNGT-s-aEaE	..............................................tYth.spps...P.p.........s.hstt......................................sh..p..hosh...................................................pAsss..PllVNTDoL-sssY.........VNGT-u-hEYE.................................................	0	5	15	41
+10441	PF10609	ParA		ParA/MinD ATPase like	Mistry J, Wood V	anon	Pfam-B_177 (release 21.0)	Family	This family contains ATPases involved in plasmid partitioning [1].  It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits [2].	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.68	0.72	-4.10	250	4990	2012-10-05 12:31:09	2008-04-24 17:05:32	4	43	4013	3	1687	4768	2898	81.20	48	23.71	CHANGED	LDYLllDhPPGTGDhp.LolsQpl..........s..............ls.......Gul.lVTTPQ-l..........AlhDscKulshh..c+hslPllGlVENM......ShahCPp.C.....ucppplFG..pG	..............................LDYLllDhPP..G..T.G..Dl.p.LolsQpl...........P..................................ls....Gu..llVTTPQcl.................AlhDA...cKuls.Mh..c..K...l......p.l..P.l.L.........GlV.E...N.M......S...h..a..hCss..C.....Gcc..ptlFGp...........................................	1	591	1076	1434
+10442	PF10610	Tafi-CsgC		Thin aggregative fimbriae synthesis protein	FIGFAMs, Mistry J, Coggill P	anon	FIG009025 (Release 2.0)	Family	Fimbriae are cell-surface protein polymers, of eg. E coli and Salmonella spp, that mediate interactions important for host and environmental persistence, development of biofilms, motility, colonisation and invasion of cells, and conjugation. Four general assembly pathways for different fimbriae have been proposed, one of which is extracellular nucleation-precipitation (ENP), that differs from the others in that fibre-growth occurs extracellularly. Thin aggregative fimbriae (Tafi) are the only fimbriae dependent on the ENP pathway. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. Tafi are known as curli because, in the absence of extracellular polysaccharides, their morphology appears curled; however, when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix. The gene agfC is found to be transcribed at low levels, localised to the periplasm in a mature form, and in combination with AgfE is important for AgfA extracellular assembly, which facilitates the synthesis of Tafi. The genes involved in Tafi production are organised into two adjacent divergently transcribed operons, agfBAC and agfDEFG, both of which are required for biosynthesis and assembly [1].	25.00	25.00	26.80	26.60	22.20	20.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.53	0.72	-4.21	2	412	2009-01-15 18:05:59	2008-04-24 18:01:26	4	1	407	3	12	89	0	103.40	84	92.46	CHANGED	LLLAALSSQITFNTTQQG-lYTIlPpVTLopsClCcVQIhulR-GpuGQSpTpQcpTLSLPANQPIsLT+LSLNISP-DpVKIlVTVSDGQSLHLSQQW.PSsEKS	...................LLLAALSSQITFNTTQQGDlYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISP-DRVKIVVTVSDGQSLHLSQQWPPSSEKS......	0	1	3	7
+10443	PF10611	DUF2469		Protein of unknown function (DUF2469)	FIGFAMs, Mistry J	anon	FIG004032 (Release 2.0)	Family	Member proteins often found in Actinomycetes clustered with signal peptidase and/or RNAse-HII.	25.00	25.00	29.00	137.90	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.36	0.72	-3.65	12	430	2009-09-11 15:00:03	2008-04-25 09:17:54	4	1	430	0	109	192	35	101.10	69	98.07	CHANGED	MSAEDLEpYEoEMELpLYREYRDVVGlFpYVVETERRFYLsNpV-lpsRoss.G-VYFEVoMsDAWVWDhYRPARFVKsVRVlTFKDVNlEELsKs.-l.-lPc	..MSAEDLEpYEs-MELsLYREY+DVVG.FoYVVETERRFYLANsV-lpsRs.s.s.G-VYFEVphuDAWVWDMYRPuRFVKpVRVlTFKDVNIEE.lsKs.Dl.clPp......	0	33	80	101
+10444	PF10612	Spore-coat_CotZ		Spore coat protein Z	FIGFAMs, Mistry J, Coggill P	anon	FIG014057 (Release 2.0)	Family	This family has members annotated as Spore coat protein Z, otherwise known as CotZ, It is a cysteine-rich spore coat family, and along with CotY is necessary for assembly of intact exosporium.	19.90	19.90	20.40	21.00	18.30	17.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.82	0.71	-11.46	0.71	-4.34	11	223	2009-01-15 18:05:59	2008-04-25 11:28:31	4	2	119	0	21	136	0	148.80	56	93.76	CHANGED	MSCsppcth.......tspNCVs-sVctIc-LQ-us..--..sCsTuCasshLu..sos...shuDThPFlLaTKpGsPFpA...Fu.ssuplsss...Ch.SsFFRVEslcD.sCAsLRVL..........pshststshLchs-ps..........lCps..............hcLcKTshCIpVDLsCFCAIQCLssphl	......................MSCNpNccH.......ss.sCVssVV+FIpELQ-Cu..TT....TCGSGCEl...PF...LG...AHNsA..SVANTRPFILYTK....sG.sPFEA.....FA..PSusL..suCc......SPIFRVESlDD.D..s.C.AVLRVL...................oVVLGDs...osVPPsDDP................ICTFLu.........VPNARLlSTsoCITVDLSCFCAIQCLRDVoI........	0	4	11	13
+10445	PF10613	Lig_chan-Glu_bd		Ligated ion channel L-glutamate- and glycine-binding site	Coggill P	anon	Pfam-B_203 (release 22.0)	Domain	This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.	20.30	20.30	20.30	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.10	0.72	-3.99	82	1132	2012-10-03 15:33:52	2008-04-25 14:02:08	4	36	106	435	539	1967	2	64.60	46	8.17	CHANGED	PasM.h+ps.......h...tuspp.aEGaClDLlcclAchl.sFsYcltlV.tDG..pYGshpp..sG.........pWsGhlGELlp	..................................PYVM.h+cs.......tp.h...pGN-R..aE...GYC...lDLlp........E..l......Ac..h......l......G.......F.......p...Yc.l.plV...sDG.............KYGup-s...ss...................pWN.GMVGELl...................	0	155	196	354
+10446	PF10614	CsgF	Tafi-CsgF;	Type VIII secretion system (T8SS), CsgF protein	FIGFAMs, Mistry J, Coggill P, Desvaux M	anon	FIG077109 (Release 2.0)	Family	The extracellular nucleation-precipitation (ENP) pathway or Type VIII secretion system (T8SS) in Gram-negative (diderm) bacteria is responsible for the secretion and assembly of prepilins for fimbiae biogenesis, the prototypical curli. Besides the T2SS that can be involved in the assembly of prototypical Type 4 pilus, the T4SS that can be involved in the biogenesis of the prototypical pilus T, the T3SS involved in the assembly of the injectisome and the T7SS involved in the formation of the prototypical Type 1 pilus, the T8SS differs in that fibre-growth occurs extracellularly. The curli, also called thin aggregative fimbriae (Tafi), are the only fimbriae dependent on the T8SS. Tafi were first identified in Salmonella spp and the controlling operon termed agf; however subsequent isolation of the homologous operon in E coli led to its being called csg. In the absence of extracellular polysaccharides Tafi appear curled, although when expressed with such polysaccharides their morphology appears as a tangled amorphous matrix [2]. CsgF is one of three putative curli assembly factors appearing to act as a nucleator protein. Unlike eukaryotic amyloid formation, curli biogenesis is a productive pathway requiring a specific assembly machinery [1].	25.00	25.00	29.70	29.60	24.30	18.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.69	0.71	-4.19	6	534	2009-01-15 18:05:59	2008-04-25 14:25:13	4	2	527	0	56	165	266	127.60	69	95.73	CHANGED	h+hhGl..hAhLlhhtA..ussApAusLVYpPhNPsFGGsPhNuuaLhupANAQNphpcsstsss.............ps.Spu-hFApQLQoQLLSuLusQlspAIFG-ssQcuGshoFsupoloas+sssslslsIsDssTGpsTpIsVP..ss	......................hl...........l.hhhh....SP.LoWAGsMTFQFRNPNFGGNPNNGAFLLNSAQA.QNSYKDPSY.s-DFGI..........ETPSALDNFTQAIQSQILGGLLoNINTG..............K..P.....GR...........MVTNDaIVD.IA.N.R.D.GQ.LQLNVTDRKTGpTSTIpVSGLQs......................	0	12	22	37
+10447	PF10615	DUF2470		Protein of unknown function (DUF2470)	FIGFAMs, Mistry J, Coggill P	anon	FIG076093 (Release 2.0)	Family	This family is a putative haem-iron utilisation family, as many members are annotated as being pyridoxamine 5'-phosphate oxidase-related, FMN-binding; however this could not be confirmed.	21.00	21.00	21.00	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.98	0.72	-3.76	50	682	2009-01-15 18:05:59	2008-04-25 15:11:28	4	12	625	9	274	592	273	81.30	25	33.83	CHANGED	tuDPlsst...susplspHMNsDHu-AlhtYAptauGl.....sss...ssA.......pMtul-spuhcLpl.............ss.tslclsF-ps.......Lsssp-s+psLVtMs	.................................h............tppllpHMNs-Htcsltths.c..p.a..ush...........tps...........pss..........................phhulDhpGlclth...........t...............sp.pslRl.Fsp.........ss.-.ps.l+psllth...................................	1	87	181	241
+10448	PF10616	DUF2471		Protein of unknown function (DUF2471) 	FIGFAMs, Mistry J, Coggill P	anon	FIG076041 (Release 2.0)	Family	The function of this family is unknown. Members all come from Burkholderia spp. Swiss:A2WH83 is annotated as Serine/threonine-protein kinase, but this could not be confirmed.	25.00	25.00	31.20	31.00	22.30	18.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.56	0.71	-3.93	7	81	2009-01-15 18:05:59	2008-04-28 11:07:54	4	1	56	0	27	68	4	122.40	49	95.15	CHANGED	spp.slsslpFcpAAc....DLc+IVtpIAtRYlspt........VslTWphLhsIEtEAhuDLGFtSRpDushlshF.R.ushphPtsD..-hlDasp.ossLPAVathshsthEpsu.cA.pp................Ahss	...................p-psLAALpFcsAA+....DLEpIVppIApRYIpQp........VPLTWRLLHAlEAEALADLGFASRHDshlhsLFpRPu-hcaPETD..DsVDFGp.SsALPAVFuFAVuAYEtAA.c.sttp...sst................	0	1	5	13
+10449	PF10617	DUF2474		Protein of unknown function (DUF2474)	FIGfam, Mistry J, Coggill P	anon	FIG073099 (Release 2.0)	Family	This family of short proteins has no known function.	24.80	24.80	24.90	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.92	0.72	-4.36	18	344	2009-01-15 18:05:59	2008-04-28 11:30:32	4	1	323	0	76	225	3	39.40	44	83.46	CHANGED	ppshW.pRLuWLllIWuuSVhALGlVAhlhRLhMsAAGLpo	......h...hW.+RlsWhlsIWsuSVLsLusVuhLhRllMsuAGhpo.....	0	6	24	51
+10450	PF10618	Tail_tube	DUF2473; 	Phage tail tube protein	FIGfams, Mistry J, Bateman A	anon	FIG030252 (Release 2.0)	Family	This bacterial family of proteins contains phage tail tube proteins related to the Mu phage protein Swiss:P79679 [1]. Bacteriophage Mu has an eicosahedral head and contractile tail. The tail is composed of an outer sheath and an inner tube.	21.60	21.60	21.90	22.00	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.01	0.71	-4.37	24	282	2009-01-15 18:05:59	2008-04-28 12:44:06	4	1	261	0	33	148	1	116.70	36	98.55	CHANGED	Mut..plsGsshl+lsGt.plpspsu.sphs.ushpREslhG..stlhGapEp.p.sshlcsslhsstshs..ltclsshsshTlohEhsNGpsYllssAahs-s..sspsc-GplslpacGppsph.	.............u..+luGTsal+lDGp.pLslsG.G.hchshsshtR-slhGh.sushsa.KEo.+.APalcsohpsstshs..lscIs.stsshTIs.sE.huN..GpsYlhosAWhtsps..shss--GTl-.lcFcGppush.........	0	6	14	25
+10452	PF10620	MdcG		Phosphoribosyl-dephospho-CoA transferase MdcG	FIGfams, Mistry J	anon	FIG003211 (Release 2.0)	Family	MdcG is a phosphoribosyl-dephospho-CoA transferase that is involved in the biosynthesis of the prosthetic group of malonate decarboxylase [1].  Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage. MdcG catalyses the following reaction: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + apo-[acyl-carrier-protein] = holo-[acyl-carrier-protein] + diphosphate.	26.10	26.10	26.40	45.10	22.10	25.60	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.39	0.70	-4.80	47	349	2012-10-02 22:47:23	2008-04-28 15:00:13	4	2	315	0	97	355	6	191.60	29	95.30	CHANGED	M.....................p.HDLlalpssu....hh.......ssss.shltshh.....tsuhPlVVRRs.s....sssGtlslGlth.....tspcp..RhuhhlssssltcshsP.sLsph.......hst..tshsh.htslps.L.s.s.ssh....shshtlhGSsuap......................hhTGlshlpssSDLDLllps.sssh...phpplhphLt...ppts.hRlDsplphPsG.uVuh+Ehtssss.....pVLlKstcGspLhsps..a	......................................t.HcLlhhts.s....hh...................s.st.taltthh.....ttuhPllVRRs.s....sssstlslGlps.....ttppp..RhAh.hshssltphhsP.sLsph.........tt...tsh.sh..h.slpt..ltshh.pth....shshGlhGShuap......................hsTGlshlpss....SDLDLL.lps.spsh........phtthlphl...tt.h.tphs.hRlDspl.hs.p.G.uhuh+Eahtsst.............plLlKospGspLhtss..................	0	13	40	66
+10453	PF10621	FpoO	zf-Fe2-S2-FpoO; 	F420H2 dehydrogenase subunit FpoO 	FIGfam, Mistry J, Coggill P	anon	FIG062058 (Release 2.0)	Family	This is the FpoO subunit of F420H2 dehydrogenase, an enzyme which oxidises reduced coenzyme F420.  Reduced coenzyme F420 is a universal electron carrier in methanogens.	25.00	25.00	45.10	45.00	20.20	22.50	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.66	0.71	-4.03	3	11	2009-09-11 06:40:42	2008-04-28 16:08:27	4	1	10	0	9	10	0	103.40	43	94.51	CHANGED	MTDCDLCG+AIPTVIPVRVFRPRLKFAYPEGVWKGLCEuCLDSAQKTYLElNKcpsSCR+GKCsLCGcKTpVaPVElQVPDFSKGlVlKcVclChKCL-ulsEoYIRaKKEQIE...CEHGH	.............MsDCDLCGhulPTlhPVRVhtPhhchuYPEGVWKGLC-sCL-SApcTY.Eh..scspsus....ppGKCsLCGs+stlasVElplPsFpps...cshplChpCLc.spEsa...h+-....................	0	1	6	7
+10454	PF10622	Ehbp		Energy-converting hydrogenase B subunit P (EhbP)	FIGfams, Mistry J	anon	FIG124174 (Release 2.0)	Family	Ehb (energy-converting hydrogenase B) is an methanogenic archaeal enzyme that functions in one of the metabolic pathways involved in methanol reduction to methane.  This family contains subunit P of Ehb.	19.50	19.50	20.60	118.80	18.70	19.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.70	0.72	-4.03	6	26	2009-01-15 18:05:59	2008-04-28 16:16:51	4	1	26	0	17	23	5	84.10	58	91.35	CHANGED	LhP+hhhuLGGYIhET...........pFPaRNlIVsNPTsEPIKIEVPsaD-pWIEcH+cLGLhVVPVs-DDDFluha+MsccKlc+u	.LLPKhsMSLGGYIRETh.......t..pFPYRNlIVGNPTsEPIKI-VPsYDEsWIE+H+cLGLIVVPVpc-DDFVGlF+hVcpKlcc....	1	3	7	13
+10455	PF10623	PilI		Plasmid conjugative transfer protein PilI	FIGfams, Mistry J	anon	FIG136100 (Release 2.0)	Family	The thin pilus of plasmid R64 belongs to the type IV family and is required for liquid matings.  pilI is one of 14 genes that have been identified as being involved in biogenesis of the R64 thin pilus [1].	19.70	19.70	19.80	26.20	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.83	0.72	-4.05	2	72	2009-01-15 18:05:59	2008-04-28 17:04:57	4	1	62	0	0	21	0	80.10	63	92.57	CHANGED	Mstp...+hplllhsspCc++l..h.sspD.s.hhh.FpTsDNsLllVhpssRhlhRhERhPGSpCcW+cso.u.+p+.ps.L	......MPQQHPGRLQlLVVDsHCKR+LFSTKTsTDPDELARRFCTPDNCLVVVLpsNRFLFRLERAPGSHCR..W+KGSpSRHQHLQDWL.......	0	0	0	0
+10456	PF10624	TraS		Plasmid conjugative transfer entry exclusion protein TraS	FIGfams, Mistry J	anon	FIG105028 (Release 2.0)	Family	Entry exclusion (Eex) is a process which prevents redundant transfer of DNA between donor cells.  TraS is a protein involved in Eex.  It blocks redundant conjugative DNA synthesis and transport between donor cells, and it is suggested that TraS interferes with a signalling pathway that is required to trigger DNA transfer [1].  TraS on the recipient cell is known to form an interaction with TraG on the donor cell [1].	25.00	25.00	42.70	31.60	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.24	0.71	-4.68	2	81	2009-01-15 18:05:59	2008-04-29 14:53:22	4	1	66	0	1	44	0	147.20	75	98.09	CHANGED	MKNLApIsLVTVlQFIACYLA-WGsAETshILhFllLWQGLFIWLF.QIRKKpplSDEFKFSKGlWYllMPVsSLLSPLLSLMlFIhGTLYELRRlSGClSl+EWhpsQls-QhsEDhtLDF-sVpac.ssaY..NPuTGhsMHGGhDSAGNTFGopWQD.sDR	...................M+sLsHIsLVTVIQFIACYLAsWGsAETlFhLhFIVLWQGLFIWLFSQI..RKKRsVSDEFKFSKGVWYIhMPVSSLLSPLLSLMVFIIGTLYELRRVSGClSl+EWMQSQVN.EQsNEDLHLDFDslp...sDFYRTNPATGLPMHG.GhDSAGNTFGosWQDYsDR.....................	0	0	0	1
+10457	PF10625	UspB		Universal stress protein B (UspB)	FIGfams, Mistry J	anon	FIG002192 (Release 2.0)	Family	UspB in Escherichia coli is a 14kDa protein which is predicted to be an integral membrane protein.  Overexpression of UspB results in cell death in stationary phase, and mutants of uspB are sensitive to ethanol exposure during stationary phase [1].	25.00	25.00	61.00	60.80	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.47	0.72	-4.27	8	648	2009-01-15 18:05:59	2008-04-29 16:18:06	4	1	646	0	50	149	0	97.70	80	96.31	CHANGED	MISGDsILhALhlVTslNhARYlSoLRsLLalMR-ucPLLYQQVDGRGFFTTHGNhoKQlRLapYI+opEYLcHHDPlFstKC-RVRcLFILoSuLlulsllshFhl	.MISs.slhaALhlVshlNMARYFSSLRALLVVLRsCDPLLYQYVD.GGGFFTSHGQPNKQVRLVWYIYAQRYRDHHD-EFIRRCERVRRQFILTSALCGLVVVSLIAL.....	0	2	11	30
+10458	PF10626	TraO		Conjugative transposon protein TraO	FIGfams, Mistry J	anon	FIG055244 (Release 2.0)	Family	This is a family of conjugative transposon proteins.	25.00	25.00	26.10	25.90	20.20	22.20	hmmbuild  --amino -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.94	0.71	-4.86	11	300	2009-01-15 18:05:59	2008-04-29 16:58:48	4	1	111	0	28	251	2	162.60	48	87.16	CHANGED	LPGMKGlplTuGM..sDGh+h.pscs-hGYtFGlAhoTYsKssN+WVhGuEYLpKpaPY+shpIPluQFTuEGGYYashLSDssKshFlslGhSALuGYEoVNhGcpLL.DGusLpcpDuFIYGGAlTLEhEsYLoDRllLLlpsRERsLaGoDsG+FHsQaGlGlKhIl	................LPt.+GlElpuuh..s-Ghp...ststhsYthGhAlosYsKpuNpWlhGuEYlp+phsY.....+s.......hpI..PltQFTuEGGYaaplLSDspKslFlhhGhSALAGYEol.NhGcKlL.DG..uTLtc+DsFlYGGAlTL-lEsYLoDRlsLLhpsRERhLaGuDst+FHsQhGlGlKFhl................................	0	7	24	28
+10459	PF10627	CsgE		Curli assembly protein CsgE	FIGfams, Mistry J	anon	FIG091002 (Release 2.0)	Family	Curli are a class highly aggregated surface fibres that are part of a complex extracellular matrix.  They promote biofilm formation in addition to other activities.  CsgE is a non-structural protein involved in curli biogenesis [2].\	      CsgE forms an outer membrane complex with the curli assembly proteins CsgG and CsgF [1].	25.00	25.00	35.50	27.90	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.06	0.72	-4.23	20	509	2009-01-15 18:05:59	2008-04-29 17:28:52	4	1	505	0	44	135	11	103.40	76	77.48	CHANGED	ElsGLllDRTloRhG+DFYhhFSsta+-ls..stshNLolcEpssupuGShlsVphspcsIYpTalu.pppslccpAppAlthVhptlsphphpt.....sosDLu..pDEh	........EVPGLLTDHTVSSIGHDFYRA..FSDKWES-Y....TGNLTINERPSARWG.S.WITITVNQDVIFQTFLFPhKRDFEKTVVFALlQTEEALNRRQIsQuLL..STuDLA+DEF............	0	8	16	31
+10460	PF10628	CotE		Outer spore coat protein E (CotE)	FIGfams, Mistry J	anon	FIG006437 (Release 2.0)	Family	CotE is a morphogenic protein that is required for the assembly of the outer coat of the endospore [1] and spore resistance to lysozyme [2]. CotE also regulates the expression of cotA, cotB, cotC and other genes encoding spore outer coat proteins [1].  The timing of cotE expression has been shown in Bacillus subtilis to affect spore coat morphology but not lysozyme resistance [3].	25.00	25.00	28.60	78.40	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.22	0.71	-4.91	9	180	2009-09-11 05:35:09	2008-04-30 14:11:34	4	1	178	0	35	94	1	178.80	59	98.44	CHANGED	MuE......YREIITKAVVuKGRKFTpuoHTIoPsc+PoSILGCWIINHpYcA.+KsGKsVElpGpYDINVWYSYscNTKT-VVTEpVpYsDllpLpYRDcssl.sD-h-VlA+VlQQPNCLEAsISssGsKIhVpVEREFlVEVIGETKVsVuVNPpspp-D.s....hph-hpD-EhE-lsPsFLtsppEE	.....MSEaREIIT.KAVVGKGR.K.aTp..STHTspsssc..P.T.SILGCWlINHpY......EA......+Ks......GKpVEI-GaYDVNsWYSacsNTKTEVVTERVsYsDpVslsYRDc.N.ap.uDDhElIARVIQ.PNCLEAhlSPNGNK..IVVpVEREFlsEVVGETKlCVuV..N..P-..Gss.-.sD-........-...apl..t.D..-EaE-LDPsFlV-s.E.............	0	13	25	27
+10461	PF10629	DUF2475		Protein of unknown function (DUF2475)	Coggill P	anon	SWISS-PROT(UPF0573)	Family	This family of proteins has no known function.	21.60	21.60	21.80	21.70	21.00	21.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.44	0.72	-3.73	19	290	2009-01-15 18:05:59	2008-04-30 14:19:30	4	7	77	0	189	287	0	56.90	28	33.47	CHANGED	sPthlPGYpGasPthtaphGp..TYGpsTtphhps.pstt.tp.h.............h.p..t.ssphhlspR	......thlPG...YsGasPth..+..ap..hGp..TYGpsTtphh..tt......t...................................t.....................................................	0	73	91	134
+10462	PF10630	DUF2476		Protein of unknown function (DUF2476)	Coggill P	anon	SWISS-PROT(UPF0572)	Family	This is a family of proteins of unknown function.\	\	\	    The family is rich in proline residues.	21.70	21.70	21.70	35.10	20.40	21.50	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.88	0.70	-4.51	3	61	2009-01-15 18:05:59	2008-04-30 14:48:06	4	3	21	0	35	65	0	234.80	48	96.78	CHANGED	M.GoRPsSPSADLAPhWu.QssGPoPAKRsRL.pEPAsPEsLAQPu.EDPA.....-shTShVhLsAGsALclPL-sVDLlLElpPhSVLpVSLQGHTlI..llPEsLtSSV.-hsht.tcuQPGh.s.s..GAtupD......VslppEoFCAsV.EhhhpE-ss-EDADsEFsEhWMsuPDDpAsGLasSusSl.SPhp-GQVPGPso.ussPuAEppSPRFIW-L-hsMLcPlPuSPLQPLPPSPSPNPQEQs.....LPsRPPC......KARRRL	...................................M.GoRPRSPSAp.sAPhWu.QPuGPu.PAKRhRL..cEP..AssEsh..ssPshEs..Pss..ssssLTS..lVVLuuGCALplsL-.-VDLVLEPtPTSlLpVSLsG..H..TLI..LlPEsLLuSs...tts.spssussGLEss.shLuA..tc-......Vllppt.FCuuVPElAsQE-A..h.-EDA..-spF.p.hhsussGpAuGL..asS..s..p..uh.uP..h.pu.hst.Pps...sssPusEppSPp.sha-L-h+LLEPhPoSPLQPLPPSP...S..PG.Pptcs...........hPt.pP......P...C......KARRRL.......................................................................	0	4	4	15
+10463	PF10631	DUF2477		Protein of unknown function (DUF2477)	Coggill P	anon	SWISS-PROT(UPF0574)	Family	This is a family of proteins with no known function. The family is rich in proline residues.	20.60	20.60	20.80	87.60	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.15	0.71	-3.96	3	22	2009-01-15 18:05:59	2008-04-30 17:09:40	4	1	20	0	12	26	0	135.90	75	92.45	CHANGED	MDPHEMVVKNPYAHISIPRAHLRPDLGQQLEsuPosSSSSEoQPLPVGoCsPEPltLLQsTEAPGPKGsKG.pGsAP.psQQAWQQPCNPYSSGQRPAGLTYAGPPPAGRGDDIAHHCCCCPCCSCCHCPRFCRCHSCCCl	MDPpEMVVKNPYAHISIPRAHLRPDLGQQLEsAss..oSSsEhQPLPsGsCssEPT+LLQPT.EsP.GPKG...s...KGspGAsPhQsQQAWQQPGNPYuSuQRPAGLT...YAGhPPlGRGDDIAHHCCCCPCCpCCHCP.FCRCHSCCCl.	0	1	1	1
+10464	PF10632	He_PIG_assoc		He_PIG associated, NEW1 domain of bacterial glycohydrolase	Naumoff D, Coggill P	anon	Pfam-B_97991 (release 22.0)	Domain	The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW1 but its actual function is not known. It is found on proteins which are bacterial galactosidases [1]. The domain is associated with the He_PIG family, Pfam:PF05345, a putative Ig-containing domain.	25.00	25.00	25.90	25.10	22.70	21.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.56	0.72	-7.11	0.72	-4.62	4	47	2009-09-11 10:36:46	2008-05-06 14:04:35	4	5	32	0	17	47	0	28.80	58	4.97	CHANGED	PpINsP+slGNYPuoPFLFYIPTSGpRPM	P+INuPpVhGspPuoPFLahIPsoGpRPM	0	11	14	17
+10465	PF10633	NPCBM_assoc	NPCBM-assoc; 	NPCBM-associated, NEW3 domain of alpha-galactosidase	Naumoff D, Coggill P	anon	Pfam-B_97993 (release 22.0)	Domain	The English-language version of the first reference can be found on pages 388-399 of the above. This domain has been named NEW3 but its actual function is not known. It is found on proteins which are bacterial galactosidases [1]. The domain is associated with the NPCBM family, Pfam:PF08305, a novel putative carbohydrate binding module found at the N-terminus of glycosyl hydrolases.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.62	0.72	-3.93	29	604	2012-10-03 16:25:20	2008-05-06 14:23:52	4	85	329	11	233	617	92	78.10	22	12.53	CHANGED	spsGcpsslphshsssu.sssspslplslss.PsGWs...stssssphs...slssGpslpsshpVpsPssAsuGs....Yslpspsphs	..............................sGps.hshp.lsl.p.N.ps..ss......s..h..p..s...h..sls.h......s......s...P.sG.......Ws.........s....s..s...s....p.hs......sl.s............s..............G..........p.s.........ts....sshslss..Psss...sGs......Y..lshpst..s............................	0	110	180	223
+10466	PF10634	Iron_transport		Fe2+ transport protein	FIGfams, Mistry J	anon	FIG005173 (Release 2.0)	Family	This is a bacterial family of periplasmic proteins that are thought to function in high-affinity Fe2+ transport.	20.50	20.50	20.50	21.20	20.10	19.70	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.86	0.71	-4.32	30	560	2009-01-15 18:05:59	2008-05-06 17:09:52	4	1	550	30	101	300	159	153.60	53	80.44	CHANGED	AtAtEhPIGc...Ptph..sGMEluAVYLQPl-MEPp.Gh.....hssscoDlHLEADIHAsc..sNsNGFucG.-.WlPYLslsYpLpchsssc.spcGshMP.MVAsDGPHYGsNl.KL.......tGsGpY+lpapIpPPup......ttFGRHsDKETGV.........us..WFcPaslpY.-FpasG	...............................................................htEhPIGc.......Ppph..ssMEIAAVYLQPI-MEPc..Gh.....thsAucuDlHLEADIHAsc..sN.sGFu-G-..WhPYLs.lsYcLpppDoG......p.....h......pcGohMP.MV.A.s.DGPHYGsNl.Kh........GsGpYcLsahIpsPpp......tuatRHlDcET.G.V...........Gt....Wac..P..hslcY.-FpYsG.................................	0	26	56	85
+10467	PF10635	DisA-linker		DisA bacterial checkpoint controller linker region 	Murzin A, Coggill P	anon	Murzin A	Domain	The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by family DisA_N, Pfam:PF02457; the next 146-289 residues is this domain that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), thus forming a spine like-linker between domains 1 and 3. The C-terminal residues of domain 3 are family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis [1].	25.00	25.00	26.20	74.70	23.60	24.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.81	0.71	-4.70	39	608	2009-01-15 18:05:59	2008-05-06 17:13:32	4	5	605	8	154	378	117	145.50	42	40.47	CHANGED	LcDsusILs+ANQAlpTLEKY+ssLDcslssLssLEhEDlVTltDVspslQRhEMVhRIspEIcpYllELGsEGRLlshQLcELlss.l-p-thLlI+DYs.....pcshshpplhcplpslssp-Ll-hsslu+lLGYssssshlDs.l	....Lc-susILo+ANQAltTLE+Y+shLc-shssLotLEhEDhVTlpDVssVlQRlEMVhRIssEIptYlhELGsEGRLlpLQLsELlss.l-s-ttLll+DYh..................ppstshppsLppLppLoss-LL-hstlu.+hlGYssssph.Dp.............	0	67	124	144
+10468	PF10636	hemP		Hemin uptake protein hemP	FIGfams, Mistry J	anon	FIG024330 (Release 2.0)	Family	This is a bacterial family of proteins that are involved in the uptake of the iron source hemin [1].	25.00	25.00	30.90	30.40	24.10	16.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.53	0.72	-4.36	56	837	2009-01-15 18:05:59	2008-05-06 17:34:36	4	1	806	3	146	406	26	38.00	57	57.52	CHANGED	stlsocsLhp.GspplhIpHsGphYpLRlT+sGKLILTK	.......RplsSpsLLG.scu+llI-HsGQcYh..LRpTpAGKLlLTK...	0	25	79	112
+10469	PF10637	Ofd1_CTDD		Oxoglutarate and iron-dependent oxygenase degradation C-term	Wood V, Coggill P	anon	Pfam-B_18095 (release 22.0)	Domain	Ofd1 is a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N in the presence of oxygen.  The domain is conserved from yeasts to humans. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts [1].	20.70	20.70	21.50	20.70	20.30	20.60	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.94	0.70	-5.26	39	253	2012-10-10 13:59:34	2008-05-07 10:58:38	4	9	224	4	187	298	18	273.60	28	46.78	CHANGED	s-lsaLhpYlsPpYLss-sh-clpcpFt-cSslpLccFLpschuspl+phlctp-pc...phPtpup-lpt..s...................WpsAtPPHKpRYhahcsps........t..pt..t...pEh.................................Lsslh.S.uF+KWLshlTul.pl..................................................sSpp..llsRRFR.G.DYTLAostc..........ttc.....stLEsoLsLT..Po..................................................sW-ss...............................................................EhGGYElYM...................ss-----...............................tDsAlY+u...................................................................s-pDDulLhopssuWNsLslVLRDpGlL+FVKYVStsAKGsRWDlospasVc..-p-.p-cpp	..............................................................................t.-hphLhcalsPsYLsschhpplpcpFp-p..SplpLppFLppchhpplpphlcpp-hp.....................................................WpsttPPpK++Yhhhptpp............................h.p.................................................h...h.hpLhpSpuFhphLu.hTuL.pl..................................................................................................................ssp.p...h.hRRa...+pG..cYTLssstp............................ttcstL-.hsLsls..ss..................................................uWps........................................................................................................-hGGaphYh....................spt.tt.......................................................t.th.pt..............................................................................................scs-Ds.Lhohsss.NpLslVhR.D.pusL+FVKYluppu.s....sp............................................................................	0	65	99	153
+10470	PF10638	Sfi1_C		Spindle body associated protein C-terminus  	Wood V, Coggill P	anon	Wood V	Domain	This C-terminal domain of spindle-body-associated protein Sfi1 has an important role to play in the bridge-splitting during bi-polar spindle assembly, and this separation event possibly requires interaction with integral components of the nuclear envelope, such as the Mps2-Bbp1 complex [1]. Centrally to this domain is a region carrying centrin-binding repeats with repeating units containing tryptophan, family Sfi1_central, Pfam:PF08457.	20.80	20.80	22.60	63.20	18.80	17.10	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.54	0.72	-3.62	5	21	2009-01-15 18:05:59	2008-05-07 13:35:04	4	2	21	0	13	21	0	108.00	46	11.30	CHANGED	+shslsc-LpTPhKoPs.ttusTIPGSERVK+a+MEslKs.RYSRARRA..IPSPIKSSsVLDSTlK++Ls.........ssstls-csTTststph.lccpsK+luSKV+cIcFs+IPp	.......hshpp-LcTPlR..oss..psusTIPGSERlKpaRMEAMKS.HYSRARRA..IPSPlKSSSlLDSTAKKpIs.........hcss.sslssssopshPhh...c+ps+NhsSKlc+IcFsRIPt..............................	0	1	6	12
+10471	PF10639	UPF0546		Uncharacterised protein family UPF0546	Coggill PC	anon	UPF0546	Family	This family of proteins has no known function.  Many members are annotated as potential transmembrane proteins.	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.52	0.71	-4.26	16	235	2012-10-02 19:55:49	2008-05-08 09:31:42	4	5	195	0	151	384	13	111.00	33	75.97	CHANGED	LLlVullWGsTNPhl++uStGhppspps.......hhh-h+a.........LhpphcYhlPhllNQoGSVlFahsLscs-LSluVPlsNSLsFlhTllsu.hlLtEchhst+ohlGhhLVlsGssLCs	........................................................................hlhVuhhW.G.hT.sP..hl.++uu....ts.hpthpp...........h...p..hhtchth...........................................Lhhs.pYhl.PhllN......sG.S.lh.a.a..h..h...Lup.s............-LSLuVPlsN..SLuF.lFTllsu.hhltccl.h.u.p.p.s.hhGhhLhlhGlslC...................	0	44	77	117
+10472	PF10640	Pox_ATPase-GT		mRNA capping enzyme N-terminal, ATPase and guanylyltransferase	Coggill P	anon	Karlin D	Domain	This domain is the N-terminus of the large subunit viral mRNA capping enzyme, and carries both the ATPase and the guanylyltransferase activities of the enzyme. The guanylyltransferase enzymatic region runs from residues 242 (leucine)-273(arginine) [1], the core of the acitve site being the lysine residue at 260 [2]. The ATPase activity is at the very N-terminal part of the domain [3].	25.00	25.00	324.10	324.10	20.70	20.00	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.90	0.70	-5.64	14	75	2009-09-10 16:44:40	2008-05-09 14:14:22	4	1	47	0	0	67	0	314.60	67	37.27	CHANGED	hspssssc-lpHEVELlalpPPLlTLoNlh..sluoppESYIhFolss.tccpsKlRs+lPhS+lHGLDlKNsQLV-slDsIlWE+KoLlpEpc..l.c.ptsllRaSTEE+alFlDY.....K+ahSuI+LELVNllps+lKsll.VDFKlKYFLGSGAQuK..SSLLasLNH...PKs+PssoLEFEIlsp.s....pplspstLhsELpslh+tlF.MusscslhL.s.sthcsPl+ThMLKKQ-l.sl-L-sLYlToKTDGVhshVplsppulaCaFoHLsYhI+Yshp+pl-splhL..aGEAlK..tsphhslalIKlhpPt.........lsDRlcEtcalp-pL	.l-.QsSTAYEINNELELVFIKPPLITLTNVV..NISTIQESFIRFTVTN..KEGVKIRTKIPLSKVHGLDVKNVQLVDAIDNIVWEKKSLVTEsR..L.H.KECLLRLSTEERHIFLDY.....KKYGSSIRLELVNLIQAKTKNFT.IDFKLKYFLGSGAQSK..SSLLHAINH...PKSRPNTSLEIEFTPR-s....EpVPYDELIKELTTLuRHIF.MASPENVIL.S.PPINsPIKTFMLPKQDIVGLDLENLYAVTKTDGIPlTIRVTScGlYCYFTHLGYIIRYPlKRhIDo.EVVl..FGEAVK...DKsWTVYLIKLIEPV.........IsDRLEEScYVESKL.	0	0	0	0
+10474	PF10642	Tom5		Mitochondrial import receptor subunit or translocase	Wood V, Coggill P	anon	Pfam-B_89651 (release 22.0)	Family	This protein family is very short and is only found in yeasts. Tom5 is one of three very small translocases of the mitochondrial outer membrane. Tom5 links mitochondrial preprotein receptors to the general import pore [1]. Although Tom5 has allegedly been identified in vertebrates this could not be confirmed.	20.20	20.20	21.40	21.40	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.20	0.72	-4.32	11	73	2009-01-15 18:05:59	2008-05-09 16:07:55	4	1	72	0	57	61	0	48.30	39	89.28	CHANGED	MFGs.stsQ.ScEEl+tpEcpAstTlppAshuAshLa..lSPhlhchl..pK..h	...MFGs.s..p.ScEEl+AtEtpAstTlppssssushLY......LSPhslchVp+..h.....	1	12	29	49
+10475	PF10643	Cytochrome-c551		Photosystem P840 reaction-centre cytochrome c-551	FIGFam, Mistry J, Coggill P	anon	FIG055090 (Release 2.0)	Family	A photosynthetic reaction-centre complex is found in certain green sulphur bacteria such as Chlorobium vibrioforme which are anaerobic photo-auto-trophic organisms. The primary electron donor is P840, a probable B-Chl a dimer, and the primary electron acceptor is a B-Chl monomer. Also on the donor side c-type cytochromes are known to function as electron donors to photo-oxidised P840. This family is thus the secondary endogenous donor of the photosynthetic reaction-centre complex and is a membrane-bound cytochrome containing a single haem group.	26.30	26.30	26.50	26.60	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.61	0.70	-5.06	7	19	2009-01-15 18:05:59	2008-05-09 16:46:09	4	4	15	2	16	20	1	172.00	39	84.60	CHANGED	MDNKSNGKLIALAlGGAVLMGALFFGVSFLTGYplPAENlSslLTPL+SFhGWFLLIFhASLIIhGLGKMSS+ISDKWFLSFPLoIhsIVAlMFs.L...W.+.........GRTTTlDGcYIRoVspLcAFL...................scPAsussVPsA.............PA.......................GhDFsAAKcLhss+CNKCHolsSVtDtL+.KY+KpGps-hlVhcMpuhPsSGIoccDsssIh.alsE...KY	...............................D.ppphpLhulAhhGAhhMGsLhahlShLTGa..PA.NhS.hLsPLpSFhGWhhLIhhuSlhIhshG+MSutISspWFlShPlshhhIVhlMFh.L...W.+.........G.RTTh.-Gp.IRoVtpLpta....................ppsshstphs.s..st................................s.shsuAcpLhst+CNc.CHTlcoVt-th+.+YcKpGpl-hlVp+MpshPsSsIoccDshpIh.YLpppa.........	0	1	7	13
+10476	PF10644	Misat_Tub_SegII	Misat_Myo_SegII;	Misato Segment II tubulin-like domain	Wood V, Coggill P	anon	Pfam-B_7826 (release 21.0)	Domain	The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins Pfam:PF00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils [1]. This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.64	0.71	-4.03	51	270	2012-10-03 12:11:42	2008-05-09 17:02:44	4	8	225	0	187	2002	14	111.20	33	21.93	CHANGED	+EIlTlQlGpauNalGoHFWNhQEuha..sYsspsp.......stl.spDVlaRp...Ghs..h.psphTaTPRlllhDLKGuhGoLpptut.LYp......................ptsp.tsssssWs.......s...phshpc.ps...htpspapps.L-p	.................+EllTlQlGph.uNal.usHaW.N.......h........Q.....-uhh.............shssppp..................s.l...sp.D..V.haRs.........Ghs......h.pGptTYTPRhllhDLK.G.u.h.G...o...Lpp...ss...LYp..........................tpt..sss.hhWp.............u...phshpp..p..hsps.Y..psLt.t..................................................................................	0	53	98	150
+10477	PF10645	Carb_bind		Carbohydrate binding	Wood V, Mistry J	anon	Pfam-B_63360 (release 22.0)	Domain	This is a carbohydrate binding domain which has been shown in Schizosaccharomyces pombe to be required for septum localisation [1].	25.00	25.00	26.80	39.00	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.09	0.72	-4.15	5	22	2009-01-15 18:05:59	2008-05-12 12:10:23	4	4	14	0	20	21	0	52.20	46	19.55	CHANGED	uoCGuApYDuupYVC.DsshLCPIlsGsPLpsCNGACYssShYuCoNGuLu.l	t.pCGsu.YDPupYlC....ssphLCPIssG.shphCsGACYsthhYsCsNssLs.....	0	8	15	19
+10478	PF10646	Germane	GerMN;	Sporulation and spore germination	Rigden D, Coggill P	anon	Rigden D	Domain	The GerMN domain is a region of approximately 100 residues that is found, duplicated, in the Bacillus GerM protein and is implicated in both sporulation and spore germination. The domain is found in a number of different bacterial species both alone and in association with other domains such as Amidase_3 Pfam:PF01520, Gmad1 and Gmad2.  It is predicted to have a novel alpha-beta fold.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.35	0.71	-10.70	0.71	-3.93	160	1597	2009-01-15 18:05:59	2008-05-12 17:01:59	4	13	985	0	421	1297	99	116.80	19	37.80	CHANGED	hslYa........hs...sssth..........Llspsphh...............shhptslppLl.pG.P.............hhsslPssspl...........h.slplp.....s.hshlshop.phhp....ssss.cph....h....ltsllhTLs.phs.t......lppVpl.hl-Gcshphht	..................................................................................h.plYa........hs.......pss.ph.............llspsptl.................sssps.hhptslptLl.pG....Ptst..............htssls..ss.spl............................h..shslp........ts.hspls.hsp..phhp.......hssp.tpph........h.ltpllh.TLs.phs.s.........lppVpl.hlsGp.h....h.......................................	0	178	338	387
+10479	PF10647	Gmad1		Lipoprotein LpqB beta-propeller domain	Coggill P	anon	Rigden D	Domain	The Gmad1 domain is found associated with the GerMN family, Pfam:PF10646, in bacterial spore formation. It is predicted to have a beta-propeller fold and to have a passive binding role rather than a catalytic function owing to the low number of conserved hydrophilic residues.	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.71	0.70	-4.99	26	420	2012-10-05 17:30:43	2008-05-12 17:22:56	4	16	404	0	114	623	108	247.70	24	43.11	CHANGED	sGul................sp....hsuspssslsGshu..pst.shsSsAlStsuppsA.............uVs.......sssssLhlGshGussspsh....sup.....slocPSashs.sslWsVss.usssscllh......sss......Gpss........................stV-ssshs..........slsslplSRDGsRsAhll....s..uplhluslp+sssG...thtlssPhclsss.tpsssuluWtssssllVhspsssssV.h...VslDGutsssh.susshssslhusuussst.....lhsssssulhp.....spssphWpplsshhss....PshP	......................................................................................................Gthht......hss.tphp.h.s.GshG......pss.s.susAlut..s..s..p.....hsA................................uVs.............sstps..Lh.s..s.s.h...G..u.p.s.hpsh...............sGt......sL.s.+.P..oa.......s......h.......s...ss.........lW..sss-..sssslplht.......................ss..............Gpht...............................................phsV-.h.suhst.............tlsslpl....S.DGsRsAhll.......s....sp..l.hl...uhlp+spsu.......phhhshsh.phu..s....hs...slssluWhss.s.p..Ls.Vh..s..ps..s.ss..sVth.......lsl.DGus.......sss....ut...hsss.hsulsusssp.............lhls...s..stsll............tpts.tWppl.thhss.....s........................................................................................................................................	0	37	82	109
+10480	PF10648	Gmad2		Immunoglobulin-like domain of bacterial spore germination	Coggill P	anon	Rigden D	Domain	This domain is found linked to the GerMN domain Pfam:PF10646 in some bacterial proteins. It is predicted to contain an immunoglobulin-like all-beta fold.	25.70	25.70	26.30	27.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.78	0.72	-3.81	20	66	2009-01-15 18:05:59	2008-05-13 09:15:26	4	10	62	0	37	66	15	87.70	28	26.99	CHANGED	hplplppPpssshlsu......slpVpGp..Ap.sFEuslshclp-usupll.tcthspAssussuhGpFpsslshsss..ss.pupltVhpssspsGs...h	.................IhlhsPt.sshVsu......shpVpGp....Ap...sFEuslsh+l...hDusGpll.scshsp..As.su..usshGsFpsplshps.t.st..puhl..plaphSscDGo.h..................	0	22	31	36
+10481	PF10649	DUF2478		Protein of unknown function (DUF2478)	FIGfam, Mistry J, Coggill P	anon	FIG046046 (Release 2.0) 	Family	This is a family of hypothetical bacterial proteins found in the vicinity of Molybdenum ABC transporter ATP-binding gene-products MobA MobB and MobC. However the function could not be confirmed. This family appears to belong to the P-loop superfamily by alignment to Pfam:PF03266. However, the characteristic P-loop sequence motif appears to have diverged beyond recognition in this family.	22.10	22.10	22.30	22.10	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.80	0.71	-4.90	57	205	2012-10-05 12:31:09	2008-05-13 16:49:41	4	3	152	0	78	206	9	157.00	37	79.33	CHANGED	lAAlshsss..sss.DtlLsshAtcLtup.GhRluGlV............Qtp.....tptssppsshp.lpsL.ssGppltIoQsLGsuupuCRLDsuuLspAsutlppAlsps..sD........LlllN+FGKpEupG+GhpshIspAlutslPVLsuVsppthcsWppFuuuhustLss-ppultsW	.....................lAAlhh.s.ps.sss.DsLLuphAtchppp.GlRluGhl........................Qpp.h...tssppspp.chc.lccl.soGt.p..hhI......S......Q...s....LGs..GS.....p..G..C..R..L.....DPuu....LA.c.A....u.u.sltsslpsu...sp........LLllN+FGKtEs-G+GhR.shItt.Ahut.sIPVLTsVsp.phl-u.W.c.cFuGshushLsssppulpsW....................................	0	13	38	55
+10482	PF10650	zf-C3H1		Putative zinc-finger domain	Wood V, Coggill P	anon	Wood V	Domain	This domain is conserved in fungi and might be a zinc-finger domain as it contains three conserved Cs and an H in the C-x8-C-x5-C-x3-H conformation typical of a zinc-finger.	20.90	20.90	20.90	20.90	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.40	0.72	-6.75	0.72	-4.45	14	159	2009-01-15 18:05:59	2008-05-14 12:01:54	4	9	125	0	107	155	0	22.10	48	1.64	CHANGED	hlC.aElsGthCNDcsCpaQHh+	...hC.a-LsG.sCNDc-CpaQHh...	0	31	47	76
+10483	PF10651	DUF2479		Domain of unknown function (DUF2479)	FIGfam, Mistry J, Coggill P	anon	FIG015005 (Release 2.0)	Domain	This domain is found in phage from a number of different bacteria.  It is purported to be a putative long tail fibre (Bacteriophage A118) protein, but this could not be confirmed.	21.10	21.10	21.20	21.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.66	0.71	-4.74	17	665	2009-01-15 18:05:59	2008-05-14 14:45:55	4	14	402	19	25	471	10	166.10	25	34.80	CHANGED	M....lpKhss.l-hphssphpshhstsIpFaspDp.sTAhlpFpls+cshPLslSptpscstlhLhhsss........hhhtslclhDsh..pGhlpYslPschlKp..sGpVpuplalp.p......sspslshtp.FoFpIccuLlsphss.ht.hYIcpF-clcchlpcphpcl..........cpslspspshhpp	...................................M......K..t.lphp.psph.sl.s....hsI.pF.h.ptDp.sou.sLphs.l.s.c....ss........t........s............lsLosp.tlps.clslhtcss.......t.hhsc...s...l.p...IlDsh..cGhlpYhlPschlcp..sGplcAplh.lpp.........ss...ps....l...s.s....pp.FoFslp..cuh.lsshsutph.sY.l...hsh.....pcl.....hchlp....cphpph.............cpshpphpp....p......................................................................	1	9	17	25
+10484	PF10652	DUF2480		Protein of unknown function (DUF2480)	FIGfam, Mistry J, Coggill P	anon	FIG020045 (Release 2.0) 	Family	All the members of this family are uncharacterised proteins, but the environment in which they are found on the bacterial genome suggests a function as a glucose-6-phosphate isomerase (EC 5.3.1.9).  This could not, however, be confirmed.	25.00	25.00	114.20	114.10	24.20	19.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.00	0.71	-4.68	18	81	2009-01-15 18:05:59	2008-05-14 18:13:37	4	1	75	0	40	88	197	167.00	47	98.13	CHANGED	M..t-...EIlNRVANSpLhTFDLEDaYPcGpRhhlDIppWLh-GllL+EK-FRptlKsHDWSpYpcpaVAlaCSTDAIlPuWAYMLlsspLpPaApKVVhGsL-sLEohlYp-llsplDlssacs+PVIIKGCScKPVPpsAYlhlhpKLQPVAKSlMYGEACSoVPLYK+	........-EI.lN+VA.pSsLlsFDLE-aYPpG.cR.h.hhDIcsaLapGhlL+EK-FRptlKpaDWopYpspaVAlhCSsDAIlPsWAYMLlsspLpPaA+cllhGsh-pLEptLapchlsplDhopapDc.VllKGCoccsVPpsAYlhhsp+L.pPlsKSlMaGEsCSoVPlaK+.........	0	17	36	40
+10485	PF10653	Phage-A118_gp45		Protein gp45 of Bacteriophage A118	FIGfam, Mistry J, Coggill P	anon	FIG0160151 (Release 2.0)	Family	This domain is found in bacteriophage and is thought to have a gp45 function within the phage tail-fibre system.	21.60	21.60	21.60	79.80	19.40	18.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.05	0.72	-4.11	2	34	2009-01-15 18:05:59	2008-05-16 10:25:53	4	1	26	0	1	17	0	60.50	87	100.00	CHANGED	MsERVFRKpT.FGsSEIahssRTKMIANPAFpQKIPL.ETGC-pMsDYIEELKLKGYEEVTR	MTERVFRKpT.FGsSEIahssRTKMIANPAFpQKIPL.ETGC-pMsDYIEELKLKGYEEVTR	0	1	1	1
+10486	PF10654	DUF2481	DUF2482; 	Protein of unknown function (DUF2481) 	FIGfam, Mistry J, Coggill P	anon	FIG020094 (Release 2.0)	Family	This is a hypothetical protein family homologous to Lmo2305 in Bacteriophage A118 systems.	25.10	25.10	25.90	83.80	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.61	0.71	-4.44	4	25	2009-01-15 18:05:59	2008-05-16 11:19:24	4	1	20	0	1	17	0	126.00	65	98.31	CHANGED	sVMElTENKARQREIISYlsNpsLshs-hKcLQKELNpLMNcNTEEKpKTaWsKThcRlVtNKpWp-ITltEFl-LRHAGLos.AIADaFplS+uslFNaT..pcN+pEYa+hFshs.YpKsKEhWsD	..sVMEhTcsKARQREIISYIsNNDlpLs-LhcLQKELNpLMNENT.EKQKTYWoKTFDRIV++KcWsEITIpEFs-LRNAGLTsYAIA-HFKVSKulVFNYT..QRNKKEYYplFDMsEYQKNKEhWND......	0	1	1	1
+10487	PF10655	DUF2482		Hypothetical protein of unknown function (DUF2482)	FIGfam, Mistry J, Coggill P	anon	FIG030041 (Release 2.0)	Family	All the members of this very small, very short family are derived from bacteriophages, of the SA bacteriophages 11, Mu50B, system, and from the Staphylococcal_phi-Mu50B-like_prophages subsystem. All members are hypothetical proteins.	25.00	25.00	45.10	45.00	23.50	23.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.21	0.72	-3.95	4	148	2009-01-15 18:05:59	2008-05-16 11:42:32	4	1	106	0	1	35	0	98.00	70	98.61	CHANGED	MTKNYKDMTQ-ElRDLLuEKsGELYELspEIccETEFDlLLFSolGVssGDhluSSpsALGsshsLAsLLcNpssacDlsNVIpMpKLQKhLGlDDsKED	..MTKNYKDMTQEElKDLLSEKoGELYELAKEIKtEocFDILLFSoIGVhDGDaluu.SsSVIGcsFDLAsLLDsscuY+DIlNVlQMpK.QKhLGIDDsKED......	0	0	0	1
+10488	PF10656	DUF2483		Hypothetical protein of unknown function (DUF2483)	FIGfam, Mistry J, Coggill P	anon	FIG032091 (Release 2.0)	Family	This is a family of proteins found in bacteriophage particularly of the SA bacteriophages 11, Mu50B, family, homologous to phi-ETA orf16.	25.00	25.00	41.10	41.00	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.42	0.72	-3.90	7	131	2009-09-11 01:17:25	2008-05-16 13:49:18	4	1	122	0	4	32	0	71.50	78	98.11	CHANGED	M.KpTV...TYlIKhKDt..sLYITN+PTstpsT.pYSss+pcAREFsGh--ssIDMstHpAIKKTVTETpEYEEVth	...M.KQTV...TYIIRHRDM..PIYITNKPTDNNSDISYSTNRNRAREFNGMEEASINMDYHKAIKKTVTETIEYEEVEH..........	0	1	1	4
+10489	PF10657	RC-P840_PscD		Photosystem P840 reaction centre protein PscD	FIGfam, Mistry J, Coggill P	anon	FIG031038 (Release 2.0)	Family	The photosynthetic reaction centres (RCs) of aerotolerant organisms contain a heterodimeric core, built up of two strongly homologous polypeptides each of which contributes five transmembrane peptide helices to hold a pseudo-symmetric double set of redox components. Two molecules of PscD are housed within a subunit. PscD may be involved in stabilising the PscB component since it is found to co-precipitate with FMO (Fenna-Mathews-Olson BChl a-protein) and PscB. It may also be involved in the interaction with ferredoxin [1].	23.40	23.40	23.60	117.30	22.40	23.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.77	0.71	-4.35	8	13	2009-01-15 18:05:59	2008-05-16 14:15:59	4	1	13	0	11	13	0	142.40	66	98.98	CHANGED	MQsQLSRP.TusNQVRsSs.................SGPWSGNAAHKAEKYFITSAKRD+pGpLQlpISPASGRRKLSPTcEMIsKlIuGEIELaVLTTQPDIuIDLsQKVLDNENRYVIDFDKRGVKWTMRDIPVFYcSL+ppLCVEIDRpoYTLDEFFK	...MQsQLSRP.TusNQVRtSs.................SGPW.SGNAsHKAEKYFITSAKRD+ps+LQlpIsPASGRRKLSPTpEMIsKlIsGEIELaVLTTQPDIAIsLppKVLDNENRYVIDFDKRGVKWTMRDIPVFYsohp+pLCVEIDR+sYTLsEFFK	0	1	2	8
+10490	PF10658	DUF2484		Protein of unknown function (DUF2484)	FIGfam, Mistry J, Coggill P	anon	FIG030013 (Release 2.0)	Family	A role of this family in UDP-N-acetylenolpyruvoylglucosamine reductase, as MurB, could not be confirmed.	25.00	25.00	25.80	52.30	23.30	19.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.78	0.72	-3.86	23	57	2009-01-15 18:05:59	2008-05-16 17:16:29	4	1	43	0	11	57	5	75.80	44	91.47	CHANGED	Ms....luLhLuslWslsAsllAhLPSRppHWptAal..LlAlGlPLLGaVsapsGPhhGlhsLsAGhSlLRWPVhYlh+hlR	......MshSLlLAslWslsAsllAhLPuR.pHWptAhl..LIusGlPLlGaVsappGPahGlhsLhAGhShLRWPlhYLh+hlR..	0	1	8	9
+10491	PF10659	Trypan_glycop_C		Trypanosome variant surface glycoprotein C-terminal domain	Bateman A	anon	Pfam-B_1351 (release 3.0)	Domain	The trypanosome parasite expresses these proteins to evade the immune response.	21.40	4.60	21.60	4.70	21.30	4.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.28	0.72	-11.30	0.72	-3.70	103	238	2009-01-15 18:05:59	2008-05-17 14:12:18	4	6	9	2	67	241	1	95.60	29	21.67	CHANGED	C.tt.tpspspCp.....p.ssCpas..ppppcsp..Cchppsp....tppps.tsstttt.........stppsp+C.ttcp.cscCtp.s...........CKW..-sppC..KDSShLlsK+hAL..huuAFlAL........LF	..............................................C..pthpppppCp...pttCpap..tptpptc....Cp.pppptppps.sssststs........spsssppCps+p..cscCcp.s.....................CpW...........-tppC......+-SShLlsKpFAL..huAAFsuL.L.............................	0	0	67	67
+10492	PF10660	MitoNEET_N		Iron-containing outer mitochondrial membrane protein N-terminus  	Coggill P	anon	Wiley S	Domain	MitoNEET_N is the N-terminal region of the MitoNEET and Miner-type proteins that carry a zf-CDGSH, Pfam:PF09360, redox-active 2Fe-2S cluster.  The whole protein regulates oxidative capacity. The domain is an anchor sequence that tethers the protein to the outer membrane.	21.30	21.30	21.30	26.70	20.60	17.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.95	0.72	-4.12	9	136	2009-01-15 18:05:59	2008-05-19 13:08:18	4	2	85	3	88	127	1	53.10	38	42.79	CHANGED	M..pslSpllps.hPthLttlPlPcohtshh+Lshp-WLsLlshsussAulGYlsY+sFhsKc+pp	..................hp..hs.hhtthPhPpohtsahp.LshpEWltLl.PhhuslAslGYLAh+sFhsKc+p...............	0	20	25	48
+10493	PF10661	EssA		WXG100 protein secretion system (Wss), protein EssA	FIGfam, Mistry J, Coggill P, Desvaux M	anon	FIG043089 (Release 2.0)	Family	The WXG100 protein secretion system (Wss) is responsible for the secretion of WXG100 proteins (Pfam:PF06013) such as ESAT-6 and CFP-10 in Mycobacterium tuberculosis or EsxA and EsxB in Staphylococcus aureus. In S. aureus, the Wss seems to be encoded by a locus of eight CDS, called ess (eSAT-6 secretion system). This locus encodes, amongst several other proteins, EssA, a protein predicted to possess one transmembrane domain. Due to its predicted membrane location and its absolute requirement for WXG100 protein secretion, it has been speculated that EssA could form a secretion apparatus in conjunction with the polytopic membrane protein EsaA, YukC (Pfam:PF10140) and YukAB, which is a membrane-bound ATPase containing Ftsk/SpoIIIE domains (Pfam:PF01580) called EssC in S. aureus and Snm1/Snm2 in Mycobacterium tuberculosis. Proteins homologous to EssA, YukC, EsaA and YukD seem absent from mycobacteria [1].	21.00	21.00	21.80	21.60	20.90	20.30	hmmbuild  --amino -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.95	0.71	-4.52	4	267	2009-01-15 18:05:59	2008-05-19 16:20:43	4	1	265	0	8	83	1	130.50	47	86.05	CHANGED	ItuuADSYLpcsGKhchKlDRlpcocpEKNc..cthcETELDKsuIpLFssEh-cclpcKppsEpc-h-clcsuLF.cphcss.sVK-TKcpLFSu-Y.ssu..schApo....EspTcsshS.sllhhhuGsllhlCsGlYslhR+lac	................tshh.slssp............................pcE...Ec+hss-Lsp.YDTTLFNKD.sKtVN-.s..htcpK.c-.pQpIKNchFQNQ.A.S+u..T.RL..s...ET.KKVLFSK...o.NlpKo...oESDKS..PYI..QNKQEKpIaP.Y.ILhSlGA.hLTLGhlI.........FsIa+t.....................................	2	2	4	7
+10494	PF10662	PduV-EutP		Ethanolamine utilisation - propanediol utilisation	FIGfam, Mistry J, Coggill P	anon	FIG047026 (Release 2.0)	Domain	Members of this family function in ethanolamine and propanediol degradation pathways, however the exact roles of these proteins is poorly understood [1-3].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.59	0.71	-4.70	20	1157	2012-10-05 12:31:09	2008-05-19 16:22:45	4	8	759	0	91	4581	2185	127.50	43	87.54	CHANGED	MK+lhLlGtoGsGKTTLsQsLpG.....c-L.+Y+KTQulcapsss.IDTPGEYlEsRpaYsALhsous-ADlIuLlhsAsp.hssFsPGFuuhFsKPVIGIlTKlDLu.sppplphscphLppAGApcI.FclSulsspGl-ELhsYLpp	..........................................................................MKRlh.h..lGsstsGKTT.Lh.pu.L.pG....................p...h........hh.........+......K............T........Q...........A..........l...............E.............a.............s.............s.............p...........s.........I...............D........T.......P...G..........E........Y.........h........p........p..................p........h.......Y....p.....A........L........l.......s......o........h........p.........-.....s.........D......h.....l....h..h.V.h...s........A........s........s........................t.......o.....h.......h...s.......s.....G.......h......h.........s.......h.......h........s........+..........h.....I............u......l......l...o...KsD.h...s...............s.....t...c......l.....u....h....s.....+.....p...h.....L........p.......c........s........G......h........c........c........I........F.........l..suhsspuV.ppLhcaLt.s..........................................................................................................	0	46	65	79
+10496	PF10664	NdhM	DUF2485; NADHqo1-M; NADHdh-M;	Cyanobacterial and plastid NDH-1 subunit M	FIGfam, Mistry J, Coggill P	anon	FIG006356 (Release 2.0)	Family	The proton-pumping NADH:ubiquinone oxidoreductase catalyses the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides.  Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 sub-complexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1]. The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms [2]. The three subunits of NDH-1, NdhM, NdhN and NdhO are essential for effecting cyclic electron flow around photosystem I, by supplying extra-ATP for photosynthesis in both plastids and cyanobacteria [3, 4].	19.80	19.80	20.90	90.80	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.31	0.72	-4.14	21	90	2009-09-11 07:47:26	2008-05-23 11:37:31	4	1	84	0	43	86	121	108.50	58	75.56	CHANGED	LKsTTRHVRIFTAcVc.ss-Llsss..spLTLDlDPDNEFlWs-sulpKV.p+FcELV-utuGp-Lo-YNLRRIGSDLEtaIRpLLQsGEluYN.suRVLNYSMGLPRssp	.LKSTTRHlRIasAclc.ss-Llsss...spLTLDlDPDNEFlWs--ulpKVYp+FcELV-shsG...t-Lo-YsLR+IGSDLEHaIRpLLQsGElSYNhsuRVlNYSMGLP+lt.t....................	0	7	27	38
+10497	PF10665	Minor_capsid_1	Phage_Gp9;	Minor capsid protein	FIGfam, Mistry J, Coggill P	anon	FIG016324 (Release 2.0)	Family	This is a putative tail-knob or minor capsid protein from bacteriophages.	25.00	25.00	25.60	25.30	23.50	21.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.40	0.71	-4.24	5	90	2009-12-03 14:34:41	2008-05-23 13:52:04	4	1	89	0	7	71	0	111.50	28	97.94	CHANGED	Mlht.PlPhchLIHoloYcEY..hGEDca...GpssYuKPllIE+VRVsPscchssuosucolhaNAVlFlDulNS.sPhhpFpc...pSKIsFcGK-asIpKVIPsYss.ScslHHaELEVl	.............................shchLlcslphc..th...t.s.c.sca...spss.YscslpIcpVRhDh.......s.......pshsss......ssu..cptths..ul.....IFl.sshS..ssh.s-hpp.....tu+lh.....as.G.c.-Y.sIscl.ssYts.s.splapaElEV..........	0	2	6	7
+10498	PF10666	Phage_Gp14		Phage protein Gp14	FIGfam, Mistry J, Coggill P	anon	(Release 2.0)	Family	This phage protein family is of unknown function but is expressed from within a cluster of tail- and base plate-producing genes [1].	21.30	21.30	21.70	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.80	0.71	-4.32	2	24	2009-12-01 14:53:38	2008-05-23 14:29:37	4	1	22	0	1	16	3	127.00	72	98.20	CHANGED	MsQNNVINIQLEESYQEFQLGTELFRVGLGDcMRRKWIEADEKYKKKLEKLNKYNIDNTDEMSSE-YFsLEEDVKEALTEAYAlLLDDEcAFsKCYtQCKDILKMYQVYsQVAE.IVGSVEKQQNEIQKKYKAKMTKKAK	....MsQNNVINIQLEESYQEFQLGTELF+VGLGDEMRRKWIEADEKYKKKLEKLNKYNIDNTDEMSSE-YFsLEEDVKEALTEAYAlLLDDEcAFsKCYtQ.CKDILKMYQVYsQVAE.IVGSVEKQQNEIQKKYpAKMTKKAK...........................	0	1	1	1
+10499	PF10667	DUF2486		Protein of unknown function (DUF2486)	FIGfam, Mistry J, Coggill P	anon	FIG008383 (Release 2.0)	Family	This family is made up of members from various Burkholderia spp. The function is unknown.	21.50	21.50	22.30	21.50	21.00	21.30	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.90	0.70	-3.83	10	64	2009-01-15 18:05:59	2008-05-23 16:06:39	4	2	63	0	15	70	3	213.10	43	94.62	CHANGED	MopspssS...IPsLTDVLVPG+......Ps.ARuouuDss.........s+DsAAhPlLss..s.s.t.susut.....ccspsssc.lsscPlPoPclssVthPuc...................sDAPAcPu..uut+VluccAsAhpAPhPssLAsDsstsssuuAs...........hsAu-sA...PcussPuAsssussphutA............sspsAAshTs.DAppIAERLRsRlTsYLTG-GR-sIEARCRDALH-HouWLVGQITREVALALETEVhcWVR-AVcEEIARRsuG	..................................MspspssS...IPsLTDVLVPGp......Ps.ARssuusss............................pAu.P..............sssu...............pp.....sttpscss.sscPsssst..sssst.hPss...................pDAshtPu..st.cssA.tt.uhthPhsssLAs-.....s.s.shsAh.............h.AscsA...Pch...ssPAAhssssPtlsps....................................................Asu.hhss.h-AppIAERL+uRhTpYLTGEGRulIEARCRDALH-HuuWLVGQIsREVALALETEVhsWVp-AVsttLARRpss..........	0	1	2	7
+10500	PF10668	Phage_terminase		Phage terminase small subunit	FIGfams, Mistry J, Coggill P	anon	FIG022212 (Release 2.0)	Domain	This family of small highly conserved proteins come from a subset of Firmicute species. Its putative function is as a phage terminase small subunit.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.94	0.72	-4.19	6	212	2012-10-04 14:01:12	2008-05-23 17:12:29	4	8	173	0	19	242	9	60.70	37	24.56	CHANGED	MARpRsPcRDcAhchahESuGsh.LhDIAscLslssSQIRKWKupDKWs-.......p........hNuslT.......ppK	....................MsRt..RsP.p.....RDpAhcla...hc...ssGphpL+-I..AscLs......Vo.s.....upIR.....+WKopD.K...Wsp..............p.......hpussp...............................	0	5	13	15
+10501	PF10669	Phage_Gp23		Protein gp23 (Bacteriophage A118)	FIGfam, Mistry J, Coggill P	anon	FIG018382 (Release 2.0)	Family	This is the highly conserved family of the major tail subunit protein.	22.60	22.60	23.70	26.80	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.54	0.71	-4.00	3	16	2009-01-15 18:05:59	2008-05-23 17:22:57	4	2	15	0	2	7	0	120.90	88	55.90	CHANGED	MYEGLTKVFDYALAKEMFFAALFVALFIILLIITKRIWDDSKIVRVEMKEERDKMETEREKRDKESKEERDKFISTMNEQQRLMDKQNDMMGQQQQSIDSLSKSVGKLAHKVDLLEHKITK	.......MYDGLTKVFDYALAKEMFFAALFVALFIILLIITKRIWDDSKIVRIEMKE.EREKVEEEREKRNKESKEERDKFISTMNEQQRL...MDRQNDMMKQQQQSIDSLSKSVGKLAHKVDLLEHKITK...........................	0	1	1	2
+10502	PF10670	DUF4198	NikM;	Domain of unknown function (DUF4198)	Coggill P, Bateman A	anon	Pfam-B_42996 (release 22.0)	Family	This family was previously missannotated in Pfam as NikM.	34.00	34.00	34.00	34.00	33.80	33.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.44	0.70	-4.34	108	1021	2009-09-14 15:50:14	2008-05-29 08:59:34	4	7	729	0	303	893	241	211.50	19	81.58	CHANGED	ApAHthWlhPssshl.ssst.sh.htlthspshsssh...........................shph.......hsP............cGp.sshhp.......shtts.ptt.h..............ptssaplsh....thptsshashhhpst.hhpppt.....................s....sphhhphsKshl.......stsssspshppsh..GhslEllPls+P.ss....lhsGpshphpll.hcG+Phss.scVplhhtstchpsp..................shtlpTDssGhhohshspuGhahhsAhhpsst	..................................................................................................................AtAHthal.ss......p.....h..pttt..........htlha.s.c..shptt.h..tt....................................................shph...hps................sGp....tsh.t......................phtphph.........................ppssatlsh..........thp..s.uhas..h.hhps.h..h.hphpp...........................................t...sphhhphsKshl........p..t...s..s...p..t..h...p..psh....GhslEllPlsc.......P...s......lhsGps.....hphpll.hcG+Pls..s..splplphtsh.h.p.t....................................................shphpTD.s.pGhhshshspsGha.hhts.hpt..h...........................	0	105	215	264
+10503	PF10671	TcpQ		Toxin co-regulated pilus biosynthesis protein Q	FIGfam, Mistry J, Coggill P	anon	FIG032035 (Release 2.0)	Family	The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonisation in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localisation of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.	21.50	21.50	21.60	21.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.74	0.72	-4.10	60	393	2009-01-15 18:05:59	2008-05-29 13:17:40	4	6	315	2	76	322	9	85.90	27	34.59	CHANGED	stsaphp.sspsLcpsLpcWApps........GWplh...Wp.sst..Da.lsushsasG..sFpp.........Alpplhps..hpssshslpsshat..usplltlspht.............p	............s..tWph..sssTL+psLpcWApps...........sWplh...Ws.ssh........-apl-uslsapG..sFcs.........Alpplhph..h..p...sspt.s....lhsph.p......tppllhVss....pp.................................	0	19	40	58
+10504	PF10672	Methyltrans_SAM		S-adenosylmethionine-dependent methyltransferase	Coggill P	anon	Meireles D	Family	Members of this family are S-adenosylmethionine-dependent methyltransferases from gamma-proteobacterial species. The diversity in the roles of methylation is matched by the almost bewildering number of methyltransferase enzymes that catalyse the methylation reaction. Although several classes of methyltransferase enzymes are known, the great majority of methylation reactions are catalysed by the S-adenosylmethionine-dependent methyltransferases.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.82	0.70	-5.56	3	4405	2012-10-10 17:06:42	2008-05-29 15:15:01	4	12	3015	23	953	3434	475	251.00	27	55.36	CHANGED	RRLFHGRGRpWPGLEQITCDWLQGQLLVNLFKEVDDAFLuuLKcGLsALsuuslWAoKQGRolVLQHRYADGAPSEVLlGELs-oPVVVEsGLKYQLDIGRNQNFGLFLDMRhGRcWVQENAKuKNVLNLFAYTCGFSVAAIAGGAcQVVNVDMARGSLSKGRDNHRLNGHDlspVSFLGHDIFKSWGKIKKuGPYDLVIIDPPSFQKGSFALTKDYKKILRRLPELLsEGGpVlACVNSPAVoPDFLIEoMAEEAPsLcFlERLDNPPEFsDVDs-AuLKVLLFR	.........................................................................................................h.htt.............................................................................................................................................................................................................................t....t....h..h...h..G....c...h..s..p..h..h.....l....p....E...p..G....h....+...h.h.Vs...l.p..c..s..h.cTGlFLD.pR....t.s....R......p........h.......l.......t........p.....h............u.........c.......u........K...............c.......VLNh.F.oYTGu...FoV..t..A.u...h..G........G..A...p.p.ss.oVDh.SppuLch.u.c.....c.N.h.p.LN........u.......l.......s.....h......p......p...t..............c...............h....l...p...s.......D.....s.......F.................c...h....h.........p....p......h...........c....c........p.........t...............p...a.DlIllDPP...........s..F......s......c......s......p......h....s.....l.....p...+...s...Y....t...c...l........t...t....s....h....pl....L...p..s....s.G.h...l.h......h..s......ss......s.........h......................................................................................................................................tttp.hh.t..............................................................................................................	0	328	573	786
+10505	PF10673	DUF2487		Protein of unknown function (DUF2487)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	26.50	26.30	22.60	21.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.76	0.71	-4.39	15	163	2009-01-15 18:05:59	2008-05-30 11:09:48	4	1	162	0	32	124	0	137.50	48	89.88	CHANGED	l-pYLpu+-YIDTAlIPLlslsh..spchKphsppGEFstlLupElERQhKGRlhLhPuFTYlsssppptth..cLpcWpsclpppuFcHVhalTuDpsWK...ttpshpsp.llW.lPulPLEp.....................hscshK+cllc-plpQllshLhp+W	......lEpaEQAR-YVDTulIPLlSISs..ucchKpsVEQGEFlcLLShELERpaKGRVlLLPAFTYLs-.sQ+scps..RLp-WoscLpppGFKHIsYVTSD..hu...WK..pthp-lpGc.LhW.hPolsLEp.....................hsDptKREll+s+l+plhshL.pKW....................................	0	11	23	26
+10506	PF10674	Ycf54	DUF2488;	Protein of unknown function (DUF2488)	Mistry J	anon	PRODOM	Family	This protein is conserved in the green lineage and located in the chloroplast.	25.00	25.00	32.80	32.20	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-10.13	0.72	-3.86	24	115	2009-01-15 18:05:59	2008-05-30 11:33:57	4	2	101	7	50	116	96	90.40	50	67.26	CHANGED	sTYaalhASc+FLhpE...EPLEEVL+ERpRaYtEpsKcIDFWLVppPAF..LpuPEhupl+schPpPuAAllSTsspFIsaLKLRLEaVhpGpFEAP	.......pTYaallASp+FLl-E...EPh-ElL+ERhRpYtEpsKElDFWLVhpPuF..L.-ssphsclpt+l......sp......PusAlVSTstpFI.T.alKLRL-aVlpGpFEA.......	0	14	36	46
+10507	PF10675	DUF2489		Protein of unknown function (DUF2489)	Mistry J	anon	PRODOM	Domain	This is a bacterial family of uncharacterised proteins.	19.80	19.80	20.70	20.80	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.40	0.71	-4.47	51	301	2009-01-15 18:05:59	2008-06-02 09:38:11	4	1	297	0	73	216	44	130.00	39	84.44	CHANGED	IluLusYAshLLhpL+cQpt.p........pppptstppRptplh-SIclIApA.hhpcpC-lSEGslRltsLh-hlshs.p...tspYsuhhplYchlcchPpt-sR+pLsKpcRh+hDhpR.phEschcctIhp-sppL	.............IluLuuYAsaLLhpL++Qpt.p........pptphAhppRpspIh-SlpllspA.hl.psQC-LSEusIRlhsLh-hlttptp........tppYPAhhcLYclV+cMPpt-s.RppLsKpERM+.-Lp.RppAEucLpcsIhtElptL.............	1	15	35	59
+10508	PF10676	gerPA		Spore germination protein gerPA/gerPF	Mistry J	anon	PRODOM	Family	This is a bacterial family of proteins that are required for the formation of functionally normal spores.  Proteins in this family may be involved in establishing normal coat structure and/or permeability which could control the access of germinants to their receptor.	20.80	20.80	20.80	20.80	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.37	0.72	-4.13	32	769	2009-01-15 18:05:59	2008-06-02 11:22:48	4	1	146	0	83	320	2	70.30	37	91.63	CHANGED	MPuhl...uslpIpslsusGslslGDshtISPpussKohuGuGuhNsGDhl....h.NhhshTsshDsDlsDQs.htNs	......MPuhV...sslhIpN..ssGshslGDsasloPhssoKuasGuGusNsG.hls...shstlSsTsshDsDlsDQs.hhs.s....................	0	17	45	53
+10509	PF10677	DUF2490		Protein of unknown function (DUF2490)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins. They appear to belong to the outer membrane beta barrel superfamily.	29.80	29.80	29.80	33.60	29.70	29.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.78	0.71	-11.19	0.71	-5.03	62	262	2012-10-03 17:14:37	2008-06-02 12:42:47	4	1	180	0	128	283	185	196.50	20	83.77	CHANGED	chssWhphthptpl...s......pchthph-hphRhtcs.............hs.chpphhlRsulsYpl.ssphplsh...GYsahhsps.tt.............thsEpRhapphhhphs..htphplspRhRhEpRahpt..........................ssphphRhR.plphphPlspptht......hhhhsElFhsl........stpsaspsRhhs.Glsaplspp..hplphGYhtp.......ttsspspchlth	.............................................................thWhpht.hptcls.........pchphth-hphR...htss.............hs.phpphhl+sulsYpl.ssphplth.......GY...sahhsp.hts.....................ptEpRhatphp.hphp..hs...ph.....pls..pRhRhEpRahtt..........................................ssch.phRhR.tlphshsl.spphht.......hhh.sElFhsh........t.hsppthcpsRhhs.Glsaplspp...hpl-lGYhtQh.pt...ttss...p....h.........................	0	66	112	122
+10510	PF10678	DUF2492		Protein of unknown function (DUF2492)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins.	19.70	19.70	20.90	20.90	18.50	16.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.50	0.72	-3.90	22	608	2009-01-15 18:05:59	2008-06-02 12:58:25	4	2	593	0	55	219	6	75.70	69	97.41	CHANGED	hsSlHGHpVhplMltpspsho+tpLpphltpcFGppARFHTCSApshsA-pLlpFLhpKGKhl.scpGhsssts+lCp	.....MDSIHGHEVLNMMIESGEQY.THuSLEAAIK.....A...RFGEpARF.HTCSAEsMTAuELVAFLAAKGKFI.s.s.E.-.GFSTcpSKICR...............	0	8	20	36
+10511	PF10679	DUF2491		Protein of unknown function (DUF2491)	Mistry J	anon	PRODOM	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	33.50	33.40	20.80	18.60	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.16	0.70	-11.18	0.70	-5.33	16	485	2009-01-15 18:05:59	2008-06-02 13:05:10	4	2	472	0	38	197	8	212.60	70	97.47	CHANGED	M.......FpchFG.+csps..ssPps.........P..hGLtlGtulplDsLthc..LLsschtltls.sssphItAhGcVcLspuspLhRaYsDD-sal.QVlssGs.stsclcDlpLahaa-otsluucu-apchlts..plutspYch-Gh.papRhWsssts..pscsVshsEclhptsss...spclpQhsMLYtRplst.spcEhLLlssEEc.....pps-hslshulGlsLpssDlpl	.........................h....FQRLFG..KcsKP..AlsRG................P........LGLHLNuGFTLDTLAFR..LLE-.pLLlALP..GE-..a.....TVAAVS+IDLG..GGSQIFRYYTS........G..DEFL.QINTTGGpDlDDIDDIKLFVYEESaGIocEsHWR-AIs.s......ps.....hGAM.TLN..W.....Q......E.K...RWQRFFNSEEP.GNIEPVYMLEKVENQscA...KW-VHNFTMGYQRQVT-....D....saEYLLLNGEESFN-.hGEPEWlFSRALGVDIPLTSLcI.........	0	9	17	24
+10512	PF10680	RRN9		RNA polymerase I specific transcription initiation factor	Wood V, Coggill P	anon	Pfam-B_44021 (release 22.0)	Domain	Initiation of transcription of ribosomal DNA (rDNA) in yeast involves an interaction of upstream activation factor (UAF) with the upstream element of the promoter, to form a stable UAF-template complex. UAF, together with the TATA-binding transcription initiation factor protein TBP, then recruits an essential core factor to the promoter, to form a stable preinitiation complex [1]. This Rrn9 domain, which seems to be constrained to fungi, is the two highly conserved regions of proteins which form one of the subunits of UAF and appears to be the region responsible for the interaction with TBP. The family includes the S.pombe Arc1 protein, Swiss:Q10204, which is found to be essential for the accumulation of condensin at kinetochores [2].	25.00	25.00	31.70	29.40	23.30	22.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-10.06	0.72	-4.24	22	106	2009-01-15 18:05:59	2008-06-04 12:54:52	4	4	105	0	80	106	0	72.80	33	14.00	CHANGED	L-sLc...tcDLulHLYsuahL+ph...A...ttp.hp.s.........................................sthhPp+pWouWPh.sspVP.sspphh....D	......L-sLc...ppDLulHLYsAahLK+t................ttp..p.s.................................................sthhPp+pWTAWPhs.sscVPtsspph.p............................	0	11	36	65
+10513	PF10681	Rot1		Chaperone for protein-folding within the ER, fungal	Wood V, Coggill P	anon	Pfam-B_27706 (release 22.0)	Family	This conserved fungal family is an essential molecular chaperone in the endoplasmic reticulum. Molecular chaperones transiently interact with unfolded proteins to inhibit their self-aggregation and to support their folding and/or assembly. Rot1 is a general chaperone with some substrate specificity, its substrates being the structurally unrelated Kre5 Kre6 Big1 Atg22, which are type I, type II, and polytopic membrane proteins. The dependencies of each for Rot1 do not share similarities. However, their folding does require BiP, and one of these proteins was simultaneously associated with both Rot1 and BiP. In addition, Rot1 may cooperate with BiP/Kar2 in the folding of Kre6 [1].	23.20	23.20	23.20	36.10	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.53	0.70	-4.99	28	127	2009-01-15 18:05:59	2008-06-04 13:13:12	4	3	108	0	89	128	0	202.10	44	86.02	CHANGED	LhGTWSoKSspVhTGPGFYDPls-hLlEPsLsGISYSFTcDGaaEEAhYRssuNPpsPsCPpuhlhaQHGoYplp.sNGoLhLsPhtVDGRQLlSDPCsss.....hus...YoRYsQsEpFppapV.lDs.Ya.Ghh+LpLapF.DGoPhpPhYLsY+PPhMLPTpTL..NPostst........................tpcthR...........phhcpshps.tpp......shhpp...thh..sthaWhulhhhuhGuhshh	..........LhGTWooKSppVhTGP...G.........FYDPlc-hhlEPshsGISYSF....TcDG.aaEEAhYpshuNPpsPsCspuhhhaQHGoYplp.sNGoLhLsP..htsDGRQLlSDPCssp.........tup........YoRYsQs.EhF.........ppap.Vhl......Ds....Y.......H...uhhpLpLap.a..DGo.PhpPhYLsY+PP.MLPTpoLNPsspst........................ttp..t.hR.................phhppp.h.t...hpp......shhtp....t..p.shhWahuhhhhuhGuhhhh...................................	0	27	48	76
+10514	PF10682	UL40		Glycoprotein of human cytomegalovirus HHV-5	Mistry J, Coggill P	anon	PRODOM_PD113623	Family	This is glycoprotein UL40 from human cytomegalovirus or herpesvirus 5. The signal sequence of the UL40 polypeptide contains an HLA-E ligand identical with HLA-Cw*0304. The first 37 residues of UL40, including this ligand, are predicted to encode a signal peptide.  The virus thus prevents the lysis by NK (natural killer) cells of the cell it has invaded [1-2].	25.00	25.00	38.00	27.60	20.60	19.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.75	0.70	-4.83	2	171	2009-01-15 18:05:59	2008-06-04 14:21:54	4	1	6	3	0	168	0	212.50	94	96.35	CHANGED	hRhtFhhssMAP+TLll...llhhtl.u.hs..ApTssTTsGAhhupsP+.....C.hVFpGWVYAhYHpGsMsLMTlDV.CCR.pssNo........tcspLLI-VGNpTRpt....oCpsH..u.Q.tDC.sphVHVpGlspStFhLopLpSCCLNp.SpLSE+VAYHL+hRPAsFGLETWAMYTlGlLuLGSFSSFYsQlh+sL....psaHYAhKt	......................................TRIGFTCAVMAPRTLILTlGLLCMRIRSLLCSPAETTVTTAGshSAHGPh.....CPLVFQGWAYAVYHQGDMALMTLDVYCCRQTSSNTVVAFSHHPADNTLLIEVGNNTRRHVDGISCQDHFRA.QHQDCPAQTVHVRGVNESAFGLTHLQSCCLNEHSQLSERVAYHLKLRPA.TFGLETWAMYTVGILALGSFSSFYSQIARSLGVLPNDHHYALKK........	0	0	0	0
+10515	PF10683	DBD_Tnp_Hermes	Hermes_DBD;	Hermes transposase DNA-binding domain  	Bateman A	anon	PDB:2bw3	Domain	This domain confers specific DNA-binding on Hermes transposase [1].	20.50	20.50	20.70	23.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.29	0.72	-4.51	4	22	2009-01-15 18:05:59	2008-06-04 16:21:41	4	5	13	2	13	19	0	61.90	36	13.87	CHANGED	pspEL+hVStpDKcEAIEKCTQWVVcDCpPFSAVoGuGFhchVKFFlKIGA.YGEpVDV-DLLPsPsT	............................pKpchhc+ssp....aslpDhRPFshVpGpGFhcLsphhlplGApYGppVsl-slLPpP.T.....	0	1	7	11
+10516	PF10684	BDM		Putative biofilm-dependent modulation protein	Mistry J, Coggill P	anon	PRODOM_PD064586	Family	This is a family of tightly conserved proteins from Enterobacteriaceae which are annotated as being biofilm-dependent modulation protein homologues.	27.40	27.40	27.40	90.60	27.00	27.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.12	0.72	-3.76	2	398	2009-09-11 08:44:46	2008-06-04 16:56:56	4	1	396	0	9	28	0	71.60	95	100.00	CHANGED	MCFINLRSVADTINTQTRRITMFTYYQAENSTAEPALVNAIEQGLRAEHGVVTEDDILMELTKWVEASDNDILSDIYQQTINYVVSGQHPTL	.....................MFTYYQAENSTAEPALVNAIEQGLRAEHGVVTEDDILMELTKWVEASDNDILSDIYQQTINYVVSGQHPTL..	0	2	2	5
+10517	PF10685	KGG		Stress-induced bacterial acidophilic repeat motif	Mistry J, Coggill P	anon	PRODOM_PD027049	Family	This repeat is found in proteins which are expressed under conditions of stress in bacteria. The repeat contains a highly conserved, characteristic sequence motif,KGG, that is also recognised by plants and lower eukaryotes and repeated in their LEA (late embryogenesis abundant) family of proteins, thereby rendering those proteins bacteriostatic. An example of such an LEA family is LEA_5, Pfam:PF00477. Further downstream from this motif is a Walker A, nucleotide binding, motif GXXXXGK(S,T), that in YciG of E coli, eg Swiss:Q8X7B4, is QSGGNKSGKS [URL]. YciG is expressed as part of a three-gene operon, yciGFE, and this operon is induced by stress and is regulated by RpoS, which controls the general stress-response in E coli. YciG was shown to be important for stationary-phase resistance to thermal stress and in particular to acid stress.	20.40	20.40	20.50	20.40	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.29	0.72	-6.39	0.72	-3.93	45	2185	2012-10-01 20:07:30	2008-06-05 11:36:42	4	12	679	0	402	1036	15	21.90	59	59.07	CHANGED	sFAs.Dt-+tpEhupKGGcuSsu	......NFtp.D.c+A...SEAG+KGGQpSsG.....	0	82	192	315
+10518	PF10686	DUF2493		Protein of unknown function (DUF2493)	Mistry J, Coggill P	anon	PRODOM_PD031789	Family	Members of this family are all Proteobacteria. The function is not known.	24.50	24.50	24.60	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.43	0.72	-4.43	34	308	2009-01-15 18:05:59	2008-06-05 14:06:06	4	3	207	0	113	326	118	70.40	36	28.33	CHANGED	PpGs+lAFoGGtDap...Daph........IWssLDcl+A+h.....PDMl..LlHGGss+GAEpIAApWAcsR..sVsQlsF+PDWp+HG	.............................Gs+lhloGGt-.as...Dpch....................last.L.D.p....l+s+t.....P-.hl...LlHG.....Gu..+GA-tIAupWA...cpR.....t..Vsp..l..s...FpsDWpc+............	0	22	74	95
+10520	PF10688	Imp-YgjV		Bacterial inner membrane protein	Mistry J, Coggill P	anon	PRODOM	Family	This is a family of inner membrane proteins. Many of the members are YgjV protein.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.74	0.71	-4.81	34	708	2009-09-11 16:42:10	2008-06-05 17:27:52	4	3	624	0	127	358	26	145.00	42	89.78	CHANGED	thhhuQhlGhlAhslslhuF.pKpcc+lhhhlhstsllhulHFhLLGuhsAAshhhluulRhhhulhspS.........phlhhhFlslsllh...shhshpshhsllslhGolluThAhFphcGlp.hRhhhlluossWlhpNlllGShGGsLhEshhlssNhlslYR...happptps	....................ahlAQulGsl.AFhlGIosFas+--+Rh+hpLslausllulHFhLLGshsAuhoslLsulRoh.l.o....l+Tc.S.........hhVMs.lFIlL...ohsh..............Gl.sph....p.c.l.ELLPllGTlluTaALFpscGls.hRs.V.MhhuTsCWVIHNhahGSIGGohlEuoFllhNulsIlRaaRhpppu.................	0	23	55	90
+10521	PF10689	DUF2496		Protein of unknown function (DUF2496)	Mistry J, Coggill P	anon	PRODOM_PD581819	Family	This family consists of proteins from Gammaproteobacteria spp. Many members are annotated as being like the E coli protein YbaM.	25.00	25.00	40.00	39.90	18.50	15.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.73	0.72	-4.37	25	670	2009-01-15 18:05:59	2008-06-06 09:53:35	4	1	667	0	66	195	1	43.90	73	79.54	CHANGED	sL-sAP-ElKLAVDLIhLLEsN-I-PpsALuAL-IVppDappKL	..SLENAPD-VKLAVDLIVLLEENpIPAcTVLRAL-IVKRDYEpKL.	0	4	17	43
+10522	PF10690	Myticin-prepro		Myticin pre-proprotein from the mussel	Mistry J, Coggill P	anon	PRODOM_PD189357	Family	Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis, the Mediterranean mussel. Some isoforms show antibacterial activity against gram-positive bacteria, while others are additionally active against the fungus Fusarium oxysporum and a gram-negative bacterium, Escherichia coli D31.  Myticin-prepro is the precursor peptide. The mature molecule, named myticin, consists of 40 residues, with four intramolecular disulfide bridges and a cysteine array in the primary structure different from that of previously characterised cysteine-rich antimicrobial peptides. The first 20 amino acids are a putative signal peptide, and the antimicrobial peptide sequence is a 36-residue C-terminal extension. Such a structure suggests that myticins are synthesised as prepro-proteins that are then processed by various proteolytic events before storage in the haemocytes as the active peptide. Myticin precursors are expressed mainly in the haemocytes. The family Mytilin has been merged into this family.	28.50	28.50	28.60	39.60	25.70	28.40	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.82	0.72	-3.96	5	179	2009-01-15 18:05:59	2008-06-06 09:56:07	4	1	5	1	0	179	0	98.50	78	99.26	CHANGED	MKATILLAVlVAVlVAVpEAcuhuCTSYaCuKFCGoAuCoaYlChlLHsGKhCtCLHCSRs+.PhthotcA+shNEt...hDhoPpMN-MENLDpGMDM...........l	MKATILLAVVVAVIVGVQEAQSlsCTSYYCSKFCGSAGCSLYGCYhLHPGKICYCLHCpRAESPLALSGSARNVN-pNpEMDNSPlMNEhENLDQEMDMF..	0	0	0	0
+10523	PF10691	DUF2497		Protein of unknown function (DUF2497) 	Mistry J, Coggill P	anon	PRODOM_PD475087	Family	Members of this family belong to the Alphaproteobacteria. The function of the family is not known.	20.90	20.90	21.80	29.30	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.48	0.72	-4.01	43	281	2009-01-15 18:05:59	2008-06-06 10:13:57	4	1	277	0	96	223	45	73.60	40	34.00	CHANGED	pcsLlStssspssssshpsLupslp............ssp..tpTlE-lVc-hLRPMLp-WLDpNLPslVEclVcpEIcRls+p	.........................................................................................................................sllSptotpplusuFpsLscslp.............ss..tppolE-lstEhLRPhLpsWLDcNLPsLVE+lV+cEI-Rls+.s...	0	29	54	67
+10524	PF10692	DUF2498		Protein of unknown function (DUF2498)	Mistry J, Coggill P	anon	PRODOM_PD060534	Family	Members of this family are Gammaproteobacteria. Many are annotated as like E coli protein YciN. The function is not known.	25.00	25.00	26.00	26.00	17.90	16.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.58	0.72	-4.37	12	633	2009-01-15 18:05:59	2008-06-06 10:33:02	4	1	631	2	51	152	1	81.20	75	98.44	CHANGED	pspppPIscpsLLh.ANplI+-HEDYlpGMcATsVEQKssVLVF+GEaFLDEpGLPTsKTTAVFNMFKaLAHhLStKYpLhc	....p.KETQPIDRETLLtEANKIIREHEDTLAGIcATGVTQRNGVLVFoGDYFLDEQGLPTsKSTAVFNMFKHLAHVLSEKYHLVD.................	0	4	14	32
+10525	PF10693	DUF2499		Protein of unknown function (DUF2499)	Mistry J, Coggill P	anon	PRODOM_PD077121	Family	Members of this family are found in plants, lower eukaryotes, and bacteria and the chloroplast where it is annotated as Ycf49 or Ycf49-like.  The function is not known though several members are annotated as putative membrane proteins.	22.10	22.10	24.50	23.70	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.36	0.72	-3.94	39	145	2009-01-15 18:05:59	2008-06-06 11:16:05	4	4	121	0	85	138	93	85.40	48	53.36	CHANGED	sLSlsTWhIHluSllEWhlAIhllhcau..phptppshphLulAMlPsLlSAhsAhTWHhFDNs.sLthLVsLQAhhTllGN..hsLshAAapl	..........ALSlPTWhIHlSSVlEWlhAhhLlapYu..phsspptW+tLuhuMlPtLsuAhCACTWHhFsNs..uLphLVsLQAshTllGN..hTLshAAah..........	0	27	54	76
+10526	PF10694	DUF2500		Protein of unknown function (DUF2500)	Mistry J, Coggill P	anon	PRODOM_PD076478	Family	The members of this family are largely confined to the Gammaproteobacteria. The function is not known.	22.00	22.00	22.00	22.00	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.27	0.72	-4.06	28	788	2009-09-11 12:25:21	2008-06-06 11:50:33	4	3	759	21	73	338	5	111.30	46	90.70	CHANGED	PlhhhllhhlllshhsFhah......phhpcatpspsAPhhslpspllsK+ppshscspspp............psp....cYalpFchpsGs...................+hEFpV.usc.YptLs.GDpGpLTaQGs+FlpFsh	.............................................PLFFIllluLI.lVAAo.F+Fh......QQRRE+AsN-hAPlppc.VsVosKRE+slsDRRSRQpEV.ssA......uooh....RYEsoF+Pp.sGG...................EpsFRL..suppYHALssGD+GTLoY+GTRFluF..s.........................	0	17	33	49
+10528	PF10696	DUF2501		Protein of unknown function (DUF2501)	Mistry J, Coggill P	anon	PRODOM_PD096667	Family	Members of this family are all Proteobacteria. Several are annotated as being YjjA or YjjA-like, but this protein is uncharacterised.	19.80	19.80	19.80	23.00	19.30	19.60	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.54	0.72	-4.00	19	613	2009-01-15 18:05:59	2008-06-06 13:05:51	4	1	595	0	55	226	8	79.70	64	49.43	CHANGED	KNNhLu.u.ssAssVKspLhuKLGhsstp.tspDssYtsGlpGlLssusGpplsLs..Gs.sLppplKpKACDhVLpQGpu..Lh	.............KQKLAS...s..TssENIKNQlLpKLGLsopE.QccDTNYL-GlQGLLKTKDGQQLNLsN.....IGoTPLAEKVKTKACDLVLKQGLN.h.h....	1	4	20	38
+10529	PF10697	DUF2502		Protein of unknown function (DUF2502)	Mistry J, Coggill P	anon	PRODOM_PD029719	Family	Members of this family are all Gammaproteobacteria. The function is not known.	20.60	20.60	29.10	23.20	18.00	18.20	hmmbuild  --amino -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.13	0.72	-3.88	13	798	2009-01-15 18:05:59	2008-06-06 13:44:39	4	2	515	0	54	211	7	83.10	63	77.09	CHANGED	pIsL.l.......PuVpLQIGDRDpRGpYWDGhcWRDcsWW+pH............YpWcGsRWpc+ssttcpta.+cp...................chDc+p........s+Gss++H	............EITL.LPSIKLQIGDRDchGNYWDGGHWRD+caW+p+....................YEWRtNRWa+H-s..s..h.+.+.s.a.cK+pt...............thccRDDHR...G+GtG+tH..............................................................	0	3	13	30
+10530	PF10698	DUF2505		Protein of unknown function (DUF2505)	Mistry J, Coggill P	anon	PRODOM_PD099734	Family	Members of this family are all Actinobacteria. The function is not known.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.53	0.71	-4.73	34	427	2012-10-02 19:24:03	2008-06-06 16:13:37	4	2	348	0	112	314	13	158.00	27	92.63	CHANGED	h-hsspas.ssl-pVapshsccsYaps+hpphus...tsplsphsssusG.....hplshpp..sl.sc.pLPuhlpphhssclplpcpEpW.ssht..supspuphpsslsGsPsslsGshtLps......susuophplsuslcVcVPLlGGKlEphluspltchlssEpchsppWl	...................................................................p.sspas.sss-pVhthhsctsa...Wpshh.p.phus....splp..s.hss...s...s..cu.......lplshtp....hlssp.....L..Puhl..pp.hls.u...s.Lplc..pspoW..ss..hs..sus...tpuo...ls...ss..lt.....GsPsphsGptslps................susG.oclphsuslpVpl......P.....llG...uKlEphhusplsphhshEpchsspWl...............................	0	35	81	103
+10531	PF10699	HAP2-GCS1		Male gamete fusion factor	Bateman A, Coggill P	anon	Billker O	Domain	The gene encoding Arabidopsis HAP2 is allelic with GCS1 (Generative cell-specific protein 1). HAP2 is expressed only in the haploid sperm and is required for efficient guidance of the pollen tube to the ovules. In Arabidopsis the protein is a predicted membrane protein with an N-terminal secretion signal, a single transmembrane domain and a C-terminal histidine-rich domain [1]. HAP2-GCS1 is found from plants to lower eukaryotes and is necessary for the fusion of the gametes in fertilisation. It is involved in a novel mechanism for gamete fusion where a first species-specific protein binds male and female gamete membranes together after which a second, broadly conserved protein, either directly or indirectly, causes fusion of the two membranes together. The broadly conserved protein is represented by this HAP2-GCS1 domain, conserved from plants to lower eukaryotes [2]. In Plasmodium berghei the protein is expressed only in male gametocytes and gametes, having a male-specific function during the interaction with female gametes, and being indispensable for parasite fertilisation. The gene in plants and eukaryotes might well have originated from acquisition of plastids from red algae [3].	19.70	19.70	20.20	26.60	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.41	0.72	-4.00	22	100	2009-01-15 18:05:59	2008-06-07 15:35:39	4	1	68	0	69	107	1	48.30	38	6.85	CHANGED	hllspshhshsGt...pCsKIGVShpsapsp.s...sh.Cst..GoCLpsQLtcaap	..........hlLs+shhslsGh...-CsKIGVSapuFpsQ.s...sh.Cst.huoCLpsQLtcah......	1	30	46	62
+10534	PF10702	DUF2507		Protein of unknown function (DUF2507)	Mistry J, Coggill P	anon	PRODOM_PD089657	Family	This family is conserved in Firmicutes. The function is not known.	30.00	30.00	30.80	30.10	29.60	29.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.66	0.71	-4.48	22	327	2009-01-15 18:05:59	2008-06-09 15:33:57	4	2	325	2	57	203	0	123.60	42	79.59	CHANGED	ssFuhpLlR-hlLPslLGp-psslLYWAGKcLAR+aPlpohE-l.tFFppAuaGsLplhKpK+pphhFpLoGshlspRlpp..ppssFpLEAGFlAEplppppthssEuh..thp++..pppVhlpVph	...............shFuhpLlR-hLLP-lLGsDtssILYWAGKcLARKaPLpohE-lhpFFcpAuaGsLollccK+pchpapLpGsllspRhcp..p.ccssFpLEAGFIAEplQpQpshssEuh.tphc++..p.c.pVphhVp......................	0	16	34	44
+10535	PF10703	MoaF		Molybdenum cofactor biosynthesis protein F	Mistry J, Coggill P	anon	PRODOM_PD122919	Family	MoaF protein is essential for the production of the monoamine-inducible 30kDa protein in Klebsiella [1]. It is necessary for reconstituting organoautotrophic growth in Ralstonia eutropha [2]. It is conserved in Proteobacteria and some lower eukaryotes. The operon regulating the Moa genes is responsible for molybdenum cofactor biosynthesis.	22.40	22.40	22.70	22.60	19.20	22.30	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.64	0.70	-5.32	12	151	2009-01-15 18:05:59	2008-06-09 16:14:14	4	2	115	0	36	122	6	252.70	41	92.97	CHANGED	sssstaIsVGALA-GFA.csplLsssssLuG+shsLphssGtshtpthssp........psLpWpthttt.................GpusYRAoplRsulYaVDalc.tpspt.SVSLVlDhpptphouVhGpLPsc..Atsp.sshsRshpsh.LTuVcspFhaGslss.htsus..huPTc-LIGhRshYpYSPoEsYEHIYLNssaYsWQCLpGsE+GLADsDRC+haKlA-pLYLFVWREKllPTLGVllIDLp...thRoDGKIFGYpsuDFushsNFslGAaupVLNpTpH	....................................................s.pssalpVGALA-GF..-sphLsssssLsG+slslt.....hssG..thh.ph.t.F..ss........psLpWcttpss.................GpssY+AoplRsslaFVDal.........c.sptss.olSLVlDhsptshouVhGplPsc..st.chsuhsRVtpsh.lTuVpstFhaGslss.h.tsus...u.Tc-LIGpRshYpYS..PoEsYEHIYLNssaYsWpCLsGsE+GLAD.V.......DRC+haKlA-sLYLFsWREKl.l.PTLGVllIDLp...ttRocGKlhGYpsuDhusluNFPlGAauplLNpTha.......................	0	3	10	23
+10536	PF10704	DUF2508		Protein of unknown function (DUF2508)	Mistry J, Coggill P	anon	PRODOM_PD057080	Family	This family is conserved in Firmicutes. Several members are annotated as being the protein YaaL. The function is not known.	20.40	20.40	20.50	20.90	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.30	0.72	-3.80	23	434	2009-01-15 18:05:59	2008-06-09 16:57:29	4	1	431	0	88	236	2	72.40	30	89.37	CHANGED	M......Fh++K....scl++....-hD-cLlphlpcs+ccappp+pl.ppoh-..ss.p-lhhptKlscAKYhFLh+EA+pRplphp	.............................................hhp+p.....cl+c.........p.hD.....p.c..Llphlccs+pchppt.+phhcps..h-....s..pps...lhph+lAcAKYhaLh+EA+pRtl+h.p......	0	36	65	75
+10537	PF10705	Ycf15		Chloroplast protein precursor Ycf15 putative	Mistry J, Coggill P	anon	PRODOM_PD014917	Family	In some species of plants the ycf15 gene is probably not a protein-coding gene because the protein in these species has premature stop codons. Most of the members of the family are hypothetical or uncharacterised [1].	25.00	25.00	25.60	39.40	21.10	18.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.25	0.72	-3.93	3	64	2009-01-15 18:05:59	2008-06-09 17:56:30	4	1	62	0	4	51	0	72.20	68	98.05	CHANGED	ETLVSSIFWTLAPWNNMLLLKHGRIEILDQNTMYGWYELPKQEFLNSEQPEPITHYIKKFPLMKcIGPpcpp+..htphSchlllotssoNHahN	.....................M..LLL..KHGRIEILDQNTMY..GWYELPKQEFLNSEQP..IhTT.KKa.lhhclsP.cppK..h...................t............	0	1	3	3
+10538	PF10706	Aminoglyc_resit		Aminoglycoside-2''-adenylyltransferase	Mistry J, Coggill P	anon	PRODOM_PD012767	Family	This family is conserved in Bacteria. It confers resistance to kanamycin, gentamicin, and tobramycin [1]. The protein is also produced by plasmids in various bacterial species and confers resistance to essentially all clinically available aminoglycosides except streptomycin, and it eliminates the synergism between aminoglycosides and cell-wall active agents [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.02	0.71	-4.65	3	186	2012-10-02 22:47:23	2008-06-09 17:57:47	4	1	128	4	26	138	5	140.20	38	79.89	CHANGED	MNcLHIsLIHpIFAAADclNLPLWIGGGWAIDARLGRITREHDDIDLTFPGDR+AEFEsLlcthGGpITEQTDYGFLAplQGlLLDCEPAaasD-AYEIE-sPPGSCPhssEGVIuG+PVRCNSWEAILWDYFYYtDEVPpu-WPsKHlaSasLAC-SLG-ssVcsLRcQF+oR	............................llshh-ctslshWlsGGWulDAhLG+.TRcHcDIDlsFsuc+ps.cl..sllc.h.G....h..+.l......c...h..s...hh..ltc.t...th..lDhcPh.hss-.u...htts.st.u.u...p...........t.....p....s.hts+.l.C.s............................................................................................................................................................	0	7	19	24
+10539	PF10707	YrbL-PhoP_reg		PhoP regulatory network protein YrbL	Mistry J, Coggill P	anon	PRODOM_PD110862	Family	This is a family of proteins that are activated by PhoP. PhoP protein controls the expression of a large number of genes that mediate adaptation to low Mg2+ environments and/or virulence in several bacterial species. YbrL is proposed to be acting in a loop activity with PhoP and PrmA analogous to the multicomponent loop in Salmonella where the PhoP-dependent PmrD protein activates the regulatory protein PmrA, and the activated PmrA then represses transcription from the PmrD promoter which harbours binding sites for both the PhoP and PmrA proteins. Expression of YrbL is induced in low Mg2+ in a PhoP-dependent fashion and repressed by Fe3+ in a PmrA-dependent manner [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-10.95	0.71	-4.98	22	504	2012-10-02 22:05:25	2008-06-10 11:39:02	4	2	480	0	35	279	172	183.00	67	87.86	CHANGED	lpLpppp.lupGspRhsYtHPtcssphlKVhpspt...................tsth+phtpElptYhplph.......+pth.hshls+haGhlpTshGhGhlh-hltDhsGshu.TLpphh...cpsthss.thtptLcphhphlh-scIlsp.-lpspNIVhtcpspup.....phhllDGhGstph...lPltshuphhs++plp+phc+hhpcht	.............................................................I+LSEQoPLGTGRHRKCYAH...PED...A...p...RC..IKIVY+Ru...........................-.G.G.DKE.IRRE.LKYY.AHLu........RRLcDWSuIPRYHG..TVETDCGT..GYVYDlIs....DF..D.G....K.PS.ITLT.EFAt....QCRY.E..E.D...lA.....p....LRQ...LL....K....pL...KRYL....pDN+IVTM.S.LKPQN..ILC+RISESE....VlPVVCD.N...IGESTL....IPLATWS.KWCChRKpERlW+RFIAQP.A................................................	0	11	18	27
+10540	PF10708	DUF2510		Protein of unknown function (DUF2510)	Mistry J, Coggill P	anon	PRODOM_PD056443	Family	This is family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed.	20.90	20.90	20.90	20.90	20.30	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.26	0.72	-4.49	31	349	2009-01-15 18:05:59	2008-06-10 13:08:27	4	19	198	0	127	284	30	37.80	43	13.84	CHANGED	sGWYPDPus....sp........phRaWDGppWTsph...pPh...Pussstss	..sGWYPDPsG....ss........thRaWDGspWTcps.............pPs.....st......t.......................................	1	48	96	123
+10541	PF10709	DUF2511		Protein of unknown function (DUF2511)	Mistry J, Coggill P	anon	PRODOM_PD064657	Family	This family is conserved in bacteria. The function is not known.	20.40	20.40	21.10	20.80	19.70	17.00	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.07	0.72	-3.64	14	641	2009-01-15 18:05:59	2008-06-10 13:21:12	4	2	562	0	53	212	2	86.40	68	76.30	CHANGED	slo+hcaGc.cWsFopEEVtLpC+sGsAL.ashNsuT.hpYPLN-lAppphct.Gp..upsIssIhlDDPs....pPG...................pKhS.LsPal-cA.pLC	.........TVSRFEVGKDKWAFNREEVMLTC..R....P......G...........N......A....L...YV..IN..PSTLVQYPLNDIApppVAo.GKTcAQPIuVIQIDDPs.....sPG.......................EKMS.LAPFIERApKLC..........................	0	7	16	31
+10542	PF10710	DUF2512		Protein of unknown function (DUF2512)	Mistry J, Coggill P	anon	PRODOM_PD032002	Family	Proteins in this family are predicted to be integral membrane proteins, and many of them are annotated as being YndM protein. They are all found in Firmicutes. The true function is not known.	23.70	23.70	23.90	25.00	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.93	0.71	-4.71	20	314	2009-01-15 18:05:59	2008-06-10 13:55:09	4	1	198	0	59	209	0	127.60	34	92.27	CHANGED	M+..HltALslKalhshslLhllLshhassoFscllhlollLolloYhlGDLalLPR......huNhsAoluDFGLualllWlhuhhhhs..sshsluhuollSAllluluEhFFHtYhhcplls.....p.tp.....phpapTEhu-E	.....................Mp.HhhsLllKhhhhhhllhlh...Lsl.hhs..ho.hspllhholhlohsuYhlGDhhILs+........hGNhsAohuDhsLualslWlhs.hhhs..sshpIuhuu.l.l.uA.l.llul.uEhaFHtahpppshp.....p.pt.t.....t.tathEhu-E..............	0	21	44	49
+10543	PF10711	DUF2513		Hypothetical protein (DUF2513)	Mistry J, Coggill P	anon	PRODOM_PD457411	Family	This family is found in bacteria. The function is not known.	29.40	29.40	29.40	31.40	29.00	29.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.39	0.72	-3.94	27	250	2009-01-15 18:05:59	2008-06-10 14:04:32	4	2	231	0	43	168	3	102.10	31	83.09	CHANGED	KhDh-llRclLLplEst.h...............tt.thstasp-..pl.YHlthL..p-AGllpuphpth............st..........hltpLTasGH-FLDslRcsslWpcsK.phtppsu...uhol	....................................KhshDhlRclLLclEsptphspsl...................pshth.spash-......slhYplthL..p-Ashlssp.htht................st.hh.h........hlpclTasGH-FLDsIR-spsWpcsK.phtsKsssho................	0	14	25	36
+10544	PF10712	NAD-GH		NAD-specific glutamate dehydrogenase	Mistry J, Coggill P	anon	PRODOM_PD017095	Family	The members of this are annotated as being NAD-specific glutamate dehydrogenase encoded in antisense gene pair with DnaK-J [1].	19.10	19.10	27.00	26.90	18.80	18.50	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.41	0.70	-6.24	21	144	2009-01-15 18:05:59	2008-06-10 16:57:01	4	3	117	0	30	146	1412	408.70	35	78.00	CHANGED	hsLptshptscsthDthhshshcLVAhlhpcLL.........GtVcpsluLVhuhcpLssLLVhhGVthGlLcHhlDlhlspsstuL.DtDLLhLsGuLVLGtcVcDAVGVDVEGchDLRHuARstRsshpVELs-cLVVtpHhsLsLEcsDtHutLVVhsGtEcLsLLGRDpuVAlDQsG-Hssp+hDAcRQRuHVEQQHVLcV.....ALQssuLDsuAcucsFVRVcshVRLLA.EElhHhhhDLtHsGhsADpcclVDlsttpAuVLpptLsRL-psL-plhcpuFpLGAuphcscV..LcstsltpDctpVDhGLhttRphDLtLhspFLpsLQsphVlsQVDullhLELsspVVD-spVEVFTAcEtVAVGshHFEpA....lsDhpDGcVEusAAcVlDRDthshh..LVcslGpRupGRLVDDspchcsuDhAGVLGsLTLuVVEVuRpGDDpltchhApluhGuFLHLhQccstcLtRplhLA....hphDPsVAlsulsDh.tpphhVLhphtVscusADQALctcpGVhRVtcsLsLuRLscpshsllscscDRRtGutAFsVhDchplsAl.HDucAuVGsscVDTssFsH	.........................................hp..hph.pthhs....hh.hphlu..h.....hhphhh..........tthpphhtLlhthtthhthhVhhulhhslhpHhhshhhhpsttsl.cuDllhhsuhhlhttplpDsVulDlEuphDLRpsu+pthss.plEhspphVlttph.shsLpch-t.ttLlVhtttEtLthhutDttVhhDphtccss.........tthsspt...pttpVpQp.lhtl.....shppssLpttspspshltVpshsthhs.cch.p.hhphhHsuhsspppphVsht.hpsslhpt.htthptshcplhtphhphtstph.hph..hts.t...tts.tplchGhhtttphshthhsthhp.sLptphlh..hplpshhhhchhtp.hDps.lplhssp.tlshut.phcth....hschpptplEtssspV.spc.hhh....h....lpsluptstuthVDDs.phpssshsulhGsL...sLtlV.cVst.tDstht.hhsplhhuthLchhpc.ttsLhtt.hLs......hphc.tlshh..tph.h..h.lhh.hhlh.hssspAhsttpushtVtctLshstlss.pshshht.ssctRtushshtlhpphthhsl..+st.stVutsplsss.ht.................................................	0	6	13	28
+10545	PF10713	DUF2509		Protein of unknown function (DUF2509) 	Mistry J, Coggill P	anon	PRODOM_PD077226	Family	This family is conserved in Proteobacteria. The function is not known but many of the members are annotated as protein YgdB.	25.00	25.00	26.00	25.80	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.98	0.71	-4.40	10	534	2009-09-10 15:07:53	2008-06-10 17:00:33	4	1	521	0	38	192	1	120.60	58	89.88	CHANGED	hLLlLG.LLLpGlppQLDuhhthsusEpptL+AastApSALsWGpuQsWutpst..........WpCpphsp.sh+uCLRhhSsuphlllcGput......slpLaQ.......pGssssssllhssHGW.DFCP.K-suhCp.hs	...................hLLlLGSLLLQGhsQQpcSaAuRVohESpuLRRQAlVQSALtWG.+.hpsWpspss....................hQCpp.Yu.....u.....osARVCLRlLu-sEslLlAGh-G.......VoLWR.........TGcV.I-GsI.VFSP+GWSDFCPLKEtALCQlP......	0	2	9	21
+10546	PF10714	LEA_6		Late embryogenesis abundant protein 18	Coggill P	anon	Covarrubias A	Family	This is a family of late embryogenesis-abundant proteins There is high accumulation of this protein in dry seeds, and in the roots of full-grown plants in response to dehydration and ABA (abscisic acid application) treatments [1]. This LEA protein disappears after germination. It accumulates in growing regions of well irrigated hypocotyls and meristems suggesting a role in seedling growth resumption on rehydration [2]. As a group the LEA proteins are highly hydrophilic, contain a high percentage of glycine residues, lack Cys and Trp residues and do not coagulate upon exposure to high temperature, and for these reasons are considered to be members of a group of proteins called hydrophilins [3]. Expression of the protein is negatively regulated during etiolating growth, particularly in roots, in contrast to its expression patterns during normal growth [4].	20.50	20.50	21.30	51.70	20.10	19.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.71	0.72	-4.17	6	28	2009-01-15 18:05:59	2008-06-10 17:33:36	4	2	14	0	17	26	0	80.70	48	71.36	CHANGED	SEcc..psp.-sLPhEsSPYscYcDLEDYKppGYGTpGHQEPKsG+GuGuTDAPT.SGu.hpucutsou....TDAtNp+usP	.........p.....ppscpptLPh-sSPYlpYcc...LEDYKh+uYGscGH.pPK.sG+GGGu.TDAPTlSGssh..........ucutsus.........sDAhNpps..................................	0	3	9	13
+10547	PF10715	REGB_T4		Endoribonuclease RegB T4-bacteriophage encoded	Mistry J, Coggill P	anon	PRODOM_PD091708	Family	The RegB endoribonuclease encoded by bacteriophage T4 is a unique sequence-specific nuclease that cleaves in the middle of GGAG or, in a few cases, GGAU tetranucleotides, preferentially those found in the Shine-Dalgarno regions of early phage mRNAs. Phage RB49 in addition to gpRegB utilises Escherichia coli endoribonuclease E for the degradation of its transcripts for gene regB. The deduced primary structure of RegB proteins of 32 phages studied is almost identical to that of T4, while the sequences of RegB encoded by phages RB69, TuIa and RB49 show substantial divergence from their T4 counterpart.	27.40	27.40	27.60	28.30	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.62	0.71	-4.10	14	136	2012-10-03 00:09:25	2008-06-11 13:56:22	4	1	74	1	0	99	0	142.10	24	90.69	CHANGED	Mp..........c.hphaphpatph.sphtchpcs.........tthsp.Ft...........lhap.p.hsp.h.+phctcashthhpplhspl...ph.t.huh...........cthphpsthh........ElpcGshhlulsssp.s.sh...tulththtlhsptph.tphshhhl	.....................p.t..h.hpp....c.hp.at.patph.sphtctscp........tslu.tFt...........lhappphhsc..sl...+..phccpashthFpclpspl..hph.....phluh...st....c....hlcshcapstph........Elp.....c....Gslhhu.h.osspss.ph...psuhphthsllpptph.tptphh................	0	0	0	0
+10548	PF10716	NdhL		NADH dehydrogenase transmembrane subunit	Mistry J, Coggill P	anon	PRODOM_PD026898	Family	The NdhL family is a component of the NDH-1L complex that is one of the proton-pumping NADH:ubiquinone oxidoreductases that catalyse the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. NDH-1L is essential for photoheterotrophic cell growth. NdhL appears to contain two transmembrane helices and it is necessary for the functioning of though not the correct assembly of the NDH-1 complex in Synechocystis 6803. The conservation between cyanobacteria and green plants suggests that chloroplast NDH-1 complexes contain related subunits [1].	25.00	25.00	53.50	53.50	22.20	21.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.02	0.72	-4.21	24	91	2009-09-10 15:53:21	2008-06-11 14:19:09	4	1	85	0	38	89	84	79.60	44	78.07	CHANGED	M..................................hhs.l..............psllVlhsYsuLuuhYLlVlPlhLahWhNpRWashuphERhhhYhLVFLFFPGhlLhAPFLNhR.psps.	.....................h..........h...............phhhlhlhYhsLushYLLVlPhhlahahppRWYhtuphERhhhYhLVFhFFPGllLhuPFLNFR.ps+p..	0	6	24	35
+10549	PF10717	ODV-E18		Occlusion-derived virus envelope protein ODV-E18	Mistry J, Coggill P	anon	PRODOM_PD579825	Family	This family of occlusion-derived viral envelope proteins are detected in viral-induced intranuclear microvesicles and are not detected in the plasma membrane, cytoplasmic membranes, or the nuclear envelope. The ODV-E18 protein is encoded by baculovirus late genes with transcription initiating from a TAAG motif. It exists as a dimer in the ODV envelope and contains a hydrophobic domain which is putatively acting as a target or retention signal for intranuclear microvesicles [1].	23.10	23.10	23.10	62.90	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.20	0.72	-4.54	18	56	2009-01-15 18:05:59	2008-06-11 16:54:42	4	1	53	0	0	50	2	83.90	47	99.70	CHANGED	MDshRss.......ssssth...phsslNPNhLMTILIsLVIIILLIhLFQ.SSsussSu....ssssptu..ahNPLNATMRsN.....PhV.NTsQRphL	....M-.hRss.......sssss..stplstlsPNhhMTILlsLVIIILLIlLFQSSSsussSu........s..s..........sssphuFhNPLNATMRsN.....PFV..NTsQRph..........	0	0	0	0
+10550	PF10718	Ycf34		Hypothetical chloroplast protein Ycf34	Mistry J, Coggill P	anon	PRODOM_PD019546	Family	This family is of proteins annotated as hypothetical chloroplast protein YCF34.  The function is not known.	25.00	25.00	44.20	44.10	16.40	15.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.81	0.72	-3.59	23	81	2009-01-15 18:05:59	2008-06-11 17:13:16	4	1	79	0	31	81	84	75.60	54	91.41	CHANGED	MCICVsCpaVDRCpTYHsVEpQHt.sHLopsPDFcPppPpIHVslh..s..ssthtlEWDVhuCpSFhp-.G+WsRLRP	.MCICVNCcaVDRC.TYHAVEpQHpp..s...HLo-...sPcF-Pp..p..PsIp.VNI+..........s.p....sstlchEWDVluCpSFhpEhGKWu+LRP.......................	0	8	22	30
+10551	PF10719	ComFB		Late competence development protein ComFB	Mistry J, Coggill P	anon	PRODOM_PD066657	Family	This family is conserved in bacteria. Some members, with three conserved cysteines, are annotated as late competence development protein ComFB.	25.00	25.00	28.70	28.60	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.71	0.72	-4.24	60	450	2009-01-15 18:05:59	2008-06-11 17:24:40	4	1	402	0	154	351	11	83.20	28	65.09	CHANGED	l+NahEclVhctlpp......tphpp..t.tspcslsDlsslALNpLPP+Ylppchshh.ahh.spptcpphcpplhsAlpcAhphVpppspc	..........l+NhhEplVhph.lsp.h...........ph..p......t.hspcpls..DlsslALNpLPPhYlppchshh.hth..sptthtphcsclhtAlppAhthltps.p................................	0	52	109	135
+10552	PF10720	DUF2515		Protein of unknown function (DUF2515)	Mistry J, Coggill P	anon	PRODOM_PD131865	Family	This family is conserved in Firmicutes. Several members are annotated as YppC. The function is not known.	25.00	25.00	28.30	28.20	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-11.93	0.70	-5.52	19	260	2009-01-15 18:05:59	2008-06-12 09:26:28	4	2	151	0	33	210	0	311.30	50	86.73	CHANGED	llptIcccTchtNpDNISRTpAYhpaY.RaPEI+WuhLAoMVSRNuGWsMTDL+GphapplLsppppcthFLhYERANWlIFpDAYPQLLLYE.S++pspPLFHLLshFpVSpFMppEWp+FWcctspcRLhhALIINEQNhIQpPlIppsha++pVFcol.Fhlp-hhHFssVlFPshcG.......tLaGholpcFpslccRIpLGKpLupLLFcsch.hsphhcFAhpssHTGSRhDY.pahh.......................Gsp+htSPtLRpsasslsHphssp.pDWFpcpt..shhh.hppp.scphclT-hYh+Kpcplphhhhlpc	......llppIKcpTchhNtsNloRTpAYhpaYhRasEI+WAhLupMVSRNuGWNMTDL+GchYsplLscpsppphFhhhERuNWLIFpDAYPQLLLYEpSp++ppsLFHLLsahNVStFMEp.WphF..Wc.................ptst.ppLhhALIINEQNhlpK.VIpNsaFKKpVhpohhFKLp-hhphspllFPhh.Es...................hLaG.olppFpoLpcRItLGK+LhuLL.F+spa.huphhpaAtppsHTGSRtDY.salh..........................suh+haSPsLp.sa.shtHcEhc....h.cDWFscht..shha.hccE..phpspITE.Yp+phEpIthA.lsp.+................................	0	8	20	21
+10553	PF10721	DUF2514		Protein of unknown function (DUF2514)	Mistry J, Coggill P	anon	PRODOM_PD034813	Domain	This family is conserved in bacteria and some viruses. The function is not known.	24.70	24.70	24.80	24.90	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.01	0.71	-4.54	17	309	2012-10-02 17:03:51	2008-06-12 11:24:49	4	3	255	0	30	214	1	150.60	41	93.15	CHANGED	WhhhhhlllLshs.hhsh....a...ttGpphpstsatpchA..........cccus....pt.stltspstARtcEQcRptAtscstpcAppctstApAsAssAsAuuspLRppsscL....suuppt.ssssuAsspupsAucsuhVLu-lLu+usppAtpLActuDcuplAG.sCE+tYDulpt	...........................................................h...hhhllhhshh...G.........a....hhGsshuDp..uWppK.WA..........-RDuu......t.oppl.ssphuA.Rh.hEQtRphApDEssKDAQpctAchp..AcAAs...hus.uss..pL.Rs-up+h....lsA..A+c..sushAAAspuKospsstshLsshLG-hstcApha.AchADcpa..hAGhTCpphY-olp.s...............................................	0	3	8	19
+10554	PF10722	YbjN		Putative bacterial sensory transduction regulator	Mistry J, Coggill P, Bateman A	anon	PRODOM_PD093695	Domain	YbjN is a putative sensory transduction regulator protein found in Proteobacteria. As it is a multi-copy suppressor of the coenzyme A-associated temperature sensitivity in temperature-sensitive mutant strains of Escherichia coli the suggestion is that it both helps CoA-A1 and possibly works as a general stabiliser for some other unstable proteins [1]. This family was expanded to subsume other related families: DUF1790, DUF1821 and DUF2596.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.20	0.71	-4.10	185	1845	2012-10-01 22:01:34	2008-06-12 12:57:55	4	8	1501	2	429	1139	363	127.10	20	69.51	CHANGED	sh-hlpphlpptshp.....hph.....tp-.spts..............ltsphpshthhhhhts..........pspthth.......shsh.hphs................pptsthhphlsphNpphhhs+h..hh.pppsthh.....hchslsl.....ttulospplpphlptshptsppahstlpt	.....................................................................phlcphlpphshp.....a.p....sss.spuh............hhsphpsh.p..hhhshp............-h.s.hl....hhu.h.h.tcl................sssh.slhthLsthNt...pt.hhs+h...hl..ctp..scsh...........lptslsl......tGl..o....c..p.h..t..hhlpps.cthphhh.....t..................................	0	128	285	369
+10555	PF10723	RepB-RCR_reg		Replication regulatory protein RepB	Mistry J, Coggill P	anon	PRODOM_PD763888	Family	This is a family of proteins which regulate replication of rolling circle replication (RCR) plasmids that have a double-strand replication origin (dso). Regulation of replication of RCR plasmids occurs mainly at initiation of leading strand synthesis at the dso, such that Rep protein concentration controls plasmid replication [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.76	0.72	-4.25	15	388	2012-10-02 18:44:02	2008-06-12 13:18:45	4	3	310	2	20	199	17	75.20	41	85.33	CHANGED	M.....SQhtNAVTSSsssKRtYRKGsPh........osAE+Q+suluRK+tTHKclpVFlpNtLK-pLhplCcccGlTQAEhIEcLIcpEhscps........p	...............................M.SQhtNsVTSSs..KRhYRKGpPl.........osuE+QphuluR..K....+so......+K.....clpVFlpsphKshLtphCcccGlTQAEhlcc.LIcpEhtth..s..............	0	3	7	14
+10556	PF10724	DUF2516		Protein of unknown function (DUF2516)	Mistry J, Coggill P	anon	PRODOM_PD057095	Family	This family is conserved in Actinobacteria. The function is not known.	25.90	25.90	27.00	26.70	24.50	25.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.35	0.72	-4.01	22	270	2009-01-15 18:05:59	2008-06-12 13:23:55	4	2	269	0	89	211	12	99.70	35	97.19	CHANGED	M...............hlhsltshlhhlLtlsshssulaAhlcuAhpRsDAFsAAsKtTKshWLsILGlulhlhllhh........shlshhul.luslAssVYlsDVRPtlcplp.................hssW	........................h.thlhhlLhlssllsulhAhVcAAhpRsDAasAADKhoKshWlsILGsAs.hlshlh......................sslsh.Luh..lu...hlAsuVYllDVRPpltplp...............G.....h.......................	0	25	67	85
+10557	PF10725	DUF2517		Protein of unknown function (DUF2517)	Mistry J, Coggill P	anon	PRODOM_PD055257	Family	This family is conserved in Proteobacteria. Several members are annotated as being protein YbfA. The function is not known.	25.00	25.00	41.40	41.20	20.70	19.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.18	0.72	-4.29	11	540	2009-01-15 18:05:59	2008-06-12 13:48:29	4	2	535	0	42	123	1	62.40	80	92.11	CHANGED	hYpsYPhapIlLRRhhVlLsGlLALPVMLFh..+DRARFYSYLHRVWsKTSDKPVWLpQuEpusp	...LY+-YPAalIFLRRoaAVsAGVLALPhMLFW..KDRARFYSYLHRVWSKTSDKPVWMsQAEKAT.s...	0	1	10	24
+10558	PF10726	DUF2518		Protein of function (DUF2518)	Mistry J, Coggill P	anon	PRODOM_PD032672	Family	This family is conserved in Cyanobacteria. Several members are annotated as the protein Ycf51.  The function is not known.	25.00	25.00	25.20	133.60	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.70	0.71	-4.66	26	73	2009-01-15 18:05:59	2008-06-12 13:59:10	4	1	73	0	29	78	119	145.00	41	86.59	CHANGED	M..shsphltpsstWluauulshulLTllAFlhpWGlRFRLVGlTuFolLLosusaAFulua.ps.stl-GAlphslVaDNGsshlVspsssshsspslpsTLcQlAuNL+usGRsus....pVplRlRplppspsGlScPllLGElpRs	........M.hst.hhshspWhuhuolshslLTllAFlh+WGlRFRLVGlTuFhhlLosuhauhuluh.hs+spI.GAl+aslVYDNGusplVlslssslstsplEATLcQAAsNLhShGRsus..ptplsIRhRslhHspsGlScPlhLGclpR....	0	5	19	27
+10559	PF10727	Rossmann-like		Rossmann-like domain	Bateman A	anon	Bateman A	Domain	This family of proteins contain a Rossmann-like domain.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.57	0.71	-4.41	8	557	2012-10-10 17:06:42	2008-06-12 16:45:08	4	5	547	4	188	1095	262	118.70	31	39.88	CHANGED	MptP...........p.sRLpVGIlSAGRVGsALGtAL-RAGHsVsuloAlScAS+pRAppRLPssslhsl.-lsc+uELllLAVPDA.ELsGlVpGLAsstssRsGpIVsHTSGApGlsILAPLscpGsIPLAIHP	.....................h.....................plGlIG.A.G+VGssLuhsL......p.p........s.......s....a..................l.....s.........u....s.....t........u....h....S.........p......s.........S......t.....p.....c.....A....t.....p.......h.....l..s....s............s.......s.......h............h.......s...............t....-...l.......s.......s..p...u..-.LlllsV.P.Ds...tl.ss.l.s....p....t...L...s.....t..t...t.....hp........s...G...p........l.ls.H..s..SG...A..h...u..ss.lLsP.hpptGu..hshulHP......................................................................	1	69	144	174
+10560	PF10728	DUF2520		Domain of unknown function (DUF2520)	Bateman A	anon	Bateman A	Domain	This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.	22.20	22.20	22.40	31.20	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.46	0.71	-4.70	98	840	2009-09-11 11:03:44	2008-06-12 16:53:23	4	12	824	6	260	779	206	129.80	28	45.49	CHANGED	ssshulEu...sppshslhp.plspplGscshhl.sscpRshYHsAAVhuuNalssLhshutclhpps..Glst.......................chLtPLlcsolcsh.hphGs.pALTGPls......RGDts.....TlppHlpsLpp.........sphtplYptLucthh	...............sshsl-u...sptsh.th.hp....sLstplGscshtl...spp.pRhhYHAAushuuNalsslhs..uhclLppt....Gls.......................................................................chLhPLlpsslcsh.hp.....p............G......p...............ALTGPls......RGDts.....slppHLphLps............sphtphYphhupth.h................................	0	101	200	242
+10561	PF10729	CedA		Cell division activator CedA	Pollington J	anon	PRODOM	Family	CedA is made up of four antiparallel beta-strands and an alpha-helix. It activates cell division by inhibiting chromosome over-replication. This is mediated by binding to dsDNA via the beta-sheet. [1,2].	25.00	25.00	79.50	79.40	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.74	0.72	-4.43	3	438	2009-01-15 18:05:59	2008-06-19 16:21:05	4	1	434	2	15	70	2	79.30	91	97.33	CHANGED	lMKPLRQQNRPIISYVPRVEPAPPEHAlKMDuFRDVWhLRGKYVAFVLMGEHFRRSPAFSVPESAQRWANQIRQEGEIpE	MKKPLRQQNRQIISYVPRTEPAPPEHAIKMDSFRDVWMLRGKYVAFVLMGESFLRSPAFTVPESAQRWANQIRQEsEVsE.	0	1	1	8
+10562	PF10730	DUF2521		Protein of unknown function (DUF2521)	Pollington J, Finn RD	anon	PRODOM	Family	Family of unknown function specific to Bacillus.	25.00	25.00	115.60	115.00	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.90	0.71	-4.38	10	131	2009-01-15 18:05:59	2008-06-19 16:34:35	4	1	131	0	18	56	0	143.40	62	99.77	CHANGED	MsVIsSFs-++REKQlcaEKplLRELSLcplppul+caFtsl.asFhpphpshlp-uCIDhAIEAYLLGu+aG+FGYYGEshpclptRstcEEccLscsLasaLpsWup.tpsptsp-sLYtAscpFIssWWpEGFpcucKRaKLRLH	...MNVIVSLpEKQKEKQLKYERKMLRELSLKTLRoNIRDAFp......MQELHRQYEDYCIELGIESYLLGARYSKFGYYGESFFDVKYRALEEEQQLTETLFQFLTSMThREIcLpDEELLFESCQQFIGhWWQEGYEKGERRYRLKLH.	0	3	10	12
+10563	PF10731	Anophelin		Thrombin inhibitor from mosquito	Coggill P	anon	Rawlings N	Family	Members of this family are all inhibitors of thrombin, the peptidase that is at the end of the blood coagulation cascade and which creates the clot by cleaving fibrinogen.  The interaction between thrombin and fibrinogen involves two different areas of contact - via the thrombin active site and via a second substrate-binding site known as an exosite.  The inhibitor acts by blocking the exosite, rather than by interacting with the active site.  The inhibitors are from mosquitoes that feed on human blood and which, by inhibiting thrombin, prevent the blood from clotting and keep it flowing.	25.00	25.00	27.70	105.10	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.09	0.72	-3.87	4	8	2009-09-14 14:04:23	2008-06-19 16:55:34	4	1	5	0	1	8	0	64.60	58	71.31	CHANGED	MAoKLlVIAhLClALlA.lVQuAPQYApG-EPoYDEDD.s-EslpPHSSSssD-s.--FDsSLL-c	MAoKLFVIAhLClALVA.lVQuAPQYApG-EPoYDEDD.s-EsLpPHSSSsoD-s.-EFDsSLL-c.	0	0	1	1
+10564	PF10732	DUF2524		Protein of unknown function (DUF2524)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillaceae bacteria. 	25.00	25.00	73.70	73.50	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.92	0.72	-3.86	8	132	2009-01-15 18:05:59	2008-06-23 11:22:36	4	1	132	0	18	52	0	84.00	70	93.53	CHANGED	MATRQSV-EaLQ+sEpAl-aApEQacpAp+QEHYN-pEYS-AQhhLEsAVN-Ls+LshSAN-QQREQLaRhRLQLQpLQNpMIL	.MAERQSLEsYITQAEQAVEYAKEQL-pGMRQEHYNTMEYSDAQLQLEQAYNDLQsMQQHANDEQREQLNRARMAIRQLQHQMII.	0	2	10	12
+10565	PF10733	DUF2525		Protein of unknown function (DUF2525)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.	21.40	21.40	21.60	24.40	21.30	18.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.64	0.72	-4.13	4	435	2009-01-15 18:05:59	2008-06-23 11:30:14	4	1	433	0	18	61	0	57.80	90	76.89	CHANGED	DVDALLAAINEISESEVHRT.-Dsp+sslDGRchHTaRELAEAFELDIHDFSsSEVNR	.DVDALLAAINEISESEVHR..S..QND..SE..HVSVDGREYHTWRELADAFELDIHDFSVSEVNR...	0	1	1	11
+10566	PF10734	DUF2523		Protein of unknown function (DUF2523)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of phage related proteins whose function is uncharacterised.	21.30	21.30	21.30	21.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.32	0.72	-3.75	28	269	2009-01-15 18:05:59	2008-06-23 11:32:35	4	1	213	0	36	185	2	82.70	23	83.97	CHANGED	tsLhshLtslht.lls+l..LsulGluhsohsGlsshhsthht.htshhsulPs....sllslluhhGlspuluIIhuAlshRlshpsl	....................................h..LhshLh.lht.llh.+l........lhulshhhhs.h....ssl.thhs........hh....shlpsthsulPs...........shhthlhhhGlspuLshlhuAhsh+huhp..h......	0	8	20	28
+10567	PF10735	DUF2526		Protein of unknown function (DUF2526)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function is restricted to Enterobacteriaceae. The family has a highly conserved sequence.	25.00	25.00	49.60	49.50	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.51	0.72	-3.99	3	445	2009-01-15 18:05:59	2008-06-23 11:37:21	4	1	444	0	16	60	1	76.60	90	99.99	CHANGED	MSHLEEVpsRVDAAIAEuVIAHMNELLIALSDDAQLSREERYsQQQRLRTAIAHHGRQHKEDpE....ARREQLTKGGoIL	MSHLDEVIARVDAAIEESVIAHMNELLIALSDDAELSREDRYTQQQRLRTAIA.HHGRKHKEDME....ARHEQLTKGGTIL...	0	2	3	10
+10568	PF10736	DUF2527		Protein of unknown function (DUF2627) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to a family of Enterobacterial proteins. It has a highly conserved sequence.	25.00	25.00	29.40	48.80	16.40	15.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.80	0.72	-4.34	2	354	2009-09-11 09:21:57	2008-06-23 11:38:56	4	1	354	0	9	18	0	37.80	95	81.88	CHANGED	MCGIFSKEVLSKcVsVEYRFSA-PYluASsSNsSsLSM	MCGIFSKEVLSKHVDVEYRFSAEPYIGASCSNVSVLSM...	0	1	2	4
+10569	PF10737	GerPC		Spore germination protein GerPC	Pollington J, Finn RD	anon	PRODOM	Family	GerPC is required for the formation of functionally normal spores. The gerP locus encodes a number of proteins which are thought to be involved in the establishment of normal spore coat structure and/or permeability, which allows the access of germinants to their receptor [2].	22.40	22.40	24.20	23.30	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.15	0.71	-4.50	8	149	2009-01-15 18:05:59	2008-06-23 12:10:43	4	2	142	0	20	99	0	167.80	53	85.78	CHANGED	IppLE+plpELQpElspLKp+PuTsI-RIEYKFDQLKIEpLEGTLNIGLNP.oDsp.slEsFpV.ssssssluhhpQ-pssplhppIcQpV-tYLsEEsPplLcpLEppY-spLD-o.+paIlEDI+KQhDSRIcYYlpphtpcpsssPspc....t-cIAptVK+DIp+Al-pFLpHIPs	......................................IhsLEcQV+pLQcELNEL..KsR....P....So....SIsKVEYK..FDQLKVEsLsGTLNIGLNP..uc..sp...pIEDFpV..-sETl.cVs.............PEs...-ssPcaaQ........sIhQchacYL-EEAhscIh+hEpcp.cosLDEhYRQhhl-DIKKQM-cRlsYYLSQsp...shEsh........sossc..hlc-hIlQthKpDI-+Ah.uFIpHIPu.................	0	4	12	14
+10570	PF10738	Lpp-LpqN		Probable lipoprotein LpqN	Mistry J, Coggill P	anon	PRODOM_PD017067	Family	This family is conserved in Mycobacteriaceae and is likely to be a lipoprotein [1].	21.60	21.60	22.00	22.20	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.27	0.71	-5.01	19	257	2009-01-15 18:05:59	2008-06-24 13:21:36	4	3	90	0	49	152	0	179.40	35	72.00	CHANGED	ssssP..................................lspaLcppGVshps.sPpshsuLslolPhPsGWpshssPNlssuhslI.....upuhhhssApllVaKLhGsFDPscAIp.HG.sDuQth.sac.phsAShAsasGFPSShIEGoYc.sGhphpo.pRhVIATu...usp+YLVpLoVT.ohsspAs.stusss-AIlsGFpVus	...............................................st..shP.........tholt-YlcspuVphpPlpsss.su.slslPhPssWp...hs..sss..lsssassIs.p...usus.....sPsA.hllVhKLp.G.DhD.PAcslp.+uss-.uppLsuap...sssuShAsasGFPSu..h...lpGoYcp.s.Gh....p.hpsupRpVlssu.....sssp.YLVpLs..lT.shsspus.shusAscsIspGhpls.s......................................................	0	5	27	42
+10571	PF10739	DUF2550		Protein of unknown function (DUF2550)	Mistry J, Coggill P	anon	PRODOM_PD031809	Family	This family is conserved in Corynebacterineae. The function is not known though most members are annotated as either secreted, or membrane, proteins.	20.60	20.60	20.70	22.10	18.00	20.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.59	0.71	-4.19	20	360	2009-01-15 18:05:59	2008-06-24 13:38:10	4	1	358	0	88	232	1	130.70	34	85.61	CHANGED	sLslllssllhlh..lhRhhlhRphGuhssslR.....hsssss+GWphGlhRYssscLcWaRLhSLpstPchslsRpul-lhsRRsPpusEhhhlssssl.llc........lps....cs.sphElAhstsAhTuFhSWLESuPssp	..........lsslllhh.hhhh....hhRhh....hhRp.GuhssslR........sh.s.....uss.spG.WphGssRYs.ss.phcaYRlhSh+hhPshhLpRpulclh..s+..RsPp.s.-Ehhhhsssh..h..llp........lps...................+s.sshElAlDtsulTuhhSWLEuAPss.t.......................	1	28	67	84
+10572	PF10740	DUF2529		Protein of unknown function (DUF2529)	Mistry J, Coggill P	anon	PRODOM_PD099482	Family	This family is conserved in the Bacillales. The function is not known. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.08	0.71	-4.83	14	343	2012-10-02 15:05:26	2008-06-24 13:41:14	4	1	343	2	29	139	0	168.40	53	97.13	CHANGED	M.KIFoTQLoGlFsRIt-KEp.uIEDuARLLAQAllG-GplYltGhsEhpulthpAhputEshsSutsLs.sss...plssoDRVLlFsphssDtEshthscpLh-pGlshVslS.sstpcssslsphsclHIDhplptsLlPsED.GsRhGaPushsuLYlYauLphslcEhL	...............................................MSKILsTQLhGIFNRl.EKQpL-IpMAAQsLlQ.AIGGEGaVYlKGYcDLpaaEoa.....lLaScE+LKSS++Lc.sl...pchpEIDSTDRVLLFuPFYsD.pVshDlpKLl-hDlDlVLIS....N.......pPKT-....DhP-HLsHaIDLSTPRPIVYTED..Y.DKIlQPHsMAhNYlYY-IYTQMlEMs.........................	0	7	16	23
+10573	PF10741	T2SM_b	GspM_II;	Type II secretion system (T2SS), protein M subtype b	Mistry J, Coggill P, Desvaux M	anon	PRODOM_PD110875	Family	The T2SMb family is conserved in Proteobacteria and Actinobacteria, and differs from the T2SM proteins in Vibrio spp. (Pfam:PF04612).	21.50	21.50	21.50	21.50	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.08	0.72	-4.44	28	187	2012-10-02 17:03:51	2008-06-24 13:57:02	4	3	172	0	71	217	26	108.80	24	55.89	CHANGED	tusssaltusssshAuAsL.p+lpshlsps...GsslsooQhhs..sspup.....hsplulplshcsshssLpplLhsLEsupPhLaVDpLslps.......shsssssups..Lplphsluuhh	........................t.t..al.st.ssshAuA.sL.pclpphlsps...Gs..ssttsphhs..hp...s.psp..............hsplslplplps....sh..tsLtslLhsLEstp.PhLhl-pLslpt..............phttssstts.tLplthtltuh...........................	0	24	42	58
+10574	PF10742	DUF2555		Protein of unknown function (DUF2555)	Mistry J, Coggill P	anon	PRODOM_PD060530	Family	This family is conserved in Cyanobacteria. The function is not known.	25.00	25.00	74.40	74.30	24.40	19.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.62	0.72	-4.34	21	69	2009-01-15 18:05:59	2008-06-24 14:57:06	4	1	69	0	28	62	107	56.90	55	77.10	CHANGED	lot-plssFscpslApLApRLE-DDYssPF-GLpDWHLLRAlAhpRPELspPYlHLl	....otcclsuhTpp-VApLApRLEpDDYssPF-GLpDWHLLRAlAFpRPELscPYlHLL.	0	5	18	26
+10575	PF10743	Phage_Cox		Regulatory phage protein cox	Mistry J, Coggill P	anon	PRODOM_PD064131	Family	This family of phage Cox proteins is expressed by Enterobacteria phages. The Cox protein is a 79-residue basic protein with a predicted strong helix-turn-helix DNA-binding motif. It inhibits integrative recombination and it activates site-specific excision of the HP1 genome from the Haemophilus influenzae chromosome, Hp1. Cox appears to function as a tetramer. Cox binding sites consist of two direct repeats of the consensus motif 5'-GGTMAWWWWA, one Cox tetramer binding to each motif. Cox binding interferes with the interaction of HP1 integrase with one of its binding sites, IBS5. This competition is central to directional control. Both Cox binding sites are needed for full inhibition of integration and for activating excision, because it plays a positive role in assembling the nucleoprotein complexes that produce excisive recombination, by inducing the formation of a critical conformation in those complexes [2].	23.70	23.70	23.80	28.90	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.87	0.72	-3.96	6	218	2009-01-15 18:05:59	2008-06-24 16:14:00	4	1	186	0	11	94	0	81.20	49	85.59	CHANGED	M.......ppQlophsoDhlsh-tFAphIGKTspAVppMlcAGKLPslcMpDPppssG+.GEhWlahsEWsphs+phh-otPsE....WhhWhsh	...............lhth.hDAl.hpcFAchlGKs.sAVppMlctuKLPlI-h.p.DPppssuRAGEhWValPtaNcul+pAa.sRPhE.RDuWLhWhGL.......	0	1	5	8
+10576	PF10744	Med1	Med1-Trap220; 	Mediator of RNA polymerase II transcription subunit 1	Wood V, Coggill P	anon	Pfam-B_51442 (release 22.0)	Domain	Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II.  This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions [1]. Med1 is part of the tail region of the Mediator complex [3].	21.10	21.10	21.30	21.50	20.40	21.00	hmmbuild  -o /dev/null HMM SEED	393	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.24	0.70	-5.70	30	276	2009-01-15 18:05:59	2008-06-24 16:21:09	4	5	202	0	189	267	0	357.00	20	39.21	CHANGED	l................s-hlphlhthh.tth..............sl-slp+hsphhuh-uhs-cl.....................clshtpshlsl-lDhspt.pshlhsstLhl........................................th.hss.psphsphphuh.tp...ps.stLhphhptpshscFppsLphLspl.phss...........................................p.ptchshFtAlcsLtpsLp........th.ph..pptsss.phpphhpsshGhhthc..pss....chthplpYahpst.lhctpp...........................................h..shphhtssthtshhNpssphpsssssthh.hhs..hs.........P.hhh.sppsssphssshshhlspshs...................................................................................pt.h..h.....st.ppapYths........sshps.tsph.lpclshscspplstllsl.............................................LRp.sh..hssLlposhpppt	..................................................................................................................phhphlp.hh.t................sh-sl.p+hhp.h.uht..shh-ch....................................p..htt.ph....ls.........clsh..stt....p....shlpsshhhh..........................................th..s.s.tsphs...sh.phth...tc..............ps...........t.h....spth...p.t...........pshspFptpLctLspl.pLst.................................................................................p.chpha.AlpultpsLp........................ph..h....ph..........................p.........t.s.s.........t.........t............hp.........p......h.h.pup.h.Ghht.+....pss....+l.hslpYahs.tplhptpp................................................................ht...h......ts.......sht...hstssp....tss.st....hh...hh.......s.hhts..............Psh......spsspsphs..s........sh.hphspshs...sht.lttht.sh.hsh................................................................h....tpt............tpp.t.h..h..sh...........s..t.....ppHsYhh................shpsh.Gph...lpclsFpHPtplshllsl.............................................LRp.sh..hssLltsshp...s...............................................................................................................................................................................................	0	46	83	151
+10577	PF10745	DUF2530		Protein of unknown function (DUF2530)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to mycobacteria.	22.40	22.40	22.40	23.00	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.55	0.72	-4.00	10	133	2009-09-11 11:12:09	2008-06-25 13:38:17	4	1	133	0	42	94	37	75.50	49	87.02	CHANGED	sspPPPLPssLL-PhPVIsVGsLuWLV.AsVsAFsVsu.LcsWRPlTlAGLuVGlLGToIFLWQR+AARRGuRGAQsGL	...............h..psPsLPssL.l-shPVIsVGsluWLV.As..V.sAal.Vsu...l....s.....s.....WpPV..olAGLusGl.LGTsIFlhQhuAARRGuRGAQtGL.........................	0	12	31	38
+10578	PF10746	Phage_holin_6		Phage holin family 6	Pollington J, Finn RD	anon	PRODOM	Family	Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis.	20.10	20.10	20.90	20.60	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.21	0.72	-4.25	4	52	2009-01-15 18:05:59	2008-06-25 13:44:29	4	1	39	0	1	40	0	62.70	52	94.44	CHANGED	LpLDFsNEVlKAAPIVGTusADsAuRlFFGLoLNEWFYsAAIAYTVVQIGshVhcslhc.K+tsKs	.....................LsLDFNNEll.KAAPlVGsusADsuARLFFGLSLNEWFYVAAIAYTVlQIGAhVhcplhcaK+ts+..........	1	1	1	1
+10579	PF10747	DUF2522		Protein of unknown function (DUF2522)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus.	25.00	25.00	43.10	43.10	24.00	23.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.84	0.71	-4.15	12	130	2009-01-15 18:05:59	2008-06-25 13:45:38	4	1	129	0	20	70	0	140.40	55	97.14	CHANGED	RpY.lYLIc-EhApaYFGREphhFcLFp-hchss..tppcplhtKQlpYITcslPhh+hcptLpptL.s+.hphpphpshapl....stcuputlhlt-+hIpltspGshsAEoshFElLRKlsssFLAhDhpsp+aGWLs.Pl+tcp	......+TYELYLIpEDlA+uYFGREhLFF-LFscao-Su.ohSEKcVLhKQhhYIThPLpVh+IHH+LEQsLcsh.u+YcRs+aTHsL...aoGApauEIMVKs+YIchsoSGNlShETTFFEVLRKsEhTFLAMDYENsKYGWLN.PLKQs.+...	0	4	12	14
+10580	PF10748	DUF2531		Protein of unknown function (DUF2531)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	22.00	22.00	22.00	22.80	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.95	6	489	2009-01-15 18:05:59	2008-06-25 13:47:50	4	1	480	0	33	166	0	125.50	64	94.58	CHANGED	pspRWlLLshsLshLTGMRDPF+PPEDRCRIucLspWRYQGhVucG-plsGlLKDuQpKWRRVcpsphL.sGWplspLTAsplsLpTGcGC-PspWRWpRpGspsE.AMDSpsssssssRtttu+usppDAsGG	................+spRhl.L.hsluLs.LLTGMRDPF+P.P.E.D.h.C..R..I..u..E.L..S..QWRYQGhVG+GERhIGlIKDGQ+KWRR.VppsDlL.E.N.G.WTIlQLTs-sLTLsT...GsN...C..EPPQWhWQRQ.Gc.s.NE.AMD...S...+sTssuD.sRRTGGKuucSDAsG...............................	0	2	7	20
+10581	PF10749	DUF2534		Protein of unknown function (DUF2534)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	21.40	21.40	22.20	53.20	20.40	21.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.59	0.72	-4.06	4	453	2009-01-15 18:05:59	2008-06-25 13:49:56	4	2	450	0	21	70	0	83.00	86	88.81	CHANGED	MIhhtKLpotcGKKFLluLhlVFhlAhoVVuRAThsGVlEQYNhPhScWToSMFhlQuAMlhVYSlVFThLlAIPLGhaFLGuc-	.........MIMAKLKSAKGKKFLFGLLAVFIIAASVVTRATIGGVIEQYNIPLSEWTTSMYVIQSSMIFVYSLVFTVLLAIPLGIYFLGGEE..	0	1	1	11
+10582	PF10750	DUF2536		Protein of unknown function (DUF2536)	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp. Structural modelling suggests this domain may bind nucleic acids [1].	20.50	20.50	23.30	22.50	20.20	17.30	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.14	0.72	-4.39	8	132	2009-01-15 18:05:59	2008-06-25 13:52:36	4	1	132	0	21	57	3	67.80	71	93.71	CHANGED	MNFpLDLIcDKVEFFEApcLpsLEKKIN-QIEpNKAILLpVHsVSHQspVs.csGRhhYSAVVHFKAKp	....MsFoF-MLEDKVEFFEAuDLsSLE+KIuEQID..NNKALMLEVHHISHQMlhDPESKRPYYSAVVHFKLKK....	0	5	13	15
+10583	PF10751	DUF2535		Protein of unknown function (DUF2535)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	82.70	82.60	21.70	18.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.97	0.72	-3.84	9	124	2009-01-15 18:05:59	2008-06-25 13:53:25	4	1	123	0	16	49	0	82.80	65	95.60	CHANGED	MLhKSLEFKpssGppVKloEIPVLcpDpPahFhlphRLphaltclapupsp+sVYSFR-YLKRplKWsDYpplappstLKHNA	..ITKSFYFTHSTGpCIKIFEIPVLQuQHPLuFLIQSRLQLFIAKIQKpK+PRFSYSFREYLQsCLKWNDY.NVYKTNTLEKNA	0	2	8	10
+10584	PF10752	DUF2533		Protein of unknown function (DUF2533) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	48.10	48.00	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.80	0.72	-3.68	10	130	2009-01-15 18:05:59	2008-06-25 14:56:50	4	1	130	0	17	59	0	83.60	69	94.30	CHANGED	hpVH+AITAHS+KQ+pplKpFlpLDtcREtAIE-AVscC+pGcsFoTDsINcITccMN-LAKpGIVPpRKlVTsEMV+EYVuRh	.MEVHKAITAHSRKQNEuVKAhLQLDAQREAAIEAAVSLASNGKcFSVDlINsVTKQINsLAKN.G.Vo.QRKYVTcEMVMEYVSRL.	0	3	9	11
+10585	PF10753	DUF2566		Protein of unknown function (DUF2566)	Mistry J, Coggill P	anon	PRODOM_PD060138	Family	This family is conserved in Enterobacteriaceae. The function is not known.	22.10	22.10	23.00	23.00	22.00	20.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.91	0.72	-4.05	7	798	2009-09-11 10:22:14	2008-06-25 16:39:19	4	1	477	0	30	144	2	53.90	69	84.61	CHANGED	hapthLlhYhlGhslohhlhahlS+D.phpIRhluAhllGlTWPhShPVsLLhSLF	......Lap+hLlFYslhssIuFlIhWFlSH-.Kp+IRhLSAFLVGhTWPMShPVALLFSLF............	0	2	7	17
+10586	PF10754	DUF2569		Protein of unknown function (DUF2569)	Mistry J, Coggill P	anon	PRODOM_PD088965	Family	This family is conserved in bacteria. The function is not known, but several members are annotated as being YdgK or a homologue thereof.	25.00	25.00	25.10	25.70	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.84	0.71	-3.99	15	609	2009-01-15 18:05:59	2008-06-30 10:56:40	4	5	578	0	63	219	7	142.60	64	86.26	CHANGED	ssshp+IGGWLlh.PhshLllo.lss.lsllhhh.ulhsstsaphLsupssshh.....hhhhhullhslsMa..........haTLalshLFF+R+pthP+haIlhlLloll.lslcuaAh........oPl.DshAl+plhhsLLuAslalPYh++ScRVKpTFlc	............T.TsPQRIGGWLLG....PLAWL.LV.AL......LSso......LA.L....L.LY...ssALuoP.QTFpTLuuQuhssp..........lLWGlSFITAI.....AMW..........YYTLWLTIAF..FKRR.RCVPK.HYI..I.WLLlSVL....L..AVKAFAF............SPVpD...ul.A..VRQLLF.....sLL..ATALIVPYFKRSuRVKsTFVN...	0	10	20	42
+10587	PF10756	bPH_6	DUF2581;	Bacterial PH domain	Mistry J, Coggill P, Bateman A, Ginalski K	anon	PRODOM_PD034109	Domain	This domain has a bacterial type PH domain structure. This domain was previously known as DUF2581. This family is conserved in the Actinomycetales.  Although several members are annotated as RbiX homologues, RbiX being a putative regulator of riboflavin biosynthesis, the function could not be confirmed.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.28	0.72	-4.09	95	695	2012-10-04 00:02:25	2008-06-30 11:00:18	4	2	302	0	232	583	18	75.20	24	44.92	CHANGED	RsRltlsssG..lslRslh.us+hlsWs-Itslp...hspusph...........sclchsD....sphlsl.ulphs.st.ptshsuhsplt.s	..................RsRlts.sscG....lslRshh.ss+hlsWsplt.ulp..........hspu.sph........................................splchs-..................sph.lsl.u.lphs.sh.thshsuhtth...s........................................................................................	0	71	179	218
+10588	PF10755	DUF2585		Protein of unknown function (DUF2585)	Mistry J, Coggill P	anon	PRODOM_PD589556	Family	This family is conserved in Proteobacteria. The function is not known.	25.00	25.00	38.50	38.10	17.70	16.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.22	0.71	-4.80	20	70	2009-01-15 18:05:59	2008-06-30 11:03:00	4	1	69	0	27	80	10	161.90	57	83.99	CHANGED	lLhuMGRsPICsCGhVKLWcGsltSucNSQHluDWYT.SHlIHGFLFYuhsaLlhtRhs........huhR..LhlAlhlEuAWEIlENSshII-RYRsuTIuLDYhGDSllNSluDhlhMllGFlhAuRLPValTVslAIuFElhsuhlIRDNLTLNVLMLlaPlEAI+pWQuG	...............LahMGRlPICpCGh.VKLWcGsVsSStNSQHluDWYT.SHlIHGFLFYuLsaLlht+tP..........huhRLhlAhlIEuuWEllENSPhII-RYRsuTIuLDYaGDSIlNSshDTlhMhlGFlhA.tRLPVhlTVslAIsFElhsuhhIRDNLTLNVlMLlaPl-AIKpWQuG.................	0	6	14	18
+10589	PF10757	YbaJ		Biofilm formation regulator YbaJ	Pollington J, Finn RD	anon	PRODOM	Family	YbaJ regulates biofilm formation. It also has an important role in the regulation of motility in the biofilm. YbaJ functions in increasing conjugation, aggregation and decreasing the motility, resulting in an increase of biofilm [1]	25.00	25.00	35.80	35.80	21.20	18.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.63	0.71	-3.98	4	531	2009-01-15 18:05:59	2008-06-30 11:44:24	4	1	529	0	38	112	3	120.80	84	98.44	CHANGED	MDEYSPKRaDIAQLKFLCEsLYDEuIAoLG-SpHGWVNDPTSAlNLQLNELIEHIAoFllsFKIKYss-u-LoEQlEcYLDDTasLFSSYGINs.-LQRWpKS+pRLFthFSspplCT.hpT	..MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYLDDTFMLFSSYGINhQDLQKWRKSGNRLFRCFVNAT+pNPsS.L.......	0	1	8	23
+10590	PF10758	DUF2586		Protein of unknown function (DUF2586)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.20	20.20	20.30	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	363	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.04	0.70	-5.40	17	164	2009-09-13 14:48:51	2008-06-30 11:53:10	4	2	148	0	26	149	4	324.10	34	83.60	CHANGED	uhGpVplNsLN.hQGshsplERphLFIGhus.p...N.hGpllslssQSDlDslLGtuDSsLKppltAAphNuGpNWsAhshslss-sp...a.sAlctA.ppshSsEuVV....lsssssspAplsshpstts-LhspaGRhVahlsAssGl......spspoWusYhsthssLppGlAuppVtlVPpLa..GsplGllAGRLCscuVoIADSPMRVtTGullG.LG....shPhDpsGh.LshAsLpuL-ssRaSVPtaYPDY-GhYWuDGphLDs.GGDYQsIEsLRVVDKAARpVRIlAIt+IuDRsLNSTPsSIAsscsaFu+PLR-MS+SsphsGppFPGEIcsPpDsDIsIsWho+ppVpIalhVRPYssPKpITssIhLD	.............................................................................................................................hspVplsthN.h.G.htplEphhLFlG.us..p...s....sphh.lsspoDhsthl...u.tss.L+t.lhAA..Nusps...W.uhs.h.lstssp............a.pAlctA.ptshShEhVl....lstss.sspsplsthtshttcLhsphGRhlahlhsstu.........tpspsWs-YhsthsslppulAsptVtlVPp...La...........G..sp..........Gl.l.AGRLs..sp....u....Vo...........lADSPsRVtTGull..s.ls......phPhDtsG..t.t.ls...hA...sLpuL-ssRaSVPhWYsDY-GhYWuDGpTLDspGGDYQsIEslRVlcKAuR+VRlhAIs....+I.u.D.R.s....LNST.....s..s...S.lssppphFs+sL..RcMup.usplsu....FP..G..Elh....sPpDs......DlsIhW.spptVplhhhlcsapsPhpIslsl.LD............................................................................................	0	6	15	19
+10591	PF10759	DUF2587		Protein of unknown function (DUF2587)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with no known function.	25.00	25.00	99.70	99.30	17.50	17.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.20	0.71	-4.87	15	199	2009-01-15 18:05:59	2008-06-30 11:59:36	4	1	198	0	76	162	39	164.30	68	89.78	CHANGED	GPDG.....................sspusp-.sscstspslsDLVEQPAKVMRIGoMIKQLLEEVRAAPLDEASRsRL+EIHcoSI+ELEDGLAPELhEELERLoLPFo--ssPSDAELRIAQAQLVGWLEGLFHGIQTALaAQQMAARAQLEQMR..ptALPsGhs.s..........pGpsptsttuts.G..s...........GQYL	............................sssthhs..............sp..-s-sccpulTDhVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRsRLREIHtoSI+ELEDGLAPELREEL-RLoLPFsED..us...PSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMAARAQLEQMR.....pt...ALPP.Gsutsst........tG.......................................h.......................	0	23	58	72
+10593	PF10761	DUF2590		Protein of unknown function (DUF2590)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	20.10	20.10	22.30	31.00	17.40	18.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.27	0.72	-4.29	18	127	2009-01-15 18:05:59	2008-06-30 13:00:03	4	1	114	0	21	86	3	99.70	49	93.49	CHANGED	lDLhIhssDlsLDuuspPhllssRsoIAQDIKHtIhESGLshpLIuERushhpsDhhpplELlVE-DtRLVPGTlplsEsssGplhlTApTh-aG....lslclsh	.lDLLIpssDhsLssGspPhhCssRtSIuQDIhHuIlESGLsscLlAERSPshRuDlhpphcLLlEsDcRllPGTlplsEp....s...splalTApTaDFG..slshpl.h........	0	5	12	14
+10594	PF10762	DUF2583		Protein of unknown function (DUF2583)   	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as YchH however currently no function is known.	25.00	25.00	51.90	51.80	23.20	19.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.83	0.72	-3.85	5	543	2009-01-15 18:05:59	2008-06-30 13:04:58	4	1	530	0	40	129	1	86.10	83	96.79	CHANGED	MKRKNAutLGNVLMGLGLVlMVsGVGYSILuclsQFNlPQFFAHGAllSIFVGALLWLVGARIGGREpVADRYWWVKHFDKRCRRssHR	....MKRKNASLLGNVLMGLGLVVMVVGVGYSILNQLPQFNhPQa.F..AHGAlLSIFVGAlLWLAGARVGGHEQVsDRYWWVR.HY.DKRCRRsDNR............................	0	1	8	23
+10595	PF10763	DUF2584		Protein of unknown function (DUF2584)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins have no known function.	25.00	25.00	25.30	25.90	20.80	18.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.62	0.72	-4.15	9	175	2009-01-15 18:05:59	2008-06-30 13:07:09	4	2	175	8	18	82	0	78.70	58	95.31	CHANGED	MGMPlEhNTMIVTKG+EpR..lEENlFpLEKEGYRlYPl-lPl-VRKTKcGEpoGoAhlpKLEWcsu+TpITYcLlSLpSTN	.............................M.hEhpThIl...op...tKEhR...............I..-.-.NlFpLch-GY+laslp..lslhKopE.EplGoAhlpKLEWENGKTpIsYpLlSLpSsN.......	0	2	10	12
+10596	PF10764	Gin		Inhibitor of sigma-G Gin	Pollington J, Finn RD	anon	PRODOM	Family	Gin allows sigma-F to delay late forespore transcription by preventing sigma-G to take over before the cell has reached a critical stage of development. Gin is also known as CsfB [1].	21.00	21.00	21.10	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.66	0.72	-4.25	21	219	2009-01-15 18:05:59	2008-06-30 13:09:27	4	2	219	0	51	130	0	46.10	44	71.70	CHANGED	hClICcpp+pc...GIhlhs+FICp-CE+cllsspss-spYpaYh++LK	.hCIlCcpc+p-....GIhlhsphICh-CE+chVsT-ssDscY.aYl+pL+.......	0	21	37	42
+10597	PF10765	DUF2591		Protein of unknown function (DUF2591)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.30	21.30	21.80	21.70	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.60	0.72	-3.84	16	234	2009-01-15 18:05:59	2008-06-30 13:18:17	4	1	198	0	36	151	1	106.50	32	91.15	CHANGED	McaScLSDhElNhhVAcApshp..h...........................s.h.hh..ps.sthttas.CssPuDAhPIIpcs+Iul..........tsssscWsAp...................ssssh.hh.spsPLRAAMIVFLh.p	....................................caupLSDhElNphVuth.htps..thh.........................t...s...h...hst...h..s.t.h....tshc.CssPuDuWPIIp+.t.+Iul................h.........sp.tspWsAp.............ssps.sh.h.h.sp...sPLRAAMIsFLh.Q...........................	0	0	9	22
+10598	PF10766	DUF2592		Protein of unknown function (DUF2592)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	25.20	25.30	18.90	24.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.88	0.72	-4.61	5	530	2009-01-15 18:05:59	2008-06-30 13:40:05	4	1	516	0	39	104	2	40.20	89	79.27	CHANGED	LLKSLlFAVVMVPVVMAlILGLIYGLGEVFNIFS+lG+oK-	.LLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGlG+KDQ......	0	2	8	23
+10599	PF10767	DUF2593		Protein of unknown function (DUF2593)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YbjO however currently there is no known function.	23.50	23.50	149.90	149.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.87	0.71	-4.50	6	522	2009-01-15 18:05:59	2008-06-30 13:44:05	4	1	520	0	34	121	2	143.70	77	88.68	CHANGED	hssPs.V.VAulAIIuhRsLslLhLhspLGlcGlu-FIpcSlQsWshTLlFhuSLlLlhlEIhCuFulh+GRNWuRWsaLlsQllssuYLhhASLGahhPElFoIsGES+t-IhHSLlLQKlPDlLlLsLLFlPupSRRFFtlQ	.L.NVPALVQVAAlAIIhIRGLDVLMIhNTLGVRGlGEFIHRSVQTWSLTLVFLuSLVLVFIEIWCAFSLVKGRpWARWlYLLTQIsAuuYLWAASLGYGY..PELFSIsGESKREIFHSLhLQKLPDhLILhLLFVPuoSRRFFpLQ.....................	0	1	6	19
+10600	PF10768	FliX		Class II flagellar assembly regulator	Mistry J, Coggill P	anon	PRODOM_PD868899	Family	The FliX protein is possibly a transient component of the flagellum that is required for the assembly process. FliX may contribute to the targeting or assembly of the P- and L-ring protein monomers at the cell pole. The family carries a potential N-terminal signal sequence and at least one transmembrane domain indicating that it might function either in or in association with the cell membrane [1].	25.00	25.00	40.10	39.90	21.20	19.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.88	0.71	-3.95	19	70	2009-01-15 18:05:59	2008-06-30 13:46:07	4	1	70	0	38	74	23	137.40	39	97.41	CHANGED	M.+l.Gssusosusuutsp..ppuGu.uuFulss...ssssspst..usuustuhuulD..ALLALQuh...-D...shER.R+RuVpRGcshLDsLD-LKhuLLsGplspusls+Ltssstph+suouDPtL-ulLsEIELRscVELAKhup...s	.................M.+l.Gssusssssuspss...ctsuu..uuFuh..ss...ssssspsp...usuustusuulD..ALLALQul.....-D....ssER..R+RuVpRGcshLDsLD-LKhuLLuGplssspLtcLtssltph+ssouDPtL-ulLsEIELRscVELAKhstt..	0	15	24	28
+10601	PF10769	DUF2594		Protein of unknown function (DUF2594)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Enterobacteriaceae.	23.70	23.70	72.10	72.00	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.37	0.72	-3.90	6	530	2009-01-15 18:05:59	2008-06-30 13:52:11	4	1	527	0	36	97	0	73.80	83	99.99	CHANGED	MSssDFoTuussppLAsEVoCLKAhLTLlLKAIGQADAG+VIlNMER.IAplEDspQAtVFsNTlpQIKpuYRQ	...MSTPDFSTAENNQELANEVoCLKAMLTLMLQAMGQADAGRVhLKMEKQlAhIEDEsQAAVFSpTVKQIKQAYRQ..	0	1	8	21
+10603	PF10771	DUF2582		Protein of unknown function (DUF2582)	Mistry J, Coggill P	anon	PRODOM_PD055730	Family	This family is conserved in bacteria and archaea. The function is not known.	24.20	24.20	24.20	24.20	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.30	0.72	-4.12	23	279	2009-01-15 18:05:59	2008-06-30 14:03:51	4	3	136	4	47	185	10	65.40	34	76.42	CHANGED	Mccph............IGtsAGclWphLs-..tschShspLp...+csuL.scc-lthAlGWLAREsKIthc.....cpstplhlpL	....................M.+pp........lGhsAGcVWphLsp..pt.p.hohppLp...+tspL..scc-lhhAlGWLuREsKI.php.....phpt.hhl.............	0	13	36	44
+10604	PF10772	DUF2597		Protein of unknown function (DUF2597)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	113.10	113.00	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.51	0.71	-4.25	29	118	2009-01-15 18:05:59	2008-06-30 14:05:21	4	1	113	0	20	81	2	133.10	52	88.93	CHANGED	psFDhslhshhVHVcssoloITDsSssspTRGVPDGaVDGDVuA-GElELDspsFphlspAA+sAGSaRulcshDhhFYApsGp.-EhKVEsFGsKlhloDlLsIDPcGGscss+KlKa.VTSPDFV+INGVPYL	..................hsFDshlsu.hlHlEphoLsITDNSAsAQTRGVPDGaVDGDVuA-GElElsopsFphLsstA+sAGSWRul.PhDhlFYApsGs.-EhKVEsFGsKlplSslLsIDP.cGGutsT+KlKahVTSPDFV+INGVPYL......	0	3	11	13
+10606	PF10774	DUF4226	BssS;	Domain of unknown function (DUF4226)	Pollington J, Finn RD, Bateman A	anon	PRODOM	Domain	This family of mycobacterial proteins are uncharacterised.	22.00	22.00	22.20	22.40	21.30	21.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.40	0.71	-4.03	9	168	2009-01-15 18:05:59	2008-06-30 14:13:42	4	4	64	0	19	82	0	109.40	45	37.19	CHANGED	cpsGsuA-AlpstcsALAcQpussu-sDtplssAlhsAHssss-Gtc+LstltpEI-sAVsppus.uLDTPAGAR-Fp+FLluKh+-ItpVVssAshpspuKuslhsuLsuhY	..........ptGsustslpsccuuLAppp..ussAEsDcplsssLtsAHsuhs-GtRRLcAIuAEI-sA...Vscpss.huLDTPAGAR-Fp+FLhuKt+-IppVVAsAst-upu+uAllcuLsupY........................	0	3	8	16
+10607	PF10775	ATP_sub_h		ATP synthase complex subunit h	Pollington J, Finn RD	anon	PRODOM	Family	Subunit h is a component of the yeast mitochondrial F1-F0 ATP synthase. It is essential for the correct assembly and functioning of this enzyme. Subunit h occupies a central place in the peripheral stalk between the F1 sector and the membrane [1].	25.00	25.00	39.30	38.50	23.90	17.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-9.12	0.72	-4.25	18	131	2009-01-15 18:05:59	2008-06-30 14:18:51	4	3	129	0	99	122	0	69.20	44	51.92	CHANGED	RsFSo..sstpt-llQDLYL+ELKuaKssPlsssDucGpV+pashPssPssPp....s-l..uu-.LcuYc.spsVE	..........RsFhs..ssppsDhVQDLYL+ELKAYKssP..h.....pt..sDA-G.....pVppFshPpsPpuPE....s-L...As-.LKuYEspsVE...............	0	27	55	84
+10608	PF10776	DUF2600		Protein of unknown function (DUF2600)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins. Some members in the family are annotated as YtpB however currently no function is known.	25.00	25.00	148.20	112.40	19.60	19.10	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.03	0.70	-5.60	29	211	2009-09-11 11:05:58	2008-06-30 14:30:12	4	2	203	0	50	164	0	326.10	55	92.33	CHANGED	PlVH+ELuhW+c+Ah+IPscEL+pQAlASIccKTFHCEGGuIhALLAs-+p--sIRFIVAYQTISDYLDNLCDRSTSLDPpDFtsLHpSMhtALoscsE..susYYRaR--Q-DGGYLc-LVcTCQcVLpchcpY-tItPhLpELAsYYCDLQlHKHVc.-.ERcPRLpsWF-ta+csLPt.MoWaEFSACuGSTLGIFCLVAYAacs-Lp-c-stKIRpuYFPYlQGLHILLDYFIDQEEDRhGGDLNFCsYYpscpthh-RhpHFlEcA-cplusLPHscFHRLIsRGLLGlYLSDpKVsuQ+ph++hA++llKhGGhsSpFFYhNG+hYRK	.........PlVH+ELshW+c+AhpIPssEL+sQAlASIccKTFHCEGGuILA.L.L.us.-c.+ccsI+FIVAYQTISDYLDNLCDRSTSLDPsDFttLHpSMh.ALoPcs-.....suNYY+aRc-QDDGGYLc-LVcTCQcVLpchp+Y-tItPhLcELAsYYCDLQlHKHVchE.EREPRLpsWF-tH+c.slP.-...MsWaEFSAC.uGSTLGIFC.LVAYAa.c.s-Lp-EchtKIRpuYFPYlQGLHILLDYFIDQEEDRhGGDLNFCoYYcscpthl-RhcHFlEcA-cslscLPHucFHRLIsRGLLGlYLSDpKVus.Q+.ph++hAR+llK.h.G.GhsShFFYhNG+hYRK..................	0	23	39	42
+10609	PF10777	YlaC		Inner membrane protein YlaC	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Domain	Members of this family include proteins annotated as inner membrane protein YlaC in E. coli and Salmonella. The function of this family is unknown.	20.30	20.30	21.20	21.00	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.03	0.71	-4.67	8	536	2009-01-15 18:05:59	2008-06-30 16:19:27	4	2	531	0	39	134	3	153.20	75	97.48	CHANGED	MsEIpRLLscsI-RlNpcEKRDN+PRFShsFIRcHPhLFlAMasualAsLsVMhhophh.hsSlhhhsVLFllhsAhhhhDlpPpYRaEDIDVLDLRVCYNGEWYsTRtVssphI-cILssPpVssshKsplcKhlssKGElsFYDVaoLAhspps	..............................MTEIQRLLoETI-sLNsREKR.DNKPRFSISFIRKHPGLF.IuMYVAaFATLAVMLQSETL.oGSVWLLVVLFILhNGFFFFDVhP...RYRYEDIDVLDFRVCYNGEWYNTRFVPssLlEsILNSPcVuDsHKpQLQKMIsR.KGELSFYDIFTLARAEuo......	1	1	7	23
+10610	PF10778	DehI		Halocarboxylic acid dehydrogenase DehI	Pollington J, Finn RD	anon	PRODOM	Family	Haloacid dehalogenases catalyse the removal of halides from organic haloacids. DehI can process both L- and D-substrates.  A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuration of either L- or D-substrates in contrast to D-only enzymes [1].	21.50	21.50	21.50	23.20	21.30	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.63	0.71	-4.71	12	73	2009-01-15 18:05:59	2008-06-30 16:26:33	4	4	42	4	8	69	11	122.20	37	74.63	CHANGED	WVuhsh+shApaspFlstuWpthcsthtTRhhEcuA-plRtto...lhs..hshss.sttLhutGas.t-lccl+ssl-hFsYGNPKYLllhoAhpE.uhptRshuGts...hsut.ssphPhGhsp.h...hpLl-.ccAspcspplLpDItcshhphtsuSDa	..aVuFshRs.hupaPsFlstAWtsh+PslpTRaAEcuADtlRhpS...lssu...sshss..Ts.+.LhthGas-p-Iccl+ssLDlhNaGNPKhLl......................................................................................................................................	0	4	7	8
+10611	PF10779	XhlA		Haemolysin XhlA	Pollington J, Finn RD	anon	PRODOM	Family	XhlA is a cell-surface associated haemolysin that lyses the two most prevalent types of insect immune cells (granulocytes and plasmatocytes) as well as rabbit and horse erythrocytes [1]. This family has had DUF1267, Pfam:PF06895, merged into it.	34.70	34.70	35.30	35.10	34.60	34.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.44	0.72	-4.06	47	409	2009-01-15 18:05:59	2008-06-30 16:30:38	4	1	232	0	46	250	1	70.50	30	88.24	CHANGED	hpclppclsplcsc.cp.......htpthpshEhtsthp-ps..........ltslscpLpcIppNppWlhR...hllGullsu....llshlhK	...........p-lhpclsplcschcp.......htpclcsLEpp...sstp-pc..........ItslscpLc+IssNspWllR....llluullsu....llshlhK..............	0	21	36	40
+10612	PF10780	MRP_L53		39S ribosomal protein L53/MRP-L53	Pollington J, Finn RD	anon	PRODOM	Family	MRP-L53 is also known as Mrp144. It is part of the 39S ribosome [1].	24.80	24.80	25.00	25.00	24.00	24.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.43	0.72	-3.99	20	175	2009-01-15 18:05:59	2008-06-30 16:32:23	4	2	165	0	124	165	0	51.80	33	44.15	CHANGED	FNPFutsu+sARLFLuhl.....ssos+stuhplpsclLscso..sppPplcVtFKDG	........FsPFstpu.+ssRhFLshl.......sst+sptoslsspllscss...pptPplpVtFtDG....	0	23	57	95
+10613	PF10781	DSRB		Dextransucrase DSRB	Pollington J, Finn RD	anon	PRODOM	Family	DSRB is a novel dextransucrase which produces a dextran different from the typical dextran, as it contains (1-6) and (1-2) linkages, when this strain is grown in the presence of sucrose [1].	25.00	25.00	26.50	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-8.96	0.72	-4.48	5	506	2009-01-15 18:05:59	2008-06-30 16:43:54	4	2	504	0	33	111	1	61.60	90	97.22	CHANGED	MKVNDRVTVKTDGGPRREGVILAVEEFSEGVMYLVSL-DYPAGIWFFNElDSpDGTFVEhts	.....MKVNDRVTVKTDGGPRRPGVVLAVEEFSEGTMYLVSLEDYPLGIWFFNEuGHQDGIFVEKA.E....	0	1	8	20
+10614	PF10782	DUF2602		Protein of unknown function (DUF2602)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.20	26.20	23.60	22.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.18	0.72	-4.13	14	323	2009-01-15 18:05:59	2008-06-30 17:10:47	4	1	304	0	25	89	0	57.20	57	82.95	CHANGED	hs++phhtcls-L.spYCpuChlKcHhRKp.GKsaAHpFCIppCTlGcclKphGppLp	............scpphlscIsDLhsTYCppC.lKp+hRKhpGKTtAHpFCIscColGKpIKQlGspLp.....	0	4	10	17
+10615	PF10783	DUF2599		Protein of unknown function (DUF2599)	Mistry J, Coggill P	anon	PRODOM_PD414589	Family	This family is conserved in Actinobacteria. The function is not known.	25.00	25.00	25.70	28.70	23.70	24.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.40	0.72	-3.34	12	152	2009-01-15 18:05:59	2008-07-01 12:49:54	4	3	148	0	39	108	0	94.80	43	49.17	CHANGED	lD+spWspass......h.oLpVhPTpsGRpsstp.s.....tstAWsEllsLuP-............AsssGMRtQFlCHap..........aAchhtPuKsSWNLEPWRPsVssp-hlApGCNPG	...................l-pspWsphss......h.SLpVhPops.G.R..ss.sp.p.s.......h-sAWsEVluhsP...c............AsosGMRsQFlCHap..........aAc..........ssKsSWNLEPa.RPsVsss-hlAsuCNPG................	0	6	22	31
+10616	PF10784	Plasmid_stab_B		Plasmid stability protein	Mistry J, Coggill P	anon	PRODOM_PD189613	Family	This family is conserved in the Enterobacteriales. It is a putative plasmid stability protein in that it is expressed from the operon involved in stability, but its actual function has not yet been characterised.	25.00	25.00	25.90	25.30	23.70	23.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.15	0.72	-4.36	11	396	2009-09-11 13:35:50	2008-07-01 12:52:36	4	2	221	2	9	189	0	68.40	37	59.10	CHANGED	R+hohYLpP-t.puDphApshl-olspptRGchhRsAhlsGhALaplDPRLPhLlushhscphossplspll	.........R+hohYL+Pst.ps-t.Asthl-ols.ptRuch.RsAhluGhALhphDPR...hshlLushhs--hsssslsph..................	0	0	2	4
+10617	PF10785	NADH-u_ox-rdase		NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit	Mistry J, Coggill P	anon	PRODOM_PD104546	Domain	This family is the N-terminal domain of NADH-ubiquinone oxidoreductase 21 kDa subunits from fungi, lower metazoa and plants.	25.00	25.00	30.40	29.20	23.40	21.00	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.82	0.72	-3.74	35	183	2009-01-15 18:05:59	2008-07-01 13:39:47	4	2	163	0	125	165	0	84.40	35	51.07	CHANGED	hpocYPlI.....DsDP...ahpRVlsYhRsSDYshhuussuuhPshhahhEphsPstst.h......ssshRhushlGhhGGFhhsYpRSstRFhGapE	.......................hpscYPlI.....DscP............pap+Vlu.hRsuDYshhushuususshhahhtphssspht................usuMphuuhlGhhGGFhhsYQpSshRhhGapE...............	0	43	80	110
+10618	PF10786	G6PD_bact		Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)	Mistry J, Coggill P	anon	PRODOM_PD110134	Family	This family is conserved in Firmicutes and Proteobacteria. Several members are annotated as being glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49) but this could not be confirmed.	25.00	25.00	25.70	25.40	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.66	0.70	-4.91	9	269	2009-01-15 18:05:59	2008-07-01 13:44:42	4	1	265	0	18	153	0	202.90	45	98.10	CHANGED	hLospsh-lFshPhFpFtQlK.KasPE-IspIKA-YKtpWQhWKplp.pVupQLss..sFAcPHIEpWsNGWplRuHFaAhY+hph.pspuAhluVlLN++pLQVhL.appY+uD+pQholppYNphLspl....Dphchuca.lWctsEpEasDahslsph.....pppshshcsc-chaplGK.h.+sc.sh.DhtcFIhcTIccLhPLYE+h+	.......LTtpshsLFshPhFpFtQLK.pasP-cIspIKs-...YKppWppWKtl..pVAttLss...sFAcPHIESWsNGWpl.RuHFaAha+hEppp..spsAhL...ulLLN++pLpV.L.appYKu-cpthslspYNp.hLsph....cshchtsa.lWcts.EpEasDahslpph.....pppphphcsscchFpIGKhh.ps-.phpchtphhspslp-LhPLYpth................................................................................	0	3	7	12
+10619	PF10787	YfmQ		Uncharacterised protein from bacillus cereus group	Mistry J, Coggill P	anon	PRODOM_PD089522	Family	This family is conserved in the Bacillus cereus group. Several members are called YfmQ but the function is not known.	20.90	20.90	20.90	36.20	20.80	19.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.78	0.71	-4.85	7	191	2009-01-15 18:05:59	2008-07-01 14:15:02	4	1	116	0	14	119	1	139.80	65	98.44	CHANGED	MThWhIlhLVlFuhhKllVoslPouVVE.lluKFElHscLp--ssolohsG+pLEGppKpclIppFNEAlFL-+YYh.PusE.........GTPLlIpTKpGK+-VphalYpYDDHlDVVKQY....KKKllAYpLRScsLQsss.h.hstshh	.........MTTWFIVhLhlFGAhKllVSShPsoVlESIISKFEhH.KL-EE.NsoloIcGpNlEGEpK.plIH-FNEALFLD+aYhPPHsE.........GTPllIcsK+GKK-lpF.lYSaEE.HVDVlKQY....KKKVVAYpLRSKsLQsps.hhlotDh.A........	0	3	8	9
+10620	PF10788	DUF2603		Protein of unknown function (DUF2603)	Mistry J, Coggill P	anon	PRODOM_PD098479	Family	This family is conserved in Epsilon-proteobacteria. The function is not known.	25.00	25.00	74.70	74.50	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.74	0.71	-4.41	12	175	2009-01-15 18:05:59	2008-07-01 14:22:06	4	1	173	0	16	72	0	135.20	56	83.07	CHANGED	lschupsLGlpccp.pTlhchhp..psNEhhLpLcsGshspsEPWFhlDEpsph+sllohp.lptLlpslKpup+ENFcL+LEKsIhQphPlDFsDVWsVAh-EI++httpst.....sIslcpLlccIK+EHPNLFhshc	......................IDEhSpsLGhcKc-.RsIFKhKpops-NE+sLh..LEsGSFDo.sEPWFlhDENDclHTLlSlpSLpNILEsLKpuQKENFELRLEKAIaQQIPlDFsDVWpVAMDEIKppAQpss.c..lsIDL-KLlpcIK+EHPNLFVDMp.	0	4	13	16
+10621	PF10789	Phage_RpbA		Phage RNA polymerase binding, RpbA	Finn RD	anon	PRODOM	Family	Upon infection the RpbA encode phage protein binds to the ADP-ribosylated core RNA polymerase and modulates function to preferentially bind T4 promoters.\	     This is a non-essential protein to the phage life cycle.	21.00	21.00	21.10	22.50	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.43	0.72	-4.20	8	36	2009-01-15 18:05:59	2008-07-01 14:49:10	4	1	35	0	1	35	0	103.20	35	85.48	CHANGED	uDIpsp.hpo-us.cspNKIRKAWVLphsDsptcpLQul.Qc..sRFtLYupIDc-Vp-pWIcLMR++ps-uLssGuKhVhsh.GpchLtcpYphDsDEhLIsAAplV....huch	........tDIQsK.hpo-us.pspN+IRKAWVLphs.-sstctlQsh.pp..sRatlYptIDc-VpcpWI-LM+++ps-uLssGAKhlhsp.stchLEcpYphssDEhLl.AuplVhtp.h...........................	1	0	0	1
+10622	PF10790	DUF2604		Protein of Unknown function (DUF2604)	Finn RD	anon	PRODOM	Family	Family of bacterial proteins with undetermined function.	20.90	20.90	21.20	144.30	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.23	0.72	-3.84	3	5	2009-01-15 18:05:59	2008-07-01 15:11:21	4	1	5	0	3	5	0	76.00	69	56.89	CHANGED	VVVNGQPVsVEANVNAPLHsVlAKALEpSGNVGQPsENWELKDEuGsVLDlsKKVEDaGFTNGVKLFLSLKAGVAG	VVVNGQPTQVEANPNQPLHVVRAKALENTQNVAQPAENWEFKDEAGsLLDlDKKVGDFGFANsVTLFLSLKAGVAG	0	0	2	3
+10623	PF10791	F1F0-ATPsyn_F		Mitochondrial F1-F0 ATP synthase subunit F of fungi	Mistry J, Coggill P	anon	PRODOM_PD068018	Family	The membrane bound F1-FO-type H+ ATP synthase of mitochondria catalyses the terminal step in oxidative respiration converting the generation of the electrochemical gradient into ATP for cellular biosynthesis. The general structure and the core subunits of the enzyme are highly conserved in both prokaryotic and eukaryotic organisms.	23.00	23.00	23.00	24.40	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.12	0.72	-3.75	14	131	2009-01-15 18:05:59	2008-07-01 15:39:51	4	1	128	0	99	115	0	92.00	53	70.67	CHANGED	Mhh.....+RuLSTLI............P.PKlsosts.luuussAtRhtpVVsFYcpLPpGPAPthpss..uh.lu+YpAKYF..pGcNASG+PllHhlhullhhGYuh-YaFHL+	............................M.alhRRuLSTL.I......P.PKlA....Ssps.lGuAssA......tRMpcVVsFYc+LP+GsAPt..sKssGh...lGRYpA+YF...G+NASup...........PllHhlhullhlGYoh-YYFHLR............................	0	26	55	84
+10624	PF10792	DUF2605		Protein of unknown function (DUF2605)	Mistry J, Coggill P	anon	PRODOM_PD070476 	Family	This family is conserved in Cyanobacteria. The function is not known.	25.00	25.00	46.40	46.30	18.70	18.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.33	0.72	-4.32	17	56	2009-09-11 15:07:39	2008-07-01 15:50:20	4	1	54	0	21	59	22	96.20	46	90.09	CHANGED	ps.ststLLcslL-sLLcDFpaWFpRuccLLpsps.shhstc-ppsLhpRlcpupptltus+uLhpAostthuVsMpsMsPWHpLVsEsWtlAsRhppt	..sp.sps-LL+olL-PLL-DFpaWFsRucpLLEs-plsFhospEQpcLLsRV+pAQpEVpss+hLFpATstQsGl-hpshhPWHpLVsECWplutRaRp.h..	0	2	14	19
+10625	PF10793	Gloverin		Gloverin-like protein 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins are Gloverin-like. Gloverin is a 13.8kDa inducible antibacterial insect protein which inhibits the synthesis of vital outer membrane proteins leading to a permeable outer membrane. Gloverin contains a large number of glycine residues [1].	25.00	25.00	35.90	63.40	23.70	16.70	hmmbuild  --amino -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.93	0.71	-4.58	5	27	2009-01-15 18:05:59	2008-07-01 15:51:29	4	2	12	0	7	27	0	137.10	61	91.41	CHANGED	QVShPPGYAc+YPpYhKaSKpsRHPRD....VTWDKplG.sGKVFGTLGQNDDGLFGKGGYp+-FFNDHRGKLTGQAYGTRVLGPuGDSTNaGGRLDWANKNApAALDVsKQIGGRoGloASGSGVWcLDKNT+LSAGGsLSKsFGHsRPDVGlQApIpHDW	....................t..p.Ys.....S+..RHPRD....lTW-+phG.sGKVFGTLGpsDpGLFGKuGYppphFNDcRG+LpGQAYGoRVLGPsGDSTsaGGRLDW..uNcNApAAlDls+QIGGpoGhoAoGSGVWsLDKNT+LSAGGslSK.pFGHp+PDVGlQAphpH-a......	0	6	7	7
+10626	PF10794	DUF2606		Protein of unknown function (DUF2606)	Finn RD	anon	PRODOM	Family	Family of bacterial proteins with unknown function. These proteins have been classified as membrane proteins	25.00	25.00	25.40	99.40	24.80	23.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.49	0.71	-4.72	4	45	2012-10-02 19:08:27	2008-07-01 15:55:09	4	2	45	0	2	34	0	112.50	51	95.78	CHANGED	Ma.hIhp.G.lNKYsphlah....LsIlhhsuhhsss-pshpKsl.PVThHVcst-tpPlcshplhlhK..-ps.pPSpEIG..IGKTDccGclhW+ssRKGcYhVhLspsEsp.s....lhpD+cspplI.Isl	.............................hhsushuss-pphuKsl.sVThHVcNKEKpPlKsFEIhLMK..DpsPpPS+EIGISIGKTDcEGKlIW+ssRcGcYIVhLPNsETphl....hlNDRctsclIsIs.h	0	1	1	1
+10627	PF10795	DUF2607		Protein of unknown function (DUF2607)	Mistry J, Coggill P	anon	PRODOM_PD067168	Family	This family is conserved in Gammaproteobacteria. The function is not known.	20.50	20.50	20.90	20.60	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.51	0.72	-4.17	7	95	2009-01-15 18:05:59	2008-07-01 15:59:13	4	1	95	0	10	53	4	93.30	56	99.24	CHANGED	M..athpth.pph+Rpsl...huVsLhlhhshAsltHplDlsPEHHspHHCQLFuuspHGlsp.....u.P.l.sPsappt..pslhtpshphtplh..hhARuPP.hhu	...........................p+hsl..MLSVVLuLWFNVAVIDHQLD.LHPEHHLQHDCQLFASAAH...GLKT......SQWlL...P...SWRQNPP..QARVEQPIQ.RsQVLa.SYFARSPP....AA.	1	1	2	6
+10628	PF10796	Anti-adapt_IraP		Sigma-S stabilisation anti-adaptor protein 	Mistry J, Coggill P	anon	PRODOM_PD028886	Family	This family is conserved in Enterobacteriaceae. It is one of a series of proteins, expressed by these bacteria in response to stress, that help to regulate Sigma-S, the stationary phase sigma factor of Escherichia coli and Salmonella. IraP is essential for Sigma-S stabilisation in some but not all starvation conditions [1].	21.80	21.80	22.10	22.60	20.80	21.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.87	0.72	-3.60	8	516	2009-01-15 18:05:59	2008-07-02 10:59:42	4	2	476	0	39	130	0	84.70	75	97.83	CHANGED	MKNLIucLLsKLAcKEtEuKpLsAQVEALEllloAlLpsh.csss.pcLIcsVEpAlssApssssss.+.DoElLpp.lp+LLphsps	......MKNLIAELLhKLAQKEEESKELsAQVEALEIIVTAMLRNM...AQN-QQcLI-QVEGALhcVKPD..A..SlPDc.DTELLRsYVKKLL+HPRp...........................	0	1	4	25
+10629	PF10797	YhfT		Protein of unknown function	Mistry J, Coggill P	anon	PRODOM_PD140382	Family	This family is conserved in Firmicutes and Proteobacteria. The function is not known but several members are annotated as being homologues of E coli YhfT, a protein thought to be involved in fatty acid oxidation.	25.00	25.00	79.40	79.30	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.30	0.70	-5.63	13	324	2009-01-15 18:05:59	2008-07-03 11:56:38	4	2	316	0	28	135	1	424.10	79	98.09	CHANGED	lcIlLlAllGuhuAlLANpulAVFpDGlRPIlPEhlEGpMsR+ELuusuFALShGhVhGFGIPhoLusuIllsH.lhLsTDIIGlhssssh....lAullGulaGlhllhuLpsVlslFstLPVNFlsuLuplGsPVlsAFAlFPAlAluYQFGhKpGllshllshluRllls...+at.h.hu.s.....lsLsPEGIulllGMlhLlhaAh+c+hs-css.........ushsolFs-RlpRIpKNhhhLulsGAL..lAAsuuhtIlAGsslSltLLAcu............tlspAAlAshsRulGFlPLIATTAlATGVYGssGhTFVFssG.hluPNPhlAuILGAllIhlEVhLLssIu+aL-+aPulRsuu-NIRTAMspllElALLIGGshAupphuPshGFhllsulYlLNEshGRPll+hAsGPVAAIlsGIlhNlLhllGLF	.....IQIIVVACLTGMTSLLAHRSAAVFHDGIRPILPQLIEGYMNRREAGSIAFGLSIGFVASVGISFTLKTGLLNAWLLFLPTDILGVLAINSL...............MAFGLGAIWGVLILTCLLPVNQLLTALPVDVLGSLGELSSPVVSAFALFPLVAIFYQFGWKQSLlAAVVVLMTRVVVV...RY............FPHLNPESIEIFIGMVMLLGIAITHDLRHRDEN.................DIDASGLSVFEERTSRIIKNLPYIAIVGAL..IA..AVASMKIFAGSEVSI.FTLEKAYSAGVTPEQSQTLINQAALAEFMRGLGFVPLIATTALATGVYAVAGFTFVYAVG.YLSPNPMV.....AAVLGAVVISAEVLLLRSIGKWLGRYPSVRNASDNIRNAMNMLMEVALLVGSIFAAIKMAG......YT......G.....FSIAVAIYFLNESLGRPVQKMAAPVVAVMITGILLNVLYWLGLF...........	0	8	13	22
+10630	PF10798	YmgB		Biofilm development protein YmgB/AriR	Pollington J, Finn RD	anon	PRODOM	Family	YmgB is part of the three gene cluster ymgABC which has a role in biofilm development and stability. YmgB represses biofilm formation in rich medium containing glucose, decreases cellular motility and also protects the cell from acid which indicates that YmgB has an important function in acid-resistance [1]. YmgB binds as a dimer to genes which are important for biofilm formation via a ligand. Due to its important function in acid resistance it is also known as AriR (regulator of acid resistance influenced by indole) [1].	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.79	0.72	-4.16	6	700	2009-09-11 05:26:58	2008-07-28 14:30:18	3	1	416	2	58	197	0	55.90	43	68.79	CHANGED	tpEuulluslVpplLtossaVoNKsIIhpLI+pLETpsDlVptDlhRpsLElVVtpTsDD..I	.................EptsLGphVspLhpuGcslsNKsIIhpLIppLEoppDhhphDlhRpsLEhVl..TsDDh....................	0	2	6	42
+10631	PF10799	YliH		Biofilm formation protein (YliH/bssR)	Pollington J, Finn RD	anon	PRODOM	Family	YliH is induced in biofilms and is involved in repression of motility in the biofilms [1]. YliH is also known as bssR (regulator of biofilm through signal secreton).	20.40	20.40	20.50	119.10	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.59	0.71	-4.44	4	440	2009-01-15 18:05:59	2008-07-28 14:32:18	3	1	439	0	14	59	1	124.30	86	99.55	CHANGED	MsVDRL+pDLLNKLINARIDLAAYLQLRKAKGYMSVSESDHLRDNhFELsREh+s+A.RLp.HlDtEEhssLR+At-ALAsAAVCLMSGHHDCPTaIAVNADKLENCLToLTLsIpsLpcHuPLpps	...MhVDR.RhDLLN+LIsARlDLAAYlQLRKAKGYMSVSESNHLRDNFFKLNRELHDKSLRLNLHLDQEEWSALHHAEEALATAAVCLMSGHHDCPTVITVNADKLENCLMSLTLSIQSLQKHAMLEKA.....	1	1	1	7
+10632	PF10800	DUF2528		Protein of unknown function (DUF2528) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function. Some of the sequences are annotated as ea10 however the function of this protein is unknown.	22.00	22.00	22.10	31.80	20.00	21.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.29	0.72	-3.63	4	191	2009-01-15 18:05:59	2008-07-28 14:32:53	3	1	157	0	4	72	0	105.50	89	89.24	CHANGED	uacIlV-lDHslLTEEKLsELspFWS-u-hclE+HGs.LpAhLphhAs+hhuhslpp......lSscssaN..ust.EGaPshDGSpGlRls-hDph..F-uDDhcVhtl	.....KASIEIE.IDHDVMTEEKLHQINNFWSDSEYRLN.KHGSV.LN....AVLIMLAQHALL.IAIS..SDLN.....AYGVVCEFDWND.GNGQEGWPPMD....GSEGIRITDIDTSGIFDSDDMTIKA.A.......	1	0	1	2
+10633	PF10801	DUF2537		Protein of unknown function (DUF2537)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.30	20.30	21.10	31.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.04	0.72	-3.88	8	113	2009-01-15 18:05:59	2008-07-28 15:02:40	3	1	112	0	28	72	1	83.60	58	76.69	CHANGED	TPWATGLTVAuFVAAVluVAlVVLolGLhRVHPLLAVGLNlVAVGGLAPTlWGWR+TPVhRWFVLGAAVGVsuAWlALLllAh.G	...sPWATGLsVAuFVAA...VlAVAVVVLSlGLl.R.VHP......LLA......VuLNl.VAVuGLAPTLWuWRRsPVLRWFVLGAAVGVAuuW...lALLsls.............	2	7	20	25
+10634	PF10802	DUF2540		Protein of unknown function (DUF2540)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Methanococcus.	25.00	25.00	82.90	82.80	23.90	19.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.21	0.72	-4.31	12	26	2009-01-15 18:05:59	2008-07-28 15:06:32	3	1	13	1	9	21	0	75.30	39	84.61	CHANGED	phtLhcplDs+slRYaLHKL-sl.splss-lLtcuhcscKpa+poloLo-pEccIlcKYG.KuTNhLlNahIlpppp	.pFtLh+slDsRslRYhLHKlEsl.cpIss-l..Lt+AhcscKpa++olTLo-cEccIlcKaG.KuTNlLlNhhIlppc....	0	1	3	6
+10635	PF10803	GerPB	DUF2539;	Spore germination GerPB	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Family	Members of this family are required for formation of functionally normal spores. They may be involved in the establishment of spore coat structure or permeability [1].	25.50	25.50	25.60	50.80	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.56	0.72	-4.21	7	135	2009-01-15 18:05:59	2008-07-28 15:07:18	3	1	134	0	19	64	0	52.40	69	75.89	CHANGED	MNFYlpQoIpINhlRltuloNSSVhQIGSAGSIKsLSpLYNTGuasEPAP.ssus	...MNFYlNQSIhINpl+I-SITsSSVFQIGTAGSIKuLSKFSNTGGFTEPhRPLpAK...	0	4	11	13
+10636	PF10804	DUF2538		Protein of unknown function (DUF2538) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	20.50	20.50	23.80	23.50	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.02	0.71	-4.34	3	217	2009-01-15 18:05:59	2008-07-28 15:07:59	3	1	215	2	10	43	0	153.40	91	99.52	CHANGED	MSRKTYEKlANINGMFNVLEQQIIHSKDMALFRSEFFYVNHEHRENYEALLIYYK-SslNPIVDGACYILALPEIFNKVDVFESELPFSWVYDENGITETMKSISVPLQYLIAAALEVTDVNLFKPSGFTMGMNNWNIAQMRIFWQYTAIVRKEAL	....MSRKTYEKIANINGMFNMLEQQIIHSQDMAHFRSEFFYVNHEHRENYEALLIYYKNSIDNPIVDGACYILALPEIFNSVDVFESELPFSWVYDENGITETMKSLSIPLQYLVAAALEVTDVNIFKPSG...FTMGMNNWNIAQMRIFWQYTAIIRKEAL..............................................	1	3	4	10
+10637	PF10805	DUF2730		Protein of unknown function (DUF2730)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.24	0.72	-4.30	11	133	2009-09-10 19:13:11	2008-07-28 15:08:36	3	1	124	0	31	115	5	98.70	21	91.33	CHANGED	hh.hlpspWsl.lhulhshssshhhhhhsppYA++c-ltpL.......-pRLsphEs+lcsLPTpp-VpcLclplscl+G-hKshssslpsloHQscLLLEpcL..pcc	............................................................t.ash.lhshh...hsshhhhhh.pp.p.a.sp.ccchpp...............L..............................cpRlsp.lEsclpslPspp-lpcLplplsplcG-l+slsspl....psl....s+..pLLlEptl.....pt..................................	0	10	22	26
+10638	PF10806	DUF2731		Protein of unknown function (DUF2731)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	21.40	21.40	21.40	22.30	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.71	0.71	-3.87	11	76	2009-01-15 18:05:59	2008-07-28 15:10:58	3	4	74	0	52	74	0	94.50	29	29.59	CHANGED	hpVPsPlKplFDsFPLpsY..tslsppcsus.pslpp+pahF..............sssssp.sssssFpLGVaNVhphptst.....shLsoDPhuLhspLhLC+KNsLtLPo.........tsss...................spsssslhhLShhAusDppLPILlE	..hsVPsPlK+lFDpFPLhTY..ss.sttspshttp..hpp.+hasF..............ts.t.t.t.....................................................................................................................................................................	0	7	22	41
+10639	PF10807	DUF2541		Protein of unknown function (DUF2541)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. All proteins are annotated as YaaI precursor however currently no function is known.	21.90	21.90	24.00	23.70	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-4.39	2	436	2009-01-15 18:05:59	2008-07-28 15:11:09	3	1	433	0	6	84	0	132.60	88	99.68	CHANGED	M+SlhplSVGLlhGluh.osAtANDHKILGVIAMPRNETNDLsLplPVCRlVKRIQLoAD+GDlpLSGAoVYFKsuRuASpoLNVPuuIKEGpTTGWININSDNDsKRCVpKIsFSGHTVpSSDMApLKlIGDD	.............MKSVhTISASLA...I.S.LML.CCTAQANDHKILGVIAMPRNETNDLALKLPVCRIVKR...IQLSADHGDLQLSGASVYFKAARSASQSLNIPSEIKEGQTTDWININSDNDNKRCVSKITFSGHTVNSS.DMATLKIIGDD........	0	1	2	4
+10640	PF10808	DUF2542		Protein of unknown function (DUF2542) 	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.	25.00	25.00	57.30	57.20	22.20	22.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.75	0.72	-3.71	3	411	2009-01-15 18:05:59	2008-07-28 15:46:52	3	1	410	0	6	41	0	78.50	81	99.60	CHANGED	MDVQTIFVVlAFLLlPLFCFREAWKGWRoGAVDKlVKNAREPVYVYRAcsPlLYWSYlsLYlGhGlLolGMIIYLLFYR	MDVQQFFVVAVFFLIPIFCFREAWKGWRAGAIDKRVKNAPEPVYVWRAKNPGLFFAYMVAYIGFGILSIGMIVYLIFYR.	0	1	1	4
+10641	PF10809	DUF2732		Protein of unknown function (DUF2732)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	25.40	25.30	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.57	0.72	-4.43	8	350	2009-01-15 18:05:59	2008-07-28 15:49:26	3	1	279	0	29	161	1	73.20	45	96.25	CHANGED	M+NschtoTpous--shLspLLs-ARhEERKsRAhAlShRL-ALAlHIsp+phousEAAELLR+EAs+aEsESQ.ElH	......................................t....hslLLspARhEERpspApthuuRLDuLAsHITpcpLs+VEhsELLRppAEphpNput.-........	0	0	7	21
+10642	PF10810	DUF2545		Protein of unknown function (DUF2545)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function is restricted to Enterobacteriaceae. The sequence is highly conserved.	25.00	25.00	68.60	68.50	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.95	0.72	-3.58	2	416	2009-01-15 18:05:59	2008-07-28 15:50:10	3	1	412	0	5	40	0	79.40	86	99.91	CHANGED	MIYLWhFLAlsIlsVSGYIGQVhshhSAlSSFhGMVILAALIYhhshWLpsGs-lVoGlhhFLAPACGLhIRFMVGYG+R	....MIYLWMFLALCIVCVSGYIGQVLNsVSAVSSFFGMVILAALIYYFTMWLTGGNELVTGIFMFLAPACGLMIRFMVGYGRR..	0	1	1	3
+10643	PF10811	DUF2532		Protein of unknown function (DUF2532)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	280.50	280.30	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.04	0.71	-4.42	11	41	2009-01-15 18:05:59	2008-07-28 15:51:57	3	1	41	0	6	23	0	158.00	85	95.55	CHANGED	KLIhCFLILVSAVKVNADFNsIQDNFEYQE...EQLsIELPWSDCTEIHKLLEEKLSFSEQQIKKENKI+EKYKQFYLKHNNP.oNFSMQFLEKKSETNGVETLISGFLKFCEDNFQTSKSKSNSLNYaIKKQQDQWaNsIRNENYKIYYRKKY-DNIhRNN	.KLITCFLILVSAVKVNADFNNIQDNFEYQE...EQLhIELPWSDCTEIHKLLEEKLSFSEQQIKKENKI+EKYKQFYLKHNNP.TNFSMQFLEKKSETNGVETLISGFLKFCEDNFQTSKSKSNSLNYYIKKQQDQWFNDIRNENYKIYYRKKYEDNIFRNN..	0	1	1	1
+10644	PF10812	DUF2561		Protein of unknown function (DUF2561)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacterium spp.	20.50	20.50	20.60	21.10	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.42	0.70	-4.72	7	80	2009-01-15 18:05:59	2008-07-28 15:52:41	3	2	78	0	14	39	1	203.10	60	94.39	CHANGED	Mss.p.SAhRc..GsD.shu.-slDRILlGACAAlWLshlGsuVAAsVALhDLGRGapphuusscTsWVLYuVIsVSALlIsuAlPlLLRARRhAcsEPsspshshscpsut..shtsutssspstpcpss....ssuht.ssth.............sstAVDRlWLRsTlslsushGsAhlAVusATYLMAVG+DsASWVuYGLAGlVTsuMPsl.WhalRpLRt	..............MVS.RYSAYRR..GPD.sISPDVIDRILlGACAAVWLVFsGVSVAAAVALhDLGRGFHEhAGsPH.TTWVLYAVIVVSALVIVGAIPVLLRARR..MAEAE..P...As.RP....oGA....u.s..RGGc......oluSGpPA...tRAsA..E.SAP...VpHAcAh..csAAEW...............................SSEAVDRIWLRGTVVLToAIGIALIAVAAATYLMAVGHDGsSWluYGLAGVVTAGMPVIEWLYsRQLRR..................................................	2	1	8	12
+10645	PF10813	DUF2733		Protein of unknown function (DUF2733)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	21.20	21.20	22.60	25.70	20.70	19.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.92	0.72	-7.29	0.72	-4.39	12	28	2009-01-15 18:05:59	2008-07-28 15:54:04	3	1	27	0	0	22	0	32.40	43	45.92	CHANGED	MGs.lhSlC+RRhsPlhDVcGp.IsltcDFE.h	..........MGh.lhSlC+RppNslhDVcGp.IslscDFE.h..	0	0	0	0
+10646	PF10814	DUF2562		Protein of unknown function (DUF2562)	Pollington J, Finn RD	anon	PRODOM	Family	This protein of unknown function appears to be restricted to Mycobacterium spp.	25.00	25.00	26.90	25.80	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.75	0.71	-4.21	7	75	2009-01-15 18:05:59	2008-07-28 15:54:39	3	2	75	0	13	36	0	131.90	70	92.93	CHANGED	LTPRpRLoRGLpYosVGPVDVTRGl....lGLGlcSApSTAutLRRRYppG+LAR....ELAAApEsls.ElAAAQEVVAsLPpslQcA.....Rpt+RR.+RPhllAG.VAVsVLAGGAVsFSIVRRSsp...PEPSPhPPSVEVpP+P	.......LTPRERLTRGLuYSAVGPVDVTRGL....VGLGLQSARS...TAAuLRRRYREGR....LAR....EVAAA.QETLAQELsAAQDVVANLPQALQDA........RTpRRs+++hWIFAG.IA........A.Al.LAGGAVAFSIVRR.SSR...PEP.SPRPPSVEVQPRP............	0	2	7	11
+10647	PF10815	ComZ		ComZ	Pollington J, Finn RD	anon	PRODOM	Family	ComZ is part of a two gene operon. It affects competence regulation by negatively affecting the transcription of the ComG operon. ComZ contains a leucine zipper motif [1].	21.00	21.00	21.10	21.60	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.67	0.72	-4.19	7	116	2009-01-15 18:05:59	2008-07-28 16:00:15	3	1	115	0	14	41	0	55.40	79	83.53	CHANGED	EKoMcFhQIAMKalPEAKt.L-csGI-LohEhlQPhhsLhhpVMsEAYELG+sDAp	......EKSMQFLQIAMKHLPE.AKAILDDNGIALDMEKAQPVLELLMKVMNEAYELGKADpE....	0	3	8	10
+10648	PF10816	DUF2760		Domain of unknown function (DUF2760)	Gunasekaran P, Mistry J	anon	Pfam-B_001564 (release 23.0)	Domain	This is a bacterial family of uncharacterised proteins.	25.00	25.00	116.20	116.10	19.50	18.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.49	0.71	-4.62	29	227	2009-09-11 06:04:09	2008-07-28 16:01:46	3	1	225	0	68	201	15	125.90	59	60.21	CHANGED	psossuALQLLuLLQ+EARhIDFlpEDluuaoDA-lGAAARllHpGC+KlLp-aFolpPVRsE.....sEGoRlolstGFDusplRLTGNVsGpuPFsGsLhH+GW+sscV+LPKlusspDs...s.llAPAEVE	.......sAosDuALQLLuLLQ+EARLIDFlpEDlusaSDtElGAAARVlHsGspKVLcEahTLsPlRsE.....pEtoRloltsGFssppIRLTGNVsGpAPFsGTLlH+GW+ssslpLPKLu-saD.s....o..llAPAEVE.	0	23	34	55
+10649	PF10817	DUF2563		Protein of unknown function (DUF2563)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacterium.	21.20	21.20	21.50	22.50	19.50	21.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.33	0.72	-3.59	3	55	2012-10-01 21:44:22	2008-07-28 16:02:45	3	1	51	0	6	23	0	102.30	73	98.01	CHANGED	MFVDT-LLHSGGNESHRAGGHA+-GADQLAtGPLhSGMFGDFAAADAFHsAVsuAHAQHVRNLQAHpEALTuVGoKAHHAAsGFTsMDspNAsEL+AVRsSuuT	.......MFVDVGLLHSGANESHYAGEHAHGGADQLSRGPLLSGMFGT.FPVAQTFHDAVGAAHAQQMRNLHAH.RQALITVGEKARHAATGFTDMDDGNAAELKAVVCSCAT.................................	0	1	3	5
+10650	PF10818	DUF2547		Protein of unknown function (DUF2547)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	23.10	23.10	23.80	46.00	22.90	23.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.36	0.72	-3.36	8	80	2009-01-15 18:05:59	2008-07-28 16:03:26	3	1	79	0	11	55	0	95.20	43	92.21	CHANGED	KpsFWSQLLhShIAIFALPpsQshphtp....sNcs.QsollpQplsp.ssplspclpQQshaltph.h...t.hpIpPp......Fhssshpap....sPIRAGPhs	....KssFWSpLLLullAIFALPsuQuhp.ps.....ssEN.psol..Q..QhLp.slplsc-spp.Qs.h..sphshpsct.hphpPH......Fhscshshs....APIRAGPl.h	0	1	4	10
+10651	PF10819	DUF2564		Protein of unknown function (DUF2564)     	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	59.20	58.90	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.61	0.72	-3.86	7	123	2009-01-15 18:05:59	2008-07-28 16:06:46	3	1	123	0	17	47	0	78.60	67	93.60	CHANGED	GasDh+QlEhAVETAQKhsGtAT+uhssshlcsAhQAlEsAR.Qhspupphts.lDp.sFltpppplLscspHQLcEucc	.tVNDFEEVKFRVETAQKMVGSATISMDPDTLEHATTAVEAARSQLEIMKSVATDLDE.PFLMNEEKKLs+CEHQLsEA+H.....	0	3	9	11
+10652	PF10820	DUF2543		Protein of unknown function (DUF2543)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Enterobacteriaceae. The family has a highly conserved sequence.	25.00	25.00	103.90	103.70	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.60	0.72	-3.97	5	335	2009-01-15 18:05:59	2008-07-28 16:07:32	3	1	334	0	14	60	1	80.80	93	99.94	CHANGED	MoNDIPLKYYDIADEYuTEoApPVSDuER-sLAHYFQLLITRLMNNEEISEEAQ+EMAsEAGIsEsRIDEIAsFLNQWGNE	MNHDIPLKYFDIADEYATECAEPVA-AERTPLAHYFQLLLTRLMNNEEISEEAQHEMAAEAGINPVRIDEIAEFLNQWGNE.......	0	1	2	8
+10653	PF10821	DUF2567		Protein of unknown function (DUF2567)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.16	0.71	-4.73	19	131	2009-09-11 10:54:39	2008-07-28 16:08:36	3	1	131	0	34	108	0	156.80	42	71.54	CHANGED	GLuusGsLlGuLWAWlAPPIHuVVAlTRuG-RV+tYLGuESppFFsAshhhlGLLSVLAVVAuVhhWQ.WRpHRGPhhVAuLuhGhssAAulAAGVGAhlV+LRYGulDhsssPlop.-+slsYVspAPPVFFu+pPLQIAhTLhaPAulAuLVYAlhAAuTuRDDLGG	.........................GlussGlllGu.LWAalAPPl+u.VVs..hTRsGpplhtaL.G.uES.ppaFh.As.hhhlGLhsVluVVAuslh.Wp.hR.c+RGP.hVuuLulGhssAAu.lAA.uVGuhls+hRYus.....lDhsssPlst..sttls..hVspA..PPlaa...uctslph....Ahs.Lhhs.sslA.uLVYulhAuusuRDDLGs.................................................	0	7	23	30
+10655	PF10823	DUF2568		Protein of unknown function (DUF2568)	Pollington J, Finn RD	anon	PRODOM	Family	One member in this family is annotated as yrdB which is part of a four gene operon however currently no function is known.	21.10	21.10	25.00	24.20	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.20	0.72	-3.76	12	114	2009-09-14 14:03:47	2008-07-28 16:14:56	3	1	105	0	44	113	0	90.70	29	80.50	CHANGED	lhlRFlLELsslsuluhaGaphs.shhh+hslulshP...llhhllWuhFtuPpusp+.......lpGhsRhhlElllFuhushAhhhssp.hhulsaAslhll	............sltFlLELssLssluh....aGaphs...ts......hh....h+hslulhhP...llssllWGhFsAP+.uthp.......l.shh+lhlElhlFus.ushu.lhhhsphhhuhhhuhlhh...................	0	13	33	38
+10656	PF10824	DUF2580		Protein of unknown function (DUF2580)	Pollington J, Finn RD	anon	PRODOM	Domain	This family of proteins with unknown function appears to be mainly found in actinobacteria.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.06	0.72	-3.66	56	605	2012-10-01 21:44:22	2008-07-28 16:17:35	3	2	159	0	185	723	2	97.70	19	80.66	CHANGED	Mo....spLpVpPstL+phAupHspsAsplss...ussus..uhssplttoHGslsuphpsshpthhssRpsshsphtssssclApsLcsAAuhYppsDcssupslcs	................................lpVssstLcshA...up...hsphAsplss.......sssss........st.ss..t.s.ssshG.......h..s..s..t..hs.ss.hp.t...hhst.t....p...s...shsph....s...sshsshApsLpsuAstYppsDpssuttlt.t........................	0	51	128	167
+10657	PF10825	DUF2752		Protein of unknown function (DUF2752)	Gunasekaran P, Mistry J	anon	Pfam-B_001601 (release 23.0)	Family	This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.	20.90	20.90	20.90	20.90	20.80	19.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.45	0.72	-3.94	79	584	2009-01-15 18:05:59	2008-07-28 16:18:56	3	1	475	0	185	535	65	51.50	32	38.74	CHANGED	sCPh+tlTGh..CPGCGhpRuhhsLl+G-lsuAhphNshhhsshshlhhhhhh	................sC.h+tlT.Gh..CPGCGspRuhhsL.lHG-lsuAhphNshhlhs.h.shhshhhh.h..............................	0	71	142	172
+10658	PF10826	DUF2551		Protein of unknown function (DUF2551) 	Pollington J, Finn RD	anon	PRODOM	Family	This Archaeal family of proteins has no known function.	21.70	21.70	22.10	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.80	0.72	-4.08	12	39	2009-01-15 18:05:59	2008-07-28 16:20:34	3	1	26	0	36	39	0	81.70	41	78.54	CHANGED	LcpYLpRDpsGlR+slLplFLcscphThs-la-tLpcc.FsVSh+uVuuMVGllsS+LGILps..sshGspslYpLKEcYtslV	...LpcYLpRDpsGlR+slLplFLcscphTss-lach.Lpcc.FslSh+uVuuMVGlhsS+LGILps..pshsspshYpLKEcYtslV...........	0	7	28	32
+10659	PF10827	DUF2552		Protein of unknown function (DUF2552) 	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.70	21.70	21.80	117.40	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.79	0.72	-4.05	5	119	2009-01-15 18:05:59	2008-07-28 16:21:31	3	1	119	0	13	32	0	78.80	78	98.21	CHANGED	M-QKLKsL+NTAQNKTWVSFLNpNHPYTLLHWSIGGs-SlKKDVWLLQDEMTFETcEFPTLEpAIsWIuENM-pITDVL	.MDKQL+TLRNIANERTWASFLNDNHPYSLLHWSIAGVGQEuKDVWLLQDEVTFQTTEFPTLD-AhpWISENMEQVTDVL	0	1	5	7
+10660	PF10828	DUF2570		Protein of unknown function (DUF2570)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteins with unknown function.	22.00	22.00	22.10	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.48	0.72	-4.46	7	240	2009-01-15 18:05:59	2008-07-28 16:22:39	3	2	193	0	18	152	10	105.20	32	83.99	CHANGED	h.palhu...slshl..ILGLsuWhWhQSppIsoL+AENpsQAQTIppQpcANppLs.tLpQERQAV.tQQchsNElcptsppstEplKoIltppsCA+scLPpuVlD...RLHp	.............................hh..ha.hlul.uhl...llu...hhGh....h.phS..as.lu+.pAc....scsQspTlcspscs...h...shl.......ss.....ulQ........ph......pplltp.ptpsQ.Qhp.p.-....u-.tppE....pl+ssIucDc.CA+s.LPsu..........+ht..................................	1	1	4	12
+10661	PF10829	DUF2554		Protein of unknown function (DUF2554)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	76.00	75.90	18.00	17.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.73	0.72	-3.88	3	416	2009-01-15 18:05:59	2008-07-28 16:23:53	3	1	410	0	11	60	0	67.60	84	99.76	CHANGED	MlTKsLSVVLLTCALFSGQLMAGHpGHEFVWVKNVDHQLRHEADSDELRAVAEESAEGLREHHNWQKSRKPEoaFR	.MhpKslSslLLsCALFSGQLhAtppGH-FVWVKNVDHQLRHEADSDELRAVAEESAEGLREHFYWQKSRKPEAGQR...	0	1	1	5
+10662	PF10830	DUF2553		Protein of unknown function (DUF2553)	Pollington J, Finn RD	anon	PRODOM	Family	This family of bacterial proteins has no known function.	20.70	20.70	21.00	54.20	20.10	20.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.70	0.72	-3.46	8	101	2009-01-15 18:05:59	2008-07-28 16:24:25	3	1	101	0	15	44	0	73.00	59	92.91	CHANGED	pp+lDIT-+VTGRhcsGpLsLYc-NEhIGc..Msuts.QYELKsGYoacspKFY+hsDsssps-tKYVD.CD.EsGWC	.o.hKIDITN+VluKF.+.sshLELYpsc.MIGKFYVYTEsKQYVLEDGYlYEsGKFYRIID.THR.GNspsAEuCD..LGWC...	1	2	9	10
+10663	PF10831	DUF2556		Protein of unknown function (DUF2556)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	71.90	71.60	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.85	0.72	-4.33	3	414	2009-01-15 18:05:59	2008-07-28 16:24:39	3	1	413	0	10	45	1	45.60	92	88.54	CHANGED	MIRKYWWLVVFAVSVFLFDALLMQWIELLoTETDKCRNMNSVNPLKLVNCoDL	MIRKYWWLVVFAV.VFLFDsLLMQWIELLATETDKCRNMNSVNPLKLVNCDEL	0	1	1	6
+10664	PF10832	DUF2559		Protein of unknown function (DUF2559)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appear to be restricted to Enterobacteriaceae. The sequences are annotated as yhfG however currently no function is known.	20.50	20.50	20.60	20.50	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.81	0.72	-4.17	3	338	2009-01-15 18:05:59	2008-07-28 16:27:31	3	2	335	0	17	58	0	53.80	83	95.45	CHANGED	KKLTDKQKSRLWEtQRNpNFQASRRLEGVEVPLVTLTAEEALARLEELRRHYER	...KKLTDKQKSRLWE.pRNtNFQASRRLEGVEhPLVTLTAsEALARL-ELRRHYER......................	0	1	2	10
+10665	PF10833	DUF2572		Protein of unknown function (DUF2572)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.30	20.30	21.20	20.70	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.48	0.70	-4.93	5	87	2009-01-15 18:05:59	2008-07-28 16:28:22	3	2	84	0	12	71	0	200.60	36	82.57	CHANGED	KGllTLTILhLLSulLlIhMLFDDDtL+aHpSlhuQRKlYVpQsLpLQ+hopEQKpslCpcl....PLNoopssppIoFcptutsDu...puaFlWCcRpoLFKppPKKuhNpGuLSpaINcEpluLFpH+FpusPt.Lsss+usYLYWlD-sQsElpIsGsIsAIlIAEGDLKIsGKGRI+GsVITGGsLoLE.uVpluY+KtTVssLVppYSpWQLAEKSWaDFss	...................................................................................................+GhhTLslLlhlSulLslhhLhcDshLphaputtsQRphYVppplpL.chotpccpptC.pl....shspstpshplsh.t..Lp..t...s-u...lpaalWCcR.sLF.p.p.pPp+st.p...s..tlppFls.t..p..tl...shFp..phu..psP.t....sspp.PplYWhss.sps-hplsts..lpul..lIAEGDLclpGpG+IpGslITsGpLoL-..s..l.plsYuKpsVstllppYSpWplAEpSW.DF.........	0	1	5	11
+10666	PF10834	DUF2560		Protein of unknown function (DUF2560)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	42.00	48.60	23.00	20.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.60	0.72	-4.02	2	125	2009-01-15 18:05:59	2008-07-28 16:28:58	3	1	115	0	8	42	0	78.70	72	95.74	CHANGED	MAEIhshTE.QphpL-Ih+LV.spsAAAEcAhtFlusscLphELFK.ph..utupushhsRs.EAlRcuKEALDLFTsGA	...MAEIIPMTEEQKFQLEIYKLVMNQNAAAEEAFQFIGTDELKLELFKIHFQSG.GANSDITTRTIEAVRKSKEALDLFTTGA......	0	0	0	0
+10667	PF10835	DUF2573		Protein of unknown function (DUF2573)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this bacterial family of proteins are annotated as YusU however no function is currently known. This family of proteins appears to be restricted to Bacillus spp.	22.80	22.80	23.00	80.70	22.40	22.70	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.75	0.72	-3.94	7	119	2009-01-15 18:05:59	2008-07-28 16:29:26	3	1	119	0	11	45	0	80.30	77	97.34	CHANGED	tpKhcEQlDGLlEKYTELLLGEos-EhKEcVKtWllYSHIAKSMPPLAKHWNusYP-AK-tlKclIpcIKcLNEt+R..psK	....S.EKFNEQFDGLLEKYTELLLGESNEERKEQVQKWALYSYIAKTMPALVKHWNET..YPDAKEEMVQLITcIK+LNEEKRNE...Q..	0	4	7	8
+10668	PF10836	DUF2574		Protein of unknown function (DUF2574)  	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appears to be restricted to Enterobacteriaceae. Members of the family are annotated as yehE however currently no function is known.	25.20	25.20	26.30	48.90	23.80	25.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.03	0.72	-4.28	4	385	2009-01-15 18:05:59	2008-07-28 16:30:48	3	1	383	0	7	60	0	75.30	65	99.38	CHANGED	MpKYhL.GIIhLAYGluSPsFuSDTATLTIsG+losPTCSh-VVNsQLQQRCGphhahssspppASoPs+GVTTEVlslsusSpRpIVLNRYD	........................................hthVNuQsQQ+CGQLhasVDTpa.sSSPsKGVTTEVVsssuDSKR+IVLNRYD.....	0	1	1	3
+10669	PF10837	DUF2575		Protein of unknown function (DUF2575)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appears to be restricted to Enterobacteriaceae. Members in the family are annotated as yaaY but currently there is no known function.	25.00	25.00	29.70	29.70	19.40	17.80	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.47	0.72	-3.88	2	193	2009-01-15 18:05:59	2008-07-28 16:31:56	3	1	192	0	4	26	0	68.10	82	99.23	CHANGED	hpHSLRSDGAGFYQLAsCEYShShhKIAhuGtFhsslCpMAMKShFFhhp.hNRRLTLTAVQGILhRFSLF	................hpHSLRSDGAGFYQLAsCEYShShRKIAhuGtFhsslCtM..AMKShFFhhs.hNpRLTLTAVQGILhRFSLF.........	0	1	1	3
+10670	PF10838	DUF2677		Protein of unknown function (DUF2677)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as UL121 however currently no function is known.	20.90	20.90	21.00	31.50	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.06	0.71	-4.59	4	34	2009-01-15 18:05:59	2008-07-28 16:32:48	3	1	14	0	0	29	0	163.10	63	91.10	CHANGED	hsllh.sstGstss.hCssspsplKlpChL.pLDpRLaW.lpDop....RVhsFc.-spp.hs...........apV-VRtsh.ssp.asl.LhhPLh.psTVuLLL.DhtpsR.EclLChuhlPph+tlpsCthDsDLulLYuVCllLSlSlVsAulhKlDYDpoht..hpuYKS	..............LMChALMARGTaGAYICSPNPGRLRISCALSV..LDQRLWWEIQYSSGRLTRVLVFH.DsGEcGDD.........LHLTDTRHCTSCTHPYVISLV.TPLTINATLRLLIRDGMYGR.GEKELCIAHLPTLRDIRTCRVDADLGLLYAVCLILSFSIVAAALWKVDYDRSVAVssKSYKS.....	0	0	0	0
+10671	PF10839	DUF2647		Protein of unknown function (DUF2647)   	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins are annotated as ycf68 but have no known function.	22.30	22.30	23.70	26.30	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.46	0.72	-3.90	4	31	2009-01-15 18:05:59	2008-07-28 16:33:42	3	1	25	0	6	19	0	67.80	65	51.29	CHANGED	AYSSCLsRohhssKLLLRRIDGAIQVRSpVD.TFYSLVGSGRSGGsP.....susLhpp.aIsh.sh.uhLStst	..............AYSSCLNRSLKPNKLLLRRIDGAIQVRSHVDhTFYSLVGSGRSGGGs......st.L.SR.pIp.lSVautLShpp....................	0	0	0	2
+10672	PF10840	DUF2645		Protein of unknown function (DUF2645)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins appear to be restricted to Enterobacteriaceae. Some members in the family are annotated as YjeO however no function for this protein is currently known.	25.00	25.00	26.10	25.70	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.53	0.72	-3.86	5	170	2009-01-15 18:05:59	2008-07-28 16:39:21	3	1	157	0	19	68	0	99.80	65	98.68	CHANGED	MS.+htlLsthYhIlChLhIhlhSsLDcEaMIDGp-IsNlC-VhRtl.sDDoRDFsuhhsLPLhhPFFasslh++hKShFLsllullLluYWlWpFFIRapFC	........Ms.pMFlLCCIWFIVAFLWIsITSuLDKEWMIDGRGINNVCDVLhYLEpDDTRDV.GVIMTL.PLF.FPFLWFA.....LWR.....KK.RGWFMYATA....LA.IFGYWLWQFFLRYQFC....	0	1	8	10
+10673	PF10841	DUF2644		Protein of unknown function (DUF2644)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Pasteurellaceae.	20.90	20.90	20.90	23.00	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.96	0.72	-3.94	10	46	2009-01-15 18:05:59	2008-07-28 16:40:06	3	1	38	0	8	46	0	58.90	55	70.91	CHANGED	pELITNsDGRLSTTuFIQFaGALlMAGILlYuVaLDRsYVsELFssFAlFCG.GusATKGh	..ELlTNs.DGRLSTTuFIQFFGhLlMAuILhauVYLDRshVs-LFhsFAhFCu.GusATKGh..........	0	1	6	8
+10674	PF10842	DUF2642		Protein of unknown function (DUF2642)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillus spp.	20.80	20.80	20.90	20.90	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.09	0.72	-4.48	10	100	2009-01-15 18:05:59	2008-07-28 16:40:24	3	1	82	0	24	81	1	61.00	45	78.44	CHANGED	uPQlVSllDPYVYQTLQollGcclVVpTlRGolRGpL+DVKPDHlllEus.pslaaIRlQQIVhVhP	............phluhssPYVhpslppllGpplVlET.VRGsl.+G.pLcDVKPDHl.llE.s....sssahlRlpQIValhP..........	0	8	18	18
+10675	PF10843	DUF2578		Protein of unknown function (DUF2578)	Pollington J, Finn RD	anon	PRODOM	Family	This is a Saccharomycete family of proteins with unknown function. The protein in S. cerevisiae is strongly induced in response to many stress conditions and is repressed in drug resistant yeast strains.	25.00	25.00	144.70	143.00	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.33	0.71	-4.63	12	62	2009-01-15 18:05:59	2008-07-28 16:41:18	3	1	42	1	37	43	0	168.30	55	97.50	CHANGED	Mo.KKcKp.....................PKspohohpSsES...............lKsFEDLpsFEsFl+sET..Ds-FDahHs+LpYYPPFVL+EsH--.EKIKsTsNp+SKKFhRcLppHlcKHLlKDlccshth.-L+FcctucpEoFs+lsW+atDpo-a.........asR+a+lplsVoCpp-sAMVDVDYKohP	..........................hpc.........................pKtPKhpTloTcsGEo...............lKVFEDLpsFETal+sETE.D.s.-FDalHC+LpYYPPFVLH-uH-.DPEKIK-TsNSHSKKFVRHLHQHlEKHLLKDIKpAlshPELKF+-KsKcEoF-.+......IsW+Ys-ET-a.........asR+FKlpVpVsCsH-sAMV-VDYKThP..	0	4	18	31
+10676	PF10844	DUF2577		Protein of unknown function (DUF2577)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function	21.50	21.50	21.90	24.40	21.40	20.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.26	0.72	-3.96	46	176	2009-01-15 18:05:59	2008-07-28 16:41:52	3	2	132	0	36	161	2	103.90	26	92.34	CHANGED	chlcphutsshpsspPspl..hhGpVlossP.Lplplsp..p.llLspc...Lhlsc.hlpchphphphpt..tp....................................................hhhpssLchGDcVlllp...psG.QpalllD+l	...............hlpthuhpuhpsspPspl..hhGcVhossP.Lcl.plsp..p..llLsp-.....lllsc.plpphphphphpt...t................................................................h.h.ssLcsGDpVhllp......hpuG.QpahllD+l...................	0	18	30	31
+10677	PF10845	DUF2576		Protein of unknown function (DUF2576)	Pollington J, Finn RD	anon	PRODOM	Family	The function of this viral family of proteins is unknown.	20.40	20.40	20.60	21.50	19.80	17.60	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.47	0.72	-4.80	13	18	2009-01-15 18:05:59	2008-07-28 16:43:07	3	2	17	0	1	15	0	44.90	69	27.79	CHANGED	NAPVVsSpHDYDR-QI+RELNSLRRsVH-LCTRS.uTuFDCN+FLcSsD	....NAsVVsotpDYDR-Ql+RELNSLRRsVH-LCTRS.uTuFD.CN+FLcSsD..	1	0	0	1
+10678	PF10846	DUF2722		Protein of unknown function (DUF2722)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	21.00	21.00	21.10	21.70	20.20	20.90	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.57	0.70	-5.44	11	93	2009-01-15 18:05:59	2008-07-28 16:44:51	3	2	76	0	69	95	0	283.10	20	67.85	CHANGED	M................poh.t..p..pphsspspsppppp...............................................................................................................suL.sLLGsNVssaPaSEsuhlculcL+sEQE+TKQpYYKLEssNKslpllcpAlpApIPsNhIPhLa..h.Nss.......................................................................................pspspspsss.spss.spssusshlsspp.s.............psPhsY+Fsssosss.............p.h..sspRRshSPA+IGAu.....AVAsLusssssh+............ptsssshR+...p.spsHpRphShPs................................ptspsssp.ps........................sTSslphps.sspslp+pstssspssp-.hToh.Hhl....h+.t.......................................p.p+cH.....+Rp+Ss.othtsIDLs..s.......t...............p.scss-ssp+pppspppps.......s....................................-Dpsho.soSh....................spsssposht+hPpsls..ph.N.s	..............................................................th...........................................................................................................................................................................................ph+.EpE+T+Qphh+LEptphph-lL+huhpuGlPsshIPhlF....hsssst.hs.t............................................................................................................................................................tp.t..tpttp.tpp..th.tss....t..p..............................s..hth.s......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ss......................................................................................	0	9	34	60
+10679	PF10847	DUF2656		Protein of unknown function (DUF2656)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	23.00	23.00	23.60	23.00	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.64	0.71	-4.23	12	19	2009-09-16 17:37:28	2008-07-28 16:45:57	3	1	18	0	8	18	18	129.70	41	90.86	CHANGED	hFlLSHNLQlpSshVPulusp-LApGL...hupustlpsspsLsHPHWhVclc...SsLSsp-hAp-LVcuWcphRpsh..GHshsHslLALGGRKDot.usPGuP..LQpGpWGVDVVEssss-sFLpuINW-ALKuGRPsD	.........hhlLSHNhplpss.VPslshp-lApsl...hsppstlpsspslsHPHWhVclp.....ushSspchupthsp.uWpphRpuh....ucshsHslLALGGRKDos.ussuuP..LQpGtWGVDVVETsss-sFLpuINW-uLpuGRPtD.......................	0	2	3	6
+10680	PF10848	DUF2655		Protein of unknown function (DUF2655)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	41.10	40.60	21.30	16.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.96	0.72	-4.12	2	140	2009-01-15 18:05:59	2008-07-28 16:47:03	3	1	139	0	2	13	2	81.30	87	84.83	CHANGED	hSVAphShGpTAQLStKQsGaYSPEhh.STGKDCNPQPANCLKsQYVLRHCCVDDRSsKMGYSsKhhVLTphssETASLFHC	.....MSVAphShGpTAQLStKQsGaYSPEhh.STGKDCNPQPANCLKsQYVLRHCCVDDRSsKMGYSsKhhVLTphssETASLFHC.	0	1	1	1
+10681	PF10849	DUF2654		Protein of unknown function (DUF2654)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as a-gt.4 however currently no function is known.	25.00	25.00	73.00	72.40	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.42	0.72	-4.24	13	35	2009-01-15 18:05:59	2008-07-28 16:48:29	3	1	34	0	0	26	0	70.20	49	63.06	CHANGED	AcKKApKhL+KNpREIcRL++HAEpAlhssN+-tYhYAIpKLRsIhKQ.Phsc-llpshWhToRpQlh-hl	...Ap++AsKlL+KNpREIpRLp+HAptAlhsNNhstYtYAIpKLRcIhKQ.Phs-ELlphhWpToRpQI.-hl.......	0	0	0	0
+10682	PF10850	DUF2653		Protein of unknown function (DUF2653)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	21.60	21.60	23.10	47.00	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.03	0.72	-3.68	4	127	2009-01-15 18:05:59	2008-07-28 16:49:31	3	1	127	0	16	75	0	81.40	66	89.06	CHANGED	MppI.IsEQ-IIsAlClYIApp+pItPE-V.V.ELhYDDcoGFuAElpsshppp.LhosslIpALR.alc-.hpsNPausslcLpLDcccGIh	.........l..p-llsulClahupcctltPE-V.V.ELMYDDDYGFSAEVEVN.GR.Q.QILIQANLIEALRLLLDREYNVNsFAARLQLELDDEEGIY....	0	5	12	12
+10683	PF10851	DUF2652		Protein of unknown function (DUF2652)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	22.10	22.10	22.60	32.20	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.45	0.71	-4.09	6	72	2009-01-15 18:05:59	2008-07-28 16:50:17	3	1	65	0	15	46	51	104.00	71	46.52	CHANGED	lApLLEuVI-Au.psLKLAKLEGDAAFFaAsssssssh.lscphstMRpuFhpRREphc+D+.CpCcSCtQlcsLSLKFVAHtGEVApQ+VK+psELAGhDVILVHRMLKNpVPVsEY	.......VAQLLESVIDAu.KGhKLAKLEGDAAFFWAPGuNsSVl.VC-RsspMRQ+F+sRREQIKKD+sCDC+SCpQt-sLSlKFVAHpGEVAEQKVKRNVELAGVDVILVHRMLKNEVPVSEY....	0	4	9	13
+10684	PF10852	DUF2651		Protein of unknown function (DUF2651)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus spp.	25.00	25.00	28.40	28.10	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.94	0.72	-3.62	4	152	2009-01-15 18:05:59	2008-07-28 16:51:26	3	2	106	0	11	94	1	77.30	58	96.00	CHANGED	MsEL.hsFhIhPLhIhIlSIsGThhhKshYlMPhlohslhLllshTlas.uFhhWsshYollSFhlSYITllhl..hc.spN	......MsELIFllhIhPLhIhIlSVlGTpKsKTaYVMPIVTFu..sF..LIlsVhsF..sPpFFFWVGMYSIhSFIVSYhTLLF...V+GYclsE...........	0	2	7	7
+10685	PF10853	DUF2650		Protein of unknown function (DUF2650)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Caenorhabditis elegans.	22.90	22.90	23.80	23.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.24	0.72	-4.50	7	51	2009-01-15 18:05:59	2008-07-28 16:52:14	3	1	9	0	51	41	0	37.20	38	31.25	CHANGED	CPppolaaaacCCGphspECChpLpsWVhlhLhlhhls	..CPpsohaaaacCC....Gpts....p....-CCaplpsWlhlhLhlhhh.............	0	19	24	51
+10686	PF10854	DUF2649		Protein of unknown function (DUF2649)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as Plectrovirus orf 10 transmembrane proteins however currently no function is known.	25.00	25.00	27.70	27.50	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.57	0.72	-3.86	4	27	2009-09-10 17:06:49	2008-07-28 16:52:44	3	1	6	0	0	26	0	66.10	69	99.22	CHANGED	MQNDWIKLKEFFIaIFLFIDKTNVESIpMWNLTQNEYLTLMVGVWlVILFLTWFFLWMVFKIVGYFK	............MQNDW.KLKEFFIHIFLFIDKTNVESIThWNLTQNEYLTLMVGlWIVILFLTWFhLWMlFKIVuYFK................	0	0	0	0
+10687	PF10855	DUF2648		Protein of unknown function (DUF2648)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillales Staphylococcus.	19.80	19.80	21.20	20.60	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.59	0.72	-4.52	3	72	2009-01-15 18:05:59	2008-07-28 16:52:57	3	2	72	0	4	21	0	32.80	78	72.31	CHANGED	MKKLAVILsLuGAAFYGFKKYQN+VNQAPNIEY	MKKLAVI....LsLsGuhaYuFKKYQ.p+VNQAPNIEY..	0	0	0	4
+10688	PF10856	DUF2678		Protein of unknown function (DUF2678)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.10	25.10	28.00	28.00	24.30	23.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.72	0.71	-4.36	4	64	2009-01-15 18:05:59	2008-07-28 16:56:09	3	3	51	0	39	49	0	105.60	58	82.36	CHANGED	M--apTRo.GT....ppPLFGETpsRDRIlNLslGGhTSlLVL.ThlSuhVFPp.PP.slNIFFslCIhhhs.osllL..............................IFWYRQGDL-PKFRsLIYY.hholVLLClCANLYFHDVt+	...................M--asoRTYGTu.GhDN...RPLFGETSA+DR.IINLlVGuLToLLlLV.TlISAFVFPplP.P+PLNIFFAVCI.LssloshlL..............................IaWYRQGD..L-PKFRpLIYYhlhSIlhLClCANLYFH-Vt.......................................	0	13	16	24
+10689	PF10857	DUF2701		Protein of unknown function (DUF2701)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	25.00	25.00	25.30	96.90	24.90	19.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.85	0.72	-4.20	7	13	2009-01-15 18:05:59	2008-07-28 16:57:47	3	1	13	0	0	12	0	63.50	42	74.66	CHANGED	lslhllslshlsalLlYLl+WohlhshhsplKl+llph..TTRRSFppLDsVYYTsDspV.GlNlE	.lslhlllIsIlsaLLlYLl+Woalh-hhNclKl+llph..TTRRSFscLDsVYYTDDspV.GVNVE	0	0	0	0
+10690	PF10858	DUF2659		Protein of unknown function (DUF2659)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	34.80	34.80	34.90	326.80	34.70	34.70	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.52	0.70	-4.94	3	43	2009-01-15 18:05:59	2008-07-28 16:58:51	3	1	43	0	7	30	1	220.10	83	99.91	CHANGED	MTDILDEVLsDcNEEKRLIFFKKLLPIVIIISLIAITIMVINNNNKs+QIcNNQKNGDIFVKoVsLEospsNcELAlsTLEN.LVosSNTKIQEIAtLEQVAIKISsppaSEAKDLLNKIIENKEYSEIoTSYARIuWCSLVI.....DDcNLDIsDKEKLlKYLNYFDDEsKPFWATAoIhKAIWDIKNNMcscAEKNL+uLltSNNoSDLLKDQAKALLsNL-+	MTDILDEVLSDQNEEKRLIFFKKLLPIIIIISIIAITIMVVINNNKDKRIKNNQKNGDILVKTVGLETTKDNcELAFNTLEN.LVTTSNTKIKEIAALEQVAIKIScKKYSEAKDLLNKIIENKEYSEISTSYARISWCuLVl.....DDpNLDIQDKEKLTKYLNYFDDEKKPFWATATIIKAMWDIKNNMKsQAEKNLKNLLISNNVSDLIKDQAKALLVNLNK.	0	1	2	2
+10691	PF10859	DUF2660		Protein of unknown function (DUF2660)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteins with unknown function.	25.00	25.00	41.40	131.50	20.10	18.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.95	0.72	-3.76	4	44	2009-01-15 18:05:59	2008-07-28 17:00:12	3	1	44	0	7	28	0	86.70	82	63.36	CHANGED	LhY.KIss+KKNhhsuptNNI--o.slALNsppp-NK...KLTLQE+IELSWpFLYDITEsILNKFSKEDlhpVNKCGplLaENGVRYEH	LMYKKIAARKKNILPApGGNIDDSPNVALNSQKPENK...KLTLQERIELSWpFLYsITEVILNKFSKEDVIQVNKCGQVLFENGVRYEH	0	1	2	2
+10692	PF10860	DUF2661		Protein of unknown function (DUF2661)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins have no known function.	20.80	20.80	20.90	25.50	20.00	19.30	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.77	0.71	-3.90	7	19	2009-01-15 18:05:59	2008-07-28 17:02:46	3	1	18	0	0	18	1	103.30	41	36.17	CHANGED	hsLVaVWYH.cspFlaNospaPFWHNlhYpuppYpsallYal-Npss..lPt....stslphlsFKchhscc.phppLpshhs...KIDYMKLpllhs..............schl..spphlLLMDMDCsl	.hsLVaVWYH.cspFVhNTspaPFWHNlpYauppacshVlYhl-sps..sh..pl..Ps...stslphlNFKcshsph.phsplpslhp...KIDYMKlshlhs..............schl..spsalLLMDMDCsl.	0	0	0	0
+10693	PF10861	DUF2784		Protein of Unknown function (DUF2784)	Gunasekaran P, Mistry J	anon	Pfam-B_001600 (release 23.0)	Family	This is a family of uncharacterised protein. The function is not known however it is conserved in Bacteria.	22.60	22.60	22.70	24.30	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.70	0.71	-4.28	45	266	2009-09-11 08:43:52	2008-07-28 17:03:21	3	1	255	0	81	218	171	116.00	35	92.57	CHANGED	YpllADhllllHhhFllFVlhGGlLll..........Rh.thhhlHLsAluWushlphhGh.hCPLTsLEshLRptAGpsuY.suGFl-HYlhsllY......PstlssslphhlGslVlls....ashlhhRp	..........thhADhlllhHhhFllFVlhGGhLsh...........RhhphhhlHlsAlsWGsulth...h.sl..sCPLThlEshLRptAGtssh.ssGFlpHYlhsllY.......Psshs.ssspllhuslVlhs......ahhhh...h.............	0	24	57	71
+10694	PF10862	FcoT	DUF2662;	FcoT-like thioesterase domain	Bateman A, Pollington J, Finn RD	anon	PRODOM	Domain	Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis [1] suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups [1]. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.	20.80	20.80	21.00	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.09	0.71	-4.69	6	71	2012-10-02 20:54:35	2008-07-28 17:09:44	3	2	71	2	9	28	0	151.50	66	81.73	CHANGED	+VLcPYp.csCRYLlcA..........ph+Ap.sulhAhGsFsIsESsYIcsTGHFNAVEl.lCaNQLuYshhApuVtNc.IssLcuWSl-DYhc+QLSshLItphSSpF+KPlNPpKFSGRlps+slphhp+o..h.aLhlssshcFWD-sGGtupGEs.LAh	..............RVLEPYSCKGCRYLIDA..........QYSATEDSVLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPAVLNEEIRV....LRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERT...WRYLKVPCVIEFWDENGGAASGEIELAA.......	0	3	7	9
+10695	PF10863	DUF2702		Protein of unknown function (DUF2702)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	56.30	51.40	21.60	20.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.85	0.71	-4.47	8	43	2009-01-15 18:05:59	2008-07-29 08:49:20	3	1	41	0	27	41	0	140.30	44	69.44	CHANGED	MSRupEIK-KpsLQA+lQhuFSsssuKVLuWLpsStppssussh...tp....s-hs-S+cuFhcLPVlQhGSGLohp...pstspssssIpTIGDFIcSDKclSoLuKcK+spps...pppsslaRlsK-DTKAMlALKpKMRsppRcplRcc	...MSRtKEIpEK.sLQAKLQ.oFSsNsutVLsWLcpsppss.s.sst...pp................p-lp-u+cuFacLPVlphGSGLpFt...pts..tsspc-IpTIGEFI...puD.KKlSoLuKKK++sp.ss.....pRs...shaRlsKDDoKAMlALKpKMRcsp+-slRpp.....	0	3	13	24
+10696	PF10864	DUF2663		Protein of unknown function (DUF2663)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as YpbF however currently no function is known.	22.90	22.90	24.10	24.50	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.69	0.71	-3.93	10	52	2009-01-15 18:05:59	2008-07-29 08:50:26	3	1	51	0	18	47	0	129.20	42	87.62	CHANGED	QMLpALIcRKcKaE+hc+QshhhphAullshshallalhsKshu...hphsthLutlhusssaLhhlLssuhuYssuhYaKKKcEKAEsEaHtLRCEIIQKSpDLWsppEpW+uRcpVFchMK+cYDINLYaE	.....QMLpullcRKpKaEphtcpshhaphsullshslhhlalhhpshs....ts.phhlpthlupssaLhallhsuhuY.hsuhYaKKKcEKAEs-FHpLRCEIIQKSsDLW.ps-pWcsRcplFchMK+cYDINLYaE........	0	4	11	14
+10697	PF10865	DUF2703		Domain of unknown function (DUF2703)	Pollington J, Finn RD	anon	PRODOM	Domain	This family of protein has no known function, but it may be distantly related to the thioredoxin fold. It contains the CXXC motif that is characteristic of thioredoxins.	20.10	20.10	20.80	21.60	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.70	0.71	-4.18	14	60	2012-10-03 14:45:55	2008-07-29 08:51:33	3	10	50	0	45	62	2	107.50	29	63.03	CHANGED	LsIcWp+Lsss.stTC-RCusTucslppAlppl+phLp.hGlpVplpcttlsspphuht...hESNpIhIsG+slEphl.uupVsposC....Chss.sDscCRslphssppYEslPtcLllcAu	.................l.Ipa.hLshs...TCsRCtsTtpslpcAlpplpthLp.hGlclhlpch...plss...p..phsht.......pSspIhlsGpsl-.hh.shpsspohC....shss.ssspCRsh.thp.G....ppY-shPtthIhcAh.........	1	21	40	43
+10698	PF10866	DUF2704		Protein of unknown function (DUF2704)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	19.90	19.90	23.70	22.80	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.17	0.71	-4.87	12	19	2009-01-15 18:05:59	2008-07-29 08:53:22	3	1	19	0	0	16	1	161.50	41	78.97	CHANGED	sss.sss-tpssRKsVcuss-EYTVDGLKLKstYVtYYKpLphlVDFhVMhlSKplsMKEY-pVYSLGRQLYElLRulFVDEPFKLWLEpNspchsss...+cpIhKhLQspLphslt....hKosTFKshlhNlLNocLs...s+YDsustYIKPNCIVsTaNCCsLsFc.	.............tsss.......tpspp+slcs..cpaTVDGL+LKosYVtYYKQLKtLV-hlV..halSK.plshK-YcEVYoLuRQLYEllRulFV...DEPFKLWLEp.....NsppLsss..tth+D..cIaKpLpspLcsssss.......scssThKshllNVlNscLstp.scaDssstYlKPNCIV.TasCCsLsFc..............................	0	0	0	0
+10699	PF10867	DUF2664		Protein of unknown function (DUF2664)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is a viral family, annotated as UL96. Currently no function is known.	21.20	21.20	21.20	29.40	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.86	0.72	-3.36	8	32	2009-01-15 18:05:59	2008-07-29 08:54:00	3	1	29	0	0	24	0	91.60	35	73.95	CHANGED	MRhsLE+pQ+cFL+pshGscHPLospQslpsh+stsRpps+psppslpsVustlh.cp+tpl+........cppppA+pLQ+.hDlD-hlDoLsElKDs	.....MRhcLE+pQ+pFL+csaGspH.LoppQulpshcsss+pppc.sppssppVustlh.cp+uplp........p-hpps+pLpp.hc.VD-hLDoLsElKDs...................	0	0	0	0
+10700	PF10868	DUF2667		Protein of unknown function (DUF2667)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Arabidopsis thaliana.	20.90	20.90	21.10	21.20	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.60	0.72	-3.61	5	19	2012-10-01 23:31:40	2008-07-29 08:56:03	3	1	4	0	17	30	0	84.20	29	94.17	CHANGED	MGSLRLSTVAIA.VVVCLSILLISPTEVDGRtVCDhstGtCosh...STCs-sCpslc....usFpGGECtshuuhsGholCaCC+s...VpSuAEhESM	..................h.slh.lllClSlL.Ll....SPh.....c...lsG..p..h..C.D.h.......hGsCs.h......tppCscsC+php....ppatGGpChshst.ss....shChCCh...............t.........	0	10	10	11
+10701	PF10869	DUF2666		Protein of unknown function (DUF2666) 	Pollington J, Finn RD	anon	PRODOM	Family	This Archaeal family of proteins has no known function.	22.00	22.00	22.60	33.90	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.74	0.71	-4.12	9	43	2009-01-15 18:05:59	2008-07-29 08:56:51	3	2	30	2	32	46	0	127.30	38	94.58	CHANGED	E-+IpFTAK+GKWhVlK+LhIDEpTspl-IARLLASIsETlstKI.-Fhs..hDhc+Ic-hhsthhchKK....EE-Iscslpth+S.tsophhst...ppEs+.hl+ch........Lp+LGlphcVsuK.lEKYlEKs	...................E-+IpFsA.....K+GcWhVsK+LhID-pTpsh-IARlLASIsETlstKIP-YLs..hDlctlpphhc-lhphKK....-c-Ispslp+LKSPuTo+Klsphhppc-tK.hLKchL.p...hlLpRlGlppclssK.lEKYlEK.......................	0	3	4	19
+10702	PF10870	DUF2729		Protein of unknown function (DUF2729)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	20.20	20.20	79.20	79.00	19.80	18.40	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-9.07	0.72	-4.24	8	13	2009-01-15 18:05:59	2008-07-29 08:59:52	3	1	13	0	0	13	0	54.80	65	84.38	CHANGED	NLLsYCKLKLVKpVSKTVuuLLCKCV....APEDo.D..sGDRYlQINNNCNFIYINVVp	.pLLTYCKlKLVKuhSKphuuLhC+CV...hus-Ds.D...GDRYhQhNNNCNFIYINVVK.	1	0	0	0
+10703	PF10871	DUF2748		Protein of unknown function (DUF2748)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	25.00	25.00	791.70	791.50	18.90	18.70	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.60	0.70	-6.07	2	44	2009-01-15 18:05:59	2008-07-29 09:06:05	3	1	44	0	7	27	3	439.80	89	99.98	CHANGED	MoslYHILc+lPAI.+pDM.lEYEpLA.pLlpSGKLRlDs-sphNFsRhoEPuLNlslhlSpEELssP+L..cTpthh.NlY+p.hpc....pKlppIhssLpKphth..sVcp-lh.hLARlFVQSAHPIVI+WLLLp+sEVFloYSppIGDhMDhsoWphsGtNSGMQShNGpslAIaVSCGGNP..Fspp.p-pshYGsGasAhARLQIIAAQELGHaADIhRD.pup.lsRHSsN.ShTKApspVhhAR+sDl.+CaplLppL.psGhpp.lsYEpplKFYptNKVpGlKlhhh+hh.FhYK.+Lh.h.pppshIFV+haKs-pY.uLMlcAMhhDM.uNLpPtA-VYKpcsP-hEEAIAClEALARVPQQsIKWGalTThphMpDLYhIYYppVIPSLIspYphITGcsY.Rsh.....NahSph.hap.KKL..hhK....PsREl	MTSIYHILDRVPAIYKQDMEIEYEHLAMQLIKSGKLRIDTDDCCNFARFTEPALNISLMVSpEELTSPHLIPETTKLFQNLYRNSASD....QKIKSIFDNLKKQIQKLQPVKKEVTEMLARIFVQSAHPIVIRWLLLNKTEVFLTYSHNIGDMMDMVSWQRVGGNSGMQSTNGKDVAIFVSCGGNP..FAENNKDHPTYGNGFAAsARLQIIAAQELGHFADIKRDDKGRQITRHSANFSGTKATDKVRIARKNDIIHCHNLLuKLLKAGMKKQLDYETKLKFYNANKVSGLKVYAIKFMIFIYKFRLLNYSSRNNLIFVRKFKTDcYMALMI-AMFKDMQANLSPsADVYKNKNPEIEEAIACIEALARVPQQTlKWGYLTTKETMHDLYKIYYNEVIPSLITSYNAlTGENYpRDFKKPKSNFFSKINIFSNKKL..VLK....PVREL.	0	1	2	2
+10704	PF10872	DUF2740		Protein of unknown function (DUF2740)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function has a highly conserved sequence.	25.00	25.00	30.20	122.00	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.46	0.72	-4.30	3	83	2009-01-15 18:05:59	2008-07-29 09:12:15	3	1	81	0	1	6	0	48.00	94	100.00	CHANGED	MPKQLSPDQDKLHKNILRDRFLSSFKQPGRFRAELEKVKLMQKEKGHE	MPKQLSPDQDKLHKNILRDRFLSSFKQPGRFRAELEKVKLILKRKGHE	0	0	0	0
+10705	PF10873	DUF2668		Protein of unknown function (DUF2668)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as Cysteine and tyrosine-rich protein 1, however currently no function is known.	26.20	26.20	26.40	26.40	25.50	26.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.20	0.71	-4.06	5	49	2009-09-16 09:25:17	2008-07-29 09:12:45	3	2	35	0	26	38	0	129.00	62	85.86	CHANGED	MDALR..LPRRPGVLL.KllLLFVYAGDCpAQCGK-C+SYCCDGSTPYCCSYYAYIGNILSGTAIAGIVFGIVFIMGVIAGIAICICMCMKNNRGTRVGVIRAAHINAIS..YPM.APPPYTYDHEMEYsTDL.PPPYSPAPQASAQRSPPPPYPGNSRK	....................R.....tshlhL.cllLLhlhA-cCLA.QCGpDC..+SYCCD..GoTPYCCSYY.AYIGNlLS..GTAIAGI...VFGIVFIMGVIAGIAICICMCMKNp.Ru.TRVGllRTo+INslo......oYPh...sPP.PYsY-aEMpassDL.PPP..YoPsP...ptssphSPPPPYPG.s+K.......................	0	4	7	13
+10706	PF10874	DUF2746		Protein of unknown function (DUF2746)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	21.90	21.90	22.20	22.20	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.90	0.72	-3.78	5	73	2009-01-15 18:05:59	2008-07-29 09:14:46	3	1	72	0	1	59	0	60.10	54	51.59	CHANGED	I+pQVsNoHDTNlRDDLD-lt..........EhVp-GF+clc+DIstL+E-LsTERpERIEGDRRR-	..I+-QlsNTH..-TNMRDDLD-lt......................................-hV...+-GF+plp.......R.DIuGLREEL..RTERlERIEGD+R+........................	0	0	1	1
+10707	PF10875	DUF2670		Protein of unknown function (DUF2670)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	29.50	39.60	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.65	0.71	-4.14	3	44	2009-01-15 18:05:59	2008-07-29 09:15:40	3	1	44	0	7	29	0	139.20	78	86.46	CHANGED	MWQALRRLIAANPMGFFLWSIITKWYLIIAVASLITLYYTVLGLKKIGFIDYFGRTTVEILDTSKAVAQNCTsKLGPNWs+LVN.......FWNCLSDPGEYcHEEGTGAKVLEDEINKLhsKQAD......SluDscsPIINPYEcLsNsN	.......MWQALRRLhAANPMGFFLWSIITKWYLIIAVASLITLYYTVLGLKKIGFIDYFTETTVEILDTTKAVAQNCTTKLGPNWN+LVS.......FWNCLSDPGEYKHEEGTGA+VLEDEINKLTPKQAD......SlADAE+PIINPYEtLENsN..................	0	1	2	2
+10708	PF10876	DUF2669		Protein of unknown function (DUF2669)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	34.40	34.30	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.57	0.71	-4.45	4	30	2009-01-15 18:05:59	2008-07-29 09:16:31	3	1	24	0	4	23	0	126.40	50	93.33	CHANGED	hpIEslTYsMTPANAhsAWsuLKpAhtLLpusDlsslGcpps..huushLsslLuNLGDPulptlEslVLKaTosc.tDGppYRLS..-RFspHFNpaRuHLl.VLhEGLhYQaADFFhGGsuhhssh.s.hstsp	.....hpI-slTYhMTPANAMsAWpuLKpAhsLLpuhDhsuluNsps.....huussLuslLupLGDPulpElEslVhcpTuhcssDGsp.YRLS..DRhspHFNs+RsHLl.VLhEGlhYQauDFFsGGhuuhpsl.P..sApp.......	1	0	2	3
+10709	PF10877	DUF2671		Protein of unknown function (DUF2671)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Rickettsia spp.	25.00	25.00	31.50	186.70	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.16	0.72	-4.19	2	42	2009-01-15 18:05:59	2008-07-29 09:17:29	3	1	42	0	6	19	0	90.00	93	99.82	CHANGED	MQEKELSNNFLEEQpp.KEDsSPF.DlKYICQASLLITDSIRKGYDVTQLsNGDINVTElRIVNVHYNWNSEKGKFVKTNQIEFNNsKGG	MQEKELSNNFLEEQE...KSKEDsSPFFDVKYICQASLLITDSIRKGYDVTQLPNGDINVTEVRIVNVHYNWNSEKGKFVKTNQIEFNNSKGG.	0	1	1	1
+10710	PF10878	DUF2672		Protein of unknown function (DUF2672)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Rickettsiae.	20.70	20.70	23.40	38.90	19.20	17.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.25	0.72	-4.24	3	43	2009-01-15 18:05:59	2008-07-29 09:18:14	3	2	43	0	7	19	0	67.80	79	64.98	CHANGED	hIIKclKKIKAYF..IKS.hIKNIDcSLETEQlNFYLKKIINLEGYYaGNYDLTTIKEKYYTLI...INNDL	..........IIIKELKKIKAYLINIKSSIlKNIDEPLETEQlNFYLKKIINLEGYYHGsYDLTTIKEKYYTLI...INNDL.......	1	1	2	2
+10711	PF10879	DUF2674		Protein of unknown function (DUF2674)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be conserved to Rickettsia spp.	25.00	25.00	150.20	150.10	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.16	0.72	-4.24	3	40	2009-01-15 18:05:59	2008-07-29 09:18:51	3	1	40	0	6	13	0	67.00	93	99.93	CHANGED	MQNPTQKVISFSEHKADIERIKKuIEEGWAIVKLVPNKDRFIGLLEKISHAE.DETIYIPPRKKIIVN	MQNPAQKVISFSEHKSDIERIKKSIEEGWAIVKLVPNpDRFIGLLEKISHAE.DETIYIPPRKKIIVN.	0	1	1	1
+10712	PF10880	DUF2673		Protein of unknown function (DUF2673)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Rickettsiae spp.	19.80	19.80	19.80	89.00	19.40	19.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.02	0.72	-3.93	3	42	2009-09-11 07:30:40	2008-07-29 09:21:59	3	2	42	0	6	19	3	64.20	87	78.54	CHANGED	MKNLLKILLILAFSAPVFASS...QlP.DPASVTTTQIpAMSTsDQQAWVASLTADQYNMLSPDVQKW	MKNLLKILLILAFASsVFASS..MQMP.sPASVTTTQIQAMSTDDQQAWVASLTAsQYNMLSPDVQKW....	1	1	1	1
+10713	PF10881	DUF2726		Protein of unknown function (DUF2726)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	24.70	24.70	24.80	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.28	0.71	-4.52	35	880	2012-10-11 20:44:46	2008-07-29 09:23:18	3	9	678	0	167	661	25	119.50	22	36.87	CHANGED	pc......tLhsssEpshhptLcpulss....ph.plhs+Vphu-llps......stpptppAhsphsu+phDFllsD.psh...pslssIELsss..sHp......psptppRDthhcpshcsAGlPllclphppshssspl+cpl.tsl	.................................................t...lhs.tpEtthhptL.phlsp.........ph.hlhs..pVphspllp...........ttpphhph.hp.h.hs.p.tp......hDaVlhc.t..psh.................pslssIELDss..p.Hh.............ptp..ptcRDthhpplhcpAGlPll.Rhp.pt.....p............hh......................................	0	45	92	132
+10714	PF10882	bPH_5	DUF2679;	Bacterial PH domain	Pollington J, Finn RD, Bateman A	anon	PRODOM	Domain	This family of proteins with unknown function appear to be related to bacterial PH domains. This family was formerly known as DUF2679.	22.30	22.30	22.30	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.93	0.72	-4.22	27	319	2012-10-04 00:02:25	2008-07-29 09:24:37	3	5	295	0	86	264	11	101.30	19	37.49	CHANGED	lcYtl-cpsLhI.pthhu..phpIPh.....spIpplphssshh..tsl+lhGhuthtahhGphh.hpchGpsphasTp.scphlhlcTss.psYsISPcsh-pFhppLcp+t	...........................................htlpsppl.l.ps.hs..phpIs.h.......spIp.s...l.........p.....h..h.s...sls.....tth..Rs...Gsu..ssthhhG.pFp..hp.shu.p....hhhh.sTp..spsllhl.c.Tc...c..psh...h..l....oscp.pt.........t.......................	0	36	71	81
+10715	PF10883	DUF2681		Protein of unknown function (DUF2681)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 81 and 117 amino acids in length.	27.20	27.20	27.20	28.30	26.30	27.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.91	0.72	-3.78	13	42	2009-12-08 16:02:13	2008-07-29 09:25:47	3	1	32	0	7	42	0	83.90	34	81.75	CHANGED	M.hslhlh.ussulhuslhualha+sc+upcc........tpLppEppQlpsEtpstpspVKNhcl+QKNEEss+phSpcsV.-pLppcG.hR.D	...........hshp.l.lhuhsulhshlhuYlha+lcptccc.......stpLhppNpQLpsEpsstpspVKpapl+pKN-EsspphuRssll-pLpppG.hR-.......	0	1	5	7
+10716	PF10884	DUF2683		Protein of unknown function (DUF2683)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Methanosarcinaceae.	22.80	22.80	25.00	24.70	21.80	21.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.69	0.72	-4.05	7	17	2009-01-15 18:05:59	2008-07-29 09:28:00	3	1	13	0	12	17	10	74.50	35	88.79	CHANGED	MVQAhlsIoDcoNpILsIlKAKYsLKDKStAI-hllppYpp.hLEP.EL+PEFlEchppIhc.cchl.lsol-sL+thhtt	...................MVps.lslsDcsNpIlpIhKApasl.cKS.AIshhlppapp.hhEs.El+PEFlcchpcl.KtpchIclsshcsLRccht.h...	0	2	4	6
+10717	PF10885	DUF2684		Protein of unknown function (DUF2684)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as yqgD however currently no function is known.	25.00	25.00	35.70	35.70	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.12	0.72	-4.12	2	241	2009-01-15 18:05:59	2008-07-29 09:29:20	3	1	239	0	7	33	0	76.70	77	95.94	CHANGED	hstDsThoLpVtsTGSLSVNpYGWINIWhAILGpFFsQFPhFFEuph.lhps.h..hsDNAsIhRIYhL.F.sllGhK......p++ss	........MstDsThoLpVpsTGSLSVNpYGWINIWMAILGQFFTpFPLFFESCLILLKTWLEIFPDNAGILRIYLLQFSAIVGYKT..........RRAA.......	0	1	1	2
+10718	PF10886	DUF2685		Protein of unknown function (DUF2685)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as uvdY.-2 which is an open reading frame within uvsY. However currently there is no known function.	25.00	25.00	31.50	31.30	23.00	21.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.65	0.72	-3.95	6	36	2009-01-15 18:05:59	2008-07-29 09:30:35	3	1	35	0	0	25	0	53.80	53	96.13	CHANGED	splCVVCKpPlccA.LuVcTspGsVHsG.CtpalpEhslSESs.....-p.LpETQLLh	...cICVVCKpPI-sA.LVV-T-pG.PVHPGsChsYlp-h..P....lS..ES.s.....-cpLsETQLLl	0	0	0	0
+10719	PF10887	DUF2686		Protein of unknown function (DUF2686)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as yjfZ however currently no function is known.	25.00	25.00	69.60	69.50	18.10	17.40	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.75	0.70	-5.67	3	406	2009-01-15 18:05:59	2008-07-29 09:32:52	3	1	257	0	2	128	0	263.10	67	99.79	CHANGED	MSMPLSNAhsoQasTsNHFLHHPpVDSElT+Ka.cYARhDLENIYL.PLsRGNNHNYDGKSsVEIRKLDISKpSW.PFNYVTssCREaDGITTTGRMLYRNLKITSALDEIYGGICKKAHAATELAEGLRLNLFMKSPFDPVEDYTVHEITLGPGCNVPGYAGTTIGYISTLPASQAKRWTNEQPRIDIYIDQIhTVTGVANSSGFALAALLNANIELGNDPIIGIEAYPGTAEIHSKMGYcVIPGDEDAPLKRMTLQPSSLPELFELKNGEWNYIGK	.......MohP.....po.h.hssah.HaspsDp.lphKa.phARhDpENIYL.PLsRGNNHNYDGKSVVEIRKLDISKps.W.PFNYlTpsC+E.DGITTTGRMLYRNL+ITosLDEIYGGICKKAHAuTELAcGLRLsLFMKuPF-PVEcYTVHEITLGPGCNVPuYAGTTIGYISTLPASQAKRWTN.EQPRIDIYIDQIhTVoGVANSSGFALAALLNANI-LGNDPIIGIEAYPGoAtIauthGYcVIPGDEDAslKRMTLpPSSLPELFELKNGEWNYltp........	0	2	2	2
+10720	PF10888	DUF2742		Protein of unknown function (DUF2742)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of phage proteins are the product of the gene phiRv1, however no function is known.	22.70	22.70	22.80	22.70	21.80	22.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.36	0.72	-4.06	4	68	2009-01-15 18:05:59	2008-07-29 09:33:11	3	2	51	0	7	28	0	93.70	67	74.31	CHANGED	ASRtVSWWsVHpaVtPhLstA..GsWPMAGTPAWstLDDsDPhKWAAlsDAucHWsLRVETsQpA.A-ASp-VSAAADWsuluRclpc+cshahtRshl	..............sSRtVSWWSVHEaVAPsLsAA...spWPMAGTPAWssLDDsDPhKW.AAICDAARHWALR..VETCQ.....sApA-ASRDVSAAA.DWPAluREI.pRRRssYItRssV.................	2	3	5	7
+10722	PF10890	DUF2741		Protein of unknown function (DUF2741)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as ubiquinol-cytochrome C reductase however this cannot be confirmed.	24.30	24.30	25.00	24.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.51	0.72	-3.84	4	42	2012-10-01 20:10:32	2008-07-29 09:36:22	3	2	24	0	29	45	0	69.90	60	74.83	CHANGED	MGKpPl+LKAVsYALSPapQKVMPGLWKDlsuKItHKVSENWluAsllhu.PlsGThpYA.aYpEpEKLcHRY	.........MGKt.PVRhKAVVYuLSPFQQKlMsGLWKDlPsKIHHKVoENWISAsLLls.PlVGTYpYst..apEpEKLpHRa........................	0	8	21	25
+10723	PF10891	DUF2719		Protein of unknown function (DUF2719)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Nucleopolyhedrovirus.	21.40	21.40	21.90	21.50	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.98	0.72	-4.30	5	33	2009-01-15 18:05:59	2008-07-29 09:37:14	3	1	32	0	0	27	0	74.40	32	83.87	CHANGED	MLRALKRRFKsAssEp+REED..VVLCPRCYFVAPGcISVADYTRMHIKFNEQFAD+CsNNFsVTQPKTWuNYoNCSALYYPL	..........................................cc..psp..VVhCs+ChFVAPhSlSaEEYlcLHcpFNphhsspC.........................h..t..................	0	0	0	0
+10724	PF10892	DUF2688		Protein of unknown function (DUF2688)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as KleB however currently no function is known.	25.00	25.00	25.00	59.10	24.70	17.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.00	0.72	-4.31	3	19	2009-01-15 18:05:59	2008-07-29 09:37:23	3	1	15	0	2	9	1	60.30	64	84.44	CHANGED	MsKGKIE..IVETsCRRCGKSIRTLSHSLIGAD-LREKLGGICG-CITPEEDpcITEuhLuA	..MsKGKIE..IlcTsCRRCGKSIRTLS+SlIGAD-hREKhGuICGsCITPEEDpclpEhhLtA.....	0	0	1	2
+10725	PF10893	DUF2724		Protein of unknown function (DUF2724)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteins with unknown function.	25.00	25.00	26.00	25.70	24.50	24.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.67	0.72	-4.11	4	172	2009-01-15 18:05:59	2008-07-29 09:38:01	3	1	164	0	8	86	0	64.50	68	94.77	CHANGED	MLpsEPSFASLLVKQSPuMHYGHGWIhscDGKRWHPC...+SQsELLtGLuTK+.tpp.........allKul+plpR	...MLTKEPSFASLLVKQSPA...M...H...a...GHGWIMGcDGKRWHPC...RSQDpLLAELSTKKpGp..........WLLKuhhRLF+.....................	0	0	2	6
+10726	PF10894	DUF2689		Protein of unknown function (DUF2689)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as TrbD however currently no function is known.	25.00	25.00	30.10	29.70	20.10	18.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.10	0.72	-4.19	4	128	2009-01-15 18:05:59	2008-07-29 09:38:19	3	2	101	0	2	84	0	58.30	79	62.49	CHANGED	MNMRNINlITAhSVPsKoVSDDFMHAVLSNCTTRIVLPAPKcFuSESLPHNFNMAAVGVMK	..MNMRNINVITAhSVPsKoVSDDFMHAVLSNCTTRIVLPAP+cFuSESLPaNFNMAAVGVMK.........	0	0	0	1
+10727	PF10895	DUF2715		Protein of unknown function (DUF2715)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Treponema pallidum.	21.70	21.70	22.10	23.10	21.30	21.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.21	0.71	-4.77	8	104	2009-01-15 18:05:59	2008-07-29 09:38:40	3	1	15	0	11	46	0	146.80	34	86.65	CHANGED	Chh......sshAupVFlSP+lGhsuhhhhGpsh.upthptst..p...........asPhlG.lsVulhAcNGhshssslDAuLTpLMFRuQsLlGYuhRhG..........................................shtalPsoGlsl....huop-ct........lhG......VPlpLshQaaFssahGl-sssouuVGlshp.sh.................................Dhpa......................................spa.........plPlolRlGPVFRl	..........................................................................shsspl.lSs+lG.ht.h.hG.ph.s.hh...........................sPhhG.lsluh.Ac.NGhhhthslDAuLTpLhFp.......upsLhGYuhR.G..........................................t..hhhs..hhsh....hspttt..............u......lslplthpahhsthhGlshshssuhsl.......................................s.th.............................tpa..........hhPhslplGPsFRh...................................................................................	0	11	11	11
+10728	PF10896	DUF2714		Protein of unknown function (DUF2714)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycoplasmataceae.	23.90	23.90	26.40	51.60	22.60	23.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.67	0.71	-4.39	7	55	2009-01-15 18:05:59	2008-07-29 09:39:24	3	1	52	0	16	37	0	145.60	37	85.27	CHANGED	spYcclhps.s....FlsYppLhspsLLcss.shpSs.hpcahcphh.Aatp+h-lVFcsFVIoashN.+FShstLlPhlstsEsSNo-uhN.hpssNsppapphLsp.aNphhp.pLhppp+hVElhPslIlFhuppTcpLKllFscphlhs	...pYc-hhssss....hloY-pLhuoVLLcsplGFpSclYpcFhp+hphAhcp+h-IhFcsFlIoFNlNLKFSsshLlP.lLsspEsSso-AlN.Fpss..ps.paspFLts.aNphIp.pLlpps+hVEIhP.slIlF+Spp.ssoLKllFScchl.o......	0	9	15	16
+10729	PF10897	DUF2713		Protein of unknown function (DUF2713)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	65.30	65.30	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.59	0.70	-5.12	3	258	2009-09-11 09:11:29	2008-07-29 09:40:13	3	1	235	0	1	98	0	209.60	84	88.19	CHANGED	VFLIEQINDLKMWVNKYIDDCTDEDLNDRDFIASVVDRAIFHFAINSICNPGDNKDATPIERCTFDVETKNGLPSTVQLFYEESKDNEPLANIHFQAIGSGFLTFVNACQEHDDNSLKLFASLLISLSYSSAYoDLAG..+VNINEYNENYLKAQFEELSQRDMKKYLGEMKRLADGGEMNFDGYLDKMSHLVNEGTL-PDILSKMRDAAPKLIDFAKSFDPNSKEKIKILTDTSKLIYDLFGVKSEK	..............................MWVNcYIsDCTDE-LNDR-FIASVVDRAIFHFAINSICNPtDNKDAo.IEpCTFDVETKNsLPSTVQLFYEESKDNEPLANIHhQAIGSGFLTFVNACQEHDDNSLKLFASLLISLSYSSAYsDLut..pV.INE.NEsYLpAQFEcLSQRDMKKYLGEMKRLADGGEMNFDGYLDKMSHLVNEGpL-PDILSKMRDAAPpLIsFAKSFDPsSKEcIKILTDTSKLIYDLFGVKSEK.............................	0	1	1	1
+10730	PF10898	DUF2716		Protein of unknown function (DUF2716)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.00	21.00	28.90	24.40	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.17	8	75	2009-01-15 18:05:59	2008-07-29 09:40:36	3	1	68	0	20	62	0	133.90	45	81.17	CHANGED	NWhtLScpEh-plW-+lYcca+F+..PuhStaPSh+sPsPalTaDlSshFsstuthss.....--lEpcsL+AFppsTtssEahhALDWQH-CYhlsP+lshp+D...EFs.EWhlPVaPNGDYYFFlpcDF+WGhLGHPWEpSITIFGc-LI	..............tWh.ho-pE.-plWsclasch.cFp..Pu..h..s..taP.uFchPs.PalT.a..clSph...h..sc.ss.hss........h--L-ccsLpsFpc.....sTss..sEahhALDWQH-CYhhsPHhph..p+s............EFs.EW.......l...PlF.PNGDYYFFlpcDFcWGhLGHPWEpoIolFGctLI...........	0	6	14	16
+10731	PF10899	DUF2743		Protein of unknown function (DUF2743)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	21.10	21.10	21.60	22.30	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.28	0.71	-4.92	9	148	2009-01-15 18:05:59	2008-07-29 09:41:27	3	2	147	0	18	78	0	120.60	50	33.97	CHANGED	pphh..pYssEchpa.h.s+pp.......lp.hshPMsCFsDIPLpclp.Hsp.....tYGpauIuhcKchulppshsPVhY....h.pss.hhpslhphhptl.s.........................................ptpspptl.psLthhhhhlKsa-ss..............pcsFYsE+EWRhlssh....t.....hh.cpp.....otpph..pt.hphp....+FsssDIcaIhls	............sSWSYRNGQRTVYGD..................................................SPVVCFTDMPIAAYLE.T.GVRRL..ERNEKIGLYAIVLPKEQM.FN..YGARPVIY.......GLDpHN.hp...............................................................................................................................................................................................suphppucph.c.hs...............................................................................	0	8	11	15
+10733	PF10901	DUF2690		Protein of unknown function (DUF2690)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	21.70	21.70	21.70	23.80	21.10	21.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.63	0.72	-4.03	6	208	2009-01-15 18:05:59	2008-07-29 09:43:39	3	5	124	0	29	142	0	109.60	43	54.09	CHANGED	pG+ShsGKsP.h.uCstsh.....s+hlsusshshuhVEL+aSsoCKTAWA+lT...s.s.s.cs.A.lhRsoDGKclss.uAGGsGch.....ssGpTssYTPMVhshDsRpuhAp	...............................tYDGKsPh.h..s.......oCDssuhs.....tcsphlsp......ss..........t...h......u.h.VELRaSssC+sAWAKlsl.....s.ssshss.A.....Ahl.......s+...ts..sGp.thos.sSsuGNGsl.........ppGQTS..sY..TsMVaDLss......................................................	0	9	22	27
+10734	PF10902	DUF2693		Protein of unknown function (DUF2693)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	21.40	21.40	21.40	21.70	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.70	0.72	-4.07	6	77	2009-01-15 18:05:59	2008-07-29 09:44:26	3	1	68	0	3	63	41	71.70	32	60.54	CHANGED	GpHpllFcKuDGolRsMhATRDshLl.spppGc.hh..sscsp..RKEscES....lsVYDlcscuWRSFplD+LISlsGhsltcLltl	............................phhapKsDGolRptpGThcsshhs..hppttp.........ts....p+cspss....lsaa.Dl-tpsWRoF+h-pLlsl...........h......	0	0	3	3
+10735	PF10903	DUF2691		Protein of unknown function (DUF2691)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.50	26.50	24.40	21.50	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.99	0.71	-4.39	9	107	2009-01-15 18:05:59	2008-07-29 09:49:18	3	1	92	0	9	81	0	144.00	44	95.65	CHANGED	pRGloF-IPNtYsphLhcILpsl-IssasW..l.ustEuYhltcGpL.scpLFscs.plhpGtsh+chlcss.YYlIFsDLKAaPpGchls-IpTYE-FhcScCElllLlsDusYVslYsKDpchlEhLYpNAhppuFppl-YITDENDsRTpLoV	...KRGIoh-I..Ps..p..Y..ssh.Lh..+lLKP.lcIs..s...a....sWh.l.sspEuYllhp.spL..sptLFsc-spl.h-Gp-L+cllK..sNhYYlI..FsDLKAaPKG....c..hl.....h-IpT.....YE..EFhcScCElVlLlsDupYlpIYsKspchIEhhYpNAhspGFh.V-YlTDENDsRTpLoV...........	0	2	6	7
+10736	PF10904	DUF2694		Protein of unknown function (DUF2694)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacterium spp.	20.90	20.90	20.90	21.50	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.25	0.72	-4.01	3	64	2009-01-15 18:05:59	2008-07-29 09:49:44	3	1	61	0	7	23	0	99.50	77	97.97	CHANGED	MTDANPAFDTVHPSGHILVRSCRGGYMHSVALSEuAMETDAETLAEGILLTADVSCLKALLEVR-EIVAAGHTPSAEVPTsRDLDVAIEKLLAHQLRRRs+	..............MTDANPAFDTVHPSGHILVRSCRGGYMHSVSLSEAAMETDAETLAEAILLTADVSCLKALLEVRNEIVAAGHTPS....AQVPTTDDLNVAIEKLLAHQLRRRNR.............	0	1	3	6
+10737	PF10905	DUF2695		Protein of unknown function (DUF2695)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	30.50	29.90	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.69	0.72	-4.24	6	82	2009-01-15 18:05:59	2008-07-29 09:50:16	3	1	77	0	8	46	3	53.30	52	46.29	CHANGED	Llsa.lsc+Lss.sCDHTh+auppahpp+plsh...csllchLtcpGGaCDCEllhN	........LhDY.VDE+Lu.cp.sCDHThRaupcahps++l-h...EolhEtLpEhGGYCDCEIlhN..	0	5	8	8
+10738	PF10906	DUF2697		Protein of unknown function (DUF2697)	Pollington J, Finn RD	anon	PRODOM	Family	This is a eukaryotic family of proteins with unknown function.	22.80	22.80	23.40	22.80	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.30	0.72	-3.97	9	39	2009-01-15 18:05:59	2008-07-29 09:50:42	3	1	38	0	29	37	0	66.00	40	78.69	CHANGED	EEWLYhKLlsSsuFppaVR+lasKlNtIp.pPh.cppss.sphh....Y+PTphpKFpAFRllaaDEhKpoF	.....EEWLYh+LlsSPuFHRFVR+lapKVNtI+.s..scps.ss..phl......a+PTt.hpKhpAaRhLFhDEh+ssh...........................	0	3	14	25
+10739	PF10907	DUF2749		Protein of unknown function (DUF2749)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins appear to come from the Trb operon however currently no function is known.	22.00	22.00	22.30	22.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.31	0.72	-4.10	8	39	2009-01-15 18:05:59	2008-07-29 09:50:55	3	1	18	0	15	40	1	58.90	40	41.19	CHANGED	MSptVlIALlls..VAuuuusATslIVpsc.......susssuhuEEQRssRE+FFGusp-.PPI+cGQEM+PRW	.....................................................................s...tt.ps+REpFFuus.c..-IRGGQcMcPRW.......	0	2	6	11
+10740	PF10908	DUF2778		Protein of unknown function (DUF2778)	Gunasekaran P, Mistry J	anon	Pfam-B_001575 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	24.10	24.10	24.20	24.90	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.82	0.71	-3.90	28	375	2009-01-15 18:05:59	2008-07-29 09:53:21	3	7	237	0	108	328	3	100.10	35	40.73	CHANGED	tpl-AaSGhGphhDcPctsslc.hGshPPusYhlh.R-u..........................................hhcGVc..AhRLpPl....................G.pGtSpGClohcshscFhphhcthchp.ph..ssVPuh	...........t..h.AaSG..st.hhspPp..hss.t.tGshPstp.Y.lh...Rps..............................................................hh.....pGVp..shRLpPs...................G.hG.SpGClohp.....shs.....pF.phhthh.hp.ph..shlst.......................................	0	19	44	70
+10741	PF10909	DUF2682		Protein of unknown function (DUF2682)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	24.80	24.80	24.90	90.40	21.80	24.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.61	0.72	-3.70	7	13	2009-01-15 18:05:59	2008-07-29 09:54:05	3	1	13	0	0	12	0	82.20	44	87.91	CHANGED	LhsVQcssLcLspEspsaLssssss..............pLEpcLhpLlhpsNsIsFD.....cppthp.LKsNlhsCINIhIDLIhIKphh	LltlQssVLDlh+ElspaLNsssPsh.........cthshL--hLTKhLhcuNAIsFD.....cppsLchl+sNIshCLNhhIsLITIK+Yl.	0	0	0	0
+10742	PF10910	DUF2744		Protein of unknown function (DUF2744)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	25.00	25.00	26.00	25.70	24.50	18.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.42	0.71	-4.30	6	89	2009-01-15 18:05:59	2008-07-29 09:54:53	3	1	88	0	4	50	1	133.50	44	89.78	CHANGED	ch.opEssDPscPEEtFlWsLpslPshsGssu......lhsssaL+thSKHLW-CGht.sD..............S.lPtQpl.KaQsPhRGppphhNssupWVshDsP-Pp.hRlpDstshTsQEppA.Lt.a+phGhl.st.s	....h.oQEcsD.ccPEEthAWAhh.s.LPtsu.G..ssu......lopPshhctWS+HLa-hGht.HsD.LcpLADEsGNIHVSpLPpQph.KaQsPhRGsRppa.NsA.ApWVspDsP-P..hRl.Ds+..pLTpQEppA.l.p..a+phGhI.s.......................................................	0	0	3	3
+10743	PF10911	DUF2717		Protein of unknown function (DUF2717)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as gene 6.5 protein however currently there is no known function.	25.00	25.00	29.70	29.30	19.90	18.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.68	0.72	-4.48	4	32	2009-01-15 18:05:59	2008-07-29 09:55:47	3	1	29	0	0	19	0	75.70	44	90.28	CHANGED	MLpPIp+hlpNPsDIPslPRAstEYLQVRaNtuYlhtSGhlstLRtsGaSEuaIAGFlpGLphA...SpslDEhE.lRKEQ	...........MLpPIpphhppPpDlPslPRustEYLQVcFNsuYhhtSGhlsth+ts.GhSEuaIhGFltGLtYA...SpllD-h-..hR+-.....	0	0	0	0
+10744	PF10912	DUF2700		Protein of unknown function (DUF2700)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Caenorhabditis elegans.	21.80	21.80	22.00	24.40	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.80	0.71	-4.20	6	52	2009-01-15 18:05:59	2008-07-29 09:57:19	3	4	5	0	52	47	0	136.20	22	65.64	CHANGED	lPARPLVssLulhGllRuhuphhhu.sshhpRlschhaLhLNLLLLFGAsKNstsALKWSQRlshhsVlLuVIpFMIaPVhFASasASG....h-pNtThh...clEplusKTp.Ec+..FVhGhLoGYslEFussLhIGlElLKYlLlNRLW	.................................hR.hlhhhuhhGlltshh...hhhs...ssh..h.t...h.....hs.hh..h..lhl..phllLaGshppsthsL+hupplshhsl..lls.hl.hhlhPVhhuShhASG............hpts..tsh.........p.....h..........s..t....ppp..........Fh.Ghh..Gh.hEhhhh................hhlsh.hhpahhlp.............................	1	8	11	52
+10745	PF10913	DUF2706		Protein of unknown function (DUF2706)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Rickettsia spp.	25.00	25.00	107.70	107.60	17.90	16.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.10	0.72	-4.37	2	39	2009-01-15 18:05:59	2008-07-29 09:59:14	3	1	39	0	4	15	0	58.70	90	99.87	CHANGED	MLK.hKhhllLIMLuQLLSCTPSAPYEIKSPCVus-IsDtuplshNPClRRPVNS.lsIs	MLKSLKhLLVLIMLAQLLSCTPSAPYEIKSPCVSADIDDGSSlSVNPCIRRPVNS.VNIV.	0	1	1	1
+10746	PF10914	DUF2781		Protein of unknown function (DUF2781)	Gunasekaran P, Mistry J	anon	Pfam-B_001738 (release 23.0)	Family	This is a eukaryotic family of uncharacterised proteins.  Some of the proteins in this family are annotated as membrane proteins.	21.20	21.20	21.30	21.20	20.90	21.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.98	0.71	-4.43	42	369	2009-01-15 18:05:59	2008-07-29 09:59:44	3	7	206	0	245	335	1	142.00	24	59.60	CHANGED	Dhlhhlaalhphshsh.....llDs..hhP....thh.t........htsltpaYlspapDhlh.....p.sPs.........ahpsh..................................hhhEhhaplPhhlhslY.................ulhps....sshhhshsLlauspsshophsplsphhh...............h.h..spctp..lltlYhPah.....llshlhslchhhpht	........................................................Dhhhhhahlhthshsl..................hhDh..h.hs..........lh.sh.........tpltphY.hpphpDhLhs.......sss...........ah+sh..................................hhhEhhapl.PhhhhuhY............................................ul..hts.........s.sah.shsllaustssp...sphspluthht...............hshthspc..tp..hlhsh.hsYh.....llPhllhhchhhp.......................................	0	57	107	171
+10747	PF10915	DUF2709		Protein of unknown function (DUF2709)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	23.00	23.00	25.00	386.50	21.20	22.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.39	0.70	-5.37	3	41	2009-01-15 18:05:59	2008-07-29 10:02:31	3	1	41	0	8	17	2	238.00	79	99.72	CHANGED	sVIosslKchLLQFLK+pKsAELLsTYLFFLEpKaQLQPVLFlRDKlIYQSAEDsIspLEcEGKLWRETEIpIusG+PuVNEpTKKIYICPFTGKVFGDNTHPNPQDAIYDWVSKCPENKERIuGlRVKRFFVSEDPEVIKoYI...KsRR-PIpKlVYSSuITGKLFsS+pAVIEDFK+SYLKsloLVEVQsQNKFKIEDsFLoFIQDpL-E-KIApFVEoLA-asEFcsYVcpWVEsE-	.MNISGSIKQKLLQFLcKQKuPELLATYLFYLEQuLpLsPVVFVRDKIIFKSsEDAIplLEtDKKIWRETEIQIoSGKPEVNEQTKRIYICPFTGKVFADNVYANPQDAIYDWLSSCPQNpERQSGVtVKRFLVSDDPEVI+sYI...VPPKEPIlKTVYASAlTGKLFHSLPsLlEDFcoSYLRPMTLEEVQNQNKFQLEoSFLoLLQDALEE-KIAEFVESLADDTAFHhYISQWVDTEE.	0	4	5	7
+10748	PF10916	DUF2712		Protein of unknown function (DUF2712)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillales.	21.70	21.70	21.80	22.50	19.40	21.60	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.93	0.71	-4.23	2	33	2009-09-10 14:58:50	2008-07-29 10:03:04	3	1	30	0	2	23	2	139.40	58	98.59	CHANGED	hppFhppNhRhlhAhslGl.lhAss.a.KAussNhtFchhl..shuNuhSsstaRpTopssNPWKVpLppSsEGKGTIhoFWL.h.stNpphspuSpIhNVKQGuts+YhtA.p.us+shshLAsENNNYsupoYhlDGlWDEETW	..............hppFhp+.hRLlhALVIGlLVF.APshH.SKAA..DNsIGFDFKLKPNCANSGSoSRYRETSSVNNPWKVRLcsSTEGKGTIASFWLGTYNKNKsAspGSsIMNVKQGAKT..RY.CGAYKVANKNTTYLAAENNNYNSKTYYVDGIWDEETW....	0	1	2	2
+10749	PF10917	DUF2708		Protein of unknown function (DUF2708)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Caenorhabditis elegans.	23.20	23.20	23.40	23.60	22.90	23.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.31	0.72	-4.16	6	26	2009-01-15 18:05:59	2008-07-29 10:04:11	3	2	5	0	26	18	0	43.70	55	53.18	CHANGED	MNhYSlFVFAlLuISuVo......ssG++Ct.GGNG.YGuG....VlIGAtK	...MNVYSVFl.FAlLAISSVS.......tG++Ct..GssG.YGuG.......s.....IlIGAtK.......	0	8	13	26
+10750	PF10918	DUF2718		Protein of unknown function (DUF2718)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function.	25.00	25.00	42.80	42.30	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.01	0.71	-4.11	4	13	2009-01-15 18:05:59	2008-07-29 10:04:30	3	1	12	0	0	8	0	124.50	54	96.89	CHANGED	MLCIFYLuRLCNLIIYSLYSLLMYPMpKLISFMFGELNPFc-VLPcscKKDD-ssl.........sIhPsEssslPpphP.plp-pt-pssls.pNs..................NGVFDFMKhPNPFKRY..YEYs.sYs.ppspspPp+Vp...cKuFlE+MlEMVE	MLCIFYlARLCNLIIYSlYSLLMaPMpKLISFMFGpLNPFsss.s.spKhpDshss..........htPh-sppIsp-hPLslh-ptppsshs..ss..................NGVFDFhKIPNPFK+Y..YEh....s.pNshKpPs.......KGhh-.MMphlE.....	0	0	0	0
+10752	PF10920	DUF2705		Protein of unknown function (DUF2705)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	46.40	45.90	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.79	0.70	-5.16	2	30	2009-01-15 18:05:59	2008-07-29 10:07:08	3	1	28	0	4	15	3	206.10	66	99.79	CHANGED	M+.pthhIhlVhhlF.tul...uas.shpshPhLDGhPluhus.h.hp.lLhWalPIluhSFhhSGsI+Dhh.SYt.LplsRpap+.hWlhpQFLhlhlhlllFT..QlAlhaIao.hShas.......st.FlhhhLhY.lhLhslFShQhhhELahcuQhA.L.IssYlIhSllhAchlhQ.sosph.aYhLlPNYu.GhRTGL..aopouThlIps.huLhIllll.lslhIlulhKFKphDhL	........MKNNKLIILVVIC..LFLQAILFMAFDFPFKTLPILDGFPVGLATPVVTRLLLYWYLPIIAFSFYISGNlKDLLSSYGFLQISRNaKKEYWLMKQFLKLhI+VILFTSLQLALIFIFTPYShas.......Tu.FlYLILGY.lMLFTIFSLQYLLELFIDAQKALLLINGYVIISILMADLIYQNTTVTWPYYLLLPNYGMGFRTGLI.FoNTSTlLIShPTSLIILLVVLLCVFIlAIKKFKTTDIL............	0	2	4	4
+10753	PF10921	DUF2710		Protein of unknown function (DUF2710)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Mycobacteriaceae.	26.20	26.20	26.20	27.40	23.60	26.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.26	0.72	-3.91	2	57	2009-01-15 18:05:59	2008-07-29 10:08:06	3	1	56	0	5	17	0	107.90	88	90.74	CHANGED	MVStssuRuE...LSD+DLVESVLR-LSEAADKWEALVsQAEsVTYSVDLGsV+AVANSDGRLLcLTLHPGVMTGYuHuELADRlNlAlsALR-EsEAENcARYGG.LQ	......MVSGSDSRSEPSQLSDRDLVESVLRDLSEAADKWEALVTQAETVTYSV..DLGDVRAVANSDGRLLELTLHPGVMTGYAHGELADRVNLAITALRDEVEAENRARYGGRLQ....	0	1	2	4
+10754	PF10922	DUF2745		Protein of unknown function (DUF2745)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	21.40	21.40	21.90	21.70	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.73	0.72	-4.07	4	21	2009-09-10 19:09:16	2008-07-29 10:09:42	3	1	18	0	0	15	0	87.50	50	98.76	CHANGED	MGRLYSGNLNAFKAAssRL.p.hDlsVhh--a.-phspppChp....LRlEDRuGpllsopTFpH+DEDVLaNhsTsWLN+hasQLKcWK	..MGRLYSGNLssFKsAssRLhc.hDl...sVhhEsap.ppsu+tChp....LRl.sRuGpll.sop..TFp..HpDEDVhhNhpT-WLp+haspLKcWK.	0	0	0	0
+10755	PF10923	DUF2791		P-loop Domain of unknown function (DUF2791)	Gunasekaran P, Mistry J	anon	Pfam-B_001611 (release 23.0)	Domain	This is a family of proteins found in archaea and bacteria. This domain contains a P-loop motif suggesting it binds to a nucleotide such as ATP.	22.20	22.20	22.20	22.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	417	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.91	0.70	-5.87	28	286	2012-10-05 12:31:09	2008-07-29 10:10:10	3	3	243	0	96	309	63	370.90	34	90.05	CHANGED	Ips+cRssllsuL+uGVVP+hGLchIsVGRspElpALhp-l-plusGGuuFRhllGEYGuGKTFFlphlRshAhc+saVsucsDLoP.-+RLHustGpuculYpcLhcsLoT+T+PcGsALpsIl-+Wlsslpc-shspu.............sssEplIcp+Lutls-hstGa-FAplLcuYa+uptpG-Epl+susl+WL+GEass+s-A+psLGV+slIDDsuhY-aLKhluthl+puGasGLllslDElVNLhKlpsstsRppNYEplLpllNDshQG+s.sLGhlhuGTPpFl.DsRRGlaSYtALpSRLupstas.psuhp-hpuPhIRLssLo.E-lhlLhp+lRclaAtststp....thlsDptlpsFhcpssuRlGuphhlTPRphl+cFl.slLsll-QNPshchpclhstst..hss-	...............................................................................................l..+.tpsllpuL+uGV.VP+h.GlthltVGRptElpuLhp.D.l..-.h.l.s.c.G..Gu.u.FRhllGcYGoGKoFhLphlRphAhc+shVs....scsDLoP...-R.RLpustspu....hshYpELhpNluT+...s...cP-G.s.......ALt.ll-+alsphppp..shtps..............................ttscphIhphl.spl..s-..h.st.Ga-FA.pllptYhc....u.....h.ps......c-ph+.st....sl+WlRGEhss+o-A+.....p...tLG...V.c.t.lIsD..s..sh.Y-hLKhhutFl+tuGYsGLllhlDEhV.N.l.a.K.......ls.......s..s.sRptNY..EplLphhN..DshQGp.spt.LshlhuGTPphl.......DtR+G.laSYpALps......RLupsp.......hs.....p.....sshh-h.uPsl+.L..t..sL.....o..sE-..hh.hLhp+ltclaAtt.s.p........hhls-pt.l.ttFhpttht+lGsth.hhTPRphl+sFl.plLsll.Qssshshpplhtt..h..t..........................................................................	0	40	67	83
+10756	PF10924	DUF2711		Protein of unknown function (DUF2711)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as ywbB however currently there is no known function.	21.20	21.20	23.20	26.20	20.20	20.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.47	0.70	-4.86	6	65	2009-09-10 23:06:20	2008-07-29 10:12:01	3	1	63	0	5	62	1	198.10	52	90.20	CHANGED	-cSPILtQLPpsFpSAAlLLHPFlpMPhGWEsuhRKpsYEHI.YPSsEEIlphG+sVSWpcVMossGLpShsELAlAlhTuIsA..LR-EYtRcDLAc+LasslctDLYYPoEDhTSlFLltsLLKVLGSKGAcslYYuEPIh-scGshpls-ssPhslhsLssuElIITDEphDaAFMSlaDSFoTLFLAK-psIccIlpuhshEAlICscsThIsWYh	............-cSPILpQlPtpapSAAILhpPFlQMP.GWEcuhRKpPYEHI.YPSsEEIIppGKuVSWKchMShoGL+SaA-LAhAh.hTSIuA..hp-EYpRcDLAE.+LasN..l.+.p.D.LYYPoED.aTShFLlppLLKlLGSKGucplYaS.EPIh-ssGlLplssToshD.lhDlu.ss.ELIITsEcp-aAFMSlYDSFsTLlLAK-cNIc.lVpuMNhEAlICDccThIsWY...............................................................	1	1	4	4
+10757	PF10925	DUF2680		Protein of unknown function (DUF2680)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as yckD however currently no function is known.	23.90	23.90	24.10	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.76	0.72	-4.10	14	166	2009-01-15 18:05:59	2008-07-29 10:13:36	3	4	89	0	53	148	1	60.30	27	44.87	CHANGED	LT-pQKp-IpsLtpQlh-lpKpllsKaVchGllTp-Qu-pIKppIDpthphh....cpN...........GFhP	..................tplpshppphhph+KphlsKhVctGhlTp-QA-pI+ppl-pphphh....pps...........sh...........................	0	30	43	50
+10758	PF10926	DUF2800		Protein of unknown function (DUF2800)	Gunasekaran P, Mistry J	anon	Pfam-B_001630 (release 23.0)	Family	This is a family of uncharacterised proteins found in bacteria and viruses. Some members of this family are annotated as being Phi APSE P51-like proteins.	19.80	19.80	19.80	19.80	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.37	0.70	-5.34	27	496	2012-10-11 20:44:46	2008-07-29 10:43:57	3	3	403	0	62	832	284	331.50	38	92.63	CHANGED	HAhLSsSuu+RWLpCPsSst.LppphsDpsSshAp.EGTsAHtluEhtL.............pptl.cshshhs..........hs.....................tt.hhs-EMt-hsptYl-hVhEphp.h.....sshlhlEQRlchuphlP-......uFGTuDslllu..ss...hLpIl.DhKYG+G.V.VsA...................ppNsQhhlYALGAlc.ashlYD.hcpVphsIhQPRh...cs.hSsap..lssp....-LhpWupphlcstAphA..............tspucapsGcaC.pFC+s+.ssCpARActshpls.ph-Fpsssh............................Losp-lup....lLsphs.lcpWsc-lcshAhpphhs.Gcph...sG..aKlVpGR.usR+as.D-csltpsLpstGhtpp.lYp.pcLlo.TphEKhh.....sc...........cpascll.tshlh+ssGKssLsspoD+RPul	....................................................................................................................HAhLSASuu++WLpCP..s...S........hp....h..p...p..t.h...s..-..p...s....S.....aA..t..EGThAHt.L...uEh..hl...................ptth...pt..st.h...............hs....................................................................p.thhs.c..E......M......t.....c......h..s.....c..t...Y.....s...s..h...V....-hh...pth........................sshhh..l...E...p....+..lDh..uc.aVsp....................uFGTuDslI.lu..........ss.......hLpIl..DLKYGpG...l....V..s..A...................t.pN..s...Q.hh..LY....A.L......G.....A.h.....c.....h....a....s..h.....l......Y.......D.......hcp........Vp......h....T.....I......h.....QP..Rh..............ss...hS.s.h.p...ls..hp.........c..L.h..p.W...upp..hlc...s..tAphA.................................htGpG..ca....ps......G...p...a..C..pFC+h+...sp...C+sRAch.hpls...p...ph.psPth......................................................Losp-luc.....lL.phstlppWsp-....lcpaA....h....s....pAhp....Gc.ph...sG....aK..L.V..EG..R.SpRtas...Dppsshp.h.l.h.p..sGa...cs...hhc....pcLlolTphEKLl......GK...........+tFsclh..tshI.KPpG..K.oLssp.oD+RPsh.................................................................................................	0	28	52	60
+10759	PF10927	DUF2738		Protein of unknown function (DUF2738)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	20.30	20.30	20.50	20.50	18.70	19.90	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.68	0.70	-5.32	6	39	2009-01-15 18:05:59	2008-07-29 10:44:37	3	2	27	0	12	40	35	219.30	26	63.81	CHANGED	ssshphp+hhFsKs.hascltsuH......RINl+Y-ccsshs..PLsh+TslLFSFGlpp.sshQDpsc.sYShsLsha-tp.GPospEptahshLpplts+s+cHL+c.sl++shs.....Kh.hssLhssMsshYhKhp-sls..........sPs+uPsLYPKllhut+ss.phsT..hFaKcscGpslpIs....llpp+C+Vlssltl-SIFlGsKsSlQlKlh-VllsE.........sls.p++plhhsphPss.ppE.p+csssssE--Lspp...tp.Ecl	..............................................s...................tss+......hlslpYcpp...t..PLhl..pss..hha.S.FGlps.s.....ohpsuss..saShsLhh..h.shp...s.sspEs.sFhpslctIts+s+cal.hc.s.+csht..........Kh......p.cslh-hh....p.....h.hhpp.t-sh...........sPscsPthYs...KLlhsppss.chhT...hhhp.sctptlch........hltt+spshsslth-Sl.a.h..s..sK.uhQhKL.psll..hE..........ht.............................................pt...........................................	0	12	12	12
+10760	PF10928	DUF2810		Protein of unknown function (DUF2810)	Gunasekaran P, Mistry J	anon	Pfam-B_001682 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	32.00	38.80	18.40	16.90	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.35	0.72	-4.23	12	654	2009-01-15 18:05:59	2008-07-29 10:46:18	3	2	649	1	55	192	7	53.90	79	45.01	CHANGED	plpsLsFsRslTKAEQADMGKLKKSV+GLVVVHPMTALGREhGlcpVTGaAP+t	......KLMcMPFpRAITKKEQADMGKLKKSVRGLVVVHPMTALGREMGLpEMTGFuKo.s.	0	3	12	34
+10761	PF10929	DUF2811		Protein of unknown function (DUF2811)	Gunasekaran P, Mistry J	anon	Pfam-B_001693 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	20.90	20.90	21.60	24.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.90	0.72	-3.96	31	108	2009-01-15 18:05:59	2008-07-29 10:46:54	3	2	64	0	50	111	199	58.20	47	69.16	CHANGED	ShpsElPEsLtpuMppFI-sHPsWDQYRlhpAALAsFLlQN.G........sssRsloRhYlssLF	..Sl.sElPEsLapuhpsal-sHPsWDQ.RlhsAALutFLlQN.G........ss..sRslsRlYLssLF..........	0	6	29	46
+10762	PF10930	DUF2737		Protein of unknown function (DUF2737)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	46.10	47.40	16.30	14.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.85	0.72	-4.36	5	174	2009-09-11 15:20:40	2008-07-29 10:47:25	3	1	162	0	1	62	0	54.20	81	99.29	CHANGED	M..RGLSYNPuILPoEhI...IR++hKPMPo..REELLKRNSFPSVNcNKYLNAMLRKs..KK	...MRGLAYNPGILPAEMI...IRQRsKPMPS..REELLKRpSFPSVNpNKYLNAMhRSG.KK....	0	0	0	1
+10763	PF10931	DUF2735		Protein of unknown function (DUF2735)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as glutamine synthetase translation inhibitor however this function can not be confirmed.	25.00	25.00	31.20	29.30	23.40	21.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.53	0.72	-3.72	11	50	2009-01-15 18:05:59	2008-07-29 10:47:42	3	1	50	0	27	53	0	51.00	37	76.29	CHANGED	SA+IYQFPl..GGRsGhsp+p...tth.spttssssssslssuSWYH--AlpE-ps	............SApIYQFPl..uuRtuhsppc...pst.spptuss.hssssssuuWYH--AlpEpp..	0	4	10	15
+10764	PF10932	DUF2783		Protein of unknown function (DUF2783)	Gunasekaran P, Mistry J	anon	Pfam-B_001590 (release 23.0)	Family	This is a bacterial family of uncharacterised protein.	19.80	19.80	20.00	22.60	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.81	0.72	-4.48	27	179	2009-01-15 18:05:59	2008-07-29 10:48:18	3	1	165	0	68	159	43	60.50	54	83.47	CHANGED	LspsPNlssP...........DsFYptLIssHcsLo--pSptlNARLILLLANHIGDhsVLpcAlphA+pu	..................LsTpsNl.scP...........DsFYEALI-sHRsLo-ppSphlNA+LlLLLANHIGDhsVL+EAlshARp.s..	0	10	32	49
+10765	PF10933	DUF2827		Protein of unknown function (DUF2827)	Gunasekaran P, Mistry J	anon	Pfam-B_001771 (release 23.0)	Family	This is a family of uncharacterised proteins found in Burkholderia.	25.00	25.00	25.40	25.30	21.20	23.60	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.19	0.70	-5.98	9	211	2009-01-15 18:05:59	2008-07-29 10:49:20	3	4	68	0	56	172	41	347.10	44	93.20	CHANGED	plGIolhl.RsssQSlW.NGItQNslaLshLLppSPhltcVslVNssDs.shssuL.hsthssslhshs-stcphDVlIEhuuQlss-ahchh+tRGsKlVohpsGs-YVhshEshhFs+s..shlFpsssYDplWslPpht+oshsaLpolhRuPVphVPalWcPhFl-pptpsL.ttG.tFGY+P.......G+.sthRlolhEPNIsVVKsslhPMLlu-pAYRtpP-hlcal+VsNoh+h.+-pPpFVthApuLDlVRcG+soF-uRashspFhApasDsVVSHpWENs.NYlYaDlLaGGYPLVHNSshLsDsGYYYPD.DspsGApsLh+AhpcHDsch-sYpp+uRshLtslsstsstNlutYsstLs	...................................lGIolhl.Rs.spulWtNGIpQNslaLshLLcpSshltcVhhVN.s.G..ss....sh..ssuL.hst.hsls.lhshs-s.hc.plDVlIEhuuQlss-ahpth+s+GsKlVshpsGp-YlhshEshlFs+ss..uplFsussaDtVWslPphtposhsaLpolhRuPVplVPalWsPhFl-+tttpL....t.tGhpFGYcP..........G+...tthRlohhEPNlsVVKoshhPMLls-EAYRtpPDhlpalaVsNoh+h.K-cssFVpF.s.p.sLDlV+puhsoF-sRashspFhApa.s.DsVVSHpWENs.NY.hYaDlLYGGYPLVHNSshLs..c..sGYYYPDFDstsGu+sLhcA.hccHDsph-sYpp+ucclLcplo.tNstNlstYsptl.h..........	0	14	17	36
+10766	PF10934	DUF2634		Protein of unknown function (DUF2634)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as phage related, xkdS however currently there is no known function.	31.80	31.80	32.00	32.00	31.60	31.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.25	0.71	-4.30	26	250	2009-09-11 16:39:40	2008-07-29 10:53:59	3	2	179	0	57	234	7	109.00	29	77.38	CHANGED	oYplcFppschhsp.......l-slEAl+QhlhhsLpT-Raca..IY....SpsYG.sElpsLIGp..hspshhcsElpRhlpEALlhcs+IpsVcsFph.phpsspl..plsFsVhTh.Gph	...................pathDhcps..chhtp..........l-sh.EAl+QhlhKsLpTcRac......a..IY........opsYG.sElp.c.LlGp...spshhcsElpRhIcEALhh-s..RIpsVssFph...ph.p...t...c.sl..plsFsVpohhGp...............................	0	27	49	51
+10767	PF10935	DUF2637		Protein of unknown function (DUF2637)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	22.80	22.80	23.10	22.90	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.94	0.71	-4.29	35	337	2009-01-15 18:05:59	2008-07-29 10:56:07	3	7	169	0	121	387	2	142.20	20	43.45	CHANGED	tsshshshslussuaslS.F..suL+clAhttu.hsst..hualhPlslDusllsuohhhlhh...tpssttt+hhsashhshu..........................................suhSlsuslhashhssts..pt...t.t.............hlthhhhhl....sPlthhssh+h......h.h.......hhtpshss	..................h.hshssshsluslAhslS..a.......suLpslAhp...tG...hssh..............huahhPlslDuslhssshhhlhh....ht....h..s.h...h...hh....phh.sWhh...h....ss..u..................................................sshs.lsusl..h.ashhhtth..ph......................hh.hhhh............ssh.hhh.h.....h....................t.t..........................................................................................................................................................................	0	33	90	114
+10768	PF10936	DUF2617		Protein of unknown function DUF2617	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.  	19.50	19.50	19.70	19.80	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.05	0.71	-4.68	15	185	2009-01-15 18:05:59	2008-07-29 10:57:39	3	1	180	0	42	119	0	142.50	39	95.31	CHANGED	hhppLsss.sDsuAusLuluLsusssssLAstclsh..ssuslpLsVLGASHtVslptss.uphsEpVuChssss....tsLPs.....psp.usGYchpopscslstucFpspAssLpscssccssuLsGsFPG-.stAlTALsAcss......ss..uhpW+TWHlY...Pps..GplVsT+S+hc...P	..............................hhpLths.sDspus.LuhsL.....s.t.s...sLAshcl...th.........sus..........tlpLsVLGASH.Vslct.........t...up...hsEpVuChstss.....ssLPt..................shp.s.t....Ychtuc.s...cshs.........ts.sFtthApcLht.......hs..s..c.....t.....st....hLsGsF.PGs....st...AlTAl...hup.p...............ts....thpW+TWHhYPpt...........GplVtTpoph......	0	12	29	39
+10769	PF10937	DUF2638		Protein of unknown function (DUF2638)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	22.00	22.00	22.10	22.00	21.00	21.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.73	0.71	-3.05	16	190	2009-01-15 18:05:59	2008-07-29 10:58:45	3	5	164	0	134	177	0	92.30	28	77.69	CHANGED	sPhI+FlGpRp..sppsspsstsHPsossshlP.........suhuuappphppasPhp......pss..tu..ustsuuuhusl......pPhp.GEhhshs-LPsRF+.ppPhsEAElEuIpoG.GA	...........................................................................I+FhG....................t..tts...sHPhsss.t.hs.................t.h..h.....h.t...P................t................tth.us.ps.uss.sss....................pshp..sphhsht-LPtRF+...R...ps...h..sptElEsIpoGGs..........	0	35	67	108
+10770	PF10938	YfdX		YfdX protein	Bateman A	anon	Bateman A	Family	YfdX is a protein found in Proteobacteria of unknown function. The protein coding for this gene is regulated by EvgA in E. coli [1].	22.60	22.60	23.00	23.40	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.98	0.71	-4.56	23	564	2009-01-15 18:05:59	2008-07-29 11:02:18	3	2	501	4	62	218	7	153.00	55	68.75	CHANGED	pAlpclppAttAlps.GpscpAhptlpcApuplchhtsc.sphs...t...................................hlPVsspltlh-t.hssssptcsulppApptlppGchptAhchLchhss-lshshshlPLsph.sulppAtpLLcpsKhpEAstsLptAh.solVlsp.shs	.................................AMRDlQhARhALFc.GDs-..KAKcLss-AouLLsDDST-WsKFAKssKKsslssD...........................pYIsINuSlsluEs.Y....ls..TPEKcAAIchANEKMs+GDKKGAhEpL+LAGVuVhENQhLhPLcQTRsAlscAp+LLDcppYYEAsLALKuAc.DGIIVDSpu..l......................	1	20	43	52
+10771	PF10939	DUF2631		Protein of unknown function (DUF2631)   	Pollington J, Finn RD	anon	PRODOM	Family	This is s bacterial family of proteins with unknown function.	25.00	25.00	28.30	27.90	18.00	16.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.25	0.72	-4.13	13	179	2009-01-15 18:05:59	2008-07-29 11:51:58	3	1	177	0	44	115	0	66.90	47	58.98	CHANGED	hAuTElEhasG.......VDst-VPSAsWGWSphshRshpIuGlluuhFLLsMlhGNHpG........+VEDhaLIGF.AA	...................tsptsEhasG.................V-.T......t-sPSAAWG..Wpp.....lspRshpIsGhhssh.FLLuM.l.hGNHpG........HVEslaLlsFAs.........	0	11	33	41
+10772	PF10940	DUF2618		Protein of unknown function (DUF2618)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function. The sequences within the family are highly conserved.	25.00	25.00	35.90	35.50	18.40	16.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.16	0.72	-4.18	3	84	2009-01-15 18:05:59	2008-07-29 11:52:30	3	1	84	0	9	19	0	34.40	68	89.18	CHANGED	KGRSIMAHIRRTRHIMMPSYRSCFSYSlFsSQ.SoSHhAL	.......ts+IMAHIRRTRHIMMPSHRshFDaSFFst.........h.....	0	2	2	5
+10773	PF10941	DUF2620		Protein of unknown function DUF2620	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	25.00	25.00	35.00	43.10	23.90	23.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.41	0.71	-4.06	12	324	2009-01-15 18:05:59	2008-07-29 11:54:02	3	1	316	0	27	96	0	113.90	80	97.87	CHANGED	h+IsIGGtlpKcpIcchlcch.ussphpshlhuDh-AAMtVKsGphDYYlGACpTGuGGALAMAIAllGhs+ssTIuhPut.spcEcIcphVspGKhAFGFTs-HhEpAlshLlshLh	...KKIGVAG.LQREQIKKTIEAT.APGsF.E.VFIHNDMEAAMKVKSGQLDYYIGACNTGAGAALS.......IAIAVIGYNKSCTIAKPG.IKAKDEHIAKMIAEGK.VAFGLSVEHVEHAIPMLINHLK.....	0	7	12	21
+10774	PF10942	DUF2619		Protein of unknown function (DUF2619)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	55.20	55.00	19.60	17.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-8.91	0.72	-4.03	15	172	2009-01-15 18:05:59	2008-07-29 11:56:57	3	1	170	0	42	92	0	69.00	58	71.95	CHANGED	RlLSusIEloAAlLML+hNDlcKAltINulLAlVGPsIhIlohoIGLhulAu+lShsKLlhIhhGVsLI	RLhSGShEIhAALLMLhlNDs+KALhINuhL.AhVGPTVLIlTMTIGIsulA.uclSahKLhalslGlsCI.	0	19	34	37
+10775	PF10943	DUF2632		Protein of unknown function (DUF2632)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of membrane proteins with unknown function.	25.00	25.00	290.30	290.10	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.52	0.70	-4.85	2	43	2009-01-15 18:05:59	2008-07-29 11:58:42	3	1	4	0	0	24	0	180.40	93	100.00	CHANGED	MF-TNaWPFPDQAPsPFpAQl-pLouTENVYIFLTTLFGILQLVYVhFKLLCTMFPoLHFSPIWRGLENFWLFLSLsSLAIAYWWLPSMTFTGYWALTlIATILVhlhLIMMFVKFlNFVKLFYRTGSFAIAIRGPIVLVALDVTIKLHCTPFAILVKElGsIFYLSEYCNKPLsAAQIAAL+ICVNGQWFAYTRSSTTSAA+VAAANSTAKYHLFlLQGVA-YTQLSSVKFE	......................EQLSSTENVYIFLTTLFGILQLVYVhFKLLCTMFPsLHaSPIWRGLENFWLFLSLsSLAIAYWWLPSMTFTGYWALTlIATILVLlMLIMMFVKFlsFVpLFYRTGSFAIAIRGPIVLVALDVTIKLHCTPFAILVKEVGNIFYLSEYCNKPLsAAQlAAL+ICV.................................................	0	0	0	0
+10776	PF10944	DUF2630		Protein of unknown function (DUF2630)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins have no known function.	21.10	21.10	21.20	21.20	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.86	0.72	-3.88	14	143	2009-01-15 18:05:59	2008-07-29 11:59:06	3	2	141	0	52	97	1	79.40	54	94.45	CHANGED	ssDp-ILsplpcLVsEE+cLRpphppGcIDpupE+p.RLpplEspLDQCWDLLRQRRAhRsuGpDPD-ApsRPsspVEsYhp	.....s.sDp-hLu+Ic-LVAEE+tLRuphppGtIspsEE.pp.RLRclElcLDQCWDLLRQRRAhRpsGsDPc-AtVRPsspVEGYp........	0	15	37	49
+10777	PF10945	DUF2629		Protein of unknown function (DUF2629)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as yhjR however currently no function is known.	20.80	20.80	20.90	22.50	18.90	20.40	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.32	0.72	-4.61	7	472	2009-01-15 18:05:59	2008-07-29 11:59:37	3	1	469	0	27	83	0	43.90	84	69.07	CHANGED	phQsDhhALSQAFSLP-lsYtDISppEpLstAltRWPLLAEhAc	...............h.FQNDIlALKQAFSLP-IDYADISQREQLAAALKRWPLLAEFAQ..	1	3	6	17
+10778	PF10946	DUF2625		Protein of unknown function DUF2625	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as ybfG however currently no function is known.	19.90	19.90	20.50	20.10	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.29	0.70	-5.39	12	157	2009-01-15 18:05:59	2008-07-29 12:00:21	3	1	150	0	24	112	2	191.50	47	90.87	CHANGED	Lc-Llshc-sAWsllp-WhspApN+hElLss.sspAppsLhsLQVoTRSshGAllYpoGGllIDtGWLRlLGSGp.+LsRslssWNtG+.tht..hptssaLLlADDslGGaFAlNGGuLG.....-csGplYYaAPDoLpWEsLplGYS-FLtWslsscLscFYcsLRWpsWps-VtpLsucps.asFhPhLWspps...slctpS+csVslpEha	........hppLls.-cSAW.llppWlpsApN+sElLsss.ps.tA.c.psLhphQloT+SPMGAllYpoGGlLIDpGWLRIhG..SGp.+.LP...Rshhs...WN.t....pFs......tsphLllADDVhGGhFAlNG.....GsLG.....ccsGplYYauPDoLpWEsLpluYSEFLtWALsGDL-sFYpslRWpsWp-DVtpLsusps.asFhP.La.ppt.....-tpp+p.lslppha....................	1	7	15	23
+10779	PF10947	DUF2628		Protein of unknown function (DUF2628)    	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as yigF however currently no function is known.	22.80	22.80	22.80	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.68	0.72	-4.25	71	909	2009-01-15 18:05:59	2008-07-29 12:40:52	3	16	750	0	179	662	139	105.40	19	55.47	CHANGED	hshashhp....sts..............ttts................ththlp.pG..........asa..hAahF..uhh.........ahhhp+hW....hhs.hshlslslshslhhhhh............s.shhh..................hltlhl....slhhGhpusth...hhhcht+	...........................................................................................pt.....................ththhc..u...................asa..hAhhF..shh.........ahhh++h..W............hhu...hhhhhl.sl.shs.l..lshhht.......................hhh..............................................................hltlhl....tlhhuh.uNth....ahpph....................................................	0	41	96	128
+10780	PF10948	DUF2635		Protein of unknown function (DUF2635)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of phage proteins with unknown function.	20.10	20.10	20.40	20.10	19.70	19.70	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.29	0.72	-4.66	20	259	2009-01-15 18:05:59	2008-07-29 12:43:16	3	1	235	0	33	149	2	46.20	45	73.56	CHANGED	lKPAp.G....hsV+DPptGchLss-GcpVscsu.aWhRRLpDGDVlhspsps	.........................lKPst..G......+sV.DP....sp........uchL..PsEGc...pVscss.aWhRRhssGDlhplspp.s....	0	4	11	25
+10781	PF10949	DUF2777		Protein of unknown function (DUF2777)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Bacillus cereus.	25.00	25.00	69.00	68.20	22.20	18.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-10.88	0.71	-4.61	10	135	2009-01-15 18:05:59	2008-07-29 12:51:55	3	1	134	0	21	80	0	182.20	56	96.18	CHANGED	Ms....pR..pphLhppsRpashGTl.hIc-pasFh--EEs-thLlEslspsslElhcsscWppuphh.-pshlppusEphsLpsGEpIRhcKpLthuhhpLLs-LsDssFhtFlspLpSLGaSlYDClaCaNtLsF.......spppsspGVNFlpFsN--tlCulQHHasRtpsps......DRFEaTtusGcRhlhpps	..............M...hQR..KHILYNQPRAHTlGNVEYINNEWlFF.DDEN-EAFLLE-IAEDGFEILYNNNWLPARFY.EQslL.QIAsEQHpLQNGEMIRIRKKLLLSYpEWLEELPDSlFsLLTEsLQSL+YSLYDChYCHNaLSFL......PcEEssEGVNlLLFDN-EMICoLQHHFVR+soSNK.....NhFcFTKsNGEcLHI-u.T...	0	4	13	15
+10782	PF10950	DUF2775		Protein of unknown function (DUF2775)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	22.50	22.50	25.40	22.70	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.09	0.72	-10.75	0.72	-3.83	8	136	2009-01-15 18:05:59	2008-07-29 12:54:08	3	9	11	0	35	126	0	76.40	38	100.80	CHANGED	pDlt.YW+hlMKDpDMPEtIpuLLs.p......phcs.pph..t..........pctulc-FEPRPpho..sYssN-lchpEKKpslc-FEP+PNlSAYGDN-IctpEK.KsslpDFEPRPNlSAYs	...................................................................................pph-sh....sslo...tYs-spl.cspp.ppp..hscDFEPRPNlotY.sDt..hchcpp.pshs............cDFEPRPslotYs..................	0	0	31	35
+10783	PF10951	DUF2776		Protein of unknown function (DUF2776)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.90	20.90	21.10	83.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.46	0.70	-5.39	7	355	2009-01-15 18:05:59	2008-07-29 12:55:53	3	1	344	0	11	142	0	329.40	81	98.46	CHANGED	MNYGISlLFRAIPLlMulhChuYGuFlhp.Gss..usthVAG.VlhSLuhICIALFsTAATIIRQlI+sYNphhpahLPllGYLuAslThlhGhsh.hspusssusFVAGHVlhGVGhIsACVATsAsuSTRFoLIPtNucss.ssthPtsAFopttuhhLIslsllholluaIWuahLLuco-ppss.aVAGHVhhGLAsICsSLIALVATIsRQlRNsaoc+ERhhWsthVllMGSIolLhGlaVL.usosssphusGYIhIGLGLVCYSISSKVlLLAtlWR+chKLANRIPLIPVhTALACLFLuAFLhEhusscssYFIPARVLsGLGAICFTLFSIVSILESGTS	......MNIYIGWLFKLIPLlMGLICIALGGFVLESSGQ..SEYFVAGHVLISLAAICLALFTTAFIIISQLTRGVNTFYNTLFPIIGYAGSIITMIWGWALLAGNDVMADEFVAGHVIFGVGMIAACVSTVAASSGHFLLIPKNAAGSKSDGTPVQAYSSLIGNCLIAVPVLLTLLGFIWSITLLRSADITPH.YVAGHVLLGLTAICACLIGLVATIVHQTRNTFSoKEHWLWCYWVIhLGSITVLQGIYVLVSSDASARLAPGIILICLGMICYSIFSKVWLLALVWRRTCSLANRIPMIPVFTCLFCLFLASFLAEMAQTDMGYFIPSRVLVGLGAVCFTLFSIVSILEAGSA.........	2	5	7	9
+10784	PF10952	DUF2753		Protein of unknown function (DUF2753)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	27.10	27.10	27.10	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.88	0.71	-4.19	7	99	2009-09-11 03:22:03	2008-07-29 13:02:31	3	2	99	0	15	59	2	134.70	69	95.28	CHANGED	WE+HTLLA-pAhppss.htoIlHYQ.ALu.Sppl...psspt-L-DhlslpVlSCHNLApFWRttGDscYELKYLQLASEpVhsLlPQCPpppC-uFlsoLGCCpuALl-FhKRHPNPtIA+plpcIsosspCELIApF+Lp	....................................WE+HTLLADhAhQ-sDHLRSILHYQQALTlSppl..sEu-EI-hEDRhhISVISCHNhApFWRshGDspYELKYLQLASE+VLTLIPQ...C.pssCEAFlDSLGCC+KALlDFMKRHPNPcIA+hVQ+IDTAopCElIApFRLN..............................	0	1	4	8
+10785	PF10953	DUF2754		Protein of unknown function (DUF2754)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Enterobacteriaceae.	25.00	25.00	91.90	91.80	24.10	19.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.57	0.72	-3.92	3	443	2009-01-15 18:05:59	2008-07-29 13:05:01	3	1	440	0	15	74	1	70.00	90	92.22	CHANGED	MpLosKIRRDWHYYAVALGLIFILNGVVGLLGFEAKGWQTYAVGLVTWVISFWIAGFIIRRRPEEopsAE	MNLPVKIRRDWHYYAFAIGLIFILNGVVGLLGFEAKGWQTYAVGLVTWVISFWLAGLIIRRRDEETENAQ.......	0	1	1	8
+10786	PF10954	DUF2755		Protein of unknown function (DUF2755)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated as YaiY however no function is known. The family appears to be restricted to Enterobacteriaceae.	25.00	25.00	90.60	90.60	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.33	0.72	-4.29	6	443	2009-01-15 18:05:59	2008-07-29 13:09:54	3	1	440	0	15	59	2	100.70	89	98.89	CHANGED	MADFTLSKSLFuGK.RssSSTPGNIAYALFVLFCFWAGAQLLNlLVHAPGVYE+LMQsQ-TGRPRV-IGLGVGTIFGLlPFLsGClIhuVlAlhLRWR+R+	............MADFTLSKS.LFS.GKYRNASSTPGNIAYALFVLFCFWAGAQLLNLLVHAPGVYERLMQ..VQETGRPRVEIGLGVGTIFGLIPFLVGCLIFAVVALWLHWRHRR.	0	1	1	8
+10787	PF10955	DUF2757		Protein of unknown function (DUF2757)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as YabK however currently no function is known.	22.50	22.50	23.10	34.70	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.75	0.72	-3.79	8	173	2009-01-15 18:05:59	2008-07-29 13:10:27	3	1	173	0	32	85	1	72.70	56	99.25	CHANGED	MAlaYaCRHCGhcVGoLspsslpo.-pLGFacLT-cE+sDMIoYcpNGDlHVKTICEDCQEuLpcNP-YHpacpFIQ	.....MthaYYCRHCGspVGSlsu..pp....Vho.-sL..apLTEpEhs-MIpa+E.NGs.I.alKTICEpCQEsLss.PEYaEY-pFlQ..........	0	10	22	24
+10788	PF10956	DUF2756		Protein of unknown function (DUF2756)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins are annotated yhhA however currently no function is known. The family appears to be restricted to Enterobacteriaceae.	20.70	20.70	21.40	31.10	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.61	0.72	-3.78	5	476	2009-01-15 18:05:59	2008-07-29 13:14:17	3	2	469	0	27	111	1	101.90	81	74.37	CHANGED	MKRLLlLAALLPFuuLAQPINThNNPNQPGYQIPSQQRMQTQMQTQQlQQKGMLNQQLpTQTRLQQQHLQoQlNNNsQRVQQGQPGphN.sRQQVLPNTNGGMLs	.......MKR.LLl.LTALLPF...VG...FA..QPINTLNNPNQPGYQ..IPSQQRMQTQMQTQQIQQKGMLNQQLKTQTQLQQQHLENQINNNSQRVLQSQPGERNPARQQMLPN.TNGGMLN........	0	1	3	15
+10789	PF10957	DUF2758		Protein of unknown function (DUF2758)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	20.50	20.50	20.60	20.60	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.93	0.72	-4.15	7	170	2009-09-11 11:48:29	2008-07-29 13:15:39	3	1	166	0	16	74	3	59.30	56	94.78	CHANGED	MlKVtVFDcEHEKDLpp-lNpFLKplc-spllDIKYsVAAh.p-s-tEQlYCFSAhIlY+p	..............Ml+VKVF..DEpH.E...K...DL..E...DAVNsFL.KK.IcDs..phVDIKYQ..Vuso...hss...--sQIY.CF.SAMIlY+s.................	1	1	8	10
+10790	PF10958	DUF2759		Protein of unknown function (DUF2759)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillaceae.	20.70	20.70	21.30	23.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.57	0.72	-4.38	11	150	2009-01-15 18:05:59	2008-07-29 13:16:40	3	1	147	0	29	71	0	51.80	62	84.06	CHANGED	IFuLVolLAlaGslRuLKcKNlLullFuuuohhVFGWFoIMTllasGaP.ssH	.......IFsLV.TLLAVFATLRTL..RE..KNhLAsGFAlATVLVFGWFTIMTVLasGYP.sA.s........	0	8	20	23
+10791	PF10959	DUF2761		Protein of unknown function (DUF2761)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as KleF however no function is known.	25.00	25.00	26.40	92.20	20.20	19.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.07	0.72	-4.36	5	34	2009-01-15 18:05:59	2008-07-29 13:22:50	3	1	21	0	4	19	1	92.10	78	70.28	CHANGED	PYPPGFVCPsTGRVAVLVRDYAsSDLNGDAPAYWYSAQSEEWGLDPWRLVEGVDPHTpGGSaDVCFAsGSoRTVGPLMTFFL..uAuDAARLsA+cGc	.PYPPGFVEPoTGRVAVLVR-YAsSDLNGDAPAYWYSAQSEEWGLDPWRLVEGVDPHstGGSFDVCFAsGuoRTVGPLMTFFL..SAucAApLsstc.s...	0	0	1	3
+10792	PF10960	DUF2762		Protein of unknown function (DUF2762)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as holin-like protein BhlA however this cannot be confirmed.	22.60	22.60	22.90	22.70	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.44	0.72	-4.27	14	187	2009-01-15 18:05:59	2008-07-29 13:23:53	3	1	139	0	26	134	0	71.30	32	92.17	CHANGED	M.Ep-llplhhoQGhaAlLFshLLFYlLKpsc......................EREp+YQplIpc....lT-pLshlpshtccVp-hhp+	...................tlhphhhoQGsaAsL...FlhLLF....alhKpsc..........................cREc+hQphI-+....hs.-phpslp....c....hhp-lpch.t...............................	0	11	24	26
+10793	PF10961	DUF2763		Protein of unknown function (DUF2763)	Pollington J, Finn RD	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	21.60	21.60	21.90	22.30	21.10	21.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.16	0.72	-3.59	10	138	2009-09-10 16:34:48	2008-07-29 13:24:32	3	3	107	0	90	143	0	89.80	34	86.04	CHANGED	VYlSs.GsVh-.ppRSPWRLShlsDFFhGllsFIshFFpTlls.ssscstppssuusp+ascGtGssGsssGtpthGpIs+GuGPsssP..hGG	......................sYlsp.GpVh-....pposWRLuhIsDhFaGIhpFlhhF.FpTlls..............ssscp......tp.h.s.s.......s..s.sp.....c....a.....s.s.....Gt..Gs....sG.s.....s........stthGths.th..tGst......................................	0	27	43	67
+10794	PF10962	DUF2764		Protein of unknown function (DUF2764)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	20.50	20.50	20.90	20.50	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.56	0.70	-5.17	10	168	2009-01-15 18:05:59	2008-07-29 13:25:16	3	2	164	0	42	131	10	218.90	28	88.05	CHANGED	MopYYaLluGLPslslEDsKLsYols-FcsELtssLSccDpKLIDLhhhcFDNtNlLtahcss-stscscGp...lop-Elsshlush+-u-....sscaPsYFp-FlppYht..................psucEp......lsaEDcLuAhYYsYAMcsuNcFlpsWFpFNLslpNILsAhsuRKhphDlu.hl....VGcs-Vs-sLRTSsARDFsLu-ElshLpsllcluEcp-lslREKpLDll+WcWlE-ss.F.cYFslEplhAaLLpLtMIERWlpLDKc+GpphFRcIIsslK+ul	........................................................sp.YYhL.uhLs..t.-s..l.aohtphps.lh.thotpD.p.hslhhh.hD.tN.hthh..httcs......u...............hs.ppl.thht....t.t...........th.sah.pFl.ta.......................spp..............h...stLht.ahta.h.p..tspFlpsaapFp.slpslLsuhpuRhht.h...D...hu....l....su.ss.lhphLhpp.su..satLst.p.h..lppl....hp...tppsh..ht.....EcpLshhcW....phlE-hs.hhcYFsh-tlhuallpLthlpRhhphcp-+Gtp.F+pllpphcpt................	1	17	30	35
+10795	PF10963	DUF2765		Protein of unknown function (DUF2765)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	25.00	25.00	25.50	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.52	0.72	-4.03	23	119	2009-01-15 18:05:59	2008-07-29 13:28:37	3	1	113	0	21	93	0	81.90	40	88.01	CHANGED	IsLslsG..sDhpFssTsssYNcalNshspssKVsPA.+NaLhpsVcsEpK-sLccLl....psPGu..shplsutlhcEasPclpIsVKc	..................IsLslsG..s-lsF.pPs.suYNpalN-hshsNKVuPA.+sYLhRhVs.s.EsK-ALpcll....chPGs..uhQlsupVs-.YuPcl-IpVKp...........	0	4	11	14
+10796	PF10964	DUF2766		Protein of unknown function (DUF2766)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	21.20	21.20	21.30	86.00	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.66	0.72	-4.09	3	372	2009-01-15 18:05:59	2008-07-29 13:29:13	3	1	371	0	20	76	0	78.70	90	95.56	CHANGED	MScPLNsDQELVSDLVACQLVIKQILDVIDVIAPsEVRDKMSSQLKNIDFoTHPAAADPVTRRAIEKAIALIEMKF...TPp	MSQPLNADQELVSDVVACQLVIKQILDVLDVIAPVEVREKMSSQLKNIDFTsHPAAADPVTMRAIQKAIALIELKF...TPQ...	0	1	6	12
+10797	PF10965	DUF2767		Protein of unknown function (DUF2767)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	20.70	20.70	20.80	21.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.27	0.72	-4.13	4	459	2009-01-15 18:05:59	2008-07-29 13:29:51	3	1	445	0	22	84	1	64.50	87	98.89	CHANGED	MGNcsK--tLYQEMCRVVGKVVLEMRDLGQEPKHIVIAGVLRTuLANp+IpRStLphQAMEpVI+uLst	.........Msp.sK.-D-LYpEMCRVVGKVVLEMRDLGQEPKHIVIAGVL.RTALANKRIQRSELE...KQAMETVINALVK......	0	1	1	13
+10798	PF10966	DUF2768		Protein of unknown function (DUF2768)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appear to be restricted to Bacillus spp.	20.00	20.00	22.20	22.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.73	0.72	-3.83	11	157	2009-01-15 18:05:59	2008-07-29 13:30:25	3	1	157	0	28	87	0	57.20	58	86.96	CHANGED	KMWhulGuMGhMFluVssIYLSRaKlps+FL+hlsuhlAYhhMllSGlIlhhVVhSGP	KMWhALGAIGFMFhAVuhIhLSRaKlKNKaLKuIsALVAYsLM.IVSGIlIFlVVFSGP..........	1	9	19	22
+10799	PF10967	DUF2769		Protein of unknown function (DUF2769)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins have no known function.	20.70	20.70	23.30	21.20	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.90	0.72	-3.67	16	59	2009-01-15 18:05:59	2008-07-29 13:34:54	3	3	24	\N	52	56	1	55.10	30	45.26	CHANGED	Ch..CssCPSastp.....tsctlFChpGpSptphhpc..GChCsp.CsVhpphpLpst.YYCh	..........Ch..C...Csoas.p..........................t.ttlaCspG.p.S.p.sphppcp.sChCss.CsVapc..a..pLpps....YaC.........	0	12	31	43
+10800	PF10968	DUF2770		Protein of unknown function (DUF2770)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as yceO however currently no function is known.	25.00	25.00	34.60	34.40	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.54	0.72	-4.28	6	426	2009-01-15 18:05:59	2008-07-29 13:36:04	3	1	421	0	15	52	0	36.00	77	92.93	CHANGED	MRRLhshLlNNlREHhMLYlhLWhLLAllDllalaa	.MRRLLHYLINNIREHLMLYLFLWGLLAIMDLIYVFY	0	1	3	10
+10801	PF10969	DUF2771		Protein of unknown function (DUF2771)	Pollington J, Finn RD	anon	PRODOM	Family	This bacterial family of proteins has no known function.	25.00	25.00	28.00	27.70	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.08	0.71	-4.96	13	173	2009-01-15 18:05:59	2008-07-29 13:37:06	3	1	173	0	40	114	0	161.60	33	94.94	CHANGED	KR.....llulLhAslslllsuusGhhsWhLsRcsuPppPEISAYSHG+hsRVGPYpYCslls.c-.......Cpsspsp..GELsVst+tPlQLSlPpsIucAPWpLLplY-DPssssssh....aR..PsophAVTIP.oVDP.....pRGRLsGltVQLlTlVhDc..sGE.pslPHAEWSlcss	............hlAhl.sllVlllus..ss..uts.h.Wh.h.s.....ts.p.s.P.ppPcIosh.S..cGchpcVsPa.aCsls.s.p............................C......p.s...s.....p.st......spLs.......Vstc.tslpLSVPctIucsPWpL.Lpl.Y.pDPussspsh.........ap..ss.s.phu.VTls.......olDP.......pRsRLssltVph.l..........sl.s..........h.Dc..sG-.pshs.spWSVph.h.............................................	0	8	28	37
+10802	PF10970	DUF2772		Protein of unknown function (DUF2772)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as spore germination protein GE however this cannot be confirmed.	25.20	25.20	26.00	66.70	24.10	23.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.61	0.71	-4.04	10	140	2009-01-15 18:05:59	2008-07-29 13:38:11	3	1	138	0	20	94	0	122.30	52	94.64	CHANGED	sShVpsh+lsSlGISSVlQlGDopcIsh+o+sLAVQRphslFassEG...ctcpFplFs.cPIPhPtsposVps.shhHEsPsIcVpul+lhGlSuSSllpIGSTstVpu-SRlKHIRQLhs.....Psup	...lSlVQNVsIlSLGIuuVFQVGDuNQhELKSRALAVHRElPsYl+sEG...+hDAFcIFTDEaITIP+.R.T.....TD....V+l.NIlNE.CPFIEVNNVclRTlLNSusFQIGNVDYVFsNSRIhQIRQaIT..P...up......	0	4	12	14
+10803	PF10971	DUF2773		Protein of unknown function (DUF2773)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	40.00	40.00	24.40	17.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.69	0.72	-4.01	3	466	2009-01-15 18:05:59	2008-07-29 13:38:37	3	2	290	0	3	167	0	76.90	66	18.48	CHANGED	AL+NAHTPsuLLTTLTEPcaRSLAMNNPQLAADVKTAWLKEDPSLLLFVEQPDLSLLRDLVKTGATRKIRSEARH+LEEKQ	...........ALpNtHTPsulLss.h-Pp.h.lAhNNPphssDVhpAhLKcDP.LhLhlspP-LsLlRpLshsGtTRtIRppAh++L-Eh..	0	2	2	2
+10804	PF10972	DUF2803		Protein of unknown function (DUF2803)	Pollington J, Finn RD	anon	Pfam-B_1049 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	33.30	25.00	19.10	22.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.32	0.70	-4.83	51	345	2009-01-15 18:05:59	2008-07-29 13:47:24	3	2	277	0	85	277	98	147.80	25	71.11	CHANGED	hhtllsLlhlhhus......sAhA..................pphacVEVllFcpss......tpssEpWs.tps..hpsspshslhs..............................................................................................................................................................................ttt.hhLspsphpLsshtpcLpppssapsLlHhuWpQshh.scssu..........sl+lhuGcphsppa.............................................................................................................................................................hpl-Gslplalp+.....YLal-ssLplpp	...............................................................h....l.llhh..hhu.......suhA..................tt.aplElllFcpss............t.ssEpWs.tt...ht.pt...h...........................................................................................................................................................................................................hhs.pt.tL.......ss.hppLpppssapsLhHhAWpQs.t....ppu..........s.htl.uGpchttpa.......................................................................................................................................................................tl-Gplplhht+.....alhh-s.h.lp..........................................................................................	0	20	38	65
+10805	PF10973	DUF2799		Protein of unknown function (DUF2799)	Pollington J, Finn RD	anon	Pfam-B_1111 (release 23.0)	Family	Some members in this family of proteins are annotated as yfiL which has no known function.	25.00	25.00	31.90	31.10	23.20	19.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.42	0.72	-3.96	46	616	2009-01-15 18:05:59	2008-07-29 13:48:22	3	4	513	0	80	303	17	85.20	45	64.46	CHANGED	ssWtphGhpDGhpGpstps.sphtctssp.sht..sshttYppGYpcGttpYCs.s.uYplGhp........................................GptYhGlCs.s.....pFtppYppGpppa	.........DWYslGhcDAloGss.h..+.sscuau-s......p..ADpuhYhcGYtEG.pcchCpsDhsYthGLSG+sa...usCsssE.pAsph+csWQ+GtcE.p...........	0	14	32	52
+10806	PF10974	DUF2804		Protein of unknown function (DUF2804)	Pollington J, Finn RD	anon	Pfam-B_1045 (release 23.0)	Family	This is a family of proteins with unknown function.	25.00	25.00	25.30	26.60	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.95	0.70	-5.59	56	302	2009-01-15 18:05:59	2008-07-29 13:50:15	3	3	259	0	114	274	21	317.20	26	94.31	CHANGED	GpspaGthpu.spslshtchshhp.hcpshssht+hh+hKpapahslhssc..ahlulAluDlpYlusuFsYlaDhcssp..................hhppshlpPh.............shthphsspshpu..ps...papptphplph..p......................t...psthclp..............hsspslps-lplp..sststslslssPsuhs.G..a.saTpKpsulslpG.pl..plsscs................hs...hs.................puhAshDaotGah++cT..sWpWAohsuhhpt..........G..plGlNL.uuGhs-..TussENslWlsGchahL.sslpFcas+......ps.h.......t.........sW+lpS.....p.cscl...-LpFpPhspRp-+hNLhlltSsF+QhhGpFsGpl.hsss...GpplplcslhGhsEDHaA+	.............................h.s.hpt.spplshpch.hhp.hppslpu.......+hh+hKcapahslhssc..ahlulsluDlsYluhuhsYlhDh.pss.p.........................hh.ppshlpP...h......................ththphsps....shpu..ps.........ph.pp.tphplph...p...................................................p..puthplp.................hpst.slphchplp....ssstpsl...slssPhuhss....apYTpKps.slsspG..pl...phsspp.......................................hs....hs......tpuhAshDaupGhhphcT..tWpWu.uhsuhsp.....................G...tlGlNL.usGhs-....os..tsENsla.lsG...c..hphL.ssVpFchsp........................ts.h...............p................sWplpo.....t.sspl...-LpFpPhhpRp.pc..hNlhl...ltSsh+QhhGpFsGpl.thss...GpplplcshhGhsEcphA+..............	0	52	83	103
+10807	PF10975	DUF2802		Protein of unknown function (DUF2802)	Pollington J, Finn RD	anon	Pfam-B_1126 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.50	25.50	25.50	25.50	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.14	0.72	-4.22	44	303	2009-01-15 18:05:59	2008-07-29 13:52:17	3	1	299	0	84	222	66	70.00	42	48.15	CHANGED	lshGpcltclcpplp.plpp+lpcl.......p.ppDPpsthYscAsKhVphGAsl-ELhppCsLs+AEAELlhpL+pp	.....................................luhGp+lpEhpchlp.pLs-+l.pcL...........E.ppDs.suphYo+AsKhVpLG.AslsELhpcCcLs+AEAELhhpLpp....	0	22	43	66
+10808	PF10976	DUF2790		Protein of unknown function (DUF2790)	Pollington J, Finn RD	anon	Pfam-B_1206 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Pseudomonadaceae.	20.70	20.70	21.20	32.40	19.30	18.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.86	0.72	-4.19	48	247	2009-01-15 18:05:59	2008-07-29 13:56:06	3	1	62	0	76	187	5	82.00	36	89.77	CHANGED	hhlsshussAhApssssps.......................s.lppYcYGMpLDlA+Vluhos.ss..ssC.pVVPupMsYcDSpGch+tlpYpthGs.uCpp	..........................h.hlhshu.hAhAtpstptstt.....................stlcpYpYGMpLDlA+Vluho...sss..ssC.tVVPupMsY-DSpGph+slpYpshGs.uCs......	1	5	19	46
+10809	PF10977	DUF2797		Protein of unknown function (DUF2797)	Pollington J, Finn RD	anon	Pfam-B_1162 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	25.50	25.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.62	0.70	-4.73	54	434	2009-09-11 12:03:15	2008-07-29 13:57:29	3	2	422	0	141	419	288	227.10	37	82.58	CHANGED	G+plslpasGtI..pClsCG+cTKKSasQGaC.........asChpcLA.....pCDtCIM+PE...tCHactGTC.R-PpWucptChpsHhVYLA..NoSulKVGITRpoQ..lPTRWIDQGAspAlsIhcVssRhhuGllEstLpcp..luDKTNW...RpMLKups-.slDLhspcspLhphlspplppl.......................h.thst.......ht...p..thhplsaPV.paPpKlpShNhDKsPplp....GsLhGIKGQYLIhDsG....VlNlR+asGYpls	.............................................................GpplplpahGtI..hCspCG.c+TcKSau.QG.aC..................asCh.p.c.lA......pCDhCI.h+PE.....pCHact..GTC.R-spaucphChp...sHhVYLA....NoSslKVGITR..pop..lPTRWlDQGAsQAlPIhcVsoRhhuGhlEstLtpp..luD+TsW...RphLKGc.sp...slDLhthpppLhtt.h..sp.tl..tpl............................ttphu..........slp..l..pt...t.hplpYPV...pa...PpKl..p.Sh.N.l-..KsPhlp....GhLhGIKGQYLlh.DsG.......VINlRKasuYpl............................................................................	0	34	85	122
+10810	PF10978	DUF2785		Protein of unknown function (DUF2785)	Pollington J, Finn RD	anon	Pfam-B_1219 (release 23.0)	Family	Some members in this family are annotated as hypothetical membrane spanning proteins however this cannot be confirmed. The family has no known function.	25.00	25.00	25.20	25.10	21.60	24.50	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.76	0.71	-4.82	29	640	2009-01-15 18:05:59	2008-07-29 14:24:14	3	3	450	0	63	382	3	163.20	34	63.61	CHANGED	LhhcIspttsD.ulFpRSFos...LllAhllptcpp.....h.hLosp......phpplhpphlpYhthEpDhRGalppcGWAHuhAHsuDhLspLsppsph.spschhhl..lpslh.phlpp.sthahssE--RLupslhshlpps.lspcplhthlpph.....tshsshpt..t...s.hhthhNhppFLpsLhlp	............................Lh.pl...p.tpt.ushpRoFss...LlhuhlLpscpp.....h.hLopcphpslhsQhlpYlshE+Dh+Gas.p.phGWsHuhAHuADhLsEllppsph.sppphcEl..hssLt.phh.+h.hohhaps.sED.RLspslhphl.ps.lpp-plhshl+sl......phs..cp......p.hhh.htNh+shLpplahp............................	0	24	37	46
+10811	PF10979	DUF2786		Protein of unknown function (DUF2786)	Pollington J, Finn RD	anon	Pfam-B_1231 (release 23.0)	Family	This family of proteins has no known function.	22.20	22.20	22.30	22.20	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.99	0.72	-4.24	127	678	2009-01-15 18:05:59	2008-07-29 14:24:43	3	4	601	0	146	563	51	41.60	35	15.60	CHANGED	pKhLp+ItKLLthup.u..ss.pEAtsAhppApcLMtcaslcts	....pKhLp+Ip+LLthAp.u......ssttEAtsAhppApcLMtcaulst..........	0	43	88	127
+10812	PF10980	DUF2787		Protein of unknown function (DUF2787)	Pollington J, Finn RD	anon	Pfam-B_1249 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.70	19.70	20.70	21.70	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.85	0.71	-4.19	38	284	2009-09-11 12:53:47	2008-07-29 14:26:16	3	1	121	3	38	170	13	107.90	36	89.71	CHANGED	sppLtplLsphls......t.pt.ssuptlslNFRD.sYSA-pGGaHPVEIplp+.....psspWplsYITDFuYhG.shasELp+-LDFcFpst.sapthtG.hhslp...psp-LaplWppNFlsY.hshssac.lplos	............s...hpthLtthlp......p.ph.tpuctllhNhRD.sY.tcptGhHPVEltlpp.....pps.W.l.alssFuY.s..s.hspL-hpL.Fchtpt.haps.tGhhs.ltts.-st-LaplWpssFhta.lshpsap-lplT.............	0	12	15	27
+10813	PF10981	DUF2788		Protein of unknown function (DUF2788)	Pollington J, Finn RD	anon	Pfam-B_1255 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	39.30	39.10	22.70	18.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.23	0.72	-4.17	33	319	2009-01-15 18:05:59	2008-07-29 14:26:59	3	1	319	0	80	181	25	51.90	46	72.55	CHANGED	lhlsslhhaMuFIIaDLuK+SpAG+FGphllFhsLulGshGFlhKsllphhh	.....hlsulhhFlGhhIhDlhKpupss+FGphIlaLVLhLGshGFlsKslIphhh...	1	16	42	63
+10814	PF10982	DUF2789		Protein of unknown function (DUF2789)	Pollington J, Finn RD	anon	Pfam-B_1269 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.40	20.40	21.50	69.20	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.49	0.72	-3.96	60	290	2009-01-15 18:05:59	2008-07-29 14:30:47	3	2	263	1	93	240	24	74.30	46	91.22	CHANGED	M-psppshssLFpQLGLsssppuIcpFIspHp..LssslpLt-AsFWosuQtsFL+EplpcDA-WuEllDpLsstL	.....M-psppshspLFpQLGLsusctuIcpFIspHp..LsschpLt-AsFWosuQusFL+EplpcDA.-WutllDpLshtL.	0	19	43	70
+10815	PF10983	DUF2793		Protein of unknown function (DUF2793)	Pollington J, Finn RD	anon	Pfam-B_1370 (release 23.0)	Family	This is a bacterial family of proteins with unknown function.	21.20	21.20	21.30	26.60	21.10	20.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.98	0.72	-4.18	50	230	2009-01-15 18:05:59	2008-07-29 14:32:52	3	6	199	0	76	196	45	87.10	41	24.90	CHANGED	HNEALphL...DuLVQLuVtutshssPPusPupGspalluuu.A.oG..A.WuGps.GplAhapsGu..WtFlsPpsGWtsaltsc....uthhl..ac..GusWt	.......................HNEALphL...DulVpLuVpuhshssPPuoPA-GDRYIVuus.A.oG....A.WuGps.GplAta.s..Gu.....WhFlsPts..GWhuaVssE..............utlhl..ac..GusW.............	0	19	52	62
+10816	PF10984	DUF2794		Protein of unknown function (DUF2794)	Pollington J, Finn RD	anon	Pfam-B_1384 (release 23.0)	Family	This is a bacterial family of proteins with unknown function.	21.70	21.70	23.70	42.40	19.70	16.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.81	0.72	-4.12	33	238	2009-01-15 18:05:59	2008-07-29 14:34:32	3	1	235	0	81	190	1084	84.10	62	68.45	CHANGED	VtFcRpELspILsLYGRMVAuGEWRDYAIDhh+DtAlFSlF....RRuuEhPLYRIEKcPcLup+QGtYuVlutsG.pILKRGp-LtpVL	..sFcRpELstILslYGRMVAsGEWRDYAIDaL+D+AVFSlF....RRuuEhPLYRIEKsPKLtpKQGtYuVlussG.hILKRGH-LppVL.................	1	21	51	61
+10817	PF10985	DUF2805		Protein of unknown function (DUF2805)	Pollington J, Finn RD	anon	Pfam-B_001474 (release 23.0)	Family	This is a bacterial family of proteins with unknown function.	20.80	20.80	20.80	55.90	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.45	0.72	-4.03	58	227	2009-01-15 18:05:59	2008-07-29 14:35:38	3	1	217	0	75	214	1538	70.80	51	81.03	CHANGED	lsRIIEMAWEDRTPFEAIctpFGLsEppVIpLMRppLKsuSF+hWRKRV.oGRpTKHtth+s....ths...RhhsssQ..h	....sRIIEMAWEDRTPFEAIctpaGLsEs..pVIplMRppLKsuSF+hWRKRV.oGRpTKHtphRs......pht.....Rhhs.pQ................	0	28	57	68
+10818	PF10986	DUF2796		Protein of unknown function (DUF2796)	Pollington J, Finn RD	anon	Pfam-B_1354 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.50	25.50	25.80	29.10	24.30	25.40	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.00	0.71	-4.27	46	343	2009-01-15 18:05:59	2008-07-29 14:37:18	3	2	245	0	71	281	191	133.20	31	85.86	CHANGED	tsAH.HGtuclslAh-G.ssL.lplpuPuhslVGFEHAspocp-+ttlspAhspL.ppstpLFslssuAsCplppsplctshhtt.t.t...................+-+csHD....................+pp........................................pHu-hpupYpapCssssp...Lpplshs.hFppFPuscclpVphlsssuQpuscLosssspl	..........................tAH.HG.splsls.-G...ppL.hchpuPuhslVGFEHsspsstpcttlttAht.L.tps.tlFsls.tAtCphtp..lptshhsc.ptpc.t.c.....................+-+.c.tHD.............Hptc...................ccptpccttt.........................................pHu-hpspYphpCtt.t....Lptlpht.hFphFPshpplpsphls.ptQtuhplt.tps..................................	0	19	39	58
+10819	PF10987	DUF2806		Protein of unknown function (DUF2806)	Pollington J, Finn RD	anon	Pfam-B_001505 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.50	24.50	25.10	24.80	24.40	21.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.22	0.70	-4.85	32	239	2009-01-15 18:05:59	2008-07-29 14:37:38	3	1	199	0	53	155	23	210.80	36	73.28	CHANGED	tpRutpRtptpttppQpNlEsIhthAhsh...s.s-ssucs..hDsDWltpFhphAccIpsppMQpLWu+ILus.ElppPGoaSh+oLpsL+phTp+EAphhp+ssuhusphss-tp.cll.uhh.t.s.hphhpc.sspslsluphGlsauslLpL.-lGllptsE.....hEouplshsptlphphpspshpLps+pss.........lhhsYY+hTssGsELsp........Llss.........cssppYhctLts	.......................................h.pRAhpRtpppptp+QpNlEpIhthAtsp......scs-..ssu-s...DpDWlh+FF-hApcIpNspMQcLWAplLtp.ElsNPGshSh+sLchL.psMT.KEApllp+ssuhusphGu.-pph+ll.Ghh.t.....................uhhshsc+hsspsl.slupatLsYuSLLhLh-lGLlpssE......hEoG.cl..phcssl.hls.Y.pGpsh...p.....Lpspscs.........lplhYY+FTssGsE.Lsp........LlGs.........KsstpYa-tl..s...............................................	0	10	23	39
+10820	PF10988	DUF2807		Protein of unknown function (DUF2807)	Pollington J, Finn RD	anon	Pfam-B_001516 (release 23.0)	Family	This bacterial family of proteins shows structural similarity to other pectin lyase families. Although structures from this family align with acetyl-transferases, there is no conservation of catalytic residues found. It is likely that the function is one of cell-adhesion. In PDB:3jx8, it is interesting to note that the sequence of contains several well defined sequence repeats, centred around GSG motifs defining the tight beta turn between the two sheets of the super-helix; there are 8 such repeats in the C-terminal half of the protein, which could be grouped into 4 repeats of two.  It seems likely that this family belongs to the superfamily of trimeric autotransporter adhesins (TAAs), which are important virulence factors in Gram-negative pathogens [1] [2].  In the case of Parabacteroides distasonis, which is a cmoponent of the normal distal human gut microbiota, TAA-like complexes probably modulate adherence to the host (information derived from TOPSAN).	21.90	21.40	21.90	21.50	21.80	21.30	hmmbuild  --amino -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.03	0.71	-4.75	118	860	2012-10-03 02:33:51	2008-07-29 14:38:36	3	13	349	33	304	1003	203	162.60	17	72.10	CHANGED	sFsplp.lssshslhlp.p...u.spp.plplpuscsl.hsplpspl..c...sspLpIphc......cshsssp..............h.......hlplshss.Lptlshsuu.uplpsps......................lpspphplph............sGuGslplp.lpspplpsphsGuuslp.ls....................Gpspphpl.pls......GuGplcupsLp.sppsplplsGuGshplt.sspplcupls..GuGsltht..GsP	......................................................................................................................................................aptlt.ht.s.sh.pl.hh..p....u....st...pl...l....p..s...t.p..p.h..hp.l....p.hth...p......sstLh.lthp.........................pthp..t..................h........lhl......t...h...p...l.ptlp.h....s.u...s..uslp..hps...............................................................l.p.s..s.p..h.p.lph................................sGu......usl...p.h...p...l..p.s.s...p.l.php.h..s.G..u.uslp..lp.......................................G.p..s.p.phph..phs..........Gsu...pl..ps...t.p..lt....sppsp.h.ph.pusuphph.....s...p...t..p..l...p..hp...ht....usupl.h.s...........................................................................	0	98	229	290
+10821	PF10989	DUF2808		Protein of unknown function (DUF2808)	Pollington J, Finn RD	anon	Pfam-B_001529 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	22.20	22.20	22.30	23.00	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.66	0.71	-4.58	57	175	2009-01-15 18:05:59	2008-07-29 14:42:16	3	6	79	0	83	185	160	141.50	22	69.84	CHANGED	uhh.F.......s.ps.pplphhpspsttp..ptspahhhlhspcttpultplslsh...Pctacs..thpspplplpthp.s.........tpplP...stsphsp...s....spslplh.spPlssG.sslslshpslh.N..PptsGhYpFsspuhssGss..PhstalGohplsl	.................................................F....sps.phlphhts.stht..tsphYhhhhhspstspsltplslsh...spthcs....hphptlpspsh..t....................spsls...tpsphsp...c....spslslhhspPlssG.sslslslpslp.N...PphsGhYhFsspshssGps..shshalGshhlph............	0	16	57	79
+10822	PF10990	DUF2809		Protein of unknown function (DUF2809)	Pollington J, Finn RD	anon	Pfam-B_001533 (release 23.0)	Family	Some members in this family of proteins are annotated as yjgA however currently no function for the protein is known.	23.50	23.50	24.70	24.30	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.96	0.72	-3.58	49	416	2009-01-15 18:05:59	2008-07-29 14:43:19	3	4	395	0	103	363	9	94.20	33	68.37	CHANGED	GLhs+p........salpsahGDlLhshhlahhlthlhst............shhhluhhsllhuhhlEhhQlapsshl.sl+ssplutllLGssFsWhDlluYslGhh	..................................h.s+c........shlpsYlGDsLaslhl.ahhhthlhsph...................pstpluhhuLhFshhlEhuQLapsshl.slRss...slutllLGp..sFsWtDlluYslGs........	0	38	73	87
+10823	PF10991	DUF2815		Protein of unknown function (DUF2815)	Pollington J, Finn RD	anon	Pfam-B_002212 (release 23.0)	Family	This is a phage related family of proteins with unknown function.	21.70	21.70	22.70	22.30	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.13	0.71	-4.74	20	443	2009-01-15 18:05:59	2008-07-29 14:50:00	3	2	386	0	55	299	47	172.00	42	92.86	CHANGED	TKVlTsp.VRLSYs.plaEPcuh.sGp.....csKYSloll.......IPKuDspTlpuIcpAIcsAhcEGh.uKh...GsKhs..sslKhPLRD.GDh-ps.D-..tYss......saFlNAsS+p...+Ptll.....D+sspP...............l...h-psEVYSGCYuRsSIsFYAasssGNKGIusGLsNlQhl+DGEsLG.G+s.sAEDDF-slp..s-DD	.................................................................................................hKVlTGp..VRhSYs.plaEP+oh....pGp.....csKYSloll.......IP...Ko.D...sp...Tl.....p.......tIcp.AI-sAhc-..Gh..uKh......Gtpls.........usLK.h.PLRD.GDh......E...Rt.....-..........D....sY....ts......saFl..NAsSpp.....tP.tll.........Dpstp....................l....h-puclYSGsYsRsSI..s..h..au...a.N..o..NGN....KGIAsGLsNlQhlc..DGEsLG.Gts...uA-DDFsshsps.............................................	1	28	46	52
+10824	PF10992	DUF2816		Protein of unknown function (DUF2816)	Pollington J, Finn RD	anon	Pfam-B_002257 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	37.80	36.10	20.40	17.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.24	0.72	-4.38	12	70	2009-01-15 18:05:59	2008-07-29 14:53:14	3	1	3	0	60	73	1	63.00	55	23.64	CHANGED	EYEppppp..VPhp+hlTDYYsVEYpTEYIPQshhEK.lEYVPV-+ht-RV-YhsVERpsshp	.EYEEpppp..VP+E+hVTDYYAVEYQTEYlPQVh.EKhsEYVPV-RhpERVEYhsVERQVV+p......	0	60	60	60
+10825	PF10993	DUF2818		Protein of unknown function (DUF2818)	Pollington J, Finn RD	anon	Pfam-B_002280 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.20	25.20	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.20	0.72	-3.49	21	217	2009-01-15 18:05:59	2008-07-29 14:54:45	3	2	214	0	65	167	17	94.20	50	91.41	CHANGED	uulWlllLLALluANLPF.lspRlhslh.Phts......KshhhRLlELllhYhlVGhluhhLE.pphGpltsQGWEFYAIThsLFllhAFPGFVYRYLh++	.....................uhahlllLALlsANLPF.LspRLFull.Pl+p............Ksh...hh+lhELlshYhlVGsLuahLE.uRuGshasQGWpFYAlThsLalVFAFPGFlaRYhh+...................................	0	12	36	51
+10826	PF10994	DUF2817		Protein of unknown function (DUF2817)	Pollington J, Finn RD	anon	Pfam-B_002258 (release 23.0)	Family	This family of proteins has no known function.	19.60	19.60	19.60	19.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.95	0.70	-5.36	32	141	2012-10-02 19:46:12	2008-07-29 14:55:34	3	3	121	0	72	727	173	323.40	32	89.81	CHANGED	F.up.oYspARp+FLsAAcssGs.....plpsashsh..GssGEsLuhDlAhhGsscApp.lLlloSGsHGlEGasGSusQlshLp-t..hspshssssul.LhlHAlNPaGFuahRRssEcNVDLNRNFl.......DaspshssNssYsclpshLlPsphsss...tt..tptslhphhtp+GhtshppAlssGQYpaPcGlaaGGptssWSstsL+pllpcah.sss..c+lsaIDlHTGLGshGtsphltts..pcssshp+spphaGst....ltshhss......sususshpGhhhpu...h..hphhsshp.hsulslEF.....GThsshpVhpALps-pWLah.................asc.sss.sptttl.+pplt-AFYPssspW+ptVltp	..................................................................................................................FupsYtpARp+FlsAA...pstut.....tlppa.pst.....G.....ssGEsLsh...Dl.Ah.......hGs.t.c..A..p+..lLllsS.GsHG...V...E..G......asGS.us..Q.....l.....s..h....Lpct..........hs...p...th....s........s...ss...ul....L.....hl.HAl..NPaGa..A..a..h..R..Rs.sEcNVDLNRNal........Da.s.p..shss....N...ssYtpl.p....shLhPsphsss...tt...stttl.tphhtpcG.suhppAlstGQYphPcGlFYGGptssWSptslcpllpcah..uss.......pclshIDlHTGLGshGtsph...lhts...psssthpcAt..p..h.aGss.............ltshhsu.......sususshpGhh...hps...h....hphh.s...ptp...hsslslEF.....GThss.......p...h..hpALp......s-pWLah.................a.sc.sts..sttttl.+ptlt-uFYs.ssssW+thll.........................................................................................	1	19	37	62
+10827	PF10995	DUF2819		Protein of unknown function (DUF2819)	Pollington J, Finn RD	anon	Pfam-B_002304 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.10	19.10	19.80	20.60	17.80	17.50	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.60	0.70	-5.67	20	554	2009-01-15 18:05:59	2008-07-29 14:56:58	3	1	539	0	47	328	5	305.80	70	59.78	CHANGED	hstp+tlu.GLAsLpp.spsphtapVsaWpscpGVsuspphhLptsssshhhsssppsstpst.......tsDEcRlhsspssl-tus.lPppWplh-sNssLhstups..spAATllFuhsppspl-tLApplapLRRppGstLKIlVREs.pssLRtsDEpLLLssGANLllstssPhSRhLThIEulQGQhFoR.lPpDlcsLLsh.spshth+GYlssssFsptVpshhssohhsp.lptsLVpLphlPGlpstpsLpLC+hRRsGDlsTsssspLYLFLpACRhNDl-sALspIFclPlsDlFsschlatsptpIpuElppl	.....................hpEYRSLF.GLASLRF.QGDQHLhDIAFWCNEKGVSARQQLslpQQsshWTLsppEEstIQP.........RSDEKRILSsVAVLEG.APPLSE.HWpLFsNNEsLFN-ART..AQAATlVFSLpQNsQIEPLARsIHTLR..RQRGS..AhKIlVREN.sASLRATDERLLLuCGANMVIPWNAPLSRCLThIES.VQGQpFSRYVPEDITTLLSM.TQPLKLRGFQp...WDsFCsAVpsMMsNsLLPAcGKGVLVALRPVPGIRVEQALTLCRPNRTGDIMTIGGNRLVLFLSFCRlNDLDTALNHIFPLPTGDIFS....NRMVWFEDcQISAELVQM......................................	1	5	11	29
+10828	PF10996	Beta-Casp		Beta-Casp domain	Mistry J, Wood V	anon	Manual	Domain	The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease.  The active site of this enzyme is located at the interface of these two domains [1].	20.30	20.30	20.50	20.80	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.83	0.71	-4.19	183	2338	2009-09-11 08:10:03	2008-07-30 13:33:19	3	44	1375	45	1245	2305	359	124.90	25	21.06	CHANGED	sQEllhh.......Lpchhp...ptt...........................hslalDSshuhcssplap..pa..chhs...p.h....pphht.tt...................................h.ph.phh..............cshcpscp.........l..p..t.t.P........s...lIluuoGM.hsuG....hlhcalcphhscs+Ns.llhsG...aQupGThG......+pl	.......................................................................................sQELlhh.......Lcphhpptt..............................................tphPlals..SshAtcssplap..pa..hp..hhs.ppht............cphhttpt........................................F...p..h..phl.........................................pshccppp...........l...tt.t...t..P............slllAusGM.h.puG...hshcah.c.ph....t....s....c.t+....Ns.llhsGYpspGThG+pl...................................	0	446	759	1049
+10829	PF10997	DUF2837		Protein of unknown function (DUF2837)	Pollington J, Finn RD	anon	Pfam-B_002349 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.40	20.40	21.80	21.10	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.45	0.70	-5.22	23	271	2009-01-15 18:05:59	2008-07-30 15:56:18	3	3	243	0	64	198	15	241.70	42	92.79	CHANGED	LThlIHlIsTLAYusRluGVRTt+lAsAhSLFNlhsLlSRsuNhhQuPLlupll-pulp.....................tpthusLtsphRh.llhuATlGTllGhlLlPTFlplFs+AIhth.cpsGSVP+Lhh+sh..ohpslcphcpplplPphp.lcpht...hppIP+cllllNhllouIYTlGVLuALYAGhLsPE.aRsTAutLSullNGhATILhslhlDPphSllTDcslcGcpspt-l+phshhlsho+llGTLLAQhlFlPuAhhIsalsc	.........................hThlIHsl-TluYulRLuGVRsp+IAlAlSlhsllhLlSRTuNhlQuPLlGtlVDpuhh......................sss....hsL.t.hRl.lLluAolGTlluhlLhPThh+lFuhsIpph.-ssGS.h.+hhhpsh..sh.p.tl.+hh+c..hl+hPphphlcplp...htsIPK+lhllNhhsTuIYTsG.VLSuLYAuhLh.P-.atosAsshSGlINGhATILLslhlDPplullTDcslpucpstpshpphhshLhhoRlhGT.LLAQllhlPuAhhIhalh.p.......................	0	24	47	53
+10830	PF10998	DUF2838		Protein of unknown function (DUF2838)	Pollington J, Finn RD	anon	Pfam-B_002381 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.20	25.20	28.20	28.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.86	0.72	-10.55	0.72	-4.18	23	224	2009-01-15 18:05:59	2008-07-30 16:17:06	3	5	177	0	166	216	8	108.90	41	24.04	CHANGED	-Klsashulhslh....hsualhGthPphFhhaYTshhhhhMPlRaYoYpKpsaHYFLsD....hCYFlNhLsLlaI.....W.........laPpStpLFlssasluhGsLuhAlIsWRN.SLVhHSlDKlTS	.........-KlsahhGVh..slh......hsualhGthPphhhhaYol.hhhhhPlRa.as.Y++..p...saHYFLhD....................hCYalNh...Lhllhl......W...................haPp..SppLFhs.sasluhGsluhAl.lhWRN.SLVFHShDKlTS..................................	0	67	116	150
+10831	PF10999	DUF2839		Protein of unknown function (DUF2839)	Pollington J, Finn RD	anon	Pfam-B_002396 (release 23.0)	Family	This bacterial family of unknown function appear to be restricted to Cyanobacteria.	21.90	21.90	22.90	23.50	21.40	21.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.45	0.72	-3.94	37	107	2009-01-15 18:05:59	2008-07-30 16:21:36	3	2	77	0	38	103	267	65.90	40	86.86	CHANGED	MGEAKRRppp.GLsP+ptcppp.........hlshlPlocpQsp.hhtloh+usWlGIuhLslhWlslphl....GPssuWW	........MGEAKRRcph.sLss+ttpppp...........llsWlPlT+sQsc.hhphos+uuWlGIuhhshhWlslRhlGPshGWW...........	0	6	25	36
+10832	PF11000	DUF2840		Protein of unknown function (DUF2840)	Pollington J, Finn RD	anon	Pfam-B_002399 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	25.50	55.60	21.70	19.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.87	0.71	-4.66	34	168	2009-01-15 18:05:59	2008-07-30 16:25:56	3	1	109	0	89	180	13	146.90	51	87.02	CHANGED	LTcVELsWlEKRlEpWIRFG+sspEpllDRpRRlsuFtPuulFAFVRWAuNDaGTllSRlDIlRAlsPG-uaQTlPaV+PGG-lLL+lpGWPKVEcVLptIDAlEAlGIDPs-suPDaWRHVHNRLuAut.PRsYTt-RHtAWLtRRpl	................................LT+VpLsalEcRlEhalRFGcsucpphL.....DRpRRlssFtPGulFuhVRWtANDaGTlhSplDIlpAssPs-shQTlPhVcPGu-lLL+hcGWs+VcpVLptIDAIEAlGIsPs-VuPcaWRcltNRLuAs.s.psYTtERHtAWLtRRt.h......................	0	9	54	74
+10833	PF11001	DUF2841		Protein of unknown function (DUF2841)	Pollington J, Finn RD	anon	Pfam-B_002409 (release 23.0)	Family	This family of proteins with unknown function are all present in yeast.	23.50	23.50	24.30	30.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.87	0.71	-4.27	34	181	2009-09-11 16:39:17	2008-07-30 16:29:38	3	2	115	0	128	184	0	134.50	39	28.24	CHANGED	L.l.uss.ptlhpaYppsFcplQQhsC+tIAKAaIKllEP+KQspa.PYsttc..............poKPsWWP........ssVpH+EPDHLpK....................-RlpLLlaIlpphh.............hhsst+Lcpsstcstpt.hps.......t+hplLcEIacVtchE	.........pluspptlpsYYcpuFcshQQhsC+tIAKAaIKllEP+KQspa.PYsGuc..............poKPsWWP........psVhH+EPDHLpK...................s-RlcLLlHIlpplht............htl.ssc+Lc-sstsspp..p...hps.......c+h.lLcEIacVtc.....................................	1	19	56	103
+10834	PF11002	RDM		RFPL defining motif (RDM)	Mistry J, Bonnefont J	anon	Manual	Domain	The RDM domain is found on RFPL (Ret finger protein like) proteins.  In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex [1].  The RDM domain is thought to have emerged from a neofunctionalisation event.  It is found N terminal to the SPRY domain (Pfam:PF00622).	27.00	27.00	45.00	58.70	22.70	20.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.76	0.72	-4.29	23	72	2009-01-15 18:05:59	2008-07-30 16:34:42	3	3	20	4	24	79	0	42.00	65	13.91	CHANGED	VVSQKsDI+PshQLGpLVS+IKELEPpL+slLpMNPRM+KFQ	.VVSQKNDI+PshpLttLVS+IKELEPKL+plLpMNPRMRKFQ	0	6	6	7
+10835	PF11003	DUF2842		Protein of unknown function (DUF2842)	Pollington J, Finn RD	anon	Pfam-B_002411 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	30.20	30.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.13	0.72	-4.11	51	214	2009-01-15 18:05:59	2008-07-30 16:46:55	3	1	213	0	71	172	148	61.50	37	83.93	CHANGED	RKhluhllLllhlslYhllusslsshhh....p.shhlphlhYlllGllWl..LPhthlhphhsps-	...RKhlGsllLlshlhlYullAsslAsthlh....ssshWscLlaahlsGllWl..LPAhslltWMupP.....	0	17	44	53
+10836	PF11004	Kdo_hydroxy	DUF2843;	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_002426 (release 23.0)	Family	This is a family of 3-deoxy-D-manno-oct-2-ulosonic acid 3-hydroxylases, which catalyse the conversion of 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) to D-glycero-D-talo-oct-2-ulosonic acid (Ko). It contains a potential iron-binding motif, HXDX(n)H (n>40). Hydroxylation activity is iron-dependent [1].	25.00	25.00	38.70	74.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.69	0.70	-5.41	13	168	2009-09-10 20:14:51	2008-07-30 16:52:13	3	2	164	0	50	124	11	277.40	55	93.40	CHANGED	cWsspss.sc.ttshhstLEpGKVLaFPcLsFsLsscEc.shLcPsh........sDsKpKNIShcPppGsl+G............ssscssstttlpullsRapppstsLlppLLPpYsssL+husTShR..PsphtsRssSWRKDDoRLHVDAFPSpPshGcRILRVFoNINPcstPRlWRlGEPFcshA+RFl.Ppsps.hP.hpuhL...........LptLtlTKph..........RSpYDHhMLpLHDtMKuDh-YQ+suPQ.pphsFPPGooWlsFSDQssHAsMSGQaMLEQTaaLPscAhtcsppSPLplLE+LsG+sL	..........t.Wstp...ss.tpphltuLEpGKVLaFP+LpFslpstEc.tLLDPsl........sDsKRKNIShcPptGsLpG............VsG.D...uss..utlRsLlsRatppAtsLVssLhPpYp...stL+sAsTSLR..PhpltsRpTSWRKDDSRLHVDAFPSRPNYGERILRVFTNlNPpGtPRlWRVGEPFpslA+RFL.Pplcs.sP.hsAWL...........hchL+lTKp...........RStYDHLMLpLHDtMKADL-YQKsuPQ.QshsFPPGSsWlCFSDQssHAsMuGQFMLEQTFaLPVpuMtpsppSPLtILE+LpG+sL...	0	9	26	37
+10837	PF11005	DUF2844		Protein of unknown function (DUF2844)	Pollington J, Finn RD	anon	Pfam-B_002433 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.20	21.20	21.90	40.70	20.30	16.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.63	0.71	-4.36	22	138	2009-01-15 18:05:59	2008-07-30 16:55:01	3	1	72	0	46	122	8	136.00	42	85.09	CHANGED	ApAsLGusssossusstshst.........................sttssssssuYol+phs.usGT..........slREYsssuGhVFAluWpGPshPDLssLLGoYhspahsuspt....tttsttshtVpssDlVlcouG+htsasG+AalPshlPuGVsss-l	........................ApAtLGGsshossAsststss.........................ssuussss..suYTl..RphshuuGT..........sl+EYsosuGsVFAluWpGPshPsLssLLGuYFPpYpuuspssc....tA+uspssstVssuslVlcoGG+MtuasGpAWLPsALPuGlossDI...	0	5	18	29
+10838	PF11006	DUF2845		Protein of unknown function (DUF2845)	Pollington J, Finn RD	anon	Pfam-B_002437 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.00	21.00	21.30	21.10	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-9.88	0.72	-4.15	40	206	2009-01-15 18:05:59	2008-07-30 17:05:35	3	2	125	0	59	181	22	83.40	32	79.66	CHANGED	sssuohRC.s.sslVohGDsth-VLtKCG-Ps...............p+s.hststst...............tthsttspsplE......cWsYshGP.sphhphlpFcsG+LscIcstt	............tssohRC.G.spLVstGDsth-Vl....t+CG...pPh...............s+cshshshsh...........................sthh...ptptsplE...........cWlY..GP....sshhhhLpFcsu+LhcIcst.t...........................	0	21	34	50
+10839	PF11007	CotJA		Spore coat associated protein JA (CotJA)	Pollington J, Finn RD	anon	PRODOM	Family	CotJA is part of the CotJ operon which contains CotJA and CotJC. The operon encodes spore coat proteins. Interaction of CotJA with CotJC is required for the assembly of both CotJA and CotJC into the spore coat [1].	25.00	25.00	26.10	25.90	22.80	20.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.52	0.72	-4.30	50	348	2009-11-09 12:01:11	2008-07-30 17:14:02	3	2	319	0	62	234	1	37.80	39	49.19	CHANGED	htlAhAYVPhQpap.s..hY.ssccALppGTlFP-Lst.........Pa	......p.sphYlsaQ..hs.s...a.sPc-ALp+.GTlaPsLhcPY...........	0	31	48	53
+10840	PF11008	DUF2846		Protein of unknown function (DUF2846)	Pollington J, Finn RD	anon	Pfam-B_002451 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as lipoproteins however this cannot be confirmed.	34.30	34.30	34.30	34.30	33.90	34.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.35	0.71	-10.54	0.71	-4.26	42	198	2009-01-15 18:05:59	2008-07-31 09:09:09	3	2	175	0	66	183	26	121.40	24	62.95	CHANGED	hloGC...............tstsssphpphtssp.....sp.utlYlY..R.suhhu......s..uhphsl.alsuphlGp.htsssahah-lssGp.aplus...cpthts................splslss-uGcsYalc.p.phss...............hsGsssl	.............................................hsGC.............hhstt.utp.htthpssst..........sp.AslYlY....Rssohhu......t....shthsl.a......lsu..ch....lGp.htsssahah-lssGp.aplus......ppthts................pplslsscuGpsYal+.p.p.sh...............hsG................................................	0	17	33	52
+10841	PF11009	DUF2847		Protein of unknown function (DUF2847)	Pollington J, Finn RD	anon	Pfam-B_002453 (release 23.0)	Family	Some members in this bacterial family of proteins with unknown function are annotated as YtxJ, a putative general stress protein. This cannot be confirmed.	23.10	23.10	23.10	55.60	22.50	23.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.18	0.72	-4.44	34	477	2009-09-11 05:12:55	2008-07-31 09:20:33	3	2	462	1	92	238	54	101.40	49	90.37	CHANGED	hp.LpohpphcplhcpotppssllFKHSTsCsISphuhppacphhstppp..lssYaLclhptRslSNpIAccasVpHcSPQllllcNGpslacsSHhsIstssLp	............KLooI-paEpllEc...Nch..hhlhKHSpTCPIStsAY...cpFppah.Ecc...hcuYYLhVQppR-lSshIAcchsVKHESPQshYhhsGchVWNssHtsIshsuL.s.....	0	34	68	84
+10842	PF11010	DUF2848		Protein of unknown function (DUF2848)	Pollington J, Finn RD	anon	Pfam-B_002463 (release 23.0)	Family	This bacterial family of proteins has no known function.	23.40	23.40	23.40	48.00	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.13	0.71	-4.83	37	154	2012-10-02 17:33:27	2008-07-31 09:27:34	3	2	143	0	64	156	32	191.50	44	83.57	CHANGED	AGWTGRDpsAlp+HIsELstLGVs.PussPlaYRVusshLopuspl.pV.GscoSGEsEhlllps...puplaluluSDHTDRclEsauVuhSKQhCsKPlupphWchs-Vts.HWDpLhLRua.ht.s..G.ppsLYQ-GoLuulhsPs-Llsths...sps.......hss...GsuMhsGTlssh.Gsl...psAspachELpDPstsRolcHuY	.............AGWsGRDtsAlpcHIcELt.t.LGVstPussPhaYRVusshLTQuspl.pVh.Gs.coSGEsEhl.Llps...sGchhVuluSDHTDRclEsauVshSKQhCsKPluppsWch.s-Vts.HWDplhLRoa.hs.s..G.-.csLYQ-GsLuulhsPp-Llpphs...tts.........thss.GsuMhsGTlus....h.Gul...csuspFchELpDPlhsRolcHsY.............................	0	14	28	48
+10843	PF11011	DUF2849		Protein of unknown function (DUF2849)	Pollington J, Finn RD	anon	Pfam-B_002560 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.50	22.50	24.30	33.10	22.20	17.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.99	0.72	-3.74	52	228	2009-01-15 18:05:59	2008-07-31 09:33:50	3	2	227	0	69	182	40	89.40	38	80.45	CHANGED	sKVlTANcLh-GsVVahsusspWoccls-AtlhscctpuphhLttu..ttpsspVVGsYls-sp.sssG.scPs+..hREphRspGPoshhctp	...KVlTANRLhDGpsVWLsAs...GpWscslspAhlhccs-ssssL.ttu...sspsstVVsshllDVc.pp.sG.....lhP..h+...lRE+IRt.pGPTlhs...s....	0	19	44	52
+10844	PF11012	DUF2850		Protein of unknown function (DUF2850)	Pollington J, Finn RD	anon	Pfam-B_002587 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Vibrionaceae.	21.00	21.00	21.30	21.20	20.70	18.30	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.48	0.72	-3.80	16	208	2009-01-15 18:05:59	2008-07-31 09:42:15	3	1	111	0	20	110	1	78.70	42	55.31	CHANGED	plYGpWlE.ssssYAs-phsLospGVhhNsRlluTsF-FDGphlpapsGsshhhYphssstps.pl+phpPuaY.shFhh	...clYGpWlE.ssssYts-plplsppGVhhNsRLloTpF-FDGstlphpsGsthaha-l.sptps..QhKpppss.s...hFh.........................	0	2	5	15
+10845	PF11013	DUF2851		Protein of unknown function (DUF2851)	Pollington J, Finn RD	anon	Pfam-B_002589 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	40.10	35.00	18.50	18.30	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.19	0.70	-5.73	27	226	2009-01-15 18:05:59	2008-07-31 09:46:59	3	2	217	0	67	232	79	357.70	37	86.43	CHANGED	MpEchLHalWpa+hFstps....LpTTpGc.lpllssGhhNpp.uGPDFFNA+lcIsup.hWsGNVEIHh+SSDWahHpH-pDsAYDsVILHVVaEpDs...pI.hRpsss.lPsLhLpthlspplhcpYppL.....htpcp..hlsCtspltslsshhhpsW....l-+LhhERLEpKsphlppLLppspscWEslhaphLs+sFGhplNucuF.plApslsFpslcK.......ppps.hplEALhaGpAGLLp.....tc...pD....pYhtpLpcEapaLp+KapL..pshssp.hpFhRlRPsNFPolRLAQLAsLap+p........psLFSplh.pspohp-ltplhp.lps.............SsYWcsHYsFs+topp+sKp...lucshl-lllINTllPlhasYupptupcphp.phhphlpplpsEpNs	.....................EphLHYlW+a+hFshps....LpTT....sGpslcllcsGhhNps.AGPDFFNA+l+I.ssp.lWsGNVEIHh+uSDWatHtHcpD.sYcsVILHVVh....pt..Ds.....pl.h.c......p.sGp.lPpl.Lp..l.....s.pplhppY..c..pL......htspp.......a.sC..hph..lss.lsphhhpsW....hstL.hERLEpKsptIpphLppspssWEpshFhhLA+sFGaslNu-AFcphAppl.Ph.pslpK.......p+s...sh..hQlEAlhhGpAGLLp..........pp.....pD.......sYhtpLp.cEapaLp+KapL...pshssphW+FhRLRPtNFPplRlAQLAtLatpp..........psLhSplh.pspslpplpplhp.sps................SsYWpsHYpFsp.St.ppp.Kp...lupstlslllINTllPhhasYupppspcth.p...pcshphLcplpsEpNp............................................	0	32	62	67
+10846	PF11014	DUF2852		Protein of unknown function (DUF2852)	Pollington J, Finn RD	anon	Pfam-B_002611 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.50	22.50	23.20	41.40	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.60	0.71	-4.13	35	197	2009-01-15 18:05:59	2008-07-31 09:51:09	3	1	178	0	58	151	19	110.90	47	81.94	CHANGED	shLDscG+sAWIAuMVLGFIhFWPlGLALLuYhIWS....+RMh..sp................uspscptp.t.t+hth.ht...............hpoSGNsAFDsY+t-TL+RLEEEQc.......pF-sFLcRLRcAKDKpEFDpFMs-Rpp	...................s.hlcsthpsAhIAhMVLGFhl.FWPl....GLAhLAYhlau......p+ht.thpc................spttcph.h.th...cptptp.s..................hsooGNsAFD-aRp-pLcRL-EEp+.......-F-sahpcLR+A+DK-EFDpFMs-Rc.s..............	1	11	31	41
+10847	PF11015	DUF2853		Protein of unknown function (DUF2853)	Pollington J, Finn RD	anon	Pfam-B_002619 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	31.80	31.70	21.30	19.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.36	0.72	-3.56	29	185	2009-01-15 18:05:59	2008-07-31 10:25:34	3	1	180	4	55	137	20	101.30	48	93.30	CHANGED	scYhsDlKccsut..sDh-llpKlstuhGPuIYNpDuuhVuuSDtpEL-pV+pNalhKKLGL.sD..sscLcsuIppVhEphGtopRsKaRsshYYhLsK+hsKpSs	...........s.cYhsDl+chsus..sD.sllpKlsptLG.AlhNpDuShVSuSDscELcpV+sNalhKKLGl.pD..sschDcuIscVsEshtss.RNKaRsshYYLlAKphGK.t.h..........	0	12	40	48
+10848	PF11016	DUF2854		Protein of unknown function (DUF2854)	Pollington J, Finn RD	anon	Pfam-B_002643 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	26.30	35.40	20.00	24.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.95	0.71	-4.67	23	116	2009-01-15 18:05:59	2008-07-31 10:33:03	3	2	100	0	54	115	127	144.00	44	69.27	CHANGED	lGhlAYhs........ssssLSLsshFYGlPlLLGGLALK......uuELpP.shptssssplhtlR-p.ATsp.splhpDVTRaRYGQcAHLEsSLctLtL..h....s--p.PpLhtlcEhptpusYuLhLcF-ssuVsl-cWp-K.p-+lu+FFu.GLc............Ac.lsp	..............................hGFsAYhs........ssusLslsshFYGlPlhLhGlALK......suEL+PlP..psots-hhsLR-ppATsp.splRpDVTRaRYGpcsHL-cuLcpLtL.s.....sccphPhLptlcEp.s.h................-.G.pYsLlLcF-us.tlsLppWpc..+..QpKhspFFGPGlpAclt........	0	12	38	50
+10849	PF11017	DUF2855		Protein of unknown function (DUF2855)	Pollington J, Finn RD	anon	Pfam-B_002665 (release 23.0)	Family	This family of proteins has no known function.	27.00	27.00	27.70	27.10	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.78	0.70	-5.28	35	108	2009-01-15 18:05:59	2008-07-31 10:38:43	3	2	98	0	56	115	238	310.10	33	86.50	CHANGED	FAlTANNlTYAshG-th.......sYWpFFPs..........ss...................uaGhlPVWGFAcVlpSpssslssGERlYGYaPhAoc...LslpPscVsssuFhDsusHRpsLsPlYNpYtRssuDstaps..sp-shphLlpPLFhTSaLlsDaLt-ps.......................a.aGA.......ppllloSASSKTAhGLAasLpt....pssuhcllGLTSssNhs.........FVculGsYDpVloYDclssLss........sssslhVDhAGsspllssLHp+hu-pLt....hsshVGsTHhcp.....ts.ssslPusp...sphFFAPsphp+Rhc-WGsssapp+hspuWpsFh..ppu......psalplpchpG.cAhppsYpchlsGclsP	.................FulTANNlTYAhhG-..t..h.......tYWpFFPs..........pp...................saGhlPlWGaApVltSppssltsGpRlaGYaPhuoa...Lhl....ps.sclsttuFhDs...usHRtsLsslYNpYtp..sss....-s..ha..ps..pp-shphLhRPLFhTSahlsDalt-ps............................h.auA.......pplllsSASSKTAhuhAahLp....................tptshcllGLTSssNhs.........FscuLGhYDpVlsY..-plsslss...........ss.slhVDhuGsssl....hspL+p+huc..plt........hss.hlG...hoc.pph...........................ts.stshsusp.......sphFFAPsphpcRhp-hGsst.htp+hstuWppFh.tts......tsalplpphpG.puhppsatplhsGpssP............................	0	16	35	47
+10850	PF11018	Cuticle_3		Pupal cuticle protein C1	Mistry J, Coggill P	anon	PRODOM_PD021041	Family	Insect cuticles are composite structures whose mechanical properties are optimised for biological function.  The major components are the chitin filament system and the cuticular proteins, and the cuticle's properties are determined largely by the interactions between these two sets of molecules. The proteins can be ordered by species.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.70	0.71	-4.12	14	170	2009-01-15 18:05:59	2008-07-31 10:41:37	3	7	37	0	121	192	0	118.90	26	69.21	CHANGED	sssAVuuoppsllRSas..usVSpYSKuVDTPaSSV+KsDoRloNsshp.uhutshh........................................aAAPshs...........huAPshsphAaAAPs.hhttts.......................tPsht..ths.huAPs.........spssYAAsAshhtt.h..................................stslsY.....SPAssV...SHhoas.GhGspYua	............................................................................t.t.t..sshS..ph..p..h...h..........................................................................................................hhh.sAPsht...............hsAPs..ht...t...s.a.u.sPs.hh...tt..........s....................uPsht....p.h..httPs..............h.st.s.....................................u..............................................................................................	0	31	42	102
+10851	PF11019	DUF2608		Protein of unknown function (DUF2608)	Mistry J, Coggill P	anon	PRODOM_PD862984	Family	This family is conserved in Bacteria. The function is not known.	22.10	22.10	22.10	27.30	21.60	22.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.52	0.70	-5.39	27	271	2009-09-11 09:18:18	2008-07-31 10:42:32	3	3	120	0	52	180	6	238.10	23	89.29	CHANGED	hhpspohpcV.tchlppt......pssLllhDlDcoLl.psp.pslups.ahphphpcl......thhts.pcshcplh.chl....hl.phhphchl-sshsphlsp.lpppphslhulophs........shpthphcpLpp.hslsFssss.........h.pps.h...hh.sthspsshahcGIlhosshs+u....tsLphhLsphsthPcpIIalDsspcsltshtpthpp..tsItahGhpYsstpt......s.hsphsps.h.pptphlpschsthhhpth.............sp	...............h.pspshpcl..chltpt......pshLllhslDpsll.ps.........t.p.htppshhph.hppl..........h.s..ppshp.phh.tchl....hh.pptphchlEs..phsshlsp.hpppthslhulophs................shpthhhctLpp.hslsFspps...................pp..........stttptshahpGIlaous..hs+u....tsL.hhLpphshhPc.....pllalssppcsl.shpphhpp...hsIsahGhcYsshph.........h.hspltp.hhh.p..tchlps-hthh..p......t...........................................................	0	12	17	27
+10852	PF11020	DUF2610		Domain of unknown function (DUF2610)	Mistry J, Coggill P	anon	PRODOM_PD199303	Domain	This family is conserved in Proteobacteria. One member is annotated as being elongation factor P but this could not be confirmed. This domain is related to the Ribbon-helix-helix superfamily so may be a DNA-binding protein.	20.70	20.70	20.90	21.40	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.63	0.72	-4.20	9	66	2012-10-02 18:44:02	2008-07-31 10:43:35	3	2	66	0	20	44	4	81.70	67	73.33	CHANGED	hKKF....hlsC-FGGQpuPFs.lYIGpP+s-sHPlpaQssWLScERGGsIPpcVh-SLp+LacLAccNslsFt-LCVYALs............sApps	...............YKcF....EFDCDFuGQRAKFK.FYIGTPQEGHHPLQFQAKWLSDERGGTIPD-VMcAISQ.LNDLAKKNGVPLsDL....CVYALGsAQE.s...............	0	5	9	10
+10853	PF11021	DUF2613		Protein of unknown function (DUF2613)	Mistry J, Coggill P	anon	PRODOM_PD383784	Family	This is a family of putative small secreted proteins expressed by Actinobacteria. The function is not known.	21.70	21.70	23.50	23.30	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.60	0.72	-4.26	8	144	2009-01-15 18:05:59	2008-07-31 10:44:20	3	1	135	0	33	86	0	57.40	51	94.35	CHANGED	Ms........RhlsPAlASAVlGlsLGusAlhGlThhsppsopPsh.p.ussuDsulLspVEYGuR	..................M.RhluPAsASsVVGllLGuuAlFGlTLhsppDspPsl..s.uscssSS.VL.s..cVEYGsR.	0	5	20	29
+10854	PF11022	DUF2611		Protein of unknown function (DUF2611)	Mistry J, Coggill P	anon	PRODOM_PD055124	Family	This family is conserved in the Dikarya of Fungi. The function is not known.	20.40	20.40	26.30	25.80	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.52	0.72	-3.89	20	135	2009-01-15 18:05:59	2008-07-31 10:45:16	3	3	114	0	102	127	0	71.80	35	85.81	CHANGED	MGssYpIhG+pVsSHhLAluTLGolhu.slshsstGss.....ps....ssPsIsASSc........DEEKFIppaLtch.............ppcp	..MsshYpIhG+pVssHhLAhuTLGshhu..sshh.ussGsp.....................ptt......ssPPIsASSs.........................DEE...c...FI...pcFLcphctt.......pp...................	1	27	58	90
+10855	PF11023	DUF2614		Protein of unknown function (DUF2614)	Mistry J, Coggill P	anon	PRODOM_PD355753	Family	This is a family of proteins conserved in the Bacillaceae family. Some members are annotated as being protein YgzB. The function is not known.	19.90	19.90	20.00	20.20	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.66	0.71	-4.29	9	167	2009-09-14 14:03:03	2008-07-31 10:46:40	3	2	166	0	33	113	7	109.80	67	95.57	CHANGED	thKYSsKINKIRTFALSLVFlGhllMYlGlFF+sp.llMslFMlLGhLslIASTsVYFWIGhLST+AV.VlCPsCtK.TKhLGRVDhCMHCcpPLThD+sLEGKEFDEpYNp.....K	.............................u..KYSsKINKIRTFALSLlFlGhhlhY...l...G....l...FF...+...pshllMThFMhlG.hLulIASTVVYFWIGML.STKs....VQll.......CPSC-KsTKMLGRV..D.tCMHCNpPLTLD+sLEGKEFDEKYNKK.shp............	1	10	23	27
+10856	PF11024	DGF-1_4		Dispersed gene family protein 1 of Trypanosoma cruzi region 4	Mistry J, Coggill P	anon	Pfam-B_187 (release 23.0)	Domain	This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known. Other domains on this protein include DGF-1_N, DGF-1_2, and DGF-1_5. This domain is just downstream from the C-terminus, but not the C-terminus of proteins, also annotated as being DGF-1, that constitute family DGF-1_C.	20.90	20.90	23.60	23.10	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.89	0.72	-3.59	20	257	2009-01-15 18:05:59	2008-07-31 10:47:44	3	4	2	0	34	257	0	73.20	79	3.14	CHANGED	VDGCNRTPuMP.LSHTATLTETRShTPT......W....TPuh..STs+YSPTp.....YusTETLQVTETVALsPTRTPTA..SVSSTLWWSD	......VDGCNRTPuhP..LSHTAT..LTETRS.......T..P..T......W........TPSh.....SssHYSPTp.....YGPTETL......QVTETVALsPTRTPTA..SVSSTLWWSD......	0	0	0	34
+10857	PF11025	GP40		Glycoprotein GP40 of Cryptosporidium	Mistry J, Coggill P	anon	Pfam-B_197 (release 23.0)	Domain	This family is highly conserved in Cryptosporidium spp.  Many members are annotated as being a 60 kDa glycoprotein.	19.70	19.70	19.70	19.70	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-10.91	0.71	-4.68	11	884	2009-01-15 18:05:59	2008-07-31 10:48:02	3	1	25	0	1	890	0	141.60	80	54.38	CHANGED	EoTPKEECGTSFVMWFGEGTPVATLKCGuYTIVYAP.KDpTDPAPRYISGEVpoVTFEK..SDNTVKIKVsGpEFSTLSosSSSPTENsG.Sus.QspSRSRRSLoEEsuETsATVDLFAFTLpGGKRIEVAVPssc-suKRsKYSLVADDKsFYTGuNSGsosGlY+L	....EsTPKEECGTSFVMWFGEGTPsATLKCGsYTIVYAP.KDpTDPAPRYISGEVpoVTF-K..p-sTVpIKVsG.-FSTLSssSSSPTENsG..Sus...QspSRSRRSLo.EE....su..Es.ATVDLFAFTL.cGGKRIEVAVPssE-soKRscYSLVAsDKs.FYTGuNSGsosGlY+L....................	1	1	1	1
+10858	PF11026	DUF2721		Protein of unknown function (DUF2721)	Mistry J, Coggill P	anon	Pfam-B_520 (release 23.0)	Family	This family is conserved in bacteria. The function is not known.	28.30	28.30	28.60	28.50	26.80	28.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.53	0.71	-4.51	95	398	2009-01-15 18:05:59	2008-07-31 10:48:42	3	1	349	0	183	381	997	124.60	29	85.49	CHANGED	shssPshLlsuIuhLLhshosRhspl...ssphRpLp....sp..hcs.pps.th......ptpl....ppLc+.RhpLIppshhhushohllsslshhhlFl...........shshhsshlFshuhlhLhhuLlhhLhElpluspuLclph	.................hssPuhLhsAluhlLhuhoNRhhplsshlRpLp.............sp....hpp....stsshh..............ttp.lpsL++Rhpll+th.hhushShhlsslshhhlal............shphhsshlFshullhLlhoLhh.lhElploscuLclp........	0	49	119	161
+10859	PF11027	DUF2615		Protein of unknown function (DUF2615)	Mistry J, Coggill P	anon	PRODOM_PD288703	Family	This small. approximately 100 residue, family is conserved from worms to humans. It is cysteine-rich with a characteristic FDxCEC sequence motif. The function is not known.	20.80	20.80	21.20	34.70	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.84	0.72	-4.09	13	97	2009-01-15 18:05:59	2008-07-31 10:55:39	3	2	82	0	60	106	0	96.60	47	97.95	CHANGED	MuDs......FDsCECIaSHEtAMRRLlsLLRQSQuYCTDoEC.pDlPu.P..ptsusus...shhhlhhsWhllAhsLYlhRPs.....ohRssp......sssKPpsspsssuss...PPsPsls	......Mu-s..FDPCEClhSHEtAMRRLIslLR.QSQuaCTDoEChp-.lsG.P.......uu..sss.........shhhlh..hsWhllAhhLallRPs.....shRssp.........hss.KPssspssps...........PPsPs..s............................	1	23	28	42
+10860	PF11028	DUF2723		Protein of unknown function (DUF2723)	Mistry J, Coggill P	anon	Pfam-B_590 (release 23.0)	Family	This family is conserved in bacteria.  The function is not known.	24.20	24.20	24.30	24.90	23.80	24.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.09	0.71	-4.79	45	364	2012-10-03 03:08:05	2008-07-31 10:55:57	3	5	295	0	152	370	354	175.40	39	18.99	CHANGED	DsGEaIusuhpLtVuHPPGAPLahhlGph.Fohhs...huplAhtVNhhSuluSAholhhhaaslshLltc.h..............tphstsphhshhuuullGALAauFSDoFWFsAVEuEVYAhuuhh.sAllhalhLpWccph.ps.............css+WLlllualhGLSh.GlH...hhsLLslPAluhlaaa+ca.tploh+s	.....................................DsuEaIssuhcL.pVuHPPGAPhFhLl.up.......l..F.o.h.F....s.....pss....plAh...hV.N.hhSuLhSAsslhFLFaolo+Ls+c.hh.................t.pths.hsphlhlhuuGllGALsaoFSD.oFWFsAVE..uE.V.YAhuuhF.sAllhWL....hL+.....W.-c.tssps................cusRWllLIAalsGLSl.GVH...hlsL....L.s...lP...AIshlaa.a+ch..p.p...t......................	1	64	106	129
+10861	PF11029	DAZAP2		DAZ associated protein 2 (DAZAP2)	Pollington J, Finn RD	anon	PRODOM	Family	DAZ associated protein 2 has a highly conserved sequence throughout evolution including a conserved polyproline region and several SH2/SH3 binding sites. It occurs as a single copy gene with a four-exon organisation and is located on chromosome 12. It encodes a ubiquitously expressed protein and binds to DAZ and DAZL1 through DAZ repeats [1,2].	25.00	25.00	33.60	31.60	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.06	0.71	-3.71	9	94	2009-01-15 18:05:59	2008-07-31 11:08:40	3	3	68	0	56	93	0	128.90	44	53.94	CHANGED	YssAPPu...YpphYpsuashPPsA..ths.hsAsa....Pss.hhhP..stshslushuppsPMtaYPhG..........sVYPsGu..........TVhVpGG.aDAGARFGsGsu.s.oIPPPPPGpsPNAAQlAAMQGtNVlhTQRKsNaFhGGSsGGYTIW	...................................................................................................................PPs....Ypth..Ypss...as.h...ssss....thsthsush....Pu..ss.ha..hPh...spshsl....u..sh.up.s.....h.P..h...u.YY.PlG..................s....hY..PP...Gu..................olhVpuu..a.DAGARF.ss.u.us.sssIPPPPPGCsPNAAQLAsMQGtsVlloQ+KssFFhGGosGGYThW.....................	0	16	20	36
+10862	PF11030	Nucleocapsid-N		Nucleocapsid protein N   	Pollington J, Finn RD	anon	PRODOM	Family	This is the N protein of the nucleocapsid. The nucleocapsid functions to protect the RNA against nuclease degradation and to promote it's reverse transcription [1]. The NC protein promotes viral RNA dimerisation and encapsidation and initiates reverse transcription by activating the annealing of the primer tRNA to the initiation site [2].	19.60	19.60	22.00	26.80	17.30	16.70	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.20	0.71	-4.44	2	41	2009-01-15 18:05:59	2008-07-31 11:15:03	3	1	5	0	0	33	0	133.30	84	100.00	CHANGED	MNSMLNPNAhPhQPpPQVVAhPhQYP.GFpPtFRRpRNPGFRPMFpRR..NNuNQNRuRQsR.RlQNppRG..hNhpsstQRuNRRQ.NQ.S.slPFEQQLLMMANETAhuATaPPEhQslAPTKLVKIAKRAAMQIVSGHATVElSsGspDos++lATFTIKVshN	...MLNPNuhPFQPQPQVVAMPIQYPMGFQPRFRRRRNPGFRPMFQRR..NNSNQNRSRQsRsRIQNQRRG..lNoSRTQQRANRRQNNQQSLSLPFEQQLLMMANETALSATFPPELQSLAPTKLVKIAKRAAhQIVSGHATVElSsGppDos++lATFhIKVshN	2	0	0	0
+10863	PF11031	Phage_holin_T		Bacteriophage T holin	Pollington J, Finn RD	anon	PRODOM	Family	Bacteriophage effects host lysis with T holin along with an endolysin. T disrupts the membrane allowing sequential events which lead to the attack of the peptidoglycan. T has an usual periplasmic domain which transduces environmental information for the real-time control of lysis timing [1].	19.80	19.80	19.90	22.40	18.40	19.40	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.30	0.70	-5.19	5	43	2009-01-15 18:05:59	2008-07-31 11:27:23	3	1	38	0	0	44	0	200.40	49	98.42	CHANGED	scVStuh+u-lLhslLDRLFKDssoGclLlpRVhlllLLFlMAllWYsssElFuaYKco+YETYsEIlQsERsc+FEsAApEQLQIVHVSScADFSuVaSFRPKNLNYFVDlIAYEGKLPoTlsEKsLGGaPVNKTS-EYpVHLsG+HYsScp-F...AYLPo+ccohE...lsYMYSCPYFNLDNIYAGoIoMaW++KPc.Is-.....E+LssICNQAARILGRA+	.........................s-lLFGlLDRLFKDsuTGKVLhSRVhllllLFlMullWY+s-plhshYKpopapsYschlpp-+ss+F-ssAhEQLQIVHlSStADFSAVaSFRP+NlNYFVDllAYEG+LPsolscKsLGGaPlDKTSpEYpsHLsGppa.Sspch......saLPo+..c.s.c...hsYMYSCPaFNLDNlYAGoluhaWhc.c.Pp.lsp.......-+LpslCuQAuRhLGRs+...	1	0	0	0
+10864	PF11032	ApoM		Apolipoprotein M (ApoM)	Pollington J, Finn RD	anon	PRODOM	Family	ApoM is a 25 kDa plasma protein associated with high-density lipoproteins (HDLs). ApoM is important in the formation of pre-ss-HDL and also in increasing cholesterol efflux from macrophage foam cells [1]. Lipoproteins consist of lipids solubilized by apolipoproteins. ApoM lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide [2].	20.60	20.60	21.00	20.70	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.31	0.71	-4.72	4	77	2012-10-03 08:47:39	2008-07-31 11:35:15	3	2	40	5	37	102	0	164.30	37	93.66	CHANGED	MhHplWsaLLYLYulhhsSlu.CPu.s.LsssGlctppFPp.aLGpWYFlAuAA.PspctLATFcPlDNlhFshttuuss.pL.LRAsIRhKsGhCVPRcWhYhLscGsT-LRhEG+Pch+TpLFS...usCPcsIILKET..spuYpRhLLYuRpPpsstcsVp-FpshsuChsao.hL.hPppQ-ACploS	.......................................h..hh.hh.lhhts....C.....s.lss.shstpph...hLGpWaFlAuAu...spppLtphpshD..shhhshssuoss.pLplptslRhcpGhClscpW.h..Y.pLs..p..s..o.ss..L.p..h...E..G+.sc...h+spLas...ssCPss.IhLp.Eo.........spsapR....hL.LYsRsscss-cslEEFcuhspCLshc..thh.hP.ppthC.h...........................	1	1	3	18
+10865	PF11033	ComJ		Competence protein J (ComJ)	Pollington J, Finn RD	anon	PRODOM	Family	ComJ is a competence specific protein [1].	25.00	25.00	25.90	25.40	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.37	0.71	-4.49	7	123	2009-01-15 18:05:59	2008-07-31 11:38:10	3	1	121	0	16	69	0	128.10	58	96.00	CHANGED	M.......ELoISYpQhhlhph-upPPslDWTDEshE+GYApuDsAV.FEAlpshpspltlpLssphphtuh.RplTVPFpVtp-slhIpSlhSp+lphsIPpGcYpLsh.osP...spcs-Lat.pY.l.Fpsh	.............MELTISYSQLMLMNYDGEQPYVDWTDEDFERGYAcADGoV.IFEA.LSDY..T..CEVKVTsGKH..I.E..K.EEV.lRTloVPFTV.c.N.E.sIslTSILSN.K.FpIPIP.NGEYTVVLQAsPLEEPTDDELYKIQYEFFFES.K.......................	0	4	10	12
+10866	PF11034	DUF2823		Protein of unknown function (DUF2823)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins are possible glucose repressible proteins however this cannot be confirmed. Currently, no function is known.	25.00	25.00	34.90	32.90	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.23	0.72	-3.85	11	69	2009-01-15 18:05:59	2008-07-31 11:43:39	3	3	46	0	56	63	0	67.40	55	89.33	CHANGED	METlK....NAuNYVuEoVQuAsusASKEANKpVAKDSsAuluTRssAAtDAlsDKt-EppHDAKA-sHKpu	..................M-olK....pAuNYVoEpVQuAousASKEANKpVAKDS...sA...ulGTRsoAAtDAluDKhcEppH-ucA-saKpt...........	0	18	32	49
+10867	PF11035	SnAPC_2_like		Small nuclear RNA activating complex subunit 2-like	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is SnAPC subunit 2-like. SnAPC allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element [1].	21.50	21.50	22.00	23.60	20.40	21.40	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.03	0.70	-4.96	3	65	2009-01-15 18:05:59	2008-07-31 11:57:22	3	2	32	0	36	49	0	234.00	43	98.19	CHANGED	MKPPQRRRAlPARYLGEVTGPAAWSAREKRQLLRLLQARQGQPEPDAAELARELRGRSEAEIpcFIQQLKGRVAREAIQKlHPGGhcGPRRpETQsPAPIEVWMDLAEKITGPhEEALTVAFSQVLTIAATEPVSLLHS+PuKPTQARGKPL.LLSAPGGQEDPAPEuSSPAPtAPu.........sscssGSsP+TPG.......PAPEAPSESLAGsSTEcDFAVDFEKIYKYLSSVSRGG+GPELSAAESAVVLDLLMALPEELS+LPCTALVEHMTcTYt+LTAPQssLAGGuLu.PGTEDuGAGS+GPEETsQASPQAoEsAtpSEP+SuWQAAGICPLNPFLVPLELLuQAsoPAR	.................................................................................................................................................................ltsalp.LKt.sspEslpp...th..t.Rpppsp..APIElWhDLAc+lTGshEEulssAFSQhLTIuAsEPloLhaS......hPs+s.spsps+.h..hp.s.t.ppp.ss..sts...s......................................................................u.ss.s...hp....ph..........VDFEKIYKYLSphu+sspuspLS..s.s..ESAVlLcLLMuLPEELshLPCssLhcHhhpsYhpL..hu..Pp.s....ust....s.s....sss...Essssssp.s....pps.....s....s.......st.s.................p.....hptht......hs.PLNPFhlPLphLtp.........................................	0	1	3	9
+10868	PF11036	YqgB		Virulence promoting factor	Pollington J, Finn RD	anon	PRODOM	Family	YqgB encodes adaptive factors that acts in synergy with vqfZ , enabling the bacteria to cope with the physical environment in vivo, facilitating colonisation of the host [1].	20.10	20.10	22.90	50.00	18.50	15.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.18	0.72	-4.45	2	382	2009-01-15 18:05:59	2008-07-31 13:08:21	3	1	379	0	6	24	0	43.00	84	96.41	CHANGED	MKKKPVAQhE+Q+.LLENPhsYGLLSphphAIVVNCFTLsph.	MKKKPVAQhERQHoLLENPCAYGLLSQFQAAIVVNCFTLNKII...	1	1	1	3
+10869	PF11037	Musclin		Insulin-resistance promoting peptide in skeletal muscle	Pollington J, Finn RD	anon	PRODOM	Family	Musclin is a muscle derived secretory peptide which induces insulin resistance in vitro. It encodes a 130 amino acid sequence including a NH(2) terminal 30 amino acid signal sequence. Musclin expression level is tightly regulated by nutritional changes [1,2].	20.70	20.70	22.40	21.60	18.20	17.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.61	0.71	-4.53	3	49	2009-09-11 15:35:46	2008-07-31 13:09:12	3	1	36	0	27	34	1	123.70	65	94.62	CHANGED	MLDWRLASVHFILAlTLMLWuSGKVLSsDlAocsF-.StslulpuPPTAoEEKSAT-LAAKLLLLDELVSLENDVhETKKKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKKRFGIPlDRIGRNRLuNSRG	...........MLDWRLsusHFI....LAlo.LhhWSSGKVlSs-ss.o.E.A...FD....SullclQS.sPTsp..EEKSATDLsAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHK.GKQRKsV-hPKRRFGlPhDRIGhNRLssoRG..........................	1	1	3	9
+10870	PF11038	DGF-1_5		Dispersed gene family protein 1 of Trypanosoma cruzi region 5	Mistry J, Coggill P	anon	Pfam-B_157 (release 23.0)	Domain	This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known.  Other domains on this protein include DGF-1_N, DGF-1_2, and DGF-1_4. This domain is just downstream from the C-terminus, but not the C-terminus of proteins, also annotated as being DGF-1, that constitute family DGF-1_C.	25.00	25.00	39.10	39.10	17.90	16.70	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.88	0.70	-5.19	3	286	2009-01-15 18:05:59	2008-07-31 13:12:31	3	5	2	0	52	286	0	248.30	89	11.79	CHANGED	AGGSLT.sDIRso.....GuAVPc+LhVALPPPFR..WARDPQLGTHLoF.shsSpuQPsGauGPWGE.MLRNATWVRNATNPSTVLELAVPVHRGYFIGADETIVIRCDAVAVaGGCKGVLLGuFTIsSNTPPAlASALSAITGVVAGAAAVAVVVTGGLGSILEMQALGVFARMSCASAQERASTVALPYFLSVFAALDPLWMVVGNALLAAVFGCVHYGVTAAFQRWRGVDAASAWAAMRFPSLTYVVAHAMHLGIFFGSVFALAMPGARVQHYVIGVVGVLYG	....AGGSLTQNDIRGG.....GSAVPThLMVALPPPFR..WARDPQLGTHLSF.VPVSTAQPpGFGGPWGA.MLpNATWV.RNATNPSTVLELAVPVHRGYFIAADETIVIRCDAsAV.GGCKGVLLGSFTIRSsTLPAAASALSAITGVVA.GAAAVAVVVTGGLGSlLEMQALGVFARMSCASAQERASTVALPYFLSVFAALDPLWMVVGNALLAAVFGCVHCGVTAAFQRWRGVDAASAWAAMRFPSLTYVVAHAMHLGIFFGSVLALAMPGARVQHRVIGVVGVLYG...............	0	0	0	52
+10871	PF11039	DUF2824		Protein of unknown function (DUF2824)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function. Some members in the family are annotated as the P22 head assembly protein gp14 however this cannot be confirmed.	25.00	25.00	25.00	25.20	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.87	0.71	-4.49	3	167	2009-01-15 18:05:59	2008-07-31 13:13:44	3	1	163	0	4	76	0	148.80	65	99.31	CHANGED	MITFpPTRNIDLIEMVGNHPDIIAGSNNGDGYDYKPECRYFEVNVHGQFGGIVYYNEIQPLTFDCHAMYLPEIRGFSKEIGLAFWRYILTNTTVQCVTSFAARKFRHGQMYCAMIGLKRVGTIKKYFKGVDDVTFYSATREELIDFLNHGR	........................MIpFpPTRNIDLIEhVGNHPDIIAGSNNGDGYDYKP-CRYFEVNVHGQFGGIVYYpEIQPL...TFDCHAMYLPEIRG.FSKEIGL.AFWRYILTNTTVQCVTSFAARKFRHGQMYCAMIGLKRVGTIKK.YF.K.G..VD...DVTFYSATREELIDFLNHGR......	0	1	1	1
+10872	PF11040	DGF-1_C		Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus 	Mistry J, Coggill P	anon	Pfam-B_30 (release 23.0)	Domain	This protein is likely to be highly expressed, and is expressed from the sub-telomeric region. However, the function is not known. This is the very C-terminal part of the protein.	25.00	25.00	49.90	48.00	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-9.84	0.72	-4.09	26	256	2009-01-15 18:05:59	2008-07-31 13:20:46	3	4	2	0	31	256	0	80.50	80	3.82	CHANGED	WYAEDRHWQELREPRRGGLEALLRDDEESDE-TQKPH-hTSSSYASGTTsASSYRPPAP.....................QPMAGDTRSDALSLhDRASSASspIs	.WYAEDRHWQELREPRRGGLEALLRDDEESD.EETQKPH.-.MTSSSYASGTTVAS.SYRPPAPP.....................QshAGDTRSDAhSLhDpuSoAut.l............	0	0	0	31
+10873	PF11041	DUF2612		Protein of unknown function (DUF2612)	Mistry J, Coggill P	anon	PRODOM_PD048079	Family	This is a phage protein family expressed from a range of Proteobacteria species. The function is not known.	22.90	22.90	23.00	23.70	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.80	0.71	-4.72	18	287	2009-01-15 18:05:59	2008-07-31 13:21:32	3	2	240	0	38	254	0	165.80	26	78.34	CHANGED	shtshllhQYpspP+hhuhlpthtshh.sshhphlss.lsslaDlDsAsGhtLDllGchVG.luRhlps....t.aFuF..shtuhsa.......stu.ahs.hcstsssstLsD-sYRhLI+sKlhpNhhcsTlsslsshhp.lFuss...sallDshDMo..hsssVssphhoshhhtllpphsllP+PsGVplpa.ll	..........hhthlhspatspPph.shlphhsp.h..sstshhps.h.phaslDoA.GhtLDlhGphlG..hsRhls...s...t.ahua.....s...t..s.hsa..................spus..a...s.s.p.s..s.ss.......htLsD-tYRhll+sKhhtNhh.cuossslsthLchhassp...phhlh....Dst-Mo....hhlh.p....t..hssh...ph...thlpp....h.....lh..s+ssGV.h.....h..........................................	0	3	17	27
+10874	PF11042	DUF2750		Protein of unknown function (DUF2750)	Mistry J, Coggill P	anon	Pfam-B_609 (release 23.0)	Family	This family is conserved in Proteobacteria. The function is not known.	21.60	21.60	22.10	21.80	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.36	0.72	-4.01	71	710	2009-09-11 13:47:04	2008-07-31 13:22:01	3	2	507	0	130	400	30	105.20	33	68.29	CHANGED	RhphFl..pcltpppplWsLpcccG..alhhsos-t-s........hPlWsscchApt..asss-WpchpstsIsLscah-pWlssLpcDslhlul...stsp.pGhhlpPp-lsppLt	.........RhphFl..p-ltcpppVWuLpccpu....alhlsss-p-p.........hhPlWsp+ptApt..hss..-..-...Wt.-h.cshsIshshFhEtWLssLc-Dsht.Vu.lsh.sssh..GhllpspcLsp-L..................	0	27	54	99
+10875	PF11043	DUF2856		Protein of unknown function (DUF2856)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this viral family of proteins with unknown function are annotated as Abc2 however this cannot be confirmed.	25.00	25.00	71.00	70.90	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.19	0.72	-3.87	3	202	2009-01-15 18:05:59	2008-07-31 13:23:26	3	1	181	0	3	78	0	94.10	88	99.85	CHANGED	MPAPLYGADDPRRCSGNSVSEVLDKFRKNYDtIMSLPQETKAER-FR+sIWLAEKpEKERIpQTSIRPFRKATYTKFIE.IDPRLRNYRSRYGAISNN	................MPAPLYGADDPRRCSGNSVSEVLDKFRKNYDhIMSLPQETKEEKEFRHCIWLAEKEERERIYQTSIRPFRKATYT+FPE.IDPRLRNYRSRYGAISND	0	0	0	0
+10876	PF11044	TMEMspv1-c74-12		Plectrovirus spv1-c74 ORF 12 transmembrane protein	Mistry J, Coggill P	anon	PRODOM_PD019016	Family	This is a family of proteins expressed by Plectroviruses. The plectroviruses are single-stranded DNA viruses belonging to the Inoviridae. Except that it is a putative transmembrane protein the function is not known.	20.80	20.80	20.80	22.00	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.45	0.72	-4.41	4	35	2009-01-15 18:05:59	2008-07-31 13:24:13	3	1	6	0	0	33	0	48.60	76	87.95	CHANGED	MPTWLTTIFSVVIlLulFhahGL.IYQKIRQIRGKKK-KKEIccKEspc	....MPTWLTTIFSVVIlLGIFsWIGLSIYQKIKQIRGKKK-KKEIE+KEspK...	0	0	0	0
+10877	PF11045	YbjM		Putative inner membrane protein of Enterobacteriaceae	Mistry J, Coggill P	anon	PRODOM_PD079046	Family	This family is conserved in the Enterobacteriaceae. It is a putative inner membrane protein, named YbjM, but the function is not known.	25.00	25.00	31.30	30.70	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.78	0.71	-4.36	6	477	2009-01-15 18:05:59	2008-07-31 13:25:27	3	1	474	0	30	104	2	118.90	78	99.49	CHANGED	MtppphWhuhhsCFlLF.lVhL..thtspGuFc.uuG+sElGLLhFlLPGAVASahSpR+RlL+PLhGAllAAPlCLllh+LahsPsRSFWQELAWlhSAVFWCuLGALCaLFlpoLhpthRp+..pR	..........MKHKptWAuslCCFVLFIVVCL.Ls..hHM..KGAFR.AAGHPEIGLLFFILPGAVASFFSp....RREVLKPLFGAMLAAPCSMLIMRLFFSPTRSFWQELA.WLL.SAVFWCALGALCF.LFISSLFKsQHRKN.Q......	0	1	5	17
+10878	PF11046	HycA_repressor		Transcriptional repressor of hyc and hyp operons	Mistry J, Coggill P	anon	PRODOM_PD091544	Family	This family is conserved in Proteobacteria. It is likely to be the transcriptional repressor molecule for the hyc and hyp operons, which express, amongst others, the protein HycA. This protein may be harnessed for the reduction of technetium oxide, an unwelcome product of radio-nucleotide bioaccumulation. HycA produces formate hydrogenlyase, one of the key proteins necessary for metal compound reduction [1].	25.00	25.00	91.40	91.30	21.50	19.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.85	0.71	-4.26	4	465	2009-01-15 18:05:59	2008-07-31 13:26:04	3	2	462	0	21	85	0	147.90	88	96.20	CHANGED	MTIWEISEKADYIApRHRpLQ-QWHhYCNSLVQGITLSKARLHHAMSCAPpc-LCFVLFtHFtIaVsLA-GFNSHTIpYaVEsK-Gp-+pLIAQAQLshDGhlDG+Vs.RDR-QVLEHYL-KIAsVYDsLYsAlEpDhPVcLSpLlhuc	..MTIWEISEKADYIAQRHRRLQDQWHIYCNSLVQGITLSKARLHHAMSCAPDKELCFVLFEHFRIYVTLADGFNSHTIEYYVE..TK...DGEDK...Q.R...IAQAQLSIDGMIDGKVNIRDREQVLEHYLEKIAGVYDSLYTAIENNVPV..NLSQLVKGQ........	0	1	3	12
+10879	PF11047	SopD		Salmonella outer protein D	Pollington J, Finn RD	anon	PRODOM	Family	SopD is a type III virulence effector protein whose structure consists of 38% alpha-helix and 26% beta-strand.	25.00	25.00	27.20	26.00	24.00	23.00	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.79	0.70	-5.47	2	272	2009-01-15 18:05:59	2008-07-31 13:26:32	3	6	136	0	9	152	0	274.40	60	89.82	CHANGED	MPVTLSFGN+pNYplNcSRLA+LhSsDKEcAlaMGsWD+hpDpFRscKKpcsLEVLaolIHGptRtp.uEhpVslpshpKIaAFppLpchAsPupQDhFsh+hDhsQTQhLh.lsspVIspsNl+clLNlS-sslhcsMpc-EcpLFLpIC.hhGtKhohaPELLpt.hspL+ctVstssplKstVYchMRsuEs.ch.hVEWpsoLTE-EKshLtClphGsFp.TTQFhKIGY.ElpGEVhFsMhHPslSYLLpsYpP...u-hh.TNoh.F.chLNpDYsDYpspKh.IDsILc+lYhoHppoLaIuccussRNhLl	..............MPVTLSFGN+p.NYplNcSRLA+L..hSuD.K.EcAlaMGsWD+hpDpFRscKKpcALEVLaolIH...Gp.GRtc.uEh-Vsl-shs..K....IaAFc+LpphAsP...up..QDhFsh+hD.ho..Q..T...QhLhhlsspVISpsN.l+..clLNlSDssVlcsMsc-EcpLFLpIC.hhGtKhoh+PELLQp.hspLRctVstsspIKstVYchMRPuEs.chshVEWpsoLTtDEcshLsClphGsF-.oTQFhKIGY.El.pGEVhFsMhHPsl.YLL+uYpP...s-Fp.oNoh.F..chLNpDYsDYpspKh.IDsILc+lYhoHppoLaIucsussRNhLl.....................................................................................	0	2	3	5
+10881	PF11049	KSHV_K1		Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus	Mistry J, Coggill P	anon	Pfam-B_38 (release 23.0)	Domain	This is a highly glycosylated cytoplasmic and membrane protein similar to the immunoglobulin receptor family that is expressed as an inducible early-lytic-cycle gene product in primary effusion lymphoma cell-lines. This domain would appear to be the cytoplasmic region of the protein [1].	20.90	20.90	21.30	43.00	20.40	16.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.59	0.72	-3.99	13	1340	2009-09-11 12:24:34	2008-07-31 13:28:52	3	4	3	0	0	1052	0	67.90	71	41.93	CHANGED	YTLTCPSsASLPISWYCNsTRLhRL.Tsp.TlTl.ss.lTCNFTCVsQSGHpHSIWIpWasQPVLQTLCAQPSNT	.YTLTC.SssSLPISWYCNsTRLhRLTpp.olTV...so.l.s.CNFTCVpQSGHRpSIWITWasQPVLQTLCAQPSNT................	0	0	0	0
+10882	PF11050	Viral_env_E26		Virus envelope protein E26	Pollington J, Finn RD	anon	PRODOM	Family	E26 is a multifunctional protein. One form of E26 associates with viral DNA or DNA binding proteins, while a second form associates with intracellular membranes [1].	25.00	25.00	69.30	69.20	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.53	0.71	-5.13	8	16	2009-01-15 18:05:59	2008-07-31 13:29:20	3	1	13	0	0	16	0	186.80	49	99.87	CHANGED	MEosp.....lsssaAs.K..tuAlss.....hV+TVVTTTssSspstsp......cs+IsQlIAQLp+TRLsFsKLopLQ+KRVRNMQ+LlRKKNplIAsLAApLpsppp........+...sKaFAVshsKNllhThSGSEpFVRpRVA-LCAh.GGEQVFCuRRADCARDRpRlAcALssSLGuGVlspusNKRFEIh-s-KlVSAKLIlQQVLHDGhcuDssAa	.........MEosp....h.sstaAs.K.pthAVss....ohs+TVsTTTssSshscp.....-ppp+IsplIupLppT+LsFsKlpplp+K+lRphQpLlRKKNpIIAsLstpLpstpc................hKaFuVshscNslhTh.GsEpFVRpRlA-LCsh.suE.VFCttRsDss+DRptlAphLssuhGutVlshtsN+RFEhlps-clsSuKhll.phLpDt.puDhsAa.....	0	0	0	0
+10883	PF11051	Mannosyl_trans3		Mannosyltransferase putative	Mistry J, Coggill P	anon	Pfam-B_379 (release 23.0)	Family	This family is conserved in fungi. Several members are annotated as being alpha-1,3-mannosyltransferase but this could not be confirmed.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.95	0.70	-5.05	117	725	2012-10-03 05:28:31	2008-07-31 13:29:41	3	19	160	0	543	759	22	250.80	23	44.84	CHANGED	u+GIVhsu.......Gs...th.hh.h.thl+hLRp.hG.....spLPlEllh.s..s-h..spchppplls............................................hls....spsllhsshhsp.hh...........................s..ap.......hKhlAllhSSFEcllhLDADslslps.P-p.hFp..scsappsG.hlhW...-hhppshsshhhplhs.....................h.....tt...t.......................th.hpph.sth.ptssESG.llls..Kp....pHhpsLLLuhaaN.hasss.......hha.hhs.G......D.....KEoFhhAshhh............................s..psYa.spp.ssslGhhst..........................................p.phs.usthuphD	............................................................................................................tcGIVhss.........us....phh.hsh..thl+hL.Rp.hG.....spLPlElhhhs..s.-h.......spphpptlhs................................................h.ls...........sp..s.l..hh..p......phhsp..hh....................................s.ap....h.KhhAll.hSoF-c.llhLDuDslshp....s.Ps.........h.lFp................sp.sap..ps.G.hlha........s.....hh..p..p...p..h....tshhhp.lhp.........................................................................................tth.tth...phptESG.llls..Kp....p..H.h..ts.Lllshahs..hht.p........h.h...h.hs.G.......DKEhFhhuhhhh............................s...psahhspp..s.ssh.Ghhpt.......................................................thpu.thhphs.................................................................................................................................................................	1	117	294	503
+10884	PF11052	Tr-sialidase_C		Trans-sialidase of Trypanosoma hydrophobic C-terminal	Mistry J, Coggill P	anon	Pfam-B_103 (release 23.0)	Motif	This is a highly conserved sequence motif that is the very C-terminus of a number of more diverse proteins from Trypanosoma cruzi. All members of the family are annotated putatively as being trans-sialidase but this appears to be a diverse group.	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.89	0.72	-7.06	0.72	-4.06	45	797	2009-01-15 18:05:59	2008-07-31 13:30:14	3	9	3	0	143	798	0	24.70	62	3.66	CHANGED	uuos+GsshL...LLLL..LLGLWG..hAAl	...uuTs+G..us..lL..PLLLL..L.L.GLWG.FAAL.....	0	0	0	143
+10885	PF11053	DNA_Packaging		Terminase DNA packaging enzyme	Pollington J, Finn RD	anon	PRODOM	Family	Phage T4 terminase functions in packaging concatemeric DNA. The T4 terminase is composed of a large subunit, gp17 ad a small subunit, gp16. The role of gp16 is not well characterised however it is known that it binds to double-stranded DNA but not single stranded DNA [1].	25.00	25.00	30.30	29.60	19.80	18.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.91	0.71	-4.61	7	72	2009-01-15 18:05:59	2008-07-31 13:33:08	3	1	69	15	0	59	837	144.80	36	88.29	CHANGED	MsD..L.DhspLhDlsu..lPG.lpuE-spV.YpPlVLp-VcSpPpsRshDL-cDYslVRcNhHFQpQMLMDhAKIhLEsAKNu-SPRahEVFusLMsQMTssNKElL+lHK-MK-IT.pphtp...uupsshpsplQNssl.....FhGSPs-Lh-.ElGD..p.	.................................................htt....G....s.p.....apP......l..lpSp....P...p.s...cssDlcpDYphsRpshH.hQpphhh-AuchhLEsA+so-uPRthEVFupLhpphssssccLlcLpKcMK-los-p..t.p..ts.ssspsshpNs.Tl.....FhG....Sss-Lhc.plts..........................	0	0	0	0
+10886	PF11054	Surface_antigen		Sporozoite TA4 surface antigen	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins is a Eukaryotic family of surface antigens. One of the better characterised members of the family is the sporulated TA4 antigen. The TA4 gene encodes a single polypeptide of 25 kDa which contains a 17 and a 8 kD polypeptide [1].	25.00	25.00	63.50	63.40	18.30	17.90	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.83	0.70	-5.00	12	29	2009-01-15 18:05:59	2008-07-31 13:51:46	3	1	2	0	0	29	0	240.70	41	97.62	CHANGED	hshhsllpsSLLhlu.s..GputssttsspYTAshGtslpCLuElNuARcAAGLssFt-A.ossppLscPssp-h....psuopW+.clCcaLlP..ps-ssstusshpPFptGTYAFKsLTsspssCK-sV-YWKuAacNFoG.LPPocspuss..lYssQpNVSFVALYNPpusAoADCpVVTCTpssssss..........ussplpu-stpt.........spsGaAlICKThPuAF.s-sosPFTp-QWcKIVsSLTGS........sSsshPSlsshhIsshuhhuL	......................h.h.sllphSLLhl.s.....upptsptttsphTAs..tslcCLsEhNssRcAAGLssFtp.A.sssthLspsuspph.....psso.Wp.clCptlls..pscss.spssshs.F..GTaAatslTsspssCK-sV-YWKuAacsFsG.LPPohptsss..lYscppsVSFVALYNPpssss.AsCtllTCTpssss........................ussplpu.-sttt.........sppuhAllChT.PsAh.sssosPFTp-QWcKIlpSLoGS........sSsssPolsshhlsshuhhuL.....	0	0	0	0
+10887	PF11055	Gsf2		Glucose signalling factor 2	Pollington J, Finn RD	anon	PRODOM	Family	Gsf2 is localised to the ER and functions to promote the secretion of certain hexose transporters [1].	25.00	25.00	46.40	46.30	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.29	0.70	-5.94	9	45	2009-01-15 18:05:59	2008-07-31 14:01:25	3	1	44	0	29	42	0	367.10	46	95.97	CHANGED	hElYlRhNDDhE+DYsFQlcpscThcs.lhKIFs.......oh.hsLRPSlFacscPlGFpKSspPGYLTEsGsLlFcY-Ascpcahcpls..cchlh-plWPGQLILPhWchsphshasFlslhlsWLYTDLPDhISPTPGICLTNQLSRhhh.lAppash.clAppLht-lp.s.sulsAQhLFFlhHllKllhIhhhhYhGhhNPlphN.aphhsh+pph..................hKcpLhslGWhGARRAThD-Yp-hYhpYtIccaGGhlpAaRA..Glhcphts.GlpLusGEGFpTPL-c+hThsThpshcpct.....KFhLS.-YFspLtpshcp.l-cpsG..uchsspI+pFRRaGlhcss-clpclVphRKthsspcc..............p.KhE	.MEIYlRhNsDhE+DYsFQVss-cThps.lhKIFs............u..hsLRPSIFacpcPltFhKShpPGYLTEsGsLlFcY-Aspcc.lppls.csc.lh-plWPGQLllPcWchschshasashlhLsWLYTDLPDhISPTPGICLTNQlSRhh.h.lAcp.hshsclAs+LtpElp.s.sulsAQhlFFlhHlhKlslItLFLhhGlhNPISFNshphhs.l+s.s.......t.............s.hKppLpolGWhGA+RAThD-YpspYhsYhIcKhGGhVtAa+A..GhhcphtssGlpLssGEGFpTPL...-c+.aTtsTFpsl.cp-t.......KFlLS.EYFlcLppsL+c......l...-ch-G..-l....uchNtpI+cFRRaGlaEss-+ltplVphR+phscp.p.............pppt.................................	0	4	15	26
+10888	PF11056	UvsY		Recombination, repair and ssDNA binding protein UvsY	Pollington J, Finn RD	anon	PRODOM	Family	UvsY protein enhances the rate of single-stranded-DNA-dependant ATP hydrolysis by UvsX protein. The enhancement of ATP hydrolysis by UvsY protein is shown to result from the ability of UvsY protein to increase the affinity of UvsX protein for single-stranded DNA [1].	22.80	22.80	24.80	27.40	22.20	22.70	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.45	0.71	-4.01	9	67	2009-01-15 18:05:59	2008-07-31 14:03:14	3	1	65	0	0	59	954	129.50	31	92.29	CHANGED	phccDhhID........sopLppEuhc.PhLauKWLphaoshpp.hhclEhpt+pslK-Rh.aYoG+u-..sEVsh-h.....hcpS.ElKhslsuD-cllclssplpYhphlhcFhppuLctlpsRGFsIKshIEhR+hEuGt	........................hcpD.hID........sspLp.-uhp.shLasKahchasshpphhhplEtchKphhKp+hpYYsG+us..sphhh-p.....hppo.ElchhlsADc-ll+lssplpYhphllcFhcssLctIpsRuapIKNhI-h++FpsG...	0	0	0	0
+10889	PF11057	Cortexin		Cortexin of kidney	Pollington J, Finn RD	anon	PRODOM	Family	In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species [1]. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex [2].	25.00	25.00	47.50	47.30	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.90	0.72	-4.38	5	92	2009-01-15 18:05:59	2008-07-31 14:10:38	3	1	36	0	63	63	0	80.10	57	97.67	CHANGED	Msosasl.PSPss.............................................sSussluusSLoLEQKTuFAFVGlLhlFLGLLIVRCFRILLDPYSSMPoSSWsDclEGLEKGQFDYALs	........................Msus.sh.spsh...............................................ssssssssul....oLEQKTsFAFVhlLhlFLGlLIVRCFRILLDPYSSMPoSTWsDphEuLEKGQFDYALs......	0	3	8	22
+10890	PF11058	Ral		Antirestriction protein Ral 	Pollington J, Finn RD	anon	PRODOM	Family	Ral alleviates restriction and enhances modification by the E.Coli restriction and modification system [1].	25.00	25.00	84.80	84.70	21.70	16.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.53	0.72	-4.60	2	90	2009-01-15 18:05:59	2008-07-31 14:13:30	3	1	82	0	1	27	0	53.70	89	99.79	CHANGED	MTTTIDTNQWCupFh+CpGCKLpuECMVKPEEMh.VhEDGKhVDKWAIRTTtMIARELtK...KAh	...........................MVKPEEMFPVMEDGKYVDKWAIRTTAMIARELGKQNNKAA.....	0	0	0	0
+10891	PF11059	DUF2860		Protein of unknown function (DUF2860)	Pollington J, Finn RD	anon	Pfam-B_002667 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.30	21.30	21.30	22.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.60	0.70	-5.37	29	262	2012-10-03 17:14:37	2008-07-31 14:23:33	3	1	230	0	25	207	14	288.20	40	91.00	CHANGED	GFSGplolhsGhsuspSsh.....ss.psssphssh..ssuupocosslshPLGslpYTFupt.spQlFhGsscsDlhsGphthElGYcpphssssslshShlPslhp.sEsWpDPYhssssRppTDhsspuhRlphpplhs..usasl-hAaucp-lDpEpou.................ts.LcRsuphahhchsYphsL..spshhLpPulsYtppDADGcAhSaspaGsplohhhhhscHplslThuhupppYDu..sNPIFs+s.p--sphuhhhsYpYpshasacshuhsuhsGaspscSNIsFYDpsphllSlGlsYp	...............................................................................................GaSGsLSlssGhtcsKSNh.....sT..ssssh..losh...sus.sS-oshlsh.huplhYs.h.s.NsplFhts.sscslsG...htLGYc+ta.cthshohShlsSLh..pcsatsPYhhss.RppTDlst.GaRlu.hh..s..stFoh..sYsau..cpKlDc-p.u.................pupLpR...-upYaplchsYshuL.......Ls.ulsYs.pDAD...GcAp..SaopaG..aplGsph.h.F.u.p...s.hh.lT..suhuhpcY-s..scP...IFsKp.pDu..shhph.hthV...hpphhGapsl.hhu.hGlpcpsSs.I.s.FYDpp.pll.TGluYp..............	0	6	14	20
+10892	PF11060	DUF2861		Protein of unknown function (DUF2861)	Pollington J, Finn RD	anon	Pfam-B_002683 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.00	48.60	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.57	0.70	-5.04	43	183	2009-01-15 18:05:59	2008-07-31 14:27:32	3	1	112	0	17	107	0	251.20	41	89.45	CHANGED	WFcs.TPLppuaQtLlEschsphappLlcshppsP...lppph.pLltpul..pspCG+uLsspshsDhh.uVThh+phsQo.tt.ph+Luh-shTps.lscls.sp..ssplluu-.uhs...........ttpYs.scphsLhuPhuAGlYpLolsspc.t.......lllusssupphlc.o...Spc-apIchsAh.supsP....SluhapahDtNap.l...............aSpThcsD.Psuh.ssshPSptahlolSlIppcaQGsItlEQhQplohshD	...WFcp.TPLppuaQpLLpschpphappLlcshphp....lpspL.phlhpul..pssCG+uLs.sp.shPD.WlpuVT..lhRp.lQSssp.th+lul-stop...s....l..sclphoph.sspllus-suhs..........ts.Ys.scphsLhsPhuAGlYplslsstctt...a.tWllluss.upphlcWo...Sc..c...-.apI.pp..sshhsupCPhPphSlula.sahDsNYp.l...............WSpoh...cs.DhPs..s..L...ssslPSspahloVShIppRaQGsltlEQ.QhIohshD.................	0	3	6	13
+10893	PF11061	DUF2862		Protein of unknown function (DUF2862)	Pollington J, Finn RD	anon	Pfam-B_003005 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	26.50	33.20	23.50	21.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.90	0.72	-4.26	26	91	2009-01-15 18:05:59	2008-07-31 15:02:59	3	1	73	0	34	85	165	61.70	46	76.61	CHANGED	IGpKV+..l..s+l+DRlspcllctltppshGplpsaKhsDGpGlGllVcLssGppsWFFEDElp.	.IGpKV+..V..pRlRDRlsspllcpLsp..hGslpsFKhTDGp.GIGllVchs.D.ssssWFFEDElc...	0	5	22	32
+10894	PF11062	DUF2863		Protein of unknown function (DUF2863)	Pollington J, Finn RD	anon	Pfam-B_002981 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	26.60	26.30	24.10	23.00	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.10	0.70	-6.38	12	116	2009-01-15 18:05:59	2008-07-31 15:34:25	3	1	112	0	44	96	40	389.90	56	97.80	CHANGED	t+hRsppps+Lu.-ApcLlsLAhuLstSGSRlEDtaWEppLsttls+LL+suspssL-AALDHLaptsssAY-.LA-tsEohuESh.lppsGtcaDlLLlAAPlLAWoRYpIPoGsl.sshhpsLtspLQuHVLAsss+lALssaLaS.DQLPRoaspThpLspcLupAALsup.sl+lphpshPETushLuDsRYLlAulusPpGpPlFRWQEpsps............pR-tsLtpWppQutssLusLLPGCthElLLPDAYasusRpAD+psRPhSlRAuVsaLpssLshssspL+AVluuFsEc....plEEYRIGFTh+sps-VlYGlVWPLhGp-......................u-s-sssslppIpAlL+EsGVp-lhphsthFs.EYC-DCGAPLaPs.pGElVHAEhPE-.u.sss.ph	...............................................h...Rp+tupRLsPDA-+LVuLuLALhASG.SRlE.DpaWEs+LsshLuKll+NGsQosLDAALDHLtpscs-.AYssLA-hAETtSEShslE....+.-...G..p..YD........ALLlAsPlLAWTRY..hI..P..SGslKs-lspsLpsHL.QAH.VL.AssspVAlAPaLYSIDQLPR.pHs.......-TapLsp.........pLApA.ALusp.ss......KlshsDhPETuPILA.D....P.....RaLLAlVuAPt.GtPLFRWQE-pcs.........p+..hERspCLEQWssQusssLushL..PG.......CEFEs..LLPDAYasACR-ADcRlRPhTVRsAlpYLhsTlu.ssPpcLRAVlAGFGEc....RIDEYRVuFTtRGS.sDVIYGlVWPLYGREsGps............p.puEss.suPLEEIsuLL+EsGVoDlRRHuu+FEPEYCDDCGsPLYADPhGEIVHAEMPED.AssuQPHF......................................................................................................	0	6	22	32
+10896	PF11064	DUF2865		Protein of unknown function (DUF2865)	Pollimgtom J, Finn RD	anon	Pfam-B_002953 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.90	19.90	38.80	33.00	18.00	16.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.87	0.71	-4.22	28	141	2009-01-15 18:05:59	2008-07-31 15:47:56	3	1	83	0	72	148	4	114.00	35	34.84	CHANGED	GuspshCVRoCDGhaFPlsttsssush......ptCpuhCPuucsclah....sssshctAsuhsG.csYuchPsAFtYRpphs...ssCoCpsts.s....uhu.hshpscsohct.GDllsopsuh	......shpshCVRoCDGtYFPluhssssuc..h.t....ptCpuhCPuucsplYh....s........upshctAsuhsG.csYssLPsAFtYRpphs...ssCoCpsts.s.....u.u.hs.hppcs.s.h.ct.GDllsstptt.........................	0	12	29	41
+10897	PF11065	DUF2866		Protein of unknown function (DUF2866)	Pollington J, Finn RD	anon	Pfam-B_002950 (release 23.0)	Family	This bacterial family of proteins have no known function.	25.00	25.00	29.80	32.10	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.43	0.72	-4.05	9	112	2009-09-11 09:26:37	2008-07-31 15:52:26	3	1	56	0	28	74	3	63.30	54	73.21	CHANGED	hslpuCRVSsPlppPWGtuhRlVEW.hctsuphpRRVVss-uTstElstsltpHV.GR+athsss	..slpuCRVS.shppPWGtshRlVEW.hchDuphtRRlVss-sTEAElstsltp.V.GR+Yhh......	0	2	4	14
+10898	PF11066	DUF2867		Protein of unknown function (DUF2867)	Pollington J, Finn RD	anon	Pfam-B_002931 (release 23.0)	Family	This bacterial family of proteins have no known function.	20.90	20.90	20.90	21.00	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.65	0.71	-4.48	57	1086	2009-09-11 16:38:42	2008-07-31 16:01:40	3	3	983	0	243	790	164	137.50	35	34.25	CHANGED	ltshhssscahDsasltls....s..ss.ph.htchhs....psPsWlstLhtlRstlVp.h.GLcs.....................shtsusp.........luhFslhspssp......ElllutcDpH.Lshclslthpstpt........lphoThV+h+Nhh.GRhYhhsltPhHt.lIV.shL	......................................hhhs.................................................................h..s..h..LWpsRuhhD+hl..Gtch............t+G.Rsptp..........hLpsGDs......................lDsW+Vl.hl-Pc.................p.L.L.hG.h..c.....ss...t......L.....G....R..L..s..h...s..lc..-cG..chcp..............lclp.....Aaa....HP.+Gh..GhhYWhhhhPsHh.aIF+GM..............	1	87	158	214
+10899	PF11067	DUF2868		Protein of unknown function (DUF2868)	Pollington J, Finn RD	anon	Pfam-B_002930 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as putative membrane proteins. However, this cannot be confirmed.	26.50	26.50	26.60	27.60	26.30	26.40	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.05	0.70	-5.29	35	236	2009-01-15 18:05:59	2008-07-31 16:14:17	3	3	228	0	62	233	20	301.60	30	66.01	CHANGED	phhhhht..p+htpsspss..hs.AL......hthhtptplt+WhlutlsHthWlshhhuuLhsLLlllsspcauFsWpTTL..LusssahpLspsLuh.ss...hlGhulPssphIpASchs.............sssssustttWusaLlusllsYGlLPRLlLhlhshhth+psttp..LslshPtYtpLppRhtssshphus.t-s-ssthspspsssshttts.....................................sslhsulElssp..............hs.shuttpsls-............sccthpplhtthsttsssplllsscsppsPDRGs.lshlspLsppssssphllLhsssu......................shssp+lppWpptlpphsls	...........................................................................tphh+stpss.phs.tL.......ht..hcp.hsRWhluthsHuLWLhsLlusLlslLhLlhsRpYsFsWEoTL..Lus..sshlplsphL.u.hlPu...hL..G..Fs...l..PDsphlhuoph...................ss.sstpuWushLlGsllsYGlLPRLLhhhhChhhh+puppt...LDLptPhYptLhcRhtsphtctss.p-ss..ssshspht.hsss................................................................................................................................................................................sthhlslEhc.p..............h.sthsptlhDts.....................hssRcpht..tL.ppLpph.P.....up..lll..us.csppsPDRGs.LthlscLuc..sAtust..lhhL.s.tu.....................ps..sp+ltpW+ptLpphth......................................................................................................................................................	0	17	34	54
+10900	PF11068	YlqD	DUF2869;	YlqD protein	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_002915 (release 23.0)	Family	The structure of a representative of this family has been solved (pdb:4dci) and found to form a tetrameric structure of prefoldin-like architecture with the beta-barrel core and helical coiled coil tentacles. This suggests that this family may act as molecular chaperones.	27.00	27.00	27.20	27.60	25.90	25.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.52	0.71	-4.11	29	228	2009-01-15 18:05:59	2008-07-31 16:23:28	3	3	221	8	66	190	120	129.00	34	95.09	CHANGED	lplhRslsVKslVT.phKc-htpplptplspl-pplpQL-hpsp+hlp-hppps.........pQltplppQhspc+schhEp+ppllpQlpQlppLplspEVtpGplEuhhclplGDslhppM.pspIll+DGllpEIR	....hplhpsVsVKtllT-p.Kpclhpphppphppl-p-hpQLchptp+h.pc..p...................pQ.pplppphspchschhEp+cpl..QhpQlchLpLGsElpptplEshhcVplGDshpcph.sspIll+DGllhEIR.............	0	20	49	60
+10901	PF11069	DUF2870		Protein of unknown function (DUF2870)	Pollington J, Finn RD	anon	Pfam-B_002904 (release 23.0)	Family	This is a eukaryotic family of proteins with unknown function.	21.50	21.50	21.50	21.80	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.13	0.72	-3.96	21	183	2009-01-15 18:05:59	2008-07-31 16:36:42	3	2	128	0	101	164	1	83.20	47	31.03	CHANGED	cApLWaAGKpL.tcscpLs-Y.lG+NEKTKllVKlpt+spGAPuREPhlsp-pQ+phMthha++QEEhKcLEps--csalsSpWusspuL+pphpGhts.l	................ApLWWAuKEL.tcsKpLsDY.lG.+NEKTKIIlKlpp+GpGsPuREPhlsp-pp+thMhaha++Q............EEhKcLtps-.-cshhsu.WusspsL+pphpGht...............................................	0	32	46	78
+10902	PF11070	DUF2871		Protein of unknown function (DUF2871)	Pollington J, Finn RD	anon	Pfam-B_002884 (release 23.0)	Family	This family of proteins has no known function.	26.10	26.10	26.50	26.70	25.30	26.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.59	0.71	-3.99	17	570	2009-01-15 18:05:59	2008-07-31 16:50:41	3	1	524	0	40	228	0	122.30	48	84.36	CHANGED	MKKlh.suhhYhIlGLluGlFYREaTKhpsFs..GpTpLsllHTHhLVLGhlhFLIhLhL-K.FtLops..phFshFFllYNlGLllTlshhhh+GlhpVhGhsh....ssuluGlAGlGHIlloluhlhFhllLp+ul	....................M++Lh.uhhhYhIIGLhSGhFY.REhTKshsas..G.sTpLslVHTHoLlLGhhhFL...IlLsL-.K.lFpLoph..hh.FshFFhlYNlGlllTluhhss+GhhQVs..Gts.h...........spuhuGhAGlGHshhhsuLlhhhhLL+pu................	0	19	28	37
+10903	PF11071	DUF2872		Protein of unknown function (DUF2872)	Pollington J, Finn RD	anon	Pfam-B_002883 (release 23.0)	Family	This bacterial family of proteins has no known function.	23.20	23.20	23.90	41.70	21.20	23.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.70	0.71	-4.31	31	147	2009-09-10 21:27:12	2008-07-31 16:58:52	3	1	144	0	38	146	453	138.40	54	92.64	CHANGED	YLSGEIHTDWR-cIhpGupt.sLslpFouPVTDHsuSDssG.sILGsEcspFW+D+KuAKlNuIRT+phI-cuDlVVVRFG-KYKQWNAAFDAGaAuALGKslIllHsc-htHPLKEVDAAAhAVscTP-QVVclLcYVhp	.YLSGEIHTDWR-cItcuuct.hsLslsFsuPsTcH-uSDssG.sILGtpsssaW+D+puuclNuIR...........T+phlpcADlVVVRFG-.KYKQWNAAFDAGYAuALGKPlIll+sc-lpHPLKEVcAuA.AsscTscQlVclLpYVh.p.........	1	18	31	35
+10904	PF11072	DUF2859		Protein of unknown function (DUF2859)	Gunasekaran P, Mistry J	anon	Pfam-B_001915 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	25.60	25.20	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.64	0.71	-4.73	34	268	2009-01-15 18:05:59	2008-07-31 17:10:28	3	1	208	0	65	232	4	133.20	41	84.96	CHANGED	ltDhG.GtsshPaapuls.pssp............s.stss.sssspushLPVpSscLo...PGsVptRslp.......hPGh...pPlFLlGDDshSppWLpp+tspLcphpAlGLVVNVsohtsLppL+plA.PGLslhPsoG-DLAcRL...sLcHYPVLITsTG.lp	..........................ltDhG.utss.Phhpsls.p.p..............s..ssst..stushLPVposcLo...PGpVt.tR.slp.......hPGh...tPlFllGDDshSppWLpp+tstL+phpAlGLVVNVpohptLptLpphu.sGl.LhPssuD-LApRL...tLpHYPVLITssul.......	1	8	30	52
+10905	PF11073	NSs		Rift valley fever virus non structural protein (NSs) like 	Gunasekaran P, Mistry J	anon	Pfam-B_001643 (release 23.0)	Family	This family contains several Phlebovirus non structural proteins which act as a major determinant of virulence by antagonising interferon beta gene expression [1].	25.00	25.00	25.80	25.50	22.00	21.20	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.44	0.70	-5.11	15	202	2009-01-15 18:05:59	2008-07-31 17:12:38	3	1	47	0	0	155	0	225.20	55	91.26	CHANGED	PsIspssuhschhsoVsYlsFsp.tspslSsapshEIPlcpaR.uhcpRspLScFhspuEhPtpWGsu...SpVpptssphFDstIpcLuchslcshpR.shPNlccALSWPLGaPohcFFphus.h-sappshppKsshuTpllRh.....Gs.upsLD-slVpsH++lLtEuppRGlsp-hhsGaDlhKEIAhlQhlRllsAlshDhss.....................................sssssslhshlhpp+tshpsp..thlGNppWhPl....s	.........................................VSVEYI+GDGPPRIPYSMVGPCCVFLMHHRPSHEVRLRFSDFYNVGEFPYRVGLGDFASNVAPPPAKPFQRLIDLIGHMTLSDFTR..FPNLKEAISWPLGEPSLAFFDLSS.TRVHRNDDIRRDQIATLAMRS.....CKITNDLEDSFVGLHRMIVTEAILRGIDLCLLPGFDLMYEVAHVQCVRLLQAA.+EDISN.....................................AVVPNSALIALMEcSLh..................h......................	0	0	0	0
+10906	PF11074	DUF2779		Domain of unknown function(DUF2779)	Gunasekaran P, Mistry J	anon	Pfam-B_001581 (release 23.0)	Domain	This domain is conserved in bacteria. The function is not known.	23.10	23.10	23.10	23.60	22.80	23.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.99	0.71	-4.10	49	211	2012-10-03 01:22:09	2008-07-31 17:15:01	3	3	194	0	74	206	203	136.70	28	22.99	CHANGED	halDFEThssAlPhacsspP.YpQlPFQaSlHl.ppss...tp...hpHh.paLs.t.s......hDP+pthlcpLhptlspp................................................................GsllsYNpu.FEpopLpE.huph.........................hs-htphlppIh..............pphlDLhchFppt..................aYcsphpGShS	...............hahDFEoh.p.ulPhacsspP.ap.QlsFQaSlcl.ppss...ts...h.pHh.talt.p.h......tDPRpt....hhppLhphlspp................................................................ushlsYNp.u.FE...ps..pLpc.lAph......................................................hschpptlppIh......................pphlDLhshFppt..................hhpsphpGshS........................	0	34	61	70
+10907	PF11075	DUF2780		Protein of unknown function VcgC/VcgE (DUF2780)	Gunasekaran P, Mistry J	anon	Pfam-B_001695 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.10	22.10	24.10	22.70	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.94	0.71	-4.19	32	234	2009-01-15 18:05:59	2008-07-31 17:15:52	3	1	220	0	62	185	18	154.60	35	91.16	CHANGED	llhhhslhossupA.h.hsshstt.......................tt.htttsspssssspsssLlsslhupLsloppQAtGGhGuLLulApssLuss-aopLuptlPGh-sLhuus...............s..su.suhLsph...LG................sslpuhsslpsAFptLGl...ssshlstFssllhsY.LsppG...sushLhpuLu	.......................................h.hhhhslsussuhA..as..tssts........................ss..ss.ss..tphsps.ttsssLlstlsoQLslospQAsGGsGuLLuhA....p....NpLsusphSpLsphIPGlssLtuss......................s..s................t....Lu................................sltshspVspAFssLGl...DsuMlppFsPllhpYLspQG....ASpsLLtSLu.............	0	13	26	45
+10908	PF11076	YbhQ		Putative inner membrane protein YbhQ	Mistry J, Coggill P	anon	PRODOM_PD083760	Family	This family is conserved in Proteobacteria. The function is not known but most members are annotated as being inner membrane protein YbhQ.	25.00	25.00	26.40	26.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.86	0.71	-4.55	3	433	2010-01-12 15:19:43	2008-08-01 11:37:37	3	1	432	0	22	82	1	131.30	87	98.04	CHANGED	MKWQQRVRVATGLSCWQIMLHLLVVALLVMGWMSGoLV+VGLGLCALYuVTVVhMLsFQRHHEuRWREVGDFLEELTTTWYFGAALIALWLLSRVLHNNLLLALAGLVILAGPAVVSLLAKDKKRastsFuSKHG	..MKWQQRVRVATGLSCWQIMLHLLVVALLVVGWMSKTLVHVGVGLCALYCVTVVMMLVFQRHPEQRWREVADVLEELTTTWYFGAALIVLWLLSRVLENNFLLAIAGLAILAGPAVVSLLAKDKKLHHLo..SKH.RV......	0	1	1	12
+10909	PF11077	DUF2616		Protein of unknown function (DUF2616)	Mistry J, Coggill P	anon	PRODOM_PD264505	Family	This cysteine-rich family is expressed by the double-stranded Nucleopolyhedrovirus, a member of the Baculoviridae family of dsDNA viruses.  The function is not known.	25.00	25.00	81.60	81.50	22.40	21.80	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.54	0.71	-4.77	14	34	2009-01-15 18:05:59	2008-08-01 11:38:50	3	1	33	0	0	29	0	179.10	33	94.21	CHANGED	ME...LIKPFlKYS+hYRsss.ssst..+phlacpWhp-hpppphth.......pshphts.th..........................CpFChs......sppps.......thhCppChFPL..s.......s.cpEhthYsLLSVCYaEssspss.sp.............................+sVWRp................Rl+hsW.p.cpp.+........lYplhhs..................p.ClQCpp......scpsssp.hhpFshchFCppChFPLFpI	...MELIKsFlKYS+tYRsss.sppt...+phlacpWsp-ltspphth.......pphhhpshtt..........................CpaChs........sspps.......thhCcpChFPl..h.p.....s.cpEhthasLLSlCYaEps..sst.....spst...........................+hVWtp......Rl+hsW.st-hstp........hYplhts...............p.ClQCppt.....sppsstp.hhpFshphFC.pChFPLFsI.....	0	0	0	0
+10910	PF11078	Optomotor-blind		Optomotor-blind protein N-terminal region	Mistry J, Coggill P	anon	Pfam-B_595 (release 23.0)	Family	This family is conserved in Drosophila spp. Optomotor-blind is one of the essential toolkit proteins for coordinating development in diverse animal taxa, and in Drosophila it plays a key role in establishing the abdominal pigmentation pattern, in development of the central nervous system and leg and wing imaginal disc-formation of Drosophila melanogaster. This is the N-terminal region of the protein and does not include the T-box-containing transcription factor that plays a part in DNA-binding.	21.00	21.00	21.80	81.10	19.60	20.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.11	0.72	-3.63	3	125	2009-01-15 18:05:59	2008-08-01 11:41:54	3	4	24	0	11	132	0	86.40	95	25.50	CHANGED	suPPsPPYFPAAALAALuGSsAGsHP.GLYPGsLlPKhPPH..huHPHP...HHPL.GuAYTTAEDVVLAAVAAHQHHPAM.RPLRALQ	....Q.QPPPPPY.FPAAALAALAGSPAG..PHH.PGLYSAAGGLRFPPH..PGHPHPHSHPHAHHPL..GSAYTTAEDVVLASAVAHQLHPAM.RPLRALQ	0	3	3	8
+10911	PF11079	YqhG		Bacterial protein YqhG of unknown function	Mistry J, Coggill P	anon	PRODOM_PD123329	Family	This family of putative proteins is conserved in the Bacillaceae family of the Firmicutes. The function is not known.	25.00	25.00	41.30	29.50	21.40	22.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.56	0.70	-5.57	11	186	2009-01-15 18:05:59	2008-08-01 13:12:26	3	2	165	0	35	146	0	223.40	52	94.96	CHANGED	MpQp-IHpFLpRaFpANsCsIlEcSPuahTVQLTlEMDKcLMNRPFYWHYLEKTGGlPNPMpLTLITcppcss-slcGEhIHFGSPRLaQIFpus+chGualRLYEphssssstpsPLcPWLGhNlKlSYQCDRKKDhllSlGLpLIsGpllEsFa-+LpphsLoscIPDYCFTlSPlIKPcSGlpRlcphlcshhcs-sc-WAcpAhcRWpcDLcLL-pFYEcsEEKPEsYclEKpALcc.YEP+IplsllNGGLFYLp	.................M..tpl.pah.pahts.ts.hhptt.thhpVQLoh-MDK.LMNRPFYWHYlEKTGGsPNPM+LTLITssEs.tps.-....GEhIHaGSPRLHQIFposKchGuaIRLY...Ecl.....c.......ps...u........us...c...sPLc..PWLGlNlKlSYQCDRKKDhLhSlGlHLISGThhtsFH-pLpplcLTP+IPDaCFTlSPlIKPpSGlpRlEshLcshlup-DHsWAcEA+hRWpcDLsLLs+FYE.....-.........s.........-Eh.....P.........Es....YclEKpA.Lpc...QYEP+IslpIINGGLFYl.p.......................................	0	10	23	25
+10912	PF11080	DUF2622		Protein of unknown function (DUF2622)	Mistry J, Coggill P	anon	PRODOM_PD066031	Family	This family is conserved in the Enterobacteriaceae family. Several members are named as YdiZ, a putative cytoplasmic protein. The function is not known.	20.80	20.80	21.10	20.80	19.70	19.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.00	0.72	-4.13	7	726	2009-01-15 18:05:59	2008-08-01 13:13:26	3	1	473	0	30	125	0	88.60	52	98.26	CHANGED	Musu-lTRYVlTVpaHE-oLTEINELsNHLTRsGFlLThsD--GslHELGTNTFGLlSu.St-ElptLsuGLupuALsKcs-IsVsTaE-WtKs.p	......ups-lspYVlohhhpEssLTElNELsNhLTRsGFhLThsD--Gs.HELGTNTFGllSop.ut-EI+-LlsuLspsAss+Ds-loIsTa--a.pt..p..................	0	2	3	17
+10913	PF11081	DUF2890		Protein of unknown function (DUF2890)	Mistry J, Coggill P	anon	Pfam-B_629 (release 23.0)	Family	This family is conserved in dsDNA adenoviruses of vertebrates. The function is not known.	23.30	23.30	23.60	24.10	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.72	0.71	-4.23	18	154	2009-01-15 18:05:59	2008-08-01 13:32:05	3	4	79	0	1	180	0	167.20	35	88.93	CHANGED	MsP+tps.KpLtsp.sPsc.........D.EEpWD..SQA.......tEEthE-W............DSL-E-.pEtE.EVEEtsssp.....phssoSsu.utSpsstSsPspsst...h+sp...pRWDpTuphssPossusss...................................................thstpc.suhRph+NpIhssL....QpSpGp.............tShTRp.hLYH+u.s..p+sLc.hctLaspYCuhs	....................................................................................................hp.s...p.............-.EEpW-..SQA.......pE-phE-.............tS.t--tE.E.hE..El-Etpssp..............ss..ss...t..s..sssspssh.osPstsst.......+ss...pRWD...pstt..ssst...t..ssttt...........................................................thp.tpshpShRth+stIhssL.....QpstGp................hShTRp.hLaH+u.s..ppsLc.hctLas.aht....................................................................	0	0	1	1
+10914	PF11082	DUF2880		Protein of unknown function (DUF2880)	Pollington J, Finn RD	anon	Pfam-B_001492 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.00	93.20	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.71	0.72	-4.09	3	5	2009-01-15 18:05:59	2008-08-01 13:35:43	3	1	5	0	5	5	0	78.80	60	65.78	CHANGED	lMAAulhhASuAsAAsslEhP+PRGKDEAPEAPVACMKAVKAALPNPDpFKWVuGTsRKVAEDAYSVVADVEYLupDGA	...lMALSlhsASuAsAAussEAP+PRGKDEAPEAPVACMKAVKAALPNPASFKWVGGTsRKVAEDAYSVVADVEYLAQDGA	0	0	1	3
+10915	PF11083	Streptin-Immun		Lantibiotic streptin immunity protein	Coggill P	anon	Pfam-B_43518 (release 22.0)	Domain	Streptococcal species produce a lantibiotic, streptin, in a similar manner to the production of nisin and subtilin by other lactic acid bacteria, in order to compete against competing bacteria within the environment. The immunity protein protects the bacterium from destruction by its own lantibiotic. In general, there is little homology between the immunity proteins of different genera of bacteria.	20.70	20.70	20.90	23.50	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.12	0.72	-4.01	12	173	2009-01-15 18:05:59	2008-08-01 13:38:42	3	2	152	0	7	87	3	96.80	46	22.38	CHANGED	IAplDl+LsphpEKIATLNKMAEVLlNLpSc-.po++LA+Y-FSKLNLTEoloLEpVpcEIphLQppLshhlDcYEphlR+L-pFVclLN..hsctht.ca	.............IAElDhcLppsQEKIATLNKMAEVLINLKS-sppo+KLA+Y-FuKhNhTESIpL-plscEIhcLQpELup.lscYEclsR+L-pFlKllN..hsK...................	1	1	3	4
+10916	PF11084	DUF2621		Protein of unknown function (DUF2621)	Mistrey J, Coggill P	anon	PRODOM_PD086666	Family	This family is conserved in the Bacillaceae family.  Several members are named as YneK. The function is not known.	25.00	25.00	25.50	25.50	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.83	0.71	-4.50	12	164	2009-01-15 18:05:59	2008-08-01 13:46:17	3	1	163	0	32	112	0	136.90	71	96.97	CHANGED	M....LpG..WFhhFILhWsllLlsLhuIGGFFMFRKFLKRLPKEDGKS.LDWp-aYI-pT+HLWs-EpKpLLpELVpPVPELFRDVAKpKIAGKIGELALcEcAspIsp-LlIRGYIlATPKRDHKFLhK+LpE+pIDhuPYEpLh	.......LpGWF.WFIlhWsVlLlGLMSIGGYFMFRKFLKRLPKEDGhShLDWpEaYIsKTRHLWsDEpKQLLEELVSPVPELFRDVAKuKIAGKIGELALpEpAopITpDLII+GYIlATPKRDHKFLlKKLpEKcIDaosYpsLL........	0	11	23	26
+10917	PF11085	YqhR		Conserved membrane protein YqhR	Mistry J, Coggill P	anon	PRODOM_PD101610	Family	This family is conserved in the Bacillaceae family of the Firmicutes. The function is not known.	26.00	26.00	38.90	37.50	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.25	0.71	-4.73	12	156	2009-01-15 18:05:59	2008-08-01 13:48:14	3	1	155	\N	28	109	0	166.00	51	98.23	CHANGED	M......sppppphcpppppp.hohhs+slhhGFsGGVhWShluYlsahFsFoEluP.NhlLpPaslG-WKcshlGshluIlhIGllSIusAFLYashL+KlcuhWsGllYGlhLWhlVFalhNPlFPsl+slp-LshsTllTTlClYILYGlFlGYSISaEhNEhp..ppp.t....tppp	.......................pphts.....................pphl.pIGhFGGlFWGuIhYhhalFsFTEsuP.NalLhPFAhGuWK-GshGNllGIVshGLLSIllAFLYpAhLtKFcGlhPGllYGLhWWuLLFauhG.lhPslKosh+Ls+-TIVTTICIFILYGVFIuYSlSatsNsp+tcpEt.t+s.....c..........	0	6	18	20
+10918	PF11086	DUF2878		Protein of unknown function (DUF2878)	Pollington J, Finn RD	anon	Pfam-B_001539 (release 23.0)	Family	This bacterial family of proteins has no known function. Some members annotate the proteins as the permease component of a Mn2+/Zn2+ transport system however this cannot be confirmed.	20.90	20.90	23.00	23.00	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.18	0.71	-4.22	59	319	2009-01-15 18:05:59	2008-08-01 13:54:18	3	1	313	0	84	276	229	151.30	30	86.58	CHANGED	hthllNhlhFQhsWhhsVlhs.sphhhhhhhh.....lhhHhhh......s..phts-hphllhlsslGhhlDulhhthGlhpF.............ssshhPl..WLhhLWhhFuhslspuL.saltphsh.lhsllGuluGshSY.hAGt+luA.VphshshhhohhlLulhWullhPll	....h.hhlhsslhFplhWhhuVlut..p...p.hhhlhsll.........llhphhh......s..pttsphphhlhhsllGlhlDohhhhhGlhsF.............ssshhPl....WLlsLWhsFuhhhs+.L.shlpphsh.lhslhGulhGslSY.asGh+.huA..VphshsshhshlsLsltWsslhsl...........	0	18	34	64
+10919	PF11087	DUF2881		Protein of unknown function (DUF2881)	Pollington J, Finn RD	anon	PRODOM	Family	This viral family of proteins has no known function. Some members are annotated as p34 however this cannot be confirmed.	25.00	25.00	115.60	115.30	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.65	0.72	-4.49	2	14	2009-01-15 18:05:59	2008-08-01 14:59:55	3	1	6	0	0	2	0	54.00	75	88.52	CHANGED	Ms-FstsllTllTAIIGVAIlAVlVSppSNTAGVIpuuouGFSshLtoALuPlh	Ms-FstsllTllTAIIGVAIlAVlVSppSNTAGVIpuuouGFSshLtoALuPlh	0	0	0	0
+10920	PF11088	RL11D		Glycoprotein encoding membrane proteins RL5A and RL6	Pollington J, Finn RD	anon	PRODOM	Family	RL5A and RL6 are part of the RL11 family which are predicted to encode membrane glycoproteins. Two adjacent open reading frames potentially encode a domain that is the hallmark of proteins encoded by the RL11 family.	25.00	25.00	25.20	33.50	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.38	0.72	-4.18	4	33	2009-01-15 18:05:59	2008-08-01 15:20:20	3	1	5	0	0	28	0	87.50	44	92.09	CHANGED	hpKLpsopGcNlTIscccD.hoTcWcph..ssGst.LCNVTupGssllNs..TlCVSSCoHTSLsLCNhTpts-ulaslG+hhs...DE.sGELWhloVS	.................hp+LpsopGcNlTlscc+c.hootWcpa......D.sG..st.LCNVTupsssslNo..ohCVosCuHooLsLCNhTpts-uhaslu+hhs...DE.sG-lWhlpVp............	0	0	0	0
+10921	PF11089	SyrA		Exopolysaccharide production repressor	Pollington J, Finn RD	anon	PRODOM	Family	SyrA is a small protein located in the cytoplasmic membrane that lacks an apparent DNA binding domain. SyrA mediates the transcriptional up-regulation of exo genes involved in the biosynthesis of the symbiotic exopolysaccharide succinoglycan. It does this through a mechanism which requires a two component system [1].	25.00	25.00	25.50	25.50	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.81	0.72	-4.15	6	37	2009-01-15 18:05:59	2008-08-01 16:07:23	3	1	26	0	17	35	0	37.80	45	41.27	CHANGED	AlAsYFsotShhsAhVsTLsCulLLQluYFluVLFLla	.AlAoYahstShhsshlpTLhCuVLlQlGYFhuVLhLVh....	0	1	6	9
+10922	PF11090	DUF2833		Protein of unknown function (DUF2833)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins with unknown function are found in the bacteriophage T7. Some of the members of this family are annotated as gene 13 protein.	25.00	25.00	26.70	26.30	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.78	0.72	-3.82	5	41	2009-09-11 15:53:06	2008-08-01 16:15:47	3	1	38	0	0	34	35	84.80	42	57.97	CHANGED	ssVshslsGhVLAIGGNpGDpVWFVTSchVa+LocKpKREFRKLIhEYRDtML-Q.YsoIWNYVWVGNKSHIRFLKoIGAVFHcEaT	................lsh.hhGhslAIGGss....u.spsWFlTSspV...h....phstpt+hcFR+hlhcahDphLcp..Ysp.LWNaVWsGNpuHIRFLKolGAh..Fcp-........	0	0	0	0
+10923	PF11091	T4_tail_cap		Tail-tube assembly protein	Pollington J, Finn RD	anon	PRODOM	Family	This tail tube protein is also referred to as Gp48. It is required for the assembly and length regulation of the tail tube of bacteriophage T4 [1].	20.20	20.20	20.30	20.50	19.80	19.90	hmmbuild  -o /dev/null HMM SEED	348	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.01	0.70	-5.74	8	48	2009-01-15 18:05:59	2008-08-01 16:25:33	3	1	47	0	0	41	153	313.60	32	90.19	CHANGED	+VK-.Is.csschhtuh.uupssAGtsocsc..ssophhsAQFPspRAuGNDsst.a.lsDLYKNGLLFTAYshouRsos....sLRshRp.....ssssIhSptsusVpsphstho...........tshhsppAlANILLPRSpSDVDssSH+FND.....ls-SLls+GGuouoGsLSs.......hASTAlaGuLESITpGhhAD.........suEQIYssoRoMYuGu-sRTKsasWpLTPRShpDLhpIlpIYchFshaSYGpoutSphAtElKuplDshY+sThhc.hss.sshpNpT........LhEtIT.uFLoNVhVVSNPslWhI+NFGsooua.....-shp-sFGPsQIpSlRFDKTPDGpFNGLAluPNLPSoFsLElTFREIIsLsRuo	........................................................................................h...hhs.htt..stt.suG..o.tt....pthhsAQaPstRsuusDss..h.hssLYpNGLLFoAashsup.os....phRs.Rp.....ttp..phhp.tttssl..th.t.s..............hspps.l...ssILhPRupoDs-ssSH+FND.....Vt-SLls+Guuouo.GhLSN.................hAST...AlaGulE.......Slo.......p.GhhAD........................pGEQlhssu+uMYsGs-sRTKsFoachoPRshpDLhpIlpIYchFp.....hhSYGpsGpSp..hAt-..l+s.lDshY+sThhp.h.....s.s.tsps...............hhEthT.uhloNV..hVlosP...slW...hl+sFu...pssph.........-shp-hF...GPstIpSIRhsKoP-GpFsuLA...huPNhPS...o...hsLElThpEllsLsRu.......................................	1	0	0	0
+10924	PF11092	Alveol-reg_P311		Neuronal protein 3.1 (p311)	Pollington J, Finn RD	anon	PRODOM	Family	P311 has several PEST-like motifs and is found in neuron and muscle cells. P311 could have some function in myo-fibroblast transformation and prevention of fibrosis [1]. It has also been identified as a potential regulator of alveolar generation [2].	25.00	25.00	56.20	56.10	20.10	16.20	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.27	0.72	-4.01	4	38	2009-01-15 18:05:59	2008-08-01 16:31:11	3	1	24	0	16	33	0	62.60	68	93.40	CHANGED	MVYYPELhVWVSQEPFPsK-MEGtLsKGRLPVPKEVNRKKpsEstAASLsPlGusEh+SPtIuYLHsF	.MVYYPELhVWVSQEPFPNK-MEGRLPKGRLPVPKEVNRKKssETsAASLTPl.GSs..EL+SPpISYLH.F......	0	1	1	3
+10925	PF11093	Mitochondr_Som1		Mitochondrial export protein Som1	Pollington J, Finn RD	anon	PRODOM	Family	Som1 is a component of the mitochondrial protein export system. The various Som1 proteins exhibit a highly conserved region and a pattern of cysteine residues [1]. Stabilisation of Som1 occurs through an interaction between Som1 and Imp1, a peptidase required for proteolytic processing of certain proteins during their transport across the mitochondrial membrane [2]. This suggests that Som1 represents a third subunit of the Imp1 peptidase complex [2]	21.40	21.40	22.70	22.10	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.04	0.72	-4.18	10	77	2009-01-15 18:05:59	2008-08-01 16:33:09	3	1	76	0	57	72	0	83.00	31	76.66	CHANGED	MAPPTPVhotcElppphssthpsstch......cCpLKSLTQaECsF+so.tts....sEhICLPFKRLFpcClhP.............c+hlNIElTDppTN	.............................MuPP...sslhstppl.tphtp..pt.tph..............pCp.LhplsQapCsh..css.......t.......stll.ChPhpRLFc+C...........................ts.thslEsTshpt..................	0	9	30	48
+10926	PF11094	UL11		Membrane-associated tegument protein	Pollington J, Finn RD	anon	PRODOM	Family	The UL11 gene product of herpes simplex virus is a membrane-associated tegument protein that is incorporated into the HSV virion and functions in viral envelopment [1]. UL11 is acylated which is crucial for lipid raft association [1].	20.30	20.30	20.50	43.60	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.80	0.72	-4.14	11	49	2009-01-15 18:05:59	2008-08-01 16:39:40	3	1	32	0	0	40	0	39.80	52	42.96	CHANGED	MGQusStutss....CCR..pNhLlTcsGEsluLsA-sF-sF-L....-	MG.uhSsupss....CCR..pNhLlTcsGEVVoLsAcsF-shDlE...........	0	0	0	0
+10927	PF11095	Gemin7		Gem-associated protein 7 (Gemin7)	Pollington J, Finn RD	anon	PRODOM	Family	Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE [1].	21.50	21.50	23.30	30.60	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.50	0.72	-4.24	7	68	2009-01-15 18:05:59	2008-08-01 16:52:05	3	2	59	2	45	74	0	78.10	46	57.14	CHANGED	popEQ+tRusLRERaL+SL.sMss+sssFThHEtsp..VsApFtAoDlsltNFhVSpLpTPIGlpsEAlLRsoDllSaTFcs	............pEQcARuhLRERaLRo...LluMs...G+p.VsFs..LHEslc..VsA.cFsAoDlDltNFhVSpLpTPlGV.Q.sEALLRssDIIuaoFc......	0	15	19	34
+10929	PF11097	DUF2883		Protein of unknown function (DUF2883)	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins have no known function but appear to be restricted to phage.	25.00	25.00	30.40	30.30	19.00	16.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.67	0.72	-3.86	3	35	2009-09-11 15:42:54	2008-08-01 17:04:17	3	1	34	0	0	22	0	73.20	86	100.00	CHANGED	MLNNNVVYLGYPGLPPNKLEGLMLELRTVARCSGLEFRFQDTPRRGKNYTQMHILKQRSKTGAFVMHYKPRKEKF	MLNNNVVYLGYPGLPPNKLEGLMLELRTVGPSSGLEFRFQDTPpRGKNYTQMHILKQRFKTRAFVMHYKPRKEKF	0	0	0	0
+10930	PF11098	Chlorosome_CsmC		Chlorosome envelope protein C	Pollington J, Finn RD	anon	PRODOM	Family	Chlorosomes are light-harvesting antennae found in green bacteria. CsmC is one of the proteins that exists in the chlorosome envelope. CsmC has been shown to exist as a homomultimer with CsmD in the chlorosome envelope [1]. CsmC is thought to be important in chlorosome elongation and shape [1].	26.30	26.30	26.70	126.80	26.10	26.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.47	0.71	-4.47	5	13	2009-01-15 18:05:59	2008-08-04 09:12:01	3	1	13	0	11	12	0	138.80	73	99.18	CHANGED	MSESYQKLRKDFKDLEFTDRLTFLAEGsLLTGQSAVVGGLELAGSVVETVAGTVGSLlDATGIG+LLGsTGGVVGETIDRVAITVKDVSRSAGELYSDAVKNVENVTDNAA+AIGDAGVSASEAVKNlsGSFQKosGKK	MSESYQKLRKDFKEL-FTDRLTFLAESlLLTGQSAVVGGLELAGSVVETVuGTVGSLlDAoGIGslLGsTGGVVGETIDRVAITVKDVSRSAG-LYsDAV+NVENVTsNAAKAlGDAGVSASEAVKNlAGSFQKssuKK..	0	1	2	8
+10931	PF11099	M11L		Apoptosis regulator M11L like	Pollington J, Finn RD	anon	PRODOM	Family	Apoptosis regulators function to modulate the apoptotic cascades and thereby favour productive viral replication. M11L inhibits mitochondrial-dependant apoptosis by mimicking and competing with host proteins for the binding and blocking of Bak and Bax, two executioner proteins [1].	25.30	25.30	25.40	42.40	24.70	25.20	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.96	0.71	-4.51	9	129	2009-01-15 18:05:59	2008-08-04 13:01:09	3	1	37	6	0	96	0	160.50	52	77.66	CHANGED	+sllh........................hYlsctslsc....LsshEpslLshIppsC-hIppsYppshs.lss.hlchsshSh.sIpcIKsplhpsLhsDspPSVKLAolSLlShIhc+hh..scslhh.shlhs-IhstIotptcplIsFIpcppc.sss...h...cphlplhshhshh.hlsYhhlKahh	.p..hVY........................YYhsKpRLD-hYRpLsopoRSalDlIshhCDKlNNDYs+DhNlMYD...hASscSa.slhDIsNEV.soILhsspulGVRLATISFIopluKRshNslcTI+MhoLLScsIsD......-pFlDYIschs..ssss..s.hpT.Rchl+lhGlssIh.FsTYtsLKYh.......................	0	0	0	0
+10932	PF11100	TrbE		Conjugal transfer protein TrbE 	Pollington J, Finn RD	anon	PRODOM	Family	TrbE is essential for conjugation and phage adsorption. It contains four common motifs and one conserved domain [1].	25.00	25.00	74.40	74.20	22.10	19.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.32	0.72	-4.12	4	124	2009-01-15 18:05:59	2008-08-04 13:04:03	3	2	103	0	2	68	0	65.30	77	78.99	CHANGED	+llsFLlRLolTlIVISPslYWSWDsVKsTTA-DhlhAsllIhhsGlhhhlLYhFhslLTKlhptD	..RFIDFLIRLLITAIVISPVIIWSWDTVKETTADshLAAAFVILYSGVL.LFILYFCFSALTDLQKs....	0	0	0	1
+10933	PF11101	DUF2884		Protein of unknown function (DUF2884)	Pollington J, Finn RD	anon	Pfam-B_001481 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.	30.60	30.60	31.30	32.70	29.20	29.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.31	0.70	-4.98	39	793	2009-01-15 18:05:59	2008-08-04 13:22:51	3	1	717	0	94	390	15	209.20	48	88.49	CHANGED	CsVslpt-lhlsspplplhpsss.......pphhIspsspLalsGcplsLsscQpptlppYppslpptlPplhplAp-ulplApsAlsplhsshhu..spshsplpphhsplptplpphhhppssphhhsspthst....hpp.appchEpthcphlppShGolhhslusph.....tpGs....phsshtpphssltppl-pphcppupsl-t+AcplCsplpsLsp.EppLpttlPpLtshplhp	........CSVoP+DDVIlSPQoVQV+GcNG........NLVIo.PDGNVhhNGKphoLsAAQRcQA+DYQucLRSsLPWID-GA+sRVEKARlALDKlIspphG...psSphRuRLTcL-AQLKpQMNRIIEpRoDGLTFHacAIDQ.............VcA....-GpQLVsQuMGGILQDSlNEMGsK..tshcuGG......NPLQ.slhGSLGGLQsu.IQsEWKpQE+DFQQFG+-VCuRVsoLE-sRKAL..............sst............	0	12	31	60
+10934	PF11102	Cap_synth_GfcB	DUF2886; Cap_synth_GfcC;	Group 4 capsule polysaccharide formation lipoprotein gfcB	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_1366 (release 23.0)	Family	This family includes lipoprotein GfcB (YmcC), involved in group 4 capsule polysaccharide formation [1].	20.20	20.20	20.20	21.10	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.13	0.71	-4.76	39	859	2009-09-11 10:59:46	2008-08-04 13:41:14	3	1	602	2	69	362	161	193.80	52	91.11	CHANGED	LsuCopp.........hpshssolphuh.............hsstssslospplps.sshsshhhplsstspshhlLshs-p...............hpWhosDpthlshcsGhllpTpuLss..sLhus..............pssshhthhpt.....ssstshphphphsst........chshh.hpsphph.upcsltlstt.shpshchpEpsphs........stp....apNpYWl-sssGp....llpScQhluPshshlphphL	...............................LpuCoto.............ppplssolhsSL................FGssslploDp.p.IQs.hPYAS.Yhp.LNsGsplFVVLAasEs...................sQpKWlo.QDpAhLVTppGRLVKTl.hhss..NLlEVs...........N.usDPLhpshpI.......hDGusWTRshsWoEt.......pph..RhATspSsFp.asGs-Tlpluuc...cshspVhsEEVoos............ptpWpNpYWlD.S.pGQ....lRQScQhLGAshhPVchTh.....................................................................................	0	8	27	49
+10935	PF11103	DUF2887		Protein of unknown function (DUF2887)	Pollington J, Finn RD, Bateman A	anon	Pfam-B_1330 (release 23.0)	Domain	This bacterial family of proteins has no known function. These proteins may be distantly related to the PD(D/E)XK superfamily.	22.40	22.40	22.70	22.60	22.10	22.30	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.13	0.71	-4.71	29	232	2012-10-11 20:44:46	2008-08-04 14:02:13	3	5	44	0	85	297	45	160.80	36	68.55	CHANGED	TDslFY+LFpp.PshlFELls.pssspAcsYcFsSVElKppsFRlDGVFlPhtst.stPlaFsEVQFQpDpphYpRlFAElaLYltppp.p.scWpuVlI....YssRsl-.sshhsacplLsuspVpRlYLsELsshpp.slsluLltLh.lhspppssppA+hLlppsp.....pphhsttppppll-lIpTIllYKFsplS+cElcAML	.........................TDplFYplFtp.PphhF-L..ls..sstpsp.YpFsShplKphtFRlDGlFhP.tp...s.PlahsEsQhQ.DtthY.RhFsElalYltp.p...psWpslll....ass+ph-......t.......apthlp....tp....l......p.RlYL....s....-.....Ltp.....t.s.lslu.h.l.pLl..h.sptps.ppuptLlppsp.....pp........ppllpLIEoIllYKhPphoccElptMh......................................	0	5	66	85
+10936	PF11104	PilM_2	Competence_A;	Type IV pilus assembly protein PilM;	Pollington J, Finn RD, Eberhardt R	anon	PRODOM	Family	The type IV pilus assembly protein PilM is required for competency and pilus biogenesis [1-2]. It binds to PilN and ATP [3].	66.50	66.50	66.50	67.00	66.40	65.90	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.87	0.70	-5.56	37	952	2012-10-02 23:34:14	2008-08-04 14:34:40	3	4	881	1	318	846	348	315.90	25	86.32	CHANGED	GlDIoSouVKllELoc.ps..spa+lEsaAhtslPcsuls-tsIt-h-uVucsl+plhcctssps+psAhAVsuSuVITKhI.hsusLs-pELEsQl.chEAspaIPasL-EVslDFpllG.s...tsssscVcV..LLuAsR+EsV-sRlssl.....-tAGLpscVlDVEuaAlpR.Ahphlhpp........Lsssspsp.....sVA.............llDIGAshTslsVlpsGphlYsR-QsFGGpQLTppIt+pYGhohEEApttKppGsLPc.............sYp.-lLpPFhpslsQplsRuLQFFhoooths.pVDtllLuGGsAsl.GLschlppclGhsThlsNPFtsMplusc.lptptLpp-usuhhlAsGLALRuF	.............................................GlDIuspulKhlpLp......t....pt.....sp....hplppauhhslPts....sl.s....-s.p.....lh-h.pt...l........sptlpchhpph...s.h.p..s+.pss.h..ul..ss.s.s.V.Is+.hlp.hss.sh....s-.c-.lEt.t.l.phEs..sphl..P..a..s.l-E..lsl.Daph.ls.p..................s..ss..s...p..h.....pV..LlsAs++-.l-shhssh.....ptA..GLpshll..D.V..csaAlt.p..sh.p.....h....h..tp.......................hs.t.t.....t..tt.....hls...................llDlGu.shoslslhpsup.hl.a.pR....ph..s.hG.u.ppls.ptlt......pt..h.....s..l.s.h...ppA...........t.......h.h...t.....p.....t....s....l.....sp.....................................s..h..........p....s....lp.....h...hp.p...lspplpRsl...paa..h...s...s...s...t..tp...p................lsp..lhLsG.G.sutl...GLsphl.ppp.hshss.hhs.Ph..t....h.th.s.p...p..p.....ht.ptst..hhhuhGLAhRt.....................................................................................................	0	121	226	283
+10937	PF11105	CCAP		Arthropod cardioacceleratory peptide 2a	Pollington J, Finn RD	anon	PRODOM	Family	CCAP exerts a reversible and dose-dependant cardio-stimulatory effect on the semi-isolated heart of experimental beetles. CCAP also increases free hemolymph sugar concentration in young larvae and adults of the meal-worm beetle [1].	20.20	20.20	21.20	35.90	19.70	19.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.81	0.71	-4.43	4	47	2009-01-15 18:05:59	2008-08-04 14:41:47	3	2	33	2	22	50	0	102.10	32	82.57	CHANGED	hpsohshLLhLlshlhC....l-CuhssppPRsacthssEs...ss......pKRPFCNAFTGCG+KRSpsssss.......PsshhpRp.........-.lppc..sNE...EuLusLlDLNoEPAVE-L.RQIMSEAKLWEAIQEAs+EIahQKptpK..p	..........................................h.hhhhhh.....h.ss.s...h..p..p..p...tp..............pKRPFCNAFTGCG+KRop.......................................p....tshtsh..hps-.t.-pl.+QhhopsKlaEsIpEAphEl..pppt...................................................	0	10	12	19
+10938	PF11106	YjbE		Exopolysaccharide production protein YjbE	Pollington J, Finn RD	anon	PRODOM	Family	YjbE is part of a four gene operon which is involved in exopolysaccharide production. The expression of YjbE is higher than the rest of the operon yjbEFGH. It appears to be restricted to Enterobacteriaceae [1].	25.00	25.00	26.40	26.00	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-9.89	0.72	-4.01	2	379	2009-01-15 18:05:59	2008-08-04 14:48:45	3	1	368	0	17	71	1	79.80	92	99.09	CHANGED	MKKlL.GlFAIsALuAsSspAAPVpVGEAAGSAATSVSsGSSSATusSTVuSsVGVALAATGGGDGSNTGTTTTTTTSTt	......................MKKVL.YGIFAISALAATS.AWA.....APVQVGE...AAGSAATSVSAGSSSATSVSTVSSAVGVALAAT.G..GG....DGSNTGTTTTTTTSTQ......	0	1	1	13
+10939	PF11107	FANCF		Fanconi anemia group F protein (FANCF)	Pollington J, Finn RD	anon	PRODOM	Family	FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway [1].	21.10	21.10	22.50	22.50	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-12.16	0.70	-5.19	7	69	2009-01-15 18:05:59	2008-08-04 14:58:34	3	3	50	1	39	61	0	285.20	27	85.35	CHANGED	M-slLcplctFl-lLslu....postVtsWD.tsl+RAhpWAtYhcpla++hpspsslcpuLppcLpst.pp.uss..hPs.hp.hsFpsLupscpllhhpLLpN.sltstph.hll.pL.......s.pt-t-sLpsshsphssp+ushphL......................phsutppssphppsohhpsp.................uclLhchLpchhp..sps.cpstphLspLh..cth.pssahpllAssLLpssss.pp.p.............spchLlpWLht...psshhssFCp.l.utLLsploh+hsphpshYhshLpphupph..........................ph-l.cuhhlusEsp.hsa-tLhp+hpuL..hpus.sl..pptshssLcshptQD....Gs.pl.GhSlWsDlhLtLt	.................................MEtlLpplctFs-lLslu....postVpsW-stslcRAlpWApYhcclac+htpp.stlR.pulpccL..cst.tp..sss.....hs...t.h......shpsLupsc.ll.hpLLpN.sL.....tstththll..ph..........s.p.p.ptl..tphsphhppc.s.phL.....................................ps.htsp.................uplLhppLpphhp.....hps.p.stphL..splh...pth.ps..s..hhp.hAssLL.........s.....p.........................pp.llpWLht.................thhtshCh...shlLs.hs.+hstht.hhhshhpphhphh...........................h-l..cthhlss...tsp....appL.hp+h.sL..hpus.sl..ppts.ptLpthptpD.......ps......pDhh.th...............................................................................................................................	0	7	13	24
+10940	PF11108	Phage_glycop_gL		Viral glycoprotein L	Pollington J, Finn RD	anon	PRODOM	Family	GL forms a complex with gH, a glycoprotein known to be essential for entry of HSV-1 into cells and virus-induced cell fusion [1]. It is a hetero-oligomer of gH and gL which is incorporated into virions and transported to the cell surface which acts during entry of virus into cells [1]	25.00	25.00	42.00	41.60	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.70	0.72	-4.09	9	36	2009-01-15 18:05:59	2008-08-04 15:34:02	3	1	25	16	0	30	0	109.10	32	71.22	CHANGED	PCCpl.sLstsp.lPulasIssIalssspo.CsGhslApL...+ptsspsTh...phCuNGFNlhSFhlulLp+ls.ss.tEphcLLstLpp.hsuF.lsshpsssssu.thp....uhpG	.PCC+I..psh..sspp.hP..thasIssIaLssspp.CsGhslApL...+ppssphsh...phCsNGFsLhuFhlullp+h.s.ss.t--lcLLstLpp.hssF.hpsFpssssNuSth.....hss.....	0	0	0	0
+10941	PF11109	RFamide_26RFa		Orexigenic neuropeptide Qrfp/P518 	Pollington J, Finn RD	anon	PRODOM	Family	Qrfp/P518 has a direct role in maintaining bone mineral density [1]. Qrfp has also found to be important in energy homeostasis by regulating appetite and energy expenditure in mice [2]. The c-terminal 28 residues are the functional 26RFa [3].	25.00	25.00	39.20	39.20	23.70	21.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.78	0.71	-4.26	3	30	2009-01-15 18:05:59	2008-08-04 15:46:31	3	1	27	0	16	31	0	123.40	60	97.11	CHANGED	hRPYsLlYhLFLPLGACFPLLDRREPTDAlGGlGAcMsWADLAcG.RPas.WGSPsWlRAPQPQALLVlARELQASGREHAGhpFRLGRQD-GSEATGFLPA-uEKsSGPLGTLAEELNGYSRKKGGFSFRFGR	...........tsasLshL.LhLPLGsCFPLLDR+pPsDshGshGu.thsWAcLAtG.+..P.as.W..Gus.pWhRAspPpALLVlA+tLQsSGRE+AGhpFRFGRQD-GSEAsGFLPAs.uEKsSG.PLGsLAEELNGYSRKKGGFSFRFGR	0	1	1	4
+10942	PF11110	Phage_hub_GP28		Baseplate hub distal subunit	Pollington J, Finn RD	anon	PRODOM	Family	These baseplate proteins are also referred to as Gp28. Gp28 is the structural component of the central part of the bacteriophage T4 baseplate, which possesses a hydrophobic region and is membrane bound [1]. Gp28 forms a complex with gp27 which is another structural component of the baseplate [1].	25.00	25.00	36.10	35.50	23.00	17.40	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.90	0.71	-4.53	6	31	2009-01-15 18:05:59	2008-08-04 15:49:07	3	1	30	0	0	24	0	148.30	46	84.65	CHANGED	IPKLGlKHh+LLKDh+GsD-sh+lLlDSIpPGLoAAEsDhVhLHLLtFNsKlpohpphDGashclsDlYlCp+hEFpapGpTFaFKsPthh.-pFlohsDhLo+...phsD-ps..-hsFh-hPAFVlcWA--IhoTIAlssPsGsIpGhusIlGll	IPKhGLKHapllKDhKu.P-csL+lLlDSIpP.sLosAEsDFVslHLLEFNGKlpsppplDGasYclsDlYlC.Q.+LEFpapGpTFhF+sPthh.-pFhsls-hLpp....lplsD-sh....c..sFh-MPAFVhcWAs-IhoTlAlsGPNGsIpGlhsIlsl..........................	0	0	0	0
+10943	PF11111	CENP-M		Centromere protein M (CENP-M)	Pollington J, Finn RD	anon	PRODOM	Family	The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A [1]. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins [1]. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival [1].	25.00	25.00	25.10	25.40	24.00	24.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.95	0.71	-5.04	6	65	2009-01-15 18:05:59	2008-08-04 15:53:17	3	1	51	0	36	61	0	158.40	50	95.51	CHANGED	MA...lLRPaDKLPpLNsATlLLVGsE-uhppQLApuML+ccpsFplplHLApSLPLPs-ppphRPRIDLIVFlIsL+SKhSLpsVctSLsHLDssFFLGKVCFLlTGAGpssHCsVchsoVhKLAcoapSPllhs-hchEDhpsAhApRLLphLQICAGhVP.GVSALhLsoLhRsots	...................................MulLpPhsKhPtLN...sAolLLVGsE-thhppLA-uML.+..E.-ss...p..lpVHLAp.SLPLP..sp.ss....RPRIDLIVFVlNL+SK...a..SLpssEpSLpHVDusFFL.GKVCFLsTGAGptspsSl+hssVhKLApoYpSPlLas-Lcsc..shRsshAQRLl+hLplsAGhVP.GlSAL.L.shh+so..s................	0	9	12	20
+10944	PF11112	PyocinActivator		Pyocin activator protein PrtN	Pollington J, Finn RD	anon	PRODOM	Family	PrtN is a transcriptional activator for pyocin synthesis genes [1]. It activates the expression of various pyocin genes by interaction with the DNA sequences conserved in the 5' noncoding regions of the pyocin genes [2].	18.40	18.40	19.60	18.40	17.50	17.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.26	0.72	-4.15	26	221	2009-01-15 18:05:59	2008-08-04 16:51:16	3	2	194	0	36	165	0	74.50	34	80.92	CHANGED	TsahLhApa.upsllPl-cVsp-YF.pl.oscphhcKlpsGcIsLPlh+hc.sSpKus+hVplpDLAsYlDc+tptAc	...............phhhLhtca.ssshlsLptVspcYF.tl.ospshppKssuscl.slPshRls.sSp..Kuth...hVplpDLApYlDc+ppp............	2	6	10	24
+10945	PF11113	Phage_head_chap		Head assembly gene product	Pollington J, Finn RD	anon	PRODOM	Family	This head assembly protein is also refereed to as gene product 40 (Gp40). A specific gp20-gp40 membrane insertion structure constitutes the T4 prohead assembly initiation complex [1]. This protein in T4 stimulates head formation [2].	25.00	25.00	26.50	29.70	24.20	23.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.70	0.72	-4.08	10	33	2009-12-03 14:07:40	2008-08-04 16:51:44	3	1	32	0	0	25	0	55.70	46	51.23	CHANGED	VlQEllIh.c-GpsHLVYIaclpac...DGplplDauTss-t....K-ELtPHVccslphQI	.......VlQEIlIpLcDGssHIVYlpclcas...cG+lslDFuT.s--c...KsELuPHVEKClshQl...	0	0	0	0
+10946	PF11114	Minor_capsid_2	Minor_capsid; Minor_capsid-2;	Minor capsid protein	Pollington J, Finn RD	anon	PRODOM	Family	Most of the members of this family are annotated as being minor capsid proteins. The genomes carrying the genes usually have three similar proteins adjacent to each other, hence this one being named as No.2.	26.40	26.40	26.50	26.40	26.10	26.30	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.51	0.71	-4.21	5	120	2009-12-03 14:36:31	2008-08-04 16:51:54	3	1	116	0	15	97	1	109.60	29	94.67	CHANGED	M.h+IpVDLuGhKcKlSspuh+RG+lAlsNQhhhDMEQYVPhR..-GhLRuSu+lsSsGptIsYoTPYARAQFYGss....staph+NYTTPGTGKRWDhK..AKuhahuDWp+....AFlK.GMG	...........................tlhlcLs...t...hct...pl.p.p.uhp...+u...phtlsspshtshs.YVPhc.......sGpL.+s.o..u...p...l.sss..G...t..lhasssYARtQaYGss..................hphpphssPs...sGt+WDp+..ApsphhppW.c....sh.p.............................................................	0	10	13	15
+10947	PF11115	DUF2623		Protein of unknown function (DUF2623)	Mistry J, Coggill P	anon	PRODOM_PD065638	Family	This family is conserved in the Enterobacteriaceae family. Several members are named as YghW. The function is not known.	25.00	25.00	33.80	33.50	21.90	21.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.03	0.72	-4.05	6	450	2009-01-15 18:05:59	2008-08-04 17:16:34	3	1	449	0	21	54	0	94.90	86	99.75	CHANGED	MNNHFGKGLMAGL+AspAcoAsclspFCuDYKRGFVLGYoHRMaEpTGDRQLSAWEAGILTRRYGLD+EMVMDFF+EssSshAlRFFhAGYRLEs	....MNNHFGKGLMAGLKA............THAD........SAVNVTKFCADYKRGFVLGYSHRMYEKTGDRQLSAWEAGILTRRYGLD.KEMVMDFFRENNSCSTLRFFMAGYRLEN...................	0	1	4	12
+10948	PF11116	DUF2624		Protein of unknown function (DUF2624)	Mistry J, Coggill P	anon	PRODOM_PD060869	Family	This family is conserved in the Bacillaceae family.  Several members are named as YqfT. The function is not known.	20.80	20.80	20.90	21.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.73	0.72	-3.47	11	138	2009-01-15 18:05:59	2008-08-04 17:17:48	3	1	137	0	21	76	1	84.00	58	88.95	CHANGED	M.hlhQplVpQKLNplTsc-LL+YuKQYGlslTpsQAcplhsll+GKsINIFscsERp+llKclppITuPpTAppVNcLFpQFs.........s	......M.NLI+QlVNKKLNpIosKELLKYSKEY-VPITsuQA-QIVhLMKGKNINIYDssERLcLLKQIAKVTSPuTAQQVNsLFQQLl..K....	0	3	12	15
+10949	PF11117	DUF2626		Protein of unknown function (DUF2626)	Mistry J, Coggill P	anon	PRODOM_PD060869	Family	This family is conserved in the Bacillaceae family.  Several members are named as YqgY. The function is not known.	25.00	25.00	50.50	50.20	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.77	0.72	-3.57	8	157	2009-01-15 18:05:59	2008-08-04 17:19:28	3	1	157	\N	28	77	0	79.60	73	98.46	CHANGED	MDRMFRVLuFWTGIFAVMFYlGDMpssuLLFFGQTuhFlhLuYLpLSERMYlYIFGAYLTVFFlGFTYYSTFlhVPGhGc	.M-RMFRVLGFWTGIFuVMFYlG.............DM........ps.....sALLFlGQTGFFVLLSYLKLTERMYIYlFGAYLTVFFlGFTYYTTFlhVPGuGc.....	0	9	19	22
+10950	PF11118	DUF2627		Protein of unknown function (DUF2627)	Mistry J, Coggill P	anon	PRODOM_PD058321	Family	This family is conserved in the Bacillaceae family.  Several members are named as YqzF. The function is not known.	21.70	21.70	22.20	39.70	21.40	18.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.50	0.72	-3.88	13	153	2009-01-15 18:05:59	2008-08-04 17:19:58	3	1	153	0	29	89	0	77.20	61	95.06	CHANGED	MtRllALllLLIPGslAAlGIKLMRDolFGIlhsPFshL.......WLQFLuGllhFshGlhhlAGFILaRDRKRNKVssRF++	..MpRhlALLlhLIPhulAshGIKLMRDTlFGILh.s.....P.h.u...hL.......WLQFLlGhlhFulGhYlhGGFlLHRDRKRNKVQsRFR+.........	0	10	20	23
+10951	PF11119	DUF2633		Protein of unknown function (DUF2633)	Mistry J, Coggill P	anon	PRODOM_PD053432	Family	This family is conserved largely in the Bacillaceae family. Several members are named as YfgG. The function is not known.	20.90	20.90	21.50	20.90	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.91	0.72	-4.25	7	453	2009-01-15 18:05:59	2008-08-04 17:21:01	3	3	451	0	33	99	7	54.10	73	72.81	CHANGED	hR++hssphT+IlLLISFlhhFGRhlYuuIsAh.HHQp+.pu.phs.olp........pthpp	...KRHRFNoRMTRIVLLISFIFFFGRFlYSSlGAWQHHQsKKE.AQ.QSoLSVE....oP.......sQR.................	0	1	4	19
+10952	PF11120	DUF2636		Protein of unknown function (DUF2636)	Mistry J, Coggill P	anon	PRODOM_PD053231	Family	This family is conserved in the Enterobacteriaceae family. Several members are named as being YhjT, but the function is not known.	21.90	21.90	21.90	23.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-8.99	0.72	-4.47	8	456	2009-09-11 14:18:15	2008-08-04 17:21:37	3	1	452	0	25	86	0	61.90	80	97.67	CHANGED	MslSDIlQLlllCALIFFPLGYLs++shRRlRsThRhhhh+PRYVKPAGsL+Rs........o+V+uscp	...MTISDIIEIIVVCALIFFPLGYLARHSLRRIRDTLRLFFAKPRYVKPAGTLRRT........EKARATKK.........	0	2	4	15
+10953	PF11121	DUF2639		Protein of unknown function (DUF2639)	Mistry J, Coggill P	anon	PRODOM_PD049467	Family	This family is conserved in the Bacillaceae family.  Several members are named as being YflJ, but the function is not known.	21.70	21.70	21.70	25.80	19.80	18.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-7.90	0.72	-4.45	8	197	2009-01-15 18:05:59	2008-08-04 17:22:01	3	1	123	0	16	79	0	41.90	69	77.77	CHANGED	HaGSKGWYVcELKKhGIppaE..GRKLESYKsHhLuNLL..cph	............YaGoKGWYVtELKKLGlRhaE..G+KLESYRsHlLpsLLt...........	0	2	9	10
+10954	PF11122	Spore-coat_CotD		Inner spore coat protein D	Mistry J, Coggill P	anon	PRODOM_PD057197	Family	This family is conserved in the Enterobacteriaceae family. CotD is an inner spore coat protein that is expressed in the middle phase of mother cell gene expression. Along with CotD, CotH, CotS and CotT it is assumed to assemble into the loose skeleton of the matrix, between the shells of SpoIVA and CotE. Coat proteins do not share much sequence similarity between species, but this does not imply they do not share secondary, tertiary, or quaternary features [1].	19.60	19.60	20.50	20.40	18.60	18.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.48	0.72	-3.67	15	144	2009-01-15 18:05:59	2008-08-04 17:22:21	3	1	131	0	25	95	0	100.70	52	82.33	CHANGED	sslVHPT+pssscshscslVPHIHPsHTTpVN+phhcHhHYaPpTpSshspss..................ppahts..sss............................................G+sss	......APVlHPTKQCVsHoFSsTVVPHIaPTHTTHVaHQplK..sQpaF.PQTsSNVNsVs.........................................................................HsHpluPhs..P..ssssushGs..s.................h...........sss...............................................................................	0	6	15	20
+10955	PF11123	DNA_Packaging_2		DNA packaging protein 	Pollington J, Finn RD	anon	PRODOM	Family	This DNA packaging protein is also referred to as gene 18 product (gp18). This protein is required for DNA packaging and functions in a complex with gp19 [1].	21.00	21.00	21.60	50.20	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.62	0.72	-4.10	5	41	2009-01-15 18:05:59	2008-08-05 09:05:58	3	1	31	0	0	31	0	78.70	63	93.67	CHANGED	DKoLIKFLEMLDTEMAQRMLuDLpDDERRSPQLYNAIGKLL-RHKFQISKLpPDEsILGGLAAuLEEYsclVGssGLTDD-h	....hsL.phLEMLDTEMAQpMLtDLpDcE+RoPQLYNAIsKLLDRHKFQIuKLQPDhpILGGLAuALEEYpphVGssGLT-D-............................................	0	0	0	0
+10956	PF11124	Pho86		Inorganic phosphate transporter Pho86	Pollington J, Finn RD	anon	PRODOM	Family	Pho86p is an ER protein which is produced in response to phosphate starvation. It is essential for growth when phosphate levels are limiting [1]. Pho86p is also involved in the regulation of Pho84p, a high-affinity phosphate transporter which is localised to the endoplasmic reticulum (ER) in low phosphate medium. When the level of phosphate increases Pho84p is transported to the vacuole. Pho86p is required for packaging of Pho84p in to COPII vesicles [2].	23.70	23.70	29.40	133.80	20.00	23.60	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.85	0.70	-5.43	10	45	2009-01-15 18:05:59	2008-08-05 09:16:28	3	1	43	0	28	40	0	287.50	41	91.77	CHANGED	QKDssLNcPLDt-APPTltpoSLpPELApAuLsLpuDah+QtQuhhN+alFaHPlslollslslsshluhpL...as.hs.hSsols-.LYphhlhsK+-hlhsllhslsssuhlFuhluh.sahVoDthtchsschltpspsEpIFGhNL+cau............................spchsscs+cl.t........pscNTaIIlYR-oPIAllolssshspSoc-shlh+ITGltlR+ValKushh-sLIDWAhlRoRplhp-a.psK........upSlplllDsYSFDpphcKhLtp+GFphlp.ShcLss............clL.....ssLFGIo+-TaGlph	.QhDssLscPLDh-APPTIhsssLcPEhuoAALNLsuDal+QpQulsNKalhaHPlslsllslslhlals.+l...shPlp...o.s.Slst.hYplhhhNK+shlsullhohhssuhlFollut....loDsahppp.s.lstspuEplFGhsLpchs............................tpcpspcsh.............spNTcIIVYR-TPIAlISLssshs..lSoc.-shVhslTolGsR+VYlKSGIlEDLIDWAhl+o+slhpp...sK.......hupoh+LLlDlYSFDsshcchLcc+GFshlp.Shcls-.......................+LL..............GuLFGVp+-hWGlph..	0	3	14	25
+10957	PF11125	DUF2830		Protein of unknown function (DUF2830)	Pollington J, Finn RD	anon	PRODOM	Family	Several members in this viral family of proteins are annotated as lysis proteins.	25.00	25.00	46.90	46.40	17.40	15.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.76	0.72	-4.26	3	70	2009-01-15 18:05:59	2008-08-05 09:18:49	3	1	15	0	0	56	0	52.50	83	73.16	CHANGED	FKHEEYPCpcQQRSSTLYVLIsLAIFLSKFTNQLLtSLL-LLIRIVcTLQQLLT	.FKHEDYPCRRQQRSSTLYVLIFLAIFLSKFTNQLLLSLLEAVIRTVTTLQQLLT	0	0	0	0
+10958	PF11126	Phage_DsbA		Transcriptional regulator DsbA	Pollington J, Finn RD	anon	PRODOM	Family	DsbA is a double stranded binding protein found in bacteriophage T4 which is involved in transcriptional regulation. DsbA, along with other viral proteins, interacts with the host RNA polymerase core enzyme enabling initiation of transcription. DsbA acts as an enhancer protein of late genes in vitro. The protein consists of mainly alpha helices [1].	25.00	25.00	65.90	65.40	20.20	18.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.21	0.72	-3.89	7	36	2009-01-15 18:05:59	2008-08-05 09:23:25	3	1	35	0	0	26	10	68.50	52	76.26	CHANGED	hIpEASs.+hp.Euat-hlK-I+stAKpEhGl-GKhFNpLh+lYH+QpR-pFEsps-ElsplYDplFpt	.hIKEASDpKhplEuYs-hIKDI+p+AKcELGVDGKhFN+LlsLYHKpsR-pFEsEs-EllELYDslFs.t	0	0	0	0
+10959	PF11127	DUF2892		Protein of unknown function (DUF2892)	Mistry J, Coggill P	anon	Pfam-B_604 (release 23.0)	Family	This family is conserved in bacteria. The function is not known.	21.10	21.10	21.20	21.20	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.31	0.72	-4.14	172	1924	2009-01-15 18:05:59	2008-08-05 09:28:24	3	11	1526	0	602	1414	277	64.10	27	55.37	CHANGED	Mp...............NhGshDRhlRlllGlsllshshhsh.................thhhhhlGhs..hLhTulhuaCPhYtll.G...lsT.....sthp	.............................hpRhlpl.s.u..Gslll..huslh.uh..hst.......................hhhlsuhlGss..LlhsGloGaCsh...ttlL.p....h......p.h...........	0	191	418	532
+10960	PF11128	Nucleocap_ssRNA		Plant viral coat protein nucleocapsid	Mistry J, Coggill P	anon	Pfam-B_645 (release 23.0)	Family	This family of nucleocapsid proteins is from ssRNA negative-strand viruses of plant origin.	25.00	25.00	107.60	107.30	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.13	0.71	-4.80	5	129	2009-01-15 18:05:59	2008-08-05 09:33:54	3	1	10	0	0	80	0	178.00	68	65.42	CHANGED	RsLSKFIRETlF+-uDlcossLC-aLSSADPShFPASVFLKIsLDNLPTEVSSRCKMuIAGNKAIRYAlFApKF-.KDplusPTsussEslpEYlpKpEKLEKA+AIV-hLCSLuSNF-AQKKMHPLSPERoSRKNFTLQLTCAIVaSLSpcGRlDMRctI-ocKIEAFKRDENlYGctNu	.RKVPEFVKSKLY.DGDVSLSQISEELSHAPTKKFPARVFLKIDIDNLPSAVCSRCKLNIAGNRSVRYAGFASSFQTKQKLSPAVGATPESLMPLLETNQKIEKSIAIRDFLKTMEGQWKNQKRLHPLSDEKPTIKNFTLKLTCAIIYSLTPDGRIDMAERIITDKNKGFQNDRNFFGDGE.G..	0	0	0	0
+10961	PF11129	EIAV_Rev		Rev protein of equine infectious anaemia virus	Mistry J, Coggill P	anon	Pfam-B_124 (release 23.0)	Family	The sequence of this family is highly conserved and carries a nuclear export signal from residues 31-55, and RNA binding/nuclear localisation signals of RRDR at residue 76 and KRRRK at residue 159. Rev is an essential regulatory protein required for nucleocytoplasmic transport of incompletely spliced viral mRNAs that encode structural proteins. Rev has been shown to down-regulate the expression of viral late genes and alter sensitivity to Gag-specific cytotoxic-T-lymphocytes (CTL). Equine infectious anaemia virus (EIAV) exhibits a high rate of genetic variation in vivo, and results in a clinically variable disease in infected horses.	25.00	25.00	121.80	121.70	18.40	19.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.76	0.71	-4.17	2	322	2009-09-11 15:12:54	2008-08-05 09:34:35	3	2	4	0	0	217	0	132.90	91	96.22	CHANGED	PQtPL-sDpWCRlLRQSLPEEKIPSQTCIAR+pLGPGPsppssuRRDpWlRtQl.pAEsLQEpLEWRIRGVQQsAKEL-cVN+tIWRELpapccQ+GDauuassYpRtpEc+WGE.SSPRVL+PGDSKRRRKHL	.PQGPLESDQWCRVLRQSLPEEKIsSQTCIARRHLGPGPTQHTPSRRDRWIREQILQAEVLQERLEWRIRGVQQsAKELGEVNRGIWRELHFREDQRGDFSAWGsYQRAQER+WGEQSSPRVLRPGDSKRRRKHL.	0	0	0	0
+10962	PF11130	TraC_F_IV		F pilus assembly Type-IV secretion system for plasmid transfer	Mistry J, Coggill P	anon	Pfam-B_678 (release 23.0)	Family	This family of TraC proteins is conserved in Proteobacteria. TraC is a cytoplasmic, peripheral membrane protein and is one of the proteins encoded by the F transfer region of the conjugative plasmid that is required for the assembly of F pilin into the mature F pilus structure. F pili are filamentous appendages that help establish the physical contact between donor and recipient cells involved in the conjugation process [1].	21.80	21.80	21.80	22.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.23	0.70	-11.46	0.70	-4.93	71	713	2009-01-15 18:05:59	2008-08-05 09:37:15	3	7	493	0	136	633	29	242.30	22	29.40	CHANGED	stsphschLPa.....tpYsscsplal.....sspS..hGhhaElsPlsstscp......htctLpshlpp..sh..ssss..slQhhhhsssslsphlpp.hpshh...................ts............hhpphhtpphpaahcuht.p.t....sshsh......plRchRlhlhhphs.......tspsshpplpphpcpltusLpssGlt.spphsspslhsalhchh..NPpsshthss............Yst.p.................slspplhhssschcs.pp.shhhhs.....................t.scphlhshsl+phPct	......................................................s..sphschLPa.....hpY.......pp-..........splah.........sspo...hGhhh-hhPlsssscs......lh-slpphLps...chPcss....slQhhhh.s.s..s..plsshlcp.hhphhp.p................up................hhpchhttphtaahcuss.phth......pshsh........plRchRlhl.......hphs..............sthps.....pss...ht..phpplpcplp..u..uLtssulp.spphsupshhshltchh..N.sssthh.ptt..............phs..p..................slspQlh.ss.ch....cl.ct...shhhhs...............................t.spthlhshplpc.Pp...........................	0	28	67	108
+10963	PF11131	PhrC_PhrF		Rap-phr extracellular signalling	Pollington J, Finn RD	anon	PRODOM	Family	PhrC and PhrF stimulate ComA-dependent gene expression to different levels and are both required for full expression of genes activated by ComA, which activates the expression of genes involved in competence development and the production of several secreted products [1].	25.00	25.00	26.10	43.40	23.60	17.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.64	0.72	-4.38	4	36	2009-01-15 18:05:59	2008-08-05 09:44:28	3	1	21	\N	6	17	0	37.00	62	95.28	CHANGED	LKSKLhlhCLAhusVFsussl.ApAspppFcVApRGMh	.LKSKLFVICLAAAAIFTAAGl.AsA-tt-FHVsERGMT	0	2	2	2
+10964	PF11132	SplA		Transcriptional regulator protein (SplA)	Pollington J, Finn RD	anon	PRODOM	Family	The SplA protein functions in trans as a negative regulator of the level of splB-lacZ expression in the developing forespore [1].	25.00	25.00	29.20	29.10	21.70	20.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.57	0.72	-4.23	7	78	2009-01-15 18:05:59	2008-08-05 09:46:18	3	1	57	0	13	43	0	66.80	50	92.81	CHANGED	Mph....psapsGD.VYVIYRNPHstsVApIpEAtlVpHP.c.sELALFLaETYaPlspD.AlFso.-pAEphYpphFc	...............p.apsGD.VYlhYRNPHstsVApIppAElVsHPp+cGELALFLaETYHPLu--DAlauo.-EApphYp.hat......	0	3	7	9
+10965	PF11133	Phage_head_fibr		Head fiber protein	Pollington J, Finn RD	anon	PRODOM	Family	This head fiber protein is also refereed to as Gp8.5. Gp8.5 is a structural protein in phage. It is a dispensable head protein.	20.60	20.60	20.80	20.80	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.77	0.70	-5.20	3	66	2009-01-15 18:05:59	2008-08-05 09:51:36	3	3	62	1	12	64	7	123.30	22	66.00	CHANGED	MhsSFTAhANSsIlAY+LLsalEuE-pIEISaAcEcTIP-YVul+DLcsGDhTslshYPLAAWpVIAsSDIslG....D+lTTGKNGTlKhTcDspssFGYAVupApcGQLVTlI..IS+uFDplIpsDDlG-ssDsGphLhchssssGspshlI...DsKAhlpuNoTssNKKpLcD.LLlSsLsVKAF......LsusToD-NKANL............cpLhVSNPclLuhLsGsPSoEsKssLRoMIGAGsPYTLPAATTTTLGGVK+uAAVusSTATDVssuVKDFNuLLTALKNAGIIu	........................................................................................................................................................hs...................................................................................................................................................................................................................................................................................................................K..ph.st..........ss...uo.u.ssstshhtphNsllstL+suGhh................................................	0	3	7	8
+10966	PF11134	Phage_stabilise		Phage stabilisation protein	Pollington J, Finn RD	anon	PRODOM	Family	Members of this family are phage proteins that are probably involved with stabilising the condensed DNA within the capsid [1].	19.70	19.70	21.50	21.10	17.20	16.60	hmmbuild  -o /dev/null HMM SEED	469	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.71	0.70	-5.92	3	145	2009-12-03 14:24:52	2008-08-05 10:02:23	3	2	137	0	6	107	10	449.10	82	97.02	CHANGED	hQLPLhKGLGKDhKsADYIDALPVNMLATPKEVLNASGYLRSFPGIsKKsDVsGVSRGVcYNT+pNAVYRVCGNpLYKG-KsVADlAGpGRVSMAHSRsSQAVsssGKlpLYRYDGTVKTLSNWPKDKtYTQYDLGsVRDlCRLRGRYlWsKDGoDpFGVTDLEDESHPDRYpAhYRAESQPDGIIGIDSWRDFIVCFGSSTIEYFSLTGAADsuuALYlAQPALMVQKGIAGTaCKTRauDuYAIISHQATGAPSVYLIGuGQAosIATATIEKIIRSYTADELAouVMETlRFDSHELLLIHLPRHVLCYDASASQNGsQWSLLKTGFYD-PYRAIDFMFtDNQITCGDKsEuLLGQLpFsuSuQYEpQQEHLLYTPLFKADNARlFDFELEASTGVAQIADRLFLSATTDGINYGREQMIEQNuPFsYDKRILWRRlGRVRKNIGFKlRVITKSPVTLSGCQIRME	...........................................QQLPLMKGVGKDFRNADYIDYLPVNMLATPKEILNSSGYLRSFPGIAKR.SDVNGVSRGVEYNMAQNAVYRVCGGKLYKGE....S.....E..V....GDVA..GSGRVSMAHGRTS...QAVGVNGQLVEYRYDGTVKTVSNWPs...DSGFTQYELGSVRDITRLRGRYAW.SKDGTDSWFITDLEDESHPDRYSAQYRAESQPDGIIG.IGTWRDFIVCFGSSTIEYFSLTGATTVGAALYVAQPSLMVQKGIAGTYCKTPFADSYAFISNPATGAPSVYIIGSGQVSPIASASIEKILRSYTADELADGVMESLRFDAHELLIIHLP..R..HVL..VYDASSSANGPQ..WCVLKTGL..YDDVYRAIDFlYEGNQITCGDKLESVTGKLQFDI..SSQYDKQQE.....HLLFTP.LFKADNA..R.sFD.LEVESSTGVAQY....AD.RLFLSATTD..GIN.YGREQMIEQNEPFVYDKRVLWKRVGRIRKNlGFKLRVITKSPVTLSGCQIRIE......................................................................................................	0	2	2	2
+10967	PF11135	DUF2888		Protein of unknown function (DUF2888)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family of proteins with unknown function are annotated as immediate early protein ICP-18 however this cannot be confirmed.	21.50	21.50	21.60	262.10	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.87	0.71	-4.48	2	13	2009-01-15 18:05:59	2008-08-05 10:27:34	3	1	13	0	0	11	0	143.20	81	92.36	CHANGED	GcPapppGshh.lPFupsFTIDLVNh.hpoEhpV+lpMoPphslGTFVVtPKphFSI+RAspGDAuFKVtRutGW.spT.QsLohhhYcR...l-hcsGs..pplETDG..GTVlVPGcsTGQRFupAhAh.hhFLap+.FllpGV	GEPYTCKGDLCEIPFuRNFTIDLVNLSVSTEFQV+ITMTPHHDLGTFVVEPKKVFSIKRAsKGDAAFKVtRAAGWLPDTPQVLoLFVYERLpPVEWHStChYENLETDG..GTVIVPGEATGQRFGTATAVPThFLFKRMFVVKGV	0	0	0	0
+10968	PF11136	DUF2889		Protein of unknown function (DUF2889)	Pollington J, Finn RD	anon	Pfam-B_001473 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.80	20.80	20.90	25.00	20.00	16.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.27	0.71	-3.89	49	270	2009-01-15 18:05:59	2008-08-06 10:06:50	3	2	200	0	113	274	147	120.40	34	54.07	CHANGED	HpRplphpuat+.p........DGLa-l.EuplpDsps.s.s........h.sspslHchplplTlD.sshpIhsspAphctsPas.hCspsssshppLlGhslu.Ga+cplpcpluGspGCTHLpELLt.slussAhQs	..................HpRtlphcuYtR..s........DGLa-l.EApLpDpKsh-hs..t...thh.sutslH-hhl+lTlD.pchslhcscA.shchsPas.pCssussuhptLlGlslt.tsaR+plpctLuGssGCTHLsELht.slsTsAhQs.........	0	25	62	89
+10969	PF11137	DUF2909		Protein of unknown function (DUF2909)	Mistry J, Coggill P	anon	Pfam-B_764 (release 23.0)	Family	This is a family of proteins conserved in Proteobacteria of unknown function.	28.30	28.30	28.40	32.20	27.00	28.20	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.07	0.72	-4.23	51	339	2009-01-15 18:05:59	2008-08-06 10:14:11	3	1	327	0	118	287	343	64.30	35	88.64	CHANGED	hKl.llllhllsIlsSLsSALaFLh+D...pu...........cupRhs+uLshRVuLSlsLhllllluhhhGhl....pP	...h+l.llllhhlhIlsSLsuALaahh+D..cG............popRhlpuLshRVuLSlsLhlhllhAhhhGhI......ss.....	0	22	62	92
+10970	PF11138	DUF2911		Protein of unknown function (DUF2911)	Pollington J, Finn RD	anon	Pfam-B_001491 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.90	20.90	21.80	23.40	19.60	18.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.90	0.71	-4.57	69	234	2009-01-15 18:05:59	2008-08-06 10:24:24	3	10	92	0	137	269	303	145.40	35	62.05	CHANGED	SPtspstt..........pl.uhsc......lplpYSRPuh.....+GRp..IF.......Gs...LVPYG...........cVWRTGANpsTplshscDltlsGcpltAGsYuLaTIPsccs.WslIhNp......sts.pWGs.........pYc..ppcDll.Rlplssp.phs..pshEphohshsshpsst.uhlpltW-pshVslsl	.......................SP.spspt......ph.uhsp...lplpYSRPuh......+GRp..IF.......Gs.....L..VPYG..............clWRTGANpuTplsFscDVpluGctltAGsYuLaoIPscsp..WslIh.Np.......shs.pW.Gs........hpYc..pspDllRlpVtsp.phs..p.hEsholsh...sshssst...upltltW-pstVslsh..........................	0	68	117	136
+10971	PF11139	DUF2910		Protein of unknown function (DUF2910)	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_001487 (release 23.0)	Family	Some members in this bacterial family annotate the proteins as cytochrome C biogenesis proteins however this cannot be confirmed. Currently no function for this family is known.	31.00	31.00	31.00	31.20	30.90	30.90	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.33	0.70	-5.20	46	566	2012-10-02 18:22:22	2008-08-06 10:24:54	3	2	322	0	120	408	26	215.20	21	94.89	CHANGED	lLshAlslulsPhplshslLlLpp.....s+PhhphlsFlsGhhlsshslsslhlhlhcsls......shpts.......sstthshlplllGssllhlushhhhpt..................................................tststhsphhsphp.....shs.stuhhhuhlhslhps.tshl.ahsAhuslsuuuhssssphsAllsFsllussslhlPLlualluspR..spshLtpl+sWhpsppphlluslhsslGhhllhp.Gls	....................................................llshAlshulsPhhlhs..s..l...l..h.....lpp.........scsh...p..h..hsFlsGhhlshsu..lshsslhhhsshs........shstt.........sphssshlp.lllGllLllhushhhtpp.................................................................................httsthsph..hpphp..........sht..sss.s.hh.huhlhsl.sps.tshh..hluAhshIsuushshssphhshlhFsh.l.shss.shlP.llual..ht..sp+....h..pthhtthp..sW..hp..p..p.pth...hh.shlhhhlGhhhlhpul.........................................	0	35	83	107
+10972	PF11140	DUF2913		Protein of unknown function (DUF2913)	Pollington J, Finn RD	anon	Pfam-B_001499 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.	20.40	20.40	20.80	20.50	20.20	19.70	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.19	0.70	-5.03	24	383	2009-01-15 18:05:59	2008-08-06 10:47:32	3	1	273	0	51	246	3	190.00	28	91.67	CHANGED	sYsptlhclspsuLspLptpp.psupshpsssscsHaLspWlspALKppRFs+hluc..sLptW.+puRShGssApLctlhp+Ipt.Yt....sstp.tpshstsplcuhLsplcptsWhVtT....-p.lss..KlplpoDGpsSLl.lsupphpppFss..spLlKPlohalRG...scpthhptAhppGhhlaphschpShVKaHt-YhlaPtNptstLspL..s	..........hp..lppll.sALstLpttp.cst.p.t.h.s.u.stpscaLlcWlspAlKpp+Fp+hlsc..cLpthhctu.Rsh..ust..upLtshhph..........sspp.tt.hshhclcuhLsphcptsW..p..lts......sp..lsp....plphh.ssGpss.Lh.lptsph-psFss.....schlpPlshhlpu...ph.t.thhpthhtsu.hh.p..c.t..lhhthph.h..tt.......l...........................	0	3	12	32
+10973	PF11141	DUF2914		Protein of unknown function (DUF2914)	Pollington J, Finn RD	anon	Pfam-B_001640 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.70	20.70	20.70	21.90	19.80	20.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.48	0.72	-4.45	39	174	2009-01-15 18:05:59	2008-08-06 10:47:56	3	2	158	0	77	178	90	68.50	36	22.50	CHANGED	pu..pt.lhHhWh......pssc.ssclsLslp.GsR...aRsaSpKphh..stsGcWcVcVhspsGpllushcFpls	..................ppplhHlWh..........tsGcphs+Is...LsIp.GuR...uYRsWopKpshs...sssGc.WpVcVloE..s..Gp.hIuslcFpV....	0	29	52	69
+10974	PF11142	DUF2917		Protein of unknown function (DUF2917)	Pollington J, Finn RD	anon	Pfam-B_001647 (release 23.0)	Family	This bacterial family of proteins appears to be restricted to Proteobacteria.	25.00	25.00	25.10	25.00	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.97	0.72	-4.78	40	253	2009-01-15 18:05:59	2008-08-06 10:49:20	3	3	129	0	98	236	21	65.20	30	55.56	CHANGED	tapLs.sGpshsh+stpssp.LpVt..sG...plWl...Tt.-u.......s.....spDaWLpsGpoLpLtpGp+lhluut...hssu	..................atls.stpshsh+..ssp.ssp...LpVp...sG..........tlWl...Tp.ss........c.....scDaaLpsGpslcltcGp+..lhlout..h...ss...............	0	9	40	68
+10975	PF11143	DUF2919		Protein of unknown function (DUF2919)	Polllington J, Finn RD	anon	Pfam-B_001684 (release 23.0)	Family	This bacterial family of proteins has no known function. Some members are annotated as YfeZ however this cannot be confirmed.	22.70	22.70	23.00	23.60	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.71	0.71	-4.37	29	662	2009-01-15 18:05:59	2008-08-06 11:06:50	3	1	644	0	64	283	15	137.30	54	96.12	CHANGED	as.ls.aDc+GplKsPlhhahsLlaLARuWslFlhusssRpstssLLplFYP-+ssFaluLssGlsAlLhh.llhucRp....ct.phlt..laphh+hhLlhslllphshhhhtlhhpthhashshulphllhhWhhlYLhpS++Lpthhpshpp	..............at...pYDspGhL+hPhhhWh..sLLh.ARsWVLF.VIAGuS.REQGosLLNLFYPDHDNFWLGLlPGlPAVLAF.LLSGRRs....shPp......lW+hLh.hLLLLAQlV.LCWpPa.lWLsG....-....uVoGlGLALllADIVALIWLLTNRRLRACFst...c....................	0	6	16	41
+10976	PF11144	DUF2920		Protein of unknown function (DUF2920)	Pollington J, Finn RD	anon	Pfam-B_001778 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.70	24.70	24.70	24.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	403	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.35	0.70	-5.45	20	738	2012-10-03 11:45:05	2008-08-06 11:26:01	3	2	129	0	22	553	3	187.50	29	98.00	CHANGED	NpTapIDSCDDVELsIKR..pSKLEaRloYDDpK-IKAIVhIIsGhGuDss.sahcahpcalA+pacVsslsVsYHChssR....sphuAphhh-c.DhhllcssLcslsl....shtslss.cphpphhphLspplpphKppshlspsapLp.LSsohhPscsEYQNFGIMtAlDllNAlhalh+c..........hsphus......lPpIhsGuSYGGYLApLsAKIAPWhlDuVlDNSuhAh...shhchI.hG+El-a.ph.ptush...hp..slplthasKTaWTp.scsSsaaFussphhIRslLNpcHLpIQupa..pshYloYHShpDphs.Psc-KpphachLcpLGFDssLplIpcEspIDG+FIKsL-HGhGlohKtLh+KcLPhlLEKl.shpsch..pc.cpISYPCc-hlYpFc-pscKlpLcI	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	10	14	19
+10977	PF11145	DUF2921		Protein of unknown function (DUF2921)	Pollington J, Finn RD	anon	Pfam-B_001920 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	18.80	18.80	19.30	18.90	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	909	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.63	0.70	-13.66	0.70	-6.83	7	137	2009-01-15 18:05:59	2008-08-06 11:43:06	3	5	21	0	96	115	0	572.50	24	90.89	CHANGED	Y......pp+Cps..stus.h...s.sststhhuppl.h.pssah..uGssslhshssspsh...........+.soFssppl.....t+s+sst.hlpVsuhLsLt....uspsshhshsht.pp.ph.hlst.........ph.hpGhYoE............upt.LCMVGsu...................sshus-ssslhh.tshlLhLphPKs.oLssphVpGpLcSssthsp...F-slpLluh.pp..pY.a.....pLs.tt..C.....cPhs.t.cthh.tupusps..h.tthCclLcch..t...shpl..shc.Csuoc.hsshhsshph............tshthhhpsl+Cps.t.......sss+s.lsFpshos.Eph..hs...t.t....ptoLsAEGhWcsosupLChsAC.lup.s.....sthhsts.CphRlSLpFPssaSIRsRShllGplhssss......sptshuFcplh.s.....pshppph.phh.h+YsYTcl-cAtchhtps.c.ush.....++...spaPts.t..........ShSDht.choh+hsut........upu.........sshslGshhhp....h..hutsphsshss.h....scshslpppp..LLNVShcIoh.................ossh.hppstlShEGlYDpcsGphhhlGCRcl.ph..p...s......tsuhDCpI.lplpasslsu+..spsph+spIpSpR.tcsD.LaFcthclpspshhh....c.ph.-sl.RhslEslhsllohThShshhshQLhah+pps.-shPhlSlsMLsl.ALGahhPLlhshEALFh....stppp.h...........hptsthhps.-hhl+llTllsFLLpLRLhQhVWpuRtps.pppstc.t..su-++sLhlsLslYlhGhlluhhlphstsph.hstt.ps..............u.p.tshhp-ltpYsGLhhDhFLLPQlIhNuh.pscs+.PLushFYhGsThlRhhPHsYDhhRupshsshhp..ssahaAssph....DaaupAhDVllPlsAhhLAhllFlQQRashthlh.t	...................................................................................................................................................................................................................................................................................................................................................h.s.h.s............................ta.a..............t...............................................C....h.......................................................................................................................................h..s-G.ap...ts.h.h.uC..h..................t.Ct.thph.h....hohptts..hG.h.s.t...............h..........................YpY..o.hp.stt.h.t......t......t......aP..................h...h..t.......................................h..l...h..................................................................hth..sh.h......................................h.hEGha....G.h.hluC..h...................t.DC.l...l.hths..t.........h..h.ItS.R..t.sD..hh...hth....h............................t..t.h.+...h-.hh.hh..sh.hhh.h.Qlhahpt.s..p..s...hSlhhhhh.shGh.h.Lhh.s.t.hhh........................................t........p.hh+h.hhhthhh.hplh.hsht.+.......t.......................sc.t.shhh...hahhhhhhhh..p........................................h.tahGlh.DhFLlPQllhNh.h.....t..p.p..slt..aYhGhThhRhhP+hYchhp........................s.t.....shash..hhDlhlshhsh.huhhlahQQphs.......p..................................................	1	4	55	82
+10978	PF11146	DUF2905		Protein of unknown function (DUF2905)	Mistry J, Coggill P	anon	Pfam-B_542 (release 23.0)	Family	This is a family of bacterial proteins conserved of unknown function.	22.20	22.20	23.90	23.90	21.70	20.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.18	0.72	-4.03	79	498	2009-01-15 18:05:59	2008-08-06 11:50:21	3	1	488	0	217	396	105	63.30	39	91.19	CHANGED	hu+hLlhhGll.llllGhlh....hl.t+.....hs.l..GRLPGDIhlcctshsaYFPlsTsIllSllLSllhhlh	........hs+hLlshGll.LlllGlhh....al.t+..........hs..h...GRLPGDIhlc.+s..NhsFYFPlsTslllSllLSl..lhhlh....	0	80	152	189
+10980	PF11148	DUF2922		Protein of unknown function (DUF2922)	Pollington J, Finn RD	anon	Pfam-B_001999 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.70	22.70	22.80	23.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.89	0.72	-4.32	49	773	2009-01-15 18:05:59	2008-08-06 11:52:37	3	1	650	0	145	467	0	68.00	28	90.76	CHANGED	KpLpLsFpsssG...Kphslslsssp-slotsplcssMspllspslFtssuG.sL.sshpuA+lV-psssslh.	.........KsLcLsFpssts....Kssplplspspss......lT....pp.lcssMssllstslhpss....s.u.sl..sphpuApll-+ssosl...................................	0	71	119	135
+10981	PF11149	DUF2924		Protein of unknown function (DUF2924)	Pollington J, Finn RD	anon	Pfam-B_002010 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.80	21.80	22.00	24.10	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.59	0.71	-4.15	31	178	2009-01-15 18:05:59	2008-08-06 12:38:05	3	5	96	0	88	183	81	132.10	37	82.95	CHANGED	lhs....clAtLsshshscL+thWpclas.stssphs+saLppRLAYRlQEhsaG....GLsppscp+L-plucptp.tphht......................ppsspphssGTpLlREWpGhpHpVtVhsDG.F-apG+pa+SLSAlA+tITGTRWsGPtFFGL+	..........................................................................................h..tplAtLtshshscLpthWpclas.ptssp.hs+paLpp+lAYRlQEhshG....GLstpspp+Lctlucphsttthht..............................ttsstt.hsGThLlREWpGppHpVhVhs-G.F-apG+hacSLSAlA+tITGT+WsG.hFFGL+...............	0	43	68	79
+10982	PF11150	DUF2927		Protein of unknown function (DUF2927)	Mistry J, Coggill P	anon	Pfam-B_739 (release 23.0)	Family	This family is conserved in Proteobacteria.  Several members are described as being putative lipoproteins, but otherwise the function is not known.	20.40	20.40	20.90	21.30	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.15	0.70	-4.65	65	243	2009-01-15 18:05:59	2008-08-06 12:55:41	3	1	191	0	58	212	104	206.30	34	67.68	CHANGED	sssplscsFhclAhttEYsps............hstlpRacsPl+ltlp...usssuspstDhstl...lsRL...uclsGhsI.shsss..........pANlplhhssccc.......l........pchlPpsustsls.h.shsctthChststsshsp.hptspsllhl.s-psshhhtsClHEElAQuLGLhNDo.clhsSlFNDD.s.aulLTsaD.lLL+hLYcPcL+sGMohs-ltshL.tl	.........................................................................................................s.ss.ltcsFhplAhpsEYstu...........tphlp+Wc..tP.lRlhhc...........ttssc+shctphltsalp+L...uplTGhsI.phsss...........pANlhllhsppsc...ht.tl............................cchhspsustsh........csshChsshps.s.s.s.s.phstuplllsVcpspsct.chluClhEElsQslGLsND..Stp...s...hPSIFNDc....s.pslLoshDhlLL+lLY-PcLcsGMotsplpslLp..h....	1	11	31	45
+10983	PF11151	DUF2929		Protein of unknown function (DUF2929)	Pollington J, Finn RD	anon	Pfam-B_002101 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	21.90	21.90	22.90	22.30	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.78	0.72	-3.89	28	624	2009-01-15 18:05:59	2008-08-06 12:57:35	3	1	618	0	61	231	0	57.20	33	90.30	CHANGED	M+Y....llshFWohlLsphlsalluuLsus.sas...hhsssIluVlhulllhllss.llstcss	.........M+a....llohhWuhlLsphlsalluSLsGG..oas.........hsps.hIhuVlhsllhhllus.slsspp.s.........	0	14	33	49
+10984	PF11152	DUF2930		Protein of unknown function (DUF2930)	Pollingtin J, Finn RD	anon	Pfam-B_002135 (release 23.0)	Family	This family of proteins has no known function.	23.10	23.10	23.40	23.20	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.10	0.71	-5.15	30	160	2012-10-02 14:34:25	2008-08-06 13:06:36	3	4	101	0	74	152	122	170.80	32	78.48	CHANGED	lsLhsGsLshsLhllNp.lss....ssloPu.pRA-VLuslhussLlLlulLWpphpP+.ss-tVsLpG..cpGhtlsssLspul+pELAWuSchLLTsTsssolLlaa.cGplLLRRGll............sss....phpPGsIspRshcppp........sl.LVNhtLYPGRs....EF-...hlPsNh.uVllQPLGsc...........GhlllGuhosRsFo+pDEpWlsGhA-KLc	...............................................LPlhsGshshhhlLlN+..lss..........sphos.uQsRu-lLulhLuss.lLsullWp.plp..........P+.u.......s....ssVsL.G........ppsh.hsssl..sp..shppELAWuo.hLLpsT.sstulllhh..ps..phllphGhh......................s...........phh.sthhppshpp.tt..................Lssh.haP...u+.........Eht........hlP.sh.ull.hQ..Plspp............Ghllluups.RuaoppDctWltshupKl...........................................................	0	20	50	66
+10985	PF11153	DUF2931		Protein of unknown function (DUF2931)	Pollington J, Finn RD	anon	Pfam-B_002146 (release 23.0)	Family	Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently, there is no known function.	22.20	22.20	23.10	23.70	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.28	0.70	-5.00	30	307	2009-01-15 18:05:59	2008-08-06 13:16:21	3	2	183	0	64	250	1	193.90	24	84.36	CHANGED	hphlhhll.hsL...lsuCssssh...............p.hpWphusshPpthsshVspsthhstscps..h.ts.sshs.....pp.ttt..tWsst........t..suh.sscspslPchlhlpWhSlh-pKtYppplpl..PcslpppMtpstphpspts.h......hRsslllGLAPGGhVpVWLps...tstsslhls+hpApplsss..phh.......phshshsph......pcpppsalcpcslPhG	......................................................hh...hh...h.uCtt.......................tW.hsh.hhPphhP.s.VThshh..hsspt.h....h.p...s.......p..tt...hspasth.............t...hstspphPpplhhhW.sSlhDpKhYpTchtl..sps.ltphhhs......hshsptss.hh............ahsphlhGLsPsGplpVWLps....stpslhl.s.pht.......pplpscc.shsK........t.p.h.h..............tthtshlc.cshPhs................................................	0	9	34	45
+10986	PF11154	DUF2934		Protein of unknown function (DUF2934)	Pollington J, Finn RD	anon	Pfam-B_002301 (release 23.0)	Family	This bacterial family of proteins has no known function.	19.80	19.80	20.50	20.20	19.60	18.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-7.88	0.72	-4.59	64	414	2009-01-15 18:05:59	2008-08-06 13:46:20	3	11	258	0	181	424	25	39.60	35	34.70	CHANGED	tpp.p-cpIRcRAYplWEpcGpP.pGpspcaWhpAEpplpup	..........ttcccpIRctAYplWE.pcGpP..pGc..sp..caWhpAcpplct......	0	44	82	116
+10987	PF11155	DUF2935		Domain of unknown function (DUF2935)	Pollington J, Finn RD	anon	Pfam-B_002056 (release 23.0)	Domain	This family of proteins with unknown function appears to be restricted to Firmicutes. The structure of this protein has been solved and each domain is composed of four alpha helices. A metal cluster composed of iron and magnesium lies between the two domains.	21.20	21.20	21.60	21.20	20.80	20.40	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.68	0.71	-4.03	73	699	2009-10-15 12:33:13	2008-08-06 13:51:02	3	4	223	52	132	510	4	123.20	30	85.59	CHANGED	hhppslcpchFWhcIhtEHuhFIpssLsspE....pcllppAcpFtpp.F-pLhtcuhphssth.............................................................tlpplspcshp.tspplpsFKpplhcthlss+l.hshhhPLhhDHhlREupaYlphLpp	..............................................................ptlppphFWh+lht-HuhFlptsLcspE..........pcLlcpAppFtpp.F-.plhtpuhphps.h.................................................................tlpph.spcspt.tspplppFKpplhphh.lps+l...tshhhPhhsDHhhREsphalphLp.h....................................	1	53	112	117
+10989	PF11157	DUF2937		Protein of unknown function (DUF2937)	Pollington J, Finn RD	anon	Pfam-B_002314 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.30	25.30	44.30	30.20	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.92	36	166	2009-01-15 18:05:59	2008-08-06 14:10:53	3	1	162	0	56	163	20	162.70	29	95.05	CHANGED	hlhchLclhhhs....sGslhusQhPtFsppYtQRLsuplpEhppslssFptsAppa.ssshpphltpappss-.hhpscupshpphhsRhptLppshpth..pus.ap+hhhhhphschclhppThpsap.ulsLospulsaulssullhs.hlhthhhtlhthhht...+pppp	....MltphlcLllFs....hGhlhulQlPtFhspYtQRlsutl.EsppslpuaptoAppahtsshpthlp+apsssDsshpscupshpphhpRhphLppphtsh..pushat+shahhpsschclhppThssap.tl.Lss-ulsaGllsuLlls.hlhchhhhlhshhhp..tt.............	0	12	28	39
+10990	PF11158	DUF2938		Protein of unknown function (DUF2938)	Pollington J, Finn RD	anon	Pfam-B_002317 (release 23.0)	Family	This bacterial family of proteins has no known function. Some members are thought to be membrane proteins however this cannot be confirmed.	23.00	23.00	23.10	23.10	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.96	0.71	-4.87	36	258	2009-01-15 18:05:59	2008-08-06 14:19:11	3	1	249	0	69	220	189	145.00	41	88.88	CHANGED	lhIGlGATllMDLWullh++lhGlsshsaAhVGRWlsHhh+G+hhHpsIupussV..tuEphlGWhsHYhlGlhFAslLlslhG.sWltpPTlhPAlhhGllTVssPahlhQPuhGhGhAAS+TPpPhpsRlpS.....LlsHslFGLGLYluAhhl	...................................lhlGlGATllMDlWuhl...hphh.Gh..sshsauhVGRWhh.al.h+Gp....lhHs..sIupusPh....ttEhslGWhuHYulGllauhlhhhls.Gss...WhspPshhPAll.hGl.l.T.lsAsaFlhQPuhGhGhAAS+sPpPsts.R..lho......LluHssFGlGLYhsAhh.h...................	0	16	37	50
+10991	PF11159	DUF2939		Protein of unknown function (DUF2939)	Pollington J, Finn RD	anon	Pfam-B_002321 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.50	21.50	21.70	21.50	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.87	0.72	-3.81	35	245	2009-01-15 18:05:59	2008-08-06 14:27:23	3	2	210	0	84	227	37	94.70	26	44.55	CHANGED	slsshsshhhuSPYl....ulaplcsAlcspDstsluphlDaPuLRpSL+sQlssthhpph....ssphtssshusLuthhus.ullssh....VDshlTPpGltslh	.....................lhssh.hhh..hu...oPah.......sLtplppAlcs+Ds....sslspaVDaPu.lRtSL.+...pQlsstlhpph.....ssphpsssh....s.tlut.hlus.....slsssh.......VDshlTPpulsth.........................................	0	24	48	66
+10992	PF11160	DUF2945		Protein of unknown function (DUF2945)	Pollington J, Finn RD	anon	Pfam-B_002448 (release 23.0)	Family	This family of proteins has no known function.	20.60	20.60	20.60	20.70	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.68	0.72	-4.15	31	280	2009-01-15 18:05:59	2008-08-06 14:57:41	3	4	259	0	131	297	20	61.40	36	61.29	CHANGED	GD+VpW......sScsGcspGplhchpTc-schpG..+phcASp--PQYclcSDKTs+hAsHKssuLp+h	..........GDcVpW.............sSpsGpspGplhc....h....h..T..c..cs....c..h..p..G..+..s.....h..c..ASpD-PpYp...lcS-+os+.AsH+spsLpc.h...............	0	35	77	107
+10993	PF11161	DUF2944		Protein of unknown function (DUF2946)	Pollington J, Finn RD	anon	Pfam-B_002487 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	21.60	21.60	21.60	22.80	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.50	0.71	-4.62	41	142	2009-01-15 18:05:59	2008-08-06 15:05:40	3	1	141	0	58	133	19	185.90	47	96.43	CHANGED	MD-IV+pAlAKWPNVPsCaGWLuLDtRGpWhhRD-t.sQ.....ttG............h.Gs.lpHssLlsFIsRNYpsDtcGpWFFQNGPQRVYVEL-hTPalhRlps......t.s........hslpsHTGt..sht.spusalDEpGplhLs...................sshtluLlHD+Dlshhustsp...t...s................................ttplslps.ltpu-lstRFGFVtsPtst	...............MDDIV+QAlAKWPNVPpChGWLhLDcRGpWRhRD-tAQ.....AsG.............t.GsPlRHsuLlsFIsRNYppDtcGpWFFQNGPQRVYVELshTPWllRLsst......ss.......................huLssHTGt..sh..p.sstsaLD-tGsllhs...................ss.plAhLHD+DLshhuctscht.t....ut.s........hhth.s........................stshsl.psltps-VstRFGFVssPAtt...................................	1	7	30	46
+10994	PF11162	DUF2946		Protein of unknown function (DUF2946)	Pollington J, Finn RD	anon	Pfam-B_002520 (release 23.0)	Family	This family of proteins has no known function.	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.01	0.71	-3.91	87	687	2009-01-15 18:05:59	2008-08-06 15:45:01	3	3	389	0	224	685	20	122.20	19	86.11	CHANGED	suW....lul..hAl...Lhthl.APhlupuhh........thstssh...ssshCssssst....tsshstststptsss.t.................................sC...saCshhstss......sLssshsshhshhhthtths.......sshhtshsstthassups.RAPP	..................................................h..luh...hAl...l.h.h...hl...uPhlupshs..............................stssh......ttsh.C.ssssst.............tsshstsss.t.pts..st.t..t.tt.....................................sC...saCs..h.hst.s......sLs.ssh..ssh.h.s.hh.hhhst.hs.......sshhhshh..tt.hast.sps..RAPP.................................	0	35	85	163
+10995	PF11163	DUF2947		Protein of unknown function (DUF2947)	Pollington J, Finn RD	anon	Pfam-B_002524 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	26.30	25.80	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.96	0.71	-4.64	22	169	2009-01-15 18:05:59	2008-08-06 15:50:15	3	1	168	0	34	105	7	151.10	56	96.65	CHANGED	YlPL-pYpRKWIFsHpshPVss-DhApIKPhoptRAsplWpcaISspSscs-pFscsDWss+sssWhps...cWpuAWDS.--ssLP-tlhtalc.WpD-ssVYFCYEKYplIET+WsVFhRsWKNFLFaDDGPlLlG+K+pQAlhFppsGphpLGp	........YlPLDpYpRKWIFTHtSMPVP-tDLApIKPMsptRAAQhWKENISspSPDAERLSSpDWPtK..sssWst-..ssWhutWES.D.-.spLPEtlssals.WQDDVTVYFCYEKYNVlETKWuVFKRaWKNFLFY.D.DGPhLlGRRRKpALWFsocGpVKhG.........	0	5	12	25
+10996	PF11164	DUF2948		Protein of unknown function (DUF2948)	Pollington J, Finn RD	anon	Pfam-B_002527 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	25.00	25.00	47.70	47.50	23.70	22.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.48	0.71	-4.55	42	207	2009-01-15 18:05:59	2008-08-06 15:56:21	3	2	205	0	71	164	1063	138.90	46	92.73	CHANGED	L+LhAhDs-DLtVISAhlQDAVh.su-hpWctpp+RFuLllNRFcWEss........tptpssERVposLth-sVhsVpSpGlc+sctDt.VLuLLulsFcP....uEssuGplhLshAGsGslRL-VEslEspLpDlotsatusuc..PsH	.........LKLlALDtEDLpVlSAHlQDAVlcluDlpahscc+RFsLshNRFsWEcs.......................hcptshcRhpouLpFscV.ts+upGIs+p.spD.sVLSLLulcF.s....ups.....PuGslpLsFuus..u..AIRL-VEClEspLsDlGssWpstut..PcH..........	0	20	43	51
+10997	PF11165	DUF2949		Protein of unknown function (DUF2949)	Pollington J, Finn RD	anon	Pfam-B_002571 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	22.20	22.20	22.70	24.70	21.90	22.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.68	0.72	-3.79	37	156	2009-09-10 15:59:59	2008-08-06 16:07:02	3	1	70	0	69	147	81	57.80	39	82.18	CHANGED	ssspLlpFLpp-LuLspsulslul+........ptctppuPLPhlLWpYGLloLpQL-plhDWlpp	....h..ppLlpFLpp-LulsssulslAlR........ppp..tp.......us...LPMlLWQYGLloLpQL-plaDWL-.t..	1	10	50	67
+10998	PF11166	DUF2951		Protein of unknown function (DUF2951)	Pollington J, Finn RD	anon	Pfam-B_002585 (release 23.0)	Family	This family of proteins has no known function. It has a highly conserved sequence.	24.90	24.90	25.40	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.39	0.72	-4.14	6	299	2009-01-15 18:05:59	2008-08-06 16:12:50	3	1	192	0	5	56	0	95.60	72	98.34	CHANGED	ht.hpR..hEp-hRIpRLE-NDKphFsoL-cI+cGQ+sQEhVNpKhDhTLDuIpRERELDccsKEcNpKNI+DlKMWlLGLlGTIhuSLlIAlLRTlFGI	......FGFTKR..HEp-WRlpRLEENDKTMFpph-cIc-u.+TQEpl.pKLD+sh-p..lpR-...+E.DEKNKccNsKNIRDlKMWILGLIGTIhSTlVIALLRTlFGI........................	0	4	4	5
+10999	PF11167	DUF2953		Protein of unknown function (DUF2953)	Pollington J, Finn RD	anon	Pfam-B_002617 (release 23.0)	Family	This family of proteins has no known function.	21.70	21.70	22.30	22.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.47	0.72	-4.06	60	397	2009-01-15 18:05:59	2008-08-07 09:14:46	3	1	368	0	104	330	4	50.90	29	23.20	CHANGED	sphGhtDsAhTullhGhlaultuhlhshh........pp.plplpPsFpcphh.cs	.......hphGhsDAAhTGllsGhhaulhuhhhshl.phhph...ptsphplsPsFppphh.t.........	1	45	85	92
+11000	PF11168	DUF2955		Protein of unknown function (DUF2955)	Pollington J, Finn RD	anon	Pfam-B_002614 (release 23.0)	Family	Some members in this family of proteins with unknown function annotate the proteins as membrane protein. However, this cannot be confirmed.	21.90	21.90	21.90	21.90	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.72	0.71	-4.51	42	253	2012-10-02 19:04:43	2008-08-07 10:34:55	3	2	195	0	82	281	23	138.00	25	40.93	CHANGED	+sLRluhGssluhsluhhhuashuhhsslhshhlL.shssshshphhhplhhsslhssh.shllsshlppaPlhhslllulhhhhthhhhhcssthLhushhllsholl.thushs..sssh.sllhulhhuhllulhlshls	...............psLRIuhGssluhslsh.hhshshuhahslhPhhlL.uhssshshcshhphlhssslsslpssllsshhtpaPhlhs.l...llhh..ha..hapat..h..h..scs.shhLFGshs..lls..ho...lhltFu...o...as...ss..shpslhhu.hhusllulhlshlh.......................................	0	7	21	53
+11001	PF11169	DUF2956		Protein of unknown function (DUF2956)	Pollington J, Finn RD	anon	Pfam-B_002632 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	82.50	82.20	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.57	0.72	-4.07	27	155	2009-01-15 18:05:59	2008-08-07 11:07:38	3	1	154	0	34	105	7	105.30	60	91.04	CHANGED	SsETQpEAh+lAKuTQKPGQTKEQTKLIAQGIEKGIApYKKQQKsKuR-tDKt+Kpph+sKpp........sppppspp..hspsp.shLPWs...LLsLSWlGFhuYlhh	....SppTQQEAlKIAKATQ+PGQTKEQTKLIAQGIEKGIA.YKKQQKEKpRQADKhRKKslKAKppsspt.....ts--.s...sph.s.ssspsppupLsWl...LLsLSWlGFluYhh.h.	0	5	13	24
+11002	PF11170	DUF2957		Protein of unknown function (DUF2957)	Pollington J, Finn RD	anon	Pfam-B_002671 (release 23.0)	Family	Some members annotate the proteins to be putative lipoproteins however this cannot be confirmed. Currently no function is known for this family of proteins.	25.00	25.00	36.40	39.30	17.70	17.50	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.21	0.70	-5.83	12	197	2009-01-15 18:05:59	2008-08-07 11:20:59	3	2	60	0	48	160	10	358.20	48	79.41	CHANGED	TaQlpalESsVPposGoVsPTR...sG..hshoGohsp.Ts.LPTsc.NpCAFhLpsuo.........lDsscPshlFlGpGVsGGuIPGATIpFsGl.....lGlGslPspTFPaYPFIuFupTETDhoKlAGsYNtlGaH.lPSt..........satPsssshp.TLNADGS...Csst...ssuoCpsoGssas.+....ususssF.Sssh..tGp.shPohupsts.h......A+GlhIVGKLpstLVPllIRsGYApsssssh.....sssADDEsGIulLuPssAlAssSlpGtYIGssSshsYtsoslsGs......pushLDPh.sspssLsusaphDaoQss.sGslossshsus.sushTGplhFsGusauaL-..osusoP.Fslus	.TaQlpal-SPVPtoTGTVsPTR....AG..ssloGTlspt.Tu..LPTsc.NpCAFhLs..suS...........................ls.scPshlFlG.GVsGGuIPGATIQFsGl..........lslGpVPspoFsaYPFIGFospETDloKlAGsYNpLGYHpVPSt..........Naussulsup.TlNADGo...Cssosh.......suG....uCh....soG....ssas.p....ususssFpSpsh...tsQ....lhPohuphs..h....t.A+GhhIVGKLpsQLVPllIRTGsAN..s..sssssh....sssADDESGISlLuPtsAlAuGS.sGtYhGsDSsFcYpsTulsGu......puThlDPh.sspsuLssuhsLDYsQss.PGslTsspssuo...us..ss...TGphlFoGGlauaLD..ssssss.Folsh................................	0	4	8	22
+11003	PF11171	DUF2958		Protein of unknown function (DUF2958)	Pollington J, Finn RD	anon	Pfam-B_002712 (release 23.0)	Family	Some members are annotated as lipoproteins however this cannot be confirmed. This family of proteins has no known function.	20.30	20.30	20.30	20.30	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.44	0.71	-4.23	21	220	2009-01-15 18:05:59	2008-08-07 11:26:14	3	10	148	0	82	208	67	105.00	36	22.38	CHANGED	LlTsp.RspLLANGptp........pchDPhPVVKLFsPsusuTWLlTELD.tDGD.phFGLsDLGhGhPELGsVSLuELtul+GPhGLslERDLaFpuppsLSsYActActsGuIls	....................................................hs.t.+t.Lhtpstt..tt......thD.hPV.V+hFsP..ussTWLLsEhD..P.t.Ds..........D...tuFGLs..D.l..GhG..h.PELGhhuLsELtul+...s.hs...ls........lcRDlaFp...........sp+.l..a.t.u...t....s........................	1	9	48	70
+11004	PF11172	DUF2959		Protein of unknown function (DUF2959)	Pollington J, Finn RD	anon	Pfam-B_002747 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	31.50	31.50	36.30	36.00	31.10	30.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.31	0.71	-4.56	27	148	2009-01-15 18:05:59	2008-08-07 11:40:00	3	2	143	0	54	137	29	200.00	51	92.68	CHANGED	llhLoG..CQSAYYuAMEKVGlHKRDIhVDRV--A+-oQp-ApEpFpSALEpapullsa-GG-LEctYspLscpYEsSpsuAccVpsRIcpVE-VAcALF-EWppELcpYsssoLRcsSpp+LcpT+ppYppLlpuM++AEsKMpPVLssh+DpVLYLKHNLNApAIuuLpGEhsslps-lspLlp-MppuIsEuspFIpphp	.....................h.hhLoGCQ.S....A...YYuAME+.V.G.hHKRDI..hVDRVE-A+-SQp-AQcpFsSALEphpuLssaDGG-LEssYsplNDcYEsSppAAp-VpsRIsslEDVA-ALF-EWpsELstYosA.oLRRsScpKLccT+ppYppLlpuM++AEsKMsPVLssh+DNsLYLKHNLNApAIuuLpGEFsoLcpDIstLIppMNpuIsESscFIppL..........................	0	16	29	45
+11005	PF11173	DUF2960		Protein of unknown function (DUF2960)	Pollington J, Finn RD	anon	Pfam-B_002756 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	20.60	20.60	21.10	99.90	18.50	20.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.66	0.72	-3.68	20	165	2009-01-15 18:05:59	2008-08-07 11:57:25	3	1	165	0	35	76	9	78.50	62	89.53	CHANGED	MARpItYTaKspsKcIsFSY-caHslaEAVAAAEGIDLTsaLtMEpQlthsS.+uspAV+saRcscFt+hGFocIpal+-	MARTIlYTYKsQ-KsLsFSY-KHHNIaEAVAEAEGIDLT-FLKMEtQlEulS..DTKuVRNFRDNaF+KLGFupITLt....	1	5	12	24
+11006	PF11174	DUF2970		Protein of unknown function (DUF2970)	Mistry J, Coggill P	anon	Pfam-B_713 (release 23.0)	Family	This short family is conserved in Proteobacteria. The function is not known.	20.20	20.20	31.30	31.00	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-8.58	0.72	-4.38	68	334	2009-01-15 18:05:59	2008-08-07 12:00:31	3	1	266	0	122	275	95	55.70	35	81.05	CHANGED	hhpshpuVlhuhhGVpppps+p+Dhsphs...PlhhIlsGllhshlFlhsLlhlVphVl	....hhpsl+uVhhuFFGVp.pscs+ppDhsphs...PltlllsGllhsslFlssLlhlV+hVl...	1	19	56	89
+11007	PF11175	DUF2961		Protein of unknown function (DUF2961)	Pollington J, Finn RD	anon	Pfam-B_002770 (release 23.0)	Family	This family of proteins has no known function.	20.30	20.30	21.60	20.30	18.20	20.20	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.64	0.70	-5.05	37	285	2009-01-15 18:05:59	2008-08-07 12:01:15	3	5	193	0	83	254	31	241.70	34	57.17	CHANGED	hhRp.lllRhYWDspptPoVpsPlGDFFusGau......hsthsShslss..ssssu........hssYa.MPFp+pA+IplpNpsstshtthaaplsY.s.h....ttlsccssYFHApW....+cppsh.......................shspsashl-.lcG+GpYVGshl...ulps.............hpss.....WaG..EG-.+halDG-..phPolpGTGoEDYFsuuWs...........h.hppassPatGhshhppsssh.t.....................hhuhYRaHlhDPIhFpcsL+lTlp...........ctch.p....phpsDhuSsAYW...YQs	......................................................................................................hRc.lll+hYWDspppPoVpsPlGDFFssGau.............................tsphsSlslss.....sPstu..........hNsYa.MPFp+pA+IslpNppspsh..t....ha..apIs....Y..s.h.......plspc......shYFHApW+Rpp.s.....................................phtps.a.sllD...lcG....+GpYVGshl...ulps......................pph........WaG..EG-.+ha..lDG-.....phPolpGTGoEDYFsuuWs...............................hppassPahGhsh...hpppssh.t.....................hhuhYRaHl.DPlhFpcsL+lolp................csph......ptpsDhuSsAYWYp.................................................................	1	33	56	69
+11008	PF11176	DUF2962		Protein of unknown function (DUF2962)	Pollington J, Finn RD	anon	Pfam-B_002773 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	23.30	23.80	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.81	0.71	-4.65	31	261	2009-01-15 18:05:59	2008-08-08 09:11:59	3	6	220	1	177	255	0	150.00	30	79.84	CHANGED	KlpKplu....tthcslHPpSRKsppLsRsshR-cKlpptKttptc+ps..hhp+ltaFpctlpp......................pppsaohp-hpplIc...................palsRp..DsELcplcpc....RRtuRP.ssRpphLcpphctEpc-ac..sGa.lPDLocscslchL+p.W....s.Gshss..lsslKhl+lop	.........................ptht....tpppslHstSR+utpLpRtshRpc+hpch+p.t+t.t+pph.......hh......c.........+ltaFppplss......................pptshotp-hpplIp...................p.alpRh..cpEL-plchc.......+Rp...GR.....ssRcsllcpph-pEpppac..sGh.lPDlssspslchl+p.W.......s.Gshtt..lssl+hh+ls.t..................	1	51	86	131
+11009	PF11177	DUF2964		Protein of unknown function (DUF2964)	Pollington J, Finn RD	anon	Pfam-B_002804 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	20.80	20.80	20.90	21.70	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.97	0.72	-4.04	8	102	2009-01-15 18:05:59	2008-08-08 10:27:27	3	1	52	0	27	87	3	59.70	48	91.07	CHANGED	MlRtchRlVLATlAVFIALAGlssslHGlLFD.ssshhYGlluLllGlAuFVlhLNPsPsDc	......MlR.phRlVLAsIAlFlsLAGhhsAl+GLLFDtsssltYGshAlslGVssFVlhLNstspD......	2	2	4	9
+11010	PF11178	DUF2963		Protein of unknown function (DUF2963)	Pollington J, Finn RD	anon	Pfam-B_002790 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Mollicutes.	21.70	21.70	22.40	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.96	0.72	-4.54	42	215	2009-01-15 18:05:59	2008-08-08 10:44:50	3	8	18	0	139	213	4	48.20	33	56.38	CHANGED	Yp..DGc.pIphI..p....EYsspTGphIKcThY.p.DGcsIphIp..EYs..pssphIKpT............h	...............................a..cGp..pIphI..p........Eassp.TuchIKpThY.p.D.G.p.sIp.Ip..-as...ptp.h.p.....................	0	33	35	98
+11011	PF11179	DUF2967		Protein of unknown function (DUF2967)	Pollington J, Finn RD	anon	Pfam-B_002838 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Drosophila.	25.00	25.00	37.20	37.20	21.70	21.10	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.88	0.70	-4.89	2	40	2009-01-15 18:05:59	2008-08-08 11:05:57	3	2	15	0	8	40	0	242.90	79	53.62	CHANGED	PSTAPPPTRhREHFTFDPPQSPKSARoSEKupSHFoFK....EsAppAthuSsphhuuG...................AAoEusEtp-ER...uluNRsKKLRsRERDs...................N+ISPSVSPSpSpRsSPKRE++RTTP.sSTGAIuKlsSAPPTMKDuNFFGSStpQKQR.SQp.Ps...pQLSPSS....QQRKYSSSSSSGSS-RCLR-sTusGTMFPFDREALDYERIQRECFAPSSsTASsSSDS.EAENCSVYERK.uADIFQ	...................PSTAPPP.TRGREHFTFDPPQSPKSARTSEKARSHFTFK..........EDAQQARRASNSYY.AGG..........................................AAoEAAE.AQEER......AVANRNKKLRARERDSMAGNANANANANGGS.NSoRNRISPSVSP..SSSNRTSPKRERKRTT....PSVSTGAIAKINSAPPTMKDGNFFGSSQNQK.QRPS.QQ.QPSPQQQQLSPSSQA.AAQQRKYSSSSSSGSS-RCLRD.V...A.AAGTMFPFDREALDYERIQRECFAPSSA.TASTSSDSDEAENCSVYERKLSADIFQ...............	0	1	2	5
+11012	PF11180	DUF2968		Protein of unknown function (DUF2968)	Pollington J, Finn RD	anon	Pfam-B_002850 (release 23.0)	Family	This family of proteins has no known function.	27.00	27.00	27.40	79.90	25.60	25.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.24	0.71	-4.92	12	142	2009-09-11 05:56:16	2008-08-08 11:12:26	3	1	95	0	44	135	4	192.10	43	81.57	CHANGED	pPsst.......sstsssss.ssAsutuu.....spusVsELpphlpsppLoELRTTYNGuYGASLLFpsc-hTYYVALFQpKsFWRVIKTsshspAEtlY+sFucQospLA-lElRRspLpAQKA.hER.lAhupsRAppLQADlpltppQcttVsscQpQsRpEsssLptp+ppspsQLcphQRQlctLQtptpp...ulP	.....................s..........t.ssssss..ssAsusus.........upusVsELQphlpu+cLoEhRTTYNGoYGASLLFssp-hTYYVALFQpKsFWRVIKTtscs+AEtlYcsFucQotpLAssElc+scLEuQKAhh-RtIAhsppRAppLQADLslsRpQpAtVusRQcsspsEssALpsp+pttQsQLRpLQpQlRpLQ+Qsps......s...........	0	4	14	28
+11013	PF11181	YflT		Heat induced stress protein YflT	Pollington J, Finn RD	anon	PRODOM	Family	YflT is a heat induced protein.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.90	0.72	-3.87	12	479	2009-01-15 18:05:59	2008-08-08 11:33:15	3	3	229	0	85	298	1	95.40	28	57.40	CHANGED	.hlctapNppclhpslppLptpGhspcDIYVluHDc-Roccls-sT.....csssluhcE.pGhhsslhshFp.cpGDELRs+hpclGlocsEAcpaEccLDcGKlllhV	.......hVt.apscpEshpslpcLpp..cGhppc-I.hVlo.+....-...c.......cch........-cl.t.-so................ssN.....s.h.sscc...pulhsphhshF......p........tpt...D...p.....c.sth.....pp....hs..hscpEhp.YcpclppG.+hllh.......................	0	28	65	76
+11014	PF11182	AlgF		Alginate O-acetyl transferase AlgF 	Pollington J, Finn RD	anon	PRODOM	Family	AlgF is essential for the addition of O-acetyl groups to alginate, an extracellular polysaccharide. The presence of O-acetyl groups plays an important role in the ability of the polymer to act as a virulence factor [1].	25.40	25.40	25.40	26.20	24.60	25.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.81	0.71	-4.60	13	100	2009-01-15 18:05:59	2008-08-08 11:43:13	3	5	83	0	31	89	3	173.80	41	71.82	CHANGED	slhLuluuhsAtA..u-ssLYsssAPpsSAFVRhhNuosuplslsl.GssshpslusspsusahahssGuts.....hplGupslsscl..suspahTlVspssu.....pshLlE-PshpscpKA.LthhNLoss..ssoL+TADGcs-VVcsVussupucRpINPVKlsLAlhsusppVushcsl.sLc+G-sho	.............u.huLulhuht....A.A..u-...uALYussAPcGSsFVRhhNAusup..lss.o..V.GssslppVushu.uosa..pFhPtGsYo.......splGups..l.PVcL...ss-cYYTlVspsuG......pspLlE-.P.s.FcN+pKuLlRV.NLosp..pLoLKTADGKT-VVcsVuspupGcR-I.NPVKVsLALasGs+KV..ucl+.sV.sLcRGEsh................................	0	4	12	24
+11015	PF11183	PmrD		Polymyxin resistance protein PmrD	Pollington J, Finn RD	anon	PRODOM	Family	PmrB forms a two-component system (TCS) with PmrA that allows Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin G [1]. The TCS is linked to another one via the polymyxin resistance protein PmrD. PmrD is the first protein identified to mediate the connectivity between the two TCSs.  It binds to the N terminal domain of the PmrA response regulator which prevents its dephosphorylation, thereby promoting the the transcription of genes involved in polymyxin resistance [2].	21.00	21.00	22.10	27.10	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.93	0.72	-4.17	3	441	2009-09-10 18:00:43	2008-08-08 11:46:37	3	1	427	2	10	87	0	79.60	76	92.99	CHANGED	MEWLVKKSpsNKpcu.CHVllLCDuGGALKMIAElcS.cltL+sGDlLSPLpDApYCINREKpQTLKIlsAoCYSsDEWpRtsK	MEW..LVKKSppsKpcs.pHVLMLCDAGGAIKMIAEVKS.DFAVKVGDLLSPLQNALYCINREKLHTVKVLSASsYSPDEWERQC+....	0	1	3	5
+11016	PF11184	DUF2969		Protein of unknown function (DUF2969)	Pollington J, Finn RD	anon	Pfam-B_002861 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Lactobacillales.	25.00	25.00	29.40	28.90	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.39	0.72	-3.89	19	584	2009-01-15 18:05:59	2008-08-08 11:53:44	3	2	582	0	56	191	0	74.00	46	97.69	CHANGED	MSKK-KcIElplp-tcs....ss.sshplhI.GK+hIGpItph.-pcF..sshpssssphhhKsh-pAlptllcpaNLp	....MS.KK-KcIEIplsDsKsplstcsh-ua..pLhI.GKKlIGEIs-l..DspF..AIlpsuss-uFaKpLEcAlEhlIcsYNLp........	0	10	25	40
+11017	PF11185	DUF2971		Protein of unknown function (DUF2971)	Pollington J, Finn RD	anon	Pfam-B_002776 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.80	21.80	21.80	21.80	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.31	0.72	-3.27	145	706	2009-01-15 18:05:59	2008-08-08 12:00:33	3	24	537	0	185	600	22	90.70	22	28.45	CHANGED	MWspYuss.t.....pGlslta.....................................................tttt............thhhtpVpYsspp..tht.hphhttt....................................................pthhhh.......KppsapaEpEhRl	........................hWu.tYuss.p..........pGhslta..........................................................................t..pt........................tthhh..t..p..V..p..Ypsp....pht..hhph.h..t..........................................................................................h.pthhhhKspsWpaEpEhRl................	0	76	122	149
+11018	PF11186	DUF2972		Protein of unknown function (DUF2972)	Pollington J, Finn RD	anon	Pfam-B_002895 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as sugar transferase proteins, however this cannot be confirmed.	21.90	21.90	23.40	23.30	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.51	0.71	-4.42	21	237	2009-01-15 18:05:59	2008-08-08 13:53:51	3	1	88	0	9	179	0	178.40	36	43.56	CHANGED	alDhpEIhsc+sFpThppLucta..pFs.Pp..s-cphappth.huch.hslLPlsLhlp................sshslhh...........s.h.h.......................hhphpcphhsIspplh....pps.hh-pl.......hlhlcpp-achlhp...spplhpplKpYLpcF...l.tLccplchccs+hlpEcDlLpYL..Kcp+plph+hKplLDcE.LsaIKppRPDIVsSWKYYQEFE+hCcELc	..YlDhp-IptppAapThphLuhpa..sFs.P....pp.phFp.p....hs.l..hhlh..PlpLhhsp................phpI.h...........p.l.l..s....................h.phppp.hlcIh.pplh.....pp.hhssh..hlhIcppcap.Lpp...sphLhppl+pYl.cF...l.tlcppls.pcpphh+EcDlLsYh..pcspslhhphppIh-pE.LpalKpp+PcIlsSWcYYpEFEchhpt....................	0	3	8	9
+11019	PF11187	DUF2974		Protein of unknown function (DUF2974)	Pollington J, Finn RD	anon	Pfam-B_002933 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.36	0.70	-4.98	24	1013	2012-10-03 11:45:05	2008-08-08 14:07:40	3	19	778	0	142	1032	52	195.30	27	47.94	CHANGED	hupSsRFpslcltsalsplstc..ppQFuAhsapls..........ssohhluFRGTDsollGWKEDFpMuap..lsAQctAhcYLpplhpphss........s.lhLsGHSKGGNLAhYAAhp.hpsslp.......................pRItclYoaDuPGh.cphhp..sstapplts+lpchlPpsSllGhhLEpspph....hlVpSss..ulhQHcsaoWpl.psspFlpt.cslsssSphhppslppWlsslst-pRcthh-sLFs	................................................................................h.....Ratthph.thhp.th.....p........p......tp...Q.Fu.A..h.s.a.pls........................s.s.h.hl.s.FRG.....T.D........s........o.....l...l......G.............W.....+..E.....D.h.....p...h.....s......a.h..t......p......h...s..u......Q........c.......p..A......h.....p.Y..L..c.p...h.h.t.p.a....ss...........................................p.lhlsGHSKGGNL.A.h.YAAsp....hp.tp.h.p...............................p.p..I..t....t.lasa........Du.P....Gh...p..p..h..hp.......p...t....h..p..t..h...h..t+.h.h.hl.Pp.tul.lGhhhp....t..............hl...V..p..S.....p......hh.....Q....H..hp.Wph....t......ttph..........t..s.....u...htt..h.th.tths.tpht.hht.ha.t.......................................................................................................................................................	0	35	74	101
+11020	PF11188	DUF2975		Protein of unknown function (DUF2975)	Pollington J, Finn RD, Bateman A	anon	Pfam-B_2875 & Pfam-B_3379 (release 23.0) & JH:B0MX27	Family	This family of bacterial proteins have no known function. These proteins are likely to be integral membrane proteins. The proteins contain a highly conserved glutamic acid close to their C-terminus.	26.10	26.10	26.10	26.10	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.65	0.71	-4.45	99	988	2009-01-15 18:05:59	2008-08-08 14:12:43	3	1	759	0	233	831	18	140.00	17	82.57	CHANGED	hhhsthhtth...........sphhsthshhhhshh.................................lh...shhsslshhhulhphh+Llpplpcs.psFot..pslctL+hIshshlshsllhhhshhhhhhh.st..t..................hhhhhhshsshhlu.llhhllpclhtpAl.......cl+pEpDLTI	...................................................................................................h................................h.hh....................................lh.....hhhssls...h...h..h...slh....ph.h+....Ll..ph.l..pc.......s..psFop..tslptl+plths..hl...s...hu....ll....h.h....lh....h....sh.h..h.hh.....ht........s...h................hhhhsh.h.s.shllu.lhh..hllp.c.lhppAl.......clcpEsDhTl......................	0	90	171	199
+11021	PF11189	DUF2973		Protein of unknown function (DUF2973)	Pollington J, Finn RD	anon	Pfam-B_002929 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently they have no known function.	22.20	22.20	22.30	30.30	20.10	21.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.18	0.72	-4.20	34	106	2009-01-15 18:05:59	2008-08-08 14:16:03	3	1	95	0	32	106	363	66.70	34	72.64	CHANGED	hhsLlYhhsFhhLhh.AapshhpGhhsssht...............p.p.tt......................s+ssphTsHPELLDpsGclscE-LLsVR	...........................hh.LlYhhAFsllhhlAhtshh+uhhsssht...............ppp..s......................sppsphssHPELLDcsGpllpEsLLslR.	0	4	18	29
+11022	PF11190	DUF2976		Protein of unknown function (DUF2976)	Pollington J, Finn RD	anon	Pfam-B_002963 (release 23.0)	Family	This family of proteins has no known function. Some members are annotated as membrane proteins however this cannot be confirmed.	26.10	26.10	29.80	40.90	25.30	25.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.89	0.72	-4.46	22	218	2009-01-15 18:05:59	2008-08-08 14:22:53	3	1	179	0	63	180	9	86.90	41	72.80	CHANGED	LPshpsPosG.......sGsshhpplpsYhhDGhhLlGLlluAhuFlsVuhsulpsasEl+s..GKtsWucFGshllVGllLllhslaLlscAssI	......LPshEsPopG.......sGsGlhpTlpsYuhDhlhLluLllsAsuFlsVuhpuluoYsEl+s..G+tsWupFGhslsVGslLlllsIWLlTcAssI......	0	6	27	50
+11023	PF11191	DUF2782		Protein of unknown function (DUF2782)	Gunasekaran P, Mistry J	anon	Pfam-B_001700 (release 23.0)	Family	This is a bacterial family of proteins whose function is unknown.	21.20	21.20	21.60	21.60	20.80	21.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.61	0.72	-4.06	41	297	2009-01-15 18:05:59	2008-08-08 14:24:31	3	2	290	0	102	233	41	111.00	24	91.26	CHANGED	p....llhss....hLussshAtsst.pss........ss..................p.-P.............-lsI..hpcss.pplpEYRlsGplhhlKVpPcsG...hsYaLlcs-Gp.upascpst....s.shhsPtW.............................plapW	..........................................................................h.....h....hhsh.s...usss......ps.s............s..................................cs..................-hhl......hp-ss..splpEYRlsGphaslcVpPtpG....tsYallcssus.ssascppt.....schhhstW...............................plapW...........................	1	20	64	87
+11024	PF11192	DUF2977		Protein of unknown function (DUF2977)	Pollington J, Finn RD	anon	Pfam-B_002980 (release 23.0)	Family	This family of proteins has no known function.	20.60	20.60	20.80	25.10	19.50	17.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.05	0.72	-4.14	7	236	2009-01-15 18:05:59	2008-08-08 14:27:35	3	2	170	0	4	81	0	61.20	58	49.41	CHANGED	MplhlN...........D+stIhGasshGuh-pu...l-lc.splPtpFpcpFcPctahh.su..pIlhNpsYhc.p.	.........MpIhVN...........c+NElIuYs.hGGhcpu...lDl-...NlP.pFpp.FcP+tFhaoNG......EIhaNpsapcEc.s.....	1	4	4	4
+11025	PF11193	DUF2812		Protein of unknown function (DUF2812)	Gunasekaran P, Mistry J	anon	Pfam-B_001697 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins, however some members of this family are annotated as membrane proteins.	22.10	22.10	22.20	22.30	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.43	0.71	-3.94	34	805	2009-01-15 18:05:59	2008-08-08 14:30:02	3	2	587	0	77	554	3	113.20	26	57.20	CHANGED	hsh-+.-EpaLpcMupcGatLpchshhh......YpFc+.scPpchhYclDap.........sppcpp-Yhphac-sGWchl.....sph..sphp.......................aFpcttsptt.....-IaoDppo+hpphpp.hhphhhhhhhhhl	............h.sh-+-EpaLccMth+GWphpp..h.phhh.........apFcp.sp.Pccs...h..Y+l-hp............p.ppchpcYhphac-pGWchl.......s.h....ushp................................ha+K....psssh......plao..-.pts+....hphh+p..hhp.h.hhhhhh...h.................................	0	35	59	69
+11027	PF11195	DUF2829		Protein of unknown function (DUF2829) 	Gunasekaran P, Mistry J	anon	Pfam-B_001848 (release 23.0)	Family	This is a uncharacterised family of proteins found in bacteria and bacteriphages.	25.00	25.00	25.10	27.30	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.81	0.72	-3.50	24	638	2009-09-11 11:01:00	2008-08-08 14:31:38	3	2	599	0	49	240	8	75.90	53	85.74	CHANGED	MsFpEAl..tlKpGcKhsRp.GWsGtphaltl...........................psssh..psalhlpss....psph....hs.WsPossDlLA-DWhlV	.............MTFEEILP.uL.KAt+KhVRs.GWuGsEpYVpL................................................hDsl.ctsGhsLp.hTPYFLIsso.........cGEG....FSMWuPTsCDVLAsDWl.V..	0	13	27	37
+11028	PF11196	DUF2834		Protein of unknown function (DUF2834)	Gunasekaran P, Mistry J	anon	Pfam-B_001850 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.90	21.90	22.50	23.10	21.70	21.60	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.33	0.72	-3.83	47	198	2009-01-15 18:05:59	2008-08-08 14:32:12	3	1	185	0	55	167	264	99.00	30	76.31	CHANGED	lYLhLAlhGslhPhht.ltal..tpsG.......h-ltshlss.hhuN.suupulshDLhluAlslslallsEu.+hph+thah...slhsohslulusGhPLaLaLRp+p	............................lYhllulhuh.slsahhslpal...pp.u............hshst.alph..hhsN.sAusu...huhDlhIuslslh.lahhs-uhR..hsl.+phWl.....hhluohhluhuhuhPhYLhhRER.....	0	14	32	46
+11029	PF11197	DUF2835		Protein of unknown function (DUF2835)	Gunasekaran P, Mistry J	anon	Pfam-B_001851 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins. One member of this family (Swiss:A4VM42) is annotated as the A subunit of Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV).	25.00	25.00	56.50	56.40	21.60	19.00	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-8.89	0.72	-4.20	42	218	2009-01-15 18:05:59	2008-08-08 14:34:21	3	1	218	0	59	150	18	64.60	43	91.10	CHANGED	hhFslslShpcals.aYpGtAppV.VhspsGcplplPApphRPFlTppGl+GpFclphspps+alsLp+	......hhhplslShpphls.aYpGhAspVhVpocpGh+lpLPAp+LRPFLop.GV+GpFRLshDpss+FlpLE...	0	15	31	47
+11030	PF11198	DUF2857		Protein of unknown function (DUF2857)	Gunasekaran P, Mistry J	anon	Pfam-B_001886 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	31.00	31.00	32.70	38.20	30.70	30.50	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.00	0.71	-4.76	32	266	2009-01-15 18:05:59	2008-08-08 14:35:22	3	2	219	0	73	222	8	177.30	33	90.10	CHANGED	sLNpAlLsphlpsL+pGp.lppCcshGhs.--lptLpphshpcl..LssusVshss....lslsp-sht+llppsccppp....cpphl-RhLcLGAShpMhppaFGL.ospEVutRRclL.ulstppGRhshhsE.ppcptlWctWpt..pptslt.h-ssphL-hhMhlAEphsl.............sLoslWshlppW.pps	........................lNpulLsphLhsL+sGp.l++CcshGhs.-ElshLppholpcl..Lu.susVshss....lsls+-sLp+lLspuccppp....c.ppl-RALcLGAShphhpca.FGL.ospEVutRRcll.Gls...h...+.pG.RpsshsE.-p-stlWcpWp.....ctslpt.DssphL-hhM.lAE....phsl.............sLosVWstlppW.pps......................	0	7	33	54
+11031	PF11199	DUF2891		Protein of unknown function (DUF2891)	Gunasekaran P, Mistry J	anon	Pfam-B_001921 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	45.90	45.60	22.40	21.90	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.14	0.70	-5.85	33	328	2009-01-15 18:05:59	2008-08-08 14:37:19	3	1	324	0	81	223	116	319.90	46	94.86	CHANGED	As+FApLsLssls+EYPNKlsHshsussDlp.sP+pLHPsFYGsaDWHSuVHGaWhLV+LL+pa...P-hspsspIpusl-cplTsEslAsElAYhppststu.FERPYGWAWLLpLstELppac.........sstupcWupsLpPLsphlspRhpsaLP+LsYPlRlGsHsNTAFALuLAhDaAcsstcpsLpphItppupcaahpDpssPstaEPuGcDFLSPsLtEAcLMRRVLs....sspFspWhctFLPplsstt.sphlpPusVoDRoDGKluHLDGLNLSRAWshculAsuLPps..ttstlpssApcHlsuulsplsut.cYhGsHWLuSFAlhA	......................ppaAplsLsslpREaPN+hsHphsussDlp.sP+tLHPhFYGsaDWHSSVHuaWhlV+LL+pa.....schspt..-pIhssLcsphTcEsstsEhtYLph....t..p.+........GFERPYGWuWhLtLuspls.hs..........stuppWApslpsluphhhcphhpaLP..KhoYPlRsGTH.NTAFALuLsLDaARt...hp...csp.lttsIlppA++aahsDts...h.u.........aEPuGs....-FLSPuLhEAcLMpRVls....ss-FssWhcsFLPpLspp-.s.sLhsPs....pV.....o..D+..oDGK...l.....A.HLDGLNLSR.AWsh+uLAshLsEs..t+.ttlcpAAscHlspulsplss..DYhGsHWLuSFALhA.........	0	24	50	66
+11032	PF11200	DUF2981		Protein of unknown function (DUF2981)	Pollington J, Finn RD	anon	Pfam-B_003040 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.00	21.00	23.30	23.20	20.20	18.50	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.15	0.70	-5.35	2	8	2009-01-15 18:05:59	2008-08-08 14:59:40	3	2	5	0	8	8	0	120.40	34	56.25	CHANGED	YLILFsFSLVVVSMVALDMAElVHFFPKAPELHshoLLGhTuPFVTRFKsPNASVLFPFNFFKLPNDTTGVLPQL.H...............................DphVVTKFThoplDpHsHKHCNKhsot....RFDDDlSuVLDNhDssDDLpsLRNALKQRLtspN.......TstssoGssD...NYNAYDNPDGKV.uuKDlNS.................spsSsNsssSsspKpptsDSFYDHLPFMPHPGETEGESEEVSKDEFPPETNDLTPEGKSEVVVLYKLQKRs.phhhS.....alhhhlY	................................................................................................................t...........................................................................................................................................................................................................................................................Y-clPFhPH.spTEGEoEElStsEhPPEspsLT.pt.pEVsslhKhQKR............................	0	4	6	7
+11033	PF11201	DUF2982		Protein of unknown function (DUF2982)	Pollington J, Finn RD	anon	Pfam-B_003059 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	25.70	38.90	19.50	17.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.78	0.71	-4.86	24	166	2009-01-15 18:05:59	2008-08-08 15:05:09	3	2	160	0	37	120	8	148.40	48	67.74	CHANGED	SlpLotptlpYaH+pGsWhlcWpNIpRlsls+hppshpphpLPaIGIKLKphsshLssIsPRLAotLLhEQRsLLhhusppcp.shpshEshLhs-tsalsspGppY+GllAMaupRhphLpchLGYclalstssLDRsspEFluLLRcaptts	.......................s.aTLTsoHlQ.HahpGGWVl+WsNIppIGlsphc.p-GWaQPLPWlGI+LKcYsPaLsuIsPRLuTpLLlpQRuLLhLuApQps..c...tpp.......aEDhllDspsYls.scGcpYpGL.AMLANRMpYpRcahGYDlFISpp-LDRsu-EFVGLhRRYLAAA.........	0	6	14	27
+11034	PF11202	PRTase_1	DUF2983;	Phosphoribosyl transferase (PRTase)	Anantharaman V, Pollington J, Finn RD	anon	Anantharaman V	Family	This PRTase family has a C terminal RNA binding Pelota domain [1]. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	31.70	31.70	37.40	37.30	26.20	25.20	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.58	0.70	-5.41	68	350	2012-10-10 14:25:38	2008-08-08 15:38:30	3	7	335	0	73	275	5	247.50	50	60.57	CHANGED	sl...p...........GSYtssDVpFLL+sl.s..hpp.sss--+EchIQSG.phHYSEMLshEhpPoptYhcLFcpALppsutRlAtsVuhlActlhp......c.ps.ssllLVSLARAGTPlGlLl+Rhlpp........Ghs.....ssHYuISIIRDRGIDpsALcaI..hp+Hs.spslVFVDGWTGKGAIopELpcAl.t.p.h.ppth.............s.......hss.cLsVLADPutCutlhuTc-DaLIPSuhLNuTVSGLlSRTVLssch.l.....ssssF...HGshaYccLtstDlSphFlDslssth	............................h..GSYtPsDVpFLLKsl.s..hp.sssEc+EclIQSGptHYS-MLs.E.tPoptahcLFccALcpsupRlAptVstLAptlhp.......c.ts...p..slVLVSLsRAGsPlGVLl++hl+t.........Ghs...s.HYuISIIRDRGIDtsALcaI..hp..+..H..s..spsIVFVDGWTGKGAIotELtcAL.phpsth.........................s.....hpscLsVLADPsuCuhLhuoc-DaLIPSuhLsusVSGLlSRoVhss-hl..........tthHGshhaccLpphDsSphalDsVsph.h...........	0	20	44	61
+11035	PF11203	DUF2984		Protein of unknown function (DUF2984)	Pollington J, Finn RD	anon	Pfam-B_003006 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed.	21.30	21.30	21.30	21.40	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.14	0.72	-3.89	22	356	2009-09-11 11:43:42	2008-08-08 15:46:26	3	2	151	0	77	242	0	95.90	31	21.98	CHANGED	PAsupRpTWlsLRhcsppshtAlptR..............sts..ultpslssuspRlAspLtspGhsApshpusEhspssstlstt....................................+EsWcthcstsu.assuYtls	............ssupRcTWlsLRhs.spcs..htAlptR.............................sts.hultcshhsuupRlAscLcspGhcAps.s.sus-l.schssshu..s..........................................................cEpW+sl+.ttsu.ahsuYth........................................	1	18	50	70
+11036	PF11204	DUF2985		Protein of unknown function (DUF2985)	Pollington J, Finn RD	anon	Pfam-B_003090 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.00	20.00	21.00	27.60	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.85	0.72	-4.23	20	240	2009-01-15 18:05:59	2008-08-08 16:59:53	3	12	109	0	186	235	0	78.80	38	14.21	CHANGED	h+alpTPhGFhlTlYuh.lshWGuhlhLhLlshlsh........ssup+chWIElssQILNALFslsGhGLAPaRh+DhYahlhht	..................h.palppPhGhhlslYuhhlssaGuhlhLlLhGhls.h................ssup+phWlElssQlLNALFslhuhGlt.PaRhhDhahhhph.............	1	43	96	150
+11037	PF11205	DUF2987		Protein of unknown function (DUF2987)	Pollington J, Finn RD	anon	Pfam-B_003120 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	25.30	25.30	20.30	24.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.78	0.71	-4.54	25	171	2009-01-15 18:05:59	2008-08-08 17:07:43	3	1	169	0	42	124	3	144.00	43	67.67	CHANGED	stAps.lslpYssFYs+LKpssKtsaphVcluFhlscsps.t..CpIpsuplssEccptsLslosspcL.hlPhDcsL+ss+ALlsls.s..spuppCsluhQVhAKp.....hptphotscLtplhspMcshLschuGhhs+....aFtPclsGlshcFs	..............................................App.hhhoYScLaophKsNs.KEsHsDV+huhaFsDspopp..CsIcKAaMEKE.-HYEpLslssupEL.hlPlDssL+pANPLVhVs.o..sp-ccCDhSMhVhAKcs....hpuclohpclpsLlsQMpshL-pLGGMFuu....aFsPsVpGVTlEFs............	0	6	16	29
+11039	PF11207	DUF2989		Protein of unknown function (DUF2989)	Pollington J, 	anon	Pfam-B_003139 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as lipoproteins however this cannot be confirmed.	20.90	20.90	20.90	54.50	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.47	0.71	-4.87	26	162	2009-09-10 14:55:00	2008-08-12 09:52:50	3	1	160	0	37	114	8	199.60	47	74.36	CHANGED	hLsGCtp..stsssplCcssPpL.CsDLs.cDuaCRhcRs-LIhpRaplpc..sPospppYppLphlEsYpKClELAutIpaIppp-+pscRhcAhhpShpplpcLpppT+sSp-PtllYY+WophsDpsAhpphLthEspspl.pssElQhuLAoYYh+pDspKshpLLh+sLpLhpts................phN....................s-llpuLAolappppshcpAYlWuhl	.....LsGChE..pcsT-plCtsNPpL.CppLN.cDGQCRl.RT-LIW+RF-lhK..sPoDcpplcEhphlpsYcKCLELASQ.IQsIcpochKpsRhsALlpSscE.cRlst-L+pSpsPpsLYahWSQhGDpsAp+tFLplEGpscL.cT.AEMQaALATaYo.sRDp.KTlpLLp+sLcLsstp................slN....................s-lLcuLAShapthpch-cAYlWAhl......	0	6	13	25
+11040	PF11208	DUF2992		Protein of unknown function (DUF2992)	Pollington J, Finn RD	anon	Pfam-B_003142 (release 23.0)	Family	This bacterial family of proteins has no known function. However, the cis-regulatory yjdF motif, just upstream from the gene encoding the proteins for this family, is a small non-coding RNA, Rfam:RF01764. The yjdF motif is found in many Firmicutes, including Bacillus subtilis. In most cases, it resides in potential 5' UTRs of homologues of the yjdF gene whose function is unknown. However, in Streptococcus thermophilus, a yjdF RNA motif is associated with an operon whose protein products synthesise nicotinamide adenine dinucleotide (NAD+). Also, the S. thermophilus yjdF RNA lacks typical yjdF motif consensus features downstream of and including the P4 stem. Thus, if yjdF RNAs are riboswitch aptamers, the S. thermophilus RNAs might sense a distinct compound that structurally resembles the ligand bound by other yjdF RNAs. On the ohter hand, perhaps these RNAs have an alternative solution forming a similar binding site, as is observed with some SAM riboswitches [1].	23.80	23.80	27.80	27.60	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.82	0.71	-4.25	29	465	2009-01-15 18:05:59	2008-08-12 10:41:15	3	3	432	0	61	366	9	127.70	37	93.45	CHANGED	LTlaFDs.FWlGlhEphp.sschcls+lsFG.sEPpD.ElhcFlhpch.s.Lphspshtsph......pp++hNPKRhQRpsp...Kchcp.tsluTKAQpAlKhphEppKpc+KptsKpcKcptpcp+aplKppK++pKH+GH	..........LTVaa-s..tFalGlhEpp.c...p..........s.......p..........hpss+hsFG.sEPpDtElhcFlppp.h......hp.Lpassthtsph...........pp+phNPKRlQ..RpstKp..hpp....tthu.TKAQpAl+hphEtpKpc+Khpp+pc+-tp+p++htlKppK.t+pKH+GH.................	0	24	41	48
+11041	PF11209	DUF2993		Protein of unknown function (DUF2993)	Pollington J, Finn RD	anon	Pfam-B_003144 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	27.30	27.30	27.40	27.40	27.00	27.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.45	0.70	-4.44	148	794	2009-09-11 14:20:34	2008-08-12 10:49:44	3	4	452	0	220	612	29	216.40	16	79.06	CHANGED	sssts...................hsthhpptlsptl.psph..ph........spss.pVplsuhP.h..pllpGcls.............plplsspsshh.....sht.....ht...phplpsps.lplshsth...........h.st..hphhp.....sspssspltlstsslsptlss..t.........hpth...................................hspsplplsu.....................................lshpsph......pl......tpt.............h.lphsshp.ht.s........h..............hsthhpths..h..sht...t..........hshsl.plp..plp.lpssslplps.p	..........................................h....shthhscptlsppl.ppts.......t..........ssss..pVslt.s.hP.hlh.plh...sGcls.............plslpstssph.....sht.......ht...........phphshcs.lclshssh..........h........phhp......ssplsusstlst.splschlst.........t...........htth..........................................sts.s.plpltu....................................h.lslpssh..............pl...............ssst.............thhlphssss.huhst.....................h.......................................................................................hpslhpshs.tph.....shtp.............hshsl.phs..slp.sssssl.hph...............................................................................................................................	0	56	159	205
+11042	PF11210	DUF2996		Protein of unknown function (DUF2996)	Pollington J, Finn RD	anon	Pfam-B_003176 (release 23.0)	Family	This family of proteins has no known function.	21.90	21.90	23.60	28.90	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.57	0.71	-3.83	21	102	2009-09-11 16:37:34	2008-08-12 14:04:55	3	1	88	0	45	104	110	115.30	41	66.98	CHANGED	tlE-KPFsEFlppchlPuLppuLpsc.GlsshsLshtcsphPlsG....spCWhVhGchsts....RpFWLsFspcsIsusKshuLA-sGscPShlESFLIDE++lTLsLLlsRllQRLNGQKWLGs	.....hEcKPFsEFhppchlPuLppuLppp.GlsslcLsFpcs.hsh.h....t.h.plpGsa.pst...+pFhlaFsptsIpG..KuFohussGspPSTlEsFL.IDE+...+lTLcLlVhhllQRLNGQKWLs.h................	0	7	30	41
+11043	PF11211	DUF2997		Protein of unknown function (DUF2997)	Pollington J, Finn RD	anon	Pfam-B_003181 (release 23.0)	Family	This family of proteins has no known function.	20.80	20.80	21.90	21.30	20.60	18.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-7.91	0.72	-4.58	41	147	2009-01-15 18:05:59	2008-08-12 14:10:29	3	1	124	0	60	136	151	48.10	38	65.72	CHANGED	lcapIpsDGpVcEpVpGlpGpuCpchTctlEssLGsVp.pcchTuEaat	...........lcahItsDGcVptpVpGltGpuCpchTptl.EstLGsVh..spchTsEaa..........	0	22	47	58
+11044	PF11212	DUF2999		Protein of unknown function (DUF2999)	Pollington J, Finn RD	anon	Pfam-B_003194 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	26.70	134.00	22.90	20.20	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.78	0.72	-3.94	10	145	2009-01-15 18:05:59	2008-08-12 14:26:43	3	1	145	0	26	66	7	81.80	78	97.98	CHANGED	MNPIIAlLKEHNVSDEQIsELFQsLT-NPhhAMAhIsQLGIPsEKLQtLMulVMsNPuLIKEAVEELGLDFuKVEAAKA+Lp	MNPILAhLKENNISsEQINELFQTLTQNPLAAMATluQLGLPQDKLQhLhAQVMQNPALIKpAVEELGLDFuKVEAAKAKLQ.	0	3	7	17
+11045	PF11213	DUF3006		Protein of unknown function (DUF3006)	Pollington J, Finn RD	anon	Pfam-B_003197 (release 23.0)	Family	This family of proteins has no known function.	21.50	21.50	21.50	21.50	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.21	0.72	-4.22	42	334	2009-01-15 18:05:59	2008-08-12 14:37:12	3	2	303	0	107	256	3	68.80	33	87.57	CHANGED	psllDRF.E....schAVlEhpscp.....hsls+shLPtsu+EGD.VLpl...........plplD.cpTcpt+...cclpchhccLhc	..........+sIlDRh.E.....sphAVlchcspp.......hsls+spLPp.ss+.E.GD.Vlhl......................ptsphplDtp-T-cc+...ccIpchhccLh...........................	0	52	85	101
+11046	PF11214	Med2		Mediator complex subunit 2	Wood V, Coggill P	anon	Wood V	Family	This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression [2].	21.10	21.10	21.50	22.00	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.42	0.72	-4.00	10	58	2009-01-15 18:05:59	2008-08-12 14:40:30	3	1	35	0	39	58	0	122.50	45	41.27	CHANGED	M.........................shcsKLssshDDIL+sSu.lh..p.l+sschpSsllTGhNspL.....ppsLsc+IspFauILD-s.spLNcocahl....Dslhp.+pcpc................EhK...EEEE+p++...........E-EE+K	..............NLps+Lp...ssLD-ILKoSGalh..ElIcpN++QSNlIousNNpLIp..lpppLsscIppFHuILDpTloKLNDAcWCL....sshlEp..KKKh-...........................EhK.lKEEtt...+K+c........EpEt..tcp.tct.........................................................................	1	18	27	38
+11047	PF11215	DUF3010		Protein of unknown function (DUF3010)	Pollington J, Finn RD	anon	Pfam-B_003238 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	77.50	77.40	19.00	18.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.52	0.71	-4.25	31	135	2009-09-11 10:24:04	2008-08-12 16:16:03	3	1	126	0	48	117	14	136.00	43	95.65	CHANGED	M.+lCGVELKGsEAIlsLLshcsshaslP-sRsp+hslscsssspsl+pFphsFscLhpDYpV-pVlI+cRtpKGKFAGuAsuFKlEAAIQLl..sslpVsLlSssslKppLK+sPh.lsFptsGLKpFQ.csAFpsAauhL	..M+lCGVElKGuEAllsLLo.hcsssasls-sRsp+hslscsssspsl+cFphsFtKLhpDYpV-cVVI+cRppKGKFAGuAsuFKlEuAIQLh..ssls..VpLlSPssIKpphK+sPh.lsFcpssLKpaQ.cpAFpsAYAh.....	0	8	17	36
+11048	PF11216	DUF3012		Protein of unknown function (DUF3012)	Pollington J, Finn RD	anon	Pfam-B_003254 (release 23.0)	Family	This family of proteins with unknown function is restricted to Gammaproteobacteria.	20.40	20.40	21.70	21.00	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.32	0.72	-7.56	0.72	-4.27	16	235	2009-01-15 18:05:59	2008-08-12 16:33:21	3	3	142	0	40	118	13	31.90	62	64.02	CHANGED	VGSEsWCccM+-KPKGDWTANEAs-aAKHClh	.VGScuWCEDMcEKPKG-WTAp-As-aAKHClh.	0	7	14	29
+11049	PF11217	DUF3013		Protein of unknown function (DUF3013)	Pollington J, Finn RD	anon	Pfam-B_003257 (release 23.0)	Family	This bacterial family of proteins with unknown function appear to be restricted to Firmicutes.	25.00	25.00	35.40	35.30	18.90	18.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.98	0.71	-4.50	12	479	2009-01-15 18:05:59	2008-08-12 16:37:24	3	2	473	2	34	218	0	155.00	58	98.53	CHANGED	MuKhshLshL-Epl-Kp.FsaDhtlsWDKKNHAlElsFhLpApNssulchsDspGpsSsE-Il.FEDtlLFYNPsK.SpFD.t-DYLsslPY-sKKGlu+phLshFspaLp-sh-pG.sDLMDFL.sDsss-pFtLpW-spsFEpshsp..LpEs-...aYsYP+	...MApaGFL-lLEEELDKp.FsaDaplsWDK+NHAVEVoFlLEAQNs.u.uVEhlD--GElSs-DIl.FE-uVLFYNPuK..Sshs.tEDYLssIPY.PKKGhSREFLAYFAhFLKDsA-.GLcsLMDFL.pDs-AEEFshcWspEsFEcG+ss..LcEsE......FYPYP+...........	0	4	14	23
+11050	PF11218	DUF3011		Protein of unknown function (DUF3011)	Pollington J, Finn RD	anon	Pfam-B_003246 (release 23.0)	Family	This bacterial family of proteins has no known function. Most members belong to Proteobacteria.	25.00	25.00	25.00	26.20	24.10	24.00	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.02	0.71	-12.00	0.71	-4.54	5	96	2009-01-15 18:05:59	2008-08-12 16:42:20	3	3	52	0	30	104	9	167.40	36	75.04	CHANGED	VVRCES+DpcRVHCDhsscsGlQLVRQLSuoSCI+GSpWGoDRuGVWV-pGCRAEFsuu.....supGuuaPusst....hRRlVRCESNGs+p.SCPVtLRGAPVRLLRQLSlhPC+EGRoWGp++sEIWVScGC+GEFElAc--GpsFVDs...........PaoLTCESKsR+RRoCGsSlcpG.sVLppQLSuTPCEEG+oWGWS..RssVWVssGCRAEF	................................................lpCpSpc.tphcCsh.httts.LVcplStspC.cGppWs.c..ptt..lWVppGCRucFstt.......ts...shst............ttslRCcSs.stt...C..sshh.Rts..pLlRQhS.hPChcspsWs...ctsplWVscGCcGEFt.ut.....ts.G.....s.hssh.......................shhlsCpScppphptCshss.p..ht..shlhpQhSpo.C.EspoWGas..pstlWVssGCRAcF..............................................................	0	8	20	25
+11051	PF11219	DUF3014		Protein of unknown function (DUF3014)	Pollington J, Finn RD	anon	Pfam-B_003267 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	127.80	127.20	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.68	0.71	-4.35	31	126	2009-01-15 18:05:59	2008-08-12 16:46:51	3	1	121	0	57	133	68	160.20	37	55.15	CHANGED	-llR+hVVhlDNLApGphsp+htPlpsPptpFsVpc.......sspth....IssssYpRYDsasshlsulsspphsshYpchpPLhppAYsELGYPcttFsspllpAI-plLss.PhscsPlpls...........psuVhYpFADPpLEuLssuQKhLlRMGPcNs++lKutL+cl+p	..cllR+hVVhVDNLupup.lsp+h.Plpsst.....ppFpVsph................ssphh....lss.ssapRYssYVshlsulDspshsphYpchhPLhppAasELGYPc.tt.FN-RllpAI-hLLss.PtspsPltlh...........pspVpYpasDPpLEuLssuQKhLlRMGP-Ns++lKutLRcl+.s..	0	12	30	46
+11052	PF11220	DUF3015		Protein of unknown function (DUF3015)	Pollington J, Finn RD	anon	Pfam-B_003292 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.80	26.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.81	0.71	-4.59	16	196	2009-01-15 18:05:59	2008-08-13 09:16:49	3	1	165	0	52	142	74	138.20	38	88.21	CHANGED	AhAsustGs.GCGhGs.MlFpGpsGhssHlLAuTTNGTSGNpTFGMTSGTsGCsosu..slshsupshlhhss.h-pLucDMA+GpGEsLsuhAslLGlpspD+s+Fstlh+cpFspIFsst-s.TucclhsuhhslhppDspLuKYst	....................................h..A.Assss.GCGhGs.hl...FpG...Q..cGhss+lLAuTTNGT.GNt......TFG.hToG.TsGCpssu....tl.shsucshhhhss.h-pLucDMAhGpGEuLsshAslhGltspD+scFstls+ppFu.pIFsssss....outpVhssh.slhtpD.hLttYs............................	0	17	31	44
+11053	PF11221	Med21		Subunit 21 of Mediator complex	Coggill P	anon	manual	Family	Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator [2].	28.80	28.80	28.90	29.10	28.40	26.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.78	0.71	-4.22	30	284	2009-01-15 18:05:59	2008-08-13 10:00:02	3	4	250	3	206	269	0	134.00	30	86.37	CHANGED	MuDRL.......TQLQssLDQlspQFsuolsalspspsss.hsssp........................phustpsss...........................................................sspsFpsphcELupDlllKs+QI-hLIsSLPGlssStccQh.cpIccLpcELpplEp-+tctl+ct-pLLccl-pllsslspu	...............................................MuDtLTQLQssls..p...lAppFssslshlpppts.sphss.p...............................................thsptps.................................................................spshppttp.hApslhhps+..pI-...hLIsoLPu....-..s..otptQh..pplpcLpc.E.cpstpphpcslpct-.tLLcclpshltslsp.s................................	0	67	112	168
+11054	PF11222	DUF3017		Protein of unknown function (DUF3017)	Pollington J, Finn RD	anon	Pfam-B_003304 (release 23.0)	Family	This bacterial family of proteins with unknown function appear to be restricted to Actinobacteria.	25.00	25.00	25.30	25.60	23.30	24.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.54	0.72	-4.19	44	367	2009-01-15 18:05:59	2008-08-13 13:05:21	3	1	325	0	76	203	15	71.80	41	71.31	CHANGED	PILlVshlhssuhsLssusaWRRGALlIGIGVGlAAlLRLsLo--RAGLLsVRS+sIDFlTTsTVuAAMlYIAhTI	...............hhhhh.hhhhuhl.ls....h....s..s....aW..RRGshllGhullhAAlLRlVL.s-pp..AGLL.uVRSRhlDhlhhss....lGAsMVhlAhTl.....	0	25	60	73
+11055	PF11223	DUF3020		Protein of unknown function (DUF3020)	Wood V, Coggill P	anon	Wood V	Family	This family of fungal proteins is conserved towards the C-terminus of HMG domains. The function is not known.	25.00	25.00	27.60	27.60	16.50	17.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.42	0.72	-3.56	11	47	2009-01-15 18:05:59	2008-08-13 13:24:13	3	3	35	0	35	50	0	48.80	43	5.16	CHANGED	NRcRKK+.WRctNuc+NK-NDL+SRlh.....KKApthaGpcso.tcKpsWh--EF	.....N+cRK++.WR-tNsp+N+-sDLRuRlp.....KRAsthFG.cp-o.tcKppWl--EF..	0	12	25	35
+11056	PF11224	DUF3023		Protein of unknown function (DUF3023)	Pollington J, Finn RD	anon	Pfam-B_003319 (release 23.0)	Family	This bacterial family of proteins with unknown function appear to be restricted to Alphaproteobacteria.	20.30	20.30	22.90	22.20	19.80	17.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.58	0.71	-4.49	35	63	2009-09-10 17:53:36	2008-08-13 13:36:20	3	5	5	0	38	59	0	122.90	21	52.07	CHANGED	shCIGpT.s.ssspLplhlsps.....pppphhsh...spGpSLFhlpsplssphlppst..pLpphhthsppp............spslphshYhLVsppslppFhp.stp..................ptphhshpslspaGsllhs+.....tpsshhch............FsEpcsLp	...........................hhCIGpT.t.ssspLhlhhsps.....p.pphh.....spGpSLFhlpsplssphltps...tLpp..hhthsppph...........pthlphphYhLVpppplppFhp.h.p...................tthh.hpslsphuphlhsp.....httt.hph............hsEtphL..................	1	8	8	8
+11057	PF11225	DUF3024		Protein of unknown function (DUF3024)	Pollington J, Finn RD	anon	Pfam-B_003325 (release 23.0)	Family	This family of proteins has no known function.	21.20	21.20	23.00	22.60	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.80	0.72	-4.09	30	192	2009-01-15 18:05:59	2008-08-13 13:40:33	3	1	180	0	35	131	2	57.50	36	48.42	CHANGED	thpsslA+lpaspspstWplahhcps......hcWp.Yp...cspsLcthLchlpcDspusFW	......hppslAKlhapcu.....pppWtLYhhcpp......ttWh.Ys.hspspsLoshlctVccDPcuhFW..	0	14	20	32
+11058	PF11226	DUF3022		Protein of unknown function (DUF3022)	Pollington J, Finn RD	anon	Pfam-B_003318 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	25.30	25.10	21.70	19.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.35	0.72	-4.19	13	102	2009-01-15 18:05:59	2008-08-13 13:42:54	3	1	53	0	25	82	4	109.60	39	85.85	CHANGED	-hsEL-pslsD.Fs-posssVHsDspoGRlplpluWltss.suss+thRpuVsLsh-ssslcRYAsLDsusRhRV+AhL+DhVcssL-p....LEDtptc.psVsl-lTss.LDsA	....chsELs+llsDhFP-Q.ophs.+sD.psGR.l.lpVpWluhRhuuos+..RpolslRhssssLtRYhuLcshtRuRs+AhL+AhscAsLsu....LE-p...cAsupsVsh-sT.htLs-t.........................	0	2	4	12
+11059	PF11227	DUF3025		Protein of unknown function (DUF3025)	Pollington J, Finn RD	anon	Pfam-B_003327 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.	25.00	25.00	59.80	47.00	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.46	0.70	-4.83	21	157	2009-01-15 18:05:59	2008-08-13 13:46:56	3	3	155	0	60	158	30	208.90	45	74.55	CHANGED	PlRFVsQst..LPsGpAYEsaIapTGpVPTR.-NLHDFFNALlWLpFPcsKstLNtlputsIupt..Glt.sh..RGslRDAlTlFDENGllll.uss.....sLtss.................Lcs+pWppLFlcpRstWt........ppspshhFGHALhEKLlpPaKulTAHshhl.l..sst.h..shsp.puhL-tpLs.....httushhss+sFuPLPlLGlPGWas-NpssuFYcDopVFRPtRR	...........lcFlsQss...LP.sGhAYEsaItpTGpVPTR.cNL...HDFFNALlWhtaP+hKutLNApQuss...Istt.....Gl....u..ss......RGslRDAlTLFDENGslhssu-.s.....s..Lt..sA.................Lpu.a-WppLhl.ppRstWs.........................s.pscshlFGHALhEKLl.sPaKulTAHuhhVpV..ssshh.th.....stsppp...............uhLDtpls......................tspthss+sasPLPlLGlPGWhstNtssuFYsDstVFRsuRp.............................................	0	10	35	48
+11060	PF11228	DUF3027		Protein of unknown function (DUF3027)	Pollington J, Finn RD	anon	Pfam-B_003334 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	26.80	25.90	24.90	18.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.32	0.71	-4.63	20	441	2009-01-15 18:05:59	2008-08-13 13:56:36	3	3	428	0	110	316	124	189.60	48	66.63	CHANGED	G-HLGspsEu-+lsTHhFtsphPGYpGWpWAVTVu+sscucplTVsElsLlPGssALlAPcWVPWp-RlRPGDLGsGDLLPsssDDPRLssGa.......................................ssssDstl-.................psshELGLGRpRVLSttGRppAAcRWY-G-tGPcothA+sAP..ssCsTCGFalPLuGuLsphFGVCANEhuPsDG+VVuhDHGCGAHSEs.l	...........................................G-al.GshsE...s-plsTHhFtsphPGYcGWpWuVslupss...c..u..cp.sTVsElsLlPGt..cALLAPpWVPWc-RlR..P..GDl...us.....GDlhssss-D.PRLtPGa..........................................................................................s.s.stD.st......................tsstE.lGLGRp+lLSt.GRspsApRWhsGphGPcsshu+...pAs....tsCso.CGFalsLsGoLst.hFGVCuNEaS.uDG+VVphcaGCGuHS-s.s...........................................................	0	32	80	102
+11061	PF11229	DUF3028		Protein of unknown function (DUF3028)	Pollington J, Finn RD	anon	Pfam-B_003337 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	19.00	19.00	20.50	25.00	18.20	18.40	hmmbuild  -o /dev/null HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.87	0.70	-6.24	3	60	2009-01-15 18:05:59	2008-08-13 14:00:20	3	4	42	0	35	71	0	530.00	60	38.40	CHANGED	MNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGNRLLPAWIKlVLTEGAPTMLCLAALHGMVALVGSEGDVMQLKSEAIQoSHFQGRLNEVIRTLTQVISVSGVIGLQSNAIWLLGHLHLSTLSSNQSRTSVPTDYSYLPEuSFIRAAIGFFITGGKKGPESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQAQSSQNAAoLLGLWVMPPLIHGLSLNIKKYLLlSsPLWIKHlSDEQIlGFVENLMVAVFKAASPLuSPELCPSALQGLSQAMKLPSPSHHLWSLLSEATGKIFDLLPNKIRRNDLELYISIAKCLSEMTDD-ANRVAQITKSNIEKAAFVKLYLVSQGRFPLMuLTDlLSVAVQHREKETLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSlQNVALDEALDFLLLIFAAAVVAWADHsAPLLLGLSASWLPWHQENGPAGPAuSLLGRSPMHRVTLQEVLTLLPsSMsLLLQKEPWKEQTQKFIDWLFSIMESPKEALSAKSKDLLKATLLSLRVLPEFKKKAVWTRAYGW	.....................MNKLRhLsEssQQTSGFALALGNlVHGLSVCGHGKAEDLus+LLPuWI+lVLsEGsPTMhCLAALpGhVALVGSEuslhQLKS.EsIQoSpFQuRLNEVIRTLTQVISlSGVIGLQSNAhWLLGHLHLSoLSSsQSRsSVPoDYSYLPEsSFIRAAIsFhlsG...GKK..G..PEuVPPSLlKlVMKPIAoVGESYQ..YPPVNWAALLSPLMRL.NF..G...EEIQQLCL.EIhVTQA.....QSSQNAAsLLGhWVhPPLIHuLSLshK+YLLlShPLWhKHVSDEQI..uFVEsLhVslF+suS....hssPELC.SALQGLSQ..AMKLPSPu+HLWSLLs-ATtKIFDLLPNKIRRsDLELYIulAKCLSEMTD--.ssRlsQlTKuNlEKA.AFV+LYLVSQG......RhPLhsLsDlLosAlp...HpEKEsLAWMlLHSLYQAR.I.VSHA.NTGVLK....RM.EWLLELMGYIR.NVAY..QSTShQNs.sLcEALDFLLLlFAsAVVAWADHs.APLLLGLSASWLPWHpEsGPuG...ss.suhLG+SPhcRVTLQEsLTLLPsSM.LLLpKEPWKEQTQK..FIDWLFSIMEuPcEuLSApS+DLLKATLLuLRsLPEFKKKAVWTRAYGW.........................	1	6	8	17
+11062	PF11230	DUF3029		Protein of unknown function (DUF3029)	Pollington J, Finn RD	anon	Pfam-B_003347 (release 23.0)	Family	Some members in this family of proteins are annotated as ykkI. Currently no function is known.	23.00	23.00	23.10	23.00	22.90	22.70	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.88	0.70	-12.60	0.70	-6.31	19	631	2012-10-01 23:28:04	2008-08-13 14:10:42	3	1	584	0	51	368	5	448.40	70	94.14	CHANGED	sLoh+QKpphLAhEAEssLshhplsstspcth....cpGlICDhFEGaAPa+PRYlLPDYA+FlppGScaLELsPspDlDEALNsLhIlY+HVPSVTshPVYLGpLDsLL.PFlpths--plYpKLKhFhlhLDRTLPDuFhHsNIGPsDshhsRhIL+l-uELKQssPNLThhYD.-lTPD-hlp.AspshhpCSKPahANashaspsas.psaGIVSCYNuLPluGGu.TLVRLNL+plAc+Apu.h--FhsplLPcYsphhhplI-sRtpFLhEESpFF-o.FLV+EGLIccsRFssMFGIaGhAEAVNhLlpp-shpp+..............YG+scpANpLGhpI.ppLsclVsspsstY..uhssRhLLHAQuG..I.shDpsVTPGsRIPhGcEP.-.lsHlpssAtaHpYasSGISDIhslDcTl+pNP-AhlslsKGAhshGhR.FTsNlussDLlRVTGYhVKhSDltKacp.cuuRpNTThLGutAscNoplhpRps.R	...........................................................V.LoPEQKRHFLALEAENs..LPY.Pp.LPs-ARcAL....DEGVICDMFEGHAPYKPRYVLPDYARFLANGSEWLELEGAKDLDDALSLLTILYHHVPSVTSMPVYLGQLDALLQPYVc.ILTQDcIDlRIKRFWRYLD.......R..TLP.DA.....FMHANIG....P....uDoPlTR.....AI.....LR.....ADAEL....KQVuPNLTFIY......DsEIT......PDDLLLEVAKNICE.CSKPHIAN..GP.V.aDKIF.......T......K...G....tYG...........IVSCY.........N.........S..L.........PLuG..GG..STLVRLNLKAlAERS.c........S..lD...DFFo.RTLPHYCpQQIAIIDuR...........CE...........FLYp....pSHFF..ENSFLV.......KEGLIsP..E......R..F.......sP.......MFGMYGLAEAVNLLCEpEG.lsA.R..............YGKpssANElGYRIS....AQLA-FVsNTPVKY.................GWppRAh..L..H.AQS..G...I...SSD.I.G.TTPGARLPYGDEP.D.PITHLQTVAPHHAYYaSGISDILTLDETIKRNPQALVQLCLG..AFK.AGMREFTANVSGNDLVRVTG..YMVRLSDLEKaRA.EGSRTNTTWLGEEAARNTRILERQPR......................................................................................................................................................................................................................................................................................	0	14	27	38
+11063	PF11231	DUF3034		Protein of unknown function (DUF3034)	Pollington J, Finn RD	anon	Pfam-B_003362 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	27.80	26.70	19.90	23.60	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.44	0.70	-5.02	28	135	2009-09-11 03:37:16	2008-08-13 14:21:12	3	1	128	0	44	144	8	247.80	49	87.40	CHANGED	ATGGloslEGuAGGGIsPWAlluGYuocsEhGuouhhTcVslsDYsLsshGAuluhtsRlELShA+QsFDlss....hust........................s.clpQDIhGsKlRLhGDllYsp...hPQlSlGlQaK+.c-.ts...............lspulGA.p-DpGoDhYluAoKLaLsuhhGpNlLlNsTlRuT+ANQhGLLGFGGs...pps.....sapl.hEuSlAllLs..+phAlGsEYRpKPDNLu..........hspE-DWtDlFlAaFPNK+LSlTuAYsDLGsIAsh.......ccQpGhYLSlQu	......ATGGsopIEGSuGGGIsPWAsluGYuopsEhGs.oAasT+lsls.DY..pLsVtGsul..uhsNRlELShA+QpFDlss..........htt.........................................s.plsQDlhGsKlRLhGDllYsp...hPQlSlGlQaK+.pD.hs................lPphlGA.ccDpGsDhYluAoKLahsuhhGhNlLlNuTlRhT+ANQhGLLGFGGs...pps............uhplhhEuSsAllls.....phAlGsEYRpKPs.NLu........................hupEsDWtDlFlAaFPNKHlSlssAYscLGpIAsh........csQpGhYLSlQ................	0	10	27	38
+11064	PF11232	Med25	Med25_PTOV1;Med25_PTOV-SD2; 	Mediator complex subunit 25 PTOV activation and synapsin 2	Coggill P	anon	manual	Domain	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [4].  The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This family is the combined PTOV and SD2 domains. the PTOV domain being the domain through which Med25 co-operates with the histone acetyltransferase CBP, but the function of the SD2 domain is unclear [3].	25.00	25.00	29.30	41.30	21.40	24.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.99	0.71	-4.54	7	184	2009-01-15 18:05:59	2008-08-13 14:21:37	3	11	64	4	76	182	0	147.60	62	31.02	CHANGED	.ppssp+.LhWSGsLEWpEps+s....sps+lp+oL.Cplhls.t-.p..lcT-pWPpKLhMQLIPppLLsslGshF.+sS+hV.F+.T..ssEsLcuLhphM...usGFAGClHF...PppssC-l+VLhLLYSsc+phFlGhIPpDQusFVptlRpVlspp+ps	...............ptlsNKhLAWSGVLEWQEKs+P...-sssKlpRoLPCQVYVNp..GE.s...L+T.-QWPpKLIMQLIPQQ.LLT.TLGPLF..RN.S..+h.VQFHF.......T...+.....Dh.EoLKuLhRIM....sNG.F.AGCVHF...Pap...u...sCEVRVLML...L..YSScKKIFhGLIPaDQSuFVNuIRpVIss+KQ.s.........	0	20	23	39
+11065	PF11233	DUF3035		Protein of unknown function (DUF3035)	Pollington J, Finn RD	anon	Pfam-B_003372 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Alphaproteobacteria.	25.00	25.00	25.30	28.10	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.91	0.71	-4.18	39	170	2009-01-15 18:05:59	2008-08-13 14:37:10	3	2	168	0	49	144	739	125.90	27	84.80	CHANGED	slsL...uuCut.....shpslttspssPDEFsllsptPLshPssas..LssPsPGssp.sD...sPpspAlsALsG..tt.......shssu-tuLlspAuphussssIRphlssE-tphtc+ssthsphhhhspsshhtshtpt..lcs.t-htthcp.sGstssuusP	......h.hhlouCut.....phtcsluhspssPDEapVhpptPLphPPsat..LssP..ssGt.s...p.p-....ssttpuh....tsl.s..............tshstupthllttu.st..t.tsshp......phthhtttt.h...hhh..t....s.....................................t...........................................	0	18	37	39
+11067	PF11235	Med25_SD1		Mediator complex subunit 25 synapsin 1	Coggill P	anon	manual	Domain	The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear [3].	25.00	25.00	53.10	52.60	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.54	0.71	-3.94	3	61	2009-01-15 18:05:59	2008-08-13 14:48:58	3	6	30	0	22	54	0	153.70	77	22.21	CHANGED	LPVGGu.SVPGsh.sKQ.VSLPPhsVlPPQluuAPQpPLPPV..pPPQMQVPQNsoLoAAHsAAQsAVEAAKNQKsu.uNRF..sslsPh.p.APuVGPPFSQsPAPsLPPG...P.hsPKPS....PASQsSLVTTVoPGsG.APV.hQQQssPQQPssPSMssTsAlGGV..QuPQPSQ.Q	.................LPVGGG.SAPGPLQsKQPVPLPPAsPSG.AoLSAAPQQ..PLPPV...PPQYQVPGN...LSAAQVAAQNAVEAAKNQKAGLGPRF.....SPIsPLQQAAP.GVGPPFSQAPAP.L.PPG...PPGAPK.PP.......PASQPSLVSTVAPGuGLAPs........AQP.GAPS.MAGTVAPGGV..SGPSPAQL.G........................................	0	1	3	7
+11068	PF11236	DUF3037		Protein of unknown function (DUF3037)	Pollington J, Finn RD	anon	Pfam-B_003382 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.30	21.30	22.30	21.70	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.27	0.71	-4.04	37	274	2009-01-15 18:05:59	2008-08-13 15:41:15	3	1	266	0	105	270	22	115.80	32	66.30	CHANGED	YAllRlVP+VERpEFlNlGVlLastpptaLts+h.plDc.pRLpuhssclDhchlpttLpuhptlCsGspsuGs..........luthshtcRF+WLoAsRSollQsStsHsGhss.DsstpL-+LhcphV	........YAllRhVP+VERpEFlNlGVllast.p...ppalps+h..plcp..sRLpshs.s.ch......D.hsslcttLcuhcplstGsppuGs.............hut.s.h...spRF+..W.LsAsRSo..llQsS.sHsG..hss...D.ttpLc+LhcphV.....................................................	0	46	87	101
+11069	PF11237	DUF3038		Protein of unknown function (DUF3038)	Pollington J, Finn RD	anon	Pfam-B_003387 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	25.00	25.00	58.10	58.00	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.74	0.71	-4.45	26	109	2009-01-15 18:05:59	2008-08-13 15:46:52	3	1	71	0	43	118	119	162.30	35	84.26	CHANGED	hs++spp+LDLLLLAlEuLslsuuEuhLtsuppLsLpshhssRVpLW+hRssNPlR+us.pRpsLshtEscALlhllsthAcphpshlRplL......supp.s.hspthhupahcRFpshhpcRMN.+Rutl.hh.s.spphspLthcLLhpLhhsoGssGhpRLhhSLhD	......cphpppLDLlLLAlEuLshsuuEshLtsuppLsLpshlssRlsLW+hRssNPlR+ut..tRppLslp-A+uLlhIlsahA+phpshIRphL.h.pQhpppphs.tpshhLupYl-+FpshappRMN.c+stl.hh..s.p-plspLAlpLLhpLLFsoGssGhpRLWhoLhD...	0	6	30	41
+11070	PF11238	DUF3039		Protein of unknown function (DUF3039)	Pollington J, Finn RD	anon	Pfam-B_003408 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	21.80	21.80	34.50	32.20	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.87	0.72	-4.52	19	435	2009-01-15 18:05:59	2008-08-13 15:55:13	3	1	428	0	112	273	89	58.20	56	62.78	CHANGED	psGDp-RFuHYV+K-KIhESAlsGpPVlALCGKlWsPsRDPc+.aPVCPcCKEIYEshp	....s.suDs.+FhHYVpK-KIs-SAVsGs.VVALCGcVassoRsPc.....PVCP-CKcIY-uhp.....	0	33	82	104
+11071	PF11239	DUF3040		Protein of unknown function (DUF3040)	Pollington J, Finn RD	anon	Pfam-B_003409 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	20.90	20.90	21.00	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.67	0.72	-3.93	28	478	2009-01-15 18:05:59	2008-08-13 16:00:21	3	1	392	0	158	361	191	86.20	37	67.41	CHANGED	MPLSEcEpRhL-plERuLhs-DPcFAsslpu........sshptsstRph....lhulsshVhGlslLlsGlshphhh......lulhGFllMhuuslhu	..................MPLS-cEQR.hLcplEpuLhs-DP+FAsulps..........................sthct.ss.tRph.........lhu..s...s.h..h.l.lG.LuhLVuGVshspsh.........LuVhGFllMhuushh.............................	0	67	123	152
+11072	PF11240	DUF3042		Protein of unknown function (DUF3042)	Pollington J, Finn RD	anon	Pfam-B_003420 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	25.00	25.00	32.60	31.20	20.00	18.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.51	0.72	-4.17	17	543	2009-01-15 18:05:59	2008-08-13 16:08:46	3	1	531	0	49	136	0	53.90	62	94.27	CHANGED	h+pFspGhlsGsluTluAlAGulhshKKslI-P.EcKtshIEENRK+AsRKphu	..KsFuKGllTGVsuTVAAVAGAVauhKKpVIEPEEp....KsAFIEENRKKAAR+RVS......	0	8	22	36
+11073	PF11241	DUF3043		Protein of unknown function (DUF3043)	Polligton J, Finn RD	anon	Pfam-B_003428 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins. This cannot be confirmed.	25.00	25.00	79.90	79.80	23.10	22.40	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.16	0.71	-4.67	28	434	2009-01-15 18:05:59	2008-08-13 16:14:09	3	1	431	0	114	317	91	175.10	37	78.01	CHANGED	sKGRPTPKRcEA-s..................ARpR.......shs.p.-RKsu+ptpRsptpcccp+.ptuMhsG-EpYL.sRD+GP.RRalRDaVDuRhsluphhhPluLlllllhhl....ss.......splphh..sshshhllh.llhllDuhlLuR+lp+tlsp+FPc...psthulshYAhtRAhQhRRhRhP+PpV.cRGpp	.....KGRPTP+Rp-Acu.....................sph+.............pLs...p..-+Kts++ppR...tpt+c+ppc........uM.sG-...-...taL.sRDRGP.RtYlRDhVDSRh.slupahMPlALsllllhhs........s...........stlthh....hoh.shl.lll.llhlIDuhhLsR+lp+tlcp+FPs.......t.s.thul.shYAhsRAhQhRRhRsP+PpV.cRGc.t............	0	35	84	106
+11074	PF11242	DUF2774		Protein of unknown function (DUF2774)	Pollington J, Finn RD	anon	PRODOM	Family	This is a viral family of proteins with unknown function.	26.50	26.50	26.50	29.10	26.30	26.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-9.02	0.72	-3.98	7	26	2009-09-10 16:41:49	2008-08-13 16:41:06	3	2	25	0	0	18	0	60.70	49	66.55	CHANGED	hc.cVpVahh.+EtGhsFl-IA+th.slpup-suclWspV-pA+...tcFcs+EKVVYRK+hlN.Kh+p	...Mc.cVhVahL.HEoGhuFIEIA+cl.slpA+-sAhhWscscsAK...t+FcsREKVVYRKRhlNpKlKp..	0	0	0	0
+11075	PF11243	DUF3045		Protein of unknown function (DUF3045)	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as gene protein 30.1. Currently no function is known.	21.40	21.40	21.90	73.90	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.02	0.72	-3.75	2	40	2009-01-15 18:05:59	2008-08-13 16:59:00	3	1	39	0	0	16	0	88.30	84	99.19	CHANGED	MFVVHsIh-sc.NTTRDYGHVN.FFRspP.FRu.KDtcIFKcCVEQGFIYl.caahpG.thR.TTYp+oLppL.DElhYNRsVsph.c.c	MFVVHTIYENEGNTTRDYGHVNQFFRCNPE...F..RAQKDERIFKKCVEQGFIYV....KHWM.....QGNKVR.TTYHRSLTELNDELIYNRAVNQTLKDE...	0	0	0	0
+11076	PF11244	Med25_NR-box		Mediator complex subunit 25 C-terminal NR box-containing	Coggill P	anon	manual	Domain	The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR [3].	28.40	28.40	28.60	28.90	26.10	28.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.34	0.72	-3.53	7	67	2009-01-15 18:05:59	2008-08-13 17:52:11	3	7	31	0	14	67	0	76.00	58	13.24	CHANGED	pppptstsshs...pQsht..p.............h......sstp...pQh.Q.hus..GQhhhpusspus....thp...ttpshtst....shhh.hh	.......................HLQPPGAPALLPPPHQGLGQPQ............LGPPLLHPPPAQSWPuQLPP.RAPLP.GQhhhuGGsRuPlspsGLQP....SVMED.....DILMDLI.........	0	3	3	4
+11077	PF11245	DUF2544		Protein of unknown function (DUF2544)	Pollington J, Finn RD	anon	PRODOM	Family	This is a bacterial family of proteins with unknown function.	25.00	25.00	25.50	70.20	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.63	0.70	-5.02	8	347	2009-01-15 18:05:59	2008-08-14 09:01:38	3	1	334	0	4	148	0	222.80	56	84.50	CHANGED	FaLsVsTPcuVtYGpYK..uhhhps-pLsllSWoG..uusAPolsLpDhsp.lspSsCPGLps.......osWs.CshhshsVhV-uDl..a.GCPWlVShassSpsPh......uhssYsGPss+sSlCPoVsVAsYDlSWsENYVsHsKsLpLQSTGGslEpTLSTYLMEsGKLCDGSpa...D-RGAYCRaVuQhlTFoooGCDsAcVTVTPscHPITDKQLHDMVVRVDTSS..RQPIDSTCRFQYlLNEL	.....F.loVlTPppVtYG.p.Yp...o.h..s.hpG-sLpllSWS...G...sssAPoLsLpDacs..lspSsCPGlst.......phap.CuhhThclTV.so.D.s..Y.GCPWlsSh..ashosss.......uhsoYouPTs+solCPolPVuoYDISWsENYVsHsKsLpLQSTGuslppTLSTYLMEuGKLCDGSpF...DsRGAYCRhVSphlTFoo.GCDpupVTVTPsRHPlTD+pLHDhVVpVsTSS..pQP.IDSTCRFQYlLNEL.............	0	1	1	2
+11078	PF11246	Phage_gp53		Base plate wedge protein 53	Pollington J, Finn RD	anon	PRODOM	Family	The baseplate of bacteriophage T4 controls host cell recognition, attachment, tail sheath contraction and viral DNA ejection. The structure of the baseplate suggests a mechanism of baseplate structural transition during the initial stages of T4 infection. The baseplate is assembled from six identical wedges that surround the central hub. Gp53, along with other T4 gene products, combine sequentially to assemble a wedge [1].	20.60	20.60	20.90	67.30	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.21	0.71	-4.84	12	70	2009-01-15 18:05:59	2008-08-14 09:05:47	3	1	68	0	0	63	1097	187.90	33	87.24	CHANGED	M.lFoaFsslcYtup.s.................ssIFRsa+hYastshhsaphcsYhlsGu.RPEplApplYGNspLYWllLMhNslhDPaasWlpsp-ssYphAtp+Ysps....splhaHhstpuc+a...aslVphPcsstsWYDh...............GspsppalpapGslts............VsshEtphhcNEp+RpItIlsssslpsFls-hhR.MEts	...............M.hFsaFssl.Ysspss.........tp....h.hpsIFRph+hhhchhthshhhcsYhIpsu.RPEplApplYGsspLaWllLhhNslhDsahsW.psp-shaptstp+Ysss....splhYalspc.spca...hsllphscs.tshY-h...............GshspphhphpsuLss...........................VssaEttlhcNEpKRpIpIlsss.lssFls-hh+.hEh.s............	0	0	0	0
+11079	PF11247	DUF2675		Protein of unknown function (DUF2675) 	Pollington J, Finn RD	anon	PRODOM	Family	Members in this family of proteins are annotated as Gene protein 5.5. Currently no function is known.	25.00	25.00	30.30	43.10	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.22	0.72	-3.93	5	48	2009-01-15 18:05:59	2008-08-14 10:08:16	3	1	22	0	0	46	0	89.70	54	82.40	CHANGED	MAMTK+FKVSFDVTAVlsSEsEcphc-sLl-LAKKAGAGEcl.oPh-REhLVQuLTHGsEGAsuFslKpGlREuIK-tasEhS..Dps.hKlSPATVREVF	...MshsKph+VoFphthhh.pp..tlLcK-hL+LsKpVGuGthV.Nu+Q+EhlVQhLTHGhEGlhoFVVRoShREAIKDMHEEYu..-KcoFK.SPATVREVF........	0	0	0	0
+11080	PF11248	DUF3046		Protein of unknown function (DUF3046)	Pollington J, Finn RD	anon	Pfam-B_3651 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	25.70	25.20	21.10	16.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.82	0.72	-3.99	23	439	2009-01-15 18:05:59	2008-08-14 11:27:04	3	2	408	0	109	273	72	60.60	40	73.10	CHANGED	MRLTEFaphlp-cFGsuYucslspDHVLusLGGRTsspAl-sGs-sRpVWpALCs-a..DVPtcc	.......MR.TpFaphls-tFGssaup.lstDpVLsuL.uuRTstpAl-cGl-s+tVWpAlCssh..-lPtp......	0	33	80	100
+11081	PF11249	DUF3047		Protein of unknown function (DUF3047)	Pollington J, Finn RD	anon	Pfam-B_3654 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.30	21.30	22.90	22.20	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.15	0.71	-4.90	39	127	2009-01-15 18:05:59	2008-08-14 11:30:24	3	2	110	0	59	135	779	187.20	27	71.98	CHANGED	ssuWp.hthss...tpTcYplh...pp....sspt.sl+AposuuASsLhpchslc.....ppssh..LpWpW+lsphhs..ssDtp............p+suDDhsuRlhVsFc....thshh.pht...............sLsYlWus.phshGsh..hsNPao.spsphlslpoGss.psGcWhscpRsltsDYc+sFG.........cc....sstlsululhoDoDNTsspupAaYGDIpl	..................................................tsWp.hth.t...ttopYphs..pp.......tsttsLcupucsuuSsLhp...p.hs.lc......hppssh..LpWpW+lpphhs..ssD..tp............p+suDDhshRlaVsFc.......thshh.pst................sLsYlWus.p.....tshGsh..hsNsas...s+sphll........lcoGss.psGpWhsccRslhtDac+sFG.........cc....sstlsululhoDoDNTtspupAaauDIth.............	0	18	40	53
+11082	PF11250	DUF3049		Protein of unknown function (DUF3049)	Pollington J, Finn RD	anon	Pfam-B_3659 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	29.00	27.60	24.70	21.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.83	0.72	-4.20	24	167	2009-09-11 15:04:28	2008-08-14 11:41:50	3	2	18	0	118	149	0	55.40	38	19.82	CHANGED	psFPPPlsolsttt......sthhhRscRc-GRLVlptVpsss.tp..hhpApRpsGRLpLphs	..........sFPPPlsolu..pts.........s.lhhRspRp-GR.L..l..LptVp...lss.pp...hhcApR.psGRLpLphh........	0	11	68	95
+11083	PF11251	DUF3050		Protein of unknown function (DUF3050)	Pollington J, Finn RD	anon	Pfam-B_3661 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.20	22.20	25.70	23.60	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.61	0.70	-5.12	32	145	2012-10-02 21:56:19	2008-08-14 11:51:00	3	1	136	0	65	178	375	227.80	46	88.88	CHANGED	pLhpHsLYpplpol--LphFMEpHVFAVWDFMSLLKuLQppLTssssPWlP.stssphtpLINEIVluEEoD.shpG.....thtSHFEhYLcAMccsGAsTptIcpFlphlppG.sl.tAlppsslPtsstpFlphTaclIpsupsHplAAAFsaGREcLIPsMFppllcph...shsppphspF+YYL-RHIELDuD-HGPhAhpMlppLCGsDspKapEstpsuppALcpRltLWDuI	...............................................LhpHPlYsplpolcsLphFMEpHVFAVWDFMSLlKpLQpcLTCsplPWlP.ssss.pstRLINEIVLuEESDpt.sG.......tthSHFELYLcAMc-sGA.sTptIcpFlphlp......pGhsl............tpALpp.s......s......lstssppFlptThchltputsHp.......lAAAFsaGREclIPsMFpsllcch...shs.spphspFpYYL-RHIElDu--HGPhAhphlscLCusDsp.+hpE.shpsuhpAlpsRlpLWDul.........	1	30	51	58
+11084	PF11252	DUF3051		Protein of unknown function (DUF3051)	Pollington J, Finn RD	anon	Pfam-B_3671 (release 23.0)	Family	This viral family of proteins has no known function.	21.30	21.30	21.90	299.10	19.20	21.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.33	0.71	-4.81	5	73	2009-01-15 18:05:59	2008-08-14 11:55:00	3	1	1	0	0	64	0	189.00	94	84.08	CHANGED	WLEHIRLIVVTMVPILLLPDTTIGRHIHIKRQYLQSVLLWLARNKLYYRVKRCRSKRFVLEQDHIGPELFRTQLLQYAGLDVFQDVARLQDFLERGYDTFRSVLGVHLLEHERFVSRILEQPIMEPDQAVRLCFHYHNTLDHDDDDSGLETDFNNLSLGRPYINGLPPNEKIIFIHSNLVGHSTsSHDI	WLEHIRLIVVTMVPILLLPDTTIGRHIHIKRQYLpSVLLWLARNKLYYRVKRCRSKRFVLEQDHIGPELFRTQLLQYAGLDVFQDVARLQDFLERGYDoFRSVLGVHLLEHERFVSRILEQPIMEPDQAVRLCFHYHNsLDHDDDDSGLETDFNNLSLGRPYINGLPPsEKIIFIHSNLVG+STYSHDI...	0	0	0	0
+11085	PF11253	DUF3052		Protein of unknown function (DUF3052)	Pollington J, Finn RD	anon	Pfam-B_3674 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	20.90	20.90	20.90	20.90	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.37	0.71	-4.54	19	439	2009-01-15 18:05:59	2008-08-14 11:58:01	3	1	432	0	121	286	61	125.90	48	86.46	CHANGED	Ap+LGhpsGtlVQElGaD-DsDp-lRcAlE-shGs-LlDEDs--VVDsVLLWWR.--DG...DLsDuLVDAhssLu-sGhlWlLTPKsGRsGaV-Pu-IuEAAsTAGLsQTousslGstWsGoRLlt.P+u+	......................................................Ap+LGhpsGplVQEhGWD-DsD--lRpslE-hhGs-LlDE.DsD-slDlVlLWWR.--DG...DLsDsLVDAh.ssLu.-cG.hIWllTPK.sG+..s..GplpPu-..luEuAsTAGLstToohsluptWsup+LVp.+..t....	1	38	85	108
+11086	PF11254	DUF3053		Protein of unknown function (DUF3053)	Pollington J, Finn RD	anon	Pfam-B_3678 (release 23.0)	Family	Some members in this family of proteins are annotated as the membrane protein YiaF. No function is currently known.	20.70	20.70	21.00	20.70	20.50	20.60	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.55	0.70	-5.10	8	635	2009-01-15 18:05:59	2008-08-14 12:50:38	3	1	566	0	51	216	3	224.70	65	95.30	CHANGED	sRhFtP.....LLAlLlsh.LuuC.GDKEPEQRKAFI-FLQoplhcS.Gs+lPsLTs-QKcsFGsYssDY.AILosFSQphspAlsuu.pssltQhssIRospDhls+RDsLcpupsuLshlupplpssKupADsA+usLKQP-DLKsVaDpAas+TVosPAssLhsslPhssuhlpsLlpVGDaLpsQGsQVpFsuuu......lQFpsspQsspaNphlus.....LssQtpshhsAQpplsslt	.................SRWFAP.....lsALLMVlSLSGC.FDKEGDQRKAFI.DFLQNTVMRS.GERLPTLTADQKKQFGPFVSDY.A.ILYGY...SQQVNQAMDSGLRPVVD.SVNAIRVPQDYlT.QpsPLRphNGSLGVLAQQLQNAKLQADAAHuALKQ.s.DDLKPVFDQAasKVVTsPADALQPLIPAAQsFTQQLVhVGDYIAQQGTQVSFVANG......IQFPTSQQASpYNpLIuP.....LsAQHQAFNQAWTsAVss.s............................................	0	2	11	30
+11087	PF11255	DUF3054		Protein of unknown function (DUF3054)	Pollington J, Finn RD	anon	Pfam-B_3684 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	25.00	25.00	27.60	26.90	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.56	0.71	-4.23	34	368	2009-01-15 18:05:59	2008-08-14 12:51:26	3	2	352	0	112	243	15	107.70	39	76.76	CHANGED	hlluDllslllFsslGRtSHups....hsssslhtTuhPFLhGhhluhhls...tuapt........pthhssulhlWlsslslGhlLRsh..putusshoFll...VuhsssullLlGWRulst	......lsuDVlsVllFuslGR.t.SHucs....LsssGlhpTuhPFlhGhslGWlls........tshpt......s........sthh.sGlllWlsTlllGMllRth..oupGsu...s...s...Fll...VAsshsAlhLlGWRAls.u...........	1	33	85	106
+11088	PF11256	DUF3055		Protein of unknown function (DUF3055)	Pollington J, Finn RD	anon	Pfam-B_3685 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Firmicutes.	25.00	25.00	26.80	54.90	23.30	18.10	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.61	0.72	-3.85	9	448	2009-01-15 18:05:59	2008-08-14 12:57:36	3	1	339	0	39	150	0	80.60	55	88.16	CHANGED	LYDDsEps+sRFVuFhGEppRaDLullaTsRaaGKsLVlshQosRFAIlGtDDlcEsGYLp+lapl.sEE-ApELppFLtEl	..LYDDsEpopVpFVGFhG.E.c.oRYDLhLlaTsRHYGKTLVLsMQTNKFuIIGsDDLcE.GYltHlhul.stEEu-ElppaLpEl.....	0	12	23	32
+11090	PF11258	DUF3048		Protein of unknown function (DUF3048)	Pollington J, Finn RD	anon	Pfam-B_3658 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as YerB. However currently no function is known.	25.00	25.00	72.10	30.40	24.20	19.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.65	0.70	-5.27	32	284	2009-01-15 18:05:59	2008-08-14 13:08:54	3	3	253	1	96	284	560	276.90	28	78.69	CHANGED	PLTGhss...pch..ptRPlAVhlsNt.ssApPQuGLspADlVYEslsEGulTRhhAlat.....ophsctlGPVRSAR.Yalchu.ta.cuhasatGuS.....spAhshlcsss...lsslsu.....h....sushF...hR.sssRpAP....HNhYsohcpltpsspp.puhphptt.t..........t.ssssssGptspplplpa....stspssapYD.psptYhRhpsGpsplDtsT....GppltspNlllhcsphpsh...DstG+hs..h-lh......GuGc..uhlhpsGphhclsWc+..sstpshhthhstsGpplshssGpoWl	.........................LTG..ht..tth..ptRslAVhlsNp.....ssA.RP.QoGLspADlVYEhh...s...EG.s.l.......TRhhAlap.....sphscplGPVRSuRsYalplupta.culhlatGuo.....st.sh.shlppss.....lsplss..........hp......sushF............aR..sss.RpuP...............HN..hYsshpplt.pshpp..pGh.......ph..stp.phh...........................tts......sss...s...s..uptsp..plplpa............sttps.papYst.psptYhR......h..t.s........G......p......s......p........hD.tps...........uptlsspNlll.tsshpsh.......DstG.p....hs.....lchh..................uuGp..uhlhpsGchh.cspWp+........ss..sps.hhhhh..s.ts.G.p.......l.lssGpTWl........................	0	51	81	89
+11091	PF11259	DUF3060		Protein of unknown function (DUF3060)	Pollington J, Finn RD	anon	Pfam-B_3702 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed.	20.70	20.70	21.10	20.80	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.06	0.72	-4.35	29	317	2009-01-15 18:05:59	2008-08-14 13:35:01	3	2	141	0	67	209	0	62.90	38	39.12	CHANGED	sVuGssNslslsGsCssVTVsGssNpVss-s...lcp.lolsGhsNoV...................oYcsG.....sPpl.sspGus....Ns	....................sVsGssNolsls.GsCtsVTVsGssNpVssDs...lc..s.lslsGhsNsV...................sa+s.G.....sPpI.sstGssN.................................................................................	0	13	34	55
+11092	PF11260	Spidroin_MaSp		Major ampullate spidroin 1 and 2	Pollington J, Finn RD	anon	Pfam-B_001419 (release 23.0)	Family	Dragline silk is composed of two proteins, major ampullate spidroin 1 (MaSp1) and major ampullate spidroin 2 (MaSp2) [1]. MaSp1 contains five alpha-helices [2]. Only the C-terminus of the proteins are shown.	25.00	25.00	25.90	25.20	22.30	21.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.79	0.72	-3.90	26	173	2009-01-15 18:05:59	2008-08-14 13:44:16	3	9	43	3	0	180	0	82.40	52	17.94	CHANGED	susSRLuSsuAuuRVSSslSoLlSu.....GssssuuLussISslsSploASssGLSuC-llVQsLLElloALlplLuSAslGpVNhuus	.......suuSRLSSPsAuSRVSS...AVSsLlSu.......GssNsAALuNsISslsSQlSuSsPGLSuC-VLlQALLElloALlpILuSSsIGpVNhuus..................	0	0	0	0
+11093	PF11261	IRF-2BP1_2		Interferon regulatory factor 2-binding protein zinc finger	Pollington J, Finn RD, Bateman A	anon	Pfam-B_1430 (release 23.0)	Domain	IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and  C-terminal RING finger domains [1].	25.00	25.00	25.20	39.60	24.60	23.90	hmmbuild  --amino -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.75	0.72	-4.51	11	146	2009-01-15 18:05:59	2008-08-14 13:46:33	3	2	75	0	86	140	0	53.40	76	10.11	CHANGED	o+RQaCYLCDLPRMPWAMlaDFSEsVCRGCVNYEGADRIEhVI-sARQLKRsHG	...SRRQpCYLCDLPRMPWAMIWDF.....o..EsVCRGCVNYEGADRIEhV.I-oARQLKRuHG.................	0	21	31	55
+11094	PF11262	Tho2		Transcription factor/nuclear export subunit protein 2	Pollington J, Finn RD	anon	Pfam-B_002604 (release 23.0)	Family	THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability [1,2]. Tho2, along with four other subunits forms THO [2]	23.10	23.10	23.10	23.50	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.84	0.70	-5.37	35	353	2009-11-24 09:31:40	2008-08-14 13:48:43	3	7	271	0	252	345	7	279.40	35	17.64	CHANGED	pshshlsss.hassFWpLSLhDlthP..pchY-p..plp+lcpplpp..............tpsthpppp+chcplp..pphppLtsEtppH.hp+sppspppLpcppsp.Wh......ttsspplp........pFlppClhPRhlhSshDAlasu+FlphLaphpsstFshhshhcp...lhpsphLhshlhssTppEApNlGhFhsclLphlppWppcpp.hacc.s.......................hp.......p.pphhsac...papphla+Waphlhpslhp.........................................................................................................................sL..ppp-ahpI+.NulhhLppllshFPhlpphupplhptlcpltpp-............pRcDlplsusullupLp	........................hWpslosp.FYsTFWpLohYDltlP..pptY-c..Els+L+tphpsl................................................p-.pphs.s++c+..-+..cchp..sh.c+LhpEpccp.hc+hppshp+Lpp.c..Kc.p.Wh..................................tsscspplp..............phLQhClhPRslhSshD....AlYCu+Flc.hlH.p.pTPsFs.TlhhhDp.................lFp..s..lhhhlhsCTppEApphGRFLsphLcplt+W+s..-cs..ha-+Es...................................tshPGFhhhhc.................p.ss.lsa-...sF..++lhaKWHhplspuhhp.........................................................................................................................CL..pss-YhpIRNslhlLpcll..s..haPh..l...tph...uptlppplpclpppE.............pR.DlhhhAtuhhupL.........................................	0	96	149	211
+11095	PF11263	Attachment_P66		Borrelia burgdorferi attachment protein P66 	Pollington J, Finn RD	anon	Pfam-B_003349 (release 23.0)	Family	P66 is an outer membrane protein in Borrelia burgdorferi, the agent of Lyme disease. P66 has a role in the attachment of Borrelia burgdorferi to human cell-surface receptors [1].	25.00	25.00	29.50	39.60	23.50	19.50	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.44	0.70	-5.33	7	107	2009-09-11 05:11:33	2008-08-14 13:50:47	3	1	47	0	3	91	0	182.80	58	57.03	CHANGED	SDFSIhGHISKKAN........Tsccsp.FsPpsN+LpFsppRosNFAFSlGsGIGhAWNpD-GEKESWuIpGusSYSpRIFGpQDKKSGIGlGIoYGQNLY+PTSSN.plIQpIAtKoFpTLNAEISTYEDNKKGIIPGLGWIASIGlYDLLK-pPpSD..sIIssLTssTssp...sssps....loFscAsKl.GGALYIDYAIPlESIS.sTaIlPYVGsHhLG...SLpuScKolYLKsGLEL-pLIKLT	...............................................P.tNtLpFspppp.shtFShGsuIGhAWNpDpGEcESWtlpGupSYspRlFGtQDKKSGluhGIsYGpsLY+s..psop.phlppIutpuFQoLNsElSoYEDNKKGlIsGLGWIsSIGlYDlLRpKShEN...shhos.hosNppst.....oTssps.......loFp-AhKL.GhALYLDYAIPlcShSspsYllPYlGAahL.G...plp.sspplYLKsGLpL-pLI+hT.....	0	1	1	1
+11096	PF11264	ThylakoidFormat		Thylakoid formation protein	Pollington J, Finn RD	anon	Pfam-B_003380 (release 23.0)	Family	THF1 is localised to the outer plastid membrane and the stroma. THF1 has a role in sugar signalling [1]. THF1 is also thought to have a role in chloroplast and leaf development [2]. THF1 has been shown to play a crucial role in vesicle-mediated thylakoid membrane biogenesis [2].	19.80	19.80	20.10	55.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.27	0.70	-4.72	27	122	2009-01-15 18:05:59	2008-08-14 13:52:47	3	3	108	0	59	137	144	204.00	37	80.16	CHANGED	TluDoKRsFapsaP+sIsulYRRll-ELLVElHLLShpssFphDslFAlGlspsF-pFhpGYpPppchsslFsALCsussh-sppl+psApphtphspspshpplhpaLppt...stts.t.lts.htthttp.pa+YSRLhAlGLasLLppups...ttc.pphpchlcclupsLsLstc+VcKDLslY+SNL-KhpQAhELh-EhltuER+K+Ecptt	.........TVuDoKpsFhptap+PIsolYppllpELLVphHLlphppsFpYDslFALGlVTsa-phMpGY.Ppp-+suIFpAhhpA..lstDPcpYRpDApplpphA+ut.sssslhphhsp....ttphps.LtshhpthtspspFpYSRhaAlGLapLL-.uss........pcsphlcc.lspuLslspc+lp+DL-lYRusLpKhsQAhcllcEhlptE+KK+cppt.t........................	0	16	42	54
+11097	PF11265	Med25_VWA		Mediator complex subunit 25 von Willebrand factor type A	Coggill P	anon	manual	Family	The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex [3].	20.40	20.40	20.50	21.40	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.45	0.70	-5.32	5	158	2012-10-10 16:07:06	2008-08-14 13:59:46	3	13	86	0	84	159	1	182.70	42	27.72	CHANGED	Msss.Scu.hpt...VuDVVFVIEGTANLGPYFEoL+ocYILPsIEYFNGGPlsEo-..FGu-hGuTQYuLVVFNTsustPEshVQsauPTpssa-FlpWL-uIpFsGGGuESCSLlAEGLusALQhFDDhpcMRpplGQTshHRHCILICNSPPYlLPo..............sESsoYsG+TsDsLsslhs..ERuIaLSIIuPRKLPALRtLF-KAsssssl.s.possDYAK-PpHMVLl+Gls	...................................................s.lADVVFVIEGTAsLGPYapsL+ppYllPslEYF..suGs.s-pc...h.tp.h.sss.YulVVaposs.sh..spshlp.s.hu.Tpss.phlphlct......l.........pFhG.GGhEssu.lAEG......LusAL.thF-...-hpph.R.pt..h.......sps..p+hC.lLIsNS....PP..Y.hPs..............s-.sh..pa.pu.t..os....-p..Lst.ht..cpsIphSlluP.R+lPsLhhLap+Asss..h.......hshups.pahVLlps..s......................................................................................................	1	24	44	62
+11098	PF11266	DUF3066		Protein of unknown function (DUF3066)	Pollington J, Finn RD	anon	Pfam-B_3735 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.60	25.60	26.20	89.80	25.10	25.50	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.40	0.70	-4.64	15	78	2009-01-15 18:05:59	2008-08-14 14:55:13	3	1	74	1	27	84	174	214.60	68	92.46	CHANGED	DFsS-sYKDAYSRINAIVIEGEQEAHDNYIsLucLLPDct-ELp+LAKMEtRHhKGFpACG+NLpVsPDM-FA+cFFutLHuNFQpAhAEGKlVTCLLIQuLIIEuFAIAAYNIYIPVADPFARKITEGVVKDEYoHLNaGEpWLKtNF-osKtELpcAN+pNLPLVW+MLspVssDAclLtM-KEuLlEDFMIAYuEALssIGFoTREIMRMSAtGLs	.DFsS-sYKDAYSRINAIVIEGEQEAa-NYIsLupLLP-pp-ELt+LAKME.RHhKGFpACG+NLsVssDMsFA+cFFusLHsNFQpAhtE..GKlVTCLLIQuLlIEuFAIuAYNIYIPVADPFARKITEGVVKDEYoHLNaGEcWLKsNF-sSKsEL.cAN+tNLPLlhpMLsQVssDApVLuMEKEsLlEDFMIuYtEALssIGFooR-IhRMuAhuL.s.....	0	5	18	25
+11099	PF11267	DUF3067		Protein of unknown function (DUF3067)	Pollington J, Finn RD	anon	Pfam-B_3740 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	29.80	29.00	21.50	18.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.22	0.72	-3.92	16	113	2009-09-11 02:36:25	2008-08-14 14:58:43	3	1	93	1	61	110	105	98.80	42	66.27	CHANGED	ucElhpLLhc+WGtSYDlQLp+p+sR.....laLQVMWtYLEQtSFPLoEt-YhtHLsplsphLsthGtuptV+salpsT+-+PRL....GKAVSlPLcl...spRhsEal	...........................p-LtpLlhpKWG+SYDlQLh+p....c..tp......lalQ.......VMW.+YLEQpSFPL.oEpEYht+LsslAphLpsWGssppV+salpp.......o.......+-.......R.PRl.....G.K....A..VSI.l-h.....s.t+.sEah................	0	19	46	57
+11100	PF11268	DUF3071		Protein of unknown function (DUF3071)	Pollington J, Finn RD	anon	Pfam-B_3805 (release 23.0)	Family	Some members in this family of proteins are annotated as DNA-binding proteins however this cannot be confirmed. Currently no function is known.	24.10	24.10	24.70	53.90	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.98	0.71	-4.52	27	435	2009-01-15 18:05:59	2008-08-14 16:07:47	3	1	433	0	113	326	73	167.20	38	47.77	CHANGED	Mp-L+lVulssDGppllhpss....sG..ccaplslDDcLRuAlRts.............................................................hst.......splchEhss...................tLpPR-IQu+IRAGtosEcVAptuGhslp+VcRFttPVLtERs+sAchAptstssps............tsPu........TLuEllsptlss+Ghs.ssspWDAWRcs-spWhVplpapsutpsps.......AcWpas	......................M.cLplls.lpssuppllhpss.................u....ppahlslD-pLRsAltts...................................................................................................................phphphcs................................................sLsPREIQuRIRuGAosE-VAttuGlsls+VcRFAtPVLtERs+hsEhApsstsh+s............s.u.Push..........TLuEllspshsA+Gl.s.sslsWDuWRc-Ds...pWtlplpW.tuut..s..s..pp.........Acapap.............................	0	34	83	105
+11101	PF11269	DUF3069		Protein of unknown function (DUF3069)	Pollington J, Finn RD	anon	Pfam-B_3783 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Gammaproteobacteria.	25.00	25.00	71.90	71.70	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.76	0.71	-4.03	12	138	2009-01-15 18:05:59	2008-08-14 16:08:23	3	1	138	1	25	67	4	120.10	63	83.47	CHANGED	Vlsh-clPEpLh....shhsplhEssEtphpcuWsuLPASApslLsp.EpFHuhh.lupAahtlshlup.phs-hs-s.ss.pcpEYpu.lhs+lhcsslK-hlKpLKKARpDtshhpsh+pVht	VlEFDpVPEuMa....cMVTSIHEVSEEsVREAWDoLPASAQNlLDNFEQFHALlSVSQAFAGLNVMEEFPTLNLPcpMoEE-K-tYRAQLLDQVLHNCVKDMVKQlKKARRDPILKR-FK-VF.A..	0	2	6	17
+11102	PF11270	DUF3070		Protein of unknown function (DUF3070)	Pollington J, Finn RD	anon	Pfam-B_3804 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	28.60	28.60	16.90	15.70	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-7.18	0.72	-4.18	20	37	2009-01-15 18:05:59	2008-08-14 16:09:35	3	2	1	0	37	37	0	32.60	43	23.32	CHANGED	hAPsccPP...sE-sHEAP.sschssustpssssu	hAPscpP....sE-sH.uP..Schtsu.tsstspu.	0	37	37	37
+11103	PF11271	DUF3068		Protein of unknown function (DUF3068)	Pollington J, Finn RD	anon	Pfam-B_3769 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed.	25.00	25.00	25.60	25.40	23.90	21.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-12.03	0.70	-5.36	22	301	2009-01-15 18:05:59	2008-08-14 16:10:06	3	3	204	0	84	243	5	319.50	26	82.78	CHANGED	Rh...hushLhulGshhllhAlllshalsutltclPlDlssss..lstsssssh.s.stss.pt..thps..s.............ppphsstcstssDhlshpsspslhc.............scspphlpshssphslDRpouhslss..............psthssssh..shpGl.a+FPFcsE+coY.aaDshhppshshsasup...-slsGh..psY+FpQpls.sshs.................sh.hh.tt................sstssshshhYsssR.shW........V-PhTGslVphpEp.pchhsssstp................hshl-h.chshs-colps.lspAcctpsplthhschlPhshhhlGllshlsGlhL	....................................................................hushhluLG.ssLlh.hAlllstasssc.ltclPL..DlstTh....hop...s......s...s........s........shss......s..h.h.st....p...h..s.s...ssshsp.............................ppphsl.tssus...sD..s.lslplus..oltRtp.................................tpssssll.Ahs-phs.lsR.couhslsssst......................stpsss..ssl.....t+-Glp.Y+FPF.cTE.+.+..o.Y.aFDshspcshs....hsass-......ccl..sGh...ssY+FpQs....l.s.sslut.............................................tst.sh.hshssth.........................................sspphshshaYs..spR..shW........V-PhoGslVctpEchpcaaupsstp..........................chshhph.phphs--TlpptlstAcst..........pcp..lthhuchlPhshtslGllhLlsGhh...........................................	0	20	56	75
+11104	PF11272	DUF3072		Protein of unknown function (DUF3072)	Pollington J, Finn RD	anon	Pfam-B_3823 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.60	25.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.83	0.72	-4.31	13	81	2009-01-15 18:05:59	2008-08-14 16:19:39	3	4	79	0	40	88	5	56.90	53	46.16	CHANGED	NsEKDPc-WsTGDEPMTGAQASYL+TLsEpAG..EshsssLoKA-ASchIDcLpppsGR	.............hpKDPs-WsTGDEPMTGAQtSYL+TLuccAG....Eshss..sLTKA-ASc+IDcLpppoG+......	0	15	28	34
+11105	PF11273	DUF3073		Protein of unknown function (DUF3073)	Pollington J, Finn RD	anon	Pfam-B_3852 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	30.80	30.50	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.42	0.72	-3.44	29	430	2009-01-15 18:05:59	2008-08-14 16:25:40	3	1	424	0	111	261	50	67.00	49	84.81	CHANGED	GRGRAKAKQTKVAR-LKYpSPsTDhspLpREL..uG.........sspspssss-shsDc.st......................cpYuc.s-t.c	.GRGRAKAKQTKVARcLKYpSssTDh-pLpREL..uu........tstssp.sc.s.....-.-...s..hs..D.-.h.s-.................................tDcYsc.st..p......................	0	34	82	103
+11106	PF11274	DUF3074		Protein of unknown function (DUF3074)	Pollington J, Finn RD	anon	Pfam-B_3858 (release 23.0)	Domain	This eukaryotic family of proteins has no known function but appears to be part of the START superfamily.	27.50	27.50	27.50	27.50	27.30	27.20	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.31	0.71	-4.66	28	152	2012-10-02 19:24:03	2008-08-14 16:30:32	3	2	107	0	125	153	0	197.00	26	41.03	CHANGED	WhuR+SlHc..................uhsapcacptLpsp.......+s-sEcpa.............lcslsutchlpph..................tst.spsphplhplpapFPh..sho...sRsFsslllshchs.................................ptsscpahllShPlsc....................pss.tpshlpGpYtSVEhlp.hs.................................................................................tpssslEWhMsTpSDsGG..slP+Whpcp....uhPpuIspDlstFLcWs	..........................................................WhuR+SlHc..................shsapcappsLppp.........+s-sEppa.......................htslsuhcplpph..........................................tssphplhplpaphsh.....shssRsFssLllosphs...................................ts.cpahllShPhpt.........................................ts.s.ppshlhGpYtSVEhlcpl........................................................................................................................................tpsstlEWhMsTpSDsGG...slPcaltcp....uhPsuIspDsshFlpWh.................................	0	33	68	106
+11107	PF11275	DUF3077		Protein of unknown function (DUF3077)	Pollington J, Finn RD	anon	Pfam-B_3820 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	20.40	20.40	20.40	20.40	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.61	0.72	-4.02	19	142	2009-01-15 18:05:59	2008-08-14 17:03:34	3	1	33	0	59	171	1	73.60	36	84.52	CHANGED	TsGtssFhpttt.pst.sLFRlpPGlPhpcAh-puShLhGhl+cLThcu.M...-sc.hhhhAu+YLSuMAKALhDDhElGhp	................t.Fh...t...tt..sLFplpsGlPhccAhppAStLhssspcLshcuhh....cs.ppp.hha....AuhaLutMAKALlDDhths........................	0	0	0	15
+11108	PF11276	DUF3078		Protein of unknown function (DUF3078)	Pollington J, Finn RD	anon	Pfam-B_3846 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	29.80	28.90	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.09	0.72	-3.81	36	294	2012-10-03 17:14:37	2008-08-14 17:08:44	3	2	198	0	84	291	141	93.90	33	25.50	CHANGED	hsQsuFs.NWtuGGsssluus...hslshptNYc.+cchpWcNplphpaGlsptc..spc.......h+KosDplclsSphGh..c.ttspWYYShhhsF+TQFssGY	..............hsQstho.NWh.tGGps.shuhh...sslshptNYp...+p+htW-NplphchGhspspucs........................h+posDtlplsSphGh...p..ssppWYYohthpFpTQFssGY...............	0	31	75	84
+11109	PF11277	Med24_N		Mediator complex subunit 24 N-terminal	Coggill P	anon	manual	Domain	This subunit of the Mediator complex appears to be conserved only from insects to humans. It is essential for correct retinal development in fish.  Subunit composition of the mediator contributes to the control of differentiation in the vertebrate CNS as there are divergent functions of the mediator subunits Crsp34/Med27, Trap100/Med24, and Crsp150/Med14 [2].	25.00	25.00	25.80	28.00	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	990	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.89	0.70	-13.65	0.70	-7.05	6	199	2009-01-15 18:05:59	2008-08-14 17:12:07	3	4	83	0	82	183	0	558.40	40	94.03	CHANGED	hKsspLKQhILpAWKERWoDhQWuINlKKhhP+GVohDlhNLA-ALLpQAhIGsusNPLlLSYLKaulsuphVSauuVLssISKaDcFsRchClpALLEhh-.hsDsloC+GKuEEsI.Ls+AhlShVaWLLQhhstss-+hp-st-h..ssttEphLptshpsL-+llpSsh.hullaIuKhEEsp.asslccphLclsp.lss...........lsssplcsphccssoL.psh.pMhslcucpl.cshhsolpsLIhlEshhN.ssDTQ.hVtQLhhlKRhp+hPhshhhhEIh+AChluL.pss-socEhhWsAFTFlKlPQlLtpL+thspstp.pD.......ao.DVspAFEhLLp.TPLLDhhDp+CsCsslphLLpEhsKhtLLoEspscpLsAKRsu...hsspLKps-.Nus.pP.NsshILRAEPslosILKTlsuDaSKs.EuLLGVLsphLSGpSLDLlLusAuspGKLKoFsp+hIphNEaoKp.lsGEhuKsAslRAhLFDlSFLMLsalsQTYGSEVILSEuusS....FFEpWlpsCMsEcsKshNPcp.shp.sDssKVEpLlshLNsSs....phKhsphKWcElCLoIPAslhcVL.AWENtsLSstsIpKIhDNIKu+lCShAVCAsuWLsAahpMlt.DEp.KPhsMIpQLsoPlsu...EphhQ..ah+ERlslMspIlc+MptDVhppsssp.Khtsth.p.....ppLsu+tPlcEthc-sa+sVLEKGWlss+uhahL-oLLphGGsaWhsspLVccLL+pphhcchsRsh-llaAIhpLDhppsTlsLLuallPhLLhcpuphcslsDP.uRsLAKLsVaChloohpop.tstsSutptp++RpchcDhspL.sLDshpsSthMRhl.....ussp--sshhuusGsc.....uhsSShSASpL+s........lsh+EPLppsLtsLFhlhSphluocphuP+s.FV.pFlp.hVEsucp.phuslLphhP.uhVppLlKlsuhsc.KV..lLplhDLslPhGRphAspsls	.............................................................................................................................................................h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	26	32	56
+11110	PF11278	DUF3079		Protein of unknown function (DUF3079)	Pollington J, Finn RD	anon	Pfam-B_3866 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	21.50	21.50	24.90	42.80	20.70	19.20	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.91	0.72	-4.42	10	130	2009-01-15 18:05:59	2008-08-15 10:29:55	3	1	129	0	38	95	4	50.40	70	69.48	CHANGED	MAKKFPLHPuHPERICWGCDRYCuADALACGNGS-RTQHPsELFG-DWhtau	....MAKKFPLHPpHPERICWGCD+YCssDuLuCGNGSsRTQHPsELhG-DWYch....	0	5	18	29
+11111	PF11279	DUF3080		Protein of unknown function (DUF3080)	Pollington J, Finn RD	anon	Pfam-B_3870 (release 23.0)	Family	Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed. Currently this family has no known function.	25.00	25.00	48.50	48.30	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.10	0.70	-5.28	24	161	2009-01-15 18:05:59	2008-08-15 10:30:32	3	1	160	0	29	132	67	301.60	36	90.76	CHANGED	hhcsYhpRLAslLDss...s.sh.shsshsl...Ps+Rp....hhhslsclsluLL-h.hpLppC.pLtpLIuE+NS.LGKVtsshpchpYphphlpuhppCl......p.t.tspslpspLpphhppKpppLshthhNslhsscphcpthohusphLshst.tsphuchhsAlpplsthhtt.........tttpsphssppltph.cpLpppchhGpLhhShpptsthLsssTphLppp.stpslCssspssschphLpNlFhphYltplQPYlApLspthppLts.ltpltpphs.h...hss.hptah................................sshappa+pustpHVphWQpLacpC..uhssu	........s.F-cYlpRlANV.pts................shs.ss..hss.sL.......PcKR-....Lhls.lssloIuLLDu.YpLRpC.uLFpLIAERNShLGKVQDthpcacYQlsLLpulpsCL..................ss..splspsL+spLhslps.KpppLsspaaNhLasS-shRpQLo.uopahstph....shu-ll.ALcpLsslppp.................hhsp...pslsopsLs..stQEsLcKp+llGclhaSLspuosaLcssTptLcsp.sssllCusp+ss........s+hpYL+NVFpp.YlcclQPYLApLDptYhQLsstLshhpp.ps.....hs......................................hpssappFRhAsppHspaWQpLFtRCtlslG...........	0	7	14	23
+11112	PF11280	DUF3081		Protein of unknown function (DUF3081)	Pollington J, Finn RD	anon	Pfam-B_3884 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	64.20	64.10	22.50	19.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.60	0.72	-4.45	22	143	2009-01-15 18:05:59	2008-08-15 10:44:01	3	1	139	0	27	89	11	79.40	54	89.94	CHANGED	cl-hpphLpla-pIpppGcp..p-st.....YhhpGlpAapDaDGYTlaLpspsVsLslhFHNoYcl-Y..................-pccphspFh++lpslh	...L-ssKlLpAYEsVMpNGoP....TEaG.....KlYEGIEAauDYDGYNlahRGNGVELKlGFHNTYHLsY..................EQEHL+DSFLKKLuhL.A..	0	6	15	22
+11113	PF11281	DUF3083		Protein of unknown function (DUF3083)	Pollington J, Finn RD	anon	Pfam-B_3898 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	21.00	21.00	22.70	22.40	19.80	17.00	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.09	0.70	-5.31	12	45	2009-09-11 05:40:26	2008-08-15 10:44:43	3	1	40	0	16	36	16	301.00	55	87.65	CHANGED	ssYQpLSctlFpLsEcc-LpNlHlIANDKLPhVRapsEuYshpTscQllFFYNPtYHEupphahsssh+A+KlRllFLATG--lRuNSApFHp+VpphlpcLtspLslpp.plKlRDHQHLoYDlFAKuKGsKpoYGaKLRuIssRYpuRpCsLPpsaouloYsTlslPlsR+l+ppl.sp.psp-.assLYpplpDsFhpAspsppLs+sAMlANGlsPlVRNSch-plssssElQMlGFDPptppsphls+WsuscLV-olpFllsAuppDps-tGaGRFhNpVEpAl+shss-lsl-tp+p-lhlRFHQHISYp	......................sCYQsLSRhlFsLu-pa-L+NVHVIsNDKLPVVRaHsEAYChpTsEQlLFFYNPtYHEAppLasp-saRARKlRIlFLATG-DIRuNSAsFHh+VpclLscLhspLPlpp.plKlRDHQHLoYDLFAKuKGsKEoYGYKLRuIsPRY+ARpCpLPcshuuLTYVTVoLPLSR+LKptlhs-.sssD.FsPLYQ+LpDsFlcAsss+pLs+lA....MlANGLTPLVRNSKa-+l-upsElQMlGFDPsssEpQllp+W-uspLVEssHFsIVAuscDpcDtGaGRFMNpVEsAL+sFssElulD.-R-DLlVRFHQHISYp................	0	4	6	10
+11114	PF11282	DUF3082		Protein of unknown function (DUF3082)	Pollington J, Finn RD	anon	Pfam-B_3896 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	25.90	25.60	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.65	0.72	-3.92	20	104	2009-01-15 18:05:59	2008-08-15 10:45:45	3	1	98	0	52	104	104	81.20	36	44.12	CHANGED	cpuPLshLSGuloSuhlualsahLopplsshFAt+PsphSsslsQsIuoAl+TLllGhshLATFsFAFlulGLhllhlpsLh	...............................sPlpsLhGulhuusluhhhYtLosslsssFut+sls...s.s.h.sppIusslRTLlhGlshLATFlFuhlulGLhllslQlhh......	0	13	36	48
+11115	PF11283	DUF3084		Protein of unknown function (DUF3084)	Pollington J, Finn RD	anon	Pfam-B_3912 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	50.80	49.90	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.63	0.72	-4.12	16	146	2009-01-15 18:05:59	2008-08-15 11:08:44	3	3	145	0	52	150	102	78.60	44	18.38	CHANGED	uGalLIlulLlLGGlIATlGDRLGoKVGKARLSlFsLRP+pTAVLlTllTGolISAhTLulLhssS+pLRpGlFpl.-pI	.....ualLllslllLGGlIAhlGD+lGo+lGKpRLoLFsLRP+pTAlllTllTGslIuuhT.lullhhsScslRpuLFph-p........	0	16	36	50
+11116	PF11284	DUF3085		Protein of unknown function (DUF3085)	Pollington J, Finn RD	anon	Pfam-B_3922 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	25.10	25.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.92	0.72	-3.79	24	126	2009-01-15 18:05:59	2008-08-15 11:13:49	3	1	107	0	43	108	2	88.70	37	66.35	CHANGED	sslhLVtDcGVYlhusst..hs..sGp...hlsYApGCsPcts..--WachtRpthGGDDhsEhl-s..shlpphlpss.c...Lplphossplplhs	...stllLVKDpGVYlhuptu.cts......sGp.....hlAYAtGCsPcsD...--Wa-hucpphGGDD..FuEhlcs..shhppllpssts...Lhlph.osoplplt.s.........	0	4	22	34
+11117	PF11285	DUF3086		Protein of unknown function (DUF3086)	Pollington J, Finn RD	anon	Pfam-B_3929 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	23.60	23.60	24.20	96.50	23.00	23.50	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.55	0.70	-5.59	18	73	2009-01-15 18:05:59	2008-08-15 11:19:56	3	2	71	0	28	88	163	274.90	53	76.67	CHANGED	llplALp-LppRRpuLptEIEcLEpRKcplEpEl+ooFuGpSDsIA+RVKGFQDYLsGALQDLApSsEQLELVsQsshVpPSPLD....ppusssssss......tssssusupsFps-pcLIRptLppapppPDaYAsPWpLRRSlEshcsEhl-DWFFNQGGRGA..ShGSR.+NlLVuuAlIuILu-LYGDpFQsLVLAupPERLGEWRRGLQDsLGLuREDFGPsSGIVLFERuDALlERADRLEEcGElPLIlIDsAEcsV-lslLQFPLWLAFAusPp..Ehhp--c	..................................lp-uLp-LppR+psLphplEpLE+R+ccIcpEh+ooFAGtSpslAhRVpGFpDYLsGuLQDLutuAEQLELls..psshhpPu..Phs...........................ptttsstt............ssss.hsspsFpsppchI+phL-papppPDaYusPWpLRRohEshcsEhlpsWFFsQGGRGAlpShGSR.pNlLluSAlISILscLYGDchpsLlLAssPERLGEWRRGLQDsLGluRpDFGPspGIVLFEps-ALlp+ADRL.ccsplPLIlIDsuEcplslslLQFPLWLAFAssPpph.p..t...........................	0	3	18	26
+11118	PF11286	DUF3087		Protein of unknown function (DUF3087)	Pollington J, Finn RD	anon	Pfam-B_3938 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	22.60	22.60	22.70	22.80	22.50	22.20	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.82	0.71	-5.01	25	105	2009-01-15 18:05:59	2008-08-15 11:24:09	3	1	103	0	37	106	10	163.40	38	96.62	CHANGED	MpLppIDKppYR+phNhlhlshlusLslLSLshushLIuLFG.................stusuNF+aNLlGVlluhllsuslLp.ph+s+saMpElhYVWcLKQhhN+IhRKL++lKsAAspsD...hsAlhlLpFYYsu.+QlapLDsNTlTlsslpp-lspLppthtphuLslstcpa-sphL	..MpLppIsKphYR+phNhlhlshlssLslhSLshushLIsLFG.................spusuNFHhNLlGVllulhhssullp.plKs+PaMpElhYVWcLKQhhN+IaRKlpplKAAAp.psD...ssALhhLpFYYsu.+QlapLDsNTlTh.s.sls..p-hspLpphhtphuLsLshspacsshL..............	0	4	14	26
+11119	PF11287	DUF3088		Protein of unknown function (DUF3088)	Pollington J, Finn RD	anon	Pfam-B_3952 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	30.90	64.70	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.28	0.71	-4.61	19	111	2009-01-15 18:05:59	2008-08-15 11:28:02	3	1	87	0	36	105	3	111.40	45	85.00	CHANGED	s+DhLFLLcPGFtDsut.PGt.FaCscssslEGLLusaPsLtsplDVc+lsasRPRtslltLlG-spQSlPVLlLusspssssss...tstsspRFlsDsccIhchLupRaGhPcs	...........+DhLFLLcPGFtDstp.Ps..FhCsculslEGLLushPsLpsplDVc+lsasRPRcsllAhlGEscQShPVLVLus..stss...ssu...pshsspRFlsssccIhchLuppaGhs+.h...............	0	10	17	28
+11120	PF11288	DUF3089		Protein of unknown function (DUF3089)	Pollington J, Finn RD	anon	Pfam-B_3953 (release 23.0)	Domain	This family of proteins has no known function but appears to have an alpha/beta hydrolase domain and so is likely to be enzymatic.	23.40	23.40	23.40	23.60	22.80	23.30	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.58	0.70	-5.17	25	100	2012-10-03 11:45:05	2008-08-15 11:32:33	3	2	78	0	52	106	398	198.30	29	55.10	CHANGED	tssVFaVaPToa...hstu..tWNuslsssps...thtchhltspAusF.spssclaAP+YRQAoltAa.....h.sspsp..ustA...hchAYsDVtcAFctaLsphssuRPllLAGHSQGuhhLhcLL+ccIuGcP.lpcRllAAYlIGhs.lsl...-ts.sshtslPsCpsssQsGClloasoa..t........ttt..s.su.c..upsts.spphlCsNPlshsssss	.............sDVFalaPTs....h......ssss......h..Ns....sl...ssttt..tthspthlttpAusF.ssssplaAPhYRQssltsh...................h.tttss......spps.....hp.hA.YsDVtpAFchYLpph.NpG.RPhILAGHSQGuhhlhcL.L+..c...phssps.lpcRlVAAYllGhs.lss.....pth.tth.slshspssspoGClloasoh...s........................s.t..ths...........ttthhChNPhshtss.s......................................	0	23	42	45
+11121	PF11289	DUF3092		Protein of unknown function (DUF3092)	Pollington J, Finn RD	anon	Pfam-B_3988 (release 23.0)	Family	This viral family of proteins has no known function.	18.70	18.70	20.00	19.80	17.60	17.50	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.92	0.70	-5.18	4	77	2009-01-15 18:05:59	2008-08-15 13:33:13	3	1	69	0	0	37	0	267.00	88	99.20	CHANGED	MDLFMSIFTLGuITRQPuKIENASPASTVHATATIPLQAShPFGWLVlGVALLAVFQSASKVIALHKRWQLALYKGlQLVCNLLLLFVTIYSHLLLLAAGMEAQFLYIYALIYILQIlSFCRFIMRCWLCWKC+SKNPLLYDANYFVCWHTpNYDYCIPYNSVTDTIVlTSGDGhopPKLKEDYQIGGYSEDWHSGVKDYVVlHGYFTEVYYQLESTQloTDTGhENATFFIasKLVKDsspVQIHTIDGSSGVVNPAMDPIYDEPTTTTSVP	................MDLFMRFFTLGSITAQPVKIDNASPASTVHATATIPLQASLPFGWLVIGVAFLAVFQSATKIIALNKRWQLALYKGFQFICNLLLLFVTIYSHLLLVAAGMEAQFLYLYALIYFLQCINACRIIMRCWLCWKCKSKNPLLYDANYFVCWHTHNYDYCIPYNSVTDTIVVTEGD.GISTPKLKEDYQIGGYSEDRHSGVKDYVVVHGYFTEVYYQLESTQITTDTGIENATFFIFNKLV.KDPPNVQIHTIDGSSGVANPAMDPIYDEPTTTTSVP...................................	0	0	0	0
+11122	PF11290	DUF3090		Protein of unknown function (DUF3090)	Pollington J, Finn RD	anon	Pfam-B_3954 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	19.50	19.50	19.70	19.70	19.00	19.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.18	0.71	-4.79	15	303	2009-01-15 18:05:59	2008-08-15 13:34:29	3	1	301	0	84	177	117	172.20	51	88.62	CHANGED	asFDsP-RFVsGTVG.PGsRTFaLQARsGuRlVSVuLEKsQVulLAE+ls-LLDElsR+tG..sslPss.ssshsDscPL-tPl-EEFRVGThuLuWDscsppVVIEshuls-..............-sDsc....shs-ss-ssDsLRVhLssssARAFAcRApcVVuAGRPsCPLCGpP.LDPcGHlC	........hacpPDRFVsGTVGQPGsRoFaLQA.tc.s.uRVVSVhlEKpQVshLA-+lspLL-Elsp+hG..s.VPPs.ssp.hcDLu..PLcs...Pl..-tEFRVGTMuLuWDsEspplllEh..hAlo-s.................thDsu........llhs-sEpuPD.ulRVhlTsppARpFusRuppVVu.AGRPsCPLCupP.LDPE.GHlC....................	2	30	66	80
+11123	PF11291	DUF3091		Protein of unknown function (DUF3091)	Pollington J, Finn RD	anon	Pfam-B_3979 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	31.00	31.00	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.25	0.72	-4.05	11	57	2009-09-11 07:39:49	2008-08-15 13:35:06	3	1	1	0	0	77	0	93.00	33	58.13	CHANGED	IcpLp-EIc+DYssaSccslEclp+ppspLcphasp.pSctpNhTCs+PcNIstcDlpsLpshItcpppshhshshacL++caLhplpcsLpNsscc.SE	........hcphccEIc+cYssasccVhEclhppsspLcphasphQSctpshTCs...........cPcNIstc.DlssLpshItp.phshh.hshhpLcpphh.plhcphpN.spp.u..............	0	0	0	0
+11124	PF11292	DUF3093		Protein of unknown function (DUF3093)	Pollington J, Finn RD	anon	Pfam-B_4007 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria. Some members are annotated as alanine rich membrane proteins however this cannot be confirmed.	21.30	21.30	21.30	22.20	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.73	0.71	-4.39	23	347	2009-01-15 18:05:59	2008-08-15 13:41:23	3	2	338	0	90	226	64	143.40	38	85.77	CHANGED	shYcERLWsPhWWWlhushl...sulhAh.lshus.slhsh.lshAllhslusslhLhh.....upscIcV.......ssspLhsGcA+LPsshlucstslsssstputhGppLDstAallhRuWlsshVhlsLsDPsDPTPYWLlSTR+P-cLluALp	......................hYpERL..WsPhh..WWlluhul...hALh..sh.shh.uhs.u.Lssh.lshsll.ssl..ssssllth.....Gp..s+IpV.......ssttLhsGcAplPhshluRstsls.upstpushGpphDsuAFllpRsWltshlhlhLsDPsDPTPYWlVSTR+Pc+LhuAl.....................................	0	26	66	86
+11125	PF11293	DUF3094		Protein of unknown function (DUF3094)	Pollington J, Finn RD	anon	Pfam-B_4017 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	20.90	20.90	20.90	21.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-8.57	0.72	-4.50	13	47	2009-01-15 18:05:59	2008-08-15 14:02:50	3	1	47	\N	13	42	25	53.60	58	92.01	CHANGED	oSRLSPEDQp+V-pYLuuPQHQVERpPFRPWhLhllVLAVsIGLGLLSRLLShLs	..oSRLsPEDQp+V-pYLpuPhHQVERtPFRPWhLhhllLAVVIGLGLLSRLLShLs......	0	1	5	9
+11126	PF11294	DUF3095		Protein of unknown function (DUF3095)	Pollington J, Finn RD	anon	Pfam-B_4020 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as adenylyl cyclase however this cannot be confirmed. Currently no function is known.	20.40	20.40	23.20	22.50	18.00	17.30	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.20	0.70	-5.43	25	117	2009-01-15 18:05:59	2008-08-15 14:20:26	3	2	97	0	48	132	14	331.50	38	95.68	CHANGED	FYssLPs..hstFpplsDsstYpPLP-DWslsluDIVsSTtAIusGRYKsVNMsGAusIuAlhNuh....ssh-hPFVFGGDGAshAVPsshhcpuRpALussptascp-asLsLRlulVPVuslRspGh-V+VARausSsslsYAMFuGGGLuWAEsphK.......sucatlssssssst.PDLoGLSCRWspI..PucpGpIlSlllhPsssssstsattlhccllshs-p...sscuuHPls.ps.plphsspuLshEA...RhptG.....t.hhhppltllh.slhuhlhh+p....shphssasscpYhpplspNoDFRKaDDuL+MslDsss-ptcplcshLppupspGhl+YGLHtQspAlMTChVsoshpccHlHFlDGAsGGYAtAAppLKs	....................Fattlsh..hptF.ptlhDss.YpsLP-sWhlulsDIVsSTtAIupGRYKsVNhsGAusIuAlhNuh......sthchP..FVFGGDGAshAlPsshhttAcpALussttasppphsLpLRsulVPVsslRspGhDl+lARatsStphsaAMFsG....GGlsaAEtthK.......tupahl...sss.sst.PDLoGLSCRWssl..suppGtllSlllhPsssssstthttlhpcllshhct....p.ctu+Pl.st.p...t.thphs...p..slthEu......+stts......h..hh...hthhhlhhtshhhhhhhph....th...hsth..s..sppYhpplstsoDFRKaDDuL+hslDssspphpplpthLptutttGhhpYGlHppspAlMTChVsssh.pcHlHFlDGAsGGYAhAAttLK............	0	9	22	27
+11127	PF11295	DUF3096		Protein of unknown function (DUF3096)	Pollington J, Finn RD	anon	Pfam-B_4028 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	20.70	20.70	21.00	20.90	20.00	20.60	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.73	0.72	-4.45	19	138	2009-01-15 18:05:59	2008-08-15 14:25:07	3	2	126	0	65	135	5	38.60	59	76.26	CHANGED	PlluLIAGILILlhPRLLNalVAlYLIllGLlGLhshth	.....PlluLIAGILILlhPRLLNYIVAlYLIllGllGLhsh..h.....	0	12	33	47
+11128	PF11296	DUF3097		Protein of unknown function (DUF3097)	Pollington J, Finn RD	anon	Pfam-B_4031 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	46.70	46.60	20.80	20.00	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.73	0.70	-5.38	18	374	2009-01-15 18:05:59	2008-08-15 14:29:13	3	2	369	0	98	278	7	265.80	56	95.51	CHANGED	DcYG.pDVLAsstRsttht...ss-lPsEhGlVVE-suoGFsGAVVpsEput....VpLEDR+G+pRsFPLusG.FLl-GpPVsLstP..tsusAp.......PsR..TASGSlsVtutcARVApASRIaVEGpHDAELVE+VWG-DLRlEGVVVEaLcGVDDLsuhlAcFpPGPGRRlGVLVDHLVsGSKEoRIA-uVst.....sHVLVsGHPYlDIWQAVKPpplGlcuWPsVPRGp-WKpGlCptLGW.tu-pAD...uWpRlLupVcSapDLEPsLLGtVEcLIDFVTs	..............YutDlLu........st.......h..Rp......p..................ss-hPsEhGhVVEDss....oGFVGAVVthEpuh....VsLEDR+G+pRsFPluPG.FhlDGpPVsLstP....pt..usAu......................pR..TASGSlAVsutcARVAtsSRIaVEG+HDAELVE+VWGcDLRlEGVVVEaLsGlDDLsslVA-FpPGPGRRLGVLVDHLVsGSKEoRlA.-p.Vpp.....spaVLVsGHPalDIWQAVKPpRlGlpsWPcVPhspDWKpGlCctLGWPtu......stuD...uW.p+lLupV+sa+DL-PsLlGcVEcLIDFVTt.................	0	30	74	94
+11129	PF11297	DUF3098		Protein of unknown function (DUF3098)	Pollington J, Finn RD	anon	Pfam-B_4061 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	29.70	28.00	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.27	0.72	-4.26	28	232	2009-01-15 18:05:59	2008-08-15 14:34:55	3	1	213	0	70	203	188	67.00	45	81.64	CHANGED	hsFsKpNYlllhIGhslIAlGFhlMuGtsSss......tlauah+lplAPhlllhGasl.laAILhpP+	......hsFsKpNallLsIGhAllllGFlLMoG.......suSs.......-.ssF.p.s.-.IFShRRI+lAPlVsllGFlhhI.YAILh+P+...	0	28	55	67
+11130	PF11298	DUF3099		Protein of unknown function (DUF3099)	Pollington J, Finn RD	anon	Pfam-B_4064 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	23.20	23.20	23.40	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.61	0.72	-4.23	24	391	2009-01-15 18:05:59	2008-08-15 14:43:59	3	2	356	0	114	278	53	69.10	35	54.99	CHANGED	hITsAstohp--h+sRh++YslhMulRhssllLAslsh.....ualpllhls..sulsLPWlAVllAN.spssppppcs	...........hITsA.t.u.t.phct.R...+cYhhhMulRsssllhA.slsh.h.....shl.ulshls..sulsLPalAVllAN.sts.+psp..t............	0	34	89	109
+11131	PF11299	DUF3100		Protein of unknown function (DUF3100)	Pollington J, Finn RD	anon	Pfam-B_4068 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	20.20	20.20	21.80	22.80	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.52	0.70	-5.15	27	247	2009-01-15 18:05:59	2008-08-15 14:51:52	3	1	215	0	74	233	4	231.70	44	74.12	CHANGED	llluE.hIGshplslGsu.sllLLPhlaAlllGhhlshthh........phlsccptphAusllhlulh.LlA+hGsslGPsl.pllsAGPALlLQEhGpl.GTllluLPlA.llLGh+REuIGATaSIuREPslAlIu-KYGhcSPEG+GVLulYlhGTlFGslFholLAuhlushsh.FcPhALAMuuGVGSGSMMuAusGuLsuth.P.chscpIhAaAuASNLlosssGhYhslFluLPLsphhYphl	..................lluE.hIGhhphslG.u.pllLLPhlaAlllGhhlu.hthh........phlsccphphAuslltlulhhhhAKhGhslGsslspllpuG.........ALllQEhGpl.GTllluLPlA.llLGl+REAIGATaSluREPslAlIu-+YGh-SPEG+GVLuhYlsGTlFGslahullAuhluu.hsh.FcPhALAMuoGVGSuSMMuAAsuuLsshh...P.-...hucp.lhAhAAASNLloshhGhYhslFluLPLspahYch....	0	23	50	62
+11132	PF11300	DUF3102		Protein of unknown function (DUF3102)	Pollington J, Finn RD	anon	Pfam-B_4016 (release 23.0)	Family	This family of proteins has no known function.	20.10	20.10	20.10	20.10	19.80	20.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.57	0.71	-4.12	14	260	2009-01-15 18:05:59	2008-08-15 15:05:59	3	5	129	0	69	230	14	117.60	29	44.05	CHANGED	RTPhlIAuEINhI+cQopKhLLtsAlEIGRRLpEAKuLlPHGEWhcWLcESVuYSppTAspLMplacEYGphh................so.ssp-u..N..............ttshssLsYTQALlLL...GlPEEER-pFls-pDVps.MopRELpQAVcE+	................................EIp.h.pp....stp....hh.shlEIG+RLtcsK.....p.h.l..sHG.....-atcWLcpplsaSppoAp+hMplhcca.us.....................t...........t.........................t.h.pL.hppslh.Ll........sl..s-t.-c...phh........t..................-........l.tp...Moh+ELptslpp...................................................................................................	0	28	52	58
+11133	PF11301	DUF3103		Protein of unknown function (DUF3103)	Pollington J, Finn RD	anon	Pfam-B_4046 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	25.00	25.00	30.40	29.20	22.30	19.70	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.08	0.70	-5.75	15	133	2009-01-15 18:05:59	2008-08-15 15:14:23	3	1	126	0	20	86	3	341.20	63	88.23	CHANGED	KRpLAhpLScpYsplcssLpppIsphpLssslspLlppstsss....h.pphppA-pslRphKGlssho-s...............LLplRLADssMLsuWQpGc.sPLFAFEPsGDDcsWpYIEAYDltGplHhLDVYplP-pPVhVVDssupc-l+AGLtsM+sEhs............t...sspp.phtstusts....ppt.spupspsIsTTlLKKIRLpDDpEPWISGKAEIYAIVTGVsPSRDEPsLDlVEMPYLDYDcpsYYPNQllIaWsRYRWGAADllLMEpDDGTNYKpLAphLlcAAEplLKsIPDPEVQGYAIIsQITscIIcslPDuhhTNDDDFVDVaYTLhpspsYsDHsGAuGNAssTFsPLTIsPT	...........................................................................................KRpLApphSpsYAshtpoLKoQIospsLSlslS-Llcs.sPss-......hSpQLppA.DpslRolKGIs..paT-p...............LLQLR..LADsoMLppWQpGp.SPLFAFEPS.G.sDcsWQYIEAYDVYGQIHQLDVYQLPDVPVFVVDsDSuhELKAGLQAMRAEMp+L..........ttssplsspcSs.uhcsuspo....hspuusu-ssPISTTVLKKIRLpDD+EPWISG+AEIYAlVTGVDPSRDcPTIDLl-MPYLDYDcQDYaPNQllIHWsRYRWGAADhILMEQDDGTDYK-LAKpLVcVAEEVLKhIPDPEVQGYAIIsQITuKII-AIPDGVLsNDDDFVDVFYTLMQDTpYsDHPGAsGNAsATFEPLTI.PT................................	0	3	5	12
+11134	PF11302	DUF3104		Protein of unknown function (DUF3104)	Pollington J, Finn RD	anon	Pfam-B_4053 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	20.00	20.00	20.00	22.10	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.34	0.72	-4.60	20	52	2009-09-10 14:59:42	2008-08-15 15:35:57	3	1	25	0	24	55	153	68.90	44	75.02	CHANGED	shFLuV+sGDhVlVpsss..tsspttpp.sWWMGpVlpspGG....ARsPpssoLFQVADVDoGhI+WVNADpVo+llhshc	.....PhFLtV+sGchVlVpppp..........t.sWaMupVlhspGG....ARsPcssoLFQVADVDoGhIpalNAD.Vo+Il.p..s......	1	1	7	14
+11135	PF11303	DUF3105		Protein of unknown function (DUF3105)	Pollington J, Finn RD	anon	Pfam-B_4062 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	25.00	25.00	25.20	38.20	23.40	24.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.80	0.71	-4.31	37	224	2009-01-15 18:05:59	2008-08-15 15:41:28	3	4	181	0	135	235	28	128.10	34	48.60	CHANGED	ssH...lpts..lsYs.....psPPsuGsHsshWhsCu..hY..spsl.sppsVHsLEHGAVhltYcPs.lsssplppLpphsps.ts............hsllSP.....hss.hssPlslsAWu+pLpl.css--splppFlppa.........hpuP..ptPEsuAsC	.....................t..H.hphs..lsYs.....psPPsuGsHss....hWtsCst.lY..spsl.sEphVHuLEHGAVhlsYcPs..hsssp...lppLpphlpu.ts.......................hhlhSP..........h.s.....cs..PlsLsuW...........G+p..............Lpl.cssc.....D...tclspFlppa............hpss..phPE.su.C............................................	0	43	90	126
+11136	PF11304	DUF3106		Protein of unknown function (DUF3106)	Pollington J, Finn RD	anon	Pfam-B_4069 (release 23.0)	Family	Some members in this family of proteins are annotated as transmembrane proteins however this cannot be confirmed. Currently no function is known.	23.10	23.10	23.10	23.70	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.83	0.72	-3.63	30	277	2009-01-15 18:05:59	2008-08-15 15:48:36	3	2	230	0	106	262	41	94.00	27	48.62	CHANGED	sWscLossQppsL.uPLupcWss.hsstp+c+WlplAppasphoP--Qp+hppRMpcWspLoscQRppARpsapph+pLs....Ppp+p...ppWctYQpLssEc+ctLAtpt	...........................WtpLs..pp.hL.tsht.pWst.hs...p+p..+hh.p.hutca.phoPppppc.hptRhs.cWtphoP-pRctsRpp.ap.p.h.+pLs....spp+p......ppap.ta.ppLs.tp+pthtt..t.....................	0	26	67	86
+11137	PF11305	DUF3107		Protein of unknown function (DUF3107)	Pollington J, Finn RD	anon	Pfam-B_3881 (release 23.0)	Family	Some members in this family of proteins are annotated as ATP-binding proteins however this cannot be confirmed. Currently no function is known.	21.00	21.00	21.00	25.60	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.37	0.72	-4.10	26	426	2009-01-15 18:05:59	2008-08-15 15:52:41	3	1	423	0	109	263	78	73.40	43	94.06	CHANGED	MElKIGlpsssRELslpSsQos-EVpphVu-ALssss.GlLsLoD-KGR+hlVPssplAYVEIGssssR+VGFus	.MElKIGlpsusRElslsos......p...os-..-lcptlspALuss.s....ulLs.LTDcKGR+hLlPuspIAYVElGss.ssRpVGFG.......	0	33	80	101
+11138	PF11306	DUF3108		Protein of unknown function (DUF3108)	Pollington J, Finn RD	anon	Pfam-B_3856 (release 23.0)	Family	This is a bacterial family of putative lipoproteins. The structure for Swiss:Q64U78, PDB:3fzx, the first structural template for this large family including several homologues in the human gut microbiome and in metagenomic datasets, folds into a beta barrel that topologically looks like a small-scale porin (such as FepA). Swiss:Q64U78 is a putative exported protein, and this fold is of the YmcC-like type, with a predicted signal peptide SpI cleavage site AGAMA|QNQDC, and a Phobius server prediction of non-cytoplasmic localisation for amino acids 21-236. The possibility of it being a membrane protein can be ruled out by the hydrophilic nature of the solvent exposed surface outside the barrels. Analysis of sequence conservation suggests that an area near Glu172/Trp206 is potentially interesting. These two residues are also conserved in Dali hit PDB:2in5, a hypothetical lipoprotein classified as a new YmcC-like fold in SCOP (SCOP:159271, with a 12-stranded meander beta-sheet folded into a deformed beta-barrel) despite large structural differences between the two structures, suggesting similarity in function.	27.00	27.00	27.00	27.10	26.80	26.60	hmmbuild  --amino -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.52	0.70	-4.71	135	1119	2009-01-15 18:05:59	2008-08-15 15:57:36	3	3	918	1	417	1035	746	234.00	15	85.25	CHANGED	hlshhssssssusps........................................................stphpYplph.tsh.....thu...pushph......hpss....ttaphpspspssul.......h..hptthts....hhhst.tth....stpattptppsshppptp..hpFshp.ptpsh.................hptt.tp.sh.tsh...D..huthhhhphthtt.sh.........phshslhsscch.hphphph.........hup.Eplp.sstGp.hcslphp..................ttthhpp.ppshphWhu.......ss..hl.P.V+lcttt.........hG.shphpLsphp	........................................................................................................................h.......s..s...ttt..................................................................t................shphpYphph..tsh..........phu......pushph........tpss...................tsaplshp.sps.sth...................thhs...thth.ss..tslh...Ptpappptpt.tttpp.t.p....hpFshs.stpst................ttptpt.tphshtt.ssh.....Dh..hohhhpl.tt.htsssh.............shshtl....h.csc.ph..ph.p.hph.........hGp..Eplp..s.....s..s.G....p...hc..sl.....+hp.......................thhpp..ppp..hphW.hu........sshshl..P.V+lphhpt.......G.phph.l.t..t..........................................................................	0	129	280	358
+11139	PF11307	DUF3109		Protein of unknown function (DUF3109)	Pollington J, Finn RD	anon	Pfam-B_4077 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.90	20.90	22.80	20.90	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.26	0.71	-4.78	28	212	2009-01-15 18:05:59	2008-08-18 12:42:32	3	1	210	0	65	204	121	181.80	49	92.84	CHANGED	MlplGcslVSc-llcppFlCsLssCKGsCCVEG-hGAPLcpcEstlL-clhscV+shLpcculcsIccpGs.lpstpG-h.Tshl.su+ECsassatccGhshCuIEpAYppGhlsacKPlSCHLYPIRVp+hsshsAlNY-+WplCcsAppLGcEhpVPlYcFlKcALlR+aGcsWYp-Lcph	....................MlQlscslVS.DllcccFlCs..LssCKG...tCC.lEGDAGAPl-.-ElthLEclhstlh.s.Lsscutt.sI-cQGsshpD....p.-GD.lsTslV..s.s+-ClFssat-..........c.....G.....hshCAIE.+.A.Y.cpG.cscah.KPlSCHLYPI..Rlp..ca.s.s.ap.AlNYc.RWc.lCcsAsthG+chslPVY+FLKEPLIR+FGc-WYpELc..h..............................	0	23	50	62
+11140	PF11308	GHL1-3	DUF3111; GHL;	Glycosyl hydrolases related to GH101 family, GHL1-GHL3	Pollington J, Finn RD, Naumoff D	anon	Pfam-B_4091 (release 23.0)	Family	This family of bacterial and lower eukaryote glycosyl hydrolases is related to CAZy family GH101, and is made up of sub-families GHL1-GHL3. In the example Swiss:C02A26, the substrate-binding Asp is residue 596, the nucleophilic Asp is residue 706, and the proton donor Glu is residue 747.	25.60	25.60	25.60	28.20	23.40	24.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.10	0.70	-5.09	24	306	2012-10-03 05:44:19	2008-08-18 13:05:20	3	2	258	0	36	239	5	281.20	36	43.87	CHANGED	sLpp.hGlc+halth.DsWttuha...pP-hlssuccuG................YLhusaDpYtshh....pDtahsAp......htcptulpptDGohhtthp..usGhhh...sstshsaV+pphsclhp....ththsuhFLDV.uss.sp-sa........sscHhhscppshps+ptphpaltpc.sllhGSE-GsshsspslsFsH.........asst-hhtpcpus.ahG........hP...........................lPLYphVaHDslIs..........s.........Whhsp.ph.....ss.ppchhLhslLasssPhlphs.ts.hth....p.......htphhctpphhpshHcplsppchssachlststhlQ............pop	....................................hpp.sGlp+hWlGL.ssWt.uhh...pPphVspAcphG................YLlGsYDSYpohht.u.s.csW.TAph......ssphh-pssl.pptsGph.tGFh....upGhhLN.........P..s..hths.V+pRhpcIlp....hspaNShFlDsDuTu.hh-DY........pscc...hssppp.lpAt.pRhpalsp.p.shllGSEsGNshsspslsFAHGhpo.s.htWsDpcM+ps+pSsYYlGtaa....stthPth..ah.K.s.lKt.a+......plhhsP.YpVPLYphVapDplIo..........oa.......+Wt.solKh.....ps.hssR.LhthLaNsPPhhHLs.csphpp..........+.............hpplpca.psat.hHcphhccthssFpaLscpt.VQpo..............................................................................................................................................	0	16	23	29
+11141	PF11309	DUF3112		Protein of unknown function (DUF3112)	Pollington J, Finn RD	anon	Pfam-B_4107 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	23.30	23.30	23.80	23.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.06	0.71	-4.44	32	153	2009-01-15 18:05:59	2008-08-18 13:10:15	3	2	86	0	121	150	3	176.40	30	42.87	CHANGED	PhsG.pphFthhhhslYsllsslllh....llsusl..hYhLs.ptappt+plhhsuulhlhlashsslsllslua.hlPpp.......................h.IESFu.h...................................................phssphhllhhoolllhluuhh.......................RssssFp..........t.hsps.u.htutsshYlh.hshElllsllYllsRlDLRFY	.............PhhG.pphhthhhhslYhhlsssllh....llsusV.thahL.s..psh.pth+sl..hhuush.lhlhuhhslsllsluh.hh...Ppc..............................lEpFu..h.......................................................................phpsphhllhhoohLlhlGAsh.......................RssssFt..........p.hsps.uhhps+ssaYlh.aslEllVshhYhluRlDhRFa....................	0	25	60	105
+11142	PF11310	DUF3113		Protein of unknown function (DUF3113)	Pollington J, Finn RD	anon	Pfam-B_4134 (release 23.0)	Family	This family of proteins has no known function. It has a highly conserved sequence.	25.00	25.00	56.30	56.30	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.00	0.72	-4.29	3	239	2009-01-15 18:05:59	2008-08-18 13:28:53	3	1	165	0	3	60	0	59.70	73	98.36	CHANGED	MQQQAYINATIDIRIPTEVEYpHFDDVDKEKEsLADYLaNNPDELLKYDNIsIRslslEV	..MQQQAYINATIDIRIPTEVEYpaasDVDKEKEsLADYLaNNPsELLcYDslpIRslslEV	0	3	3	3
+11143	PF11311	DUF3114		Protein of unknown function (DUF3114)	Pollington J, Finn RD	anon	Pfam-B_4178 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as cytosolic proteins. This cannot be confirmed.	25.00	25.00	26.20	25.10	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.77	0.70	-5.02	10	265	2009-01-15 18:05:59	2008-08-18 13:51:55	3	3	200	0	27	196	0	253.50	36	72.05	CHANGED	lGSstFppLWpttptpsss....KLLphlLshlcMPpELoG-LccsppL.....lscFSs-LuP+csFW+phuplVQpAFPsssLop...psp..lp++lHQFRYlISoQQAQaVRcHa+..ptGMTDupALApYLpt.............p+.sssYshhESARLHNKht...h..cssphl.YPDspsp.h.....NhKlLlsFHoEFILDppGpFLNplDs....................EthopNGllNGASFNYus.........+....NsspHtpLDVcPsphaDPtFRccshcu....F+SP..........p.pchphuahspKuhY	..........................................................................lGSssapplaphpthp.pt...........clL..hhthlth..cLuuplcppthL......lt+FusslsPcssFWc.huphVppAaPspphup...................spp...hs+plHQhRYhIspQphpa..lRsa....a+.....ppGt...TDtpALttYlp..................t..shchshtpSuRLHNKh......h........ptphh.aP-sts..h........NhKl.h..s...F..H.oEFILs.pp.GpFlsphDs.............................ps.......pppsllNGsSFNYus...............p..........N.scpHp.LDl.sPs........t.......haDsphR+psh+s....ahS.P..................chp...h..........................................................	0	1	9	19
+11144	PF11312	DUF3115		Protein of unknown function (DUF3115)	Pollington J, Finn RD	anon	Pfam-B_4191 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.10	21.10	21.50	21.60	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.06	0.70	-5.57	20	129	2009-01-15 18:05:59	2008-08-18 13:57:06	3	3	119	0	96	125	2	302.80	36	84.10	CHANGED	LF+ssFpspL....................................tusc.......LpphlQsVKucLYNRDahuAFss..--hhtAYAsRWSPSRALuYuolFssLt...........phhp.lssstss...................................................s+VLCIGGGAGuELVALAula.........stsppttustsus.................................lslslVDIADWSsVVc+Lssslpos.....................h..........pscsFslsFtcsDlLshsps........................phhslhps................hsLlTLhFThNELFops.hucThcFL.+LospscsGoLLLlV-SsGSYSclplG..................pK+aPhpFLlDphLlussssp.......sssWEhlpppDSpWaRh-tp.....tlcYslt....LENMRF.h+LYR	.....................................................h.t.h.....s.tp.......lpphlQtlKspLYsRDa.sAFss..pphhtAYAhRWSPuRALuYuulFtp..l............chht.htsstt....s............................................................................................................tpVlClGGGAuuElVALAuhh....................pph.st...tt.......................................................tlslshlDIAsWusVVppLssslpot..................h.............p....spphsspFtppDlLphspt........................phhtl.ht......................t.sLlTLhFThNELFops.hscThpFLhpLss...htsGslLLll-SsGSYSplslG..........................................p++aPhpFLlDphLlustttp................Wch.l..pp-ShWaRhstp..........LcYslt.........LENMRa.h+LYR....................	0	15	45	81
+11145	PF11313	DUF3116		Protein of unknown function (DUF3116)	Pollington J, Finn RD	anon	Pfam-B_4194 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Bacillales.	23.20	23.20	23.30	23.80	22.90	23.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.72	0.72	-4.37	6	124	2012-10-04 14:01:12	2008-08-18 14:10:29	3	1	42	0	3	60	0	84.90	44	97.09	CHANGED	ME+ssccLlhpVL.hs+sssssIpcLohphlphssspsaTKNELLhslYWLEhpGYlpRsppssppR.YohTtcGchLLp+lpsph	.............................MEcPscpLIhpVLphscsssssIccLol.E.hlpFsslssaTKNELLaslYWLEppGFIhRs..sps..s..p.....pR...Yo.hTpKGchLLp+lcp..l.....	0	3	3	3
+11146	PF11314	DUF3117		Protein of unknown function (DUF3117)	Pollington J, Finn RD	anon	Pfam-B_4211 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	52.10	52.00	21.10	20.00	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.65	0.72	-4.44	9	364	2009-01-15 18:05:59	2008-08-18 14:14:43	3	1	361	0	92	169	30	50.70	73	87.12	CHANGED	MKPRTGDGPhEVTKEGRGIlMRVPLEGGGRLVVElsssEAtpLussLssVs	.MKPRTGDGPhEsTKEGRG.IVMRVPlEGGGRLVVELssDEAstLGstLKsV.......	0	32	75	88
+11147	PF11315	Med30		Mediator complex subunit 30	Coggill P	anon	Pfam-B_28118 (release 23.0)	Domain	Med30 is a metazoan-specific subunit of Mediator, having no homologues in yeasts.	25.70	25.70	30.10	28.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.89	0.71	-4.08	6	107	2009-01-15 18:05:59	2008-08-18 14:37:18	3	4	82	0	74	96	0	135.60	50	66.20	CHANGED	NslsLsRlGQETVQDIloRhhEl...FthL+shQhssssTpppusup-+huKlQEphRol+lLF++L.RllY-+Cs-.s.sshp.sslEsLIPYtsEshsph-sp.hutph+hllQE+cEllE....pV+tKNcQL+cIlD+hR.hlW-INoM..LuMpRs	..................NssoLCRlGQETVQDIV.RThEl...FQ..hL+shQ...lPNG.sT.ppsshpDRhsKlQ-pLRplplLF++L.RLlY-KCNEss....uGh-......h..ssE..........p..LIPYh-E.sts.+p.-sc....u...Rh.sspE++E..lhE......pl+.KNpQLKpIhDphRp.lIW-INsM..LshR..................................................................	1	24	30	52
+11148	PF11316	Rhamno_transf	DUF3118;	Putative rhamnosyl transferase 	Pollington J, Finn RD, Eberhardt R	anon	Pfam-B_4218 (release 23.0)	Family	Most members of this family are uncharacterised, but one is a putative side-chain-rhamnosyl transferase [1].	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.40	0.70	-5.16	30	99	2012-10-03 05:28:31	2008-08-18 14:48:30	3	4	64	0	36	148	27	203.30	22	69.03	CHANGED	pllGLCRFSYsu....hG.GFp....assh.tcRtAhLYAPsRL-cRFphFEslsLPSLtuQTD.-FphlllhGcshPcta+sRLccLstshP...Qh+lhhpsPtp.pRpsh+csl.ptsppsssssslQFRlDDDDAlulDFVtRlRpsspsh.slh..sppsplulDFs+Galh.phssc.Glsht.thpsahssuLuhhhps.ssppolhsasHc+lhpphP.slohsstsMalRshpspNDSppphstp	.......................................hhh.hRFsh.......s..................ttp.thhhs.thlp...pRhtlFEphsLPSlttQTs...s....FphllhhssshPt.hpp+Lpplh..tshs...phpl.h.......h....hs...sht....pt...p.....hhpphh....tt.............hh.....s..sss.hhphR..lDsDDAluhcFltpl+pth.t.th......tppp.hslsaspGhhh...t.t...s.......h....h...hhshhhuhh..............tt.......shht.h..s.Htph.phhs......hh......p..t.....shalpshpt.Nssp.....h................................................................................	0	15	32	33
+11149	PF11317	DUF3119		Protein of unknown function (DUF3119)	Pollington J, Finn RD	anon	Pfam-B_4223 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	30.70	30.20	20.80	20.20	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.72	0.71	-4.06	23	112	2009-01-15 18:05:59	2008-08-18 15:54:12	3	1	99	0	51	110	104	120.40	40	74.53	CHANGED	VpLsPSaplPlllllhulsLLhl....sW...sulllulFGLFLLlQohoLRLcFTscsL.VaRuscplR...........RFPYs-WlsWRlFWshlPsLFYFRElpS.....IHFLPILFDsppLcppLcp+sss	...........................V.lpPsaplPllllhluhsLhh....lp........h.....sul.sl.uLhGLFLLhQosplRlpFsss.sL-VhpusphlR........................RFPYspWhNWclF.........Ws..hPlLhYF+EspS............................IHFLPIlFsscpLpspL.c+ss.........................	0	14	36	48
+11150	PF11318	DUF3120		Protein of unknown function (DUF3120)	Pollington J, Finn RD	anon	Pfam-B_4230 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	27.60	134.60	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.65	0.71	-4.09	22	71	2009-01-15 18:05:59	2008-08-19 09:01:02	3	1	71	0	28	77	136	201.10	47	85.40	CHANGED	AuhLVslPVFlQAPWVRhpPhuuhLhThlllsluh.Lthhpppp.hthhGsLLlGFShSWLAGslaWGWLRhcPlhHLPVEAlALPlAlsGLps+W.+lGssFYLuSLlGTAhTDlhhhlTGlMshW.pVlpAs..spA..s.lLppAutplhpPhulshlhhhAsllltluphhhptup....p.psWuhuuAVL.oTLlVDuLFLlsAll	.AuFLVslPVFlQAPhVRhhPhhSllhThshlhlu..lhLhpp.sc.pthWG-LLlGFShSWLAGulYWGWLRhcPlhHLPlEAluLPhAlhGL.tppW.+lGshFYLGSLlGTAlTDlYhaLoGLMsaWRQlhps-..ss.A..s.lLpsAltpltTPhuluhsllLuhlLlhlGhhshp.pp.......ptchWuhuGAVL.oTllVDuLFhluAh....	0	4	18	26
+11151	PF11319	DUF3121		Protein of unknown function (DUF3121)	Pollington J, Finn RD	anon	Pfam-B_4233 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as phospholipase proteins however this cannot be confirmed. Currently this family has no known function.	20.40	20.40	20.40	20.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.11	0.71	-4.78	17	451	2009-01-15 18:05:59	2008-08-19 09:15:55	3	4	419	0	48	252	42	169.90	40	71.10	CHANGED	hstsppCpp.supLpRLuCFDplhsTPhphsttt.t......psstWpRAhspEtpRsscsshhhhppst.....ssshllTs.....................sAlG..ss..p.PlLhlSClssIoRlpLhLscslpps+Vplsl......t.sshsp.Whsc-sGhlLcuGRGLPAIcplKphluuppLplco.sssslDsLpFDhssLspulcPL	...................................................................................l.pthpsCRpEsusLERLsCYD+lh..s.P...hpssshssuhst..........................hutuWpRAhppE.p.cRpuss.s.tlLlTps.Gc...tsollITo.....................PAlG.....psss+.PV.LhhSClDNITRhpl.....AL...+..s..l..c..s....pcIsV..ol......cpRslcspWh..l.R.-sGsLL-SuRGLsuI-pIKpLhuucpLhlco..sssuAspLTFslcGLscAlsPL.....................................................................	0	12	22	34
+11152	PF11320	DUF3122		Protein of unknown function (DUF3122)	Pollington J, Finn RD	anon	Pfam-B_4242 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	25.00	25.00	32.80	32.50	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.74	0.71	-4.24	21	64	2009-01-15 18:05:59	2008-08-19 09:22:56	3	1	59	0	24	73	130	133.00	37	78.06	CHANGED	Atl+ppppsssphhhR.....ShpoLRDhctpoWQllha+cscs....tpslpLRlVGFPGphclsHPpsLhlpsuppphhhs....ssshh..tpssssssuEaDLsslLspLspspPL+LpLP...sshspLsVPPaVVpEWppL	.........A.l+ppp-tsGphhh+.....ShpoLRD.chpoWQlVhaKcsps....spslsLRlVGaPGphclsHPpsLplpsuptphlhs....ssshh....tpsstsssupasLsslLspLspspPLcLpLP...uh.splsVPsaVVpEW+sl........	0	3	16	22
+11153	PF11321	DUF3123		Protein of unknown function (DUF3123)	Pollington J, Finn RD	anon	Pfam-B_4246 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	44.10	44.10	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.45	0.71	-3.79	4	54	2009-01-15 18:05:59	2008-08-19 09:36:50	3	1	4	0	31	42	0	100.10	64	58.26	CHANGED	VSVRTRVGKLsss...pRpLVLWLuAVVVSsA-..E..GaLsVlYKGsFP.-DPF+sVRV.ARc-sKhhsssAAsssuss.s.................st.susAP.RPTTAGKSltlLKt.h.Et	..........................VRVRT.VG+LGTo...sh+LVMWLGAVVVSDAD..D....GHLEVIYNGNFPRDDPFRTVRV.AVKDVKL.uPRPAPTPA...........................NhAAP..RPTTAGKsLPRLKMhhLE.................	0	0	4	16
+11154	PF11322	DUF3124		Protein of unknown function (DUF3124)	Pollington J, Finn RD	anon	Pfam-B_4248 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.40	20.40	20.60	99.30	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.44	0.71	-4.21	30	107	2009-01-15 18:05:59	2008-08-19 09:39:30	3	1	102	0	63	113	21	125.30	39	72.35	CHANGED	LspGpTlYVPlYSplYoss.....cppshsLssTLSlRNTc.spslhlsplcYaDTsG+Ll+pYlspPltLsPLuosclll-EcDssGGoGANFIVcWpuspslstPllEuVMIGstusQGlSFsopGpsI	.....h..GpolYVPlYSpIYpts......cppshsLosTLSlRNTs.spslhlsplcYYDosGchl+sYlcpPltLtPluohchhlscpDspGGoGANFlVcWpusptlspPllEuVMIus.tu.sQGlSFsopG+sI............	1	20	45	60
+11155	PF11323	DUF3125		Protein of unknown function (DUF3125)	Pollington J, Finn RD	anon	Pfam-B_4250 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Staphylococcus.	19.20	19.20	19.20	19.40	18.60	18.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.75	0.72	-4.18	5	369	2009-01-15 18:05:59	2008-08-19 09:44:08	3	3	69	0	3	125	0	40.30	58	77.09	CHANGED	MIFSQNLFRRPTPThIVCRNWESNFSLLGP+.QLAp.scasF..chhLlauP	...........MIFSQNLFRpPTPs..hhTRIEK..SLLQAHF+SVNYCQYNFlccpTLIasP........	0	2	2	3
+11156	PF11324	DUF3126		Protein of unknown function (DUF3126)	Pollington J, Finn RD	anon	Pfam-B_4268 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Alphaproteobacteria.	25.00	25.00	29.60	48.30	24.40	19.00	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.71	0.72	-4.30	18	204	2009-01-15 18:05:59	2008-08-19 10:47:42	3	2	195	0	74	130	111	62.70	53	85.20	CHANGED	ElcKL-sYL+cpFtssplpVpsRP+psDSAEVYlG-EFIGVla+D--EGEhSYsFpMsILDlD	.....El+KL-AYhKRsFsNsclpVcARP+K.sDSAElYlu-....EFlGlla+D---G-lSYsFsMAILDhD...	0	22	45	55
+11157	PF11325	DUF3127		Domain of unknown function (DUF3127)	Pollington J, Finn RD	anon	Pfam-B_4273 (release 23.0)	Domain	This bacterial family of proteins has no known function. However, it does show distant similarity to Pfam:PF00436, with proteins such as Swiss:D1W984 being similar to both families. This suggests that this family may have a DNA-binding function.	20.90	20.90	20.90	21.00	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.80	0.72	-3.97	29	271	2012-10-03 20:18:03	2008-08-19 10:48:04	3	1	225	0	71	260	272	86.50	36	67.45	CHANGED	ElpGK.Iplls-ppshGp.sG..a+KpEhVlc.....TcsQYPpclplphhp.DKssh.sshp.sGpclcVuhslcuREas........s+aFsslpu..W+l-	............ElpGKlItllssppus.op.sG...a+ppEaVlE.........Tc-QYPp+lsh.....-hhs.DKlsp...slp.hG-clpVSFslcuREWs........s+aFNolpA..W+l-....................	0	28	57	70
+11158	PF11326	DUF3128		Protein of unknown function (DUF3128)	Pollington J, Finn RD	anon	Pfam-B_4309 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.20	21.20	21.20	21.20	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.12	0.72	-3.86	24	194	2009-01-15 18:05:59	2008-08-19 11:52:37	3	1	184	0	150	191	0	86.90	29	48.69	CHANGED	hPs.....shSChpAFDphhhCa...................olGGQh+shYRYGphssCscphccFhaClpppo.....................cspclpEha+cchhpp.........ptpsSSEDlWchR	........................p.phSCtpsFDthhhCh...................ShsuQhpshYRYGchc..sCspphsDahhChch+s..h.........................................+tptlp-ha+c.+thpt.........pttssS-DlWchR........................................................	0	41	82	124
+11159	PF11327	DUF3129		Protein of unknown function (DUF3129)	Pollington J, Finn RD	anon	Pfam-B_4316 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	25.00	28.20	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.35	0.71	-4.46	23	214	2009-01-15 18:05:59	2008-08-19 11:59:31	3	3	57	0	193	217	0	197.00	32	62.76	CHANGED	VsAHGslhsspGssGusss.uLulssuo...............................PRDssst.sssQtDToIhRstch.sstusshGRT.uuGsscsupsspthM...........................................................................................................uussLPpl.osGGslphThHQVNsDGAGPaos.lDsTusGs..tsapphpVTpslPGhs.t.....................................................................uhopupspDFPlsVphPushoCTGTVuGtpNVClVRspNsAtAGPFG	....................................................................................................................................tuHuslhss..pG.....s...sG..s..s.hs..ululs..ss..s...............................sRss.sp.....sshQtDoslh+ptph............s.sts......s.....s.hG+T..t.s...G..sh...s..h..sphspshh..........................................................................................................................sssslPpl.ss..sGp..lshT.hH..........QVN..t...DGA.GP..asCtlDsousGs....sap..shp..Vs.p.sl..PGts......................................................................shs.....t...u...p.sp-a.slplphPsshsCsGs.su...G....p......N....VClVRspN........sAhu.GPFG...................................................	0	84	133	176
+11160	PF11328	DUF3130		Protein of unknown function (DUF3130	Pollington J, Finn RD	anon	Pfam-B_4322 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.60	20.60	20.60	21.80	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.96	0.72	-3.94	2	128	2009-01-15 18:05:59	2008-08-19 13:10:10	3	1	49	0	2	91	1	82.80	54	94.66	CHANGED	MpEIKVcEcThppauochtppupu.sYLPhKsGNMAaSRANSIsQLRoALh-LV-sVEsFQhVscpDAoRLKphG.uaAhpDphhtphhs	.MpEIKVpEsThppHATKLtScusu.pYLPhKsGNMAYSpAN..SIsphRoALh-LVDsV-sFQsVsppDAsRLKchGhuas+pDQthupchs............	0	2	2	2
+11161	PF11329	DUF3131		Protein of unknown function (DUF3131)	Pollington J, Finn RD	anon	Pfam-B_4335 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.30	20.30	20.30	20.60	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.14	0.70	-5.78	24	249	2009-01-15 18:05:59	2008-08-19 13:20:03	3	11	171	0	76	236	7	243.20	30	16.30	CHANGED	hphApsAWpYFcpNhp.spTGL....VNolss...asosTMWDhuSalhALlAAccLslIsppEF-pRlp+hLssLuplPLhpspLPN+sYsTpTtphssYtspPst..lGWSAlDlGRLLlsLpllpppaPpasstlspllt+Wphsphlp.cGpLaGuphtps..thphhQ...EGR..lGY....EpYAApuapLaGhsshpAhph......tsa.p.hspl.GlslPhDsRcstph.ts.s.lso-PYlLpulEhGhD.st.............htthAcplapsQcpRacpTGhlTAhoEcslspuPYFlYssl..aupGpsWsoloc...sGpphsphp....slSoKuAFuhasLa.cssYocpLhptl.ppLhs..pcGaYpGhYEssutsscuhT.hNTNullLEuLhYptpGp	...................................h.phA+psW+YFtp.sp.tp.s.sL.........s.N...p.......ttpTo.hslGsYLhullAAR-hGhIshcEh.cRlptsLsoLs+hpha.pG.cL..phYpTpThp.......h.p....Ph.................h.SAlD.GpLhshL....hhlppt...............................................................................................................................................................................................................................................................................................................................................................................	0	16	35	58
+11162	PF11330	DUF3132		Protein of unknown function (DUF3132)	Pollington J, Finn RD	anon	Pfam-B_4348 (release 23.0)	Family	This viral family of proteins are 55kDa. No function is currently known.	19.70	19.70	20.50	268.50	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.63	0.71	-4.29	3	62	2009-01-15 18:05:59	2008-08-19 13:35:40	3	1	2	0	0	38	0	124.00	96	74.21	CHANGED	SSSHYFFSKNITPTSVERNFGGVAQLEVERAKLSFETFGNKFLLKDVFMFSDQSLGDNILSYTLLKEEGHIDGMRTAGDDVLLEKDGEVVMILDSRDEGRMWIKDDVWAEVTEHGSKSAREYCM	SSSHYFFSKNITPTSlERNFGGVAQLEVERAKLSFETFGNKFLLKDVFMFSDQSLGDNILSYTLLKEEGHIDGMRTAGDDVLLEKDGEVVMILDSRDEGRMWIKDDVWAEVTEHGSKSAREYCM	0	0	0	0
+11163	PF11331	DUF3133		Protein of unknown function (DUF3133)	Pollington J, Finn RD	anon	Pfam-B_4400 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.46	0.72	-4.39	13	112	2009-01-15 18:05:59	2008-08-19 13:43:25	3	2	20	0	70	97	2	45.10	40	5.96	CHANGED	uGGAPFlsCssChELLQlPpchhlsp+p.pp+lcCGuCSplLphSls	.......hGGAPFllCpsChcLLQl.Ptchhls.p+t.tp+lp...CGuCScllphsh.......	0	10	32	55
+11164	PF11332	DUF3134		Protein of unknown function (DUF3134)	Pollington J, Finn RD	anon	Pfam-B_4408 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	25.80	25.40	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.53	0.72	-3.84	16	82	2009-01-15 18:05:59	2008-08-19 13:50:37	3	1	74	0	34	81	101	72.70	40	82.45	CHANGED	NPuLpc.sRppPAsVlPl+pEssLLsWLcsoGRLlsc-.p-...c..osEEEElS-Lhus--sh.c..--ss--h	...NPuLpc.sRp-PAsVlPl+cEssLLsWLEsoGRLlsc..-pp-t....chsssEE..EElStLMut--sapsc.--ps-..........	0	5	23	32
+11165	PF11333	DUF3135		Protein of unknown function (DUF3135)	Pollington J, Finn RD	anon	Pfam-B_4409 (release 23.0)	Family	This family of proteins with unkown function appears to be restricted to Proteobacteria.	20.70	20.70	20.70	23.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.44	0.72	-3.82	23	146	2009-01-15 18:05:59	2008-08-19 13:53:26	3	1	145	0	36	92	4	80.70	49	70.31	CHANGED	ppLPsFD-LhtLAcssP-th-pl+cchscphIsssscphptRLcuhQh+IDthhp+sKNPhpsslhltphhpcphhchpp...sLs	........sLPsFDELstLAcccP-AF-Qh++-Ms-EMI.SAScsM.QpRLaAQQSHIDRVlup.CKNPsHsNVsLMpELppQhl+F+sAL.p..........	0	6	16	30
+11166	PF11334	DUF3136		Protein of unknown function (DUF3136)	Pollington J, Finn RD	anon	Pfam-B_4419 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	20.90	20.90	21.90	29.10	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.10	0.72	-4.55	15	46	2009-01-15 18:05:59	2008-08-19 14:02:40	3	1	27	0	17	48	116	63.50	56	84.37	CHANGED	LoIGELEAsYslYCKALRhLlt-G+s.pcIcRTlCWc+LppLHpSLPppY+SP-cLhthhQ+chp	.LTIGELEAGYPlYCKALRhLltcG+ohp-IcRTVCWs+LEoLpRsLPsRYKuPshLhsllpR-lp.........	0	1	6	12
+11167	PF11335	DUF3137		Protein of unknown function (DUF3137) 	Pollington J, Finn RD	anon	Pfam-B_4422 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	25.00	25.40	24.70	24.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.79	0.71	-4.51	34	227	2009-01-15 18:05:59	2008-08-19 14:23:45	3	1	152	0	68	230	31	142.20	21	43.07	CHANGED	hhTlFcGllhthshsKpFpupTllhpc.........sthhspltt.ttt.......p+lcL-sPpFEctF-VYosDQlpARYlLoPshME+lltLppph.....ssslphuFhs........sclhIslsspp......shFE..sslhpslsptpplpp.hhp-lpthhsIlcpLpLs	.............................................p..s.FpG.hhhhph....+p...hp...upshlhss...........tthhst.htshttth..........p+lchEs.s....pFpcpFpVausDplpARhlLoPshME.pLhplppph.....tsslphsFh.s........sclhlslsstp......shFp.......sslh...p....sl......s...p......p....tlpp......hhpclt.hhsllctLp..........................................	0	22	42	60
+11168	PF11336	DUF3138		Protein of unknown function (DUF3138)	Pollington J, Finn RD	anon	Pfam-B_4423 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	21.90	21.90	22.10	28.50	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.70	0.70	-6.32	4	54	2012-10-03 17:14:37	2008-08-19 14:28:28	3	2	46	0	17	61	7	491.40	62	97.68	CHANGED	MK+KhlsALlAhALPGhAs.....AuosAspI+ALQAQlssLQpQhsELpsu.LAApsu.......AAuG....QuuuAAAuusP.sD........ussshTpDDlsph+pQlANtpLKVDuLs-AAsTGPIAGLSVTGYlDPTYlaNRussTSuFQFhNH-.usYsYaNSTFGDVYLDIKKTFGVGPhAPSAEITlMPNRGsG.olhssu.GusGNNIlNTAVVsVPLSsTpTF.uGLhsSFGGYEVQQSNQMLTLTHsLLYDFSDPGShIGs.GhNa..spssWAWKFllGNEQaRTtGulspTGsNA.hGpP.TpSNpsPTFTARVDYshSSALDlGGShNlGRQTLhSusspAGG...YGhtssuuuPYGsaFFsEADATYTLuDhQYNAElDYGQQQ+uAaNGGpAQWYGlSLLuHRKasssslGRMGATLRYDaLsNsKNGGGGuuIuLsusG....hDsssGFGIDssCLAsSpANGs...ECKGAsR.AlshDLLFYPTQQlTVKlEYRHDWAsptVFLRsDGSYuKSNDLLusQhIYoF	.........................MKKKLICLLVAGALPGhAh......AuSTSApIKALQAQlsALQtQhKthpst.LAup.u..............uA...suGAtutss..u..sAsuAsP.ss.............G+ApAsLTsD-VopMKQQIAN.QQLKVDuLTDAAsTGPlA.GLSVTGYIDPTYlYNRAAGTSSFLFANH..E.......s.......s.....YNYFNS...TFGDLYLDIKKTFGVGPMAPSAEITLMPNRGNGITLLQNSRGsIGsNlLNTAVVNVPloA..oT.T.LVAGLlPSFGGYEVQQSNQMLTLTHNLLYDFSDPGSYlGh.GsNY..TKGsWAWKFhLGNEQYRTYGSVTQTGTNA.LGDPITTSNKVPTFTARsDYTWS..SALDlGGShNIGRQTLs.SAh..stssus.....YGsGGtAsSsYGsFFFuEADATYTLADlQYNAElDYGQQQHAAa....N...GG.h...AQWYGLSLLAHRKFNsPVlGRMGsTLRYDhLsNsKNGGG..GGGI.AL.NGNG....MD.s.usG...FGlDADCLAsSKANGGLGFEC.KGAsRQDVALDLLFYPTQQITVKVEYRHDWANNKVF.LR.NDG.S.......YuKSND..LLATQFIYSF........................	1	2	6	10
+11169	PF11337	DUF3139		Protein of unknown function (DUF3139)	Pollington J, Finn RD	anon	Pfam-B_4425 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.79	0.72	-3.70	12	437	2009-09-11 16:35:17	2008-08-19 14:32:33	3	3	346	0	28	180	0	81.70	40	65.70	CHANGED	MKKh.hhhhllhllllo....llluhhhaFsh...ptcpshchlssYlscptlppspl...Kphc.hphshKpG..haYttV.sFKD-PshpY.Yp	...............MKKhK.h.hhlIlllhIu........lllu.....h..saaF....uhcshpt+cs..lph..lDs.....YL.p.-.Ks.lK.ccI...Ko..cK....spYSsKcG.....ha..YpcV.sFKDEPs.lTYshp............................................	0	12	19	25
+11170	PF11338	DUF3140		Protein of unknown function (DUF3140)	Pollington J, Finn RD	anon	Pfam-B_4435 (release 23.0)	Family	Some members in this family of proteins are annotated as DNA binding proteins. No function is currently known.	25.00	25.00	27.50	27.10	21.70	20.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.09	0.72	-3.87	24	152	2009-01-15 18:05:59	2008-08-19 15:01:41	3	3	123	0	77	151	3	90.50	41	67.61	CHANGED	-Fp-lVNMospELccWLcT-cSpSsGpspc....GEosGHpSGRRIV-ILc....Kc+sDLoD-Dh-HM++VVuYl+RHLuQ.....pPcuc..hpcocWRaSLM	......-FpchVNMTssELccWLcoccSpssGppptt.........uEosGHcSGR+IlcILc....K++sDLo--DhcHMRKVVuYl+RHlAQ........cPsss....sp..cocWRaSLM..............	0	26	49	63
+11171	PF11339	DUF3141		Protein of unknown function (DUF3141)	Pollington J, Finn RD	anon	Pfam-B_4443 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	29.70	29.70	29.70	29.70	29.60	29.60	hmmbuild  -o /dev/null HMM SEED	581	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.94	0.70	-6.18	28	171	2012-10-03 11:45:05	2008-08-19 15:06:39	3	4	134	0	86	231	61	521.50	42	76.93	CHANGED	DAhQRolLahDlhRpRGspah-HptpshPsVLtFcaEllhDGRcLP+PVNYuLlRIlPPss........hssDs...sK.RPFVVlDPRAGHGPGIGGFKsDSEIGlAL+AGHPCYFluFhPcP.PGQTlEDVs+AEutFlccVtchHPcus.KPsVIGNCQAGWAlhhlAAhpP-LhGPIllAGAPLSYWAGh....pGcNPMRYuGGLLGGoWlouLsSDLGsG+FDGAWLVQNFEsLNPANTLWsK.YsLYuclDTEusRaL-FERWWGGahhLNstEhpaIVDNLFlGN+LusGclhsuDG.pplDLRNIRSPIlVFsSaGDNITPPQQALsWIsDLYsss--I+upsQTIVYslH-slGHLGIFVSuuVA+KEHsEhsuslDhIDlLPPGLYEhsIs-ttssssssphh.spYhlchctRpl-DItu.hscssc-DERtFssVARlSElNhslYcpFlpPaV+AhsTs.sAchhRphHPhRlphphaSDpNPhhshlsshApplRpsRpPVusDNPFlphQpthSctl.puLDtaRDhRDshtEphFhslYuuPhlpALsGhpttpcs.t+......s.ss-cRphhphchtplpssl	..................................................................................................................DshQRulLahDshRpRGsphhpH.ttshPslLpFphEhlhDGRph.+PsNYuLlRIh...ssts.....................h.h.Ds.........tK.RPalllDPRAGHGPGIGGFKt.DSElGhAL+.s.G..H.PsYFl..sFhPpP.PGQ..Tlt..DVhpActtFlccVtt...hH..P..ps...+Ps.l..lGNCQuGWtlhhlAAhpP-.lsGPlllsGuPlSYWAG.....pGpN.PMRYsGGLhGGo..W.h...s...t...Ls.uD....L.....Gs.....G+FDGAaLVpNFEsLNPusshWsKhYsLYupl....Do..E..s..t..RaLc....FERWWGGahhLstp.EhphIV-NLFlGN+LspGplhh.......ssG.pplDLRsI+uPIllFsShGDNITPPp..QAL...sWIsDlYtssp-ltstsQ.pIVYhhHpplGHLGIFVSupVA++EHpphhsslchI-hLsPGLYEhplsp.ss........ssspt.p..........pahlphctRpl-Dlpt.....t.ps-phFtsVtplS-hN.thYctahpPhlpuhsss.sAchhcthHPhRhph.hhS.c.t.NPhht.lt.hAp.lRt..pRp.sss....tcNPa.hthpphhup.lttuL-haRchRDshhEthFhslYus.shht.hh.........................................h...........................................................................................	0	21	45	70
+11172	PF11340	DUF3142		Protein of unknown function (DUF3142)	Pollington J, Finn RD	anon	Pfam-B_4454 (release 23.0)	Family	This bacterial family of proteins has no known function.	30.00	30.00	30.50	30.00	28.80	28.20	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.33	0.71	-4.62	16	151	2009-01-15 18:05:59	2008-08-19 15:13:56	3	1	145	0	46	134	20	188.10	38	62.79	CHANGED	ssuR.hhu.sVhLssphps..Lchs-plhppllp.ltcWQupGsplsGlQIDFDAsot+LssYstFLccLRppLPtphtLSITuLhsWssou-...LssLhs.VDElVlQsa......pGhashsthtpal.pls+ls.lPF+lGLsphG.............Eh-sshp..............ppLhssP......................WFR..............................................................shslaLhNs	.............................s.ssR.shs.slhlssRhsp..Lchssplhttllph.hpcWpsuGsplsGlQIDFDAsTt+LscYssFLcpLRppLP..............s.shtLSITGLhDWspous...LssLht.lDElVlQsa...............QG.htsssphtpYLstlspLp....lPF+luLsphG.....................Eh-s.h...............p.LtssP..htthh..l........................................................................................t.......................................................................	0	4	16	28
+11173	PF11341	DUF3143		Protein of unknown function (DUF3143)	Pollington J, Finn RD	anon	Pfam-B_4460 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	28.70	69.00	22.20	16.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.08	0.72	-4.09	23	90	2009-01-15 18:05:59	2008-08-19 15:17:38	3	1	85	0	41	88	79	64.50	43	57.69	CHANGED	lGsp+ssp-.ssWtlppPsWsAplhL-pE-LtVpatpsG.....pcppRuFsYuLSRpDVEsAlhuG	.LGspQspp-hssWhlc+PsWpApL.LDh--LtVpYhpuG.t..tp-hpRsFpYuLSRpDlEsAlhuG.	0	6	26	37
+11174	PF11342	DUF3144		Protein of unknown function (DUF3144)	Pollington J, Finn RD	anon	Pfam-B_4465 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	25.40	25.10	21.60	21.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.52	0.72	-3.91	20	130	2009-01-15 18:05:59	2008-08-19 15:19:34	3	1	113	0	41	104	45	79.40	41	72.66	CHANGED	sFachADpFIpLANcpsppp..c.......sGcVuuuhhaAAARFNAahuussststsphts-K-pAlcaFsspY+cMLc-NL-Dal	.....Fa-RADpFIpLANphspst..c.........hGpVuA.AhhaAuARFNuahAAtshtpts-htscK-pslcaasppappMLp-NlD-Yh............	0	5	20	31
+11175	PF11343	DUF3145		Protein of unknown function (DUF3145)	Pollington J, Finn RD	anon	Pfam-B_4467 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Actinobacteria.	25.00	25.00	27.00	26.40	20.10	20.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.94	0.71	-4.83	17	330	2009-09-10 15:28:37	2008-08-19 15:23:36	3	1	327	0	91	220	102	153.90	50	92.65	CHANGED	VLaVHSAPsALCPHlEWAluusLuttVsLcWosQPstsGshRAEhsWpGs.sGouApLASuLRGWptLRaEVTE-sosGsDGtRasaTPsLGlFaAsTsssGslllsEsRLRshhp.utt....ssh-lt.cElchsLGpAWD-ELEsFRaAG-..GAsVpWL.+pV	.............VlalHSuPsALCPHlEWAluusL....sst........s....sLcWTsQPAtP.GphRAEssWsGs.VGTuupLAoALRuWphLRFEVTE-sosG.....s-GpRaSaTPsLGlapAshsssGsllVsEhRLRuhlstut.....sutpLssElsplLGpsWDsELEPYRtuGs..uu.VsWLpp.h......	0	33	74	87
+11176	PF11344	DUF3146		Protein of unknown function (DUF3146)	Pollington J, Finn RD	anon	Pfam-B_4468 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria.	22.00	22.00	22.00	71.70	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.61	0.72	-4.55	18	70	2009-01-15 18:05:59	2008-08-19 15:27:15	3	1	70	0	28	68	130	79.20	60	91.76	CHANGED	PpTTAalRVppQSasptpl-GEVpAGsFcWpFpWpFcpGc.LhVcPSLGRALIpDuLhRFLh+sDYpLEPGGDYsFTlRA+	.PpTTAalRlpcQSWppGplEGEVpAGsapWpFpWpFcpGc.LpVcPSLGRALIp-PLtRFLE+pDYpLEPGGDYpFTlRA+.	0	4	18	26
+11177	PF11345	DUF3147		Protein of unknown function (DUF3147)	Pollington J, Finn RD	anon	Pfam-B_4475 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	21.80	21.80	21.90	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.50	0.72	-4.04	11	537	2012-10-01 21:19:26	2008-08-19 15:39:40	3	2	300	0	60	163	5	109.80	44	87.60	CHANGED	hlL+FllGGhAVsluhIluphlsuK.hGGIFAsFPAVaLAAllhsGhpasupp....upplSpGAlsGMlusllClLsshhhltt.ptWthullhullsWFVuussIaplhph	.........................lh+FhlGGhAVhLu.IlusplshK....hGGIhAThPAVFLs.u.l.hhh.u.hpatsp..............uhpl.SpG..Alh.Ghhu.s.l..l.slhl.T.hhl+..t.+.ta..hhuh......Ihuhl.....sWFl.ulsIFphhch............	0	24	34	51
+11178	PF11346	DUF3149		Protein of unknown function (DUF3149)	Pollington J, Finn RD	anon	Pfam-B_4495 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.60	20.60	22.10	21.10	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.89	0.72	-4.40	14	230	2009-01-15 18:05:59	2008-08-19 16:01:56	3	2	230	0	48	142	6	38.60	43	21.33	CHANGED	chWhpL.FusslGLhShhVIhhslGlhuahsthFlhKhhpssp	.....hhhpL.FusslGL.SMlVIlsslGlhhaahuaFhYKhhp-pp..........	0	5	22	35
+11179	PF11347	DUF3148		Protein of unknown function (DUF3148)	Pollington J, Finn RD	anon	Pfam-B_4488 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	34.60	33.40	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.98	0.72	-4.36	23	92	2009-01-15 18:05:59	2008-08-19 16:04:34	3	2	88	0	41	92	86	62.20	48	59.37	CHANGED	slGspV+Lhst.PYLKTADPMPMLRP.PDLVslsE.GpVluh+PtshhuVRFcRGoFLlssphL	...lGspVpllthPPYLKTA-PMPMLRP.sDllplu-.GtllsR+PtshWuVRFs+GoFLl-upYl..	0	7	26	37
+11180	PF11348	DUF3150		Protein of unknown function (DUF3150)	Pollington J, Finn RD	anon	Pfam-B_4471 (release 23.0)	Family	This bacterial family of proteins with unknown function appears to be restricted to Proteobacteria.	23.50	23.50	23.70	25.50	23.30	23.40	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.42	0.70	-5.29	25	147	2009-01-15 18:05:59	2008-08-19 16:09:22	3	1	122	0	27	96	19	250.10	31	72.16	CHANGED	lLcsllllsLs.lslWoG+K+Lps.cDlth......splPPpplAoLGoK+lhDPcsLpsFsplKpcAp+hhpchGl+F..LG....GaAlPpccssplspcLcsIcscFtpt............KpsFLssY-ptlc-Whsp.s.sc.......auslI+ssss.stcplcpplsFsap..hhclpsss.......thscuLsppVsuLsspLhpElAppAcc...haccsht.........G+..pplop+sLss.L+slpsKlsuLuFlcP.plsslsphlcplLsslPc..sG.slcGsphhplhulls.hLscs	..............L-plllhcl-.hslWSGc++Lps.pDhphs....suplPPcclASLGSK+IsDPcsLpsFppLKpcApRLh.pphGlRF..hu....GaAVPps+h-plsscLscIpp-Ftpt............Kpp.FlssY-pslp-Whsc.p..Pc........auc.hIRpuh..sh-sVcpRlpFsat..hhphpPs............ttstsLsccVss..hucsLhpElAp-Apc...haccshs.............G+..splspps.lss.L+pl+-KlsuLoFlcp.chpPll-hlcphhsplPc....sG.slsss.htplhuhlhhhSD...................................................................................................................	0	10	19	22
+11181	PF11349	DUF3151		Protein of unknown function (DUF3151)	Pollington J, Finn RD	anon	Pfam-B_4506 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	25.00	25.00	37.00	36.80	23.80	18.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.63	0.71	-4.13	18	342	2009-01-15 18:05:59	2008-08-19 16:16:08	3	1	337	0	92	227	37	130.20	54	86.91	CHANGED	LhGPPPohLPs-ssApttLssGsss......ssVAAcHPsuSluWAt....LAEpALssG.............csVpAYAYARTGYHRGLDpLRRsGWKGaGPVPWuHEPNRGFLRuLuALu+AApsIGEs-EhsRCtphLcDuDPsAsspL	............................huPpPlhLPs...D...s...ssc.thhttupss......ssVAspHPouSluWAh....LAEsALts.s.................psVsAYAYARTGYHRGLDQLRcsGWKGaGPVPauHpPNpGhLRsltALA+AAptIGEsDEhsRCpshLcDs..sPpAhtsL......	0	29	70	88
+11182	PF11350	DUF3152		Protein of unknown function (DUF3152)	Pollington J, Finn RD	anon	Pfam-B_4512 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.10	25.10	25.30	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.34	0.71	-4.80	17	313	2012-10-03 04:41:15	2008-08-19 16:23:17	3	2	261	0	93	280	119	198.50	43	61.58	CHANGED	LssG.ushspsGsGTacsVsususplGpGt.+hapYhVEVEsGlsssu..sssuFAthV-tTLusP+uWo..pssphuFp+V-sus......PDFRlpLsSstTscphC...GhchthE.sSChs.......ssRVhlNpsRWlcGAhsFpGDluuYRQYlINHEVGHulGa.sHpsCstsGtLAPlMMQQThulss..................ss..CchNsWPaP	...........................................l..sssasptGssTacsV..s...u.s.s..sps..G....pGt..+lapYsVElEsGlssss...s.suFAphV-pTLss.P.+.uWs.........cssphuFpRlsuup......................PDFRIpLsSPs...Tsc..p..hC....GhchphE....sSChss.............ssRVhINtuRWl+GAss..F...p.G...D......luuYRQYl..INHEVGHul.G...a..sH-sCstsGtLAPVMMQQThulsst.....................c.....shhCp.NPWPYP.........................	0	28	67	89
+11183	PF11351	DUF3154		Protein of unknown function (DUF3154)	Pollington J, Finn RD	anon	Pfam-B_4516 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	24.80	24.80	25.40	24.80	24.60	23.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.63	0.71	-4.37	32	105	2009-01-15 18:05:59	2008-08-19 16:45:58	3	1	98	0	38	117	312	117.70	25	71.28	CHANGED	ssltcss-sFhsNsEptuttptphpptulpQhutEFts...tuhacphhsulNRlP...........RPshuhushuLhlhA.hhcPlhFustMtuhul.............VPEPLWWLhGslVuFYFGAR..p.sKspshp	...................................................sltphh-hhh..ss-.ttsttphphpt..tthppht.t...Ehth.....t.....sh.....hcphhstlNchs...............RPhluass.hul.......hlhu..hhsPlh.....hstthtuhsl......................lP.-.sL..ahLlu..ssl.hY.huu.R..p.tKtpt....................................................	0	13	27	33
+11184	PF11352	DUF3155		Protein of unknown function (DUF3155)	Pollington J, Finn RD	anon	Pfam-B_4534 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	21.00	21.00	24.00	109.80	19.40	18.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.75	0.72	-3.76	6	71	2009-01-15 18:05:59	2008-08-19 17:19:52	3	1	69	0	28	65	125	88.50	74	75.98	CHANGED	ARRRKRKSRRR.EGRRIL-hVPQYuIESGE-KPVTAAR+FIcupGItPPAlLlV+RNEHTTDRYFWAEKGLFGAQYVEENHFLFPSL+lL	............u+KRKRhSRRR.tGpRlLtpVPpasIEoGEcKPVTAAR+aItppGIhPPALLhV+RNEHTTDRaFWuEKGLFuAQYsEENHFLFPSLRh...	1	5	18	26
+11185	PF11353	DUF3153		Protein of unknown function (DUF3153)	Pollington J, Finn RD	anon	Pfam-B_4513 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Cyanobacteria. Some members are annotated as membrane proteins however this cannot be confirmed.	20.80	20.80	21.10	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.28	0.70	-4.89	26	198	2009-01-15 18:05:59	2008-08-19 17:20:04	3	4	196	0	50	139	128	206.20	24	80.70	CHANGED	lh.lllhLolLLoGCVchcsslshsu.c......+lpLuhplsShosphh.PWppphcpph+phtsphp.....psspsch..plpssshsup-hpphhpphhsssup..........suuls.hsss................plplpcpNaLlulcppLplslDLcsLs.lss...........LsLplsLssshshpthptss.s.st.t.......pt.plsWpLpsGclNcL-hsh.........WhhS.LGlGullIllllhluhhLpth+hph	..................................................................................................................shlLhLl.LLoGCl+lcsolslsscc.................................tpIs...hs..h..........sh...s.S.....h..s..st.s..shtsshpp+.l..p..tts.hssc.......p.s.h...thp..hsh.....s..ht-.l.phh...hs.ssp..............sssls......................lslcpss.ll.h....LphchDL.pslss.ss......................-lphslshPht.spsh.....susp....t..................p...lpW....pLpPG.lsphpsp.........................................................s.................................................................................................................................	0	12	30	44
+11186	PF11354	DUF3156		Protein of unknown function (DUF3156)	Pollington J, Finn RD	anon	Pfam-B_4555 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	19.10	19.10	19.40	19.30	18.10	17.50	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.96	0.71	-4.86	12	216	2009-01-15 18:05:59	2008-08-19 17:21:06	3	1	212	0	21	130	0	157.70	53	85.54	CHANGED	psLuu..p-t.ut...puthhphssGlplclpERscppFLhHlVSscaplpsssshsspuph+l+psGWLRRpGlsstsppGss.t..tllstLp.s.PsLtpsLtsLDa+chslstc.....supWplslE.aGASEVVsRhPuaRRYlRLssEQRhhLhuuhhthpphLp	.....................RDLuGahCE+LoE...+SAlL+Lssh.spVhs+.ppKRLFMASIpSCEFcVcGsls..hPlpG+IRlHQsGWLKR.hPVlFsuuKuou....uLlsaLN.paPsLQQALSELDaRRFoLVlH.....c+cWhCSIEhaAASEVVC+MPPlRRYLRLEccQRlLLLSVlsMlsQAhs....	3	3	4	12
+11187	PF11355	DUF3157		Protein of unknown function (DUF3157)	Pollington J, Finn RD	anon	Pfam-B_4561 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	21.70	21.70	23.40	22.30	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.30	0.71	-5.02	15	126	2009-01-15 18:05:59	2008-08-20 09:00:52	3	2	125	0	23	84	4	187.60	46	94.64	CHANGED	h+shs..llALlLls.....soAhAA-......thlTLEsGtpVpL+DDFTWEYlhhcots.................p.ss.sstssssssusssssssPsss..........ssp..hTshslupsc.ltphuKuGlcVsLssupa-us.cLsLshslospSocsVlhVclclolas-sGplLcpcclplWpuIhRMP-TYLRttppccucslhl-ss-+spap...lslcIhElco	....................................................MKphlLlAsllsh......SsaAuE.......slpLcDGR.lpLNDDFTWpYV.pETps............................tpsophuPllhusPVls...........psT..GsolsVusc+PlhQLSDSGVDVlLuuspYEpG.pLtLoouITNQSSQSVItVcltlpV.DspGsh.ccpcVTlWQSIKRMAETYLRPppuhcGKslcLsls-puQYp...lpApIppI-T................................	1	2	4	14
+11188	PF11356	Pilus_PilP		Type IV pilus biogenesis	Pollington J, Finn RD	anon	Pfam-B_3750 (release 23.0)	Family	Type IV pili are required for auto-agglutination, twitching motility, biofilm formation, adherence and DNA uptake during transformation [1]. PilP is an inner membrane protein, required for pilus expression and transformation [1]. PilP interacts with PilQ which suggests that the two proteins may have coordinated activity in functions such as pilus extrusion/retraction [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.67	0.72	-3.75	91	1330	2009-01-15 18:05:59	2008-08-20 10:47:43	3	3	966	2	259	918	191	88.20	22	37.51	CHANGED	lauphssttt..ss..............sssuspopLsl...pLhGll..ssssppuhAlIt..ssupppsatlG-plsG..ssplppltsD..+Vll.ppsGchcsL	.....................................................................................................sssssp.sphs.l...sLtGll....st...sppuhAlIp...psspQp...shthG-p.lsu..ssplppIptD....pVll.pppG+hpp..............	0	73	139	197
+11189	PF11357	Spy1		Cell cycle regulatory protein	Pollington J, Finn RD	anon	Pfam-B_3875 (release 23.0)	Family	Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events [1]. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27 [1]. Spy1 is also known as Ringo protein A.	25.00	25.00	29.30	25.60	19.50	23.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.65	0.71	-4.07	6	228	2009-01-15 18:05:59	2008-08-20 11:48:45	3	6	51	0	119	278	0	110.50	46	48.09	CHANGED	p-hpAFh+LLEDslVQcFLuhDpsh+lSDKYLLAMVlsYFpRAGLhstpYs+IpFFLALYLANDMEEDppssKp-IFsahLGKs.WpphhPpFLKLRcphaspMsaRAhVSRcpCEEl.AhsPpHWlWsRDR	........................pchpAF.+Lh-.D.sllpcFLhh....Dhsh+lu...DKYLLAMVh..sYFp.RAt....h...p.Yp+lpFFlALYLANsM.E.EDpptsK.pIF.ahhG................+..........s...+sph.s.FhKhR.phappMsaRAhVSpcphEEl.Ahs...PpHalWtR-R..................	0	37	40	55
+11190	PF11358	DUF3158		Protein of unknown function (DUF3158)	Pollington J, Finn RD	anon	Pfam-B_3964 (release 23.0)	Family	Some members in this family of proteins are annotated as integrase regulator R however this cannot be confirmed. This family of proteins with unknown function appear to be restricted to Proteobacteria.	21.10	21.10	21.70	21.30	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.98	0.71	-4.74	14	141	2009-01-15 18:05:59	2008-08-20 11:49:37	3	1	114	0	44	138	10	148.80	45	91.21	CHANGED	FpsLpQssFppLp+uA....sLKGLLpPFKGKGsL-thApQCpsLRssLhsLAp.plLsQspphPFs.LLsVcLsp.QsTuAGTTFLRWR.....phDputMGVulWppllssstTPssLlcDLauhEhQRIsLNMQISLlHoluRQAt-CAsKhApAEssYhpRhtthsss	..........psLppssa.pLpHuu....sLKGLLKPF..KGKGphpthAppCtuhR-tLhsLAp..plLtQ.AptaPap..LLPlcLsp.QsTuAG...TsFLR........WR.....phspspMGVulWpplhsss......pTP.sLlp-LauhEhQRIsLNMQISLlHoluRQAtECApKhupA-ssahpRhtt...s...................................	0	5	21	34
+11191	PF11359	gpUL132		Glycoprotein UL132	Pollington J, Finn RD	anon	Pfam-B_4015 (release 23.0)	Family	Glycoprotein UL132 is a low-abundance structural component of Human cytomegalovirus (HCMV) [1]. The function of this protein is not fully understood.	24.40	24.40	24.90	33.70	22.80	24.30	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.57	0.70	-5.03	3	84	2009-01-15 18:05:59	2008-08-20 12:50:24	3	1	12	0	0	73	0	190.80	78	86.68	CHANGED	MTSSTssPooTsoosTVToATSsssosSTNlTTAa-uSTpsc.ss.lpclLuIllYCVoGoSILSFLlVLlAVLYSSCp++PGRha+FoD-EuApLLD.sDDsGupo.h...GuGSRRG.pIPAu.SSSShYQRL-stDaDE..-usSAAREoMc+DP-.NVIYF+KDGNLDTSFVNPNYG+GSPMTIESHuDDDEc..IRYYMSVYDELTASEMEEPScS.sWQIPKLlKVoTpPVTLKEPEY	......hTSSTsVPTSTSSRNoV-sATSSs.PTTuhNMTTsHESS..VH.ssRNDEIM...KVLAI...LFYIVTGTSIFSFIAVLIAVVYSSCCKHPGR.FRFA..DEEAVNLLDDTDDSGGSSPF...GtsSRRu.......ssSS.hpRLpspDapp..pptStscpp.ccDs-.N.VlYFcKcGNL.sSFVNPpYG+tSshhIESphsDsEp..I+YYhSlYDELsAptMt-PSpS..WpIPKlhKVuhp.VoL+-PEY.........................................................................................	0	0	0	0
+11192	PF11360	DUF3110		Protein of unknown function (DUF3110)	Pollington J, Finn RD	anon	Pfam-B_4086 (release 23.0)	Family	This family of proteins has no known function.	20.20	20.20	20.30	20.20	18.70	20.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.92	0.72	-4.17	25	139	2009-01-15 18:05:59	2008-08-20 13:01:11	3	4	125	0	55	137	647	85.00	34	47.06	CHANGED	VaVLLasAGo-sEGIHSLclsu.........cslVLMFEscDDApRYAsLLEAQDFPsP...oVEsl-c-EI-tFCpcAGY-sclVtuGFhPts..-RLLluPP-p	...............haVLlap.s.p.-sEGIa.olp.hss.........+stVLhFEscDDApRYssLL.EAp.Da..sss...sVptl-sc-ltphCppss.Yphplltts..........lhh.PPp........................	1	15	39	51
+11193	PF11361	DUF3159		Protein of unknown function (DUF3159)	Pollington J, Finn RD	anon	Pfam-B_4163 (release 23.0)	Family	Some members in this family of proteins with unknown function are annotated as membrane proteins however this cannot be confirmed. Currently this family of proteins has no known function.	25.20	25.20	25.20	25.70	24.30	25.10	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.03	0.71	-4.82	29	387	2009-01-15 18:05:59	2008-08-20 13:48:20	3	2	327	0	139	362	262	187.60	35	79.02	CHANGED	hGGhpGllcSslPsllFlss.s...........htsLhhulhuAlulAsllllhRLlpRcslpsAluGhhGVuluAhlAhhoGc........A+saFLhGIhhshsaullhhlSlllRhPllGhlhuh....lpucst........sWR.ccpthlRAashuThsWsslassRhlVQh.LYhu...spsu.........hLusARlsMGaPLhslulhVoahsl+putpt.	........hGGhpGllp.SsLPsllFVls..s...........s.tuLts..ulhsAluhAsll.hlhRLl++c.slp.s.A.luGhh..GVuls.Ahl..Aaho.G.p........A+saFLhGlhhshs...hullhhlSlllRhPllGllhuh.....lpup.st.................................sW.........R..ps......s...h...h...+A...ashAThsWshlFssRhlVQh.L.Y.u...spss.........hLGsAR...lsMGhPLhuLulhloahhl+ps...h.........................................................	0	44	101	127
+11194	PF11362	DUF3161		Protein of unknown function (DUF3161)	Pollington J, Finn RD	anon	Pfam-B_4173 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	25.40	26.20	23.00	23.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.01	0.72	-4.08	7	30	2009-01-15 18:05:59	2008-08-20 13:54:41	3	2	18	0	17	31	0	77.50	33	35.88	CHANGED	pchLpsslc.ssh.SssAhsctRuhlss.Nt.aKalt-+shp+GusVPVhIsEhhp-GLpspsQTt...s+KlsshhpYhppoaFc..llcVls	..........slp.stF.slssLh+tRu+lsslNhlaKhlh-.....+shp.K....Gu.......s.lPlhls-hhphGLpstuQTs....tKLssh......pahc..llpl.................	0	8	10	15
+11195	PF11363	DUF3164		Protein of unknown function (DUF3164)	Pollington J, Finn RD	anon	Pfam-B_4249 (release 23.0)	Family	This family of proteins has no known function.	23.70	23.70	23.80	25.60	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.01	0.71	-4.91	30	235	2009-01-15 18:05:59	2008-08-20 14:24:56	3	1	198	0	53	219	8	187.30	33	91.65	CHANGED	YhpDAcGpLlP.stlKslDph....RDchVpclVspActlppplscFKscsFsDluAFlsLSAccYus.+lGGpKGNlTLhSFDGpYKlphtls-plsFDEcLQAAKsLIDEClp-WopGucsEl+ullscAFpVDKpGplssu+lLuLRRlcIsDc..+WpcAMcAIuDSlpVsGSKsYlRhYER.ss..supapsIsLDlAs	..........................................ah.supGpLhP.t.l+shDth....cD-hVpclhspAttlpppltpFK.tpshs-lsuFlsL.A-cYus.ch..GGp..KGNlTLh..oaDGph+lphuht-plsFD-.c.l.ps.A.KsLI....D...-ClpcW.oc....G.u.c....s.c.l.psllppAFps...D.KpGplsssclLtLR+l..c..Ip...D...p...cWpcAMpAIs-ulpVssoKsYlRhacR.sp...sspap.IsLDlu............	0	16	37	45
+11196	PF11364	DUF3165		Protein of unknown function (DUF3165)	Pollington J, Finn RD	anon	Pfam-B_4331 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.00	25.00	27.50	27.00	23.50	22.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.88	0.72	-3.85	7	341	2009-09-10 15:00:51	2008-08-20 14:42:00	3	1	339	0	21	93	0	81.80	62	96.35	CHANGED	MhYLIluILllhaYlFhAPcSIKsThNhluhVhllshLllLhsLuhl+IhQhPsEhFlGluMllluYaAL+DIhphspcs+.	..MVYLllGILLLLLYlFATPcSIKGTVNIVuMVslLVALLILLVLSFLKIFQLPoEIFluIAMLlLAYFSlRDIoLMPlKKp+...	0	1	4	12
+11197	PF11365	DUF3166		Protein of unknown function (DUF3166)	Pollington J, Finn RD	anon	Pfam-B_4333 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.90	21.90	21.90	22.20	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.26	0.72	-3.53	4	340	2009-01-15 18:05:59	2008-08-20 14:45:14	3	3	45	0	193	276	0	94.50	47	14.45	CHANGED	EDsuDLRCQLQFs+EEuuLMRKKhAKlscEp-chcpELpKY+ShaGDlDS...huchsuGuPcosRpttLcLcLKhsc.puNhLutKlsEL-sENR..sh+	....Essu-L+ppLQFVcEEApLhR+phAcl-ccNcplpp...ELpK.Y+o..h...a.G.-lDu.....................sp....p.....t..u.u..ss..ss.......+p.s...t..L.p.cLKh...sc.phN.LStKlhcLphENR..hLp....................	0	20	34	85
+11199	PF11367	DUF3168		Protein of unknown function (DUF3168)	Pollington J, Finn RD	anon	Pfam-B_4337 (release 23.0)	Family	This family of proteins has no known function but is likely to be a component of bacteriophage.	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.80	0.71	-3.96	123	1027	2009-01-15 18:05:59	2008-08-20 15:06:50	3	4	854	1	179	692	99	112.10	16	88.23	CHANGED	slhttLtss.s...slssllss........la.....-tsP.......ts...s.....shPalslutspspst.ssh...ssts..t..phplplcl...a...u...pss.......tps.s..ppl....ssslpsAL................t.hthhthphttspsh..pcsssh.....hh+.....ss..lph	.........................................................ltthhss.........la........ch.hP........ps.......s....shPal.shs.h.p.s.hss..ssh...ssps..t..phtlplcVa.....u......pss....sps.h..ppl...tptltpsl..........................t.phh.tsh..p-.pt.......hh+h............................................	1	46	110	141
+11200	PF11368	DUF3169		Protein of unknown function (DUF3169)	Pollington J, Finn RD	anon	Pfam-B_4342 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.60	25.60	27.20	29.40	25.50	25.20	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.57	0.70	-5.17	11	562	2009-01-15 18:05:59	2008-08-20 15:09:01	3	1	550	0	31	240	2	235.20	36	99.32	CHANGED	MKpt+p......hhRhlhhlLluullGGllGhhsuth.......hpplshsshtslthlphlupllllllhshshhhhhpshKapphhppphD-Dtsc..ph.ppt.+phphuoIlhslshllshlsllls..hllshhsssss...Lhhslh.hlhhlhhlhhplhhhKhhphl+sh+hsthsshc.hcchhtuhDEuE+ptphcpuachhhslNthlL.slhllLhlluhhTs.splhulLllshIal.....Ylslthhhhs++aa	............................MK.............hLhalhhllLG.G....hlGhh..lGh.hhuph-.........cplhhs...sh.s..hsh..ISh......lshlI.hh.l...shh.l.shh.hh.+.+.uhKa+pLhp...c...Eh.D.-Dhs-..pY.lph.Rp......lth...GoIhhslps..lhh...hlslhI.....Vl.hh..tsssth...............hah....h....h...l...hhl...hhhhhphh..hhKh..t....h..p.c.hs.hhAs.c..scchlp.t.h.DEGERphpLptsF+hhht..s.hlL..hhhlhlh.lhSh.hT.G..Q.hhuh.L....Llh..AIal.....Y.shh.L.hs+Raa............................	0	4	12	24
+11201	PF11369	DUF3160		Protein of unknown function (DUF3160)	Pollington J, Finn RD	anon	Pfam-B_4384 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	38.00	34.70	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	631	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-12.86	0.70	-6.20	17	97	2009-01-15 18:05:59	2008-08-20 15:47:45	3	6	73	0	39	99	5	586.80	29	79.38	CHANGED	sLspsshshLp+NGFVVl.........ts..ssppcplsph........YcsLc.p.........slPlFIToDSlLHlYHIQFD-TL+plEcccFastLWclspsLLssSlcsYs.....suoGc...+EAARRNsAYFuVAhsLLp..Pc..pht........................tpaphElPuhV+p-VEAELsLI-AppGhshSPIF....p......YpE...DYSQYlPRGHYT+S-pLpsYF+AhMWaGRhShLLcss...........p....................stp.....-AplQTlp....AhLIosphc.pcpcLhccWcRlYslTAFYVGhSDDLGPYEYhcALcsVFGsp....tsshsspslpcL+scLtchcs...PcIYGGTGthh....hss-ttsppLcsTcGFRhMGQRahPDSYlhpsLl.........................s......RhaPpGLDlMulLGS-RAtphL.cphs..SsapsYstpappL-sEFsuhsst-WN+NLYWuhLYuL..pPLhpsassGYPTFMQTpAWpDKpLsTALASWTELRHDTILYAKQsYs....psushs.pE........psshGYVEPsP-FYsRhLALT+MTpsGLs-hclLDcpuc..........pchppLcshLp+LhpISpKELENKcLT-E-Y-aI+sFGpplpsh..............htsVDtcspposlVADVaTss.....tstVLEEGsGhlDhllVAYc.sDGRlhlusGPVhSYYEFhQPhu-RLTDEcWR-ML.pspsPE..+PEWs	.........................................stt.hthLtpNuFslh.........................s...p.pplhph........Yc.ptchp.....................phP.FlToD.hLchaHlhFDphL+plEcpphhstLhclsp...shhptp.hpphp.....p..pspp..hcpsAtpshs.aFulAhtLLp....................................p.plPtthppt...sptElph.Iput....ps...t.Sshh.s............hp-.....DYS.apPRGHYT+s-..pLppYF+uMMWhGphsFhhpsp......................................tphhp....Ahlls.phhp.....p.phhchWpplapshsFhhGpoDslshhchtphlppshstt.......h...hsppth.p......phh...tpl.tp..h.tt...spI.s................................p.ppstsaR....hMsQRah.Du.lhppLs...................................................ststt..RshP.pGLDl.hAshGocpAtplL.cph.t...ppap....pYptph.pplcpphtshstp.t.hppslYtsWlhsL....tsh.hpp......hs..pshPsFMpotsWppKpLsTuLuSWsEL+HDTILYuKQshs.......EhG.sss...t..............shGY..VEPssphap+hh.......sLsphstps.....Lp....p.....hsh......ls-ptp..........tphpplpphhphLhpIucKELp.sp..pLop--YchIp.h.Gs.pl-.h.................................hps.sts.spphslVADVhTss........ts..tlLc.GsGhstplhVsh..hsGpl..hlspGsVhSYYEFhpsh.s.c.RLTDEcWpchL....ptpsst.....hPtWh...............................	0	23	28	33
+11203	PF11371	DUF3172		Protein of unknown function (DUF3172)	Pollington J, Finn RD	anon	Pfam-B_4527 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	55.60	54.20	20.20	19.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.78	0.71	-4.68	10	83	2009-01-15 18:05:59	2008-08-21 09:45:08	3	2	78	0	41	83	146	136.60	53	66.78	CHANGED	FNhuTlA......lLGGVhVLGIGIGluhSSTsohsPpNVASpEhIDpuAPssElCVQaGASAhVhDhRlFlTLNPFsVaVoQPsMQPGCVLRRsNWslLEQcpLlou-QlR-CKsRMNTFGYsGsL-u.cPcIcClYQN-uApNLF	........hNhsTlAlLAGlhVLGIGlGhuhoSTsshsPpNlASp-hlDpusPsPElChQaGASAhVhDhRlFlTLNPFslaVoQPshQPGCVlRRsNW.ulLcp.ctlloscQlR-CKpRMNTFuasGsLcs.pPplcClYQs-supNhF..................	0	12	30	39
+11204	PF11372	DUF3173		Domain of unknown function (DUF3173)	Pollington J, Finn RD, Bateman A	anon	Pfam-B_4543 (release 23.0)	Domain	This family of proteins with unknown function appears to be restricted to Firmicutes. These proteins appear to be distantly related to HHH domains and are therefore likely to be DNA-binding.	25.00	25.00	25.20	29.10	21.60	24.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.66	0.72	-4.36	20	326	2012-10-03 02:11:09	2008-08-21 10:35:08	3	1	232	0	31	166	3	61.50	41	86.57	CHANGED	ptTlo+pDLIclGappppApsII+pAKplhVp.+..............GasaYsNKRLshVPsulVEE.lLGlpl	........tTlopcDLlpl.GaspppApcII+pAKplhVp.+..............GasaYss+RLshVPtplVEE.lLGlpl.................................	0	5	15	23
+11205	PF11373	DUF3175		Protein of unknown function (DUF3175)	Pollington J, Finn RD	anon	Pfam-B_4566 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	21.00	21.00	22.40	22.40	18.10	17.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.80	0.72	-3.96	14	130	2009-01-15 18:05:59	2008-08-21 10:43:47	3	2	128	0	55	117	6	83.60	60	71.96	CHANGED	+WSpcVTE+SsALDLEtsVFp.cDPccIAtSLKRSA-pScRRKuoPFpSAMSMLsFYINRAG+sLscspRpsLEcAK-ELRctFGR	...............+WSpcVTcpSD.ALDLEtslFcpcsPccIAtSLK+SA-cScRRKusPFQSAMSMLsFYINRAG+sLscsRRpsLEcAKccLRcsFGR.........	0	12	29	40
+11206	PF11374	DUF3176		Protein of unknown function (DUF3176)	Pollington J, Finn RD	anon	Pfam-B_4567 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	21.40	21.40	21.50	23.40	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.31	0.72	-4.19	34	177	2009-01-15 18:05:59	2008-08-21 10:46:33	3	4	49	0	146	180	1	104.10	27	17.65	CHANGED	llulLhhhcs+shss.Wsh...hloLNsllSlLoTlspushhhslupuluQLKWhaFp.ppp...p.......LsDhphhDsASRG.saGulh.lL.....hphps+.pluslGul....lhllu.luhsPFsQQllp	.........................lslLhhhcspslsp.Wsh.........hlohsslluhlsslspuslhhslupuluQhKWhhap...pt......p.......LtDhphhDpASRG..shGuhh.lL..........hphps....t...t........lusluul....l.hl....hs.hhhsPhhQphl.s...................	0	21	72	113
+11207	PF11375	DUF3177		Protein of unknown function (DUF3177)	Pollington J, Finn RD	anon	Pfam-B_4580 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	25.00	25.00	74.10	74.00	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.43	0.71	-4.85	22	74	2009-01-15 18:05:59	2008-08-21 10:54:46	3	1	72	0	29	77	136	186.90	44	95.59	CHANGED	hcsLVWLsYRLAshFslulPLlLLIWAhh++tsAl.RLLsIYW+VuSLLsIolhLhhsph............PlualouhlA.lLhslSl....WFWVDLNEELtDhPs.pPLsLsh+hWRWulTsaulluhhhshssLsCshshs....tss.CpsWLEsP.........lFchlFtushotuhhuFlGhluLlhYllsLlpalllRLP+QGRsAst	......psLlWhDYRLAllFslhlPLlLLIWuhhc+.culsRLLhIYW+VASLLhITlhLhlsth............slualouhhAplLIslSl....WFWVDLN-ElcDhss.psLtLshpsWRWAlThausluhlhplshLsCuhshs....sss.CplWL-sPh........hac.hFtushssuhhuFlGhluLllYllhLh.alllRLs+QGRsAh.t......	0	5	19	27
+11208	PF11376	DUF3179		Protein of unknown function (DUF3179)	Pollington J, Finn RD	anon	Pfam-B_4591 (release 23.0)	Family	This family of proteins has no known function.	19.30	19.30	23.00	22.10	18.70	17.50	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.62	0.70	-5.22	35	131	2009-01-15 18:05:59	2008-08-21 11:11:21	3	4	102	0	49	143	88	243.70	28	77.52	CHANGED	P+DGIPAls.....sPpFhssspssh..lcss-sVlslplsGp..sRAYPh+ILsWHEIVN.Dpl.uGtPluVTYCPLCsouhs.F-cplss..tslsFGVSGpLhNSshlMYDR....pT-ShWpQhhGpAlsGsh....sGppLcplPshhpoWspa+pcaP-u.hVLupssuapRsYup........sPYss.........YDsssp..h......lassthsscc..lssppcVlGl.shtst.thAashspltpts.....t.plsspslslsacsstsS.....................thhsups....................................pclsphssF..WFAWt.....A..FaP-osl	.....................ssIPuls.............pPpahs.stpsp...ltsp-.Vhsl.thsGp..s+AYPhphlhaHElVN..Dpl.ushslslTaCPLssouhs.a.cpph.ss.............t.hpFusoGhLhpushlhaDR....pTpShWpQhhGp..AlsGsh...........tGppLp.lP.shhpoWtpappt..aPcs.hVlsps......p..s.h..tRsYsp...........sPYts................Ytt.tt..............hhsst..spp..hsshphVlult.tt...th..........Aashstltptt.......plsttslhhhhpss.ts....................................h.................................................................................t.l..t...h..hFua........s..FhPps................................	0	16	36	49
+11209	PF11377	DUF3180		Protein of unknown function (DUF3180)	Pollington J, Finn RD	anon	Pfam-B_4592 (release 23.0)	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently there is no known function.	24.50	24.50	55.10	55.00	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.77	0.71	-4.31	30	431	2009-01-15 18:05:59	2008-08-21 11:16:20	3	1	428	0	112	293	37	137.30	29	82.88	CHANGED	LlusAlsuAlluall..lhtha.tshPs.lshhsuloLhllAllplhhAhhlRp+l.....husspptlcPltuARslsLAKAoAhsGAlluGhasGhhlalL.ptspltsuus-shsusluuluulALllAGLhLE+sC+lPs	...........lssslsuAsluahh..lhthh.sshPs.lPhhsslslhllAlsphhhAhtlRs+l...............hsssppt.lc.PhtuApsLsluKAuAhsGAllsGhahGhllhhl.tphplssstpcshsssluuluulAhssAGlaLEpsC+lP...	0	35	82	104
+11210	PF11378	DUF3181		Protein of unknown function (DUF3181)	Pollington J, Finn RD	anon	Pfam-B_4595 (release 23.0)	Family	This family of proteins has no known function.	19.70	19.70	20.70	27.90	18.40	17.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.92	0.72	-3.97	23	76	2009-01-15 18:05:59	2008-08-21 11:23:09	3	1	75	0	34	78	96	87.90	43	84.25	CHANGED	lccLsusIuD+lYlplupWHLYLGDAtLupsLA.Eshshl-pG..upsAAcpuL-ulpVslGGGpspLPLu+LlPsuQlp-LEEILEpa	..lcsLAupIG-plYIDlApWHLYLuDA.........+......LppsLAcchhshlpps...hscsslppsLcslpVtlGGG+pplPLh-LlPspphhcLh-lLEca..	0	7	23	32
+11211	PF11379	DUF3182		Protein of unknown function (DUF3182)	Pollington J, Finn RD	anon	Pfam-B_4440 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	26.00	26.00	26.70	44.20	25.40	25.90	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.98	0.70	-5.76	15	90	2009-09-11 05:33:34	2008-08-21 11:34:51	3	1	85	0	36	90	3	331.40	45	93.94	CHANGED	hVlspsscstssp..HEtsTpttLucplApLhGhpauGshc......sstptsu..sYlVPscTLVs.spAppLGlpuscDLaGGlVP+uFlATKAIoHsLspssAssPsGWopsFupplpssVLPGaosFShsDARpAut+LLtsGsVRlK.spusGGpGQpllcssspLDstLuuhssspLtspGLVLEccLcpspTaSVGQlpluGllsSYaGsQpLThsssGpcVYGGScLhVVRGua-ALLtLsLsspsRpAVppApsYDpAAttsY...PuhhASRRNYDVA....pGhDupGtsR..sGVLEQSWRlGGASuAElAALcuFppDPslptVpAuT+ElYG.-stlPssApllYRGsDspsG.LoKYsp	............h.Vlsasscsts..sp..HEhtspttlAcplApLhGhpauGthc........sshttsu..hYhVPscTLss.tpAtpLGlpuspDLhGGlVPHuFlATKuIsHPLstss.ussPtGWsttFAppltsslLsGaosFShsDAppAutpLLt.pGsVRlK.spusGGpGQhllpDhspL-thLsuhs-ptLtppGlVLEcsLppshTaSVGQlplsGhhhSYaGsQp.TtsspGpcVYGGScLhVsRGuapsLhsl.sLsp.thRtAlppAphaDpAsttsa...PuhhASRRNYDlA.......pGhDupGt.+..sGVLEQSWRlGGASuAElAALpAFttDPuLptV+AuohElYt.s..hPssAplhY+GsDspsG.lhKYh..........	0	4	13	24
+11212	PF11380	DUF3184		Protein of unknown function (DUF3184)	Pollington J, Finn RD	anon	Pfam-B_4192 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	19.30	19.30	19.30	19.30	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	691	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.37	0.70	-13.36	0.70	-6.59	4	258	2009-01-15 18:05:59	2008-08-21 11:50:57	3	9	118	0	96	260	13	177.60	23	32.61	CHANGED	lssR....DRETDELRHSLRSVEQHVRWHRGRVVhVSPGHHPsWVDGAKNFLAGhCGuARVQALRSSGTHLRVTTVHQDAVMPYuhRLTVDSHsIEQpLWRVRNhTsVHVYMNDDYFVNRDVAITDLhNEYGGTIVRTE+GhltcGhpGssS.uoWsEGVtNTpLFNhhELDlpHEDaLPcsLl+pWpp......t.sQ.sspulhp.....hpc.lPs.............................luhschlssA....aspsshSpP..PTuhP+.R.R.....aYATHAPFVYCTNMaRaLssRYptEhAtsphp+RtRSApDLaVPFlYNAFIMARPWQASP+FLPYLhpL+puh+ttcscAh............................s..sPPhp...............IhL-N-DGCAPATLhts..ASEslauKFssNlctNcchlccVppssPLaFNINAGFooscAADQLRcFLHGhFPTPVYLE......................oSuuGsA...pptsLSRLFGDLMALPVVsVVSYEEGVCPLVRSLALAFAGHHRGGV+VpV-p+G....sAsLtEsRtsLsHRVhSAMPssACTYtcpVoVcsutRGESlAElARRAhsth....tGGVELPuTCGuGGAGLRVRGFVVDARTRusPlRSssALhcALAVPAQTLSLEDFRAVAVGPSEtDVVLVVSREDA-AKAVHWVNGASESDLLlTYPLPVEAYEDMsAEVRWS	............................................................ts...............................................................................................................................t..h...s..............Th.sS.sIE..lapl..shst.alYhNDDhhh.p.l..tphh........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t................................................................................................................................	0	54	64	83
+11213	PF11381	DUF3185		Protein of unknown function (DUF3185)	Pollington J, Finn RD	anon	Pfam-B_4606 (release 23.0)	Family	Some members in this bacterial family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently no function is known.	21.40	21.40	21.70	25.70	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.83	0.72	-4.21	19	111	2012-10-03 00:20:40	2008-08-21 13:37:02	3	2	105	0	46	85	6	58.90	45	81.59	CHANGED	KllGlsLllsGlsLhhaGaphhsShuSphochhTGssTccshhhhlGGsVusllGlhhl	..+hIulALlVuGlVLLYFGh....QuacSlsssloRhFT........GoPo..sKTlhllsGGsVAsllGLhtl.....	1	13	27	37
+11214	PF11382	DUF3186		Protein of unknown function (DUF3186)	Pollington J, Finn RD	anon	Pfam-B_4607 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.30	24.30	24.40	24.70	23.60	24.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.82	0.70	-5.29	25	294	2009-09-11 00:08:05	2008-08-21 14:08:03	3	3	288	0	100	240	10	292.40	28	96.48	CHANGED	MIshRaHllSlsAlFlALAlGlllGssh............LpsslhssLpschspLcpctspLpsptpslpppssss-satstlsstllsspLsu+sVsllphssusssssculpchLppAGAsVsuplsLp-pah..sssss-clpolsss.hhssustlsptss-sus...sthlu.slh.s........stssss-csslLssLpcss..hls..hp...sssshsusssllls.......Gsssss...tsssttstslschspuLsstGtus.....Vl...sGtptousssuhluhhRu....tssVSTVDslDsshGclsshLALtptl.sGt.sGpYGsussAsulhPs	.................hIshR.HslSlsAlFLALAlGllLGush............hssslhssL...p...pphp.s..LppphspLps.ptsth.ppplssucsa.sppluspllpssLsu+sVsllph.ss.uscsDhsulschltp..AGuslsuplsLs.ppFh...sssps-pLpsllss.hhPs..GspLssphh.-tus.s..Gph..Lu.sLh.s...................................stsspspcsslLssLp..-sG...als....ap........ssthtsAsssVlls............Gss.ss........sssttstslschutuLsstus..us...................ll...sGp.t.ou.spsu....hlushRu.........sstlSTVDslDpt..sGplsshLALtp.l..sGt..sGpYGsutsApulss.................................................................	0	46	80	94
+11215	PF11383	DUF3187		Protein of unknown function (DUF3187)	Pollington J, Finn RD	anon	Pfam-B_4660 (release 23.0)	Domain	This family of proteins with unknown function appear to be restricted to Proteobacteria. These proteins are likely to be outer membrane proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.90	0.70	-5.31	18	149	2012-10-03 17:14:37	2008-08-21 14:09:55	3	2	139	0	32	161	75	297.70	39	89.81	CHANGED	hhhllhhhsshss.sssssshshuPhhshsQoPlpshtLoPpLRSuhsLssuphEhhhotohASlWu....po-phhhDY.psphsluhcaphssphplclphpahhtusspLDuhlpsFHDhFGlsQsGRscssccpaplph..s.ptGhphpsFpGcol.tuulolh....lpaplhpstpc..ulSlGuoLhasssssupFpss.uh-.ulplsauhpts.pash.......auslGhsahssspshhs....h+stshthuhGhcaphhspasLlsphchapGhh-ss..schucsSsElshGaRYhh.pssAlElullENlhNhDNSsDluFplGhRaph	....................................................................................................h...h.hhhhhhshsshssphpaGPhhsYAQuPltutuLoPpLRsGFoLP.sp.Elauuh.ohASlWu.........cossYthDaYpNQhslGl+WQhsscWQhELsYRas.AhsNpLDulThuFHDhFGlsQNGRDpVc+cRFpIsh..P.cptlthcDFsGsTL.suuholY....spYQlasscpH.....GLSL..Gu..oLYYNp..sGhhchs.....pFE..QuLQLNYoYpp..s....sHpl....auhlGl.s.a.+sssss..s....lsh+.cs...oh...s...husGYcYplsspH.pLhspa+..a.Y..QGss.-us....pEhp...cs...us.Ehl..L.GYRYhh.ssSALEluls....ENl.hssDNSTDIAhpluYRa+....................................................	0	10	20	27
+11216	PF11384	DUF3188		Protein of unknown function (DUF3188)	Pollington J, Finn RD	anon	Pfam-B_4573 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.60	24.60	25.00	24.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.14	0.72	-4.39	33	165	2009-01-15 18:05:59	2008-08-21 14:10:22	3	1	164	0	20	53	76	50.00	44	76.71	CHANGED	luAPhLIhlul.luhh...pRpGsD+ltulPsllsGh..uLllpusVsRth+R++	..NuLFLsSIGhlIlLa...ohsspsthhsL.uLsTGl..hllslGshhhh+t+K..........	0	5	9	17
+11217	PF11385	DUF3189		Protein of unknown function (DUF3189)	Pollington J, Finn RD	anon	Pfam-B_4499 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes	20.40	20.40	25.90	22.30	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.56	0.71	-4.64	23	202	2009-01-15 18:05:59	2008-08-21 14:20:44	3	2	152	0	63	128	0	145.10	44	89.91	CHANGED	hlIYpsaGGsHSSslAAuIHLspLPhc+hPspcElhplPha-php.pp-hGplhYhGpDEhGNcVYslGhts.tphltsslcshh.plhphp...ppcllllso..hlshhh+lGGahSR+htls.hGRPllshGhppsY.plsplVcpsKpp	.......................................hhIYpsaGGoHSoslAAAhHLscLPsD.Rh.oKEEILslsaFsKLp.scDhG+llFhGhDEtGN.VYolGsts.u+lVlPAh+cLh.clLppp...pEcIlhssToPsVsl.MphGGhhSRRh+lshIGhPLllaGsphshcsl.cLVphsKc.t................................	0	37	50	58
+11218	PF11386	VERL		Vitelline envelope receptor for lysin	Pollington J, Finn RD	anon	Pfam-B_1349 (release 23.0)	Family	VERL, the egg vitelline envelope (VE) receptor for lysin, is a giant unbranched glycoprotein comprising 30% of the vitelline envelope. Lysin binds to VERL and creates a hole as VERL molecules lose cohesion and splay apart. These proteins are important in the mediation of fertilisation [1]	25.00	25.00	26.50	26.80	23.60	22.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.65	0.72	-4.01	5	193	2009-01-15 18:05:59	2008-08-21 16:03:27	3	6	11	0	0	191	0	76.70	70	39.52	CHANGED	VPITRESGINMMhIHYspNcosDSPGMCVFtGPYSVPKNDTVVLYTVTARLKWSEGPPThLSIECYMPKSPV..APEPEA	......VPITpEpGINMMLIQYoRN..ch..L.DSPGMCVFWGPYSVPKNDTVVLYTVTARLKWSEGPPT.LSIECYMPKSPs..APKPE.......	0	0	0	0
+11219	PF11387	DUF2795		Protein of unknown function (DUF2795)	Pollington J, Finn RD	anon	Pfam-B_1395 (release 23.0)	Family	This family of proteins has no known function.	21.00	21.00	21.10	21.00	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.80	0.72	-4.09	58	486	2009-01-15 18:05:59	2008-08-21 16:11:08	3	5	367	0	217	407	134	44.80	39	51.93	CHANGED	L..pshcYPusKppLlppA+cssAss.c.llcsLcplP.D+c..Ysoss-V	......LpsssaPAoK--Ll-hAt+sGAs..-.Vl-sLppl..Dcs...Y-ohp-l......	0	58	141	184
+11220	PF11388	DotA		Phagosome trafficking protein DotA	Pollington J, Finn RD	anon	Pfam-B_001493 (release 23.0)	Family	DotA is essential for intracellular growth in Legionella [1]. DotA is thought to play an important role in regulating initial phagosome trafficking decisions either upon or immediately after macrophage uptake [2].	25.00	25.00	37.20	33.00	20.20	18.20	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.32	0.72	-3.99	2	138	2009-01-15 18:05:59	2008-08-21 16:11:59	3	1	11	0	2	137	0	103.60	83	27.67	CHANGED	FDosTGLDcSsFDPsQLTKPFGKTCQssYuLLCsWFQNKSDKLlQIQSLIsGsPALuQDGVKQPDLSssPpRt.VpGPhSSTVYGFlNNSMMVQLPGQPGIKPLT	........................................FDSsTGLDsSsFDPsQLTKPFGK.TCQGTYALLCTWFQNKSDKLVQIQSLIN.GsPALSQDGVKQPDLSPsPpRthVEGPLSSTVYGFlNNSMMVQLPGQPGIKPLT.	0	1	1	2
+11221	PF11389	Porin_OmpL1		Leptospira porin protein OmpL1	Pollington J, Finn RD	anon	Pfam-B_001515 (release 23.0)	Family	OmpL1 is a member of the outer membrane (OM) proteins in the mammalian pathogen Leptospira. Specifically, it is a porin [1].	25.00	25.00	49.90	48.90	19.00	18.20	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.82	0.70	-5.34	3	83	2009-01-15 18:05:59	2008-08-21 16:12:22	3	1	36	0	4	74	1	247.50	83	87.46	CHANGED	ITKDGLDAATYYGPVRSTDTCTVGPSDPTCVQNPuKPAGEGNYlGVAPRKAIPAENRLITLDRTTGGlINARSTKGAMVGGNLMVGYESDFGKYFFWRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKLNVTEDAAVYMGAGLNYFNGGWSLNGSNNIKGGHDILAAAGAGSVANLLSDGTDPITTREHVRFRTSGIAPNFLIGTQARVTDKGHVFLELETIMSAAYAVGKTQSlGGAsTLuPFPAYPIVVGGQI	.........................ITKDGLDAATaYGPVRSTsTCT.VussDPTCVQNPuKPsGEGNYlGVuPRKAIsAENRLITLDRTTGGhINARSTKGAMVGGNLMVGYESD..FGK.YFFWRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKL.NVTEDAAlYMGAGLNYFNGGWSLNGsNNIKGGaDILAAA...Gss..oVANLLuDGTD........PlTTREHlRFRsSGIAPNFLIGTQARVTDKGH.VFlELETIMSAAYuVGKTQShGGAosLuPFPuY...........................	0	2	3	3
+11222	PF11390	FdsD		NADH-dependant formate dehydrogenase delta subunit FdsD	Pollington J, Finn RD	anon	Pfam-B_1352 (release 23.0)	Family	FdsD is the delta subunit of the enzyme formate dehydrogenase. This subunit may play a role in maintaining the quaternary structure by means of electrostatic interactions with the other subunits [1]. The delta subunit is not involved in the active centre of the enzyme [1].	20.70	20.70	21.20	44.80	20.50	19.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.05	0.72	-3.88	52	250	2009-01-15 18:05:59	2008-08-21 16:12:50	3	2	245	0	113	242	44	61.60	45	72.72	CHANGED	+LlcMANQIusFFpo..scsculsslAsHlp+FW-PRMRcpLhsh.lp......t.uuts.LsPlVhcAl	.....+LlcMANQIusFFpoh.s+c..-AlsGlAsHIp+FW-PRMR+pLhshl-......s..uut...s..LsPlVhcAl..............	0	21	62	82
+11223	PF11391	DUF2798		Protein of unknown function (DUF2798)	Pollington J, Finn RD	anon	Pfam-B_1194 (release 23.0)	Family	This family of proteins has no known function.	30.40	30.40	30.40	30.50	29.90	30.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-8.73	0.72	-4.22	84	363	2009-09-10 17:28:17	2008-08-21 16:15:59	3	2	310	0	117	347	466	59.20	27	71.18	CHANGED	llMShhMuhl..hoslhohhsh.Ghs.s..sFhtpWhpuahlAaslAhshsl.llsPhlp+lstpls	............hhhuhhMuhl...hShlhohhsh.Ghss.....talttWh.p.uahlAaslAFsssl.llhPll++lsthh.......	0	24	71	99
+11224	PF11392	DUF2877		Protein of unknown function (DUF2877)	Pollington J, Finn RD	anon	Pfam-B_002434 (release 23.0)	Family	This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.	25.00	25.00	26.70	26.50	22.60	23.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.31	0.72	-3.85	21	929	2009-01-15 18:05:59	2008-08-21 16:23:37	3	3	528	0	50	363	13	109.10	43	39.83	CHANGED	hlGhG.GLTPSuDDhLsGhh.uhhhh.t...pshpphht.htphlths..pTTtlStphLppAhpGphspsltpLhtslhpst..spstpslcplls.lGuoSGsDhLhGlhhuhph	................hlGhG.GLTPSuDDhLoGhl.sshahsu...........tsucphptp..htp..s..ph.p.sTTtlSsthLchAhQGhhspslh+F.....lHsl.ts......t...............ps......s.pAI-...plht.lGpoSGsDhLhGhhhGppL..........	0	24	36	42
+11225	PF11393	IcmL		Macrophage killing protein with similarity to conjugation protein	Pollington J, Finn RD	anon	Pfam-B_002787 (release 23.0)	Family	IcmL contains two amphipathic beta-sheet regions, required for the pore-forming ability which may be related to the transfer of this protein into a host cell membrane [1]. The icmL gene shows significant similarity to plasmid genes involved in conjugation however IcmL is thought to be required for macrophage killing. It is unknown whether conjugation plays a role in macrophage killing [2].	21.00	21.00	21.10	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.11	0.72	-4.11	23	289	2009-01-15 18:05:59	2008-08-21 16:26:36	3	3	199	0	37	173	10	101.70	27	48.53	CHANGED	su+Ih.l.Ph-pPthspstlhsaupcslhpuashDassYcsplsphtsp.FTppGats.ahsuLppSshLcsl+sp+hslsusss..usspllppshh..tshhtWplphPlpl	...................................shppshhspsthhpauspslspuFshDa..spacppl.ssltst.aos.cGatt.ahs.AL.p.s.SsllcslKcc+h.sls.sss..Gsullsppsph....tshhhWphphPlhh...........	0	19	23	32
+11226	PF11394	DUF2875		Protein of unknown function (DUF2875)	Pollington J, Finn RD	anon	Pfam-B_002814 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	20.70	20.70	21.70	22.10	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	451	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.49	0.70	-5.92	8	205	2009-01-15 18:05:59	2008-08-21 16:27:43	3	2	67	0	20	260	0	232.10	34	83.25	CHANGED	AppuppYsLElRGlGlslsp.pQpcIW+cIccKssNauSlhSQcPcDYssS.soRps-hclsspsAFKauApcuV-YWPlPVhllGPP+shccua..RAAusIsusRppAoLGVTLFLWQ-DtNTscupuMlE+LFsFFDsHPDVPpALlhSpDGslsRshhRsPG...oss..psuphVPshPDSMsAlLVoRSDRVDRhIRPYAV-psEtlspssTpaDlsKLWNFaW-psc.....uFssaYE..AspKptGscsP.ususMSosaWQupLPsLWKTIuNKGPGpFcPSPalPVRWspWQVKpFDsAPlLGYLHRPI+VpLsD-HGKPLKsAtQAcAL+AGWtQAlsTLP-GpK.PsRVFYDTTsspthtIsLsQALHsls..upul-LuDV+EGYDIGRRl.GNTGVSSsLVQIuLAlIASYcDGGsSAsVptpssGoATIhMVSPPDtApKAttsQsp.GscPF	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	4	8	11
+11227	PF11395	DUF2873		Protein of unknown function (DUF2873)	Pollington J, Finn RD	anon	Pfam-B_002845 (release 23.0)	Family	This viral family of proteins has no known function.	25.00	25.00	57.00	57.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.32	0.72	-4.39	2	75	2009-01-15 18:05:59	2008-08-21 16:30:08	3	1	73	0	0	10	0	43.00	96	97.46	CHANGED	MsELTLIDFYLCFLAFLLFLVLIMLIIFWFSLElQDlEEPCsK	MNELTL..IDFYLCFLAFLLFLVLIMLIIFWFSLEIQDLEEPCTK.	0	0	0	0
+11228	PF11396	DUF2874		Protein of unknown function (DUF2874)	Pollington J, Finn RD	anon	Pfam-B_002962 (release 23.0)	Domain	This bacterial family of proteins is probably periplasmic and of unknown function.\	    There may be between one and six copies of this domain per sequence.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.79	0.72	-4.00	181	1589	2012-10-01 23:09:26	2008-08-21 16:38:52	3	9	279	21	355	1152	36	57.30	21	63.99	CHANGED	psl.shsplPss....lpstlppp..asstp.lpc....hphpp........phYclclp.......tpphclhasppGphl	.................h..hstLPps.......lpshlppp...asssp.ltc.....lcpcp........stYclcls.........sphclhFstpGphh.....	0	136	252	283
+11229	PF11397	GlcNAc		Glycosyltransferase (GlcNAc)	Pollington J, Finn RD	anon	Pfam-B_002901 (release 23.0)	Family	GlcNAc is an enzyme that carries out the first glycosylation step of hydroxylated Skp1, a ubiquitous eukaryotic protein, in the cytoplasm [1].	20.40	20.40	20.40	20.60	20.30	20.00	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-12.12	0.70	-5.33	25	216	2012-10-03 05:28:31	2008-08-21 16:46:00	3	11	113	0	109	246	398	269.10	25	60.42	CHANGED	oIFVslASYRDsEhhsTLcsLhspAspPcRLalGVs.Qpts..s-ss...........................................................................................................ssFhsc...........................tht.........h.tsplphhslssspu+GssaARahspthYpsEcYhLplDSHpRFl.sWDppllshlppLp.........ssKsVLSsYPsGYps...tsppphpcpsssththspF.sspGhlplp..........................uphhss.pp.ttP.....l.ssalAuGFlFucGp.Fs+-VPaDPal..hFpGEElhhosRhaT+GaDlYsPs+sl..laHhYsR.....sspsKhWs-pp....................tpWhtppppScpRsphLL..................................shtsspss........hhthshYGlGspRolspa.pauGlshtp	......................................................................................................................lFlsluuaRD...p.hh.Tl.shhppAttP.ppl.hulh.Q.....t.s.........................................................................................................................................................................................................................t..h.tsplphhphph.pupGsshARahsp....t....ha.....ts...EpahhplD.SHhpFh.tWDp.hlt.hptht.................................s.pslLotYP..s...hp...............ttt....t.p.p.h...h.hhhht.h....ttp..Gh.hphh..........................................u.t.ht..............P...........h.t..ahu.uG.a..Fupup.hhpcV.P.hDPph...hF.GEE.hhh.......usRhaTpGaDh.YsPpp..s..l..haH..Ypp.........tptsphaps.........................th....t..pphu.hpRhhhhl..................................................................................h..ht.ashGp.Rohtpa..h.sls...t..................................................................................	1	60	86	105
+11230	PF11398	DUF2813		Protein of unknown function (DUF2813)	Pollington J, Finn RD	anon	Pfam-B_002207 (release 23.0)	Family	This entry contains YjbD from Escherichia coli (Swiss:P75828), which is annotated as a nucleotide triphosphate hydrolase.	20.40	20.40	20.40	20.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.24	0.70	-5.38	21	824	2012-10-05 12:31:09	2008-08-21 16:54:35	3	5	785	0	109	1485	191	326.10	57	61.92	CHANGED	MaLERIEIsGFRGIpRLSLslcp.sVLIGENuWGKSSLLDALSLlLss-scLYpFshpDFHhs.u.ppsps+cLpllhTFpEpc.s.-ppstRY+pl..pslWs.scs.GhcRIYYRlpuphs.sssVpTphuFLDtpGps..lslcch-pLsppLlplHPVlRlRDA...RRhtptph.tt.t.p........Rlp+clcphhRcLhspPtplsc..sEl+puLpAhppLl-HYFu.pstppsp.+ph+cp.ppsppsaph..hpslsphlcpsss..+phRllLlGllsshLpA+Gshp..Lc+tARPILLlEDPEsRLHPhMLulAWpLLshLPhQ+IsTTNSuELLS.VPLcpIpRLVRpoc+stuapLs.psLop-DhRRIuFHIRaNRstA	...............................................................................................................................................................................................................MhLERV.EIVGFR....G.I.....N.R.......L..S...L.h.L...-...........p.......N...s.....V...L..I...GENAWGKS...S...LL.D...A...L.......T.L.....L......L.......S.......P..........E.......s.....c....L.....Y......H......F...p..c...c......D.....F..a...a....Ps.....G....D......h.........p......u....+.E..+...H......L.p....I...I....L.........T..Fc......E.o...sG.....+.....a........+.s.....p..R.Y..R.sL...........css...W...........s.s.s.p.D.....G...hH...R..IaYRl..E....GE.....pu...t....D....G.......o....V....h....Th..R..o...F...L....D...p...-.....GpP.......lsl...-..c.....I.....s......c...s......+.cL....l..RL.h.....PVL....R....L...RDAR............FhRRlRs.us...s.s.N.sss.s-.........................sss+QLD...L...s......REL.ss.p..P.Q..p..L.oc.........GpI..R..Q..G.L.S...A.M.sQ.L.LEHYF......................SE....Quu.....u.....p......s..c.h.R...hh...Rc..+..s....p.s...c...pcu.W+h.............LD.I..N.RMI....c....cP.s..u..........RS.h..RlIL.....L.GLF..uTL......L.Q.AK...G..o.lc......L.c+...c..A...R.P....LL.L.lEDPETRLHP...I.M.......L.S..V....A.W....p....L.L......s........L....L........P......L....Q....R....I.....sTTNSGEL..L..S..L.s..PlE.pls..RLVRESu.R.V..AAaRL..GPsG..............LS.sEDuRRIu..FHIRFNRsSu.............................................................................................................................................................................................................................	0	15	46	81
+11231	PF11399	DUF3192		Protein of unknown function (DUF3192)	Pollington J, Finn RD	anon	Pfam-B_002991 (release 23.0)	Family	Some members in this family of proteins are annotated as lipoproteins however this cannot be confirmed.	21.80	21.80	21.80	22.40	20.20	21.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.21	0.72	-4.09	32	113	2012-10-01 23:09:26	2008-08-21 16:59:05	3	1	64	0	48	96	32	102.80	40	79.35	CHANGED	susVlhlh-ssssphs.......W-c.........+pthN+pplucLpLGt..ohspVhslhGsuDFoEAhpps.......cpplpVLFYRTp+h+uDGhTTKDECTPLlFcNspL..luWGpsu.Ypph	.........................................susVl.lh-spspths.......Wcc..ppthN+pplscLsLG...ohspVhshhGssDFoEAhtpp.......cpplpVLFYRTp+....p+SDGhTT.KDECTPLlFcNspL..luWGpsAYpph...............	0	8	20	34
+11233	PF11401	Tetrabrachion		Tetrabrachion	Pollington J, Finn RD	anon	pdb_1fe6	Family	Tetrabrachion forms a parallel right-handed coiled coil structure with hydrophobic interactions and salt bridges forming a thermostable tetrameric structure. It contains large hydrophobic cavities. No function is known for this family of proteins [1].	20.50	20.50	21.60	114.20	18.10	17.00	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.60	0.72	-4.17	2	2	2009-01-15 18:05:59	2008-08-22 10:30:29	3	1	2	8	1	5	0	49.00	100	3.22	CHANGED	IINETADDIVYRLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILAS	IINETADDIVYRLTVIIDDRYESLKNLITLRADRLEMIINDNVSTILAS	0	1	1	1
+11234	PF11402	Antifungal_prot		Antifungal protein	Pollington J, Finn RD	anon	pdb_1afp	Family	Antifungal protein consists of five antiparallel beta strands which are highly twisted creating a beta barrel stabilised by four internal disulphide bridges [1]. A cationic site adjacent to a hydrophobic stretch on the protein surface may constitute a phospholipid binding site [1].	25.00	25.00	41.10	40.80	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.05	0.72	-3.77	6	27	2009-01-15 18:05:59	2008-08-22 10:34:21	3	1	23	2	9	23	0	52.00	53	56.43	CHANGED	ApYsGKCaKKDNhCKYKspuGKTsIsKC.s...K+Cs+DGsKCEaDSY+sKsh	l.cYhGKCTKu-NpCKYKsDpGKsslppCPphs..NKKCsKDGNpCcaDShs+......	0	0	2	6
+11235	PF11403	Yeast_MT		Yeast metallothionein	Pollington J, Finn RD	anon	pdb_1aoo	Family	Metallothioneins are characterised by an abundance of cysteine residues and a lack of generic secondary structure motifs. This protein functions in primary metal storage, transport and detoxification [1]. For the first 40 residues in the protein the polypeptide wraps around the metal by forming two large parallel loops separated by a deep cleft containing the metal cluster [1].	25.00	25.00	93.70	93.70	21.20	19.80	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.76	0.72	-3.81	2	7	2009-01-15 18:05:59	2008-08-22 10:37:10	3	1	6	6	2	4	0	40.00	100	65.57	CHANGED	QNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGN	QNEGHECQCQCGSCKNNEQCQKSCSCPTGCNSDDKCPCGN	0	2	2	2
+11236	PF11404	Potassium_chann		Potassium voltage-gated channel	Pollington J, Finn RD	anon	pdb_1b4g	Family	Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons [1]. Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation [1].	20.00	20.00	20.20	23.80	17.90	19.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.18	0.72	-4.16	2	56	2009-01-15 18:05:59	2008-08-22 11:11:04	3	3	29	3	24	54	0	28.50	76	4.63	CHANGED	MlSSVCVSSh.+GRKuGNKsssKsChpt-Ms	..MISSVCVSSY.RGRKSGNKPPSKoCLKEEMA...	0	2	7	13
+11237	PF11405	Inhibitor_I67	Bromelain_inhib;	Bromelain inhibitor VI	Pollington J	anon	pdb_1bi6	Family	Bromelain inhibitor VI is a double-chain inhibitor consisting of a 11-residue and a 41-residue chain. This protein is the 41-residue heavy chain which is joined to the 11-residue chain by disulphide bonds. The inhibitor acts to inhibit the cysteine proteinase bromelain [1].	25.00	25.00	298.50	103.10	18.80	17.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.45	0.72	-3.91	2	3	2009-09-25 10:05:36	2008-08-22 11:27:54	3	1	1	2	0	4	0	41.00	95	50.00	CHANGED	-EYKCYCsDTYSDCPGFCKpCKAEFGKYICLDLISPNDCVK	EEYKCYCTDTYSDCPGFCKKCKAEFGKYICLDLISPNDCVK	0	0	0	0
+11238	PF11406	Tachystatin_A		Antimicrobial peptide tachystatin A	Pollington J	anon	pdb_1cix	Family	Tachystatin A contains a cysteine-stabilised triple-stranded beta-sheet and shows features common to membrane-interactive peptides. Tachystatin A is thought to have an antimicrobial activity similar to defensins.Tachystatin A is also a chitin-binding peptide [1].	25.00	25.00	39.90	39.90	22.80	18.70	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.57	0.72	-4.10	2	3	2009-01-15 18:05:59	2008-08-22 11:36:20	3	1	1	1	0	4	0	36.30	96	82.58	CHANGED	YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQRa	YSRCQLQGFNCVVRSYGLPTIPCCRGLTCRSYFPGSTYGRCQRa	0	0	0	0
+11239	PF11407	RestrictionMunI		Type II restriction enzyme MunI	Pollington J	anon	pdb_1d02	Family	Type II restriction enzyme MunI recognises the palindromic sequence C/AATTG. It makes contact with the DNA via the major groove [1].	25.00	25.00	85.10	84.90	18.90	17.30	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.61	0.71	-4.70	2	9	2012-10-11 20:44:46	2008-08-22 12:45:49	3	1	8	2	3	11	4	168.90	46	99.93	CHANGED	MGKpELpsR.sWQthuGLhuptAEpph.sVF.A.FpGTcYVlhccPKcLKslYup............NP.......paGVS.DaAIpNpcT+KhLasEIKpQ-GaV.Gcs.PpsGRGNAHERSCKhFTPGLLKshpplusl.s.thLPFWlVapGcITRDsKRsREITaWaDcYtspaFhW+ss.Sup.LlpHFpcpL++hLD	....Mupp-LptRtsWQs.SG..h..tAtsAEpshhssFptsFc...sTcYhlpp+Pp-hKslYspV.Lstp.httIasP......p........hhp......aGlS.DaAIpNpcTtKhlasElKRQDGWVEGtp..SsGRGNAHER.CKhFTPGLhcshRphutl.s.thLPFWlVh.GDITRDPpRsREIsaWappYptpaFhWRss.stpsLlpHFpp.Lh.hL......	0	3	3	3
+11240	PF11408	Helicase_Sgs1		Sgs1 RecQ helicase	Pollington J, Finn RD	anon	pdb_1d8b	Family	RecQ helicases unwind DNA in an ATP-dependent manner. Sgs1 has a HRDC (helicase and RNaseD C-terminal) domain which modulates the helicase function via auxiliary contacts to DNA [1]. 	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.46	0.72	-4.15	5	29	2012-10-03 03:05:55	2008-08-22 12:54:14	3	2	28	1	20	63	15	77.40	40	5.87	CHANGED	ElscLshuYERLRslulslGNRMNPPlssaM.PDslLKKlAshLPATE-EFlsLlGsN-ss.sRKYKYFKcTltcLRK+Rpc	.......EhsslphsYc+LRElSlslGsRMsP.P.l.ss.Fh.sDslLKKhAshLPhs-ppFspLsslpcp..pc+F.KY..FKsTlhcLp+cRp.p..............	0	1	10	18
+11241	PF11409	SARA		Smad anchor for receptor activation (SARA)	Pollington J	anon	pdb_1dev	Family	Smad proteins mediate transforming growth factor-beta (TGF-beta) signaling from the transmembrane serine-threonine receptor kinases to the nucleus [1]. SARA recruits Smad2 to the TGF-beta receptors for phosphorylation [1].	25.00	25.00	27.00	27.00	20.50	18.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.10	0.72	-4.04	3	74	2009-01-15 18:05:59	2008-08-22 13:01:21	3	6	56	3	44	72	0	40.10	79	3.24	CHANGED	uRSPNPNNPMEYCSTIPPaQQAssSP..uSPPPSVMVPVGV	...pSPNPNNPAEYCSTIPPLQQAQ.A..SGsLuSPPPTVMVPVGV.	0	8	15	28
+11242	PF11410	Antifungal_pept		Antifungal peptide	Pollington J	anon	pdb_1dkc	Family	This peptide has six cysteines involved in three disulphide bonds. It contains a global fold which involves a cysteine-knotted three-stranded antiparallel beta-sheet along with a flexible loop and four beta-reverse turns. It also has an amphiphilic character which is the main structural basis of its biological function [1].	21.00	21.00	21.60	21.30	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.43	0.72	-3.86	8	33	2009-09-11 11:38:32	2008-08-22 13:09:29	3	2	21	2	11	33	0	33.30	43	33.95	CHANGED	CIsNGutCpsDuu.ssCCSGFCap.p.PG..hshGhC+sR	.......IssGtsCptDGShG.CsSGaChp.t..s...s.GhC+........	0	1	4	9
+11243	PF11411	DNA_ligase_IV		DNA ligase IV	Pollington J	anon	pdb_1ik9	Family	DNA ligase IV along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface [1].	21.20	21.20	21.20	21.90	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.59	0.72	-4.21	7	68	2009-01-15 18:05:59	2008-08-22 13:42:40	3	9	55	4	47	66	1	35.80	55	4.08	CHANGED	ST+cHFAcEYDpYGDSYhsDTsttpL+-VFpplpss	.....ST+cHFA+EY.DsYGDSYasDTDh.sQLKEVFstI+s......	0	14	18	30
+11244	PF11412	DsbC		Disulphide bond corrector protein DsbC	Pollington J	anon	pdb_1jpe	Family	DsbC rearranges incorrect disulphide bonds during oxidative protein folding. It is activated by the N-terminal domain of DsbD, a transmembrane electron transporter. DsbD binds to a DsbC dimer and selectively activates it using electrons from the cytoplasm [1].	21.60	21.60	21.70	21.60	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.96	0.71	-4.27	187	2597	2009-01-15 18:05:59	2008-08-22 13:54:41	3	21	2012	10	617	2080	1106	118.10	24	21.34	CHANGED	pschLssppA.h..........tsssp...pltlphp.lssGaalYhcph..th.....ph.....pssssh....hsphpaPss.p...hhpD.th...ps.sYc.spltlsls..lssss............tth...plplsaQuCs-..slChPspsphhhhhs	....................................t...hl..ppA.F.hph.........ppspp....plslphp..lp.s.Gaa.lYp.cph.........h.......................ph.ssspsh.....hup.h.p.h.P.tu..p.....hh..p...D.....pha.u...p...s...phYc.sp...l.slsls....lptss......................ssh...plplsa..QGCu-...u..hCYPPpsphh....s............	0	170	352	492
+11245	PF11413	HIF-1		Hypoxia-inducible factor-1	Pollington J	anon	pdb_1lqb	Family	HIF-1 is a transcriptional complex and controls cellular systemic homeostatic responses to oxygen availability [1]. In the presence of oxygen HIF-1 alpha is targeted for proteasomal degradation by pHVL, a ubiquitination complex [1].	17.80	17.80	17.80	18.10	16.40	17.70	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-7.85	0.72	-4.77	17	330	2009-01-15 18:05:59	2008-08-22 14:00:38	3	13	102	4	83	283	0	34.00	61	4.79	CHANGED	.sspshsDLDLEMLAPYIPMD.DDFQLsslst.s.	.......s.hspshs-LDLEMLAPYIPMD..DDFQLpshs..p.........	0	4	15	35
+11246	PF11414	Suppressor_APC		Adenomatous polyposis coli tumour suppressor protein	Pollington J, Finn RD	anon	pdb_1m5i	Family	The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils [1].	22.70	22.70	23.30	23.50	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.58	0.72	-4.20	13	215	2009-01-15 18:05:59	2008-08-22 14:08:54	3	43	72	1	114	197	0	80.70	35	6.60	CHANGED	ssashL+phcpLEcE+-hLLtGL-tlE+u+-WYhsQLpslQcp.cplGphusth-hho-hppcpLshphs+lpclNcsLttLhp	...................ht.hphhcELEpE+....slLLtsL-t.E+t+-WYhs.QLpslpcRhc......pLstscs.......h...........shtoDhppcp.Lphpttplpps.cphhshh...................	0	20	29	61
+11247	PF11415	Toxin_37	Termicin;	Antifungal peptide termicin	Pollington J	anon	pdb_1mm0	Family	Termicin is a cysteine-rich antifungal peptide which exhibits antibacterial activity. A cysteine stabilised alpha beta motif is formed due to an alpha-helical segment and a two-stranded antiparallel beta-sheet [1].	25.00	25.00	41.00	41.00	19.80	16.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.18	0.72	-4.33	8	150	2012-10-01 23:31:40	2008-08-22 14:24:34	3	1	18	1	0	139	0	34.90	64	56.29	CHANGED	CsFpSCWAoCQtQHGIYFRRAaCDGSpCpCValNG	..CshppCWAsCQApHGRYFRRAYC-GShC+CVFNNG....	0	0	0	0
+11248	PF11416	Sed5p		Integral membrane protein Sed5p	Pollington J, Finn RD	anon	pdb_1mqs	Family	Sed5p interacts with Sly1p , a positive regulator of intracellular membrane fusion, allowing SM proteins to stay associated with the assembling fusion machinery. This allows for participation in late fusion steps [1].	21.30	21.30	22.70	21.40	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.64	0.72	-7.24	0.72	-4.51	11	45	2009-01-15 18:05:59	2008-08-22 14:31:23	3	1	44	1	30	42	0	28.10	50	8.41	CHANGED	h.sIpNRThEFQQsVsoYcKhN+Kpsspt	.M.sIpsRThEFQQsVhoYcKpNKp.ppp.......	0	5	17	29
+11249	PF11417	Inhibitor_G39P		Loader and inhibitor of phage G40P	Pollington J	anon	pdb_1no1	Family	G39P inhibits the initiation of DNA replication by blocking G40P replicative helicase. G39P has a bipartite stricture consisting of a folded N-terminal domain and an unfolded C-terminal domain. The C terminal is essential for helicase interaction [1].	20.40	20.40	20.80	20.70	20.10	20.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.42	0.72	-3.99	2	43	2009-01-15 18:05:59	2008-08-22 14:38:22	3	1	41	3	6	44	42	67.20	27	43.94	CHANGED	MI.c-slpILphlpthYP...tchpPsDhKshVphWpphLt-Y.hp.l..slpchhtsNKFPPoVu-llcA	.........................Mhcp-shcllthlpssYP....php...p...s........c..t....hlslWhphL.cDhsaphlttslcpal..t..ss.p..aPPolA-lh..p............	1	4	5	5
+11250	PF11418	Scaffolding_pro		Phi29 scaffolding protein	Pollington J	anon	pdb_1no4	Family	This protein is also referred to as gp7. The protein contains a DNA-binding function and may halve a role in mediating the structural transition from prohead to mature virus and also scaffold release [1].Gp7 is arranged within the capsid as a series of concentric shells [1].	25.00	25.00	28.00	80.70	22.70	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.27	0.72	-3.67	3	7	2009-01-15 18:05:59	2008-08-22 14:45:34	3	1	5	11	0	9	0	91.00	65	97.55	CHANGED	PLchEEHE-ILNKLsDPELscSERTEALQQLRssYGSFlSEYsELTcApEKLsAEK-DLIVSNSKLF...RQlGLTcKKEE..EcKQc-lSETITIEDLEup	.Phc.-pHE-ILNpL.DPELspSERTEALQQLRssYGSFlSEYsDLTcopEKLsAEK-DLIVSNSKLF...RQlGlTccpEE..-hKpt-lSETITIEDLEtp	0	0	0	0
+11251	PF11419	DUF3194		Protein of unknown function (DUF3194)	Pollington J	anon	pdb_1pu1	Family	This family of proteins has no known function however the structure has been determined. The protein consists of two alpha-helices packed on the same side of a central beta-hairpin [1].	21.50	21.50	21.90	22.00	20.40	21.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.77	0.72	-3.78	4	34	2009-01-15 18:05:59	2008-08-22 17:01:13	3	1	34	1	25	37	2	83.60	34	86.78	CHANGED	IGLPcLoEE-LIElG-luQ+lIIcaIF-+Lu+SEV+DlEVTsRINpGETLDLELEVYlEVPlFV+VDVEuLIDEAlDKAYculEcaL	..................h.cLsptpl.clu-hAtcsh.thlFs+l.spS-VcDl-VTlplpc...s.psLsLEl-VYlpsP.hsc.sDs-pllD-AlcpAhpsV-ch....	0	4	11	19
+11252	PF11420	Subtilosin_A		Bacteriocin subtilosin A	Pollington J	anon	pdb_1pxq	Family	Subtilosin A is a bacteriocin from Bacillus subtilis.The protein has a cyclized peptide backbone and forms three cross-liks between the sulphurs of Cys13, Cys7 and Cys4 and the alpha-positions of Phe22,Thr28 and Phe31 [1].	25.00	25.00	33.90	33.80	18.10	16.60	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-7.79	0.72	-3.92	2	17	2009-01-15 18:05:59	2008-08-26 12:13:47	3	1	16	1	2	6	0	33.70	94	77.33	CHANGED	NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG	NKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG.	0	1	1	1
+11253	PF11421	Synthase_beta		ATP synthase F1 beta subunit	Pollington J	anon	pdb_1pyv	Family	The NMR solution structure of the protein in SDS micelles was found to contain two helices, an N-terminal amphipathic alpha-helix and a C-terminal alpha-helix separated by a large unstructured internal domain. The N-terminal alpha-helix is the Tom20 receptor binding site whereas the C-terminal alpha-helix is located upstream of the mitochondrial processing peptidase cleavage site [1].	20.90	20.90	22.10	39.10	20.20	20.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.61	0.72	-3.30	12	41	2009-01-15 18:05:59	2008-08-26 12:47:47	3	3	21	1	19	40	0	45.40	55	8.25	CHANGED	MASRRlLSSLLRSouR+p...uu+.......sPthssst.u......RsSPsGaLLNR	MASRRlLSSLLRSuSRtp...uu........sPthssPp..hp.....RsSPsGaLLNR	0	3	10	14
+11254	PF11422	IBP39		Initiator binding protein 39 kDa	Pollington J	anon	pdb_1q87	Family	IBP39 recognises the initiator which is solely responsible for transcription start site selection. IBP39 contains an N-terminal Inr binding domain connected to a C-terminal domain. The C domain structure indicates that it interacts with the T. vaginalis RNAP II large subunit C-terminal domain. Binding of IBP39 to Inr recruits RNAP II and initiates transcription [1].	25.00	25.00	184.80	184.10	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.34	0.71	-4.77	7	7	2009-01-15 18:05:59	2008-08-26 13:06:39	3	1	1	5	7	8	0	181.70	26	53.63	CHANGED	hcslpIhths.pppppF+ppslphWpcllp.stth.shshp.FIcthsppF...................ptspQshcN........uhpsIp.lLsspssshlThsDFhpFhAtFGP.-olhhKItphL..s.t.tpWL.h..pPph.pphs....slsuaFsps..NChlhph.sGhpa+saNhPhl.sususYLhDEssppapSWcphhp.h	..cslpIhths.pppppF+ppslphWpcllp.stth.shshp.FIcthsppF...................ptspQshcN........uhpsIp.lLsspssshlThsDFhpFhAtFGP.-olhhKItphL..s.t.tpWL.h..pPph.pphs....slsuaFsps..NChlhph.sGhpa+saNhPhl.sususYLhDEssppapSWcphhp...	0	7	7	7
+11255	PF11423	Repressor_Mnt		Regulatory protein Mnt	Pollington J	anon	pdb_1qey	Family	Mnt is a repressor which is involved in the genetic switch between lysogenic and lytic growth in bacteriophage P22. The C-terminal domain of the protein consists of a dimer of two antiparallel coiled coils with a right handed twist, which is both stronger and has closer inter-helical separation compared with those found in left-handed coiled coils [1].	20.90	20.90	25.70	34.00	19.30	17.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.69	0.72	-7.10	0.72	-4.63	3	59	2009-01-15 18:05:59	2008-08-26 13:11:58	3	2	55	6	1	38	0	29.60	66	36.09	CHANGED	RDDAERhADpQSElVKKMVFETLKDhY+K+	.DDAERhA-pQS-hVKKhVFDTLKclY+K.s.	0	0	0	0
+11256	PF11424	DUF3195		Protein of unknown function (DUF3195)	Pollington J	anon	pdb_1rki	Family	This archaeal family of proteins has no known function.	25.00	25.00	64.20	64.00	19.80	18.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.18	0.72	-3.80	4	9	2009-01-15 18:05:59	2008-08-26 13:26:27	3	1	9	2	6	10	0	82.00	44	90.33	CHANGED	alIl+TlPKKEtIVARDLCDClYYYDppVhC+slusuRVYlhTpl-hLcpCLph+YF+KLlKslElaD.Vpp.cPs.CscChllpIG-VY	...lllpTls+KEthVARDLCDCLYaa.DptVhCcsluPG+VYVpT.p.hphLcpCLsM+YFKpLlKtlElaDcVSp.pPs.ps.shh.................	0	1	2	3
+11258	PF11426	Tn7_TnsC_Int	Tn7_TnsC;	Tn7 transposition regulator TnsC	Pollington J	anon	pdb_1t0f	Family	TnsC is a molecular switch that regulates transposition and interacts with TnsA which is a component of the transposase. The two proteins interact via the residues 504-555 on TnsC. The TnsA/TnsC interaction is very important in Tn7 transposition [1].	20.30	20.30	20.70	23.30	19.30	18.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.19	0.72	-4.25	10	45	2009-01-15 18:05:59	2008-08-26 14:47:22	3	2	43	2	12	38	1	46.90	38	8.70	CHANGED	IKps-WcTLcS-DLRFlaSQssssp.shYptLcssGLlFDlpuhh+csG	....lK.s-WcoLsssDLRalYSQppspp.sha-pLKpp.Gl.IlDhpslhpt.....	1	3	6	7
+11259	PF11427	HTH_Tnp_Tc3_1	Tc3_transposase;	Tc3 transposase	Pollington J	anon	pdb_1tc3	Family	Tc3 is transposase with a specific DNA-binding domain which contains three alpha-helices, two of which form a helix-turn-helix motif which makes four base-specific contacts with the major groove. The N-terminus makes contacts with the minor groove. There is a base specific recognition between Tc3 and the transposon DNA. The DNA binding domain forms a dimer in which each monomer binds a separate transposon end. This implicates that the dimer has a role in synapsis and is necessary for the simultaneous cleavage of both transposon termini [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.24	0.72	-4.33	2	160	2012-10-04 14:01:12	2008-08-26 14:57:22	3	12	12	2	152	76	7	47.00	39	24.22	CHANGED	RGouLSDhEpu.l.sM+..ssplpEhup+lsRpRpCIpcaLKsPspYGso	...............lo..EpAplDlM.hQLG.hSlptMS+plsRSRsslcpY..lsDPlsYG..t.......	0	8	136	152
+11260	PF11428	DUF3196		Protein of unknown function (DUF3196)	Pollington J	anon	pdb_1td6	Family	This proteins is the product of the gene MPN330 and is thought to involved in a cellular function that has yet to be characterised. The proteins has 11 helices and a novel fold [1]. No function is currently known for this protein.	26.70	26.70	26.80	26.80	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.81	0.70	-5.11	5	47	2009-01-15 18:05:59	2008-08-26 15:32:04	3	3	47	1	11	28	1	224.10	27	86.95	CHANGED	Ml....KK.sshlKphsshKppFtshppl.pshpp...tN.DpLTpFFhslLpKlcsLVKcKDFKpAh-plpEELsoPYlPhsLluaFcuhhhlIs+sL.....aEsENstLAsLs+c-llsplLssaPs..sLshlcYLLsKpcsFlcss-LphhsalLTsKclh-lcKhshhpALspIssFlsppF-YYNSKLKQpFslTLscFslhtp.sopsYFsQLlcplpphFhKEPSppEFAsEIIssllVsYFPhHPsa.slscLApsIaQYVpNslpNclsshKs.ElpKlIVcslhcpLDc	.............................................h........................................ppYa--ILcplcpllcc+castAhslIspELshPYIPh.....hhppFcphhhclK+ph............h.pp.t.....sp.Lsppphhphltpshsp..plshhph.hh.+.ht.hp.....l..t..hpphL.spphtt.sKh.ll.hLt..p..IsppFphhpphhcpoh.ls.hp.s.....pt...h.pl.s.lpp..h...K.s.Pshhphsppll..hhh.haPhh..h.p.p.lAhsIhtYhppthts..hphp......p.l..........................................................................................................................	0	6	9	10
+11261	PF11429	Colicin_D		Colicin D	Pollington J	anon	pdb_1tfk	Family	Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA cleavage. It targets the four isoaccepting tRNAs for Arg and cleaves the phosphodiester bond between positions 38 and 39 at the 3' junction of the anticodon stem and the loop [1].	21.70	21.70	22.90	23.70	21.50	19.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.24	0.72	-3.83	8	39	2009-01-15 18:05:59	2008-08-26 15:48:53	3	10	37	3	7	52	0	87.90	39	12.70	CHANGED	QLpKKFK.HAsDFGlsspstNppTLscFcDsIpcHlusssTVpKGTYRptpsSKVYaNssTthsVIlcpsGsFl..SGW+lsPto-phphYlcss	.....QLpKKaK.HAsD.FGlsspptNppTL.spFccuIppHlsst..sT.lp.cGTYRt...tpsSKVaaNss.TspsVllcpsGpFl..SGWKlsPtspphp.ahps.h..........	0	3	5	6
+11262	PF11430	EGL-1		Programmed cell death activator EGL-1	Pollington J	anon	pdb_1ty4	Family	Initiation of programmed cell death in C.elegans occurs by the binding of EGL-1 to CED-9 which disrupts a complex involving CED-4/CED-9 and allows CED-4 to activate CED-3, a caspase. It is the C terminal domain of EGL-1 which is involved in the formation of the complex with CED-9. The formation of the complex induces structural rearrangements in CED-9 and EGL-1 adopts an extended alpha-helical conformation [1].	20.50	20.50	23.50	22.70	19.90	15.70	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.40	0.72	-6.46	0.72	-4.32	3	13	2009-09-11 00:00:58	2008-08-26 16:23:42	3	2	5	2	13	13	0	20.90	62	19.47	CHANGED	Y-IGoKLAAMCD-FDAEMMSY	.a-IGoKLAsMCDDFDAcMMSY..	0	2	3	13
+11263	PF11431	Transport_MerF		Membrane transport protein MerF	Pollington J	anon	pdb_1waz	Family	The mercury transport membrane protein, MerF has a core helix-loop-helix domain. It has two vicinal pairs of cysteine residues which are involved in the transport of Hg(II) across the membrane and are exposed to the cytoplasm [1].	21.20	21.20	21.50	22.00	19.40	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.13	0.72	-4.31	13	68	2009-01-15 18:05:59	2008-08-26 16:37:18	3	2	60	3	14	54	6	45.20	58	57.94	CHANGED	TPlLVILLGsVGLSAlsGaLDaVLLPALAlFIuLTlYALW++pppp	....TPlLVILLGsVGLuALsG..YLDYVLLPALAlFIGLTlYAlhR+cpt.s......	0	6	10	13
+11264	PF11432	DUF3197		Protein of unknown function (DUF3197)	Pollington J	anon	pdb_1wn9	Family	This bacterial family of proteins has no known function.	20.60	20.60	21.00	106.70	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.41	0.71	-4.07	3	15	2009-01-15 18:05:59	2008-08-26 16:40:03	3	1	15	2	9	15	0	113.80	55	85.09	CHANGED	hQAlpA+Lscl-LoEARLlLITDRQDERsQARYAALLThG+....EALLoAPAFGPAYGPuGAcALAELVRWApupGh.RspETVLSuGDFsRVLAEPDA-EV+RLlAAoNPoDPAIY	..LcALKsAL...cGl+hsEAKVhLITDWQD+R-pARYAL.LL+sGK....+cLLssDAFGPAF.PuGEcALuELVuhLlppGAR+FYEAVVSPGEhsuLL-LPPEEll+RlhAhANPTDPuIY	0	2	5	9
+11265	PF11433	DUF3198		Protein of unknown function (DUF3198)	Pollington J	anon	pdb_1x9b	Family	Some members in this family of proteins are annotated as membrane proteins however this cannot be confirmed. Currently, this archaeal family has no known function.	25.00	25.00	58.40	58.00	21.40	18.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.44	0.72	-4.09	3	4	2009-01-15 18:05:59	2008-08-26 16:42:54	3	1	4	1	4	6	4	51.00	50	41.21	CHANGED	L+DTu+FEShINSsSKSVFVRNLsELERLAKRLGKSYcIQLEpAKEKWKVK	L+Dph+FEphINSpSKphFVcNLsELEcluh+LGcuYp.pLEpAKcKWKVK	0	2	3	3
+11266	PF11434	CHIPS		Chemotaxis-inhibiting protein CHIPS	Pollington J	anon	pdb_1xee	Family	The chemotaxis inhibitory protein, CHIPS, is an excreted virulence factor which acts by binding to C5a and formylated peptide receptor (FPR), blocking phagocyte responses. A fragment of CHIPS, which contains residues 31-121 comprises of an alpha helix packed onto a four stranded anti-parallel beta-sheet. Most of the conserved residues of CHIPS are present in the alpha-helix [1].	25.00	25.00	43.10	42.30	20.00	18.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.14	0.72	-4.37	3	98	2009-01-15 18:05:59	2008-08-26 16:52:19	3	1	97	2	1	14	0	89.50	99	60.91	CHANGED	NSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY	NSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY....	0	1	1	1
+11267	PF11435	She2p		RNA binding protein She2p	Pollington J	anon	pdb_1xly	Family	She2p is a RNA binding protein which binds to RNA via a helical hairpin. The protein is required for the actin dependent transport of ASH1 mRNA in yeast, a form of mRNP translocation. ASH1 mRNP requires recognition of zip code elements by the RNA binding protein She2p. She2p contains a globular domain consisting of a bundle of five alpha-helices [1].	25.00	25.00	36.30	196.30	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.42	0.71	-4.93	6	29	2009-01-15 18:05:59	2008-08-26 17:02:09	3	1	26	2	17	23	0	208.20	61	83.75	CHANGED	-hlcpllslaSsYISsYlclLNKaIshLRRVSTLRFERsTLIKaVKKLRFaNDsLhoash.......psphshcscsLpcslpslGSaFlKsLEhlDLLNYYLTQsLQsElISKTLNpDLlls--sIssl-DTYsaFVKFoQWhlESLu...lsDsLLslEllQFolKCAlEDslDls-T-sIhLQEVhPVcsppEapsLhtpWpslLssKhut	......-llEQIlsLhS+YLSSYIHlLNKFIuHLRRVuTLRFERTTLIKFVKKLRFYNDslLSYNsp......cs-h-spuDohc.........clllPIAShFlKClEThDLLNYYLTQSLQKEIlSKTLNEDLTLosEoIlAIDDTYNHFVKFoQWMIESLp...IsosLLsLEVVQFAlKCAcEDGT........slsETDNIFLQEllPVsSEEEFpoLostWpuILcuKLss..	0	1	7	14
+11268	PF11436	DUF3199		Protein of unknown function (DUF3199)	Pollington J, Finn RD	anon	pdb_1xn8	Family	Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.	25.00	25.00	25.40	27.60	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.68	0.71	-4.27	6	44	2009-09-10 23:59:37	2008-08-26 17:06:38	3	1	38	2	7	46	0	124.00	47	96.62	CHANGED	.hITP-ELhsYSVaEpVKsRssEhLctDILEAEs-lhplsG+cFoDtch.P.....lPEplRLALL+LAQaaAhhNsDEShhKGapSEKl..GDYSYTlusus.SlsKPDVhtLLtDYl....sphstscs+h+hR	...LIsPs-lhsYSVa.-pVKsRPppLLpQDIlEAEuEhtplsGH.cFsDpsh.P......LP-cl+LALlKLAQYaALl.Nu...D....E...oshcuYpSEKl..GDYSYTlussu..ulpKP-VapLLp-aI....sths.tpsph+hR............	0	2	5	6
+11269	PF11437	Vanabin-2		Vanadium-binding protein 2	Pollington J	anon	pdb_1vfi	Family	The Vanadium binding protein, Vanabin2, contains four alpha-helices connected by nine disulphide bonds. Vanadium accumulates in Ascidians however the biological reason remains unclear [1].	25.00	25.00	39.00	38.40	19.20	18.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-11.94	0.72	-12.75	0.72	-4.00	10	14	2009-01-15 18:05:59	2008-08-26 17:19:14	3	2	3	1	8	11	0	92.40	33	55.68	CHANGED	CtspCposCssl+sC.+tpCtpsCtuspstp......hCp+sCt+spChss.......sCcsChpc.C.ht.hctCRsssCuppCP.t............tKshKsssC+cCMcpNC	..ChspCpssCssl+sC.ptpChpsCtuspp.t......hCp+sChhspC.ss.......sCcpChts.C.ht.hctC+pspCuppCP.t..........t.tpth+sssC+pCMhpNC	0	5	5	8
+11270	PF11438	N36		36-mer N-terminal peptide of the N protein (N36)	Pollington J	anon	pdb_1qfq	Family	The arginine-rich motif of the N protein is involved in transcriptional antitermination of phage lambda. N36 forms a complex with boxB RNA by binding tightly to the major groove of the boxB hairpin via hydrophobic and electrostatic interactions forming a bent alpha helix [1].	25.00	25.00	27.90	36.70	17.60	16.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.82	0.72	-4.44	2	67	2009-01-15 18:05:59	2008-08-26 17:27:41	3	1	62	1	0	41	0	34.90	97	32.86	CHANGED	DAQTRRRERRAEKQAQWKAsp.LhsshptpsspR.	DAQTRRRERRAEKQAQWKAANPLLVGVSAKPVNRP..	0	0	0	0
+11271	PF11439	CesA	DUF3200;	Type III secretion system filament chaperone CesA	Pollington J	anon	pdb_1xou	Family	This family represents a chaperone protein for the type III secretion system - TTSS - translocon protein EspA, to prevent the latter's self-polymerisation. The TTSS is a highly specialised bacterial protein secretory pathway, similar in many ways to the flagellar system, that is essential for the pathogenesis of many Gram-negative bacteria. The twenty or so proteins making up the TTSS apparatus, referred to as the needle complex, allow the injection of virulence proteins (known as effectors) directly into the cytoplasm of the eukaryotic host cells they infect; however, the injection process itself is mediated by a subset of extracellular proteins that are secreted by the needle complex to the bacterial surface and assembled into the type III translocon - EspA. EspB and EspD. EspA polymerises into an extracellular filament, and, as with other fibrous proteins, is apt to undergo massive polymerisation when overexpressed. CesA is the secretion chaperone protein that binds to EspA. CesA is dimeric and helical, and it traps EspA in a monomeric state and inhibits its polymerisation.	25.00	25.00	28.10	140.30	22.90	20.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.30	0.72	-4.06	2	64	2009-11-23 17:28:21	2008-08-27 09:06:07	3	1	63	3	1	15	0	91.60	95	88.57	CHANGED	MsIVpQT+NKELLDKKIRSEIEsIKKIIAEFDVlKEsVN.LSEKAKTsPQAAEpLNKLIEGYTYGEER+LYDSALSKIEKLIEThpPsRStSQ.T	M....SQTRNKELLDKKIRSEIEAIKKIIAEFDVVKESVNELSEKAKTDPQAAEKLNKLIEGYTYGEERKLYDSALSKIEKLIETLSPARSKSQST.	0	0	0	1
+11272	PF11440	AGT		DNA alpha-glucosyltransferase	Pollington J	anon	pdb_1xv5	Family	The T4 bacteriophage of E.coli protects its DNA via two glycosyltransferases which glucosylate 5-hydroxymethyl cytosines (5-HMC) using UDP-glucose. These two proteins are the retaining alpha-glucosyltransferase (AGT) and the inverting beta-glucosyltransferase (BGT). The proteins in this family are AGT. AGT adopts the GT-B fold and binds both the sugar donor and acceptor to the C-terminal domain. There is evidence for a role of AGT in the base-flipping mechanism and for its specific recognition of the acceptor base [1].	25.00	25.00	31.00	30.10	18.90	16.90	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.14	0.70	-5.57	2	14	2009-01-15 18:05:59	2008-08-27 09:18:47	3	1	11	9	1	15	23	335.00	57	79.25	CHANGED	CGVTKFSLEQRDWFIKNGHEVTLVYAKDKSFTRssuHDaKSFSIPVlLAKEYDKsLKLVNDCDILIINSVPATSVpEsTINNYKKllDNIKPSlRVVVYQHDHSsLSLRRNLGLEETVRRADVIFSHSDNGDFNKVLMKEWYPETVSLFDDIEEAPTVYNFQPPMDIsKVRSTYWKDVSEINMNINRWIGRTTTWKGFYQMFDFHEKaLKPAGhSTlMEGLERSPAFIsIKEKGIPYEYYt.+plDphplAPN.PsQILDpYlNSEMLERMSKSGFGYQLSKLspKYLQRSLEYTHLELGACGTIPVFWKSTG-NLKFRVDNTPLTSHDSGIIWFDENDMESTFERIKELSSDRA	.......CGVTKFSLEQRDWFIKNGHEVTLVYAKDKSFTRssAHDaKSFSIPVlLAKEYDKTLKLVN.DCDILIINSVPATSV.EE-.TINNY.KKIIDNIKPSlRVVVYQHDHSsLSLRRNLGLEETVRRADVIFSHSDNGDFNKVLMKEWYPETVSLFDDIEEAPTVYNFQPPMDIsKVRSTYW.KDVSEINMNlNRWIGRTTTWKGFYQMFDFHEK.aLKP.AGhSTIMEGLERS.P.AFIsIKEKGIPYEYYph+plDphKlAPNhP..sQILDpYVNSEMLERMSKSGFG...YQLSKLsKKYLQR...SLEYTHLELGACGTIPVFWKSTGENLKFRVDNTPLhSHDSGIIWFDENDMESTFERIKELSSDRA.................................................................................................................................................................................................................................	0	1	1	1
+11273	PF11441	MxiM		Pilot protein MxiM	Pollington J	anon	pdb_1y9l	Family	MxiM, a Shigella pilot protein, is essential for the assembly and membrane association of the Shigella secretin MxiD. MxiM contains an orthologous secretin component and has a specific binding domain for the acyl chains of bacterial lipids [1]. The C terminal domain of MxiD hinders lipid binding to MxiM [1].	25.00	25.00	259.70	259.40	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.70	0.71	-4.01	2	8	2009-01-15 18:05:59	2008-08-27 11:11:16	3	1	8	3	0	4	0	115.00	99	80.35	CHANGED	uSSNSEKEWHIVPVSKDYFSIPNDLhWSFNTTNKSINVYSKCISGKAVYSFNAGKFMuNFNVKEVDGCFMDAQKIAIDKLFSMLKDGVVLKGNKINDTILIEKDGEVKLKLIRGl	SSSNSEKEWHIVPVSKDYFSIPNDLLWSFNTTNKSINVYSKCISGKAVYSFNAGKFMGNFNVKEVDGCFMDAQKIAIDKLFSMLKDGVVLKGNKINDTILIEKDGEVKLKLIRGI	0	0	0	0
+11274	PF11442	DUF2826		Protein of unknown function (DUF2826)	Gunasekaran P, Mistry J	anon	Pfam-B_001753 (release 23.0)	Family	This is a family of uncharacterised proteins that is highly conserved in Trypanosoma cruzi.	20.20	20.20	22.50	22.50	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.43	0.71	-4.57	2	60	2009-09-11 10:16:18	2008-08-27 11:20:43	3	1	2	0	2	60	0	131.00	79	68.08	CHANGED	pRERtRE.LLL.LASLLPhVASHADYh..ADHGWCASTSDVVCRHFTAPVKHTSRRMLWLWIWCRtCSRHhFARLLFTALR.IDASP.ESFsAAPCVVLstphohll................Csh.LTV.tpsVhhp+s...+pRhasshhtCspaspuphlt	...t..cRERE.LL.LLLAS.LLPFVASHADYCLSADHGWpASTSDVVCRHFTAPVKHTSRRMLWLWlWCRcCSRHYFARLLFTALRQIDASPPESFTAAPCVVLPAQ.ShVVhRLsDupsPLRWsMQGCGLPLTVLGTAVWMR+P...HERMYCGphKCVKYAESQhLQ...	1	0	0	2
+11275	PF11443	DUF2828		Domain of unknown function (DUF2828)	Gunasekaran P, Mistry J	anon	Pfam-B_001814 (release 23.0)	Domain	This is a uncharacterised domain found in eukaryotes and viruses.	29.00	29.00	29.20	29.40	28.00	28.80	hmmbuild  -o /dev/null HMM SEED	534	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.85	0.70	-6.30	19	303	2009-01-15 18:05:59	2008-08-27 11:21:35	3	3	139	0	139	295	228	343.40	21	87.77	CHANGED	TENsusTahoS....ssssLDhFhplss.pss..........cplhsLhttAWs....cDs.hslKllhplRslR.sG+u-+pu...FhpshhaL.tcp..aPpTlttN....................................................hpplspaGha.KDlhpllhphlc.....................................................................................................................................................pshcLauctLtpDhp.lt..tt..............hpplSLAAKWsPo.spphsctshhsptlut..........................hthsccchRK.sLsPLR+tLplsEhhMuA+pWsplsYs+VsSlAMtpYpchFh++DspR.............FptYLpslppGc.......sKlsAuulhPa-llpphhs.sspst......................A-hQWcshscplpppGp..lpNslAlsDVS.....GSMsu............PMcVsluLGLLlSEh..sssPa+sclITFSpsPphcpl..pGc.sLt-+sphlpphsWG.hsTshptVF.-hILpsAlcspLs.-cMl+clFVFSDMEFDpAssttt................................hcTsaEslpc+apcsGYt..lPclVFWNLpsssu...sPVsuscpGVALVSGFStslh+hhLps...........................................phsPhshMh..................................culs	.....................................................................................................................h......t.....t.h...h.....s................h.....................................................................................hGhh.c.h...........................................................................................................................................................................................................................................................huKh...........................................................hpt.....hp....h.-..ht.t...........h..h.a...st.s.........hF..p...t.....................h...a..th..t...................h..t........h...h.............................................................................................................................p.hsh.shs.....tp................h..s.uhshhhst....t..att.hh.att.......h..................t.........h..........thph.tsh.p.ll.........uht..th......t.hhlhoDh.hp.s............................................................t.h...a.t.t.s.......h.........PphlhWslt.............................h........sh.hhsG.s.thht.h.t...........................................................................................	0	40	86	114
+11276	PF11444	DUF2895		Protein of unknown function (DUF2895)	Gunasekaran P, Mistry J	anon	Pfam-B_002001 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.60	22.60	22.80	50.90	21.60	22.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.18	0.71	-5.10	26	239	2009-01-15 18:05:59	2008-08-27 11:22:14	3	3	191	0	62	214	10	196.20	50	89.80	CHANGED	+ptlsspcpHIhoLRlshuhLsllhlshhhuhhpAPpcLslHlPPDLRu.GSTRph.....W-VPspsVYuFuaYIFQQlNRWspsGcpDYtpsIt.tLpsYLTPuCpshLppDhc.RtpsGELppRsRsVa.EIPGRGYusp....+VhlhopcsWsVpLDlsscEhap...uEsVK+sl.lRYPL+VVRhDlDsE+NPaGLAlDCYsus.PpRl	................ptlsptpsHIpTLRlusu...hLsllhlshshGWhpAPccLTIHlPPDLRS.GSTRhW....WEVPPpoVYuFuaYIFQQLNRWPpsGEpDYspNlp.pLusYLTPuCpsaLppDachRpssGELRpRVRslY.EIPGRGYu-s..........+VpshSpcsWhVpLDlsuDEYat........uE.VKRAL.lRYPl+VVRh-lDPppNPFGLALDCYsus.PQRl.................	0	8	29	50
+11277	PF11445	DUF2894		Protein of unknown function (DUF2894)	Gunasekaran P, Mistry J	anon	Pfam-B_001968 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	59.20	59.10	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.78	0.71	-11.41	0.71	-4.05	44	142	2009-01-15 18:05:59	2008-08-27 11:23:51	3	2	136	0	46	157	12	178.40	44	83.45	CHANGED	LDAW....REpGADRLDPVRF+hl-ALpRRAAApsGsARcLLDsRLAsLl-uYAsplpcApsssssspss......................................................sussstPA+GsLAuLlchlu...+p.......A.scpRus..............sth..hsE.c....hL.DY...................FRcT...WS+lss-pQlRQSL-QVP+NAGPLNSSsLVHRSLoLMRELSPcYLpQFLSYVDALSWLEQhsuss	................................L-AWRppGADRlDPVRF+hl-ALt+RAAupsGtsRplL-sRLusLlcuYAttlppstsssts.t...............................................................ss......ssstsspusLusLlp.lu.................u.sthht............................................ssth.hhsE.t....hL.Dh...............................FRco...Wo+lps-pQlRQSL.ppVPcNAGPLNSssLVHRuLsLMRELSPtYLppFLSYVDALuWLEQhsuts.................	0	7	21	34
+11278	PF11446	DUF2897		Protein of unknown function (DUF2897)	Gunasekaran P, Mistry J	anon	Pfam-B_002015 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.70	21.70	22.50	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.79	0.72	-4.14	32	221	2009-01-15 18:05:59	2008-08-27 11:24:52	3	1	220	0	49	148	6	61.10	35	93.54	CHANGED	.shpsWlIIllVlGVIsuNLAsLKaoA+hKhsphsc.hpphppps........t.cppsst-	..........apsWlIlllVluVIVGNlAsLKaTAp.hKhsph.-cppcpsc.pt..........t.........t..............................................	0	7	14	34
+11279	PF11447	DUF3201		Protein of unknown function (DUF3201)	Pollington J	anon	pdb_1yb3	Family	This archaeal family of proteins has no known function.	25.00	25.00	26.60	38.10	24.00	22.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.01	0.71	-4.80	4	14	2009-01-15 18:05:59	2008-08-27 11:29:45	3	1	14	1	12	17	0	150.90	53	88.93	CHANGED	EFLN+hWE-sFcLREEL+EELc..GFcVEEVsEVFNAYLYlDGcWcEMKYPHPAFsl+PGGEVGATPQGFYFVFAFsKE-LocEFlccFlcsFcK.SFIYGhENFLEDFYN...ssPhSh-EVac+IhpScEchINFEVDhshs+EELK+cLh+.F	.....paLN+hWt-lFcLpEELKEELp..GFcVE-VEEVFNAY.IalDGEWccMcYPHPAFplKPtGEVGATPpuaYFVhAlsKEc.loc-FlptFlctF.+.SFIYGuENFLpDhYN..ccsPhsscEVhccIccScEclhpFEsshs.sh-cLKctLh+...............	0	2	2	7
+11280	PF11448	DUF3005		Protein of unknown function (DUF3005)	Gunasekaran P, Mistry J	anon	Pfam-B_3492 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	45.50	45.50	19.40	18.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.45	0.71	-4.47	11	108	2009-01-15 18:05:59	2008-08-27 11:30:58	3	1	68	0	27	98	3	119.10	48	72.35	CHANGED	usssRRAssR.lpLDNssTc..DsTVDTDGKshEAA+hAotht...DplhhSNASLsNAls-ss-G..lAGhDSRPGGNpPtlAhRsGapVlcpGhlsss..........................sspGpRsp+VIplpcs	..........ssstRAtsR.lpLDNssTt..DsTVDTDGKshEAuRhASth....DplhhSNASLsNAhPEssDG..hAGhDSRPGGN+PtlAhRsGatVlccGhssss............................st.s.pRst+llplp.s..	0	2	5	15
+11281	PF11449	DUF2899		Protein of unknown function (DUF2899)	Gunasekaran P, Mistry J	anon	Pfam-B_002023 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	24.40	24.40	25.80	24.50	22.80	24.00	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.94	0.70	-5.24	19	285	2009-01-15 18:05:59	2008-08-27 11:31:55	3	3	211	0	48	243	397	219.80	29	79.21	CHANGED	AAlhGAlPGCGGAllVsotassGpluFGAlVAVLsATMGDAAFLLLAspPpsulh..llsluhllGlloGhlVshhatcch..h+st.tptsttspts........................pthphthh........ha.hlllPuhllulh..tuhpl-hsphh.th.thslthhGshh.uh..hhlWAhop.htshpshsspssth....p....lp+ssp-TsFVosWVlsAFLha-lslthsGl-..LtshatthuhhhPLIullIGLlPGCGPQIlVToLYlsGslPhSulluNuISNDGDALFPAIAluPKuAlhATlYoulPAllVGYGaYal	.............................uullGslPtCGhulhsss.ahpthlshGsllAlhhuT.s-Ah.lllutt..s...hshh..lhslthlhuhlsGhllshh.hht.h...hp............................................................................................................................................................................................................p.p.ptth.......t...htpuh.tcT.hl.salhhshhhhphhhhhhG.-..lss.htthuhh.PhhuhhlGhlPsCusplllTpLY.lpGslshuu.hushlossGsuLhshht.hs.....ct.t.h..hpl..hs...l.....Ahhluhshh...........................................	0	18	29	42
+11282	PF11450	DUF3008		Protein of unknwon function (DUF3008)	Gunasekaran P, Mistry J	anon	Pfam-B_3521 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.50	21.50	22.00	45.70	19.00	18.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.69	0.72	-3.83	21	166	2009-01-15 18:05:59	2008-08-27 11:37:14	3	1	163	0	47	105	274	57.50	69	82.60	CHANGED	AKSKAQQ+AAGAALuAKRG-scpS-L+GAS+pMh-SMSEKELE-hAST++KGKPcHts	.AKSpAQQKAAGAALuAKRGEhKhSELpGASKpMa-SMoEKELEEhApTKRKGhPpHhS........	0	12	24	32
+11284	PF11452	DUF3000		Protein of unknown function (DUF3000)	Gunasekaran P, Mistry J	anon	Pfam-B_3481 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	41.60	41.50	18.10	18.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.02	0.71	-5.03	38	408	2009-01-15 18:05:59	2008-08-27 11:38:31	3	1	407	0	108	282	65	181.80	45	89.57	CHANGED	upPstF+cAVsAMpAsslRPEIcLGsIRPP.QRLAPaSaALGA-Vp....cs-...t.hstpu-ssAFGRLILLaDPsGs-AW-GT.hRLVAYlQADLDss.AsDPLLPEVAWSWLs-ALcuR..ssphsALGGTVTuTTSVRaG-IuGPPcAaQlELRASWTAos.....s.DLuuHVpAFs-VLppsAGLP..PtG....VTcL	..........h.Ps.FppAlpuhpu..s....p...hRs-lcltpI.sP.pRLAPaShA..luu-..Vs.....ts-.................................-s.AhGRLILLHDPsGp-AWp......G........T.hRlVAalpADlDsuhAsDPLLPcVAWSWLsDuL...............-u+.............sss.......apAluGTVTussStpFGsluus.....PcupplElRASWTsss.............................DluuHlpAas-lLtpsAGLP...Psslss...........	0	35	80	100
+11285	PF11453	DUF2950		Protein of unknown function (DUF2950)	Gunasekaran P, Mistry J	anon	Pfam-B_002484 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	20.20	20.20	22.20	23.30	20.00	19.50	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.56	0.70	-5.41	42	260	2009-01-15 18:05:59	2008-08-27 11:39:24	3	3	231	0	69	187	20	245.90	54	89.42	CHANGED	QpsFsoP-tAspAhssAlss..sDpssLtplLGsshccllssss..hsppshtcFlptapppH..pl.tc.....scscAhLtVGsssWshPlPlVKpusG.WpFDstAGpcEllsRRIGRNELsAIpshhAYlDAQp-YApp...ttstshcYAQ+llSosGK+DGLYWssss.GcstSPLGPhhupus.tpsh..........spsYaGYaaRILs.uQGssAsGGthsYllpGphhtGFALlAWPAcYGsTGVhoFhVspcGpVYp+DLG.cTsphApshppFsPD..tsWphV	........................................................................................QppFsoPEsAAsAFusA..lAs..psEspLssLLG-DWRpaLPs-G..sDs-uVsRF.RDW+cuHcIVpc......-ssAaLsVGc-sWpLPlPhVKcssG.W+FDhAAussEILTRpIGRNELuslQAh+AYVDAQpDYhhp.......sp+aApRIISS-GpKDGLYWPocs..G.-...........sPSPLGPsFSsAu.................ss-GYHGY+FRIlo.spssc...................GhALlAWPh+YG-TGVMSFMVNQDcclYQuDLGc-Tcu+spAITcFsPD..spWQs..............	1	12	25	46
+11286	PF11454	DUF3016		Protein of unknown function (DUF3016)	Gunasekaran P, Mistry J	anon	Pfam-B_3517 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	27.30	73.70	23.20	19.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.70	0.71	-4.60	32	121	2009-01-15 18:05:59	2008-08-27 11:41:40	3	2	116	0	55	121	21	139.00	37	77.50	CHANGED	sG....tVpVpapcPcpapDlc.tusthpsphcpphhppLscplschAp+hLsssQpLclplTDlDLAGchcP......ttss.s-lRlV+-laPPRIshsYpLh.psGpVltp.Gcc+LsDhuF.hppsshhss...csh.tYE+phLsDWhccp	..............G.VpVpWp-PppFpDl+..osptpsthcpchhppLspphpc.As+.LssGQpLclslTDlDLAGchcP...........htusshsDlRlV+.DIYP.PRIshsYpLh.tsG+Vltp.G-c+LsDhuF....h.s.hs..thss...-sh.tYEKphLsDWh+cp..	0	13	29	42
+11287	PF11455	DUF3018		Protein  of unknown function (DUF3018)	Gunasekaran P, Mistry J	anon	Pfam-B_3532 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	21.30	21.30	21.40	21.80	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.16	0.72	-4.04	24	130	2009-01-15 18:05:59	2008-08-27 11:42:13	3	1	117	0	50	103	9	63.50	43	76.54	CHANGED	stpRV++HR-+LRstGLRPVQIWVP.DsRsPpFtsEsRRQsthlsp.-tp-sclhtFl-cs.sDh.......-sW	.........s.ppRVp+aR-pLRttGLRPlQIWVP.DsRpPcFstEs+RQutLVAt.ctt-s-..sFlDts..sDh.-s........................	0	10	21	37
+11288	PF11456	DUF3019		Protein of unknown function (DUF3019)	Gunasekaran P, Mistry J	anon	Pfam-B_3539 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	25.00	25.00	50.70	50.60	24.20	19.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.55	0.72	-3.70	30	88	2009-01-15 18:05:59	2008-08-27 11:47:29	3	1	49	0	36	69	8	100.50	29	77.97	CHANGED	LploPchCls.ccupsCphslplpWQsss.tshClh.sppsh.hhCapssppsphslphcsspslpFhLhcpcssps....LAssplcVs.s..hpsR+RhRssWsL	..hploPchCls.ccspsCphslplpWQtspstphClh.sppph.hhCapstpptphshphcsppshpFsLl....s.pcsspsLApsclcVs.s..hpsR++hRssWsL...	0	4	13	24
+11289	PF11457	DUF3021		Protein of unknown function (DUF3021)	Gunasekaran P, Mistry J	anon	Pfam-B_3526 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	23.10	23.10	23.10	23.20	23.00	22.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.96	0.71	-4.28	33	949	2009-01-15 18:05:59	2008-08-27 11:48:11	3	2	811	0	85	479	2	136.00	30	95.57	CHANGED	M.....h+phlptshhGlslGhhl.llhhhh.ts.....psshss..p.hlshh....................llGhlhuhhohIFcp..-chSlhtphlhHFhsshhshhshshlss.Wh.ht...shlhhhlh..Fl.llYllIWhhhahphppclc+INppL	.................................................M.....Kphhp.s.hh..h....G.lhIGhhls....llhs..hlhsst.....hs.hsshos.........hhp.hh......................hIGhlash.us.hlFch....pc.aS...h.hp.t...slhHFhlh...hssals...l...uhlsG.WF.Phph....hhlhhhlh..Fl.llY.ll.IW.hIhahpptpplcpINp.L..............	0	17	41	63
+11290	PF11458	Mistic		Membrane-integrating protein Mistic	Pollington J	anon	pdb_1ygm	Family	Mistic is an integral membrane protein that folds autonomously into the membrane [1].The protein forms a helical bundle with a polar lipid-facing surface. Mistic can be used for high-level production of other membrane proteins in their native conformations [1].	22.30	22.30	22.40	134.60	20.30	18.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.58	0.72	-3.58	3	23	2009-01-15 18:05:59	2008-08-27 11:50:52	3	1	23	0	3	19	0	84.00	77	88.55	CHANGED	MKVTDQEKEQLSsAID+MNEGLDsFIpLYNESEKDEPLIQLEDETAELl+cApEpYGp-clNpKLNAIIKEILS.lSLc--GcEc	MKVTspEKEQLSsAIDRMNEGLDAFIQLYNESEhDEPLIQh-D-TAELh+QARD.YGQEpLNEKLNTIIKQILS.ISLScEGcc....	0	1	1	2
+11291	PF11459	DUF2893		Protein of unknwon function (DUF2893)	Gunasekaran P, Mistry J	anon	Pfam-B_001947 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.00	22.00	23.60	38.50	20.70	19.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.01	0.72	-4.18	32	244	2009-01-15 18:05:59	2008-08-27 11:53:01	3	2	227	0	72	189	24	65.70	41	26.50	CHANGED	SsPERAlLEhLsclscppoh.ccscplhpGLssLRPchLppLLppCpulKspRLFhhhAcctsHsWtp+L	........SsPEhAhhEllssls....pthSF.EcsspLhpGLssLpPctlppLLppspSVpspRLFLahAchhsHtWhpcl......	0	13	39	62
+11292	PF11460	DUF3007		Protein of unknown function (DUF3007)	Gunasekaran P, Mistry J	anon	Pfam-B_3514 (release 23.0)	Family	This is a family of uncharacterised proteins found in bacteria and eukaryotes.	25.00	25.00	33.60	40.10	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.21	0.72	-3.95	30	109	2009-01-15 18:05:59	2008-08-27 11:58:10	3	1	100	0	54	107	95	98.30	43	74.84	CHANGED	MsRhcVlh....IGlulhllGGluYhshp.hhGl-uhsAGIhupulLVlsl.luWsuSYla..RVloGcMTahpQR+cYccsa............LQcRh-uLosEEhptLht-lpp	.MpRhDVlh....IGlGlhlhGslhYhsLp.hhGlDuhpAGhhuQs.lLVlG.l.luWluoYlF..RVsspcMTYtpQh+-YEcth............lpKRl-pLo.-ElptL.t-lE..........................	0	16	38	50
+11293	PF11461	RILP		Rab interacting lysosomal protein	Pollington J	anon	pdb_1yhn	Family	RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes [1].	21.20	21.20	21.30	21.30	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.03	0.72	-3.82	14	188	2009-01-15 18:05:59	2008-08-27 12:46:05	3	2	72	1	109	162	0	59.20	43	18.62	CHANGED	TLQELR-VLpERNcLKuplhllQEELthY+st.hppcpt......sss..t.....t.hsphppEsst+	...TLQELR-VLpERNELKuplhlLQEELthYK..s.....p.hppcpt............st....h.....p.hsp.p.tp.................................	0	21	29	59
+11294	PF11462	DUF3203		Protein of unknown function (DUF3203)	Pollington J	anon	pdb_1ywy	Family	This family of proteins with unknown function appears to be restricted to Gammaproteobacteria.	25.00	25.00	87.60	87.40	20.00	17.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.28	0.72	-4.07	5	34	2009-01-15 18:05:59	2008-08-27 13:11:16	3	1	34	1	9	28	1	74.00	55	97.07	CHANGED	Msl-IDs...sopsCslslEss+c+usssslcItTDuEtRMSVlsl-GcRlaITEsEADALTVAGAsDuRRHLKADD	MoIEIDs...ppthColplEGsRc+u..sls..sl+IsTDsEtRhSVlhlDGcRlaIoEp-AptLsVAGApDpRRHLhADD.	0	2	2	7
+11295	PF11463	R-HINP1I		R.HinP1I restriction endonuclease	Pollington J	anon	pdb_1ynm	Family	Hinp1I is a type II restriction endonuclease, recognising and cleaving a palindromic tetranucleotide sequence (G/CGC) resulting in 2 nt 5' overhanging ends [1]. HINP1I has a conserved catalytic core domain containing an active site motif SDC18QXK and a DNA-binding domain [1].	25.00	25.00	27.40	27.00	23.00	22.40	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.22	0.71	-4.92	3	24	2012-10-11 20:44:46	2008-08-27 13:12:27	3	1	23	6	3	21	5	187.10	54	83.72	CHANGED	MGYDL-cIEpVKAsVLSG.YKADVNVlILVphK..csLDlcNIQVKLVSNp+GFNQIDKRWL+oYQEMWNFPcNIYcILpYFTGELcPp+pcsK.DKRRMFhsEFSQEEQsclLDWL--NKlLILoDILKGRG-FAAEWVLVIQKlsNNh+WlLKNINEVlQHY.suG-VplSP+GSLKIGRVTIQRKGGDNGRESANMLQFKIDPTcLL	...............MGYsLspIcpVKAslLsG.YKADINl.lhlhhK..pslDlcNIQVKLVS.N.p+GFNQIDKRWlKsYpEhWphscsIhplLpYFTGELp......t.sp+RhhhsEFoppEQ.hlLsWFppNKlLlLoDIL+GRG.-FuAEWhLVhQ.Klsp.N.+WsLKNINEVlQHY..ssG-V.ISP+GSL.KIG+...lThQRKGGDNGR.oANMLQFKIDPsELh.......................	0	1	2	3
+11296	PF11464	Rbsn		Rabenosyn Rab binding domain	Pollington J	anon	pdb_1yzm	Domain	Rabenosyn-5 (Rbsn) is a multivalent effector with interacts with the Rab family.Rsbn contains distinct Rab4 and Rab5 binding sites within residues 264-500 and 627-784 respectively [1]. Rab proteins are GTPases involved in the regulation of all stages of membrane trafficking [1].	20.60	20.60	20.80	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.88	0.72	-4.39	6	155	2009-01-15 18:05:59	2008-08-27 14:31:52	3	5	98	4	111	146	0	41.40	48	9.63	CHANGED	LLQQIsNI+uYI+QA+tutRhDEVcsLpcNLRELQcEhtcQQ	.........LLQQIpNIcuaIcpA+pssRhDEVcsLpcNLRELpcchtpQp......	0	25	38	74
+11297	PF11465	Receptor_2B4		Natural killer cell receptor 2B4	Pollington J	anon	pdb_1z2k	Domain	2B4 is a transmembrane receptor which is expressed primarily on natural killer cells. It plays a role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells in a subset of CD8 T cells [1]. The structure of 2B4 consists of an immunoglobulin variable domain fold and contains two beta-sheets. One of the beta-sheets, the six-stranded sheet, contains structural features that may have a role in ligand recognition and receptor function [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.05	0.72	-10.36	0.72	-4.13	4	44	2012-10-03 02:52:13	2008-08-27 14:39:07	3	2	25	6	18	121	0	106.40	44	31.50	CHANGED	CsDSuEEVVGVSGKPVpLRPSNIQTKcVSlpWKKph..SHsphc.IlsWsNsuspssshsSSDIYGF-scsFALSIKSAQLQDSGHYLLElTspsGpVCTKNFQlLIhD	........................C.sSu-cVVulSGpPlpLp.Ps..slQTK.h.h.S..lpWKhph.....Spsphc.I..LpW.cNsus...sp........s...s............s...c....pau..F.p....hc....shuL.....IKuAQ.QDSGhYhLElTs.psGpV.pstpFQV.lFD................	0	1	1	3
+11298	PF11466	Doppel		Prion-like protein Doppel	Pollington J	anon	pdb_1z65	Family	Dpl is a homologue related to the prion protein (PrP). Dpl is toxic to neurons and is expressed in the brains of mice that do not express PrP. In DHPC and SDS micelles, Dpl shoes about 40% alpha-helical structure however in aqueous solution it consists of a random coil. The alpha helical segment can adopt a transmembrane localisation also in a membrane [1]. The unprocessed Dpl protein is thought to posses a possible channel formation mechanism which may be related to toxicity through direct interaction with cell membranes and damage to the cell membrane [1].	25.00	25.00	27.40	27.40	18.20	17.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.19	0.72	-7.10	0.72	-4.38	7	74	2009-09-11 05:32:31	2008-08-27 15:40:05	3	1	51	1	14	79	0	29.70	73	16.75	CHANGED	MRKHLGshWLAllChLLhScLSsVpARGIK	....MRKHLGGCWLAIVCVLLFSpLSuVKARGIK	0	1	1	2
+11299	PF11467	LEDGF		Lens epithelium-derived growth factor (LEDGF) 	Pollington J	anon	pdb_1z9e	Family	LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure [1].	24.00	24.00	24.30	24.80	23.50	23.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.24	0.72	-4.34	9	180	2009-01-15 18:05:59	2008-08-27 15:40:40	3	4	78	27	106	162	0	106.50	42	20.50	CHANGED	EccLQ+LHsEIK.uLKlcssDlcKClcAL-ElusLpVTophLQKNs-slsTLKKIRRYKus..................QslMcKAstlYs+FKshFl.scsEohhshs.phsppEpc.p-pscp	.........-p+LQ+lHu-IK.uLKlDssDVp+CLpAL-ELusL..QVTpQhLQKpo-hlsTL.KK......IRRaKus.......................................p.slM-KAshlYs+aKshFLhscs-sh.st..shs.ts.t-pttcc.t..p.....................	0	19	25	69
+11300	PF11468	PTase_Orf2		Aromatic prenyltransferase Orf2	Pollington J	anon	pdb_1zb6	Family	In vivo Orf2 attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during naphterpin biosynthesis [1]. In vitro, Orf2 catalyses carbon-carbon based and carbon-oxygen based prenylation of hydroxyl-containing aromatic acceptors of synthetic, microbial and plant origin [1].	22.00	22.00	175.70	175.40	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.80	0.70	-5.20	12	25	2009-01-15 18:05:59	2008-08-27 16:02:56	3	1	21	8	8	28	0	292.20	28	93.44	CHANGED	hDhp+hhuslctsAthlssPhu+cpshslLssFp-sFsp..Gslla+sss..phssplsYRahs..sh.DshuhAlstGLl.scssHPlssLlschssLhs.ssp.usDhssstGhpKhWsaFss..hpsluclhulPuhPtulttptchFtchGL.-+VphlulDYpp+ThNlYF....tutGslstppstuhh+.sGhssPup....thltaspc.....uaslhsTLsa-oucI-Rlsahshph...sssphPA.lpsclc+F...lcssP.t..tph...shuhsausptcYlKhps.Yphshsphhsh.s.tshs	...hshschhuslccsAthlssshu+cpVhslLssFp-sFsp..uV.lhaRsTo..psscsLsaRFh.s..ssh.DPhuhAlspGLl.scssHPlusLls-lpshhP.hsttulDFulspGhpKsWsaFss..hpsluclhulPuhPtultsptchFt+aGL.-+VphlulDYpp+ThNlYF.......hssGshstcslpuhlp-sGhs...sPop....phlthspc.....uaslYsTlsWDSscIcRlsasshsh...sst...slPupl..pspl-+F...scsAPhtspscp..hlhuhuhus....pscYhKlps.Yphp.h.h.........s..............	0	2	4	7
+11301	PF11469	Ribonucleas_3_2	DUF3204;	Ribonuclease III	Pollington J	anon	pdb_1ztd	Family	This is a family of archaeal ribonuclease_III proteins.	25.00	25.00	155.20	155.00	23.90	17.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.47	0.71	-3.90	3	14	2012-10-03 08:45:47	2008-08-28 09:06:36	3	1	14	2	12	17	0	118.40	62	88.42	CHANGED	KGLAKLGDSLINFLaSLALTEaLGKPTG-RVPNASLAIAL-hoGLSKll+PRsDKHAKGDhAEALlAYAWLcGpISpEEAVEILppNLss-VhcFoRKKEsIG+ALAsLh-hIuERLsuc	KGLuKFGDSLlNFlaSLALoEaLG+PTGsRVPNASLAIAL-hAGLp+hl.PRsDKHGKGDhAEAlIAYAWLEGtITlEEAVEIl+pNhopDVhcFSRKKEAIGpAhA.LL+lIuERLs..h.	0	2	2	7
+11302	PF11470	TUG-UBL1	TUG;	GLUT4 regulating protein TUG	Pollington J	anon	pdb_2al3	Family	TUG is a GLUT4 regulating protein and functions to retain membrane vesicles containing GLUT4 intracellularly. TUG releases the GLUT4 containing vesicles to the cellular exocytic machinery in response to insulin stimulation which allows translocation to the plasma membrane [1]. TUG has an N-terminal ubiquitin-like domain (UBL1) which in similar proteins appears to participate in protein-protein interactions [1]. The region does have a area of negative electrostatic potential and increased backbone motility which leads to suggestions of a potential protein-protein interaction site [1].	23.30	23.30	23.30	24.30	23.20	22.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.69	0.72	-4.05	28	216	2012-10-03 10:59:06	2008-08-28 09:53:01	3	9	197	1	158	213	3	62.90	38	12.64	CHANGED	sls.ss+ptplKVosusslppVLppuCcKaslcss.....casLp+ps.Kh....lDLSLsaRhusLsssu+LEL	...........slssstRRtplKVoPsp.hLhpVLp-u..CpKhs..lsss.......pasLK..app..Kh....l.DLSlsaRhusLsssA+LEl......	0	41	75	126
+11303	PF11471	Sugarporin_N	DUF3205;	Maltoporin periplasmic N-terminal extension	Pollington J, Coggill P	anon	manual	Domain	This domain would appear to be the periplasmic, N-terminal extension of the outer membrane maltoporins, Pfam:PF02264, LamB.	21.60	21.60	21.60	21.60	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.00	0.72	-4.32	19	821	2009-01-15 18:05:59	2008-08-28 09:54:01	3	6	505	0	61	363	7	58.20	36	11.80	CHANGED	Mp.phh.lslhslLhhssh.....tAhAstLTlEQRLtLLEccLppscpELppscpchpc.hcp	..................pp..luhhlhL.hssss....shpu.hA.p...p.L..T......lEQRLtLLEpcLppsc.pchpcscsch+p.hh.p......................	0	4	15	34
+11304	PF11472	DUF3206		Protein of unknown function (DUF3206)	Pollington J	anon	pdb_2au5	Family	This bacterial family of proteins has no known function.	23.60	23.60	23.60	243.30	22.70	23.50	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.73	0.71	-4.36	2	13	2009-01-15 18:05:59	2008-08-28 09:57:28	3	1	13	1	2	3	0	128.00	91	94.76	CHANGED	IlSTpKtPNFpYp-.hcpFL.NhLAFohGhhTtDhSpFsP.VLt.MEc-PsWLpEusuhhQullVtSLl-stNassstpLhsEhspLlpLY.thtpcpLTpNp-sLalslaDKFhhLLLssDEhIh.L	IISTNKAPNFQYTDEMDRFLMNTLAFSVGLVTEDYSTFDPEVLKIMEEEPDWLQESVAWCQSLVVGSLVDSGNYDDTGELMDEFNCLLNLYDRARQRELTSNEDNLFLNIHDKFLALLLTDDELITNL	0	1	2	2
+11305	PF11473	B2		RNA binding protein B2	Pollington J	anon	pdb_2az0	Family	B2 is expressed by the insect Flock House virus (FHV) as a counter-defense mechanism against antiviral RNA silencing during infection. In vitro, B2 binds to dsRNA as a dimer and inhibits the cleavage of it by Dicer. B2 blocks cleavage of the FHV genome by Dicer and also the incorporation of FHV small interfering RNAs into the RNA-induced silencing complex [1].	20.50	20.50	20.70	21.20	20.40	19.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.56	0.72	-4.39	2	10	2009-09-11 16:34:22	2008-08-28 09:58:13	3	1	6	6	0	12	0	74.50	55	62.45	CHANGED	M.SKLALIQELPDRIQpAVEsshuMSYQ-APNNVRRDLDNLpACLNKAK.TVsRMVTSLL-KPShsAYLEGKs	............SphtLlQ-LPc...pIQpAVcsAhuhshpssPspVt+DLDNh+ACLsKhctTshRhssSLLsKPpVVAhLcGcA..	0	0	0	0
+11306	PF11474	N-Term_TEN		Telomerase reverse transcriptase TEN domain	Pollington J	anon	pdb_2b2a	Family	This is the N terminal domain of the protein telomerase reverse transcriptase called TEN. The TEN domain is able to bind both RNA and telomeric DNA and contributes towards telomerase catalysis. The TEN domain has a structure that consists of a core beta sheet surrounded by seven alpha helices and a short beta hairpin [1].	25.00	25.00	417.10	417.10	19.70	18.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.42	0.71	-4.91	2	2	2009-09-11 09:41:36	2008-08-28 10:51:22	3	1	2	3	1	3	0	188.00	100	16.91	CHANGED	INNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNN	INNINNNKQMLTRKEDLLTVLKQISALKYVSNLYEFLLATEKIVQTSELDTQFQEFLTTTIIASEQNLVENYKQKYNQPNFSQLTIKQVIDDSIILLGNKQNYVQQIGTTTIGFYVEYENINLSRQTLYSSNFRNLLNIFGEEDFKYFLIDFLVFTKVEQNGYLQVAGVCLNQYFSVQVKQKKWYKNN	0	1	1	1
+11307	PF11475	VP_N-CPKC		Virion protein N terminal domain 	Pollington J	anon	pdb_2bai	Family	This is the N terminal domain of a family of virion proteins which contains a zinc finger domain. Currently no function is known.	21.10	21.10	81.60	80.60	20.50	17.00	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.72	0.72	-4.41	5	30	2009-01-15 18:05:59	2008-08-28 11:34:25	3	2	7	1	0	33	0	32.00	93	1.67	CHANGED	MATTMEQEICAHSLTFEECPKCSALQYRNGFY	MATTMEQEhCAHSLTFEECPKCSALQYRNGFY	0	0	0	0
+11308	PF11476	TgMIC1		Toxoplasma gondii micronemal protein 1 TgMIC1	Pollington J	anon	pdb_2bvb	Family	TgMIC1 is released as part of a complex by Toxoplasma gondii prior to invasion. The complex which consists of TgMIC4-MIC1-MIC6 participates in host cell attachment and penetration and is critical in invasion. This is the C terminal domain of TgMIC1 which has a Galectin-like fold which interacts with and stabilises TgMIC6 providing a mechanism for an exit from the early secretory compartments and trafficking of the complex to micronemes [1].	25.00	25.00	29.50	252.00	19.10	17.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.57	0.71	-4.64	2	5	2009-01-15 18:05:59	2008-08-28 11:35:37	3	1	3	2	3	5	0	137.00	66	29.94	CHANGED	chclhGDShpAhLctGQQLhlTa.SspLcVuVGSCHpLssNF.DhaLpFpTsSpSu.D.VEl--sAGsu.LTIGLGppGRlsVVhpYsp.suu.t.sAYsVtDSGCpo.EtV.hpGlssGApLVhsTlG-sssu.St	KTEIHGDSTKATLEEGQQLTLTFISTKLDVAVGSCHSLVANFLDGFLKFQTGSNSAFDVVEVEEPAGPAVLTIGLGHKGRLAVVLDYTRLNAALGSAAYVVEDSGCSSSEEVSFQGVGSGATLVVTTLGESPTAVSA	0	2	2	3
+11309	PF11477	PM0188		Sialyltransferase PMO188	Pollington J	anon	pdb_2c83	Family	PMO188 is a sialyltransferase from P.multocida. It transfers sialic acid from cytidine 5'-monophosphonuraminic acid to an acceptor sugar [1]. It has important catalytic residues such as Asp141, His311, Glu338, Ser355 and Ser356 [1].	25.00	25.00	28.50	39.90	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	381	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.21	0.70	-5.64	4	21	2009-01-15 18:05:59	2008-08-28 11:52:36	3	3	19	18	3	32	0	347.70	37	81.47	CHANGED	TlElYlDhAoLPoLpQhhchIQpp--h.ss.RlhuhuRasIssshlsc..hNhpFa..hsN+spstllstL.DphstspphhplplahNhhHulsll.sIhshh.pt.cKloh.cLsLYDDGStEYVsLaphpchs-hppp..Iptpcs.LtphLssspsphsNshhsRYsWpplasopYHhLptDaF-pp..LpsLKchLupshppMcWstasphsspQpshahsllGFssEh.ppQhhts.pssFIFTGTToasus.-hh-hhAQQQlslLNctppssSshalG..psYcLaFKGHPsushlNchIhsph.shIpIPApIsFElLhMTshLPDpVGGhASSlYFolPs-plN+llFhoSDp.p.+p-hLsss....LlpVMlpLsIlsEs	............................................lplYlD.AoLPsLpQhhchhpppc-h.pp.RlhuhuRatls-s.lpp...Nh.phh.hhsN+ss.....ptLhshl.cphsts...lplclahNhuHShplltPIhthh.pths+lpIppLsLYDDGShEYVcL.p.pcstshptp.............lptucppLpphL.ssp.phsN.shhspYsWpphaPspYHhLppDYF-pt..LpsL+cYLupshppMcWssapp..LospQpshahslVGFs.sEh..pphhpsppssFIFTGTToapus.c.h-hhAQQQlNllNchhptpushalG..spYclaFKGHPp..uu.lNchIhssh.shhpIPApIsFElLhMTGh.LPDpVGGlASSLYFSlPpE.KlsaIlFToscp.p.+cDhLpss....hlpVMhpLsIlccp.........	0	0	1	2
+11310	PF11478	Tachystatin_B		Antimicrobial chitin binding protein tachystatin B	Pollington J	anon	pdb_2dcv	Family	Tachystatin B is an antimicrobial chitin binding peptide and consists of two isotopes B1 and B2.Both structures contain a short antiparallel beta sheet with an inhibitory cysteine knot motif. Tyr(14) and Arg(17) are thought to be the essential residues for chitin binding [1].	25.00	25.00	106.00	105.90	18.70	18.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.35	0.72	-4.23	2	2	2012-10-01 22:06:18	2008-08-29 08:54:07	3	1	1	2	0	2	0	42.00	95	100.00	CHANGED	YloCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF	YloCLFRGARCRVYSGRSCCFGYYCRRDFPGSIFGTCSRRNF	0	0	0	0
+11311	PF11479	Suppressor_P21		RNA silencing suppressor P21	Pollington J	anon	pdb_2cwo	Family	P21 is produced by Beet yellows virus to suppress the antiviral silencing response mounted by the host. P21 acts by binding directly to siRNA which is a mediator in the process. P21 has an octameric ring structure with a large central cavity [1]. 	28.90	28.90	29.00	351.60	21.10	28.80	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.10	0.71	-4.53	2	5	2009-01-15 18:05:59	2008-08-29 08:55:10	3	1	2	4	0	6	0	173.80	91	100.00	CHANGED	MKFFhpDGETSRAlSRSESLLRRVKELGTNS.QSElSEClsEFNELApFNHLLVTVEHREWMEpHPpQSScLRsPSRlGEMLKEIRAFLKVRVVTPMHKETAS-TLNAFL-EYCRIsGLsREDALREKMRKV+SsVLFHHSELLKFEVTENMFSaTELLKLNLSLRVISSQILGhAl	MKFFhpDGETSRAISRSESLLRRVKELGTNSPQSEVSECINEFNELARFNHLLVTVEHREWMEKHPKQSSELRsPSRLGEMLKEIRAFLKVRVVTPMHKETASETLNAFLEEYCRITGLTREDALREKMRKVRSTVLFHHSELLKFEVTENMFSFTELLKLNLSLRVISSQILGIAV	0	0	0	0
+11312	PF11480	ImmE5		Colicin-E5 Imm protein	Pollington J	anon	pdb_2dfx	Family	Imms bind specifically to cognate colicins in order to protect their host cells [1]. Imm-E5 is a specific inhibitor protein of colicin E5. It binds to E5 C-terminal ribonuclease domain (CRD) to prevent cell death. The binding mode of E5-CRD and Imm-E5 mimics that of mRNA and tRNA suggesting an evolutionary pathway from the RNA-RNA interaction through the RNA-protein interaction of tRNA/E5-CRD [1].	25.00	25.00	31.30	31.30	20.60	17.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.64	0.72	-4.16	5	26	2009-01-15 18:05:59	2008-08-29 08:55:51	3	1	21	2	5	23	0	78.30	50	81.21	CHANGED	MKLSsKAAIEVCpcAAK+GLsIu+IEGGIWHpP..GFEARlDsIWDGhDsPlDh.oclscNNppAtEsI+-D.SsGHDAFIVTlsu	..........MKLSsKAAIEVCpcAsK+GLhIhtI-GGhWhsP..GFchc.ss.Ws..hD.P.ch..splscNNplAhEsI+-DhpsGasAFIlTlt...	0	0	2	4
+11314	PF11482	DUF3208		Protein of unknown function (DUF3208)	Pollington J	anon	pdb_2ebe	Family	This bacterial family of proteins has no known function.	25.00	25.00	104.60	104.30	16.80	16.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.52	0.72	-3.92	4	19	2009-01-15 18:05:59	2008-08-29 09:07:12	3	1	19	6	13	20	2	107.40	58	95.15	CHANGED	htAVRLhQGYLWHP+uhslDLcuhLPtEls..........sA+lLWDpVsPPhsFFEsGpPTtoQpFYQhTlLhlh-E.P..EuL+s.AEtAupALG.lLEGhPPGVGW.LhEDLRsL	....hpAVRLhQGYLWHP+-hslDLcshLPtEls...........sA+lLhDpVsPPhsFFEDGTPTtoQpFYQlTlLhls--tP..-uL+PhAptsupuLsslLEuhPsGVGW.LhEDLRsL.	0	3	8	13
+11315	PF11483	DUF3209		Protein of unknown function (DUF3209)	Pollington J	anon	pdb_2ehw	Family	This family of proteins has no known function.	25.00	25.00	25.70	82.10	23.90	22.20	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.55	0.71	-3.78	5	29	2009-09-11 16:33:41	2008-08-29 10:10:54	3	1	29	4	14	28	0	122.20	47	99.94	CHANGED	MoCHEIEALRLGLMNVLGTsD-uARpHAccELEGcL..cGPIEALAEA-oLAAlcRHLDAALVDLEEElAAT-c--PEYDYLRGRLVAVRDAEpALpRLsscGEAlLsDLGEoHcsLHEsFPVDE	MuCaElpALRLGlMNlLGhcD-ssppHtcpELtstL....pGPIcuLA-AcoLsulpRaL-uALlDLEEclAst-s-DPchsYhRGhLlAV+csEtpLppLptpu-ulhcDLsEhHchLHEhFPscc.	0	4	10	13
+11317	PF11485	DUF3211		Protein of unknown function (DUF3211)	Pollington J	anon	pdb_2ejx	Family	This archaeal family of proteins has no known function.	21.60	21.60	22.30	22.80	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.62	0.71	-4.13	11	43	2012-10-02 19:24:03	2008-08-29 10:24:31	3	1	17	1	16	38	2	130.40	35	98.28	CHANGED	M.chplpIpTsH-h-ulhpILSDPpFslPplhPshKplp.hpssoFpu.Gc....ahhhsach+Gslalu.sclsYsaplsss.................sstGsG+Lphsh.ppsclplplEY-GhhE+h.u.shlc+hlpchtccl-EcIRhERIKRKI	....M..phsh.TpHDhpslhcILSDP.Fhl.tlLss.cplp.spsspFcs.ss.....huhhsllhpGshYlGss.ploYshphttt...................ssuG+lphph.pcs...cIplhl.-a-Ghhtphst.hhlpp+lpchhcph-EclRLERIKRKI....................................................................	0	2	2	14
+11318	PF11486	DUF3212		Protein of unknown function (DUF3212)	Pollington J	anon	pdb_2euc	Family	Members in this family of proteins are annotated as YfmB however currently no function for this protein is known.	21.50	21.50	24.40	23.40	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.69	0.71	-4.35	4	24	2009-09-10 16:55:32	2008-08-29 10:36:29	3	1	24	2	5	22	0	116.00	57	76.49	CHANGED	MaYFSPEQQaNAWlVSDLVKQlFp+cstppssh+cLssFAEc+F+IsIDaVFSIIhNIGDIEp.hlsp-hEchLSSYLssLhPaVTtDMhcsS+pNAppYL.+E+ssDVY+LFhs.sshhph	.........hpYFSPEQQaNAWlVSDLVKQlF+++stCssGI+ELssFAE-+FHIsIDFVFSIIhNIGDIE..sLspEIEspLSoYLouLhPhlTADMhcoSKsNAatYLp+E+ss-lY+LFh..sshhph	0	1	2	3
+11319	PF11487	RestrictionSfiI		Type II restriction enzyme SfiI	Pollington J	anon	pdb_2ezv	Family	SfiI is a restriction enzyme that can cleave two DNA sites simultaneously to leave 3-base 3' overhangs. It acts as a homo-tetramer and recognises a specific eight base-paid palindromic DNA sequence. After binding two copies of its recognition sequence, SfiI becomes activated leading to cleavage of all four DNA strands. The structure of SfiI consists of a central twisted beta-sheet surrounded by alpha-helices.	25.00	25.00	206.60	206.30	18.30	17.30	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.74	0.70	-5.22	2	6	2012-10-11 20:44:46	2008-08-29 10:52:14	3	1	6	4	3	7	0	235.80	54	95.61	CHANGED	hcpcYhc.s.-clEplEKpTLRhlVQAl.pYppcAppIFEppss.sSs....luEDITp.ALEhhtha.IspRhhGhIDYKpspaL.pPchhl.QsLhVDuKAppttsps.TLQhSQlsM..chRpppSGcslshputl.P...L.phNDs...hlTToIFV+a.YR....VpuR.+ELpSIhVhulPpuhLpppYNPDsssohahAG+cuPsRtEhhRlRl.FDRLKctssWRlQ.l.hssDs.a....W..........st	..........LppsL-+LEEIEKsTLRLVVQAIYDYRcpAlEIF+cEuDLsSD....IuEDITREALDRLGMsRIDpRLFGKlDYKRACYLFHPDYAl+QALFVDSKAEKsuspu.ATLQhSQLSM..tV+QpRSGpsVslpGchPT...lIolcsp..+YLTTTlFVKYNYcc....-uts+pLKSIlVAAVPNGhLQDRYNPsPpDTIWtAGRNAPohGE-FRVRLSFSpLKcKAAWRVQsIPMPP-s.a.....................	0	2	3	3
+11320	PF11488	Lge1		Transcriptional regulatory protein LGE1	Wood V, Coggill P	anon	Charwan C	Family	This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B.  This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters [1]. In S. pombe the equivalent protein to Lge1 appears to be Shf1.	21.80	21.80	21.80	22.20	21.10	21.30	hmmbuild  --amino -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.64	0.72	-3.79	20	157	2009-01-15 18:05:59	2008-08-29 11:04:03	3	1	85	0	81	150	0	100.90	37	32.56	CHANGED	sPal.............tlhplc.............Dpspppc..............lcptap-hs......plDpcLcpLptphh+hE.hphshLpspsp+-uLpVQLT.pEK........L-shhhh	...........................................................................................................................s.ah..............h.ch-ttsp............Dpsppsc.....................lpsRsKAIs......oKsKEIEpVY+QcsETFGMVVKMLlcKDPsLE+sIQhsLcpN........L-Elhh.....................	0	7	20	48
+11321	PF11489	DUF3210		Protein of unknown function (DUF3210)	Wood V, Coggill P	anon	Charwan C	Family	This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is Swiss:O94497 and the Saccharomyces cerevisiae member is Swiss:P40563.	17.50	17.50	22.90	20.60	17.00	16.60	hmmbuild  -o /dev/null HMM SEED	711	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.48	0.70	-5.84	15	113	2009-01-15 18:05:59	2008-08-29 11:05:14	3	5	100	0	90	116	0	597.80	28	77.07	CHANGED	P+IPPRP.s+Rh-RSsSP....ssaAPSPLN-.s.............ptp.s.p...sPpRPsSV.slPSlGEEGtEYpslsssshoss........soPsp..oRsVusDL+LHAP+PSlPsuoAKu+lpAVTRTDSppAsAsGhG.tsuuPttcshtcpsocSLpspsosopssSusspstp..Sht..s-EHGI.PEIGQpVPM.hsNAGDVQAPSPuPhp.............pt.tptHtRppSuRt..uLPPGSYGLHGHGl.ss-+FEKAaYEKHP--hs+E-pupatsslGpsRs.DaAlSuDDLN+IV+toAspGsGLus..thsuTPpEplGahAs-EhopRhuoPsPcSsp.................hcsPl+.p..s.t...............................hIHlDpPh+p...............tp..tt.sttt.s.......-pPILAuD.....EVphcsuhpp...PAVSPohc+c............p...ptp..SsscSRssS+ssshptshst.hc...........psPLEDVcEYEPLFPED-pcsh.ctshspss..........................+.c.+sp.hp++FPSpDlWEDoPsShphp.usVSTP-..................tpcshEsPcQpssRcoptsshcs.....................pps.....psc.....ptpcstsRsph.pQRFPS...RDlWEDuPESppLsTTlpss...................................--hpspSPtss.sKPslPu..RPp...+.............s.csttps.s.spcc+pPPslPsRP..................KPQIPARPuKstsppsu-.......pstp.s............sKsKPsVPuRPtGSKIAA..L+AGFluDLNuRLpLG........PQuPp+.....ppppct...............ppptsssEKuPLSDA......RKGRARGPtRR+PAst...............sst+hsshsplshspsassWpls	.............................................................................................P.lPsRP..pt..ps..s............SPhs.......................................+..s...h..hs.p..-ht.....................s.p...t.htp-..h.AspPslPstpsptph.sVTps-sp.utthh.....s.s...t.........................................t..t...................tpcpuI..plu.pVPh...phGsVQAPoPus.t.................t.p.p..St......Psuohuh+sHt......psth-pshhpKHPc.hth.pts...........c..phuhSspcLNclV+pst......s...t..usPp-pluh.t.-chspRhsss.sts................................................................lHlc...p.........................................................t.............................ptPlLAsD.....Elt.pst..t...PAlsPthtpp...........................u.s...ps...+.ps+s....t.....s....t........................ttslcclcEhEPLF..---tp....p...tttp.................................................................p....p.........pcFPS..pDlWE...D.sPsuhphp..spVoosc...........................t..psPt....pt.tppppt.t.p...................................t.......t.t.p...tt.c..t........pp+..FPS...+DlWEDs.P-Stphtsplp.s.......................................pp..t.pss..t....pp.P..tlPt...RPp..................................................s.p.s.....t..s...ttp+tsPslPc+P..................KPp..lPsR.sp.tpppstp.........p....s...................s+sKPslPsR.P....s..GuK.....IAA..lpAGFhscLNs+LpLG............Ptssp...........tpp.t....................................pttp.tc.+..sPLu.DA......RKGRARGPtRRtP..sh...........s...ssstc..hstssp.hph..shshWpl............................	0	15	45	72
+11322	PF11490	DNA_pol3_a_NII	DNA_pol3_alph_N;	DNA polymerase III polC-type N-terminus II	Finn R, Coggill P	anon	Pfam-B_853 (release 23.0)	Domain	This is the second N-terminal domain, NII domain, of the DNA polymerase III polC subunit A that is found only in Firmicutes. DNA polymerase polC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria [1].  Purine asymmetry is a characteristic of organisms with a heterodimeric DNA polymerase III alpha-subunit constituted by polC which probably plays a direct role in the maintenance of strand-biased gene distribution; since, among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased [2]. It has been predicted that the N-terminus of polC folds into two globular domains, NI and NII. A predicted hydrophobic surface patch suggests this domain may be involved in protein binding [3]. This domain is associated with DNA_pol3_alpha Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF14480.	22.10	22.10	22.10	22.10	21.90	22.00	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.30	0.71	-4.48	63	1162	2012-10-02 15:09:17	2008-08-29 11:09:41	3	24	1157	0	139	793	71	115.20	23	8.07	CHANGED	sYappllpphsp.tssshpshLpppphph.cssclh.lhstschhtshl+ppthshlhpphhphGFs....hphpsplpp.p.spp.h....ppappp+tpc-p...phspp...shpphpppppptpppppp	............pYappslppsst..to..s..hh+uh.hppppsph..ps.spLh.l.sssslppsahccpt.hsslhcpapphGFs.....phphphchsc.t.s....ppph.............psactpppppsp...ptspp...........Ahcthcphcttts..tp.p........................................	0	44	85	113
+11323	PF11491	DUF3213		Protein of unknown function (DUF3213)   	Pollington J	anon	pdb_2f40	Family	The backbone structure of this family of proteins has been determined however the function remains unknown. The protein has an alpha and beta structure with a ferredoxin-like fold [1].	20.30	20.30	21.30	86.90	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.01	0.72	-4.11	2	12	2009-01-15 18:05:59	2008-08-29 11:11:46	3	1	12	1	9	16	0	87.70	47	91.88	CHANGED	h.lKF.ssls.EcApIhQYELppc-chaRlFlNsYA+su.VlhD-phhshEEL...hEcLKsEVltEKplTlQELIEtShSWNNVh.S+u	.l.pl+F.GpIs.EEAphhQYELppctuVaRlFlNGYA+sGhVlFD-pplscEclLchLcchcPEVlpE+clTlpELIEpShSWpNlh....t..	0	1	1	6
+11324	PF11492	Dicistro_VP4		Cricket paralysis virus, VP4	Tate JG, Finn RD	anon	pdb_1b35	Family	This is a family of minor capsid proteins, known as VP4, from the dicistroviridae. The dicistroviridae is a group of small, RNA-containing viruses that are closely structurally related to the picornaviridae. VP4 is a short, extended polypeptide chain found within the viral capsid, at the interface between the external protein shell and packaged RNA genome[1].	22.60	22.60	23.40	40.80	22.30	20.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.83	0.72	-3.96	11	50	2009-01-15 18:05:59	2008-08-29 11:12:18	3	7	19	1	0	54	0	57.20	45	6.17	CHANGED	uusEhpps....GsIScsAosVuplAssls..plPllGshA+s....spWlustVuslAplFGa	......soEssp.....GsISclAouVssVANsl-..pIPllGpIAKP....lpWVushVusVAulFGa	0	0	0	0
+11325	PF11493	TSP9		Thylakoid soluble phosphoprotein TSP9	Pollington J	anon	pdb_2fft	Family	The plant-specific protein, TSP9 is phosphorylated and released in response to changing light conditions from the photosynthetic membrane. The protein resembles the characteristics of transcription/translation regulatory factors. The structure of the protein is predicted to consist of a random coil [1].	25.00	25.00	43.60	43.40	21.10	20.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.78	0.72	-3.43	5	29	2009-09-11 09:35:24	2008-08-29 11:52:16	3	1	16	1	15	31	0	77.20	43	68.38	CHANGED	AT+G.GoAss+EEKuhhDalhGhlhKcDQhhETDPlLpKVDtKuPSGSTsu+KAsu+uPAsSA.....Ac-EGGsGGFsLGuLFAK	..........stt.tuusucEEKGlhDaIhGtlhKc-Q.h.lETDPlLpKV-pKs.u.Gs.....osup....Kus..ssustpts......tcccGGsGG.....hG...GLFuK...	0	1	7	11
+11326	PF11494	Ta0938		Ta0938	Pollington J	anon	pdb_2fqh	Family	Ta0938 is a protein of unknown function however the structure has been determined. The protein has a novel fold and a putative Zn-binding motif. The structure has two different parts, one region contains a beta sheet flanked by two alpha helices and the other contains a bundle of loops which contain all cysteines in the protein [1].	22.80	22.80	22.80	23.00	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.33	0.72	-3.92	4	21	2009-01-15 18:05:59	2008-08-29 13:09:29	3	1	20	1	8	17	1	99.50	61	93.18	CHANGED	M...KIlVNG+EAGTKEKGCALCGuTWGDYYE-lDGE+LFFCCDICAhEFlNMlsEVKK+TuWs+lDELlINGNY.pGRsC.uKsGs+ch+FYVKFs--AsIcTF+.hs	.....MKIlVNG+EAGTKEsGCALCGGTWG.DYYEEIDGEKLFFCCDlCA.LEFVNMlNEVKKRTsWSRIDELlI..NGNYYTGRTCsAKsGs+EYKFYVKFNDDAsIETFKEls..................	0	3	4	7
+11327	PF11495	Regulator_TrmB		Archaeal transcriptional regulator TrmB	Pollington J	anon	pdb_2f5t	Family	TrmB is an alpha-glucoside sensing transcriptional regulator. The protein is the transcriptional repressor for gene cluster encoding trehalose/maltose ABC transporter in T.litoralis and P.furiosus [1]. TrmB has lost its DNA binding domain but retained its sugar recognition site. A nonreducing glucosyl residue is shared by all substrates bound to TrmB which suggests that its a common recognition motif [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.31	0.70	-5.39	30	611	2012-10-02 13:01:53	2008-08-29 13:10:22	3	5	362	2	163	568	67	147.60	19	52.42	CHANGED	tl.hl+uhpsllpphp-lIpsAcpElhluls.chLcplpctLhsuhccGVpVhLllhs.....sss.s.hchhsssstlRhpcsss.shl....lluDtppulhsspp........pscscpYulhhpcpsLhhhlsthFhsshWtpuphlh...spshshPhpasshRhulpslpphhppuhslpuplpGhshp.oscphslpGcl..ss.............hsthst.hsshhlcoscu.plsVGGhsAhlEDlEupplplptt	....................................h.lhsl+uppsllpphpplIppAcpcl.hl....u.....s....h....p....-.....l.....p.p.....l....c...s....t.....LppstccG..Vplh.hl..hhs..............hpssh.p..h.c...h....h...t.h....s.p..............s..c..ht..tt..t..c...hh.l..................lssDs.cchlhu.s......................ppp..u..hhs...p.....hhhhh.............................................................................................................................................................................thhh.....................................................................................	0	39	99	140
+11328	PF11496	HDA2-3		Class II histone deacetylase complex subunits 2 and 3	Wood V, Coggill P	anon	Chahwan C	Family	This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus [1].	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-12.01	0.70	-5.60	26	146	2012-10-05 12:31:09	2008-08-29 13:22:22	3	6	101	6	102	1604	22	269.30	22	34.08	CHANGED	sssu-ahlPssMsphQK-Lh-pllslatpsIlca.h...cspspppsh.................................pphchhhpphphlusHP..L.Ll-HaMP+ph........hht-.stchttoSuKFtlLscLlshl..............pppp......................hpllllscssKph-LlEulLhG.....+tlphpRhsuphlhscs+chs............................................................................................t.thusslaLhsocslhpp..sss..tp.phshlIuhDssl-spsPslpplRppptp................................................t............sPllRLlshsSsEHhtLpasp.....tt.p.h.th..t.......................LRchlGslssD...shslhpp..lchlssal	.........................................................................................................................t..stcahlPhshsthpK-hh-pll.s.h.ctps.lhca..h...........csp.s..pps.h...................................................................................................pph..ph..h..hpplp.lssHP....L...l........l.....-....H.h..h..Ppph......................................................h.t..c..........s.....t......p....h..t...t..s..SuKFphLppLl.shl.........................pphp......................hcllllscs.s+phDLlEuhl..lG...............pphp..hpRhsu..p..p..h.hsp.ppths............................................................................................................................................................................thshtlp.L.h.ss.p......thhp..........p.s.....phsh.lIshDs.s..h.......-spt..ssl...phlcppt.pp...................................................................................t.hPll+Lls.soh-HhtLhhsph.........pp.p..l..phhtt.......................hps.hGpl.ss....h....p..................................................................................................................................................	0	21	53	89
+11329	PF11497	NADH_Oxid_Nqo15		NADH-quinone oxidoreductase chain 15	Pollington J	anon	pdb_2fug	Family	This protein, Nqo15, is a part of respiratory complex 1 which is a complex that plays a central role in cellular energy production in both bacteria and mitochondria. Nqo15 has a similar fold to Frataxin, the mitochondrial iron chaperone. This protein may have a role in iron-sulphur cluster regeneration in the complex. This domain represents more than half the molecular mass of the entire complex [1].	25.00	25.00	26.50	114.90	19.00	17.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.51	0.71	-4.40	3	17	2009-01-15 18:05:59	2008-08-29 13:32:55	3	1	17	15	11	16	2	127.70	62	96.40	CHANGED	MAsAs-ccLYcQWVELLGWLc-EApoRGLuFEKVADFPDYIYRMERPYDLPTTVMSVuLSsG.GQPLLLAAVSPRHVDLKGISLRLMGGSKHWHLHA...Gu+GLLEGKRPFTRERLuVLLDGAhRGlAsV	......Mutup-ctLYcAWVELLuWM+EYApt+.GVpFEKEADFPDFIYRMERPYDLPTTlMoASLSDuhGEPFLLAsVSPRHAcLK+IuLRL..s+tHhHLHA..EsG+G.L.l.sGKlPLTKERhasLADRARculuh.....	0	3	7	11
+11330	PF11498	Activator_LAG-3		Transcriptional activator LAG-3	Pollington J	anon	pdb_2fo1	Family	The C.elegans Notch pathway, involved in the control of growth, differentiation and patterning in animal development, relies on either of the receptors GLP-1 or LIN-12 [1]. Both these receptors promote signalling by the recruitment of LAG-3 to target promoters, where it then acts as a transcriptional activator. LAG-3 works as a ternary complex together with the DNA binding protein, LAG-1 [1].	23.30	23.30	23.70	24.90	22.50	23.20	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.93	0.70	-5.74	2	17	2009-01-15 18:05:59	2008-08-29 13:48:28	3	5	8	1	16	20	0	259.40	31	60.52	CHANGED	MKPSTSK...ospSPPPEEPsusaVNspLPsP-DEPhlu-hssappGpE.tR.RSp.AhtpapKsR.E.IusQRAVTApLapRaTEDEERKRhEpQKNKEAMNASsu..ouSRNG..pl-NRKRRND..Vus.ouEEEW+RA.QQQHWMGQttP.h.paQMQQQYH.QQQ....httQHHphh................u.+SVPTP.uShHpPSPutMpssC...................PhsDENsLsVPpGEWFDKLAlhVAEpYsssTILGPDTYDsaLsELDh.ps.u.ThpoP.Ehs.....poAs.P..NPQp.tQhtQQQNKMRhhQQQp.....hEQQRpQQhMpQpQQQ....HppQQMLL.QQQQ.pQhQQppQMN.GGQF.TQApQpAsYhQpMQ+M...pQ.ppQQQQAQpHQQA.QQHQQ.tQpt.MGYulPNGY.tp.phasP.YG.HHMPp.TsFANIN	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..ppQ...QpphhhhQQQp............p.hppQR.pQQh.Qtp...Q....p.pp.QQh....p.......ppt..........pt...psshhp.....h..pph...p...................................................................................................	0	4	5	16
+11332	PF11500	Cut12		Spindle pole body formation-associated protein	Wood V, Coggill P	anon	Chahwan C	Domain	This is the central coiled-coil region of cut12 also found in other fungi, barring S. cerevisiae. The full protein has two predicted coiled-coil regions, and one consensus phosphorylation site for p34cdc2 and two for MAP kinase. During fission yeast mitosis, the duplicated spindle pole bodies (SPBs) nucleate microtubule arrays that interdigitate to form the mitotic spindle. Cut12 is localised to the SPB throughout the cell cycle, predominantly around the inner face of the interphase SPB, adjacent to the nucleus [1]. Cut12 associates with Fin1 and is important in this context for the activity of Plo1 [2].	21.50	21.50	22.80	22.80	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-10.99	0.71	-4.52	12	71	2009-09-11 11:20:04	2008-08-29 14:19:16	3	3	70	0	60	71	1	150.90	34	21.61	CHANGED	-ups+PRo+LTpALhDSR......cp.....st.t.....stpct...css.sscss..........t.pshp..tc-sD.TINLs-PRSpSGKYWKuEF...DsY+s+optEl+KLIp...............Y+phAKsYA+cKDpEApcLucKLKEEE...tKVupMEcclTpLsSsMsscsspss.....+EpLhp-	..............................................t..p.p.Ro+LopuL.c.uRp.............t..p........sp.................shppp.ppstpscp.................................pspspc..ps-sDsTlsLs-P+SQSG.KYWKuEF.........-sY+scsctEhcKLlp...............Y+plAKSYA+cKDsEAhcLs...cK.LKcEp...tKVtpMEc+lsc.hAuphssptsp...ts.....p..............................	0	10	27	46
+11333	PF11501	Nsp1		Non structural protein Nsp1	Pollington J	anon	pdb_2gdt	Family	Nsp1 is the N-terminal cleavage product from the viral replicase that mediates RNA replication and processing [1]. The specific function of the protein is unknown however the structure has been determined. The protein has a novel alpha/beta fold formed by a 6 stranded beta barrel with an alpha helix covering one end of the barrel and another helix alongside the barrel [1]. Nsp1 could be involved in the degradation of mRNA.	25.00	25.00	41.00	38.30	19.90	18.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.49	0.71	-4.25	3	172	2009-01-15 18:05:59	2008-08-29 14:20:12	3	4	67	2	0	150	0	115.00	98	1.95	CHANGED	HVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTsHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNG	..................HVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGVLPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRNVLLRKNG	0	0	0	0
+11334	PF11502	BCL9		B-cell lymphoma 9 protein	Pollington J	anon	pdb_2gl7	Family	The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes [1].	25.00	25.00	28.60	38.20	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-7.95	0.72	-4.43	7	124	2009-01-15 18:05:59	2008-08-29 14:29:02	3	1	64	6	72	108	0	39.90	55	3.04	CHANGED	GLSpEQLEHRERSLQTLRDIQRMLFP-.-+shuhts.st.p	..GLSpEQLEHRERSLQTLRDIpRhLFP-.Ep-.shtt..................	0	9	15	39
+11335	PF11503	DUF3215		Protein of unknown function (DUF3215)	Pollington J	anon	pdb_2grg	Family	This family of proteins with unknown function appears to be restricted to Saccharomycetaceae.	25.00	25.00	26.30	46.00	22.00	19.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.32	0.72	-4.35	4	29	2009-01-15 18:05:59	2008-08-29 14:51:24	3	1	19	1	17	22	0	80.50	36	91.50	CHANGED	hslsEhlssslGolsFDENtNll-ooGlG....ppRlpDIscLSpscLDppGaulhpDssl.spla+css+TlsVYTs..............up	.........tEhlPcslGTLsFD-NtNll-ooGlG.....cs+lpDIhclSpscLsppGa.ulhpD...splllplaKc..ss+TlslYTs...pp..............	0	2	9	17
+11336	PF11504	Colicin_Ia		Colicin Ia	Pollington J	anon	pdb_2hdi	Family	Colicins are toxic molecules secreted to kill other bacteria in times of stress. Colicin Ia kills susceptible E.coli cells by binding to the colicin I receptor leading to the formation of a voltage-dependant ion channel. The protein can be divided into three domains, a translocation domain, a receptor binding domain and a channel forming domain [1].	25.00	25.00	25.90	53.30	24.00	16.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.35	0.72	-4.08	3	56	2009-01-15 18:05:59	2008-08-29 15:50:56	3	2	40	2	0	53	0	70.40	98	12.45	CHANGED	KNTPDGKTIVSPEKFPGRSSTNDSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLSHSGLDYKRNILNDRNP	.....KNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNP	0	0	0	0
+11337	PF11505	DUF3216		Protein of unknown function (DUF3216)	Pollington J	anon	pdb_2hjm	Family	This family of archaeal proteins with unknown function appears to be restricted ton Thermococcaceae.	25.00	25.00	72.60	72.20	24.10	23.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.17	0.72	-4.19	2	14	2009-01-15 18:05:59	2008-09-01 09:09:30	3	2	13	4	11	16	0	95.10	49	60.44	CHANGED	MDhsEKVKtLs.cLtE-pLtcAI-RFlTLscGIEKTRGEtFAKAuIYGFLEGILTTLKhKapsEcIppLLs.lKpARE.pEAhLRKspPPlh.ppsL	........lE-VKuLscELGE-sLlpsIDuFlsLNcGLEsK+GE-FlcVuILGFLEGILTTLKhKa.p--+lscLL-cV+ppRtEL-thFRKs+sPlh-.........	0	1	1	6
+11338	PF11506	DUF3217		Protein of unknown function (DUF3217)	Pollington J	anon	pdb_2hql	Family	This family of proteins with unknown function appears to be restricted to Mycoplasma. Some members in this family of proteins are annotated as MG376 however this cannot be confirmed.	23.60	23.60	23.80	108.70	21.90	23.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.19	0.72	-4.33	2	7	2009-01-15 18:05:59	2008-09-01 09:20:58	3	1	7	6	3	5	0	99.70	69	100.00	CHANGED	MLNpVFLEGEIESopWShKKTGFLVTIKQhRhFGER.FTDaaVhYANGQLAaELEtaTpKaKTISIEGILRTYLE++StIWKTTIElVKIhpPpsclhIDYpE.	MLNpVhLEG.I-S.pWShpKTGFhVTIpQhRhFGpphFTDYYVIYANsQLuhELEKashcachluIcG.LpTY.-+KSclWKTpI.h.KIh................	0	2	2	2
+11339	PF11507	Transcript_VP30		Ebola virus-specific transcription factor VP30	Pollington J	anon	pdb_2i8b	Family	VP30 is a nucleocapsid-associated Ebola virus-specific transcription factor [1]. It acts by stabilising nascent mRNA in Ebola virus replication. The C terminal domain of VP30 folds into a dimeric helical assembly. VP30 assembles into hexamers in solution by an N-terminal oligomerisation domain which activates the transcription function of the protein. The oligomerisation is mediated by hydrophobic amino acids at 94-112 [1].	20.00	20.00	22.50	22.30	19.30	17.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.62	0.71	-4.32	3	31	2009-01-15 18:05:59	2008-09-01 09:42:50	3	1	20	4	1	29	0	130.00	60	46.56	CHANGED	LTLclLlcIAEaWAsp-IsclDDoKLRALLTLoAVLlRKFSKSQLupLCEoHLRHENLGQDQA-SVLEVYQRLHSDKGGsFEAALWQQWDRQSLoMFISAFLaVALQIPCESSoVVlSGLcpLhPPQsNus	...LTLcsLs+IhpYhpRp-IsclD-opL...RAhLoLosshlRKh..s+S.lsshsEhHlpHENLsQDQssslhpsYptlH.DKGGpFEAALWQtWD+pSlohFlpAhLaVhpsIPCESShsV.uuhcphl.Ppspu.......	0	1	1	1
+11340	PF11508	DUF3218		Protein of unknown function (DUF3218)	Pollington J	anon	pdb_2igs	Family	This family of proteins with unknown function appears to be restricted to Pseudomonas.	25.00	25.00	30.30	134.00	21.50	17.40	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.31	0.70	-4.83	2	9	2009-01-15 18:05:59	2008-09-01 09:51:37	3	1	6	8	1	8	0	187.90	63	96.74	CHANGED	pINIYQNPGQSluslYKGhApQCsPG.sFPEsQhlEAWDIPLhLHPEFlPsGDlSKhDppYuTlLAtE.ApslhlthpMsp-Kt+sCs.ElhsLloShupNLspIKuRaGusYLshhKtSPNhYPTsVGhph.uuGu.sQ-SGl.VSYGssLtpLT.uphQAMsLPtslKtLls.GlGl+LstPpa.ssaNsItoGlRYTTuVslhLAYaAsl	..pINIYQNPGQSluslYKGhApQCsPG.sFPEAQhlEAWDIPLhLHPEFlPsGDlSKhDppYuTlLAtE.AphlhlthpMsp-Kt+sCs.ElhsLloShupNLspIKuRaGuuYLshhKtSPNhYPTsVGhph.uuGu.sQ-SGl.VSYGsNLtpLT.uphQAMsLPtslKtLls.GlGl+LstPpa.ssaNsItoGlRYTTuVslhLAYaAsl.......	0	1	1	1
+11342	PF11510	FA_FANCE		Fanconi Anaemia group E protein FANCE	Pollington J	anon	pdb_2ilr	Family	Fanconi Anaemia (FA) is a cancer predisposition disorder. In response to DNA damage, the FA core complex monoubiquitinates the downatream FANCD2 protein. The protein FANCE has an important role in DNA repair as it is the FANCD2-binding protein in the FA core complex so it represents the link between the FA core complex and FANCD2 [1]. The sequence shown is the C terminal domain of the protein which consists predominantly of helices and does not contain any beta-strand. The fold of the polypeptide is a continuous right-handed solenoidal pattern from the N terminal to the C terminal end [1].	22.20	22.20	24.00	23.50	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.86	0.70	-5.25	2	95	2009-09-11 15:02:58	2008-09-01 11:06:15	3	2	65	1	56	91	0	198.80	32	49.62	CHANGED	u....LupShpLPcthpstLPhlppLLcs.pE....h-DussstLplLHECsPsph-lLCu.LpLsplS-.sL.phCohLLtLuPDLShSsAosLhppLhLt+ILSLspsASRhLsTAlTShCu+YshPsCpALl-PlLQtsthGsAQs-LLCpLV.h-sLEPctplLhhtphLthsWcEtsh.VlpuLL-pplEho.EcFslhhE+LCppu.thopSMtaAKhhLoVhTKYQuNls.sp+hsLu.sLp.NpTFL+KSLpAALK+lu	............................................................................................................................ht.lst.Lph.phs-.slhplCs......lhs..L.o...sshSh....ss.....u.ss.lh.psLhLs+lluL..sp.sASRh..LhsAlsshC.t..+ashssspullhP.l.L.p....ts.t.......h.Gss.Qs-LLspll...t-..sLc...............sch.....p...h..hh...l....t...p..h.....L................p........h..s...........W..pEth.h.VlpslLppp.....hs....p.ht.hhp.l.....t.....tt..u.t....hspShtauphhhshhsphttplt..p.....l..hlt.stThhp+sh.shl....t..........................	0	15	22	37
+11343	PF11511	RhodobacterPufX		Intrinsic membrane protein PufX	Pollington J	anon	pdb_2ita	Family	PufX organises RC-LH1, the photosynthesis reaction centre-light harvesting complex 1 core complex of Rhodobacter sphaeroides [1]. It also facilitates the exchange of quinol for quinone between the reaction centre and cytochrome bc(1) complexes. In organic solvent, PufX contains two hydrophobic helices which are flanked by unstructured regions and connected by a helical bend [1].	25.00	25.00	30.80	30.70	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.92	0.72	-4.58	5	18	2009-01-15 18:05:59	2008-09-01 12:54:39	3	1	18	3	3	14	33	66.20	38	84.78	CHANGED	MscaNDhLss..NsKoRLRADlshLMLKGAGYAAVFVlulWFlIuuhtlIG+hLPEQSRpTPDPsppuA	..........ho..sDaLss..ssKspLRlWlshQMhKGAGaAussFhuslhllsshtslGphLP.ppppAPuPs.h.....	0	1	2	2
+11344	PF11512	Atu4866		Agrobacterium tumefaciens protein Atu4866	Pollington J	anon	pdb_2jmb	Family	Atu4866 is a protein with unknown function from Agrobacterium tumefaciens however the structure has been determined. Atu4866 adopts a streptavidin-like fold and has a beta-barrel/sandwich which is formed by eight antiparallel beta-strands [1]. Atu4866 has a potential ligand-binding site where is has a stretch of conserved residues on the surface [1].	25.00	25.00	25.70	25.30	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.57	0.72	-4.24	14	114	2009-01-15 18:05:59	2008-09-01 13:19:10	3	2	95	1	47	122	1	77.40	61	65.27	CHANGED	tpp+sYlGMWVTuDGaIRHELLPsGRYDEARGsRcSAYpGRYclTGsHI-YhDDTGFTADG-Fh.ssVLaHuGMVLaRc	..................tHPYVGMWVTsDGpIRpELLPsGRYDEARGsRcSAYpGRYpVsGsHI-YhDDTGFTADG-Fh.-slLaHuGMVhYRp.....	0	11	26	33
+11345	PF11513	TA0956		Thermoplasma acidophilum protein TA0956	Pollington J	anon	pdb_2jmk	Family	TA0956 is a protein from Thermoplasma acidophilum which currently has no known function however the structure has been determined. The protein has a two-layered alpha/beta-sandwich topology and is a putative Elongation factor 1-alpha binding motif [1].	25.00	25.00	181.50	181.30	22.20	18.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.27	0.72	-4.01	3	3	2009-01-15 18:05:59	2008-09-01 13:27:54	3	1	3	2	3	7	4	110.30	51	97.07	CHANGED	MsLCAMYNISMcspHPTTICVVMDKFLDSFuELlDVl--sDpDE.LMDFISRYARTDEIMPEDKTVGFVVINuDKKlMSVSFSDIDENM...KcsI+EIlKKYKDpGYKVEsDh	MsLCAMYNISMcspHPTTICVVMDKFLDSFuELlDVl--sDpDE.LMDFISRYARTDEIMPEDKTVGFVVINuDKKlMSVSFSDIDENM...KcsI+EIlKKYKDpGYKVEsDh	0	1	2	2
+11346	PF11514	DUF3219		Protein of unknown function (DUF3219)	Pollington J	anon	pdb_2jn9	Family	This family of proteins with unknown function appears to be restricted to Bacillaceae. Some members in this family of proteins are annotated as YkvR however this cannot be confirmed.	25.00	25.00	82.10	82.00	16.80	16.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.37	0.72	-4.10	2	29	2009-01-15 18:05:59	2008-09-01 13:38:47	3	1	29	1	7	31	0	92.60	55	97.71	CHANGED	KplhLNsspl-hhsYpEEo...cscptI..uFshpVopppYHDIssLLY-hhFsVpVPEcsLtFRG.hspY.TSLTNLYE.sAVuEFalElpEhDtptD	..................lhLNsVplchhsYpEEs.......cstRpI..uFsLcVTSETYHDIAVLLYEKTFcVcVPE+sLsFRGpITNYSTSlTNLYccspVu-FalElTEl.........	1	1	5	5
+11347	PF11515	Cul7		Mouse development and cellular proliferation protein Cullin-7	Pollington J	anon	pdb_2jng	Family	The Cullin Ring Ligase family member, Cul7, is required for normal mouse development and cellular proliferation. Cul7 has a CPH domain which is a p53 interaction domain. The CPH domain interaction surface of P53 is present in the tetramerisation domain [1].	25.00	25.00	25.10	28.80	20.10	18.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.81	0.72	-4.08	8	206	2009-01-15 18:05:59	2008-09-01 13:50:29	3	43	71	2	103	188	0	76.00	52	2.97	CHANGED	RcDFpSsDsYAhYVR-slpsGMhVRCCc-YEElppGDhGpVh+l-s-GlpDLNVQVsWps+GpTYWV+ahHVEllGsss	.........Ru-FtSsssYAhYVR-slpsGMpVRhhc-YE.Els.tGD.Gc.h+.sssGl.s..VQV.WpspGpTYWV+ahhlEllGh.s...............	0	19	23	51
+11348	PF11516	DUF3220		Protein of unknown function (DUF3120)	Pollington J	anon	pdb_2jpf	Family	This family of proteins with unknown function appears to be restricted to Bordetella.	25.00	25.00	240.50	240.50	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.34	0.72	-4.06	2	4	2009-01-15 18:05:59	2008-09-01 14:06:47	3	1	4	1	1	4	0	106.00	98	16.14	CHANGED	KQQLpEpAPSHANLDVKWLDGLRAGSMALQGDVKVWMQNLEDLHTRRPDEFsARLQQSTDALYSHLEAQWAKQHGTPPTASDVsGMPQWQEYTAMLRERFAGLDTI	KQQLHEQAPSHANLDVKWLDGLRAGSMALQGDVKVWMQNLEDLHTRRPDEFAARLQQSTDALYSHLEAQWAKQHGTPPTASDVAGMPQWQEYTAMLRERFAGLDTI	0	1	1	1
+11349	PF11517	Nab2		Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)	Pollington J	anon	pdb_2jps	Family	Nab2 is a yeast heterogeneous nuclear ribonucleoprotein that modulates poly(A) tail length and mRNA. This is the N terminal domain of the protein which mediates interactions with the C-terminal globular domain, Myosin-like protein 1 and the mRNA export factor, Gfd1 [1].The N-terminal domain of Nab2 shows a structure of a helical fold. The N terminal domain of Nab2 is thought to mediate protein protein interactions that facilitate the nuclear export of mRNA [1]. An essential hydrophobic Phe73 patch on the N terminal domain is thought to be a important component of the interface between Nab2 and Mlp1 [1].	25.00	25.00	32.40	30.40	23.10	22.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.44	0.72	-3.96	4	26	2009-01-15 18:05:59	2008-09-01 15:41:18	3	4	26	4	17	26	0	101.20	57	19.60	CHANGED	MS..p-pIspsLKslVAEKLpsl.NFsEDVpYVAEYIVLLhSNGGoh-SlVQELsoLFDoVSppsLssVVQTuFhAL-hLppG-slpslhuKlp...hhuupssupusos	.......MS..pEQhoENLKVIVAEKLssl.NFNEDlcYVAEYIVLLIsNGGTlESVVpELuoLF.DoVSp-sLssVVQTAFFALEALQQGEosEsIVuKIR...hM.supuhupt...s..............................................	0	2	8	14
+11350	PF11518	DUF3221		Protein of unknown function (DUF3221)	Pollington J	anon	pdb_2jqo	Family	This family of proteins with unknown function appears to be restricted to Bacillus. Some members in this family of proteins are annotated as YobA however this cannot be confirmed. YobA is a protein with unknown function.	20.80	20.80	21.00	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.45	0.72	-4.39	9	132	2009-01-15 18:05:59	2008-09-01 15:47:07	3	2	109	1	15	95	1	105.10	40	84.54	CHANGED	lhL.lhhhlhotsssptsE...spphohEGYlIl+.NspshhlsDcshpsK.-hpphhEpplhpcasusIVL....thpshsshcpLpsGpKIKVWasplhES.Pu+hhlpKaEll	..............................hh.lhLhlhu..s.sssppsE..........sccsshEGYlIl+.N-.s...s..a...hlsDcshpsK.ELppY.hEp...php..p-aPucIlL.....hc-c..-.u..acpLKsGDKIKVW..S.p...h.hESYPu+hhVpKaEl..........	0	2	9	11
+11351	PF11519	DUF3222		Protein of unknown function (DUF3222)	Pollington J	anon	pdb_2js3	Family	This family of proteins with unknown function appears to be restricted to Rhodopseudomonas.	25.00	25.00	141.40	141.30	19.50	17.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.56	0.72	-4.02	3	7	2009-01-15 18:05:59	2008-09-01 15:50:14	3	1	7	2	6	7	0	74.70	74	100.00	CHANGED	MT-FAAEDVRKIAAALVKTAIETVSEEDGGARNQCKLCNASVPWLQTGDEIpHpPDCAVAIAQRIL.AKs+LHSV	MTDhAAEDVRKIAsALlKTAIEIVSEEDGGAHNQCKLCsASVPWLQTGDEIpHAPDCPVVIApplLuu+P+LHuV	0	0	1	2
+11352	PF11520	Cren7		Chromatin protein Cren7	Pollinton J	anon	pdb_2jtm	Family	Cren7 is a chromatin protein found in Crenarchaeota and has a higher affinity for double-stranded DNA than for single-stranded DNA. The protein contains negative DNA supercoils and is associated with genomic DNA in vivo.Cren7 interacts with duplex DNA through a beta-sheet and a long flexible loop. The function has not been completely determined but it is thought that the protein may have a role similar to that of archaeal proteins in Euryarchaea [1].	39.00	39.00	60.50	60.20	38.80	37.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-8.87	0.72	-4.33	7	51	2009-01-15 18:05:59	2008-09-01 16:18:15	3	1	43	5	34	42	0	58.70	53	95.26	CHANGED	M....sscc..shcs+ss.sGKEhcLhPhKsW.LsP+GRKGVhlGLF+sPp.GKYFRt+Vs-t.P	............tcc..sl+l+ss.sGKEh-LhPpKVWsLsPKGRKGVKIGLFKsP-oGKaFR++lP-sYP..	0	10	19	24
+11353	PF11521	TFIIE-A_C-term		C-terminal general transcription factor TFIIE alpha	Pollington J	anon	pdb_2jtx	Family	TFIIE is compiled of two subunits, alpha and beta. This family of proteins are the C terminal domain of the alpha subunit of the protein which is the largest subunit and contains several functional domains which are important for basal transcription and cell growth. The C terminal end of the protein binds directly to the amino-terminal PH domain of p62/Tfb1 (of IIH) which is involved in the recruitment of the general transcription factor IIH to the transcription preinitiation complex. P53 competes for the same binding site as TFIIE alpha which shows their structural similarity. Like p53, TFIIE alpha 336-439 can activate transcription in vivo [1].	21.10	21.10	21.20	21.40	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.99	0.72	-4.04	8	111	2009-01-15 18:05:59	2008-09-01 16:44:00	3	5	89	3	80	101	0	84.30	38	19.99	CHANGED	SsSDTSESDcD.ssscsPstt..........spch--p--DD-.E-ssD-PsVhVuGRPasYcEVSQpPcLVuQMTPQEKEsYIphGQchFpclY-	......................................spS-oS-s-c-.s....sc.ss.ss...............phc.tc-p-----hE-s...sD..-P..sVhVAG+Pashs-V.o...P-LV.A.QMTPpEKEsYIp.hsQchFpcha-......	0	28	35	58
+11354	PF11522	Pik1		Yeast phosphatidylinositol-4-OH kinase Pik1	Pollington J	anon	pdb_2ju0	Family	Pik1 is a regulator of membrane traffic and participates in the mating-pheromone signal-transduction cascade. The protein is localised to the nucleus and cytoplasm in the Golgi. Pik1 is thought to have an actin-independent role in membrane transport [1].	21.40	21.40	21.40	24.60	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.62	0.72	-4.22	20	95	2009-09-10 18:11:33	2008-09-01 16:58:07	3	4	83	1	64	94	0	50.50	41	5.27	CHANGED	SauFQlsRRllN+lQpllFsss...................pps+ps+h+ENltPALVLsuhVhoSlA	......ShuFQssRRlhN+lQpIlFsss....................sts+pp+h+ENlhPuhVLuShlhuSlA.................	0	16	39	60
+11355	PF11523	DUF3223		Protein of unknown function (DUF3223)	Pollington J	anon	pdb_2k0m	Family	This family of proteins has no known function.	21.00	21.00	22.60	21.90	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.61	0.72	-3.69	30	196	2009-01-15 18:05:59	2008-09-02 09:24:51	3	16	68	1	129	193	9	74.50	34	13.45	CHANGED	h+thL+..+YssGcpls..sp-tpsllptlLpaHP.....cs-pKlGsG.l.cthpVtpasthp.t....S+CFalVRs..DGop.....-DFSYpKCl	...........h.ptlL+..catssppls..tp-pphllcplLpaHP................csccKIGsG....l.ctlpVshHPtap..t.....SRCFallRp..DGot......pDFSYpKCl..............	0	38	90	114
+11356	PF11524	SeleniumBinding		Selenium binding protein	Pollington J	anon	pdb_2jz7	Family	Selenium is an important nutrient that needs to be regulated since lack of the nutrient leads to cell abnormalities and high concentrations are toxic.\	SeBP regulates the level of free selenium in the cell by sequestering the nutrient during transport. SeBP acts as a pentamer and delivers the selenium to the selenophosphate synthetase enzyme [1]. Each subunit is composed of an alpha helix on top of a four stranded twisted ss sheet, stabilised by hydrogen bonds [1].	27.90	27.90	28.00	58.30	27.10	27.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.74	0.72	-3.85	3	13	2012-10-01 20:55:33	2008-09-02 09:31:10	3	1	13	5	6	11	0	83.00	52	98.99	CHANGED	MlFEDKFIITTADEIPGLpLYYlGIVSslSD..NVDcIVEsL+EKVKAKGGMGLIAFRITs...ADG.KaLGYGTAVKADEGQFTMA	...MlFEscFIITTAc-IPGlpLYhhGIVSssSD..NVDpIlcsLcEpVpAKsGhGLluFRITs....uDG..KhlGYGTAVKADEuQFsMs.	0	0	1	4
+11357	PF11525	CopK		Copper resistance protein K	Pollington J	anon	pdb_2k0q	Family	CopK is a periplasmic dimeric protein which is strongly up-regulated in the presence of copper, leading to a high periplasmic accumulation [1]. CopK has two different binding sites for Cu(I), each with a different affinity for the metal. Binding of the first Cu(I) ion induces a conformational change of CopK which involves dissociation of the dimeric apo-protein. Binding of a second Cu(I) further increases the plasticity of the protein. CopK has features that are common with functionally related proteins such as a structure consisting of an all-beta fold and a methionine-rich Cu(I) binding site [1].	19.90	19.90	19.90	69.40	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.62	0.72	-4.33	5	22	2009-09-11 07:29:11	2008-09-02 09:51:31	3	1	19	9	13	18	18	71.80	56	78.22	CHANGED	VDcuslcKSl-LKDGSTVHlFKDGKMuMEDKhG+uhpMKcGpVMET+DGQKIhM+GDEVhRLDshL+KcH.p+G	..A..spuscchl.LtDGuTlYIFKDGKMA.Es+aGRAVhhphGsshpTKDGppIshpusEVARLsSLLp+cH....Gs..	0	1	10	13
+11358	PF11526	CFIA_Pcf11		Subunit of cleavage factor IA Pcf11	Pollington J	anon	pdb_2npi	Family	Pcf11 is a subunit of an essential polyadenylation factor in Saccharomyces cerevisiae, CFIA. Pcf11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [1].	21.10	21.10	21.30	21.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.13	0.72	-3.84	10	54	2009-01-15 18:05:59	2008-09-02 10:47:12	3	4	53	2	37	53	1	83.30	29	14.42	CHANGED	s...............ps.spNIQSRNWYLDD.-WVpFKDD-llphoossss.t....................pphppshss.p.ts..hs.pph+spYVVVPsssosMs.+	...tsp....ssstKNlQSRsWYLcDpcWlp...F..+-..--Isuss.pssst.p.ts...................................pptspstss..........................hptpYVlVPpstpsMs.p.........................	0	6	20	34
+11359	PF11527	ARL2_Bind_BART		The ARF-like 2 binding protein BART	Pollington J	anon	pdb_2k0s	Family	BART binds specifically to ARL2.GTP with a high affinity however it does not bind to ARL2.GDP. It is thought that this specific interaction is due to BART being the first identified ARL2-specific effector. The function is not completely characterised [1]. BART is predominantly cytosolic but can also be found to be associated with mitochondria. BART is also involved in binding to the adenine nucleotide transporter ANT1 [2].	20.90	20.90	20.90	21.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.62	0.71	-4.32	32	294	2009-01-15 18:05:59	2008-09-02 10:47:57	3	6	116	4	198	272	4	113.80	29	40.86	CHANGED	hs..cpchlhpplhpaltSs..WpsslpsFh-ppC..hhF--p...-EsplphpplapcYppll-phlpphlp........phuls.cpatpsl........................p.tpppphtpslhp.lhshpDFphF+chMlppNh-l-hpu	....................................tt....c.chlhttl.shlhsst.aph.hpsFh-pps..............hF-.cp...............-E....sKLpYopIapc.YppLlEchl-phLp........t.Ghs..ppFtpsh.....................................ttcschst...s.lhp..llshsDFhhFKpMMlphphEhph..........................................	0	84	104	150
+11360	PF11528	DUF3224		Protein of unknown function (DUF3224)	Pollington J	anon	pdb_2ooj	Family	This bacterial family of proteins has no known function.	25.00	25.00	27.50	29.70	21.10	18.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.47	0.71	-4.65	11	250	2009-01-15 18:05:59	2008-09-02 12:59:52	3	1	238	4	66	200	15	131.80	34	97.93	CHANGED	Mphp..hhGsFplohWsE..oshs-ssss..hspsplspsa.pGDlcGpSplcaLhsY......pu.tuuAsaVGhEphpGslsG+pGoFVLQHpGphspGssssshs.lV.sSGTupLtsLsGshshshss.ssp.u.cFphshtsu	...............................hp.......puoFoVspWsE..............ps.l..ss...t...s.......c..s.h.s...........l...........spAslshph.sGsLpG.p.u.ps.EYLhsY.......su..hpusAphl..Ga.+....FcG.shtG.+pGoFs.hpcp..Gsa.s.pG.t.h...c.s..s..hp..ll..puTG-LtGL...sGshshphsp..spc..hhpath.....h............	0	28	48	56
+11361	PF11529	AvrL567-A		Melampsora lini avirulence protein AvrL567-A	Pollington J	anon	pdb_2opc	Family	AvrL567-A is a protein from the fungal pathogen flax which induces plant disease resistance in flax plants [1]. The protein has a novel fold [1].	19.30	19.30	20.30	69.80	18.00	19.10	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.57	0.71	-4.16	3	13	2009-01-15 18:05:59	2008-09-02 13:09:21	3	1	2	2	1	14	0	126.90	81	84.57	CHANGED	MEDVPAELTGVSEGYTRFYRSPTASVTLSGLVcVKWDNEQMTMPLFKWIGGEQAEELHFCVHIAHSSGRRLNpARTLGTVNSNMDQHWVEAYRSSGVTRCTIQDCHLFANDIPNFPDYIKIKLVPKT	.........MEcVPAELTGVSEGYTRFYRSPTASVsLSGLVcVKWDNEQMTMPLFKWIGGEQAEELHFsVHIAHSSG.+LNpARTLGTVNSNMDQHWspAYRsSGsTRpTIQDpHLFANDI...PNFPDYIKIKLVPKT.....	1	1	1	1
+11362	PF11530	Pilin_PilX		Minor type IV pilin, PilX	Pollington J	anon	pdb_2opd	Family	PilX is a protein from Neissaria meningitidis which is crucial for the formation of bacterial aggregates and adhesion to human cells [1]. The structure of PilX is similar to all pilins as it has the common alpha/beta roll fold. PilX subunits have surface-exposed motifs which are thought to stabilise bacterial aggregates against pilus retraction. It also illustrates how a minor pilus component can modulate the virulence properties of pili which have a simple composition and structure [1].	25.00	25.00	35.30	34.70	23.90	23.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.47	2	59	2009-01-15 18:05:59	2008-09-02 13:32:49	3	3	58	6	2	56	0	126.50	71	79.05	CHANGED	SYIEKGYQSQLYTEMVGINNl.KQFILKNP.DDNpTlKSKLcIFVSGYKMNPKIAcKYsVSV+FVstEKPRAYpLVGVPpsGTGYTLSVWMNSVGDGYKCRDAsSApAa.-TLSuDsGCEAFSNRKK	.SYIEKGYQSQLYTEMVGINNlhKQFILKNPh.DD.NQsIKoKLEhFVSGYKMN..PKIAcKYsVSV+...F..V..s..tE........KsRAYpLVGVPKsGTGYTLSVWMNSVGDGYKCRDAASAcAapETLSuDsGCEAFSNRKK..........	0	1	1	1
+11363	PF11531	CARM1		Coactivator-associated arginine methyltransferase 1 N terminal	Pollington J	anon	pdb_2oqb	Family	CARM1 is an arginine methyltransferase which methylates a variety of different proteins and plays a role in gene expression. This is the N terminal domain of the protein which has a PH domain, normally present to regulate protein-protein interactions.A molecular switch is also present on the N terminal domain [1].	20.40	20.40	20.50	21.20	19.90	20.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.60	0.71	-4.35	3	78	2009-01-15 18:05:59	2008-09-02 14:17:24	3	4	42	10	39	69	0	91.60	59	17.53	CHANGED	M...AAVSVFPGVRLLSIGDANGEIQRHAEQQsLRLEVRAG.DuAsIALaNsE-VCVFKCTVoRETECSRVGKQSFIITLGCNSVLlQFATPADFCSFYNILKoCRGpcuERSVFSE	................................................................................................h.stE-V....CVFKCSVSRETECSRVGKQSFIITL.GCNSVLlQFATPsDFsSFY.N.ILKsCRGHshE+SVFSE....................	0	8	12	22
+11364	PF11532	HnRNP_M		Heterogeneous nuclear ribonucleoprotein M	Pollington J	anon	pdb_2ot8	Family	HnRNP M is a splicing regulatory factor that binds to the auxiliary RNA cis-element ISE/ISS-2 which promotes splicing of exon IIIb and silencing of exon IIIC in the fibroblast growth factor receptor 2 (FGFR2) [1]. By binding to ISE/ISS-3, HnRNP M plays a role in the regulation of alternative splicing in FGFR2 as it induces exon skipping and promotes exon inclusion [1].	20.70	20.70	22.70	23.10	20.30	18.30	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.02	0.72	-7.44	0.72	-3.85	3	73	2009-01-15 18:05:59	2008-09-02 14:30:45	3	4	35	2	30	54	0	29.50	80	4.60	CHANGED	-psoQNEKRKEKshKR.GGNRFEPYSNPsKR	........ERPsQNE..KRKEKNIKR..GGNRFEPYuNPTKR.	0	1	3	11
+11365	PF11533	DUF3225		Protein of unknown function (DUF3225)	Pollington J	anon	pdb_2owp	Family	This bacterial family of proteins has no known function.	20.80	20.80	20.80	20.90	20.70	20.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.69	0.71	-4.45	24	251	2012-10-03 02:27:24	2008-09-02 14:42:48	3	5	240	6	86	307	27	123.10	51	80.95	CHANGED	hpINtPcVlAEVsAAFtcYEpALssNDVssLDtLFWssPcTlRYGsuENLYGh-tI+AFRtsRsusuLsRplh+TslTTFGcDhAssssEFpR..cGus.RlGRQpQTWlRh.s-.GW+lVAAHVSlh.ps	..........................................................pIshPtllAEVoAAFhcYEpAL....luNDlssLDtLFWpss+.TV...R.a.G..........s.u..E.N.LYG.h.-sI.+.A.F...Rt.u.R...sus.......G...h...s..R...p.L.......t........c....T..sITT......FG..c.....D.h.....A....s...s..o..T..E..FpR........cG..os....+l.G..R..Q........Q.....T..WlR....h......ss....G........W+lVAAHVSLh..s......................................................	0	14	41	60
+11366	PF11534	HTHP		Hexameric tyrosine-coordinated heme protein (HTHP)	Pollington J	anon	pdb_2oyy	Family	HTHP is from the marine bacterium Silicibacter pomeroyi and has peroxidase and catalase activity. HTHP consists of six monomers which each binds a solvent accessible heme group and is stabilised by the interaction of three neighbouring monomers [1]. The heme iron is penta-coordinated with a tyrosine residue as proximal ligand [1].	25.00	25.00	25.70	32.10	24.00	23.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.56	0.72	-3.91	9	36	2009-01-15 18:05:59	2008-09-02 15:55:30	3	2	34	8	21	45	5	69.40	51	80.69	CHANGED	hs-sWLPoLhTsTPpEGapLAVKhARluVKhTQPDs-lRppLRssYucDAsuLIAsSpVlAsaFATlAAANsYW+	..........hsoLhTsTPpEGhpLAlKluRhulKhTQPDs-lRcpLRs.YupDustLIAsSQVVAhcFtTlAAANNYW+......	0	6	12	18
+11367	PF11535	Calci_bind_CcbP		Calcium binding	Pollington J	anon	pdb_2p0p	Family	CcbP is a Ca(2+) binding protein which, in Anabaena, is thought to bind Ca(2+) by protein surface charge. When bound to Ca(2+), the protein becomes more compact and the level of free calcium decreases. The free Ca(2+) concentration which is regulated by CcbP is critical for the differentiation process [1]. Calcium signalling is widespread in bacterial species, and prokaryotic cells like eukaryotes are equipped with all the elements to maintain Ca2+ homeostasis [2].	21.50	21.50	21.90	21.50	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.32	0.72	-3.79	17	53	2009-12-03 17:50:01	2008-09-02 16:15:08	3	2	45	3	25	55	5	97.80	26	66.48	CHANGED	cRIthEIlVDAY........stcEpthGWYpaL--sLphPFpAhhht...............tpVpVluhu.p-ps.tphhVplph....spcphslsLppLtshcsDspopp........AltDW+YWls	..................................................th..chhVDsY........stpEphhuWhtaLp-plphPFpuhhht.......................s....tcpVpVluhssppsp.tthhVplch....sccphslsLs-Lcsh-ssspspp.............slsDapaWh..................	0	7	19	22
+11368	PF11536	DUF3226		Protein of unknown function (DUF3226)	Pollington J	anon	pdb_2p62	Family	This archaeal family of proteins has no known function.	20.80	20.80	20.80	21.00	20.00	20.70	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.51	0.70	-4.92	4	17	2009-01-15 18:05:59	2008-09-02 16:23:43	3	2	15	2	12	23	0	205.50	28	76.19	CHANGED	h+lLllEG+TDsuFFhsllKKLYGF+Eu+..scsl.hhE...Kht-hs+slsLcKDshtLlVhHupGKsplh+sLpshLcAlch.hh.slchlGlARDVDp-c-lhsWspShl+puuFEs+hsssalllp..slKIhPhGIGpl...sFst..l-hKK.ELEhlhshLAKt-ulLEKh+sSlpuLppDhGRKLpPKDlMHlLuIApsasGDshSGLYcpFItc.I+cN+chV.chLs.hslL.hLshhh	....plLhlEG+TDspFFpslhKKLatF..+Eucthstpl...hh-.............phhEhsph.hL..c+..-sshlslhsupGpsslh+sLtshlcu.hcl.hthplptlGlshDlDcsc-s.shtp.hhp.ttap.t.tshhhhl...th.lhshhhG.h...shp.t..l..-.+K.plE.hhhhLhctpuhLp+hc.ulp.Lp.shtcKLpPK-lhalh..A.tahGs.hpGhYc.al.h.hh.php.l.p.hs..t.........th........................................................................................	0	2	2	8
+11369	PF11537	DUF3227		Protein of unknown function (DUF3227)	Pollington J	anon	pdb_2p9x	Family	This archaeal family of proteins has no known function.	21.20	21.20	23.90	23.80	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.19	0.72	-3.91	2	9	2009-09-10 21:06:52	2008-09-02 17:19:47	3	1	9	4	8	11	0	96.40	31	95.49	CHANGED	hp.s+sllstThhphLpphuPth.ssLEAaLpAphNtslElAhEDPtKFhcAVpcLFGEauAphh.hsll.cLp.h.sKp....shEpllt.lKKhh....G	.............p.sc-llspslpthl+cluPsLcslLEh+L+uphsK.Gh.ElAhEDPpcF+-AVS+LFGEa.SA+LlthhllscL+.hlt.p.phpsLEpllp.l+..............................	1	2	4	6
+11370	PF11539	DUF3228		Protein of unknown function (DUF3228)	Pollington J	anon	pdb_2pd0	Family	This family of proteins has no known function.	25.00	25.00	207.50	207.30	21.00	19.10	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.37	0.71	-5.21	11	64	2009-01-15 18:05:59	2008-09-02 17:22:04	3	2	62	6	40	71	54	192.10	49	89.79	CHANGED	hplsL-sFsh+Qacpp.hpsshIs.hspEpFlp+lNchhc.sshcllDGYAPFCKHlFlcNFT-sp......stslcITscNc+LL....+ouY.ARs-pELPVLsRWFshpsVp.ppl..ApYLDlILYS+EQlpKEssthtp...........ssDauIlSIKsQspsaElPMtPITMhRNAL.l-EGGSGVsLDREcYhcSVcaWpcaAslhs	.........plsLssFAhpph.sps....hpsstIp.hs.-pFlp+lN-t.....s...shcll-GYAPFCKhhhlcN.aT.us+......shslsITscNcHLL....RSGYpARsspELPVLsRWF..cs..Vc.ssl...............ApYLclILYSREQlsKEsssh...............-ucWGIlulphpsEs.ElPMsPITMhRNALGlEEGGSGVPLDR-tYpcSVtaWcppAshhs.	0	21	28	36
+11371	PF11538	Snurportin1		Snurportin1	Pollington J	anon	pdb_2p8q	Family	Snurportin1 is a novel nuclear import receptor which contains an N-terminal importin beta binding domain which is essential for its function of a snRNP-specific nuclear import receptor [1]. Snurportin1 interacts with m3G-cap where it enhances the m3G-cap dependent nuclear import of U snRNPs in Xenopus laevis oocytes and digitonin-permeabilized HeLa cells [1].	20.80	20.80	20.80	21.00	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.49	0.72	-8.09	0.72	-4.18	6	77	2009-01-15 18:05:59	2008-09-02 17:22:04	3	3	55	15	45	67	0	40.00	63	12.48	CHANGED	HPRLSpYKsK.tsuh-QucRRR+hLElQKp+R..LDahs+uR+	....HPRLS.Q....YKuK..aSuL.EQSERRR+LLELQKsKR.....LDYVNHARR.........	1	12	17	28
+11372	PF11540	Dynein_IC2		Cytoplasmic dynein 1 intermediate chain 2	Pollington J	anon	pdb_2pg1	Family	Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules [1]. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex [1]. 	25.00	25.00	26.60	26.90	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.25	0.72	-4.58	10	218	2009-01-15 18:05:59	2008-09-03 09:13:31	3	4	80	7	86	257	0	32.80	60	5.67	CHANGED	u++sh+LuhScVsplDFsPKEsVoYSKETQTss	.....tRtshKLGhuKlTQVDFPPRElVoYoKETQTPs..	0	24	30	53
+11374	PF11542	Mdv1		Mitochondrial division protein 1	Pollington J	anon	pdb_2pqn	Family	Mdv1 is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation [1]. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependant devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly [2].	25.00	25.00	28.00	27.00	23.40	22.30	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.48	0.72	-4.04	2	12	2009-01-15 18:05:59	2008-09-03 11:17:30	3	2	12	3	4	11	0	49.60	90	7.29	CHANGED	DADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY	..DADGKLLTEGGEDENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY...	0	1	1	2
+11375	PF11543	UN_NPL4		Nuclear pore localisation protein NPL4	Pollington J	anon	pdb_2pjh	Family	Npl4 is part of the heterodimer UN along with Ufd1 which is involved in the recruitment of p97, an AAA ATPase, for tasks involving the ubiquitin pathway. Npl4 has a ubiquitin-like domain which has within its structure a beta-grasp fold with a helical insert [1].	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.37	0.72	-3.70	9	177	2012-10-03 10:59:06	2008-09-03 11:20:48	3	14	147	2	124	200	2	78.60	30	14.25	CHANGED	MstphllRVQSs-GhKRlphopppThsphhcKVtcphuFspp.tFulah-RNposEl.uSpspplp.ltl+HGDhL.aLh.s	.................hllRlpSs-GhcRl.p.s..s.t..pp.T....huplh....ccltcp.h..s.hsss...u...h.sl.a..hs........c........s...........t......s...........sc.......l.t........u.......s...s.......s.p..o....L....s........LtlpHGDhl.aLh...............................	0	46	72	100
+11376	PF11544	Spc42p		Spindle pole body component Spc42p	Pollington J	anon	pdb_2q6q	Family	Spc42p is a 42-kD component of the S.cerevisiae spindle body that localises to the electron dense central region of the SPB [1].Spc42p is a phosphoprotein which forms a polymeric layer at the periphery of the SPB central plaque. This functions during SPB duplication and also facilitates the attachment of the SPB to the nuclear membrane [1].	21.10	21.10	21.30	21.50	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.69	0.72	-4.05	5	30	2009-09-11 12:37:10	2008-09-03 12:45:58	3	3	26	2	21	27	0	72.90	38	16.96	CHANGED	NcLIKQNKELpsKLcEKQ-EI-RLNlLlGSLRAKLIKYTELNKKLpc-tQstQpp.sslscsto-stsDulhhsc+u	.......NchlpQNK-LphKLc-KQsEI.cLpplspoLRuKL.KYs-lsKK..LEcpshshphp.sshppphs-..ss........................................	0	3	9	18
+11377	PF11545	HemeBinding_Shp		Cell surface heme-binding protein Shp	Pollington J	anon	pdb_2q7a	Family	Shp is part of a complex which functions in heme uptake in Streptococcus pyogenes. During which, Shp transfers its heme to HtsA which is a component of an ABC transporter. The heme binding region of Shp contains an immunoglobulin-like beta-sandwich fold and has a unique heme-iron coordination with the axial ligands being two methionine residues from the same Shp molecule [1]. Surrounding the heme pocket, there is a negative surface which may serve as a docking interface for heme transfer [1].	25.40	25.40	26.10	31.60	23.20	25.30	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.96	0.71	-4.40	3	63	2009-01-15 18:05:59	2008-09-03 13:00:48	3	2	61	2	4	59	2	148.50	42	44.61	CHANGED	ADKGplYoClIpRsYRHPVSGQIEDSGGEHuF-IGQGMVEGTVYSsGMLEVTDAG-lYLTFRMSLADYSGNYQFWVQPGGTGuFQAsAYulTpsGTDTNGTTtDIAIuLPoVNoVVRGSMYVEPMGREVVFYLSPSELpEGYSGDMlAohVT	......................tuplYsshlppsYcHPloGpIED...uG...Gptuh....sIGQGMVEusVausuhLEsoDuG+lhLThRhuLADa...sushp...FhlQ.s.sGsG...uFpuVshslTppGoDs...NGTT........tD.ltIplPohNslIRuSMaVEPMGR-VlFYl..ssuph...pt.ossh.s.h........................	0	1	2	3
+11378	PF11546	CompInhib_SCIN		Staphylococcal complement inhibitor SCIN 	Pollington J	anon	pdb_2qff	Family	SCIN is released by Staphylococcus aureus to counteract the host immune defense. The protein binds to and inhibits C3 convertases on the bacterial surface, reducing phagocytosis and blocking downstream effector functions by C3b deposition on its surface [1]. An 18 residue stretch 31-48 is crucial for SCIN activity [1].	21.30	21.30	22.10	21.80	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.37	0.71	-4.23	4	473	2009-01-15 18:05:59	2008-09-03 14:17:44	3	1	163	22	5	62	1	111.40	56	97.12	CHANGED	MKhKKYIlAGTLAlLLuoTulssl-tNcAsASo..ph.hpspapcc+lA-EL+oLLsposVNcLAsGSLNsYYKRsIhhspY+AKuALKopsFspMu-AKhtLEpIYcEIDEhlpp	......................MKIKKYIlAGTLAlLLuoTulssl-KNEAsAST..ph.hpspYQcc+LA..-EL+oLLsp..osVN.cLAsGSLNsYYKRsIhhupY+.AKuALKoKsFcpMo-AKhpLEpIYsEIDEsL+S.......	1	4	4	5
+11379	PF11547	E3_UbLigase_EDD		E3 ubiquitin ligase EDD	Pollington J	anon	pdb_2qho	Family	EDD, the ER ubiquitin ligase from the HECT ligases, contains an N-terminal ubiquitin-associated domain which binds ubiquitin. Ubiquitin is recognised by helices alpha-1 and -3 in in the UBA domain. EDD is involved in DNA damage repair pathways and binds to mono-ubiquitinated proteins [1].	25.00	25.00	46.70	45.50	23.00	22.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.53	0.72	-4.47	3	94	2009-01-15 18:05:59	2008-09-03 14:33:28	3	7	74	4	61	100	0	52.30	84	2.12	CHANGED	suIPAuhVPEELIuQAQVVLQGKSRNVIIRELQRTNLDVNLAVNNLLSRDDED	.........slPAoslPEELISQAQVVLQGKSRsVIIRELQRTNLDVNLAVNNLLSRDDED..	0	21	26	44
+11380	PF11548	Receptor_IA-2		Protein-tyrosine phosphatase receptor IA-2	Pollington J	anon	pdb_2qt7	Family	IA-2 is a protein-tyrosine phosphatase receptor that upon exocytosis, the cytoplasmic domain is cleaved and moves to the nucleus where it enhances transcription of the insulin gene [1]. The mature exodomain of IA-2 participates in adhesion to the extracellular matrix and is self-proteolyzed in vitro by reactive oxygen species which may be a new shedding mechanism [1].	20.50	20.50	21.20	21.10	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.85	0.72	-4.07	6	114	2009-01-15 18:05:59	2008-09-03 14:53:12	3	6	52	8	47	134	0	83.70	52	9.80	CHANGED	-EpaGYIlT-pcPLSs-cGl+LhElLAchl+lsoosFhslpVlGPAVTF+lRsNtQNloTADVsctAsssKspLEppoGL+ILQoGlup+s	.............t.EcaGYIlTcpcPL.oh.ttGh+LlEhLAchlchsousFhsISVVGPAlTFRlRpNp.QNlohADVsppAs...s...KscLEspTGLpILQTGVGpR..........................	0	6	10	24
+11381	PF11549	Sec31		Protein transport protein SEC31	Pollington J	anon	pdb_2qtv	Family	Sec31 is involved in COPII coat formation as it forms through the sequential binding of three cytoplasmic proteins: Sar1, Sec23/24 and Sec13/31. Sec13/31 is recruited by the pre-budding complex and polymerisation of Sec13/31 occurs to form an octahedral cage that is the outer shell of the COPII coat [1]. Sec13/31 is a hetero-tetramer which is organised as a linear array of alpha-solenoid and beta-propeller domains to form a rod in which twenty-four copies assemble to form the COPII cub-octahedron [1].	25.00	25.00	25.30	48.00	23.70	19.20	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.58	0.72	-4.32	6	24	2009-01-15 18:05:59	2008-09-03 15:43:24	3	6	22	1	15	26	0	50.20	66	3.95	CHANGED	sssPssssNVhSGQTPHLN+KANDGWNDLPLhVKEKPoRAKPVoVAPsuhh	......ss.PPh..NshSGQTPHLN+KANDGWNDLPLcVKE...KPSRAKAVSVAPssl...	0	1	7	14
+11382	PF11550	IglC		Intracellular growth locus C protein	Pollington J	anon	pdb_2qwu	Family	IglC protein is involved in the escape of F.tularensis live vaccine strain [1]. It has been shown that the expression of IglC is essential for F.tularensis to induce macrophage apoptosis [2]. IglC adopts a beta-sandwich conformation that has no similarity to any known protein structure [3].	25.00	25.00	55.40	55.30	21.20	17.70	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.27	0.70	-5.02	2	33	2009-01-15 18:05:59	2008-09-03 16:03:29	3	1	32	2	2	17	0	203.70	95	100.00	CHANGED	MIMoEMITRQQVTSGETIpVRTDPTACIGSHPpsRLFIDSLTIAGEpLDKNIVAIEGG-DVTKADSATAAASVIRLSITPGSINPTISIshGsLIKSsVRsKlpEKlSsILQASATDMKIKLGNSNKKQEYKTD-AWGIMIDLSNLELYPISAcAFSISIEPTELMGVSKDGMpYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAsu	..MSEMITRQQVTSGETIHVRTDPTACIGSHPNCRLFIDSLTIAGEKLDKNIVAIEGGEDVTKADSATAAASVIRLSITPGSINPTISITLGVLIKSNVRTKIEEKVSSILQASATDMKIKLGNSNKKQEYKTDEAWGIMIDLSNLELYPISAKAFSISIEPTELMGVSKDGMpYHIISIDGLTTSQGSLPVCCAASTDKGVAKIGYIAAA.	0	1	1	1
+11383	PF11551	Omp28		Outer membrane protein Omp28	Pollington J	anon	pdb_2r2c	Family	Omp28 is a 28-kDa outer membrane protein from Porphyromonas gingivalis. Omp28 is thought to be a surface adhesion/receptor protein. Omp28 is expressed in a wide distribution of P.gingivalis strains [1].	23.90	23.90	24.50	24.70	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.15	0.71	-4.74	4	100	2009-01-15 18:05:59	2008-09-03 16:20:42	3	2	61	2	16	103	108	175.20	19	45.94	CHANGED	Dshhhc.tsshpptatloGhPsshls.RcthhhS.shsh..hsashslhp....pstssslAIsSthsGpplsVTVpVth-pGso.sh+lV.lYlLENGLlhsQss............hGssl.sasHNcVLRtuhouhh.GDhhsshtshtthohuVslhhstuaNuENhslsAhVsDsss.pshss.+stlsspsDa	............................................................................................................sshPpshhs.R......p........th..h.......p...................t...tsh....t...t.pl...hp..............h.ss..s.....s..lsl.p..s.p..hs......s..s....p..hpls..lps.p...h...t.p.s.s...s.....t..h.+Lh..laLlEDulhu.Qt.s...................sssh..h..ps..Y...sHNHVlRs.....sl.s.u.sh....G-c.l.s.h..ts..ss....p..pshp..hshsls..p..s.h.s.....s......ps...hp...lVAalh....s..sss.....s.pshptth..........................................................................	0	8	15	16
+11385	PF11553	DUF3231		Protein of unknown function (DUF3231)	Pollington J	anon	pdb_2rbd	Family	This bacterial family of proteins has no known function.	27.70	27.70	28.10	27.90	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-4.75	51	448	2009-01-15 18:05:59	2008-09-03 17:01:37	3	3	139	2	115	456	0	159.20	22	94.95	CHANGED	hthhh.....ppsLsusElutlassh.ssshshslhptFhpsscDc-l+phlpcuhcl.upcalctlpplhpc-slslPpua..-s-Vssssss....FoDphhlhalphhspsulssYuhuhuhshRpDlthhatchhtchhphhpcshclhlc+Ghh.pPPhhsspccl	............h........sppcsLpssElhplWshhhssphshshhphFhppspDc-l+p.hlp.p.s.h.c.h.s.ppplcplpplLpppsl..sl.Ps...s...s...cssssh.s.s.ss.....asDthhhthl.shhh.t.tulsshutuhuts.hRpD.l.thhasphhhcphphspchhclhhcK.GWl...PPhh.....................	0	45	112	113
+11386	PF11554	DUF3232		Protein of unknown function (DUF3232)	Pollington J	anon	pdb_2rdc	Family	This bacterial family of proteins has no known function.	20.90	20.90	21.00	21.80	20.00	20.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.72	0.71	-4.30	3	14	2009-01-15 18:05:59	2008-09-04 09:07:04	3	2	14	2	7	16	0	125.40	28	65.53	CHANGED	MhQ.p..usVlSaVupahKuoEpsM-RYK+VlsIsKuDEVAl+LLEGLIDAuTRYFuKVVEMEpRLQTARFRLEGEELR-LTE-LDRSRRhAHEAhISSLHVFNRYlVKEYGE-LpEAGapGGIFP+PEAsRDRIAIAD..WAGELLoGIYE.sR++	.........................................t.h...........................................llpshhpphpcYshhVlch..-spltsh+.chsGp-YR-hsEpLD.+pRoshHssslSsl+ILNRhA-ppt........atss...ps-hsc.t.sIsc..at...............h.................	0	3	4	5
+11387	PF11555	Inhibitor_Mig-6		EGFR receptor inhibitor Mig-6	Pollington J	anon	pdb_2rf9	Family	When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains [1].The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive [1].	25.00	25.00	25.20	25.20	22.60	21.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.65	0.72	-3.58	6	119	2009-01-15 18:05:59	2008-09-04 09:35:41	3	9	40	6	49	99	0	64.70	64	8.47	CHANGED	+PPpVPPR-PL.SpssSRTPSP+u............................Lso..stlMPsTQSFAuDPKYsosKslQtQus-uu	...................pPP+VP..P...RE.PL.S.psSRTPSPhs.....................................LsS..stsMPsTQSFAsDPKYsosps..lQt.uscuu...........	0	2	8	18
+11388	PF11556	EBA-175_VI		Erythrocyte binding antigen 175	Pollington J	anon	pdb_2rji	Family	EBA-175 is involved in the formation of a tight junction, a necessary step in invasion. This family represents the region VI which is a cysteine rich domain essential for EBA-175 trafficking. The structure is a homodimer that contains a five-alpha-helical core stabilised by four disulphide bridges [1].	21.50	21.50	22.80	22.80	19.60	18.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.18	0.72	-3.88	11	128	2009-01-15 18:05:59	2008-09-04 10:54:31	3	10	18	2	19	138	0	77.90	58	8.31	CHANGED	lccTREcIIphSppNhCsNchS.cYCshhccchss.uTCSc-cpKsLCCSISDYCLKYFshsSpcYYsCh++EFpDPsYcCF	.lKsTREpIIhhSph.pKCNNslSlcYCsolcDKISS.sTCS+E+oKNLCCSISDaCLpYF-h.ShEYasCMK+EFcsPpYpCF.	0	5	7	16
+11389	PF11557	DUF3233		Protein of unknown function (DUF3233)	Mistry J	anon	Pfam-B_5068 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.50	22.50	22.70	43.60	21.40	22.40	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.98	0.70	-5.61	6	107	2009-12-15 10:43:27	2008-09-04 10:56:04	3	2	103	0	13	62	1	315.40	57	98.66	CHANGED	Mlphsh.....+l......s...huhlLlhstuspAcsh.ch.....lpsclEpsFooulVLoDS-sIThGIsDFDPNchlchcpps....hGos-SIphRpphoVYoLPa...ThsLo--.su.............apHpLpsRLShlpt-s-lplhsssu.oDsh+-psaGuhltYshpYploEsWTlssuhGsHLMaY+NsaoYNsch.pphtslLDGhhVNsSAhAhllEPNlchpYppcpsWGKWcasSoh+YFhGpuaGsAss.upsuNPcGWhlsNulphaYshschtctsQulYsphKRVDlGGDss-sLGTcHYYEhulGWLhssPphhphlDNlGIGlohNhGSAL+GGSIVLaFNc	..........................................................h.Sho...uoA...cS...h.Dh.....IQcaLEQAFSSSVVLSDSDVFTsGFNNFDPN-WFcsDN-N....LGTsESIEpRK+aKSSTLPh...TluLSE-.-A.............haQHQLFFRLSAsVID--LsIus..h.s.u...co-+aRpSVLGGulhYRYQY+LT-HWTLTPAIGTHLlYYRNohTYNNPphKh.L.hSsLDGLLVNThAWAsLlEsNlKlQY-EEKSWG+W+ASSuWHYFsGaGWGcANN.G-VGNPEGWYlANoLTGhYDF..TQlGRSVQSIYuSIKRVDVGusspEPLGToNYYEAShGWLMTPPFEh-hVDNIGlGLTFNYGSAhKGGSIVLFFNQ..........	0	2	4	9
+11390	PF11558	HET-s_218-289		Het-s 218-289	Pollington J	anon	pdb_2rnm	Motif	This family of proteins is residues 218-289 of Het-s, a protein of Podospora anserina. Het-s plays a role in heterokaryon incompatibility which prevents different forms of parasitism [1]. This region of the protein is the C-terminal end and is unstructured in solution but forms infectious fibrils in vitro which has a structure consisting of a left-handed beta solenoid which contains two windings per molecule [1].	25.00	25.00	30.00	28.90	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.86	0.72	-4.00	5	15	2009-01-15 18:05:59	2008-09-04 11:24:25	3	1	9	18	14	19	0	63.00	33	22.32	CHANGED	KlssIsVRN.s+cIpopEsAKV+LGNsaosuALusAIthsDRToNcs-oVpuKGsSsVHIGN+YG	...KlpsIsu+NpA+cIpsE-pA+lclGNsaSpssLspuht...lsDpTpNpV-sVsA+ssS+VpIGNpYG	0	0	7	13
+11391	PF11559	ADIP		Afadin- and alpha -actinin-Binding	Wood V, Coggill P	anon	Pfam_B017401 (23.0)	Family	This family is found in mammals where it is localised at cell-cell adherens junctions [1], and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules [2]. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.	29.90	29.90	29.90	30.10	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.66	0.71	-4.31	24	277	2009-01-15 18:05:59	2008-09-04 11:38:10	3	9	197	0	184	254	1	144.40	26	27.58	CHANGED	cpshpaINppLhohGasp.tthhsss............................phshstllNslasLlttpc+shctpEslppphpphpu-hpphpsshp+Lc.sphpthp+Ehs.thpppc+plpppl+shpppl+sp+--lp+hpshlpshcoQhsp-h+++-pEhpKLKc+Lpp	...........................................ps.pYlsppLh.shGh.p.hp..p.t..............................thshspllNsl.cLl.htp..c......+shptpEslpsphpplpu-hs+hpsphp+L........c.pplpptcRchs.thppp-pphpsph.....+..shpppl+pt+-...Elp+hps......hlpphps...Qhsp-h+++-pEhp+LKc+Lpp.........................................	0	61	101	146
+11392	PF11560	LAP2alpha		Lamina-associated polypeptide 2 alpha	Pollington J	anon	pdb_2v0x	Family	LAPs are components of the nuclear lamina which supports the nuclear envelope.LAP2alpha is a non-membrane-associated member of the LAP family which is unique. This family of proteins is the C terminal domain of LAP2alpha which consists of residues 459-693 and constitutes a dimeric structure with an antiparallel coiled coil. LAP2alpha is involved in cell-cycle regulation and chromatin organisation and preferentially binds to lamin A/C [1].	25.00	25.00	31.50	30.70	21.90	19.00	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.61	0.70	-5.18	2	25	2009-01-15 18:05:59	2008-09-04 11:50:26	3	3	17	2	9	47	0	209.20	60	33.77	CHANGED	AKoVVSHSLTTLGlEVuK..sQHDKI-ASE.SFPhHESILKVlEEEWQQlDRQLPSlAC+YPVSShEAspILSVPKVDDEILGFISEATPhuuhQAuSTESCsppLDLALCRuYEAAASALQIAsHTAFVAKuhQADISQAAQIlsSDPScspQALtILs+TYDAASYlC-AAFDEV+MuApsMGsuThGRRYLWLKDCKIs.ASKNKLsssPFKGGTLFGGEVpKVIKKRGNKp	..............AKTVVScSLTTLGlEhSK.QSQHDKIDASE.SFPhHESILKVIEEEWQQlDRQLPSLACKYPVSS+EATpILSVPKVDDEILtFISEATP.sGlQAuSTESCsKpLDLALCRsYEAAASALQIAoHTAFVsKAhQADISQAAQILSSDPo.cttQALsILS+TYDAASalC-AAFDEV+MuA+oMGsSTsGRRaLWLKDCKls.ASKNKLsssPFKGGTLFGGEVpKVIKKRGNK.......	0	1	1	1
+11393	PF11561	Saw1		Single strand annealing-weakened 1	Wood V, Coggill P	anon	Pfam_B03980	Family	This family of yeast proteins is involved in single-strand-annealing, or SSA. SSA entails multiple steps: end resection and ssDNA formation; annealing of complementary ssDNAs; removal of 3' single-stranded non-homologous tails; gap fill-in synthesis; and ligation. Saw1 in combination with Slx4 catalyses the 3' non-homologous tail removal during recombination. Saw1 interacts physically with Rad1/Rad10, Msh2/Msh3, and Rad52 proteins, and works by targeting Rad1/Rad10 to Rad52-coated recombination intermediates [1].	20.50	20.50	21.80	21.00	19.20	18.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.34	0.70	-4.95	9	45	2009-09-11 06:58:03	2008-09-04 13:11:48	3	2	41	0	30	45	2	210.00	28	91.69	CHANGED	Mssslshl+lusshllPlRlFlpR+plLt........sptshhp...lsppsIlpLpp.shplhLSpsDlpuLlspl+c-Ll.llhp.............................hppss.......hhshplpshcchs+hchpl+hhhphclslhl.shcclthlpph..h.h...................hsptstsLhhhspph.h............................p.ppstcp-...cK..lpaph+ssh...sltcsIclYVh	...MssplshlplspshlLPlRIFlNR+plLp.....................sp.o.suohhpt......P.lsspSIIsL+s.ss+IhLSppDhps.Lss-I+c-LLhIla.-hss....t.....................................................................................t...phl.c...l.hssspsp...phhssplpshpchsKhphpL+hctphclcIh.lsshccl.s.plRchlhh......................shs.ps.pL.hh.pph.h.....................hl.-stp.t..................t.pts.pp-.....K.....lpahhps.h....slschIclal..............................................................................	2	7	17	28
+11395	PF11563	Protoglobin		Protoglobin	Pollington J, Eberhardt R	anon	pdb_2veb	Family	This family includes protoglobin from Methanosarcina acetivorans C2A. It is also found near the N-terminus of the Haem-based aerotactic transducer HemAT in Bacillus subtilis (Swiss:O07621). It is part of the haemoglobin superfamily. Protoglobin has specific loops and an amino-terminal extension which leads to the burying of the haem within the matrix of the protein. Protoglobin-specific apolar tunnels allow the access of O2, CO and NO to the haem distal site [1]. In HemAT it acts as an oxygen sensor domain [2].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.62	0.71	-4.57	104	1086	2012-10-01 21:46:00	2008-09-04 14:07:44	3	53	846	19	390	1089	31	155.20	20	36.20	CHANGED	tpsclpthhpalshs...pcDhphLpphpshlpstlssll-taYpclhph.sphschhss......................psplp+h+pthppalpcl......hsus...hcttahcthpc.lGthHs............clslc.pahhushshlhptlhptlhpp............hshpchtthlpAlsKllhl-.slhhpsYhcstpp	...............................h.........thhths...ttphthltp.ht.thh.ts.phctlsppFY.ch.lt.p.p..Pc.h.tp.hlss.............................pps.hpcLK.pshpp..al.h.p.l......hsup........hD..p..c.a...l.p.h.p...pp...luphHs..............+IGls....schhhsuaphlhchlhthlhsp........................................................hs.htchhphhpshh+hl.lshplhhpsY.t....h..........................................................	0	140	270	329
+11396	PF11564	BpuJI_N		Restriction endonuclease BpuJI - N terminal	Pollington J	anon	pdb_2vla	Family	BpuJI is a restriction endonuclease which recognises the asymmetric sequence 5'-CCCGT and cuts at multiple sites in the surrounding area of the target sequence. This family of proteins is the N terminal domain of BpuJI which has DNA recognition functions. The recognition domain has two subdomains D1 and D2. The recognition of the target sequence occurs through major groove contacts of amino acids on the helix-turn-helix region and the N-terminal arm [1].	25.00	25.00	112.60	112.60	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.03	0.70	-5.46	2	14	2009-01-15 18:05:59	2008-09-04 14:28:20	3	2	13	1	3	15	0	256.30	42	61.35	CHANGED	M..sPEc..FRhph.Rs+hKN.l-NlLshhAs.Is.ls.hsKtpFspphNshlhphhGp.-pTcKTlsNaRTEIu.pLFGMhhEc-thlasusRspchhEDpD..tFFKshhapFpaPsGh.K.scllchsthtlQh+.h.YlLplhh...pA-ppsI.Loc--lAahlhNsLpshps+..slElhp+IhEsRusclshcs+..Gc.hpYu....+-.LsYh.lAsLlplpGshhKlN.hEtpsIN...pFhtscspFsuYt..h....To.-Dh+sFhpsW.pY...VNpchu	...Y.sP-cYaaRlHH.RPRFKs-lEsVLlahAspIS.ls.LscppFspphNphlppah....s.N....scps.pKTIsNWRTEIu.uLFGhhh......EcpG.hlh.suspApcLs-sQDL.cFFKpFhasFpYPuGHhKsppIlchhp.slpFK.....PspalLpLht...pu.cp...+..shhLTc-EluahlaNDLRsspc+pssh.Elhp+IhcNRtsclta-sp................GDVhRYA....pDILDYM.lAsLl.plpG.s..p....ahlNs.EppuIs...cahpssshFcsYsphht.tpsohc-l+phcptWF-Y...VNpt.........	0	2	2	2
+11397	PF11565	PorB		Alpha helical Porin B	Pollington J	anon	pdb_2vqg	Family	Porin B is a porin from Corynebacterium glutamicum which allows the exchange of material across the mycolic acid layer which is the protective nonpolar barrier. Porin B has an alpha helical core structure consisting of four alpha-helices surrounding a nonpolar interior. There is a disulphide bridge between helices 1 and 4 to form a stable covalently bound ring [1]. The channel of PorB is oligomeric [1].	21.10	21.10	21.10	30.60	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.33	0.72	-3.78	4	21	2009-01-15 18:05:59	2008-09-04 14:58:00	3	1	13	16	6	20	0	103.70	35	77.37	CHANGED	AtsAslsSo..sp-lsshhDhhsCsILcsuLstsGLscEspppsELAAsLcspus.........lG-hs.......suhuuclADRAQTCGIVcsD......TtLppLSSNLSS	...................u..Aslsss..spthsshlsshsCulLcs...uLtss.....G..lhcEsoTRsELAtsLcspus...ss..hsplsshs.......sshuuplADRA.TCGIVKsD.......o.Lp...tLSSNhSs..................	0	3	4	6
+11398	PF11566	PI31_Prot_N	Inhibitor_PI31;	PI31 proteasome regulator N-terminal	Pollington J	anon	pdb_2vt8	Family	PI31 is a regulatory subunit of the immuno-proteasome which is an inhibitor of the 20 S proteasome in vitro.PI31 is also an F-box protein Fbxo7.Skp1 binding partner which requires an N terminal FP domain in both proteins for the interaction to occur via the FP beta sheets. The structure of PI31 FP domain contains a novel alpha/beta-fold and two intermolecular contact surfaces [1]. This is the N-terminal domain of the members.	18.50	16.60	18.70	17.10	18.20	16.50	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.94	0.71	-4.63	42	340	2009-01-15 18:05:59	2008-09-04 15:45:36	3	5	214	2	203	338	1	146.10	22	42.76	CHANGED	hh.htshpsslpsstDslshhlHhhhhps.sFchh...t........................lscspphpppp..........................t..lPttWst.s.ssYshpYtpsts..shpalLpshthssphllps...lshs.spphsshplsspcalst..................pptsshsshhpp.......hpcLhshhcpp................................................llp.lhsshpptth	..............t.......psshpsspDulhhhlHhhhlps.Gahhh...s........................hscssphpstp...........................................hhP.ppW..st..spssYshpYtcs...........s...stphllpshh.hss.tlllss.........lsht..scplpplpl.psccalsp..............................pp.sshsph.hts........................hpcL.phhcsp................................................ll..lhsthpp.....................................................................	2	59	93	148
+11399	PF11567	PfUIS3		Plasmodium falciparum UIS3 membrane protein	Pollington J	anon	pdb_2vwa	Family	UIS3 is a membrane protein essential for sporozoite development in infected hepatocytes. This family is 130-229 of the Plasmodium falciparum UIS3 protein which is compact and has an all alpha-helical structure.PfUIS3(130-229) interacts with lipids, phospholipid lysosomes, the human liver fatty acid-binding protein and with the lipid phosphatidylethanolamine. The interaction with liver fatty acid-binding protein provides the parasite with a method to import essential fatty acids/lipids during rapid growth phases of sporozoites [1].	25.00	25.00	118.90	118.00	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-3.86	2	9	2009-01-15 18:05:59	2008-09-04 16:22:46	3	2	8	6	6	11	0	97.60	57	46.07	CHANGED	INKlNlpt.lhENpNslDlslKRaN.FhD.s+LuhQ+HFpcLSN-Q+c.hlNsh-YhpKhVQsLpEsRslslSKhQEshAVhslcaaLpc.Y.....Qpc.	INKVNlKG.LhENsN-lDVPlKRFNhFhDNs+LAhQHHFscLSN-QpcYhlNDhDYlRKlVQoL-EsRNlslS+hQEDhAVLslEaFLpc.Ytp............	0	1	2	5
+11400	PF11568	Med29		Mediator complex subunit 29	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-active part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Med29, along with Med11 and Med28, in mammals, is part of the core head-region of the complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein, which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators [4].	25.00	25.00	27.50	27.10	24.50	23.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.99	0.71	-4.15	7	108	2009-01-15 18:05:59	2008-09-04 16:40:37	3	2	83	0	61	99	0	135.60	45	69.25	CHANGED	p-ch....Dsls+VKsLl.ssLR-Sl.phhKpuAphLpQNp..Ds...pptpst-ssh.RF-KsLE-FaAlCDQlElsL+TAhpChpQtss........Ss+alPs.Vhss.....spsssh..sslsYspYLssVpspIppAKDIHcsLlssupplsst...........-	..............................................pch....Dslp+hKhLl.s.L+ESLp...shhKsAApsLhQNsslDNG.....tKuuD.s.slp........RFDKsLEEFYAlCDQlE.....LsL...+hAhECLo.Qsss........Ss+a.Ps.Vsss.....spsssspsssLsYsQYLssl+uQIssAKDIHssLlssupplssp......................................	0	19	24	45
+11401	PF11569	Homez		Homeodomain leucine-zipper encoding, Homez	Pollington J	anon	pdb_2ys9	Family	Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus [1]. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerisation and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain [1]. Homez is involved in a complex regulatory network [1].	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.89	0.72	-4.91	9	166	2012-10-04 14:01:12	2008-09-04 16:47:08	3	12	50	1	72	289	0	52.90	41	7.20	CHANGED	sh.ssscsl....Lp-YYhpH+hLpEpDLDsLspKSpMShpQV+-WFAp+.pcpscs	.....................h...sspth.....LccYY.h.p.H.+...h...L...pE.pDLspLss+SpMShpQV+-WFup+..c.s..t..........	0	6	10	31
+11402	PF11570	E2R135		Coiled-coil receptor-binding R-domain of colicin E2	Pollington J	anon	pdb_2ysu	Family	E2 is a DNase which utilises the outer membrane receptor BtuB to bind to and enter the cell. This family of proteins is E2R135 (residues 321-443) which is the part of E2 which is responsible for binding to BtuB in a coiled coil formation [1].	22.80	22.80	23.00	23.30	21.90	22.70	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.88	0.71	-4.07	2	37	2009-12-15 10:45:41	2008-09-04 17:03:58	3	11	21	6	3	46	1	126.60	56	19.71	CHANGED	HP.EuhcRpY-+A+AELsttscslAp.ppR.Aps.pshsut+utlptAsKplt-..AEhpp.DhhsasP.tthtphWQ....psphhppDlpNpptthcAAtpphs-hs.......AALSuA.EpRKQKEpKtKDAcsKLs	...............HP.EuhcRsY-+A+AELspAsc-lApsQpRpApAlps.......hsuR+SELDtAsKslt-h.AElKph-RFA+-PMAuGHRMWQMAGLKAQRAQTDVNNKpAAFDAAAKEKuDAD.......AALSuA.EpRKQKEsKc+DAcsKLs.......................	1	1	1	2
+11403	PF11571	Med27		Mediator complex subunit 27	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. The ubiquitous expression of Med27 mRNA suggests a universal requirement for Med27 in transcriptional initiation. Loss of Crsp34/Med27 decreases amacrine cell number, but increases the number of rod photoreceptor cells [4].	25.00	25.00	25.70	26.20	22.90	24.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.38	0.72	-3.86	18	176	2009-01-15 18:05:59	2008-09-04 17:06:26	3	3	146	0	120	170	0	91.90	36	25.59	CHANGED	shpths.apsSc............hplapclospsppAlhphhs.sp.tthsltphhsaIpSY...pslFssPCs+Cs+hl.....ptt.LP.....PshR..shss........h-saHpsCh	........................ts..thshastSp............apVFp+lo-+ApsAl.laah.....sphPc...hs.....l+shhsWlpSY...hpLFpsPCp+CG+hL......pstLP.....PsaR..chpo................................hEAaHpsCp................................	0	38	55	93
+11404	PF11572	DUF3234		Protein of unknown function (DUF3234)	Pollington J	anon	pdb_2z0r	Family	This bacterial family of proteins has no known function. Some members in this family of proteins are annotated as TTHA0547 however this cannot be confirmed.	20.20	20.20	22.30	45.80	19.40	18.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.39	0.72	-3.90	2	11	2009-01-15 18:05:59	2008-09-04 17:08:03	3	1	11	12	5	9	0	103.50	64	98.53	CHANGED	MAPDLSGTWYVLEGDPGEHLVVEALGERLSGIWTSRELAEAFLAHHPHLGMRVSALESRALKEAaLRALGMLQVEAVMVDYRPGTHRAQVARVKDLLEEVRRA	.....MtPDL.SGTWYVLEG..-..PGEHLVlEALGpRLSGIWTScELAcuFLA+.HPc.L.GMRVSsLESRALKEAFLRALGMLpVEAVhVDYRPGoHRAplARVc-LLEEVRRA.........	0	1	3	5
+11405	PF11573	Med23		Mediator complex subunit 23	Coggill P	anon	manual 	Family	Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice.	20.60	20.60	28.40	20.80	18.80	20.00	hmmbuild  -o /dev/null HMM SEED	1341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.02	0.69	-14.13	0.69	-7.23	7	204	2009-01-15 18:05:59	2008-09-04 17:13:51	3	8	102	0	133	209	1	793.90	37	84.96	CHANGED	Ms........ppllch.-p..........hlcsp..p....s......ps.psphtphst.....hsshhuthtpcp+pphl+.hlhhltthsp.p.........phchhhp.Lhchsttthl.uphLCtphh..pp..h.ppphh.Epa+hl+csIstlDYKGlRpIh+hhhE.phhphP.slSsphlsplhtlp-ll.+Ih-RsusLLPAYhslsEIh+shshps.h...W+Lsphlush.pcFRslAphhoIhG+sshLPIVpHs.....uatsthhs.Wclc.sshph.hpup..LPYcP-h.hpsQhhLLpaVLcQPYS+DMlsshhshp.pp+pppsshEp.LshllhpAMEpoEspspp.................pstspalW.HLos.lIYhlhapasshtshlpsL......+pKlstpplpRuRDclMWllLQalSuuhphstIss.hh.lhcLas.LYs-c..psl.lP-.sssphs+thAssClWhHL.KcAtscp.phscsIPpsLKhpaEhLpp.....ss.sh..ts-aplAlLsNAYSTsschFspsMssLh-sl.usscssps......uh.h.As.shsshshphLDuLTh+uKhSLl+pIlshhhp.upsKtssP....husALlETYsRhLVYpElESLuh+uhhuphh.......P.....pshpspAhs.LahLhEhhuYRhHHlpsah+hQh.....LoahpsLsulspssphQlapslEsssLRLI.............ptlGSsphpsp.shhlpc.c.PtslsSs........sEELN+sLIholARuh+lT....stss.upshsc-hLtsIhphTPasWsp+oLppFP.shp-hhpQpshsp.tsp.t.hhos--EhtphsoMpsEN-lIt+Fups...sssPlFLCllFKhl..h....pTpsIoshhYclLE+hus+slssplRphsDallhElusotsst.plpKsl.cslspMlW+aNllshDRllLsLhhRst-us-AQlsh.IhQLLLLp......ss-FppRlp.Fhpp.ss.-HappssahctHlsaHppFPEph.h-tssppsp.........LPlYFGNVChRhLPVlDlhlHRaLEh..hplsp....LtslLDplu.LYKFHcpPITalYsTLahacthhps+s..KKpLVsslhuplc-sRP..WsLoEtYpta.hppppsp..W.P-.sYahpLlcRhssolDuhs.....sFsupDWRasEFsNPsApALYloClELhuLPsuPptVsNulIsVllps.sllP.t.l.sahNslGLlhsALPpsYhssla-chhpslsssphtshp..h..sF-.FsFcshcpuhL-....pshssllslupuhapHhulupLsshscphh.plh.hV+TEhpLlYlh+lVGPaLpRh..........hpptcshuslslhhh.h.c.sshsp.uh.l.Y.s.lCDhhYphKYhFsG	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................W..h.s.hh.h.hh.t..hs..phh..l.......thh................p.p.lhWhhhphht....h.....................................h..sp.t..........h..h...s.....h.....h...t........................................................t..................t...hhhh....p.........h.hh.p...h..........................h.shshthls.....shohp.p..h...h.......h..........t...s............s.thh.Thsh.hhh.....phh.+.hhsth...............h.p.t...t..hhlhEhhsaRh...........h.....+.ph......L.h..hp.h..s..h...s..p.ht.p.pl.hhhEshshpLh.......................shhss.h...ts....hh.p...stthhp..................pLNRhhlholAhsh+hp.........t......hh..phLtplht.o...at....Ws.pohthFP..h..pt.hh..t...........p..........s................hts..p..p.hh.p.h.................tt.thl.pa.......................hLChhhhhh..h....p........s.....h.h..phl......pt..........hssptls.tl.hhsDhll.....ch....t.........t.t.........h....psh....t....ls.hlaphpllshDhhlLsLh.+s..cs..............ps.h...lhp..llp.......s-h.p.Rlp.ahp...s.cc...a......h.s..ph.pp..th.t..s-....p...t................................................................hPhaasslshRhLPlhslhlaRhlE.....h.p.......lLthhu.hhta.H.s..hoalhshL.hha...h...th..............Ll.thh.s.hp...p........hop.a.......t..........................pahhtLl.th............................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	62	75	111
+11406	PF11574	DUF3235		Protein of unknown function (DUF3235)	Pollington J	anon	pdb_3b4q	Family	Some members in this family of proteins with unknown function are annotated as RpfA however this cannot be confirmed.	21.10	21.10	21.90	22.10	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.28	0.72	-3.75	4	59	2009-01-15 18:05:59	2008-09-05 09:48:56	3	1	57	2	13	35	0	89.20	47	42.43	CHANGED	GLNSAPTPRslsAsst.PtPAsAAPA.stEYsAssshNoN.l.......sVcuhYsAlsspLAphGlsVPsElpuaYNA..................hlu	GLNSAPTPRDss.Ass..PA.......Ps.pssss..sQphA.Asuu.su-cL...........................AVDAlYsAlcsRLA...uhGluVPsplcuaYpAN+s.sFsuFYtANRtsIDhhh.h..................	0	2	8	13
+11407	PF11575	FhuF_C		FhuF 2Fe-2S C-terminal domain	Moxon SJ, Bateman A	anon	Pfam-B_11690 (release 9.0)	Domain	This family consists of several bacterial ferric iron reductase protein (FhuF) sequences.\	     FhuF is involved in the reduction of ferric iron in cytoplasmic ferrioxamine B [1].  This domain is the C-terminal domain that contains 4 conserved cysteine residues that are found to be part of a 2Fe-2S cluster [1].	20.50	20.50	20.50	20.60	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.89	0.72	-7.19	0.72	-4.27	60	1049	2009-01-15 18:05:59	2008-09-05 10:52:59	3	4	988	0	178	640	12	22.30	54	8.86	CHANGED	RcsCClhYpl..sus.ph..Css.CP..hh	..RRoCC.cY+l....Pss..pp......CGD.CsLh....	0	35	93	140
+11408	PF11576	DUF3236		Protein of unknown function (DUF3236)	Pollington J	anon	pdb_3brc	Family	This family of proteins with unknown function appears to be restricted to Methanobacteria.	25.00	25.00	121.40	120.20	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.79	0.71	-4.81	7	27	2009-01-15 18:05:59	2008-09-05 11:05:31	3	2	27	2	19	28	0	154.70	53	91.72	CHANGED	lE-hIppAahEShpstRhGDctEElctIpphIpsA++lVVsspNpcKhcVlpcllpchs.scsphLpIsTN.ADLTRhPAloKuLhAlDlocADllIARGRLGlPGSGShLlIMDp+GRlLTuuhSPSplIHppslc-ulppEhpcALpRIGhp	..hEchIKpAYhESlpspRhGD+hEElctIpphIhsAK+IVVsTpNpKKFcVlp-llpcl..........s.......splphLpIsTN.ADLTRMPAlsKuLhAlDhscADLlIARGRLGlPGSGShLlIMDsKGRILTuulSPSplIHKpslEcsVcpEhhcALcRIGl..	0	4	9	15
+11409	PF11577	NEMO		NF-kappa-B essential modulator NEMO	Pollington J	anon	pdb_3brt	Family	NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which results in the release of NF-kappaB which initiates the inflammatory response, cell proliferation or cell differentiation [1]. NEMO activates the IKK complex's activity by associating with the unphosphorylated IKK kinase C termini.The core domain of NEMO is a dimer which binds to two fragments of IKK [1].	21.00	21.00	21.00	23.10	19.90	20.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.28	0.72	-4.22	9	160	2009-01-15 18:05:59	2008-09-05 11:12:20	3	2	60	4	67	138	0	66.90	46	14.09	CHANGED	.tpslpphpcLlpENppL+EAlKQoNptMK-RaEELttWpE+Q+EER-Flpp+hcEA+phlptLshEN	......pth.pphpchLpENppL+...-Al+QsNQhh+cRhEEL.taptpQ+EE+-Fh.p+FpEA+chlppLohEp....................	0	9	17	37
+11410	PF11578	DUF3237		Protein of unknown function (DUF3237)	Pollington J	anon	pdb_3c5o	Family	This family of proteins has no known function	21.60	21.60	22.10	22.20	20.70	19.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.79	0.71	-4.91	66	476	2009-01-15 18:05:59	2008-09-05 11:23:30	3	11	281	12	270	484	95	145.20	24	71.09	CHANGED	PsL..chhasl........pl.......clsssh.....slGp..................sstG........pRpl.lsls..GGphpGs......plp.......................GplLs.sGuDathlp.s-G...........................hscl-sRasl..cTc..........DG......shIalpspGhhpss......thhp.thtt...upslss......s.phah................+ss.pFETu.s.s+Y.pWLsptlhVG....pupptss.t.....VhhcsapV	...........................................PtLphhhph........pl.........pl...ss.sh.....tlGp...............................ss.t.G........pRph..lslh....GGphpG..........tlp.....................................G..plls...sGuDath...hp..sss............................hscl.cs+Yhl....pTs................DG.....shIhlpspGhhp.ss...t.hht..htt.......spshs.................s..phhh..................pss...pF..ETu..s...tcY.paL.sp.tlalG..puphh.ss..t.....Vhhchap...........................................	0	46	135	217
+11411	PF11579	DUF3238		Protein of unknown function (DUF3238)	Pollington J	anon	pdb_3c5p	Family	This family of proteins with unknown function appears to be restricted to Bacillus cereus.	19.80	19.80	20.00	19.90	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.29	0.71	-4.67	2	116	2009-01-15 18:05:59	2008-09-05 11:29:37	3	2	59	6	10	87	1	181.60	58	86.79	CHANGED	MspIVKlRuSVFhPhuhhEPhKDstTG+lhpatGDuREFTPaAsNshRSRlEQEVslDFYKcElFoYAsssIsT.KlTNPDGSsphppGchSTENIVCTsIsWspDtVpFcMpASASNPLNshAPssDYLLslpVNKsGolclpG.HDGFPCaEFYKQVDFGsFEpIYhHDFRETsDTPtALuGEM-YSFpppl	..................................MspIVKlRuSVFhPhuhh.....E.shKD.t.TGplhpatGDuREFTPaAVNo..hRSRlEQEVllDFYKcElFoYAsssIs..T.KlT......N....P.DGSlphcpGcs.STE.N.IVCTsIlW.ss-.tVpFcMpASASNP.....LNshA.PssDYlLslpV.p+s.GolclpG.HDGFPCaEFYKQVD..FGs.FEpIYTHDFRETsDTsAALuG-M-YSFpppl.........................	1	1	7	7
+11412	PF11580	DUF3239		Protein of unknown function (DUF3239)	Pollington J	anon	pdb_3c8i	Family	This bacterial family of proteins may be membrane proteins however this cannot be confirmed. Currently there is no known function.	25.00	25.00	25.30	27.10	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.57	0.71	-4.11	7	82	2009-01-15 18:05:59	2008-09-05 11:49:43	3	3	81	2	19	66	0	124.90	42	54.56	CHANGED	P+phGshppLYsphpLsPAlluElsPRslVLLuLVsssssssspspaALssRslsplsGhs...++lGpRVPuVAlp....utcshcst-pW-plSPMPIsWGTsDssVlcRAEpsIsps.WspLppslspl-c	......P+pVGsAppLYssYsLsPAhIAEVNPRDhVlhALVNsssD.spss.P.....paALssRsloslsGhc...RpVGpRlPsVAVs....Gppospsp-pWppISPMPIuWuTsDssVlp+AtcsIPpcpWphLp+sls+l-.p...	0	3	13	18
+11413	PF11581	Argos		Antagonist of EGFR signalling, Argos	Pollington J	anon	pdb_3c9a	Family	Argos is a natural secreted antagonist of EGFR signalling which functions by binding growth factor ligands that activate EGFR by forming a clamp like structure using three disulphide-bonded beta-sheet domains [1].	25.00	25.00	28.00	26.70	18.80	23.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.92	0.71	-4.19	3	39	2009-01-15 18:05:59	2008-09-05 12:56:11	3	2	23	8	25	50	0	93.60	46	41.30	CHANGED	HSlKDlRILYQVGsSEcDLPV...........................CAPNAV.....................CSKI....................DLYETPWIERQCRCPcuNRsP.plIlHHHc+ssuo	......................................................................................................Cp.asVpp+..-.hh-ps.Ipp.CpCPcuaRCP......pHHopsu.........	0	7	8	19
+11414	PF11582	DUF3240		Protein of unknown function (DUF3240)	Pollington J	anon	pdb_3ce8	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.13	0.72	-4.07	11	148	2012-10-01 21:59:08	2008-09-05 13:09:45	3	2	146	1	47	234	49	95.10	29	92.06	CHANGED	hopphh.LsLlhs+-l+s-LsDhLhph.DhlSGFTlhcssGaupchphhshuEpV+GttctltlpllhsppshpplLspL+pthscssltYWltPVtshGpls	...............................h.....h.LplhhshsL+DsllDh.Lh.cp..s.h.ssFhhhpshuaus..p...p...h...h....hS.......pE.QVpG+...p......chsphclhlscptstsLlpsLcpph..sspth...hah...........t....................	0	10	34	40
+11415	PF11583	AurF		P-aminobenzoate N-oxygenase AurF	Pollington J	anon	pdb_3chh	Family	AurF is a metalloenzyme which is involved in the biosynthesis of antibiotic aureothin by catalysing the formation of p-nitrobenzoic acid from p-aminobenzoic acid. AurF is a non-heme di-iron monooxygenase which creates nitroarenes via the sequential oxidation of aminoarenes [1].	25.30	25.30	25.30	25.30	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.88	0.70	-5.50	33	580	2009-01-15 18:05:59	2008-09-05 14:47:50	3	1	308	10	194	533	184	282.80	21	88.21	CHANGED	M...........................spppshppLhcu.sc+uh...cPh....p..........sss+ahhPsphssLhssshapphspppphclsppchhshhssslhFEshlh....ptlh+shhstsssssptphshptlsDEshHslMahchhppls............ss.hphpRhhphlhphhsshh.pshstahsshluEphlssh.+shhcDsp.lpPhl+plhplHlh-EuRHhpFuc-hh+phhsph..sttpRthhushlshshthahss.lp.thhtts......slcstcultpsh..sssptt.phh+shhuslhphhccsGlh	........................................................................................................phhtpL.cu.usp.csh...sPhh.-lDWpss..........sssphhhssph.s...Lhs.pshapphsccp+hclspachushhshslahEp.h.Lh....phlhpphht.t.s...s.s.s.s.php.a.sh.s.p.hsDEspHshMFtch.l.p.+hs................sshhth..chhp..h.l..ht.h.............h.s..s......sh..hs......hshass....h.ll...uE-h.ls...ph...p..+...ph....hc....Dsp..l.pPhh+plhplHlh-EARHluFu+....chl....ccth.sph......sphpRt....h.hphh...hsh.sht.hh.hps.h..hs.st.hhhhh......shs..cshtpth...tssp.p..phhpt.hhtplh.hhcchGlh..................................................................	0	49	126	168
+11416	PF11584	Toxin_ToxA		Proteinaceous host-selective toxin ToxA	Pollington J	anon	pdb_1zld	Family	ToxA is produced by particular Pyrenophora tritici-repentis races and is a proteinaceous host-selective toxin. It is necessary and sufficient to cause cell death in sensitive wheat cultivars [1].ToxA adopts a single-domain, beta-sandwich fold which has novel topology. The protein is directly involved in recognition events required for ToxA action. It is thought to be distantly related to FnIII proteins, gaining entry to the host via an integrin-like receptor [1].	25.00	25.00	25.10	256.70	18.40	17.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.72	0.71	-4.25	2	16	2009-01-15 18:05:59	2008-09-05 16:00:25	3	1	6	4	2	14	0	117.80	97	67.67	CHANGED	QGSCMSITINPSRPSVNNIGQVDIDSVILGRPGAIGSWELNNFITIGLNRVNAsTVRVNIpNTGRTNRLIITQW-NTlTRGDVYELFGDYALIQGRGSFCLNIRSDoGRENWRMQLEN	QGSCMSITINPSRPSVNNIGQVDIDSVILGRPGAIGSWELNNFITIGLNRVNANTVRVNINNTGRTNRLIITQW-NTLTRGDVYELFGDYALIQGRGSFCLNIRSDSGRENWRMQLEN	0	1	1	2
+11417	PF11585	Stomoxyn		Insect antimicrobial peptide, stomoxyn	Pollington J	anon	pdb_1zrx	Family	Stomoxyn, localised in the gut epithelium, is an insect antimicrobial peptide which functions in killing a range of microorganisms, parasites and some viruses. Stomoxyn has a structure consisting of a random coil in water however in TFE it adopts a stable helical structure. Stomoxyn is thought to have a similar function to cecropin A from Hyalophora cecropia due to structural similarities [1].	25.00	25.00	26.20	102.30	23.30	18.70	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-8.13	0.72	-4.16	2	2	2009-01-15 18:05:59	2008-09-05 16:08:59	3	1	1	1	0	3	0	42.00	81	62.69	CHANGED	RuFRK+FN+hlKKlKHTISETAHVAKDsAVIAGSGAAVVAAs	RuFRK+FN+hlKKlKHTISETAHVAKDsAVIAGSGAAVVAAs	0	0	0	0
+11418	PF11586	DUF3242		Protein of unknown function (DUF3242)  	Pollington J	anon	pdb_1vr8	Family	This protein from Thermotoga maritima is a hypothetical ORFan protein, TM1622, whose structure has been determined. The protein is composed of seven beta strands and three alpha helices [1].	25.00	25.00	134.20	134.00	22.70	20.60	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.81	0.71	-4.60	4	11	2009-01-15 18:05:59	2008-09-05 16:31:12	3	1	11	1	5	12	0	129.20	42	81.71	CHANGED	PpuYSlcoAlhlLps.pYhLssVtcl.-uYGsl..ucGhsA..lF-shsGhFalFKYhsEp.AKp.WKKlsKchGhs.phsYh..shhshGhFos+h-upcIlsWWKDNWLFllpGcs.s--FspaV.clYtclK	PcuYSl-oAIhlL-s.cYhLsDlcEI.DuYGDV.phKG+VA..lF-scpG.hlalatYcuE-.AKphWKKlsK+hGhsShRohL..-LsshGhFSThh-GKcIluWWKcNWLFllEG+sslE-FVcaVhcVYpclK.	0	2	3	5
+11419	PF11587	Prion_bPrPp		Major prion protein bPrPp - N terminal	Pollington J	anon	pdb_1skh	Family	This family represents the N-terminal domain (1-30) of the bovine prion protein (bPrPp). The proteins structure consists of mainly alpha helices. BPrPp forms a stable helix which inserts in a transmembrane location in the bilayer, with the N -terminal (1-30) functioning as a cell-penetrating peptide [1].	20.80	20.80	20.80	21.60	19.00	20.10	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.96	0.72	-7.02	0.72	-4.28	8	461	2009-01-15 18:05:59	2008-09-05 16:47:14	3	6	190	1	19	408	0	28.10	83	11.54	CHANGED	Mu+..luCWlLVLFVAsWSDVGLCKK.PKP	..MVKSHlGuWILVLFVAhWSDVGLCKKRPKP.	0	1	1	4
+11420	PF11588	DUF3243		Protein of unknown function (DUF3243)	Pollington J	anon	pdb_3d0w	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	20.00	20.00	20.00	21.90	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.58	0.72	-3.99	17	247	2009-01-15 18:05:59	2008-09-05 16:59:24	3	1	189	4	63	156	0	80.70	49	91.39	CHANGED	MslL-s.a-pWKsaLucplppupptGhsccslschAhplG-YLAppV-PpNpcE+lLp-LWcVAs--Ep+sLAshhVKlVpp	...........................MoVL-N.FDpWKsFLG-RlcpApptGLsptsluchAaclGD.YLAscVEs+NcpE+LLtELWcVADEpEQHsIAslMVKhVpp....	1	25	49	53
+11421	PF11589	DUF3244		Domain of unknown function (DUF3244)	Pollington J	anon	pdb_3d33	Domain	This domain adopts an immunoglobulin-like beta-sandwich fold  and structurally is most similar to fibronectin.	22.00	22.00	22.00	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.26	0.72	-4.33	10	185	2010-07-04 00:38:26	2008-09-05 17:09:39	3	9	75	3	38	154	25	101.30	21	65.17	CHANGED	s.ohpphs+......slshcGcW....t-cttRSI.sslP.oASI..DGslLsIcFpsslsslTIslpc.ppGsVlYEsslssusuptholSlsshssGcYplclopstG.aLhGpFhlE	..................................t......................h.....t..t....RSl....hPhp.s...l...-..s..s..h..l.pl.pF.t.p.shss.l.s....lplps...psGpll.Ypsshss.s.ss.t.h.sIsL.ssh.s.sGpYpLplpssps.hh..hGpFp...............	0	18	33	37
+11422	PF11590	DNAPolymera_Pol		DNA polymerase catalytic subunit Pol	Pollington J	anon	pdb_1dml	Family	This family of proteins represents the catalytic subunit, Pol, of the Herpes simplex virus DNA polymerase. Pol binds UL42, making up the DNA polymerase. UL42 is a processivity subunit which binds to the C-terminal of Pol in a similar way that the cell cycle regulator p21 binds to PCNA [1].	20.00	20.00	21.90	34.10	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.79	0.72	-4.28	8	108	2009-01-15 18:05:59	2008-09-08 09:10:44	3	2	21	4	0	170	0	36.70	78	3.03	CHANGED	c-sAtRLsuAGFsslpuGA....spEEETRQ+L++AFcILA	.DDVAARLRAAGFGslGAGA.....TAEETRRMLHRAFDTLA	0	0	0	0
+11423	PF11591	2Fe-2S_Ferredox		Ferredoxin chloroplastic transit peptide	Pollington J	anon	pdb_1fct	Family	The structure of chloroplast ferredoxin in water is unstructured however in a 30:70 molar-ratio mixture of 2,2,2-trifluoroethanol, residues 3 to 13 form an alpha-helix. The rest of the peptide remains unstructured [1]. This family is the N-terminal of the [2Fe-2S) ferredoxin from C.reinhardtii. This protein catalyses the final reaction in a pathway which allows the production of H(2) from water in the chloroplast [2]. 	25.00	25.00	62.90	62.20	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.64	0.72	-4.31	2	6	2009-01-15 18:05:59	2008-09-08 09:34:00	3	1	4	1	3	4	0	33.00	80	25.98	CHANGED	MuMAhRSoFAARV.GA+PAVRuARPuuR.hSs.A	MAMAMRSoFAARV.GA+PAVRuARPuuR.hSs.A	0	1	3	3
+11424	PF11592	AvrPto		Central core of the bacterial effector protein AvrPto	Pollington J	anon	pdb_1r5e	Family	This family of proteins represents the bacterial effector protein AvrPto from Pseudomonas syringae. This is the central core region of the protein which consists of a three-helix bundle motif. AvrPto is part of a type III secretion system from P.syringae which is involved in the bacterial speck disease of tomato. In resistant plants, AvrPto interacts with the host Pto kinase, which elicits an antibacterial defense response. In plants lacking resistance, the Pto kinase is not present and AvrPto acts as a virulence factor, promoting bacterial growth [1].	21.80	21.80	24.10	61.20	20.40	15.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.24	0.72	-4.26	2	21	2009-01-15 18:05:59	2008-09-08 09:57:52	3	1	19	2	2	19	0	105.30	53	65.34	CHANGED	DNVTSsQLLSVR+QLAESAGLPRDQHEFlSSQAPpSLRspYNNLYSHTQRTLDhADMQHRaMTGASGINPGMLP+ENVDDMRSAIoDWSDMREALQHAMGIHADI	.....s.sVTusQLLsVRHQLA-uAGLPR-QHcFIoNp.APpoLRsRaNsLYs+TQRTLchADhQHRYMTGsSulNPGMhPHENVssMRoslScWSDMREALQHAMslHssh...	0	0	0	1
+11425	PF11593	Med3		Mediator complex subunit 3 fungal	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [1]. Mediator subunit Hrs1/Med3 is a physical target for Cyc8-Tup1, a yeast transcriptional co-repressor [2].	27.60	27.60	27.70	27.70	27.20	27.50	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.49	0.70	-5.22	5	30	2009-01-15 18:05:59	2008-09-08 10:35:47	3	3	26	0	19	34	0	319.90	39	85.24	CHANGED	DsILsssloL--Lc-hLu.csEu.o+DsVsc+IpcA+DuILPLRLQFNEFlpllSsI..EchuspTsQEKFLhIRSKLL-Lpc+lQsLSpDFcpLQPLFsTVsEYScTh..+-KKFQlLETL.............................GoYscsussuASsShspsSs+SsAATTuSTAsTPuA..AslssApoAus.........PssTssl.............Gos.ssss.h.soTsssshstsKKPRKPRQTKK.....sAsAAKsQ..............ASAsAsAsAuA.sp............................................ssh.tss.NuuMtsslPN...sTPs.Mt.....lsusSP.........s...............NuMuSPL......NsMSPMpNhsQ....MGt.s.h...GQhs.sss.GstsspsspsshpussTPStSM...hN.NNITPANILNMS.........s.uF-p.sQsQsPQQttsQsQ.pshNMsM.sDsNN....hD.lDLNNLDLuSLNMDFL	....................................spllssslpL--LpshLA.p..........s-s.s+DpVsppIpcsccpILPLRLpFN-FlphMusI.......-t.ppssp.tKaLhIRsKlLpLss+hQsLSpchptLQPLFsTlsEY.coh..ps+pFp.LEsL.............................uohscsusAssSsu...tshsos+SsAAo.TsoTssTPtA....sshsp..upohss.........Psoossh.............uos.sTss.stsoTs.ssshsssKKPRKPRpTKK..............ApsQ......................spApApApAQs.tpp......................................ss..psshsuuMsuslPN...sTPs.M........lNusSP..........p..............NsMuo.PL......NhMSPMsNs.p....hGt.s.t...uphp..t...us.hss.s..sshpts.ss.ps....hs.NslTPANILsMs.............................shpp.pQ............p...p...th...s.Ns.......lDLNsL-LuuLNMDFL.........................................................	0	2	7	16
+11426	PF11594	Med28		Mediator complex subunit 28	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours [4].	23.40	23.40	23.40	26.50	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.50	0.72	-3.80	3	97	2009-01-15 18:05:59	2008-09-08 11:35:36	3	1	79	0	66	90	0	102.40	48	51.22	CHANGED	EIRstVDQsopKF..LDIARQpEsFFLQKRhpL..SVhKP-plLKEEsp-LK...pEl..........QRKDpLl.............pKHhoKI-aWcNL...LoDtpshaKshs-lPs-GRtslsE.uo...............uslPus.c	..........EI+stV-Qshp+F..LDlARQhEsFFLQKRhpL..Ss.KPEpllKEDlsEL+...sEL.........................QRK-sLl....................QKHhsKLcpWQpl...LpDlpsttc..tp..h...h..t..............................h...................................	0	17	22	45
+11427	PF11595	DUF3245		Protein of unknown function (DUF3245)	Wood V, Coggill P	anon	Chahwan C	Family	This is a family of proteins conserved in fungi. The function is not known, and there is no S. cerevisiae member.	26.40	26.40	26.60	27.20	26.10	26.30	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.03	0.71	-3.93	12	68	2009-09-11 06:21:26	2008-09-08 13:01:24	3	3	59	0	51	64	0	134.70	31	67.63	CHANGED	KssVuLu+oQ+LluSWLss.osstpups.ps-pELQp...c.hpsVPppLGlGAslPppuscu..o.pp.cLsS.....sDcL++QLLGKshp+hhutttt.....s.s..pppuss.ssptsspsstht--sD-DD--.EuRouhhu+pt...........+KR+	........................tsVuLu+up+LluSWlsshossc.tsss.csEpEhp...tthh..ps.hPc+LGLGAs.lPppttcu....s..t...tS.....sDcLc+pLLGK.............................pppsst.tttppppst..sscps---DE-.EuRouhhu+pp....................t...........................................................................	0	13	25	40
+11428	PF11596	DUF3246		Protein of unknown function (DUF3246)	Wood V, Coggill P	anon	Chahwan C	Family	This is a small family of fungal proteins one of whose members, Swiss:A3LUS4 from Pichia stipitis is described as being an extremely serine rich protein-mucin-like protein.	27.80	27.80	96.00	30.60	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.24	0.70	-5.08	5	14	2009-09-10 21:41:12	2008-09-08 14:01:14	3	3	10	0	9	15	0	190.90	37	28.88	CHANGED	DDDDDETDC--..ET.............llPTsosslTTlsGoGuVTlTsGGSGu..sshttou..........oILPTtoup.......DDDD..sD--TDsEssT.sh.ssGoVTpsPTGoTotTllsoc...uTTssDDDDssssEooIs..DsTssTssT.hTssGsPTs.TVTTNusATTTs+Tpscss.....lTYTuTGpspTTtsTp--ED...CDEThshThThhsPoTTVh.sstlhsNsVTVIupho.h.pshEsDutpssGSGSGSsGSGGS..GSGSS	..........................................s.h.s..s....h.h.sss...hssssto...........s.lsThssp..................ssD-...D-ETDCETsh.sh.PsGss........ThhsTsosohTllsTc...sTTos----psssEssh...psTs.sp.T.hT.sts.TT..lssphssssp.....chs.....lTYTusGpshTThhoppsE....C-EThhhThThhsPpTTVh.sstl.sssVTllsp.o.h.ps.psDsh.......pGpssuuuS..uSGuS.......	0	3	5	9
+11429	PF11597	Med13_N		Mediator complex subunit 13 N-terminal	Coggill P	anon	manual	Domain	Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood [4].	25.00	25.00	34.70	33.50	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	401	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.33	0.70	-5.79	18	237	2009-01-15 18:05:59	2008-09-09 14:16:19	3	6	144	0	154	218	0	328.70	28	18.84	CHANGED	Ms..st.......................sthoNhhsl........sthssIha+ha..............s...s.hhp.hp+h.phc.LplhhRp.ss...................................tthtLWlF.hssp.p.ht...............ptts.pstlshpstoLhhpA.tsl.tpsLhcs.hsphspttsss.sssp+s......ssssp+........................................hushashFlousosslot.hl+ppssI.LsoRohlshspp..........................................................phh.sPhslssshou.sh..Los........................................................................................................................................................hpsplsusGcLsVuhpshshPulhsLss.s-sst.h..h..tsslhhuPouuhuphhusssssssssssssssssttsssps...............sshpphphtshphLpthGhs.sss.pspsWlplpshpshhsplssphhptsppsppss....shchlhWPtphCF	.......................................................................................................................................splsuIpW+ha....t...................s..s..tsshh.u.h.cshps.phltshhRp.t........................................st+pLWlF....ah..s.p.-..ssh.t.ht.................pp..s.hp.st..lsh...ps.p.oL.lhcA.hts.lhp...+.s.Lhpc.shs+hGcahl..pP.hp..psc+.......hspSp+..................................................LSsuFsFFlHG-SsVCoSl-lppHpslhLlscpHlph..Apps............................................................tshpVhluPaGls.GsLTGpuh.chos....phhtc....................................................................................................................................................p....hc..ss..ssVcVlVu....u.s+hhaPuthlLl....stsD.s....................ssssuth.......u....t...h...s..spps..sus.psss.ps....s...hssss.s.t......................................p..ptpth.ph.s........t....tt...p...t.ts.....thh.hsht.C........................................................................................................	0	30	56	106
+11430	PF11598	COMP		Cartilage oligomeric matrix protein	Pollington J	anon	pdb_1fbm	Family	This family of proteins represents the five-stranded coiled-coil domain of cartilage oligomeric matrix protein (COMP). This region has a binding site between two internal rings formed by Leu37 and Thr40 [1]	20.80	20.80	20.90	21.10	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-8.27	0.72	-3.89	12	203	2009-01-15 18:05:59	2008-09-09 14:26:53	3	22	60	15	94	168	0	44.50	45	5.26	CHANGED	DhscpLl...spLpphsplltEL+-.l+p.......................Ql+EhshLRsTItcCpuCG	...........spthl...pplpphNplLsEl+-hlRp..................................................QVKEhoaLRNTIhECpuCG...	0	10	19	44
+11431	PF11599	AviRa		RRNA methyltransferase AviRa	Pollington J	anon	pdb_1o9g	Family	This family of proteins represents the methyltransferase AviRa from Streptomyces viridochromogenes. This protein mediates the resistance to the antibiotic avilamycin. AviRa methylates a specific guanine base within the peptidyl-transferase loop of the 23S ribosomal RNA [1].	26.10	26.10	26.60	132.50	24.60	26.00	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.73	0.70	-5.35	2	11	2012-10-10 17:06:42	2008-09-09 14:39:40	3	1	11	2	6	13	1	242.50	39	98.23	CHANGED	Mp.Y+a.scp.s.pDhAsGhVLapssG.PsFPVRLAhEIapRsLth..tcu.loLaDsCCGuuYhLolLGLL+ppoltplhuSDlsstslpLAscNLuLLo.uGlstRc.Eh+t..ppatKsSal-AhpuhcRlcEhLTtE.......I+Th.lFcspsLpss.hs.sPDlllTDlPYGphscWEt..sutslsthhpuLuushsucslIsV.hD+ppKI.ss.hptLER.hlGpRph.lh..+Au-lh	....p.Y+atosptsYpDhASG+VLasAsGhPuFPVRLASElhQRshphL.p...p...uPhTLaDPCCGuGYLLTVlGLLHscplpplluSDlsscsLplAt+NLuLLotpGLppRpcpL+chhcpasKPSah-AlcSAcRLcchlsts.ss.s.tshtpADlhcsps.tsh.stshss.cIVlTDLPYG-hosWpG...suss...PlsphLsultslL.P.spuVVsV.os+ucKlp.p.sch+tlc+lKlG+Rpssla..h.........	0	2	6	6
+11432	PF11600	CAF-1_p150		Chromatin assembly factor 1 complex p150 subunit, N-terminal	Pollington J	anon	pdb_1s4z	Family	CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesised and acetylated histones H3/H4 into chromatin during DNA replication and repair [1]. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesised and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis [2].	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.26	0.70	-4.96	13	305	2012-10-03 14:45:15	2008-09-09 14:49:06	3	48	200	0	206	304	4	187.60	19	26.44	CHANGED	ssEucshEsss-s-.SVLSpSSh.SShSso.SSPEussss.chpss..........sSPhsuSTslc+hopKpl+pptEKpKh+hp+....ttth..............hctE+pE+ccl+...pEtKtttc+tK......EEt++cKcEEK-l+E+ER..+E..KKE+-EKEKAEK.RlKEE+RKE+p..Es.t.....AKhEEKRK....KEEEKRL+EEc.......cRIKAE..KAEITRFFQKPK.TspAPK.........TLAuuCGKFAPFEIKEsMlL	..........................................................................................................ts........................................................t...............................ps.....ps.....hp.p.h..p..pp.hp...t.t..t...cp.p..p..p...pc............t.tt.........................pp.pc+p.c.c.c.ct+..ccp..+p.p.c....c....p..pK.......cpcccc..+.c.c....c+.c...tcc....cE.+......cc.....c+p..ccE.c-+..tc.....+pc.....+cccc.cc.cp...............t+..cp.cpt.......+ccp....cphtpct.............................ptp.....t.....h.t.h....................................................................................................................................................	0	66	109	166
+11433	PF11601	Shal-type		Shal-type voltage-gated potassium channels 	Pollington J	anon	pdb_1s6c	Family	This family of proteins represents Shal-type voltage-gated potassium channels which interact with Kv channel-interacting proteins to modulate cell surface expression and function of Kv4 channels. The interaction of the Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a structure which is like the structure between calmodulin and its target peptides when they interact. Interactions of an N terminal alpha helix in Kv4.2 and a C terminal alpha helix in KChIP1 are essential for the modulation of Kv4.2 by KChIPs [1].	20.50	20.50	22.60	22.10	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.43	0.72	-4.43	4	194	2009-01-15 18:05:59	2008-09-09 15:44:02	3	6	79	11	112	179	0	29.00	79	5.01	CHANGED	uuVAAWLPFARAAAIGWhPlAspPLP..P	...AGVAAW.LPFARAAAIGWhPlAssPMP.AP...	0	19	28	59
+11434	PF11602	NTPase_P4		ATPase P4 of dsRNA bacteriophage phi-12	Pollington J	anon	pdb_1w44	Family	P4 is a packaging motor which is involved in the packaging of phi-12 genome into preformed capsids using ATP. P4 is located at the vertices of the icosahedral capsid. ATP drives RNA translocation through cooperative conformational changes [1].	20.40	20.40	20.90	28.80	20.20	20.30	hmmbuild  -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.02	0.70	-5.44	3	7	2009-01-15 18:05:59	2008-09-09 16:09:10	3	1	5	60	0	10	1	299.70	30	90.31	CHANGED	s+LhDAKPsAl.+lApPAAlcTsussoah...AAVhE.Sl+DGGs.......LhAVGlc...PlVlDKDAtphlAsKtKSuDsESs..........uVshVsVpNssl+..........osPLLus+PVsu..usHRWsscshhSGlslVsGuTGSGKS.......csLNuK.cPDVTIRWGEPuEuYDp.DouVaVuDLsEMLhVslhLAsLsaRV.VIDSlRNLlFulsGAAouGGISsuhYuLLTDIuNlsAphGClVVAulNPMSsDDK.VELVassltASosGhllssDussVSQTlhRTGcGRIFsG.tPLsRsTHslphccPcHopLs-HTShuSsu+LESG....oVDsDDEN-SsPRRGA	..........................................................................................c.hDApshuh.hhut.sshpsss.ts.....uuVhc.u.cpGs........lhuls.......Vh.Kss..hht.t.huscs.ss..............V...sshhh..........ss.hluppPVs.....HRas.....SGlhslhGtssSGKo........tLstc.cs.shIRaGEshpuYsp.Dhsltlsslsc...sslhLu.shsapV.slDSlRsllhpltGsAouGGIstshauhLTDluslhsphsC.VVhslNPhsss-K....lE.hVatpshASssuhhlssDss...pshhRTscGhIhsu.tsLstssc..phphspphphh.+oo.susu.ltps....oV.ssDc..shsRRhs..................	0	0	0	0
+11435	PF11603	Sir1		Regulatory protein Sir1	Pollington J	anon	pdb_1z1a	Family	Sir1p interacts with the BAH domain of the Orc1p subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae [1]. The amino acids from the ORC interaction region of Sir1p are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing [1].	25.00	25.00	25.70	25.10	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.64	0.71	-3.99	2	55	2009-01-15 18:05:59	2008-09-09 16:23:57	3	3	21	4	21	61	0	126.40	31	27.48	CHANGED	h.p....lssRhhVhDGaLlDhsccKPIN.+sPclhhLL.pDcphthlsQ.NLVcWschKK.pss..lslKuhpLFKahK.lh+cFhhhtDh+lhhh.hcupL+Yc.sc+hT..CpCs.l.Lsc.ss.Ylas.	......hh........lSsRasVl.DGaLlDhsc......+Ks.IN.c...sPclhp....hL.sDc-tcplsphsLlDWschK...c.s...pss..lslcuppLFchlcthh+cFhpstD.G+l..hlhsscsph+hc..scchT..p+Ch.lhLschsshYla................................	0	2	12	19
+11436	PF11604	CusF_Ec		Copper binding periplasmic protein CusF	Pollington J	anon	pdb_1zeq	Family	CusF is a periplasmic protein involved in copper and silver resistance in Escherichia coil. CusF forms a five-stranded beta-barrel OB fold. Cu(I) binds to H36, M47 and M49 which are conserved residues in the protein [1].	20.50	20.50	20.50	20.50	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.30	0.72	-4.12	186	1350	2009-01-15 18:05:59	2008-09-09 16:47:19	3	19	804	6	364	993	141	68.20	33	32.48	CHANGED	Gplppl-.tssplTlpHuslss..lsh.P.uMTMsFs.ls...sss..lsslpsGspVcFphpp.ssss.hs..lsplp..p	.......GhVcslDhpspplTlpHsPIss.........ls...W..P.uMTM.sFs.ls...sss..thsplKsG-cVpFshhp.psst.hh..lpslp...s.............................	0	72	191	266
+11437	PF11605	Vps36_ESCRT-II		Vacuolar protein sorting protein 36 Vps36	Pollington J	anon	pdb_2cay	Family	Vps36 is a subunit of ESCRT-II, a protein involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late endosomes [1].	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.79	0.72	-4.17	22	246	2012-10-04 00:02:25	2008-09-09 17:02:47	3	7	224	4	174	261	0	86.50	33	17.27	CHANGED	phssSspPlLppsEp.lhlpcsVGLYpGcp..KhhsppsG+laLTo+RlIYsDstcspp.ulsltLphlpps....chsuuFh.ppSsKIhlhLcp	..................t.hpshL....sEshlhhp..csVsL.Y...-Gct..........Kh.............p.........apsGplhLToHRllah.Dpp.p...s....p..p.........s..lulsLppltph.........Eht.uuhl..tpSsKIhlalc...............................	0	52	88	142
+11438	PF11606	AlcCBM31		Family 31 carbohydrate binding protein	Pollington J	anon	pdb_2cov	Family	This family of proteins represents the family 31 carbohydrate-binding module of beta-1,2-xylanase. This protein is from Alcaligenes sp. strain XY-234. The AlcCBM31 module makes a beta-sandwich structure with an immunoglobulin fold and contains two intra-molecular disulfide bonds. AlcCBM31 shows affinity with only beta-1,3-xylan [1].	25.00	25.00	35.20	108.70	19.20	16.30	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.18	0.72	-4.02	3	5	2009-01-15 18:05:59	2008-09-10 10:58:01	3	2	3	6	0	6	0	92.00	48	19.81	CHANGED	EPPENCoDDFNFNYVSDsEIEVYHVDK.GWSAGWNYLCLDDYCLSGTKSNGAFoRoFSAsLGQTYKlTFKVEDhsGQGQQIlD+slTFTsQVCN	...psPEsCo-DFGaNYVSDoEIEVFHpDp.GWSAGWNYlCLDDYCLsGsKSNGuFsRoFsAsLGQTYKITFKVED..GpGQaIlDKslTFTNpsCs.	0	0	0	0
+11439	PF11607	DUF3247		Protein of unknown function (DUF3247)	Pollington JE	anon	pdb_2e12	Family	This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions [1].	25.00	25.00	66.70	66.40	21.00	20.00	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.17	0.72	-3.77	7	26	2009-09-10 23:21:42	2008-09-10 13:05:27	3	1	26	2	6	28	0	98.30	64	94.18	CHANGED	MPKYAPHVYoEQsQIATLEtWVsLLDGQERVRIELDDGSMIuGTVAVRPolQTYhDEpccEGsNGQLRLDpLDASQEPQWIWMDRIVAVHPhPLGA.PpVMP	...MsKaAP+VYoEQsQIATLEpWVsLLDGQERVRIELDDGSMIuGTVAVRPolQTYhD-pcsEGlNGQLRLDpLDASQEPQWIWMDRIVAVHPL.LGAsPpVMP......	0	1	3	4
+11440	PF11608	Limkain-b1		Limkain b1	Pollington J	anon	pdb_2diu	Family	This family of proteins represents Limkain b1, which is a novel human autoantigen, localised to a subset of ABCD3 and PXF marked peroxisomes. Limkain b1 may be a relatively common target of human autoantibodies reactive to cytoplasmic vesicle-like structures [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.92	0.72	-4.23	5	78	2012-10-02 20:46:34	2008-09-10 13:06:52	3	15	49	1	42	105	2	86.10	62	6.32	CHANGED	CpSLLaVaNLPsN+D...uKAIuNRLRRLSDNCGGKVLuISGsSAlLRFuNQEuAERApKRMENEDVFGNRIoVSaoPt.R-ss-scschp.ss	.........................CHTLLYVYNLPsN+D...uKSlSNRLRRL....SDN.C..GG.KV.L.....S....I......o...G..s.S...AILRFlNQ-SAERAQKRMENEDVFGNRIhVSF.o.P+s+Ehs-scsp....shs............	1	12	14	25
+11441	PF11609	DUF3248		Protein of unknown function (DUF3248)	Pollington JE	anon	pdb_2e6x	Family	This family of proteins is thought to be the product of the gene TT1592 from Thermus thermophilus however this cannot be confirmed. Currently there is no known function.	20.20	20.20	20.20	73.70	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.83	0.72	-4.27	2	19	2009-01-15 18:05:59	2008-09-10 13:13:55	3	1	19	4	13	17	0	63.20	63	84.51	CHANGED	L-tLGtpLVWRhG+sE.pDslVVRlGhASATPRFtcLPRLhshs-AEhpchsQpGRlhlEWV-	L-tLGpHLVWRIG+uEsE-l...LVVRVGLASATPRFtcLPRLhNlsDAElccLlpcGRVRVEWVE.	0	3	8	13
+11442	PF11610	Ste5		Scaffold protein Ste5-Fus5 binding region	Pollington J	anon	pdb_2f49	Family	This family of proteins represents the Fus5 binding region of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mitogen-activated protein kinase. Auto-activated Fus3 has a negative regulatory role, and promotes Ste5 phosphorylation which leads to a decrease in pathway transcriptional output [1].	20.60	20.60	21.60	68.50	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.06	0.72	-7.31	0.72	-4.42	2	10	2009-01-15 18:05:59	2008-09-10 13:47:16	3	1	9	0	1	10	0	30.00	98	3.34	CHANGED	TPVERQTIYSQAPSLNPNLILAAPPKERNQ	TPVERQTIYSQAPSLNPNLILAAPPKERNQ	0	1	1	1
+11443	PF11611	DUF4352	TRF2;	Domain of unknown function (DUF4352)	Pollington J	anon	pdb_3cfu	Family	Members of these family are poutative lipoproteins that fall into the Antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.52	0.71	-3.98	49	1093	2012-10-03 03:07:29	2008-09-10 15:00:56	3	22	747	2	203	850	26	123.50	19	50.75	CHANGED	hplu-ssp.h.sshplsVsss.....ths.s.sphhp............pssspalllslolcN.puccshshss..pFpLh.cspupphc.hshsspptt......s................h.hsslsPGppssGplsFclspssp....hpLpa.....ssh.asst......tl	...............................................................spssp.......s.s.h.cl.....olsss..........hs.s.sp..h.t..ps.....................pstspa...lhls..lsl.....c.N...puccsl..s...h....s...s...t...pa.pLh....s...sc.sp...p...a..c...hs.ssst.t......t................hhhpplsPspshpG.p.......l.sF.-l..sp...ssp.....hplph....ssh.......t..................................................................	0	69	147	184
+11444	PF11612	T2SJ	GspJ;	Type II secretion system (T2SS), protein J	Pollington J, Desvaux M	anon	pdb_3ci0	Family	The T2SJ proteins are pseudopilins, which are targeted to the membrane in E. Coli. T2SJ forms a complex with T2SI (Pfam:PF02501) and T2SK (Pfam:PF03934) which is part of the Type II secretion apparatus involved in the translocation of proteins across the outer membrane in E.coli. The T2SK-I-J complex has quasihelical characteristics [1].	20.40	20.40	20.40	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-11.27	0.71	-4.52	87	934	2009-09-11 07:38:19	2008-09-10 16:15:32	3	4	804	11	192	656	242	157.00	26	74.61	CHANGED	c-tspppspclppLQRuhshl-pDlpQh..................................ss....RssRst...Gt..sshhhtssp.................ltFsRsGWtNP.th............PRusLp+VsY..pl............p........ssp..LpRhhashhDs.stst.tPthp...slLss.........Vpshplca..h..........sss..............pWpcp...Wss.............sptLPpulclplphpsh....G.plpRhahlssts	..............................................................................................p..hsttcspclstlQpshshlppDlpQh..................................hs............R.sRss....ut..sthh.htss...h...t...............hltFsRtuhhNP..h..............sRusL.p.VsYcl.................c......................ssp.......Lp.R.hsa.s..hsDs....sss....pPthp............sLlst..................Vcuhplpa.....a.................................sss.........................pWppp.....Wss...........................sptlPh.AVclsLphpph....G.plpRhahl.t.s................................................	1	54	108	151
+11445	PF11613	UCN2		Agonist of corticotropin releasing factor R2, Urocortin-2	Pollington J	anon	pdb_2rmg	Family	This family of proteins represents urocortin 2, a member of the corticoliberin family which is a selective agnonist of corticotropin releasing factor 2. The backbone of the protein is mainly alpha-helical but it contains a helix-loop-helix motif [1].	22.00	22.00	40.90	40.50	20.70	20.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.74	0.72	-4.00	4	62	2009-01-15 18:05:59	2008-09-10 16:49:57	3	1	35	5	36	68	0	37.80	66	26.12	CHANGED	lsLSLDVPhslhplLh-.A+AKshRsQAAsNA+lLA+l	hTLSLDVPTNIMNILFslAKAKNlRApAAANA+LhAQI.	0	2	3	10
+11446	PF11614	FixG_C	Bre5;	IG-like fold at C-terminal of FixG, putative oxidoreductase	Pollington J, Coggill P	anon	pdb_2r39	Domain	This domain is part of a transmembrane protein, FixG, itself part of the FixGHIS operon closely associated with the FixNOPQ operon that is the symbiotically essential cbb3-type haem-copper oxidase complex. FixG expression is induced by oxygen-deprivation. This C-terminal domain adopts an E-set Ig-like fold.	25.60	25.60	25.60	25.90	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.69	0.71	-3.99	345	1156	2012-10-03 16:25:20	2008-09-11 09:45:12	3	18	966	1	346	998	117	120.90	25	25.60	CHANGED	hlhslspRsslclsVl+DRssLah.phscGp....IcNsYsl+lhNpsppspp.aplslp...G.............shpl...............s...........pplplsssps......tphslhlps..sspt...........ht...pssp.slphpl....p........t........s.stthp.sp.....pcopFhsP	.............................hhhslspRpshtlsVl+DRs.hhh..pp..ssGp....IcNsYsl+lhNpsppspp.aplslp..G..hs............slpl.............................t.....sppslpl.tsuchhplsVhlps..s.pt............hp...pssp...slphplp.......p.....s.ssphs.hp......pcopFlsP...................................	0	95	216	281
+11447	PF11615	DUF3249		Protein of unknown function (DUF3249)	Pollington J	anon	pdb_2pqr	Family	This family of proteins represents the gene product of the protein CAF4, the yeast protein YKR036c. This protein contains seven WD40 repeats in its C terminus. The function however is unknown [1].	20.70	20.70	20.70	151.10	19.50	17.00	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-8.99	0.72	-4.23	2	13	2009-09-13 21:11:59	2008-09-11 10:25:08	3	1	13	2	4	10	0	60.00	100	9.25	CHANGED	QKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQR	QKGQVGIFSFQNNYADSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSIIQQR	1	1	1	1
+11448	PF11616	EZH2_WD-Binding		WD repeat binding protein EZH2	Pollington J	anon	pdb_2qxv	Family	This family of proteins represents Enhancer of zest homolog 2, (EZH2) a 30 residue peptide which binds to a WD-repeat domain of EED by residues 39-68. EED is a component of PRC2 complex which is involved in gene expression [1]. This interaction is required for the HMTase activity of PCR2 [1].	25.00	25.00	32.00	30.80	18.50	17.20	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.14	0.72	-7.19	0.72	-4.08	6	144	2009-01-15 18:05:59	2008-09-11 10:59:13	3	3	38	1	55	146	0	29.80	68	4.73	CHANGED	KuhFsSNRQKI.E+T-ILNpEWKphRIQPl	...KoMFsoNRQKIhERT-ILNQEWKpRRIQPV.	0	2	6	21
+11449	PF11617	Cu-binding_MopE		Protein metal binding site	Pollington J	anon	pdb_2vov	Family	This family of proteins represents a unique protein copper binding site that involves a tryptophan metabolite, kynurenine in the protein MopE. The production of kyneurenin by modification of tryptophan and its involvement in copper binding is an innate property of MopE [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.57	0.72	-4.17	36	222	2009-01-15 18:05:59	2008-09-11 11:40:36	3	34	44	0	161	228	684	29.10	42	8.14	CHANGED	DCsDsssslpPGA..sElC.DulDNsCDGtsD-s	...........DCsD...tsstlhPuA....sE....lC.s..G.l.DssCsGthDp.......	0	78	87	128
+11450	PF11618	DUF3250		Protein of unknown function (DUF3250)	Pollinton J	anon	pdb_2yrb	Family	This family of proteins represents a protein with unknown function. It may be the C2 domain from KIAA1005 however this cannot be confirmed.	27.70	27.70	28.70	36.30	27.60	27.20	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.27	0.72	-3.85	11	173	2009-01-15 18:05:59	2008-09-11 13:07:17	3	8	74	1	82	129	0	107.00	44	9.07	CHANGED	TFCThsFaDFETpoTPlspGhpshYsFTopYsVphDsLhlpYLposulhl-LHpsh.upE..acTlAuutlshctll.....-psu.+ltuosshsususp..shGsl-Yhh+lphP	.............TFCTYuFYDFEhpsTPllp.G.pPtY.sFTSQYlVcscsLFLpYlQ...............psol.pLElHQAh..us-...acTlAAsplphcclL...................Epss........+.lauos...sL..s.Gsp......G-.....saGslEYWhRL+hP....................................	0	23	31	51
+11451	PF11619	P53_C		Transcription factor P53 - C terminal domain	Pollington J	anon	pdb_2rp4	Family	This family of proteins is the C terminal domain of the transcription factor P53. While the rest of the protein is quite conserved between the different transcription factors such as p53 and p73, the C terminal domain is highly divergent. The DM-p53 structure is characterized by an additional N-terminal beta-strand and a C-terminal helix [1].	25.00	25.00	56.50	55.20	21.80	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.46	0.72	-4.23	2	16	2009-09-11 05:01:43	2008-09-11 13:16:24	3	1	12	4	7	17	0	70.20	66	16.58	CHANGED	DDSAAEWNVSRTPDGDYRLAITCPNKEWLLQSIEGMIKEAAAEVLRNPNQENLRRHANKLLSLKKRAYELP	........A-WsVSRT.DGDYRLuITCPpKEWLLQSIEGMIKEAAAEVLRNPNp.-NLR+HAN+LLSLKKpAaELP......	0	1	1	4
+11452	PF11620	GABP-alpha		GA-binding protein alpha chain	Pollington J	anon	pdb_2juo	Family	This family of proteins represents the transcription factor GABP alpha. This alpha domain is a five-stranded beta-sheet crossed by a distorted helix termed an OST domain. The surface of the GABP alpha OST domain contains two clusters of negatively-charged residues suggesting there are positively-charged partner proteins. The OST domain binds to the CH1 and CH3 domains of the co-activator histone acetyltransferase CBP/p300, a direct link between GABP and transcriptional machinery has been made [1].	21.90	21.90	21.90	34.20	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.92	0.72	-4.00	5	88	2009-01-15 18:05:59	2008-09-11 13:47:53	3	5	69	1	55	81	0	86.80	60	19.93	CHANGED	s--lIVQcIDI+EPIusLKKLLEsRLplS.LctY-IaLQDhQ.L-PD+SLFDQGVKs-GoVQLSVQVQTt.s.ccKLNIlEIVKPs--Vcs	.......s.s-hlsQsIDINEPlGNLKKLLEPRLQsS.LDua-ICLQDIQ.L-P-+SLFDQGVKTDGoVQLSVQlh.oht.................G..-.KLNILEIVKPsEsVc.......	0	14	18	35
+11453	PF11621	Sbi-IV		C3 binding domain 4 of IgG-bind protein SBI	Pollington J	anon	pdb_2jvg	Family	This family of proteins represents Sbi domain IV which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation [1]. When not interacting with Sbi-III, Sbi-IV inhibits the alternative pathway without complement consumption. The structure of Sbi-IV consists of a three-helix bundle fold [1].	25.00	25.00	34.20	34.10	19.60	19.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.36	0.72	-3.82	2	163	2009-01-15 18:05:59	2008-09-11 14:00:45	3	2	160	4	2	45	0	68.00	96	16.01	CHANGED	VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVpcHLQKQLDALVAQKDAEKKVA	...........VSIEKAIVRHDERVKSANDAISKLNEKDSIENRRLAQREVNKAPMDVKEHLQKQLDALVAQKDAEKKVA..	0	1	1	2
+11454	PF11622	DUF3251		Protein of unknown function (DUF3251)	Pollington JE	anon	pdb_2jwy	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae. Some members if this family are annotated as putative lipoprotein YajI however this cannot be confirmed.	19.90	19.90	20.00	22.50	19.50	19.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.77	0.71	-4.84	7	846	2009-01-15 18:05:59	2008-09-11 14:18:11	3	1	485	1	36	261	2	165.70	41	85.84	CHANGED	CA.QpEl.ph+pslSpLNQchTpLsppssKlpQQNtLNAcSspGVYLLPuApTsuRL-SplGpLphSLtsIpstAsGopssL+Ips.SscsLPAFsApVEaGQlpuTotshtpsssQsQ.hsAPsSlLssS-ssIsLpLsGloP-QLGFlRlHslQP......lsp	.............................................................................................Qh+ppluTLppphTp.......lpppTspI...Tpps+.L......s......tcppps.la....L.P...utpp.hhLp.upIGsLthpllsIsPsssGoslpLcl.s..ssPls.shuhsspaGphpsTpsph.th.hQ...spL...h....N....ushplLsso.sDIsLpLKGlSPspLGal+Ip................shp....................................	1	1	6	20
+11455	PF11623	DUF3252		Protein of unknown function (DUF3252)	Pollington J	anon	pdb_2jz2	Family	This family of proteins has no known function. Some members are annotated as Ssl0352 however this cannot be confirmed. Currently there is no known function.	20.80	20.80	21.10	69.80	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.56	0.72	-4.56	16	94	2009-01-15 18:05:59	2008-09-11 14:25:39	3	1	88	3	43	88	112	52.90	62	50.51	CHANGED	hILPGssV+VpNssshYatapGhVQRloDGKAAVLFEGGNWDKLlTFpLsELE	...ILPGssVpVpNssssYatYpGhVQRloDGKAAVLFEG.GNWDKLlTFcLsELE.	0	7	28	39
+11456	PF11624	M157		MHC class I-like protein M157	Pollington J	anon	pdb_2nyk	Family	This family of proteins represents M157,a divergent form of MHC class I-like proteins which is the protein product of the mouse cytomegalovirus. This protein is unique in its ability to engage both activating (Ly49H) and inhibitory (Ly49I) natural killer cell receptors. M157 is involved in intra- and intermolecular interacts within and between its domains to form a compact MHC-like molecule [1].	20.60	20.60	21.10	21.20	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.79	0.70	-5.27	5	132	2009-01-15 18:05:59	2008-09-11 14:50:58	3	1	6	1	0	116	0	237.50	23	63.71	CHANGED	TVTRoGaHKRTISVsNGRPVVVWDsGDKNPKICKICPAVoSINsEYlFLDIQKMRLsNLLuQuLh-sQRICVRYsCLFL..+FDV.......lCDVYHTTD+VRlTYp+QTsKINIQGSGTFshSDAKshGlaMLpsNVcEIKp+WRsTVQpLKQLGYMNcTEVEFWYNT...TGLTTCVVTSRSNsPFTVELSLNTNSSAIVT.....EESTVDsQsVTVKAPGSasQRCYVTSSLGWKGVVT..PPSQYRTK......RsPVN.ISSSKhTGI	.........................................................................................h.......................................s.so-h...ssEhhFhtpQppaLpp.hhphl.tt.stt.........l.slcYpCpah....hhsh........tCpV..hhsss....psp..l.....hhh...........hs....sp.t..s.......ss..ps..........s.s........s...............h........s....s......scuhulphLpspsppIppRWpssspclhphup.scs-hpFhhsh......pGhspCslpSpuslhaplpl...s..s...s..s..s....s..tshss........shssh..hps.ss....sps.s.s..s..t....s....tChlpSohG.Wpsslp.........................................t.............................	1	0	0	0
+11457	PF11625	DUF3253		Protein of unknown function (DUF3253)	Pollington J	anon	pdb_2ns0	Family	This bacterial family of proteins has no known function.	20.60	20.60	21.10	22.00	20.00	20.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.83	0.72	-4.10	28	140	2009-01-15 18:05:59	2008-09-11 14:57:13	3	4	137	1	72	146	38	83.60	37	82.99	CHANGED	hsssspplctsILcLlupRusspolCPSElARAl.......us-s..WRthMssVRpsAtcLsptGclplppKGc....sV.DPssh.+GPlRlth..ts	...............................................h....ttplctsIlpLlspRus....spolCPSElARAl......................................us-s....WRsLMtslRcsAhcLspsGclpIhQ+Gc......sV...DPssh....RGslRlph...tt.........	0	26	49	61
+11458	PF11626	Rap1_C	Rap1_C; TRF2IP; Yippee-Rap1;	TRF2-interacting telomeric protein/Rap1 - C terminal domain	Pollington J	anon	pdb_3cz6	Family	This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres [1]. The Rap-1 C terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C terminal domain [1]. Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends from attack by DNA-repair mechanisms [2,3,4,5].	20.10	20.10	20.10	20.20	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.93	0.72	-4.10	81	175	2012-10-03 10:46:08	2008-09-11 15:24:49	3	12	150	7	118	164	1	88.60	26	15.59	CHANGED	lpp.hpphGh...spphls.pALtsoot-hthstp.llph.........hpt......sps.....................P.....sh.GlWTpcDDphLpss...................................sspshcp.............LhpKH...G.ppplptRhcFLpt	..............................................h....hpphsh...ststls.pALhpsSu-hthssphlhsh.................hpt..........sps.................................h..........P..sh.GlWTccDDpsLpts...................................-pcshcp.............LlcK+...G.spplptRhcFlp.t................................	0	25	52	88
+11459	PF11627	HnRNPA1		Nuclear factor hnRNPA1	Pollington J	anon	pdb_2h4m	Family	This family of proteins represents hnRNPA1, a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins are involved in numerous RNA-related activities [1].	25.00	25.00	25.00	25.00	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.23	0.72	-3.79	8	294	2009-01-15 18:05:59	2008-09-11 16:01:28	3	6	38	0	124	141	0	36.70	76	13.49	CHANGED	GssYNDFGNYsuQ.pSNYGPMKuGsaGGh.R..sSG.PYGGG	............GGuY.N.....DFG.N.YNN....Q.SSNFGPMKG.GN.FGG..R......SSG.PYGGG.............	0	1	3	7
+11460	PF11628	TCR_zetazeta		T-cell surface glycoprotein CD3 zeta chain	Pollington J	anon	pdb_2hac	Family	The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues [1]. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerisation and assembly with TCR [1].	25.00	25.00	30.20	42.30	19.50	18.80	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.46	0.72	-4.49	43	108	2009-01-15 18:05:59	2008-09-11 16:17:06	3	4	42	2	36	124	0	32.80	62	22.10	CHANGED	DPKLCYlLDGILFlYGlIlTuLaLRhKFp+uts	.DP+LCYlLDGILFlYGlIlTALalRhKhpcut....	0	2	4	7
+11461	PF11629	Mst1_SARAH		C terminal SARAH domain of Mst1	Pollington J	anon	pdb_2jo8	Family	This family of proteins represents the C terminal SARAH domain of Mst1. SARAH controls apoptosis and cell cycle arrest via the Ras, RASSF, MST pathway. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process [1].	22.70	22.70	22.70	35.10	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.58	0.72	-4.14	11	152	2009-01-15 18:05:59	2008-09-11 16:32:35	3	4	93	2	86	143	0	48.80	64	9.94	CHANGED	-a-FLKshoh-ELppRLtSLDspMEpEIEEl+pRYpuKRQPILDAI-AK	....Da-FLKsholE-LQpRLtuLDPMMEpEIEElRQ+YpuKRQPILDAh-AK..	0	25	30	54
+11462	PF11630	DUF3254		Protein of unknown function (DUF3254)	Pollington J	anon	pdb_2job	Family	This family of proteins is most likely a family of anti-lipopolysaccharide factor proteins however this cannot be confirmed.	25.00	25.00	26.50	45.80	21.50	17.00	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.16	0.72	-4.04	10	69	2009-01-15 18:05:59	2008-09-11 16:40:43	3	1	21	1	0	84	0	94.50	46	83.19	CHANGED	CpAQuhpsL.lsullsKlssL..Wcsucl-hLGHpCpapVcPsl++acLYa+G+MWCPGWT...sIpGEu+TRSRSGslp+ul+DFVpKAhppGLITEE-ApsWLs	..............CpAQ.apsl.suulssK.ls.sL..W+ssps-hLGHpCpashpPplKRapLYa+G+hWCPGWT...sIcGc.upT.RS+S.Gsstcss+DFVpKAhppGLITpp-Ap.WLp.	0	0	0	0
+11463	PF11631	DUF3255		Protein of unknown function (DUF3255)	Pollington J	anon	pdb_2joz	Family	Members in this family of proteins are annotated as YxeF however no function is currently known. The family appears to be restricted to Bacillus.	25.00	25.00	32.10	223.80	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.64	0.71	-4.50	2	18	2009-01-15 18:05:59	2008-09-11 16:44:32	3	1	18	1	3	17	0	121.40	77	86.84	CHANGED	lMloGCpQpK.-EsPFYYGTWDtGhtPGPhDGV+StTVTFTcDpVlpppVhpGRGEVthP..sYKVISQsTDGoIEIpYLG..aPlKSTLKRGcNsTLIWc..GppKTMTRI..KTGtE-tcEK	lMloGCQQpK.-ETPFYYGTWDtGLpPGPMDGV+StTVTFTKDcVlpppVIcGRGEVphP..AYKVISQsTDGoIEIpYLG..aPlKSTLKRGcNsTLIWc..GpTKTMTRI..KTGtE-tcEK..	0	1	1	1
+11464	PF11632	LcnG-beta		Lactococcin G-beta	Pollington J	anon	pdb_2jpk	Family	This family of proteins is LcnG-beta, which with LcnG-alpha constitute the two-peptide bacteriocin lactococcin G (LcnG). This family of proteins represents the N terminal domain which has an alpha-helical structure and is amphiphilic. Both peptides have a GxxxG motif which they use for interaction through a helix-helix structure [1].	19.90	19.90	78.50	78.00	18.90	17.00	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.68	0.72	-4.21	2	5	2009-01-15 18:05:59	2008-09-11 16:57:19	3	1	3	2	0	5	0	35.00	70	63.87	CHANGED	t.htWLsWlpPAh-FlpGhuKGhhKEGNKsKWKNl	KKWGWLAWV-PAYEFlKGFGKGAIKEGNKDKWKNI	0	0	0	0
+11465	PF11633	SUD-M	Nsp3;	Single-stranded poly(A) binding domain	Pollington J	anon	pdb_2jwi	Domain	This family of proteins represents Nsp3c, the product of ORF1a in group 2 coronavirus. The domain exhibits a macrodomain fold containing the nsp3 residues 528 to 648, with a flexibly extended N-terminal tail from residues 513 to 527 and a C-terminal flexible tail of residues 649 to 651. SUD-M(527-651) binds single-stranded poly(A); the contact area with this RNA on the protein surface, and the electrophoretic mobility shift assays confirm that SUD-M has higher affinity for purine bases than for pyrimidine bases.	22.40	22.40	23.10	83.20	21.70	22.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.65	0.71	-4.91	6	195	2009-01-15 18:05:59	2008-09-15 09:39:56	3	10	84	11	0	175	1	142.70	83	2.41	CHANGED	ssp.lhss.ussssssllsslshuapuMlpauKcpGhLhPlshDYsAhsKlLKR....hcspEGlhTs-GhcFYhYSpccPLp-V.pALNuhs+sllhhPFGalspGhsLA.SAssMRsLTVPasVllsScssVPlYpuYhsus	.........S.AFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQRKYKGIKIQEGIVDY.GVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAARCMRSLKAPAVVSVSSPDAVTTY.NGYLTSS..	0	0	0	0
+11466	PF11634	IPI_T4		Nuclease inhibitor from bacteriophage T4	Pollington J	anon	pdb_2jub	Family	This family of proteins represents IPI from bacteriophage T4. This protein is a nuclease inhibitor which is injected by T4 to protect its DNA from gmrS/gmrD CT of pathogenic Escherichia coli into the infected host [1]. The structure of this protein consists of two small beta-sheets flanked by N and C termini by alpha-helices. The protein has a gmrS/gmrD hydrophobic binding site [1].	25.00	25.00	25.30	93.50	23.90	18.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.57	0.72	-4.10	2	6	2009-09-11 14:10:27	2008-09-15 09:51:27	3	1	5	1	0	5	0	75.70	85	79.37	CHANGED	ATLTSEVIKANKGREGKPMISLVDGEElKGTVYLGDGWSAKKDGATIVISPAEETALFKAKHISsApLKIIAKsLL	ATLTSEVIKANKGREGKPMISLVDGEEIKGTVYLGDGWSAKKDGATIVISPAEETALFKAKHISAAHLKIIAKNLL	0	0	0	0
+11467	PF11635	Med16		Mediator complex subunit 16	Coggill P	anon	manual	Family	Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function.\	  Med16 is one of the subunits of the Tail portion of the Mediator complex and is required for lipopolysaccharide gene-expression [4]. Several members including the human protein, Swiss:Q9Y2X0, have one or more WD40 domains on them, Pfam:PF00400.	25.00	25.00	25.60	25.10	22.40	24.80	hmmbuild  -o /dev/null HMM SEED	753	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.19	0.70	-13.32	0.70	-6.57	18	264	2009-01-15 18:05:59	2008-09-15 10:38:09	3	7	176	0	170	275	0	534.40	21	81.27	CHANGED	pphts..scsssssIluhpWLssp+.slhhpptshhs........................tt.sssshappplp.h.PhGshHPsssKtuhlslp+sGtlc.laYQ........K.ssplsshp.p..............spphlsaAuIs.ssssp.llls....saSthspplphY+lplsW.............s.....sptsp....hcs........p...........PSlplpchps.h...csh...s.............................p.lhpLo+Lcllstss.......ts.susp...I..Llsass.s..............t.sSllpRapLspps............phlpshFtpls.ppsss....t..p.h.phchhsclhhpppltsIssthhsh...............................................................hlshhacDGoIphhcpsohplhsss................scssshloshhssGFpa.........Ppls.......................htlSPohsullhhctpGp........th.....hthhpsshss.pp.t...h....susshAhta..shuhphshuuDDlslllphpl..lpplsccp...........tppahssllsthhshhsh.......shDt.scthlDKlls.ppsl.KshsLQhtLG..pht......sscsss.c.....luhllLpL+shsh........h...h..hs.....................hsc.-hlhSLlssh+Wll-hhsYlhppLh.l.........h.p.t.............p.s..polshhlhhuphsRthlhphh.ptlppl....pthltth........phaslh.spus...........p.....hh...h....phh..sss.Plshsha.....EpaLsclsshhpt.......................................................................t.pttsp.thE.pLllpuplPsp......................ltthsphllsps.......sssltschchsslahhDhshLplupsccsp..hhth....ttt.lh....................hDslpph.lthp................................................................tsplRRCsRCs..slotsspss........ps.......tshtt...Whhha....hRpClCGGhWh.p	.....................................................h..........t..hth.ah...t.t................................................s.hh..ht...s.hs.as...h.uhlhlp.sG.lt.h.h................................p.p..ph.p.......................thlthushs..tts......hlhh....s.s....tp.....lphh+l.lphs...................p..............................s..sh.h..h.................................................tlsplphl............t...t.....l...lh...hhp................................tohl.pap.ltpt...............lp.hh.phs.........................hph.t.h...t..l.tlt...hs................................................................hlhhhhpDuslphhpt.shp......................p....h.p..tsuhpa.....t...........................hS.s.h.hh.hp.ptp...............h.hht.........p..............................hthhh.......hthh........s.-.h....hhh.............p.hs.p................h.tphht.h.p.hph.................-h.........tl.p.....l....+s.h.lt...t...t.............tp.hs...phshlh.lpl.+p..h...............................................c....hl..l.t.hpWhhchhhhhhtpl..........................................................tp.....h....s.t..h...h...lt..h........th.h...............................t.t.................................................h.........h.....ps....ht.h......phL.th....................................................................................................................................................................t....-..h...ts..s........................h......hh.....................................h..............l.t....t.....................................................hD.hpp..h..............................................................................................................................................h+tCs.RCs....s...............................hh....h..h........C........h.............................................	0	32	68	132
+11468	PF11636	Troponin-I_N		Troponin I residues 1-32	Pollington J	anon	pdb_2jpw	Family	This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity [1]. 	25.00	25.00	26.70	25.50	18.30	17.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.93	0.72	-4.26	5	46	2009-01-15 18:05:59	2008-09-15 10:53:55	3	2	30	1	15	41	0	32.20	66	15.79	CHANGED	EA..EEEEsVsc.PKP.....PPsssPP.lRRKSSANYRSYAT	..................sc....pp-sstps.PAP.....uP......lRRRSSANYRAYAT.	0	1	1	3
+11469	PF11637	UvsW		ATP-dependant DNA helicase UvsW	Pollington J	anon	pdb_2jpn	Family	This family of proteins represents the DNA helicase UvsW from bacteriophage T4. The protein is a member of the monomeric SF2 helicase superfamily and shows structural homology to the eukaryotic SF2 helicase Rad54. UvsW is thought to have a role in recombination and the rescue of stalled replication forks [1].	25.00	25.00	71.20	70.40	19.10	18.00	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.62	0.72	-4.29	7	32	2009-01-15 18:05:59	2008-09-15 11:21:53	3	2	31	1	0	24	0	54.20	63	54.58	CHANGED	ltuCpTl-GLpELEKYYsKRhKEl..-lpsoDDISlRDAluG+RpEhEsps-stcE	IuSCQTlEGL-ELEtYYcKRsKEs..ELKDoDDISlRDALAGKRsELEspD--pEE...	0	0	0	0
+11470	PF11638	DnaA_N		DnaA N-terminal domain	Pollington J, Bateman A	anon	pdb_2jmp & Jackhmmer:B3CS04	Domain	This family of proteins represents the N-terminal domain of DnaA, a protein involved in the initiation of bacterial chromosomal replication. The structure of this domain is known [1]. It is also found in three copies in some proteins such as Swiss:B5V0X4. The exact function of this domain is uncertain but it has been suggested to play a role in oligomerisation.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.12	0.72	-4.40	116	3333	2012-10-02 15:09:17	2008-09-15 11:28:02	3	9	3077	2	743	2291	1830	62.70	28	14.06	CHANGED	sshWp.pltppLcppluppp..asoWlpslph.th.sss...............lhltsPspFhtsWlppp..........YhcpIpphhpp	...............plWppsLp.pLp..c..c..ls..tsp...........assWl+.s.lps...pl.pcss...............lhlhuP....Np.Fs..h.-Wlcs+..................YhshIpphh..t.......................	0	255	491	630
+11471	PF11639	HapK		REDY-like protein HapK	Pollington J	anon	pdb_2jdj	Family	This family of proteins represents HapK, a protein of unknown function, with two homologues PigK and RedY. The monomer structure of the protein contains a four-stranded anti parallel beta-sheet, three alpha-helices and a short C terminal tail which it uses for dimer formation [1]. The surface of HapK has a deep cavity with consists of a kinked helix and a beta-four strand. HapK could be involved in prodigiosin biosynthesis, specifically the binding of a bipyrrole intermediate such as HBM or MBM [1].	25.00	25.00	30.20	32.60	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.38	0.72	-3.40	4	20	2009-01-15 18:05:59	2008-09-15 11:51:59	3	2	19	2	9	20	14	102.90	37	68.24	CHANGED	McsIlHKIRLhDlucssAFEsWVpssDYATCPcLPSVRuFDVaRVSspt-APFHYlElIplou.ctFc+DMpTssFtsLVpsFspMAEVVEEluGEpLusGYpA	.....MpsIlH+I+L+DusssssFEpWVcsoDYssCspLsSVpuFpVh+l.S....s...s.s-....A.......P.aH...YlElIcVsuhctFs.p-MpTpsFpcLsscFsphA-VVpEhsGc.ltsGYt...............	0	6	7	7
+11472	PF11640	TAN		Telomere-length maintenance and DNA damage repair	Wood V, Coggill P	anon	Pfam-B_6865 (release 23.0)	Domain	ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalian CHK2). In addition to functioning in the response to DSBs, numerous findings indicate that Tel1/ATM regulates telomeres. The overall domain structure of Tel1/ATM is shared by proteins of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family, but this family carries a unique and functionally important TAN sequence motif, near its N-terminal, LxxxKxxE/DRxxxL. which is conserved specifically in the Tel1/ATM subclass of the PIKKs. The TAN motif is essential for both telomere length maintenance and Tel1 action in response to DNA damage [1]. It is classified as an EC:2.7.11.1.	21.40	21.40	21.40	23.20	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.79	0.71	-4.49	24	182	2009-01-15 18:05:59	2008-09-15 12:47:21	3	6	154	0	117	188	0	151.90	24	6.10	CHANGED	Msshth....t.hhshLpSsKl+-Rsculpp.....Lppllpss...................pplssKshctlhcuLhphlppE+pta.........ppsssttuss...tpRLspsupslRhhlcpulc............ph+h+shpsllspIhchhhsss......tslhpslshDas+sL.sslLphssahccLs.tppWpp	..............................p..l...shptLpss+hp-Rpctl-c..................hcpllppspt...................pphppt..sa..cslFc.sLh+hlppEppsh.....................htpsssssust..ttp+lpchuuhlRhhl....cpusc............+htphpsptLlsalh-slhsss........hhtshut.DasphL.pslLshphahpclu.pppW..p...................................	0	24	52	89
+11473	PF11641	Antigen_Bd37		Glycosylphosphatidylinositol-anchored merozoite surface protein	Pollington J	anon	pdb_2jo7	Family	This family of proteins represents the core region of Bd37, a surface antigen of B.divergens which is GPI-anchored at the surface of the merozoite. The structure of the protein consists of mainly alpha folds and has three sub domains [1].	25.00	25.00	180.60	180.40	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.60	0.70	-5.06	4	14	2009-01-15 18:05:59	2008-09-15 13:13:05	3	1	2	1	0	15	0	205.90	60	73.07	CHANGED	VKoLE....slRpELKGQREsFLScIIcSsGshTILQLVsaLRVlDTDLLLpVDusKV-cAGtKVKAYL-pIGI+GpsVEEuLDNLMhKVh.clT+GTVEuSsQuTD.SEELKsLLLKFSEDLKAEQEhHu-Kctoc.-LLp...sLpsp+DELlKKFsthsPoFLToEDISuFLTVP-YGsPhsuuKWKpVE+KIpD...KLESSDlsT..-LKoLlAcLIEQREpMMDLLYGPhGca	..VKTL-....-LRpEL+uQREphLSpIIcSDGPFTILQLlsaLRlIDTDLLLKVDpshVccAGcKVKsYLEpIGIsG-SVEtuLDpLMhKVY.clT+GTVcSsspuTD.SE-LpoLLLKFSEDL+AEQEhHupKctuc.cLlp...ohtpp+-ELlKKFsslsPTFLTsEDlSuaLsVP-YGhPhsuschKpVEthIpt...KLEoS-l.s..pL+sLlAclI..REphMDLLYG..Gc..	0	0	0	0
+11474	PF11642	Blo-t-5		Mite allergen Blo t 5	Pollington J	anon	pdb_2jmh	Family	This family of proteins is Blo t 5, an allergen protein from Blomia tropicalis mites. This protein shoes strong reactivity with IgE in asthmatic and rhinitis patients. The structure of the protein contains three alpha helices which form a coiled-coil [1].	20.70	20.70	20.70	21.70	20.30	18.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.66	0.71	-4.34	7	41	2009-01-15 18:05:59	2008-09-15 13:22:55	3	2	9	8	0	46	1	113.40	44	85.15	CHANGED	hststhsspD-aRpEFDRLLlpphpc+hcclE+tLhpLScQlpELEKoKSK-lKtpILRElolu.sFlcGApGahERELKRTDLNhhE+aNFEtALuTuplLhKDLppLtK+VKulcoc	.........s.....spcDc.aRNEFD+LLhpphpcphcchEctLLtLocQls-LEcoKoKEhK-pIL.RElsls.shIcGu+sahpRELKRTDLNlhE+aNaEtAlsosclLhKDLcchpp+VKslc....	1	0	0	0
+11476	PF11644	DUF3256		Protein of unknown function (DUF3256)	Pollington J	anon	pdb_2p3p	Family	This family of proteins with unknown function appears to be restricted to Bacteroidales.	25.00	25.00	40.40	39.40	20.80	19.40	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.07	0.71	-4.81	9	96	2009-01-15 18:05:59	2008-09-15 14:03:42	3	1	96	2	13	81	0	195.30	36	92.44	CHANGED	hhsshulpAQEhKTlFlsMPDSlsPLLopVNRcDhI....DFlpSpMKApVcNpFGtpSEhpcLosDYlplQhospSohpMKlLsLsDoTpVlCsVoTVCuPACDSpl+FYTTDWK.LssssFl.olPshsDFlt.ssDoss.Ysap-ApppADM.LMKscLSc-sspLohThTTP-YhuKEstEKLcPFLR+.PlVYpWcsG+Fp	.......h....hulpAQ-h+slFlsMPDSlsPhLo+ssRpDhl....Dalp.uc.MKApVcNpFGspS..chpcLos..DYlplQhospSohpMK.lLslssosp........lICsVsTssu..PssDSclcFYos-Wc.Lssspah...shPshssF..lt.....ssDohs..cap-hppphDhhLhpscLSt-sspLohohoTPpYhucEstE+lcsaL+c.PllYpWpsspF..................	0	5	11	13
+11477	PF11645	PDDEXK_5	DUF3257;	PD-(D/E)XK endonuclease	Pollington J	anon	pdb_2ost	Family	This family of endonucleases includes a group I intron-encoded endonuclease [1]. This family belongs to the PD-(D/E)XK superfamily [2-3].	21.50	21.50	21.50	21.60	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.92	0.71	-4.52	2	21	2012-10-11 20:44:46	2008-09-15 14:40:57	3	1	20	4	4	13	7	133.70	33	94.51	CHANGED	STKLKGDIAEQAAILRALKLGWGVLKPLGDRLSYDLVFDVEGILLKVQVKSSWFSEKTGNYVVDNRRTRTNRRNIVRSPYRGNDFDFAVAYVEELELFYVFPVDVFISYGSEIHLVETDKRQRKPRSFGYREAWHLILQKGAAQKETSA	.........p.TK.KGDlA.ttAhlchlchGasVLpPhuD+.sYDLVh.............-.t-GlLh+VQVKouhhsppsGhh.VcpRsoh.oscpslsppphpsp-hD.ahlsYstph-.hYhFssclF.............................................h...h..pt.............................	0	2	4	4
+11478	PF11646	DUF3258		Protein of unknown function DUF3258	Pollington J	anon	pdb_2oq8	Family	This viral family are possible phage integrase proteins however this cannot be confirmed.	25.00	25.00	27.20	70.10	19.70	17.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.31	0.72	-3.88	4	7	2009-01-15 18:05:59	2008-09-15 14:47:15	3	2	7	4	2	11	0	101.90	39	21.51	CHANGED	P..hhuclYhchL.tph.K.sLpshpppDYARa.llWstls.DttI--..........ah.+DIuh.lDpsapLsK.hphcP.Yp+huWsEc.NhslsEDDlhhscolt+Y	.......hScVYh-FLpaKlpKtsLssKhppDYARhallWphlscDtsI-p..........Yps+DIGhFIDpCapLPK.hNhtP.YsKMuhsEclshDVsE-DhlsPKoVp+Y	0	0	1	1
+11479	PF11647	PMT_C		C-terminal region of Pasteurella multocida toxin residues 569-1285	Pollington J	anon	pdb_2ebf	Family	This family represents the C terminal region of Pasteurella multocida toxin (PMT) which displays a Trojan horse-like shape with three domains, C1, C2 and C3. The C3 domain possesses the Cys-His-Asp catalytic triad. PMT is an enzyme toxin carrying the cysteine protease-like catalytic triad which functions on the cytoplasmic face of the plasma membrane of target cells [1].	25.00	25.00	26.40	25.10	23.20	21.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.00	0.72	-4.36	14	184	2009-01-15 18:05:59	2008-09-15 15:09:40	3	27	97	6	23	185	1	66.70	40	3.18	CHANGED	osppLhcp..ups.GhsIGESapplhuchtllcsh..L....tpppVpsha.....l-chls-p.sushssh	.........oVsELl-s..ApVsGKlhGESYQpVlDtLs.hH....suhh.....t.-sVcpLh.pLp+pIEuYlhsHPsSGRspA......	0	1	5	16
+11480	PF11648	RIG-I_C-RD		C-terminal domain of RIG-I	Pollington J	anon	pdb_2qfb	Family	This family of proteins represents the regulatory domain RD of RIG-I, a protein which initiates a signalling cascade that provides essential antiviral protection for the host. The RD domain binds viral RNA, activating the RIG-I ATPase by RNA-dependant dimerisation. The structure of RD contains a zinc-binding domain and is thought to confer ligand specificity [1].	25.00	25.00	26.20	25.00	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.84	0.71	-4.25	14	227	2009-01-15 18:05:59	2008-09-15 15:56:30	3	13	67	45	119	217	0	117.10	32	14.61	CHANGED	cphpLLCtsCpshsshusDlRpVEsoHaVslsssFp.chapspppPhs.tKhac-ap.supIpCtp..CucsWGhthhYKusp.LPsLKIcuhl....hEs.stsphphpKWpclsFphspF.Dhs-hstts	..............hpLLCp..pCpshsCpusDI+h.l.EpsH+Vsl.sss.Fp..phah.spt.p...p..s.t+pat..-ap..hs..upIhCpp.....Cup.sWGhhhha+s..hc...L..P..sLKI+sFV..h.hps....sts+p.ph.+KWpcls..hph.s.h.Dh.phs..t................................	0	33	40	72
+11481	PF11649	T4_neck-protein		Virus neck protein	Pollington J, Finn RD	anon	PRODOM	Family	This family of protein represents gene product 14, a major component of the neck in T4-like viruses along with gene product 13. Gene product 14 is rich is beta-sheets. The formation of the neck to the head of the bacteriophage is crucial for the tail attachment [1].	25.00	25.00	26.90	26.50	18.40	17.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.39	0.70	-5.09	12	78	2009-01-15 18:05:59	2008-09-16 09:11:18	3	2	77	0	0	70	1199	236.50	35	80.71	CHANGED	M......................s.psphhNPYl..........NhppasspQsLt-sLVsESIphpGl-hYYlPREaVshD.lhsEDhpoKFp+uaphtAYlsoaEGYpGpssahSKFGhplsDEhThsls.chFppps........DGp..........cPppGDLIYF.....Ph...sNsLFEIsaVEs.cPFYQhGcshhhclpsppFhYSuE-l...pPt.....lpc.-sl..-ph.t.slt.lhslsGhsDhsltp....htcssphpscstchhpph.slsscu...................osFssh	..............................................tpp.hssYl..........Nh..stapspQpLh-sLVsESIphhGh-lYYlPRphVshDhlauE-.psKFspA..aphtAYlssaEGapGttshhSKFG.hplpDElThsls.phFccpl............ssp................cP.pEGDLIYF.....Ph...sspLFEIsaVE.....s.cP.....FYQhG+shlhclpsphF.YS.sE-l...sss.....lpc.-sI......p....ph.t.slp.lhslsGhs-hshsp....htpssphpscstp.h.....l.sts........................s...............................................	0	0	0	0
+11482	PF11650	P22_Tail-4		P22 tail accessory factor	Pollington J, Finn RD	anon	PRODOM	Family	This tail accessory factor of the P22 virus is also referred to as gene product 4 (Gp4). The proteins structure consists of 60% alpha helices. Gp4 is the first tail accessory factor to be added to newly DNA-filled capsids during P22-morphogenesis. In solution, the protein acts as a monomer and has low structural stability. The interaction of gp4 with the portal protein involves the binding of two non-equivalent sets of six gp4 proteins [1]. Gp4 acts as a structural adaptor for gp10 and gp26, the other tail accessory factors [1].	19.40	19.40	19.40	22.70	18.60	18.10	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.79	0.71	-4.68	6	137	2009-01-15 18:05:59	2008-09-16 09:28:17	3	1	135	24	8	65	4	158.50	51	97.54	CHANGED	MsplhTKGDlVLhALRKhGlASNATLTDVEPQShEDGlNDLEsMMAEWh....upGI-lGYtFAssEps..PsPDD-oGLssphpsAVuapLhlRlhsDYulEPTs+lluoActuY-sLhhshlplPulcRRs..........DMPsGpGNpassasss+YYsc+t.....hssDss......ss	.......................M.plhTKGDlVLtALRKhGlASNATLTDVEPQShEDuVNDLEsMMAEWh....upGIsl.GYhFAssDps..PhPsD-pGLsspAhsAVhapLAsRlssDYuLEsospllosAchuh-tL....hKlsuhc.Rtp..........cMPsGSGNphssast.+Ya.tct......stD.sss............	1	3	3	5
+11483	PF11651	P22_CoatProtein		P22 coat protein - gene protein 5	Pollington J	anon	PRODOM	Family	This family of proteins represents gene product 5 from bacteriophage P22. This protein is involved in the formation of the pro-capsid shells in the bacteriophage. In total, there are 415 molecules of the coat protein which are arranged in an icosahedral shell [1].	23.70	23.70	24.30	23.80	23.50	23.60	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-11.94	0.70	-5.87	13	302	2012-10-03 06:22:39	2008-09-16 10:33:18	3	5	281	0	45	236	443	327.50	22	91.19	CHANGED	MANshLT..hslIscEslcslpspsshupslc+tYsspF....suhphGsolslhhPsphpststsshs.........sspslsEtpVslslsp.csVshphoucEhtLcls-hpcRhl+PAhppLAspl-uslht.............shtppsoNhVup...ssush..s.hsshtsAsstLspttlPps.sRpshhsPpspschuss.sshhtsu.ptspsAaccusl.sphuGhDhhhspslhstssGu.usuhTVsGusphss...................Tlslsuhss..........lptGDhhohAGVhtlp.lTKpsh...sp.ppFpVst.....usuusslpIhPshlssssss.sp....atsVssssAsssslohlsssssshh.NLhapcsAhsLsssPL.hPhtuuspshssoa....cGlSlRlhsthDtpscsspsRlDlLYGs.sslcP-h.ultlss	.........................................................................................t....h.hhpthl.th..t.hs.hsp..t..lp+.htsst......s.p.tssssl..hh.Pst.ps.....p....tp....shshss......ssssl.ptps.s.sphsp.cps.hphps..-....l..p.....t....p.hh.p...phl....p....sutptLA....ssl-ptl.u...p.......................hhhp.t.u..u..h.s.l..s.................s.....s.....s..sst.ps.......as.l.upstphlpstslsps..sphhlh..sPtshtp..ht.ts.st.h.ths..s...phsppA..h.c.supI..spl..uGhchhho.....sshh.....h.pts...u.s..s.hhlpst.p.t....................hlslssss.........hthGp.hphss..................................................................................................hht...h.hh......s...........................sh.h...................thth..u..................................................................	0	14	29	36
+11484	PF11652	DUF3259		Protein of unknown function (DUF3259)	Pollington J	anon	PRODOM	Family	This eukaryotic family of proteins has no known function.	25.00	25.00	34.20	48.80	21.00	18.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.89	0.72	-3.83	4	92	2009-01-15 18:05:59	2008-09-16 13:06:44	3	1	42	0	59	80	0	82.20	64	46.83	CHANGED	MplQDpQLAtQLhRLRu-Ip+LKl-QsC+hH+EMLsDATaELEEps-.uDL.CDlPhuuuhuLSTPLKhlGlTKMNINoRRFSLC	....MphQDpQLARQLhRLRu-Ip...+LKlEQsC+LH+cMLsDAoaEL.EEp....sE........uDL..hC-h...Phs...u.uhuL..SsPL+hIGlTKMNINSRRFSLC.	0	6	12	28
+11485	PF11653	VirionAssem_T7		Bacteriophage T7 virion assembly protein	Pollington J	anon	PRODOM	Family	This family of proteins represents the gene product 7.3 from T7 bacteriophage. The protein is localised to the tail and is thought to be important in virion assembly. Particles assembled in the absence of the protein fail to adsorb to cells [1].	25.00	25.00	26.00	25.60	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.30	0.72	-3.23	5	48	2009-09-11 12:45:27	2008-09-16 13:30:53	3	1	31	0	0	44	0	92.00	51	99.01	CHANGED	MG..KKIKKAVKKVsK.VpKl....s+.sttAuGGhLG..GGcstsp.V.......EAssP.As....AQlVEVP.cDcV-oED-uQTESu+KKARAuGKKuLSVARSSGGGINI	.......................................K.lpKshKpVsK................ht.st.pssGGhhG....GGpscsphs.............psPQAA.....AQlV....-VP.cc-VssED.-AQTESG+KKARAGGKKSLSVARSSGGGINI.............	0	0	0	0
+11486	PF11654	DUF2665		Protein of unknown function (DUF2665)	Pollington J, Finn RD	anon	PRODOM	Family	Some members in this family are annotated as Non classical export proteins, however no specific function is known.	21.90	21.90	23.10	22.40	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-8.15	0.72	-4.39	8	66	2009-01-15 18:05:59	2008-09-16 13:38:40	3	3	66	0	48	65	0	46.30	35	57.78	CHANGED	YLISRslDPlLAlulGssSYYLaEp..Rs..GRPpGHoLNELlt++ascps	....YLISRhhDPlhAlhlGssAaalhpp..Rp....t+.pG+.plpp...ll..h.h.................................	0	16	28	44
+11487	PF11655	DUF2589		Protein of unknown function (DUF2589)   	Pollington J, Finn RD	anon	PRODOM	Family	This family of proteins has no known function.	21.00	21.00	22.30	21.90	20.90	20.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.98	0.71	-4.12	34	199	2009-01-15 18:05:59	2008-09-16 14:19:00	3	3	97	0	60	181	27	153.20	21	77.55	CHANGED	shssLIsG.hpAsspAQthluppthchlpphh.............pssp.............hshphphslssppt.............php.lplPLlsllshssLtlcclslcFshclss..spsppsppstshph......psp.t................sspppssp......psssssphplplphpppssPEGlt+ll-hhsps	....................shppllsu.htAsspAQthhup.pthshlpphhh............psst..................hhhthphphslsspp.........................p.t.lplPLlsllshssL.tl-cssl..sFphcl..ss.spsppspsshphph......................thp.thh................hthpsphuspppssp..........psspssphp..lplphptpt.PEult+ll-hhsp............................................	0	9	25	47
+11488	PF11656	DUF3811	ComReg_Spx;	YjbD family (DUF3811)	Pollington J, Finn RD	anon	PRODOM	Family	This is a family of proteobacteria proteins of unknown function. This family is unrelated to Pfam:PF03960 which contains a set of transcription factors that are also named YjbD.	21.50	21.50	48.00	47.90	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.98	0.72	-3.92	6	505	2009-01-15 18:05:59	2008-09-16 14:21:29	3	1	502	0	25	113	1	86.90	83	97.82	CHANGED	M.+LT.KDMTESEQRElKTLLD+ARhstGRsLTNuEsN+IK-EhI-KlMspREthAKtAR.......tE+KppphpP.opsTFSW..SAss.usRu+R	......LPRITQKEMTEREQRELKTLLDRARIAHGRsLTNSETNSIKKEYIDKLMsEREAEAKKAR.......QLKK..KQAYKPDsEASFSW..SANT.STRGRR.........	0	1	6	14
+11489	PF11657	Activator-TraM		Transcriptional activator TraM 	Pollington J, Finn RD	anon	PRODOM	Family	TraM is required for quorum dependence. It binds to and in-activates TraR which controls the replication of the tumour-inducing virulence plasmid. TraM interacts in a two-step process with DNA-TraR to form a large, stable anti-activation complex [1,2].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.66	0.71	-4.71	11	77	2009-01-15 18:05:59	2008-09-16 14:26:03	3	1	62	0	11	52	8	141.40	40	96.89	CHANGED	MsDcI-ElI+-IAsKHGIAVuRDDPILlLQTINsRLMpDSp+AQQEhL-pFKEELEuIApRWGsDAKsKAERlLNAALuASKEAMs+shp-uspuuAcAl+pEl-suLuc.lsu.lpcuR+luhhNllAuuhslhAAslslhshL	........sDcl-ElIcEIAsKHGIAluRDDPILlLQTINp+LhpDo....tpAQ...p-lL.-pFKpELEuIupRWu..-D....AKsKAE+hLNAALs......ASK-A...Mscs.hp...-us....ptuuc..ul+c...E...l.-sshsp.l..ts...lccu..R+luh...hNhlAushslhAuslslas......................................................................	1	2	5	10
+11490	PF11658	DUF3260		Protein of unknown function (DUF3260)	Pollington J	anon	Pfam-B_003054 (release 23.0)	Family	Some members in this family of proteins are annotated as YhjU however this cannot be confirmed. Currently this family has no known function.	24.80	24.80	38.30	38.30	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	518	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.78	0.70	-6.36	23	576	2009-01-15 18:05:59	2008-09-16 14:50:18	3	1	549	0	49	313	9	502.60	71	95.59	CHANGED	hWNlYFllKFuLaatGhlsFpsLhNLsFsshLll..Pls...pptl+hlRphlAlslulsLhaaDoaLPPhsRLhuQsupltsFShuYLlELluRFlshphlluhhllllsYhhlupWlRlosaV.........lsuLlhlslhshsssshshhsusss..........................sstspssstsssssssshsshLssFappEupRpssFss..sssupsFDlLVLsICSLuWDDL-sstlpsHPLhs+FDllFcNFNSATSYSGPAAIRLLRASCGQpuHssLYpPAs.pQCaLFsNLApLGFpspllhNHsGcFDsFLp.l+cp.GshpsPlhspsulssshpuFDGSPIacDhsVLspWhp.pR.psssstsAhaYNoIoLHDGNRlssu.th.sohsSYthRtp+Lh-DlspFhcpLcpSGR+lhVllVPEHGAAL+GD+hQluGLREIPoPsIsHVPVGlKllGh..tssppGsslpIspPoSYLAlSpLlu+llssssFpsss.shtpLspsLPpTphVuENssslVMphsu+.Yl+LsG.usW	.................G.WNFYFLVKFGLLWAGYLNFHPLLNLVFAAFLLM..PIP...+YpLHRLRHWIAlPlGFALFWHDTWLPGPpSIMSQGoQVAuFSosYLlDLlsRFINWQMIGAIFVLLVAWLFLSQWIRlTVFV.........VAILlWLNVLTLuGPuFoLWP.....AGQPTsTVTTTG............GNAAATVAssGssPV.lGD.hPAQTAPPTTANLNAWLNsFYsAEuKRKoTFPusLPu.DAQPF-LLVINICSLSWSDlEAAGLMSHPLWSHFDI.FKNFNSATSYSGPAAIRLLRASCGQsSHTsLYQPAs.N-CYLFDNLuKLGFTQHLMMsHNGpFGGFLKEVREN.GGMQoELMs.QosLPVhLLuFDGSPVYDDhAVLNRWLs.spE.+-p.....NSRSATFYNTLPLHDGNHaPGV....SKTADYKsRAQKhFDELDAFFTELEKSGRKVMVVVVPEHGGALKGDRMQVSGLRDIPSPSITcVPVGVKFFGM..KAPHpGAPIlI-QPSSaLAIS-LVVRllDGKlFTE.D..s.......VsWpKLTSsLPQTAPVSENuNAVVIQYQsKPYVRLNG.GDW....................	0	6	14	32
+11491	PF11659	DUF3261		Protein of unknown function (DUF3261)	Pollington J	anon	Pfam-B_003077 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	26.00	25.70	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.91	0.71	-4.63	32	248	2009-01-15 18:05:59	2008-09-16 14:52:44	3	1	246	0	60	186	11	157.50	39	79.73	CHANGED	lhsL.lLsuCup.p..pps.s.....lsls.ssplsLssssths............................................hshsQhlohphssp....p.......+pLhspLcl-sp.clsLsGhushGptLhsLsYDspslpsppt..hLsssl...scplLusl.LshWPhpuhpstLs...GhpLtsps............ppRp.lhspssph.............llcIcYpp	...............................................h.hsL.hLsGCSp..p..ppps.....pshLpsss..plsLPsPuhsss...........................................lstQQLlousasuc.....o.........poLLVhL..psDsp..+lsLAGLSulGhRLFhlsYD.u.pslcsEQu..llsspL.PPApQVLADlMLoaWPhuAWpspLs..sGWpLpDsu....................spRp.LhsssGpl.............ls-IpY..t............................................	0	9	19	40
+11492	PF11660	DUF3262		Protein of unknown function (DUF3262)	Pollinton J	anon	Pfam-B_003096 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	23.50	23.50	23.50	23.50	21.90	23.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-9.76	0.72	-3.88	24	210	2009-01-15 18:05:59	2008-09-16 15:02:28	3	2	173	0	64	172	6	74.10	33	90.38	CHANGED	MouAQtsAFpAu.SG.lsPsthsslhlGhllulLhLWusWAlhssYpGWusp.plsptshhtsslRhslLLlVlsaahh	......MssuQhuAFpAu..oG..hsPushshlhlGhlhulLLLWusWAhhosYpGWusp..plsptphhthslRhlhLhllhsFhhh.......	0	4	30	52
+11493	PF11661	DUF2986		Protein of unknown function (DUF2986)	Pollington J, Finn RD	anon	Pfam-B_003109 (release 23.0)	Family	This family of proteins has no known function.	21.30	21.30	23.70	49.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.27	0.72	-3.63	42	221	2009-01-15 18:05:59	2008-09-16 15:04:49	3	1	191	0	59	167	4	44.50	59	68.34	CHANGED	MNRKKKIsphLpp+sK+sNAKlps..ss...KP+YISKAER....tKltupsp	.MNRKKKIsQhLpp+tKKtsAKLcs...SN.....KP..+YISKAER....AKLsAcpt.......	0	6	14	39
+11494	PF11662	DUF3263		Protein of unknown function (DUF3263)	Pollington J	anon	Pfam-B_003189 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Actinobacteria.	22.30	22.30	22.30	22.40	21.80	22.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.33	0.72	-4.52	18	368	2009-01-15 18:05:59	2008-09-16 15:51:34	3	1	342	0	112	259	77	76.40	49	76.45	CHANGED	ssLocR-ppILcFERQWW+asGA..KEpAIR-pFulSuTRYYQlLNsLIDsPtALttDPMLV+RLRRLRssRp+sRuAR	......s.tLop+-+sILsFEcpWa+.......hu.Gu...KEpAIR....-phGlSusRYYQhLNtLlDcscAlstc..PhLVpRLRRlRu...pRp+uRuAp.....................	0	39	89	107
+11495	PF11663	Toxin_YhaV		Toxin with endonuclease activity YhaV	Pollington J, Finn RD	anon	Pfam-B_003231 (release 23.0)	Family	YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity [1].	22.80	22.80	23.20	51.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.86	0.71	-4.44	17	374	2009-01-15 18:05:59	2008-09-16 16:06:56	3	1	357	0	48	161	27	138.30	65	91.19	CHANGED	plaAHshFl-pL-tLhspVEph+t+DPpsYtp+sssKhLAAlh+Lhh-sIPtDPs+spaRQGsTLGs.c++HWhRA..KFhp.paRLFFRa..copu.KlIlhAWVNDEsThRsYGu+sDAYsVFp+MLspGpPP-DWssLLptupsp	.........................A.LYAHPCFQETYDALVAEVEsLKGK.DPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGS...GKNKDWSRVKFGA..GRYRLFFR.Y..SE.KE..KVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWEoLTpETEEs........	0	12	30	42
+11497	PF11665	DUF3265		Protein of unknown function (DUF3265)	Pollington J	anon	Pfam-B_001494 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Vibrio.	20.60	20.60	20.80	20.80	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.72	0.72	-6.86	0.72	-4.10	16	241	2009-01-15 18:05:59	2008-09-16 16:28:22	3	5	69	0	28	244	0	26.70	45	50.19	CHANGED	+sAhHFhaAlsFsscssstphulushsP	.+sAWHFaYALshVhKlVCuuhGIAhlTP........	0	0	0	15
+11498	PF11666	DUF2933		Protein of unknown function (DUF2933)	Pollington J, Finn RD	anon	Pfam-B_002197 (release 23.0)	Family	This bacterial family of proteins has no known function.	20.30	20.30	20.30	20.30	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.08	0.72	-4.43	40	286	2009-01-15 18:05:59	2008-09-16 16:47:17	3	2	243	0	91	187	35	55.20	43	68.32	CHANGED	hlshhslAuaaLlsEHpAHl...hGhL...PaLLL.LACPLMHlFM.HGGHGsHupccsssps.s	..........................lshhulAuahLlpEHhuHl....hGhh...PaL..LL.LlCPL....MH...L....Fh...H...G.GH.GsHpccsspsp.p..............	0	15	45	74
+11499	PF11667	DUF3267		Protein of unknown function (DUF3267)	Pollington J	anon	Pfam-B_002418 (release 23.0)	Family	This family of proteins has no known function.	27.10	27.10	27.30	27.30	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.50	0.72	-3.86	44	858	2009-01-15 18:05:59	2008-09-16 16:53:05	3	1	553	0	83	438	6	109.10	28	60.12	CHANGED	lslllhl.hlHEhlHhlhahhhttp..pht.hthphthhhhash.sspsls+ppahlhhlsPhlllohlhhhlhhh....h..htsshhhhlhs....hpsuhsssDhhhhhhllpp..spsshlp	....................h.hhllhh.hlHEhIHhlhFhhapcs....Ksp.hth.phchl...h.hats.ssp..shsKhpFp.IhhlhPh..llloshhlhLhhh.................hhh...p..hhh.F.lhu....lpsuhshsDlhhltlllpp..spsphl...............	0	30	56	74
+11500	PF11668	Gp_UL130		HCMV glycoprotein pUL130	Pollington J	anon	Pfam-B_002736 (release 23.0)	Family	This family of proteins represents pUL130 from Human cytomegalovirus, a glycoprotein secreted from infected cells that is incorporated into the virion envelope as a Golgi-matured form. The protein promotes endothelial cell infection through a producer cell modification of the virion [1].	25.00	25.00	54.70	54.30	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.03	0.71	-4.71	4	61	2009-01-15 18:05:59	2008-09-17 09:14:16	3	1	11	0	0	55	0	141.30	64	69.22	CHANGED	aCP.haPSPPRshu.FouYcphssGPECsNpTLYlLaNRpGQpLIERPSsWVpKlsaYLSGRspsVFQ+Fs+sAoosoc.slpIos-DtKlFGAHMlPKpoKhLRalVpDGTchphC.M+lpTWA+shpsY.luFQsRlphTpAspps.ohCT+PNLlV	............YCPFlYPSPPRSP.QFSGFQpVsTGPECRNETLYLLYNREGQTLVERSSTWVKKVIWYLSGRNQTILQRMP+TASKPSDGNVQI.SVEDAKIF.GA....HM..VPKQTKLLRFVVNDGTRYQMCVMKLESWAHVF...RDYSVSFQVRLTFTEANNQ...T...YTFCTHPNLIV...............	0	0	0	0
+11501	PF11669	WBP-1		WW domain-binding protein 1	Pollington J	anon	Pfam-B_003402 (release 23.0)	Family	This family of proteins represents WBP-1, a ligand of the WW domain of Yes-associated protein. This protein has a proline-rich domain. WBP-1 does not bind to the SH3 domain [1].	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.04	0.72	-10.85	0.72	-3.94	9	225	2009-01-15 18:05:59	2008-09-17 10:46:17	3	5	71	0	128	194	0	96.00	42	32.88	CHANGED	YhC.-oGaCCGEotCC........................oYYYELWWFWLVWsllIlLuCCCsh+HRRsKpRL.....QpQQRQ+EINLlAYptApp......os.sh.hRhLssahLPsYEEVss+PsTPPPPYo	.........YhC..-s.GaCCG..p.o.....tCC.....................sY..YYELW.W.F.......W.......L...lWsl..l...I..l...L...S.CCCsh....+HR...Rs.KhRL.......QpQQRQ+EINL.hAYptApph........ss..h.....h......ph.hssah.PsYE-Vspp..P....s..oPPP.PYo........................................................	0	21	33	76
+11502	PF11670	MSP1a		Major surface protein 1a (MSP1a)	Pollington J, Finn RD	anon	Pfam-B_001532 (release 23.0)	Family	MSP1a is part of the A.marginale major surface protein 1 (MSP1) complex and exists as a heterodimer with MSP1b. The complex has adhesive functions in bovine erythrocytes invasion [1].	21.30	21.30	21.30	23.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.44	0.71	-4.38	3	306	2009-09-10 23:09:43	2008-09-17 11:25:55	3	4	4	0	1	364	0	102.80	79	77.43	CHANGED	MS.EYVSSQPADSSSAGGQQQESSVSSQSDQASTSSQLGsDSSSAuGQQQESSV.SQSDQASTSSQLGsDSSSAuGQQQESSV.SQSsQASTSSQLGTDWRQEh+SsVASVEYhLAARALISVGVYAAQupIApSpGCASLSVAEVEEI	............................sDSSSAuGQQQESSV.SQSsQASTSSQLG..sDSSSAuGQQQESSV.SQSsQASTSSQLG..sDSSSASGQQQESSV.SQSsQASTSSQLGs.D............................................................	0	0	0	1
+11503	PF11671	Apis_Csd		Complementary sex determiner protein	Pollington J	anon	Pfam-B_4678 (release 23.0)	Family	This family of proteins represents the complementary sex determiner in the honeybee. In the honeybee, the mechanism of sex determination depends on the csd gene which produces an SR-type protein. Males are homozygous while females are homozygous for the csd gene. Heterozygosity generates an active protein which initiates female development [2].	25.00	25.00	28.30	27.90	22.10	22.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.21	0.71	-4.40	5	496	2009-01-15 18:05:59	2008-09-17 11:44:59	3	6	18	0	8	464	0	126.60	68	61.76	CHANGED	TSRKRYSRSREREQKSYKNENSYREYRETSRERSRsRptRERSRE+KIISS.ss..NNYNYNNNYNN.N..pYNKh...........YYNINYIEQ..IPVPVYYGNFPPRPIMVRPWVsMQEQVPRFRYIGPLTPFPPRFIPPNtYR.RPPLNPRFRPMY	............TSRKRYSRSREREQKSYKNENSYRc.YRETS+ERSRDR.pERERS+E.+.....I....SShs.......s.......p..h....N...................N........h...p..N....s.....Y......Np.....p............p.ph................YY.N..IN.Y...IEQ......IP..V....P....l...YYG.NFPPcPh..tPWls.M.QcQlP...R.FR.a...IGP..T.sF.PRFIPP.NhYR..RP.P.LNPR..FtPh.........	0	2	2	8
+11504	PF11672	DUF3268		Protein of unknown function (DUF3268)	Pollington J	anon	Pfam-B_4693 (release 23.0)	Family	This family of proteins has no known function.	24.70	24.70	26.00	25.70	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.39	0.72	-3.94	13	115	2009-01-15 18:05:59	2008-09-17 12:50:20	3	2	104	0	24	97	7	101.90	37	68.03	CHANGED	tPlpCPYCuupspLsssphlYG.+phsshPhl.....YlC..ss...CcAYVGsHP......tTshPLGTLADtshRptRppAHcsF-pIWc..sppho.RocAYtWLApcLsl.s.ccsHlG	.......hCsYCGu.tuhL.sp.u....sth.Ys.hp.s..p...s..h.....alCss...CsAalGsHs.......ps..c..hPLGpLAsspLRpt+ppsH.tsh-slhp...............ss...thp...RscuYpWL...A...ppLGl.sht.sHhG..............................	0	4	10	18
+11505	PF11673	DUF3269		Protein of unknown function (DUF3269)	Pollington J	anon	Pfam-B_4706 (release 23.0)	Family	This family of proteins has no known function.	25.00	25.00	25.70	25.40	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.40	0.72	-3.54	3	181	2009-01-15 18:05:59	2008-09-17 13:34:48	3	1	153	0	5	62	0	72.80	80	98.93	CHANGED	Ms.hEKYYLYRsDGTE-IKVtKcKDNVNsV+oLTGAHFS-EcKhMTDS-LK+FKAsHGLLYEEELGLQuTIFDI	....MP.KEKYYLYREDGTEDIKVIKYKDNsNEVYSLTGAHFSDE.KKIMTDSDLKRFKGAHGLLYEQELGLQATIFDI....	0	2	2	5
+11506	PF11674	DUF3270		Protein of unknown function (DUF3270)	Pollington J	anon	Pfam-B_4714 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Streptococcus.	25.00	25.00	25.70	25.60	23.70	21.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.14	0.72	-3.97	8	347	2009-01-15 18:05:59	2008-09-17 13:38:56	3	1	344	0	25	115	0	89.60	53	94.35	CHANGED	hsL++hpsa.c..DhpYQc...cphPcYQ-aQshsppss..KLcELlFFupIAsFClhTVLhoFlhLuhpLsohaAFslAhslS....LulhpshcphIK+	.............MPVRKLQS..Y.....Es-YQE...ppQhP+YQsYsPEApocA..sLKElLFFlNIAVF.CIshslFSFIFLALKLuTsLAFshAIuhS....LllLpltRslIK+.......	0	2	6	15
+11507	PF11675	DUF3271		Protein of unknown function (DUF3271)	Pollington J	anon	Pfam-B_4697 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Plasmodium.	20.40	20.40	20.60	21.50	19.50	19.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.75	0.70	-5.25	12	39	2009-09-10 14:53:48	2008-09-17 13:49:26	3	1	5	0	39	40	2	169.30	39	85.08	CHANGED	NIILSFFILVIFSNVK....AATFQDs.NsssPKsIuYsSVuQPhssFs+pccpHspYLDlINslh+DpScNhKYAYpGuNYHWlITDFDISIDNSSptLK+phScKtpEuLhhGosYFIuYIKDpIKaLlSpaMHKYDFEpNYtssLphLucDLKsLIYDcF-pchKpDLIKYEstPEscKh+cpAKchhcsLVpNSuhplpGYFIKlpcDusYhcLscspslYFsIsIsKs.uphsathKh.cs-lsEhlss	................NIIlSaFILsl.sNV+....uAoFQst.Nssps.........p.IuY.slspPhshhph.cppahpaLshINphhpcpscs.h.cYsapsssaHalITcFcl.IsNus..lpthh.ppt.p.h..us...h.hh...h.......h.pYsF.....t....h.ppLKs.h.spF..ph...hlp.p....p...................h.hps........................................................................................................	1	0	6	38
+11508	PF11676	DUF3272		Protein of unknown function (DUF3272)	Pollington J	anon	Pfam-B_4726 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Streptococcus.	25.00	25.00	41.60	41.50	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.78	0.72	-3.96	7	324	2009-01-15 18:05:59	2008-09-17 14:07:26	3	1	321	0	18	94	0	56.30	61	95.59	CHANGED	shpQFlhhAlhTshETYFFNtSlhoGpahhAhFauhLLhRslphsYhls+hsctl.K.....p+K	..hpQFlhhAlhTAhETYFFN-uhMTGRYIMAAFWAILLFRNFRVSYVMGKIVDlIDQ...chs+K..........	0	2	5	9
+11509	PF11677	DUF3273		Protein of unknown function (DUF3273)	Pollington J	anon	Pfam-B_4727 (release 23.0)	Family	Some members in this family of proteins are annotated as multi-transmembrane proteins however this cannot be confirmed. Currently this family has no known function.	25.00	25.00	25.40	25.20	20.10	19.90	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.80	0.70	-5.13	9	59	2009-01-15 18:05:59	2008-09-17 14:11:00	3	2	17	0	51	59	0	236.90	35	81.42	CHANGED	ssEsspsRGPpapPhhsFF.sh.LRhGFhlQhluhh.LhhluhashGt..huIhsF.LpAhPE...phussha.hlhhhhuhaLlGTLhIh.FplhssDDo..KtsRGaRAGoKhLttAoolshlShhLphVpa..lhusaahstpWhschttstusWlhahhupllsuFuLhlYGuuhFaLEsYHsEGTuEphuWlshhhFhhAGlsElL..hsFhssGshhoLhhL......lulhsuolWAhhFEPlhc+asspLpposlpN-.....hhKscpshuY	.........................sps.psRG.ph.PhhsaF......ssh.LRhGhhlQhhuhh.hhhh.hhshGs..hulhsF.Lpuhs-...phupuhhhhhhhhhuhallGslhlhsFQ.hlsDDo...p.sRGaRuGoKhLphAshlshluhhLphl.a..hhs.hahstpWhtchttstSpWhhahhuplhcuhuLhhYGhuhFhlEsYHsEGsuEtauahshhhFthuGlsElh..hhFhshush.sLhhh......huLhssslWAhhFEPlhp+hsspLpppslps-.....h.+.pph..Y............	0	17	27	43
+11510	PF11678	DUF3274		Protein of unknown function (DUF3274)	Pollington J	anon	Pfam-B_4733 (release 23.0)	Family	This bacterial family of proteins has no known function.	21.00	21.00	21.00	21.10	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.94	0.70	-5.19	10	137	2009-01-15 18:05:59	2008-09-17 14:28:57	3	5	81	0	29	183	0	241.10	28	36.78	CHANGED	sohPAMssLtshRFaQRMWT+RpRsG......csVtVG..sPPtphsLRtcsEs+YPGuGss...........sshhupuslsps-pRhINGEsLpPPacPcM.asGEs........tphsGsso...........tuG....hDsPDDVstslALGNstAch+hhtlssp....ssstchppsctp...tuaN.pG+s.sDQTpsaRssssss.s............sthllhRcETPsEsRtRMppsscuhp-NSYHSulL+SsENHRWVTAMDVAIGQAcoLDDPsWRclLlAhADW+h........stcphcphp-Lss......ap+LStcsQcLlcAospYYcpGsFPupp	..............................................................................................................................................t..h.sh..L...tFaQRhaThh.R.t.........hlG...sst...hh...p.hh.ssth............hshh.pssh...p.hhlsu.tL..shtsph..tGp...........h.Gpss...........huG....h.t.Dshshshulus..h..p.....h..t......................t...h.t.tht.....hN...t...tppo...hph...tt...................thhhlpRpcT.Pp..EsRtphtp..s.ssthttsoaHSull..pssEspRhVsAhDlAIGpup.olDDs..s.ahphLhthADW+h..............s.t......p..t........at.t.p..tsp.hhpts..Yh.pG.hP...t........................................	1	3	12	18
+11511	PF11679	DUF3275		Protein of unknown function (DUF3275)	Pollington J	anon	Pfam-B_4743 (release 23.0)	Family	This family of proteins with unknown function appear to be restricted to Proteobacteria.	25.00	25.00	58.10	33.20	19.80	22.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.49	0.70	-4.70	5	108	2009-01-15 18:05:59	2008-09-17 14:35:44	3	2	82	0	33	99	2	189.60	49	92.06	CHANGED	IsLPG.pLslRTIs.GRNG-FsVG+LtTsIGEFcVKDALLDQacEGKY+G-FVIocIaP+pYsuGG+hVsEIRApLDuMsLDuhspLScD-scchussEsDPLDE.Ptl.usossuSAPsPuPSPpsspPuSpRAo+D.h.chuPFGhcs.SsPAppsspASssc-sDA.......ELFGslWP...lGEsVKLDoTVDR+pLRpQssRLGpLG.YcLDF+pQhWshc	.........IslPG.pLslRTIp.GRNGsFsVGRLuTsIGpFslKDs.L-QY.EGKYcG-FlIppIhPpsYss.GGthhhEIRApLDuMTLsslDpLScDEA.cph.usp-lD...PLDE.....t..t.ssssuts..ttsp...t........tss.pussD.....sPFGhss.stPstts..s.ss..p-sDA...................tLFG.hlWP....LG-sVKLDoTlD.R+...tLRtQhsRLGp.LG.YthDhppQpWph.p...........................	0	4	20	28
+11512	PF11680	DUF3276		Protein of unknown function (DUF3276)	Pollington J	anon	Pfam-B_4744 (release 23.0)	Family	This bacterial family of proteins has no known function.	22.20	22.20	22.20	23.90	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.66	0.71	-4.32	27	215	2009-01-15 18:05:59	2008-09-17 14:53:19	3	1	206	6	67	189	126	117.10	36	92.57	CHANGED	M..p-pc.h......-pE-lFS.Ksl+AG+RTYFFDV+uT+usDYYLTITESKKhspcDG...phpacKHKIaLYKEDFppFtEsLp-hhsaIhpcph.....p-Vho-capcs.pccppp.tt...pt...........spthpDlsF	..........................t......-+--lFS.Ksl+AG+.RTYFFDVKcsRt.sDhaLsITESKKhs...ss-G.....pF-KHKIFLYKEDFpcFhpsLp-slsa.Ipppph.....pcshpcp.tpps.pcpt..t..................................................................	0	32	60	65
+11513	PF11681	DUF3277		Protein of unknown function (DUF3277)	Pollington J	anon	Pfam-B_4749 (release 23.0)	Family	This family of proteins represents a putative bacteriophage protein. No function is currently known.	25.00	25.00	25.10	25.10	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.80	0.71	-4.71	7	159	2009-01-15 18:05:59	2008-09-17 15:46:29	3	1	142	0	23	117	4	138.20	38	96.58	CHANGED	Mu.TYSFhDVoASlsGPsGuhsLGYGsAsAEEGIslAhussKNTMTlGADGEsMHSLHADKSGpITlpLLKTSPhNpKLMAhYsAQSlsStLWGpNlIslpppsuGDlssuRusAFpKtPDhp.AKDGshlpWVFDssKIDphLGoa	......................................shthsh.ts..h...l.s.Gtusu-p.sIslshsuspsTMTlGADGEVh+SlpADKSGTlTlsLLpTS...PsNppLSh.hYNs.Q.p.t.Ss.s.saGs.sslsI+spsuuDlh.TApsstFpK.PD.stupsusshsW..sFcshclD...........................................................	0	1	9	16
+11514	PF11682	DUF3279		Protein of unknown function (DUF3279)	Pollington J	anon	Pfam-B_4753 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Enterobacteriaceae.	25.00	25.00	26.60	25.90	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.57	4	650	2009-01-15 18:05:59	2008-09-17 17:06:46	3	1	218	0	13	267	1	116.50	50	91.63	CHANGED	phlKsaLA.sups+hlsAcpAtptshtchhC.hSCGssLpLp.tsDsQ.sWFEHDphslsE+thtpCsalcPEc+E.phl.+LpphshsshslscstpWaCVhCppcY.GcKhCsuCtTGlYShssspp	.........................hhhpsahA.DupG+hssA+pAtpt..shpchhC.h.CGssL....php.thDsp.PWFEHsp....sl.sE.+t..pCsalcPtc+Ehphl.....+LQphsss.shPVs...+htpWaCh.CccDY.G.E...+hCs+CtTGhaScths....................	0	0	1	4
+11515	PF11683	DUF3278		Protein of unknown function (DUF3278)	Pollington J	anon	Pfam-B_4766 (release 23.0)	Family	This bacterial family of proteins has no known function.	24.40	24.40	24.90	25.00	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.74	0.71	-4.15	9	428	2009-09-10 23:48:43	2008-09-17 17:07:30	3	2	313	0	30	252	1	124.50	34	72.54	CHANGED	MK.KEThs-KlIKpFYGIoGPLDEaKRppss+lGNpsFIhLahhhlhuslluhhLutpaPp..lAhhh...shlhlhshhsusYlhaps++ptlsslEl-htsp.ptp+phhhtulKhGlaaslhhahlhsL	................MK..KEshopKLI.K+hYGIsGPLDEa++pEs.s+lGNpsFIhLFalhhhusLIsLl..L...uh..ca...sp..plAhhYs...llhllsh.lh..usYl.s.hph.+.+ptl...st...hE.....p...h...h.s.t.....Kpp+.p....h....+....h.....u.lphGlhaulhhahh...h...............................	0	2	12	17
+11516	PF11684	DUF3280		Protein of unknown function (DUF2380)	Pollington J	anon	Pfam-B_4754 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	27.70	27.70	29.30	34.20	26.20	27.60	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.39	0.71	-3.98	26	121	2009-01-15 18:05:59	2008-09-18 09:19:21	3	3	79	0	53	129	9	129.80	30	79.71	CHANGED	s..tplAlFshphlDoSspssh.Gspss-tuRLshlsctlRctlsppGtapllDluPss...tpls+hsshtpCsGCctchApcLGA-hulsGpVQKVSNLILshNlhl+Ds.coGchlputsVDIRGNTD-SWpRGhpYl...l+splh	................plAlhshphhDsotpst...s.pss-ttRLthhpstl+ptlsppG.apl..lsh.s.sht...tthtp.......s.....s....htpCsuCthphAcphGA-hslsGhVpKlSsLIlslslhltDs....coGchltstss-lRusoD-oWpRuhpal...lcp.h..........................	0	15	30	36
+11517	PF11685	DUF3281		Protein of unknown function (DUF3281)	Pollington J	anon	Pfam-B_4757 (release 23.0)	Family	This family of bacterial proteins has no known function.	21.10	21.10	25.00	23.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.81	0.70	-5.22	6	95	2009-01-15 18:05:59	2008-09-18 09:36:49	3	3	24	0	4	63	1	178.40	40	67.00	CHANGED	KKKlLIGuslISSssLLuSCGKoETAsELRIVDpCNssNDLCcFELsDAlVSRYTNlLGKTIERVESQTPL+..cIpGTITWNsPAGAoLADNo-VpTcLGsuCQsDsCTANSNPTAYNLssGoNoISVSGhVTVsGKplDLAo-V.PslIDTttVtsS.HVFPTGsLPsGLTLpsLVssLNhsSc.....sAHGTFSusGSNL+ITCsoGYEWLDstsPsYG.phThucssRuVAhspW.p.....-psshhstptDshs.hTpNG.hsss..sshsWpAGCWs	.........................................KcKlLIuhsllSusslLtuCuKoETsp-LRIV.pCsss......pD..........hCchEhsss.sppYss.LsKpl.h.psppslp..tlptolpW...tsuphhs.ssl.sphs..tCpsssCssstNPsAaph...Gpp.lo..V.GphTVssK.......phslspph...s.sh..h..o..hhF.................................................................................................................................................................	0	4	4	4
+11518	PF11686	DUF3283		Protein of unknown function (DUF3283)	Pollington J	anon	Pfam-B_4778 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	26.00	35.80	24.90	24.30	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.77	0.72	-4.17	10	120	2009-01-15 18:05:59	2008-09-18 09:52:53	3	1	119	0	13	56	3	60.80	64	84.46	CHANGED	NLSLLPssEKN+IELDKQASFhVW+lKpAKsGPEsItcphpKlsDssE+saFcQulEKYK+	NLuLLsAsEKN+lELDKQASaLVW+LKpAKuGPEcIscQhuKIusEuEKpWFQQSlEKYKR.	0	1	4	9
+11519	PF11687	DUF3284		Domain of unknown function (DUF3284)	Pollington J	anon	Pfam-B_4781 (release 23.0)	Domain	This family of proteins with unknown function appears to be restricted to Firmicutes.	23.70	23.70	24.80	24.20	23.50	22.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.34	0.71	-4.37	15	343	2012-10-02 19:24:03	2008-09-18 10:54:25	3	1	293	0	39	178	1	119.40	28	84.05	CHANGED	M.cIspp...LshsscchFsplhpSshhDlcptTG+clthtpL.sGhsYpKpasstt....puplc..IT..chttsphYphpTsos+ssapscYplpsls-spoclpasEphpspshhtphNshlsshlhuh	.................................................McIspp...LplsucphasplhpSllhDl+psTG+p.l.ph.cpL.pGapY..hKph....up.st.....puplc....Is..chhtsphYphphsoscsp.hslpYplps.l.s-s.p.sclpYsEphpshs..hhp+hNshlhuhhhs.....................	0	11	25	28
+11520	PF11688	DUF3285		Protein of unknown function (DUF3285)	Pollington J	anon	Pfam-B_4791 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	82.00	81.70	19.20	17.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.12	0.72	-4.34	13	68	2009-01-15 18:05:59	2008-09-18 11:37:32	3	1	68	0	29	68	90	45.00	62	71.33	CHANGED	ssPsPSaVKLAMRNMVRKGupSLhHFuLTslGLLGhllhlAaLsR	...pPsPSaVKLAMRNMVRKGupSLhHFsLTslGLLGhLlslAaLsR.	0	5	19	27
+11522	PF11690	DUF3287		Protein of unknown function (DUF3287)	Pollington J	anon	Pfam-B_4801 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	27.00	27.00	27.70	27.70	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.42	0.71	-4.00	15	46	2009-01-15 18:05:59	2008-09-18 12:48:28	3	5	6	0	16	44	0	106.90	28	35.22	CHANGED	sp-h.s............t.........sPtah.sscsFpPu.........sVhhPpslh...phssc-+ccshsFhcpVtspH+chscc+pcLthKhQsl......hERch+tLEScPtcW.chshsplAcIPchLh.alctpspss	......................ps.sss.............ss.a..sscsF.Pu.........slhhPpshh...phssc-pccshsFhcplsspH+chpcc+pcLthKhppl.......ERch+tLEucPhpW.hhshsphA.lP..hh.hh..tst.s...................	0	15	15	15
+11523	PF11691	DUF3288		Protein of unknown function (DUF3288)	Pollington J	anon	Pfam-B_4815 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Cyanobacteria.	25.00	25.00	28.00	37.00	22.50	16.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.11	0.72	-4.25	18	73	2009-01-15 18:05:59	2008-09-18 13:06:01	3	1	73	0	29	74	110	93.60	43	93.36	CHANGED	p-QsHPhappDRphVDpLLsps..P....s-.sLsELARLhIRYcsFPGAcDlppDL-+lLppWpLoc-cLap+TRplaucG............tVhsutssp-p-Dh	....-QpHP.appDRshVDpLLspc....P....s-hsLs-LARLhIRYpsFPGAc-IQpDL-+lLppWpL.Tc-cLFpKTRpIaupG............tVapstss.p-pps............	0	5	19	27
+11524	PF11692	DUF3289		Protein of unknown function (DUF3289)	Pollington J	anon	Pfam-B_4824 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Proteobacteria.	25.00	25.00	38.70	29.90	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.97	0.70	-5.13	6	334	2009-01-15 18:05:59	2008-09-18 16:00:26	3	6	270	0	35	192	3	246.80	54	93.64	CHANGED	Muss.......LuFPhslFpTQ++hNDYuADDM+sGDLo-ppLppsFsLpcVSs+lD......PY...pLp+hssFs..p.pah....st+hchlT+pcCscILFDEhRshShsFShaGsY+pLIs+hIsHMQpssGusFpDhpLspAh+-hIhsDpopsSolttIKpIlsctlDacptlaP.phpsphthsls+.shLPKFsRhpDpFNGLGIoVHDlaATpIoIcSLplppcpYpAlV+YpsQDHFGLDcpDI.ph+F+sFpFFRlWFVLQRaNcFGaKPFMTNMcAslpIsGs	........................................................h.s...........lshPCTLFETlshFDDaSADDMQYGDMsEpDF.LSLGLSDISAKVDPY...RLIK.Y.c..h....uP...s.shuh.....ssoSGsKISppECsDILFuEMK-LAK.MF.SFF.G...pYKoLIc-LI-HFRYG....NG.ssF+.Sp.................pLNhu.F+E...+Ipp..h....s.h.N.......S..slp....lIK....csI.-ss.I...sps.s.s.....h.Y..p......s...h....hhpp..I+......s.pLL.....u....SRL.......sKF........N.......cF.cDs.FNGLGISVHDIsAp+IoLhShQ.h........Y......s.h.uao.ATlHFhuQDHFGLDsTDI....KN......ph......Ys.+a....RF.FRIWFhLQRa+c..F..A.........FKPFhTNhpsh......ct.........................	0	10	16	23
+11525	PF11693	DUF2990		Protein of unknown function (DUF2990)	Pollington J	anon	Pfam-B_4826 (release 23.0)	Family	This family of proteins represents a fungal protein with unknown function.	21.10	21.10	21.40	22.00	20.70	21.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.96	0.72	-4.11	6	16	2009-09-10 22:19:26	2008-09-18 16:02:46	3	2	16	0	12	19	0	63.40	49	26.64	CHANGED	lusLsAsShAAPshFDNhYDYSDDLAEFLGRVSKaI-su.KDlhsuosTCDTSpIALPAaASGLP	..usLsAsuhAAPs..hF-slYDaSs-LAEFhu+VSKaI-su.+-lhs..uosoCDsSKIuLPuaASGLP....	0	1	3	9
+11526	PF11694	DUF3290		Protein of unknown function (DUF3290)	Pollington J	anon	Pfam-B_4838 (release 23.0)	Family	This family of proteins with unknown function appears to be restricted to Firmicutes.	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.74	0.71	-4.47	10	692	2009-01-15 18:05:59	2008-09-18 16:08:16	3	2	519	0	48	304	4	107.30	33	97.65	CHANGED	sFYoYsYlpoQtsppsahthlLhllhllshlhFshhYlRc+hsTKYRDLuIIulLhLlLhlGIQIssapsspsscsQspphlsFIcsVAcDhsVccs-VaVNoouhsDGhIV+Is...sphYplshss-sssYhLpKscLhs....chV.VcK	..........pFYshpYl.sp.s..pshlhhhhhhhhlhhhhhhhhhhhpt..pht.caR-l.hh..h..h..hhhphppap..pstpsp....pt.htFlc...lupp.tVs.pplhlNoot.t-G.hll+ls...p.aYch..ss-.p..pYhLpch.Lhp..p.lchl....................................................	2	11	24	31
+11527	PF11695	DUF3291		Domain of unknown function (DUF3291)	Pollington J	anon	Pfam-B_4872 (release 23.0)	Domain	This bacterial family of proteins has no known function.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.99	0.71	-4.76	34	150	2012-10-02 00:20:33	2008-09-18 16:51:27	3	2	130	0	59	154	71	131.50	34	84.44	CHANGED	LAQlNlu+.ltu.shDsPpls-FhssL-plNuLA-puPGFVWRhp...s-susu...T.shpshsDPt.....hllNhSVW-sl-uLpsFlacoh.Htphh+RR+EWF.cphscsphVLWWV.PsGHp.PolsEAhcRLpaL+ppGsostAFsa+psa	....................................LAplNluh.hht.Ph-s..P.....ht-FhssLs.lNuhA-pusGFlWRhp...s-.s.ssu.........sslphh.s-st.....................hlsNhSVWcsh-uLpsFsapsh.Htphh+..R+p-WF.pph..t.csthshWWV.ssGch.P.ohpEAhpRLphLcppGsoshAFsapp..........................................	0	17	43	53
+11528	PF11696	DUF3292		Protein of unknown function (DUF3292)	Pollington J	anon	Pfam-B_4874 (release 23.0)	Family	This eukaryotic family of proteins has no known function.	23.70	23.70	24.70	23.70	22.30	23.60	hmmbuild  -o /dev/null HMM SEED	642	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.75	0.70	-6.65	8	115	2009-01-15 18:05:59	2008-09-18 16:53:43	3	4	60	0	98	119	2	426.50	31	86.56	CHANGED	GPTDSHsLSQl-s.-E..KGLAQKAGsos..cVoDlGWs.pSDpl-EclVsGLSNEDLWMLIRRFNKQIYaVKAVP-uPLQcLDLNRAEDEpFSPDKLRATLERFYTTVlVGLTsFhKHIARLRSWREPcRTssFCu......VYFlAWLLDhLlPTIFGhLlsLVlaPsoRpaLFPPAPlALVD..osTGGVQKPKAGVLGSHDSlTGAPEKYKGEAAEQEASNLlsSlAoVAVGSAAGKHDQGsP-s.....APMEuSVPDAhDlsu+uADAQuAAtG-sPs-sHDKTRcPMKcTVhNuANpuMRVlSDIsDsaERFuNALSPTPPFsusTPpLRLuGlLuuGhLsSLlTSSYVFlKhuTFhlGhuFFGDPllQRslsYLN+caPpWp+LL-LQNoLLKGVPTNAQLTLTLLRIGEuNuAPLPPPPSS.......SL+KsPopPAolsccplsL.sASppEIspAAAP-Ppsssscpcppsc..K...KKshGuRlluFF+GTTATGIEoKLAlDRsRAtAGSpHAKN+lGlL++KGccTL.PhGPlcFDARYKGKRGsVVIDSSpcPPlLYFTTD.oshLsDhRLEsRKKGoVLFsIPVTDIpEhRKIGGLGWKGKLlsGWAVG.oKEVVDGLVIsG.ccscQpYQLTAMpsRNpLFNRLVAIDGQVWESa	.................................t....................................................................hh.sh.sp...ph........a.h...................s.tthDh..up..ppphs..spplRuplERhYhslh.thhthh..pclhRLhoW..p..-..RTthhhh...................sY.huWhhshlhshh.hhhhhLl.h.s...R.hhFPsss.uhhs....psu.shtps.ts.huspsshT..Gus..cphc.GEusEp...EA...pshltuh.sslsh......tshs.up..s.....t.s.....t.........................t...tt....t......t.............................................tscsc..h.........tth.........h.t.th.t..hphhtth.D.hE+hus.................hh.....................a..........h.h....hh...hh.h..hhhs..hhh+..shhhGhshFG.pPll.......hhthlsp.hspWpp.h.....hphpp..o....l.h+GlPTsuQLslTLLRlGEhstsPlP.sPP..............................................................t..t..........................s.tt.....httt.t.........t................t......t...............................t.t...phhthh+t.s..htts..hpsththsphht..h.s.....t........s+p.hluhl...................t..............................................GPhp.......F.s+hptppGhhhlst..t....t............s...l.a...............stt....................................................ts................aphslt-l.phpKht......G...hGh.pt+hh...sths...tp.......chhDGh.l.....p..tpth.......hsuh..RptlFNRLhuhst.ph.Wp..........................................	0	30	49	83
+11529	PF11697	DUF3293		Protein of unknown function (DUF3293)	Pollington J	anon	Pfam-B_4879 (release 23.0)	Family	This bacterial family of proteins has no known function.	25.00	25.00	26.50	25.30	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.37	0.72	-3.86	40	218	2009-01-15 18:05:59	2008-09-18 16:58:22	3	6	213	0	70	177	62	70.30	36	47.65	CHANGED	ITAaNPhS.phhosppNphtsppLtpcL...tphshshh..sshG....tssst...sW.hEcSahl.slshp....pAhpLGpcFpQNAI	.....ITAaNPtS.....phlSsp-NphpsppLtppL...hph.shs..hh..ps.s........sssph...pW.hEcSasV.s..hshs.......pAhpLupcFsQNAI....................	0	17	37	57
+11530	PF11698	V-ATPase_H_C		V-ATPase subunit H	Mifsud W	anon	Pfam-B_2481 (release 6.5)	Family	The yeast Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex responsible for acidifying organelles. It functions as an ATP dependent proton pump that transports protons across a lipid bilayer.  This domain corresponds to the C terminal domain of the H subunit of V-ATPase.  The N-terminal domain is required for the activation of the complex whereas the C-terminal domain is required for coupling ATP hydrolysis to proton translocation [3].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.44	0.71	-4.18	34	388	2012-10-11 20:01:02	2008-09-24 15:29:57	3	8	307	1	258	379	5	116.70	42	25.79	CHANGED	+phooFDcYhuElpSGpLcW.SPsHps........ppFWpENsp+h.c-ssacll+pLsclL..............ppop..DshsLAVACpDlGchl+h.aPpG+sll...pphssKtclMpLhsc..sDppV+hpALhulQ+lhspsWc	................t.pLooFDEYssElpS.G+L.cW..SPsH+s........ppF..W+ENAt+h..p-csacll+hLsclL................psSp....DsplL.A..V.As..aDlGcaV+..............p.....a.Pc.G..+pll...-pLG...uKphVMpLhs..c..c..DppVRapALhAlQ+lhhpsap.........................	0	97	150	216
+11531	PF11699	CENP-C_C	Mif2;	Mif2/CENP-C like	Mistry J, Wood V	anon	Manual	Domain	CENP-C_C is a C-terminal family of fungal and eukaryote proteins necessary for centromere formation. CENP-C is the inner-kinetochore centromere (CEN) binding protein.  In the budding-yeast, Mif2, the yeast homologue, binds in the CDEIII region of the centromere, and has been shown to recruit a substantial subset of all inner and outer kinetochore proteins [1]. Mif2 adopts a cupin fold and is extremely similar both in polypeptide chain conformation and in dimer geometry to the dimerisation domain of a bacterial transcription factor [1]. The Mif2 dimer appears to be part of an enhanceosome-like structure that nucleates kinetochore assembly in budding yeast [1]. This C-terminal domain is the region via which CENP-C localises to centromeres throughout the cell cycle 2,3].	29.00	29.00	29.00	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.83	0.72	-4.00	11	190	2012-10-10 13:59:34	2008-09-25 10:52:40	3	10	165	2	133	209	11	84.50	36	12.58	CHANGED	F+htKhhsp.s.FhuoGhlcLPs.uu.KpspsS+csphlFaVhpGtlpVolpcspFhhupGshFQVPpGNpYsltNht.sc-ApLFFsQ	..................h+htKhhsp.s.FhuuG.hlcLPP.sutKp.ps.oppsp.h.lFaVhpGplpVTl.........pc.....spFh.lspGshF.VPp.GN...hYslpNhh.spputlaFsQ.............	0	37	73	106
+11532	PF11700	ATG22		Vacuole effluxer Atg22 like	Wood V, Mistry J	anon	Pfam-B_14077 (release 22.0)	Family	Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy [1].  This family also includes other transporter proteins.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	477	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.52	0.70	-6.02	50	1392	2012-10-03 03:33:39	2008-09-25 16:14:42	3	4	1200	0	527	2826	2253	417.40	25	93.84	CHANGED	so++ElhuWYhYsauspsaslsshuoalPhhlpphucp.tGh.hssp..sC.........................................................tsspCllhhhG..hplsssSashYshulSshlQullhlsluuhAD.....ausaRKplLlsFuhlGuhsshhahhl.ssppa....hluulLhllus.ssa....us.shVhhNSaLPhLscspsphptttt..............................................tt.......t..t..h........................................................oplSuhGhulGaluullltllslhllhshpss...........shsl......plslhlsGhWWhlaolPshhhL+s+su.......................tthpshhsh..lhhua+pLhpsh..+psppL+pshlFLsuWFlluDulsTlsususlaupspLshssss.....LshlsllshhsuslGuhhas.hlsc+hslpsp.........psllshlhhhtllslaG........hlGhh.t......hhGhppsWE...........hashushYGlshGulpShsRShaupllP......GpE..utFFuLauls-KuSShlGPhllGhIhDtT..G...................slRsu..........FhFLslLhllslslh.hhlsl-+G+c-ut	...........................................................................................................................................................................................t......huWhhaDauspsa.shhl.h.o.h.h...h.shah.t.s.h.s.......................................................................................................s.....h.ps.s.u..hh...a.shu....luslllul.luPllGshAD..........ht.uh.++...h...hl.h..h...h....s...h.l..s...s..h...ss..h.h...h.....h....hl.....s..ssth...................hhsl..sl...h....h..l..u....t...luh........ss..u.l..hYs....uh.L..splsssc..ph........................................................................................................................................................................................s+lSuh.Ga.uhGY...l.Gu.hls.....h.l..l.s..l.h...h.h.h.t.spts.............................t.shs.h..............R.ls.h.hh.sAlWa...h.l..F.s.lPh..hh..hl..cp.t..........................................................................................h.t.h.tph.....lt.tu.a.p...c...L.....h...p.......o.....l.......p..p...l..p....c...h..+..s........l....h...h....F..L..l.A...h..hh...a..p..DGl...s...s....l..hs....hu.s.ha.u.t.........t..t..h..........G.hs...ssp...............lll.h...h.l.l.s...p....l..s..A...h......h.uul....l...hG....hl.sc...+.h.Gs..+................ph.l....h..h...s.l....h..hh..h.h.l.s..h.h....u..............h.h..............................h.p..s.s.ht.....................F.a.l.h.u..h...l...l....G.h.h........h..G..s...h.Q...u...h...S...R...Shhu...cl.hP..........spp.......upaFGh.Ys.ls.G..Ks.suhlGPhl..h...uhh.sp..ho.....G.............................s.h..p.....h.u....................hh..s...l..h.l..l.h.l..l..Ghhlh...hhl...........t................................................................................................................................	0	195	351	455
+11533	PF11701	UNC45-central		Myosin-binding striated muscle assembly central	Wood V, Coggill P	anon	manual	Family	The UNC-45 or small muscle protein 1 of C.elegans is expressed in two forms from different genomic positions in mammals, as a general tissue protein UNC-45a and a specific form Unc-45b expressed only in striated and skeletal muscle. All members carry up to three amino-terminal tetratricopeptide repeat (TPR) domains towards their N-terminal, a UCS domain at the C-terminal that contains a number of Arm repeats Pfam:PF00514 and this central region of approximately 400 residues. Both the general form and the muscle form of UNC-45 function in myotube formation through cell fusion. Myofibril formation requires both GC and SM UNC-45, consistent with the fact that the cytoskeleton is necessary for the development and maintenance of organised myofibrils [1]. The S. pombe Rng3p, is crucial for cell shape, normal actin cytoskeleton, and contractile ring assembly, and is essential for assembly of the myosin II-containing progenitors of the contractile ring. Widespread defects in the cytoskeleton are found in null mutants of all three fungal proteins [2]. Mammalian Unc45 is found to act as a specific chaperone during the folding of myosin and the assembly of striated muscle by forming a stable complex with the general chaperone Hsp90. The exact function of this central region is not known [3].	25.00	25.00	25.10	29.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.77	0.71	-4.58	31	280	2009-01-15 18:05:59	2008-09-26 10:22:29	3	10	207	3	188	266	1	194.20	28	23.10	CHANGED	sspplcslLppLs.......................................................................................phstssRshAslhhs+h...L...csppcshpchhscalpshl.....pcsch-..................................shlhshsslsslaPsss-lsuslhhsc.....shhthlhshss............tcscphphssLELLsuAChscssRphlscphhphLcphhppspppt..........................hphhAslsLsKl	.............................................................................................................t..cplchllspLh...........................................................................................h.lssssRhhAolhls+l...................L.....-st+-p...a...pchhpcalpsph.....ppts.h-..................................splpAhpsloslh.ussDlusplhttc.....Glh.ph.llsLss............scpcp.phsslEhLhtAssctsptshIhppslslLcclhppscs-p...........................l+lhAhVuLsKL..................	0	46	82	138
+11534	PF11702	DUF3295		Protein of unknown function (DUF3295)	Wood V, Coggill P	anon	Wood V, Chahwan C	Family	This family is conserved in fungi but the function is not known.	21.40	21.40	23.90	23.90	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	507	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-12.92	0.70	-5.51	9	124	2009-09-14 14:02:36	2008-09-29 10:57:28	3	5	88	0	107	121	0	354.50	33	70.17	CHANGED	pptuuDlPELSuSV-SssS-pApchppphcp.......................Phs.th+PslhRpDSh.uShuRG+E+HlTShsLE+MVloIp..EKKsLEPLusshssluP....ht..sppspPp.ssSpoospc.s...........p.hpsoESsooousssNsS-.uu..slssusTSsouothhsp.......sSllRGF..SPS.lSoShRSpsphussPsPs.......psusshK.t..KKKtuhFTLGGSSGs-.EsSF-DRh...............shpss++poL..............Ss-hp+usssp................KKssoFccpV.sh+shp-ps.-sD.sthps---.VsESAI..-DD-DSDW.EDSlpESGpuSl--+phFQRVDS+PN.LsS..RRSLLThMhHQss+h....s.sSRSosALpRSR.ToPNGPSlsASPs-sDEtsLhM.RG...........splPRScshlh+sos.pSsuH....SPRTTRRNMLATELTESLRRpLLWERpQKuAT..ANAhLKRRHTupD.hANLppYPp......................sssscDK......Dst..ssSaN+Ys.chG.hpYHspGW	..............................................................................................t......hP..StShtS..s............................................c..h.t.............phhss.thtphh..l......pt........h.................................................................................................................................................................................................................t....p.p...hasl.GsS.ss..t.........t......................................................ott..tps...............................................h.sshtp..p............pshpt......p............p..spp-.l..s...ESAI..t...-D-....ss-W..EDShp.-SGpuSh--c..hFpRV.-S....+s..s.LsS.............R.SLlT.hhht.psp...+............s.sSpSosAl.p.s.R.....sssshssSP....c..s--...ssLhM..+u.................chP+Sps..hhshs....tthtt...........SPRTTRRNMLATELTESLRRpLLWERQQK..sss.....ss...AhhKRRHTupD.hssLppaPt..................................s.ht.tsp......p........thsphh...p...s..tYHspGW...........................................................................	0	21	50	91
+11535	PF11703	UPF0506		UPF0506	Bateman A, Ranganathan S	anon	Ranganathan S	Domain	This uncharacterised family is found in Schistosoma genomes. Although uncharacterised it appears to belong to the knottin fold. The sequence is composed of two repeats of a 6 cysteine motif.	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.82	0.72	-4.01	11	31	2012-10-01 22:06:18	2008-09-30 15:03:58	3	2	6	0	18	81	0	56.50	41	53.64	CHANGED	CRo.GQhCSRThF+RCCGNLVCQL+GaFNGsCVpCLAEt+FChhSSECCScRCRhFRCR	...........C+phGp.Cs+ThF.p+CCG.shlCpLpu.FpGpCV..p........CLstsphChpss-CCSt+Cphh+C+.......	0	17	18	18
+11536	PF11704	Folliculin		Vesicle coat protein involved in Golgi to plasma membrane transport	Wood V, Coggill P	anon	Pfam-B_3276 (release 23.0), ADDA_17305	Family	In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex [1]. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterised by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases [2].	21.10	21.10	22.40	21.40	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.94	0.71	-4.67	20	292	2009-01-15 18:05:59	2008-10-02 11:05:11	3	3	213	0	195	274	0	170.90	24	32.06	CHANGED	stsaVSopaPssspcYshLpphsh+oLSsEs..............shsusPlhFGDshcGasluhsFKlpDspARGscR+Yullllscsc........hp.LhpsWsalsptFsclIshIpppspp...tppptpppppsspps...................................sth.ss..........hhRtpshpps+SLsELTsD-tIFl+lHtahshlLpslst	....................................h...alShp.s..st.athlpp.shR........sLStEh.............................................tsscsuslhFGDs.ppG.a.shuatFplhD.pARGhpRhYullhlsscc.........t.lhppashlhsthp.c...lhpplpstsc+hh..tpppttppp.ts.p.s...........................................................t...s..............p........t.....t.........tsRsLsplssp..hahplH..hs...lL.th.s........................................................................	0	45	80	143
+11537	PF11705	RNA_pol_3_Rpc31		DNA-directed RNA polymerase III subunit Rpc31	Wood V, Coggill P	anon	Pfam-B_203281 (release 23.0)	Family	RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain [1].	28.90	28.90	28.90	28.90	27.40	28.60	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.97	0.70	-4.42	17	327	2009-01-15 18:05:59	2008-10-02 11:50:45	3	7	238	0	222	301	0	213.80	25	92.96	CHANGED	MS.......hRsuutsshs...........shsslsashs..tth..stssss.aPph.slPls..t.ssscEchhsthhhsatst.h+-uPaYTssh..t...............t.tt.............t...pcGlpRYSDKYppp++hssolcp..cP.aphchFPcELatshthsppt.pth.......s+h+pcssl.ph.......p.D.s.thphLE.Khpp..sp-.-ctpptct...........---cp-E-.D-Da....D---D..sDY.AEpYFDsG-t......DDhsD...................................tssa	....................................................................................................Mu........RGtu.tut.hsh................shptls.h.sts...t...................sh...pP.......s....slFP.........sh...hP.ls.....h.hsp.p-chhlthttphppt.h.+puPaahtst...t.....................................................................ppslcRYSc.+.Y.pt..t.p............t.....ph.ph........ps..hs..h..chhPp.ELhtphph...pp.p.t.........t.h..h....................sphttp..sh..t.............................t-....p..ch...p...t....L..EtKt..p.p...t.s.....p.-p-ptpptpp......................cccpc--...t..t---h.....-.--.p.-..tsDY.hppYFD.sG-s......D.D..-..............ts..................................	0	59	105	164
+11538	PF11706	zf-CGNR		CGNR zinc finger	Bateman A	anon	Pfam-B_19432 (release 10.0)	Domain	This family consists of a C-terminal zinc finger domain. It seems likely to be DNA-binding given the conservation of many positively charged residues. The domain is named after a highly conserved motif found in many members of the family.	20.80	20.80	21.10	20.90	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.56	0.72	-4.45	80	961	2009-01-15 18:05:59	2008-10-03 09:25:53	3	5	409	1	366	972	15	43.60	41	22.67	CHANGED	Rl+tC...ssssCshhFlDpS+sssRRWCSM.......spCGNRsKsspaRtRp	............RL+tC.....ts.ssCphhFlDpS+stpRRWCoh.......psCGNRt+sttaRsRp........	0	143	279	331
+11539	PF11707	Npa1		Ribosome 60S biogenesis N-terminal	Wood V, Coggill P	anon	Pfam-B_2493 (release 23.0)	Family	Npa1p is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits [1]. The protein partners of Npa1p include eight putative helicases as well as the novel Npa2p factor. Npa1p can also associate with a subset of H/ACA and C/D small nucleolar RNPs (snoRNPs) involved in the chemical modification of residues in the vicinity of the peptidyl transferase centre [2]. The protein has also been referred to as Urb1, and this domain at the N-terminal is one of several conserved regions along the length.	22.10	22.10	22.40	23.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.91	0.70	-5.44	42	265	2009-01-15 18:05:59	2008-10-03 11:36:46	3	8	231	0	187	273	0	302.70	22	18.51	CHANGED	sths-lhpsWshhspsss..shhshlsplLsthlthlssphp....hpphG.sl................s+hlLpp..c......hchl.h+uLsutc.............plhp..ssLcLLsplVp.suuthAcclhssh..ch..shphh.phh..pppphtp.ptt..............olRpshlcFhLuhLphs.ssth+pclLpp+ch.hsshhctlpp.DshpslhplLpslcscllp-p.sls+stKsclasphsLp+lss.LYthcsp........................slschs+chLhtlsTssphGlhhssstha.tt......................................h.ppphplpNphL.hpllp.tL+PtpsshptpL.......llpIlcssPELlusYhsch.tphp....P+hossWhuts	......................................................h....phhphaphhtt.tpp.....h.hl.thLthhlhhhssphp......ht.hu.tl....................s+hllpp.c......hchl.csLsupp...............phhp...ssLpLLsth...Vs.pusthAcplhpph..ch..shpslsphhphpctphtt....................................slRpshlpFhLuhLth.....s..ssthhpplLpp...+ph...hsshhct.lpp.Dshphlh.lLpsLcppll.............p..........s.............p.sls+..stKsphFspt..sL.pplss..LYshpst...................................................................t..tltchsHphLhtlC...o...s.p.pGlhh.ss....................................................t.tp.th.tht.NthL.hphlp...hl.+.shp...ss.hptcL.......llpIhcssP-LlssYhpph.hpht....P+ho.stWhs........................	0	56	98	151
+11540	PF11708	Slu7		Pre-mRNA splicing Prp18-interacting factor	Wood V, Coggill P	anon	Pfam-B_999 (release 23.0)	Domain	The spliceosome, an assembly of snRNAs (U1, U2, U4/U6, and U5) and proteins, catalyses the excision of introns from pre-mRNAs in two successive trans-esterification reactions. Step 2 depends upon integral spliceosome constituents such as U5 snRNA and Prp8 and non-spliceosomal proteins Prp16, Slu7, Prp18, and Prp22. ATP hydrolysis by the DEAH-box enzyme Prp16 promotes a conformational change in the spliceosome that leads to protection of the 3'ss from targeted RNase H cleavage. This change, which probably reflects binding of the 3'ss PyAG in the catalytic centre of the spliceosome, requires the ordered recruitment of Slu7, Prp18, and Prp22 to the spliceosome. There is a close functional relationship between Prp8, Prp18, and Slu7, and Prp18 interacts with Slu7, so that together they recruit Prp22 to the spliceosome. Most members of the family carry a zinc-finger of the CCHC-type upstream of this domain.	22.90	22.90	24.80	23.10	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.99	0.70	-4.61	41	344	2009-01-15 18:05:59	2008-10-03 11:54:42	3	8	276	0	246	345	2	231.90	39	50.39	CHANGED	phsaDuKRDRWsGYDsspacpVl-ca-ph-pt+cphptpp.................................sctttcpspst-ptpthhccs-h...................spppps..ssRsLRlREDTAKYLhNLcssSA.......hYDPKoRsh+-ss........t.ssthhts-sFlR.toG-....utchpchptaAWEstc+Gs...............................slclpAsPTphElhtKchppc.+....-pt+ppp+pslhcKYGspp...h.t..hp.hlspoEphhchpt.......httpths+SpatEDlhhpsHspVWGS	.......................hsaDuKRDRWNGYDs.p.-a.p.p.ll.--.Ypch-tt++ph+tpp.......................................................................................sptpt-p.spps-p.cpphs-c.-hs...........................phssppphssRNLRIR.EDsAKYLhNLDs.sSA...........hYDPKTRuM+-ss..h..............tts.sts.asu-NFhR.hoG-....shphtphQhaAWEu.c+Gs..........................................................................clHlpAsPTphEhLhKphc.c+.......-ph+pp....p+psll-KYGupc...thp.s.s.pc.....h...hl.spoEpaVEYsctGt.....................lKGt.+thspSKYtEDlhhsNHTslWGS..................................	0	88	139	206
+11541	PF11709	Mit_ribos_Mrp51		Mitochondrial ribosomal protein subunit 	Wood V, Coggill P	anon	Pfam-B_4972 (release 23.0)	Family	This family is the mitochondrial ribosomal small-subunit protein Mrp51. Its function is not entirely clear, but deletion of the MRP51 gene completely blocked mitochondrial gene expression.	21.80	21.80	22.10	21.80	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.85	0.70	-5.21	20	145	2009-01-15 18:05:59	2008-10-03 12:51:24	3	4	133	0	108	143	0	327.90	26	79.88	CHANGED	Mutt.......husLLRsSRlAplspsh.sh.psstp.............hPTHQlItT.sSShtR.u-WGLKpsLPs+hso.....palphN-lDThcclsDaEssu.saphsph+FQEhGlslsts................sppsPlFpstsspo..sppsshpshhs...........ph.hhsshosuchpchLpp....lssh+scFppaLhcptsct.................................................hsspsltchltcFLs..............................tsspphsspusschpuouGLSYs.pGpL.........psoPNGVptphlsPGRhl.....psscp.hsAlGGhVAsssss..................tsshhpthsschsRptph.aclpcAplsp.sGplhltssss	.....................................s.......p.hupLLRpSRlhtlspsh...ststtp................aPh+QsItT.sSohtR.u-WGLKpslPtK.ss...............shlpls.p.lDThEpl.T-Fcssu.spthsht+aQEhslPlshsh..................................................................................spp.pshFcsp.css...sts.shts.ht..................................................................phsh...hsshots-hpchLp+....l+ph+scFpphLhcphspp.....hp....................................................................tssttltsh.....lhcFLsh.s.................................................tsps.hs..ppssspspsouGLSY.pssth.................ppp.....psl...s+hl......hPtphh......tttpt..hhuluGhlsps..t........................t.stht..th.ssh..tttph.hps.pAplsp.pGpl.ltst.s....................................................................................................	1	29	59	91
+11542	PF11710	Git3		G protein-coupled glucose receptor regulating Gpa2	Wood V, Coggill P	anon	Pfam-B_11657 (release 23.0)	Domain	Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail [1]. This is the conserved N-terminus of these proteins, and the C-terminal conserved region is now in family Git3_C.	20.60	20.60	20.60	20.60	20.50	20.40	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.37	0.71	-4.76	19	259	2012-10-03 04:04:29	2008-10-03 13:01:14	3	4	124	0	213	414	3	195.20	24	38.37	CHANGED	sht.RlluIsuSshSlhusllulYhhhsIs.RR+.............lFRHp............LIhhLlhhDhlKAllLllYPshlLs...psssYssssFCpllGFFTAhuIEGu.................DlAIlsFAlHhulLIF+Ps............pssphEGGLY+aRhalYslsh.llPlllASLAFIs.............................tsGYpshssWCYLPscPhWYRLVLSWlPRYhIhlsIhsIYhsIYhaVp+chcpl	............................................................................................................hh.......l..shu..shu.lh.u...h..h..h.s...h...hh..h.h.h.h.....p.h.h...................haR.+...p.............................................................LIhs....Ll.lu...Dhhpulsh.l.l........sh..hhlt....ps..t..l..h..s..s...s..s..h.C.hpGahhp...hu.s....uo.................s.hhllsIAlH.T.a.lhlhps.......................ht.h....p....hh.l....as.h.sh....hl......lh..hs..s.L.s..h.ls.............................ttts..Y...s..s.s.Gs.WC..Wl..ss.....c....h...................h....h...RLh..lpal...h.alh..hhs.hl.hl.Yshl.ahhl++pht..h...................................................................................	3	53	120	185
+11543	PF11711	Tim54		Inner membrane protein import complex subunit Tim54	Wood V, Coggill P	anon	Pfam-B_3533 (release 23.0)	Family	Mitochondrial function depends on the import of hundreds of different proteins synthesised in the cytosol. Protein import is a multi-step pathway which includes the binding of precursor proteins to surface receptors, translocation of the precursor across one or both mitochondrial membranes, and folding and assembly of the imported protein inside the mitochondrion. Most precursor proteins carry amino-terminal targeting signals, called pre-sequences, and are imported into mitochondria via import complexes located in both the outer and the inner membrane (IM). The IM complex, TIM, is made up of at least two proteins which mediate translocation of proteins into the matrix by removing their signal peptide and another pair of proteins, Tim54 and Tim22, that insert the polytopic proteins, that carry internal targetting information, into the inner membrane [1].	32.50	32.50	32.70	33.40	31.70	32.00	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.24	0.70	-5.87	17	146	2009-09-10 21:07:40	2008-10-03 14:14:01	3	5	135	0	114	155	0	370.20	34	85.84	CHANGED	NPAL+hhGl.Ps....h..+LPSRNWMIFaolsuuhsuulhYD+tEp+chppKWschVc+lucEthsssp....hsRKlTVFlAsPPs.DhLcsuhchF+cYVKPlLsAAuLDY-llptcRpG-IRAtlAERIRclRRcth......................................tspst.sh-c..sppccslhshRphhGlh.....................-.ssstGslsIGRtsaKEYlpGLHEGhLGPL-.P.........................tspsttssst...pss.............tt.t.c..tssp...ptp......-s.-ccpp...........ssstP.aIsss-YssssLsPph..................P.hh.pPshslPhPpllGFLNhPh+lYRFhs+RhhA--huccsAulV.ss.hRPap.ts.................................tphhpcEEp-W.Kp............V+ptcE.........KcpEWlp............-lVhDsRlssRM+hap	....................................................................NPAh+..hhGl.Ps.......h..+LPS....RNW..hIFholsuuhsuulhYD++cp++hpp+atchVtplucEsl.ss.sp............hPRKlTValusPPu.D.t.LcsuhcaF+cYVKPlLsAuuLDaEllpuc+pG-lRstlAp+IRchR+phtt..............................................................-.....ptpp....h.phR.ph.hGlh.....................................-..hstGslslGRtsaKEYlpGlHEGh..LGPLp.P............................................................t.s.t..............................................tt.t.p........t...tp....p.tt....pt.pccpp....................p.pp.s.stP..alpsspYsst.pls.sph..............................................................P..h...pPshslshPpllGFhs.hPhRlaRF.hs+RhhA-plucpssslVhss...hRPaptsst..............................................................................................................................................................tphhp.pEEp-.W.Ks..............Vcptp-............................+pppWhp..............lshDsRlsp+Mpha............................................................................................................................	0	32	64	97
+11544	PF11712	Vma12		Endoplasmic reticulum-based factor for assembly of V-ATPase	Wood V, Coggill P	anon	Pfam-B_2410 (release 23.0)	Family	The yeast vacuolar proton-translocating ATPase (V-ATPase) is the best characterised member of the V-ATPase family. A total of thirteen genes are required for encoding the subunits of the enzyme complex itself and an additional three for providing factors necessary for the assembly of the whole. Vma12 is one of these latter, all three of which are localised to the endoplasmic reticulum [1].	25.50	25.50	25.90	25.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.75	0.71	-4.48	35	291	2009-01-15 18:05:59	2008-10-03 15:33:25	3	9	252	0	209	275	2	136.80	23	54.40	CHANGED	ppLLcuo..cl.alPs.s.psc.............................................osEahApht+L+tttcpccYp+hh........t................................st.t...sp.stthcpl+pQlssllNlllSVlusshulahhsp..h.............................shshssRlLLulhsullVhlAEVslYst.....Ylp+lccA+	..................................................................pLLcsocl.hlP.........s.c.............................................ssEhhAphp+L+tptppccYpchs+ssss.pp.........................................p...sp..s.pphcsl..+p...plhhlhNhllolhushhssahhsp.h.h................................hshssRlllulhsuhlVhlAElhlhst.hhpp.t...................................	0	66	110	171
+11545	PF11713	Peptidase_C80		Peptidase C80 family	Rawlings ND, Bateman A	anon	Rawlings ND	Domain	This family belongs to cysteine peptidase family C80.	19.70	19.70	19.70	20.60	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.92	0.71	-4.42	23	303	2012-10-03 02:24:44	2008-10-03 15:44:17	3	64	136	14	38	286	6	155.10	33	7.28	CHANGED	spastplIlQL..................psDslstcAAt....sLhuK+PssSlllQhss-......Gsh+slaus...............sstL.....sGpl+hQlVGHGcs....t.ssspLuGhsscpLAstl.....pphppthsssh......pPc..+IoLVGCshsus......ptpsuaspchhptlpsp.Gl........pssVSAppucVpV............-tpG+Kcsl	............................+achQlIlQh..................psDslst+.AAs....sLAuKHsp..sSlllQhDs-..........usaRlhYGs.....................sspL......sGK.lRWQlVGHG+s.........ptspspL.u.Ghss-pLAscL.....pphppttphss......pPc..+I..slVGCulsus..........spppuFupphhpthptp.uh........phslsu.ptcltl............stt.G++.h.h................................................................	0	18	28	35
+11546	PF11714	Inhibitor_I53		Thrombin inhibitor Madanin  	Rawlings ND, Bateman A	anon	Rawlings ND	Domain	Members of this family are the peptidase inhibitor madanin proteins. These proteins were isolated from tick saliva [1].	25.00	25.00	26.30	26.10	19.10	18.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.75	0.72	-4.00	3	5	2009-01-15 18:05:59	2008-10-03 16:12:31	3	1	2	0	0	5	0	78.20	59	98.99	CHANGED	MKHFAILILAVVASAVVMAYPERDSAK.DGNQEQERALhVKVQERoDs.DADYDEYDEDGTTPTPDPTAPTARPRLRGNQ	MKHFAILILAVVASAVVMAYPERDSAK.DGNQEKERALhVKVQERs-G.DADYDEYDpDuT..TPTPDPTAPTARPRLRtNQ....	0	0	0	0
+11547	PF11715	Nup160		Nucleoporin Nup120/160	Wood V, Coggill P	anon	Pfam-B_1841 (release 23.0)	Family	Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth [1]. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export [2]. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 subcomplex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 subcomplex, but rather that it regulates the association of the subcomplex with the NPC and other proteins [2].	19.20	19.20	19.20	19.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	547	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.63	0.70	-6.38	25	339	2012-10-05 17:30:43	2008-10-03 16:27:08	3	28	235	9	234	658	13	407.00	17	36.15	CHANGED	lslss....................tstsst.pssspsEcshtpchhsosu.....hhppshsRhlhWRhh.....ssscsLplpslslspsh.p..........sl+lpFspslh...ssslshs-ppsp......slhlhshssohplasLpltsshapp...............sshs-pshp-hspphsssshshptsthhsss........sssplhluhssGullclp+ps......pustapphphsstsh.ttlpshh.h........tttpht.ssssuhshss..htspsalh...slshcppL+lWslsotph....h..h............................st....tp.hphhhsssp.....sshhplh.....h.p.tpsstphhslhhus.psupFthaplp.ss....sss.hhps.hst........t.........slhshphp.hchs.sshclWsLW.cssssh.lpplphs.p................................tshpsshs.pssss.thhps.t..sDst.-palchlhpsu+aotpsl......cpALphapcsht.hpsps.s........sLpcclssslsuplphct..pt.h..........s.ppatptssppWp+FathstchccptpcPluLsl.sh....sss......shllpsssluhl..RsssshEpl	.....................................................................................................h.....................................................................h.hp..........tphltl....shtht..t........................................lphph.ts.h.....sh.h....tp.ttt...................hh.lhhhs.ps....h.hhhh.h....th..t.....................................th...t..p..p......shsh..s..hhh....................................s.t...hhls..h.t.....sGslhhl.p..h.......................s.hh......hhptt.h...t.lp..shh.h.........................tt....shshshsh..p..........p.p.s............a.........lh..............sls.sppL+hWshpstph...............................................................................................h.s..t....................t...h.h..........................................hh.hhh.h........t...tu.p.hhhhth..s................t..............................sl.t..t...t.....hp..........t............p.t.....p.....lasLW..p...s.pst...h..l..h.hph...t.p...................................................................................t.................t.............cs..phahp.lhts.sh..as.thl....................tpuL....hap.p...........................................ltpplh.slttph..p.p.............................tth.t...t.W.pahthh.php.thtts.h..ul.h..............th........................................hllhtt..huhh..h..t.h-................................................................................................................................................	1	67	116	193
+11548	PF11716	MDMPI_N		Mycothiol maleylpyruvate isomerase N-terminal domain	Bateman A	anon	Bateman A	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.85	0.71	-3.75	100	2030	2012-10-02 14:44:17	2008-10-08 12:55:26	3	16	384	2	776	2315	367	128.60	18	55.18	CHANGED	ltsttpplsshlssLs.csp..hssPos.ssGWTltclluH...lststphhsth.............................h....ts...sh.t...........................stthpttsstssssllsthcpstsphtsshtshsspthhhhh....hssts......hhttphhEshlHthDls	..........................................................h.....tthsshlssls..ss..p.......h...s.s...P.....os..s...s.G..........W..........o..........lpcllsH.....ls.t.s...t.....p..hht..s.h..........................................h...........ts.............................................................................ttthp..t..t..s..s..h..s.s.s..p..l...h......st..hp.p...s..h..t...t...h.......h..t.t....h.....tt..h...........s...t..t.....................h.............s..h.........s..........hhhhhhh-hhhHt.Dl..................................................................................................................................	0	295	606	732
+11549	PF11717	Tudor-knot		RNA binding activity-knot of a chromodomain 	Wood V, Coggill P	anon	Pfam-B_4165 (release 22.0)	Family	This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.87	0.72	-4.26	56	1173	2012-10-02 16:56:36	2008-10-08 14:59:09	3	25	331	25	766	1153	19	57.70	30	10.62	CHANGED	ltlGs....+lhsp+..............csph+hAcIlpt+h.....ppsp.....................hcYYVHYhsaN+RLDEWVstcRlsh	.............................................................................h...Gp..+lhshc...........sshhacAcllp.hc..........ppsp.....................................................hpYa.VHYh.GaN.+R..........hDEWVstsRl..h......	0	255	376	601
+11550	PF11718	CPSF73-100_C		Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term	Wood V, Coggill P	anon	Pfam-B_2254 (release 23.0)	Domain	This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins. The exact function of this domain is not known.	19.90	19.90	21.50	21.50	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.29	0.70	-4.98	35	365	2009-01-15 18:05:59	2008-10-08 15:00:35	3	12	290	0	246	354	0	216.70	26	31.03	CHANGED	cGp..hl...SGlLVpps..FshpLluPsDL+E.YosLoToslsp+Qslplsus.h-LlpatLcphF.G....tl-.lsccc......................................thlVMsslslhhcppp........lplEWpu.NhhNDslADoVhAlLlsl-SSPAuVKtouppp..p.............................ptp.s.ppphcplhhhLcspFGss.hs.hppsc.....................hhlphspppuslsh......pshss.-sp.......scsLcpclpshlpRhpphstPl	.....................................................................................................sp.hlSG.l.L.Vpcs..Fshp.lhuPpDLpp..YosLsso...slp.......Q+Qslshsus....hs..L...lp..a..tLppha.G....slEplpppc...................................................................................................t.shhVh.t........s.lslphpsst...........lhlEWtu.s.hNDhlADuVhslllplpus.PtssKtssp...t...t........................................................................................t.tp.....p.p.....hhcpl.hhLps.FGcs..h..htpsp.......................................................................................................h.lpl.stppAplsh.................pshpl...csp........spsLcphlp.hhp+hhphhhP............................................................................................................................	0	86	140	205
+11551	PF11719	Drc1-Sld2		DNA replication and checkpoint protein	Wood V. Coggill P	anon	Pfam-B_1966 (release 23.0)	Family	Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent relicensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5 [1]. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication [2].	28.00	28.00	28.20	29.10	27.80	27.90	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.87	0.70	-5.39	23	196	2009-09-11 16:31:55	2008-10-08 17:09:09	3	11	170	1	145	183	0	323.50	21	46.24	CHANGED	hspL+sELKpWE+sFtspN.GRcPsRsDIKpsPEIutKYKpYscLKs..supts..............pspKRcp...............sh....psspTPpKs.............................t.p...t....p....ps.................shcstlGPTPQtsGKsLuLF.Dhh.ps.t......................ssuoPoss+hsospssss...........................pTPoKpctsh...............tt.tsptc.ssp...tcTPhssscchhlst.h........p...............................................hpTPsaL+R..............pp.sh.s.t.................................hSPpPl+..p+.hs....KuLSplsp.....Ec-plc--h-lLcEhEsEpt.................................p.tppphsDspss..................................................tsp.spshKKK..sQKRoTR+V+M+Psh.tcspspsphspsDhccE...........h..................................................................shhcpcsho-hhsph...t.p..sppcctpcscsptcpp.............tpspt.+K.............lpssup...Na+RLKlps+..tptp..hpuRa.pRR	......................h.tpl+hcLKpWE+sFtppp.GR+Ps+pDI.K.p.s.s.c.ltthYKp.Ypp....L+p..ttps...............................................t.pctpt..............................s.psPtpt......................................................................................hss..s.........................................................................................................os.p.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	39	70	114
+11552	PF11720	Inhibitor_I78		Peptidase inhibitor I78 family	Bateman A, Rawlings ND	anon	Bateman A	Family	This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.87	0.72	-4.24	8	389	2012-10-01 19:32:51	2008-10-13 17:23:26	3	4	345	0	161	477	26	62.50	29	58.57	CHANGED	CsApshQsLVGQPhssspssph.....spslRVl+PGDhlTMDYpssRLNlhlDtsssIosl+CG	........................C.st.hpthlGp.s..h...os...t.h.p..ph..........hsptsR..llp...P..G...sh.lTMD.......apscRLNlplD.s.s.spl.pplpCG..........	0	32	86	132
+11553	PF11721	Malectin		Di-glucose binding within endoplasmic reticulum	Finn R, Coggill P	anon	Pfam-B_783 (release 23.0) pdb_2jwp	Domain	Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186.  NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan [1].	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.30	0.71	-4.49	62	826	2012-10-01 23:47:32	2008-10-15 13:30:42	3	160	245	3	487	1418	44	162.90	26	22.05	CHANGED	hshtlNsGGsph....tsssGhhYpsDpt..suss..ph..t................................ht.stshhtspsp.....pLYpotRh.......us..o..hpYhh...........hlpsGs..YslpL+FAElhass......tthGcRlFDlhlpu.phllcsaDIhp..cusGhs.tsshcpa.ss.sl.ssstLp.......Iphhhhtpsp..l....ushs.Ph.IuAI	.................................................................................htlNsGutth........s.ts...h...hapsDt.....ssst.......h..t...........................................htp.st.th..s.stss.......tL..apTt...Rh..........u.t...o.....hp.Y..hh................h..ht..sG..s...YsV.........pLpFAElhass................tthGp.........R..l.........FDlhl...p.........G..p.............h.....lhc-...h...D..I.....hp.......psG.....uts......sshcp.h.....ss..sV..ss.s.t.Lp.......lc.hh......ht..st........uhhs.PhlsAl....................................................	0	154	331	413
+11554	PF11722	zf-TRM13_CCCH		CCCH zinc finger in TRM13 protein	Andreeva A, Bateman A	anon	Andreeva A	Domain	This domain is found at the N-terminus of TRM13 methyltransferase proteins. It is presumed to be a zinc binding domain.	20.90	20.90	20.90	22.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.61	0.72	-4.57	27	181	2009-01-15 18:05:59	2008-10-20 16:55:17	3	11	158	0	116	172	2	30.90	40	6.89	CHANGED	thpCpaal.+K+.R....hC+Mtt.ttGspaCspHts	........pCpaalt.+K+.R....aC+Mss..tsGp...paCGEHt....	0	38	62	97
+11555	PF11723	Aromatic_hydrox		Homotrimeric ring hydroxylase	Radauer C, Mistry J	anon	Pfam-B_24837 (release 22.0)	Domain	This domain is found on aromatic hydroxylating enzymes such as 2-oxo-1,2-dihydroquinoline 8-monooxygenase from Pseudomonas putida and carbazole 1,9a-dioxygenase from Janthinobacterium. These enzymes are homotrimers and are distantly related to the typical oxygenase [2].  This domain is found C terminal to the Rieske domain which binds an iron-sulphur cluster.	20.50	20.50	20.60	20.90	20.40	19.00	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.59	0.70	-5.07	7	55	2012-10-02 19:24:03	2008-11-07 17:10:43	3	3	44	49	16	58	6	216.30	38	59.09	CHANGED	aVGDu-...PsPLtcDlPPs............FLD-Dhtlh.G.+RhlpuNWRLulENGFDsGHlaIHpsS.hVhusDhAlPLGF..tP.uDcsth..shs-s.suPKGlhchh......scHh.PlFEusl.GpsshtGphh..pthVu...............lplSlWLPGVLKV-sFP.PshhpaEaYVPIDEsoa.YaphLu+hssocE-tcsFcsEa.cpcW+chAlpsFNDDDlhAR-uMpsFYusDpGWscEhLapsDtsIltWR+LsSp+sRGIQ	......................alGDt-....PPPLscDlPsp..................hLD-shslh.GhpchltuNWRlusENGFDsuH.l.alH+sShllcspDhsLPLG..h..hP..sspst...ts..-t..stPKGlhshh......s-phhP.lh-shh.G..shtss.t.....hhs...............hp....hSlWLPGVL+VpsaPtPchsQaEaY.VPID-spH.Yaphls+hssscc-tpsFctca....cpt...ahsh...sLpGFNssDlaAREuhpsFYs-spGWspE.LhcsDhuIltWR+LAScasRGI........................	0	7	13	15
+11556	PF11724	YvbH_ext		YvbH-like oligomerisation region	Bateman A	anon	Bateman A	Family	This region is found at the C-terminus of a group of bacterial PH domains. This region is composed of a helical hairpin that appears to mediate oligomerisation based on the known structure. This elaboration of the bacterial PH domain is only found in Bacillales.	21.50	21.50	22.50	26.10	20.10	21.40	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.92	0.72	-4.29	7	123	2009-01-15 18:05:59	2008-11-09 20:00:03	3	2	123	6	16	66	0	60.40	65	30.21	CHANGED	-aAcpSLshAsslhsphR.t.csslsppFKchschAFsWLssshppashKDFG.VF-KYIpN	........QYAHKSLDMASNAFSR.ISNA.QVNLAEQFKEMNEIAFNWLVDTKKQYNVKDYGFVFEKFINN...	0	9	12	14
+11557	PF11725	AvrE		Pathogenicity factor	Mistry J, Coggill P	anon	Pfam-B_735 (release 23.0)	Family	This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system [1]. The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas [2].	18.10	18.10	19.80	19.70	17.80	18.00	hmmbuild  -o /dev/null HMM SEED	1774	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.70	0.69	-14.34	0.69	-7.55	9	200	2009-01-15 18:05:59	2008-11-11 16:24:21	3	3	58	0	14	220	0	959.80	27	91.93	CHANGED	Mp....h.slspspsssltssssssssssssLpQ.pspsssQpuutSLsu.G.+shtphsplpQ..........pspussppsAs.....................sPps.ss.tts......tt.phtp.ht...p....p...st....p.t.........................................ph.ts.lsp.u................t.Phsptpssssshstpt.ssst.ts.stssQpsssuc.ct.pppthttpcsssPt...........t.hpstLstss...tuphchpspph.pshpspss............IoLDscGK.pFushpsPAlssLLcppLGKssQsYLAHpusssup....pHhLL-spGHLhcltps-suhull+SSpssshh...utscsssVpLppcssplpls...pupspts.sLPGcAHhAhLoGl.......phsssG-plRlHDDKlaphss.huhWp...ssc-ssaSpLospGDGplYA.+sscsLsNLSSsp..hschhlcclpSFSVu.cGpVAlLospDops.pLs.Mssl.us.ts+hphoLcLss.......Gcu..pApuVuLos-RLFlADo-G+LYSAsRsphcss.-s.LchhPpps.....spthGtccploGFhosDcGQlpALlKsp.GphHupsLs.pssphcsGWNLoDuLVl-NphGLssh.sPssccpLsLsRtGplGLp-G+lphaDusTcsWc-Aul.DhcpLpRGhDusAYlLK-Gcl+cLsls.cpsshsaucssshA.sthpsKsEhGsAlpGL-.scslpAhAhlusppFlALDDpGclpuHp.KsGp......PhsLo+cGLsG-lKslsLDccpNLaAlTpsGcLFphsREsWQssc.us.....................................................upWptlshP.sppslcuLtssscpplssplcD.......uhhpL+utpWpshps+.....sstpsuhpslFsRLspuhKshpIPGTGlTl+hssphhG+oGhEppp.+SphuEhlRAalapsThpsPRPhKNsu.plQHRapGR-GLptVYchpuhLhKQL-...pssupssssupDLpo+lspLD..LG.cGtpLlc-LcpFR-ELEspuppAlhhlG..........QppGVLNppGplscptK.....tt.tthspthNhppSG+DLsKtLpsAlppsuPSspssstpLLpphhssGlchSHpKuDhPhGppRDssDcpuLoKuRLsLDlVTLs-LtcLlDKAchlospss..stlppLcpcLssLR-ppYG-NPVKphTDMGFTcNtALEusYDuVKuFlNAF+KtcHAVSVshRsshtopsQu-LAcKhKssLhpL-pG.-pIuhoRSYGssLoTsFlsh..schsssshPuAGhTssRNYsLshpRs-GGlsVhhhR-GusssosuVuuG+DlhPhhsscspsAc..Ss.lusc++hsPshRlGusloushptoppsulsFsls---lsuFlDsLhpGpLsPLplLcKGh-Hps+pu++hsFslssuuss-LRsGlslo-.......ssScPhoAssRsusGhssosNLhohoctp.TQcs-pophppuScNRPRFhNssshGAphpsplusuHss.pts.............sootst.psGo.sAhssssVssslulDsRTspplphchKpApPlTspslscLopoLGcsFKDsAopthLucLtc.psuc.....Pc-....pLcuLpchFus+sspsDcQYcALRsLK+hsscpcAu.scpusLDsARapTsYTNLS+LsppulhshIhsplpuAhsPoNAsRluchMspDPtLKullKphQuSsuT.ApVpLE.KDsLhD+l-cG.h-GplspcElusLhpDRNNhRI+ulsV.posspoEGFsoPTsLlSsssSAulShsKsLGpINFhYGpDQ-pPpuaTl-GElu+ssssltsAhscLKK-GhEhKS	........................................................................................................hh.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sth.............t..tt.hp..tttla.hp........Wt.......t..t..hs.l.hthpGphh..psst.h.p.ss...............h..s..stssh..t..............................................................t..........h.thsh...t.t..p..lhhhstpsthh.h........................................................................h.hsh.........s.......t.t.pstWphpp..hh..p.Gh........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	0	4	8
+11558	PF11726	DUF3296		Protein of unknown function (DUF3296)	Mistry J, Coggill P	anon	Pfam-B_768 (release 23.0)	Family	This family is expressed in Gammaproteobacteria. One of the E coli members is annotated as yagK, but otherwise the function is not known.	22.30	22.30	22.30	23.00	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.31	0.71	-4.71	36	1241	2009-01-15 18:05:59	2008-11-11 16:48:00	3	3	492	0	89	791	27	153.40	27	81.94	CHANGED	ppltpslcpslscasRlhslRlDL+hPp..ph.sp.....s..........sslocFhpsLcsplptp.................phhpspltYlWs+Epsp.ss..phHYHlsLhlN.p.a.t.Gphppps.slsspIppAWtpuht.hth....cspsllphs....cps.....tYhls...htpts.ppshc..slhhRlSYLAK..tcoKph.spt..t+sFGsSp	.........................................hpphlpthhp.as+......lhshRlDlth.c....s.ssh......st...........................tsls..phhptLps......clp......................p.h.shltYhWshEasp..pt..thHhHhhlhls...............Gph.p.t..........s.........pl..uthIppsWp.psht.....sh..........phtshsp.hs...tps......................................thhlp..............t.s.stpshp..pl.h...p.h.sYLAK......tc..s....Kth...s......psaGpS....................................	0	20	37	61
+11559	PF11727	ISG65-75		Invariant surface glycoprotein	Mistry J, Coggill P	anon	Pfam-B_785 (release 23.0)	Family	This family is found in Trypanosome species, and appears to be one of two invariant surface glycoproteins, ISG65 and ISG75. that are found in the mammalian stage of the parasitic protozoan. the sequence suggests the two families are polypeptides with N-terminal signal sequences, hydrophilic extracellular domains, single trans-membrane alpha-helices and short cytoplasmic domains. they are both expressed in the bloodstream form but not in the midgut stage. Both polypeptides are distributed over the entire surface of the parasite [1,2].	22.70	22.70	22.80	23.80	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.08	0.70	-5.35	20	223	2009-01-15 18:05:59	2008-11-11 17:19:18	3	4	11	0	71	209	0	254.70	29	57.37	CHANGED	thlhhhhssllhhslshApttph.......pus+KLsp-GApuLCph+cLucpV.scpuDplhccspphsstlptthcplp.hhpplt............c.s-ucpccl+phhpcAKpclpctltp.ucphsccsccptpclKcAApcAht.t.p..tt.pSsGLpcVLsWaCtsp....scst..s..spNC.-slshppch......ssst+ssIsC....sttspss.hpssosssMcpAl-pWspsKP.......K.....c.t.psssstCpp.ts.stspPCTlhEp.WpscYcsuhpclccLEcstcpuppstct	.....................................hshhlhsshhslslshupp.s.hs.t.......hss+pLstpuAtsLCpMK+Ll-sV.sspsDph.c.ppshpa.l.ssspt.thp+l..............................S-pcphpsshsps..+hpthpthpp.usphhctht...cptccAKpAAssA..................Ss.u.LpclLcWHChsc....tcs..t.s...ssNC.-sssa+cca........cspphsI....C....phpshssspspsThu.sMctAL-tWsps.KP..........K........hph...susstssp.pusssscPCTlhEs.WhhsYcsstphltcLEpshp.uhtshc.h.............................	0	45	71	71
+11560	PF11728	DUF939_C		DUF939 C-terminal domain	Bateman A	anon	Bateman A	Domain	This region is a presumed intracellular domain found in a set of bacterial presumed transporter proteins. The region is about 160 amino acids in length.	21.50	21.50	21.60	21.50	21.20	21.40	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.95	0.71	-4.44	30	916	2009-01-15 18:05:59	2008-11-13 17:09:13	3	3	912	2	73	425	1	166.60	34	52.19	CHANGED	h-cclccapppIEpph+pILhchuthLpssctp..hpstplscLcphlccA+slAa+chcNph.h+pcshYh+YF-MRcpQh-lLc+MhsplsslphsscQsphlAchhcclusslppsNsuphhLccLpch+cpFcchsLPpTREEFEsRAsLaQhLp-hEpaLhlKsp	........-cclccY+pplEpph+cILpchs.aLpptps.........c....sp........u.......t.htcLcph....lccAppluap-hcNa.h.h+.....p.s......sYah+...YF-.MRp..pQsclLcpMtt.lsslphss...pputhlApLhpclut....slspsNsusphLcc.l.pchhpha+ph.sLPpTRcEFEsRAsLlQlLpEhcpalplKs.....	0	25	44	59
+11561	PF11729	Capsid-VNN		nodavirus capsid protein 	Mistry J, Coggill P	anon	Pfam-B_805 (release 23.0)	Family	The capsid or coat protein of this family is expressed in Nodaviridae, that are ssRNA positive-strand viruses, with no DNA stage. These viruses are the causative agents of viral nervous necrosis in marine fish.	35.30	35.30	35.30	92.30	35.20	35.00	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.16	0.70	-5.48	3	443	2012-10-04 01:49:40	2008-11-17 14:19:14	3	1	133	0	0	217	0	193.10	74	99.75	CHANGED	MVRKG-KKLAKsATTKAANPQPRR..RsNNRRRsoRsDAPVuKASTVTGFGRsTNDVHL.SGMSRIuQAVLPAGTGTDGaVVlDpIIVP-LLPRLGHAARIFQRYtV-TLEFEIQPMCPANTGGGYVAGFLPDPT....DuDHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSoGKEQRLTSPGRlILLCVGNNTDVVNVSVLCRWSVRLSVPSLEpP.EplAsPILTQGsLYNDSLostYN...................HFcSlLLGSTPIDlAPTGTIF.QLDRPLpIDYSLGTGDVDRAsYWHF+KhuGNls+PAGYhpWGlWDuFN+TFTsGlSYYSDsQPRQILLPV......GTlpsRhDSEN	...............................................................................................................................ANTGGGYVAGFLPDPT....DNDHTFDALQATRGAVVAKWWESRTVRPQYTRTLLWTSo...GKE.QRLTSPGRLlLLCVGsNTDVVNVSVhCRWSVRLSVPS.LETP.E-TTAPIhTQGsLYNDSLuT..N...................DFKSILLGSTsLDIAPDGAVF.QLDRPLSIDYSLGTGDVDRAVYWHLKKFAGsAuTPAGWF+................................................................................	0	0	0	0
+11562	PF11730	DUF3297		Protein of unknown function (DUF3297)	Mistry J, Coggill P	anon	Pfam-B_797 (release 23.0)	Family	This family is expressed in Proteobacteria and Actinobacteria. The function is not known.	19.10	19.10	19.10	100.60	17.40	19.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.18	0.72	-4.29	30	320	2009-01-15 18:05:59	2008-11-17 14:20:50	3	1	318	0	106	230	31	70.90	61	82.61	CHANGED	PDRLSssPcSPaass-lLpRslGIRFpGpE+TsVEEYClSEGWVRVsAGKAhDR+GpPhTIKL+GsVEsaa	.PDRLSsNPRSPaastEsh-+..sIGIRFNGcERoDVEEYCISEGWlKlsusKAhDR+GNPhhlpLKGsVEAaY.	1	15	52	79
+11563	PF11731	Cdd1		Pathogenicity locus	Mistry J, Coggill P	anon	Pfam-B_826 (release 23.0)	Family	Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria [1]. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.	25.50	25.50	25.50	25.70	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.91	0.72	-4.06	25	195	2012-10-03 02:11:09	2008-11-17 14:34:06	3	3	188	0	48	189	25	90.70	35	88.25	CHANGED	M..........s+s.scs..................................thpcLpcLPNlGcAsApDLphLGIppsppLtGccPhchYpcLschoGpppDPCVlDVFhulspFhpGp..-....spPWWpaTcERKpt	...................................................................................ppLpcLPslGcuhstDLp.hlGIcplssL+GcsPh-lYcch...Cphp.G...pphDPClL.latssVhahpspp......hp.WWpap-cp+t.............................	0	20	33	40
+11564	PF11732	Thoc2		Transcription- and export-related complex subunit	Mistry J, Coggill P	anon	Pfam-B_819 (release 23.0)	Family	The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats [1]. In humans, the TRE complex is comprised of the exon-junction-associated proteins Aly/REF and UAP56 together with the THO proteins THOC1 (hHpr1/p84), Thoc2 (hRlr1), THOC3 (hTex1), THOC5 (fSAP79), THOC6 (fSAP35), and THOC7 (fSAP24). Although much evidence indicates that the function of the TREX complex as an adaptor between the mRNA and components of the export machinery is conserved among eukaryotes, in Drosophila the majority of mRNAs can be exported from the nucleus independently of the THO complex [2].	20.40	20.40	22.10	24.10	19.10	20.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.41	0.72	-4.19	22	297	2009-01-15 18:05:59	2008-11-17 15:09:49	3	5	248	0	207	292	3	75.90	44	4.48	CHANGED	luKlsasNPhhshpshLpQIcsYDNlhphVV-ssKYhosLuaDlLsasllppLs.ssRsphppDG.hs.uhWlpuLus	...luKluauNPsllhch....lLsQIpsYDNLIssVV-.sh.KYh.TsLsYDVLsa..........sl..lpuLu....p.s......p.....+p+hpcDs.hshSpWLQuLAo...............	1	67	114	171
+11565	PF11733	NP1-WLL		Non-capsid protein NP1	Mistry J, Coggill P	anon	Pfam-B_837 (release 23.0)	Family	This family is the non-capsid protein NP1 of the ssDNA, Parvovirinae virus Bocavirus of cattle and humans.	25.00	25.00	96.70	96.00	21.50	19.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.32	0.72	-3.73	3	376	2009-01-15 18:05:59	2008-11-17 17:06:10	3	1	14	0	0	133	0	93.50	90	83.10	CHANGED	MSScsTKD+HRSpKRpsSPhR-ERKRsWc.p++SRSRSPIRR+GE+ShGSaRppsQ-s+QSSsTASKsSDpATKTKEsTSG..sTRTNPYTVFSQHR	MSSGNMKDKHRSYKRKGSPERGERKRHWQTTHHRSRSRSPIRHSGERGSGSYHQEHPISHLSSCTASKTSDQVMKTRESTSGKKDNRTNPYoVFSpH.....	0	0	0	0
+11566	PF11734	TilS_C		TilS substrate C-terminal domain	Sammut SJ, Bateman A	anon	pdb_1ni5	Domain	This domain is found in the tRNA(Ile) lysidine synthetase (TilS) protein.	21.00	21.00	21.10	21.10	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.34	0.72	-4.75	140	2601	2012-10-01 21:04:40	2008-11-18 16:14:21	3	9	2576	4	480	1909	354	70.80	26	16.01	CHANGED	lp.lRh+...tuGpchp...hs....+stsRpLK+laQEhslPsWhRs+lPLlah....s-.pL.lsss.Glhlspt.....h.s...........ttt..h....plp...W	................lplRh+...psG-hhph..hG....pssp.+KLK+la.-tplP.ht.R.c.phPl.lh........s.p..pl..lsl....s..Glhhspt.....h.................................................	0	178	312	403
+11567	PF11735	CAP59_mtransfer		Cryptococcal mannosyltransferase 1 	Mistry J, Coggill P	anon	Pfam-B_916 (release 23.0)	Family	The capsule of pathogenic fungi is a complex polysaccharide whose formation is determined by a number of enzymes including, most importantly, alpha-1,3-mannosyltransferase 1, EC:2.4.1.- [1].	25.00	25.00	25.00	25.00	24.70	24.20	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.54	0.70	-5.15	37	382	2009-09-11 16:30:58	2008-11-19 09:33:18	3	7	108	0	245	384	4	212.70	30	50.86	CHANGED	+lFIAhsLa.pstplltstastull....pLhchLGs.....-NVFlSIYEssSsDsopssLp.tLc..LcplslppsIhh..s.tschs..th......................h+RIsaL.............AclRNhALcPL.p....................ttpshtaD+lLaLNDVhFsspDllpLLhsss.................sp..........................................YstsCulDF...sp..s.pF.................YDoassRDhp.Gpth............shshaPaFpss....sspcshstppsl.VpSCW.........sGhsuhcAp.Fhtsp.........................slRFRu....sth....h-uSECsL....IpsDh.....ss	...............................+hahAhsla.pstpll.shhu.sllplhphLG.........................cN.lalS.lhEss.SsDpotshLp..hc..hp.....phsh.ph.lhh.......ppht........................................cRItaLAplRNtAlpP.L.p........................................t.t.s.ta...cpllF..lN.Dlh..hsst..DhlpLlhppp....................tp..........................................................hthsCu..hDa..............t..s.hF.........................................................YDsashRDhp.G.th.......................h.has..hh....t.st.............tppphh...t.t.sh.VhuCW.........sGhsshsst.h.....................................................................lpFRt.....t.......h.tuEspLhh.D.....s.......................................	0	69	141	197
+11568	PF11736	DUF3299		Protein of unknown function (DUF3299)	Mistry J, Coggill P	anon	Pfam-B_876 (release 23.0)	Family	This is a family of bacterial proteins of unknown function.	21.20	21.20	21.30	21.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.30	61	436	2009-01-15 18:05:59	2008-11-19 10:02:20	3	3	323	0	135	407	201	144.10	36	78.53	CHANGED	lsWp-Lh.P..ts.s................t.hspltsts.................thpps.sth.......................................pp.hsuslsppLsGptV+lPGalVPL-.sssttlTEFLLVPYaGACIHVPPPPPNQIVaVphscG.htlps.........LasPlWVpGpLpscphss.-lA........psuYshpusplpsY....c	.................................................................sW.-Lh.Pts..p.....h....................p.ts.s.................h.ppt..th.......................................p...suslsppLsGp..pV+lPGallPLE.....s-psplTEFLLV..P.YaGAC.IHVPPPPPNQIlaV+hs.cG...ht.lp.p.........las.slaVpGpL+scph.ss..-LA........psuYphpusplt.Y......................	0	38	74	105
+11569	PF11737	DUF3300		Protein of unknown function (DUF3300)	Mistry J, Coggill P	anon	Pfam-B_886 (release 23.0)	Family	This hypothetical bacterial gene product has a long hydrophobic segment and is thus likely to be a membrane protein.	25.00	25.00	26.80	30.50	20.70	24.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.72	0.70	-5.10	71	636	2009-01-15 18:05:59	2008-11-19 10:38:50	3	1	598	0	129	443	35	275.10	57	50.70	CHANGED	hopupL-QhlAPIALYPDsLLoQlLhASTYPL-VVpAsRW...psNspLpG-.........shhpAlpsps....WDPSVKuLlAFPplLphMu-clsWTppLGDAFLuQpp-VMsulQpLRppAppsGsLposppQpVsppp.ps...................................IhIEPAsPpVVYVPhYsPslVYG.sW.a.ssYP..Ph.Ya......s.Psh..........sshs..suhuaus.Glsl.uhsh.......a...uu.......hc..Wssc.....................................plslshpphpphstp...........sstpWp..Hs	....FSTAQIDQWVAPVALYPDuLLSQVLMASTYPsNVsQAVQW..S+..D..NPhhQGD.........AAIQAVu..sQP....WDsSVKSLVAFPQLMALMGENPQWVQNLGDAFLAQPQDVMDoVQRLRp..LAQQTGSLKSospQKVlossKpsssst.ssssss...........sshstsssTVIsIEPANP-VVYlPNYNPsVVYG.sW..sN....TAY..P..PV.YL......PPPsGpsF......sDSFV+GFGYSh.GV..ATTYAL......F...SS........ID....WDDDDHcHHccDpcs.t...............htpsussapHNGDNINIsVNNFNRIoGppLsspshs.........W...pss.....................................................................................................................	0	28	54	94
+11570	PF11738	DUF3298		Protein of unknown function (DUF3298)	Mistry J, Coggill P	anon	Pfam-B_854 (release 23.0)	Domain	This family of bacterial protein C-terminal regions is highly conserved but the function is not known. Several members are annotated as being endo-1,4-beta-xylanase-like, but this could not be confirmed, and the structure can be defined as a heat-shock cognate 70kd protein 44kd ATPase.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.83	0.72	-3.47	347	1368	2009-11-03 10:59:44	2008-11-19 11:12:14	3	22	951	4	301	1129	32	88.50	19	30.96	CHANGED	LpD.........l.hps..t.................hhptl......pphlppph.......t.....................pptt..t.................................ptht.shtt.......................................spsah..lssc......u.ls...lhas....Y-l....u........Pauh......G.hh....phplPhpp	................................................................................................................................................sl.hps...s............hhphl.pphlpppl....t.....................pp.pt..............................................................thh..tht....t................................spsFh......lssc........u.ll...lhas.YElu............Pauh...............G.hsphtlPht................................	0	106	205	258
+11571	PF11739	DctA-YdbH		Dicarboxylate transport	Mistry J, Coggill P	anon	Pfam-B_935 (release 23.0)	Domain	In certain bacterial families this protein is expressed from the ydbH gene, and there is a suggestion that this is a form of DctA or dicarboxylate transport protein. Dicarboxylate transport proteins are found in aerobic bacteria which grow on succinate or other C4-dicarboxylates [1].	23.00	23.00	23.10	25.50	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-10.98	0.70	-4.88	59	772	2009-01-15 18:05:59	2008-11-19 11:34:00	3	4	734	0	150	542	34	200.70	45	24.22	CHANGED	lplsplss.Glslsshphphphphst..........t.lplp.................................ssssshhuG.pltlsphshsh.pst..pshlplpslsLscllpl.shpsltuoGplsGslPlhlsss.thplpsGpLsucss.Gplphsssss..cshu..tss.shphshssLcshcYspLsuslshsssGchhlslplcGpN.....ss...........htsspPlplNhshc-NlhpLh+SLphu..splpptlc	............................................LRIAplhN.h.lss+NITADLQGpYPa...................oEppPLhLo....................................-VSlDVL.GGpl.hhcpLRhPQ.HD......PAlL..RLpNlSuSEL..loAl..s.P..KQ..FAMSGshSGuLPLWLNNc.KWll+DGWLsNsGP..h..TLRlDKDsA...DA....ls...............+s................N.h...oA...GsAI....s....WLRYMEIo+SpTcI.NlDNLGh.LThpAsIsGpS.+s........................csKsssVNLNYpHEENlFsLWRSLRFG..DNLQsWLE.........................................................................................	0	31	66	113
+11572	PF11740	KfrA_N		Plasmid replication region DNA-binding N-term	Mistry J, Coggill P	anon	Pfam-B_844 (release 23.0)	Family	The broad host-range plasmid RK2 is able to replicate in and be inherited in a stable manner in diverse Gram-negative bacterial species. It encodes a number of co-ordinately regulated operons including a central control korF1 operon that represses the kfrA operon. The KfrA polypeptide is a site-specific DNA-binding protein whose operator overlaps the kfrA promoter. The N-terminus, containing an helix-turn-helix motif, is essential for function. Downstream from this family is an extended coiled-coil domain containing a heptad repeat segment which is probably responsible for formation of multimers, and may provide an example of a bridge to host structures required for plasmid partitioning [2].	24.10	24.10	24.30	24.30	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.43	0.71	-3.66	107	609	2009-01-15 18:05:59	2008-11-19 13:15:57	3	4	377	0	187	552	51	116.60	23	36.79	CHANGED	lsppplhpA.ustLhspGp.......pP...........TlcsVRptlG......pGShsTlsphLccacppptsts.........stst...hP.ssltpshsphhtplhppApptAppplpptcpphptpttphptptppttpphpphppphpp	.................thpplhpA.sptLh.st.Gp.......pP.................ospsVRptlG.......sGShosl..sphlccapppppsts.................tss...lP.tsltp.....thsphhstLhpp...........Ap...p...tA....ppt..........lstt.c..........p....t...hptph...tp...hpp.phppt...ttphpphptpht.t.........................................................	0	27	74	132
+11573	PF11741	AMIN		AMIN domain	Finn RD, Coggill P	anon	Pfam-B_11438 (release 23.0)	Family	This N-terminal domain of various bacterial protein families is crucial for the targetting of periplasmic or extracellular proteins to specific regions of the bacterial envelope. AMIN is derived from the N-terminal domain of AmiC, an N-acetylmuramoyl-l-alanine amidase of Escherichia coli which localises to the septal ring during division and plays a key role in the separation of daughter cells.  The AMIN domain is present in several protein families besides amidases suggesting that AMIN may represent a general targetting determinant involved in the localisation of periplasmic protein complexes [1].	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.31	0.72	-4.03	172	2653	2009-01-15 18:05:59	2008-11-19 13:52:53	3	59	1806	0	715	2042	505	99.40	24	20.71	CHANGED	lclhss..ttth.clhlpos.tshphpshtl......ssPsRlVlDltssphshshp.........phpsssss...lpplc.ssp...pssssRlVlcl.ct...ssps........h..tppsptlllsl	...................................s...sp.s..+lslcts..p.....h...p....h.ptFsL.......ss.P.s..Rl.V.l...Dlpssshssshp.....................phph.s...ssh...........lppl..R..suph.......sss...s.sRlVl-L.cp.........ssps..........ss..tt.tpplhhs....................................................	0	182	458	606
+11574	PF11742	DUF3302		Protein of unknown function (DUF3302)	Mistry J, Coggill P	anon	Pfam-B_953 (release 23.0)	Family	This family of unknown function is expressed by proteobacteria.	21.00	21.00	21.00	21.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.85	0.72	-4.13	8	755	2009-01-15 18:05:59	2008-11-19 18:01:27	3	1	490	0	69	251	11	74.40	78	65.64	CHANGED	LDYFALGlLlFVslVlFYGlIlIHDIPYEIAK+RNHPHQDAIHVAGWVSLFTLHsIWPFLWIWATLY+P-RGWGhssh	.........LsYFALGVLIF.VFLV.IFY...G...I..IhlHDIPYLIAKKRNHPHADAIHsAGWVSLFT.LHVI.WPFLWIWATLYpPERGWGMQs.t...............	0	8	18	42
+11575	PF11743	DUF3301		Protein of unknown function (DUF3301)	Mistry J, Coggill P	anon	Pfam-B_952 (release 23.0)	Family	This family is conserved in Proteobacteria, but the function is not known.	25.00	25.00	39.00	47.80	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.07	0.72	-4.46	55	323	2009-01-15 18:05:59	2008-11-19 18:02:21	3	1	323	0	92	257	40	94.80	33	82.77	CHANGED	sLh...hlhll.shsshhaWpt+phpEhAhtts+ptCcchslQLL-tuhshp+hphtt...pGphphpppatFEF.SssG-sRYpGplhhhGt+ltplcLssa	.....sLhlllhl.shsshhaWpt+phtEhAhthscppCpchclQLLs.uhst++l.phsh...sGphphpphYtFEF.SssG-spYpGplhMhGt+ltplplsPa....	0	26	52	73
+11576	PF11744	ALMT		Aluminium activated malate transporter	Bateman A	anon	Bateman A	Family	\N	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.26	0.70	-5.82	18	320	2012-10-02 19:04:43	2008-11-20 17:12:55	3	13	54	0	205	1758	29	327.50	31	66.11	CHANGED	achG...+cDPRRVlaulKVGlALoLVSllYahcs.acslGssAlWAlhTVVVVhEFSl................GATLsKGLNRuLGTLhAGuLAluhphlu.shoGc...hEsllluhslFlhuhhATah+haPthKs.Y-YGhhlFlLTFsllsVSuYRscph.lphAhpRhhpIslGuslClhlslhlhPIWAGEDLH+LlspNhpplupuLEG..........................CVspYhcshEh-........hps.s--slapGY+olLsSpupEEoL............hsFApWEPsHGta+.a+aPWppYlKlGuslR+CAaplhAL..........HGCl..poEIQuP....p-lRstF+csht+luhEuuKlL+-Lucsl+pMc+sos..p.llpcl+hAscpLpppI.cspshLhlsop..t........t..........................................................................st...p.................hcshE.upuLslATFASLLIEhVARL-sll-ul-ELu	.................................................................................utpDs++hhauhK..hGl..uL.s.L.l...S..hh..h.h.h...p..........h.p.t...h....u.......p..u.h..W.Al.h.T.V.V.VV.h...E..a...o..l...........................................GuTlsKGhNRuhuTlh.AGhl..u.hs.h.t..lu...th.s.Gp.......h.ps.h.l..l..s..h...l..F...l....h............uh...h.....so.......a.h.+..h..h.Pt.......h.K.......a.-...Y...G...h.h.l..F.lLT.a.s.....l......l....s...V.......S........u.....a..........p.........s......p........p...............h.........h...p....h..A.........h......p...R..h.............hI.slGsshslhlslhlhP..l....WA....G...p-....LH....p.ss...tshpt..l....Ap.l.-u............................................hsppY.hp.t.t.t..............................ttp..hhp..sa+...ss.lpSp..s.p.--sl.............hthA..hWEP..HG.at...hpaPW.p.pY.+..l..............us.hhRp.h..u......h.Ah.............tu.hl.......s.p....p....ss......php....h....htt.h.phu.p.supsLct.hu.t....lpphph........t.hh.th.t.Ah.ppLp..l.p...............................................................................................................................................................................................................t.h.hh.hs..l.ch...hp.l..th..h....................................................................................................................................................................................................................	1	50	144	177
+11577	PF11745	DUF3304		Protein of unknown function (DUF3304)	Mistry J, Coggill P	anon	Pfam-B_956 (release 23.0)	Family	This is a family of bacterial proteins of unknown function.	20.60	20.60	21.10	20.70	20.20	18.60	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.67	0.71	-3.89	44	431	2009-01-15 18:05:59	2008-11-24 11:52:26	3	5	195	0	98	376	5	114.60	29	62.93	CHANGED	sLuuCspst...................sshtuhs........lhuhNaTshsItpFhl..sGt......hGusshss.......huGGGGtsCChslPppW+.GhplpVcWp.......................ptphtp.p.tsphtptt.VslPphsth........sshlpV+FLPscclcl	........................................................................h...sssps............................sshsuss...lpshNahc.h..s..IhtFsV...sG..............tGusshu.........sGGGuhsCChsls.....GhsscVpWp......................................hpptphtt...thph...pp...pphs.lslPchpht........pshLpVHFhPsc+Vc..................	0	10	27	46
+11578	PF11746	DUF3303		Protein of unknown function (DUF3303)	Mistry J, Coggill P	anon	Pfam-B_958 (release 23.0)	Family	Several members are annotated as being LysM domain-like proteins, but these did not match any LysM domains reported in the literature.	21.10	21.10	21.40	21.90	20.50	20.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.92	0.72	-3.61	33	128	2009-01-15 18:05:59	2008-11-24 11:53:10	3	1	72	0	67	134	549	85.20	24	86.48	CHANGED	hallpapF.sspsp..s.pshtcahcsG..t.t-p..-GacllsRhHsPtsupGhslscA-sspslacahtsWpcthslph-lsPsloDpEhls	.....................halhphpF.stppp....pshtcahcsG.....tsh..-GhchltRhtssssupsahlscu-ssptlacaht.Wtch..hch.-lsPVlosp-hs....	1	7	33	49
+11579	PF11747	RebB		Killing trait	Mistry J, Coggill P	anon	Pfam-B_983 (release 23.0)	Family	RebB is one of three proteins necessary for the production of R- bodies, refractile inclusion bodies produced by a small number of bacterial species, essential for the expression of the killing trait of the endosymbiont bacteria that produce them for attack upon the host Paramecium. R-bodies are highly insoluble protein ribbons which coil into cylindrical structures in the cell and the genes for their synthesis and assembly are encoded on a plasmid. One of these three proteins is RebB.	18.80	18.80	19.50	20.70	16.40	17.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.23	0.72	-4.10	32	294	2009-01-15 18:05:59	2008-11-24 15:51:45	3	1	94	0	104	256	12	66.90	41	67.18	CHANGED	ITDuVT.QsNscVlGpAPAhAMGslaQusup.uh.....uluhpNAVsuQQptphhupAusspGVstlhohsosus	..............ITDuVT.QsNsKVlG.-APAhAhGsLYQuhup.uh.....uhshcNAs..suQQQtphhupAuostGltplhulssss.s..........	2	31	51	92
+11580	PF11748	DUF3306		Protein of unknown function (DUF3306)	Mistry J, Coggill P	anon	Pfam-B_984 (release 23.0)	Family	This family of proteobacterial species proteins has no known function.	25.00	25.00	42.50	41.60	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-3.43	58	273	2009-01-15 18:05:59	2008-11-24 16:08:42	3	3	268	0	74	236	87	114.20	32	54.64	CHANGED	uFluRWSR.RKtss..................ts-psst.t......................ssssstssssptsptsphsspchht...................sLsDs-sl.s.ssDhssFhsc.sVsppl+psALR+Lap.sPtassh.DGLs-Ys-Da.ossssls	.........FhSRWSp.RKhps..................ps-p.hpst.....................................s.sstss..s.ts.tspsshp.sppshp...................sL.ssscsl.stpsshusFlss..slspplK+AALRKLFh.sscFsth.DGLc-YstDYossssl.s........	0	13	36	54
+11581	PF11749	DUF3305		Protein of unknown function (DUF3305)	Mistry J, Coggill P	anon	Pfam-B_976 (release 23.0)	Family	Several members of this family are annotated as being molybdopterin-guanine dinucleotide biosynthesis protein A; however, this could not be confirmed. The family is found in proteobacteria.	25.00	25.00	26.40	31.60	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.91	0.71	-4.31	51	269	2009-01-15 18:05:59	2008-11-24 16:10:00	3	3	264	0	73	213	96	134.40	34	80.71	CHANGED	htluVlhc+ps....ssRWsshpWphsullP.......sts.......phLppc...st..pahhsshslcLa+s-spuYhhNLsupsPslaVlh+tspss................hpshhlTAS.t-Atsa....hDsG-p.V-plPMP.sltuWlpAFlspHa..E...hKR+...Rc	.......................htlhhpct.....suRWtshpWplpuhh.........................pshtps...p.......sshsLpLa+DEpssYRhNLoopsPpLFllhcpst-s..................hpsstlTAS.s.Aupa....hD.G-phV.sssMPhslpAWhcAFlscHt..E..th+RK+c....	0	12	35	53
+11582	PF11750	DUF3307		Protein of unknown function (DUF3307)	Mistry J, Coggill P	anon	Pfam-B_1017 (release 23.0)	Family	This family of bacterial proteins has no known function.	20.60	20.60	20.90	21.00	19.70	20.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.07	0.71	-4.40	37	380	2009-01-15 18:05:59	2008-11-24 16:32:56	3	1	364	0	129	369	88	125.40	23	62.06	CHANGED	hlllhLllAHlLuDFhhQspphlppKpp.....+sphLhhHhhIhhlhhhllhhhhth............hhhhlllsloHhlID...hhK.hh.pt......................shhhFllDQlhHlhl..llslhhhh..................h..h.hhhhh.phlhh	............hhhhLl.luHlluDFhl.Q........opphu.ctKpp..................pht.hLhhHhhl.hsls..hhll.h.h.h.h.s....................hhhhhll...hlo.HhlID.........hhKsthtpph.............................phhhF...l....l....DQhlHlls...lhhlhhhh............................hhhh.............................................	0	40	87	112
+11583	PF11751	DUF3308		Protein of unknown function (DUF3308)	Mistry J, Coggill B	anon	Pfam-B_993 (release 23.0)	Family	Some members of this family of bacterial proteins are annotated as being one of the several TonB-dependent siderophore receptors, but this could not be confirmed.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.76	0.70	-5.10	103	599	2012-10-03 17:14:37	2008-11-24 16:45:15	3	4	144	0	319	828	889	278.90	23	82.68	CHANGED	stuppcspaoQYhh.NhhhlNPAaAGspss.hplthhhRsQWsGl-......u..APpT.shohss.lsc..ps..............GlGlslhsDphGs...hspsshtssauYplpl....ucpsp...........L........oFGlpuGhh.hsl...chsphs..........sssDs.thtt.......sphhsslusGhhahs....c......paahGlSsssll....ppphspsstt.........sp.thpahhhuGYsFshs................phphcPuhhh+hstss....sh......plDlssphhhpt..............phhhG...suYR..................hs....pulushlGhphs.....shhlGYuYDhs..hss.lst..hssGoHElhlta	.............................................................................................h..uQpsspaoQYhh.N.hhlNPA.....h..uG.t.....p..ss..hplthh.aRsQWs.Gl.c..................s..uP...pThshuhstslsp...pp................................GlGlpl..hsD.phGs.....hspsshtssauYp.lpl...........spp...tp................LuhGlpsGhh..phsl...Dhsclsh........................sssDs.hhsss..............sphh.s.husGlhahs........s...............paah..GhSs.plh........s.phs.sstt......................sp.thpahhtuGYhhsls....p...................phph.c...Puhhh+hs.tss.sh..........thDlssp..h..hhpp..............phhhG.....suYR....................hs........sulsshhGhphs...........phtlGYuY-hs..hss..lst......hssGo..HElhlta............................................................................	0	176	283	319
+11584	PF11752	DUF3309		Protein of unknown function (DUF3309)	Mistry J, Coggill P	anon	Pfam-B_1113 (release 23.0)	Family	This family is conserved in bacteria but its function is not known.	20.90	20.90	21.10	20.90	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.76	0.72	-4.18	41	288	2009-09-10 20:38:52	2008-11-25 14:50:30	3	1	240	0	131	241	23	49.00	56	91.77	CHANGED	uTILLIlLILlLlGuLP..sWsaSRuWGYuPSGhlGllllllllLlLhGRI	................GTILlIlLILlLlGulP..sWPaSRuWGYuPSGhlGllllIlllLlLhGRI....	0	22	65	91
+11585	PF11753	DUF3310		Protein of unknwon function (DUF3310)	Mistry J, Coggill P	anon	Pfam-B_1078 (release 23.0)	Family	This is a family of conserved bacteriophage proteins of unknown function.	20.10	20.10	20.10	20.40	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.28	0.72	-4.02	30	564	2009-01-15 18:05:59	2008-11-25 15:45:59	3	7	485	0	27	404	1185	61.10	40	51.67	CHANGED	sVsp..PsHYp..psslEsI-hI.t.ht..hpphhuah.hGNslKYlhRhp+K.NG...hEDL+KAtpYlch	..................................lpp..PuHYs........h.......ssl...EhIDhI.p.hs.........h.tthuFs.hGNulKYl...sR..s....st....K..sG...................pEDLpKApaYlp.............	0	6	17	23
+11586	PF11754	Velvet		Velvet factor	Mistry J, Coggill P	anon	Pfam-B_963 (release 23.0)	Family	The velvet factor is conserved in many fungal species and is found to have gained different roles depending on the organism's need, expanding the conserved role in developmental programmes [1]. The velvet factor orthologues can be adapted to the fungal-specific life cycle and may be involved in diverse functions such as sclerotia formation and toxin production, as in A. parasiticus [2], nutrition-dependent sporulation, as in A. fumigatus [3], or the microconidia-to-macroconidia ratio and cell wall formation, as in the heterothallic fungus Fusarium verticilloides [[4].	25.00	25.00	25.80	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.52	0.71	-4.72	28	414	2009-09-11 07:54:36	2008-11-25 15:51:15	3	6	103	0	314	445	0	200.10	30	48.62	CHANGED	shpYcLpVhQQPhRARACGtGs................tDRRPl..DPPPllpLplh-tss....ppt-hshlpssha.hlhssLhssc....shspsph.t.sssss.................................................................................................pshLoGshVuo....hthLc-ssst..................................usaFlFsDLSVRpEGpYRLpFpLhchstts..........................stsssshhs-lhS-sFsVaoAKcFPGht-STsLS+slA-QG..s+l+lR+....-sRt	..................................................................................................................................................t...apL.lhQpP.tARhsG.st..................................t-R+..Pl..sPPPllpL.h...lhc...tp...................tt.s.s....h.ps......a.hhhssL.ssp.......s.tp..sth...............................................................................................................................................................................................................................................................................................................tpsLhGshsuu....hhhL..pc.ssst......................................usaFlFsDLSVRpEGpaRLpFsLhchst.t............................................ttsshhtpshSpsFpVasuKcFP...Ghhp.S...T.Lo+thupQ........G..h+l.lR+.cs.......................................................................................................	0	113	182	260
+11587	PF11755	DUF3311		Protein of unknown function (DUF3311)	Mistry J, Coggill P	anon	Pfam-B_1042 (release 23.0)	Family	This is a family of short bacterial proteins of unknown function.	30.00	30.00	31.30	31.00	28.80	28.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.18	0.72	-4.44	56	487	2009-01-15 18:05:59	2008-12-03 10:22:49	3	2	384	\N	172	357	10	61.80	30	83.95	CHANGED	hhllhlPhlshlhs.PhhNcscPhlhG.hPFhhaathhWlhloullhhlsaph.................................ttttpc	..........h.hLlllPhlsllh.s.shhNclcPhlhG.hPFhhaa.llWlhloullhsllYhh.........................................................tttt.....................	0	36	94	133
+11588	PF11756	YgbA_NO		Nitrous oxide-stimulated promoter	Mistry J, Coggill P	anon	Pfam-B_1030 (release 23.0)	Family	The function of ygaB is not known but it is a promoter that is stimulated by the presence of nitrous oxide [1]. It is regulated by the gene-product of the bacterial nsrR gene.	25.00	25.00	26.90	26.50	21.30	18.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.83	0.71	-4.05	25	846	2009-01-15 18:05:59	2008-12-03 11:49:24	3	3	813	0	106	453	8	107.60	52	93.30	CHANGED	LsG+LtpEacTlpAMlclYC+pH...Ht..............tsthCp-CpsLhcYAcpRLDRCPYGc.sKPTCs+CPlHCYKPp.+cph+pIMRauGPRMLLpHPIhAIRHLlsE++sVPppsstpsS	.................ss.+RIsREKhTIccMIcLYptcp....p................................uuu.spchcuLhsYApKRLD+CsFG..E...-..KPuCKpCP..VHCYpPupREcMKpIMRaAGPRMLa+HPl.LolRHLlD-..+.+sVPchPpc..+....................	0	26	60	83
+11589	PF11757	RSS_P20		Suppressor of RNA silencing P21-like	Mistry J, Coggill P	anon	Pfam-B_1073 (release 23.0)	Family	This is a large family of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of the major mechanisms of defence against viruses, and, in response, some viruses have evolved or acquired functions for suppression of RNA silencing. These counter-defencive viral proteins with RNA silencing suppressor (RSS) activity were originally discovered in the members of plant virus genera Potyvirus and Cucumovirus. Each of the conserved blocks of amino acids found in P21-like proteins corresponds to a computer-predicted alpha-helix, with the most C-terminal element being 42 residues long. This suggests conservation of the predominantly alpha-helical secondary structure in the P21-like proteins.	23.30	23.30	23.50	24.40	21.70	23.20	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.62	0.71	-4.04	3	159	2009-01-15 18:05:59	2008-12-03 13:32:31	3	1	7	0	0	135	0	143.10	82	81.60	CHANGED	+VGAVs+R........TDsLcphIp-FNsSLAllsAMKsDANoD+hsG+aS.AccKL+lLssIEAplRILLcllRR+llRDcLGlRShpDTFcFhlpKYSSL.ocVPaSEVhRpKlKhVuptVIc-LSREHKLDlSERuFPGa...GIL	............................................KVGuVVERLCDPSVTLTEVMDE.INDFNSFLALVHSMKSDMNGDHQDGHHEMGEHKSRLLCNIEAKLRlLLDIIRRRFTR-KLLCTSATDVhGFFVhRYMSS.SHTSFEoVMRTELKLVV.KAVLS-LSRsHKLDFSERAFsAY...GIL....	0	0	0	0
+11590	PF11758	Bacteriocin_IIi		Aureocin-like type II bacteriocin	Coggill P	anon	Lonsdale D	Family	This is a small family of type II bacteriocins usually encoded on a plasmid. Characteristically the members are small, cationic, rich in Lys and Try, and bring about a generalised membrane permeabilisation leading to leakage of ions. The family includes aureocin A, lacticins Q and Z, and BhtB as well as an archaeal member.	25.00	25.00	25.90	52.70	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.57	0.72	-4.35	5	21	2009-01-15 18:05:59	2008-12-04 11:40:09	3	3	20	0	3	13	0	48.30	59	3.59	CHANGED	MA.aL+ll+alAKYGoKAVpWAWcNKGKlL.-WLNlGpAl-WVspKI++IhGl	..AKYA.......IRYGAKYGKKAVKSGWDYGKKVAKSGWNKGKS...IAQKIPRIHKV.	0	0	2	2
+11591	PF11759	KRTAP		Keratin-associated matrix	Coggill P	anon	Lonsdale D	Family	The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as a result of disulfide bonds between cysteine residues. There are essentially three groups of KRTAPs, viz: the high-sulfur (HS) and ultra-high-sulfur (UHS) KRTAPs (cysteine content: 16-30 and >30 mol%, respectively) and the high-glycine/tyrosine (HGT: 35-60 mol% glycine and tyrosine) KRTAPs.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.58	0.72	-3.72	22	198	2009-01-15 18:05:59	2008-12-04 14:46:09	3	2	24	0	66	249	1	53.40	52	89.57	CHANGED	Ms..YYusY.aGGhGYGh........GaG.GLGhGY.GCGhu................G.u...........................sGYG.....GsGYG.Ga..GYGs........hpP.sYGtY	.......Ms...YYusY.YGGhGYGh...hG.GLGhGY...G...CGhG........h..G..hG.s......t.GaGY......Gs.GaG..GY..GYGs........hts.hhtth...........	0	17	17	17
+11592	PF11760	CbiG_N		Cobalamin synthesis G N-terminal	Enright A, Ouzounis C, Bateman A	anon	Enright A	Domain	Members of this family are involved in cobalamin synthesis.  The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [1]. Within the cobalamin synthesis pathway CbiG catalyses the both the opening of the lactone ring and the extrusion of the two-carbon fragment of cobalt-precorrin-5A from C-20 and its associated methyl group (deacylation) to give cobalt-precorrin-5B [2]. The N-terminal of the enzyme is conserved in this family, and the C-terminal and the mid-sections are conserved independently in other families, CbiG_C and CbiG_mid, although the distinct function of each region is unclear.	25.00	25.00	25.40	26.30	24.90	24.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.57	0.72	-4.28	150	1206	2009-09-10 21:45:10	2008-12-09 13:07:16	3	21	1181	2	319	1016	221	83.40	43	18.54	CHANGED	htshlpphap...p.hcsllhlhAsGIsVRtlAPllp...cKpp.DPAVlVlD-sGpalIsLLuGHhGGANpLApplAphLGupsVITTAo-	............h..phlpphap...p.hcslIhlhAsGIsVRsl.....AP......l.lp...sK.ts.DPAVlVlDEpGpaVIsLLuGHhGGANpLu+plAth...L.....Gu.sPVITTAoD.....	0	108	216	280
+11593	PF11761	CbiG_mid		Cobalamin biosynthesis central region	Enright A	anon	Enright A	Domain	Members of this family are involved in cobalamin synthesis. The gene encoded by Swiss:P72862 has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD, it is therefore possible that CbiG catalyses a reaction step adjacent to CbiH. In the anaerobic pathway such a step could be the formation of a gamma lactone, which is thought to help to mediate the anaerobic ring contraction process [1].	22.70	22.70	22.80	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.90	0.72	-3.75	143	622	2009-01-15 18:05:59	2008-12-10 15:34:47	3	14	614	0	166	505	48	88.40	20	21.68	CHANGED	hhulDhhupt.hGapl...........................sshpshpplsutllsGctl..tlht-........................hh.thphhssp.stp................................................stlhlo....................thttstlhh+P	..........AlDhlApp.hshph.........................................................................................csh.ps.sKplsuhlVstcpVulh.-................................th.ht..h..h..h..p......p.s...phc................................................shlhlo.................h...........h..............................................................................	0	63	122	149
+11594	PF11762	Arabinose_Iso_C		L-arabinose isomerase C-terminal domain	Bateman A	anon	COG2160	Domain	This is a family of L-arabinose isomerases, AraA, EC:5.3.1.4.  These enzymes catalyse the reaction: L-arabinose <=> L-ribulose.  This reaction is the first step in the pathway of L-arabinose utilisation as a carbon source after entering the cell L-arabinose is converted into  L-ribulose by the L-arabinose isomerases enzyme [1]. This is a C-terminal non catalytic domain.	25.00	25.00	26.90	31.50	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.35	0.71	-4.52	38	1016	2012-10-02 11:40:13	2008-12-17 11:58:04	3	3	992	9	186	624	33	114.70	58	23.32	CHANGED	sKPplEVHPLuIGGK-DPARLVFsutsGsAlssSllDhGsRFRLllN-V-sVcPppshPpLPVA+sLWcPpPsLcsuupAWIhAGGAHHTsaShulosEplpDaAchsGlEhllI	........-KPhL-Vp.LGIGG.K.-.DP.ARLlFs.sp.s.G.P.AllASLIDL.G.-RaRLLVNslDsVcss+sLPKLPVApALWKspPsL.TAuEAWILAGGAHHTVFSaALshsphcpFAEhtsIElsVI....	0	60	122	157
+11595	PF11763	DIPSY		Cell-wall adhesin ligand-binding C-terminal	Wood V, Coggill P	anon	Pfam-B_85585 (release 23.0)	Family	The DIPSY domain is characterised by the distinctive D*I*PSY motif at the very C-terminus of yeast cell-wall glycoproteins. It appears not to be conserved in any other species, however. In fungi, cell adhesion is required for flocculation, mating and virulence, and is mediated by covalently bound cell wall proteins termed adhesins. Map4, an adhesin required for mating in Schizosaccharomyces pombe, is N-glycosylated and O-glycosylated, and is an endogenous substrate for the mannosyl transferase Oma4p. Map4 has a modular structure with an N-terminal signal peptide, a serine and threonine (S/T)-rich domain that includes nine repeats of 36 amino acids (rich in serine and threonine residues, but lacking glutamines), and a C-terminal DIPSY domain with no glycosyl-phosphatidyl inositol (GPI)-anchor signal. The N-terminal S/T-rich regions, are required for cell wall attachment, but the C-terminal DIPSY domain is required for agglutination and mating in liquid and solid media [3].	25.00	25.00	71.40	71.40	23.40	18.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.72	0.71	-4.33	4	5	2009-01-15 18:05:59	2008-12-18 10:57:59	3	1	2	0	5	5	0	126.40	31	15.91	CHANGED	NDsIsPSYV.Yh-oN...........G.hhASopGss-G..NlFYYDSTlcRllTCss.RPhYplhp-Ds......souFpIhKssDGp..Fphs.usssE.hcl+l.ssGplahTo..hDscsushss.pshRAssVhLpA	NDSISPSYV.Yh-SN...........GauhASosGss-G.lNlFYYDSTlcRIlTCCsVRPlYplhp-Dst.....uoSFsIhKNuDGs..FTasEuusuEPhcL+lLsDGRlahTSs.hDscs.ushs-.cshRAsNVsLpA	0	4	4	5
+11596	PF11764	N-SET		COMPASS (Complex proteins associated with Set1p) component N	Coggill P	anon	Pfam-B_7375 (release 23.0)	Domain	The n-SET or N-SET domain is a component of the COMPASS complex, associated with SET1, conserved in yeasts and in other eukaryotes up to humans.  The COMPASS complex functions to methylate the fourth lysine of Histone 3 and for the silencing of genes close to the telomeres of chromosomes [2]. This domain promotes trimethylation in conjunction with an RRM domain [4] and is necessary for binding of the Spp1 component of COMPASS into the complex [3].	25.00	25.00	26.00	25.40	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.14	0.71	-4.35	31	286	2009-01-15 18:05:59	2008-12-18 13:08:07	3	12	199	5	190	257	0	151.20	32	11.68	CHANGED	cpphsthhsL.sl..pshlhDcEDhphL+pshpch..t-hs.......NhphWsW+ppphpt.p...tp.s................spp..cpp......h.sthlpssTGsARoEGa+KIscp-KucYLPH+h+sppshpphphcspt.................................ssttp.suppsSRssRussRRhlusIsspp..h...us-SDlL	......................................................................p.pthh.Lhsh...shshDpEDhpaLphsh....cch.......h.tpc.s...s..h...hNsohWla+pt.hp.th...........................................pp..ppp......hpsthhppsTGsARoEGah+Iscp-Ks+YLspph.hspptt-p.tspspt...................................sspsp.ssppsupppRuppRRLluslssp.......usD..SDLL....................	0	43	78	141
+11597	PF11765	Hyphal_reg_CWP		Hyphally regulated cell wall protein N-terminal	Coggill P	anon	manual	Domain	The proteins in this family are all fungal and largely annotated as being hyphally regulated cell wall proteins, and several are listed as the enzyme EC:3.2.1.18. This enzyme is acetylneuraminyl hydrolase or exo-alpha-sialidase, that hydrolyses glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.	25.00	25.00	28.60	35.30	22.80	24.60	hmmbuild  -o /dev/null HMM SEED	332	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.93	0.70	-5.68	8	149	2009-01-15 18:05:59	2008-12-19 16:57:30	3	11	20	0	117	153	0	315.40	33	36.77	CHANGED	llslhhllssshAlsITps+VDRGslsLslGDITIpuGuaWSIIDNulosFsGsLpVpsuAGLYIoSTSsLLALQVTLsShLuSIpNsGlIoFNShsSLTuosYsLlGlSFsNsGEMYLuASG.shssshulTuuoWoNsGLLsFYQNpRooGsVSLGsPhGoIsNNGQICLaNclYpQTTpIsGoGChTANpsSoIalSNsLLslsosQsFYLADSpSSlhspAlSsspTFNVYGFGNGNpIGLsLPLlu.s.hssAYsYDsoTGILTLR.sGhLuQcFNIGhGYssuhFpIVTDsusGLsSs.hGuloYSGPVPsRsLPusCQ.PCKPlPsuP	..........................................................................h..hhhhht..hh.u...h.pls.p.spl..shGsh..shsh..G.Dl.pIpsG.uhaSIl.sN...s...h....ssahGsl..pVppsuuhYIooss.s..h.l.uLpVs...l.h......s.hhts..lpNsGllsh.suh.p.ohs.ussasl.hGh..o.FpN..sG..-hah..uu..sG....hs..ss.s.hs...l...s.u.s.s.W...pNs..GLlsa.aQ..s.p.+..o.s.....Gs.....l.p.L..G.t........s.......h....s.....oI...sNsGpICLpNps.apQ.s.o.sIpG.oGClo..sspsSsl..a..l....sN..s.hh...s..lsssQshYLssspS..Sl.h............s..p.uh..u.s....sp.Ta..pVhGFG.....N.....G..N+..I...GL.......shsL..h...s......h.................ssasYsssoGILTL.......p......s..sh.........h..s.pp...FsI....GhGY-sshF.p.l.s.o.D.s.ut.Gl.sshhGu..lpYsGssPs.t..sh.Ps..Cp.sCpshPthP........................................	0	12	44	117
+11598	PF11766	Candida_ALS_N		Cell-wall agglutinin N-terminal ligand-sugar binding 	Coggill P	anon	Candida_ALS	Domain	This is likely to be the sugar or ligand binding domain of the yeast alpha-agglutinins.	25.00	25.00	28.10	27.70	20.00	18.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.73	0.70	-5.47	24	165	2009-01-15 18:05:59	2008-12-22 09:42:18	3	36	42	5	84	174	0	240.80	38	24.30	CHANGED	sWsl.DGsssssGDTFTLpMPsVFKFpss..psolpLss....ssssYAoCsh.sG-hhssaSpLpCosssslss..spps.GolshPlsFNsGGSusssDLpsuppFsuGsNTVoFsDGspplSsoVsF-uus.......ssssshlhtuRhsPolsphphahluspCsNGYsSGs...lGaossss..tlDCSslpstIosplNDWhaPpoucs.hsaohoCousu..lhIoapN.lPAGYRPFl-uhh...sssssshphsasscYpC	......uWsl.DGossssGDTFTLsMPCVFKFpos.....psolsLss......sussYATCshpsG-.hssaSoLpCTlss....slss..stpAhGolohPlsFNlGGSusssDLps.SpsFsuGsNTVoFsDGs...pplSssVsFpsss..........ssssshl.h..tuRhhPolsc.hps.hhluspCsNGYpSGs......lGas..ss..ss....sssID.CSslclu..Io..NslNDW.aPh.oucs....hoaohoCousu..lhIoapN.lPAGYRPFlDAhl....sss..ss..shshsYpNpYsC...........	0	10	23	82
+11599	PF11767	SET_assoc		Histone lysine methyltransferase SET associated	Coggill P	anon	Pfam-B_8752 (release 23.0)	Domain	SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. A subset of SET domains have been called PR domains. The SET domain consists of two regions known as N-SET and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance.  Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure [2]. This domain is found in fungi associated with SET and N-SET domains.	21.00	21.00	21.10	45.10	20.10	20.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.16	0.72	-4.66	20	114	2009-01-15 18:05:59	2008-12-22 13:49:53	3	4	113	0	88	118	0	69.40	38	5.99	CHANGED	aIsccaVPspssosp-lK+pL+pYsWsclhs-+oGaYIlFsshc....EAc+CapspsspthFsac.....hhMc	..FIu+paVPlhssolsHlK+RLKtasacclR.sD+TGaYIlFpsoc.G...p.EsERCacssstpthFsYp.....MsMc...........	1	15	43	75
+11600	PF11768	DUF3312		Protein of unknown function (DUF3312)	Mistry J	anon	Pfam-B_5984 (release 23.0)	Family	This is a eukaryotic family of uncharacterised proteins. This family shows similarity to WD40 repeat proteins.	26.20	26.20	26.20	26.20	26.10	25.20	hmmbuild  -o /dev/null HMM SEED	545	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.81	0.70	-12.64	0.70	-6.28	7	103	2012-10-05 17:30:43	2008-12-22 14:09:06	3	6	72	0	71	106	0	404.70	39	68.62	CHANGED	KppasEuRGh.Wol+N...K+Pp+LRDsLKcLEEhLppppslhs+W+sphhhQLhhusGlLlp..ls..sspLp+VhhD+.LVGKLhu-pIoDAllTcoaIllSa.spNplshVpLpK.sshs....ppLEKlShhD.KIpas.I...PGsssR+lsR+LslNupQ-lslsWhtssps-V.aPWpPssp-pDRANlhlhphsus.pLElLsYhhTEhDPlsVpFSh.psaQlhTVEpplutps-...shhDsCIYEhs+sKhcRVuVTpIPLpoplsssAhsssc-KLhLGC.DuSllLaDttRtlThLs.pAslhPshluWHssuullhVusppGpLQsFDlALuslphQLluE..-stPpusLpLppaF....sss.sLsclpWu.tP.lspptcshspssshLhLhF-pGPLuslphhhGshh+GpltsstLhu.....pYI+hsQV-cAlslLtShNWsThGt.ChhuhptIsNalh+t.Lss-REsQLEtsLGoFhsPs+PLs-pThLEapD.VschsRRFFHaLLRhppFpKAF.LAlDIsstDLFMDlH.lAtshG-lsLAc.A	.........................................................................................K.ph.pt...Rsh.hh.cN...+pst+L+csL+.lE-hhpppphlhspWpst....h..lhhssGllhp..ls..sspl.phhh-+.LhGKL..p.lsDshhoppallhsa.tpsplshl.hp+..t........pt.-Klu.h-.+l.hh.l...sG.s..s+phtR+LslNt.tDhh..lsWh..sp..s-s.aPWtP.h.p-p-RANlhlhthtth.pLElLs.hhTEhsP..lsspFs.hpps.plhTlEppluhct-..........s.s-.ChYEh...........s......p.s...K.hp.p.h.......ulTpl....Pltopshssshsssc-+LlLGC..D.uolhLa-............hpp..sTh...hs.ps.......t.ll.........PshluhHssuullhVusppGpLQhFDhALuslphQLluE...sh.Ppph...Lphs..phF......thp.sLhphpW..ts.h...t.t.sph..shL..hLhacpGP..luslhhhh.GhhhpG..plt..tlh.......pYl+hsph.cAlslLtuhNWsT....h.Gt.ChhshptIs.NaLh+t.LsspREsplEtsLGsFasPs+PL.-ssh.EapD..lpchsRRFFHaLLRhphatcAF.lA.DltshDlFhp.......................................................................	0	29	34	52
+11601	PF11769	DUF3313		Protein of unknown function (DUF3313)	Mistry J	anon	Pfam-B_1303 (release 23.0)	Family	This a bacterial family of proteins which are annotated as putative lipoproteins.	20.70	20.70	21.50	20.70	20.60	20.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.00	0.71	-4.95	64	738	2012-10-02 17:45:13	2008-12-24 10:50:44	3	4	658	0	152	414	39	195.50	44	87.44	CHANGED	lhluGCuus.sp.......uuhlss...astLppsp...sstsshpahssshc........hspYsplhl-Plph...............h.t.spsshp.lsp.psh....pplssahsptlppplupp..hpls..spP.uPsslhl+sAlTslssss.slpsh.cllPhuhlhsssptu....sGtpstssplshEsclhDusoscllutsVc+ttupsh...stsspsh.shsss+ssl-paApchsp	...........................LALoGCASKlspP-p..............YSGFLss...YScLpEoTS.AoG+PlLRWVDPsac........tSp.YD.s.IlasPlTY......................YPs.PKPoo.Q.V.uQ...psL....-clLsYsNschKcAIupR....pPLV.....TTs..GP+oL..IhRuAITGVDTSK......E....G....LQFY....EVlP....VA.LlVAGTQhA.............TG+RTMDTcLaaE..uELIDAATNKPVlKVVRpGp.GpcL.................sNpoTPh.u.h-slKpVlD-hAsDs..p..............................................................	1	30	68	109
+11602	PF11770	GAPT		GRB2-binding adapter (GAPT)	Mistry J	anon	Manual	Family	This is a family of transmembrane proteins which bind the growth factor receptor-bound protein 2 (GRB2) in B cells [1].  In contrast to other transmembrane adaptor proteins, GAPT is not phosphorylated upon BCR ligation.  It associates with GRB2 constitutively through its proline-rich region [1].	20.80	20.80	22.60	21.10	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.96	0.71	-4.55	3	26	2009-01-15 18:05:59	2009-01-05 11:29:25	3	2	23	0	15	20	0	149.50	60	96.31	CHANGED	MLKsCGNosVAVSVGISLLLLLVlCGIGCVWHWKHRsoTRFTLPKFLQRRSSR+KDsTKTFSLSPplIGPRHKsSVETQDHKSAuKcNNhHDNYENVEVCPPKAKGcTDKcLYENTtQSNhEEHIYGNETssDYYNFQKPSPSEsPQDEDIYILPDSY	.....MLKSCGNs.sAISVGISLLL.LLVlCGIGCVWHWKH...+suT.RFTLP+FLQRRSSR.+K.ssTKTh.LuPclIG.+HKhSVcTpDH+Sus+ssslHcNYENVEsGPP+sKtcTDKELYENTpQoNFEEHIYGNETuS-YYNFQKPpsScsPQDEDIYILPDS...	0	1	1	3
+11603	PF11771	DUF3314		Protein of unknown function (DUF3314) 	Coggill P	anon	SwissProt (UPF0575)	Family	This small family contains human, mouse and fish members but the function is not known.	25.00	25.00	150.50	42.80	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.41	0.71	-4.48	3	44	2009-01-15 18:05:59	2009-01-05 12:59:39	3	2	29	0	22	33	0	150.10	65	57.07	CHANGED	MFASFuFssLEE.sPLSVSHFuIGQssIc.uh+VSIFRYCsPTPYLASuhTG.LYK+MRWNVEtssEusGcGcsaDu..........SlsEYYFLCYEDThEsAc........EutsossDSsuclsRlWSIGRWVpotPpssTDDllDWlLCPlPsGsYKQLLsLG.EEPSSshATDLLVQlL	...MYASFGFVsLEETsPL....SISCFFCGRFSIS.SH.-VSIFRYCsPsAYTAS+FPRYLYKKMRWNLEsTs.E.ssupGp-.............ShVDYYFLCYRDTWE............DsGpoPAN..SCPQIQKLWSIGRWVPLGP...s.-DDLhSWILCPQPsGDYQQLLTIGFEEPSphLATDLLVQlL.............	0	1	3	7
+11604	PF11772	EpuA		DNA-directed RNA polymerase subunit beta	Mistry J, Coggill P	anon	Pfam-B_4675 (release 23.0)	Family	This short 60-residue long bacterial family is the beta subunit of the DNA-directed RNA polymerase, likely to be EC:2.7.7.6. It is membrane-bound and is referred to by the name EpuA.	21.30	21.30	21.60	23.40	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.24	0.72	-4.52	20	529	2009-01-15 18:05:59	2009-01-07 11:27:24	3	1	523	0	56	207	0	47.00	48	72.40	CHANGED	lll.VllLhllsLslGLMlGYullGsG.sPhslLp.cpWpcIlshhptp	........lll.VllL.uhLsLslGLMlGYGllGcG.sPauILSPspWpcllpKFTGp...	0	14	30	42
+11605	PF11773	PulG		Type II secretory pathway pseudopilin 	Mistry J, Coggill P	anon	Pfam-B_4690 (release 23.0)	Family	The secreton (type II secretion) and type IV pilus biogenesis branches of the general secretory pathway in Gram-negative bacteria share many features that suggest a common evolutionary origin. Five components of the secreton, the pseudopilins, are similar to subunits of type IV pili. Pseudopilin PulG is one of the secreton pseudopilins, and is found to assemble into pilus-like bundles [1]. PulG interacts with proteins H, I and J within the multi-protein complex as well as blocking extracellular secretion and reducing the amount of PulE protein as well as the amounts of PulL, PulM, PulC and PulD when G is over-expressed [2]. In Klebsiella the pilus-like structure is composed largely of PulG [3].	25.00	25.00	28.90	28.90	22.30	20.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.44	0.72	-4.25	9	340	2009-01-15 18:05:59	2009-01-07 11:56:40	3	1	333	0	23	146	0	79.20	58	88.03	CHANGED	ILLESLlAlAlLssIsoLlLoplspsRpctspphpppElLslApMAlQTpQccLolNGlsIplpcopptlhlacpucEllcl	.ILLEAlVALAIFASIATLLLGQIQ+NRQEEAclLQKEEVLRVA+MALQTGQsQloINGVEIQVhuSEKGLEVYHGoEpLLuI....	0	1	5	13
+11606	PF11774	Lsr2		Lsr2 	Mistry J	anon	PD026347	Family	Lsr2 is a small, basic DNA-bridging protein present in Mycobacterium and related actinomycetes.  It is a functional homologue of the H-NS-like proteins [1].  H-NS proteins play a role in nucleoid organisation and also function as a pleiotropic regulator of gene expression [1][2].	21.00	21.00	21.30	21.00	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.38	0.72	-4.14	69	720	2009-01-15 18:05:59	2009-01-07 13:29:32	3	16	402	5	243	584	10	101.80	37	66.89	CHANGED	MAcKVhVp..LVDDlDG.utA-...ETVpFuLDGVsYEIDLSscNAs+LRpsLp.alssuRRlG...ut....c+ut....................sssps.pssts+cpsssIRcWARpNGapVSsRGRIPu-ll-AYctA	.............................................................................................MAp+hhl..pLlDDlDG..s.A-....-oVpFuL..D..GhsYpIDLospNA.pcLRp...s...Lt.a..lttuR+su.tp.......................................ttsts...pssssptpsstlRpW....A+p.sGap......V.....SsRG..RIss-lh-AYctA........................................................................................................................	0	94	195	223
+11607	PF11775	CobT_C		Cobalamin biosynthesis protein CobT VWA domain	Bateman A	anon	Pfam-B_10956 (release 9.0)	Domain	This family consists of several bacterial cobalamin biosynthesis (CobT) proteins. CobT is involved in the transformation of precorrin-3 into cobyrinic acid [1]. 	20.10	20.10	20.10	20.10	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.29	0.70	-4.92	2	462	2012-10-10 16:07:06	2009-01-07 13:44:22	3	6	430	0	134	465	1894	195.60	50	32.61	CHANGED	sFh+cc-tphhsssVp.llD.SGSMtGR.IplAhssA.hlAcsL-RhsV.s.IhGFTTh...Gu.shEsh.ttGhst..uhh.slh+.h.cpAsuP.hRAR..hGhhhcph.LhpNlDGEuls.htphhhGR.Ep+KIhhhhSDGAPs.......sAGshhcpHLRplhcEIEThS.l-LhAIGlhpDssR.YY+phshlsssEELGsulspcLuclh.t	...........................................saKpE+-.scF+DTVVTLLlDNSGSM.R......G......RPI....slA.AhsADlLARTLERC.G.VKlEILGFTT......+....A......W.K.G...G.p.u.REtWltt....G..+..P......t.t..PGRLNDLRHIlYK..s..ADsPWRRA....RpsLGLMh+.EGLLK.ENIDGEAL..WAapRL.huRsEpR+.ILMlISDGAPVDDSTLSsNsus..YLEc.HLRtV.I....ptIEs.....+u.sVE..L.lA..IG.I..G..H....D...V...TR...YY..p..+.AVTIscs-pLuushhppLutLF..p........................................................................	0	34	83	104
+11608	PF11776	DUF3315		Domain of unknown function (DUF3315)	Mistry J	anon	PD456999	Family	This is a Proteobacterial family of uncharacterised proteins. Some of the proteins in this family are annotated as being putative membrane proteins.	23.30	23.30	23.40	23.60	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.49	0.72	-4.44	112	1010	2009-01-15 18:05:59	2009-01-07 13:51:14	3	4	799	1	169	569	18	51.00	42	38.50	CHANGED	Gc+lP.spYRsc.pYslcDW+tapLssPs+Gh+Wlths.GcYlLlshuoGlIlpl	................G-plP.phYRsc.cYsIcpWp.h+.s.LPAPstG..p+WshhG..GsYVLIssssGpIlc.........	0	21	61	115
+11609	PF11777	DUF3316		Protein of unknown function (DUF3316)	Mistry J, Coggill P	anon	Pfam-B_4718 (release 23.0)	Family	This family of bacterial proteins has no known function. Several members are, however, annotated as being putative acyl-CoA synthetase, but this could not be confirmed.	24.40	24.40	24.40	24.50	24.20	24.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.35	0.71	-4.31	23	216	2009-01-15 18:05:59	2009-01-07 14:36:55	3	1	189	0	28	150	0	126.10	28	67.67	CHANGED	MKplhlls.....hhlhhussuhA...............shtpp.pspolpssshso+psAYsh........Ghshlpshptpos....ppLstcLplhsp..hshpsh+lpD.upVoVpchhpss...............GplpYpshlclcac.....................YphRsuN	..............................................................Kphllhh.....hhlhhu.ssuhA...............th..t.pscol.p.us.hhsoppphY.us........Ghspl.ph.h.Pp....phhup-Lpl..hpp...hs.+s.s+lps..spVs.VQphhpts...................GhlpYpshl+hsap................................YphRpoN.............................................................	0	4	14	24
+11610	PF11778	SID		Septation initiation	Wood V, Coggill P	anon	Pfam-B_41015 (release 23.0)	Family	This family is required for activation of the spg1 GTPase signalling cascade which leads to the initiation of septation and the subsequent termination of mitosis. It may act as a scaffold at the spindle pole body to which other components of the spg1 signalling cascade attach in pombe [1,2,3]. In S.cerevisiae it is both required for the proper formation of the spindle pole body outer plaque and may also connect the outer plaque to the central plaque embedded in the nuclear envelope [4].	25.00	25.00	27.80	25.80	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.72	0.71	-4.27	9	50	2009-01-15 18:05:59	2009-01-08 14:46:36	3	1	38	1	31	52	0	130.50	28	20.46	CHANGED	slpplpGNssphlT.-sltpph.phs+Ep..YssLtl-plDplshVphQNhlKslllhLcIPasKLpp+lPLluIpLpaEpphLhpFANpLHhhlYsc.lshKphTp.Ahs-alps+shtplcHPLc.CL-sLacpltpp	........................htpl.Gssuptlshcsltpsh..clspcp...YspLtl-plDslshlpLQNllKslllhltIPatplhcplPhlsIpLphEhtlltpFsscLHhplYs..pphshK...p...hss...Ahppahps.pp.hsplcH.Lc.CLptLacplh..t...................................	0	6	18	30
+11611	PF11779	DUF3317		Protein of unknown function (DUF3317)	Wood V, Coggill P	anon	Pfam-B_3618 (release 23.0)	Family	This is a short family of proteins conserved from fungi and plants to human. One each of the human and mouse members is annotated as being androgen down-regulated protein expressed in mouse prostate, with a potential signal transduction function, and all appear to be membrane proteins.	25.00	25.00	25.00	25.50	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.71	0.72	-4.53	27	282	2009-01-15 18:05:59	2009-01-08 14:49:58	3	3	177	0	194	250	0	56.70	29	53.89	CHANGED	thtcalphhhapYplThulYhls.PhE+hlhNshl....hhllthllhuhhha....lPspltthhp	........h..hpalphhhYpYplshulYML-.PWE+hlF......Noll....lslluhlla.ssala....hPpalhhhh.t................	0	44	78	133
+11612	PF11780	DUF3318		Protein of unknown function (DUF3318)	Mistry J	anon	Pfam-B_1341 (release 23.0)	Family	This is a bacterial family of uncharacterised proteins.	22.30	22.30	24.30	23.80	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.67	0.71	-4.63	18	198	2009-01-15 18:05:59	2009-01-08 14:52:58	3	1	158	0	68	175	98	138.50	29	75.94	CHANGED	hp+LpshhPsuhRhplhls.Apscptpllpuhh.h....sptphhlshshWhshshspRslhhh+psuhhps.......ppa.tlshh.ulslsGhhssslphsptcsltlslAuGLuuhushplWppspu...spsplsADp.tAlchAscpGY	.......h.pcLpshhPhtlRp.lhlhtusspp.pLhpstt.hR.....splphhhsLpha.shs.hspRsLhhh+p.suplps..................spaPh.uh.h.uhlhhGhstulhchhspcuLthshAlGLuuhtuYRlWppspu....ctshtADt.tA.t.u.c.........................	1	11	37	56
+11613	PF11781	RRN7		RNA polymerase I-specific transcription initiation factor Rrn7	Pollington J	anon	Pfam-B_4705 (release 23.0)	Domain	Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [1,2]. 	23.30	23.30	23.30	23.30	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-8.02	0.72	-4.45	25	186	2012-10-03 10:42:43	2009-01-08 17:32:32	3	6	161	0	119	197	6	34.60	32	6.39	CHANGED	hphh.cs.t..Cuh..Cput....hhhsc-GhaaC.pCGsht-	..........h.ct....Csp..Csup....hhhtc-GthaC.psGphhE...	0	24	50	90
+11614	PF11782	DUF3319		Protein of unknown function (DUF3319)	Coggill P	anon	Pfam-B_4745 (release 23.0)	Family	This is a family of short bacterial proteins, a few of which are annotated as being minor tail protein. Otherwise the function is unknown.	25.00	25.00	28.40	46.60	19.40	22.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.06	0.72	-4.18	9	129	2009-01-15 18:05:59	2009-01-09 10:19:37	3	1	128	0	20	64	2	77.90	55	71.29	CHANGED	MtpslY.RGa.LpsusussshW+spIKs+llpGsLsAVKKSIDWWhDTuolIDP+EFsulsppp...tsouspoEsapGapIKNDTGEPNtW	.Mth.hY.pGF.Lpsstspsp.WplpI+sp.hsGsLuAVKKSIDWFCDTASIIDPKEFpSlGpK+...psuuuspEpFNGaTIKNDTGEsNcW.....................	0	2	5	14
+11615	PF11783	Cytochrome_cB		Cytochrome c bacterial	Mistry J, Coggill P	anon	Pfam-B_4681 (release 23.0)	Family	This is a family of long bacterial cytochrome c proteins, found in Proteobacteria and Chlorobi families.	21.00	21.00	21.10	22.90	19.30	20.80	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.46	0.71	-4.70	41	134	2009-01-15 18:05:59	2009-01-09 14:18:37	3	13	96	1	78	132	23	171.90	31	31.52	CHANGED	KhhWDWSpAGp..........................p.....t.sp.sahppKGsF....patc.sltPpYtWaNG.phphhhhs-tlc.s.............sps...ltlstPhGshsDst.u+IaPFKlapG+QPYDtptppllsscha..G.................tuhWss.....aDaspAlptGhc.............................................ts......Glta.....SGca.....................................sFlcTphaaslsHhVuPK-cA.L..pCs-CHspsuc	.........................................ch.WDWupAGp.t................t....................tt.sp.sY.thKGsFtatc.slhPtYtWaNG.phph.hhhs-ths..s...............sts....splstPhGshsDsp.u+IaPFKlapGcQsaDttpppllss..cha.................t...suaWps.....aDaspAlptGhc...................................................ts......Gl.a.....SGca.................................................................................................sFlcTphaaslsHhVuPKc.cA.L..sCs-CHssss....	0	23	48	71
+11616	PF11784	DUF3320		Protein of unknown function (DUF3320)	Coggill P	anon	Pfam-B_4770 (release 23.0)	Family	This family is conserved in Proteobacteria and Chlorobi families. Many members are annotated as being putative DNA helicase-related proteins.	25.00	25.00	25.20	26.00	22.10	24.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.52	0.72	-4.44	41	216	2009-01-15 18:05:59	2009-01-09 14:23:31	3	10	211	0	81	219	9	51.20	28	3.04	CHANGED	ssthhpts.pshLtphlpcllphEGPlpcshLscRltpuaGhpRsG....sRIppt	.........t.hptp.tshLtphlppllcsEuPIppshLspRltpuaG.lpRsG....s+lcp...........	0	28	46	61
+11617	PF11785	Aft1_OSA		Aft1 osmotic stress response (OSM) domain	Mistry J, Finn RD, Wood V, Wahls W	anon	Manual	Domain	This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The OSM domain has been shown to be involved in the osmotic stress response [1].	21.60	21.60	22.00	22.00	20.80	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.01	0.72	-3.43	10	122	2009-01-15 18:05:59	2009-01-14 09:32:12	3	6	114	0	86	120	0	51.10	40	9.37	CHANGED	sosu-.sspuLAPPsRsusptp.......ssTPDYFuulps..shuLEPNPFEQSF......Guuss-......TP	...................................s.............s.p.s.............ssss.shhst.ts.....shsLEPNPFEQSF.........Guss.-...s................................	0	23	45	72
+11618	PF11786	Aft1_HRA		Aft1 HRA domain	Mistry J, Wood V, FinnRD, Wahls W	anon	Manual	Domain	This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The HRA domain is involved in meiotic recombination.  It has been shown to be necessary and sufficient to activate recombination [1].	25.00	25.00	25.00	26.50	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.77	0.72	-3.72	5	90	2009-01-15 18:05:59	2009-01-14 09:44:44	3	6	87	0	65	91	0	79.20	61	14.87	CHANGED	PuuusP..asW.usuSLRoG....PLSPAMLsGPTG......SsDYFSssu+hpu........GFPTPNESSLRTGLTPG.GuG.............SMFPAPSPNTQAlLsp	............sso..suss..asW.........ssSLRoG....PLSPAMLuGPst......ssDYFssht+..............GFPTPNESSLRTG....LTPG...GuG........................SMFPA.P.SPNoQAlht.................................................	0	16	33	52
+11619	PF11787	Aft1_HRR		Aft1 HRR domain	Mistry J, Wood V, Finn RD, Wahls W	anon	Manual	Domain	This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses.  The HRR domain is involved in meiotic recombination.  It has been shown to be necessary and sufficient to repress recombination [1].	25.00	25.00	34.60	33.50	19.20	22.40	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.47	0.72	-2.93	9	76	2009-01-15 18:05:59	2009-01-14 09:46:02	3	4	72	0	57	73	0	75.40	49	14.56	CHANGED	uATPuTI-FHRTAlsAA...................cpss..usTSpP.pstsptsp....sshshpPsps....PFs.HDssDAANGLaMLApGs	....GATPoTlDFHRTAlsAA.........................pp.....s.....t.............u...sT...SpP.p-.sst.hpt......sph-hcssss.....PFs.HDssDAANGLFMLApGt.	0	9	26	45
+11620	PF11788	MRP-L46		39S mitochondrial ribosomal protein L46 	Wood V, Finn RD, Coggill P	anon	Pfam-B_1897 (release 23.0)	Family	This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.	21.90	21.90	22.70	22.10	20.90	21.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.41	0.72	-3.40	37	276	2009-01-15 18:05:59	2009-01-15 13:02:55	3	6	247	0	192	272	0	110.20	24	36.02	CHANGED	hplpuullLpR.PllotchsshEppa..a.........pcL.c+l.hpasphhhachsohs-h.ca.t.ptp.hppp.t..h..sh.ph.tpphpcp.cpplt.........................................pPssRlT..-AD	..........................clhuullLpR.PllopplsshEppa............pcL.c.plphphsth..achts.t-......ch.....ptph.h.pp...p..............s.tth.h..hp.......pht.p.c.thtt..............................................................pPtsRhTcAD.......................................................	0	54	98	153
+11621	PF11789	zf-Nse		Zinc-finger of the MIZ type in Nse subunit	Wood V, Coggill P, Finn RD	anon	Pfam-B_1696 (release 23.0)	Domain	Nse1 and Nse2 are novel non-SMC subunits of the fission yeast Smc5-6 DNA repair complex. This family is the zinc-finger domain similar to the MIZ type of zinc-finger [1].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.23	0.72	-4.45	22	399	2012-10-03 15:03:13	2009-01-15 16:14:09	3	17	271	2	265	1659	117	59.30	29	18.81	CHANGED	D-ltlpp..sphsLpCPlThpshcpPVps+.........pC.sHsFE+puIhphl.....................pptppscCPl.uCu	........................................-l.hpt....t....hshpCP.lT...tt.......h...c...p...P..Vpsp........................pC...sH..s..a.-+.c.uI..hphl.............................................p.p..p..pp.h..pCPhhGC............................................	0	102	155	226
+11622	PF11790	Glyco_hydro_cc		Glycosyl hydrolase catalytic core	Wood V, Coggill P, Finn RD	anon	Pfam-B_1680 (release 23.0), IPR013781	Family	This family is probably a glycosyl hydrolase, and is conserved in fungi and some Proteobacteria. The pombe member is annotated as being from IPR013781.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.93	0.70	-4.94	51	454	2012-10-03 05:44:19	2009-01-15 17:13:44	3	34	246	0	280	584	106	211.60	20	50.29	CHANGED	Gluas......sss.........spth....ttsusloWh.YNWs.hssushsst.........EFVPMlWGsp.st.......shhsslpss..............tsspalLuFNEPDh..ss...QushsP.psAAphahphhpP........tss+lsuPul..ssu..........sh......WhppFhss...Cs..................sC......plDalulHaY.......ss.sss.hpsalsphhstas........cPlWlTEFu..t..........sssssppp....pppFhppslsal-sp...shVpRYuaFs.............s..ssssstLlstp......G.sLTslGphY	....................................................................................................................................................................thsWh..Ysat.......................palPh..has.t..........t.htt.h.th.....................t.phlh..sa...NEPDh....ss..........tush.ss..ttAstha...phh.t.s.................thpls....uPuh..sss.........shs.........W.l.p..p.Fhps...sp.....................ss......phDalslHaY..............................tss..hps...h..hs...hl...pph....h...s...t.as......................cPlWlTEau.......................................stsstpp.............ttpa.hppshs..hh.-t..t............shV.t+Y.uaFt..........................hhp...t...........u...tho.hG..a..................................................................................	1	99	179	242
+11624	PF11791	Aconitase_B_N		Aconitate B N-terminal domain	Bateman A	anon	Pfam-B_2605 (release 10.0)	Domain	This family represents the N-terminal domain of Aconitase B.	21.70	21.70	21.70	25.90	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.91	0.71	-4.40	94	1508	2009-05-07 16:09:31	2009-05-07 17:09:31	3	5	1476	2	324	1082	761	149.10	63	17.65	CHANGED	sY+pHltER.us..GlPPhPLs.A-QTupLlELLKsPPsu.-cc..................................aLL-LLppRVPPGVD-AAaVKAuFLsuIspG-sssslIottcAlcLLGTMhGGYNlpsLl-hL....cDsc.................lAstAAcsLppTLLlaDA.FcDVt-hucs.NsaAKpVlcSWAcAEWF	.....tYR+HVtER....A.A...GIsPhPLs.ApQsAsLVELLKN.PPsG...EE-..................................FLLDLLpNRVPPGVDEAAYVKAuFLAAlAKG....-spSPLlo.........sc+AlELLGTM.GGYNIcPLI-hL....DDsc..................LAslAAcALp+TLLMFDs.FaDVpEKAKAGNta....AKpVlQSWADAEWF.....	0	75	179	264
+11625	PF11792	Baculo_LEF5_C		Baculoviridae late expression factor 5 C-terminal domain	Bateman A	anon	Pfam-B_5141 (release 7.6)	Domain	This C-terminal domain is likely to be a zinc-binding domain.	20.30	20.30	20.30	20.30	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.38	0.72	-4.57	24	63	2012-10-03 10:42:43	2009-05-07 17:12:19	3	2	61	0	0	99	2	42.90	50	16.91	CHANGED	pLpslNGholct.C.pHcal..shE+QhRAGDEhVSFI+YCphCshh	................L.slsGhoL+t.C.pHcFl..T.lE.+QhRAGDEhVSFI+YCphCsh.h.	0	0	0	0
+11626	PF11793	FANCL_C		FANCL C-terminal domain	KOGs, Finn RD, Coggill P	anon	KOGs (KOG3268)	Domain	This domain is found at the C-terminus of the Fancl protein in humans which is the putative E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.86	0.72	-4.01	10	241	2012-10-03 15:03:13	2009-05-07 17:18:36	3	10	152	2	176	501	25	65.60	32	9.50	CHANGED	tph-CGICaAYRL.........sGplP-hsCDNP+Cup.FHpsCLhEWL+oLhsSRQSFslhFGpCPYCsc.lolcho	....................-CsIC....a.uh.h.h..............................ss..sl..P.c...hs..C...cs.pCsphFHpsCLhc...Wh...pu.....t....s...o...p...p..........h.........h..G...p...CPhCpp.lt....h....................	0	50	77	128
+11627	PF11794	HpaB_N		4-hydroxyphenylacetate 3-hydroxylase N terminal	Bateman A	anon	Pfam-B_3148 (release 6.5)	Family	HpaB Swiss:Q57160 encodes part of the 4-hydroxyphenylacetate 3-hydroxylase from Escherichia coli [2]. HpaB is part of a heterodimeric enzyme that also requires HpaC. The enzyme is NADH-dependent and uses FAD as the redox chromophore. This family also includes PvcC Swiss:O30372 may play a role in one of the proposed hydroxylation steps of pyoverdine chromophore biosynthesis [1]. 	30.00	30.00	30.50	43.10	29.10	29.60	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.52	0.70	-5.00	80	1009	2009-05-07 16:38:44	2009-05-07 17:38:44	3	4	755	14	223	742	285	248.40	39	52.63	CHANGED	TGc-Yl-SL+.ct+..pVYltGE+V.t.-VssHPsh+sslpuhAphYDht...a...........cschp-......hhThhospsup.tssphaplscot-DLht+pchhcthuchotG.hh..sR..usDhhsuhhsshtst..chaus.............atcshpcahchsp-pDLhhstAhssPpsDRu...pss......pps.Dlhl+VVccs-c..........GIlVcGAKhhsTuushocplhlhshts......h.stt-...c-aAlsFulPhssPGl+hlsRpuhpsstt....ssaD.Pluu+a-..EtDulllFDcVhVPWE+VFh	.................TGp-YlcSLp..-s+..clYlhGE+Vc..DVosH........P......uFRsuhtolAplYDhh.a..........csph..p-..........hhshs..ospsut.hsp+.a.FchscSs-DLhppRcuhtpWu+ho.h.G.hhGR....oPDahsuhhsshtsss.thaGp.............atpNhcsaYpchp-ssLhhsHAllsP.hDRp...css.........pcstDlal+l.cEs-s..........GIlVSGAKslATsusloc..hlh.sss.........hhscs....tDaAlhFssPhDu.GlKlIsRtuap.sssh...tosaDaPLSSRF-..EpDAllVhDcVhIPWEpVhl....................	0	83	142	186
+11628	PF11795	DUF3322		Uncharacterized protein conserved in bacteria N-term (DUF3322)	COGs, Finn RD, Sammut SJ	anon	COGs (COG4924)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. The family represents just the N-terminus.	21.60	21.60	21.60	22.00	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.05	0.71	-4.65	30	182	2009-09-11 10:44:22	2009-05-07 17:43:26	3	3	174	0	63	162	20	178.50	24	46.76	CHANGED	PsDl+tpl.pRhWccuplhtuhhts..pshaPhpLsL+sPsupplupchs.pVRcWl.pplpss........ups.......clcW+plsaRh.hGpsplPsclhlcohpcAlsllG+p.....pphpp.acthlphspsphPpLlshltpcPhpsl..chustW........spllsllcWhppHscsGlYLRplslsGV.coKFlE.p++ulLscLLDl	.................................................plttpl.t+.apptphhtthhhs.......tsh.aPh.p..lslthP.sstthstphp..sl+pal.pshpph...........utt......plcWcphph+h..hu.ssplPsclhlss...s....phlshhGcp......tchpp..hp....phhtt.httphs.t...Lht.h..h.........thh....phtpth................thtpllsllpalpt.p..ss.sGh.h...lRplslsGl.DoKalE.p+pullspLls..................	0	22	46	60
+11629	PF11796	DUF3323		Protein of unknown function N-terminus (DUF3323)	TIGRFAMs, Coggill P	anon	TIGRFAMs	Family	Proteins in this entry are encoded within a conserved gene four-gene neighbourhood found sporadically in a phylogenetically broad range of bacteria including: Nocardia farcinica, Symbiobacterium thermophilum, and Streptomyces avermitilis (Actinobacteria), Geobacillus kaustophilus (Firmicutes), Azoarcus sp. EbN1 and Ralstonia solanacearum (Beta-proteobacteria).	25.00	25.00	28.50	27.90	23.70	19.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.32	0.70	-5.02	17	132	2009-05-07 16:45:11	2009-05-07 17:45:11	3	5	126	0	50	132	0	205.00	23	50.04	CHANGED	sphsGslpLss.ot.--+puLusLhGRsht..stshplslsch-ss.Lpss...thsshsLtcsL-thhGshlpppppctttppphtphaht.....t.p.hht......psttttWhpplhsttt.........lpphhtss.ctstpllppsspsLttL........s......th..lulhAuplsG..DsHuhDsspssupLlLpAL..............httsptsssss-t..................+pplatpsGllhD-lSsssLshulhshs	...................................................................................................................hsGtlpLp.shst.pE+psluthhG..+sht..tpphplslsph-ps.Lppo....thtshsltplLpthhG...l..p.p.pccpttp.ttppptaht............th.th.ht......pshh..tp.Wlppl.hptth..........ltphh...tps..pt.hp..phlthshpslsp.L...........................Ph.t......p...LslhAspls.u..DsHuhDpsp..supLllpuL..................thhhst.p..s.psucp..........................ppcLahpsGllh.D.-lSshlhshsLhs..t.....................	0	22	39	46
+11630	PF11797	DUF3324		Protein of unknown function C-terminal (DUF3324)	Moxon SJ, Bateman A	anon	Pfam-B_7106 (release 9.0)	Domain	This family consists of several hypothetical bacterial proteins of unknown function.	24.10	24.10	25.10	24.20	23.90	23.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.67	0.71	-4.46	23	905	2009-05-07 16:47:03	2009-05-07 17:47:03	3	3	246	0	66	605	3	142.20	31	41.83	CHANGED	sspslsIpNcYuYsIullLppsssp...lpPcLcLscVpsuphNt.+ssltAsLQNspsshlsplsl-ucVhppsscchLapscccslphAPNSsFsa..slsh.psp.......pLcsGcYpLchsspuscp..................pWcas+cFTIsucpAKclNcp	......................p.ppuhulpNcY..u..YslulhLpps.cpt.......lpPpLpLtcVpssphNu..+sslpsslQNspsshlsplplpuplhccspp.cslhpppppshphAPNSsFsa...slsh.ptp.........................tlcsG.pYplphpsp..sspp....................pWpap+.-FTIsscp.AcclNp....................................................................................................	0	26	53	57
+11631	PF11798	IMS_HHH		IMS family HHH motif	Bateman A	anon	Pfam-B_1349 (release 2.1)	Motif	These proteins are involved in UV protection, eg (Swiss:P07375).	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.25	0.73	-7.56	0.73	-3.60	92	4693	2012-10-03 02:11:09	2009-05-07 17:52:39	3	18	3144	158	842	3371	466	32.10	35	7.97	CHANGED	.psh.tphl..tsl.slpcl.GlGpphtpp.Lpp.hGl	.........tch..phl....tsL.PlpclaGlG+toscK.Lpp.hGI...........	0	246	500	691
+11632	PF11799	IMS_C		impB/mucB/samB family C-terminal domain	Bateman A	anon	Pfam-B_1349 (release 2.1)	Domain	These proteins are involved in UV protection (Swiss).	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.64	0.71	-4.20	106	7945	2009-09-16 12:11:34	2009-05-07 18:00:12	3	45	4183	220	2026	6312	2268	123.60	19	27.86	CHANGED	sp.lp...................pttt+olupppoh.st..sh...pshpplp......th.ltplspclsp+Lp....ppphh...............spslslp................l+........ht..........shp...phsc....phslsh.ssss.spp....lhph...shplh.......tph.hp.....t.....lch.lGlphsplt.....ptsptphsla	...........................................t............pt.pKSlusppo..a.sc.....cl.....pshp.phc.........th.l.p.p.ls.....pclsp+Lc...............ppp..hh......................................scpl..s..lp.................l+.............hs.............................................................................sap........s.ho+................phs..l......t...s....o....ps...sps............lhph........Ahplh.............tch.hp.............sts........lRh..lGlp..l..spl..........t..................................................................................................................	0	644	1225	1687
+11633	PF11800	RP-C_C		Replication protein C C-terminal region	Finn RD, Bateman A	anon	Pfam-B_4463 (release 6.6)	Family	Replication protein C is involved in the early stages of viral DNA replication.	20.80	20.80	21.50	20.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.29	0.70	-4.62	53	475	2009-05-07 17:07:56	2009-05-07 18:07:56	3	4	187	0	99	454	17	181.40	26	51.77	CHANGED	GsWpslpppapslhsplP.Rpsshsp..LcslhsclphLpp-ltshLctttp................spp.suN........-sps-+HhQNSsP-..uh.E.E......Ps..ppppt...........................spss..psppspspPh..............................+sh...PLuhVLcACP-ItsYussG.It...sWRDLhsAAshVRsMLGlSPSAap-AscsMG.csAAlslAsILpR..uspI.sSsGGYLRsLTcRAppGcFSlGPMlMALL..+sputs	..................................................................................................................................Wtthpthattlh.ttls..R..p...sshtp..Lt.lhsphpt.l+...ppl...phLctp.p.......................spphssN..........tspscp.phpsSpsc.....th.-.p..st...ppppt.....................................................................................................h...sl..shlhp.uCPpht.t...as.....s..t...ht........tWp-lh.tsA..hlR.hlGls.psaptAtphhG.ptAuhsluhl.hp+..........htpl..posGGYLR.hst+uttGthpht..hhuhhtt...s..............................................	0	12	45	63
+11634	PF11801	Tom37_C		Tom37 C-terminal domain	Wood V, Coggill P	anon	Pfam-B_30563 (release 22.0)	Domain	The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane [1]. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex [2].	27.00	27.00	27.10	27.20	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.11	0.71	-4.39	17	336	2012-10-03 01:14:49	2009-05-07 18:10:42	3	12	206	0	199	332	0	110.30	24	36.99	CHANGED	Ahhuhlpp+lpslhpYsLYlsscNYpphTR+hauphl.FPh.a.tP.ph+spApcpschlsl............................ptppp.ppc.sptsspls.Shhpchpth......Kppppp.l+p.t.shchhshLpchLsph................phlhuss.....oSs-hLhhualhlhhh.pLPss.hlhsaL+	.........................uhhuhlcpch.shh.ashalsscNY.phT+.hauphhsFPhpahhPsphpptthp+hthhth..............................................................................................................................................................................................................................................................	0	38	77	135
+11635	PF11802	CENP-K		Centromere-associated protein K	Wood V, Coggill P	anon	manual	Family	CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.	22.90	22.90	23.50	23.10	22.60	22.80	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.86	0.70	-5.16	5	82	2009-05-20 17:23:14	2009-05-20 18:23:14	3	3	60	0	52	68	0	210.10	40	81.50	CHANGED	MSt.pp-L.Ps..pDssssh-scEELL+ECEslWK-ME-CQSKLoLlGsETLs-SDAQLSLLlMQhKsLTAElcQWQKRsP...................EIIsLNcDVLL..sLGKEElQKl+pDLEMVLSolQuKNEKLKEDLEREQpWLDEQQQIl-oLsslpcElKNpVsThSESRIFsELpsKhhclKEaKEKLLosLG-FLEEHFP..LP-cptSscKKRKupp.-sSlQLITLH.........EILEILIN+LhslPHDPYVclcDSFWPPYlELLLRsGIALRHPEDPoRIRLEAFHQ	................................................................................................thpt.ll.ppCEp.at.hp..c..hQpcl..h.tsEshs.....pps....t...lhh.phps..LpuEhpphpccpP...................c.hhs.s..tlLh..tlu+cchp+lpppLEhlLSshpuKpccL+csLcREQpWlpEppplhp....ulp.h.pclp...p.ph.pho-.p.phh.p.....-hppK...hhphc......phcccLh.tLuchL-cHaP......L..Pct..sspKK+...+s..hp..csssp...hhslc..................-hlE..hLlN+hhcsP+...D...PYVpIsc.oaWPPYlEhLLRsGIAlRHP-Dss+IRLpsF.................	0	14	20	32
+11636	PF11803	UXS1_N		UDP-glucuronate decarboxylase N-terminal	Coggill P	anon	Pfam-B_36254 (release 23.0)	Family	The N-terminus of the UDP-glucuronate decarboxylases may be involved in localisation to the perinuclear Golgi membrane.	20.50	20.50	20.90	20.70	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.53	0.72	-4.22	5	56	2009-06-11 15:38:14	2009-06-11 16:38:14	3	3	38	0	26	47	0	67.40	63	18.26	CHANGED	Mlppthppll.oGlNRRMMKlLlALALIAYIASVWGsYlNM.RSIQEsGElKIE....QKI-EsVuPLREKIR-LEpSFTQKYP	.............pt...hlh.suhNR..hhKllhulAhhA.YlAoVWG.....NFVNM.....RSIQENGElKIE....SKIEEhVEPLREKIRDLEKSFTQKYP.......	0	2	3	9
+11637	PF11804	DUF3325		Protein of unknown function (DUF3325)	Assefa S, Bateman A	anon	PFAM-B_2004 (release 23.0)	Family	This family of short proteins are functionally uncharacterized. This family is restricted to Alpha-, Beta- and Gamma-proteobacteria.	26.80	26.80	27.70	27.40	25.40	26.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.39	0.72	-4.10	44	248	2009-06-16 09:39:29	2009-06-16 10:39:29	3	2	191	0	82	247	7	104.10	29	92.30	CHANGED	hlsshhL.uauuasuLuLAMp+Hacplh.s+ssss.sptphL..R....hhGWhhLslohhhsltshGh...uhGslhWhGhlohuulllll.hLsYp.......P+...hlhhhu.hsuslhu.........slhhhh	..........lhshsL.sasuassLuLuMs+Hacpl.........h..s+s..ss...tpp..phL..R.....hhGahhLslulhhsltspGh...uhGsVhWhGhLohuAhllsh...hLsap.......PR....hhh.hu.shsslhs.hh...h.................................	0	13	33	62
+11638	PF11805	DUF3326		Protein of unknown function (DUF3326)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2030 (release 23.0)	Family	This protein is functionally uncharacterized. It is about 300-500 amino acids in length.  This family is found in plants and bacteria.	25.00	25.00	56.30	38.10	23.80	23.00	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.93	0.70	-5.72	25	128	2009-06-16 09:50:57	2009-06-16 10:50:57	3	3	111	0	50	129	189	315.40	48	87.33	CHANGED	hs...slL.lVPTGIGCs..................IGGYAGDALPsARLLAussssLITHPN......VlNGAsLYWsssslhYVEGYuLDRFApG-huL+PV+ppRlGLlLDAuIEsEL+pRHLQlA-AsRATLGLslsshlhTDtPLtVpLptus.SGuSWGsl-pPDuLLRAucpLh.csGAsAIAVVuRFPDD.sotthptYRpGpG.VDslAGAEAVISHLlVRcLplPCAHAPALuPlsl.....sspLDPRuAAEElGaTFLsCVLlGLSRAPclls........sstspssslpus.plsAVVsPtGAlGGpuVLAsh-+...sl.P.lIuVtpNsolLpVoscsLGls..........lltlssYhEAAGlllAlRcGls.suLpR	...............hsslLIVPTGlGAt..................IGGaAGDALPlA+hluulsDpLITHPN......VlNGApLYWs.sNshYVEGYuLDRFAtGphuLpPV+p..N+lGLlLDpuIEs-Lt.RHlQsA-AsRAoLGLslschlhTDsPLplphphus.SGtShGoltsPDuLLRAscpLhppssApAIAlVuRFPDDsssthhptYRpGpG.VDslAGsEAlISHLlV+pFplPsAHAPALtPhsl.....ssplsPRuAAEElGaTFLsCVLsGLSRAPphlp...............tt.s....stsss.lhss.pVsulVlPtsAsGGpulLuhhpp...ph..s..lIsVp-NposhpssscpLslp..........shtVssYhEAhGllsAh+sGls.sulp........................	0	10	35	46
+11639	PF11806	DUF3327		Domain of unknown function (DUF3327)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2060 (release 23.0)	Family	\N	27.10	27.10	27.40	28.10	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.89	0.71	-3.81	35	840	2009-06-16 13:03:42	2009-06-16 14:03:42	3	6	641	13	81	482	3	128.80	46	31.19	CHANGED	pt..................hVTF............lWR......uss..............sshtlasshsultpp..........tpphpRLsuT.........DlW...................................ahohplPusaRuS................Yshhsssss.................hcsstcpthRtlhsp......upsDPLN.pshhsst........hhpttSsLcLssAsspsths	............................................................tsp.h..cVTF............hWR....s-ptS..............sl++ValhlsGVTD++psu......spsMpR.lsGT.........DVW...................................phThpLsAsaRGS................YsFlPstp-s.......................PDct.t..LRcGWRplLsp......AhADPLNspsatsGR..........GpssSsLchPpAPhQstW.s.................................................	0	13	32	60
+11640	PF11807	DUF3328		Domain of unknown function (DUF3328)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2062 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in eukaryotes.	25.00	25.00	25.20	25.00	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.96	0.70	-4.66	101	775	2009-06-16 13:12:53	2009-06-16 14:12:53	3	5	79	0	677	817	0	184.60	18	76.48	CHANGED	ptptpppttahhh.............hhhhhhhhhhshhhhhhthhhht..t.h.t.........................................h.h.........................s.....aps.sss...-h.-puW.............tshhlstpt....h.phshs.........h....st.............shhhtlp.saH....pLHCL.....................phlRptha.ph....................thtpss.pt.....................htHhpHCl-hLRQslhCpuDsslh....s..h............................stshss...............................hss...p+pC+sa..-tlhc..............Wspcp	................................................................................................................t......................................h...h....h.......................................................................h.....h...................................p.......a.....t...ss................ph.-ts...W.............................t....hh.h.stpt...............h.ths........................ss...................thhhtlp.saH.....pLHCL...........................phlRptha.th.............................t.t..t..tt.t....................................hhHh..pHCl-hLRQ......slhCpuDssl.......sh.hht...........tt.hss..................................hss.....HpC+.s..aptlhp..ahtt.........................................................	0	107	349	527
+11641	PF11808	DUF3329		Domain of unknown function (DUF3329)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2082 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.	27.10	27.10	27.30	27.60	26.90	27.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.06	0.72	-3.90	33	1029	2009-06-16 13:53:43	2009-06-16 14:53:43	3	10	1017	\N	175	598	65	89.50	47	20.74	CHANGED	hphsap.phltcLslhhlsslllGhlhGplshhLhlushshLsWHhhplhRLppWLapc+phs.PPpupGsWptlFsGlYRLQpRsR++Rpc	.......................E.RLoWK.+LlhELlLhslP..A..hl...lG....hhh...G....a.l...P...W..h..L..L...A..u..l..s..ul..L...l...W...Haa...sLl...RLShW..LWs-R..shT..PPsG..pGuWEsLhaGLaphQhRN++RR+E...................	0	29	76	127
+11642	PF11809	DUF3330		Domain of unknown function (DUF3330)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2077 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.	25.00	25.00	26.70	26.60	23.70	22.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.79	0.72	-4.11	9	204	2009-06-16 14:09:36	2009-06-16 15:09:36	3	2	158	0	20	76	4	67.30	73	44.19	CHANGED	sssMNssssosTSCCVCCKEIPLDAAFTPEGAEYVcHFCGLECYQRFpARA...pssscssstPs.ss.....sspP...os	................s.ssMNAN-PS.TSCCVC.CKEIPLDAAFTPEGAEYVEHFCGLECYQRFQ.ARA...pTATETslcPs.ACDS.PSs.........	0	6	10	15
+11643	PF11810	DUF3332		Domain of unknown function (DUF3332)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2104 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.	25.00	25.00	43.10	43.00	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.03	0.71	-4.61	25	244	2009-06-16 14:14:27	2009-06-16 15:14:27	3	1	223	0	47	189	10	171.90	36	95.19	CHANGED	+pphhtssshshssstLoGClGphuloshlh.chNl.....puVDNRYuRuGla..hlluPVYGlsssADhllFNSIEFWoGpNPl.......stc.PulsDs.s.cshh....clNsp.lctsLscsPlshh......pphcpuphphlDspshphplshssGpptpLhGh+.psspVshYl.DGchlsh............sohspLtshtpss	.........hhhhshhhhhuss..houChGphuloshlt.caNh......psVDN+as+EhlF...hlluPVYGlss.hADhhlhNSIEFWTGpNPl.......stt.ssVsDh.h..cslh....clNsp.lshphpcsshphp........+.hEpush..c.lpscshph.lshssGppph.Lhshp.ssspVshaL.sGchhss....lstptltuhhpss................................................................	0	10	21	37
+11644	PF11811	DUF3331		Domain of unknown function (DUF3331)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2106 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family vary in length from 96 to 160 amino acids.	25.00	25.00	37.00	37.00	20.20	16.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.37	0.72	-4.41	24	164	2009-06-16 14:22:22	2009-06-16 15:22:22	3	2	48	0	66	160	2	97.10	39	75.80	CHANGED	ttpsts.hsutssss...........thtlpllER.osoolhVpWsDss+C+YuEQpW+hshARpsGhCALSGpsIchGDsVa+Pph.R..shPsNusAMILAuslsphhst	..........................htss.........sshp........tsplpllER.SsoslsVpWs-ss+C+YGEQcWRtthAcpsGpCALSGpsIptGDsVa+Ptt.R..ssPuNusAMIhAusltt...st....	0	1	7	30
+11645	PF11812	DUF3333		Domain of unknown function (DUF3333)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2108 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.  This presumed domain is typically between 116 to 159 amino acids in length.	26.50	26.50	26.50	26.50	26.20	26.10	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.59	0.71	-4.23	62	456	2009-06-17 11:52:16	2009-06-17 12:52:16	3	4	432	0	116	348	598	144.50	29	36.69	CHANGED	hctpl++R.tAE+RF+haGluAIslulhhLslLLsoIlupGhsAFppThlplslplstpt.l-.ps.t.......ptltstsYtsllpsAltp....hshp.tst.st+thtt.llSpsAttpLR-hlhssPpllGpThshhlhAsucl...DshhKGps.s..tpshtps	............ctthK+R.tA-+pF+hhuhhAlhluLhFLsllLsSlhspGasAFpQThlhl.lphspts.ht.........................shlttu..sh.hlhpsultc....hsss..s.sp...t.p.chsp.hlS.pptthtlcchlhts.sthlu.pspshhl.usuch...D.hhKut..........s..........................	0	37	80	95
+11646	PF11813	DUF3334		Protein of unknown function (DUF3334)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2118 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family are typically between 227 to 238 amino acids in length.	25.10	25.10	25.70	45.10	22.00	25.00	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.52	0.70	-4.81	19	187	2012-10-01 19:50:22	2009-06-17 13:02:51	3	1	184	0	41	122	9	223.30	68	99.13	CHANGED	hppsplloT-DILLpLCpSVopVLosATpSpVpYSuMVQ+Is+TsLKPDlGCFVLFDGGFSGLVVINFSApAAhElYppYMLsMGMPcpELAhSHTSDEVuNVMGELMNQlVGDFTuKlp+ELQTsITQNQPKMLslNKQlhLSVDTNLDcPpARRVoFpTtpNpIFYLEhAMDKTEFIpLp-FEhcEc..DPDsLltppt......ttttspssssts..ttc............................s-sDDLLcpLGl	.........MpKsplVTTEDILLhLCpSVSsVLoSATsS.lpYSAMVQKIsKTSLKPDhGCFVLFDGGFoGLVVINFTAcAAlElYssYMRNMGMPE-ELAl.HTSDEVGDVLGELMNQlVGDFTNKVRKELQTsITQNQPKMLoLNKQVhLSVDTNLDRPQARRVTFoTsNNNIFYLELAMDKTEFIQL-EF-hp.E-p.sPD-ILttsp......ppp.p.spssssps..tpc............................ssusDLLDpLGI.............................	0	6	15	29
+11647	PF11814	DUF3335		Peptidase_C39 like family	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2152 (release 23.0)	Domain	\N	25.00	25.00	25.20	29.10	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.17	0.70	-5.19	25	210	2012-10-10 12:56:15	2009-06-17 13:04:35	3	5	202	0	49	172	23	201.10	47	55.40	CHANGED	lPaYpQTT-FTCGPAsLhMAMusLcspht.spppELplWREATTIFMTSGHGGCuPaGLALAAh+RGacsclalsssusLFlDuVRsppKKpVhpLVccsFtpplpppsVslphpshohpclcptlspGttslVLISoYRhsGcKsPHWVllouhD-calYlHDPcl-.tpppcsshDstalPIu+p-Fs+MupFG+s+.LRAAVllppp	...hPaYhQTTsFTCGsACLLMAhus..L......c....t..shp.oRspElpLWREATTIFMsuGHGGCuPpGLALAAtR......R..Gac..V-lhsssp.u....s.FlD...uVRsssKK.......pllcLVHpcFsppLsppsVshh.tssstspLcphlpp.GupsLlLI..SoYRhsu..c.K..tPHWVllouh....s-.cFhalHDPc............s-................pc.....cpsh-stalPVu+ushsphhsFG+p+.hpAsVllt.p.............	0	15	30	42
+11648	PF11815	DUF3336		Domain of unknown function (DUF3336)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2157 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in bacteria and eukaryotes. This presumed domain is typically between 143 to 227 amino acids in length.	25.00	25.00	27.90	27.00	24.80	24.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.68	0.71	-4.68	82	500	2009-06-17 12:07:04	2009-06-17 13:07:04	3	5	249	0	353	491	21	145.30	26	20.75	CHANGED	thhcpp...hhp...........pLhcphcs........................upoYc-WhpsAtpLDch.....hGtstW+.psspss..hYDaphlppplppLcpsRtps-h.........................................ppLhhllcsslpRNhuuh...ssspLYp+oah..GTKpLI--YlcElttslphlscs....pplssp...phhthhppspps	..................................h.............php....pLpp.phcs............................Apo..Yc-WtpsAtpLDch.....hGt.stW........+.....psspos.......hYDhpllppplppLcctR...p.ps...-h............................................pplh...h...ll+s.s....lhRNhu..sl......sss.pL.Ypcoah....G.T......KpLI-cYlsE..lt..psLchlspt............pphs.p...thhthhppht................................	0	100	200	307
+11649	PF11816	DUF3337		Domain of unknown function (DUF3337)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2058 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.	25.00	25.00	26.00	25.30	21.20	24.60	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.13	0.70	-5.04	30	297	2009-06-17 12:16:39	2009-06-17 13:16:39	3	23	247	0	215	309	1	296.90	26	35.92	CHANGED	ptshssppphhspp...........sssssshhshsps..tthpssupss.ptt.t...........stsPst.shs..tppsphssohhs.cchch....s.h.tc.ttt.pt......................ptstppspppp.hc.shuuhltpshppa..pphtssst........................sphpPs.ttcss.hh......plPscoslllpE..sstusspslaRt..plsshspct..........-hlp...cslPhWluchLLcNphP.K.-s.sKlsFhLpPa..............c.....................sthPshscs-.................................sssRLsAscMLRs+KIhsYVsE+l......sps.....pp.pspt...............................................................hcPc-aLELhCps..................pl..Lss...sMTLuTlRshlWKouuDllLpY+tpsc	.......................................................................................................................................................tpp...........stttsthhsh.ps......hhhps.up.ss.ppp.pp.....................s.hPshhsh-....cpuhhshsh....cc.ph......h.s.h..........................................................ttst.sstptp..s..c.Nhsshl.phhhca....pht.ps.p................................................................................tsphp...s.ss.....pp......tss...hh..................plP.....scosllhtE..........uust.slaRh..hlpshss-t.......................-...h.........cshP.Wlh-hl..l..psp.h........P...c.....sKlsFhLpPa................................s.............sshsphh.pts................................................RLsAs....cMLpl+K.lhtaVhE...+l.....st.ps............................tp.ptst..........................................................................................................hhs--hlELhCps....................pl..Lss...sMsLtTl+palWKs..us..DlhLpY+tp..p..............................................................	0	69	121	179
+11650	PF11817	Foie-gras_1		Foie gras liver health family 1	Coggill P	anon	Pfam-B_4417 (release 23.0)	Domain	Mutating the gene foie gras in zebrafish has been shown to affect development; the mutants develop large, lipid-filled hepatocytes in the liver, resembling those in individuals with fatty liver disease [1]. Foie-gras protein is long and has several well-defined domains though none of them has a known function. We have annotated this one as the first [1]. The C-terminus of this region contains TPR repeats.	23.30	23.30	23.30	23.30	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.44	0.70	-4.90	22	379	2012-10-11 20:01:02	2009-06-17 18:05:52	3	16	226	0	279	399	0	215.80	20	20.99	CHANGED	+h.-s+hluDhlsh+I................hRhhLhsupss..sAlppaptHhp+hp-h......lsp.h.ut......t..tatuW.uR....htlhA-Llcpsshsthsshp...................................sGaahppAAc.ahhtR+phtpph.............P........pssuuplhsphahhcsh............sspsppthshsts..pthsHSt.IlshLppAhtpFpphpp...........sRhsptLsh...chAcEYh+hs.sascAhphlcsl..shsaRp-sWhsLhpchhhtL+cCAhphtDscshlpsshELhsh	......................................................................................................................................................................................................................................................ph+.hhthhth+h.................h.chhh.....tps....tAhtphptHhphhtph.........................hs.....p............t..th.sW.up....h.hhuplhpps..................................................................................................suhhh..uA..hh....+pthht.h........................................................................................................................t.h..............................................t...th..............t......h..psthhlphhp....pAhtpapphtp.........................Rhtphlhh.....phucpa.ht.ht..pap...pAhphhp.h....hhpa+.........pEtWh.tlhpphhhthhcCthhhsphtshlphshchhs.t.............................................	0	81	141	219
+11651	PF11818	DUF3340		C-terminal domain of tail specific protease (DUF3340)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2330 (release 23.0)	Family	This presumed domain is found at the C-terminus of tail specific proteases. Its function is unknown. This family is found in bacteria and eukaryotes.  This presumed domain is typically between 88 to 187 amino acids in length.	28.60	28.60	29.40	29.20	28.30	27.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.63	0.71	-4.23	98	1144	2009-06-18 09:33:45	2009-06-18 10:33:45	3	5	1125	0	222	767	468	142.30	45	20.88	CHANGED	ohl-st-hGEss.-NALPWDpIssApYsphsshssh...lspLpppHppRlspss-Fthlpcclphhcpp+-c.pslSLN.spRctEpcpt-pp..pLpth.......NpRhp......t.tG..p....cslpsh.........................-.........................................-h..sc-h.........tt.Ds....aLcEuspIhhDhh.......phpp	.....p....tsEsGEphEDNALPWDoIc.u.As..Y.s+s...sc..ls...sh....hscLhccHpsRIAcDPEFphIhcDIAcapsh..KD+...shVSLNhutRccEssccDup..RLsRl..................N-Rh.K.........p..cG......K...s.LKcL........................D..............................................................................Dl....PKDY...............pcPDs......YLDEolpIslDhscl..p............................	0	60	117	178
+11652	PF11819	DUF3338		Domain of unknown function (DUF3338)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2474 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in eukaryotes. This presumed domain is about 130 amino acids in length.	34.60	34.60	35.40	35.30	34.10	34.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.59	0.71	-4.72	8	236	2009-09-11 14:35:59	2009-06-18 10:36:45	3	8	64	0	127	216	0	132.30	48	17.22	CHANGED	hEuKsclIsuSSGolluSGStsu-sS.csKKE+lpsLKcKpcsLc-+Lpt+LcELKKlCLREA........................ELTG+LPsEYPLpPGE+PPpVRRRIGTA......FKLD-..lLs.sE-stLpsLEschAlQQQIsEAA++LusEscLSKsl	.................................tuKsplI.sSs.GolluSG.u...pu-s.ut.psK...+.-hltsL+p+pcsLpEpLpp+lEELK+lCLREA........................ELTGcLPtEY.....P..LcP.G...Ec.....PPpVRR.RlGTA.................FKLD-...pl...L.....s.t..tE-...stLp...pLEpchulQppIsEAA++LAs-PsluKp......................................	0	17	30	65
+11653	PF11820	DUF3339		Protein of unknown function (DUF3339)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2694 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in eukaryotes. Proteins in this family are about 70 amino acids in length.	25.00	25.00	36.80	25.60	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.39	0.72	-3.68	25	199	2009-06-18 09:40:15	2009-06-18 10:40:15	3	5	29	0	126	175	1	66.80	52	81.93	CHANGED	MsDWGPVlluVlLFVlLSPGLLFQLPG.+sRhVEFGshpTSGhSIlV.Hslla...FullsIhllAlplH....lYs	.......MuDWGPVllulVLFlLLSPGLLhQlP.G..+.sRhV.EFGshpTSGhuIlV.Hulla...FuLlsIhllAlslHlY..................	0	16	74	100
+11654	PF11821	DUF3341		Protein of unknown function (DUF3341)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2731 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in bacteria. Proteins in this family are about 170 amino acids in length.	25.00	25.00	25.20	26.50	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.02	0.71	-4.79	37	213	2009-09-11 12:21:10	2009-06-18 10:43:59	3	3	197	0	114	226	320	170.60	31	77.66	CHANGED	tptslhA.Fscs-sLlpAs+plRt...tGa..phh-saoPaPlHGLDcAhGl.t.oplshhshhhGlsGsssuhhhphahshhD..........aPhsI.GGKPhh..Sh....PAFlPlsFElTVLhAAhuhlhuhh.hhstLs.hp+Phh.ss...+socD+Fhltlsssss...-tpchpphLcphGAhclphlp	......h..hslhA.Fsss..-sLlpAs+pl+p...tGa..chh-...saoPaPlHG..L-cA.hG....l..tco+....lsh..hshhhG.lhGhssuhhhthashhhD.................aPhsl.GGKPha..Sa....PuFlPlhFElTlLhA.Ahshllshh.hhspLs.h.t+shh.ss.....R.s.ocD+Fhltlpspss....stpphpphLcphGAhclp...t.................................................................................................................	0	54	88	104
+11655	PF11822	DUF3342		Domain of unknown function (DUF3342)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2751 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is found in bacteria. This presumed domain is typically between 170 to 303 amino acids in length. The N-terminal half of this family is a BTB-like domain.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.32	0.70	-5.29	9	124	2012-10-02 01:20:04	2009-06-18 10:46:24	3	4	99	0	82	233	4	273.00	41	42.62	CHANGED	s.IpVpDcspNppRsFpCspcLLhocMpYFssllph.................................................................sspch............lsIpV+CDlpIFsWLMpalct.................ctPplsPsNVVSIhlSSsFLpMppLl-psLtYh+t+LsplVtousNhsClsspLlsRLusMhscs-Lst....l+Dc+schps..+lhspLIp+.LC-..sps..............................ts..uph.....suLhhCthCtpLhsppp.p+lpp.........sPu....................+hslspRGclhhoHsts+..................shsspta..lsshpcELcuWt...WRlhGuhpalhCpRCpphhslh-ho..pCphtPtshsassssup.Dstu.suhashC.tppshca-	................................................hlIHVCDEsK.shpcDFhCPpcLLlscMpYFA-hl...................................................................s.u.Q+h-E..........lDIS.VH.C.D.lpI...FsWLhpal++s...............................................................tttchPp.L..-ssNVlSILlSSpFLpM-.sLl-pClpYC..Hpp.hs.....tIVt..ossNhsClsssLloR...........lAshFoptEl-t....l+DKK.DKhpS..+LasKhIpp.Lh-sp..s...................................cu..ssh.....usLa..RCshC..tpllspphpp..plsC..........hPu....................phplsp+Gplh..hHh.RD.p.............................................................sWslppY..l..sLacEL+SWRc.....VYWRLWGshpaL.hCspCtphF.sh-hs..aCpaHscss.a.ssssp........s.sGhYsCC.sppshRa-.............................................................................................................................................................	0	32	41	62
+11656	PF11823	DUF3343		Protein of unknown function (DUF3343)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2956 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 78 to 102 amino acids in length.	25.00	25.00	25.10	25.00	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.04	0.72	-4.72	58	857	2009-06-18 09:51:36	2009-06-18 10:51:36	3	6	709	0	160	521	6	70.90	27	76.57	CHANGED	ptphlllFpospcuhpsE+.....lLKcpsl.shcllPsP+pl.psu..C.Glulchst.pp.tptltphlpctslthpt....laphp	.....................calhhFpoTstslpsc+.........................hLps..t..uh.sh+lh..slPR.cl..puG...C.Glslhhs.....s.ss.t-clphll.ttt..hpsla.....................................	0	90	133	147
+11657	PF11824	DUF3344		Protein of unknown function (DUF3344)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3041 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 367 to 1857 amino acids in length.	27.20	27.20	27.50	27.50	26.20	25.90	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.88	0.70	-5.02	42	118	2009-09-11 16:28:30	2009-06-18 10:53:44	3	42	17	0	94	122	4	276.20	22	40.86	CHANGED	ssshsss..a.Gst.....s....Lsohtp..ssV.....pGslhhss..........hhGhssps..............spsh....slP.su........slchA+LYls.sWst.........ppsh.sphslsFNG..........ppht.........................ssts.Ysshps......assh.p....shas.YDVTs...hlss....G..psssslss...........sshcG.....plhussLlllYc.ssstsphp.YWlN-GsDhlph...............sscpssups.Fsus.ss.s..lpsAsLhohhhoustt......sslhFNu............sslhsus............................pushhshp.tasVsshlpsspNpshh.s............tsssYhpsshulLslch	......................................................s.....tt..a.us......s....lsohtp..ssl.....pGslhhss............h.uhssps...............spsh.....slP...ss......s.....slphA..+LYls.sWst.........pssh.sshslsFNG...........................pth.................................sssstYhshss...........ass.hhs.sh.shhh.YDVTshlps.....u.pssh.slss............tsshcu......plhshsLllsYp.ss.sssphp.halN-GpDhlsht.t...............tscpssups.sFsss.hs.t..tlpsApLhshhhuu.s..s.........ushhFNu....................pslhssss.................................pus.hshp.taDV..ssh...lps..ss..spshhts................tsushhpsh.uhLslp...................................................	0	50	62	72
+11658	PF11825	Nuc_recep-AF1	DUF3345;	Nuclear/hormone receptor activator site AF-1	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3322 (release 23.0)	Family	Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [1]. One of these activation domains is at the N-terminal, although there are two distinct motifs within this domain, between residues 20-36 and between 74 and the end of this domain, which are the binding regions. One of the co-activators is TIF1beta, which appears to bind at the first motif [2].	27.30	27.30	27.30	27.30	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.83	0.72	-4.15	14	198	2010-01-08 15:29:35	2009-06-18 10:54:52	3	5	47	0	73	155	0	100.60	44	24.06	CHANGED	uoSlssssths.hss........Hssh......sshss.t.h....osluSP.lNulGSPaSVIo.SolGssShulPuT.PulGassh.SPQhN...shs...uVSSSEDIKPP.GLpsl......phsspusGuh	.........................................ss.ts......s.HPSh......sshss.t.l.....SsluSP.lNulGSPasVIo.SuhGs.uh...slPuo.PuluaushsSPQl...NS.....shN.........uVSSSEDIKPP.h.GLpGl.....hphsupssGsh.............	0	2	10	30
+11659	PF11826	DUF3346		Protein of unknown function (DUF3346)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3462 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 231 to 659 amino acids in length.	25.00	25.00	37.30	36.50	20.00	16.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.47	0.70	-4.57	4	170	2009-06-18 09:56:55	2009-06-18 10:56:55	3	2	126	0	11	121	0	220.10	88	43.69	CHANGED	FTDFQLHELTGRWLSEN.MPEGFKSDRFRFLARTITASEEAPpEGpDGEIRIKPNLYILVWEPSFa-ELLTRDYFF.LFPPEILKQHTLVFQLYSFFRSRMuRRhTDsMLLSELNQKLARNI-WRRFShDLIRELK+LuEGKsoE-lFlVNLWGYHLTIpuh-pstKlsDYQIDI+CDs-E.VlRYSRA+TTNsGKRsM.APThPNPLRNElhsKQcL-pLSuIIDGEF	.............................................FTDFQLHELTGRWLSEN.MPE...G.FKSDRFRFLARTITASEEAPsEG.SDGEIRIKPNLYILVWEPSFaEELLTRDYFF.LFPPEILKQHTLVFQLYSaFRSRMuRRHTDsMLLSELNQKLARNIEWRRFSMDLIREL+R........LS-G.KGoEDLFVVNLWGYHLTIcoh.EcGKVhDYQVDIKCDVEE.VLRYSRA+TTNAGKRNM.APTLPNPLRNEhVoKQpLsELSuIIDGEF............................................	0	1	3	8
+11660	PF11827	DUF3347		Protein of unknown function (DUF3347)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3580 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 169 to 570 amino acids in length.	25.00	25.00	38.70	38.70	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.35	0.71	-4.27	46	213	2009-06-18 09:58:49	2009-06-18 10:58:49	3	7	83	0	98	245	40	172.30	25	54.87	CHANGED	hshh...hhhsusppppcpp.h.....................pthtttt....................tphthsphtspphpplhssYhplKsALVss-sppApssAppLtpshpshshp.......phhspttpphtphh...............slcpQRctFptLSpphhshlcts...hsssslYhpaCPMA.sscGA.WLSpsccI+NPYaGcpMLsCGpVpc	....................................................s............tt.t........................................................................................tt.thstttppphptlhssYhplKsALspsDsptApssApplhpslpt.lshs................thts.ptt..pphhphhpp.h.tt................tclcpQRp.tFptLSpshhsllcth.....tsspslYhpaCPMsp.sspGu.WLSp..sc..c...l+NPY.......aGspMLsCGplp.........	0	47	84	95
+11661	PF11828	DUF3348		Protein of unknown function (DUF3348)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3615 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 244 to 323 amino acids in length.	25.00	25.00	25.10	98.20	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.52	0.70	-4.95	19	133	2009-06-18 10:49:21	2009-06-18 11:49:21	3	1	131	0	44	153	14	243.60	46	94.84	CHANGED	MsQsPpRsshuGPsLlRLLARLsss-sspSppuLu-RLSQWLsWoDAlALSuA......LsupsPssssuspssusstc.....-tARlRusLspuIsscts.ts.tRtts....h.hsshssssp.stsDaAsaRQpYLuhQpsMcssIusLRGRLRstLAuposs.hARLAhlDAlMEpsLusRERsLLAslPsLLts+FERLRpsccts..ststss...........................hstsGuWLssFRpDMQSVLLAEL-lRhQPV-GLLAALRsp	..........................Mhpss.RssLuGPsLlRLLARLscs..Dls....tStpuLuDRLSQWLuWTDAIALSuA......LsussP.us..s..s.....u...s..cst.utstc....tpsARVRsuLApAIssssshhs..sRtts.........pssshss.s..ss...sss....DaAsFRQ+YLuhQQsM-sslGpLRGRLRptLAsposs.hARLAslDAlMEpsLusRERoLLusVPsLLus+FERLRcAcptsh.t.ts.t.st.sts............................................................sssPsuWLDsFRcDMQSVLLAEL-lRFQPV-GLLAALRsp.	0	6	19	32
+11662	PF11829	DUF3349		Protein of unknown function (DUF3349)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3716 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length.	25.00	25.00	28.80	28.80	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.25	0.72	-3.56	24	263	2009-06-18 10:51:17	2009-06-18 11:51:17	3	2	128	6	68	170	2	97.70	43	87.82	CHANGED	hsshlsslluWLRAGYPpGVPssDhhsLLALLpR+.Lo--EVptVAppLhc..pup.s.......spsDIsshIsplTcc.PsP-DlcRVpA+LAutG.....WPLssscp	.........spalpSllsWLRAGYPEG.VPssDphsLLALLpRp.Lo---lppVs..pcLhc....pGs.s...................Dp.-IushIoclTcc.PuPEDlpRVtu+LAAtG.....WPLsss.c..............................	0	14	42	58
+11663	PF11830	DUF3350		Domain of unknown function (DUF3350)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3789 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 50 to 64 amino acids in length.	25.00	25.00	29.50	30.70	22.00	18.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.84	0.72	-3.94	11	178	2009-06-18 10:57:16	2009-06-18 11:57:16	3	7	70	0	79	164	0	57.80	56	5.47	CHANGED	-lsPpusLSPshttt..........tssttct+RoscELRcLW+pAI+QQILLLRMEKENtKLp	.............................EL.PhSPLpPshE-t..............ss.t..pcc+RsScELRpLW+KAIcQQILLLRMEKENQKLp.	0	13	18	42
+11664	PF11831	Myb_Cef	DUF3351;	pre-mRNA splicing factor component	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3985 (release 23.0)	Family	This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.	27.00	27.00	27.60	27.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.63	0.70	-5.14	29	298	2009-06-18 10:58:48	2009-06-18 11:58:48	3	12	252	0	217	288	1	227.90	29	30.07	CHANGED	TPNPlhos.hppst...............thGhTPhpsh..........GtTPh..pTP...RDphslN...........tt.....htpospph+hp.pppt+ppL+suLuuLPpP.cN-aEl.lP-pt......pp-.scptEp.....h...EEDuu-t-tRc+ttcptpcptchc+RopVlQRsLPRPs.lsht.Lh..............phssp..s.sccllpcEhhtLlppDsh+aPh...sssp..ttp............................t.th-phs-stlppA+thlptEht..h.................t..sppppphc............sasps	.................................................................................TPNshh..os.hRp.s...................t.uhTPtts............utTPh.....pTP..........hRDphsIN............ppt...........stss......P.p....+.t..ppph+pp....L+tuLuuLPtP.cN-aElslP-pp...............ppE...pptct..................h....EDsu-h-tRppttc-tpcttEh++popslQ+sLPRPst.ls.phLh...................................................p.s...st..hppu-cLIpcEhhphltaDsh+.a.Ph...sssp...ttp.................................h..h-phscppLp..pApphltpEht.h............................t.t......................................................	0	74	117	174
+11665	PF11832	DUF3352		Protein of unknown function (DUF3352)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2160 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 538 to 575 amino acids in length.	26.80	26.80	27.40	26.80	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	536	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.62	0.70	-6.20	32	156	2009-06-18 11:54:13	2009-06-18 12:54:13	3	5	102	0	59	174	55	465.90	18	84.34	CHANGED	slhuushlLlshusuhaahhtpp.psl.hhpps.hshPhuAphlPpsA.lslplhssPscl.shtphsss.pp+pthppthpp........h+cshhAtsGlcapp-.lpsWlGsplolAllss....s.sp..................tpsuhlhsLssc-sptA+pFLpph.appcshsG.sslphpsY+Glplhpspsshht.............shusAll..s-p.hlLlAss.tllcpAlDshQhss.shtus.thppslppL..scs.lAhlhh.s.ssht.......pa........hpl.spslsphp.slpullsulshpspuLthcuhhhhpsph.....sss.sps.....Lpphsusshhhlu..........sLpp.appls........psss.hsphlp.lhpphhpthshslspslhsh...pGchhh.hlsts..........suWlhsspppsssss............p..LDphhp.spG.hphsslshsspslssWop.........................................L.h..t.t.........ltsp........lsss...........+uthsspthaussLsulspthss.....tpsLtss.phppslssh.....tsstt.hhLshptstshLsp.hhPh........hhh.hthsupslhsslpululss...........................tss...ssshhphchhLplt	.......................................................................................h...hsshhlhshuhushhhh.tt........ts..p....sshhlPppA.hhhph.sss..pphtth.....tphhs.......ppppt.......hppthpp........hppph...hst.ss....lsapp-..lpsWlGp.clslA..lhs.shpt..........................tpsshLlslshp..ctptucphl.pphhppps.ts.hplp.pppYpGlsl..hthpsstst......................h.ssAll......scp..allhuss.pl.lcpAI-shpsss.slsps..sappshppl......sps.luhlah.shssl....................................phh................hsh.sp.hs.ph.p...thp......shs.....hulshptpulthcshh....hhpss.......................s...st.......hlph..hsspsh.hh..hs........................................slsp.a.pt.htp.h......ttss.h..phhpphhtphpp.hslsltpslhsW..hpGEauh.hl.pt.t............................tsshlhhsptp..stt.............t..lcthht..ptt..h.htph.h.tt..l..Wp....................................................................tt.....................h.hh...........hs..st..hhht.htshtth..........sl.tp.th.p.h.............t.hhlshp.....h..t.....s...................t.hh.thpulshs...............................ttt..t.phhh...........................................................	0	17	45	57
+11666	PF11833	DUF3353		Protein of unknown function (DUF3353)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2231 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 205 to 258 amino acids in length.	28.40	28.40	29.30	28.60	27.70	26.70	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.22	0.71	-4.85	34	209	2009-06-18 11:57:17	2009-06-18 12:57:17	3	4	100	0	110	207	132	176.70	25	71.90	CHANGED	sp-ASFEElQpARsphLpph.usDtpspsplEAAYDulLMppL+pRQpG+ltlsptlphscp...........tsssstsstsssshlpch................s.lshPpspslhhphsh.GsLullhllh.........s..ssssspLhLuluhhuslhhhh++...tp+hhpuhhholssLhlGlllGullsshl.s.hls..hshospplpulsshllLaluuhhL	.............................................psASa-EIp..tA..+shllpph..sscppshtp.........lEuAYDtllMppLpp.RppG....Kl....plspcl+hsc......................stssssWlpph......................hp..h.Pstp.sl.hhphhhauhlsshslh............s...stssssh...lA..luhh...uslY.Flp.c.+............tp.phh+uhhhshssL.hhGhhhGshl..shl.s.........hs.p.h.uhhshhhhalss.aL................................................................................	0	26	73	98
+11667	PF11834	DUF3354		Domain of unknown function (DUF3354)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2265 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 60 amino acids in length.	29.60	29.60	29.70	29.90	29.20	29.10	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.41	0.72	-4.36	43	290	2009-06-18 12:00:32	2009-06-18 13:00:32	3	39	100	0	145	279	0	67.50	36	10.74	CHANGED	hhRVoIa...sspc....spts.GKLlhLPsSlcELlcIuupKFGh.s.s.ocVhsp-.GAEIDDlclIRDGD+Lall	......................tRVola..tsspp.......t.....GKl.lhlP..s.olp-LlplAupKhGh..t..s....opl.hstc.GucIDDIslIRDsD+Lal......	0	25	77	113
+11668	PF11835	DUF3355		Domain of unknown function (DUF3355)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2268 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 111 to 177 amino acids in length.	26.70	26.70	49.10	49.10	23.00	22.60	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.13	0.71	-4.43	5	57	2009-06-18 12:04:15	2009-06-18 13:04:15	3	2	3	0	21	51	0	152.20	44	28.56	CHANGED	TPTKCSTPVPSsAITKuVAESTPTslEHVFPATsusSsPSIuSAAtsTPVSLTtTKEAEADMsKVE-Ko-cTlpDLCsK....INpMLEsp.....E.hhusDSTtsVslhussTsssshsLEhsp-..App..h.phsppp.hs.hps.............ssc..hspc-hltthclsoK	...............hPTKCSs.sPSsATT+ssAcSosss.E+VFPAThus.sPSssSushsTsss.sETccs-usMDKs..ps-cThQDLCs+...............IsphLEshRshK.-.ohShD.stslsshSsNsssss.........hhhEVSsE..AsshphVsoschshssshps...tp..p....ssst....sMsp--hhchhcVsoK.........................	0	0	0	5
+11669	PF11836	DUF3356		Protein of unknown function (DUF3356)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2406 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 104 to 119 amino acids in length.	26.90	26.90	29.00	28.20	26.30	25.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.07	0.72	-4.21	42	205	2009-06-18 12:07:32	2009-06-18 13:07:32	3	2	175	0	72	166	41	99.10	39	86.19	CHANGED	apGEV...........slslsGpppsh+LTLGALAELEsthus.....ssL.......suLspR...Fcsup.hSu+DlltllsAGLRGGGhsssps.-lhpspltGGsh..ss.ucsAApLLspuF..shs	................hRGElshplsGccasLp.L.TLGALAELEsshts.....ssL.......sALltR...FssG+.hSuRDlhplIsAGLRGGGpsss-c..-lushps...cG.G.ss..uh.AplsupLLsssF.ss..s..........................................	0	17	48	58
+11670	PF11837	DUF3357		Domain of unknown function (DUF3357)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2464 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 96 to 119 amino acids in length.	27.80	27.80	27.90	27.80	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.59	0.72	-4.20	35	152	2009-06-18 12:11:01	2009-06-18 13:11:01	3	4	62	6	22	158	0	103.30	29	16.65	CHANGED	hsshshp.YsP.LPssstsss.s...........+RRsh...pshsslhsullhLhhllull.............sspssssst...sss.ssspssss..............SRGsspGVSEKSsss........hsus.ssuFsWoNuML	...................s.....t.YsP.LPsssssutt............++R.......tshsslhsushlLhslsshh................stssss.ps............tss.pssts...............SRGsspGVSEKosss............hhuu.ssuFsWoNuML...........	0	2	11	17
+11671	PF11838	ERAP1_C	DUF3358;	ERAP1-like C-terminal domain	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2558 (release 23.0)	Domain	This large domain is composed of 16 alpha helices organized as 8  HEAT-like repeats. This domain forms a concave face that faces  towards the active site of the peptidase.	23.90	23.90	23.90	24.00	23.70	23.80	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.01	0.70	-5.19	123	3372	2009-06-18 12:17:03	2009-06-18 13:17:03	3	33	1415	15	1516	3073	300	295.80	18	35.56	CHANGED	hlhlNssshuah+lpa.sscphsplhp............tltpht....sshsRshlhusshshsps..........GphsspshlsLlp.....th.....ssEs-.......hsVhspllsplsshttshh.hpspttpp.hpp...h..plhst.hhcpl.uhp.s...........sshphthl+shhhssus.........ssts.hphhpshls...G.sps............slss-LRhslhsslstt.Gs..tpt.....hpplhp.hppss....................o.....sstcptAlpuhuthsssplhpc.shshlhs.....s....s.lp....sps.lthshtGh.............t.sspp..phlhsahpppa.-pltph......hsstss..hhshhltlhssth.......s..........stctlpplcpah..p...........sct...stuhc.Rsltpsh-slp	..............................................hlhlNssph..uaY+lpY..cspth.pt.lhp.........................tltt.p.................l.s.s...h..sR.stlls-hhslscs..........upls.hsp.hlsl.lp.....hh......tp.Ess..........hhsh.ps.hh.....p..t.l......s..h....ht.hhh......t....s....s..t..hpp.......hpp...........................hh.p.l..hpt.....hh...p....p.....l...uhp.st.................................................psh..t.pt..hhR..sh.hh..shss....................t..ts...hppu..tph.h.p.t...ahp...........s.....s.......................................slss.s...lR...h..l.htshhpp...us....tpt..........hshl.hpph.p..p....ss...................................s.....ss.t+pph.htAL.....u....s.s........p...........s............st.h..l.pp..h.......l..p.hhhs......s............p.....lp.....sp-...h.hthh..t.s.h..................h...ssths.phhhsah..p..p.pa.p...h.l.ph........h.stts........hsthl......t.h.hsph.h.t...................stp.p.htphctah...p............t........................................................................................................................................................................................................	0	434	694	1236
+11672	PF11839	DUF3359		Protein of unknown function (DUF3359)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2625 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.	28.40	28.40	28.40	28.40	28.00	28.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.26	0.72	-3.65	2	169	2009-06-18 12:27:18	2009-06-18 13:27:18	3	1	117	0	29	87	0	84.90	74	98.60	CHANGED	MpplL.hSulshuulLAsGCuSlocp..............sEttlouspssAspu.uRAsEAYtKA-EALAAA.tAQpsAsEANE+AhRMLE+AShK	..................MNNVLKFSALAL.A.A.VLATGCS.S..sS..K..E........................TEARLTATEDAAARuQARADEAYRKADEALAAAQKAQQTADEA...NERALRMLEKASRK..............	0	8	13	23
+11673	PF11840	DUF3360		Protein of unknown function (DUF3360)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2754 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 489 to 517 amino acids in length.	25.60	25.60	26.40	27.10	25.00	25.50	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.75	0.70	-6.16	11	257	2009-06-18 12:32:27	2009-06-18 13:32:27	3	2	199	0	48	167	14	447.20	65	98.72	CHANGED	MSss........................ppsSYpclH+PuSEFpTR--YL-HELpIMpPKRW+lNLPhRDaRFEhEDhVPAhAATIGKlVMVuAlsAAFAush.......GLusEFVlENVRYELLIAulLFVILhSGFLNPsANLAGTHGPhIPLIPlIsAAGGHPLALGIhlGlFGLlLuloKGGShLspLTScGVsGGLLlYLGFlGhhSQlpKLhuWAsuh........uMualuFVVIhsTIllYAhLt+hpKRWLAIPLsullAullAFuMGAPF-..FsTpPGLPNhsPhYWWGE.sTGWpLGLPslpHFIAVlPFAlLAVAMWSPDFLGHRVFQcLNYPK+u-+VLMslDDTMTssSlRQhVGSlLGGGNluSSWGTYMIPAAIAKRPIPGGAlLTGlhCllAAlhGYPMDLAlWpPVLsVALlVGVFLPLLEAGMQMsR-sKsoQSAuIslFuSAlVNPVFGWALTMLLDNhGLIGsKERuspLohhcRhlIPsssFllhsuuMuhVGMLP...GIPAlL	..........................-h.cspoYc-LHRPuSEFtoRs-YL-HELQIMpP+RatlNLPhRDaRFEhEDhlPAh.AGTIGhlsMhuAlhhuaAssL.......sLu.cpFslEssRhEhLIsAl.FsllhSGFl.PpANLAGsHGPhIPLIshlshAGuHPLAhuILlGVFGLlLuhhKGGShLssLTSpGssGGLLlaLGFsGThuQlppl.pWAsGl........sMuYIuhlVlhlsIllYAhLt+hpKRWLAlPlsshhuhllAhALGAsF-..FpTp.GLPNhsPsYWWGp..ppGWhLGhPshpHFlsslPFAlLAVAMWSPDFLGHplFQclsYP++TEKVLMslDDTMThCSlRQhVGohLGGuNhTSSWGTYhlPAAIAKRPIPuGAlLhuhLshhhAlhGaPMDlAlW.PVhpsALlVGVaLPLLEAGMpMs+csKs.oQuAuIslFuSAlV..NPVhuWALTMLLDN.GLIGsKERuupLShhs+llIPusshlIhhhAMhAVGML....Gl.Ahl........	0	10	18	34
+11674	PF11841	DUF3361		Domain of unknown function (DUF3361)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2780 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 154 to 168 amino acids in length.	27.20	27.20	27.60	28.50	27.10	26.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.92	0.71	-4.52	9	228	2009-06-18 12:35:40	2009-06-18 13:35:40	3	3	88	0	122	212	0	153.90	50	23.12	CHANGED	hTFAtEFIpccGLthLhpllEsusc............hu............-hLsasLoAFlELM-HGhVSW-hLosoFI++lhuaVs.psth.csollppuLuILEshV.sSsslathVtpElTltpLlphLps.sspplQspAIALlNALFlKAs-s+Rp............phAsslupKpl....RthIhssllt	........hTFApEFIsh-...GltlLsp..hVEsGoc..............hu.....................................-hL.uaoLTAFlE.LMD..H.G.IVSW.D.hlSlsFIK+IAuaVs....pshh..DsSIlQ....pSLAILEShVL.N..........SpsLYppVup.EITlspLIsHLQs....osQp..IQThAIALINALFLKA.s-.s+RQ........................-MAshluQKpL....RslILsplI+................	0	26	35	68
+11675	PF11842	DUF3362		Domain of unknown function (DUF3362)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2839 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 117 to 158 amino acids in length.	27.60	27.60	29.10	28.30	27.20	26.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.01	0.71	-4.30	9	1200	2009-06-18 12:37:54	2009-06-18 13:37:54	3	3	1181	0	232	851	107	136.70	46	19.49	CHANGED	DQVQsFYPSPMATATAMYHSsKNPL+KVsRc.....sEsVDIV+GEKpRRLHKAFLRYHDPsNWPlLR-ALKpMGRADLIGsGKpHLIPsaQPh.sDG......uYQSAR+KNSo.......................................ssG..shps...........spspKG+hLTQHTGLPPRsss	.DQVQsFYPSPhAsSToMYYTGpNPLt+lt.a.c......oE.cVhV.PKG-+QR.RLHKALLRYHDPsNWPLlRpALctMG+c.cL....IGsp+cCLV...Ps..........ss....hc.......................ph.pp...u..R..+..p.spp...........................s.t.st...h.ttt.................................................................st.sttttttt...........................................................................	0	66	143	189
+11676	PF11843	DUF3363		Protein of unknown function (DUF3363)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2310 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 323 to 658 amino acids in length.	28.40	28.40	42.40	30.30	25.60	24.80	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.27	0.70	-5.82	40	413	2009-09-14 15:03:38	2009-06-18 13:59:04	3	5	192	0	169	399	41	221.20	32	58.09	CHANGED	LhlGRLp+LEchGLApphuPGpWplpscsEssLRcLGERGDIIKpMHRAh.stcGh-..Rssusaslcspt.s..sPllGRLlsRGLc.DELpspuYsVVDGlDGRsHHlclsch-ssucsss.GuIVElRsh.s.......................................................................................Dsptppp..lslssRSDLsLppQlsAsGATWLDRphluc-s.sLut..uGFGtEVRpAhcpRs-+LhspGLAcR.pupRllasRsLlsTLRcRELsssupcLuucTGLsaptussG-pVuGsYRp+lsLASGR.FAMI.....D.....cGLG.FpLVPWpPsLE+pLG+cVoGls+ssGGl-WshGRcR.GLGl	......................................................................................................................................................................................................................................................................................................................................................................t...h.lthho.hslttQht..usTWLDpphlttt....shs......GF....Gt..psp..tAhttR.thh.tpt.App...ptttl....hhttshlthLctpEltthutphu.t.u..h..sttGp.ltGhhptph.LuSG+.aAhl.....-.....puht.FpLVPWps.l-pplGppl.uhhp.ssulsWph..uRt+.u..............................................................................................................	0	24	107	141
+11677	PF11844	DUF3364		Domain of unknown function (DUF3364)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2336 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 60 amino acids in length.	27.40	27.40	27.40	27.40	27.10	27.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.77	0.72	-3.94	40	333	2009-06-18 13:02:42	2009-06-18 14:02:42	3	3	292	45	92	315	8	54.70	45	14.47	CHANGED	MsQss-.......+lhDHhsLF+cPEYp-hhpsKpcpFEssh.ssccVscltEWTKTWEYREKN	............MsQ.osE.......+lLDHspLF+-sEYpchFpsK.ppFEsst...sspcVpclhEWT+ohEYREKN.	0	24	57	72
+11678	PF11845	DUF3365		Protein of unknown function (DUF3365)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2563 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 198 to 657 amino acids in length.	27.80	27.80	27.80	28.00	27.50	27.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.67	0.71	-4.44	153	684	2009-06-18 13:07:17	2009-06-18 14:07:17	3	87	394	0	307	670	98	181.10	17	39.40	CHANGED	lhhshlh........hhhhhhhhh.........................h...p..pts..tppshpp.Acshhpph...............shRp..........asspphtsh..h...................................shthshhs...........P.uhhsppl...tc.......thsp.tt.s..hhph+hsoh..pspNPp.NpsDs.aEppsLcpFcpss............tphhph....su..pphh+hhp..P..lhh.pps..CLpCHu......t................t.thsaclG-lpGuhslsl.Ph	.............................................................................................hhh......h....h.hhh...h....................p.....t.h.....t..hh..pp..uphhhpth...............t.h+p..........ahsphht.h..h........................................................................s..hth.s....s.shhshpl...tp........hsppt.s.......hph+hsuh...ps...pNsp..stsc.....s..aE.pchlcpFppst.................t........ph.p.....ss...pshhRhhpP..lhh..pps..CLpCHu....t.t.......................t.saphG-ltGshslphs.....................	0	130	249	287
+11679	PF11846	DUF3366		Domain of unknown function (DUF3366)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2678 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 200 amino acids in length.	27.90	27.90	27.90	30.10	27.70	26.80	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.36	0.71	-4.43	29	415	2009-06-18 13:09:44	2009-06-18 14:09:44	3	5	380	0	90	371	29	192.40	21	34.03	CHANGED	lhhhullhslslHShLEYPhaYuhFhlshhh.hLhhh.s......sth+...hshphs......hsLt...shsllsshhhshhhhp..shppsphL.ha.....tspsss.....hppsssshhatp..sas.hsshh.hsh.p.tssshhhshhphuhclh...P.....psshhpph..hhuhshhGcpscA..............pphhppsphlas......................hppapsh...hpphstssss	........hhhhulhss..lhlHuhLEYPhaashhhh.hhl.lLhhhss............pth+..........hhs.hsth..................hhLh...s.shhlhsl.lshhhhhp....sh...p...p...s.phL.st..ap....tspshs.ph.....hppsp...shlh.t.pp..tashaushh.l.sh..tpppsphhps.hhchuhphlp.pP.....psshhpph..hlhhth.GcpscA............................cphhpphphlaP..........................................pth........................................................................................	0	15	42	65
+11680	PF11847	DUF3367		Domain of unknown function (DUF3367)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2726 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 667 to 694 amino acids in length.	26.00	26.00	26.00	33.70	25.90	25.40	hmmbuild  -o /dev/null HMM SEED	680	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.20	0.70	-13.27	0.70	-6.58	14	220	2009-09-11 09:45:00	2009-06-18 14:11:38	3	6	191	0	63	201	18	617.40	44	51.49	CHANGED	llhhhlsFtQsPGplusDTKlDLslNPhtFLsRAhahWssshshGQlQNQAYGYLFPpGsFFhlschLtlPsWVsQRLWWulLLsluFhGsltLscsL......slGuss.sRVlAAlAaALSPRlLTsLGulSuEshPhhLsPWVLLPlltsh+.....................................ssRRhsA....hSuLAlshhGuVNAsATlsullsAsLalh..stt..pRhhph.huh.Wh.....hulhlAohWWllPLLlLG+YuPsFhsaIEouusTTshhohsElLRGsssWssals....sthsAG.tpLVssshhlhsTshVAulGLhGLshhthPtRthhsshLhsGlslluuuahst.suPhup.VpsaLDG..sGssLRNlHKh-sllRLPLslGLApLL.stl........slsh.ushtth...hhp.th...........t+hAsslhslhllssusuPAaoGclhss..GsapcVPsYWp-AA-WLssc...ssu.o........RsLllPGusFup.sWGpo.hDEPhQsLh-sPWuVRDulPLssPtsIRhLDul-ctLpsGtsssGLussLtRt.GluhVllRsDLsscsstsshsh.hh+pslt..coPGlspsts.FGsshtsssh........hlsDsshcs..hh.ul-lap....Vsss..........sssss..hthssscshhhVsGusEuLhpLsusshhtst.....................usslhsu-.t.ppss...ssss....ssoDsstspcssaGp.....sssssushhsss..................-....spsshshlss	................................sshhlsFsQsPG.lusDTKhDLssNPhpFLucAhphWssphshGQhQNQAYGYLFPp...GsFFhluchLt...l.PsWlsQRLWWulLLsluFhGhlRlA.ctL........ulGusu.oRlluAsuaALSPRlLTT.LGuISSEshPhhLAPWVLL.Phlhsht...t............................................sstthAAtuulAVAhMGAVNAsATlAuslsAslahh....................s+t...........s.Rh....hhRh...huh...Wh......huhsluohWWlhsLhhLuthSPPFLDaIE..S...usVTTpWhSLsElLRGTsSWTPFVs.....sptsAG.tsLVTsshhl..luTshlAA...hGLsG.L...s...h.t............hPtRt...hhlhhLhlG.lllhss.uahut...suPhut.lpsaLDu..sGssLRNlHKhsPllRLPLsLGlAphL.u+l...................sl.stssst.t....hhpspps............................+plAssllslhslhsuso.AWoG+lhPs..GsastlPpYWpcAA-WLspc..ssss.................RsLVlPuAsFApQsWGho.+DEPLQsLhs.s...PWuVRDulPLsPPtsIRuLDuVpphhssGtsss.....GLus.sLtRt.GluhVllRsDLDscsspostsh...lh+pslt..tsPGlt+l.spFGsshssssl.ts......hl.-sshcs...thsAl-lap...Vsss...............sssus...shhssscthshVsGuP...EslhpL..sp..p..tth...u............................uPslhsuD.u...ptsuh.....ssst.....sloDsshsR-s-aGp......lsspsSshhuss......D....hptshsh.........................................................................................................	0	14	44	58
+11681	PF11848	DUF3368		Domain of unknown function (DUF3368)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2745 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is about 50 amino acids in length.	27.30	27.30	27.30	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-7.93	0.72	-4.40	50	241	2009-09-14 14:59:35	2009-06-18 14:13:08	3	2	142	0	94	302	28	47.90	28	32.24	CHANGED	plpGTLGlLltAKpcGlIs..pl+sl..l-pL.ppsGaalupplhpplLppss	....lhGTlGlLltAKppGlIs..pl+sh..lcpL.ppsG.ahlupplhpplLphh...............	0	32	74	88
+11682	PF11849	DUF3369		Domain of unknown function (DUF3369)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2927 (release 23.0)	Domain	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 170 amino acids in length. The domain appears to be related to the GAF domain.	25.00	25.00	25.10	26.00	24.40	23.40	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.79	0.71	-4.32	63	346	2012-10-02 14:34:25	2009-06-18 14:16:17	3	20	234	0	123	289	44	170.90	27	29.85	CHANGED	lhouLRSYcsIpsI-psRp.......GLE+llcAousLh..phcolppFusGlLsQlusLLsls.ssulhs.................sspss..........tpp......tt...hpllAuoGp.asshhsps......htt....hsspltphlppulpp.+psla.pcsthlhYhssp..s.spphllalcst.psLs-h-ppLl-lFspNlulua-NltLhpclccs	............lhouLRoYcplptI-ps+p.......GLp+llcASuslh..p.t+olppausuVLsQlsuLLslp..ssulhs............hshpss....................spp.....tt..hplluusGp.apt.hhsps........htt....lstcl...tptlcpslsp.....+pshh..tssthlhahpsp..p...uhps..llYl...pst...p..pLs-..h.-.cpLl-lFstNluluF-NltLhpcLcc.............................................	0	38	66	86
+11683	PF11850	DUF3370		Protein of unknown function (DUF3370)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3037 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 452 to 532 amino acids in length.	25.00	25.00	67.30	67.30	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.38	0.70	-6.02	31	109	2009-06-18 13:19:48	2009-06-18 14:19:48	3	3	55	0	43	130	73	441.60	43	92.32	CHANGED	shhlsss.......................shhtsstssssthss....p........QclRPLPGpLssVPVlNSNsPElVpu-GILlSTFPs......ttptpPtspL......sasFsGRFDlFuHHlatspsspch.....cs.LaLullstNPuspPVTlplhpGuopLS......ps-APFlsLPshhscshG..slhuGPGsRsus-lL.RGcpstcLPsp.lsIPPtptphLlsLPIPlpGls.......................................NGRshhlRhcSsGPlhhAslAthu........................psPo.pcWhslLpsGpLu.sR-ahPoPh.....thpsthIYSRVAGVuhGopWpAploD...ttt.L..shsstslSaPloSLp+GphGTsQlQoA.LhsRhPDTAasAHGNYGVcYDLsLPLpNsusp..slpLsLpoPlKssc....tttLhF.t..ps.shFRGolclcht-sttt.....+hlHLs.RpGQ.G.sLsplsLpPGcp+pVcVsLlYPADATPPQVLoVhPlp	.........................hhhhhhh...........s...hssp.ls...psQplRPLPGpLDslPVFNSNSPElVpsEGILLSTFPs......pscthPsAHL......NashpGRFDlFuHHlspspsspch.....co.LYlGllstNPu.spPVTlclLpGuSaLS......psDAPFlsLPshsc.sspG..sVauGPGSRlssDlL.RG.......pppsphPsp.llIPPspschLlshPIPlpsls.................................................NGRSshhRLp..Ss..G......s.......lYhAsLAhau................................p..sst+sPoLp-WpsLLppGpLu.PRDhhPTP......tsssphIYuRVAGVuhGSpWpAplsD.s.ttp..hLt..lPtsGpuhSYPlSolptGshGTsQlQoAshhsRYPDTAYpAHGNYGVcYsLoLPLhNsospspoVslsLpTPlKpsp....pstLhFhpsssstlFFRGoVclpYpDcput.pp..RahHLVQRpGQ.GpsLlplslpPGcpR.VpVchlYPPDATPPQVLTVpT..p.....	0	2	25	39
+11684	PF11851	DUF3371		Domain of unknown function (DUF3371)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3115 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.	25.00	25.00	26.60	26.70	23.30	24.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-11.07	0.71	-3.46	20	373	2009-06-18 13:21:43	2009-06-18 14:21:43	3	4	107	0	112	312	0	132.00	43	32.44	CHANGED	hQARAHGL.sshsSsuls...os-Lss+l..lKQpssh-c.............................................ssp....c......lhs.p.tppPphssss.............sLDls...........................-GshsFsDsLss.sspshshu..hptpp.cL--lLMDD..........sLSPl..uoDPLLSosSPs..uSKsSSRRSShShEEs-	......................................................................................................................hQARAHGL.shhs.SsGls......os-Lss+l..lKQEsslEp...............................................sspp.................hh...p....ts...shssss...........................sLDLs.................................-.Gshs..Fs.ssLu.stss....s...s.hshu...p.tp.cL--.lLhDD...............oLSPl..soDPLLSohS....Ps..ASK.s..S.SRR...S.Sh.ShEEs....................	0	4	14	44
+11685	PF11852	DUF3372		Domain of unknown function (DUF3372)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3259 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This presumed domain is about 170 amino acids in length.	29.70	29.70	30.50	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.88	0.71	-5.11	37	294	2009-09-14 08:08:02	2009-06-18 14:23:36	3	29	264	8	103	277	30	163.90	36	13.66	CHANGED	ohpsNN.WsVGLPhtp+stssWshIpsll..sssshcPsts-IttspphFpElLpIRpSSsLFRLsous-I.pRVsF+NsGssQhsGLIVMSI-D.G.sts...........tslDsph-ulVVlhNuosppho.hsls....shs.u...apLHslQtsus..Dshltpu.sasss......pGpFTVPAhTsAVFVpsp	......................t.hpsNNaslGLP.tscst...ssWslhcsll..sss..shcPsss-Ittssshap-LLplRpSSsLFpLsouscl.pRVsF+...NoG........s.s.p.hP.GlIVMoI.....-D..u.tts...........sslDsthsulVVVhNAospsho.hsh.........shs..u.....apLHslQs..suu....Dsslp.tu..shssu......sGphTVPAhosAVFsp......................................	0	29	62	92
+11686	PF11853	DUF3373		Protein of unknown function (DUF3373)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3442 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 472 to 574 amino acids in length.	28.00	28.00	28.50	40.80	27.70	27.90	hmmbuild  -o /dev/null HMM SEED	489	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.81	0.70	-5.96	18	144	2009-06-18 13:25:15	2009-06-18 14:25:15	3	2	135	0	39	127	11	496.60	45	99.04	CHANGED	MKphhphhlsush....hshohshtutss-hsh.p.cl-pLppclppLcpQht.................thppplpchEc..............+ohuchLphuGDaRa+lDulch+..s.....................................................h.th...s.....................................................ssutcscN-slaTNRhtLsh+AKsocclohpuRLsMYKsaG.....t.ssssspsaauspsh.hhDGshscsPo.sshLpV-cAYhsWpN....IuDpP.hahSlGRRPSTsGsPupLRpNpp+sus..sPuhLlcasFDGhTlGas....s-.lsulsG.sasKlCYGRGF-su........assst......NshcDTDhhGhsllPhDssshplphpa......s+uaN..lhshPs.hss.F.................stsssssplGsl.sahGhuhh.phcslGsG......shshFsShuhSpTpPsss.........h.hssh.....puhLsus..............ss+TGausYlGscash...ssssKhGhEYN+GSKaWhoFs.PAtDDhhsSKluTRGssaEsYhIpEL........hs+hFh+LuapYYDa-YTGSNsalGA....PhKIs-lpus.h...hhs.......................................slcpApDlhuohcl+F	..........................................................MKThhSLlLuAsL....LooSLhAc.ss-DElspLQpQLAplpuELApI+cEp-spscpsp...............................ssptclADLNDR.s.DcTEh..............pAALs+lKFGl-FpTuVsNhsYK.......................................................................................................................................................................................VsGQDhssN..shahNcL+LNMsAclNDcscFaGRLSMsKNWu............QhGaSussh..sLDuspNspo.S.GssLhVDRAYhDYh.....Issp.WhsolGRpPuTDG..PsSNLRsNuLRpST..hPA.LsINshhDuAslsYc....PEsL.p...-ac......sslRhsYG+saphspt...............hhcWhusppsuD......sNlhhsss.....GtLsI-uhsDshlhh..slsa......hssFs.......l.shsshh..ss.h............................hpsssssNLGDl.sluslpFp.shc..uhGs.......NFNaFsSLGaSpusssph...............sshh......puh.Lpsp............t.s-cDGYAVaVGuRYDh.....ocuhKlGaEa.aGS+YWhTMo.PuhsDPlsh+h.TRGsAa-hYlIapL........-chtFlRLSYTpIp..auspGhPF.Gu.....sKh...DcucAssh......MhMh.......................................sVK........................................	0	14	32	36
+11687	PF11854	DUF3374		Protein of unknown function (DUF3374)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3548 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 665 to 712 amino acids in length.	20.70	20.70	20.70	20.80	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	637	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-12.94	0.70	-6.27	30	127	2012-10-03 17:14:37	2009-06-18 14:29:26	3	2	73	0	59	117	34	615.40	28	90.44	CHANGED	Gas-sDDh+..tuNsa.......Gs.psGhsutlsADlpapscs...GYpsplpAcpLGh-suphplpsG+.GpYplsL.sYcpls................pYpsssshos..............a..............WhssG..........hsthpssl....ssh-LslcRc........+hulGhp....Yps........shapsalp....Yp+EcKpGp+...p.......uShshh.s.ps...................s......lucPlD.toTcplsAGlphpG-s.....WhsslsYpGShacNchssLs.....hssshssh...............................s..AhsPDNpAHplulsGQYphs.pophsGRlshGpMoQDpshlshs......................ssPh..pshDGpVDTlshslphoo+lspcL+LsuuaDYsDRDN+oss.hpasQhph..........ssls.Gtst.....NsshDpp+pphclsusYRls+sh+LpuGY-acps-Rott-............REpTsEsslau+hph+shsshshtlKuuausRsGScYpss.phou........upsNsLLRKYY...L.ADRcRsplchcssa.....ssh-sLolshsscYupDDYsc.Tp.lGLTEucDhGYDlsluatls-clslpAFhspQaI-.......SsQu..GSsshusss..........W...puslcDchsslGsGhsYs...sLh-s+LsLGhDYoaSsSpScTpl.............spshsssYGDYaupsHs....lphaupYplo-phu..........L+LsYpaE+YpDsDaup..lss......suIs.....slhohGslsHsYsAHhlhLohSYpL	..............................................................................................................................................a.st-s.p..tsNth.......us...psthhutlsuDlp...h...pspp.......GYpsplpAppLGh-sshhplpsG+.Gpaplpl.sYppls................pap....sssshos..............a....tt.......h..........hhss..u..........t.....................hshh.ssl.............ssh-LulpR-........+hslGhp...aps........tshapshls....Yp+Ec+sGt+......p...........sShshh....s..ps...................h..........lscPlD.toTcplpAGlphtGcp.....W.sslsYp.s..Sha+N.chs..s.Ls.....apsshsss...............................h................st.uhsPDNpuHplu...lpuph...shs...psphsu+lhhupMoQD....pshlshsh.........................thPs.....pshDGcV-hhths...lphsu+lop..slplsuuac...YpDRDNposh..tasp.h.h................................................sshs.Gtst......NssaDhp.ppphc..lsusYRlspshpLpuGYcacps-Rsht-................................Rc..pTcEsslau+hphpshsshshhlKspaupRcGSpYpss..thop.........................upssshLRKa....L.ADRcRpplchcssa........................sshpsLolshssphs.DDYsc..ot.....l.GLocscsh.u.YDlshsa.lssslphpAahspphh-.............ScQu...Gussh.usss............................................................W....hsphc.D.cs..sslGhGhsap...sL..h-s+LplGhDY....oYSsup.SsTpl......................ttuhsssYsDhhup.Hs......lphaupYphs-phu..........l+lsapaEcYp-sDatpp.hs.......ssls......sllshGs.hspsYsAphlhlohsYph..................................	0	9	23	38
+11688	PF11855	DUF3375		Protein of unknown function (DUF3375)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3589 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.	25.00	25.00	26.50	30.10	23.60	22.90	hmmbuild  -o /dev/null HMM SEED	478	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.43	0.70	-5.75	28	246	2009-06-18 13:31:11	2009-06-18 14:31:11	3	2	231	0	95	249	38	458.70	24	95.80	CHANGED	lptlR..pcpPAWRLLtuppAPllluhLcphFh.ssspslPps-LtptLccpLtsLccpttp.........tthPps....ApsYLs-Wst..p...GWL++hhsp.sss.-spa-LTsssccAlpalssLpppp..hsuTESRLtolhptLcpluptspsDPctRltpLccc+sclctEIsclcuG.clshhDssplt-RhpplhphucpLhuDFRcVccsa+pls+plRcclhs.pus+G-lLcplhsphDs.ltsS-pG+SFcuFachLhssspppclsphlcplhsh...stpLcsctR..Lpplhtchhctu-cVpRshp+hucpLR+alcspshhEsR+lhplLpphpstAhsh.....pct...sthhhshsthusshphshpp.hhpsPs.......psthsshsh.sssssch...shsshhststlDhpclttt.....lppsLt.pps...pholucllpphP.hppG..LuclluaLplAt.........ptsh......................lscppppplpapst..sGh....hRpsplPplhhsc	...........hR..pcpssh+LLtuppuPhlluhLpphF..stpttlspscLhppLpcpLttLpppttt............t.hsps.......ApshlpcWsp..p...G...WLp+hhst..sss..c.........hacLTstucpAlcalpsL...p.ppp..hsuTtSRlpslhptLcplutpsssDPppRlttLccchpclctEIpclct....G..p..h....shl-spphh-chpplhphucpLhsDF+cVppshcpls+plRcclhs.....sct....spG-lLcplhsth-t.ltcS-pGRoFpuFaphLhssppppplsptlcplhph..hht.tLssp.Rt.l+plhtclhctuppVpcshpphucpl+palpspshhcpRplhplLpph.stAhsl.....ttt........t.thhh.ht.ths.ssh.h..s.ltp...hhpsss.......pst.h.s.sh.h..tsssssl.s...shsslhspstlDhtpLtpt.......lpphlt..pps........lolupslpphP..pps..LuclluaLslut....ptsh.................................sspsp.tphlpaps......-Gp.........RphplPtlhh...................................................	0	24	63	86
+11689	PF11856	DUF3376		Protein of unknown function (DUF3376)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3667 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 770 to 1142 amino acids in length.	25.00	25.00	25.90	25.90	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.73	0.70	-5.13	23	113	2009-06-18 13:33:06	2009-06-18 14:33:06	3	3	102	0	35	96	6	449.00	32	49.25	CHANGED	hsslhuuluslPRppsh+spLttlpt.spphp+hcplhsuhRschppthpp...........thu...shhtsp.pstcLpthcscstptt.....shttshsatshhpsclst...hlctlspllsths.ttsssp.tttthpshhtph.t.........thsslsshps.sstsshtthhpttc.....hsh+hRRLphlsccLs.................csh......csssstc..........ssslsttcpslhshl.t.ulhpstcthtt...............hucshpc.lsssshsh...........ss......plhchlsphth..............t..pshtthctpu..-phLus.hltthsp........sh+tpl....LhsYL.u....asaaDlsshPhh..tstsh..sphp.lplsRISP-DAso..lpsssst........spLtGhphssFGAFhsRuaRcNDalWGRLcGA-Rllcllhsstc......................................................................................................stls......-hshhs......................lc+..ptFhslLcEEhspLh...........................................................................................................phs..............shlusLcsp.....ss	.....................................................hpsIhup.ssh.tcpss+.cLtplttp.c....pthphlssuhhschcpp.sp...........t.u...slh.shhphhphss.cstssppu......h.tuauhphhst.schst............lscp.hshhh.hhsh.....ttsssp.shsp...stltph................stsshshs....pu..sshsshtshhphtc......shclttLt.lsctlp............................psh......css.ssts............sslst.hhssh.shht..sl.phtcthtt...........................................usshpp.lssshhss............s......sltphhsshss....................................................t.sL..hthcths..st.Ltp.hlshLss........p.t.ph.......hhthh.s....hsh.hphshhPh.....tt.c.......slclsplSs-stsh..Lssshps........pKLsGhpLtpFGAFapRuWRtNDahWGRLDGAshLVclLLsspc......................ht.................hhtthspptt....t.ttphhhs.hpp.tt...h.t.t.................................hhs......-hshhs....................st..ltt...th..plht-Ehstlh................................................................................................................................................p.............................lupssstst.hht.h.........................................................................................	0	13	30	34
+11690	PF11857	DUF3377		Domain of unknown function (DUF3377)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3829 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 70 amino acids in length.	25.50	25.50	26.00	29.40	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.53	0.72	-4.35	20	249	2009-09-11 16:26:36	2009-06-18 14:39:46	3	11	47	0	110	190	0	73.20	44	12.91	CHANGED	sssscccccthspDs..s-lllcl..D....-s.suossAlAVVIPhlLsLClLsLlYsllp.F++KGTPR.................+lLYCKRSlQ-WV	..................s...ttc.-tttspDc.....scIllcl..D....-s...uuoVsAlAVVl.P.slLhLClLsLlYslhQ.F+RKGsP+.................plLYCKRSlQEWV.	0	4	15	44
+11691	PF11858	DUF3378		Domain of unknown function (DUF3378)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3989 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 80 amino acids in length.	27.00	27.00	27.00	27.70	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.64	0.72	-3.92	33	937	2009-06-18 13:41:57	2009-06-18 14:41:57	3	2	910	4	78	516	5	78.90	34	26.11	CHANGED	sshVl.pssppplpphpppYtshhssphsssshFtAKhsssoIosYpSGKVlFQGpsAEp.Au+a.th.spppttsssssspsh	.........................sIll.phopcsIpshhppY.ps..h.s.s.sts.shhpahuKhsssTlolY.pSGKVhFQGp...pAEthAspa..th.st.ppptt.t.....s.....................	0	18	35	60
+11692	PF11859	DUF3379		Protein of unknown function (DUF3379)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2469 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 234 to 251 amino acids in length.	26.50	26.50	26.80	29.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.45	0.70	-5.19	25	166	2009-09-14 14:58:51	2009-06-18 14:53:41	3	2	162	0	38	115	10	236.60	48	98.12	CHANGED	MDELEFRR+hhuDPpspDs-hLpthppsspcppFls-lppLDt+lppALc.VDVPDDLADKlLLpQ.....phppcp..........spR+p.s+h.tlAlAAS...VAFssGlhh..u.lphus...............ssLu-pALuHVaHE.s.hshphDcslshppVNAKLushusphstcF...PG+VaYssaCcFpG.s+uLHLVhQGcpG.KVTLFIVPlcschsh.t..sFsDsphpGhshtsssAshlLVGEpupDLshlpcclppshh	............................................MDELEFRR+lhSDPKp+Ds-hLshhsuS-uNsKFlDDlLpLDppIspAhK.VDVPDDLADKILF+Q....lc-.c+.................llRPpFsR+.AMAlAAS...VAFsAGLll..GQlpWGNhhl........sPApASLu-hAlpHVhHEcs..FVpcl.DEpsshpQINAKMtPFuhphpucF...PYHVYYLNHCGFGc.sNAlHMVFQGE+G.KVTLFlsPIcStpss......tFppcGMsG...llpPl.usASlILVGEcsEsLsslAp+Lhshlp................................	0	6	14	26
+11693	PF11860	DUF3380		Protein of unknown function (DUF3380)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2757 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 194 to 284 amino acids in length. This protein is found associated with Pfam:PF01471.	41.90	41.90	41.90	42.20	39.00	40.60	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.24	0.71	-4.23	35	230	2009-06-18 13:56:43	2009-06-18 14:56:43	3	11	203	0	58	211	23	167.30	36	58.52	CHANGED	lphAslhAVscVESsGt.GFh...s....ss+PtILFEtHlFaRpLtt...........t..stphssphssls...s........p.tGtYts................usuca..............pRLcpAtulsp.....cuAhpSsSWGhaQlMGa.paptlGY.sSVpshscsMpt.uEspQLcuhl+Flct....ss.LhcsL+s+c......WssFA+tYNGPuatcN..pYDtKLspAYp+as	............................................................-.AslhAlscVESsGp.uah........sstcPtILFEtHhFhRplss............................................thhs.pts..sls...ss................p.tGtats..................tstca...............+LppAhslst.....cuAlcSsSWGhhQlMGh.pa....phhG.Y.sSVpshVsthpp.u-stQlchhl+FIct...............st.LhpAL+..s+c......WssFA+tYNGPuascN..pYDt+l..scAap+a.................	0	12	32	44
+11694	PF11861	DUF3381		Domain of unknown function (DUF3381)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2792 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 156 to 174 amino acids in length. This domain is found associated with Pfam:PF07780, Pfam:PF01728.	25.00	25.00	34.50	33.80	22.80	23.20	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.10	0.71	-4.73	39	321	2009-06-18 14:02:02	2009-06-18 15:02:02	3	10	278	0	238	322	5	161.80	31	20.48	CHANGED	lhps....c+K++pRpGY--GDhhl.a+phslh-Fl+s-..cPl...shLuphNclsh............cD.thchlpchcpTTsElhpChcDLKVLG+K-F+tLL+WRpplRchluhspt................ppcpt.......phElcthsEEppl-..cElp...p..hhE+pptct+.+c++cpscpKp.....K-ll+.Qhphh	......................ppKKpKt-GY-EG.D.hsl..a+phsss-Flpss..sPl...shLup.hsclsh.....................................................sD..t....ptlpcp.tTTcEI+tCCcDLKVLG+K-h.+t..LL+WRhcl.Rchhuhphcpptt................pttpp................................tt-s.pshc--t.plp......c-lp.......p....hhccp..t...tc.hK..+..cc++..c.pc+Kp.....Kchh+.php.................................................................................................	0	84	133	200
+11695	PF11862	DUF3382		Domain of unknown function (DUF3382)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2882 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 100 amino acids in length. This domain is found associated with Pfam:PF02653.	28.90	28.90	29.40	29.40	28.70	28.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.22	0.72	-4.10	45	897	2009-06-18 14:04:04	2009-06-18 15:04:04	3	5	808	0	148	478	130	101.60	41	23.71	CHANGED	hspsL+pAlhuAllshllhssllGlpLp.t.GspLslp..sp.s.hhhhVuhuslshFlhpLa......+shls.tshsssp..hsslss......shsptpRhllhsLllhAlla	.......................h...plt.ALhSAshhhlLAulhhGlQL-...LDGT+LVV-sAuslpWpaVhIusAlVFhFQLl......RPhhp..+ulKsVS..us+alLPu........h-Guos.+QKlalhALLVlAVsW..............................................	0	18	50	96
+11696	PF11863	DUF3383		Protein of unknown function (DUF3383)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3017 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 356 to 501 amino acids in length.	27.00	27.00	27.20	27.00	25.80	26.90	hmmbuild  -o /dev/null HMM SEED	481	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.33	0.70	-5.82	26	463	2009-06-18 14:05:44	2009-06-18 15:05:44	3	3	282	0	49	410	14	282.30	18	97.36	CHANGED	slsclVsVslslsstuusst.shsshLlhs......psshssspphpsaoohpsVus.sFGssoscYpsAthaFuQ.....sspPsplhluRasp......s..s.l.u..ht......s.hpth.sGshplshsu...h..stlshst.hshsssAt.hpstht...........ss.hs..tttahltssssGs.....................................................................................................................hs.s.sss.huthlthpss.t....sh.s.uhss-ohspAlsshts.hsssWashthust..hsssphlAlAsahp.....ttshp+lashsspcssslsss....ssslhttlhs.sshppohshYsss........ssY.sssuhhuthhossasuspstlohta+p..sGlsu......-.slssopusALcspssNhasph......ssshuhhpcGhhsuG....pahDphtshsWLpstlpsslhslLhss..sKlPhs-sGhshLhusl.psshspulsNGhlusGh..........stshGshssGchlt.tGYalhs.ss.hsp.upssRpsRptsshphshphuGAIHpl-ltssls	...............................................................................................t....hh............................h..h....t.h...............h.hs..hh.............h.h...........................................................................................................................................................................................................................................................................................h.t..t......tah.h.........h.................tth..huth.t..............t.thh...hh..st..t...........................t....h..h.............t........hhuhh.h.sh..tt.................s..hhhpt...ul.........t....h....s.sthtth.............t...t..h.hh..........tth....httGhh.ss.....ahD.hh...ah.t.hp.th.th...h.p.....tpls.sttG.shl..s.h...ttshtthht.Ghh....................................s...a.h.........t.s.t.httR....h.h.h..usulp.h.h...........................................	0	9	28	40
+11697	PF11864	DUF3384		Domain of unknown function (DUF3384)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3114 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with Pfam:PF02145.	28.10	28.10	28.50	29.10	27.30	26.70	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.63	0.70	-6.02	26	254	2009-06-18 14:07:29	2009-06-18 15:07:29	3	12	181	0	161	269	0	408.70	28	26.91	CHANGED	pps.lspRhcthcplscu.lppa....sh....ssl.tlWpsup...DLlpsppsscs.R+suhpLLptslpppct...............................ssstRthaFcsI...........sss.sps-s..ls.......hpLpuLpsLT.....ccG+cl..sa.hppslhshlspal.shh...............t.h..t+...tpt.........ts.s....-sshlsslLphls...sll+astphhsppplttllpplhpl.CppToss.............................................................................................................................................s-l....pssLplhDulIp..YuslPspohsshlplLC...................................................................................................................................................................................................................................................................................................oh.hshs..............slspssh+.....slcNLhco+htpphlpsLpshL.......tssppp....hp........shslLR.........................GAltllphllhss...tppthst...............lphs.......lhsuhhsslc....pssstlsh-llphhpsll......tphsph.hhppsWs....hhslhsp...................................hhsphtshttstss.tp............................pplhsphpplhsp.lEpLhcp..hphp.p+c.chhpFlhpstphlssussphllthhpspphssPsss......tWlpshppllcpFh.spspssslRlpslpslpcs	.......................................................p..s.lspRhchhtplsch.hpph....ph....psl.t..lWpssp...DLl.ps.pp..s.s...-s.RpushpLLpsllptQs.p...............................hs.hhR....thaFpsI.............ps...sss-D..lp...................pLcshpsLT.....-pG+cl..sh.h-pclh.h..lhpWh.............................................................................................................................sh.sphl.hll...sllKFNtshhc.phlsth.lp..lhhl.ChpTsss.............................................................................................................................................sDl....css...LpllDAlls..YsslP.scsLs.hl....sLC..........................................................ph.hsht......................................plsps.sW+.....hh+NLht.o+hG..pssl.hshpplh...........................psps.........hc.................sssllR.........................GAVhhlth.hLhus........cth.s......................lp.s.......llsuhhp.Ahp....ssst.h.Vsh.Ell.hslppLl......tchtpp.ltth.sWs...hll.slhpp.....................................lhpplpsh.pt.p........................................................lp.s.lpcllss.lEpLhpp..sphp.sspcchhpllpps.tcphP-ushh.ll.....hctpphpPscs.tWlpsl...phlhcpFa.pppp...psslRlpsLpsl...s................................................................................	0	46	76	129
+11698	PF11865	DUF3385		Domain of unknown function (DUF3385)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3188 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is typically between 160 to 172 amino acids in length.  This domain is found associated with Pfam:PF00454, Pfam:PF02260, Pfam:PF02985, Pfam:PF02259 and Pfam:PF08771.	27.60	27.60	27.60	30.90	27.50	26.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.31	32	388	2012-10-11 20:01:02	2009-06-18 15:09:47	3	34	278	0	259	390	7	159.30	37	7.12	CHANGED	VlpPYhcYPpLLslLhslL+sE.pp.hslRpEsl+llGlLGALDPa+a+....plppstp........s......tppss.ssshhLhh.uhts......ss--aassVsl.psLhp..ILpDsSLspa+s.sllpuI.......hpIF..ps.hulcC.lsaLspllPshlpslR.ssss.shhEh.happLupLlslV+	............................VlpPYhcYPpLLslLlshLKoE..ps..tslR+Esl+lLGlLGALDPYKa+........lpppts.......................................................stp..t..tspss..s.ss..hL...l...u.h.s.....................st-EaYPsV..sI.ssLhc..IL+DsSLupaHs.tV...lpAI.......hhIF...+o.LGl+...C..VsaLspllPshlsVlR....ssss.....shhEh.hFpQLuhLlslV+..................................	0	97	151	223
+11699	PF11866	DUF3386		Protein of unknown function (DUF3386)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3390 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 220 amino acids in length.	25.00	25.00	30.80	30.60	24.70	21.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.15	0.70	-5.14	27	98	2009-06-18 14:28:42	2009-06-18 15:28:42	3	3	89	0	35	100	142	208.80	36	90.83	CHANGED	hssssssc-lFRsAYENRYTWDssFsGYpucshap....ps-cphpGphclu.sDLKspVpGI-Dpclt+ultuQLaEVsIHRVRRoFEpsHGcNoFsh.GcsspsG.lEl.lVuGKutGD+Y+l+sshlshVaR+IHGsllTIpThsspDTGpG.YLS+pYsS.YtDPpTG-tpuu+spFcDpat.l....ushWlLspR.sIcs.cspuppss....pp.......FpFss..........lphL	...h.hpphsAc-lFRsAYENRYTW.DtsFPGYpAclthp....pssphapGphpls..sD..hcscVp...sl-D..EclpculpsQLh-lslHRlRRsFE.psHG...cNs.Fsh..GcscpsG.lEl..lV.uGc..u.GspY+l+ssplshVpR+lcusslTIpTtssh-TGpG.YLS+pYsuhapDPpTs-h+s.....s+ppFcDpatpl....GsYalLsp.R.sIcs.pspupp.h....pp.......FtFpslphL..............	0	9	24	33
+11700	PF11867	DUF3387		Domain of unknown function (DUF3387)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3465 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria and archaea. This presumed domain is typically between 255 to 340 amino acids in length. This domain is found associated with Pfam:PF04851, Pfam:PF04313.	26.80	26.80	27.50	27.10	26.40	26.70	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.89	0.70	-5.48	52	900	2009-06-18 14:30:44	2009-06-18 15:30:44	3	11	772	0	213	818	195	283.60	26	33.78	CHANGED	osutG+GcsslDtpcAl.slhhEKh-ll+shh......+GFDYpsahsuss..pplphlssAhsalL..............u......c..........s..uK+RFhcsVhsLoKAauLsssp-E.Atsl+-EluFFpAl+utLhKhssssp..t..ssp-...hphsl+QllspAlso-t.VlDIFssuGlc+P-ISlLSD-FLt-V+phc.cKNLAlElLcKLLs--I+sRp+sNlVps+pFoEhLcpslp+YpN+uI...........soApVI-ELIphAK-hppstpRu-cLGLop-ElAFYDALAs.N-SAlc.hG--pL+pIAtELspplRpssol.DWs..tREolRA+lRlhVKRlLR+YsYPP.DhpppAscpVLcQA.Eh...lu....ppas	...................................................................................................................................................h...h.pth.ph.ht..thh.........thsh..t......h.......t............t.h...thh.......t...s.phlh.........................t..........p..hc...ppFht.shthtpuhsls...................s............p...t.......tt.......h.pp-.l.ta...httl+shl.h+h......ttst...........s.....tp............hpttl....ppllspul..h.........u.p..t....l........p.....l........h.t....h..........t............p.....l..sl..h.s............p.c.F..l.t.c....l.pphp.....pps..hthph..Lc+h..lppplp.hhcpN.sptppap-hlpphlpcYpspt..l.....................pstphlpc.Llp.h...u.p.chp.p.t.t.p.p...s...p...p.h..G..L....s..t..-.E...h..AFY....-.hLsp...s.............c..sh.....h......p...h...s..........c..........c..........p...L...p..t...l...Ac-ls..ptl....+...p...s...h..s..l...D.Wp....p+-ss+A+h.R.hhl++..l....L+...+...a...t..Y..P..P.....-h......t..ctAhptVlpQAE.ht....t................................................................................................................	0	79	150	185
+11701	PF11868	DUF3388		Protein of unknown function (DUF3388)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3650 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 261 to 275 amino acids in length. This protein is found associated with Pfam:PF01842.	25.00	25.00	39.00	38.20	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.15	0.71	-5.16	8	391	2009-06-18 14:32:00	2009-06-18 15:32:00	3	2	390	0	45	120	0	192.80	73	72.19	CHANGED	VTKhRpPKLRDRLAlRHGRYIpRDADDKKTFRFVR-ELGLLVDFMAELFK+-GHKLIGIRGMPRVGKTESIVAASVCANKRWLFlSSTLIKQTVRSQLhcDEaSc-sIFIIDGIVSsRRusE+HhQLlRElMRLPusKVVEHPDlFVcpSEYThDDFDYIIELRssssEEIpY-hsEcsphtstssF.......uuFsF	...lTKL+pPcLRDRLAVRHGRYI-pDAcDKKTFRFpR--LGLLVDFLAELFKcEGHKLIGIRGMPRVGKTESIVAuSVCApKRWLFlSSTLIKQTVRSpLIcsEYs.sN.pVaIIDGhVosRcuN.+H.pLVpElMsLPohKVVEHPDlFVcsSphTh-DFDYIIELRcs.spEIpYEchcc.p.ht.opNNh.....s..........	0	14	28	37
+11702	PF11869	DUF3389		Protein of unknown function (DUF3389)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3739 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.	25.00	25.00	28.30	48.20	21.40	17.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.39	0.72	-4.09	17	137	2009-06-18 15:30:29	2009-06-18 16:30:29	3	1	136	0	26	81	4	69.60	55	99.37	CHANGED	MllsFSpGKlIso.pElhlRLssss.VsLQApsDslpLlu.sAsVllAsGuss+WSlKLDs-pQLpslupplGlslt	.........................MVIpFStGKlIsT.+ElVlRLsttt.lTLQAps-sIpLhu.GANVhlANGSEsKWSlKLDsE-QLpsIAppLGhDl......	0	2	7	18
+11703	PF11870	DUF3390		Domain of unknown function (DUF3390)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3832 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 90 amino acids in length. This domain is found associated with Pfam:PF02589.	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.22	0.72	-4.06	34	1109	2009-06-18 15:32:31	2009-06-18 16:32:31	3	7	1031	0	194	665	49	93.20	28	19.55	CHANGED	+LRpEshpps....tp..hpupsuptsphEphsaKsauhhsosPslY+.........hhsahssch...pshhP..s.ltsWTpsRshPcPAtcoL+-lh+t+tptp	.................................................shs.ttpuhpsts..EphAhKhFuhssopPs..la+huhth.................sthhsa..h..h...ssh.........tsh..sP......u..l...psWscsR-hPpsstco..FRpWa+c+tt..p......	0	51	126	163
+11704	PF11871	DUF3391		Domain of unknown function (DUF3391)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2190 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is typically between 122 to 139 amino acids in length. This domain is found associated with Pfam:PF01966.	27.80	27.80	28.70	28.00	27.60	27.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.31	0.71	-3.93	121	695	2009-06-18 15:45:03	2009-06-18 16:45:03	3	4	415	0	262	656	53	130.20	21	32.31	CHANGED	hhh...........+IslscLplGMaVptls..sWp..scsal.h......sphhlcspppIpp.lpppGlppVhlDsp+u......s.s.......................thptssss....ph...thttpph.............t..............hshppch.......ppAp......phhscupshhpplhschptG.pslshpsspt	.......................h+lslspLp.GMalpths..sWh..c+PFh.h.......ssFhlcsppplpt....l+p.Glp.pValD..ss+u....t.shs............................................s.ttt.sts...th.......t.tspth....................................................t.sshcccl...........ppup......phhpcutshhpshhsch+.s..thshtth..........................................................................................................	0	57	149	212
+11705	PF11872	DUF3392		Protein of unknown function (DUF3392)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2322 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.	25.00	25.00	63.30	63.20	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.19	0.72	-4.07	21	196	2009-09-10 17:12:07	2009-06-18 17:11:28	3	1	195	0	46	106	9	104.90	45	96.17	CHANGED	-hllsLlsplupalpPaLs-IulAlVAClLVlaGs-IN+hL+phlushsFllRThsFlLlsAFGYGllllaloPhlspsLtplsshaLsslllssFllIGhhApRp	.....lhshLAshuphltPaLSEISlALVAChLVlhGu-INuaL++tLpshpFllRTlsFlllsAFGYGLllVhAoPaluRsLuphssthhhslllssFllIGlhApRp..	0	8	16	33
+11706	PF11873	DUF3393		Domain of unknown function (DUF3393)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2361 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is typically between 188 to 206 amino acids in length. This domain is found associated with Pfam:PF01464.	31.20	31.20	34.20	31.70	28.70	28.60	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.26	0.71	-4.81	30	814	2009-06-18 16:15:39	2009-06-18 17:15:39	3	2	791	0	95	402	21	192.00	64	53.05	CHANGED	pKhlhlhhhlhl.....LsuCo............................tp.spptsshsssh............h.+Dppu....lctLhsphu.....pplcchWGpcEhhhAu++cYVKYoDsYpoRuclsF-cGtIhlETlus..pP...pppL+pAIlpTLLhssDPstlDLaS..s.pclslsu+PFLhGQVlDpcGcsIpapWRAsRaAcYLlpN+Lps+plpptp.laaVpIsMVssHhchRut+	.........................................................................KKhLALAlIAPL.....LlSCS........................................ooKKG..ssYNEAa......................VKDTNG.........FDILMGQFA.....HNIENIWGh+EV.lI.AGPKDYVKYTDQYQTRS..HINFD-GTITIETIAG..T-P.......sAHLRcAII+TL.LMG.DDPuSVDLYS..DVcDIpI..SKEPFLYGQVlDNTGQPIRWEuRAosFADYLLpN+LKoR..os....G....L+....l....I..YSVTIsMVPNHLDKRAHK......................................................................	0	13	40	70
+11707	PF11874	DUF3394		Domain of unknown function (DUF3394)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2758 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 190 amino acids in length. This domain is found associated with Pfam:PF06808.	28.20	28.20	28.50	28.50	28.10	27.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.02	0.71	-4.74	44	269	2009-06-18 16:26:19	2009-06-18 17:26:19	3	4	259	0	78	243	664	173.50	39	20.60	CHANGED	culllhlsAslAMLlFuAATQGaFls+o+haEoslLLLlAFoLFRPGFWhDhlhPsapphsssclhphhtphssGpslRlplpG.sh..pGc.hppTlhLsls........-su.sutpRLpsh.GLpLhp..........-ssphllDtltFGSs.A-psGl-FD.a.......pIstlphs.s-RPsKEhhaIPALLLLullshhQ..RRRtpps	.....phhLshloullAMLlFoAATQGWalT+s+aWEslhLLllsFohFRPGFWhDhlhPsh..hhsuscltphspphssGpslphhVsG.sh..pG-.h.p+...TVtLPht............-tu...sup..-...Rl.....t.uh.GLt.Lh..p..........ps.s+.h.ll-hV.pFGSP.ActuGl-FDa............cItpVhhs.s-RP.KEa.halPAlLLhhllsh.Q+RRhpp.s....................	0	24	51	66
+11708	PF11875	DUF3395		Domain of unknown function (DUF3395)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2767 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 147 to 176 amino acids in length. This domain is found associated with Pfam:PF00226.	27.10	27.10	27.60	28.30	22.80	23.10	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.84	0.71	-4.58	28	266	2009-06-18 16:27:41	2009-06-18 17:27:41	3	6	206	0	180	262	3	142.70	35	24.75	CHANGED	Phpcppppcthtcp+cppcpplspc+pcAppslplhpstsp+phppEpp+sGLlIhpAhYGphss..................................................thstppshpst...........slDVTlslQshV.ccSpLhlsp.....................ssKupLhGFaDP..........................s....spcKhL+IpYpa+sphHplhlsDs-slplP	......................................Ph.ptppcpphtcp+cpttppltp.++.pEAppAlpLMpps..spRhhptE..c.p+...tGLlIlpAhYGphss................................................................................................ptptppps....................pslDVTlPLQsLV.......cc..S......p......LhLsc........................................ssKus..L.GFaDP...................................................ss...G-pKpL+.VhYpF+uhhHpVhstDp-sltlP..................................................	0	63	99	146
+11709	PF11876	DUF3396		Protein of unknown function (DUF3396)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2995 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 302 to 382 amino acids in length.	25.00	25.00	26.80	26.40	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.41	0.70	-5.21	23	202	2009-06-18 16:28:56	2009-06-18 17:28:56	3	1	102	0	71	241	2	193.20	27	58.49	CHANGED	utYpFphh..........uhpp..hp.thspc.ulsslsFolPhtalpp.s.Psh..aptLhhphAppLssppGaAGhuhsl.shshctspspEahhupRa.sGlDVssstps.....tshpls..sc.......................IKsVsWLThlssshlcpLG...GspuL+stL..s.s.hslpshss.GllIpAGsh.PphGsspcss.....hPssYlhlN+sL+slhs..pphstLphtshsupu.h..sptusptWL+RF	.....................................a.h.hh..........s.pt.....t.stp.shssLphslPhtalpp..t..ssh..atthh...hthsppLps.pGauGh...uhs...l...sts..hp......p.....t.s...h...E..ahlu.p...+a.sGLpVs.sssth.............tshphh...sp.......................I+slsWlThlupthlppLG................Ghstl+ttL...s.s.hshpsa..........ss.GllIpAGth.PphGshsts.......hP.sYhhlNphL+PlRh..pph..ttLp.h..hsuts.h...sptsottWhtRF...........................	0	8	24	48
+11710	PF11877	DUF3397		Protein of unknown function (DUF3397)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3446 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 114 to 128 amino acids in length.	25.00	25.00	26.60	26.40	23.20	22.60	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.81	0.71	-4.09	22	609	2009-06-18 16:30:47	2009-06-18 17:30:47	3	1	607	0	69	290	1	112.90	36	95.07	CHANGED	hhhhshhhllls.lhshllsth...hplp+p....th.ph...sDluh.hhhlulhhl.tphaspShlshlllhl.llulhlslhhhhpppphha++hhKhaWRhsFLlshhhYlsL....llhshhh	..............hlh.hlhllLshllshIl.sph.....FpLp+h.....th.pF....sDLAhPhLlhthalloscsascsh.L..Ph.l.hL..sl.lLuI.l.ls.h.ahhhKccs.....h...hYs+FhKhFWRhsFLLThlhYlth....llhhhh.h...........	0	18	39	50
+11711	PF11878	DUF3398		Domain of unknown function (DUF3398)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3712 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 100 amino acids in length.	28.30	28.30	28.50	28.90	28.10	28.20	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.29	0.72	-4.16	20	472	2009-06-18 16:32:43	2009-06-18 17:32:43	3	9	84	0	212	372	0	93.00	36	5.31	CHANGED	hp+tsplpssPLR-LlcFPsDDlplphlsRctRTlpssVPc-s.pph..sha............V+-ClcsYsp-WplVph+Y.cphSushp.hhsppphchp+.....LspQsFE	...............h.p+.splps.ssLR-Ll.FP.DDlplshlsRctRTlpsoVP--u..pch..sha.............................................................V+-..Cl+oYspDWtlVshKY..cph.Su.s.a.p..p......h.s.scphchpK.....LPppsFE.................................	0	39	55	115
+11712	PF11879	DUF3399		Domain of unknown function (DUF3399)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3857 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 100 amino acids in length.  This domain is found associated with Pfam:PF02214, Pfam:PF00520.	25.00	25.00	30.60	30.00	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.69	0.72	-3.80	11	201	2009-09-10 20:21:33	2009-06-18 17:34:18	3	7	78	0	106	192	0	103.70	45	19.28	CHANGED	LppK+NG.LsptLp.sustt-p.hhsKspShhEpQHHHLLHCLEKTT...................sH.EFlDEph.a-pshhEsuhtshs.S+SsSlSSp.....ulosoCCoRRsK+..shpLsNushsu	........................lppK+NG.h.p.uLp.s.....Gs....t--p..hhsK..s.pS.h...FEpQHHHLLHCLEKTT...........................sH.EFlDEph.FppsshcsuhtshsoSRSsSlSS...ps.........u.lsooCCuRRtK+..sh+lsNushs......................................	0	18	27	59
+11713	PF11880	DUF3400		Domain of unknown function (DUF3400)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3996 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 50 amino acids in length.  This domain is found associated with Pfam:PF02754, Pfam:PF02913, Pfam:PF01565.	25.00	25.00	33.90	32.40	23.40	22.10	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-8.31	0.72	-4.74	20	251	2009-06-18 16:36:00	2009-06-18 17:36:00	3	7	245	0	83	236	35	45.40	65	3.53	CHANGED	SRYs-Ds.s..l-ADYIVVEMA+HlLGENWhs-YVt+ANsGGIERVLl	.SRYs-Ds.s...lpADYIVVEMA+HlLGENWhs-YVp+ANsGGIERVLl..	0	15	52	69
+11714	PF11881	DUF3401		Domain of unknown function (DUF3401)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2478 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 231 to 250 amino acids in length. This domain is found associated with Pfam:PF02145, Pfam:PF00595.	25.00	25.00	40.40	34.60	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.96	0.70	-4.97	11	199	2009-06-18 16:41:43	2009-06-18 17:41:43	3	5	38	0	83	145	0	232.40	45	15.83	CHANGED	K+hpusussh.upsRhRAoLRDlc.SPptstKSol--DlKKLIh..DSPsstpp+ch................s..sssSs.RRSLaRTLSDESlh.SGpRpsSauoScu.hL-QuLPsDlLFo......sSTLP..........Pp..shPhpp.uht.uhpsl+u-hSASDsSLsDh.-p.+th.h.DPGLMPLPDTAus..L-WSpLVDAA+AFE...................sQRss.Fsohs-s.ppupshpsstp......spphsspsspsh........hsuccSPss.....................LsGKVsQLEshLK	............................Kphpossppl.upspLRASlRDl+.SP+ts.hKSTlE-DLKKLIh.hDSPssEpp+ch................................s..ss.Ss.RRuLpRTLSDESlh.SupR-sSFuSstS.hL-puLPsDlLFo......sSThP...............Pp...shPhpp.u.ht...Ght..sl+...u-hSAS-sS.LsDh.-p.+....h.DPGLMPLPDTAus..L-WSsLVDAAKAaE.........................................................sQRus.h.su.s-s..pps.sh..tssps............ptssss.+sh..........ssu.c-u.Pss.....................LsuKVsQLEshL+...............................................	0	3	11	31
+11715	PF11882	DUF3402		Domain of unknown function (DUF3402)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2702 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 350 to 473 amino acids in length. This domain is found associated with Pfam:PF07923.	25.00	25.00	26.30	26.90	23.10	24.90	hmmbuild  -o /dev/null HMM SEED	409	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.35	0.70	-5.42	22	336	2009-06-18 16:43:09	2009-06-18 17:43:09	3	9	231	0	228	328	0	384.80	36	46.72	CHANGED	PhulhEAsclaus+l+hohuh+QLWcER...-cFh+h-RG..........tsspp..s.s.-lpp.h.p.p.p.hhphst.p...pt..........ssppplp......hlptVEshYppsLspLpohlhVLL+hllushs.........................sphptts......shhsss.scp.s.t...................sh..pl-hhRt+EIssKAlSulLlLLLKWFKlSHlLKFEYhoQLLhDusalsLlLKhFsh.............................pshsphlss+sch...phsFaphC...........hh...........................................................................hs-.lsphuhssst.sptsht...a.shRNF.FSsINhL+IhpK.lsKpKspRhhhLspaKSSsILK+hL.KlspspLphYsLKlhKpQlPYpGRKWRp..uNMclIouIYLpsR.cL+D-WLsGsDl-u-hp-uhspEpALRuLlcaaNhRRY................................c.M........................sht...thtthhp....................................................................................Ept-hFhpph	....................................................................................tu..ass+l.+.pchpp.L.ppR...p+FhtaphG..........................................tssps..ssh..s...psl..p.cthpphppch.hhshschphp..pcth.................................................ttpc-lp........sssEhhYps....hLPsLsphhIsLLKllL..usss............................................................sspscspu................hNhhscshspphs...psh.......................psh..p.tlDlsRpKEIhsKAlSulLLLLLKaFKlsH........lhpFEYhuQhLl.uNhlPLlLKhFs..............................................................................Qsl.phlssKssh.........s.hsa.ptshtp.....................................................................................................hsE.lst.uh.sssssp........a.saRNh.FSsIN.hLRILpK.loKhKppRs.h................h.....LV.aKSusILK+sL.KV................p.shhpLYlLKLlK.Qs.YhGRpW..Rp....SNM+shoAIY.psRhcLpD.DWh...hG..........s...D..l.....Ducs...-h.s.p.EpsLRu.lcha....N.RRY.......................................................sc.h..................................................................shp......thpthht........................................................................p.......................................................................................................................	0	68	106	173
+11716	PF11883	DUF3403		Domain of unknown function (DUF3403)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2739 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes.  This presumed domain is about 50 amino acids in length.  This domain is found associated with Pfam:PF00069, Pfam:PF08276, Pfam:PF00954, Pfam:PF01453.	27.30	27.30	27.40	27.30	27.20	27.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.48	0.72	-3.69	31	401	2009-09-14 08:07:09	2009-06-18 17:45:01	3	35	35	0	184	445	0	45.40	38	7.07	CHANGED	SEsssIPQPK.PGaCltRush-s-sSSSpph..s-ohTVNQhTsSVIDAR	.......o-ssplPpPKpPGaslt+s..sh-s.....s..sSSopp.....-shoVNphTholl-uR.........	0	18	139	156
+11717	PF11884	DUF3404		Domain of unknown function (DUF3404)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2879 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 260 amino acids in length. This domain is found associated with Pfam:PF02518, Pfam:PF00512.	25.00	25.00	27.80	26.90	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.61	0.70	-5.50	10	181	2009-06-18 16:46:17	2009-06-18 17:46:17	3	3	113	0	17	103	2	254.20	48	54.22	CHANGED	hlhus.AaAD..SLPE..RIDsFpphFshpsAspoYDlRplQusYPTpLLoPsShLPQTucYPLK-IQpLYplApTCpGphPL..SPLlTEPLVFTRAlC+GopLsscWFuRSGLIHPGGGSYAsRYlpKaP-pcppLtpaMHI+ERslAspspLLu+L.QpMss-uIsALluGushFls.s-ELWLR+GstYalaspssWpssssstsLshslhopsssCalppGNICWcl.ED+SclLpauhIhLllANlhLllG...WulYRWNsKRcEM+	.........................hlss.sphD..sLPE..RhslFhphh..ppuos.hs.polp.pYPptLLoscShhPphopYshpDIptLaphAppC......pu+hPh..SPhls-sl.FphALC+t.osLuscWFsRsuhlHPuGGoYAt.RYl.E+aPsp.tsL....hsahHlpcps.Aucs.....plL.ap.L.QphupsulsALluGhphalu.ss-LWLppss.......taalhspppWps.ssphslohs.hp.Ac.psChhphuNlCas...cspSclL......hhShllL.lhh.slhLlhG...hSlYphppc+pEhR...........	0	4	6	13
+11718	PF11885	DUF3405		Protein of unknown function (DUF3405)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3057 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 636 to 810 amino acids in length.	25.00	25.00	27.20	25.40	24.80	23.70	hmmbuild  -o /dev/null HMM SEED	496	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.97	0.70	-6.26	25	217	2009-09-11 13:24:11	2009-06-18 17:47:24	3	5	82	0	180	215	1	433.40	36	68.33	CHANGED	lCF-RauRaGPY.....GhG..ht...................................................ps-+puhppsht......................pVD..W.cpV...........sWuphQpcChp+NppR.Fts..................pssphpshshsp...ttt.t.....tt...........................phsRTAlllRsapsapaT-cDlhhlRuLIsELSLpS.GGEYsValLlcVKD.sslt..Iaus..--sYp+sLc-s.lPtEF+uMssLWsEpphphhYPs.lpc.h..................+tsaputh.hPlQhFuhpaPEaDaaWpWEhDsRaTGHaY+hhs+lspaA+pQPRKuLWERNuRFYlPuhHGsa-.sFpphVcht...............................................................tu.ccslWGP.......p....tshss.PPss....cD..cYcWGVGEEADLIshsPlFDPp.sTsWlhcs-lpGY.stp...s.tsPRRAulITtuRlSR+LLtsMHcEshtt+HthhSEMaPsTsALa........HG..............hKAVasPHPVahD+pWssctlsphaN...uG.sssoGGs+sSsau.s+Epsh........+..GsoWaYsusaussLacRWLGa.chss....sGGc...t........hc.................stcGRhCLPsMLLHPlKc	.......................................................................Ca-RhsRhGPY.....Ghu.................................................................ppts.tt.htt..............................lc..a..ppl...........sWuphQppChp.tN.ttRFt...............................................t.t..h..ht.......................t..............................................................................................sRoAlllRsassh...pasppshh.lRuhIsELSLtS.GGEYpVahLlcV+-psh....I.asD..pcsYpphlpcs.lPtEFpuhshLWs-tththhYst.l.c..........................+slaputa.hshQhFu..hpHPEaDahWpWEhDhRaoG+aYchhs+ls.pau+pQPR+tLWERstRaYlPshH.Gsa-.sFpphlc...................................................................s..ppslWGP....................p...........t..shPPs..s.....pD.....papWGVGE-ADhIshsPlacP...sosWlhps.clhGY.ptp.....................sPRRssIlTtoRhSR+LL.sMHpEshhtpH.hhoEMhPsosALh........HG......................hKAVasPHPlahD......RpW.ss..p...htphaN.............sG.su...touu.tsSsau.tp....Epph..........p..GhoWaYputhsspLappWhGh.p.ss...tGGp.t........hE..............................ttpGRhCLPshLlHPlKp.............................	0	44	95	152
+11719	PF11886	DUF3406		Domain of unknown function (DUF3406)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3286 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 270 amino acids in length. This domain is found associated with Pfam:PF04548.	25.00	25.00	25.60	25.10	20.30	19.70	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.23	0.70	-5.55	9	103	2009-06-18 16:48:28	2009-06-18 17:48:28	3	3	27	0	72	111	2	243.70	45	26.62	CHANGED	sstPssVuVPhPDMsLPsSFDSDs.PsHRYRhL-ssspaLsRPVL-sHGWDHDsGaDGlslE+thslppphPu..osssQVoKDKK-sslph-uuhShK.HsEstoohsGaDlQolGKcLAYolRGET+FKNh++NKTsuGlSsTaLGDslusGlKlEDplhlGKplpLlsSsGsMpupGDsAYGuslEApLRcKDYPlupphooLGLSlhcW+uDLAlGsNLQSQh.lGRsSphss+hsLNN+toGQlolRssoSEplpIALlullPlhtulhpphps	.............s...ttssVPhPDhsLPsSFDSDs.PsaRYRhL-s.ssphLsRPVL-scGWDHDsGaDGlslEpshsltsp......hPu..uhssQloKDK+-hslph-susuhK.as-stoohsGhDlQo.lG.+pLuYslRuET+F+Nh++NpTsuGlShThlGcphssGhKlEDplhlGKRltLVsssGshpup....GDsAY..GushEspL+t+DYPlsps.uoLuhSlhpW+.t-huluuNLQSQhplGRsoph........ss+ssLNN+tsGQlol+ssoSEplQIALlullPlhttlhpph.........	0	13	41	56
+11720	PF11887	DUF3407		Protein of unknown function (DUF3407)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3559 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 360 to 454 amino acids in length. This protein is found associated with Pfam:PF02470.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.60	0.70	-5.11	43	1339	2009-06-18 16:50:23	2009-06-18 17:50:23	3	3	164	0	385	1189	0	215.70	19	52.68	CHANGED	psLsslLcplDPsKLNuTLoAlApALcGpG-clGpulsshNslLtplNPphPslpcDlpsLsslu-sYu-AAsDllssLcsuoTTSpTlssppssLDulLlussGhusoGs-lLssspssLlcusssLtPTspLLscYSPthsChlpGh.tthssthtcshG.G.NGhultlsss...............................................hlhGss.PYpYP-sLPplsA.+G.G.tt.PuCh...sLPc..sscs.....a......Ps.hLV.ssTGh.........ssssa.p..............s.sl..................GpPhhtpal................h.Gst.sGsss.........................................................................ssP	.........................................................p......lsthlssh....upul.s...G.p.G.spls.psl.......sphsplhspLs..s...ph..s.s..lt..p..s...lcsLsslssshucsssslhphlsshs.s.sspslssppspLsshLt.......shsshuss.s.s......shlspspspLhp....sls..pL.ss.sh.phLsphs.s.pl.p...h...lt.h.......h................................................................................................................................................................................................................................................................................................................................................h................................................................................................................................................................................	0	62	221	326
+11721	PF11888	DUF3408		Protein of unknown function (DUF3408)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3594 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 128 to 160 amino acids in length.	50.10	50.10	51.50	51.20	49.70	49.70	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.72	0.71	-4.24	32	653	2009-06-18 16:51:41	2009-06-18 17:51:41	3	1	126	0	52	483	10	133.40	20	94.25	CHANGED	sppplccctlhchhttts............................spsssptsssscpsppppssts......................t.ptpppcts.p-YcppFL.pssplssRps..lYlsc-l+-+ls+llpsluttcholuual-NlLpcHhcpap-pIpphhppphp...........a	.....................................................................................t.................................................tt.tt.....t.p...tp.tttt.................................tp.tttpp+tphp-YcptFL..p..ssc..hp..sRps..lYlsp-h+c+lppllpslGp..pcholuual-NlLccHl-pap-cIpphhtpp....ph......	0	20	47	52
+11722	PF11889	DUF3409		Domain of unknown function (DUF3409)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3824 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in viruses.  This presumed domain is about 60 amino acids in length.  This domain is found associated with Pfam:PF00271, Pfam:PF05550, Pfam:PF05578.	32.40	32.40	56.90	39.50	28.30	27.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.84	0.72	-4.27	8	239	2009-06-18 16:53:22	2009-06-18 17:53:22	3	16	46	0	0	263	0	55.50	75	2.50	CHANGED	Dcsus+p+cKKPDRl+KGsMKIsPKEoEKDSKTKPPDATIVVEGVKYQVKKKGKV+	........-cGAsspKppKPDRlcKG+MKIsPKEsEKDSKTKPPDATIVVEGVKYQVKKKGKVK........	0	0	0	0
+11723	PF11890	DUF3410		Domain of unknown function (DUF3410)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1956 (release 23.0)	Family	This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 90 amino acids in length. This domain is found associated with Pfam:PF02826, Pfam:PF00389. This domain has a conserved RRE sequence motif.	27.20	27.20	27.40	27.40	27.10	26.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.84	0.72	-4.33	64	939	2009-06-19 10:12:49	2009-06-19 11:12:49	3	4	934	10	136	570	33	80.40	53	21.55	CHANGED	slLPss.lsplslstph-..ps.sLtpLs+hlYDlRcDDuhh...R.csh............tpssuFDtLRKpY.....RREaSuLpl.t......spspss..hphLptLG	.....................t.LLPsPphu+lsLc..u..sLD....ps.TLK+LsHLVYDVRRDDAsL...R+su...................uhPGpFD+LRKNYh...-RRE.WSSLhV.h......s-ctss....AulLscLG.................	0	28	58	100
+11724	PF11891	DUF3411		Domain of unknown function (DUF3411)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1986 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 168 to 186 amino acids in length. This domain has a conserved RYQ sequence motif.	25.00	25.00	30.40	26.00	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.01	0.71	-4.58	14	218	2009-06-19 10:19:12	2009-06-19 11:19:12	3	6	31	0	146	212	4	165.50	34	39.91	CHANGED	sRhLADPpFLaKluhEpslshsssshuEhppRt-p.Fh..sEh-hshsshlsuslsshhlValhAPshuhsssus..su................thpthhtslP.sNsFptuh.shppaoltpRluolhhKGsphusVGhsuGllusuluNsLhst++thp.....pp......sspsPPlhpouhsaGsFhGlSuNlRYQllsGl..-	........................tRhLADPp.FlaKlshEpslslsssshu-hppRtcp.Fh...pEhDhshssllhuslsshhlVaL.APshuhtssss.......................thtthhtshP..sshFptuh....shp.p..asltpRlushhh+GsphusVGhsuullGs..............uloNsLhsh+.+php.....ps.....................sspssPlhpsAhsausahulSuNlRYQllsGl.......................	0	38	100	128
+11725	PF11892	DUF3412		Domain of unknown function (DUF3412)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1106 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain is found associated with Pfam:PF03641.	25.00	25.00	32.00	58.30	22.50	20.80	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.63	0.71	-4.29	49	901	2009-06-19 10:27:43	2009-06-19 11:27:43	3	3	892	10	132	465	51	123.00	71	27.74	CHANGED	uMppV+paR+spuDAYpFNWSL+Ip.-FQhPF.PTHEsMAsLsLHhsQsscpLAANLRRAFSGIVAGNVKp-GI+tIEcaGPFcl+GDspLMcthDpLLpuFVpQpRMKLP.GotY.PCYcI.ss	.......MPhVKEpRR-TGDAYSFNWSh+IsPDLQhPFEPoHENMANLcLa.D.QPsElLAAsLRRAFSGIVAGNVKEsGIRAIEcaGPYKIpGDt-lM++MDcLLQuFVAQHRMKLP..GSAYlPCYEIs.s...............................	0	23	53	95
+11726	PF11893	DUF3413		Domain of unknown function (DUF3413)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1403 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 250 amino acids in length. This domain is found associated with Pfam:PF00884.	27.10	27.10	28.60	27.80	26.60	25.80	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.56	0.70	-5.50	39	977	2009-09-14 14:01:40	2009-06-19 11:32:37	3	2	864	0	128	567	33	247.20	52	42.40	CHANGED	Mlpptp..pa+-clSphlsWGHWFuhFNlllAhllGsRYl.hhssa........PsThlGhh...YhhlShlGHFoFLsFhhaLlhlFPLoalls.p+hhRslusllATlulslLllDT.laspashHLsshVacLlhsstp.spls....tpWthhal...shPl.Illlphhhupah...Wc+lcplp+p.+.hG+hluhhhhhsFluSHllaIWADAshY.pPIThQcssaPLSYPhTA+oFhcK.aGlLsppphppphptptpsps.........plpYPlpsLphs	..........................................................................MVsppp..pYRE+VSQhlSWGHWFALFNILLu....hllGSR.YL.FluDW...............Ps.TL..sG+lY.hl.S.hlGH.F.SFLVFAsYLLlLFPL.TFI...V....h.....Sp.....R...LhRF.LSsIlAT.AGhTLLLlDoEVFsRF+LHLNPlVWpLllNP-p.sEhu.....RDWQ..L..hFI....ulPl..IL.LlEh..lFAsWu...WQ.K..LRSLsR+.....+...auR..P..L..A..Ahhhlu...Fl..A..S...H.llYIWADAsaY.RPITMQRANLPLSYPMTAR+FLEK.HGL..LDuQ....EYpRRLhE..QGsP-Al.........ulpYPLspLca.p........................................	0	26	53	93
+11727	PF11894	DUF3414		Protein of unknown function (DUF3414)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1638 (release 23.0)	Family	This family of proteins are functionally uncharacterised. The family is found in eukaryotes and has a conserved LLG sequence motif.	26.40	26.40	27.00	26.90	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	1691	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.42	0.69	-14.40	0.69	-7.68	32	424	2009-09-11 06:03:47	2009-06-19 11:35:43	3	13	249	0	291	403	2	1089.40	19	83.73	CHANGED	hWss..hcpLapslp....hhsppp.psl..ppL..pLcpht.shhsLLcpPs+sspsRpplp..............pGtlphuctschplsp-hlppulhLuDtLsLcEltAs-Llh..supppp....th.uhshh.sAllhYaptRphlLssL+hlhptt.t....phs.....p-l.pchhphh..........................pahcphltshshlcphLshls-.ls..............tsplh..sphp...shs..cphchh+s..........hlhcp+chLuthLashspp...shhstsshhpllptLpp..l.......sshDtlhlthlsulltsh.............................................tss.pthshhsscphtpslpsclpspt........................Wth.shpuslhhhahshhtuhsptssstts...shshpccs-...phhppAlp.............sGuhcaLhthshcs........p..t.....thh..L.pt.s.................................................................sshh.....cp....................................hhhpphcshlpshI.sshs.hlpcL+scE--sths..st.p.s.s.s....................................................................shptcLEcFhlhluhhYpscP...-huhp.aWssp-..ssh...............................htFlpaAuchtssslh.ssahcMLsuLos.G.psAptsaphLppss...........tt.tsloWcphFpsLphYhpplp...........p..spspsl.hspss.psh.................stcphhhLsuaLpLlsplspp..s.pssR.tl.......hcpssap..ssllhsLhps..........slP.tL+As.....................................lhpsLuulh..........s+s.ptutplWptlDphhhtsshtsss.t.....................pshshptc............hpthpshtppaststuFlpLlpsLlpst.....t.......h.aPpsLGsu..........................hR...hsGlpPYlc....Flhsplhhc..spshtcsspphplt.ssLchhhpsLpsas.s.....hl.thspsts.......................sh.salt.p.Puhtlh.phLhspchhphlhsll..ppussplsphst.....p.ltpslhhuLpllshsLphQssahchlpsslp.........................................s.hhtshshhhp..ulssh.cth.hplsllshh.LahusspspluhsSl+ILpplupp.phs...............s+llslhsp...tspupcIptuFlppl-sp.sp.tt.................................................................tt..hplKhpILshL.ssLstts..pPslAHhLLGFcsp.tshhphs.p..shhsstpohL+ulLslLpphhsshps..........lshh.scLsphshpllhpLCp..sshoSthsLpalRs.....ssalhphlpp.Phls..hhhps...............................ussshhshLphRu....hlhphhulEl+s..huhpuphoptpplhshLls.............tphspsstsh..sp.........................................................lhslLDhlshsh....pphs..plshacs.hslp.shpp..........hpspt..uht.......lhs.hphLppllphchpshps.h..........p.sptp.l.....pEhptllpahsphNptpphttsphphLcSWsQLlplllssss...hsssp+pshIl-slphllsKlp...h-....shthu.plsplshsLhstlcpshh........................................ttphsshhss.............+La...lhpshlcuIhpss.us.pLRsshYshhhpYLptlhcsc...................................................hpcpshpllcshGccLl-slCsDAhsGcshsRhtAlhlL-sLlpl....s..............psshllphlspssaLplllcSl+pp-ttLps................hhs.sshhhtLh...........hacuplshLhRlApo..+pGAptLlpsslhphltpsphhshcP.Dlslc..hhcp.................................sss.hppaaplLhPsLplhssllhSh.................G.p.....scpshtpshpaLt...pppchlhull+csshht.........................................t..tthspht..pptl.plspthhllpshpp	...................................................................................................................h....l..p............t....h........p.....tp.+t.l..........................tt.h............................h.ls...t....sh.lus.hplsEh.shthhh...........tu.tt...........................s.....hh.a.a...tpt.hht.h..hh............................t....................................hh.thh.t.t.h.t.h..htt....ht...........................tt.........................t...................................................h.p....ls..lh...............h..hht.htt...................................................t..p.h.......h.hh......hh..h..............................................................h...h.............................................................h...h.h.h.h.h..h.....................t.............h...h........................tsh..h...............................................................................................................................................................hh...............ht..c...t................................................................................................................................ht........hh...h..ha..................p.s.....hh.......................................................t.Fh.............t...............h..shh.hltsls.........s..su..haphh..t...........................hs.atthht.h..a...hp.........................................................................................t..............................................................tp..hl.shhtlhttlh.............t...................................hhthht................h...lhut.....................................hh.hltth.................t..hW....l.c..................................................................................................................t..h..p...pth....shhthh..Lh...........................t...........................................t.......h..hhp.....hh..h.h...................h...t..p.h...........l....hphh.....l..h.....................................................................................................hh.ph..tt...hht.hh.h..........h...................................................sh.hh........hh.hp....h.t.h..........................................................................................h.....................h...shtl.h..h.........................................hh..h..........tl..sh..t.h.............................................................................................................................................ht..lhthh..sht........shshhLLthp..........................t.......................ohhpsll.h..h................................h.t..htlh..Lh...p...ss..hh..hp........thh...h.........................................................h......t.....hhphhsh.h...............t................hht.l......................................................................................................................................................h.phhp.h...........................h.....ht.....................................................................hp...h..h...hh.........................................p.....h....h..................hht.....sW.phh.h.h....................................hh.p.h...h..........................h.t....h..h...h............................................................................................................................................h....hh...h..h..................h....+...Y..h....hh.hh..................................................................................t....h..t..s.tthhphl.pDs...stt....ph..uh.hlt.l..h........t...................t.hh..h.p.shh..hhp..l........h...................................................................hh.s.h.hh.phst.....G...lht.thh...h...thht.......p...........t......................................................................................................ph.thh..hhplh...shh......................................................................................................................thh.hh..........h..hhp...................................................................................................t....................................................................................................................................	0	108	169	246
+11728	PF11895	DUF3415		Domain of unknown function (DUF3415)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1962 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length. This domain is found associated with Pfam:PF00141.	25.00	25.00	25.00	27.40	24.50	23.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.76	0.72	-4.11	35	127	2009-06-19 10:41:03	2009-06-19 11:41:03	3	2	39	55	5	183	0	77.90	45	21.94	CHANGED	sKhpssFpsshpKLulLGpstssLlDCS-VlPhPtPsssp...AaFPAGpohpDlE.tACsssPFPoLsoDPGPsToVsPVPss	....chtssFpsshtKLulLGpctssLlDC..SDVlPsPhshssp....uaFPAGhohsDlE.pAC..sp.oPFPoLsoDPGPtTolsPlPs.........	0	3	4	5
+11729	PF11896	DUF3416		Domain of unknown function (DUF3416)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_601 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 190 amino acids in length. This domain is found associated with Pfam:PF00128.	25.00	25.00	25.00	26.10	24.40	23.90	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.28	0.71	-4.34	88	711	2009-06-19 10:45:08	2009-06-19 11:45:08	3	10	684	18	232	658	95	186.60	32	25.33	CHANGED	stsRlsIEsVpPtlDsG+assKtlsG-.lsVpAclFpDGHDtluAsLhaR...........tsss......ps....Wp...................pssMp....h......uNDRWpupFsssp.Gpapapl-AWhD.auTW++slp+KlpAGt...-lsL-Lt-GutLlpcAst.pst...us.....ppttLpp.hsstLps..t..ssspp...luhhLssclsplhspts.R.shsTp.sp.hslhV-Rc	..............h..sRlsI-sVpP.l-s.....GpaPsKtllGE.lsVpAslat-GH-tluAsl.h.h+...............................sstt......pt....hp..............................phsMp..............sh......GsDpWpuphs..s.................cp.GpapapV-uWsDsauTW++shptKlsAG.............-lpl-LtEGstLlpcAsp.pss.....ts......................stp...sL....p....t...s.......sssLps..ts..........ssss+...luhhlssplsplht.pt....s.........R.phlop.utshs....lhV-R......................	0	62	140	191
+11730	PF11897	DUF3417		Protein of unknown function (DUF3417)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_724 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are typically between 145 to 860 amino acids in length. This protein is found associated with Pfam:PF00343. This protein has a conserved AYF sequence motif.	25.00	25.00	25.60	43.50	22.70	21.70	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.79	0.71	-4.15	79	640	2009-06-19 10:53:20	2009-06-19 11:53:20	3	8	576	0	243	588	45	116.40	36	14.10	CHANGED	shpphs........Vhsp.LP....cpLptL....p-LAhNLaWSWpscspsLFcplDspLWcpss+NPVthLtplsppcLcplupDtsalschctlhpchcpYhss..spWapp....sptt.spslAYFShEaGlp-oL	..............t.pphsVpspLPcpLptLs-LApN..LaWSWs.cspcLFpplD.spLW.c.p..ss+NPVtlLtpls.pRLcpLupDpsFlpchcplhschcsYhst....hWapp..................sstt..........ssslAYFShEaGlscsL.......	0	92	186	230
+11731	PF11898	DUF3418		Domain of unknown function (DUF3418)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1028 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with Pfam:PF07717, Pfam:PF00271, Pfam:PF04408.	25.00	25.00	25.60	25.50	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	586	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.63	0.70	-6.12	105	1852	2009-06-19 11:18:30	2009-06-19 12:18:30	3	22	1658	0	364	1658	366	534.70	42	45.93	CHANGED	K+pGpVhAhE+lTLYGLslVscRpVsYupIDP...ttuRElFIRcALVpG-h.....pT+t....sFhpcN......pcLlc-lEcLEcKuRRRDlLVD--sLasFYDpRlPsclssspsF-pWaKptp....cppPc...LLhhs+-pLhpcpustlostpaP-thph.uslcLsLoYpFEP......GpscDGVTlpVPlslLNQlsspth-WLVPGhhcE+lhALlKuLPKslRRphVPsP-aA...cuhltp..........h........pst..................ps.....sLhcuLscpLp+ho.Gl.....plst-sach..sp....LPsHLphsF+V...lD-cG.+.......h.............lupGRDLstL+pph.tspsppsls....psu.......................................................................s.s.....hcppulps.........W..s.FGsLPcphphc...p.u.G.....hpl.puYPALV....Dps...s.......uVulclF-sttcAppsp+tGlpRLlhLpls.s.l..KhLc+...pLPst............................scluLha............ssh.........Gps.ptLh-D.............hlssulcphhh....pt...s............................hs....psppsFpphhccsR........ucLsstspclsphlpplLsthppl...........p+pL+....u.phshsh.shuhs..............Dl....c...pQLspLlhtGFlspsshppLtchsRYL+AlphRL-KlstsP.sRDptphtclpsl.ppap.phhsp..h.t.up.h......sspl.pchRWMlEELRVSLFAQpLGTshPVSsKRlpcthppl	.........................................................................tpGuVhAhE+VTLYGLPlVstRtVsYupIDP.........s...huRElFIRpALVEG-a.................................pT.+a......sFapcNh+LhtElE-LEcKoRRRDlL..VDD-sLFpFYDpRI....sp-lhSu.........ppFDsWWKpsp............................cc..s....Pc......LLshp+s....Lh....p...c.s.A..p..p....lop.saPshWcp.....G..........s.....l......cLtLoYpFEP................Gs.s..s...DGVTVclPLslLNQl....p.t....psF-W.lPGLRcELlhuLIKSLPKslRRshVPAPsaAcAhLspl...................ssh..................ph.................sLlcsL.t+pL++hT...GV..............plst--W...p...h....sp....lPsHL+hsF+l...lD-...+s.+.........t............................................Ltcu+sLttL+ppL...ts...p.s...p.pols......tsA............................................................................................s..s...h-pp.s.l.ph........W..........s...F..GpLPc...p...hptc.....+.u..s.....hpl.puaPALV..........Dct.....c...............uVul+.lF-s.h......-t..ppuhhpG.l+RLlhLsls.sPl..KaLpc....pL..Pst.......................................................s+Lu.Lha.......sPa.................................Gpl..pLl-D.............slss.ulDpllt....tp..u.............................................................l.hsctsFttLt-c.lR........ucLsssshclu+plppILsthhsl................................................p++Lc.....u...phshsh....shuls.....................................................Dl...+...sQlssLlapGFlstsshpp..Lsch.RYLpAlphRL-KL.s.s..s....P...pRDpt...ph...hclcp...ltp...tap...phhsc........hs......stt..........stcl....p-lRWMlEELRVShFAQpL..GTshPlSsKRlhpshpp................................................	0	97	210	297
+11732	PF11899	DUF3419		Protein of unknown function (DUF3419)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1329 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 398 to 802 amino acids in length.	28.20	28.20	28.30	28.30	22.10	25.20	hmmbuild  -o /dev/null HMM SEED	380	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.08	0.70	-5.74	42	261	2009-06-19 11:23:06	2009-06-19 12:23:06	3	16	242	0	167	284	73	367.10	30	64.16	CHANGED	tshhcchashhap........shlYsphWE.........DPclDhpsLpls....sscpllsIsSuGsNhLuY..LstsPsclpAVDLNPspstLlcLKlAAh+sLs.apsFachFGcupp.......ps.pplhtppLsPpLssputpYWpp+......t+phs..hhs+GhYcpGhhGp.hlths+.hls+lhGl....plcpLhpApolcEQRphapp+.lpslh.s..pllphls.........sphhhhhuL....GlPssQhshl.................................................tsss..lhphltc+L-tlhssh.l.p-NYFha.slstpYst.........sshPsYLptcsappl.......+sss...-plclassslp-hLtphsssolsthlLhDu.DWhss..............................splss.hpp.lsRsspsGuRVlaRoAutp....................shh.tph............cphsapsctusthpst.......DRsshYuuhalhp..ct	.................................................................................h......hat.hhs.......thlYs.sWEDPclDhchLpls....ss-..pllsIsSuGsNhLsY..L.....psP.t+lcAVDLNPsQstLL-LKlAuhp..tLs.ap-ha..............chFG..cupp................s.shpplh.p.c.LuP..pLsspuhpYW.p+......hphhs......hhsculYcpGh.tp.h.lphs+..hlh+lh..G..l...........plcclhpup.olpEQRphapp+......lpshhhp.........hhlphhh............sphhhhhuL....GlP.sQhs.hl.........................................tsts..lhphlhspL-.lhpph.l.p-NYFhahsltG..cYsp..........pshP....sYLp.csatpl............+sss...-plclHsssls-h....lt....p.h.ssso....lshhllhDshDWhss....................................pphsp.hpt.ls+s...h.p.s.GuRVlhRoAuhp....................s..hh.tph............cp..hsapsctssthtst..............D...RsshYuuhalht..h...............................................	0	55	102	139
+11733	PF11900	DUF3420		Domain of unknown function (DUF3420)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1362 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00023.	25.00	25.00	25.90	25.50	22.90	24.80	hmmbuild  --amino -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.33	0.72	-3.86	26	221	2012-10-02 12:10:21	2009-06-19 12:25:11	3	20	51	0	50	251	0	49.20	42	12.95	CHANGED	DLDsloLEKpLP.-VlcpIcplRhp.t..........phsth.........sshp-K+l+RIH	..slDsloLEKpLP.EVlcKIctLRtpst...............sppsphsth......................sshc-K+IRRI+............	0	6	27	37
+11734	PF11901	DUF3421		Protein of unknown function (DUF3421)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1420 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 119 to 296 amino acids in length.	26.20	26.20	26.80	26.60	25.80	26.10	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.51	0.71	-4.37	49	531	2009-06-19 11:28:17	2009-06-19 12:28:17	3	18	87	0	352	549	3	104.40	31	58.48	CHANGED	huGpD.su..tslYVGRuh+pGshlPuKVlPs.+ttsalsaGGpEhttps..aEVLssssh........pWl.sssGslP.....sAl.sGpotp.GEsLYlGRupapGslssGK.lp.SHtshYIPasGtElp.hs	................................h.......t...haluR.s.h.ap.s.sh..lPu+lhsp.pt.hsahsa.s.utEht.....hpp..aElLsstth................pWl..sss.s.G.p.l.Ps.....................sAl.uG.....pss.s.....G..E.sLYlGRuh.a...p.G..slhsGK..lp.s...u.+.t...shalsasGtEht........................	0	119	159	290
+11735	PF11902	DUF3422		Protein of unknown function (DUF3422)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_513 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 426 to 444 amino acids in length.	25.00	25.00	38.00	37.70	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.31	0.70	-5.60	78	308	2009-06-19 11:40:50	2009-06-19 12:40:50	3	3	279	0	144	330	270	407.80	35	95.89	CHANGED	hpsHPL..RtsLtsElHARPa.hlssPtplsalAhh.......sspppss.-tspLssLtpphGhs.P.........sssus+aths.hGt...hpL+WEpHTEFsTYThht......sssspsFssss.....hshhP.....tsWhtphPG.....phlsusclplt...stssssptt.....h.ph.F.........................sspoLsuSpltsGsAhlhoDFRl.cscGasRhlV..hspslsstphGRlVQRLlEIETYRhhALLuLPhA+plssplsph-ppLuplspphsss...ssss-.............plLscLoplAAclEshsAposaRFuAopAYttlVppRlppLREp+ls.GhpThsEFhpRRhsPAM+TCpuspcRhcsLScRlsRAusLLRTRV-lphppQNppLLpSMs+RuclQLRLQpTVEGLSVsAISYYsluLluYlhculptht.....ls.l.s..hslhsul..ulPlVlhsVWhslRRl+++ht	....................................................................................................................h..tHPhRttLhsElHARPa.hlssPtplhalAhh.......................sstptst.cpstLtpLspphGhs..P.........ptsusHathp.hGt....hpL+WEpHTEFsTYTahts...........sssstsFssss.....hthhP...tsWhtphPG....phlsulclplh....stsssstth........ph.F.............................ssssLssSpV....t.....sG.....sA.........tlhoDF+l.cs-.....GasRhLl.....hs.pshsspphGRllQRLlEIETYRhhALLuLPhA+phsspLsph-pp..L...sp..lspphsss...ssssc.........................pLLscLopLAAclEshsApotaRFuAopAYtplVppRlppL+Ep+lt.GhpThs-FhpRRhsPAh+TCpuspcR.psLopRlsRAssLLRTRV-lphcpQN.......p.......pLLpSMscRAclQLRLQpTVEGLSVsAIoYYsluLhuYhhculpt....ht.......hs..l.s.splhsul..hlPlllhsVWhslRRl++ph.h.................................................	0	33	80	106
+11736	PF11903	DUF3423		Protein of unknown function (DUF3423)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_670 (release 23.0)	Domain	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 73 to 118 amino acids in length. This protein appears to be related to ribbon-helix-helix DNA-binding domains, suggesting these proteins may also bind DNA.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.31	0.72	-4.22	57	485	2012-10-02 18:44:02	2009-06-19 12:44:36	3	2	458	0	138	370	49	72.40	32	83.02	CHANGED	huhVKIsD-La-plRpsupshsRSIsuQhEaWh+lGhlsE..hsPsLsas.............................tltphhhpts........thphsph	....sll+Iu-pLa-slRttupshSRSlNuQhEaWh+lGhhsE...pPsLsap.............................tltphLhptt..............sh....................................................	0	33	66	106
+11737	PF11904	GPCR_chapero_1	DUF3424;	GPCR-chaperone	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_942 (release 23.0)	Domain	This domain, and the associated ANK family repeat Pfam:PF00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.	25.00	25.00	26.20	25.90	22.10	24.80	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.10	0.70	-5.28	39	534	2009-06-19 11:46:30	2009-06-19 12:46:30	3	13	131	0	299	479	1	286.90	32	59.12	CHANGED	RlDoTLhGF-.sh.......phpRucpSalF........cG-ssss...........plh.ls+cc+hlhsthhph............sttttcpplssh..............hpsslhsstlcspphshpcs................huW..Rp-+sEhl.s...sacu+lYsh.psV.l.h+pR..............................p-+Loc-pptphcs......................tpsshpshhs....................................-pph..........................................s.phpp.....shssss.sshs.c.phhsst...pht..spshG+...............sh.c.......sppppph+sslWloc-FPLp...............h.-pllPllDllA..sspthp+L+-h........................................loh...cLPs.GFPVKl...............................pIPlh.slpAtlTFspapthp..........................................................................schppshFpIPssYph	.......................................................................................................................RhDsTLhuFp.ph..........phpRGphSalF........pGpssss..............slh.lsHcp+hlhsthht............................sttp.ctplshh......................hsos.lhsstlcscp.l.sFp+s.....................huW...Rp-Ks.............EhV.s...sac.AK...........VYsh.s..sV.l.s+pR...........................................................p-HLocc-pt+.cu.........................hpshpphhs.......................................ppph...s...........................................................................................................t..hpt...........sh...ssss.s...slo.-..-Yhsst...........p.t...s.phG+............................h..th.........ppppp.pF+..AslWhsp-a..P.Ls..................................l.-plhPll-lhA...sstths+LR-F........................................lph...cLPs.GFPVKl...............................-....IPlh.slsAplTFtphphh.................................................................................t.p.p.FtlPtsY.........................................................................	0	80	134	207
+11738	PF11905	DUF3425		Domain of unknown function (DUF3425)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1128 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 120 to 143 amino acids in length.	27.10	27.10	27.80	27.50	26.40	24.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.10	0.71	-4.27	62	451	2009-06-19 12:01:03	2009-06-19 13:01:03	3	17	80	0	392	468	1	130.20	22	31.52	CHANGED	sthlu.a................h.sstts.tp.lPs.tLpPTt.Qh.....plPHtsh.lDhl.PaPphRDpLlpthpp...............h-ps.....chhp-hhss........................................hsttshtt.........................................psshlhh...tc...hc.psWEloptFhc+as..............hlhcut...phh.........ospa...Rt	..............................................................................................................s...t...tp..lP..tLpP.T..hQh.....................ph.PHtsa.lDhl.PaPphRDpllt....thst.....................hsps.....phhtshhss.........................................................................st..................................................................................................pss.hhh...tc..shchpsWclsttFhc+as..............hlhpst....................................................................	0	75	180	332
+11739	PF11906	DUF3426		Protein of unknown function (DUF3426)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1212 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 262 to 463 amino acids in length.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.78	0.71	-4.54	92	481	2009-06-19 14:23:17	2009-06-19 15:23:17	3	4	476	0	190	502	91	144.30	22	40.45	CHANGED	hsshhlhss.LhuQhsah..RsplsphhPphpshhpt..h...C..lGCpls...hslpslp..pt..shcphs.......sssslhlpuslhNpuchstshPtlcLslpDtpsp.lhp+sh..............P.tpalt.t........pst.....lsssps....hplpl......plp...ssss........pAssaclphh	..............................................................hshhhhhsLssQh.saht.ts..plstt.Pthp.shhpt...h........C...l.s..Cp......lss..hshptlp.h..ps...slcphs................ttsshlhlpuhlhNpushs.shPtlcLsltDtssphl.sp+hh.........................................tP.tpYltst.....s.......pst...................lsssps....hphtl.......plt...ssss........psssaplph....................................	0	50	121	156
+11740	PF11907	DUF3427		Domain of unknown function (DUF3427)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1236 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 243 to 275 amino acids in length. This domain is found associated with Pfam:PF04851, Pfam:PF00271.	27.70	27.70	27.80	28.50	27.10	27.40	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.81	0.70	-5.45	60	723	2009-09-11 10:09:40	2009-06-19 15:27:28	3	13	675	0	139	602	88	256.20	25	28.44	CHANGED	ph.lsppl....st.p.hth.hlt.hh.........................t.hthtph.p.lpp........t.........tphhphLphpaasspt......................hpht........hhplspphpphlpss...........thpp.lt-llphsl......pp.......t.......sslplapcYoRc-lhthls.hspspss.....htGhhhhps....pspslFlThpKs-c..hSsospYcDhhlspphF+WpSpsspshcSscspphlpppcp...Ghp...lhLFVRcps....uhsts.FhaLGps.phss......pp.................uppslshpacLc...pPlssslachhsp	....................................................................................................hhotphhsuh+.h-.hlLc.lh...........................................pp.p.hs..h.pp.h.p.h.pt...h.hspt.........shp...s...shphLshsFasss...........tph...........hlphpt........hhplspthpph..Lpsp.................tFpthlpDllchuh....pt........p..ttp.....ssLhLap+YoRc-hs+lhs...asps.tsus.........hhG.Yhhtpp.........phslFlTacKp-c..hssss.......pYcDpals..ppph+Who+ss+.slc.Spcsppllppctp...shp....lhlFV++pc.........sput..FaYLGps...phlp...ts..................tupssVshshpLc...pslpsclachh...................................	0	49	95	121
+11742	PF11909	NdhN		NADH-quinone oxidoreductase cyanobacterial subunit N	Coggill P	anon	Lonsdale D	Family	The proton-pumping NADH:ubiquinone oxidoreductase catalyzes the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides. Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 subcomplexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1]. The cyanobacterial NDH-1 complex contains additional subunits, NdhM and NdhN, compared with the minimal set of the bacterial enzyme and these seem to be specific for thylakoid-located NDH-1 of photosynthetic organisms [2].	25.00	25.00	60.10	59.90	21.10	16.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.59	0.71	-4.89	20	98	2009-06-19 15:22:00	2009-06-19 16:22:00	3	1	89	0	45	90	139	149.60	50	87.57	CHANGED	M...sLLh....oGppFh+........DLEpsGuLAlasPLEGGhEsRhLRRLRAuGYpohhhSARGLGDPpsaLhplHGVRPPHLG+pslGpsuAlGcV.hV.P.ls....pL..ssuKuLVLWlLEGpVLSpuELphLssLsppEPRLKlVlEhGGsRslRWpPLpph	.......................MsLlhoGptFlcDLEppGuLAlYsPLEGG....aEGRYhRRLRusGYpshplSARGLGDspsaLhplHGVRPPHLGKpslu.ptuAlG.laalPP.lshpLppLsssuKGLVLWllEGpVLScuELpaLstLsph-P+lKVVlEhGGtRpFcWpPLpp.h.	0	8	29	40
+11743	PF11910	NdhO		Cyanobacterial and plant NDH-1 subunit O	Coggill P	anon	Lonsdale D	Family	The proton-pumping NADH:ubiquinone oxidoreductase catalyzes the electron transfer from NADH to ubiquinone linked with proton translocation across the membrane. It is the largest, most complex and least understood of the respiratory chain enzymes and is referred to as Complex I. The subunit composition of the enzyme varies between groups of organisms. Complex I originating from mammalian mitochondria contains 45 different proteins, whereas in bacteria, the corresponding complex NDH-1 consists of 14 different polypeptides.  Homologues of these 14 proteins are found among subunits of the mitochondrial complex I, and therefore bacterial NDH-1 might be considered a model proton-pumping NADH dehydrogenase with a minimal set of subunits. Escherichia coli NDH-1 readily disintegrates into 3 subcomplexes: a water-soluble NADH dehydrogenase fragment (NuoE, -F, and -G),the connecting fragment (NuoB, -C, -D, and -I), and the membrane fragment (NuoA, -H, -J, -K, -L, -M, -N). In cyanobacteria and their descendants, the chloroplasts of green plants, the subunit composition of NDH-1 remains obscure. The genes for eleven subunits NdhA-NdhK, homologous to the NuoA-NuoD and NuoH-NuoN of the E. coli complex, have been found in the genome of Synechocystis sp. PCC 6803 which has a family of 6 ndhD genes and a family of 3 ndhF genes. Two reported multisubunit complexes, NDH-1L and NDH-1M, represent distinct NDH-1 complexes in the thylakoid membrane of Synechocystis 6803 -cyanobacterium. NDH-1L was shown to be essential for photoheterotrophic cell growth, whereas expression of NDH-1M was a prerequisite for CO2 uptake and played an important role in growth of cells at low CO2. Here we report the subunit composition of these two complexes. Fifteen proteins were discovered in NDH-1L including NdhL, a new component of the membrane fragment, and Ssl1690 (designated as NdhO), a novel peripheral subunit [1, 2]. The three nuclear-encoded subunits NdhM,NdhN and NdhO are vital for the functional integrity of the plastidial complex [3].	25.00	25.00	31.40	47.00	22.00	19.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.12	0.72	-4.34	21	95	2009-06-19 15:36:07	2009-06-19 16:36:07	3	2	89	0	43	93	99	69.00	52	67.02	CHANGED	lKKGuLVRVsREthpsSlEAtASDsphP.....sYlFEusGElLsl+....GDYAQVRa.phPsPsVWLRlDQLEsh	...lKKGsLVRVs+EphpNSlEAtASDs+hP.....sYlFEspGElL-l+.....G-YAhV+a.tlPTPslWL+lDQLct...............	0	7	27	39
+11744	PF11911	DUF3429		Protein of unknown function (DUF3429)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1072 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 147 to 245 amino acids in length.	39.10	39.10	41.90	41.30	34.60	37.40	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.95	0.71	-4.21	83	410	2009-06-19 16:34:30	2009-06-19 17:34:30	3	3	382	0	189	393	578	145.90	27	71.46	CHANGED	tpsPphshh...LGhuGLlPFlhsshhhhhs....shtths...........................shhhhlsYuAlILSFLuGlhWGhuhptt..............st.shhthshullsuLhu......W.....sshhh....sshh......uhhhl.hhGalslh.hhDhthhpt....shsPsWahpLRhhLTsllshslhlshhh	...................p...Pp.shh..LGhAGLlPFlssslhhhhh.....sh.h.t............................hh.h.lsYGAlILSFLGGl+WGhuhstt........................sphsh.hphshu.llssl..hu......Wssllh.........ssth......ullhl.hhuFshlh..hhDtthhtt................thhPsWa.hthRhhLThlsshslhhslh.s...........................	0	58	110	145
+11745	PF11912	DUF3430		Protein of unknown function (DUF3430)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1305 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 209 to 265 amino acids in length.	28.60	28.60	28.60	29.00	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.36	0.70	-4.51	51	133	2009-09-11 05:55:51	2009-06-19 17:37:34	3	6	4	0	133	133	0	208.80	16	78.26	CHANGED	MKl.....hh.llll....llhlhshh.................hssph...........lshh.Pap....sspCs....................................sss.GhG........as........hsp.Chths..................hhhhptssssshhphphhp..........ttsCt.....ts.hss..hshp....hssCht..................................................st..s.............hshhhhsss.ps.h.....sssoh....lthhh................................ss................pCsss.......shhhhtahssspp....l........ssshohpahCss......sh.shhphC............sssCpstsh......ph.sCs..tssshhtp.spt	...........................MKl......llll.lhhhhshh.........................ssspa......................lshp.sap...sspCs....................................sss.GhG..............ash...............hsp.Chsht................................h.hhtss.sssshh.php.hs............sCp.....ss.hss..psap....hspChp......................................................sst...........hhhhh.s.ss...ps.h......Pssoh....lhsha...............................................ss....................pCsss..................thhhhpahsssps.ht............ss.s.p.hhCss...s..sh..hs..........sssCps.sh........h.pCt............................................................	0	98	133	133
+11746	PF11913	DUF3431		Protein of unknown function (DUF3431)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1346 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 291 to 390 amino acids in length. This protein has a conserved NLRC sequence motif.	33.10	33.10	33.30	33.20	32.70	32.80	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.70	0.70	-4.90	48	316	2009-06-19 16:41:07	2009-06-19 17:41:07	3	6	70	0	237	321	32	220.90	36	63.07	CHANGED	spslVlAphpsED.ssWlpp...l...s-....appsIYsVD...........cs..sush........psPtNKG+EuM...........sYLoYIIDaY-pLPss.hlFlHup+....hsWHNDs..saDssshl+pLphs.hVpppGYsNLRC.....pasPG.CPspl+...Php.....t.s.........ppsscthhsp......uappLFssss.................................VPcslussCCuQFAVSR-plpcRP+p-YlcaRp.......Wllc.......................TcLsDpl.SGRVhEYlWHllF........utps..........laCPctppCYCcs	...............................s.tlVlAphpp-.s.ssWlpp...h.......s-.......aptsIYsVD.................ssps.h..........psPtNKG+EuM....................sYLoYI...IDpYDs....LPsh..hlFhHucc....................htWHNDs....thc.ss....hl..pp.Lphp..hlpc...pG.....YsN..LRC........pas.PG....C.P.spl+......Pht............t.t...........................pttpp.th...hsp..............satcLFssss.........................................................lPch.lussCCuQFAVoR-pl..pp+P+pcYhchRc........Wllc.......................TpLsDth....SGRlhEYhWHllF.................stps.................lhCPpt.t.CaCp.h......................	0	33	85	167
+11747	PF11914	DUF3432		Domain of unknown function (DUF3432)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1326 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with Pfam:PF00096. This domain has two conserved sequence motifs: YPSPV and PSP.	26.70	26.70	28.00	27.10	25.10	26.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.43	0.72	-11.15	0.72	-3.97	6	489	2009-09-10 16:59:27	2009-06-19 17:47:26	3	11	427	0	32	454	0	94.20	81	24.48	CHANGED	A-KAussSosSs.l....ouYsssssoSYPSPl.TSYPSPV.TSYSSPsuSsYPSPVHooFPSPSlATTYPSsosTFQTQVhTSFPoSsVTNsaSS.VoTuLSD	...............V.EKAAPVSTASP.l....PAYSSSVTTS.Y.PSS...I.ATTYPSPVRTsYS.SPAPSSYPSPAHTTFPSPSIATTYPSG..TATFQTQVATSFSSPGVTNNFSSQVTosLo...	0	2	4	10
+11748	PF11915	DUF3433		Protein of unknown function (DUF3433)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1502 (release 23.0)	Family	This is a family of functionally uncharacterised proteins. The family is found in eukaryotes, and represents the conserved central region of the member proteins.	20.40	20.40	20.90	20.80	19.00	20.30	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.05	0.72	-3.82	166	434	2009-09-14 14:57:32	2009-06-19 17:52:00	3	9	77	0	373	464	0	90.50	22	15.65	CHANGED	.pahhsalPsllushlthhapsl-hphptlpPahpL...pp.......susAppSlhls...Ysuphs.hhsshpAlp......pp.Hahlshsohssll.sh.hlsllsu.ul	..............................................h..ahhpalPsllushlthhaphl-hplphlpPahtL.upt..................sssAppolh..ls...Y..huths.hhsshpAlp......pt...Hahlshsshssll..s..hlsllsuu..................................................	1	57	180	310
+11749	PF11916	Vac14_Fig4_bd	DUF3434;	Vacuolar protein 14 C-terminal Fig4p binding	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1661 (release 23.0)	Domain	Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.	25.00	25.00	36.10	27.40	19.00	19.00	hmmbuild  --amino -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.02	0.71	-5.13	38	357	2009-06-19 16:55:15	2009-06-19 17:55:15	3	16	279	0	254	343	2	162.60	47	22.35	CHANGED	-cpLLcpRushIIRpLChhLss.........E+lY+sluplLpp........c...sDlpFsshMVpsLNslLlTusELtpLRppL+...t.t.pp....tshsLFssLapsWC+NsVuslSLCLLupsYEhAasllphhu.....-h.ElslshLlQlDpLVQLlESPlFshLRLQLLEPc+a....PaLhKsLYGLLMlLP.QSsAFphL+sRLpsVs	.....................................................ppLLEtRGshII..RpLChhLss.......EpIa+shuslLtp..............................-.pDlcFAShMVpsLNhlLlTusELh...........pLRppL+....................shpspp....upslFssLa+SWCHNsluslSLCLLs.QsYcpAhsllphhu.......-l..EloVshLhplD+L.....VQLlESPlFsh.................LRLQLL..-sp..p..h.........PaLhKsLYGLLMLLP..QSsAFthLppRLpsVs.................	0	94	148	215
+11750	PF11917	DUF3435		Protein of unknown function (DUF3435)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1788 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 435 to 791 amino acids in length. This family is related to Pfam:PF00589 suggesting it may be an integrase enzyme.	25.80	25.80	26.50	26.00	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.21	0.70	-5.75	20	446	2012-10-02 14:09:14	2009-06-19 17:59:53	3	11	52	0	340	472	0	248.00	16	52.15	CHANGED	lEDlhphh+shlsTsctpFhhGhpRlQLsLhhhLushTusRPsAlLp...........Lpa+DltloLh+sPcG.usshhhl-lpscasKpah.Gtpph....Ns...............FhlPElIa...-PoLlLsP+saLlulLFttpAFps......slsosccLhp.LpVsssptph.L.L+schhDhalFp+s.hpstthcI...spshohsshpshl+phGEIsGFppshpsYphRhGuuctlspSt.lo-upcNllhpH.AsscTF.caYhspplcpDhQulhpGhsspctlhRhssphSRolDsRRPpcLosppctslccpPclpchtccpccL+p..................paGpstcsptss......................hhpchp+tppclpssRpRhpcch++ch+ccFspcQsllDIERQLS..Gpslcp-.hppshppsphhPPpph+LlcpLhshP.upol--E..hpRRhpulcAVsth	....................................................................................................................................................................................................................................................................................................................t..hh............t.t..h......................l.....hc.ph...ph.lhp........t...........h..t.......t.s...s.....h..h.hp...h..h............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	20	91	252
+11751	PF11918	DUF3436		Domain of unknown function (DUF3436)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_18 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF03572. This domain has two conserved sequence motifs: DPRL and SYEP.	27.00	27.00	27.20	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.67	0.72	-3.73	47	2173	2009-06-19 17:05:20	2009-06-19 18:05:20	3	4	1540	0	25	2173	0	53.40	58	14.49	CHANGED	ApVLTAGVQoSLNDPRLhISYEPohlp.P.ttsPthssLo.EpLlAhLQpuI+a-l	.ApVLTuGVQoSLNDPRLhISYEPSsl.E.sP...p.Q.s.PsLosLTpEELLAhlQcsI+aEV....	0	1	3	10
+11752	PF11919	DUF3437		Domain of unknown function (DUF3437)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1910 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 142 to 163 amino acids in length.	21.20	21.20	21.50	23.10	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.99	0.72	-4.27	32	338	2009-09-17 10:53:11	2009-06-19 18:08:46	3	8	258	4	240	340	5	89.90	40	5.22	CHANGED	pphhphHuulLGLuAlVtAFPYtsP.................WlPphLsp.Luphup.c.ss.ltpos+cslu-FK+s+...pDoW.phcpptFoc-..pl-sLc.sl.............lh.oYas	..........t..lhp+HuuVLGLuAhl.uhPYssPs................WhPplLhp.Lus+s......s..D...P........s....sltpolKcslu-F++TH.pDsW...p.cpptFTp-..QLpsLp.sl....l.ssYaA.......................	0	75	131	205
+11753	PF11920	DUF3438		Protein of unknown function (DUF3438)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1942 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 276 to 307 amino acids in length.	25.00	25.00	25.30	25.20	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	288	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.84	0.70	-5.56	25	270	2009-06-19 17:10:54	2009-06-19 18:10:54	3	3	195	0	68	269	20	253.70	42	93.79	CHANGED	h+hhlhhhslhhshsss.ApAsElh+WERlPLslPLpVGpERlVFlD+NVRVGhPss..lsu+LRVQSsGGAlYL+AsEshssTRLQLQDscoGElILLDIsApsttsspsshEPVRIVhusssss.p.t..........sssussusssuss......ts.pts+hpsPlPVVLTRYAAQsLYAPLRTVEPVsGIppVsl+hshcLoTLh..PohPVcAssLuuWpL-shhVTAl+LpNpuspplsLDPRtLQGpFluATFQHshLGPtGsscDTTsLYLVTcG+uhspALlP.pht.hc..........shstp..................sspp	.........................................................hh.....hhhh.hhh.hhs.hu.pA....sElh+WERhPLslsLpVsQERlVFlD+...NV.RVGhPss..Ls..s+.L.R.lQSs.G.GAlYLpAppsh..sTRLpLQsspsG-lILLDlsApt....spt.hE.PV+lV.sspsss...t...............ttttttt.st..t.............t..ps..sphpsPlPVsLTRYAAQpLYAPLRTVEPlsGltpVslchshslsTLh......PshPlpussLuuWp....lsshhVTAl+LpNpu.uptlsL...........D.PRtLp....G....pFhsATFQHth..LGstGs.spDTTslYLVTcG+s.spuhls.t...................h.............................	0	8	32	55
+11754	PF11921	DUF3439		Domain of unknown function (DUF3439)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1105 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with Pfam:PF01462, Pfam:PF00560.	27.10	27.10	27.10	27.10	27.00	26.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.87	0.71	-4.36	20	546	2009-06-19 17:20:45	2009-06-19 18:20:45	3	27	7	32	0	565	0	67.30	55	33.02	CHANGED	oCPGIcYLScWIpKNSull..h.ts.s..ssPDSAKCSGSGKPVRSIICPTTTTTTTTTTTTMPTTTTLPTTTKMSMVKVPLVPPEAFGRVMNACAYFPSYIFLHLVHGLAAVPLVYLVCHASQLL	......uCsDIhYLScWIupHsGlV...hp.t...s..sh....ssPDSA+CSGTNTPVRAVh........ps....oh..............................................................................s..............	0	0	0	0
+11755	PF11922	DUF3440		Domain of unknown function (DUF3440)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1674 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 53 to 190 amino acids in length. This domain is found associated with Pfam:PF01507. This domain has a conserved KND sequence motif.	25.00	25.00	34.30	26.10	24.30	21.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.13	0.71	-4.72	18	1399	2009-06-19 17:24:49	2009-06-19 18:24:49	3	7	655	0	74	628	8	100.50	38	40.47	CHANGED	GVslppMRVspPFtsptpcuLpLY+lIEP-TWu+hluRVsGsNFuulYGsopu..hGa+s.lpLPcua.TW+pYshFLLcTL...Pcph+ppYhcKlpl.lpaW+p+.G...GsLs-...................................ch.cDl.tl.phR-lPSaKRhChsILKNDahC+hhuFu.TKp-ttc+	.............h..t..RlspPa...t.psL..ht.l-sthW.thhtRVtGs..sshYstp......huh.t...h.hP.th.sWppa..hLLpsh...s..h.tt..Y.p+hth.htaatpp.......h.......................................................sa+thshsl.ppDh.hp.htas.sp..........................................	0	15	36	47
+11756	PF11923	DUF3441		Domain of unknown function (DUF3441)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1795 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in archaea and eukaryotes. This domain is typically between 104 to 119 amino acids in length. This domain is found associated with Pfam:PF05833, Pfam:PF05670. This domain has two conserved residues (P and G) that may be functionally important.	26.30	26.30	28.40	26.80	26.10	25.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.55	0.71	-4.49	39	309	2009-06-19 17:27:43	2009-06-19 18:27:43	3	16	254	0	231	326	2	108.90	35	11.46	CHANGED	p.stsppstsphhphlspLsupPpssD.plhtslPVsAPasAlp..caKYKlKlpPGss.KKGKuspphlphF....................................hpstp.....................hspEtcll+sl+...sp-lstsls.ucl+....lshs	.........................t....tttttpphshlssLsGpPhspD.plLhAlPVCAPasulp..pYKYKVKLpP.G.ss.KKGK..A...sKpslshF................................................hpspc..................h.ss+Ep-Ll+ul+...-p-lhpsls.GKVKlsh....................	0	87	138	194
+11757	PF11924	DUF3442		Protein of unknown function (DUF3442)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_890 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 334 to 948 amino acids in length.	29.20	29.20	29.20	29.20	29.10	29.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.79	0.70	-4.82	50	2024	2009-09-11 14:47:36	2009-06-19 18:35:19	3	70	725	2	124	1347	552	264.00	39	30.81	CHANGED	phhspts..pphssthpsp.....ssptspphths............hhsspsssplpphL...sthups....plslshss.chphpssplshl.....hshh...-sspp.LhFsQhuhpp....p.sscsssNlGlGhRp...h.t...ssah.lGhNsFaDh...-hsps.ppR.hGlGuEh.apcahchsuNhYhslosh..+sstshp.thp......................E.RsA.sGaDlphphhLPthPp.....husplhappahGcp..VslFsp...sphppsPpuhshulsYsP.lPllolss....ph.ppupuspspsphs....lplsaphGt.shppQls.stls.......tcsl.tspRa.-hVcRsN	.......................................................................................................................hAp.u..tshGphhtsp......su-tA+shthG...........hsospsspplpsWL....utaGsA..........pVsLplsp..phphcs.S.ph-hh.......hPhh...Dspp......LhFo..Qhuhpp.....p.DcRhhuNlGlG.Ra..h.t.......ssWh.lGhNsFhDp...............Dhsps..ppR...hGlGuEh..WpDYL+hSuNhY..h...houW...+cu.shc...ap....................................p..RsA.pGaDlcspuhL..Ps.aPp......Lu.uplhaEQ..YaGDp.....VsLFsp...............sshp....+....sP..tAlohGl....s....Y.......T.....P.lPLlTlss........pa..+pGpuupscsphu....lplsYphGp..PhpcQLcsppVs......t....tcoL..tGSRY.DhVpRNN...............................................................	0	27	46	86
+11758	PF11925	DUF3443		Protein of unknown function (DUF3443)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1634 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 400 to 434 amino acids in length. This protein has two conserved sequence motifs: NPV and DNNG.	25.00	25.00	25.60	28.20	23.20	24.60	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.10	0.70	-5.78	24	153	2009-06-19 17:37:27	2009-06-19 18:37:27	3	2	74	0	49	152	4	356.40	44	86.77	CHANGED	ssssssuNssslTVs.sussssh...NhPhVSVTlCsPG......o.o..pCpTlDsVLVDTGShGLRlhuoAl.sul.ssLPtpos......uuuslA.ECspFso.uaTWGsV+pADVplGuE.p.........AuslPlQlIuDss.ssslPs..sCsssGs..stsosssLGANGILGIGshstDC..GssCss...ss..hsusYYsCssu..soCsssplPlupQVsNPVstF.usDNNGVll.phPslu.ssGtsSsoGpLlFGIGTQsNNslsu..sshlsoss...sG..hos.sapGp....shss..FhDS...GSNuhFFs.ssulss.....Cu...s.ssa..YCP....soshsloAolsussG.s.ousssFslu.NAssLhuss..shAassLuGs.h....s.sshaDhGLPFFY.........GRsVYhulcpss.ssG......sGP.alAF	.......................s.sssuuNshslTVs...sGssssh.....NhPhlSVTlCsPG.........T.o........pCQTIsNVhVDTGShGLRllsoAl.uul..uLPssss........uGusls.ECutFso.ua..TWGsVRpADVpIuGE.h..........AuslPlQlIuD.u....osssPs.........sCosuuu..shsTsusLG.ANG........ILGIGsh.shDC..GssCss.........os....h.usYYuCssu.....soCss..TosPluQ...QVsNPVstF.AsDNNGVIl.phPslu.ssGuu.SAoGoLlFGIsTQuNNsLsu..ssll..soso...sGs....lou.shpGp.....shss.......s....FhDoGSNuhFFs..su...u...hst..............Cu....stuaYCP....uSopohouTlsutNG.u.ssssohslu.sussLFush..shAhssLuGsh......s.ssh....hDhGLPFFa.........GRslYhuh-tsu.suG......suP.YhAF........	0	6	21	32
+11759	PF11926	DUF3444		Domain of unknown function (DUF3444)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1267 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 210 amino acids in length. This domain is found associated with Pfam:PF00226. This domain has two conserved sequence motifs: FSH and FSH.	26.10	26.10	28.70	28.70	25.40	24.30	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.60	0.70	-5.13	29	318	2009-06-19 17:39:28	2009-06-19 18:39:28	3	14	19	0	231	311	0	192.20	32	39.01	CHANGED	ppssssssphssPDs-FaDF-c.RsppsFtssQIWA.lY.DspDGMPRhYAhIc+Vhss.sF......+L+loWL-sps..psE......pWhstshshu.CGcF+l..upspthcshshFSH.h..hshcpsp+sthpIaP+KGElWAla+sWs.sWsss...t.scphacY-hVElLs.sassp.tGlsVs.LsK........lcGFpolFppptpps.....hhhIPpcEh.hRFSHplPua+hoGcEtp	..............................tt........hshs-s-FasF-ppRs..ppFtssQlWA.hY..D.s.DsMPRhYuhIp+Vhs.....sF.................clploaLcsps..psc....h..........pW.hpp.shshu.CGpFch....sp.p.p.........h.ps.hs...h.FSH.l...............thpts..t............p............t............h............hpIa............P++G-lWAl....Y..+s........Ws...p.Wstp.......s.....phhhcY-hVElls.saspp...tGlpVs.LhK.............................lp.Ga..tolFppt.ptt............hhhIsppEh.hRFSHplPuaphotpc..t............	0	30	117	172
+11760	PF11927	DUF3445		Protein of unknown function (DUF3445)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_501 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 264 to 418 amino acids in length. This protein has a conserved RLP sequence motif. This protein has two completely conserved R residues that may be functionally important.	25.00	25.00	28.70	28.40	22.90	24.20	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.64	0.70	-4.99	75	510	2009-06-19 17:41:17	2009-06-19 18:41:17	3	8	251	0	334	538	505	230.50	26	64.60	CHANGED	hulps.....hc..h.ppWlcl....D.ppYhsphsp+pclLpc.cscpshsh..........................PcupsAshELh-hlhp.aLsp+YP.phFph.......ptss.............hpNphsGpphshshs.........................s......................P.....Lphluc.lpEDhsllhpc.................................sspahLpAuslsFsus.WslspKlGhs......LstIH..sPVPtYc..pclppuh..................p+aFp+lpsscPlpRhNWslps...cs.pLhhss.......tphtphs.t..........ttptpssscphalRsERQoLpRLPcSsAllFoI+TYhhsls-...lpp	...............................................................ul..ht....pphlpl...D.ppYhppht.+tplltp.csppshth....................................Ppsh.A..shEl.hchl...........hp..aLst+YP.ph.Fph.............pts.s.......................hpNphhupp.hshs.t..........................................p...............................................P.......Lphluc.lp-Dhsllhpp...........................................sspahltAuslshsus.Wshpp+hGhs......ltpIH..sPV.Ptac..pplttu..h..................p+Fh.p+lps...sp.slpRhN.....Wslps.................ss..pLhhs...................tthtp.s..................p.ptp.shpphalRsEhQoLhRL.Pp...SsAllFsl+sahhslpcl......................................	0	69	177	275
+11761	PF11928	DUF3446		Domain of unknown function (DUF3446)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_833 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 80 to 99 amino acids in length. This domain is found associated with Pfam:PF00096. This domain has a single completely conserved residue P that may be functionally important.	25.00	25.00	28.80	28.10	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.15	0.72	-3.79	13	977	2009-06-19 17:42:26	2009-06-19 18:42:26	3	16	615	0	79	862	0	79.10	48	22.95	CHANGED	G+Fol-Pss..ssusShW..sEsllSLVS.GllGhsssPuo................ossSSSS.......oSuSotSssL.......Ssolppopss..sIY.S...usPsYSossuDIas-	.........G+Fuh-ss......us..ohW...PEslhSLVS.GllGMsssPso.....................oosSSSS.........sSuSs.t.SssL.........SCo.sp.tS.-ss.....sIY..S....AsPsa...sss.suDIaPE......	0	3	10	30
+11762	PF11929	DUF3447		Domain of unknown function (DUF3447)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_10 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length.  This domain is found associated with Pfam:PF00023. This domain has a conserved SHN sequence motif. It seems likely that this region represents divergent Ankyrin repeats.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.96	0.72	-4.17	607	1243	2012-10-02 12:10:21	2009-06-19 18:47:56	3	305	1	0	1242	1262	1	73.30	47	16.44	CHANGED	Fs.s.c.....IT.p.pCL.phSFLGGNs-IhsECL.K.....h..p..cPs....p.......pC.McaAI.lSHNIDF.VoF..L........hN..E..Y....sl.....c...I.s..........lp....Cs...h......apNLc.....uF....llY	.....................ap.scIT.ppCL.phSFLGGN.-IhsECL.K..............h.p....cPs.........p..pC.McYAIISH.NIDF.VoF..L........................hN.E........Y...sl.........c....I..s........................Lp...........Ct...t.apNLc.uFlla................................................	0	1242	1242	1242
+11764	PF11931	DUF3449		Domain of unknown function (DUF3449)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_769 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 181 to 207 amino acids in length. This domain has two conserved sequence motifs: PIP and CEICG. The domain carries a zinc-finger domain of the C2H2-type.	49.60	49.60	73.20	72.20	44.10	43.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.47	0.71	-4.80	37	347	2012-10-03 11:22:52	2009-06-19 18:56:47	3	14	298	1	237	326	6	185.00	48	37.88	CHANGED	uhtEatlpphsphLspphppThpplcRKpuhTtcEppt.................................................tt..spssppss............................pscsc.p-p-p.laNP.hpLPLGaDGKPIPaWLYKLHGLshpapCEICGNhsYhGR+AF-+HFsEhRHsaGh+CLGIs..sottF+pITpIc-AhpLac+lp.............ppppppph..........csppt..EhEDscGNVhscKsYpDLK..+QGL	........................................................................................................................u..hEhplhc.hschLs.cphptT+pNVpRKQuhTtcERpt.........................................................................pp.pppts.............................pscs-..--..--chlYNP.hpLPLGWDGKPIPYWLYKLHGLslpasCEICGNasYhGp+AFc+HFs.........EhRHsaGhRCLGIP.....NTspFtsITpI--Al.p.LWcKlc...............pppppp..ch...............ps-p-..EhEDupGNVhscKsYpDLp+QGL...........	0	83	133	197
+11765	PF11932	DUF3450		Protein of unknown function (DUF3450)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_773 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 260 amino acids in length.	26.90	26.90	26.90	26.90	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.38	0.70	-5.11	59	359	2009-06-22 08:13:35	2009-06-22 09:13:35	3	6	256	0	117	325	524	242.50	31	91.02	CHANGED	hphsh...........sll....sshhhssus.sst.........................sssls..pshpttsptspsutpSQp+I-phs-pspshht-hcpltccl-sLcl...YssplpchlssQppclsuLpppIsplpphcptlsPLMhcMl-sL-pFlphDlPFht-...cRtpRl.ppLcshMscu-losu...EKaR+lLEAYQIEh-YGpplpsYpupl.sl..sGpphpV-hL+lGRluLlhpohDuppshhWsspsp....pWps.Lss.phtsslscAlclAccQtsssLlpLPl..................ssE	............................................................hhh......hhhhhhsss...sst........................As..sLs..psp.shpsp.tspuu.sp.SQp.+IDphs-pstphhsEhcplpcElcsLpl....Y.pspLpp..hVs..sQpp-hsuL.......ppQlpplcpocpslVPLM.hcMl-u.L.cpaVt.Dh.Phphp.......pR....ppRl....pcL.cphhscADVosu...EKaR+l.LEAYpIEh-YGpplssYpupl.sl....supplpsDhLpLGRluLlhpohDupphhhWssppp......tWpt..lss...s.tpslspuhplApcQhsPsLlpLPl......t..................................................................................................	0	40	72	94
+11766	PF11933	DUF3451		Domain of unknown function (DUF3451)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_877 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 199 to 238 amino acids in length. This domain is found associated with Pfam:PF06512, Pfam:PF00520. This domain has a conserved ADD sequence motif.	27.50	27.50	27.80	27.80	27.30	26.30	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.66	0.70	-4.55	27	544	2009-06-22 08:19:43	2009-06-22 09:19:43	3	20	95	0	211	695	0	216.20	37	12.31	CHANGED	SchSphS.cshpppc..............ptppcppccchp.tpEcscs-ph.+pcspss.pp.t...........ph.++h.......pps.LSlsGSsFssRRsS+u.SlFo..hR....sRt+psGs-s..................-aADDEpSsst.....S-p+........GulhlPhh...p+poutsShs.....S+uS+l....hsspG.....chh.u.sh-sNGhsshhttsthhs.......s.tphlPt...t.......sshp-sphpp....p.psh.hs..shlpp..sttc..p.pshstssh	................................................................S-hScLSSKSsKEcR....................st.pc..c.++.p+c.ptt.pEc.t.-s.-.c.h.K.S-S..--uh++psah...........................................p.sht++hs......................pQo.LSl.....GS....F..ss...R.RsS+s.SlFS...FR.....GRs+DlGSEs......................................-FADDEaSsht..........-sEuR.......RsSLFlPhth.tcRRsSp.....S.s.........S+uS.+hh..........hshsG......Khp....S.sVDCNG.VVSLlsussshs....................ssupLLPt..............................ssos-sph+p....h.sshtho.h-hhpc...ttRp.pshp....h................................................................................	0	15	25	102
+11767	PF11934	DUF3452		Domain of unknown function (DUF3452)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1048 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 124 to 150 amino acids in length. This domain is found associated with Pfam:PF01858, Pfam:PF01857. This domain has a single completely conserved residue W that may be functionally important.	26.30	26.30	26.30	26.40	24.90	26.20	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.69	0.71	-4.85	35	334	2009-06-22 08:24:09	2009-06-22 09:24:09	3	6	142	2	170	321	0	135.60	30	14.91	CHANGED	.stssh..........t..ttss......loLoplL+us..+lslhcFFcclppas.chssl.sshass................plccLcpsashhtsLh++acchapplFhss.............stp..p.............psssphscla+FuWlLFLhh+sc.shphhcDLVsshpLLlClLslllhp	...................................................ttsss.......t..psss...loLTclL+ss..clS............lhpF.Fpc.h+ca....chssls.phhpp..............................................................phccLc+sasV.slla+.Kac..hFpc...lFtss.......................................pp..........................hptssssp.clacFsWhLFlhsKup..hh.htcDLV..sS...apLLLCsL-llhtp..........................	0	42	67	113
+11768	PF11935	DUF3453		Domain of unknown function (DUF3453)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1335 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 239 to 261 amino acids in length.	25.00	25.00	28.40	26.70	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.46	0.70	-4.96	30	316	2009-09-16 16:45:01	2009-06-22 09:26:07	3	9	245	7	222	311	2	219.90	24	24.22	CHANGED	Lhcsp..DssVhKplI.sssslYtllhcal........hssssspphWsphstlKspIlsh.acos.hP......................GlKlsslKFlpplllsQopsss.st...........p.t.ps-hSLupVPssHsllphp.sLEtEuppLL-.tLLshhtpss.....................hsusllsAslNs...............................Luhlh+pRPph...ss+llsulhsass.sh......tss..h+lph+sV-+sl+hhlhphLK.pphs...phsuplpphls...chupshtclscps.p..cpsh..sccspcshc	.........................................................pp..sstVhKpsI.shsplY.hshphh.....................ss.tpthWphhsthKspIlph...hcss.ss......................Gl+hpslKFlptllls.o.tssss............................p.pp-hSLs.hlP....t.s.H..shlpht.tLptEup...t.hL-..hLLphhhpss.........................hsuh.lhsslss..........................................................................Luhlh+pRP.h...hs.cllp.ul.shpssh..........ss..t+splpSlc+sh+hhlhpllK....psss..........hpspl..pphlt.............clutstt-..lhcph.p...tpth...tp......p..........................................	0	68	123	184
+11769	PF11936	DUF3454		Domain of unknown function (DUF3454)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1847 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 60 amino acids in length. This domain is found associated with Pfam:PF00066, Pfam:PF00008, Pfam:PF06816, Pfam:PF07684, Pfam:PF00023.	29.10	29.10	30.00	30.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.79	0.72	-3.77	19	235	2009-06-22 08:32:58	2009-06-22 09:32:58	3	173	80	0	93	184	0	64.00	58	3.08	CHANGED	sppa.TPPSQH..ss..ut.-sT...PsH.lp.....VP-.HPaLTPSPESPDpWSSSSPHS.hSDWSEGloSPss	....................stpa.TPPSQH.....uuuh....-sT........PsH..p.lp..........lss.HPYLTPSPESPDpWSSSSPHS.sSDWS..-us.oSPs..	0	12	21	51
+11770	PF11937	DUF3455		Protein of unknown function (DUF3455)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1386 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.	25.00	25.00	27.70	25.20	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.63	0.71	-4.36	40	358	2009-06-22 12:19:23	2009-06-22 13:19:23	3	4	227	0	214	360	21	143.70	28	72.58	CHANGED	Puup.plthsshGcGsQsYpCps.....sssssh.............................shl..GshAs................................LaDs...uupt.....................................................................................lG+Ha....st....sP........sachp.....sG..SplsGpphu.........sAPsss.........uslsaLhLsupst........Gshssls.V.RlsTsGGsuPs..sCsst...spphpVpYsAcYhFas	.....................................t.phhh.shuhGhQsYpC.......stssth.............................hhh..us.As................................Lhct....s...............................................................................................lGpHa.........s....sP.............sachp.....ss......st..hhupths.........................sAPsss............sslsaLhLpsps.........Gshsslphl.Rl..sTtGGs.sPs.....sCsst......s....tthtV.YtApYhFa................................	0	52	118	175
+11771	PF11938	DUF3456		TLR4 regulator and MIR-interacting MSAP	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1799 (release 23.0)	Family	This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection [1]. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there [2][3]. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria.\	   This family has also been described as a SAP-like MIR-interacting protein family.	20.60	20.60	20.60	20.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.16	0.71	-4.22	23	696	2009-06-22 12:34:13	2009-06-22 13:34:13	3	19	141	0	392	667	1	101.80	23	50.13	CHANGED	ssKCpsC+hlssELc.ulscss.++c...l..tuh+lsscGcpcs+ph................ppSEhRLhEllEslC-+hp-Yslpp.csspp+hhhths.s.tphtt..s..th..............ss.sssLcttCcpllEcaE-plt-aatpcp.t..tslpchLCpcp......sptCp	....................s...Ct...sCph....ls.ph....t.thtph....t.pp...................thp.t.p.pt.th...................t.SEhclhEhh-t..lCp.p...............................................................................................................h.tCpthl.Ep..E-..l.phhhp.....tt.........pl.phlC.p........t.C................................	2	109	147	264
+11772	PF11939	DUF3457		Protein of unknown function (DUF3457)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1822 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 162 to 197 amino acids in length. This protein has a conserved CSL sequence motif.	25.00	25.00	25.20	26.50	21.70	24.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.77	0.71	-4.71	38	586	2009-06-22 12:36:17	2009-06-22 13:36:17	3	2	578	1	62	233	16	150.70	64	90.57	CHANGED	thsshsttLtusaccltpspM+-lPlhN.suLsVcAlGFp.........hap...G.ph......lGlllTPWFMNLVhlP.....s..sspsass.hssGs+tsls.hPuGsa-Flsuphs.......slGsapuCSLFSPMhcFssptsAhssAcAsLssLhs........Ptppss...................................................s.........st.hsR.RshLpGth.s	................Fp.TuPtApVQAAFEEIA+RSMHDLSFLH.PoMPVaVSDFT............................LFE.G.QW.......TGsVITPWMLSAVIFP..............G.PDQlWPh.RcVuEKlGLQ.LPYGTMTFTVGEL..-....................GVSQYLSCSLMSPLS+S.hShEEGpRLsDDCARMlLS.......LPVoNPD............................................................s..PcsuR.RALLFGRR.S.............	0	12	32	45
+11773	PF11940	DUF3458		Domain of unknown function (DUF3458)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_160 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 402 to 419 amino acids in length. This domain is found associated with Pfam:PF01433. This domain has a conserved FSAPV sequence motif.	20.90	20.90	20.90	20.90	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.24	0.70	-5.61	177	1678	2012-10-11 20:01:02	2009-06-22 13:40:18	3	12	1582	20	408	1377	673	363.90	42	42.45	CHANGED	sspp....asLslpQpsPsTssQ......s..p....KpPhhIPlsluLl.ss.s.G..pt....hshp..........................p.pVLplsp....scQoFsFp..sl...s.......pcPVsSL..LRsFSAPVpLch.shosc-LhaLhtaDoDsFsRW-AuQpLhtphlhphlsphp...........tt..t......lss.....t.hlsAhpslL...tc...ssl..DsAhhA.hLsL...Pocsplupth....p..ssDPsulatuRctlppplAptLpsphhtlYp..ph......tt..sap......sspshGpRuL+NhsLsaL....sttss.sts...phshpQapsA....s....NMTDphuALssLsps..p........sp..ppp.....tLssFhp+Wpc-sLVhDKWFulQAsssp..s.....ss...lppVcpLh.pHPsFshpNPNRlRuLlGuFu.sNsssFHstDGuGYpFlu-hllcLDshNPQlAARlh	...............................................p.sppYoLTlpQ...p........s...P...s.....T.....s.sQ......s.....-.........KpP...LHIPhsltLh.ss.c....G.cs...lsLphsG........................pssssV..LslTpuEQTF..sFc....sV.......h.........t..p...P.V.PSLLRpFSAPV+L-a.....c.aS-ppLsFLhpHspssFsRW-.AuQpLhsphl...ttslschp....................pG..ps..........lsl.ss..........c.lh-Ah+sVL...h.D........cpl......DPAhtAplL....oL....PSts.-lA-hh...............chlDP.AItpsR-sl..pcsLAs.pLt.--hhulYp.....st............t..ps..tYp...........s-ttshu+RsLRNssLpaL.......uh.s.-...........s..t..us.............s.LspcQacpA...........s.............NMTDplAALuAhlsu....p......hss......R-t....hhtcFpc+W+..pDuLVMDKWFhLQ.AosPs....s............s.s.....L-.pV+.tLh.pH..u.F..ohpN..PNR.................lRSLIGuFusuNPssFHAtDGSGYpFLs-hl...hcLsshNPQV...AuRLl...............................................................................................................................................	0	111	235	329
+11774	PF11941	DUF3459		Domain of unknown function (DUF3459)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_897 (release 23.0)	Domain	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 110 amino acids in length. This domain is found associated with Pfam:PF00128, Pfam:PF02922.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-10.14	0.72	-3.86	120	2445	2012-10-02 20:10:03	2009-06-22 13:42:40	3	16	1643	30	652	2023	110	89.70	22	15.94	CHANGED	haRpLLsLR+pc..PtLsss....phsssp.s.hhussslhspa+h.......sss.......tLt.lhhNLus...pssshs...........ssuclLausssstt..................sspLss.....tusshh	......................................YpcLlsLR+pp.......PhLs.tu............php.s..lt....s................s........s....s...s..h....l..hhhcch.............psp...............sLl.llsN...los.............pshshs.................tsstp.l..l...h.ss..ttst.....................shpL.s.hphhh.h...............................................	0	172	395	542
+11775	PF11942	Spt5_N		Spt5 transcription elongation factor, acidic N-terminal	Bateman A	anon	Bateman A	Domain	This is the very acidic N-terminal region of the early transcription elongation factor Spt5 [1]. The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4 [2].	24.20	24.20	24.30	24.20	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.89	0.72	-3.37	23	279	2009-06-22 13:40:14	2009-06-22 14:40:14	3	21	236	0	194	277	0	95.10	31	9.27	CHANGED	FlDhEAEVDD-E-E--.-p-t..s-..ptt.hhtph.............pcc+pp+ph-cccppppctssccls-hl.+..cRY.......tcp.....sstpstpsssshlspp...hLLP	..........Flt.EA-VDDE..-E-E-..-..E-.tsp-l..hp.t....tt..lcpst..............................................................hppD-pppR.chs..pphpp.pp.c.stEcluchh..+..c+Yucpp...........shttuust.usslsQp....hLLP....................	0	53	97	162
+11776	PF11943	DUF3460		Protein of unknown function (DUF3460)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2362 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 70 amino acids in length. This protein has a conserved WDK sequence motif.	25.00	25.00	52.00	51.90	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.00	0.72	-3.89	22	216	2009-06-22 14:40:06	2009-06-22 15:40:06	3	2	207	0	69	136	18	60.20	49	91.95	CHANGED	s.YpS-hTpFlspLKtc+PpLtpcQ+tGRALLWDK.slDh-tptchcsu+VsQ+PYVYpsp	....YpS-hTQFLspLKppKPpLEpcQpcGRuLLWDK..slDhE.Eppp.hptA+VsQ+PYVY.pp..	0	9	37	53
+11777	PF11944	DUF3461		Protein of unknown function (DUF3461)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2125 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length. This protein has two conserved sequence motifs: KFK and HLE.	25.00	25.00	58.30	50.50	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.65	0.71	-4.28	11	664	2009-06-22 14:41:40	2009-06-22 15:41:40	3	1	661	0	62	158	6	125.00	83	97.46	CHANGED	MYssLcolGIssscpIE+YTLRpEuspDILKIYa+KpKG..-hFuKSlKFKFPRQpKoVlsDuGu.psY+ploEIussLphll-ELDplsp..+p+p-sDlKpclLcDL+HLE+VVssKIsEIEccLEcL	..MYDNLKSLGITNPEEIDRYSLRQEANNDILKIYFQKDKG..EFFAKSVKFKYPRQRKTVVAD.GlG.QGYKEVQEISPNLRYlIDELDQICQ....RDRS.....EVDLKRKILDDLRHLESVVoNKISEIEADLEKL..	0	6	18	40
+11778	PF11945	WASH_WAHD	DUF3462;	WAHD domain of WASH complex	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2071 (release 23.0)	Domain	This domain forms part of the WASH-complex of domains and proteins that activates the Arp2/3 complex, see Pfam:PF04062. The Arp2/3 complex regulates endocytosis, sorting, and trafficking within the cell. The WAHD domain attaches to the FAM21 proteins via its N-terminal residues and to the microtubules via its C-terminal residues.	24.20	24.20	24.20	25.80	23.30	24.10	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.69	0.70	-5.12	6	199	2009-12-01 10:25:16	2009-06-22 15:43:54	3	8	109	0	106	172	0	237.80	44	56.81	CHANGED	EuQsYSVPlIpPDLRREEul+QlsDALQYLppVusDlFsRIspRVEcNRs+LQAIssRlplAQAKIcKI+GSKKAhKVFSSAKYPAsDcLQ-YsSlFsG.ss-shp.K+s+a+lQoKhhsLD-+ulQEKLpYasVplNs+pccc.....Dss-EGLGSLP.RNlsSVSSLLLFNTsENhYKKYVhLDPLAGsVTKT+sslEsEcEEKLhDAPloITpRpQLERpsAENYFYVPsLGpVPEIDVPshLPDLPGlADDLhYSADLGPGIAPSsPus..IP-LPohs..T-sl.-sutscppttt.sPP	...............................hh..t.t...sh.phhpsLt.Lpth.tplF..p.plptplcps+pplp........sIsp+lshAQAKl-.pl...pG.S..+K..AIpVFSuA....KY.P.A...s....cph..p.c..asul..F.........s...s...spc.....s...h...........p.p....s.........p.h.........c....l.......p...s.............c..t......p......hs.c..psl...p.Ecl...p.......ha.......Vpspp.p..p.t........sptccGLGsLP.ps.lsSloSLLLFNTsEN.h.Y...........cc.....Y.....s..h....l.D...sL...t.....u....s....hs.c..oc..hhlt....p...p..c.....c...cLh-APhSIs.+R.-pLcpps....s-s..Yh.Y..lPsLG..pV.P-I..D..VPshLP..DLPGIAsDL..hYs.s.Dh.s.....su..IAPSssss....lP-LPsht..sp.............................................................	0	41	51	78
+11779	PF11946	DUF3463		Domain of unknown function (DUF3463)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2277 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 140 amino acids in length. This domain is found associated with Pfam:PF04055. This domain has two conserved sequence motifs: CTPWG and PCYL, plus a highly conserved CxxCxxHC motif.	25.60	25.60	25.80	27.60	25.40	24.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.04	0.71	-4.58	67	326	2009-06-22 14:45:43	2009-06-22 15:45:43	3	8	316	0	145	297	55	138.20	51	37.89	CHANGED	hhlSPGYuYE+AP-..........Q-pFLsRpcT+pLFRplht....tspp++.....WpFNpSPLFLDFLtG...pp.sYcCTPWGsPohslFG.WQ+PCYLl.sE.GYspTFc.......ELMEpTcW-pYG....supsP+CusCMlHCGYEsTAVh-shtp.hphhcssht	.................hhlSPGYAYE+APD..........Q-HFLs.RccT+pLFRclFt....tGc.t.++.....Wp.FspSsLFLDFLsG....pp....sYcCTPWGsPshslFG.WQ+PCYLl...uE.GYspTF+.......ELMEsT-WDpYG....sGp..KCAsCMsHCGaEsTAVhcohspPhcshps...ht..........................	0	44	98	125
+11780	PF11947	DUF3464		Protein of unknown function (DUF3464)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2676 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 137 to 196 amino acids in length.	25.00	25.00	52.10	52.10	24.70	24.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.06	0.71	-4.76	29	127	2009-06-22 14:52:24	2009-06-22 15:52:24	3	4	99	0	66	129	115	147.80	32	82.77	CHANGED	.tss+pshsFc....Pcppppt.tt............................pstptptppppp........................tttt........psIPchVusRMhRRluhhoGlPohlGhusFlhuYhllspslh-.lPshlsllsShhhFhlGllGLSYGlLSASWDpp.sGSL...........LGhpphp.Nl...................sRhhpuh+stpp	.................................................................................................................tp........................t......................................tptp.ptttttt.........................................tpppptsIPpsVupRMh+RhuhhsGlPshlGhusFss.Yhlhsp.thh-.lPshsshhsShhhFGlGllGlSYGlLSASWD.pp.GSh...........LGhpEhptNh...................schhpuh+tt...........................	0	16	44	59
+11781	PF11948	DUF3465		Protein of unknown function (DUF3465)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2827 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 131 to 151 amino acids in length. This protein has a conserved HWTH sequence motif.	25.00	25.00	25.30	25.20	22.70	21.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.63	0.71	-4.33	31	258	2009-06-22 14:56:44	2009-06-22 15:56:44	3	2	187	0	36	166	4	137.10	50	92.21	CHANGED	hpthhhh.h...hslhss...................huhs......htus-s.............................tlppAFpscQSslQVpG..........pGsVh+lLPDDscGSR..HQ+FIL+L...so............GQTlLlA....HNIDLA..PRlssLphGDpVpFhGEY...........EWNs.KGGVlHWTH+DPp..s+H..sGWLKHsGphY..p	...........................................................................................................................ssss.............................sLpQAYps.....pQ.SDl..QVQG..........hGpVsKV..LP..DD.N-GS+..HQKFIL+L...sS...............GQTLLVA....HNIDLA........PRIPsLchGDpVEFYGEY...........EWNc.KG.GVlHWTH+..DPp..sRHs.cGWLKHNGplYp.............	0	10	25	32
+11782	PF11949	DUF3466		Protein of unknown function (DUF3466)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2541 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 564 to 612 amino acids in length.	25.00	25.00	25.60	26.10	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	599	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.22	0.70	-5.95	28	183	2009-06-22 14:58:19	2009-06-22 15:58:19	3	3	170	0	42	145	7	542.80	34	98.04	CHANGED	hspplpLsslulLsusu....ssusA.........slYcllpls..............shssshpss....YuhAlssssp....................................................hsssucs+hph..t.........csssGlsh...t--s.ash-.ppapY.......hpshstsph..sasssps.aAph........................t.sWhs.h..pslssssssss...ssh..sps...................hsohsshlpul..sssGht..VGstosstp................t..h.hpsFppRuhspstst.........lsP...............sptspsGuassshs......hNG..s..lsVG.sSpshusss.....sp............hptsh.s.......ts.s...sh..............................sh......ap.s+AhlW.hDsss.............lsp...pph.shs.psssDssh..hhpupuhulsssG.........hshGsuassh.sscssh.......hpsulahspp..sps.sht.....sWssp..............DpshpsShAsDINcN.....................sllVGpt+p.......sGshss+hFhhDss...sss..spal.........s.....ss.FasGu...uocstuINNpsplVGhl-spssp-.....+sRt+pGFlYshss................pp.hsh.sstsWhhc..-lpsu.s........sshspssca+IlpAssINDsGsIsATAhhppsu......Yc...spup.sh..........susGt..s.phsVsVKLhPhsu....us.pss.lpscss-s.pshERp........GAu.hu..WhsLhsLs.Llhh......RR+	.......................................h.shphpllAhulLlusp......sAsA.........AlYpVhEls..................ssstshtss.......aGlAIpssss...............................hshsucs+hphsss.........css-GlsY..........p-Es.s.F.uh-..psasYs....-....hpsacpYChsph..hY..o..o..Cps...WAssph..........................s.tWps.......-.lsuspsssu....hAa...lts.........t.ssh........spStssllNul...sssups.......lG.pststphs........................t.hh.spshptR...ps........lsP.............t.spsl.stuWp...........ssu..s..hsVGShSps.sssp.....u....................................................................................sh.........ato+sslW.hsusu................ssp......hsh..stu.s..s.scs.sp.....hhpuSht..s..lspsG........splhuVGYsoa..ssssph.......hpAul.F.hss......sss.s.ts........sWssp.l...sshp.p.ss....DhhaoNSlsoDlNcN.....................hlslGsAK+tt.............sGus..sN+hFlh-ss.....oss....usal.........o..........sslFFoGu.....uucusuINshNplVGpl..Dssss+E.....tGKPRRKRGFIYshusst..............................ss.u+..hthhss+uWhLD..DLT.sss........sssssNspaRIl-AoDINDu.....GlIuATAh+sssu.......Y-..osupsuh.........................sussp....-plVAVKLhPIss......us..sss.Ip....p+....us-p..pssERp........Guu...hGhhhLhsLu.l.l.GF.....RR+.............................................	0	8	18	30
+11783	PF11950	DUF3467		Protein of unknown function (DUF3467)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2299 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and viruses. Proteins in this family are typically between 101 to 118 amino acids in length.	25.00	25.00	25.50	26.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.17	0.72	-3.97	52	326	2009-06-22 14:59:57	2009-06-22 15:59:57	3	3	305	0	126	294	210	88.80	37	81.29	CHANGED	Mppppttt...........................................p.....lplc.lsp.......pshpus.....................YuNhshlsp.SspEFhlsF....ht....hh.ssts.psc..........lpsR.....llloPppAK+LhpsLpcslpca....EptaG.......................................................................................pIct	.....................................p.................................................ptp....lp.I-..Lsc...........-sApGs.....................YuNlAlIsH.SsoE.FllDF...............lp.......hh.PGhP..cup..............VpSR.....llloPpHAKRLlpALp-Nlt+YEptaG.Ip........................	0	59	106	118
+11784	PF11951	Fungal_trans_2	DUF3468;	Fungal specific transcription factor domain	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2291 (release 23.0)	Family	This family of are likely to be transcription factors. This protein is found in fungi. Proteins in this family are typically between 454 to 826 amino acids in length. This protein is found associated with Pfam:PF00172.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-12.30	0.70	-5.86	90	3818	2012-10-01 23:57:08	2009-06-22 16:07:12	3	72	166	0	3117	4021	1	286.50	11	52.41	CHANGED	hll.paa...hsplss..hhsshsps................tssatphllshuhpst.................slhpulluhuuhah.......................pth...p........pppthpattp..ulptlppslpphpppts.........................pphlss....l...Lhlshh................-.....lspus....tt....Wth.HLpssppllpphtt...........................t.ptsp..............thpahhphhsah-llushsts...........................................................................ptshhshpthpphhps...........................st.t...........hc....hhGhsss......lhhl.....luclspLspptcptptp...............................................phtppspplppplp.php.p.sshptthssttthtpht...................................hph.aphushlYlh..phl.................hshsss.........................s.plpphlpplhphlptls....sssh............tsLh...a.........PlFlsG...spshss................ppRphh..........pph.hppht....pph.....ushppshpl..lpclWcppc..................................st............................phc..W..hclh..............c................................................hshslhlh	...............................................................................................................................................................................................................a........h.......................................p...h.t..t.h.h..........h.shpp...........................................................................hlhp.u.ll..u.h..u..u..h..ah........................................................t.....t......................tttsh.pahtt.......u.l.ph.l.p.pt.l.t..p.ptt.p...................................................................tt.h....l.ss....h........hhL.hhh..................................................c...............hht.sp.....tp....................h.....H.h.pu..s...h.tllp...h......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h......................................................................................................................................................................................................................................................................	1	361	1347	2518
+11785	PF11952	DUF3469		Protein of unknown function (DUF3469)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2159 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 108 to 439 amino acids in length.	27.60	27.60	28.00	28.50	26.30	27.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.77	0.72	-4.29	18	183	2009-06-22 15:08:59	2009-06-22 16:08:59	3	7	89	0	117	169	0	88.40	34	28.79	CHANGED	l-shRshhEo-cpWphR+cFlhpphssa........................thDcLlsLuhlauNhsFLGC+Ysp.clh-+lhcMAEGIsltcs.ppp...pRsplhtppp	....................l-phRs.tEo-cpWchR+cFlL+phsca......................t.ph..-pLluLShlWuNtlFLGC..pYsp.clh-KlhpMu-GItlpptsphp...pRs.l.tp..t.....................	0	33	45	80
+11786	PF11953	DUF3470		Domain of unknown function (DUF3470)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2503 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00037. This domain has a single completely conserved residue N that may be functionally important.	23.20	22.70	23.20	22.70	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.01	0.72	-4.36	133	1106	2009-09-16 09:23:58	2009-06-22 16:12:12	3	11	970	39	322	784	1301	43.00	43	39.76	CHANGED	ppp...alcLNu-LAc..tWP....sITp+K..-shsDA-cWc.....shpsKlp.h.Lpc	............ppalcLNAELAc..tWP....sITc+K..sshsDA--Wc.....GhtsKlp.h.Lpc........	0	86	190	252
+11787	PF11954	DUF3471		Domain of unknown function (DUF3471)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2961 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 98 to 114 amino acids in length. This domain is found associated with Pfam:PF00144.	26.60	26.60	26.60	26.60	26.40	26.50	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.28	0.72	-4.16	67	608	2009-09-14 14:36:04	2009-06-22 16:15:38	3	30	431	0	263	599	75	102.60	19	21.22	CHANGED	thpttttsshsstsLspYsGpYpps......h.........Gshslshcssp....Lhl.phssps.....t......hpL.hths..tspFhhchss...hp................hpFphs.ssGplsphshp.....ts..................hpshthtphs	...........t...t..tssssstsLpsYsGsYpps....h................h.......GslpV...p..t....c.s.sp.........Lhl.phssps....t............hpL.pa.hs...tcp.F.hhp..hss......hp.......................htFph..s..s.Gp.hsphphphs.............................t............................................	0	85	167	217
+11788	PF11955	PORR		Plant organelle RNA recognition domain	Moxon SJ, Barkan A, Coggill P	anon	Pfam-B_1780 (release 8.0)	Family	This family, which was previously known as DUF860, has been shown to be a component of group II intron ribonucleoprotein particles in maize chloroplasts. The domain is required for the splicing of the introns with which it associates, and promotes splicing in the context of a heterodimer with the RNase III-domain protein RNC1. All of the members are predicted to localise to mitochondria or chloroplasts [1]. It seems likely that most PORR proteins function in organellar RNA metabolism [2].	20.50	20.50	20.70	23.50	19.70	20.40	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.02	0.70	-5.69	27	336	2009-09-11 12:40:23	2009-06-23 17:10:07	3	12	23	0	211	323	0	298.50	30	73.17	CHANGED	hh+-.sLDph..lp+p+cl+hshpl+cllhupPs...ph...........lslptLsch.pcpLsl........+sh.sFlc+aPplFclah...........tspt.hthpLTststsLhpcEtplhpppp..sshss+LpKLLMhohs+.plsLcpltpl+t-LGLPcDFcssll.caPshF+lsp.......tsstphLELlsa...cssLAV..oslEctt..p................ttthppthsFs.lpaPpGaplp+phpptl.........pcaQchPYlSPYp...ssp.pls....sso..tchEKRsVuVlHElLSLTlEK+sphc+LscF+ccaslsp+hpchll+HPGIFYlStK...spppTVhLREAYccs.pLl-+..sPlhhh+-KhhcLhphsthtppt	..............................h+s.thDth..hppp+ph.phhhtlhphlhppss...th................hslp.ltph.tp.ltl......hthhtalc+aPplFphh..............tt..hhplTsphttLhtcEtthhpp.pp...s.hsp+LpKLLMhoh.s+.plslpplttl+h-..LGLPpDF.pss.ll.pa.Pph..Fplsp...........pttthLcLssa....sspLAl..oshEpttt..........................t..t.tthsFs...hphP.pGap.hpcphpph.l.........pcaQ.clPYhSPYp........csp...tlp.....so....tphEKRsVullHElLSLTlcK+h.hcplspF+cthsls...pp...hpphlh+.HPslFYlSh+......spppoVhLREuY..p........p.........s..p..Ll-p..sP..lhhh+c+hhpLht.sh....t.........................	1	21	125	171
+11789	PF11956	KCNQC3-Ank-G_bd		Ankyrin-G binding motif of KCNQ2-3	Cooper E, Coggill P	anon	Pfam-B_10256 (release 23.0)	Motif	Interactions with ankyrin-G are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system [1]. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 [2], that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3 [3]. KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2 [4]. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3) [5].	20.50	20.50	24.00	67.00	18.60	18.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.45	0.72	-3.96	4	127	2009-06-24 10:53:54	2009-06-24 11:53:54	3	9	37	0	50	111	0	100.90	62	12.78	CHANGED	s.pDpsushshpussR-SDTsLSl.SVsHEELERS.SGFSISQs+-sh.shGss..............Auuus..ps+sRP.alAEGEoDTDoD.aTPsGs..PlSuTG-G.hu-ssWsu	.............pDp.usR.pcushRDSDTslSl.SVsHEELERS.SGFSISQs+Esh...shss.s.................uusu...hschRP.YlAEGEoDTDoD.hTPsGs..PhSuTG-G.huDssWs....	1	2	6	19
+11790	PF11957	efThoc1		THO complex subunit 1 transcription elongation factor	Wood V, Coggill P	anon	Pfam-B_2059 (release 23.0)	Family	The THO complex plays a role in coupling transcription elongation to mRNA export.  It is composed of subunits THP2, HPR1, THO2 and MFT1 [1]. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm [2,3].	21.00	21.00	34.60	25.00	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	492	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.76	0.70	-6.00	21	319	2009-09-11 16:24:37	2009-06-24 18:08:11	3	16	247	0	226	332	6	432.10	28	70.86	CHANGED	tplhsLLDllhhhsc......pEp..spsuhlFa.Llc-llDh.TlssCcclFs.YlESRh-phpptphhp..+sh..............lLRpCN-LLRRLS+.....s.ccssFsGRlhlFLsphF....Plu-+SulNl+G-aps..ENlTsas.........................c.s.pppssssshclDhs..........................................................hYshFWuLQpaFssPspl...asst.phssFcpslcsslssFpphpp....-h.tp.ttptpt...-sptusc+ptss.-s..................p-hssu....FssKYLTuccL.....h-LplsDss.............FRRplLlQhLIhhpalhslsppppsp..............psh......hhLspccspahpphcptltphLppsh..p.......GthFhRhVcplLsp-csWlpWKsEGCP..shccs......hshtsh.ssccs......hpKhhhs...h............h.hGstsLshLhp.cspsulcpLKctpR.hpl......Pshcsahpslh-schchDhupsp....ppp.thcsctspsW+sLRlhu+ppLttFs+ls-s.pslcslh.........-t.sspcsshh.pshsp.ppcch	......................................................................................h.thlslh..hsp..................pt...spssh.ah..Llt-lh-s.s..lstCcplFs.alEpphph..hpt..p.hh...p..Kph.................................................lLRhCN..-...LLRR.LS+.............s..psslFCGRl.lFLuphF....PLu-+S.u............lNlp......upash...-NhThas...............................p.tptptsss..pth.lDhs................................................................................................................hY.hFWuLQchFpsPsph...apt...........patsF...t..pth..ptsLssFp..phph.........p..........................ptpt.pcch.tt..t.....................................................t..tsp........a.s.KaLTopcL............hcLp....Ls...Dss.............FRRplLlQhLIlhpaLhs.sphpptp....................................................hLsppp............ppah..pphpp.tl...hphLppss...c............GthFhchlcplLp.p-csWspW.....K.t-.u.Cs..shp+.............ts......t.s.ppt.................hpKhh.........t........................................h.hGs...pLspLhp....p.sp....s....hpthcs......pR....h................Psl.ppahpth.h-...phD.tp..........................cpphth.sp....tshsW+sLRhhu+p.....p..thF..p...h...s....p.....ptl....hh......t...............p.........................t................................................	1	81	129	187
+11791	PF11958	DUF3472		Domain of unknown function (DUF3472)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2598 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, eukaryotes and viruses. This domain is typically between 174 to 190 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.	25.00	25.00	26.50	25.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.28	0.71	-3.94	23	181	2009-06-24 17:14:14	2009-06-24 18:14:14	3	13	133	0	72	188	25	176.30	25	40.36	CHANGED	YhGhQssu.......pocRplL.FSVWustsocss..h..-.........upsshss..pFGsEGo.Gspsh.hsYPWpuGpsY+Fplpst....psGtohasuahpDss..s...p..cahhIAShphP+ssshlsssto...FlEsFs....scpGshsR.puaas.spauhstts.phhclhpsshosssssspt..phsa.suGsss.sthalpssGhh	.............................YhGhQsps............pspcplL...FSlWsshsssss.....h....h..........ussspss....pF.GsEGo..Ghpst.hsas.Wpsu.p.tY+hhlpst......tss....pTpa...ssahpDss..s............s..phphIuohchPpsssshstshu..FlEsas......ppGptt...R..tuhhp..stauh..shss.....ph.phpptp....hohs.ssp......pa.thuss..s....thhhhpssG..t.................................................	0	35	53	61
+11792	PF11959	DUF3473		Domain of unknown function (DUF3473)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3065 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is about 130 amino acids in length. This domain is found associated with Pfam:PF01522. This domain has two completely conserved residues (P and H) that may be functionally important.	29.60	29.60	30.30	31.30	26.20	29.30	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.83	0.71	-4.73	51	224	2009-06-24 17:18:14	2009-06-24 18:18:14	3	3	209	0	97	225	89	131.50	30	46.29	CHANGED	SSlaPlp.HD...hYG....hPcu.PRhP.aphsssst.....................lhEhPloThplh....stplPsuGGGaF..RlhPYs.....lh+hslpplNpps.pPslFYhHPWEl..DPsQPR....l..shshcs+FRHYhNLspsptRLcpLL.....p-Fcasphsplhtptt	............................SSl.Psh...s...pYG.....h.ps..PRhs.athtpt.........................lhElPsoss.hh.....hplPhuGGhah..RhhPht......lh+hhlppl.cp-.ts..hlhYFHPWEh....Dst.pP+......h...phshh..p..phRpassh.pphppRLcpLl.....psapasphpphh...th.........................................	0	34	79	92
+11793	PF11960	DUF3474		Domain of unknown function (DUF3474)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3095 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 126 to 140 amino acids in length. This domain is found associated with Pfam:PF00487.	27.80	27.80	27.80	27.80	27.70	27.70	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.02	0.71	-4.15	30	528	2009-09-16 09:00:21	2009-06-24 18:21:57	3	3	223	0	164	530	0	79.10	35	20.44	CHANGED	MAoWVLSEC.GL+PLP.+lY.s+PRsuh....tpssss..plRhhssspshs.s.th....hs.s..t.....RN....WuLpVSAPL.Rlsolsc--cc...................ppspcFDPGAPPPFpLADIRAAIPKHCWVKDPW+SMSYVVRDVAlVFGLAA	......................................................................th................................................................................................................................................s....P....t....s.P.PF.olu-I+sAIPtHCap+sshRShSYVl+Dlsls.....h........	0	36	99	143
+11794	PF11961	DUF3475		Domain of unknown function (DUF3475)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3098 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 60 amino acids in length.  This domain is found associated with Pfam:PF05003.	29.70	29.70	32.00	30.90	23.70	23.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.49	0.72	-4.14	20	207	2009-09-11 16:23:54	2009-06-24 18:24:45	3	4	18	0	134	194	0	55.90	43	11.06	CHANGED	ILAFEVAsshoKsssLhc.SLS-pslppL+ppsLpS-GVcpLVSsDpstLLpLusAEh	.....ILAFEVAsshsKsss.Lap.SLS-pplp+L.+pclLpS-GVppLl.....SsDps.LLpLAsA-h......	0	11	78	109
+11795	PF11962	Peptidase_G2	DUF3476;	Peptidase_G2, IMC autoproteolytic cleavage domain	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3119 (release 23.0)	Domain	This domain is found at the very C-terminus of bacteriophage parallel beta-helical tailspike proteins. It carries the enzymic residues that induce autoproteolytic cleavage to bring about maturation of the folding process of the helix in a chaperone-like manner. The domain thus mediates the assembly of a large tailspike protein and then releases itself after maturation. These C-terminal regions that autoproteolytically release themselves after maturation are exchangeable between functionally unrelated N-terminal proteins and have been identified in a number of bacteriophage tailspike proteins [1].	25.00	25.00	25.30	25.40	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.53	0.70	-5.24	19	176	2009-06-24 17:27:32	2009-06-24 18:27:32	3	11	141	9	16	159	78	206.70	42	34.28	CHANGED	ssstIhuStuspss..tsYslshGhGsssss..stslKhp.....uhsGslphsGslssuu..uDYAEhFEShsGpsIcs...GhlVTL-..G-KIRhAptuDp...hlGVlSpTuullhssushpWpsRYLpsEFGshlYcphp......D-........pus........hhchPh.NPcacPshc..YhsRpcRsEWslVGLlGQlhVRsDpTVpsG.chlp..ups.G......IuTpss..pG..hpVMclTssastp+GhulALs....hl+	....................usptIhup.u.pu-....puYShhhutGsspssp...shssKW.......upsGphhhsGAshsuS.hoDaAphFEohDsphI-s...GYhVThs...t-KIRhAsssDs...ILGls.....SuTsAlIusuuuhpWpcRYhpDpFGth.Y.psp.....................................up...........phtPllNs-aDPspc...YluRc-RsEWhsVGLIGQhhVRsDsTspst.sYhc..sss.G........IATKu-..sG..ahVhKhTut.......s.h.....h........................	0	7	9	10
+11796	PF11963	DUF3477		Protein of unknown function (DUF3477)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3147 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in viruses. Proteins in this family are typically between 246 to 7162 amino acids in length. This protein is found associated with Pfam:PF08716, Pfam:PF01661, Pfam:PF05409, Pfam:PF08717, Pfam:PF01831, Pfam:PF08715, Pfam:PF08710.	25.00	25.00	30.80	30.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	355	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.19	0.70	-5.46	4	151	2009-09-16 08:59:33	2009-06-24 18:29:47	3	10	56	0	0	167	0	295.00	47	7.14	CHANGED	MuKhuKYGLGFKWAPEFPWMLPsAuEKLuNPp+SEEDGhCPSsAQc.cstGhshsNHV+VDCpRL.u.ECCVQSulIRDIFVcEDPpcVEs.ThhALQ.GoAVLVKPshthSlpAhtsLGshPKshsMGLF+RhslCNTtcCssctHVAapLahlpPsGVChGsGcFlGWhVPlshhPpYu+pWlQPWslhLRKsGpKGuhsScHhRpuhphsVYDFsVEDAht.VHsEPKGKaSpKAYALl+sYRGlKPlLaVDQYGCDYoGsLAcsLpsYG.-hTLp-M+th.slWtssh-h-VsVAWHVsRDsRhsMRLQohATlpulsYVApPTEDlVDGsVVl+EPsHlLussuIlL+hPs	............................M.KhsKYGLth+WAPEF.Whh.sAtEcLssP.pS-.shhCsosuQt.cshGhs..NHVhlDCppl.t.EhpVQSslIR-Ihhppc...lEs.h..Alp.tpAlLlpssh.......hshGs.PpshsMGLF+ph........tsptaVsapL.hhpss.sshGt.pFlGWhlPhshhP..s+pah..h.hhlcctGpc.sh.ps+hhtshp..sYsFpVEDAh-.V.HDEPKGKaScKAYALl+sYRGlKPlLaVDQYGCDYoGsLAcsLpuYu..-hTLp-M+th.slWtpshsh-VsVAWHVsRDsRhVMRLQohATlpulsYVApPTEDlVDGsVVl+EPsHlLussuIlL+hPp.	0	0	0	0
+11797	PF11964	SpoIIAA-like	DUF3478;	SpoIIAA-like	Assefa S, Coggill PC, Bateman A, Eberhardt R	anon	PFAM-B_640 (release 23.0)	Family	These proteins adopt an alpha/beta SpoIIAA-like fold, similar to that found in STAT (Pfam:PF01740). They adopt open and closed conformations arising from different arrangements of their alpha-2 and alpha-3 helices. They may be membrane associated and may function as carriers of non-polar compounds [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.48	0.72	-3.76	151	602	2009-09-14 13:55:16	2009-06-24 18:34:40	3	3	394	6	265	584	59	107.30	20	83.94	CHANGED	sll.slphs..GcloppDhcp.lhstlcph.hp..ppsplplLh-hs.sh..puhsh.tAhhpph...h.....hp.phpc...hc+lAllussp.ahphhsphhsh.h.....hssph+hF..pppspAhsWLpp	.............................................hlshthp..Gcls.pp-hcp....hhsh.lctt.hp....ppsplp.lLhchs..ph....pGh..sh..sA..hhcsh.......pht.....hp..phpc....hc.+l....A.llu.ssp.Whphh.s..plhsh..h.......hstcl.+hF..scppcAhtWLp.t.....	0	106	181	232
+11798	PF11965	DUF3479		Domain of unknown function (DUF3479)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_1065 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF02514.	27.30	27.30	27.80	30.40	26.90	27.20	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.66	0.71	-4.44	61	302	2009-06-24 17:37:06	2009-06-24 18:37:06	3	6	209	0	139	323	268	160.50	33	12.73	CHANGED	h+lVhloh-sphsuultpAstpLppc..hsuLclshasss-htcsstshpphppslspADllhuohlFhE-hlpslhstLpstp.pscshlsh.Shsplh+LT+lGpFsh....spspuuhhshlK+hts...pppusspspt.......phphlRplP+lLKalP.GKAQDlRsah	..................+lVhlsl-spapuulppAsp..pLspp...h.ul-lssahspEL...........ccstsh...pphpp-lspADlhluSLlFhE-hsp.hlhpslpspRpphcAhllF.ShPElM+LsKlGsFsM...........upspuuhsphhK+ht.......p.p..p...u..s.shtsu....................hlKlL+plP+lLKalP.sKAQDhRsah............	0	38	82	118
+11799	PF11966	SSURE		Fibronectin-binding repeat	Pallas J, Coggill P	anon	Pfam-B_5998 (release 23.0)	Repeat	Streptococcal surface repeat domain - SSURE - is a protein fragment found to bind to extracellular matrix protein fibronectin but not to collagen or submaxillary mucin in Streptococci. Anti-SSURE antibodies recognised the corresponding protein on the surface of streptococcal cells. The full-length proteins are thus fibronectin-binding surface adhesins.	25.00	25.00	29.60	47.50	20.30	19.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.76	0.72	-4.39	6	697	2009-06-24 17:48:00	2009-06-24 18:48:00	3	17	253	0	24	516	0	80.90	74	34.13	CHANGED	DNGsAKNPAL.PLcG..LTKGKYFYpVsLNGNTsGKcGQALLDQlRANGo+oYpATV+VYGs.KDGKsDhsNlVATKpVsIsIN	.......DNGsAKNPALsPLtp..hTKGpYFYpVsLsGNssGKpcQALIDQhRANGTQTYpATVpVYGN.KDGKsDLsNlVATKpVTININ.......	1	6	6	12
+11800	PF11967	RecO_N		Recombination protein O N terminal	Mian N, Bateman A	anon	COGs	Domain	Recombination protein O (RecO) is involved in DNA repair and Pfam:PF00470 pathway recombination.  This domain forms a beta barrel structure.	21.00	21.00	21.10	21.30	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.43	0.72	-4.12	154	4019	2012-10-03 20:18:03	2009-06-26 14:16:15	3	8	3998	7	873	2670	1561	78.10	27	31.53	CHANGED	M....h...pspulVL+spsasEsstllslhTccpG+lssls.+Gu.+p.+..S+htu.hhpPhshlchhht......tpps.Lts.lsps-hlpsh	......................ppculVL.+sp.sa..sEsshllslhTcctG+lphl.A.+Gu...+p..t+......Sphtu..hlQPFshlphphp.........t....p.....p.....s.lps.lpps-hlp............................	0	293	578	740
+11801	PF11968	DUF3321		Putative methyltransferase (DUF3321)	Wood V, Coggill P	anon	Pfam-B_6141 (release 23.0)	Family	This family is broadly conserved, being found in fungi, plants, arthropods and up to primates. it may be a methyltransferase.	19.80	19.80	19.80	20.20	19.60	19.60	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.65	0.70	-4.72	25	219	2012-10-10 17:06:42	2009-06-26 16:42:37	3	2	191	0	159	216	23	192.80	31	60.29	CHANGED	upIcucIcphGGL-uYQhASphGQspcRGGDSSKlLVcWLpsthhphctp..p...................................L+sLElGALSspNshSpsshFc.VsRIDLNS..QpsuIhcQDFM-RPLPps-sE+FclIShSLVLNFVPsstpRG-MLpRhspFL+ssp......................t..s.LFLVLPLPCVsNSRYhspppLppIMsSLGFthspp..+popKLhYaLach...........psp........hpspha+KcplpsGss+.NNFsI	...................................................................................................t.l.tthtt.GGhptYQ.uS...up..p+t...ou+hlhphlt.......................................................................lphL-lGults..............N.hs.p.......thhp.shtIDLps..pp.tlhppDFhc................p........P....l..............s........p......t....p...............s....-.......p.................FcllshSLVLNaVPsstpRGpMh++spchLp.suh................................LFll....lPts.....C.l..p..NSRahs......pphpthhpuLGaphhp...cpss+lh.ahhach..................t...................................................................................................	0	50	81	129
+11802	PF11969	DcpS_C		Scavenger mRNA decapping enzyme C-term binding	Moxon SJ	anon	Pfam-B_9894 (release 8.0)	Family	This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.73	0.71	-3.86	99	1192	2012-10-01 23:45:21	2009-06-26 17:03:18	3	21	724	20	661	5559	3144	113.70	25	50.60	CHANGED	phla...shlhptpp..sppl....la..cD........-thlshpDhp........Pp.........ushHhLsIP.++..................cIpolpD......L.....spc.chsLLtchhphupclhppph.t..............h.ps.hphshHhtP..ohaHlHlHllu......h.sptht	.............................................................hla.s.hl...ttp.........ssph......l.a..cD................-phlshp.Dlp......Pp.......................AshH..hLllP..+.c.........................................cIto.lp.c.......L....................st.c....c.h....s....L...L.t.c.h.h..p...h..u...p...c..l.h.p..p.p.h.t............................................s..p.p...h..ph....G.h....H....h.ts.............oh.h.H.LHlHllu..............t...............................................................................	0	218	363	534
+11803	PF11970	Git3_C		G protein-coupled glucose receptor regulating Gpa2 C-term	Wood V, Coggill P	anon	Pfam-B_11657 (release 23.0)	Domain	Git3 is one of six proteins required for glucose-triggered adenylate cyclase activation, and is a G protein-coupled receptor responsible for the activation of adenylate cyclase through Gpa2 - heterotrimeric G protein alpha subunit, part of the glucose-detection pathway. Git3 contains seven predicted transmembrane domains, a third cytoplasmic loop and a cytoplasmic tail [1]. This family is the conserved C-terminal domain of the member proteins.	21.00	21.00	21.00	21.10	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.48	0.72	-4.22	19	170	2012-10-03 04:04:29	2009-06-26 17:08:30	3	3	114	0	132	185	0	74.00	30	13.66	CHANGED	+cRRppIp+Qh+uIFIYPhuYlhlWlFPhlhcshpas.ap.......h..pptPhhWlshlushhpPhsshVDshVFhhRE...+PW+h	.........t..php+lpR.l+hhhlYPluYlllhL.Plsstthths.............p.spsPshhhhhluushhshsGhVDsllaslpc...+....h......................	0	28	68	110
+11804	PF11971	CAMSAP_CH		CAMSAP CH domain	Bateman A	anon	Bateman A	Domain	This domain is the N-terminal CH domain from the CAMSAP proteins.i	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.84	0.72	-4.33	27	382	2012-10-03 10:10:54	2009-06-26 17:12:11	3	57	114	0	173	3124	9	79.90	31	5.82	CHANGED	hspscpsshhs.lcslhcDhsDGssLstllHaYpPphlplcslshppshShtcslhNlpllpphspcpL..psh.h.sh-Dllhs.	...................stpssh..t.s.tV..psLs..p.shpDGshL.C.tLlpp...Y..pPp.hl.s...L.....c...-Is.........h..+sp.h.S............h..slp.Nlphh...s..hs.ppth..p...h.p..Dhh.h...................................................	1	40	54	97
+11805	PF11972	HTH_13		HTH DNA binding domain	Fenech M	anon	Pfam-B_8688 (release 14.0)	Domain	This is a helix-turn-helix DNA binding domain.	24.20	24.20	24.20	24.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.56	0.72	-4.12	12	171	2012-10-04 14:01:12	2009-06-26 17:21:52	3	4	128	0	53	149	5	53.90	53	15.22	CHANGED	LPpLl-LlloRPlVSuuMlscpLclTspuAlpLVpELGl...REhTGRGRaRAWGll	.........LPpLhELlLppPLVSuthltKcLpVT.puAh+...L...l...sE...LsL....RElTGRGRFRAWGll......	0	7	28	39
+11806	PF11973	NQRA_SLBB		NQRA C-terminal domain	Bateman A	anon	Pfam-B_3622 (release 8.0)	Domain	This family consists of the C-terminal domain of several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NQRA) proteins.  The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration [1].	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.20	0.72	-3.63	74	761	2012-10-03 10:59:06	2009-06-26 17:24:09	3	6	729	0	165	657	475	51.30	46	11.49	CHANGED	VlALuGPpVpp..PRLlRTplGAslspLssGc..lpss.psRlISGSVLsGcpstu	.....VlALAGPpVpp..PRLlRThlGAsLsp..Lss..u-....ltsu....-......sRlISGSVLoGppup.s.....	0	44	94	137
+11807	PF11974	MG1		Alpha-2-macroglobulin MG1 domain	Bateman A	anon	PDB_2a73	Domain	This is the N-terminal MG1 domain from alpha-2-macroglobulin [1].	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.78	0.72	-3.43	168	1084	2012-10-03 16:25:20	2009-06-26 17:28:18	3	42	1060	0	261	942	44	99.60	36	5.76	CHANGED	lsslu.lt.spps.....................phhlps.ss...upshss...pVpl......hs.pps.t.........sht..psp..os......spuhhph.........................................................lph....psshshs.......phslsupss	....................lSDlG.lo.s+ph........cspl.........clFspSLcs..Gts.sGl.cVpL..ls.cpGp.............sLs..pus..oDupG+lplcss.................................cssslllA+.....c...................csphohLcL....phsuLDLu...-FsluGt..s...................................................	0	75	154	208
+11808	PF11975	Glyco_hydro_4C		Family 4 glycosyl hydrolase C-terminal domain	Mian N, Bateman A	anon	IPR001088	Domain	\N	21.90	21.90	22.80	21.90	20.90	21.60	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.45	0.70	-4.57	8	2959	2012-10-02 13:39:36	2009-06-26 17:33:48	3	5	1463	33	464	1786	410	216.50	29	50.24	CHANGED	-clclphhGlNHhsWhpclphp.GsshhspLh-tluphucss.phcs..h.tssascshh+utsh.ths..hlssoatpahhhs...cahlchphssh...........hsRsppllcchpKplhpp...........htchhKppp.hlpspcl-c+.uuhhu-tthshl...aNsccthhhlNl.NsGtIsNlPssusVEVsClls+NGspP.hhlGsLPppltu.LhcpplsspchssEAhlTtchpplapAhhhsPpV	..............................................................................................plphchhGlNHhsahppl..hc..Gps.h....h.s.....p.......Lhc...tl....t...p............t...t........................h.........s..........c...........s............hh............t...s..........h..s.............p.....s..h..l.+.........h....t....................hlP.s..s..Y.h+Yahhs.............c...h..lp.....th..tc.h...............................hsRu.....ps...l.p.........chc+p.l.h.............................................ph..h..c.s.......p.....h..t...h...p....s..p...c..l.-..t.....+....s...us..h..Y...u.c...........s..shphl...................as.s.c.t..s..h.h.h.lNl.N......p............G..........t.......IsNlP...s-ssVElsClls.tsGspP..htlG.pl..Ps.t.htG....Lhps.hshEpLsl-Ah....lstshpcshpAhshsPhs.................................	0	162	297	368
+11809	PF11976	Rad60-SLD		Ubiquitin-2 like Rad60 SUMO-like	Wood V, Chahwan C, Coggill P	anon	Wood V, Chahwan C	Family	The small ubiquitin-related modifier SUMO-1 is a Ub/Ubl family member, and although SUMO-1 shares structural similarity to Ub, SUMO's cellular functions remain distinct insomuch as SUMO modification alters protein function through changes in activity, cellular localisation, or by protecting substrates from ubiquitination [1]. Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). Despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9)), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. Structural analysis of PDB:2uyz reveals a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating SUMOylation [2]. The Rad60 branch of this family is also known as RENi (Rad60-Esc2-Nip45), and biologically it should be two distinct families SUMO and RENi (Rad60-Esc2-Nip45).	23.70	23.70	23.70	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-4.29	42	1068	2012-10-03 10:59:06	2009-06-26 17:36:11	3	36	345	50	689	8130	273	69.50	32	32.96	CHANGED	lplhl+stssc..clthclctsoplpcLh.ptappcpslst.....pplcLlFDGcplpsspThp-hslcDsDh..l-lll	................................................................plpVt.s..p.-ss...pl.p.F..+.l...K..c....s....T......Lp...KLh...cu....Ys......c....+.....p...G...l..sh..................psl+Fh...F.D........G..p......p.l......s....t...s....p...T.P...ppL.-.ME.D.t.Dh..I-V...............................	1	230	363	528
+11810	PF11977	RNase_Zc3h12a		Zc3h12a-like Ribonuclease NYN domain	Bateman A	anon	[1]	Domain	This domain is found in the Zc3h12a protein which has shown to be a ribonuclease that controls the stability of a set of inflammatory genes [1]. It has been suggested that this domain belongs to the PIN domain superfamily [1]. This domain has also been identified as part  of the NYN domain family [2].	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.90	0.71	-4.39	28	659	2012-10-03 20:43:45	2009-06-29 14:20:43	3	19	191	6	414	616	25	146.30	36	23.62	CHANGED	phRhlVIDGSNV.Ah......sH......sppch......FSs+Glthslpa..FhpRGHcslslFlspa..phpt...................ssthp-pchLpcLhc....tshlshsP.....Spph.Gpp..saDDRaILchApcpcGllV.SNDpaRDlhp.......cpsch+chlcp..........................RlLhaoFs.........tDthh.ssD.PhGRpGssLpc	............................................................................s.h+.lVIDGSNV..Ah.................sH............Gppch.......................FSs.+.GItlAVpa...Fh.c..+....G..+.p.s...l..s..VFlPpa..Rpcp...........................................ss..hs-..pchLp...cLpc....ptl..Lsh...TP..........o+ps.G.pc..hs..s.aDD.Ral..l..clA..h.c..s..c............G..lIV.SNDpaRDhhs..........-pspa..+.....c.....hlcc...........................RLL.aoFs....................sshFM.PcD...PhGR.GPpLp.p..................................................................	1	101	165	282
+11811	PF11978	MVP_shoulder		Shoulder domain	Bateman A	anon	Bateman A	Domain	This domain is found in the Major Vault Protein and has been called the shoulder domain [1]. This family includes two bacterial proteins Swiss:A6FXE2 and Swiss:A1ZGE7. This suggests that some bacteria may possess vault particles.	25.00	25.00	25.50	30.60	22.90	21.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.49	0.71	-4.21	20	152	2012-10-01 22:02:33	2009-07-05 15:15:55	3	8	82	41	76	140	4	117.60	58	14.85	CHANGED	GPDFhTDllpVETuDHARLpLpLuYNWaF-V.stsc.t...tsp+hFoVsDFVGDuCKsIASRlRuAVAuhsFDcFH+NSu+lIRpAVFGhcpt..........Gps+...spLpFssNsLVlTsVDlQSVEPVD	.........GPDFhTDlIslETuDHARLpLpLuYNWaF-l..spp.csp...psu+LFSVPDFVGDACKAIASRVRGAVASlsFD-FHKNSu+IIRsAVFGh-ps..........scsR...cphhFstNsLVloSVDlQSVEPVD.............	0	41	49	61
+11812	PF11979	DUF3480		Domain of unknown function (DUF3480)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2031 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 350 to 362 amino acids in length. This domain is found associated with Pfam:PF01363.	25.00	25.00	29.40	28.90	19.40	23.10	hmmbuild  -o /dev/null HMM SEED	356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.16	0.70	-5.83	8	179	2009-07-05 15:08:20	2009-07-05 16:08:20	3	9	82	0	101	161	0	292.60	50	28.68	CHANGED	slPssPYLhGlLIpRhEVPWAKlFPLRLMLRLGApYRYYPCPLhSVRtRcslYGEIGpTIhNLLsDFRNYpYolPsVpGLlIHhEsp+ToIpIPpsRYs-lhKslNsS.s-HlLAhGusF...ochADuHLVClQN.-u......pYpTQAIsIcsQPRKVTG...ASFhVhsGuLKoSSGhhAKsSIVEDGLMVQIsPEpMptLRpALRsMKDapIsCG.l......-usDsQ.EhVsIpWV-s-pshNhG..VlSPIDs+uh-GlsSh+l..apuo-Ypsss.+IIRWTEVFhlps--c.pstsusstshoRLuEplA+usCtALsPHLcLLtpsGhsKLGLRlolDo-pVuYpAGSpGp.LPspYhNsLDstLlPll	...........................................lPssPaLhGlLIp+hEhPWAKVhPhR...LhLRLGAcY+.hYPsPLhSlRhRcslaG.EhGc.T.IhNlLsDhRNYpYoL.slptLhlchE.tposI.p.IPpp+as-h...............h.Ks.hNpS.N-HVluhGAsF...spcADSHLVClQN.sG........................sYpTQA.S..h.pspPRK.VTG..............ASFhVFsGALKoSSGalAKSSIVE...DGlMVQIssE..sM-uLRpALR-..KDFp.IsCG+s........Dut-.....p..Ehl.pIpWVDs.-.cp.hN.t..G..VhSsIDGpSh.....-.....u.....lssh+l......ht...ts.-a..c.s.s..t..+hlRhTEV..Fahtp-....pp.....hu......ssttphscplApAhshALsPHLchL+psGhsKlGLRVolD.oDp.VtapAGS..pGp.LPtpYh...NsLDssLlPVl...................................................	0	22	32	63
+11813	PF11980	DUF3481		Domain of unknown function (DUF3481)	Assefa S, Coggill PC, Bateman A	anon	Pfam-B_2819 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 80 amino acids in length.  This domain is found associated with Pfam:PF00754, Pfam:PF00431, Pfam:PF00629. This domain has two completely conserved residues (Y and E) that may be functionally important.	28.50	28.50	35.10	48.00	25.10	24.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.08	0.72	-4.16	6	219	2009-09-16 09:17:33	2009-07-05 16:10:11	3	9	43	0	64	168	0	83.80	51	9.77	CHANGED	-sos-T.lShpPsshLhoLDPILlTIIAMSulGVLLGAVC.GVVLYCsCh+suhocRs..hSsL.............ENYN......................FELsDGlKLKK-.hssQssh	...............t.............ps........LDPILlTIIAMSuLGVLLGAlC.GllLYCsCtasGhSpRs....hosL.............ENYN......................FELhDGlKhKhc.hNpQpsh........	0	2	8	23
+11814	PF11981	DUF3482		Domain of unknown function (DUF3482)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3168 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is typically between 289 to 301 amino acids in length. This domain is found associated with Pfam:PF01926. THe central region of these proteins contains a hydrophobic region that is similar to Pfam:PF05433.	26.40	26.40	26.40	27.20	25.40	26.30	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.61	0.70	-5.18	27	234	2009-07-05 15:13:17	2009-07-05 16:13:17	3	4	229	0	64	219	15	277.10	36	60.69	CHANGED	RcALAchsLHAhhp..FDoVAssh-sEt+LacslutLLcp.tps.LpcLlsspppptptRpptAsplIA-LLl-sAuhR..tplssptst....ppshpphppplRppEppshcsLLpLYpFcppDhpsscLPLhsttatpDLFsP-sL+thGlchus....GuAuGAusGsGlDLhsGGlTLGsuAslGAlsGGs.......hpsspphup.cl......huKl.......pGp.+cLsl....DsssLpLLhlRphpLlsuLppRGHAupcslpLts..sp....p..............pth.....cp..spLschLpcA....Rs+PpWSsLs.....................st..chtptpRpphlppLsspl	..................................................................................................................phLuRhsL.HshstFDoVA.sh-GEh+LacsLAhlL..p.hc.stLcRLhstpppphpphpppAtchIA-hLlDsAAhR..........pplspstsst..............................pshpphppplRphEpph...ptLhtLYpFhcs-hsssc..hhsttatpD.hFssEhL+phGl+hGs..........GsAsGAhhGhGl....DlhshGsoLG.hushlGulhGGh........h.ssps.......l..hsKl.............pGt.ppLps.....DstsLpLLAhRth.pLltsLppRGHAAps.slcLps...p...............tsW.............pt..s+LPp.Lp+A.Ru+..pWS.oLs.....................st...c.pptcRtthhptL....hh...........................................................................................	0	19	35	56
+11815	PF11982	DUF3483		Domain of unknown function (DUF3483)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3204 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 230 amino acids in length. This domain is found associated with Pfam:PF02754.	26.80	26.80	27.40	43.00	23.40	26.70	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.62	0.70	-5.05	14	145	2009-07-05 15:16:29	2009-07-05 16:16:29	3	4	143	0	52	139	9	221.60	55	35.17	CHANGED	hLstlLPhLlahuLuLsslGAsRRsthWRpGpsopVsalu..GLhAhP+RYLVDLHHVVtRD+YhS+THVATAGGhVluhsLslLsashuLtsp.....hLsahLLsAshs.MhlGulFVupRRh...sPPuRLS+GPW.RLP+SLhuFuluhhlsoLssA.G.hlssshGGWsLsslLuhul.hhGssEhhhGhshGGPMKHAhAGALHLAaH.RsERF...........sGGRSTuLKslDLs......ss.L	.......shLlssLLahulAhhshuss+RsshWRhGRuopsshhG..sLhAhPKRYhVDLHHVVARD.YlA+THVATAGGhluAhsLshlsaGhulau......hLshhlLlAshs.MhVGAlFVa+RRh.....ssPARLS+GPW.pLPh.LhAFAluhhLhsLssA..G.....t....h.G.....uaslhshLhlGl..GshphhhGhshGGPMKHAhAGhLHLAaH.RtERF...........uus..sTuLKs.DLpc...h.....	0	11	23	37
+11816	PF11983	DUF3484		Domain of unknown function (DUF3484)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3216 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 65 to 81 amino acids in length. This domain is found associated with Pfam:PF02491.	27.40	27.40	27.40	27.80	27.00	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.35	0.72	-3.14	15	535	2009-07-05 15:18:48	2009-07-05 16:18:48	3	4	530	0	32	179	0	75.30	36	16.84	CHANGED	V-hLAQtAVsG-phlc++P.s...........phcpsssstpsss.ppPtppsstsppp...........spcscpcls-Rl+uhFGshFD	....................VshLAQsAl+GEpsLp+QPlsh............hs.pa.spss.sspss.s..s...-.t.....s..hts.scs.s-................tsspsKsKls-RhRulhGsMFD.	0	3	11	20
+11817	PF11984	DUF3485		Protein of unknown function (DUF3485)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3236 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 223 to 526 amino acids in length. This protein is found associated with Pfam:PF09721.	26.10	26.10	27.60	26.10	25.90	25.70	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.23	0.70	-11.15	0.70	-5.24	59	191	2009-07-05 15:21:24	2009-07-05 16:21:24	3	2	160	0	96	206	48	204.30	17	52.21	CHANGED	thhhssslllh..hussshhhp.t......ptssssppshthhPtp.husWptssss............stht.phhsssphlh.ppY..tssp.....spsVsLaluYapsQ...pssphlHpPps.Ch...sus..GWphhspp..ptslshsst...shplschhhptts.....ppphlhYWathssph.h......ssshps........KhhthhstLhspts...Duull+lsss............ppsstsAtptlppFl.pphhsslsthl.	...............................................................hh...hhhhhhlh...hsshshhhtst.........tt...thss....tp.......ht.thPtp.husWpttstsh...........stht.phhsssphlt.psY......tsss........sptVsLalu..aapsQ...ptspt.lHsPps.Ch.....sus...GWphhspp..tt.s..lshsst.......thplschhhpt....ss.......ppphlhaWathsu.ch..h......ssthtt...........Khh.hhstlttpts...-ushlplss.............tts.ttu.thhppFh.pphhs.l.............................................................	0	36	81	91
+11818	PF11985	DUF3486		Protein of unknown function (DUF3486)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3271 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are about 190 amino acids in length.	25.00	25.00	25.90	25.00	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.95	0.71	-4.22	34	265	2009-07-05 15:23:11	2009-07-05 16:23:11	3	2	219	0	56	231	5	173.50	25	95.02	CHANGED	Ms++SpV-hLPts...lRphLpphLpspshothclLppl.phh.t.......sh..........plS+SulpRYup+hEphhtpl+pupEhAchhspphu-.spschuchlhphlpohhFcshhsht-stcpp........hchLsplApslsplppAustpc+hpt-lRpphttpsss........ts-phsppsGl......Ss-shspIRcplL...G	.............................huRtSpl-.hLPp...s....l+p...hLpphLp-pshoth......c.hl.ppl.phh...................sh.......plS+SulsRY...up.......+h....-p....hhtpl+pspEh...uchhspphu.-...spscho.chlhphlps.hacthhphpEstpss..............thlsplutsh.tpL...ppAuh.tpc+hcp-.....l.......+tphttthsp.........s-ch....s...tp..sGh......ot-hhptl+p.lLG.......................................................	0	24	45	51
+11819	PF11986	PB1-F2		Influenza A Proapoptotic protein	Mistry J, Gavin OL	anon	pdb_2hn8	Domain	PB1-F2 is a protein found in almost all known strains of Influenza A virus - a negative sense ssRNA Orthomyxovirus [1]. It originates from translation of the viral polymerase gene in an alternative reading frame [1]. PB1-F2 consists of two independent structural domains, two closely neighboring short helices at the N terminus, and an extended C-terminal helix [1].  Although the protein has originally been described to induce apoptosis, it has now been shown that PB1-F2 more likely acts as an apoptosis promoter in concert with other apoptosis-inducing agents [1]. PB1-F2 promotes apoptosis by localising to the mitochondria where it destabilises the membrane. This will cause release of cytochrome C which activates the caspase cascade of apoptosis through the endogenous pathway [1]. In this way it acts like the Bcl-2 protein family which are physiological apoptotic regulators in cells [1].	19.50	19.50	19.50	24.30	19.30	19.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.24	0.72	-3.95	24	10057	2009-07-06 12:30:56	2009-07-06 13:30:56	3	1	10020	2	0	3113	0	83.60	71	99.95	CHANGED	MEQEQDTPWTQSTEHINIQKRtsGQQTQ+LEHPNSTQLMDHYL+TMsQVsMHKQTVsWKQWLSLKNPTQsSLKTRVLKRWKLFsKQEWTN	.MEQEQsTPWTQSTEHhNIQKRGsGQQhQ+LEHPNSTQLMDHYLRhMSQVDMHKQTVsW+.WhSLKsPTQtSL+T+sLKpWK.FNKQtWTN.	0	0	0	0
+11820	PF11987	IF-2		Translation-initiation factor 2	Mistry J, Gavin OL	anon	pdb_1z9b	Domain	IF-2 is a translation initiator in each of the three main phylogenetic domains (Eukaryotes [1], Bacteria [2] and Archaea [3]). IF2 interacts with formylmethionine-tRNA, GTP, IF1, IF3 and both ribosomal subunits [2]. Through these interactions, IF2 promotes the binding of the initiator tRNA to the A site in the smaller ribosomal subunit and catalyses the hydrolysis of GTP following initiation-complex formation [2].	20.20	20.20	21.20	20.30	19.20	20.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.32	0.72	-4.18	243	5391	2009-07-06 13:34:25	2009-07-06 14:34:25	3	51	4886	6	1587	4288	2608	108.80	42	13.02	CHANGED	s.....oL-shhsphp...pu..p...hcpLslIlKADVQGSlEAlpsuLpKls..s--VclpllcuGVGuIoEoDVtLAsA.S..s......AlIlGFNVRssspA.+chA-pcs...V-IRhYslIYcll--l+t	......................................spL-shhpphp.....pG..-.....hcp..lslllKADV.QG.SlEAlpsSLtKls......s..-....-.............V....+V....pllcuuVGuIoEoDls.LAsA.S.s............AlIlGF.NV.R.s..s.s..p.A.+c...h.A...-......p....-s......V-lRhYslIYclI--lc........................................................	0	547	1002	1339
+11821	PF11988	Dsl1_N		Retrograde transport protein Dsl1 N terminal	Mistry J, Gavin OL	anon	pdb_3etu	Domain	Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum [1]. It is localised to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles [2]. It is comprised primarily of alpha helical bundles [1]. It complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein [1].  A central disorganised region between the N and C termini of Dsl1 contains binding sites for coatomer [1]. The C terminus of Dsl1 contains a binding site to the Sec39 subunit of the Dsl1p complex [1].	25.00	25.00	43.40	43.20	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	354	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.97	0.70	-5.58	7	25	2009-07-06 14:57:28	2009-07-06 15:57:28	3	2	24	3	13	24	2	341.10	49	47.20	CHANGED	plhsspspllptltpDP.lh.csss+.psp.....hDhpslLpp-spLsc-LptLppLKhlusLlhEapsNh-lhELENCYYSLQNL+KKh+ssss.htpuhpFQQSlsoalDsLHlpLls+lhcllsphFWpIstsohpFppplphtcDcsp...h-Y-shhpFlppsaFscshlD.ppWhItshshu-.p-pVpppLsoIhpsYlphsplhctlKphlFscphphohps....p+LplspS...Gt.hlscplpSatsLssFl.sslo.cDpttlhhcLGsslssEhhKhlKpNupplLpppss.hKp.ls.lN-pLppLSpcot..sWsYsGp-lpcLLNDcplapsLhLDplhpppl.cIR	..u.LhsNKsEIIcpLhKD....PLll.cs-o+..coNt............phcLDss-LLpREuhLusELphLssLKTh.sLIcEhKTNlplLELENCYYSLQSLRKKh......R..N.NuuaL.KQSFsFQQSluTYVDTLHL-LVooLYcILTstFW+ITEN.SIpFsPoVEaG+D...+V+...IEYDTFM-FVsQQYF..PcGsLDspuWFIhDMs.uDuQEpVRuKLNTIhK-YhsLSpllshIKsuIFhsG+cISYEs..ppshLlFuKS..SS..+GpcslossLsSFcuVsDFhLDsLuh+D++oLuhcLGPLhsTEFTKFVKsNASlILcshc.SPLKsLVSsINsKLs+......Lsu+Sc...sosWoauGcEIpDLLhNKplYaNLLLDKlLEuHIo-IR.	0	1	6	12
+11822	PF11989	Dsl1_C		Retrograde transport protein Dsl1 C terminal	Mistry J, Gavin OL	anon	Manual	Domain	Dsl1 is a peripheral membrane protein required for transport between the Golgi and the endoplasmic reticulum [1]. It is localised to the ER membrane, and in vitro it specifically binds to coatomer, the major component of the protein coat of COPI vesicles [2]. Binding sites for coatomer are found on a disorganised region between the C and N termini of Dsl1 [1]. The C terminal domain is involved in binding to the Sec39 subunit of the Dsl1p complex [1]. The N terminal complexes with another subunit of the Dsl1p complex called Tip20 which forms heterodimers by pairing the N termini of each protein [1].	30.00	30.00	30.30	30.50	29.70	29.90	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.78	0.70	-5.25	5	58	2009-07-06 15:01:51	2009-07-06 16:01:51	3	4	55	1	39	61	0	287.90	29	38.41	CHANGED	DGWDEEWDID..ID-lcppsspt...........p-cIpITpLPctFtpIhpcFEpuscslucupV-spYhtYKFNLLQTuFFAMsosKasN-WaQLYpDMRYlhoc..NscLhRLpELstRhhEsNLshp+KhVppllpcQLspL+cNE+sPsWDsTIcsLLPFIccEllssLp+Itt.-up+aLLsFLsFLaNDCllsNILpWcIISEKNSENLSELIpLllNuT-IsuLsspPcYR+hREKluIluKlLPLHLKDIMEMFYNGDFYLFuTEEIIQWIlLLFADTPLRRDAIDDIpEIRpEupD	....................................................................................sWs-..s.Ws.-......h-.ctt.pptppt........................t...ppplplTplPp.hhtl.ppap...p..sh.sp..s....t.hp.p..p....h.h......ths.......l..L..t..o..hhAh....sps........pa..s....p..s...h.LasDhpYlhp..c......spp..L.chp.......-hs....h......p.h....lp.............pphp.phchV..h........pl..lpt..p..hp.p.hp...c.s........-cp..s...sh..ct.shppl...l.shl.h..ppl....h.p....h...ppl.pt...ppt.....phlhp.hlshl..hNshllppIlphp.ISEhpSppL.......ucLls.......ll..h..s.........s..o..c..l....t..tL..s....p...ps....s....Yh...c...s..hpKFshltplLssHLK-IM-hFYpG-ha..FuT-ELlphIchLFA-osLRcssIs-Ih-hRt...........	0	10	22	38
+11823	PF11990	DUF3487		Protein of unknown function (DUF3487)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2242 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 121 to 136 amino acids in length. This protein has a conserved RLN sequence motif.	25.00	25.00	29.00	28.80	23.90	22.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.62	0.71	-4.72	25	230	2009-07-06 16:44:55	2009-07-06 17:44:55	3	2	188	0	64	200	9	119.40	36	94.45	CHANGED	-sTlsFLP..cRLNp-PlVhRGhTssEhhlssshuhshG.lllGlsLuhl..suhlt..hlPshhllsslhslhlGushLpRlKRGRP-saLaRp.lph+lstph......lGsppLIh+SGhWolRRo....................tpt	..............tTlpFLPpRLNpcPl.Vh+GLTssEh.hlsshh.us.ssG.hllGlP.luhl..hs..h.h.h.hhPss...s..llsshlslhlGu....th..LpRl...KRG+P-saLaRp.Lp.h.p...lsphh.........lGsppLIh..+SGsWohRRo........tp..................	0	7	28	51
+11824	PF11991	Trp_DMAT		Tryptophan dimethylallyltransferase	Assefa S, Bateman A	anon	PFAM-B_2054 (release 23.0)	Family	This family of proteins represents tryptophan dimethylallyltransferase (EC:2.5.1.34), which catalyses the first step of ergot alkaloid biosynthesis [1]. Ergot alkaloids, which are produced by endophyte fungi, can enhance plant host fitness, but also cause livestock toxicosis to host plants. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 390 to 465 amino acids in length.	25.00	25.00	28.60	25.50	23.80	22.30	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.41	0.70	-12.09	0.70	-5.24	53	313	2009-07-06 17:00:22	2009-07-06 18:00:22	3	10	118	12	161	321	0	311.10	24	78.37	CHANGED	t-pch..WWcpouPhluplLpsAs.YslcpQapaLthapphllPhLGPaP.........ttttpahShl...optGhPlEhShNa........ppstp.sVRhshEPls...hsGTs.tDPhN.ptustchlpcLsph.hssl.DlphacaFtpplslspp..-pttlpppt..................h+s.....pthluhDLc....sup..hslKsYh......hPthKuhsoG.h.ssppllhcul+pls.t......thtsuhphlcsalssps........................sthpsth.luhDh.lsPs...coRlKlYltp.p.sohsplc-laTL.GGRhs..s.ssshcGLc.hl+cLW.pllsl..........sh......................ps.thstss..stphs.......hhhsa-l.pP........Gp.shPp.......splYlPl.h..............uhsDttlApuLspF.acphG..apchApp.YtssL	........................................t.Wh.ptsushhsphhttus.Ys.ptQhphLhhhtphl....lPhLGshP............tt..hahShl...ottusPhEhShsh.............spst..hlRhshEPls..hsG..st..tDshN.ptshtphlppltt................ssh...chphapthtpplhlstp...ptthh.tt...................hhs...............p.hluhDhp.......ssp........hshKsYh...........hPth+uhssu.............s.......tplh...hpulcpl.........thtsuhphlppahtpts...............................ththth..luhDh.lsss...........coRlKlY.hhpt..p.sshsplpchhTL.GGRh.p....s....ts.culp..hlcplW.tlhsh.....t........................t.....htt..t.ths..........hhhsapl.ps........sp..hPp........splYhssh..............s.sDhtlspslspahpphG..ht.t.sp..Y...............................................................................	0	28	75	132
+11825	PF11992	DUF3488		Domain of unknown function (DUF3488)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3123 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 323 to 339 amino acids in length. This domain is found associated with Pfam:PF01841. This domain has a conserved PLW sequence motif. This domain contains 6 transmembrane helices.	25.00	25.00	25.10	25.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.05	0.70	-5.79	60	397	2009-07-06 17:02:56	2009-07-06 18:02:56	3	6	379	0	159	408	140	317.90	25	47.85	CHANGED	ptlsR..psh..ha.LL.hshshllhPhhtplPhWhsu...lsshsllWRshlhhtph............sh...PsR....................allsslsls...ussslhhshsp.hhuh-sslsLLllhhuLKhlEh+spRDshlllhLuaFllhssFlhsQulhhshhhllslhhlhsuLlsl....pt.stsp.......................h..tpsh+huuplhL.ulPLhllLFllFPRl.sPLWtlP.sstsupTGLSDsMsPGsIupLspSsplAFRs.pFsus............P..spspLYWRGhVLppaDGcsWpts...........tttthtss.stsss.................t.tupslc...YplhhEPopppWLauL-......hshsss....sssths..sDhp.hhsp+P..lspph+YpspShsph	.........................................t.........h..hh.lL..hshhhsl.hPh....h.hplPh...hh...hs...lh.s.h...shhhp.h.h.h.hht.ph.............h..P.sp....................hl.h.shlhls...shhsl...h...hp..h.ss..h.......h.......u...h-susslLlhhhsLK...hlEh+st.RDhhhllhlu.h..FhlssshlhsQu.....h....hhshhhl....ls..l....hh..hhss..L.l..tL.......pt..sptp.....................................................h...ttsh+h.ust.lhhhu.l.P.L...hl...lLFlhhPRl...s.....PL.Ws.l........P.......s.s........s...p.....u.p...T..G.LSD.p..hsPGslupLspssplAFRs.pF.sss...............P..s.p........ph.....YWRuhVhppa...D.....G.p.pWpts...................................thts..sts.p....................................................tspslp...Yplh..hEPs.p.ppa....LhuL-........hshsts........ts..s..tht.....s-hp.lhtpps..lsp.h.hpYphpSh......................................................................................	0	48	110	140
+11826	PF11993	Ribosomal_S4Pg		Ribosomal S4P (gammaproteobacterial)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3290 (release 23.0)	Family	This family of proteins are ribosomal SSU S4 p proteins. This protein is found in gamma-proteobacteria. Proteins in this family are typically between 162 to 178 amino acids in length.	25.00	25.00	28.70	33.10	19.60	24.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.91	0.71	-4.47	19	166	2009-07-06 17:08:16	2009-07-06 18:08:16	3	1	165	0	38	120	7	163.90	44	97.59	CHANGED	MQlcslt...LINEhQhGspLNpAVcpuRRu-.FuLlLuMLSpDsRDhs.hch.pstps.......pcptLRppFpls...psQsLtustsshphustpAphap....ptGhsuh+LpptLsPEsLshpsp-stsls-plhpNhShpsR++ltsp............pshphs.tphYspLssspptsplttp	........................................MQlHTLDKAslIsElphGpulspAV.pc..GRRAD.FALLLuhhSsDVRDsoPl-plcssss.......oEpsLRpcFELu...pPQ.tLcsDpSSYpluAcQAslFH.........puGhsSAKLuHYLpPEsLsaRPpDTpsLPEEVYtNLSGHpRR+Lus+............psspl.stchYcpLssAhRpsplps.t.......................	0	6	14	26
+11827	PF11994	DUF3489		Protein of unknown function (DUF3489)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3545 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 84 to 211 amino acids in length. This protein has a single completely conserved residue W that may be functionally important.	28.30	28.30	29.20	30.50	28.20	27.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.47	0.72	-4.03	26	127	2009-09-11 08:24:30	2009-07-07 12:41:14	3	4	70	0	54	132	26	73.80	42	46.18	CHANGED	scsspsRp...................soKQsplIshLp+PcGA...TlspIscsTGWQsHTlRGsluGsl+KKLGLslso-Kss...u.sph..YRIs	............................................tsRt................soKQAplIsMLp+PpGA...TlspIspATGWQsHTVRGshuGshKKKL...GLslsScKss.......uttRs..YRI.................................	0	20	40	48
+11828	PF11995	DUF3490		Domain of unknown function (DUF3490)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3558 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF00225. This domain is found associated with Pfam:PF00225. This domain has two conserved sequence motifs: EVE and ESA.	25.00	25.00	31.50	28.70	24.40	23.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.13	0.71	-4.68	12	129	2009-07-07 11:50:29	2009-07-07 12:50:29	3	9	24	0	81	127	0	153.30	50	17.22	CHANGED	-Fc+QpppII-LWpsCpVSLlHRTYFaLLF+GD.uDpIYhEVELRRLoaL+pohupss....A..ss.pslolsSSlKALpREREhLuKhhsp+hotEER-pLYhKWGlsLsoK.+RRLQlsp+LW.osspDhpHVcESAslVAKLlGFsEsGpts.KEMFsL.................sFss.s	.............pFc+pppcII-LWcsCpVSllHRTYFFLLF+GDsuDsIYMEVELRRLoaL+poaupss............tsh...ss..sh.....ohsSSh+sLpRER-hLu+pMp++LotE.EREpLYhKWGlsLsoK.pR+LQlsp+LW.ocspDhpHlcESAslVAKLlGahEsGps..KEMFuL.sFss.s..................	0	9	48	65
+11829	PF11996	DUF3491		Protein of unknown function (DUF3491)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3393 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 286 to 3225 amino acids in length. This protein is found associated with Pfam:PF04488. This protein is found associated with Pfam:PF04488.	25.00	25.00	25.50	25.40	24.20	23.60	hmmbuild  -o /dev/null HMM SEED	936	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.47	0.70	-7.05	8	259	2009-07-07 11:54:01	2009-07-07 12:54:01	3	4	123	0	7	238	0	528.00	32	36.34	CHANGED	AVh-ssSRaacPPLospNcpuTVIAGcoPLTVIPlRLL---osERlcpAhuYKDYKIplpGGpGGLTVQIGGAGaYslTusP.uscNsISFRAIPtsFuVsFsLS.+tpQsVPLh+PNG.TclplLKIpQKGFsTIlGSuuGpDpLTGN.+DT+FYlSoGGGslaSGuGpNpYaIP+.LpssLsIsLosNSssHplhLs.po....hEh+ssussLoLI..h.thtsssIal.shDspsphspasssFpV+hsDGITlpAlc+tsst...........spLuVpoCD.ptWptpaPEEsuas-sIlcaL+chsWhLAPcVplhtpcupssYhshp+pLVYp.Pc.aSElplpupcsYpTtVpGssGsoYIl.s..sssspspslcIhLA-DsspPQTlDLSsllPoLVpG+hss....ssSIsLpl..SSs+YslsLolSWpscs..lPppThlplpPpcphpLG-ha+hL..ppssupWssLa+suhlIPcch.slLSlNNTshLMls+spps..sEHlLulENpuslshKlhGpLhSGaIKGu.....Wcs.spshsslp+hsloIPsHshpYLsFcGc.......cNlLF+ShLcutsLcs+spsphplS++pWppYD-IpVp....AToLpLpcFpRYpIuotscsLSRpLMYAQshVpIssRDlslKLFYl.REssGIGAlRLlFKNFFpESM-shscpTLEKEsKPlLsusPcphIssuY+sHLclhLG-cpLNLAplVpEFusop+IlshpcDhssHtllh.psppspsLsllTaTlssps-ssptt.p.p.hahDsh.pcY+.LPhsThs-s.YYLsPsoGDLYlTplls..scspsQAFll+LKsaKppWtcapphllSusHpphpp.l..ssTsLpFsGPElp+hEIDaspsss.h.h.sscllShSshlF.ss-QVlpYsP+hupQFaSh.-YMLW-L+-Rsptupc......A+saDsYLh-ushphhc+NspWKIssslLcaAlG.YYR	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1	1	5
+11830	PF11997	DUF3492		Domain of unknown function (DUF3492)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2107 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 259 to 282 amino acids in length. This domain is found associated with Pfam:PF00534. This domain has two conserved sequence motifs: GGVS and EHGIY.	23.30	23.30	23.40	23.40	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.73	0.70	-4.85	39	322	2012-10-03 16:42:30	2009-07-07 16:23:34	3	7	290	0	121	316	12	260.00	28	41.01	CHANGED	s-lsLllEGTYPYVpGGVSoWlcplIpshP-hpFsllhlGuptcchtphpYplPsNVsclcphaLhst.........t..............tppup..ppshpthcplpchhcpsst.......stthhpph......hhtltpss..shs.psFLtScps.......WchlschYpcht.....spsSFsDaFWolR.hhtPLhtl..lupsl.PtsclaHslSTGYAGhLGulhptppspPhlLTEHGIYT+ERcl-lhpupWI...............hshhRchWl+aFctlu+hsYptA-pIluLactNRphQlptGAss-	............................................................................hclsLlhEGoYPYVpGGVSuWspplIpu.hs-hcFslhhluuptpp.s.phtYplPsNVsclcphhL.st..............................................tpttpptthphhpphhphhpp.hts...................stt.h..pt.h......h.tLtptt..thshtshL.tScph..........................ac..hl..pc.....hhpphh.....................spssFs-...haWsh...Rp..hht..sl.h.l..................lspsl..Pps..clhHulSTGYAGllGshhp.t.ppstPhllTEHG.....I.....YsRERch-lhpupWl......................shh+phWlpaFttluchsYptAc.lhsLap.t.spthQhphGAs........................................................................	0	35	73	104
+11831	PF11998	DUF3493		Protein of unknown function (DUF3493)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3788 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 79 to 331 amino acids in length.	25.00	25.00	25.20	25.40	24.00	24.50	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.27	0.72	-4.09	21	125	2009-07-07 15:28:10	2009-07-07 16:28:10	3	7	83	0	70	127	107	77.70	35	29.61	CHANGED	hssptcs+LhsEspsPaRGLR+hlalAhuASuslGhhlhhhRlhu.......Gssl.tslsNLulQlGuluLhshLhhhEpp	.....h...pptt+LhuEspuPaRulRpFhYlAFsASuslGshlhls+Llu............ussl.....pslsNhulplGulslhshLahh-pp........	0	22	52	66
+11832	PF11999	DUF3494		Protein of unknown function (DUF3494)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3080 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 243 to 678 amino acids in length. This protein has a single completely conserved residue G that may be functionally important.	25.00	25.00	25.80	25.80	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.50	0.71	-4.69	43	181	2009-07-07 15:31:23	2009-07-07 16:31:23	3	33	84	5	76	193	13	198.30	33	42.53	CHANGED	lLutoul.TssGs..osls.Gsl.GsSP.susu..lsGFs....hss..............Gslasssh.............shspAhsDhtsAYs...........sAsups.ssshstl..ssGsl.uGhTLsP....GlY.....ch.suu...lslos.slTLDutG....sssuVaIFQlu...usLosu.uuu.......plhLs....sGApApNlFW......Vuuu..solGssosFpGsllups...u.Iol....sTG.....uols.GRhLAps..AVTLsssslsp	...............................................................hLutsul.ossss....osls.Gsl.GsSP..uou..lTGFs...shss...........................................sGplauush....................hhspAhsDhtsAYs...........sAAups.......s............s.s..httl......ssGpl..GGhT......LsP....G..lY.....ph..ssu...lslou..slTlDutG......ssssVaIhQhu...usLssu.uus.......pVhLs......sGAp.ApNlFW......pVuuu....solG...s...suphpGslLuts....u.lshsTG..........uo.ls.GRhLups..AVTLssssl..t........................	0	20	68	75
+11833	PF12000	Glyco_trans_4_3	DUF3495;	Gkycosyl transferase family 4 group	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3335 (release 23.0)	Family	This domain is found associated with Pfam:PF00534.	25.00	25.00	25.10	27.10	24.50	22.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.98	0.71	-4.63	53	208	2012-10-03 16:42:30	2009-07-07 16:34:35	3	4	180	0	79	213	126	168.00	33	40.39	CHANGED	ppGHclshls.tpsptshs.....GVcllpYps..pctsstssas.ahpshEspsh+GpushcusppL+pp.GapPDlIluHsGWGEsLFL+-laPcupllsYhEa.aYpspGs.DssFD..PEa....sss...psth+........lRh+Nhs.hhphppuDhuloPTpW.......QpupFPs.a+s+IpVlHDGlDTsthp	..........................................t..upclshls.ppsptth.......GVphltYps...scts...sspsa....hhpshEptsh+GpushcsstpL+pp.GFtPDlIluHsGWGEsLFl+-laPcs.llsYhEa.aYcspGs.DssFD..P-h....shs..pshhp........lRh+Nss.llslpt....sD.hGloPTpW.......Q+spaPs.h+.s.+IsVlH-GlDTshh.t...	0	17	57	68
+11834	PF12001	DUF3496		Domain of unknown function (DUF3496)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3407 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 110 amino acids in length.	30.70	30.70	30.90	30.90	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.24	0.72	-3.81	7	174	2009-07-07 15:42:55	2009-07-07 16:42:55	3	17	36	0	67	132	0	100.90	43	13.79	CHANGED	h+oQMELpIKDLESchu+hKTuQtDhspoELEcYKpLYl-ElKlRcSL..SscLsKosE+LAElsTKLhlE+cQ..scShhoohsTRPslEsPCVusLp.shshNRhhIPR...-slhl	....................psphELplKDLEscl.S+hK......T......upc-s.............poE.LEcYKphahcELKsppSL..SpKLs...K..o..sc+lA-lsTKLLhEKpp..p+shhoolssRPs.Es.PsVtNLs.ShslsRphhP+t..................................	0	8	10	19
+11835	PF12002	MgsA_C		MgsA AAA+ ATPase C terminal	Mistry J, Gavin OL	anon	pdb_2r9g	Domain	The MgsA protein possesses DNA-dependent ATPase and ssDNA annealing activities [1]. MgsA contributes to the recovery of stalled replication forks and therefore prevents genomic instability caused by aberrant DNA replication [1]. Additionally, MgsA may play a role in chromosomal segregation [1]. This is consistent with a report that MgsA co-localises with the replisome and affects chromosome segregation [1].  This domain represents the C terminal region of MgsA.	21.00	21.00	21.00	23.60	20.70	20.20	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.93	0.71	-4.57	278	4662	2009-07-07 16:02:56	2009-07-07 17:02:56	3	19	4329	28	1089	3504	745	165.20	43	37.81	CHANGED	GSDPDAALYaLARMl-uGEDPhaIARRLlhhAuEDI.GhADPpALtlAhuAhpAhctlGhPEuclsL..AQAllYLAsAPKSNusYtAhspAhpsl+p...ssshsV.PhHLRNAssphh+clG....aGpsYcYsHDhs....sua.ssQpY..LP...-p.lps......t.......aYpPs.ppG..hEpclpccLpplcp	.............................................GSDsDAALYa.hARhlcA.GtDPhalARRLlhhAuED...IGhA-PpAhtlAluAh.puh..pc.lG.....hP.E.u..c..l.sL..Ap.All.aLAhuPKSNusYpAhstAhssl.+p....s...s....s...h....sV.PhH..LRsA..hph.h...K....c.LG...................h.G.ps..YcYsHDhs.........sua...ss...........QpY..hP-clts.......pp....aYpPs..spG...hEtpltpphthlt.p.......................................	0	359	698	920
+11836	PF12003	DUF3497		Domain of unknown function (DUF3497)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3419 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 213 to 257 amino acids in length. This domain is found associated with Pfam:PF02793, Pfam:PF00002, Pfam:PF01825. This domain has a single completely conserved residue W that may be functionally important.	27.20	27.20	27.60	27.20	27.00	27.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.51	0.70	-11.31	0.70	-4.98	32	930	2009-07-07 16:18:38	2009-07-07 17:18:38	3	137	93	3	416	750	0	222.40	24	14.93	CHANGED	tp+hpsscss..p.lspcLtchT.....ps.shauuDlhssscllpplsphhs.pttthhsspccst................................................................pshVpsssNLLc.pstppWcplppscp....suopLLcslEchshhlApsh...hth..pphhhsssNlhLplthhssps.hps..hFPp..........hphstsplplstpshptssp........................................sG....shlshllY+sLGtlLsspssshth...tp.....hpsssp....hlsosllssslspp	..........................................................phhsGcsss..plsppLtchT......ps..sh..auuDlhsolclhppls..s.hhs...p....htth....h....su....s.p-sthp..............................................................pshVpslssLLpscshptWc....chppsct........sushLLcslE-huhsLApsh............hth.........p.ht.....hso...sN...l........h....L.pl.t.h..lssps..hps..hpFPp.................................stsstspl..plst.sshp.ssp...................................................................su......hhlshllY+..sLGthL.ss..p..p..ss..hth........t...............t.stp..................hlso.llsssl.....................................................................................................................................................	0	73	107	227
+11837	PF12004	DUF3498		Domain of unknown function (DUF3498)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3438 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 433 to 538 amino acids in length. This domain is found associated with Pfam:PF00616, Pfam:PF00168. This domain has two conserved sequence motifs: DLQ and PLSFQNP.	29.50	29.50	31.40	31.40	28.80	29.20	hmmbuild  -o /dev/null HMM SEED	495	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.91	0.70	-5.36	7	291	2009-07-07 16:20:56	2009-07-07 17:20:56	3	9	66	2	120	241	0	410.40	38	42.45	CHANGED	LpDlotALsNPsslppps.......spc....+sss........P.susulSoGlQp.hh.pDls..............u.sDhsRLPSPT...........................tsKDlFaVo+sshhpsSPuhsS.S.S-hsEs-h..thssG............+SlShhDLQ-...............spstp........uhs......s...........hstpsspushsss..lpp..........ssph....css.sp..thLhPLSFQNPVYHhusshP...ssst.....cuuopscuosSSH.........................SssE-h.h..........h..pt......c-hst+ss...-hoccphshst...ttp.....slPppsosG.t..R+h.............sututpuph......Pssh.....t.h..........pssshhss..................p.spsG.u+.+QpopSppt-sss.+stuh..tts...........SPss......ssl-RTAAWl.N.N....-...........c...spc-hppsEK.....YppEIshLpE+LRhSsp+L-EYEtRLhsQ-pQhQKhL.EYQtRL--SEpRLRp.Q.-KD.QhpuIIsRLMuVEEEL++DHu-MQtVl.-uKQKIIDAQc+R...hsuLpusss............................RlhsuLs.lpE+a	................................................................................................................................................................LtDlphuLpsPt..p..............t-..h..s............s.h.tu.SuthQt.hh..pshs.........................Dht+L.SPo...........................tspD.aahs+s....hh........psu.po.o.S-hsE.-...ph...ss............+SlShhDLQs.............................stshph..ts..s.......s..s.................................h..t..ss......thsth.....plpp..........ss.h.......css.....sp..thh.PLSFQNP.laphsssh.P...h.Ptu............cuu......t...sh..us.SS+.......................................S.pSE-hth..........................h..ps..................--hspp.s.s.......-hsR.R..phs..p.....ph............h.Pt...Q..so.sG.t.....Rpht............................ss.....s.s...pups............Pssh.........tph............................SoGs.h..u.......................................................t.s......t.G..sR..R.QQ.SpSpc.........p.ss....p......p.....s.h.tt.tts........................................oPss................ss..-RT...s..AWl.s...st...-................ch.p.pcph.p..psc..........................................hpp..-IthLp...-+L+hSs++LEEYEpchhsQEp.phpKllhpYp..AR...LE-...uE.....cRLRpQQt-KD.QhKuIIuRLMsVEEEL++DHs.......c.Mptsl.-sKQ+lIDA......QE+p...IsuLcuANs............................RLhsAlttlpt.....................................	0	16	27	63
+11838	PF12005	DUF3499		Protein of unknown function (DUF3499)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3439 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 125 to 163 amino acids in length.	25.00	25.00	27.20	30.20	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.86	0.71	-3.95	18	376	2009-07-07 16:22:24	2009-07-07 17:22:24	3	1	375	0	101	250	99	115.10	47	91.41	CHANGED	ss.RRCSRsuCucsAVATLTYVYADSTAVlGPLAshuEPHoYDLCspHAcRLTAPhGWElVRlsst.t.....sstPssDDLhALA-AVREAup..stt.s.s.........................ssshssP........pssR....RGHLRVl..........s-s	....R.C.+suC.t.AsATLTasYu-STAVlGPLAs.t.EPHuaDLCspHAp+lTAPpGWEllRhsu......................sscPssDDLhALAsAVREuGhstst.hhsts.....................................................................ss.....tstthsR........RGHLpVlsD.s.....................................................................................................................	1	33	78	97
+11839	PF12006	DUF3500		Protein of unknown function (DUF3500)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3479 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 335 to 438 amino acids in length. This protein has a conserved GHH sequence motif. This protein has two completely conserved G residues that may be functionally important.	27.20	27.20	44.20	29.00	27.00	23.30	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.11	0.70	-5.49	36	209	2009-07-07 16:26:39	2009-07-07 17:26:39	3	7	142	0	112	226	111	297.20	27	81.26	CHANGED	stpspsssssshhsAApshLssLsscQ+ppshhs..........h..Dssptps.........W.s.h....sh......RsGlslsphsscQ+phshslLpssLS...spGapcstslhth-.p.......hL...........phtttt.........................hs.tpYalslFGs...Pus...s..psWGapatGHHlulNhsh..ssspl.shoPhFhGupPsthpp........hsG..hp.....sLtpEcshuhpLhpuL....sscQpppAhltpth...............................................sc.hphsushtc.....................h..pGltsupLsssQpchLhsllpp.Ylshhspphsc..tphscl..ptthspsaFuWhGs....htsscsaY..aRlpuPshllEassps..................sstsHlHolhRssss.DaGts	......................................................................h....t..htthhtAupshlssLsspQ+ttsth.......h......ss.phpp..............................................W.s..........h.............+tGlpl.sp..hss..t..pppsshplLpssLS....spGYpcshshhths.p.....hLt..........ph.st.......................................................................hsttsY.hslFGp.....Pus....................s...psWuhphtGHHlslNhhh...sspl.shoPhFhGspPshhst..................htG...hc.....hhttEpphuhpLhpuL....ssppptpAhl.tth...............................................p-.hphsus.tc.....................hs.pGlhsu..phospQpphlhsllpp.althhspphtp..tphppl..ptthscTaFuWhGs....htssc..s.hY..aRlpuPslllEaspps..................sst.HlHolhRs.ss.DaG..t.................	0	49	81	103
+11840	PF12007	DUF3501		Protein of unknown function (DUF3501)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3488 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and archaea. Proteins in this family are about 200 amino acids in length. The structure of protein Swiss:Q63J81 from B. pseudomallei has been solved. This protein contains two domains, domain I (1:31, 46:81) is a helical domain, domain II (32:45,82-193) is a mainly beta protein with a beta barrel. According to crystal contacts the proteins probably functions as a dimer. The gene neighbourhood analysis suggests that this protein may be functionally related to rubrerythrin and ferredoxin. The wedge surface between the two domains might be functionally important. The fold of this protein could best be described as a circularly permuted C2-like fold (details derived from TOPSAN).	25.00	25.00	104.10	103.70	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.09	0.71	-4.63	22	127	2009-09-11 15:56:04	2009-07-07 17:34:23	3	2	125	2	46	112	664	190.20	41	94.10	CHANGED	hplshsslhs.hpsYu+hRtph+spllthK+pRpVplGstlslhFEsptTlRaQIQEMl+lE+hhc-tsIpcEl-sYssLlPsuusLpATlhIEhsc.s-RcptLscL.hGlccplalclsstt.tlhuls-tDhtRpss-.+sSoVHaL+F-lsss.hsth+s...uss......ltlGsDHssYshpst..lsssstpuLhsDLt	........................plTRssLLo.lEsYuKlRtph+s+llshK+cRtVplGs+lpllFEscsTlpYQIQEML+lE+lh-cpsIppEL-AYsPLlPcGssLKATlhIEhps.scR+ttLs+L.hGIE-claLcVssct..VhAIA.....-EDh-R-su-.KTSuVHFLRF-Lssshhsth+s...Gss...lplGsDHPsYshpst..lsssltsoLsuDL.....	0	14	30	40
+11841	PF12008	EcoR124_C		Type I restriction and modification enzyme - subunit R C terminal	Mistry J, Gavin OL	anon	pdb_3evy	Domain	This enzyme has been characterised and shown to belong to a new family of the type I class of restriction and modification enzymes. This family is involved in bacterial defence by making double strand breaks in specific double stranded DNA sequences, e.g. that of invading bacteriophages. EcoR124 is made up of three subunits, HsdR, HsdS and HsdM. The R subunit has ATPase and restriction endonuclease activity. This domain is the C terminal of the R subunit [1].	21.60	21.60	21.70	21.70	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.93	0.70	-5.20	79	1157	2009-07-08 08:20:11	2009-07-08 09:20:11	3	9	1042	10	158	990	58	263.60	21	28.79	CHANGED	hlLhcsapchhcpapc............slp-Lpphhsss.......thspl..ts-psccpFlchFpch.+htstLpsas-.as.........................sptpht................hsppphp-acutYhsltpcl+cpp...ppppt.........s....pDlcF..El-LlcsscI...........NhDYIhpLltch..........ppspppppt..hcplhchlps..s.thcsccclltpFlpplph...........ph.sppslpctappatppcppcplpplspppsL....stctlpphlsshh...tptph..ptsplsc......hls.hphth......tpphp.....hcpplhpcltshlc+a	..............................lLhcsac-hhptapc...........................shpcLpphhsss....................hspl...tsEppp+cFlchFtph.+hhphLpsa--.ap...............................s.ttht........................hsppph..p-Yc..utY.slhcpl+...cppt..pppp.................sh...sDl..sF..El-h.h+stp.I...........NhsYIhpLltph.....................pppt..pppp.hc.....plcc.....hlpp........s.p.+tcccllppFl.p.php..................ph.psp...s.ltpta.pah.ppcpppchpthhpcpsl.....sppth+phhsphh...tt..hp.p.tt.tsplsc..........h...phhh.............phhp........h+ptlhptltthhcc......................................................................................................................	0	53	104	135
+11842	PF12009	Telomerase_RBD		Telomerase ribonucleoprotein complex - RNA binding domain	Mistry J, Gavin OL	anon	pdb_2r4g	Domain	Telomeres in most organisms are comprised of tandem simple sequence repeats [1]. The total length of telomeric repeat sequence at each chromosome end is determined in a balance of sequence loss and sequence addition [1]. One major influence on telomere length is the enzyme telomerase [1]. It is a reverse transcriptase that adds these simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme [1]. The RNA binding domain of telomerase - TRBD - is made up of twelve alpha helices and two short beta sheets [2]. How telomerase and associated regulatory factors physically interact and function with each other to maintain appropriate telomere length is poorly understood. It is known however that TRBD is involved in formation of the holoenzyme (which performs the telomere extension) in addition to recognition and binding of RNA [2].	21.20	21.20	22.20	22.60	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.70	0.71	-4.25	54	413	2009-07-08 09:22:28	2009-07-08 10:22:28	3	9	237	6	156	402	1	125.40	26	14.05	CHANGED	ppVstFlhshlpp....ll........P.ph.aG.........spcNppthh.pplppalph.t+aEphslpclhptl+lschp.WLtttttsppht.......................chpppppllt.......palhWlhp.pllhsll+shFYlTE....p..ttppsclhYaR+slWpplsp.slsp..htp	...................................pVhtFlhthlpp....ll..............P.ph.hG..........................sp.pN.pphhh.pplppalpl.t+atphslppl.hpth+l..p.........sht.WLp.t.th..tt.p.h.............................................................................phphpppllt.........palhW.lhssh.ll.LlpshFYlTE....s..thp+p..plhaaR+slWpcL.p.tltph..t..........................	2	52	83	123
+11843	PF12010	DUF3502		Domain of unknown function (DUF3502)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3448 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 140 amino acids in length. This domain is found associated with Pfam:PF01547.	47.30	47.30	47.90	47.30	47.00	46.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.51	0.71	-4.19	18	679	2009-09-11 16:21:44	2009-07-08 11:40:33	3	5	494	0	91	398	5	134.70	42	27.71	CHANGED	GIEGpHY-+lscs................pI+hhss..psY.shss.Wsh..GNhhl...phshEs-s..D+W-pacchsppApsSPhLGFpFDsssVcopIuulsNVhpcapssLhTGoVD.P-ctlschhpKLcsAG.lDKVhcEhQ+QLD-a.ptpsp	.....................G.EGcpaEKlssp................+l+....lL.....c....u...h...p..s..s.......h.....c.h.u.u....Wst.....GNshI....l.Yhp...Es...s...s-....p...plcp.p.c....c......h.tc....A.+..p.S.P..hLG.FhFsocsVKoEIoulsNlhppatsulsTGTV...D..P-cs...lPcLhcKLKsuG..h-KVhpEhQKQhDEa.lpsp........	0	56	77	82
+11844	PF12011	DUF3503		Domain of unknown function (DUF3503)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2686 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in viruses. This domain is about 170 amino acids in length. This domain is found associated with Pfam:PF00271.	25.00	25.00	54.30	52.00	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-11.18	0.71	-4.53	12	81	2009-07-08 10:43:55	2009-07-08 11:43:55	3	4	41	0	0	79	0	166.00	60	25.25	CHANGED	M-NcLPsIFaFPNCVslFPacYSQpEh-cMppp-+ctFShAVFPlIKHRWpcuallhc.spsaKLssE.pp.ph..p+ls.ssl.s.....Psplshph+pYhhss.h+IoFECYSYLpCpphs.clpshs-...llRGLlEGGNpLpIFSssh.....G.phssoIGIhGNspPFsKlPLtSLpP	.......MEKNLPDIFFFPNCVNVFSYKYSQDEFSNMSc....sER-uFSLAVFPVIKHRWHNAHVVKH.KGIYKVSsE..A.RG..+KVSPPSLGK......Ps+INLouKQY.IYSE.+sISFECYSFLKCITNs..EINSFDEY..ILRGLLEAGNuLQIFSNSV.....G.KRsDTIGVLGNKYPFSKIPLASLTP................	0	0	0	0
+11845	PF12012	DUF3504		Domain of unknown function (DUF3504)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2196 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.	29.70	29.70	29.70	30.20	29.60	29.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.91	0.71	-4.49	23	439	2012-10-02 14:09:14	2009-07-08 11:46:23	3	21	79	0	263	356	1	158.10	35	17.41	CHANGED	uhlh.Scl-E-hLWps+p.LGspSPhsLLpoLhaasT...KYFsl.+Tl-pHtcLuFuplh+ps+pt.........tsc.shlRahssp.t.pstpsh...ucppc...................ptt.h.hp.h-ssssPh+CPVpha-hYL.Kps..slcptpssFYLpPc+sssssuslWYsppslucpsLpphls+lhhs	.......................................................................lh.S+l-E-hLWcs.KQ.LGsaSPhsLLsTLhaFNT...KaFsL.+Ts-pHhcLuFuplh+pp+p....................tsc.shlRah...s.s.h....ttp.s..t..p..t........scpp+...................ppt.h...hE.hENsp.NPh..RCPV+.....la-hY.LuK.sP..psl+pRs..DsFYLpP......E...p.....s.s...........ss........s.S.....P........l....WYospslscspLppMLsRlhh..........................	0	90	109	169
+11846	PF12013	DUF3505		Protein of unknown function (DUF3505)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2856 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 247 to 1018 amino acids in length. This region contains two segments that are likely to be C2H2 zinc binding domains.	26.60	26.60	26.60	26.60	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-10.86	0.72	-3.82	16	197	2009-09-11 05:54:46	2009-07-08 11:50:44	3	15	33	0	172	211	0	103.00	23	12.06	CHANGED	pLFha.spapVhICRp..CcauVhP..pplpsHL+t+H+ph........psttt.....plppsl.........psas..tpcspssphPs.s.s.PlPtLPla.sGhtC..s.spCpYlspshpsh+cHhpppHs	.........................................h..ph.llICpp..Cpaulhs.....splpsHLpp.cH+th.............tt.tp..tltptl..............ppht......l..htss....p...s...l....p...h..Ps....t.stPlstL..shh....sG.ht.C.................stC.ta.hstshpshppHhpppH...................	0	42	80	167
+11847	PF12014	DUF3506		Domain of unknown function (DUF3506)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3293 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 131 to 148 amino acids in length. This domain has a conserved KLTGD sequence motif.	39.70	39.70	41.00	39.80	38.80	39.00	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.79	0.71	-4.35	12	152	2009-07-08 10:53:22	2009-07-08 11:53:22	3	10	108	0	101	146	1	130.20	41	25.46	CHANGED	pslosaspl-...hoPoppcPapGlalGsausaGsEhlhLpp+.Gp.ptscssppp.................psh.hhthlEAlKLTGDPNVPtGploFhAc.IGcpshlp..cc.sha....Gs..thh+upG+lAs.GF+sscal-u-Llhlssc	...................................p.t.otaspl....hsssspcPapGlaVGsausaGsEhl.lp......p+.sph.......tps.................................................................ssh.ahthlEAlKLTGDssVPtGploFhAc....lGp....s.uhlp..pc.shas.........Gs...thhKupG+lApsGF..+ss+al-ucLlllssc...................	0	23	58	84
+11848	PF12015	DUF3507		Domain of unknown function (DUF3507)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3482 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 180 amino acids in length. This domain has a conserved ENL sequence motif.	25.00	25.00	25.30	25.80	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.04	0.71	-4.78	10	67	2009-07-08 10:56:31	2009-07-08 11:56:31	3	2	65	0	45	66	0	169.00	29	11.77	CHANGED	lsslph.htols.sphhstps.hp.tpp.ppcWspl...FspuslFpGhD-llaGphlshVYccscos+lssh.lsKaGlosacNlslsspSRFaPAsENLpPcYpcSsVRRsLAlohLKp.......YsLLsssshphl.sphs...saDpTaAG-LAsshpLlss.psPp-hGppLlphGLLQs..+slpShllDVV	.............................h......................................tphshapu.Dsll......aG.hl.....sss.pssp.o.....s+lpuhllsphGhpsasplslSssStaYsAlpNLs.ccQpspVp+uLAVshLKh.........aspL.ssst...hppl.....t....s.........phs.....ptaDEhaAG-LAspM.phlps.t.........s.........chspplh..GhhQp..+h.l.sh.lDVl.......................	0	7	20	39
+11849	PF12016	Stonin2_N		Stonin 2	Mistry J, Gavin OL	anon	pdb_2jxc	Family	Stonin 2 is involved in clathrin mediated endocytosis [1]. It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs) [1]. In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling [1].	96.90	96.90	125.00	124.30	96.60	96.30	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.26	0.70	-5.29	2	50	2009-07-08 10:57:23	2009-07-08 11:57:23	3	3	30	1	27	46	0	287.10	77	35.28	CHANGED	MTTLDHVIATHQSEWVSFsEEP.FPs..pGGTEEHhPGLSSSs-pSESSSGENHVVDtGSQDhSHSEQDDSSEKMGLISEAASPPGSP.QPsPDLASAISNWVQFEDDTPWuSTSPPHp...ETALsLTMPCWTCPSFDSLtRCPLTSESSWTTHSEDTSSPShusSYTDLQLINsEEQsSGpASGsDSTDNSSSLQEDEEVEMEAISW.AuSPAMNGHP.APPVToARFPSWVTF-DNEVuCP.PPVsSPhKPNTPsuAoshPDVPaNShGSF.KRDRPKSTLMNhsKVQKLDISSLNRsPSVhEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQER	................MTTLDHVIATHQSEWVSFsEEP.FPs.SpGGTEEHLPuLSSSsDpSESSSGENHsVDGGSQDhSHSEQDDSSEKhGLISEAAS.PPGSP.QPsPDLASAISsWVQFEDDTPWuSTSPP.Hp.s.E.TALsLThPCWTCPSFsSLtRCPLTSESSWTTHSEDTSSPShusSYTDLQLIsAEEQsSGpASGADS.TDNSSSLQEDEEVEMEAISWQASSPAMNGHP.AsPVTSARFPSWVTFDDNEVSCPLP.PlTSPLKPNTPPsASVhPDVPYNShGSFKKR-RPKSTLMNFSKVQKLDISSLN+s.PSloEAPPWRATNPFLNETLQDVQPSPINPFSAFFEEQER....	0	1	2	6
+11850	PF12017	Tnp_P_element	Transposase_37;	Transposase protein	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3357 (release 23.0)	Family	Protein in this family are transposases found in insects. This region is about 230 amino acids in length and is found associated with Pfam:PF05485.	34.00	34.00	34.30	34.10	33.30	33.90	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.61	0.70	-5.13	6	118	2009-07-08 11:00:53	2009-07-08 12:00:53	3	6	45	0	59	139	0	205.90	34	36.85	CHANGED	uNuSTQTEssllsp....ENcoLRpKIRsLEpEl+pLRQQLE-uppLEpSLspIFT-TQIKILKsGGKRusFNSsDhSsAICLHTAGPRAYNHLY+KGFPLPSRsTLYRWLSDV-IpTGsLDVVIDLM-N--MD-ADKLCVLAFDEMKVAAAFEYDSSADllYEPSsYVQLAhVRGLKKSWKQPVFFDFsTtMDsDTLpsIIpKLH++GYsVVAIVSDLGsGNQ+LWpELGISEp.K	..............................................................t....p.hcp....plp.p......hchchp....pLc...p....pl.....c.p...........p....p...lc.....c....sL...pph......Fop.s..Q.l.+..h...L.......p..ss.s...p.+..s.p.ass--hutAlsL.+...s.s.uP+uYpaLh.c.+.saPLP....SppTLh+a.lsslplp.G.hh..c.s.llcl....h....c..s..c...t..h...s...ptD+..lC....lLsaDEMp......lssth-YD...............s..........s.......t..........D.....h........l............h...........c.........s....u...sa.....lt.....ls...hlRGlpcsWKQPl...aa.....sF...s.o...t.Ms....s..ssL....p....p....I....l....p....+....LpphGh.VlAlVSDhGssN.phhpcLGl...................................................	0	23	28	57
+11851	PF12018	DUF3508		Domain of unknown function (DUF3508)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_3527 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 280 amino acids in length.  This domain has two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704.	25.70	25.70	26.20	26.10	25.40	25.60	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.70	0.70	-5.42	10	142	2009-07-08 11:03:06	2009-07-08 12:03:06	3	5	95	0	95	138	2	241.40	28	45.54	CHANGED	ulLccslPsosp+I-ppLpsspctshcYTulLEchst....ssthspcl...h..LK-ALYNlRQaEsFLphlLoDlhssApp......V.EhhppchtuplEpLKpsl+sKoAVPTsQVF.....PhFsALupLWsuLp-EphLlssLsNLhspLpsFlssacLhhP..tpsh.slLsstsV+oDtsRhcp.........shtcclslu-apspEa...LhPEsTAsFpcL.lQYpGFCuaTlss+DGLLLPGNPulGlLKa+-KaYsFuo+cAAh.cFupc.P-pYIstltEpA++ssELIpLLcLcQpFpol	............................................................s..lp.s...h.ptlptplp...tstp.shpa.sullcphht...............sshhttph...h.....hp-tLhphRQaphalphlhpsl.thtpp.......l.p.hhpphtsthpplp............s..........l..........p...........+s..........ulsotpVa..............PhFhtLuplWs.shpc.Eh.hls.lsplhtplpsh..ht.s..pt.hhs....t.h.h.thL.p.....th.lps.c..p.chpc..................................p..h.....hphs-h...pp....ph.........hhs..ps...sssh...p..c...h..l.papGFCuhohstp....s.G...LL......l...........PGs............P...sl..Gllpa....pp....+hYsFsoc-ush.pFupp.P-palthlhchs+ppscLlpLlpLppph...h...................................	0	37	49	74
+11852	PF12019	GspH		Type II transport protein GspH	Mistry J, Gavin OL	anon	pdb_2qv8	Domain	GspH is involved in bacterial type II export systems [1]. Like all pilins, GspH has an N terminus alpha helix [1]. This helix is followed by nine beta strands forming two beta sheets, one of five antiparallel strands and one of four antiparallel strands [1]. GspH is a minor pseudopilin; it is expressed much less than other pseudopilins in the type II secretion pilus (major pilins) [1].  The function and localisation of minor pseudo-pilins are still to be fully unraveled [1]. It has been suggested that some minor pseudopilins may assemble either into the base or the tip of pili, or both. They function as initiators or regulators of pilus biogenesis and dynamics, and/or as adaptors between various pseudopilin component and other members of the T2SS [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.61	0.71	-3.93	214	1652	2009-07-08 11:47:00	2009-07-08 12:47:00	3	3	953	3	399	1257	143	122.00	15	68.53	CHANGED	ssppLtsslphARscAlp..p.spslslsstss..stth................tt...Wssuhhlhht..tssstt....t...........................thssshphshs...........................................ssplpF..s.ssGhs..........................tshs..ht.......hsssspspt..............l.hl.ss.....sG	.................ApclhstlphA+scAlh..p.s...ps.lslphs...ss..uhph..........................tsp...W..pss.htshhs....ssstt..........tth.h........................h.ssssththp.t.....................................................sspltF..p..spG.s................................sshs....lp.........htssstt.....................th...........................................................................................	0	100	222	319
+11853	PF12020	TAFA		TAFA family	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3899 (release 23.0)	Family	This family of secreted proteins are brain specific and thought to be chemokines [1].  These proteins are found in vertebrates. Proteins in this family are typically between 94 to 133 amino acids in length and contain a number of conserved cysteines.	25.00	25.00	25.90	41.70	16.90	16.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.24	0.72	-3.88	3	241	2009-07-08 13:15:59	2009-07-08 14:15:59	3	2	38	0	140	188	0	84.20	68	71.79	CHANGED	+sGTCEVIAAHRCCNKNRIEERSQTVKCSCLPGQVAGTTRA+PSCVDASIVlQKWWCcMEPCLEGEECKVLPDpSGWSCSSGNKVKTTRV	..............sGTCEVlAhHRCCNKNRIEERSQTVKCSChPGQVAGTTRApPSCVD..............A.SIVhpKWWCcMpPCL-GE-CKlLPDhoGWoCoo.G.N.KlKTT+l.....................	0	5	20	68
+11854	PF12021	DUF3509		Protein of unknown function (DUF3509)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2180 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 92 to 110 amino acids in length. This protein has two completely conserved residues (G and R) that may be functionally important.	25.00	25.00	25.20	25.00	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.93	0.72	-4.24	19	201	2009-07-08 13:16:45	2009-07-08 14:16:45	3	1	60	0	39	130	2	93.10	31	94.84	CHANGED	cph.phls-sFss.YpVshu..csDGullLTLpsssG.hlh+RhlotsQhs-tppLppllsul+R-LAlctGchs.plluthppt..............schts..........httt	.....p..phls-sFss.YpVshp.sRsDGulLLTLpsppG..hlhcRslossQLs-.ppLppllpulRR-LAlptGch..plluthppt...........tp.........h....................	0	2	6	26
+11855	PF12022	DUF3510		Domain of unknown function (DUF3510)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2857 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 130 amino acids in length. This domain is found associated with Pfam:PF06148.	29.10	29.10	29.70	30.10	23.90	28.80	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.45	0.71	-4.02	21	198	2009-07-08 13:21:08	2009-07-08 14:21:08	3	8	161	0	133	191	2	126.70	34	17.21	CHANGED	lpplhppsh.ptLcplpslsphYRhTN+psPop......sSsYVssllpPLpsatptt......thlspthhcchlpcllsplocpYhptss-llsoVcKpp-SLpRl+ptptpsuss...............shsD-DKI+hQLhlDl	..............................ppLscpCh.p.L+p.spslPphYR.tTNKp..lPop.............sSsYVssh..LcPLpp.hhstp............................pshltpthh....pphlptslspsTccYhphls-VLsoV+KhEESL..........+..RLKpspppssussss................................sssuhSD-..DKIRlQLhLDV.............................	0	56	76	109
+11856	PF12023	DUF3511		Domain of unknown function (DUF3511)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3314 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain has two completely conserved residues (Y and K) that may be functionally important.	25.00	25.00	33.70	32.60	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.32	0.72	-4.64	14	157	2009-07-08 13:24:58	2009-07-08 14:24:58	3	4	20	0	99	137	0	46.60	52	35.52	CHANGED	hthsDPEhKR+RRVAuYKsYuVEGKlKuSlR+ua+WIKs+ho....p........llcG	.......hsDPEh+R++RVAuYKsYuVEGKlKuSlR+uF+WIKs+ho....plhaG.................	0	12	58	82
+11857	PF12024	DUF3512		Domain of unknown function (DUF3512)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3525 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 231 to 249 amino acids in length. This domain is found associated with Pfam:PF00439.	33.70	33.70	37.20	34.40	28.00	30.30	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.52	0.70	-5.08	13	193	2009-09-11 13:40:57	2009-07-08 14:46:16	3	5	85	0	107	170	0	213.90	36	37.66	CHANGED	ppKc.s....+p.h+ht........cscspspshssshstE+lLtplcpsucEAps+ls++hssuKhGFLR+psDGoTohslltss-sputEt..sp+sVsLGshsGKLpsGsssLtGFKED+RNKVTsVs.LsYGsaoSaAPpaDSsFuslup--oDLlYuTYG--oGspsAhSlp-FlcssspaupthscsLLDhlTsG-HS+oltplppppppp.p.sc......................pspstttppusshlDatuL+oloslGlDsphL	.........................................................p.p....+p...phh........ps.hptp.hsssh...E+..t.lcphscE.uts+ls.phhssuphta.++psDGohh.hsllp..ss-s.st-..........thpsVcLu.hou+L.s..Gh..s.oL...G.FK..-D+RN+VT...lp.h..YusaoSaAPpaDSsFuslsp--o-LlYSsYG-.......-oulps.uhS..lpEFltss..ssYsht.hsDsLLD.lTsG-HS+ol.plcppp..s.t...c.................................pht.s.h....tss...s..chhuhcshs.shulshphh.......................................................	0	26	34	66
+11858	PF12025	Phage_C		Phage protein C	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3530 (release 23.0)	Family	This family of phage proteins is functionally uncharacterised. Proteins in this family are typically between 68 to 86 amino acids in length.	25.00	25.00	61.90	61.70	24.50	21.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.26	0.72	-4.02	3	67	2009-07-08 13:51:34	2009-07-08 14:51:34	3	1	54	0	0	34	0	65.40	71	83.07	CHANGED	sLSL+sSRSSYFATFRHQLslLoKTD.ALDEEKWLNMLGsLLKDWFRYE-HFVHG+cSLlDILKERGLL	sLSL+sSRSSYFATFRHQLslLoKTD.ALDEEKWLNMLGshlKDWFRYEsHFVHG+cSLlDILKERGLL	0	0	0	0
+11859	PF12026	DUF3513		Domain of unknown function (DUF3513)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3541 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 192 to 218 amino acids in length. This domain is found associated with Pfam:PF00018, Pfam:PF08824. This domain has a conserved QPP sequence motif.	25.00	25.00	28.20	28.20	21.60	20.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.38	0.70	-4.78	14	329	2009-09-16 12:09:40	2009-07-08 15:01:52	3	10	100	3	138	289	0	197.70	44	27.92	CHANGED	ssst.p.phsttthhEDYDYVHLpup-php+pptplhc+t..............................................t.pp.EpLcppstcstpps...............oPsp.hs.........lsspD+pLLhaYucQCptahssLhpAlsAFhuSlsssQPP+lFlsHuKhVIluAHKLVhlGDTLsRpspst-lRscVhpsSstLCphLKslVLuTKsAALpYPSsuAlp-MsscVpcLsppsppF+shLt	....................................................................................s......p.sttshh-DYDYV+LpG..+-c..hp+ppcplh-pt.sh.....t.......................................phppachLcp.phs.p.s.h-ps..h.tt...........................................pPspshs..............sssluspD+QLLhF....Yh..-QCcsahssLhsAlDAFao.........sVussQPP+...........IFVAHSKFVILSAHKLVFIGDTLsRpsput...DlRscVhptSshLC-hL+slVhsTKtAALpYPSssAhQ-MVcpVp-LuppsppF+psL.h...........	0	22	34	72
+11860	PF12027	DUF3514		Protein of unknown function (DUF3514)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3570 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 368 to 823 amino acids in length.	25.00	25.00	27.30	33.70	16.20	20.30	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.71	0.70	-5.14	26	49	2009-07-08 14:03:17	2009-07-08 15:03:17	3	2	7	0	32	48	0	222.90	18	45.07	CHANGED	lhh+s-l.shLpph.ssphchsshllKluhlhp.hhhhhst.ph...sptlhhs.t.phhc.phlD.lLhclhssspss......thshpthhphhhshptpph.spshthasssF..appllslhpcll.ts+hsssh......h...pllshlllSCslplGsMY......t.hthhsptsss.tp......................ptthhshhshplhpshtahYssssp...slphl..sslshPphllchCSpph.hsplpppltpsph..sFslhhpclspplsphlspps	......................hhp.ph.phl.p..hpp.phthhllKhshl.p.hh.hhsh.th...sp.lhhs.t...h-..hl-.lLhplhsh.pps.......h.hphhhthhhshhtpth..tshthhsssF......Ypplhplhtplh..h+.sps.......h....plhshlllussh.lGtha........hhhhtp.tht.tt..........................t.h.hshhshplhhshhahYssssp.....l.hl..sshshPthllphsSpth.hs.lpp.htpsph..sFslhhpslspplsphh.p........	0	9	9	9
+11861	PF12028	DUF3515		Protein of unknown function (DUF3515)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3590 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 166 to 214 amino acids in length. This protein has a conserved RCG sequence motif.	25.00	25.00	37.50	32.40	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.28	0.71	-5.00	26	415	2009-07-08 14:05:35	2009-07-08 15:05:35	3	2	352	0	114	292	45	149.20	30	92.10	CHANGED	tssllussslsslLssAusht.....tslulushPAPpAssst.CpsLhssLPppLushpRuthh-PsstGsAAW...Gss.tsllLRCGl-p.Psp.hsssush.sV..cs...VpWhtsssts...sus.........................so.has.VsRsshVtlTls.sss.......Gs.oshpsLoslhsss......hthtshpsss	..........................................................h.........hhhhhhhsh..........................................s..sh.s.sss....ust............Assst...Ctslh..ssLPpp.l.....u.....s....ht+....t...s..hh...ps...s...ss.usA.......uW.....Gss...sl.l.LRCGV-p.Pu.....t....h.........p.........s..s.......ush.ps.........V.........ss...........VsWFp.psss.....G..............................................ts.hao.lsRtshVtlTlP..ss.t.......us..tshss.Ls-lhsshhths..t..........................	0	34	87	110
+11862	PF12029	DUF3516		Domain of unknown function (DUF3516)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3601 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with Pfam:PF00270, Pfam:PF00271.	25.00	25.00	31.60	30.80	21.60	20.50	hmmbuild  -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.60	0.70	-5.68	23	417	2009-07-08 14:07:34	2009-07-08 15:07:34	3	5	397	0	120	382	22	445.70	48	54.35	CHANGED	APEH.lENt+thAKA....GDDP...KKpRKlhRKKsPE.GaVsWucsTF-RLlpAcPEsLsSpFcVopuMLLNVl..........uRsGDsasuh++LLp-NH-sRspQp+hl+RAltlaRuLlsAGVVEc.l..-pPD....spGR.psRLTlDLQtDFALNQPLSPFALAAL.ELLDsESsoYALDVlSVlESTL-DPRQVLhAQQcpARGEAlAtMKA-GlEY-ERMtlLEEVTaPKPLtElLcsAa-hYRpuHPWlsDapLuPKSVVRDMaERAMTFs-aVspYGLuRSEGlVLRYLuDAY+AL+pTVP--tRTEELpDlI-WLGELVRQVDSSLLDEWEpLssPss...stssp........shsspsPpslTANpRAF+VhVRNAhFRRVELsAtcch.stLupLDs......tsG....hssssWp-AL-sYa-EH-cIGTGPDARGPpLhhl-cs..........s......................c......hWpVRQllcDPsGDHDWuIsApVDLsASDEAGcsVlcssslsp	..................................APEH.IENtKAlAKA........GDDP.....KKh+K...l....tRKKsPE.GFVsWuEpTFp+LlpupPEsLpu+h+lTcuMLLNll............sRs....G.....D...shtshc+Llcsspp......shtppp+hhcRAlpIacoLlsusVVc+l......-pP.s...........ssG.R.....phtlsh-LpcDFALNQPLSsFALAAl.-LL......D.....P......-S......s.................o......Y..ALDVlSVlEATL-cP+plLhAQp+pARGEAlAtMKA-Gl-Y-ERMttL--loaP+PLc-hLpsAF-hYtpupPWls-htLpPKSVVRDMhE+AMTFs-alupYtlsRSEGlVLRYLoDAYRuLcpTVP-st+o.-ELpDlIpWLGElVRplDSSLlDEWEpLssPts........ttspp.........................spsspslTuNpRAFpVhVRNAMFR+Vp.LhAh-ch.-tLGt...L-s.......................thu...........hsss.sWp-sLssYaDEa..--lssGs-ARuPtLhhl.-pp................s.....................................c...hWpVRQI..lcDPsG-HDWuIsApVDLsu.o.D-sGcsVlcshsh.s..................................	0	42	88	112
+11863	PF12030	DUF3517		Domain of unknown function (DUF3517)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3933 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 340 amino acids in length. This domain is found associated with Pfam:PF00443.	25.00	25.00	39.90	27.20	23.30	22.90	hmmbuild  -o /dev/null HMM SEED	337	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-12.04	0.70	-5.89	7	66	2009-07-08 14:28:27	2009-07-08 15:28:27	3	3	65	0	54	70	0	333.30	29	14.32	CHANGED	DYFEhLh.LAsFGshEsthlLppGFLLKCLEIlWLD+EDSKRL+RQYhsYh+LlEKGR+FSHRKLh-LLuhLLs+IDhTssPos-DcR+sLPsG+aoLThoEsshlRPL.GRspELslL+KlLpQ.ssPpAsRsIVulhlDAEPEAGLhDPICKVLE-GLRluP.AcLCAPFLEATLIFCpRSPDc-RIVuLIDaVAKGV-SINDSGG+EHLAFFTulhssRNERLuL-EsWFLSpllD+IPDWAPTLLhaPDRsVRNMTh-hL+pILFosEAp-hs..-DaQsRau-lAKELV+ASl-+LRKsaLssPGssVEs+sl..Eol+sVI-HCLsoYF.sDSE-DQ-	......................................................................................................DYFthlltlAphGthEsthlLpc.GFLh+.sL.cllhhD..pcs......o.p...cLpc.pYssh.h+.ll..p...K...sRphS.....atp.LhpLLshLlsp....l....D....h....sh..s.........P....s......s....s....s..pp.....c.....p....h....t.....s.....s..+...a..........sl...........Ths..E.spll.p.s.h.s+p.p..s.h.hhlcKlLp.ppsstso+....pIlshllst..p...sph..sL..t..-sl.h+sLccGlpspP..upL.ssPFLc.A..sLlFCptusshsplpsLIcalscsscS...lss...u......s......GcpaLsFapslh.ss.c.Npp.h..ttsc..t.hhhstl.l-plPcWAPsLLtasDc...sVRssT.caLpplLF...........s........t.....p.h......p....-.h...s...-.....-.......h......pp......h..h....pc....h....u+pL......upsClp.....hL+csals..s.s...s..p..l.pspsh.pslphVlppChthYF.sptp.......................................................................	0	7	24	41
+11864	PF12031	DUF3518		Domain of unknown function (DUF3518)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3830 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 260 amino acids in length. This domain is found associated with Pfam:PF01388.	40.20	40.20	58.30	43.20	29.50	23.90	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.77	0.70	-5.58	6	191	2009-09-14 14:01:10	2009-07-08 15:30:20	3	4	82	0	96	173	0	241.10	64	14.63	CHANGED	DSLAKRCICVSNIlRuLSFVPGNDsEMu+HPGLlLILGKLlLLHHEHPcRpptPtTYp+EE-c-pGluCS....K-EWWWDCLpsLRENsLVTLANISGQLDLSsYsEoICL..PlLDGLLHWhVCPSAEAQDPFPTsuPsSsLSPQRLVLEsLCKLSIpDsNVDLlLATPPFSR.EKLassLVRalGsRKs.VCREMuVsLLSNLAQGDstAARAlAlQKusIGsLluFLEDulshAQaQQStHSLhH.Mt..sPsh-PsSlDMM	.......................DSLA+RClCVSNIlRSLSFVPGNDhEMSKHPGLlLILGKL................lLLH.HcH.....PE....RK...pAP...TY...E.KE..E...-....p..DpGVuCs.........................KsEWW...W.DCLEhLRENTLVTLANISGQLDLSsYs.ESICLPlLDGLLHWhVCPSAEAQDPFPT..lGPNus..LSPQRLVLETLsKLSIQDNNVDLILATPPFS..R..EKLYuoLVRaluDRKssVCREMulsLLuNLAQGDoLAARA.IAVQKGS.IGNLluFLEDulshsQaQQSQpuLhH.MQ..sPshEPsSVDMM..........................	0	25	33	60
+11865	PF12032	CLIP		Regulatory CLIP domain of proteinases	Mistry J, Gavin OL	anon	pdb_2ike	Domain	CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively. [1] [2]	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.19	0.72	-3.87	120	622	2009-07-08 14:42:14	2009-07-08 15:42:14	3	13	68	4	294	670	0	53.10	30	15.22	CHANGED	CpsP..ssp.sGpClslppCpslhpl.hpp.....p.hsspctpaLcp..upC..Gh.....tss.pshVCC	.............ChsP..s..sp.sGpCltlppCs..lhpl..lpp.....p.hss..pptpaLpp...upC....Gh...............tss.pshVCC..................	0	55	100	249
+11866	PF12033	DUF3519		Protein of unknown function (DUF3519)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2444 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 117 to 1154 amino acids in length. This protein has a single completely conserved residue Q that may be functionally important.	27.50	27.50	28.20	27.70	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.53	0.72	-3.85	10	158	2009-09-11 06:57:10	2009-07-08 16:12:16	3	3	48	0	3	164	0	96.40	26	22.41	CHANGED	ll-phsKl-cpst.hAhcapN....l+lslpcppsspclhsaa..puacchh-ss.hhpsSsh.......hsttphpshsuscsNPTsKPLTSQEsL....LKsoENLNEsTsEsspLSP	..........................llcph..+.h.cp.tht.hAhchtN.....h+l.s.lpsphssppL.saa..puac....hp.-sphhhphpsh..........htttt.hps..hs.scs..NsTpKsLpoQEsL.........hpppct.tp.............................................	0	2	3	3
+11867	PF12034	DUF3520		Domain of unknown function (DUF3520)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3604 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 180 amino acids in length. This domain is found associated with Pfam:PF00092.	25.00	25.00	34.10	31.40	19.50	17.70	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.16	0.71	-4.16	49	418	2009-07-08 15:16:07	2009-07-08 16:16:07	3	13	396	0	115	369	71	179.40	45	30.57	CHANGED	uTLhTIAKDVKlQVEFNPApVucYRLIGYENRhLscEDFsNDpVDAGEIGAGHsVTALYElsssusts........h-sLRYtt.......stts..........sstssELAhl+lRYKtP....suspSpLlphsl...t.tsshspuSs-h+F..AuAVAuFGphL.+sucah.......sshsasplh.sLApsutGp..DthG.........YR.sEFlpLlc...hApuLp	.............................tTLhTlAKDVKhQlEFNPuhVsEYRLIGYEsRtLpsEDFN.NDpVDAG-IGAG+pVTALYEls.sGppup.........lDcLRYt..................sptss.........sspssELAalKlRaKtP.............pup..cSpLl-.hPl......s.ssh.spsS.cDhRFuAAVAuaGQhL.RuScah........sshoasplhphAppupGp..DstG.........YR...uEFl.cLlchAcsh.s..........................................	0	48	77	96
+11868	PF12035	DUF3521		Protein of unknown function (DUF3521)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3612 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 42 to 74 amino acids in length.	27.20	27.20	27.30	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.57	0.72	-4.11	23	1098	2009-09-11 15:50:18	2009-07-08 16:24:58	3	4	252	0	1	353	0	30.30	39	57.64	CHANGED	MPDAhphuu..hpthspllsh...ttaVGphRRs+php.+	...........MPDAhhhsu...hpsh...p...phhp.......ht.hRps+thp.c......	0	0	0	0
+11869	PF12036	DUF3522		Protein of unknown function (DUF3522)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3665 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 220 to 787 amino acids in length.	25.00	25.00	27.10	26.90	22.40	24.20	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.25	0.71	-4.50	24	294	2009-07-08 15:30:14	2009-07-08 16:30:14	3	4	111	0	167	260	2	162.00	32	30.55	CHANGED	.ttthhtslhhslSslshlPslhhsh++pahhEuslhhFshhhShhYHuC-shss.hh.....hshhpachLp.hshluuhhuhaVplhshsthsp.hcpslphhshhhhhlhttts.hshh.hlsPlhhulhhhlstahhc.t+tpphhstphh...........................hhhhhhssulhhhhhuLs.....-spDsYthhHo..hWHh	..........................h....hhtsLlLsLSNLhFlPslhlul+ppa.hhE...uslYhaoMhFSshYHACD.tss..h..........hChhpachL......p....a......hshh...uohhuhaVol.h..shup..hpthhctshhhhshhhhuhhhthst.h...s.hhshhhPh.hhuhhlhhs..t......ahhc..hc..p.+phassphh..............................................................................................................................hhhhhlhs.Ghhhshhu.l.h...hp..sp.....-sYhhhHS..hWHh...........................................	0	45	67	110
+11870	PF12037	DUF3523		Domain of unknown function (DUF3523)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3746 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 257 to 277 amino acids in length. This domain is found associated with Pfam:PF00004. This domain has a conserved LER sequence motif.	25.00	25.00	29.40	29.30	23.30	23.00	hmmbuild  -o /dev/null HMM SEED	276	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.84	0.70	-5.42	14	270	2009-07-08 15:33:07	2009-07-08 16:33:07	3	5	136	0	167	233	5	216.40	41	43.44	CHANGED	PsPPussussssssp.............t.tshsusFDPoALERuAKAL+pL-pSsaA+cAhELhKhQEpT+QtEhpschcchpAthuphpsE+tRl-t-E+RKslpppsppcptpupYcDcLuRcRhpccLppQcppNpE.L+pQEEush+QEthR+pT............ccEtcLc+cNhht+lcAEscuRh+tcRcNcDlphchl+.+usEcRcThlEuIpTshuhlGsGhpshLoDpsKlshsVGGlThLAhGlYTs+pGstVshpalEppLG+PSLlR	..........................s............................t.t.t..tFDspuLERuAcAh+plppS.pA..+c.............shpl.phQEtTh.QhE.pschpchcsthtphc...-ph+hptEEc............RKshpppspppptpApYpDpLuRpRhp.............c...........phtt.............Qphh.pp-.l+hQE.ESs.+QEthR+tT......................hccchcLc+cs.hh+hpAEscu+A+tpRpNtDl.hcpl..+h+AtEcRpThl-uIpTshsh.hGt............GhpshloDhsK.lhssVu.GlThLAsGlYou+pustVstpalEttLG+PSLVR..........................	0	62	89	134
+11871	PF12038	DUF3524		Domain of unknown function (DUF3524)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3749 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and eukaryotes. This domain is about 170 amino acids in length. This domain is found associated with Pfam:PF00534. This domain has two conserved sequence motifs: HENQ and FNS. This domain has a single completely conserved residue S that may be functionally important.	25.00	25.00	25.20	25.10	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.07	0.71	-4.70	31	155	2009-07-08 15:36:23	2009-07-08 16:36:23	3	6	115	0	73	154	105	154.80	47	44.42	CHANGED	M+ILlL-sahuGSHppatctLhpp...pa-hplloL.PuRtW+WRhRGuAloau...pp.hhtpppa...DlllAToMlDLAslhuLpP.pLup....lPtllYFHENQhsYPhss......spp+chpashlNlhSALAADtVlFNSsaN+cSFLsulpshLc+hPDhts.tshlcpIttKupVLsssl	....................MpILllEsFaGGSH+plh-hLtcpl....t....-hslhTL.PA++W+WRhRsuALhFu....pp..lshsppa......clLhAoShLsLspLhuLpP.cL.up....hcpllYFHENQLsYPVpc......spcRDhpauasplhSsLsADhVlFNStFNh-SFLsulspFh+hhPDa+P..psltphIcsKspVlahPl..................................	0	26	37	53
+11872	PF12039	DUF3525		Protein of unknown function (DUF3525)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3833 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in viruses. Proteins in this family are about 360 amino acids in length.	25.00	25.00	334.60	132.90	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.57	0.70	-5.98	2	191	2009-07-08 16:05:37	2009-07-08 17:05:37	3	4	4	0	0	133	0	144.50	43	73.73	CHANGED	LlFEPVTRGKaTF.YPFGHWCLRDTNSMIlYEG+FVs.ctTSlGs.FKLoKShRPl+sGtshHLVPFHlQKLLDSMD-cs.PYSAsHNCTTVILcuIMYRSslGFlFAYulSWAVYhVLRPPQhAATsYpWhaPERoWDpS+hYphLGFAAGGTlPMEhlDpE........P.E-c.S................................DsuRo...s-ND.................................................cQ+cs-h.pEWWhSpDSlcsVpNDlhYhLSFL+sTsIPE-l+L-lVELsYsQhscDEccRIPEP.GT+ILsMPsW+PsNWA+LIDETHRVLSQFopYsPRlLNEhssWL+GLupNLYRVsEPIL.LLlRAMRAAhoVSpRAsRSlYpChCHWLDVMYGGSAPpRlKTVWGLTGhIsSGMTSQ	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	1	0	0	0
+11873	PF12040	DUF3526		Domain of unknown function (DUF3526)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3851 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 149 to 170 amino acids in length. This domain has a single completely conserved residue P that may be functionally important.	25.00	25.00	35.80	34.00	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.69	0.71	-4.08	38	152	2012-10-03 10:13:34	2009-07-08 17:13:32	3	4	74	0	62	180	55	155.60	23	34.11	CHANGED	oph-hshsl+...csh......csssDhthpthtpphlppas.ptscs......LPh.saphhh...hhtscphssphhsphhcphhpthtpQpplschhuhlSPslulpphspslAGTDhtpahcFhppsEpa+tphtphhst.................stshpptphssspaptlPpFpap.	...............................................th-hshthc...csl......pss.D..htphhpphhtpas.ptscs......Lss..sachhh...hhttcphssphhsthstphtpthtpQptlspthuhluPslAlpph.hpLAuTDhtsphpF.pps-ta+tpltphh...................................................sthhpcpthss.scapplPpFpap............................................	0	24	41	48
+11874	PF12041	DELLA		Transcriptional regulator DELLA protein N terminal	Mistry J, Gavin OL	anon	pdb_2zsh	Domain	Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins. [1]	20.70	20.70	20.70	26.70	20.20	18.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.64	0.72	-4.32	20	463	2009-07-09 08:13:55	2009-07-09 09:13:55	3	4	232	2	35	475	0	60.40	62	14.67	CHANGED	DELLAVLGYKVRSSDMA.-VAQKLEQLEhVMuss.p-DG.lSpLuoD.TVHYNPSD..LSsWlpSMLoELN.P.ssssstss	......................s-hh.-VAQKlEpLE.sh.s....................t-DG...lS.......pLASD....TVHYNPSD..LSoWLESMLSElN.s.ssp....s.s.......	0	7	24	29
+11875	PF12042	RP1-2		Tubuliform egg casing silk strands structural domain	Mistry J, Gavin OL	anon	pdb_2k3n	Domain	Spiders use fibroins to make silk strands. This family includes tubuliform silk fibroins which are used to protect egg cases. This domain is a structural domain which is found in repeats of up to 20 in many individuals (although this is not necessarily the case). RP1 makes up structural domains in the N terminal while RP2 makes up structural domains in the C terminal. [1]	21.10	21.10	24.00	21.30	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.27	0.71	-4.60	17	225	2009-07-09 10:00:34	2009-07-09 11:00:34	3	18	29	3	0	228	0	156.70	38	69.36	CHANGED	susupuuSuuuuuus.......uSAFAQu.hSuuLusSSsFusAFuSsoSsSuuuslAhpluhssApoLGl..ususALAuAlupAVuuVGs.GASusuYAsAlusAluphLuspGlLs..uuNAu.ulASShAsAlououuosu................utuputuuuSuhtpuuopouupoAus	.....................................sutuuutuuu.tuu.......uSuFupu..uuuLusSosFs...osFuSu....sS.tSssusluhphuhssAsoLGl..ssusulAsAluQA.VuuVGs.GASutuYAsAlusAhuphLuspGlLs..suNAu....oLASShASAlouSAuSsuush............ssu..tusupu....tuuuu.uhtpsuopSuutut..t...............................	0	0	0	0
+11876	PF12043	DUF3527		Domain of unknown function (DUF3527)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3945 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain has a conserved CDCGGWD sequence motif.	25.90	25.90	60.30	44.70	25.40	25.20	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.49	0.70	-4.91	12	128	2009-07-09 12:13:05	2009-07-09 13:13:05	3	4	19	0	91	118	0	219.60	24	44.32	CHANGED	SsophpuhLphshK.NGhPhF.Fslcs.c....-lhsAshh+ss.......sshshhYTFaohtt..++psuuhhsttp...p......lVGQMpVSs.hs.p.ttpt......hhpEFVLas...t.upp................p..ps.h.pt.t............p.....t...p.hptp..........sh.ps-LpssLElAAlVl.p.s..hpppps...................................h.tpSstsspV..llPuGhHGhPpst..uPSsLIpRW+SGGuCDCGGWDhuCsLtVLssttpps..pp.h.......tppsh-LFhpGspcps...PuLshsslc-GhYtVcFcupLSsLQAFSIClAhlHspc	....................................s..tuhlph..c.ps..hF.h.htt.p.....t.hsAp..p.s........tt.p..Yhha......p+tpt...t.............hluphpsSs....p.t...ttt.......h.pEaVLhs.......t....................................................................................................................................p.Eh.Ahl.t............................................................s..phpl..lhPsG.Huhsppt....tPssLlpRW+pGGt.CDCGGWDhuC.lhlLts...tt......t...................p.hcLhh............puttpt....shhphh.htpG.a.lpFpup.lo.LQuFuhslshlpsp.........................	0	12	57	73
+11877	PF12044	Metallopep		Putative peptidase family	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3942 (release 23.0)	Family	This family of proteins is functionally uncharacterised. However, it does contain an HEXXH motif characteristic of metallopeptidases. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 625 to 773 amino acids in length.	25.00	25.00	25.90	25.50	24.90	22.80	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.25	0.70	-6.02	28	198	2009-07-09 12:24:12	2009-07-09 13:24:12	3	6	159	0	150	210	5	375.90	31	58.75	CHANGED	shclhNlp-sph.VppsslllcGpssstp.....tssslpVppssp...t.aPshs..a.....................sVssup.........FKAllhLs..PGt.Nplphp.........h..........sssspsphlslpYpPhhps.Pl+Lslllu+DSstpaDusstphp..pptsssL-tAI+KlRhuuhLhQAFTsEpMhcsGaGpRoFpFpEEhphssh..........ps.h.+sph....KlHllRSc+TltElRc.slAQQNspupcsstLFshsh-slcphst......psspthpsushhLDo+aDs...ptp.............hIpGHAALGGGssp.lpLAIFGSHuLaSWPsshEpl.sssFpDsTpsssscVANDsNcsGThWEshslslGAahHElGHhhGsPHQps..GlMLRsYsp.h...NRoFhs+EshuhRocopG.....s.hhPpscC.....pWpRLDhLRFhhHPsFpLPtD...................sh.s.ssssha......shssst..shlsussGIh	....................................................t..pl.shppsph.l.p........hlllpGphsp.p................hsthlplpp.ps..........t.hPshs...a.......................Plp..s..up.........FKAllhLs..PG...Nplphp............h..................ss.psphlslpa.h.Phhps.....PlpLslllu+DSstp..aDss.tp.t..pp.sssL-sAl+KhRhuAhL.hQAaTuEpMhcss...............hGpRsFphpEEhphssh...............ps.h.+pph.....+lHllRop+TlsE.lRs.p....hsQQt...p.....upsps.tLaphshcslcphht......tstpp.hsushhLDo+aDsptp.............hlpuHAALGuussp.lpLAl.FGSasLaSaPssh-cl.sssFhDsT.pssss...VuNDsscsGo.WEshslslGAahHElGHhFGsPHpps...GlMhRsYsh.h...NRoFhs+EshshRspppG.......................t.hh..tpps............tWpRLDhlRFh.hHPsFplPtD....................h.sstt.pha......shtsst..hhhhs.sGl......................................................................................	0	38	74	127
+11878	PF12045	DUF3528		Protein of unknown function (DUF3528)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3981 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with Pfam:PF00046.	29.50	29.50	37.60	37.00	27.60	26.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.12	0.71	-4.06	29	255	2009-07-09 12:25:28	2009-07-09 13:25:28	3	3	89	0	82	221	0	140.80	51	50.90	CHANGED	sDFSSlPSFLs..psSSpPhTYsYS.SNL.PQVQPVREVsFRDY.GlDsSsKW.HaR......................GshupCY...........uuE-.lhHRDsLsssssh...uEhlhKN...su..ssh......Hsuos....uo.osFYusVGRNGVLPQuFDQFF-TAYGsu-s.sss-.hsssKsss+h...sssss	...............sDFS.olsSFLP..psoSp.hTYsYS.SNL.sQVQPVREV..o.FR-Y........ul-s.usKW.HaR.........................G.NhupCY...........S.uE-.lhH.RDCLsss.os................u-hLhKN.su..shh............H.uust.......so.osF...YosVGRNG...VLPQuFDQFF-oAYussps....sss-...stpKsttph.....sst......................................	0	3	11	38
+11879	PF12046	DUF3529		Protein of unknown function (DUF3529)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3346 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 176 to 190 amino acids in length.	25.00	25.00	27.80	27.30	22.60	21.60	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.88	0.71	-5.24	26	113	2009-07-09 12:27:30	2009-07-09 13:27:30	3	2	104	0	56	112	148	165.90	36	87.39	CHANGED	.ssshhSTLlLTlLLuIGLhFFlRAusKDRTshhclh....Ssps.......shplhstlppahcpRuaphsssDscppllpFcGtVtsShhLAlhLohLuulGhsCLGLVlp.LhPphuhW.lh.LslLu.PLAGhaYhp+ApR.Eplcl+Lhsss.pss.............sSplplcAHRDELh....pLtcsLpLpucG	..........ssh.oTLhLslL.slGLaFFl+uSsK-Rhpphphh....ssts..........tplhsplpsaFppRuaplss.p.ppphlsFEGhVtsShhlAlaLohLsslGhssluLVLshhhPs.....hu.......hhhh.LshLu.PLAGlaYWp+AuRhEp..lpl+lhsss...sts.............tStlplpuHRDElh....pLpcpLpLppp...........	0	15	40	52
+11880	PF12047	DNMT1-RFD		Cytosine specific DNA methyltransferase replication foci domain	Mistry J, Gavin OL	anon	pdb_3epz	Domain	This domain is part of a cytosine specific DNA methyltransferase enzyme. It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties. [1]	20.70	20.70	21.20	20.70	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.64	0.71	-4.50	38	305	2009-07-09 13:01:57	2009-07-09 14:01:57	3	35	122	5	168	317	0	136.40	27	11.89	CHANGED	tcshPp+pLssasla-.scuchpsl-hh.hc.sh-l....ahoGhh.tsht......-sp..............sp.pt.............tuhpspu....lup......IcpWtIshh-..sut.shlhlsTshApYcLhKPuppYt.ha-hhhc.+splshtlhchLpcss....choh--llstltpt	.....................................................pthPp+plssaslas..pc.............u.chhsh-hh.hc..sh-l.....ahSGhh.pslh..........cpp..............sp.pt.................Ghps.cs......hus................IppWh.I..shhc........sut.sllsloTs.....hA.t.YhLh........cPoppYtsha..shh.c.+hhluhhllchLpcss.....choac-lls+ltp.s.............................	0	57	94	132
+11881	PF12048	DUF3530		Protein of unknown function (DUF3530)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2450 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 272 to 336 amino acids in length. These proteins are distantly related to alpa/beta hydrolases so they may act as enzymes.	29.80	29.80	31.40	30.30	29.30	29.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.88	0.70	-5.44	36	175	2012-10-03 11:45:05	2009-07-09 14:03:12	3	2	157	0	59	189	50	266.50	22	94.97	CHANGED	hhhthhLhhhhhhshh.......tt.........stptss.tss........................tt...............hpchLPs...................sEhptLps...sscphLsLhcstpsup.pGsllllsstspsADhsshlu.LRcpLsctGWsolSlo.Ps..........t...shh...ttsttsssssstp.ss.spp...........s..t.t..........................................phhptpp.......pplhsplsshhs..hspptsup.llllupGpuAshshchLupppssp........ss...................sLlhlssh.......hPsptt......tsLsphlup.lplPlLDlatss.pshshpsAt.....pRcptup+tpp.sYcQhtLht.....ss.ssppp...lhpplcGaLpphs	.................................................hs...................................................................................hpc.lPt............................................pp.p.lps.....ssppalsLapstpssp..GslIllsstspssDhsthlu.LRcpl.sshGWsoLolshPs.................t....h..........tsttsssssttt.ts.ttt..............................t...............................................................................................p..pspt.......ptlhsplpushs..hut.ppt.sc.llLlupGsuAhhshchluppp.st....p...................sLlhlss.........stptt.........sL..ph.lsp.lplshhDlh...hts.tsh.....stpsAt.....tRhphup+tptssYpQhsl.sh........s..s..psppp...lhpplcGWlpt....................	0	14	27	45
+11882	PF12049	DUF3531		Protein of unknown function (DUF3531)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2583 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 149 to 199 amino acids in length.	25.00	25.00	34.50	32.00	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.73	0.71	-4.53	21	130	2009-07-09 13:05:26	2009-07-09 14:05:26	3	3	98	0	64	130	123	144.70	44	69.87	CHANGED	McVpFREhsPFssWIWLcFussPopsE+pYl-plFcSWalLG+LGGFNAENLQlpEsGsDlSaMsYDs-ps....sushsALMHNMG-hEYpspWARCWhDLGTSDulALDVLINALpQlsp-hVpIccllIGG.N.EDWPlp..-pt-sh......Fsp	............McVpFR-FsPhs.sWIWlEFts.sPoptEhphlcplhpSWallG+LGGFNupNLQlp.p.suhD..h..uahsYDs-pu.....ssshsuhhHNhG-lEaQssWuRsWlDLGTSDhluLDVLINuLpQlSs-aVsIcplllGGpN..pDWshp.spp-....s..............	0	13	42	57
+11884	PF12051	DUF3533		Protein of unknown function (DUF3533)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2348 (release 23.0)	Family	This family of transmembrane proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 393 to 772 amino acids in length.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	382	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.16	0.70	-5.71	39	601	2012-10-03 10:13:34	2009-07-09 14:10:01	3	6	468	0	205	969	15	280.00	21	43.58	CHANGED	shllLslhhlulhu.lYWGuhYppss+h+slphllV.tDs....s........tt..shlGssltshhsph.s............thss..aplhs.scat...........hspclhchlacp+YWuAlhlpsNATpsLhsul..ssusssasso..shhphlapouRc.oshsohlhs.lptlpphhht..hssphl..plhpshsshspsshht......hlssshsashhDh+PhsssshhussplGlIYhlIloFFp.........hshhssl+tph.....tphl....+htph......llaRhlsShlshFhlSLhashlo.huFplsF...................shsa...G+.uGFlVaWMhsaLsMtAlGhssEshshll....sP.aluhaLlhWlIlNlus..shhPhsLs....PsFYRaGYAh.PlHsshclh+sI...aasspp.splGhshGlLhAWlslshh	.........................................................................................................hh.................h.s...........h...s.....u....h.....a.....c....s...h.....s...phpp...l.lAVVNpDpG.............tt....s...s...lG..s..sh..s.shl.pp.ps..............hcaphh.......................................spccs.pctlp.pucYauulh..IPs.s.........hopplts............sl.......pst...p....s..s....hphp..................sssph.l...h..s.sup........t...s.s...h.......p.....p.........h.h.t.....p.h.h....p....slppshhp.....phsp..th..h.........s....l.psh..ss..................................................................................................................................................................................................................................................................................................................................................................................................................h....................................................................................	0	50	115	181
+11885	PF12052	VGCC_beta4Aa_N		Voltage gated calcium channel subunit beta domain 4Aa N terminal	Mistry J	anon	pdb_2d46	Domain	The beta subunit of voltage gated calcium channels is coded for by four genes 1-4. Gene 4 can produce two types of beta4A domain (beta4Aa and beta4Ab) according to how the gene splicing is carried out. This family is part of the beta4Aa N terminal domain. It is made up of an alpha helix and a beta strand. It is thought to regulate the channel properties through protein-protein interactions with non Ca channel proteins. [1]	25.10	25.10	32.50	35.50	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-8.10	0.72	-4.09	8	450	2009-07-09 15:44:57	2009-07-09 16:44:57	3	7	87	11	136	407	0	42.20	78	8.59	CHANGED	GSADShsS+PS-SDlSL-E-REu.................LR+EsERQAtsQLE+AKsK	......GSADSYTSRP.S.DSDVS.LE..E.DREA.................lR+EsE+QAtsQLE+AKoK..	0	16	28	69
+11886	PF12053	DUF3534		Domain of unknown function (DUF3534)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2753 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 150 amino acids in length. This domain is found associated with Pfam:PF00595. This domain has a conserved GILD sequence motif.	25.00	25.00	25.20	25.00	24.50	23.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.82	0.71	-4.32	7	242	2009-07-09 17:29:17	2009-07-09 18:29:17	3	9	78	1	93	240	0	108.90	49	11.13	CHANGED	MKV.TVsFG+TtlVVPht-up.pVppL.........lppAs.RYt+spsptst.WlpVa+LE.asDGGILD.DDlltDVs-.D+DpllAlaDE...Q-s..tpGG-usSusSs......sppSP-.apsEhusp..huAFpPh..tuEI-VTsos.L+h...uhPLhVR..RSSDP	.....................................................................................st......hlpl.p+Lp.....spG.G.ILD.DDhltDVs-.D+-.......p.L.lAVF-E.....Q-P........ppuGDu.sS..uSSo.......GTQSP-h..FtsElusp..........huA.FpPh.......suEIEVTsSs..L+h...shP..LhVR..RSSDP.............................................	0	25	34	62
+11887	PF12054	DUF3535		Domain of unknown function (DUF3535)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2858 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 439 to 459 amino acids in length. This domain is found associated with Pfam:PF00271, Pfam:PF02985, Pfam:PF00176. This domain has two completely conserved residues (P and K) that may be functionally important.	26.20	26.20	26.30	27.90	25.70	26.10	hmmbuild  -o /dev/null HMM SEED	441	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.27	0.70	-5.86	32	289	2009-07-09 17:31:25	2009-07-09 18:31:25	3	20	241	0	212	284	4	412.50	26	24.30	CHANGED	VWpsLlpph.....s.pslssthssalpshlpLhhsPhGh.h.shsh-sslll+PSut...................thpstcpcptpptptt.....s.ts...ph.DsthhtG-lpllGhD......sllRsRltAA+AlGhhhuhh...spssltshhps...........hLhstLsSstusp+hluulllscaspstt.ppsts.................phhsttLhphLp.....t....p.shYcElsshl.ptlRspCpsLlsohtssuh.h....pls.lshhspupspssspuFol-sAcclssph....apchtpthsssp+l........uhpsLE-sRpplhsulpps+p..scpphcsplhuuhAuAllshpsLPcKLNPlI+sLM-SlKcEEsthLQp+SApulupLlp.hst...st+ssPssKll+NLCsalCsDooETPchs........................ssphppsILoLt......+cpspts..........................hssssphpcpscpApIpR+GuphulpplsppFGsplhsplPpLtshh	.........................................................................lW.tLlpph.....s.thl.....t..th.tsa.htshlpLhhpP.tl.....shchs.hhhcssutsh........................................t.tstphp.t.pttttt................t.....stp......h.h.ush......p.hl..s.-...........slh+uRlhAAcALGhlhshh.......spsshtshhp...........................................hLl.tL........sS.uuhp+lssuhlls-aAp.tttppshs............................................................................hlpttLhp.hLp.....................................c..hYcElss.h.pthpspCppLlsshtstsh.........................psp...sps......sss...sholc..pAp.clssp.........apchppshs..s..+h................................hp.LpspRpp...l.hslppspp...ppthphplpushAuAlls..........h..p..........tl..P.cK...LsPlI+slM-olKcEEs.t..LQphuAp.slApLlp.hs.........spp.sPssKllpNLsshhCsDsspTPphs................................................hpsthppsILoLh..............+cppttt......................................................................ts..sp.h..pctt.ct..ut.lpRRGAp.ALpplsppFGsplhpclPpLhphh..........................................................	0	67	112	174
+11888	PF12055	DUF3536		Domain of unknown function (DUF3536)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3129 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 274 to 285 amino acids in length. This domain is found associated with Pfam:PF03065.	25.00	25.00	39.30	39.10	18.70	17.90	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.78	0.70	-5.24	23	127	2009-09-11 10:41:18	2009-07-09 18:40:01	3	5	114	0	74	140	17	241.30	31	32.54	CHANGED	WsQp........WRsPLRcALDWLR-pLAthaEppusthhpDPWtARccYIcVlLcR.s.-shpsFltc+stc.lstc-plpsL+LLEhQRpuhLMaTSCGWFFDElSGIEoVQllcYAuRAlpLAc-lss.sh.EscFlp+LppAhSNlsphusGsclYcthV+PuhlsLhc.VuAHaAlsSLapshscps.hasYplt.cphchhtuGpsplAl...G+htlpSphThEptphhasll+hGsashpsGVp.apsppsatphhpplhttappushstll+hlsccFutpsYoLccLFp	.........WpQp........WRtPLRpAL-hLR-plstha-ptutth..h.p...D.PWtARc...cYlpVl........hsc......s........p......shppFltc.attp.Lstpcph..psL+LLEhQRtuhhMaTSCGWFF--lStlEslQhlpYAtRAlp.Lupch.......ss...........p...l....-tpFlptLtpA.SNh.p.htsGtplapphVhsshhsh.p.luuphA.lsslhpt...h................p..................t..thhs...apht..thp.....st..thhh..Gph.h.s.hT..pt..h.hssh.hGt.p..s.h................h.....t.................................................................................................................	0	33	59	68
+11889	PF12056	DUF3537		Protein of unknown function (DUF3537)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3199 (release 23.0)	Family	This family of transmembrane proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 427 to 453 amino acids in length.	25.00	25.00	32.10	26.00	21.30	24.60	hmmbuild  -o /dev/null HMM SEED	398	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.39	0.70	-5.76	9	121	2009-07-09 17:42:07	2009-07-09 18:42:07	3	3	18	0	83	119	2	332.00	35	86.54	CHANGED	psscELt....pFcshLpWhshDpSs.hssslSW.lFhlLullVPhlu+hLLsCt....sC-.hppRsa-shVQlSLShhAuluFlsLSchhR+aGlR+FLFlD+LhscSp+VRhsYssclppSh+lLuhalLPCFsscusY+.IaWYhou.sphPalhpshhupslAChlph.sSWhYRTolFllsClLF+LlCaLQlLRh--FA+hF.....ptps-ltslLtEHl+IR+pL+hISHRFRtFILhsLllVTASQFsuLLhTT+sputlslhpuGELALCSlsLVoGLhICL+SAsKITH+AQulTulAo+WHsssTlsSh-ph........poPsus........hss..shp.ssstsssssEpsst....-DshcsTcI..hP.asp.shSaQKRQALVoYLENNpAGITVaGFhlDRoaL+TIFhl	..........................cpLp....pFcthLpWhsh-p..Ss....hshhhSahhFhhlulslPhhs.t.hhl.s.............s...p.csaph.Vphs.ohhAsluahsLophh++...........h.GLR+h..LalD.p.ltsc.otpV+tsYttp......l....ptuh+lLuhhllPshhscssa+.laaa...........t..h.P.........a....h.p....s.......h...pslAhhhth.sSWhYRTslahhsClLF+LlCpLQlLRhcsau+hh.....ptp.u-ltsllpEHhRIRcpLphISHRaRhFllhsLlhlTuSQhsuL......lhsst.........ps.hshhpuG-LAlsShs.lsGlhlsLpuAsKITH+AQulsulAu+WHshsThss.st.........tsPpss............t.......t.......s..pp..ps.-..t......ts.hs.ssph..hs.h...h.SapKRQAL...........VsYLppN.uGITlaGahlDRshLpslFhh...................	0	18	54	70
+11890	PF12057	DUF3538		Domain of unknown function (DUF3538)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3373 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain is found associated with Pfam:PF00240. This domain has a conserved SDL sequence motif.	25.00	25.00	34.40	32.80	22.60	19.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.42	0.71	-10.57	0.71	-4.49	9	155	2009-07-09 17:48:44	2009-07-09 18:48:44	3	2	64	0	55	144	0	110.50	61	11.73	CHANGED	LsEVlQchRpVppRLpPFlpRYa-ILpsssTh-.pssTptREpsQRlhshVuEuLHhLupA.hAlSDLhhsLpsssPRHL.ssRPh.........S.ahssPshhssuhh.lPh.hslus......sVs...housGs	....hsEVLQELpRlEsRLpPFLQRYaElLssAsTs-Y.sNN.p.-GREEcQRllNLVGEuLRLLGNshVALSDLRCNLussPPRHLHVVRPM.........S.H.YTTPMVLQQAA.....IPIQINVGT.......TVTMTGNGp.....................................	1	11	16	35
+11891	PF12058	DUF3539		Protein of unknown function (DUF3539)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3564 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved NHP sequence motif.	25.00	25.00	45.40	45.40	18.90	17.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.07	0.72	-4.16	17	75	2009-07-09 17:50:22	2009-07-09 18:50:22	3	1	72	6	29	75	90	86.10	51	97.33	CHANGED	ssEpYLNHPTFGhLYtVsPss.....-u+-laATLYAQRhFFLVshpspG.........hpFEsIshtDARhhsEhpLpphRRss.opEhpphppl..FcQTFl	.s.sEpYLNHPTFGhLYpVs.ss.....-sp-lasTLYAQRlFFLVshpscu..........spFEsIshsDARhhsE.+LpphRRsG.sp-apphppl..apQTF.....	0	4	19	27
+11892	PF12059	DUF3540		Protein of unknown function (DUF3540)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2948 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 212 to 238 amino acids in length. This protein has a conserved SCL sequence motif.	27.10	27.10	27.10	28.30	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.19	0.71	-4.68	14	188	2009-07-09 18:02:22	2009-07-09 19:02:22	3	2	93	0	49	145	5	162.70	28	85.87	CHANGED	phs.upVtt...tts-shhlhpssGh.hps++AsSCLltPpsGDhV.Ll...........ssss-spphYllAlLpRssssss.tLphsG.clsLcs.tttlpl.usstlcLputp.plshpspchphpupphththpchph.upthpsphtpsphlucphcshhpRlhQpscpuhRpVcpl-pscAtplshpscpshph+u+psslTAcsllKlDupQIHhG	........................h..hupVht...hhss.hhhhht.ts...hpsc+AsSCLltPphGDhV..l............ss..ctpphallAlLtRssssts.tlth.sG..tlsLch........tsttlpltutcplslcst..phshpupp..........................hphlucphpshhpplhptstps.RpVpss-pl+Auphphtscpphth+u+pshlsAptllKIDutQIHhG...........	0	18	30	39
+11893	PF12060	DUF3541		Domain of unknown function (DUF3541)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2172 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 230 amino acids in length.	28.20	28.20	32.50	31.90	19.80	17.50	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.47	0.70	-5.06	17	126	2009-07-10 10:48:53	2009-07-10 11:48:53	3	1	122	0	23	93	2	222.40	66	59.53	CHANGED	sssp.oappsAphI+sshEspLYoLPshhpGHYGlRMYR.ThDsKYusAshsDhhpVssp.shaAsplcpPc.Itthuppclssht.....cs.RuptRhpAhcshPEaLahussLLt.huRhDEaGLpt.scs+LpplL++hDhcphhTD.tMIcAWAAQLAN.VYWh+QLG.tDhVpcahpAFpcsYPDspDpcLsppQatNKlYGMTHhIFAsSEYYQH.Vcpp-aQW	.......sss...hoaptoAsLI+pTYEoQLFTLPuFKEGHYuLRMYRQTLD-KYAAAIhSDLuRVAStLNaFAAEVsTPEQIppYupKRLppYp...cs-DERoQRRasATpsMPEYLYLGlDLLGsMARANEYGL..pH..Kp....DsKLRpVLRRYDFo.YATDcsMIEAWAAQLANQVYWLRQLGEQDVV-sFIpAFRcTYPDp+DscLscQQYGNKLYGMTHIIFADSEYYQHsVSpppHQW.	0	1	6	18
+11894	PF12061	DUF3542		Protein of unknown function (DUF3542)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2032 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes and viruses. Proteins in this family are typically between 516 to 1283 amino acids in length. This protein is found associated with Pfam:PF00931.	27.20	27.20	55.50	30.90	26.60	25.80	hmmbuild  -o /dev/null HMM SEED	402	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.61	0.70	-5.50	6	85	2009-07-10 10:50:28	2009-07-10 11:50:28	3	7	5	0	0	85	0	331.00	57	41.90	CHANGED	hcEhIppTK.EhRApYS.FPpssLsuNcV........shcSPcFVMEhIDsVVtNLssLVKIsDssSh.FV.t..KcpIppVhKELKLLR.FVCFVSN+s.IEPQ.p+pTFas+sLhtAS+hAMVsWLY..hP....uNss.DLsPuEsspLLSDahcMKIKsIpPsIp+..IYIDVLQALKSTh.PpsQpcH......As..uGhVET.pHsL...........hVuLoDQMAshpEMLsLLRDNLIHLPILDLEFHLQDhDoVIlDuGLLlYSLYDhctp.EDsoLE-lNptLthDLP+sIE.IKhhlYLVhQKAFQsNLPRIHGLGYVDFLL+NLK-FQDRYSDS.LAFlKsQLQVIQpEhESLQPFLKsVsEEsHNKa-+..EcCss.lItKAYEVEYlVDAC...IsKcVPcWCLcRWLlDIIcEIssI.KtKlpE	............................................................................................................................................WKclIWKTKQEFRApYS.FPKosLAsNKV........s.tsPcFVMEhIDshVtNlNVLVKINDPsShhFVPG..KEQIEQVLKELKLLRFFVCFVSNKC.IpPQYppoTFYoHALIEASHIAMVVWLa..LPl.YGNtNQDLsssE..VSpLLS....DFhEMKIKsIpPslsp..IYIDVLpALKSTI.PpAQpKH.....sh...uuhVEhPsHsL...........hVGLSDQMAsLQEMLCLLRDNLIHLPI...LD.LE....FH.LQDMDSVIlDAGLLIYSLYDhcGphEDTsL--hNptLGFDLPRNIE.sIKsMVYLVMQKAFp...sNLPRlHGLGYVDFLLKNLcDFQsRYSDS.LuFLKNQLQVIQpEFESLQPFLKsVsEEPHNKhKpLNEDCAsQIIRKAYE..VEYVVDAC...INKphPpWClERWL.DIIEEITCIKAcIQE...........................	0	0	0	0
+11895	PF12062	HSNSD		heparan sulfate-N-deacetylase	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2134 (release 23.0)	Family	This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes.  This proteinenzyme is often found associated with Pfam:PF00685.	25.00	25.00	31.30	26.80	18.20	23.00	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.48	0.70	-6.10	7	310	2009-07-10 10:56:38	2009-07-10 11:56:38	3	9	87	0	174	264	0	383.60	61	55.88	CHANGED	hshsllSlhh.saaLaos..s+t.tpstcsst...phsC..s..hh......P.p.h.s+shc.....sss+TDPpVLVFVEShYSpLGp-IltILpSpRFpY+sElAsG+.slPsLTsps+G+YsLIIaENlhKYlNMDpWNRpLLDKYChEYuVuIlGFhpu.sEcsLhshQlKGFPLalasNltl+DhslNP.SPlL+lT+suchcpGsLPG.sDWslFQhNHSTYEPVLhuph+oscp..s..s.......h.hATVlpDLGLcDGIQRVLFGpNLsFWLHKLlFlDAluaLoGccLoLsLDRaILVDIDDIFVGccGTRhpscDV+ALlsTQNplRshlsNFTFNLGFSGKaaHsGT-tEDtGDDhLLpsscEFhWFPHMWpH.QPHLaHN.ohLhppMhLNKtFAl-HsIPsDhGYAlAPHHSGVYPVH.QLYcAWKKVWslpVTSTEEYPHLKPARhR+GFIHsuIMVLPRQTCGLFTHThFacEYPGG.pcLDKSIpGGELF	......................................................................................................................................................................................................h..hshh.hhh.saal..s......p........................ps....t...........................................s.p.......t..+o-..PhVLlFV.ES.YSpLGp-IltlLEusRFp..YphplAst+sshPsLT.-.....ps....+G..+asLlIaENlhKYlshDuWNRpLLD+YCh-.Y.uVGlI...G.Fh.+s.sE....poL.u..h...Q....LKG.FP...L.lasNl.tL.+DhplNPpSPLLhlT+sschc.GsL...PG..pDWTlF...Q.NHSoYpPVlh.Aph.......pstc.....s...h..s..t...........shhsTV.lpDhGLaDGIQRVLFG.ssLsFWLHK...LlFlDAlu.aLosc+LsLsL..-RYILVDIDDIFVGKcG..TRMpspDVcA...LlpTQp.LR..s...lssFTFN.LGFSGKFaHs.GT-t.EDtGDDhLLp.hcEFWW..FP.HMWSHMQPHLFHNt...S.....sLs-QMhLNKpFAlEHGIPsshGYAVAPHH.SGVYPVH.QLY-AWKpV.WsIpVTSTEEY.PHL+PARaRRGFIHpsIM........VLPRQTCGLFTHTIFYpEYPGGspELD+SIpGGELF..............................	0	34	48	107
+11896	PF12063	DUF3543		Domain of unknown function (DUF3543)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2213 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 217 to 291 amino acids in length. This domain is found associated with Pfam:PF00069. This domain has a single completely conserved residue A that may be functionally important.	26.30	26.30	27.90	27.00	25.50	25.40	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.41	0.70	-5.15	32	333	2009-07-10 11:05:01	2009-07-10 12:05:01	3	7	232	0	217	306	0	231.20	29	26.39	CHANGED	pss..cE-pc..slpplEphAo+u..cslhtFA-VKapQLhPhsP...............ts.s.spssh............psssLsscshhol........ScEuLVLYVKuLuLLuKuMclAusWWppppp......................sshts..Ss+lNplVQWlRsRFNEsLEKAEhl+L+L..pspphLspccsspsp........................sssloAEKLhYDRALEMSRsAAlsELsscDLtG.......CEluYsTAlhMLEAlL-s-..........................stlss-D+phlp+h......lsuIppRLssL+pKht	.................................................................................pEcschlptLp.hhths..cslhthAth+hsth..shss...................................................thttt.s......................................ss.hsphshph...............psEtLVLYlKuhpLLupuh.p.lAtt.hpp.................................................sphss.....Ssplpp.V.Vphlpp+appslppschlph+L....pphh.ccp..hsp.............................................psloAEKLlYs+Al-MspsAAl-Ehhp...p..h..ps........C.hpYppAlhhLEuLhcph......................................................................hctpDpp.lpKh.........................hpsIcpRLssLpp...t..............................	0	55	95	166
+11897	PF12064	DUF3544		Domain of unknown function (DUF3544)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3553 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 198 to 216 amino acids in length. This domain is found associated with Pfam:PF00628, Pfam:PF01753, Pfam:PF00439, Pfam:PF00855.	27.00	27.00	91.00	58.30	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.52	0.70	-4.53	4	139	2009-07-10 11:09:03	2009-07-10 12:09:03	3	9	40	0	32	136	0	190.30	79	18.22	CHANGED	uKPVLuGus....GRRISLTDMPRSPMSTNSSVHTGSDlEQ-sccK......soSSHaSAuEESMD....STASPASsKsG.uGshusSPKPFpspsus...oKQE+ousTGSILNLNLDRSKAEMDLKELSEoV......QpQussssLhSPKRQIRSRFQLNLDKTIESCKAQLGINEIS-DsYsuVEHSDSEDSEKoDSSDSE.hSD-EQKsKNpp-ssps+Eu	...........SKPlLSGGs......GRRISLSDMPRSPMSTNSSVH..TGSDVEQDsEKK......AsSSHFSASEESMDFLDKST......AS....P..ASTKsGQAGSLSGSPKPFS.PQhssP..lsoKt-KT..S..TTGSILNLNL.DRSKAEMDLKELSESV........QQQSs..PVPLISPKRQIRSRFQLNLDKTIESCKAQ.L.GINEISEDVYTAVEHSD....SEDSEKSD...SSDSEYlSD-EQKsKNEPEDsEDKE.G.......	0	1	5	13
+11898	PF12065	DUF3545		Protein of unknown function (DUF3545)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3270 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 60 to 77 amino acids in length. This protein has two completely conserved residues (R and L) that may be functionally important.	25.00	25.00	30.70	45.40	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.12	0.72	-4.22	22	162	2009-07-10 11:21:43	2009-07-10 12:21:43	3	1	162	0	38	93	1	59.60	52	94.82	CHANGED	MDphph....D-llth.-ps...ppo+u+.s.pKRKWREIEAlKD+pRLpKELp-hDhsh-.hsl--...lch	......MDpLca....DEllch.Ehsp.hcpSRoK.P.sKRhWREIEAI+DR+RLcKELh-hDsshD...hD-Ic..............	0	7	14	26
+11899	PF12066	DUF3546		Domain of unknown function (DUF3546)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3237 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 93 to 114 amino acids in length. This domain has two completely conserved Y residues that may be functionally important.	25.00	25.00	26.10	26.10	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.46	0.72	-4.05	19	273	2009-09-11 14:59:35	2009-07-10 12:24:31	3	13	212	1	194	287	0	104.60	30	13.50	CHANGED	oaKpFhts..-Dslscs-uhp+YscYKh-apppQhpcFF.tHK-E-WF+pKY..HPcphsphpccppphhpsphpsFhp.hcsGhhsplpl-ht.t....chhsssllch-sGspp-	................hKtFh.p..--shscs-s.p+YscYKt-apppphpsFFptHKcEE....................WF+pKY......cP-..p..hs....thppctpph...hpsthp.Fhp.lcsGhhDph.l-h..t.....p.hssshlchEtGpt...................................	0	67	109	159
+11900	PF12067	Sox_C_TAD	DUF3547;	Sox C-terminal transactivation domain	Assefa S, Coggill P, Bateman A, Eberhardt R	anon	PFAM-B_3310 (release 23.0)	Family	This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with Pfam:PF00505. It binds to the Armadillo repeats (Pfam:PF00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation [1]. It functions as a transactivating domain (TAD) [2].	25.00	25.00	25.30	27.10	22.80	24.20	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.68	0.71	-4.14	12	166	2009-07-10 11:26:27	2009-07-10 12:26:27	3	4	45	0	80	139	0	182.20	34	53.20	CHANGED	hsshua.aR-htshG..spa-s...YuLPT.PEhSPLDsh-...s-suFFss............ss.pE-sphh.......s.hsYpssas.........pp.pssshh+phshsps...ssst.............shhss.sssthY..uphhss.pst.has.......phG.QhSPPPEut...ph-sl-plpps.-Lhu-lDRsEFDQYLs....ts+s-ht....hsaps..............ss.ssspp...ssL.SlLSDAooAsYYsshss	........................................................................s...tpaR-h.shG......sph-s...YuLPT.P-hSPLDslE......s-.sFFss..........................sh..--pth.............................s..sa..p..s..t...hs......................p..tss....h.tt.hshs.s...ss..........................h.ts..s.ss..thY..sthht............s..............tst..hps..................thG..QLSPPPEs.........sh-uh-php.s..ELLu-hDRsEF-QYLs....tpp..s-hs..........Lshps..............tp............................ss.ssspp.....sul.SlLuDAouA.YYsshs.s................	0	5	10	32
+11901	PF12068	DUF3548		Domain of unknown function (DUF3548)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3247 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 184 to 216 amino acids in length. This domain is found associated with Pfam:PF00566. This domain is found at the N-terminus of GYP7 proteins.	27.00	27.00	27.00	27.40	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.34	0.70	-11.31	0.70	-5.04	9	226	2009-07-10 11:34:16	2009-07-10 12:34:16	3	4	118	0	123	196	0	178.70	30	28.80	CHANGED	ssshKVlFEK-GValHosst+..p-pDshIsGhlRll.EKcu-lhl-WpPlE-.shssstlhhttcsupus............ctscassuYEs-WshloTVshcc+.ttpt....stssspu+W.uFohsLs-L+Sl+ps+.uh...GasYLlhss+cGssLPsLHFHpGGo+thL+sLp+alhLspSPpDu+lhLVhsps.pALSpSF-pL.....--sohsllp+ahpD	.....................................................s....pllapppsValHssstc.....cs.IsGhlpll.....p.....cc......s......p...sh.lcat.....Ph-.-.....s.s..ssthhhs.tps..sps.h.............................................p...sph.ssh-s-W...shlso.....sp.....p..pp.t...p....st.......s.....s.....s..t....s...s..t.u..pa.....uF.s.hsLs-L+Sl+ppc.uh...GW..sY..LVhsh+.sG.ssL.PALaFHpGso+.hlcsLppal.hLspSspDtphhLV.sps......puLspSFppL....pps..s.shh...............................	0	31	49	85
+11902	PF12069	DUF3549		Protein of unknown function (DUF3549)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2034 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 340 amino acids in length. This protein has a conserved LDE sequence motif.	57.80	57.80	86.90	86.80	27.30	20.30	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.11	0.70	-5.66	29	187	2009-07-10 11:52:14	2009-07-10 12:52:14	3	1	184	0	44	152	13	331.00	50	98.51	CHANGED	MspIsTLophLpsussQaplaDlGRRVpcIstppFtpIEptptPYPaPlQpHAphAIsF.W..sts..........pQsaIWFLKLPLDE+GLLp.AsRspFIchllEALGppLspsho--.QQ..ppLusNPYsFKPsp-KhAhFpAhl+tpLspssSpaYEhAtpYLSuph....s......h-sWQslGLQGIADlssRlpppsp.tshltcAlsp....hPtpVhhALstsLEHhs.lscpLu-tlhpphppt......cshhhshhlRALuu..usspshpsh.h.slLsptphhcs-..lLlsIAu...RsWpsL.p-spthphaL-pLAppp..Q....shFsQlFADLVtlPtLRstlLshLRpsspSstLupAIupLFp	....M-sIpTLopLL......psossQYQlFDLGRRVptlDsppFtplEtuQpsYPaPlQpHAphAIsa.W..spp..........+QPaIWFLKFsLDERGLLpQAshupFIphllEAhGscLsp........slo.EE...QQ.....pKLANNPYTFKPo--KlAhhHuplRtpLsLssSQYYEHAQp.YFSGsLG..........W-pWpoVGLQGIsDlCAR............Lpp-pN.ushLc....KALs+.............LPspPLaAlhusLEHls.Ls-cLAc+L.EhspsplttppsDlhLLuAllRALAu....ussshhpsh.hsulL.............sS...stls+sE...VLIulAG...RsWhsL.psssptppFLhRLApsts.Q.....sLFNQLFADlVhlPsLRsshLsLL.cussSspLApAltpL.p...................	0	8	18	32
+11903	PF12070	DUF3550		Protein of unknown function (DUF3550/UPF0682)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2472 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 249 to 606 amino acids in length.	25.00	25.00	27.50	26.70	17.50	20.60	hmmbuild  -o /dev/null HMM SEED	513	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.96	0.70	-12.76	0.70	-5.76	6	181	2009-07-10 11:59:48	2009-07-10 12:59:48	3	4	103	0	130	194	0	376.60	40	82.71	CHANGED	CaLL-KS+pLFNuLRDLPQaG++QWQsYFG+TFDVYTKLWKFQQQHRphLs.chGL+RWQIGEIASKIGQLYYchY..LRTSETsaLsEAFsFY.pAIhsRuYaspss+E-..s-Lhs..K+LRaYARFllVCLLLs+h.chVt-Lspclcphl--hppsapscDptEWpLVlpElsuFlcADs.ltVLpsDphslhhsp.....c.sPhst.Pshtpsshpp..LSLp-uLlhusspsplKFoELTlDhFRMLQsLEtEPssuh.ph...............htpth...t.stpsu.....ltEsuccPshRsNPHKYLLYKPThSQLhsFLusuFKELPsNuVLLlYLSAsG...........................shsos+pst-uPY-hGGlhTusp.+shssGsslphRspu...tKEs.HCLYPGDLhPFTRKPLFlllDSssShAFKshs.shFGQPLlhLLSP..sohPsuhp-p..sp+GSLFThFLpuPLhAFsalsGlu..clctcLW-+sQchLc+hhs-huplLsc.SRs.........lD.salQFhGD-FLRhLlLRFVFCpush+l.H+sF+	.....................Ll-+ucphFstlRDLP.aG....ptp.....pta.Ft+sFcsYT+LWKaQQppR...thL...s.c..hGL+RWpIGEIAS+IuQLYYthY..hRTS-spaL.Eua.FY.tAIhtRtYapp.......s...t.....t...........................cLhl..KpLRahARFllVsLLLp+h.chVppLlpclpt..lp-hpp.pap...p..-.hEWphVlpElttFlcA-s.hh..hps.p....hhhsp....................................t..sh...s.htp...h.t...LpLt-hllhu.tp.pp......lKFoELTlDhFRMLQsLEhEP.t.h.p................................................t.t...........h.p..s...pp...sh..NP+KhlLY+PohophhshLus.hc.....E..Ls.suhlLlYlSAsG.....................................................................................s..pt.p..t..p....s.......p...s..t......t...p................t......tsp.t..........tt....p.laPtDLhPFTR+PhFlllDSpsShsap.................t..h.....t.hGpPhhhLhSP.............t.h..s..hts.........ttpGs.FThFLpsPh.Ahh.h.sls.......ph..thappspthl..tp..t-htt..hlhp.st............l..p.sahphhsD.FLRhLlhRalFCpsshth..............................................................	0	47	68	99
+11904	PF12071	DUF3551		Protein of unknown function (DUF3551)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3610 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 79 to 104 amino acids in length. This protein has a single completely conserved residue C that may be functionally important.	26.50	26.50	34.20	28.80	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.19	0.72	-4.43	37	127	2009-07-10 12:00:59	2009-07-10 13:00:59	3	2	24	0	54	129	3	83.00	30	89.04	CHANGED	MRphhhsshuh......................................shshhhsssssAp.A+D.YPaCLp...usthuas.GcCsasoapQCpsoASGpsApC.......shNPhhs..h..spsppttptp	...........................................hhhhsh.....................................hssshhhss.sssAp..A..t.-..a....saClp........utthuhs..ssCsasohtQCpAoASGp.sAtC.......shNPhas....h..st.tt.....t.................	0	4	14	28
+11905	PF12072	DUF3552		Domain of unknown function (DUF3552)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3508 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 200 amino acids in length. This domain is found associated with Pfam:PF00013, Pfam:PF01966. This domain has a single completely conserved residue A that may be functionally important.	29.00	29.00	29.00	29.00	28.70	28.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.70	0.71	-11.39	0.71	-5.10	58	2218	2009-07-10 12:04:02	2009-07-10 13:04:02	3	6	2166	0	441	1381	168	199.80	32	38.76	CHANGED	hhllhs.llull.VGhslGahl.....RKpluEp+lssAcppAcpIl--A.....................c+-AEshKKEAlLEAK-Eh++hRsEhEcEl+-RRsElQ+.EcRLlQ+EEsLD+Ks-sL-c+EppLpcKEpplttppp.lcppcpcl-pllpcQppcLE+ISGLopEEAKphllcpsEpElp+EtAhhIKEhEpcAKEcADK+A+cIluhAIQRsAADa	.............................................................................................h..llhhllshl..lGh.s...lG....ahh..........................t+...ph....t....pp...p....htpAcppA.c.pI..lppA..............................c...+...EA-....sh....K...KEt..lLE.......AK...E.E....h...........p....chRp.......-.......hE...p.......E.......h....+.......p+...Rp......E....lp....c........E.p....R...Lh....p.......+.......E....c.s....L.-+....Kp-....p....Lcc+.......EppL.......-p+.......cpplt.......p.......c.......tpt.......l.......-p..+cpclc...........clhpppppE......LE+I.......uuLop-EA+phlLpplEc-lpc-hAhhl+-hEp-AK-.cu-KpA+cIlspAlQRhAu-h............	0	198	340	403
+11906	PF12073	DUF3553		Protein of unknown function (DUF3553)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3361 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 60 amino acids in length. This protein has two conserved sequence motifs: GQVQS and TVNF.	20.30	20.30	20.30	20.40	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.59	0.72	-4.65	22	88	2009-07-10 12:12:10	2009-07-10 13:12:10	3	2	88	0	32	90	325	50.90	50	47.26	CHANGED	LEPGhhVRHPspPDWGlGQVQSNIuuRlTVNFcctGKlVIDus+VsLhhVh-	.......LtPGhhV+HPspP-WGhGQV...QS.....slus+l.TVNFcctGKhVI-uspVtL.hV............	0	10	24	28
+11907	PF12074	DUF3554		Domain of unknown function (DUF3554)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2029 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 287 to 356 amino acids in length. This domain is found associated with Pfam:PF02985.	25.00	25.00	25.10	25.40	24.50	24.60	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.88	0.70	-5.01	30	248	2009-07-11 10:07:29	2009-07-11 11:07:29	3	46	204	0	185	264	0	312.50	20	13.21	CHANGED	s-p+slhsphLttl.s.tt.............lSpclspulhsllsKE....uNEsuLsphlsshspahhtl.......psclscclsstltK...Ghs-K+.s..lR+hWhhphsshhh............pstshshsspFhsthhphhccssssPhssspssslsuAalllu.........t..........t...h..hhhs.+sshLhss+haoK.ssps-lpahhcsLpslhsstp.p.ttpt....saupAhlaslsus..phssRcpAhphLpplhtppsth.......lucsllsulhshltshchh............stssshchlphlhpsls.s.sshst..........hcp.hhpLLllup.thls.t.....sWhuLs.+s...plDPupllpcpsc	....................................phl.tls..ts.............lutplsphhhshltcE....spEssLhttlpshshahshh.........pspls..cplhphhtK...GhspKpss..lR+salhphhthhh........................ss.shthhts.llshLhphhccshsp.sh..t.ss..t..ss..th...suAhllhs..............ths..htt.........t...h..pl.h.....h.s...K..ph.hhs..+hhpp.....ssp-shhhh......hchhp.tlhhph.tph.ttth.....pthtpAhlhhlhut..shp.lRcpA.hp...slpplh.tp.sth...........lups..ll.ptlhph.lpshchh..pt...............ttssptt..p.h.hh...s.pslp.s...s.hpt...........t......hcp.hhphLllu+p..l..sts........Whs.Lhh+h....tlDPtphlpc...t.......................................................................................	0	49	92	149
+11908	PF12075	KN_motif		KN motif	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3795 (release 23.0)	Motif	This small motif is found at the N-terminus of Kank proteins and has been called the KN (for Kank N-terminal) motif. This protein is found in eukaryotes. Proteins in this family are typically between 413 to 1202 amino acids in length. This protein is found associated with Pfam:PF00023. This protein has two conserved sequence motifs: TPYG and LDLDF. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors [1].	19.50	19.50	20.50	19.80	17.80	17.40	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-7.95	0.72	-4.16	15	233	2009-07-11 10:36:48	2009-07-11 11:36:48	3	29	67	0	116	195	0	39.40	60	4.24	CHANGED	PYSVET....PYGYpLDLDFLKYV-DIE+GsTIKRl...slpRRs+	...........PYSVET....PYGacLDLDFLKYV-DIE+G....s....Tl+Rl.......slpRRs+.............	1	15	25	59
+11909	PF12076	Wax2_C		WAX2 C-terminal domain	Assefa S, Coggill P, Bateman A	anon	Pfam-B_3756  (release 23.0)	Domain	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 170 amino acids in length.  This domain is found associated with Pfam:PF04116. This domain has a conserved LEGW sequence motif. This region has similarity to short chain dehydrogenases [1].	27.00	27.00	36.20	36.00	26.70	26.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.95	0.71	-4.51	10	156	2009-07-11 10:43:14	2009-07-11 11:43:14	3	5	27	0	77	166	5	157.20	47	28.21	CHANGED	VlLpGssoKVARAIAhuLC++sl+VsMh..sKE-acpLppcl.sschpcNLVhSpo...aos....KlWLVGDGLoscEQh+ApcGTLFlPFSpFPPpchRKD.CsYpsTPAMtlPKohpNlcSCENWLsRRVMSAa.Rsu..GlVHALEGWscHECG.sph...ul-+l.....WEAAL+HGFpP	....................VhLpGsh..SKl..upAlAhhLCp+tlpVhhh..sp-cappl.ppch.ss-hpphLV.......s.op...aps.........KsWlVGchlsscEQthAPtGThFh.Fs....P.h....p.hR+D..CsYtphsAMtlP.cs.hpslcoCE.hhsRtVhpAh.+su..GllHsLEGWstHEsG.....sl...cl-hlWpAALpHGFpP........................	0	10	46	66
+11910	PF12077	DUF3556		Transmembrane protein of unknown function (DUF3556)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2567 (release 23.0)	Family	This family of transmembrane proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 576 to 592 amino acids in length.	25.00	25.00	238.70	31.50	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	574	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.75	0.70	-6.50	14	188	2009-09-11 14:10:01	2009-07-11 12:04:22	3	2	108	0	38	132	5	566.10	57	98.52	CHANGED	MGFlpPchPsVDhsEWpctsRu-Rl+sMAcHWAEhGFGTPhhlHlhYllK.IhlYlLGuWlls.htTsGlsGhscluuWWsEPIVaQKlVLaThLFEVlGLGCGaGPLssRFaPPhGuILYWLRPGTIRLPPWPc+VPhTpGspRTshDVsLYuulLssllsALhosGs.....GPlsth.....sstlGllssWplssllslLuVLGLRDKlIFLAARGEhYushhlsFhF......G...usDh......IlAsKllhlslWhGAATSKLN+HFPaVlusMhSNNPlh+s+...hlKRpha+caPDDLRPStLuchlAH.huTslEhLVPLlLhFupuGas.TslAAsl.MlsFHLsILSshPMGVPLEWNVFhlFullhLFlua...uslGls-lpsPh.lulLhAslssssllGNLaPc+lSFLPuMRYYAGNWsTolWCh+P.uA--Klcp.sllthuuhstsQLp+h.Yus.EsAplhhahuhAFRuMpoHGRALhoLhhRAl.ustDED-YslpEGEhlCusslGWNFGDGHLHNEQLIAAlQpRCsF-PGElRVllL-uQPIH+QpQpYRlVDAATG.hERGYVpVuDMlscQPWs-...........-...lPVcVt.s	..MGFLpPcLPD.V.DhspW.ptsRpp+lpshupHWAEhGFGTPhhlHLhYlsK.IhL.YlluGhhIl.hhTsGlsGh...oclusWWspPIVaQKVVlaThLFEVlGLGCGaGPLssRFaPPhGuhLYWLRPsTIRLPPWPD+VPaTpGspRTsVDVALYAllLhhllhALhos.Gs.....sPlsth........GstVGLlssh.lVshlllLuVLGLRDKsIFLAARGEhYhshhlsFhF.............s...hsDh......IlAhKllhLslWhGAATSKLN+HFPaVlusMhSNNPLlRsR...hIKRhha+caPsDLRPuhLu+lhAH.suTslEhlVPllLhhu..psGaP.ohlAssh.MVsFHLsILoslPMGVPLEWNVFhIFullhLFlua......uslulsDlcsPl.LAlllAVlAhlVIhGNLhPcKISFLPuMRYYAGNWsTolWCh+P.uAEsKlpp.ulVt.uuhsssQLt+h....Yss.-pApI.h.hs.hAFRAMpoHGRALhoLhhRAh...cDEscYsIp-GEhlCushVGWNFGDGHLHNEQLIAAlQcRCsFpPGElRVllL-uQPI..HpQpQpYRlVDAATG.FEcGYVpVuDMlsRQPWs-...-.lPVHVt..p..............	0	7	22	33
+11911	PF12078	DUF3557		Domain of unknown function (DUF3557)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2154 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 150 amino acids in length.	26.20	26.20	26.30	26.30	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.91	0.71	-4.50	33	542	2009-07-11 13:46:58	2009-07-11 14:46:58	3	7	5	0	539	545	1	145.30	20	38.35	CHANGED	Kl+-Ah+YLlp+Lh..uuRss.lplpp...Lplss....tslL.RlP...psl+l+lppLcl...sspsspllcsl..psllcsoohPLpolplsss........phscsllpouchLhltsthh.............ptLhplpsp+Vclt......hshpphhcL.lcpW.lcpu......+p.lGThaoFshpp	...........................................pshchlhphhh....ss.R...p.t...l.pVpp...lt..h.t.t..................tt.h..h..phP......sh..+h.c.l.p.pLph..............hp..........phhptl..........s.hl..c.s.ohPLcp..l.phtht..................tth.cp....sl.lp...s.AcpL.hlpt.h.................................phltpL.p.Npp..lhlp.......ththsh...p..s..h.htl....lcpW.hpst......+p.lGTpaph....t...............................................	0	42	43	539
+11912	PF12079	DUF3558		Protein of unknown function (DUF3558)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3489 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 177 to 195 amino acids in length.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.49	0.71	-4.61	27	517	2009-07-11 13:51:31	2009-07-11 14:51:31	3	3	154	0	133	423	2	165.90	21	85.88	CHANGED	sssluGCu..s.sGsssstsssss....sss.....phss........hhtt..CssloDspl.schh......Gsssh.h....ssshsus......sCpWptss......h....shs.loh.aacsuslspERphtpththslp-h....sIsG+puh.hupssss.....sssCslsl.stusshls.....W.l.phps....tshs..Ds.C...shApcLspholsps.	.............................................h..hlsGCs....s.s..Gs..s.ss..ussss...................sps.ts.sptp.ss...............................hhc...C.ts.losptl.sc.hh.................Ghssh....h........psshsus...........tCpWpuss......h................ths..loh.....h.hp.....ts.s...l....s...p...p...c....p.....ssctht.hp...s.psh..........sIsGp.......su..h..hhtssps.......susC.tVsh.....tsu.s.....s...h..lp.....hsl....shps......sts....Ds..C...s.Atclhp.sltp..p...............................................................................................................	0	28	94	120
+11913	PF12080	GldM_C		GldM C-terminal domain	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3275 (release 23.0)	Domain	This domain is found in bacteria at the C-terminus of the GldM protein. This domain is typically between 169 to 182 amino acids in length. This domain has two completely conserved residues (Y and N) that may be functionally important. GldM, is named for the member from Cytophaga johnsonae (Flavobacterium johnsoniae), which is required for a type of rapid gliding motility found in certain members of the Bacteriodetes [1].	29.00	29.00	35.80	34.80	28.40	26.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.00	0.71	-4.33	26	164	2009-07-11 14:11:47	2009-07-11 15:11:47	3	3	148	0	57	170	155	176.40	31	35.45	CHANGED	sIuuDKMNVlYRGlsNPhoIulPGlssspVs...uous..G..Lp+tuss.tahhpPs..p.Gpc.lpIsVoup.ss.Gpsls.sppsFRlKslPsPh.........Gslpspt....ssphs+psLpsus.lsAsh.pDFsF-lshpVsuFplplssp.....ssltlsGschsups+shlp+sc+G-tl.ItcIcsphss	........sluADhMNVLYtGh..sNPloIShPGlssspVs...sohs.....GupLsppGsu...palsp....Ps....s.Gpc.lsIsVoup.....Gpshp...uphsFRV+plPcPs.........ushpthp.....ssthsKssLhsss.lsAsl.-Dh.hD.lsapVsuFch.hh..hcp.......sslsssGsphos..pt+stl+php+GcphhIsclpspss.s..................	0	28	51	57
+11914	PF12081	GldM_N		GldM N-terminal domain	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3275 (release 23.0)	Domain	This domain is found in bacteria at the N-terminus of the GldM protein. This domain is typically between 169 to 182 amino acids in length. This domain has two completely conserved residues (Y and N) that may be functionally important. GldM, is named for the member from Cytophaga johnsonae (Flavobacterium johnsoniae), which is required for a type of rapid gliding motility found in certain members of the Bacteriodetes [1].	25.00	25.00	29.70	25.60	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.17	0.71	-4.78	30	171	2009-09-11 04:40:41	2009-07-11 15:15:05	3	4	147	0	54	178	163	186.50	24	38.17	CHANGED	EVLsuFshhN..cpLcposssscppNcpshssL..ssKss-sstchtphhppAppl+ptoschhsalpslKpplhpsss..ctp....hpshc+sstl-..pthhhGst.hsscGp..clhpclspY+stlhthh..stphpp.hh.ttlptphssss......ppps.tppcahphpFps.hPllAulshLTphQs-l+psEu-llspLluut	.........................................................................................-VLsuFshlp..csLppostsssp...pNpthhpsl..ptp..hppsst..+htthhp.cAppl+pho.cslhsalppLKtplscp...u-st..csp...........htslc.pp-sl-.s.......sthhh.us....hsscGp..cLhpplssY+..pplhphl.............t..hpt..hh..phlp.sphsTpss....................ppps.ts+sW.phhFcs.hPssAulThLoplQuDl+tsEu-llpsLlss.h........	0	26	48	54
+11916	PF12083	DUF3560		Domain of unknown function (DUF3560)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2138 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 120 amino acids in length. This domain has a conserved GHHSE sequence motif.	27.20	27.20	27.40	27.40	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.68	0.71	-4.08	24	275	2009-09-10 16:38:42	2009-07-12 10:48:23	3	5	224	0	27	224	3	124.50	54	30.84	CHANGED	sshtpRtpsRspRapshAs+Asscucptaptucphs-slPh.GQPILVGHHSEpRcR+hh-RhcsshtKAlthp-KAc.......aapp+A.tusspsshspcsP-s.lc+l+thhAsh+pspcph+sts+hl+pt	.....os..LsERQEARAERFouYSuKRAuESsQAl-cV-RLAuhIP..GQPILVGHHSERRARRDAQRIENGMKRA.VMLaERAE.......YWEERAc..S.AL.hHAKYKERPDV..RaRRIKKIEADLRKAEKoIApSpKYLsha............	0	6	17	26
+11917	PF12084	DUF3561		Protein of unknown function (DUF3561)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2401 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.	25.00	25.00	27.40	27.20	22.90	21.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.51	0.72	-4.20	10	531	2009-07-12 09:49:57	2009-07-12 10:49:57	3	1	525	0	37	121	1	104.80	72	98.87	CHANGED	MRNopNl.hlopsDs.hppcDEsTaShsGAVVGFlSWLLALuIPFLlYGuNTLFFh.LYTWPFFLALMPVuVlVGIALasLLcG+LlYSlhuTlloVsslFuhLFhWLhG	......................MRNSHNI.TlT.s.NDu.hsEDEETTWS.LPGAVVGFlSWLh..ALAhPh.LlYGS.N.TLF.FF.lYTWPFFLALMPVAVVVGIALHSLhcGKLhYSIlFTLlTVGlMFGALFhWLLG......	0	1	8	21
+11918	PF12085	DUF3562		Protein of unknown function (DUF3562)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3549 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 62 to 84 amino acids in length. This protein has two completely conserved residues (A and Y) that may be functionally important.	26.30	26.30	32.40	32.20	25.00	23.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.04	0.72	-4.15	14	97	2009-07-12 09:51:43	2009-07-12 10:51:43	3	1	71	0	22	65	2	69.50	39	94.74	CHANGED	hs.ssh.............-tlcphApcpuhss-.Vcphhs-phcsLuu-ARVHDYlplFAhR+VRcphR....................spsstt+	................MhQssl.-.lpulApcpshss-tVpchh--plspLusGARV+DYLpVhshRRVREplR........sR.....st...................	0	2	4	13
+11919	PF12086	DUF3563		Protein of unknown function (DUF3563)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3639 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 50 amino acids in length. This protein has conserved AYL and DLE sequence motifs.	26.90	26.90	26.90	27.20	26.50	24.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.92	0.72	-4.22	5	136	2009-07-12 09:54:44	2009-07-12 10:54:44	3	1	79	0	42	82	23	51.90	45	93.77	CHANGED	MYL...lS+LFLFLTKshDpusKEcp...DAYLAEATDLYDLEFRMRKID.R-Ash+pPSshss+	.....................huhlh..hLop.hE..p..s.....t+ERp...-AYLAsuoDlhDLEhRhRpL-...pshu..........h................	0	1	10	22
+11920	PF12087	DUF3564		Protein of unknown function (DUF3564)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3736 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 118 to 142 amino acids in length. This protein has a conserved WSRE sequence motif.	25.00	25.00	44.20	99.20	21.90	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.71	0.71	-4.53	7	93	2009-07-12 09:56:13	2009-07-12 10:56:13	3	1	57	0	26	75	2	119.20	52	95.53	CHANGED	MRlTl+lsT.-sss.tuaAlLWLDpsp+tWSREuHtGl-LPpWGsltsspGsstl...suADsspslCpLpGLclsshpGshEu.EpGpAhWh..ut+sPhhGtW+lQsVDpssspPEat.Fsttp	MRLTI+ls.u.-uss...puaAVLWlDTDEphWSREuHpGIDLPsWGcV+sspGsstL...CuADsscuLCpLcGLshust..............pt...Es.EpGsAhh......us+sP..sGAWRLQsVDpssspsEHc.FTsht..	0	2	5	17
+11921	PF12088	DUF3565		Protein of unknown function (DUF3565)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3033 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 30 to 78 amino acids in length. This protein has two conserved sequence motifs: WVA and CGH.	25.00	25.00	29.40	29.30	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.18	0.72	-4.20	19	114	2009-07-12 09:58:00	2009-07-12 10:58:00	3	4	112	0	40	105	12	56.00	50	70.94	CHANGED	lGaHpD-EsHWVApLuCGHsQHVRHpPPWpsRsWVlT.pGRpshLGt.LsCtKC-puustD	..hsacpD-EsHWVA.LuCGHsQHlRHpPPWpsRsWVlottGRpphlGphlsCt+Csputs........	0	10	19	32
+11922	PF12089	DUF3566		Transmembrane domain of unknown function (DUF3566)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3331 (release 23.0)	Domain	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 136 to 304 amino acids in length. This region represents a transmembrane region found at the C-terminus of the proteins.	45.90	45.90	52.10	51.60	38.50	38.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.53	0.71	-4.09	24	434	2009-07-12 10:02:00	2009-07-12 11:02:00	3	1	432	0	113	310	175	118.90	40	54.26	CHANGED	ssRRscLplsRlDPWSshKloFllSlulhllhlVAsslLahlLsuhGVFsplsshlsslsssssu......sltshlohGpVhuhusllullsVVLhTALuTluAhlYNlsusLlGGlcVTLu-c	......psR+ApLplsRlDPWSshKlShlLSlAhhllhhlAsslLahlLsuhGVasplNpslsslhsssuu......phsp..hlohGpVluhssLlGslNsVLhTALuTluAFlYNlsusL..lG.GlEVTLu-c..	0	34	83	105
+11923	PF12090	Spt20		Spt20 family	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3386 (release 23.0)	Family	This presumed domain is found in the Spt20 proteins from both human and yeast.  The Spt20 protein is part of the SAGA complex which is a large cmplex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.	32.00	32.00	34.90	35.10	30.30	28.50	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.21	0.71	-4.93	32	305	2009-07-12 10:47:42	2009-07-12 11:47:42	3	4	214	0	208	305	0	201.60	29	23.78	CHANGED	ssppl.L++at.................................................p.......sSlhl+lasspa+a..................................................................s.ppshhhsYss.h.+thLcalcptplP.pthh-lL..........................pp..s...............slpFY-GCl.IlplhDa+s...................................................................t..............tt...........t..t.tp.tt...............pPcsapslL+PTstolhhDlhhhsss...................................................tphssp.hhphEucllt.sTsts................LsL-ss.s.......stpttshLp.p	.......................................................................h...tl.LcKh............................................................ssLllpLaPsphtas.....................................................................................s.scshphPYcp...pplL-alcscplP.s.Ll-lL................cc..s......................sl..Fas............GCl.Iscl+DaRp.......................................................................................................................................................................................st.psp+llL+PT....poLhsDlp.h.sss..............................................................................ttpaopc-...tLtlESpllh.ATstP................LsL-Pshs.........stpstshh...hh...................................................	0	58	93	145
+11924	PF12091	DUF3567		Protein of unknown function (DUF3567)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3056 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 90 amino acids in length. This protein has a conserved EIVDK sequence motif.	40.90	40.90	50.00	47.60	32.30	30.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.88	0.72	-4.01	11	117	2009-07-12 10:52:43	2009-07-12 11:52:43	3	1	116	0	45	74	12	87.40	57	98.69	CHANGED	MQMlYsS-sasVVch.........sPDssh................ttLsptGaEIVDKpup+ElaLDGuhAEhFppclpshhpspPo.EEVDDhLspYsuLhppPVllH	..MQMIYNSsNYCVVEF................sPpss+..............tshsuGGYEIVDKNupREIFlDGplAE+FRccVcpLIps.EPol-EVD-FLGpFDoLMpQPVVlH.	0	2	20	33
+11925	PF12092	DUF3568		Protein of unknown function (DUF3568)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3573 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 130 amino acids in length.	37.00	37.00	39.00	38.70	32.50	32.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.51	0.71	-4.43	8	164	2009-07-12 10:55:55	2009-07-12 11:55:55	3	1	45	0	26	90	3	129.80	34	95.07	CHANGED	+KlhllhLhsh.slsLsuC.hlsAllsGsus.tuGsstY..lsGpYhs-l.stsacsVYsATlpAIpsspsaslpspshs.....p..psAsIsus........sKsss-slplclpKlscNsTclpIKhGshGDpttSusLhspIpcNl	.............Khhlhhlhsh.s..lsLsSC...ssullsGhu..sssuu.......s.stY..lsG...pYhhpl.stshpsVYsATLpAlpssssaslp.spshs.......s..pcApIsus........scssssshplplp+lssssT+lpIKaGshG..DpttSusLhspIppsl..........	0	15	19	19
+11926	PF12093	Corona_NS8		Coronavirus NS8 protein	Assefa S, Coggill P, Bateman A	anon	Pfam-B_2038 (Release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in coronaviruses. Proteins in this family are typically between 39 to 121 amino acids in length. This protein has two conserved sequence motifs: EDPCP and INCQ.	27.00	27.00	52.50	52.50	18.40	17.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.79	0.71	-3.74	2	88	2009-07-12 11:00:27	2009-07-12 12:00:27	3	1	70	0	0	20	0	68.90	56	96.56	CHANGED	MKLLIVhshlo.s.CI..csslQcCspNpPa.lEDPCPhtY.s-W.I+htoR....poAhLstL.....GKhlPhH..hatshs.oCpP.lpINCQsPssGuLIsRC.Y.a-...hsta+DVhVVL	....MKLLIVhshlo.s.CI..psslQcCspNpPa.lEDPC.lp.......................................................................................	0	0	0	0
+11927	PF12094	DUF3570		Protein of unknown function (DUF3570)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3745 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 396 to 444 amino acids in length.	25.00	25.00	170.60	170.20	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	420	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.54	0.70	-5.74	41	141	2009-07-12 11:02:17	2009-07-12 12:02:17	3	1	118	0	71	143	85	412.60	24	92.13	CHANGED	tlstsLshs..........ssullussstsps.....................................cl-...hthhhYpE............ps.psssstshsshc...............pshu-cp.slshchslDsloGASssssss..................h.tspt...sssapstuGtssh.t...................DTRhphssshsp..hspshphshusphSpEhDYhShuhsh.ulspshspcNTolohuhuht.Dpl....thshthpt.....t....................................s-s+pshshhlGloQlls+phlhphshshstssGYLosPY.+hlphhDss..............s.s.............................................t.hh.hEpRP-sRh+tul...hhpspatls..sssh....chpYRYasD-WuIsSHTh-scahhtlssph..h........lpPphRYYpQssAcFYp......shh.psp.s..h............s..........pahouDhRLushsuhohGlp...........hs...........hphtsthplshphthYppssshs.........G.....................................................thpshhlplshpF	......................................t......hhhshshhsts.t..sts.th.tct......................cls...hthhhYp-....................ps.psssssshsshp......................pshucct.slshchslDslouASssssss...................................t....ssths...h.uG.ts.......................................................DsRhphshshsh..hppstphshGsshSpEhDYpShGhsh.uhspshspcNTololGhuhhhDpl.psh..hssshps...................h........t......................scs+pohshtlGloQllspphhhphshshstpsGa........LosPY.+hlp..hhDss..................s..........................................................t.hh.hEphPDsRh+hul...hhpsphhls....sssl..chpYRYapDDWGlsoHTh-hchhhhlss.pa..t..........lpPphRYYsQ.ou.AcFYp.........shh.ts...s.....h...........................................................s............pahouDacLusasuhshGlt.................hs........hphttthphshphtaYppssshs........................................................................h.h...........................................................	0	28	54	65
+11928	PF12095	DUF3571		Protein of unknown function (DUF3571)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3506 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 85 to 97 amino acids in length.	25.00	25.00	25.10	59.60	21.60	17.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.79	0.72	-3.75	23	90	2009-07-12 11:05:05	2009-07-12 12:05:05	3	2	87	1	41	92	116	83.50	41	82.07	CHANGED	MuDP...LlRspDpYVVLE.PspsEphLTssEhLtaLpphLpp..h-sL.PtDLpchsolsstAp+Ll-TAC-LEl.uPGhslQWaAVRLE	......Msss...lhh.ppDpaVlLE.PspsEpFLospELht+LcshLpp..tssL.P.DLpchsolsstApaLl-osCEL-l.GsGt.hlQWYsVRLE.	0	7	27	37
+11929	PF12096	DUF3572		Protein of unknown function (DUF3572)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2130 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 100 amino acids in length.	35.20	35.20	46.70	61.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.82	0.72	-4.14	41	202	2009-09-11 14:10:56	2009-07-12 12:08:04	3	1	199	0	63	161	66	88.30	42	89.90	CHANGED	hst-sAEslAlpALuWlAus--LLshFLutTGhusssLRpsAsDPsFLuuVLDFlhhDDAhVhAFs-utGls.ppshtARtsLPGu....st.	.........sptsApslAlpALuWLAsD.c-lLsRFLAhTGlpssslRpuAp-PuFLuuVLsFlhscEssLltFC-psGhcPsthtpAhthLsGu..s.....	0	14	37	46
+11930	PF12097	DUF3573		Protein of unknown function (DUF3573)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2286 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 372 to 530 amino acids in length.	26.60	26.60	26.60	27.30	26.40	24.90	hmmbuild  -o /dev/null HMM SEED	383	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-12.37	0.70	-5.85	5	128	2009-07-12 11:17:35	2009-07-12 12:17:35	3	1	33	0	12	96	0	354.20	51	73.37	CHANGED	hFpKphLIloslLshuhhsahspS.thhs...........................s.QsssSpplD+psIocLQpQIppLQuQINpL-pp.......psoNtsupFsTYSSKVsss....olsulGpoKsLussphNNphsoDIhsNlss-ssIIsLuupslGGlFspcGuIDVGNAPAITTQGQlTYLGSYSGNNTIPIGQISSNLFASTIlGQR-KFDsYSIFFGGaIEADAQsWFGSuIo+u....ssuosFsSNGQNIYLToAsLYFLANlGHYVTAsaDFsTsEsNNFuLGNAFVIFGNLDTSPaFVTVGKs.RlSVGoFGGGGPWTSGITtNFLsPGRVTNluLNYKoDThNANVTVFuopNpHAsFSsAlFYAsKhTsNIA.VGFNhGYlaDlAGAsNsSls+hh.phsahsKoVGpFN	.....................................h.Kh.llh.hhL....h.aht.S.th.s.................................Qsstup..-pptl.pLppQIppLQupIspLcpp............p.s....p.pFsTYSSKVssp.....hh..t.Gpspsl.sp.s..ss..tsclhsN.s.pps.lsLusp...tlFspsGuIDVGsAPAITTQGploYLGSYSGNNolPIGpIsSNLFASTlltQRsKFDsYSlFFGGaIcADAQhWFGosIs.s....psu.sshsuNGQNIYLToAsLY..FLuNlGHYVTAphDFsTs..-sNsFsLtsAFVIFGNLDTSPaFVTsG+s.+lSVGoaGG...GGPWTuGITtsFL.sPs+VTNl.SlNYKssshNANl.sVFuop....sp+AsFSsulFYAsp........hTsslA.lGFNhGYlaslAGAsNs.Slsp.h.phsh.scslGshN.............................................	0	7	7	7
+11931	PF12098	DUF3574		Protein of unknown function (DUF3574)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_3542 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 144 to 163 amino acids in length. This protein has a conserved TPRF sequence motif.	25.00	25.00	25.00	27.10	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.34	0.72	-4.44	21	194	2009-07-12 11:23:53	2009-07-12 12:23:53	3	1	194	0	67	196	59	103.70	42	69.59	CHANGED	lps-LhFGhshssss.......sVS-A-appFlcc-VTPRFPDGLTVhDApGQW+s.ssGp..lsREsoKllhllasssssp.csslpsIRpuYKp+FpQpSVhhsspPsCVSF	.....................popLaFGhsps.sGs.......sIoss...-WppFlDcpVT..PRFsDGLTVaDAcGQWhs.ssGp..lsREpSKslhllas..s.s..s.ss..cssl-AlRpsYKpcFtQpSVhhlppsVCVuF................	0	14	27	46
+11932	PF12099	DUF3575		Protein of unknown function (DUF3575)	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2229 (release 23.0)	Family	This family of proteins are functionally uncharacterised. This family is only found in bacteria.  Proteins in this family are typically between 187 to 236 amino acids in length.	27.90	27.90	28.50	28.80	27.40	26.20	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.18	0.71	-5.21	39	605	2012-10-03 17:14:37	2009-07-12 12:36:53	3	4	114	0	65	504	70	197.20	28	78.01	CHANGED	h+phhhlh................................................hhllhhsshh............................................tuQplAlKoNlLYDA.sss.NlGsEhslu++WolslsspYNsWp..a.ucs........+ph+tahspPEhRYWh.......scpa.sGHFlGlauphGpYNh..ush...hs............phpcpR.YpG..hhaGu.GloYGYpahLuc+WslEhslGlGYsphcYcKYsssc.Cush.hspscp.sahGPTKAulSLlY.ll	......................................................................................hhhh..........................................hpspphAlKoNlLa.u.s.t.........s.........sNlGlEhs.l....u....c....+....h...olsls..s..sas.s...Wp....h....s.c...s.........+..p..h+hahl.pPEhRYWh............................................scph..sG..aFlGlau...tsup.aNh.......................ph.p.cp+Y.p.G.......h..h...Gu..GloYG.....YphhL.....u..c....+..Ws.....lEhslG...lG....YhphcY.......c.+....Y.tsh.......s......sst...h......htpt.pp...s...a....h....G....P....TKsulSllYhh..........................................	0	21	53	65
+11933	PF12100	DUF3576		Domain of unknown function (DUF3576)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2102 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 100 amino acids in length. This domain has a single completely conserved residue G that may be functionally important.	25.00	25.00	25.60	42.20	24.50	16.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.37	0.72	-3.98	34	167	2009-07-13 12:12:39	2009-07-13 13:12:39	3	1	167	0	52	147	1293	101.70	45	60.38	CHANGED	ssluV.NpYLWpASL-sLsFhPltosDPFuGVIlTs.YusPsusscpa+.sTVaIhDssLcAcuLpVul..QspsG......tsVsssTspslEsAILoRA....RQLRlp	....s.huVNpYLWpAoL-TLSFhPlsSsDs.GGVIlT-WYusPsssscRaK.lslaIhDssLcuDulcVslhcphpps.ttWh.ssssusTspslEDtILoRA....RpLRl.s............	0	21	39	42
+11934	PF12101	DUF3577		Protein of unknown function (DUF3577)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2116 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 143 to 307 amino acids in length.	25.00	25.00	27.00	26.40	24.10	17.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.51	0.71	-4.28	18	264	2009-09-11 09:40:19	2009-07-13 13:15:57	3	2	181	0	85	234	9	132.20	44	83.97	CHANGED	ssssspspYFNLHssGlGYLNcIRcVp.........s++GpsFhACsIAALpGsoDsspYsaFDssVsGpEApcLIcRCpcAVcs-+KVLluFpluDLasDsFTasp.....Gc+pG..-suVSLKuRLlhlsWIKVDGchlYpApspssssss	.........p..tsspppYFsLpTsGIGYLsRlR-Vs.....s+cGpsFLuCsIAALs.Gss...Ds...sp.....YphFDspVuGsEApcLlpR.C.pA........l.....-.t.....c+KV.LluFRL.uDlhsDsFhhsK.....G-+tG..-....susSLKuRLl+lshIKlsGphVYpstttptt..s...........	0	8	42	68
+11935	PF12102	DUF3578		Domain of unknown function (DUF3578)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2328 (release 23.0)	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 177 to 191 amino acids in length.	25.00	25.00	26.40	26.40	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.06	0.71	-4.69	18	298	2009-07-13 12:20:20	2009-07-13 13:20:20	3	10	279	6	54	186	75	180.50	34	35.53	CHANGED	pclhspYhpt+spp.Fppp......thsphlcpcl.cplpppshlspptah.VcGSsGQGsWAclPWlulhscplTsospcGhYlVYLFssDhsslYLoLsQGhTchppph....tspsplcphsphh+shlpp..ppt..hsspIpLtsph.........hspsYEpusIthKtYshs.sl..PsccpLhpDLcpllshYpphhsph	...........................................plhp.hhpt+Tpp.http...........htpll+p.cls...cp..lps......alccc..cY...Vs.GplupG.N.aupVPWIulhDcsITp.......pTpcGaYlVYL.Fp..s-h-sl.YLoLsQGhochsc.a.........psKsthc.phu..plpspl.sp.....spp.hsssphhhupspt........hspGYspusIta+hYDls..ch.............s-..-chlpDLcchLchapplhs..s...............................................	0	17	37	44
+11936	PF12103	Lipl32		Surface lipoprotein of Spirochaetales order	Mistry J, Gavin OL	anon	pdb_2zz8	Domain	Lipl32 is an outer membrane surface lipoprotein of Leptospira like bacteria.	25.00	25.00	88.20	87.90	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.28	0.71	-4.82	4	121	2009-07-13 14:59:56	2009-07-13 15:59:56	3	1	47	9	6	90	0	179.70	90	77.15	CHANGED	shcltlPYssslsYaGYlcsuspPDuhlcG.KcAYYLYlWVPAVlsElGVRMISPsu..upPscuDhVpcuFpsshpu-.p..+aFDTaIplERhsllps-cIs.KuAKsh.hptLsssDDus-h.cp.ptupYNSLhRhcSplusPsKA............LVRGLYRIuFTTYKoGcVcGSFlAoVG....sslPGVsh	.TVKThLPYGSVINYYGYVKPGQAPDGLVDGNKKAYYLYVWIPAVIAEMGVRMISPTGEIGEPGDGDLVSDAFKAATPEEKSMPHWFDTWIRVER.MSAIMPDQIA.KAAKAKPVQKLDDD.DDGDDTYKEERHNKYNSLTRIK..IPNPPKSFDDLKNIDTKKLLVRGLYRISFTTYKPGEVKGSFVASVGLLFPPGIPGVS.P...	0	1	3	5
+11937	PF12104	Tcell_CD4_Cterm		T cell CD4 receptor C terminal region	Mistry J, Gavin OL	anon	pdb_1q68	Domain	This domain is the C terminal domain of the CD4 T cell receptor. The C terminal domain is the cytoplasmic domain which relays the signal for T cell activation. This process involves co-receptor internalisation. This domain is involved in binding to the N terminal of Lck co-receptor in a Zn2+ clasp structure.	20.60	20.60	20.60	20.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.87	0.72	-7.13	0.72	-4.36	5	89	2009-07-13 15:23:31	2009-07-13 16:23:31	3	15	45	9	23	90	0	27.50	74	6.42	CHANGED	RRRAcRMSQIKRLLSEKKTCQCsHRhQK	.........RRpAcRMSQIKRLLSEKKTCQCP..HRhQK....	0	1	1	5
+11938	PF12105	SpoU_methylas_C		SpoU, rRNA methylase, C-terminal	Assefa S	anon	PFAM-B_2024 (release 23.0)	Family	This domain is found in bacteria. This domain is about 60 amino acids in length. This domain is found in association with Pfam:PF00588. This domain has a conserved LFE sequence motif. Some members of the Pfam family SpoU_methylase, Pfam:PF00588, carry this very distinctive sequence region at their extreme C-terminus. The exact function of this region is not known.	25.00	25.00	25.60	26.50	24.20	21.30	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.72	0.72	-4.41	53	711	2009-07-13 15:25:21	2009-07-13 16:25:21	3	2	708	1	104	324	122	58.50	70	25.78	CHANGED	RQRpsAGhYspp..tLss-php+lLFEhuaPhlAchC+c+GhPYPtLc.-pGpIlsctsa	.....RQRQNAGMYLRENSMLPEsEQQRLLFEGGYPVLAKVAKRKGLPYP+VN.QQGEI-ADA-W............	0	14	41	76
+11939	PF12106	Colicin_C		Colicin C terminal ribonuclease domain	Mistry J, Gavin OL	anon	pdb_2dfx	Domain	Colicin is a protein produced by bacteria with Col plasmids. Its function is to attack E. coli through actions on its inner membrane ion channels or through ribonuclease or deoxyribonuclease actions. The C terminal domain is the ribonuclease domain. It specifically cleaves tRNA anticodons which recognise codons in the form NAY (N:any nucleotide, A:adenosine, Y:pyrimidine) which corresponds to Tyrosine, Histidine, Asparagine and Aspartic Acid. E5-CRD can be referred to as an RNA restriction enzyme that specifically recognizes and cleaves single-stranded GU sequences. [1]	25.00	25.00	37.10	29.80	22.10	15.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.21	0.72	-4.37	12	86	2009-07-13 15:32:11	2009-07-13 16:32:11	3	14	21	10	69	94	0	34.60	49	16.18	CHANGED	GsVssshscpssscT.PDulsppsSusVhs.psssY	.GsVlhVls-ss-scThPDSVoo.PSuoVVV.pVVVY...	0	3	69	69
+11940	PF12107	VEK-30		Plasminogen (Pg) ligand in fibrinolytic pathway	Mistry J, Gavin OL	anon	pdb_2doh	Domain	Pg is an important mediator of angiostatin production in the fibrinolytic pathway. Pg is made up of five subunit kringle molecules (Pg-K1 to Pg-K5), of which the first three make the protein angiostatin. VEK-30 is a domain of the group A streptococcal protein PAM. It binds to Pg-K2 of angiostatin and activates the molecule to mediate its anti-angiogenic effects. VEK-30 binds to angiostatin via a C terminal lysine with argininyl and glutamyl side chain residues known as a 'through space isostere'. [1]	20.80	20.80	20.90	21.10	19.20	20.60	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-5.87	0.73	-6.24	0.73	-4.10	8	126	2009-07-13 15:37:18	2009-07-13 16:37:18	3	14	3	12	0	125	0	16.50	71	9.92	CHANGED	DDsELcRLKNERH-HDc	..-sELERLKNERH-HDc	0	0	0	0
+11941	PF12108	SF3a60_bindingd		Splicing factor SF3a60 binding domain	Mistry J	anon	pdb_2dt7	Domain	This domain is found in eukaryotes. This domain is about 30 amino acids in length. This domain has a single completely conserved residue Y that may be functionally important. SF3a60 makes up the SF3a complex with SF3a66 and SF3a120. This domain is the binding site of SF3a60 for SF3a120. The SF3a complex is part of the spliceosome, a protein complex involved in splicing mRNA after transcription.	19.10	19.10	19.40	19.10	19.00	18.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.79	0.72	-7.02	0.72	-4.40	20	244	2009-07-13 15:39:18	2009-07-13 16:39:18	3	8	212	1	178	228	0	27.60	47	5.54	CHANGED	sulu..ss-.asEFYcRLcpIK-aH++aPN	..........slo..uss.FsEFYsRLKpIK-FHR+aPN....	0	61	94	144
+11942	PF12109	CXCR4_N		CXCR4 Chemokine receptor N terminal	Mistry J, Gavin OL	anon	pdb_2k03	Domain	CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1. [1]	20.30	20.30	20.50	26.60	18.90	19.70	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.39	0.72	-4.15	4	102	2009-07-13 15:43:43	2009-07-13 16:43:43	3	2	77	15	21	91	0	32.40	82	9.34	CHANGED	I.huDNhSEE.lGSGDY-shpEPCFpcENucFNR	.....IYTSDNYTEE....hGSGDYDShKEPCFREENAHFNR.	0	1	2	6
+11943	PF12110	Nup96		Nuclear protein 96	Mistry J, Gavin OL	anon	pdb_3bg0	Domain	Nup96 (often known by the name of its yeast homolog Nup145C) is part of the Nup84 heptameric complex in the nuclear pore complex. Nup96 complexes with Sec13 in the middle of the heptamer. The function of the heptamer is to coat the curvature of the nuclear pore complex between the inner and outer nuclear membranes. Nup96 is predicted to be an alpha helical solenoid. The interaction between Nup96 and Sec13 is the point of curvature in the heptameric complex. [1] [2]	25.00	25.00	29.20	28.40	23.50	22.20	hmmbuild  -o /dev/null HMM SEED	290	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.65	0.70	-5.30	36	380	2009-07-13 15:55:46	2009-07-13 16:55:46	3	13	307	11	219	392	9	259.90	30	20.01	CHANGED	s.hEphhhhLsupclpcAschAlpupsh+LAsLlo.l.usssss+p.hppQLppW+ppss..s.lspshhclYcLLuGsshhspss.t....................tlsWhpshGL+LaYupssp....slccslppatcslsp............s.....................pt..hpshhatLL+lY......sspst..........shpth...lts.shssssLch+LsWhlhplLpshshhpt.t..........................................t........DpLshsaAspL...cspGhap.AlFVlhHlssssp....Rcpsl+plLtRphptlss.t..............sp.palhpcLplPpsWIapApAlhs+sps	........................-thh.hLsspclpcAsphuhpstsh+LAhlluph..s.........s..s.......t.h+p.hptQL.tWpptph...p.............lpp..hhpla...tLLuGpsh.hptuptt.....................h.tlsWhpslul.pLWYhhssss...............olscAlptapcshps.......................t.st.PhP...Yhpt................................sstpsh.DlhapLL..pLa.................upppt................................slpph......LpP...h...sh...o................sssh..D..aRLuWh..LhpsLpulshpphs..............................................tt...s.lphsaAtpL................ps..uhap.A..lFVlh..H.lp.pttt..............................RppslpphLt+p.s.t.hhtp........................................t.phl..hppLtlPtpWlhtAtAlhtt......................................	0	79	126	184
+11944	PF12111	PNPase_C		Polyribonucleotide phosphorylase C terminal	Mistry J, Gavin OL	anon	pdb_3gcm	Domain	PNPase regulates the expression of small non-coding RNAs that control expression of outer-membrane proteins. The enzyme also affects complex processes, such as the tissue-invasive virulence of Salmonella enterica and the regulation of a virulence-factor secretion system in Yersinia. In Escherichia coli, PNPase is involved in the quality control of ribosomal RNA precursors and is required for growth following cold shock. This family contains the C terminal protomer domain of the PNPase core.  The function of the C terminal protomer is to catalyse phosphorolysis through its two active sites. [1]	25.00	25.00	27.20	27.20	24.70	23.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-7.79	0.72	-4.76	16	611	2009-07-13 16:01:04	2009-07-13 17:01:04	3	3	604	16	52	368	0	38.90	67	3.77	CHANGED	Essphu-WQcspahFcGKGuAGtHSAsspspussT+sps	...EuP+HSDWQ.RPoFsFEGKGAAGGHoAT+HASAsPsRPQP..	0	2	13	34
+11945	PF12112	DUF3579		Protein of unknown function (DUF3579)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2027 (release 23.0)	Family	This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 98 to 126 amino acids in length. This protein has a conserved FRP sequence motif.	25.00	25.00	28.40	28.10	19.70	19.10	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.98	0.72	-4.08	19	284	2009-07-13 16:43:08	2009-07-13 17:43:08	3	4	249	1	88	221	35	93.20	46	62.29	CHANGED	hpsp....scchhIpGlTppGKsFRPSDWAERLsGlhupF....psst........+hsYSPastPss.hsGlKCVhVctcL+-hEPhAacFlhNFA+DNcLplh-.tshh	...........h...pspchhIpGlTp.sGKpFRPSDWAERLsG..l..husF....psss...........+lpYS.aV.+Psl..lssl+CVhVDp+LcshpP.AFcFlhsFApDNsLpVh-s..h............	0	18	51	68
+11946	PF12113	SVM_signal		SVM protein signal sequence	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2829 (release 23.0)	Motif	This region is presumed to be a signal peptide sequence found in Sequence-variable mosaic (SVM) proteins [1]. This domain is found in phytoplasmas. This presumed signal sequence is about 30 amino acids in length.	31.70	31.70	34.10	34.10	28.70	27.50	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.46	0.72	-4.12	32	70	2009-07-13 16:58:34	2009-07-13 17:58:34	3	1	15	0	53	69	0	32.70	50	22.02	CHANGED	MFKLKsphhll..pIhLFlhLGLhhIsNN.ppVMAM	..MFKLKNphpll..sIhLFhhLGLhhIsNN.ppVMAM....	0	16	17	31
+11947	PF12114	Period_C		Period protein 2/3C-terminal region	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2037 (release 23.0)	Family	This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with Pfam:PF08447.	25.00	25.00	49.90	27.10	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.43	0.71	-4.70	24	250	2009-07-14 11:56:36	2009-07-14 12:56:36	3	7	74	0	85	198	0	189.60	38	17.03	CHANGED	ssDuhSsSS-LhshlLpEDutS............usuSusSsS..s............tpsS................sussoSpoSpYFGShD.SSEsscps+pstssp.....................ptphh+hVhpDPlWlhhssss-plMMTYQlPsRsh-pVL+ED+EKL+php+.QPpFoc-QKcELucVHsWlpptslPptlslpsClsCpspsss..............shctchpphphsch	...................................................................................ppDu.SsSS-LLplL.......Lp..E..DupS....................uT.GSusSuShssstst....................................uoG.Sts.sssost.............................ssuSpSSpoSKYFGShD..SSEssppsppststp....................tcphl+h.VLQDPlWLlhAss-ccVMMTYQlP.s.RshpsVL+ED+E+L+shQ+pQP+Fo--Q+cELupVHsWl...ppssLPptlslp.sClsCpspsps.............................s.....................................	0	10	19	41
+11948	PF12115	Salp15		Salivary protein of 15kDa inhibits CD4+ T cell activation	Assefa S	anon	PFAM-B_2039 (release 23.0)	Family	This is a family of 15kDa salivary proteins from Acari Arachnids that is induced on feeding and assists the parasite to remain attached to its arthropod host. By repressing calcium fluxes triggered by TCR engagement, Salp15 inhibits CD4+ T cell activation. Salp15 shows weak similarity to Inhibin A, a member of the TGF-beta superfamily that inhibits the production of cytokines and the proliferation of T cells.	27.80	27.80	28.00	30.10	27.60	26.70	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.39	0.71	-3.87	44	93	2009-07-14 12:43:31	2009-07-14 13:43:31	3	1	6	0	7	99	0	128.00	23	94.54	CHANGED	lphhh..........lhlhhslsh..................................sptpspsss.........................slttphsphhsssc...phtpplhphCpp.......................ptlssphls..apsCoahCt.........ssttsphphp....Ls-GhPCG....pspsC.ppGpCss..........h.sC	......................................lhhhhshsh........................................s...ttpp................................s.shphPshhsshp....shhspltptCspt...................p.htsIsshphc...hpsCphtCp.......tpspp.ssplohs.............Ls-GpPCu....sppsC..pscCstp.......ssC..............	0	7	7	7
+11949	PF12116	SpoIIID		Stage III sporulation protein D	Assefa S	anon	PFAM-B_2045 (release 23.0)	Family	This stage III sporulation protein is a small DNA-binding family that is essential for gene expression of the mother-cell compartment during sporulation. The domain is found in bacteria and viruses, and is about 40 amino acids in length. It has a conserved RGG sequence motif.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.64	0.72	-4.05	19	411	2012-10-04 14:01:12	2009-07-14 14:22:57	3	3	388	1	93	317	10	77.20	61	88.65	CHANGED	+-Y....IE-Rsl-lupYIlEs+ATVRpsAKsFGVSKSTVHKDlTERL.pINPpLApcV+plL-hNKAERHIRGGpAT+pKYpctc	..............+-Y..IcERslclupYI.l-s.+..tT.VRthAKtFGVSKSTVHKDlT..E..RLPcINPcLApEVKcILDh.....p.....Ku.RHlRGGcATK.KY+c..p................................	2	48	76	82
+11950	PF12117	DUF3580	DUF_B2046;	Protein of unknown function (DUF3580)	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2046 (release 23.0)	Family	This domain is found in viruses, and is about 120 amino acids in length. It is found in association with Pfam:PF01057.	25.00	25.00	56.30	56.20	22.50	17.60	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.97	0.71	-4.16	6	117	2009-07-14 14:37:12	2009-07-14 15:37:12	3	3	31	0	0	122	0	114.40	62	17.73	CHANGED	t+WGKVPDWSENWAEPKlpTPINSlGSh+Ssppos+STPLSQNYALTPLsSDL.tDLALEPWSTPsTPVAsTlpspNTspuGspu.QsuQtSPTWSEIEsDLRACFopEpLcoDFp-..sLD	........HHWGpVP-WsEpWtEPKlQTPINoPss.pslpTos+ooPtspNYshTPlppDL.lsLALEPWSpPsTPshpssptpsst.sssh+....psSPTWSEIEsDlRAhFsppplpps........s..	0	0	0	0
+11951	PF12118	SprA-related		SprA-related family	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2057 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are typically between 234 to 465 amino acids in length. There is a conserved GEV sequence motif.Most members are annotated as being SprA-related.	27.30	27.30	27.40	27.40	26.80	27.20	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.48	0.70	-11.99	0.70	-5.09	40	267	2009-07-14 15:26:22	2009-07-14 16:26:22	3	4	261	0	76	193	40	227.00	38	76.53	CHANGED	sl.ssuhsshsstssss.sttshtt.t.......................................................................sststsssssspsss..........................................................................s...........ssssstpscp.......................spppsppppttss...........................pp.s..tppphp.p..plpcLppRDpEVRsHEQAHsulGGpaA.GuPoasYppGPDG++YAluGEVsIDlS.lsGDPpATIpKMppVpAAAhAPA-PSutDhpVAApAtpphspA+uELsppcpppssptppspt...........ttpsp.pshp..pppp.phsspsptst................t.lp	............................................................................................................................................................shshhsspsthsp......................................................................................................................................................................................................................................................................................................pppsppppp.p.s.pp.ppspppps.pps.....................p.hs..t.tscL.s.p.pphpQVcELpuhD+pV+AHEtAHtAAG.Gsh.A.GusSFoYp+GPDsphYAsuGEVsIchpp.ussP..EtTIspucQltAAAhAPADPSsQDh+VAAs.AtphphEARAE.ht..c...+s..pcsp..cppppsp.........ttppp.p.ps.t.hpp.p..............s.p.......................................	0	31	54	66
+11952	PF12119	DUF3581		Protein of unknown function (DUF3581)	Assefa S	anon	PFAM-B_2081 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are about 240 amino acids in length.	25.00	25.00	47.40	47.10	20.70	18.60	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.34	0.70	-5.12	22	187	2009-07-14 15:30:18	2009-07-14 16:30:18	3	1	183	0	36	129	22	211.70	61	90.92	CHANGED	MFLssYaspps..splslospQAScFAKplAsDFNPIHDsDAKRFCVPGDLLFAllLscaGLSppMpFcFsGMVucsltLpF.spssssphslsDppsKsYLcVpRuG-sopspshIEshl+sYVsFSGhNFPHlLlPLMcp+pVMINPsRPLVIYESMSh-Ls...pLDhs.pssLcLsssslcl-GKRGsVsLpFpLhsssclVGoGhKcLllSGLRsY-pcs	...MFLosYaSpps.....p.....phpFTRpQAS+FAKtVAGDFNPIHDcDuKRFCVPGDLLFAllLpK.GlSQKM+FcFoGMVuDGVsLplps.c.spcE.uVsDssGKpYL+hSRcG-Vs+ssAhIEpllpsYVpFSGhNFPHIMVPLME-pQhMINspRPLVIYESMpl-Fo...R...LDls..cP-V-FsGAoh-V-GKRGhVTLsFsh+-sGplVGcGlKRMVsSGL+PYDQt.t...............	0	6	15	27
+11953	PF12120	Arr-ms	DNApol_Rpb2_rif; RNApol_Rpb2_rif;	Rifampin ADP-ribosyl transferase	Mistry J, Gavin OL	anon	pdb_2hw2	Domain	This protein is found in bacteria. Proteins in this family are typically between 136 to 150 amino acids in length. The opportunistic pathogen Mycobacterium smegmatis is resistant to rifampin because of the presence of a chromosomally encoded rifampin ADP-ribosyltransferase (Arr-ms). Arr-ms is a small enzyme whose activity thus renders rifamycin antibiotics ineffective [2].	25.00	25.00	41.70	41.30	22.50	20.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.17	0.72	-4.07	15	184	2009-11-19 18:25:00	2009-07-14 16:38:57	3	4	154	1	54	158	11	99.60	62	64.61	CHANGED	PFaHGTKADLpsGDLLpsGapSNYpcs.+hhNHlYFTuTLDAAsWGAELAs....G-G+sRIYlVEPTGsFE-DPNlTDKKFPGNPTRSYRSpcPLRlVGElTcW	..PFaHGTKAcLtlGDLLssGahSNacss.+hhsHIYFTAhh-uAsWGAELAh............u-G+.sRIYIVEPTGsFEDDPNlTDKKFPGNPT+SYRopcPLRIVGElpDW..........	0	20	40	51
+11954	PF12121	DD_K		Dermaseptin	Mistry J, Gavin OL	anon	pdb_2jx6	Domain	This protein is found in eukaryotes. Proteins in this family are typically between 30 to 76 amino acids in length. This protein is found associated with Pfam:PF03032. This domain is part of a dermaseptin protein which is used as an antimicrobial agent. The full protein is almost completely defined in an alpha helical domain. It creates high levels of disorder at the level of the phospholipid head group of bacterial membranes suggesting that it partitions into the bilayer where it severely disrupts membrane packing.	20.90	20.90	20.90	22.10	19.80	20.60	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.06	0.72	-6.41	0.72	-4.01	14	62	2009-07-14 15:43:20	2009-07-14 16:43:20	3	2	15	2	0	61	0	24.50	56	52.07	CHANGED	uLWssI....Kphu.pA...AGKAALsAVs	.uLWpslh...KphG.cA........AGKAALGAVs.......	0	0	0	0
+11955	PF12122	DUF3582		Protein of unknown function (DUF3582)	Assefa S, Bateman A	anon	PFAM-B_2087 (release 23.0)	Family	This domain is found in bacteria, and is approximately 130 amino acids in length. It is found associated with Pfam:PF01694. There is a conserved ASW sequence motif. This domain has a single completely conserved residue F that may be functionally important.	22.00	22.00	22.00	22.20	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.48	0.72	-4.03	32	749	2012-10-01 21:59:08	2009-07-14 16:54:12	3	2	745	15	96	340	17	98.80	56	35.72	CHANGED	MlclhslsNsRhAQAFlDYhtsps.Ichplhs.....pspu.hslalh.ccpphspsptElppFlpsP...tcs+Y.tASW-sGsTps.phc.Yps..o......hlst..h...hspAGPlTLs	.............MhhITSFuNPRlAQAFVDYMATQG.VlLTIQQ.................csQo...DlWLA.DESQAERVRuELARFLENP...uDPRYLAASWQuGcTsS.GL+.Y+Ra.P......FhAsL.....RcRAGPVThl.....................................	0	16	36	66
+11956	PF12123	Amidase02_C		N-acetylmuramoyl-l-alanine amidase	Mistry J, Gavin OL	anon	pdb_2ir9	Domain	This domain is found in bacteria and viruses. This domain is about 50 amino acids in length. This domain is classified with the enzyme classification code EC:3.5.1.28. This domain is the C terminal of the enzyme which hydrolyses the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.	21.40	21.40	21.70	26.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-7.91	0.72	-4.32	16	260	2009-09-10 17:34:38	2009-07-14 16:57:45	3	4	95	2	9	151	0	44.60	42	18.36	CHANGED	phshpu+llhps..sGLsYh.Tcshss.spLc+hptWLDp+...GWaYEh	...pLthsuphIlps..-GLsYhlT-spss.spLcthTsWLDp+...GWaYEh.	0	0	4	4
+11957	PF12124	Nsp3_PL2pro		Coronavirus polyprotein cleavage domain	Mistry J, Gavin OL	anon	pdb_2kaf	Domain	This domain is found in SARS coronaviruses, and is about 70 amino acids in length. It is found associated with various other coronavirus proteins due to the polyprotein nature of most viral translation. PL2pro is a domain of the non-structural protein nsp3. The domain performs three of the cleavages required to separate the translated polyprotein into its distinct proteins.	25.00	25.00	29.60	100.60	24.50	18.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.02	0.72	-4.41	5	173	2009-07-14 16:00:46	2009-07-14 17:00:46	3	5	66	2	0	152	0	65.90	97	1.12	CHANGED	SEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTlESPlEFHLDGEVLPLDKLKSLLS	SEEHFVETVSLAGSYRDWSYSGQRTELGVEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLS.	0	0	0	0
+11958	PF12125	Beta-TrCP_D		D domain of beta-TrCP	Mistry J, Gavin OL	anon	pdb_2p64	Domain	This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with Pfam:PF00646, Pfam:PF00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein.  Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.	25.00	25.00	26.20	26.30	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.00	0.72	-4.35	6	176	2009-07-14 16:02:24	2009-07-14 17:02:24	3	10	86	3	91	159	0	39.60	79	7.41	CHANGED	hcYFspWSEu-QVDFVEaLLSRMCHYQHGpINuaLKPMLQ	.....lKYF-QWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQ	0	20	27	54
+11959	PF12126	DUF3583		Protein of unknown function (DUF3583)	Assefa S	anon	PFAM-B_2092 (release 23.0)	Family	This domain is found in eukaryotes, and is typically between 302 and 338 amino acids in length. It is found in association with Pfam:PF00097 and Pfam:PF00643. Most members are promyelocytic leukemia proteins, and this family lies towards the C-terminus.	22.70	22.70	23.50	24.40	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-12.04	0.70	-5.36	3	98	2009-07-14 16:17:51	2009-07-14 17:17:51	3	7	36	0	23	120	0	236.60	58	40.35	CHANGED	LDTMTQsLQEQDRTFGAAHAQM+SAIGQLGRARADTEEhIRERVRQVVAHVpAQERELLEAVsARYQRDYEEIAGQLGRLDAVLQRIRTGSALVQRMKLYASDQEVLDMHuFLRKALCpLRQEEPQSL+AsV+TDGFDEFKVRLQDLlSCITQGpDAAVS++ASPEAASTPRD.....PlsTDsPE-l.p......sQhQA.tL......AhVpsVPGAHPVPVYAFShQsPohREEuSNTTTuQKRKCSQT-CPRKlIKMESEEGcEuRLApSSPEQPRPSTSKAVSPPHLDGPPSP+SPVlccElhLPNSNHVTSDsGETEERV..................VVISSSEDSDAENss	................LssMTQsLpEQ-tsFsusHAQM+uAluQLs+sRu-TEELIRtRVRplVsHlpAQE+ELL.EuVpsRYQRDYcEhAucLuRL-AVLQRIRsGusLVpRMKpYASDQEVLDMHuFLRpALs+LRQ.EEPQsLpAsV+TDG..F-EFKlRLQDL.SCIT..QGpsuuss+p.AsPEusssPp-.....shss-....................................................................-sosTssspKR.Ksspsp..CsRKlIKMESpEt.pEsRLApSSPEQPtPSTS+AsSPP+LDG.sss.cSss.tp-h...sssNHssu.s.s...u.Estcpl..................hllusSccsct....s.................................................................	0	3	3	7
+11960	PF12127	YdfA_immunity		SigmaW regulon antibacterial	Assefa S	anon	PFAM-B_2114 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are about 330 amino acids in length. The operon from which this protein is derived confers immunity for the host species to a broad range of antibacterial compounds, unlike the specific immunity proteins that are linked to and co-regulated with their antibiotic-synthesis proteins.	26.70	26.70	26.90	39.30	25.10	26.60	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.00	0.70	-5.53	22	608	2009-07-15 08:13:42	2009-07-15 09:13:42	3	2	588	0	119	350	208	312.90	69	96.50	CHANGED	lhhlllsslhllhlhlhFs.FlPhs..LWIoAhuuGVclulhsLlGMRLRRVsPppIVpshIpApKAGL.....c.lssspLEAHYLAGGNVspVVcALIAAp+As.IsLsFcRAsAIDLAGRDVLEAVQhSVNPKVI-TP........slsAVAKDGIpL+sKARVTVRANIc+LVGGAGEETIIARVGEGIVooIGSussHKpVLENPDpIS+sVLsKGLDuGTAFEILSIDIADlDVGcNIGAcLQsDQAEADKclAQAKAEcRRAMAVApEQEMpAhlpEMRAKVVEAEAEVP+AhApAhRcGpl.GVMDYYphpNlpADTpMR-uIu+tu......cs	.......ls.hlllslllllhL.llh.Fo.F.V..P..lG..LWISALAAGV+VuIh.TLVGMRLRRVsPp+llsPLIKApKAGL...........s.losNQLEuHYLAGGNVDRVVDALIAApRAs.I-LsFERAAAIDLA....GRDVLEAVQMSVNPKVIETP........hluuVAhsGIE.VKAKARlTVRANIsRLVGGAGEETIIARVGEGIVSTIGSScpHpcVLENPDsISKTVLsK.GLDuGTAFEILSIDIADVDIG.....KNIGAcLQT-QApADKpIAQAKAEERRAMAVApEQEMKA+VQEM+AKVVEAEuEVPlAMAEALRsGNl.GVhDYYNhKNIpADTsMRsuIuKts.ct...........................	0	66	99	112
+11961	PF12128	DUF3584		Protein of unknown function (DUF3584)	Assefa S, Bateman A	anon	PFAM-B_2142 (release 23.0)	Domain	This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.	28.70	28.70	28.70	28.70	28.40	28.50	hmmbuild  -o /dev/null HMM SEED	1201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.17	0.70	-13.81	0.70	-7.23	10	142	2012-10-05 12:31:09	2009-07-15 13:32:20	3	7	123	0	45	146	29	971.80	22	91.34	CHANGED	ILIDoa..lp.GpV.ELsLsGHTplsGTNuuGKTTLhRLlPlFYGEtPS+lVsps.tRcsFs-aYLP+-SShllYEYpR.sG.QLCpsVhspt.uDG+GVpYRFIcuGYcpshFlsupptthhtshossElt+phRpsGhssSphLs.hccYRuIIQN-Rohh...GpcppELRsLAppFSLssu-pslpHIDKlssushsKptch-slKsMlsAIhp-...Dsssssppp...lsppclpsWlpDhpthpulpplpschcclpp-aspLpSlhh+LptL+stlhucppplppcQp-ppstppchcpplcpL--phpEspcchsp-lSstcuclstpcscL-tl-cp+tsapDsDlEphptDh-plPphcs-hpplptplctlpsptpclppca-cppptlcppppcclpshcsc.tpslREp+sct...+sstccshpuLEuphppQhcttppchsccphclcpplschctphsssshosEphtslpts-pclccAcEphppupsshppLpscppph+pcRDpApctLpcusppLpch+sphp-lcpQLhPpusSLlcFL.RsE..AssWccsIGKlIssELLcRTDLsPphspus..s.s..sLaGlpLDLpsl-sP-astsEp......pLRp+Lsth-csLpoApspppptEcpLsplNspl-ptpcslscAppuhcpscpcLpRLpsppcshpc+lppAlpc++ppsppplspLcpplKtLpccppsalcphc-chpEtphppptthpsV.ushDsQlspLpptlputcsss+Aclcphccthcs-LpspslDspsltcLcpclcsLcppIppspsccpclpcYcsahpcsWhp......c+spLttplpslcsuhp-LppcLsptppsh+pctpcLppppcAs-cthsplsEslp.pl+shhcpL.AplphstssspAs....hplu.phcth--hpppccRLtsslcpalE+Fcsll....sc+SGSsLhEsWp+h.ppcsshlu-+ul...p.hch..l.hlpplhsll..ssQpppulh-hsslhusslscFYpsLsshsRRIcohS++Lo+cVssptphEulu-lsVclpo+l-EL-aWssLctFsc...sFcpWpcp..-Ghs-lPc-phssuMpRlsshLss.uuhshulssLl-lElsLpEsGpclhIRN-+QLpcsSSpGhoYLIlhphhlGFsphLRG..cusspIpWPVDELGpLctsNlc+LhshhssNpIolLSAhPssDsclLsLFp++Yhlcc	...................................................Eltlc.GpsphhGTpusGKoTl.Rhl.hFY.st..p+l.l.pp..+cuFpcaYhPhssSaIlYEh.+tsG.....hhpslht.t.spu..tlp.aRFls.tsap.p.....alpppp.....hshs.tphhpphh.t..t.slthothls.hpcYRsII..sstp............t.chh.h..tpaulhp..utpphppI.+.hh.psl.hspchch-hlKp.hlht..h.p-.......sh......ppp.........p.pchptWhp...c.p......h.....p..t..h...........hp.ph.ppltpt........hppl.th.p.plt.thttthtts.p.ttpp...hppp.pchptphpphpcp...hp...p.ppchppchsthptslsthpppLctlpppctta.tpts.Ipphhtc.h.pph.....phppch....pplppphphhspphp-lpstapt...h...hppltpph....p.......p........hpt....hptp.....sph....ppphtpt........tpttcpphpthppph.......ppphp..ttht.ph...p..ppp.ph.......p..p.htph..ch.....p...h....p...phph..pp-th..phth.......hc......ttl..pp....t.p.p....ptp....ph.ptt...h..p...p...h..p....tp.....pph.ptp....hp........pt.t...p....tl.pt....h....p.phpp........h....ptpltplpthL.sp..psoLhpaL.ppp....t.sWcps.lGKVls.c.l.Lhp..p-LpPphstt.....s....t.........shaGlp....l..s....Lpsl.....p.....h.....s.....phhtpcp.......phptp...hpthpp.th.tp....h.p.....p.....t....pp.h....cppl.tt....h.pt....p....lpp....hpp.......ph....s.tp.......t...thc.p..p.t....ch....pphhspp....pp.ppchppthptphpphtpplpphptplpphppphpphhp.t....ccphtphc.....phpt.hpph.sthcpphttlptphpp....tppphppphpthcp.hp...p-L.pupGsD.ttpltphcppltplppplphhcppcs.lhc....Ypc.hppha.........tp.phppphtth.cpthpphppphpthtpphptphpph.ppphpt.ctt.tphp..p.hp.......t.p.hh.p.....tp...h.........s....pt...t.php..........ht...phh.pphpph...h.ph...tt...hhtp...hpphht.phpt.h.......st...th.c....h.t...........t...sct...........hph........h..l.p.hhp.........sp..p.l.p.hp..h..h.pl.tt.hthhtphptcltt.stclsp...th.t.....hthlt....p...thp.h..sp.p..h.t.....h...h..lp.h.t.......th.....t.h..t.......t..thst........hh..htphhp..h.t..tt.....thtltphhclphplhEssp.c.hhhh..cpltpsuSpGhshLlhshh.lhhhphh+t.....ts.....phtlph.hDElGpLp.pNlptlhphhppppI.llsu.P.s..................................................................................................................................	0	8	23	38
+11962	PF12129	Phtf-FEM1B_bdg		Male germ-cell putative homeodomain transcription factor	Assefa S	anon	PFAM-B_2140 (release 23.0)	Domain	This domain is found in bacteria and eukaryotes, and is typically between 101 and 140 amino acids in length. Phtf proteins do not display any sequence similarity to known or predicted proteins, but their conservation among species suggests an essential function. The 84 kDa Phtf1 protein is an integral membrane protein, anchored to a cell membrane by six to eight trans-membrane domains, that is associated with a domain of the endoplasmic reticulum (ER) juxtaposed to the Golgi apparatus. It is present during meiosis and spermiogenesis, and, by the end of spermiogenesis, is released from the mature spermatozoon within the residual bodies [1]. Phtf1 enhances the binding of FEM1B -feminisation homologue 1B - to cell membranes. Fem-1 was initially identified in the signaling pathway for sex determination, as well as being implicated in apoptosis, but its biochemical role is still unclear, and neither FEM1B nor PHTF1 is directly implicated in apoptosis in spermatogenesis. It is the ANK domain of FEM1B that is necessary for the interaction with the N-terminal region of Phtf1 [2].	21.10	21.10	21.10	21.20	20.70	20.30	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.92	0.71	-4.88	3	198	2009-07-15 12:34:29	2009-07-15 13:34:29	3	2	71	0	83	159	0	143.60	60	22.68	CHANGED	S+lcDAluWYQKKIGAYDQQIWEKSIEQ+pIKGL+NKPKKsGHlKPDLIDVDLVRGSTFAKAKPElPWTSLTRKGlVRVVFFPlFu+WWlQVTShRIFVWLLlLYhLQVIAlVLYsh.......sQp.HIVslSEVLGPIsLMLLLGTVHCQIVSTphs+PssssG	..................p.p-hlsWYQKK..IGAYDQQIWEKSlEQ.ppI.........K......Gh....+NKPKKhuHlKPDLIDVDLlR..GSsFAKAKPE....PWTSLTRKGlVRVVFFPhF.pWW.lQVTSh.hIFhaLLlLYl..hQ.VhAlVLah...........................................hs......lsloEVlGPlhLMLLlGTVHCQIVSTphs+sshss...............	1	14	21	46
+11963	PF12130	DUF3585		Protein of unknown function (DUF3585)	Assefa S	anon	PFAM-B_2156 (release 23.0)	Domain	This domain is found in eukaryotes. This domain is typically between 135 and 149 amino acids in length and is found associated with Pfam:PF00307.	23.20	23.20	23.30	23.70	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.74	0.71	-4.33	25	600	2009-09-11 08:12:16	2009-07-15 13:54:22	3	17	92	0	329	593	0	135.50	35	15.02	CHANGED	hhsspplpp-LpplEpp.csLEtc..GVtlE+pLRst.t.............sc......p--pLhh-WFpLlpcKshLlRREuELhhhtpphpLEccpspLcpELRthhuht-tpKTpt-cp+EctLlpcllplVppRstlVcsL-pcRlREpcEDcplcp	..................................................tp.lptplptlEpp.ctl-tc..ustlEctLRstht................................spp......p--plht-WFpLlpcKssLlRc-sE.............Lhhh.t.c..-..hcLE.c+.tpLppELRphh.sh..t.......-.......t.p..KTptc....cp+Ep.tLlpcllplVppRDtLVppL-p.....pRh..p.-tEEDp.ht.t.............................................	0	63	93	196
+11964	PF12131	DUF3586		Protein of unknown function (DUF3586)	Assefa S	anon	PFAM-B_2164 (release 23.0)	Family	This domain is found in eukaryotes. This domain is about 80 amino acids in length and is found associated with Pfam:PF08246, and Pfam:PF00112.	25.00	25.00	27.50	27.20	24.00	21.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.91	0.72	-10.06	0.72	-3.93	16	127	2009-07-15 13:00:10	2009-07-15 14:00:10	3	3	28	2	21	137	0	77.40	43	21.85	CHANGED	supuPoPsP.oTts......PtssslhQhhChDhtCpcGCpcsslPsspCl.hsGGGSshspCssppVhhpsY.pSscCoGs	....................s.s.usTPsPoTpopppA....Pp.sshhsQhhCTDttCppGCcpssls.TspCl.ssuGuSuhssCGspplp.psY.oospCoGs........	0	16	21	21
+11965	PF12132	DUF3587		Protein of unknown function (DUF3587)	Assefa S	anon	PFAM-B_2181 (release 23.0)	Family	This protein is found in viruses. Proteins in this family are typically between 209 and 248 amino acids in length.	25.00	25.00	40.90	40.40	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-11.48	0.71	-5.08	52	74	2009-07-15 13:11:26	2009-07-15 14:11:26	3	1	7	0	0	73	0	182.50	31	81.44	CHANGED	ppstsss.s.s...........pt.hlPhchl..hhhucFlpFt-atphlpshhPptt.s....lptpLap.hST+phpssFlNGKpLpIcYNFDspRhcc-RlLIsl-oLlPlFGGlh...ss.shcpFsolscLpsFVchcVHLstCS.shpa.ASCsC..HLhsspt.t..........pthspP....sssCpps.HFHHaCupHVttWLphaLtssIlh+Esp.ph.ascphsc	.....................................htt....................s..phh..h.hsphhph.ph.phht.hhsptt.s....lptpLap..hST+phpssFlNGKpLclcYNFDssRhcc-Rl.LIslcoLhPlFGGlh.......ss...shcpFsolsclpsFlctcl+LstCo.shpa..A.oCsC..+hhspptp....h.....pthhps..........sstCpht.HFHHaCspHVttWLphaLtshIhhpEsp.thhtp...................	0	0	0	0
+11966	PF12133	Sars6		Open reading frame 6 from SARS coronavirus	Assefa S, Bateman A, Coggill P	anon	PfamB-2188 (release 23.0)	Family	This family is found in Coronaviruses. Proteins in this family are typically between 42 to 63 amino acids in length.	27.00	27.00	63.50	63.30	17.90	16.70	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.93	0.72	-4.29	6	86	2009-07-15 13:35:43	2009-07-15 14:35:43	3	1	82	0	0	15	0	57.60	96	98.29	CHANGED	MFHLVDFQVTIAEILIIIMRTFRIAIWNLDVlISSIVRQLFKPLTKKNYSELDDEEPMELDY	MFHLVDFQVTIAEILIIIM+TFRIAIWNLDVIISSIVRQLFKPLTKKNYSELDDEEPMELDY.	0	0	0	0
+11967	PF12134	PRP8_domainIV		PRP8 domain IV core	Mistry J, Gavin OL	anon	pdb_3enb	Domain	This domain is found in eukaryotes, and is about 20 amino acids in length. It is found associated with Pfam:PF10597, Pfam:PF10596, Pfam:PF10598, Pfam:PF08083, Pfam:PF08082, Pfam:PF01398, Pfam:PF08084. There is a conserved LILR sequence motif. The domain is a selenomethionine domain in a subunit of the spliceosome. The function of PRP8 domain IV is believed to be interaction with the splicosomal core.	25.00	25.00	34.00	33.00	19.10	18.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.53	0.70	-5.01	14	350	2009-07-15 15:36:11	2009-07-15 16:36:11	3	45	291	12	240	338	7	220.60	76	10.05	CHANGED	EsaLNSpNYuELFuNps.paFVDDTNVYRVTlHKTFEGNlsTKPlNGslFILNP+oGQLFLKVIHTSVWAGQKRLuQLAKWKoAEEVsALlRSLPhEEQPKQlIVTRKuMLDPLEVHh.LDFPNIsI+sSELpLPFtuhhKl-KluDlVLKAsEPpMVLFNlYDDWLc..slSsaTAFSRLILlLRuL+lNtE+s+hIL+PshsllTpspHlWPoh.oDppWlcVElpL+DLILsD	........................EPaLsSQNYuELFSNQI.hWFVDDTNVYRVTIHKT......FEGNLT.T.KPINGAIFIFNPRTG.....QLFLKIIHTSVWAGQKRL.GQLAKWKTAEEVAALIRSLPVEEQPKQlIVTRKGMLDPLE...VHL.LDFPNIlI+GSELQLPFQAshKlEKhGDLILKATEPQMVLFNLYDDWLK..oISSYTAFSRLILILRALHVNs-+sKlIL+PDKTslT.psHHIWPoL.oDE-WIKVElpL+DLILsD............	0	89	137	200
+11968	PF12135	Sialidase_penC		Sialidase enzyme penultimate C terminal domain	Mistry J, Gavin OL	anon	pdb_2vo8	Domain	This domain is found in bacteria and eukaryotes, and is about 30 amino acids in length. The protein from which this domain is found is a sialidase enzyme which is used by virulent bacteria as a toxin. It is the penultimate C terminal domain.	20.40	20.40	21.20	21.80	20.00	18.50	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.65	0.72	-6.69	0.72	-4.22	23	64	2009-07-15 15:38:49	2009-07-15 16:38:49	3	6	14	1	18	69	0	24.80	37	4.57	CHANGED	hsDsElass-pphppNcEIYsLspI	....sDsElYtsEphhphNpElasLspl.	0	2	6	18
+11969	PF12136	RNA_pol_Rpo13		RNA polymerase Rpo13 subunit HTH domain	Mistry J, Gavin OL	anon	pdb_2waq	Domain	This domain is found in archaea, and is about 40 amino acids in length. It has a single completely conserved residue E that may be functionally important. It is found in the archaeal DNA dependent RNA polymerase. The domain is a 'helix-turn-helix' (HTH) domain in the Rpo13 subunit of the RNA polymerase. This domain is involved in downstream DNA binding, and the entire subunit has also been implicated in contacting transcription factor II B.	25.00	25.00	33.50	33.50	18.50	17.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.13	0.72	-4.26	7	23	2009-07-15 15:39:56	2009-07-15 16:39:56	3	1	23	4	11	17	0	46.10	56	46.09	CHANGED	cEtth.EE-EEsEhss....lslpslEhhh+sTElW-pLlpGcl	...............t.EEpcVE.....EssE-EhPp....LSIQDIELLMKNTEIWDsLLsGKI	0	5	5	9
+11970	PF12137	RapA_C		RNA polymerase recycling family C-terminal	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2201 (release 23.0)	Domain	This domain is found in bacteria. This domain is about 360 amino acids in length. This domain is found associated with Pfam:PF00271, Pfam:PF00176. The function of this domain is not known, but structurally it forms an alpha-beta fold in nature with a central beta-sheet flanked by helices and loops, the beta-sheet being mainly antiparallel and flanked by four alpha helices, among which the two longer helices exhibit a coiled-coil arrangement.	26.80	26.80	27.80	27.80	26.40	25.90	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.95	0.70	-5.62	50	1007	2009-07-15 16:36:59	2009-07-15 17:36:59	3	5	973	2	150	632	98	352.20	58	38.01	CHANGED	pDIpIHVPYhcsoAQphLhcWYccGLNAFpcTCPsGpslacpatppLpshLt..ss....spssh-pLlppopptpppL+spLEpGRDRLLELNSsus-pAppLs-sItppDs.sspLssFhhplFDhlGlcQE....Dpu-sullLcP.....o-+Mhsss.aPGL..s...E-GhTlTF-RcpALuREDhpFloWEHPhlpsuhDllhou-hGsoululLcNcuLPsGTlLLEhlasl-upAP+sLQLsRFLPsTPlRlLlDppGssLusplsa-shscpLpsls+phApclVpthpsplcpllppu-phupsphptllppAppphpppLssElpRLpALpsVNPsIRp-EI-tLcppppphhshLspAplpLDAlRllVss	................+DIQIHVPYLEcTAQulLsRWYHEGLsAFEcTCPTGRslYDuhhscLIsh...LAuP......pps-uaD-LIcpsRcp+-uLKAQLEQGRDRLLElHSNG.GE+AQtLA-u......Ip.................EQDs...DTsLlsFAhsLFDIlGIsQ-....DRG.-N...hIVLTP.....SDHMLV..PD.FPGL...s..EDGhTI..TFDR-sALuREDsQFITWEHPlIRsGlDLILSGDsGooslSLLK.N..KALPVGTLLlELlYVVEAQAP.......K.........pL.........QLsRFLPPTPlRh.L.L.Dc.....NG.NNLAuQVEFEoFNRQL..su..VNRHouSKL.....VsAV.Qp-VHsllphGEsplEppAcuLI-sA+p-A-pcLouELuRL..c.AL..+.AVNPNI.R.DDElsAl-spRpplhpsLsQ.AuaRLDALRLIVVs..........................................	0	35	65	113
+11971	PF12138	Spherulin4		Spherulation-specific family 4	Assefa S	anon	PFAM-B_2198 (release 23.0)	Family	This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 250 and 398 amino acids in length.  There is a conserved NPG sequence motif and there are two completely conserved G residues that may be functionally important. Starvation will often induce spherulation - the production of spores - and this process may involve DNA-methylation. Changes in the methylation of spherulin4 are associated with the formation of spherules, but these changes are probably transient. Methylation of the gene accompanies its transcriptional activation, and spherulin4 mRNA is only detectable in late spherulating cultures and mature spherules. It is a spherulation-specific protein.	28.50	28.50	28.60	36.00	25.90	28.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.97	0.70	-4.95	44	221	2009-07-15 17:01:16	2009-07-15 18:01:16	3	11	122	0	141	236	0	229.90	25	69.40	CHANGED	tplllPlYl.YP....tssss.Ws.L.................t......................lsshPsltaslllNP.ssGPGtt.....sDssYssslscL....ptss...spllGY..............................VpT....sY..usRsls-Vtp-lspY.......................................ssW.t....................................................................................................................................................................................................................................................................................................................................................................................................thslcGIFlDE..ssssht...sphsYhpplsshl+s.................................htssthVlhNPGs.hP......tssahs...h..u.DhhVsFEssassa...sshsst....t..hlsshs..ts+hst......llaul..................P.............ssspltshsp.phpptu..uhlalT........shsss....Ypshs..shWpp.........hlsslss	...........................................................h..lhlPhYh.aP...........hsss..Ws.L...........................................hss..ssh..hhlllNP.ssGP........Gtt......sDssahpslspL.................phss....scllGY..............................VpTsY............usRshsplhp-lppY.......................................tsW..................................................................................................................................................htlcGlFhDE....sssph...............stl.sahpplsshl+s.................................hts.s..t.hVlhNPGs.hs..........ssahs........h....uDhh.Vs..FEssassa........tts.sst.........t...hhsshs.....p+hstllasl.....................P.............................t.pphttlhp.thtp.ts..uhlahT......................s....sss.....atshs..shapt.ht....t....................................................................................................	0	41	82	114
+11972	PF12139	APS-reductase_C		Adenosine-5'-phosphosulfate reductase beta subunit	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2202 (release 23.0)	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 112 to 142 amino acids in length. This family is found in association with Pfam:PF00037, and has a conserved FPIRTT sequence motif. The whole beta subunit has the enzymic properties of EC:1.8.99.2.	25.00	25.00	25.50	39.80	23.00	18.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.87	0.72	-3.84	43	261	2009-09-11 09:55:26	2009-07-16 09:44:11	3	10	227	18	53	254	806	83.70	48	62.12	CHANGED	lRGYADFsPhGuoshPhRuo-c..IMWTlKFRNG.slKRFKFPIRTTsEG...ohsPhtGhst...ssDL.cophLhoEst...................tthclsssc	.lRGYADFsPhGuolhPhRus-s..IMWTlKFRNG.slKRFKFPIRTTPEG...oh.ssa.s.uhst...sscL.csp.lLasEst...................ht......................	0	25	44	50
+11973	PF12140	DUF3588		Protein of unknown function (DUF3588)	Assefa S, Bateman A	anon	PFAM-B_2205 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 866 amino acids in length, and the family is found in association with Pfam:PF02820. The exact function of this family is not known.	25.00	25.00	25.40	30.90	24.30	24.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.58	0.71	-4.02	15	369	2009-07-16 09:36:54	2009-07-16 10:36:54	3	15	82	0	178	312	0	113.30	42	17.18	CHANGED	ssssVslYlNK+sssGPaL-+p+ltpLPsaaGPGssslVLppslQuslssAYpsppVhphLp..ps...GGE..slpApa-GKsaplpLPs...VsosshVh+FLcplCppLp....C-NLFSspPho	..........................................ssp.tlYlN+pstsGPaLs+p+ltpLPpphGPupsslVLpps.lpthIssAacsppVhphLp....ps.....sGp....slpAp.acGcpa...p...hslss...VposshVhcFlcplCppLp....CsNLFusp.h....................	0	23	35	88
+11974	PF12141	DUF3589		Protein of unknown function (DUF3589)	Assefa S	anon	PFAM-B_2240 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 541 and 717 amino acids in length. The function of this family is not known,	25.00	25.00	50.60	44.50	17.60	17.10	hmmbuild  -o /dev/null HMM SEED	498	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.05	0.70	-12.94	0.70	-6.27	31	145	2009-07-16 10:10:52	2009-07-16 11:10:52	3	2	27	0	113	176	2	461.20	29	74.19	CHANGED	ppCpp.lphptslplopspshs....ssLcplhspllpp.p....shap-lpshF.tclpcphccphl.cK+Wa+FuGSSVWL-pYGVHaMlSRllYS.pGh+spPhlSLhYsQlFDcNWpElps.hpLllP...................h..sctsac.hp...FPsFLPIPhaashc...ppppaYGPEDPRllLhc.....NphGh-EPllVaNua+cc.ls......................p........ahRoMFhsaPap.p................tp..as+shEL+lcsppctppEKNWTPF..ls..........pt.pshDpalaFlYpassLclL+CsL....ssus......Ccaha+......phsspsplGsLRGGTpLlslsphh...........................thspsRclWlGaARuHlcpCGCGpsMYRPNhllLs+s..................spaclualSShlsFslsl.sWshp.............csh....Cts..tsVLIPNuISpWslpp.........................................t.t..hpDhhTlolShADposcllal+GlLppIhsls................................t...htppppttttsshtlcCAlptSpca	...........................................pCpp.lphptp..lpl.op.t.h...h.p....ssLtplhpplhpp.p...........hhpclpshF....clp.p.............p............pphl.....cK+Wa+FuGSSVWLcpatVHhMlSRllYS.pGt+spPhlSLlauQlFDcsWpElp.s.hpLh.lP................................................................tphphp..hp......aPphLsIPhhhs.p.....tptpahGPEDPRllLhc.....Np.Gh-EPlllFNhhcpp.hp.......................................hRuMFhhhPap.......................................sclhcLplpsp.pht.phEKNWoPFhs................t.tpttcsplaFlYpapsLclLKCsL....ssu.................Cphhac.........t.pppspsGslRGGTpllslsphhs.........................................h.ps+plWlGFsRsHlppC.GCGpphYRPphhllscs......................p.spaplshlSs.lsFslslhsWs.t.................pshCss..tNlLIPNuIu.Wpltp........................................................................p.thpDYhslolStuDtsspllpl+GlLphlhpl...........................................pttpt...pp..hpCsh..u.pa.......................................................	0	17	53	113
+11975	PF12142	PPO1_DWL		Polyphenol oxidase middle domain	Assefa S	anon	PFAM-B_2219 (release 23.0)	Domain	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length, and the family is found in association with Pfam:PF00264. Most members are annotated as being polyphenol oxidases, and many are from plants or plastids. There is a conserved DWL sequence motif which gives the family its name.	20.60	20.60	20.60	21.00	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.59	0.72	-4.45	39	355	2009-07-16 12:13:27	2009-07-16 13:13:27	3	8	124	8	85	375	0	52.10	52	10.25	CHANGED	DhTDsDWLsupF.lFY.DE..NsphVRV+V+DsLD.sc+LGYsY.pcVs..lPWlsuKPssp	....DhTDsDWL-u.uF..hFY.DE..pucLVRV+VRDsLD.spp..LtYsY.Q-Vs..lPWLss+Pss...............	0	16	67	78
+11976	PF12143	PPO1_KFDV		Protein of unknown function (DUF_B2219)	Assefa S	anon	PFAM-B_2219 (release 23.0)	Domain	This domain family is found in eukaryotes, and is typically between 138 and 152 amino acids in length. and the family is found in association with Pfam:PF00264. Many members are plant or plastid polyphenol oxidases, and there is a highly conserved sequence motif: KFDV, from which the name derives. This is the C-terminal domain of these oxidases.	20.60	20.60	20.60	20.60	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.70	0.71	-4.26	32	337	2012-10-01 19:33:20	2009-07-16 13:34:11	3	12	111	0	86	438	1	119.10	40	22.90	CHANGED	FPl.sL-cs.lp.spVpRP+.poRoc+E.K--EEEVLVI-GIEh-psh.h.lKFDValN.D-scsss..ssspsEFAGSFlslPHt.+pp.......t+p...hpTsh+LGlo-LLEDLsA-sD-.ollVTLVPRsGs..s.l.pIsGlcI-h	......................FPh.sL-ps.lp..ssVpR.Pp.tsR....occE....K--E..EEVLV.I-GIEhccc..h..VKFDValN..s-sstss..sssssEaAGSFsplPHt..ppt..........ttp......hpoph+huls-LL.-Dlss-s...Dc..ollVolVP+hGs..t.l.slsulpIth.................................	0	9	70	79
+11977	PF12144	Med12-PQL		Eukaryotic Mediator 12 catenin-binding domain	Assefa S	anon	PFAM-B_2250 (release 23.0)	Domain	This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.	25.30	25.30	25.90	25.90	19.70	17.40	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.72	0.71	-4.94	4	106	2009-07-16 15:03:35	2009-07-16 16:03:35	3	6	38	0	42	87	0	181.20	53	11.28	CHANGED	PP-LhQsts.G...RlsYtQpuMNMYTQNQPLPPGGPGLEPPYRPsRsP.MNK.MPsRPNYTuhMssMQ.usMsslMGL-K...QYsMsaKPQPsMPQGQhLRpQLQsp..sQuhIGQ.QlRQMTPNpsYouMQsS....QGYToaGSHMGMQQHsSQsGGMsPsSYGsQsFQuTHPAsNPslVDPpRQLQQRPSGYVHQQAP.uYsHshQsTQRFs.HQs	............................hhpp..........phsY....t..t.p.GhasQNQPLPs..GGPRlD...s..aRP.sRhs..hpK.hssRP..sYsuhh.P.............ssM...su.......lhul-s...p..pp..h.hp.ppQPshsQGQp......L.R.pQ......LQs+..............pQ.......GhhG.Q...p.......l....+Q.hsPs...s...p.Y.GLQsu.......Q....GYTsYsSHhuLQQHs..u...uus..hV..sPSYsupsY.usH..oNPsLhDshRplQQR.PSGYVHQQAP...sYsHsLsuoQ.Rhs.HQ....	0	2	5	16
+11978	PF12145	Med12-LCEWAV		Eukaryotic Mediator 12 subunit domain	Assefa S	anon	PFAM-B_2250 (release 23.0)	Domain	This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.	20.30	20.30	20.30	20.40	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.94	0.70	-6.01	7	175	2009-07-16 15:05:44	2009-07-16 16:05:44	3	10	89	0	108	157	0	397.50	46	22.82	CHANGED	s-FVQSthLuRRLAYhso++Lu........Lls...............................usppspsIpspsssshsssssspsssppsPhphsFo-ahpCspHRslVhtLSsILQsITLpCPoALVW.............shutscopsph.GSPLD+LPlAPSsLPMPst..ssthNppVRtpLhpsEppIK.RuptsEsRWshDKhQpu......AG.shs+VLpTL-sLDsHsF-RhDpsNSlDoLYs+IFsstpscstcpsp.........................................ppD-ulVplLCEWAVSppR.GcHRAMVVApLL-KRQs-l.sphss-S.....ps.D-K-SlsSGuhsssuhPVFQcVLhpFLDspAPsLs-..soppp+spFsNLVhLFsELIRHDVFSHsAYMCTLISRGDLhs...................Tushop.sususpsssstthc-pshtss.chc..ths-S...D..sp.................hhpchpEctpsS.-tssssp..cstpp-.shphshstshs.sRHh.YspHFPlsQ--s..upH..-CNQRhllL	..........................................................t.EFVQSthLSRRLAYhCsR+Lu.......h.Ls...............................................................................................................sspssch.h.s.........s.ss..shsssss.....stssss.sP.phsFsD.hh....CspH.+.s.lVauLSChLQslhLsCPSALVW...................pYuhscs+............ts.GSPLDhLP.lAPSsLPMPtG..sosh...sQQVRs+lhElEpQIKpRGpAVEsRWS...FDKCQEuT........A.GhTIuRVL+.T.LEVLDpHsF-..R..sD....oNS..l-oLhp+IFh.s.s.K.....DspEhs.........................................ssD.-AV.VsLLCEWAVSsKRsGcHRAMsVAKLLE.KRQuElEAE+.sG.-.S..................EshDEKtSl.uSuSluusoh.PlFQsVLlpFLDT...QAP.Lo-...spo.-..p...E+sEFhNLVLLFsELIRHDVFSHshYhCTLISRGDLuh.....................................................sus.spP.oP....sc..ss--...............K....-.t.cht.........t...t...t..........hs..p....h....h-..sp..............................................h..scs....pspsS.pp..s..pp...c.s..c-p........h.p.hh....s....hs.sRH..lpYsoH.FPI...P...--s.....sSH...ECNQRhllL........................................................................................................	0	35	41	73
+11979	PF12146	Hydrolase_4		Putative lysophospholipase	Assefa S	anon	PFAM-B_2243 (release 23.0)	Family	This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. Many members are annotated as being lysophospholipases, and others as alpha-beta hydrolase fold-containing proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.62	0.72	-4.13	137	1506	2012-10-03 11:45:05	2009-07-16 16:11:07	3	13	1223	0	398	8635	1896	80.60	30	22.07	CHANGED	GhpLh.hpp.Whs...s..ss......+uslll.h.H.Gh.s.EHus..+..Ypc.luppLst.pGaslauhDpRGHG.pS.....s......G.....p..Ru...h..hssas..ph..l.c..D.lpph...lp	.........................................htLahpp.W.s...........ps........s+u.l.lhl.h.H...G.....h....t.....E..H..uu.....R..........Y...p......c.....l....s..c....pL...s..p.....s..G......a..s..V..a..u..aDtRG...HG.+S......s........................G...........+G......h......h..s..s.h.s......ph....V.p.Dltphh.t........................................	0	130	239	317
+11980	PF12147	Methyltransf_20	Hydrolase_5;	Putative methyltransferase	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2243 (release 23.0)	Family	This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with Pfam:PF00561. The family shows homology to methyltransferases.	20.10	20.10	20.10	20.20	20.00	20.00	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-11.83	0.70	-5.55	16	478	2012-10-10 17:06:42	2009-07-16 16:16:36	3	6	461	0	55	393	49	296.00	64	53.99	CHANGED	s+hRcFI.ppFspssppsuLhcAD+tGsop-Eu-tLuuPhst.S.psLaWphsRtul+hGGhhScGl+LGhcTGFDSGSTLDYVYRNpspGpG...slG+hID+sYL-AIGWRGIRpRKhHlpELlptAltRL+upGpPVRllDIAAGHGRYVL-ALsststt.....s-uIlLRDYSslNVppGpsLItp+GLssIA+FEpGDAFDtsoLAulpPtPoLAlVSGLYELFsDN-hVtpSLuGLApAlpPGGYLlYTGQPWHPQLEhIARALTSHRsGpAWVMRRRSQAEMDpLVctAGFcKlsQRIDpaGIFTVSlApR	...............................................-KMpsFIsRLYAsps......p+FDYpHEDRsGPSADcaRhLuusPsPhSPhDLsYRhhRtuMKL.hGsaSsGl+LGhsTGFDSGSSLDYVYpNQPQGSs....uFGRLIDKhYLN.SlGWR.GIRQRKs.HLQhLI+Q.AVAcL..+u..cG...hsVRVVDIAAGHGRY...VLDALsscPu.......ls.-I..LLRDYSELNVsQGQtMIAQRGhSups.RFEQGD....A....Fs...sE....-L.uAL......o.P.RPT.L..A.IVSG.LYELFP-.N-.t.V.KNSLAGLAsAIEPG.GlL.IYT..GQPWHPQLEhIAtVLTSHK.D.GKP.WVMRVRSQuEMDoLVccAGF-..KCTQRI..DEWGI..FTVShAVR..............................................................	1	7	25	38
+11981	PF12148	DUF3590		Protein of unknown function (DUF3590)	Mistry J, Gavin OL	anon	pdb_3db3	Domain	This domain is found in eukaryotes, and is typically between 83 and 97 amino acids in length. It is found in association with Pfam:PF00097, Pfam:PF02182, Pfam:PF00628, Pfam:PF00240. There are two conserved sequence motifs: RAR and NYN. The domain is part of the protein NIRF which has zinc finger and ubiquitinating domains. The function of this domain is likely to be mainly structural, however this has not been confirmed.	20.90	20.90	21.60	20.90	20.20	17.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.05	0.72	-4.37	8	130	2009-09-11 05:19:17	2009-07-16 16:52:31	3	11	53	7	70	130	0	88.80	47	12.11	CHANGED	hlDARDsshGAWFEAplVsVo+cssscs............-sllYHVKYDDYPEsGVlplssKslRPRARTlLpWc-LcVGpVVMVNYNsDpPKERG	...............................VDs+DpphGAWFEAplspls..pcs.sst-........................................EDlIYHlKYDDYP.EsGl.lphss+..DlRsRARTll+Wp-LpVGpVVMlNYNs-sPcERG.......	0	14	18	36
+11982	PF12149	HSV_VP16_C		Herpes simplex virus virion protein 16 C terminal	Mistry J, Gavin OL	anon	pdb_2k2u	Domain	This domain is found in viruses, and is about 30 amino acids in length. It is found in association with Pfam:PF02232. This domain is the C terminal of the HSV virion protein 16. This protein is a transcription promoter. The C terminal domain is the carboxyl subdomain of the acidic transcriptional activation domain. The protein binds to DNA binding proteins to carry out its function. Such proteins include TATA binding protein, CBP, TBP-binding protein, etc.	20.10	20.10	20.60	61.80	17.70	18.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.05	0.72	-7.38	0.72	-4.27	2	19	2009-07-16 15:54:40	2009-07-16 16:54:40	3	1	10	3	0	46	0	30.10	85	6.14	CHANGED	DsssYuuLDhADFEFEQMFTDALGID-FGG	.DuAPYGALDMADFEFEQMFTDALGIDEaGG	0	0	0	0
+11983	PF12150	MFP2b		Cytosolic motility protein	Mistry J, Gavin OL	anon	pdb_2bjq	Domain	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are found in nematodes. They complex with MSP (major sperm protein) to allow motility. Their action is quite similar to the action of bacterial actin molecules.	18.80	18.80	22.30	21.50	18.50	16.00	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.36	0.70	-5.75	3	68	2009-07-16 15:56:21	2009-07-16 16:56:21	3	4	10	3	60	63	0	286.80	43	80.89	CHANGED	NPPAKEDTWAFQPIGSPFP-uPVKshGQQNMYVALWYKHGKPIHGRAWNNGGVVECSFPYNKAELTGKpDLGGQIQVLQYKGDHNSLGYWYEWIKYKDRaEKhDct+ElVRCGDSFPILWpcRsGGsLLGYVDNKTElAhFSasGKV-KhpGuALANMhIIsRNLhGGPPaC.Ct.CtusPPsP..llRVpcDEWhDlRpGDPWPTptssV+ALGRoLDTLPGsNPDQYVALWYppGEPVMGRlW.N-GGKlAAsFGWsNpEYs.pcVGSIQLLhhLP-SlRGFDYcWhPFPEAAQFGsKtWpPVHVspHKGNISPuVLplscGKEILGKlDlRNEKAohGYGGKEKlhTGsA.VcsshVLCRKAKA	................................EDpWAatsIGuPFPssPV+s.sppNhYVALWYKHGK.PIHGRu.W..NN.sGVVE.CSFsYpcs..ELosttpLtGQIQlLpY...h.....Gsaps.GFWY-WlpaKc..R.hp.p..-tttph.l.RCGsShPl.hh.p+.ttslLGalD.pTE.AhFu..sGps.p..Gst.hsshhllsRNhhst.st.s.p..t.t......sPPs.s.................+lh..hD-WhDhR.GDsaPstt....V.Ahs+sLsT.sGsp..QYVALWYh.pG.c.P.VhGRsW.sps.GKltAsFuh.spEas.tplGSlQlLhplsspshGa-YsWhsa...............s-uspast..K.ahP.VHl....G.hussll.....tG+plLuplDh+pEphs.huatGKEp.h.Gss.stshhVLCR+th.................................	0	22	28	60
+11984	PF12151	MVL		Mannan-binding protein	Mistry J, Gavin OL	anon	pdb_1zhq	Domain	This domain family is found in bacteria, and is approximately 40 amino acids in length, There is a single completely conserved residue G that may be functionally important. The domain occurs in two types of proteins. In mannan binding proteins [1], it forms a homodimeric molecule which complexes into a homo-octamer. In thiamidases it occurs without repeats but in the presence of other domains. MVL is distinct amongst other oligomannoside binding proteins in that it exhibits specificity for certain tetrasaccharides. Each molecule of MVL has four distinct carbohydrate binding sites.	25.00	25.00	28.20	27.20	21.50	19.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.29	0.72	-7.89	0.72	-4.29	16	75	2009-07-16 15:56:42	2009-07-16 16:56:42	3	5	57	32	26	83	0	38.30	38	13.12	CHANGED	sspApussPshCushGup..WsGQWssTsssuh.....oVsshp	.......tApAssPohCushGGp..WsGQassssssu.t...puspshp....	0	5	13	21
+11985	PF12152	eIF_4G1		Eukaryotic translation initiation factor 4G1	Mistry J, Gavin OL	anon	pdb_1rf8	Domain	This domain is found in eukaryotes, and is about 80 amino acids in length. It is found in association with Pfam:PF02854. This domain is part of the protein eIF_4G. It binds to eIF_4E by wrapping around its N terminal to form the eIF_4F complex. This complex binds various eIF_4E-BPs (binding proteins) to regulate initiation of translation.	18.80	18.80	19.40	19.70	18.10	17.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.59	0.72	-4.08	20	155	2009-07-16 15:57:30	2009-07-16 16:57:30	3	6	127	1	110	160	0	75.70	36	6.16	CHANGED	stpstsspsss.p.ohSphLppLcpApsI...-DlhshpYPpslpuPDschppss....hKYcYsPsFLLQF+cllphpsDsp	...................t..t..sspssp.sspsSthhpsLpoA+hl...-.DltphsYPt..uIpuPsstlNtss....tKa+YstpFLLQFpsVhp-+Ps..h....	3	33	64	96
+11986	PF12153	CAP18_C		LPS binding domain of CAP18 (C terminal)	Mistry J, Gavin OL	anon	pdb_1lyp	Domain	This domain family is found in eukaryotes, and is approximately 30 amino acids in length, and the family is found in association with Pfam:PF00666. CAP18 is a protein which is derived from rabbit granulocytes. It has two domains, an N terminal DUF and a C terminal Gram negative LPS binding domain. This domain is the C terminal domain.	20.50	20.50	20.70	22.80	20.40	19.90	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.98	0.72	-7.10	0.72	-4.30	11	48	2009-07-16 15:57:40	2009-07-16 16:57:40	3	1	33	6	9	49	0	28.10	49	16.48	CHANGED	uchLpKutEKIuctlK+IGQKIKDF..Ftp	.GshhRKupEKIGcclK+IGQ+IKDF..htp..	0	1	1	1
+11987	PF12154	HCMVantigenic_N		Glycoprotein B N-terminal antigenic domain of HCMV	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2260 (release 23.0)	Family	This domain is found in viruses, and is approximately 40 amino acids in length. The domain is found in association with Pfam:PF00606. There are two conserved sequence motifs: SVS and TSS. This family is the amino-terminal antigenic domain of glycoprotein B of human cytomegalovirus.	25.00	25.00	25.40	35.10	17.70	16.50	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-7.85	0.72	-4.05	3	111	2009-11-24 12:46:55	2009-07-17 10:42:19	3	2	5	1	0	89	0	36.30	76	11.90	CHANGED	HHSSHTosAA+SQSGSVS.QHVTSSQTVSHcsNETIY	.HpuSHTopsspuQotSVSSQ+VTSSEAVSHRANETIY.	0	0	0	0
+11988	PF12155	NADHdh-2_N		NADH dehydrogenase subunit 2 N-terminal	Assefa S, Coggill PC, Bateman A	anon	PFAM-B_2270 (release 23.0)	Family	This domain is found in eukaryotes, and is approximately 90 amino acids in length. It is found associated with Pfam:PF00361. All members are annotated as being NADH dehydrogenase subunit 2, and this region is the N-terminus.	25.00	25.00	26.10	26.10	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.08	0.72	-3.81	2	221	2009-07-17 10:13:53	2009-07-17 11:13:53	3	1	205	0	0	181	0	85.30	93	47.06	CHANGED	MELTLGLIILIVLhYGLKAPTLRLAhlhhGhl....LLhtspLLshTQAIKMLVhLSGLAlLCMLDHphSaRSSSLLILLVILGNLLL	MELTLGLIILIVLTYGLKAPTLRLAMLLAGA......V.....G.AAGLL.AEPHLLCWTQAIKMLVMLSGLAILCMLDHRTSHRSSSLLILLVILGNLLL	0	0	0	0
+11989	PF12156	ATPase-cat_bd		Putative metal-binding domain of cation transport ATPase	Assefa S	anon	PFAM-B_2287 (release 23.0)	Family	This domain is found in bacteria, and is approximately 90 amino acids in length. It is found associated with Pfam:PF00403, Pfam:PF00122, Pfam:PF00702. The cysteine-rich nature and composition suggest this might be a cation-binding domain; most members are annotated as being cation transport ATPases.	27.00	27.00	27.30	27.00	26.80	26.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.55	0.72	-3.45	88	725	2012-10-03 05:12:49	2009-07-17 13:04:01	3	7	717	0	192	664	62	83.30	30	10.60	CHANGED	tsCaHCGtsl.s..tstphpsplpGpp..........+thCCsGCpuVspsIhcsGLssYYchRspsutpspt......tp.hp...phphaDps..-lpppFVppp..ssts	.......pCaHCs.sh......tp..t.hphchtGpt..........+.hCCsGCpuVhphlh-u.GLssYYctcsssuhp..stt....h.pp..hp....phthhD....pl.tpalp.t.t..tt.........................	0	60	126	165
+11990	PF12157	DUF3591		Protein of unknown function (DUF3591)	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2298 (release 23.0)	Family	This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.	25.00	25.00	37.20	25.90	16.40	24.30	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.52	0.70	-6.09	20	386	2009-07-17 12:30:32	2009-07-17 13:30:32	3	36	271	0	294	397	1	387.00	32	30.51	CHANGED	FNI...SNDctY-hLKcsapsKVRuTluslslEHShPAh+LQhPaYKlcLs+p-hRuFHRPshshp.......Pssphs..Fs+lKhpK+K+c+......uKslpElFp..sopDLohsD.susllLhEYSEEhPhhLSNFGMuoKlINYYR+pstcDssRPKhc..lGETplLtspD+SPFh.FGpV-PGchVPTLaNNMhRAPlFKHcscsTDFLllRSos...sssuscaYLRsIsplFsVGQpaPs.sEVPGPHSR+VTshsKNRL+MllYRllp....+stp++.....lplcsls+HF.PDps-hQNRQ+LK....EFhcY.pRcu..t..pGaWclKps-slPsE.cslRsh.....loPE-lChl-SMpsGtppL.cDuGYspssch............tc-tct............thslEppLAPWssT+NFlsAopGKAMLplHGtGDPTGpGEGFSFl+T.SMKGGFh.psscsspspstpshstpch.p.puuH.YNVupQQ+hY...--EIc+lWptQppSL	....................................................................aNl...SNDphY..h..pp........t...l....+...s...shu.s....lpHShPAlcLp.Paa.s.chs..chRpFHRP.hphh....................st.t.h......h.thhc+.Kt.p.........................................upsstphFh....pspD.LohpD..usllLhEYsEEtP.lhsphGMus+lhNY.........Y...........+...............+c.s.s..cD.............s........s.....h..s.chc...............h..GEs.hh..ht..........s...SPF..hG...p...lcPGph..l.......slpNshaR.A...........Pla................H................c...............p.....TD..FLllRopp......................................taa...lRpls.....pla.slGQph......P...hEVPuP.pS++ssshh+shL..ph.hhYRlhh...........ps..p.pc..............lphp-lpct..F...Ps..p...s..-.p.Rp+LK................hhpa.....p+..s.s......t..........pshWhl+.s..s....plPsE.-plRsh...lsPEp..........sChh.SM.suppcL.cDsGasppt..h............................................pp...ttpp......................................ths.E.phAPWssT+sFlt.....Ah...p...u..........K....s...h...LplpG.uDPT.G.p..G..pG..FSal+h.s.Kss........t...t..tp.....p......................t.............t........l...ss..pchc.tthp..sstp..pha...--pIp+l.phph.s......................................................................................	0	118	175	242
+11991	PF12158	DUF3592		Protein of unknown function (DUF3592)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2016 (release 23.0)	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in  bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.	29.00	29.00	29.00	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-11.43	0.71	-4.41	88	745	2009-07-17 13:18:40	2009-07-17 14:18:40	3	7	584	0	211	607	46	147.30	21	83.87	CHANGED	hhhhhhh......shhhhshuhhhhhhshhhh.......................................hth.psh................................................................................hpspGplhshp.....................t.tptppsstapsh.lpaphs......sG..........p.......php....atps.......ssp.st...........ht.....hGp.pVsVh.........YsPssPpp..................uhlp..............................................................................................h...........thashshlhhh.........................................................................................................................................................................................................................................................................Gh........hhh.....hsGlhhhht	.....................................................hh.......hhhhh..sl.G...lh..l.llhu.shhhhtp.........................................hphscss................................................................................hcspG.hl.l.css................pp.pp.ps.s.....p.ss.sah..P....s..ltapss......ss.............p.....plt...........asss...........hsushhp.........................................s......tGc.pVs.VaYsPscPpp..................Ahls.....................................................................................................................psh....h.............htashhslhhh..............................................................................................................................................................................................................................................................................................................Gh..........lhh...hhGh.....hh..............................................................................................................................................................................................................................................................................................................	0	73	134	179
+11992	PF12159	DUF3593		Protein of unknown function (DUF3593)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2028 (release 23.0)	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in  bacteria and eukaryotes. Proteins in this family are typically between 98 and 228 amino acids in length. There is a conserved LHG sequence motif.	25.00	25.00	43.70	43.70	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.10	0.72	-4.20	34	137	2009-07-17 13:37:51	2009-07-17 14:37:51	3	4	116	0	75	140	115	91.60	48	58.03	CHANGED	hs.ssLFuLSLlPYLsFLaaL....p+spp.hPpLslhGFthTLlFVulTIssulhApphaG.spLusVDhLHGuAEuFLTLSNhllllGh..hpthpptp	......h..ssLFAlSLhPYLuFLaaL.....s+opp..hPpLslhGFahlLlFVusTIsAuIhAphtYG.psLusVDaLHGuAEuhLTLoNlllVLGhppultp.h.....................	0	24	48	68
+11993	PF12160	Fibrinogen_aC		Fibrinogen alpha C domain	Mistry J, Gavin OL	anon	pdb_2jor	Domain	This domain family is found in eukaryotes, and is approximately 70 amino acids in length, and the family is found in association with Pfam:PF08702. This domain is the C terminal domain of fibrinogen in mammals. The domain lies in the C terminal half of the alpha C region in these proteins. The function of the domain is that of intramolecular and intermolecular interactions to form fibrin.	20.50	20.50	22.10	20.90	20.20	20.00	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.46	0.72	-4.51	12	67	2009-07-17 15:11:56	2009-07-17 16:11:56	3	4	38	2	24	74	0	68.70	47	10.34	CHANGED	usEKV..TSu...uToTT++SCSKTlTKTVl.GPDG++EslKEVlsS-DGSDCu..cs.cls.....hsHsF...pGuLD-hp	...........upEKVTSu...uToTTR+SCSKTlTKTVl.GPDG++EVsKEVlsS-DGSDCs..-sh....-Ls.........hhcsF...tGshDth......................	0	1	2	8
+11994	PF12161	HsdM_N		HsdM N-terminal domain	Bateman A, Assefa S, Coggill P	anon	PFAM-B_2036 (release 23.0)	Domain	This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with Pfam:PF02384. Mutations in this region of EcoKI methyltransferase Swiss:P08957 abolish the normally strong preference of this system for methylating hemimethylated substrate [1].  The structure of this domain has been shown to be all alpha-helical.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.20	0.71	-3.74	142	4604	2009-07-17 15:36:28	2009-07-17 16:36:28	3	25	2890	12	944	3684	555	134.60	20	25.85	CHANGED	lpstlWshA.-hLRss..h...ssscY...tchlLsllFl+hls-hhptp....ppph................................................hh...t............hh.......ss............phpa...sp............lh.p.....................ss......ltptlpp.............hhptlppp........................lpslh..p...ph.t.t...........psphLtpllpth	...............................................ppplWphs.-hLRus.....h.sssca...pphllsllFlKhls-phppt...........hpch..................................................................................................ht.th.t.........................ah..l......st...................phpa.......ps.....................htpp......................................ttps......lhphlsp................hhptlcpt....s.............................s.........hculh..c...ph.p.....t.t..........tps..phLtpllph.............................................................................................................................................	0	338	667	826
+11995	PF12162	STAT1_TAZ2bind		STAT1 TAZ2 binding domain	Mistry J, Gavin OL	anon	pdb_2ka6	Domain	This domain family is found in eukaryotes, and is approximately 20 amino acids in length, and the family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. This domain is the C terminal domain of STAT1. This domain binds selectively to the TAZ2 domain of CRB (CREB-binding protein). In this process it becomes a transcriptional activator and can initiate transcription of certain genes.	21.60	21.60	24.80	28.00	19.40	19.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.35	0.72	-6.82	0.72	-4.48	8	87	2009-07-17 15:38:57	2009-07-17 16:38:57	3	8	48	1	30	65	0	24.20	65	3.35	CHANGED	SRLQ..-NhhPMSPD-acELcRhVu	..SRLQoTDNLLPMSPEEFDElSRhVG........	0	5	7	12
+11996	PF12163	HobA		DNA replication regulator	Mistry J, Gavin OL	anon	pdb_2uvp	Domain	This family of proteins is found exclusively in epsilon-proteobacteria. Proteins in this family are approximately 180 amino acids in length. The structure of HobA is a modified Rossmann fold consisting of a five-stranded parallel beta-sheet (beta1-5) flanked on one side by alpha-2, alpha-3 and alpha-6 helices and alpha-4 and alpha-5 on the other. The alpha-1 helix is extended away from and has minimal interaction with the globular part of the protein. Four monomers interact to form a tetrameric molecule. Four calcium atoms bind to the tetramer and these binding sites may have functional relevance. The function of HobA is to regulate DNA replication and its does this by binding to DNA-A, but the exact mechanism of how this regulation occurs is purely speculative	20.20	20.20	20.80	79.20	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.12	0.71	-4.99	15	195	2009-07-17 15:52:56	2009-07-17 16:52:56	3	1	194	6	22	95	3	176.60	56	99.59	CHANGED	Mp-FlpWoLEsIRc-..puhhu....WhEE+RhEWsPLlAspLcaLL-.GtohIVlTD-cRcWFpsYhlspINpsp.psRP.hLPhhsL+ulas.hcslpss..EsIsLlpDMLsIuFsNsYhaaYIGK.usct+upIAKs+-sSahWlFDEphQNSFhLsSpD-tLDhKLLpLa+LF-cSLsAsLFu+VsL	..................MsDFLoaTLEsIRss..Gs.FMA.....WLEpRRlEWAPLhAuRL+aLLE.G+TFlLhsDEpRuWaEEYhLpNIN.o+.ssRP.hLPFVS.LsSLhc..++.lpsp...E..DIALLsDhL-ISFPNGalaFYIGp.uoDs+ShIAKS+DDShLWLFDEQ.LQDSFYLsS+Dc.cLDlKLIoLY+LFDsSLDAlLFuKVpL....	1	5	18	22
+11997	PF12164	SporV_AA	SporV_proteinAA;	Stage V sporulation protein AA	Mistry J, Gavin OL	anon	pdb_3g74	Domain	This domain family is found in bacteria - primarily Firmicutes, and is approximately 90 amino acids in length. There is a single completely conserved residue G that may be functionally important. Most annotation associated with this domain suggests that it is involved in the fifth stage of sporulation, however there is little publication to back this up.	25.00	25.00	28.10	27.70	24.10	23.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.96	0.72	-4.00	17	224	2009-07-17 15:54:56	2009-07-17 16:54:56	3	1	222	8	32	178	4	92.40	35	44.56	CHANGED	MppplYl+h++clpls.ppplpLtDlApltusp.slhp+Lpshslh+l...opcc+phhVlslhclIptI+pp.hPsl-lQslGtspsIVElphpK+ps	......ppslYl+hRpRlcVp.shcVpLGDlAQltuss.slhcpLpsh....hlY+l................sscD+s..+lVI.DlhKlIchIp....pp.hsplplp..hlGsupTlVElhhcK+ps.................	0	9	22	24
+11998	PF12165	DUF3594		Domain of unknown function (DUF3594)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2040 (release 23.0)	Family	This presumed domain is functionally uncharacterised.This domain family is found in  eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00628.	21.00	21.00	22.10	21.20	20.60	20.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.94	0.71	-4.54	8	251	2009-07-17 16:40:26	2009-07-17 17:40:26	3	8	37	0	129	263	0	126.50	65	52.68	CHANGED	RTVE-lF+DFKuRRuGIl+ALTsDVE-FYpQCDPEKENLCLYGaPNEsWEVNLPAEEVPPELPEPALGINFARDGMpEKDWLSLVAVHSDuWLLSVAFYFGARFuFs+sDRKRLFsMINDLPTVFEVVTG.AcKQsK	.........................RTVE-lF+DF+uRRuGll+ALTsDVEcFYp...CDP.E.K.ENLCLYGhPsE.sWEVsLPAEEV.PPELPEPA.LGINFARDGMpcKDWLSLVAVHSDuWLLuVAFYFGAR........hs+s-R.....KRLFsMIN-LPTlFEVVTGt.pt..........................	0	20	83	110
+11999	PF12166	DUF3595		Protein of unknown function (DUF3595)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2166 (release 23.0)	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in  eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.	26.90	26.90	27.10	28.80	24.60	26.80	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.30	0.70	-5.66	24	389	2009-07-17 16:45:50	2009-07-17 17:45:50	3	9	130	0	250	313	3	308.60	33	22.84	CHANGED	ptlPFLaELRslhDWshocToLslhpWhplEDIaspla.hpsthps.cph.t.pGpphshhsKhhhGshhlhhllhllahPLhlaSshsss.spsN.lhssshplslssh........shaph........ssphphhsssthtpl.....tt.htppptthp........hhtshstpslptsplsspSsshWslSssuhppllppLpssst.....slphphsap...hpRshsttsshtths..p...............hths.stptsLtphLps..............................sstsl.lsphaspalps.s...sstsp.hpt..............ttpshhshshthhpsptst...............sstaWsls.tpss...t....................t.sttsppsslhhhlhs-cssss.h..uhlsuh..GIlulYsohlLslG+hlR.uhhsstspplhhpchsps-cllplCpsIhlsR......p...ss-htLEptLahcLlplhRSPEpllchTtst	............................................hhlPFLhELRslhDWshos.Tolsl.pWhphEDlaspla...hc..s..ht...pp.......t............h...u.........h.K.hh.Gh.hhhhllhhlhhPlhhhu.hpss..s..N.shpss..hplpltsh.................shath.............t.pl...hp.p.hpph.................h........shp...................altt....a..t.p.-l.h........hphpspSsthWtlssssptphhppL.pst.................th.hhhpap...hpRph...s...tt...h..ht..........................h....t........ttt.lhp.hltt.....................................................ttshhl.phhP.alps.s...tspsp.hp.........................t.thh.shph.....h.tt.........................................taW.hp............................................tttt.l..hhhhs-cs.ss.h....shlssh...GIhuLYhoh..VLslu+.hlR.thhst.shpIha--LPssDcllplCp-IalsR......p...tt-htlEctLahcLlhlaRSPchhlchTp................................................	0	95	131	192
+12000	PF12167	DUF3596		Domain of unknown function (DUF3596)	Assefa S, Coggill P, Bateman A	anon	PFAM-B_2234 (release 23.0)	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00589. It is likely that this domain acts to bind DNA.	21.90	21.90	22.40	22.50	21.20	21.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.93	0.72	-4.44	60	686	2012-10-03 08:51:45	2009-07-17 17:52:51	3	6	484	0	96	500	13	62.00	47	16.03	CHANGED	hsulcsR.....ssp.....LplsFpYpGhRsREph....s..L.sTstNhKpApplhspIptcIphGsFs...YucaF....PpSp	...............PsGVEs+.....Gup.....LRIhF...hY+G.....tRsREsL......G..lsD..Tsc......N......RKhA.G.c.LR.splsatIc.....tGsF-...YucpFPsS..............	0	16	51	80
+12001	PF12168	DNA_pol3_tau_4		DNA polymerase III subunits tau domain IV DnaB-binding	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2296 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.	25.00	25.00	29.50	28.00	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.21	0.72	-3.58	16	635	2009-07-20 12:56:15	2009-07-20 13:56:15	3	5	631	0	50	312	0	82.10	63	13.02	CHANGED	Rsthp+p.........ptsossKKucsAuup+ht...sSsLERlApl....oppspsp..uspssE.ppstccEsYRW+sopss-.ppspsl.sTPpsLK	.........RpQLQRs............QGuTKsKKSEPAAAoRARP..............VNNuALERLASV..............T-RVQARP.....sPSALE..cAPsKKEAYRWKATTPVh....QpKEVV.ATPKALK..........	0	2	12	31
+12002	PF12169	DNA_pol3_gamma3		DNA polymerase III subunits gamma and tau domain III	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2296 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.51	0.71	-4.44	52	3954	2009-07-20 12:56:32	2009-07-20 13:56:32	3	19	3800	30	939	3190	2267	136.90	21	21.86	CHANGED	losspV+sMLGLuD+uplhcLh-slhcGDsssuLsthcstYstGADPhslLpsLh-hhHhlohhchss.s.sps.t...hspsEpp+htshAppLuhtsLsRhWQhLLKGhpElppAscPhtAAEMsLlRLsasusLPsPc-hl+pl	..........................phptlpphLGslspshlhpllcAl.hp......s-s..t...pshshlpplh.spG.h-hpphlp-L.......lph.l.+clhl..hph.......s....P....s.ht..................t..s.ttp.p...h.p.ph........A...pp...l...s...s.ppltthh.p.h...l..h...pu.p.p...-lp.h........u..s.s......+hhlEhsllRhht...........................................................................................	1	304	617	796
+12003	PF12170	DNA_pol3_tau_5		DNA polymerase III tau subunit V interacting with alpha	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2296 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau. The extreme C-terminal region of this domain 5 is the part which interacts with the alpha subunit of the DNA polymerase III holoenzyme.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.67	0.71	-4.25	5	839	2009-07-20 13:12:31	2009-07-20 14:12:31	3	7	835	1	114	517	50	140.40	57	22.10	CHANGED	KALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVALNAWKEESDNAVCLHLRSSQRHLNNRGAQQKLAEALSsLKGSTVELTIVEDDNPAVRTPLEWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESI	.......................................................+ALEHEKTPELuAKLAsE.Al...ER...D.s.WAApVupLuLP..KLVEQlAL.N.A.a.K.Ec..s.s.s.s..l.s.LH..LRSoQRHL.N.spuA.QQcLucALSpL..pGssVE..LTI.lED.DNP.As.+TP.LEW.RQAIYEEKLAQ.ARc.SIIADsNIQTLRRFFDAELDEESI......	1	17	44	81
+12004	PF12171	zf-C2H2_jaz		Zinc-finger double-stranded RNA-binding	Assefa S, Bateman A, Coggill P	anon	PFAM-B_2302 (release 23.0)	Family	This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localise in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localisation.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.24	0.72	-3.71	140	2095	2012-10-03 11:22:52	2009-07-21 10:15:49	3	234	343	2	1311	3181	32	26.70	31	6.11	CHANGED	paaChhCs.+hFpsppsh..psHhpo..KpHK	.....aaCthCs..+tFpsppph..psHhpo.....+pHp......	0	368	611	979
+12005	PF12172	DUF35_N		Rubredoxin-like zinc ribbon domain (DUF35_N)	Bashton M, Bateman A, Krishna SS	anon	Pfam-B_1390 (release 4.2)	Domain	This domain has no known function and is found in conserved hypothetical archaeal and bacterial proteins.  The domain is duplicated in Swiss:O53566.  The structure of a DUF35 representative reveals two long N-terminal helices followed by a rubredoxin-like zinc ribbon domain represented in this family and a C-terminal OB fold domain. Zinc is chelated by the four conserved cysteines in the alignment.	23.20	23.20	23.20	23.20	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.06	0.72	-3.94	158	1253	2009-07-21 15:56:27	2009-07-21 16:56:27	3	17	452	2	560	1184	271	36.80	28	19.70	CHANGED	hpustcscLhhp+CssCGph....h.aPPc.shC..spC.t.ut...shp	............tthtpscLhhp+C..ssCGph....haPP+.shC......PpC.t.ut.p..............	0	123	340	478
+12006	PF12173	BacteriocIIc_cy		Bacteriocin class IIc cyclic gassericin A-like	Coggill P	anon	PfamB_170026 (release 23.0), manual	Family	This class of bacteriocins was previously described as class V. The members include gassericin A, acidocin B and butyrovibriocin AR10, all of which are hydrophobic cyclical structures [1]. The N- and C-termini are covalently linked, and the circular molecule is resistant to several proteases and peptidases [2]. The immunity protein that protects Lactobacillus gasseri from the toxic effects of its bacteriocin, gassericin A, has been identified. It is found to be a small positively-charged hydrophobic peptide of 53 amino acids containing a putative transmembrane segment [3] - a structure unlike that of the more common immunity proteins as found in Pfam:PF08951.	20.40	20.40	91.60	91.40	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.07	0.72	-3.95	3	5	2009-07-23 10:40:23	2009-07-23 11:40:23	3	1	5	0	0	6	1	89.00	48	98.02	CHANGED	MVTKYGRNLGLsKVELFAIWAVLVVALLLsTANIYWIADQFGIHLATGTARKLLDAVASGASLGTAFAAILGVTLPAWALAAAGALGATAA	............hs.....huhNhsLsKIEpFsIaAlLV.VALLlssuNIYWIADKFGIHLAPGWYQDlVDaVSAGGSLuTAFAlIlGVTLPAWIlsAAuAFGAsSA	0	0	0	0
+12007	PF12174	RST		RCD1-SRO-TAF4 (RST) plant domain	Overmyer K, Coggill P	anon	Pfam-B_8550 (release 23.0)	Domain	This domain is found in plant RCD1, SRO and TAF4 proteins, hence its name of RST. It is required for interaction with multiple plant transcription factors. Radical-Induced Cell Death1 (RCD1) is an important regulator of stress and hormonal and developmental responses in Arabidopsis thaliana, as is its closest homologue, SRO1 - Similar To RCD-One1. TBP-Associated Factor 4 (TAF4) and TAF4-b are components of the transcription initiation factor complex TFIID.	21.20	21.20	21.20	25.00	21.10	20.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.01	0.72	-4.18	16	135	2009-11-10 14:39:24	2009-07-24 10:38:49	3	7	24	0	80	130	0	69.30	31	11.44	CHANGED	scsPp...SPahPFshLhsslspplspsch.llpppYpch+cp+IoRp-hl+plRpIVG.DpLLtpslpplppp	.................t..hPp...oPhhs..FshLhshlppplspsc...hphlpphYpch+.....cp+IoRcchl+plRtIVG.DclLhpslpplp.......	0	10	44	65
+12008	PF12175	WSS_VP		White spot syndrome virus structural envelope protein VP	Mistry J, Gavin OL	lg7	pdb_2edm	Domain	This family of proteins is found in viruses. Proteins in this family are approximately 210 amino acids in length. There is a conserved NNT sequence motif.  These proteins are structural envelope proteins in viruses. This is the beta barrel C terminal domain. There is a protruding N terminal domain which completes the proteins. Three of four envelope proteins in white spot syndrome virus share sequence homology with each other and are present in this family - VP24, VP26 and VP28. VP19 is the other major envelope protein but shares no sequence homology with the other proteins. These proteins are essential for entry into cells of the crustacean host.	20.40	20.40	23.30	143.10	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.30	0.70	-5.24	3	37	2009-07-27 13:17:05	2009-07-27 14:17:05	3	1	2	13	0	26	0	186.50	49	100.00	CHANGED	M-hu.hhuVsuAILAILol.IlVlIVIhVhpIslNK+l-p+s+slhsNhDEhlRlPIsucA+usaF+hs-sSasTcsLGKVtl+.NGpSDu-MK-ccADLVIToVpG..sRTLsVssGpspohEhThKlaNNTuRDIsIsulolsPsl.......NssS+sFsuSKslpSFoPsllccDcluTFVsGATF-AsIssTssupLlsMhhcss.s..clccK	.Mch....uVsuAILAhhsl.IhVhIsIhhhp.slsKpl-p+scsl.sNhDE.lRlPlsucstusaF+hs-sSasocsLGKltl+.NGpSDupMK-ccADLVITsVpG...RsLpVssGpshohEhThKVaNNTuRcIsIsuhphsPpl........ssS+sFsuSpsspSFoPsslccDcluTFVsGsTFsAsIssTssup.h..hhp......thtp..................	0	0	0	0
+12009	PF12176	MtaB		Methanol-cobalamin methyltransferase B subunit	Mistry J, Gavin OL	lg7	pdb_2i2x	Domain	This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 460 amino acids in length. MtaB folds as a TIM barrel and contains a novel zinc-binding motif. Zinc(II) lies at the bottom of a funnel formed at the C-terminal beta-barrel end and ligates to two cysteinyl sulfurs (Cys-220 and Cys-269) and one carboxylate oxygen (Glu-164). The function of this protein is to catalyse the cleavage of the C O bond in methanol by an SN2 mechanism. It complexes with MtaA and MtaC to perform this function.	25.00	25.00	184.40	28.20	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	461	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.49	0.70	-6.07	9	44	2009-07-27 13:17:44	2009-07-27 14:17:44	3	2	29	8	32	42	3	442.20	49	99.39	CHANGED	ulK+aTcMAYsSADDMlFGpuhaPVKsGhslcIGAGhshPElNhA..PRstutpSh-cLl+EYc+IssDshpRhlplGhPulllEsEHVpQMopsP-WGuclA+sQ+shME-aHDcYGlKsuLRpTluDIREsc-hhtLR.GDphsshhEuFEpCApNGADhLSlEShGGKEVaDYuIlRNDlsGlLauIGlLGolDMEalWscIucIAKKpssluuGDTDCAQANTAMFlAGGLhsKNluHTlAslARAISAsRSLVAYEsGAlGPGKDCGYENsIlKAIuGVPIutEGKoSTCAHSDlMGNLshpsCDlWSNESVEY+tEFGGTTstsWsEoLuYDCALMNTAhphGppKsL..RDhhhlSD+YRDPQuYlLAYDNAY+lGcAIVK-GcDIYLRuKsAAlcsspIlcEGh.cG+LcLoRFE+cuLsssppslEuLsDDpDcFhp-ClpKYtpcVKsF+PEsYs	..h.hp+aTcMAYssuD-MlFGpuKpPVKsGhGhpIGuGhshPElNhA..P.t..tutpSh-KllpEYccIspslhpRhlplGhPulllEpEHVtQhopNPcWGu-lspsp+slME-YHDcYGlKsuLRpT.uDlREpcch.pLR.G-passhhEuFEtCApsGADhLSlEShGGKEVaDaullRsDhtulLauIGVLGohDMEhlWp-IscIAcKssslsuGDTDCuQANTAMFlAGGLhcKsluHThAslARAIuAsRSLVAaEsGAhGPsKDCGYENsIlKAIsGlPIutEGKousCAHSDlhGNLshtsCDlWSNESVEa+tEhGGsTspsWhEsLuYDCuLMNsAlppGppK.L..RDhhshSD+YRDPQuYlLuYDNAY+IGpAIl+sGcshYLRuKsAAlc.shpllc-us.sG+LpLoRFEpcsLspsppslEuLsDDp-cFhs-slp+YppcVchFcPpsYs..........	0	8	24	27
+12010	PF12177	Proho_convert		Prohormone convertase enzyme	Mistry J, Gavin OL	lg7	pdb_2ke3	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF01483, Pfam:PF00082. There are two completely conserved residues (Y and D) that may be functionally important. This protein is the C terminal domain of a prohormone convertase enzyme which targets hormones in dense core secretory granules. This C terminal tail domain is the domain responsible for targeting these dense core secretory granules. The domain adopts an alpha helical structure. 	25.00	25.00	28.20	59.10	19.90	18.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.96	0.72	-4.37	3	51	2009-07-27 13:18:22	2009-07-27 14:18:22	3	1	38	2	24	52	0	41.00	76	5.49	CHANGED	phKDsEDSLYNDYlDsFYNsKPYKHRDDRLLQALl-Ils-D	..QLKDSEDSLYsDYVDVFYNTKPYKHRDDRLLQALVDILsEE..	0	1	3	10
+12011	PF12178	INCENP_N		Chromosome passenger complex (CPC) protein INCENP N terminal	Mistry J, Gavin OL	lg7	pdb_2qfa	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.	20.60	20.60	21.90	20.80	18.30	18.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.57	0.72	-7.65	0.72	-4.41	7	80	2009-07-27 13:21:03	2009-07-27 14:21:03	3	2	45	1	33	72	0	37.40	46	4.94	CHANGED	spuhtpLhplhspKlt-FlsplDshchlWL-EIppEAt	..t.Gsh+LLElC-pKLhEFlsshDNKDlVWLEEIpEEAt..	1	2	6	17
+12012	PF12179	IKKbetaNEMObind		I-kappa-kinase-beta NEMO binding domain	Mistry J, Gavin OL	lg7	pdb_3brt	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.	25.00	25.00	25.90	25.70	24.50	18.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.65	0.72	-4.13	9	110	2009-07-27 13:23:03	2009-07-27 14:23:03	3	3	39	6	48	84	0	37.60	47	5.40	CHANGED	SE-LltEuhsLCspLEoslp-sh+EQ-pSlhuLDWSWL	.....tplltEshshhupLpohlp-....sscEQspShMsLDWSWL....	0	2	5	14
+12013	PF12180	EABR		TSG101 and ALIX binding domain of CEP55	Mistry J, Gavin OL	lg7	pdb_3e1r	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.	25.00	25.00	25.00	25.00	19.50	23.70	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.68	0.72	-4.60	6	110	2009-07-27 13:23:54	2009-07-27 14:23:54	3	1	43	2	55	98	0	34.90	50	8.56	CHANGED	cppl+cs.-hNppW.pYDppREsYV+uLhs+lKEL	...cpplpc.s.-hNtpW.pYDtpR-tYV+GLhAplhEh....	0	4	8	21
+12014	PF12181	MogR_DNAbind		DNA binding domain of the motility gene repressor (MogR)	Mistry J, Gavin OL	lg7	pdb_3fdq	Domain	This domain family is found in bacteria, and is approximately 150 amino acids in length. MogR is involved in repression of transcription of the flagellar gene in Listeria bacteria. This allows a phenotypical switch from an extracellular bacterium to an intracellular pathogen. MogR binds AT rich flagellar gene promoter regions upstream of the flagellar gene. These regions follow the pattern 5'-TTTTNNNNNAAAA-3'. This domain is the DNA binding domain of MogR.	25.00	25.00	83.10	82.90	21.60	20.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.88	0.71	-4.43	4	125	2009-07-27 13:24:16	2009-07-27 14:24:16	3	1	120	2	5	94	0	143.50	71	47.21	CHANGED	LLQNMSNsKpNDhpLEu.EFKKIEKQFQVcYEELlDLYNRMVLFQIDIEKpGGMcsYEKSsITWLKSELELLYtVYQFsQRHsLNIhNISKYlSKpELNLF.KTESQLQNTYYKLKKpEIPFENIcKQKPGRKRKYssVKET.sEhKpE	.LLQpMSNNKhNDhpLEs.EhKKIEKpFpVcYEELlDLYNRMVLFQIDIEKHGGhRAYEKSsITWLKSELELLYEVYQFsQRHGLNIlNISKYVSKNELNLFPKTESQLQNTYYKLKKcEIPFENIEKQKPGRKRKYhPVKETlVphKpE.............	0	1	3	3
+12015	PF12182	DUF3642	Lipoprotein;	Bacterial lipoprotein	Mistry J, Gavin OL	lg7	pdb_3ge2	Domain	This domain family is found in bacteria, and is approximately 60 amino acids in length. There is a single completely conserved Y residue that may be functionally important. This domain is from a bacterial lipoprotein, a major virulence factor in Gram negative bacteria.	22.70	22.70	23.90	23.00	22.30	19.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.60	0.72	-3.55	10	315	2012-10-03 08:47:39	2009-07-27 14:26:22	3	1	274	1	16	161	0	78.20	62	47.50	CHANGED	spsoslDGoYsusD.-s....DQlTLploGsoGThTclEsDG-cElcQVss-usNQ+LII...GD.DsKpYphsGNQLsl-DhDc-s	......AQPT-IDGTYTGQD.DG....D+ITLVVTGTTGTWTELESDGDQcVKQVTFDuANQRMII.....GD.D..VKIYTVNGNQllVDDMDRDP...................	1	1	3	7
+12016	PF12183	NotI		Restriction endonuclease NotI	Mistry J, Gavin OL	lg7	pdb_3bvq	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 270 and 341 amino acids in length. There is a conserved CPF sequence motif. The type IIP restriction enzyme, NotI, is a homodimer that recognizes the 8 bp DNA sequence 5'-GC/GGCCGC-3' and cleaves both strands of DNA to create 5', 4 base cohesive overhangs.	25.00	25.00	62.30	62.10	19.30	18.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.90	0.70	-5.30	13	53	2012-10-11 20:44:46	2009-07-27 14:38:24	3	1	49	4	17	50	1	226.60	26	80.31	CHANGED	ElFGaps..ss.u.hsspppupct.CPFh.spps.KsoKspst.shGVCSl...h..........scsupslIlCPhR.atpchpIhs-suchhhs...................h.tuhhhthtpththssshGcs...sGsEh.ls...t.....lDalLsphss....G+lhDaVulElQslshoGsh+shhpph.............hppspuphuhsW............osstKRllPQLhaKGsllc+.....hstKhshllpcshathlsc.h................lspht.hpsushsa.hlh-hc.sss....t.thpL	........................EhhG.th..s..t..h..hthhtp..CPFh.sppC.K.spKsps....GsCol.....h...................tpssp.hIlCPhR.hhp....chphhhpshphhhs............................................t+p...sGsElpls......t.sth.lDalLsshss....sclhDaVulElQslspTGss.ts.ppphht...........hppstsphuhs.W............psstKRllsQlhhKsplhcp.....hstKhshllppthathhsp.h................htphp..hpttshsh.hhhshc.stp...............................................................	0	3	7	16
+12018	PF12185	IR1-M		Nup358/RanBP2 E3 ligase domain	Mistry J, Gavin OL	lg7	pdb_1z5s	Domain	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00638, Pfam:PF00641, Pfam:PF00160. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.	25.00	25.00	25.00	25.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.07	0.72	-4.25	4	96	2009-07-27 15:58:16	2009-07-27 16:58:16	3	30	40	4	59	87	0	62.00	51	4.32	CHANGED	Ds.IVaE+cPTsEpcAhAcpLpLPPTFFChhspsD.ospDpscsEDF-otV+KlptcLhspssEt	...-slIVaEtpPTsEpKAhAcpL+LPPTFFChhsts...D..ssE-p..pssEDFpotl+Klptt.h.pspc.t........	0	8	12	29
+12019	PF12186	AcylCoA_dehyd_C		Acyl-CoA dehydrogenase C terminal	Mistry J, Gavin OL	lg7	pdb_2oku	Domain	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF02770, Pfam:PF00441, Pfam:PF02771. There is a conserved ARRL sequence motif. The C terminal domain is an alpha helical domain. The flavin ring of Acyl-CoA dehydrogenase is buried in the crevice between the two alpha helical domains and the beta-sheet domain of one subunit, and the adenosine pyrophosphate moiety is stretched into the subunit junction of a neighbouring subunit, composed of two C terminal domains.	19.80	19.80	20.50	21.20	19.30	19.50	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.37	0.71	-4.22	7	120	2009-07-27 15:59:57	2009-07-27 16:59:57	3	2	119	2	18	101	7	112.90	46	19.94	CHANGED	TsGoYlApIR.EapslsssPEhpsLps+LtcMss+a-AssstVpEspDQELlDFhARRLhEMAAchlhuHLLlQDAsKs.D.FtcSApVYlpYupAEl-KapsFIppFst-DLAh	.............TNGoYlupl+.E.apphss..usE.hpsLhsRlpcMss+aEsssstVK..EspsQE...l...hDFhARRLhEMAAclIMuaLLlpDAo.KusELFuKSApVYlpaAEuEVpKHtsFIcsFcsEDL...........	0	9	16	18
+12020	PF12187	VirArc_Nuclease		Viral/Archaeal nuclease	Mistry J, Gavin OL	lg7	pdb_2w8m	Domain	This family of proteins is found in archaea and viruses. Proteins in this family are typically between 211 and 244 amino acids in length. These proteins are nucleases from fusseloviruses and sulfolobus archaea.	19.70	19.70	19.90	20.90	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.27	0.71	-4.89	4	13	2012-10-11 20:44:46	2009-07-27 17:00:09	3	2	13	2	3	15	1	174.20	44	76.43	CHANGED	sFK.+YWuNps.-sa.lPs.aLGREYLlhGhLhIpLtpW+.KGLlcFDlYl+.TGlGTLTsVINcpYYpsl.DKYDLTlYh+hK....spYaPhlaIDlTGSSWTEEQSccR.....YGEulYAILSsKVpVApph-VhG.RshFIHYsDpEDKLKhIsALpILNLE+QGK...I+h-caEhsAtSpYYlIPlphWKNls-LRV	....................................FKLKYWGspt.-sYlLPs.hLGREYLllGKL.hIpLupW+.KGhl-aDlYl+.oGlGTLT.NsIN.pYYcslpDKYDhTlYl+sK....cpYaP..LlaIDITGSSWTEEQSccR.....YGESlYAILSsKV-VApcas..VhG.RVaFlHYsDsEDKLKsIoALQILNLE+psK...IKhDcFEpsAtSpYYLIPlphWKNlhELR...........	1	1	1	3
+12021	PF12188	STAT2_C	STAT2_Cterm;	Signal transducer and activator of transcription 2 C terminal	Mistry J, Gavin OL	lg7	pdb_2ka4	Domain	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF02865, Pfam:PF00017, Pfam:PF01017, Pfam:PF02864. There is a conserved DLP sequence motif. STATs are involved in transcriptional regulation and are the only regulators known to be modulated by tyrosine phosphorylation. STAT2 forms a trimeric complex with STAT1 and IRF-9 (Interferon Regulatory Factor 9), on activation of the cell by interferon, which is called ISGF3 (Interferon-stimulated gene factor 3). The C terminal domain of STAT2 contains a nuclear export signal (NES) which allows export of STAT2 into the cytoplasm along with any complexed molecules.	20.00	20.00	76.60	75.30	19.70	16.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.65	0.72	-4.17	5	42	2009-07-27 16:00:45	2009-07-27 17:00:45	3	5	23	1	11	33	0	56.00	62	7.09	CHANGED	SQPlPEPDLPcDLQQLNT--M-IFRNslsIE-IMPNGDPLLAGQNo.VDEAYlSppS	......SQslPEPDLPpDLRHLNTE-ME...IFRNs.h+IEEIMPNGDPLLAGQNT.sDEsalsp.S...	1	1	1	1
+12022	PF12189	VirE1		Single-strand DNA-binding protein	Mistry J, Gavin OL	lg7	pdb_3btp	Domain	This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved IELE sequence motif. VirE1 is an acidic chaperone protein which binds to VirE2, a ssDNA binding protein. These proteins are virulence factors of the plant pathogens Agrobacteria. VirE1 competes for the ssDNA binding site of VirE2.	25.00	25.00	26.10	101.90	17.80	16.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.00	0.72	-3.85	4	9	2009-07-27 16:02:35	2009-07-27 17:02:35	3	1	5	1	3	6	0	62.30	61	95.08	CHANGED	MAIIKLpsNKsRsssssEcPpEl.tEEhShsH.ssGFTsLDLcMIELEsFVL+CPLPE-NLAG	MAIIKLpANKNRsssssEcPpcl.hEEhSssa.ssGFTSLDLcMIELEsFVL+CPLPE-NLAG	0	1	3	3
+12023	PF12190	amfpi-1		Fungal protease inhibitor	Mistry J, Gavin OL	lg7	pdb_3bt4	Family	This protein family is found in eukaryotes, and is approximately 50 amino acids in length. These proteins are fungal protease inhibitors.	25.00	25.00	25.20	29.30	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.44	0.72	-3.48	2	9	2009-07-27 16:04:19	2009-07-27 17:04:19	3	1	6	1	2	11	0	85.00	68	91.29	CHANGED	Csht..YGsLVCGosYCcppPChpP.h...C.pso.aRA+HAGKCACCPACVThLGEsAsCKhYSKELGETPSAlC+-PLKClptVCT+ls	.Clhs..YGsLVCGTsYCcpNPChpPshs..C.pso.aRA...pHAGKCACCPACVTLLsEsAsCKhYSKELGETPSAVC+EPLKClptVCTKls.	0	1	2	2
+12024	PF12191	stn_TNFRSF12A		Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain	Mistry J, Gavin OL	lg7	pdb_2eqp	Domain	This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 184 amino acids in length. This is the stn_TNFRSF12A_TNFR domain from the tumour necrosis factor receptor. The function of this domain is unknown.	21.40	21.40	21.40	21.50	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.79	0.71	-4.10	2	45	2009-07-28 09:54:12	2009-07-28 10:54:12	3	2	30	4	23	46	0	108.70	54	87.92	CHANGED	MsP...RsL.phhV.hhhLVL......ppAsupu.CspGpuaStDLsKCM-CusC.sp.+SDFC.sCsuts.t..F.hlWsIhhuAhulhLllsllShhlhhp+CRR+pKFTTPIEETGucus.ul.LIp	..........................L.thLVhshhLsL.tusuG.ppsPGsuPCucGoSWSuDLD.KCMDCuSC.uRP+SDFChGCuAAPPAs..FpLLWPILGGALSLs..lV.LuLLS.GFLVWRRCRRREKFTT.PIEETGGEGCPuVALIQ......................................................................	0	7	7	10
+12025	PF12192	CBP		Fungal calcium binding protein	Mistry J, Gavin OL	lg7	pdb_2jv7	Domain	This domain is found in eukaryotes, and is approximately 60 amino acids in length. There is a single completely conserved residue C that may be functionally important. This is a calcium binding domain from the fungal protein CBP (calcium binding protein). This protein is a virulence factor with unknown virulence mechanisms. CBP complexes as a highly intertwined homodimer. Each monomer is comprised of four alpha helices which adopt the saposin fold, characteristic of a protein family that binds to membranes and lipids.	25.00	25.00	59.60	58.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.86	0.72	-4.02	5	12	2009-07-28 09:54:30	2009-07-28 10:54:30	3	2	11	2	8	14	0	57.20	47	25.99	CHANGED	QPuVscAhs.aNpsVssFpKAouAAuCsWlsCluSLuuoSAACAAAluELGLcPPsDLA	.......tPultcAhspaNpsVssFpcAouAAuCsWlsClpSLuuoSAACAAAluELGLs..hDhA......	0	1	2	5
+12026	PF12193	Sulf_coat_C	Sulf_coatprot_C;	Sulfolobus virus coat protein C terminal	Mistry J, Gavin OL	lg7	pdb_3f2e	Domain	This domain family is found in viruses, and is approximately 70 amino acids in length. It is the C terminal of a coat protein in sulfolobus viruses.	25.00	25.00	38.40	136.40	22.50	17.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.44	0.72	-4.16	3	5	2009-07-28 09:55:13	2009-07-28 10:55:13	3	1	5	1	0	5	0	69.00	86	54.25	CHANGED	VSAVLTQYGITGPNRAIYQGFGLKVARALNRIGSGPALVNMINGLKuYYISAFNANPQVLDAVVNIITG	VSAVLTQYGITGPNRAIYQGFGLKVARALNRIGSGPALVNMINGLKAYYISAFNANPpVLDAVTNIITG	0	0	0	0
+12027	PF12194	Ste5_C	ste5minscaffold;	Protein kinase Fus3-binding	Mistry J, Gavin OL	lg7	pdb_3fze	Domain	This domain family is found in eukaryotes, and is approximately 190 amino acids in length. This domain is the penultimate C terminal domain from the protein ste5 which co-catalyses the phosphorylation of fus3 by ste7. It is involved in the MAPK pathways. This domain is the minimal scaffold domain of ste5. It binds to the mitogen activated protein kinase fus3 before it is phosphorylated.	25.00	25.00	185.80	185.00	22.50	17.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.08	0.71	-4.67	5	22	2009-09-14 13:25:02	2009-07-28 10:55:46	3	2	21	1	12	24	0	192.70	54	22.33	CHANGED	hTSISSILSLKRE+P--LsLlLQIDppKlp.-DshI..lItNoLpALshKFsshphClVDusGhVlshGols+hI.sLsSIus.hc+ssusp+FSPshL+splY..spsIpcNLGIVllSNSuMEpuKSlLFpDY+sFsShGRRRPNELKIKVGYLNsDYSDpIsELVEIuoWsalLEALCYSFuLSFDDDD..DD-Es	h.TTISSILSLKRE+PDsLsIlLQIDFpKLKp-csll..llYNSLKALolKFscLphChVDpsshVlsaGslhctIssl-ulss.LcppsuuppFSPhWLKNoLY..PcsI+cpLGIlslSNSsMEscKSlLF.DY+sFsuhGRRRPNELKIKVGY..LNVDYSDKIsELVEsuSWshlLEoLCYSFuLuFD-DD..DD--.....	0	1	6	12
+12028	PF12195	End_beta_barrel	Endosialidase; Endobetabarrel;	Beta barrel domain of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is approximately 80 amino acids in length.This domain is the beta barrel domain of bacteriophage endosialidase which represents the one of the two sialic acid binding sites of the enzyme. The domain is nested in the beta propeller domain of the endosialidase enzyme. The endosialidase protein complexes to form homotrimeric molecules.	26.50	26.50	28.40	34.90	24.10	26.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.85	0.72	-4.25	3	30	2009-07-28 13:31:40	2009-07-28 14:31:40	3	9	26	18	2	27	19	83.00	73	8.81	CHANGED	SRSLHlTGGITKAANQpsATI+IsDHGLFAGDFVNFSNSAVTGVSGNMTVATVIDKNTFTVTTsNsQsSDlNNAG+sWsFGTS	.........SRSLRlYGGITKAANQQVAYIRITDHGLFAGDFVNFSNSGVTGVTGNMTVTTVIDKNTFTVTTQNT.....QDVDQNNEGRYWSFGTS.......	0	0	0	0
+12029	PF12196	hNIFK_binding		FHA Ki67 binding domain of hNIFK	Mistry J, Gavin OL	lg7	pdb_2aff	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00076. There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.	25.00	25.00	29.00	27.90	20.40	19.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.64	0.72	-8.11	0.72	-4.57	5	73	2009-07-28 13:32:34	2009-07-28 14:32:34	3	2	40	1	31	53	0	39.30	63	14.58	CHANGED	SVsSQDPTPVCTPTFLERRKSQlhEl..sDD-cDDEIVLKLPl	......oVDSQGsTPVCTPTFLERRKSpVA-h..NDDDcDs.EIVFKpP....	0	1	2	9
+12030	PF12197	lci		Bacillus cereus group antimicrobial protein	Mistry J, Gavin OL	lg7	pdb_2b9k	Domain	This domain is found in bacteria, and is approximately 40 amino acids in length. This domain is found in bacillus cereus group bacteria. It is an antimicrobial protein.	20.30	20.30	20.70	20.40	19.90	20.20	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.12	0.72	-4.37	4	37	2009-07-28 13:32:52	2009-07-28 14:32:52	3	1	31	1	9	30	0	38.90	38	34.23	CHANGED	s.hhlpSssGsFANSFspsGsTWYhKGK.hpsspGsWsuaYE..s+	...............pssG.FAssF.t.s....G..hpWYhKG...t.hc..scGpWsGaYE....t....	0	2	4	5
+12031	PF12198	Tuberculin		Theoretical tuberculin protein	Mistry J, Gavin OL	lg7	pdb_2g6r	Domain	This domain family is found in bacteria, and is approximately 30 amino acids in length. This protein is a theoretical model of the tuberculin protein from Mycobacterium tuberculosis.	25.00	25.00	83.90	64.50	18.90	16.30	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.46	0.72	-7.30	0.72	-4.06	2	6	2009-07-28 13:34:07	2009-07-28 14:34:07	3	2	2	0	0	6	0	34.00	77	21.36	CHANGED	ohtplspsuGutS.u+NGsQhRhlAssGPtSuTh	SLASVSSVSGGGSVSRNGNQARFVAPTGPASSTF	0	0	0	0
+12032	PF12199	efb-c		Extracellular fibrinogen binding protein C terminal	Mistry J, Gavin OL	lg7	pdb_2gox	Domain	This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a conserved VLK sequence motif. It is the C terminal domain of bacterial extracellular fibrinogen binding protein. It contains a helical motif involved in complement regulation. This motif binds to complement and changes its conformation to a form which cannot activate downstream components of the complement cascade.	21.40	21.40	21.50	21.80	21.20	19.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-9.08	0.72	-4.12	2	315	2009-07-28 13:34:20	2009-07-28 14:34:20	3	1	161	12	2	47	0	64.70	69	47.90	CHANGED	TshphphppKllpAQphVp.Fc+T+TVusHRKAQ+AVNLlpFpaphcKhhLQcpID.VLK.shl+	..TshphphppKllpAQphVp.Fc+T+TVusHRKAQ+AVNLlpFpashcKhhLQcpID.VLK.shlK.....	1	2	2	2
+12033	PF12200	DUF3597		Domain of unknown function (DUF3597)	Mistry J, Gavin OL	lg7	pdb_2gqb	Domain	This family of proteins is found in bacteria, eukaryotes and viruses.  Proteins in this family are typically between 126 and 281 amino acids in length. The function of this domain is unknown. The structure of this domain has been found to contain five helices with a long flexible loop between helices one and two.	23.50	23.50	23.50	23.70	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.75	0.71	-3.75	24	206	2009-07-28 13:34:35	2009-07-28 14:34:35	3	7	187	1	69	167	11	119.50	50	74.91	CHANGED	IFupIhstIF..........ucutsAsPsusssssssssuss...................suP...ussPsu................ssVDVuslL-thssp.pup+LsW+TSIVDLMKhLslDSSLsuRKELApELGYoGD.psDSAsMNIWLHKQVMpKLAtNGGKlP	...................................................IFspIhstIa.............ucups..A.s.ss...utssss.s...sss.s.sssss.....................uAs......ussPsu............................ssVDVsAlL-shstp...suptL...NW+TSIVDLMKhLGLDSSLptRKELApELGYo.GD..hsDSAoMNlWLHKpVhpKLt-NGGKlP........	0	8	33	51
+12034	PF12201	bcl-2I13		Bcl2-interacting killer, BH3-domain containing	Mistry J, Gavin OL	lg7	pdb_2ipe	Domain	This is a family of pro-apoptotic Bcl-x proteins, B cell leukaemia/lymphoma 2, or BIKs.  BIK proteins rely for their activity upon an intact BH3 domain lying between residues 48 and 80, as in UniProt:Q13323.	25.00	25.00	41.10	40.70	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.01	0.71	-4.76	2	21	2009-07-28 13:35:07	2009-07-28 14:35:07	3	1	19	0	10	21	0	135.00	52	98.40	CHANGED	MSEsR.huRDl.hcTl.a-Ql.pPPsh.Es.uMp-......PhcDhD.hEChEGpstlALRLACIGDEMDlsLRuPRLsQLstlAhHp..LAhhYspT.slRslhRShhcuhTsL+ENIhp.WRs.sPGuWVSs-Qs.htLh.hlhLlh.LLuGuhaL.L	....MSpsRPloRDhhh-TlLaEQl.pP.sh.Es.G.ho-.....tEshsPhc..Dhs.hEChEssDtlALRLACIGDEMDVsLRuPRLAQLstlAMHS..LAhhYsQT.slRsVLRShhcGhTsL+ENIhp.WRs.sstuWVo...........p.s...h.lh.hlhLlh.hh...........................................	0	1	1	2
+12035	PF12202	OSR1_C		Oxidative-stress-responsive kinase 1 C terminal	Mistry J, Gavin OL	lg7	pdb_2v3s	Domain	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00069. There is a single completely conserved residue F that may be functionally important. OSR1 is involved in the signalling cascade which activates Na/K/2Cl cotransporter during osmotic stress. This domain is the C terminal domain of OSR1 which recognises a motif (Arg-Phe-Xaa-Val) on the OSR1-activating protein WNK1.	25.00	25.00	26.60	26.10	23.10	22.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.49	0.72	-4.32	16	453	2009-07-29 08:07:16	2009-07-29 09:07:16	3	6	84	3	231	395	0	35.70	50	2.76	CHANGED	lpLhLRlc-sKKhtt.+.K-NpAIcFpFslt+DssE-VA	.......lpLhLRlcDsKK.tt.+.+-NpuIcFpFslt+.DssE-VA....	0	35	56	140
+12036	PF12203	HDAC4_Gln		Glutamine rich N terminal domain of histone deacetylase 4	Mistry J, Gavin OL	lg7	pdb_2o94	Domain	This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.	25.00	25.00	26.20	26.20	22.70	24.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.60	0.72	-4.05	6	235	2009-07-29 08:07:40	2009-07-29 09:07:40	3	4	46	8	78	202	0	86.40	69	9.97	CHANGED	ssDPslREpQLQQELLLlpQQQQIQKQLLIAEFQKQHEpLTRQHpAQLQEHLK.QQELLAhK+QQELhE+cRKLEQQRQEp........ElE+HRREQQL	........sDPslREpQLQQELLhlpQQQQlQKQLLIAEFQKQHEpLTRQHpAQLQEHl.K................QQ..Eh.........L.A.........hKpQQ.ELL.E..+ppKLEQpRQEQ.........ElE+p+REQpL.........................	0	5	12	36
+12037	PF12204	DUF3598		Domain of unknown function (DUF3598)	Mistry J, Gavin OL	lg7	pdb_2o62	Domain	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 230 and 398 amino acids in length. These proteins are formed entirely from B sheets which form a barrel structure similar to those seen in the lipocalin superfamily.	21.20	21.20	21.30	21.20	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.69	0.70	-5.15	18	117	2009-07-29 08:08:10	2009-07-29 09:08:10	3	3	73	2	52	123	46	228.00	22	76.76	CHANGED	spW-shh.pNLGE...WpGSFTchSPpG...-llpshsSlloLpuhsc.sphl+hslthas............pts.sp-hspcasulu......pphlaFss.GAFSpGshQLuPaucFuuEhGFlpcsRRhRlV.lascsGpLscloLIREahuus....susEpPsLps-p....LLGpWpGcshohhPDh..p.sph..hph.l.......................tsuslpusthha.tspp..spl.hhLPDGsusssPpplph.....cpsFhlElGWLlpssp...hpRllRpYsspGpWhuloLls.p	...............................................................................................................................hh..ph...tt....W.G.ah.hs.tt....p....pph..shhphp..........t..hp.....h.h...............................p........pth...........thhhh.s.Gsh.s.s...s.tht.....t.....................h.hh.....E.hhh..h..pt..s..pRhRh.shh..a........stpG...p.........LpplshlcEppsst..............sstpps.lp...pp.......h.hGpWpGpthohhs.sh.........h...............................................psthpsphh.hh.tt........ph.hhLPsGh.hssP....tplth.....tpsF.lphsWl.pssp...hpRllRsYsspG.hhu.ohhh..t................................................................................	2	11	33	45
+12038	PF12205	GIT1_C		G protein-coupled receptor kinase-interacting protein 1 C term	Mistry J, Gavin OL	lg7	pdb_2jx0	Domain	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF01412, Pfam:PF00023, Pfam:PF08518. GIT1 plays an important role in cell adhesion, motility, cytoskeletal remodeling and membrane trafficking. To perform this function, it localises p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulated by interaction between its paxillin-binding C terminal and the LD motifs of paxillin. The C terminal folds into a four helix bundle.	25.00	25.00	25.20	26.70	22.70	21.40	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.54	0.71	-4.28	5	199	2009-07-29 08:09:01	2009-07-29 09:09:01	3	11	78	1	86	202	0	120.70	62	17.57	CHANGED	-u-sDssLPSTEDVIRKTEQITKNIQELLRAAQEsKH-SFVPCSE+IalAVsEMAuLFPKRPssEsVRsSLRLLsSSAsRLQsECKKAsP.-..tssDhphlTQQVIQCAYDIAKAAKQLVTlTT	...............s....sPsLPSTEDVIpKTEQlTKNIQELLRA...AQ...E.s...K.HD.S.al.P.CSE+IHlAVTEMAuLF.P...K+.P..t..p.-.sVRoS...LRLLsuSAYRLQSEC....+Ksl...Ps-s........usssDhQLl..TQ...QVIQCAYDIAKAAKQLVTITT............................................	0	21	28	49
+12039	PF12206	DUF3599		Domain of unknown function (DUF3599)	Mistry J, Gavin OL	lg7	pdb_3f3b	Domain	This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. This domain is the phage-like element pbsx protein xkdh.	25.00	25.00	37.60	119.80	24.20	22.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.54	0.71	-3.83	7	38	2009-07-29 14:17:48	2009-07-29 15:17:48	3	1	33	1	5	32	0	117.30	49	97.21	CHANGED	MSYpphLs+RCDIYHLtppcsptt.+aGIPucclp..hpYsDTPDlpslsCYFhEKsp....ollQpEPppslhpSaLlHFPhssDIRhpDKslhc..GhsahLppP.+tl+sHHhEVhAlRcpp	.MSYpphLsHRCDIYH.ttptspsG.+FGIPu-clpP.hoYP-oPDhpclPCYFsEKsQ....plIQpEPspslYQpaLVHFPhsADlRlNDKllWc..shsYhLchP.+pl+s.HHhEVhAVR--.p.	0	2	3	4
+12040	PF12207	DUF3600		Domain of unknown function (DUF3600)	Mistry J, Gavin OL	lg7	pdb_3fgg	Domain	This family of proteins is found in bacteria. Proteins in this family are approximately 230 amino acids in length. This domain is the C terminal of the putative ecf-type sigma factor negative effector.	25.00	25.00	25.70	40.90	23.30	22.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.06	0.71	-4.70	6	85	2009-07-29 14:18:26	2009-07-29 15:18:26	3	1	85	4	6	63	0	158.60	80	75.11	CHANGED	SIMADGIYGSFENLKKHAGsMTLEuYMRFsAKLSEAKDEMGTKEYE.FTKELKKLTNAKLAYGDSNGNIDYDuLSPAKREEMKKVSMuLQPYFDKLNGHKSSKEVLTQEEFDRYMEALMTHEIVRVKTKSTGAIKVEEVPEAYKERFIKAEQFMEYVDEKVR	..SIMADGIYGSFENLKKHAGsMTLEAYMRFsAKLSEAKDEMGoKEYE.FTKELKKLTNAKLAYGDSNGNIDYDtLSPsKREEMKKVoMsLQPYFDKLNGH..KSSKEVLTQEEFDpYMEALMTHEIVpVKTKSTGuIKVEElPEAYKERFIKAEQFMEYVDEKVR........	0	1	4	5
+12041	PF12208	DUF3601		Domain of unknown function (DUF3601)	Mistry J, Gavin OL	lg7	pdb_3g1j	Domain	This domain family is found in bacteria, and is approximately 80 amino acids in length.	21.00	21.00	21.00	24.30	20.50	18.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.55	0.72	-4.04	6	50	2009-07-29 14:46:14	2009-07-29 15:46:14	3	1	32	2	6	48	0	82.00	55	54.34	CHANGED	s..phLhsGshV+VIKsF+DYhGhTapsGEpaaFAsshahPY-sGaTLYI..up-K....sIhLpsps-sptcIhsps.cEYFE.lp	..sF.cYLYSGDYlKVIKsFKDYYG.FTHpsGEcaYFAstYaL.aEsGhsLYI...SpDKlN...........lssIYLpDRt-s........p.clhsHs.EEYFEIlE.................	0	6	6	6
+12042	PF12209	SAC3		Leucine permease transcriptional regulator helical domain	Mistry J, Gavin OL	lg7	pdb_3fwc	Domain	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF03399. This domain is a helical domain in the middle of leucine permease transcriptional regulator.	25.00	25.00	32.80	31.80	23.10	20.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.49	0.72	-3.84	10	37	2009-07-29 14:46:34	2009-07-29 15:46:34	3	1	36	5	26	41	0	77.90	28	6.27	CHANGED	llpQlhsplhp-sIcsplpshlpshlpctpt+pp+ppl.IsoLScELacAFl+EplYhshLES+A-.ahs+hlKK+hhc+	.........h.hcplhspllppsVpsplpsllpp..hlpctptc..pt+tpl.IcoLucELYsAFl+EplYhhhl-o+A-.hhppplK++hhp.....	0	4	15	26
+12043	PF12210	Hrs_helical		Hepatocyte growth factor-regulated tyrosine kinase substrate	Mistry J, Gavin OL	lg7	pdb_3f1i	Domain	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00790, Pfam:PF01363, Pfam:PF02809. This domain is the helical region of Hrs which forms the core complex of ESCRT with STAM.	22.40	22.40	22.70	34.20	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.09	0.72	-3.73	5	116	2009-07-29 14:46:51	2009-07-29 15:46:51	3	7	82	1	70	114	0	93.20	61	13.22	CHANGED	EcFlsNlRouVElFsNRM+SNpuRGRSIuNDSAVQoLFQolosMHPQLLchlcpLDE+RhaYEuLQDKLuQI+DARAALDuLREEHcEKLR.RtAEE	......-pFlcuLpsuVosFVNRMKSNphRGRSIoNDSAV.oLFpoIssMHPQLLchlppLDE+RlYYEGLQDKLAQIRDARuALsALR-EHcEKLR.RtAEE.......	1	23	27	52
+12044	PF12211	LMWSLP_N		Low molecular weight S layer protein N terminal	Mistry J, Gavin OL	lg7	pdb_3cvz	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 328 and 381 amino acids in length. There is a conserved LGDG sequence motif. Clostridial species have a layer of surface proteins surrounding their membrane. This layer is comprised of a high molecular weight protein and a low molecular weight protein. This domain is the N terminal domain of the low molecular weight protein. It is a structural domain.	25.00	25.00	48.70	42.20	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.82	0.70	-4.54	19	115	2009-07-29 14:48:39	2009-07-29 15:48:39	3	2	9	4	1	110	0	234.00	34	61.87	CHANGED	spsYTVVQscYcKslKplQcGlpcssIosIsVhFD.Gp.ls..sVssttsssp.......AAspLhshV-sKLDsLGDGcYVDFpIoYssssphhT.ps-ls...shtstls....sclllssAss..sss...Gllh...tssssssssuAssslphSDlhchsh...ssspsuhpLohsspt.sshphGpl...........sssshssupslohsss..htlshucu.cplDlspShhhssssu.........hhsspssssssssspspVRVINAKEpTIDlDuSShpoAE	......................................sYTVVQscYcKslKplQcGlpcssIopltV.F-.Gp.lu..pVsstsssuc..t....AAcpLhshVcspLDsLGDG-YVDFpITYs....s....tschhT.pu-hc...shtspls....s+llIssAos.....ost.....GhVp...tssssspt.uAssslphuDhhphsh..sssspsuhploh.sstt.sshphGpl............tss.os.u.tslshsss.th.hthucs.chlDhs.....pShhhsssss.........hhsstsss.sssssspspVRVINAKEpTIDlDuSShpoAc.....	0	1	1	1
+12045	PF12212	PAZ_siRNAbind		Piwi/Argonaute/Zwille siRNA-binding domain	Mistry J, Gavin OL	lg7	pdb_3da5	Domain	This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There is a conserved LKDIL sequence motif. There is a single completely conserved residue L that may be functionally important. This domain is part of an Argonaute protein. It is an siRNA binding domain.	21.10	21.10	21.10	21.90	20.80	19.80	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.15	0.72	-4.34	10	42	2009-07-29 14:51:18	2009-07-29 15:51:18	3	6	8	5	16	37	0	45.80	56	46.23	CHANGED	AYAIlp+DSpsIEElL+luKENuILKDILsATtTIKasDucEtThTP	..sYAIhpKcShslEchL+luKENuILKDILsATsTIKYsDupEtThTP....	0	1	15	15
+12046	PF12213	Dpoe2NT		DNA polymerases epsilon N terminal	Mistry J, Gavin OL	lg7	pdb_2v6z	Domain	This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains.	21.50	21.50	21.80	22.30	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.10	0.72	-4.06	10	117	2009-07-29 14:53:03	2009-07-29 15:53:03	3	4	92	1	78	118	0	70.90	35	13.88	CHANGED	csc+LRp+lsusFKl+GLhLRuEAoKYLs-sLtulscsEhEDhl-+Il-sVcKQPLSSshlEcullEsAVQEC	..........s...tlRp+lhssFKL+GhhLRsEAhcYL...sctL............psh.s..ct.Eh-chL-pll-sl-KQs.LsSshl-+sslEtAlpEC.......	0	24	32	57
+12047	PF12214	TPX2_importin		Cell cycle regulated microtubule associated protein	Assefa S, Gavin OL	lg7	PFAM-B_2368 (release 23.0)	Family	This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with Pfam:PF06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain.	20.30	20.30	20.50	20.30	19.50	19.70	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.40	0.71	-4.19	10	167	2009-07-31 14:33:35	2009-07-31 15:33:35	3	9	75	0	104	164	0	147.30	34	25.41	CHANGED	s+t+lTsP+EPsLpTupRsRslRsKSsA-LEpEplppl..YKFKAR.lN++IhE.sussl.KKsssK.Ppch.uF+LcTpcRApcRuSsspppspphphpp+ss...hh.DssssPphpshssssP+sstsstcs+pchspp.cc..Kt+PLs.KI...........hcs+tp.u.hsct++ppssPhpFcs	.....................................s...hlTpPppP.LpTppRsRss...p.....sK..Ss.u..E.hEtEpltcl..........KF..K..AR.lsp+IhE..su......h.p+sss+..s.p..tFcL.chp....cRhp....p+pspt.p..t..ppt..........p...p....sp.s..............hh.s.st.s.h..h.hs.sppsthh.p.p.c...tt.......c.t.pPh.....hh............htst.........pt...hs.tF....................................................	0	26	56	72
+12048	PF12215	GBA2_N		beta-Glucocerebrosidase 2 N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2416 (release 23.0)	Family	This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 320 to 354 amino acids in length. This domain is found associated with Pfam:PF04685. This domain is found in the protein beta-Glucocerebrosidase 2. It is found just after the extreme N terminus. This protein is located in the ER. The N terminal is thought to be the luminal domain while the C terminal is the cytosolic domain. The catalytic domain of GBA-2 is unknown.	20.70	20.70	20.70	21.20	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.20	0.70	-5.27	38	367	2009-07-31 14:39:48	2009-07-31 15:39:48	3	14	220	0	196	361	64	289.80	26	35.26	CHANGED	GhPLGGhGuGsIuhus+GchshWpl..csGc.......aha..t.h.........pFula.p.psspstshsLssps.pss...................LssWpa.h........susYpAtYPhuahpac.s.shtsplphEtFSPllPtshpcSShPVAVFpaplpN.ssspslplSlhlSapNslGh.....hs.sptssthhhts.....................h.pssthpGllhps.pstp......spupGphslAs.ss..th...clhtpspWsssu.........sst-lWpsFst...DGpl.....................ptsttscphuuAlulchsltPGpscclsFsluWchPs..h...tFussspth...........+tYocFF..uttsp.sAhslAshALpphppa	.....................................................................GhPLGG.......lGuGsIspu.hcGpFppapl...psu......................................h................sspFslhhp..ps....tt.t.hhh...hs.sps.p.t................................................sltsWpa.hst......................tpspYpuLYPpuWh.Yc........s.....tlplshcthSPllPpsYpcS.ShPsulFhaplpN...s.s.p.hplolhhohp.N.slG...........t.stts.......................................................ttst.hpGllhpp.p........s.............s.......shsluspps...sh..........plshpst.as.su.............supphW..pphtp.....sGph......................................ttsstts..ppl....uuAlssp.htl.........Ptt.spp..lpFsLuWshP......h.......tFststpha............................RpYTcFa..upptp.su.pl....schALpphtph................................................................	0	63	110	161
+12049	PF12216	m04gp34like		Immune evasion protein	Assefa S, Gavin OL	lg7	PFAM-B_2496 (release 23.0)	Family	This protein is found in archaea and viruses. Proteins in this family are typically between 265 to 342 amino acids in length. The proteins in this family are or are related to the m04 encoded protein gp34 of pathogenic microorganisms such as murine cytomegalovirus. m06 and m152 genes are expressed earlier in the intracellular replication phases of these microorganism' life cycles. They function to inhibit MHC-1 loading and export. gp34 is theorized to prevent immune reactions from NK cells which would ordinarily recognise and attack cells lacking MHC.	25.00	25.00	29.40	29.10	23.20	24.70	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.87	0.70	-5.04	11	182	2009-07-31 14:41:40	2009-07-31 15:41:40	3	1	5	0	0	165	0	261.40	22	87.96	CHANGED	hShssR......................hhLlhllhhsshlhssssssspp..................Cp....p.ppthpphhphtps............htCahKctss...sphsss..sss.plhsCpLP...sVhVNAoWolEWll.sslpuSlsshuYapSossSsPpFptshhsah..phh.h....pp.ltsKsGF+VDpSs.....GNLaVasNAo.......ssscuV+C+LphChW..Tossshs..ss.........DcshhpshSsVLsLPDYssP.ths....h.+....ssasasptpps.sss..............lssLoVlVsLlaVsshslLhYhas..........spLhRRhhopDssspa	.............................................................................h.hhhhs.h....hs...h.ssspt..................ss......p..htt.....p...s..........htC.htppss......pphspp..sss.p.hasCpls...slplNAoWpscWll..sshss.......lsstshapSTsoSsPpFpthhsshhs.............sssssGFpVDpss.....GpLalhssss..........tsstslpCpLplClh...........sps.shh..ss..............................................................ppth.pshothhpLssat...t..........................s.ts.h.s.s...tp..thp........................t..hsslslhlshlh..ssshhh..LhhhYt..............s.hhcph.............................................................................................................	0	0	0	0
+12050	PF12217	End_beta_propel		Catalytic beta propeller domain of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is typically between 443 and 460 amino acids in length. This domain is the highly conserved beta propeller of bacteriophage endosialidase which represents the catalytically active part of the enzymes. This core domain forms stable SDS-resistant trimers. There is a nested beta barrel domain in this domain (Pfam:PF12195). The endosialidase protein complexes to form a homotrimeric molecule.	20.30	20.30	21.10	308.50	19.80	17.60	hmmbuild  -o /dev/null --hand HMM SEED	367	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.39	0.70	-5.77	3	30	2012-10-02 00:45:24	2009-08-03 10:19:26	3	7	24	18	2	29	0	420.90	83	47.65	CHANGED	NGELaKITDTPaYNAWTQDKTFVYDNVIYAPFMAGDRHGVsNLHVAWVRSGDDGQTWSTPEWLTDLHsDYPT......VNYHCMSMGVCRNRLFAVIETRTLSsNKLpsAELWDRPMSRSLHlTGGITKAANQQsATI+IsDHGLFAGDFVNFSNSAVTGVSGNMTVATVIDKNTFTVTTsNsQsSDlNNAG+oWsFGTSFHcSPWRKT-LGpIPS.ssushsVTElHSFATIDDNuF..AVGYHNGDVuPRELGlLYFSDAFsSPGsFVRRpIPuEYEsNASEPCVKYYDGVLYLTTRGTLuTpPGSSLHRSoDlGQoWsSLRFPNNVHHSNLPFAKVGD-LIIFGSERAFGEWEGGAPDsRYcGSYPRTFMsRVNVNsW..SLDDVEWVNITDQIYQGcIVNSAVGVGSVCVKDuWLYYIFGGEDFFNPWSIGDNsuKhPYKHDGHPADLYCYRlKIc	..QGELFKITDTPWYNAWTQDKTFVYDNVIYAPFMAGDRHGVNNLHVAWVRSGDDG+TWTTPEWLTDLHENYPT......VNYHCMSMGVVRNRLFAVIETRTVSGNKLQVAELWDRPMSRSLRlYGGITKAANQQVAYIRITDHGLFAGDFVNFSNSGVTGVTGNMTVTTVIDKNTFTVTTQNTQDVDQNNEGRYWSFGTSFHSSPWRKTSLGTIPSFVDGSTPVTEIHSFATISDNSF..AVGYHNGDIGPRELGILYFSDAFGSPGSFVRRRIPuE.YEANASEPCVKYYDGILYLTTRGTLSTQPGSSLHRSSDLGTSWNSLRFP.NNVHHSNLPFAKVGDELIIFGSERAFGEWEGGEPD...NRYAGNYPRTFMTRVNVNEW..SLDNVEWVNVTDQIYQGGIVNSAVGVGSVCIKDNWLYYIFGGEDFLNPWSIGDNNRKYP..YVHDGHPADLYCFRVKIK..	0	0	0	0
+12051	PF12218	End_N_terminal		N terminal extension of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. This domain is found in the bacteriophage protein endosialidase. The two N-terminal domains (this domain and the beta propeller) assemble in the compact 'cap' whereas the C-terminal domain forms an extended tail-like structure. The very N-terminal part of the 'cap' region (residues 246 to 312) holds the only alpha-helix of the protein and is presumably the residual part of the deleted N-terminal head-binding domain. The endosialidase protein complexes to form homotrimeric molecules.	22.20	22.20	22.40	27.30	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.26	0.72	-4.50	5	30	2009-12-16 16:06:22	2009-08-03 10:28:11	3	9	25	18	2	27	0	66.00	69	7.08	CHANGED	AlGDGVTDDTsAlousLuuossGpKIDGpGLTYKVSoLPDlSRFKNARFVaERIPGQPLaYVSE-FI	AlGDGVsDDToAlSshLusuosGpKIDGtGLTFKVSTLPDVSRFKNARFLFERIPGQPLFYsSEDFI......	0	0	0	0
+12052	PF12219	End_tail_spike		Catalytic domain of bacteriophage endosialidase	Mistry J, Gavin OL	lg7	pdb_1v0e	Domain	This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two conserved sequence motifs: VSR and YGA. This domain is the C terminal domain of the bacteriophage protein endosialidase. The endosialidase protein forms homotrimeric molecules and this domain complexes into a tail-spike stalk. The stalk region folds in a triple beta-helix that is interrupted by a small triple beta-prism domain. The tail-spike is a multifunctional protein device used by the phage to fulfill the following functions: (i) to adsorb to the bacterial polySia capsule (ii) to de-polymerise the capsule to gain access to the outer bacterial membrane, and finally (iii) to mediate tight adhesion to the membrane, a prerequisite for the initiation of the infection cycle.	25.00	25.00	26.40	113.20	24.00	22.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.86	0.71	-4.39	5	36	2009-08-03 10:56:41	2009-08-03 11:56:41	3	8	24	24	2	34	2	136.90	78	17.33	CHANGED	sDsRVSRDFsYGATPNRAIPTFMGTDGVRTVPAPLcFosplss.DlsVsHLTl+ASTSuNIRSEhhMEGEYGFIGKoVPoDsPTuQRLIlSGGEGTSSooGAQITLHGSNSSTuRRAVYNAsEHLFQuuslhPYlDNVsALGGPSNRFTTlYLGSsPIlT	.p-paVSRDFsYGATPNRTlPTFMuTsGVRTVPsPlcFoD.....DlsVpuLTl+AuTSupVRAEVphEGsYulIuKpVPoDssTuQRLIVSGGETTSSADGAMITLHGSsSSTPRRAVYNALEHLFENGDVKPYLDNVNALGGPGNRFSTVYLGSNPVVT	0	0	0	0
+12053	PF12220	U1snRNP70_N		U1 small nuclear ribonucleoprotein of 70kDa MW N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2533 (release 23.0)	Family	This domain is found in eukaryotes. This domain is about 90 amino acids in length. This domain is found associated with Pfam:PF00076. This domain is part of U1 snRNP, which is the pre-mRNA binding protein of the penta-snRNP spliceosome complex. It extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition.	21.90	21.90	21.90	22.60	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-3.66	37	328	2009-08-03 10:59:28	2009-08-03 11:59:28	3	7	272	0	222	311	0	93.50	35	26.69	CHANGED	MsptLPPsLLsLFtPRPPLpalsPh-psscc+ppst..loGlupaL..sthpchpc......p.s....ps..sEohhp++tRc+cEKppphppplpcplppasPppDs	.......MTphLPPNLLuLFsPRPPl.alPPh-+hP..c..c++pst............hsGlAsal......sph..cc.p-........................sss.......st..sEoppp+pcRc+.cEKh-ptp.pcl.cpplpp.acPppDP.................................	0	74	122	185
+12054	PF12221	HflK_N		Bacterial membrane protein N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2550 (release 23.0)	Family	This domain is found in bacteria. This domain is typically between 65 to 81 amino acids in length. This domain is found associated with Pfam:PF01145. This domain is the N terminal of the bacterial membrane protein HflK. HflK complexes with HflC to form a membrane protease which is modulated by the GTPase HflX. The N terminal domain of HflK is the membrane spanning region which anchors the protein in the bacterial membrane.	20.50	20.50	20.60	20.60	19.90	20.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.22	0.72	-4.21	70	1238	2009-08-03 15:45:40	2009-08-03 16:45:40	3	3	1224	0	245	716	1088	56.70	53	14.02	CHANGED	MuWN-Ps......ss.......p..pDPW....................Gp..sp..G....PPDLDElhRchpc+lsuh...FG....Gp...u	................................MAWNpPG................NNs......pcpDPWGssp..........................pss+GG+...-QG...............PPDLD-lFRKLs+KLGGh....hG..GKG.............	0	46	115	184
+12055	PF12222	PNGaseA		Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A	Assefa S, Gavin OL	lg7	PFAM-B_2578 (release 23.0)	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 558 and 775 amino acids in length. There is a conserved TGG sequence motif. PNGase A is a protein which cleaves glycopeptides.	19.70	19.70	26.80	21.00	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.53	0.70	-5.61	9	253	2009-08-03 15:52:16	2009-08-03 16:52:16	3	6	146	0	168	266	3	347.50	26	62.87	CHANGED	EsFplh.P.ssTs.......hp.hlhhstVFs.ShhpPaVs..lYhPPs....sashlhlNloV.pSpGpQaDRhAhhalssl.VFhsSTtE.ss.....Th.pDhohapsLhpts.ph.hsLuNhhscs..hTG.assslThhh..t...ssphsshhlPl.spto.shNh..uall..Psssshsp.h.lPssT.Rull.l.tpG.us.-EFWaSNl...................shREIQLYhDGlLAGVV.PaPlIaTGGls.haWRPlsuIsshsh+p..pIDlTPhLslhpcus...hplpVssLpsut......lososu..WsloGslhLals..............pus.lhuspPhhshsRhl...sh.ssGhsushpYp.suphplsh..........u.hpacpulcaSssu.hsp.shsQs.....hhptshlspphtt.s.....hpssplhash..Pl	............................................................................P.......................................sthhlhptsF....u.oh.s.p.P.hh...............hs.P..s.s............s.........s...a.....s....h...lllphps..p....spGpQaD.Rl..shla...ls......ss-lh....RoSTsEP...p.s.t..u...l..h.Wsh.KDlopY..sLh.....p...t...s..t..p..lhh.L.sNllssp........hTG.apsslohtha................................t......t................................................................t................................u.........Dhll................P...lstt.............s..........h.l.................s.tpp..h.......t...ph....lP.....p.NshRshlplhs.ssp..us..-.EF.W..Ys..Ns.................................................u...u.......saREV.lh.l.........Du....plsGshhPaPlIaT.GG..l...s.....Ph.hWcPlsulsuFsl.s.hcl-lTPaLsh.L...hD.up.......HphthpVs....s.h....................................................................Whlsutlhla.s......................t....h..........................t..h..................t...t.........h...........h.........h...t...h........................h.p..thth.....p....tt...h...................................................t.................................................................................................................................	0	42	102	147
+12056	PF12223	DUF3602		Protein of unknown function (DUF3602)	Assefa S, Gavin OL	lg7	PFAM-B_2582 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 78 and 89 amino acids in length.	20.60	20.60	21.60	20.60	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.41	0.72	-3.59	33	384	2009-08-03 16:04:58	2009-08-03 17:04:58	3	4	131	0	289	349	0	70.60	22	57.83	CHANGED	NIh..ssp......tspsssttls..pt..osshpsst......a.oTGRGGuGNht.....ssp..thsRphpDh-..h.css.cpsph..............sGRGGsGN	..................................................................t...p..ss.tsst...............a.soGRGGAGNht........t.p..st.pR.t.psh-.....p.t..t...........................hs...................................	0	77	157	240
+12058	PF12224	Amidoligase_2		Putative amidoligase enzyme	Bateman A	agb	Iyer L	Family	This family of proteins are likely to act as amidoligase enzymes [1] Protein in this family are found in conserved gene neighborhoods encoding a glutamine amidotransferase-like thiol peptidase (in proteobacteria) or an Aig2 family cyclotransferase protein (in firmicutes) [1].	23.60	23.60	25.70	23.60	23.50	23.20	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.69	0.70	-4.77	53	463	2012-10-02 17:21:26	2009-08-04 10:24:11	3	7	264	0	248	457	70	231.20	19	63.15	CHANGED	pppphGlElE.hs.......GlshppsuphlsphhGs.psppt..............................thtthpl...................tssph............spaclhhDuSlhppppttt...................................................hshElVoPslphpp....lpplpclhctL+csGAhs.ssS..sGhHlHlsspshs...spslpshlphhhthpchlhcthplsh...R+hs.as..cshspphlcp..........hh....ssshpplhchah..tsscsps.......sth.ttphhpt.lshp.hhp.+s...TlEaRh.s.........uslcsschpthlphshtls	.................................................................................................................t...phGlElE.hh..........................................shs.tp.ph.sp..htphhss...ph.................................................................hth..............................................................................................t..ph..................................tpWplhtDu.Sltstpt.........................................................hshElVSP.hlthpp......hp.plp.pl............hp............tL....cpt.s.shs.spo..........CGhHlHl...s..........s..............s.s...............h.....s........hps..l+s.lhph...h...hhhE.sh...lhphhshs............c+...p..a.....s.......ps.hs.pt.hhpp............................h......sht..tl...p.....hhh........p....t...................h.tt......ptath...lNhpthhp.cs...........TlEaRh.s..............ushptsphpthlthshhh.........................................................................................................................	0	90	169	223
+12059	PF12225	MTHFR_C		Methylene-tetrahydrofolate reductase C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2600 (release 23.0)	Family	This family is found in bacteria and archaea, and is approximately 100 amino acids in length. There is a conserved NGPCGG sequence motif. This family is the C terminal of methylene-tetrahydrofolate reductase. This protein reduces FAD using the reducing equivalents from reduced FAD, subsequently reduces tetrahydrofolate. The C terminal of MTHFR contains the FAD binding site and is the catalytic portion of the enzyme.	20.20	20.20	24.20	23.50	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.58	0.72	-11.03	0.72	-4.49	33	210	2009-08-04 10:43:33	2009-08-04 11:43:33	3	6	173	0	95	202	48	93.30	36	30.57	CHANGED	lhsuhssh.hhusppththhhpp..CpsCGpChLspTGslCPhs.CPKuLhNGPCGGs.psG.+CEVss-.tcClWphIYcRlcphsph-p.lpplhPPt-appp	..............h...t.sphhhthppththhh.t..CpsCGpChLspTuhlCPhs.CsKsLhNGPCGGs..psG.pCEls......s.....p..tcCsW.hhac+hcthsph-t.htpl.hsshshp.h................	1	52	74	83
+12060	PF12226	Astro_capsid_p		Turkey astrovirus capsid protein	Assefa S, Gavin OL	lg7	PFAM-B_2608 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 241 and 261 amino acids in length. These proteins are capsid proteins from various astrovirus strains.	25.00	25.00	29.10	28.40	18.70	16.40	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.45	0.70	-5.12	3	174	2009-08-04 10:47:39	2009-08-04 11:47:39	3	3	7	4	0	161	0	208.40	83	61.93	CHANGED	YFVYDFQGcRVSTTETGVFCLuSIPAADSKSRYNNQIToPSIGYRN-SGTGTSFALDuASWWNILDVTQTGVIFGQPRLGVGVIQTMKTLKQHIKDFTEPAVKKYYPGTTNLDQpLKsRLNLAEGDPVISMGDTTGRRAALFYRTSDERFILLFSTTDDPGuQYpSLKMLsFWNWSLSDsKsAFLA+LRTVQFANLs....-SEsupCDSDDDDLSDVTSLFEQADLGDETDFK	......................YFVYNFQG-RVSTTETGVFCLAAIPAATTTSRYNNQITTPSIGYRNASGTGTSFLLDAASWWNILDVTQTGVLFGQPRLGVGVhQTMKTLKQHIKDYTEPAIQKYYPGTTNLDE..Q..LKQRLNLAEGDPVISMGDTTGRRAALFYRTSDEKYILFFSTTEDPGAQYQNLKMLYFWNWSYSDTKQQFLDHLRTVQFANLD....DSQPAPYDSDDDDLSDVTSLFEQADLGDETDFK..	0	0	0	0
+12061	PF12227	DUF3603		Protein of unknown function (DUF3603)	Assefa S, Gavin OL	lg7	PFAM-B_2609 (release 23.0)	Family	This protein is found in bacteria and eukaryotes. Proteins in this family are about 250 amino acids in length.	23.70	23.70	52.10	51.80	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.37	0.70	-5.20	9	135	2009-08-04 10:58:43	2009-08-04 11:58:43	3	1	135	0	20	77	0	214.10	77	86.22	CHANGED	LLDQVPLLKVss.LacYIEN-LS-LPppLLp-VaQKuYlRKNHERhQL-YCFVVTDGpsIlAVDTlGYpIPIRKSRLIPRQEQLVYEMlcstcs.pYphp.cphp..KEYHILSPsPphhsGLTRKERQLKQLLFMALDQL+oopNpAEIRYWhTEWsPppYspIQpMsFE-sWppLYcEs+pGWS-+H.phCEsLIKGQPFFEKLWEhEptsKVN	.LLDQVPLLKVDuTLYHYIENELLELPQKLLEDVHHKAYIRKN..HERL..QQEYCFVVTDGKG..IIAIDTIGYNVPIRKSRLIPRQE.....QMVYEMVENVQAE..KYEFQlEEhE...KEHHIL....SPSPalMNGLTRKERQLKQLLFMALDQLHTTKNTAEIRYWaTEWDPSAY..GhVQHM-FEDIWs+LY-EAKsGWS-KHEQLCERLVKGQPFFEKLWEMENEpKVN..............	0	3	12	14
+12062	PF12228	DUF3604		Protein of unknown function (DUF3604)	Assefa S, Gavin OL	lg7	PFAM-B_2610 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 621 and 693 amino acids in length.	20.40	20.40	20.80	20.60	19.80	20.30	hmmbuild  -o /dev/null HMM SEED	592	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.16	0.70	-13.00	0.70	-6.35	34	171	2012-10-03 00:45:34	2009-08-04 12:52:57	3	2	97	0	20	168	1789	367.20	26	62.25	CHANGED	ssscpsYaGDhHlHTshShDAhhhGs.phsP--AYRaA+G-sl......tps.sG....h.spLscPLDFhsVoDHA-hhGhhpthhssssth.....tpshtp.h.thhhpss.pssttshhhhsshsss.hspsht...tss.t....................htpssWpphlpsA-paNcPG...pFTshlGaEWTutss..usNLHRsVIaRsssphs.phlPFos...hpSssPccLWsahcshcppsuup.....hLAIPHNuNhSNGhMF..thsshs...GpslDtsYAcpRt+hEPlsElTQlKGsSE....sHPhLSPsDEaAsFEh..achushshssttssphh........sYsRsALpcGLplEpphGsNPYKFGhIGSTDoHTuhso.s-EsNFaGKhus.spss..ptphs............tt.............ppthph......uASGlAuVWAc-NTREAIaDAhcR+EsYAToGPRlpVRFFuGasaspsshpss-hsptuYucGVPMGusL........ssup.APsFLlhAh+D.....P.puAsLDRlQllKGWl-.ssGpspEpVYDVAh..Scspphssssph.sslGsoVDlsssoaosslGAsELpslWpDPDFcssQpAFYYlRVLElPTsRWosaDAl+hGhp...........ssPt..TIQERAaoSPIWYsP	............................................s...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...........huuGLsuVaApcpoR-ulh-Ahtp+csYAToGsRlh..lpF.............t.................................................................................................................................................................................................................................................................................................................	0	8	10	14
+12063	PF12229	PG_binding_4		Putative peptidoglycan binding domain	Bateman A	agb	Bateman A	Domain	This domain is found associated with the L,D-transpeptidase domain Pfam:PF03734.  The structure of this domain has been solved and shows a mixed alpha-beta fold composed of nine beta strands and four alpha helices. This domain is usually found to be duplicated. Therefore, it seems likely that this domain acts to bind the two unlinked peptidoglycan chains and bring them into close association so they can be cross linked by the transpeptidase domain (Bateman A pers. observation).	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.30	0.71	-3.85	117	1823	2009-08-04 15:04:53	2009-08-04 16:04:53	3	16	849	4	342	1540	49	115.10	15	32.20	CHANGED	hshsspcls.hph.shsphlppshshstssshh.phhtphht.........phs....hplshccpt....lpphlspl......spphsptsp..sAphph......ssss...hsls.s.pphG....hpl.ctcph...hpplhpslpss.ppshp	...........................................................................................t.pp.lt..hth..phpphlpt.hhsh..pht.t.ph.h....phhtp...phtt..............phs.........hphshDp.pt....l.p.sh.ls.pl......spph.sstsp...suphph......ss.ss......hslt..s...tp....G....hpl.Dtcph.tptlhpslpst.pt.................................	0	165	288	322
+12064	PF12230	PRP21_like_P		Pre-mRNA splicing factor PRP21 like protein	Assefa S, Gavin OL	lg7	PFAM-B_2642 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with Pfam:PF01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.	24.50	24.50	24.60	25.90	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.53	0.70	-4.85	16	364	2009-08-04 15:43:10	2009-08-04 16:43:10	3	14	282	1	262	366	5	219.60	28	38.44	CHANGED	spshppplcpt..ps.....lLccshpRu-atcpp+ppcpcpc-tpEcc+hpaAuIDWpDFslVtTl-Fsct-.ht-LP.P.lshspLhttoLpp+ppshp..tpss......................pstpcccs-psspsssss..........pthphtsuspuplKlpcshpspspp.ts...........hhhCPIoGchIPtschspHh+l.LlDP+...a+cQ+cph.t+ppp...ophssspVhpNlKpluc+	...................................................................h......plppp..ps.hp...lL-psh.Rs-Wt+apcpp+p+c--ctEpE+ltaAp..IDWHDFVVVET.lcFp.........s-...psphPs...........P.ho..p..-l.ttt.L...p....ct.......h........t....t..tptht.....t.......t............................................................................p..p.pt..c..ct.tpspt.t..................................t..h...s..s..s....s....t...s.th......hlpcsYssptpp.h..............ss.thhlsPlsuppIPhschpcHMRItLlDP+...WhEQ+c+....tch.tp....s.hss.-ltpsL+pLAp......................................................	0	89	148	218
+12065	PF12231	Rif1_N		Rap1-interacting factor 1 N terminal	Assefa S, Gavin OL, Eberhardt R	lg7	PFAM-B_2647 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 135 and 146 amino acids in length. Rif1 is a protein which interacts with Rap1 to regulate telomere length. Interaction with telomeres limits their length. The N terminal region contains many HEAT- and ARMADILLO- type repeats. These are helical folds which form extended curved proteins or RNA interface surfaces.	23.00	23.00	25.60	23.50	19.20	20.50	hmmbuild  -o /dev/null HMM SEED	372	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-12.00	0.70	-5.49	34	226	2009-08-04 15:44:22	2009-08-04 16:44:22	3	4	185	0	157	234	1	323.80	22	19.96	CHANGED	QLAGsscsS+lDAYhp..LhsuLpuhsslPsptsltpKhsLhspaIpRDls............tp.spus..-spLsppALpLLshhlapspIuuplssDFsh.....Fll-+slsshpssshPKslspchhpllupQsFss+lhTssRls+llssLcsIspp.lpGpullhpRLsIYp+LlpQstphMhscus.Whs......pllsshLpshK-lRpp.AlsLuhphuhslG.....................pppplu+slh-lhspslpsp...phhp.htp+LppMhss..cs...ushVPpIWulllLLL..Rsth..lcpWpahppWlhllQtCFNss-...sKhpAhhAWs+hla.....shpssppsspchlphLhpPl.hsQLc++pssc.t....phpphslsuhtsLL..YYuF+Pss..s.phLDhhWsphl	...........................................................................................................hcsa.....h.t.hhph..pt.......tl...pphshhhphhpp..clt..................s........s.pLsptALphlshhlhpsplsstlspp.h...................l.pslp...sh..ts......sKslhpthhhl.....luh.........QpFs....sc........lh..s.pt..h.....sp..h.lhshhh.h.pp...hputsl.hptlt...............lhh.......pLlpph.t...Mhpp...ss...hWht............................llshhl.p....s..spclp.p.....A.....hslt....hth.s.h.hlt...............................ppt.l..uphh.t.phhspt..h......sp............lpphhts..ps...tshs.plWshhlhLL...tpph.........hcshsahsphLpl..phsFps.s...ss..h+t.AhhuWctll......................shp.....s.h..s..s....t..chlch.LhpPl...p.lcpct.s.h.t....phh.hllh.....pltshl.....h..sF...c...ss...s....t.h..................................................................................................	0	31	70	124
+12066	PF12232	Myf5		Myogenic determination factor 5	Assefa S	lg7	PFAM-B_2654 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00010, Pfam:PF01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.	21.70	21.70	21.70	21.70	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.87	0.72	-3.37	28	259	2009-08-04 15:48:27	2009-08-04 16:48:27	3	5	107	0	76	227	0	63.60	47	25.66	CHANGED	.paYuus.....S-uoSPp.SsCSDGMsDhsu.P.shopcpssa..sus.Yhspsss.sspssKsssl.SSLDCLSSIV-RI	..............................paYShs.....S-soSPp...SNCSD.G.Mh..........-hsu...P.shspcpssa......cus.Yhspsss...s....tss.+sssl..SSLDCLSSIV-RI..............	0	9	13	35
+12067	PF12233	p12I		Human adult T cell leukemia/lymphoma virus protein	Assefa S, Gavin OL	lg7	PFAM-B_2655 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are approximately 100 amino acids in length. p12I binds to the immature beta and gamma-c chains of the interleukin-2 receptor retarding their translocation to the plasma membrane. p12I forms dimers which bind to these chains.	25.00	25.00	138.40	138.20	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.66	0.72	-3.72	2	51	2009-12-01 16:56:24	2009-08-05 16:42:23	3	1	3	0	0	51	0	97.90	96	100.00	CHANGED	MLFRLLSPLSPLALTALLLFLLSPGDVSuLLLR.PPAPCLLLFLPFQILSNLLFLLFLPLFFsLPLLLSPSLPITMRFPARWRFLPW+APsQPAAAFLF	MLFRLLSPLSPLALTALLLFLLsPGDVSGLLLRPPPAPCLLLFLPFQILSNLLFLLFLPLFFSLPLLLSPSLPITMRFPARWRFLPWRAPSQPAAAFLF	0	0	0	0
+12068	PF12234	Rav1p_C		RAVE protein 1 C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2692 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.	20.80	20.80	20.90	20.80	17.50	20.30	hmmbuild  -o /dev/null HMM SEED	631	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-13.08	0.70	-6.36	13	405	2009-08-05 15:44:38	2009-08-05 16:44:38	3	26	270	0	281	395	1	467.30	29	21.95	CHANGED	Ghl+oac.Ahl.....sscppclcWhhs.pplpTGIpNsoLhoGSS.hsKsulV...Dps+ppLTIWDs+puh....LEYcccF......c-pIpDLDWTSTscsQSIlulGFsp+VlLhoQLR.....YDYsNpsPoahsI+clsIpshTsHsIGDSsWhssGslVVuoGNQLFlhD+pl-........spsolsophhhss......DLhclsShLNGPL.PVYHPQFLhQslluGKlsLV+cILLpLappL+hhp..ps.hc-l-SsLsls.pcFh...pss..htth.........................sc.hpshscsluusLsEpLo.chsLPhLopHpQhpLhsllEsVspVpKpccshD.NuhRFlLsh+.....ah.++sp....psSlohR-lsWAhHScsp-ILhshlspphp..h.WpcAREstlhhWhp-.ssLhspFEs.lA+tEaoKs-c+DPscCulaYLAL+KKpVLpuLWRhAshH.EQsphh+FLuNsF.sEsRW+TAALKNAaALLSK+RYhhAAuFFLLADsL+DAVNVlhpQLcDlsLAIAVsRVYEGD.sGPlLtElLcpclLPpAhp-usRWhsSasaWhL+++-hAlRALloshhsLhpspshssp..s....hsKSFLs-DPALllLYppLRpKsLpplpGu...cVss+hEa-hlL+suclYsRMGCDhLALsL	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................th..................................................................................................................................................t....t.hh.s......ph.s.t.lpt.Lh..p..tLP.LophpQh.Lhslh....-sltt.h..........p............p....p...........p...........c.........o.....lD-sGh..R.al.....Lsh+...................ah........hhpsp.....................h.p..p..s.....l..shp.....c.....hsWAhHSp..u.p.-.L.......ls.hl.st.tcs.............p.pWpp.hRthGlsaWlcs..ps.L..................Rpph......Ep...lA+....st...ap.....c..........................t....p....DP..l.D.s........ulaYLA.h+.K.K.sllhGLaR................spcp...p+htpF.h.u.psF....s-sRWRpA.ALK.NAauLLuKpRFc...................huAAFFLLA..s..s..L+DAl........pVCl..pplpDlQLAlsIuRl..YE...................u......-......s.................u.......s.......s...h..p...........p...lLppc.lL........s.......................s.............p............p...................s...........s...........ahtShsaWhlpchs.A..lcsLlp......p.........p.......................................................................................................................................................................................................	0	95	142	225
+12069	PF12235	FXR1P_C		Fragile X-related 1 protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2701 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 126 and 160 amino acids in length. The family is found in association with Pfam:PF05641, Pfam:PF00013. This family is the C terminal region of the fragile X related 1 protein FXR1P. FXR1P contains two KH domains and a RGG box that are characteristic motifs in RNA-binding proteins as well as nuclear localization and export signals. FXR1P is thought to regulate mRNA transport and translation.	26.60	26.60	28.30	27.70	23.80	26.40	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.45	0.71	-4.11	9	307	2009-08-05 15:45:56	2009-08-05 16:45:56	3	10	42	1	87	266	0	115.40	58	24.25	CHANGED	VEQLRLERLQIDEQLRQIGhG.RssssRs......-+E+GYhoD-u....ssol+soR....sYssRGRGRRGsshsp...GTNSEhSNsSETES-++cE.Sshuluup-.-..Rps..ptt.stRR..tGtGRG..uGRGR.Gss+ssssohuSshcs.DsNPY.SLhcssEss	...........V-QLRhERLQIDEQLRQI.G.u.....ps.st.........tptth...-ts........p.u.oR....sYts.R.G+GR...RGss..hs.o..........................GTNS-..hSNsSETES-++-ElSDhSlusp-.-....R-....s....h.pRs.stRR.....GGtGRu...uuRGR.....G...s.+sspsp...Shhcs.spNPh.uhhcss-s.p....................	0	6	12	33
+12070	PF12236	Head-tail_con		Bacteriophage head to tail connecting protein	Assefa S, Gavin OL	lg7	PFAM-B_2709 (release 23.0)	Family	This family of head-tail connector proteins is found in bacteria and viruses. Proteins in this family are typically between 516 and 555 amino acids in length.  This protein is found in Phage T7 and T3 among others.	19.90	19.90	20.20	20.70	17.70	19.80	hmmbuild  -o /dev/null HMM SEED	480	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.11	0.70	-6.12	28	301	2009-09-11 16:20:59	2009-08-05 16:50:28	3	2	253	0	33	273	923	417.40	20	87.51	CHANGED	appl+scRpsacs+hc-hucaslPthhshtss......ptsppphpphapususculpsLAupLhtulhPsspsWF+Lslss......pt.spttsplcthLsplp+h...hhphhps..ssahssltpshpcLlssGsuhlhhtp......p..shsthpshslspaslpcDs.pGs.l-hlh+.......t..pchuh..cslspplppthpst........cspcplclhptlh.c..............spsh.asshh.spstts..hlpcushcphPalssRapchsGE....sYGcu..st-hLsDl+sLpplpcthlcutphsspshhllsssuhhpstsltsuutshh.stsstsshshhsl.pptsc.hssuttslpslcpRlppuahhs.h.......psupchTApElphpspEhtphLGslhuthspEhlpPllpRshthht..+suh...lPs.....hPp...th.......lcsshhosLstht+tt.shsulpphhshlutluthtsslhstlshsphhctlusthGhs.ssllpoppp	.................................................................................................................................................................tthcstR.psacsphpchtchhhPphh.h.pt.......................tppp...pphhpssustuhp.Luutlhtslhs.sp.ahclph.p...............p..tt..lc.hlptlpph...h.phhpp.....sshh.th.phhhplhshGsuhh.hl.p..........t.th.thp.hslsphhltpss.pu.p.lshlh+..........pc.hsh..stlscphp.pthpp..........................p.pcpl...cl.hphlh.p.................tpshsatshh.......tshp........hhpp.sshpthPhhssRa.hhss-....sYGpu..s.phlsshctLp.hppthhphhthshp.s.hh.sssshhhp...tsltsushshh...s........s....ttt...thh.h..........ss.hsssht.hpphcpplppshhhs.h.........tsspphTApElh.htpEhtthLGshhphhpp-hhtPllpphhthh...cts.............ls........Pp.......h..............h...c.ph.oshstht+t..thssltphh....th...h...utl..hth...s.p..h.h.s..tlshsthhpthsth.Ghs..thhhs.t................................................................................................	0	12	23	30
+12071	PF12237	PCIF1_WW		Phosphorylated CTD interacting factor 1 WW domain	Assefa S, Gavin OL	lg7	PFAM-B_2805 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.	25.00	25.00	25.20	25.20	23.90	24.20	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.32	0.71	-4.98	14	172	2009-08-05 15:54:26	2009-08-05 16:54:26	3	8	108	0	110	164	19	167.70	39	24.91	CHANGED	KLcpLYcps.......s.c..stc.phFhtplaslLhRY.pshh....st...usGhQuALstsVF-sL+ppasVohECFASPLNsha.....tpaCSAF.......sDsDtaFGShGsFhs..apPspG....SFEsNPPFscElhsthsp+htplL...........ss.uppsLSFlVllP.tWtpssh..hpphppStappps.hllsutpHtYhcG	........................................................t.....stt.chF.h.+lasLLhRY...pshh........Gs...t.............t...upuhQuulPspVF-sL+ctFs.........Vs..hECFASPLN..saa...........................ppYCSAF.......sDTDsaFGShGs...hh-......FpPhuG....................SFEsNP...........PFscELhcthssHh.c.cLL.................ts.ospPLSFl..VhlP.pWcps.s...........hpphcpShapRpp....hll.shp.HtYhpG.......................................................................................	1	49	62	89
+12072	PF12238	MSA-2c		Merozoite surface antigen 2c	Assefa S, Gavin OL	lg7	PFAM-B_2755 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species.	20.60	20.60	56.90	20.60	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.41	0.71	-4.65	14	159	2009-08-05 15:54:32	2009-08-05 16:54:32	3	2	1	0	4	148	0	182.00	36	75.26	CHANGED	VsMPSDsSpDALsAhh-ILcslK-clPFcTSLFDptVLpsL-hQ-sDplFcSLl.RVsLIKphLotFNuFLN..DNPt+hLssppsEMTKYYKKHIsscDspVKDYshLVKFCNDFLDSESPFM+hYKthNpY-EL...VcKtPupssSPs.SSsQusoss.pPupsssu.soossstsus.s.............psscPAcospss.............uuSFTFGGLTVA	.....................................VsM.ussupcshcALhtlhtllKpcsPFpTS.FDs.slc.hshQss--lFKhLl-ulhhhchhlpchNuFls...pssch.sphcschpcYYhcpIhscpup...h.shstLsphhpsFlsspushhhh..........cth.........ppa..........-...........s+.Kt.tps..p.h.sSspspsps....pPupspso............................................AspPs+PApospss.................GSSFTaGGLTVA.......................................................	1	4	4	4
+12073	PF12239	DUF3605		Protein of unknown function (DUF3605)	Assefa S, Gavin OL	lg7	PFAM-B_2795 (release 23.0)	Family	This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 161 and 256 amino acids in length.	23.30	23.30	23.60	23.90	21.80	23.20	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.13	0.71	-4.39	21	242	2009-08-05 15:54:41	2009-08-05 16:54:41	3	9	139	0	185	240	3	143.70	31	61.71	CHANGED	hsWppl+cIlpsNcL-hhpR.PStLc+YlcapccltupY.GSlhcallpc+Lt..W.s.sp.cth........tstPFt.spDh+lLhNDaPYulE.slsHLVVWoKhtL..sDsso..sDlsscuRpcI-cFVccsFhp+h........ss-pVlWF+NWpuLpSV+ulEHh.HVhlhp	.................................sWpplppllt....p..sp...LphhpRtssphc+Y.ht.aptplctp.a.uolhpalltp+Lt..W.t..s..t......................................shs.F.tp....s......sD...h+lLhNDWPYul..p.sl.sHlVVWoKh.l....s.c.ts................scho.psRt.lppalpcp.Fht+h...............stpplhWF+NahsLpSV+ulpHhHVhlhs..............................	0	53	101	154
+12074	PF12240	Angiomotin_C		Angiomotin C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2808 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 197 and 211 amino acids in length. This family is the C terminal region of angiomotin. Angiomotin regulates the action of angiogenesis inhibitor angiostatin [1]. The C terminal region of angiomotin appears to be involved in directing the protein chemotactically [2].	23.20	23.20	23.30	24.20	22.50	23.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.51	0.71	-4.82	8	207	2009-08-05 15:55:09	2009-08-05 16:55:09	3	5	58	0	103	167	2	196.00	58	24.48	CHANGED	YVEKVERLQpALsQLQAACEKREQLEhRLRTRLEpELcSLRsQQ+Qupssuuosus.....hssssLpEpLREKEERILALEADhT+WEQKYLEESsMRpFAMDAAATAAAQRDTT..IIsHSPssSh.soSh.......pEElhsAN+RsQEMEsRIKsLaAQIlEKDAhIKVLQQRSR+-suKs-psS............LRPA+SlsSI.su...tsoshpu+spoLoss	.....................YVEKVE+LQQALsQLQAACEKREQLEhRLRTRLEpELcuLRhQ.Q......R......Q...u........sst.ss..s.ssp................hsAssLhEh.LREKEE+ILALEADMTKWEQKY.LEEssMRpFAhDAA...........ATsAAQ.R..DTT.....lIsHSsssSh..soSh...........pEEllhAs+Rpt-MEsR...IKsLHAQIlEKDAMIKVLQQRS.....RK-s.uKss..psS............hRPA+Sl.SItsA.....ssGh.uhpoo.p..s.............................	0	15	25	53
+12075	PF12241	Enoyl_reductase		Trans-2-enoyl-CoA reductase catalytic region	Vella Briffa B, Coggill P	pcc	Pfam-B_10602 (release 10.0)	Family	This family of trans-2-enoyl-CoA reductases, EC:1.3.1.44, carries the the catalytic sites of the enzyme, characterised by the conserved sequence motifs: YNThhhFxK, and YShAPxR. In Euglena where the enzyme has been characterised it catalyses the reduction of enoyl-CoA to acyl-CoA in an unusual fatty acid pathway in mitochondria. the whole path performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation.	30.10	30.10	30.30	31.70	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.32	0.70	-5.38	49	655	2012-10-10 17:06:42	2009-08-06 14:20:28	3	4	531	5	162	543	120	236.20	56	59.63	CHANGED	++sGoAGWYNssAFcctAcptGLaA+SlNGDAFSsEhKppsI-hIKp-h.Gp.lDLVlYSLAoPhRpcPc....TGclapSsLKPIGpsaospslD.hccc...plt-sol-PAo--EItsTlpVMGGEDWphWlcALpcAsVLA-Gs+TlAYSYIGs-lTaPIYhcGTlGcAKcDL-psAtslspcLus.hsGpAaVoVhKAlVTQASuAIPlhPLYluhLaKVMK-cGhHEGCIEQhpRLFpcpLY	......t.KsGTAGWYNsAAFc+hAcptGLYA+SlNGDAFSsEhKppsI...-hIKp.....DL...G...p.VDLVVYSLA....SPhRpp.Pc.........TGEla+SsLKPIGcs......h.oupulD..Ts+-....slhEsolEPA........T.-p.EIpsTVsVMGGEDWchWI-ALtcAGVLA-GsKTlAaSYIGs-lTaPIYacGolG+AKhDLDpsupuLsp+Lus.hG....GsAhVuVLKAVVTQASS..AIPsMPLYluhLFKVMKEcGsHEGCIEQl.RLFp-+LY...............	0	43	84	122
+12076	PF12242	Eno-Rase_NADH_b		NAD(P)H binding domain of trans-2-enoyl-CoA reductase	Vella Briffa B, Coggill P	pcc	Pfam-B_10602 (release 10.0)	Family	This family carries the region of the enzyme trans-2-enoyl-CoA reductase, EC:1.3.1.44, which binds NAD(P)H. The activity of the enzyme was characterised in Euglena where an unusual fatty acid synthesis path-way in the mitochondria performs a malonyl-CoA independent synthesis of fatty acids leading to accumulation of wax esters, which serve as the sink for electrons stemming from glycolytic ATP synthesis and pyruvate oxidation. The full enzyme catalyses the reduction of enoyl-CoA to acyl-CoA. The binding site is conserved as GA/CSpGYG, where p is any polar residue [1].	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.64	0.72	-4.19	44	648	2012-10-10 17:06:42	2009-08-06 14:30:23	3	3	537	5	165	901	265	78.60	60	19.95	CHANGED	lIcP+l+GhICposHPhGCptsVppQIsYl+s...pstl.sG...PK+.......VLVlGASoGaGLASRIssAF.GssAsTlGVhFE+sso.-	.....................................IIKP+lRGFICsTsHPsGCEtsVccQIsYlKs..........pGsI..tsG............PK+...............VLVlGASoGYGLAuRIuAAF.GuGAsTlGVFFE+suo.........................	0	43	86	123
+12077	PF12243	CTK3		CTD kinase subunit gamma CTK3	Wood V, Coggill P	pcc	Pfam-B_12814 (release 23.0)	Domain	The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation [1]. The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2 [2].	33.70	33.70	33.70	33.70	33.50	33.50	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.55	0.71	-4.54	9	129	2009-08-07 14:05:10	2009-08-07 15:05:10	3	5	116	0	105	123	0	134.20	37	32.69	CHANGED	hDPFEVRhpFoshLp+LsAShpShpKAApaALKa.pDh-EDLasCILEpLEcs..shNsRsNIhaFl-p.hsE.shpps......pssYlchlpRDlh+lVDsVsPcsssst.ANlpsVR+lLpslpp+phls.pplp-l..........tsLcsRc	........hDPFEVRhpFos.Lp.+LsAShpShQKAApaALKa..+-hsEDLasCILEpLE+s..................shNs..RsNIhYFI-p.lh-huppps.......................p.sYlchl....pRDlh+lV.-uVsPsssu........u...h....sNl+ps++.....VLpslps+phLss.phlpcl..........t.lpt+..............................	0	32	62	90
+12078	PF12244	DUF3606		Protein of unknown function (DUF3606)	Assefa S, Gavin OL	lg7	PFAM-B_2813 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 85 amino acids in length. There is a single completely conserved residue G that may be functionally important.	20.80	20.80	21.30	23.80	20.50	19.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.19	0.72	-4.34	28	202	2009-08-07 15:46:44	2009-08-07 16:46:44	3	2	117	0	106	199	9	55.80	27	86.33	CHANGED	sssps+tsstDpsplsls-phElpYWs+chslopspLcpAVcpVGssspsVcpcLsp	..................tpppttstD+splshs-paElpYWs+chslotppLcpAVcpVGss.sppVctaLt...........	1	18	48	69
+12079	PF12245	Big_3_2	DUF3607;	Bacterial Ig-like domain (group 3)	Assefa S, Gavin OL	lg7	PFAM-B_2816 (release 23.0)	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	27.00	5.00	27.00	5.00	26.90	4.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-8.71	0.72	-4.41	11	1694	2012-10-03 16:25:20	2009-08-07 16:47:49	3	301	461	0	392	7792	931	42.20	24	4.75	CHANGED	sustps.....tpsstSshhPsushc-.aolpFhlhDpAGNpsphshpphhhDshhss.....Pstsas	............................t................................................................t..........a.....p....lp.....h..h..s..sDpAGN....p........s.s..p...t.h...t.h.h.h.cs................h........................	0	165	256	330
+12080	PF12246	MKT1_C		Temperature dependent protein affecting M2 dsRNA replication	Assefa S, Gavin OL	lg7	PFAM-B_2862 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.	19.40	19.40	20.60	20.40	18.50	16.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.29	0.70	-5.37	24	169	2009-08-07 15:47:53	2009-08-07 16:47:53	3	8	150	0	118	167	0	233.90	25	31.59	CHANGED	RhLpLhGals..........cppphTtaGcsLtpsssh.............htEshllhlELlRhslLssp..............s....sshpss..sc-pphlhLlSRlholhplpppshsYpGPls+plLsF+shlphl+pslppLlEsllsshlhpGcssp......stsphtplstpLPFhhss.ssshGlhschaLpchhpptpsppps.p...h.hst.......................a.pssslpc-LspuhpFWcslhpsspplsppphhsts..........hphascAscalppth	...........RhLpLhG..als..........pppphTtaGpsL.pshp...stp..........hpEshhlhlELlRhslLssc.................................s....tss.hpss....s--pp.hlLlSRlholhpl........pp.....c......s.....hsYs.GPls+pLLsF+shlphlppsLRpLhEs..llsuhllsGcssR............................spschtplshp..LP.Fhtss.ssshGlhs+haLpch.p..p.tpsp..s.pt..ph..hh.tsp...........................a.ps..shppsl.chuhpFac.tlhpshpplsppth.stp...........t.appAspahpt...................................	0	42	69	102
+12081	PF12247	MKT1_N		Temperature dependent protein affecting M2 dsRNA replication	Assefa S, Gavin OL	lg7	PFAM-B_2862 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the N terminal region of MKT1.	19.40	19.40	30.80	29.30	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.99	0.72	-3.66	25	157	2009-08-07 15:51:14	2009-08-07 16:51:14	3	9	139	\N	111	153	0	88.80	33	11.26	CHANGED	PsDhH-llGp+LPtElYaYhStGLlusplhsslopG.lh-psP..Lsst.....ocpYR+Llt.cplt.l....+spslsLlsppL...s+haphKpIpshhWF	..PsDlH-llGp+LPpElYaYhSpGLlusclhsslosGplh..p...P.............Lsst....tSppYR+Llt.cslh.h....+spslsLLsp.L...pRaaphKpIphhhWa.................	1	36	64	96
+12082	PF12248	Methyltransf_FA		Farnesoic acid 0-methyl transferase	Assefa S, Gavin OL	lg7	PFAM-B_2872 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 110 amino acids in length.Farnesoic acid O-methyl transferase (FAMeT) is the enzyme that catalyses the formation of methyl farnesoate (MF) from farnesoic acid (FA) in the biosynthetic pathway of juvenile hormone (JH).	21.40	21.40	21.70	21.50	20.90	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.15	0.72	-4.00	23	286	2009-08-07 15:52:06	2009-08-07 16:52:06	3	50	107	0	180	312	1	98.80	28	18.05	CHANGED	HltLoss.......hPh-ss.hhEIVlGuapNTtSsIRppht........ssslscspoPslL.sshc.phahlp.apsGplpVsps...G.cstPFlpap..Dsp.....thslpYhuF.osWssssha	....................ltLoss........sp-..ssshhElhlGGapNspSsIRpsp..................................spslsp.s.pTssl.l.s.spEh+pFWIs..hpsGhlpVGps.....u...c..t.pshhpap..-sp.....shsl.pahGh.ouWss.s...............................................................	0	77	104	162
+12083	PF12249	AftA_C		Arabinofuranosyltransferase A C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2900 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 179 and 190 amino acids in length. This family is the C terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The C terminal region is predicted to be directed towards the periplasm.	25.00	25.00	86.80	86.20	19.80	18.60	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.08	0.71	-4.85	9	161	2009-08-07 15:52:31	2009-08-07 16:52:31	3	2	159	0	34	126	0	178.10	55	27.40	CHANGED	sIPcsLcssIslAYTD..TDGpGpRAD+cPPuAspYYsplDcslpcpTG+sRscTVVLTsDhoFLSaYPYaGFQuhTSHYANPLA-FspRAstI-.....sWSpLpssschlAALcpsP....WpsPssFlhRpuu....ps.....uaTlcLApDlYPNpPNVRcYsVpFssulF..-sPtFslpplGPFVls.sRp	.....................DIP-hLps-lslAYTD..TDG.GpRuDRRPPGuppYYspIDtsIpchT.G.+.tccTVVLTADauFLSYYPYaGFQuLTSHYANPLApF-cRAspI-.....SW.....up...L...p...os--FltALDphP....WpsPsVFlhRtuu....ps......................uYoLRLApDVYPNpPNVRRYsVphssslF..sDP+.FsVpp..lGPFVlslRp.......	0	6	22	31
+12084	PF12250	AftA_N		Arabinofuranosyltransferase N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2900 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 430 and 441 amino acids in length. This family is the N terminal region of AftA. The enzyme catalyses the addition of the first key arabinofuranosyl residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol to the galactan domain of the cell wall, thus priming the galactan for further elaboration by the arabinofuranosyltransferases. The N terminal region has been predicted to span 11 transmembrane regions.	22.80	22.80	116.60	36.00	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.58	0.70	-5.76	5	168	2009-08-07 15:53:10	2009-08-07 16:53:10	3	3	160	0	37	136	0	421.50	50	67.31	CHANGED	LGQMllulVVAulVAsVuLhAIARVEWPAFNSSNQLHALTTVGQVuCLAGLsuuGLLWR+..G....R.R...plARLGohshlSAFoVVTLGMPLGATKLYLFGISVDQQFRTEYLTRLTDTAGLRDMTYIGLPPFYPAGWFWLGGRlAALTGTPAWEMFKPWAIlSIAIAlsVALVLWusMI.RFEYALVVolATTAlsLAYuSsEPYAAlITVLlPPsLVLAWuGLuu....pcpGGWAAVVGsGlFLGlAAoFYTLLlAYAAFTlslMALLlAuu.......hRRuaDPLlRLlVIAVlSGAIALlTWuPYLLtAhRGsPA-SGTAQHYLPc-GAcLsFPMlpFSLlGALChLGTlWLVsRARoSsRAGALAVGVlAVYLWSLLSMLsTLuGTTLLSFRLQPTLTVLLuAAGAFGFVEssts.....lutRhps..uRRVlusAsAVGAlGAl	.....................................htlssAlllAssVulVuhhAlspVpWPAFsoSN.h+ALTTVGQlssL..sslsuhshlW++..s..............................R..R......hLspl.suhlhsuu...hsVsTLGhPLuATKLYLaGISVDQpFRTpYLTRLTDosuLpDMoYlsLPPFYPsGWFWlGGRhAsLhGhPuWEhFKPWAIhSlAlAsslulsLWtRhl.phchAhhlslATs.AlsLsauusEPYAA.lIs.lh...lPPhLV....LshpuLpu............................ttuWuAllGsGlFLGhuAoaYTLhsAhsAholllhAlllAuh.......................hct..u..h..cP.L........h.....RLsVlGsluhAIAhhsWhPYLltshps.s.susouoApHYLPs-GAtLshPMlphSllGslCLlGhlWLVhRu+sss.AsALulGVlulYLWsLLSMlsTLutTTLLuFRLpPsLolLLssAGshGhsEhsts.......hstp.......uR...t..lh.shsusl.uhhGul...............................	0	6	23	34
+12085	PF12251	zf-SNAP50_C		snRNA-activating protein of 50kDa MW C terminal	Assefa S, Gavin OL	lg7	PFAM-B_2919 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 196 and 207 amino acids in length. There is a conserved CEH sequence motif. SNAP50 is part of the snRNA-activating protein complex which activates RNA polymerases II and III. There is a cysteine-histidine cluster which contains two possible zinc finger motifs.	23.30	23.30	23.30	25.70	23.10	23.20	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.89	0.71	-11.46	0.71	-4.93	20	210	2009-08-07 15:54:04	2009-08-07 16:54:04	3	7	163	0	144	212	4	183.30	30	46.58	CHANGED	tpcahlLuoQsLs-L+DshhChsstph.h..............spsphpuuaFFIcGsFYsDhR.....sscshDhSpsIhpa......sppps.............shuc.hpstpM-csphsDLplplGpPhhahHQGsCEHhllhoslRllsptc...shccstYPhhshcsphppptC.hC+httAphllhs.sphtscsPuahCssCFcha+asssGccls......pFpsatYhcc	...............................................................................h.tphhlLusQpLs-L+Dtl.C.s-h.h................................................................hstphhpSuaFalcssF..Y..sDhR................spshDhSpsIhcW......tpppp............................................thsp..hp.....st..pMcps..pasDL.p.l+l..G...P..YlYhHQ.............GsCEHhllhsDl..R...h.......hp.pc.............s.s........pt.YPhhh..h.p.........h.t.tppC.lCphh.A...phls.s.cphtspsPsahCc.Cachh+hs.tpGphlh......pa.sh.h....................................................................	0	62	85	120
+12086	PF12252	SidE		Dot/Icm substrate protein	Assefa S, Gavin OL	lg7	PFAM-B_2926 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 397 and 1543 amino acids in length. This family is the SidE protein in the Dot/Icm pathway of Legionella pneumophila bacteria. There is little literature describing the family.	18.50	18.50	18.50	18.50	18.40	18.20	hmmbuild  -o /dev/null HMM SEED	1439	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.27	0.69	-14.42	0.69	-7.26	7	111	2009-08-07 15:56:26	2009-08-07 16:56:26	3	4	15	0	19	89	0	795.40	33	87.88	CHANGED	MPKYVEGVELTQEGMHAIFsRMGHusIoSGoIYNG.PTIDptALspQGFMPVLTGVGP+pDSGHWIMLIKGPGNQYYLFDPLGKoSGEGYQNILAsQLPhGSTLSVIPNsssLNhGLCGYWVASVGLRA+AtLNpcsPPsLhNLGQTITsEMRNELscDGYcKITsWLRAVuDEFP...cGDsQP.DAKALREsTEKs.L+I-IPs.V.PsKDpoPKElslcPTsPQ.s.VPsWNGFSLaTD-sV+sAApYAYDNYLGKPYTGsVEusPAshGGph........h..RQpHGLAHTLRTMAYAElIVEEARKAKLRGETLtKFKDGRTlADVTPEELKKIMIAQAFFVsGRDDEtSstcp......YtKYHEQSRDAFLKYVcDNcSsLIPDlFKDpc-VsFYApVIEDKsHDWsuoPAHVLINQGHMVDLVRVKQPPESaLEpYFsohpsWIGopAsEAVFuhQRQFFHATaEVVsGF......DS-NpEPHLVVsGLtRYVIGEDGpPIREt.cpupK..cG-LKsFsQsYKLK-NERFMRVDEaLKLPEVQpTFPGuGK+LEGGhPGhs.hsYapRLNShpRARCENDVsFCLtQLQpAHcKsKIDPIKpAFQSSpcKsRRQPNhDEIAAApIIQQIhANPDCIHDDHVLINGQKLEEpFFRDLLAKC-MAVVGSLLNDTDItNIDTLMRHEKDTEFHSTsscAVPVK.IG-tW..cpRIpspusslT...QhKHDLIFLMQNDAWYFSRVNAIAQNRDKGSoFKEVLITsLMTPLTsKuLhDTS+u.........sPp+LaRGL.sLsEEFsptLINQANshIANTTppLFTDhSsEAFKQIKLNDhSphSuRTsASTTTshpLspphWs.....SNVIFEMLDPDGLLHPKQVGpHssGoEsEFSVYLPEDVALVPlKVThD.GKTppGcsRalFThVAVKSPDFIPRHESGYAVEPFLRMQssKLsElpsuIEK..sp.t..................PphEsIFs.LQscluh.ph.sclSstYKsFLpppVsPVLEpCLsulhpsssshLsKALAsFPoDpQWSAFN.sEAhpAKtQMDAlKQMltpKVVL-.....ALTQCQ-ALEKQNIsGAL-ALKpIPuEKEhup...IupELREQIQus+Q-....LESLQRAssTPlVoDccKV+.RY-sLIpssoK+lT-LEKupLssLDslKKuIusLsNLpQElTlLRNEKlRMHosoDK.VDFSDIEpLEpQlQ.lcTKLsDAYLlplTKplSAL-p.hPKs.o..-lKohlupFhshhs-IEhLRNERIKKHGuSKDPLDhSDLDKLpGpLQtlNQSLVssLlpsIRsSlsQMc.spTFchQcctIppNh-hLscLEKoLDcScsucK.+EDlsKLpsLLlsKQ.KAYPpMlQLQh+SEshIpQLRElCpsHaDsLsKsRpARLQEL-+...puGI...lGNlhasl...TshlGLTsDEpl-I+hKpQoLARFKs-LhNDK.DhDpLIspLAcKpPSELQEuLGISc-	.........................................................................................................................................................................................................................................................................D..VhtshpYsapphLtpsYs..Gs.....h..c.t..ss....t...t.h..........................R..HGLuHThRThhhuplhhEtu+.........tthtsGpolADlo.p-l+Kl.IAQhFFVsGR-sEtS.hs....................YtcYH..utptF.cYsccp.....sclFp.pc-lphYuthI.Dc.tp.atsostt.hLlp.uHMlDLhRsKtP.Eshlt.........h.ph...hG..ss.slhthtRthFhAThtsVs.h......ssp.........sa.s..s................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pp.p...p.Ll.th.pplh..tp.t....t..pp.h.........................................................................................................................................................................................................................................................................................................................................................................................................................	0	8	8	19
+12087	PF12253	CAF1A	CAF1B;	Chromatin assembly factor 1 subunit A	Wood V, Coggill P	pcc	manual	Family	The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A [1]. The A domain is uniquely required for the progression of S phase in mouse cells [2], independent of its ability to promote histone deposition [1] but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints [2].	21.20	20.90	21.30	20.90	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.90	0.72	-3.86	32	308	2009-08-11 15:32:32	2009-08-11 16:32:32	3	13	258	0	216	310	1	80.70	39	11.05	CHANGED	hKhlpFtEssRPPYhGTao+..........hh.h..+sPhppchsshDY-YDSDtEW.....EE..-E-G...E...-l...-.s........----.....---...-.-...p--...........-hDs..F	........................KhLpF..p.EshRPsYaG..Tas+................p...sthlhsRsPhsp.....-.......s....lDY......-hDSDtEW.....EE......-.E.G...E.....sl.c.s........--.--.....-.--......c..-....s--.......-.Ds..........................................	0	70	115	177
+12088	PF12254	DNA_pol_alpha_N		DNA polymerase alpha subunit p180 N terminal	Assefa S, Gavin OL	lg7	PFAM-B_2966 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00136, Pfam:PF08996, Pfam:PF03104. This family is the N terminal of DNA polymerase alpha subunit p180 protein. The N terminal contains the catalytic region of the alpha subunit.	20.60	20.60	21.30	20.60	19.80	20.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.36	0.72	-4.16	37	311	2009-08-11 15:36:44	2009-08-11 16:36:44	3	14	261	0	202	307	3	65.20	42	4.65	CHANGED	LpcL+thRputppttsth..csc...-tp...pIYDEVDE--YcclhcpRhtp.DDFlVDD...s...G.GYsDpGt--.W-c	................................LtpL+thRputpppt.ph.........-V-......-.p...slY-EVDE-pYp+lVcpR.pp.DDFlVDD..................s...G..GYsDDGcE..a-..............	0	61	103	161
+12089	PF12255	TcdB_toxin_midC		Insecticide toxin TcdB middle/C-terminal region	Assefa S, Gavin OL	lg7	PFAM-B_3032 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 150 amino acids in length. The family is found in association with Pfam:PF03534. This family is the C-terminal-sided middle region of the bacterial insecticide toxin TcdB.	25.00	25.00	29.90	28.90	23.60	22.50	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.77	0.71	-4.54	22	147	2009-08-11 15:37:11	2009-08-11 16:37:11	3	14	112	0	49	132	6	142.80	38	8.34	CHANGED	hhtRALKGplLRoElYGhDso.........tptshPYoVopsRhpVR.lpstss..p..slhhshslEshoapYE.RlssDPpsspplsLpsDpaGpsLcolslsYPRRspst.........s.a....ss.hspthhss..ShD-pQptL+lstsppohpHlspsps.......hhLGLP	.....htRALKGplLRoElYGLDso.........p.sshPYoVspsRYpVR.lQssss.....p......................s...VhhshslEploYpYE......R.ls............sD.PpsspplsLpsDpYGpsL+oVsIsYPRRspss.........ssa.....s.hspthhssphDppQptl+lspppppahp..ssp.....ahLGLP................................	0	15	27	41
+12090	PF12256	TcdB_toxin_midN		Insecticide toxin TcdB middle/N-terminal region	Assefa S, Gavin OL	lg7	PFAM-B_3032 (release 23.0)	Family	This domain family is found in bacteria and archaea, and is typically between 164 and 180 amino acids in length. The family is found in association with Pfam:PF05593. This family is the N-terminal-sided middle region of the bacterial insecticide toxin TcdB. This region appears related to the FG-GAP repeat Pfam:PF01839.	24.80	24.80	24.80	25.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.20	0.71	-4.82	29	294	2012-10-05 17:30:43	2009-08-11 16:37:22	3	55	209	0	101	298	21	169.80	24	8.84	CHANGED	spsGstau..pshplshPsssphs.t.pplphADlpG.Ghsslll.ohsth..........ts...tpahhthstt......p....PhLLsslsNshGspsplpYt....oSsphhLc-ptt.t.t....ssspLPhshpllpchshpDtl....s.Gsp...hsppapYppGhaDshEREFpGFuplpppDssss...................ssh.spsaatTG	......................................................................................................hs.hht.s......phplsDlpGpGhssllh...sssp.............p.......phhhh.shsss...............................+PhLLsslssshGupsplpYc............................s.Ssph....h..hs.-p....tt.tt...........................sspLPh.s.lpllsp.......s.pp..p.Dtl...........s..Gss.........hsppapYpp.G..haDstpR.-FhGFupVpppDhsst...........................psssh.spphah.....................................................................	0	40	59	86
+12091	PF12257	DUF3608		Protein of unknown function (DUF3608)	Assefa S, Gavin OL	lg7	PFAM-B_3083 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with Pfam:PF00610.	25.00	25.00	25.30	25.30	23.20	24.10	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.71	0.70	-5.50	9	344	2009-08-11 15:40:12	2009-08-11 16:40:12	3	8	247	0	223	351	9	242.40	40	18.31	CHANGED	VElalKDs.LsRssMWshSopLlsoCVahspRlsaLsshpusVKuIY+NGKKlhSGYIs-NTKIlFRSESA+llFllQlocEMWHFEEsGEhhFHKlVNSLFPKIF++W+-hsTHHoITIVhhsSlDhos.sassLs.GER.pNpcDYFRlVVDQVslhaW-cIMtsLRhEFhphp+Dlh.pp....pDssthshcGphhPslKuNlLEsINluhTllsD.F+ssDL+HTssHlIlloPGoGLaDV-YDLLh.To+KhhSl-hulDlICLSpPPLHlVPLFRY	..................................................................VElsh+DpalsRuDMWRl.t.p.p.LsspssYhs..p+l.......a.h....s...l+.sps.......t.pla..h...p.....s.........c.+V........h........sGah.s.ppT+.lFRSpSA..hhhlFIQ.........hSpEMW-....F.........-......................G................-lhFpK...slNuFLsc.LF.........p+Wtphs.....s..p..H.lT.lVL.....F.......s........p...h.....t...........................s...................t.............................t.............h........t.........p.........l.........t.......................s...................p.........t..........p.................h........c........DFY+V.V.Vp..p.t.p..t...cW.s...s.lLhpl++.F.hpa..h.............lhh..........p.............................................................................................h......t......ups.......Ss.....u.h.....p.GNhLEAl..........Nluhs....hhsccalsRshsRTGp..l..VITPGsGlF..-V....D.hpLh....hlTpp+hl.sp.Gl.G.lDLlChuc.PLHsVPLF+a..............................	0	86	125	187
+12092	PF12258	Microcephalin		Microcephalin protein	Assefa S, Gavin OL	lg7	PFAM-B_3105 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 384 and 835 amino acids in length. Microcephalin is involved in determining the size of the brain in animals. It is a protein, which if expressed homozygously causes the organism to have the condition microcephaly. Organisms expressing the mutated form of this protein in a homozygous manner develop a condition called microcephaly - a drastically reduced brain mass and volume. Microcephalin is predicted to contain three BRCA1 C-terminal domains, the first of which is the probable microcephaly mutation site.	25.00	25.00	26.10	26.10	19.30	19.20	hmmbuild  -o /dev/null HMM SEED	391	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.34	0.70	-5.48	6	148	2009-08-11 15:40:18	2009-08-11 16:40:18	3	5	90	0	19	138	0	368.30	56	71.39	CHANGED	ESFAuGLpSSFDDLCGtouCGsQEcKLtt.ls-hpoDsChSSPVLKsuSlaSSAussaLsQLoPQKssusLSKpElstQRDsAGclVTPDpKQutGlupEshDEKasLSPThSuoKs+.hsHSps+uSSAKRKRsu-hSpSuPcE+LK.KRspt+ushPplQLaKS-spLppsstsAscu.usttSSYDDYFSPDNLKERsSEsL.PtsQ.suuPAtFpC.RuLSKpERpsIL-MuDFSClGK+sRols.loslhAKosSSLpKPupscusAshuClhS.tTuAs--oPGsCsQAGs.tt-DspPtGsutspTh-s.Ahs.....cG.cGDloPLcGuSpEh+EssDs+STQKEGssscspsSutGEsQs-sc.uFusDsss-pSsp-KEslupGhSt	....-.FAGsLHSSFDDLCGsSGCGsQERKLGG.ls-hKSDsChSShVLKsssl+sSsS.saLsp.oPQKhhusLSKEElshQR.shAGclVTPDpKQAtshSptsF-EKhpLSPThSuTK.s+hhh+S.p...PpSSSsK......RKRVStsSpS.PPKE+hK+KRSlR+shhPRLQLh+SEsuhppsuusA.lEsLusGESSYDDYFSPDNLKERs...SEsL.Pt.sQ.Po.uPA.hpC.R.SLSK+ERTSlhEMuDFSClG+psRol-.hTs.hTAKohsS..QKsuN..scucsshSsVTSccTsAsE-o.tsCtQAsspt+-DA.pP.tGssh.saTl-s.sh.............KGpcGDhTP.LcGS.cE....h....KEhlslKST.....Q.p.c.GTs.SKhsNSuEGE.....AQS-cc...sFlsDsshEpSsE.E+EsLPtG.........................	0	1	1	4
+12093	PF12259	DUF3609		Protein of unknown function (DUF3609)	Assefa S, Gavin OL	lg7	PFAM-B_3173 (release 23.0)	Family	This domain family is found in eukaryotes and viruses, and is typically between 348 and 360 amino acids in length.	24.10	24.10	24.30	25.60	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-12.01	0.70	-5.78	7	125	2009-08-11 15:40:30	2009-08-11 16:40:30	3	5	70	0	28	124	0	295.00	28	53.39	CHANGED	LthLGspL+popsAIhEAlhSAaQspLSPhVLolpQLptch..h.ucLspthtL.hpp.oISDIYplAols.stQhsNalVFpIpVPLlDsEpFNlYRLTPIPR.lsNGpIQLl-TETPYLGIsDHLDRYFPLQN..LDDClcLssERalCc.spITYGssDcohsCoLAAIRNpoSpsCThRpVpcpSlWT.hlAPNSWMVALoKELoLhGVCSs-cQEL+INGSGILoIpSDClVRSssVTLQGpspKthPS+puYASLQhssposccsshh-SFspLhpIlspLchpQcp.psltsh.hshlsVCPsllLIsLLlShsWhY+saRp+t.....sQpPh..Vssh.sspNcspTsshPLLEKpEl	.................................................................................lpcAl..sA.pp.s+Lsshllo.ppL.sch..l...s.cLs..................t..p.....s...h...+sl...h.h..lss.....sh.....h.pt....ss.plhF.IpVPLl-s..pp.FslY+lsPIP..p....hsNs.....p.........h.p..ll.sco..Y..lG........l..ssc..h..c..p..Yh.L..ps..hs..sChcls.p.cphlChps.p.lhassssssh...s...Cs..l.......t......hh..+.s.....p....s.....s.......psCs.l.R.t.sc..p.p.p.lahphss..sN.sWh.h.slsc.-lsLhss..Cu..s..p...p.....p...pl.p..l..s.GoG.lL..o.l..pssChl+.......ostss......lp...............................................................................................................................................................................................................h..........................................................................................................................	0	14	17	25
+12094	PF12260	PIP49_C		Protein-kinase domain of FAM69	Assefa S, Gavin OL, Coggill P	lg7	PFAM-B_3196 (release 23.0)	Family	This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localised to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.	25.20	25.20	25.20	25.40	25.10	24.90	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.47	0.71	-4.88	36	397	2012-10-02 22:05:25	2009-08-11 16:45:28	3	7	89	0	254	354	0	186.10	26	48.34	CHANGED	lWsLLp....ps.Eal...lh.lhpc.p.-...hhP+lLGsCGchassEplshsphht..................hpphhpssWtt+u+lAltLL-hl-cl.pps..p..hahCDlshpsFGls.schc...lp..hlDhcplhscsphcphlpp.ppCpp.....s........pDCsa.hDCh.o.tCsh.pppCssphh..psN..LthlCp.p.l......hshh..........................LpGs........Ps...plppc...LpchLppCsp.	............................................hasLh.....s.E.l.lh..h.p.pc.......hs+hlG.C......G....c....hh..ssphls..p.h........................................................h.ph.h.s.ss.Wpp+s.clAlpLl-hlcpl.tpsshs..hhhsDh.....s.....hcsFuls....sc....hc.....lhhhDhcplhscsp.pphlp..t.ppCps.....s.........................pDCsh...hsCh....u...h...C..s...ptpCss.sh..ppN..LhtsCp.h.l...hshh...............................L..ss........Ps......plppp...Lpp.lppCht.....................................................	0	58	79	148
+12095	PF12261	T_hemolysin		Thermostable hemolysin	Assefa S, Gavin OL	lg7	PFAM-B_3198 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 200 and 228 amino acids in length. T_hemolysin is a pore-forming toxin of bacteria, able to lyse erythrocytes from a number of mammalian species.	20.70	20.70	21.40	21.10	20.10	19.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.92	0.71	-4.73	33	192	2009-09-11 08:17:19	2009-08-11 16:45:50	3	2	185	0	57	157	33	174.30	36	83.54	CHANGED	hthhpsscstRpplEpFIpppatpsasAclppFhPtLLul....sspupl..hAssGhRhAsppsLFLEpYLDpPlEphluphhsts.lsRspllElGsLAoh.s.sGsuphlhhslsthLhspGhcWllFTuTctLpshhpRLGLpspsLusAcss+L.scssspWGoYYcppPpVhuuslsp.uhptL	............................h.hhtsscsphscs.phlcpcYppsasAclptaMPshLuL....hs.cst...h..tussGhRh.A....p....p.pPLFLEQYLDpPs-pllupthups.lsRspllEhGpLASh.u..pGhu...thhFhhhsphLsshGa-WslFTATcsL+shhp.RhGLp.phlApAsssRl.ssssphWGoYYpppPplhAGsLspGhpt.h............	0	13	26	43
+12096	PF12262	Lipase_bact_N		Bacterial virulence factor lipase N-terminal	Assefa S	lg7	PFAM-B_3205 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 258 and 271 amino acids in length. There are two conserved sequence motifs: DGT and DGWST. This family is the N-terminal region of bacterial virulence factor lipase. The N-terminal region contains a potential signalling sequence.	20.10	20.10	20.20	20.10	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.89	0.70	-5.17	8	221	2009-08-11 15:51:27	2009-08-11 16:51:27	3	6	188	0	50	183	24	250.40	33	33.22	CHANGED	MK+p.hhhhllsSALhLuGCGD-opooGssTpss...pltpuLptETpIsFsLpu..ussslshPoYLhMDspDGTLpls...os..sssuloNPcsAMGphDGWSTo.PIslsF..pGssLssushsuulhlIKloschT....D.toss.p.lLs.ssDaslssoGsS..LhIlhLKsLssSSpYIFAVTsclpDhNGsPVGTSsSYAsLKSsshs.ssuuLsssQKVTQuoEulFutu...GVspssIVYSoWFoTQSlGDsLaAsKusTAsul..us...phssVW	.............................................MKph.lhhshlsS..AlhLuGCG.s....pos.s.p.usssp..........t..l..t..op.lpFshtu.....tsup....lPlPs.hLh....s...sp...DG....T...LplP..........ss.........sss..s.......h.sNP.h.sA.hu..t..l..DGWus.o.hP..l.l..sh................pG....s......sL...s......ss....h..............h....s....u......u.....lhlhE..l.o...s.hs........................ss..s....s..lt........t......h.......Ls.G...sD.as.......s.s.u....Su.ss........lh.IhPhKsLssuSpYlhAlTsp....lpDusG.pslusSsoYuslK..s..c............sh.....h..p..pu.......s....t...slQ.tlsp.u....hEp.l....h.t.hu..............uV.s.p..spIlYSsaFoTQS.lussLh..As+ushAssh..........................................................................	1	14	24	39
+12097	PF12263	DUF3611		Protein of unknown function (DUF3611)	Assefa S, Gavin OL	lg7	PFAM-B_3207 (release 23.0)	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 180 and 205 amino acids in length. There are two completely conserved residues (W and G) that may be functionally important.	24.90	24.90	25.20	25.00	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.13	0.71	-4.89	21	164	2009-08-11 15:51:34	2009-08-11 16:51:34	3	4	109	0	74	156	131	175.60	31	80.30	CHANGED	ssss.slp+hApslRhhGWIuFWhQlVLulVou.llLlFuslhsspstsspps.Gh...s.GlhhshhullsLhhSlahuatYsRlucpLp.t..ssstpPs+u-ss+hl+hGLllsLlGhhhullGhpAhsGhLluKulo.pssGh.....shssssphlp.uLDlhllhANssslhAHFlGllsSLWLLpplpp	................plpphutth+phGhluFWhQllLulVuuslLhFu.s...h.hsspsss...............st...........s.................s.ulhhsssGllslhhSlahuatY.hRlucpLp...ts..ssst.p.P...s+u-sh.+hl+hGlllNllGhhhullGhpAhlGsLluKulo..pssuh............shssssp..lp.uLDlhlV..AsssslhuHFlGllhSLaLLppl.........................	0	18	50	69
+12098	PF12264	Waikav_capsid_1	VSL_protease; Peptidase_C03;	Waikavirus capsid protein 1	Assefa S, Gavin OL, Eberhardt R	lg7	PFAM-B_3208 (release 23.0)	Family	The rice tungro spherical waikavirus polyprotein is cleaved into 7 proteins, including three capsid proteins, by the tungro spherical virus-type peptidase Pfam:PF12381. This family represents the capsid protein 1 [1,2].	24.40	24.40	25.50	80.00	24.30	23.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.29	0.71	-5.02	3	54	2009-08-11 15:52:48	2009-08-11 16:52:48	3	5	5	0	0	49	0	192.40	90	27.27	CHANGED	pEAFQDsEsRssDPNhSDMaNAlpuEYLVKSFoWKVSDGQDKVLuslsLPpDLWsoNSRLsDIMSYFQYYcATGlTFRITTTCIPMHGGTLhAAWDAsGCATRQGIATsVQLTGLPuhhIEAHSSSlTTloVcsPsIQSsICLSGSEHSFGRlGILKICCLNVLNAPpAATQpVuVNVWVKFDGVKFHaYSL+KsPV	.QEAHQDSSVAAAGP..TDEHNAMLQKIYLGSFKWKVSDGGGSILKTFSLPSDIWAANDRMKNFLSYFQYYTCEGMTFTLTITSIGLHGGTLLVAWDALSSATRRGIVSMIQLSNLPSMTLHASGSSIGTLTVTSPAIQHQICTSGSEGSIANLGSLVISVANVLCADSASAQELNVNAWVQFDKPKLSYWTAQHoI..	0	0	0	0
+12099	PF12265	CAF1C_H4-bd		Histone-binding protein RBBP4 or subunit C of CAF1 complex	Wood V, Coggill P	pcc	Pfam-B_318 (release 23.0)	Family	The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six [1].	22.70	22.70	23.80	23.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.65	0.72	-4.08	93	1002	2009-08-11 15:53:19	2009-08-11 16:53:19	3	13	342	12	648	938	11	71.70	33	16.24	CHANGED	p-chc.lWp....cssshlY-hlhstslpWPoLohcalPDth........sssp........tsppllhGTps......ss.......ppNhlhlhclphssp	.................EcaclW+....cssPhlYDhl.hspsLpWP.oLospalPDhp.....................sspt...........t...tsphLllGTpT.....ust..........cpNpLhlhplph.p.p............................	0	212	360	531
+12100	PF12266	DUF3613		Protein of unknown function (DUF3613)	Assefa S, Gavin OL	lg7	PFAM-B_3240 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 126 amino acids in length.	25.00	25.00	25.10	25.10	24.90	22.80	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.34	0.72	-4.46	18	138	2009-08-11 15:54:42	2009-08-11 16:54:42	3	1	135	0	44	132	2	67.80	34	59.51	CHANGED	Asps........ssuuc.hscuTcuWLtLQuss+AAu.ssQshsusptsLuhQRYL-SaKacIP-.haspptu	.........................ss..........ssssssp.hscuTcshLslQuS.G+tAu.ssQPhpGspusLuYQRYL-SFcpcIP-.aatpt..h......	0	6	15	29
+12101	PF12267	DUF3614		Protein of unknown function (DUF3614)	Assefa S, Gavin OL	lg7	PFAM-B_3244 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 162 and 495 amino acids in length.	25.00	25.00	35.60	35.50	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.03	0.71	-3.98	7	151	2009-08-11 15:54:47	2009-08-11 16:54:47	3	3	3	0	0	100	0	156.20	75	20.85	CHANGED	sFsuRhP......+ht+chsAohhcsuhuhVspuph....s.sps.shhp+Scsu....phP.sphssspsssAh.uss...VchsssSsssss...Rts.S.Pps........l+sush.lsVuuss+c.hsKlR-shhp.phGt.hpFS.F.SuT.....VhNsRssppsah...................hVhhLR.souupF.hlLh	...hsuRhP......RYEHHYDASMKGAGLSWVRKSQF....PNVEV.IRRRRSRASGSSASFPDANLQVSSDRP...SES...VQVVPMLDEGSSPP.RGVsS..PRR......DPVEGSGW.YSVGSPSR+.SSTsRGQRSA.ERGKIGDFS.FPSGT.....VYNARVDERAYK...................RVLKLRDTSASSFLRIV...	0	0	0	0
+12102	PF12268	DUF3612		Protein of unknown function (DUF3612)	Assefa S, Gavin OL	lg7	PFAM-B_3220 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 180 amino acids in length. The family is found in association with Pfam:PF01381.	25.00	25.00	91.20	91.00	20.00	16.80	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.28	0.71	-4.49	6	144	2009-08-11 15:56:56	2009-08-11 16:56:56	3	6	142	0	29	92	29	177.60	80	36.16	CHANGED	TsVSPYPHWHYFDAYuPGKLKAVYRGNGIPLPWGNMRtVcDPCQHWAVFRMIupsssGSSAQISILsVuspPRIYCCESIKVpD.AGNsHVLCAGIDLNPAI-AQGsDAlulAcpLKshCVusGGSusIPppIKp-LhSlA+ILNINWIERGIpspARLICSRGAVCPRpPSCYt....sCs	...TVVSPYPHWHYFDAYG.GKLKAVYRGNGIPLPWGNMRKVNDPCQHWAVFRRLSpPp....pGSSAQISILsVGDEPRIYCCESlNVhDPAGNNRVLCAGIDLNPAIsAQGGDALuIApELKhuCVppGGoosIPtsIK+DLpTIAKILNINWlERGI-s-ARLICSRGAVCPRpPpCYucC.G.....	0	4	9	21
+12103	PF12269	zf-CpG_bind_C		CpG binding protein zinc finger C terminal domain	Assefa S, Gavin OL	lg7	PFAM-B_3253 (release 23.0)	Domain	This domain family is found in eukaryotes, and is approximately 240 amino acids in length. This domain is the zinc finger domain of a CpG binding DNA methyltransferase protein. It contains a CxxC motif which forms the zinc finger and binds to DNA.	21.70	21.70	23.40	23.40	20.80	21.30	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.66	0.70	-4.88	6	134	2009-08-11 15:57:41	2009-08-11 16:57:41	3	9	86	0	79	130	0	213.60	55	40.04	CHANGED	AspRIhplLPQRlQpWshoPshAsEps+ctL-cIR++Qp.sRspLtELE++apcL-slIpRA+cpolspppsp......-ss-psD.-.sIaCVTCGHpIssRsAl+HMEKCatKhESQsSFGShaKTRI-G.ssLFCDhYNsQu+TYCKRLRVLCPEHoK-PKlPsT-VCGCPLVpNVFE.T.....G-FCRAPK+pChKHYsWEKlRRAEIDLERVRQWlKhDELhEQERtl+pAhosRAGlLGLh	.........................................................................................................................AssRIaplLPQRIQpWp.o.PClAEEps++hLE.cIR+cQptsRhcLp-hE+RacEL-slI.+AKpptlp..pp.c-s......s-s-.scD...s-hplaCloCGH.slss+sAl+...HME+CasKYESQsSFGSha.TRIEG..splFCDhYNPpSKTYCKRLpVLCPEHo+DPKV.........s.s.sEVCGCPLV....p...s....V.....F-hT.................G-FCRhsK+pCs+HYsWEKLRRAElDLERVR...hWhKLDELhEQERslRpAMosRAGLLuLM.............	0	27	32	57
+12104	PF12270	Cyt_c_ox_IV		Cytochrome c oxidase subunit IV	Assefa S, Gavin OL	lg7	PFAM-B_3280 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. This family is the fourth subunit of the cytochrome c oxidase complex. This subunit does not have a catalytic capacity but instead, is required for assembly and/or stability of the complex.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.94	0.71	-4.42	24	381	2009-08-11 15:57:58	2009-08-11 16:57:58	3	3	366	0	107	227	117	134.00	43	95.16	CHANGED	M+spu+lFhhlssFFhhsullYshhoth..........EWsGosALhLusuLuhhlGsYLthsuRRl....shtPEDpp-AEIsDGAG-lGFFSPtSaWPlhlAsusulsslGlA.hhh.WllhlGsshllhulsGhlFEYapGscp+	.....................MKhEu+lFthluhFallsullYhhhop...................EhAGTsuLsLouuhuLhluhYlpFsA+Rl.....-sRPED.c-AElsDGAGplGFFSPpShWPlhhAlusAlhslGls.hhh....WLhhlGls.h.llhussGhsFEYahGsptH........	1	34	84	102
+12105	PF12271	Chs3p		Chitin synthase III catalytic subunit	Assefa S, Gavin OL	lg7	PFAM-B_3298 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 288 and 332 amino acids in length. This family is the catalytic domain of chitin synthase III. Chitin is a major component of fungal cell walls and this enzyme is responsible for its formation.	25.10	25.10	35.60	35.00	23.80	23.40	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.81	0.70	-5.44	15	224	2009-08-11 15:59:44	2009-08-11 16:59:44	3	4	136	0	173	213	0	274.80	39	90.17	CHANGED	MsFGsFsoICccAuLPLCulVGs.s.p.ssspGIhPsCYuRsIELANTh.IFQhusshlHlsALlholIhIl+VRuKaTAVGR+ElloFFYlYhhLplsSLllDuGVsPPuSssasYFsAVQhGlsSAlChCLLlNGhVGFQLaEDGTslSlWhLRlsShlhFlloFhIuLsTFKuWsG......LusspTlGLFVlhYllNAlhLslYlVhQllLVlpsLp-pWPLGtIuhGlFFFlAGQVlhYsFSssICcussHYlDGLFFATlCNLLAVMMlYKaWDSITc-DLEFSVGshpssa	...........................tFGsFpshCpc.....s.....sLPlCsll.............ss........t.................................................t......t......................Gh.ssChhR........sIplus.sh...lhphushhlphhAlhhsllhlh+scpKhsAV.GR.......+EhhhFhhhYhllplhplhlsuGl.P.suusshsaFsAlphGhhuAsshsLLlNGhVGFQ..lhEDGTslSlhLlphouhshFlsohhluLsThh.uWsG..........husspsluLaVlhhllshlhLhlYhlhQllLVlpsLp-hWPhu......tlshushhFshGQVhhYshSspICpusp+YlDGhFFuTlhsLLuVhMVYKaWcSITc-DhEhsVu....................	0	48	94	146
+12106	PF12272	DUF3610		Protein of unknown function (DUF3610)	Assefa S, Gavin OL	lg7	PFAM-B_3173 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 146 and 160 amino acids in length. There are two conserved sequence motifs: FNN and IDS.	25.00	25.00	55.00	50.50	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-4.57	10	53	2009-08-11 16:00:08	2009-08-11 17:00:08	3	2	17	0	4	53	0	156.20	59	30.09	CHANGED	MpupohhFlLlslLI...uLSHuosVcp-css..uPMuM+GFNNSLGTFVEYuGQASlAocDWplpsSFNL-SLhsuIpsFp..plYKsLhDhCchp.pshCP-hh..DlTcFADoILpDGLlcsccsL-a+.....ltRLS.u---hup.hpNsoSsIDSol..NllsVulhE	...MKAIuLsFILlPlLl...ALSHGSPVsR.-AIG..GPMAMRGFNNSLGTFVEYSGQASLAS+DWcLCASFNLESLYsAIhAFN..uVYKslVD.C-cQ.ps.CPEIh.....sITcFA-SILHDGLhDLEsALcaR..........................AGRLs.u.-.DDVupELtMuTSCIDSSI..NVINVuL........	0	1	1	2
+12107	PF12273	RCR		Chitin synthesis regulation, resistance to Congo red	Wood V, Coggill P	pcc	Pfam-B_2935 (release 23.0)	Family	RCR proteins are ER membrane proteins that regulate chitin deposition in fungal cell walls. Although chitin, a linear polymer of beta-1,4-linked N-acetylglucosamine, constitutes only 2% of the cell wall it plays a vital role in the overall protection of the cell wall against stress, noxious chemicals and osmotic pressure changes. Congo red is a cell wall-disrupting benzidine-type dye extensively used in many cell wall mutant studies that specifically targets chitin in yeast cells and inhibits growth. RCR proteins render the yeasts resistant to Congo red by diminishing the content of chitin in the cell wall [1]. RCR proteins are probably regulating chitin synthase III interact directly with ubiquitin ligase Rsp5, and the VPEY motif is necessary for this, via interaction with the WW domains of Rsp5 [2].	25.10	25.10	25.10	25.10	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.25	0.71	-3.59	29	193	2009-09-11 15:13:23	2009-08-12 12:50:30	3	4	119	0	142	179	1	129.30	23	66.82	CHANGED	RWlhaslhlhslllhhhhhhphNpRRR+p.GhpPhhGTuWhs...PPsY.tQppp................pYst............hsP..sttss.t.s.hGY.Yspputa.ss.p.................h.lt.P.psh........ths.tth..hts..............................PsGPP...P	................RWhhhslh.l.lshllllhhhhph.s+RR++....p...Gh...p.....PhhG..TuWhs........sPsa..tps..pp..........................pYsts.t..st...............thsPt.Ystsss...tts.......hGh.Yst.p.sphtsssps.................................ht.P.....ts.......................................................................................................................................	0	27	69	121
+12108	PF12274	DUF3615		Protein of unknown function (DUF3615)	Assefa S	lg7	PFAM-B_3306 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is typically between 86 and 97 amino acids in length. There is a conserved FAE sequence motif. There is a single completely conserved residue F that may be functionally important.	21.00	21.00	21.90	21.00	20.90	20.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.74	0.72	-3.65	18	304	2009-08-12 14:43:54	2009-08-12 15:43:54	3	10	8	0	163	247	0	88.00	22	24.14	CHANGED	Yspsps.......shpY-Lhclhppshhh-ptth..apHhNFhupp+s...pt.shs.phFFAElc........stpsppVhsCs.lcsscs.....GpCauCtspsh....LcHP	...............................................t.thch.ph.ht..p..h..........p....p..tth.....a.tHlNFhApscs.............s......ss.........pLFFAElp.........................ptppt.th....hCs..lpssps.................stCh.hC..tt.....hhHP..........................................	0	0	25	96
+12109	PF12275	DUF3616		Protein of unknown function (DUF3616)	Assefa S, Gavin OL	lg7	PFAM-B_3338 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 335 and 392 amino acids in length. There is a conserved GLRGPV sequence motif.	20.60	20.60	22.80	21.50	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.12	0.70	-5.43	18	148	2009-08-12 14:49:12	2009-08-12 15:49:12	3	15	126	0	70	162	13	258.00	25	53.17	CHANGED	-hSusshssctpLWl.uuDEs.sslERLshhsss....hhssH.ppFsLu-hh-LPss..st.....EhDlEGL..Al.usGYLWlsGSHSlKRKss+spcsp.cshpcLuclph-sNRtlLuRlPl.spsssh.psspshcstp.......htAthlthpptt.s.LtphLusDPpLusFl...sIPuKDN..GFDIEGLAVps.p....RlhLGLRGPVLR.GaAlllElcsppssss..hLtLtshttpGp...hY+KHFLDLsGLGIRDL...phsGD.DLllLAGPTMc..L-Gsl+la+Wpssss...tp......tstlpphhsLPatpGsD+AEGlshhs......tsssplLlVYDSPstpRcss.ssslhuD	................................................................................uh....t..hhl.stD-...th.plh...t..........h..p....h.h.t...........tt.........DlEuh..sh..tt.......shlahhsSHu.p+pt.c....................p.sR..hlh.ph.l...t..............................................L.hphlttc..tht.hh...........thPs...ccs....G.hsIEGl..s..hss..p....plhlGhR....uP....l....h...............c....G.....hAh.ll.lps.t..ph.p...........htht.h................hchhhLcL.s.G....h.....GIR-l...phs..ss..chh.llAG.P....shs........s..Gs..hplapWsus.s.........t...........t........h.l.....s.......t.t......psEuls.h.......tt..phllh.Dts.......................................................................	0	20	49	63
+12110	PF12276	DUF3617		Protein of unknown function (DUF3617)	Assefa S, Gavin OL	lg7	PFAM-B_3343 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 179 amino acids in length. There is a single completely conserved residue C that may be functionally important.	20.70	20.70	21.00	21.10	20.00	20.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.24	0.71	-4.78	62	339	2009-08-12 14:49:20	2009-08-12 15:49:20	3	2	307	0	107	263	20	153.30	24	93.08	CHANGED	Mpphhhhhhhhhhh........................sssssssstpl.....csGLWEhsspht.........................................sth.....shptClotppsct.pt.........hspsppsCphpshppsusphshshsCsssth....ssspstssshssssassphshpsssst.t...hshphsh..pu+alG.sCt	.......................................................Mpphh.shhhsshh..........................huhssshA.sl.......................pPG..Wchpshph.....................................pth....t.shhs...........p...shssthChTsctscssct........hsssssuCops..hscp..o.ssplhhchsC...sssss...t..upuh..spssthSss..cFshshpusssusutt......tsst.ch..cupalG.sCs...........................	0	26	70	91
+12111	PF12277	DUF3618		Protein of unknown function (DUF3618)	Assefa S, Gavin OL	lg7	PFAM-B_3350 (release 23.0)	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length.	21.70	21.70	21.80	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-7.93	0.72	-3.93	61	612	2009-08-12 14:49:29	2009-08-12 15:49:29	3	6	483	0	202	459	7	48.20	30	32.03	CHANGED	hscs.ssplcp-I-psRscLupTlDpLss+hs.Pcplsccttsps+spssp	...........t+s.sspIcp-I-psRspLAsTl-pLsp+ss.Pppls....c-stspspshht.t.........................	0	71	147	182
+12112	PF12278	SDP_N		Sex determination protein N terminal	Assefa S, Gavin OL	lg7	PFAM-B_3366 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 410 amino acids in length. This family is the N terminal end of the sex determination protein of many different animals. It plays a role in the gender determination of around 20% of all animals.	25.00	25.00	34.60	34.40	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.22	0.71	-4.62	3	123	2009-08-12 14:53:08	2009-08-12 15:53:08	3	6	14	0	16	123	0	157.10	69	42.76	CHANGED	MKRNhSSYhHRDEKFKQLRSEDSESGLRSR...TEDERLQHRREEWhIQQEREREHEKLKKKMILEYELRRtREhchhLSKRS+TKSRSPESQDRNNAS..NTSKTlILFEKLESSDDTSLFRGPEGTQINATELRKIKl-IHRVLPGKPTTTTuEVKRDIINPEDVlLKRRT	....................MKRNhSsYSH+DE+F+QLRsE..DsE..h..sLRSR...TcEERLQHRREtWhIQQEREREHE+LpKKMILEYELRRt...R.....EhpK.......hh.......Sc.......R........S........KSRSP.-.sR.DRsN.s.S..NTSKThILS-KLE..SS..D.shS.LFRGP.EGhQINATELRKIKl-IHRsLPGKsT.......T.TTsElKRDIINPEDVhLpRRT.......	0	5	5	16
+12113	PF12279	DUF3619		Protein of unknown function (DUF3619)	Assefa S, Gavin OL	lg7	PFAM-B_3353 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are about 140 amino acids in length. This protein has two conserved sequence motifs: AAR and DDLP.	21.90	21.90	22.10	22.40	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.54	0.71	-4.07	24	136	2009-08-12 14:53:12	2009-08-12 15:53:12	3	1	134	0	61	127	16	128.70	42	91.66	CHANGED	hpEcca.A+clpttLccuss....sLPssls-R..LtAARptALup+Kspss...hhssthuhsGtuutsh............ttsahp+luhshPLhALl.s....GLlsIshapsppphsElA-lDAAlLoDDLPssAYhDpGFhtaLcps	............pEhcF.Ahcl+pALsEsuu....sLPssss-R..LAAARctALA++Ks-ss...lhss.....AhuGsuushh...........sp.tsuhh+RL...u.hshPLhsLl.s.....GLlGIshaps.pRs.sELA-lDAAhLoDDLPlsAYhDpGFstYLpp.s........................................	0	7	34	48
+12114	PF12280	BSMAP		Brain specific membrane anchored protein	Assefa S, Gavin OL	lg7	PFAM-B_3398 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 285 and 331 amino acids in length. BSMAP has a putative transmembrane domain and is predicted to be a type I membrane glycoprotein.	25.00	25.00	27.30	27.40	21.90	20.50	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.63	0.70	-4.44	11	161	2009-08-12 14:53:24	2009-08-12 15:53:24	3	2	62	0	76	147	0	172.00	43	59.27	CHANGED	RGCRLFSICQF.VscspchNsTchEC-uACpEAY.scssEQhACshGCtsQ...spsEh...cpcpLtuL.s+.t..LpslphVpsahsDlhsSAQsaI..oSoWTaYLQsDsGKlVVhQocsplphhs.........p.p..p...pt...pt.t.pss.ttshsphRs.u.p.+s...cpspsu.ht.p..t..tpsFLpChS.......+psGhspWlLsssLhLSVllhLWl	...............................................................RGCRLFSI..CpF..Vs.cu.chNpT+..hECEu.ACsEAY.sppsEQhACphGCtsQ.....P.sEh.............ppcplhsL..sp.+h.L.sLsLlpohhsDhhsSAQSFI..oSoWTaYLQADsGKlVlFQopPplphhs.........php....shpt............p......hh..sh.p.h+p..s.t.hRs...ctppps..................FLpChS.......hp...stWI......LsssLhLSVhVhLWl......................................................................................................................................................................................	0	14	18	38
+12115	PF12281	DUF3620		Protein of unknown function (DUF3620)	Assefa S, Gavin OL	lg7	PFAM-B_3384 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 281 and 358 amino acids in length. There are two completely conserved residues (G and P) that may be functionally important.	20.70	20.70	21.50	21.30	19.80	20.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.43	0.70	-4.62	29	119	2009-08-12 14:56:28	2009-08-12 15:56:28	3	5	97	0	66	129	4	203.20	28	62.83	CHANGED	sphsucllcAlupuGhFRhtuhllGTtAapsYsuhLGl+l.tssh.tTGDlDlAtt.tplSlsl...scshpsslhsl.Lps.h-hsFpslsphsttttsptpps....ahV-FLTspptssch.....st.hsuh.sssApsLcaLcaLlscP.lcslsltcsG.....lhVplPsPcpaAlHKLI.lus+Rp..tts.sKppKDhtQAshlhchl.spcpsppL.tp.uatcAhsR	................supllpslspsGhaRhtssllGThAatsYtshhGlch..s.sh.tTsDhDlA....phshtl.....tsph..slhpl.Lpp...t.sFc...lsphst.t..t...tspttps.........hhV-FLTsptussp...........p.h.ssh.sssApsLcaLs.aLltpP..lps.sh....ltcsG.....l.l...plPsPtpaAlHKLl.luscRp..t.s.hKptKDhtQAthlhchl.tpph.t...t.s.............................................................	0	23	43	52
+12116	PF12282	H_kinase_N		Signal transduction histidine kinase	Assefa S, Gavin OL	lg7	PFAM-B_3401 (release 23.0)	Family	This domain is found in bacteria. This domain is about 150 amino acids in length. This domain is found associated with Pfam:PF07568, Pfam:PF08448, Pfam:PF02518. This domain has a single completely conserved residue P that may be functionally important. This family is mostly annotated as a histidine kinase involved in signal transduction but there is little published evidence to support this.	22.90	22.90	25.00	23.00	22.10	20.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.45	0.71	-4.58	64	599	2009-08-17 12:16:09	2009-08-17 13:16:09	3	6	591	3	127	400	134	145.90	30	30.13	CHANGED	sLs-ll..tppTsLsss-l-aLcpllu-WQllADLoFADlllhl.........sscus.........hlsVApsRPsTusTsahsDl.VGphs...............tspcPtltcshpsGphsRstcsthtssh....slc....ppslPV+ps......s...cl...IAVls..cc..sslsss+psutLEhsahpsAs	...........lpclhtppTsLs-sDl-aLcplls-WQllADhuhADlllhV....................sccss..........hlsVAps.RP..s..TssolhpsDl.VGphs.....................................................htssc.PhVtcshpouthscs.tp...sthptsh....slc...pshPlppp..........s..cV.....IuVlh....pc....ssltstcpsuphEpsaht.....................................	0	48	97	117
+12117	PF12283	Protein_K		Bacteriophage protein K	Assefa S, Gavin OL	lg7	PFAM-B_3455 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are approximately 60 amino acids in length. This family is a protein expressed by bacteriophages which has an unknown function. There is evidence that it is non-essential for in vivo production of a mature phage.	25.00	25.00	78.10	78.00	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.72	0.72	-4.09	2	51	2009-08-18 10:28:34	2009-08-18 11:28:34	3	1	36	0	0	29	0	55.50	78	100.00	CHANGED	Mp.KhhLlhQELLLLsYELNRSGLLsENEcIps.LtpLEhlLLpsLSPSopcusKs	MSRKIhLIKQELLLLVYELNRSGLLsENEcIRsILApLE+lLLCcLSPSopcosKs.	0	0	0	0
+12118	PF12284	HoxA13_N		Hox protein A13 N terminal	Assefa S, Gavin OL	lg7	PFAM-B_3464 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 149 and 306 amino acids in length. The family is found in association with Pfam:PF00046. This family is the N terminal of the Hox gene protein involved in formation of the digital arch of the hands and feet as well as in correct genital formation. Mutation of the protein is associated with hand-foot-genital syndrome.	19.90	19.90	20.50	20.20	19.10	19.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.86	0.71	-3.95	12	395	2009-08-19 10:03:12	2009-08-19 11:03:12	3	4	191	0	88	358	0	114.00	42	47.88	CHANGED	hD-hsKNMEGFs.GGNF....uAsQCRNLhAHPssLAP..SusYsSSEV.ssuGhuEP.uKQCSPCS.AsQuSu.uASLPYGYF.GuGYYPCRMSHH....sulKSCAQ..s..uSa.u-KYMDTSso.GE-F.oSR	..................................................h..................s.ssh...........sAspC.RsLh.......uH......P.........u......s...hs.s...........u..u.....u......h.....s.....o.......u..p.............s...s.....s...s..u....h....................uE..........s....sKQC.....u..P..Cs...A.s.....Qu..SS...s.A......uLP...YGY..F...GuGYYsC.R.huHp.......sulKSC.uQ.............su...uua.u-KYMDTS....s....s.....s...uE-a.sSR.......................................	2	5	13	40
+12119	PF12285	DUF3621		Protein of unknown function (DUF3621)	Assefa S, Gavin OL	lg7	PFAM-B_3468 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 49 and 62 amino acids in length. There are two conserved sequence motifs: QPLDLS and EQQ.	25.00	25.00	30.70	30.70	24.60	16.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.60	0.72	-3.81	3	129	2009-08-19 10:07:37	2009-08-19 11:07:37	3	6	13	0	0	96	0	49.00	78	16.18	CHANGED	KPCPEPs......TEsQPLDLSQKKEKQoEHEQQVsKPlKsQKNEPQPYSQTYGK	......KssPEPE......sEuQPLDLSQKK.....EKQPEHEQQVVKPhKPQKsEPQPYSQTYGK.	0	0	0	0
+12120	PF12286	DUF3622		Protein of unknown function (DUF3622)	Assefa S, Gavin OL	lg7	PFAM-B_3490 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 72 and 107 amino acids in length. There is a conserved VSK sequence motif.	20.30	20.30	20.30	21.10	19.30	19.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.21	0.72	-3.67	15	92	2009-08-19 10:16:05	2009-08-19 11:16:05	3	1	91	0	24	68	4	70.60	58	53.13	CHANGED	MocsKKa-aRlsppcsuWsAEITR+lTuR+TlVSKpcsGFuoEAEApsWuEpELpuFLpN.tcRNcRKA-p	...MocsKKFshRlopc+sGWsAEIT..RphTSRKTlVSKRcsGFsTEAc....AQsWuEpELtuFlps.s.RNERKucp.................	0	2	7	16
+12121	PF12287	Caprin-1_C		Cytoplasmic activation/proliferation-associated protein-1 C term	Assefa S, Gavin OL	lg7	PFAM-B_3504 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteristic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.	25.00	25.00	25.80	25.80	20.60	19.40	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.29	0.70	-5.05	6	155	2009-08-19 10:17:39	2009-08-19 11:17:39	3	3	40	0	55	136	0	264.70	48	39.45	CHANGED	QGsYNFMQDSMLEF-GQsLDPAIVSAQPMKPsQsMDh.QMVCPPsHsESRLuQPsuVPVQPEsTQVPhVSsss-saoooPPlYQPSHTsEPRPQs-slD.IQASMSLsoEQoPssSSLPuAsQPQVh.....KPLHSSGINVNAAPFQSMQTVFNhNAPVPPsNEs-oLK.psQYQuSYuQuFSSQstHsVEQoElQpEQLQoVVGuFHopDQshppus....uuHQQPopQGsGFsRpuQSFYNSRG.MuRGGPRNsRGhlNGYRGsSNGFRGGYDGYRPPFuNTPNoGYG.QsQFST.PRDYSNssYQRDGYQ.NaKRGuGQGsR	....................................................................................................................................QGshNFhQ.............-ShL-F-p.s...........sAIs..SuQ..P.pss...............ssss......p.....tE..ppL.up.sph....p..s.psTp..ss.hsss.s..s...s.h.......s.ss..................h.ps................ocs..t..p...p...tt..s.......-..p..ss...h....s...spp..o....shuSs....P..sh.u..p...QsFQ..........pP...p.S.S.uls..lN..sA.PFQ.uMQT..VFNhNAPlPPhpE...Ehhc.ps.pYpuuYNQSFoo...........ts...........ppspQs..pL............p.....p.pl......Qo..s.....V.......ss.....hcs.....s.....ssp..p...ss....Gsht..PtQsssFPRssQPahNSRG.ssRGssRGuRulhNuYRuP..sGa+..tGaDuYRs.......shs.sss.Nus..Ys.Q.QFsA..R-YSu..Y.QRD..s.aQQsaKRGuspus.s..........................	0	3	7	19
+12122	PF12288	CsoS2_M		Carboxysome shell peptide mid-region	Assefa S, Gavin OL	lg7	PFAM-B_3507 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 430 amino acids in length. This family is annotated frequently as a carboxysome shell peptide, however there is little publication to confirm this.	20.00	20.00	21.10	20.00	16.80	19.90	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.81	0.70	-5.31	13	104	2009-08-19 10:28:48	2009-08-19 11:28:48	3	3	69	0	42	110	359	315.70	37	60.72	CHANGED	NsSRAlVLARREA.SK+GKoA.......upQsoouAuVARQuNPDlSSRElAQ+VRELRSKsGAs....ssppsGsoRPsGPNRs.....GuKQ.uuAuDAHWKVGtSETsoGQsVTGTQANR.ShKTTGNEASTCRoITGTEYLGAElFpoFCQ.SpPthtQPuKVsVTsTSHGN+VTG.NEVGRSEKVTGDEPGTCKslTGTEYISANQSssYCGs.sssSP+KVGpShTpsGppVSGVhVGRSp+VTGsEuGus+pLTGDQYLGu-P.s.sGRuspKVuShpTL+GsGVTGTsVGRo-pVTGsEsGSC+pVTGDEYIGuQQYcuFCus+PpPEAsKVGhSlTN+uQhVSGTpTGRSphVTGDEPGTCKAVTGTPYAGLEQuspaCsssulp-l+pRTPpphuTsu.sphTGlQPGIGGVMTGA-KGACEslTGTPYVGuDQhutAC	................................sR.hs..hRtA.stttt.t......................ths..........t.......t........h.ss+phu.t.hRt..s..Gt.......tt....s+Psu..+t..................................h..KVt.upT.tGphVTGTpspc.s.+sTGsEsuoCRslTGTEYhG..sE.hp.p.hCp.ttPt...tP...+..VtlotTsp..uppVoG.splGRSp+VTGDE.GsC+tlTGTEYluupp...hC....s..s......t.s.t.plh.s.ottsp...loGs..tps..........ttVTGsE.....Gs.spplTGspYht.............t................tup...s.....stK.Vu..pTlpGps...VTGT.Vu+usplTGsE.GuC+.VTGspYluspphpshC...ss.pP..s.p...stKVuhshT.csp.VoGTtsGRSttVTGsEsGsCpslTGTsYh.G..ppht..thCss....tt.t...h...t........h.oG..p..G.ss...hTGstpGtsp.loGo.Y.G.tt.....................................................	0	11	25	38
+12123	PF12289	Rotavirus_VP1		Rotavirus VP1 structural protein	Assefa S, Gavin OL	lg7	PFAM-B_3516 (release 23.0)	Family	This domain family is found in viruses, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF02123. VP1 is a structural protein of the inner core layer of the rotavirus virion. It complexes with VP2 and Vp3 to form this layer.	19.40	19.40	20.80	35.70	17.50	15.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.57	0.72	-4.34	2	470	2009-08-19 10:32:54	2009-08-19 11:32:54	3	2	231	10	0	377	0	51.00	94	5.17	CHANGED	ScGItlTEKAKLNSYAPlhLEKRRsQhShhlohLQpPsoFKSpp.lTINDlL	..SKGIAVTEKAKLNSYAPVYLEKRRAQISALLTMLQKPVSFKSNK.ITINDIL.	2	0	0	0
+12124	PF12290	DUF3802	topoisom_IIA_B; Topoisom_IIA_B;	Protein of unknown function (DUF3802)	Assefa S, Gavin OL	lg7	PFAM-B_3547 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 143 amino acids in length. There is a conserved KNLFD sequence motif.	20.80	20.80	21.00	94.70	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.39	0.71	-3.77	17	157	2009-12-04 10:35:14	2009-08-19 11:36:19	3	1	156	0	31	85	9	112.40	60	96.12	CHANGED	MVs-pDGYhpLIpYLT-pLuLFE.tspssssus-TVh-lhE-plAsplhhVCsQNspLshspR.hllRElDAIVhDLEElLuuVhsppsTsEQhtFIsEFsuLlKNLFDptluch	MVVETDGYLALIEHLo.NhslFs...ppGDTGsEoVEDVlTDMlASNIMuIFEQNPELHSSVRFpLLKEADuVVtDLGEVLAGVWt+sATNEQIuFLDEYIuLVKNLFDoAVAKY.	0	4	9	20
+12125	PF12291	DUF3623		Protein of unknown function (DUF3623)	Assefa S, Gavin OL	lg7	PFAM-B_3578 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 261 and 345 amino acids in length.	18.90	18.90	19.70	19.40	18.40	18.10	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.72	0.70	-5.42	30	93	2009-08-19 10:44:53	2009-08-19 11:44:53	3	4	86	0	33	90	126	256.20	37	85.67	CHANGED	MsshhlssLhAlFlWWFSTGllLhll+h.sc+....sathuhlhussllshGlhGlssotsssoluuuYlAFhuALhlWGWhEluFLsGhlTGPppssCPssspGhcRFhpAhtTlhaHElsLlssslslhhlohGusNphGlWTFhlLahhRlSAKLNLFLGV.plNsEFLPstLtaLtSaF+ppshshlFPlSVoshTsssshhhppAhss.ssstptlGasLLusLsALAlLEHWFhVLPLPstpLWpWhLPutpssspsst	........M.shhlssLhAlhlWWFSTGhlLhLsph.sc+.....sathohlhusslhshulhGlssoupssossuAYhAFssulhlWGWhEhuFLsGhlTGP+ppsCPssspuhpR.FhtAltThl.aHElullsssshlhhlohs..usNplGhWTFhlLahhRhSAKLNLFLGV.slNs-aLPppLtaLpSYFp+cshNhlFPlSVTlsThssshhhppAhss.ssshptlGhsLLusLhALAlLEHWFhlLPLPsttLWpWsl.sptt.....s.......	0	8	20	23
+12126	PF12292	DUF3624		Protein of unknown function (DUF3624)	Assefa S, Gavin OL	lg7	PFAM-B_3603 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved GRC sequence motif.	21.30	21.30	36.80	36.80	20.60	19.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.66	0.72	-3.58	18	129	2009-08-19 10:46:14	2009-08-19 11:46:14	3	1	129	0	25	82	4	77.20	60	92.95	CHANGED	MuCpsC.....ppshFppKIGRCpRCMhQ..LTlLSlluWslWaahatDsPpslpSIALLhhshAFoGLLhLHL....llhsaRphps	..MACs-C.....ppchFWpKIGRCpRCMDQ..LTVLSVlsWIlWaauF+-cPtSIESIuLIhAGFAFNGLLFLHLWh+aVILPWR+Rp.G.............	0	2	7	16
+12127	PF12293	DUF3625		Protein of unknown function (DUF3625)	Assefa S, Gavin OL	lg7	PFAM-B_3621 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 360 amino acids in length.	18.30	18.30	18.50	18.70	18.20	17.90	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.41	0.70	-5.25	15	185	2009-08-19 10:51:41	2009-08-19 11:51:41	3	4	145	0	18	138	16	235.40	47	72.93	CHANGED	PLoP-Q.IcpLRphh--sp+Atutssss...ssPRlSSlsVNLSPGAo.PllRsusspsoolsFoDuTGuPWsluAssl............suss....ssFslpahtsSsllslQAtp.YssGNloVhLcGLssPVllsLpoGc......sptVDhRlDLRlPtRGPsAps.h..shspspluhhsssLpuFLDGlPPcc..A+RLKssGs...-spsWths-cLYlRTphs.lpstFcpohSSsDGT+lY+LPhT.PhVshShpGpsssLpI-h	.....................Lss-p.I+pLRplhs-s-+Ahsushso...ssPRlo.SloVNLSPG.A.SlPllRsuhs.lSsloFsD.sGuPWP.ussPh.............................susP....phFsl..Q.a........s.....sNhlslpsh+sausGNloVaL+GLusPVlLslsSG-sss............s.opphDuRLDLRlPppGPsuss..s...uhs...............ss........+.......luLaDssLQuFLDG..lPPc-..s+RLKhoGss..sDTplWQp.GD....-....LhVRoRsh.LpspF-pTloSA....DGTHla+LPsT..PlLoFS.l..sGpslplpsE.h.....................	1	8	11	14
+12128	PF12294	DUF3626		Protein of unknown function (DUF3626)	Assefa S, Gavin OL	lg7	PFAM-B_3627 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 294 and 374 amino acids in length.	20.10	20.10	20.60	20.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.89	0.70	-5.38	7	296	2009-08-19 10:53:28	2009-08-19 11:53:28	3	4	251	0	60	210	3	194.40	35	57.46	CHANGED	RlALHFHPDRlDs+GhoVsEGLLc-GlY+sQFETplSNGplSs..GGsRDaWEppLFGsuYp....shcpRPKYGAL-LhhhPsGPAPRFGSCYhlh+spVhuRsTFoahDSa..psP+-KGTlppFDslLAALLsEoFpRpaA...........LGppslpPspllc+LsppLppsh.sth-tssutNLDHYIEAQIHGslSLscDlthLVADPSF+GTsIGc.LpplCc+YtIsLpWHsGhpLsVpcVPsDFRGsuMPsLApRI.....AhstslDAhhIGtAAtcLp+pPppWS-RGshtcshp-LKhLWHVLV+a	.......................................................................................................................................................sspRPhYuALshh..t.sGsA..s..taGpsaF.LsspV......pspsTao.hDoa......p.sh-puphpp..F.h.........h.p.hA............spss.hhs......hphh....ppLht.....hpt.hh.......h.hs.p....ss.t..spYIEApIHG-lsLhcDlctl...l.-sSa.pto.....plht.........................................................................................................................h............................	1	20	37	49
+12129	PF12295	Symplekin_C		Symplekin tight junction protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3634 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a single completely conserved residue P that may be functionally important. Symplekn has been localized, by light and electron microscopy, to the plaque associated with the cytoplasmic face of the tight junction-containing zone (zonula occludens) of polar epithelial cells and of Sertoli cells of testis. However, both the mRNA and the protein can also be detected in a wide range of cell types that do not form tight junctions. Careful analyses have revealed that the protein occurs in all these diverse cells in the nucleoplasm, and only in those cells forming tight junctions is it recruited, partly but specifically, to the plaque structure of the zonula occludens. 	25.00	25.00	36.20	31.70	24.40	21.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-11.17	0.71	-4.37	34	216	2009-08-19 10:55:50	2009-08-19 11:55:50	3	7	161	0	151	211	2	171.50	39	15.68	CHANGED	Dlchll.PllstLcKc-l.hpllPcllph.......s.phhppsls+lLp..............stspts.slossElLlhlHsl........sshKpl.lcAhshCFspps........h..asp-llutsLspls-p.....ssl..PhLahRTllQshptaPsLpsFlh.plLs+Ll.pKplWcp.splWcGFl+CspphtP.....pSatlllpLPstplpphlpch.	.......................................................Dl+hLIPllsuLpKcEl.lthLP+llpL.......s..hlcpshsRlLt........................tsspshssLsPsElLlA.lHsI.....-stc..ssh..........Kpl...lcAsshCFsp+s..........laTp-VLusshpQLh-p..........sPLPhLhMRTVIQuls.....haP.pLssFVh.slLsRLl.hKQ.............lW+....splWcGFl+CspphpP.......pSatl.lL.Q.LPstQLttshpp............................................	0	65	92	126
+12130	PF12296	HsbA		Hydrophobic surface binding protein A	Assefa S, Gavin OL	lg7	PFAM-B_3635 (release 23.0)	Family	This protein is found in eukaryotes. Proteins in this family are typically between 171 to 275 amino acids in length. Although the HsbA amino acid sequence suggests that HsbA may be hydrophilic, HsbA adsorbed to hydrophobic PBSA (Polybutylene succinate-co-adipate) surfaces in the presence of NaCl or CaCl2. When HsbA was adsorbed on the hydrophobic PBSA surfaces, it promoted PBSA degradation via the CutL1 polyesterase. CutL1 interacts directly with HsbA attached to the hydrophobic QCM electrode surface. These results suggest that when HsbA is adsorbed onto the PBSA surface, it recruits CutL1, and that when CutL1 is accumulated on the PBSA surface, it stimulates PBSA degradation.	22.40	22.40	22.40	23.40	22.20	22.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.36	0.71	-4.27	71	311	2009-08-19 10:58:29	2009-08-19 11:58:29	3	9	66	1	199	305	0	119.30	19	53.41	CHANGED	+cssslhsslss.IssplsslssslpsYs.....GG.......shslhsstsslhsslppuhpssps.s..ssloss-uhslhsslt...sLpspltsslssllsKKsthss.......uGhushlhssLpp.pssssshusslpsK	...............................thsshhpslss.lssplp..plssslp.sas.....Gu........sh.tlhssssslhsslppu.hpslps..s...ssL.ost-uhslhss.lp...sLp.splpsslssllsKKs.hsp.......sGhsshlhtsLpp.psssppLuptl.tK...............................	0	28	86	153
+12131	PF12297	EVC2_like		Ellis van Creveld protein 2 like protein	Assefa S, Gavin OL	lg7	PFAM-B_3668 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.	25.00	25.00	50.80	30.80	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.23	0.70	-5.84	5	63	2009-08-19 11:04:06	2009-08-19 12:04:06	3	2	35	0	29	54	0	376.80	49	36.14	CHANGED	GEpauVSYTApL-u+cltsGES...LcLPApLTFpSuSQNcTs...QL..........ossFTITlEEpspVhPNHGlHAAGFllAFLVSLVLTsAuhFlLsRTpsLpsshLoRsRpp+cE....SKLEsusFoSu-sluEDluhNDQllDILThEEPGsMLQALE-LEIATLsRADADLEAsRhQIsKDlIAlLLKNLlSuGHLSPQlE+RMuulFKKQFLsLEsElQEEY-RKMlALTAECsLEoRKKMEuQ+QREpsApEEAEELlK+ssE+sAlECSsLL-pLHuLEQE+Lp+pLtLcQEE-FAKA+RQLAVaQRsELHsIFaTQIcsAspKGEL+.EsAKpLlc-YSKsQ-slEELMDFhQAoKRYHLu+RFAaREYLV+sLQupEo+lpuLLNTAATQLssLIpKhERAGaLcE-Qh-MLLERAQsElhSlKQKLDcDLK	..........G-tasVsYsApLputclh.sG.Es...LpLPApLTFpSsSpNco.......pL..........pAhholsspEphpVhPsHGlHuAGFhlAFllSlVLThsshF.hhs+hpslptshls..cpp...h.p.-........sKL..E....FsSu-uVsED..luhsDQhlDILo.E-PGsMlQALE-LE.....lATLsRAD.....ucLEAsRhQIsKD..lIulLLK.sLsSs.GHLSsQsE++huulFKKQFLhhEsElQ.EEY-RKMlALTAECsLEoRKK.hEsQaQREhsAhEEAEELhK+.suEcsAhECs.sLLcpLHtLEQ-cLp+pLhlppEEshAKApRQLAla........pRsELHpIFasQlcsAlhpGEL+.EsAKhLlpcYuchQ..-slEELMDFhQAsKRYHLu+RFuaREYLVpslQS.-o+lpuLLSoAusQLspLIpKpERAGaLcE-Qh-hLLERAQsElhSlKQKLDpDLK...................	0	7	7	12
+12132	PF12298	Bot1p		Eukaryotic mitochondrial regulator protein 	Assefa S, Gavin OL	lg7	PFAM-B_3672 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 381 amino acids in length. Bot1p localizes to the mitochondria in live cells and cofractionates with purified mitochondrial ribosomes. Bot1p has a novel function in the control of cell respiration by acting on the mitochondrial protein synthesis machinery. Observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms.	21.90	21.90	22.10	22.00	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.94	0.71	-4.32	23	175	2012-10-04 14:01:12	2009-08-19 13:06:09	3	4	149	0	139	193	1	150.20	25	45.85	CHANGED	slpPFP.NPphhoshllSE-L+pcIaccltppuh..SlppVSpcaGlcl.RV-AlV+LhclE+cW.......pschps.hpsaucslhcMhPh..........htsptthtcE.................sls-lPV.ptshsphFhsluEScsFs.lDAA+lhph..tPAs-php+hpshstctpstpp..tpp.pp...hchlhsptpcuE	...............t..pPFP.Ns.hhop.lLS-ph+ppIacplh........ppsh.............olctlStcaslchpRVtAll+LhplEcpa............tpptp.hhhshscshhpMhPh...........tst..h.tE................................................sls-l.s.ph.....s..phFhslsESc.Fs..DAu+hht....ss..t....p.ht.....t..tt.......................p.................................................................................................	0	51	86	122
+12133	PF12299	DUF3627		Protein of unknown function (DUF3627)	Assefa S, Gavin OL	lg7	PFAM-B_3687 (release 23.0)	Family	This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF02498.	20.90	20.90	20.90	22.00	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.74	0.72	-3.94	56	290	2009-08-19 12:19:57	2009-08-19 13:19:57	3	9	69	0	2	291	1	90.20	23	28.40	CHANGED	hhp+h.ph.spcslthPsssppp.pLslhpp......s.spathlpuQcpplcpphp+hp......shsllh-.shcPNshsshNplp-pl....ppc..phchp+p	.................h..p+hs.h.sp-tlhhPs-spppppLslhpp..............tsspashl+sQcpthcpphc+hp......stcllhc.shpPNshshhNplK-pL....tpc..phphpt.................	0	0	0	1
+12134	PF12300	DUF3628		Protein of unknown function (DUF3628)	Assefa S, Gavin OL	lg7	PFAM-B_3692 (release 23.0)	Family	This domain family is found in bacteria, and is typically between 153 and 183 amino acids in length. The family is found in association with Pfam:PF00270, Pfam:PF00271.	25.00	25.00	110.40	109.60	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.37	0.71	-4.24	3	35	2009-08-19 12:23:46	2009-08-19 13:23:46	3	1	34	0	8	33	1	174.10	59	30.83	CHANGED	EQKIPVEPVTsELLTPLPRPER.AsstGEEu-DssGDSVGsIFREAREsRAA-EtRRGGGRSGPG..uRSGust.G+GsRDG.cGG-GRsRsP.RKPRlEGEpDuAAsuAsTPVsuAuAscsP........ulsAA-GE+sPRKRRRRR+GRPVEGAEuV.sus..sssAuPhpPsQVVAKPVRsAAKoGupPSLL	.EQKIPVEPVTuELLTPLPRssR.ssstGEEA---.sGDSVGsIFREAREQRAA-EpRRGGGRSGPG...uRSGu...GtGRR-....G..sGu-G+sRs..RKPR.VEG....Et..s.uAAsustsPVsuAuAs.psP.........usssA-GERsPRKRRRRRpGRPVE..GAEsu.Aus..sssAuPhpPsQVVApPVRsAAKsuupPSLL...........................	0	1	4	6
+12135	PF12301	CD99L2		CD99 antigen like protein 2	Assefa S, Gavin OL	lg7	PFAM-B_3714 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 165 and 237 amino acids in length. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum.	23.50	23.50	23.70	23.70	21.90	23.40	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.23	0.71	-4.57	13	175	2009-09-13 06:10:09	2009-08-19 13:25:43	3	7	56	0	65	166	0	141.50	29	62.51	CHANGED	FDLuDAh......................................ccssssss..........pcPssPKKPusG...............t-FDLtDAlssssshs.t.+sss+spspst............uGuhSDsDLtDssspsshpsDtstsGuus................................sscsstpppstsGhIAGIVuAVusAllGAlSSaluYQKKKLCF........ppu.st.........+ssssEP	...................................................................................................................sppst........................ps.hssp.tPsss................ssFD..Lt.DAlssps.s..............t.s...........................sp.p.................suGsauDpDLtDhhtssth+scts..tussst...t..............................ppss..sttsstsGhIuGls.uAlshAllGAlSSYluYQpKK.hCF..........tt..............................................	0	5	10	25
+12136	PF12302	DUF3629		Protein of unknown function (DUF3629)	Assefa S, Gavin OL	lg7	PFAM-B_3723 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 292 amino acids in length.	25.00	25.00	28.20	25.20	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.73	0.70	-5.00	3	44	2009-08-19 12:28:29	2009-08-19 13:28:29	3	3	6	0	2	44	0	239.70	74	86.97	CHANGED	NSWKNSGFElRSGVAuACRLPKCPTLQRIPTN+DVNcK.EKPYSTFKIDHD..RIQ-MWQRSRIGAKEQNSLRGYQPANSDVNTDS+EVISALDKVRRIEERRKIQNKMRALMEEQHM+DERIQEEpDRVIRKEVLVERDPARKQTspEYSPVRNREKCKPsoWVSATVLAATGKMQQHRYMQTPP.KhNPIKVEAEVQpPSKSVP-NPAoGTTSGQPNQT+T..DMoSRAKWAKSlLELHKTRAKEMDDILSLsGYSN	..........................NSW+pStFt.RsGlAusscLPpCPTLQRIPTNcDVNcK.-pPYSTFKIDHD..RlQpMWQ+SRIGAKEQNSLRGYQPANSDVNTDScEVISALDKVRRIEERRKIQNKMRALMEEQHM+DERIQEEpDRVIRKEVLVERDPARKQTspEYSPVRNREpCKPsoWVSATVLAATGKMQQHRYMQTPP.KhNPIKVEstsQpPspSs.tpsAssTTSGQPNpTpt..sMspRscWsKuhLELHKpRAccMDclhSLtGYSN...........................	0	1	1	1
+12138	PF12304	BCLP		Beta-casein like protein	Assefa S, Gavin OL	lg7	PFAM-B_3744 (release 23.0)	Family	This protein is found in eukaryotes. Proteins in this family are typically between 216 to 240 amino acids in length. This protein has two conserved sequence motifs: VLR and TRIY. BCLP is associated with cell morphology and a regulation of growth pattern of tumor. It is found in adenocarcinomas of uterine cervical tissues.	21.00	21.00	21.10	32.60	20.60	20.90	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.26	0.71	-4.87	9	123	2009-08-19 12:34:45	2009-08-19 13:34:45	3	2	38	0	53	105	1	160.80	47	83.93	CHANGED	MKhGLsLllVGHVNFlLGAlVHGsVLRHlus.ppulshpYsluNlluVsSGlLuIhsGIsAIlhSRNLtphsLpWsLLVlSllsuLLSsACslGLllulshTluspG+sLlusCs..hsss....cphslus-CPFDPTRIYuToLsLWsPslLhSssEushSsRChhlshplhtLtPCtccthptphppts-	.............M+sGLsLlllGHVsFlhuAllHGoVLRaVusspsAls.pYsssNllSVsSullslssGlsAllhSR.L.....p..L+WslhshulhssLLShsCulGLLhululThAstG+tLlusCp..h.ss......c.hshss-CPFDPTRIYsosLsLWh.ullhsssEsshushCs.hshpLhtltPhhtct.pt.h.....p........	0	2	7	22
+12139	PF12305	DUF3630		Protein of unknown function (DUF3630)	Assefa S, Gavin OL	lg7	PFAM-B_3766 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue D that may be functionally important.	25.00	25.00	27.60	26.90	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.18	0.72	-4.10	23	171	2009-08-19 12:35:54	2009-08-19 13:35:54	3	1	171	0	37	112	8	94.20	45	93.84	CHANGED	hplsphphscssL.Lshsu.lDF-sFtthAEsLlttLsspVlE+QWuADRHpWLL-FEGspLhLpaEaYu-hsWLsstpts-.hEVLsaLAsLhpp	....................................FuLs-YhsscG+Lllpsps.FDF-sFsphAppLlslLuApVlEKQhDADlHoWLlDFEGspLhL+....uEHYSpulWLEsLsss.p.ucEpLsalApLhp.............................	0	7	13	26
+12140	PF12306	PixA		Inclusion body protein	Assefa S, Gavin OL	lg7	PFAM-B_3786 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 191 amino acids in length. PixA is thought to be specifically produced in Xenorhabdus nematophila. It is an inclusion body protein.	20.80	20.80	22.30	21.60	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.19	0.71	-4.41	33	128	2009-08-19 12:40:52	2009-08-19 13:40:52	3	2	61	0	31	100	3	167.10	25	93.80	CHANGED	hsphIDlllslDs-p....Ihp.......thsphSpsssp..PTsI.s..ppt.......lYhlsspsphh............supusucLplpsplGDslRWRsoSlot.ss-hslllYchhthss.......hhs......hpsshhphsssspP..sPss......sshsspppshp.haapusltspGp.tsathsFulasp.....pppLhGYapWDPhIslt	.....................phlDlllslDs-t.Ihp.........ph.sssSpsPst...PTsl.s.....pct..........lYhlssss.hs..................supusucLplpAslGDhlpapsTSlst.su-pusllY..phhttsu.......h.s......hsssh.phssu.spP..sPss.....ppshsstppshp.hhapupVtp...sGp...tsathsFulash..................ppsLhGYahWDshIpl.................................	0	4	9	16
+12141	PF12307	DUF3631		Protein of unknown function (DUF3631)	Assefa S, Gavin OL	lg7	PFAM-B_3787 (release 23.0)	Family	This protein is found in bacteria. Proteins in this family are typically between 180 to 701 amino acids in length.	20.80	20.80	20.80	20.80	20.50	20.70	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.46	0.71	-4.38	22	155	2009-08-19 12:47:29	2009-08-19 13:47:29	3	10	132	0	41	145	32	176.80	39	38.04	CHANGED	+MRRRsssEpVtsaRhRpststhpsL+p+LspWhpsphsplcs.Ac.........PshP......t.lpDRAADsWEPLlAVADhAGGsWPp+ARtAulslss.ptspstt....sShsscLLtDlR.ssFtt.tst...ptlsos-LLstLpt.pEuPWus.hs.spsLssppLuphLpc.Y......sI.....cSpslRh..susp.sKGYp+...ssFtDAWsRY	.............................+MRRRtssEpV.csaR.RhstsphctL+-+LAsWssshtstlpp.uh...............PsMPtsVpDRsADsWEPLlAVADsA.GGcWPcpARsAshphss...u.scstp.....sSlGlpLLpDIR.clF.....sst.........-ph.Tu-lLstLpp.-EuPWus.hp..GcsLssRtLuphLtc.Y......uI.....psp.h+...uups.hKGYpp.........spFtDAWsRY.............................................................................	0	13	30	35
+12142	PF12308	Noelin-1		Neurogenesis glycoprotein	Assefa S, Gavin OL	lg7	PFAM-B_3817 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF02191. There are two conserved sequence motifs: SAQ and VQN. Noelin-1 is a glycoprotein which is secreted mainly by postmitotic neurogenic tissues in the developing central and peripheral nervous systems, first appearing after neural tube closure. It is likely that it forms large multimeric complexes.It has a divergent function in neurogenesis. In animal caps neuralized by expression of noggin, co-expression of Noelin-1 causes expression of neuronal differentiation markers several stages before neurogenesis normally occurs in this tissue. Finally, only secreted forms of the protein can activate sensory marker expression, while all forms of the protein can induce early neurogenesis.	25.00	25.00	49.30	49.00	23.20	21.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.33	0.72	-4.21	8	216	2009-08-19 12:51:08	2009-08-19 13:51:08	3	4	46	0	85	186	0	96.70	65	23.41	CHANGED	asuPEEGWQVYSSAQDsDGRClCTVVAPsQshCSRDsRSRQLRQLhEKVQNlSQShEVLDLRTtRDLQYVRshEslhKsL-sKL+ssp-s.+sLsAKuaQE	...........hsPEEuWQVYSSAQDs-GRCICTVVAPpQshCSRDARo+QLRQLLE.K.VQNMSQSIEVL-hRTQRDLQYVc+MEsQMKGL-uKF+QlE-s++phhu+pFp.....................	0	5	16	38
+12143	PF12309	KBP_C		KIF-1 binding protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3821 (release 23.0)	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 365 and 621 amino acids in length. There is a conserved LLP sequence motif. KBP is a binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a type of kinesin interacting protein.	20.10	20.10	20.30	20.50	19.90	20.00	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.16	0.70	-5.49	21	192	2009-09-12 21:52:06	2009-08-19 13:56:09	3	6	137	0	122	185	3	298.00	31	58.76	CHANGED	.h-WAlNAATLSpaYhuptpatpARHpLuAAshlh........sp..p.........t...stptct-pp..............-shcpphAclApsWsKYsLplLpsup.p.....hhc-s.sc.t.php.phpthp........h.....tp...................c..................h.tl........c.ltuhEsplssphshsF--A+tlFhhuppalscAK-aaph-GasT-HlcIlQDhupLa+tLAFFE.psh-.................ppsKMHKRRschLEslhs-LNspaYhtlsRplhaElucsat-Mh-l...................+lt.tc....stptsss+slpK.lNplsppulcaappFl-oh+..............pss.tchPcp..l-pD.h+PhhhA+F+lARLatKllos-spppl-slssSLphYchhscaspppsp...stt.h.psElpls+EMlpLLPhKlpclp	................................................................................................................................-auhNshpLupaahs......pa..put..ppLsuuphlh.....................................................................................t................p.hppt.uplshsah+atl.hhptsp.h........................htp.p.t...p.t.t.......thtt.......................................................................................................................h..h................lts.hcp.pl.sh.hhshsFc-ARplFhhupcalp......cAKcaapl..........-uasT-HlcllQDhStLa+hLAFFE.psh-.................+psKMHKRRlshLEs...lh.s.pLN....s.paYh....h....l.....sRp.l.aElucsah-hh-l...............................+lthhp....p......ppsssch...lpK....lNplsppulcaaphFlcohp.....................................psp..t.h.tp...htp-.hcshhhAhFplu+lh.Kl.hss.sstpplcpltpulphYphh.t....hht.................h......hth..ph..h...p..............................................................................	0	47	57	98
+12144	PF12310	Elf-1_N		Transcription factor protein N terminal	Assefa S, Gavin OL	lg7	PFAM-B_3835 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00178. There is a conserved PAVIVE sequence motif. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins. These include IL-2, GM-CSF, IL-5, IL-2 receptor alpha chain, and CD4 in T cells, IgH, blk, and lyn in B cells, TdT in T and B cells, IL-3 in megakaryocytes, and SCL and Fc-epsilon-RI alpha chain in mast cells.	22.90	22.90	23.90	22.90	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.56	0.72	-4.11	11	183	2009-08-19 12:57:33	2009-08-19 13:57:33	3	4	40	0	81	167	0	91.20	44	17.08	CHANGED	MusslQss-LlFEFAS......ssh.-ctpQhs-sssaPAVIVEpVPpAcLhphYuG..Lsh--p.shhhpDss...tEcpl.....-slhLo.......spsp.ssscpT.cTlpAAEALLsM-SP	.................shslp..st.lhEhsS................ssh.-p.pp.t....csu.aPAVIVE.VPsuc...l...p.Yuu.....Lshs-t.s.hhp-ss....tEp.pl.p...ssh.s.lp.................spsps......ssscsTscTIEAAEALLpM-SP......................................	0	5	12	36
+12145	PF12311	DUF3632		Protein of unknown function (DUF3632)	Assefa S, Gavin OL	lg7	PFAM-B_3839 (release 23.0)	Family	This domain family is found in eukaryotes, and is approximately 170 amino acids in length. There is a conserved ALE sequence motif.	20.70	20.70	22.50	22.40	20.20	20.40	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.35	0.71	-4.48	45	228	2009-08-19 12:58:27	2009-08-19 13:58:27	3	6	62	0	179	234	0	178.10	17	56.69	CHANGED	WphlhphApphshsp.t.........Q-+LVplltplpphssh......................t.hhspptplWp..-LPhhu.......php-tWs................ssssspptpcalNhsuFhA+Lsupshssh.............shaulhsl+suLE..................c.sss.phpstls...sAuhWlhhuGpplhphstth.t.t..tt.st...............hpup...sshshcRWphWccRh	............................................................................................a..hhphupths.pp...........pscLlphlhtlpphssh................................................hh.pttplWp......-.LP.hhs.......thp-h.at...............................................tttsstptppahNhsuFhA+Lhstshhsh..............shhulhhh+puLE................................................................p..ss..th..sshl.sAstWlh..hu..uptlhp.s...tt.t...t.......t........................ts....tsh...s.pRW.hWppph..............................................	0	22	73	140
+12146	PF12312	NeA_P2	NeA_polyprotein;	Nepovirus subgroup A polyprotein 	Assefa S, Gavin OL	lg7	PFAM-B_3843 (release 23.0)	Family	This family of proteins is found in viruses. Proteins in this family are typically between 259 and 1110 amino acids in length. The family is found in association with Pfam:PF03688, Pfam:PF03689, Pfam:PF03391. This family is one of the polyproteins expressed by Nepoviruses in subgroup A.	25.00	25.00	159.40	25.30	19.80	19.40	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.88	0.70	-5.15	4	141	2009-08-19 13:02:51	2009-08-19 14:02:51	3	6	6	0	0	143	0	229.50	76	29.65	CHANGED	MsKFYaSsRRLssashups.+..GohEQWLtshE.DsuFRtpVKpcV.hsRth.ss.RhFpa.lGhGPl-sPthhsWtallpG.....s..........PTpPVKAcEVVssPQPK.VVIPSPPPsPp.PYFRsVGAFAPTRSGFIRATVERLoREREESRAAALFAELPLEYPQGAPL+Lolu.KFAMl+...HTTWR+WYDTSDERlhcsHPGGPsL...PPPP.IQpPPSFpERlpphCphpsCuRAFALETSLGLNhAWVshVsIPSISlCC	.........................MsKFYaSsRRLAsas.ups.HLGGSVEQWLAAIpTDPSFRQTVKEDVQtNRpcPsAIRMFSWKlGaGPIDNPppCsWHFVLTGE..RPsQ...........PocPVKAcEVVVsPQ.........sK.KVVIPSPPPsPs.PYFRsVGAFAPTRSGFIRATVERLTREREESRAAALFAELPLEYPQGAPLKLSLAMKFAMLK...HTTWRKWYDTSDERLhcAHPGGPCL...PPPPPIQpP.PSFpERVREhCRhKSCARAFALETSLGLN+AWVGlVDIPSTSVCC..	0	0	0	0
+12147	PF12313	NPR1_like_C		NPR1/NIM1 like defence protein C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3871 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with Pfam:PF00023, Pfam:PF00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.	25.00	25.00	33.80	33.20	19.80	19.20	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.27	0.70	-4.90	21	173	2009-08-19 13:19:32	2009-08-19 14:19:32	3	15	50	0	40	169	0	153.10	51	34.03	CHANGED	+RLTRstDYpspTEpGp-osKsRLCI-ILEp-..hR.....sPhsu.-sSso..shhuD.DL+M+LLYLENRVAhARLLFPtEA+lAM-IAps-uTuEFssh.s...spsosuphppVDLNETPhh.pc+hhsRhcALoKT............VEhG+RaFP+CS-VLDKhh....pDDLs...DlhaL-+sTsEEpp.KRhRahELp-sVpKAFoKDKt.Ehs+SuhSSSSSSo	..............+RLTRstDYpspoEpGpcusKDRlCI-lLEpE..h+.....p...h..p.s..s..hhs-.phphcLL.LENRVuhA+lhFPhEAchsMpIAphcsT.EFsh...s....t..sttphppsDLN.sPhh.....pcchhsRhpAL.KT............VEhG+RaFPpCStVLs+hh....t-...D.s...phh.htpsTs-cp..K+.RahELp-...l.+AFscDpt.p.sh....tss..........	0	5	24	32
+12148	PF12314	IMCp		Inner membrane complex protein	Assefa S, Gavin OL	lg7	PFAM-B_3921 (release 23.0)	Family	This domain is found in bacteria and eukaryotes. This domain is about 120 amino acids in length. This family is the inner membrane complex of parasitic organisms. This is a cytoskeletal structure associated with the pellicle of these parasites.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.72	0.72	-3.84	22	202	2009-08-19 13:20:31	2009-08-19 14:20:31	3	6	25	0	158	206	7	80.50	33	25.71	CHANGED	sK.hhpE+lcpVsKhlhc..EKlVEVPcl+aV-KIVEVPph.hhpK..hVPKh.lpEpll.hP+...h.pc.h.....+hV-lspl+-ls+ac-hEtsEElhchl	.............hhpEplhc..V..PK.hhp..EKlVE........VPp.lch....V-KlVE..VPphhhhpK.h.......VP+s.lp....Eplh.hs+...h........h...........................................	0	62	92	140
+12149	PF12315	DUF3633		Protein of unknown function (DUF3633)	Assefa S, Gavin OL	lg7	PFAM-B_3949 (release 23.0)	Family	This domain family is found in bacteria and eukaryotes, and is approximately 210 amino acids in length. The family is found in association with Pfam:PF00412.	20.30	20.30	20.70	21.80	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.48	0.70	-5.02	17	151	2012-10-03 04:41:15	2009-08-19 14:21:26	3	12	38	0	112	165	9	180.60	46	40.97	CHANGED	uLsMKl-QplPhLLVERpALNcAh-uEKpGpa+h...sETRGLCLSEEQhlsol......ccs+hG.sppll.shhTEPp+LsR+.CE..VTAILlLYGLPRLLTGuILAHEhMHAWLRLpG.apsLss-VEEGICQVluHhWLEuphhsuss...........ttuuussssuusoSKKu.tpSpaEKKLG-FahHQIcoDsSssYGDGFRpu.tAVp..caGL++TLcHI+hTG	.....................................................................shsM+l-Qpl...PhLLVERpALN-AhpsEKpu....h.ah...h................scTRGLCLSE.E.Q.hlpol............+pPphu.st..p...hh.shhops.+l....s.Rc..CE...VTAILlLYGLPRLLTGSILAHEhMHAaL..RL..p.G...at...sLss..cVEEGICQVluahWLE...uclhssss..........................................ssssss.sssssso...++u..thophE++LucFhhcQIcsDsSssYG-GFRsu.pAVt..p.aG..LcpTLcHl+hT............................................	0	34	77	95
+12150	PF12316	Dsh_C		Segment polarity protein dishevelled (Dsh) C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3969 (release 23.0)	Family	This domain family is found in eukaryotes, and is typically between 177 and 207 amino acids in length. The family is found in association with Pfam:PF00778, Pfam:PF02377, Pfam:PF00610, Pfam:PF00595. The segment polarity gene dishevelled (dsh) is required for pattern formation of the embryonic segments. It is involved in the determination of body organisation through the Wingless pathway (analogous to the Wnt-1 pathway).	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.98	0.71	-11.52	0.71	-4.21	8	185	2009-08-19 13:22:41	2009-08-19 14:22:41	3	12	44	6	82	166	0	185.80	54	29.69	CHANGED	NMAsLSLNDpDGSS.GASDQDTLAPLPHPuAAPWPh.h.uFPYQY.PsPHPa.P..PuYp-..uaSYGuGSAGSQHSEGS+SSGSsRStuttp+pt..cp...............uucpsuGSGSES-aoo+uuhtRt.tccuPstptusssScsSh+u...................uhupppopsShusPGlP..YssshLh.hsssssss..........PPGAPP.VR-LASVPPELTASRQSFphAMG	..................NhAsLsLNc.-GSS..GASDQDTLAPLPp.P.uA.uPWPh...h...uFP...........Y.Q.Y.PsPh.Ph.P..Pu.Y...p-..ua..SY..G.uGSAuSQHS.....E....GS+SSG.SsRSsuttp+ptc.ct.................tspppuGS..G.S.ES-hos+uu...p.s.hcpsssp.ptu..sp....u.ts......................................thpp.ttpssh.ssPGhs..Yss.hhhh.sss..s..s...............................PPGuPP..sR-LuuVPPELT..uSRQSFphAMG........................................	0	7	14	35
+12151	PF12317	IFT46_B_C		Intraflagellar transport complex B protein 46 C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3974 (release 23.0)	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 298 and 416 amino acids in length. IFT46 is a flagellar protein of complex B. Like all IFT proteins, it is required for transport of IFT particles into the flagella.	21.10	21.10	31.90	31.90	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.51	0.70	-4.97	13	166	2009-08-19 13:23:45	2009-08-19 14:23:45	3	3	118	0	110	161	7	199.20	49	58.91	CHANGED	GuYcPt-YspLsVos..El+-LFpYIs+YpPpsh-LssKLKPFIPDYIPAlGDlDAFIKVPRPDucP-sLGLpVLDEPsspQScPsVlsLpLRp..........hucptststsshVsslccA-pN..PKtI-sWIsslpElH..+sKPssTVsYo+sMPDIEsLMQEWPt-hE-lLps.ltlPou-lDhDLppYschlCuILDIPVa.....sshI-SLHVLFTLYpEFKsNQHF	...........................tYsPs-YccLsVos..ElKELFpYIs+....YoPQhl-..L-tKL+PFIPDaIPAVGDlDAFlKV.....PRP..............D...........s........c.....s......D......sLGLh.lLDEPu.spQSDP.oVLsL.Lpp.........................ss+pt.s.h.s..p..phhV....+SlE.s..A-..+.s..PKsIDpWIpsIp................-LH..+oK..PssoVpYs+.sMPDI-sLMQ-Ws.cF.....EE.....hLsp...lpL...Ps.u.....clDssLscYlchlCsl..LDI..Plh..............pshIpSLHlLFoLY.EF+sspHF.............	1	50	61	87
+12152	PF12318	FAD-SLDH		Membrane bound FAD containing D-sorbitol dehydrogenase 	Assefa S, Gavin OL	lg7	PFAM-B_3647 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 168 and 189 amino acids in length. There is a conserved ALM sequence motif. This family is a membrane protein (FAD-SLDH) involved in oxidation of D-sorbitol to L-sorbose.	23.00	23.00	23.00	23.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.03	0.71	-4.57	25	189	2009-08-19 14:35:08	2009-08-19 15:35:08	3	3	141	0	74	162	5	156.60	31	88.15	CHANGED	uloRRplL......hsshussushsstshs.t.hsss.sssss.tsFhslSptLTs...+psL-stlupRlasALhppss.........pFssplspLtslls......ssp.htphpsts.s..lpssspsIlsAWYpGsVtcs.......cuplluYcsALMapsspDsLhlPTYCsssPhaWssp.Pstlss	............................hoRRphL..........sshuhs....us..shsss...h...sht..shs..ss.ssssslssFhsLSptLTu......+psLs...tslGpRlhpuLtcsss.........phsspLsp.Ltshls...............th..sss.s...psluhpIlpAWYhGlV..................cstll....sYcpALMapslpDsLll.oYssstPsaWspp.P.t..s..............	0	12	28	55
+12153	PF12319	TryThrA_C		Tryptophan-Threonine-rich plasmodium antigen C terminal	Assefa S, Gavin OL	lg7	PFAM-B_3676 (release 23.0)	Family	This protein is found in eukaryotes. Proteins in this family are typically between 254 to 536 amino acids in length. This family is the C terminal of a surface antigen of malarial Plasmodium species. It is currently being targeted for use as part of a subunit vaccine against Plasmodium falciparum, the main species involved in causing human malaria.	22.10	22.10	22.10	24.00	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-12.44	0.70	-5.15	52	134	2009-08-19 14:41:50	2009-08-19 15:41:50	3	3	9	0	89	162	0	199.00	31	46.96	CHANGED	cWpsWhpcLEp.-WcpFptpl-pcK.pcWlppK-c-WppWlcphcpKWh+Yscphcp.-apsslhcpu.sWs-ppWcpW.lco-s+phhct-accWlppscpplspahhccW.pWKspK...lhpWLhp-WKpcEschWpcacptph.hchhphtc..+cpWhcWpcRlpcEpp-WppWlctK-phhlps.chspWpcWKs-KpthaspWhcsFlpcWlscKpWphWh	......cWppWhppLEp.-WctFptpl-pc+.pcWhcpK-c-asp.Wlpph-sKWhpaspsh-p.Eapsshh+cs......sWs-.p.pWcpW.lpTcuKphhct-accWlpppcstlspahhpcW.pWKspK...hhpWlhs-WKpcEpphWtcapptph.hphhphtc..+ppahpW+pRlp+Etp-WppWlphK-phhlps.chspW.cWKp-KphhaspWhcsFlspWIpcKpWp.Wh................	0	4	9	65
+12154	PF12320	SbcD_C		Type 5 capsule protein repressor C-terminal domain	Assefa S, Gavin OL, Bateman A	lg7	PFAM-B_3790 (release 23.0)	Domain	This domain is found in bacteria and archaea. This domain is about 90 amino acids in length. This domain is found associated with Pfam:PF00149. SbcD works in complex with SbdC (SbcDC) which is a transcription regulator. It down-regulates transcription of arl and mgr to inhibit type 5 capsule protein production. It acts as part of the SOS pathway of bacteria.	24.30	24.30	24.30	24.30	24.10	24.20	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.26	0.72	-3.97	203	1897	2009-09-13 17:34:05	2009-08-19 15:46:33	3	3	1883	8	311	1271	34	98.00	23	25.01	CHANGED	sshp.sltplc........usl...cclhptl..........tt...........t.ttpt...................salclpl..pscphh..schhpc.lcphhssh.....lclphphtp.pptt.......tpptpslpcl.ssp-lFpchhpppptp	............................shpshthlc.......Gsl....splhpph............tp.......................................tpps........................saLclcl...pscphl..hDhh..p+.lcplhssl..........Ltlcp.sptp..ppp..........pppptslp.c.h..ss.-lFpchhtt.t..s.................................	0	103	188	252
+12155	PF12321	DUF3634		Protein of unknown function (DUF3634)	Assefa S, Gavin OL	lg7	PFAM-B_3607 (release 23.0)	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length.	25.00	25.00	40.00	39.90	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.24	0.72	-4.10	19	141	2009-08-19 14:56:50	2009-08-19 15:56:50	3	1	140	0	30	92	5	101.20	51	97.32	CHANGED	hlhhIlluhh.llahLlhss+...slhch+Fc-G+lsppKG+lP.pFp+ss+cIA+pp.h.oGpl+s.+.psss+LchStsVscplpQRIRNlF...Papta..Kstssp..+pu	......MLYVIllAsh.lIFWLlhlDR...PlLhVpFKDG+lspsKGHhPPoF+HNlh-IAp+-PF.oGElKVYppRoG.sKLsFSKpVPKKlQQRIRNVF...PHQGFs+pSsshKKt.t..........	0	5	10	21
+12156	PF12322	T4_baseplate		T4 bacteriophage base plate protein	Assefa S, Gavin OL	lg7	PFAM-B_3861 (release 23.0)	Family	This protein is found in viruses. Proteins in this family are typically between 208 to 249 amino acids in length. This protein has a single completely conserved residue S that may be functionally important. This family includes the two base plate proteins in T4 bacteriophages. These are gp51 and gp26, encoded by late genes.	24.50	24.50	24.50	24.90	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.21	0.71	-5.07	18	130	2009-08-19 15:13:34	2009-08-19 16:13:34	3	2	86	0	0	114	1244	193.00	25	91.02	CHANGED	hchKlssGs+..+a+sFTVpEYpsll......pspt.pc.pphlscll.sph......htclsppppEalFlplastSlGKs.lchphpCspCuc.ptph.lslpptpl......ps.hhpsuslpIph+aPch................cshtchlscCI-plhts.cp.ashcDLs-pEpppll-hlohcshccIhcthps.s.lhhsltlpC..sspppshslpGLtshFc	................................hchcl.sss+.lph+sFTlc-...aptLl........pscp.tphpphlppll.ssh.......hpcLspt-tEhlalplhspSlGcs.lchpapCs...................p...................Csp.ch.h.lsLpph.pl.....t...cs.hh..h.ss.lpIph+aPp.h.t.................................cshtchlsssIcslhss.sp.hs.hc-ls-............p............-....hpclh....chls.pphppIt.c.hhpp..Pplh.hsl.lpC.psGpppshslcGLtphFt.................	0	0	0	0
+12157	PF12323	HTH_OrfB_IS605	HTH_14;	Helix-turn-helix domain	Bateman A, Gavin OL	lg7	Pfam-B_1210 (release 3.0) & Pfam-B_4602 (Release 7.5)	Family	This is the N terminal helix-turn-helix domain of Transposase_2 Pfam:PF01385.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.29	0.72	-4.63	231	3827	2012-10-04 14:01:12	2009-08-25 09:44:16	3	12	1203	0	846	3330	126	44.80	31	12.81	CHANGED	M.........h+...uaKaRlaP.spcQpphlt+phGssRaVYNhsLstppctYc..p.stc	...........M......pua+h+lhP.stpQpphlp+thGssRalaNtsLshppctacttt.............	0	214	582	720
+12158	PF12324	HTH_15		Helix-turn-helix domain of alkylmercury lyase	Bateman A, Gavin OL	lg7	Pfam-B_3505 (release 6.5)	Domain	Alkylmercury lyase (EC:4.99.1.2) cleaves the carbon-mercury bond of organomercurials such as phenylmercuric acetate. This is the N terminal helix-turn-helix domain associated with Pfam:PF03243.	21.30	21.30	21.30	21.90	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.43	0.72	-4.32	6	128	2012-10-04 14:01:12	2009-08-25 11:23:53	3	4	102	13	18	80	9	73.50	39	34.60	CHANGED	ptpplusplspthspGptspuhshLaRPLLp.LApGcPVohEslAstTG...+ss-cVtpVLpptPusEhD-cG+IlG.hG	..............................phus.l.pphspsp.ssuht.LhhP...LL+.LAc.GcPVohpsLAuthG...hPsEcVtpVLpph..s..u..sEYDcpGpIlG.aG...........	0	10	14	17
+12159	PF12325	TMF_TATA_bd		TATA element modulatory factor 1 TATA binding	Wood V, Coggill P	pcc	Pfam-B_97264 (release 23.0)	Family	This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes [1]. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs [2]. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal [3] and plant [4] cells. The Rab6-binding domain appears to be the same region as this C-terminal family [3].	28.70	28.70	28.80	28.90	28.60	28.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.48	0.71	-4.38	78	241	2009-08-27 10:02:35	2009-08-27 11:02:35	3	5	216	0	179	241	2	116.50	33	13.47	CHANGED	hsshhuhsssstussspllE+huuslRpLEuElssh+pElu+LpspRsphppElVcLhcEsEch..+ptspclppLcpplcsLcpRapssLphlGEKoEpVEELcsDlsDLKchY+pQV-phl	................................h......pssthussspllEphpupl+phE.............uElsphpp.ElupLpppRsphppElVc....Lhpps-ch.........cptspclt.pLcpplccLcp.RYpohLphhGEKsEclEEL+tDltDlKphY+pQl-phl..........	0	52	92	144
+12160	PF12326	EOS1		N-glycosylation protein	Wood V, Coggill P	pcc	Pfam-B_29822 (release 23.0)	Family	This family is not required for survival of S.cerevisiae, but its deletion leads to heightened sensitivity to oxidative stress. It appears to be involved in N-glycosylation, and resides in the endoplasmic reticulum.	21.50	21.50	22.70	21.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.14	0.71	-4.56	19	118	2009-08-27 10:17:50	2009-08-27 11:17:50	3	6	105	0	85	125	0	130.70	34	35.05	CHANGED	psRuSEahLsulWClVSuYLoYulLDuLMVRWIlpYSTsAAIlRhhSMSh..lhIThEhhLluuhSsp.tcYhLHsWIlISChLThsYIhQsalTSNLphh.......................................................................................thpppRphDlYpIsVFsVVPVGlASFlTMlGLLRsLh	.......................p....sEhhLs.lWChsohYLoa.hhDsLMsRWllpYos.AsIlRlLohss.......h..h..lThplLhLouhS..s-..chhL.sWIhIussLThhYhh..........................................................................................................................................................................................................................................................................................................h........................................................................................	1	20	45	71
+12161	PF12327	FtsZ_C		FtsZ family, C-terminal domain	Bateman A, Sonnhammer ELL, Griffiths-Jones SR	pcc	Prosite	Domain	This family includes the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ is a GTPase, like tubulin. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea.	21.70	21.70	21.70	21.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.94	0.72	-3.92	26	5666	2012-10-03 12:11:42	2009-08-28 16:26:11	3	7	4977	45	1192	3761	2518	93.00	47	24.25	CHANGED	GhAMMGhGpAsG...-sRAt...cAscsAlssPLL-..lslpGA+GlLVNITGG.DhoLtEs-ssuptIp-tlD.s-AslIaGsslDsphpsplRVoVVATGlc	........................GpAhMGhG.A.sG.......EsRA.h...cAActAIuSPL.LE...ss.lpG.A.c..GV..LlN.I......T........GG..........D..........l.....oL..hEhppAus....h.lp..pt.s.....s........p........s.....A..s.l.....I.aG.s.s.l.D...p...s.h...p....D..c..lRVTVlATGh....................................	2	392	791	1014
+12162	PF12328	Rpp20		Rpp20 subunit of nuclear RNase MRP and P	Wood V, Coggill P	pcc	Pfam-B_33537 (release 23.0)	Family	The nuclear RNase P of Saccharomyces cerevisiae is made up of at least nine protein subunits; Pop1, Pop3, Pop4, Pop5, Pop6, Pop7, Pop8, Rpr2 and Rpp1. Many of these subunits seem to be present also in the RNase MRP, with the exception of Rpr2 (Rpp21) which is unique to RNase P. Human nuclear RNase P and MRP appear to contain at least 10 protein subunits, Rpp14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, Rpp40, hPop1 and hPop5, although there is recent evidence that not all of these subunits are shared between P and MRP. Archaeal RNase P has at least four protein subunits homologous to eukaryotic RNase P/MRP proteins [2]. In the yeast RNase P, Pop6 and Pop7 (the Rpp20 homologue) interact with each other and they are both interaction partners of Pop4 [4]; in the human MRP Rpp25 and Rpp20 interact with each other [2] and Rpp25 binds to Rpp29 (Pop4) [3].	24.60	24.60	24.60	24.60	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.70	0.71	-4.54	44	133	2012-10-03 06:24:24	2009-08-28 16:42:55	3	3	129	1	93	213	7	130.40	29	71.76	CHANGED	phtpslYVsopTPahSulKRlpKhLcptp+..........................pt.........tt..................tt..t...............c.Vhl+uhG+AIpKslslutaF...pcp......shcVclpTuoVpVlD-lh...........................................................................................................s-tc-cpscsRpRhVSsVElp	.........................................p...pslaVsopTPahStlKRlpKhLctst+.....................pt..............................................t...............tppt.Vhl+GhG+.AIpKslslutaF.......pppp......shpVplpTuTVplVD-lh.tt........................................................................................................................................................scscscpspsRhRtlSslclt.........................................................................................................................................................................................	0	19	39	65
+12163	PF12329	TMF_DNA_bd		TATA element modulatory factor 1 DNA binding	Wood V, Coggill P	pcc	manual	Family	This is the middle region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures.[1]. The whole proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein.  TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal [3] and plant [4] cells.	35.00	35.00	35.00	35.20	34.90	34.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.44	0.72	-4.17	51	411	2009-08-28 15:49:32	2009-08-28 16:49:32	3	20	270	\N	165	357	0	74.30	39	10.97	CHANGED	sshpcplpEKDppIspLhcEGppLS+p-hcppspIKKLRtchp-t-..pplsph.p...p+hpch-pclpplcpchcpt-	...................t..htppLttKctplAph.pE...hEKL.cs...cupo.ccLcpcscEsE..+phscLp....pKls-LEcElssLchhLsus-............	0	41	75	128
+12164	PF12330	DUF3635		Domain of unknown function (DUF3635)	Wood V, Coggill P	pcc	Wood V	Family	This family may be a potential Haspin-related leucine-zipper. A leucine zipper was proposed to be present towards the C-terminus of human Haspin, (up-stream of the current family) [1]; however, as this domain would appear to span several helices and be largely within a loop structure [2], the actual zipper might be further downstream, and be this family, which is the very C-terminal part of the Sch. pombe sequence.	21.60	21.60	21.70	21.60	21.00	21.50	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.47	0.72	-3.92	6	219	2009-09-03 10:35:38	2009-09-03 11:35:38	3	7	187	7	156	232	1	85.70	24	13.60	CHANGED	c-LFsGcG.........DYQF-IYRLMRp.hps..sWupFcPhTNlLWLaYLocplLpKhshKohs..sssshRphhcpI...........pch+phhhshcSto.hpCuc.Lh	...........................................hFpG.p.s..............chQa-lYRhM+p.hps.............sWp..papPhTNllWLpYLhcpLlpphp.hpph......pt.........p.............................................................................................................	0	61	91	130
+12165	PF12331	DUF3636		Protein of unknown function (DUF3636) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 160 amino acids in length.	25.00	25.00	75.40	46.00	21.60	17.20	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.78	0.71	-4.63	17	75	2009-09-03 15:34:27	2009-09-03 16:34:27	3	2	70	0	58	70	0	145.80	35	19.84	CHANGED	suTcsLpLLYhhAsuChp................pspslppFW+plpaDFlLhMLssp.QslsDIhLhLslLSTSlhssSFGsl.so.......cpcQhssEN...aIlDRlusLLsEhPpsD.......EGttPaoshclhphRLEslthLTpluFssh.....tptuuhhlApHPoALuRLlRshaDEL	................ssTcsLplLYhhAhuChp.......................spps.ppFW+phphDFlLhMLssp.Q.hsDIhhhLpLLsTShhssShGPl.ss.......cspphsspp.............hIIDRVushLsEhP...........sptshoshclsslRltAhphLsshAhosh..........uuhhlApHs..sAlsRllpslpspl......	0	8	25	44
+12167	PF12333	Ipi1_N		Rix1 complex component involved in 60S ribosome maturation	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 91 and 105 amino acids in length. This family is the N terminal of Ipi1, a component of the Rix1 complex which works in conjunction with Rea1 to mature the 60S ribosome.	21.50	21.50	21.50	22.40	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.26	0.72	-4.05	43	316	2009-09-03 15:39:04	2009-09-03 16:39:04	3	6	274	0	202	292	0	102.20	27	18.54	CHANGED	sssslpsahphllhalpuAMTHls..scIRtsohchLshLlchsspp.....sptsahK..hLpsahslLuhs.....tst.........s.shs....hstst............pstcthsphLpsLtpFL	.......t..ppltsahsllhsalpuAMTHls..tsIppDSlclL-lLLcthPs.................hs.s..thsp........lLps..Flplluap.......tpp..................ht.shs.ttp....................pstphphphL.tLtpFL......................................................................	0	59	101	160
+12168	PF12334	rOmpB		Rickettsia outer membrane protein B 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 220 amino acids in length. The family is found in association with Pfam:PF03797. This family is the middle region of one of the outer membrane proteins of Rickettsia which is involved in adhesion to eukaryotic cells for uptake.	25.00	25.00	115.00	115.00	19.70	18.80	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.40	0.70	-4.97	9	158	2009-09-03 15:40:00	2009-09-03 16:40:00	3	2	90	0	6	136	0	200.30	77	15.45	CHANGED	INFAu.s.ussDTlLNVGcGVNLYATNITTsssNsGSFsFsAGGTNIVSGTVGGQQGNKhNsVpLDNGTTspFLGNAhFNGtTTIcuNSTLQIGGNYTsDalp..SADNTGIVEFVNscsITVTLNKQAssVssLKQITVSGPGNVVINpIGNAuNshGhsTsTIuFpN....ASLGAsLFLPSulPhDs......LTIKSTV...GNGssGs.FNsPhVlVSGlDSsIAsGQl	.IpFus.u.spsDolLsVGcGVNLYAsNITTssANsGSFhFpuGGTsIVSGTVGGQQGNKFNTVsLDNGTTVKFLGNATFNGpTTItANSTLQIGGNYTADFVA..SADGTGIVEFVNTsPITVTLNKQAAPVNsLKQITVSGPGNVVINEIGNAGNsHGAsTDTIAFEN....SSLGAsLFLPSGIPFNDAGNhhPLTIKSTV...GN.cTAsG.FDVPtVIV.GVDSVIADGQV	0	1	1	1
+12169	PF12335	SBF2		Myotubularin protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with Pfam:PF02141, Pfam:PF03456, Pfam:PF03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.	22.30	22.30	22.30	22.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.67	0.70	-5.03	11	260	2009-09-03 15:43:16	2009-09-03 16:43:16	3	40	96	0	156	235	0	186.70	35	14.02	CHANGED	PhGPsls.......slh-cpsssh.NSA...RRLEVlRNCISaIF-NKhhEA+KohPAVLRuLKu+sARlsLscELsh+sQpNRs.lLDHQQFDhVVRhMNsALQDsSuhDEauVAAALLPLoouFCRKLusGVpQFAYTClQDHsVWsN.QFWEssFYp-VQspI+uLYL...........................t.t.sppp.pstsstscstEpoAl-lAA-QhRhWPTlsc-cQpELlppEESTlaSQAIHaANpM	...............................................................hht.....h.sSA...pRLEVlRsCl....shlF-sK.....hh-scKhhPAshRsL+s+sAR.sLspELth.a........lp.p.N.......+A..hLDcQQF-..hllRhMNssLQ-..sos..h-Easl..AAuLL.PLs.osF...hR........K.L....us...G...l...pQ.FAY..o.slQ........-H.slWps.QFWEuhFYs...sVQp.pl+...sLYLp...............................................pp.t......t.........t..t.p...t.t.......sp.tp.os.h-lss...pQ.t.....s..ht.t.ptphhppEEshlhuQAhHaAshM...............................................................	0	45	61	105
+12170	PF12336	SOXp		SOX transcription factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00505. There are two conserved sequence motifs: KKDK and LPG. This family is made up of SOX transcription factors. These are involved in upregulation of nestin, a neural promoter.	22.10	22.10	22.10	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.16	0.72	-3.37	6	314	2009-09-03 15:46:08	2009-09-03 16:46:08	3	3	110	1	118	281	0	77.80	43	26.18	CHANGED	YRPRRKTKTLLKKDKYSLPGsLls..ssusss..sVusG..hDsY.sHMNGah..NGuYShMQ-.QLuhspHsshss..............ppl.HRY	............YRPR..RKTKTLhK.K.D....KY...s...L.P....u..s..lls...................ssu...sh...t..........sVu.....u....................h.s........th..shh.NGa.......suu...t............hhtc..Lu......Qh.u.hsu...........................................................................	2	18	32	68
+12171	PF12337	DUF3637		Protein of unknown function (DUF3637) 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00073, Pfam:PF08935.	25.00	25.00	134.10	133.10	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.32	0.72	-3.99	2	82	2009-09-03 15:48:34	2009-09-03 16:48:34	3	4	13	0	0	84	0	67.00	90	4.17	CHANGED	MACLKhFSLKsKsKsHSYSPRtlELKaN.DFsFKPRPLAsLLRLEPSDoKhRRVECsEVEhDSWYPN	MACLKIFSLK+KsKSHSYSPRtlELKYNSDFAFKPRPLAPLLRLEPSDTKTRRIECAEVEYDSWYPN	0	0	0	0
+12172	PF12338	RbcS		Ribulose-1,5-bisphosphate carboxylase small subunit	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00101. There is a conserved APF sequence motif. There are two completely conserved residues (L and P) that may be functionally important. This family is the small subunit of ribulose-1,5-bisphosphate.	25.00	25.00	28.00	26.30	22.50	20.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-8.37	0.72	-4.19	46	352	2009-09-03 15:49:56	2009-09-03 16:49:56	3	4	116	0	42	353	0	40.00	53	24.28	CHANGED	ASShh.So.AsVAo....RsssAQA.oMVAPFsGLKSsuuFPlTRKsNss	..............uuhh..so.sshss............ssupA..ohVAPFsGLKSoA.uFPVo.RKsss....	0	6	22	34
+12173	PF12339	DNAJ_related		DNA-J related protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 130 amino acids in length. The family is found in association with Pfam:PF00226. There is a conserved YYLD sequence motif. Mostof the sequences in this family are annotated as DNA-J related proteins but there is little publication to back this up.	25.00	25.00	42.80	29.00	24.20	15.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.72	0.71	-4.27	41	208	2009-09-03 15:51:57	2009-09-03 16:51:57	3	2	207	0	51	141	15	125.50	47	61.22	CHANGED	tpsPLlhsllplLpp.pspuhp.apLhppLpppshh..splc.ssptsLF+ppFLLhNALYpLQppLhscp..hLplpshsIpLh..sh..tsssts..h.....t....sDsLRcYYLDWpsa.csspspVccLLssFWpcap	.......................................-NPLlWPIhplL+c.pPpGWKlHsLAscLpchGhh....ssL..D.pPccDLFKRNFLlMNALYQLQ-pLaP-p..WLQVcAMsIhLhshhp......sp.tp..l......-....sDPLR-YYlsWpNY.-ssEu-V+RLLspFWoRYp.............	0	13	25	40
+12174	PF12340	DUF3638		Protein of unknown function (DUF3638)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 230 amino acids in length. There are two conserved sequence motifs: LLE and NMG.	25.00	25.00	25.60	27.30	23.00	21.80	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.41	0.70	-5.37	26	218	2009-09-03 15:54:27	2009-09-03 16:54:27	3	22	110	0	186	233	13	197.50	30	6.43	CHANGED	GHsNWcPh-aP-WLLLEIEusIhIRpsQhpVAtphIsPsuGsNuVLQhNMGpGKoSVIlPMVAusLAssspLlRllVPKsLhpQstQlLpo+LGGLlsRclhHlPFSRcTpsststlpthpplaccshppuGllLs.PEHlLSFKL.GLpplh-u+hs.ApshlchppWhcphuRDllDESD.sLulKhQLIYs.GoQpsVDGpPcRWplsQsLLuLVppashsLppca	..................taps......PcaLlhEh-sslhlRttQh....p....lApp.h.h.s.....s...t..ps..pss.lh.QhpMGpGKooVIhPhluh..h..L......A....ss..p........p...LlpllVscs.Lhpph.hphLpp+l.u.u.l.l.sR.plhplPF..........sRph..p..h.s................p.......t.h..ph....h.t..phhppsh.p...ptG.ll.l.spPE..p...lhSh.....p......Lh.s.....l......p.p.h.....h......p...t..p..........t..............s..........pt........hhp....htp.hh.p.p...sp......D...llDEsD..ht.h+hpLlYs.Gtt.slp.t..s.RW.hhptlhthh...........h....................................	0	70	126	164
+12175	PF12341	DUF3639		Protein of unknown function (DUF3639) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00400. There are two completely conserved residues (E and R) that may be functionally important.	21.60	21.60	21.60	21.60	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.76	0.72	-6.62	0.72	-3.94	35	247	2009-09-03 15:55:19	2009-09-03 16:55:19	3	17	204	0	161	240	3	26.90	40	2.85	CHANGED	GEplpulAsussalsVsTStsalRlFo	....sEplpAlulupu...alAssTSspalRlFo.	0	38	75	125
+12176	PF12342	DUF3640		Protein of unknown function (DUF3640) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 25 and 211 amino acids in length.	25.00	25.00	45.10	44.30	17.50	16.00	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.59	0.72	-6.63	0.72	-4.41	5	29	2009-09-03 15:56:06	2009-09-03 16:56:06	3	4	2	0	0	24	0	25.10	79	5.26	CHANGED	MSLLTNRhCRRVDKDQWGPGstGRTP	MSLLTNRhsRRVDKDQWGPGshG+sP.	0	0	0	0
+12177	PF12343	DEADboxA		Cold shock protein DEAD box A	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 68 and 89 amino acids in length. The family is found in association with Pfam:PF00270, Pfam:PF00271, Pfam:PF03880. This family is the C terminal region of DEAD box A, a protein expressed under conditions of cold shock which is involved in various cellular processes such as transcription, translation and DA recombination.	22.50	22.50	22.90	22.90	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.90	0.72	-3.72	6	500	2009-09-03 15:56:51	2009-09-03 16:56:51	3	4	494	0	21	135	1	63.20	88	10.05	CHANGED	GGERR..GG...GRs.FuGERREG.....GRp..G-RREGuss........uGERR.u...RDGQR..APRRDDuAA.......ssRRRFG.DA	.........GGERR...GG.....GRG.Fu.GERREG........GRNFS.GERREGGRGDGRRFSGERREG....R........APRRDDSTG............RRRFGGDA..	0	1	5	13
+12178	PF12344	UvrB		Ultra-violet resistance protein B	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00271, Pfam:PF02151, Pfam:PF04851. There are two conserved sequence motifs: YAD and RRR. This family is the C terminal region of the UvrB protein which conveys mutational resistance against UV light to various different species.	21.20	21.20	21.30	26.80	20.90	18.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.14	0.72	-4.43	509	4463	2009-09-03 16:03:57	2009-09-03 17:03:57	3	9	4402	11	984	3212	2153	43.90	56	6.48	CHANGED	hYADc.lTcSMpcAI-ETpRRRphQhtYNccHGITPpo.lpKplp-	.......hYAD+..ITsSMpcAI-ETpRRRchQhtYNccHGIsPps.lpKclp-.....	0	335	664	843
+12179	PF12345	DUF3641		Protein of unknown function (DUF3641) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF04055. This family consists of proteins which are commonly annotated as Radical SAM domains but there is little annotation to back this up.	21.50	21.50	21.50	24.70	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.86	0.71	-4.31	83	232	2009-09-03 16:04:57	2009-09-03 17:04:57	3	10	220	0	99	252	228	133.40	46	40.40	CHANGED	LPPsQtpLEt-YKctLtpcaGIpFNpLaTITNhPIuRFtphLpppGpapsYhphLpssaNssslpslMCRsplSVsWpGplY..DCDFNQMLslPs.......pspt.hplp-Lhp.ss...ltsppItsusHCYGCTAGsGSSCGGu	...........LPPsQtsLEt-YKcpLtccaGIpFNpLaTITNhPIuRFtphLt........ppsphpsYhphLtssaNssslpslMCRsplSVsWpGpLY..DCDFNQhLslsh...................supt.hplp-lhpts...htsppItsusHCYGCTAGsGSSCGGu....................	0	36	73	93
+12180	PF12346	HJURP_mid	HJURP_repeat;	Holliday junction recognition protein-associated repeat	Coggill P	pcc	manual	Domain	Vertebral Holliday junction recognition proteins carry an SCM3 domain at their N-terminus as do the eukaryotic fungi, but they also carry this central, conserved region. The function of this family is not known. Further downstream there is also a repeated domain, also of unknown function. Investigation of Scm3 and associated proteins is likely to be directly relevant to understanding the mechanism of HJURP-mediated CENP-A chromatin assembly at human centromeres.	25.00	25.00	68.70	48.10	19.10	19.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.46	0.71	-3.96	4	36	2009-09-04 12:32:37	2009-09-04 13:32:37	3	6	24	0	14	39	0	105.50	61	17.80	CHANGED	MSRLLSTKPSSIISTKTFIMQNWNSR+RHRtKSRM..NKTYC+GuR+SQRSuKEsFlPCSEPVK-TGALRDCKNlLDVus+KTGLKLEKAFLEVNKPQIHKLcPSWKELKVTPSKYSS	.MSRLLSoKPSsIISTKT.FIhQNWsSRRRH+pKsRM..N+TaC+Gu+hSpRSu+-s.ssCSEPsKEsGsLRDCcNlLDVSs+K...TGLKLEKAhLEVNKsQlHKLsPoWKELp....shPpK..s..........	0	1	1	1
+12181	PF12347	HJURP_C	HJURP_repeat;	Holliday junction regulator protein family C-terminal repeat	Coggill P	pcc	manual	Domain	Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, Pfam:PF10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.	21.60	21.60	22.10	22.10	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.97	0.72	-4.39	13	404	2009-09-04 15:55:35	2009-09-04 16:55:35	3	7	88	9	135	350	1	63.80	39	14.80	CHANGED	+phs.s..ppsscP-hph...s+sEc+Y+EIcEEFDphaQpYpLust..PtphshsssssVSshpuus	................G....C-SP.-PD.sp.sl....oPpoE-KY+KIsE-hDhhhpch.p.h..ss........lP.....s.N.......F......sMPVolPVos.suh.s............................	0	16	26	59
+12182	PF12348	CLASP_N		CLASP N terminal	Mistry J, Wood V	jm14	Manual	Family	This region is found at the N terminal of CLIP-associated proteins (CLASPs).\	  CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules [1][2].  In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present.  In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1 [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.32	0.70	-5.00	57	1343	2012-10-11 20:01:02	2009-09-07 16:10:40	3	32	291	1	840	1391	6	203.10	18	24.51	CHANGED	l-pphpphhshFpt.+EoEtNWthRppslhplRpll+Gs.sspsh.sshlssl+..th.puIh+shsSLRTolsssuCpLlp-luhhhtsp.l-sh.s-hlh.sLl+hsussKclsupsAshslssllssss..ss+l.hphlhhAhp-KNspsRthustWLphhlp+hs.............pppthptss.....hh....chhccslt+sLsDAsssVR-shRssaWpa..................hphaPs+Acplh..spL-sps++hlc	.....................................................................................t.tp.Wp.+.p....sl.tl....pt..h...h...............tt...........................tt.hh.ttl+.........shht.p.hp.shp..st...ls....ppuh....thl....s.p.Ls....p...t..........h...tp..........p...hcph....sct....ll..s............sLlphh...s..s.....s..p.c.h...lppsuptslpt.lhp...p.....ss......s...pl.....h.thl.ts..s.h...ps.K..s.stlRpp........sht.aLtt.hlpphs.................................h..t...pph........h...........phlht...tl...t...ptlpDsssplRptAppshht.h..........................hp.h..hs.t...............................................................................................................................	0	270	417	646
+12183	PF12349	Sterol-sensing	SREBP-CAP_SSD;	Sterol-sensing domain of SREBP cleavage-activation	Wood V, Coggill P	pcc	Wood V	Family	Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER [1]. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini [2]. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein [4]. WD40 domains are found towards the C-terminus.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.75	0.71	-4.76	34	952	2012-10-02 18:57:54	2009-09-07 17:54:24	3	33	349	0	545	2789	1133	148.90	25	14.06	CHANGED	hlcS+hsLulsGllhlhholssohGhhuhhG..lshohlshpVhPFLlLulGlDNhFlllpuhppsspshs.....cpRlucuLucsGsSlhloulo-hlsFh.lGshoshPAlpsFslaAulAlhhDFhhQlThFsAlLulDh+Rp.tpschchhsphps	..........................................................h..tS+hhL.uluulhhl.hhS...h...hhu.l..u..l.....h.....s...h.....l....G.......ls..hs.h...............l.h.t.ps.l..P.F.......L...l....L...............s..l......G.......l..-...p...h..h.....l.L....s....p....s.......h......h.....p....s.......s...p.p.tph.........................ppp...l...u......c.ulsp...hGso.lhh.s............sls.....ch..ssh.............h....l...G......s...h..o..s.............l..s.u..l..c.tFs......hh..A.uh....sl.lhs.ah.....l...........h.o...h...F.s.u.l.L.o...l.clchp...ttt..........t...............................................................	0	161	245	407
+12184	PF12350	CTK3_C		CTD kinase subunit gamma CTK3 C-terminus	Wood V, Coggill P	pcc	Pfam-B_12814 (release 23.0)	Domain	The C-terminal domain kinase (CTDK-1), is a three-subunit complex comprised of Ctk1, Ctk2, and Ctk3, that plays a key role in regulation of transcription and translation and in coordinating these two processes. Both Ctk2 and Ctk3 are regulated at the level of protein turnover, and are unstable proteins processed through a ubiquitin-proteasome pathway. Their physical interaction is required to protect both subunits from degradation, and both Ctk2 and Ctk3 are required for Ctk1 CTD kinase activation [1]. The mammalian P-TEFb is mirrored by the combined complexes in yeast of the CTDK1 and the Bur1/2 [2]. It is not clear what independent function this C-terminal domain has.	25.00	25.00	33.20	37.90	18.30	18.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.78	0.72	-3.95	31	130	2009-09-09 12:11:31	2009-09-09 13:11:31	3	4	127	0	99	127	0	67.90	39	23.79	CHANGED	lsKppI.hpRhE-DRERHKR.+EshWslst................psEF.cphWschsshs-sp.psshc-hpEhpphspt	.....sK+QI..pRlEEDRERHKRhREshWslstss...........................................psEa.cphW-cso..shs--D.htsh--ht-hpphh..t..................	0	26	54	84
+12185	PF12351	Fig1		Ca2+ regulator and membrane fusion protein Fig1	Mistry J, Wood V	jm14	Manual	Family	During the mating process of yeast cells, two Ca2+ influx pathways become activated. The resulting elevation of cytosolic free Ca2+ activates downstream signaling factors that promote long term survival of unmated cells.  Fig1 is a regulator of the low affinity Ca2+ influx system (LACS) [1], and is also required for efficient membrane fusion during yeast mating [2].	25.00	25.00	25.10	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.38	0.71	-4.40	32	158	2012-10-03 00:20:40	2009-09-10 11:12:12	3	2	113	0	119	187	0	182.80	33	65.11	CHANGED	hhppssss......sstp.lplRsGYhGlClspss..............ss....hhC.....ptshssLsshlp..................ssss.sLNLltlApsFpspllaPhllhssllLshlsFlllsh...............h..lhPh.st...lpphshsluhls..slhhhlushapHhuss.AusshstshohGh...lpuphGspAhshsW..huFsh.lhl.sslulhhhhhp	..................................................................s....ssh...sssp.lplRlGYhGlClpsss......................ushlC.........spsussLup.lp................................spp-.sLNL..lhlAppF+-tlVFPYLl.hs..ulllsh..ls..hllLshhs...................................h..lpPFssp...VsphsLulhhlu..slhhhl.ushWQHsuus.Ausplspshu.Gs....lp.utsGssAhlhuW...huFsh.lll....lslGLhhhhLp......................	0	22	58	98
+12186	PF12352	V-SNARE_C		Snare region anchored in the vesicle membrane C-terminus	Coggill P	pcc	manual	Domain	Within the SNARE proteins interactions in the C-terminal half of the SNARE helix are critical to the driving of membrane fusion; whereas interactions in the N-terminal half of the SNARE domain are important for promoting priming or docking of the vesicle Pfam:PF05008.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.74	0.72	-3.90	20	1258	2012-10-01 21:14:52	2009-09-11 17:34:43	3	20	319	2	844	1215	13	65.10	23	27.89	CHANGED	-tlh+pss+lcsSpRhhsEs.shGtullpsLppQRpsLpssps+lpssssslstosplLpshpRRh	..........................h.cppp.plpp.op.p...hhs-s.p.hGtsshpsLtpQRppLppspp+....lhssss...plstuppllptlp+R.......................	0	290	470	692
+12187	PF12353	eIF3g		Eukaryotic translation initiation factor 3 subunit G 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 130 amino acids in length. The family is found in association with Pfam:PF00076. This family is subunit G of the eukaryotic translation initiation factor 3. Subunit G is required for eIF3 integrity.	22.00	22.00	22.00	22.00	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.80	0.71	-4.22	47	378	2009-09-14 13:49:11	2009-09-14 14:49:11	3	11	284	0	262	367	3	119.60	34	40.69	CHANGED	sPssplhps.sGsKslhpY+hs--GcKlKlspph+..hhpc.+Vs+slAcRKpWsKFGsspsssP.GPsstTT.luE-lhhphspshcppppccppp.......ttpsssshlpCRlC.p.G-HaTs+CPaKsths	........................................s..phhss.p..GhKslhpY+...hs-.-.G.c.......K.lKl.s.+ph+..h.pc.+ls+tVA...c.R+........s.W..sKFGpsptc.s.s.GPs.ss....TT.tl.uE.-lhhp.........hssshcptpppcppp...........httthspphlpCRlC..p..G-HaTs+CPaK-sh.s........................	0	86	144	213
+12188	PF12354	Internalin_N		Bacterial adhesion/invasion protein N terminal	Gavin OL	lg7	Prosite	Domain	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00560, Pfam:PF08191, Pfam:PF09479. There are two completely conserved residues (I and F) that may be functionally important. Internalin mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin. This family is the N terminal of internalin, the cap domain of the protein. The cap domain is conserved between different internalin types. The cap domain does not interact with E cadherin, therefore its function is presumably structural: capping the hydrophobic core.	24.10	24.10	24.50	24.30	23.70	24.00	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.70	0.72	-4.35	32	845	2009-09-14 13:50:09	2009-09-14 14:50:09	3	116	41	39	12	749	0	55.90	39	10.30	CHANGED	h++p.hl+thlhhhLlhhlsh.hlshs.ssclpA.ssIspPsPINpIFPDssLAcsl+p	...........++pshhK.hLlsh.Llhhhul..WIsh.usGscsQA..to...IspPTPINQIFsDsALA-slKs..	0	12	12	12
+12189	PF12355	Dscam_C		Down syndrome cell adhesion molecule C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00047, Pfam:PF07679, Pfam:PF00041. The Down syndrome cell adhesion molecule (Dscam) belongs to a family of cell membrane molecules involved in the differentiation of the nervous system. This is the C terminal cytoplasmic tail region of Dscam.	25.00	25.00	29.90	37.40	19.60	20.20	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.78	0.71	-3.86	2	83	2009-09-14 13:51:33	2009-09-14 14:51:33	3	25	26	0	21	106	0	122.90	86	5.83	CHANGED	tGuuhass.uPEYDDPANCAPEEDQYGSQY.G.YGtPYDHYGSRGShGRRSlGSARN.PssGSPEPPPPPPRNHD.sNSSFNDSKESNEISEAECDRDphsptNYGsstRu...KDthTTEEMRK	........QGGSLYSGPGPEYDDPANCA....PEEDQYGSQYGGPYGQPY.DHYGS....RGSMGRRSI..GSARN.PG.NGS...........PEPPP.PPPRNH.D...MS......N...SSFNDSKE...SNEISEAECDRDHGPR.GNYGAVKRSPQPKDQRTTEEMRK............	0	7	9	18
+12190	PF12356	DUF3643		Protein of unknown function (DUF3643) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 217 and 4852 amino acids in length. There is a conserved TLA sequence motif.	19.40	19.40	19.70	19.50	17.40	15.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-11.05	0.71	-4.91	5	94	2009-09-14 13:52:16	2009-09-14 14:52:16	3	6	62	0	49	100	0	143.50	50	4.10	CHANGED	pVApL+coushsaRCs....s.S.hE.sL.sPSPuHlHCVAAILW+SYEL.VpYDLPsLLop-LFEolYcWSMsL-pspPLKKSVDSLLCSLCYI+PcYFohLLsWMGIpLpssus.......phs.TDDsKcpp...ulTDDSKsAp...hsu.h.p.sspshosLlLsESaLsTLAhACQ	..........................lhth+.s..hthhss..............sh..l.PusualHCVAuILW+oach..lpYDLssLLs....p-LFEhLapWohoLssN.......sLKKAlDSLLCShCaI+Ps.hFolLhsWMGIhsP.s.lpsc.....hphShoDDsKcp-.......uhTDDSKssp.........................usLsLo-SpLuTLAuuSQ..................................................	2	10	14	31
+12191	PF12357	PLD_C		Phospholipase D C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00168, Pfam:PF00614. There is a conserved FPD sequence motif.  This family is the C terminal of phospholipase D. PLD is a major plant lipid-degrading enzyme which is involved in signal transduction.	21.30	21.30	23.80	27.40	19.20	18.10	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.45	0.72	-4.44	66	288	2009-09-14 13:53:00	2009-09-14 14:53:00	3	8	64	0	147	296	0	73.40	46	9.38	CHANGED	l--sFhcPESlECV++VNplA-c.WchYuu--l...s-h.G.HLL+YPlpVspc.GpVssL.PGtEhFPD.stu+llGspo	.....--sFhcPESlECV++VNplA-cpW...chYuu...--l......p-l.G...HLLpYPlpVs.......p-.G.cVstL.PGtEt..FPD.stu+lLGs+.....	0	22	86	118
+12192	PF12358	DUF3644		Protein of unknown function (DUF3644) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 65 and 80 amino acids in length.	21.80	21.80	21.80	22.00	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.46	0.72	-3.71	43	219	2009-09-14 13:53:48	2009-09-14 14:53:48	3	5	217	0	50	180	6	70.60	22	23.26	CHANGED	sl.hhspuWphhL+uhhhpcthc......................hhth.tsGss+shpLppslcp.......s.sps..lt.pNlptLh-hRcp.h	......h.h.ssuaphhh+uhhhpctss...............................hh...ppss.s+shpLppslcc...........scsph.hptsLptlhchRspu......	0	12	31	42
+12193	PF12359	DUF3645		Protein of unknown function (DUF3645) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a conserved HPD sequence motif.	25.00	25.00	27.30	26.20	22.40	17.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.35	0.72	-7.53	0.72	-4.82	27	194	2009-09-14 13:54:36	2009-09-14 14:54:36	3	20	105	0	170	208	11	34.80	53	1.11	CHANGED	ls.sR...phLAVPahuKDsPotpSEFuHPDVlIsLT	...........p.sR......shlAVPacAKDsPStpSEFuHPDVsIlLT..	0	65	114	150
+12194	PF12360	Pax7		Paired box protein 7 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00046, Pfam:PF00292.  Pax7 belongs to a family of genes that encode paired-box-containing transcription factors involved in the control of developmental processes. Pax7 has a distinct role in the specification of myogenic satellite cells.	21.60	21.60	24.10	33.20	19.00	17.70	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.31	0.72	-3.68	12	179	2009-09-14 13:55:18	2009-09-14 14:55:18	3	6	54	0	53	178	0	44.40	70	9.66	CHANGED	uuuDuuSAYsLuosRHuFSuYSDoFhu.ssusuNtMNP.luNGLSPQ	.....suDoSSAYsLsSsRHuFSSYSDSFhs.PouPSNtMNP.luNGLSPQ.	0	2	8	22
+12195	PF12361	DBP		Duffy-antigen binding protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 449 and 1061 amino acids in length. The family is found in association with Pfam:PF05424. There are two conserved sequence motifs: NKNGG and QKHDF. This family is part of the Duffy-antigen binding protein of Plasmodium spp. This protein is an antigen on these parasites which enable them to invade erythrocytes.	25.00	25.00	274.00	273.10	18.50	17.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.99	0.70	-4.90	4	71	2009-09-14 13:55:58	2009-09-14 14:55:58	3	7	5	0	3	82	0	294.20	88	38.23	CHANGED	SpshhQsVcSSpuE.KVQGDSAHGNlNsGttpSTTscAssGsGQNGNQTPAcSsVpcoDhsEuhSAKNVDspK.VoERusDTsuVTsIsEAGKEsLssopupsSEoTV-ususGDGhVpsAshPVhsSENPLVT.aphht.SKDNSD...ssGS......spssEohAssDSsuK..GEstcsQcstpsKus+DoSspSsuTSu...uoGD....shssl-pt.stusP.pt.......s..VGu.......KctpsE-opspKDutTV..........AGGoTss.pcN...DT-NsNlPsssNKQsEGATALStsESLESNESVH+ThssTTHuLENKNGGsEKDhQKHDFhN	SNPISQPVDSSKAE.KVPGDSTHGNVNSGQDSSTTGKAVTGDGQNGNQTPAESDVQRSDIAESVSAKNVDPQKSVScRSDDTASVTGIAEAGKENLGASNSRPSESTVEANSPGDDTVNSASIPVVSGENPLVTPYNGLRHSKDNSD...SDGP.........AESMANPDSNSK..GETGKGQDNDMAKATKDSSNSSDGTSS...ATGD....TTDAVDREINKGVPEDR.......DKTVGS.......KDGGGEDNSANKDAATVVGEDRIRENSAGGSTNDRSKN...DTEKNGASTPDSKQSEDATALSKTESLESTESGDRTTNDTTNSLENKNGGKEKDLQKHDFKS	0	0	0	1
+12196	PF12362	DUF3646		DNA polymerase III gamma and tau subunits C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00004. The proteins in this family are frequently annotated as the gamma and tau subunits of DNA polymerase III, however there is little accompanying literature to back this up.	23.60	23.60	24.20	25.00	23.00	23.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.25	0.71	-10.10	0.71	-4.15	77	299	2009-09-14 13:56:33	2009-09-14 14:56:33	3	3	296	0	103	270	1082	115.70	35	19.43	CHANGED	sthsoFc..cllpLhpppRDltLtsplcpslRLVpa..pPGRIEhp.sssAspsLsscLuptLppWT.GpRWhVolssp..sGt.PTltEpcpstcpthpscAppcPhVpAlLstFPuAcIs-.lR	................s..hsoap..-lVsLsccpRDhtl+htlcssVRLVph..pPGR..l-lphss..sAPpsLss-Lup+LppWT.Gt.RWsVslu..p-....sGt..TlsEtctttcpphhscAcscP.hVtAlLstFPGA+Ih-VR............................	0	30	66	78
+12197	PF12363	DUF3647		Phage protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 119 and 164 amino acids in length. The proteins in this family are frequently annotated as phage proteins, however there is little accompanying literature to back this up or to describe the nature of these phage proteins.	21.30	21.30	22.30	22.90	21.20	20.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.52	0.71	-10.32	0.71	-3.97	39	387	2009-09-14 13:57:27	2009-09-14 14:57:27	3	1	317	0	24	178	4	110.40	28	83.37	CHANGED	plpIsGK....ph-hKFshtFlpclsKphuh..ptt...t..h....phssGhs.tlhsslhp.tss.slschlcsuhhptppph.opccl-phlcp...h-pp..p.hpclhpcllpcl.ppushhKptscphhp	..............lcINGK....ph-lpFshtFlREl-c+hsh....cst....t..h.....phu.G.ls.tlh.ssLhp.tssssls-lhpsAsut.ppph.oppcI-chl-p.....p....pt...p..lcpLhs-lLpEl.sppshs+thlcph....................	0	8	16	21
+12198	PF12364	DUF3648		Protein of unknown function (DUF3648) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 53 and 3115 amino acids in length. There are two completely conserved residues (A and F) that may be functionally important.	20.60	20.60	22.90	22.90	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.59	0.71	-4.18	9	103	2009-09-14 13:58:36	2009-09-14 14:58:36	3	3	12	0	3	85	0	108.20	64	10.89	CHANGED	hSKltuSahSSuhAssusYohSRhWRphsshtsht.............haGs............sthspll+-hsAshs.sshRco.....lFPaolcAhh+t.sthupshspstpsshshhsl.pspusspPphhsu.shhsLCcPPL..........ossA++ulRpuK	.................MSKLGAsF+SSoFAVRSDYhISRIWRshNTlGVLH.............aFGo............tshTpVlKEaSAshPIVPLRKS.....sFPFSVRAAVRAIcAAu+PhssP+usshsshPVhssuGsspPp.lAGh.RhuLCcPPL................................	0	1	2	3
+12199	PF12365	DUF3649		Protein of unknown function (DUF3649) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length.	21.20	21.20	23.20	23.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.84	0.72	-7.01	0.72	-4.41	39	161	2009-09-14 13:59:17	2009-09-14 14:59:17	3	1	142	0	52	149	2	28.00	39	24.75	CHANGED	sFusRSAhRA.WhGlllsuslLuslhhhs	..sFAsRSAWRA.WhGlhlsuhlLuulshh........	0	11	23	37
+12200	PF12366	Casc1		Cancer susceptibility candidate 1 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 216 and 263 amino acids in length. Casc1 has many SNPs associated with cancer susceptibility.	21.30	21.30	21.80	21.30	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.44	0.70	-4.87	25	204	2009-09-14 13:59:59	2009-09-14 14:59:59	3	4	60	0	109	201	0	216.40	19	39.55	CHANGED	hsp.c.lphsphshph+slphchD+LuhauhuFcphhchs...............hpcWthQ.s.ps..Ellhsl-.....oh+sch.haIo..........spuh+uhspchtKphsu+shKhlcI.cP.p-hppLpcthhscslslFsEp-sphYl-ph.hs...KHluh...E.hshcthslpstlhphhRschs+hs.....s+tsIlL............th+..........ssKs.pcss.sp...........h+loP-sssFlcVo.tss-plslht.shts	...........................................................................................ph.h..hp.shth+hlphchD+lu.h.shu......h..p.h.phs.......................hppaphp...s.pp......phl.hphp........pt.hhphp.hhp........................ttht....t.tt........thsst..c..p.h....c............p.t.L.pthhssshplF.pp-t..hhph...h....cphth...p.hshcphshlGulaphshhchs.ps......t+tphll.............h.................................p.ht.t....t.sh......................hh.hs..s.t...h.s.....hltlT.phspplhhht.shh.....................................................	0	25	32	75
+12201	PF12367	PFO_beta_C		Pyruvate ferredoxin oxidoreductase beta subunit C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF02775. There are two completely conserved residues (A and G) that may be functionally important. PFO is involved in carbon dioxide fixation via a reductive TCA cycle. It forms a heterodimer (alpha/beta). The beta subunit has binding motifs for Fe-S clusters and thiamine pyrophosphate.	21.40	21.40	21.40	21.50	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.45	0.72	-4.05	69	635	2009-09-14 14:37:33	2009-09-14 15:37:33	3	2	596	0	197	390	60	70.40	42	24.41	CHANGED	CVoFNKlNTapWa+E+lhpL...-.saDPoD.+ttAhppuhE....s-p.lPlGllYcsc.+soaE-plshh.....ppsPL	..................................................CVTYNK.lNTYDWF............K...........E+Lsplp...........shE..sY.....D.....s...........o...........D....+p....hA.....h..c......plhE........p-s..LspGllYQsc.ppPoYEpplpth...pcps....................	0	74	139	176
+12202	PF12368	DUF3650		Protein of unknown function (DUF3650) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00581. There is a single completely conserved residue N that may be functionally important.	20.90	20.90	21.70	21.40	20.10	19.10	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.73	0.72	-6.96	0.72	-4.45	23	786	2009-09-14 15:50:37	2009-09-14 16:50:37	3	2	782	0	48	308	0	27.80	55	8.66	CHANGED	ECRsHPRNRYVpcHsLS-EElpcRLpsl	.ECRsHPRNRYVpcppLoppEhtcRLssl.....	0	13	23	35
+12203	PF12369	GnHR_trans		Gonadotropin hormone receptor transmembrane region 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00560, Pfam:PF00001. There are two completely conserved C residues that may be functionally important. This family contains the transmembrane region of Follicular stimulating hormone and leutenizing hormone - the two major gonadotropin hormone receptors. These receptors are G protein coupled receptors involved in development and maturation of germ cells in both fecund genders. The transmembrane region is conserved between the two different receptors while the extracellular ligand binding domains are less well conserved.	22.10	22.10	22.60	22.10	20.40	21.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.73	0.72	-3.53	14	158	2009-09-14 15:52:14	2009-09-14 16:52:14	3	24	102	0	24	139	0	60.60	56	13.56	CHANGED	+.+.QhotLHPICN+S.h+pD.D-hspspt....pRposh.D..ssaups.s...s......E..a.DYDL.CpEVVsVsCSPc	...........h..p..othpslCNtS...hpp-hs..spspt........pc.ShAEDt..SuYupGFDhhhs.......E..F.DYsL.CNEVVsVsCSPK..	0	1	3	6
+12205	PF12371	DUF3651		Protein of unknown function (DUF3651)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. This family is frequently annotated as a membrane protein but there is little associated literature to back this up.	21.70	21.70	21.90	22.40	21.60	20.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.99	0.72	-3.97	26	305	2009-09-15 14:06:27	2009-09-15 15:06:27	3	5	99	0	183	275	1	75.30	24	8.61	CHANGED	slsFlPp..phGthcuslhlhT.shGs.hhhtl.........pu.uspsPa+L.....pshhthplshssshs..lslaNPaspsLplscl	..........llFlsp..ppGsl-sslhlpT.shGh.hph.V............................................huhssp......pl..........hhlshsss....lslhNstst.ltl.p..............................................	0	32	49	98
+12206	PF12372	DUF3652		Huntingtin protein region 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF02985. This family is in the middle region of the Huntingtin protein associated with Huntington's disease. The protein is of unknown function, however it is known that a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.	20.90	20.90	21.10	21.30	19.90	20.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.85	0.72	-4.35	16	142	2009-09-15 14:07:37	2009-09-15 15:07:37	3	5	63	0	66	142	0	41.40	43	2.12	CHANGED	hcslhths+.....lh.chlsGphsuuppsssht......psllpDhhhhp	..u.+tllthPK.....Ih.pLs-GlMASGpcusThAl..sshpsllcDLhVlp....	0	11	13	36
+12207	PF12373	Msg2_C		Major surface glycoprotein 2 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF02349. This family is the C terminal of major surface glycoprotein 2 of virulent bacteria. It is a virulence factor antigen.	25.00	25.00	29.60	28.60	21.50	20.00	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.94	0.72	-7.17	0.72	-4.73	17	82	2009-09-15 14:08:36	2009-09-15 15:08:36	3	7	3	0	0	84	0	29.70	54	3.13	CHANGED	ph+LV+Rsh.....ssstVoEtElKAFDhsA.Ahp	.+ltLV+Ruh.....scsuVoEsElKAFDhsuhAhp.	0	0	0	0
+12208	PF12374	Dmrt1		Double-sex mab3 related transcription factor 1	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. The family is found in association with Pfam:PF00751. This family is a transcription factor involved in sex determination. The proteins in this family contain a zinc finger-like DNA-binding motif, DM domain.	21.20	21.20	21.60	21.50	21.00	19.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.45	0.72	-3.62	46	292	2009-09-15 15:40:47	2009-09-15 16:40:47	3	4	110	0	38	292	0	63.10	31	39.59	CHANGED	ELGIspPlsL.uus-shVKsEssus.shh...h-.ups.o.s.....ssuSsusssu+.shpssP.uhsuRsas-usSD	.........ELGIspPlsL.suu-hhlKpEssus.sph..hh-..u.......sS.ops..........s.ssssoss..ss....sh..hps.s.uhssph...tt.s............................	0	1	3	18
+12209	PF12375	DUF3653		Phage protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 112 and 194 amino acids in length.	22.20	22.20	22.20	22.30	21.90	20.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.72	0.72	-3.76	20	109	2009-09-15 15:41:35	2009-09-15 16:41:35	3	5	94	0	19	77	0	76.70	28	50.50	CHANGED	GFph.....ptsc.LlTPEG+plpPp-lthhulhhs.Apc.acphhc.ttts............h....................usllthscshh+p+	........GatF..cpu+.LlTPpG+clsstplcshphphs.sRt.acp...hhp.tcts.............th......................h.lhhlt.shhph.h.................................	0	5	13	17
+12210	PF12376	DUF3654		Protein of unknown function (DUF3654) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 193 and 612 amino acids in length.	25.00	25.00	30.80	30.80	23.80	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.72	0.71	-4.35	15	56	2009-09-15 15:42:41	2009-09-15 16:42:41	3	2	7	0	27	53	0	127.60	42	32.99	CHANGED	IpphPusLScEEK++ccchLppIKEYGEpLsTcEKQ-cIlcAQKIlCDACc.IWt+.cE-RhthlhttaSp+LpLKhhtus....sch.chchsLhthlDHchLlsAacEYt.hDVsuELV+QhhL..csc-IDcc.lscs...V	..........t.ssthsp-E+ch..c.hpphKcaGtpLpspE+hcpIlEsEKIVCsAC+cIChsL+EEELhGLhAEGuh+KsLKtph.u-......cchpcttY.....LEhthlDpplLLDAH.+EaG.t-Vs+ELV+QhLLGKcG+-ID++Yls+VAssV............	0	27	27	27
+12211	PF12377	DuffyBP_N		Duffy binding protein N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF05424. This family contains the N terminus of the Duffy receptor binding domain.	25.00	25.00	28.70	73.30	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.99	0.72	-3.76	3	77	2009-09-15 15:43:41	2009-09-15 16:43:41	3	6	5	0	3	84	0	61.50	92	9.21	CHANGED	cEEKDGEHKTDSKTDNGEGsNNLVMLDYDTSSNGHPAGTlDNVLEFVTEHEGNSLcNSSKGGN.PYD	...........GEEKDGEHKTDSKTDNGKGANNLVMLDYETSSNGQPAGTLDNVLEFVTGHEGNSRKNSSNGGN.PYD	0	0	0	1
+12212	PF12378	CytadhesinP1		Trypsin-sensitive surface-exposed protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 67 and 79 amino acids in length. This family contains trypsin-sensitive surface-exposed proteins called cytadhesins. Cytadhesins are virulence factor proteins which mediate attachment of bacterial cells to host cells for invasion.	25.00	25.00	25.10	31.60	23.50	22.30	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.01	0.72	-4.03	8	115	2009-09-15 15:45:13	2009-09-15 16:45:13	3	3	12	0	13	113	0	70.30	42	13.09	CHANGED	hpoTshas.ct+PsW.........NshsGFssssoppptpu.pcps-..sSuPIuLPa-sYhsNlGNlhhhspuVllFGGN	...oTsphs.stcPpa.........NshsGFGlsGs.....uPpcasE..cupsPlpls.psa.sNlhsllhlspsVlhatt......	0	11	11	11
+12213	PF12379	DUF3655		Protein of unknown function (DUF3655) 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF08716, Pfam:PF01661, Pfam:PF05409, Pfam:PF06471, Pfam:PF08717, Pfam:PF06478, Pfam:PF09401, Pfam:PF06460, Pfam:PF08715, Pfam:PF08710.	25.00	25.00	56.30	55.20	24.80	23.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.47	0.72	-4.05	3	173	2009-09-15 15:46:42	2009-09-15 16:46:42	3	5	67	2	0	150	0	68.80	93	1.17	CHANGED	MYCSFYPPDEEEDCEEYE-EEElsEETCEHEYGTEDDYKGLPLEFGASTEIlQVEEEEEEDWLDDAlEAc	MYCSFYPPDEEEE.DDAECEEEEIDETCEHEYGTEDDYQGLPLEFGASAETVRVE.EE.EEEDWLDDTTEQS.....	0	0	0	0
+12214	PF12380	Peptidase_C62		Gill-associated viral 3C-like peptidase	Coggill P	pcc	MEROPS_C62.001	Family	a positive-stranded RNA virus of prawns, that has been called yellow head virus protease and gill-associated virus 3C-like peptidase. The GAV cysteine protease is predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, pp1a and pp1ab. This protease employs a Cys(2968)-His(2879) catalytic dyad.	18.80	18.80	19.60	643.90	18.20	18.70	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.85	0.70	-5.58	2	13	2012-10-02 13:45:52	2009-09-15 16:57:05	3	3	2	0	0	15	0	284.00	95	6.70	CHANGED	FLVGLVTHEVpTGNsTpVEDLNKHPYNKYRpNIVRVYGERGDLNGFLSGK.LaFPRHIFDoCTDNTLTRHIRVTKGEtTHDIELLSEEYDATPFIKs-SPFAEAT.LKFuKLQRTQasYFVTADDIRlGSMSsDGYHNISTKDGDCGSllFDHLtNVVGAHIVGIusIPPVNGALTWNsEpEhLCGPNsDYDaDPpKVsPPKVWPVEslTALSTlLNQLNYVTGDAFTTPKLPTNYQLlGCETLDQYVNApNLVTGQFPQIKEALDDFINGYVANLQRGsEAYN	FLVGLVTHEVNTGNNTRVEDLNKHPYNKYRSNIVRVYGERGDLNGFLSGKFLYFPRHIFDSCTDNTLTRHIRVTKGEETHDIELLSEEYDATPFIKI-SPFAEATVLKFGKLQRTQYAYFVTADDIRVGSMSsDGYHNISTKDGDCGSLLFDHLHNVVGAHIVGIASIPPVNGALTWNAEKEMLCGPNDDYDYDPEKVGPPKVWPVESITALSTILNQLNYVTGDAFTTPKLPTNYQLIGCETLDQYVNARNLVTGQFPQIKEALDDFINGYVANLQRGTEAYN	0	0	0	0
+12215	PF12381	Peptidase_C3G		Tungro spherical virus-type peptidase	Coggill P	pcc	MEROPS_C03.024	Family	This is the protease for self-cleavage of the positive single-stranded polyproteins of a number of plant viral genomes. The protease activity of the polyprotein is at the C-terminal end, adjacent to the putative RNA polymerase.	20.70	20.70	22.20	21.20	20.10	19.30	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.40	0.70	-5.11	3	29	2012-10-02 13:45:52	2009-09-15 16:57:36	3	4	11	0	0	48	0	225.10	36	9.79	CHANGED	cKGLDKDPNMVoILos+LssISCVIlNlTPsRpAYhNVlRLCGTaVVCPAHYLEALEE-DTLYFICFSllIKLpF-PcRVTLVNoaQDLVVWDLGNSVPPSIDsLcMIPTl-DWD+FQDGPGAFuVTKYNu+aPTNYINTLDMIERIRANTQNPTGhYcMhGSpHTITTGLRYQMaSL-GFCGGLILRAsTsMVRKIVGlHVAGSpNHAMGYAECLlQEDL+pAIs+LuhD	..........................................h......D.sh.pLlss+.hssh.pl.hlst.ssh.h.hhsGLFlpushhLhPuHhlsh.lsppcp..I...hh.h..c..sl..h+....V.h.cs.+K.V.slV.N.....u.......p.Esslhsh.s.p.Vst+pDllc.aFtsu-shspa+t..s.ps...sLssh+a...Stc..s.spalps.L.ts-+h..-A.....D+Phohs-sppGpYhlRQGLEYphsohsGDCGuPllls-opshRKIsGlHVAGhst..p...u...+..uYAEoITQcDLhpAhppl...sso..................	0	0	0	0
+12216	PF12382	Peptidase_A2E		Retrotransposon peptidase	Coggill P	pcc	MEROPS_A02.051	Family	This is a small family of fungal retroviral aspartyl peptidases.	21.10	21.10	21.60	22.40	20.50	21.00	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.47	0.71	-4.37	2	4	2012-10-02 15:32:34	2009-09-15 16:58:21	3	1	2	0	3	7	0	137.00	90	10.28	CHANGED	KpNsTpsRp.+KTNVSRIEYSSppFhpap++RYEMVLQAcLP-FKCSIPCLIDTGAQsNlITEETVRAHKLPTRPW.pSVIYGGVYPsKINRKThKL.IsLNGISIKTEFLVVKKFSHPAAISFTTLYDNNIEISSS	........................KNNTTNSRNLRKTNVSRIEYSSNKFLNHTRKRYEMVLQAELPDFK.CSIPCLIDTGAQANIITEETVRAHKLPTRPWSKSVIYGGVYPNKINRKTIKLNISLNGISIKTEFLVVKKFSHPAAISFTTLYDNNIEISSS..............................	0	3	3	3
+12217	PF12383	SARS_3b		Severe acute respiratory syndrome coronavirus 3b protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 32 and 154 amino acids in length. This family contains the SARS coronavirus 3b protein which is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells.	25.00	25.00	59.30	59.30	18.50	18.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.11	0.71	-4.29	3	70	2009-09-15 16:01:23	2009-09-15 17:01:23	3	1	66	0	0	16	0	118.70	96	99.22	CHANGED	MMPTTLFAGTHITMTTVYHITVSQIQLSLLKVTAFQHQNSKKTTKLVVILRIGTQVLKTMSLYMAISPKFTTSLSLHKLLQTLVLKMLHSSSLTSLLKTHRMCKYTQSTALQELLIQQWIQFMMSRRRLLACLCKHKKVSTNLCTHSFRKKQV	MMPTTLFAGTHITMTTVYHITVSQIQLSLLKVTAFQHQNSKKTTKLVVILRIGTQVLKTMSLYMAISPKFTTSLSLHKLLQTLVLKMLHSSSLTSLLKTHRMCKYTQSTALQELLIQQWIQFMMSRRRLLACLCKHKKVSTNLCTHSFRKKQV	0	0	0	0
+12218	PF12384	Peptidase_A2B		Ty3 transposon peptidase	Coggill P	pcc	MEROPS_A02.022	Family	Ty3 is a gypsy-type, retrovirus-like, element found in the budding yeast. The Ty3 aspartyl protease is required for processing of the viral polyprotein into its mature species.	21.20	21.20	21.40	21.20	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.05	0.71	-4.94	2	18	2012-10-02 15:32:34	2009-09-15 17:03:42	3	6	11	0	13	32	0	140.50	27	17.31	CHANGED	VLsDhELESKDpppL.IpohPIVHYIAIPEMDpTAEKpIKIpNTKlKTLFDSGSPTSFIRRDhVpLLph.ha-TPPLRFRGFluTcSssTSEAVTlDLplssLQIslAAYlLDpMDYQLLIGNPILRRYPKlLaTlLNT+psssu.KPKsY+SEsVN.V+shSAGNRGNsRNhp.SF	...................t........................ll..h....htpsh.hplphpssplcs.LhDoGSPTSFIRpDllpcLcLphapsPshch+...Ghlus.p.st.ospAsplslphsshphslsAYVh-t..hchpllIG.PhLc+aPpl.........h.s.hhp................................................................................	0	3	6	13
+12219	PF12385	Peptidase_C70		Papain-like cysteine protease AvrRpt2	Coggill P	pcc	MEROPS_C70.001	Family	This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis [2]. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2 [1].	18.80	18.80	18.80	18.80	18.70	18.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.07	0.71	-4.55	4	20	2012-10-10 12:56:15	2009-09-16 12:43:07	3	5	19	0	6	44	0	158.90	28	25.46	CHANGED	sPhhGGhF.........-ouGSSuopuuSphh.............VPYlsQtspR.GCWYAsspMlua.hpsGP..RLGLPtLY-u.pG.PptLpt.pDl.chh+sEsLtplslPsscpaos-cLuALLscHGPIhhu...hcoP..sDsh..Hh.VLTGID+.sssIpaHDPctGPshsMsLshhNpthsWp.sH	...................................................s................................................h.Qpspt..uCWhAsssMlhtahc...s.....t..s..........+lG.s.L..Ycu.p...G.hPtthpt...p-h..........tchhpstuL.ps.ls.P.......tsps....aospphtsLLpcaGPlhhu...hcoP..uss.a....HshVl..TGIcp...-...s......c..ul.hhDP.....pG.p.h...shp.h..spt....................................	0	1	2	4
+12220	PF12386	Peptidase_C71		Pseudomurein endo-isopeptidase Pei	Coggill P	pcc	MEROPS_C71.001	Family	This peptidase has the catalytic triad C-H-D at the C-terminal end, a triad similar to that in thiol proteases and animal transglutaminases. It catalyses the in vitro lysis of M. marburgensis cells under reducing conditions and exhibits characteristics of metal-activated peptidases.	20.80	20.80	20.80	22.20	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.09	0.71	-4.75	3	4	2012-10-10 12:56:15	2009-09-16 12:58:37	3	2	4	0	1	24	6	145.50	33	55.48	CHANGED	ssssc-TT-l.....p-KlGsF+DATSLYs+V++RCKYKYYYNDQsPN+EAlpKMsT.sGINCTDACQLFp+VlEuLGYsV+IEHVRVRCNDGKWYGHYhLRVuGpELss.......GTlWDY..VSATKTGRPLGuPCCosGh...QHLGWGIVSPlYD	...................s..hsp.spch.....hchh.Gthp.shsphhshlp+RptYpaYYNsQhss+cslp+hhs.pGlNCTDusQLFh+lhcuLGYsVph.HV+.sR...ssGp..GHhh..LR..l..ttp.chs...........GssW.Y..suAstsGps..luushCpsGh....c.uW.IhoslYp..................................	0	0	1	1
+12221	PF12387	Peptidase_C74		Pestivirus NS2 peptidase	Coggill P	pcc	MEROPS_C74.001	Family	The pestivirus NS2 peptidase is responsible for single cleavage between NS2 and NS3 of the bovine viral diarrhea virus polyprotein, a cleavage that is correlated with cytopathogenicity [1]. The peptidase is activated by its interaction with 'J-domain protein interacting with viral protein' - Jiv. [2, 1].	20.90	20.90	20.90	79.00	17.90	20.10	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.23	0.71	-5.15	6	178	2009-09-16 12:02:53	2009-09-16 13:02:53	3	22	28	0	0	196	0	181.60	71	6.17	CHANGED	WLG+lsYKRVsoVY-lDpStEGVYLFPS+QKssutsuhlLPLL+AlLISCISSpWQhhYLhYLllElsYYhHRKIIEEIAGGTNhlSRLlAALIElNWuhD-EEoKGLKKFFlLSuRV+NLIlKHKVRNEsls+WatEEElYGMPKllollKAATLSKsKHCILCTVCEsR-WKGssCPKCGRpG.PIoCGMTLADFEE+	...............WLhthsYKplssl.Y-lDpuGEGVYLFPS+QKssp.huhhLPLl+AhLISCISsKWQhlYhhYLhh-h.YYhH+KlI-EIuGGTNhlSRllAALIElNWuh-pEEsKGLKKFaLLSuRl+pLIIKHKVRNEsVspWaG-EElYGMPKllolIKAuTLSKNKHCIlCTVCEuR-W..+Gus..CPKCGRaG+PITCGMTLADFEE+.	2	0	0	0
+12222	PF12388	Peptidase_M57		Dual-action HEIGH metallo-peptidase	Coggill P	pcc	MEROPS_M57.001	Family	The catalytic triad for this family of proteases is HE-H-H, which in many members is in the sequence motif HEIGH.	21.00	21.00	21.00	21.00	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.37	0.70	-5.00	5	69	2012-10-03 04:41:15	2009-09-16 14:03:59	3	10	40	0	35	188	15	198.00	31	60.86	CHANGED	IhIEuDIshTcKELNcLp..u.ss-sKQYRTsNLVssusRTITIlGYTGssQ.uLoupupTALscAVNNYNsl.GhsIsF.RLTFGTNaQNuDMVVYsNolNNPSGo....GGuAGFPsusGcPsKFVQI....YsLcssSTNVsEH.VITHEIGHSIGFRHTDYasRp.SC..GpsGNEGoGGlGAVaIPGTPTGpDsoSlMQACFSsGsDGsFNoNDITALLsMY	........................................................................................................lttDhhho.pt.pp...h............t.........s.....t..cQYRTsslV.....s.t.s.p....sI.slhs.s.............uhs.s.p.hpsuLpp....AlspYNsl..sLslsF...pht.h.....ss.s....h.t....s.t.sh..s..l.h..p.s.sss...sGs.....G..us..A.G.F.P........o..s..Gp..P.....a....p..h.lpI...........h.u.h..s....s....h....s....s....s....s..h..p+....VlsHElGHslGhRH.T.D....ahs.Rp...SC....Gps..s.sEGsu...ssGAltIPGTPos...h..s..s.sSlM.u.Chss.s..psstFsssDhhALphhY.......................................................	0	14	22	31
+12223	PF12389	Peptidase_M73		Camelysin metallo-endopeptidase	Coggill P	pcc	MEROPS_M73.001	Family	\N	21.40	21.40	21.40	21.40	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.35	0.71	-4.85	2	432	2009-09-16 15:08:38	2009-09-16 16:08:38	3	3	167	0	49	281	4	171.20	43	87.42	CHANGED	M..oLKKKLGMGlASAsLGhuLlGGGTFAaFSDKEVSNNTFAsGTLDLsLsPpTlVslpsLKPGDoVcKEFhLcNpGoLsIKcVhLtTcYsVcDVKtDNt.-DFGKHlKVpFLhNhDKppp.VhETsLscLptss.shlspDlhA..WsEK.GlpAGppDhhhVpFEFVDstKDQN.FQGDpLpLpWTFsApQtsGEpK	.................M...olKKKLGMGlsoAs.L...Glu..L.l..GG...GTaAaF..S.Dp.E.s.S.s.N..TFAAGT..LDL.sl.................s...P....p.....s.....l.....l..s.............l.........p.........sL..K.......PGDpl.cK.pFpLpN.pGo.Ls.I.c.cV.hL..tTcY...s.V....pD..sK...t..s..N.t.........-DFGcHlcV.pFLh..Nh......D..K...........p......p......p.l..hpTT..Ls...cLpt..s.p...h...h..tp....cl......t......h..t.E.t....G.ltsGpp.DhhhV.FpF...DstpD......Q.......N.FQGDpLpLpWTFpu.QttGpp+...................................................................................................	1	12	34	41
+12224	PF12390	Se-cys_synth_N		Selenocysteine synthase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF03841.  There is a single completely conserved residue P that may be functionally important. This family is the N terminal region of selenocysteine synthase which catalyses the conversion of seryl-tRNA(Sec) into selenocysteyl-tRNA(Sec).	21.70	21.70	21.80	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.20	0.72	-7.68	0.72	-3.86	134	925	2009-09-16 15:44:25	2009-09-16 16:44:25	3	5	916	0	183	611	49	39.90	44	8.67	CHANGED	hRplPulDplLppsthtsh......................lpphuRshVhcslRphl-phR	...appLPulD+LL+-s..shhsL......................h-pYG+otVl-hLRphLDcAR.................	0	66	115	155
+12225	PF12391	PCDO_beta_N		Protocatechuate 3,4-dioxygenase beta subunit N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00775.  There are two completely conserved residues (Y and R) that may be functionally important. This family is the N terminal region of the beta subunit of protocatechuate 3,4-dioxidase. This enzyme utilizes a mononuclear, non-heme Fe3+ centre to catalyse metabolic cellular reactions.	21.60	21.60	21.90	24.20	19.80	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.66	0.72	-4.52	79	491	2009-09-16 15:49:27	2009-09-16 16:49:27	3	3	474	172	150	420	62	35.90	41	14.71	CHANGED	ahtRDtsh.HPPthtPsY+oSlhRuPppsLlsl....ssol	...............tRDhsh.HP.sthsPsYKoSVLRuPppsLlul...ppo.........	0	29	77	115
+12226	PF12392	DUF3656		Collagenase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF01136.	22.10	22.10	22.60	22.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.29	0.71	-4.05	199	1248	2009-09-16 15:51:28	2009-09-16 16:51:28	3	4	1215	0	283	989	60	120.40	32	17.09	CHANGED	la.+spDpphtcpl.cp..........stp++lslph.plp..hc.....hsps........hplplp..............s.tp.u...h.....psp..........................sps....shshptApppshsp-plccpLu+lGsTsFph..............pp..lplp.h..............stshFlPsStLNplRRcul-pLppthhtsh	..................................................................................................................RshDpphpptL.+p..........sucR+lsVcl..pls......t........ht-t...............LhLols................s...-c.G....s.......slo..............................................h.s.h....-.s...h-pApssths....hssL....cctLu.KLGpT..ahs..............cc..lpls...l..............ss.slFlPsShLNphRR-Al-hLctsRltt................	0	108	198	246
+12227	PF12393	Dr_adhesin		Dr family adhesin 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF04619. This family is the Dr-family adhesin expressed by uropathogenic E. coli.	25.00	25.00	28.00	28.00	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.39	0.73	-6.50	0.73	-3.65	5	56	2009-09-16 15:52:41	2009-09-16 16:52:41	3	1	2	0	0	56	0	21.00	67	13.14	CHANGED	MKKLAIMAAsSslhssSTAHA	MKKLAIMAAsShlhAsSoAHA	0	0	0	0
+12228	PF12394	DUF3657		Protein of unknown function (DUF3657) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF05057.	21.80	21.80	22.40	22.70	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.98	0.72	-3.90	39	350	2009-09-16 15:53:31	2009-09-16 16:53:31	3	8	98	0	200	384	1	62.30	29	8.76	CHANGED	lpl-Lhas-hhpssp.............................hptlustshpl..pstptl+ca.sslhF......DhhHhshlss.slassll	............................lpLhasph.psss.................................................hhus+sLtlp.+hphG...l++a.sslhF......Dh.Hhshlul.slatsLh......	0	52	75	126
+12229	PF12395	DUF3658		Protein of unknown function 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF08874. There are two completely conserved residues (D and R) that may be functionally important.	20.60	20.60	22.30	22.10	19.60	20.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.13	0.72	-4.51	40	322	2009-09-16 15:54:13	2009-09-16 16:54:13	3	3	272	0	72	276	16	110.90	28	38.04	CHANGED	lhcthpptp.lo.pctppLtpEWpplpppsu.LRlWcss.plpSspc.saaDshIlc.........psss-atpus+llGplhup....h...pph.lu......DsFltaRl+pLlppGhlchcGsht.shcphpl	.....................h..tth.tht.lostchtphttEWpplpppss.LRlWpss.plpSs.pc.shaDphIlc..........ts.s.p-ahp..AscllGpshut....s.......cth...lu......DsaltaRl+pLlppGhl-hpGshs.thp.hp............................	0	20	41	54
+12230	PF12396	DUF3659		Protein of unknown function (DUF3659) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 70 amino acids in length.	22.10	22.10	22.20	22.90	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.23	0.72	-4.30	116	553	2009-09-16 15:55:19	2009-09-16 16:55:19	3	17	61	0	480	572	2	65.10	35	43.00	CHANGED	husLcG.hpVs+tGpllD.ssGpslG+llEG..Dscc...Ls..G+p...V.D-cGcIlDcsGsllG+sEhl..s........pptp	.........ssLpG.hpVs+sGpVlD.psGphlG+llEG....Dscc...Ls.....G+p.......l.D-cGcllDc.sGsllG+sEhl.t....tt..p............	0	80	213	374
+12231	PF12397	U3snoRNP10		U3 small nucleolar RNA-associated protein 10 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF08146. This family is the protein associated with U3 snoRNA which is involved in the processing of pre-rRNA.	22.00	22.00	22.00	24.40	20.80	21.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.48	0.71	-4.16	67	281	2009-09-16 15:56:45	2009-09-16 16:56:45	3	8	238	0	201	271	1	121.50	21	6.72	CHANGED	-shl.plL.Phl.cult.ppss........DhphuuYhllshLus+ssLsspllpuLhcslspshptpst........pp..............uLhsLs..............hlh.....ppp.sstp.............lsppshctlhph.s.....hsphLspl.spphpl..sphlhslltuh.l	...............................sllspllPhltcuLp.sphs........-hphusYMlls.Lus+ssLpcsllsuLhcplhpshsppst..........ps..............uLhs.Lh..............hLh............Qpp..p.sp.p................Lspcshpt.Lh..ph.s.......lhshLppl.upphsl....sphltshh.sh........................................................................	0	62	106	165
+12232	PF12398	DUF3660		Receptor serine/threonine kinase 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00954, Pfam:PF01453, Pfam:PF00069, Pfam:PF08276. There is a conserved ELPL sequence motif.	25.00	25.00	27.20	26.10	23.60	22.00	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.94	0.72	-4.09	34	150	2009-09-16 15:59:03	2009-09-16 16:59:03	3	12	24	0	15	168	0	41.50	50	5.90	CHANGED	ussIs..ppRsQsLl.MNthVl....SS++p...lS.tEN+o.E-LELPLhEa	......ATsIss.ppRsQsLl.MN.....thVl....SS+Rp...lS.tEN+s.E-LELPLhEh.	0	4	8	10
+12233	PF12399	BCA_ABC_TP_C		Branched-chain amino acid ATP-binding cassette transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00005. There is a conserved AYLG sequence motif. This family is the C terminal of an ATP dependent branched-chain amino acid transporter.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.19	0.72	-6.41	0.72	-4.21	827	8057	2009-09-16 16:01:50	2009-09-16 17:01:50	3	14	2852	0	2574	6299	2877	22.90	46	7.99	CHANGED	chIAcGsPp-lpssPcVlcAYL.G	........llAcGoPp-lpssscVhcAYLG.....	0	633	1531	2091
+12234	PF12400	DUF3661		Vaculolar membrane protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 123 and 138 amino acids in length.	22.00	22.00	25.00	24.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.85	0.71	-4.05	49	275	2009-09-16 16:04:10	2009-09-16 17:04:10	3	5	208	0	206	258	1	124.00	35	39.14	CHANGED	CsaYhlNlllDo...TlGlhllah....hlphlsplhph....hthpplc.SGpY.....................................t.PphpsahpQhhlYhhslhhhKhhlhllhhhh....hlthluphlLsa..hcttsp.lplhhVMhlhPllhNslQaallDshI+pp	.....................................................................CshYhlNhllDs........TlGl.llal....hl+hlstlsph.................thp..s.....lc..GpY.................................................................................GsPPpstsWltQshlYhhhlhhhKhslhlllhhh....hhtpluphlLsa..hc...s..Pp.lplhhVMllhPhlhNslpaallDshlpp.....................	0	66	107	164
+12235	PF12401	DUF3662		Protein of unknown function (DUF2662) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00498.	25.00	25.00	27.90	27.50	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.46	0.71	-10.26	0.71	-3.93	76	515	2009-09-16 16:04:50	2009-09-16 17:04:50	3	3	496	1	146	383	83	114.90	32	36.99	CHANGED	Ls+hEptlEphlpusFu+sFpup..lpPsElsptLcREh-spsthluts+hl.sPNtaslpLussDacplss...h.tssLspElsshlpcaupppsashs.GslpVphpp..sssLcsG.pa+lpu	.............lp+hE+plEssVsssFA+sFp.up..lpPsElsutLpREh-spsphlups.+sl..sPNcahlpLSspDa-+Lssh...sctLssEluspLpcaspcptashh..GslhVca-t..sssLpsG.paclp.............	0	54	113	138
+12236	PF12402	nlz1		NocA-like zinc-finger protein 1	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 42 and 57 amino acids in length. There is a conserved GAY sequence motif.  There is a single completely conserved residue G that may be functionally important. Nlz1 self-associated via its C terminus, interacted with Nlz2, and bound to histone deacetylases.	21.20	21.20	26.30	24.40	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.77	0.72	-3.62	7	173	2009-09-16 16:05:48	2009-09-16 17:05:48	3	2	89	0	44	126	0	51.50	68	10.89	CHANGED	AuhsYPGSlsGAYAGYPppals...uLDssK..uSLVuuQh.....uohGss.K.suuushsG	...AGMoYPGSLAGAYAGYPppFLPHG.shD.tK..uSL.VsAQL....AuSLGC.S....AGSSPLAG.....	0	3	7	18
+12237	PF12403	Pax2_C		Paired-box protein 2 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00292. This family is the C terminal of the paired-box protein 2 which is a transcription factor involved in embryonic development and organogenesis.	28.10	28.10	42.50	29.80	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.73	0.71	-4.43	11	295	2009-09-16 16:06:57	2009-09-16 17:06:57	3	5	51	0	109	199	0	101.30	53	28.58	CHANGED	suspsssshsuhuchusshuphpS.slhsGR-hu.STTLPGYPPHVPPTGQGSYsoSoLAGMV.PGu-FSGNPYSHPQYooYNEAWRFoNPuLLuSPYYYSsAuRss.PPTuATAYD+	...............................st......s.sssschGushst.p.oh.sl....loGRDMA..STT...LPGYPPHVPP...oGQGSYso.SoLu.G...MV..PGS-FSGsPYSHPQYoo.Ys-u....W...RFs.NP..u..LLu.SPYY..YSussRsuss....sssAs..AaD............................................	0	5	11	57
+12238	PF12404	DUF3663		Peptidase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00883. There is a conserved WAF sequence motif.	25.00	25.00	33.40	31.60	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.62	0.72	-4.20	55	805	2009-09-16 16:07:38	2009-09-16 17:07:38	3	3	792	0	98	412	11	76.90	63	18.01	CHANGED	MplpLSppsAsupWGcpAllSFsssuAsIH.....L....ssscsLppIQ+AARKLcuQGIppVpLsG-sWcLEppWAFhQGFtss	..M+ITLSTQPADARWGEKAshShNs.DGlTlHL.....NGsDD..LGLIQRAARKIDG.GIKpVpLoGEGWDh-+CWAFWQGY+uP..	0	9	32	66
+12240	PF12406	DUF3664		Surface protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 131 and 312 amino acids in length.	23.00	23.00	23.50	121.10	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.71	0.72	-3.40	5	53	2009-09-16 16:09:15	2009-09-16 17:09:15	3	3	4	0	1	50	0	100.20	81	54.80	CHANGED	DRQLNPIDFDPNDDQQPLDPNQLIDQtEQSQEPTQQEPIEPQQPTQPuT.EPEELEPETVTVEVP.EPVTSEE...PKE.........SoQTEEsTETQDsKpE.PTpQPVDEPP	DRQLNPIDFDPNDDQQPLDPNQLhDQhEQS....QEs....TQQEPIEPQQPTQPST.EPEEL-PETVTVEVP.EPVTSEE...PKE............SDQTEE.QKHEEPEAS.PsPEPVDEPs	0	0	1	1
+12241	PF12407	Abdominal-A		Homeobox protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00046. This family is a homeobox protein involved in differentiation of embryonic cells to form the abdominal region.	25.00	25.00	26.20	33.70	19.80	18.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.06	0.72	-4.42	5	126	2009-09-17 12:02:55	2009-09-17 13:02:55	3	2	103	0	24	91	0	23.90	83	12.42	CHANGED	ELRAVKEINEQARREuc..EcE+c++	.ELRAVKEINEQARRERE...EQDhMK+........	0	8	11	21
+12242	PF12408	DUF3666		Ribose-5-phosphate isomerase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF02502. There are two completely conserved residues (D and F) that may be functionally important.	25.00	25.00	31.10	30.20	21.00	16.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.34	0.72	-4.86	37	553	2009-09-17 12:03:37	2009-09-17 13:03:37	3	2	544	19	66	225	3	48.30	52	22.79	CHANGED	sssh+.shlssL+slDQ-LlKsAluGc+FQ-hFFsNCpspcIssYV+sl	....thsh+.shlshL+sID.-hlKsslSGt+FQchFFENCQ-cEltAal+pl..	0	14	33	52
+12243	PF12409	P5-ATPase	P_ATPase;	P5-type ATPase cation transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with Pfam:PF00122, Pfam:PF00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.	21.70	21.70	21.90	24.20	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.38	0.71	-4.25	66	485	2009-11-19 17:32:02	2009-09-17 13:04:37	3	23	233	0	321	463	0	118.50	21	10.19	CHANGED	-D..hhl.sIsGY+sshh+..hhlahhhslhThGlhaLlh+WhP+a+lphhsptssLtcA-..aVl..lE..........spas...phplhpVpp.....phascshSshhs.spp...................h.hspppss....tlsplRhhpYR	..........-.ph.plhGYcpshh+..hhlhhhhslhohG......lhh.L.lh+WhP.cWpVphpsp...s.....s.Lpc.A-.....hVl..lp......................................spap...............phhh.tpVpp................h.h.sp....th....t..........................................................................................................................	0	115	158	251
+12244	PF12410	rpo30_N		Poxvirus DNA dependent RNA polymerase 30kDa subunit 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 193 and 259 amino acids in length. The family is found in association with Pfam:PF01096. There are two conserved sequence motifs: GIEYSKD and LRY. This family is N terminal of the 30 kDa subunit of poxvirus DNA-d-RNA-pol. It has structural similarity to the eukaryotic transcriptional elongation factor SII.	25.00	25.00	53.40	52.80	21.10	19.60	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.51	12	114	2009-09-17 12:05:32	2009-09-17 13:05:32	3	2	83	0	0	76	0	133.60	70	60.24	CHANGED	pDlccllp+YVs-pscspcLlpWAp-pAs+aYl+NIsNTK.SNIEETKF-PtNNIGIEYSKDsKNKLSYRNKP.It..TNh-YpDlCshI+sTNGsEK-hLRYlLFGIKCl+tGVEYsIDclpDhsY.ccYFNVLDcKaN	...DIc-llh+YVc-.uplc-llcWAh-KuSKaYI+NIhNTK.SNIEETKFEs+NNIGIEYSKDSKNKLSYRNKP.Is..TNh-Yp-lCshI+sTsGTEKEhLRYlLFGIKClpKsVEYNIDcI+DlsY.p-YFNVLDcKYN.	0	0	0	0
+12245	PF12411	Choline_sulf_C		Choline sulfatase enzyme C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00884. There are two completely conserved residues (R and W) that may be functionally important. This family is the C terminal of choline sulfatase, the enzyme responsible for catalysing the conversion of choline-O-sulfate and, at a lower rate, phosphorylcholine, into choline.	21.30	21.30	29.60	24.20	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.74	0.72	-4.14	37	292	2009-09-17 12:09:02	2009-09-17 13:09:02	3	6	284	0	123	283	111	54.00	51	10.51	CHANGED	cpcVlpSQpRR+lVas......AL..ppGphtsWDaQPh.pDuSppYhRNHhc..LsslEttuRa	...cppVltSQRRRRlVap......AL..pp..Gpht.sWDaQPh.pDASpcYMRNHh-..LDsLEppuRF..........	0	18	54	88
+12246	PF12412	DUF3667		Protein of unknown function (DUF3667)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. There is a single completely conserved residue P that may be functionally important.	21.80	21.80	21.80	21.80	21.50	19.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.59	0.72	-7.99	0.72	-4.65	78	186	2009-09-17 12:10:03	2009-09-17 13:10:03	3	5	129	0	78	203	27	46.20	33	13.02	CHANGED	Du.+hh+TlhtLhh+PGplsccYlsGc..Rt+YlsPhphalhsuhlh........Fl	...Dsphh+TlhtLlh+PGplsccYlsG+..RhcYhsPhphalh.huhlhh..........	0	39	65	76
+12247	PF12413	DLL_N		Homeobox protein distal-less-like N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.	25.00	25.00	26.50	25.60	23.50	22.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.41	0.72	-2.94	20	283	2009-09-17 12:10:48	2009-09-17 13:10:48	3	2	148	0	84	168	0	74.10	45	33.67	CHANGED	p-SPTLPESTATDsG.YYSspts......HsYhss.....psY.upslN.sY.......Qa.phsGlsus.usYu.sK.sYs....Y.suuY...+QY.GsYsRssssssps	.....p-SPTLP.SosTD.s..YYss..........tasuu......uPY..tpls.sY........QY.phsuhuu.........ssYs.AK..uYs.h...a.suoY...t.pY.GuYupssSsss..s.............	0	4	11	37
+12248	PF12414	Fox-1_C		Calcitonin gene-related peptide regulator C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with Pfam:PF00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.	25.00	25.00	35.30	30.60	22.20	16.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.47	0.72	-3.58	6	257	2009-09-17 12:11:22	2009-09-17 13:11:22	3	4	42	0	88	228	0	87.20	67	26.35	CHANGED	sVPuFPYPs...sss...suuAaRGutL.RGRuRsV....YsshRAAsP...PsulPuYsGVV.YQDGFYGA-.lYGGY.AAYRaAQPAo........AssAAYSDuYGRVY.sA.DPY	............................................................h.lPGFPYPs...Ass.......sAAAaRGAHL.RGRGRs.V....YsshRAA.P...PssIPAYsGVV.YQDG.FYGA-...lY....GGY...A........AYRYAQPss.............AsAAA......YS...........D.uYGRVY..sA.DPY................	0	4	11	37
+12249	PF12415	rpo132		Poxvirus DNA dependent RNA polymerase	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF04566, Pfam:PF00562, Pfam:PF04567, Pfam:PF04560, Pfam:PF04565. This family is the second largest subunit of the poxvirus DNA dependent RNA polymerase. It has structural similarity to the second-largest RNA polymerase subunits of eubacteria, archaebacteria, and eukaryotes.	25.00	25.00	26.40	40.80	19.80	17.10	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.71	0.72	-7.02	0.72	-5.00	13	82	2009-09-17 12:12:17	2009-09-17 13:12:17	3	5	49	0	0	76	0	32.80	64	2.89	CHANGED	-FI+psLoYDMPsEllYLVNulIESTKpllss.p	.EFIRRSLSYDMPPEVVYLVNAIIDSAKRlsES.I..	0	0	0	0
+12250	PF12416	DUF3668		Cep120 protein	Gavin OL, Bateman A	lg7	Bateman A	Family	This family includes the Cep120 protein which is associated with centriole structure and function [3].	21.80	21.80	22.20	22.40	20.90	19.40	hmmbuild  -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.11	0.70	-5.24	16	109	2009-09-17 12:13:09	2009-09-17 13:13:09	3	8	80	0	73	121	0	295.20	39	33.78	CHANGED	hlVlsIlEG+sFspc.......+pplllpAphs........ucsLpTD...............Plspt-sstFsocLsWE........hD+psl+..........+h+sp+sPlKLpCaAsc.tsst+EsIGYllLslRus....ptsp.p....ps+WapLLus...capphKPEl.hlhlslEscsh.t.ts.p..h........psppsPsppu.....ss.h..s.tplhshhhs-pGhhQlGsssh.ssDhallslpltpsppLspL.hs.s..l.t+..t.sshhhhYslLGNDVTsc.pFpp.hsssa.hpcs..lRl+SSlpsL+hahspp.stL.Iplpp....t.......ppulusoplshssLlstssh.th.....sp+hsshpGsFshp..stscs...............ss-.htPplslsloLchc	.............................................................hlVlpllE..G+pFspp.......cp.lllpApFsGEpLtTD.....PlpHs-pPpFsTELAWElD++sL+ppRhQRTPIKL......pCFAlc.....sho.st+EslGYllLDLRss....pps..p....ts+WapLLus...+.......Ys+aKsEl..lulslEs-sp....ssc.th................KuptsPPcpu...ps.s.....tlsspsl..hshLtp-tGaaQIGP..s-h..ssD.FlhSloluaAp.pLcpL.lsss....Lstc....spFaFhYs..LLGN.-VTs-.sFpsLhs....P......sFpsERsS.lRlRSSlcsL+hYLshp.stLpIaLCs....G...........spu.LGssclsLssLLtpssh.ph.......sp+sssh-GuFhlpsss+scp...............sh-..htPplslolsLph.p.....................................	0	29	34	53
+12251	PF12417	DUF3669		Zinc finger protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 64 and 80 amino acids in length.	21.60	21.60	22.30	21.90	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.22	0.72	-4.25	23	311	2009-09-17 12:13:48	2009-09-17 13:13:48	3	38	80	0	172	301	0	75.70	43	14.96	CHANGED	hWhlDFstsps......hphs.css.ltp......hlsAahcNDsaaPRPt.......t..stpLWssFcppYl.suptlhpshhh...hcs	.....................h-hshhsshss.h.slE+K.h-up.us+............LlsLEGRTGssEKKLA................-CEKTusEhuNplEuKWsVLGTLLQEYGLLQRRLEN..............	0	16	39	68
+12252	PF12418	AcylCoA_DH_N		Acyl-CoA dehydrogenase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF02770, Pfam:PF00441, Pfam:PF02771. This family is one of the enzymes involved in AcylCoA interaction in beta-oxidation.	21.20	21.20	21.20	21.30	21.00	21.10	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-7.23	0.72	-4.26	232	1684	2009-09-17 12:14:12	2009-09-17 13:14:12	3	9	805	0	589	1505	340	32.30	33	5.44	CHANGED	ssYpuslRDhpFlLpElhshcthh..shssas-hs	........pYpAPlRDhpFlLpElLshcthh..shstas-hs.................	0	150	332	482
+12253	PF12419	DUF3670		SNF2 Helicase protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00271, Pfam:PF00176. Most of the proteins in this family are annotated as SNF2 helicases but there is little accompanying literature to confirm this.	27.60	27.60	28.10	31.00	26.50	25.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.51	0.71	-4.74	105	583	2009-09-17 12:16:04	2009-09-17 13:16:04	3	5	516	0	181	587	58	139.80	27	14.45	CHANGED	L.psstPpshp..Lssp-shpFLppsu.tLpsuGlsVlLPsthpt.t...tp+lplclps............................sss.sst......uhlulcsLlsFcWclulGs....psLoppEhppLsppppsLVcl+GpWVplDspclppstchhpp.ttpt.........loht-sLchshs	.............................shp..Lssp-shpFLspsuspLpsuGlsVlLPshWppht...ts+hplclps..........................................ttsss.ssp........uhhGhss..LlsFcWclulGs.............tsLocpEhpcLs...c....pppsLlcl+GpWltlDsptlccspchhpc.ttp.t..........lsht-hLphth.t..................	0	61	131	163
+12254	PF12420	DUF3671		Protein of unknown function 	Gavin O	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 96 and 116 amino acids in length.	22.10	22.10	22.30	23.40	21.80	22.00	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.60	0.72	-4.05	42	76	2009-09-17 12:17:00	2009-09-17 13:17:00	3	2	4	0	39	97	1	108.20	37	46.74	CHANGED	KKcGL..................c+LDsYCEKKlFsplcplpclscshshcKKpaKphlhKKYG...hhlll.sLhs.llGlIlslLht.ht.th......................................h..hphhFhhlhsslhlLhllYlhhKllKY-	................KKcGLcKLDCYCE+KIFsslD+lcKhtcstNhDKKsaKpl.llKKYG...htlIhssLhs.LlGlIlsILsh.tpsth.......t...........................h.thlsslshsFah.assIhlLsllYIhhKllKY-........................................	0	0	0	34
+12255	PF12421	DUF3672		Fibronectin type III protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is typically between 126 and 146 amino acids in length. The family is found in association with Pfam:PF09327, Pfam:PF00041. There are two completely conserved G residues that may be functionally important. Many of the proteins in this family are annotated as fibronectin type III however there is little accompanying literature to confirm this.	23.60	23.60	23.90	23.70	22.80	23.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.65	0.71	-4.02	25	1261	2009-09-17 12:19:22	2009-09-17 13:19:22	3	19	403	0	22	1470	7	135.60	56	15.88	CHANGED	lspsGphphpNuslpG..............slsAsSGshsssshspssphtGslpAppIc.G.....Dll+..........hh.tt.................h.hpsh..ss.sasRplhl..........................ttt.p.....hhh.pshshtlppstthlhstssssh....hssh.......hshPs.sp	..............LTPDG+LTAKNADISG..............sVNANSGTLN.....NVT.....INENCplhGKLSANQIE.G.....DlVKTVuKuF...........ss........................pasSGTlTVpl.DDQ....sFDRQIlIP....................ustapstpppppps..shYSoC+L.VpKNGsEIaspsshDsp...hlaSuV.......IDMPAG.............................................................................................................................................................................................................................................	0	3	5	12
+12256	PF12422	Condensin2nSMC		Condensin II non structural maintenance of chromosomes subunit	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.	21.70	21.70	22.50	21.80	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.94	0.71	-4.47	26	201	2009-09-17 12:21:28	2009-09-17 13:21:28	3	7	99	0	119	184	1	148.20	29	21.30	CHANGED	Llpshhssthlps.-Gp+hluhlhs.hpt.hhcchtshl+spl...phs+uhlptau-lhapuWKpu...............ptshppplEpshlpshhpsulcs.....ts.hhusphRphLpsFtpp+.hpttV-phL..hclhcPlLaRuLpssNspV...RtNuhtlhhp.hFPlpss	......................hLtsFhssshlts.p..u.phlShLhs.hphshh+thpshlcs.l...tths+slhphhu.-lhacuWppu................tphhpplcpspIQDhh.tulcL...............cp..sas+sRcsLthFhppK..h..tlcchL...hcl.hcPlLa+uLpssNupV...Rssuthlhlc.AFPlcs....................	0	35	52	84
+12257	PF12423	KIF1B		Kinesin protein 1B	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00225, Pfam:PF00498. KIF1B is an anterograde motor for transport of mitochondria in axons of neuronal cells.	22.20	22.20	22.20	22.40	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.43	0.72	-3.93	42	516	2009-09-17 12:24:20	2009-09-17 13:24:20	3	40	167	0	305	465	1	46.90	37	3.03	CHANGED	hpNRlhtMR.-hYpph........................................hptt............pp...........h.ptpDPFa-s..-paslIGs	..........................LcpRL..MR.-hY.pch......................t............................pps.sst......................cp............hhptuDPFY-p..c.apLlGs...........	0	90	120	213
+12258	PF12424	ATP_Ca_trans_C		Plasma membrane calcium transporter ATPase C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00689, Pfam:PF00122, Pfam:PF00702, Pfam:PF00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.	22.90	22.90	23.70	23.10	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.28	0.72	-3.61	19	534	2009-09-17 12:25:56	2009-09-17 13:25:56	3	22	95	2	238	453	0	56.10	47	6.66	CHANGED	GQILWhRGLsRlQTQIRVV+AF+SsL..tcshcpspSpsu.l+shhs.sph..slpcphpp.shlsppc	................GQILWhRGLNRIQT.QI....+VVpAF+Suh....h.p.....u..l..c+..pS.hsS....lHshhst.ph...h.t............s..................................................	0	32	49	134
+12259	PF12425	DUF3673		Protein of unknown function (DUF3673) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length.	22.30	22.30	23.20	23.60	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.47	0.72	-4.12	19	52	2009-09-17 12:28:21	2009-09-17 13:28:21	3	4	3	0	29	47	0	51.70	42	28.82	CHANGED	Rhssc-hhssspthshl-sc+t.h.......pc-suHApssssaspcchs.h....sspsph.+ts	......hhsscDhhToscchuYlEccKGYs.......E-EsuHAQsssVYANKKhl.Y.....usKsphs+..h.........	0	0	0	3
+12260	PF12426	DUF3674		RNA dependent RNA polymerase	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 40 amino acids in length. There is a conserved MFNLKF sequence motif. There are two completely conserved residues (E and P) that may be functionally important.	22.00	22.00	22.80	47.90	19.90	21.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.02	0.72	-4.55	8	125	2009-09-17 12:29:39	2009-09-17 13:29:39	3	2	47	0	0	100	0	40.30	63	3.25	CHANGED	LIKs-ERuALEAMFNLKFHlus.KspsYhIP-Y+slp.spP	..........LIKsDERuALEAMFNLKFHloGsKsRsFsIPsY+PQsLCpP.......	0	0	0	0
+12261	PF12427	DUF3665		Branched-chain amino acid aminotransferase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 23 and 35 amino acids in length. The family is found in association with Pfam:PF01063. There is a conserved TRT sequence motif.	25.00	25.00	43.40	42.30	23.80	20.50	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.30	0.72	-6.73	0.72	-4.51	3	14	2009-09-17 12:33:33	2009-09-17 13:33:33	3	1	12	0	3	14	0	26.30	72	7.06	CHANGED	M............L-YTVTRT-sPTSP-RLKEILA	..............L-aTVTRTENPTSP-RLKEILA.	0	1	2	3
+12262	PF12428	DUF3675		Protein of unknown function (DUF3675) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF00097. There are two completely conserved residues (R and L) that may be functionally important.	21.10	21.10	21.10	21.10	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.46	0.71	-3.84	30	175	2009-09-18 09:02:28	2009-09-18 10:02:28	3	3	21	0	96	161	0	110.10	34	44.96	CHANGED	PGYTAPs.phsphscsslslp....usWp..ssth-.c-schlAhstuppphhpsth..s-hssssspuusaCRSlAllhMsLLLLRHsLslsh..sus-chuhsl.ho...LhhLRsAGILLPhYlhh+ulo	...............................PGYTAPP...hhp....schslslp............ssap....hsth-.c..cschlAhstuppphh.ps-a.s-hssssssuushCRSlAlI.......hMsLLLLRHslslsp...sss-c.shs...l..Fo...lhlLRsAGhLLPhYlhhhul.......................................	0	8	52	75
+12263	PF12429	DUF3676		Protein of unknown function (DUF3676) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 230 amino acids in length.	25.00	25.00	34.40	34.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.53	0.70	-4.75	27	92	2009-09-18 09:05:25	2009-09-18 10:05:25	3	8	2	0	40	93	0	193.10	63	27.25	CHANGED	TDsSVASES+SEESs.sSaEcLsEsDTDcQ.EEpsVcs.VPAAssSTVsAGSSVsEPAhAAESAtNS+sEDNAQLSEGcTuQQuT.sEspcSMQRDSDVQsQD.QSpELTEVsDVEtSSES.DsEpPEEEGcANDRSGGoTSsVuASLSM-TATusVsGEHQVQQSsELuAENcDVRSTGTGTTGAEpSLSLEAGDuNSERTMuSDSSLTPSKSDAEPTSAEsTDslSRTEG	..TcsSVASESpSEES..sSaEcLsEsDs-cQ.EEpsVcs.VPAAsSSTssuGSSVsEPAhAsESAtNSh.-DNAQhSpGETuQQsT.pEspcSMQRsS-VQsQD.QS...tc.TEhsDVEtSuES.Dpp.PEE-ttss-tSGtoTSsVuAS.sM-TsstsV.uEHQVQQSsEhusENsDVRSTGTGTTGAEpSLSLEAGDtNSERTMsSDSS.TPS+SDAEsTSAEsTDslShTEt..................	0	0	0	40
+12264	PF12430	ABA_GPCR		Abscisic acid G-protein coupled receptor 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 177 and 216 amino acids in length. This family is part of the abscisic acid (ABA) G-protein coupled receptor. ABA is a stress hormone in plants.	22.10	22.10	23.30	30.10	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.22	0.71	-5.17	44	301	2009-09-18 09:06:13	2009-09-18 10:06:13	3	10	234	0	216	311	1	172.90	36	36.74	CHANGED	p.ptthupThhG+hhphh.shhhulYCla+lhhshlphlhhh...............................ssssDslstslshhlp...........hhshpl...Dhp.hhspplShlLsGslhlsShpsllhohpp...hhphhsushs..ss.....................................hhsLlluplhGhYhlSolLLlRssLPt............ph.pshlsc............lLu............sslch.tFhcpWFDhlFllSulhohlhlhhtcphs	..............................t.thupThhG.+hhsh.h.GahFSlYClaKlhhshlsllhpp................................supsDPlopslplhlp....................ahs.hph.......Dlt.hhoppIShlLlGhlllsSlRulLhTlp+...hhhh.luushu..ss.....................................hllLlluplMG.hYFlSolLLlRhshP..........................-h.+shloc......................lLG..............plpa.sFac+WFDslFll.......Sulhollhlhltc+..s....................	0	82	125	181
+12265	PF12431	CitT		Transcriptional regulator 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00072.  There is a single completely conserved residue G that may be functionally important. CitT is a transcriptional regulator which allows transcription of the citM gene which codes for the secondary transporter in the Mg-citrate transport complex.	21.60	21.60	21.60	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.40	0.72	-3.80	48	854	2009-09-18 09:08:13	2009-09-18 10:08:13	3	6	644	0	81	293	7	29.40	49	13.06	CHANGED	lsQptVDphhptts....pspst..sp..LPKGIDpl	..AsQcplDcMFNshA......+s-sp...sc..LPpGIDt...	0	17	32	57
+12266	PF12432	DUF3677		Protein of unknown function (DUF3677) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length.	25.00	25.00	28.00	28.80	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.66	0.72	-3.54	19	104	2009-09-18 09:13:42	2009-09-18 10:13:42	3	3	83	0	79	115	0	81.20	45	4.34	CHANGED	l...L+hLstssGhtplRhhss.....p+lEhWlpNsKlp+.sp-L.LhhlhhNsss.......pstpDh-.slstLl+lth+sps...........lhshahtsl+cl	......lL+hLosoCGhtEVRhhul.....pRLEhWLpNPK..Ls..........R...sAQ-L.LhplChNCso.......+uscDh-.VlupLlKlRLKsKs..........LlNaahhCl+El.......................	0	29	37	60
+12267	PF12433	PV_NSP1		Parvovirus non-structural protein 1 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 109 and 668 amino acids in length. Parvoviral NSPs regulate host gene expression through histone acetylation.	25.00	25.00	67.70	67.00	22.30	19.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.73	0.72	-3.91	5	227	2009-09-18 09:15:31	2009-09-18 10:15:31	3	3	33	0	0	240	0	65.90	56	16.25	CHANGED	lLTYpHKQTKKDYsKsVHFGNMIAYYFLNKKKIsT-..+-cGYFLSoDSGahsNFLKppER+lVSKLYTDEpKPETVETTVT	.hpYhHKQTKpDYsK.VphtshlhhYhhNKcKIsc-..p.cGYahuusuGhh.................................	0	0	0	0
+12268	PF12434	Malate_DH		Malate dehydrogenase enzyme 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00390, Pfam:PF03949, Pfam:PF01515. There is a conserved AAL sequence motif.  There is a single completely conserved residue R that may be functionally important. Malate dehydrogenase is one of the enzymes involved in the citric acid cycle in mitochondria. It converts malate to oxaloacetate using NAD as a cofactor.	21.50	21.50	21.50	21.50	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.85	0.72	-7.06	0.72	-4.24	5	120	2009-09-18 09:25:20	2009-09-18 10:25:20	3	5	117	\N	46	104	24	22.60	67	2.97	CHANGED	s......osSc-DLK...-QQRAALRKAALEYHEFP	.............ss.................t+tpLRcAAL-YHEFP	0	3	20	33
+12269	PF12435	DUF3678		Protein of unknown function (DUF3678) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length.	20.40	20.40	22.10	21.80	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.70	0.72	-4.39	16	44	2009-09-18 09:28:31	2009-09-18 10:28:31	3	4	4	0	30	39	0	35.00	34	14.18	CHANGED	hhso-lhlpusus..........soSSushsHpppc+hFlchsol	.....hho-lhltAsus..........sooSsshhHpppc+hFlcasoh.	0	0	0	5
+12270	PF12436	USP7_ICP0_bdg	USP7;	ICP0-binding domain of Ubiquitin-specific protease 7	Gavin OL, Coggill P	lg7	Prosite	Family	This domain is one of two C-terminal domains on the much longer ubiquitin-specific proteases. This particular one is found to interact with the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110.	27.00	27.00	27.40	27.50	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.54	0.70	-5.14	52	419	2009-09-18 09:30:54	2009-09-18 10:30:54	3	25	258	2	276	415	4	231.30	28	22.05	CHANGED	phRhWhhsp.RpN..........+ThRP.......sp.l..p-.shTlpp..ltsp.ss.pt.th+lalElh.......................tt.....ss.pspp..slLlFlKhaDsppppLphlG+lalptspKls-..llPhlpchhua....sssTplpLaEEIK......sMh-.l...........c.ctohpp.....uElpDGDIIsFQ+shs......................t.psphthssshpaa-aLhNRl.VpFtsh...tpPpc.s...........sFsLpLSc+hoYDplupcVup+Lsh.DPp+LRFsssts.h....stpP+...h+...s...hspoLp-l..L	...................................................RhW.h.p.RpN..........tThRP..........sh....t-....s....oh..tp........hhp.....p...tp....................hplalEh..................................................................t.t.h..ss.s..ppp.....slllFlKh...a..Ds.p....p...p...p.LphsG+lal.ptss+.lp-..lhshlpchhGa.......sss..spl.LYEEl+.............................shh-.l...........c.c.ohpp.................sEltDGDIIsFQ+ssst.........................................psps...phssstpaachLhpRh.........Vh.Fpsh.p.spc.s.........................................................tFsltLSpphsYp..p..lscpVup....pLs.........h..DP.....hl..phhthts........pttPt...h+.......p....tpl.ph............................................................................	0	88	151	228
+12271	PF12437	GSIII_N		Glutamine synthetase type III N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. The family is found in association with Pfam:PF00120. This family is the N terminal region of glutamine synthetase type III which is one of the enzymes responsible for generation of glutamine through conversion glutamate to glutamine by the incorporation of ammonia (NH3).	25.00	25.00	31.10	30.80	19.30	18.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.83	0.71	-4.85	106	750	2009-09-18 09:35:47	2009-09-18 10:35:47	3	3	601	6	222	705	101	162.80	58	23.02	CHANGED	ppls-hFGppVFscpsM+cpLPKssY+pLpcoIcpGptL.DhplA-sVAsAMK-WAl-+GATHYT.HWFQPL....T..GhTAEKHDoFls.sss-.G....p.slhcFSGKpLlpGEPDASSFPsGGLRuTFEARGYTAWDsTSPAFIhcp...s...sLCIPTsFsSYoGEALDpKTPLLRS	...........p.hs-hFGppVFscpsMccpLPKplYKplpcsI-pG.ptL.DhplADsVAsuMK-WAlE+GATHYT.HWFQPL........T.GhTAEKHDuFls.sssc.G.......p.sltcFSGKpLlpGEPDASSFPsGGlRuTFEARGYTAWDsTSPAFlh-........sTLCIPTsFhSYTGEALDpKTPLLRS...............	0	108	185	212
+12272	PF12438	DUF3679		Protein of unknown function (DUF3679) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length.	20.90	20.90	21.30	23.10	19.80	20.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.61	0.72	-4.61	14	131	2009-09-18 09:40:58	2009-09-18 10:40:58	3	1	130	0	16	88	0	51.90	54	47.82	CHANGED	+sllhshlhhhGVLhGMQpANcGhppMKGYcDsohpsshplscscssphEAulLGp	...hh.hhlhhhMVlAGVuLANHGLKSMKGYpQhSYEQIAHMTGTcupssEoEILGp.......................	2	2	8	10
+12273	PF12439	GDE_N		Glycogen debranching enzyme N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is typically between 218 and 229 amino acids in length. The family is found in association with Pfam:PF06202. Glycogen debranching enzyme catalyses the debranching of amylopectin in glycogen. This is done by transferring three glucose subunits of glycogen from one parallel chain to another. This has the effect of enabling the glucose residues to become more accessible for glycolysis.	21.30	21.30	31.50	23.50	19.50	15.40	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.36	0.70	-5.11	94	351	2009-09-18 09:42:53	2009-09-18 10:42:53	3	6	336	0	118	343	25	219.70	31	32.83	CHANGED	+EWLlTNGlGGYAuuT.lsGs.TRpYHGLLlAulps..PhsR.hlllocL-Eplth.ssp...........pasLuspca..........sss.htspGap.aLppF.ph-.shPhWpaph....sssh.lcKclhM.pu..............................................................pNsshlpY..p......hhpu..sp......shpLplcPhlshRsaHshspss..h.........................thphpht.h.tp..s.............lplpshs..........thssltlh..hs.t.....u..ph.httss............WahshpYshEpc.RGhssp-DhasPGhhphsLps...Gpslhl.s	............+EaLhTNthGuYusuT.lsssNTR+YHGLLlsslss..sss.R.alLLSp.L-Eslh..pGt...........................pasLuhp.....+a..........tss.hpPpGa+..alpcF..ph-..tlPshhYcl.....usll.lcKclhh.pt..............................................................pNpl.hlc.Y.p.........lhsu......ps............sspLcl+PhlsaRsh+tho+ps.th...........................shph..s..ps..G..............lphshhs..........shspLhhp.....hsp.......s..ph..hptss...........WYpshpYstEp-.RGhshpEDLasPGhFchslpt.G-slhh.s................	0	48	89	109
+12274	PF12440	MAGE_N		Melanoma associated antigen family N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with Pfam:PF01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognised by cytotoxic T lymphocytes (CTLs).	21.90	21.90	22.00	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.18	0.72	-3.70	33	530	2009-09-18 09:45:57	2009-09-18 10:45:57	3	8	23	0	267	572	0	89.70	29	28.27	CHANGED	+uQKSptpstEcchQAptEspsL.ssQsssu-cp..tusuSs.sh..ss.ppssu.uGssssPQ.usQtAsossoshsu.s.........stspSsEuups.ptEE.ssuso	...............................tQ+SphpthEcp.hpup.....sEsp.......uL..suQs...sssccp..........pssS....S.......u...s...s.......hht..ss.......ppss..A.uss.ss.....PQ.u.PQtuss.ssoshss..s....................shs.pS.sEuupu..QpEc.ssss................................	0	24	24	36
+12275	PF12441	DUF3680		Protein of unknown function (DUF3680) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is approximately 40 amino acids in length.	27.70	27.70	28.20	28.90	26.70	27.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.80	0.72	-4.11	33	91	2009-09-18 09:47:12	2009-09-18 10:47:12	3	2	76	0	37	92	16	40.70	32	46.20	CHANGED	hp.KplP.cFco-tEtcpFW-pHDso-YhD......phpplpFs.h+.	..........ctlP.phco-pEtccFW-o..pDhT-Yhs.......phpslph............	0	7	24	32
+12276	PF12442	DUF3681		Protein of unknown function (DUF3681) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 212 amino acids in length. There is a single completely conserved residue G that may be functionally important.	24.30	24.30	24.50	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.59	0.72	-3.85	22	90	2009-09-18 09:49:35	2009-09-18 10:49:35	3	6	6	0	54	67	0	96.20	30	49.03	CHANGED	uspsh.ph.hALhshGlsTsusAhhshh.........hpsP..sGhhs.t.....hhYhlh...LsushlsGlstshsuhWVu.ssstt.....RRusG..+pllhsulsPLlh.s..........sh........uuhs.......l	..................s...s..th.tALhshGlsssuhAhslAh.......apsP..uGhht.h....hh...hYals...LsushlsGluplssu.h.WVu...sssts...........R+usG..+pllasulsPLlh.s.hulss...l...............................	0	0	10	27
+12277	PF12443	AKNA		AT-hook-containing transcription factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. This family contains a transcription factor which regulates the expression of the costimulatory molecules on lymphocytes.	26.20	26.20	26.60	32.90	25.80	26.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.37	0.72	-4.02	4	80	2009-09-18 09:52:05	2009-09-18 10:52:05	3	1	26	0	32	83	0	103.60	40	11.37	CHANGED	QpQIps..pl+ssptsLpu.E..puCpc.pPssQhssSpuoshhFphhpchct.h.+Ltpph-pLKs+lcphp+chc.susspLQDpp.shppL..psspLstP.Gss	................................ppQlph..pl+htpthLpt.E..puhpc.psspQhssSpuoshhFp.hpchct.h.+Ltpph-pLKs+lpphppc.c.sussph.....Dpp..sL.pLp.p.phL.ts.ht.s..................................	0	3	3	5
+12278	PF12444	Sox_N		Sox developmental protein N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 69 and 88 amino acids in length. The family is found in association with Pfam:PF00505. There are two conserved sequence motifs: YDW and PVR. This family contains Sox8, Sox9 and Sox10 proteins which have structural similarity. Sox proteins are involved in developmental processes.	22.30	22.30	22.80	24.80	21.60	22.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.27	0.72	-2.87	24	321	2009-09-18 09:55:34	2009-09-18 10:55:34	3	2	129	0	110	284	0	74.70	53	17.54	CHANGED	ssSPuhS--.sshSPs.s.usuGu....-o.......psst.tp........s.............................phcp-s-......D-+FPssIREAVSQVLcGYDWTLVPMPVRV	..........................................s..SPshS--.....pshSPs.s..Susuu........Do.................psststp..t......t.ts.............................chcp-s-.......--KFPlCIR-AVSQVLKGYDWTLVPMPVRV.....	0	14	22	59
+12279	PF12445	FliC		Flagellin protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 125 and 147 amino acids in length. The family is found in association with Pfam:PF00669, Pfam:PF00700. There are two completely conserved G residues that may be functionally important. This family is the flagellin motor protein which confers motility to bacterial cells.	21.90	21.90	21.90	22.50	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.99	0.71	-4.02	27	245	2009-09-18 09:56:18	2009-09-18 10:56:18	3	4	177	0	2	121	0	140.00	37	25.15	CHANGED	shpssuss......sussuoIThss....Gsohshsuu.........sss.......hsstssolSA-shtusspssu....aTs...ssus...tsassu..sssVshsu....................sssYscsDG.pLTTsss..s..sYahpsD.GsVTs....................ssGpslYhsADGclTT-Aso	......hh..tsuusuucsuolThs........GTpaohusus.........s..s............ssshsAoVSt-slhutsKusu.....sh.....ssuo.....hTa.ssGh.otslshsust..................sssYlDscG.slTsssshss..sY.lpcD.GoVTsst.................ssusGssVYVsusGKlTT-sTS...	0	0	1	1
+12280	PF12446	DUF3682		Protein of unknown function (DUF3682)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 125 and 136 amino acids in length.	25.00	25.00	97.10	97.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.07	0.71	-3.86	33	59	2009-09-18 10:02:37	2009-09-18 11:02:37	3	1	2	0	1	59	0	133.60	61	40.95	CHANGED	usGG..pGoG.GsuSuuuu.......ss...Puusssusussss..sAsuVDSSAGSSsGpAGSSGoNsSNTTGDSsTGDQos.AAAAApsSSPPEGPAGTTSGTGHTRQEEE......EEE-pEKQQQSDEsQVQ.QHQQHEHPAEsGE..ESA	................................................................................sspusGGsuuGuus.............sus..suusssus..u.sssss.......sAssVDoSAGSSsGpAGSSGoNsSNTTGDS.....sTGDQTs.AAAAApsSSPPEGPAGTTSGTGHTRQEEE......EEEEpEKQQQSDEsQVQ.QHQQHEHPAEsGEESA....	0	0	0	1
+12281	PF12447	DUF3683		Protein of unknown function (DUF3683)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF02754, Pfam:PF01565, Pfam:PF02913.	21.40	21.40	59.10	57.90	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.46	0.71	-4.26	42	271	2009-09-21 10:06:30	2009-09-21 11:06:30	3	6	267	0	96	256	43	122.00	63	9.53	CHANGED	.ssRlREIPYNYTSFSDREIVlRLLGp-sWphLs-LRsERpTGRSARMLaEVLGDIWVVpRNPYLpDDLL-sscRRptLl-AhpHRLspIccRps.............ssp+VtpLlsuA+pAVptFppp	...s.sRlREIPYNYTSFSDREIVIRLLG--AWplLs-LRucR+TGRSARMLaEVLGDIWVVpRNPYLpDDLL-NPKRRthLlcALpHRLsEIcKRRs...................csppVphLlsAAccAVccFspp.......	0	19	55	79
+12282	PF12448	Milton		Kinesin associated protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 143 and 173 amino acids in length. The family is found in association with Pfam:PF04849. This family is a region of the protein milton. Milton recruits the heavy chain of kinesin to mitochondria to allow the motor movement function of kinesin.	22.30	22.30	27.40	23.70	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.31	0.71	-4.05	16	296	2009-09-21 10:09:17	2009-09-21 11:09:17	3	7	65	0	163	225	0	164.70	29	31.66	CHANGED	sssptpsSsssssts..su....u..........u........h.hs...u..hhLpp+slSsts..sspS......st.tp.s...............................PuoPssp-LptAL+pLo.......h.......pRcNaLup+.hhshppEtphpthupt..tst.........P.....s-SlhSsss.....sth..............tphhLP-KLQ.IVKPhEuS	.....................................................................................................................p..........s...s..GSspo.Ss..o...............................hossc..S....ohphos..u...shlLpp+s..hSstlh.psts........tst.pp.us..............................P.uTPssschpsALppLo..........h.......tp-NaLu.p.....+..hhp...pEh+hpphs..................P......o-S..hh.Slus.................................t+hhLP-KLQ.IlKPhEu...............	0	13	27	87
+12283	PF12449	DUF3684		Protein of unknown function (DUF3684) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length.	19.50	19.50	32.70	23.20	18.50	17.90	hmmbuild  -o /dev/null HMM SEED	1093	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.96	0.70	-13.85	0.70	-6.98	22	109	2009-09-21 10:18:36	2009-09-21 11:18:36	3	7	94	0	90	113	0	917.70	39	61.55	CHANGED	LTFVu.LcsIElalDDasll+LpKKsuPshslsIP+clcT+TspGLM+lpslpppssQlDAshMphV..thpssust.h..tt.c..sss.......uoL+SFFS+housussp...cstpsppss..pttsptD...........ltphspuolFL+IsTAsIpsslupuhusELERATKKPPPKpoplAlLTsuYsph.AStts.................tspss..IFuulLPo+..uG..RlFIGFPTpQTTGlsuHlSAPSlIPTVERESIDLNsRalupWNhEhLRsAGllCRlAapsEMuslpscl..t.....t..ttuthccpcltsllscAlHshppFsF+-STPSotlGphIE-uFWoCs+sss.IElLSTpGVlsScpVRhsscsLS.FhcuIPVlPc-hhssApcFlp+Lp-hGLls-lTlsDIhpELcupsLspsQlh-FLpWl.......uccusuupl-.sshppLLssAVAs.ps.s.us.ss+llsLusIssalNPp+I.....Ps-LPlPPsllPapaoKsLspppLpul.GWpELpllsWLpaLlp...susscs.....-pDlTpSssFuspVLsVLSKpW-s.LusuoKpsVlshLpspTlIPTKhGM++PsEsYFsoV+LFDDLPlV.....pGlsulKEKhLsALGVRKTV-LslIF-RLLtssststt......ptcWSHVDLI+YLuSVcsDIPspDlcRL+pTslCsAE........ssppsptpRYKlS-LaEPc-uLRsLtLPllcW...PGcapssSsEu+FLhtLGL+saPss.-llclhu...tusDhpL+sKAhsYalspat.NsYusach..utsshsFLPl.p.....spp...pLusPppCFTscsAulhGFslLRp-L+s..HAsKhGVppHPshspClshLlppPPpocp-A+tlFpYlAuRlu-lsssc..lc+lupAtIVPV.pcphs.........pptpsh..phl......sPppCYL....Gcup-YpcIFDFVDFGtcANhFLhusGuKcEPTptElAphLl+EPARl.uthQSs-................+YLpLLRslA-shshL++c..+pLhpcM+pusFLLuS+-lspptpptst................pps-----psl+EWsLspApDhVlVDDhpSapLF+-plLu...APQEEhL.EsFYhsLGu.sLSuLVcEchchGs..hssDQc.AtcLcKlIhERo+LFLH	.....................................................LTFVu.LppIEhalDsapllpLpKKsuPshplslP..+slpo+Tt..pGlM+ltslpppssQlDAshMpsl.....tWps.sss..tt..ttt..s.t...................soL+o.FFS+housusts.................psts.p.t.t..p.t.tc-...............lhthpsuolFL+lsoAplpsplspuautELERATKKPPPKpTplulLTsS.....asph.uStss....................tpstclFuullPs+....uG..RlFIGFPTtQTTGhshHlSA.SlIPTVEREuIDLNsRalppWNhEhLRsuGIlsRlAassEMuslpsch..t.........t.tttst...hptctltthhscAlHhhppFsFpcSTPoutVuphlE-uFWsC.pp.ss.l-lhSopGll.sppVRlss...c-lo............FhcsIPVlPcphhsss..Flp+Lh-hGLlp-lTlsDlhpELcs+sLsppQhhpFlpWh.........sppuhssplc.sshppLLpsA.......V......As..........pp......................s....ss.....sspl...lsLuslpsalssp+I.....PsclPlPssslPhth..o+slsttpLpul...GW.p.tLplssWlpaLlp....sstsps.....-pslTpospFuhpVLsllSKpW-s.ls.ss.+psl....hshL.pshsslPTKhG........M++PsEuaFsoV+L..F-DLPsl.........puhpslKEKFLsALGVRKTV-LphIFpRLls...t..t...........ptcWSH..h-LI+YLsSVpsDIPspDhp+L+pothCsAE......................t......tstpsptphY+ss-LaEPp-slRsLt.L.PllpW...Pupaps.sS.Eu+FLh..LGL+paPss.pllphh........supc.....tL+spAhsYalspah.s.....tYssaph..ut.shshLPl.p.........sp.....t....tLssPppCFTs.tAslhGFtlL+p-Lps....HAsKFGVtpcPshttClshLl....tpP...............PpspppAthlFtYhusRlu-ls.sp..ht+ltpu.IlPl.ppt.s................ts.h...thl......sPppCYl.......GpuppYtsI..FDFV.DFGtpANhFLhtCGuKpEPTp.ElAthhsp-PsRl.shhpos-................+YLpLLRslA-shshl+..+s+tLhpcM+pusaLLus+-lssttpt...................tts.----tsl+papLspApchlllDDh.oapLF+-plls...APpE-hL.EshYhtLGu.tLSslVpEchph.Gs..hstcpp.AhpLp+hlhERo+LFLH..........	0	34	55	75
+12284	PF12450	vWF_A		von Willebrand factor 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00092. There are two conserved sequence motifs: STF and DVD.  There are two completely conserved residues (E and N) that may be functionally important. In hemostasis, platelet adhesion to the damaged vessel wall is mediated by several proteins, including von Willebrand factor. In solution vWF becomes immobilized via its A3 domain on the fibrillar collagen of the vessel wall and acts as an intermediary between collagen and the platelet receptor glycoprotein Ibalpha (GPIbalpha), which is the only platelet receptor that does not require prior activation for bond formation.	25.00	25.00	42.90	41.80	20.80	17.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.15	0.72	-4.29	102	412	2009-09-21 10:23:44	2009-09-21 11:23:44	3	14	391	0	114	363	52	102.50	46	17.29	CHANGED	ssshss.....spEpatphppNshhssuppPlSTFSlDVDTASYuslRRhLspG.pLP...PssAVRlEEhlNYFsYcY.stPs.........s.s.pPFulssEhussPW.NspppLl+	.................sstt.....s.sspcYpphs-Nsl+psup..sPLSTFSlDVDTuSYuNlRRaLN.p.G.pLP...PsDAVRlEEhlNYFsYDa.shPs..........s..s.tPFulphElussPW.NppppLl+.........	0	48	76	95
+12285	PF12451	VPS11_C		Vacuolar protein sorting protein 11 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. Vps 11 is one of the evolutionarily conserved class C vacuolar protein sorting genes (c-vps: vps11, vps16, vps18, and vps33), whose products physically associate to form the c-vps protein complex required for vesicle docking and fusion.	21.70	21.70	21.70	22.30	21.20	20.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.37	0.72	-4.10	39	245	2009-09-21 10:32:19	2009-09-21 11:32:19	3	9	213	0	176	248	0	49.00	36	5.09	CHANGED	ssc.pslcsl+csQpc.......stcpa-lFpptL...cpopDpFpllo-ahGRGlhpp	..........scscplhshh+sQcp.......st-pHDhFpppL...cpSpDpFullA-aFGRGVhs.......	0	48	91	145
+12286	PF12452	DUF3685		Protein of unknown function (DUF3685) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important.	25.00	25.00	47.00	27.40	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-10.89	0.71	-5.14	37	133	2009-09-21 10:33:30	2009-09-21 11:33:30	3	3	97	0	60	145	115	156.80	29	37.26	CHANGED	l.hsclPhs.pLhshLlhppsLhlDsthhssssscAhtphEhLLpNhlIplANslhp.lLNphuchppl.....+phlappphlSoR-lERhRNpLsWphRhppahpcPpsIaESpapLahlsspuIpph.lasPRppELppLsulthhVTLlLEhRDAlAPplcullthlGpslValLTpVlGRuIGLlGRGIlQGlG	........................................................................thllpshllphAshlht.hlp.hu...pl.....pp.hhp.ph....lSoRplp+hRNplshp.hhpphhppshtlaEsphpLhhlptt.t..Isph.l..sRppELppLphhph.lolhLEhpDshsP.lpshlphlGshhsahLspllGRulGLlh+GIhQuhG..........................	0	10	38	52
+12287	PF12453	PTP_N		Protein tyrosine phosphatase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00041. There is a single completely conserved residue L that may be functionally important. This family consists of various protein tyrosine phosphatase haematopoietic receptors, e.g. CD45, which dephosphorylate growth stimulating proteins. This limits growth signalling in haematopoietic cells.	21.90	21.90	21.90	22.50	20.20	19.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.56	0.72	-6.82	0.72	-4.23	7	91	2009-09-21 10:35:08	2009-09-21 11:35:08	3	16	27	0	5	93	0	27.30	48	5.26	CHANGED	LKLLAFGF.AFLDstsaVsGpussssssG	..LKLLAFGF.AhLDo-sFVTGpospsssos...	0	2	2	2
+12288	PF12454	Ecm33		GPI-anchored cell wall organization protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. Ecm33 is an essential cell wall component and is important for cell wall integrity.	23.20	23.20	23.40	23.40	22.60	22.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.26	0.72	-7.88	0.72	-4.08	18	53	2009-09-21 10:36:24	2009-09-21 11:36:24	3	3	53	0	38	48	0	40.10	45	10.10	CHANGED	MthlKYhLPA.LAAusushAs....sCu..tsTtTIpsQuDAsuLu	.........M.hhKYlLPA.LAsAGsAhAtt...sCs..tuohTIpsQuDAsuLu.	0	7	19	32
+12289	PF12455	Dynactin		Dynein associated protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with Pfam:PF01302. There is a single completely conserved residue E that may be functionally important. Dynactin has been associated with Dynein, a kinesin protein which is involved in organelle transport, mitotic spindle assembly and chromosome segregation. Dynactin anchors Dynein to specific subcellular structures.	25.00	25.00	25.40	27.20	21.30	24.70	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.61	0.70	-5.48	30	281	2009-09-21 10:37:31	2009-09-21 11:37:31	3	11	178	0	166	278	0	267.40	33	22.25	CHANGED	-L--hcsspp...pEs-ssphsspspshhslNhKLQsosuKApsKsIDlELp+hEuppuspHLpllphaLP-....ahc..u-+DulL.slLhhpRlutKusLlsstlpc+..........htpps.....hsupht-phh..hsscllppLshlsslsc+FhshlspCosEpFschsshh.EhpslE+tlDtaI-hLK+sclsEppssspLp+slshhscLtpsh.hs.....sph.shspphhtpsthhpstlDpsssshuhl+.shlpsthssssp............hhphhpslhspscusKhhspKlh...........Rpl	.....................................cLp-hppp.ps..ppptusch..ppp.s.tshshKlphutoKApsK.........sI-hELRphEstpAspHlslLpuF.hP-s...Fhc.........uGD+DslL.sLLLh.RlhtKAcLltppspE+.....................htcps......hpGsss.-phs......austllhpLshLpushc+atpulspCos-.hap+hushhsEhss..pERsLDhhI-LL++....DpLDEssss-.sLp+sItahpHLhpla.ls....pp.tsps..pltsphphhposLDshuspsupl+.shlQ.ss.....ppss-............................lhhhlcsL.spspsh+phspKlpRph............................................................	0	61	85	128
+12290	PF12456	hSac2		Inositol phosphatase 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with Pfam:PF02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.	21.80	21.80	22.10	22.50	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.30	0.71	-4.70	32	312	2009-09-21 10:38:54	2009-09-21 11:38:54	3	8	175	0	215	308	0	111.30	27	15.56	CHANGED	tst-....hphtphhppAl-ps.pphllsc.s....EchluuWhLh.....sscp.s.....s.p-plLLLTcpulalspaDats-+lspapRlsLsslppIphGhh.tsshp....sppcshshhlpaptss	..............h...c....hphtthhppslcsh.pp.hllss..s........-ph..hGuWhLh.....ps.ct.s..........s-p-plLLLTc..pulhlscYDhphc..Kl..spapRlsLpslppIphGt..a.hssht..........sc.pt.shplpap...s........................................	1	67	94	152
+12291	PF12457	TIP_N		Tuftelin interacting protein N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with Pfam:PF08697, Pfam:PF01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralisation of enamel - tuftelin.	22.20	22.20	23.60	23.60	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.66	0.72	-3.98	32	238	2009-09-21 10:39:50	2009-09-21 11:39:50	3	7	182	0	141	228	0	99.20	30	12.68	CHANGED	s-s-...-hE...cFEloDhDlcsE...........aNssRpRp..+poKcptlYGIaAppc-s-ppp.ttt.t...........ts++tpDYot.......PlsFVuGGlppsupc....cccpptppsp.....cpsccpst....ss	.....................p...-t...-h-pa-h.s-hDhpsE.............aNPpRpR+.....hpoK-pAhYG.laA-cssD-ptst.h...............ss++s+DYot.......PV...sFlSuGlppuupcctpppcppp...pppt.......................ttt....................................................	0	51	73	110
+12292	PF12458	DUF3686		ATPase involved in DNA repair 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 450 amino acids in length. There are two conserved sequence motifs: DVF and SPNGED.	25.00	25.00	118.90	39.80	18.10	17.70	hmmbuild  -o /dev/null HMM SEED	448	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.31	0.70	-6.22	31	104	2009-09-21 10:40:47	2009-09-21 11:40:47	3	5	101	0	36	112	9	438.60	47	26.48	CHANGED	cLpp+sppLNppRh-hFGus-hcLlGstRlRTENNClsRDIVpVG.................shlLFGYNVahGL+p-s.plsDVFSlach...........tpss.......sFcht.hshst....hLsDspFhpDFp-LY+YY+ss+LhpLthh.cs+LLAlFQlG-phpDlRVFRWplsscGt..pYlDsRGERDhshPspHDF-WpcsoR-s+VtG+HPHlSI..hDcVFVETlGGDLTIKlENNT-oGcGIYuEPV--.sQSLDDAclcYAclGsLILL+lhPYpEppaRYlVFNs+pppVhRlDuIGpAClpLP-DpGIIFPGGYYL.poG-hKsF-pshs..s....hcFcRslRSPNGEDVLYVFaptppGphlLhsYNlIc+plpsPlhCHGaulh-DGchllF+.up.-EPTRlHPhQlWQTPahS-pa.Aust..ssssuhLt+IGNs-LVRGlS-shulsphlpcp..ssosthYpsLhpsspclhDsYa	............LpppsppLNtpRh-.FGusphcllGp.RlRTENNClsRDIVpVG.................chLLFGYN.V...alG.L+.pEs.plsDVFoLY+h.....................t..spta-ht.hshsss...h.LsDssFlpDFs-LYpYY+ss+LlpLthp.-u+..LLAsFQlG-chsDlRVFRWplss.....DGp..pYlDsRGERDhshPst..aDF-WpcsTR-.pV.GRHPHlsI..h.DpVFVETlGGDLTIKlENNT-sGpGIYpEPVp-.sQSLDDAplcaAclGsLlLL+lhPY+EcpaRYLVFNohTppV.RlDuIGtuClpLPEDpGIIFPGGYYL.QsG-hKsF-...pshp......s....hcFcRplRSPNGEDVLYlFap.ppGchlLhsYNlIc+plpsPlhsHGaulh-DGchllFc.u.-....s.cEPoRlHPhQlWQTPFso-ca...AApp......ss...tsuhLsRIGNA-LVRGlS-hhsls+hlppp..ssotthYptLspsspclhDsYa.............................	0	12	25	33
+12293	PF12459	DUF3687		D-Ala-teichoic acid biosynthesis protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (L and Y) that may be functionally important.	25.00	25.00	30.80	29.90	22.20	22.10	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.71	0.72	-8.16	0.72	-4.72	33	811	2009-09-21 10:41:44	2009-09-21 11:41:44	3	2	808	0	47	183	0	43.50	43	89.74	CHANGED	h.....hhp+....ssspFlh+TlFYFhILlsLlYLYuYpGhspusFIYNE	................tpphhpFlh+TllYhhIhluLlalYua.pGpspusFIYNE....	0	8	19	30
+12294	PF12460	MMS19_C	MMS19_N;	RNAPII transcription regulator C-terminal	Gavin OL, Coggill P	lg7	Prosite	Domain	MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription [1]. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2]. This domain apparently shares homology with some HEAT repeat sequences.	27.00	27.00	27.00	27.20	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.33	0.70	-5.75	60	284	2012-10-11 20:01:02	2009-09-21 11:42:55	3	10	227	0	192	312	0	381.10	21	40.43	CHANGED	lsthl...stLscsssst.........................tphpphLcsLspluspppl.....hcslsh.pLls+lshhhp.......................ssphshslLpolhplhppptppp.....shshahpp.llshh.hphshsssspsps...........psLphluplhshllppLstpcppph.hp...plhshFh.........................h..ttt....tppphlhlhstlLuuLs+sssh......ptsp....LLpplhphshspss......thh+huhhchluhLlNK.hs...psp..........hpshLpphhpph........tt.tp.p.pslcllhWlsKALllRspstusphlsp..Lls......LLss.........pph...uptsAcuFplLls-...cslhst...............pptssl+lLaKQ+hFsplhPhl...hptacssss.................K.sY...LpALStlLp.slP..psllhscLspLLPLLLpoL........shsss...p...........lph..usLpTLtshlc-s..spllpc..alp..oLlspLLplu	.......................................................................................................................................h.phLphlstlshp.pl.....hp.h...hlhptl..h..........................................p.t.hhhhhtsl..hhpptt.t.........p.thhhpp.hh.hh.hthhhts...ttt.................................p.thLshhsplhshhsppls.phptp...hp..........ph.hslFh.....................................................h..t.t............t...ppphlhlhh.shl.suLs+ssphs........phtp.......................lhppllphs..hspss...............htphshhc......hhu.sLlNK.h.ssp..................thp.phlphhhpph..................................t.t..p.psh....pllhWlsKuLll....R.h..p..sh.ssplhsp..Lhp..............LLss.............................sph......u.tsAcuFslLhs-.....ss.lLsp...................................tstssl+lha+Q+hFsphhPhl.......lpthcssspt.......................................h+ssa...Lp.uLutlLp.plP....psl.lhs...clss.Ll...sL...LlpuL.........shsss.....s............................lph..usLpsLpsll.cs....sphhpt..alp....sLlsphLph......................................................	0	57	96	156
+12295	PF12461	DUF3688		Protein of unknown function (DUF3688) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is typically between 79 and 104 amino acids in length. There is a conserved YRW sequence motif. There is a single completely conserved residue Y that may be functionally important.	25.00	25.00	25.70	25.70	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.69	0.72	-3.60	38	86	2009-09-21 10:44:18	2009-09-21 11:44:18	3	2	6	0	0	86	0	91.90	31	26.06	CHANGED	DNKaYallh+spps.......ssWcIhK.FpNsppth........hh...tph............................................shhK.ulYRWsGssEP.phPs....ID.ssGpIpsW..........p	......................................................................................................................DNKaYhllh+ppps.......ssWpIhK.Fppsppt..h...........hh..t..t..h.......................................a...........shhKulYRWsGs.sEP...phPp.....ID.sTGpIpsW.....p.............	0	0	0	0
+12296	PF12462	Helicase_IV_N	Nucleolin_N;	DNA helicase IV / RNA helicase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 170 amino acids in length. This family is found in bacterial DNA helicase IV, at the N-terminus of Pfam:PF00580.	21.40	21.40	21.50	27.40	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.57	0.71	-4.60	36	672	2010-01-05 17:03:59	2009-09-21 11:51:44	3	8	665	0	62	352	3	164.40	57	24.00	CHANGED	McLpuoshuphlsQpsYpplcL.ssulploucp+phhIPFsplt.slps+RGllWGcLpFthss....ppslpl+GhpWp-sppFh............cplhpsappWspchschtsphLsphhppIpchpptspalscppltslhcplcpthpsLshslschtph.sspt...apphttWLpc	......MELKAToLGKRLA.QH.PYDRAhILNAGlKVSGDRHEYLIPFNQLL.AIHCKRGLVWGELEFVLP-....-KVVRLHGTEWuETQ+Fa.....................HaLDAHWpRWSsEMS-lAutVLppQlchIupRTGcN+WLTREpssGlpppIRQuhuALPLPV..sRLEEF-sCREh..WRKC.AWLpD..........................	0	4	19	40
+12297	PF12463	DUF3689		Protein of unknown function (DUF3689) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 399 and 797 amino acids in length.	21.70	21.70	33.90	33.40	18.70	21.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.78	0.70	-5.64	8	115	2009-09-21 10:58:33	2009-09-21 11:58:33	3	4	60	0	63	117	1	265.30	55	34.69	CHANGED	Vps.ltchtLl.sLsphF-pL.Whhptsp...hth.s.sssCosc.uLKIQFLRLlpsFsD+cpsp............tt.p..h.h..s.t..ss..s+shttcuppGLls+lLpshtp-st-ShaRFWlApuVEuFLRGssshtDQhalhpRGLlEHlLppIlcusscspcsLQhpFDLLGELhKFNpssFcRhsphlss-.KFph..FlctlsosLVDSNhFlRsVlLSL-pFcppts-hs..................tpshpcs+hlhhhp............spNph+hLpcLIshIplpslsQ-NlsCLNTuLlILhhAc+sGcL.hYLpuLRpt-hp	.......................................VH+MlAEF+LIPGLNNLFDKLIW...RKposS.s.hV.lH.uHNpNCDCSP-loLKIQFLRLLpSFSDHH-s+hlLhs........................................phsphSAlshc..sslPElcullNo......cRoLV..CDGK+GLLTRLLpVMK.+EPs-SSF....R..FWQARAVESFLRGsTSY..ADQhFLLKRGLL.......EHILaCIl....DScC.+.SRDVLQSYFDLLGELMKFN........lDAFKRFNKYlN.......T-.tKFQl...........FL.........pQINSSLVDSNMLVRClsLSLDRFEsQs.DhK......................................VscVL....SEC+LLuYhu.................ps.sphoFLFRLINIIpVQTLTQENVSCLNTSLVILMLARR+t+LPhYLphLpchEh.s...........................................	0	26	33	45
+12298	PF12464	Mac		Maltose acetyltransferase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00132. Mac uses acetyl-CoA as acetyl donor to acetylated cytoplasmic maltose.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.54	0.72	-3.95	351	3057	2009-09-21 11:01:47	2009-09-21 12:01:47	3	32	2089	58	602	2037	48	54.50	30	25.99	CHANGED	cEKMluGcl..........Yps.t..........Ds...E.LhptRtcu+clhtca.N.........ps...p...p............p.tp........cRpplL+cLhGpsGc	..................hEKMlAGch..........Yps.t..........Dt...p.LhpcRh+A+plhtcaN...............ps...t..sp................-.tp............cRppllccLhGpss................................	0	166	343	483
+12299	PF12465	Pr_beta_C		Proteasome beta subunits C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00227. There is a conserved GTT sequence motif. There is a single completely conserved residue Y that may be functionally important. This family includes the C terminal of the beta-type subunits of the proteasome, a multimeric complex that degrades proteins into peptides as part of the MHC class I-mediated Ag-presenting pathway.	20.30	20.30	21.40	21.30	20.00	20.10	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-7.70	0.72	-4.69	63	391	2009-09-21 11:37:50	2009-09-21 12:37:50	3	3	243	90	207	367	0	37.50	38	13.88	CHANGED	sNc+up+ptsY+atpGTTuVLscpl..hpl-lscp.pVps	..............sNp+sp+..ptpY+atpGTTAVLscpl..hpl-.lh-E.pVp.................	0	55	93	153
+12300	PF12466	GDH_N		Glutamate dehydrogenase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF05088.  There is a conserved ALR sequence motif. Glutamate dehydrogenase (GDH) is a homohexameric, mitochondrial enzyme that reversibly catalyses the oxidative deamination of L-glutamate to 2-oxoglutarate using either NADP(H) or NAD(H) with comparable efficacy.	25.00	25.00	25.80	38.20	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.85	0.72	-3.98	4	31	2009-09-21 11:39:53	2009-09-21 12:39:53	3	1	30	0	6	34	2	55.10	60	3.31	CHANGED	MpupKuASpSspsssKPsAEpuVsssAp..ptloLEPVFAALRKRYPAAtQuEVQtFAAD	.....MsuKKuhSpSspsssKssAcpulsshAp..puVoLEPVFAALRKRYPAAtQuEVQtFAAD.	0	1	3	4
+12301	PF12467	CMV_1a		Cucumber mosaic virus 1a protein family	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is typically between 156 and 171 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01660. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein.	25.00	25.00	43.70	42.60	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.12	0.71	-3.90	14	89	2009-09-21 12:27:24	2009-09-21 13:27:24	3	3	22	0	0	90	0	156.90	59	16.17	CHANGED	Whusho+sh..RsFlpshlpohFPoLR....+DcpEFLsKLSshsoF.NEpspsDhucphDVhusAAsl.......sshsVpsuKphts-KcKpht.stppPV.p.s.t.............s.ssc.sPtsssssps...spssp.pslospTcss-oRlApRusAMhEYssYpppLHsNsVSNL	.......WFAuhTRPl..RVFFSoV.V+sLFPTLR...PREEKEFLlKLSTFVTF.NEECSFDGGEEWDVISSAAaV.......AsQAVsDGKlLAupKAcKLA-+LApPV.ElSsp...............s.ssSsTPcDsussCG.cEpEsSELDSLSuQTRSPITRlAERATAMLEYuAYEKQLHDTTVSNL	0	0	0	0
+12302	PF12468	TTSSLRR		Type III secretion system leucine rich repeat protein  	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. There are two completely conserved residues (Y and W) that may be functionally important. This family consists of leucine-rich repeat proteins involved in type III secretion.	21.20	21.20	23.00	21.80	20.30	19.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.31	0.72	-4.42	25	427	2009-09-21 12:29:20	2009-09-21 13:29:20	3	37	178	4	17	313	0	45.10	35	7.66	CHANGED	shuhsssSh.st.......tssposs-YculWscWc+sAsss..EpRspAVp	...................t..psS...t......sssspssssYhslWs-Wc+pAsst..EpRppAVp......	0	0	7	9
+12303	PF12469	DUF3692		CRISPR-associated protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is typically between 101 and 138 amino acids in length. The proteins in this family are frequently annotated as CRISPR-associated proteins however there is little accompanying literature to confirm this.	21.90	21.90	22.80	23.10	20.50	21.40	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.54	0.71	-3.87	86	200	2009-09-21 12:31:19	2009-09-21 13:31:19	3	1	170	3	93	221	4	122.50	24	16.65	CHANGED	hllsloluPVQsFIspuR+s+DLWuGSalLShLstpshptl..hcp.............sst....llhP......t................t.................................................httsl.P.....................Nphhhhlsstt................hpthtcp......................scpshpctac..plscpl	.....llhholuPVQsFIspuR+s+DLWuGSalLShLsttshptl..hcp.t...........sss......llaP.......s.hptp........h...hhpphtt......................................................tsuh.P.....................................N+hhhh..lsssp................hpthtpp...................scpthpptapplhp..h......................................................................................................................................................	0	56	74	85
+12304	PF12470	SUFU_C		Suppressor of Fused Gli/Ci N terminal binding domain	Gavin OL	lg7	Manual	Family	This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with Pfam:PF05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologues. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologues.	25.00	25.00	32.70	28.80	23.70	22.40	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.18	0.71	-4.72	6	111	2009-09-21 13:09:09	2009-09-21 14:09:09	3	6	78	4	67	106	0	191.20	52	43.07	CHANGED	hcpl-cslE+-GSsLuGVsAchsacELs+ss.scp.sc.............cpsT-p.ppshpcshphppcus.sss.uppssshpps.............sshshspphsRspsLsGlcLphu.puAphLsLAlRsRlRHGRHFTF..pspchAlTFVopuVsGuhsoc-cPYushGsWlQILIss-hV.+Ml--hpDLooscs..LKlPhpYcWP-+sLKlhl	................................................................E+V-cGIEp-GSNLSGVSAKCsW--LocssEcc--ocshslup..........................................tp-TE.QIREsLp+GLchsscPlhP.slss.p+pNuhp+s........................ppsssshlPpELlR...TRpL-uVHLKFNtEuGuLlPLs..lRGRLhHGRHFTa.KS.IsGDhAITFVSoGVEGAFATEEHPYAA+GPWLQlLls-EhVp+MhcD....hp.sLsss-c.......hphPhpapWP-+pLpl.l.................................	0	20	24	45
+12305	PF12471	GTP_CH_N		GTP cyclohydrolase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. This family is the N terminal of GTP cyclohydrolase, the rate limiting enzyme in the synthesis of tetrahydrobiopterin.	25.00	25.00	50.80	35.80	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.23	0.71	-4.70	39	190	2009-09-21 15:39:55	2009-09-21 16:39:55	3	7	177	0	131	193	27	187.10	54	40.49	CHANGED	hss+IhLToaPsptshsPlPlpWGA.ssstcRGPVlso..hsshs+RNAIGsHuGSYulY+ALAVAuGpLsscH+sDhTNTpPshsIsPpPpWuDPpKIVShDPaGHlssphFschh.ppGhDIRPTIAlT+AHlplsElp-AlppGRLtsDGcllhs.................sG-ltVTKsAlEPVWYLPGVAcRFGlsEstLRRsLFEc	................h.s+IlLToaPsp.t..uhs.PlslcWGu.ssstpRGPVlso..ssshp+RNAIG...............uHuGSYSlYpALAVAuGtLss-HRPDhTNTpPsssIGPaPpWuDspKIVShDPWGHhlsphFtc.l..ppGl..DIRPTIAlT+A...HhpLPElp-AlppGR.....LhsDG+llls.....................................sG-lsVTKsAVEPVWYLPGVA-RFGlsEusLRRsLFEp.....	0	40	75	109
+12306	PF12472	DUF3693		Phage related protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is approximately 60 amino acids in length.	21.00	21.00	21.10	21.20	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.72	0.72	-4.37	31	83	2009-09-21 15:41:09	2009-09-21 16:41:09	3	4	62	0	13	83	0	55.90	28	40.57	CHANGED	lltl+u-+uco.pt+shWpsIhK+hsuhuhs......sluhs.hsuhuhuhststpslspssls	......LlslcA-+ucsspt+shWpsIsKKhsuhuhs......sluhs..hsuhuhshstsppslhpssl....................	0	3	7	9
+12307	PF12473	DUF3694		Kinesin protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 131 and 151 amino acids in length. The family is found in association with Pfam:PF00225, Pfam:PF00498. There is a single completely conserved residue W that may be functionally important.	21.80	21.80	21.90	22.20	20.60	21.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.76	0.71	-4.52	38	863	2009-09-21 15:44:23	2009-09-21 16:44:23	3	52	182	0	460	731	1	128.10	25	11.09	CHANGED	pYhPV.h.pssp...s.GsFpL+QGlp+Rlslslsppsupph....hpchhtlhluth+.h..ss..h........s..h.Lpl.lspt.......ss......................................shshhupWDSShH.sShhLNRhT.sppp+lhlTlshslhhsc.hscPlhFph-lslpIh.uRsth	.............................................................pahPs.h.pttt.....s.shF.L+Q...G.h.p++lslpl.pp.ps.s.ph................hcch.h.tlhl.....u.hp...........................s....h..htlhstp.................ps.........................................................................................................................................hphpusWDouhH.sp.hLNc.T..s..................s..c+l.ahtlts.l.............lpp.s.........hhhphchsh.hhsppt.t..............................................	0	114	158	301
+12308	PF12474	PKK		Polo kinase kinase 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF00069. Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosphorylates Polo kinase and Polo-like kinase to activate them. PKK is a serine/threonine kinase.	25.00	25.00	27.80	25.70	24.40	24.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.08	0.71	-4.46	23	413	2009-09-21 15:49:36	2009-09-21 16:49:36	3	10	84	0	193	333	0	135.60	35	24.19	CHANGED	+aplt+cQh+cpFh.p+ppLh++a-p.ElEplpRhppcplEchcpcQptE++chsKplRsEpcpchthF+-SL+lptp...pscp-hE+l...cpQc+cchKtc+pchppKHppp.c-hhuppcsslcp.Lpplpsc+++tLh..EpE	.........KcQht+pQl+cpa..pppphh+pa-p.EhEphpRhppphlEcLcpcQsp-++c.sKphR....uEtcpchuhF+csL+hppp.....psp...........p-h-+.l....p.pQcccp.K..p.c+.p.ppK+p.p.p.+-hhtppcps....lct............Lpplps...c+p+.Ls-pE.................	0	43	63	120
+12309	PF12475	Amdo_NSP		Amdovirus non-structural protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 50 amino acids in length. This family contains proteins of each of the four types of Amdovirus non-structural protein.	25.00	25.00	40.50	39.70	19.40	17.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.36	0.72	-4.06	7	138	2009-09-21 15:51:29	2009-09-21 16:51:29	3	3	3	0	0	147	0	46.60	63	33.50	CHANGED	YhDKspcPpcsp.sL....+phspDLtlhaoshcCshps.p-scscsp	.FDKNEDPKDVpKSLGWhlK+LN+DLA.lIaSNHHCD.QsIKDPEs+Ac......	0	0	0	0
+12310	PF12476	DUF3696		Protein of unknown function (DUF3696)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length.	21.70	21.70	22.60	21.70	21.60	20.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.55	0.72	-3.99	58	201	2009-09-21 15:55:04	2009-09-21 16:55:04	3	4	191	0	67	169	38	49.90	25	12.02	CHANGED	lsscclulaah.....ppspttsplpplp.lscpGcl..spWP.....cGFFDphttph.pLh	............................ppltlhah.....ppssssoplpplp.lsppGpl..spWP.....cGFFDpt.h-h..h.............	0	26	46	57
+12311	PF12477	TraW_N		Sex factor F TraW protein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. The traW gene of the E. coli K-12 sex factor, F, encodes one of the numerous proteins required for conjugative transfer of this plasmid.	21.30	21.30	21.80	21.30	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.03	0.72	-3.91	21	169	2009-09-21 15:57:01	2009-09-21 16:57:01	3	1	137	0	29	121	8	30.20	55	14.12	CHANGED	hhhhhlhshlhhussApApsLGshGssaPIu	......hpspuLlALLlaGQS.VsAADLGTWGDLWPV.p.	0	5	12	24
+12312	PF12478	DUF3697		Ubiquitin-associated protein 2 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF00627. There are two conserved sequence motifs: AVEMPG and QFG.	22.20	22.20	23.10	23.00	21.50	19.70	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.01	0.72	-7.51	0.72	-4.31	7	185	2009-09-21 15:58:24	2009-09-21 16:58:24	3	3	70	0	80	193	0	33.20	77	3.25	CHANGED	.sopIPuoAVEMPGuu..slsuLslQFGAL-FGSE	..PsSKIPAoAVEMPGSA.....DloGLNlQFGAL-FGSE......	0	15	21	45
+12313	PF12479	DUF3698		Protein of unknown function (DUF3698) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 89 and 105 amino acids in length.	25.00	25.00	34.50	34.40	24.70	22.30	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.48	0.72	-3.95	11	45	2009-09-21 15:59:39	2009-09-21 16:59:39	3	3	1	\N	45	47	0	98.90	31	34.17	CHANGED	TltsGITLRSA.IAGFFYpsEs-uh-Tppphtpsasl.upKT.....ppsDPhhNVhP+shcps.....sh+..p.t........s.hhsltEsssp-.aps.....IcssTas	............hlcssls.h+sh.hsshhahspscu.soppp.thsFuI.shKTt.h.hppu...hplt.cs.ppp..phpphR.opp.s...............hushlhht.shpp..apA......Rs.h............	0	0	45	45
+12314	PF12480	DUF3699		Protein of unknown function (DUF3699) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length.	20.40	20.40	21.20	21.70	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.27	0.72	-4.34	17	310	2009-09-21 16:01:11	2009-09-21 17:01:11	3	9	30	0	145	276	1	75.50	33	13.82	CHANGED	tss.slpLophlPLph..VclplHstpphpLcl+hsouRsaYLpLsssscp.-slFstWl+Llp...lLp.shpthspsspl	...................t..s.plpLo...RhLPL+F..VcLplaDpppppL+l+hsT......sRsaYLp.Lsssscp.-slFshWh+Ll....lLp.shsthsps.t............	0	10	12	26
+12315	PF12481	DUF3700		Aluminium induced protein 	Gavin OL	lg7	Prosite	Domain	This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: YGL and LRDR. This family is related to GATase enzyme domains.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.46	0.70	-5.15	33	220	2012-10-03 21:14:07	2009-09-21 17:03:10	3	4	52	0	86	1785	730	191.40	46	86.72	CHANGED	LAlFcKulAcsP-ELpS.Psss.s.usth............................c...............ssptllpcFhSspP.suholshGs..uuhlAYotspps.....slhPRLFush.DDIaClF.GpL-NLssL+pQYGL.uKssNEshlVIEAYRTLRDRGPYPADQVV+-LpGpFAFVlaD.spssolFsAsDsDGpVPLaWGlsADGslVhSDDh-llKtuCGKSaAPFPp.GChFoSs.GGLpSFEHPhN+lKu...........hP......RlDSE...G.hC..........GAsFKV	.......................................................................................................LulFpttlspsPptL.u.st.t.........p.sttlhppFhstts..suhohphGs...uhhA..a...ot....tpps.......hp..R.Fush.D.-.Ia.C.l.F.GtL-NL....u....t....L.......p....p.....Q......Y....G.....L....u...K....s...s..N.....E....sh....h.VI.E.A.Y.+T..L.R...DR.u...P.....Y..P..A...sp.......V....lpcL...pG..pFAFVl.aDsp.......s.....p..olF.sA.t................sss.G.p....VsLa..WG.l..s............u.......D..G...p...l.shS..D....-.h....-...l..l.......K.....t.....u...C.u.K..S.hAP....F.Pp.G.Ch.apot.....uG.....L.......p...S...a.Ep..Ph..N+.l.pshPth-pc..hCGusFKV............................................................	0	12	61	73
+12316	PF12482	DUF3701		Phage integrase protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00589.	21.50	21.50	21.60	28.90	21.20	20.70	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.28	0.72	-4.24	38	151	2009-09-21 16:05:01	2009-09-21 17:05:01	3	5	74	0	61	147	10	96.20	37	16.67	CHANGED	ptLcshs....sssPthsDslstWLssplstsLputGIp.......TLu-LssRlsRRt.+WWpulPGLGssuARpIEAFhAsHsslst+u.....................psllhhs.pusllP...h	.........t..LcphssssPthsDsVshWLs..spss..tsLpAtGIp.......TLu-LssRlsRRt.pWWpulsGLGsuuARpIEAFhusHsshst+s..............puhlsh..ps.lsP.................................	0	3	11	45
+12317	PF12483	GIDE		E3 Ubiquitin ligase	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.	21.20	21.20	21.30	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.87	0.71	-4.87	31	280	2009-09-21 16:07:55	2009-09-21 17:07:55	3	6	190	0	162	283	43	144.10	22	45.07	CHANGED	ppphtccppp......hhpppochlspspcpsPFhLcD....s...........o.GcVhV..s.suutlshhhshcp.F....cs.ss.stsshthuhh..th.....................slGh+hhEclLPsspplhVlGps.pDstG..lpIppPppt.....FhlS.coc-pLhpphtpts+hhhhuulsh.......sllG	..............................................t....thhppppchlp.ptsp.psP.Fh...L...p..D...s.................s..stVhV..s..s.u.ss.l..s..l..p..sshcp.a......c.sst..shss.hh.hs.hhsutp.....................................hG..h..p.psEchL.sGssloslG-h..................h....tc.......s.....st....lp......l.p...sppt...........ah......l..o...s.pplhtp.tt.hphh.hhhshhh..h.......shhh.................................................................	0	44	89	131
+12318	PF12484	PE_PPE_C		Polymorphic PE/PPE proteins C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF00823.  There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this family are PE/PPE proteins implicated in immunostimulation and virulence.	21.80	21.80	22.10	22.10	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.16	0.72	-3.05	86	1529	2009-09-21 16:10:05	2009-09-21 17:10:05	3	5	63	0	165	799	0	84.80	32	22.29	CHANGED	V.uAu.l...GpAusl.GsLSVPsoWusu.....sPsssssus..........Lsssshssssssss.......sssh...h..GhP.........hsuhuutttsu..hs...........sRYGh........Rss..VMs.R....PP	.....VuAul.Gp.Au.sV.G.sLS.VPsuWusu........sP.u....s.sssuss.........lsssshsussssus.........ssh....hs..GhP.....huuhuu..t.usuu..su..................RhGh.....+.hVhs.+...........................................................	1	35	69	134
+12319	PF12485	SLY		Lymphocyte signaling adaptor protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with Pfam:PF07647, Pfam:PF07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.	25.00	25.00	59.20	59.20	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.16	0.71	-3.98	14	178	2009-09-22 08:22:33	2009-09-22 09:22:33	3	9	39	0	84	140	0	148.20	42	25.16	CHANGED	c.p.pRSoSFGcFct.+..sSPlps-cchsscpt......tttsscsssp...SuhsLGKK.h+u.IShTM++KMGKch.KAlSEEhs-ss-tcshssssss...t...h-Kssl+uusShESLaS.hSGQSSoSu.sVsSsSsGsSNRDSl+LE....-psP..YsGPF	......................................phtRS.oSFGsFDtp+.spS..ssps-cphpsc-s..h......htts.csssp...Su.tuLGKK.h+u.IScTM+KKMuKKY.K.uLSE-ht...-sst.tsuhssss.ssst.-s.ph-KssLKuusShESLhsshSGQSSoSu.sloSsssGo..SNR-..Sh+.E....--sP..YsGPF................	0	3	10	33
+12320	PF12486	DUF3702		ImpA domain protein 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 207 and 469 amino acids in length. The family is found in association with Pfam:PF06812.	25.80	25.80	31.70	31.50	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.86	0.71	-4.53	26	515	2009-09-22 08:23:51	2009-09-22 09:23:51	3	2	347	0	39	278	0	138.20	40	33.88	CHANGED	hppQLspLpplsPhaslphGppllcpApplWPss.phpthsppWppplpspAhsssplsuWpputspLppLu-+Lsth-cp+Gp.hTlS.LKoslashppsh.spshPlEEhLRQLptp.tpspsss.uhhppl-p+LptLLsRYhhLpp	...............pppLpQLhchsPl.sLcpGhphh+.AcshWP-s.Q.pphsspWpctlcspAtsss.pLpGWhQsppcLcthA-hl.phEcct...lTlS.lKoslaphcpuL.spE.sP.lEpLLpQhp-s.+s.pppsss.sLpKQIspRLptlLuRahlLpp.......................	0	0	10	19
+12321	PF12487	DUF3703		Protein of unknown function (DUF3703) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length.	21.10	21.10	21.70	21.20	20.70	20.10	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.49	0.71	-4.40	51	103	2009-09-22 08:25:31	2009-09-22 09:25:31	3	5	84	0	62	114	13	106.70	36	81.37	CHANGED	hsppl+thaptEhptAcps.ttushstsWpHLERAHIluQ.hshhHstsHhtMLthuh+p+DtREshGQllRllsussGShhG+hPhGNTGtusVushpPMPlPpDLtsllp	...............ppl+thaptEhptupps.ttsshptuapaLERAHIluQthshh...Hs....psHhtMLphuh+p+Dt+EshGQlhRllsus..stohhGhlPhGNTGtusVushpPMPlPp-Lttll.s......	0	17	34	50
+12322	PF12488	DUF3704		Protein of unknown function (DUF3704) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length.	21.90	21.90	22.80	22.30	19.50	17.70	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.66	0.72	-6.78	0.72	-4.32	8	22	2009-09-22 08:30:11	2009-09-22 09:30:11	3	2	7	0	16	27	0	27.10	65	20.88	CHANGED	hL.VG.......ASaGYMP+ssIAGSSsSshSNF	..hLPVG.......sSSGYMPRRGIAGSSuSoMSNF..	0	0	1	16
+12323	PF12489	ARA70		Nuclear coactivator	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.	22.10	22.10	23.50	30.80	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.96	0.71	-4.19	17	169	2009-09-22 08:56:56	2009-09-22 09:56:56	3	2	39	1	59	142	0	127.10	39	44.89	CHANGED	spspLp-.hhts+sthtsp..t.h.s.pshpsWL.....lhpphpppohp.pttph....pphhGphpsL.p.L.p................spops.ssphShphp+lusLsLpspEs................ochLhpssshphhpphsshG.hpspppch+.hh	.............................t.plp-.LhtsKst.tsp..t.h.s.pshps....WL......h.hQh.pEp...o......pu..pph.......lhGphpsLpp.L.p................sps+shssphSlphE+lusLpLhspDp................oshLhpsspsthhpp.sshu..cshp...+hh..............................	0	3	7	21
+12324	PF12490	BCAS3		Breast carcinoma amplified sequence 3 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 229 and 245 amino acids in length. The proteins in this family have been shown to be proto-oncogenes implicated in the development of breast cancer.	21.70	21.70	21.80	22.40	19.00	20.40	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.68	0.70	-5.07	19	188	2009-09-22 09:23:55	2009-09-22 10:23:55	3	6	103	0	117	200	0	227.20	26	26.76	CHANGED	PsPloLoVVSRIKsus.sGW..........tsoVs...sAAuoA.oG.+sshhuGAlAusFH.....ss..hstsspsssst.sssh-pLhVasPoGpll.QYhLcPusus....pss.t.shsptsthpp.......s-l+lhVEslppWslsR+ssh.Ep--.phsshstsspts..h..hhtssssct..............p.tts.pt........phpscEppchalSpAE.lphapsp.hPlWtcschpFpsh.ssps.p.p....ts.hu........sEhEI..EclsscplEhRpK-LlP	...........................................................................hsl.slupIKps..hGh..........................................h...p.........phusu...t..oh.t.hsluushusshp.........ss....hppptsppp..p.hsl-pLhlhos.GsLl.pahLcPpshs................ssp..hs--..............................oslclhspPhtpWslsRp.ph..-hps....shstsp.hhh.t............th.......................s.....thssht....................................sscstpccc..WLSplE.lhTHsGP...t+.LWhsPQ.......FpF+shp.sss.psh.....sss.u......................................................................	0	36	62	91
+12325	PF12491	ApoB100_C		Apolipoprotein B100 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. There are two conserved sequence motifs: QLS and LIDL. ApoB100 has an essential role in the assembly and secretion of triglyceride-rich lipoproteins and lipids transport.	21.20	21.20	21.20	38.90	21.00	18.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.76	0.72	-4.33	4	81	2009-09-22 09:27:57	2009-09-22 10:27:57	3	4	63	0	21	76	0	44.40	75	2.02	CHANGED	Qh+hKLQDFSDQLSDYYEKFIAEocRLIDLSIQpYHhFL+YIhELLKcLQssTssshh	..QFRYKLQDF.DQLSDYYEKFIsESKR....................................	0	1	2	7
+12327	PF12493	DUF3709		Protein of unknown function (DUF3709)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 30 amino acids in length. There are two conserved sequence motifs: RCLMK and LIEL.	21.20	21.20	21.20	21.20	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.87	0.72	-4.25	9	226	2009-09-22 12:07:19	2009-09-22 13:07:19	3	2	48	0	7	117	0	29.50	76	37.05	CHANGED	hRCLMKpQCVCRCKFQpaCLIEL.psCVVSpFV	...hRCLMKRQCVCRCKFQpaCLIELSp.CVVS.FV.......	0	7	7	7
+12328	PF12494	DUF3695		Protein of unknown function (DUF3695) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 157 and 192 amino acids in length. There is a single completely conserved residue D that may be functionally important.	20.30	20.30	22.00	37.20	19.00	16.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.35	0.72	-4.29	14	77	2009-09-22 12:08:13	2009-09-22 13:08:13	3	3	63	0	46	79	0	102.70	35	46.11	CHANGED	.ssappss+hupp.cPapRLa.ptThuSsRRsstahs......................sphPpDSLDFpLpotYDHpc-hFhsKs-sllQpETlst...................tphRhL+Nst.h.p..pDsl....t+PL+l	................t.satpss+hspp.-PapRLpspsTlsShRRsshahc......................PpIP+DsLDFpLsulYsHHsshFpsKs-lLlppEThpc...................pp.h.p.hlp.stchh....ss............................................	0	16	19	30
+12329	PF12495	Vip3A_N		Vegetative insecticide protein 3A N terminal 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 170 and 789 amino acids in length. The family is found in association with Pfam:PF02018. Vip3A represents a novel class of proteins insecticidal to lepidopteran insect larvae.	25.00	25.00	85.90	85.40	21.30	20.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.24	0.71	-4.59	12	67	2009-09-22 12:19:40	2009-09-22 13:19:40	3	2	11	0	0	62	0	166.50	96	26.51	CHANGED	ALPSFIDYFNGIYGFATGIKDIMNMIFKTDT.GGsLTLDEILKNQQLLN-ISGKLDGVNGSLNDLIAQGNLNTELSKEILKIANEQNQVLNDVNNKLDAINTML+lYLPKITSMLSDVMKQNYALSLQIEYLSKQLQEISDKLDIINVNVLINSTLTEITPAYQRIKYVNEKFEELTF	....ALPSFIDYFNGIYGFATGIKDIMNMIFKTDT.GGDLTLDEILKNQQLLNDISGKLDGVNGSLNDLIAQGNLNTELSKEILKIANEQNQVLNDVNNKLDAINTMLRVYLPKITSMLSDVMKQNYALSLQIEYLSKQLQEISDKLDIINVNVLINSTLTEITPAYQRIKYVNEKFEELTF.	1	0	0	0
+12330	PF12496	BNIP2		Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell.	27.00	27.00	29.50	29.50	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-11.01	0.71	-3.97	17	319	2009-09-22 12:21:50	2009-09-22 13:21:50	3	8	68	0	141	251	1	129.20	46	19.61	CHANGED	cpp+++LsAPp..........................................lsLoL.DpS..................................................................EtShhSD-h.-oss-.........lDls.....lDDL..DTPs-sD.h-h.s...-h-............WEDDhPts.pusptssps...l.phos-.EEcpDs.RhWRslhIG-.QE+RIDM+lIEPYp+VISHGGY.YG-G	..................................................................................................................................................................................................................................................................................................................................................p..hR++LsAPp............................................lsLoL..DtS.....................................................................................-GSlLSDDh.-o.....s...................................Dls..........lD-l..-TPsEs-ph-...s.......ch-.............WE..DDhP..ps..p.sss..tc.......hs-ho...u..-...E.E.p.cDs..RhWRshhIGE..QEpR..lDM+sIEPY++VlSHG.G...Y.YG-G..........................	0	19	31	67
+12331	PF12497	ERbeta_N		Estrogen receptor beta	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00104, Pfam:PF00105. There is a conserved IPS sequence motif.  There are two completely conserved residues (Y and W) that may be functionally important. ERbeta binds estrogens with an affinity similar to that of ERalpha, and activates expression of reporter genes containing estrogen response elements in an estrogen-dependent manner. ERbeta acts as a transcription factor once bound to its ligand and it can dimerise with ERalpha.	25.00	25.00	27.50	27.50	22.20	17.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.64	0.72	-4.22	29	224	2009-09-22 12:23:36	2009-09-22 13:23:36	3	4	124	0	31	209	0	107.90	43	20.22	CHANGED	sPhhhS...ssLsh-.spslCIPSPYsDtuHDas..........slsFYSP...olh...uYut.Pulo-sPo...l+poLSPSlFWPuHuH..hssLsLHs.sQshshp-t.spoPWsEhps..-pslssSppsl	...........Ps.Ys...s.LshE.ptsIhIPSsYs-spH-Ys..........sh.sFYSP...ulhsYu...h.Pu...s...sssss....s+QohSPslhWPo.GH....lSsLslHp.ppuhlY.sEs..+SPWsEs+s.h-Hs.Ls.spps.h....................	0	1	4	12
+12332	PF12498	bZIP_C		Basic leucine-zipper C terminal	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 174 and 411 amino acids in length. The family is found in association with Pfam:PF00170. There is a conserved KVK sequence motif. There is a single completely conserved residue K that may be functionally important. Various bZIP proteins have been found and shown to play a role in seed-specific gene expression. bZIP binds to the alpha-globulin gene promoter, but not to promoters of other major storage genes such as glutelin, prolamin and albumin.	22.70	22.70	22.80	24.60	21.60	22.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.78	0.71	-2.85	28	167	2009-09-22 12:46:35	2009-09-22 13:46:35	3	3	36	0	44	171	0	111.40	34	37.25	CHANGED	TLRAKVKMAE-oVKRlTGhsshh.sh..phsohshs..ss.Ss.ts...sssPhQsssppaat.pssss.shs.........................tptsst.su.shsuschsposuh....p+lA.....uLE.alQ+.RhpuGsssss	.............................TLRAKVKMuEDolKRVhthss.........o.Shshsh.ss.Sss..s..sssPlpDshssaFs.s...sssssshssts....................t.psss.shsu.shsus...cMspsuu...h....p+sA.....uhE.hlQp.thtuh.sss.u..........................	0	7	30	38
+12333	PF12499	DUF3707		Pherophorin 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 147 and 160 amino acids in length. The proteins in this family are frequently annotated as pherophorins however there is little accompanying literature to confirm this.	20.60	20.60	20.70	20.70	20.30	20.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.70	0.71	-3.87	78	350	2009-09-22 12:49:21	2009-09-22 13:49:21	3	15	4	0	307	345	0	144.00	20	42.98	CHANGED	FP...hC........ppstssoPapl....shsssstss.........................................spaCFslpss.........s.ssss....sCC.sss.....LpK..lEhhs.........s....ss..stpssl....sGhsstssssstps.s...s...........sL..................+l....ssLs.hshspssuu.....plCls.lp.................sssolsplC...............sss..sCthu.................................ps..C......CP	............................................................P....p.....pppp.t...sP.apl......s.s.tstss.........................................spaCFplpsh...................................ssssss......sCC..sss.....lpK..lEh.sss..............sC..p....sslt.sssl........sG.h..sthth.t..t.h.t...s........................sl............................+l.ssLs...hshs..pssuu..........plClp.lp..................sssolpphC...................sss...hC.hs.hhs..................tstpC..CP................................................................................	0	97	307	307
+12334	PF12500	TRSP	DUF3706;	TRSP domain C terminus to PRTase_2 	Anantharaman V, Gavin OL	lg7	Anantharaman V	Domain	This domain occurs C terminus to PRTase_2 and has a highly conserved GXXE and TRSP signatures [1]. It is found in bacteria.  These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	25.00	25.00	58.20	33.50	19.80	18.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.21	0.71	-4.75	67	331	2012-10-09 19:35:50	2009-09-22 13:50:58	3	6	324	0	70	262	6	151.80	33	34.43	CHANGED	hstsss...............................................ts...................................hshtsptsa........................GRhGhpssp....s........h....shutp.lphtt......................................c+lLVLGTsEFhahPhhlAcpLppth.............s..VhapSTTRSPIts.....GYAIcsulsFss...s.s.sl.........NalYNVs.............tt.............................................aDc....lllssEs............ssss.s........ssLlptL	...................................ssstt.h.htsttsh.......................................GRhGhhs.t...t.......h.clucplpstt......................s.c+lLVLGTuEFhatPhhLAccLEptu................s..plhapSTTRSPIts......GYAIcssluFsssY.shul........sNalYNVs.t........tp......................................................aDc.lllssEosscshs........stLlptL..............................	0	20	44	60
+12335	PF12501	DUF3708		Phosphate ATP-binding cassette transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 143 and 173 amino acids in length. The family is found in association with Pfam:PF00528. There is a single completely conserved residue P that may be functionally important.	21.70	21.70	21.70	21.70	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.00	0.71	-4.41	84	285	2009-09-22 12:53:06	2009-09-22 13:53:06	3	3	283	0	89	250	468	152.80	29	32.47	CHANGED	lll.lllhLushuahhGRpRAhsh......u..sus.t....LHSLPsYYGhhlAlasslPAlllLslWhhh....pPhllpphVhuplP.......sstshsssphsL........lhucl+slApG................................thslsups.....ssthhsAAppapshpstuphhhssllls..lAluGhsa	......h.ll.hllsluhluahlGRpRAhsl......A.t.GssstplHShPsYaGhaluLhsulPALllLslWsls....pshhlpp.lhuplP.......tst.hstsptsL........hhuplcslAsG.............................................hslusps......pshhlshApthpphpshsphhhsslsls...lAluGhh..........................................	0	30	62	74
+12336	PF12502	DUF3710		Protein of unknown function (DUF3710) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 284 amino acids in length. There are two conserved sequence motifs: DLG and DGPRW.	25.00	25.00	54.70	54.60	19.40	18.30	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.07	0.71	-4.96	59	439	2009-09-22 13:18:44	2009-09-22 14:18:44	3	1	430	0	116	319	51	179.10	38	69.44	CHANGED	GPaDhtpsp......sssssstlDLGulhlPhspGhplplEhs......ps.tt...shulplshspuplpltAFAAP+osGLWcElRtElspulppp.G...........upspt.psGsaGtElhuph.h............................sssh.tshRhlGVDGPRWhLRuVlsGsu...utssp....tAthlcclhppsVVsRGspPhPsR-sLPlp...LPpphs...pphtts	...............GPaDls-hs......ssssssRlDLGSlhlPhhcuhplplchs.........ps.Gs...spulhllpssutlplsAFA.AP+o.....s.....GlWcEVppEl..scuhptp.G............upssh.tsGPaGtElhshl.h...................................................tG..tsu...tssRhlGVDGP.RWhLRuVlsG.u.......uhscp............tuphlc...-hhsshVVcRG-sPhssR-slPlc...lPpshttt....s....................	0	34	84	108
+12337	PF12503	CMV_1a_C		Cucumber mosaic virus 1a protein C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01660. There is a conserved GLG sequence motif. 1a protein is the major virulence factor of the cucumber mosaic virus (CMV). The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strains cause systemic mosaic. The determinant of the pathogenesis of these different strains is the specific amino acid residue at the 461 residue of the 1a protein.	25.00	25.00	32.20	110.20	18.30	17.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.01	0.72	-4.26	11	89	2009-09-22 13:36:50	2009-09-22 14:36:50	3	3	22	0	0	90	0	88.00	68	9.08	CHANGED	RlWshAGGcscsss.cS....Vh-TY+pVDshVNlHassGpWha..PpthcYoVGYN-pGLGPKh-sELYIVspsCVIuNscsLAcuoc	.RIWsMAGGDsKRNSLEGNLKFVFDTYFoVDPMVNlHFuTGRWM+PVPEGlVYSVGYNE+GLGPKtDuELYIVNu-CVIsNS-uLSslT.+.	0	0	0	0
+12339	PF12505	DUF3712		Protein of unknown function (DUF3712)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 130 amino acids in length.	21.60	21.60	21.90	22.20	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.67	0.71	-4.10	72	289	2009-09-22 13:43:24	2009-09-22 14:43:24	3	10	90	0	237	309	1	125.60	19	24.44	CHANGED	sshupltlsthph..sst......shhh.hspphtlsshs......saspaspsllhpcp.hslslpGp...s.p..hphGsl..shpslsh.sKslshp....................G................Lsphp.uhs.................lsshplhhss....ts.........GhNh.husshl....................sNPSslol.pl..G.......slolsl	...........................................................hh.h.hs.hph..t.t........t..h.hst.lplsshs.......sFspa.....sptlh..tspp..hslpl.p.up......s..p.sp....husl...thpslsh.s+slslp....................G................h..ss.hp..uhs...................lsshclstss.....ts....................................uh.sh.pus.ssl....................sNPSs...hol.sl..Gslshp...................	1	97	152	213
+12340	PF12506	DUF3713		Protein of unknown function (DUF3713)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 92 and 1225 amino acids in length. There is a single completely conserved residue S that may be functionally important.	21.90	21.90	21.90	37.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.57	0.71	-4.02	10	36	2009-09-22 13:46:33	2009-09-22 14:46:33	3	1	8	0	10	38	0	97.20	36	13.00	CHANGED	cLssYF..p.lIsc...sKVsscso.........soocpss.sclhTpst-......lcKl+-c.pscl-sKlccaV.sKLKsostPpssYSplILlsspsD....pshossu.huLhuLlslposs.LsNtl++paFssss	.cLspYY..cslI.....sKVuspso.........sospsosssph..pptp......lcKL+-p.Kccl-stlKcaV.scLKlol......Sp.h.lp.p.........p....h...s..t....p.....hh..hh.ps..	0	7	7	7
+12341	PF12507	HCMV_UL139		Human Cytomegalovirus UL139 protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes and viruses. Proteins in this family are approximately 140 amino acids in length. UL139 product shared sequence homology with human CD24, a signal transducer modulating B-cell activation responses, and the sequences in the G1c variant of UL139 contained a specific attachment site of prokaryotic membrane lipoprotein lipid.	25.00	25.00	25.20	35.00	24.10	24.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.53	0.71	-3.95	8	69	2009-09-22 13:50:58	2009-09-22 14:50:58	3	1	17	0	13	66	0	103.10	56	63.02	CHANGED	hs.hpuppphpls+splLAu........pLhhlhohphpCahLhRKlh....................................................psspGpspEtEp+ppchtRahps+tsp.sshhshussh.Sho.s.Qssohts.sp	...Clpu.uGosWsssQLALLAASGW..TLSGLLLLFTCCFCCFWLVRKI.....................................................CSCCGNSSESESKsTH..AYTNAAFTSSDATLPMGTTG.SYTPP.QDGSFPPPPR.	0	1	7	10
+12342	PF12508	DUF3714		Protein of unknown function (DUF3714) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 200 amino acids in length.	20.90	20.90	23.00	22.50	18.40	17.60	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.85	0.71	-4.85	44	464	2009-09-22 14:34:16	2009-09-22 15:34:16	3	4	143	0	56	408	7	192.20	34	48.13	CHANGED	cshshssptsppphssshtp.hs-..pshhssh.spspsttFpThstsp....ppNsIpAslcpspTl..ssGspl+lRLLEshtl.ssthlP+sThLhG.suphpGpRlplpIsSlphsGsIlPVcLsVYDs.DG.pGlaVPsShct-ssKEhuushssuh.....ssshshup.suusQlusshupuslQusSphluK+hRplKVpLKuGap	...........................................................t......ht..pcphlosLt.pshss...tthhtth.sptpshsF...pTssusst......pcNoIpAslcps....p.sl..p-GppV+LRLLEsh..pl....sshhI..P+sohlhG.su+lpG..pRlclpIsSlch.sGpIlPVcLulYDs.D...GQcGlalP..s....S.-hs.As+EluAshuuuh......soShshus..sAss....Qlus-hs+ulhQGsSphluKKhRplKVpLKuGYp..........................................	0	18	48	56
+12343	PF12509	DUF3715		Protein of unknown function (DUF3715)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 170 amino acids in length.	20.90	20.90	25.40	22.00	19.20	19.20	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.94	0.71	-4.39	12	131	2009-09-22 15:00:10	2009-09-22 16:00:10	3	11	42	0	67	140	0	157.60	27	12.42	CHANGED	lpNphLppcastpR..pph+pct+pscEL.-shsFLhhcs.tcstsl......s.........ppGLpss...puKsshLGcsphGVhls..RhuDlhpppshpsu...shs.lhlhKlh+G+hKpl.-s..........spstlsPsPsa-sHl......uc.shsplssphh...ta.pothYhhEh...shs.shhcPpphhP	..............ps.hLppphoppc..pphthstpsspEL.Es.s..hL..hcp.hpsppl...............t...............p+GLpht...ppKhs....hLspPp.shh.s..ph..uDlhpspshpsu..........s.splhh..c...s.hptch.cplt-s.............spsslsssPsa-phl......uc.stsplsshhs..hhsattsthhhhEh...uhs.sphcP+ph.P..................................	0	13	22	31
+12344	PF12510	Smoothelin		Smoothelin cytoskeleton protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.	21.70	21.70	21.90	21.90	20.40	18.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.58	0.72	-4.11	16	284	2009-09-22 15:02:46	2009-09-22 16:02:46	3	6	61	0	105	292	0	50.10	44	9.26	CHANGED	sptps.ppspsssp.hst-l-pIhDEplLc.pLLEssosaEERRhIRAtlRcl+ppc	...............p.....tt.ptt.s..upcl.sh.D.thLc..ph..L-pss-aEER+hIRAAlR-LRppc..	0	16	23	53
+12345	PF12511	DUF3716		Protein of unknown function (DUF3716) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length.	21.30	21.30	22.50	21.70	21.00	20.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.84	0.72	-4.36	50	170	2009-09-22 15:04:55	2009-09-22 16:04:55	3	7	56	0	133	167	0	57.30	30	11.75	CHANGED	Ahhl..QspGppt..sps.CspCp.p...sp.....GP.F..psCV........hhsst.........htsuCuNChasspupp.CShpp	.........AhhhpspGp.s...tpsCppCp..p....sp............GP..F.spCl.........lhsup...........htsuCuNChas....spust.Cohh.t........	0	18	64	110
+12346	PF12512	DUF3717		Protein of unknown function (DUF3717) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 117 amino acids in length. There is a conserved AIN sequence motif. There are two completely conserved residues (L and Y) that may be functionally important.	25.00	25.00	33.00	32.80	21.80	19.30	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.28	0.72	-4.33	29	154	2009-09-22 15:21:54	2009-09-22 16:21:54	3	2	113	0	59	128	14	70.90	44	76.54	CHANGED	M.ss..lpIs-lEuAINaWRs+pPS....s-thsLssEupALA-lYAlMIhp+pspls.ssLsststsAhtuahpsp	........ssIoIp-lEAAINaWRuRuPu...ssD-ltLCsEAsALAcsYALMIsp+psslsh-uLsscARsAapuah...p..	0	3	17	40
+12347	PF12513	SUV3_C		Mitochondrial degradasome RNA helicase subunit C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.	21.60	21.60	21.80	24.70	18.90	21.30	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.32	0.72	-4.52	83	441	2009-09-22 15:25:28	2009-09-22 16:25:28	3	7	383	2	272	424	7	48.20	30	6.89	CHANGED	LppLEshachlslYhWLShRa.sshFs-tphspch+ptlpphIpptLpph	...LhcLEshachlsLYlWLShRF..sh..FsD.tphspch+ptlsphIpptLpp.h........	0	83	158	225
+12348	PF12514	DUF3718		Protein of unknown function (DUF3718)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important. 	22.50	22.50	22.70	31.90	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.95	0.72	-3.92	41	115	2009-09-22 15:28:03	2009-09-22 16:28:03	3	1	56	0	58	113	27	68.90	32	56.60	CHANGED	lCcsstosshhpL++phK..........cp+l..............ph+plastlsCNGpSlhpFAhsps..Ascsuphl..........htphshp-lussp	..lCchltusc+scLR+plK..........-pRl..............+h+plasulsCNGpSLlcaAhtss..Ascsupal..........spplshp-Lu...........................	0	7	19	40
+12349	PF12515	CaATP_NAI		Ca2+-ATPase N terminal autoinhibitory domain	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF00689, Pfam:PF00122, Pfam:PF00702, Pfam:PF00690. There is a conserved RRFR sequence motif. There are two completely conserved residues (F and W) that may be functionally important. This family is the N terminal autoinhibitory domain of an endosomal Ca2+-ATPase.	21.70	21.70	28.50	27.80	19.90	18.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.31	0.72	-4.45	28	163	2009-09-22 15:29:38	2009-09-22 16:29:38	3	12	30	0	103	162	0	46.50	48	4.79	CHANGED	hhpcsF.-ltu.........KN....uStEuLpRWRpuss..lVhNspRRFRhssDLsKcs-s	....hp-sF.-l.u..KN.............uStEsLcRWRpAs...lVhNspRRFRaTsDLcKcpEh......	0	13	62	85
+12350	PF12516	DUF3719		Protein of unknown function (DUF3719)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important.	20.60	20.60	20.70	20.60	19.30	17.70	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.21	0.72	-4.41	14	139	2009-09-22 15:30:52	2009-09-22 16:30:52	3	2	57	0	72	128	0	64.50	40	12.14	CHANGED	hLaEG+sss..t..spsLppECppWss...+hPHLRlhGsQhhtPpccGapah.....susshp.pshhutssssss	............hLaEtKlus..p..TpuLppECppWss...paPHLR..lLG+QllhPtsEGapha..ussssSssp.cs..s.ttp...s......................	0	16	24	39
+12351	PF12517	DUF3720		Protein of unknown function (DUF3720) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. There are two completely conserved A residues that may be functionally important.	25.00	25.00	25.00	31.40	22.80	24.70	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.39	0.72	-3.30	38	82	2009-09-22 15:31:52	2009-09-22 16:31:52	3	1	2	0	19	82	0	93.20	33	25.57	CHANGED	KAVEAuEss..ELuussss.pc..p-sossstl.ssTpusuAPGsGG..tGVAGtsss......hP.ssPGGSsTtspptp..pslsspGscpss.cpspp-upsops..Q	.....KAVEAu-uu....pLuussss.ps..pcp.sstpl.ssTpusuAsGs..GG..suVAGt...ssss.....hP.ssPGsSsTttpp.tc..pslsspsscpsstcpsppssptsts..............	0	0	0	19
+12352	PF12518	DUF3721		Protein of unknown function	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. There is a conserved WMPC sequence motif. There are two completely conserved residues (A and C) that may be functionally important.	21.30	21.30	22.80	27.80	18.50	20.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.45	0.72	-7.68	0.72	-4.35	41	73	2009-09-22 15:33:12	2009-09-22 16:33:12	3	4	30	0	26	80	320	33.70	46	32.13	CHANGED	asTctEAEppApc.hGCpGuHpM..Gs.pWMPCss...atp	.....asT+tEAEppAtc.hGCpGsHpM...Gs.pWMPCspHt......	0	2	10	20
+12353	PF12519	DUF3722		Protein of unknown function (DUF3722) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 415 and 473 amino acids in length.	25.50	25.50	34.20	35.60	23.20	25.40	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.77	0.70	-5.17	31	140	2009-09-22 15:34:49	2009-09-22 16:34:49	3	2	135	0	105	160	0	252.20	37	58.90	CHANGED	l+lplSshuTPphtooasLushsh..lsGSloYLaoossLpp..stsSpplsLpchlpsYRhlp..sshs.ppp..p..htsh.t.......................................oLLYGRhal.PsopLEAhhl+RlSPssQlhlpslSs.t..........................................................................sssuslhshlQ+DoG+aspEalaSTs-uLhGaRsLaNFGssssptt.....................s.hssp.....................plSsGuEhaauslspSsGhSTulRasThsssTsp................................PhTlTLohNPlhGplSoT.Yol+sSsshshsSRaDFN	........................................l+lplSshuTPphsoSa....sLushsh......lsGSlSYLaSohsLpp......stpSsplsLpchlpuYR.lp..ssht.t...tt...t...t......ts...s.tt........................................................toLLYGRhal.PsopL-Ahhl+RloPshQl.ltslSs.t..........................................................................tstuslhs.lQpDs..G+aspEhlaSTssuLhGaRsLaNFGssspp.ss.....................................p.p..............hs.....hlSsGuEhYYuslspSsGhSTGlRFsTlPsssup...................................................PhThTLolNPLhGplSoT.YolpsusshuhsoRa-FN.........................	0	27	56	88
+12354	PF12520	DUF3723		Protein of unknown function (DUF3723) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 374 and 1069 amino acids in length. There is a conserved LGF sequence motif.	21.30	21.30	21.60	21.30	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	511	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.35	0.70	-6.01	20	202	2009-09-22 15:35:55	2009-09-22 16:35:55	3	6	44	0	161	209	1	265.00	18	50.16	CHANGED	C+RL-spN+lsAllScpsLstALppuslotssLh..sspp.PpLpFstG.plpCLHG+HRlpAup-h....Lssu.D+WWsVDLYhD.................slup-L+suLhEEYuNp+psoDGEIYR+IRpYp..........p-sNtthppRWhuRL.osppt+hhp...................h.thht.uhulspLhchhuLhss.......................EllpYLs.pltchWu.llss-.st.....ht+lDscTVctLEhhuPthSctDuptlpslltuGplFssFsp.sERpslhccLp...shcGlIPSLaTFFcDhcYLEsCAcsl++Lls.s..p.olppshpthas.tssss..pptllQooEsshpp...ppsusspph-luY+QlWLaAMRaasphspsst....pcshhs+sspppuDppsla-hAsLAp+LGFpSspIcsLhspuscRp.hApthLhpARps-tYpYsssph-slVp+IV-shssA.h.ppht.sschhsspssph+s.....RCGhPptpupcpD+chLFlDclautpssssshl.TohhVRRslaFAFFG	.................................................................................................................................................................................................................................................................................................................................................................................h................hs..sl..lp.............h.....h.tt..hh........h..h...h.....h.......l.oh..h.tsh.hht.....ht.h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	12	47	136
+12355	PF12521	DUF3724		Protein of unknown function (DUF3724) 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF00073. There is a single completely conserved residue Y that may be functionally important.	22.00	22.00	22.50	22.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.66	0.73	-7.06	0.73	-3.91	5	178	2009-09-22 15:37:19	2009-09-22 16:37:19	3	11	6	0	0	111	0	22.90	88	6.99	CHANGED	RupGcVVcDYSRYosAosssst-	.RSQAYMVKNYPTYSQTITNTATD..	0	0	0	0
+12356	PF12522	UL73_N		Cytomegalovirus glycoprotein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 30 amino acids in length. The family is found in association with Pfam:PF03554. This family is an envelope glycoprotein of human cytomegalovirus (HCMV).	20.30	20.30	22.80	22.80	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.95	0.72	-6.99	0.72	-4.40	5	115	2009-09-22 15:38:45	2009-09-22 16:38:45	3	1	5	0	0	82	0	25.90	67	19.32	CHANGED	LGLLVLSVAAGSSGNNSSTSTSATTsS	.LGLLVLSVsAuS..NNoSTuoososSS.	0	0	0	0
+12357	PF12523	DUF3725		Protein of unknown function (DUF3725)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01577. There is a conserved FLE sequence motif.	20.80	20.80	21.10	112.00	20.60	17.50	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.48	0.72	-3.89	4	55	2009-09-22 15:39:49	2009-09-22 16:39:49	3	5	5	0	0	51	0	73.90	79	5.45	CHANGED	ahoEFclScGAKILQLV.IGsAElGRsFLEGs+hlRAsIFEIl+KTMVG+LGYDF-sELWhCHsCspTS-KYFK	YsSEFcISKGAKILQLV.IGNAEVGRTFLEGNRFlRANIFEIIRKTMVGRLGYDFESELWhCHNCscTSEKYFK	0	0	0	0
+12358	PF12524	GlyL_C		dsDNA virus glycoprotein L C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is typically between 55 and 80 amino acids in length. The family is found in association with Pfam:PF05259. This family is the C terminal of glycoprotein L from various types of double stranded DNA viruses (dsDNA).	20.10	20.10	28.70	26.80	18.60	17.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.08	0.72	-4.06	10	48	2009-09-22 15:41:28	2009-09-22 16:41:28	3	1	20	1	0	45	0	70.40	44	32.42	CHANGED	uuStsPVssGCVNh-hS+sRpChGpsshshFscsphhpP.susDD...............hs.uRtssc+s+ssRupss+	..........AuSpsPVtuGCVNh-YSRsRpChGppcLGhhNtspsppPshssDDEAu.Qs.s.ss.ss.hA.ScssP+RssAs+u+pp+..................................	0	0	0	0
+12359	PF12525	DUF3726		Protein of unknown function (DUF3726) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length. There is a single completely conserved residue E that may be functionally important.	22.10	22.10	22.10	22.40	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.42	0.72	-4.18	34	82	2009-09-22 15:42:57	2009-09-22 16:42:57	3	1	79	0	18	89	671	78.10	31	33.98	CHANGED	hhShNEltuhspKAhcGhGhshG.A--sAphsthLphhG....LsGsptLsssLphhsspssssl.s.h................hpsss.hhsstpshss	.....hShNEl.AhspKAhhGhthshGpA-thAphls.LphhG....LsGlpphspshphhshpsspsl.s...................tsss.h.hsh+t.S.................................	0	5	9	15
+12360	PF12526	DUF3729		Protein of unknown function (DUF3729) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with Pfam:PF01443, Pfam:PF01661, Pfam:PF05417, Pfam:PF01660, Pfam:PF00978. There is a single completely conserved residue L that may be functionally important.	25.00	25.00	43.00	25.30	22.40	24.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.55	0.71	-2.72	39	273	2009-09-22 15:48:27	2009-09-22 16:48:27	3	10	14	0	0	277	0	99.30	46	9.34	CHANGED	HhW..........ESANPFCGESTLYTRTWSsSGFSSsFSP.Essssssssssshsps....sPP.ssslhs.PPssEpssssss.ssssspP..ss.............ssuss..sPss...PsppsspPs.......u.pRRLLaTYP	...................HhWESANPFCGEuTLYTRTWSsSGFSSsFSPPEsuhsssssssthsps....sPs.ssshhs.PPssEpstsssssssssscP..ss.............ssuss......sP.s....PspcsssPs.......uppRRLLaTYP.......................	0	0	0	0
+12361	PF12527	DUF3727		Protein of unknown function (DUF3727) 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length.	21.50	21.50	21.90	21.90	20.10	20.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.39	0.72	-3.91	34	108	2009-09-22 15:50:23	2009-09-22 16:50:23	3	2	94	0	49	109	114	97.90	35	44.90	CHANGED	pcLpLh+oAh.TLTVsGELs.h----l.ph-.-c-.....tc.-sEp..hphLso.Fhh--pEYulYsPLDPhhhlA+..hss.spspLlss-Ehc....clpPll...EppLh-ch	...........................cLpLhcoAh.sLTVpGELs.hp---l.phc.-s-t....sc.-sEplElLss.Fh.h-spcYulYTPLDPlLhlA+..hsp.sps.Ll.ss-Ehp....plpsll...EppLhpt.h.......................................	0	13	33	44
+12362	PF12528	DUF3728		Prepilin peptidase dependent protein C (DUF3728)	Gavin OL	lg7	Prosite	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 106 and 121 amino acids in length. The family is found in association with Pfam:PF07963. There are two completely conserved C residues that may be functionally important. This family is frequently annotated as prepilin peptidase dependent protein C.	22.50	22.50	31.20	30.60	20.20	16.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.97	0.72	-3.59	24	542	2009-09-22 15:52:35	2009-09-22 16:52:35	3	2	530	0	39	167	1	74.80	63	69.32	CHANGED	YpQsLhpuFsphaQ.RQsW+hhaQph-hhs.s...............sssWQhpphpsp......pusCsploVplhoPtsppuploRhaCssp	..aQRsLMsShASRsQYpQLWRauWQQTQLpuhS....................PPssWQVNRMQTS......QAGCVSISVTLVSPuGRpGEMTRLHCPNR..	0	2	8	23
+12363	PF12529	Xylo_C		Xylosyltransferase C terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 169 and 183 amino acids in length. The family is found in association with Pfam:PF02485. There is a single completely conserved residue G that may be functionally important. Xylosyltransferases are enzymes involved in the biosynthesis of the glycosaminoglycan linker region in proteoglycans.	25.00	25.00	25.60	25.10	23.50	16.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.04	0.71	-4.90	24	190	2009-09-22 15:54:46	2009-09-22 16:54:46	3	6	82	0	97	161	0	172.10	45	21.16	CHANGED	-paLaGpYssssPsL+uYWpNlYcp..D.shsuhsDstlohhpShhRluhpp..t......tptts+hcsht...shplphYhpcDpFpG....aLV+acu............t..sstpt.pLEsaltPpsshplspts..ptupRLpsl..-..VGT-aD.KEplhRNaGtllGPpsEslhht+Wutut...........shssTllWIDPhthlAss	...............................................D.aLY.GsYPsGTP.uL+uYWENlY-p.sD.GhsuLSDlhLThYpuFuRLuL++stssht...sptpC..RatPhG..hPsSVHLYFhsD+FQ.G....aLl+pps.............ps..AsuphEoLEsWlhPppshKlssss...sphsRLQph...E..VGT-WDsKERlFRNFGGLLGPhDEPVuhQ+Wu+Gs...........NlTsTVlWIDPssVlAs.......................	0	20	26	57
+12364	PF12530	DUF3730		Protein of unknown function (DUF3730) 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 220 and 262 amino acids in length.	25.00	25.00	29.80	25.10	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.49	0.70	-4.44	25	180	2009-09-22 15:55:45	2009-09-22 16:55:45	3	7	96	0	122	185	0	222.30	20	24.00	CHANGED	hlhhLhht.......htcsssschhhphLpsLssLuspp............hth.hllpslssLspssstph..................................hthcLlsplatpss+ta.....shLpthLt.......tsspssppphchtluhssoh+slCptpPp............+us-llthlstsL.........pppssl.....................................spuhul-ulpslC............pscll-hhssWplltpcl......s.p.cP.lhp...........................phh.ll..hthsstphsp........hpppslpllWchhstpc.......spsphhshpuL	...................h....hhht........tc.ppsph.hthLphLsphsspc.......................................sshshhlpslthLsspsphph........................................hh.pLlstlhptpspha.....shLpth...hth...p..p..t.s.p.....p.p...........ph....cphhuht.ssh+slCptpsp............pus-hlttlothl.........ppssts.....................................................................spuhslphlpsLh............pupllshtstW.psLtt.pl.......t.t.ps.h..............................phh...Lhsththsp.tphpt...............hp.pllphhWphstp.p.......h.s..hh.....................................................................................................................	0	30	47	81
+12365	PF12531	DUF3731		DNA-K related protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 250 amino acids in length. There are two conserved sequence motifs: RPG and WRR. The proteins in this family are frequently annotated as DNA-K related proteins however there is little accompanying literature to confirm this.	25.00	25.00	145.50	144.60	24.00	22.70	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.65	0.70	-4.85	38	220	2009-09-22 15:58:22	2009-09-22 16:58:22	3	2	219	0	66	205	15	247.40	51	26.58	CHANGED	SAcHERhWLNLAGaCLRPGFGsslDsWRlpQlWslaspGlQasp-sQsWs-WWshWRRlAGGLspspQtplhc....slA.hLpss.stpptph...ts...pttuhp-MlRLuAuLERlssppKhcLupalLpR...Lp+ss...............tstptW.WALGRlGARpPhYGSsHpVlPscpsppWlstL...LphD.W+c.t......suFAssplARhTGDRsRDLs-shRppVlc+LcsspAspsWlphVpEl.spL-ps-ppRlFGEuLPsGLpLl	............StsHE+sWLpLAGaCLRPGFGcshDuWRIEQlWsLYpQGIQas.ssQsWo-WWlhWRRlAGGLsp-QQpplLs....-IApaLpPuuh+...sstts....pcu...pctGY-sMVRLuASLE+LtVEcKs.LupWhLs+...Lp+sp................ppspW.WALGRLuARsPhYGStHsllPtEpsppWLspL...LcpD......Wpcps.....hsAFAsV.hsRhTGDRsRDls--hRppVlc+L+po+ss-uWlshVpEV..l-L-cu-opRsFGEoLPsGLpL.........	0	20	31	53
+12366	PF12532	DUF3732		Protein of unknown function (DUF3732)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is typically between 180 and 198 amino acids in length. There is a conserved DQP sequence motif.	25.00	25.00	35.00	34.80	24.80	22.40	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.24	0.71	-4.78	50	147	2009-09-22 15:59:45	2009-09-22 16:59:45	3	5	141	0	42	122	9	187.10	30	30.98	CHANGED	pplppLcppls.tpshpp+h..psshsplsph.hschupplchEps...stslchshcphsl......hhsspscphhL......pchGSGuNWluhHlshaLALHcaFhpp.....ppslP..shLhlDQPSQVYFPs........tpshstppl.........................................pDpDhtuVpchFphLsphspchpt......phQlIVh-HAs.pt....p.htsshh.ppWR..pscuLI	.................t.plptLctpls....pc...hpc+h...ctthsplsph.hschhtpLchEps...ssslphshc.phsl......hhspsscphhL......hclGSGuNWLuhHlulhLALHpaFspht....sssVP..saLlhDQPSQVYFPs...tttts.cp.pclt........................................pD-DlhsVcclFphlsphhpctpp......shQIIVh-HAspp.htth.....pshh.pcWR..psptLI..............	0	16	23	32
+12367	PF12533	Neuro_bHLH		Neuronal helix-loop-helix transcription factor 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found C-terminal to Pfam:PF00010. There is a single completely conserved residue W that may be functionally important. Neuronal basic helix-loop-helix (bHLH) transcription factors such as neuroD and neurogenin have been shown to play important roles in neuronal development.	25.00	25.00	26.20	25.20	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.83	0.71	-3.30	21	229	2009-09-22 16:01:00	2009-09-22 17:01:00	3	3	65	0	114	175	0	119.40	49	36.79	CHANGED	G+pPDhluFVQsLCKGLSQPTTNLVAGCLQLNsRshLs-p.tsctusp...ssusasspsasY......psP....tLsoPs....tsoh.....susH.h+.....stsYtush-shat.....ssss-tsoPpa-G..sLoPP.lslsGsFS	.....GKpPDLloFVQsLCKGLSQPTTNLVAGCL......QLNsR.sFLh-Q.st-tss+..........ssusassHs.asY.......pSP....tLsoPP........aGsh.....ssoHsh+.....sasYs.u.u.hEshat.........usss-ssSPpa-G..PLSPP..lslNGNFS................................................	0	12	22	56
+12368	PF12534	DUF3733		Leucine-rich repeat containing protein 8 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00560. There are two completely conserved residues (W and Y) that may be functionally important. Many of the proteins in this family are annotated as leucine-rich repeat containing protein 8 however there is little accompanying literature to back this up.	25.00	25.00	50.80	35.60	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.23	0.72	-4.68	22	480	2009-09-22 16:01:50	2009-09-22 17:01:50	3	39	44	0	283	366	0	62.00	36	15.95	CHANGED	Mhsls-hppas.tpQssY+lLKPWWDVFhsYLsllMlhlulhuushth.t.phh.ChPs.pspthppp	...........hssh-hpQas..sQssY+lhhPWashahsYLsllhhhIhlhuush.h.......phPs.psuphpp........	0	16	46	119
+12369	PF12535	Nudix_N		Hydrolase of X-linked nucleoside diphosphate N terminal 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 847 and 5344 amino acids in length. These enzymes hydrolyse the molecular motif of a nucleoside diphosphate linked to some other moiety, X.	20.60	20.60	20.60	28.30	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.86	0.72	-4.51	85	803	2009-09-23 12:17:57	2009-09-23 13:17:57	3	4	787	4	107	492	28	56.60	37	27.66	CHANGED	ppphLcaAtclQulAQuGLsYu+DsaDhERY-clRcIus-hhuptoslshcplcsLFs	....t..calcahpcl.ulupsGLsYo....K.DsFDpERYccLRplss-Mluphoch.sh-pltplh...............	1	39	72	90
+12370	PF12536	DUF3734		Patatin phospholipase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF01734. There are two completely conserved residues (F and G) that may be functionally important. The proteins in this family are frequently annotated as patatin family phospholipases however there is little accompanying literature to confirm this.	22.00	22.00	22.00	24.10	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.29	0.72	-3.93	64	300	2009-09-23 13:23:11	2009-09-23 14:23:11	3	7	189	0	108	296	13	105.30	29	24.71	CHANGED	IpYSSRTRhpo-thcphpphRcslpcLhp+lPtph+s.-Pthptltphus..ssthsllHLIYpppshEsps.KDa-FSptohc-+WpuGhcDscpsLp..c.pWhptsssspG	...........................IpYSSRTRhsT-hhpphpchRpslccllp+lPt..p.+p..c.........s.....h..pthtphus..ssphsllHLIY..ppcshEspt..KDY-Fotsohp-+WpuGhcDhcpsLs..p.phhthsp..................	0	18	49	76
+12371	PF12537	DUF3735		Protein of unknown function (DUF3735)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved LSG sequence motif. There is a single completely conserved residue G that may be functionally important.	22.10	22.10	23.10	27.40	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.06	0.72	-3.93	46	266	2009-09-23 13:55:43	2009-09-23 14:55:43	3	8	220	0	188	278	2	71.80	38	14.39	CHANGED	tshhhhcphls+lullGlTlhAlLSGauuVssPYphhs.........hhhc.ss............ct..clpshpppltpotshltpK+p..clp	.........shhshcphloRlGVIGVTlMAlLSGFGAVssPYshhs.........hFhRsls............-s..DItshE+pLhpTh-hlhsKK++l.........................................	0	64	103	153
+12372	PF12538	FtsK_SpoIIIE_N		DNA transporter 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 107 and 121 amino acids in length. The family is found in association with Pfam:PF01580. The FtsK/SpoIIIE family of DNA transporters are responsible for translocating missegregated chromosomes after the completion of cell division.	21.50	21.50	21.70	22.30	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.19	0.71	-3.97	18	321	2009-09-23 14:46:06	2009-09-23 15:46:06	3	4	319	1	22	218	0	107.70	40	7.71	CHANGED	hLhlhYppplp+hcLss...pcsloIGsshcsslTlssL...cpsIpLchcps.......hhphptpsLthscshplshttp.hhhhahspsppsplYsluscpplsluspct..sDIslpssps	........hLIIpYscpL+hhsLcs...sKohTIuc--+ADITLpSL...uEsIcLcpNN........pGshQsscsslNK.slshcs..sh-shpL.LYopsshsuhhasuhp-ohTIGsNsY..DDhsIpuh.hs.....	0	5	11	16
+12373	PF12539	Csm1		Chromosome segregation protein Csm1/Pcs1	Mistry J, Wood V	jm14	Manual	Family	Saccharomyces cerevisiae Csm1 is part of the monopolin complex. Csm1 forms a complex with Mde4 and promotes monoorientation during meiosis [1].  Csm1 also plays a mitotic role in DNA replication [1].  This family also contains the Schizosaccharomyces pombe homologue to Csm1, Pcs1.  Pcs1 forms a complex with Mde4 and acts in the central kinetochore domain to clamp microtubule binding sites together [3].  The two complexes (Csm1/Lrs4 and Pcs1/Mde4) contribute to the prevention of merotelic attachment [3].	22.60	22.60	22.70	23.10	22.40	18.30	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.09	0.72	-3.50	29	121	2009-09-23 14:54:00	2009-09-23 15:54:00	3	4	118	16	91	114	0	91.60	39	22.85	CHANGED	hplpcDLap...pLTGlplpssccc..-sshhFDshQoupN..G.......slca+Lsls+sts............tp...........sEhpYhPhL.......cppp-c...............pLhchLP-YLp-sloFPhpp	....................u.plpcDLYpcLTGLhl+ssccc..-sshlaDClQTGpN..G......................sl+aKLulspsps............ps................sEhpYhPhLcpsc-c......................pLhclLP-YLs-sloFPhp.................	0	17	45	77
+12374	PF12540	DUF3736		Protein of unknown function (DUF3736)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 135 and 160 amino acids in length.	22.60	22.60	27.30	23.30	21.40	19.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.72	0.71	-3.95	10	166	2009-09-23 15:32:06	2009-09-23 16:32:06	3	3	65	0	89	153	0	140.60	30	24.34	CHANGED	psccshuSclshEup.........+lppPtpcauusspss+cSs...s.lhVssss+uVssoPPlsp.sss+plphlhcsstps.ppscph.cup.hhRcRhl..........scss.sp+.......psttss.........sPu...hspshshthoPs..shsQ-schQs.p.....lsLs+	...........................................t..p.hsSclshEpp.........+hppstEc..u.h.s.ccss...s..tV.sth+sVs-pPPlsp.sso...cplphlhh.t..p.ppt-ph.pspptt.RcRhl............................csP.stp...........htst.s.................sPu.....t.sh..shthoPs..phspssphp........hsL...........................................................................................................................................	0	12	22	50
+12375	PF12541	DUF3737		Protein of unknown function (DUF3737) 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 281 and 297 amino acids in length.	22.10	22.10	22.60	32.90	21.20	22.00	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.00	0.70	-5.42	36	223	2012-10-02 14:50:22	2009-09-23 16:35:19	3	2	209	0	39	195	4	258.30	45	96.08	CHANGED	MppIcpphasGERALFss+shplpsshFs...DGESsLKEo+NIplpsshFchKYPhWascslplcssphp-huRAulWYopslphpsoplpAPKtFRcspslpLcssshssAtEThWsCcslplcssps.pGDYFhMsSpNlhl-slpLsGNYuFphs+NlEl+NuclhSKDAFWNsENVTVhDShIsGEYLGWpS+NlThlNCpIpusQsLCYh-sLslcNCchl.sTcLAFEY.SsV-AsIsusIsSVKNPhSGpIpAcpIGclIhDcsplss.spspIhsp	....Mp.IcpphasGERsLFstcDhplpsssFs...cGESsLKEspNIphpsshFchKYPhWascshplcsshFpphuRuul.WYopslphpsohlpAPKhFRcspslpL-NVphssApEThWpCcslplcNlph.pG-YhhMpSpNIhlDslp.sGpYsFphs+NVEl+NuplhoKDAFWpsENVTlYDS.lsGEYLuWpS+NlphlNCpIpupQsLCYhcsLshcNCphh.ssDLAFEY.SslpAsIpusIpSlKNPhSGpIpAcplGplIhDcsthss.spspl..t.............	0	12	23	31
+12376	PF12542	CWC25		Pre-mRNA splicing factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.	26.10	26.10	27.20	27.20	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.02	0.72	-10.59	0.72	-3.54	62	293	2009-09-23 15:39:42	2009-09-23 16:39:42	3	5	251	0	220	284	0	95.10	32	23.98	CHANGED	c..cctp+l-........WMYpss.................ttttpppE-YLLGK......pclD.phlppppttptpthsptpt..............................sstp-thsKl.p-DPLhtI..KppEppthpthhpss	..........................p+pc+L-........WMYpuP...................ssttppE-Y..LLG+.....plDph.lt....ppp...pp..ctptsuspssh...h..ss....................................sottDhtsKl..+EDPLhhI..++pEppthcthhpsP.................	0	73	122	182
+12377	PF12543	DUF3738		Protein of unknown function (DUF3738)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 457 amino acids in length.	21.90	21.90	23.40	24.90	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.18	0.71	-4.73	49	107	2009-09-23 15:51:44	2009-09-23 16:51:44	3	9	14	0	98	138	12	196.00	27	60.42	CHANGED	LpsllthAYslp....shQ.lsGPsWl........ssc+..aDlsA........Kh.....Psuss........pc......ph.tMLQsLLs-RFpLshH+Eo+chslYsLsluKs....GsKl+tsssssssstss.............................................tttphpspphshstLAc....hL.....u..phhs....pPV.lDpTGLsGpYDhsLpas.pt........................................................sssssslhs.AlpcQL...GLKL.cscKtPl-slVlD+sc	.............................................ttllthAYslp......s.ph....h.suPsWh........ssp+..aDl...A...........+s...........ss.sss..............pp................phptMLQsLLs-RF.pLphHpEs+chssYsLsluKs....GsKLctsps.sssss.s.s..............................................tstphpspshshsplup............hL.........s.....thls...cPV.lDpTGLsGpYDhsLpassps........................................................sssssslhs.AlpcQL...GLKL.cspKssl.-slVlD+h..................................	1	74	98	98
+12378	PF12544	LAM_C		Lysine-2,3-aminomutase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is typically between 111 and 127 amino acids in length. The family is found in association with Pfam:PF04055. LAM catalyses the interconversion of L-alpha-lysine and L-beta-lysine, which proceeds by migration of the amino group from C2 to C3 concomitant with cross-migration of the 3-pro-R hydrogen of L-alpha-lysine to the 2-pro-R position of L-beta-lysine.	26.70	26.70	26.70	26.90	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.52	0.71	-4.09	14	526	2009-09-23 16:00:04	2009-09-23 17:00:04	3	8	452	4	212	447	50	90.00	46	21.48	CHANGED	IEuLRGHTSGYAVPTFVVDAPGGGGKIslpPNYlISQSs-KVVLRNFEGVIToYPEP-sYhs.....tps-shFtph....tpcpp.hGluuLhs-..c.phuLsPcsLpRh-RRcth.tp.ttpohKcpRc++-	......hEuLRGHTSGhAVPTaVlDAPGGGGKlPlh.P.s.Y.l...lS..p.....u...ss+.l...lLRNaEG.hlssYs-..P..t................................................................................................................................	0	97	161	189
+12379	PF12545	DUF3739		Filamentous haemagglutinin family outer membrane protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF05860.	20.50	20.50	21.20	48.10	18.30	19.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.48	0.71	-3.95	24	96	2009-09-24 09:08:12	2009-09-24 10:08:12	3	4	63	0	46	104	5	111.90	55	3.05	CHANGED	GGDIhhWSupGDIsAG+GuKTslsssPsph..l.......hDsp.Gssp...ls.sussoGuGIusLpshss.......s.tsGsVsLlAPpGslDAG-AGIRsuGNlsluAhpllNAsNIp.VsGsssGlPss	.GGDIhsWSupGDINAGRGSKTollhsPP.+t..l.......YDsh..GNVo....LsspsPuoGAGIATLsslP-........l..ssGDlDLIAPhGTIDAGEAGIRVSGNlNlAALpVlNAuNIQ..l.pGpooGlPs.......	1	3	17	26
+12380	PF12546	Cryptochrome_C		Blue/Ultraviolet sensing protein C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 113 and 125 amino acids in length. The family is found in association with Pfam:PF03441, Pfam:PF00875. Cryptochromes are blue/ultraviolet-A light sensing photoreceptors involved in regulating various growth and developmental responses in plants.	22.80	22.80	23.20	23.10	19.80	22.70	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.09	0.71	-3.42	20	114	2009-09-24 09:12:39	2009-09-24 10:12:39	3	3	39	0	22	110	0	116.80	39	20.11	CHANGED	sPIuFPp-lp.MEhc+p..PlR.ss.........sshs..RRhcDQMVPoM.T......SSlhRs.p-pEhSu-h..pssu..tD.oRAEVPsph..h...........tspsppcphhspssspss.............hppppsh.p..pphhttt.htsSTuESSSShp	....sPIsFPp-lp.ME.scp..PsRsss.........hsss..RRhcDQMVPSh.T.......SSllR...s...p-pEhSsDh..pN.s...s-SRAEVPpsh..h...........psptppc-slspshspss..............ppppsh..t.phppphtttshtsSTuESSSShp....	0	3	10	16
+12381	PF12547	ATXN-1_C		Capicua transcriptional repressor modulator 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 49 and 781 amino acids in length. There is a conserved IQT sequence motif. ATXN1 directly binds Capicua and modulates Capicua repressor activity in Drosophila and mammalian cells. The polyglutamine expanded mutant type of ATXN-1 does not bind Capicua with as high affinity as wild-type ATXN-1. It is associated with spinocerebellar ataxia type 1 (SCA1).	25.00	25.00	25.80	27.40	22.90	23.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.50	0.72	-4.00	5	77	2009-09-24 09:15:23	2009-09-24 10:15:23	3	2	60	0	27	69	0	39.00	78	8.02	CHANGED	GLpLGKPVSRSsShosppS.th.....p..p.tu.VsolSPHTVIQTThsuoEuLP	..GLHLGKPGHRSYA...........................LSPHTVIQTTHSASEPLP.....	0	1	4	9
+12382	PF12548	DUF3740		Sulfatase protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with Pfam:PF00884.	25.00	25.00	30.50	30.50	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.89	0.71	-3.92	21	188	2009-09-24 09:16:27	2009-09-24 10:16:27	3	4	75	0	95	159	1	142.50	43	16.51	CHANGED	hptpas+pRppRul.hch....-splhclshE....cc.hph.pshslhccH..............pccsc+-spp.ssss........sssssshhss.pplpsTh............................................RCalhsN.DpVpCssslYcstcuWKcp+spIDt.IcsLpsKIpsL+El+tpLKcp+Pppssss+t	....................................................................................................+spas+sRptR.S.lu..lEh....-GplYclsL-...ptt.....psRslsKRH..............tcpscp.ch...t..s...sGss.............hhsss.sthussssl+VTH...............................................................................+CaIL.N.DTVpC-p-LYpShpAWKDHKhaID+EIEsLQsKIKNLREVRGHLK++RPEECsCsK.........	0	12	19	56
+12383	PF12549	TOH_N		Tyrosine hydroxylase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. Tyrosine hydroxylase converts L-tyrosine to L-DOPA in the catecholamine synthesis pathway.	21.10	21.10	23.20	21.20	20.70	20.80	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.35	0.73	-6.60	0.73	-4.23	7	141	2009-09-24 09:17:42	2009-09-24 10:17:42	3	8	42	0	40	141	0	23.40	47	13.09	CHANGED	PTPshuoPphpGhRpAVSEhDsKQA	................shsSPphhGhRpul.E.stKpt	0	3	5	14
+12384	PF12550	GCR1_C		Transcriptional activator of glycolytic enzymes	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.	21.70	21.70	23.30	27.10	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.81	0.72	-4.11	69	275	2009-09-24 09:19:23	2009-09-24 10:19:23	3	11	71	0	192	269	0	79.80	27	13.55	CHANGED	paphs+shpoVt-lacEahpG..htGpPulpph......-pcaG.spWR....ssppp..phap+RKhlhchIpp............shp.cshstppslchlEphR	.......achs+s.poVh-lacEahtG.......ltGpP..olcpl......-cpYG.spWRt...sspcp......+has+.....R+hlhchIpp.................s.p.pshshppslphlEphR.......................................................	0	38	111	186
+12385	PF12551	PHBC_N		Poly-beta-hydroxybutyrate polymerase N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with Pfam:PF07167, Pfam:PF00561. There is a single completely conserved residue W that may be functionally important. PHBC is the third enzyme of the poly-beta-hydroxybutyrate biosynthetic pathway.	25.00	25.00	31.30	31.60	21.60	21.30	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.24	0.72	-4.43	58	186	2009-09-24 09:22:42	2009-09-24 10:22:42	3	3	155	0	73	185	19	45.40	41	7.67	CHANGED	ssssshptlD+th+Asl.A+hTuGlSPsulthAahDWuhHLAsSPGK	......s...s.hphlD+thcAsl.A+hTuGLSPAuLshAahDWhhHLAsuPGK...........	0	14	40	58
+12386	PF12552	DUF3741		Protein of unknown function (DUF3741)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length.	21.80	21.80	22.30	35.20	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.17	0.72	-4.24	30	140	2009-09-24 09:27:59	2009-09-24 10:27:59	3	5	19	0	93	127	0	45.00	40	5.10	CHANGED	lppKhh-u..K+Lus...DcphppSKEFh-AL-lLsSNK-LFlKhLQ-Pso	................lppKhh-u..KcLuo...cpphppSKEFt-AL-lLsSN+-LFLKhLQ-Pss...	1	11	52	76
+12387	PF12553	DUF3742		Protein of unknown function (DUF3742)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. There is a single completely conserved residue Y that may be functionally important.	20.90	20.90	21.10	21.00	20.10	19.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.06	0.72	-3.51	20	78	2009-09-24 09:30:26	2009-09-24 10:30:26	3	1	60	0	28	76	3	51.80	29	43.65	CHANGED	LALL.LsFsllAAWhspssss....................DpsEtt...sEaRpG.uGaGLYcss.hRlD	.........................................hALl.lshlslAuWhspsss..............................c.s-...........phRpG.sGaGhYsss.hRlp.........................	0	5	19	26
+12388	PF12554	MOZART1	DUF3743;	Mitotic-spindle organizing gamma-tubulin ring associated	Gavin OL	lg7	Prosite	Family	The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, this family does not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. MOZART1 is required for gamma-TuRC recruitment to centrosomes [1].	19.90	19.30	21.30	24.10	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.04	0.72	-4.50	48	221	2009-09-24 09:35:15	2009-09-24 10:35:15	3	7	188	0	167	215	0	47.20	48	44.27	CHANGED	upcsl-llaclSsLLNT.GLD+csLslslpLlEsG.VsPcALApllpcl+	......c-shDlLaEISplL....NT.uLD+cTLSlClpLhEpG.lNPE.ALA.....sVl+ELR.....	0	49	82	127
+12389	PF12555	TPPK_C		Thiamine pyrophosphokinase C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 50 amino acids in length. The proteins in this family catalyses the pyrophosphorylation of thiamine in yeast and synthesizes thiamine pyrophosphate (TPP), a thiamine coenzyme.	22.70	22.70	24.30	26.70	22.30	22.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.42	0.72	-4.24	50	284	2009-09-24 09:39:24	2009-09-24 10:39:24	3	3	282	0	98	221	0	53.40	32	13.78	CHANGED	+uVupLY+sRlSst.tlhhllLAuLlAlssslhlossu..pshhphlssphpshht	...KuVupLYRs+lSsu.ulhhLlLusLlAlhlslhlosss..tshlphlhspWsphh......	0	44	78	92
+12390	PF12556	CobS_N		Cobaltochelatase CobS subunit N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF07728.  There are two completely conserved residues (P and F) that may be functionally important. This family is the N terminal of the CobS subunit of cobaltochelatase. Cobaltochelatase belongs to the AAA+ superfamily of proteins. CobS and CobT form a chaperone like complex.	21.50	21.50	21.70	23.20	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.10	0.72	-7.70	0.72	-4.52	79	346	2009-09-24 09:46:14	2009-09-24 10:46:14	3	3	337	0	109	304	959	35.70	48	11.07	CHANGED	spshhstPDpplSVR-lFGIDoDhpVPAFoc.ts-+V	.......shsshPDppVSVR-VFGIDoDhpVPAFop.sss+V....	0	28	67	82
+12391	PF12557	Co_AT_N		Cob(I)alamin adenosyltransferase N terminal 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 20 amino acids in length. The family is found in association with Pfam:PF02572. Cob(I)alamin adenosyltransferase adenosylates Co(I) in an ATP-dependent manner in the conversion of aquacobalamin to its coenzyme form. This is the third step in this process, after two steps involved in the reduction of Co(III) to Co(I).	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.64	0.72	-6.66	0.72	-3.98	89	1083	2009-09-24 09:49:35	2009-09-24 10:49:35	3	3	996	1	172	551	72	22.10	48	11.01	CHANGED	tsstcspRHptRMp+hKpshDp+l	...........sERappRQQ+lK-pVDARl...	0	23	74	122
+12392	PF12558	DUF3744		ATP-binding cassette cobalt transporter	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00005.  There is a conserved REP sequence motif. There is a single completely conserved residue P that may be functionally important. The proteins in this family are frequently annotated as ABC Cobalt transporters however there is little accompanying literature to confirm this.	22.50	22.50	22.70	24.00	22.40	18.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.28	0.72	-3.53	55	750	2009-09-24 09:52:23	2009-09-24 10:52:23	3	4	746	0	68	428	1	72.30	36	12.82	CHANGED	poslLpchGlREPLYloALKtuGhslsphpclsslssLshsp.hpttlppWhp.ptshhppppppc.............sLLclcsLoa	......oslLppsGIREPLYlTuL+thGlDlsptcpLusL.cslshsc.h...hppa....psp....scpp.ctp.............sLLcLcpVoa..............................	0	19	34	49
+12393	PF12559	Inhibitor_I10		Serine endopeptidase inhibitors	Coggill P	pcc	MEROPS_I10	Family	This family includes both microviridins and marinostatins. It seems likely that in both cases it is the C-terminus which becomes the active inhibitor after post-translational modifications of the full length, pre-peptide. it is the ester linkages within the key, 12-residue. region that circularise the molecule giving it its inhibitory conformation [1, 2, 3].	20.50	20.50	26.20	22.20	18.00	18.80	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.17	0.72	-3.69	18	45	2009-09-25 12:15:30	2009-09-25 13:15:30	3	2	25	1	16	49	1	49.40	44	91.94	CHANGED	Msps.........p..p.cAl.PFFARFL-pQ..................................t.tstsstpsp.s.h.ThKYPSDhE-s	..................psppsKAl.PFFARFLpspp...............................t.ps.psssscssh.sThKYPSDWE-..	1	2	7	16
+12394	PF12560	DUF3745		Protein of unknown function (DUF3745)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00097, Pfam:PF10426.	21.20	21.20	21.20	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-7.87	0.72	-4.29	99	1647	2009-09-25 12:31:12	2009-09-25 13:31:12	3	7	890	0	1	1687	0	38.20	45	8.84	CHANGED	ANs-KGKsAASLDKVs....DshsLhsQc.PFcpcppLNsuhQo	...ApppptcsAASLDKVsEpp.-ssslhsp..PFcoDp-LNpuhQT......	0	0	0	1
+12395	PF12561	TagA		ToxR activated gene A lipoprotein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF10462. There is a conserved GAG sequence motif. This family is a bacterial lipoprotein.	25.00	25.00	41.50	40.70	18.80	16.70	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.80	0.71	-4.17	9	172	2009-09-25 12:32:18	2009-09-25 13:32:18	3	8	73	0	7	89	0	135.30	45	17.05	CHANGED	a-h.ts.p.th.spGW.passslssppltpsp...WpThplsspp.hlC+Fsa.sssGcptsFVGaV-...sssthCpuuc-hpap.suppp.h.Sp.sDYpLLS.hGc..GpV.oYsPss-lGEssLCoLs+sGss....GAGFlsss	.......F-L.pPcp.EhpLcGW.Qtsssls.tp...h....Nsp......WpTMhls...sppphICRFsYhussGcphpFVGals...tpcplCoGGR-l+ahp.Dtpp..I-SphsDYELLShhGc..GpV.oYsPsspIGEspLCoLspsuss....GAGFl+s.t.	0	3	3	5
+12396	PF12562	DUF3746		Protein of unknown function (DUF3746)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF04595.	21.80	21.80	32.70	37.40	18.20	17.30	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.19	0.72	-7.77	0.72	-4.10	9	53	2009-09-25 12:33:09	2009-09-25 13:33:09	3	1	36	0	0	43	0	36.10	65	9.39	CHANGED	SoFssPpL+ssspsp....sC+KpsFsNSpaTTRTssal	....SSFPVPTIKSVTNKKK...ICKKHCFVNSQYTTRTLSHI	0	0	0	0
+12397	PF12563	Hemolysin_N		Hemolytic toxin N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF07968, Pfam:PF00652. This family is a bacterial virulence factor - hemolysin - which forms pores in erythrocytes and causes them to lyse.	22.50	22.50	25.00	24.50	17.50	17.40	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.08	0.71	-4.86	7	120	2009-09-25 12:33:59	2009-09-25 13:33:59	3	4	81	15	5	93	2	176.30	68	28.55	CHANGED	.KlNpptssh.lslhSulusssshAsIspPsGtAlphhSplpssptlhYhNAu.W.sEcsph.......oLsplR-pVlNQphRhhlDFStIpspspp.sphpsphRpphGluFussFllIoEHKGELLFTPhDss-D.........lsstLLEAsttpRsh..ot.sott...sossETsoLPHVAFYlNVNRsISDpECTFsNS	..........................Kh.ppt.sl.hTILSAlS.SsTlhANINEPSGEAADIISQVADSHAIKYYNAADWQAEDNAL......PSLAELRDLVINQQKRVLVDFSQISDAEGQ.AEMQAQFRKAYGVGFANQFIVITEHKGELLFTPFDpAEE.........VDPpLLEAPRTARLL..uRSGFAS..PAPANSETNTLPHVAFYISVNRAISDEECTFNNS.....	0	1	2	4
+12398	PF12564	TypeIII_RM_meth		Type III restriction/modification enzyme methylation subunit	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF01555.  There are two completely conserved residues (F and S) that may be functionally important. This family is a bacterial phage resistance protein. It functions in a type III restriction/modification enzyme complex. It is part of the methylation subunit of the complex. It binds DNA and methylates it.	25.00	25.00	29.50	29.20	19.80	19.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.66	0.72	-3.99	21	216	2009-09-25 12:35:04	2009-09-25 13:35:04	3	4	186	0	19	219	15	56.10	43	11.50	CHANGED	hDcpLlphLLpspp....lKppFFpcl.sshhlFchpcFlchlc.Kca......Lss..SaT+apNKIGL	......D.pLlshLLps-p....lKcpFFhcl....sssLVFchpcFh.hL-p....+p.......lss..SYT+YsN+IGL..	0	7	10	14
+12399	PF12565	DUF3747		Protein of unknown function (DUF3747)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 215 and 413 amino acids in length. There is a conserved DSNGYS sequence motif.	25.00	25.00	141.80	141.50	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.03	0.71	-5.21	38	86	2009-09-25 12:38:19	2009-09-25 13:38:19	3	4	48	0	36	105	45	180.40	40	57.40	CHANGED	hthhhphsslsshslsshhs..ssupAuh.FspptlsQscalslApP...hG..sspapLLllEQI...pspptCWpEpussPs.lV-PLLLsFD...FTGICsRuoDSNGYSlRhuGpDlGhsYpLRlhppss-LlLh....uhs.t.ssssst.lllGRopGh.s...sG.FlKlpLpPGWchs+RoYpG+sLGHlYhusspsss	............hh.....hsslsshslsuhhs..ssspAuhFspptl-QscalslAtP...hG..sspapLLllEQI...ssp+.CWs-sGusPs.hV-PLLlsFD...FTGICsRusDSNGYSlRlsGpDLGhcYhLpllppsu-LlLl....usspt..ssstsp.lllG+opGhu....sG.FlKlpLpPGWphs+RsYpG+sLGHlYhsssps.s....	0	2	21	32
+12400	PF12566	DUF3748		Protein of unknown function (DUF3748)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 120 amino acids in length.	21.70	21.70	22.00	27.50	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.70	0.71	-4.20	11	511	2009-09-25 12:39:24	2009-09-25 13:39:24	3	7	505	0	47	269	3	117.80	83	28.83	CHANGED	AaVGVVTVSPspP.RYsFIHGPEpPDspWpYDFHHRRGVlVt..psGpApsLDAhDITsPYTsGALRGGSHVHVFSPDGsRLSFTYNDHV..MHEhDsphDhRNVGVAlPhpsVss.sKpHPREY	..........AHVGVVTVHPcuE.....K.YVFIHGPENPDETWHYDFHHRRGVIs...EuG....+VoNLDAMDITAP.YTPGALRGGSHVHVFSPNGERVSFTYNDHV..MH.....EhD..........PA....LDLRNVGVAAPaG......P.VNV....QKQHPREY...................	0	4	15	30
+12401	PF12567	CD45		Leukocyte receptor CD45	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 77 and 1130 amino acids in length. The family is found in association with Pfam:PF00041. CD45 plays a critical role in T-cell receptor (TCR)-mediated signaling. CD45 interacts with SKAP55 which is a transcriptional activator of IL-2.	25.00	25.00	25.60	30.40	24.90	17.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.26	0.72	-4.12	10	83	2009-09-25 12:40:21	2009-09-25 13:40:21	3	19	34	0	13	87	0	60.40	47	7.86	CHANGED	TVDYLYscpTKLFTAKLNVNEsVcCsNs.....sCTNNElpNLsECcp.toVolSHNSCTsPsKpLp	.oVcYhYsppoKhFTAcLNVs.-sVcCsss......sC.sNElpNLsECcp.tsVolSHsSCssPtKpl.....	0	1	1	2
+12402	PF12568	DUF3749		Acetyltransferase (GNAT) domain	Gavin OL, Bateman A	lg7	Prosite	Domain	This domain family is found in bacteria, and is approximately 40 amino acids in length. The proteins in this family are acetyltransferases of the GNAT family.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.53	0.71	-4.54	21	619	2012-10-02 22:59:21	2009-09-25 13:41:38	3	2	602	1	54	719	54	121.30	65	95.94	CHANGED	KLTIppLs....phSsQDhIDLuKIW.........Ppps.ptLpttl......sssppLaAARFN-RLLuAscVplpsp..pupLscLpVREVTRRRGVGhYLl....-EshRph..PplppWhhsttshp..chsshssFhpAsGF..stpsstWp	..........................................................................KLTIlRLE....pFS.c.QD+ID..Lt...K.I..W.................P.EYSsS.SL..p..V........D.-.s.HRI.Y.A..A..R.F..N..E...R.L.....Lu..A.V......R..V......T......L......S......G.....T........p..GA......LDSLRVREVTR.RRGVG....QY....Ll....EEV.....LRsN.....P.s.V..Ss.W.W.M.A.D..sGVE..DRuVMsAFMQALGF..TAQpsGWE.......................................	0	7	19	36
+12403	PF12569	NARP1		NMDA receptor-regulated protein 1 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF07719, Pfam:PF00515. There is a single completely conserved residue L that may be functionally important. NARP1 is the mammalian homologue of a yeast N-terminal acetyltransferase that regulates entry into the G(0) phase of the cell cycle.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	517	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.82	0.70	-5.75	32	545	2012-10-11 20:01:02	2009-09-25 13:43:38	3	42	309	0	357	564	23	365.10	30	57.91	CHANGED	hEaSEhlLYpsplltEuGphEcALc+L..cphpppllD+LAlhEh+uchLlcLGRppEAptsYcsLLcRNP-NhpYYcuL.csh..........t..................hspt...p.pshhslYcphsppa.P+usAs+RlPLcFhp.................G-cFcphs-tYlcphLpKGVPSLFsslKsLYs.cspKhsllp-LlptYhp...shpssuphstps....p.ptcssoshhashYaLAQHYsa....hts.......p-..KAlcaI-pAIppo.Pohl-hahsKARIhKHuGDltcAAchM-cARpLDttDRYINoKsAKYhLRsscsccAtchhuhFTRpts..ushssLp-MQChWa.hEsucuahRpt+hGhALK+apsVp+hFsphhEDQFDFHoYslRKholRAYVchLRaEDpLRsHPaYh+AAtsAlcsYlpLaDpP...hsps.......ph..u.........shsssEcKKhtc...Kt+Ks.pp+tcc-ptct.ttppt....tp..ttttttKttsscsct.Ds...DPhGpKLhpop..-PLc-AhKFLpPL.phuspslEsplhuFEVahR+pKhLLALpslppA	....................................................................................................................................................E.SEhhlYp.s.lh......c.....t.......s.hpp....uLphl.....pp...ttphhDthth.Ehp..u.phhhpLs..ph......p-.AtthaptL..phNs.-s..Yattl.psh............................................thhth...ap...ph..t.h....s...p..s..ss+.h.ls.Lphh.......................s.p.p..F.pphhptal.....h..p+.......G.hPshFssl....+....L........Y.......p.........t........K....h....t..h..lt......plh.th.t...................p..t.pt....................p..ss..hh...s.hhLAQHash......htp..........p..hAhph...lp...tAIt..........s...Ps....h.l...-..hahhKu+IhK......+hGph.pAs.phh-pAptLDhtDRalNsKs.sKYhL+s............s....................p...........cA.phhshF.T+tt...................sshtsL.-hQshWa.hcsutua.t..............................t.p..h.................u.ALK+hht.l.pha..h.-DQaDFHsa.shRKhphRuYlphlchpD.lhtp.hah+us.....h.shph.Yhtlh-...p............ttt................t......................t......p...cch.p....p.ppt.t.p.t...tt........................................................t............p...s.t....l.......t.............t.htt.h...p.hh..h...s......t.............s..h..hc....h..t...tt.h..h.....................................................................................................................................	0	119	195	289
+12404	PF12570	DUF3750		Protein of unknown function (DUF3750)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 175 and 265 amino acids in length.	25.00	25.00	36.40	98.40	19.70	17.50	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.90	0.71	-3.88	33	129	2009-09-25 12:44:47	2009-09-25 13:44:47	3	1	127	0	59	131	32	131.70	45	55.96	CHANGED	tpAlVpVYAA+shuWRGhaAlHoWlls....KtsuuspYsRa-V........lGWGh.....sl+p.sthsPDutWaGutPcllhshcGctAcplIspIcsAlpsYPass..pYcsaPGPNSNTFlAalh+pVPpLplsLPssAIG+DY	...pAlVpVaAApshuWRGhhAVHsWIlh....KctGuspYsRY-V.............luWGt.....slRp.sshsPDuhWaGupPcllsshcGtpApplIPcIcsAlpsYPass..sY+sWPGPNSNTFlAalhRpVP-LplsLPssAlGKDY	0	13	26	39
+12405	PF12571	DUF3751		Phage tail-collar fibre protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is approximately 160 amino acids in length. There are two completely conserved residues (K and W) that may be functionally important. The members are annotated as being putative phage tail or tail-collar proteins.	23.00	23.00	23.10	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.80	0.71	-4.40	47	961	2009-09-25 12:45:44	2009-09-25 13:45:44	3	33	662	0	136	906	8	148.70	39	30.54	CHANGED	M...u.....sllTptGcphlAppsutGpslplsphlhAsssG.....s.hssspshsshsphVacsslsph..uhhNsNtVlhshllssslGsF.ashlGLh..sssusLhulspsPpphKhpstpGs...Gpslscshllpao..sspplTtlplssssW.hshtAch.pshD	..........Ms..cahollTshGts.+l.AsAs.A.h..G.p...l.p.lopMAVGDGsG.............shss..P.s..ssQ...T.t.Llpc.hhRuslNpl.....lDsp.N..s..s.tl...l..A.EhlI.P..p..s......h..G...GFalRElGLa....D-sG..sLIAVuN.s.P.E...o.YK...Pt.ltEGS....G+spThRhllhlS..ssssls.LplDsss....lhATpcYVD.........................................................	0	19	59	98
+12406	PF12572	DUF3752		Protein of unknown function (DUF3752)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 140 and 163 amino acids in length.	22.30	22.30	22.30	22.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.04	0.71	-4.09	41	249	2009-09-25 12:46:56	2009-09-25 13:46:56	3	8	209	0	181	244	1	139.20	25	38.15	CHANGED	PPpppshtuhhsss.....RpFspu....+sut.........ssSsWT-TPt-+tcRhppphhuhpstst..........sttttttpsppstc.......ttlcpYscp.pRucSLlppHpccpppptpp..................................pppsssstRsFD+-+Dhplspp..sptpp+chlp+u.tshusRFus	................................................................................RpFpptt......tttts..............spShWT-TPt-+t+....+hp.pp..uhps.s.....................pttpp.thhpt.pcpc................htpplppascp...pRu.cSLh-hHpcchcppttp.....................................pppss.p....p+s..FDR-+Dlpssph....spsp++pllp+u.pplsoRFup......................	0	62	95	141
+12407	PF12573	OxoDH_E1alpha_N		2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00676.  There are two conserved sequence motifs: VPEP and RPG. This family is the alpha subunit of the E1 component of 2-oxoisovalerate dehydrogenase. This is the enzyme complex responsible for metabolism of pyruvate, 2-oxoglutarate, branched chain 2-oxo acids and acetoin. The E1 component is a heterotetramer of alpha2beta2. The homodimerised beta subunits are flanked by two alpha subunits in a 'vise' structure.	25.00	25.00	28.60	28.20	19.60	18.50	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.06	0.72	-4.41	28	200	2009-09-25 12:48:08	2009-09-25 13:48:08	3	1	198	5	52	156	12	42.80	58	10.39	CHANGED	tssLpLHVPEPssRPG-pPDFSplcIscAGul..RPslsssPt-	...h..sLpLHVPEPssRPGspsDFSal+lstAGsVR.RPsIDspPt.....	0	9	26	39
+12408	PF12574	120_Rick_ant		120 KDa Rickettsia surface antigen	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. This family is a Rickettsia surface antigen of 120 KDa which may be used as an antigen for immune response against the bacterial species.	21.00	21.00	22.70	21.60	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.66	0.70	-5.28	7	128	2009-10-28 17:27:32	2009-09-25 13:49:09	3	1	98	0	11	123	1	227.80	70	29.18	CHANGED	lL+-hhs.hs.-LAEphthc.....-cD++hcsFh....tNsspRphlspAhEssEhKKtLEsIEIsGY+NlhsoaSA........................................................................tstYtGGF+PlQWcNpl.SAusLRuTVlcNDAG-ElCTLsEpThKTpPhhlAKQDGTpVplsSYRpIDFPIcL-c.AsGoMHLShVAhcsDGppPucs+AVYFTAHYEps..PNGpPpLKElSSPpPLKFhGsss-AlAYIEHGGEIYTLsVTRGKYcEMMKEVtlNpGQuVDLSQ..tpDlhcVQGpup	...........................................................ILKDLAALTDRDLAEQKRKEI..EcEKDKTLSsFF....GNPANREFIDKALEsPELKKKLESIEIAGYKNVHsTaSA........................................................................AsGYsGGFKPVQWENpV.SASDLRATVV....KNDAGDELC.TLNETTVKTKPFTlAKQDGTQ.V.QIoSYREIDFPIKLDK.ADGSMHLSMVALKADGTKPSK.DKAVYF..TAHYEEG..PNGKPQLKEISSP.p.P.LKFAGTGDDAlAYIEHGGEIYTLAVTRGKYKEMMKEVcLNpGQSVDLSQ..A...EDlhhsQGtSp...................	0	1	2	2
+12409	PF12575	DUF3753		Protein of unknown function (DUF3753)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in viruses. Proteins in this family are approximately 70 amino acids in length. There is a conserved YLK sequence motif. There are two completely conserved residues (D and F) that may be functionally important.	21.60	21.60	21.60	69.00	21.40	21.00	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.56	0.72	-4.18	14	56	2009-09-25 12:50:08	2009-09-25 13:50:08	3	1	43	0	0	36	0	71.00	54	97.91	CHANGED	MDKLYsulFGVFhoSsD-.DFppFI-lV+SVLoDcps.tp.pss.s..t..hlllsllhlllllll..hFlYLKlh	MDKLYAAIFGVFMuSs.-D...Dhs-FIEIVKSVLSD-Kosss.osssss.ashaaLIIlhhlVlIllLL..laLYLKVV.	0	0	0	0
+12410	PF12576	DUF3754		Protein of unknown function (DUF3754)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.	21.50	21.50	22.50	21.80	19.60	21.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.87	0.71	-4.55	22	186	2009-09-25 12:53:38	2009-09-25 13:53:38	3	4	103	0	108	188	16	150.90	23	30.01	CHANGED	a-clllhh+...........................................hcssph.tt......................................tppphshtssplhl+lFcslPcsDL-hlFPNt+lshphhDplhlslsulhushslllphlht.hlhlsshh.hh........................hhtslhuhssLuuaha+passYKs+ph+apptlscsLaFKsLssNuG	...............................................................................................................................................................................................................................................ttpttslhlKtFKsIPhsDLEhlLPcp..c.lphs.hDtlhlslsslluhlslhsshhthh.......s..............................hhsslhllssh.s.hhsh+th.h..sFppphspap.hhlscsLY.KslssspG.............................	0	31	67	86
+12411	PF12577	PPARgamma_N		PPAR gamma N-terminal region	Gavin OL	lg7	Prosite	Family	Peroxisome proliferator-activated receptors (PPAR) are nuclear hormone receptors that control the expression of genes involved in lipid homeostasis in mammals.  This sequence region is found at the N-terminus of these proteins. The family is found in association with Pfam:PF00104, Pfam:PF00105. It is not clear if this region is a separate protein domain.	25.00	25.00	27.10	26.10	21.70	20.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.07	0.72	-3.67	8	132	2009-09-25 12:56:48	2009-09-25 13:56:48	3	3	66	0	30	125	0	83.90	64	18.98	CHANGED	MVDT.QhhuWP.VGFGLSulDLsEL-DcSHSLDlKPFoTlDYoSISS...................hcY-ssPsps-.hs+sMDhophYuYch.....................................+hppsQsSIKL	..MVDT.EMPFWP.sNFGISSVDLSsMDDHSHSFDIKPFTTVDFSSISo...................PHYEDIP.........FsRsDPhVsDYKYDL.....................................KLQ....EYQSAIKV.......................................................................................................................................................	0	1	3	10
+12412	PF12578	3-PAP		Myotubularin-associated protein	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 115 and 138 amino acids in length. Myotubularin is a dual-specific phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bisphosphate. 3-PAP is a catalytically inactive member of the myotubularin gene family, which coprecipitates lipid phosphatidylinositol 3-phosphate-3-phosphatase activity from lysates of human platelets.	20.40	20.40	20.50	20.60	20.30	20.20	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.57	0.71	-4.33	21	204	2009-09-25 12:59:09	2009-09-25 13:59:09	3	9	92	0	111	195	0	124.90	25	18.37	CHANGED	p.pth....s.........hcslssttpph.tss..hht.h.ph....ssspsp.tstspph.ts..ths.......p.pphLpPtptshplplWsQCYhRWhPhtplpsGG.spl.hphphhhsc..l...pclpchlcppchtplsssphc	........................................................................................hP.s.p....tpt.hh..pp.h.hp.......sp......p..sp.tss.cphhcphauhP............ss..cGlLLPt...........hpGscl+lWppCY.LRWlPEsQI.ttGG.sts..p.lp.Lh-E.....l....ppLpctlcptp.t........t...................................	0	19	30	63
+12413	PF12579	DUF3755		Protein of unknown function (DUF3755)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a single completely conserved residue N that may be functionally important.	25.00	25.00	27.80	27.10	24.90	23.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.40	0.72	-4.56	27	109	2009-09-25 13:00:09	2009-09-25 14:00:09	3	2	21	0	64	100	0	34.90	40	12.41	CHANGED	ushp.lp-NlsLhppsRcNIhslLpchs...phPslMsp	.....shp.hp-NlsLFp+sRcNIpslLsc.Ms...phPGIMsp........	0	11	34	49
+12414	PF12580	TPPII		Tripeptidyl peptidase II 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.	25.00	25.00	29.30	28.20	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.14	0.71	-4.99	24	162	2009-09-25 13:02:15	2009-09-25 14:02:15	3	9	122	1	112	157	4	190.60	42	15.09	CHANGED	l-lp.u.LtsEclpPslsLcphthsh+Psp.uKIpPLu.sRDllP.sG+QlaplhLTYphp.........................ls.cuuEVssphPhlschLYEucFESQhaMlFDsNKphlusGDuYsp................................hKL-KG-YTl+LQlRH-ppplLEKlK-hslhlppKL.s.s.lsLclasshssslsG..stcassttltsGpspshYl.sslss-KLPKsshPG	.........csp.osLphE-.lsPsloLKs............hspsLRPsp.uK....lpPL...............u..sRDl.LP..ssRQlYp............hl.....LTYsF+..........................s.KuuEV.sPpsPlLs...-hLYESEF-SQhWhlFD.p.NKphhusGDAYPc.............................pas.h.KL-.KG....-.YTlRLQlRHEphshLE+L.K-l..shllsc+L..u.ssloLDlapshs..............tAlhG......ppKh..s.shsLsPt............hspshal.ssl.s.cD.KlPKsssP.......................	0	42	59	89
+12415	PF12581	DUF3756		Protein of unknown function (DUF3756)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 40 amino acids in length.	25.00	25.00	36.30	34.80	17.80	16.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-7.98	0.72	-4.27	18	76	2009-09-25 13:03:18	2009-09-25 14:03:18	3	4	5	0	0	68	0	40.50	88	2.91	CHANGED	lASGYRTN..ALVAPQAKISIGAYAAEWALSTEPPPAGYAIVR	.LASGYRTN..ALVAPQAKISIGAYAAEWALSTEPPPAGYAIVR	0	0	0	0
+12416	PF12582	DUF3757		Protein of unknown function (DUF3757)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 154 amino acids in length.	21.10	21.10	25.60	24.40	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.02	0.71	-3.92	25	155	2009-09-25 13:04:14	2009-09-25 14:04:14	3	2	95	0	19	82	0	109.00	29	78.44	CHANGED	sspsCPulssI.pts........GsYoA..ssssscWhGs..pG.hsptp..lppFppAhhl.tss.t.....t.Gph.pCoYpl.spstplDhhap......spshhholps.pst....Wcpppssh...h.hh.Co..sssscpCpFc	.........t..ppCPshstIp..t......GsYsu....sstpWhG...pss.spts..lppF..Ahhlstst.......s.sth.pCTYtl..tstplDhhat....................hspshhholhs.psh....Wctppssh...hp.hhCo..ssusppCpFs.....	0	2	7	12
+12417	PF12583	TPPII_N		Tripeptidyl peptidase II N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. The family is found in association with Pfam:PF00082. Tripeptidyl peptidase II (TPPII) is a crucial component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It is an amino peptidase belonging to the subtilase family removing tripeptides from the free N terminus of oligopeptides.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.97	0.71	-4.04	7	69	2009-09-25 13:04:59	2009-09-25 14:04:59	3	7	30	1	23	76	0	126.70	54	20.09	CHANGED	sGuuNsuususuTsAAAA.AsTssusKPKssus..ttsuh..sssAuGDGVssQo-sPsps.sssPuSPKKGKosuD-YuEuLRDFQCoaIsKs-hEhAEKIYp-VltAHPKHLtAHLhLIQNIESspLK.spLPLsFssupcsp	...........................P.PAKKoSSTANATTGAAs.AlTNsATNGN.VANA........GSNGT....GNNVITATNGAA..NGSlPNGTAVK.ENRSKW.DEYCEGLRDYQTAQISKLDA.ENA....ENVYQALLKDNPNHLA...AHLAMADHFDS.TDLK.Q..NLPYTFTAShD.u.......	0	9	12	21
+12418	PF12584	TRAPPC10	DUF3758;	Trafficking protein particle complex subunit 10, TRAPPC10	Gavin OL	lg7	Prosite	Family	This domain forms part of the TRAPP complex for mediating vesicle docking and fusion in the Golgi apparatus. The fungal version is referred to as Trs130, and an alternative vertebrate alias is TMEM1 [1,2].	21.60	21.60	21.60	21.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.90	0.71	-4.70	32	265	2012-10-04 00:47:01	2009-09-25 14:07:17	3	10	233	0	196	280	1	163.40	21	14.07	CHANGED	slslPslphlhsssht.hppssh........................................................................tVGp.lshplplcp.pphWss.t.t..............................p.sh....chhYcl..sss-sWhluG+++Gphph.................ppssphp......hslhllPLtsGaL.hPplplpshs...........................................................tt..sscl..psuuppllVl	........................................................................................................................................h.hP.lphhasspht....p.tt............................................................................hspsGphhshplplpp.sp.hpst.....................................tttst.......chhYEl...hsssssWhlsG+p.pGshsh................................tpssptp............lslhllPLpsGaL.shPslclhphh..............................................................t...ssps..pshu.plhV.........................................	0	49	96	159
+12419	PF12585	DUF3759		Protein of unknown function (DUF3759)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 107 and 132 amino acids in length. There is a single completely conserved residue H that may be functionally important.	25.00	25.00	49.70	48.60	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.07	0.72	-4.08	39	128	2009-09-25 13:08:28	2009-09-25 14:08:28	3	3	85	0	89	132	0	92.90	46	72.33	CHANGED	psacpVh..st........pHcu+hSHELlAGAAuFEAhKsaE-+pc+....................pGKPsSHAhAKElLAGhAGAtlD+lhET.KGLD...alD+-cAK+cAccpscchhcpcY	..............t.tapplh..st......pHcu+hSHELlAGAAuFEAhKAaE-Hpc+....................pGK..PsSHAhAKElLAGhAGAtlD+llET.KGLD...alD..+-+AK+cAccpAcchhsppY.................	0	33	54	76
+12420	PF12586	DUF3760		Protein of unknown function (DUF3760)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 46 and 64 amino acids in length.	25.00	25.00	26.80	25.40	23.90	20.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.36	0.72	-8.25	0.72	-4.12	15	44	2009-09-25 13:09:30	2009-09-25 14:09:30	3	2	3	0	13	37	0	51.60	31	15.26	CHANGED	oL.................sPL.ssVpclIh-cLutlsP..lphLplS...........................................+haY.....................+cllPplY+sVsls	....................LssL.tsVpclIh-pLstlsP..lphlplS...........................................+haY.....................+chlPhlY+pVsl..	0	13	13	13
+12421	PF12587	DUF3761		Protein of unknown function (DUF3761)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 157 amino acids in length.	22.00	22.00	22.10	22.00	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.51	0.72	-3.87	9	145	2009-09-25 13:10:56	2009-09-25 14:10:56	3	3	109	0	45	146	5	71.50	43	53.39	CHANGED	+tsslsuuLhAshhhhshsAaAhs.............stusLspcspYhN+DGtsVHuPA+sh..psPsGATA+C+DGoYSFSpH++GTCSGHGGVspWh	..............................................................................................t............................................................hpAPA.....p....s.P.sGs.T....A.....hC+DGoaShutp..+.+GsCSGHGGVssWh...	0	8	21	32
+12422	PF12588	PSDC		Phophatidylserine decarboxylase 	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF02666. Phosphatidylserine decarboxylase (PSD) is an important enzyme in the synthesis of phosphatidylethanolamine in both prokaryotes and eukaryotes.	23.40	23.40	23.40	23.60	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.88	0.71	-4.57	45	205	2009-09-25 13:12:22	2009-09-25 14:12:22	3	6	143	0	118	199	5	133.40	35	31.88	CHANGED	LtPslp-hpcLI.......EscstlhhLhspMFpp.........tsssGp..plcsacchLpllNtllspAPpass...........suLlGhPlNAlLDWPMuTsuGashFhcPplNtpLK+lLstWupFLsoPcSs..pVLsss.pt........GWFussAhpphpp	..............tsslp-hppLl.......EssshlhMhhspMhc-...............tsssG.p...t..lcsapchLpllstlh.T.p.APpasp...........sGLlGhPlNAlLDW.................PMsTsuGauhFhcspVNtplKclLshW..s.p.FLp....oPcSt..tsLsss..s........GWhuspAhpph..t...........	0	34	64	91
+12423	PF12589	WBS_methylT		Methyltransferase involved in Williams-Beuren syndrome	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with Pfam:PF08241. This family is made up of S-adenosylmethionine-dependent methyltransferases [1]. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype [2].	21.00	21.00	26.60	25.20	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.29	0.72	-3.50	79	336	2009-09-25 13:14:03	2009-09-25 14:14:03	3	6	300	0	234	315	1	79.90	30	28.36	CHANGED	LhsG...sh.pt.spsts..p..................t.pph.httpp.pttpppct+th.cp.....u.K-WIh+KKEphR++..G+.cVtsDSKYTGRKR+s+	......................................................G.........sth.s..........................p.pph.t.hs.t.pct.ptp.+pt.c.tcth.cp......................o.+sWIlcKKEphRRp..G+.cV+s..DSKYTGRKR+s....	0	82	131	194
+12424	PF12590	Acyl-thio_N		Acyl-ATP thioesterase	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is typically between 120 and 131 amino acids in length. The family is found in association with Pfam:PF01643. The plant acyl-acyl carrier protein (ACP) thioesterases (TEs) have roles in fatty acid synthesis.	22.00	22.00	50.00	47.30	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.99	0.71	-3.68	24	113	2009-09-25 13:15:00	2009-09-25 14:15:00	3	2	47	0	24	123	0	119.70	58	29.72	CHANGED	M.VAouAuSAFFPVs.Sssssusu..........t.....GphssSLs..GlKuKss.souuhQVKANA....pAsPKlNGopVuhpss.cshcp-s...sss...SssPRTFlNQLPDWSMLLAAITTIFLAAEKQWhMLDWKP+R..PDMLlD	....MsAo..sAs.SuFFPls.osussssu.............tp...hGphssolshtGltuKss..ssGuhQVKAsA....QAsPKlNGopVslhss..phpp-c...sss...ussPRTFlNQLPDWSMLLAAITTIFLAAEKQWhMLDWKP+R..PDMLlD.........	0	1	12	19
+12425	PF12591	DUF3762		Protein of unknown function (DUF3762)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF05533.	21.90	21.90	22.20	51.60	21.50	17.00	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.61	0.72	-3.95	2	72	2009-09-25 13:15:54	2009-09-25 14:15:54	3	3	1	0	0	63	0	78.90	86	6.53	CHANGED	.PSMVAIPVPIuFGshssTAWCS.uDAAVLRCRLsYHAAETsFpspcKHVRYVYNDVSSAANRPRTVSsRKCGpVFPStS	..PPSMVAIPVPISFGshPTTAWCS.A.DAAVLRCRLDYHAAETSFRNE.GKHVRYVYNDVSSAANRPRTVSPRKCGRlFPSGS....	0	0	0	0
+12426	PF12592	DUF3763		Protein of unknown function (DUF3763)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF07728. There is a single completely conserved residue F that may be functionally important.	21.80	21.80	21.80	23.50	21.40	20.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.56	0.72	-4.34	26	649	2009-09-25 13:17:07	2009-09-25 14:17:07	3	2	645	1	56	296	0	56.90	57	11.46	CHANGED	tssphhppLschcpcl+cpRp.......tFpppQPplFIsschLstIEuSLhplscplcphppp	...........h.PuEIKQQLEcLEsDWR+QHs.......hFSEQQ+CLFIsuDWLGRIEASLQDVGtQIRQAQQC...	0	3	14	34
+12427	PF12593	McyA_C		Microcystin synthetase C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF08242, Pfam:PF00501. There is a conserved YAN sequence motif. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases. This family is made up of the C terminal of microcystin synthetase, one of the proteins involved in this synthesis pathway.	25.00	25.00	53.30	52.40	17.40	16.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.02	0.72	-4.20	4	77	2009-09-25 13:18:40	2009-09-25 14:18:40	3	12	60	0	1	68	0	39.10	66	5.19	CHANGED	DVIFspcQspt..+hsLpsFTsTp.Qt....DWQhYANpPLQP+L	DVIFs.hpsp...+tshhsFTPTH.pAKP..-WQhYANHPLps+L	0	0	1	1
+12428	PF12594	DUF3764		Protein of unknown function (DUF3764)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 89 and 101 amino acids in length.	25.10	25.10	25.20	29.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.71	0.72	-4.25	25	55	2009-09-25 13:20:22	2009-09-25 14:20:22	3	1	33	0	17	59	799	83.20	36	88.41	CHANGED	hpToVhTFclossFsEWsthaDupc.pthpcphGIpsLYRGVSc-DPpKlhVlhQA.E.GshppFhpssp..-hIcuuGHlh-oT.hos	.....EToVhsFclossF-EWtthaDup-.pthacphGlpsLaRGhSp-DPp+lhVlhQus-.Gshpphhpssp..chlpuuGHlh-oThho.h..	0	1	7	13
+12429	PF12595	Rhomboid_SP		Rhomboid serine protease	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 210 amino acids in length. The family is found in association with Pfam:PF01694. Rhomboid is a seven-transmembrane spanning protein that resides in the Golgi and acts as a serine protease to cleave Spitz.	25.00	25.00	61.90	56.20	22.80	22.00	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.56	0.70	-4.73	31	130	2009-09-25 13:20:38	2009-09-25 14:20:38	3	5	50	0	58	113	0	199.70	59	25.43	CHANGED	VSKDs-ST.Q+WQRKSlRHCStRYG+LKsQVhREL-LPSQDNlSLsSTETPPPLYlsspp.....hGMQKIlDPLA...RGRAFRhs--.sD..G.SsPHT......PlTPGAASLCSFoSSRSGasRLPRRRKRESVA+MSFRAAAALlKGRSlhDuThpRsp..RRSFsPASFLEEDosDFsD-LDTSFFuR-shhp..EEhSohPD-VFESPu-uAhKphtps..s-pssLTGuALD.....+	.......VScD.-up.Q+WQR....KSl+HCS.RYGKLKsps.REL-LPSQ-ssShpuTEoPsPhhls................KIlDPLA...RGRAFRhsD-.sD.....t.psP...Hs..............PlTPGshSLsSFoSsRSGas+LP.RRKRpSVA+MSF+AAAALlK..GRS..Vh-..u..T.h.pRsp...+RSFs.sSFlEEDsVDhsDphDoSFF..u.......+..hh......EEhSohPD-VFESPs.uA.h.hths...sp.ss.sGstl..................	0	3	7	21
+12430	PF12596	Tnp_P_element_C	87kDa_TransP;	87kDa Transposase	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 78 and 110 amino acids in length. The family is found in association with Pfam:PF05485. There are two completely conserved residues (D and G) that may be functionally important. This family is an 87kDa transposase protein which catalyses both the precise and imprecise excision of a nonautonomous P transposable element.	22.60	22.60	23.10	22.60	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.77	0.72	-3.71	11	61	2009-09-25 13:22:20	2009-09-25 14:22:20	3	3	21	0	20	62	0	83.40	39	15.90	CHANGED	ssscpspp-pals....oopp.cspspppp.........lph.................t.s-Esps.......th.ss.ss.h-hsE....pcDulEYlsGYlh+Kh+.......Lu-hsppsso	...........................................................NltpDNs-sWLN.hs...o.psppcsc.sp.......................................shscEs.-..........phhsNl-h.h-hDE.........LTEDAhEYlAGYVl+KLR.......luspsppp..hs...............	0	3	3	20
+12431	PF12597	DUF3767		Protein of unknown function (DUF3767)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 199 amino acids in length.	25.00	25.00	30.40	26.90	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.54	0.71	-4.43	31	226	2009-09-25 13:23:46	2009-09-25 14:23:46	3	2	207	0	158	219	0	110.60	25	72.96	CHANGED	Psc.ss.....................sps.......tt.pc..olp-Ahcols.hsDF..tphhphPChR-uhlsGhuuhhslGulphlhtt..shhpA.sNWuVGuFhLuulsuaE.CphpRcpphpthppAhchhtc+ctcphccp.pp	........................................................................hpthp.h..sh...hsltphPChR-uhLhGhuuuhshGslpFlhsu..phtpu.ssauVGuFhlsolusW.hCphp...ptppp.thp.shchhtph..........t.............................	0	46	80	124
+12432	PF12598	TBX		T-box transcription factor	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 77 and 89 amino acids in length. The family is found in association with Pfam:PF00907. There are two completely conserved residues (S and P) that may be functionally important. T-box genes encode transcription factors involved in morphogenesis and organogenesis of vertebrates and invertebrates	20.10	20.10	20.60	25.40	19.10	20.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.30	0.72	-3.61	15	119	2009-09-25 13:25:01	2009-09-25 14:25:01	3	2	42	0	52	109	0	84.90	42	13.25	CHANGED	RhYEEppK.t+-susSDcSSuEtssh+..cpss..SPsuussush+l+c.............sS+D-+.tsssss........schpsss--csspssSPutpt	........RlYEE+.pK..+-susSDtSSsE.ssh+..spss..SPh.s.ussus.pL+c..................ps+-E+.stusss........sc.pppopEcsstshu.....s...................................................................	1	2	7	20
+12433	PF12599	DUF3768		Protein of unknown function (DUF3768)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 108 and 129 amino acids in length. There are two conserved sequence motifs: NDP and RVLT.	25.00	25.00	37.60	37.60	18.80	18.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.91	0.72	-4.07	41	95	2009-09-25 13:25:45	2009-09-25 14:25:45	3	1	59	0	32	104	44	83.50	41	66.99	CHANGED	hhTpGltuL........upp.h.....tpllptVpsFDsFss-NDPaGEHDFGsl................chtGppl..aWKIDYY..DhshpauSsDPuDsslTtRVLTlMLAsE	........................hTtGltuL........utth.........tpllctVtsF-sFss-NDPaGEHDFGsl................ch....pGppl..aWKIDhY..Dhsh.....paGSs-PuDsshTtRVLTlMLAsE.......	0	9	26	29
+12434	PF12600	DUF3769		Protein of unknown function (DUF3769)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 560 and 931 amino acids in length.	20.50	20.50	20.60	20.90	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	452	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.44	0.70	-5.67	39	99	2009-09-25 13:26:29	2009-09-25 14:26:29	3	5	90	0	50	103	251	383.70	26	53.78	CHANGED	tssGplsRhRFpAs+lphsscG.WcApchphTNDPFoPsplclcAcssphpp.ss..sc..lpsppsRLll-p+lslP..l.pcphl..pcp...c-.......shhshGaDscDRs....GhFltRshsslp.ssshpLplpPQahlQRAlpsts.s............sppsssh..s-hFGLpucLsuphs..shphpspuslooh.sh-c.hpsshRhpsclppsls..h.sshphsh.hsYRpRlaNGSLG.psV.uuhGuhl............p.................sssh...sssulphsYp......huhthsshps-ph...........psss..........hssLhRhphhuSLspsasLWpGc.shs.TsppuhR.YoPtPllPhlsl.....sTslsushuhYu...sGss.QsoLshosG.phplGpFS+sahDYTthslshutslpsGt.SPFhFDRhlDhtsLshGloQQIYGPlhlustsulNlDs.....GchlsophtLcapRRoYslslhYNPhpplGulphRlsDFN	.................................................................................................................................................................................................................................................................s..stlpphRhputplph.sps.WpupphthoNDPasPsphclputps.h.t.ss...c..l..ptspllh-pthshP..h..pp.h..ppp.p........h.hGhDst-+s....Ghaltpthp.lp.stsh.hplpPQhhlQ+uh...............................tt.tsh..sshaGl.schpsphs..phphp.psp.lssh.s.sp.htst..Rhphphppp...........hs............hphph.hs.YR.RhaNGoLG.psl.puhGshlt.................p......t.sshthsa.......htht.hphps-p......................pspphhshhRhphhsolspth.lWpup.shs.ssppuh+.YoshslhPhltl.....................ssslpushuhYs...sGpp..Qss....ltuolGhshQhGpFo+sahDYTt....hs........ls........h..........utshh........s.....Gs.S........P....F.hFD+hsD.......ht.........s.......L.......shulsQQlhGPlhhssposlslDs..........sp.hsop.h.lpap+...R...oYtlhhhYsPh.phGuhphRls-Fp...........................................	0	11	33	45
+12435	PF12601	Rubi_NSP_C		Rubivirus non-structural protein	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF05407. The rubella virus (RUB) nonstructural (NS) protein (NSP) ORF encodes a protease that cleaves the NSP precursor (240 kDa) at a single site to produce two products.	21.60	21.60	80.10	80.10	20.80	17.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.19	0.72	-4.08	3	69	2009-09-25 13:27:13	2009-09-25 14:27:13	3	2	10	0	0	72	0	55.10	100	3.83	CHANGED	VCAVGGGPRRVSDRPHLWLAVPLSRGGGTCAATDEGLAQAYYDDLEVRRLGDDAMARAALASVQRP	VCAVGGGPRRVSDRPHLWLAVPLSRGGGTCAATDEGLAQAYYDDLEVRRLGDDAMARAALAuVQRP	0	0	0	0
+12436	PF12602	FinO_N		Fertility inhibition protein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 62 and 102 amino acids in length. The family is found in association with Pfam:PF04352. The FinOP (fertility inhibition) system of F-like plasmids consists of an antisense RNA (FinP) and a 22 kDa protein (FinO) which act in concert to prevent the translation of TraJ, the positive regulator of the transfer operon.	25.00	25.00	49.70	48.80	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.57	0.72	-3.68	3	274	2009-09-25 13:28:13	2009-09-25 14:28:13	3	2	214	1	3	135	1	61.60	89	33.64	CHANGED	MTEQKRPVLTLKRKst.EGTAPVcuo....suPGhVpRKKlVVVoTPPAWKVKKQ.........KLsEKAARcAE.................AAARKAAPcP	..MTEQKRPVLTLKRKT..EGETPVRS............RKTIINVTTPPKWKVKKQ.........KLAEKAAREAE.................LAAKKAQARQ.............	0	0	0	2
+12437	PF12603	DUF3770		Protein of unknown function (DUF3770)	Gavin OL	lg7	Prosite	Family	This domain family is found in viruses, and is approximately 250 amino acids in length. The family is found in association with Pfam:PF04196.	21.50	21.50	21.90	66.60	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.53	0.70	-5.26	6	138	2009-09-25 13:29:41	2009-09-25 14:29:41	3	2	49	0	0	162	0	244.00	40	10.83	CHANGED	ss--scEllaRaRLARslh.EL..+pl.Pth.cuDEsls+ppRElpuh.hpuIpI...DWplTEuKF.sPFo+chF-+Fss..hpsDp-Ylu+Ilpcssccuhccl-+spahs-slspptRh-+NuEpuhstlppKhsphpuapphc-hpc..HKSTVQhPshls+....sussspsLpsLpsls....spGsHPhpclWcp.lsssss.lpcIERh+-Ds.hELchAhuuloc+s.E.....RNKYHRssLshs.--+lYlAhlGVs	.....ssEAEEllYRaRlAhplhscL..R........ssDpELsKoEcELLAh.lpuIph......NhshsEusF.PPho+EMa-+FhS..oPsDs-YIT+llStp.lpop-cLhsspahtcssstthRhp+Nu-Es..thpcsLpphput.c.s.+shss..pKuTlQLPPWLsh....hss-upDlsshpGh-....shtDH.PhspLWcc.slssss...LppIEchH.sDsAtEL-hAlSsst.-+s-E.....Rs+Y+Rs+LshuSc-plYhAthGVs..	0	0	0	0
+12438	PF12604	gp37_C		Tail fiber protein gp37 C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and viruses, and is typically between 49 and 166 amino acids in length. The family is found in association with Pfam:PF03906. In T-even phages, gp37 and gp38 are components of the tail fiber that are critical for phage-host interaction.	21.70	21.70	21.80	22.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.86	0.71	-4.42	9	109	2009-09-25 13:31:37	2009-09-25 14:31:37	3	18	66	6	4	116	1	139.60	26	22.38	CHANGED	tssh.s.lp.......lpss.th.......pus.pt..a....cssstpthalu.tGussssDsoh..........hpss.h.hsc..h.sts....sGshpsscWt...ppWLsspL.p.....t.hh............................................hhs..th.t.sshs.hph...us.....sushhlsshuGhh	.........................................................sthsGphplpsspsh......hpuusstutalhu.+ssstssWYlGpGussssDhs.Fashh.h..so.tlt.........lpp..shhshN.c.htlGtAh.ltssGsI.Gohht...staLsshlps......t.h.................................................................................................................................................................................................................................	0	0	2	2
+12439	PF12605	CK1gamma_C		Casein kinase 1 gamma C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 54 and 99 amino acids in length. The family is found in association with Pfam:PF00069. CK1gamma is a membrane-bound member of the CK1 family. Gain-of-function and loss-of-function experiments show that CK1gamma is both necessary and sufficient to transduce LRP6 signalling in vertebrates and Drosophila cells.	21.20	21.20	21.40	21.30	20.40	20.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.22	0.72	-3.42	17	249	2009-09-25 13:32:50	2009-09-25 14:32:50	3	3	74	6	101	230	0	69.50	50	17.15	CHANGED	+...............hsTPsGshps...-sssos......sR-pp.hhpp.....................t..ppN...............................................t.QsloSTNG-LN.sDDPTuGHSNsPI	...................................hsTPVGulp....-sshSs......sR-tHthps+..............................pN...........................................t.t.............sps.QVV.SSTNGELN.sDDPTAGHSNAPI.....................	0	15	25	51
+12440	PF12606	RELT		Tumour necrosis factor receptor superfamily member 19	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 49 and 288 amino acids in length.  There are two completely conserved residues (K and Y) that may be functionally important. The members of tumor necrosis factor receptor (TNFR) superfamily have been designated as the "guardians of the immune system" due to their roles in immune cell proliferation, differentiation, activation, and death (apoptosis). The messenger RNA of RELT is especially abundant in hematologic tissues such as spleen, lymph node, and peripheral blood leukocytes as well as in leukemias and lymphomas. RELT is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1.	28.90	28.90	29.30	29.20	28.70	28.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.41	0.72	-4.82	17	207	2009-09-25 13:33:46	2009-09-25 14:33:46	3	1	110	0	84	175	0	48.90	35	22.33	CHANGED	YhhhllVslFhlhGLLGlhICplLKpKGY+Cos-s.-sp..pccppttc......p	.....hhhhllVslFhlhGLLGlhIC...plLK+KGY+Cos-c.Esps.tstp......p.................	0	6	17	30
+12441	PF12607	DUF3772		Protein of unknown function (DUF3772)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00924.	25.00	25.00	28.20	26.80	23.60	22.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.85	0.72	-4.33	69	289	2009-09-25 13:35:58	2009-09-25 14:35:58	3	3	288	0	87	297	69	63.60	29	7.86	CHANGED	phActhhscAssLhspIsplhRsphsppLhpRusSPLsPshWssshpshspshpplts.ssphh	............ppApthttpApsLsspIsplRRshhpspLstRusS.LuPsFWsslhpshscDhp+Lpshtsp..h.......	0	12	37	61
+12442	PF12608	DUF3773		Protein of unknown function (DUF3773)	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are approximately 110 amino acids in length.	19.90	19.90	19.90	26.00	18.70	17.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.27	0.72	-3.95	5	53	2009-09-25 13:37:22	2009-09-25 14:37:22	3	1	51	0	6	43	6	101.50	63	75.38	CHANGED	h-l++plchlAcshsAcF.................sLcuRploYDEV.FSDTGLLPA...........LsRRADQLsS.LCLGYGlGsoa--AEsALLGV+ssFDEsTP-uLRLhChhDVlsELMpuusuh	..........t.DIpKsMuhIAAuhNAKF.................YLNDRFVSa-EV.FSDTGLLPA...........IA+RADQLCS.LCLGYGLGATaDEAEsALLGlRVVFDEVTPNsLRLLCMTDVlNELIQGGPS.R..	2	3	4	6
+12443	PF12609	DUF3774		Wound-induced protein	Gavin OL	lg7	Prosite	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 81 and 97 amino acids in length. The proteins in the family are often annotated as wound-induced proteins however there is little accompanying literature to confirm this.	27.30	27.30	32.80	31.10	21.70	21.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.91	0.72	-3.13	44	190	2009-09-25 13:38:21	2009-09-25 14:38:21	3	2	24	0	125	175	0	75.20	42	81.28	CHANGED	lAuSluAVEu..lKDQ...thsRWs.shR.Slpppucsph.tshststt....tsutt............sssttspptcpsEESLRpVMYLS.CWGP	................................VAhSlGAVEA..LKDQh...GlCRW.NaALR.SlpppA+s...ss....tu.h....upup+.....hsuus...............ussspcc+tcpuEEuLRsVMYLS.CWGP..........	0	6	76	103
+12444	PF12610	SOCS		Suppressor of cytokine signalling	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF07525, Pfam:PF00017. The suppressors of cytokine signaling (SOCS) family play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms.	20.60	20.60	20.70	20.60	19.60	17.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-9.06	0.72	-3.64	17	118	2009-09-25 13:39:11	2009-09-25 14:39:11	3	5	41	0	58	93	0	55.20	45	12.19	CHANGED	pspsstp.......+p-Rppussultshstthp.....pt.st+uhusRSLRQ+lQDAVGpChPl+oppppp	.......................scssLp.......ppER+ausSSl.....th......Dpssu+phsuRSLRQ+LQDsVG.CFPl+spupp.........	0	5	12	25
+12445	PF12611	DUF3766		Protein of unknown function (DUF3766)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 20 amino acids in length. There is a conserved FTNID sequence motif. There is a single completely conserved residue T that may be functionally important.	21.10	21.10	21.90	21.10	19.00	20.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.42	0.72	-6.76	0.72	-4.42	43	199	2009-09-25 13:40:01	2009-09-25 14:40:01	3	1	191	0	76	173	5	23.90	55	18.69	CHANGED	TVITAhDppphc.sNVFTNIDSAVl	.TVlTAhDppphK.-NlFTNIDuAVI...	1	40	68	73
+12446	PF12612	TFCD_C		Tubulin folding cofactor D C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 182 and 199 amino acids in length. The family is found in association with Pfam:PF02985. There is a single completely conserved residue R that may be functionally important. Tubulin folding cofactor D does not co-polymerise with microtubules either in vivo or in vitro, but instead modulates microtubule dynamics by sequestering beta-tubulin from GTP-bound alphabeta-heterodimers in microtubules.	21.70	21.70	21.80	23.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.23	0.71	-4.88	48	307	2009-09-25 13:41:32	2009-09-25 14:41:32	3	9	222	0	228	309	4	174.30	25	17.26	CHANGED	ssphsppllsslh+QusEKlD+lRtpAspsLpplh.ptst.........................................t.Lpchhs.pp.t.............................................assssphF...splh.pL..Lsls......................happs...............llpGLssSsGu.hoE.ulh+suppALlpalpt........pppppthttlhssllpllp......cptps-Rlsl.PhlchlshLLss.thht.h..pp.t....hhppLhphlppphhp...op.....sht+	.........................................p....hpplhsslhp.usEKlD+hRttAtpshhpll.ptp.s................................h..........l..th.........ttLpp.lhs.stht...............................................asssppsF.stlh.pL...Lt.l..s........................sYpht................lltGLlsSlGu..loE.Sll+top.tuLhpahp............................ppp.pthtthspsllplhp...................pph.ts..-R.......lhl...PhlchlshLlss.shhp.........h.t.t.............h.plhthhppthht...ttsh........................................................	1	108	145	192
+12447	PF12613	FliC_SP		Flagellin structural protein	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF00669, Pfam:PF00700. This family is the bacterial flagellin structural protein. It is involved with cell motility.	25.00	25.00	61.00	61.00	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.70	0.72	-3.75	9	66	2009-09-25 14:21:04	2009-09-25 15:21:04	3	3	42	0	11	43	1	57.00	69	15.32	CHANGED	suTuGTGTAVs.........................sLoLsouAT....uuhoAAptoAhsNulAQINAVNpPsTVSsLDIST	.u.oTAGTGTAso......................TLuLSToAT....SuLSAsDQAsATAMVAQINAVNKPQTVSNLDIST.	0	1	2	8
+12448	PF12614	RRF_GI		Ribosome recycling factor 	Gavin OL	lg7	Prosite	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 130 amino acids in length. There are two conserved sequence motifs: LPS and LKR. Overproduction of ribosome recycling factor (RRF) reduces tna operon expression and increases the rate of cleavage of TnaC-tRNA(2)(Pro), relieving the growth inhibition associated with plasmid-mediated tnaC overexpression.	24.70	24.70	24.90	38.00	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.76	0.71	-4.33	21	130	2009-09-25 14:24:29	2009-09-25 15:24:29	3	1	128	0	22	78	3	124.00	55	96.85	CHANGED	hcpsIoIsLPSLIHRIGp-ssKpApslAtphsC-LKRVRRSRNWplsGcAhplQuFtppL+sp..............pspphpaLIpKl-suLhpHuDKLEPLpsKLhRLlppNPsITLAELMptTpCTlsEARsARFsu-s	.............p.cpsIsIoLPSLIHRIGu-sVK+hKh.AppacCELKRIRRSRNWQLlGEAtshQpFlhplKpp..............Ehp.shcYLI++lEsuLth.uDKlEPlEspLtRLlpQNPuITLAELMutTcCSLhQARsARFstE....	0	3	5	15
+12449	PF12615	TraD_N		F sex factor protein N terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is typically between 96 and 107 amino acids in length. The family is found in association with Pfam:PF10412. TraD is a cytoplasmic membrane protein with possible DNA binding domains. It is part of the bacterial F sex factor complex.	25.00	25.00	26.00	33.90	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.00	0.72	-3.66	24	278	2009-09-25 14:28:23	2009-09-25 15:28:23	3	7	186	0	20	265	0	98.40	51	15.94	CHANGED	hhhhhhhlllsslhhahchstp...shhsuhhYahsp.....hhthl..s.p.hhpltap......spphptohtphLps.ahltss....sphhptlhhuulhuhllshllhhl	....YsLFIhFWILlGLlLWl+ISWQ...TFlNGsIYWWCT.TLEGMRDLI..+.SQPVYEIQYY......GKTaRMNAAQVLHDKYhIWCG....EQLWSAFVLAulVALVICLITFFl........	0	0	2	12
+12450	PF12616	DUF3775		Protein of unknown function (DUF3775)	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. There is a single completely conserved residue G that may be functionally important.	21.90	21.90	22.10	27.40	20.90	19.30	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.44	0.72	-4.19	44	175	2009-09-25 15:18:47	2009-09-25 16:18:47	3	1	164	0	55	130	14	75.40	46	51.75	CHANGED	hsppElcshIssLs--Eps-LVALhWlGRG..-aps-EascAhppAtppt......ssssucYLlGpPhLuDaLEpG........L-u.LGh	.....scpELtuhIssLsEDEph-LlALMWlGRG..DasssEW--AlspApcct........sscsAcYLlGpPhLuDaLE-G....LsA.LG...........	0	14	33	39
+12451	PF12617	LdpA_C		Iron-Sulfur binding protein C terminal	Gavin OL	lg7	Prosite	Family	This domain family is found in bacteria and eukaryotes, and is typically between 179 and 201 amino acids in length. The family is found in association with Pfam:PF00037. LdpA (light-dependent period) plays a role in controlling the redox state in cyanobacteria to modulate its. circadian clock. LdpA is a protein with Iron-Sulfur cluster-binding motifs.	20.60	20.60	24.10	23.20	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.22	0.71	-5.02	45	96	2009-09-25 15:24:46	2009-09-25 16:24:46	3	8	89	0	42	102	157	186.40	40	51.44	CHANGED	sLltphssDAlEIHTpsG+tpsFppLWpslssstspL+hlAlSCst.u.............csLlchLhphapllp..s..............s..hhlWQhDGRPMSGDIGs.GTo+uAlpLup+l.....hstt...PGalQLAGGTNspTlshLcp.sh.........................................pthlAGlAaGuaARpLlpPlLcphcppt.p...............................Lc-hP-hltpAlphApuLVsPh	...............LlpphslDAlEIHTpsG+tptFppLWpplssshspL+hlAlSCst.s..............csllchLtphapllp.s....ls..........t...h.lWQhDGRPMSGDIGp.GTT+sulpLup+l.......hstt.......PGalQLAGGTNsaTlstLcp.sh................................................................pshluGlAaGuaARpllsPlLcphpppttp...............................Lc-aP-hlhpAlphApuLVsPh......................	0	7	28	39
+12452	PF12618	DUF3776		Protein of unknown function (DUF3776)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length.	25.00	25.00	30.90	29.70	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.26	0.72	-3.51	10	168	2009-09-25 15:27:22	2009-09-25 16:27:22	3	5	35	0	61	137	0	105.10	32	20.21	CHANGED	sssppcDc.shshh.tchscK.-psoS...ucsh.slSppspscsuh.-sEs.lucpcppppGsshQhc+SRuuclTushuoc..hh.s.pssccK-cspthssssscul.S.p.p	................................hssKK-ctstsh.tss-t.K...K.-p.sos.....SEsF...ulutcsl...PKsshspsEs.locpc+pppGsuhQhc+uRhsclTushssc...hh.s.pspc+K--s.pthssh.s.pp..ul.S.p..................................	0	3	6	15
+12453	PF12619	MCM2_N		Mini-chromosome maintenance protein 2	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 138 and 153 amino acids in length. The family is found in association with Pfam:PF00493. Mini-chromosome maintenance (MCM) proteins are essential for DNA replication. These proteins use ATPase activity to perform this function.	21.30	21.30	21.60	21.60	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.58	0.71	-4.24	58	331	2009-11-26 14:18:40	2009-09-25 17:02:30	3	9	280	0	227	319	0	142.50	31	16.94	CHANGED	---.-t...............-..t-l.t-h...p-h-c.t...E-.--G.DLauDshEc.DYcsp......c.DpY-ts.s..lD.D....-t-hc-hshusRRthEtpLscRD+.httt..............h..thah..s--....---Dsphp.............h.....RRRR+pa-c....-.-sh..sht..-........................hp-ElslEsL....sDlKupol	.....................................ts.......................p.......h.p...t.t...pE-E-G--Lhu.Ds.h....Ec.DYRshs......-hDpY-sp.s........lD.D....-.-h.-.-lshusRctsEtphpcRDRphupt.......................phh.shhh.....ss.-...........----tp.t...........................pR+R+ph-c..........tp.st.....th-..-..........................h.-..olEsLtDhKupo...............................................	0	76	121	188
+12454	PF12620	DUF3778		Protein of unknown function (DUF3778)	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is typically between 48 and 61 amino acids in length. There is a conserved LRF sequence motif.	22.10	22.10	23.70	22.40	17.60	15.60	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.09	0.72	-4.41	19	53	2009-09-25 16:06:54	2009-09-25 17:06:54	3	4	3	0	34	41	0	51.00	35	17.06	CHANGED	st.shhtsuhthtssshhh.sS.p.+sthllRVE...s.......s..LhLLRFNsELRGsh..LL	....................hh.ssh..t.s..hh.sS..shHsthslRVE...........s..LhLLRFNs-L+Gs.hL........	0	0	0	12
+12455	PF12621	DUF3779		Phosphate metabolism protein 	Gavin OL	lg7	Prosite	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF02714. There are two completely conserved residues (W and D) that may be functionally important. This family is likely to be involved in phosphate metabolism however there is little accompanying literature to confirm this.	22.10	22.10	23.20	22.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-10.16	0.72	-4.10	64	338	2009-09-25 16:07:58	2009-09-25 17:07:58	3	13	128	0	268	348	0	94.10	28	9.75	CHANGED	FhcPchatsactl+phlPpshth......phs.cht.cpAYhpPul.supsPhlWIPRDs..hGlScpElpcspcs.....lsloD-sAthsE.....K.G+lha.......tspPP...ac	...........................................hpPth..sat.h+thh.t............phssphh.ppAYhpPul.puppPhlWIPRD.s..hGlScpElpcspch............l.loDEsutlDc.....K.s+lha.......sttPP.a....................	0	57	138	226
+12456	PF12622	NpwBP		mRNA biogenesis factor	Coggill P	pcc	Wood V	Domain	The full-length Wbp11 proteins carry several copies of a PPGPPP motif throughout their length. This motif is thought to be necessary for folding of the molecule as it helps to bind the WW domain, Wbp11, Pfam:PF09429 [1]. This domain together with Wbp11 may function as components of an mRNA factory in the nucleus.	25.00	25.00	27.30	26.20	23.70	22.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.80	0.72	-3.48	27	69	2009-10-16 11:54:12	2009-10-15 17:08:00	2	4	67	0	48	62	2	63.90	30	21.31	CHANGED	sp+SlYYcPphNPhGtsPsG..........hP.hh+shtt......sp.sp...............hsp............................lshPp	..sp+SIYYcPshNPhGssPsu..........hP.hh+stpt.t.....sp.ss.........................................hpp............................I.hP.....................................................................................................	0	22	32	45
+12457	PF12623	Hen1_L		RNA repair, ligase-Pnkp-associating, region of Hen1	Coggill P	pcc	Gardner P	Domain	This domain is the N-terminal region of the bacterial Hen1 protein.  This protein forms stable hetero-tetramer with Pnkp. The hetero-tetramer was able to repair transfer RNAs cleaved by ribotoxins in vitro [1]. This domain provides the ligase activity of the hetero-tetramer.	20.70	20.70	20.80	27.40	20.40	20.50	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.57	0.70	-5.60	27	120	2009-10-15 16:15:24	2009-10-15 17:15:24	2	5	118	0	59	128	2	241.90	54	50.93	CHANGED	MLLTloTT.....cpP.ATDLGaLLHKHP-RlQoFshuhGpAHVFYPEAotcRCTsALLL-VDPlsLV...Rsp+ut...su.s.huLuQYVNDRPYAASShLuVALucVFpTAhsG+CcsRPELAusslPLclclssLPs.R..GGtpLlc+LFEPLGWp.VsApslsLDpsaPpWGcS+YlsLsLpG.slRLu-hLsHLYVLlPVLDssKHYWVusDEVDKLlRtGcGWLusHP-+-LIsRRYLt+ppsLscpA.....LsRLs-s	...........................MhLTloTT.....ppP.A....TDLGaLLHKHP-+sQsFshuaGpAHVFYPEAos-RCTAALLL-VDPlsLV......Rspctt........ssss..suLuQYVNDRPYAASShLuVAlupVFpoAhsGcCcsR.PELAspslPLclclPsLPs.R.........G..G.....spll..c+LFpPLGWs.VsupslsLDtpF........Pp...WGcSRYlpLsLpG.plRLuDALpHLYVLLPVLDcsKHYWVusDElDKLLRtG-GWLssHPE+cLITcRYLp++tuLscpAhpRL...h.........	0	22	46	54
+12458	PF12624	Chorein_N		N-terminal region of Chorein, a TM vesicle-mediated sorter	Coggill P	pcc	Pfam-B_PB000002 (release 24.0)	Family	Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.32	0.71	-4.56	121	1194	2009-10-16 09:35:15	2009-10-16 10:35:15	2	56	295	0	818	1223	15	109.70	25	4.37	CHANGED	hE...ulls...plLspaLGp....Yl..cslssppL.plu.lasG..cVpLcNLcLKp-....uLcpL..pLP..lplptGhlGc..Ls.lplPWps.L..tsc.PVhlpl-slal.lssPps....tpchst-c.ppppptth....KtpplpphE	.......................................thlt.lLppaLup...al..c..s..l....s......cpL.pl.u....l.h....p...G......sl.pLpNLpL+.....pc.........................s....L.p...........p...h........cLP.............lplppGhl..s..c..........ls..lp..............l.P.Ws..p..L..............hsc...Plh..lplcslhl.lhtstt.........t.p.p.t........................................................................	1	329	455	664
+12459	PF12625	Arabinose_bd		Arabinose-binding domain of AraC transcription regulator, N-term	Coggill P	pcc	Pfam-B_PB000001 (release 24.0)	Domain	AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, Pfam:PF00165, and this dimerisation domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].	22.60	22.60	22.80	23.40	22.40	22.50	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.12	0.71	-4.47	221	2712	2009-10-16 10:27:52	2009-10-16 11:27:52	2	8	847	0	796	2533	293	180.40	18	52.86	CHANGED	Gh-spslLpps..Gl..ss...sh..L..ps..thp.lshpphtpLhptu.hptssc.sslGLchu.pphphsshGhluhshhsusTLtpAlpphh+ahtlh...hhshph......ttttt....stlth.t....................pt.......h-hhhushhphh..ph..lh...sp.hs.hplphp..assP...s.t....ap..phF.s.ss.lpFststs.s.lhhssph..Ls.tPl	..............................................................GhssttlLtts..Gl.....s......t....l..t.....p.....s...psp...lsh.tp.hhplhpth...hp.hh....s....c....ss..h....G..l.p.....hu.p.p.h..ph.s.sh.G.h.luhsh.h.s.us...oLtpAlpthh.cah....plh..ssh.hphpl..........................ptpssh..stlph..p.tt..............h..............pth...h...h-.h.h.lsshhphh.........ph.lh.....upp...ht....h..plphs.......h..stPs.....thp......tYp.phF...s....ss.lpF..s.psts...t.....lhh..stph..Lshs...................................................................	0	161	340	592
+12460	PF12626	PolyA_pol_arg_C		Polymerase A arginine-rich C-terminus	Coggill P	pcc	Pfam-B_105 (release 24.0)	Domain	The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.	22.00	22.00	24.00	23.10	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.63	0.71	-4.49	70	1295	2009-10-19 10:32:25	2009-10-19 11:32:25	2	4	1278	7	247	869	313	125.80	44	27.24	CHANGED	pppG..hsshsAhppAsscllspQspphAIP+RFohshREIWpLQ.RLs..+RpG+RshpLlpHPRFRAAYDFLlLRspu.G-......phtpLupWWscaQpsssp..p+pphlpphstpttt.........p+RRRRs+++ps	......................csGLs.aDAh.shAhN-VLD-ts+s..lA.IP+RhTshhRDIWpLQhRhs..RRp...G............KRA.a..+LlEHPKFRAAYDhLtLRA-l.tss.......-hpcLupW....Ws-FQsusss...pp.csMl.splspcss.s..........................+RRpRRsR+p..s.............................................	0	50	124	193
+12461	PF12627	PolyA_pol_RNAbd		Probable RNA and SrmB- binding site of polymerase A	Coggill P	pcc	Pfam-B_105 (release 24.0)	Domain	This region encompasses much of the RNA and SrmB binding motifs on polymerase A.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.53	0.72	-4.40	312	6138	2009-10-19 12:08:10	2009-10-19 13:08:10	2	37	4516	22	1489	4542	2033	63.10	27	14.21	CHANGED	sFpI-tcTtpuIpchus..hLpplusERlhcElhKllhus.psptshchLhctGLh.phlh..Ppl.sth	.......................sFplss-Thp.sh..p..p...h...ss.......hL.p...p....l.o.....s.....E....R..lhpEhpK.l..L.h.........us..psptshphL.p.c.hslh.phl.h...Ppl....hh..................	0	481	941	1254
+12462	PF12628	Inhibitor_I71		Falstatin, cysteine peptidase inhibitor	Coggill P	pcc	MEROPS_I71	Family	This family of peptidase inhibitors is expressed from plasmodial protozoal species. Falstatin is found to be a potent reversible inhibitor of the P. falciparum cysteine proteases falcipain-2 and falcipain-3, as well as other parasite- and non-parasite-derived cysteine proteases, but is only a relatively weak inhibitor of the P. falciparum cysteine proteases falcipain-1 and dipeptidyl aminopeptidase 1. Thus, P. falciparum requires expression of falstatin to limit proteolysis by certain host or parasite cysteine proteases during erythrocyte invasion.	22.10	22.10	23.20	63.40	21.50	18.30	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.23	0.71	-4.60	4	9	2009-10-19 12:24:47	2009-10-19 13:24:47	2	2	8	1	6	11	3	162.40	42	31.47	CHANGED	DppYpLsGsEpCDs.lKLGsIlNpTNpcTIshSLoVscshCIshEusuGsGYlWsLLGVHKpcPhINPEpFPpKhlpKsaFSpEISVTQPKthphsp.sspKNsspsspsuuQNpssos+P.KPc...pllGGss.lpSlIKuHKsGKYalVYSYYRPFsPTusANTKIlpLTVQ	.........spp.tLpssE.CDp.lKLGsIlNpsNpcTIphshsVsplLCIsLEu.sGsGalWsLLGVHKccPhIsPEpFPpKhlpcSaFSp-ISVTpPht.hph..sp.sspcssspptpssspNpssp.+P.psc...pllGGsshlpShIKsHKsGcYaIVYSYYRPFsPTtssNT+IlpLsVp....................................................................	0	1	2	5
+12463	PF12629	Pox_polyA_pol_C		Poxvirus poly(A) polymerase C-terminal domain	Bateman A	agb	Structure	Domain	This domain is found at the C-terminus of the pox virus PolyA polymerase protein [1].	27.00	27.00	48.10	48.00	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.33	0.71	-4.59	13	66	2009-10-19 14:10:58	2009-10-19 15:10:58	2	2	44	9	0	62	0	197.10	65	42.22	CHANGED	LLsMlKMFSQIDRLEDLscs.EKhplRhuTLLEYsR...hcauIhhsGc...psphshpssh....shspRllTVDs+pY..shsacKChlYLDEss....................LspcIhchs..uD-u.lDFEsV......oNSsaLIcsssh...................YTYFSN....TlLhpscsclH-ISs+uloAHIL...lYplLT+sshtp.sLuDllNSLlshE...KhPlaplIPRDKKsG+HGIIDIEKDIIsH	.LLNMIKMFSQIDRLEDLoKDPEKFsARMAThLEYVR...YTHGIlFDGc...+NNMPMKClI........DcssRIVTVsTKcY...FSFKKCLVYLDENV....................LSSDILDLN..ADousDF.ESV......TNSVYLIHDNIM...................YTYFSN....TILLSDKGKVHEISARGLCAHIL...LYQMLTuG-Y+Q.sLSDLLNShMsR-...KIPIYShsERDKKsGRHGhINIEKDIIl..	0	0	0	0
+12464	PF12630	Pox_polyA_pol_N		Poxvirus poly(A) polymerase N-terminal domain	Bateman A	agb	Structure	Domain	This domain is found at the N-terminus of the pox virus Poly(A) polymerase protein [1]. According to SCOP this domain contains a helix-hairpin-helix motif.	27.00	27.00	38.20	85.80	24.10	23.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.44	0.72	-3.95	13	66	2009-10-19 14:14:05	2009-10-19 15:14:05	2	2	44	9	0	61	0	112.10	65	24.00	CHANGED	MNp........p..hpllcpYLGR.PShsEYahLKpQh+sIp+IhtFNKDlFlu...LlKKNK++FFoDlc..sSsuEIKcRlhpYFoKQcpsp.plG+LhoIIELQolLVooaTclL........GVLTs	........ohsN....IslcIIEsYLGRlPSlNEYHMLKLQsRNIQKIslFNKDIFlS...LVKKNKKRFFSDlD..TSuSEIK-RILSYFSKQTQTY.sIGKLFTIIELQSVLVTTYTDILGVLTI............	0	0	0	0
+12465	PF12631	GTPase_Cys_C		Catalytic cysteine-containing C-terminus of GTPase, MnmE	Coggill P	pcc	Pfam-B_102 (release 24.0)	Family	This short C-terminal region contains the only cysteine present in these proteins. It is proposed that MnmE is a tRNA-modifying enzyme and that Cys-451 functions as a catalytic residue in the modification reaction.	22.00	22.00	22.00	23.30	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.45	0.72	-3.57	534	4286	2009-10-19 15:56:53	2009-10-19 16:56:53	2	10	4170	8	1009	3196	2082	72.50	33	15.93	CHANGED	ttsspsshlsptRHhpsLp.pAhptLp.ps...........hpslp.......tt.....hs...............h-l...hu.-LRtAhcsLucIT..G.c...hs.s.-.-lLspIFSpFC	..............................................................s...t-sshluppRHlptLc.pAtppLppu.............tptlp......ts......hs....................................................................h-L..lu.-L+hAhptLuEIT...............G.-....hs.sD.-LLspIFSpFC...............	0	338	634	843
+12466	PF12632	Vezatin		Mysoin-binding motif of peroxisomes	Coggill P	pcc	Wood V	Family	Vezatin is a peroxisome transmembrane receptor that is involved in membrane-membrane and cell-cell adhesions. In the movement of peroxisomes it binds to class V [2] and class VIIa [3] myosins to guide the organelle through the microtubules [2] and allow pathogens to internalise themselves into host cells [1]. Vezatin is crucial for spermatozoan production [3]. In mouse cells it interacts with the cadherin-catenin complex bridging it to the C-terminal FERM domain of myosin VIIA [4].	22.30	22.30	23.80	23.90	21.00	20.70	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.72	0.70	-5.30	32	191	2009-10-20 13:22:29	2009-10-20 11:54:41	2	3	153	0	121	198	1	252.80	27	36.68	CHANGED	sshhhlshLlphsphttsshh....h.......hhhlllhlhhslhththhc.....lphh+ppsltplpshlssspshsshhppslhhl..p..El-lhSpuhp.......................t.tpptpspph.tL+ctLppsls.hh.phpputpplh.hhs.........sssLpcYhslYsl...............s..sLt.........................h.p...................pptc-........................t.olptL+hhht.....+hphlRKhhLCpLLolpt......ts.stsshh........................................................capslhptlpsLspslsph	.......................................s...hhlshLlth.sp..hhs..s.sh.hhth......................lllhlhllhhulhhatht+........LphhhpphhsplpshlssupsFsshsppultLI..Q..EsEllSRGap...................uss..shut.....pp.sp.+hltLR+slhpslpthhpshp...uphhhhhhhs...............ssslppYhslh.sl................pphsLs.....................u.pt...hs-...................ppscs.............t.SL.sL+.hLht.....p.chhR+hhL..LLuhss.........sG...sshh...............................................................................chsshhptl+sLp.hhp.........................................................................................................	0	25	53	91
+12467	PF12633	Adenyl_cycl_N		Adenylate cyclase NT domain	Finn RD, Bateman A	agb	Ref [1]	Domain	\N	21.60	21.60	21.60	21.90	21.30	21.50	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.30	0.71	-4.79	18	1003	2012-10-02 22:47:23	2009-10-20 16:23:27	2	7	911	0	113	583	22	184.90	65	24.20	CHANGED	Mt.clpph+p+lDtLsplRl-RALuuhssphpcVFpLlPLLLHhNHPtLPGYls.ssPpGIspFplo-hQppaLssh........................hphp.....t......hpsspssIhGlYuMGSTuSIuQospSDLDlWVCasspLosc-hpLLppKspLlppWAcpasVElNFaLhcpp+FRpppsus......hstEsCGSuQHhLLLDEFYRSAlRLAGK.LLWh	..........................................................................................M.hYlpTL+QRLDulNQhRl-RALAuMussFQpVasLLPsLLHapH..PLhPGYl-..G.....s.VPp..G.IshasPs-p.QppaLs-L........................t.t.h.s......t......spuchPIsGlYoMGSTSSlG.QSsS.SDLDIWV.CH.Q.S.WL.DuEE.RQLLQRKCSLLE.sWA.A.S.LG..VEV.SFFLIDENRFRHNESGS......LGGEDCGSTQHILLLDEFYRTAVRLAGKRILW.s.................................	0	16	40	81
+12468	PF12634	Inp1		Inheritance of peroxisomes protein 1	Coggill P	pcc	manual	Family	Inp1 is a family of peripheral membrane proteins of peroxisomes. Inp1p binds Pex25p, Pex30p, and Vps1p, all of which are involved in controlling peroxisome division. The levels of Inp1p vary with the cell cycle, and Inp1 acts as a factor that retains peroxisomes in cells and controls peroxisome division [1]. Inp1p promotes the retention of peroxisomes in mother cells and buds of budding yeast by attaching peroxisomes to as-yet-unidentified cortical structures [2].	20.70	20.70	21.80	20.80	19.20	18.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.87	0.71	-4.52	28	115	2009-10-20 15:46:51	2009-10-20 16:46:51	2	2	114	0	83	108	0	140.90	28	25.09	CHANGED	stspcsoLFpasssKIl...........t......................h...hspspo.shpppsppllupGshcIaplpsu...........................pssaLssG...shVaPlL.P+hplhpl...ptpsspFlL.lhsPpp.YW+IElss.....p..--tpllcphcpllsplspYps	........................................................................................sLatasss+ll............php.....t.....u.pss.........hp.s.s..p.pshshpppspphlAhGslcIaplssu............................................ssFLssG...sllaPlL.PKsQsapl.....stpuspFllplhpPp..Ya+IElsst.......sp.E-pphlcphcpVlspllpac..............	1	12	39	68
+12469	PF12635	DUF3780		Protein of unknown function (DUF3780)	Bateman A	agb	Bateman A	Family	This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria. Proteins in this family are typically between 189 and 206 amino acids in length. There are two conserved sequence motifs: PEERWWL and GWR. This family is found in a very sporadic set of bacterial species, suggesting that it may have been horizontally transferred. One protein is annotated as plasmid borne.	21.70	21.70	22.30	22.20	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.45	0.71	-4.78	12	34	2009-10-29 09:18:49	2009-10-29 09:18:49	2	2	34	0	15	37	6	187.40	38	93.73	CHANGED	Msp................ptpshGFGhsss.ssHpFhV.IPsu+spsVhlhEpauhpuGpsup.................ss...t.RspLs+ptWptlucslcpcFNpRL+cpphpsuRW.KsGcN.V-.RLLGKELsVLsWAlE.sAss-plPsAlpNWpuL+PEERWWLashTsAtsGtspcst.pGWR+AlRhALs-sP................t...h.s+p.h.............spscppphshhcp	................tttslGFGhsssps.HHFhV.IPp.upss..sVhlhEpashpssppsp..............................................ps..h.+shls+.pWptItstlppcFNtRL+pcshpsu+W..KsGpN...sVc.RLLGKELsVLsWAlE..cs.sscplPlAl+NW.uL+PEERWWLasMTsAuTGts.pDpt.+GWRhALRaALs-sP.................sp....p................p.....................................	1	8	10	13
+12470	PF12636	DUF3781		Protein of unknown function (DUF3781)	Bateman A	agb	Jackhmmer:Q17ZV8	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 82 and 98 amino acids in length. There are two conserved sequence motifs: GKNWY and ITA.	27.00	27.00	28.10	32.00	24.10	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.26	0.72	-4.02	19	84	2009-10-30 16:24:37	2009-10-30 16:24:37	2	6	80	0	15	75	3	72.10	47	72.53	CHANGED	LLpNl-.+lHTT-LGh.RI++NLsLcss-V.l-...aCKpKIhs.ssAhIp++GKNWYsps-s..shlTlNAaSYTIITAH	.....LLpNl-.+LHTT-LGhhRI++NLuL..ssp-V.lp...aCKpKIhs.ssupIpR+GKNWYlps-s..hhITlNAhSYTlITAH.......	0	10	14	14
+12471	PF12637	TSCPD		TSCPD domain	Bateman A	agb	Jackhmmer:Q17ZZ5	Domain	This family of proteins is found in bacteria, archaea and viruses.  The domain is found in isolation in many proteins where it has a conserved C-terminal motif TSCPD after which the domain is named.  Most copies of the domain possess 4 conserved cysteines that may be part of an Iron-sulfur cluster. This domain is found at the C-terminus of some ribonucleoside-diphosphate reductase enzymes.	21.60	21.60	21.60	22.60	21.50	21.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.07	0.72	-4.04	149	1269	2009-10-30 17:23:21	2009-10-30 16:52:16	2	33	1088	0	416	1079	1406	91.80	27	13.21	CHANGED	acsps.sC....shhlslsh-.t.s...........lhtslshsGGC.suphpulu+Ll.......pGhs...lc-....llcpLcGIpCsspss.....................SCPDtlucALcphh	.................................s..sp...phYlshsth...t..c...G........hElFl.s.htptG....us.tuhhpuhuthlShsLp.....hGss......l-p....hlcphpslchtssGhh.t............t.h.SlhDhlh+tLt...h.....................	0	186	331	383
+12472	PF12638	Staygreen		Staygreen protein	Bateman A	agb	Jackhmmer:Q181L4	Domain	This family of proteins have been implicated in chlorophyll degradation [1,2]. Intriguingly members of this family are also found in non-photosynthetic bacteria.	27.00	27.00	27.60	27.50	23.10	19.60	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.96	0.71	-4.67	21	155	2009-11-02 14:20:47	2009-11-02 14:20:47	2	3	98	0	61	150	2	143.00	41	65.43	CHANGED	spFsssKLpVpFhsstspstPh.....hPRpYTLTHsDhTucLhLsIupshshs.pl....sch.RDEVlAEW.pc.psp..hsL+VasaVS.GuphhhshuAp.RahIFp+ELPLlLcAlhaGDpsLFppaPcL.sA.VaVaFcSs..hP.....pa............s+hEsWGslp-hu	.........s.hFpssKLpV.Fhs..sspp..ppPh................hsRpYTLTHSDhTucLhLsIupshshs.pl.....sphtRDEVluEW.+csp.......sp........hsL+Vasalu.GsphhhchssthRahIFp+ELPlsLcAlhaGDpshFspaP-Ltpu.laVaFpSs..hs.ca...................N+lEsWGslp-h.s...................	0	18	48	54
+12473	PF12639	Colicin-DNase	Colicin-DNAse;	DNase/tRNase domain of colicin-like bacteriocin	Coggill P	pcc	pdb_1bxi	Domain	Colicin-like bacteriocins are complex structures with an N-terminal beta-barrel translocation domain (Pfam:PF09000), a long double-alpha-helical receptor-binding domain (Pfam:PF11570) and this C-terminal RNAse/DNase domain with endonuclease activity. Their competitor bacteriocidal action is by a process that involves binding to a surface receptor, entering the cell, and, finally, killing it. The lethal action of colicin E3 is a specific cleavage in the ribosomal decoding A site. The crystal structure of colicin E3 reveals a Y-shaped molecule with the receptor binding domain forming a 100 Angstrom long stalk and the two globular heads of the translocation domain and this catalytic domain comprising the two arms [2].	21.50	21.50	21.60	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.87	0.72	-3.81	57	525	2012-10-05 18:28:12	2009-11-02 18:40:55	2	27	407	56	43	461	2	108.50	29	25.68	CHANGED	sshspsG................a.ths...sthss.ls.phtcpLp.....ucchspFcphpcthhpsl...............tpsspltppFstpphpth.psthsP...............ppaphHHppp..tG.......shpllsschHtp.....hHpG	...............................................................................................................................................................................................................c..pphsphRKphhcsV...............ucss-huup.....F...s....s.....c....s....lt..ph.+p...GpsP...........................................................hsYslHH+hslpsGGss.ch-NlhLlpsc.Hcc........................	0	5	14	22
+12474	PF12640	UPF0489		UPF0489 domain	Bateman A	agb	Jackhmmer:Q181H4	Domain	This family is probably an enzyme which is related to the Arginase family.	27.00	27.00	28.50	27.80	25.00	23.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.29	0.71	-4.04	34	190	2012-10-01 22:40:15	2009-11-03 13:56:57	2	4	158	0	102	176	2	174.40	25	49.67	CHANGED	lall-sHccshhhWhctlppt.h...pshpllHlDpHsDhhhsh...................phshphshpt......t......phshctlsh.-saI..hsAlhsuhlsclhhlppshs................................................hh.t...h.....t....hpphptht.htshshpp.hhpt..sh...........................................................................p.ppsalLDIDLDaF	...................lalV-sHpcsl..........ahhcsltppcls..pshph..lHhDuHsDhhlPh......................................................shssssshsc...................cthhspLs.I..-NaI....hPulauGah.s.clhalcssau...............................................p..hthst...hhhspt.h.s........ttp.......hpp.h.hp.hps....h.hps......t................................................................................................................................................................................................................................s..psalLDlDLDaF..............................................................	0	38	53	78
+12475	PF12641	Flavodoxin_3		Flavodoxin domain	Bateman A	agb	Jackhmmer:Q180M7	Domain	This family represents a flavodoxin domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.82	0.71	-4.81	44	396	2012-10-03 05:08:30	2009-11-03 16:27:47	2	6	311	0	78	1420	207	144.70	24	88.08	CHANGED	hllYSShTGNT+plAcuItpslss..pshhshpcsps.....hsph..DllhlGFWsDKGssspchtcalps.L+sK+lhlFGThGhsssscahpphlppspphlsps.NpllGpFhCQGKhs.plpc+acph....tpstpptthsphlppa-pAhsHPDpsDlppucphsc	..........................llY.s.S.h.o..GNT+plAcsI....tctlss...........tph.h.....s.h..p..ps.ss.....................hpsa....D.h.l.hlG...h......W......s.........D..c..G......p......s......s...t..c.........h......p....c...a....l.......p.....p.....l......c.....s.....K....p....l.....h..lFu...T..h..G....s..t........s..p..p..a.h...p..p...h...h.p.p.h....t....p.h..hs...pt...sphh...s...th...hs..p......G...t.h.s..t........h.thh.t.......................t.h..s..cP.s..ch..h.....t.........................................................................................................	0	30	61	71
+12476	PF12642	TpcC		Conjugative transposon protein TcpC	Bateman A	agb	Jackhmmer:Q180I0	Family	This family of proteins are annotated as conjugative transposon protein TcpC. The transfer clostridial plasmid (tcp) locus is part of some conjugative antibiotic resistance and virulence plasmids. TcpC was one of five genes whose products had low-level sequence identity to Tn916 proteins, having similarity to ORF13 homologues from Tn916, Tn5397, and CW459tet [1].\	 This family of proteins is found in bacteria. Proteins in this family are typically between 302 and 351 amino acids in length.	27.00	27.00	28.00	27.80	26.90	26.10	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.47	0.70	-4.81	47	781	2009-11-04 11:35:59	2009-11-04 11:35:59	2	2	512	6	62	457	7	223.70	29	72.09	CHANGED	saspsFsppYho....tspcsh-pRtppLp.tYlspphp..ststhpt.......sppltssplhslcpp.........cpthhlphpVphphs..............ptcptpp....................pthsVPVth....pssshslsu.Pshss.hsppushpspttpscsshst.tt......pclpcFLpsFFchYssuspp-lshhhpsss......slsssh...th........tclsssphhpppsshpsslt............Vpah-pt.....optphsppasLpLp.cp....sspahlpc	..............................................................................FscsFscsYao..hppspcsh-pRhppLp.tYLsp-hpshs.cts+pt......suslpshplhslcpp..............cspaslpapVc.pls.......................pscptpslp............................ssapVslhh.........tssshlllp.Pshss..hPp.p..u..s.....hpsK.th.-scsss-stss.........pclspFLpsFFchYsoust..p-.LuYasssshh.....slstph....ha...........pclsss.h..hhcc.....s.sps.hlsls............VpahDpp...............oc.sTpsp.pasLsLp..Kp.....sssWhIh...................	0	30	44	53
+12477	PF12643	MazG-like		MazG-like family	Bateman A	agb	Jackhmmer:Q181R3	Domain	This family of short proteins are distantly related to the MazG enzyme. This suggests that these proteins are enzymes that catalyse a related reaction.	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.18	0.72	-4.06	25	305	2012-10-01 21:36:44	2009-11-04 14:23:11	2	3	298	0	61	203	5	93.40	35	86.29	CHANGED	Ih+NlKhIEtLKuELLs......pluclF+hLs+Gup...p-uIl-sluslIllsYlLucRLGhsapclDcslccKL+luIhEccc.lEK.ht-LScLtp+L......cc+c	..........................................tRNh+.hcs.Ks.hlu......-LhEL...Fphhosp.p......s...tp......t..E..cIt-ELADllIYsYhlADpLGhD....lDEhlccKLccs.t.h.chs...Ec..................................	0	25	45	57
+12478	PF12644	DUF3782		Protein of unknown function (DUF3782)	Bateman A	agb	Bateman A	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 91 and 186 amino acids in length.	21.60	21.60	21.70	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.06	0.72	-4.18	54	159	2009-11-04 17:31:12	2009-11-04 17:31:12	2	7	87	0	50	145	10	79.80	20	52.38	CHANGED	pchtchpc...........................................chtphpcclpph................................................................hsccphchlp........................chhstlstthshtsEpsa+pGhp-slphhtt	....................................................................................................................................................................th.c...............................phhthpccLpph...................................................................hocEs....hchlp..............................phhstlutths..sEtta+.Ghpthlp..........................................................................................	0	17	23	28
+12479	PF12645	HTH_16		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q180H2	Domain	This domain appears to be a helix-turn-helix domain suggesting that this might be a transcriptional regulatory protein. Some members of this family are annotated as conjugative transposon domains.	21.60	21.60	21.60	21.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.88	0.72	-4.04	52	618	2012-10-04 14:01:12	2009-11-05 10:29:19	2	3	295	0	35	325	44	61.90	36	77.88	CHANGED	aplIht.AspGDspAlpplLpHYcuYIsphsh+.hhc.chGpshhtlD--l+pclct+Llps.llpFc	........a.lIhp.ApcGDspAlpplLp+YcuYIs+hshR.hhs.-hGphphhVDEph+pclcp+LIpt.ILpFc........................	0	17	28	28
+12480	PF12646	DUF3783		Domain of unknown function (DUF3783)	Bateman A	agb	Jackhmmer:Q180F4	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.	27.00	27.00	30.80	30.00	25.30	22.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.59	0.72	-4.22	69	284	2009-11-05 10:33:20	2009-11-05 10:33:20	2	1	262	0	72	251	7	58.20	26	39.88	CHANGED	pchllhssh.ssp..clcphlpth+ct....th..phslhAslT.sNhpWshppLh.cEltcE+chhp	...chllhssh.ssp...clpthlpsh+ct....tl...phslhAslT.sshsWshppLl.cElhcE+chhp...	0	35	57	68
+12481	PF12647	RNHCP		RNHCP domain	Bateman A	agb	Jackhmmer:	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 143 amino acids in length. There is a conserved RNHCP sequence motif.	24.00	24.00	25.00	37.20	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.97	0.72	-10.73	0.72	-4.16	27	115	2009-11-05 10:59:04	2009-11-05 10:59:04	2	2	95	0	46	118	8	87.30	46	61.11	CHANGED	spsssFpChtCGhtVsstusGos+RNHCPsCLpShHlD.phPGDRAus.CtGhMcPlulhsRpsG-WsllHRCppCGcLspN.....RluuDDN.hhLhp	..s.tpsFhChtCGh.V.s.usGotaRNHCPpCLhShHVD...PGDRuus.CtGhM-PlulhV+psG-WhllHRCppCGpLssN......RlAuDDN.hhLh.................	0	20	36	44
+12482	PF12648	TcpE		TcpE family	Bateman A	agb	Jackhmmer:Q180I5	Domain	This family of proteins includes TcpE a conjugative transposon membrane protein.This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 168 amino acids in length.	22.20	22.20	22.90	22.50	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.39	0.72	-3.90	31	672	2009-11-05 14:27:45	2009-11-05 14:27:45	2	2	429	0	44	272	10	98.40	39	70.53	CHANGED	sYsphaphphhlYpItc.hpLPh.s..lshpph....shFllhhlslhlhhtlhs.........htpshhhhhh.hlPhhlshhhsphch-GKphhtalhshlpahhch+hpppthhht	.............sYsphaph.hVlYtIsD..hpLPh.s......lshsph....saFll..h.hhl.hlh.hpl.s.s............hhpGsh.L.pYh.slPsslTaahopKpFDGKKsasFL+uhls.Yhhc.Klshsst...p........	0	23	33	38
+12484	PF12650	DUF3784		Domain of unknown function (DUF3784)	Bateman A	agb	Jackhmmer:Q180M1	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 96 and 110 amino acids in length.	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.35	0.72	-4.05	48	316	2012-10-01 21:33:42	2009-11-06 14:28:11	2	2	238	0	39	256	75	92.90	24	80.06	CHANGED	hhlull....hhllulh..lhpsKushLloGaNohsccE+cchDpppls+hhGphhhhhul..lhllsul....hthhhsph........hslhhhllhllhhhhhlhhsschp	...................hlull..hhhluhh.......ltst+tshLluGaN....cE+chhDcp+Ls..+hhGhhhh.lhul..lhhltul....hthhhsph............hhhhhh.hlhllshllhhhhss...h..........................	0	18	31	33
+12485	PF12651	RHH_3		Ribbon-helix-helix domain	Bateman A	agb	Jackhmmer:Q17ZT4	Domain	This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.70	0.72	-4.23	28	354	2012-10-02 18:44:02	2009-11-06 14:36:52	2	4	316	0	62	379	17	42.50	33	41.58	CHANGED	pRpphosolsp-Lhp+LcpLSccTpIPhS+LlDEAl-hLLc+Yc	..........hpphohplspElhp+LDslScsp.u.l.sKScllcEAlptaLpph...........	0	25	39	51
+12486	PF12652	CotJB		CotJB protein	Bateman A	agb	Jackhmmer:Q181Y6	Domain	CotJ is a sigma E-controlled operon involved in the spore coat of Bacillus subtilis [1]. This protein has been identified as a spore coat protein [2].	29.00	29.00	29.00	31.20	28.80	28.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.67	0.72	-3.90	71	380	2009-11-09 12:44:13	2009-11-09 12:44:13	2	2	344	0	68	260	3	77.60	41	85.47	CHANGED	cppLLppIptlsFull-lsLYLDTHPsDppAlp.apphspptpphhcpYpppaGPLs.thsss..st.............p.W.sWlpsPWP.....W-	...h.hpLLcplppl-FsllELsLYLDTHPcDppAlppaNphupppppLpppaEppYGPLppaGs.u...s.p.............ssW.pWscsPWPWp.......	0	36	54	59
+12487	PF12653	DUF3785		Protein of unknown function (DUF3785)	Bateman A	agb	Jackhmmer:Q181X2	Domain	This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. These proteins share two CXXC motifs suggesting these are zinc binding proteins. This protein is found in clostridia in an operon with three signalling proteins, suggesting this protein may be a DNA-binding transcription regulator downstream of an as yet unknown signalling pathway (Bateman A pers obs).	27.00	27.00	186.90	186.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.89	0.71	-4.32	8	29	2009-11-09 15:44:53	2009-11-09 15:44:53	2	1	29	0	4	16	0	136.60	56	100.00	CHANGED	M-.YKFsYD-KEYlLsc-NCsshFND...EpcElcGlSl-cILchLspuEEVsFupEYYp-sCs.ChsGhEEKpKhFsFLEYHFYIYTK-sKYVISsIsKEY-spSFNKLhRAsKVDcSYIVSllVCtNCGsYsIpIEpCpV	..h..aKFsaD-KEYhLsE-ph.hhFN-...t.t-VcGhsI-Klh-ILNpuEtVsFuptYYpssC..ChtGlEEKKK.FPFLEaaFaIYoKsGcaVISNIpK-YcGLSaNKLhRspKVDcSYlVslsVCcNCGsasVplEphpV.	0	2	4	4
+12488	PF12654	DUF3786		Domain of unknown function (DUF3786)	Assefa S, Coggill P, Bateman A	agb	Pfam-B_16102 (release 23.0) 	Domain	This presumed domain is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 201 and 257 amino acids in length. Some proteins also contains an iron-sulfur cluster.	27.00	27.00	27.70	50.20	22.80	20.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.88	0.71	-5.01	53	182	2009-11-09 17:15:17	2009-11-09 17:15:17	2	2	71	0	79	186	21	177.60	23	80.83	CHANGED	hDhpplupphGs.h.t.ptpt...lpl.hhGpsaplshsshthsstcsssh..........hpllllcYLhpus.sts.ss.cWlsa+-lssGt.ah..ssFppc.s.psLschassp.hcphppssctLGGp.hstu......DhuhhhpslP+lPlhllhWpu..D--FPupuslLFDpssspaL.ssEslhsluthlsphL	....................h.s.tplupphusth...p.pt...htlpahuppatlshssspl...hstpssth...................................hplllLpYLhpup..sh...s..ss.caloa+El.s.s.G.thah..ssFppp.shpsLtchFusp.hcth.ppsspp...LGGp.hshu......Dhuh..hhpshPclPltllhWpu..D-EFPususlLFDssssphL.ssEslhslushlsth....................................	0	61	79	79
+12489	PF12655	DUF3787		Domain of unknown function (DUF3787)	Bateman A	agb	Jackhmmer:Q185C1	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in Clostridia. Proteins in this family are approximately 60 amino acids in length. There is a conserved TAAW sequence motif that may be functionally important.	20.70	20.70	21.80	23.00	20.00	18.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.57	0.72	-4.24	14	76	2009-11-11 17:47:45	2009-11-11 17:47:45	2	1	75	0	24	52	0	51.40	47	87.27	CHANGED	pcpKcphhshPlEpHsTAAW.ANIcchKshSpVsIPoEppVcNAK-WVDsNpK	.......................pppKcphhthPIEpHcTAAW.ANIpphKPpSsVsIPSE.pVpNAKEWVDsNpK....	0	15	21	23
+12490	PF12656	G-patch_2		DExH-box splicing factor binding site	Wood V, Coggill P	pcc	Pfam-B_900 (release 24.0)	Domain	Yeast Spp2, a G-patch protein and spliceosome component, interacts with the ATP-dependent DExH-box splicing factor Prp2 [1]. As this interaction involves the G-patch sequence in Spp2 and is required for the recruitment of Prp2 to the spliceosome before the first catalytic step of splicing, it is proposed that Spp2 might be an accessory factor that confers spliceosome specificity on Prp2 [2].	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.93	0.72	-4.13	74	304	2012-10-01 21:03:39	2009-11-12 14:11:33	2	12	256	0	228	1568	9	76.80	33	18.52	CHANGED	tp.spppthcpclsstP-pssh-..-YcplPVEpFGtA..hLRGMGWc......tupshu+sptt.................ht.ppRss.tLGLGAcshtsp	............................................ht.....tt.p.chttt...s.-pssh-........-Y.c..s.....lP..V.......E......p..F.......GhA...hLRGMGWc......tGpshG+.s.t.tt..............sts.h...s.phRPt..tLGLGAc.h..s....................................	0	78	129	190
+12491	PF12657	TFIIIC_delta		Transcription factor IIIC subunit delta N-term	Coggill P	pcc	Pfam-B_74169	Domain	In humans there are six subunits of transcription factor IIIC, and this one is the 90 kDa subunit; whereas in fungi the complex resolves into nine different subunits and this is No. 9 in yeasts [1]. The whole subunit is involved in RNA polymerase III-mediated transcription. It is possible that this N-terminal domain interacts with TFIIIC subunit 8 [2].	27.00	27.00	27.10	27.40	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.30	0.71	-4.55	35	186	2009-11-13 16:10:32	2009-11-13 16:10:32	2	15	151	0	131	188	0	162.20	21	22.39	CHANGED	pshPoshssluWSsDGclAlusuctVpl.L...........sPp.......................pt..ttspshsssshpaphsphcsshh.s.pphP.................thhspshsh.hs.t........t-.psu..........plhuluWSP.GLup...p.......RClLAVLToshtLolapsstt...pucWsclsslschLt.....................................t..t....tts.hh.........pc.plpuhsWs	........................................................................p...ssh.pslsWSpDs.pluVsssc.ltlL.............sPt..............................................................t.t..ts.t.....t........ththh...psp.h..s....st.s.......................................th..t.h.s................t.t...................thhthuWSP.G.hsss..t.........................+ClLAsLTssspLslats.t....p.pWh..pl.sslschhh........................................t....st.............p....t......thta................................................................	0	30	65	100
+12492	PF12658	Ten1		Telomere capping, CST complex subunit	Coggill P	pcc	Wood V	Domain	Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex [1]. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast.  Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [2]. Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms [4].	21.60	21.60	21.70	21.60	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.58	0.71	-4.36	27	90	2012-10-03 20:18:03	2009-11-13 17:26:38	2	2	88	4	62	79	0	132.90	26	80.45	CHANGED	Mo....sP.ssphh..............Fh.pphsshstsp+lRhLu.................sVppYshssG...pLhL-+..shst.......t.t.ss.....lsVDlshlLss.lpsc.................clplGsWlNllGYlctpt.............................................................hVcAlhlhsusulplscY..cclLp	.............................Mo....sPhs.p.h..............hhpp.sthtsup+lRhLu.................CVssYshtsG...pLhLc+.......shsh..........................ptt.sp.....................spVDlpllLps..lpsp............................plplGsWlNllGYlpttt.........................................................tpsshlpAlhlhssushcltcY.pchl.......................	0	9	30	49
+12493	PF12659	Stn1_C		Telomere capping C-terminal wHTH	Coggill P	pcc	Wood V	Domain	This domain consists of tandem winged helix-turn-helix motifs. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex [1]. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [2].	25.00	25.00	26.40	49.70	21.90	19.30	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.61	0.71	-4.31	10	23	2009-11-13 17:32:48	2009-11-13 17:32:48	2	1	23	2	15	23	0	124.20	41	26.69	CHANGED	hKuhDslctcsap-lLspLsppGLIslcupop..lcLhsLKsla-Ysp+RIusLlKLQshTGslchs+Vpp..+LphPhhopphIVDlaKEsL++hptt.splLpsWWI-hcs+sth.......hlHFpYspup	............hKShDsLcpEsFcDlls+LlspGLIsLcs+os..hDLhPLKsLa-YspKRIslLhKLQChTGTlplo+Vpc..KLclPhlTspuIVDlFKEsLK+tpKphPplLKsWWIDLcscsth.......llHLEYsts.h..	0	2	7	13
+12494	PF12660	zf-TFIIIC		Putative zinc-finger of transcription factor IIIC complex	Coggill P	pcc	Maraia R, Wood V	Domain	This zinc-finger domain is at the very C-terminus of a number of different TFIIIC subunit proteins. This domain might be involved in protein-DNA and/or protein-protein interactions [1].	22.10	22.10	22.50	22.70	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.19	0.72	-11.02	0.72	-4.09	16	171	2009-11-13 18:18:58	2009-11-13 18:18:58	2	11	153	2	124	170	0	90.00	25	12.66	CHANGED	+shpshps.u........EpCslC......cuslsasssppApCssGHhWhRCuLTFhulQsssh.+hCslCs.sthhstshttspp.....................hchLhpshssCh..aCuuchh	..........................hsp..................EpCshC..........pt...l..s.hps.hcp......uh.CssGHh.ahRCslThhslps.th..+hC.lss.phshp..t....ts....t..............................................................................hphL...p.t....C.aCss...h............................................	0	30	57	92
+12496	PF12661	hEGF		Human growth factor-like EGF	Wouters M, Coggill P	pcc	Wouters M	Domain	hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan.  The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC.  These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin.  Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.	18.00	13.60	18.00	13.60	17.90	13.50	hmmbuild  -o /dev/null HMM SEED	13	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.16	0.73	-5.96	0.73	-3.51	521	6130	2012-10-03 09:47:55	2009-11-16 12:53:17	2	1671	227	11	3408	13199	236	13.00	50	2.13	CHANGED	pCpCssGaoGspC	......pChCssGaoGtpC..	0	1352	1597	2396
+12497	PF12662	cEGF		Complement Clr-like EGF-like	Wouters M, Coggill P	pcc	Wouters M	Domain	cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin.  Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.	26.60	26.60	26.60	26.60	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.20	0.72	-4.29	733	2407	2012-10-03 09:47:55	2009-11-16 13:04:43	2	940	145	0	1458	7661	32	23.80	49	2.31	CHANGED	SapC..s...C..sGYp...........h.........s.-u.ps.........CpDIDE	......SapC.....p.....C...sGap...........Ls.........s.DG.+s.........C.p.DIDE........	0	669	767	1040
+12498	PF12663	DUF3788		Protein of unknown function (DUF3788)	Bateman A	agb	Jackhmmer:Q189D9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 137 and 149 amino acids in length. This family may be distantly related to RelE proteins.	25.00	25.00	27.40	27.10	23.30	21.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.33	0.71	-4.48	39	174	2009-11-19 14:09:27	2009-11-19 14:09:27	2	5	124	0	34	153	9	124.80	26	87.02	CHANGED	sppphPo.cplpsalGpsh...apclpphlpppYt..hph-ashsutphGWslKa+..KtsKsLCslasccshFsshlhlGp+ctpch-thh.shostlpchacpspshss.G+Wlhl-lpspshlp.DlhcLltlKt	...............pphPs.cpltthlup.sh...appLpphlpppYs...phcashsutphGWshK..Y+.........KtuKsLCslasccshFsshlhlGccctt..ph-thh.phos.spclaccspshss..G+..WLhhclpspshhp.DlhcLlpl+p.........	0	18	30	32
+12499	PF12664	DUF3789		Protein of unknown function (DUF3789)	Bateman A	agb	Jackhmmer:Q18DB3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two completely conserved residues (V and C) that may be functionally important.	22.00	22.00	23.10	22.40	20.90	20.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.30	0.72	-7.34	0.72	-4.63	11	148	2009-11-19 14:19:49	2009-11-19 14:19:49	2	1	103	0	8	89	6	33.20	46	71.96	CHANGED	pllpDhLLsohGsslGVslMCllpsGKtADccMc	......llKDhLLs.hGuhlGVslMClhpsuptADptMc......	0	4	7	7
+12501	PF12666	PrgI		PrgI family protein	Bateman A	agb	Jackhmmer:Q187G3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 116 and 146 amino acids in length. This protein is found in an operon that is part of a Type IV secretion system.	27.00	27.00	27.30	27.20	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.04	0.72	-3.84	74	644	2009-11-20 16:12:33	2009-11-20 16:12:33	2	2	377	0	81	480	60	93.20	27	64.99	CHANGED	pVPKDls+.hcsKlhhsL.ThRQLlshuhushlGlshahhh.+thl........u.........sshushlhlhshlP....hhhhuhachcG.hshEchltthlchc.lps+htsapo	..........VsKDls+.hcpKlhhsL.TpRQllhhssushl.u.ls.lahhh...pthh.................s.......sshuhhh...hl.hsslP....hhhhuhach..cG..hs....hEchlthhl+hc..hpscpRsat.................	0	46	65	75
+12502	PF12667	NigD		NigD-like protein	Bateman A	agb	JCSG target Q5LAY5_BACFN	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in Bacteroides species. Proteins in this family are typically between 234 and 260 amino acids in length. These proteins possess an N-terminal lipoprotein attachment site. The family includes NigD a protein found in the Nig operon that encodes a bacteriocin called nigrescin. It has been suggested that NigD may be the immunity protein for nigrescin (NigC) because it is directly downstream [1].	21.00	21.00	23.50	23.20	18.80	18.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.50	0.71	-4.51	55	331	2009-11-21 13:39:49	2009-11-21 13:39:49	2	1	107	19	39	282	1	190.80	20	78.62	CHANGED	hsTspssss...t.........htsDc..GsplhPsssss.........hssssupRshss..a....p.htpt.......sshshslplhtlpsllopsst.......hssp...p.p.thusDPltlhsh........Wh...s..ttYLslhaphphs..........sptppHhhsLlhsp.............tt.tsssshlpLpLRHs.....s.u..Ds.psthtp..u...........hlSasL.spl.sppttt.....ptlcl+hpsht.suctph.p	...............................................................s....ss...t.....hhthDc.us..pl..hPsssph............hpsspspRsls...a....s.hppt..........sshshslpl.ptlpsllotsht..........t.hssc...p.c.thusDPlplhsh...............Wl.....s..ssYLslhaphphs..........pptp+..HhlsLltsp.................t..spsshlpLpL+Hs......stu.....Ds.pshhtp..u...............hlSasL.spl..sptttt.....pslplphpsht.suc.p..th.............................	0	11	33	39
+12503	PF12668	DUF3791		Protein of unknown function (DUF3791)	Bateman A	agb	Jackhmmer:Q184Z5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 71 and 125 amino acids in length.	21.90	21.90	22.80	22.10	21.70	21.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.87	0.72	-4.36	45	302	2009-11-21 15:27:16	2009-11-21 15:27:16	2	4	144	0	37	238	2	61.40	24	67.45	CHANGED	lpFslh.....sIEshAcchshssp-shphhp.chsllc.aIhppY-sLHTput-all-Dlhchlcpps	................tahhh.....hIcphAcchslsspcshphhp.chs..llp.alhppY-sLHTpupcall--lhphlppp........	0	18	33	37
+12504	PF12669	P12		Virus attachment protein p12 family	Bateman A	agb	Jackhmmer:Q18C01	Family	This family of proteins are related to Virus attachment protein p12 from the African swine fever virus. The family appears to contain an N-terminal signal peptide followed by a short cysteine rich region. The cysteine rich region is extremely variable and it is possible that only the N-terminal region is homologous.	33.50	33.50	33.50	33.50	33.30	33.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.85	0.72	-3.77	134	610	2009-11-21 15:48:40	2009-11-21 15:48:40	2	2	570	0	65	310	5	50.80	31	79.85	CHANGED	slllslllhshsh.hh...l.hphh.+p.....p+p..G...........s.sC...u..C.........tssCtstt.......................................................pppc	......sIlI.shl.Ihuhsh..as..l.h+hh.K+..sKp...G........pCusCthsps.C............tCssp......................................pp......................	0	25	52	58
+12505	PF12670	DUF3792		Protein of unknown function (DUF3792)	Bateman A	agb	Jackhmmer:Q183N7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. These proteins are integral membrane proteins.	27.00	27.00	27.90	27.70	26.30	26.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.57	0.71	-4.23	64	372	2009-11-21 16:02:30	2009-11-21 16:02:30	2	1	364	0	85	268	3	115.70	27	90.89	CHANGED	sttphtsllpGllhuhhlohlhhllhulllhhss....lsEphhshhhhhlhhloshhGGhhuu++spp+GalhGhhsGllYhlllhlluhlhhss.hhs.hphhhphlhshsuGslGGhlG	........p..hspslhhGllhshllshlh.hlhu.LlLpaos....lsEsslshhlhllsllShhhuGhhuG++sppKGWlhGhhsGlhahlllhLlshlshsp.shs.sptllhhlhhhsuusLGGllG...................	0	42	70	76
+12506	PF12671	Amidase_6		Putative amidase domain	Bateman A	agb	Jackhmmer:Q18BM0	Domain	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.50	0.71	-4.18	83	491	2012-10-10 12:56:15	2009-11-21 16:27:14	2	11	364	0	128	483	20	158.20	30	49.09	CHANGED	tYspttAlp....YAc+assst.................Nss.......YtsF.........uuD...................CTNFlSQsL....puGGh...................................W...................ttss..........Ws.......supshhpYltps.thstthuttshpth.....................GDllpachs.uss.............................sHsslVoshsspshs........llssHTss....phphshs......hhtstphpathh	.................................................................YsRhpAVp....YAc+.ahsst....................................Nst.......YpsF................ssD...............................CTNFlSQsL.....cuGu.h.shsst...................................................W.............ppsthoh............u....Ws.......sA....cuhh.Yl...tss..tps..t...h.ht.tt..sht.p....t...................GDlItY-hp.scs.......th............................sHoslVsuh-spuhs...................LVssHoss......phph.as.....sh.p.ph.....h..........................................	0	61	107	112
+12507	PF12672	DUF3793		Protein of unknown function (DUF3793)	Bateman A	agb	Jackhmmer:Q18C06	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 211 amino acids in length. There are two conserved sequence motifs: PHE and LGYP.	22.80	22.80	39.80	39.30	21.00	19.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.12	0.71	-4.69	77	325	2009-11-21 16:43:30	2009-11-21 16:43:30	2	2	302	0	75	276	6	175.40	30	88.86	CHANGED	lshpC...APsLuGlKsusLhshs.................htstcplhphhp.hst.h...spslphhhLp..pspsphllhlY+pptLcphLpcppspphLpph..GY....pstslpphLppLppRh......ppst...............................FPHEIGlFLGYPlcDVtGFIppsGpshhhsGhWKVYss.pcuhphFppacps+pthhph.htpG.pslpplsss	........hhhpsAPsLsGlKsusLlshs.................hp.ptppl.t...phhp.apptht....tpslphhhLp..ps..ppphllhlY+cctLpphLpppcsppaLpph..GY......pstslpphLppLppRh..........ppp.p........................FPHEIGlFLGYPlcDVtGFIpppGpshhh.sGhWKVYss.pcApchFppYcps+phhhph.htpG.hsltplh..s..........	0	43	67	71
+12508	PF12673	DUF3794		Domain of unknown function (DUF3794)	Bateman A	agb	Jackhmmer:Q185X2	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF01476.	21.70	21.70	21.70	22.00	21.50	21.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.91	0.72	-3.83	173	709	2009-11-22 14:22:34	2009-11-22 14:22:34	2	10	223	0	199	603	18	88.90	18	45.01	CHANGED	sclt.cIlpspsp.lp..lpch.cl....hps..................................+lhlcGhlphpllYl................upcs....pp.......lpshp.tplsF..sphl-l.tusptsh.psp..lpspl-pl..ssslhss.c	................................................................plt.pllp.spsp.lp....lpch..cl......hps.............................................................KlhlcGhlphpll..Yh........................up-s..........pt...............lpshp..tplsFsphl-l...tusppsh..tsp.....hphp.lcp.h..phph....t..............................	0	122	177	188
+12509	PF12674	Zn_ribbon_2		Putative zinc ribbon domain	Bateman A	agb	Jackhmmer:Q18AK6	Domain	This domain appears to be a zinc binding DNA-binding domain.	21.30	21.30	22.00	22.00	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.36	0.72	-3.64	52	343	2009-11-22 14:37:54	2009-11-22 14:37:54	2	16	275	0	77	278	17	80.40	35	52.03	CHANGED	paCQSCGMPlspss...hGoptDGopsc-YCtYCYpcGpFst.phoh-EMI-hss.ahsctst.....hs.-pA+phhpphhPpLKRW+	.........aCQSCGMPhspss...hGoptDGopsc-YCtYCYcsGtFhp.phoh.-EMI-hsst..ahschst.....hst-pA+phhpphlPpLKRW+..................	0	35	59	70
+12510	PF12675	DUF3795		Protein of unknown function (DUF3795)	Bateman A	agb	Jackhmmer:Q186T2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 99 and 171 amino acids in length. This protein is likely to be zinc binding given the conserved cysteines.	22.60	22.60	23.90	23.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.92	0.72	-11.75	0.72	-3.80	72	322	2009-11-22 14:49:21	2009-11-22 14:49:21	2	10	173	0	78	292	7	73.50	32	51.97	CHANGED	hhuhCGlsCstCstahtsp...............................................Cs.GCtstpt.........htsttCp..ltpC..stc+.slspCucCsc..a.P.Cphhpp	...............huhCGlsCs.tC.ta.ttt.................................................Cs.GCtstph..........tsppCp..l+pC..sp..p.K..sl..saCscCsc.a.P...Cchh.t...................	0	46	75	78
+12511	PF12676	DUF3796		Protein of unknown function (DUF3796)	Bateman A	agb	Jackhmmer:Q185I0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	23.00	23.00	23.00	23.70	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.93	0.71	-3.88	13	204	2009-11-22 16:47:27	2009-11-22 16:47:27	2	1	179	0	17	150	2	106.10	38	77.59	CHANGED	ps+luYL.GFlGFlGF...LG.h.FhsppshFs.hhaFsFFsFFsa...uKl...lsDELFhpcV+tAsopAFhVullhssIlllhl...hlhcNlcl....Iclhl....sIshslsLsTFllsLhla-hppcc.hpD.......pp	...............s...hhhh.GFlGFhGF...LG...a..tt..hh...hFsFFuFFo.a......+pV.........ptDEhF.p.lsKu..sp.uFllsLhshhIlhhI.....hlhss.sL.......phpI....slhhusLIhsFuhshhha-+.........s..................................	0	6	10	12
+12512	PF12677	DUF3797		Domain of unknown function (DUF3797)	Bateman A	agb	Jackhmmer:Q18AB4	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. There is a conserved CGN sequence motif.	21.20	21.20	21.20	23.10	20.60	20.70	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.52	0.72	-4.34	9	99	2009-11-23 09:31:14	2009-11-23 09:31:14	2	2	89	0	3	54	0	53.50	77	43.88	CHANGED	M..pshcslpLhpK...YspCPpCGN-plGNGEGsL...l-DDpFKRTCKCGapIc	....MDLIIQTFPLDGKTLYYVQCPVCKNNRILNSGANVSRIISDDTFRKLCGCTCDVK.	0	1	2	2
+12513	PF12678	zf-rbx1		RING-H2 zinc finger	Coggill P	pcc	Wood V	Family	There are 8 cysteine/ histidine residues which are proposed to be the conserved residues involved in zinc binding. The protein, of which this domain is the conserved region, participates in diverse functions relevant to chromosome metabolism and cell cycle control [1].	30.60	29.80	30.60	29.80	30.50	29.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.22	0.72	-3.87	110	903	2012-10-03 15:03:13	2009-11-23 17:28:56	2	21	332	18	628	6919	344	76.70	40	28.82	CHANGED	+hplp.....c...apuVuhW.p.....Wshs....................-..........s..CuICRsph..ssC.....pCphss.................--...Csl..sh...Gt.CsHsFHhHCI..........pcWL..c..pps.......hCPlCp	.........................................................................................htl+.c.WsuVuhW..s....WDl..........................................s.D..........s.....C.AICRscl...h-..hC...l...cC.pusptt............................................................t--....Csl...........sa...G...C.....s............H.s......FHh.cC.l..........ppWL....+....ppp..........sCPLsp...............................................	0	233	348	516
+12514	PF12679	ABC2_membrane_2		ABC-2 family transporter protein	Bateman A	agb	Jackhmmer:Q189I9	Domain	This family is related to the ABC-2 membrane transporter family [1].	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.86	0.70	-5.54	35	2420	2012-10-03 10:13:34	2009-11-24 09:49:33	2	14	1493	0	891	9805	1242	277.90	14	89.44	CHANGED	hslhcpEapchl+s+phhllsllhhll.....................................hhhshhsphssthhsshtsstpshssh.hh.........................................................................................................hhthllslh........uhlhusshlutEhcpGTlchLLupPloRtpllluKhluthsh....lllshlluhll................................shshhhhhusshshtshhhhhhhshhhhhhh.......hululhlS.slh+..osstAhssululhhhhtllhshhshh......l..h..........................................................h.hl.Ptshhphhhpthhtst................................................................................h..ht.hlhhllhhllhlsluh....hhFp+cDl	.............................................................................................................................................................................................................................................................................h..lhtpEhh.p.h..h...p...p...h...h..h......h....h..h.h....h...l.h.hhh............................................................................................................hh.h.h..h....h.......t..h.........s............h...............t....................t......h...........t....h................h....h............................................................................................................................................................................................................................................................................................................................hhh.h.l..h..s..l.h............s.h..h...l..u.......h.....s....h.....l......u......t....E....h..c.p..G.T.lc....h..L....L.s.p.P.l.oR.s..pl.lh...u....K....h..luh..h..h.h...............hh..l.s.h..l.h..u..hhh...............................................................s.h.h...h....h....h......h.......h....s.....s........s.......h.......s......h.....h......t....h......h....h.......h.......h......h....h...h....h...h...h....h..hhh..............h...h.u....l...u...h.....h..l.S...s..h....s..p......p....p....t..h....A..h..s...h....u....l..s.l.....h....h....h......h......h.....l...l..h..s..h....h...h....h.h..........h.......h.............................................................................................................................................................h...h...........h...s....h....h...p..h....h............t...h...h..t.s...............................................................................................................h...........h....h.h....h....h...h.h..h....h....l...h.h.h.lsh.......hhFt+t..............................................................................................................................................................................................................................................	0	334	627	821
+12515	PF12680	SnoaL_2		SnoaL-like domain	Bateman A, Finn RD	agb	Jackhmmer:Q11X43	Domain	This family contains a large number of proteins that share the SnoaL fold.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-10.33	0.72	-3.61	623	6223	2012-10-03 02:27:24	2009-11-24 16:13:34	2	57	1993	66	2137	7931	2945	104.20	15	64.43	CHANGED	l.pp...a.h.c....s.h.s......st...-...h....c....s.h....t........sh....h....u....sD.h.h...h....p.........ss.....sst...........hp.Gtp.....shtp........hhpthht.................hsshphp.lp.ph..........hss..G....c.........tlss..p.....hphph...........................sup.thph.................pshs..h..acl...c...c.G...+..Isch	...............................................ta.h.p....s.h..p........st...D....h.....c.....t.h....t........sh....h....s....sD..sh.....hp..............ps.....sst......................hp.Gp.p.....sltp.......hh.tphh.t........................th.s.s.h..p..h.p...h..p.ph............hss....G.....s.....................hs...hs...p......h.pht..........................................s.up.th.ph.................phhs...h..h.ph....c...s.G...+Ist.........................................................................	0	618	1329	1765
+12516	PF12681	Glyoxalase_2		Glyoxalase-like domain	Bateman A	agb	Jackhmmer:Q187Q5	Domain	This domain is related to the Glyoxalase domain Pfam:PF00903.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.39	0.72	-3.44	429	20226	2012-10-02 15:00:03	2009-11-24 17:23:30	2	76	3531	174	6614	23813	5121	112.40	17	76.73	CHANGED	lhs..p..D..hpt..utpFYpph.l......Gh..p...htt...................pt...s....p..h......sh...h.ph......s................h..h.............................................t....h..tt.hh.....t......h..t...........................t...t.....ss..........ts........st........h..tl.....t..h.pl.......s.-....l..-s..h...hp...pltst.................G......sph..............h..p....s...s..t.......p...........hsh..............s........p...hhh..l..tDP...-Gshlplh	.....................................................................................................................spD..hpp.u...h.pFY..p...ph...l.........G.h...phtt......................pt.s....s..h........sh..h..ph......s...........t.h..........................................................................................................................t...h...t...hh....t.......t..............................t...st....ss........ss..............st................hp.l............s.h.ts.............s..-...........l....-...s...h....hp.....c...l....tst..........................G.....sph..............................h..p....s...s..t.........p.............tsh...................................u...........p.......hh.h..h...tDP...-Gphlpl................................................................	0	2073	4288	5609
+12517	PF12682	Flavodoxin_4		Flavodoxin	Mistry J	jm14	Manual	Domain	This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.05	0.71	-4.87	5	1133	2012-10-03 05:08:30	2009-11-25 13:20:28	2	15	627	3	273	1382	49	149.40	28	80.50	CHANGED	KsLVAYFSso.....................GNTKhlAEhIAEtTGADLFEIcPscPYTctDLDas-ptSRSSVEMpDspuRPAluscl.shEDYDVlFlGFPlWWYsAPpIVsTFlEuYDFuGKpVIPFCTSGGSGlGsotKcLQ.pAsPcAolLEGptlsRGpl.......oRcpVs-Wlc+L	................................................................+hLlsYaSto.............................................G.sTctlAc.....hI.s......c......t.....h.......s.....u.......D......l.....h....c..I.p.....s...t...p...s...Y..s..p..............s.......a.p......s.t......h.......pp......u..p..t..............E.......h.....p..p..........s.t+..P..t....l.....p....s..p.....h.......s..h.sp....Y.......DslalGaPlW.at....p.hsh....sltoF...L....c...p....h.......-.......h.............s...G.K...pl..h....PF.s.T...p...u....G...o...u....hu..p.......s....h....pp.l...p....p.h.........t.....s.....s..s..p....h.h..p.Ghh..h.....t..s.t.....................t..t...lttWlt...........................................................	0	90	199	240
+12518	PF12683	DUF3798		Protein of unknown function (DUF3798)	Bateman A	agb	Jackhmmer:Q183D5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 247 and 417 amino acids in length. Most of the proteins in this family have an N-terminal lipoprotein attachment site. These proteins have distant similarity to periplasmic ligand binding families such as Pfam:PF02608, which suggests that this family have a similar role.	21.00	21.00	21.80	34.00	20.70	20.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.40	0.70	-5.31	16	148	2009-11-26 10:12:10	2009-11-26 10:12:10	2	1	90	2	26	138	5	260.70	50	68.55	CHANGED	ssa+IGllTuTlSQuEDpaRuA-thhccYGs................hIhpsTaPDNFssEhETTISplluLA-DPchKAIllspuhsGshsAhpKI+EcRPDIlhluusspE.......DsshhupsuDlshssD.lspGhslsptApchGAKsFlHhSFPRHhu.hpslupR+shMccsCc-LGlcFl-sssPDPsoDsGsuusQQFlhEclPchlcKY.GK-TAaFuTNsuhpEPll+plhEtGuhasptssPSPhhuYPuALGl-lstsctGDastlhcplpcKlsctGhsGRhG	.....................................saHIGllTsoVSQSEDshRGAEtllc..cYGsssp...........GGhIpplThPDNFMpE.pETTISplluLADDPpMKAIVVspulPGTstAF+cI+EK..RPDILlhsupsHE.......DPshlsssADlsls..sDtluRGYlIltsA+chGAcpFlHISFPRHhS.YEhlu+RRsIMcpsCc.DLGhcalt.oAPDPsSDVGVsGAQQFILEpVPpWlpKY.GK-sAFFsTNDApTEPLLKplst.h.GGhFlEA-hPSPhMGYPGALGl-ho.c-tGsastILc+VEcsVlttGGsGRhG...........	0	17	25	26
+12519	PF12684	DUF3799		PDDEXK-like domain of unknown function (DUF3799)	Bateman A	agb	Jackhmmer:JCSG target 392282	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 265 and 420 amino acids in length. It appears that these proteins are distantly related to the PDDEXK superfamily and so these domains are likely to be nucleases. This family has a C-terminal cysteine cluster similar to that found in Pfam:PF01930.	21.10	21.10	21.20	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.58	0.70	-5.02	19	347	2012-10-11 20:44:46	2009-11-26 15:13:40	2	3	303	2	52	350	410	226.40	26	57.25	CHANGED	cYhSsSpaKpF......hp....CEAtAhApLpGcWp......ppsssALLVGNYVHS.YFES.csc-pFhc.......pcschhoph.....pKGpL+u-FphA-pMIpsLcsDchFtphYp.G......-KElIlTG-lhGl.WKuKlDslNhpcshFl.DLKTsc.sl+.pchWsp..t......ssFlctasY.lQhAlYpEl..lcQ....phG.cphpPhIhAVoKpssPD+sllplsp....phhctuLcplc.pslp+lhpVhpGc.cPs+CG+C-YCRus	..................................................................................................................................................hShS.hcph......h.p......s.A.hhhhc..h....pu...hp.......ppcsps.L.lGshhHs....h.h.Espc......hpp.cFhh............tppp.chh.ppst..........ppshh.tc....-.h...c..t.h...-hMh...ps..l..ht..pshh..p.....h..l..hp...G...................Epp..l..h..h..p..sp.....s.G...l..h....h+s+.Dp.l.....s.......-.......h..p....h....h.....h.D.lK..TTt..D..lp..................pa.....tshh.satYclQhAhYp-h..hct......ph..G..p......t.h.p.h..l..h.lul.Sc.p..h............shplhhhsp......-th..t..pp.....hc.pslpplhcshpsc.p.P..............................................................................................................	0	20	40	44
+12520	PF12685	SpoIIIAH		SpoIIIAH-like protein	Bateman A	agb	Jackhmmer:Q18B63	Family	Stage III sporulation protein AH (SpoIIIAH) is a protein that is involved in forespore engulfment. It forms a channel with SpoIIIAH that is open on the forespore end and closed (or gated) on the mother cell end. This allows sigma-E-directed gene expression in the mother-cell compartment of the sporangium to trigger the activation of sigma-G forespore-specific gene expression by a pathway of intercellular signaling.  This family of proteins is found in bacteria, archaea and eukaryotes and so must have a wider function that in sporulation.  Proteins in this family are typically between 174 and 223 amino acids in length.	25.80	25.80	25.90	25.90	25.50	25.70	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-10.92	0.71	-4.81	84	427	2009-11-26 16:59:55	2009-11-26 16:59:55	2	2	414	3	98	318	4	186.60	23	93.45	CHANGED	+pthllssLslhls...luuY...................hsYths...tsttpspsttpptp..t.t.............................................................................................................................................ssspsspsssssspsspph.....................Fsph+lpREppRucph-pLppIlsssssop-pKpcAhpphhplsphtcpEttlEsllcuK.GapDulVhlsss.p..lsVlVpspp..LocscsspIt-lVpcp.sslssppltlp	......................................................pp.hllshLslhlslu..sY.....................Yhhs..p..t...sssssts.sp....t...tttt..p......t......................................................................................s...................................spppspppssssspsssph..........................Fsph+hphEppRucphppLppllsss.ssotppKscAtcphttlsphpppEttl.EsllKup.GapDulVphss......s..p.lpVsVpusc...hoppcsspIhplVpppss..t..pl.l...................................	0	48	79	87
+12521	PF12686	DUF3800		Protein of unknown function (DUF3800)	Bateman A	agb	Jackhmmer:Q183E5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 215 and 302 amino acids in length. There is a DE motif at the N-terminus and a QXXD motif at the C-terminus that may be functionally important.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.38	0.70	-4.72	127	700	2009-11-26 17:12:18	2009-11-26 17:12:18	2	2	610	0	183	611	68	214.40	13	82.60	CHANGED	hla.....lDESGshsh...............spshasluulhhppppht..phtppht.phppchhhtt................................................................l+tscltpp...ptt.....................................pplhshltpht...............hhhhs..hlhppthhppt...........htttt...............aphhhphllcclt........................................ppsp.....phtlhhD.....pppppptppltphh..................................htthtppthhpph..lpthhhhcScp...t.....thlQlADhlss....sltpthph...............................................................pptppphhphl...cptht	......................................................................................hahDESGphs..................tp.has..luu.l.hh..t.pp..hh....ph.p.ht...phppphhh.t.................................................................................................l+hsph.pp.....tht......h.................................................................................................................pthhphhtp..........................hhhhhhhh.ppp.httt..................................tt..................aphhhp.hhlppl...................................................................tptp........phh.l.h..hD........pppptpt.p.p.l..hthh.......................................h.ttthhtth...h..p....hhhhpScp........p.......hlQlADhlss......sltphhp................................................................th.................................................................................................................................................................	0	71	127	162
+12522	PF12687	DUF3801		Protein of unknown function (DUF3801)	Bateman A	agb	Jackhmmer:Q187F8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 158 and 187 amino acids in length. This family includes the PcfB protein.	22.80	22.80	23.00	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.32	0.71	-4.75	54	614	2009-11-27 16:03:44	2009-11-27 16:03:44	2	1	330	0	47	447	58	155.40	25	85.15	CHANGED	u+hLttultthLpchcKpp..................................GKpol+pLhcp.stslpslclscp..slKpFc+hAKKYGlcaulhKDpsssss..pa.VaF+ucDs-slstAFccastcplppp..................................................................................................................................................................................................................................................c+PSl+ppLpph+.tptttp.....................php+....pps+pKc+	..............................................p.l..hhtthht..ph....pcttt...............................tGc....plKcLh+.c..up..LpsIplscs...slKchc+phcKaGVsFulhKD+psp......pY.lFFpu+Dhcsh....ptAFcc.hhsc.phc+pcc..............tphpc.hp..................................t................................................................................................................................................................................................................................................................................................ppp............................................................................................................	0	30	38	42
+12523	PF12688	TPR_5		Tetratrico peptide repeat	Coggill P	pcc	pdb_3kni	Family	BH0479 of Bacillus halodurans is a hypothetical protein which contains a tetratrico peptide repeat (TPR) structural motif. The TPR motif is often involved in mediating protein-protein interactions.  This protein is likely to function as a dimer. The first 48 amino acids are not present in the clone construct. This Pfam entry includes tetratricopeptide-like repeats not detected by the Pfam:PF00515, Pfam:PF07719, Pfam:PF07720 and Pfam:PF07221 models.	21.40	13.60	21.40	13.60	21.30	13.50	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.62	0.71	-4.07	8	427	2012-10-11 20:01:02	2009-11-30 13:29:35	2	50	408	0	96	763	182	114.00	31	46.94	CHANGED	upAhFERAGAhDSsG+pscAlPLYRcALAsGLsGspRRRAsIQLASSLRNLGcs-EuLALLpsphsthPuDELssAlsuFhALsLsutGRscEAluhlLtAlAsHLP.....RYQRShpsYAptL	.................................................h.a.hA.haDshGh.E.pcAlshY..cp.....A...l.......s.......t......s....L...s.....u...c.....p...h...p...t.....A.h..l.....s......L..u...SohR.sl.......Gp.h-pAlslL...p.s.....s...l...t....c....a.....P.....s.......................s.s....s......h..c..s.F..h...u...h..sLa..s..l.uc..pc..E...Alphh..Lthl.....s.....pps...................ap+ult.Ytt.L..........................................................	2	34	69	88
+12524	PF12689	Acid_PPase		Acid Phosphatase	Mistry J, Wood V	jm14	Manual	Family	This family contains phosphatase enzymes and other proteins of the HAD superfamily.  It includes MDP-1 which is a eukaryotic magnesium-dependent acid phosphatase [1-2].	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.08	0.71	-4.62	43	326	2012-10-03 04:19:28	2009-11-30 15:33:38	2	10	244	6	217	336	18	152.80	32	75.86	CHANGED	.lP+LlVFDLDYTLWPhasDs+..................lssPh+tpsss.........plh........DctGpplphYscspsILt.......tLcs.........+ulplAhASRTssP...clAcphLphLcls................th.hhchF....st.lEIas....G..oKspHFp+lpc......coGl..sapcMlFFDDEpRNhpshop.LGVshhhl..ss...GlohphhccGLppapcp	......................................hP+lhVFDLDaTLWshas-sc.........................................htsPh+..tss....................thh..............................Dp..tup..ph.phascl.tlLp..tLcp.........pul..luhASRT..sts...-hApphLch.hcl.......................................phF.....sh....hpI.as......u......sKhpH....Fpplpp........................poul...a..pp.M....lFFDDEtR....N.........hps...p..............lGVs.........h.........hhl..s...Ghshp.hppGl.tatt.t.............................................................................	0	68	123	176
+12525	PF12690	BsuPI		Intracellular proteinase inhibitor	Mistry J	jm14	jcsg_3isy	Domain	This is a bacterial domain which has been named BsuPI in Bacillus subtilis.\	     This domain is found in Swiss:P39804, where it has been suggested to regulate the major intracellular proteinase (ISP-1) activity in vivo [1].  The structure of proteins in this family adopt a beta barrel topology.	27.00	27.00	28.20	27.10	23.40	20.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.68	0.72	-4.27	39	149	2012-10-03 16:25:20	2009-12-03 15:47:41	2	11	122	1	58	124	3	82.90	27	39.88	CHANGED	slphplslpNpsscslslpFsSGQcaDlhlh...........DppGcclacaScs+hFTQAlpphslpsG-shsap.tphs.ts........sGsY.plps	..................s.lphpholpNpsspslslpasSGQ+aDhhlh...........spcscclapaS..cs+hFsQshp...spslpsG-ohsap.tphstts.........stY.h.................	0	23	39	49
+12526	PF12691	Minor_capsid_3		Minor capsid protein from bacteriophage	Coggill P	pcc	manual	Family	This family is from one of three adjacent genes, all of which are involved in formation of the minor phage capsid.	20.40	20.40	22.40	23.90	19.20	18.50	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.63	0.71	-4.47	14	101	2009-12-03 17:53:01	2009-12-03 17:53:01	2	1	99	0	8	73	1	131.10	31	98.94	CHANGED	M.....DhhphLtshlps..hthPhKschshl.spp-........ululh.lPuup..sppYh-GscplshpaplshKocsp.cAppsl.tIsstLspl.thc......l.ShssSapacshslhspPthsctsspGhalYhhshssclpl...ttp	......................M....DFhssLhptIcs....thsh.....ch+hshl.spp-........slslh.hPuuc..ppcYhDGsp-hShsFplshK.oK.....sptpupsslatIsshLsph....s......L.StssSapapsh-l.spPhlssts-pGhalYslshps+l.l.c.t..p..............................	0	3	6	8
+12527	PF12692	Methyltransf_17		S-adenosyl-L-methionine methyltransferase	Mistry J	jm14	jcsg_3iht	Domain	This domain is found in bacterial proteins.  The structure of the proteins in this family suggest that they function as a methyltransferase.	18.10	18.10	18.10	18.20	18.00	17.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.94	0.71	-4.55	18	51	2012-10-10 17:06:42	2009-12-07 14:19:28	2	1	41	2	19	80	17	158.40	46	96.81	CHANGED	MSRLDSFIRRhoAQRDsLNaAsspsusls.GsVLELGLGNGRTYcHLREhhPsRRIhVFDRslsuHPsSsPP--shllG-lccTLst.ltthGssAuLsHADlGsGsc-KDsspAshlSPlIAslLAsGGlhVSupPLh.a.uLpplslP-ulssGRYFhYRR	.................MSRLDpFIcRhoAQRDhLsasts.......pl.ssh.s...Gs.V.hElGLGNGRTYcHLREhhPsRcIhVFDR.s.ltuHP........uS..sPsp-c..h.lhG-.lc-TLss.h.thGssAuLsHADlGsG.c-+DsspushLuPLlsslLAsGGlhVSupPL..assLptlPlP-ulstGRYFhYR+...................................................................	1	2	11	12
+12528	PF12693	GspL_C		GspL periplasmic domain	Bateman A	agb	Bateman A	Domain	This domain is the periplasmic domain of the GspL/EpsL family proteins. These proteins are involved in type II secretion systems.	24.10	24.10	24.10	24.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.83	0.71	-4.47	23	933	2012-10-02 17:03:51	2009-12-07 17:13:58	2	6	819	2	175	737	69	154.50	24	39.73	CHANGED	pppht.W..RhlshhhulhLllhlsttshphaphtppupthptpuppla....pphFPsppplhs....ptQhpppLpph...tutssssshlshLutLtshls..sssslclpuLcacupctcl+l..plpusshsth-......phpppsupt.aplp......uphpppssplpuphslc..s..p	..................hthW....Rhshhshhlhlls....h....sstpslphap.lp...ppssthcsp...spcha....pphF..Pppp+..ls..s...h+pQhpppLpph.......pstsss......s.ph...lshL...stlsssLt......ph.s.s.lp..l...puhsacppctpLpL......phpu...tshssh-......phpptLspp..a...lp........sth.ppps.-.sVpGthsl+..p......................................................	0	38	86	133
+12529	PF12694	MoCo_carrier		Putative molybdenum carrier	Mistry J	jm14	jcsg_3imk	Family	The structure of proteins in this family contain central beta strands with flanking alpha helices.  The structure is similar to that of a molybdenum cofactor carrier protein.	23.10	23.10	23.30	25.30	22.40	23.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.80	0.71	-4.75	28	67	2012-10-01 21:16:48	2009-12-08 13:32:46	2	3	58	1	34	73	15	137.60	41	76.45	CHANGED	IlSGGQTGVDRAALDsAlstGlspGGWCP+GRpAEDGslPs+Y..LpETssssYttRTchNVpDSDGTLIls.pGcLsGGTthThchAcctsKP.....hLll...phspsps..sptltpWltppslplLNVAGPRESpsPGIaptspshLppllp	............IlSGGQTGsDRAALDhAlt..hsl..shGGWCPpGRhAEDG.lss...cY.......LpEhss.ssYt........tRTchNVhDSDuTLIls......tu.t..LsGGo...thThphApchtKP.....hLhl..........phst...tps...sttltpWltppplplLNVAGPRpSpsPuIhphshphLpthh.t............	0	17	28	32
+12530	PF12695	Abhydrolase_5		Alpha/beta hydrolase family	Bateman A	agb	Jackhmmer:Q186B9_CLOD6	Domain	This family contains a diverse range of alpha/beta hydrolase enzymes.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-11.17	0.71	-4.44	308	16512	2012-10-03 11:45:05	2009-12-10 17:24:36	2	168	4213	56	5692	81995	21732	192.90	14	59.02	CHANGED	sllhh.....HG....s...........ss.....s...t..p.....s....h.......t....h.u...p.......tL.spp.G.hsllhh..................................ch..s...t.t...ss......s...........tsts......................phpphhpt....................................................................hh..........shp...pl...hlhGcSh.Gut.suh...hhAs...................................................................................p...p...t.....pl.p..ull....hh.u..s....................a...........................ss........hp........plt......p.hph..........................................................PlLllt...Gsp...Dphs.......s...p.ph..pp.........................................................hhpt..hs....sst.....p.h..........................................hhl.p.Gu.sHs	.......................................................................................................................................................................................................llhh...H..G.......h...................ss...........s.......t....t...........t........h............................t.......h....u....p........................tl.....s....p........t.....G.......h.......s..........l...l.h.h.........................................................-h....t...s...h...ut.......s...................tst.........................................................sht..t.hlp..h.....................................................................................................................................tths.......s.p..p.l....s..l..h....G.......t..S.h..G.u.t....h..u.h.....t..h..us......................................................................................................................................................................................................................................................................p.p....t......pl...p.....u.l...l........h..h.u..s.......................a..................................................................sp.......t...........t.ht........t....th......................................................................................................................................................................................................Ph.L..l..l...p........G..p.p.......D..p.hs............sh.....p...t...s....t.p................................................................................................h.h.p..t....ht...........t.h.......p..h.....................................................................h..h..h......s.stH........................................................................................................................................................................................................................................................	0	1991	3619	4800
+12531	PF12696	TraG-D_C		TraM recognition site of TraD and TraG	Coggill P	pcc	Pfam-B_1146 (release 5.4)	Family	This family includes both TraG and TraD as well as VirD4 proteins. TraG is essential for DNA transfer in bacterial conjugation.  These proteins are thought to mediate interactions between the DNA-processing (Dtr) and the mating pair formation (Mpf) systems [1]. This domain interacts with the relaxosome component TraM via the latter's tetramerisation domain. TraD is a hexameric ring ATPase that forms the cytoplasmic face of the conjugative pore [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.59	0.71	-4.27	232	1419	2012-10-05 12:31:09	2009-12-11 11:56:10	2	13	918	0	310	4110	322	119.20	22	19.22	CHANGED	tlhhlLDEhuslspl.sphpphluhhtutGlphhhlhQshuQlcp...hYG..c...ptt..cslh.uNsss....pl.hhs.....ss..-.....pTschlSc.hlG....ppol..tp.tpptpt............t.....p..........p+sLlsssEltplsp	.........................h.hhlDEhssl....h..h.....h......p.....t.....h....tp.....hls.........put.......uttltls.lhhQsh.uQlct......paG....c.....tps....pplh.sNs.sshl..hht....sp...ss..pTAchl..oc..th.G...ch..phtp..pohststps......................................psphphttp.llsssclhsh.......................................................................................................................................................................	0	90	215	280
+12532	PF12697	Abhydrolase_6		Alpha/beta hydrolase family	Bateman A	agb	Jackhmmer:Q186D8_CLOD6	Domain	This family contains alpha/beta hydrolase enzymes of diverse specificity.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.69	0.70	-4.48	785	53202	2012-10-03 11:45:05	2009-12-14 16:32:03	2	430	5271	368	19769	83722	24117	238.80	14	74.29	CHANGED	l.l.l.l........H..G....h...........s....s..ss................t.t....ap..t............l.h...p...tL..s............p.....s...........a............p.........l...............hs...h.....-...h.........G.....t...G.....t......o.......s.....................................................t.....t........................................h.s....h....................t...p.h............sp................................s.l........................................t.t........h....l.....p.....p......h.sh............................p....p.....s....................................................h...l..l..GaS.h.G.u.......h.h...s.ht....h.s.......................tp.....t...s..p.............tl..ps..........l..l....hhs....ss.s...........................................................................................................................t..........t.hhp..............thh...............tth.t.........h.....tth............t......t.t.......hht..h....h...................ttpth............p..phh....................................pt........................tht.th..hp.hhtt........................................................................tttth...t....pt.h...sp........h........s.........h.P....s......hh..l.....h.....upp.Dp..............................h.h.....s..............p.th........................pph...t....p..t...h.....s..s.........s.........p...h...h......h..l.s.....t..u.u.Hh....h...h.h...p...p.....s...p.t...l...sph	...........................................................................................................................................................................................................llhl.H...G.....h................s........s.st...............t......ap..t............................h.h.....t...tL..s.......................p.....s...................................a................................p...............l...........................l.s.....h...................D........h...................h....G.............h.....G...........t............S.......s................................................................................................................................................................................................t.........................................................h..s....h....................................................p...p...h...........................s.p...................................................................s...l................................................................................................................................................t..t.......l.....l.......c....p......hsh...........................................p..p...h........................................................................................................h...l....l...G.a...S..h.....G...G............h.l.....u...h.t.....h.u.........................................................................tp.......h..P.p..................................pl..p.s.......................l......l.......lhs......ss.s....................................................................................................................................................................................................................................................................................t.h.h.t.........thh.........................t..h......t..............h..............tth.......................t....t.......hh...t......h.h...........................t.t...t..h.............t.t.h.h..............................................................................pt..........................................t.t.h.h.t.hh................................................................................................................................ht.tsh....h.........t..t..h.....tp............l............p...............h.P......s...............ll...l.......h..................G..p..p...D...........................................................................................................h.hs..................p.hh...............................................pt.h.......t........p...h......h......s.....p...........................s.........................p....h........h.........h...h............................t...s..u.Hh..........h...p.......t......t...h...h........................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	5860	12066	16584
+12533	PF12698	ABC2_membrane_3		ABC-2 family transporter protein	Bateman A	agb	Jackhmmer:Q17ZU3_CLOD6	Family	This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].	31.60	31.60	31.60	31.60	31.50	31.50	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.58	0.70	-5.41	220	16168	2012-10-03 10:13:34	2009-12-15 10:08:38	2	60	3863	3	4148	18062	2565	336.20	12	63.90	CHANGED	+t.h....l..h.tll..h..P...ll.h.h..h...l.hs.......hh..h....h....htht....p..............pshpl.................sl.lsps......................hspp....hh......................................................ptlp........s...p..s..p......hp....................thss....hp.psp..pt.l....ps.t.......p.hp..u.hh.h.......l.spshttth................................................................................................t...phphhh....ssps.h.....pts............................................ttltpt..lp..............................................................................p...l........hpt...................................h..pthshsh..p..h.hsh.................t.ptt.....p..sh....tt.......h.............hhs......hl...h..hhh....hhhs...sh....h..h.sh.......t....l....s....pE..+p.s.ph.h.c...hhh...so..l....shhp.......hhhu+.......h....lshhlh...th...h....h......h..l.h.h......h.......l.......h...hu..................................................lshs.....sh...........h.h...h........l.....lhh.llh.hh...shss..........luhhl....utl....h.p...st.......tp..s.......hh...hshhhh...........h.h.hsh....hh.sh...h..h.......h.s..t.........s...........sh......h..t.h....l.....hp.hl..P.hhs.hhhh..h..hp.l.h................hss.....hp............................................lh.....hslhhl.h...lh...sll....hhh...lshh	..........................................................................................................................................................................................................................................................................................................................................................................................................................................................h.........h..hs..hh.h......h...h...................h.h.............................................................tth..h............................sl..hs.p........................................stt...hh......................................................................................................................................................................pt.ht.............t.................ht.........................h.s.....t.pht.......tt..h......................pp.t............p..h......h...hl...............................h..s.sht.tth.............................................................................................................................................................................................................................................................................h.t.hhh.....stt.........h.....................................................h.th......lp................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.....h........ht................................................................t.........hph...p....h.h..............................................hs.t.......th.....t.............h............................hhs........hh.....h..hhh....hh.hs.....sh......h....h.sh..............l..............s.....pE....+....p..p....t...h...h..c...............hh.h................s.s..s...l.....s......hp............h.h...hu+..........h.......ls....hh..h..l.......sh.......lt.......h...........h...l...h.h.....h.......l..........h..hs.......................................................................lsht.......s.................h...h......h...........h.......hhh....hlh..hh....s.hhs...................huh...h...l.......us.h........h.p...s.................tt..s.............h..hh.......hhhhhh.................................h.hh.h........hu..sh.......h.s..............h.p..t...............h.s...................................th..........h...p..h................l............................t.........hh....P..hth..h.h.ph.....h...tph..h............................htt........p.........................................................................................................................hh.......thh.hl..h...hh..sh.h.hhh.h...h....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1433	2455	3318
+12534	PF12699	phiKZ_IP		phiKZ-like phage internal head proteins	Hardies SC, Coggill P	pcc	Hardies SC	Family	Phage internal head proteins (IP) are proteins that are encoded by a bacteriophage and assembled into the mature virion inside the capsid head.  The most analogous characterised IP proteins are those of bacteriophage T4, which are known to be proteolytically processed during phage maturation, and then subsequently injected into the host cell during infection. The phiKZ_IP family consists of internal head proteins encoded by phiKZ-like phages.  Each phage encodes three to six members of this family [1].  Members of the family reside in the head [2] and are cleaved during phage maturation to separate an N-terminal propeptide from a C-terminal domain.  The C-terminal domain remains in the mature capsid.  The N-terminal propeptide domain is either mostly or completely removed from the mature capsid. In one case, an unrelated polypeptide is embedded in the propeptide and also remains in the mature capsid.  The phiKZ-like IP proteins are not discernibly homologous to the T4 IP proteins, and it is not known if the phiKZ-like IP proteins are injected into the host cell, or have some other function within the head. The alignment and HMM model exclude most of the propeptide region, but include the cleavage sites.  The first 100 residues, including the cleavage sites, constitute the most conservative part of the seed alignment.	22.30	22.30	22.30	22.60	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	339	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.87	0.70	-5.52	14	27	2010-01-13 14:45:13	2009-12-15 10:40:50	2	2	9	0	0	28	0	299.70	13	68.77	CHANGED	tus.tho........ppstpshhssLEslsppl.thcthshu..hEsasss.pst.tthh.....slE..............slpctlppsscphhchlp+lhphlpphhsphpsulpplpc+hspLhc+hpsh..........tp.s.tpplslp.s..pclhhsGpFl..............shhhhsh.phsshhsptasp.hhshlpphschlsshphscp.hsphppthphhsc....................................htstthhhpustlsGNptlhhssspht.s..................hpa..lpsputsss-........hsl-s.sssp.lppplctlpphlptlpchppttpchp........-plcphh-shpp.sth..scps......hcshp-sstclhcsstshlpshssplsshl	..........................................t....ths.pththh.sshcphptph...pthshu.......hEshs.ss.p....th......sh-..............slppthpphhcchhchlpplhshlpphhpphtsuhpplpc+hspLhpchpph..............................tp.s.tpphplt.s..thlhhsupah.................hhs..phsp.htpshsp.hhphhpphtthhpsh.hppp.h.sthtphhphhtt.........................................hh.ts..lsGNthlhhs..tsthh..........................ttpt..st.p........hplch.sstp.ltphlptlpt......hh....phhtthpthpppht........ctlpp.hhpthtt.ttt..spt.......hphhtps.tchhps..thht.ht..ht............................................................................................................................	0	0	0	0
+12535	PF12700	HlyD_2		HlyD family secretion protein	Bateman A	agb	Jackhmmer:Q182V7_CLOD6	Family	This family is related to Pfam:PF00529.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.97	0.70	-5.28	70	15970	2012-10-02 20:27:15	2009-12-15 12:46:01	2	62	3553	31	4798	25329	5154	298.90	18	77.75	CHANGED	plppsslt..pshshsGhl.......l..+.pEphlpuptsGhl...phhlp-Gp+VppGshlhslsssphtpphhpt.tt.t.....hpphp....................................t.h..................h..thppp.apthht.ppphpthh.phpp.ptt...........................tthptphp...................................................lpushsGlls...hDuhEth......................t.hp.....................ppp..hpss....stlpsusslh+llss.pp........hplsh.l..s.....ccphpplp......p....sps..l...................plphts.spshpup..lp.ltpt......sp....t.hshlphsst.htchhspRhlclplhhpp.psGLpIPpoAlspcs..........................................................................................................stpGVYsl.ppu..hspF+plc.....lltp..sccahlV.................tpG.Ls.hDplll	....................................................................................................................................................................h............h.h.G..p.l...................t.....s...p.p...s...t...l...s.....s...p.....s....s........G........p....l.......tpl.........h........l.......p..............G..pp.......V.......c.p.G.p.h.L.s.....p...l...c...s.......s...p.......h....p....t....t.....h....p......p......s...p...u...t....h...t...t.......p.t...t...h..tp.h.p........................................................................................................................................................................................................................................................................................................................................hp..h.....t.....c.........p.....p...l.....h.......p.......p........t..........h.......h.......s.......p.......p.....p.......h.....c.......p.......s..p...s..p..h..p.t.spsph.........................................................................t..p...th.tp..............................................................................................................................................................................................................................................................................................lp.A.P.h.s...G.....h...ls....................................................................................................................................tht.....s.p....G............ph....l.......s......s........u.......p..........s.........l......h....p...l.....s...s...h....ss..................................h.hl.p...h...p...l......s...................Ep..p....l....s..p....l..p...........................h..................Gp.p...h........l.....................................................................p..h....t...s......h......s..........s.....p......p....h......p...up........lp.t..lsstss................................tst..........s.h..t..s...p...h.....p.........l............s.........s............s.......s........t..........t.............l.........h.......s..........G.....h.......h......s.......p.....s.........p.......l..................h.............t...........p......p.......s............s..........l.....h............l....P.t...p......A..l.....h.....t....p..s...................................................................................................................................................................s.t...t...h.....V...h...l.......h....p....ps..................ph....p.h......p.............V.p...................l..u..t............ss.t.....s...l........................hpG..Lp.G-pll..................................................................................................................................................................................	0	1643	3132	4033
+12536	PF12701	LSM14		Scd6-like Sm domain	Anantharman V	pcc	Anantharaman V	Domain	The Scd6-like Sm domain is found in Scd6p from S. cerevisiae, Rap55 from the newt Pleurodeles walt, and its orthologs from fungi,  animals, plants and apicomplexans [1]. The domain is also found in  Dcp3p and the human EDC3/FLJ21128 protein where it is fused to the  the Rossmanoid YjeF-N domain [1,2]. In addition both EDC3 and Scd6p are found fused to the FDF domain [1,2].	25.80	25.80	25.80	26.80	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.07	0.72	-4.18	156	564	2012-10-01 22:42:21	2009-12-15 16:50:39	2	12	284	5	358	507	3	94.00	40	21.39	CHANGED	..ssssaIGSpISLISKu-.IRYcGh.LasIss...ppST.......luLps.....................V+SaGTEsRtps.......lsspsplY-aIlFRGSDIKDLpVt-ssp........shssDPAIlpsph	..................hssalGSpISLIScsp.IR...........Yp.GhLhsIss...cpuT.......luLpp.............................................................VRSFG.TEsR.sst..........lsPpcpla-.YIlFR..GSDIKDLpVt-sst...........shspDPAIlt...h............................................	0	104	170	266
+12537	PF12702	Lipocalin_3	DUF3803;	Lipocalin-like	Coggill P	pcc	JCSG_target_392987_3hty Pfam-B_17140 (release 24.0)	Domain	This is a family of proteins of 115 residues on average.  The family has two highly conserved tryptophan residues. The fold is very similar to the lipocalin-like fold from several comparable structures.	20.20	19.40	20.20	19.40	20.10	19.10	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.13	0.72	-3.96	17	79	2012-10-03 08:47:39	2009-12-15 17:12:47	2	3	61	16	8	74	2	90.60	30	55.05	CHANGED	sptsllGsWlpPlss.s.sthQGhpLctsGpAoSINMsTLhYcp....................Wc..ppGspLlLoGpShGNst..s..hp-ThpIcpLTscoLlL......cptshplpYs	.....................pllGsWspPhshps.sthpGhplcpsGsAS.SI.NMsoLpYcp.........................Wc..hpGs..pL.lLpGpShGstt..s..hssohpIcplopcoLhL......pstt........................	1	6	7	8
+12538	PF12703	plasmid_Toxin		Toxin of toxin-antitoxin type 1 system	Gardner P, Coggill P	pcc	Gardner P [1])	Family	This family is the toxin of a type 1 toxin-antitoxin system which is found in a relatively widespread range of bacterial species. The species distribution suggests frequent horizontal gene transfer.  In a type 1 system, as characterised for the plasmid-encoded E coli hok/sok system, the toxin-encoding stable mRNA encodes a protein which rapidly leads to cell death unless the translation is suppressed by a short-lived small RNA. The plasmid-encoded module prevents the growth of plasmid-free offspring, thus ensuring the persistence of the plasmid in the population. Plasmid-free cells arising after cell-division will be killed because the stable mRNA toxin is present while the comparably unstable anti-toxin is rapidly degraded. Where the system is transcribed chromosomally, the mechanism is poorly understood [1].	19.40	19.00	19.40	19.00	18.80	17.60	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.39	0.72	-4.16	6	28	2009-12-16 11:43:50	2009-12-16 11:43:50	2	1	28	0	8	18	0	70.20	59	92.47	CHANGED	Mss.p.hpstpslHpsAh.LuuLcalDQcsARpLu.hAEAVANhFMVVFYQAETGRATptDFpEAMsAlRQuhp	.......................MsTtHsIE..spQAlHQAAhpLAALEaIDQcsARplhPlAEAVANhFhllYYQAETGRAT.pDFpEAhsslRQsh.p..	1	3	4	7
+12539	PF12704	MacB_PCD		MacB-like periplasmic core domain	Bateman A	agb	Jackhmmer:3ftj	Family	This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein [1]. Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.22	0.70	-11.73	0.70	-4.77	1392	21380	2009-12-16 11:56:13	2009-12-16 11:56:13	2	26	4469	3	5700	17502	5573	229.30	13	48.61	CHANGED	Ah+slhpp......+hRoh...Lohl......G..lsl..G..luu..llsh.hu.ls.pu...hppp.htpp..h.....tp....hus..sh.......lh...lpssts..................................................t.tt.t..sl.s..h.ps.hpt....lp............ph.s.t.lpsl..ss....th..s....................hplph..............sspstss...............ph.G..................ss.s.s.hhph............h......s..h..pl.hpG...chhstt.-...............tpss...llu.p.sl.Acp.las.pt.t..........s.....lGcp..lpl...............................s.....s......s........................hpVl...Glh.....p.............sp....st....................t..s................ttlhlPhsshp..........................phhtt...................................tthsplhlp.........hpsss..s.hsp..................s.ppplpp....h	.....................................................................................................................................ttlh..t.p.......ph+.....s.h......l...s...h...l..........u.l..sl...u......l.sh...l.l..s..h...h.u..l.h..pu...h..p..p..t...hppp....h..........tt....hss....sh.........lh......lp.ttt.................................................................................................t.th..s.....p..p..hpp..lp..................ph.s..s..l...p......s.......s...ss....hh...s.................................s.lph..........................sspp.tsh............................................................p.hhG..........................ls..s..s..h.hph....................hs.h....pl.....hp..G.....c..h......h.s...t.......t...........................................pptl.................l...l..s..p......p.......l....A.............cp...hth..p.................................................lGc.p...l.pl...............................................................................s..t.....s.......................................hpl.....s......Glh....p......................st......t........................t.s......................................thlhh.s..h.sshp.........................................................phht..............................................tthsth.hlt........hp.ss...p...tt.h.......h....................................................................................................................................................	0	2422	4192	5077
+12540	PF12705	PDDEXK_1		PD-(D/E)XK nuclease superfamily	Bateman A	agb	Jackhmmer:Q18AP1_CLOD6	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.99	0.70	-5.01	258	8235	2012-10-11 20:44:46	2009-12-16 13:18:01	2	43	4486	8	1945	8551	4890	244.70	14	25.38	CHANGED	phSsSp.lcpatp.CPhpaah..ph.hh............plpttp...........th.pshs...............................hGslhHp......slcp..............hhp......................................................p............hptp.................................th...t.............................................ptt..thtpt.h..pt...................h.h..pp...htp..hht.........................................................................................tttt.......hp...hth.....Ehphp........hph.s..........................................sl...pl...pGplDRl........-tt....ssp.......................lpllDYKTupp..................sh....shp..........................................ch.....h.....h...ph..QLhhY.hhshtptt..........................s.pstsss....hhah.p.hppstht.................................................................................................................hp.ths....ppp..hpt..hp...p...pl....pphh.p.pl.t....p......httt...............................................h..t...psppsC.....p....a....CsapslCt	................................................................................................................................................................................................................................................t...............................................................................tshp....................................hGs.hhH.p..........hh...c.p..............h..t.....................................................p.......h..t..................t.h..............................................................................t.t..h..t..t.t..h..pt.......................h.....h....pp..........ht.p..hh..t....................................................................................................................................................................t.t...........hp......h..th........E.ht.ht.......htht.......................................................sh..hl.....pG...h..l...Dtl...............................pt.....ssp.............................................hhllD..YK..osph...................st...s.t...................................................ph.....t.......h.....ph.Qhth.Y..t....hslpphh.................................shp.h.t....s..t.....hh.a.h.h...h.t..t..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	700	1353	1685
+12541	PF12706	Lactamase_B_2		Beta-lactamase superfamily domain	Bateman A	agb	Jackhmmer:Q189N7_CLOD6	Domain	This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.84	0.71	-4.76	268	12584	2012-10-02 15:46:01	2009-12-16 14:03:32	2	97	4382	48	3955	21211	7413	209.10	16	60.92	CHANGED	pt..lLhDss.s........................................tht.thhtt.t....h........tlctl.......lloH.........sHhDHh....hsh..hhpshhth.t..........................hlhss..................sstptlp.................................................................thsh..................p..........ht.hsht.........................................................................lps....h.sspHtsst.h...............................................ahlp........................................stplhau.uDssh........................................h........tth....................................pp...............hDlhlhssshh......................t....hHhsh........ppulphhp.phssc...p....hlhhHh	..............................................................................................................................................................................................................................................................................h..hLhDss..s..........................................................................h......................plc.t.l..........hl.oH.........hHh..DHh..........hs.h........h..h..t..hh..thhsp.................................h.laus........................................ts.s..t...p.h..lp.............................................................................................................................................t.th....................................................h....h...h..p......t.p.........................hh.p.h...t..s.hp................................................................................................lps..........h....ss..p....H.s.s...s.s..hs.....................................................................................ahlc....................................................................s.sstp..l..h.as..GDoth.........tp............................................................h....pth..............ps..................sDl.hl...h....-s.s..hh.....t......................................htH.hss.........................pp.s...h..p.h...t...p...p....h...t.sp.......p.......llhhHh.......................................................................................................................................................................................................................................................................................................................	0	1384	2524	3317
+12542	PF12707	DUF3804		Protein of unknown function (DUF3804)	Coggill P	pcc	jcsg_3hzp	Family	This family is approximately 130 residues.  Dali search indicates this protein carries a NTF2-fold with a hydrophobic cavity as a structural homologue to 1JB2, 2R4I, 3FSD and 2UX0.  In this hydrophobic cavity, Arg 118 provides the H-bonding force to hold a PEG molecule from crystallisation. The interface interaction suggests that the biomolecule of Swiss:Q46KI2 is a dimer. Two members of the family are annotated as putative EF-Tu domain 2 but there is no match to this family so this is likely to be a false assignment. There are two highly conserved tryptophan residues towards the C-terminal end of the family.	22.50	22.50	23.00	44.60	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.65	0.71	-4.56	5	18	2012-10-03 02:27:24	2009-12-16 16:10:09	2	1	11	1	8	19	129	107.30	53	96.55	CHANGED	SDocpIEuLIpGFAsscc.uSFLlsNsTsDFLAIRPSGNPIoAKGLsGMasSuDLVlEsSELlKIHRLEhhuushuaAlFTLsEpFSYKGspNcDLSTYTsIFKKlDGsWKISWMQRSoGTTDLSTWN	........tl.shlpthss.p..toFhhsNsTsDFLhIRPSGNPIsAcGhttMh.osDlV.EtuElsKIH+hEh.ss.shuhshFTLtppFoYKGs.NcDLsohT.IFKKlcssWKlsWMQRSoGsoDhShWs...	0	1	7	8
+12543	PF12708	Pectate_lyase_3		Pectate lyase superfamily protein	Bateman A	agb	Jackhmmer:Q184L0_CLOD6	Family	This family of proteins possesses a beta helical structure like Pectate lyase.  This family is most closely related to glycosyl hydrolase family 28.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.85	0.70	-4.23	90	2481	2012-10-02 14:50:22	2009-12-16 16:15:15	2	119	1227	26	988	3936	234	234.90	16	41.55	CHANGED	aRN.V+D........aGAcGD..Gso....DDTsAIppAIt............ts..ssusosssAlVYFPsGTYlloss.....................Ih.hhhT.........pllG..sstshssl+...usssas...Ghsllsu.s.hht.........................pssFh.ht.....l+N..hhlDhsshsh.st..............sulcWts.........uQuoolpNl..........hhp........hsss....ssspp.Glah-s.....................uu........sshh.sclhhsGGshG...........h..hhus...........Q................QaohcNhp..........hss.spsuIthhhshs..hshps...hslsssts.....................G..ls	..............................................hs.l.p.-.........a.GAt.GD..........Ghs..........DD.T......t...A.lppAl...............................t.s.ss..ss.ss.h...V..a.h...P...s......G..s....Y.....h...lsps......................................................................................lh.l....h..s....s.s.....................................................p.l.....h.G.......s....s...h..........s..................s...h...l...t.......................s..s...s..t...h.t........................t....h..t....h.h.t.s...p....t...............................................................................................................................................................................................................lps.........hhh....s..h.s..sh...............................................................s.hpht.......................................................................sps....s.t..l.ts...l..........h....................................h.......................................s..............t...........................s...h.hpt.........................................................................................h........s....................s.....................................................................p...........................................................h..htp.........................h...................s..........................................................thh.................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	293	584	826
+12544	PF12709	Kinetocho_Slk19		Central kinetochore-associated	Coggill P	pcc	manual	Family	This is a family of proteins integrally involved in the central kinetochore. Slk19 is a yeast member and it may play an important role in the timing of nuclear migration. It may also participate, directly or indirectly, in the maintenance of centromeric tensile strength during mitotic stagnation, for instance during activation of checkpoint controls, when cells need to preserve nuclear integrity until cell cycle progression can be resumed [1].	23.00	23.00	23.80	23.80	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.16	0.72	-3.91	14	100	2009-12-17 14:51:34	2009-12-17 14:51:34	2	2	99	0	76	98	0	82.20	38	10.97	CHANGED	shpcphpppcp-sscplphlA-DLYsQYSSKHEpKVphLKKuYEs+apc+lcclphcspslpcEl-pLcspLp.ERcEKppLlplL-	............tt....phppss+EVpcAVE+VARELHsLYKuKHEoK..VsAL...KKSYEsR...WEK+l+-lcpclcshpcEsEcL+pph...............t................	0	11	35	63
+12545	PF12710	HAD		haloacid dehalogenase-like hydrolase	Bateman A	agb	Jackhmmer:Q18AI1_CLOD6	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.83	0.71	-4.14	272	9618	2012-10-03 04:19:28	2009-12-17 17:10:43	2	102	3541	13	3687	38047	3600	244.60	16	47.47	CHANGED	shFDhDuTL.........hsss..h.............................hhhhhtth..........................hhh............................................................................................................................................hsth...........thhch..hh..............................tthtshttp...hhp..tht........................................................................pshh.................phl...t...............ppt....Gtp..lhllous.........p.....hhcsh............ht....thshst..llusph.....................................................................................h.....ttth...ssp.htt..........tKhp.....tlpph..................................................hhhGD..uh.s..Dlshlp	..................................................................................................................................................................................................................................................................................................................................................................................................................................................hhhDhDuTL..........................hppc.......h..................................h...hsth.h..h..................................h.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.h..pt...............sht.p.....ht....................................................tt.h..t...s.h....t..t.t.......hhp......tht................................................................................................................................................................hhtshh...............................chl...........pp..................lp..pt........Ghc.........lhll....oGu.................hp........hspsl.......................................sp..............phs.l..s...t...............h.h..us.ph.......t..........................................................................................................................................................................................................................................................................................................................................h.h.t.sch......ssp.....................t.Ksp...........hlpch............................................................th.thttshuhG.D..us.N..Dlshl......................................................................................................................................................................................................	0	1113	2065	2970
+12546	PF12711	Kinesin-relat_1		Kinesin motor	Coggill P	pcc	manual	Domain	This family is closely related to Kinesin-related, Pfam:PF06548.	26.90	26.90	30.40	30.40	26.80	25.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.79	0.72	-3.58	20	117	2012-10-05 12:31:09	2009-12-18 13:10:42	2	3	54	0	61	122	0	86.50	42	5.74	CHANGED	RE-KIpRLEsLhsGsLss-salh-Es..psLpcEIclL+ppl-+sPEloRaAlENhRLpEpl+phppFh.-pGEREhllpElspL+spL	.......REDcItRLE+Ltcpuhsu.hsppp-p...ppL+-EIphLR-QlE+pP+ls+YAhENppLREEs+RL+thpsVcpspEh.spplupLEctF.....................	0	11	24	38
+12547	PF12712	DUF3805		Domain of unknown function (DUF3805)	Coggill P	pcc	JCSG_target_3hlz	Domain	This family represent the N-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1tui, also of unknown function. The domain carries four conserved tryptophan residues.	21.80	21.80	21.80	21.90	21.30	16.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.89	0.71	-4.43	6	50	2009-12-18 14:33:49	2009-12-18 13:56:41	2	2	50	2	7	40	1	153.60	68	57.55	CHANGED	M...KKaISPGuWFShpYPuDWsEFEDuEsSFLFYNP-+WTGNFRISAYK.....ssussYGp-slcpEL+ENsSApLVKVGcW-CAYSpEhFQEEGsaYTSHlWVTGt-sluhECSFTVPKGEsl+tAEcIIASLclRK-GsKYPtEIIPlRl.EIhpIN	...hQG.KKFISPGuWFSMpYPuDWsEFE.DGEGSFLFYNP-p.WTGNFRISAaK......GsAsYGK-sl+QELKENsSAoLVKVGph-CAYSKEMFpEEGsYYTSHLWlTGh--lAFECSFTVsKGssVcEAE-lIAoLElRKEGpKYPAElIPlRLSEIYpIN....................................................................	0	1	5	7
+12548	PF12713	DUF3806		Domain of unknown function (DUF3806)	Coggill P	pcc	JCSG_target_3hlz	Domain	This family represent the C-terminal domain of the structure. In two related Bacteroides species the gene lies immediately upstream from a putative ATP binding component of an ATP transporter and a putative histidinol phosphatase. The structure of this domain is strikingly similar to the N-terminal structure of 1ma7 whose C-terminal domain is a phage integrase, Pfam:PF00589.	20.70	20.70	21.40	20.80	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.62	0.72	-4.52	25	109	2009-12-18 14:36:53	2009-12-18 14:36:53	2	2	100	2	30	98	23	85.00	28	39.15	CHANGED	pDlsslQpllDpuhlssccpp......s.hpuhGlslGslLssEh.tGh-WhsltDstscs.uLphtsoc.thlh..Phshlhc+hcsGptsslschY	.........................DlpplQpll-puthssccpc......t.htuhGlslGslLssEh..Gh-WhslhDsttcs.sLpht..ssp.hhl...Phpllhp+lcsGp.sslhp.a.............	0	10	26	30
+12549	PF12714	TILa		TILa domain	Bashton M, Bateman A	pcc	Pfam-B_897 (release 5.2)	Domain	This cysteine rich domain occurs along side the TIL Pfam:PF01826 domain and is likely to be a distantly related relative.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.61	0.72	-4.21	42	957	2012-10-01 23:42:56	2009-12-18 15:44:45	2	141	60	0	540	797	0	55.90	33	10.67	CHANGED	GCpDspGshhPsGcoWhoss.CoppCsC.ssGtIpCpsapCsssohCp.p..sGspsCt	.............GCh.hpG.p.Y.a.s..G.c.p.ah...s.ss..CsppCpC.t.s.s.u.tl....pCps..t.p.Csssp.h.Cplp..sGhhsCh..............	0	58	113	320
+12550	PF12715	Abhydrolase_7		Abhydrolase family	Coggill P	pcc	jcsg_3g8y	Family	This is a family of probable bacterial abhydrolases.	20.70	20.70	20.70	20.70	20.60	20.20	hmmbuild  -o /dev/null HMM SEED	390	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.29	0.70	-5.54	4	102	2012-10-03 11:45:05	2009-12-22 11:09:37	2	2	85	7	21	133	18	320.60	36	84.06	CHANGED	ppapPp-Hsll+SsRsDGRaLSSYGlVHsMLcchcPphAFpsDMSs+EFspWQctVR+AMpEIMKFPp.pcp.PuPVClKT.pREGYRLEKWEaYPhPcsVSTFLVLlPDsl..ppPVPulLCIPGSGtoKEGLAGEPGlssKLs-.cYpsP.KloMAhNhVKpGYlAVAVDNsAAGEAuDLE+YstGpNYDYDllSRFLLEhGWSaLGYsSYLDMQVLsWMKopsaIRKDRIVlSGFSLGTEPMMVLGsLDssIYAFVYNDFLCQTQERAhVMThPDKpGpRsFPNSIRHLIPsFW+pFNFPDIVAuLAPRPlIhTEGGLDRDFpLlppAYthuGtP-NschaHYPKFADPspRKcl-pLPEGLDRcpYFchVNVDsPsHYFKsELVIPWL+Kl	..................................................................................................................hhtsh...........................................................ppatpWRpp...s.Rchlp.p.hh........h.hP..s.ssh....s.....a...ssch........l..c.pp...c.Rs....u.Y.hsE.Klth.slo..sc..SR..VsuhLLsPcth..........cGPaP..A..llhL..H..G.p....s..h....s....K....EK....hl............t.....h.G.s....s..sc...lss.......sh.sct.........tph..........hG..........c.p.........LA.....K+G....YVVlulD....u.luWG-.....R.....G....s...h.....p.....h.....pp..t................p..sLAsshh.....p.....LG.pShuGhh....uY-....D.M.R.slDFhsoLPpVD+cRIGlhGFSMG.uaR.uW.LAALsDpl.tAss....hhuahsph.....thhhhsssps....htu.tsuhhhLhPGlhp.phDaPDlASlAAPRPhLhh....N......G.........u.....cD.........+.........L.....F..........h..V....c..pAYt.......................................................................shthhhttt...............................................................................	0	4	14	17
+12551	PF12716	Apq12		Nuclear pore assembly and biogenesis	Wood V, Coggill P	pcc	Wood V	Family	This is a family of conserved fungal proteins involved in nuclear pore assembly [1]. Apq12 is an integral membrane protein of the nuclear envelope (NE) and endoplasmic reticulum. Its absence leads to a partial block in mRNA export and cold-sensitive defects in the growth and localisation of a subset of nucleoporins, particularly those asymmetrically localised to the cytoplasmic fibrils [2]. The defects in nuclear pore assembly appear to be due to defects in regulating membrane fluidity [3].	25.00	25.00	26.60	25.90	22.80	21.80	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.53	0.72	-4.27	34	86	2009-12-22 13:18:28	2009-12-22 11:51:49	2	1	85	0	63	74	0	52.00	27	30.96	CHANGED	hPslssllhlllllalsh+llchhhRhhhhhlhhll+lsaassllshuhhlYhp	....Pclssllhlllhlalsh+lLshhhRhhhhalhhll+lhaassllssshhlYhR...	0	11	31	52
+12552	PF12717	Cnd1		non-SMC mitotic condensation complex subunit 1	Coggill P	pcc	Pfam-B_410 (release 24.0)	Family	The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.06	0.71	-4.43	77	571	2012-10-11 20:01:02	2009-12-23 16:26:08	2	33	298	0	412	1562	22	172.30	27	14.18	CHANGED	sshlRsNhllsluDLshRassll-.a....sstlh......ppLp.....Dp..s.......................shVR+sslhsLo+Llhp-hlKh+Gpl.hchhhsL...tDssppIpshAchhhp-ltp+....s.shl....hNhhs-hls....tLsp..ttt............................hsppphpplhpallshlst..........-+ppcsls-Klst+httsp...............................................stp.hpclhhhLshhp	.................................................................................hlRsNhlluluDlslpa..s.sll....-.h.....sstlh......tpLp...........Dp..s..................................................................V..R+...s...slhsl.......op....L.....I...h....p....s..h.....l..K....l.K....G...p.l........s.c.hs.t.s..............L......Ds..spc...I.sshAc..hhFscLs..pK........sssl...........................aNt...h.s-.hls....pLss..................................................................................................................................thpccphppIhcaL..l..p.h..lp..............................-.c.pt.pl.s..pKlstch.ts..........................................................stp.hpDhhhhLs.h.....................................................................................................................................................................	0	152	231	339
+12553	PF12718	Tropomyosin_1		Tropomyosin like	Coggill P	pcc	manual	Family	This family is a set of eukaryotic tropomyosins. Within the yeast Tmp1 and Tmp2, biochemical and sequence analyses indicate that Tpm2p spans four actin monomers along a filament, whereas Tpmlp spans five.  Despite its shorter length, Tpm2p can compete with Tpm1p for binding to F-actin. Over-expression of Tpm2p in vivo alters the axial budding of haploids to a bipolar pattern, and this can be partially suppressed by co-over-expression of Tpm1p. This suggests distinct functions for the two tropomyosins, and indicates that the ratio between them is important for correct morphogenesis [1]. The family also contains higher eukaryote Tmp3 members.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.97	0.71	-4.34	41	292	2012-10-03 05:16:33	2009-12-23 16:36:48	2	14	225	0	176	1155	1	117.90	33	58.23	CHANGED	KhpsLKlEs-sAt-+sEphcpchKphEpcshcpEpElpSLp+KsptLEs-l-clEppLp-s+sth--uppttopsE....uLsR+lQLLEEELEcu-cpL...+ETsEKLccs-hpA-chERphpsLEpcppp.EcKhE-hpcphccu+t	...................................KhptL+l-t-su.p+.s-phctchKphEpc.sh.........p....p...Ep..ElpuLp+K...phlEsEl-...Kl.c.p....pLp-scpthc.p....s...pp..t..t.sps-...........shp.++.p.lE....pph-psc....tpl.......pps.p.clppsphtutp.t..Rt..h..hp...p.....t...-t+..t.......t........................................................................	0	56	93	142
+12554	PF12719	Cnd3		Nuclear condensing complex subunits, C-term domain	Wood V, Coggill P	pcc	Pfam-B_484 (release 24.0)	Family	The Cnd1-3 proteins are the three non-SMC (structural maintenance of chromosomes) proteins that go to make up the mitotic condensation complex along with the two SMC protein families, XCAP-C and XCAP-E, (or in the case of fission yeast, Cut3 and Cut14). The five-member complex seems to be conserved from yeasts to vertebrates. This domain is the C-terminal, cysteine-rich domain of Cnd3. The complex shuttles between the nucleus, during mitosis, and the cytoplasm during the rest of the cycle. Thus this family is made up of the C-termini of XCAP-Gs, Ycg1 and Ycs5 members.	25.80	25.80	25.80	26.60	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.86	0.70	-5.43	57	330	2012-10-11 20:01:02	2009-12-23 16:51:05	2	9	263	0	236	335	0	307.10	23	30.42	CHANGED	h+CLtlspthLpplp.tslppshpl...sllssLlh...Pulpsp-s.slRchulcCLGLhsLLsc..........plAp-sh.lhhpth.pp.........s.ssplphhAlpslhDllhhaGhphhsspsp........................................stshslhclhh+hLcss......psc......lpshusEGLsKLhLsshlss........................................................spllpsLlltYFsPpopssp.................tLpQsLuhFhPlYsaSphpp..Q..pphtpshhsslhplhph.tch.........ssts.lp...........ssplhphllchTDscphsshsptt...................ttssH.tlu....hplLptl.......t..pscc...p+hlhphLs+Lhls..ps.s...ppphpth	...............................................................+CLhlstthLpphp...ts.hp.shsh........sllpsLllPulpstcs.slRphulhCLGlssLlsc......................phApcp.hsl.hhp..hh..pp.........s..ptslph.sA.....Lpsl..hDllh.ha...G.....hp.hhssptt..........................................................................................................s.ttsllcl.hhch...Lcsp..........ssc....................lpshuscGluKLhLsshlss........................................................sclLp.pL.llh.aFsP..to...pp.s...........................p.L+QsLu.hFhPsas...........h..u.....ph......pp.Q.........pthp..cshlss.lps.lhss.ts....................ss.s.ls...........hsplsphllchTcspths..s.sptt.................................................t.ssH.slu....hclhppl............ht...spt..tt+hhhphLspL.ls...t........th......................................................................................................................................	0	86	133	200
+12555	PF12720	DUF3807		Protein of unknown function (DUF3807)	Wood V, Coggill P	pcc	Pfam-B_6113	Family	This is a family of conserved fungal proteins of unknown function.	25.00	25.00	30.50	59.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.88	0.71	-11.46	0.71	-4.10	19	65	2010-01-04 17:41:02	2010-01-04 17:41:02	2	2	65	0	54	64	0	172.50	31	78.96	CHANGED	DLpuFpAcHFssps.................sssshst................tppshsE-h............DDsLGYYPDGsKRTLTDEQIpIFRHSEIcuLhRc+chpc.-p....t.............hp.ttchps..t..s..tp.tt......................ttpppssptpc+ptpstpcpsspps...........h.ss.ttstssLcYs-csstttpt.......psssshuRRllS..........Y-D	...................................DL.sFaspHFsspsh.................................ptp.ttt................tpsshpE-.t...........DDuLGYYPDGVKRTLTDEQIpIFRHSEIc..uLhRp+chpcppp................................tpstspssspt.pts..stssptpttps............................sppppstppppKp.ppshpcppspts.........tpphsssptuh...ssL.-hsppt...............sp..tR+hls................................................................................................................................	0	8	23	41
+12556	PF12721	RHIM		RIP homotypic interaction motif	Coggill P	pcc	Masci AM	Family	RIP proteins are receptor-interacting serine/threonine-protein kinases or cell death proteins [1]. This interacting domain is involved in virus recognition. The RHIM domain is necessary for the recruitment of RIP and RIP3 by the IFN-inducible protein DNA-dependent activator of IRFs (DAI), also known as DLM-1 or Z-DNA binding protein (ZBP1). Both the RIP kinases contribute to DAI-induced NF-kappaB activation. RIP3 undergoes auto phosphorylation on binding to DAI [2].	17.20	5.30	17.20	5.30	17.10	5.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.52	0.72	-3.55	28	243	2010-01-08 12:49:32	2010-01-08 12:49:32	2	18	70	0	89	231	2	48.60	23	10.48	CHANGED	PsPpsss.sssssspss....................ssssshslsIp.sssulQIGspNhMslp	.........................................................................................................s...................................tss...ltIp..su.pslQIGssNhMph.......	2	23	32	39
+12557	PF12722	Hid1		High-temperature-induced dauer-formation protein	KOGs, Finn RD, Coggill PC	pcc	KOGs (KOG2226)	Family	Hid1 (high-temperature-induced dauer-formation protein 1) represents proteins of approximately 800 residues long and is conserved from fungi to humans. It contains up to seven potential transmembrane domains separated by regions of low complexity. Functionally it might be involved in vesicle secretion or be an inter-cellular signalling protein or be a novel insulin receptor [1].	20.50	20.00	20.70	20.00	20.20	19.90	hmmbuild  -o /dev/null HMM SEED	895	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.58	0.70	-13.63	0.70	-6.87	28	348	2012-10-01 19:21:38	2010-01-08 16:35:52	2	7	227	0	260	575	7	599.10	26	91.93	CHANGED	MGso-SKLs..F+pulhcLspp.............................................pth..ss...............--s...aWppFW....chspospDlFs.Lloss-IRplRDps.sNltoLlhtlsp+lhhhspp.ssh..............shs.pp..plLNClRlLTRlLPalaE....tppWcs..taFWusp.c.hh..t...............................tt.psspPLAtpLlcuLlDLLFhssFTlssst..........pshspspa.IWEuGVGsssshsp.......stch-uNRsElL+LLLTlhScshYhsss.......sspss+alsahsosss+p.lLsLhsSLLNsss+Yssss....hslPY.splhapDs+p..............................hLVphsL................QlLllhlsashssssph...................................................shscNhahpYLu+lHRcpDhpFllcGhs+lLppPlp...........................................................................................pohlPsss+.lpa..t.EhLhLhWchhphNK+Fhpalh-opcshDlllhhlYalhpa+sssu+hG....................................ll+hssalLLhLSu..-+sFsh+LNcsass........ppLP.........h+lsshsG.....TauDalIl.hppll.............sosptp.p.lhssLlpllhNlsPY.......................................hpsLShsuuspllpLlsshSoPtFLhu................................sssNacLLthLL-shNshlpapFcs................NtpLlYullRp+clacpLtshsh-.upp.hptpsp.............p.............................................t...tshtsspppsstps.ptss..pssps.t.sphs.p.ssshshssspsptsp..cspss.ssss....................t.s.t.pt.p.tsttp.sthp.thspppsspp.p.sssh..psptpatsossWhcSWtscL..sLpoIhpll....pslhspl.phshppuhss-u.hl.....chhpcsplpulls.......sPpPlpl+paphsshohtWacolhWGhIaspph..............................................................................................................t............................................................................................ssslWssTclKLFcl	.................................................................................................................................................................h..tL.t............................................................................................................................s........................sp.........hatthh.....t...p.p-lht.hhs.tpl+.ht.............ptt...NhtsLhhhhs.plh.hh..pp........................................p....p.....hlNs.Rl..Ls+llPhhh.....E..........thpt..................hhWt..........................................................................................................................t..sLuppLl.slhcLLFh.sF.....Tl.......................................................t.tp....h.lWpsG..luhsts................s..ht.sR...hElL+LLlshh.upshY.s.t................................s.hl.hhss.............sp......hhshhsSllNssh....ths.ss...................tls..a..s.hh.h..t..s.pp..............................................................hl..sh................phL.......h.hl.a...........................................................................tNhhh.a.hsp.lp+.t...Dhp.....hl.....hpuh..plht.sh...............................................................................................thhst......p...h...h.phhh.hhaphhphNppFh.hh.hp...t.s.c....hll...hl..h..hh...ctp..t.p.s.....................................................................lhphs.all.hLSs....c.th...h.p....L.p..hp..........plP.....hc..ls..h..s.......................oat.Dhhl.h.hhp.ll.........................hss......t...............l..h..shhhthl...N..l.sh.............................................hptlu..ss..plhpLhtthSs..a..Lhs......................................................................................s..ph.....hl..l..Lc.hsshlth..phpt....................s..Llasll..+ppphhp..tlts..h..p.st.........t..................................................................................................................................................................................................t............t.................t..t............................................................................................................t..............................t.........................................t.........th..s..a.............h.sW..ph..sLphlh.pll.....p.l...l.....t.....t.t....t.............t................h..h.........................sh..t...hp...............s..h.hhWh.thhWu.la.tt...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	101	146	222
+12558	PF12723	DUF3809		Protein of unknown function (DUF3809)	Bateman A	agb	Jackhmmer:NP_295729.1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in Deinococci bacteria. Proteins in this family are typically between 117 and 157 amino acids in length.	25.00	25.00	42.00	73.70	23.40	17.00	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.94	0.71	-4.28	6	19	2010-01-08 17:04:36	2010-01-08 17:04:36	2	1	19	2	13	19	1	127.90	38	90.81	CHANGED	oFsLphPus.ApuLs....Pthshuth..h+sLpt-uEtlcGELVspsPlLGElDLPFpSRLphpspGt....pLhPhsLsGE.s..WlEVuGpupssEsG.lsaphphRsHLsLPpuEsWGGtAFc+MlcAAhuRTLERVhppL	........................................shs.h...h-Lch....-upplcGpLhtpsPlLGElcLPFtSRL....-Gt....pLpPlPL...ss..hlEVpGpucss....u.....tu....lththclcl+LpLPpGcsWGtRAFt+hlcAhFtRsLERsLst....	0	3	8	13
+12559	PF12724	Flavodoxin_5		Flavodoxin domain	Bateman A	agb	Jackhmmer:Q186N5_CLOD6	Domain	This is a family of flavodoxins.  Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.72	0.71	-4.19	70	1747	2012-10-03 05:08:30	2010-01-11 11:17:35	2	13	1363	0	401	2543	510	137.00	25	68.21	CHANGED	LIlYuSpcGpT+cIup...hlu...pplptt....sphsslps..h...t.th..slspaDp..VllGAul+hG+apstlhpFlppa...tstLsst.suhFsVsLs........uccspc.........h...hc.+h......l.p..sh..a..p.....PphhtlFu..GuL.pYs+Ysah-+hhlphI.hph...stup...s-ss	.............................................lIlYu..o.p..p..G.pT+clAp...hl...A....p...pLpp.................sths.....clps.......s..............................p.......p....................s......h.p..sY.......Dp.....lllG.u.u.l.h.h..G...+.h..p...s..t..h..p.c.Fl.c.+.p.....t.s.p.L..s..s.....h...s.u..h..as.l..shs............upc.s.pc..............................h...hp.ch......l.p...p.....h.....p...........st..hthhs..Gtl...h..phthhc+hhhphh.ht...tt.....t................................................................................................	0	140	253	344
+12560	PF12725	DUF3810		Protein of unknown function (DUF3810)	Bateman A	agb	Jackhmmer:Q185R6_CLOD6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 333 and 377 amino acids in length. There is a conserved HEXXH sequence motif that is characteristic of metallopeptidases. This family may therefore belong to an as yet uncharacterised family of peptidase enzymes.	26.10	26.10	26.30	61.80	25.40	26.00	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.94	0.70	-5.53	60	206	2012-10-03 04:41:15	2010-01-11 13:16:19	2	1	203	0	62	211	151	314.90	30	87.94	CHANGED	hYSpslYPhluthlphlhuhhPFSlGD..lhhhl..hllhllhhlhhthhphhpphtph...............h.hphhthls....llYhhFhlhWGlNYaRhshtpph..........slphtp.Yos-cLhphsptllppsNphptplsp..........spshhhths..s...pclhcpsh.puYpplsppashhp..hp.hspsKsslhShhlShhGlsGhhsPFTsEAplNsplsshphPhThsHElAH.lGaupEsEANFIuYLsshpsss.ha+YSGahhuLhYslspltc.hs.ctapclh.pplssslhc.shppsppaWppa.cs.sl......spltphha-tYLKuNsQpsGhcSYuchVsLLlu	.............hYupslYPhluthlshhsuhhP.FSlG-.lhhhl....hllhll.hah.hht.hh.phhpphpph......................lhphhthls....hlYhhF.....hlhWGlNYhRhshhpph..............................pl.phtt......ao......s-cltphspphlpphNphtsplsp............ssp..h..............ppltpcsh.puYpplsppashhp...sp..hspsKsh.lhS.lhShhGlsGhhsPFTsEuslNspl.shphPhThsHElAH.hGaupEsEANFluYlsCppusshth+YSGYhhsLtYslssltc.hst-tapclh.pplpst........lhc..shp.ppptaWppaps..hl.........spl.tshhactYLKuNp.psGhcoYuchVsLLls...........................................................	0	31	54	59
+12561	PF12726	SEN1_N		SEN1 N terminal	Mistry J, Wood V	jm14	Pfam-B_2547 (release 24.0)	Domain	This domain is found at the N terminal of the helicase SEN1. SEN1 is a Pol II termination factor for noncoding RNA genes [2]. The N terminal of SEN1, unlike the C terminal, is not required for growth [1].	20.60	20.60	21.70	21.70	19.40	18.90	hmmbuild  -o /dev/null HMM SEED	727	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.10	0.70	-13.27	0.70	-6.48	34	152	2010-01-11 14:18:12	2010-01-11 14:18:12	2	9	140	0	119	164	0	637.60	21	33.42	CHANGED	Wlpp+hsppLpsCspClpsatpuKsphhpphh..cphstpp.lppFhphlspW-hpplhtsLcphppphpss..s..p.s........h.hulaEsLsssshL+sssthcth...FsthFchl.sppphh...h.........pphl.PGhhhhLF-s.ss..ppppWApphhpphtpp...hsppphs.slhptlshtlhpl...........s..ts.hs.shhtp.......FWpshthll..phlsp-hlppthps............htlps.lh+lhhsHLtss....stsLthlLcsLphlLc+hsssF.Ws.thpsho.p.........sll-plFssstFsphLhcsppss.hpppt................hpshh...uWhhsFhpSLsssp.p.................psscpls.hLlpphpp.pp.sp.......t+tsshtsuhshLlpslhs....hpcpcps.......shpsslhsls-shshlssth........shh.sssth..h.tpstslsphshpllppslsh.DhhtLppppttLhps........sth.sss....phhs.......lWpplhpthh.psshs...LuptlLtuht..........slsul.hh........spp..............phsstpppaNphhpphtphhspll............p+lu-h....sPspLpplhs.cp..ssspulhSsl.hSss.plhpAAhsllppsh.s.ssuRhEulpclLppphssslpulshslpplpphcs....apssP+.hl+shhDllssLsDs.sGlL.....pspphht....pssttplt....paWchtWphLshIFppThtWusp..actp.hh-FsRDTL-huchLh-paplhsssls.t.sss...........pssps.............lhpsshpshpshlhWLRLsDc.LLsssVpL	.......................................................................hhp+hpt.LppCs.Cltpaapu+tthhpphh...cphsppp.lpph.phlsph-hpRlhpsLppspthhpph.s.ptt.....................................thhhul.aEsLss.thLppsp.hpth...Fs.thFphlpsppphh..h.........................pphl..PuhhhhLF-t..st........ppppWAhp.hppht.p......hst.pp.h.......s.slhp.l..tlhth.........s...tt.hs.t...hltp............................hWpuhthll..phhsp-.lhpplps.............htlp...s..hhcl.hhsHLthp....s.sL...lL.....p...slphhLc+hsppF.Ws..shtshssp..........sll-.lhtsstapthLhp..psp...pt................................................................h.shh...uWh.sahpSLptsp..p.................psschlhh.Lhpp.hpp..t..t.......sphtChhtuhshLhpslhs....hhptpts...........phpsthhhhsph..h.thltp.h........................phh..ss.h.......t.tlst.shtlltpslth.-ht.htpph.hlhpt....................sh.............ph.t.lWptlhpth...pssht.....LupthLhuhh.............slhul.hh.spt....................tttppaNthhtphtphhspll............t+hu-h..........psppLpplhp.st..ps.tuhhuhl.hssp.phhpuAhplltth..s...tuRh-ulpthlpp.ht.sh.uhshshppl.phth.......atshs+.hl+hhhDllpsLs-s.sGhL.....pstph......ptphhtl........phWp..WphlshlappT.tWt.h..hcht.h.pFsRDshphuc.Lhsphtlhtsslt..t.t.t..................................s.tpp................lltsshtshpshhhWLRLpDp.Lhpshlt...................................................................................................	0	35	71	106
+12562	PF12727	PBP_like		PBP superfamily domain	Bateman A	agb	Jackhmmer:Q18A58_CLOD6	Family	This family belongs to the periplasmic binding domain superfamily. It is often associated with a helix-turn-helix domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.88	0.71	-5.35	186	867	2012-10-03 15:33:52	2010-01-12 08:16:29	2	14	708	0	360	5148	918	188.80	29	45.74	CHANGED	spthtpt..ss.hp..lt..hthsGShsGLtuLt.cGcsclAuhHL..h.......................cs.css..p..........aNhs.hl.......pch.h.ssh.s.hsl.....lphspRppGlhlttG...NPt......s...............................lpshpDL....sc....tslphlNRpp.GuGoRhLlDphL....pp.t....slss......................splpGYsppttoH.hsV..........................AssVssGp...ADsG.............l.G.l......pss.....At..ph.uLcFl.......Pl.sp...........EcYDLll.+phh.pc..stlptllphlp	.............................................................................................................................t............t..ht..lt..ht.....a.hGShsu.Lh.s.Lt....p....G....c....s....c.l.....A...uh.H......L...h...........................................c.s..cs..s..p.........................hN..hs..hl....................c.ch....l.sst....s..hsl........................lph.h.......p....Rp..p..G.l....h....Vt.pG....NPp...................p........................................................................Ips....h...t...D.L.............sc................ssl.+...aV..N.Rpp....G..S..G..o.R....h.Ll.D.p.h...L........pt..t........slss..................................pp.l..s.G..Y.p.....p..p...t...h........o....H..hu....V......................................................Ast.Vu.sGp.......A.D..l.G..............................................l...G....l............c.s..s.......At.......ph.....u...L...-...F..l........................P..l.tc............................................EpY...D.l.ll...+.s...t.h....p..c...h.lptllphh.t.......................................................................................................................................	0	130	258	307
+12563	PF12728	HTH_17		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q18A58_CLOD6	Domain	This domain is a DNA-binding helix-turn-helix domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.41	0.72	-3.71	461	7911	2012-10-04 14:01:12	2010-01-12 09:58:31	2	67	2491	0	2062	7447	1041	50.90	22	40.39	CHANGED	hlospEsA.chLs.l..uppo.lh.c.h...h.....c....pu..pl.sh.......t......t......hthpcp-lppalpppp	...................hospEsA.chLs..l.....SppT.lh.c.h.......h.........p.............pG.....pl.sh..............+.....hGpp....hhhpps-lppalpt..t..................................	0	792	1556	1892
+12564	PF12729	4HB_MCP_1	4HB_MCP_2;	Four helix bundle sensory module for signal transduction	Coggill P	pcc	Ulrich L	Family	This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.64	0.71	-4.93	65	4710	2012-10-02 01:04:29	2010-01-12 14:21:04	2	84	1259	0	1579	4943	147	176.50	14	30.92	CHANGED	sh..plpsKLhhh..hhlhslhhhllG..hlGhhshpphspshpshYpcpLlslphlsplcsshtphcstlhcllhs.p-psc...ppplhppl.pphppchsphhppYcpshhssc.E..+c.hhspacpphppY.pptpppllsLsppsphc.....cAhphhpspst..shhpphhpslpcLhphstphAcpttppspsph	................................................................h.pltp+Lh..hu...Fu.llhll.hl.hlu...shul..h..p...l..sp...ls..ssh...p..pl...h....p...s...p...h...s..sh....phh...s...p....lp...s...s..h....t....p....h..p...hs......h...h...p.............h....l......h....s....p.....s....s...pp..............hp...p....h.t...pp...l....pp....t.....p.....p....p....hp...p....t...h........p....p.....h......p......p.......h........h..........h.....s......s...p.....-......cp...hh.p..p..h.p...pt...h....p.p.a...h...s.....h...h....p..p.....h...h...p.....h..h.....p....p.....s.p..h...p........................p.A..h...t..h.......h.h...s...p.h.t......shh...p...t.h...t..p.tl...p.p...l.h.p.h...pt...p.stt..............................................................................................	0	404	885	1233
+12565	PF12730	ABC2_membrane_4		ABC-2 family transporter protein	Bateman A	agb	Jackhmmer:Q18D57_CLOD6	Family	This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-12.05	0.70	-5.20	293	7890	2012-10-03 10:13:34	2010-01-13 08:24:29	2	18	2165	0	1696	13517	1344	250.10	12	82.58	CHANGED	psEhhK.h...t...+...s.t..hh....hl.hhlhsll....hsh..hhh......h..hh.t...........................................................................................................................h...t....tt..h.......t....hh..........h..........h...............................................t....hhhh..........hhhs..l...hlsl.hs.uh.hh..s.tEh........psst........hp....hhhstshs+tplhhuK....hlshhl.h.hh....l.hh.ll.hhhhh.hl.h..shl.hs....h.........t.s.h.sh.s.................................hht..h.h...hhhhhh.s...l.hh.h.hh.......hhhl..h.h.....l......uh....hhc.....s....h.hhs...ls...l.sl.h....hh..h...hsh..hh........st..h.h.......................hhh.sh..s......................hthl..h.......h..th..........h.......t.s....h........h.t........s......h..s..h..........hh.s....lh.hh...hhhhllhhh	.......................................................................................................................................................................................................................................................................................................................................-hh+.h.....h...p...p.h..hh....h.h...h..h..h..h..h..h.l.........h.s.h...hhh.........h.h.h..t........................................................................................................................................................................................................................................................................................................h...........tt...h........t.....hh.............................h..........................................................................................................................hhhh...........hhhh.......l......h.hsl.....hs.....s..h.....h...h........s...pEh.............pp.ss...........hp......hhhs..t.s.h.s...+..h.ph.hhuK.......hl...s..h...hh.h..sh......l...hh....l...l....h.h....h.h.s.....h.l..h....s.h.l..h.t...h...........t..s.h.shs.......................................................................h.ht...h...h...h...h..h..h...h.h..h....h...lh..h..hh..................hhhl......hh.........l..........uh......hhc..........s.............thhs.........lh........l.sl..h...........h.h..l......hsh....hh..........sh..h.....................................................hhh..sh.t...................h.hh.....................h....t............h..................................................................................h......h.............................hh......hh..hh...hhhhh....h.....................................................................................................................	0	700	1290	1510
+12566	PF12731	Mating_N		Mating-type protein beta 1	Coggill P	pcc	Pfam-B_4610 (release 8.0)	Family	This domain is found in some fungi and is the C-terminus of a homeodomain-containing transcription factor protein involved in mating.	21.30	21.30	21.50	22.00	21.00	20.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.76	0.72	-4.11	24	64	2010-01-13 13:49:11	2010-01-13 13:49:11	2	4	19	0	5	61	0	90.90	21	18.04	CHANGED	hs.ts......DpplppsLsslcpcFhuuLcs-st.s.LssFhouaspFcshlpShpspLss-TlshlhsFussluslosshl-hpupppsht.cchss	.........hs.........t.DtpltpsLpshcps.alsuLpssst.s.lpsFhsphpp.h..psthp..u.t..p.s..pL...sspThphl.hsFushltslosshlclcsppsplp.sch..t.........	0	5	5	5
+12567	PF12732	YtxH		YtxH-like protein	Bateman A	agb	Jackhmmer:Q18C91_CLOD6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 100 and 143 amino acids in length. The N-terminal region is the most conserved. Proteins is this family are functionally uncharacterised.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.56	0.72	-3.61	235	1575	2010-01-13 15:49:26	2010-01-13 15:49:26	2	9	1168	0	352	993	72	104.10	22	81.49	CHANGED	hlhuhllGuslGussuLLhAPcsG+-sRcclpcpsp....chtcphpch.t.....................................lppphpp...........................................spcpspchhsc	........lhuhlhGussGAssuLLhA....P.cpG+-hRpclpcthc.............chpcps..pchp.pp.sppp...............................................................................................hpcphpp.........h.tt....................................hppthp.....ptttt.........................................................................................................	0	141	267	317
+12568	PF12733	Cadherin-like		Cadherin-like beta sandwich domain	Aravind L, Coggill P	pcc	Aravind L	Domain	This domain is found in several bacterial, metazoan and chlorophyte algal proteins.  A profile-profile comparison recovered the cadherin domain and a comparison of the predicted structure of this domain with the crystal structure of the cadherin showed a congruent seven stranded secondary structure. The domain is widespread in bacteria and seen in the firmicutes, actinobacteria, certain proteobacteria, bacteroides and chlamydiae with an expansion in Clostridium. In contrast, it is limited in its distribution in eukaryotes suggesting that it was derived through lateral transfer from bacteria. In prokaryotes, this domain is widely fused to other domains such as FNIII (Fibronectin Type III), TIG, SLH (S-layer homology), discoidin, cell-wall-binding repeat domain and alpha-amylase-like glycohydrolases. These associations are suggestive of a carbohydrate-binding function for this cadherin-like domain. In animal proteins it is associated with an ATP-grasp domain.	22.10	22.10	22.20	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.67	0.72	-3.70	218	661	2012-10-03 16:25:20	2010-01-25 14:57:29	2	169	264	0	277	708	92	93.00	22	12.69	CHANGED	LssLsl......................s.s......Fs..ss..sts.Ys.s..sVsp...sss.s..lslssss.p..............................lplsG...t.........................s...slsL..s............G.ss...lslpV......sup.......sG......s...........................s..pp.Ys.lsl....pRt	.....................................................................ltlp................s.s......Fs...ss....tts.Ys.s..pVst...sss.s....lslsspst....................sss...sp.l..p.l..sG..hts............................s..tslsL...s............GtNp....lslpV.........sup.............cG......s.............................s...pp.Ys.lslpR.................	0	145	224	258
+12569	PF12734	CYSTM		Cysteine-rich TM module stress tolerance	Aravind L, Coggill P	pcc	[1]	Family	The members of this family are short cysteine-rich membrane proteins that most probably dimerise together to form a transmembrane sulfhydryl-lined pore. The CYSTM module is always present at the extreme C-terminus of the protein in which it is present. Furthermore, like the yeast prototypes, the majority of the proteins also possess a proline/glutamine-rich segment upstream of the CYSTM module that is likely to form a polar, disordered head in the cytoplasm. The presence of an atypical well-conserved acidic residue at the C-terminal end of the TM helix suggests that this might interact with a positively charged moiety in the lipid head group. Consistently across the eukaryotes, the different versions of the CYSTM module appear to have roles in stress-response or stress-tolerance, and, more specifically, in resistance to deleterious substances, implying that thes might be general functions of the whole family.	21.90	21.90	22.00	22.10	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.59	0.72	-3.88	88	306	2010-02-01 16:08:54	2010-02-01 16:08:54	2	4	97	0	189	281	0	50.20	33	55.31	CHANGED	s................P.ssYsp.......................t....tppp.sss....................hhpGCLAALCCCClh-hsh	....................................P..uYsp................................ts....sppp.tsu..........................hlpGClAAL...CCCCll-tCh......	2	33	98	150
+12570	PF12735	Trs65		TRAPP trafficking subunit Trs65	Coggill P	pcc	manual	Family	This family is one of the subunits of the TRAPP Golgi trafficking complex [1]. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II. While both complexes contain the same seven subunits, Bet3p, Bet5p, Trs20p, Trs23p, Trs31p, Trs33p and Trs85p, with TRAPPC human equivalents, TRAPP II has the additional three subunits ,Trs65p, Trs120p and Trs130p [3]. While it has been implicated in cell wall biogenesis and stress response, the role of Trs65 in TRAPP II is supported by the findings that the protein co-localises with Trs130p, and deletion of TRS65 in yeast leads to a conditional lethal phenotype if either one of the other TRAPP II-specific subunits is modified [4]. Furthermore, the trs65 mutant has reduced Ypt31/32p guanine nucleotide exchange, GEF, activity [3].	29.30	29.30	29.40	30.00	28.90	28.50	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.72	0.70	-5.11	38	136	2010-02-01 16:49:17	2010-02-01 16:49:17	2	4	134	0	104	139	0	297.20	24	49.38	CHANGED	cssshhs.......hphshtphslshpsG..plp.hsp...h.....hPlphpspDslohhYKLss..................ss.st.s..................lplplphphh.......tsspspIt.hpWpTtlDFuh.h......P..spslppsspss...o.sh.......ssstssts.h........................................................sshsshtttspstst.ulphoFtGs...sVplGcsFsWpl.llNpSs.........................pshcLslhs.s..................ph...p..t..spsts.t........................spslh.pshhthhpp.st.p..........pssllsLosDl+lGPL.Psssaps-lchlsltsGhh.sL-u....l+lhDhpos-sh..-htclsplls	.............................................................................................................................................................................................................hsshhp.hph.hpph..pLthtsu..plcslsps..h....................thPlpshspDplohhY+Lss......................ss...........................s.tlpIslphp..l.l........s.ssp.splp.hpWpTplDFshsh..........................s..sp.slp.p.sppss...phsh...........sss.ssts.h.s....................................................................................................................................................................................s.ssss.t.htsss.s..hGlphoF.us....sVpsGc.FsWplhllNpSs...........................................................................ps+clslhs.s.................................ppph..tsp..ht.sps.ssst.t.tt......................hspslhs..-Nhlpthp...+psthp.............tstllsLSs.DhRlGPL.Psssats-LchlultsGhh.sl-u....l+llDlsosEth........-ltclsslls............	0	30	59	90
+12571	PF12736	CABIT		Cell-cycle sustaining, positive selection, 	Aravind L, Coggill P	pcc	Aravind L	Domain	The 'CABIT' domain (for 'cysteine-containing, all- in Themis') is found in a newly identified gene family that has three mammalian homologues (Themis, Icb1 and 9130404H23Rik) that encode proteins with two CABIT domains and a highly conserved proline-rich region. In contrast, Fam59A, Fam59B and related proteins from mammals to cnidarians, including the insect Serrano proteins, have a single copy of the CABIT domain, a proline-rich region and often a C-terminal SAM (sterile-motif) domain. Multiple-sequence alignment has predicted that the CABIT domain adopts an all-strand structure with at least 12 strands, ie a dyad of six-stranded beta-barrel units. The CABIT domain contains a nearly absolutely conserved cysteine residue which is likely to be central to its function. CABIT domain proteins function downstream of tyrosine kinase signalling and interact with GRB2.	20.30	20.30	20.30	20.40	19.70	20.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.67	0.70	-5.37	28	405	2010-02-01 17:20:35	2010-02-01 17:20:35	2	12	102	0	234	418	0	231.50	21	49.09	CHANGED	lPpll+.lp.puphptst............sphlhlpsstp..hpplh.....Apslpppp......hu.plpIPhsYpGpFchhsp..........FpoVp-l........uphhstplhspcshphp.....................s.t................phhlpp...G-plplh......................ttttctttthhp.......................slhshs.pssc....hlpLPhptcGpF.phhspp........paTlc-llc..phcLPhpVclssss.......sh.....t.hstl+Lhshhp-shllsssltpppps..............hclPhp...hplclhtscs..t.ststhhpthhp..p	......................................................................................sp.hhlpptt.........phhh.......hp..htp..tp..........ph.lP.s.Yt.G..hF+hhsp...............asos.-l........upths...c.lhsh..cshpht................................................phslpt...G-plplh.................................t.t.p.t..hhp............................................C.hh..shp..pppc.........tl.LPh.ptcG..pFs.phtstp..........................t.aolpplhp....hcLP.hsVpls.sts..........h...p.ht..h.t.hph..phh.cshlh..hpsh.p.t.h................hch..t...h..ph...pt.................p...................................................................	0	47	66	127
+12572	PF12737	Mating_C		C-terminal domain of homeodomain 1	Coggill P	pcc	Pfam-B_4610 (release 8.0)	Domain	Mating in fungi is controlled by the loci that determine the mating type of an individual, and only individuals with differing mating types can mate. Basidiomycete fungi have evolved a unique mating system, termed tetrapolar or bifactorial incompatibility, in which mating type is determined by two unlinked loci; compatibility at both loci is required for mating to occur. The multi-allelic tetrapolar mating system is considered to be a novel innovation that could have only evolved once, and is thus unique to the mushroom fungi. This domain is C-terminal to the homeodomain transcription factor region.	22.50	22.10	23.80	23.80	22.40	21.30	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.39	0.70	-5.59	20	42	2010-02-01 17:28:21	2010-02-01 17:28:21	2	4	13	0	7	43	0	402.90	27	65.73	CHANGED	sstlEsEFAuItupAcpLYp-KFspSpLAs+LDsAV+DhTPsLKtplpsc+p+++ppsp.pp..sp+ut+sYPoPEpSPss...uphhhSPsssslp.shspssspss++RcsSh...to-sccpsppssKRsRsssspsp...............p....uLPSPusSsh--Lsp.ssss.sosph.Pstsssss.................osKRKR+LSDu....thPAsKRPp.......RspslSDPhPh..tt.ss.spWhpthh.sssplhhhhslPsPVolhsPDss.........sP.............LDlplasFslh..hs.pssssssPsus...................ssspshsssslssssh.ssssssLD.shS.atsssasss......Lpsss.s..h..shP.s.ss......hsts..sh..........................hsshsssshshosLhspPssssssss....ulhssupso.ssssuLs...puphcAKp+ELcELcA+stALcAElA	..........shlEtpFAsltspAppLYspKFppSpLAs+LDsuV+DMTss.......l+tp.............hpp...c+tc..........ccpptp.pt........t.............p..........+A....t............csYPSPp..tSPsu...sphhhoPs.........s..ss.p.....ht.sts.h.......sp+RtpSh.....ssp.ptpsptssKR.Rp.shppp......................ssttsLPS...PssSt.-p.....s...ss.....ssh...sss.s.................shKRKRpLSDu....thPusKRsp......sRspssSDPhPh...tstpp..pa........sspl..hhslPsPVos.ssDss.........sP.............lDlplas.ashh.phs.psssh.sssut...................................s.pshplsuhsp.s.....s.tsssLD.shs.a.ssshs.s.............................lpssp.......shP.s.os......spts..sh...................................ssshshsslhspssssshsst........sl.s.upss.ssshsls........ppphpAKpccLctLpApstAlpAElu.........................................	0	6	7	7
+12573	PF12738	PTCB-BRCT		twin BRCT domain	Wood V, Coggill P	pcc	Pfam-B_181 (release 24.0)	Family	This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair [1,2].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-8.90	0.72	-4.11	49	1637	2012-10-02 11:51:29	2010-02-01 17:45:22	2	88	308	12	1119	4819	1157	64.10	25	10.14	CHANGED	lhlslouassp-....RptlpphlpthGupastsL.s+.....psTHLls...tpspGpKYctAppas.ltlVshpW	....................................hlsh.os.h.tspp.......+pplt.phspthGu.......p.h..p..ps..l..sp.........csT.H.L.ls....................tp..s...p......u.....p..K....ac..t...A...p........c......h........s...l..........lVsspW..........................................	1	356	574	889
+12574	PF12739	TRAPPC-Trs85		ER-Golgi trafficking TRAPP I complex 85 kDa subunit	Coggill P	pcc	manual	Family	This family is one of the subunits of the TRAPP Golgi trafficking complex. TRAPP subunits are found in two different sized complexes, TRAPP I and TRAPP II, and this Trs85 is in the smaller complex. TRAPP I, but Not TRAPP II, functions in ER-Golgi transport [1]. Trs85p was reported to function in the cytosol-to-vacuole targeting pathway, suggesting a role for this subunit in autophagy as well as in secretion [2]. The overall architecture of TRAPP I shows the other components to be Bet3p (TRAPPC3), Bet5p (TRAPPC1), Trs20p (TRAPPC2) , Trs23p (TRAPPC4), Trs31p (TRAPPC5), Trs33p (TRAPPC6a and b) and Trs85p.	25.20	25.20	25.30	25.40	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.55	0.70	-5.82	60	382	2010-02-01 17:51:56	2010-02-01 17:51:56	2	9	271	0	274	400	4	394.30	22	43.06	CHANGED	sop......s.s...sshpshtphhpphpphs..............P.ahpss..t..hh.halLlaDs....stsshppspplhpph+p.....phGh.psplLpl...............................tsppsh.s.t.........................s.assh.cph.t.t.t........................................................................................................t.tshhlshs-h.psl+shlp-hlspsllPa.........................ME+clphhs-plss.RKGl..ss+hhphs...+..+a...as........susssssssssts.............................................................................t.hYshsSsEttlR+LADhuFhLpDa.chAhosYchl+p..DapsD+AWpah.....AuspEMsu....luhhhss.p.s..............................tpp.hp.hl-s........Ah.sYhp........................................................................hp.....huhR.shllssEl....L...................pshsth.sust.hhchs......sc......pht........................pAllhEpsuhsa................................................................hps.ts.hh..thR.....KtuhahlLAu...................ccatpssphppAhpshppAhtlYs..........................................ttsWsthp-a............ltt	.....................................................................................................................tshpth.ph.tp.p.....................P.aht.s...ph..lc.halllHDt.....ttss.pp..........spthhcph+p.....phuh.pshlLpl............................t...sp.....pss.p.............................s.h.ph...pt......t...................................................................................................................................................................................................t.hssh.ls.pDh.sslc.shlp-hshptllPa.........................hE+plphhs-p.lss..........++ul...ssphh.hs.....+..+a...as...................ssptssts.ss.t......................................................................................................................................................................t.hYt.posE.hthR+luDhsFhlpca.clAhstYchh+p..Da..pDpAhhah.....Au..sh.EMsu....lohhhtsts.................................tp...t.hh-p........Ah.sYhs.........................................................................t......huhR.ssllhsEl..............l........................+spst..h..puss...hh+ht.......pp........tlt....................................................................suLlhEpsuhsa...............................................................................................................................................................................................hp..h...h...hR.....KhuhahlLAu...................ppatptsphppuhpshppAhtlap...............................................................................................................................................................	0	83	136	219
+12575	PF12740	Chlorophyllase2		Chlorophyllase enzyme	Coggill P	pcc	manual	Family	This family consists of several chlorophyllase and chlorophyllase-2 (EC:3.1.1.14) enzymes. Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyses the hydrolysis of an ester bond to yield chlorophyllide and phytol [1]. The family includes both plant and Amphioxus members.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.87	0.70	-5.50	21	87	2012-10-03 11:45:05	2010-02-01 17:54:43	2	7	51	0	43	2038	336	210.10	26	60.91	CHANGED	sPPKsLllshPsptGs..YPVllFhHGah.lhNsh.YoplhpHluSHGaIVlAPQ.................hYs........lhs...ssspcElpssAplhsWLsp...GLpshLP.....ss...VcPshp+luluGHSRGGKsAFAlALGh.ss...................plpaSAllGlDPVs.....Ghspstps.P.lLTa.pPpSFchs.hPshVIGTGLGs.t+.s.hhPsCAPsGVsHp-FasEC..psPshHFVApDYGHhDMLDDs.......shhu.thshshCKsGt...s+pPMRRFlGGlhVAFLpshlpGc.tscLpt	.......................................................................................t..............p.....p.....t..tt....a....PVllFh.p......G......hh......h........s....s.....h.....Y.....s.....p....l.....h.....p..H.......l..A...S.....a.G.a.l.V.l..usp..............................................................ht........................hts.........s.s...p.....p...l..p......h..h...t....l......h....s..W.....h.sp...........sL...p...s.......h.s...........................t....s...p..s......D........h......s..+.....l..ul..u.GHSpGGc...s.u.h.s.hs.htt....................................................................hp..s.l..h.hl-....P...s.s....................t............h....................h.sh....p.......h..t...s......h.Ps.hl..h..GoG..hu..............C....sstuhsat....pFapth..tssthth........h..tphG.HhDh..lcss.........................hC.ts..........hh....s..huh..............s....................................................................................................................................................................	0	17	35	39
+12576	PF12741	SusD-like		Susd and RagB outer membrane lipoprotein 	Coggill P	pcc	JCSG_target-390164	Family	This is a family of SusD-like proteins, one member of which, BT1043 (Swiss:Q8A8X4), is an outer membrane lipoprotein involved in host glycan metabolism. The structures of this and SusD-homologues in the family are dominated by tetratrico peptide repeats that may facilitate association with outer membrane beta-barrel transporters required for glycan uptake. The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide. Mammalian distal gut bacteria have an expanded capacity to utilize glycans. In the absence of dietary sources, some species rely on host-derived mucosal glycans. The ability of Bacteroides thetaiotaomicron, a prominent human gut symbiont, to forage host glycans contributes to both its ability to persist within an individual host and its ability to be transmitted naturally to new hosts at birth.	20.50	20.50	21.00	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	529	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.94	0.70	-5.92	5	684	2012-10-11 20:01:02	2010-02-01 18:05:50	2	5	145	12	136	1575	477	436.30	24	89.00	CHANGED	MKhpNIKshhph...LSlusLlLGusuCTuNF-.DINoNPhtlTc-DhchDshslGuhhssLpuuVl....s.pssocsNsYQlppsLsuDsauGYau.psTsFsuosNhoNYshsssWss..hlachlaosVYsshpclcphS..-socsPshYALApIlKVAAMHRsTDhYGPIPYSKl....Gp.sohsIPYDSQE-VYsuFFKELDEulplLs-plssupsu.....hpuhDhV.YpG.....cVpKWlKFANSL+LRLAIRIVpVcPuLAKEhAEKAVs.ppuGVI-sNsDNAch...sssshoNPLthIussWs......DTRMuADlhSYMsGYQDPRtAsYF-c.........s.thsssYKGlRsGIsl.ppK-sapsYS.......+PslosocPlhWMNAAEVsFLRAEG.ALRGW.NMGGTAp-LYEpGI+LSF-QaGl.sSuAsoYlADsTssPAsYTDPssscssAsAlSuITV+W-EGAopEEK.LERIITQKWIAhFPpGQEAWSEYRRTGYPKLlPVlsN..NSGGsIsos...sGlRRLPYPpoEYsuNupsVpcAV.uhLGGPDNGAT+VWWDKK	................................................................................................................................................hh.........................h......h...h................uC...t.....t..t...ap..phNp...s.........t.......s.............................t............t...........h.t..h....t...hh...................................h..Q.....h.......s.h...s.s....h...u...s..a..ht...........t.............s..t..p......s....s..a......s..............p....s.....a..t........h.a..p......t.......h......h..t....t...h..h...s.....t..h...p..l.......t.......................t......t....t......s.............h.....h......u...h.s..p......lh...cs...hhh...tp...h.sDhaG..s.lP..Y..s.ph............ut.....t..........t.....h....t....s....................Y.....D..s.pcp.....l..Y....p........t....hhp-.....L.sp...A.hsh...lp...t.......p.t..s.....t...............h.t...ph..D..h.l...a.t...G..............shppWh+aANSL+LRhAh....R...ls..........s....s.....s......t.....h....A.....p......p...........sp.....p..A...l.....p.............h......G...l.....h....p..s.s.s.........-........s...s.hh........................s....h....p.....N.....s.....h..........h....h..............t....as...............................-.....t....h....s....u...s...h.........s......h....h........t.....u......h....p............D........P.R...h.......h.h.....at.............................................................t.t....t....a.........G......h..................G......................................t....t.......t...........h...t.......t......h.S.............................t.........h....t......t.....s.....s...........h....h....h....h.psu..EshFLpAEu...ul..p....sa...sh.s...s...s.......A...p..s...h.Y...cp...Gl.........p........h.........S.......h.......p......p................h...........s...........h.........t..t....h.t.t...Y.h...t.............p.....t.....................t............................t.a........s..s.......................t.................................................s..t...h....s...............t......a......pt........s....s......s...............p...p..p..L-pIlT.QK..al..A......a.P.....u....E.u...Ws-h...R...R...T...G...Y.......P......p....h........h........s....s...h...s............s....s....s........l.sst.......................p......R.h.as.......s..t..p.t..s....t..t.h.t..t.uh....t..h.....L........s.........G...............D......p.h..sTclWWsh..........................................................................................................................	0	64	120	136
+12577	PF12742	Gryzun-like		Gryzun, putative Golgi trafficking	Coggill P	pcc	manual	Domain	Members of this family are involved in Golgi trafficking.	21.30	21.30	21.80	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.59	0.72	-4.16	7	7	2012-10-04 00:47:01	2010-02-02 09:42:44	2	2	5	0	6	116	1	58.60	26	9.76	CHANGED	th.pcs-lh....htV-...ScsFhhpG.pplphplhsGpcpch.asFhPLhsGh.hLPplsI	.............t....tscLl....lpV-p..sctFhlsGhs.phphpl..supphpl.apFlsLpsGhhhLPpIpl..........	1	4	5	5
+12578	PF12743	ESR1_C		Oestrogen-type nuclear receptor final C-terminal 	Coggill P	pcc	Willis S	Domain	This is the very C-terminal region of a subfamily of nuclear receptors that includes oestrogen receptors and other subfamily 3 group A members. The actual function of this region is not known, but the domain is absent from all the other types of nuclear receptors. Oestrogen receptors modulate AP-1-dependent transcription [1] through two distinct mechanisms: via protein-protein interactions on DNA; and via non-genomic actions. The mechanism used depends on the cellular localisation of the receptor. In addition to the more extensively studied cross-talk on DNA, additional non-genomic actions might be very important in target tissues in which membrane-associated ERs are found. These non-genomic actions probably contribute to the overall physiological responses mediated by ligand-bound ERs [2] and might possibly be mediated via this C-terminal domain.	22.00	22.00	22.60	23.70	19.20	21.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.09	0.72	-4.42	17	117	2010-02-02 09:45:35	2010-02-02 09:45:35	2	7	69	0	25	113	0	42.60	53	8.76	CHANGED	Pss+sus.hEEpspSQL.TouSTSuHSLQsYYls.pEtEsh.sTl	...PsuRuuushEEssQSpLuTsuSTSSHSLQsYYIs.tEsEuhPsTl.....	0	1	1	7
+12579	PF12744	ATG19_autophagy		Autophagy protein Atg19, Atg8-binding	Wood V, Coggill P	pcc	Wood V	Domain	Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. In contrast to autophagy, however, the Cvt pathway is a highly selective process that involves the sequestration of at least two specific cargos that are resident vacuolar hydrolases, aminopeptidase I (Ape1) and alpha-mannosidase (Ams1). These proteins are sequestered within a double-membrane vesicle, termed a Cvt vesicle. The Cvt vesicle is fairly consistent in size, and is much smaller than the autophagosome, being 140-160 nm in diameter. The prApe1 is sequestered within either Cvt vesicles or autophagosomes, depending on the nutrient conditions, and delivered to the vacuole. Autophagy and the Cvt pathway are topologically and mechanistically similar and share most of the same machinery. The Ape1 complex is ultimately enwrapped within either Cvt vesicles or autophagosomes at the perivacuolar PAS. The receptor protein Atg19 binds to the Ape1 complex through the prApe1 propeptide to form the Cvt complex in the cytosol. In the absence of Atg19, prApe1 can form an Ape1 complex, but does not localise at the PAS. Atg19 is a peripheral membrane protein with differing binding sites for both Ape1 and Ams1. The Atg8-binding region in the yeast proteins is this very C-terminal residues [3].	25.00	25.00	34.90	32.90	21.30	21.20	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.57	0.70	-5.11	10	35	2010-02-02 09:48:03	2010-02-02 09:48:03	2	2	24	6	16	35	0	228.10	40	50.46	CHANGED	tsIplPED+PELlsFFo.....clcTscQLp-VaptY+sYE+LhQchDupch+h..h....T.huoscuhKphsIphE........ssPN-cLLplphup+DNSLaFpLaNpTNplluGNCpLcF.....psooQIp..h.IcMGPHEIGIKpaKEhha....FPpsho.hussTh-lVNQDGElIhlGKhusSs.IsL+sP.uphSstShQsu.....Q-Ps.sFcsDoLsp.D-SSIlSTshshphD.....Gss.p+shTWEEl	......................................................s.sIplPED+sELlsFFo.....clcTspQLp-VaptY+sYE+...L.QchDuc.............T..huuscuhKptpIp.E.........sPN-tsLplshsp+DNSLaFpLaNpTNpllsGNCpLcFp......spsooQI......IcMGPHEIGIKphKEhpa..............FP.thsh.us.Tlcl.N...Q.G-VIalGKh..u...s..S.s..IsL.+....sP.uphS....sp.ShQsu...........Q-..Ph.sFphD.sLsp...D-S.SIlSTohohphD.......Gss.p+sh.TWEEl............	0	2	7	12
+12580	PF12745	HGTP_anticodon2		Anticodon binding domain of tRNAs	Wood V, Coggill P	pcc	Pfam-B_20896 (release 24.0)	Domain	This is an HGTP_anticodon binding domain, found largely on Gcn2 proteins which bind tRNA to down regulate translation in certain stress situations.	21.00	21.00	21.10	21.10	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.66	0.70	-5.25	30	206	2012-10-02 17:25:11	2010-02-02 10:11:00	2	13	179	0	150	351	11	226.00	26	14.78	CHANGED	W+spRCDVLVuSFssslLcosGlcllppLWupsISADl.hcss.ShE-llsphppDGhsWIVllKQ.................................t.csp.+sLKVKslsppc..DsDlc.h-EllsaLcsEl.....pt.+p..pcptssspsp.hppsspptsshss..........................pppslhl.sstsRuK.KsN++spW.Ehc.tAptuoppllcshh.....suPIhAlDs.RDElL-hIphToLu.pt-pW.R+Vhts.ssss.RpYsspIastLt..+pts+up+...........hAhlYshRTGcsslhDLp	......................................p+CDVLV.sShss...ss.L.o.pulpllppLWstsIoA-lhh-..s...s.......S....E-lhptsp..ccs.hsallll+p....................................sut....lK.VKslppcc.....-h-..l..p...ts..-Llsalppcl...........cp.+......pctt..t...t..t.....t..s...s..s...........................t.....l.l.sstp.h..ut.p.p.+R..h....p....h..t.tplhpp.......p.h...lhsl-h.p-plh.phl..p.....p....hs.p.pta....pplht.......hs.h.+.p.ahttlhp.l.......p.tt...c....t.............hhlas.h+ss...............................................................................................................................................	1	41	80	119
+12581	PF12746	GNAT_acetyltran		GNAT acetyltransferase	Coggill P	pcc	JCSG_pdb_2jlm	Family	Many of the members are annotated s being Zwittermicin A resistance proteins, whereas others are listed as being GNAT acetyltransferases.  The family has similarities to the GNAT acetyltransferase family.	20.60	20.60	20.60	20.60	20.50	20.50	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.64	0.70	-5.57	2	486	2012-10-02 22:59:21	2010-02-02 13:52:51	2	2	325	2	48	433	12	231.20	31	95.29	CHANGED	Mh.ph.....cphsphFtDaspsllhohLpGhMGshaVsD.p.PpsA.hhhG...hFsFhAGps+....c-LL+.h.s+.hllV.ps.pWpchlEshYtctIcpFhRYthK+ssE.FDhu+LQpLlssLPcua-h+RIDcNlhpsshlcchS+Dhsupa.sVEpalshGlGYsILaKGpVVsGASSYu.YssGIEIEVsTccsYRthGLAphsuAtLILsCL-+GlYPsWDAtshTShKLAEKLGY.hDKsYpsY...........p.p	.........................................................................................................................................................................................hlh....hl...p.u...h.Gp..lah....ss.......p..s..ssh..h.....h.G.......aha..h..uG....p.....s...........p...............p....c.h...h.......p....t.........h.......t.....p.......t.....h....h.............l.............l.....s....ps.......p...p.W..pphl......c.p..h.....h.p.p......t.l...pp...............hs..Rht...a...p.p..psp........F.p...p.t...hpp...h....s.p.l..p.sYp..........lp.ID.p.ch.hpp.........t.....p..c.....a....o...p....-...h........hs.p.a..p.S.h.c.s.F.....l.p..........t.G.hG....as...I.l..h..s..s..p..l.l...u.s.ssS.hh.s..a.p.st..h..EI-.ls..T.c.sa.pscGLA.ptluuth...I....h....-CL....p.....p...s...lh...P...t...W...D..s..c..N..h..s..St+lAcpLGaphstsYpsa..............h....................	2	21	36	42
+12582	PF12747	DdrB		DdrB-like protein	Bateman A	agb	Bateman A	Family	This family includes the Deinococcus DdrB protein which is a ssDNA binding protein. This family also includes some possibly distantly related cyanobacterial proteins. However, these are not strongly supported. The structure of DdrB is known.	25.00	25.00	33.70	33.50	21.40	20.00	hmmbuild  --amino -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.64	0.71	-4.41	6	17	2010-02-03 15:48:23	2010-02-03 15:48:23	2	1	11	5	15	19	0	133.50	37	80.75	CHANGED	M............pl.ahss.hsKsThsl..tshLhDVpcthsR.s..................hosuE..sssYQaPL-p.hsFDWshIGAR.chossEGtplV.aRG+uacRRc.pssD....KhsAAIhFSpusKs.........sDG-hc.YlpLhhFRstp	.....................................pl...ss.hscsohpl...s.Lh-Vpphhup.s..................hoss-.sssGaphPLspttsFDWshIGAR.hhossEGtphV.a+G+sa+RRcLpssD....cLPAAlKaSRGAKs.-.....chsDGchc..YVoLhhFRst........	0	1	9	15
+12584	PF12749	Metallothio_Euk		Eukaryotic metallothionein	Wood V, Coggill P	pcc	Wood V	Family	This is a family of eukaryotic metallothioneins.	21.80	21.80	22.50	21.80	21.20	21.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.49	0.72	-11.35	0.72	-3.94	4	26	2012-10-05 18:33:37	2010-02-03 17:50:25	2	2	15	0	5	61	0	67.00	50	92.47	CHANGED	Mtt.sp...TpsChCsss.....CpCG..csCsCp.....stCGCssCKs......................uC+CSusssssCKCT...SCpCpp....p	......Mss.spsh.TssChCs.ssps..t.hC+CG..cACpCt.....ssCuCs.sCKs....uC+Css.s.ps.ssC..cCoustsC.Ctp.t.......	0	4	4	4
+12585	PF12750	Maff2		Maff2 family	Bateman A	agb	Jackhmmer:Q187G1_CLOD6	Family	This family of short membrane proteins are related to the protein Maff2. Maff2 lies just outside the direct repeats of a tetracycline resistance transposable element. This protein may contain transmembrane helices.	27.00	27.00	29.30	29.30	26.70	26.20	hmmbuild  --amino -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.41	0.72	-4.45	7	359	2010-02-04 13:16:13	2010-02-04 13:16:13	2	1	171	0	29	229	33	58.10	69	94.26	CHANGED	MtFFsSAlssLpTLVlALGAGLuVWGVINLLEGYGsDNPGAKSQGlKQLMAGGGlhLIGhTLlPLLSuLF	......MtFFspAVsVLpTLVhAlGAGLGlWGVINLhEGYGNDNPGAKSQGhKQLMAGuGlhllGh.LlP.Lushh.....	0	23	29	29
+12586	PF12751	Vac7		Vacuolar segregation subunit 7	Wood V, Coggill P	pcc	Pfam-B_10847 (release 24.0)	Family	Vac7 is localised at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance [1]. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway [2]. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.	25.00	25.00	32.90	26.00	22.70	22.40	hmmbuild  --amino -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.56	0.70	-12.54	0.70	-5.61	7	172	2010-02-04 17:05:01	2010-02-04 17:05:01	2	3	110	0	128	174	0	228.40	26	39.02	CHANGED	IVETETVSSIPQVuLGsGsGERGsuuRsD.uGolRhKsSsETIRP+KEKKKo.RKPsA.LssGssSSKADIFEAKVASAVDEADsSDS-ETFVYESNPPDsaPsRp.RYHSRTPSATSMASQsDQhuGRoRhuhRDs.HulTGKRSMKFTNs.sY..uol-GDh.spcsu+upuRss.Gp.sHTsRHHHIGR.HGR.us...aPSLFDs-SPFspSQ.p.+SsRHalusuhRQupp....R.sssNYRoh.susKKsG-.YsYDFD.uEGADDERTPLVGSs.RssRSRpG.RRPNSASLRQMEYMppRpRShFuRYGhChllhlLlllllGGAToFllulh+PLlDVpVhtIQNVLASEQEIMlDLpVpAlNPNLhsloIsDMDVNIFAKSRYVGoDph.WR	......................................................................................................................................................................................................................................................................oKsDhF.tA+lAsA..Vs-sp.SDStE.....T....FlY-sss..p..............................................................................................................................................................................................................................................................................................................................................................................................................................................................h........hh..h.h.hshhhu..p.L.thtl..hpp.lsSpt.lhhsh.htAhNsshhslsltthphplFA+S.a..............................................................................................................................................................	0	24	64	111
+12587	PF12752	SUZ		SUZ domain	Aravind L	agb	Aravind L	Domain	The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.	27.00	27.00	27.30	27.30	26.80	26.80	hmmbuild  --amino -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.07	0.72	-3.44	57	527	2010-02-10 14:08:56	2010-02-10 14:08:56	2	8	208	0	305	471	0	58.00	34	9.30	CHANGED	ptsphpIh+R....................Pstsssps...............tssspsttsptscolEEREtcYpcARpRIFusss	.................................phhIL+R.................................sttsssss.........................tp..pss.pss..ptsKSlEEREpEYpcARcRIFupt.s.............	0	78	133	211
+12588	PF12753	Nro1		Nuclear pore complex subunit Nro1	Wood V, Coggill P	pcc	Pfam-B_4826 (release 24.0)	Family	In fission yeast, this protein is a positive regulator of the stability of Sre1N, the sterol regulatory element-binding protein which is an ER membrane-bound transcription factor that controls adaptation to low oxygen-growth [1]. In addition, the fission yeast Nro1 is a direct inhibitor of a protein that inhibits SreN1 degradation, Ofd1 (an oxoglutamate deoxygenase). The outcome of this reactivity is that Ofd1 acts as an oxygen sensor that regulates the binding of Nro1 to Ofd1 to control the stability of Sre1N [2]. Solution of the structure of Nro1 reveals it to be made up of a number of TPR coils [3]. TPR proteins are composed of three to 16 tandem peptide repeat motifs of 34 amino acids with degenerate sequence. The helical pairs adopt a helix-turn-helix anti-parallel arrangement with interacting helices. In general, TPR motifs are stacked together so that helix A from TPRn is packed between helix B from TPRn and helix A from TPRn+1. In Nro1, the 12 alpha helices forming the six TPR motifs are organised as follows from N terminus to C terminus - TPR1A, TPR1B, TPR2A, TPR2B, TPR3A, TPR3B, TPR4A, TPR4B, TPR5A, TPR5B, TPR6A, and TPR6B with the C-terminal helix (hC) running above the sixth TPR motif with an angle of approx 45 degrees with TPR6A and TPR6B. The corresponding TPRs structural motifs are longer (50 residues) than are canonical ones (34 amino acids) and are organised into two subdomains - Nro1-N (residues 55-225) and Nro1-C (residues 226-393). The Nro1/Etti protein plays a role in nuclear import suggesting that it is residues 4-19 that are interacting with Ofd1 [3]. 	20.80	20.80	21.00	20.80	20.50	20.20	hmmbuild  --amino -o /dev/null HMM SEED	404	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.31	0.70	-5.52	18	53	2012-10-11 20:01:03	2010-02-10 15:57:53	2	2	46	5	37	55	0	357.50	36	97.70	CHANGED	M.A..KRsLGLGKts+tKKpKh.............psspsscpsss....ssplpVELsEthDs-DEluQL+uLWcsYhcS-+DsEl.....llNGIlHECDRLLRpp...............pp-cth........pLsc.FHuIYALALuELshF+st-pp.............plppaF.DsALERs-lG.hpphscS.hLhlspuKIllp+IPLpYISpLss-Spsp....pl.p.L-pAhpsaphsppphp............sh-lLphlDDLLDIl-NFG+c.pp.pEs.DsD-......t-t.-..plcLscpHPLYtlpps.t.N.pWhR-phlthLsslpc...........................spLhRpls++LGQsYLpcAE.PosVFsoLpYD-..t.ps.cp.hph..tcpAQchAppLhccAlcYLccAcs........---P-TWVslAEAhIsLGNLa-s-ScEQEchYpcAEcILpKANpATpGKYcDlL-NLL	........................................................MA..KRsLGLGKts+tKKpKhpp...........ppppsstpsss......pspholEL..s--sDh-DEluQL.......cGLappYhpS-+DsEh.................lLNGIlHECDRLLR.p...............-ppp...........pLss.hFauIYAlALuELshF+st-pc.............plppaF.-sAlERl-hG.Lpphscs..LhlshuKIlhp+IsLpa.ISpLplcScsp.....phcl..p.L-puhctaphh.cpcsp..........................sh-lLp...hlsDLLDIl-NFG+c.pp.p-s..Dp-s......................---.c...plcLp.pHP..la.lpps.phs.pWhRpph.phlcshpp...............................plhtplspplGp.YLpcAE.PsplahsLpY-c..t.tt.pp......pshptppuQchA.chhppAlcYLcpAp.........c--P-TWVplAEAhIsLGNLh-.-StEQEchYppAEcILt+ANpuopGKap-lL-Nl..............................	0	12	24	36
+12589	PF12754	Blt1		Cell-cycle control medial ring component	Wood V, Coggill P	pcc	Wood V	Family	During size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1, Blt1 has been shown to co-localise with Cdr2 in the medial interphase nodes, as well as with Mid1 which was previously shown to localise to similar interphase structures. Physical interactions between Blt1-Mid1, Blt1-Cdr2 and Cdr2-Mid1 were detected, indicating that medial cortical nodes are formed by the ordered, Cdr2-dependent assembly of multiple interacting proteins during interphase. Q5KIH8.1/10-346; Q5KIH8.1/10-90;	27.00	27.00	37.10	29.50	21.10	26.60	hmmbuild  --amino -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.04	0.70	-4.83	29	75	2012-10-03 10:59:06	2010-02-10 16:13:33	2	2	70	2	62	73	0	210.10	38	91.22	CHANGED	Fs.....................................KSFLuuLDS..........................RPlKLs....................................................uDaVhDPcshshpsP.................YTLPRLps.PHP......................................MPKKh...............................KpstsPGSSKSIolp....................LKSARNPsLcloLsNs.sluo.............................TSVp-LK-sVppRl.ssp...........ssplPlDKIK.....ILaK+KPV...sucTlu-lLus..-sthluGGcElEh.GVMIhGGA.pls.s...........................................tttttttp.pp.hss.....ss.u......so...................uppVltTEtFW-D...............................................................................................................................................LpuFlpp+lK.DttpApplpsl..F+tAWpus	.....................Fs.KoFLusLDS..........................+PlKLs....................................................uDaV.DPcsasspsP.................ahLPRhss..+........................................................MsKth...............................ppshsPGo..s...+S...IoVp....................LKSs.RNP.sL.clsLssh.slso.............................TSl.-lKpsVpp.................psplPlDKlK.....lLap+KPV...suKolt-lL........us.......su.spplEF.uVMlhGGAssh..ss....................................................t...t.........................................s.tllts-tFWtD...............................................................................................................................................Lpsah..+l+.s...utph..h..F+tuW.t.t...................................................	0	10	28	48
+12590	PF12755	Vac14_Fab1_bd		Vacuolar 14 Fab1-binding region	Wood V, Coggill P	pcc	manual	Domain	Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.18	0.72	-3.60	35	386	2012-10-11 20:01:03	2010-02-10 16:22:32	2	28	266	0	281	523	5	95.30	42	10.54	CHANGED	NtRpGGLIGLAAsuIALGpc......sspalcpIl.PVLsCFsDpDsRVRYYACE......SLYNIuKVu+uplLh..aFN-lFDsLs+.....LsADsD.sV+sGAcLLDRLlKD	.....................tRpGGLlGLAAsuluLupc..........sstYLccll.PVL.sCFsDpDsRV.RYYACE......uLYNI.s.KV.u...+.G..c....l.Ls....aFNclF.DuLsK.....................Ls.uDs-.s..V+suA.EL.LDRLlKD...................................	0	99	154	226
+12591	PF12756	zf-C2H2_2		C2H2 type zinc-finger (2 copies)	Wood V, Coggill P	pcc	Pfam-B_88 (release 24.0)	Family	This family contains two copies of a C2H2-like zinc finger domain.	21.70	10.00	21.70	10.00	21.60	9.90	hmmbuild  --amino -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.23	0.72	-11.09	0.72	-3.90	112	2196	2012-10-03 11:22:52	2010-02-10 17:43:06	2	245	346	2	1419	5276	41	77.00	18	19.96	CHANGED	p..CLFCspp.....ss.hc.......pslpHM......hppHuhalP...-pcaLs..DhpGLlpYLtcKlsh......tphClhCppp.tp...ohpul+pHM..psK.sHs+lsh..csptp....h-hscFYDa.psshs	...........................................................................t...................................................................................................................................................................h.t.........................................hpChh......Cspp...ap....................ohp..s..lptHM....p.p..p...t...Hh.t.........................................t.....................................................................	2	388	637	1011
+12592	PF12757	DUF3812		Protein of unknown function (DUF3812)	Wood V, Coggill P	pcc	Pfam-B_8029 (release 24.0)	Family	This is a family of fungal proteins whose function is not known.	25.00	25.00	31.90	31.90	20.00	19.60	hmmbuild  --amino -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.35	0.71	-4.15	39	146	2010-02-10 17:51:15	2010-02-10 17:51:15	2	1	115	0	106	150	0	123.70	26	14.39	CHANGED	spssLhpsApcNscsplpsh-pcshtp..............shphppchpcpAlttAppp.....tptppppssplslG......GGhals.s-l-slApphlpPsLc-Isc+A.......-tpRsp-h-t+hcpcctccptppt+pcEcct+p	..................................pttlhttApcssptpLpsl-pcshtp....................th.p-apppAhthAppp......................tptpppspsplslG......GGhahs.p-lsslApp+lpPlLs-Is-+A.......cppRtc.......-tph+hcpcctccptppt+pc-cphc...................	1	17	53	90
+12593	PF12758	DUF3813		Protein of unknown function (DUF3813)	Mistry J	jm14	PfamB_1273 (release 24.0)	Family	This is an uncharacterised family of Bacillus proteins.	25.00	25.00	45.30	26.00	24.10	24.70	hmmbuild  --amino -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-9.17	0.72	-3.83	4	128	2010-02-11 10:51:27	2010-02-11 10:51:27	2	1	128	0	17	59	0	62.90	68	92.96	CHANGED	MtNpLaQpA+shVpphlSpuuus...EQQpsl.+AKNAlpSAYANSosAE+pQL+phQ-QLppls	...MGNLLFQQARDAVtsAVSCS.S.Gs.......EQQ-L....VYRAKNALpSAYANSSTAEKVQLREMQEQLQsIp...	0	1	9	11
+12594	PF12759	HTH_Tnp_IS1	InsA_C;	InsA C-terminal domain	Bateman A	agb	Bateman A	Domain	This short domain is found at the C-terminus of the InsA protein. This domain contains a helix-turn-helix domain.	21.70	21.70	21.70	22.00	21.60	21.60	hmmbuild  --amino -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.20	0.72	-4.53	4	1328	2012-10-04 14:01:12	2010-02-11 16:39:48	2	7	456	0	75	676	9	42.40	62	42.85	CHANGED	YoYcAppPGhKEpIl-MAhNGAGsRhTARsL+IGINTVlRTLKNSR	..........aTYsAsQP...Gs+p.KIIDMAM.NGlG........sRsTARl.ht.VGlNTll.RpLKNSt............	1	16	31	61
+12595	PF12760	Zn_Tnp_IS1595	Zn_ribbon_3;	Transposase zinc-ribbon domain	Bateman A	agb	Pfam-B_3 (Release 24.0)	Domain	This zinc binding domain is found in a range of transposase proteins such as ISSPO8, ISSOD11, ISRSSP2 etc. It is likely a zinc-binding beta ribbon domain that could bind the DNA.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  --amino -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.85	0.72	-4.15	73	764	2012-10-03 10:42:43	2010-02-11 17:07:24	2	7	279	0	235	786	170	47.70	34	15.88	CHANGED	ssEcpstphLpphRWssG.....hs.CP+CGsp...chaplps.........tthapCpp..Cp+p	...............s-ppChphLpphRWPpG.......hs.C.P+Cusp...tthphpp...............pph..a.pCps......Ct+p..............	0	51	128	153
+12596	PF12761	End3	E3;	Actin cytoskeleton-regulatory complex protein END3	Wood V, Coggill P	pcc	Pfam-B_51079 (release 24.0)	Family	Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release [1]. End3p is part of the coat module protein complex Pan1, along with Pan1p, Sla1p, and Sla2p [2]. The proteins in this complex are regulated by phosphorylation events. End3p also regulates the cortical actin cytoskeleton [3,4]. The subunits of the Pan1 complex are homologous to mammalian intersectin.	25.00	25.00	25.80	25.00	23.80	23.30	hmmbuild  --amino -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.44	0.71	-4.66	21	129	2010-02-11 19:37:22	2010-02-11 19:37:22	2	5	114	0	90	124	0	172.20	38	48.58	CHANGED	sKDtsLsFLHILNQRcc.GhRIPRsVPASLRAoFpKpp.sYsLs......pspsph.tssssssTss.pKtpFu-sYLs+l...Ghusp..........shp...ppGTDFSu.spsoDWEEVRL+RELA-LEshLscspptscsp.........spsspsp.uLlKcEhEQLLcYKccpLpphp...spussutsLpsl+cDlchlcpQVssLcpaLps+pppLpcLcp	............................sKDssLsFLHILNpRc-.GhRIPRslPASLRuoFppsplsYplcs.........tstpph.tsptsspTsou..pKtpFu-tYLs+lGhus.............pstGTDFSs...psp-WEcVRL++pLt-L-pclptspttsppp..........ttpstsp.sLlKc...Eh.QLLcYKccpLpchpp..ucsptutsLcplp-DlpslppQV-sLcsaL...tp+pp.LppLp.t..................................	0	16	44	76
+12597	PF12762	DDE_Tnp_IS1595	Transposase_38;	ISXO2-like transposase domain	Bateman A	agb	Pfam-B_3 (Release 24.0)	Domain	This domain probably functions as an integrase that is found in a wide variety of transposases, including ISXO2.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.74	0.71	-4.38	78	1888	2012-10-03 01:22:09	2010-02-12 10:55:34	2	15	595	0	571	1721	293	125.10	25	51.91	CHANGED	hLsG..........VE.........lD-sYl..GGcp....p......sp......cG+.......s........t..ssKssVlshl-ps...................t.sh+shstll.ts.hstpsltshl....pctlptsuplhTDphssYsslstt..asHpplsastp......hs.......tt.....sshshlcshhuplKRtlhGsaHtlu.scaLppYlsEhsaRaN	.........................................................................tG......lp........hD-s.hh.....utpp............................tp.......................tG+.......s..............................................ttKh..lhs..hlcps.......................................pshh.hl......ss..hpptsl...h..l...............tpp.lp.s....s..uh......l.h..o.D..s..htu..Y.p.....t.L........p............t...t........a..t.......H.......h........t...l.spu...tp.............s.......................pt........phphlps.hhs.p.hKphl..t....t.aps.ht.tchh........aLtch.a+.................................	0	221	343	458
+12598	PF12763	EF-hand_4	efhand_3;	Cytoskeletal-regulatory complex EF hand	Wood V, Coggill P	pcc	Pfam-B_51079 (release 24.0)	Family	This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.43	0.72	-4.29	13	2526	2012-10-02 16:17:27	2010-02-15 09:18:54	2	126	302	12	1472	3070	25	94.90	32	17.53	CHANGED	MP...+LE-aEIKKYW-IFpGLpPtsNKLoGDpVuPVLKNS+LssDQLu+IW-LuDIDsDGpLDFEEFCIsMRLIFDlVNGshssVPscLPsWLVPuSKAHLIQANc	...................................hht.............p.ap.p.lF..p...s.h....s..s..h..s.....G..h..l.oG.s.p.A....+....s.h...h..h....p.....S....p....L..P..p..s.h...L...u..c.........IW....s.............L....u..Dhcp-G..tLstpEFs..l...AM.+.Ll...........h..h..p..t................................lPt.L.Ps..t.hh..............ttt...............................	0	408	686	1107
+12599	PF12764	Gly-rich_Ago1		Glycine-rich region of argonaut	Coggill P	pcc	Pfam-B_7248 (release 24.0)	Domain	This domain is often found at the very N-terminal of argonaut-like proteins.	25.00	25.00	34.20	33.60	24.10	21.10	hmmbuild  --amino -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.60	0.72	-3.39	12	50	2010-02-15 11:44:43	2010-02-15 11:44:43	2	2	30	0	16	50	0	101.70	50	14.75	CHANGED	GGs.EYpsp...GRGsPP.Q..GGpsth.GGGpuGu.......Pss.....s.R.ssPELHQAT...pssYQA.hss.PhP........SEsusSstP.spsssh..tQQFQQLolpQtu.oSQAIQs.Pu	................GGP.EYQuR.....GRGG..Ps.Q..........GGtsta..GGGRGGu.............PSu...ssP.Rp..oVP.ELHQAT...pss.YQA.VsopPos........SEsusophP..scssss..tQQFpQLulcpt.u.sSQAI.QPhPs......	0	1	8	13
+12600	PF12765	Cohesin_HEAT		HEAT repeat associated with sister chromatid cohesion	Wodd V, Coggill P	pcc	Pfam-B_443 (release 24.0)	Family	This HEAT repeat is found most frequently in sister chromatid cohesion proteins such as Nipped-B. HEAT repeats are found tandemly repeated in many proteins, and they appear to serve as flexible scaffolding on which other components can assemble.	21.00	8.90	21.00	8.90	20.90	8.80	hmmbuild  --amino -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.61	0.72	-3.95	52	424	2012-10-11 20:01:03	2010-02-15 11:48:56	2	36	262	0	276	589	36	37.80	32	2.43	CHANGED	+slstllptDsslLsps....plppslpp+htDsussVR-Asl-Ll	....................+sl..hlthDsplLst................ph.phlpp+h.tDsu.ssVR-AAlpLl....	1	90	146	220
+12601	PF12766	Pyridox_oxase_2		Pyridoxamine 5'-phosphate oxidase	Wood V, Coggill P	pcc	Pfam-B_2486 (release 24.0)	Family	Pyridoxamine 5'-phosphate oxidase catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP), the terminal step in the de novo biosynthesis of PLP in Escherichia coli and part of the salvage pathway of this coenzyme in both E. coli and mammalian cells. This region is the flavoprotein FMN-binding domain.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.53	0.72	-3.69	60	319	2012-10-02 11:35:36	2010-02-15 12:53:17	2	6	304	4	186	1478	2504	100.10	30	42.69	CHANGED	huPW+shlppulcp......p..ssphhQLATls.s.ssp.....P+sRTlVFRGFhtp..............................ssshLphsTDtRocKlpplt...............p..ssts..EhsaaascotcQaRlpGpshlls	..................................h...Wt..htpulpp......t..s.phhpLATls....sup..................P.csRTlVaRuahtp...................................................................................................................sshLphpTDtRSpKltclt.......................p.sshsEhs.a..a...h..........s...........c...........stp...QaRlpGpstll.s........................................	0	55	111	157
+12602	PF12767	SAGA-Tad1		Transcriptional regulator of RNA polII, SAGA, subunit	Wood V, Coggill P	pcc	Pfam-B_319 (release 24.0)	Family	The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II [1,2]. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA [3]. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.	27.80	27.80	28.10	27.80	27.70	27.70	hmmbuild  --amino -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.61	0.70	-4.71	65	356	2010-02-15 13:09:22	2010-02-15 13:09:22	2	11	232	0	254	344	0	212.60	22	55.99	CHANGED	hs.....tstRl-ltpl+pplhptlG.cphpcYhptLstFlh..............s+lo+pEh.sp.sptll.................spcp.....l+LHNpLlhuILsNu....htps....ss...ss...............................tptp.hstsssh..ssptspp.pphccphht.s.csptchpth...............................................t.t.t.....ssh.....tth.chs.hpstpphpph......................ppp.............................h.tt...shsscohpLPDspsLptRh.hhshcpGL........sulstssspllshuL-saLKsllpuslshsp	..........................................................st.......t.-lt.hhppltptlG....cphppYhttlphalh.............................t+ls+pEasp.stthL.......................................stcp...........l+LHNphlhuIlsss....tp........Ps...ts.............................................ttt.s....s....s..h..tst.ts.p....hptphh........ptph.ht..............................................................h.............t....ph.....hptspp..t.....................................................................................................................................................................t....h.s...cs.htLP-..ttplptRh..hs..hcpGL..........ssss.pssphlshul-salKpllpsshshht.................................................	0	71	137	208
+12603	PF12768	Rax2		Cortical protein marker for cell polarity	Wood V, Coggill P	pcc	Pfam-B_2071 (release 24.0)	Family	Diploid yeast cells repeatedly polarize and bud from their poles, due probably to the presence of highly stable membrane markers, and Rax2 is one such marker. It is inherited immutably at the cell cortex for multiple generations, and has a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means of coupling a cell's history with the future development of a precise morphogenetic form [1]. Both Rax1 and Rax2 localise to the distal pole as well as to the division site and they interact both with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical markers for bipolar budding [2]. thus Rax2 is likely to control cell polarity during vegetative growth, and in fission yeast this is done by regulating the localisation of for3p [3].	25.60	24.90	25.60	25.20	25.50	24.60	hmmbuild  --amino -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.89	0.70	-5.19	34	157	2010-02-15 13:49:32	2010-02-15 13:49:32	2	7	131	0	124	169	15	251.50	25	23.26	CHANGED	lhVGGsFppAGuLsCsulChashssspWspPuss......lpGsVsslpah..ss.spLlluG.sLTlss.sssslsoYshpspsapshtu.sp..t.ls.uslsuhshhtsDtsphhlsGp..upGssalhta...DGopWpphss.lhts..sTsIpulpllsL..s.ps+pp...sshhsssplLlloGplsl.sca..GpsSuALasGo..shhPalloo..................p...ssspsGslsplFhp..............................ssssaps.p....h....cphupG...hVVLIuhuhALGsshLlslhGlIhshhpp+ppthh.sspt.th-csp.hpplPP	..............................................................lhVGGsF..p.p.A...G..u.Ls.CsulCha.shssspWsp.Gss.......lpG..s.V..ssltas...ss..spLlluG.shs.....lss....s..sst......lApashpsp.s..Wsshsu.s...ttls.Gs.l...suhshstpsss...p..hhhuGp......s....s....u...ss..alhta...cGs.pWpsh...st..hhts...to.lpslphhsl..p...psctt...tshhspsp.hLhlsGpl.l.ssa..G...ssuslasGs..shhPahlos..................p...ssspsGt.hstlF.p....................................pp..hpt...............phhshG...hVVLluhslALGhh.....hllslhGllhshh.+c.ppt...h..t....hhpc...hptlsP................................................	0	45	77	109
+12604	PF12769	DUF3814		Domain of unknown function (DUF3814)	Mistry J	jm14	Pfam-B_10 (release 24.0)	Family	This is a domain of unknown function.  It is often found in combination with Pfam:PF05222, Pfam:PF01262 and Pfam:PF02233 on alanine dehydrogenase and pyridine nucleotide transhydrogenase enzymes.	25.00	25.00	30.30	30.30	22.90	22.90	hmmbuild  --amino -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.07	0.72	-3.82	159	2249	2010-02-16 09:34:05	2010-02-16 09:34:05	2	12	2099	0	638	1524	1931	86.90	57	21.39	CHANGED	lttlslFlLAshlGa.VlhpVsssLHTPLMSsTNAISGIllVGAllth..u.............................hsplLuhlAlhlAolNlsGGFhVTcRMLpMF++	......h..phslFsLAshVGYaVVWsVo.ALHTPL....MSV.TNAISGIIlVGALLtlGpu...........................tshsphLuhlAVllAoINIF..GGFhVTpRMLcMF+K.........	0	187	373	522
+12605	PF12770	CHAT		CHAT domain	Bateman A, Rawlings ND	agb	Pfam-B_4 (Release 24.0)	Domain	These proteins appear to be related to peptidases in peptidase clan CD that includes the caspases. This domain has been termed the CHAT domain for Caspase HetF Associated with Tprs. This family has been identified as a sister group to the separins [1].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  --amino -o /dev/null --hand HMM SEED	287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.14	0.70	-5.28	82	1893	2012-10-03 02:24:44	2010-02-16 10:52:24	2	520	555	0	959	2220	184	278.30	18	28.37	CHANGED	ptsuppLaphLlt.P.lttt..l.........tshp...pLllssDu......sLptlPhtu..Lhssp.........................paLlEc...asls..hhsShp....Lpphp.tshpstps..........Lshussphs......t........................................................................................................................ssLPusttE.hpslsph.............hhts..............pshhsppu..Thpslppth...........pphpllHlATHu.Fp.........................................ss.tpShlhLt..................................................ssthLshp-ltp..l....sLst...........scLllLSACpTu..........hG.........ss-uhhG....lstshhhAGspusluSLW.VsD..puTttLMppFYppLtp.......shttucAL+pAQlthhpsphh..................................................pc.PaaW...........uuF..hhhGs	.................................................................................................................................................................................................t......h.p.h.h.......s..h.t....l........................................thp..........plhh.h.sps............Lt.lPhth......l.stp.......................................................thlhp.p.......h...lt.....hhss.h..p..........hh.th..t.......tt.t..................................................hhh.u..ssp.................................................................................................................................................................................................................sLs.t.st..tE...h...ptltph.....................................ht.t.........................phh.ht.p.p....s.....ot..p.plhpth.....................pphp..ll..HhAsHGths...............................................................................................tt.s...p.u..tlhlt..............................................................................................tsthLs...h.p.-lhp....h......plpt.................spL..llLSA.Cpou...........................................................hst..........tsc..t..h...h.u..............Lspuhl.t.u...G..s.ps.Vlu...o..h..W..t..VsD...........pss.tt.hh.......pt..FYp.p.Ltp..................shshs.p.....A...L...p..pA.phthhpt...........................................................................................s..W.......ush.h..............................................................................................................................................	1	381	710	898
+12606	PF12771	SusD-like_2		Starch-binding associating with outer membrane	Coggill P	pcc	JCSG structure (Target 390167)	Family	SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	20.20	20.20	20.20	20.20	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.59	0.70	-6.10	5	655	2012-10-11 20:01:03	2010-02-16 10:56:58	2	5	160	4	277	1675	449	427.60	19	89.34	CHANGED	MKKpILlIVLu.....alClSCuNLEEMNINPspPTpTHPpLLLTslphssF+..pGToGlYAQKhllQsDGEsuDQYYKWsRGSFGuYsTLR........NVpKMsEEAERI..NsPs...................YhALuKFFRuYYFYcLTLsFGDIPYSQALKGETEp.YoPsYDuQEDVFcuILpEL+EAD-ILushsolIuG.......DIIYNGNsspWRKLINSFRLKVLlTLSN+S..GElshsSEFcuItTNSPLM-S.sDNGQLVaLDQQsNRYPpFNuuu.WSGhYMDuTFIQRM+ER+DPRLFIYSTQTsKuKs-GKsIsDFSuYEGGDPAAPYG-uh.KsucGDlS.lNDRa+pDPlsEPhhLhGYAEpQhILAEAAVRGW.IuGsAcsaYEcGV+uSFcFYEsaucDYutYLu.NAVApYLpEPLVD..................FopASSTEEKIERIIMQKYLsoFaQhsW-GFYDaLRTGYP-FRRPoGosIP..........+RWhYPQSEYssNosNVSoAIo+QFGuGNDcIspssWWtK	......................................................................................................................................................................h........h.h...h....s......s....s...p...p...h....t..-....l...N....p..s....P..s.....t......s...p.......p.......s.....s.........s.....t.......h.......l.......h..s.......t.......h...........h........p.......h.......h..t...................s.......................t.............h....h...........h.....t...............h.............h......t...........................s..........t.......................t......p...h.......h......t.................t......t.........s....t.........h......s......h...........h....t....t..h.t.................................s.h.....p...h.....h...p....t....s.....p..p..h........t.t..........................................................................h...h...u...l...u...pl.h..p.......uah...hthhsDhaGD.l.P.Y...o..........-..........A.....h.....p.........u........t........t.........................h..p.....P.....paD..s.Q...c.s......l.Y.....t....s.....l.........hp.......p.Lc.p..A........s....h.....l........s.....s.....s......s.....s..............h.....s..u.....................Dh.l.a.....s.....G......s.........h....s..........p......W....h+huso..L+l.Rh.h....h......+...l.s.....phs.......s.t....h.s....h..t..t.h.........h...t..t.....l....h.......s.....s.....t...s...h........h...p.....s......s.-........s.......h...................h...........h..............s...t........t.....s.....s....................s........h........h........t...............t.........t.......................h...............s....s..........h.......h...h............s..........p..h...h..h......s..............h...h...........p........t............h............p..............D.P...R.l..................h........h.........h.........t..............................................................................t..........................................t......................t.......h.................t.......................................................................s.........................................................................................................................................................................................s...h..................h........h..hshuEhtFlhAEu..h..h..+..u..h......h...s....s......s.......A...pph..Y...........p...p....ul.p.u....u...h....p........h..........s........h...................s....s....t..................................h.....h.......s......................................t...................................................................................................................t...t....t..l..p..p.Ih.h.Q.+alu.ha.....p..s..h.-sa.phRR.........o.....G............h......P..........t........h.......................s..................s...............t......hs...............................hRh...Y..P....t..p....p..h..N........th.....t................................................................................................................................................................................................................................................................	0	119	251	277
+12607	PF12772	GHBP		Growth hormone receptor binding	Coggill P	pcc	Pfam-B_7 (release 24.0)	Family	Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme) [1,2]. Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone [3]. The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage [4].	21.30	21.30	21.30	21.40	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.00	18	1202	2010-02-16 14:01:20	2010-02-16 14:01:20	2	6	789	0	38	1084	0	236.70	57	83.11	CHANGED	KGKL-ElNoILuup.....csYKPphYpDDsWVEFIElD.lD..DssEK..spGSDTpRLL......Spc.p.pcut.sh.GhKDDDSGRsSCY-PDl.-sDh................hL.ttp.sLLshctcstpp..ssspcus.....................sl.tst.cSsp.slps..Qhos..pohsNhDFYAQVSDlTPAGuVVLSPGQps+st.pspsst.............................cpE.hpp.hQh.h..s.ssuYhsEusA+phss.sP...pscst..shcPphsppc.a.ss....sssutsstoshh....uPsup..hPVsDYTsVp.VcS.puLlLNsss.....P......sscp.h	..............................................thap-DsWVEFIELDID....D..sDEK..TEGSDTDRLL......SsD.H.pKSl.sILGAKDDDSGRTSCY-PDI.L.-TDFpsuDhsDu..op.ht.ppL.KtEsDLLCLDpKN.ps....shsts..t...s.......s.csKPpsLl.utsESsp..Q...spT...hSNP...sSLA...N...IDFYAQVSDITPAGuVVLSPGQK.KAG....huQss.h.............................p.E..hss.sQtNa...hssAYFCEuDAKKCIshsP...+hEsps.phcPSFsQEDhYITTESL.TToA.hstss-h....sPsuE..hPVPDYT.olHhVQSPpGLlLNAsu.................sp.h.................................	0	1	5	14
+12608	PF12773	DZR		Double zinc ribbon	Bateman A	agb	Pfam-B_12 (Release 24.0)	Family	This family consists of a pair of zinc ribbon domains.	26.30	26.30	26.30	26.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.35	0.72	-4.14	109	1392	2012-10-03 10:42:43	2010-02-16 17:13:36	2	114	823	0	495	1601	122	52.60	32	16.02	CHANGED	CspCtpt........ssss..upaCtpCGstLt..............................tt....CspCst....s.ssssspFCspCG	............................................CspCGt.t.......................sss.....ucFCspCG.stls............................................................................tt...hCs..pCup...........hs.ssspFCspCG.....................................................	0	174	347	430
+12609	PF12774	AAA_6		Hydrolytic ATP binding site of dynein motor region D1	Coggill P	pcc	Pfam-B_14 (release 24.0)	Family	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D1 unit of the motor and contains the hydrolytic ATP binding site [1]. 	21.30	21.30	21.30	21.40	21.10	20.80	hmmbuild  --amino -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.79	0.70	-4.82	3	2434	2012-10-05 12:31:09	2010-02-17 10:48:36	2	274	341	14	1635	2341	119	209.40	54	6.46	CHANGED	YSYEYLGNTPRLVITPLTDRCYITLTQSLHLlMSGAPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVVAVQVKCVQDAIRDKKctFNFLGEEISLIPSVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDP	.......................................................YuaEYL.G.s.s.s.R..LVITP..LT............D...R........C.Yl.....T..LspA....L...p...h...p.h................GG..u..P......tGPA.G.TG...........KTET.sKDLu+uLGh.s.............lVFN........C...S.-........thD......apu.................hG+hFp.G..L.uQ...s.....G..........AWuCFDEFN.RIplc.VLSV.......lA...p...Q..l.h............s......I........p..........p........A..........l............p........p.............p.............t....................p..................p.............a............................F........................G..............p..............p...............l.....p..L...s.....s...s...s.u...lF....I.T.M....N.P.................G....Y.................A..G.......R........o...E....L.......P-.......NL................K..s............LF.R..slAMhV......PDh.t.lIs.ElhLhSpG.F..h....p..u.c...LupK...hhsh.a.pLs.p..EpLS..p..............Qt....HYDaGhRA.lK.oVLhsAGshKR.......................................................................	0	696	866	1339
+12610	PF12775	AAA_7		P-loop containing dynein motor region D3	Coggill P	pcc	Pfam-B_14 (release 24.0)	Family	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D3 and is an ATP binding site [1].	20.90	20.90	20.90	21.50	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.83	0.70	-5.32	3	2098	2012-10-05 12:31:09	2010-02-17 10:54:55	2	245	278	14	1513	2001	100	255.70	31	7.07	CHANGED	FELDPElPLQAsLVHToETIRVRYFMDLLMERuRPVMLVGNAGTGKSVLVGDKLuSLssDuYLVpNVPFNYYTTSAMLQuVLEKPLEKKAGRNYGPPGTKKLVYFIDDMNMPEVDsYGTVQPHTLIRQHMDY+HWYDRpKLTLKEIHNCQYVSCMNPTAGSFTINSRLQRHFCVFALSFPGQDALSTIYNoILTQHLAhtSVSsALQKlSPsLVuAALALHQKIAsTFLPTAIKFHYVFNLRDLSNIFQGLLFSosElLKoPlDLlRLWLHE	.............................................................................................................t.l.l......V....PTh-TsR.h.p.a..llp.hh.........l.p.........p......p..c...Pl.lllGss.Go.GK.o......s.hl.........p....s...h.L.....p............p...l...........s...............p.....................p.......p......h.............h..................s....h.......t....l..s..........F...Su....t....T..o........u......t...........h..Q.......c.........h....l....-...s......h...l.......-...K......+................p...t............t...............s...........a..G..P......s....t...........u...........K.....+..h...l.l.Fl.DDlNMP.............t....h-p.YG...........sQ.........s.l.p.llRQhh-.h..s..s..a...Y......D...p.....p...c....h...s.......h..hp.l.h..........c......l...p....h.l.u.u..M...............s....P..s.......u.....G........R.....p...s................l.ss...........R...h....h..R+Fs.lhsls...hP..s..p..p..s.lp..pIa...u..s....l..........h..........p.......t....a.......h.......p.........................t..........a...............s..................p.....................l..p....p..h...s..p.....t...l...l....p.u.s.........l..p.l..ap..p..s...t...p..p..hL..P.Tss..K..HY....lFNL...RDlo+....l...hp.......................G.l..h.h....s............p.....p..h.........h....p...s................p.....ll.+LWhHE...............................................................................................	0	634	799	1238
+12611	PF12776	Myb_DNA-bind_3		Myb/SANT-like DNA-binding domain	Bateman A	agb	Pfam-B_16 (Release 24.0)	Domain	This presumed domain appears to be related to other Myb/SANT like DNA binding domains. In particular Pfam:PF10545 seems most related.  This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  --amino -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.32	0.72	-3.36	73	836	2012-10-04 14:01:12	2010-02-17 10:57:23	2	29	65	0	554	860	0	91.40	20	25.51	CHANGED	pWs..sphp+hhl-lhh-phptGsp.......tssasppuWpp.lhppapp....psttpas+pQL+s+...hcpL+cpaphhpplhppss.............huWDsppptlsAs.cchWcph	................................Ws.st.pphhlchh.h.c.phptGpp.......ssshpppuapp.lhp....phpp.......phsh.p.h......s.p.pQlps+.......hcp.h+cpaph.hppLh..p..p.su.........huWDstp.....p.h.l.sAs..c..c.h.Wpp...............................	0	85	356	454
+12612	PF12777	MT		Microtubule-binding stalk of dynein motor	Coggill P	pcc	Pfam-B_14 (release 24.0)	Domain	the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component [1].	24.00	23.30	24.00	23.70	23.90	23.20	hmmbuild  --amino -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.04	0.70	-5.70	3	2476	2010-02-17 11:31:39	2010-02-17 11:31:39	2	258	489	19	1602	2329	102	305.10	29	9.65	CHANGED	ERLENGLhKLQSTAuQVDDLKAKLAuQEVELKQKNEDADKLIQVVGVETEKVSKEKAIAD-EEpKVAVINcEVocKQKDCEEDLAKAEPALLAAQEALNTLNKNNLTELKSFGSPPsAVlNVoAAVMVLhAPsGKIPKDRSWKAAKVsMuKVDuFLDSLINFDKENIHENCLKAIKPYLsDPEF-PEFI+oKShAAAGLCSWVINIVRFYEVYCDVEPKRQALpKANAELsAAQEKLAtIKAKIAELNANLAcLTApFEKATADKLKCQQEAEATuRTIoLANRLVGGLASENVRWAEAVpNFKpQE+TLCGDVLLITAFVSYlGaFTKKYRs-LhERhWlPYL	.........................................................................................................................t..hpsG.LpKLtpsttp...Vt..thptpL..t.......p.....L.t....tp.t.....p.s.p.t.h...h.t...l.....t.......h...p...p..t..t...................s..p......p..p....c..t.........s..t.......t...p.....t............t......h...t............t.t....t...h...............t..t...h.......p.......p.......p.......s....p.......t.......-L.t.pA....Ps..L..p.t..A...tA............Lp...s...l..p..t.........t.sl..sp.l+uhtp.......PP..t.h.V...t.......hl..h..p.u..V..............h........l.l..............h...............t............................................................................................p..........................s............W.......t..s..u..+.....t....h.........h......s.....c....................p..............F...L....p.s.L...h...s......a....D...K......-....s...I..s...p...p....h..h...c..t.....l..p..t...........a......l..p...p..s..-....F.s....s....c............h...l...p..ps..S...t..Astu.Ls....pWVhA...h...t.Yt.c......V.h.+.....V.......t....P....K.+..p...p.......L....t...p...s...p.......tp....L.......pt....stp.p...L.p..ph.ptp.Lpp.l.pp...pltt.Lps...pa.c..p.t..hs...c..K....p..pl...pp...........p.............h.c........h.s........p............p..+......lpp..App...LlsuLuu..E+.........R.........W...................pp....s....s...p....ph.pt.ph..ppL.sGDsLl.......uuu..hluYhGsFstp.aRpphhpt......hhh................................................................	0	659	838	1298
+12613	PF12778	PXPV		PXPV repeat (3 copies)	Bateman A	agb	Pfam-B_15 (Release 24.0)	Repeat	This short repeat is found in multiple copies in a variety of Burkholderia proteins. The function of this region is unknown.	20.20	15.50	20.20	15.60	20.10	15.40	hmmbuild  --amino -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.40	0.72	-4.25	7	141	2010-02-17 11:33:22	2010-02-17 11:33:22	2	4	87	0	42	110	3	22.60	66	23.66	CHANGED	Ghs...APVhs..tPAPVhl.....APtPslV	...........GsP....APVYV..tPAPVYVAP.tPslV.	0	3	14	32
+12614	PF12779	YXWGXW		YXWGXW repeat (2 copies)	Bateman A	agb	Pfam-B_15 (Release 24.0)	Repeat	This short repeat contains the motif YXWXXGXW where X can be any amino acid.  It is generally found in 2-5 copies in short secreted bacterial proteins. Its function is as yet unknown.	18.00	5.00	18.10	5.00	17.90	4.90	hmmbuild  --amino -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.18	0.72	-7.38	0.72	-3.97	88	527	2010-02-17 11:41:07	2010-02-17 11:41:07	2	11	179	0	276	526	23	23.20	37	20.84	CHANGED	shhYlapsGhWah.....u.sa.sGsWhh	...........sYlWssGaWth.........taha..hsGhW......................	3	66	118	207
+12615	PF12780	AAA_8		P-loop containing dynein motor region D4	Coggill P	pcc	Pfam-B_14 (release 24.0)	Domain	The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor [1].	22.90	22.50	23.10	22.60	22.80	22.40	hmmbuild  --amino -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.65	0.70	-5.42	3	2160	2012-10-05 12:31:09	2010-02-17 12:48:52	2	240	286	14	1532	2037	96	247.80	35	7.05	CHANGED	YNEVNAVMNLVLFEDAMpHVCRINRILESPRGNALLVGVGGSGKQSLoRLAAYISSLDVFQITLRKGYGIPDLKlDLAolClKAGVKNlsTVFLMTDAQVADE+FLVLINDLLASGEIPDLFuDDEVENIISuVRNEVKShGLsDTRENCWKFFIDRlRRQLKVlLCFSPVGosLRVRSRKFPAVVNCTAIDWFHEWPQ-ALVSVShRFL-ETEGIcs-VKpSIScFMAYVHTSVNEoS+lYLoNERRYNYTTPKSFLEQIKLYQSLL	...................................................h..sLV.lFp-AlpH.................ls.RIsRllc.p.P.p..G.ps.L.LlG.V.GG.SG+pSL..oR.LA.u.....a.hs..s.h.p..lF..QIp.....l.........s...+..s..Y.s.hs-....a....+...-D..L+plh.tp.....u...............G...h.....c....s...p.t.h.....sFLhsD...spl.............h.c....E.u..FLE..l.Ns..l....L.so.....G..............E........lP.s............LF...s...t.DE....h.p.p.l........h............s..............t........h.....+....s.......t..s........p...................p....t..................s.....h...........s.....o.....t..........p......s.......l..a......p.aF.....l.p.+...........l+.p..NL.....H....l...V.Ls..h..S..P.....lG..c....s...h.R.s.R....h.+..........pFPu.........Ll..N..ss.sIDW..Fp..p..WPp..-ALh..p...V.................u......p.................p.................a.................L....................p....................p.................h..............p...................h...................h..................p...........................p.................h.....................c....................p..........t......l......s.....p...........h...hsh.....h..........H.t.sl.t...ph.s.t....p..........a.h......t..p......p..R.hsa.sTPpsaLchlp.hatth............................................................................................................................................................	0	634	798	1248
+12616	PF12781	AAA_9		ATP-binding dynein motor region D5	Coggill P	pcc	Pfam-B_14 (release 24.0)	Domain	The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution.  This particular family is the D5 ATP-binding region of the motor, but has lost its P-loop [1].	22.20	22.20	22.20	22.30	22.10	21.90	hmmbuild  --amino -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.61	0.70	-5.50	3	2170	2012-10-05 12:31:09	2010-02-17 13:30:02	2	225	287	14	1548	2035	88	214.80	38	6.23	CHANGED	MLTDDADVAsWNNEGLPSDRMSTENATILuNCERWPLMVDPQLQGIKWIKNKYG-DLRVIRIGQKGYLDlIEQAISuGDTVLIENlEESIDPVLDPLLGRNTIKKGRYIKIGDKEVEYNPKFRLILHTKLANPHYKPEMQAQsTLINFTVTRDGLEDQLLAAVVApERPDLEQLKSDLTKQQN-FKIlLKELEDSLLSRLSSASGNFLGDTALVENLETTK+TAAEIE	.............................................................................................................pltpWp....p..GLPs.DphSh.-N..ul........I...l.......p...p.......u.......p............R.......a....P...L.h...ID.PQ...sQ.u..hc.W.I......K.......s................h.........................p.........s.....................p...................L......p........l...h.p.....h......s..p...p.............s...a...h..c.....p....LEpulphGpslLlEs...l..t.E...p..l....DP.sL......pPl.L..t.....+...p.....h....h.....+.....p.....G...................p.......h.........l................+..l....G...D..p..p..l-as.s.s.F+la..loT..K...L....s..N..P...c.Y.....P...E..l.p....s.....+...s.ollNFs.lT......................pGLE..............-QLLuhV..l.tp.E.+P....-L....E..c.p.+sp.....Llh..p.t.....s..................p.K.h...pL+pLE-plL.ptLs....su...............p..G...s...lL......-..D.p....pLl.psLppoKtput-l......................................................	0	635	802	1257
+12617	PF12782	Innate_immun		Invertebrate innate immunity transcript family	Coggill P	pcc	Pfam-B_9 (release 24.0)	Family	The immune response of the purple sea urchin appears to be more complex than previously believed in that it uses immune-related gene families homologous to vertebrate Toll-like and NOD/NALP-like receptor families as well as C-type lectins and a rudimentary complement system. In addition, the species also produces this unusual family of mRNAs, also known as 185/333, which is strongly upregulated in response to pathogen challenge [1].	26.90	26.90	26.90	31.50	21.60	26.80	hmmbuild  --amino -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.36	0.70	-5.20	9	746	2010-02-17 14:14:11	2010-02-17 14:14:11	2	4	2	0	6	908	0	162.80	58	101.52	CHANGED	MEVKVTLIVAIVAALAISAHAQRDFNERRGpENGRERGQGtFGGRPGGMQMGGPRQDGGPMGGRRFDGPsSGAPQ.........................MDGRRQNGGPMGGRRFDGPcFGGSRPDGAGGRPFFGQGGRRGDGEEETDAAQQIGDGLGGsGQFDG.GRtHHGHRQG.PQDpsEEQPFGQRN.SSEEDGRPHPHHHt......+HHpHH...........................................+RNHTEGHQGHNETGDHPHRHHNKTtDtDQDRPMFEhRPFphN...PFGRKPFG-RPFsRRNGTEEGSPRRDGpp+PaGNRGRWGENESEEKE+PTTESlTTSSPsEVVclAhN-	..........................................................u.RQDGGPMGGtRFDGPt.GAPpM-GRRQsGGPMGGRRFDGPtFG................................................................................................................NpTEGHQGHNETGDp.............DQD+.h.-.RPFhhN....FGRKPFGs+.F...................................................................................	0	6	6	6
+12618	PF12783	Sec7_N		Guanine nucleotide exchange factor in Golgi transport N-terminal	Coggill P	pcc	Pfam-B_13 (release 24.0)	Domain	The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF [2].   	25.40	25.40	25.70	25.40	25.30	25.20	hmmbuild  --amino -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.06	0.71	-4.82	70	1211	2010-02-17 14:38:16	2010-02-17 14:38:16	2	22	295	0	824	1186	8	143.70	24	9.89	CHANGED	hshhtpDAhhlFcsLCpLs...p..sppp..shh....tthpschhuLcLlcslLpspts.l..Ftp...............chlp.sl+phLs.sLl+sssS.sh.hslhphshcIhhhLl.pph+stLKhElElhlshlhh...lL.........-.pst....shp..pKhlsLchhpplsp-Pphlh-lYlNYDC-.s..ppNlh	...................................................................................................h..shh.lFcs.LspL......................s...........t...tt...........................................t.................hs+hhuLpLlps.hLps...tss..h..ht..................................phht.hl......+p.lsh....tLhp........hs...........s...s..........................slh......t.h.shplhh.hLl..pp..h............+s.hL+..h........ph.E.............lahp.lhh.ll..............................................pspp.......sht..........p+.h.sl.p.........hlpp.......lh.t....p.s.....p.hlhphahsYDsc.t..ttslh...................................................	0	286	456	677
+12619	PF12784	PDDEXK_2		PD-(D/E)XK nuclease family transposase	Bateman A	agb	Pfam-B_5 (Release 24.0)	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily [1]. These proteins are transposase proteins.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  --amino -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.27	0.70	-5.19	73	2282	2012-10-11 20:44:46	2010-02-17 14:49:08	2	7	653	0	358	1886	49	177.50	20	76.61	CHANGED	spsDauFK+lFGsc.t.NcclLlsFLNslLp..tpppIpclc.llss.......c..t-hts-Ktull....Dlhspss....sGppllIElQhppppsFhcRsLYYhu+shsp...Ql.............p.pG...pt.Yp............pLppllsIsIls.Fshhts.........p....ch+sshplh-ppspp..hhh.........cclphhalElsKFpppppcppsp........h-cWlhalcstsphppt.h.h.....psshhccshpthcphshscc-ht..sY-p+.chhh....Dppsslcpu	......................................................hhp.hh.t.........p.thh.h.t..hlpshLt................t...tlp...lp....h...s...............................p........t.s........+..shh..............Dlhsp.p........sGp..h.lEh.Qh.p........p......p.....t.............h..h........p.Rhh....aYhsphhsp...pl...............................p...pG.......t...Yp..........................pl..t..shhI..l...hs...h.hh.t..................t.............thhp...h...h......p.......p....p.t.........h..............p...t..hh..lph..h.................................hh..hh.......................................h..h...t.h.....s..................................h..............................................................................................................................................	0	126	250	271
+12620	PF12785	VESA1_N		Variant erythrocyte surface antigen-1	Coggill P	pcc	Pfam-B_22 (release 24.0)	Family	This family represents the N-terminal of the variant erythrocyte surface antigen 1, versions a and b, of Babesia. Babesia bovis is a tick-borne, intra-erythrocytic, protozoal parasite of cattle that shares many lifestyle parallels with the most virulent of the human malarial parasites, Plasmodium falciparum. Babesia uses antigenic variation to establish consistent infections of long duration. The two variants of VESA1, a and b, are expressed from different but closely related genes, and variation is achieved through the involvement of a segmental gene conversion mechanism and low-frequency epigenetic in situ switching of transcriptional activity from the VESA1 gene-pair to a possible other gene pair.	21.40	21.40	33.10	21.40	19.60	20.60	hmmbuild  --amino -o /dev/null HMM SEED	462	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.95	0.70	-5.52	42	227	2010-02-18 13:21:03	2010-02-18 13:21:03	2	2	1	0	141	227	0	260.00	32	38.40	CHANGED	AAVTDLLQSVpLEYH.............GYQG-sK.......tssssKGAsccpVs..c+LNGLFSLVQGLGGTAVVRTYIDQLAQVLSALVGWS+I-KC......................tssspCpssststp........................................................HGppss....CcYLcDVctss.sCscCGCMKWsVsp...spscGppLGRtCTRCpsSGsstt......CpCusuust...Cou.spc.CKCAhsGKC....CKCC.....Cpspss.t........Cptpt............uChpppp..............-....sYhSAYsp...................h.ttttht..hpshWssLhp.s...............ssSp..+RHpCARILLGSVCLIWSGlTYMYWTGKYtpoSPRWNNHILDGSGLDDGTLSQWLQALGFP+-MLNNsGPtNRLDuVIWDGhpsKLaLGFscsushss...s.upDsssNThRsPsGMNYAGaIHTscRsuFsss.AsVFppsssss........ho-psppKpGALaKLYILSCAYFTGL....QKK....................puss+TPKTIREILYWLSALPYSpAY.clLcHuKc+L	........................................................................................................................................................................................................................................................................................................................................................................................................C.tptsss.....sts...cpCpC...s.h..s.G..t.............................................................................................................................................h..hAp.hLGslsLIaSslo.h......s..........s..t....hWpt................................tahtshGas...hp.........................................................................................................................................................................................................................................	0	141	141	141
+12621	PF12786	GBV-C_env		GB virus C genotype envelope	Coggill P	pcc	Pfam-B_19 (release 24.0)	Family	This the envelope protein from the ssRNA GB virus genotype C.	20.40	20.40	20.40	20.80	19.70	19.70	hmmbuild  --amino -o /dev/null HMM SEED	413	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.86	0.70	-12.75	0.70	-6.01	6	568	2010-02-18 13:22:19	2010-02-18 13:22:19	2	10	6	0	0	453	0	191.40	59	45.18	CHANGED	Rls.lPNLTCslcCDhcash.uhsl.....Dh.WshchlhcLPh+LW+GlsuhssLhllVlhhLlLEQRLVMsFLLLhssGpApss..............hapuCpCth.GuRsP.Pshpsh.RGNuTllC-CPFGpMhWhPsLCuGLsW+DGspc...GsspsLPhsCPcpVhGoloVhChWGSAaWhWRhG...shVcLacpLP.tSALCTFauhspucpsaPt.VssLospGsPCASCVVDpRPspCGsCVRDCWEpsGs...sFccCGlGsRlTccLpAVlVcGGsESploTPhGERP+YhuQHGsGsaauAVpthuhshTVoclGGYWHAltCPs.-assGsLPchIPGhPVNACls..scsu+shuuW.APGGaYAPlFT+CNWPpssGVcVCsGFAaDFPGc+sGFIHV+GuhQQlhuGshtssPpWLL	..................................................................................................................................................................uluWGDPIs....tGQsp..........aGusSVss.......................................................................................................................................................................................................................................................................	0	0	0	0
+12622	PF12787	EcsC		EcsC protein family	Bateman A	agb	Jackhmmer:Q186V8_CLOD6	Family	Proteins in this family are related to EcsC from B. subtilis. This protein is found in an operon with EcsA and EcsB which are components of an ABC transport system [1]. The function of this protein is unknown.	27.00	27.00	27.20	27.30	26.70	26.80	hmmbuild  --amino -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.46	0.70	-4.98	47	901	2010-02-18 14:38:34	2010-02-18 14:38:34	2	5	716	0	203	677	35	219.90	21	83.19	CHANGED	a.pptlp-lppWcpc...p+csthhp+hs+hs.phl....scllPptlpctlssslc....phsphlhsGupalh................................................shpslpphsLpphDplscchhpthpphAsspGAsTGsGGlhhhhuDhPllLulplKhLa-lAhhYGaDsc-hcERlFILplhQluhS.s.tt+ptlhpplpp..........acttpp....t..splp..s....W+ph.ppYRD.hshtKhh........QhlPslGhlhGAhsNhphlcclu-sAhhhY+hRhl	....................................................................................t.....................................................................................................................................................................................t...h........p....h....p..t..h...h....p...p...h..ht..p..ppthA..sspGus.....oG.......h.......G....................Gl..h...........s......h.s....s....-lP.......s....hl....s....lt....h....+....hlt........plAp.hGaD.l...s.c......cpph.hhLt.l...h.t.h...uht....s.p......tc..p..t.h.hth.h.tt...........................................htt.t.t.................t..t..hp...h.s.......................hcpltpp....h...t...s.l...s....h....p...phh.........................phlP.l.l.Gus.lGAssNhhhhpplschApttathRhl...............................................................................	0	69	145	168
+12623	PF12788	YmaF		YmaF family	Bateman A	agb	Jackhmmer:Q181M3	Family	This family of proteins contain 6 HXH motifs and is named after the B. subtilis YmaF protein.\	 It seems likely that these are involved in metal binding. The function of this protein is unknown.	27.00	27.00	27.30	27.40	21.80	26.90	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.83	0.72	-10.59	0.72	-3.84	10	130	2010-02-18 16:13:56	2010-02-18 16:13:56	2	1	90	0	33	113	0	90.10	43	77.47	CHANGED	+hQoHsHEFtuSTchAE-s-.-cHNHRhAGVTGpAI.h.G.sSHVHKI.pspTDFF.DHFH-lClTTGPAIhl.usGKHIHLVpGpTTlNDGHpH-ahFTTLI	.........................pHsHEa.uSTphsp.t..........p.c.HNHRhuGVoupsI.h....G..ssHVHpl.p.s.pTDF.h.sHaHhIs.shTGPAIsl.uss+HlHhlsGhT..ohsD..G..HpHcahhsT.l.....................	0	15	24	28
+12624	PF12789	PTR		Phage tail repeat like	Bateman A	agb	Jackhmmer:Q181M3	Repeat	This family largely contains proteins from the eukaryote Trichomonas vaginalis.  These proteins contain multiple HXH repeats. Some proteins in this family are annotated as having phage tail repeats. The function of this family is unknown.	27.00	7.00	27.00	7.00	26.90	6.90	hmmbuild  --amino -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.66	0.72	-4.13	16	1947	2010-02-18 16:37:43	2010-02-18 16:37:43	2	34	108	0	1744	1922	24	47.00	41	23.61	CHANGED	chScKsHTHoIusITsLQETLspKuDhsHTHTIANITNLQ..ETL..pp..DVGHTHTIusITN	....................................HtHsI...usIssLp-oLsc.Ku.........Dh..s...........H..T.H.s....................................................t..............................	0	1732	1740	1742
+12625	PF12790	T6SS-SciN		Type VI secretion lipoprotein	Coggill P	pcc	Pfam-B_27 (release 24.0)	Family	One of the virulence mechanisms of E coli is the production of toxins which it produces from dedicated machineries called secretion systems. Seven secretion systems have been described, which assemble from 3 to upto more than 20 subunits. These secretion systems derive from or have co-evolved with bacterial organelles such as ABC transporters (type I), type IV pili (type 2), flagella (type 3), or conjugative machines (type IV). The type VI secretion system (T6SS) is present in most pathogens that have contact with animals, plants, or humans. SciN is a lipoprotein tethered to the outer membrane and expressed in the periplasm of E coli and is essential for T6S-dependent secretion of the Hcp-like SciD protein and for biofilm formation.	21.60	21.60	21.80	21.70	20.60	19.30	hmmbuild  --amino -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.49	0.71	-4.57	149	1326	2010-02-18 16:39:03	2010-02-18 16:39:03	2	3	848	1	228	812	20	148.70	26	83.77	CHANGED	slhLuGCu........................s..h.tpssplslslpAssslNsst...pGpssPlhl+lYpLcssssFpsu-a.sL..hps...sppsLus-ll.spc-hh.ltPGpptp.ls................hshspsspalGllAtapchs..pup.W+hlhslsttt.........................pht.....lplplsspsl	.............................hlLsGCu.......................................................tsu....ppspplslslhupsslNsss...puc...ssPlhlplapLpssstFpsADa...sl..tss.........tpssLssshl.s.ppchh.LhPGp.t.pp.ls................hpls.p.p.spalGVl.Atapc.s...tsp.W+hlhpltsts.........................chtlhlplpppt..........................................	1	31	88	154
+12626	PF12791	RsgI_N		Anti-sigma factor N-terminus	Borovok I, Coggill P	pcc	Borovok I	Family	The heat shock genes in B. subtilis can be classified into several groups according to their regulation [1], and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in the bacterial phylum Firmicutes [1]. Regulation of sigma factor I is carried out by RsgI from the same operon, and this N-terminal cytoplasmic portion of RsgI ('upstream' of the single transmembrane helix) has been shown to interact directly with Sigma-I [2].	21.40	21.40	21.50	21.40	21.00	21.10	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.58	0.72	-4.30	52	279	2010-02-18 16:43:53	2010-02-18 16:43:53	2	6	205	0	71	235	0	56.00	24	13.15	CHANGED	lclcccpsllhTscGcFlcl+ppss..hplGpcI.hpppshhphtpthh..hhhhshshh	.......h-lcccpsllLTscGcFlp.lKp+sc...hhlGcEIphsppchht..pptth...hhhh.h...sh................	0	35	63	67
+12627	PF12792	CSS-motif		CSS motif domain associated with EAL 	Coggill P	pcc	Pfam-B_29 (release	Domain	This family with its characteristic highly conserved CSS sequence motif is found N-terminal to the EAL, Pfam:PF00563, domain in many cyclic diguanylate phosphodiesterases.	21.60	21.60	21.70	21.60	21.40	20.80	hmmbuild  --amino -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.17	0.70	-4.99	138	2685	2010-02-19 09:08:36	2010-02-19 09:08:36	2	3	774	0	211	1380	30	205.10	21	40.43	CHANGED	pphppphpshuppslpph-p......llsps.ppshsph...shssps..Csps.hhtLpphshtt.al+slsll.cssplhCSShh.G.h.shshs...s.h......h......shplhhhtssshhsspshl..hht.ts....hsssushsslssthh....hhthh..phsshhlt.......h.spthlttts....t.h.ttssh..........hhhphpSsc.....ashslh.......stsststhhphhhphhhhhl	..................................p..hppchsshuspshcph-p......lhtph.ptstpth...t.htsps...Cs.A.thpLpphutth.hlcslshl...cssphhCSSlh...s...t..shs...h....s.h.ssh..........hp.......ssplhl.hs.sssh..h.sp..hl..hhh..pss..shhssusa........stl.p.shhht...l.hsh.s.phssssls..................l.spshlptts......shhhp.sth...............htpspssc.....hslslh.......lhssstth.thaat.hhh..h..............................................................................	0	15	45	130
+12628	PF12793	SgrR_N		Sugar transport-related sRNA regulator N-term	Coggill P	pcc	Pfam-B_33 (release 24.0)	Family	Small, non-coding RNA molecules play important regulatory roles in a variety of physiological processes in bacteria. SgrR_N is the N-terminus of a family of proteins which regulate the transcription of these sRNAs, in particular SgrS. SgrR_N contains a helix-turn-helix motif characteristic of winged-helix DNA-binding transcriptional regulators. SgrS is a small RNA required for recovery from glucose-phosphate stress in bacteria [1]. In examining the regulation of sgrR expression it was found that SgrR negatively auto-regulates its own transcription in the presence and absence of stress, and thus SgrR coordinates the response to glucose-phosphate stress by binding specifically to sgrS promoter DNA [2].	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.38	0.71	-4.08	49	1737	2012-10-04 14:01:12	2010-02-19 13:52:54	2	2	824	0	137	981	7	113.50	39	20.26	CHANGED	+lhppapRLapths.....spstpsTLsElA-hLaCScRHsRsLLppMpptGWLsWpspsGRG+RSpLthhhsspplptphAcchlcpGchcpAlplls..cpttltplLppphGtphppu	...................h.pQa.RLaQtss........GcsppsTlsELA-hLhCScRHhRoLLpphQ-tGWLpWpupsG....RGKRo.pLpFLh.os..sLppphsEchLEps+hppllpLlt...s......tuplpphL.sahGtpapps......................................................	0	24	45	93
+12629	PF12794	MscS_TM		Mechanosensitive ion channel inner membrane domain 1	Coggill P	pcc	Pfam-B_24 (release 24.0)	Domain	The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this domain is one of the inner membrane domains.	23.40	23.40	23.90	23.50	22.70	23.30	hmmbuild  --amino -o /dev/null HMM SEED	340	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.04	0.70	-5.83	72	1372	2010-02-19 14:00:30	2010-02-19 14:00:30	2	5	800	0	153	777	52	322.70	42	30.04	CHANGED	hpshlhhlhhlLlhhhll....hh+pphpptLpphspclGplppDshhhT.pulhhollhuLPhslhhhhsGhhlt.hs.hsts..tslusulhthuhh.hhlathhhphhpspGlhhtHFphsppplpphp.+hhphhhhhllsllhhhshs.....pthssphhpsslGplshllshhhlshhhh...slhctshs.hts......t...phlppllhhhlhhsPlhlhlhshhGYaaTAhtLht+L.tSlhlhhhhhllapllhRhhhlppRRLAacRApt+Rpp..hh......pEt...t.ssc..........hp.l-.Esslcl-pIspQSL+Ll+hlLhlhhlsslhhlWu-llss.huaL-s..IsL.W	...........................h....LshhshLllsGh.h....aptpahptalp+hAutVGplp.pDp.hhT.+slhhsllhAhPlsllhhslGhhLh.ph...hslushlhshspths.h.hhVhhlCh.phhcsNGlhltHFGhPcppsu+hh.R.hlh.hhhllPLhhh.lhh.............-..s..+.h.sssL.GphshllhhhhlAllsh...slp+tuh..h.s..............phhph..lhhshlhhhPlshhlhoAsGYhhTu.tLhuRh.poV.hlhhlh.llYpslhRhh.lttRR..l.....AacRAhtRRtp..hl......cE.........usp..................................uh.ss-.EsplsL-tIstQoLRlsp.llhhlhhl.hhslWS-lhos.FuaL-s..IoLW..............................	0	21	56	106
+12630	PF12795	MscS_porin		Mechanosensitive ion channel porin domain	Coggill P	pcc	Pfam-B_24 (release 24.0)	Domain	The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.	31.40	30.50	31.40	32.60	31.30	30.40	hmmbuild  --amino -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.73	0.70	-5.05	69	1277	2010-02-19 15:07:52	2010-02-19 15:07:52	2	3	738	0	127	672	19	235.70	40	21.69	CHANGED	ppLcplpp..ppssspppthlpsLppsLshLschcctcpcspphpptlsshPpphcplpppLpshpss.......sstshhsshohspLEpplsptpspLtphpcpLpphpsplhplpsp.pphpsphspsppplppIpppLpsh.sss....sslppuppshLpsE.shlpsphp.hchphhussshQ-Lh..phpp-h.hptchppL-pplQtLpstlNppRhppuEpslccspp.tpp..p.sptsshlppp	....................ppL-phpt.....hpst.pt.l.psLpssLssL-chcpstEcspQhpphlsphPchhpphpA.pLssL.cs...........EsRpl.sshShcpLppclhQs.spL.s....tppphtp.psplhplpsp.ppl.pt.hsAppQLppIcp....RLsu....h....ssGp.........ssLp.uQphhhQu-pAhLpAplDp.chu........ussshQ-Lh..............phpp-h.sptpSppL-t.LQhLpptlNSpR.p.uE+shppsp..sEs..phphs.hlhpp................	0	14	42	86
+12631	PF12796	Ank_2		Ankyrin repeats (3 copies)	Bateman A	agb	Jackhmmer:Q183I8_CLOD6	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.45	0.72	-3.64	620	110723	2012-10-02 12:10:21	2010-02-22 09:13:01	2	6024	2889	200	69620	109701	6937	89.50	23	36.39	CHANGED	Lh.hAsp...p..s..p.........h..p.h..........l.c....hL.....................l...p....ps.......s.....shs.....................ps...............................................sL.h......h.....A................s....................t..t...up.....h...........................................................................c..hlch.........L.lp...............................................................ts...s.s..h.............stp.......................tupTs............................Lhh.............A..........st..................psp...h...c..hl.........c.h.Ll.p.p...............s..s.sh.s....hps	................................................................................................................................................................................................................................................................................................................................................................................................h.t.........h....................................................................h.....t.......t..................s...phs..........................................spT................................................................................................sL.p.........h..........A............................u............................................t..p....G...p.....h..................................................................................................................................................................................................................................c....h....l.c.h..........L...l.p...................................................................................................................................................................................................p.G.....A....s...l...........................stps...................................ppGt.T..s........................................................................................L.p.h................................A............................s.p................................................p.u..p.......h....c.......l.....l.................c..h...Ll..p.t..........s..s.p.......................................................................................................................................................................................................................................	0	33547	42383	56433
+12632	PF12797	Fer4_2		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q184V9	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  --amino -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.65	0.73	-7.77	0.73	-3.72	423	1399	2012-10-03 08:56:42	2010-02-22 11:31:53	2	39	752	0	175	6075	978	26.70	70	12.06	CHANGED	hthhhs....ts..p...C...hs...C..tt..C...ht..sC........Ps	...........Y.GFFID.......SS..RCTG...CKTCEL..AC........KDh+sLss.............	0	59	106	145
+12633	PF12798	Fer4_3		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q184V9	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  --amino -o /dev/null HMM SEED	15	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-6.94	0.74	-7.15	0.74	-2.97	447	625	2012-10-03 08:56:42	2010-02-22 12:42:34	2	99	466	0	231	9841	2305	17.30	47	7.78	CHANGED	C..ht..C.............stCh.psCP..t...ss	....................C..hp...C......................................suCVsAC..s..........	0	69	134	183
+12634	PF12799	LRR_4		Leucine Rich repeats (2 copies)	Bateman A	agb	Jackhmmer:Q187Q2	Family	Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions.  Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.52	0.72	-4.27	569	21961	2012-10-02 21:32:02	2010-02-22 13:07:11	2	3572	1441	188	8913	43842	1514	44.60	29	11.83	CHANGED	p..sLppLp......Ls.p...N......p....l...p...s.....l..s.....s...........l..p....s........L...s....p....LppL.....s...l...s.........p.....N.p..l....p.......s..........l......s...s...l...p....p	.................................pLptLs...............Ls.s....N..........p....l......s.....s.......l..s........................s..............l..u.....p.........................L....s.......s....LppL...s...L...s......................s.........N.p..l.........s.........s..........l.....s.........................................................	0	2700	5198	7123
+12635	PF12800	Fer4_4		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q184V9	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	24.00	10.00	24.00	10.00	23.90	9.90	hmmbuild  --amino -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.47	0.74	-7.83	0.74	-3.15	187	4289	2012-10-03 08:56:43	2010-02-22 13:24:58	2	168	1372	4	663	24462	7195	20.30	39	10.05	CHANGED	t...sp......C.....h.....p......Cs...t.....Ch.ps..Cs.................hp	....................tpC..........l.......G..................C+.........s.........CphA..C...sh....................	0	214	424	548
+12636	PF12801	Fer4_5		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q189G9	Domain	Superfamily includes proteins containing  domains which bind to iron-sulfur clusters. Members  include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	22.00	0.00	22.10	4.40	21.90	-999999.99	hmmbuild  --amino -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.76	0.72	-4.17	217	6537	2012-10-03 08:56:43	2010-02-22 14:38:41	2	113	2159	0	1700	6678	530	48.00	21	19.61	CHANGED	hshhhl.lhhh.hllhhshl.......hGR.haCuWlCPhGslp-hhtp.........hhppph..thp	.......................h...hhh.lhhh..slhlhshh........htR..saCualCPhG.slhslhs.................................................	0	631	1249	1513
+12637	PF12802	MarR_2		MarR family	Bateman A	agb	Jackhmmer:Q17ZV2	Family	The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR.  A large number of compounds induce transcription of the mar operon.  This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.62	0.72	-4.30	266	11347	2012-10-04 14:01:12	2010-02-22 15:12:01	2	65	2832	42	3627	27482	2684	60.70	22	32.41	CHANGED	h.Gl..s..hsphtlLhh.ltptss....................h..ohsclsc..thtlsc.sslsphlppLtp..pGll.........ppp..ts.t.DpRt	........................................................tl.s....tph.pl.L....hh...L...t...ppss......................................................h.....shs-Luc......ph.tl......sp.sslophlpcLpp...pGLl.........p+p......ss.p..DtR................................................................	0	1112	2404	3087
+12638	PF12803	G-7-MTase		mRNA (guanine-7-)methyltransferase (G-7-MTase)	Coggill P	pcc	Pfam-B_40	Domain	The Sendai virus RNA-dependent RNA polymerase complex, which consists of L and P proteins, participates in the synthesis of viral mRNAs that possess a methylated cap structure. The N-terminal of the L protein acts as the RNA-dependent RNA polymerase part of the molecule, family Paramyx_RNA_pol, Pfam:PF00946. This domain is the C-terminal part of the L protein and it catalyses cap methylation through its mRNA (guanine-7-)methyltransferase (G-7-MTase) activity [1].	25.00	25.00	31.00	29.90	21.10	21.00	hmmbuild  --amino -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.86	0.70	-5.29	29	388	2012-10-10 17:06:42	2010-02-22 16:14:03	2	3	87	0	1	397	0	319.70	39	14.47	CHANGED	phuaplYYhRlpGcpphh-YlhshLpRhstssLsslusslSHP+laRRhhssGllpPhpuP.Lso.sahthsh-hlhtuhcpaLs.lhsG..hchphllspsspshls-RhtslhAR+LslLssLassspphPpI+GLsshEKCtlLTcaLpptshts......hsshphslps.plssasssLhYlpRpslppIRhc...s.....s.hhltphhcshsh.ptshtttps..........tsshppssph..hp.....l.spspthpph.hsssttsshp................pHhhRhlGlsSTShYKAlplsphlpphh..pGspLaLuEGSGAhhohhchhlsss	.........shuYQlYYLRlpGhpsIl.Yhsshh+pMsshllsslusTlSHPhIapRhhssGllp.stu.pLAspDahchuscllhoCscphlssLhsG..sca-lLhsss.-DsLs-+h.plluRhhClhssLauss+chPpIRGLospEKCulLT-aLhu-Ahps......tsppspsIhsPpIhsaPusLaYhpR+SLshIRtRp........csshls.hh.sp.sllc.p.spshhuphpt.....shs+pssuhl.ths....Lssss.phcthh..psps.psh.............t..lpahFRsIGhsSSSWYKAsclhol.chpts..pcGsuLYLuEGSGAhMolhEhhlstp..	0	1	1	1
+12639	PF12804	NTP_transf_3		MobA-like NTP transferase domain	Bateman A	agb	Jackhmmer:Q188E0	Domain	This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.11	0.71	-4.16	571	9345	2012-10-03 05:28:31	2010-02-22 16:22:27	2	87	4058	75	2565	24779	11854	170.00	18	55.35	CHANGED	ullLAGG......p...u......p.....Rh...........G.......s...........s.........Ks..l........l.h.......s.G.....p...........s...llp+sl.ptl............psh.......h..s.............................plhls....s..st....p.............p..h.h.....t..................................h............t..th........s.....ht....h.....lt-........t......s..t.........GPh....uu...ltsul.....................................p....t....s........p.....s...sh.............ll..lhssD.hPh...lsssh.lppLhpth...............t......p....s...........s..s.......h..ss..st.t.p.........s..p..h.......................................................hp.P.l......l..h.....stp...h...h...........st.lp....p.h........t..s....s.........p..u......h.......+p...ll.p...............p.h.....t....ps	................................................................sllL.A.u...G.......p......u.......s.....RM....................................t.........s.......s.................Ks..L........hpl........sG.....c......................................s...hl.p+..sl.....cs.h.................p.p.h.....t...s..s....................................clh..ll......s......sp......c.................p....h.t....t.......................................................h..h...............t..t......................s.......lp.....h...........l.h.s.................s..........p.....h.................G.s..h........t..u....l...h...s....u..h............................................................pt......h............t.s.pt........................h.l....l...h....s......u.D....h.......P..h.............l.....s.....s....p.....h.......lp..p.L...hp.th........................................t..........t..s........h....h..h.......h...............................................................................................................................................................................................................hhthhh......................................................................................................................................................................................................................................................................	0	846	1696	2182
+12640	PF12805	FUSC-like		FUSC-like inner membrane protein yccS	Coggill P	pcc	Pfam-B_45 (release 24.0)	Domain	This family has similarities to the fusaric acid resistance protein family. The proteins are lodged in the inner membrane.	20.60	20.60	20.60	20.90	20.50	20.50	hmmbuild  --amino -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.66	0.70	-5.48	75	1796	2012-10-02 19:04:43	2010-02-22 17:07:20	2	5	1161	0	248	1140	37	272.10	36	38.74	CHANGED	sLhhoLlsFhluohslplhhsa..shhFslslhhsoFshshLGAlGpRYuoIuFuoLllAlYThlshs.........ts.thatpP..llllsGAlWYslhollhphlaPppPlQcsLApsappLusYLcsKusLF...cPs.ppppspphphtLAtpNspllsslNps+psLhpRht.us+tp.ssp..+hLphYahAQDIHERsoSSHh.pYppLpcthp.pSDlLaRhp+llphQupuCpplApulhhpp.Yp......asschptuhpplpsuLph.tpp...psttpt.hhtsLptLhpNLps....l-ppL	......................................LIlshhsFhluShss...pLL.h.s.h..shhhslsL.oh..T.hs.hhlluslGt.+a.Aplu.huuL.l.lA...IaThhssu.........h.....h.apps....llllhGulWYslhshhhahlas...pPlp-sLupsYcpLAc.YLEs.Kuph.a.....s..pc.....s-....sptslhsLs.h.tp...t.pl.hst.lsQs+tp..lhhp....us+sppss+..RhL+hahhA.D.laE+hS....uSph.p.Ypplp.ch.hc..+S-lh.hh..hpphhph.ut.shppL....ucsIL.tp.Yp......+tsphc...hshp.ch.uuLE+htpp.....ssst.hhhpluhlhpsL+s.......h.....................................................................................................................................	0	38	107	183
+12641	PF12806	Acyl-CoA_dh_C		Acetyl-CoA dehydrogenase C-terminal like	Coggill P	pcc	Pfma-B_46 (release 24.0)	Domain	this domain would appear to be the very C-terminal region of many bacterial acetyl-CoA dehydrogenases.	26.00	26.00	26.00	26.00	24.90	25.90	hmmbuild  --amino -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.56	0.71	-4.28	470	2011	2010-02-22 18:15:35	2010-02-22 18:15:35	2	6	866	0	708	1823	1503	128.00	25	21.59	CHANGED	thhsclpshhppttt.....t....th.t.shsptLtpu.hpplppssthlhtpst.ss..........s...pts..hAuussY..LchhGhlshuahah+hAhsA.tth......................tt...................................t....ts......Fa.puKltsA+FahpplLPcssuhhstlps..Gsss.lhshst	...........................h.hhtplpphsppttt.........st..th..t.thtp.Ltpu.hpplpp...hTthlht...psh..ss............s...ppssAuussYLphhGhlshuahat+.hAtsAtppl...............ss...............................t.....ts...ts.....FYpuKlssA+FahpplLPcssuhhstlpu..ussslhshs..............	0	183	408	579
+12642	PF12807	eIF3_p135		Translation initiation factor eIF3 subunit 135	Wood V, Coggill P	pcc	Pfam-B_2213	Family	Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation [1].	21.30	21.30	21.40	21.50	21.20	20.80	hmmbuild  --amino -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.30	0.71	-4.32	65	500	2010-02-22 18:22:24	2010-02-22 18:22:24	2	76	258	0	376	485	1	166.80	22	13.01	CHANGED	tsppssPhDGpoLophLHpRGINhRYLGc.......lup......htp....................pLttlppLslpEhlsRuhKHlhpphlp.....................................sl.ss.................sthuusluHhLNCLLGst.ss............................pspsphcpph..................................................t.....spss.satplTs...............ppLhppIppplpp+acasLp...............schhs........p.lp+hpLLRslshKhGlQlhs+-YsFs	.....................................h......PhDG.toLsch...hHp+GINhRY.LGclhph.......htp....................................................................................plpt.l......pplslpEhlsRuhKHlhpshlp....................................................................................................................................................................................................sh.....................hs..ss.luc.hLNslLus..ss......................................................p................................................................................................................h..hs........................ptl.h.p..lp..p.hh.hapapl................tp.hp.........t.hppht.llRths.+hGlplh.+.ca.h....................................................................................................................................................................................................................................	0	144	232	330
+12643	PF12808	Mto2_bdg	Mto1_bdg;	Micro-tubular organiser Mto1 C-term Mto2-binding region	Wood V, Coggill P, Eberhardt R	pcc	Pfam-B_28820 (release 24.0)	Domain	The C-terminal region of the micro-tubular organiser protein 1 (mto1) is the binding domain for attachment to Mto2p.The full-length Mto1 protein is required for microtubule nucleation from non-spindle pole body MTOCs in fission yeast [1]. The interaction of Mto2p with this region of Mto1 is critical for anchoring the cytokinetic actin ring to the medial region of the cell and for proper coordination of mitosis with cytokinesis [2].	21.40	21.40	21.50	21.40	21.00	21.30	hmmbuild  --amino -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.08	0.72	-8.55	0.72	-3.86	9	126	2010-02-22 18:30:33	2010-02-22 18:30:33	2	5	97	0	91	132	0	50.50	39	5.17	CHANGED	+WlpRLcELEppLKAER.EARhhD+oGA+cRLp-hptENccLpApLp+p+.pp	........+hl.RLcELpp+L+uER.E.....tRhhDpsuAcpRlpclcsENcpL+ucLph.p.t........	0	13	35	67
+12644	PF12809	Metallothi_Euk2		Eukaryotic metallothionein	Wood V, Coggill P	pcc	Wood V	Family	This is a family of eukaryotic metallothioneins.	80.20	80.00	80.20	80.00	78.60	78.40	hmmbuild  --amino -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.27	0.72	-3.59	2	16	2012-10-05 18:33:37	2010-02-23 09:22:44	2	1	13	0	2	9	0	75.50	58	72.34	CHANGED	sl+.pDCEstCCpcus.pCtSpCh.psStGphCpsph.hGp.pspsChcphpC.........ohs..pCpK.u+pphtKp	ClRNQDCEoGCC+cAPspCESHCsEKGSEGSLCQspsFFGQYRsCPChcNLTChY.KstKW.oIsaGpCQKlu+ppLtKp...	0	2	2	2
+12645	PF12810	Gly_rich		Glycine rich protein	Bateman A	agb	Jackhmmer:Q183Y9	Family	This family of proteins is greatly expanded in Trichomonas vaginalis. The proteins are composed of several glycine rich motifs interspersed through the sequence. Although many proteins have been annotated by similarity in the family these annotations given the biased composition of the sequences these are unlikely to be functionally relevant.	24.50	24.50	24.60	24.80	24.20	24.40	hmmbuild  --amino -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.36	0.70	-4.79	103	677	2010-02-23 09:42:22	2010-02-23 09:42:22	2	34	107	0	572	663	155	230.70	22	43.92	CHANGED	sCTs.YplpLs.sGhY+hElaGAuGGs.t.............................hpp......ss....h.G......GtGGYssGhlplppppphYlhlGupG............p.s.....tp............h..h...GGasGGGpust..........................t...hu.uuGGG..uTcl+hh...........................ssLtsRl....lVAGGG.GG.u.ss.......st..........t.sp.............................................................................G......GsGG..Gltu....tssh....tt....sp.........ss.s...........uu.sp.puuG..u.............hp...p...........s..t.......sGshshus......ss.....sp.................u.......GGGGGaaGGhuu.............p.....t.s........uu............G.GGGSSal...hsp..su..hh................s..tsslps.......sshhapssthhpss...................tp................pp.................GsGhhpITlLs.h..t.hs..s..phh	................................................................................Y.hph..hG.AtGG...................................................t....uhGs.hh.uhh......l.t.p..t....ha.hhlGtpG.......................p...................................tsh..sG.s.s...s........................................u.uuGGG..uT.l.hh.....................psh..phl....lVA...u..GG..GG.s.s........t.............sp.................................................................................u.....GtGG..uhtutssh.......tt.................st........................susp....h.tsu..tu........................h..p...........t.t.....pGshuhuu.........ss....ss..................................uGGGuGahGGtuu.............................t..ts.....ss...........G..uGGSSal...ts...h.......................................................................................................................................................................................................................................................	0	505	515	542
+12646	PF12811	BaxI_1		Bax inhibitor 1 like 	Coggill P	pcc	manual	Family	The Bax-inhibitor-1 region of the receptor molecules is conserved from bacteria to humans.	22.90	22.30	23.10	23.10	22.80	22.20	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.90	0.70	-5.24	8	694	2012-10-01 20:22:31	2010-02-23 10:16:08	2	3	645	0	171	575	640	247.90	32	92.43	CHANGED	M...RcoSNPVFRSL.......PK.ppG.GYA........pFGou.Auuhus..QphstpsYtst.....ppssssRshTIDDVVsKTGITLuVLshsAVVSYFLVssNssLuhPhshlGulGGLslVLlATFGRKtDNPulVLsYAuhEGLFlGulSalhuNlhsuGusu..hIsQAlLGThGVFF..GMLVVYKTGAIRVTPKFTRMlluuLaGVlsLhLGNllLAhF.sGss....LpsGGsLAIhFSLlCIGlAAFSFLlDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYlEILRLLSYhpN-	.................................................................................................................................................................................................................................................ttt.ss..p..p.s....MTlssllsK.T.u.l..h..L..t.l.l..h.s.s...u...s...h.....u....a.....h......h...h.....h......s......p.............s...h....s...h.........h.......h....l.....l...G.u.....l.s.u.hl....l.u.h.lss...F..t..p...ph.sPsh..s..l....h..YAhhEGlhLGulSh.ha.p.......t.......h.su........llhpAl..Lu..Thushh.sh.Lh.lY+.sthI+VTs+FpphlhuuhhGl.hlhhLs.s.hlLshF....s...ss...................hlts.....u...G...s.....l.G.Ilh....Sll..s.lslAAhsLl.lDFDh.h-pulct......tAPcp.......h.tWhsAhGLhVTLVWLYlEILRLLShhp..p........................................	0	46	106	140
+12647	PF12812	PDZ_1		PDZ-like domain	Wood V, Coggill P	pcc	Pfam-B_17100 (release 24.0)	Domain	PDZ domains are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates. this is a family of PDZ-like domains from bacteria, plants and fungi.	28.00	28.00	28.00	28.20	27.90	27.90	hmmbuild  --amino -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.45	0.72	-4.09	34	382	2012-10-02 11:12:46	2010-02-23 10:45:31	2	15	206	0	258	391	21	76.80	30	13.96	CHANGED	sITPsRaVpVuGAoFHcLSYQ.ARpaslsl+..GVaVucuuGShph......ss...tspuallpplsspsTPsLDsFlcVh+plPDp	..............lpss+hlphsGAsh+clsaptsRph..s..h..sht...shhs.u.c.u.s.GShth.......ph...lssshlIppVsspsTssL-sFlclh+pIPDp.......	0	56	147	227
+12648	PF12813	XPG_I_2		XPG domain containing	Wood V, Coggill P	pcc	Pfam-B_10579 (release 24.0)	Domain	This family is largely of fungal proteins and is related to the XP-G protein family.	29.20	29.10	29.20	29.10	29.10	29.00	hmmbuild  --amino -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.69	0.70	-4.88	26	211	2012-10-01 19:52:02	2010-02-23 11:52:00	2	8	149	0	162	230	5	227.40	18	35.47	CHANGED	tssFhVsslhEsL+sp.p...................................aushs.llsGEADsaCAhhA.+phGs.sVLTsDSDLLlHDL.G.pGullFhsol-hss...................................................t.hplpAhphpssslsc+Lul....sl.hlAa.........El.ppcsctshspllcpu+t..spssspppspYhsFlcpY........ts...........ss.thptLDs+loElhhph....................tcptsplYLshLl-stuRpsAWt..pupphR.lAYulhshpt.......hspptssltEhhRp...upchsspplsl	...............................................................................................h.s.hhh.shhpsLpph......................................ss.hhhs...u.EADt.hA....slA..pph.s............C.......sVLo..sDSDahla...cl......psualslsslp.hcs..............................................................................................hl.psphap.sphsp.p.hsh..............Ls..hh..Ah................-h.t..s..h..tp.h.....ph.h.th..stt........t......t...tph.thhp.h......................................................................................................................................................................................................................................................................................................................................................................................	0	65	86	127
+12649	PF12814	Mcp5_PH		Meiotic cell cortex C-terminal pleckstrin homology	Wood V, Coggill P	pcc	Pfam-B_1220 (release 24.0)	Domain	The PH domain of these largely fungal proteins is necessary for the cortical localisation of the protein during meiosis, since the overall function of the protein is to anchor dynein at the cell cortex during the horsetail phase. During prophase I of fission yeast, horsetail nuclear movement occurs, and this starts when all the telomeres become bundled at the spindle pole body - SPB. Subsequent to this, the nucleus undergoes a dynamic oscillation, resulting in elongated nuclear morphology. Horsetail nuclear movement is thought to be predominantly due to the pulling of astral microtubules that link the SPB to cortical microtubule-attachment sites at the opposite end of the cell; the pulling force is believed to be provided by cytoplasmic dynein and dynactin.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.76	0.71	-4.20	26	320	2012-10-04 00:02:25	2010-02-23 11:54:51	2	30	183	0	235	344	1	121.30	30	9.25	CHANGED	sllsAIsQTMlGEahaKYsR+p..p..h..............................tpsRHcRahWlpPYppsLhWSsppPtsussptspspp.lhIpuVtsVcDsNshPpGh.......ap+SIlIhTssRslKlTAsoppRHplWhsALpaLhpp	.............................................t.hhpAIspshlG-ahaKYsR+t...t..............................ts+HcRaFW.ls..P..a..pps..LhW..Ssp.pPp.pss....t......hpsp...................p....ltIpu.Vps.V..pD...s...s......s..hP.uh................ap....c..Sll..ll.os.p....R..sl+hTssotp++psWhsuLpaLh....................................	0	67	124	195
+12650	PF12815	CTD		Spt5 C-terminal nonapeptide repeat binding Spt4	Wood V, Coggill P	pcc	Pfam-B_197031 (release 23.0)	Domain	The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe [1]. The repeat has a characteristic TPA motif.	25.40	24.80	25.60	25.10	25.00	24.40	hmmbuild  --amino -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.74	0.71	-12.09	0.71	-3.70	33	296	2012-10-02 12:52:19	2010-02-23 14:16:34	2	28	170	1	213	294	3	130.10	32	17.37	CHANGED	uu+TPAasu..........sGu+TPAW...tsGupTssh.h................GuRTPsass....Gu+TPh..................htsGu+TPAauusss...........upTPuast......................................................ssshhuusoPush......sss.TPuu..tusTPu.....................s.uusoP	...............................................................upTPhass...........GuRTPta.....GSpTPh...s...............................GuRTPsat........GopTPh...............................tsGSRTPAauus.s...................spTPu.hstt....................................................................s.....s...ss.....................................................................ss.........................................................................................	0	76	113	178
+12653	PF12816	Vps8		Golgi CORVET complex core vacuolar protein 8	Wood V, Coggill P	pcc	Pfam-B_90 (release 24.0)	Domain	Vps8 is one of the Golgi complex components necessary for vacuolar sorting [1]. Eukaryotic cells contain a highly dynamic endo-membrane system, in which individual organelles keep their identity despite continuous vesicle generation and fusion. Vesicles that bud from a donor membrane are targeted and delivered to each individual organelle, where they release their cargo after fusion with the acceptor membrane. Vps8 is the core component of the endosomal tethering complex CORVET (class C core vacuole/endosome tethering).  Vps8 co-operates with Vps21-GTP to mediate endosomal clustering in a reaction that is dependent on Vps3. Vps8 is the only CORVET subunit that is enriched on late endosomes, suggesting that it is a marker for the maturation of late endosomes. Late endosomes form intralumenal vesicles, and the resulting multivesicular bodies fuse with the vacuole to release their cargoes [2].	19.90	19.90	20.90	23.50	18.90	17.20	hmmbuild  --amino -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.19	0.71	-5.06	42	312	2010-02-23 17:00:45	2010-02-23 17:00:45	2	13	243	0	230	320	2	182.20	31	13.50	CHANGED	pslFL-sLEsaIlpGplpslPPtlhKsLlpaassppphpplEclIspLDssoLDlDpsspLCccasLYDAlIYlaNpslsDYloPLh-Llphltp.tp..............hsts...........ssuhKlasYLuhlLoG+tYPoGcth.spp..cshpuKpplaphLFSupshshs.ssst............cssFPYLphlLcFDspsFLshLspuF	............................................................................slFL-sLEPaIlpsplp.s.l.sP..tlh+sLlsaa.t.spt.........h...h.........pplEphIh+hDhsoLDl.sQ..llpl.....CpcapLYD..AhIYlaNcu.hsD...YloPl...cLlp..llts.hptt................t.hstt........................................s.u.KlhsYlS..hsLs.GRsYPh.Gc.h..sp.p...............h..s.psKppl....apaLhptp.shphs.t................................c..aPal+hLLcFDsppFLssLs.sF.........................................................................	0	86	132	195
+12655	PF12818	Tegument_dsDNA		dsDNA viral tegument protein	Coggill P	pcc	Pfam-B_48 (release 24.0)	Family	This is a family of tegument proteins from double-stranded DNA herpesvirus and related viral species.	20.70	20.70	20.70	20.70	20.50	20.10	hmmbuild  --amino -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.51	0.70	-5.53	11	214	2010-02-24 16:15:47	2010-02-24 16:15:47	2	2	24	0	0	95	0	223.90	74	46.53	CHANGED	lppuhhHlHSslpshup.QLpshlFpsoLhPtspspuushGhY.sTssu.sushstshpcplttsspspucsLspsGVPVluGFl+sl....pptuthstsslhpsShLsosspstLshsR.thGQhlVsLGsFpPssGsDssPahYp-SshshN+lhpsLcLFtphhsssClSuhtRshG.soslcHLhuLl.tsGhpLalSpLPp-lhstLtussssp.st..lcphVpsaFLNshss.lFLllspcs......spsps.psL-hLppAuclsGCshhlLGcTsspsGl	................................................IHGAYTHVHSSVQRGIR.GLGNLLFHSTLFPGGQTQGALTGLY.ATEPA.LGPRAHSRFRRIFAKGVQ.....QAEMLQGAGVPTLGGFLKTV......RTIATTP...G.NALAVCS.....IS....TTTSKE....CIS..LRRMI.P...QQ.T.VVC.LGR..FEPTD.GPDTYPNLYRDSSDNAVRILETLKLVQRLA..KG..P..IF..SGL..NRSHDPAPVVRHLQALAP.R.TGLELFVSKLPDEV+s+LsAcPuAsssu..VcusVu-HFLNVYCSlVFsVVu-oG....ulPuDhGcTPLElLQRAARLCuCQlsVLGRToEpPGI.....	0	0	0	0
+12656	PF12819	Malectin_like		Carbohydrate-binding protein of the ER	Coggill P	pcc	Pfam-B_41 (release 24.0)	Domain	Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases.	20.80	20.80	20.80	20.80	20.70	20.70	hmmbuild  --amino -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.84	0.70	-5.36	155	1073	2012-10-01 23:47:32	2010-02-24 17:09:37	2	67	112	0	617	1235	5	284.20	22	44.21	CHANGED	IDCGhsssps..a.-..s.slsasoDs.sahs..sGt...hth....t.t.t.s..h.p.htslR.FP...tsp..+.sCYsl.sh...ttt.+YLlRspFhYGNhp.........s..t.ph....ss.F-LhlGsshWssVph................hhtE.llhss.....t..splslCLlssu....ss..PFISuLElRsL..psshY.................h.ps.sts..LphhtRhsh.uss.................................lRYssDs..aDRhW........s..............ssthpphss.....s......hs..t.st.t..tsPptVhpTAhss..ssss................lphsa......sh.ssss..p............ahlhhHFuElpp...ps.........RpFslhlNst.........shps.hhhstsh..hpshhhph.tst.....hhh.sLttsssS....sl.sPllNAhElapl	............................................................................lsCG................sh.ahsDt..thht......ss.........s.pl.......................h.shR..Fs.............t....p..sY.sh.s....t....pahl.RhhF..h.......sshs............t.............s.a..l.hh.sh....s.hh...h........................hhhE.hh.ss...............s.lplsh.hsps........ss.sFlsslE..lhsh...ss.p.ha.............................ts..Lphh....hRhsh..Gspt................................lphssDs......hsRh..W.........sh...........................ssthtt.hss.............t.p........hp....ststh..hsP..t....V.hpT.......Ahsh...ssst..................hp.hsa........ph...ssss.h.p.............ahlhhaFsElpt...t.................tR.FslhlNsphh......p......sht.s....h..h.t.s...s.h.........ht..hhh.t.h...st..........h.lslt..ss.to........th..ssllNuhElhp......................................................	0	88	348	486
+12657	PF12820	BRCT_assoc		Serine-rich domain associated with BRCT	Coggill P	pcc	Pfam-B_51 (release 24.0)	Domain	This domain is found on BRCA1 proteins.	21.30	21.30	21.80	21.30	20.00	19.40	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.13	0.71	-4.48	83	1101	2010-02-25 13:43:55	2010-02-25 13:43:55	2	15	761	0	20	1126	0	159.50	55	27.54	CHANGED	ADsLstRKEhscQKs..CS-sPR.coQD.lPWITLNSSIQKVNEWFSRSD-hLTS.DsopDttsESNuElAuslEl..Ps-lDGaSuSSEKlDLhAS.-Pcsu..llscSERlpSKPVES.NIEDKIFGKTYRR.KuSLP..NLoHl..TE.sLIlGAh.AsEPQIsQEpPh....TNKLKRKRRT	...........................A-PLpGR+chpKQKssCS-SPR..DoQ-.lsWITLNSSIQKVNEWFSRSD-l.LTS.Dco+DtssE.SNsEsu.sslEl..PspsDGhSuSSEKhDLhAS.-sp.............s.A..LhpcSERspSKPVES...NIEDKIFGKTYRR.KuShP..NLs..+s..TE...sl.llGus......shEPp.lspEp.Ph....TNKLKRKR+h.................................	0	1	2	5
+12658	PF12821	DUF3815		Protein of unknown function (DUF3815)	Bateman A	agb	Jackhmmer:Q183G2	Family	This family of membrane proteins is functionally uncharacterised.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.52	0.71	-4.21	94	3677	2012-10-02 11:53:07	2010-02-25 14:38:39	2	9	2742	0	637	2738	47	132.40	26	47.57	CHANGED	lphlhualAsluFullhsl..P..+..+tlhhsulsGulGWhlYhlh.h.p...hs.hs..h.hh.ushhuulslulhuphhA+hhKsPsslFhlPu.llPLVP......GstsYpshhthl...................p............sp............httu...........hph....................................hlpslhluuAIAlGlhlsshl	...............................h.phlhuhl.u.sluFu..l..lh..N.s..sh...+t..L..hhsull.G.u..lu.a.h.h.h....hlh..h.p...........hs...hs....h....h....h.uoF..h.u.uh.llGh...l..........u....t.........h..h......u..+...h...h..+.........s........P..s....h..l..a..........hl.su..llPh.VP......Gh.huY.p.uh...hshl...............................................p............ts........................hspu...........h.sp............................................................hhpshh..lssAlu...lGlhlsph.h.....................................................................................................	0	196	382	532
+12659	PF12822	DUF3816		Protein of unknown function (DUF3816)	Bateman A, Iyer LM	agb	Jackhmmer:Q188H8	Family	This family of proteins is functionally uncharacterised but are likely to be membrane transporters. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 177 and 208 amino acids in length. A subset of this family  is associated with the TM1506 proteins. In this context, transport through the channel is predicted to be regulated by the TM1506 protein by either regulating redox potential or modification of substrates [1]	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  --amino -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.66	0.71	-4.37	172	3851	2012-10-03 02:46:00	2010-02-25 14:48:37	2	6	1995	2	522	3039	57	168.30	20	85.15	CHANGED	+pl..............shhullsAluhlLh.........hh.hs....l.........p.hshsplssl..lu.....uhhhGPhsGhhluhl...psllphhh...h.................................................s.hh.hh...................hsshlsthhhslsss....hla..tppppptth.............................................................hhuhhluslhhslssslh......shhlh...h.ha...................h...............................................shhthlhhshlshsllcsllssllshhlh	..................................tlshlulhhAlshllt...........hhs.hs.....l...........p..lshsp..lssl...lu...........uhlhG......PhhGhlluhl....psllph.....l....l.....s..sh....................................................s.......................................hhshlsthl.hu.lssu.........hl.a.p..h.h...p..p..p.s....h....................................................................................................................hhu.l.llu..s..l.hh..o.ls.h....ol...l.............shhhh...........h.las................h.....................................................................slhthl..h..s.s.ll.s.hs.llctllsullhhhl.h..............................................................	0	216	361	451
+12660	PF12823	DUF3817		Domain of unknown function (DUF3817)	Mistry J	jm14	Pfam-B_123 (release 24.0)	Domain	This domain is of unknown function.  It is sometimes found adjacent to Pfam:PF07690 and Pfam:PF03176 which are both transporter domains.	27.00	27.00	29.10	28.80	26.10	25.90	hmmbuild  --amino -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.16	0.72	-3.55	149	830	2010-02-25 16:16:58	2010-02-25 16:16:58	2	6	649	0	275	668	179	92.30	31	73.20	CHANGED	sslpt...aRllAhhEulohllLl.luM.slKY...h...........h............shs....h..slpllG........l.........HGhl.FllYllhshtlshch+Wsh.tchlh.shlAullPFuoFhhE.+hlp...+c	........s.slttaRlhAhlpGlshllLl.luM.slKY...h.....................................s..................shs.....t...sVpllG.......h.s..................HGhl.allYllss.h.luh.ch+Wsh.tph...............lh.shlAuslPFsoFhhEphhp+.p............	0	92	210	255
+12661	PF12824	MRP-L20		Mitochondrial ribosomal protein subunit L20	Wood V, Coggill P	pcc	Pfam-B_1364 (release 24.0)	Domain	This family is the essential mitochondrial ribosomal protein subunit L20 of fungi.	30.10	30.10	30.10	30.20	30.00	30.00	hmmbuild  --amino -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.02	0.71	-4.28	34	157	2012-10-04 14:01:12	2010-02-25 16:34:37	2	4	148	0	105	147	0	159.90	28	73.35	CHANGED	hhps+spuohp+s+pphp..lpPs.o...................llaNPPuSuPoshp....TPttFL...PtsDsR+phh.ttt.t.s............................spphPslhptcsp.....+p..YpLos-sIpEI++LRtpDPhpao+tpLA+cFssSshFlshls..pss...p++cthcph.Lpslcs+W.us+RthAR-..DRp+R+Eh.W	................................................................................h....p.pss.tptt.thp..h.Pt..................................hhapPssStsos.h....sPh.hFL...PtsDsRRth..........tt.................................................tphPslhpsppt.................+p....apLssp-lpEh++LRtpDPhpaohppLA++Fss...SthFVthls........psst.....p+pp..cph....hpthpppWs.p+phARc...-RphR+phh......................	0	23	53	87
+12662	PF12825	DUF3818		Domain of unknown function in PX-proteins (DUF3818)	Wood V, Coggill P	pcc	Pfam-B_972 (release 24.0)	Domain	This domain is found on proteins carrying a PX domain. Its function is unknown.	21.70	21.70	22.70	21.80	20.90	21.60	hmmbuild  --amino -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.93	0.70	-5.77	27	228	2010-02-25 17:01:20	2010-02-25 17:01:20	2	11	134	0	189	245	0	268.10	26	34.73	CHANGED	sLtclFpEl+ppsslp-LSP.hpsFsEWs+lplAuTlYphFlusD.NS.Ehasp.....s++lHpLhPYslhtpllRhoNPhulMpshlDLFL......................AQP...FG.u+SLLQphFshhLs--l+shcctlcpLcp.plts.....phhhp+lcpal..ss-.....s....hhstl+c-utp.....pshslllsILpssp......p...stlss.....splpclhpSYhsapshhpp..........................sptppstuhhasplKplhplhh+cRDKchMppLhp-.PthspLlKsllolFY-PLl+la+sAslp.ulpsFppFhsDLIphl-phppt..hhhssshpsVpthhsLls+HpssFacFlHclah+Dst.....lFpslhpWlcpllphL+psh	.......................l.plhtplttptplppLs..hpphh-ahp...l...p...lAuhlaplFlsp-.su.thhtt..........h+clHplhPYthhpphl+hsNPhshhpuhlclhL......................ups....hG..upsLhQ......phhuhhlp-...s...h..pp..hpct.lctl.tt.plts............hhhpplctas..tscp..........pptl+tc.utt.....pshsll..hslLpsp.....t..s.ls..............tthtpl.ps...a.......................................tt.ha..hpphhphhhppRD+t.hhpl...hp........c...s...h.hphh+s.hh.s..hhYpPlh.c.laptusl..slpshttFhsDhIt......h.........lcth...........p................h.....................t........s................ps.........VpshhsLht+HppthapFlHplhhpsst.....latthhtWhpthlthh+p..s......................................	1	59	117	167
+12663	PF12826	HHH_2		Helix-hairpin-helix motif	Bateman A	agb	Jackhmmer:DISA_CLOD6	Motif	The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.82	0.72	-4.09	72	5697	2012-10-03 02:11:09	2010-02-25 17:13:14	2	57	4306	6	1394	5279	3189	61.40	32	9.52	CHANGED	clh..hh...LGIRaVGppsA+hLApcFt.ol-sLtpAohE-Lhplc-IGshlApSlhpFFps.psppll	........................+hlhu..LG.I+pVGtpsActL.A.p.....c.Fs..o.......l.......-....s............l..........t....p..........A............o..........h............E..............-..........L...t.....p.....l...s...slGthlA.pslhsaFtptt..t....................	0	461	920	1195
+12664	PF12827	Peroxin-22		Peroxisomal biogenesis protein family	Wood V, Coggill P	pcc	Pfam-B_15020 (release 24.0)	Family	Peroxin-22 is a integral peroxisomal membrane protein family. The N-terminus is in the matrix and the C-terminus is in the cytosol. The N-terminus carries a 25-amino acid peroxisome membrane-targeting signal. It interacts with the ubiquitin-conjugating peripheral peroxisomal membrane enzyme Pex4p anchoring it at the peroxisomal membrane. Both Pex proteins are involved at the same stage of peroxisome biogenesis.	21.70	21.70	21.70	63.60	21.40	20.80	hmmbuild  --amino -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.56	0.71	-4.39	17	42	2010-02-25 17:17:23	2010-02-25 17:17:23	2	1	41	3	28	39	0	120.70	32	66.90	CHANGED	ptsptp.pp+hsscSlslslSpolhssph..ls.hhhsscshlhllsPsls.t...............phphppp.tthtssaKllpCsshp...................GhapllKpL+schLL...................................lssD-ls.s.......lspD...............ls+Flppllsl	........p..tppspcp+hspKShsIl.lScSl.u....Plph..hss--lVhllPPsho.ssh..............t.thtps.pppts.paKlIpCcohp...................GhauslKpLptpphl...................................lsocDhssu.......lPcD...............ls+Fl+plls.......	0	5	15	25
+12665	PF12828	PXB		PX-associated	Wood V, Coggill P	pcc	Pfam-B_972 (release24,0)	Domain	This domain is associated with the PX domain.	20.90	20.90	21.00	21.50	20.70	20.40	hmmbuild  --amino -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.67	0.71	-4.56	28	179	2010-02-25 17:31:20	2010-02-25 17:31:20	2	11	129	0	143	195	1	138.40	37	14.82	CHANGED	M......................tLossppHaLK+.LlchpLtpElpthspP.....ssLppaGhPFps.t.......s.ppppsp...............................hPlLpahhppFlh..oFPhl..........ptstppcFWps+lQsFlEphsptslSsS.D+p....ploKR+plspKhpshlhLhhsos	..................................s......p.LTspQpHYLK+pLlptQlp.tElppLss.P.......sALppaGhPFpss.......sph..ss.pt....t.p...........................................................................................................................lP.l.L.+alFhcaVh..sFPhL...................ppstpc-.....FWQsKlQs........FlEsFssppl...SsSt...DRt............c..oKR+pLutKhp+lltLhhsS.u...........................................	0	42	84	126
+12666	PF12829	Mhr1		Transcriptional regulation of mitochondrial recombination	Wood V, Coggill P	pcc	Pfam-B_7788 (release 24.0)	Family	This family is involved in the transcriptional regulation of recombination in the mitochondria,	20.50	20.50	20.50	41.20	20.00	18.70	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.78	0.72	-4.16	24	112	2010-02-25 17:49:44	2010-02-25 17:49:44	2	1	111	0	86	104	0	90.70	37	29.53	CHANGED	ausplalF+NlposQVlYSpsPshspppl.pQh.hsshcs+.......sshR+DhW+sMsVlsFs...shphulpsYpsLtchRhhR.pls.tcps.ph++	........aG.plalacNlcosQVlYS.s.tlcpppl.pQhsh....upcsh......PssLR+DhWpPhsslpFs....ssphG....lpsYptLREh+hhR.pls.sc-h.ph...................	0	13	41	71
+12667	PF12830	Nipped-B_C		Sister chromatid cohesion C-terminus	Wood V, Coggill P	pcc	Pfam-B_443 (release 24.0)	Domain	This domain lies towards the C-terminus of nipped-B or sister chromatid cohesion proteins.	26.40	21.50	27.30	21.60	25.70	21.00	hmmbuild  --amino -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.88	0.71	-4.65	57	312	2010-02-26 10:34:20	2010-02-26 10:34:20	2	9	257	0	213	314	3	182.20	28	10.29	CHANGED	hsuulsQ+ahpplLc.hshsppsplphhAlcllphll+pGLlpPhpslPslIALpss.spshlpphAhphhpplppKapuhlpsp...hspGlphuapapppl.tp....h...............................ssshhsplapllp.ss+..psRpcFlpslh+hhp.p..............................t.lphhhalspslAhlsaps.-Eslhllppl.....ptl.l	..........................huoulhQhaLcplLc.hhhpppsplphhAlp...........llthhlp.QGLlHPhp....slPhLIA.....LtTs.spsthpphA.p.hpplccKatuhlct.c...hht.G.lphuaphQpsl.ss.pssh.t..................................................................ssuhhutLY..sl.l+..ss+..ppRctF...lpslhpha-tp...................................s.splphhha.lu-NLAhhsYps.-EsLhllppl-hh.................................................	0	73	120	180
+12668	PF12831	FAD_oxidored		FAD dependent oxidoreductase	Mistry J	jm14	PfamB_47 (release 24.0)	Family	This family of proteins contains FAD dependent oxidoreductases and related proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.48	0.70	-5.40	240	2577	2012-10-10 17:06:42	2010-02-26 14:20:32	2	89	1337	8	853	18895	7151	241.30	22	42.20	CHANGED	DVlVhGGGsuGlsAAlsAARtGt....pVlLlE..ppshLGGhsouuhs.sshhu...........h..t........................hhsG.lhpEhhpcl..........tt...t.......................t..........................a-Pcshptlhcphl......tc..s.........slplhhpstl............sslt....t.....p...s.......................c..lpulth..................spt.u....thplpAchalDuTs-GDLsshAGssaph.GcEsps...hsps.....ssh........................hh.......phssh..............................................sptht........h.....hph......thssps.tpth..sh..................stsas.tphph..................thhpt.............................hsup..........hsh...................h-hh.........shscuph..psR..cplh......p.hhtslhpal.....t..................Ghtp....splt..................thu.thhlREoRRlhGpaslTppDl.........hs............t.........ppas......D..uluh.usas.lDhH....ss.pth....................tsh..thtsss..........Ys.I........PaRuLlP.ps....hcNLlluG+slSuoHhAhuohRl.ssshshGpAAGsAAA...l...u....lcpst..........s..s.ppl.......s.....hppLpppL	.........................................................................................................................DllVlG.uGsuG..h.sAA.l....s..A..A..c..t....G..t..........cV..l.L.l..E..........c..........p..........s...........h..........l......G.......G......t.....h...s....t....t....h..h............................................................................................................h...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	296	586	747
+12669	PF12832	MFS_1_like		MFS_1 like family	Wood V, Coggill P	pcc	Pfam-B_20770 (release 24.0)	Domain	In fungal members this domain is found at the C-terminus of putative transporter proteins.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.31	0.72	-4.19	39	546	2012-10-03 03:33:39	2010-02-26 14:36:54	2	10	360	0	338	2373	283	74.60	24	14.28	CHANGED	.hhhLushYFhaFuslGslhPYhulahc.p.hGassppIGhlhsllhhoclluPslauhluD+huptthllhhushhsh	......................................h.lpsh.Y.Fh.a.a.u...sh....Gs..h..h....P..a..h....slah.....c.....p...hG.....hs.ss.p......l.....Ghlh....u.l.h..........h.....h.ch....lu....ss.l.aGhluD+.h.t.pt.thllhhuhhh..s...........................	1	135	186	282
+12670	PF12833	HTH_18		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q17ZT7	Domain	\N	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  --amino -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.61	0.72	-3.88	512	57814	2012-10-04 14:01:12	2010-02-26 15:54:55	2	267	4045	19	12899	44029	2241	79.60	26	23.35	CHANGED	lApthshSt+pLp+hFp.phh.G.hostpalpphRlppApphLh..p.............s...s...h..s.l.pc..lAhphGFsshupFschF+chhGhoPsph...+pp	..............................................lApphshStppL.p...+hF+.p.h......G..ho...htpalp.phRlpp....Ap.ph..L...p...................................s....s.......h...s..l..sc..lAhps..G.a.s.s...s.tFs....+tF+.+h..h..G.hoPspaRp..........................	0	4087	7939	10539
+12671	PF12834	Phage_int_SAM_2	Integrase_l_N;	Phage integrase, N-terminal	Coggill P	pcc	Pfam-B_50 (release 24.0)	Domain	This is a family of DNA-binding prophage integrases. It is found largely in Proteobacteria.	21.90	21.90	21.90	22.00	21.80	21.70	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.84	0.72	-3.60	22	357	2012-10-02 14:21:04	2010-02-26 16:41:55	2	6	239	0	81	331	30	87.30	33	31.33	CHANGED	MscLsh-hKpLA.+.p.s.u.GSapThpsRh+hhpphuccL.ttLshplpssppLKs+HlEuhlpphhupsIottTLpNcMutlRhhhppAGRspls	.................................t.Lttphh.tLA.+..p.s.u..GSa.KT..hpDRh+lhpRhsccL...ht.h.sl..p..lpps..pplKs+HIcsYlpphh.s.p.G......luh+TlpN-MuslRslhptsG+ppl..........	0	14	32	61
+12672	PF12835	Integrase_1		Integrase	Coggill P	pcc	Pfam-B_50 (release 24.0)	Domain	This is a family of DNA-binding prophage integrases found in Proteobacteria.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  --amino -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.13	0.71	-4.53	21	412	2012-10-02 14:09:14	2010-02-26 16:45:15	2	7	286	0	101	918	314	159.80	31	55.67	CHANGED	GluuASRs.GTKhAIss.-capplLspsctpD.pGlAsslpLuRhhGLRocEAVQsspSL+TWppuLtp..G-s+lpVVFG...TKGGRPRcTpll..-p-plhpslppAlthupppsG+LIc..+PsL....+sAhcpa+shspc.uGLsG....pauPHSLRYAaAp-AhpaahppG.hSp+EAhAhsSMDLGHGDGRGcYltpVYs	.......................................................................................................hpthhpt..sp....t......p.....c......t......l...A......s....u.....l..p....Lu.+hh...GLRspEu.......lph.......s.........t.......s.h.......t....................................h....p...........spp...p.l...t...l.h.h.G...........TKG..G.Rs....Rps.......lh..........pp..th...h.p.s........l......p...p.....A.......h...........t..........h....s....t........p...p....s.........s.p...L.Is.......c.s.l...................+ps..h..p......h.....a.c..p.t.h.pc.....h....G....l.s.t............t.h..s...s...HuLRauaAQ.c.th....phh..................tt......s..h......s..........................................ht.thtH.................................................................................................	0	14	48	78
+12673	PF12836	HHH_3		Helix-hairpin-helix motif	Bateman A	agb	Jackhmmer:Q182I3	Domain	The HhH domain is a short DNA-binding domain [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.84	0.72	-4.03	335	8248	2012-10-03 02:11:09	2010-02-28 11:38:54	2	52	4067	5	1906	6460	471	64.20	37	14.92	CHANGED	VNtVGV.....-lNTASssLLp.p.l.u.Gl..s.sslAcsIVpaRcp.p..G.sFpsRcpLh.cV.tlGsKsaEQsAGFLR	..........................tstV...sl.NTA.....Ssp......Lp..p.l...s..G..l..u..tphApsIls.YR-c..p..G.sFps..h..c-Lp...cV..stlG.sK.shEphtshlp...................	0	618	1220	1609
+12674	PF12837	Fer4_6		4Fe-4S binding domain	Bateman A	agb	Jackhmmer:Q180F8	Domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich.	25.00	24.00	25.00	24.00	24.90	23.90	hmmbuild  --amino -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.38	0.73	-7.55	0.73	-3.87	236	737	2012-10-03 08:56:43	2010-02-28 11:44:55	2	86	681	0	169	11950	1256	25.10	45	8.00	CHANGED	hsphc.tspC.h.......p...C..tp..C..hts..CP.....t....t.....sl	........hthD.cpKC.s.......p...C.....h-.....ChcV..CP....E.....................	0	70	132	154
+12675	PF12838	Fer4_7		4Fe-4S dicluster domain	Bateman A	agb	Jackhmmer:Q182B4	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.21	0.72	-3.58	464	18155	2012-10-03 08:56:43	2010-03-01 13:25:32	2	690	4323	11	4999	30460	7729	57.40	30	15.10	CHANGED	pC.......h.....s...C......s.....tC..h..ts..C.................................................P.......hp..s.l.p...........h...p................p...............t......................................t..................t...h....................................t...h...p....s...p...p..........C......h.............t................C.........................s.........t...........Chs.........s..CP..p..ss	............................................................pC.l....s...C.....s.....tC..s..ps..C.........................................................................................................................................P............ts...s.....l.p...........................h.p...........................t....................t.................................................................tt....................t...h........................................................p...l....s...........p....p...............C......h.........................t........................C......................................................................G...........t.............Chp............sCPsth..........................................................	0	1801	3427	4346
+12677	PF12840	HTH_20		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q182F8	Domain	This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.71	0.72	-4.17	108	9773	2012-10-04 14:01:12	2010-03-01 16:12:49	2	62	2904	43	3329	15478	1487	61.20	27	39.10	CHANGED	sphh....ps.....Lus.ssRhpllptL.................ttpshossplucth.....s......hstss.lphHL.ctLpc.uGL.lpspcptc	.........................................hhpA.......Luc.PsRh.p.llph..L.........................tpts.hs..s.s.....cl..spth......s...............lspss.lSpHL.phLpc.uGL.lpsc+pG...................	0	1109	2238	2834
+12678	PF12841	YvrJ		YvrJ protein family	Bateman A	agb	Jackhmmer:Q189G4	Family	This family of short proteins are related to B. subtilis YvrJ protein. None of the members of this family have been functionally characterised.	27.00	27.00	28.10	27.80	24.50	25.70	hmmbuild  --amino -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.72	0.72	-4.66	46	323	2010-03-01 17:10:41	2010-03-01 17:10:41	2	2	270	0	80	239	0	37.80	44	70.26	CHANGED	phIuNlGFPIsVulYLLlRlEpKl-pLspuIpcLsptl	.........hIuNlGFPIsVolYLLhRlEsKL-sLhpuIpcLspt........	0	33	65	71
+12679	PF12842	DUF3819		Domain of unknown function (DUF3819)	Mistry J	jm14	Pfam-B_986 (release 24.0)	Domain	This is an uncharacterised domain that is found on the CCR4-Not complex component Not1.  Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [1].	21.50	21.50	25.10	24.60	21.10	19.20	hmmbuild  --amino -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.89	0.71	-4.51	61	378	2010-03-02 15:41:44	2010-03-02 15:41:44	2	10	282	0	261	393	2	143.20	37	6.88	CHANGED	psp.L+pll.hAls+A......l+EllsPVV-RSVsIAshTTcpllpKDFAhEsDEs+l+pAAphMlpsLAuSLAhlTC+EP...L+ts....lpspl.+sl......lp..tssts............h........-phlphlssDNl-LusslIE+sAhE+Alp-I..-ctltsththR.+ppRp	.......................p.L+phlp.Al-RA......lpE..ll.p.PVV-RSlpIAshTTcpllpKDFA......h-sDEs+hRpAAppMs+sLuuuhAhlTC+EP...Lphu....lsspl.+sh....ht.tthtts...........phh.......-pththlssDNl-LuCshIcKsAhEKAh.-l..-ctltsphphR+ptR......................................	0	98	150	222
+12680	PF12843	DUF3820		Protein of unknown function (DUF3820)	Mistry J	jm14	Pfam-B_72 (release 24.0)	Family	This a bacterial family that is functionally uncharacterised.	21.10	21.10	21.20	21.40	21.00	21.00	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.25	0.72	-4.36	77	1116	2010-03-03 15:03:50	2010-03-03 15:03:50	2	5	1053	0	236	562	60	64.00	55	65.46	CHANGED	hspctLlcLsptpMPFGKYpG+hLhDLPEtYLlWFtpcG.FPpGcLGphLtlhhElKlNGLEsLlcPL	............M-pEpLlclAssh.MPFGKY.......KGRhLlDLPE-YLLWFARK..s.FPtGcLGcL.hplsL.IKhpGLppLlpPL..........................	0	53	126	190
+12683	PF12844	HTH_19		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q180H4	Domain	Members of this family contains a DNA-binding helix-turn-helix domain.	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  --amino -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.93	0.72	-3.92	149	14559	2012-10-04 14:01:12	2010-03-03 16:22:39	2	171	3576	20	2358	33000	4379	62.70	22	31.97	CHANGED	Gcpl+chRppp..sl.o...hpplup.......phth.....p.....pstlsphEps....pp.phs.....sptl.......hplsphhsls.hp....phhpthpp	..............................ppl+plR.p.p.p.......sl.o.......ppclAp...............pl.sh............s................pstlS.p..hEpG..............pp..pss............hppl....................hpls.p.hh.s.ls.hs.......hh.....p...........................................................................	0	826	1594	1964
+12684	PF12845	TBD		TBD domain	Bateman A, Masci AM	agb	[1]	Family	The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation [1]. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side [1].	21.40	21.40	21.70	22.40	20.70	21.20	hmmbuild  --amino -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.66	0.72	-4.41	10	157	2010-03-03 16:48:16	2010-03-03 16:48:16	2	2	39	2	71	128	0	55.70	39	12.77	CHANGED	.Ltc-RsNlppAahELKEEhuRlphLupsQs-hLpKLshssssspp...QsssPIpCs-+	..........lhccpsNlppsahELKEEhp+lphLopsQs-hLpKLphssststt......................p.t.ssPlpCp-c.....................	0	3	6	21
+12685	PF12846	AAA_10		AAA-like domain	Bateman A	agb	Jackhmmer:Q180M9	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null --hand HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.84	0.70	-4.98	149	6551	2012-10-05 12:31:09	2010-03-04 08:58:08	2	39	2755	0	1413	9633	1186	297.10	16	39.53	CHANGED	ssshhlhGtsGuGKSshhp.thh..hthhttG............................splhll......Dht.scats.....hsph.......................hsuphlths...........hsss.........htlN.....Ph.....pht.........................................................hppptpthhshLtthhpths.stpt.................pshlsps..lptha...................ptths...............................................................................................................................................sls-lhch..lpp...t..........................................ptphpph.tp.........tlpthh..........sthutlFs....t.oshph..........ssplls..hclsslpts.............tphhshhhhhhhshhh..pphht.............................t...........ptppphlh...........lDEs.athhss.......s....thhphlpphhRps.R+hssshhhsoQsh.sDhhs...t.............pslhstsshthhhptss..pphtt......ltphh...sls.s	...............................................................................................................................................................................................................................................phhlhGsoGu.G.K..o.h.....hhp..hlh.......tt..h..h.h.h..s......................................................................sph.hhh.......D.....t.....sp.h.tt.................hsph........................................................hsuphh.p..h.s...............................ssp...................hthN.............Ph..........................th.................................................................................................tpphph....h..h.....s..h..l...t...h..h.h.t...htstthpt...........................tshl....p..ps.......lpth.h...........................p............................................................................................................................................................................slpp..lh..ph.....lp..pt..................................................................p.thtph..tt........................................................tl.p.hh..................st.ht..h..las................................ttss.h.ph...................psph..hs.......h..-..l...s...p..ltpp..........................................thhs.h.s...h...h..h...l..h.ph.hh.....pphht.................................................................psp.thlh...........lDEs.ath.lps....................t.........htp.h...lt.ph...h..+ps.R....K.hssth.hhsTQ...s...h...sD.lh.tt..................pslhpss...s.hh.lh.h.pp.sp..tp.t.....h.t.h......t..........................................................................................................................................................................................	0	450	933	1222
+12686	PF12847	Methyltransf_18		Methyltransferase domain	Bateman A	agb	Jackhmmer:Q18BX6	Domain	Protein in this family function as methyltransferases.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.66	0.71	-3.49	195	8520	2012-10-10 17:06:42	2010-03-04 15:04:54	2	133	3477	116	2843	74852	20479	109.50	19	36.69	CHANGED	sst..pl.lDlGsGsG..phs...lthsp..........stp..lhul.........Dh......stphlphsc..........................pps.........................................tht....splp.....hhp....................uch........hsthst....................................hDh..............lhhss...............hhph......................lp..phh....ptLp.................................s.uGh........lllssh	................................................tpl..lDlG.s.G...s...G......p..h.s......l..th..sc.................................t.u.tc.......lhu..l.....................................Dh.........................u..s...t...h...l...p..h...s.c...........................................................................................................................pph........................................................................................................t......hths.......sp.lp................h.lp...........................................................u.-h..........t.h.s.h.h.tp..........................................................................................hD.h............................l..hh.st.....................................................hhsh....................h...........................lp.....t.hh...............ptLp................................................s...u.Gh...llh...hh..........................................................................................................................................................................................................................	0	981	1879	2441
+12687	PF12848	ABC_tran_2		ABC transporter	Mistry J	jm14	Pfam-B_38684	Domain	This domain is related to Pfam:PF00005.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-9.97	0.72	-4.14	246	15857	2012-10-05 12:31:09	2010-03-04 15:58:16	2	25	4624	0	3551	11380	1770	86.00	24	14.83	CHANGED	l-l-puclp.tYpG.NYspahpp+ppchptptptacpQQcclp+hppaIcRh+.s...pu........s+up....pAp.SRhKtL-+h....-p...lcts.....p.c....tt..p..hpF	......................h-l-pGcl.p.Y.....p.....G...NYspahcp+ppph...pppt.......p.p....pcppcplpc........p.sa.......lc..+ht.t.........................................u+sp........pu..p...uR....h+tl-....+h........cp....hp..................................................................................	0	1158	2264	2991
+12688	PF12849	PBP_like_2		PBP superfamily domain	Bateman A	agb	Jackhmmer:Q180B2	Family	This domain belongs to the periplasmic binding protein superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.99	0.70	-4.94	148	7526	2012-10-03 15:33:52	2010-03-05 19:02:32	2	29	4026	39	1757	5461	2312	251.70	21	78.69	CHANGED	sssssstsh................................................lhsssooshtshhh....p.hhts..............Fppp.ssh..............................p...........lp................h...tusGoupulpthppG....................................sDlshss..t....thscpch..ts.......................hshpt..........hslshssllllss.ts........................ssst.t.....hsspsltpIht.t............................................................................sstslthhh..RucsSG.....h.sphtpt.............................................t.ht...................ttsh...................................................stsht.s................ps.sGhhsslshssth....t.........shshss.....tshhhsh................ts.hph..............................t.....hhs.........spt.....GsaPlhpsh...hhlhhssthh..........tstsps.......Fhsahh.Ssc	................................................................................................................tst.........................t....................lpss.G.o.....osh.t.s..lhp..t..hspt.......................................atp.p...s.s.s................................................p.................ls................................h......pusG...S.us.Glp.p.h.h.sGs...................................................................sDhusus.....t.......................shpp....p..ch.....................................................thhp..h...l.........uhs.........u.....lslslN..hs.................................sslp..t.......Lo.t.pp.lt....p..I....a...t..Gc.....................l........................................ppWpp.........................................h.thss.ppIt.llp....R.ss.s...S.G..TpthF.pphlhp.t...........................................................................................................................................t.ht..........................................t...............ssshtth.........l............pp..suulua.lphu..h...........................................h......................t............................................tpthph.....................................................hts.....................h.tpsht..sssa.P..l..hp.h...ahhsp.p.p...................sttspp.....Flcahh.s..t......................................................................................................................................................................................................................	0	550	1144	1508
+12689	PF12850	Metallophos_2		Calcineurin-like phosphoesterase superfamily domain	Bateman A	agb	Jackhmmer:Q180F1	Domain	Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.18	0.71	-4.39	139	12839	2012-10-02 19:15:56	2010-03-08 14:03:49	2	60	4473	32	3683	17996	3872	206.20	16	75.47	CHANGED	M+lullSDoHs..................h.c............h...p....................pll.c..th.....p..p....s-hllHsGD...........................h.....s.............s..............p..l....hp.h.........pp.h...s........lhsVpGNs.............................................D........................tt......h....s.pph................................................................hhpl.s......................sh...................ph.hhsHG.........pt......ht......................................................................h..........ht....p..t.......lh....ttsp.pt.sscll.hhGHoHtsth........................p..p......hs..s...hlhlNPGSsshs+.............ht.........t...ohsllclpss	.......................................................................................................................+lhhlSDl...Hh...............................................s.h..p......................t.......h...p................................................p.ll...p..th...............p....p...............sD..h.l.lhs.GD.............................................................l....hs..............................t.........................................................................pph...........hc.tl.................pph..........s.............lh.h.l....t..G..N..c.................................................................................................................D.............................................t..........h...t.......h.....................................................................................................................................................h.......h..p.h.t..........................................st.........................................p.l...h..l..s.H...u..............p........h.s.........................................................................................................................................................................................................ht........................h.s.....p....t....................h.......t.hht....p......t.....s....s....c.....h..h.....l......h..GHs..H....t....s..th.......................................................................h............t.t............h..h...h........s....G...s..................................................t.......................................................................................................................................................................................................................................	0	1293	2430	3172
+12690	PF12851	Tet_JBP	TET_DSBH;	Oxygenase domain of the 2OGFeDO superfamily 	Bateman A, Zenonos ZA, Iyer LM, Aravind L	pcc	Manual	Domain	A double-stranded beta helix (DSBH) fold domain of the 2-oxoglutarate (2OG)-Fe(II)-dependent dioxygenase (2OGFeDO) superfamily found in  various eukaryotes, bacteria and bacteriophages [1]. Members of this  family catalyze nucleic acid modifications, such as thymidine hydroxylation during base J synthesis in kinetoplastids [2], and the conversion of 5 methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine  (hmC) [3], or further oxidation to 5-formylcytosine (5fC) and  5-carboxylcytosine (5caC) [4]. Metazoan TET proteins contain a  cysteine-rich region inserted into the core of the DSBH fold.  Vertebrate TET proteins are oncogenes that are mutated in various  myeloid cancers [5]. Fungal and algal versions of this family are  linked to a predicted transposase and show lineage-specific  expansions [1].	26.00	26.00	26.00	26.00	25.90	25.30	hmmbuild  --amino -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.99	0.71	-4.97	25	327	2012-10-10 13:59:34	2010-03-09 14:18:29	2	10	97	0	200	301	87	374.70	27	38.59	CHANGED	uhshhhsshhpsp............h.s.hht.t.p.......htphlpphsshlsslhctlsPphapttsphhsshh................hh.hhupsaoshols...............psptst.H+Dptsh.tshslhsshtts.........hcGGtltlsp........................................................................................................................................................................................................................................................................................................................................................................................................................................................huhslsspsGslllhsuphhhHussslps..................................................................stRholVaah+c	...........................................................................................................................................................................................................................................................................................hYashpt.sp.......p..sR+hch.hpp.tt...................................lcpphpplushluslYcpluPptaps.Q.h.phpphs..c..scl..............sh.p.GpPFSGlTss...............hcFss+sH+Dh+shts.G.hol.lsTLscpp..............p--phal..LPh..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hGluls.spGolll.su+h.hHusTs.lc.p............................................................s...p..pspRlolVaY.+c........................................................................................................................................................................................................................................................................................................................................................................................................................................	0	64	106	140
+12691	PF12852	Cupin_6		Cupin	Mistry J	jm14	Pfam-B_918 (release 24.0)	Domain	This is a family of bacterial and eukaryotic proteins that belong to the Cupin superfamily.  Some of the proteins in this family are annotated as being members of the AraC family of transcription factors, in which case this domain corresponds to the ligand binding domain.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  --amino -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.12	0.71	-4.68	212	1675	2012-10-10 13:59:34	2010-03-10 15:02:53	2	5	1105	0	494	1685	112	171.80	25	57.25	CHANGED	DsLSc.lLstl+hpushhhpsphsusWul....ph....s...ss...............hphahlhcGpshlp..ss....t.....s....lpLss.GDllllPps...p....sahl....s...ssss..................................................................ts.....................s.s...............................stllsGphphcssts....p.LlssLPsllhl...t...............t..tshlsshlphlttEstpspsGpphllsRLh-lLhlpsLRtalp	.........................................................................................................DsLoc.LLphhp...pusl..tps..h.su....sWtl......th......sst.................t..s........hpaH.h.......lhpGs.shLp..hss..................s......p.....hpLpsG-ll.llPps...s..sHpL.....s...ssss..................................................................................................p..............................................................sspllCGphphp.ps.st.....t.llsuLPchlhl........................ss.tshLpth.lthLtpE........upp.....s.t.sGsssll.spLssslhshslRtal.....................................................................................................	0	123	263	390
+12692	PF12853	NADH_u_ox_C		C-terminal of NADH-ubiquinone oxidoreductase 21 kDa subunit	Coggill P	pcc	manual	Domain	This family is the C-terminal domain of NADH-ubiquinone oxidoreductase 21 kDa subunits from fungi.	25.00	25.00	49.60	48.50	20.50	19.90	hmmbuild  --amino -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.13	0.72	-4.28	10	102	2010-03-10 16:33:19	2010-03-10 16:33:19	2	2	99	0	80	97	0	77.00	57	40.60	CHANGED	hhEhhcKlpcGcs.Y..GpSpLsshhQslAsRNSpYStLhlaVlPWFNhsNHs.HGVDhsKYYpptEtEhE................Acpst+tt.p	............M+EMVcKlKcGcPLY..GpSpLosahQGVAARNSRYStLFhpllPWFNhVNHsQHGVDTAKYYpQAEcELE...........................sEp.........	0	20	44	68
+12693	PF12854	PPR_1		PPR repeat	Wood V, Coggill P	pcc	Pfam-B_105542 (release 24.0)	Repeat	This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. The exact function is not known.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.49	0.72	-4.47	433	3378	2012-10-11 20:01:03	2010-03-11 14:22:50	2	1621	145	0	2261	22733	138	33.10	30	7.47	CHANGED	pGhpPsslTYssLIsGhC+sGclccAhclhccMp	..........................shtPssloY.....ssL.ls.u.h..C..+...s...G....c.lccA.hc.lhcpM...................	0	277	1399	1896
+12694	PF12855	Ecl1		Life-span regulatory factor	Wood V, Coggill P	pcc	Pfam-B_42039 (release 24.0)	Family	This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation.	26.40	26.40	26.50	26.40	26.10	26.30	hmmbuild  --amino -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.91	0.72	-4.66	23	165	2010-03-11 15:50:29	2010-03-11 15:50:29	2	2	112	0	132	156	0	43.20	35	21.05	CHANGED	Mu....AFssYChsC-+lh........................sssplYCS-pC+ppDpppshsttp	..............F.paChsC-+Qh.....................................ssstlYCSEsCRhtD.pps......t............	0	28	66	113
+12695	PF12856	Apc9		Anaphase-promoting complex subunit 9	Coggill P	pcc	manual	Family	Apc9 is one of the subunits of the anaphase-promoting complex, or cyclosome [1], which is essential for regulating entry into anaphase and exit from mitosis. The APC is a ubiquitin-protein ligase complex. All APC subunits are members of the cullin family proteins, which bind to a ring-finger subunit via a conserved cullin domain [2]. The APC is made up of four parts, the third of which is a tetratricopeptide repeat arm (TPR) that contains Apc9 [3].	25.00	25.00	28.70	26.80	24.30	24.30	hmmbuild  --amino -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.73	0.72	-3.92	15	42	2010-03-12 10:19:30	2010-03-12 10:19:30	2	2	40	0	25	35	0	117.30	28	33.36	CHANGED	ssslcs+lhslppscKpt..............................h.tpstp.spYDYulF.scpss.............l+ESpIcuapsuE+hspsllFcps........s.psD.....s..............pssc.ctsp..........tptshl...slPGYTp	...........................................................h....hsh.hslppsph.t..............................slpc...tp.tppYDYSsF.sccss.............l+ES+Icua.pAE+ss+sLlFc+st..................................S.csDh................s..........ppssc.-psp............tssshll..SlPGhsp..................................	0	4	14	24
+12696	PF12857	TOBE_3		TOBE-like domain	Mistry J	jm14	Pfam-B_1384 (release 24.0)	Domain	The TOBE domain [1] (Transport-associated OB) always occurs  as a dimer as the C-terminal strand of each domain is supplied by the partner. Probably involved in the recognition of small ligands such as molybdenum (eg Swiss:P46930) and sulfate (Swiss:P16676). Found in ABC transporters immediately  after the ATPase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.57	0.72	-4.11	101	1134	2012-10-03 20:18:03	2010-03-12 10:22:48	2	2	1112	0	221	704	35	57.20	31	16.08	CHANGED	sssp...sslsu.plpplp.shGshs+l..El...phh....ssp.........hlElclspcp......t.thht.GpplhlpP+	...........ps..hsuslPs.pVlcssPhGthspl...l......psh.....hhs-..........lpl.hst-c........s.pt.G-plals................	0	46	110	166
+12698	PF12859	Apc1		Anaphase-promoting complex subunit 1	Coggill P	pcc	manual	Family	Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex [3].	25.00	25.00	27.00	26.70	20.50	20.20	hmmbuild  --amino -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.48	0.72	-3.81	57	240	2010-03-12 11:41:32	2010-03-12 11:41:32	2	3	221	0	182	249	0	101.60	27	6.01	CHANGED	csLsVlh..psphplahh...s........GcsaslsLPFp.Vsssashsp..GLlLpRchs...................ssphtttt.............................................................................sshs+l.aoL...scPLsEhs.Vshps	................................slsllh..psphplahh...s.........GcsallsLPFp.Vsslass.th..GLLlpRpts........................................spphs.sss............................................................................................................p..........pshPph.aoL...hcPLsEhs.llhp.......................................................................................................................................	0	57	95	148
+12699	PF12860	PAS_7		PAS fold	Mistry J	jm14	Pfam-B_21375 (release 24.0)	Domain	The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs [4]. The PAS fold appears in archaea, eubacteria and eukarya.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.19	0.71	-4.08	164	2444	2012-10-04 01:10:46	2010-03-12 13:50:07	2	265	808	0	913	2460	395	113.00	23	15.73	CHANGED	LcphsQGlslaDs-h+LlsaNp+atclaslPsphl.psGts.hpcllca...spcGphu....sc......h-th....lppcl....p.thpp...tpsphhE+pp.ssGpllclpusPh....Ps.GGaVsoaoDITp..p+cu-p	.....................l-plspGlslaD.sctRLlhhNppa.t.cl.a..s.l..s..s.shl.........p.s.G..hs...hp.p.l.lc.ht....tppu.hhs.........tp........................hpph..........h.pph.h................t..t.hpp.....sps...p..p..h..p...h.p.h..sD.G..+............h..l..c....l..psp..s.h............s...s.....G......G......h....V.....h....s.ap.DlTphpptc............................................	0	225	493	644
+12700	PF12861	zf-Apc11		Anaphase-promoting complex subunit 11 RING-H2 finger	Coggill P	pcc	manual	Family	Apc11 is one of the subunits of the anaphase-promoting complex or cyclosome [1]. The APC subunits are cullin family proteins with ubiquitin ligase activity [2]. Polyubiquitination marks proteins for degradation by the 26S proteasome and is carried out by a cascade of enzymes that includes ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. In Saccharomyces cerevisiae this RING-H2 finger protein defines the minimal ubiquitin ligase activity of the APC, and the integrity of the RING-H2 finger is essential for budding yeast cell viability [3].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  --amino -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.35	0.72	-4.15	5	247	2012-10-03 15:03:13	2010-03-12 14:30:41	2	9	213	0	172	3252	290	81.50	49	56.19	CHANGED	MKVKIpEW+uVATWpWDlPs.................DDVCGICRVuFDGTCPsCKaPGDsCPLVlGp.CsHsFHhHCIh+WLcspoSKGLCPMCRQoFphp-	.........................................................MKVpIp.p...Wpu.....VAsW.pW.t..hsp........................................D-sCG..IC..R..hs.....F.....-.....G..s......C.....P......s..C..............K........h........P........G........D.......D.............C..........P....L......l..h.....G............p........C............s..Hs......FHhHCIh+W...l.p....p...p......p.....s....p....t........CPMCR.ppaph...........................	0	56	98	141
+12701	PF12862	Apc5		Anaphase-promoting complex subunit 5	Coggill P	pcc	JCSG 	Domain	Apc5 is a subunit of the anaphase-promoting complex/cyclosome (APC/C) which is a multi-subunit ubiquitin ligase that mediates the proteolysis of cell cycle proteins in mitosis and G1.  Apc5, although it does not harbour a classical RNA binding domain, Apc5 binds the poly(A) binding protein (PABP), which directly binds the internal ribosome entry site (IRES) of growth factor 2 mRNA. PABP was found to enhance IRES-mediated translation, whereas Apc5 over-expression counteracted this effect. In addition to its association with the APC/C complex, Apc5 binds much heavier complexes and co-sediments with the ribosomal fraction [1,2]. The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC [3]. This region of the Apc5 member proteins carries a TPR-like motif.	21.00	3.90	21.00	4.60	20.90	-999999.99	hmmbuild  --amino -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.05	0.72	-4.15	26	461	2012-10-11 20:01:03	2010-03-12 16:08:58	2	64	292	0	278	1604	191	89.20	21	16.11	CHANGED	aalpYLpulpsp-Y.sAl-sLHpYF...DY..hhppsscs............................................tYpaA...LLsLAhLHspF...GctccAlpAlpEAlplARENpDpssLsahLsWlhphhcpp	.........................................................................................................................................................................h..t.ph.tuhp.Lhphh.....Dh.......t.tpt.........................................................................................hp.h.A......hl.s..L.A..t.l.ps.ph...Gph..ppA......hts....lpEAl...pl....Ap..c....sp....D.......s.Lthhh.hh.......t..............................................................................................	0	95	155	224
+12702	PF12863	DUF3821		Domain of unknown function (DUF3821)	Coggill P	pcc	manual	Domain	This is a domain largely confined to sequences from Methanomicrobiales found on putative lipases. The function is not known.	20.80	20.80	21.00	30.30	20.50	19.40	hmmbuild  --amino -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-11.47	0.70	-4.66	20	31	2010-03-15 09:40:29	2010-03-15 09:40:29	2	7	7	0	23	31	0	210.70	28	29.50	CHANGED	sGusVFlGEpGLDlosshs......ssspIuWassuss................................ssssPsphhslss..spsFaVsPshFssps....GsWYthssp.t.........sssFpVc-PslulclhDtsssp-lo..spslspGshlsFpI..cTNLtuh...tpRsusssss....lsIplp........sPsGssassLhss.sGssps................Lssls.....Vss.....................ss.tss..suWsTush.ssust.Y.psGsYslhAcsslNsht-	..GssVFlGEpGLDlosshs.......ssspIuWassGsss...............................ssssPsphhslss..sssFa.VsPshFsscs.....GsWYthsss.t..............ssuFhVp-Pslulcla.Dhs...s..s...pDlo..spplspGshlsF+l..-oNL.ul...hpRsusssss....lsIpVp........sPsGsshosLhss.sussts...........lssls.....lss......hah................tt..suasossh.spssp.Y.psGsYpVhAcsslNsMtD..........................................	0	11	23	23
+12703	PF12864	DUF3822		Protein of unknown function (DUF3822)	Coggill P	pcc	JCSG_pdb_3hrg	Family	This is a family of uncharacterised bacterial proteins. However, structural-similarity searches indicate the family takes on an actin-like ATPase fold.	20.40	20.40	21.60	21.00	19.90	19.30	hmmbuild  --amino -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.50	0.70	-5.15	46	193	2010-03-15 14:40:07	2010-03-15 14:40:07	2	1	190	1	54	196	147	238.40	24	89.79	CHANGED	Mt.t................phshpptp.hp....LSIplshcGhSFsl.....hss.spphhhhpphphp....sstpltpplcphhcpp.phLppsacpVpllhssshaThVPpsLF.-ccphssYLpa..s..hhps-hltach.ltp.shssVash.pslpsalhcpass...hcahHpsosllcthh..pts.pstppcplalplpcpph-lhlhcppcLlhhNsFp...hpo.......scDhlYYlLashcQLsls.-psplhlhGp..l..sc..csphaphlppYl+plp	................................................h................s..pppthp..LoIclutsuhSFsl.......hss.ppp..hhhpphphp....sshsl.tssLcphhppp.phLpp.s..acclpllhsss.hsllPhph.F.cc..cpt..pphhpa..shptpps-hlhhsh.Ltp.sssslashscslpphlp-pasp...hcahptsssllphhh...ppu.ttuspcclYsphcccph-lhsapps+LlhsNoFp...hps.......spDhlYYlLalacQLshst-cscLhLsGp..l....sc...c-plhppLcpalcpl.............................	1	22	47	54
+12705	PF12866	DUF3823		Protein of unknown function (DUF3823)	Coggill P	pcc	JCSG_target_3hn5	Family	This is a family of uncharacterised proteins from Bacteroidetes. It has characteristic DN and DR sequence-motifs. The function is not known.	21.80	21.80	21.80	22.20	21.70	21.70	hmmbuild  --amino -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.61	0.70	-4.84	28	92	2012-10-02 19:08:27	2010-03-15 16:51:00	2	1	54	3	14	85	2	225.90	25	92.24	CHANGED	hllhhhhs...hsuCp...h.DNY-.tPcutlpG+l..hhsGEslthch....s..usplplappG..a.s...ph..sshslhlppDGoa.sshlFsGsY+llhhpGsh..............stDolp...lslp.Gs.sphDhcVpPYhhl..cssshshsGsplsAoFplppssss.....slccltlalspophVs............s..thsptt.shsshhs.sp.hohplslsps...............pshhasRlGspsssstph..YSpll+l	.....h.hlhhhhhhsSCp...h.DN.YD.tPp..uslpGcl..hhsGEhlthch....s....usplplhphG..au....pp.....ss.shhlppDGoa.sshlFsGsYclhh.pGsh.............hstDTlp...lplp.Gs..sph-hcVpP...Yhpl..pssphph.s...u...splsApaplppssss..................slpcltlalspsphVs....................spphspts.p.hssths.ss.hshphs...lsss....h.s..........tpphasRlGspss.s....s...p....ph.....YStshcl...................	0	6	13	14
+12706	PF12867	DinB_2		DinB superfamily	Bateman A	agb	Jackhmmer:P72629	Domain	The DinB family are an uncharacterised family of potential enzymes. The structure of these proteins is composed of a four helix bundle [1].	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  --amino -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.64	0.71	-3.79	220	3722	2012-10-02 14:44:17	2010-03-16 10:45:46	2	34	1437	16	1256	5855	770	137.90	14	54.56	CHANGED	th..ppsh.p...phhph..lp....sl.....s.p......pphphp..s...................................s.sst................slt.hltHlsh.....spp..hhh....tp.ht................................st.................s.....................................h........tht.ht.h.......................................s...........shs.pl........h...phhp.phppphhphlps..h....st..tp....h...pp.h.....hh.....................................................t.h......s........htphlth.hhtHptpHhtpl	..........................................................................t.th.ph..hp....sl.....s..p.......pp..ht.hp...s..............................................................................t..stt......................................olt.hlsH.l.sh........hpc...hhh....hp.ht.....................................s.p...............t.s..........................................................h........t.htp.t.p.h.............................................shp..pl...........h...p.h...h....p.p.s....p.pph...h...p...hl....ps...h.........st....tp.......h.....tp.h.......................................................................................................................h.............s..............h.t.t.h.l.h.h..hhtHptpHhtph....................................................................................................................................................	0	533	952	1146
+12707	PF12868	DUF3824		Domain of unknwon function (DUF3824)	Coggill P	pcc	manual	Domain	This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.	22.70	7.90	22.90	7.90	22.00	7.80	hmmbuild  --amino -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.29	0.71	-3.24	11	83	2010-03-16 14:05:24	2010-03-16 14:05:24	2	6	42	0	63	89	0	114.80	25	27.75	CHANGED	+pRSRoRDLApAALAAsG.lGYAAHKYo.QRp-RKKt-+ER-+.+aDcD.hppSYt-sY.sPhPYssoP........sssspYYPpoNaFPPPPGosPs..ssssstP.sYNPADYPP.......P..PuAs.sP.psYsY....Pss..PusDsYAPRPRRADENV	......................+SR...sRp........huthul..AAAG....hG...hA..A..tp..hp..p++-+K.........cp-..+cR...ccpcpccc.hppuhpp.s..h..ss.ts..ssss...............st.t.h...st....ssh.as.PPs.t........................................................................................................................................................	0	9	22	47
+12708	PF12869	tRNA_anti-like		tRNA_anti-like	Coggill P	pcc	JCSG_target_390051_3f1z	Family	This is a family of bacterial, archeael and viral proteins that is related to the tRNA_anti family Pfam:PF01336. The major characteristic of families like tRNA_anti is their OB-fold, and many of them bind DNA.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.93	0.71	-4.71	25	205	2012-10-03 20:18:03	2010-03-16 14:53:54	2	8	185	10	48	201	46	146.90	15	77.05	CHANGED	Mt............pphlhhhlhl............hhluhlhs...............................sh.spsphsstptpssh...............shsu.ppLhspapcNpspAsppYh.....sKhIpVpGslssI.pc.tttsss..llhtpp.ts.sslhCphsssp.............ts..lppGpplplpGhspGht...........hsslhLcssh	.....................................................................................................................................................................h................hh.hhh...............................................tttt..h..............................................hss.s....plhpsa.p.p.Nt.h.......sA.......s......p.pY.p......sKhlpl.s.G.pl....t..sl..pp..ttssph......hsh.h.s....s..t..t..s........h..sl....p.sthsssp....................t..t.......lppGpplslpGhhpsh.....................h...............................................	1	17	31	40
+12709	PF12870	Lumazine_bd		Lumazine-binding domain	Coggill P	pcc	JCSG_target_391926_3k7c	Family	This is a family of putative lipoproteins from bacteria.  Many members of the family are defined as having a lumazine-binding domain. Lumazine is a fluorescent accessory protein having 6,7-dimethyl-8-(1'-D-ribityl) lumazine (DMRL) as its authentic chromophore; it modulates the emission of bacterial luciferase to shorter wavelengths with increasing luminous strength. The family is related to the NTF2-like transpeptidase family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.32	0.72	-4.02	26	650	2012-10-03 02:27:24	2010-03-16 16:51:30	2	9	571	4	86	427	52	96.70	23	43.48	CHANGED	suC..ssssPpps....scpahcsltcGchcchhchhs.pspp..........th.thhcthspphppphpphtuhc.hcl.ppp.....sspApVplpssatsupppppshpllK.pc.spWplp	...................................................hs...............................t...p.tth.t....................................................................pl....cp.l...cVh-+s.........sDsAcl..+Vch...s......h........s......s.....s........s..s..p......p......p..p.......l.........L...+...c-...upWcl.h............................	0	35	67	79
+12710	PF12871	PRP38_assoc		Pre-mRNA-splicing factor 38-associated hydrophilic C-term	Coggill P	pcc	manual	Domain	This domain is a hydrophilic region found at the C-terminus of plant and metazoan pre-mRNA-splicing factor 38 proteins.  The function is not known.	22.40	22.40	22.50	22.50	22.30	22.30	hmmbuild  --amino -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.35	0.72	-11.34	0.72	-3.46	72	139	2010-03-16 17:36:41	2010-03-16 17:36:41	2	24	85	0	82	113	0	102.60	25	19.68	CHANGED	s+sssh......c...pc.h..p-tp..ps..p..-...cpt.ccs....s......p......cs....s..ts.hs..ttp............p.s.s..cppsRspp.........................ps..pc.p.ppp...pp...p+p.cs.......cs..pp..R..p+spt......p....pc+....-+....p...Rp.+..sRs...R.......sRsR.D..Rpcc	............................................................................h..shc...ts.hpp.ppt..p..-....-pt.pp................ps....s....s...sp..htp...........................p...tspsRpps...........................................................ph+p.ptp.s.......cp.......sRc..Rs..................+s......pcR.c+sp.......p.....+-R....-R....s.Rc...+.cRc...R...sR.sR.DRcc.t........................	0	19	37	59
+12711	PF12872	OST-HTH	OST_LOTUS;	OST-HTH/LOTUS domain	Bateman A	agb	Aravind L	Domain	A predicted RNA-binding domain found in insect Oskar and vertebrate TDRD5/TDRD7 proteins that nucleate or organize structurally related ribonucleoprotein (RNP) complexes, the polar granule and nuage, is poorly understood [1][2]. The domain adopts the winged helix-turn-  helix fold and bind RNA with a potential specificity for dsRNA [1].In  eukaryotes this domain is often combined in the same polypeptide with protein-protein- or lipid- interaction domains that might play a role in anchoring these proteins to specific cytoskeletal structures. Thus, proteins with this domain might have a key role in the recognition and localization of dsRNA, including miRNAs, rasiRNAs and piRNAs hybridized to their targets. In other cases, this domain is fused to ubiquitin-binding, E3 ligase and ubiquitin-like domains indicating a previously under-appreciated role for ubiquitination in regulating the assembly and stability of nuage-like RNP complexes. Both bacteria and eukaryotes encode a conserved family of proteins that combines this predicted RNA-binding domain with a previously uncharacterized RNAse domain belonging to the superfamily that includes the 5'->3' nucleases, PIN and NYN domains [1].	25.00	11.50	25.00	11.60	24.90	11.40	hmmbuild  --amino -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.54	0.72	-4.14	234	1690	2012-10-04 14:01:12	2010-03-17 11:05:37	2	67	816	6	797	1608	60	71.30	17	19.68	CHANGED	pt.ppltphlpphl..tpspcp....sG.hspluplssphppph..ssFcs+sY..........GappLscLl.p..s.hsch.hcl....ppttssphhl	......................h....thtp.lhpll...t..pttst........t.hh.lupltsphpcph..shs.psY..........GapplpcLl.p....u..hssl..hcl.....tpttt.....hh.......................	0	219	388	594
+12712	PF12873	DUF3825		Domain of unknown function (DUF3825)	Aravind L	agb	Aravind L	Domain	Potential uncharacterized enzymatic domain associated with bacterial Pfam:PF12872 domains.  Has conserved residues suggestive of an enzymatic role probably related to RNA metabolism.	27.00	27.00	30.20	29.50	23.50	21.40	hmmbuild  --amino -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.72	0.70	-5.22	20	92	2010-03-17 11:31:21	2010-03-17 11:31:21	2	5	85	0	15	78	3	224.80	31	63.68	CHANGED	ppLuplAts.E.........sWthsps........pshsILcsYlphTFpRlhcpsp..............hhhssssspusFNTGLlopptcsIaAlFppsp.........................................tsttsWhhpuFs............tsptphhhpshsplP.shusYac.csp-llF..Dsc.tclpls...h-HI..hs-ph..-RhPsphppht....................................cptltshlpuAlchstp+spRNY+hAVPpaYp.......s+lphLLPlpL...spssps-hALslp+..scph....YcupTILTL.chAYpNARLls+P.-scW	....................................................................LtplA....E...Wt.tss...............ILhsYlhthFpplhcppp..............hhhstcps.hAsFNTGLhopth.psIauhFpppp...........................................pttahFpt....Fh.............pptt.hh....plP.phusY..s...t..p-..llF......Dsc...hshpls...h.Hl..hppp...cRlPphlpphs...........................................cphltphlpuslc.......hhtcphphs.+hslPtaYp.......p+l.lhlPLpL...........ppppsDhslVlc+....ppst....YtspTILs..c.sYpsARllshs.-spW................	0	7	11	15
+12713	PF12874	zf-met		Zinc-finger of C2H2 type	Coggill P	pcc	manual	Domain	This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.	21.10	13.30	21.10	13.30	21.00	13.20	hmmbuild  --amino -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.71	0.73	-7.09	0.73	-3.60	388	5348	2012-10-03 11:22:52	2010-03-17 11:37:56	2	907	368	3	3248	16868	203	24.20	29	5.85	CHANGED	hh..CplC.phphsspsshpsHhpu++H	............h.CplC..phphsopsp.hptHhpuppH............	0	719	1232	2244
+12714	PF12875	DUF3826		Protein of unknown function (DUF3826)	Coggill P	pcc	JCSG_target_393061_3g6i	Family	This is a putative sugar-binding family.	25.00	25.00	170.90	28.90	20.00	19.80	hmmbuild  --amino -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.20	0.71	-4.60	7	68	2010-03-17 11:40:38	2010-03-17 11:40:38	2	2	39	2	14	57	0	174.70	46	54.17	CHANGED	tYlcsl.pRupKIVspLslsDssttppVsplIAN+YhcLsDIaptRDs+lKtlKcsh.LststpppAlcttphctDAsLh+sHhpa.ApLShhLs-cQI-tVKDGMTYGsl.lTYcuh.DhlPoLTEEEKtpIatWLsEAREaAMDAcsScKKHAhFsKYKGRINNYLuK+GYDLpKEpc-WhcRhcu	........t.stSl.p+utcIVspLtLsDsptuppVtslIsN+ahclpDhapt+st..ppl.Euh..ssstt.ptLctt.htcsAthhcsHhta.ssLshhLs-cQIEtlKDtMThGhVthThcua.-hlPsLpEEE+upIhtaLhEAREhAlDhcNspph+AhFsKYKG+INNYLsc+Ghsh+pttc-ahc+hKA.....	0	9	14	14
+12715	PF12876	Cellulase-like		Sugar-binding cellulase-like	Coggill P	pcc	JCSG_target_394744_3gyc	Family	This is a putative cellulase family.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  --amino -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.91	0.72	-3.54	18	341	2012-10-03 05:44:19	2010-03-17 13:25:12	2	18	274	2	102	613	180	89.30	29	19.74	CHANGED	llspatp-sRIlhWDLaNE.Ps...s...............h.s.ttsst...hct.hthLppshthhRslcPspPlTuGh......sss..........shss......hpplp..hpsl.DlIoaHsY	...........lspatsDsRlLhWDLaNE.Ps..s.t..............................t....ptst........hp...t....s....tp.Llppsh.pasR.slcP.s.Q.P.l.T.u..G.s..................Wps..................phss...................ls.thp......h.p.ps..Dl..loaHsY.............................................	0	39	77	90
+12716	PF12877	DUF3827		Domain of unknown function (DUF3827)	Zenonos ZA, Mistry J	zz2	jackhmmer:Q9HCM3	Family	This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34 [1-2].  Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion [1-3].	19.40	19.40	20.60	20.00	19.10	18.60	hmmbuild  --amino -o /dev/null HMM SEED	684	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.40	0.70	-13.18	0.70	-6.42	5	150	2010-03-17 13:51:21	2010-03-17 13:51:21	2	4	46	0	75	128	0	484.60	41	45.39	CHANGED	PhpPsP-upFQV+TVLQFVPuuVDlRhCsFoQphEKGLhpAa...tEVR+sopushNlTVpIlNIT...slSspsp.p+sPVsIlFAV+sspGFLNGT-VSuLLRQLSAVEFSFYLGYPsLQIAEPFcYPpLNlSpLLRuSWV+TVLLGVh-pplss+sFptohER+LAQLLuElhshu.ppRhRFRRAToVGNsoVQlVpsoRLsGPDNPlELlYFVEttNGcRLsAsuoAclLNolDlQRAAIlLGYRVpGllApPV-+QAcPss-opPNNLWIIlGVVlPVLVVslIIIILYWKLCRo-KLDFQPDTluNlQQRQKLQ.PSVKGFDFAKQHLGQHuKDDlhlIp-PsPL.ss.hccsoPuEsu-lPoPKSKus.pcuoopssR+RGclSPS-uDSpsS-suSsRuus-cusRsussPusssQQ+so+ccupptssPuSGhDEsLSSuSIFEHVDRlSRsuuDus+RlSuKIQLIAMQPMPAPPl.s...s.csStsD+As-NuKVNKEIQsALRHKSEIEHHRNKIRLRAKRKGHYDFPusEDlpuuhGD....spEp-RlYppAQ.QIcKILcPs-cp..SsasEP+KSsRu+RSP+sRR++QsLNGsu...T-tD+DRLIpoDRDGTYR+sPGVcNpAYlusss.plP-spu.S.ocp........spGHsPS.PusLsoQPSIEEuRQQMH.LL--AFALsSPuS	..........................Pt.hhplpT.......VLpFVs.sssht.CpFsQhhEptL.hAh......thhh...ptp.s.hpl......................p.sVslhasVt.stpshLNGo.sS.pLLppLSs..huaYLsYPsLpIAEPhp.YPpLshSphh+s.WVh...T...V.....l.G.......Vspp.lt.p..ptphtRhhtQhLupl.......hht...t......hhh+tssshGs.sVQhVphpR..l.GscsPspLhYas...sGc.L.ustuucllsplD.QRhAlhLtahl..........h.tcPsscs.ssNLWlIsuV.l.hPlhVV..hlIllIlhhhLC....RpsK.-FpPDshhNl.QRtK.............VpGFDaAKQHLGQpstD-.hl.hp.ts.......l.................shP.csu...sp.+phh.......shphtppschp..S.cusSt.sup..Spcput.p.................s.tsht...pt+.pct.......tpt.s..............s..ss..pE...................ths.hs.....................u+s.s-s.cp..suplQLIuhpPhshPss.......p...tspsh.ssclN+.................AL+pKS-IEHaRNKl..RL+AKR+GaY-FPss-s.ps..tc....p...p+h.p...........chh...ssst...usahcs+p....R..phpsp.hRp+Q.lsuss...s-h-..h.hhhppspcGhhpps.ss...ps.hh.....tss....................s.st...........s.......s...s..hhsspPoI-csRppMH.LL--AFuLsuss....................................................................................................................................................	1	8	17	34
+12718	PF12878	SICA_beta		SICA extracellular beta domain	Finn RD	rdf	Manual	Domain	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  There can be between 1 and 10 copies of this cysteine-rich domain [1].	21.70	13.00	23.40	13.10	21.60	12.90	hmmbuild  --amino -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.91	0.71	-4.46	262	470	2012-10-01 20:19:39	2010-03-17 14:32:34	2	34	2	0	456	482	0	170.50	28	62.21	CHANGED	oLCsplpCAup+.a..........hpppptp....ssss.................s...sa.W..pp....hpsclppLhpphspstp....pps......sss.hCsphtsss...............tspspKpACpalsAGLc+l.h......................pt...ssus..................pssp.FcQTMGClhL+tYAKpl+c..pu...............hCsI.-p.......GIc+A....Fpps.p..shhpss......Cs.......sssssCh.Cph......csc..ac...s.CpIs	...........................shCsplpCsspp.a....hppp.ttt...tsss......................ssh.Wpp......hpsclppLhpplspstppss.....sss..hCsshssts..............tspspKpACphlsAGLcclh................ph.......ssss.....................ss..acQTMuChh.LptYAccl+cpu............tC....sI.-p.....GIccA....Fpps.sph.hpss........Cs.......sssssCh.Cph......cps...ac...sCpI.......................................................	1	0	0	0
+12719	PF12879	SICA_C		SICA C-terminal inner membrane domain 	Finn RD	rdf	Manual	Domain	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  The C-terminal domain is thought to remain in the erythrocyte, found juxtaposition to the single transmembrane domain.  To date, all full length proteins contain a single copy of this domain [1].	21.90	21.90	32.80	21.90	18.30	21.40	hmmbuild  --amino -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.66	0.71	-4.30	3	127	2010-03-17 14:33:42	2010-03-17 14:33:42	2	24	6	0	123	132	0	131.10	61	13.13	CHANGED	KYFG.LhR+tRRY...+RuPspAssPSVQEQlLDHVEEAG......PHEYRLVKERKPsSsPsRTKRS.......GtVNRRTIIcIHFEVLDECQKGDTQLNQKDFLELLVcEFMGSEhM.EEEQVPKEEVLMESlshclVPhE-.VPSLSSGFMV	..............................................................KYFGPLGKGG.RF...RRSPs-IP.GsSVQEQVLDHVpp.su........sHEYpLVKERKPRS..u..PTRTKRS...........GtVNRRTIIEIHFEVLDECQK.....GDTQLNQK.DFLELLVpEFMGSEh..M...EEEQ..........VPK.....E-..VL.....M.....E.....ul.....P..........h.....E......VPhE.....c.....VPsLGSshh..........................	0	12	12	17
+12721	PF12881	NUT_N		NUT protein N terminus	Zenonos ZA, Mistry J	zz2	jackhmmer:Q86Y26	Family	This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations [1-2]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [1-2]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS), both located towards the C-terminal end of the protein [1-2]. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [3-4]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation [3-4].	18.10	18.10	18.10	18.90	17.30	17.30	hmmbuild  --amino -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.29	0.70	-5.30	4	167	2010-03-17 15:11:40	2010-03-17 15:11:40	2	10	28	0	77	136	0	260.30	49	37.96	CHANGED	sh.GPsMohpPGsuLSsFsALPFhPPsPsPscpP.hEPss.PllsushSPuNPLlLSAhPSs.LVTtpGGsu.SuAGsupVhVpl+T-sGPscsuQsQNllLTQssLshpsPGs.CGGltsP.PP.alTAusVpsllsupsVGsoQ..EG....GLPh..ssPPsAQLsPIVs.tpuhPsPpGspGEGGPsus.ppsS.sDhupts+uVYENFRpWQ+YKsLARRHLsQSPDsEALSCFLIPVLRSLARhKPTMTLEEGL.RAlQEWp+TSNFDRMIFYEMAEKFhEFEAtEEMQIQpsQlMpGsQsLsPsss.+LDP.Gs.APEVspQPVY	...............................t.shshpPusu.ss.ssLPh..PsssPscts.........s.h.ssshsPssPLhL.sshPps.LVstpsu...s...sus..Gssp.lhlph+o-stsspsspsQshlLTQssLshpAPGs...CG.Gs.sP.sP.hhlsAuss..shhsups......lG.soQ..s..-G..s.G....LP.....sPPPsAQLsPIl.s..puhPhPpGspu...EGu.sss.pt.u.sDpSspsKSVYENFRhWQ+aKsLARRHLPQSPDsEALSCFLIPVLRSLARhKPTMTLEEGL.hAhpEWp+pSNFDRMIFYEMAEKFhEFEAtE.......E.......MQhQ.......p........Q..hhpGspshsPsss....+h-P.GssAsclspQPs...................................	1	8	9	20
+12722	PF12882	NUT_C		NUT protein C terminal	Zenonos ZA, Mistry J	zz2	jackhmmer:Q86Y26	Family	This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations [1-2]. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4 [1-2]. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localization Signal (NLS) [1-2], both located C-terminal to this domain. A fused NUT-GFP protein showed either cytoplasmic or nuclear localization, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus [3-4]. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation [3-4].	18.10	18.10	52.90	20.10	17.60	17.90	hmmbuild  --amino -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.77	0.71	-4.59	5	230	2010-03-17 15:28:47	2010-03-17 15:28:47	2	8	26	0	96	163	0	127.70	39	25.81	CHANGED	PRL+ssRPQ+PPps+sPpEIPPEuVKEYlDIM-.L.G....hTGEScs.+EE-G.spssQEE--LPuDstLLSYpc+LCSQKlFVSpVEAlIpPQFlu-LLSP-sptD.LALppsLEQEEGLTLAQ...LlpK+pPsLcccusAEAsPs	...............................................th...+sp.p.PspsctPp.hPs.ssp-hhDIMp.h.......sG-s.s.pppct..p.tpp.E.E.-.th.sDssLLSYhccLCSQc.FlopV.EAlIcPpFlppL.LSP-sphD...hA....LppcL..EQE..EGL.olAQ..............lhpK.+hh.hcp.t.sct.sP.........................................	1	14	14	23
+12723	PF12883	DUF3828		Protein of unknown function (DUF3828)	Coggill P	pcc	JCSG_target_392985_3kzt	Family	This is a family of bacterial proteins of unknown function.	24.40	24.40	24.50	24.50	24.00	24.30	hmmbuild  --amino -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.51	0.71	-4.19	23	492	2010-03-17 15:29:03	2010-03-17 15:29:03	2	4	451	2	44	225	5	115.80	42	47.98	CHANGED	P-s.sspsFYpaY..lpphsp......spsshtssss.....lccYVupsslpcLpt..ph...pp-hh-uDYFhpsQDass.-Wlsplplspuph.sssshVtVphG.p..spshplhlhlp+EsGtWKIhcVpsss	...............................s.pQsV+phYpsY..hosh..........ssshhs-Tsp...........ct..hsStcl.ptLsLsssL........sshsh..lDhD...PhscsQDauc.hh...l.c.s.lslsp..scs.spu.cAsV.chpl.......h.....ps-cc+ps.....slp..hltE.s.GRWhIs-lsss.c.................................	0	6	14	28
+12724	PF12884	TORC_N		Transducer of regulated CREB activity, N terminus	Zenonos ZA, Mistry J	zz2	jackhmmer:Q6UUV7	Family	This family includes the N terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [2]. The proteins display a highly conserved predicted N-terminal coiled-coil domain and an invariant sequence matching a protein kinase A (PKA) phosphorylation consensus sequence (RKXS) [1]. The coiled-coil structure interacts with the bZIP domain of CREB [2]. This interaction may occur via ionic bonds because it is disrupted under high-salt conditions [3]. In addition to CREB-binding, the N-terminal region plays a role in the tetramer formation of TORCs [2], but the physiological function of the multimeric complex has not been clarified yet.	25.00	25.00	26.30	30.90	23.70	24.10	hmmbuild  --amino -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.42	0.72	-3.44	13	158	2010-03-17 15:32:13	2010-03-17 15:32:13	2	5	63	0	75	136	0	64.30	56	11.44	CHANGED	NPRKFSEKIALppQKQAEETAsFEcIM+-Vpuo+hspppspppp........................s..s.u.thhGGSLP	.NPRKFSEKIALHsQKQAEETAAFE-lMpDlssTRhpttplppsp...........................spu..paYGGSLP.........................................................	0	15	25	48
+12725	PF12885	TORC_M		Transducer of regulated CREB activity middle domain	Zenonos ZA, Mistry J	zz2	jackhmmer:Q6UUV7	Family	This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [1]. Although the C- and N- terminal domains of these proteins have been well characterised [1-2], no functional role has been assigned to the central region, yet.	21.90	21.90	22.50	24.70	21.30	18.60	hmmbuild  --amino -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.19	0.71	-4.45	10	208	2010-03-17 15:34:46	2010-03-17 15:34:46	2	7	51	0	92	168	0	147.20	52	26.60	CHANGED	RTNSDSALHQSshsPsPQDsFsG.GuQslpspch...lLho................sPstE-s..ph-KcpsKQhW-tKK..ss.ouRP+SC-VPGINIFPSPDQphosSlhPuAHNTGGSLPDLTNIQFPPPLPTPLDP-Ds.sasohSuusSousLssshTHLGIouuup	..................RTNSDSALHpSsMsPssQ-sasG..usps....hh...p+h........hh.s...................................sP..s..h.EEsh..ps-+sh.cQ.W-sKK...os.uSRP+.SC....E....V...PGI....NIFPSs-Qp.sss.sh.hPushNTGGSLPDLTNlHFPsPLPTPLDPE.-s...sas...uLS..uusSTu.NLssshTH..LGIuus..t.................................	0	11	20	40
+12726	PF12886	TORC_C		Transducer of regulated CREB activity, C terminus	Zenonos ZA, Mistry J	zz2	jackhmmer:Q6UUV7	Family	This family includes the C terminal region of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerisation domain of CREB (cAMP Response Element-Binding) [2]. The C terminus region is negatively charged, resembling the transcription activation domains. When this domain, from all three human TORC proteins, was expressed as fusion proteins with the DNA-binding domain of GAL4 (GAL4-BD), and tested for induction of a minimal promoter linked to GAL4-binding sites (UAS-GAL4), UAS-GAL4 was potently induced by GAL4-BD fusions containing the C-terminal portion of all three human TORCs [1].	21.50	21.50	21.50	22.10	20.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.59	0.72	-3.80	8	195	2010-03-17 15:36:07	2010-03-17 15:36:07	2	8	60	0	94	170	0	73.50	55	12.73	CHANGED	PNIILT...........sDSsP..uLSKDluuALAGVsshsaDu-s....FsL-DEL+..l-PLuLDGLpMLS.DPDhhLsDPAlEDSFRuDRL	.....................................PNIILT...........s-.SsP..uLSK.-lsuuLAGVs-hsh...s..s..-s....FsL-..D.EL+..l-PLoL.....DGLpMLs.DPs.h.lLsD.PulEDoFRtDRL....	0	13	21	43
+12727	PF12887	SICA_alpha		SICA extracellular alpha domain	Finn RD	rdf	Manual	Domain	The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies.  This domain is typically found at the N-terminus, with 1 or 2 copies per protein.  The domain is cysteine-rich domain  and similar to PFAM:PF12878 [1].	21.70	13.00	23.20	13.10	20.80	12.90	hmmbuild  --amino -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.20	0.71	-4.54	71	105	2012-10-01 20:19:39	2010-03-17 16:07:03	2	21	2	0	103	131	1	180.80	26	21.68	CHANGED	sssLhppWhpph........hpss...ut.s.spss.........ppIsscL.+cpLcctaccLp..shLp.p.sp.us........ElsshCus.............hsttt.s...ss..t..pp...ph.KplCKullcl+YFMuGlcsppp..........cp.tsthsthpshctYsRClVGtlALsclYG-HCclccllptlpsplc....pplpsp..tspss..........hspCp.s.lshp-lhhG+slLsspIcpW	................s.stlhptWhpph.tts.t.s.s............tplhpcl.+cpLcchaccLp..phLp..t.tpst.........ElsshCss...............hhttt.sst...t..pp....h.KplCKullcl+YahuGlcpptp............cp.tsthpshpshctYhR...ClVGtlA...Lscl..Y..G..-......H......Cclp.cllpplpsplc............pplptptspss..........hspCc..s.lshpcLhh.G+slLtspIcpW...............................................................................................	0	0	0	0
+12728	PF12888	Lipid_bd		Lipid-binding putative hydrolase	Coggill P	pcc	JCSG_target_393040_3h3i	Family	This is a small family of lipid-binding proteins found in Bacteroidetes.	21.50	21.50	21.50	31.70	21.30	19.50	hmmbuild  --amino -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.42	0.71	-4.25	5	26	2012-10-03 05:44:19	2010-03-17 17:49:49	2	1	23	3	6	26	1	114.50	33	67.72	CHANGED	lGAGalphsTYNTAANssTEMWL-D..huNhWssKlKVsVDYsuRTFouTG....lusplsuDsKVslT.....DGKVLcGAATTPSGMPADSIVahlpFsDDssGhTYKVuGFRRTGFPADD	......................................hstthphpTYNTsssssscMWlc............hsshas..h+sKlssDhsupoFssss....hsst....h.psDs...p..lslT.........................-GKVlhsuuTT..uGsssDSIha.hpFosss..GhTYplsGaR+TGastD-..........	0	3	6	6
+12729	PF12889	DUF3829		Protein of unknown function (DUF3829)	Coggill P	pcc	JCSG_target_393163_3iee	Family	This is a small family of proteins from several bacterial species, whose function is not known. It may, however, be related to the GvpL_GvpF family of proteins, Pfam:PF06386.	25.00	25.00	25.30	25.30	24.60	24.60	hmmbuild  --amino -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.78	0.70	-5.21	47	668	2010-03-17 18:27:44	2010-03-17 18:27:44	2	4	523	3	45	381	4	246.60	42	80.92	CHANGED	ssspthpKhNsYlp.hhNplt...tshhpshtpYhshhtchcpst.ptpphhh.sh.th.......cpshpthcps.......ht.psshtslDpss.....pshhsshpplh.shhschpsYappcsYpcDshs+ucpL...psplhtthppapsshpshpstlpchpccppttphpt........hcp.pscththtthphh....tpscpl...ht.h.ttpp.tthchtshp................ttlschpptlpshcphhtt.thpt.........thhpshspapssspphlpcl+s...................hh....tsshsphhpsYNphlsshNpht	...................................................tttshscKhssYIc.saNplp.......hsl.pulscYsch......hc..Dh+pGP.TGcEph..lhslhsl..........htpCpcthKps.......sALsPshpslDusA.....luYI-uAsALusTI.NEM-KYYsQ-NYKDDAFAKGKsL...HpohlKsl-sFcslucpYcsuIpchs-c+phspLKp........lE-.pE..GKohp....YYo.LslM.....loAKQI.....NslI.op-p...FDscAhh................KcluELEohls.....phKchspss......................uFlsS.AspYQhpsKKalRRlRDpV.......hpphpssss.uahs.........p-Sastsl+pYNEhVDsYNph............................................	0	13	26	38
+12730	PF12890	DHOase		Dihydro-orotase-like	Coggill P	pcc	JCSG_target_393237	Family	This is a small family of dihydro-orotase-like proteins from various bacteria.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  --amino -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.86	0.71	-4.51	4	46	2012-10-03 00:45:34	2010-03-17 18:34:02	2	1	46	0	6	1447	801	171.40	49	50.21	CHANGED	K+lllshlshLu..LsthuhpAQsLhsT...........TWsAYGloFpAP........................AulsVE-DoEE...........ualhssssaYlTlQhL-uEGhK+.u-LsptLKshAsDDpVTsQouVpsFELPQFaGs.L+G...sCEs-+ClYuhLLsKsuusGFYlSIlYocEs	................................................................................................KLlsPGLlDlHVHLREP.GsptKETIpoGohAA.................................A+GGaTTlsAM..PNT..p.P....sPDphEphp.ltpt....................IpcpuplpVLPauuI.T..V.c.psGpEhsDht..........................sLhchGAF.A.F..TDDGVGV.QsAuMMhcA.MK+AAcL.c.h.A.l.V.A.HC.ED..s..o.L.h.s.p.Gs...V.HE.G...c.hu...c..c..a....G.......L.pGI......PSlC...EoV...H...I.......A......RDl.L....L....A...E......A.A.uC.....H..........YHVCHlSTKp....................................	0	0	4	5
+12731	PF12891	Glyco_hydro_44		Glycoside hydrolase family 44	Coggill P, Bateman A	pcc	JCSG_target_393205	Domain	This is a family of bacterial glycoside hydrolases formerly known as cellulase family J, and now known as Cel44A. It is one of the major enzymatic components of the cellulosome of Clostridium thermocellum strain F1 and of many other Firmicutes.	25.10	24.70	25.10	24.80	24.90	24.50	hmmbuild  --amino -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.85	0.70	-4.86	27	92	2012-10-03 05:44:19	2010-03-18 13:56:41	2	21	82	14	41	96	9	206.30	32	25.61	CHANGED	NtsNuGsDWhaps............sphssPutssspahcpshttGs.hshlTlphhGYVutDs.s.s..hspstshPss+asp.......................lthspssshuhsPc.............hsss.lYhsEa......Vsalhs+..hGsu..sssGl+hYuLDNEPsLWss..............THsclHPpslohsElls+slphA+slKshDPsAplhGPs...taGasuYhshss...sss.......ss..scusap.al-aYLcph..+pspcssGhRLLDVLDlHaYPpup	........................................................................h.NsusDWh.ps................t.suthhpthhpp.sh.t.ss..shhTl.hhGaVutct.........ttshsss+att.......................hh.ttss.hs.sPs.............h.ss.hYhs-a.....lphlhpp.....hGtu....stsulpuYplDNEPs.LWsp..............TH.clHPsssThsElls+shshApAlKssDPsAplhGPu...taGatu..Yts.ts......t.t........sp.....p.sshp.alsaaLcph...+ptpptt.GhRLLDhhDlHaYPps...................	0	25	33	36
+12732	PF12892	FctA		T surface-antigen of pili	Coggill P	pcc	pdb_3gld	Repeat	The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages [1]. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonisation of human tissues [2].	22.30	12.50	22.30	12.50	22.20	12.40	hmmbuild  --amino -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.20	0.72	-3.18	46	1757	2012-10-02 19:08:27	2010-03-19 11:32:17	2	125	375	11	237	1642	91	84.80	22	26.02	CHANGED	YpYslpEp.p..ssh.sG..lsYDs.p.phplsVp.Vs-ssps.thhhs.thhhsh...pt.s.p..pt..sh.tFsNo.a.......sss...s.....Lplp..KplsGps.......cscpF..sFslphp	.................................................apYslpE......h......t....s......s.......su.....lsYDs...t..p.hpl.sVp..Vsc.......p......s..pG.....th.....h......s....h..sp........................tt.t..............tt...................tF.sNs.Y.........................sss....p............hphp.....K.l...pG...t...t.........tttp...a....pF.l...t...............................................................	1	65	125	164
+12733	PF12893	Lumazine_bd_2		Putative lumazine-binding	Coggill P	pcc	JCSG_target_391417	Family	This is a family of uncharacterised proteins. However, the family belongs to the NTF2-like superfamily of various enzymes, and some of the members of the family are putative dehydrogenases.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  --amino -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.59	0.71	-3.55	61	306	2012-10-03 02:27:24	2010-03-19 16:13:43	2	10	241	22	137	612	378	116.00	21	75.47	CHANGED	s-hpulpsslpp.Yh-Ghhpu.DsstLcpsFHscA...tlhsht.pup...hhthshcpa.hshlpsp......tssusshptpIhsl-lsG.ssAhs+lcsphh..sh............papDaLsLl+.h-GpWpIlsKsap	.............................................s.p.pslppslpp.Yh-u.h.....tpu..DsstlcpsFpssu.............th.hshp..psp.............lp..t...h...s.h.sp.a...hshlppt...........ts..tt....t...p..t.p........tpl......p..lcls..u..shAhsclphphh.....st..............................pa....s....Dh........h....s..Ll.K.h-GpWpIlsKha.................................................	0	49	89	114
+12734	PF12894	Apc4_WD40		Anaphase-promoting complex subunit 4 WD40 domain	Coggill P	pcc	manual	Domain	Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,	21.10	13.40	21.10	13.40	21.00	13.30	hmmbuild  --amino -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-8.08	0.72	-4.46	29	282	2012-10-05 17:30:43	2010-03-22 10:40:44	2	24	200	0	193	362	3	47.10	26	6.94	CHANGED	ph.p.ls-Kslssp........lp...hhsasPpMDLlAluoccsplhlaRL.NhQ+........l.......as	...........................hspp........lp...hhsasPp.hD.LlAlus.........p.cGp...lhlaRl..shp+........lh.......................	0	65	98	152
+12735	PF12895	Apc3		Anaphase-promoting complex, cyclosome, subunit 3	Coggill P	pcc	manual	Domain	Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1, 2]. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20 [3].	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  --amino -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.20	0.72	-3.85	111	1548	2012-10-11 20:01:03	2010-03-22 11:07:53	2	603	877	14	798	4682	1088	82.70	18	13.86	CHANGED	pptpacsAlFhu-+lhshss..........p...psh........ahh....Apshappspa....ppA.hpll..............tphtt.ps...htspY.....Lh.A..pshh.cLpc...ac-AlssLtps	...........................................................................t...tappAlh.hhc+h.hp.sst...................p.....pst....................................hhh........Apsa.app.spa.......pcA.hphhpp...................................hphps..pp.............ps.ta...................lh...u.......pshh..phpc....hc-Alphlp..h.....................................	0	291	477	677
+12736	PF12896	Apc4		Anaphase-promoting complex, cyclosome, subunit 4	Coggill P	pcc	manual	Domain	Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle.  the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism [3].	21.40	21.40	22.60	22.00	20.90	20.00	hmmbuild  --amino -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.18	0.70	-11.14	0.70	-5.03	36	264	2010-03-22 11:31:27	2010-03-22 11:31:27	2	10	228	0	186	273	1	197.50	24	26.91	CHANGED	pLphlthshshh.p..ttphlhplAppssplpsLlpYlppshpplppta..cshhphh....cchhsshtpt..pt................p.tsshs.sphhcllhoGhss..slc-aLh..spLuE+GhK+hp+ssssuapslpcllhppLlsAhERhhllLscLpGlu+ap.t...........ltl.sspplsch......lpsspslhhhsacllhplspEhctF......pt.FhpWlph.hlchhss-..sp	..........................................t...hh.hchphl.p..th.tlhtlApphsplpsLlpYlppshpphpptW......cshh..h......spplsphst...pt......................................................sspsslt.schhcLllhGpsss.tLpp.aLh.......spL.s-..........+GhK+hspulpsuapslpcLlhppL.s...u...hE.......phhhhLu........cLpGhupap.ph....p.........lGL.sss..tlpps...............................lpsssshhlhspcllhslspphppF.......ps.FhpWLhh..l.hhtpp....t.......................................................	0	59	98	150
+12737	PF12897	Aminotran_MocR		Alanine-glyoxylate amino-transferase	Coggill P	pcc	JCSG_target_390749_3ez1	Family	These proteins catalyse the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid [1]. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyse this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of aminotransferases acts as dimers in a head-to-tail configuration [2].	20.30	20.30	20.30	20.30	20.20	20.20	hmmbuild  --amino -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.33	0.70	-5.92	5	444	2012-10-02 18:26:03	2010-03-22 16:02:22	2	1	437	8	94	3944	814	413.70	53	97.54	CHANGED	MTssAhsDALspAcAAY-sFKARGLKLNMQRGQPADADFDLSNGLLolLGEsDsRh.DGoDLRNYPGGVAGLPSARALFApYLDVKuENVlVWNNSSLELQGhVLTFALLHGlRGSsGPW..lu-..KPKhIVTlPGYDRHFLLLETLGFELLTVDMQsDGPDlDAVERLAAsDASVKGILFVPTYSNPGGETISsEKARRLAulpAAAPDFTIFADDAYRVHHLhuEu-+DsPVNFVuLuRDAGHPDRAFVFASTSKITFAGAGLGFVASSEDNIuWLuKYLGAQSIGPNKVEQARHVKFLp-YcsGLEGLMRDHAcLIAPKFcAVsEsLcsELG-.GGcYATWToPRGGYFISLDTlDPVA-RVVcLA-cAGVSLTPAGATYPuGpDPHNRNIRLAPTRPPL-EVcTAMcGVAsCV+LAoEEYRAGp+	.............................................................................................................................................................................ho.--Lssh+pplppcYscLpA+sLsLDlTRGKPSscQL...DL.SssLL.s.l....s.s.s.s....hss...-G.s.D.s.RNY.GGhcGlPElRplFuElLG......ls.....s-plIAusNS...S.L.slMa.D.llsau.hla.Gsssut+....PW.......spp....tpV..KFLCP.VPGYD..R.H...FA.I.oE.ph..G...I...EMIs..V...P..M.s...p.....c.....G....P....D....h....D....h....V.....c....c........L.......V.......A..........t..........D......P.........s.....l........K.........G...................h......W.s........VPhY.uN.PsGsoYS--T.VR+Ls.p.M.....p.s..A.A.P.D..F..R..I..a..W..D.N.A.Y..........A..l...H...p.....L...........t....D.t............p.........s.......h............h............s.......l.....L....t........h....u..p.......c...A.....G.N......P.........s.....R...s..a....h..F..A..S.T..........S.K.I.T.F..A.....G...u..G..Vu..F..l..A..u......S...p.........s.......N.........l....s...........W...........a...h...p...a...h....u.h.c...o.I..G...P..D.K...l.N.Q...L...R..H...s.+.F.F....t.....D..s..-.....G....V....+...t.H...M...c...+..H...t...pI...L....A.P....KFt...h....V.h-.lL...-...c....+....L....u.....s.t...s..l...A....o.W..T.c.P.p..G..G..Y..F..I......S....L...D........V...h.......-....G.........T......A..p....R....l...V....u....L....A..K...-...A...G...lu...L..T.s..A...G...A..o.a..P.....Y...t...+...D....P...c...D...+..N..IRlA.PS...a.Ps.l.-ELcsAh-ul.u.s.CV.hLAAsE+LL...pt............................................................................................................................................................................................	0	32	71	88
+12738	PF12898	Stc1		Stc1 domain	Bateman A	agb	Jackhmmer:O94276	Domain	The domain contains 8 conserved cysteines that may bind to zinc. In S. pombe this protein acts as a protein linker which links the chromatin modifying CLRC complex to RNAi by tethering it to the RITS complex. The region is reported as a LIM domain here, but has a slightly different arrangement of its CxxC pairs from the Pfam LIM domain Pfam:PF00412, hence why it is not part of that family [1]. The tandem zinc-finger structure could mediate protein-protein interactions.	24.80	22.00	24.80	22.30	24.50	21.80	hmmbuild  --amino -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.53	0.72	-3.92	21	74	2010-03-22 17:08:22	2010-03-22 17:08:22	2	3	71	0	62	73	5	83.60	29	26.08	CHANGED	KC.tsC+Kh+spssFSp+QLcchp+shhsp..hpshsspshspCppCs..us.pssEL....................pCs.hCs+sKuL-tFSKsQR+c.-ss..+ChsClpt	....................cC.thstchpshstFSppQlcphppthhpp......thhstpshhtCppCs..up.pssEl..............................pCs.hCs.+s+sL-tFSKsQR+p.scss.........+ChsCsp........	0	16	33	49
+12739	PF12899	Glyco_hydro_100		Alkaline and neutral invertase	Coggill P	pcc	manual	Domain	This is a family of bacterial and plant alkaline and neutral invertases, EC:3.2.1.26, previously known as Invertase_neut Pfam:PF04853.	23.60	23.60	23.60	23.60	23.50	23.40	hmmbuild  --amino -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.66	0.70	-6.09	20	347	2012-10-03 02:33:51	2010-03-22 17:10:24	2	7	135	0	171	342	258	358.00	51	75.19	CHANGED	pAWc.lL-colVaYpGpPlGTlAAhDs.ss...csLNYsQlFlRDFVPSuLsFLlpG..csEIVRNFLhhTLpLQupc+plDsap.GpGlMPASFKVh....ctt.....cEhLhADFG-pAIGRVsPVDSuLWWIILLRAYs+sTGDhohucsP-sQpGl+LILcLCLsssF-haPTLLVsDGusMIDRRMGlaGaPLEIQuLFYuALRsAppLLp.ss.....pss.pp..hlppls........pRLpsLshHlRpYYWLDhp+LNpIYRaKTEEYGc.s.u.hNcFNIhP-SIP.sWLh-.WLPpcGGYLlGNluPuRhDFRFFuLGNhlAIlouLAotpQupAIhcLlEp+W-DLlGcMPhKICaPAlEscEWRIlTGsDPKNpPWSYHNGGSWPsLLWhhsAAslK.............sGRsp.lAc......+Alpl.AccRLs+DcWPEYYDG+sGRhlGKQARpaQTWoIuGaLlA+tLl-.sP	..........................................................................................................................................................AhchhcpulV.apGpslGTlAA.D..sp...p.LNYsp.lF.lRDFlPSulsaLhpG..c.-IV+NFLhhoLpLQ..................u.........hc+......................hD.ap.upGlhPASFKl.........p.....tp-hL.sDFGppAIGRVuPVDSuhWWIILLRAYsK.oG.....Dhsltcp.-sQpGh+hILpLCLsc.uFDhaPoLLssDGssMIDRRMG..........laGaPlEIQ.uLFa..AL+suh.phLt...p.....t.ts..pp...hlptls..................pRLpALoaHhRpYaWlDhpplNpI.Y........Ra+TEEYSp.s.A.hNKF.NlhP-p.IP.sW.l.hD.ahPpc..G.G..YhIGNlpPA+MDFRaFsLGNhhuI.lSSLuTscQ.spuIhcLlEt+Wp-L.l..up......M..PlK.I.....C...YPAl..E..s..c..E..W...+...Il...T...G...sDPKNT..WSYHNGGSWPs..L..LW....h..ssAslK.........................hGRsp.....lAc.......+....A....ltl...uEpRL.cD..p....W..P..EY.Y..Ds+pG+a..lGK.QuRhaQTWoIAGaLlu+hhLcsP......................	0	28	99	142
+12740	PF12900	Pyridox_ox_2		Pyridoxamine 5'-phosphate oxidase	Mistry J	jm14	jcsg_3fkh	Family	Pyridoxamine 5'-phosphate oxidase is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP).  This entry contains several pyridoxamine 5'-phosphate oxidases, and related proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  --amino -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.85	0.71	-4.36	153	1956	2012-10-02 11:35:36	2010-03-23 10:43:58	2	14	1393	22	640	2144	210	137.20	22	77.98	CHANGED	cppphhplLc.sshlu+luhss....s....st..PhllPssashs......ssp......lhh+.sus...uu..+hhpshp............t.....sshsstp....hDs...hshsps.........s.a.SVllpGp.uchl...p-spEctpshpthhpph.hPt....ap..thc.......tthtt..sthlclphsphou+t	............................pphhplLp..ps.p.h.s......+luhss....s........st........Phl..lPlsashp.................ssp....................lYh..H..sut.....su..+hhchlp...........................tt....ssh.shsp.....................h.cs........hh...spp.......................tht.a.p....SVl.spGp.sphl.................p..c..t.p....E.p..t..t...ulchl...hp..p....h...sPt.......hp...h..............tt.htt.....ssll.+lphpphou+....................................................................	0	204	440	569
+12741	PF12901	SUZ-C		SUZ-C motif	Bateman A, Aravind L	agb	Aravind L	Domain	The SUZ-C domain is a conserved motif found in one or more copies in several RNA-binding proteins. It is always found at the C-terminus of the protein and appear to be required for localization of the protein to specific subcellular structures. It was first characterized in the C.elegans protein Szy-20 which localizes to the centrosome. It is widely distributed in eukaryotes.	21.10	21.10	21.30	21.10	20.30	21.00	hmmbuild  --amino -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.64	0.72	-4.27	26	299	2010-03-24 10:52:53	2010-03-24 10:52:53	2	12	94	0	157	272	0	32.90	42	6.69	CHANGED	phpthshssups.p.sVlRpP+GPD..uop.GFphpR	....................tphphssuss...sVlRpP+GPD..sop.GFptpp...	1	27	41	91
+12742	PF12902	Ferritin-like		Ferritin-like	Coggill P	pcc	JCSG_target_390707_3hli	Domain	This is a family of bacterial ferritin-like substances that also includes a C-terminal domain of VioB, polyketide synthase enzymes, that make up one of the key components of the violacein biosynthesis pathway. Violacein is a purple-coloured, broad-spectrum antibacterial pigment.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  --amino -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.78	0.70	-4.75	38	153	2012-10-01 21:25:29	2010-03-24 11:50:23	2	10	120	2	80	218	6	215.90	25	39.49	CHANGED	LppAl.plEhuTlP.YLsAhYSl.csssstp................................stphltslshEEMlHhslssNlLsAlGus.....Ptlst.p.....hPsYPsp.LP..tht...........shphsLtshohsslp.pFhpIEpP-............................................................oIGpFY.psl............hcul...ppLstpht...stsh..........Gc....tcpls.p.a..............stlhsVssh.soAhpAlshIh-QGEGsstss...........-..........sc.uHYh+Fpclhp	...................................LptAlplEhuTlP.YLsAhaSl..psststp...........................................shphlpslshEEMlHhslsuNlLsAl....GGs.....Pplst.th.........hssYPss.LP..th.t..............................shp..lsLtthohttlp...hFht.I...EpPp......................................................................................................t...th.o.IGt.hY.psl............hpsh.......tth.tth.........th....................Gt..........tpp.hh..t..h...........................................................s..h...lp...sh.psshtulp.IhpQGEGss.ss.........................................t.uHa.pF.pl..h..............................................................................................................	1	40	50	67
+12743	PF12903	DUF3830		Protein of unknown function (DUF3830)	Coggill P	pcc	JCSG_target_392654_3kop	Family	This is a family of bacterial and archaeal proteins, the structure for one of whose members has been characterised. PDB:3kop from Swiss:A0JVT3 probably adopts a new hexameric form compared to previous structures. The putative active is near the domain interface. 3kop is most closely related, structurally to PDB:1zx8, where the potential active site is located near residues E51 and Y53 (conserved in 1zx8). Beyond the two residues above, the other residues are not conserved. Also the shape of the active site differs from that of 1zx8. PDB:1zx8 belongs to family DUF369. Pfam:PF04126, which is part of the cyclophilin-like clan.	21.30	21.30	21.30	21.90	21.00	20.60	hmmbuild  --amino -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.04	0.71	-4.82	13	130	2012-10-02 15:38:38	2010-03-24 14:34:14	2	1	126	6	52	135	16	142.90	36	93.05	CHANGED	lTL-KRGVossA+LLD-cAPcTCsAVW-uL..PhuGplaHuKYARNEIYsLlPsFs......sscPstENsTVTPIPGDlsaFsFps..lss.uaGYcssstststss.lsDLAlFYGRNNLLlNGDsGWVPGNVFATIsEGL-....chApACpDlWhsGspGEoLoasRA	.............plsttuhshhAchh--cAPpTstAhhchL...PhpsphhHs+auGptlas.Lss....as.......hts.GhENsTspP.sGDllaa.........................sG.ho-htIhhuhsshhhsuchG.lsGNhFhTI.s.-.Gh-....pltphspclhhcGAps.shp................................................................................	0	12	33	42
+12744	PF12904	Collagen_bind_2		Putative collagen-binding domain of a collagenase 	Coggill P	pcc	JCSG_target_393067_3kzs	Domain	This domain is likely to be the collagen-binding domain of a family of bacterial collagenase enzymes. It is the C-terminal part of the PDB:3kzs structure determined from Swiss:Q8A905 (information derived from TOPSAN).	21.70	21.70	22.30	21.80	21.40	21.30	hmmbuild  --amino -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.15	0.72	-4.20	12	120	2012-10-02 17:35:21	2010-03-24 14:49:05	2	4	80	4	53	113	4	92.40	34	19.50	CHANGED	lPDQSllstsNGcchc+hhATRGpD..YhhVY.sasG+shplchuKIuGcchcAhWasP+sGctphIGpFcN..sstsFpssut...pGsDWVLllcs	.....................PDpSlls.s...t..s......sp+.hs+hlAoRupD..YhhVY.shs.GcshplsLscl.uG......sp..t.sAhWasP+sGchp...h.....l..G...p.h.....s.....s.......s.ht......sFps.Pus...spGNDW.lLllp...	0	28	43	51
+12745	PF12905	Glyco_hydro_101		Endo-alpha-N-acetylgalactosaminidase	Coggill P	pcc	Jackhammer	Domain	Virulence of pathogenic organisms such as the Gram-positive Streptococcus pneumoniae is largely determined by the ability to degrade host glycoproteins and to metabolise the resultant carbohydrates. This family is the enzymatic region, EC:3.2.1.97, of the cell surface proteins that specifically cleave Gal-beta-1,3-GalNAc-alpha-Ser/Thr (T-antigen, galacto-N-biose), the core 1 type O-linked glycan common to mucin glycoproteins. This reaction is exemplified by the S. pneumoniae protein Swiss:B2DRU5, where Asp764 is the catalytic nucleophile-base and Glu796 the catalytic proton donor.	25.00	25.00	25.30	25.30	19.50	19.30	hmmbuild  --amino -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.58	0.70	-5.85	3	455	2012-10-03 05:44:19	2010-03-24 15:08:58	2	39	408	3	19	333	4	408.30	56	27.05	CHANGED	DsKlDWQDGAIAYRKIMp-PlGuE-VsNpVGYRIsMNFGSQAQNPFL+oLDsVKKluLsTDGLGQuVLLKGYuuEGHDSGHPDY.GDIGpRhGGsKDhNTLIccGKEYNApFGVHINAoETYPEAKtFssDhl....DsssuhGWGWLDQuYsINpctDLpSG..pRFKRL.DhLtscsPDLDFIYVDVWssNQ......WsS+QLu-cINDhGWRLuTEaGGuhEpaSTWQHWAuDhsYGG.p.KGINScIhRFIKNHQ+DSWluNaPcVGGsAD+PLLGGaphtsFEGWQoR+Da-ua..I-shFssNLPTKFLQHYpITpWoNsEulc.Ksshpp.......hEssLKDsSsssslslpRK........DshRpRVhTLNGNsIh-Gt.GDcpYLlPWs.cQshKssoA-SEKLYHWNspGGTTTWTLP-GWpussTVYVYELTDLGRTcVKEV	...........................DpKVDWQDuAIAaRs..IMN......N...PpGhEcVt-lsshRIshNFuSQApNPFLhTLDslK+IsLtTDGLGQtlL...L.KGYsuEGHDSuH.sY.us.IG+RhGGhcD......hcs......LIEc.u+KYsAchGIHVNAoEoYPEuK...aF.NE....cIL..............sss..Y..ph...GWsWL..D..QuhpI.Dt.uhDLupG.....cLhch..c.h.K.....+....h....u...........s..s.LD...aIYVDVWGNutp....suWso+hLA...KEINpp.GWRhuhEWupuhEYDSsapHWAADhsYG...G..........h.TNKGh.NSsIsRFIRNHQKDsWlsD...hts.....s.PLLGGhsh..c-FEGWpG+....oDYNuY......lsNlFs+sl.TKahQHaslopWEs...G..s.ss.......ssp.....................hpsplVsssss...c.Vs...Voct.................Pphp.RTlTLN....Gpsl..........cG...............................................uuYLhPWs................sssp.-.KhYYaNspsGuoTWoLPssWAt...opVaLYcLTDQG+sc.t..ph.................................................	0	9	12	17
+12746	PF12906	RINGv		RING-variant domain	Bateman A	agb	Bateman A	Domain	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  --amino -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-9.35	0.72	-3.92	26	1986	2012-10-03 15:03:13	2010-03-24 18:10:39	2	31	326	2	1289	1950	106	50.00	37	10.43	CHANGED	CRIChpstspss........slhpPCpCpGolphVHpsCLppWlsp........psspp.....CclC	....................CRICh...pp.spppp............................Lh.p.PCp.Cp...........GolcalHp........sC....LpcWlpp......................psspp...............CElC.............................	0	402	693	1007
+12747	PF12907	zf-met2		Zinc-binding	Coggill P	pcc	manual	Family	This is small family of metazoan zinc-binding proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  --amino -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.03	0.72	-3.99	13	251	2012-10-03 11:22:52	2010-03-24 18:12:56	2	6	164	0	171	237	2	36.30	39	40.41	CHANGED	slhCclChpTFhsTsststLpEHA-sKHPK..sshpsCFPph	.....hpCplC+...hphss.tp.....h+pHhEuKHPK..ss..................	1	59	101	143
+12749	PF12909	DUF3832		Protein of unknown function (DUF3832)	Coggill P	pcc	JCSG_target_391895_3k6q	Domain	This is a family of proteins from bacteria and archaea of unknwon function. The N-terminal part of the structure from Swiss:Q0AZ30 shows remote homology to the N-terminus of the bacterial toxin/antitoxin 'addiction module', and the C-terminus is distantly related to the TTHA1013/TTHA0281 superfamily.	21.80	21.80	22.40	22.30	21.50	21.20	hmmbuild  --amino -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.86	0.72	-3.92	12	47	2012-10-02 16:06:15	2010-03-26 16:28:33	2	2	38	4	18	50	1	91.30	29	62.79	CHANGED	L.pshphpsphht-csGpl.olslspl-..lhssusTh-pAhpcLl-sLh-YupDYhschphahp.uPNRppHaPYlh.................plhhps.sp-clppll	........hh..pshphssplhpEsDGol.olsLspl-..lhususoh--AhscLlcsLl-YAcDahs-hphahs.uPNR+cHhPYlh.................plhlpc.sc-plppll...........................	1	11	14	17
+12750	PF12910	RelB_N		Antitoxin of toxin-antitoxin stability system N-terminal	Coggill P	pcc	JCSG_target_391895_3k6q	Domain	This domain appears to be the N-terminus of the RelB antitoxin of toxin-antitoxin stability system or prevent-host death system. Together RelE toxin and the RelB antitoxin form a non-toxic complex.  Although toxin-antitoxin gene cassettes were first found in plasmids, it is clear that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria, and these toxin-antitoxin loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress [1,2].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.21	0.72	-4.60	97	364	2012-10-03 00:18:00	2010-03-26 17:37:23	2	5	297	4	132	2153	384	44.10	28	52.34	CHANGED	M......pslsho-ARspLppllDpsspscpsl...IsR.p..sppsslllSh-php	...............M...tphNhp-A+spLopLl.-ps.t.p.Gc.p.sl...I..s..+.t....scssshllshp.....................	0	38	80	111
+12751	PF12911	OppC_N		N-terminal TM domain of oligopeptide transport permease C	Coggill P	pcc	Pfam-B_1473 (release 24.0)	Domain	Oligopeptide permeases (Opp) have been identified in numerous gram-negative and -positive bacteria. These transport systems belong to the superfamily of highly conserved ATP-binding cassette transporters. Typically, Opp importers comprise a complex of five proteins. The oligopeptide-binding protein OppA is responsible for the capture of peptides from the external medium. Two integral highly hydrophobic membrane spanning proteins, OppB and OppC, form a channel through the membrane used for peptide translocation.  This N-terminal domain appears to be the first TM domain of the molecule [1].	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  --amino -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.74	0.72	-4.59	398	11398	2010-03-26 17:47:28	2010-03-26 17:47:28	2	16	3658	0	2635	7363	2094	54.70	23	17.25	CHANGED	shoh.hp..-sW..+Rh++NKhAlluLhlllllllhA.lhu.Phl..uP....a...................sp.s.hs.......ht...hsPu	.......................hp.....phh.......cphh...+...s+...hA.h.h.ulh.l.l...llll.l.hu...l...h...u...Phl........us........a........s.........st.s....hs............h.......sP....................................................	1	740	1563	2104
+12752	PF12912	N_NLPC_P60	N-term_NLPC_P60;	NLPC_P60 stabilising domain, N term	Coggill P	pcc	Pfam-B_845 (release 24.0)	Domain	This domain, at the N-terminus, appears to be the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b1, the third an SH3b2 and the last, the C-terminal region, the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).	21.90	21.90	22.00	22.00	21.30	21.50	hmmbuild  --amino -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.57	0.71	-4.02	25	228	2010-03-29 10:40:00	2010-03-29 11:40:00	2	6	225	2	40	175	4	120.00	31	26.33	CHANGED	hhhhlhsslLh..suCus+ss.s......................h.....tDlphhPQ-hpsYsps..........lhsttpptt.spcapp+aFuPWppspsphstp-lhhshpth...tpppu...YuENhp.hs.shhcshhpsAshcsa	.................................................................hahshhllhh..suCupKshs...............................................pslShLPQ.spshshs..............................sccYp+haF.......uPWcss.hh.....s.....hps.....ps......lFWs.ashh...........hssps.......Yh.Ntp.hshuaacphIpNAslpca............	0	14	33	38
+12753	PF12913	SH3_6		SH3 domain of the SH3b1 type	Coggill P	pcc	JCSG_target_405735_3m1u	Family	This domain appears to be an SH3 domain of the SH3b1-type, and is just C-terminal to an N-terminal domain that is probably the stabilising domain for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein. The next domain is an SH3b2 and the last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).	20.90	20.90	21.00	22.50	20.70	20.20	hmmbuild  --amino -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.41	0.72	-4.73	53	435	2012-10-02 18:48:24	2010-03-29 13:38:20	2	10	430	2	70	327	10	52.70	44	11.45	CHANGED	PhFtsPp.sGpGaPF.DhhQpSslhsGoPVhlsHhSpDt....sWhaVpos.hshGWlcu	.............hapsPp.tsEGhPF.DhhQpShLpsGTPVhlhHhS+Dp....cWtaVhos.sshGWVcS...	0	19	49	61
+12754	PF12914	SH3_7		SH3 domain of SH3b2 type	Coggill P	pcc	JCSG_target_405735_3m1u	Domain	This domain appears to be an SH3 domain of the SH3b2-type, and is the second SH3 domain to be found, downstream of an N-terminal domain that is probably the stabilising domain, for the structure from Swiss:Q72DN3, PDB:3m1u, which is a four-domain protein.  The last, the C-terminal region, is the catalytic domain of the cysteine-peptidase type, ie family NLPC_P60, Pfam:PF00877 (details derived from TOPSAN).	21.30	21.30	21.70	21.30	20.60	20.40	hmmbuild  --amino -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.72	0.72	-8.20	0.72	-4.19	41	382	2010-03-29 12:38:44	2010-03-29 13:38:44	2	5	381	2	47	261	5	49.80	32	10.79	CHANGED	scphlppapsh..p.ahsllp-psslh...-ppGpahhpu+lGslhPlhspstst	.........spchlp.atpL...p.hhs.lpsplsla....stsGsaaFpuRhGslhPhhcpcts........	0	12	30	39
+12755	PF12915	DUF3833		Protein of unknown function (DUF3833)	Mistry J	jm14	Pfam-B_259 (release 24.0)	Family	This is a family of uncharacterised proteins found in Proteobacteria.	25.00	25.00	25.50	25.40	20.80	19.70	hmmbuild  --amino -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.69	0.71	-5.01	105	426	2010-03-29 12:42:56	2010-03-29 13:42:56	2	1	405	0	121	374	1121	163.30	40	91.88	CHANGED	hhs.hhLsuC..uu..slsD.Ytsp.sPphcLcpaFsGclpAaGhlpchsGcVhRRFsVclsusW....c....GsphsLcEcFhYsDGp....pppRlWpLstsus....GpapGoAsDVlGpAp........GptsGs.AlpWpYslcLPl.....-usshpVshDDWMYLhc-ssllN+ophpKFGlcVGclsLshcK	.....................h.hhhLsuC....uu..pls-Y..psp.pPphDLtpaFsGphpAaGhlQDhoG+lsRRFpVslpGph....-....Gs..phsLs.EcFlasD..Gc....pppRlWplp....+t.u-......spYpGs....AsDllG...pAp........GptsGN.AlpWpYshpLsl.....-usshpVpFDDWMYhhD-pplhNcophpKFGlcVGclTLhFcK........	0	24	63	93
+12756	PF12916	DUF3834		Protein of unknown function (DUF3834)	Coggill P	pcc	JCSG_target_400673	Family	This family is likely to be related to solute-binding lipo-proteins.	20.80	20.80	20.80	21.10	20.60	20.30	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.34	0.71	-5.31	10	19	2012-10-03 15:33:52	2010-03-31 17:06:15	2	2	13	1	18	29	4	188.30	31	82.80	CHANGED	M...........+llsAP..GPVSYPLIAu.hhcpcDl-I..hFuK.cGpuDV..VLDShVSLsKp...Gl+Ishsll+cLhsIhPclup.+IulWRKGSAADlLsRsllDlpsh+uElVYu-D.ppllcMLscGclsoAllu.ushupGcsF.E-Lhpphsl.lPGSCGAhlpsp..-cFIsAYpcGI-hh+pcPEpsA-YIucpLPhphspcFIcsll+pscas	...................................................llsAP..GPVSYPlIsu..hcpcDlcl...FsK...pspuDl..lLD...ShssLsKh...Gl+lshss...lpcLhhlhPplsp.......+IuVWR.+GoAADlLhRhllchpshc.......u...El.VYs-D.tplhcMhppGclpoAV.....l........s...u.hpc..G.th.E-hhs........hPGuCGs.s.ps.....p....pthlssYpcGI-hh+pcPpssA-hluppL..Phhhspchltslhcpsph...........................................................................................	1	4	7	14
+12757	PF12917	HD_2	HD_1;	HD containing hydrolase-like enzyme 	Coggill P	pcc	JCSG_target_394139	Family	This is a family of bacterial and archaeal hydrolases.	21.70	21.70	21.70	21.80	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.47	0.70	-4.55	3	447	2012-10-01 20:28:14	2010-04-01 14:05:03	2	2	442	3	51	577	15	210.00	60	97.87	CHANGED	MGIHQYFQSLSDLENIYRCPGKFKYQEHSVAEHSYKVTSIAQFLGsVEEQAGNEVDWRALYEKALNHDYSELFIGDIKTPVKYATPELREMLSEVEESMT+NFIEREIPEcFQslYRahLKEGKDsTLEGKILAVSDKVDLLYESFGEIQKGNPENVFlEIYoEALATIYEFREMASs+YFLKEILPDMLAEKGIEKTELPQLTscIsScuL+.--	.........................................MGlHQYF.ppLSDhEplhRhPGcFKYhEHsVAAHSFKVTcIAQaLusV.E.....E.h...p...Gp.c.INW....K.uLYE.KALNHDauElF.hGDIKTP.VK.YAosEL+chhupVEEcMs.-sFIc.-...EIPtp..ap.-lY+p.R.L......p.....E....G....K.D..Do.L....E..G.....Q....I...L.SV..ADKID.LLYEoFGEIQKtNPE.plFhEIYc.S.L-TIhp.F.-.c.Ls..SVQ.FIppIlPEM.LsEs..F..hs+sc.LpchThsIlp......pcpt..................................................................................	0	16	27	42
+12758	PF12918	TcdB_N		TcdB toxin N-terminal helical domain	Bateman A	agb	Bateman A	Domain	This is a short helical bundle domain found associated with the catalytic domain of the TcdB toxin from C. difficile [1]. The function of this domain is unknown, but it may be involved in substrate recognition.	27.00	27.00	27.20	27.80	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-9.05	0.72	-3.90	20	211	2010-04-04 12:49:17	2010-04-04 13:49:17	2	17	131	14	9	218	0	60.70	39	3.43	CHANGED	scYsLhh-slcpc..l.slo-ppp.cphpplpclpctIspYpsh..pcKNS..ppGpsLLppQuplLppl	.s.p.sLh.-slhpt..l.sho-p.hsKhh.pIp-lpclhspYpth.....sKNS..RpGlcLLpcQu-LLctl......	0	3	3	6
+12759	PF12919	TcdA_TcdB		TcdA/TcdB catalytic glycosyltransferase domain	Bateman A	agb	Bateman A	Domain	This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein.	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.83	0.70	-12.84	0.70	-6.02	14	376	2012-10-03 05:28:31	2010-04-04 13:55:39	2	24	176	14	22	503	17	327.40	31	26.98	CHANGED	-KplHhlWIuGs.ss-sshsYIphahcs...sDYsahlWhDssAahssphspslhc.Ahstulpplccshs....sspcFhcch.clphch.................................................QcsFhNYshhps.pshs...D-hRhpYLppth.phsp-clppY.............l.cslschhupspscI+shc.h.phpctp.hphYppEhlhRWNhAAASD.lRlhhLKEhGGlYhDlDhhP.......uhsp-lhcsIpc.u...shh.-ssphccshs-ulh+htph..p.......hpshchspLsppspsplppllsphpphs..............clFpslsshhlp-h.s.....p.h.ppuhhssphlNshhlo+KsStssshlIpt.pptYp.Lpchhp...............................................................................................................................................................................................................................................................................................................................................................................................NshsspFhcolsshpshcp...hsh...p.hhhhuhhssYhpDuh...hPcAhSTLslSGPslhstshhchhp.ht..sc.hlhppth+..........................thsahpPpolhupsss.-cpSoWshsct+s	....................................................................................................................................................................................................................................................................lHhlWluGt...s-...pYhp.ahth.......pash.hahD.pAhhh.phpt.lhp.u.p.s.h.th.pt...................h..h..t...........................................................p.h.............D..hh.aL.p.h.th....p..tth.........................t....t...t......l..t.t........h.....................Y.......thh....R.h....N.hsuAoD.lRh.hLpphGGlYhDhD..hhP.........sht.pl.....h............................t......p.h..c.lhphh..........................t.p.s.l.tt...t.h.p.hhtphp................................................................................phF..ht....p........................hth.NthhhshtsS.h.phl..t.p.tY..l.t.ht................................................................................................................................................................................................................................................................................................................................................................................................p.......h.................................................................................................................................................t.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	4	13
+12760	PF12920	TcdA_TcdB_pore		TcdA/TcdB pore forming domain	Bateman A	agb	Bateman A	Family	This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region.	27.00	27.00	33.70	34.40	26.00	25.80	hmmbuild  -o /dev/null HMM SEED	663	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.01	0.70	-12.88	0.70	-6.61	18	84	2010-04-04 13:21:11	2010-04-04 14:21:11	2	19	42	0	12	90	0	620.80	33	30.49	CHANGED	hupchssAspcLppcppLsppWlslhsolccpspstYplpFlN..cssspopalpTp-ppFhcapcahpcph.sslspthhh..psGclhtc...tsls-spsVssLNAuFhIQoLIpa......p.suppts.ssLusALKlpsYlshsQhuhGslpDssclspLlppAhptphphhsTt.......hpsh........hupssspGlullhsGsslGhsIaELupAcsslp+shhuTpLuhsusuhssusuulshuhhuu............ussuulLGshuV.luGlulGlsuLspsauhluEcA+uVucYFsplspuhppsua..phpsppp...llhPhssuVlsplDhpsNplpasoptIaps....tpGpotsGphsaFF...........ssssh-cpp.ulsIppulGhsppphphsh.spupshlLPssPpp.hhpYEYshlPGspopcssGhclL...................................++lcpsp.p......F.acFYsFPu-a..sIspl+.cYhsTslclhLDpcsRpLlVPplsc-h.+s+LpYclpGsGGpYpLsLsst.splplss.......ss......psspWIIDsspl...cssoIp..pssplhlGslhhcl..shs.ppshlhhspp-Ip..........................pl-hsspphpl......llutctpphps...............sspslpp....+lppLuhsppLpsphsh......spsh.....ptptpshspsaaDssppchla...h.DssstpsptshhsslssshAahhststtslWtlD	..............................h.hcplssuhhcLpppppLs.cpah.sFpslpc..ss..p...taplpFIs..cpstcshaVpTccphFscatpalscpl.uplppphh...ssGclhtp...hslspsp.......tVssL.NAAFhIQoLIpa............suspts.ssLusAhKVpsYspLhphuhsslpDus+lVpLlpsAlppshsllsTh........pul.........................s..slusllsGl...slGhsIhELucspssl.+t.htspluh.usshssussulh...suu............hshuushuhhhVPLAGlusGl.suLlps.hhl.t-cAppVscY......Fsclshu.ppGsa.....ph.-.cp.......lhhP.sslVIocIDh....sss..p...lhhsp..ppIa+h....soGpTsosslsaFF...........susshshpp..tlsI........hssltlpppphsh.......sp......clhlLPssPpp.hhsaEhsh.hPGh..pohcssGhclL...................................cRlc-ph.c......FhacaauF.u-h......hIspL+.cY.-TsIcIpLDspsRphIlPhlsp-..........h...+pKLSYphhG...uG..GpYtlsLsph.hslslph.........s......csshWllDscpl.....cssoI....pssplphGsll.sl..pl...shpcstlllsppcIp..........................cVDhhs.p.phpl......llus-hphhh................sspplpp....+lshluhssclptshsh......spp......spppt.hspth.-ssh.phla...hpssp...t..hs.hu..hpshpshsh..hthhsuhahhD..............................................................................................................................................................	0	2	4	9
+12761	PF12921	ATP13		Mitochondrial ATPase expression	Wood V, Coggill P	pcc	Wood V, manual	Family	ATP13 is necessary for the expression of subunit 9 of mitochondrial ATPase. The protein has a basic amino terminal signal sequence that is cleaved upon import into mitochondria [1].	21.00	21.00	21.00	25.30	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.38	0.71	-4.78	14	101	2010-04-06 09:10:04	2010-04-06 10:10:04	2	3	99	0	74	100	0	128.60	24	20.08	CHANGED	spphhssllhuhua.GplphlcphlcplWsIsspsp.tt...........hstssshaPopclLhullsua.shspslpsAlpll-pF.cpYs.lcls....cphWccLhpWuthhhsh+tssttphhttshthhtph.pss	............sEphhsslhhuhu+tGplptl.cphl.c.plW.sIsssth.ppst...............ht.ssslaPos+lLhAlspuF.usN.scl.tAlpllDhluppYs..lsls....pphWpcLhpWoalhos.chs.t.ptp....t..........h.......................	0	11	33	62
+12762	PF12922	Cnd1_N		non-SMC mitotic condensation complex subunit 1, N-term	Wood V, Coggill P	pcc	Pfam-B_15091 (release 24.0)	Domain	The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis. This is the conserved N-terminus of the subunit 1.	21.50	21.50	23.10	22.60	21.20	20.50	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.85	0.71	-4.63	44	291	2010-04-06 09:13:56	2010-04-06 10:13:56	2	14	238	0	204	298	1	161.40	25	13.28	CHANGED	LssphppplhpLlsSulsshupplps.lpss.................-shspa+ptLEhYuaLlhhllphlp.......................t...ts..tt.hssttppppsspssstpWchs.splpphLpslsplLc.lcLs+lFhTos-+DpFls.LFoRsha.hlhEspth..hKspsl+hhlF+lluhuVK+Hupuhssp	......................................................thhpphh-hlhpslushuptlts.lpss..............p..........tsshspat..phLchhs.aLLthhlpshE.........................t.stps..sp...hstt......sp..ppptps....spspsa......chp.sphpthLphls...plLp...L............cLp.+l.atsos..c-pFls.LhTcssY.tlLE.s..ph......hKspsl+.tlh+lLshul++asHhhus....................	0	68	113	170
+12763	PF12923	RRP7		Ribosomal RNA-processing protein 7 (RRP7)	Mistry J, Wood V	jm14	Pfam-B_1057 (release 24.0)	Family	RRP7 is an essential protein in yeast that is involved in pre-rRNA processing and ribosome assembly [1].  It is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle [1-2].	27.00	27.00	31.00	29.20	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.93	0.71	-4.13	61	327	2010-04-06 11:06:40	2010-04-06 12:06:40	2	9	269	0	220	324	2	124.30	31	42.70	CHANGED	GhpcahppYcpp.hss..ptLppplcpahpta-...pccppppcpt.........tp.s.sDE.DGassVs+s..t+t.............sshspsp...htppttttptppc+c+Kphps..FY+FQhR...Ep++pclt-Lh+KFE-DKc+lpthKtpR.+F+Pa	........................................................ttahp.paptp..h.s......ptLppplcpaMpta-pcptpppcct.........ttp..shsDE.DG...alpVs+p...s+p..............................sshspst...........tspt.pht....tptpp.++..c+Kthts..FYpFQhR...Ep++pclspLh+KFEED+p+lp..hh+tpR.+F+Ph......................	0	71	119	181
+12764	PF12924	APP_Cu_bd		Copper-binding of amyloid precursor, CuBD	Coggill P	pcc	manual	Domain	This short domain, part of the extra-cellular N-terminus of the amyloid precursor protein, APP, can bind both copper and zinc, CuBD.  The structure of Cu2+-bound CuBD reveals that the metal ligands are His147, His151, Tyr168 and two water molecules, which are arranged in a square pyramidal geometry. The structure of Cu+-bound CuBD is almost identical to the Cu2+-bound structure except for the loss of one of the water ligands. The geometry of the site is unfavourable for Cu+, thus providing a mechanism by which CuBD could readily transfer Cu ions to other proteins.	26.40	26.40	28.10	28.10	24.80	26.30	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.24	0.72	-3.46	17	340	2010-04-07 17:32:00	2010-04-07 18:32:00	2	18	84	23	111	306	0	57.50	64	8.54	CHANGED	pCpF.Hhcph...shCpsapcW+ssApcsCps......cshpL+SauMLLPCG.lDhFpGVEaVCCPs	.............KC+FhHQERM...DhCEoHh......HWHTVAKEuCup......cuhsLHs.....YGMLL.......PCG.lD+FRGVEaVCCP......	0	20	27	61
+12765	PF12925	APP_E2		E2 domain of amyloid precursor protein	Coggill P	pcc	manual	Domain	The E2 domain is the largest of the conserved domains of the amyloid precursor protein. The structure of E2 consists of two coiled-coil sub-structures connected through a continuous helix, and bears an unexpected resemblance to the spectrin family of protein structures.E 2 can reversibly dimerise in solution, and the dimerisation occurs along the longest dimension of the molecule in an antiparallel orientation, which enables the N-terminal substructure of one monomer to pack against the C-terminal substructure of a second monomer. The high degree of conservation of residues at the putative dimer interface suggests that the E2 dimer observed in the crystal could be physiologically relevant. Heparin sulfate proteoglycans, the putative ligands for the precursor present in extracellular matrix, bind to E2 at a conserved and positively charged site near the dimer interface [1].	21.90	21.90	22.30	23.00	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.24	0.71	-4.73	11	385	2010-04-07 17:34:15	2010-04-07 18:34:15	2	22	91	16	118	340	1	175.40	59	27.13	CHANGED	sssssPsss.sul.DsYFppsssp........sEH..........ppFpcA+pcLEp+HRc+hscVMK-WpEAEcphcsL.+uD.......+pplhp+FQpplpoLEpEusuERppLlETHttRVtAhLN-+RRtAlEsYhsuLpssPPcs++lLpAL++YlRAEpKDRpHol+HacHlpps-P....E+Auph+splhpHLclI--RhNQSLsLLh	....................................h...sTsts.T..DsV.DhYhEsPuD-........NEH..........A+Fp+AKEpLEt+HRcRMspV..........M+EWEEAE...pQAK.NL.P.KAD.......+pslIQHFQph...VcuLEpEuAsE+Q.QLVETHhARV.EAhLNDRRRhAL.ENYlsALQ.u..s..PPRP++Vh.phL++YV......RAEp.KDRpHTL+HapHVhhVDP....cK.AAQh+s..QVh..THL+VI-ERhNQSLoLLY.............	0	21	30	66
+12767	PF12926	MOZART2		Mitotic-spindle organizing gamma-tubulin ring associated	Coggill P	pcc	[1]	Family	FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear [1].	23.30	23.30	23.90	30.60	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-10.09	0.72	-4.40	12	71	2010-04-08 11:58:30	2010-04-08 12:58:30	2	2	50	0	43	73	0	86.80	47	58.46	CHANGED	Mu...............................s.h.ph.hpptpsLss-Es..ELaELsphAGlslDs-VF+..........................lllDLl+hNVuPhAlhQhLKShCuupths.t......sssspusuh	....................ss..............s.........p....ushQKhul...++KKVLosEEh..ELaELuQAAGsslDP-VFK..........................ILVDLLKLNVAPLAVFQhLKSMCAGQRlusp......st-ssuhs.h.....................................	0	13	17	27
+12768	PF12927	DUF3835		Domain of unknown function (DUF3835)	Wood V, Coggill P	pcc	Pfam-B_14632 (release 24.0)	Domain	This is a C-terminal domain conserved in fungi.	21.00	7.90	23.20	8.20	20.60	7.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.90	0.72	-3.02	55	188	2010-04-13 08:34:32	2010-04-13 09:34:32	2	10	114	0	149	197	0	71.90	25	17.68	CHANGED	lluDtllE+s..............ssstchspphhpcpls.pahch+pthh.t.t.....................................pssPtKhSRFKuu..Rhs	................................................................................................lhcp.......................thp.thh.ppls.....pahch+pphlppps.t........tttpt.....................sl-c................psss.c+...lSRFKuuRh....	0	35	78	128
+12769	PF12928	tRNA_int_end_N2		tRNA-splicing endonuclease subunit sen54 N-term	Wood V, Coggill P	pcc	Pfam-B_644 (release 24.0)	Domain	This is an N-terminal family of archaeal and metazoan sen54 proteins that forms one of the tRNA-splicing endonuclease subunits.	21.10	21.10	21.10	21.40	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.29	0.72	-4.51	49	270	2012-10-01 20:02:48	2010-04-13 10:50:06	2	9	232	0	196	267	0	78.90	30	17.41	CHANGED	MassL.shsRhpph+shshuhap..s....................................................ppptspVsps+GpaapohG..............hs...pts+ha..LhsEEALYLlERGoLplhhss	..................................................phL.s..Rhp..p....p.shs...huh.ah..P...................................................................cpthspl..h.ps.+GpaapohG..............................hs........ppG+ha...LhPEEALYLlEpGolplha..s.....	0	58	101	158
+12770	PF12929	Mid1		Stretch-activated Ca2+-permeable channel component	Wood V, Coggill P	pcc	Pfam-B_1244 (release 24.0)	Domain	MID1 is a yeast Saccharomyces cerevisiae gene encoding a plasma membrane protein required for Ca2+ influx induced by the mating pheromone, alpha-factor. Mid1 protein plays a crucial role in supplying Ca2+ during the mating process. Mid1 is composed of 548-amino-acid residues with four hydrophobic regions named H1, H2, H3 and H4, and two cysteine-rich regions (C1 and C2) at the C-terminal. This family contains the H3, H4, C1 and C2 regions. suggesting that H1 is a signal sequence responsible for the alpha-factor-induced Mid1 delivery to the plasma membrane. The region from H1 to H3 is required for the localisation of Mid1 in the plasma and ER membranes. Trafficking of Mid1-GFP to the plasma membrane is dependent on the N-glycosylation of Mid1 and the transporter protein Sec12. This findings suggests that the trafficking of Mid1-GFP to the plasma membrane requires a Sec12-dependent pathway from the ER to the Golgi, and that Mid1 is recruited via a Sec6- and Sec7-independent pathway from the Golgi to the plasma membrane.	28.60	28.60	29.10	29.00	27.80	28.50	hmmbuild  --amino -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-13.04	0.70	-5.76	34	145	2010-04-13 13:17:33	2010-04-13 14:17:33	2	5	138	0	108	145	0	402.80	31	66.37	CHANGED	hhlalSsNhCppPs.........tssss.spLplYhS....hspss.tstssuphph....hcsGYhpshhp.sss................................slYIuVpu...............sssos................upasYclusSp.sshhapa-s..csalhhVDoDssuALLsTsNLTssstssts.pphht...............s.Yolasa..shs.cs.ths..uLppSaCAlpssspl.......hsstshps.......................ShTsRus......u....+pQFYlsGLNsSosYhuaLs..............stshsssGGtVapshpFsT+s.................sssCuLlasLsFCspVAYuVPusssh...............stspLsphYDshAtulYpNFohuLpQlsCsssscupYS.h+sCsDCssuYKsWLCAVoIPRCsshsss.salp..........................................tspssoRNshIschIpP.ssYhElLPCh-lCaslVRsCPushGFsCPs....s.hlstSYshcs...sss.hTCNYlGssh	..............................................................................................................................................thlalSuNhCtpPt...................t.stssspLplYhS............hpps....s.ts....ts....sp.sh......Fp.pGahth.hs..sss................................slYlultu...............sss.sp...................................................................................hsu.asaclusS..sshhaphcs.....pshlhhlDoDssuALL.TsslTss.s...st.........pph....s...............s.ashash....shp.ss.thp..GlppShCulpststl........htstshps................................................................uhTpRG........................s.....+pQFalsGLNsSosYhuhLs............pt.....tss.shsssGGtVapshpFpT+s........................sssCtllasLsFCspVAYuVPussph...............ststLuphYDshApshYtNFopuLpplsCsssspshYShspsCsDCtpAYKpWLCuVoIPRCs-h.sss....salt.............pt...........................................hspssoRNs.hI.s..phIpP..usYhElLPC.-lCaslVpsCP.ushGFsCPp....sthhp.SYshtt.....sss..oCsY.Gss.................................................................................	0	27	59	91
+12771	PF12930	DUF3836		Family of unknown function (DUF3836)	Finn RD	rdf	Manual	Family	Family of uncharacterised proteins found in Bacteroidales species. Test.	25.00	25.00	26.80	25.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.66	23	146	2010-04-13 15:35:07	2010-04-13 16:35:07	2	1	61	1	16	108	1	125.20	32	86.98	CHANGED	MKspslhKsllhsuhhhsoslsssAsu....p.ssaIYNpEppsGhlsucTlaKh-.G..phLppah+YsYpYD-psRlopKcAhKWNss+spWpshaplsYs.Yssp..-lsssYucWNp++psYshshppoVY.phDs	..................MKspshhKsll.h.sAhlhssshssssps....t.sshIaNp-.p.psshllupslY+h-..G....ptLspahKYsYpYD-ppRhspKcAhKWsuscppWts..hplsYs..Yssp...plshsYscWNsc+psashsschoVh.h.s.s............	0	2	14	16
+12772	PF12931	Sec16_C		Sec23-binding domain of Sec16	Wood V, Coggill P	pcc	Jackhammer:O14029	Domain	Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure [1].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.99	0.70	-4.67	37	648	2010-04-13 16:54:12	2010-04-13 17:54:12	2	27	269	2	424	664	2	240.20	24	17.51	CHANGED	plhshL.s....Gc+-+AlhhAlcpR.WuaAhllu......Ssls+sh....WppVlp-Fl+.c-h.p.suss.......h...p........LuslaplFuGNhcpul-E.Lsss..................s.t..hs.ts...............W+-sluhlLsN.....+ss.p....sp..pulhs...........lGcLLsphGphtAAHlCalhA...tssh........s.sts..h...h..s..ss...s...shh.hlG...........h.ps.cuhLho........ElYEauhol........ss...h.....s...hPHLhs....aKLhHAhsLA-hGhpscAppYCDsIuusLK.uts+pS........h.hph...pLh..ppLp....c.lusph....p....s...s....s...o...SWl....SKPsh-KV.Gpl.tpFspFluGD	......................................................................................................h.hpphLlhGph..c.pAlphshcpphaucAlllA...pth...spch...atp.shp....pahppp........t..................p................l.pslht.....lhusph...ps.h.ps...hs..................................................hts...........................................W+ppLAhl...lo.s.........tss..s........p.t...ps.l.ss...............LGc.pL...t...p...c.......G.........h...h...p...uAphCYl....h..A.....ts..sh...................t........h.....h...s...p..p......sphshlu.......................................ph.hs.....csl.hs.........................................E.hhEaspsl............ss.p.h....hlssh.s...hK.h...YAphL.A-hG.hhs..pAhpYhphl.t..h..............................................................................................................................................h...............................................................................................................	0	106	230	333
+12773	PF12932	Sec16		Vesicle coat trafficking protein Sec16 mid-region	Wood V, Coggill P	pcc	Jackhammer:O14029	Domain	Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway [1].	23.00	23.00	23.30	23.90	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.54	0.71	-4.14	58	342	2010-04-14 13:53:08	2010-04-14 14:53:08	2	8	218	2	231	328	0	110.60	28	6.82	CHANGED	stPlhpaGhGGpllsshP...s.................st.sshhpsssuplclpslpsllsssp.................thppFPGPLhst.................KoKKKDlhpWLpspIsthppt...............................stpcpc-chLLWclLclhlc.psGs	.............................ashhpFG.GGpllpshP..........................................s.stp.spsu..Vclcshcsllppst..t...................phpsF..PGPLhpt.................cs+KcDlhpahppphsphtps...............................phtcpcsphLLWplLhlLscpsG...........	0	52	104	174
+12774	PF12933	FTO_NTD		FTO catalytic domain	Bateman A	agb	Jackhmmer:Q9C0B1	Domain	This domain is the catalytic AlkB-like domain from the FTO protein [1]. This domain catalyses a demethylase activity with a preference for 3-methylthymidine.	27.00	10.00	27.20	15.80	26.00	9.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.79	0.70	-5.24	8	102	2012-10-10 13:59:34	2010-04-14 15:13:07	2	3	51	1	40	84	3	255.40	57	61.02	CHANGED	Ds-.FtpshpssYsGFllDsPssLPscLHc-VppAFcoht+cGpFh+DlVpsGsK.lohT.VSRsLlG-pGhTY+Y.cLRLFAhPWss--p.......................chttshcshpRLN-hLspcopphLcchsssph.ssshpupCE..........................aNVTLINhM-P.ptpspstLK-EshFGMGK...hSVSWHpDSuLp-pSTVAVYppost..cs-...............cssWpVAL+.uhDttT.......PuLtlPLcstssYYMhcDFNuTHcHAVLsGsos.RFSSTHRVAhs	...................Ds-.Fap.Wph+YsKLllRcusolPE-LHccVQcAFLTL+KHGChF+DLVR...IpGK..DlhTPVSRlLIGsPGCTYKYLNTRLFTVPWPscGsphKYsp........................................s-ItsACpshlKLNDYLphEolpALct.s....ht-p...ppss.s..s.t....thh.ts.............................tp-.hshpsRsuYNlTLLNaMDP...tpMsYLK-EPYFGMGK...MAVSWHHDE..NLV-RSsVAVYsYSCE...s.-tpspp.....................................................phcGRDPshWHVGhKluWDIET.....................PGLAlPL+QGDsYaMLDDLNtTHQHCVLAG.pP.RFSSTHRVA-C.......................................	0	8	11	20
+12775	PF12934	FTO_CTD		FTO C-terminal domain	Bateman A	agb	Jackhmmer:Q9C0B1	Domain	This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans.  The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure [1]. This domain is alpha helical with three helices that form a bundle [1].	27.00	27.00	31.20	31.10	18.20	23.30	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.23	0.71	-4.69	8	94	2010-04-14 14:20:04	2010-04-14 15:20:04	2	3	55	1	41	75	2	134.40	57	31.48	CHANGED	sTapYI+sRCppALpslsshpsps..........s.thpsh-ssslphhtElHpEVEFpWlR.FWlQGsRHAppHc.YWpptIAELspuWcpMEtshphlLsc.l+pusp.......os-ppscsasslLhsLpEpp-LRcEastRspusAatsLPsDQ+PsshP........taD-ss...PLPFDLcsVIspLcppp	.......................GTL-YIhpRCplALQNlps-scss..........shSLKShEsuVlKQsEEIHN..EVEFEWLRQFWFQGpRYpKCTD.WWspPMspLEthW+KMEthophlLpp.l+pct...........................................s.cppschhsslL..LptRppLRpEWttRppsphhptlP.pptP.shP........happ.pp...PLPhsLp.hl.tlpt..h..........................	0	7	10	20
+12776	PF12935	Sec16_N		Vesicle coat trafficking protein Sec16 N-terminus	Wood V, Coggill P	pcc	Jackhammer:O14029	Domain	Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region [1].	20.30	20.30	23.60	23.60	17.00	16.60	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-12.08	0.70	-4.50	14	66	2010-04-14 15:49:59	2010-04-14 16:49:59	2	2	59	0	47	69	0	218.80	25	12.80	CHANGED	sshWss...tussp-sstcFFsQlpoQTKPI.............ahPsE.sE....SRaEEGhPLlDpsst.........ssPs-pst.pssplDslFstDcs...............s-sutFFsphpps.s.p.tpsssplpRKsToQVLsShpsst..s...uPhS................sPsup..asphLs..ssstp..ptp..cs.S..--sLutp...E.....h.p...p...sE--..............LAtRWpAhL-sD..D.DLLl-D-h.t........t.tph.stss...stssttsls.....SPhsosp..s.spPhhts..sYTP..............H	.........................................t.....t....s...ptt..F.sp.psQshPh.....................................hs.E.s-....uRaEEuhPLlssspt...........shppst.ttstl-shFptDts...............s-pusFFsp.t.t......p.....pp..s.sshp+KsT.QVLsohphpp.....p.ushs...............ttst.sp.....p.sp.l....ststp...hp....p..p..t-phttt..........................tp...................sE--..............LAp.+....W.p....AhLts..D..D..DlLlDD-h......................ttp..stss.....ss.s..h.s.....p.hsspp..s...tPh.t.......YsP.........................................	1	6	15	32
+12777	PF12936	Kri1_C		KRI1-like family C-terminal	Wood V, Bateman A	pcc	Pfam-B_8372 (release 7.7)	Family	The yeast member of this family (Kri1p) is found to be required for 40S ribosome biogenesis in the nucleolus [1]. This is the C-terminal domain of the family.	25.00	25.00	37.90	37.70	20.90	19.70	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.13	0.72	-4.04	58	317	2010-04-14 16:07:41	2010-04-14 17:07:41	2	6	275	0	236	318	6	94.60	36	14.27	CHANGED	hccph-chl-EhapL-h--hl.........ssthssR........FKYRcVsPps.FGLosc-ILhA.DDppLNpaluLKKhAsYRscctch....+-p+chp++t+hcch++csh	.................p..cphEphl-c.hhpLDhE-ll........sc.hssR..............F+YRcVsPss.FGLosc-ILhA.DDcpLNpasuLKKhusYRscctch...........c-p+phpcKt..c.pph+cph.........................................................................................	0	84	133	196
+12778	PF12937	F-box-like		F-box-like	Wood V, Coggill P	pcc	Pfam-B_22368 (release 24.0)	Domain	This is an F-box-like family.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  --amino -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.40	0.72	-4.23	369	8154	2012-10-02 00:56:31	2010-04-14 17:42:23	2	360	366	19	5916	10186	51	47.30	25	8.94	CHANGED	hspLPsElllpIh.................s....h.....L.s..sp..-.........Lhp.s.u.....tVC+pWppls..tcs.tL.W+chhhp	.................................................tLPsE..l.l.h.p.Ih................................................................................................s.........a.......................L..s.....sp.......s..............................L.hp..s..u.................tVC...+p.Wp.pls....tss...l..Wpph...t...................	0	2058	3220	4628
+12779	PF12938	M_domain		M domain of GW182	Coggill P	pcc	Pfam-B_71410	Domain	\N	21.90	21.90	21.90	23.90	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.84	0.70	-4.55	11	119	2010-04-14 16:45:07	2010-04-14 17:45:07	2	12	69	0	70	104	0	239.10	38	16.86	CHANGED	sHsu.u.tsshussc..........asuGuu..suhsFspNs.....sshuusssssGsG..ssNssls...ulssh......caLs..ps..............ushss.usuGupssGuushsustss...t.s.....tpu.QPSspQlRhLVQQIQhAVpsGaLNsQILNQPLsPQTLhLLNQLLs.pIK.......................pLQtsQpsLpRttsu...........................pshplsltIsphKppIssLQNQIss......pQulalK....t.....t.....................t..hupuusshhtspsshssLpsph	..........................................................................................s.tts...t.sa..p...........uuhh...ttsssu..hsssshp......u..suhs.s.tth.thhst.thQs.........................................Ghhusuuuupupsh..p.p...ss..t...PsstslsusQPs.........hpupsPphh....S.ph.AQ.LQhAs+shtLNsuLLTpP.Is.PQphshLNQLhQ.Qls.......................+LQl..Q.QQhLQs.ptNsot.............................cppppQVuhsIsshpQQIQQhQpQlA........QALhhKQ............................p.shpssuu+SuhDsF....s.s+sphsuL.s...p..................................................	0	16	24	51
+12780	PF12939	DUF3837		Domain of unknown function (DUF3837)	Finn RD	rdf	JCSG_target_388609	Domain	A small, compact all-alpha helical domain of unknown function. This domain is currently only found in Clostridiales species. 	25.00	25.00	28.70	31.00	23.50	21.80	hmmbuild  --amino -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.31	0.72	-4.02	6	18	2010-04-22 13:29:43	2010-04-22 14:29:43	2	1	18	0	3	18	2	102.20	34	95.09	CHANGED	MlohIsKQAlslKsphp..AshsuNYEhYYAlGlhuKuhslshsctchs.hEL+-pL-pclct.p..PtDEp.phLhtlLpcac.sDDsaDtQMhELhpaGhpscp	MlopIA+QulhIKsp.hp.puslTuNYEhYYAsGlluKhhGlshs-......chpshELp-pLppclcphp..PpDEp-+hLhplLpsYc..s--shDpQMhELlpaGhp-p.........................................	0	1	3	3
+12781	PF12940	RAG1		Recombination-activation protein 1 (RAG1)	Mistry J	jm14	jackhmmer:Q6U1Q1	Family	This famiy contains recombination activating protein 1, which is the catalytic component of the RAG complex.  The RAG complex is a multi-protein complex that mediates DNA cleavage during V(D)J (variable-diversity-joining) recombination [2].  RAG1 mediates DNA-binding to the conseved recombination signal sequences (RSS) [3].  Many of the proteins in this family are fragments.	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.50	0.70	-6.13	3	12026	2010-04-22 13:54:52	2010-04-22 14:54:52	2	13	8629	0	36	11047	0	335.50	71	76.21	CHANGED	LLPGYHsFE........WpPPLKsVSsSTDVGIIDGLS.GhssSV-Easl.-sIu+RFRYDAALVSTLKDLEEDILEGhpcQGL--su.StlFTVVlKESCDGMGDVS.EKHGSGPhLPEKAhRFSFTIMsIoVK+cDGsslpVFEEsKPNSELCCKPLCLMlADESDHET.TAILGPllAEREAMKsScLhLEIGGloRsaRFIFRGTGYDEKLVR-VEGLEASGSsYICTLCDATRsEAuQNLVhHSITRoHoENL-RYEhWRoNPYNESsDELRDRVKGVSAKPFlETpPS...IDALHCDIGNAsEFhKIFQcEIGEVY+..NsNsTKEERK+WQotLDKpLRKKMNL+PlMRMNGNFARKLMTcETVEAVCELVpsEERREALRELlcLYlpM+PVWRuspPAKECPDLLCpYSa+SQRFAcLLST+FKYRY-GKITNYLHKTLAHVPEIIERE	...................................................LPGaH.FE........WpPsLKNVSsshpVGIIsGLS.Ghs.SlDDhPs.DTIs+RFRYDsALVsALKDhEE-IhEGh+tpsl-D.h....susFoVllKESCDGM.GDVS.EKHGuGPAVPEKAVRFSFTlMsIo.........l.....................h.......t.s..............p............-.............s.................l....p.............I.FpEsKPNSELsCKPLCLMhsDESDHETLTAILuPllAERcAMKpScLlLphGGl.RoF+FhFRGTGYDEKhVREhEGLEASGSsY...lCTL..........C.DuTRhEASQNhVhHSITRSHsENLERYElWRoNPapESsDELRDRVKGVSAKPFhET.Po...lDALHCDI....GNAsEFY+IFQ..EIGElYp.......pss...so+EER+pWpssLDKpLRKKhpLKPhMRMsGNaAR+LMotEsV-sVCELl.sEE.Rp.ALpcLMpLYlpMKPVWRuosPs+-CP-.lCpYSapSQpFA-lLuo.FpYRYtG+ls..................................	0	8	10	17
+12782	PF12941	HCV_NS5a_C	DUF3838;	HCV NS5a protein C-terminal region	Mistry J, Bateman A	jm14	jackhmmer:A1YSL9	Family	This is a family of proteins found in the hepatitis C virus. This family contains the C-terminal region of the NS5A protein.  CC The molecular function of the non-structural 5a protein is uncertain.  The NS5a protein is phosphorylated when expressed in mammalian cells.  It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, Swiss:P19525.	25.00	25.00	29.00	28.90	18.90	24.90	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.77	0.70	-4.80	17	15967	2010-04-22 15:12:44	2010-04-22 16:12:44	2	30	112	2	0	9643	0	185.50	77	38.13	CHANGED	SHITAEsApRRLuRGSPPSLASSSASQLSAPSLKATCTspssHPDAELIEANLLWRQEhGuNITRVESEsKVllLDSF-PLsAEh.DDRElSVuAECaRPsRPKFPPALPIWARPDYNPPLlEsWKtPDYcPPsVpGCALPPts.PPVPPP.RRK+sVpLDESsVSpALApLAcKoFspsssssct.SssGhsssosssssssstsDssSDssSaSSMPPLEGEPGDPDLSSGSWSTVSpE-D....VVCC	...................SHITAEsAtRRLARGS..PPSlASSSASQLSAPSLKAT....C.....TT...+....H....D....S.....P....DA....DLI.EA....N....L....L.....W....R....Q....E.M....GGNITRVESENKVVILDSFDPLpAEE.DE.RElSVPAEILRKSR.+FssAhPlWARPDYNPPLLEoWKcPDY.PPVVHGCPLPPspuPPlPPP.R+KR.TVVLTESTVSoALAELATKoFGSSpoSu..............hs.sssssss.......................................................................t.S.-.s.t.........................................................................................................................................	0	0	0	0
+12783	PF12942	Archaeal_AmoA		Archaeal ammonia monooxygenase subunit A (AmoA)	Mistry J, Finn RD	jm14	jackhmmer:A7U5N3	Family	This is an archeael family that contains ammonia monooxygenase subunit A.  Ammonia monooxygenase is an enzyme that oxidises ammonia to nitrite and nitrate, thus playing a significant role in the nitrogen cycle.  Ammonia-oxidising archaea (AOA) are widespread in marine environments [1].	25.00	25.00	33.70	33.50	20.80	18.20	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.03	0.71	-4.50	8	13679	2010-04-22 16:07:26	2010-04-22 17:07:26	2	1	283	0	2	13456	21	177.80	85	90.34	CHANGED	VAsNSTLhTINAGDYIFYTDW.....AWTSFVVFSISQShMLsVGAhYYhsFTGVPGTATYYAhIMTlYTWV...AKGAWFA.LGYPYcFllsPsWlPSAhLlcLuYWAT++NKHuhILlGGsLhGLSLPLF....NMVNLLhVpDPLEsAFKYPRPTLPPYMTPIEPQVGKFYNSPVALGAGAGAVLoVshAALG	..............VAVNSTLLTINAGDYIFYT.DW.....AWTSFVVFSISQohMLsVGA.....sYYL.hFTGVPGTATY.YAhIMTlYTWVAKGAWFA.LGYPYDFIVsPVWIP.SAMLLDLsYWA.T++NKHu.LILhGGsLVGhSLPLF....NMlNLlhVtDPLEsAFKYPRPTLPPYMTPIEPQVGKFYNSPVALGAGAGA..VLoVshAALG.................	0	1	1	2
+12784	PF12943	DUF3839		Protein of unknown function (DUF3839)	Mistry J, Finn RD	jm14	jackhmmer:A2DDZ9	Family	This is a family of uncharacterised proteins that are found in Trichomonas.	20.00	20.00	22.40	21.80	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.70	0.70	-5.21	3	2523	2010-04-23 10:20:04	2010-04-23 11:20:04	2	6	1	0	2523	2523	0	188.50	85	78.54	CHANGED	TTuPNSLVMNP.TSMLVEMKsFIPSSFTFETEIQKIKQELLTSsLDCoAKDETNEQYLYEMQDIIDHLPKLPEIQQQKLTIPEFDEItVKsTDSAEIKKFIRKVNsEFLGFHCNHKVMDKDCDMVYKNISDIYKSEEFKTYDNFVSLVAcCVWEIRDKDKRGKVWNEQIKPTsSELKKTIDALVVLAGQISMYNAKMNPQCSKCKAAIRKYNYSVKEIERMRNDYADLKKEAEKPAEDKMNML	....................TTuPNSLVMNP.TSMLVEMKsFIPSSYTFETcIQKIKQE.LLpusLDCoAKDEpNEpYLYEMQDlIDHLPKLPEIQQQKLTIPEFDEIEVKsTDSVEIKKFIRKVNYEFLGFHCNHKVMDKDCDMVYKNlSDIYKS.tEFKTYDNFVSLVAcCVWpIRDKDRRGKVWNEQI+PAhFEhK+sIDALVVLAGplS.YNAKMNPQ.C.SKCKAAhRKYNYSVKEIERMRNDYADLKKEAEKPAEsKMDML.................	1	2523	2523	2523
+12785	PF12944	DUF3840		Protein of unknown function (DUF3840)	Mistry J, Finn RD	jm14	jackhmmer:Q1H8S6	Family	This is a family of uncharacterised proteins found in hepatitis A viruses.	25.00	25.00	37.80	37.70	23.40	19.10	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.39	0.72	-4.18	2	2908	2010-04-26 15:16:45	2010-04-26 16:16:45	2	5	19	0	0	947	0	80.40	91	47.07	CHANGED	LSFSCYLSVTEQSEFYFPRAPLNSNAMLSTESMMSRIAAGDLESSVDDPRSEED+RFESHIEsRKPYKELRLEVGKQRLKYAQEELSNEVLPPPRKhKGlFSQA	....................FYFPRAPLNSNAMLSTESMMSRIAAGDLESSVDDPRSEEDRRFESHIECRKPYKELRLEVGKQRLKYAQEEL....................	0	0	0	0
+12786	PF12945	YcgR_2		Flagellar protein YcgR	Mistry J, Auchincloss A	jm14	jackhmmer:Q9KNC3	Family	This domain is found N terminal to Pfam:PF07238.  Proteins which contain YcgR domains are known to interact with the flagellar switch-complex proteins FliG and FliM.  This interaction results in a reduction of torque generation and induces CCW motor bias [3].  This family contains members not captured by Pfam:PF07317.	21.60	21.60	21.70	22.10	21.40	21.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.85	0.72	-4.10	119	585	2010-04-27 15:34:41	2010-04-27 16:34:41	2	3	451	5	179	481	9	88.40	21	37.67	CHANGED	lphGpplp.l....ph.....tss....ttt.....hp.opl..luhpps.thlhlshP.....hhsstthhlh..pGptlpl+hhspss....lhsFpoplhp..hh..ppPh.hl..hlshP	...................phGpclp.l....pl......psss........tpp.......hhhp..oplluh.....cps..thlllshP.....hpsspthhhp..pGhtlplchhssps......lhtFpoplhp..hh..pcPhshlhlphP...........	0	70	123	158
+12787	PF12946	EGF_MSP1_1		MSP1 EGF domain 1	Bateman A	agb	Jackhmmer:P04933	Domain	This EGF-like domain is found at the C-terminus of the malaria parasite MSP1 protein. MSP1 is the merozoite surface protein 1. This domain is part of the C-terminal fragment that is proteolytically processed from the the rest of the protein and is left attached to the surface of the invading parasite.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-8.15	0.72	-4.17	15	1331	2012-10-03 09:47:55	2010-05-02 12:25:03	2	13	39	10	19	696	0	36.90	71	6.05	CHANGED	sCls.sssPpNAGCFRassGpEEWRCLLGaKK..-usp..Cl	.......pClc..ppsP-NuuCaRaLDtpEEh+..CLLsaKp..EGsK..CV............	0	8	9	15
+12788	PF12947	EGF_3		EGF domain	Bateman A	agb	Jackhmmer:P04933	Domain	This family includes a variety of EGF-like domain homologues. This family includes the C-terminal domain of the malaria parasite MSP1 protein [1].	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.66	0.72	-3.99	174	4024	2012-10-03 09:47:55	2010-05-02 12:53:04	2	685	140	8	1803	4138	79	37.60	36	6.42	CHANGED	Ctssss..sCcspApCsNosG.......s.......asCsCp...sGapGDGhs.C	.............Ctps.s.s...sCc..s..s.A.pCp.pssu..........p.........................hsC.p.Cp......sGah..G..-.Gh.C...........	0	749	845	1435
+12789	PF12948	MSP7_C		MSP7-like protein C-terminal domain	Bateman A	agb	Jackhmmer:Q95VZ1	Domain	MSP7 is a protein family the malaria parasite that has been found to be associated with processed fragments from the MSP1 protein in a complex involved in red blood cell invasion.	27.00	27.00	28.70	33.70	21.00	25.80	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.71	0.71	-3.89	21	213	2010-05-02 13:01:12	2010-05-02 14:01:12	2	1	10	0	31	191	0	128.40	38	35.71	CHANGED	lKalDpLaD............................-lLss.pspKsplcsspa............+sKYNpF+ccY-...shNppEYcIlK+Llssahppsstss.ttsslh.......clFKKuLpDccapccF+NFlaGlYuFAK++NYLs......................sp+hps.pc.YpplFcNslsL	.................lKhlDcla-............................-VLpp..spcsclssspa............psKYs-FKKca-.F.slNppEY-IIKpLIhsFhpcsspspptpsclh.......plFhKsLcDcca+cpFKNalYGlYuaAKp.+sYLp..................................tc+hcs.cc.Y+plh-pshsL....	0	8	11	27
+12790	PF12949	HeH	SAP_2;	HeH/LEM domain	Mistry J, Sazer S, Wood V	jm14	Manual	Domain	This is a HeH domain.  HeH domains form helix-extended loop-helix (HeH) structures.\	      This domain is closely related to Pfam:PF03020 and Pfam:PF02037.	28.90	28.90	29.10	28.90	28.60	28.80	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.09	0.72	-7.38	0.72	-4.40	47	275	2012-10-03 03:04:30	2010-05-04 14:05:07	2	13	241	1	131	254	0	34.40	38	7.90	CHANGED	ssoLpVscLRplLsp+slpaPusAKKupLlpLhpc	.....psLTVscL+slLsppsl.sasusAKKu-LltLhp.......	0	35	72	115
+12791	PF12950	TaqI_C		TaqI-like C-terminal specificity domain	Bateman A	agb	Bateman A	Domain	This domain is found at the C-terminus of the TaqI protein and is involved in DNA-binding and substrate recognition.	27.60	27.60	27.60	27.70	27.50	27.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.61	0.71	-4.35	40	635	2012-10-02 00:09:28	2010-05-04 17:03:46	2	18	482	22	163	675	44	141.90	19	16.42	CHANGED	hslLpG.....cs.lp+Yplpas..................spYlsat.cthppsp...................................cchac...........p.KIll..Rplus.pls....usaDpcshhshsshhhlhhpstt..................lshchllulLNSclhp.aaapphh.p...tphh.+lphppLpplPl	.................................................................................h..hhcG......p.s..Ip+a.t.h.p.h.s.....................................t.al...h.h.....pthpptp.................................................................................................................tphac.................ptKIlh...tphss...cst.........FshD.s...p.....s...hhh.....p.......ss........sah..lh..tt...............................hs.h.ca.L.lu.lLNSclhp.aah..cph.htth....tssh..h..chptp.lp.plPl......................	0	70	132	152
+12792	PF12951	Autotrns_rpt		Autotransporter-associated beta strand repeat	Bateman A	agb	TIGRfams:TIGR02601	Repeat	This model represent a core 32-residue region of a class of bacterial protein repeat found in one to 30 copies per protein. Most proteins with a copy of this repeat have domains associated with membrane autotransporters (Pfam:PF03797). The repeats occur with a periodicity of 60 to 100 residues. A pattern of sequence conservation is that every second residue is well-conserved across most of the domain. These repeats as likely to have a beta-helical structure.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.49	0.72	-4.24	713	7020	2012-10-02 14:50:22	2010-05-12 12:53:43	2	164	932	0	1415	6703	697	31.50	41	9.95	CHANGED	uLsKsGsGTLs.L..o...G..sNT..YoGuTsl.suGoLplu	..................LsKsG.s.G.o..Ls.L...o............G....sNo..........Y.......o..G.s...T.....sl.s.u.G.oLtl................	0	364	771	1068
+12793	PF12952	DUF3841		Domain of unknown function (DUF3841)	Bateman A	agb	Jackhmmer:Q189I4	Domain	This presumed domain is around 190 amino acids in length. As yet no function has been given to any member of the family.	27.00	27.00	27.40	27.30	25.70	26.80	hmmbuild  --amino -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.31	0.71	-4.81	31	186	2010-05-13 13:05:00	2010-05-13 14:05:00	2	1	139	0	28	161	0	172.10	25	88.45	CHANGED	plaTtQscpshcplccsGhhhs+cE...Ylchchtp.u.hahpsYcWhlccupctl.shPpsscaPlWh..............uhpsctsh.p.ssssllLpLclPp-pllhh-hpcWshlLNhtYlspc-pDcttacchl....cphGltpphphh.o...thYPpl+pclpcSWcR.............................lF.........sttshs.ptlpuslWcl++E.Wlh	.................hlaThQsppshcplccpGhh.hsppc....alp............p.hhhuY..cWhV+ph.cp.+l...s.....pspaPIWsh...............ssppctsh...p...s.......pchVlLpLclPcchllhoshchWshhhspt.hhs...ppp..-ppthcchh....pp.th............hh.t........hsphh.phpcSac+................hF......................................t.tt.t.....ptlpus.Wp.++E.hl.................................................................	0	11	21	23
+12794	PF12953	DUF3842		Domain of unknown function (DUF3842)	Bateman A	agb	Jackhmmer:Q189S9	Domain	This short protein is found mainly in firmicute bacteria. It is functionally uncharacterised.	25.00	25.00	31.40	31.30	24.00	20.90	hmmbuild  --amino -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.54	0.71	-3.99	37	142	2010-05-13 13:13:52	2010-05-13 14:13:52	2	1	128	0	53	126	4	128.70	46	92.09	CHANGED	+IsVIDGQGGGIGppllcpl.+cphsc..l-IlALGTNuhATusMLKAGAscGATGENAllhsst+..ADlIlGPluIlhAsuhhGElTPtMApAlupStApKlLlPls.+ssh.ll...GspspPLscll-phlp.clp	.pIsVIDGQGGGIG+pllcpL.+cphsc.......lcIlALGTNulATusMLKAGAscGAoGENAllhsspc..sDlIlGPluIlhssuhhGElTPtMApAlupSpApKlLlPl.s.+ssh.ll...Gsp.stPLschlcphlp.l.t...	0	36	50	51
+12795	PF12954	DUF3843		Protein of unknown function (DUF3843)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1].	25.00	25.00	119.70	116.80	18.30	17.40	hmmbuild  -o /dev/null HMM SEED	387	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.32	0.70	-5.43	12	103	2010-05-17 00:57:42	2010-05-17 01:57:42	2	2	61	0	10	91	1	236.70	27	97.99	CHANGED	h+IYhKsWLplHshspshsTDpaYlshAN+lhslhcpo.Lh.shpt...pKplslhhAhYhEDsIushGhW+tFhptHppLYG+YLPFYshs-sYhsDEINhEDIpFlLWshhp..thht.tctsh.sPh-tslhchAphhYslh-cpaEpAP.s-phsphahs.sphhpt...........................................................................................hss..stpstpchscphcpFhpuopG+.LlYFssYc-LppFhlcsLpWpsccsphLPphppp+pFllaAss.KGlLlutslscYhsDccNPhYsucpAtppuachFs..hhCP.DLL+Yshp+slLPDAQhP......suKcll+cNWDFIARaaLtEY	............p.Whthp.h.t...sD.aahthAsplh.hh............l............thsl.hshahpDhlst.G.Wp.F...h.t.Ysp.LPFY..t....t............Yh.sElN.EDl.FllWth.p................P.s.s..thu..hathhpt.ap.AP.st..t..h...................................................................................................................................................................................................................................t...t.ht.hhthstst.hhahtt.tth..Fhhp..th..t....t..hst....tthhhhss..p.Gh..l...p.s.hhtp..Ns.Y...s.t.Attpuh..hhh....h.s..h...h.tpthls-h.h.........tpthhpp.hcFlsc.............................................................	0	2	8	10
+12796	PF12955	DUF3844		Domain of unknown function (DUF3844)	Bateman, Wood V	agb	Jackhmmer:O74728	Domain	This presumed domain is found in fungal species.  It contains 8 largely conserved cysteine residues. This domain is found in proteins that are thought to be found in the endoplasmic reticulum.	27.00	27.00	29.80	38.70	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.56	0.72	-3.92	32	106	2010-05-17 16:38:42	2010-05-17 17:38:42	2	1	104	0	83	109	0	102.90	41	23.96	CHANGED	CasSpcuCspuTssCSGHGpChcp.tst..............cCauCpCpsoh.pp..t......Koh.pWuGssCpK+DlSs.FaLlshsollllhhlsuuIthLaulGp-cLPuVluA	.CasSpcuCppuTssCS.GHGpChpp.tst..............tssCauCpCpsThspptt..t............+sspWuGssCpKcDlSs.FaLlssholsLlhhlshuIshLaulGpEcLPGVluA.....	0	25	47	72
+12797	PF12956	DUF3845		Domain of Unknown Function with PDB structure	Ellrott K	kellrott	JCSG structure PDB:3GF6	Family	Member PDB:3GF6 has statistically significant similarity  to TNF-like jelly roll fold may indicate an immunomodulatory  function[1] or a bioadhesion role[2]	25.00	25.00	479.30	479.10	17.60	15.20	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.56	0.70	-4.97	3	18	2010-05-17 17:26:20	2010-05-17 18:26:20	2	1	18	2	1	17	0	243.60	89	95.08	CHANGED	hIMNKIIGhAVLLLCLoGCVRDNDAIYYPVGNVDIERGGPALEVGpculLVARSYNEEDYVLDTLAQYPGDPTLGKLTFMINLKNQSuDQEVA-FNGVGKSKLTMSLGYKDGNYPVESQVPVYTSuDVTASYAIKLRLKGELTLTGDEWMIDYVYAQLAGLFQPYPPASFPEVFMCKGGEQsFuTFDSFRRTWTFDITYDRS-LSFSQLYFNLFVNLAGQKRE-RVRLRIDKESYFEIYKpKEEM	.hIMNKIIGLAVLLFCLSGCVRDNDAIYYPVGNVDVERGGPALEAG.KGDLIARSYNTEDYVLDTLAQYPGDPTLGKLTFMIsLKNQpADQEVsGFNGVG+SKLTMSLGYKDGNYPsESQVPVYTSSDVTASYAIKLRLKGELTLTGDEWMIDYlYAQLAGLFQPYPPTSFPEVFMCKGGEQsaATFDSFRRTWTFDITYDRSNLSFSQLYFNLFVNLAGQKRE-RVRLRIDKESYFEIYKEKEEM...	0	1	1	1
+12798	PF12957	DUF3846		Domain of unknown function (DUF3846)	Ellrott K, Bateman A	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain is found associated with an Pfam:PF07275 like domain. This suggests that this family may also be involved in evading host restriction.	24.60	24.60	24.80	24.60	24.30	24.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-10.11	0.72	-4.26	53	201	2010-05-17 20:05:53	2010-05-17 21:05:53	2	10	147	0	52	192	71	95.20	25	44.35	CHANGED	psLllpPsptsts.....hplsss...........LcslQphV......GG.IEslhh..........sc.s....sslhlN-EG+hpuLP.hNpthst...............tth.hhDhlsGshllsG...sspss.hs...sLssctl	...................................sLhlpPtp.s.h.....hpltss...........LcshQphV......GG.IEs.lhh.................pc.s....ssllsN-EGKhpGLP..lNcthts...................t...hh-hlsGshhlsG.....ppptp.hh..sLs.t................................................	0	30	42	50
+12799	PF12958	DUF3847		Protein of unknown function (DUF3847)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1].	40.00	39.00	40.30	40.10	39.70	38.90	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-9.91	0.72	-4.22	40	356	2010-05-17 20:46:12	2010-05-17 21:46:12	2	1	216	0	14	212	18	83.20	36	80.67	CHANGED	cp.LEpLppEhE+uEp+Lccsppc.KtLcpQhKpLp...............RKcRTHRLCTRGuhLEShl.csccLTD--lh.LLchIFppp-sp-hL+	...........................pph-cplcpt-cclKpLpNpp+pLcp....t....-....RKpRs+RLIp+GAlhESlhpE...sp-LTc-EhhpLlctl.t.......................	0	6	13	13
+12800	PF12959	DUF3848		Protein of unknown function (DUF3848)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain frequently seen with DUF3849.	30.00	30.00	30.00	35.10	26.40	29.10	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.39	0.72	-4.05	3	58	2010-05-17 21:43:24	2010-05-17 22:43:24	2	2	36	0	3	54	8	98.70	65	39.48	CHANGED	-LNTALYEKMoAEQ-KFRDWLKSQPPEEILNHAYEYTVREDIVMAMEELELTDAQAQALLDSPSPLADVYRYFEKVETDYMDsIRDCIEsRADDVCRAQcE	.........-LNTALYEKMAAEQDKa..RDWLKSQPPEEILpHsYEYTlREDIVMAMEEL.E.LTDuQApALL-SPSPLADVYRYFEKL.ETGYMDs.IRDSIEsRADDVCRApEE..............	0	2	3	3
+12801	PF12960	DUF3849		Protein of unknown function (DUF3849)	Ellrott K	kellrott	JCSG-Joint Centrer for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain frequently seen with DUF3848.	25.00	25.00	26.10	28.60	21.40	20.10	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.64	0.71	-4.21	8	86	2010-05-17 21:44:30	2010-05-17 22:44:30	2	8	49	0	8	81	12	131.00	42	25.96	CHANGED	PlYpHsAsYApE+sEL-tYRsSppsNhuCKEAIEsAIp-HYssNRLc.cuAVcpVlEpFGhERshaVLAsTlQpp-aDGRaSpsNK-WA+slshPss.ssh....sctshhhVssspPGLlDLFhcpsR+shtppQp	...............................................................PlY.aSAuYApEcGEl-pYRASppsNlpCKcu...IEtAIppcacs....pLs.csAs+sVlEpaGhERVpaVLANTlQpp.-aDG.RhSpcNK-WAKoIssssspsst....pths.ht.hh.ssspsGllDLFhcptR+phptpp.c.........	0	6	8	8
+12802	PF12961	DUF3850		Domain of Unknown Function with PDB structure (DUF3850)	Ellrott K	kellrott	JCSG structure PDB:3IUW	Family	The search results from NCBI sequence alignment indicates a conserved domain belonging to ASCH superfamily [1]. Dali searching results show that the protein is a structurally similar to the PUA domain, suggesting it may be involved in RNA recognition. It has been reported that the deletion of PUA genes results in impaired growth (RluD) and competitive disadvantage (TruB) in Escherichia coli.  Suggestions have been put forward that, apart from their usual catalytic role, certain PUS enzymes (e.g. TruB) may also act as chaperones for RNA folding. The interface interaction indicates that the biomolecule of protein NP_809782.1 should be a dimer.	30.00	29.00	32.20	37.80	29.20	26.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.37	0.72	-4.01	10	184	2012-10-02 17:37:24	2010-05-18 18:54:59	2	3	161	0	15	153	9	73.00	46	53.09	CHANGED	HsLKItPEaFpAVlEGpKsFEIRKNDRNaQVGDlLlLpEassG..pYTG+tspuEITYITD....YuQ.p-sYVVLSh+	......HcLKIhPcYFc..sVhpGpKpFElRKNDRsapVGDhLhL.......pE..a..p.p.G.............pYT.Gcp.......htscITa.l.T.D........asp...p-.....GYVlLulp......................................	0	2	8	12
+12803	PF12962	DUF3851		Protein of unknown function (DUF3851)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	23.00	23.00	210.20	210.10	22.40	21.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.62	0.71	-4.13	4	33	2010-05-18 21:24:42	2010-05-18 22:24:42	2	1	27	0	1	22	4	124.70	69	99.32	CHANGED	MKspILppcpMMFFDRAL-sQRotLLTsMADAVSECRTAADQAsELNEsGEsGLhRLsEIWsshhstcGhu..hllEGopsplLu-VVAQlYAYLotp.hhDPlGLAlYsELpaMMuSLMLGEWFE	MNPNILNpNPLMFFDRAVNAQRSQLLTVMADAVSECRTAADQAAELNETGQlGLLRLAElWSsIRAKEGMG.GLlLEGTEAKILSDVVAQFYAYLSGCMFNDPVGMAIYAELHYMMSSLMLGEWFE	0	0	1	1
+12804	PF12963	DUF3852		Protein of unknown function (DUF3852)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This domain frequently seen with DUF3848.	25.00	25.00	25.70	27.70	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.65	0.72	-4.02	10	46	2010-05-18 21:55:23	2010-05-18 22:55:23	2	1	31	0	11	44	3	106.80	63	97.58	CHANGED	KpKKhhhl.hlsVLlLshhFsssAYAuss.GDVAGAIEGTWpsASsQIKTVVNpVVFPAIDLILAVFFFuKLGTAYFDYRKHGQFEWAAPAILFACLVFTLTAPhYIWQILGM	...................KhK+hhhhlsllLlLshhFsssAaAAs.s.GDVAGAIEuTWssASsQIKTVVNpVVFPAIDLILAVFFFuKLGhAYFDYRKHGQFEWuAPAILFACLVFTLTAPhYIWpILGh..	0	9	11	11
+12805	PF12964	DUF3853		Protein of unknown function (DUF3853)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1].	22.10	22.10	22.10	22.50	21.90	21.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.19	0.72	-4.18	8	97	2012-10-04 14:01:12	2010-05-18 23:13:38	2	2	62	0	5	95	5	90.60	54	87.14	CHANGED	sLpcLLpKPVWpMTGEELlFLh++u....sppEscos.psspss-++aVYGIpGIARLFGCSlPTANRIKKSGKID+AITQIGRKIIVDA-LALELAs+c	.....................lppLLtKPlhQMTGEEhlFLtp+u......ppsc..sp.s.tssscs-++YVYGltGIA+LFGCSlPTANR....IKcS.GKID+AITQl.GRKIIVDA-LALELAG+K..............	0	2	5	5
+12806	PF12965	DUF3854		Domain of unknown function (DUF3854)	Ellrott K, Bateman A	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1]. This domain is likely to be related to the Toprim domain.	21.60	21.60	22.10	21.80	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.67	0.71	-4.50	54	235	2012-10-01 21:47:57	2010-05-18 23:31:30	2	15	148	0	78	233	13	113.00	26	15.36	CHANGED	FWpWVhpp.pIPlhITEGuKKAuuLLStGasAIuLPGIhsGYR..+cph....h.t.pL.lPpLthhApsGRclhlsFDp.DoKscThtsVppAlp+hGpLlpptGCpVpl..lpWs..t.tKGVDDhI........sspGtcsa	...............................................................................lhlsEG.hKs...th...h............p.........sh..slul......Gl.sh............t..................................l...hs.Lt...h.s.......s..+plhlsFDt..D...h.pp....ppVppAl.hchu....phL.pp.t.G.h..p..Vhl...........hs..Ws......s.sKGlDDhl........hst.....h.................................	1	16	59	75
+12807	PF12966	AtpR		N-ATPase, AtpR subunit 	Dibrova DV, Galperin MY, Mulkidjanian AY, Finn RD	rdf	[1]	Family	Membrane protein with three predicted transmembrane segments, two of which contain conserved Arg residues. AtpR genes are found in the N-ATPase (archaeal-type F1-Fo-ATPase) operons and are predicted to interact with the conserved Glu/Asp residues in the c subunits, regulating the assembly and/or function of the membrane-embedded ring of 'c' (proteolipid) subunits (PFAM:PF00137).	26.00	26.00	26.00	26.00	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.04	0.72	-3.84	38	110	2012-10-01 19:47:47	2010-05-19 14:12:51	2	1	103	0	51	134	7	85.70	30	84.35	CHANGED	hshhhulhsGhlLGhhaFuuLWhTl+phhsuppPshhhhhShLhRhulslushhh...l.....sssthttLLsshhGFlluRhlhlp......h...hpsp........t	...h..hhluhhhGhshGshaFsuLhhssR..........hhl..sup...sshhlhho.lhRlulslushhll.....upu..shttLlush.hGFhsARhlsl+hh...st............	0	16	35	44
+12808	PF12967	DUF3855		Domain of Unknown Function with PDB structure (DUF3855)	Ellrott K	kellrott	JCSG structure PDB:1O22	Family	Family based on orphan protein (TM0875) from Thermotoga maritima that has been structurally determined as PDB:1022. The TM0875 gene of Thermotoga maritima encodes a hypothetical protein NP_228683 [1] of unknown function. Analysis of TM0875 genomic context reveals the presence of MMT1 (a predicted Co/Zn/Cd cation transporter) and an inactive homolog of metal-dependent proteases. 1O22 shows weak structural similarity with the phosphoribosylformylglycinamidine synthase 1t4a (Dali Z-scr=4.6), the yggU protein (PDB structure:1n91; with DALI Z-scr=3), and with the thioesterase superfamily member (PDB structure 2cy9 - found using FATCAT), even though they have very low sequence identity.	27.00	27.00	307.40	307.20	25.10	23.00	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.04	0.71	-4.68	2	5	2010-05-19 16:59:37	2010-05-19 17:59:37	2	1	5	1	1	5	0	157.80	81	100.00	CHANGED	M+LMDSLEIhYh+KsK-htsLE+Kh+EIhpETGloL-sVNSE.hGRIFL+IsVLE-tEplPSFhlKALhPcpsAscLPLG-WssLp.VFVEEhsYL-sYs.MKIhS-tNhYTlYVPaSuVKpKNRsElVt-FMKYFFEoKGWsPGpYpF.VQElDslh	MRLMDILEILYYKKGKEFGILEKKMKEIFNETGVSLEPVNSELIGRIFLKISVLEEGEEVPSFAIKALTPKENAVDLPLGDWTDLKNVFVEEIDYLDSYGsMKILSEKNWYKIYVPYSSVKKKNRNELVEEFMKYFFESKGWNPGEYTFSVQEIDNLF	0	1	1	1
+12809	PF12968	DUF3856		Domain of Unknown Function (DUF3856)	Ellrott K	kellrott	JCSG structure PDB:2HR2	Domain	TPR-like protein. The 2hr2 structure belongs to the SCOP all alpha class, TPR-like superfamily, CT2138-like family. A DALI search gives hits with the putative peptidyl-prolyl isomerase 2fbn (Z=16), the SGTA protein (Z=16), the PLCR protein 2qfc (Z=16), a putative FK506-binding protein (PDB:1qz2-A; DALI Z-score 15.3; RMSD 2.9; 16% sequence identity within 132 superimposed residues), and with the tetratricopeptide repeats of the protein phosphatase 5 (PDB:2bug; DALI Z-score 15.1; RMSD 2.5; 19% sequence identity within 117 superimposed residues).	27.00	27.00	27.00	28.70	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.75	0.71	-4.37	10	11	2012-10-11 20:01:03	2010-05-20 00:48:56	2	1	11	6	10	16	0	144.00	56	82.41	CHANGED	KPL+EVAtAYhALS-AE+pLp-Gta-EAAtSsR+AM-hSRTIPsEEAFDHsGFDAhCHAuLSuAhutLGRY-EuLpSA-cAL+YFNRRGELpQDEGKLWIAAVFSRAlAL-ulGRp-EAlptFRhAGEMIAERKGEhsGKEpLh	....................KPL+EVAtAYhALS-Ap+pLpsGta-EAAtssR+AM-hSRTlPsEEAFDHsGFDAhCHAuLusAhutLGca-EuLpSA-cAL+YFNRRGELpQDEGKLWIuAVaSRAlAL-ulGRt-EAlttF+hAsEMIsERKGEhsGKEph.h....	0	1	1	7
+12810	PF12969	DUF3857		Domain of Unknown Function with PDB structure (DUF3857)	Ellrott K	kellrott	JCSG structure PDB:3KD4	Family	This family is based on the first domain of the PDB structure PDB:3KD4(residues 1-228). It is structurally similar to domains in other hydrolases, eg. M1 family aminopeptidase (3ebi, Z=10, rmsd 3.6A for 152 CA, seq id 12%), despite lack of any significant sequence similarity.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.74	0.71	-4.68	94	529	2010-05-20 21:30:11	2010-05-20 22:30:11	2	34	361	2	180	535	31	170.10	15	23.93	CHANGED	plp.ssGshph.thphshplhsppGlcph.uphpl..sa...ssphpp..lplhpuplhpssGp..h.clsss..t.hhphpt.tshtt.hasstpphh.lshsslpsGs.hlchpaph...............psps..shhsstasshhthpht............PstchphplphPsshslphpth....ts.stsp.pppsst.pha...paphcpl.shh..Es	...........................................................................................tst.s..hhphtlplhspsulcph..uphpl..........a........stphpp..........lplhpsps.hp...s..sGp...h..p..plsss...p..htshpt.t.st..stshasst.....ct....hs.l....shPslcsGs...h..lchp.aph...............ptpp...shh.sha..h.t.h.h..h...hp..t............PhtptphplphPtp..hslphphh.......s.st.p...p......tsst..phh..phphpph........t.............................................................	0	81	124	159
+12811	PF12970	DUF3858		Domain of Unknown Function with PDB structure (DUF3858)	Ellrott K	kellrott	JCSG structure PDB:3KD4	Family	This family is based on the third domain of the PDB structure 3KD4(residues 410-525).  It is structurally similar to part of neuropilin-2 (Z=4.6, rmsd 3.6A for 83 CA, 7% seq id).  This domain and the second domain appears to be part of peptide-n-glycanase (1x3w, 2g9f).	27.00	27.00	27.60	32.50	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.32	0.71	-10.45	0.71	-4.31	6	27	2010-05-20 21:56:00	2010-05-20 22:56:00	2	3	27	2	6	31	0	115.80	41	20.73	CHANGED	YthhsLPpA+sGhAuhs..hshlNocRssNLLLPtLsDEsYTYhVcssssMcssTssppKcIsNsVGplslTV+ppucchcVsRoL+LpKQhITPAEYssa+pLMoEWtDssspoLLF	...............YhlhsLPstcsGlus.t..hsthNScRosNLLLPuLs-EsaTYsVssspGMc.sTsshcKcIsNslGplslolpspusphcVhRoLcLpKQhITPu..-YssaRpLhsEWtsscspoLla..............	0	3	5	6
+12812	PF12971	NAGLU_N		Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain	Moxon SJ, Bateman A	agb	Pfam-B_6295 (release 7.7)	Domain	Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2]. The structure shows that the enzyme is composed of three domains.  This N-terminal domain has an alpha-beta fold [3].	25.00	25.00	27.20	25.40	23.40	23.70	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.93	0.72	-4.31	33	349	2010-05-23 13:20:51	2010-05-23 14:20:51	2	28	248	5	145	351	5	87.10	28	10.19	CHANGED	ptsuspsllpRllstcupp.Fphclhss.....stDtFpl..ss.......ssuc...lhlpGsssl...ulusGLpaYLKahC......tscloW..Gsp..lcL.....PpsLPhl	............................ssspsllpRllstpspp...Fphp....lhps.t.........spDhFpl.ss..............pss+...lhlpGsssl...ulAsG........LpaYLK.as......tsploW....s.usp..lpl.......PtsLP................	0	53	90	122
+12813	PF12972	NAGLU_C		Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain	Moxon SJ, Bateman A	agb	Pfam-B_6295 (release 7.7)	Domain	Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2]. The structure shows that the enzyme is composed of three domains.  This C-terminal domain has an all alpha helical fold [3].	25.00	25.00	27.20	26.60	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.04	0.70	-5.01	34	392	2010-05-23 13:23:40	2010-05-23 14:23:40	2	27	266	5	168	383	11	256.40	28	31.60	CHANGED	pWlppYucpRY.....Gt.pstplppAWphLhpolYssst.ssttps....pslhstRPsls.........................................spsphhYsspclhpAhclLlpsus....phpssssacaDLlDlsRQsLu.ptupphhhphhpAYppcDhtphpttuschl.pLlpshDcLLuocspFhLGpWlps.A+uhu...........ssstE..................+chYEaNARs.lThW.....uspGslh.DYAs+pWuGLlpsaYh.RWphahstlppslpts..............pshsttpa..thh.phEhtW.sp....sschass.....pstG-slphupp...lhp+h	.....................pWlppYsppRY......Gs...ts....tphtpAWplLhpolYssst.ttttps.......cslhstRPs.hs............................................tpsp.h.h.Ysssc.lhcAhclh.lpsss....phpss...ssacaDLlDlsRQsLu.phspthhpphh...puappp...............c......h..p.............t.h..ptt..upphl.cLl.shDplLuopppFhLGpWlpp.ARshu............s.stp-.........................cc..hYEhNARs.lThW........usp..G...s.lp..DYAs......+pWuGLl.......p.....cYYh.RW.phahstltpslpt.s..........................t.hsttp.a...thh.th.EptW..sp....sp.phass......psts.sslphupp.lh.....................................	0	58	102	140
+12814	PF12973	Cupin_7		ChrR Cupin-like domain	Bateman A	agb	JCSG target 403193	Domain	Members of this family are part of the cupin superfamily. This family includes the transcriptional activator ChrR.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.93	0.72	-4.14	88	1076	2012-10-10 13:59:34	2010-05-23 15:59:43	2	8	611	11	370	1097	835	89.10	27	55.05	CHANGED	sWhsSPhsGVpRt.Lc.Rhu.s.E.u.+sTolVRasPGopFssHsHsGGEEIhVL-GsFsDEp.GcY..PuGoYlRNPsGSpHsPa.S.cpG..CsIhVKLt	................................................hsGlthh.Lp....t.s..t...p.......tssLl+hs.s.G...s...p...h..s...p...H...p...H..tG..sEp.h.h.V.L..cG....s....F.....p....D.c.....p......G.....c....a.........ssG..salh.ps.s.s.s...p.H.s.P.h...s..p..p..G...slhh............................................	0	92	205	288
+12815	PF12974	Phosphonate-bd		ABC transporter, phosphonate, periplasmic substrate-binding protein 	Bateman A	agb	JCSG target 416811	Family	This is a family of periplasmic proteins which are part of the transport system for alkylphosphonate uptake.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.33	0.70	-4.99	178	3450	2012-10-03 15:33:52	2010-05-23 16:08:34	2	64	2087	10	931	7437	1283	236.80	20	68.71	CHANGED	hullPt.p.sssphhpp.....apslhshL...scpl......G.h...p...lchhssssasshhpsht.sGplDluahs.sh..shlh..h..p..pp.s.s..h.pslsph............ht......pG...p...s.........s...................apul..llspp.-.u..s..l...............................p.......sl............................p..DL.......cGcpluhssssSsoGhlhPthhL..............pp...t.G.l...........s.....p...........p.......h........h.p................h.h..a...s....u..sH-ssh.h.uVh.pGpsDuus.................sts............t............sh..pphh...................pps.....h...............ppl+l...........l...........h...........p.o.s...h.Pst.......s.lss.p.ss....ls....sp....h....ppplppsllshs..p.s................................sps.pphlpsh....s...h.....s...uFhsss.spsY	............................................................................................................................................................................hhs.p..s.tp.h.tp.....hp.s.hhph..l....p.cpl...........G..h......p....lp.h..h.h....s..s.s..a....s...s.h......h...p.u..ht...ts.p....l.D....l..u......h..h...s......s...h....s.h.s..........s....t......pp...s...s.......s...ps.l...spt............................ht........ts.....p.....s.............s..................................................a..p...S...h......l..l...sp.p....-....S....s...l......................................p............sl............................p...DL.........+G.+...p...h..u..h...s.s...s.s.Ssu...G..a..lh.Pt.h.h..L.........................................t.c...t..G...l........................s....sp.................................................p.........................h..p........................................................t.s...h..........s....u...u.....H......-.......s....s.l..h.s.lh.s.Gp........s........D.......s..us...........................................ss.s...........................................s....s.h..pp.ht...........................................................pp.t....h...................pcl.+.l...........l................................................h.................................p..o.....s.......h.....h.....P.s.........................s...h.s.s...p...ts.......l..s.............tp........h........tp..plpp..sh.hshst..s.......................................pt.tth.h.p.h.....t...h......t...th...p..........................................................................................................................................................................................................	0	290	614	788
+12816	PF12975	DUF3859		Domain of unknown function (DUF3859)	Bateman A	agb	JCSG target 416836	Domain	This short domain is functionally uncharacterised.	21.00	21.00	21.00	21.80	20.90	20.10	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.61	0.71	-4.46	33	110	2010-05-23 15:32:20	2010-05-23 16:32:20	2	7	98	2	33	109	13	130.10	29	51.56	CHANGED	hsthpshlshhpaGIasphsscspphsp..................hpptTphVPAclslpFGhhh.slpcucspp...............lphplhHPtI...hsspGpshpsasuplaspss-hshahh-ph..acsls......GpWph.plthcscllA-KoFpV	............................h.p.hlshhpaGlasphspc.p.h.p..................hhp.TspVPAclshcFGhhh..slp+s.cGpp..................lphhhhHPsl.....spcGphhpsapsplhssssDhthYhhsp...a-sls........GcWRh.tlhhs.scllA-KoFpV...	0	5	14	24
+12817	PF12976	DUF3860		Domain of Unknown Function with PDB structure (DUF3860)	Ellrott K	kellrott	JCSG structure PDB:2OD5	Family	A protein family created to cover PDB:2OD5. 2OD5 is a hypothetical protein (JCVI_PEP_1096688149193) from an environmental metagenome (unidentified marine microbe).	27.00	27.00	32.50	138.50	21.90	19.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.98	0.72	-4.19	2	2	2010-05-25 22:37:37	2010-05-25 23:37:37	2	1	1	0	0	5	106	88.00	26	100.00	CHANGED	McoppLRphI+paLsER..tNThEI.talsppMc.sosPpplsNlLptDcsIl+luTs++uGhh.sch.Is.Ws....lR....sta.-tcp.	McoppLRphI+paLsER..tNThEI.talsppMc.sosPpplsNlLptDcsIl+luTs++uGhh.sch.Is.Ws....lR....sta.-tcp.	0	0	0	0
+12818	PF12977	DUF3861		Domain of Unknown Function with PDB structure (DUF3861)	Ellrott K	kellrott	JCSG structure PDB:3CJL	Family	The 3cjl structure is likely a representative of a new fold with some resemblance to 3-helical bundle folds such as the serum albumin-like fold of SCOP. No significant hits reported by a Dali search. This protein is the first structural representative of a small (about 60 proteins) family of proteins that are found among proteo- and enterobacteria (REF http://www.topsan.org/Proteins/JCSG/3CJL).	27.00	27.00	30.10	30.40	24.00	20.30	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.99	0.72	-3.88	13	132	2010-05-27 00:12:12	2010-05-27 01:12:12	2	1	130	2	37	96	3	95.10	40	92.80	CHANGED	pppYRITlEpLsstpspstc...sLpFEhpsHDDlFsIVE+lKp+psh-..sppuspFuVGLKLhGEVMhpsRKHPLFt-FtPpFtsFMpsLKsts........p	............a+YRITlp.LpctcGcshsps.slpFEspNHDDIhpIlE+Lcs+csls..p-posuFuVGLKLFoElMhcsRc..HP..LFpshtstFppFMppLKpts.sp......	0	6	20	28
+12819	PF12978	DUF3862		Domain of Unknown Function with PDB structure (DUF3862)	Ellrott K	kellrott	JCSG structure PDB:3D4E	Family	PDB:3D4E shared structural similarity to beta-lactamase inhibitory proteins (BLIP) which already include 1XXM, 1S0W, 1JTG, 2G2U, 2G2W, 2B5R, and 3due. All of structures are involved in beta-lactamase inhibitor complex.  (REF http://www.topsan.org/Proteins/JCSG/3d4e)	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.76	0.71	-4.59	9	255	2012-10-01 23:09:26	2010-05-27 22:46:43	2	2	218	1	31	175	0	130.40	26	74.29	CHANGED	ppp-lRtpF-KIKlushpspFcGGoSl--LcplFG.cPspppppsAGsVpLcsYTWshDsVolslp.LhpNSolsKoIoNFpFs.RD.ploLK-YsslpcGhoYc-VschLGEPDshSpAsSS-cpplQAlWlSGlKuc.spuusloLsFENstLosKoQssL	.....................................................t........................p..usp.tplhthhG.p.tpp..........t..........W............s.t........s.....h.h..h.pst..s.....h.pt..s..h...t......+ptp..lshp.passl.........ppGh.oY..ccVpchlG.-P.-..s.h..spssh...s..s.ppphph.lahpshpus....sushsloF.pssplpsKsQ.sL.............................	0	10	20	27
+12820	PF12979	DUF3863		Domain of Unknown Function with PDB structure (DUF3863)	Ellrott K	kellrott	JCSG structure PDB:3LM3	Domain	Domain based on 1-364 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.	27.00	27.00	27.80	198.70	26.60	25.10	hmmbuild  -o /dev/null HMM SEED	352	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.12	0.70	-5.85	3	9	2010-05-27 23:42:17	2010-05-28 00:42:17	2	2	9	1	4	10	0	350.70	77	74.19	CHANGED	oslTL-GNRFVTLCIMIRTTPWEVSRDVKLHPRDEsSWHTLEGVRALREAFAKNNP-GRLTWGFTLNALEDpR-NY+QIR-YVVECQKKYGDEVSYFPGYFPAMYLPRERVNREMSEAIQLISKMVGNGYRPQSIMGGFLSADNLRYLAEKENIHVAHAVIWSQHNIDGGGADGSPSYPFYPSTEHFCKPAQGKSDFIDCVNLDGWTMDFICARRSGAMGHGIEGYNSRRGVGPIETYTGWGLDLGpREVMHTQAIHFDKGlELNGFGWVTNIWEAQMVHEFGQEFICKAMETWVTETKERWPDT+FVTFGEFGMLWRcpHKoN-DWNYRFVERGSGLGDSYNNLEIKWFMN	..EsLTl-GNRFVTLCIMIRTTPWEVSRDVKLHPRDEssWHTLEGVRALREAFAoNNPNGRLTWGFThNALEDGRcNYR-IRDYVVECQKKYGDEVTYFPG.YFPAMYLPRERVNREMSEAI-IISKMVGNGYRP.QSIMGGFLSADNLRYLAEKENIHVAHAVIWSQHNIDGGGADGSPSYPFYPSTEHFCKPAQGKSDFIDCVNLDGWTMDFICARRSGtoGHGI-GYNSRRGVGPIETY+GWGLDLGHREVMHTpAIHF.DKGlELNGFGWVsNIWEAQMV.HEFGKD.LICDAMchWVTGTKERWPDTHFVTFGEFG-LWRcQaKoN-DWNYRFVERGSGLGDSYNNLEIKWFMN.	0	1	4	4
+12821	PF12980	DUF3864		Domain of Unknown Function with PDB structure (DUF3864)	Ellrott K	kellrott	JCSG structure PDB:3LM3	Domain	Domain based on 366-449 domain of PDB:3LM3 which is encoded by the BDI_3119 gene from Parabacteroides distasonis atcc 8503.	27.00	27.00	106.30	105.40	25.20	24.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.62	0.72	-3.78	3	8	2010-05-27 23:42:58	2010-05-28 00:42:58	2	1	8	1	3	9	0	81.60	80	17.10	CHANGED	RLALLRDWHpKNAPAYVIDFTRYDLKA+EPADPSPcKPAKDWSLINVINQKGLRPQDKPVLLscL-sEcQ-LIRKYYPELFK	RLALLRDWHTKNSPAYVIDFTRYDL.AHEPADPSPpKPAKDWSLINKINQKGLRPQDKPVLIDKLEKEDQDLIRKYYPELFK.	0	1	3	3
+12822	PF12981	DUF3865		Domain of Unknown Function with PDB structure (DUF3865)	Ellrott K	kellrott	JCSG structure PDB:3B5P	Family	Family based of PDB:3B5P encoded by ZP_00108531 from nitrogen-fixing cyanobacterium Nostoc punctiforme pcc 73102 is a CADD-like protein of unknown function. Superposition between protein structures encoded by CT610 from Chlamydia trachomatis (PDB code 1rwc), pyrroloquinolinquinone synthase C (PqqC, PDB code 1otv) and ZP_00108531 revealed that putative active sites in CT610 and ZP_00108531 are identical. ( REF: http://www.topsan.org/Proteins/JCSG/3B5P).	31.60	30.90	31.60	30.90	28.60	27.20	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.70	0.70	-4.57	3	20	2012-10-02 21:56:19	2010-05-28 01:00:09	2	2	12	2	4	21	2	140.20	31	89.32	CHANGED	hK+lScpLsphLspDaluFSlNNNPll..SpISstSFuQhh.VhpQYSlFPKplluhh.hAthph.htsWsGVuEELLpNlNEEMGushGtIo.....HYTlLR+uLc-ulGlsVsNshPSVATppFlcoVcuLl-+ps.-hVLGusYAlEooAIPELhLl+ELV...tEuApcKcLsappohl.pFF-hHLD-lElEH+DcLtshluuYIpsEE.......QatEFt-GFpAsIDsM-sWWo-LspEth	......................................................................................................................................s.lstEl.tNh....EE.s.....................Hh.hhtpuh.p..h...t....hs...lpshh..P...uTpthh.pl.tlh.hps..phshGshYAhEstul.Eh.lhhcls...tchs..ct..ht........F.aphHl.DthE.tHpstL......tp.hsthlt.tp.............hhtGhhshlshhpsaWptL.....s...	0	2	2	4
+12823	PF12982	DUF3866		Protein of unknown function (DUF3866)	Bateman A	agb	Jackhmmer:Q18B83	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 352 and 374 amino acids in length.	25.00	25.00	112.90	28.00	22.90	22.40	hmmbuild  --amino -o /dev/null HMM SEED	320	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.92	0.70	-5.46	30	119	2010-05-28 08:24:37	2010-05-28 09:24:37	2	3	117	0	62	121	2	317.00	43	87.68	CHANGED	tRAlsYspLsGpscsGDcVlLNsTAlthsLGTGGYcaVlus.sphs.s........ssGHIMKhRYTPhQhpVLusEEpcSPaHchhpssc.oLcGhPVlVu-LHShLsPlssul..+pts.....Ps...........hRluYlMTDGGALPltaSpsVtpL+cpGhlsuTlTsGpAFGGDhEAlNlaouLlAA+pllcADlllVu.GPGllGTGT+aGFSGlptGchlsAlssLGG+PlulsRlShADsRtRHpGlSHHolTslsclsLsssplslPhh.tt-.............ttshlpcQlpsh...sp+Hp....ll..hl.sssthtpsLpphslploTMGRuhp-DssaFlAsuAAuh	.......................+AlsYsplsGpspsGDcVlLNsTAlthsLGTGGYshVl..us.sths....-ss...................ssGH.lhKhRYTPhQhtVLus-EppSPaHshhpp.sc...sLcGhPVlVu-LHShLssls.uul.+........p...t.s.....Ps...........h+lsYlMTDGGALPlhaS+sVttL+cpGhlsu.TlTsGpAFGGDhEuVslaouLluA+cVlcADlslVu.GPG.lGTGT+aGFSGlptuchlsAlstLGG+Pluh.RlShuDtRpRHpGlSHHolTshsclshsssslsl.Ph.h.ss-...................htthlppQlpt.......tp+....H.p..ll..hl...ss....sth....tp...h...L....c....p....h....s.lploTMGRuh-pDssaFlAAuAAu.h..................	0	36	54	59
+12824	PF12983	DUF3867		Protein of unknown function (DUF3867)	Bateman A	agb	Jackhmmer:Q18BR7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.	27.00	27.00	131.90	131.60	22.60	22.60	hmmbuild  --amino -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.29	0.71	-4.31	10	47	2010-05-28 12:03:52	2010-05-28 13:03:52	2	1	46	0	9	31	0	187.50	55	98.74	CHANGED	D+IIDFNELKNKVKDKDlDKFEsYIYSLYYclApGKLoMuDFS+cIhcYMEENNISQEKFhNIQKKhhER....YGhDsu-IEcQhKshGlDssshu...psssY...........................Esl+KohuFQEKYKs+IpsKosopYaIKN-KNDlclllEpEcVlLpSsKKIDLsDsELNEFLCSYKKllcDKKLcIslCEslKpY-Y	.D+IIDFNELKNKA+DKDlDKFEpYlYsLYaSV.spGphoMu-FS+cIhcYMc-NNISQEKFlNIQKchhER....YGhD.....hp-lEcQhKshG..lDhsslG...psssY...........................Esl+Ks..lSFpEKYpuKlpsKslopYaIKN-KNDlclll-sEclhLpSsKKIDL.pDoELNEFLCSYKKhhpsKpLpIslCEslspYsY.....	0	5	9	9
+12825	PF12984	DUF3868		Domain of unknown function, B. Theta Gene description (DUF3868)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_1065	Family	Based on Bacteroides thetaiotaomicron gene BT_1065, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.40	27.30	26.60	26.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.45	0.71	-4.57	11	235	2010-06-17 22:02:38	2010-06-17 23:02:38	2	7	74	0	30	212	2	109.50	21	24.44	CHANGED	+phhhlhhhLhlhsh...sh.AQst...apGtlslssspLcQcG-olhlshslslpslplcSppulslsPhLhS....uspphpLPplllpG+pchKsYcRplAltstpccspath......llht	........................................h.....hhh.h.lhhhsh.......sstAQph.....tstlplssh.p.l.pp..pGc.p..lhlshslsl.s.s.l.plsoscslhLoPlLts.........uscpht..LPslhlsG+p.+.phh..p..Rphuh..ptp................th.h......................	0	7	25	30
+12826	PF12985	DUF3869		Domain of unknown function (DUF3869)	Ellrott K, Bakolitsa C	kellrott	JCSG structure PDB:3KOG	Family	A family based on the N-terminal domain of 3KOG, which shows weak but consistent remote homology with adhesive families such as immunoglobulins and cadherins, suggesting it might form an attachment module.	20.40	20.40	22.30	28.10	20.20	18.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.42	0.72	-3.60	10	29	2010-06-17 22:50:21	2010-06-17 23:50:21	2	2	22	2	4	27	2	110.80	32	32.71	CHANGED	shFTSC.EKEEFNVs.lcsssApATIusTVhDhsoG..sslT............oussTluuuu.....ssplAupotshsA..ostsYho.uospVplPALscGQaAslsVoIhLQchtuAscsss	..shFTSC.EKEE....h..sl.....s..spsssAphhIssoVhDssTG..pslo............oApsTlusuuh........hssplA.tpu.h...slss...ssssYhs.sstsVplstlpsGQhushsVslhLpp.tsst..s..........	0	0	3	4
+12827	PF12986	DUF3870		Domain of unknown function (DUF3870)	Ellrott K, Bakolitsa C	kellrott	JCSG structure PDB:3KOG	Family	A family based on the C-terminal domain of 3KOG which shows structural similarity to pore-forming proteins [1][2], suggesting it may have a lytic function. 	22.00	22.00	23.00	28.10	21.10	17.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.17	0.72	-3.74	19	200	2010-06-17 22:53:45	2010-06-17 23:53:45	2	2	158	1	42	130	0	94.70	40	81.03	CHANGED	lYIlG-A+os.sNsITcpYphFFIuFllcccsscIl..Dh-souTlpLTpsFl+plFlG+shhc.p-tlhp.ElcpRYaGSSQKAllVAY+cAhpKYpp	................YlsGcAKsPpsNsITchacoaaluhlls+cTGcIl..DA-CosoltLTppFV+pLFls+slpD..stLlt.ElcsRYFGSSQKALlsAlKDAp++Yp....	1	18	33	35
+12828	PF12987	DUF3871		Domain of unknown function, B. Theta Gene description (DUF3871)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2984	Family	Based on Bacteroides thetaiotaomicron gene BT_2984, a putative uncharacterized protein  As seen in gene expression experiments  (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	34.00	33.90	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.83	0.70	-5.73	13	110	2010-06-17 23:00:13	2010-06-18 00:00:13	2	1	53	0	17	109	3	294.40	52	93.83	CHANGED	opNhG.EaAEEAsII..psspspcpspFIEANTpElTLpHLKNDCIlPVFAKDNElTISHpsFIEsVa-AAsoFFuGEpIspP-IRVSHlIKGRIPEAIpKsAspLLEuDKThYYERhAFsI-IPTIYETVsGN+LsLoIGGVRAYNchNLY.SKKusE+FKlFIGF+spVCoNhCloTDGYpsslEVoNopELYpulLELFpsYNPAKH..lHLMQoLusThloE+QFsQlLGRMRLYQsLPpuhQKplP+hLlTDoQINsVAKAYlsD-NFGuh..Gs-lSMWchYNLLTGANKSSYIDSFLDRulNATElusGIssAL.+G.D-+..YpWFl	...........................p.hE-AsIl..ps.t...ppps.FIEANTpElTlpaLcp-CIlPVFuKDNEhTISH.sFI-sV.-AApsaFsGEplppP-IRVSHlIKGRlPpAlpK.sspLLEsDKTIYYERhAFshcIPTIhEslpGN+LsLoIGGVRAYNc.NLY.SKKus.E+FKlFIGFpspVCsNhCl.oTDGapsplcVhssp-LYpusL-LFppYNsAKc..l+LMpsLuso.hoEpQFsQllGRhRLYQsLP.u.pKp..lP+hLlTDoQINsVA+uYhsDcNFush..ssslSMWchYNLLTGANKS.SYIDoFL-RulNATElusGIspAL.pG.Ds.c..YpWFl.......	0	4	16	17
+12829	PF12988	DUF3872		Domain of unknown function, B. Theta Gene description (DUF3872)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2593	Family	Based on Bacteroides thetaiotaomicron gene BT_2593, a conserved protein found in a conjugate transposon. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	29.40	32.30	26.30	23.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.61	0.71	-4.63	21	300	2010-06-17 23:03:44	2010-06-18 00:03:44	2	1	109	2	24	255	3	133.40	51	87.93	CHANGED	hlsplhshss.lshuhlsloAC..sc-LDlQQsYPFoVETMPVsKcIspGETsEIRCpLpR-GcFssTpYTIRYFQPDGcGpL+h-cGTVhhPNDRYPLscEpFRLYYTStS.s-pQoIDlYlEDsa..GphpQloFsFNNcs	........l...phhsh.sh.lshsshsLsuC..-c-.LDlQQuYPFoVEoMPV.cclspGpTsEIRCpLKRpGcFssTtYTIRYFQ.DGcGpL......+h.DsGhsFhPN...........DRY.Lp...........c...........-.pFRLYYTStS.s-pQslcVaVEDNF..GphhpLsFsFNNc.......	0	7	20	24
+12830	PF12989	DUF3873		Domain of unknown function, B. Theta Gene description (DUF3873)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2286	Family	Based on Bacteroides thetaiotaomicron gene BT_2286, a putative uncharacterized protein.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.60	27.30	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.39	0.72	-3.85	9	114	2010-06-17 23:08:19	2010-06-18 00:08:19	2	2	63	0	6	83	0	67.20	61	90.38	CHANGED	tsphshNGVSlCpssGcEKYpKaphslt.t+tpphYQYDYRcs.ssELFSCVusTL-ECRcpRDcWLppKp	.....ppMTlNGVSTCppuGpEKYE+FQ.GlG.RR+RThlQYDYRHs.DGELFSCVKPTLDECRptRDcWLstKp.........	0	3	5	6
+12831	PF12990	DUF3874		Domain of unknonw function from B. Theta Gene description (DUF3874)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4228	Family	Based on Bacteroides thetaiotaomicron gene BT_4228, a putative uncharacterized protein  As seen in gene expression experiments  (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.00	27.20	25.90	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.35	0.72	-3.86	12	222	2010-06-17 23:12:49	2010-06-18 00:12:49	2	4	61	0	19	204	0	72.40	34	14.28	CHANGED	Y+hss.EEVhtsCFR..hstt.sEcsh.LSAusIFphLpctpPAAMRGssshphuplLhuhGlcRpHTcaGNVYpV	........hsshEplFhphFR..sApp...tE-uchLoss-IhphLp+pssh.s.hps.s.plspFGRlLpph.Glpp+HTppGslYpV..........	0	9	18	19
+12832	PF12991	DUF3875		Domain of unknown function, B. Theta Gene description (DUF3875)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4769	Family	Based on Bacteroides thetaiotaomicron gene BT_4769, a conserved protein found in a conjugate transposon. As seem in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231). It appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	27.50	27.20	25.40	26.50	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.69	0.72	-4.28	17	294	2010-06-17 23:17:18	2010-06-18 00:17:18	2	4	123	0	37	265	8	53.20	67	7.11	CHANGED	RNlhKssTLESKFPLLAVEpsCIlSKDADlTVuFcV-LPELFTVTuuEYEAhHS	...........RNh.KhoTLEsKFPLLuV..E.p..GCIlSKDADITVAFcVELPELFTVTuuEYEAIHu...	0	13	32	37
+12833	PF12992	DUF3876		Domain of unknown function, B. Theta Gene description (DUF3876)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0092	Family	Based on Bacteroides thetaiotaomicron gene BT_0092, a conserved protein found in a conjugate transposon. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or other bacterial species vs when in culture [1,2].	27.00	27.00	28.00	28.00	25.40	24.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.09	0.72	-4.05	19	215	2010-06-17 23:20:33	2010-06-18 00:20:33	2	1	93	0	21	156	1	93.10	42	80.70	CHANGED	hpsspp..shchcplsGsWcSlst+PsVhla+-ucpYplolhthsthstphpPpTY.l.p.ccsGshFIsTGa.Rl.lsYcptpDlLohSstG...-YlRs	...........h..oCp..sspch-tlsGsWcSVp.G.+.PsV.hIY+-....Gcs....Y+VTlhp+SshpRph+PcTY.l.p..E-sGsLFhsTGa.RlsluYscusDlLohSPsG...DYlR.....................	0	6	14	19
+12834	PF12993	DUF3877		Domain of unknown function, E. rectale Gene description (DUF3877)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_0237	Family	Based on Eubacterium rectale gene EUBREC_0237.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	129.70	129.40	26.10	25.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.23	0.71	-4.71	14	33	2010-06-18 21:49:19	2010-06-18 22:49:19	2	2	33	0	4	31	2	175.20	45	90.95	CHANGED	acRLE+sLIDlIKEEQAKLGYRKEpIRLYYPLSSLNHFFpscsss-cMpctLpp............Fschhcp+LGclpVopKs-RFCFpIPEpGu-YVHEphptNEFI+-LIELlu+HGCTh--IhsLF+paS-plhhEcMsNGEFDhhIpFpp-s-DsYYYCFKDEGCHIIYHRFLPEDYsDFGF	..ap+LE+slIDlIKEEQhKLGYc+EsIRLYYPloSLN+Fhps..-s..s.tccMpptLpp............FscphpppLG-lclo.pKs-RFChpIPtcGupYVHEpsscsEFIK-Llplluc.HGCThE-lhclFc....pYS-.plhh....EchpsG.EFDhllpFp-ss.DsYYYCh+DEGCHlIYHRFLPEDYtDFsF...	0	3	4	4
+12835	PF12994	DUF3878		Domain of unknown function, E. rectale Gene description (DUF3878)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_0973	Family	Based on Eubacterium rectale gene EUBREC_0973. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737). it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	63.70	63.50	20.50	19.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.05	0.70	-5.24	3	29	2010-06-18 22:00:08	2010-06-18 23:00:08	2	1	28	0	2	27	1	283.00	34	86.14	CHANGED	pISRAFphLAElFEYQVFELCVuE-....pYlIPYMMNDAVECYLol+GsploGcYp+D-ElEsuupLttcEcRYGLIVHQGEENVFTLWFDELcEHpsCF+YHEIGHFWV-GQEQWRQLVYMIGTItEKYpYLGEEYCNEsEptIMSLIEFAPFRhWoPVsEDLEEa.YPAThEGIDCMEcLARcAuD+DYLKWIc+YR+aPo++hE+LLuR+LtDPKRQcLYEhICccVpsAS-sYPpRNYGEcINpRIQ+KRcpl-KKLLEcGFTGpYPpYpKKphoVsVTEEHPFTluhLEaEDFKFKlQ	................................sh.hLtplh-.p.FE.lh...h.s-p................phhls..YhMNDAVEsaLsFc..su+hoGpYpp..-h........E...sthtApl...ptp......-s..tYsLlV+Q......t-.sVh.T...laFcclp.chphYpYtcIGHFWVcGhE.hRpL.YhluhlpDKacYLGcchCs-pEtcLhpLh-FsPhp..h..YssVsEp.........c-.....asso..t..EulshMpclAtcssDcshl+hLchYc+pPs+hhp+hluthLpcs++tplhchlhcclppAopsYspRsaG...pp...hc...p+hp...c...h...tcphcp...cLhc...pGhpsh....................................................................	0	1	2	2
+12836	PF12995	DUF3879		Domain of unknown function, E. rectale Gene description (DUF3879)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_1343	Family	Based on Eubacterium rectale gene EUBREC_1343.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	27.90	32.60	25.00	26.70	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.20	0.71	-4.70	3	33	2010-06-18 22:08:48	2010-06-18 23:08:48	2	1	13	0	7	33	6	165.70	48	87.36	CHANGED	plNSSSVQcQLKAAGIDTNSKQYKAAlSEMM+sGNGAMYTNIQAIKNLMS+YDKDGDWINPsTGLAGLLVTDENcNS+KRIISIPESS+EEMFELTKKEFLpENGVpNGDTTKRo-VYNNLYRKM-KcDRLAAGYTLEcYERQYRQAFsDAAKsADPsWEAGKPIhAGALDcITRESAEoG.........RKSs-	................................sGIsTNSKpYKA.........s.........l..pp...........MMpstpthhapsh...tu.....IKNLMpQaDpsGDhlss.sGlsGhsVTscs.sSap+IlSlsEs.+pcMF-.sK+EFlpENGh.NGDTTKRpslapsh.hphsK-cRLuAGWTLEQYEtQYRpAhhtAsKsAsPsW+sGpshssuhLDslTRESsEus.......................	0	4	7	7
+12837	PF12996	DUF3880		DUF based on E. rectale Gene description (DUF3880)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_3218	Family	Based on Eubacterium rectale gene EUBREC_3218.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737),  It appears to be upregulated in the presence of  Bacteroides thetaiotaomicron vs when isolated in culture [1].	21.70	21.70	21.70	21.80	21.20	21.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.75	0.72	-4.07	48	247	2010-06-18 22:21:15	2010-06-18 23:21:15	2	10	156	0	76	245	24	76.70	27	17.81	CHANGED	WhsDsPhhtlas.h.sl.hsshN.hIFhFDpsphppa+shGhpplaaLPLAssssRhs.hhtp..................t.ppapsDlSFVGs..hYpp	...............................WhsDsPhah..hs...h.....pl..hs..hs.hlFThDt.s.slpha+.s.h.GhppVa.aLP.LAsssph.apPhhtp.....................ppaps-lsFlGssa....................	1	35	64	67
+12838	PF12997	DUF3881		Domain of unknown function, E. rectale Gene description (DUF3881)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: EUBREC_3695	Family	Based on Eubacterium rectale gene EUBREC_3695.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE14737), it appears to be upregulated in the presence of Bacteroides thetaiotaomicron vs when isolated in culture [1].	27.00	27.00	106.10	105.20	21.80	20.00	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.72	0.70	-5.40	28	81	2010-06-18 22:31:02	2010-06-18 23:31:02	2	2	75	0	8	77	13	258.60	41	95.97	CHANGED	LRAIGFSslpp+c-lcclLcplhcphsppphl..p.pcspcasEhp+-ausshGIsVpG-hDc.....sspFch-YYaPYapGssloopt-lslE++s-+EuYsGlCDDh+lGloLIFYLQNsh-Yhcp+....................thsphshphpulsLSGLuspGpILLPlpKscpppcp....pcppscs.RppLlsAA+sGDpsAIEoLTl-DIDhYStlSRRlhsEDlaSIVDThFMPaGlECDpYSllGEIl-lcpppNphTsEplY.hcL-CN-lpFclCINcpDLlGEPtVGRRFKGpIWLQG	............L+ulGFuplpp+p-lcclLcpl..c.p.hsp.pphl..p.pc....tpphsEhpp-h........usshGIslhG..ch-c.....pspFph-YYaPYhpusslooht-sslE++h-+EsYsGls-Dh+lGloLIFaLpNshEYhppc.....................htt..hpspulsLoGLuhpGpILLPlpKsppphcp....p.pptscsRppLlpAA+sGDpsAhEoLTl-DhDhYSplS+Rlh..pEDlaSIV-ohFMPhGlECDpYSllGEIhplcpppNthTtEplY.hplcsN-l.FcVsIscpDLhGEPtlGRRFKGplWhQG................	0	6	8	8
+12839	PF12998	ING		Inhibitor of growth proteins N-terminal histone-binding	Wood V, Coggill P	pcc	Pfam-B_205 (release 24.0)	Domain	Histones undergo numerous post-translational modifications, including acetylation and methylation, at residues which are then probable docking sites for various chromatin remodelling complexes. Inhibitor of growth proteins (INGs) specifically bind to residues that have been thus modified. INGs carry a well-characterised C-terminal PHD-type zinc-finger domain, binding with lysine 4-tri-methylated histone H3 (H3K4me3), as well as this N-terminal domain that binds unmodified H3 tails. Although these two regions can bind histones independently, together they increase the apparent association of the ING for the H3 tail.	23.70	23.70	23.80	23.70	23.60	23.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.25	0.72	-3.76	79	827	2010-06-28 12:29:44	2010-06-28 13:29:44	2	12	279	6	538	851	2	102.20	26	28.97	CHANGED	shL-cal-sl-sLPtElp+hhs.l+-lDtp...hppthppl-pphccalppstt..............................ht.p....pcpphhppIpcphpcsppht-EKlplusphh-ll-++h++LDtchcph	.......................................................hl-cal-s.....l-sLPh-lp+phs.h+-lDtp..........hpshhp.p.l...-phhpca..hppspp...................................................................................t.p...pcpphhppIppshtcstchuDEKlp.lupphh-l.l-++l++LDtclth.................................................	0	154	245	401
+12840	PF12999	PRKCSH-like		Glucosidase II beta subunit-like	Coggill P	pcc	Wood V	Family	The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1].	26.30	26.30	28.10	27.00	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.49	0.71	-4.69	5	445	2010-06-28 12:42:30	2010-06-28 13:42:30	2	22	268	0	317	453	13	145.60	32	32.92	CHANGED	lhlPlLuluLhlusA.lscLRGVuPDcLcLYpPD.ENGN..WKCLNcscIhLSFDQVNDDYCDCPDGSDEPGTuAC.pNG..KFYCsNcGaIPuYIPSF+VDDGVCDYclCCDGSDE..plG+CPN+CsElAcpacchpsE+Nspl+sGLKIKccllltup+KsDElpp+hcELccoLhAcppct	........................................hhhh............................hGl..t..thY.p........t.......a.pC..l.ss..s....th......lshsp..l..ND-aCDC.s.D.GSD.EPGTu.A...C....s...........ps....................tFaCp.....N...t.G..a..hs...h.....h.....lspsp..VNDGlCD...CCDGSDEh.............st....s...t..C......spCtpht.pt..pt..p..t.....p.hp...tu....ht.h.+t..hh....t.....t.h....t....t..............tp.tt.t...............tht........................................................................	0	105	178	269
+12841	PF13000	Acatn		Acetyl-coenzyme A transporter 1	Coggill P	pcc	Wood V	Family	The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.	102.60	99.30	109.50	100.10	102.50	99.20	hmmbuild  -o /dev/null HMM SEED	544	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.79	0.70	-5.99	2	464	2012-10-03 03:33:39	2010-06-28 15:33:01	2	7	252	0	348	478	3	242.70	26	72.83	CHANGED	phYhLIhLYLhQGlPhGLshGolPahLKs...psSaosLuhaShAsYPYSLKllWSPIVDohYs+phGRR+oWllPs.hl.u.sLhhhuasl..........Dsahs+GsuhlpSho....TW.F.LLVFlCATQDIAVDGWuLshLs.EpLSYASTAQTlGLNhGaFhSFTIhLshsSs-FANpahRsIP.scGhIoLuGYhKF.uhhhhlholhlhF..............................aD-us...pQphusIp.ha+shhtsLpLKshRpLhhlHhluKhuF.sNEshT.LKhhE.GhppE.LulhlLIshPhtlhhGhYss+hSs.+s............................Ls.WLhGahGRlsuhlLsohlV.......+pFP........hFh.lhhpahLsu.hsTlQFlulusFHo+luDPhlGGTYMTlLNTLSNhGGoWPphlhhpMhshhTV.pC.ThP...+lhsotsuphptC.phLsGTshhhRDGYYlTsllsIhlul.lhhuhlp.hlh+LpphPISSW+h........T	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p...............................................................	0	113	181	282
+12842	PF13001	Ecm29		Proteasome stabiliser	Wood V, Coggill P	pcc	Pfam-B_682 (release 24.0)	Family	The proteasome consists of two subunits, and the capacity of the proteasome to degrade protein depends crucially on the interaction between these two subunits. This interaction is affected by a wide range of factors including metabolites, such as ATP, and proteasome-associated proteins such as Ecm29. Ecm29 stabilises the interaction between the two subunits.	20.50	20.50	21.00	21.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	501	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.69	0.70	-6.01	45	308	2010-06-28 15:32:17	2010-06-28 16:32:17	2	15	231	0	217	302	1	426.60	25	27.72	CHANGED	ls+V-LRl.ALA-sDccLcphLspaLsPlLLKLuSspsuVRpKVlcllpH.lNpRlp.u.tsIpLPVssLLcQacpss.....ssshV+pFsllYlppGl-RL.sssc+hpllPpllpGI...........S......ptshsptuhhFtllh.+lL..h+h..P.cssp-ppphcsp..htl.t-...p.sthLh.hhsph.hh.......t..................................ss.sssulssppsshhoh.t.....stsssh.s..pLpcsKhslLcFLsuuhh...............................s-tphhlshLlASuD............ss.ppluchu-phLK+hpss........hEsspllppLapLah...........................s.t.tptt.PspssLph+ILshLsKShtAssphspshplhptuLhos.h..ss+lcshshphh.................................spshpphssphlptlpshlhspshshh.......spsp.t......tpshplRshsYcslGhLsp+tsphh.c-......hsllpaLFcuL..cspss-ltsuIpcALuulhsuhsp..p.............................t.thphhh.lh.ttpp...........p.ttssRasAl+aANpsaPasDssuRalsllu	......................lp+l.hRl.uhA-sD.ppLpphlppaLsPll....L....KLuS.s.pt.uVRp..............K.........V...............h...pllt...H.lspRlp.s.splpLPltsLl.Qappss................sshl.ppFsl.lal..phuhsRl.sspcphplhPtllpsh............................p......p.t.hhphhh.h..hhh...+h............p....s.p..p.t....pp.pph.....hl.s....h.phhLh.hh.hh...............................................................tsth......t...shhoh............st..ssh.h....p..pL.pphK....lsllpFl.tut.h...................................................s-.phhh.hlhAu.uD............sp.pp...l.ushu-..L..K+hts.....................hp..s.sllppLaplah..............................................s...t.th.Pspstlph+llshL.+.Sh.Asp....th..st.hpll.t..slh...us.........pt.+hcthshphh................................................h...ths..hlp..ltshlhsthh.hh......................tps.phhshuYpslGhL.upphsp.h...h.ppc..............hsllt.LFpuL.........ppp.tsphthuI.ppALsthhsshtt..t........................................t..hhh.h..lh.t.............................................................................p..htsR.sul+auspshs.pch.uRal.llu..............................................................................................................................................................................................................	0	63	112	179
+12843	PF13002	LDB19		Arrestin_N terminal like	Coggill P	pcc	/wood V	Family	This is a family of proteins related to the Arrestin_N terminal family.	21.60	21.60	21.90	21.60	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.25	0.71	-4.80	5	121	2012-10-02 22:29:00	2010-06-28 16:40:07	2	3	103	0	96	133	0	181.80	37	30.53	CHANGED	VpLsLlQKVHFHKPFhsshpuIQTCpNCpoKTTcl+SWDIQsNTs-LsVGoasaPFSaLIPGSlPAoooLGusuETplKYELpAsVsYhD............PctthSs.uKcplLpLsMPIsVTRSlhRGPDKNSLRVFPPTELTAsAVLPNVVYPKSoFPLEMKl-GlSpGD....RRWRMRKLoWRIEEpTRI+uHAC-pHKH-L	...................................hphhtplphpKP..............s..........hpsCtsCpsphs-LppWph....L.spst..s.LppG.p.HsaPFSaLlPGpLPuSss.......s.s.l..sp..lpYcLpAp.uph.....................ss.up...t..lphphPlslpR..ol.h.t.G.s.D..+..sSlRl....FP..P.T.slsAsssLPsVlaPtu.o.FPlph+LcGl..s....s..ts......pRWRlRKlsWRlEEpt+lhu.ACs+Httc...........................................................................	0	18	48	84
+12844	PF13003	MRL1		Ribosomal protein L1	Coggill P	pcc	manual	Domain	This family includes putative ribosomal L1 and L10 proteins and fragments.	21.90	21.90	23.10	22.40	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.91	0.71	-4.34	7	64	2012-10-01 21:21:48	2010-06-29 16:43:58	2	1	40	0	28	58	2	142.90	51	46.98	CHANGED	M..................................................hs..pshc.st.htscppthsplph..............................................................slYh..............................................................................sslhhsp.hhsphppssVs	...................................hhtt.......................h...hs.RpaAAA.....pKs..sKKsKKss.KcKss-EKp.D-lEKhKsYsaMEuEPEDDVYLKRLYPRpIYEVEKAlcLLKKFQhLDFTsPKQ..............sVYLDLTL.DMsLt....K.K...KKVEPFs............................................................SslpLPYPFsSElNKVsVF.	0	2	5	11
+12845	PF13004	BACON		Bacteroidetes-Associated Carbohydrate-binding Often N-terminal	Coggill P	pcc	Rigden D	Domain	The BACON (Bacteroidetes-Associated Carbohydrate-binding Often N-terminal) domain is an all-beta domain found in diverse architectures, principally in combination with carbohydrate-active enzymes and proteases. These architectures suggest a carbohydrate-binding function which is also supported by the nature of BACON's few conserved amino-acids. The phyletic distribution of BACON and other data tentatively suggest that it may frequently function to bind mucin.	20.00	13.30	20.00	13.30	19.90	13.20	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-10.03	0.72	-3.75	432	1404	2010-07-09 08:33:15	2010-07-09 09:33:15	2	119	153	0	197	1347	35	73.70	18	20.89	CHANGED	sls..............ls...............................................ssss...W...l..........sls.tst.....................tts.lsls....lstN...ss.tp...t....Rp.upl...pl.....................t........tp........ts.......l.sl....p..Qtu	.......................................................................hp...ss..................................spssss.....W........l...........sls.sst...........................tpsplsls..ss.t.N....ss.sp...t..Rs..upl...pl.............pss....shs........tp......l..sl..p..Qt.......................................	0	119	177	197
+12846	PF13005	zf-IS66	HTH_Tnp_IS66;	zinc-finger binding domain of transposase IS66 	Coggill P	pcc	IS-finder	Domain	This is a zinc-finger region of the N-terminus of the insertion element IS66 transposase.	20.00	20.00	20.00	20.00	19.90	19.80	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.54	0.72	-3.99	190	3219	2011-09-20 07:06:31	2010-07-12 16:03:04	2	18	1017	0	565	2843	332	45.40	39	10.71	CHANGED	psptCss..CGs.plp..plGc-.l..sEpL-hlP.uphc.VhcahR.+auCpp..C.c	..................ppsCPs....CGG.pLp...hlG--.s...uEpL-lls..ush+.VI.cphR.KhACsp..C-............	0	111	286	407
+12847	PF13006	Nterm_IS4		Insertion element 4 transposase N-terminal	Coggill P	pcc	IS_finder	Family	This family represents the N-terminal region of proteins carrying the transposase enzyme, DDE_Tnp_1 (that was Transposase_11), Pfam:PF01609, at the C-terminus. The full-length members are Insertion Element 4, IS4. Within the collection of E.coli strains, ECOR, the number of IS4 elements varies from zero to 14, with an average of 5 copies/strain [1].	21.80	21.80	22.00	22.10	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.07	0.72	-3.97	36	1119	2010-07-12 15:15:56	2010-07-12 16:15:56	2	6	317	0	125	971	61	88.10	61	26.57	CHANGED	sshsslusLschlPh-hl-pslptTGpushR+.RcLPuchsVahVluhuLapcps..hp-VhppLshsLss................hphsusSAlspARpRLGscPlctLFcp	.............SL..RNPLTSLGDYLsPELISRCLAESGTVTLRK.RRLPLEMMVWCIVGMALERKEP..LHQIVNRLDIMLPG...............sRPFVAPSAVIQARQRLGuEAVRcVFs.c.....................................	0	19	55	80
+12848	PF13007	LZ_Tnp_IS66		Transposase C of IS166 homeodomain	Coggill P	pcc	IS_finder	Family	This is a leucine-zipper-like or homeodomain-like region of transposase TnpC of insertion element IS66.	22.90	22.90	22.90	22.90	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.91	0.72	-3.32	254	3061	2010-07-12 15:45:03	2010-07-12 16:45:03	2	20	942	0	489	2621	269	73.50	31	17.94	CHANGED	ppLcpplthhcRphFGp+SE+h..s.......tQhpL...h...p..-h-sststht.........sphcptsttsss.............ttt+pc..ss.RpsL.P.scLP.Rtch	.................cLptpltpLpRhhFGppSEKl....sc...............tQhch.........h..p....clptptsphp.....................tp.tc..ts......................t..+pp...ppR+PL.P.tpLP.R-p.p.....................................	0	97	233	341
+12849	PF13008	zf-Paramyx-P		Zinc-binding domain of Paramyxoviridae V protein	Karlin D, Coggill P	pcc	manual	Domain	The Paramyxoviridae, which include such respiroviruses as para-influenzae and measles, produce phosphoproteins - protein P - that are integral to the polymerase transcription-replication complex. Protein P consists of two functionally distinct moieties, an N-terminal PNT, and a C-terminal PCT [1]. The P gene region transcribes proteins from all three ORFs, and the V protein consists of the PNT moiety and a more C-terminal 2-zinc-binding domain. This conserved region consists of the two-zinc-binding section sandwiched between beta sheets 6 and 7 of the overall V protein. It is the binding of this core domain of V protein with the DDB1 protein (part of the ubiquitin-ligase complex) of eukaryotes which represents the key element of the virus-host protein interaction [3]. In the Henipavirus family which includes Nipah and Hendra viruses, the V protein is able to block IFN (interferon) signalling by preventing IFN-induced STAT phosphorylation and nuclear translocation [2].  The P gene of morbillivirus is co-transcriptionally edited leading to a V protein being produced.	25.00	25.00	33.20	47.40	21.50	16.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.16	0.72	-4.77	26	152	2010-07-13 14:16:56	2010-07-13 15:16:56	2	5	76	3	0	147	0	46.90	50	16.38	CHANGED	SlsWs..supsplpcWCNPtCuPlsstspptpCsCGpCPphCspCtpDs	......SlsWs..ssclhlpcWCNPhCS.lTsssp+tpCpCGpCPphCcpCcpD...	0	0	0	0
+12850	PF13009	Phage_Integr_2		Putative phage integrase	Coggill P	pcc	Pfam-B_5288 (release 24.0)	Family	This family is found in association with IS elements.	22.80	22.80	76.30	41.10	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.14	0.70	-5.49	22	56	2012-10-02 14:09:14	2010-07-21 11:59:58	1	14	53	0	20	60	8	318.40	30	34.49	CHANGED	PphtpWtphupcalptpsp..uhsp+hpuLspFltpYlh..shPh...sPtsahp........sppph.shlpth...........ssspspphhshlppFlcalLpphho.pD...Dp.Gp.lh.stapNPlsph..shpsh.tt...sETs+ssLPhpaIpph+phLsss..........................papDatWspp..............ssWh.Vs.p..lscsDscClaRshth.p................htplWSPVpshsLashLpLPlRohQlRhLDSGEuDshhY....ppt.spWlhN.ssphA........ppshpcGhh.++hp-st................t.sGLalsTNKTup.............sp.ppGYsIPWt.....pp-lhaWLh+LRpWQpKY.NPIscsTsWp-	.........................................................................................................................phttWtphht-alpsppt..shsp+hpuLstFhppYlhtpshsh...sPttahp............hstpph.phlcpt...........sssptpphhshlpsFlcallpchhoppD...-s.Gphlh.sta+NPls+h.....shps..p.....sEos+ssLPYpYIpchRphLsst..........................pFpDapaApp............ssDWhtVs.p..IDcs..........DPDC..VaRtpps.t................hhplWSPV+hhslashLpLPLRshQlRhLDSGEADshha........pt..spWhhN.psthA........t..ppshppGlh++hpcpt...................sGlalsTNKT...............st.tpGYhIPW........sp-lhYWL.KLRsWQpKY.NPIspPTsWs..............	0	5	9	14
+12851	PF13010	pRN1_helical		Primase helical domain	Bateman A	agb	Jackhmmer:Q54324.1	Domain	This alpha helical domain is found in a set of bacterial plasmid replication proteins [1]. The domain is found to the C-terminus of the primase/polymerase domain. Mutants of this domain are defective in template binding, dinucleotide formation and conformation change prior to DNA extension [1].	27.00	27.00	142.00	142.00	23.10	20.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.86	0.71	-4.54	9	9	2010-07-21 11:16:13	2010-07-21 12:16:13	1	3	5	4	2	12	0	132.40	48	16.02	CHANGED	tG+cEcp-...tc-hEKL+cEhsKYs+a+GKTlEAIRpElCpclK+pl..........ppKhpthhphshpVlC-uKoYu-lGIDRSRGDW+VlphLhoHGVTDlDhlhQLLPpDSKVas.PKWD..KYFlHTLtKAWphVK.aLch	..t.scpEcp-..s-c-hEKL+cEhsKYs+a+GKTlEAIRpElCpclK+pl..........ppKhpthhphshpVlC-uKoYu-lGIDRSRGDW+VlphLhoHGVTDlDhlhQLLPpDSKVas.PKWD..KYFlHTLtKAWphVK.aLch.	0	1	1	2
+12852	PF13011	LZ_Tnp_IS481		leucine-zipper of insertion element IS481	Coggill P	pcc	IS_finder	Family	This is the upstream region of the conjoined ORF AB of insertion element 481. The significance of IS481 in the detection of Bordetella pertussis is discussed in [1]. The B portion of the ORF AB carries the transposase activity in family rve, PFAM:PF00665.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.80	0.72	-3.64	2	445	2012-10-04 14:01:12	2010-07-21 13:08:03	1	5	189	0	209	1294	169	81.90	41	27.81	CHANGED	M.sHtpARLTlhGRsLLVpRVhppphshtpsupthGVShpsua+WlsRFRuEGLcGLhDRSSRP+psP+tsuPEp.cthhptRtQ	........................................M.sHpNAh.LT....htRh...chs..pp..ll..p.p.th.s...lscAAc...taGVS.htT.sp+WhsRaRspGt.s.Gh..s...D..R..S...S........R...P..p.p..o.P.p.p..h.s.s.th.tp.tIlplR..h...................................................	0	121	173	198
+12853	PF13012	MitMem_reg		Maintenance of mitochondrial structure and function	Wood V, Coggill P	pcc	[1]	Family	This is C-terminal to the Mov24 region of the yeast proteasomal subunit Rpn11 and seems likely to regulate the mitochondrial fission and tubulation processes, ie the outer mitochondrial membrane proteins. This function appears to be unrelated to the proteasome activity of the N-terminal region [1].	22.10	22.10	22.20	22.70	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.52	0.71	-4.00	148	1224	2010-07-21 12:18:05	2010-07-21 13:18:05	1	19	336	4	844	1138	8	118.00	23	35.91	CHANGED	pEsEc...........l......ulctLl+............slpcpt........ho.sl....s.p+hptptpuLtsLpp+lhphstYLpsl......ttphshspplhpplpslhsLlP..sh.......................spph...........pcphphpssD..plhlhYluplspsph...slpsllssp	..................................................................Escp....h..........ulptLh+...................slpcpt.........hu..sl....s.p+lptptpuLtsLpp+ltplttYlpcl.................ttph..s.h....s....ppl...hpplpsl..hsL.hP..sh................................spph....................pc.thphpssD.....pLhlhYluplspsph.......slpphlpp...........................................................	0	315	475	695
+12854	PF13013	F-box-like_2		F-box-like domain	Wood V, Coggill P	pcc	Wood V	Family	The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.	21.60	21.60	21.80	21.70	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.53	0.72	-4.34	7	39	2012-10-02 00:56:31	2010-07-21 15:07:26	1	2	22	0	34	54	0	97.80	19	19.17	CHANGED	sostos....huosps..tp.l..tlhDLP-ElLphIhphChctphh..hshs.shRpppch.......................................................hl..spsCptl+pl.............p.hpshhsh.s.hhhpshph...stp	...............s..............p..phtsl..plhD.LP.-LLphlhcpCspsphhtl.ppsp.shh..shtph.....................................................................hl....spppphhpt..............................................hh..........................................................................................	0	24	26	31
+12855	PF13014	KH_3		KH domain	Coggill P	pcc	Wood V	Domain	KH motifs bind RNA in vitro [1]. This RNA-binding domain is required for the efficient anchoring of ASH1-mRNA to the distal tip of the daughter cell. ASH1 is a specific repressor of transcription that localizes asymmetrically to the daughter cell nucleus.  RNA localisation is a widespread mechanism for achieving localised protein synthesis [2].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.68	0.72	-7.98	0.72	-4.24	992	970	2012-10-02 00:34:43	2010-07-21 15:11:14	1	161	261	0	679	13179	2478	42.40	26	10.20	CHANGED	hhutlI..G+s.Gp.s...Ipplp.ppo.u.sp.Iplsp..............sss.spchlplpG	...........hGtlI...G+s..Gp.s.......Icplp..ppo.G.sp.Iplsp.............................sss.spchlplpG....................................	0	314	459	633
+12856	PF13015	PRKCSH_1		Glucosidase II beta subunit-like protein	Coggill P	pcc	Wood V	Family	The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1]. The beta-subunit confers substrate specificity for di- and monoglucosylated glycans on the glucose-trimming activity of the alpha-subunit [2].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.89	0.71	-4.75	5	406	2012-10-02 14:19:22	2010-07-21 15:42:45	1	19	259	0	274	570	7	146.00	26	30.43	CHANGED	Lp+clDEhcc-IcsI-p-lotlhEsLNpcaGhDDIaRAl-GppsscKlGGYsY+lsFhuSlaQ.....-DIpIGsFcctE...........Gs+LhY-cGuKCWNGP+RSAIVcVECGcsN-LlSVuEPEKCEYplpV+SPAuC...sss.hhKSLscE..EphAsF+I........s-hDEL	...................................................................................................................................tp..................t.......................t.......th...G....p.t.....at.....Lts..p...Ch.p..h.ptsp.Y.hYc..hC.........a...pp...spQp....................sttps.......p.........lGp...a...p....p..a.ph.................................................tph..h..s...h..h..ap..s..Gs.pC......W....N.....G.P........s.R.o.sp.......Vp.LtC....G...p.....p....s....c.....l....h..p.......V...s......E..Ps+..CpYthphpTPtsC...p................................................................................	0	110	156	224
+12857	PF13016	Gliadin		Cys-rich Gliadin N-terminal	Coggill P	pcc	manual	Family	This is a cysteine-rich N-terminal region of gliadin and avenin plant proteins. The exact function is not known.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.13	0.72	-3.78	28	2134	2012-10-01 19:46:35	2010-07-21 17:26:44	1	3	145	0	43	2573	0	79.20	44	32.15	CHANGED	QQQ..........hp..l.ppQLsPC+sFLhQQCsP........hhhsahpSphhQpSsCQVhQQQCCQQLtQIPcQsRCpAI+slVpAIIh	....................................................................................................................QQQ............hlQspl..pQQLsPC+sa.LhQ.Q.Css.......sh..sh..s...p.Sp.hhtpS.uC.p.lhQQQCCQQLsQIPpQsRCpAI+ullauII..........	1	0	3	21
+12858	PF13017	Maelstrom		piRNA pathway germ-plasm component	Zhang D, Coggill P	pcc	Zhang D	Family	Maelstrom is a germ-plasm component protein, that is shown to be functionally involved in the piRNA pathway. It is conserved throughout Eukaryota, though it appears to have been lost from all examined teleost fish species.  The domain architecture shows that it is coupled with several DNA- and RNA- related domains such as HMG box, SR-25-like and HDAC_interact domains.  Sequence analysis and fold recognition have found a distant similarity between Maelstrom domain and the DnaQ 3'-5' exonuclease family with the RNase H fold (Exonuc_X-T, Pfam:PF00929); notably, that the Maelstrom domains from basal eukaryotes contain the conserved 3'-5' exonuclease active site residues (Asp-Glu-Asp-His-Asp, DEDHD). However, the animal and some amoeba maelstrom contain another set of conserved residues (Glu-His-His-Cys-His-Cys, EHHCHC). This evolutionary link together with structural examinations leads to the hypothesis that Maelstrom domains may have a potential nuclease-transposase activity or RNA-binding ability that may be implicated in piRNA biogenesis. A protein function evolution mode, namely "active site switch", has been proposed [1], in which the amoeba Maelstrom domains are the possible evolutionary intermediates due to their harbouring of the specific characteristics of both 3'-5' exonuclease and Maelstrom domains.	18.90	18.90	18.90	21.20	18.70	18.80	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.26	0.70	-4.85	27	133	2012-10-03 01:22:09	2010-07-21 17:42:00	1	4	76	0	89	141	6	189.70	29	46.12	CHANGED	+......sschalPAEluhscaSLcp.G.lhs.apshIsPGpl.hG.hthcsppHop.sTHp.lPlsssshGcpshsplhpplhpalptp.........p........c.hs......................laopscplshVpsChcaLt............spsp...t..............lpVhslp.Lhhsl+ppshpht...p.h.shpls..sshhppsha-apsshuCpaHEc...spspaCshSh.VpRauahhschh...CtDluIphhss+H..........lP.ptcs	.................................................p...spptalPsEluhscaSLpp.G..IhspaHphIs.......P.G.plshG.hthcspttop.soHp.lP.lss........t.huc.shsplhpplhp...alpss.................t.........phs.......................laspscphshVp.Clcahs............ptsthppp..................lplhslppLhhtlhpp....th.........pp.stphs...pshhshsha-asssh..pCcaHEc...Dh.haCuhuh.sp+hu..aslss.h...sp.hulplp..tH...lP.p..s.....................................	2	26	30	64
+12859	PF13018	ESPR		Extended Signal Peptide of Type V secretion system	Coggill P, Desvaux M	pcc	Desvaux M	Domain	This conserved domain is called ESPR for Extended Signal Peptide Region. It is present at the N-terminus of the signal peptides of proteins belonging to the Type V secretion systems, including the autotransporters (T5aSS), TpsA exoproteins of the two-partner system (T5bSS) and trimeric autotransporters (TAAs). So far, the ESPR is present only in Gram-negative bacterial proteins originating from the classes Beta- and Gamma-proteobacteria. ESPR severely impairs inner membrane translocation, suggesting that it adopts a particular conformation or it interacts with a cytoplasmic or inner membrane co-factor, prior to exportation. Deletion of ESPR causes mis-folding of the TAAs passenger domain in the periplasm , substantially impairing its translocation across the outer membrane [3].	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.46	0.72	-6.70	0.72	-4.30	290	2495	2010-07-21 16:49:15	2010-07-21 17:49:15	1	530	854	0	281	2182	23	24.40	44	1.62	CHANGED	MN.+.lY+llWNcspss......alsVSE....l..u+	.....MN.K.lY+llWNcspus......alVsSE....l...A+........	0	52	130	207
+12860	PF13019	Telomere_Sde2	Ubiquitin-like;	Telomere stability and silencing	Wood V, Coggill P	pcc	Pfam-B_2457 (release 24.0)	Domain	Sde2 has been identified in fission yeast as an important factor in telomere formation and maintenance. This is a more N-terminal domain on these nuclear proteins, and is essential for telomeric silencing and genomic stability.	26.40	16.00	26.60	16.00	26.30	15.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.01	0.71	-4.55	20	270	2012-10-03 10:59:06	2010-07-21 17:50:03	1	9	236	0	202	1794	27	145.00	31	39.30	CHANGED	lNVLlooFsGhsLPsTLulsLPsooolo-Lhcclss+lPtohsp.....hhLTTsSN+tl.sssssslSsLlussss............shLsLRLss.LpGGKGGFGSQLR.AAGGRMSS++KpN..t-sNuSsRNLDGRRLRTVsEAKALAEYLAlKPEM-..........+K-KEtRR..................cRWcslVctsE+	.........................................................................................................................................................................hhshpLthR...LpGG..KG...GFGShLR.AhGuph...cKosN.......p-uC...RDL.s.GRRLRsVNctKtltE.altppsEc-..............+c...p+.ct....c.+..................pphcth.t.................................................................................	0	73	113	166
+12861	PF13020	DUF3883		Domain of unknown function (DUF3883)	Mistry J	jm14	Jackhmmer:O25123	Family	This is a domain is uncharacterised.  It is found on restriction endonucleases.	22.10	22.10	22.20	22.10	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.28	0.72	-4.25	140	729	2012-10-11 20:44:46	2010-07-22 11:22:32	1	17	639	0	217	541	130	96.80	24	14.27	CHANGED	sEphshphhhpt.ppt.........s.............ahsccs.t.........ps...hGYDItuh...........p..........sGp......p+a..IEVKupt............tttssht.lopNEhthAp..pps-..pYhLhhVhss.........ssps....phhhl	......................................hEphshphhpph.ptp.................s........................hphscspt..........pG.tGYDlhuh.........s...............psp....................pha..IEVKupp..........ptpsshh.lotsEhthup......ph..p..p..cYhlhhVhsh...scts..ph...h..........................	0	88	154	191
+12862	PF13021	DUF3885		Domain of unknown function (DUF3885)	Mistry J, Aldam G	gba	Pfam-B_1173 (release 24.0)	Family	A putative Rac prophage DNA binding protein. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YDDRG sequence motif. There is a single completely conserved residue D that may be functionally important.	21.80	21.80	22.40	24.00	21.10	21.30	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.82	0.72	-4.25	21	280	2010-07-22 13:00:10	2010-07-22 14:00:10	1	2	244	0	30	151	2	37.40	48	20.14	CHANGED	hHlYDDRGsDllusspcpLpsLYccascWILD..YDRpcI	.aHlYDDRGh-lhssNsEshtchhcKYpDhI.-.aDpEcI.......	0	9	21	26
+12863	PF13022	HTH_Tnp_1_2		Helix-turn-helix of insertion element transposase	Coggill P	pcc	pdb_2ao9	Domain	This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.96	0.71	-4.39	4	30	2012-10-04 14:01:12	2010-07-22 14:02:37	1	1	29	9	7	63	4	133.90	38	93.68	CHANGED	Mu+.hKpLEupLohcQRcAA.LLVtN...ELh.Ess.EKKTQ-ElApELGlsRhsLacWRTQspsFIsYhNhlADchLup+RspVYsQLM+hIpGsQ...PSVKAlDLFM+RaGLLTDKpVIE...Dsssssp+ost-IcpElscLsALl...K.c	...................Mu+.hccLctpLThpQhpAA.lLspN.....Elh.ps...s..cK+..TQ-ElApElGlsRoTLac.W.Rs.cNpsF.I.sa.p...s...clADshLup+RppV.....YspLh.phIhGsQ.......PSVKAhpLah.pRaGLLTD+.p.llc......sc.hssus+oN.t-IccplpcLpclht..c..........................................................	0	3	4	4
+12864	PF13023	HD_3		HD domain	Mistry J	jm14	Jackhmmer:O25415	Domain	HD domains are metal dependent phosphohydrolases.	21.60	21.60	21.60	21.60	21.40	21.50	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.12	0.71	-4.50	143	2536	2012-10-01 20:28:14	2010-07-22 14:13:12	1	13	2105	12	718	2045	280	160.20	26	71.76	CHANGED	h-+LKplhRpshhtss.p.RtEssAEHoW+lAlhuhlluths..s....ttlDhs+slpMh...LlHDlsEl.sGDhhshs....t.hsptt....pptcEppAtc+lash....LPps......tu.........pchtsLWp..............EFEs.......spos-A+a.............A+slD+hpPlltshtspspshtth.plphsphhsp.sptltps.tspla	....................h.s+LKhhpR..Wsh.....h.t...p........p...s...EsluEHohplAh....hA....h...h....l....s....t...hh.....s...........pl.s..h...p...+l...h.hhs.............lhHDhsEsl.sGDlssss.....................s...h...tpp......h...c...t...hE..p.t.A...pc.lh.sh.....lPpp..............hp.............................cpht.s.L.hp..............................Eapt............tps...-.u.ph............................s+thDtlpshl...ps...h.p.t.t..ts...tth...ht.t...................hh..............................................................................	0	211	416	587
+12865	PF13024	DUF3884		Protein of unknown function (DUF3884)	Mistry J, Aldam G	gba	Pfam-B_1352 (release 24.0)	Family	This family of proteins is functionally uncharacterised. However several proteins are annotated as Tagatose 1,6-diphosphate aldolase, but evidence to support this could not be found. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 106 amino acids in length. There are two completely conserved residues (Y and F) that may be functionally important.	21.70	21.70	22.20	22.00	20.20	17.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.88	0.72	-4.57	12	338	2010-07-22 13:17:09	2010-07-22 14:17:09	1	1	312	0	12	116	0	66.60	42	86.39	CHANGED	lacpVYllsFpchsp..phss..cLppLGcWhssoGppWhCHS...cLshs-FcptFhp..pLsssphthhpht.sahPap	........lY.lpF.chs....hsu..ccLKpLGcWhsoTG+.WhCHS...chph-EFKphFLp..hlss-chch.s.sssah.hp.......	0	1	3	7
+12866	PF13025	DUF3886		Protein of unknown function (DUF3886)	Mistry J, ALdam G	gba	Pfam-B_1536 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved L residues that may be functionally important.	25.00	25.00	31.80	31.10	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.50	0.72	-4.01	17	157	2010-07-22 13:20:39	2010-07-22 14:20:39	1	1	157	0	25	101	0	70.30	53	82.87	CHANGED	p......ptppcthoLKDtLss-lhtpLKttKcpLctcEpcRccccctc+tccp+c+EK..sKSFEELLsESpL.DW+c	...............QsccEslTLuDpLN-sLhppLKsKK+ELpscEE+KcAsEhcR+RpEpKEREK..NKSFEELLsESsL.sWKc..........	0	6	15	17
+12867	PF13026	DUF3887		Protein of unknown function (DUF3887)	Aldam G, Mistry J	gba	Pfam-B_1534 (release 24.0)	Family	This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 128 and 167 amino acids in length. The proteins in this family contain an N-terminal lipid attachment site.	24.50	24.10	24.60	24.20	23.10	23.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.40	0.72	-3.73	5	144	2010-07-22 13:28:10	2010-07-22 14:28:10	1	1	102	0	6	78	0	101.00	50	66.99	CHANGED	KEsKEcVcQSAE-pEsM...+sY+-VHcK.YDpKMNKELNpulpLaEpAKEKGGKsIspssaKEDVQKITsSMLEDID...HlRTEIRVPKSKEQEHclYlGFLNEoEQA	...KpsKEKVcpusEps.-h...+cY+tVHEK.aD..KMscpls.....hEsuKEKsucpIspAs.hhE-lpKl.Ts.shlEDhD......c.lpptIpVsK...cEpc+plhluFhsEsEpA...	0	1	4	4
+12868	PF13027	DUF3888		Protein of unknown function (DUF3888)	Mistry J, Aldam G	gba	Pfam-B_1080 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 111 and 149 amino acids in length.	22.20	21.80	22.20	21.80	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.76	0.72	-4.13	23	254	2010-07-22 13:30:48	2010-07-22 14:30:48	1	3	127	0	20	172	0	85.40	40	59.20	CHANGED	hpDslhshLtP.IscslpcaYuc........h.a..ppscllclc+hts.spa...Fhlslclpsa.....Gs+ssshupDplThpls.....stscllcacHhc	.....hEsALhshLashIppslEcQYt.........h.a..pCsclI...slK+lh.p.spal..Fplolphpsap....GspsPP.-KVTlThpsp......sclclpKlppc....	0	4	15	16
+12869	PF13028	DUF3889		Protein of unknown function (DUF3889)	Mistry J, Aldam G	gba	Pfam-B_1146 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (A and Y) that may be functionally important.	25.00	25.00	46.20	45.40	23.20	17.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.09	0.72	-4.33	19	153	2010-07-22 13:45:40	2010-07-22 14:45:40	1	3	127	0	20	104	0	96.20	45	78.51	CHANGED	llhshhhsh.hstsuhspsp...sshuKWt+lAhpcsKc+YPtAcllDYhalGRpptssp.oh-pF+lhL+cssK-FGVaVclpFcshTp+lhpIsl.Ep	..............lLhhsosushhsssulVcAp...PsYAKWGKLAVcKTKEpYPcA-IlDYLHlGR+s+TsphTVEKFKLWLREcGKEaGVFV-VpF-opT-KhIKloap+...	0	6	11	14
+12870	PF13029	DUF3890		Domain of unknown function (DUF3890)	Mistry J, Aldam G	gba	Pfam-B_1148 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 70 amino acids in length.	22.80	22.80	24.40	26.40	21.00	19.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.24	0.72	-3.93	6	114	2010-07-22 13:48:49	2010-07-22 14:48:49	1	1	28	0	9	75	0	76.90	64	51.96	CHANGED	Mspppsss-s.................lsclYpcIltLLslsccclSFpcFp.ahpLLEhIL.oRGIslpsLNhSphhLLlYYaI	..MSEQKsLQsQltuEEE.............LLVTKLHSEVLLLLGIDchALSRQNFLLHLSLLQAILVTRGIDASSLTYEQIFLLTFYHM.	0	6	6	6
+12871	PF13030	DUF3891		Protein of unknown function (DUF3891)	Aldam G, Mistry J	gba	Pfam-B_1216 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 250 amino acids in length.	21.40	21.40	21.40	21.90	21.20	19.60	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.36	0.70	-4.87	29	151	2010-07-22 13:55:02	2010-07-22 14:55:02	1	2	146	0	32	130	3	223.80	44	89.22	CHANGED	MIlp....pptp.sahlIpQpsHuhluGplAtpWpps.hts.sphhtpslhAltpHDcGWhch-..tsPhls.....psutPhsFhchP...sph+lthappulspstpps.YuuLLsShHhstlhpppt...............spphppFlspphp+............QcplhpsLs..................hp........pt.hcppYtLLphsDpLSLhlChsc.....Puspctt-lshhtsu...........tpphpsp.tsssplplsPaPFppc.hslslph+tlspp	........MIhR....Ecs-.c.lLIcQHDHGaLAGEIA++h+-chF..........Es.c..........sahcETlsAIYEHDRGWIELD..+sPILND....ucshPYTFhDsP...........oslRhlFYolGLsEl.EssNPYuALLCS+HahSFshNc-.........................D-EhhuFaptEL-RQKRlLpsLo..................................p-........phshhD+HY+LL+FCD-LSLYVCMNc.........PGscKcpEIslFK-GFctoc...hssppcc.lpAcWlD-pTI+IoPFPFps-.FpshV+YKslsK........	0	13	26	28
+12872	PF13031	DUF3892		Protein of unknown function (DUF3892)	Aldam G, Mistry J	gba	Pfam-B_1252 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 87 and 104 amino acids in length.	22.30	22.30	22.30	23.60	22.10	20.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.94	0.72	-3.58	62	309	2010-07-22 13:57:37	2010-07-22 14:57:37	1	1	292	0	68	216	6	75.70	33	78.93	CHANGED	plsslp+ss.tus....Isplt......hssspth...ohppslphlcs..G..............thssVtVh.......tspsG.pcYl+op..sDuspssNL.sL...P	..............................pIssl+Kss..cGs....lhthp......tssGpph...sh.pulp.hcs.G.....................plstVsVh.........p+pG.pcalRop..sDGtppsNLtsLP.............	0	27	50	58
+12873	PF13032	DUF3893		Domain of unknown function (DUF3893)	Aldam G, Mistry J	gba	Pfam-B_1590 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 123 and 144 amino acids in length. There is a single completely conserved residue E that may be functionally important.	22.10	22.10	22.10	22.80	21.70	21.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.97	0.71	-4.06	15	111	2010-07-22 14:00:18	2010-07-22 15:00:18	1	2	106	0	18	96	1	127.70	47	17.45	CHANGED	lIRINss.....-VPsahsh-..p-pshsps....GLat.........cppslYYSsGphshstss.....p........................hhpppllEIlslGs..c.pcEt-plAchl...Hhhp..pushhhpcslphPhPhHhsKh.lKcYlss..Dshthcp.--p.c.-h	............................................lRI..Nsu....FDVPpYGVIE.....sD.....-sLDss................uLYh..........DQKGMYYSTGEYS...hNsSt...............................................hhp+YILEIhPLGV.............K.sVERsYIAKMl...HYMC.CNS.SMLhcKN..lHMPYsMHMAKV.IKsYhTD.IDAREFKEFDDELDVDl.............	1	1	13	16
+12874	PF13033	DUF3894		Protein of unknown function (DUF3894)	Mistry J, Aldam G	gba	Pfam-B_1594 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 79 amino acids in length. There are two conserved sequence motifs: FNIC and MALLNLT.	25.00	25.00	67.90	67.90	20.90	18.00	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.92	0.72	-3.96	3	82	2010-07-22 14:03:13	2010-07-22 15:03:13	1	1	82	0	3	25	0	52.10	94	74.74	CHANGED	LATFNICSYLVAIVCMALLNLTFVlGAFQQKQYTSFVhALhM.FSFSIVAIlLl	LATFNICSYLVAIVCMALLNLTFVIGAFQQKQYTSFVIALVMSFSFSIVAIVLY....	0	0	1	1
+12875	PF13034	DUF3895		Protein of unknown function (DUF3895)	Mistry J, Aldam G	gba	Pfam-B_1598 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two completely conserved residues (Y and L) that may be functionally important.	25.00	25.00	25.30	30.80	20.40	24.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.47	0.72	-4.50	11	104	2010-07-22 14:05:47	2010-07-22 15:05:47	1	2	87	0	5	53	0	76.10	69	54.50	CHANGED	L.sphppchlp.alpsp.....ptIoAp-lCEhLIcpsussscpYoTsKsKIYs.VC.aL-aLspcGhlhhlcshshpDRlYtp	...........LSPLQKDILE..LlsS.....EEISALELCEpLIRuGKIsDERFTTNKPKAYGQVCLlLEGFV+EGKLIFVKsDEKRDRVYK.L...............	0	0	3	4
+12876	PF13035	DUF3896		Protein of unknown function (DUF3896)	Mistry J, Aldam G	gba	Pfam-B_1603 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	122.80	122.60	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.15	0.72	-3.92	5	83	2010-07-22 14:08:07	2010-07-22 15:08:07	1	1	83	0	3	28	0	61.00	84	96.53	CHANGED	MK+TYDYsATKKHLELKKQpLCKKLSNh+LSEKEREQIKhEIDNYEYILNLVEMNHYERGF	MK.TYDYsATKKaLE.KKQQLCpKLssh+LScKEREQlKhEIDNYEYILNlVEMNHYERGF	0	0	1	1
+12877	PF13036	DUF3897		Protein of unknown function (DUF3897)	Mistry J	jm14	Jackhmmer:O25995	Family	This is a bacterial family of uncharacterised proteins.   Some of the proteins in this family are annotated as putative lipoproteins.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.84	0.71	-4.66	74	1082	2012-10-01 20:48:06	2010-07-22 15:45:39	1	3	1047	0	176	569	152	184.90	36	90.44	CHANGED	hhhsul...hluGC.............us.s.sphh-..s...............sss.shosshssp........DhphsApcMspshlssPhltphhtpss.t..sl..lhlss..lpNcTsp.pIso..cphssplpptLhpo..G+hph.....ssssphs.shppphp.pppsuhhspsostthGp.luApahLpGplssh..lc...pstpp.hhYphshpLhslpoGhllWsscppl	..............................................................hshAh...hLuGC...........................s...........s.....................sslsp.ssslppp...........s.tst..spchs.shhhpPh.VuphhtssGsp......sVlhV-s....V.pN+Tst..pl......ss.....schT..cs.lp.suL.tss...GKFsL.......Vusppls.hs+pQ.Lshpsp.D.uL.sspS....p....AIuhu.............+tVGA.pYsLYushSus....Vp......................................t.p....hpMpLM.lpTGcIlWoscssl................................................	0	49	94	138
+12878	PF13037	DUF3898		Domain of unknown function (DUF3898)	Mistry J, Aldam G	gba	Pfam-B_1179 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length. There are two conserved sequence motifs: DFG and FEKG.	25.00	25.00	40.70	40.50	17.50	15.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.75	0.72	-4.11	9	132	2010-07-22 15:16:23	2010-07-22 16:16:23	1	2	128	0	19	80	0	88.90	74	25.58	CHANGED	ElQEpaosEQVhEAoAtIlEppPElELKhKLschplKuhLADFG-olHlAKVNGRYVlLIEuDslpFEKGsSPVEFLKP-sLp-Vlc+Ipp	..EIMEQFSTEEVMEATAQIVEHAPEVELKLKADHISVKALLADFGDpIHIAKVNDRYVLMIEADTLTFEKGFSPIEFLKPDELQDVIERIEN.	0	6	12	13
+12879	PF13038	DUF3899		Domain of unknown function (DUF3899)	Mistry J, Aldam G	gba	Pfam-B_1174 (release 24.0)	Family	Putative Tryptophanyl-tRNA synthetase.	21.70	21.70	21.80	22.20	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.11	0.72	-3.83	37	490	2010-07-22 15:18:45	2010-07-22 16:18:45	1	2	484	0	38	179	2	87.20	36	73.50	CHANGED	hlNlhF.llullhlllGhhlhlhpsGh..FcshtauF++hppphtppp.tphhpp......p.....p.hhtshhhshhlss..hlhhlhslhltah	.....alNIhF.hluLhhhIhuhhlhlhQpGh..FDss.pauF+Rlph.........phppp.c.pc.Ipcs.......spc...........ch.phhlupa..hhslllhs....ILhhlholhlohh................	0	11	22	32
+12880	PF13039	DUF3900		Protein of unknown function (DUF3900)	Aldam G, Mistry J	gba	Pfam-B_1279 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 360 amino acids in length.	21.00	21.00	26.90	25.80	18.10	16.00	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.41	0.70	-4.83	8	130	2010-07-22 15:34:20	2010-07-22 16:34:20	1	2	127	0	19	78	0	246.30	79	69.68	CHANGED	DFTIpaLSFYVlpVEGcuEpssKpaKHaQTLDpspYEcSsLKDFLDGELtKIuKRKV-RHPKSEpsPTKIGRFlVEPGH-LDSNPNYNLFpRhRhAEThEsFp-tSEphV+oYLDTSAVRGGVFLVspA+L+KYaDDsFVFlhKCDFEpKVAsIoDpSTLI+cVEMAITTKNMKSIQYPYMPEEGMVEEuELKIHQuSHARYFEDFLKFVEYscSMPEIlKsQVhsMsp-HIt-Tap-pSEERppFEEslElW	.DFEINYLSFYVVQVEGKGEuVDKRYKHFQTLDAEEYEDSSLKEFLsGELLKISKRKVERHAKTEQAPTKIGRFIVEpGHELDSNPHYNLFNRIRFAETKENFKDMSEPLVYTYLDTSAVRGGVFLIAQAKLRKYFDDPFVFVMKCDFEPKVASISDESTLIRNVEMAITTKNMKSIQYPYMPEEGMVEsGELKIHQASHARYFEDFLKFVEYERSMPEIMKT.QVMDMVYDQIEDVFEE..GT.EEREQFDQAMEVW	0	6	12	13
+12881	PF13040	DUF3901		Protein of unknown function (DUF3901)	Misrty J, Aldam G	gba	Pfam-B_1316 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a single completely conserved residue L that may be functionally important.	25.00	25.00	43.40	43.40	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.92	0.72	-4.67	32	262	2010-07-22 15:36:13	2010-07-22 16:36:13	1	1	134	0	36	125	0	41.30	48	84.45	CHANGED	+K....p++.....hoFc-LVpENKcpLLsDpcth-cIEc+l-c+attp	..........R+.p+R......KSFcpLlpENKQpLLss+-shccIEERIEKRaph.......	0	8	23	26
+12882	PF13041	PPR_2		PPR repeat family 	Coggill P	pcc	Wood V	Repeat	This repeat has no known function. It is about 35 amino acids long and is found in up to 18 copies in some proteins.\	  The family appears to be greatly expanded in plants and fungi. The repeat has been called PPR [1].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.51	0.72	-3.99	436	33080	2012-10-11 20:01:03	2010-07-22 16:48:00	1	3913	396	0	23020	36618	476	49.20	26	28.42	CHANGED	P.....s....l....l...o.YNsllsu.hs..c.pu.c.h.....cc.Ahclap-Mp..c.p...G.h...p.Pss.hTYshLlpu.hCc	.......................shh.oasslIsu.hs.....c...p.....G...p..h...................cc...A.h.p..l.a....p....c..Mt.....p...p............G...l............p..P..sh..hTa.ss.llsu.hs...............................	0	2730	14486	19222
+12883	PF13042	DUF3902		Protein of unknown function (DUF3902)	Mistry J, Aldam G	gba	Pfam-B_1357 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a conserved LGI sequence motif.	25.00	25.00	92.50	92.40	20.40	20.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.24	0.71	-4.95	10	107	2010-07-22 15:54:01	2010-07-22 16:54:01	1	1	79	0	3	76	0	158.30	69	95.33	CHANGED	KuVLKsIlIShIFulsGhhhLLFsLh....hGsuDWlLsWlGVLMAYLSLahLIsLYs+sTYcKphsKlLlKosllSFshAVLGIhFGIlapLLssWSLolMhWYWLLlLlLaLhTIIoLVILVFVNppspsashlY+hLILLNlhLTLGPVLWPlhloIl.GNGM	......KSVLKSILISFVFSAVGMCWLLFlLF....+GDGDWLLSWlGVLMAYLSLYTLIDLYCKsTYDKKlsKhLIKTsVTSFSFuVLGISFsIIHELLTPWSLSLMVWYWLlMLlLFLTTIIoLV.LVFVNRKNHNFTssYRlLILLNlhLTLGPVLWPLLLoII.GNGM........	0	0	1	1
+12884	PF13043	DUF3903		Domain of unknown function (DUF3903)	Aldam G, Mistry J	gba	Pfam-B_1600 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.	25.00	25.00	51.40	88.80	22.50	21.70	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.48	0.72	-7.85	0.72	-4.45	4	84	2010-07-22 16:14:07	2010-07-22 17:14:07	1	1	84	0	3	25	0	40.00	89	61.79	CHANGED	hsATSphLAIpKVRsECKRRFGKoLLLQTEIpEElhhcQK	VPATTQLLAIEKVRAECKRRFGKsLLLQTEIKEEIVFEQK	0	0	1	1
+12885	PF13044	DUF3904		Protein of unknown function (DUF3904)	Mistry J, Aldam G	gba	Pfam-B_1386 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in viruses. Proteins in this family are typically between 437 and 448 amino acids in length.	25.00	25.00	190.40	190.30	16.50	16.30	hmmbuild  -o /dev/null HMM SEED	436	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.50	0.70	-6.06	2	198	2010-07-22 16:22:22	2010-07-22 17:22:22	1	1	2	0	0	189	0	398.50	96	99.09	CHANGED	LVLFLhKEVLCEPChC-NPTCLGlTIPpsGaVRSAPGGVLLTETITEpPtLsEWTTSRs+LE-ohW.sG-sKsGKVSQTLFEAIQGTQMENCAVKAVhDToFVNLT+pDlVLG+lKVS.FGG-pDISKCGRKGLKVFICGGTsGYVTRGCPPEEC+G+KGRMMuLEPTsDCGVEKGhTT-RIKTGhlDlsSCCTQHGCTKGIRVEVPSPVLVSuKCpEloFRVVPFHSVPD+LGFARTSSFTL+ANhsNpHGWSKYsFNLRuFPGEEFIKCCGFTLGlGGAWFQAYLNG.VQGDGAASA-DVKEKLNGIIDQINKsNhLLEGEIEAVRRIAYMNQASSLQNQVEIGLIGEYLNISSWLETpTLTKTEEGLMKsGWCpSssHCWCPPcsshlPTIGYVDsIKEVTGTSWWMVMIHYIIVGLIVlVlVVhGLKLWGCl	..................PChC-NPTCLGlTIPpsGaVRSAPGGVLLTETITEpPtLsEWTTSRsRLEDSsWpGGEVKSGKVSQTLFEAIQGTQMENCAVKAVFDTSFVNLTRHDVVLGRVKVSPFGGEHDISKCGRKGLKVFICGGTTGYVTRGCPPEECRGRKGRMMSLEPTADCGVEKGFTTERIKTGKVDLDSCCTQHGCTKGIRVEVPSPVLVSAKCNEISFRVVPFHSVPDRLGFARTSSFTLRAsLANQHGWSKYNF........N...........LR..........A...........FPGEEFIKCCGFTLGIGGAWFQAYLNGEVQGDGAASAEDVKEKLNGIIDQINKVNLLLEGEIEAVRRIAYMNQASSLQNQVEIGLIGEYLNISSWLETKTLTKTEEGLMKDGWCRSSNHCWCPPDTVGIPTIGYVDNIKEVTGTSWWMVMIHYIIVGLIVVVLVVLGLKLWGCI..	0	0	0	0
+12886	PF13045	DUF3905		Protein of unknown function (DUF3905)	Mistry J, Aldam G	gba	Pfam-B_1447 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	19.70	19.70	21.80	31.80	17.60	16.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.95	0.72	-4.21	7	99	2010-07-23 08:51:41	2010-07-23 09:51:41	1	1	99	0	10	51	0	82.80	83	71.87	CHANGED	csPhLDtThPHQIsh.PSFKGoGhphppPFVNpaGVVIGDSpYsS.NSPLppWSDEhDPulMAGDEWlHPTNDIGWpotENR-LL	.......QSPILDETLPHQMNF.PSFKGTGKpMQQPFVNQYDVVIGDSKYNSENSPLpNWSDEVDPAIMAGDEWIHPTNDIGWISEENQELL.............	0	4	7	8
+12887	PF13046	DUF3906		Protein of unknown function (DUF3906)	Mistry J, Aldam G	gba	Pfam-B_1532 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved EKK sequence motif.	25.00	25.00	51.20	51.00	18.80	17.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.20	0.72	-9.01	0.72	-4.36	5	108	2010-07-23 08:53:15	2010-07-23 09:53:15	1	1	108	0	10	48	0	64.00	72	94.54	CHANGED	MaLYRFEAsl.cschlsIVIlApsEEpAF+LAElELEKaaLKlPslpElSLaEKK+Is+GAGYVl	.MDLYRFEAVL.sNSIVPIV..VVApSEEQAFKhAEIELEKHFLPLPEVKEIuLFEKKKIRKuAAFVI...	0	1	4	5
+12888	PF13047	DUF3907		Protein of unknown function (DUF3907)	Mistry J, Aldam G	gba	Pfam-B_1274 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length. There is a conserved AYTG sequence motif.	20.30	20.30	20.80	145.50	19.80	20.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.88	0.71	-4.59	16	138	2010-07-23 08:55:27	2010-07-23 09:55:27	1	1	138	0	20	93	0	147.50	63	90.38	CHANGED	Qs-pstphLpcslpplpsaLNppTLspLhpEp.su-c..sYYcslLusLR+LLVFsE-Gh-uCtllLpppsFccsAAEKsLYclYHQCIpEFFpPKpDsWYEDSRuAYTG+suIcF+ppsPpulcpLhhSlEutFpphREEL-YYETDYpT	..QTEQVuhFLE-sIslIosYlNaHTLPSLLEEossGsE..pYYKGlLuohRRLLVFCEEGtDAChVLLsSQPFRKTAAEKsLYKIYHQVIAEFFSPKuDpWYENSRSAYTGKNSIVFQQTPPASlEpVM+SLEGKFQlMREELEYYETDYQT..	2	5	11	13
+12889	PF13048	DUF3908		Protein of unknown function (DUF3908)	Mistry J, Aldam G	gba	Pfam-B_1533 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 140 amino acids in length. There is a single completely conserved residue Y that may be functionally important.	22.90	22.80	22.90	22.80	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.84	0.71	-4.17	9	99	2012-10-04 14:01:12	2010-07-23 09:58:18	1	1	97	0	5	46	0	121.50	72	89.42	CHANGED	shpphcchltpsphhpppsh...clhchh+clp.hL-..pshphhYPKNlFss..scclElhhhhpDs.hhhI.hppppc.thphchhph-slpcsplcpp.s...tshpLplhFssst.pIhhsSht..Ds..pp.ah..asc	...................NMKTIEEWIAESNARcEEDF..GpVVEEMKEVCl..GLD...NATLIYTKNVFCF..GKKVEVhFFFQDH..VVI.GQEK-E.YlEIEKLKYDsITpSNLKT..N..DKNTTLELKFANGQ.SINLDSLN..DNYGTKNWL..FAR.............	1	2	3	3
+12890	PF13049	DUF3910		Protein of unknown function (DUF3910)	Mistry J, Aldam G	gba	Pfam-B_1539 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	21.50	21.50	22.00	72.10	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.13	0.72	-3.90	6	84	2010-07-23 09:00:14	2010-07-23 10:00:14	1	1	84	0	3	46	0	92.40	90	91.92	CHANGED	MNlQAKVDWIGTPKPYIYK.DDVTYDAToIDFSLppDDNRYKLIVLKHEpssHYKhVQYGlKPGSQKPFPIDIPFcpsMLPLlEpILpDPYVQA	MNVQAKVDWIGTPKPYIYK.DEVTYDATSIDFSLAGDDNRYKLIVLKSEcNTHYKhVQYGIKPGSQKPFPIDIPFEQNMLPIIEQILHDPYVQA.	0	0	1	1
+12891	PF13050	DUF3911		Protein of unknown function (DUF3911)	Mistry J, Aldam G	gba	Pfam-B_1540 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	20.20	20.20	22.30	40.20	18.00	17.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.47	0.72	-3.87	5	86	2010-07-23 09:01:18	2010-07-23 10:01:18	1	1	85	0	3	28	1	76.10	94	94.08	CHANGED	MACVQIKGTRQEVVEMLQLFDLMDTKGFCKFDNYVEVEPNsccHNNFTASIDIQSNssSAQDp.LNDQFVSQMLTGVY	MACVQIKGTRQEVVEMLQLFDLMDTKGFCKFDNYVEVEPNsKEHNNFIASIDIHSNTSSAQDT.LNDQFVSQMLTGVY	0	0	1	1
+12892	PF13051	DUF3912		Protein of unknown function (DUF3912)	Mistry J, Aldam G	gba	Pfam-B_1615 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	21.80	21.80	21.80	148.90	20.90	21.50	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.29	0.72	-4.23	5	84	2010-07-23 09:02:45	2010-07-23 10:02:45	1	1	84	0	2	28	0	68.00	93	90.32	CHANGED	NFDIVGQKAYIKDGPHRNRIGIVKKNEcQLESpFAIVIGEQsIDVELKDIVLVGVDVGQFHcWCEQNG	NFDIVGQKAYIKDGPHRNRIGIVKKNETKLcSQFAIVIGEQsIDVELKDIVLVGVDVGQFHKWCEQNG	0	0	1	1
+12893	PF13052	DUF3913		Protein of unknown function (DUF3913)	Mistry J, Aldam G	gba	Pfam-B_1619 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	28.80	106.80	18.30	17.20	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-8.76	0.72	-4.03	2	84	2010-07-23 09:04:03	2010-07-23 10:04:03	1	1	84	0	3	13	0	56.80	97	93.66	CHANGED	KIhFYEKTAQ.DDLLGIWDNVPTIPRIGEKVEILKTlRTVTDIKYlKpGNNF+VEIl	KIWFYEKTAQLDDLLGIWDNVPTIPRIGEKVEILKTVRTVTDIKYVKNGNNFRVEII	0	0	1	1
+12894	PF13053	DUF3914		Protein of unknown function (DUF3914)	Mistry J, ALdam G	gba	Pfam-B_1562 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two conserved sequence motifs: KFDIR and DLW.	25.00	25.00	42.10	41.60	21.30	16.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.34	0.72	-3.83	5	85	2010-07-23 09:05:22	2010-07-23 10:05:22	1	1	80	0	3	51	0	88.00	89	78.88	CHANGED	MQIGLNlHTluQsTKlTPlslE+NTpusssppuKEssND.sIKFDIRSSEKEhKQucHKFTELDLWKMLKDKGVPLWIILEMLpKFRKEKEp	MQIGSNIHTLSQPTKITPSNLEHNTISSTKLESKK.lND.PIKFDIRSSEKEMKQPEHKFNELDLWKMLKDKGVPLWIILEMLQKsRKEKE.A	0	0	1	1
+12895	PF13054	DUF3915		Protein of unknown function (DUF3915)	Mistry J, ALdam G	gba	Pfam-B_1549 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	25.00	25.00	146.30	145.90	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-11.07	0.71	-4.14	5	84	2010-07-23 09:06:43	2010-07-23 10:06:43	1	1	84	0	3	45	0	119.00	86	97.62	CHANGED	MFGSFGCCDNF..RDCHH.....HEREp..HR...hcREKERc..hcspRsAVCNVLANISIGTEISLLolKGNGTFRNVIFEGFCNGVALFSALsh.ssDKD...sNKDDKNNpNpN..+FTGILRVCP-DIVAI	MFGSFGCCDNF..RDCHH...........HEREp....cR...-HREKERE..V+PQQPAVCNVLASISVGTELSLLSl+GsGoFNNVIFEGFsNGVALFSALAR.NssD.KD......NNKDDKpN..QN..R..N..TFTGILRVCPTDIVAI	0	0	1	1
+12896	PF13055	DUF3917		Protein of unknown function (DUF3917)	Mistry J, Aldam G	gba	Pfam-B_1608 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	25.00	25.00	149.20	148.60	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.43	0.72	-3.73	4	84	2010-07-23 09:41:22	2010-07-23 10:41:22	1	1	84	0	3	28	0	71.00	95	82.96	CHANGED	MTLKQNGLKRFVPGSILAGIALITYVsSIFlESlSl-hSTShhFIGITLFAGSlMVLMVAGIIlFIHMNSE	MTLKQNGLKRFVPGSILAGIALITYVISIFIESVSVDMSTSLMFhGITLFAuSIMVLMVAGIILFIHMNSE	0	0	1	1
+12897	PF13056	DUF3918		Protein of unknown function (DUF3918)	Mistry J, Aldam G	gba	Pfam-B_1567 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two completely conserved residues (G and R) that may be functionally important.	21.30	21.30	21.70	21.30	20.90	18.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.60	0.72	-7.98	0.72	-4.64	11	120	2010-07-23 10:07:22	2010-07-23 11:07:22	1	1	120	0	13	31	1	42.20	66	98.98	CHANGED	MN+shTSLlAlGsGsAAYphAp+sDhMNsRsMKKhR+Rlh+hh	.MN.LRNSLIALGVGAAAYQYARKQDVFSKRNMKKARKMIKSYL	0	1	7	9
+12898	PF13057	DUF3919		Protein of unknown function (DUF3919)	Mistry J, Aldam G	gba	Pfam-B_1479 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 251 and 262 amino acids in length. There is a conserved YLNG sequence motif.	25.00	25.00	76.40	76.00	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.55	0.70	-11.43	0.70	-4.89	13	118	2010-07-23 10:09:05	2010-07-23 11:09:05	1	1	111	0	10	94	0	220.90	57	86.08	CHANGED	cDKpsVlpphspSIPsKlclhsc+WGchslsDcspLppIhshlcpIspspoptss....csss.sIsGslaYLNGcKcoFplushLplssphYuss.hsshIstL+shLlshhYoPssLssllssssclIlhcp.ppspclssssKphIhspIcph+ploDsc-lt+hlspppcs.hhHI+lYhcscpt........cscspsllsIDVY-s.YhVVQYhGDENGpshYhKGsLsslhhK	..NDKQsVLQRVNESLPsElKVRHEKWGEIVlTDEVRLHTIVSFFDRIpIpPs-s.......KsQEQVFTGEVTYLNGpKRTFAVGDLFQYGsshYGKNGtDPMISAhQTYLLSLYYTPERIuDFF.ASApDVlV....RQGDVhRshNLTHILDSIRYAKQITDYGEIQKLLQSQNEP.IAYITAYKTGK........+lKN-REDILTISVYPS.YFVVQYLGDNNGNVMYMKuSLAplFVK..............	0	3	8	8
+12899	PF13058	DUF3920		Protein of unknown function (DUF3920)	Mistry J, Aldam G	gba	Pfam-B_1595 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.	25.00	25.00	26.20	83.30	21.40	18.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.74	0.71	-4.32	3	86	2010-07-23 10:10:41	2010-07-23 11:10:41	1	1	86	0	5	41	0	125.50	85	87.16	CHANGED	VLDSE.LPWDlQRl+sDlFSLIEKpchPVIFCDTCDANpVLhsLGEEEEEFLFPlGGFYHKEKQhIFVCMWEpYEQVLKTLLHEFRHuMQHEp-VLYVGpEsYEERhIEKD..ARtFAERKlDEYtcRs	VLDSE.LPWDVK+LR-DLFSLIElC.KTPVIFCDTCDAN+VLLSLGEEEEEFLFPlGGFYHKEKQLIFVCMWEEYEQVLKTLLHEFRHAMQ.....HKp-lLYVGSEpYEERWIEKD..ARKFAERKLDEYKNRK..	0	1	3	3
+12900	PF13059	DUF3922		Protein of unknown function (DUF3992)	Mistry J, Aldam G	gba	Pfam-B_1628 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 87 and 98 amino acids in length.	25.00	25.00	161.50	161.30	19.40	18.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.80	0.72	-3.79	9	83	2010-07-23 10:11:49	2010-07-23 11:11:49	1	1	82	0	3	40	0	78.90	94	86.70	CHANGED	FGMDKSKKLG-YVNALQALCEQYNVETDKIAIIEATEEYYLFLVKQE-CYDVVKVETVDTNI-YYTKAYKISSFNHTAY	FGMDKSKKLGDYVNALQALCEQYNVETDKIAIlEATEEYYLFLVKQE-CYDVVKVETVDTNIDYYTKAYKISSFNHTAY.	0	0	2	2
+12901	PF13060	DUF3921		Protein of unknown function (DUF3921)	Mistry J, Aldam G	gba	Pfam-B_1624 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	29.40	120.80	21.80	19.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.23	0.72	-8.93	0.72	-4.09	3	83	2010-07-23 10:12:38	2010-07-23 11:12:38	1	1	81	0	3	28	0	57.70	95	91.77	CHANGED	MDGFQLSMIQKAIHRTYDELGKEIDLQGVlADEIQKAQEEYLSALSHETLIDKRYLKS	MDSFQLSMIQKAIHRTYDELGKElDSQGAIVDEIQKAQEEYLSALSHETAIDKRYLKS	0	0	1	1
+12902	PF13061	DUF3923		Protein of unknown function (DUF3923)	Mistry J, Aldam G	gba	Pfam-B_1586 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	26.60	26.20	22.10	20.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.00	0.72	-4.12	19	152	2010-07-23 10:14:53	2010-07-23 11:14:53	1	1	147	0	23	92	0	65.20	41	83.99	CHANGED	h+hahlsslhhlllFlhhuhhIahRcVDGuGlhQThph+hlslhlhslhhlllllhplIWhllh++	...ahsWWluNlhWlIlFshhAslIWlRcVDGAGVhQTsclK.IoLlVllIsallslhhQlIWLlIsh+...........	0	3	10	15
+12903	PF13062	DUF3924		Protein of unknown function (DUF3924)	Mistry J, Aldam G	gba	Pfam-B_1601 (release 24.0)	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	20.90	20.90	22.30	125.80	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.94	0.72	-4.10	2	84	2012-10-02 18:44:02	2010-07-23 11:16:03	1	1	84	0	3	14	0	62.00	96	96.87	CHANGED	MsTLTIELPp-hAEKLDLLKQsYpKKTGAoIS-S....TLISKEFlQtITPFDLQQal.tKE	MNTLTIELPKETAEKLDLLKQAYEKKTGASISESTLVQTLISKEFIQAITPFDLQQFIsGKE	0	0	1	1
+12904	PF13063	DUF3925		Protein of unknown function (DUF3925)	Mistry J, Aldam G	gba	Pfam-B_1644 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.	25.00	25.00	92.40	92.30	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.22	0.72	-3.94	2	82	2010-07-23 10:17:35	2010-07-23 11:17:35	1	1	81	0	4	27	0	65.50	95	94.02	CHANGED	MKTAQ+EhISNREFYFVLYMMLLaVhGWVhDVNGLFLSpYFsLAG.I.LPlVGGlVGhFlMSIsKE	MKTAQHETISNREFYFVLYMMLLYVhGWVIDVNGLFLSSYFNLAGEIMLPLVGGIVGLFVMSINK.Q	0	0	2	2
+12905	PF13064	DUF3927		Protein of unknown function (DUF3927)	Mistry J, Aldam G	gba	Pfam-B_1668 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 50 amino acids in length. There is a conserved SVL sequence motif. There is a single completely conserved residue D that may be functionally important.	18.60	18.60	19.80	21.50	16.30	18.10	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-8.12	0.72	-4.48	10	463	2010-07-23 10:19:14	2010-07-23 11:19:14	1	1	177	0	1	147	3	44.00	64	83.66	CHANGED	hchRLslAslLLFLVVhVDFTSRIMSVLADGsLVuulVllhWPllK	...........hKLpLhssslLLalsVMlDFTSRIMSVLADGsLVCGIVVLLWPllK..................	1	0	1	1
+12906	PF13065	DUF3928		Protein of unknown function (DUF3928)	Mistry J, Aldam G	gba	Pfam-B_1675 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	25.00	25.00	194.40	194.30	20.30	19.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-10.17	0.72	-3.70	6	81	2010-07-23 10:20:22	2010-07-23 11:20:22	1	1	81	0	3	16	0	95.00	97	97.76	CHANGED	MYTLKIVSDREAlYQFASYV+VVQGVEDVYVEVGEPLYEHPLMKFYVHIsIcETY-QpKALQEIARLVELGRFTYVHYRN-EIEcAFEAVKYESF	MYTLKIVSDREALYQFASYVRVVQGVEDVYVEVGEPLYEHPLMKFYVHIKLEETYEQHKALQEIARLVELGRFTYVHYRNDEIEEAFEAVKYESF	0	0	1	1
+12907	PF13066	DUF3929		Protein of unknown function (DUF3929)	Mistry J, Aldam G	gba	Pfam-B_1716 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length.	25.00	25.00	151.10	150.80	23.80	18.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.23	0.72	-4.20	3	81	2010-07-23 10:22:33	2010-07-23 11:22:33	1	1	80	0	4	17	0	65.00	97	95.14	CHANGED	MVYHLENGETIKDIKEFCYRDpGKMLERVAHRVMDN+EVTAIDKQGTIISIAC-DIVKVELDYIp	MVYHLENGETIKDVKEFCYRDQGKVLERVAHRVMDNREVTAIDKQGTIISIACEDIVKVELDYIT	0	0	2	2
+12908	PF13067	DUF3930		Protein of unknown function (DUF3930)	Mistry J, Aldam G	gba	Pfam-B_1721 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 51 and 67 amino acids in length.	25.00	25.00	63.80	58.90	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.38	0.72	-4.11	4	87	2010-07-23 10:23:47	2010-07-23 11:23:47	1	2	80	0	3	25	0	52.00	82	95.06	CHANGED	M.......p+ppcahaE......IhKhlFlFhpshslshsthhlVQhIhph	.MEYQYE....V....G....QTKEEFMHEDQWADSLIKWLFIFLIIVGIPYTAYVVVQFILSF.	0	0	2	2
+12909	PF13068	DUF3932		Protein of unknown function (DUF3932)	Mistry J, Aldam G	gba	Pfam-B_1731 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	173.90	173.80	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.78	0.72	-3.89	2	80	2010-07-23 10:52:45	2010-07-23 11:52:45	1	1	80	0	3	20	1	81.00	93	97.49	CHANGED	MKEsFRLQTDFSSSFDRWVSSFVSsaPsQLcWoTLKELIHEYTooHTNpolPpYISSuhTYYAQRlSTANNoEIlIapN.T	MKEsFRLQTDFSSSFDRWVSSFVSDHPAQLEWTTLKELIHEYTToHTNDoLPTYISSAlTYYAQRVSTsNNSEIVIFEN.T.	0	0	1	1
+12910	PF13069	DUF3933		Protein of unknown function (DUF3933)	Mistry J, Aldam G	gba	Pfam-B_1720 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	25.10	98.90	22.90	16.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.53	0.72	-4.27	4	81	2010-07-23 10:53:53	2010-07-23 11:53:53	1	1	81	0	3	24	0	52.50	93	95.15	CHANGED	MKQYVICQlIsGsKYLAAYAETKQEAIEKAELLGLRTGsRYlVITAEEA-GLp	.MKQYVICQIINGEKYLAAYAETKQEAIEKAELLGLRTGNRYhVITAEEAEGLT	0	0	1	1
+12911	PF13070	DUF3934		Protein of unknown function (DUF3934)	Mistry J, Aldam G	gba	Pfam-B_1719 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There are two conserved sequence motifs: GTG and SKG.	25.00	25.00	31.30	31.30	19.40	15.40	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.29	0.72	-3.73	5	100	2010-07-23 10:55:23	2010-07-23 11:55:23	1	1	99	0	10	25	0	41.50	85	88.81	CHANGED	MSKoK..sKuGTGpGTGKKGWNRWQuSAK+.KKuAKPY..pSKGT	..MSKTKAKPKKGVGQGTGSKGWNRWQSSAK..K..KKAAKPY..KSKGT......	0	2	6	6
+12912	PF13071	DUF3935		Protein of unknown function (DUF3935)	Mistry J, Aldam G	gba	Pfam-B_1715 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two conserved sequence motifs: FVF and LGV.	25.00	25.00	37.30	78.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.19	0.72	-3.59	3	83	2010-07-23 11:43:06	2010-07-23 12:43:06	1	1	83	0	3	36	0	70.70	95	76.27	CHANGED	MTRLKQIFGIhISFFVFWFSMLGVQM.FAEFLDI-SLKFluGKTEsARAFLFsYPaFIlFLl...ShYh.FlI	.MTRLKQVFGIIISFFVFWFSMLGVQM.FAEFLDIESLKFVAGKTEAARAFYSPYPFLIVFLIT..LLSLYF.FVI..	0	0	1	1
+12913	PF13072	DUF3936		Protein of unknown function (DUF3936)	Mistry J, Aldam G	gba	Pfam-B_1705 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved GKAW sequence motif. There is a single completely conserved residue G that may be functionally important.	21.80	21.80	21.80	29.00	21.20	21.70	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.70	0.72	-4.50	7	122	2010-07-23 11:44:47	2010-07-23 12:44:47	1	1	122	0	13	56	0	37.40	68	82.30	CHANGED	MKlahhscullLsGKAWEIRtKLKcYsppaphVp-Wls	MKVYILPNRVTLVGKAWQIRHKLKQYGKEYTTVQEWIT......	0	2	8	9
+12914	PF13073	DUF3937		Protein of unknown function (DUF3937)	Mistry J, Aldam G	gba	Pfam-B_1711 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	22.50	22.50	22.50	75.40	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.25	0.72	-4.09	7	81	2010-07-23 11:45:39	2010-07-23 12:45:39	1	1	73	0	3	31	0	72.30	81	90.49	CHANGED	MFpNKKLIRhGLoLFlhLslIsFTIuYFQoYLcSAssIcWllschW+TILlDAPcGILVlLGAIALY-FTKcs	.MFTNKKLIRFGLTLhVhLhlIsFTISYFQTYLESAAGIKWVIsEhW+TILLDsPEuILVILGAIALYDFTKET.	0	0	1	1
+12915	PF13074	DUF3938		Protein of unknown function (DUF3938)	Mistry J, Aldam G	gba	Pfam-B_1607 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.	25.00	25.00	209.70	209.20	24.40	19.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.36	0.72	-4.17	6	83	2010-07-23 11:46:34	2010-07-23 12:46:34	1	1	83	0	3	21	0	102.00	96	80.04	CHANGED	NlQLGEpIIFNGIEoLVSASILGGYIaFLFNPEENAQKTMLLTMIGIVGGCISYSMTNYTLPLQLSSAFFHGLWTWFIAFCLADVFNLLQDsEE-sGRpIES	.NTQLGENIIFNGIETLVSASILGGYIaFLFNPEENAQKTMLLTMIGIVGGCISYSMTNYTLPLQLSSAFFHGLWTWFIAFCLADVFNLLQDNEEENGRQIES.....	0	0	1	1
+12916	PF13075	DUF3939		Protein of unknown function (DUF3939)	Mistry J, Aldam G	gba	Pfam-B_1535 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.	21.30	21.30	21.90	21.40	20.90	19.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.70	0.71	-4.45	6	100	2010-07-23 11:48:02	2010-07-23 12:48:02	1	2	96	0	9	42	0	135.70	75	85.22	CHANGED	pcpt.ctlcVTlDEVR+AlpcatpshscGIshpsLlpsspcIDhctLtsaLGGhPcQhFYMS+ETaEIF...tEE+-lsh.lDhVQlAVDpYlp-ptchPlhpsspshpVshpKL..ptYLcEhPpa.sLYls-pphlVohcPcp	........F.+TGKEEREITKDELEQAMApFLEp.NANIVYTVLVNDDYTVNYDLLKPYLPAFPTNhFLITKETLEVFEHTEENLNLVKE.IDlVQKAVDQYVTEKEMFPIVEGS......ED......RLICGMKL..GPYLsRlLKR.DLYISEKHYLVSSKPDR.....	0	4	6	7
+12917	PF13076	DUF3940		Protein of unknown function (DUF3940)	Mistry J, Aldam G	gba	Pfam-B_1673 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 50 amino acids in length.	21.70	21.70	21.90	22.80	21.10	21.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.48	0.72	-4.41	29	195	2010-07-23 11:49:13	2010-07-23 12:49:13	1	1	129	0	24	102	0	37.80	50	66.79	CHANGED	pcKphLIppLIppGlaKtpc..RpLaEhohpELcc.Ycph	......+KcaLI-cLIssGlaKhcD..RQLYELSLpELE+EYcs.h.........	1	1	14	16
+12918	PF13077	DUF3909		Protein of unknown function (DUF3909)	Mistry J, Aldam G	gba 	Pfam-B_1537 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	25.00	25.00	211.60	211.50	20.00	18.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.59	0.72	-4.18	11	84	2010-07-23 11:57:32	2010-07-23 12:57:32	1	1	84	0	3	30	0	107.80	93	97.97	CHANGED	MDLQKFDtMIDAVQRATClpIN-KQKEAFKQKYDFEPpFEYGRDEKGHYVIRTSKKMLEEMEFYLALKYDRDGlDLYMcAEIDGlCHVSVSYSEDALHLQELFQFLEE	MDLQKFDEMIDsVQRATClQINEKQKEAFKQKYDFEPcFEYGRDEKGHYVIRTSKKMLEEMEFYLALKYDRDGVDLYMQAEIDGIhHVSlSYSEDALHLQELFQFLEE	0	0	1	1
+12919	PF13078	DUF3942		Protein of unknown function (DUF3942)	Mistry J, Aldam G	gba	Pfam-B_1722 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length.	25.00	25.00	99.80	99.70	21.30	19.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.67	0.71	-4.03	5	85	2010-07-23 12:01:07	2010-07-23 13:01:07	1	1	81	0	4	34	0	124.20	88	93.83	CHANGED	LDEFsp+VKEYL-sEK-EKIIK-GHRDVIFpYLYcLEscIGVV+NP-FsFFTSGcRSHIVlENlEFKTEVcsE+NIIEITKIVDpVA.TsLDTIIlQDGELFALGRNEKFTppILp-YLpEsFuEhL	R.FEFTTKlKEYLDDEKDEKIIKDGHRDIIFpYLYsLESEIGlhKNPNFTFFASGRRSHIVLENIEFKTEVNVKSNIIEITKIVDNVV.IPLDTIVAKDRELFALGRNEKFSVQILEQYLFDTFGEKL...	0	0	2	2
+12920	PF13079	DUF3916		Protein of unknown function (DUF3916)	Mistry J, Aldam G	gba	Pfam-B_1564 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length. There is a single completely conserved residue S that may be functionally important.	21.30	21.30	21.80	21.80	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.73	0.71	-4.55	14	109	2010-07-23 12:11:47	2010-07-23 13:11:47	1	1	107	0	11	80	1	146.20	59	82.08	CHANGED	hhcphptph.shPsshasstY..Wph+lPVstualpup+sspplKphClQsLlspAppLhphKsssppphRVsshIslssLasSpIllF..cs..-cYFcsFhsRss.chppWlsLsspcsltpcWsLplssshpphGapElhpDp-...s..tcpElWaIGE	................MIKRIEEHTKsFPSTFYND..EY..W.M.LPVSQsFI-S+KTPRKVKRLCIQTLlspsNHLIph.K.PoDTHTYRVVsLISIpNLWcSQIIlF..KN..-DYFHNFFNRss.EFQKWIhLSNElDFWETWtISIssohphL+FQElIYDED...t...EKEIWFIGE............	0	0	4	7
+12921	PF13080	DUF3926		Protein of unknown function (DUF3926)	Mistry J, Aldam G	gba	Pfam-B_1663 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 46 and 63 amino acids in length. There is a single completely conserved residue P that may be functionally important.	25.00	25.00	26.10	82.60	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.06	0.72	-8.23	0.72	-4.42	8	78	2010-07-23 12:15:49	2010-07-23 13:15:49	1	1	77	0	3	35	0	44.00	80	80.29	CHANGED	MpILcELPsPIQQSAKpMLNILQEELSSYspEpsQspsNLKsII	MHILEELPsPIQQSAKQhLNILQEELuuYPpEQsHHcsNLKNII	0	0	2	2
+12922	PF13081	DUF3941		Domain of unknown function (DUF3941)	Mistry J, Aldam G	gba	Pfam-B_1728 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 30 amino acids in length. There is a conserved YSK sequence motif.	25.00	25.00	28.70	43.80	23.80	24.00	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.99	0.72	-6.85	0.72	-3.95	5	93	2010-07-23 12:21:47	2010-07-23 13:21:47	1	1	93	0	8	35	0	24.00	82	47.55	CHANGED	RccKNpt+..cKNtQpGK+AYSKKTD	.RsQKNEQE..QKNIpQGKRAYSKKTD.	0	1	4	5
+12923	PF13082	DUF3931		Protein of unknown function (DUF3931)	Mistry J, Aldam G	gba	Pfam-B_1734 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	40.30	161.30	21.50	18.70	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.32	0.72	-4.11	4	82	2010-07-23 12:31:39	2010-07-23 13:31:39	1	1	82	0	3	10	0	66.00	98	78.64	CHANGED	MDNNEKKCNVISIDGKKKKS-TYSYPKLVVEsKTYEFSSFVLCGETPDGRRLVLTHMISTDEFAGF	MDNNEKKCNVISIDGKKKKSDTYSYPKLVVENKTYEFSSFVLCGETPDGRRLVLTHMISTDEFAGF	0	0	1	1
+12924	PF13083	KH_4		KH domain	Bateman A	agb	Jackhmmer:O25768	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.30	0.72	-4.34	211	3577	2012-10-02 00:34:43	2010-07-23 16:26:45	1	7	2027	3	775	2186	412	73.20	25	47.89	CHANGED	cch...l...cplhcsllpp...p...plplptp.....p.c.ppthlplpl.sspD.hGplIG+cG+slpAlphllsss.s.s+...p.s..p...c...h..plpl	.....................................thlpthlcsllst..s.c.....sl.p.lphp......psp..pttplpl.pl...s.s.p.D....hG+..lIG+pG+slpAlc.t.llpsss..s.+....t..s..p....p.h.hl.....................................	0	331	604	701
+12925	PF13084	DUF3943		Domain of unknown function (DUF3943)	Bateman A	agb	Jackhmmer:O25483	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.	27.00	27.00	27.90	81.00	22.90	21.70	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.20	0.72	-4.48	33	236	2010-07-23 16:14:36	2010-07-23 17:14:36	1	2	221	0	52	187	8	110.00	50	30.54	CHANGED	puhha................DsDsahhNhhuHPYtGuhYassARssGashapShhaohsuShh.WEhusEs..EhPSlpDllsTsluGhllGEhhac.huphl....tsutphhsppshu....hllsPhs	..................p.GPsWDcDpahhNhlhHPYFGulYYsAARpAGas.acShhYShshSThFWEYGlEAFsEVPSWQDlhlTPhhGullGEhhac.hpptI.....hssGGclhGS-hhGthslhhlsPl.G..............	0	21	33	45
+12926	PF13085	Fer2_3		2Fe-2S iron-sulfur cluster binding domain	Bateman A	agb	Jackhmmer:O25214	Domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.45	0.72	-4.23	52	5265	2012-10-02 17:47:23	2010-07-24 12:26:47	1	25	3727	84	1318	3398	2510	108.10	39	42.50	CHANGED	plclhRhss................................................................tt.psahpsaplshc..ptholL-sLptIcpp..........-ssluac..tuCppulCGoCuhhlNGcs......pLACpshlpshhpt...............................................lplpPL..spaPVl+DLlV........Dhsshhc	............................................................................................................................................................................hplaRasP....................................................................p.ss....pPphps.Y..pl...c...hp...pshhlLDuLh.hlKcp...........DssLoFR...pS.CR.E.GlCGSCuM.lNGps...........pLACpsh....lcshs.p..t...........................................................................................lp.lcPL...ssh.PVl+DLlV..DhopFh.t.....................................................................................	0	387	813	1105
+12927	PF13086	AAA_11		AAA domain	Bateman A	agb	Jackhmmer:O25195	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.79	0.70	-4.79	118	5668	2012-10-05 12:31:09	2010-07-24 13:20:17	1	234	1842	10	3094	6877	709	222.70	20	21.82	CHANGED	pLNpsQtpAl...ppslsppt......................hsLlpGP.............P.............GT........GKT...polstlltth...................................................................................................................................................................................tttsp+lLlsusSNsAVDpllp+...Lhp.................hph...............pllRlGpsp.........psslpphs....hpt.h.........................................................................................................................................................................httphtphppthpth.pthtt.ptth............ppllppupllhsThsuu.upthhpph..................pF-hlIlDEAuQ.............usEsssLlPl..hhu.............c+hlL...................lGD.pQLPPslhSp	.............................................................................................................................................................................................................................................................................................................................................................................................Q..uh...........h.h.t.............................h.l...G..P.............P.......................GT...............GKT...........h.hh..t..hh...h...................................................................................................................................................................................................................................................................................................................t..hl.hh..s.s..s......A.hs...hh.t...h.t...............................................................................................................h.h.R..hh..t.....................................h...........h...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..h...t..t...h......p.....l......l........h..s..T....h.....ss..........p............h.t.t..h..............................................................th..c..hl.l...lD..E.....A....uQ................................h...h..t.......p......s..hh...s...l.......hhs...........................pphl...l...................................lG...........D..pQLsPhh...................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	1106	1755	2545
+12928	PF13087	AAA_12		AAA domain	Bateman A	agb	Jackhmmer:O25195	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.41	0.71	-4.94	125	5685	2012-10-05 12:31:09	2010-07-25 09:30:25	1	268	2107	10	3041	5759	458	189.40	23	15.53	CHANGED	hspSLF-RLhptt.................ttshhLshQYRMHspItp...FsSphFYp...Gc....Lpsus......shtppph..............................................................h.tshtP.lhFhcs................................sssppppppt...............sShhN.sEAphlhpllppLhpptstt..................pcI..GlIoPYpuQlphl+phlp.........p..............................pht.t......................................lclsTVDuFQG+E+-lIIhSsVRo...............s......pps.......................................................s....lG.FLsDhRRlNVAlTRAKptLlllGssp	...........................................................................................................................................................ohh.hh............................................hhLphp.a.R.h.p...p.lhp...h...s.s.....p.hh.Y.p...........s.p.......L..sts..................phtp.t.........................................................................................................................................................................................s...hhh.hss........................................................ts......t..ttt...t...............................tuhhN...tE.u........p.h..l.h.p.....hl...p.t.hh....pt..thtt.................................ppl......u.l..l....o....P...Y..p..u..Q...h..p..h...l..p..ph..l..p..........p..................................................................................................................................t..h......t..t.................................................................................................lp..l.sT.V.-s...a..Q............GpE.p-.l.lll..S..h.....V..cs.........s..................tpt............................................................................................................................s........hG....F..l.......p....s.............c.....R........l....N..VAlo.RA+pt.lhllGs..p..........................................................	0	1103	1793	2543
+12929	PF13088	BNR_2		BNR repeat-like domain	Bateman A	agb	Jackhmmer:O25303	Domain	This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-12.30	0.70	-5.11	78	2868	2012-10-02 00:45:24	2010-07-25 11:16:42	1	108	1391	46	640	2427	442	267.90	18	47.16	CHANGED	Gp...LlAhWFu.........GscEG..ssDlsIhho......ppp.ss.....p.......W..ussthlssst......................................htshtNPllht...ts.supLhLF...atssssss...............tWh...........uhh......hpSsD.......sGt..o.Wotsp....cLssu..........hsGsl+s....................s....lhhp....sG.pllhP...s.pE.......tt....ashhlthosDsuts.........Wppsphh.................................ph.stlQPoll..ss.......u..plhhhhRs..tps............plhtotSpDsGpoW..ss.......sp..........hslPNss....Sulsuls.LtsG..phlLshN........................................................RssLsl.....th..........SpDt.GpsWp.thhsL-sss......................................................phSYPsllpssc......s..plal	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s...h..........................t....s..lh......h......h..................................................................................................................................................t..................hpSsD..................sG.p.....T.....Wotsp..................pls.t.....................hh.h..h...s..s.spu..............................................................................................l..hp.............sG..cllhs...................shtp..........................ttt........ps.h.h..h....hS...c..DpG.pT.........Wphu.pss.........................................................................................ph..sps...ps...s....l....s..s........G.....slh.h..h.....h...Rs....ss.....................phhh.u.tSpD..s.......Gt.....TW....st............................................sp................................h.s..h...s..s......s...............u..sh..p.....h.h..p.....h.t...ss.........phhlh.hs..........s.pt....................................................................Rt...h..s..l..th...............s..t..Ds...uh.....sW.....hh.....l...p..s......................................................................huYsshh..ss.................................................................................................................	0	246	392	511
+12930	PF13089	PP_kinase_N		Polyphosphate kinase N-terminal domain	Bateman A	agb	Splitting PF02503 into domains	Domain	Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules.	21.90	21.90	21.90	21.90	21.80	21.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.49	0.72	-3.96	174	3094	2010-07-25 13:24:08	2010-07-25 14:24:08	1	9	2787	6	696	2356	835	105.30	41	15.31	CHANGED	hahNRELSWLpFNpRVLpEAtD.p.p.hPLLERl+FLuIhoSNLDEFFhVRVAuL+p...............plptuhsphs..sGho.............Ppcp.LptIpppspphhccptphapp.lhstLt.cpuIpllp	......alsRELSWLsFNpRVLppAtD.p.s.hP.....LLERh+FLuIaosNLDEFahVRVAuLKc...............plphu..h...pp....tu....ssu.h.s.............spc..LspIppcsp.chhpcp....tplas-.lhspLt.cp.sIhll.p.........................................	0	209	457	597
+12931	PF13090	PP_kinase_C		Polyphosphate kinase C-terminal domain	Bateman A	agb	Splitting PF02503 into domains	Domain	Polyphosphate kinase (Ppk) catalyses the formation of polyphosphate from ATP, with chain lengths of up to a thousand or more orthophosphate molecules. This C-terminal domain has a structure similar to phospholipase D.	23.90	23.90	23.90	24.70	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.90	0.70	-5.85	174	3665	2012-10-02 13:01:53	2010-07-25 14:32:09	1	10	2915	6	706	2979	1325	303.40	49	47.92	CHANGED	slFssIcc.pDlLLHHPYcSFssVlc.FlcpAApDPsVlAIK.TLYRsu.scSsIlpALlcAAcsGKpVTVlVELKARFDE-sNIpWA+pLEcAGs+VlYGlsGLKTHuKlsLlVR+..Ets.t.....l++YsHlGTGNYNspTA+lYTDhuLhTscpplupDlsclFshL.oGh...uc.s......phc+LhluPhsl+ppllchIccEhppActGc.sutIhhKhNSLsD.plIctLYcASpAGVcI-LIVRGICsL+PGlsGlSENIcVpSIVGRFLEHoRlahFtN.s...........G..........csclYluSADhMsRNLc+RVElhhPlhDspl+pclhch.LphhLpDNspuhtlpsDGsYpphps..p..........pp.h.suQphhhpth..p	......................................................................slFcuIRc.p.D.lLLHHPYcSFs.s.Vlc.hLcQAAtDPpVlAIK.TlYR.su...p.D.....S.IlpuLlcA...Acs.GKpVTVlVEL.p..A..RFD..E...EuNIpW.A.+cLEcAG.sHVla...G..hs..G...l....K.sHuKlhL.lsR+..E......ss....p..............lhcYsHlGTGNap...tTA+lYTD.hulhTss.plsp-spplFs...l..p.s........p..............................p....hp.....pL...hhu...P.sh+ptlhchIcpE.htt..t.p......tG....h......u........tIhhKhNsLsD.....tllctLYtASpuGVplcLll.R......Gh.CsL.hP..s.l.Gl.......S-....N....IclhSIl..sRaLE.HsRlahFts.s.................s..........................p.....plaluSADhMtRNlpp.RlEshhPlhs.plptplhp..hph.htDshpuh.lpt.-hp.thh.......t...........p.t..h.puQ.hhhp..h...........................................................................	0	212	466	607
+12932	PF13091	PLDc_2		PLD-like domain	Bateman A	agb	Jackhmmer:O26029	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.17	0.71	-4.38	205	18675	2012-10-02 13:01:53	2010-07-25 14:56:24	1	85	4401	14	4237	15098	1180	139.20	19	41.80	CHANGED	lhphlpp...up..cplpl.ssh..ah.............ppp.....l....hpsl.ht.ttp+G.lcl+llhsp..............................................p..h.thtthpthtph.hptshp..........h..........................................HsKhhll.D.......sp......................h.sh.l..GSsNhotpuh.........ptNh......Ehs......lhlp.sp........thspphpp..hF...pt...a	....................................................................................................................................................................h..phlpp..Ac.....cplhl.ts..ha.......................................s.spp....l........hpsL...hp....sspc.....G...V.......c..V..+..l..lhs.s..s...............................................................................................................h.....h.ts.hph.h.t.ph....h.p.s.Glc.lhhh..........................................................................tts..hhHpKhhll..D.......sp.........................................................................hsh.l...G.o..h.N....h.....s..s..c.uh...............thsh........................E.hs.............lh..lp...s............t.stthtt..h...........................................................	0	1240	2500	3500
+12933	PF13092	CENP-L		Kinetochore complex Sim4 subunit Fta1	Coggill P	pcc	Wood V	Family	CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2]. Fta1 is the equivalent component of the fission yeast Sim4 complex [1]. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.	21.70	21.70	21.90	22.10	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.85	0.71	-4.46	30	154	2010-07-26 14:40:08	2010-07-26 15:40:08	1	5	141	0	110	144	1	169.30	25	45.25	CHANGED	pshTpLPLLLsRhPssLRpshhoFLupsFDspsSsLRLsophLssshEpalsslspssss.....................plh+-hpLTLuFs.sssss.......................uL+olslsIPtpslssFhptu.....................................tt.psp.s....ssFhsuLusYhcpHLAhcLs.................tttl+LoKlusuuFllusEGRlKlluss	..............................................................................................phspLPLhLsphspshp.phlhsalppsFD...shho..sL....p....lsspsLshhhthahsshsppths..........................................phplhas.sstss.................................slpslsltIs.cchpshhpps......................................................t.s.t.p..pp.pps.....s.FhpsLtsahcc.Hhtlc.Ls.................................................................ss+Ls+lusushsht..s....-G+lKlhs..t..................................................	0	24	43	77
+12934	PF13093	FTA4	CENP-U;	Kinetochore complex Fta4 of Sim4 subunit, or CENP-50	Coggill P	pcc	Wood V	Family	Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1 [1].	24.80	24.20	24.80	24.80	23.50	23.00	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.38	0.70	-4.90	31	102	2010-07-26 14:45:24	2010-07-26 15:45:24	1	3	88	0	82	102	0	200.70	30	81.33	CHANGED	Msto.p.......olhplKpsFlcsQl...+ILSpsL.........pssccW+shst.ts.pp...............p.............Ls-.......+slpclLpKlNstL+pHsRtlaSsQAlpHVApQItpLYhpphtpsspp.sphpthlc.............................cssDLos...........ptsIppLPp......................................................................ph.t.....ps...ssppptp......................+YpcLppcLlpLsppppptpc+LsphppLpplL...........................EPacsspp........................slQsNLl.....o+supLspEl..p+MRhLls+Vuu+	.................................t......pl.phKpsFlpsQh...+lLSpsL.........tPsc..sW+shst..stpp.........................s........lsp.......+slpcsLt+lNthl.ppHsRtlassQAhp+VApQIppLYhpphpttst.p..p.t.hlp.............................ctsDLss...........tt.IppL.Pt.......................................................................ph.t............t.p.tptp......................+YtplhtcLhpLspp+pphpp+ltph+pLpphl...........................cPapsspp............................................slQ..NLl.....T+su.lttEl..p+MRhLlu+Vss+.........................................	0	14	40	68
+12935	PF13094	CENP-Q		CENP-Q, a CENPA-CAD centromere complex subunit	Coggill P	pcc	Wood V	Family	CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2]. Fta7 is the equivalent component of the fission yeast Sim4 complex [1].	28.50	28.50	31.00	29.90	27.80	28.20	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.05	0.71	-4.21	38	159	2010-07-26 14:57:46	2010-07-26 15:57:46	1	3	124	0	96	153	0	156.00	22	39.12	CHANGED	pLtp+Lsp.hshPsts...................pcs.hsh-plhpppptLEppLu....s.hcplphLppElccp-sthpp-tcpLpchccsscttcsphccppcp......+.lLpt.ppssspp..tsppp...............tp.ssph.................-p-ltsllpplp......pclcshpsstt.......lpslpctlpcspst.....Ls	................................plhpphtp.h.hPstp.........................................cs.hsh-pl.lptppsLEppls....ss.culthLpp....Elc.ctptphpppptplppLcpsspshppphccppcch..................+plhph....s...pp.ss.p..hsthsppp........................................sssh.................ppElhslhtplp......pchcshpsstp.......hpshhphlpcshttLp.......................	0	14	34	62
+12936	PF13095	FTA2		Kinetochore Sim4 complex subunit FTA2	Coggill P	pcc	Wood V	Family	Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1 [1]. The equivalent higher eukaryotic protein is CENP-P. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2].	20.70	20.70	21.40	21.40	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.49	0.70	-4.73	13	63	2010-07-26 15:12:01	2010-07-26 16:12:01	1	2	35	0	56	62	2	191.60	25	60.04	CHANGED	Ms...........................h.p.L.hspPscpss...............stPpLchFht...Hs..............psIphlpalstss-..........uhVaphclpu+.pYALKl...h..asapss..hh.cltt+th.......hahs...PhssEsRAauRLspltcpGhh....AV+CHGWhhLo..cpphpph................sp.hphhspWAIVKD...alssph........s.pplsplhpchplh+cshlhspDlp.pNYRsuhlVDLGssh	.................................th..................................tPpLt.F.h...pt..............tslphlphLststp..........uhVa+sclpup.....YALKl.............a....htts.....t...phttp.h.............h.ahs..................PFssEsRAauRLpchscpsh.....AV+CaGah..hLs....c...pphp.h....................................tpttphhshhAIVKD...hlssth..................p.psh.c.lhpchphh++htlhstDlpspsYh.suhllDhups.....................................................................	0	3	27	48
+12937	PF13096	CENP-P	ShortName;	CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P	Coggill P	pcc	Wood V	Family	CENP-P is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [2]. Fta7 is the equivalent component of the fission yeast Sim4 complex [1].	25.00	25.00	30.30	29.40	20.60	18.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.99	0.71	-4.96	5	51	2010-07-26 16:04:31	2010-07-26 17:04:31	1	1	35	0	27	49	0	127.20	51	60.61	CHANGED	Q+aRLuGsCpuLsFQLEFQlLElQsc-slssslTDLsIlhEssEapDLScFVSRsEEc+sLLLFFRSLpoFuEWCEaR+pTFcHFKEKYP-lVsLPEGspuEpMtlRNPQpPGhELlIVWKIHID-EG.sVlPlLDLLsKlPpQALELDcKuslEsuussFRoLLtlhGIEuoIEsLI	.....................+a+LSGsCp.lsFpLEFplLEh.psp-phSusloDLsIlhEssphuELScFloRsE-ctsLhhFFRuhp.asEWhcaRcpTF.HhKt.KYPphV.LscG.t.up.h.lpssp..sGFELhIVW+lplsE-G.pshPhLDLLsKhPppsLt.ppptsl-suP.tFRshlhhhGlEssl-pLI................	0	6	7	11
+12938	PF13097	CENP-U		CENP-A nucleosome associated complex (NAC) subunit	Coggill P	pcc	Wood V	Family	CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC [1]. FTA4 is the equivalent component of the fission yeast Sim4 complex. 	19.50	19.50	19.50	19.50	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.18	0.71	-4.33	9	57	2010-07-26 16:13:52	2010-07-26 17:13:52	1	2	39	0	30	56	0	158.90	39	44.36	CHANGED	p-s-spcpVtssEp.......pspp.pshssss....thsEcPupsVTsppsuspsupsSstctss.AspoppcTQK..p...t+Rp+scptsptocsu-shplW...C.cth+tS..DIpELDVlLutFE+hhLEY+QclEScsC+pAIscFasplKcpLhchlcElQhLKsLK+KNsKlluslEKKRQRL	........................................s-sppcltssc+......hsspppcsh.sss.......phsEcPupsVssppsus.ss..psssEcpsh.....s.pspp.....csQKp......p.t.s++p+s....c..opshs.scs..S-.......ssplW...C.cshKpS..DIpEL-lVLstFEKhhhEY+QplES+sC+pAIspFasshKEpllchlpEsQhLKNLKRKNAKllusIpKKRQRL....................	0	3	7	13
+12939	PF13098	Thioredoxin_2		Thioredoxin-like domain	Bateman A	agb	Jackhmmer:O25140	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.89	0.71	-3.87	144	3289	2012-10-03 14:45:55	2010-07-26 17:16:55	1	21	1889	26	693	17334	6561	121.70	21	46.68	CHANGED	s..p..s..p...s...Kh.hlhhF.ssss.Cs..aCcp..hc.pplhp..sp...ltth......h....................pt.p..hth.hhl................sh...................t.....psp................t.........hht.....................ttt...............h......tpp.......................p..........................................hu..pph.s..........lpu.TPsllh.hs.t.p........G........p.......p....hs.G.hh.s.s.p.phh.phL	.......................................................ts....p..t+h.hlhVF.s.D..ss.C.s.YC.+c....h.c....p...p.h.t.s........st.......l.s.h.t...h...............................................p.....t....hhh....h..h.l.....................................ss...............................................................................t.......s.s.p........p.......tt..t............hps..............................................tttp..................................t.......................................p...................................................................................................Ls...p.ph...G.............................l...s.u...TPsl...lh...s................G............p.........h.......hs..G..h....s..s..pph.th............................................................................................................................................................	0	189	415	577
+12940	PF13099	DUF3944		Domain of unknown function (DUF3944)	Mistry J	jm14	Jackhmmer:O26108	Domain	This short domain is sometimes found N terminal to Pfam:PF03981.	21.70	21.70	22.30	28.00	20.80	21.00	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.27	0.72	-7.32	0.72	-4.46	19	557	2010-07-27 11:58:35	2010-07-27 12:58:35	1	3	517	0	12	169	3	34.80	69	14.48	CHANGED	Y+.hDsDLEFLscCoscDLpsLVphLT+D.KDGphRh	..YL.pDsDLDFLQHCSEEQLAsFARLLTHN.EKGKsRL...	0	3	5	8
+12941	PF13100	OstA_2		OstA-like protein	Mistry J	jm14	Jackhmmer:O26089	Family	This is a family of OstA-like proteins that are related to  Pfam:PF03968.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-10.95	0.71	-4.90	30	372	2012-10-01 21:43:16	2010-07-27 14:41:27	1	9	305	0	104	461	481	129.20	26	25.21	CHANGED	Ko+VhL.HuDpLphDp.t.pPDAQlLhG...sVsh+HDushMaCDSAhhaEpoNSlEAFGNV+MpQGDTLhlYG-YLaYDGsTQlAhlR.cNVRMcN+ssTLhTDSLNYDRlhslGYYF-GGolsDpcNsLTScaGEYSPuTKhAlFspsV+LhNPcFsLsSD	...........................................................l...us.h.....hsp......s......s.....s.....h..h..G.....pVth..p.a.pu......hh..hsD....p...shh............p........p...p.....p..........hp...Ah..Gs.....V.p.....h......p....s..D.s.h...p.....lhu-hh.Yss..pp.s.hh....tp.V....h..h.h.p..p........t......p..L..h..s..-..pL.Ysph...p..h...uh......a.p.s.s..pl..h.s..p..t..s.hlh..u....p...G.Y..tsc...h..ts.h..p.t...................................................................................	0	41	89	102
+12942	PF13101	DUF3945		Protein of unknown function (DUF3945)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This is a C-terminal repeated region.	21.90	11.10	22.10	11.20	21.80	11.00	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.98	0.72	-8.53	0.72	-4.67	53	731	2010-07-27 21:34:35	2010-07-27 22:34:35	1	9	130	0	73	590	11	54.20	26	21.58	CHANGED	chhssalslDctTNclhsh.........ss....p.......lpIP.......sclps.lcLosppppsLppGcslhlc.hhspcs	.......................................hlphD..Ttph..h.........ht....p...................ltlP.......pclpG.lcLosppppsLppGcslhlcshhscp..........	0	26	64	72
+12943	PF13102	Phage_int_SAM_5	DUF3946;	Phage integrase SAM-like domain	Ellrott K, Bateman A	kellrott	JCSG - Joint Center for Structural Genomics	Domain	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. This family appears related to the N-terminal domain of phage integrases.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.17	60	914	2012-10-02 14:21:04	2010-07-27 22:57:47	1	2	196	1	136	888	67	145.40	17	38.17	CHANGED	lplRpKpL.ssGph.SLYLDhY...........suc.....RpaEaLplYlhsc.psttc.........................+cpNppslphAcsI+ucRhlElps.......pptsh.tspp.csctshl-ah...cphtcpppppsp.t........phpsshp.aLcpasttp.......lsFp-lDtcahpsFhcaLh	.............................................................................................................p.h.tpGph..slhl..chh..............................hptp..pph..h.t..lh.l..hsp..hstpp..........................................................pp.t.pp.h.h.t...ht.p..t..l.p.....t...p.chh.p.h.p............................tp.th...hp..p..t....ptp.......ts..hh....sah....cphhpphp....t.....p....s.p.......hp............papss...hp....p.....lppFhppp.........lshp-lshpalpsFcpaLh..........................	1	45	110	134
+12944	PF13103	TonB_2		TonB C terminal	Mistry J	jm14	Jackhmmer:O25752	Family	This family contains TonB members that are not captured by Pfam:PF03544.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.84	0.72	-3.94	102	1325	2012-10-03 21:09:15	2010-07-28 10:51:51	1	14	909	1	457	2915	858	85.30	19	30.22	CHANGED	hssYhspltptlpp.....p..W...s..st......ssshpshlplplss.sGp.l...shplhcsSGsptaDpuVtcAlp....pspshP..s....uth.....phthsF	........................................tahstltpplpp..........p.........a.....s.....ts............tstshp..s..plp......l..p........ls.s..sG.........p.l....h..s...s....pl...s.c.....o.S...G.....ssthD.....p.u.....shpulc........pssshP..s......tt......................................	0	136	268	371
+12945	PF13104	DUF3956		Protein of unknown function (DUF3956)	Aldam G, Mistry J	gba	Pfam-B_1228 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	22.20	22.20	23.90	93.00	20.90	19.80	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.12	0.72	-4.40	3	98	2010-07-28 10:22:01	2010-07-28 11:22:01	1	1	64	0	4	13	0	43.80	89	99.68	CHANGED	M..shssFVNGQPhLVVSVAGIEIARLEISLQVALTLIALGIPICA	..M-SCVlFVNGQPhLVlSVAGIEIARLElSLQVALsLhsLGIPICs.	1	0	2	2
+12946	PF13105	DUF3959		Protein of unknown function (DUF3959)	Aldam G, Mistry J	gba	Pfam-B_1424 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 260 amino acids in length.	25.00	25.00	25.40	25.30	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.67	0.70	-5.04	5	82	2010-07-28 10:32:12	2010-07-28 11:32:12	1	1	77	0	5	56	0	229.50	81	95.47	CHANGED	MLLSGLFPIAGIhKQIPLEQSLYIGGLLFFTSFGSYFAKKhYSRICSWIAYAPFITLLLlIWcQDITTuSlLANAKIAAC..IALlPsIaRFRTYGlTFGLlALWGALLWDlKEVQSLVILERMoSLMTScalYLLLLlGGLIlGGLLAshIHRKEKD-NKENINLapQKKKRK+LSFKI.LPRLPKL+MKLFKFGtK.oppK..c..+c+pYEEsh.....ch.pp.s.acpp..ol.GQTRMERRRN	..MLLSGLFPlAGlhKQIPLEQSlYIGGLLFFTSFGSYFAKKhYSRICSWIAYAPFITLLLVIWHQDISTSSIIANAKIAAC..lALIPCLFRFRTYGLThGLFuLWAALLWDhKEVQSLVILERMoSLMTSpahYIhLLlGGLIlGGLLAMhIHRKEKDsNKENINLFpQKKKRK+LSFKI.LPRLPKh+MKLFKFGGK.SKpKpPEKI+E+pYEEsss....TYEMpEQIc.YKE.s..slQGQTRMERRRN.............	0	0	3	3
+12947	PF13106	DUF3961		Domain of unknown function (DUF3961)	Aldam G, Mistry J	gba	Pfam-B_1483 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 40 amino acids in length.	25.00	25.00	63.10	63.00	21.50	19.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.95	0.72	-4.39	11	103	2010-07-28 10:37:55	2010-07-28 11:37:55	1	1	84	0	4	33	0	39.10	76	52.23	CHANGED	pslNcaFGI-tstSDpIWFYGhaululhlhhhsYllStll	.QSVNKFFGLD.TKEDCVWFYGFYGVAVSILLFMVFTSNIF..	0	0	2	2
+12948	PF13107	DUF3964		Protein of unknown function (DUF3964)	Aldam G, Mistry J	gba	Pfam-B_1516 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. There are two conserved sequence motifs: FYF and AFW.	21.60	21.60	24.10	179.00	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.39	0.72	-3.81	4	117	2010-07-28 10:39:55	2010-07-28 11:39:55	1	1	117	0	4	44	0	107.70	71	96.81	CHANGED	TRpEpIhpLsFFEDKPtLAEQIL+lE+cEplaLPsQFEIKQsssYphGEKpsllGRlcpFYFlul.to.Espa+hQAFssEhcs+tFFlsLssIpcp.lAFWhNplELl	.TRQERILQLPFFENKRELAEQVLKhEREEHlYLPDQFEIKQVPPYSFGEKpuIIGRIHEFYFlSl.GS.EusWKYQLFKDEMKCREFFVpLPsIsDQQIAFWFNNIELL.	0	1	2	2
+12949	PF13108	DUF3969		Protein of unknown function (DUF3969)	Aldam G, Mistry J	gba	Pfam-B_1576 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	25.00	25.00	40.40	40.30	20.10	19.60	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.15	0.72	-4.39	9	294	2010-07-28 10:43:29	2010-07-28 11:43:29	1	1	290	0	11	74	0	100.10	49	88.47	CHANGED	htspppl-pahhhhhlGhhpuh+hshIols.hEthlFp.hhhcllpchslcccLl-IItpGhpLEDl........t.lhspcLpcsIcslpspslphLhphp.php..cptlphl.	........htp...LEKhhLhhhhGlhppLKLtllSlDpAc+hlFs..hhEhLtshulccsllDLIHpGsELEDh.............tshshoIE-hlslCLQhhcEh.pphcsVEhp.c.l.l.............	0	5	6	8
+12950	PF13109	AsmA_1		AsmA-like C-terminal region	Coggill P	pcc	Jackhammer-O25308 (H pylori)	Family	This family is similar to the C-terminal of the AsmA protein of E. coli.	22.50	22.50	22.70	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.24	0.70	-5.06	21	213	2012-10-03 05:41:17	2010-07-28 11:44:00	1	5	211	0	30	230	477	212.80	47	23.87	CHANGED	splpssupacsGphsh.hppsp..lplc..ucshsD-FlNplhs.....p.phhptGpFsl..p...u.t.s.s.s.shapGclplpsThl+shphlpNlluFIcTIPSLlsF+sPsFsscGaplcpGpllFthpc-hLslcslpLpGsShDIhGpGhIsLcspplslsLpLpTlKshoshIsKIPlls....YIlLGK-tpISTslplpGsLDsPchpTplspDlLhuPFsllKRll	.........................................................................................s.tlchcushtNAphslh.h.sssc...LpLp....s.p.N.h.s.DpaLNp.hLQ.....K.puVps....GlFsLp......h..t.G....s..s....chF.......cG..pl..cF..p..NTalKDL+sls.p.LISFI..s..T..........lPSLL...........hF.KsP.........sFN.p.KG.lsl+cG+l..lFst..KK....D..lLulpsIsLsGsSlDIhGhGohsL+hNslDhsLELKTLKohScsISKlP..IlN....YlIL.G...Ks...p.c..I.S.T.N.l.+lcGolDcPKh+T...........plloDsLpsPFNllKpIl...............................	0	10	25	29
+12951	PF13110	DUF3966		Protein of unknown function (DUF3966)	Aldam G, Mistry J	gba	Pfam-B_1525 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 86 amino acids in length.	25.00	25.00	111.50	110.90	18.80	17.40	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.50	0.72	-4.16	2	85	2010-07-28 10:46:03	2010-07-28 11:46:03	1	1	84	0	4	20	0	49.80	97	63.60	CHANGED	VIhYISRKFSQERpLEKSEITAEL-MLscEsaKKQKIKEDHEtsHHLNsp	.VIVYISRKFSQERELEKSEITAELEMLADESYKKQKIKEDHEASHHLNAN	0	0	2	2
+12952	PF13111	DUF3962		Protein of unknown function (DUF3962)	Aldam G, Mistry J	gba	Pfam-B_1505 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 233 and 796 amino acids in length. There is a conserved FSY sequence motif.	25.00	25.00	25.30	32.70	24.30	23.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.56	0.70	-4.95	5	80	2010-07-28 10:48:59	2010-07-28 11:48:59	1	2	78	0	5	63	0	214.20	84	34.62	CHANGED	QLLAFKslV-PLhpEsVaYlYFPcEWlsLLctHh+sacLssKLKtLNERLYhMFSDILFIQHNPYsLsEsoPWIVuKEPl+QEQLEYIs+uWY..ElIH-WK...PschlsPscLEWQsshISNLPlLHDNcTaaKWIPALITHlFCEcPLHLslsNcs-EElhFsPLRSQ+lsEAMSEPI+DccTQDYFSYVYRFEsITRGGE.NtPLLKVSIGIRRFYQp	................................................+LLTFENIVEPLLNEpVSFIYFPIEWLDIVEIHYKTFLLTSKLKRLNERLYDMFSDILFIQHNPYVLNENTPWIVSKEPIRpEQLDYIFQSWY....EIIHDWK...PNKLIEsPKYEWpYDLISNLsVLHDpEs....YSKWVPALISHIFCERPlpLE..NhNEE-IYFSPLRSQNICEAMSEP.....I...KDEKTQDYFuYVaRFEhITRGGE.NIPLLNVSIGIRRFYQE.	0	0	2	3
+12953	PF13112	DUF3965		Protein of unknown function (DUF3965)	Aldam G, Mistry J	gba	Pfam-B_1524 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 380 amino acids in length.	20.10	20.10	20.50	21.20	18.90	19.50	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.01	0.70	-5.25	3	85	2010-07-28 10:52:17	2010-07-28 11:52:17	1	2	83	0	3	38	1	284.80	92	75.80	CHANGED	QEIGWYKEAYTFMVs+sLssFVHTSlEYETWDlLTQAVAWNYLIIKYRIGcLEDuDlhIWERIKFNEECIEcCcsLLSHKEVLEFTFFYlCKQAKpLSKEcLNp-MMsLAIYCNTYVYDLYoYDLL+KYRKCTDFLSYYGPSpuVLACQRAVlAQISDRLNPLKTTHVDDYLYVMKEMMEHMoapFMcRY-HFIGKLLSYVPFFEMIQVPQHAYYCEELMYICKGIuYKEEILRNYlFIQLHDCLPSFIKlFLKNKRYATIHDILFYWCDcEQRMuLERKYNLSFIYEKYA	.......QEIGWYEEANsFMlsQGLAEFVHTSLEYETWDLLTQAVALNYLIIKYRIGELTDtDVEIWDRVKFNEKCITDCKHLLSHKEVLEFTFFYMCKRAKSLSKEQLNSDMMSLAMYCNTFVYDLYTaDLLRKYRKCTDFLSYYGPSQAVLACQRAVLSQISDRLDPLKTTHVDDYLYVMK-MMEHMTIGlMDRYsHFIGKLLSYVPFFEMIQVPQHAYYCEELLYICKGIcYKEEILRNYIF...IQLHDCLPSFFKLFLK..NKRYATIHDILFYWCDDE..QRMSLEKKYNLSFIYEKYA............	0	0	1	1
+12954	PF13113	DUF3970		Protein of unknown function (DUF3970)	Aldam G, Mistry J	gba	Pfam-B_1596 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved NPKY sequence motif.	21.10	21.10	21.10	21.50	20.60	19.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.85	0.72	-4.28	7	111	2010-07-28 10:55:07	2010-07-28 11:55:07	1	1	110	0	11	35	0	61.30	65	99.96	CHANGED	Mhp..lRlpGpcE.EI.chlpshsc..taEloa...spcshttsNPKYchSKslhsYlclKh.....pK	MIR..VRIEGTEE.EMLEFMcKMPDIPGFEKTH...hREPR.KGNNPKYDSSKNVLAYLSYKKIE..VANK.	0	2	6	7
+12955	PF13114	RecO_N_2		RecO N terminal	Mistry J	jm14	Jackhmmer:O25605	Family	This entry contains members that are not captured by  Pfam:PF11967.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.08	0.72	-4.26	24	198	2012-10-03 20:18:03	2010-07-28 14:46:01	1	3	198	0	22	850	192	71.10	66	34.33	CHANGED	MQGaILpsp+V+DEDLIVplLTpsplhphY.....RFYGARH......SsIplGaKIDFElEpst.ph.ls+LRslhHLGatWh	..........MQGFIL+TQK..VK..DEDLIVaILSPctL..lKsY......RF.....YGh.RH.........................SoIhsGYKIDF..t..LEcss..sF..LPRLKDVLHLGFlWI........................................	0	6	19	22
+12956	PF13115	YtkA		YtkA-like	Coggill P	pcc	Jackhammer_O25884	Family	\N	24.40	24.40	24.40	24.60	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.28	0.72	-3.63	90	656	2012-10-01 19:30:51	2010-07-28 15:05:13	1	14	358	0	179	609	32	85.10	22	36.73	CHANGED	ptpsps......hplpls.ssp...ph....psGp.s.s..l...hs....t...ss...psGc..sVs.sA.s.l.phphhhst.t..uhtph.pshh...........p.spp...tsGhYphp.ssh.sh....sGpWplplp	.......................................tshplplt.ss......h....psGcs.s..h...pl...........p...hs...pssc......sVs.cA.p..V...p.hphhps........Ghtph.pths.......................p.spp...tsGhYpsc.tsh.sh....sGsaplplp...............	0	58	121	145
+12957	PF13116	DUF3971		Protein of unknown function	Coggill P	pcc	Jackhammer_O25308 (H.pylori)	Family	Some members of this family are related to the AsmA family proteins.	22.50	22.50	22.50	22.60	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.69	0.70	-5.03	104	1538	2012-10-03 05:41:17	2010-07-28 16:08:13	1	12	1521	0	320	1280	259	286.00	26	24.21	CHANGED	htssspshc.YhPt..hhhupsLpsaLssAlp.......u.GpspsuplhapGslsp.aPat.....ppp..G.FpshsslcsuphpFpss..........WPslpslshslhFpNsslthpsspupltsss.hssspssIscl.sppsh...LpIcuchsu.pspsltchhppoPLhsslu..tsL.stlplsGplsupL.pLsIPLp.....st.......tspGphsl.pssslhls....shplpslsGplpFs.s.......sslsupslpAphhspPlslshss........ppptpshtl.....slslpGph....phptl.t......hst.....ltt...hlsGpssapsslslths...........ptshphpl	....................................................................s.ssspshR.YhP......hhucs.LhcaLssAlp........u...Gpscs..uplh.....h.t...G...s....pt...F.....Pap..........tsp.....GpF..plh..s..sl..csupa.tapss...............................................................W.Pulpslsh-Lsa....s.ss.....L......hh.....p.....ss......pu..............p.....l......s.....s......l.....p.....s.o.......s......l.............s..ss.............I.P..Dh.sccp.......LhIcuc.....hpG...sups.l.tsh...h.s.p..o.P...L.t..s.hu..ssL.sth..p...l.s.Gs.ls.u..cL.cLsIPLp.....................st...s....sspG.plsL...psssL.lt...s...s......sLpslsGp.hpFs..s........sslpup..slp..AphhstP..lslc.hss...........pp.tsp.shps........tl.slsush.......ps.tth.s.........hls.t.......l.p...hlsGsssaphpltlt...............................................................................................................	0	70	171	243
+12958	PF13117	Cag12		Cag pathogenicity island protein Cag12	Mistry J	jm14	Jackhmmer:P97245	Family	This is a Proteobacterial family of Cag pathogenicity island proteins.	25.00	25.00	26.20	25.90	21.70	19.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.41	0.71	-4.17	13	185	2010-07-28 15:30:54	2010-07-28 16:30:54	1	2	135	0	10	136	1	109.40	36	56.11	CHANGED	hhhshlLsuC.SSsPcPscl-tsp.tlslNsplhppp.hshVPKss.hlss.sWsYplhlpsh..c-chlssc.hsphFhlAHsuc+IlllGptsphtpYKpahppNGspusIp..lQP	......h.lLsllLoAC.Ss.sc.s.h.pcs+shpsl.Np.Ll-p..aSplPhss..plpshsahhplhl.sa...cDhllcsc.hslpFtLsHpo++IsllGcusphhpYKsYhptNGApusI-..lQ...................	0	2	5	9
+12959	PF13118	DUF3972		Protein of unknown function (DUF3972) 	Mistry J	jm14	Jackhmmer:O25162	Family	This is a Proteobacterial family of unknown function.  Some of the proteins in this family are annotated as being kinesin-like proteins.	22.70	22.70	22.70	23.00	22.50	22.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.49	0.71	-4.05	47	197	2010-07-28 16:11:16	2010-07-28 17:11:16	1	3	197	0	21	106	3	123.20	63	65.04	CHANGED	EFs+LspLsc-hlhthhspGtLpsKp.EcGKlhI-AspGT.ulV.sstpshhuMspshshht.s..FVEKTIGTILNLHEKVLsAKDETlpAlKNENpFLKDALhSMQElY-ED+KTI-hLppEL+pAR	..................EFCKLVHLsE-VVcuMhssGsLshKE.E-GKIYIEAppGT.h.........SVVPuu..spshsuM.......s.........sShslsupS..FVEKTIGTILNLHEKVLDAKDETL-ALKNENKFLKDALYSMQELYDEDRKTIETLspELK+AR...	0	8	18	21
+12960	PF13119	DUF3973		Domain of unknown function (DUF3973)	Aldam G, Mistry J	gba	Pfam-B_1636 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved YCI sequence motif.	25.00	25.00	53.00	52.30	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-8.27	0.72	-4.03	3	87	2010-07-29 08:33:42	2010-07-29 09:33:42	1	1	86	0	4	44	0	41.00	92	51.35	CHANGED	MYYCIsCSEIHHEKusNDKVFKNGFYIDPFLGERYHLGMCK	MFYCINCSDIHHEKHPNDKVFKNGFYIDPFLGDRYHLGMCK.	0	0	2	2
+12961	PF13120	DUF3974		Domain of unknown function (DUF3974)	Aldam G, Mistry J	gba	Pfam-B_1643 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length.	25.00	25.00	38.30	38.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.86	0.71	-4.30	2	82	2010-07-29 08:38:48	2010-07-29 09:38:48	1	1	81	0	3	41	0	124.00	94	45.69	CHANGED	MuFIphVLLLlGTLLLIuFTlVVLlVYFGRKhYhSWsKPYKRAp-Sl-KLSNKShPFLQEFTQHPLFYRWIRTEGKKEQpshNTLFCsusQRTREQVFSMLPK-+QKKVHsMAKoTKKlTNE..DI	MSFIQTVLLLLGTLLLIAFTVVVLVVYFGRKLYFSWTKPYKRApDSL-KLSNKSlPFLQEFTQHPLFYRWIRTEGKKEQ+TLNTLFCASuQRTREQVFSMLPKEKQKKVHVMAKTTKKLTNEDIDV....	0	0	1	1
+12962	PF13121	DUF3976		Domain of unknown function (DUF3976)	Aldam G, Mistry J	gba	Pfam-B_1743 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 40 amino acids in length.	25.00	25.00	83.50	83.00	18.60	18.20	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.02	0.72	-4.11	3	82	2010-07-29 08:43:40	2010-07-29 09:43:40	1	1	82	0	3	20	0	40.00	94	67.13	CHANGED	MYLFVRKDITKDNTLTKRGFYKLIGCLVVMFIGIIVMIVLl	VFLFIRKDV.QGGTLTKRGFYKMIGCLVVMFIAIIVMIVLI	0	0	1	1
+12963	PF13122	DUF3977		Protein of unknown function (DUF3977)	Aldam G, Mistry J	gba	Pfam-B_1744 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	61.30	61.20	20.00	17.60	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.67	0.72	-4.17	4	85	2010-07-29 08:51:07	2010-07-29 09:51:07	1	1	85	0	2	40	0	76.40	87	91.52	CHANGED	MKYIEhGIGN+WhVRTETEpEDGTEFEQKGIlKPIYFESlYlRlWFRKTClIhDoKEGFKKh+KpRsEYKFIhGIVS	.MKYIEIGhGNRWFVRTETENKDGTEFEERGIIKPIYFESLYVRlWFRKTChIFDTKEGFKKVKKRRIEYKFIlGIVS	0	0	1	1
+12964	PF13123	DUF3978		Protein of unknown function (DUF3978)	Aldam G, Mistry J	gba	Pfam-B_1745 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.	25.00	25.00	27.00	26.70	19.00	17.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.72	0.71	-4.80	3	84	2010-07-29 08:52:49	2010-07-29 09:52:49	1	1	83	0	4	30	0	143.90	88	98.04	CHANGED	MEAYNMHNFINTNIESpPcETsFNLHICEoNEFDsNLTKSTTLSFIVTK+NIKIlTKKWINScpESMIGKSYIIPTKAFHYlLPIIsEoEEEMsIQVQSFGlsGELLLNERLLIcKNN+hNS.KIsuFFEALNENI+QALRTLQIp	.......MEAYKMHDFINTNVESHQNETVF.NLcICE.TsEFDVSLTKSTTLSFIVSKKNIKIVTKKWINSNQESMIGKSYIIPTKAFHYFLPIISETEDELNIQVQSFGLHGELLLNERLLIDKNNKHNu..KIToFFETLDENVNKsLRGLQI.H....	0	0	2	2
+12965	PF13124	DUF3963		Protein of unknown function (DUF3963)	Aldam G, Mistry J	gba	Pfam-B_1512 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 85 amino acids in length. There is a conserved DIQKW sequence motif.	25.00	25.00	84.10	84.10	18.40	17.50	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-7.98	0.72	-4.16	4	53	2010-07-29 08:58:40	2010-07-29 09:58:40	1	1	51	0	2	29	0	40.00	86	64.97	CHANGED	MlhINshFIERYFcDIQKWIRNIThCFALLVVsLVuLWIG	MLSIYTAFIEKYFcDIQKWIRNITFCFALLVVVLVALWIG.	0	0	1	1
+12966	PF13125	DUF3958		Protein of unknown function (DUF3958)	Aldam G, Mistry J	gba	Pfam-B_1404 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There are two conserved sequence motifs: RLF and TWH.	22.80	22.80	24.30	24.20	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.42	0.72	-4.11	9	95	2010-07-29 09:08:48	2010-07-29 10:08:48	1	1	45	0	3	73	0	92.20	64	82.10	CHANGED	VFEEQDRNQpAIQpQEpAEtDFaEh+sRssRLFsRILETWHsDKElSpFFhNhpQEuQaIERKLTFELENQKETLlKE+RcLpDLENDLoYppQpLt+E	...............................lFEEQscNp.AlQtQEpAEAsFaEW+sRspRLFsRILpTWHGD+EhspFFhNhhQEspplERKlTFELENpKETLLKE+RcLS-hENDLSYpQQ.QLtRE.......	0	0	0	1
+12967	PF13126	DUF3975		Protein of unknown function (DUF3975)	Aldam G, Mistry J	gba	Pfam-B_1736 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	25.00	25.00	43.10	43.00	18.90	18.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.04	0.72	-3.83	2	81	2010-07-29 09:50:29	2010-07-29 10:50:29	1	1	81	0	2	42	0	78.80	90	93.89	CHANGED	MWKEKGpQllshIhlGIVlLLQhSFHhIE.LFHKslSILTFhPNMsLEllSIVWSIIASIhIlIIW.....uIthLhpplhhKcS	MWKEKGKQlLAWITLGIVILLQISFHIIEWLFHKVlSILTFLPNMTLEhISIVWSIIASIAIVIIW.....SIAKLWNKLFKKDS	0	0	1	1
+12968	PF13127	DUF3955		Protein of unknown function (DUF3955)	Aldam G, Mistry J	gba	Pfam-B_966 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 68 and 87 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.	20.60	20.60	22.50	22.20	19.40	19.40	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.88	0.72	-4.43	30	317	2010-07-29 10:35:54	2010-07-29 11:35:54	1	6	248	0	29	152	36	61.90	33	75.10	CHANGED	hppahluhlhhl.lGlhChhhashhsShVsssGhLpEP.FaLIPlualhlhhu....llshlhshlp.ph	.......hpphhluhhhhl.hullhhhIpshs.ohlsssGhLcEP.hF...ahlPlGalhllhu....hhshlhshlpp.h........	0	13	21	25
+12969	PF13128	DUF3954		Protein of unknown function (DUF3954)	Aldam G, Mistry J	gba	Pfam-B_934 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length.	22.20	22.20	22.60	22.80	21.60	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.33	0.72	-4.54	12	144	2010-07-29 10:39:09	2010-07-29 11:39:09	1	1	89	0	4	82	0	48.70	54	84.47	CHANGED	MK+.EIshtpNtlYlV.pcGclphl.pPPpoGFGEQslhWpsGKVs+scsppT	......MKt.EIDlppNtIYlV.KNGpVphl.pPPtoGFGEQshsWpsGKVsRs-sphT..........	0	1	3	3
+12970	PF13129	DUF3953		Protein of unknown function (DUF3953)	Aldam G, Mistry J	gba	Pfam-B_875 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 76 amino acids in length.	21.80	21.80	21.80	22.10	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.76	0.72	-4.33	36	454	2010-07-29 10:41:40	2010-07-29 11:41:40	1	1	294	0	22	219	1	41.90	39	68.35	CHANGED	hhhhL...GhhhlhhGlp-h+...ccc....KshGhhshlsuhaslhVul.p	........hLL.GlhslpIGhpphK.....Kcc........KhhuIlshLAGshlllVulh.....	0	5	13	13
+12971	PF13130	DUF3952		Domain of unknown function (DUF3952)	Aldam G, Mistry J	gba	Pfam-B_704 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length. There is a conserved VMSAS sequence motif.	25.00	25.00	52.60	52.10	18.20	17.50	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.35	0.72	-4.07	19	114	2010-07-29 10:44:54	2010-07-29 11:44:54	1	1	37	0	2	107	0	104.40	60	41.53	CHANGED	usLLSGCuFGE......TKIEYERhVKALDEGDMKTVMSASDDGYAaVcEcsI....aSsaEcKEDGpHp+slYQTT-GlYNhK-KsLYGpToQplsoclcsccp+cp.psYKcEpl	.....SLLSGCuFGE......TKIEYE.hVKALDEGDMKpVMSASDDGYAYVKpcsI.....STaEpKEDGcHppsIYQTTcGlYNsK-KsLYGpToQclsoslcsccp+cc..sY+pp................	0	0	0	0
+12972	PF13131	DUF3951		Protein of unknown function (DUF3951)	Aldam G, Mistry J	gba	Pfam-B_698 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 56 and 71 amino acids in length. There is a conserved YTP sequence motif.	25.00	25.00	39.60	39.30	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.69	0.72	-4.19	4	137	2010-07-29 10:49:09	2010-07-29 11:49:09	1	1	86	0	5	52	0	50.70	61	82.10	CHANGED	MILhTIGhlLhTlFIFFIIGFlTFpMFVsKATPQIYYTPC-shTsQohpctpp	...hlLhTIG.l.LTlhIhhIIGF..ahhFlcKto.p...aYTPh-slTspohuca+.c	0	0	2	2
+12973	PF13132	DUF3950		Domain of unknown function (DUF3950)	Aldam G, Mistry J	gba	Pfam-B_688 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 30 amino acids in length. There is a conserved NFS sequence motif.	25.00	25.00	36.80	36.30	23.60	23.00	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-7.39	0.72	-4.42	8	501	2010-07-29 10:51:02	2010-07-29 11:51:02	1	1	257	0	7	125	0	30.00	81	50.68	CHANGED	LL-QIstuhtpEp....ouNFSAWVh-ACRcKLp	.MIEQINIAL-pKG....SGNFSAWVIEACRRRL..	0	2	2	7
+12974	PF13133	DUF3949		Protein of unknown function (DUF3949)	Aldam G, Mistry J	gba	Pfam-B_636 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 69 and 87 amino acids in length.	25.00	25.00	61.30	61.10	17.30	17.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.04	0.72	-3.75	5	147	2010-07-29 10:52:29	2010-07-29 11:52:29	1	1	88	0	5	77	0	60.90	70	78.40	CHANGED	MIPIQYtYIcuLK...Ec++KpGlSQcELY-NMSFEEEQLHYHsQGNlFsIPuuhVAShIY+lKp	.hlPIQY.YlphL+...EKpKKhulSQpELY-pMSatEpQlHaHhQuNsFsIPuuhVA.hIhKVK..	0	0	3	3
+12975	PF13134	DUF3948		Protein of unknown function (DUF3948)	Aldam G, Mistry J	gba	Pfam-B_550 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	25.00	25.00	51.80	51.60	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.47	0.72	-4.48	8	175	2010-07-29 10:54:03	2010-07-29 11:54:03	1	1	80	0	13	52	0	34.70	69	93.11	CHANGED	MpN.cQVLQVTKhDFLGSASGAslLTAhIVFLusVL	...Mps..EQVLQVTKsDhlGShuGAVVLTuhIlFLusVL	0	0	4	4
+12976	PF13135	DUF3947		Protein of unknown function (DUF3947)	Aldam G, Mistry J	gba	Pfam-B_493 (release 24.0)	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	25.00	25.00	26.90	26.90	21.60	19.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.97	0.72	-3.78	13	175	2010-07-29 10:55:40	2010-07-29 11:55:40	1	1	80	0	4	91	0	77.00	55	98.40	CHANGED	hssYa.sphplt.......suIThuuAQuTlpAVpQAhQ.....MQQQh..th..p.......uh..aYsshtY.......hYPs........sFoTIPaGssY.L	.........h.pYFhstttht.......suIThuGAQuTlpAV.pQAlQ.....MQQQhQ.....Q.......G....YSph.h.......hYPs........oFhoIPYGusY.L..........................	0	0	3	3
+12977	PF13136	DUF3984		Protein of unknown function (DUF3984)	Aldam G, Mistry J	gba	Pfam-B_3236 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 393 and 442 amino acids in length.	21.30	21.30	40.40	30.50	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	325	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.36	0.70	-5.21	20	72	2010-07-29 12:40:09	2010-07-29 13:40:09	1	2	68	0	59	69	0	298.50	34	77.17	CHANGED	RSRRSasSLpHlSLAPLTsRFPlDDDss..........s.tst....t.hstsspsspTSYLuShSVPsTPslL..ScSRssSpsRtp.....p+ppoopptphS-.....osLcupsstpshHHppp.............pcptpppsssst............p.ss.tppc.pDsEWLLRAGlALASSTREEKGQSWLVKR-SSTSLV..................uEss.s..ptht+ppc............tppptoRRuR......................SGhSTP...sAhSRRsSpSRsuSRtu.SRs-L..sMTuhch............sttsttths...ss..p-sp...thlPDFVDcclRsEMt.h................tp.cp..........s.............st....u-sDsE-.......-.hDEtEhQRLTRc.cGhGLGuWI.DRlVEWTLFuVE-	.............RppRS.ssLpHlSLAPLTs+hPl-D-s..............................thtsh..poSYLpuhSsPsTPs..lL..Sp..Stssupsphp.......tpss.tt.hSp.......o.h.puhsss..p.hppppt......................pt.tppphspt..........................p....shsppc.tDs-WLLRsGhsLuSpsREpKGQSWLVpRpSS.TSLl.....................spsp.s....cthtcppc......................tspptuRRup.........................Ssh....uoP...hshSRhs....S+s.sS+....hu.SRspL......MTshph.........................tt................psh...hhsPDFV-.s.+.Eh.......................................................................t-p-spp...-..DEtclpRLsRc.pshG..lGuWl.-plltWoLFuVE-...................................................................................	0	12	27	46
+12978	PF13137	DUF3983		Protein of unknown function (DUF3983)	Aldam G, Mistry J	gba	Pfam-B_2658 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 40 amino acids in length. There is a conserved AWRN sequence motif.	25.00	25.00	39.50	39.50	19.90	18.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.56	0.72	-4.27	15	83	2010-07-29 12:42:07	2010-07-29 13:42:07	1	1	55	0	3	48	0	34.70	68	79.89	CHANGED	KK+Kl+KAIsRRuKsl...EK.cRVcpAWRNIFVQAGI	.KK+KlRKAIARRsKsV...EK.aQVsKAWRNIFVQuGI.	0	0	2	2
+12979	PF13138	DUF3982		Protein of unknown function (DUF3982)	Aldam G, Mistry J	gba	Pfam-B_2022 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 47 and 73 amino acids in length. There are two conserved sequence motifs: EKL and EIP.	25.00	25.00	34.50	33.60	19.40	17.60	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.28	0.72	-4.09	20	72	2010-07-29 12:45:00	2010-07-29 13:45:00	1	1	40	0	0	43	0	54.10	58	87.08	CHANGED	M.....hGI.IshtVshTEIlAPAsNVSIVVNESESPI+hEEKLSVATAPLIEIPTPsGAHPGAVV-hDTLIT	.......hGI.IshtVshTEhhsPAspVoIV.pEot.PIph.EKLpVushPh.EIPsPsGtcPGtVV-h-pLIo	0	0	0	0
+12980	PF13139	DUF3981		Domain of unknown function (DUF3981)	Aldam G, Mistry J	gba	Pfam-B_1754 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.	25.00	25.00	186.40	185.60	20.20	20.20	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.41	0.71	-4.09	2	80	2010-07-29 12:48:28	2010-07-29 13:48:28	1	1	79	0	3	48	0	114.00	96	19.90	CHANGED	hIPWTRuuptLRsVDKcGscKVlKtKpusILhIPlLhWIGIAIYEYhWLIDDRVDSIlTHYSVslAlLIGlVLhSQsphG+LEspLKullMhILLsSYGYFGYLHDIVISQKKY	LIPWTR.SGSKLRAVDKKGDEKVVKGKKSSILVIPVLFWIGIAIYEYFWLIDDRADSILTHYSVAVAILIGLVLFSQDQIGKLEGTLKGLLMFVLLASYGYFGYLHDIVISQpKY	0	0	2	2
+12981	PF13140	DUF3980		Domain of unknown function (DUF3980)	Aldam G, Mistry J	gba	Pfam-B_1748 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length.	25.00	25.00	77.20	77.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.06	0.72	-3.71	3	79	2010-07-29 12:54:34	2010-07-29 13:54:34	1	1	79	0	2	48	0	86.60	85	67.47	CHANGED	MEQEQTSYLSIKILKIMSVIYLIVSILsAlSTGuFIpss..GFs.uISlSGoG.uAlGllhLGSIFQSVLVFCGIWVFILLVETVIKIYEK	.VEccQTSYLSIKILKIMSVIYLIGSILMAFSTGPFIHNl..GFD.EISISGSELGLISIVMLGSIFQSVLVFCGIWVFILLVETVIKIYEK	0	0	1	1
+12982	PF13141	DUF3979		Protein of unknown function (DUF3979)	Aldam G, Mistry J	gba	Pfam-B_1747 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	22.50	22.50	24.50	216.30	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.38	0.71	-4.19	3	81	2010-07-29 12:55:49	2010-07-29 13:55:49	1	1	81	0	3	37	6	113.70	90	95.87	CHANGED	hoLFQsAPhEDtKGGWKYIIQEQNGKYpIsN-IussHMSVELYFNEYDElRITLYKDGpPITTMQRIsIlKlELEEDEEGIQFVLERMPSRMIRLQLKPYLAlEMGLYWEVCED	.MTLFQAAPKE-sRGGWKYIIQEpNDKYEIVDEMLKNQMSVELYFNEYDEVKITLYK-GhPIoTMQRIAISKVELDEEEEGIQFVLERMPSRMIRLQLKPYLALEMGPYWEVCDD	0	0	1	1
+12983	PF13142	DUF3960		Domain of unknown function (DUF3960)	Aldam G, Mistry J	gba	Pfam-B_1431 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 72 and 89 amino acids in length.	21.50	21.50	22.10	22.60	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-9.98	0.72	-4.21	4	84	2010-07-29 12:59:48	2010-07-29 13:59:48	1	2	82	0	3	37	0	88.60	94	23.50	CHANGED	MhAsp..PNWsLVhDsYhEPNNFADLFSLLVPs+PKGEuKERTILsWKEKEFYKEENLhPFILYGMNKuK-LPQFHKDEIPTLVRIVRL	......MKAVQtDPNWNLVTDTYIEPNNFAELFSLLVPCHPKGEGKERTILVWKEKEFYKEENLAAFIVYGMNKAKNLPQFHKDEIPTLVRILRL.	0	0	1	1
+12984	PF13143	DUF3986		Protein of unknown function (DUF3986)	Aldam G, Mistry J	gba	Pfam-B_362 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	20.30	20.30	22.30	22.30	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.11	0.72	-3.53	12	206	2010-07-29 13:04:43	2010-07-29 14:04:43	1	1	96	0	12	100	1	86.80	50	91.36	CHANGED	hpaDsspHLHlGYY-cshDl...EulAYKphscslWslahsatthshhhpph.pth...hh-thGhpl..aolcspDLs.-tusthFEcWLhcNp	......cYDsShHhHlsYatsthD..l...EshAYKRhNEsVWDlYhsahthss..hcclEpt+.....h.-.hGhhV..aSlcspDl..s..E.upt.FEcWlh+Np.......	0	1	6	8
+12985	PF13144	SAF_2		SAF-like	Coggill P	pcc	Jackhammer:O26012	Family	The members of this family are similar to those in the SAF family, and include flagellar basal-body proteins and pilus-assembly proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-10.97	0.71	-4.82	119	1927	2012-10-01 20:51:14	2010-07-29 14:46:06	1	4	1667	0	431	1918	464	178.10	24	76.94	CHANGED	lpptlpp....hlppp...hsth........ph.........plpshplc.....s.php..hss....s....ps.hp.....h.plss...spt.tspsslpl....p....s.p..........ssp...sa...p..lalssplph....h....sphl............VAs+sLs+GphlsssDlshpphslsplt.s.shh..s...-..p..llGtps+RslpsGpslptsplt.shlVp+GppVplhAps.suhplpspGpALpsGshG-pl+V+N.pSs+llsupVpusGpVcV	........................................................................h......t.h.tp........h............p.....h.....hp................hs....s...p........ht..ss....ss.t....h...up...h..s..h.....h....p....s................s....p....haltsplp.s............p...ts.hl..................................Vuspsls.+..Gphlss....s.slp..hcp......hcl.s.p...ls..p..shl...s....hs........p...ll..st..h......ut..+.s.lssspslphstlpp..shhVptG.pp..V.lls.ps.suhslsspGpALpsushuppl+V+.....sSs....p..l....lpuhVsu.sGpl...............................................	1	114	243	333
+12986	PF13145	Rotamase_2		PPIC-type PPIASE domain	Bateman A	agb	Jackhmmer:O25628	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.39	0.71	-3.48	206	2673	2012-10-02 13:30:10	2010-07-29 16:26:11	1	27	2057	2	569	6738	2215	123.40	20	28.69	CHANGED	l....s-..p-lcphYc....p..pts..pa....t.ps.pt...p.h.hp.........hhh.hs...sp....st.s...p..tt.....tpt.....hpt..t.........sh...pp.h..ts..h.tp..t..p..shs......hps..hs...........htp.ts.....................p...hst..................................t.htptl..h...sh.....ps..G..p....h.s..s.s..l.......ps..st......u.h..hlh+lssh.p.s..sp.shs.h-..c..s..+.s	.............................................................................................................................................................o-t-lpphY-..............p....pps....pa................t..t....pt...h.t.hp...................hlt..hp............sc.........sp..A.........c....ts..............hpp.........hpt.t...............................t.......ts.F...ss...l..uc...c.....p...uss...............sss..hs................hhp.ts.............................................s..lPt.....................................p.ltp..As...h.......p.h..........cp..G..p.....l.S..s..s....l........ps..ss...........u..a.hll+lsch.p..s...tp..sts.hpcs+..........................................	0	194	373	478
+12987	PF13146	TRL		TRL-like protein family	Bateman A	agb	Jackhmmer:O87326	Domain	This family includes the Swiss:O87326 TRL protein that is found in a locus that includes several tRNAs.  The function of this protein is not known [1]. The proteins in this family usually have a lipoprotein attachment site at their N-terminus.	25.00	25.00	27.90	26.10	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.31	0.72	-4.00	22	210	2010-07-29 16:26:30	2010-07-29 17:26:30	1	1	172	0	33	102	11	77.10	51	73.76	CHANGED	sGhlaspsshPstss.......sspssKpGcACspo..lLslVuh.GDuSl-sAtcpusIsclspl.....Dapspshl..slasphCslVpGp	.........................u.huLYTcVpsPlouT.......slsuoKoGKACApo.....VLGlVsT..GDASI-oAK....KuGcIShVoSV.....DYETTGsa...sh..YGKsCVVV+Gp.	0	9	26	27
+12988	PF13147	Amidohydro_4		Amidohydrolase	Bateman A	agb	Jackhmmer:O25045	Domain	This family of enzymes are a part of a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.94	0.70	-4.37	111	10639	2012-10-03 00:45:34	2010-07-29 18:01:37	1	79	4086	62	2860	18795	7896	309.00	16	70.36	CHANGED	Dsp...G.thlh..PGhlDhHs+.....................hstthsst.ht.hh.........tuhhshh............tsshpssthttthtp........................................hhh.sththtsttthhtthpphhthhtttshsh.th...............................thttsthtthhp...tstpts.hhhhhsttstt.........tt.httththhthh........................hthstshplhpthssthshththhttttsthh.t.............hthstttslssssht.......hhp.h.th................shthhhhssh..................tptshtsltphhpsG...hhhhluoDth.........................sssshhtthhhhhht...hshs........pslphsotssuphhsh........tphGtl..t.GtpAchl	........................................................................................................................................................................................................................................................................................................DspG.thlh....PGhlD.hHsH...............................................................h..t.t.s.s.h...h..h.p....s..h.................................h........t..h.suGhoshhp...............................hssspsthh.ttth.hp.h.................................................................................................................................................hhh.h.h..t..h..h..h..t...t.........h..h...t......th..p...p...h.t....t....h....h..t.......h..t...h...h...s.h....t..h..............................................................................hh.sst..h..h.t.hht..............tt..........t.ths................................hhhh..t.tp..t.......................................t.h.h..ttt..t.h.hh.................................................................sts..hp..h..h..h..h....h..t..t....t.......h....s....h...th.ph....htt..ph.st.......t.ht.................................hths..cttulssst.t.....................................................hhtpth.th...........................................sshhhh..sPsht................................................pppshtsl.h.......p..h.lp.sG.................shs.s.lu..oDa.ssts....................................................................................shts.hl.hh..h.t.hhht....................htl.oh......t...............................phlph..h.o.ts.sA.c.hhsh..........................tptGpl.......tsGtpADls.........................................................................................................................................................................................................................................	0	927	1826	2398
+12989	PF13148	DUF3987		Protein of unknown function (DUF3987)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	27.00	27.00	27.00	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.88	0.70	-5.90	117	899	2010-07-29 17:03:48	2010-07-29 18:03:48	1	19	543	0	189	834	169	314.80	20	61.84	CHANGED	ppspsshshhshusLsslusshtst.sclph....sshht..sssLahhslupuGpt.Kosstphhhtslpphcpphtpphppphppactpt....th..hphctpshcpphtt...t......................ttppPphP......t.pllss-sTspulhptLtpsss.shhlhssEusshhsuhs.h......phhpphshhpcsacGss.lshsRpspsp..ht.lpp..spLolhlssQPshl.phlhthps..hpspGhhuRhL...hshPsstttp...c............shsp....tthpsatpclpplhpt...............tttp.hhlphoscAppha.phasplcpch.t.suph.....hpshsuKhsttssRlAullphhc..............................................ttstpIss-shptAlp.lscahhpcutclhs.hhsssp	..................................................................t....h..shhhhuhLsshuh..shts..........hplth.....sshht.sssLahhhlu.supt.Kos.h.t.h.h.h.t...........hh.hcpthhpphtptht.t.aptt.......hp.p.tth.pt........................................tpts...P.....hhhhlhs.s.sT.pulhp........h...tps.t...shhlhp.sEhss.lhsshs...........pt...sh....hpphas.......Gs.....s...lshsR...ps...pst.....hh..lp.p....splolhhhhQPshh.phhhptps.........sp.....GhhuRhL...hshP.s..s...tphh..p...................................p.....thhptht...p.phpclhph.h..........................................ttp.hs..lpho.sp.Appha.ph..hp.p..ltpch.t.....s.......hps.hhs.+h.st.hhRlAhlhthhp....................................................tph...Is.pshptAht.ls.p.ahh.p.chhhl.s......t............................................................................................	0	73	131	165
+12990	PF13149	DUF3988		Protein of unknown function (DUF3988)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	29.90	29.90	29.90	29.90	29.20	29.80	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.44	0.70	-4.89	252	1094	2010-07-29 20:05:34	2010-07-29 21:05:34	1	66	98	7	150	1009	2	288.40	14	64.34	CHANGED	hhlsuCspsc......................t.t.stststs..........lplsss..................ststTRusss..............tts....-plG........lash..............................t.ssshsstthhsshhhhtss..............stshssss.thaa........s.spphsh.hA....Ya......P.........hpssssss........ht...ssssp......................t......................Dh....lhApsps.........sssssshs........................tFpHthopl.plplp.t..ssshsst.....hh....plpshtsp.................ushs.....h.....sGshsssss............................ssshshts...sssshsh...........hhll..P.......................tsst.........hplphshssp......stphhhsstttt..........................sGppasas.........lslsps...........hhhsssslssWss	..................................................................................................................................hhsuCspcp........................t.....tstpts...............l.phsss.....................ssstTRusss............thpss..........cplG...............lash.................................ts.sst.hhssh.hh.h.tss..........................................shshssss...hha.........s.ssph.sh..hA.............Ya..........P.........................asssssss............shs...hs..........hsspp...................................t......................Dh........hhupsps.....................tsssssls.....................................h.....pF..pHthopl.plplp.s...ssshsss.......................h....hplps..h..tsp...................................ushs...............hs.........sGshsssss..................................................s.sshshtt......sssstsht..................hllh.....P......................tsss...........................hpl.phsh..sst......................shthhhsttth...........................................sGppaths.lplstt......................t.ph..W......................................................................................................................................................	0	23	126	150
+12991	PF13150	DUF3989		Protein of unknown function (DUF3989)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	27.00	27.00	27.00	27.30	26.40	26.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.60	0.72	-4.53	17	195	2010-07-29 20:28:02	2010-07-29 21:28:02	1	1	80	0	16	135	3	83.90	32	85.32	CHANGED	+phlcthpcth-scLRthhstLsPctRlhllLshhshFusLulYhhssuIacl....G+p-tpphpIcHIcpl-L....pp-ohNhhp.hp	............h.hlpchpchhss+L+thhstLsPcpRhtllLsMhshFusLulYhhspulYcI....G+..p-G.pc..hphcHltplcL.........s-ohp.hp....................................	0	4	14	16
+12992	PF13151	DUF3990		Protein of unknown function (DUF3990)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1].	27.00	27.00	27.10	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.86	0.71	-4.84	47	384	2010-07-29 21:37:02	2010-07-29 22:37:02	1	9	247	0	57	326	11	140.90	29	74.19	CHANGED	hhLYHGSsphlc.pPclttu+.ppDFGpGFYsTp.h-QApcWApph...........tpsshlNhYpl-hsthp...LclhcFp.thspcWLsFlhpsRpstt....................csYDllhGshADD.phashlptahsstIoh-thhctL+htp..spQhshpop+Als.pL+ah	...........................hlYHG....S......s.....h.......l.....c......p.......P..ph.ths.......+...p..h..DF...G....p....GFYhTs.hcQApcWAtph...........................ttpshls..hYphs......phh.......hphhhF........p.....ths.cWlpFlhpsRpt..pt....................ppYDllhGs..hAsD...phh...phlp.ahp...s.......h...........l.......sh...c....p...hhpthp..htp......spQhshtoppshp.hLph.h................................................	0	28	42	49
+12993	PF13152	DUF3967		Protein of unknown function (DUF3967)	Aldam G, Mistry J	gba	Pfam-B_1529 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 173 and 249 amino acids in length.	21.60	21.60	21.60	22.20	21.30	21.40	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.43	0.72	-4.31	15	228	2010-07-30 08:43:20	2010-07-30 09:43:20	1	2	107	0	8	152	0	35.30	50	17.38	CHANGED	RtppRDppLMpsIRElQEoK+LIAAScpK..hpFW	...+.ppRDppLMpsIREIQETKR....h.......lA....Ao..KE...p...p..hhp.a................	0	1	3	3
+12994	PF13153	DUF3985		Protein of unknown function (DUF3985)	Aldam G, Mistry J	gba	Pfam-B_3329 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	25.00	25.00	82.80	82.60	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.38	0.72	-4.15	8	55	2010-07-30 08:48:10	2010-07-30 09:48:10	1	1	55	0	2	11	0	44.00	94	95.65	CHANGED	MEILoIILIVLLIYVVFKVAYVALKILAILLIIFLIVEFGSKLL	MEILTIILIVLLIYVVFKVAYVALKILAILLlIFLIVEhGSKLL	0	0	1	1
+12995	PF13154	DUF3991		Protein of unknown function (DUF3991)	Coggill P	pcc	Jackhammer:O25192	Family	This family of proteins is often associated with family Toprim, Pfam:PF01751.	22.20	22.20	22.20	22.40	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.75	0.72	-3.79	113	763	2010-07-30 16:16:39	2010-07-30 17:16:39	1	15	512	0	102	654	29	82.50	24	16.66	CHANGED	sYLpppRtlstpllpthhp.....pshlhp.........sph............t......Nhl........FsttD.............p.pGpspGhphRGs...................ttsa.+uhspG.......sshhashsh.........sps	.............tYLpppRslsppllpthhp.....pshlhp.........sph................p..................sll........Fhth-.....................ppsphtuuphpGh....................ptsa.KthspG.....sshthuhsh.......s..........................	0	36	72	92
+12996	PF13155	Toprim_2		Toprim-like	Coggill P	pcc	Jackhammer:O25192	Family	This is a family or Toprim-like proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.64	0.72	-3.67	328	1811	2012-10-01 21:47:57	2010-07-30 17:17:53	1	42	948	0	254	5018	2583	95.50	22	20.72	CHANGED	hlhEuhhDslShhp....hthps...................slushGsshp.........pthphL..pph...tp............lllshDsD...........pAGppAsp+hh..phhtp.....................hphphhphstt.c.....D...hs.........-hl	.......................................hlhEuhhDhlSahp......lthpp..t..........................lsl.susu..s..h....t..............................phhphL.....pth........pp......................................lhhs.hDsD.............cAGccsspclt.....pthttt...............................................psth.h.h.tt..K......DhN-hL..............................................	0	97	201	234
+12997	PF13156	Mrr_cat_2		Restriction endonuclease	Coggill P	pcc	manual	Family	Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2]	22.00	22.00	22.10	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.61	0.71	-4.24	8	260	2012-10-11 20:44:47	2010-08-02 13:31:32	1	15	227	0	57	253	94	120.90	35	9.82	CHANGED	csDPshpspYscVpTas-WAc..pGhsppDTGIDLVA+hRcsDuasAIQCKFYsssHpIpKsDIDSFhsASGK........c.FopRlIlsTTc.cWScNAEshLcsQplPlsRIsLscLEpSpIDWstats+ucllLp	.............................-Phhtppa.c.pVahWtD......Ws..........p.....t..s.....pp..DsGIDL.VAp..pp..s..........s...s.p.......a..hAIQCKFY....pss..t..pltK.s-.IDSF..hs....s....SG.+...............sh..Fsp.R.lIlo....T...Ts.cWu....p...NA-cs.l....ps....Q.t...hslp+Isht-ltp.....S.IDWshh..t......t.............................................................	0	17	32	42
+12998	PF13157	DUF3992		Protein of unknown function (DUF3992)	Aldam G, Mistry J	gba	Pfam-B_480 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 98 and 122 amino acids in length. There is a single completely conserved residue T that may be functionally important.	22.00	22.00	22.00	22.90	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.14	0.72	-3.79	10	220	2010-08-02 13:24:37	2010-08-02 14:24:37	1	1	84	0	11	114	0	90.20	46	77.59	CHANGED	VCssWshs..suAsshllYssNlsQsIsGTGaVchDsGsu.....sITVshl...ssGTsVsThTVsPGoStSFThRcFsoIpIls...ssuGoppGcaClTh	.............VCosWSh...ssAhspllYTNNIsQpVhGTGaVKYDVGsu.....PITV-hL...suGTVlDThTVpPGoShoFThRcFsolpIss......Tssss.QGEFCITs.........	0	0	5	5
+12999	PF13158	DUF3993		Protein of unknown function (DUF3993)	Aldam G, Mistry J	gba	Pfam-B_782 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 160 amino acids in length.	22.40	22.40	23.60	63.80	21.20	20.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.37	0.71	-4.31	5	94	2010-08-02 13:25:49	2010-08-02 14:25:49	1	1	94	0	5	39	0	119.70	79	72.48	CHANGED	hIhLlthlsVAFLVsaulTpl.uK-csKlDRcEVFpTlQouaEsQFSLoEKcRoMs-MhulL-PYFT-uFtslFl-ENups-cpG..haGoDhGEYhIPs....FSFou-TKluhD-E+..lYVYEass	..................GIWLVLFVCVAFLVGYSVTTVLGKEEVKlDRKEVFTTIQKGYETQFSIRGKHLPMNKMIETLSPYFT-NFLQVFTDENSRSDKQS........GEYLLPAKEAPFSFNSETKMSYDEEHK.LYVYERs...	0	0	2	3
+13000	PF13159	DUF3994		Domain of unknown function (DUF3994)	Aldam G, Mistry J	gba	Pfam-B_903 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 97 and 111 amino acids in length.	25.00	25.00	25.40	27.40	21.60	24.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.65	0.72	-3.79	21	98	2010-08-02 13:26:55	2010-08-02 14:26:55	1	1	44	0	2	81	0	109.20	40	32.91	CHANGED	psKphs-cupchlccGschWppsacslcsch.tt.p...............sthptsohossc.p..p......................sspsslspDGpELlGsWGh.pss.tFphulsh+p..DsTFpsYss.uphs	.......TDKEll-KupphlcEucphWt.sFccLcu-h.t..tt...............phssuosSspchpphptKsGl.ps..............NsppNl.KDGTELlGsWGhptus.GaphoLlLKu..DKTFEoYus.GpYP...	0	0	1	1
+13001	PF13160	DUF3995		Protein of unknown function (DUF3995)	Aldam G, Mistry J	gba	Pfam-B_958 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 138 and 149 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	22.70	22.70	24.00	23.10	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.83	0.71	-4.08	35	198	2010-08-02 13:28:22	2010-08-02 14:28:22	1	1	181	0	58	169	10	119.90	35	82.04	CHANGED	hLssluhlH....lYWAhGGpWshps.shsspss.......tsshtPuhsushhVAssLhsu..Asllhhpsh.h.ht.hh.ttlh..phushsluslhhlRu.....lushtaluhh+chts..shFuchDshlYsPLCLhLuluhh	............................hLhhluhlH....lYWAhGGpWussu.slPscss..............chshpP.sshh...TL.hlAlhLshA..Ahllltpss.h..hththsshll.phuuhls...hllFhlRs..............lG-FpYhGh.FK....+h+s..opFA....RhDThlY.PLChhLuluh.........................	0	16	35	46
+13002	PF13161	DUF3996		Protein of unknown function (DUF3996)	Aldam G, Mistry J	gba	Pfam-B_998 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 203 amino acids in length.	21.90	21.90	21.90	29.80	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.18	0.71	-4.58	16	146	2010-08-02 13:29:55	2010-08-02 14:29:55	1	1	31	0	17	100	1	156.00	34	82.20	CHANGED	ths+pptsppphGhGhulssPIsNhhlphshhsl-IGaGsaNGlpss.........sFhshlhhul......DhlFhpphhcphs..lssulGhGh....GphhhSshpsst................psssphulGhRlPLhlpaslh.Ksl-IhhKssPuIt.shahsss........h.Gh+aphFuuhhl+h	...h.tKcppsppthGhGhulG.PlANhhlshsasshDlGaGuasGlpss.........sFhshlhhul......DhIFpp.lhcshs..lshulGhGh....GslhhSs.ppp.................o.ttclulshRlPLslpYshh.+slpIhhKhsPolt.shhhsss........h.Gh+aNFhushhl+h..............	0	5	7	7
+13003	PF13162	DUF3997		Protein of unknown function (DUF3997)	Aldam G, Mistry J	gba	Pfam-B_1597 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.	25.00	25.00	27.20	25.40	24.70	24.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.45	0.71	-4.26	10	103	2010-08-02 13:32:12	2010-08-02 14:32:12	1	1	101	0	15	57	0	109.60	67	75.10	CHANGED	pls-tYcLlNsussshtlhs.psslhpopa.h.l...sApVs..-IuaD-paIIAKpp..ph+sDshNscsslhscpsE...YWIIDlK......pschaGPasccpFpcKpcphpIscplphlpsahp	...............................................lNDEYELIRTSGNAFELFPoQDAVYATQY...I...PAKIT..DIAWDDKYIIAKQT..EEKSDPNNPDAAIANKKSE..HYWIIDVK........HNKRFGPYNEKQFpEQKDAFKIKVPFQslDuYI.K...	0	4	12	13
+13004	PF13163	DUF3999		Protein of unknown function (DUF3999)	Aldam G, Mistry J	gba	Pfam-B_2128 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 440 and 470 amino acids in length. There is a single completely conserved residue D that may be functionally important.	29.00	29.00	29.30	29.00	28.40	28.60	hmmbuild  -o /dev/null HMM SEED	429	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.35	0.70	-5.53	34	171	2010-08-02 13:36:19	2010-08-02 14:36:19	1	2	165	0	56	185	19	389.10	29	87.18	CHANGED	stDaupthsLphsuu.usaYpLsLPtsVYttutpsD.LsDlRVFNusGcslPaALhtspst..s.ss..phpslphFsL.....sssuss.spssspltlptsssGsl....hthsssstssptpt..t.aLlDhoth......cs.slptLhLch.ssstps..clsVcASDDLpcWpsl.ucutlhcLspssppltpccIt.....Lss..hpuRYLRLhW..s..susthpssplpttsssshss.........shpaptsltsppsss.....spahaplstshPlsclclsLsQs..Nslssspl.u.......................Rssspt.......sWpslusuhL.aRLttsu..tc.tsssltls..spsscthRlpssp...uGhGsssPsltsuhpstpLsFlApGssPapLAhGssssts........sslshssLlsshpstp........ls.Aphst.....ssssussshhs..sssps...h++hsLWusLllG..VssLuhhAapL	.................................saspphsLphsut.usaYplpLs.sV.htutpss.LtDlRVhsutGpslPaul.s.pst..ttts...p.htlphFsL......sstts.ttsss.hhlph.sssGsl.......tststsuttth......saLlDhSth........ct..slptLhlca......ssshps.tphsl-uSDDLpcWpsl.ucuplhcLshsspplppccls..........................Lsu....tpARYLRLhh.ts.tsuP.tLtsscltsts..sss..ss.............shpWptshtsptsss............schhaph.ss.s.hPl..sclclslsQs...Nsls.spl.tu..............................Rssspt.......sWp.slusshL..YRLtts.s....tphpsstltls....uphs+thRLhlcp.s..sGLus.t..sP.pl...s...l.uh...pstp..LsFl.....ApG.ssPasLuhGssssps........s.slslssLlsshs.pp........ls.Aplus......htsussshh..s..sssps....h++hhLWusLllu...VhlLuhhAhpL.......................	0	10	27	41
+13005	PF13164	DUF4002		Protein of unknown function (DUF4002)	Aldam G, Mistry J	gba	Pfam-B_3350 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 112 and 125 amino acids in length. There are two completely conserved C residues that may be functionally important.	21.00	21.00	24.50	23.90	18.20	17.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.51	0.72	-4.00	26	48	2010-08-02 13:38:04	2010-08-02 14:38:04	1	2	18	0	22	50	0	74.50	36	63.43	CHANGED	CC......p.tppltaphtpst.......Ctshsupts.....tsC.phsICsDGpsl.hGs.aCGpGsCNlFGCsCcGGCl...pGshhpsFhcpssth	............................CCh.ttpltaphttus.......Cthssupts....shsC.chsICsDGpsl.hGo.YCGpGuCNlFGCpCcGG..Cl...pGsh.psFhchst.........................	0	5	5	15
+13006	PF13165	DUF4001		Protein of unknown function (DUF4001)	Aldam G, Mistry J	gba	Pfam-B_3337 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are at least two pairs of cysteine residues in this short family of proteins.	21.70	21.70	23.10	23.00	20.80	17.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.58	0.72	-4.29	32	277	2010-08-02 14:58:05	2010-08-02 15:58:05	1	2	276	0	55	184	1	43.90	66	92.19	CHANGED	KHIKTlsppsLpcohppGG.CGECQTSCQSACKTSCTVuNQsCEp	................KHIKTlNp.psLp..po..lp+GG.CGECQTSCQSACKTSCTVuNQsCEp...	0	36	51	53
+13007	PF13166	AAA_13		AAA domain	Bateman A	agb	Jackhmmer:O25761	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease [1].	45.20	45.20	45.30	45.40	45.10	45.10	hmmbuild  -o /dev/null HMM SEED	712	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.59	0.70	-13.53	0.70	-6.07	43	601	2012-10-05 12:31:09	2010-08-02 18:32:18	1	5	517	0	126	556	33	537.10	15	85.43	CHANGED	shusa.s..tp........ssp..lss.......hp+lNlIYGtNGoGKTTlSplhtshp.....s........cap..............ps.ph............phps.............s....p.............s..plh..VaNp-Flcc..Nh....s.....p...sp..lpul.asLGccsh-tpppIpphcpplpphppp..hpphp....pplpp..tpp.........phpphpsphp..cpshcph.pp...hppthp.pshpu..hpt.cpph........tpphlp..c.hps....hsts......shhs.cclpp.p....hptl.hssshpp.lshl.s....hs.h.s.hpt.l..-p....ssllpppllup...s.slscLlppls.s-WVc.............pGhc.ahp.......p..s...ppCsFCpp..lspphtppLppaFc-.sa...ppphpplpphhpph...psp...hpt..hhpp.lpphh.s.h..............t.hthp......hpplpp....ph.pt........lppt....l....pt...p....ppLppKhpcPsp.slp.l.csh.sshl......s............................plpshlsphNphIpcpNc....hspNhppcppphp.pplhtah.h.........t.chp..pslp..thp....cphp...shppslsshppplsptppclpshppc....lpcLcpplsshp.slcpINchLpsa...GhsshpLp.h....ps.c....c.st.....YcIhR.....p..s....s.p.ss...psLSEGE+ThIsFLYFhptlc...sss..sh..t.cspllVIDDPlSSLDsshlahlsuLI+shh......tp.sp.............h+QlFlLTHNlhFa+clp..h......hhp........p..........p..pts..p..p........spaa.h.......................lc..+...sss....tSpl...p.............sh.p.p.....pshpopYphL.appl.......pct..............t.........pps.....ssh.slsNshR+lLEsY..Fph...sph.....p...........c.plh.phhps..........pcp.th...tpu.lhcal.NctSHst.s.s-l.hshst.shp.chhplhcpIFp	.........................................................................................................................................................................h..............................h..shhaG.NhtGKoshsphh..................................................................................................................................................th...ha.tphht....h...............t...t................h........h.t...............t.h..t..t...h.......................................................................t.h...................................................................t..........................................t.......t.................h..................................................h.........................t...........................................t......................t.a..ht........................................s.ht.h...........t.t......t.C.hCtp.........................h..ht....h...tt...h...hp...p......t.t...........hp..t.....h....t...................h....................................................t.h...........h.t...........h..t.....h......t...........t..h....t...c............t..t..t.........................t....................................................................................................th....t.h.t.thtt..h.t.pp.......t.t.....h..t....t.....t...h....t........h..............................t............................ht.......t........h....t..t..t....t.h....t.t....p......t.htt.hp..t.t.....h..tth.p.t...ph.............p........h.....t.....t.....hst.lpth......t..th..p..lt..h.......ptp......ptt................ht.l...t............t..s.............t.p.........pplScGEcshluhhaFhtphp..............ptp.sh...........ptthlllDDPlSSLDppphhh...lh.sh...ltphh.................sp...............hp....p....lhlhTHsh..Fh.p.lp..p..hp..........................t..tp...............phh.h..........................................................lp.p......ptp.......p.h..................htt........p.h.p...a.t.h..h...ht.l.hph..............t.........t.t.........h..h.N.hRplhE...h..hth....t.........t.........................h.....t.h.t..................................h..phh.p..S..H.....................................................................................................................................................................................................	0	35	78	107
+13008	PF13167	GTP-bdg_N		GTP-binding GTPase N-terminal	Coggill P	pcc	manual	Family	This is the N-terminal region of GTP-binding HflX-like proteins. The full-length members bind and interact with the 50S ribosome and are GTPases, hydrolysing GTP/GDP/ATP/ADP. This N-terminal region is necessary for stability of the whole protein.	21.90	21.90	21.90	22.30	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.10	0.72	-3.86	6	4196	2010-08-04 10:27:35	2010-08-04 11:27:35	1	5	3967	0	960	2981	1188	93.80	42	21.38	CHANGED	DcpFNF-STMEELpuLSpTCQL-VhuQITQNR-pVDcKYYVGKGKl-EIKuFlEh+DI..DVVVsNDELTTAQSKoLN-sLsVKIIDRTQLILEIFA	..............................tpt.......ttsh.pELtsLuco.A.G..s.cl.l.t.s.l.sppRppsc...sphalGpGKl.cEltp.h...........l.......c........t........p...............s..............s....................s.lVlhs.c.c.LoPu.QpRN....LE......ch.h..............p.........s+V..IDRTtLILDIFA.............	0	319	633	820
+13009	PF13168	Poxvirus_B22R_C		Poxvirus B22R protein C-terminal	Mifsud W	pcc	Pfam-B_3510 (release 7.3)	Family	This is the highly conserved C-terminal region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.	25.00	25.00	211.20	210.90	20.70	20.40	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.08	0.71	-5.04	19	94	2010-08-04 13:07:16	2010-08-04 14:07:16	1	2	34	0	0	88	0	196.20	58	10.66	CHANGED	cspslhpsVSs.uLoplGuslusuG........hsuuPplAhAGhulpuIuGLIDhupsIYallSGpp...P.DPllcpFssYupalu.oscuGsRhChMPsS-lhlhlAYRp.....cs...p.uhEKhthaahDslsShlhYLpTStIshshplpVsCP.IGtLR.h-sDIsuYshLhhssc-sV+aYhhstlhshLSpaPsVphTCGp-.sLh	..K-EKIFEAVTh.oLSTIGSTLooAG........hhusP.LMIAGlGIohIoGlIDsuKDIYYLhSGpE..+PVDPVIKhFNTYAuLVSDosKhGVRKCLhPGpDTlIYlAY+N.....Do.SFKpssEthuLYFlDVIsScIhYLNTSNllL-YpLKVACP.IGsLRSlDlDITAYTlL.Y-TsDslK+Y+FlRhusLLSKHPVlRLTCGhssTL...	0	0	0	0
+13010	PF13169	Poxvirus_B22R_N		Poxvirus B22R protein N-terminal	Mifsud W	pcc	Pfam-B_3510 (release 7.3)	Family	This is the highly conserved N-terminal region of poxvirus proteins from eg, Fowlpox virus, Myxoma virus, Lumpy skin disease, Variola virus and other members of the Poxviridae family of double-stranded, no-RNA stage poxviruses.	24.70	24.70	25.10	57.90	23.60	24.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.13	0.72	-3.80	18	90	2010-08-04 13:12:09	2010-08-04 14:12:09	1	3	32	0	0	83	0	90.90	44	5.09	CHANGED	pcpChRKhulYHshspshpt.+-phDhpup..ush+YLslscptEppphhpsFNWopIppsl+cpFlppCsssss.......YhYNYolshslolsspssh	...ETChRKoALYHD.phscs..c-NpDssAS..lsYKYLpVVpcRERoRLluoFNWTsIuEuV+N-FI+hC-lsus.......YLYNYTIslShhIcupc..ch..	0	0	0	0
+13011	PF13170	DUF4003		Protein of unknown function (DUF4003)	Bateman A	agb	Jackhmmer:Q188C9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 327 and 345 amino acids in length.	27.00	27.00	30.40	29.50	22.80	19.10	hmmbuild  --amino -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.73	0.70	-5.16	20	197	2010-08-04 15:11:32	2010-08-04 16:11:32	1	1	189	0	22	159	1	290.40	39	89.43	CHANGED	csYcplcps.thphssshlphhhAhhashpscphs..hschcclpphIKppouhFSshRuphphsluuhLslcts..psccthpphlplYspLppttFpcsp.ahhLuAhhlhpp..pppshcpplp+spplYcthKccH.FLTus-DhshssL.LAt..sspsl-plh-phEphYphLpc.hsht+uNsLQhLSplLsLtpspsppp.st+shplhptLcccclKlpp.a.hshlGlLullpssc.c.lcslpplh-pLpccctht...hp+chphhlAlsLhhschhsppp........hhcpsLttslphlltspps	.............sYtpLKsp.caphpDsRhthhIAthaAuss+lhs..ht+FhEIspaIKpQlGhFShL.......+.uhpRaslAuhLslc.s..sh+cuhcphlclYcpLlpuGFpRoh.aTYLAAhlLLpp......pp-phsppIp+uhplYctMKK-HhFLTuopDhshAVL.LAs..psEsl-pLh-csEhhYpcLAp.tGF+KGNsLQFLSpILoLtps.c-phhlupsssIhp.LKpc.clKlKphH.YPuIGlLALlpDu-.K.lculpslI-cLptc+hFR....app-tslhlAIpLassppu-c.p........tpspGLts.lclLItAQQA......................	0	9	17	19
+13012	PF13171	DUF4004		Protein of unknown function (DUF4004)	Bateman A	agb	Jackhmmer:Q183T3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 210 amino acids in length.	27.00	27.00	27.00	49.70	21.90	20.70	hmmbuild  --amino -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.30	0.71	-4.15	9	172	2010-08-04 15:48:56	2010-08-04 16:48:56	1	1	169	0	26	122	0	196.20	57	94.62	CHANGED	EpLISKKELL-hssISYGQLYRWKRKNLIPEEWFIRKSTFTGQETFFPR-KILpRIspIpphK--lSLDELAchFSsp.hp-lplsppcllpcsllScsslchatp.hs.ptpsas.pcllslal...LEcLLpSG.lSl-EuptlstsLcpp.tp.ppKpspLhlhRKLGlshahllussscIhh-sssKVlp+lslsch....hEc	..p.-LISKKDLLELTGISYGQLYRWKRKNLIPE-WFlRKSTFTGQETFFPKEKILERI-KIQoMKEDLSLDELAsMFSPs.lp-lhLT+--lL+KGIsScsVLphFhEpps....css...pFpFs-lLhlYh...LEcL..LQSG-ISLEE.GKhlhpVLc-N.Ypuh.ccKss-Lll..lRKLGloTChLl.uss--llFEcGsKlVlR.slh+h.oE.t............................................................	0	8	16	20
+13013	PF13172	PepSY_TM_1		PepSY-associated TM helix	Coggill P	pcc	Jackhammer:O25020	Family	This family represents a conserved TM helix found in bacteria and archaea.	22.90	3.00	22.90	4.30	22.80	-999999.99	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.31	0.72	-4.10	183	2589	2012-10-01 23:59:14	2010-08-05 10:40:52	1	41	1548	0	728	5088	380	32.10	26	8.70	CHANGED	htphhtphHhahuhhshshlllhulTGhhlsapp	.............hhhphH.hahulhssshlllhulTGlhhha..............	0	180	437	605
+13014	PF13173	AAA_14		AAA domain	Bateman A	agb	Jackhmmer:O25880	Family	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.88	0.71	-4.24	476	3483	2012-10-05 12:31:09	2010-08-05 13:21:57	1	24	1307	0	833	5752	2489	125.60	23	29.71	CHANGED	sptslllpGsRpsGKool...l.hph.hpphh........pphlal.s.h-c.....ph................ht....ht.....t...h.................phhhp.h....h...............tt.h..lhlDElQps......................s.s.h.phl+tlh-.......pt...t..h....clhlTGSsshhl...p.phs.........splsGRhh............hclhPlSFpEah	...........................................t...hlllpGsRpsGKosl...l....tph...hpphh..................................tph..h..h..l..s...h-s......ph......................................................tp...ht.....t..................h....phhhp.t.......t......................................ttth....lhl...DE....l....Q..ph..................................s..p..h...p.h..l.+thh-..........pt.......p.....h..........ch.h.loG..S...s..s..h...h..h......p.....ph.s.............p...h..s..G.R.hh..........................h.p.lhPhoatEh..............................................................................................................	0	327	580	714
+13015	PF13174	TPR_6		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:O25749	Repeat	\N	25.70	10.00	25.70	10.00	25.60	9.90	hmmbuild  -o /dev/null HMM SEED	33	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.27	0.73	-7.87	0.73	-3.13	402	6355	2012-10-11 20:01:03	2010-08-05 13:32:42	1	1348	2675	10	2337	34545	12501	32.30	19	8.58	CHANGED	pAh.hphu.hshh.p.t........t.pts..pAtp..hhppllpp.aPso	........................................................sh.hphu.hhhh.p.t......................................s.php.....pAhp....happllpp.aPp...................................	0	982	1643	2054
+13016	PF13175	AAA_15		AAA ATPase domain	Bateman A	agb	Jackhmmer:O24997	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.61	0.70	-12.52	0.70	-5.43	19	1024	2012-10-05 12:31:09	2010-08-05 14:14:22	1	20	787	0	211	6175	1983	226.90	14	45.90	CHANGED	l+plpIpNa+shpsh.............................clshsc..........sls........lllGpNssGKoslLcul.........t.h.s.p.....tp...............................................t.tph....pp....hp...................h.tt.ptlplpthlppssschhus.....h...p..h....ppspsp..hhhh.p.lc.thchhh.sphpchchhpphst..................................................ph..h....t...p.......phph.ph.hhtth.p.....h..pt.h.tt.phhpchhssts..phpphhp.shhcthct................ttcthhpshspplpphhpcths................tshthp.spphts...........................st.hp.phplsps.lphhhp.........psp...p......lslpppupGhp.hhhhslhhsphptps.sp..........IllIDEPEsaLHsshQpphlchLpphsp..........sh..QlI.................lTTHSPall	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h.....p...t......t...u.......G....hp...............h.h...h.............h......h........h..................h..t......t..t.....h..t...t.......................................lhhl-EPEsphHsphQh.....h.h.p.h.l....p.h.ht..................................th.....Qhl.................lo.THSshl.............................................................................................................................................................................................................................................................................................................................................................................................	0	67	124	176
+13017	PF13176	TPR_7		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:O25374	Repeat	\N	25.00	14.00	25.00	14.00	24.90	13.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.64	0.74	-8.06	0.74	-3.73	162	2738	2012-10-11 20:01:03	2010-08-05 14:29:41	1	891	1597	5	1042	30248	7638	35.70	24	5.94	CHANGED	sl.ttLuph.app...tGchccAlphacp.......l.tht........ps.tstp	...............h.hsLGpl.app.......pG.ch-cAlchapp...................h.t.t..................ph...............................................	0	404	612	833
+13018	PF13177	DNA_pol3_delta2		DNA polymerase III, delta subunit	Bateman A	agb	Jackhmmer:O25829	Domain	DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalysed reaction [1]. The delta subunit is also known as HolA.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.08	0.71	-4.58	82	9575	2012-10-05 12:31:09	2010-08-05 15:02:19	1	36	4883	47	2332	8351	6088	159.20	34	34.48	CHANGED	tpsphhphLpptlpps...+luHA..YL.FpG.pGsGphphAhhhupt.lhCpptt.t...............sCtpCpsCp.pltp.........................tsaPDlhhl...........ps.cst.....................................................................................................................................sI+l..-pIR.pLppphshpshc.up.hKlaIIcsA-phstsAuNuLLKhlEEPs.spslhlLlopshspl....LPTIhSRCpllphpshs	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................pt.hhptLtp.u.l..p.p.s......+l.sH.AaLFs.Gs.cGsGKsshAphhA+.sl.Cpps.ss.......................................psC.spCp..s.Cp.....tlpp..............................Gp.asD...l...h.tl...........................cs..sup................................................................................................................................................................................................................................................................................................................................................h..s...l........-......c...l.........R.......c.......l..h....-..p....s.....p..h..s.....P....s......p.....u....p.....aKValI--sc...h...L.....o...p.sAh......NALLK.T.LEE.P.P.sp.s.....h.FlLs..T..s..c..s.p..+l...........sTIhSRCppaphp...s............................	0	792	1517	1986
+13019	PF13178	DUF4005		Protein of unknown function (DUF4005)	Coggill P	pcc	Pfam-B_2171 (release 24.0)	Family	This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.33	0.72	-11.05	0.72	-3.79	69	399	2010-08-05 15:10:13	2010-08-05 16:10:13	1	6	28	0	239	398	0	120.00	20	26.44	CHANGED	soPp...............s...t.ttt.t.sss.p..tt.........................hPsYMAsTpSu+AK..lRSQSuP+.QRsps............tppssp............+RtShss.ss.s...............tttts.+Sss	..................................................................................ts....................t..t.......p.....p.ttppp.h..s...........................................sshPsYMAsTpSA+AK..s.R.....u..p..S.u...P+..pRsp.s..........................pppssp........................+RhShs..sssstt...........................tthtt.............................................................	0	31	151	199
+13020	PF13179	DUF4006		Family of unknown function (DUF4006)	Coggill P	pcc	Jackhammer:O24959	Family	This is a family of short, approx 65 residue-long, bacterial proteins of unknown function.	20.90	20.90	21.00	21.50	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.12	0.72	-4.42	21	189	2010-08-05 15:41:21	2010-08-05 16:41:21	1	1	189	0	21	73	0	65.00	57	90.90	CHANGED	M.ps.pRslFuLNGloGhLlAsVLLLuILssLThhuItsQpssAspsYp....lpcssulKMh..uspNsc+hh	...MENsNRsVFuLsGVTGMLIATVLLLuILVsLTlWGlKsQQEVhQpPYo....LKDl....puVKMh..uSccQDHh.s...	1	4	17	21
+13021	PF13180	PDZ_2		PDZ domain	Bateman A	agb	Jackhmmer:O24877	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.68	0.72	-4.09	52	19233	2012-10-02 11:12:46	2010-08-05 17:07:01	1	162	4727	36	5564	18896	7404	86.90	22	21.84	CHANGED	uslGlphptpps..................sshl.p........VtpssPutcss.lph..............GDhIhplssptl...psh.......spLh......phlh.ptp.GssVplplhR......sscppslplpl	............................................................................................Gh..h...t.............................................................tGs.h.Vsp.............Vh.s..s....u...P...At.......cA..G...lcs......................................GD..lI..l...p..l....s...Gps..l............psh...................p.clh................p.hl...t.....p......t....p....s..G..p...p...l.p.l..p...l..h..R.......s..G...p.p.hphpl........................................................	0	1926	3646	4675
+13022	PF13181	TPR_8		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:O25864	Repeat	\N	25.00	10.00	25.00	10.00	24.90	9.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.62	0.74	-7.70	0.74	-3.77	158	8299	2012-10-11 20:01:03	2010-08-05 17:20:12	1	2662	2423	16	3530	83745	27261	32.40	18	6.01	CHANGED	h.....ps.....hh.thGpl.ahp.hsph..cp...Ahphhpculplss..s.	........................................t...hh.tlup.h..Yhp..hs.ch........cp..............Ahphhpcshph.....t...................	0	1467	2293	2991
+13023	PF13182	DUF4007		Protein of unknown function (DUF4007)	Bateman A	agb	Jackhmmer:O26600	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 284 and 326 amino acids in length. This domain is found associated with Pfam:PF01507 in some proteins, suggesting a functional link.	27.00	27.00	27.90	27.70	25.30	24.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.58	0.70	-5.58	34	141	2010-08-06 09:59:40	2010-08-06 10:59:40	1	6	122	0	41	146	81	259.60	24	81.04	CHANGED	pFuuHE...........TFslRhGWLpKuhctlp.ps....sssFh..ccsuhsphGVGpNMVculRYWhpAsplhc-s.tt.........phTphGchlh.......shDPYlE-.uoLWLlHatLsss....pstAssWYhhFN.hshsc..Fo+s-lhphlpchhsp......tpphsppolpcDlssllpsYs...............ptsphssE-.hssPhsELuLlphs..ttpt.taphshss+ssLsstllhYAllcah...s..pstpolulscLhtps....sSPG+lFpLscpslschLcplpph..stlplscTAGLcplhhpp.......phtshchLcpaY	.............................FutHETF.hRtt....WLpKuhpth..tt..........phF....tppuhs.phGVG+NMVpu.l+aWhtAssllcpstt..........phTth.Gphlh..........................shD.ahEp.solWLlHah...Lsst............tptsssWahhFN.hp..t...p..p....Fscpplhphlpphhtp.........tpt...hupsolpc.DlsshlpsYs.................ttts.E-.hpssls-Ls..Llpth..........tpt.haphtpstp.slsstlhha..ullchh...t........tstpolshpplh.t......suPGclFpLscpslhchLpplpph.....shlp.hscouGlcpl.h.t...........thlt..................................	0	18	36	39
+13024	PF13183	Fer4_8		4Fe-4S dicluster domain	Bateman A	agb	Jackhmmer:O27906	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.92	0.72	-3.94	344	10837	2012-10-03 08:56:43	2010-08-06 11:04:20	1	158	3616	30	2967	16116	5623	77.90	24	15.69	CHANGED	p.hp...pChpC.u..tCt........ss.....C...........................P...................................................hhht.................................ht....h....tttth..t...................................................................t..h.........................................................htC...stCtt.....Cs..phCP.t.....sl	....................................................................t.htpClpC.G...hCh.............ss........C....................P................................................shtt...........................................................................................................................h.s......p.h...ht..ss.pstsht......................................................................t....htt.............................................................pthhsC...ssCts............Cs.psCPhpl................................................................	0	989	2028	2572
+13025	PF13184	KH_5		NusA-like KH domain	Bateman A	agb	Jackhmmer:O27285	Domain	\N	27.00	27.00	27.00	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.93	0.72	-4.17	54	4542	2012-10-02 00:34:43	2010-08-06 11:35:28	1	31	4481	7	1040	3009	2319	69.80	50	16.41	CHANGED	sGpRsKlAVtops.....plDslGuslGhpGsRlpslspELp..............sEKIDllpascD.......ppaltsALsPAcVhsVpl	.....................sGsRuKIAVpo..p-.....ppl...DPVGACVGh+GuRVpuVssELt..............G.E+IDIl......W.....s-.-......PApFlhNA.Lu...PAcVssl..l..............	0	356	687	885
+13026	PF13185	GAF_2		GAF domain	Bateman A	agb	Jackhmmer:O27394	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-11.13	0.71	-3.71	408	8344	2012-10-02 14:34:25	2010-08-06 13:27:49	1	1430	3034	23	3170	13907	1709	140.50	14	25.15	CHANGED	sts...h.pclhpt...h....l.p..tl.hp.......hh..sphuh.lh.......lh..cppp...................thh.hs......htsht..........tht..ht.t.....................................hpptcshhhs......................tt......t.h.htt..htshl..........sl..Plh.tps...p.lhGll.s....lts....tt...................tasp.p..chphlptlupthuhulp	............................................................................................................................................t......hht......h...h...p.....h..hp......hhs..hphuh..lh.............................hh........-tpt...................thhhhs........................h.t.uh................t...........h...t...........................................................................................hpppcshhls........................................................tt.h...........t.phspptsh..p..uhl................sl....Pl.........h..t........p.....s.......p.llGlL.s...........l.su.........tph...........................ttas.p..p....-..hphLptlut.hu.sh.................................................	0	1082	2191	2819
+13027	PF13186	SPASM	DUF4008;	Iron-sulfur cluster-binding domain	Bateman A	agb	Jackhmmer:O26216	Domain	This domain occurs as an additional C-terminal iron-sulfur cluster binding domain in many radical SAM domain, Pfam:PF04055 proteins. The domain occurs in a number of proteins that modify a protein to become an active enzyme, or a peptide to become a ribosomal natural product. The domain is named SPASM because it occurs in the maturases of Subilitosin, PQQ, Anaerobic Sulfatases, and Mycofactocin.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.70	0.72	-3.63	441	4320	2010-08-06 12:57:53	2010-08-06 13:57:53	1	60	2271	0	1134	3391	1345	67.60	24	17.48	CHANGED	C.........h....hpphs....lp.........ssGsVhs....C....................s..hhtph........tlGN.l......p......p....s.lt-.......l....a.pu......pphp...ph.....+pthhpt...............................hC........p..p.............Cs	.....................................stpt.hs..lp.......ss.Gcl.hs....C..................pth.....shsph........plGN.l....pp.........p....s.lpc..........................l............h...pS......tt.hp.ph.................ppt..phtp..............................t.C...p..p..C..........................................................................	0	484	821	978
+13028	PF13187	Fer4_9		4Fe-4S dicluster domain	Bateman A	agb	Jackhmmer:O27418	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.23	0.72	-3.70	188	5796	2012-10-03 08:56:43	2010-08-06 14:12:30	1	300	2244	20	1131	20878	5640	56.40	33	18.14	CHANGED	pChs.C......t....t.....C..hps.C.........Ptthh.hhtthtthhhh......................................................C.ht..Cst.........................Ch.psCPp.ssl	.............................................................ClG...C.....t.....h.....C..hsu..C............................P.h.s..lh.....ph...s...s...t.s...s.t...h.t...............................................................................................................................cC.sh.......Csp..........................................Cs....psCPs.sA.......................................	0	435	821	1007
+13029	PF13188	PAS_8		PAS domain	Bateman A	agb	Jackhmmer:O26558	Domain	\N	21.00	11.00	21.00	11.00	20.90	10.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.55	0.73	-9.73	0.73	-3.93	488	8124	2012-10-04 01:10:46	2010-08-06 15:34:09	1	1381	2453	5	2746	38264	3152	67.80	15	10.70	CHANGED	pphps....l...hc.....shst.ulh...h............h..c......t......................lhh......sNpshtchh........G.......ht...............hhsp.h....t...........thhsthptttt..thtp....hh.........ptht	........................................hps....l.........hc.......shsp.ull.....l...............................l..D......tts...................p.................................lhh.............sNp.sst.c...hh...............G.......hs................hhsp.h..t.........thh.........................tthtthttt......................................................................	2	951	1890	2360
+13030	PF13189	Cytidylate_kin2		Cytidylate kinase-like family	Bateman A	agb	Jackhmmer:O26138	Domain	This family includes enzymes related to cytidylate kinase.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.85	0.71	-4.37	174	1110	2012-10-05 12:31:09	2010-08-06 16:01:58	1	17	600	2	300	3886	1461	168.30	26	77.44	CHANGED	lITIuRpaGSGG+pluctLAccL.Glsh....YD+.-llphsAcc.tGlscphh.pph-Epss.........psh.h.thhht...................................shshs-plaphpp...c......lIpcl.A.p.ct.ssVIlGRCAcalL+-..ps.ss...lplFlt.Ash-tRl...............cR.lhcp....h.sls.c.c.cApchlccpD+pRppa.apaYT..spcW.....GcspsYDLslsoup	......................................lITIuRphGSGGppluctLAccL.Glth...........Y..D......c....c...l....l....p.........h.....A.....c....c.....p.....G.l......s......t......p....h.....h.....pph.sEpts..............tsh....h....hh..........................................................ph.hscpl.a..ph..pp....c......hI....p........c...l...A.....p...c.....t...s...s....V..l......l.G.R.s.A.s......a.l..Lcc........hs...ps........l..p....l..a.l..h..A.s...h-hRl........................cR.....lhcp.............t...s..hs...t....c...cA.....pc..hl....p..c..p..DcpRtpa...Yphas..sp.c.W.....sc.s.psYDLslsou.................................................................................................................................................	0	141	243	275
+13031	PF13190	PDGLE		PDGLE domain	Bateman A	agb	Jackhmmer:O27741	Domain	This short presumed domain is usually found on its own. However, it is also found associated with Pfam:PF01891 suggesting it may have a role in cobalt uptake. The domain is named after a short motif found within many members of the family.	27.00	27.00	27.30	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.17	0.72	-4.30	127	379	2010-08-06 15:35:55	2010-08-06 16:35:55	1	2	367	0	183	378	172	89.10	25	37.34	CHANGED	llsulllushluhhAS............usPDGLE.shtth..........pstp-hsh.pps.....t.........u.hsDYul.s....uhsp.........................................................hGssluGllGshlslsluhuluhl	......................h.lhulllusslu.hhAS............ssPDGL..E.shpph.....................tstp.ch...sh.ttt.....t.ht...................u.hsDYul..s......Ghss...................................................lGshluGllGshlslslshslsh.h....	0	65	130	163
+13032	PF13191	AAA_16		AAA ATPase domain	Bateman A	agb	Jackhmmer:O27636	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.44	0.71	-4.30	217	4712	2012-10-05 12:31:09	2010-08-06 16:51:29	1	525	1445	1	2447	16457	2610	171.70	16	17.45	CHANGED	plhGR-ppl.....ppLtshl..t..thtpups..............thllltG.sGsGKosl......lp........p..lhpthtpp...................thh.hhpspttph.......................shtsh.tphhpplhpp...hhst...........................................................................hh....................................sshsshsssptp......................h....phlp..........ph.l.............................tthspt........pp.......................................lllhlD-lp..............hh-.....pss.........hph.lpt..L.....hpt.........hpt.....................slhll	........................................................hhGRptpl...ttl.t.phl..........t....tht.ts.ps..............................p.s...l.l...l.t...G....sGsGKosL...............lp..............................p...l...hpp..htpp.........................thh...h..hp..s.p.sspt.....................................................sh.ts..h.....tph.l........p..p...l...h..pt...............hht................................................................................................................................................................................................................................................................................................tt.hs..s.t.tht.......................................................................h................thht.........................ph...l................................................................................t.t.httt....................tt.............................................................................................................................................................................................................................................lll...h....lD....-....hp....................hhc..........tts.................hph..lt.....l...hp.............................h........................................................................................................................................................................................................................................................................................................................................................................................	0	925	1663	2175
+13034	PF13192	Thioredoxin_3		Thioredoxin domain	Bateman A	agb	Jackhmmer:O26981	Domain	\N	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.70	0.72	-4.16	112	2658	2012-10-03 14:45:55	2010-08-09 14:50:14	1	25	2065	41	788	3102	540	77.70	30	21.59	CHANGED	hcI+l..l..GsG.C.spCp...pltphscpulpch.u.lsu....plp+....l.pDhpcI..hpaGVhsTPul.lls....sclhhsGp.lPstcc.lpplLp	............................h...cs.hh...Sho..C.psCP.......sVpsh.s...h.h.u...l...h...ss....s...lpt...........shl-........s....sh..h...p-l.....pp..h.....s.lMuVPul..hl....s........G...c.........h...s..p..G+....hsh.tc..ltp.................................	0	267	506	666
+13035	PF13193	AMP-binding_C	DUF4009;	AMP-binding enzyme C-terminal domain	Mistry J, Eberhardt R	jm14	Jackhmmer:O26318	Domain	This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.82	0.72	-3.03	574	45096	2012-10-03 01:00:17	2010-08-10 11:53:00	1	1760	5076	96	14992	41390	10507	76.60	27	9.63	CHANGED	ElEssL.ssH......P....s.V..sEu...AV..lG...hs.Dp...........hpG.ptl.hAaV..lh.........................................t...pc....lpph.......l.....pp......p.lu..........shthP.p...lhhl...s...LP+TpoGK	..................................................ElEssL..hp.a............P......s..V.....t-u.......s.V................lu............hs..ct...................................hhG..ctl...hAal..lhpt...........................................................tshpt......pp........lppa..........l........pp............p..Ls......................sat..hP.........hta...l.......s.........LPhTssGK...............................................................................	0	3967	8666	12279
+13036	PF13194	DUF4010		Domain of unknown function (DUF4010)	Mistry J	jm14	Jackhmmer:O27500	Domain	This is a family of putative membrane proteins found in archaea and bacteria.\	 It is sometimes found C terminal to Pfam:PF02308.	30.00	30.00	33.10	33.10	29.80	29.50	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.37	0.70	-5.03	138	426	2010-08-10 12:49:28	2010-08-10 13:49:28	1	3	381	0	187	409	49	207.30	28	50.08	CHANGED	VlluuloasGYluhRhhGs+tGlhloGlhGGlsSSTAsThshucpu+p.pss......hsth..hsuulllAsssMhlRlllls.sllss.s....lhh.tLh..hPhhs..hslsshssuhhh..h+p.......tttttt.ssshs....pNP...hpLpsALtFuhlhsllhlhsphhpphhG.ssGlhhluhluGlsDlDAhslSlsph.hsss.plshssAshulhlAshuNslsKssluhhhGs	.....VlluuluahuYlshRhhGscp..GlhloulhGGlsSSTAsshshucpu+p..pss..........sth.hsuuhllAss.sMhlRhl...lll.sllss..s........lhh....tlh...hshhs..hslssh.shuhhh....h+p...........ttttts...stphp.....pNP.hpLpsALhFuslhsllhll....sphspphhG.suGlhhluhluGlsDlcAhslolsph.tsss..plssssushulhlAhhuNslsKsshuhhhG.....................	0	54	131	166
+13037	PF13195	DUF4011		Protein of unknown function (DUF4011)	Mistry J	jm14	Jackhmmer:O26588	Family	This family of proteins is found in archaea and bacteria. Many members are annotated as being putative DNA helicase-related proteins.	22.20	22.20	22.70	22.20	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.10	0.71	-4.25	100	425	2010-08-10 13:28:15	2010-08-10 14:28:15	1	28	396	0	147	436	75	172.30	23	10.16	CHANGED	cLLDLohR.NpLLNhp...tspp.slplhsss.....ssplt-h..L.sp......upshphhs......hsp.t.....................................ts.p...stthhptpshp..........chttph....htpth......................pcpplh....................................................stlstppL...pp+..LhpLappA+ohh-EsGsNsLYLAlGhLcWhc.spps....cp.hhAPLlLlPVpLpRp...sspp.....sapl..phps--.hthNhoLhphL	......................................................................................................................pLLDhsh.R.Npllsh........stp..sl.lhs.t..........s.l.ph..l.tp......tpthphhs....h.t...................................................................................................t.........t.p.....................p...t.......tth...................................................................tpppl.................................................................................s.h.st.ppL.....ppp...LtpLhcpu+shhcEsGsssLaLAlGhLcWhc...spss......scshhAPLlLlPV.pLp+p..ssts.....tapl...phc.p--..sthN.oLhphL........	0	62	95	120
+13038	PF13196	DUF4012		Protein of unknown function (DUF4012)	Mistry J	jm14	Jackhmmer:O26332	Family	This is a family of uncharacterised proteins found in archaea and bacteria.	28.00	28.00	33.00	31.40	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.70	0.71	-4.04	44	176	2010-08-12 09:26:21	2010-08-12 10:26:21	1	3	119	0	73	178	61	143.00	31	24.84	CHANGED	cGsRsYLlhsQssAEhRusGGlsGuhullps-sGplslsc.h..tsssch....htpssss.hss-pts..has.....t.shhhpDsshsPDFspuAphhpphWppps...Gt.slDGVlulDPVsLshlLpss.GPVsl..s.DGp..........slsusNsschlhsssY	....sGsRsYllhsQssuEhRuoGGllGuhuhlss-sGplslsc.h..tsssch.......hspsshs....hssc..ptp...lau..............hthsh.hpssshsPDFspsAphhpshWptps...sp.slDGVlulDPVsLptlLtss.GsVsl..s..DGp............slsusNssphhhsssY........................	0	22	51	61
+13039	PF13197	DUF4013		Protein of unknown function (DUF4013)	Mistry J	jm14	Jackhmmer:O27260	Family	This is a family of uncharacterised proteins that is found in archaea and bacteria.	26.90	26.90	27.10	27.30	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.40	0.71	-4.92	99	205	2010-08-12 09:39:34	2010-08-12 10:39:34	1	1	98	0	137	208	21	168.40	18	63.89	CHANGED	lllssll....hlsllshhllhGYhlclh+ps....hst.pshPc...a.s..sasphhhcGlhh....hllsllahllshllhhlhhhhshh...........................s..hh.........slhshhhsh....lhhllsllhuhh.hsh....uhspautps.phssuFphsplhphlp...hhhhta......lhshll.hhllshlhshlsslhhhl	......................h.hlhhll....hlsllshhllhGYhhclh+ts....hs..sthPc...a.p...sasphhhcGlph....hllsllYhllshllhhlhshhhhh.................................s..hh................hl...hsh..hhhl......lsh.llsllhshh.hsh......uhsphutps.phtuuFphpplhphlp.t..hshhpa.......llshll.hhllshlhshlhhhh...h..............................	0	37	99	126
+13040	PF13198	DUF4014		Protein of unknown function (DUF4014)	Mistry J	jm14	Pfam-B_4873 (release 24.0)	Family	This is a bacterial and viral family of uncharacterised proteins.	23.00	23.00	23.70	23.50	22.20	20.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.41	0.72	-3.57	5	132	2010-08-12 10:49:27	2010-08-12 11:49:27	1	1	102	0	1	55	0	70.70	74	91.89	CHANGED	Ms+ha+K+YPRKSRsTEFLFLILFIVLM..lPISPLIllWlIG+..........................IlEhVIELYsDVVWuSFNsLHNKINPY.......KEN	.....MsphhcKpYPRKSRsTEFLFhILFIVLM..IPISPLlhVWhIGK............................IIEPVIELYsDVVWASFNTLHNKINPY.......KEN....................	0	0	0	1
+13041	PF13199	Glyco_hydro_66		Glycosyl hydrolase family 66	Bateman A	agb	Pfam-B_3959 (Release 24.0)	Domain	This family is a set of glycosyl hydrolase enzymes including cycloisomaltooligosaccharide glucanotransferase (EC:2.4.1.-) and dextranase (EC:3.2.1.11) activities.	23.70	23.70	23.80	23.70	23.60	23.60	hmmbuild  -o /dev/null --hand HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-12.87	0.70	-6.11	25	143	2012-10-03 05:44:19	2010-08-16 13:58:58	1	19	112	3	25	168	3	475.00	26	70.15	CHANGED	sTDKApYpPG-.sVphslshpss.......ussplchpHLs.psltpp.phshtht.spshs.....WpsPssDF...pGYhVclhs.ppssstlspsshAlDVSSDWs+FPRYGalus..Fsss...........s.pphpppl-pLsc.aHINulQFYDWta+HcpPlstss..tp..psWsDhu......s.RplttpsVKshIstsHphGhtAMhYNhlYGuhpshtp............sGlp.-....Wtlaccsspt......p.-pasL.....sp.h.ss..lhlhs.PsNssWQsYlhsptscshcphsFDGaHlDQlG.sRusl.a.......shsGpsl..........p..................LsssausFlpshKptl.sstp.........LVhNsVssautpplus.ushDalYsElW............tspssYssL+phlcp.....scph.sps.....upssVlAAYMsa...........................................................stus.ssGt.................................................................FsTsuVLLsDAsIFAuGGsHlEL......G-........phLspEYFPspsLphs.ccLpcphhsYYDFlTAYENLLR.....DGtsp....sssshsssstph.Shs....................sptspVWshuK.cssstc..llHLlNhhGss..shsW+c........ssuspspPpphpslplpl........ptss.plppVahASPDh.tsGsspcLsFpp....sGs.V..pholPpLpYWsMlhl	................................................................................ssKuhYtsup.pV.hphp.t..............hthphphhhht..phltp...ht.....ttph...........hp.Ptpph...pGYhspl.h..ttspth......tshulsVssshtpFPRYGalus..a.pp................tp.tttht.hpp.hplNsh.FYDhh.ctp............Phsts................................tpa.sh.......t.ppl.hpsl+phlpth+phGhhuhhY.shhh.us.ps.h.p.............tsst.p....hhlapsssp...............t..thsl.....st..h..s.....hh...hhs.Psstp.WQpYlhpp.ppshpphuFDGaphDplG...ppssh..h.......shs..up.h.............................lppsassFlpshKpth..sh..........lshNsVst.s.pplst.....up.DhhYsElW.............t.pstatsLpthltp....stth..............thshlhuAYMphtttt...............................................................................................................................ttt.hppsuhlLssAshhA.GG.Hhpl............Gp.........thLtptYaPsps.hphs.pphppt.hhpY.pFlsuYpNlLp.....Dsthp....t.s.phshsshth...uhs...................sptsplhshsK..ps......sshp......hlphlNh.shs....s.sW+s................us...pPth.pphtlph.........htt...spplahsSPD..t........tut..plthp......pst.l...hslPpLphWsMlh........................................................................................................................................	0	12	19	24
+13042	PF13200	DUF4015		Putative glycosyl hydrolase domain	Bateman A	agb	Pfam-B_597 (Release 24.0)	Domain	This domain is related to other known glycosyl hydrolases suggesting this domain is also involved in carbohydrate break down.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.04	0.70	-5.52	62	311	2012-10-03 05:44:19	2010-08-16 14:08:57	1	12	292	0	87	459	246	298.50	31	62.60	CHANGED	GlYlouhsuus.pt.h-cllchlcpTcLNuhVIDlK....-DpGplsapp.psstspthssspsh....hDhpthlccL+ccsIYsIARlVsFK.DshLAct.....+P-huh.ppssGslWpstpu.....u.........alNPapc-VW-YNlslAccAAchGFDEIQFDYlRFPs.....pt.tcpLpastsshpp.......................................................................+ssAIssFlthA+-cL.pshsV.lSsDlFGhssts....cssuIGQshppluppVDhISPMlYPSHassG................aGlc.pPDtcPYclltpuhpptpptlsth........tshhRPWlQsFTssaltt..hhpYGspplcsQIcAltDs..GhspalLWNAuNpY	...................................................................................................ulYlouhshss..p.h.hcphlchhcpotlNuhVIDlK....sDpG.lsa.s.pst....h..s...p.t..h.....s..s....spsh..............hD...h.tt.l...lcph+cpsIYsIARl....V...s.F.......K......D.sh.Lu..pt................pP..-.hul.....pptsG..p.h....Wp..s..tps..........s.....................W.lsPapc.csWcYN.l....s.lA.c.E....A.A.c.h..GFDEIQFD.YlRFPs..........tt.sppl.pa.s...tsptp...p...................................................................................+ssAIssFLphA+.cc.L..t...h..s..l..lSsDl.F.Ghsshs....sstu...IG........Qphpt..l..u..p.....VDhISPMlYPSHas.uh...............huhp..PstcP...Yphlhpuhtcstphh..tt..................tshhRPWlQsFpsshhtt...h.Ys.pplctQlcAhp-t..shstahLWNusNpY.....................................................................................	0	43	66	74
+13043	PF13201	Xylanase		Putative glycoside hydrolase xylanase	Coggill P	pcc	JCSG_target_393205	Family	This is a family of putative bacterial xylanases. Comparative structural data from TOPSAN indicates there to be a C-terminal carbohydrate binding domain similar to those of carbohydrate enzymes such as glucanase and xylanase. There is also structural similarity of the N-terminal domain, according to TOPSAN, to endo-1,4-beta-xylanase (from Streptomyces sviceus) and beta-xylosidase (from Magnetospirillum magnetotacticum MS-1). The N-terminal domain fold is an immunoglobulin-like beta-sandwich.	20.90	20.90	20.90	20.90	20.60	20.80	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.04	0.70	-5.62	30	518	2012-10-03 05:44:19	2010-08-16 14:49:09	1	35	171	3	105	458	18	216.30	18	43.09	CHANGED	oSCI+-EA.NAEADIp....u..s......psssshLhp...........ps.hssspIplhV..pp.ssDloplAPpFsLTsGATI........sPs...u......G......os.p......D......Fos...Ppp..............YTVTSEDGpWc+sYpVsh....hsspl....s.o..pacFEslpht.........p.t.cYplaY.-h.psuspp.....hp..WASGNsGFplouhu.p.ssp-YPTsQsss.G.hpGKClK.LsT+STGshGuh...l..tMP.IAAGNLFIGoF-ls.sAlsssLKAT+FGhPFp+..cPhpLsGYYKYKAGcpap....-.s.Gp..l....ss+KDpssIYAVhYEsscsst..........h.LDGs....Ns..hT..usp..lVulAcl..s..-s+E.........T..DpWTcFslPF.h.p.GKsIDts+LppGcYsLAIVFSSStcGupFcGAlGSTLaIDEVcLI	.........................................................................................................................................................................................................................................................t....t..t..p..l.h.l.............ts...s...l.pt.h....s.h.t..hs.......s..Aol............t.Pt..s......s......s.........................sasp.....t..............apVsuts.....t.th...p...Yp...lph.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	40	93	105
+13044	PF13202	EF-hand_5	EF_hand_3;	EF hand	Bateman A	agb	Jackhmmer:O26668	Domain	\N	25.30	11.50	25.30	11.50	25.20	11.40	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.82	0.73	-7.13	0.73	-4.38	149	5306	2012-10-02 16:17:27	2010-08-17 09:27:41	1	515	903	68	2797	37229	2719	23.80	30	8.51	CHANGED	lp.s..hFp.thDhstDGpIshpEh...pp..lh	...........h....hFp.thDt.s.tD..Gp.lohcEh.........h.............	0	1041	1668	2149
+13045	PF13203	DUF2201_N		Putative metallopeptidase domain	COGs, Finn RD, Sammut SJ, Bateman A	agb	COGs (COG4900)	Domain	This domain, found in various hypothetical bacterial proteins, has no known function. However, it is related to Pfam:PF01435.	23.20	23.20	23.30	23.30	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.95	0.70	-5.24	16	492	2012-10-03 04:41:15	2010-08-17 13:36:00	1	4	403	0	173	512	550	212.40	15	53.68	CHANGED	phppRhstAlt+hlEstPhhuuLsLhhphp-..ucsh......................tsstTDGc.plaYsPsF....-sLslsppVGllAHEVhHlALcHstRttsht......hD.plaNhAuDuhINssLlpsGa.tLPtsslh.pp.............csshtsasAEclYptl.........................tt.ttttuttptt..sputppstpppscu............t.hthssGtps-hsstsputussEttstput..cWpppltcthptG+usGph.utLtchls-hspsthP.WcplLRshls+slpc.s...chSWpRPsRRalu...........pssa.Pu.hp	......................................................ht.........................hhs..h..h.th.........s.th.........................s.h....ts....c...uh....hlhhsPthh......th...s........p...p...h..t...t...l...l....hH-lhHhhhtH.h..hRt.tt....................................hst.hhshAsDhs...lN...p.h....l.......p....t.h...........h..Ptshh..........................................................th.sEt....h.h.t.l...............................................................................................................................................................................................................................................................................................................................................................................................................t..............................................................................................................................................	0	70	126	158
+13046	PF13204	DUF4038	Hydrolase_6;	Protein of unknown function (DUF4038)	Coggill P	pcc	Jackhammer	Family	A family of putative cellulases. 	22.60	21.70	22.60	22.00	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.75	0.70	-5.08	28	345	2012-10-03 05:44:19	2010-08-17 13:38:46	1	8	222	4	120	308	23	264.50	24	58.13	CHANGED	spRaLhppsGpPFFaLuDTuWthhp+lsp..--hchYLcpR+ppGFNVIQhssLsph-uh....sh.sphsh..tpp.th.....thN..........sYa-HhDthlchAspcGlhlulVslWssts..st.h..........sslhsh-pAcsYu+alspRYcch.NlIWllGGDs............csspthchWpulupslpptsst.......LhTaHPpGp...pssschFcsp.WLDFpMaQSGHpp..psp...............s.hphl..phshpppPsKPllDuEPsYEshshshps........passhDVR+tuYhulhuGu.sGhTYGspuIWQah	...............................................................................t..+hht..tsGpPahhhu.-TsWthh.....p.phsp.............p-...h....phY.L.psppcpG.FNslphslls......p...h.s...h......................sh.s.....h...sh....t..................................hshtthN.........................................sYFc+h-hhlptstphGlh..s.s.l..l.h..a..s.s.h....t...tWh.....................shhs..-p...sptYscalspRatsh.Nl.l..Wh.luGDh.............................sptshphap.thsp..slp.........ph...sstp..............LhohHspsp.........ts.sph.......h...........psp..shlshshhQo.uHtt...tt..................s.hth.l.....t....p.ptt...hKPVlssEs.tYEs.h...........hshts..............hss.-lR+t.sa.ulhuGu...s..GhsYGtpslhph..........................................................................	0	57	94	107
+13047	PF13205	Big_5		Bacterial Ig-like domain	Bateman A	agb	Jackhmmer:O26670	Domain	\N	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.86	0.72	-3.44	269	1557	2012-10-03 16:25:20	2010-08-17 15:32:03	1	286	641	0	798	1779	1039	104.70	19	16.89	CHANGED	DsssP.sls..us.sPsss....us...sl..ss..ss..............slslsFsE.sl....pssshstshhh..............ssstsssls....s.s...................hsu.psl..slsPs..............ss.Lsss.TsYslsl.....ssu......lp.....Dhs...G..s..........h...............shs...a....sFoT	..............................................................................................P..tlh....sh.sPsss......us......sV.....ss..st...................sls...ls.Fsc..sl.........shssspts.l..hh.....................................ssssshslshp.........................................hsu..ppl..sls.Ps..............ss.Lpss.....o.....s...Yslsl.........ssu.....lp......Dhs..G.....s..................................shs...hsFoT....................................................	0	256	541	758
+13048	PF13206	VSG_B		Trypanosomal VSG domain	Bateman A, Jackson A	agb	Jackhmmer	Domain	This family represents the B-type variant surface glycoproteins from trypanosomal parasites. This family is related to Pfam:PF00913.	25.00	25.00	25.00	25.00	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.42	0.70	-5.32	132	958	2010-08-18 11:04:25	2010-08-18 12:04:25	1	4	12	0	708	958	0	291.60	15	75.39	CHANGED	hhlhlhhhs................ssusssssp......................Ntt-FpsLCp...llp.....luptt.....hp.st.sp...psssthpplt....tlNhohusss....ahp.h.ptttttp.ttt..tt.t..................ttWppsttthpp.ttp..........................................................t................thtphshpthsstttpthp................pltppAtplhpphp..ptttpttsss......thppt....lpp...AlYGsssssssst.............hssssspsss............C...........stsssssu.polssslhCLCssss...........................................................ssssphCspt............sssssshtssss...sspssap.pltstC...sttsssplT....ssplpsslt.h..........sthppttsssssphhLGp..........tssssCsG.s.....ssuhC.VpYsshhsst.....shsslsWlppLppAsppLpptppsptptpp.........htp.plptl	.....................................................................................hh.....................................................................................................................................................................................................................................................................................................................................h...h..h.tt.t...........t...tt.......hcpt...............htp.....sla.Gptssts..p...................................................tththsss....+sts......................C..............tsttsp...t....s..G...colssDhhCLCssss...................................................................................tpstpphCstt...................tsttt.s.h....t.s.s.t.t...................t.h.......pp.....s.....Wp..p.........lp.ptC....pttpp..t..h.p.................tplpphl.tph.........................tthhpt..tp.p.p.t.p.........t.....t.......h.h..LGt..................tptts.....CsGpp..................ssshC.V.Yttp...t.....................ttttlsWhpcl.ppuh.p..p.hpp.hpp..ttp..pt......................................................................................................	0	622	708	708
+13049	PF13207	AAA_17		AAA domain	Bateman A	agb	Jackhmmer:O26135	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.06	0.71	-3.29	412	3187	2012-10-05 12:31:09	2010-08-19 09:37:34	1	91	2065	29	1073	22418	10222	153.40	15	55.53	CHANGED	hlhls.G.ssGuGKoTluptL.....uc.p...............h..........s........h......h...l..phss.....................ht..shh.tht..pt....................t..p.....ph.......lpph.......................hhhcs.........................................................h.cht..tss......phlhhs...................hsh...........sttt......hhp..c.............................................cshsp	.........hlhlh.G.ssGoGKo....TlA....ppL....................up..p..............................................h..................................s..................................hs....................h.............l......chDs....l.h................................................ht...sht.....tht.....pt.........................................................................t..h.p.......................ph..............lpt................................................................hll-G..........................................................................................................ht.............................hhhh.............................h..................................................................................................ttthtt.h......................................................................................................................................................................................................................................................................................................................................................................................	0	356	664	893
+13050	PF13208	TerB-N	DUF4016;	TerB-N	Anantharaman V, Aldam G, Mistry J	gba	Anantharaman V	Family	The TerB-N domain is found N terminus to TerB, and TerB-C containing proteins [1]. It has a predominantly alpha-helical structure and contains an absolutely conserved glutamate [1]. The presence of a conserved acidic residue suggests that it might chelate metal like TerB [1]. These proteins occur in an two-gene operon containing an AAA+ ATPase and SF-II DNA helicase suggesting a role in stress  stress response or phage defense [1].	25.00	25.00	38.00	38.10	24.80	23.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.56	0.70	-4.89	152	214	2012-10-09 17:40:07	2010-08-19 12:01:53	1	12	206	0	57	217	8	206.60	24	30.87	CHANGED	Psc.hhphtshth..s.....................hh......u....................ht...sp.....-tsalptuh.h.As....sshsht.hshh.sYaPoYpslospp++uYhsWhupsRps.........ssssluYlFlahYtL.pplhl-ss......pcsht.tlhp.hpch............lshY...........hppah.pshl...hhhsl....s..........................hpph..........hhh.p...s...............................................pp.....hutc.shthhhsLuphhhc..pssl.........................schshhhst.sh.pltt....+ps	...............................tphhthtthhh.s.......hlu...............ht..sp...-tsFlp.uh.lAs.....sphsht.hshh.sYa.PoYsslospp++uYhpWhupsRps.........ps.sluYlFlahYtL.pplhl-ss......pcphstlhp.hp+h............lshY......hppahpshl...hhhsh.st..............hpch.........hhhp.s............................................pp..tutc.shthhhsLuphhhcppsl..........................schshshshsh.tlt.....................................	0	16	35	45
+13051	PF13209	DUF4017		Protein of unknown function (DUF4017)	Aldam G, Mistry J	gba	Pfam-B_2009 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	21.10	21.10	21.30	91.40	20.20	20.50	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.05	0.72	-4.18	15	75	2010-08-19 11:03:21	2010-08-19 12:03:21	1	1	75	0	4	26	0	56.90	82	94.07	CHANGED	MKNIlPALllYIIVClIAhIlPAS-GYNpVGWKLFVGQAYAIPIFlITAIITFYINKKKS	MKNIhPALllYhIVClIuhIhPASpGYNalGWKLFVGQAYAIPIFlITAIITFYINKKKS..	1	1	3	3
+13052	PF13210	DUF4018		Domain of unknown function (DUF4018)	Aldam G, Mistry J	gba	Pfam-B_2010 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 190 amino acids in length.	25.00	25.00	162.40	161.90	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.26	0.71	-4.92	6	74	2010-08-19 11:48:07	2010-08-19 12:48:07	1	1	73	0	3	66	0	186.50	77	56.30	CHANGED	hpKKsTGFllLhllQIIuCShFLsFSllGoILLPLFFFIVHAhssGhPVQKSLGuIlWFVVSAIFYA.PFPPLWKLlLLsLHIhlTFWLTGuNRNQQLlRFlSIITIGlhShLll.lFPYIRLlhSYlhphVALGFGYAlpPLhSAApLKDT--hWpNKGpLtcspIc-ss.p...FDPhllNSITIIlhTsIAl	...................................MpK+TTGFVILLlhQIlhhSlFLPFSLFGTIhLPLFFFIVHVVGPGYPVQKSLGGIVWFsVSAIFYA.PFPPLWKLLLLllHIMITFWLTGANRNQQLLRFsSIITIGlMSILIVQVFPFIRLIFSFIsEVVALGhGYAlNPLlsAAELKDTEDVWANKGHLLKPpIEDs+t...DFDPTLINSITIIsCTAIAI.......	0	0	2	2
+13053	PF13211	DUF4019		Protein of unknown function (DUF4019)	Aldam G, Mistry J	gba	Pfam-B_2012 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 130 and 183 amino acids in length. There is a single completely conserved residue E that may be functionally important.	22.10	22.10	22.10	22.40	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.24	0.72	-3.77	34	143	2010-08-19 11:48:56	2010-08-19 12:48:56	1	4	124	0	45	144	12	100.90	29	57.03	CHANGED	puAppalpLlDsGcas-sWcpAushh+stlspcpWsstlpssRts.LGsltsR..phhstpthsshsssPcGpYsslpapTpFsstts..shEplohhh-pDutW+lsGY	................sA.phhphlDus.....phsphWp.sAushh+stlsp.s.tasspltstRtp.LGslhsR..t.lsth.phs..sh.sshPsG..YsslpasTpFspssp...shEplohph-pDstW+lsGY.............	0	10	24	33
+13054	PF13212	DUF4020		Domain of unknown function (DUF4020)	Aldam G, Mistry J	gba	Pfam-B_2014 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 176 and 195 amino acids in length.	21.60	21.60	22.60	21.60	21.20	20.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.00	0.71	-4.70	10	80	2010-08-19 11:50:41	2010-08-19 12:50:41	1	2	80	0	5	73	0	175.10	70	16.29	CHANGED	VFIKCVLYWE..........................QKTDWLYPLLlpEsEEsKIKFMpaLCYYVKTLSs+EQQKFWsAWLusFLRERP..KMGsI....TsREYVMlLRhlLaMDEVhEKGLpll.ppF.sVpGcssptEhKQLahchLcKcEphKtahEhYAslFFhLLQsspEAshhEsEIIQIK-hLspapV-+clLshIcNEh	......................................VFIKCVLYWE..........................QKTDWLYPLLIpENEENKIK.FMQFLCYYVKTLSsKEQQKFWsAWLSlFLRERP..KMGtI....TAREYVMLLRIILaMDEIlE+GLsIls+uFSsVpGK.ssppEhKQLahEhLcK.pEShKhaKElYANVFFhLLQThQEAsLhEsEIIQIKELLltYcVEcpVlphI-NEI....................................	0	2	3	3
+13055	PF13213	DUF4021		Protein of unknown function (DUF4021)	Aldam G, Mistry J	gba	Pfam-B_2025 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved YGM sequence motif.	25.00	25.00	29.30	29.30	19.20	18.30	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.47	0.72	-4.33	5	82	2010-08-19 11:51:21	2010-08-19 12:51:21	1	1	81	0	4	36	0	45.50	80	77.05	CHANGED	K-NspcNsTsIpNNNTsNLslEEQAMNGLYGMPETsIEDADHAcT-	.............KENVTENsTsIQNsNTANLsIEEQAMNGLYGMPETsIEDADHAts...	0	0	2	2
+13056	PF13214	DUF4022		Protein of unknown function (DUF4022)	Aldam G, Mistry J	gba	Pfam-B_2027 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 85 amino acids in length.	25.00	25.00	79.30	79.20	21.10	19.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.78	0.72	-3.88	9	74	2010-08-19 11:52:15	2010-08-19 12:52:15	1	1	74	0	3	36	0	75.30	92	97.18	CHANGED	MLLSHIMtMDaIMSIlTLALLLLAElLVAIILIGVSIEICSYGWKKSNGIKYSCLLLSLLLGTASILGLhAAPAYFFIQLTEK	...............MSIlTLALLLLAEILVAIILIGVSIEICSYGWKKSNGIKYSCLLLSLLLGTASILGLhAAPAYFFIQLTEK.	0	0	1	1
+13057	PF13215	DUF4023		Protein of unknown function (DUF4023)	Aldam G, Mistry J	gba	Pfam-B_2030 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved KLP sequence motif.	25.00	25.00	34.40	34.10	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-7.66	0.72	-4.18	6	106	2010-08-19 11:53:06	2010-08-19 12:53:06	1	1	106	0	13	35	0	37.50	69	92.19	CHANGED	MpsTp-FV-Kl+EsQuKsc+N+c+QGpGsPu+KLPNKQ	...MSNSN-FLDTLHEKQAKDEQNRKRQGNGNPAKKKPNKT..	0	3	10	10
+13058	PF13216	DUF4024		Protein of unknown function (DUF4024)	Aldam G, Mistry J	gba	Pfam-B_2031 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved RDE sequence motif.	25.00	25.00	93.50	93.40	21.20	17.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.68	0.72	-4.15	6	71	2010-08-19 11:53:56	2010-08-19 12:53:56	1	1	71	0	2	7	0	35.00	97	94.59	CHANGED	MVGLSVTKlHLFRDENVNFLFCIEFMQKNELLLTH	MVGLSVTKlHLFRDENVNFLFCIGFMQKNELLLTH	0	0	1	1
+13059	PF13217	DUF4025		Protein of unknown function (DUF4025)	Aldam G, Mistry J	gba	Pfam-B_2033 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved EGT sequence motif.	25.00	25.00	33.60	33.40	23.30	22.40	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.76	0.72	-4.12	17	126	2010-08-19 11:54:36	2010-08-19 12:54:36	1	1	126	0	18	64	0	51.10	49	81.61	CHANGED	Kpppppt.p.lAscpasssshcsss.h.tuLAhTHEQVSDsYtEGTI-shlpcpsp	..........................KQpNKQslp.stpQs.YTScssssup......SVhcEQISDTlAEGTIDsKLs+tS........	0	5	10	12
+13060	PF13218	DUF4026		Protein of unknown function (DUF4026)	Aldam G, Mistry J	gba	Pfam-B_2037 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 450 amino acids in length. The family is found in association with Pfam:PF10077.	21.30	21.30	21.30	29.50	19.50	20.70	hmmbuild  -o /dev/null HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.87	0.70	-5.56	11	104	2010-08-19 11:56:37	2010-08-19 12:56:37	1	3	104	0	8	85	0	295.70	54	65.82	CHANGED	EKcsSpMVAlPuoclTht.LEQRLEp.QThaT-G-IsYhs-t..suFFapC++s-c-L+FalpLsEsDs-.pI.pPYauTDslosELhAcAsAssQ-lhlEsLFps..cPLssYhQQLphlphLsPDLLLulD.SAAGKVhTREWlpFQLEs.DLhP-I-SLYVIHAVYDs-.......E-ssPThYWFHTHGLsRCGLoEsElIIPp.IuSYYGIPDLFpoFVNNuIpNGQIsFNEPIhIGQTpsGhEYLVAVPFEEGLcHVGpSTPlDsL+PLEEMpachpsss.pspFLGDhsDRDEhHQcPSVMLFRsspEpPhLESFFKGaEEQsAhMFhRT	............................................ERHFSDMIAVIPTRI...T..I.EQLKQRLEsIATKVD.-LKI..V....Y....SDE........TSLIVEL.....HMc...-plIPYELHIDEs.s.D..PE.EY...KhYNRQDoT.IVDRsFED.A.AaGTEIFTRT..LFVG....DVL-CFFQQLQFLWNLAP.DLLFVIDSSAAMKVISRsYIE.YHVEN.ELLPDIPDLYVIHSVYEDD.......K-uEPTQYWF.HTHGLLRAGVTEIELI.IP..N..R...ISSYYG..IuDLFQTFANNAVE.NGQVP.MNEPIVIAHSQQG.SIH.TVA.VPWEKGLSYIGHKTshDQLSSIE-EEVKLQPIsAQNTFLGGMDsRD.EYHQSPSVLLFKhsTSEEh.IESF.FKEHEEATGLMFYKT.....................................................................	0	2	5	5
+13061	PF13219	DUF4027		Protein of unknown function (DUF4027)	Aldam G, Mistry J	gba	Pfam-B_2038 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved CLGGF sequence motif.	25.00	25.00	30.40	69.60	24.90	16.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.28	0.72	-7.64	0.72	-4.52	13	86	2010-08-19 11:58:14	2010-08-19 12:58:14	1	1	75	0	2	42	0	36.00	77	90.50	CHANGED	MKuhQNLSYSQGVoLICLGGFsuSVsLAllIKhhpQ	MKuhQNLSYSQGVoLICLGGFAASVTLAVlIKlhHQ	0	0	1	1
+13062	PF13220	DUF4028		Protein of unknown function (DUF4028)	Aldam G, Mistry J	gba	Pfam-B_2040 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 67 and 93 amino acids in length. There are two conserved sequence motifs: IVKI and YVKKWF.	25.00	25.00	88.70	88.60	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.19	0.72	-4.33	12	74	2010-08-19 11:58:51	2010-08-19 12:58:51	1	1	74	0	2	39	0	64.00	92	87.78	CHANGED	MIVKILKDSSNSFLCTVQNKNG-pYVKKWFpKpcNpEELGRPTFKEVEKDWKENRESFMYPNlKA	MIVKILKDSSNSFLCTVQNKNGDQYVKKWFRKHENNEELGRPTFKEVE+DWKENRESFMYPNVKA	0	0	1	1
+13063	PF13221	DUF4029		Protein of unknown function (DUF4029)	Aldam G, Mistry J	gba	Pfam-B_2041 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 119 amino acids in length.	25.00	25.00	170.80	170.60	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.16	0.72	-3.61	10	73	2010-08-19 11:59:44	2010-08-19 12:59:44	1	1	73	0	2	37	0	94.80	90	89.30	CHANGED	MTKIELMALFLGYVFIFSNLNRIQEQSILEICIFSISIELFSIVSIVLLNELFphIHSFELhKFGNlVLQVICAYIVFVVLDKIlGQQTVFQDpRK	MTKIELMALFLGYVFIFSNLNRIQEQSILEICIFSISIELFSIVSIVLLNELFpWIHSFELMKFGNlVLQVICAYIVFVVL-KIVGQQTVFQDNRK	0	0	1	1
+13064	PF13222	DUF4030		Protein of unknown function (DUF4030)	Aldam G, Mistry J	gba	Pfam-B_2044 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 197 amino acids in length.	21.60	21.60	21.60	45.10	21.50	20.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.71	0.71	-4.48	6	71	2010-08-19 12:00:24	2010-08-19 13:00:24	1	1	65	0	1	48	0	136.00	73	72.54	CHANGED	sDpsRpVDLEIADT.s.oSclKp-INpQLKNQsI+PYTINlsQRsMcIVKpEpRWscVhuoIh--lFsKNGYKGFuIp.hNhEusQPhslsIpTpIssuDsGAKEFGcKIEKElsslLKTcclpKWI-sDSYTIEIYSpDpQK	..D-KpRhVDLEIADSEN.uNEIKKEINKRLQIQGIhSYKVNISQRN+EIVNAE+RWpLVFGQIFDDVFRKNGYEGFGIQQINYKKNQPVTIDIKTKIsDDEVGAREhGQKIEKEVEsVLKTEAVKKWIENDSYAIGIYDI-sR.....	0	0	1	1
+13065	PF13223	DUF4031		Protein of unknown function (DUF4031)	Aldam G, Mistry J	gba	Pfam-B_2059 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 91 and 130 amino acids in length. There is a conserved HYD sequence motif.	25.00	25.00	25.10	25.10	22.90	24.60	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.73	0.72	-3.83	53	158	2010-08-19 12:01:13	2010-08-19 13:01:13	1	2	152	0	76	163	23	81.10	42	63.48	CHANGED	VYlDsstaP....h.+GphWuHLluDo.....h-ELHAFAs.plGlscRsFpp......-HYDlstpp+scAl.shGAlsls..sR-....ls+RLpsuG	......VYlDsstaP.....h.+GphWuHLluDs.....h-ELHAF.As.plGlsR.RuFpp........................-HYDlPspchs.cAl.thGAltls..p+c....Ll+plht..s...............	0	22	48	68
+13066	PF13224	DUF4032		Domain of unknown function (DUF4032)	Aldam G, Mistry J	gba	Pfam-B_2062 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 170 amino acids in length. The family is found in association with Pfam:PF06293.	22.30	22.30	22.30	22.40	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.95	0.71	-4.54	44	312	2010-08-19 12:02:02	2010-08-19 13:02:02	1	7	304	0	87	228	135	157.30	46	36.80	CHANGED	cpLWsELTspEsFsssEp.WRlppRIcRLN-LGFDVuElplpost..sGsplplpP+VVDAGHHpR+LhRLTGLDVpENQARRLLNDL-saRAs.......stpshs-phsAHcWLs-VFEPslculPt-L+uKLEPAplFHElLEHRWaLSEptG+DVshtEAlpSYlcsVL.	..............................pLWsELTst-pFsss-h.apl-pRlcRLNsLGFDVuELclpTss.........-GpclplpP+VVDAGHHpR+LLRLTGLDspEtQAR........RLLNDL-saRAp...................sshpsh-.plsAHcWlsElFEPsVptIP......E.....l..p....p...+....h....Es...AQhaHEVL-HRWYhSp+tt.+-VshsEAspuYlcslL........	0	35	64	80
+13067	PF13225	DUF4033		Domain of unknown function (DUF4033)	Aldam G, Mistry J	gba	Pfam-B_2072 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 80 amino acids in length.	21.40	21.40	23.30	31.30	20.50	18.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.13	0.72	-4.37	27	109	2010-08-19 12:02:47	2010-08-19 13:02:47	1	3	33	0	82	111	5	84.10	49	32.97	CHANGED	WLhGPsc.lpph-..................tptsuVhlcKCRYLEpSsCsGhClNhCKlPTQsFFccchGlPLpMpPNF-DhSCphhFGppPsshp-D	....................................WLhGPsc.V.ps-.......................ssGhpppoGVhlcKCRY.LEpSsCsGhClNhCKlPTQ.sFFpcchGlPLpMpPNFEDhSCphhFG.tPPshppD..........	0	29	63	75
+13068	PF13226	DUF4034		Domain of unknown function (DUF4034)	Aldam G, Mistry J	gba	Pfam-B_2075 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 280 amino acids in length. There is a conserved PRW sequence motif.	21.30	21.30	21.40	21.30	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.87	0.70	-5.31	8	236	2010-08-19 12:03:56	2010-08-19 13:03:56	1	9	217	0	29	143	1	257.00	50	39.77	CHANGED	+ppph.clcphLp-pca-ELDchh-pthst.apu+puEpc...Yshshss.s..hhDhsollus...t.ptLAhL+AWppApPcShHAalspupYWp+pAhchRohuWApcVTcstWlsAttss-hslhAtLpAlsLcPR.hhAuhhhhssoshFGpPsWLusllpGpcstspslhts..thctph.pEspAhhuppGLpshsph...st.hPssLPsts-.cchpcsh.YWLpssLuIaPptFhshp-Yl.ahhPRW.GGSac-IccFlsSslCcpLSptE+spLchhlhWD	.........................................................RcWpIsDIsuLLREcRY-ELDEpYsQAL..TcSFTS.R-AE+R......YFhAWspMc...FYDMcTLV-A....GP...pGLALI.KsWQ....+ARP+STHAWL...AEAQYWsHRAWLYR.SYGWA+-TT+AMW..lCAAACNEpMVlAsLpAIDp-PRQWMAAuLhp..TsSpsFGpPsWLsthLsGscssu.PLht-Lt-YaccoPQElsALMAaSGL.uascAlsPslshPulLPcpsD.D..uGpK...YWLtVsLsIFPTsFYlhsEYIPF+MPRW.tG.SH-EIp-hL-SssC-HLSstE+-+LclLIWWD.........................................................................................	0	3	14	21
+13069	PF13227	DUF4035		Protein of unknown function (DUF4035)	Aldam G, Mistry J	gba	Pfam-B_2076 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 67 and 93 amino acids in length.	22.10	22.10	23.20	22.80	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.69	0.72	-4.59	18	233	2010-08-19 12:04:48	2010-08-19 13:04:48	1	2	184	0	14	135	5	52.90	61	63.23	CHANGED	htFDRpsPlGDhRsDh+sAQIup..AshsuQGs+..sslsDhM.tWspc.....-cctpDDu	..hEFDRlSPLGDERGDIRNAQIV+..AVFGAQGhs..VuLcDAMLsWGED.....EDcsEsDP.............................	0	0	5	11
+13070	PF13228	DUF4037		Domain of unknown function (DUF4037)	Aldam G, Mistry J	gba	Pfam-B_2110 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 100 amino acids in length. There is a single completely conserved residue P that may be functionally important.	22.10	22.10	22.70	22.10	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.11	0.72	-3.78	37	317	2010-08-19 12:59:41	2010-08-19 13:59:41	1	17	297	0	68	282	5	100.10	31	26.79	CHANGED	WLplPpppLups.TsGpVFtDsh.GphophRppL..paYP-DlhhthlAsphhphuQtGQaNhsRshpRsDthuutlshscFlcsshpLlaLLN+....pYhPYa...KWh	.......................................pphlush.psGtlhaDt..Gchspl+ccl..tsYP--LtcphIucpLhhh...sp..........a....Nht....+sL+RpDhluhhtsls-hhcshhsllFhLN+....hatPhh...KW..............	0	36	54	60
+13071	PF13229	Beta_helix		Right handed beta helix region	Bateman A	agb	Jackhmmer:O26996	Family	This region contains a parallel beta helix region that shares some similarity with Pectate lyases.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.18	0.71	-12.28	0.71	-4.48	178	5365	2012-10-02 14:50:22	2010-08-19 14:58:07	1	525	1536	7	2617	9515	1881	170.30	13	29.99	CHANGED	sGl....hlpssss.................hp.....lpssplpss......................tssGlhltssss....................hhlp.s......splps.........t..ul.h.t........................spsslpsstl......psss.........................uhhh...sssshlpssplpss........ts..............Gl...h..s................sss....spl....psNplpsss.........................tsGlhltsss....................sh..psNplp............sst........................tsGl.hhssss...............splpsNph	................................................................................................................................................................t...................................lt..t..p.h..t......................................tt..tG.lh..ht..ssst..................................................hhlp..s.........................splts.............................t.tu.l..h.ht.ts.................................................................sss.tlpss.pl......................psst..............................................tGl..hh....t.....s......s....s.....s...s......h..l.p.s......N..plt...ss.....................sss......................................................................Gl..hlt.s..............................sss.....................stl............ps.N.p.lp.s..st.....................................................................tsG...l...h...ltsss..................................ph..h.ps.N.h.lh...................s.st...............................................................G.h.......................................h......................................................................................................................................................................................................................................	0	1057	1738	2217
+13072	PF13230	GATase_4	GATase_II;	Glutamine amidotransferases class-II	Mistry J	jm14	Jackhmmer:Q7LYB4	Family	This family captures members that are not found in Pfam:PF00310.	20.70	20.70	20.70	20.70	20.60	20.60	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.65	0.70	-5.71	97	1953	2012-10-03 21:14:07	2010-08-19 15:05:10	1	8	1663	4	535	6397	3754	248.90	35	89.16	CHANGED	MCQLLGMNCAsPTDlTFSFoGFusRGGlT-cHuDGWGIAFFE..........DKACRLFlDpQuuusSPlAEhVKcYP.IKS+NsIAHIRKATQG+lhLENsHPFhREL.WGRHWIFAHNGDL.ps..asPpL....uGsYp..PVGsTDSEpAFChLhptLRctF.s.ts.pPsLsELFc.tlu-Lo+cIsc+GlFNFLhSNGQALFAHCS....T+......LaYlVR+a..PF.usAHLl.DtDlslDFuch..TTPEDRVAVIATpPLT.....csEsWTshpPGELlhFpsG...clstp.hplsss-tlhcchpss	.............................................................................MCpLhu.h.s...s..s...s...P.s...c..l..s..F..S...h...p..u...h.h.......p......R.u...G.....t......T.s...s....H..tDGa...G.I.u...FY-..............................s+.u.s.R..h..F..+....D..s...p...P....u...a......s.S.s..l....A.....c...h...l........p......p.....a.....s......I.......K......S.......p....s....V.......l..A..H.IRp...A..s.p..G.....p...V...s..l.p.N.o.HP.F........s.....R.....Eh...hG......c........p.W.s.a..AHNGpL...ss......a...c...slp................ssha.p........s......l.......G.....p.......T......D..S..Et.....A...F...C..h.l...L..p.....p..L....pp..........c..........h.....s.....t.........s....................ss...........h..s...........t........l.......hc.......hlt...........p.......l.....s............p..........p........l............p...........p.................t.................G.........s.........F.....N.h..l.L..S..D....G.c.h..lhA..as.s..............sp...............................Laals...R.c.s.........P...F...s...u......p.L.....h....D..p..D....h..p....l...c....h....t......p................sss..p..Dh..VsllATpPLT.................t.s.E.s..Wpth.sGphhhhp..Gp...................thh....................................................................................................................................................	0	134	273	423
+13073	PF13231	PMT_2		Dolichyl-phosphate-mannose-protein mannosyltransferase	Mistry J	jm14	Jackhmmer:O26471	Family	This family contains members that are not captured by Pfam:PF02366.	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.14	0.71	-4.33	106	4872	2012-10-03 03:08:05	2010-08-19 17:21:47	1	112	2057	0	1921	6160	2870	159.90	15	29.25	CHANGED	c+P.....PhhsW..lh....tlhstlh..G.s.sthulhlssslhsslshhhlatls+ph.hs.ppsulluslhhss.sshhsssuh...ths..Dshhlhhhhhshahhhpshp..csp.h..phh...lhsulhhGluhhoKattshllhs.hll..aLlhs........th.hhpp..thsal.sshlslllh.s.......lhW	.........................................................shhhh..hh................th..h.h...t...l.....h.............G.............s..............h...............s........h.....+......l....h...s....h...l...h....s.h.h....s....s....h....h.l......ah....l............s.............c......c...........h.......h...........s.....p.............p..............s............u.........h.........h.............u.......u....l.l....h....sh....h.s..h.....h.....h.h.........hut.......hsp.....-...sh...h.........h..h...h..h...h.....h...u....h.....h....h.............h.....h...........p.....h......h..p....................pt.......p....h...........t.......h....h..............hh...h..u...l..h..h......u....l..u..h..h...s...+....h....h....s...h...h...h..l...h...s...hhl........hl.lhp.....................pp...hhtp........hhhh...h.......s.h.hh.h..h.h.hh.......hh............................................................................	0	764	1422	1713
+13074	PF13232	Complex1_LYR_1	LYR-motif-like;	Complex1_LYR-like	Wood V, Coggill P	pcc	Manual	Domain	This is a family of proteins carrying the LYR motif of family Complex1_LYR, Pfam:PF05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.	20.80	18.60	20.80	18.80	20.70	18.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.07	0.72	-3.76	236	283	2012-10-01 20:54:40	2010-08-19 18:36:27	1	8	162	0	201	1849	13	65.40	24	34.50	CHANGED	pplLpLYRpl....LRpu.pp......hsshshp........................h...ppp...lRspF+.........................cs+s......hpD......................p.......pIpph.lp.pupc......................pL...phlp	.................................................tshpLYRpL..................LRpu..pp........................hs.s..hshR...................................pas...pc+........l+..ctF+..............................................cppp..........hpc.................................p.........clpph..hp..cuhp......................pLphh.................................................................................................................................................	1	61	104	165
+13075	PF13233	Complex1_LYR_2		Complex1_LYR-like	Coggill P	pcc	manual	Family	This is a family of proteins carrying the LYR motif of family Complex1_LYR, Pfam:PF05347, likely to be involved in Fe-S cluster biogenesis in mitochondria.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.91	0.72	-3.55	66	376	2012-10-01 20:54:40	2010-08-19 18:48:37	1	4	227	0	259	553	1	103.20	18	73.89	CHANGED	lhplYR..................plL.+pL.p....h................................................s.hcppl...........ppp...hpp.ppphs....................................................................httthpchpphhpalpsp+...tahph...hppY........p.Ght.hsp-cp..l...................chsuphVshp	.....................................................hplYR....................plL..+th.t........h......................................................................shhcphl.......................+pp...Fpp.pptss.................................................................ttthptthpchpp..hhphlpppp.....ph.ph....htph..................s....hs...pp.....................t............................................................................................................................	0	63	125	203
+13076	PF13234	rRNA_proc-arch		rRNA-processing arch domain	Wood V, Coggill P	pcc	Pfam-B_8473 (release 24)	Domain	Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homologue of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity [1].	21.30	19.20	21.30	19.20	21.20	19.10	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.62	0.70	-5.23	86	683	2010-08-20 10:00:23	2010-08-20 11:00:23	1	18	387	9	414	671	13	215.90	22	22.40	CHANGED	EaMLc+.SFaQFQsst.........................ulPtLEcclpclcpchsshpl......s-.........Esslp-YYcl+ppLpphpc-hRpll.......s+PpasLsFLQ.sGRLl+lpt...........ssp-aGWGl.....Vlsap.++p.st..pt....................................hsspppYlVDVLlps..s..cssstttps.................stshcPspts.-..cuch....pVVPlsL.sslpuISslRlhlP..cD.L+st-s..+pslh+sl.........pElp+R..F.P-G...lPlLDPlccMpIcDssFp+ll+KI-sLEs+LhssPLpsu..scLp..clYppapcKhclppcl+plKcclppu	......................................................E.Mlc+SFhQFQspp................................................................................slsthpc..plp.p.h.pp.phstlth...............c............................................pts...ltpY...aplppplp.p.hp.p.....p..h.p.phl.......hp.st.....hs....l..h.Lp...sG....Rlltlpt...............................................tt.p..c.hs.hGl.....llpht.ppt....................................................................................hhh.shh.........................................................................................hh.h.h....lttlsthhh...h...........p..h.....tt.............ht.....t..hhttl.........................tcl.ph........h..sts....shlcPhps..htl....p.s.thhp.............hh.php.hpphh.t.t.h.hp........s....ph..............t.h..htt+.tht.phpthc.........................................................................................................................................................................	0	147	240	346
+13078	PF13236	CLU		Clustered mitochondria	Fey P, Coggill P	pcc	[1]	Domain	The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in proteins from fungi, protozoa, plants to humans. It is required for correct functioning of the mitochondria and mitochondrial transport [1,2] although the exact function of the domain is unknown [4]. In Dictyostelium the full-length protein is required for a very late step in fission of the outer mitochondrial membrane [2] suggesting that mitochondria are transported along microtubules, as in mammalian cells, rather than along actin filaments, as in budding yeast [1]. Disruption of the protein-impaired cytokinesis and caused mitochondria to cluster at the cell centre [1]. It is likely that CLU functions in a novel pathway that positions mitochondria within the cell based on their physiological state. Disruption of the CLU pathway may enhance oxidative damage, alter gene expression, cause mitochondria to cluster at microtubule plus ends, and lead eventually to mitochondrial failure [3].	21.40	21.40	21.60	21.50	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.51	0.70	-4.92	42	412	2010-08-23 12:34:58	2010-08-23 13:34:58	1	64	248	0	310	412	5	207.90	35	16.22	CHANGED	DWN-EaQuh+ElPppolp-RlhR-RhltKlhp-FspsAsc..sAhsllpGplhPlNPp-spp........sphalhNNIFaShu.s-shspapphGG........DcA..AptAuspDLpulphlsph.....D.lsslppLsTsllDYtGpRllAQohlPGlhp....................p...slhYGus-.....................supplhscppFtphl.cphuchh+lKpHpV...h.....t.....hplhsSh-sKGlhGsDuR...pYlLDLhRshPhDlsah	.......................DWNEEhQss....+E....lP.pp.....slp..-R............lhR.-..R.......h.l.K..lhsDFssAAs+..GAhtllc.sp......lhs.lNPp-..pp......................hphalaNN.....IFFShu..hDs.h..spapphGG......................................Dp.A.....AhsAsspD.LpGl+shs.p.h........D.lpG....Las.sosllDYtGhRl.sAQ................SllP..GIhpt.........................................................ptpp.slhYGu.h..-.....................tsc...slh.s.p.......c.a.h.phh.pchuc.L+lptHtVh.................................spps..thcLhuos-sKGllG.s.DuR...pYlLDLhRhhP.Dhta......................................................................	0	124	189	271
+13079	PF13237	Fer4_10		4Fe-4S dicluster domain	Coggill P	pcc	Jackhammer:O26799	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	25.50	24.60	25.50	24.60	25.40	24.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.32	0.72	-4.16	189	7356	2012-10-03 08:56:43	2010-08-23 16:55:13	1	391	3234	1	2292	29622	8087	55.40	30	19.67	CHANGED	thhhs.pt.C.....h.tCt.....tChp.....s.C......P...................................h.httthttthth.ss.p.......................Cht.........................C......s.......tChps.CP	......................hh...hs.cp..C........l...sCs.......hChp..s..C............Ps............................................................................................tshp.t.t.p.p.h.h....pl....ss...s.p.........................................................C.h.p................................................C.....................G...............pChps..CP...............................................................	0	833	1631	2006
+13080	PF13238	AAA_18		AAA domain	Bateman A	agb	Jackhmmer:O27656	Domain	\N	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.82	0.71	-3.83	124	2477	2012-10-05 12:31:09	2010-08-24 11:57:14	1	35	1523	30	881	16173	6513	139.40	17	66.84	CHANGED	IhlsGssGsGKoTluctL.....tct......h.......................thhltchhhptshhhthsph..............tpttthshptht.hhpthtpt.........................tp.h...ll-shhsthh..tphh.hh...........................lhLpss..chhhcRlpp..Rshpt.p.............cptpschhp	..................................IhltGssGsGKo....Tls...ppL...............pcph.............................................................................thhh.h..p.........h...h..p..t...s...h.h..t...t.h.ppt.....................................................t.p.t......t.h..s.t.s...t...h..........h.h.p.thtp...t.......................................................................................................tt.t..t...l..........l....l..-....s....h..h...s...h..h.........t.p.h.h.hh.........................................................................lhLps..s...c..hh.h...cR.hps.....Rs.tp.p.t.p.......................t..................................................................................................................................................................................................	0	254	472	688
+13081	PF13239	2TM		2TM domain	Bateman A, Galperin M	agb	Jackhmmer:O27758	Family	This short region contains two transmembrane alpha helices that are found associated with a wide range of other domains.  This domain may be involved in cell lysis or peptidoglycan turnover.	24.80	22.90	24.80	22.90	24.50	22.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.96	0.72	-3.92	128	506	2010-08-24 13:02:44	2010-08-24 14:02:44	1	11	339	0	207	516	126	80.20	23	53.61	CHANGED	phppApc+l...cch+tFat.HLhsYllVssh..LhhlNh.hs.s.sh.................Ws...........l..a....sh...lhWGlGLhhH..uh.p...s.a......hhhup..pWcc+clp.chhp+	.......................pApc+l...pph...psFhh.Hlhsalllssh....Lhhlsh....hs...sssh.h........................Wh.............l.....a......sh.hsWGluLlhH.ulp...s..a.........hhst....pWppp.php.p.h.........................	0	49	140	187
+13082	PF13240	zinc_ribbon_2		zinc-ribbon domain	Coggill P	pcc	Jackhammer:O26621	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. Pfam:PF12773.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.03	0.72	-7.62	0.72	-4.35	442	1062	2012-10-03 10:42:43	2010-08-24 14:40:20	1	99	704	0	242	1992	209	23.00	39	6.97	CHANGED	hCspCGp.pl.s.c.s.spF......CspC..Gsp...l	........hCscCGp.pl.p.-.s.spF.........CspC..Gpt..........	0	98	197	231
+13083	PF13241	NAD_binding_7	Hydrolase_like;	Putative NAD(P)-binding	Coggill P	pcc	Jackhammer:O27094	Domain	This domain is found in fungi, plants, archaea and bacteria.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.27	0.72	-3.77	422	3188	2012-10-10 17:06:42	2010-08-24 15:53:40	1	33	2756	11	874	5098	3558	109.30	30	31.68	CHANGED	lhl.clps..+cllllGGGpVAt..c+lpsLlp.ts..A.c.l..sV........l.u...Pp.............htc.......................................ph.lp..............h........t........p.........+p.................................................a...........c.sD..................................l.p.....s..........sh..........lVl...uAos-..splNcp..ltp....ts..+.....ph..LsN.ssD........ss...ppss...........hhhPu	.................................lhhpLps+plLl.VGG..G..c.V..A...t....RKsphL..lc..sG...A.c......l..pV..........l.u..sp..............hp...................................................sh.lp...............h...........h........p.........c.t....................................................................a.........c.sp.....................................................L.c.s...............sh........Lll...A.AT...s...-....s..t.....l.....N.p.p....V.tp........sA.....ct......cpl.....h..sN.llD.....ss...ptssFhhPu...................................................................................................................................	0	272	556	743
+13084	PF13242	Hydrolase_like		HAD-hyrolase-like	Coggill P	pcc	Jackhammer:	Domain	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.81	0.72	-4.27	437	8522	2012-10-03 04:19:28	2010-08-24 17:11:02	1	48	4225	45	2343	23735	6396	74.00	26	28.24	CHANGED	s.GKP...s.shhhpt......Ahtth..............................shp..............................pp..........shh.lGDp..sDlhuuppsG..h.ps...lLVho.Gh...pst............pthtt.........h..pssh.l..hss.l...s-h	......................................................................................h.htKP..p..sh.h..hpp........Ahpph.................................................s.h.c................................................hpp............shh.V.GDphhoDl.t.u.ut......p......s.......G.............h....p.o.........l.L....V.h..o....Gh.....tp.......................tth........................ssh..h...h.sl....................................................	0	726	1394	1948
+13085	PF13243	Prenyltrans_1		Prenyltransferase-like	Coggill P	pcc	Jackhammer:O27751	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.50	0.72	-4.04	26	810	2012-10-03 02:33:51	2010-08-25 13:25:01	1	65	544	6	312	4104	349	105.50	17	18.46	CHANGED	lpshlphllspQpp-GuW....s..hs......hs......s........s.hssssthh.tshttt.....t.......ss...sstpul.c+us-alhc..pQps..-Guat...tp...stp...............sh....sp.ssh.hs.sh.hht.thht.........scpp.lc...+ulcalhpp....p.sc	..........................................................................h...hhth.lh..ptQ.....p......-....G.u..W.............h...hp..............hs...............s......................................s...h..s..o...s..h...sh....u.Lt.th.............s.....................ss......ssp.s..t.l..p.....+..u..s.p....aLhs...........p.Q..p.t...........D.........G..u...a.u.........ts.........stt.................................................................h....th....h.....h.....h...........................................................tt.........................................................................................................................	0	121	211	269
+13086	PF13244	DUF4040		Domain of unknown function (DUF4040)	Coggill P	pcc	Jackhmmer:O27316	Family	\N	30.00	30.00	30.30	30.30	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.25	0.72	-3.99	434	1807	2010-08-25 15:48:25	2010-08-25 16:48:25	1	9	1353	0	544	1494	224	71.00	34	10.23	CHANGED	hhlllluulss.lh..t.+s+lsAllhhGlhGhslulhFhhhuAPDlALTQhsVEs.loslLhllslppl..............sphtp	...........h.llhlssu.l..h..h.lh..t..+pRLsullhhGshGhslulhFlhhpAPDLALTQh.lVEs.loslLhlL..shp+LPp...................	0	159	338	455
+13087	PF13245	AAA_19		Part of AAA domain	Coggill P	pcc	Jackhammer:O26587	Domain	\N	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.74	0.72	-4.22	209	2781	2012-10-05 12:31:09	2010-08-25 16:49:56	1	100	1622	0	906	20876	4566	80.60	23	8.66	CHANGED	cAlt.uht......ssl...hllsGGPGTGKT.sslptlstlh........................t...sttlLll..uPoscAsc.pl.tpth...........................h..upolcplh	.......................................t.....t.t......psh.......hll.pGsP.GTGKT.s....s.h....l.p..t.lAhLl.............................................................................tt.......s.p..p..l...Ll..l.....u...s...p.s.h.hc...hl.pphL.........................................t................t............................................................................	0	336	668	820
+13088	PF13246	Hydrolase_like2		Putative hydrolase of sodium-potassium ATPase alpha subunit	Coggill P	pcc	Jackhammer:O26582	Family	This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.28	0.72	-4.03	225	1746	2012-10-03 04:19:28	2010-08-25 17:23:33	1	71	1074	0	530	10781	261	97.10	34	14.14	CHANGED	sLCNpup.....h..p...tt..............................................hhG-.soEsALlph....scph..hts..............................................hpt.....h+...pphp+ltp..lPFsSspKhh..ssl.......................t..............................................sst.......hh.hhKGAPEplLc+...Co.pl	.............................................................................................................................................hLCNcup..h..sptpts.......c..............................................hsG-.soE.uA..L.lcs.....s.c.hh.....hts..........................................................................................................................shs..........h+.......pc..........c...+...l...sp.......lP.FsS...s.p.Kh.....ssl...........................t..cs..............................................ssss....t..hllhhK...GAP.EpI..L-R..Coph............................	0	204	318	445
+13089	PF13247	Fer4_11		4Fe-4S dicluster domain	Coggill P	pcc	Jackhmmer:O26500	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.29	0.72	-11.02	0.72	-4.11	103	12420	2012-10-03 08:56:43	2010-08-25 17:37:53	1	136	2648	60	1943	6770	905	93.70	38	31.84	CHANGED	shhhYLPRlCcHCLNPsCluuCPuu....AlYKRpE...........DGlV.LlDpcpCR....GaRhClouCPY+psaaNapoG..+uEKCs.hCaPRlE....sG.s....ssCscoCsu+hRYhGsh	..........................................h...hhshtC.pH...C..p......c..s...sClssCPsu................Ah.h+cp....................s.GlV..h.ls..p-p.Cl.....GCc.hChhACPas........s.....h...............p.........h................s...............p....ss.....................ps.p.K.Cs..hC......h......t......R.ht...................G............................PsClc.sCs.s...p...AlhhG..h............................................	0	603	1190	1602
+13090	PF13248	zf-ribbon_3		zinc-ribbon domain	Coggill P	pcc	Jackhmmer:O26570	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR. Pfam:PF12773.	23.80	23.80	23.80	23.80	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.63	0.72	-8.29	0.72	-4.63	487	1966	2012-10-03 10:42:43	2010-08-26 11:58:27	1	152	1261	0	583	3186	312	25.60	36	8.81	CHANGED	t.hhCspCGp.p.h...sss.......spFCspCGspl	.........hhCPpCGp.p.h......pss...................spFCspCGppl.....	0	221	418	509
+13091	PF13249	Prenyltrans_2		Prenyltransferase-like	Coggill P	pcc	Jackhmmer:O26856	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-11.04	0.71	-3.67	105	3084	2012-10-03 02:33:51	2010-08-26 14:46:15	1	123	1058	183	1552	4407	373	121.60	19	29.92	CHANGED	lchlhs..t.Qp..sDG...u..as..................h.................tp................tsssshTu.hAlh...uL....t.shspps.......s...............hcch................................hpal.p.p.ppp...sGu..ast..........sst............s..tss....hps.shh..sl.t...sh.......phh..spp......................phhpp....s.....lp.........alhs.hQ....s.......s....s.G.Gaph	...........................................................................thlht.h.Qp....t.s.....G....u...au..............................................s..................tp.........................spsssTs...ts..lt....sL.......s..hhuppp......s....................tpph............................................................hpaL..hs..hQ..........p....s.D....Gu..ahs..................p...........................................t..s.s..t...h.h.s...oh....h......ul..s..ul............thh.s.h.tt........................hpc........u.........hp..........al.hs..hQ......p............c.G.Gat.t..............................................................................................	0	523	955	1309
+13092	PF13250	DUF4041		Domain of unknown function (DUF4041)	Aldam G, Mistry J	gba	Pfam-B_2162 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and viruses, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF10544.	21.00	21.00	21.30	22.50	20.40	20.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.39	0.72	-4.41	57	210	2010-08-26 13:56:30	2010-08-26 14:56:30	1	3	206	0	39	173	8	55.90	33	12.28	CHANGED	KhhlRuFNuEsDsslsKVphsNlsphccRIp+uFcplNKlspt..slpIstpYLpLK	....KhhlRuFNuEs-shlsKVshpNlpshpp+ItKua-tlNKlhcss.slcIsppaLclK......	0	15	26	32
+13093	PF13251	DUF4042		Domain of unknown function (DUF4042)	Aldam G, Mistry J	gba	Pfam-B_2172 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 180 amino acids in length.	21.60	21.60	21.60	22.20	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.07	0.71	-4.82	19	156	2010-08-26 14:01:37	2010-08-26 15:01:37	1	11	113	0	95	151	1	167.50	31	16.22	CHANGED	KVRluALthlpsls+sh-++shaGYWpslhP-s.......ttsttpsoLhshlLpDPss+sRssAlpsluthLpGS+.aLsQAsptc..ssptuFTsFSsoLAshlhplHcsLhhhLppEsssshLsQllKCLulLlpsTPYpRLphGllschlppl+.hlcc...pDsslpVuuLhshshLlu.s.t.hsEh	.......................+lR.uAlhsh..shhcp.c.p+.sl..auYWsshlP-s.............................hs.pstss...........oLhT.hhLp.DP.ssKsRssAhpsLuslL-G..u..+paL.......sh........Ap-sp....................spptuFTsh..Ssplus.lhpLHcsLlhuL............tEss...st..........sLs.pllKsLu.....sLlpssPYpRL.....p.............sLlsplh...ppl+shlpc.........pDsslpsssl.hhthlhus...h...................................................	0	38	54	75
+13094	PF13252	DUF4043		Protein of unknown function (DUF4043)	Aldam G, Mistry J	gba	Pfam-B_2174 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 369 and 424 amino acids in length. There is a single completely conserved residue G that may be functionally important.	21.10	21.10	23.50	22.80	19.30	18.90	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.73	0.70	-5.46	33	188	2010-08-26 14:03:29	2010-08-26 15:03:29	1	2	154	0	29	134	71	315.30	39	84.63	CHANGED	supsusI.chs-LpK.ssGDp.lsasLhspLsucs.shGspplEGptEsLphhspplpIsphR+sVcss..GpMspQRohaslRctA+stLssahschhDphhhlpLuGsp.s...s......s.ttpsphsthtsNslpAPossRhhhuusssstt.............slsu..sDhholchl-phsthuct......s.thhpsh..hs.sucsh..YVhhlsPtQhssL+sssshtp...W.phtpsshsuspu.psPlFp.GshGhasslll+cht.hshphssuss...............................usssslsRAlLLGuQAlshAaGp...........tuuttatasE.......EphDasschtlusstlhGhKKsRFss..st.....pDaGllslDT	........................................t.sssuPlsRhsDLsK.puGDc.lsFslhppLotcP.shGDpclEG..+GEsLpass.sL+INQuRHhVcuG....G+MopQRohasLtppARshLssahschtDpshllHLAGAR.shhss..phhlshstcscapchhhNsVhsPTpcR+hhuussoshp.............plcu..sDlFolsllDshshhl-phshs....slc.h.sst.....hh..sp-sh....YVlhloPtQhschhososs+p...W.phhstssstu+u.ppPLFc.GpsuMapslll+KhsthPIRFhpusp..hstsp.st........................stphsussslcRAhLLGAQAls.AaGp..................cuGtpFphsE.......cphDhsN+sElulshIpGlKKhRFspcsGph......pDaGVIslDT...........................	0	5	12	21
+13095	PF13253	DUF4044		Protein of unknown function (DUF4044)	Aldam G, Mistry J	gba	Pfam-B_2177 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 56 amino acids in length. There is a single completely conserved residue M that may be functionally important.	20.30	20.30	21.00	21.00	19.60	19.20	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.34	0.72	-7.48	0.72	-4.80	32	476	2010-08-26 14:04:45	2010-08-26 15:04:45	1	1	473	0	39	139	0	34.90	49	77.51	CHANGED	tp++KKosFpKlThlhVhlMlllTluullhuAluu	.....NGpRKKThFEKlTlhlVllMLlsolhGlhAoAluu....	1	5	18	26
+13096	PF13254	DUF4045		Domain of unknown function (DUF4045)	Aldam G, Mistry J	gba	Pfam-B_2180 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.	21.50	21.50	22.00	21.50	20.90	19.60	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.75	0.70	-5.19	12	108	2010-08-26 14:45:42	2010-08-26 15:45:42	1	8	72	0	88	107	0	241.30	29	23.98	CHANGED	RSoSPTKGLGGFVQSAMMKRSDSVSKRWSAQ.........PsshsRs.sShhSsRsShtustt.ss..s...........sp...........................sRPuSSHSEATlV+psp.cs-h.so.ss.........s-shs+ssLs.+stSpSsssss.....sushs.shssosS+TMD.+RWSP..TKuoWLESALN+P-SP+pKtQ..spp..spWhK-.....RQuRuSVDLGRssShK-......htp.s.Gscspssohouhssh.spp-spsscttps.............s.ts...pt...css.ps...csp.ph.pssEtssppss....................tstthtsPs.hsssststssss.....lsu.....pDsl.s+sKPpoP.l.hDFRANLR+RElsp-posp-E.PEFKNVFGKLRKsEopNYVAPD.LK-NIL+GKAALNuTGGPKKop+VDEhKESILK	...........................................................................K..s.................t...s.....................................................................t..................................................................................s.sso+s.p.+RWSP..oK.u.oWL-sALp+.s.-.Pp..................t............t.....................................................................................................................................................................................................................................s........saRusL+.R............t.....t.t...p..s..EhpslhGpL++scsppahsPD.hKtNIhpGKssLs.osGP..s.hhD-h+-ul............................................	0	16	41	71
+13097	PF13255	DUF4046		Protein of unknown function (DUF4046)	Aldam G, Mistry J	gba	Pfam-B_2182 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 64 and 331 amino acids in length.	20.90	20.90	20.90	20.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.31	0.70	-5.67	13	108	2010-08-26 14:47:10	2010-08-26 15:47:10	1	4	56	0	23	94	4	180.70	41	86.05	CHANGED	IE-IYQEILDGKRpRFPsNTWp-DpcNELARRVT+YLIEslLKW-c--I+psWNopLIlKY+LpGlLpp+YsNSPY+MlNDlYPscFKEWEFpMTPLNFWTKEKALEsLKWTIEEKEpLSspcLLclYupKWLccpKLuuPLphaWsGSPYsMIN-LYPsRFKEWEFpMTPNpFWTKEKALEALKWTIEEKEpLss-QLhplYsl+WLpppsLposCplaWssSPYuMIN-LYPspFKEWEFKhTPssFWTKEKALEALKWTIEEKEKLo-EQLLpVYoh+WllKp+LhTPLhRYWpGSPYA	.................................................pIYpplL-GKpp+FP.shW..tpc..s.p..c.h.t+R...s...hpYLlpphLchp.....pp...I....php..hlhpY+L.hhl....pt.s..thlp-haPp...............................................................................hapsSP...athlssLYP.t.+apc..h....................................................................................................................................................................................................................	0	3	21	23
+13098	PF13256	DUF4047		Domain of unknown function (DUF4047)	Aldam G, Mistry J	gba	Pfam-B_2183 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There are two conserved sequence motifs: TEA and FPKT.	22.00	22.00	30.30	30.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.75	0.71	-4.17	5	74	2010-08-26 14:53:30	2010-08-26 15:53:30	1	1	73	0	3	62	0	125.00	72	47.63	CHANGED	VVTYTEAAFVsETKVQuoISTAIVFPKTIDTLscpAcQHEclIL+sYEsMKpElcs-.SlElLEQplssW+pQREKVssEREALQ+IYTEIEsYYsQlpEsl+sccS-SsKcVLpYVNAGF...ppVK-	.hMTYTEAAFIHETKVt.A.TISTA.IFPKTVDpLhEQAcQHKclILHEYcpMKuKLpsp.SspEIEQAlslW+QGREKIsAEREuLQ+VYppIEpPYNQlQEELKs.NpoESsKQVhsYVNtGF+hVKE.......................	0	0	1	1
+13099	PF13257	DUF4048		Domain of unknown function (DUF4048)	Aldam G, Mistry J	gba	Pfam-B_2186 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is typically between 228 and 257 amino acids in length.	25.00	25.00	29.60	29.60	20.70	19.30	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-12.12	0.70	-4.74	14	71	2010-08-26 15:06:14	2010-08-26 16:06:14	1	2	69	0	56	72	0	205.90	30	36.84	CHANGED	HTRTLSLLSPsssss.........ss.sssssssssRsoRpPRSATLP.SV-Rosssps.t......uspso--.hspWRRohPP....PopEALMRTG+QMASDLREGLWTFLEDIRQATVGEEGINATcSRs.......ss...+pssspusSRu..............tsGpsupSsoupSupupssssup.......psop...Sss.-sSFWSEFGIDossQp............tsppspsossssp.......pppppsp.....pss.LDl...D.DNWDsWDTPQP.pKoHTPSSSpS	..................................................HhRsLSLLSs....s..................tps...t....Ptssp.P.Sh-ct....................p.hs.WptshP.....spt-tlhpsG.+QhApDh+pGLWTFlEDIRQATVG-EuI....N..u..s..p..sRs.tt..............tpssspuss+s......................ttsssstspoupu.sp.p.s...stt.............sppsp.......stt.p..sF.Wp-hGhss......................sptstss..st..............................t.pt..................-....................-.ps..Wp.WD.oP...............................................................................	0	8	24	43
+13100	PF13258	DUF4049		Domain of unknown function (DUF4049)	Aldam G, Mistry J	gba	Pfam-B_2191 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 310 and 324 amino acids in length.	25.00	25.00	40.40	40.00	20.60	19.00	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.06	0.70	-5.46	3	501	2010-08-26 15:31:45	2010-08-26 16:31:45	1	1	233	0	2	271	0	263.30	60	58.68	CHANGED	pNsNTAYFGDTDGRVGAVLYALLVSGHIGIRuEGWSLLCQLLKHEDMASsAYc+K........NlKsLaoLLNTRDMILNELHQHVFLKcDAITPCIFLGDHTGDRFSTIFGDKYILTLLNSMRNMEGNKDSRINKNVVVLAGNHEINFNGNYoARLANHKLSuGDTYDLIKTLDVCNYDSEpKVLTSHHGIIRDEE+KCYCLGALQVPFNQMKNPlDPEELANIFNKKHKpHMDD+LFHLIRSNol+STPVYsNYFsNTTDFRPKhEcIFtCGQTLKt......I+QKYGHaGsGVDcsQphDNslMGLNShKpA+scRschhhsSGLSCF	.......psspssYFGDTDGpVGAVLYALhsoGHlGIhtcG.shLspLLphED.s.sshh+c........NsphlhslLNpRDhlLppLp.alhlpcDAlTPChFLGDpTGDRFSsIhGDpaIlsLLpphhs........INcNVhVLAGNHEhNhNGNYhtphsphK..stDTYshIKshsVC.YDsch+lhssHHGIhhD-ppKpYhlGslpVshspMpNshDP.ELAsIhNKKH+thhss+hF+h.Ru.ohts...aspYFssoTDaRPK.EslhtCuQhLt.......IpQhhuHpG.Gscpp.t.ssslhGLNuhctthstph......ShhsC.....................	0	2	2	2
+13101	PF13259	DUF4050		Protein of unknown function (DUF4050)	Aldam G, Mistry J	gba	Pfam-B_2193 (release 24.0)	Family	This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 173 amino acids in length. There are two conserved sequence motifs: IPL and FLVD.	22.80	22.80	23.60	25.10	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.79	0.71	-4.19	61	243	2010-08-26 16:15:28	2010-08-26 17:15:28	1	5	148	0	159	242	0	146.50	25	51.54	CHANGED	hssushch-sssshspp.........................................tcpptt...pp.hpp...p......hhNpGLtlWppRRptWsGscppp................................................................................................................................................................pspthRp.......s.hsas.shYcpLlspspshs..pPIsLu-hl.........chLVsGWcp-.Ghas	.......................................................................................................................................t.t...................................t......t.p.p.pp.p...tptspp..pt.......hhNpG........LhlWpppRptWsGsppp.p................................................................................................................................................................p..ppth+p.........s....hsas.sh..Y-pL.ls.........s..scs.hs..pPIsLu-Ml................chLVssWcp-Ghas.............	0	35	92	135
+13102	PF13260	DUF4051		Protein of unknown function (DUF4051)	Aldam G, Mistry J	gba	Pfam-B_2194 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	90.10	90.00	24.70	23.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.93	0.72	-4.63	5	389	2010-08-27 08:24:20	2010-08-27 09:24:20	1	1	389	0	3	31	2	54.00	83	94.76	CHANGED	MFIAWYWIVLIVLVVlGYFCHMKRYCKAFRQDRDALLEARNKLhRRssEEsStp	MFIAWYWIVLIsLVVVGYFLHLKRYCRAFRQDRDALLEARNKYLNSTREETAEK....	0	0	0	1
+13103	PF13261	DUF4052		Protein of unknown function (DUF4052)	Aldam G, Mistry J	gba	Pfam-B_2197 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 220 amino acids in length.	25.00	25.00	61.60	61.50	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.49	0.70	-4.90	7	72	2010-08-27 08:59:02	2010-08-27 09:59:02	1	1	71	0	2	52	0	212.20	66	97.78	CHANGED	LMKQLKLHINaHYKAILIFWhVALLIKGssoshDlKsI+luFLpDIhNNPSIAIhhFIVlSsFlIQ.DlFRLAVSFGVTRLQFFIGSlCYIlLQSAhFSFLQllhLQshhYpscshSLGupSlcQFFVQFLhYVTlAshFQssVIFppRFpWIGhulGuhFFlGLsSVhYutsGlKtLshpsotsLlsIP.FIhISIsLhllYhllSuIhIRKVSFE	LMKQLKLHIpapYKAILIFWhVALLIKGshsAscLpGlKluaL.-IhNNsSIAIhhFIVsSVFlIQ.DlF.hsVSFGVTRlQaFIGuICaIlLQSAlFShLQllhLQshhYph.plshGppulpQFhlQFlFYsTlAChFQssllFppRFpWlGLhhushhhhuhsSshYutlGIKtLlFhsstsLl-IPaFIslSIsLhhlYIlhSulFIRKVSFE......	0	0	1	1
+13104	PF13262	DUF4054		Protein of unknown function (DUF4054)	Aldam G, Mistry J	gba	Pfam-B_2204 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 120 and 152 amino acids in length.	22.40	22.40	23.20	22.80	21.40	19.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.39	0.72	-3.79	59	275	2010-08-27 10:40:30	2010-08-27 11:40:30	1	1	248	0	36	227	20	106.50	27	80.09	CHANGED	F+ttaPpFss...hP-stlphhls.A.phhlssp.........phuc.hhppuhtLhsAHhhsLsttstt........sus.ssu..hhoStssGplSlS.hssssssss.shh..hspTsYGppahpLhp	............................................F+ttaPpFss...............hscsplphhls.A.s.hlsps..........thsc.hhthhhtLhsAHhhsLtstsst......................................ssutssu...shoS..cosuplSlS.assss....s.....tss.ts..a.....aspT.YGtpahpLh...........................	0	6	22	28
+13105	PF13263	PHP_C		PHP-associated	Coggill P	pcc	Jackhmmer:O27523	Domain	This is a subunit, probably the alpha, of bacterial and eukaryotic DNA polymerase III, associated with the PHP domain, Pfam:PF02811.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.61	0.72	-4.46	143	736	2012-10-03 00:45:34	2010-08-27 12:03:46	1	15	540	9	305	732	62	49.30	25	16.25	CHANGED	spsNccAtphAcchslPhhuGSDAH.hspplGpuhThh.......stshp.....s...c-llpul+cGps	..................s.phApphs.lPhlsuSDAH..thp..plG..psas.h........................s....tthhthlht......................................	0	98	213	275
+13106	PF13264	DUF4055		Domain of unknown function (DUF4055)	Aldam G, Mistry J	gba	Pfam-B_2501 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 140 amino acids in length.	25.00	25.00	27.90	27.70	23.70	22.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.59	0.71	-4.08	30	180	2010-08-27 11:19:37	2010-08-27 12:19:37	1	2	157	0	27	167	145	136.70	29	31.58	CHANGED	PLLsLAplNltHapsSADhcp.lahsupPphhlsGh..ssp..........tslpl.Gupush.LPp.sus.htalchousuls..+pshcchEspMhphGA+llppssss.cTuspupt-pssppSsLtshssslp-AlspuLcasApalG	....PLLsLAplNltHapspuDhpp.lahsupP.hhhpGl...spp........................pslsl.Gupssh.L....sp..s...us.ht.....alptsusult..+pshcchcspMhphGA+..l.lppssss..couspspt-pssppSsLtthssslp-AlspALphsAcah.............................	0	4	12	19
+13107	PF13265	DUF4056		Protein of unknown function (DUF4056)	Aldam G, Mistry J	gba	Pfam-B_2502 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 355 and 380 amino acids in length.	21.10	21.10	22.10	71.80	20.70	19.50	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.70	0.70	-5.40	27	134	2010-08-27 13:34:41	2010-08-27 14:34:41	1	1	128	0	22	109	0	263.80	52	72.18	CHANGED	hsshs.ls.sPpGLRPCCAFGYsL+sclhGlPVPFYplsNVl-s-sLGpH+YNDuhhus...susLlG..lusEpNGLlYTp+GGFIDlAHVRDTADhThYLFopIhs+LGppaplsLssELusRpIpa.ps...ssPhssp-RasLoAaLAApLAFpLAtWHEIAQWYGapSVsGFsEtlSAFSPEDLYSNhLGA+LAhslILpupshShptaspuhsphL.puLppLtAhscspT+ptFcplDGhWWsSp+RlP-KaLVL+RcYclupsRhPshsstp	..................s..ssP..GLRPCCAFGYsL+splhGlPVPFaplsNVl-lDsLGtH+YNsus.uh...ssuLlG....LScEpNGllYTcRGGFIDhA............HVRDTADhThYLFpplhspLGp.thplsLssELtsRpIpa..ps..o..sslsscERhpluA.lAAalAFpLApWHEIAQWaGhpSVsGFsEtsSAFSPEDLYSNhLGA+LAhsllLs............s.stspppaspshsphLcptLpcLtAps.pshTptphppLDGhWWsSpRRlP-KaLlL+RcYcLu.shLPs.ss.s-.......	0	2	7	16
+13108	PF13266	DUF4057		Protein of unknown function (DUF4057)	Aldam G, Mistry J	gba	Pfam-B_2503 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 279 and 322 amino acids in length.	21.00	21.00	33.20	23.10	18.90	18.80	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.16	0.70	-11.98	0.70	-4.95	13	114	2010-08-27 13:36:17	2010-08-27 14:36:17	1	7	22	0	65	120	0	222.50	44	87.59	CHANGED	RuTPVRKPH..TSTADLLoWs..EsPPssus.....usus.sutRsHQPSDGISKVVFGGQVT-EEAESLsK..RKPCSuaKhKEMTGSGIFussucs-uuEsuuuss.ss.KTslRhYQQussuI.SQISFupEESVSPKKPTSlPEVAKQRELSGTLcoEuDsKhpKQlSsAKsKELSGHDIFAPPPEIpPRsh.ss..Rthth+tshshucsss+shppushhsssAGu.Sph.hsp-sVlKTAKKI.asQKFsELTGNsIFKGDs...sPuSAEK.sLSsAKL+EMSGSsIFADGKu...poRDYlG.GVRKPPGGESSIA	....................................................slRtsH..tsTusLL.Ws.................................ss.ssh.sh.........pPu.tslp.hhh.Gu.lopcEspsLsK......+K.CSs.KhKEhTGSGIFsttupstss-su...sss....+Ts.+.aQth.ssl.SpISFut-tslSPKKPoolsEVAKQRELSGThpo.-s..-sKhp.+.QhSpAKsKELSG.psIFuPP.-..s+s......................t.t....t.........s..ss.....hs.p-sshKT.uKKI..spK..ht..-L.oGN.........sIFK.tD....ssuoA.E.K...LSpAKL+EhoGssIFADG.Ks....sRDhhG.GhRKPPGG-SSIA..............................	2	13	45	55
+13109	PF13267	DUF4058		Protein of unknown function (DUF4058)	Aldam G, Mistry J	gba	Pfam-B_2520 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 244 and 264 amino acids in length.	25.00	25.00	39.30	33.10	16.40	15.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.76	0.70	-5.25	21	75	2010-08-27 13:37:48	2010-08-27 14:37:48	1	3	27	0	25	78	0	216.80	37	96.42	CHANGED	MtsPFPGMsPYLEpPslWP-VHppLIssluDtLsPQLpP+YcssI-cRlYhtsspps...lllu..l..PDVsVhcpp..........ssssssuss.ssspPlsVslshs-.l+psaLElR-Vss.ppVVTsIElLSPsNKRsGcGRt.sYp+KRpclLsStTHLlEIDLLRuGp.....shPh.hsshstucYpILlSRuscRPpA-lYshsLp-PlPshslPLpssDs-shlDLpsllpplYc+AuY-htIDYp...ppPsPP.Lssc-ssWlcphL	......M.sPFPGMsPYLEpsthWs-VHptLIsths-hLtspltPpYhstlp.hlh.tt..pts.......hhht..lPDlsVhppp.................ssssssss.s.stP.hslth.h...s..h+pthlElRplts.tplVTsIElLSPsNK+sG.spt.tYppKRpplhtS..sHLlEIDLLRtGp.................h...ss...ssYhlllSRupcRPt...s-las..hsLppslPshslPLp..Ds-shlsLptllpplYccutYch.tIDYp...p..s.Ps.Ls.p-.tsWlpth.......................	0	7	23	25
+13110	PF13268	DUF4059		Protein of unknown function (DUF4059)	Aldam G, Mistry J	gba	Pfam-B_2521 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DKT sequence motif.	25.00	25.00	43.60	43.50	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.41	0.72	-3.79	11	344	2010-08-27 15:00:50	2010-08-27 16:00:50	1	1	341	0	20	91	0	69.40	64	96.52	CHANGED	MLlpIFuLYlpGLlLuslhllllullWlhaRAhp+hDKTu+ERQuaLYDhLMIuIhTIPILSFAhMuILLVl	..MLlplFSLYhcuLILToILVLIhLGIWIGLRAhSGVDKTA+sRQAHLYDMIMIGVLllPVLSFAVMSLlLVF.	0	1	3	11
+13111	PF13269	DUF4060		Protein of unknown function (DUF4060)	Aldam G, Mistry J	gba	Pfam-B_2524 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: VEVV and SYVAT.	20.10	20.10	22.70	25.00	20.00	19.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.38	0.72	-4.05	7	128	2010-08-27 15:01:51	2010-08-27 16:01:51	1	1	118	0	14	64	0	72.90	57	90.07	CHANGED	hI.RucpsPlthhAscsALstHhptYG-.GRQth.ssYolthcus+lsVEVVsR+pSYVATsMsGsR+LppLPG	.hI.+.uc.ps..thhsscsAlstHpcpaG-.uRQtasosYpVhhcss+VsVEVVsRppSYVATsMIGsRpLppLsu......	1	0	3	9
+13112	PF13270	DUF4061		Domain of unknown function (DUF4061)	Aldam G, Mistry J	gba	Pfam-B_2526 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 90 amino acids in length. There is a conserved AFG sequence motif.	21.90	21.90	21.90	22.90	21.80	20.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.92	0.72	-3.89	14	156	2010-08-27 15:03:06	2010-08-27 16:03:06	1	3	79	0	89	134	0	85.20	58	39.73	CHANGED	VsDV+cME+uLLsLLsDFHSGKLpAFGpsCohEQMp+lRE.QEpLA+LHF-Lsspt-chs-c...........ttpppspuppNMc+LlppLEpLS.SIpK	..........VoDVpEMEpGLLsLLNDFHSGKLQAF.G............p-C..S..hEQMEHVR-MQEKLARLHF-L.sphE-....sE-...............p++stuDpNl-pLLssLEpLs.SIpp................................	0	20	27	54
+13113	PF13271	DUF4062		Domain of unknown function (DUF4062)	Aldam G, Mistry J	gba	Pfam-B_2536 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.	21.90	21.90	21.90	22.10	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.65	0.72	-3.96	28	368	2010-08-27 15:04:52	2010-08-27 16:04:52	1	88	282	0	170	346	35	85.70	28	9.79	CHANGED	plFlSSTapDLp-ERpslhpsl.hchsahPhGMEh..F...sAu.DccphchhpchI.DcsDhYlLIlGsRYGShs....csu...hSaTctEY-aA	................................plFlSSTap..D.hptE......R...p........tlhc........s...l........hp..........h......s...........h.hs.h..th.Eh.....h.................ssp..sppp...hc.ls...h....cpl.cpsD......ha.....lh.llGsRYG.hs.......t.ps...................hSh.sp.Ea..A................................	0	73	110	140
+13114	PF13272	DUF4063		Protein of unknown function (DUF4063)	Aldam G, Mistry J	gba	Pfam-B_3026 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 95 and 123 amino acids in length. There is a conserved RRA sequence motif.	22.10	22.10	34.40	31.50	19.10	21.40	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.47	0.72	-4.24	16	129	2010-08-27 15:06:18	2010-08-27 16:06:18	1	1	114	0	24	92	1	88.90	52	81.40	CHANGED	sRLssallsullLLhslullSPQQ...LPVllYKLSLlsLAAlsGYWLDRsLFPYARPuuYL....p......ctssh.hupu-aPls...pGYphlFsAAhLRRAlIVu.ushLuVuLG	..........PRLouWLlsollLhulIu.hsSPtQ...lPVVlYKLoLloLuAVLGYWLDRSLFP.a.A.RPsuah....h...............................................................................	0	6	15	20
+13115	PF13273	DUF4064		Protein of unknown function (DUF4064)	Coggill P	pcc	Jackhmmer:O26620	Family	\N	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.74	0.72	-3.90	50	1109	2012-10-02 01:14:40	2010-08-27 16:08:03	1	4	408	0	62	435	1	101.60	24	57.04	CHANGED	KRTsEhlLulIGs...Ilu....ll...huhhhlh...l..u.h.h......u.s...........tp....h..........................................hhhshhullhsIl...uI......luull..lp+....cs..p...luGllhlluullslls	.....................RhsEhlLuh...Iuh...llt....ll...hslhshh...h.h.hl......us................sshtpphttphs..t..................sp.hhshhpsh.h.hslhlhh.l.l.shll....uh......luhl.t...hpt....pp.+..luGlLhlIuuIlsh..s................	0	17	32	58
+13116	PF13274	DUF4065		Protein of unknown function (DUF4065)	Bateman A	agb	Jackhmmer:B5ZAK8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and viruses. Proteins in this family are typically between 155 and 202 amino acids in length.	25.70	25.70	25.80	25.70	25.50	24.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.83	0.72	-3.35	264	905	2010-08-27 15:57:42	2010-08-27 16:57:42	1	8	726	0	195	777	25	106.70	22	56.07	CHANGED	LpKLlY.a.upsht....lth..s....p............s.......lh.s..-ph.pAapaGPV.......h.....p...lYpph+.........tht.....................................................lspppt..c....ll-...pl....hppau....ph...su.hpLpch.oH.....................t.ts.W.........pps	...................LpKLlYaupshtlth.hs...c...................s........Lh.s...pph.pAWpaGPVhsp..........lapth+.........tht......................................................................p.pplspppt.....c.........lls...pl....hppau.......ph..............ss.hpLtch.oH.tp.ts.W...h............................................................................................	0	85	142	174
+13117	PF13275	S4_2		S4 domain	Bateman A	agb	Jackhmmer:B5ZAQ9	Domain	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.95	0.72	-4.38	202	2674	2012-10-01 23:15:27	2010-08-27 17:10:54	1	5	2633	1	435	1579	178	65.30	38	73.24	CHANGED	lpl.ps.-aIpLsQlLKhssllsoGGpAKhhlt-s..tVtVNG-sEsRRG+KlhsGDhVph......s..spphplh	......................l.p.paIpLsphLKhtGlscSGGpAKhhls-s..pVhVNGp..lEoR..RG+KlhsG.DhVph...s.stphpl..............	1	129	267	362
+13118	PF13276	HTH_21		HTH-like domain	Bateman A	agb	Jackhmmer:B5ZBQ5	Domain	This domain contains a predicted helix-turn-helix suggesting a DNA-binding function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.02	0.72	-3.96	515	11498	2012-10-04 14:01:12	2010-08-27 17:18:47	1	58	2749	0	1982	9551	1161	59.50	26	23.43	CHANGED	p....h.c.p.t..h.h.pt.............Ipplap...pp...pt...........pY...GhR+l.pt.tL.c.....c................p....h..t...h........ls+++VtRLM...+.p.hGL....pu......h.h...+..++t	...............................ttp......l.p.pt......ltplap....cp...pt...........sY...GhR.+lt......t..tL.p......c................p..........t...h.......ls++.+VtRLM...+.phuL....ps.....p..h..+.tc.....................................	0	514	1189	1570
+13119	PF13277	YmdB		YmdB-like protein	Bateman A	agb	Jackhmmer:B5ZC04	Domain	This family of putative phosphoesterases contains the B. subtilis protein YmdB Swiss:O31775.	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.62	0.70	-5.36	140	1315	2012-10-02 19:15:56	2010-08-27 17:30:23	1	3	1256	8	347	881	1521	250.70	47	94.97	CHANGED	LFlGDlVG+sGRpslpcpLPpL+cch.plDhllsNGENA.A.uGhGlTtchsccLhssGlDslThGNHsWDp+Elhsal-p.ps.+........llRPhNaPp....ssPGcGht......lhcs..sGp+ltVlNlhGR.lFM......pshs....sPFpsh-pllp...ph.......ttp..sshl......lVDhHAEATSEKhAhGaalDGRlS......sVlGTHTHV.TADppILPsGTAYlTDsGMsGsa.cSVIGhcp-tslc+FlothPp.R...FpsApG..ps..pLsGlhl-hD-pTGcAtpIphlp	.................................................LFlGDlVGcsGRcslpphLPpL+pca.c.shsIlNGENA......A......s.GpG...lT.....ccIhcpll.csG.lDslThGNHsWDp..+.E.lh-.FI-c.t.p.+........llR.......PANaPc......ssP....Gp..Ght........hlps.....Ns....tcl..uVlNL.GR....sFM.........s.sl-..sPFc.ps-pllpph..........pcpsshI......hVDFHAEsTSEK...A.........hGaaLD.....GRsS......AVVGTHTH.VtTADpRIL.....P................pGTAYlTDlGMTGs.Y.DullGhc+-tllc+FlTslPp...+...hps.s.p.G...c..s..hLsGVll-lDc.p..oG+ApcIcpI................................................	0	143	256	301
+13120	PF13278	DUF4066		Putative amidotransferase	Bateman A	agb	Jackhmmer:B5ZBC5	Domain	This domain contains similarities to other amidotransferase families such as Pfam:PF00117. Some members of the family lack the likely catalytic residues.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.82	0.71	-4.98	51	5657	2012-10-03 00:28:14	2010-08-27 17:42:27	1	16	1638	20	2096	9111	779	160.80	25	54.62	CHANGED	Lsa-.GFs-lDhhhshslLspsp........t.t...aplplsusssp.Vp..........Sh.sGlsl.tsptsLpp...sspsD.sVL....lsuGhp.....pthssc.stlhspL.phc................stt...phluutCoGshlLAchGLLsshsAsTchpspshlppttspVh...sp.asssG.........slsTAG.Gsluuh.Luhallt	......................................................................................hhsshphhshsssh-.sh.thss..................................t....ha...p.h...p...l..h...u......s......s.....s......s...l.p.........................................s.s....s.....G.....l....p.....l......s..s....t.s..h..ss................hs..p.....s...D....h.....ll.................V..s.G.uhs....................t.t.h..ts...t....tl....l.....s.....h....l...p.p.tt......................................tpu.......thlsulC.o.G.u..a.l.L.At.A.G.L.L..c...G...+..c.A..T.....T.......H.......W............t..........h............h.......s.......t.......h...t..p...t......a........P....p....l....p....h...t...............s...t.....h...a...l....p...D.u............................................................s.lhTu.u...Gss...A..ulDhsLtll....................................................	0	461	1105	1633
+13121	PF13279	4HBT_2		Thioesterase-like superfamily	Bateman A	agb	Jackhmmer:Q7P2C3	Domain	This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily [1].	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-11.44	0.71	-3.66	179	4845	2012-10-02 20:54:35	2010-08-31 15:04:51	1	19	2807	37	1526	6021	3343	126.80	18	76.66	CHANGED	Vt.s-.hDh................................t...Hh....s..sspYl......................t.h....hpt.up..............phht...............hsh.....thhttt...............th..................uhhhsps....plpah..p........................plp.hs-p.h.........lp..............hpl..hs........hsppphthhhph..............hp..............tsp...h...............Apspthhhhh.shpp.................................................................................ssshP......pt............ltptl	..............................................................t-.hD............................hhs.Hl....s....NupYh......................pa....h-p.ARh...............................................................phh.p..................phsh..........hp.hptp....................................s.h.............................shl.lsch........phpYh..p..........................lt..hs-p..l..............plp.................spl.....hp....................hssp..php.hp..hp..l............hp.................................ssph.....s.........................................up..uph.h..hlhl..-hps...p................................................................................................hs.....................h.h..........................................................................................................................	0	432	883	1254
+13122	PF13280	WYL		WYL domain	Bateman A	agb	Jackhmmer:Q7P457	Domain	This presumed domain is around 170 amino acids in length.\	\	   It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule. There are a number of proteins that contain two tandem copies of this domain such as Swiss:Q47P13. This suggests that this domain may form a dimeric arrangement.	25.80	25.80	25.90	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.14	0.71	-4.39	746	6059	2010-09-01 09:50:02	2010-09-01 10:50:02	1	38	2680	0	1655	5249	711	156.10	17	51.55	CHANGED	p.h...l...p.........t.......lt....pAltppc...tlph.....pY..ps..................................pptp.....p................R.p....l..........c.........PhtL.h..h..p..p..s..p..WYL..hu....h........s..p.............................p.......c...........p.........s................h..R...........tF+..lcRl....p..s..lp....hh..s.....p..................................ph..p.......hs...sh....c.......l......p........................p..hh.p......p........h..h.....t..hht................t...hp..l......pl............c..h.........s...sps...sph........lh....p....p.......hh.......t....s.............t.p..........................lt...............p.....ps..........ss.t.h........h.....hp.h...p.....h..t.s.....p.....t.....h.h.thlhua.G..s.p..lcVlp....Ptp..L+ppltpphpp.hh	..............................................................................................t..httltpAltppp....hlph.....p.Yps.................................ttptp......p......................................R.p...lp.......PhtL.hh........t...s..s...p.....WY....L..hu..a........st............................................................p......c.............p...........p........................h..R.........sF+..l..sRI....p..s...lp....hh..s..p.............................................th.t..............t......s.........h..t.................................p..h.h.p......p...................t.....................ph..hl............h.h.........t....th......h..h........h....t.............h..................t......................................................h................t.......t..........pt.......h..........h.....hp.h........h.....t....................h..h...h...l...ht..hu...............t..htllt.....P.t....lht.hht.ht.......................................................................................................	0	652	1199	1458
+13123	PF13281	DUF4071		Domain of unknown function (DUF4071)	Aldam G	pcc	Pfam-B_2008 (release 24.0)	Family	This domain is found at the N-terminus of many serine-threonine kinase-like proteins.	24.10	23.40	24.60	24.10	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.23	0.70	-5.61	14	275	2010-09-01 12:57:33	2010-09-01 13:57:33	1	13	141	0	144	258	14	309.10	37	31.02	CHANGED	LhYcLGVRESFphppNIlLas-ss.p...-sh.tl+..h........ushphlPYhlsspu.......thhps.....pttcthh..s.th..sh.shsLsstlhpLlpss.phppstah+Ephhs-lRpA...R-phsu..cpLpctLpclct+LDssplLos-IlhsLhLSYRDlQDYsuMlcLV-cLpsls.h..lssss.lpapYAFALNRRNpsGDREKALpllhph.......lppccshusDhhClhGRIYKDhFhcSshpcpso.....LcpAIcWY+KuFEsp.PstYuGINhsTLLhhsGpcFpps.ELpplu..hhLssLlG+KGsLsphpDYWDVATahElulLApDhtKulpAuEpha+L+sPsWYL+SThpNIpLlcch++phpt....s.c.phhpFWh-h	.....................................................LhYHLGVRESFsMtpNll.Lhppts......th.uL+..h..........usYhhlsYhlssps...............phhsspst.h.....pthsphh..s.........t........hhsL.sRhhp..lLpsh.php..S..p..t..ah+.E.phhpD.lRpA....Rphapu..........p....pLtttLtclptRlD.s..c.lLos-llh..slLLS.YRDlQDYsuhlcLV-sLphlPshc.hsp....p.pl..pFpYuFALNR...R....N..sG.DR...t+ALplhl.h............lpp.p...tp.....sssD..hhCLsGRIYKDh...Fl.cS..sh..p..Dsps..............h-pAh.pWY+...KuF-hp..s..........sh...auGINhAs..L...Ll......huG.......p.....p...Fc..............so.E.............Lp.p.lG........hpL.ssLlG......+...KG.....s..........lpph.ppYW-VuhahtsslL....As...Dhhc.slpAuEpha.KL.p.sPhW..........Y.Lc.S.....hhpslhlhp+Ftt..t......s...phhpFWhc....................................................................................	0	29	48	89
+13124	PF13282	DUF4070		Domain of unknown function (DUF4070)	Aldam G	pcc	Pfam-B_2005 (release 24.0)	Domain	This is a bacterial domain often found at the C-terminus of Radical_SAM methylases.	21.60	21.60	21.60	21.80	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.74	0.71	-4.66	55	231	2010-09-01 13:08:55	2010-09-01 14:08:55	1	4	185	0	116	262	53	141.90	28	27.44	CHANGED	TsLWcRLc+EGRLh.......tpssssQ.sshhNFlPshPh-clsptYhcshhpLY-PcpYhcRshphhhphss...sptph..........shtsL+AlhplhW+.Glhp.cpRhpFW+hLhshlh+pPpsl.hhlslsshucHFhcap.phlpcplcppl	...................TsLacRLc+EGRLl.................pstsssp..s..sthNFlP.p.hPh-clhstYhcshtplYsP..ctahcRhhphhtphtss....t..h.t..................s.htsl....puh....hpl.....ha+......G.l....ht..ctRhtFW+hhhthlh..+...s...P..t..h.hthhlshshhscHahpat.p.shpt.t...h...................................................	0	33	79	103
+13125	PF13283	NfrA_C		Bacteriophage N adsorption protein A C-term	Aldam G	pcc	Pfam-B_2015 (release 24.0)	Family	The function of this domain is unknown but it is found at the C-terminus of bacteriophage N4 adsorption protein A, in association with an N-terminal region of TPR repeats.	25.00	25.00	34.10	45.50	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.88	0.71	-4.91	14	355	2010-09-01 13:23:58	2010-09-01 14:23:58	1	21	350	0	31	204	0	175.00	65	19.09	CHANGED	sps.susTGhsTsQGulGsRaKPlpstNLllssp...RhhtlG.shutsDWLLRhuYS....ss.Gs..DL+VstPsWhohplYsEuuaalppsphh.sssEuchG+oaRlsuhss+LslhPassluusaDostssp...hAlGuGsGlshRaWFREscYsAPtSalDlolQYRhpLsss-.RucGlhhcAs	.................G.ENGVMMPVKNPMSGTGLRWKPLRDQIFFLAVE................QQLPLN.GQNGASDTMLRASASFFNGGKYSD......EWHPNGS..GWFAQNLYLDAAQYIRQD.IQA.WTADYRVSWHQKVANGQ...TIEPYAHVQD.N.........G....YRDKGTQ.....................GAQLGGVGVRWNIWTGETHYDAWPHKVSLGVEYQHTFKA..IN..QRNG......ERNNA....	0	2	9	18
+13126	PF13284	DUF4072		Domain of unknown function (DUF4072)	Aldam G	pcc	Pfam-B_2021 (release 24.0)	Family	This short domain is normally found at the very N-terminus of Hyrdrolases Pfam:PF00702.	21.90	21.90	21.90	23.70	21.60	21.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.11	0.72	-3.78	23	106	2010-09-01 13:49:34	2010-09-01 14:49:34	1	2	105	0	40	85	2	47.80	41	16.54	CHANGED	LllQSss.LusschcsLssLupusplpp.lsspAhRltsA..ssspRs-lc	LVlQSsuPLSsuHt+sLsALucusclst.lsspAhRltsA..ssupRsDlD......	0	5	19	30
+13127	PF13285	DUF4073		Domain of unknown function (DUF4073)	Aldam G	pcc	Pfam-B_2039 (release 24.0)	Family	This family is frequently found at the C-terminus of bacterial proteins carrying the family, Metallophos Pfam:PF00149.	25.00	25.00	25.30	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.92	0.71	-4.80	8	102	2010-09-01 13:49:58	2010-09-01 14:49:58	1	6	101	0	3	91	0	136.80	62	22.17	CHANGED	LNLPDWAGKKKIsG.GDcKGFTVVNTGGIETGWMSAGPNGGEKTAPDGhSFKQGLQVKAYGNDVVVTAYDYKRDKsIKKLLISDuKIAQMAPDVTADDsKNVIVGATEYMEYoVEGTNEWpTYs.usPPKFDGDKlVYVRHKGEMNLEPGLTQLLRFSs	..................LNLPDWAGKKKItG.G.Dc...KGFTVVNTGGIETGWMSAGPNGGEK.TAPDGYSFKQGLQVKAYGs.DVhVTAYDYKRDK-IKKLLISsSKIAQMAPN.VTADDoKNIIVGATEYMEYSl-GTsEWhTYs.uNPPKFDGDKhVYVRHKGEMNLEPGLTQLLRFS.s..............	0	1	2	2
+13128	PF13286	HD_assoc		Phosphohydrolase-associated domain	Aldam G	pcc	Pfam-B_2016 (release 24.0)	Domain	This domain is found on bacterial and archaeal metal-dependent phosphohydrolases.	22.20	22.20	22.30	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-10.30	0.72	-3.71	344	2449	2010-09-01 14:47:52	2010-09-01 15:47:52	1	4	2227	6	684	1967	1173	91.00	22	22.24	CHANGED	lshssp.httthptLKpFlapplYcpsplpphpt+uppllpcLFph....a...hs......c...sp.hLPspaptth....ppssp.........tptRllsDYIAGMTDpaAlchapc	.......................................................................................h..hs.thttththL+phhhphlhpp..p.h..th.p.h..p..s.ppllppLhch....h.....hs...........................................c...sp.hLs..t..p..h.t..thh...............................pttt...................t+hRllsDYIuGMTDpaAhc.app............................	0	235	468	581
+13129	PF13287	Fn3_assoc		Fn3 associated	Coggill P	pcc	Jackhmmer:O26995	Repeat	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.10	0.72	-3.88	342	282	2012-10-03 16:25:20	2010-09-01 16:25:02	1	69	219	0	75	1442	337	63.70	33	7.78	CHANGED	VsLo.o..............spsA.....sIYYTlDGosP....T.s........pSsh.......Y...........s.sPIhl......sp.........ss.s...............................l..KAhAhcpu....hssSslsohsa	....................pLp..o..t...stsu......pIaY.Tl.DG.S.sP.......s..p.............................pSht.........Y...........................s..ss.I.hl......sc......ss..s...................................................................................................l...KAlAhcpu.....hppSslsoh...........................................................	0	29	55	68
+13130	PF13288	DXPR_C		DXP reductoisomerase C-terminal domain	Bateman A	agb	Jackhmmer:Q7P3U3	Domain	This is the C-terminal domain of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme. This domain forms a left handed super-helix.	27.00	27.00	27.20	27.30	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.49	0.71	-4.10	236	3405	2010-09-01 15:25:30	2010-09-01 16:25:30	1	7	3273	79	826	2642	1652	119.10	39	30.61	CHANGED	LGsPDMRhPItYALsaPcR..h.........s..s......ss.ptL.Dhs..pl.up.LsFc.pPD....hc+FPsLpLAh-Ahct..GG..shs.slLNAANElAVpuFLpt+IsFh-Iscllcpslpp..........hps.t..................ssL-sllpsDphARphA	............LGsPDMRhPIuaulua.PcR...l..............s...s......s.s.psL.D..hs......cl....u........s.Ls..Fp.tPD....hc+FPsLcLAh-Ahct......Gs..shs.slLNAANElAVsAFLsp.cItFh-Isplltpslcp...............hsht........................sssl--lLp.hDt.ARch.......................................	0	289	560	710
+13131	PF13289	SIR2_2		SIR2-like domain	Bateman A	agb	Jackhmmer:Q7P447	Family	This family of proteins are related to the sirtuins.	24.50	24.50	24.50	24.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.94	0.71	-4.31	164	1624	2012-10-03 09:55:27	2010-09-01 16:29:03	1	38	1214	0	458	1490	86	152.60	17	27.46	CHANGED	ptllTTNYDsllEpuh.....tptstthh...........................hhspshtt.....................pssphhlhKlH.Gsl............t....s......................psl.llopsc...........Y...tphh......................psh.htphlp...shh.t...sp.....sllFl..GaS..hsDs.slppll....pplhpphss..............pt....ahlh.pst.................tttpt......hhpphslphl	.............................................h..llTTNYDphl.E...psh...........pptshth..........................................h.hpsht........................tpthhtlhKlH.Gsh................................................................................................psl...ll..o..p..s.c.................................Y....tchh........p..........................................................ps...ht..phlp.........shh..p.....sp......sl.lFl..Gao...h..s..D...plp..t..lh...pphhpphtp................h.........ahhh.tt...........................................................................................................................................	0	165	285	360
+13132	PF13290	CHB_HEX_C_1		Chitobiase/beta-hexosaminidase C-terminal domain	Coggill P	pcc	manual	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-9.68	0.72	-4.19	268	225	2012-10-03 16:25:20	2010-09-01 16:33:34	1	57	161	0	67	1534	350	68.50	26	8.39	CHANGED	sssG.php................st..plslps....sssss.....sIhYThD.GosPoh.........t...S......hY...............t...............s..l.l......t.ss.....ss....l+shuhsss.tps..u.tlh..o	....................t.............pstlplss............sss.ss.....pIaY.ThD.G.o.pPoh..........................p.......S...........hY..................p..t..................................P....lpl..................s..ts........................ss...............lcshshp.s.sp................................................................	0	33	48	57
+13133	PF13291	ACT_4		ACT domain	Bateman A	agb	Jackhmmer:Q7P344	Domain	ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.22	0.72	-3.64	182	5583	2012-10-02 00:29:19	2010-09-01 16:38:22	1	27	3945	4	1173	4363	2094	78.80	25	11.21	CHANGED	sspp.....apsslplpu.hDcpGlLs-lspslupp.psslps.lshps.........pthsphplslpVpshppLpplhppl+plpsVhpVpR	..........s..tta.splclpu.hs.R.pGlLs-lspslusp..psNlhu.lsscsp..p....sphushplslp...l..p..s....h..p....p.L..spllp+l.+plss.VhpVpR........................	0	347	739	993
+13134	PF13292	DXP_synthase_N		1-deoxy-D-xylulose-5-phosphate synthase	Mistry J	jm14	Jackhmmer:Q7P481	Family	This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyses the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6).	21.20	21.20	21.20	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.84	0.70	-5.46	331	4453	2012-10-02 16:07:47	2010-09-01 17:03:14	1	13	3512	8	1043	7165	5251	238.80	43	43.01	CHANGED	L-pIssPpD.L+pLshppLtpLApElRphllcsV.Sp.....oGGHLuuNLGVVELTlALHhVFsoPc.D+llWDVGHQuYsHKlLTGR+.-papolRphsGlSGFPcRsESt.aDsFssGHoSTSISAALGhAhA......pc.l.p....G...p.........s.....ppVlAVIGDGAhTuGMAaEALNpA..Gph.p.p..sllVlLNDN-MSIu...........NVGulu.paL...sclhs...sth...Ypph+ptscphl.p.....hh.......hhphhc+h....ccshKshh...h....s......slFE-hGhpYlGPlDGHDlppLlpsLcps+......s.....h....cG.PlllHVlT	.........................................................................................................................ttlpsP.t-L+.tLsh......ppL..pLu...p...ElR.p.h...l.l.p...s.V...S.p.....o.G.G..H.....huusLGs.........V.........E..L.........T.........l......A.....L.........H.........h.........V.........a..........s..........o..........P.........h........D.p..llW..D.....V.....GH....Q....u.......Y....s.....H.....K...I......L....T.....G.....R......c........c....p.....h.....t.....T......l....R......p.h.....s....G.......l....s....G...F....s....p......R.......s......E...S.......p..a.D......s......h.....s.....s.......G.H.....o...S..T.....S....I.SA......u.l.GhAh.A......tc..hp....G..p....................p.....cps.l.uV..I..GD...GA............l.TuGM.AaE.A.h.Np.s....G..t.h...c.t...........s.hl..l.l.L.ND.N...-...M..S..Iu.....................s..V..G...u...l..s.........p..a..L........u..p.l.h.......s.......s...ph...........Y.p..p..h.+...p.th..c..phh..p.................tl.......h.hphhc+h..............cc.t.hKsh..hs........s..sslFE-L..GhpY..lGPlDGH.slttLlpsLcph+...............p.........h.....p.G..PhllHlhT.......................................................................................................................	0	343	706	895
+13135	PF13293	DUF4074		Domain of unknown function (DUF4074)	Aldam G	pcc	Pfam-B_2050 (release 24.0)	Family	This family is found at the C-terminal of Homeobox proteins in Metazoa.	22.30	22.30	22.60	43.30	22.00	19.10	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.13	0.72	-3.75	14	230	2010-09-01 16:25:41	2010-09-01 17:25:41	1	5	74	0	87	199	0	64.30	67	16.92	CHANGED	PsoGPulFGLsHL....PHssossMDY.sGAssMusupH.H........GPCDP..HP.TYTDLosHH.sSQGRIQEAPKLT	.............PsSGPulaGLsHL....sHssSushDY.sGAsshuuspH.H........GPCDP..HP.TYTDLouHH......sSQ...GRIQEAPKLT.......	0	3	10	35
+13136	PF13294	DUF4075		Domain of unknown function (DUF4075)	Aldam G	pcc	Pfam-B_2028 (release 24.0)	Family	The members of this family are putative mature parasite-infected erythrocyte surface antigen protein from Bacillus spp.	25.00	25.00	65.40	27.80	17.80	17.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.81	0.72	-3.94	12	77	2010-09-01 16:37:33	2010-09-01 17:37:33	1	2	76	0	3	33	0	77.00	93	46.08	CHANGED	KETKEIFSKKKlEstEKPETIEIQAVSPKVDELKAEEEPVVAEDGGMKEARELFMKDSNAEEKKTEAYIELKQDKEEKK	..KETKEIFSKKKVEPtEKPETIEIQAVSPKVDELKAEEEPVVAEDGGMKEARELFMKDSNsEEKKTEAYIELKQDKEEKK....	0	0	1	1
+13137	PF13295	DUF4077		Domain of unknown function (DUF4077)	Aldam G	pcc	Pfam-B_2043 (release 24.0)	Family	This is the N-terminal region of methyl-accepting chemotaxis proteins from Bacillus spp. The function is not known.	25.00	25.00	373.30	372.70	21.40	18.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.39	0.71	-4.55	4	74	2010-09-01 16:52:32	2010-09-01 17:52:32	1	1	74	0	2	55	0	175.00	95	34.95	CHANGED	MEWLKRTCFSNLEKESQKNHLLLFITICSFFLGIIAIGYYGYIFTERAIAFWhCGISVVVFGTLhTFIcSMEuhYKYIMTFMLLhMSFIMVQAFNESPAVFQMVYFTLAVSLIYLSERLllILGGVAVVlTFILCSYWPEQFFAYTAuSEAANFASLLAIVTIAMWGVTKIGSNL	MEWLK+TCFSNLEKESQKNHLLLFITICSFFLGIIAIGYYGYIFTERAIAFWlCGISVVVFGTLhTFIcSMEohYKYIMTFMLLhMSFIMVQAFNESPAVFQMVYFTLAVSLIYLSERLllILGGVAVVITFILCSYWPEQFFAYTAuSEAANFASLLAIVTIAMWGVTKIGSNL	0	0	1	1
+13138	PF13296	T6SS_Vgr		Putative type VI secretion system Rhs element Vgr	Aldam G	pcc	Pfam-B_2052 (release 24.0)	Family	This is a family of putative type VI secretion system Rhs element Vgr proteins from Proteobacteria.	22.40	22.40	22.50	24.90	22.10	21.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.20	0.72	-4.19	159	943	2010-09-02 08:37:27	2010-09-02 09:37:27	1	14	320	0	249	1034	26	106.20	38	12.58	CHANGED	S+phtG.ss..hNpLhhDDssGQ.pspLuo..sa.upSpLsLGaLsct..tsptctphRGpGFELRTDuaGAlRAupGLhloocspstAt....up.LDhspshppLppAtphhcsLups.A	............o+phtuss..hNpLhhDDssGp.+hpLuo.....sa..upSQLNLGaLsct..tsp.ptp.RGcGFELRTDuaGAlRAupGlhlSocspsp....Ap....uphL....Dhstuhp.....LpputphhcuLupsA....................................	0	24	77	152
+13139	PF13297	Telomere_Sde2_2	DUF4076; Sde2_C;	Telomere stability C-terminal	Aldam G	pcc	Pfam-B_2053 (release 24.0)	Domain	This short C-terminal domain is found in higher eukaryotes further downstream from the Sde2 family, Pfam:PF13019. It is found in all Sde2-related proteins except those from fission yeast, fly, and mosquito. Its exact function in telomere formation and maintenance has not yet been established.	21.80	21.80	21.90	23.80	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-8.83	0.72	-4.70	33	282	2010-09-02 08:39:50	2010-09-02 09:39:50	1	10	133	0	179	257	4	59.10	58	13.20	CHANGED	lDLssasSscELE.sLGl-RLKptLtuhGLKCGGTLpERAsRLF.lKupsh-clD++lhAK	.....lDLssFoShE.....ELt....sLGL-RLKsALhALGLKCGGTLpERApRLFSsKGpsh-plD.sLhAK.......	0	62	92	138
+13140	PF13298	LigD_N		DNA polymerase Ligase (LigD)	Mistry J	jm14	Jackhmmer:Q05W82	Family	This is the N terminal region of ATP dependant DNA ligase.	25.00	25.00	34.50	27.40	21.80	20.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.55	0.72	-3.93	134	675	2010-09-02 12:44:19	2010-09-02 13:44:19	1	11	606	8	296	710	139	106.30	50	16.03	CHANGED	QcH.....cAp+..LHYDFRLEh-GV.LtSWAVPKGP...oh-PssKRLAlp.sEDHPlsYssFEGsIPpGpYGuGs...VhlWDpGsac.sh.............pstp............th..............pcG.clphpLcGc+Lc.G.casLlR	...........QcHcApR..LHYDFRLE....hDGV...LtSWAVPKGP....ShcPs..............sKR..LAVc.....sEDHPL-YusF....EGsIPp..GpYGuGs...VhlWDpGsap.s......................s.tp...........sh..................................cpG.clphpLcGc+LpG.pasLlR......................................................	0	77	177	244
+13141	PF13299	CPSF100_C		Cleavage and polyadenylation factor 2 C-terminal	Aldam G	pcc	Pfam-B_2065 (release 24.0)	Family	This family lies at the C-terminus of many fungal and plant cleavage and polyadenylation specificity factor subunit 2 proteins. The exact function of the domain is not known, but is likely to function as a binding domain for the protein within the overall CPSF complex [1].	22.30	22.30	23.40	22.50	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.07	0.71	-4.05	58	300	2010-09-02 13:14:05	2010-09-02 14:14:05	1	16	262	0	216	303	3	149.10	29	18.79	CHANGED	V+LscsLlppL..+Wppl......cshpVutlsGpLt.............................................................................ht..t.p..pttsptptpsthchlss.....p.s..ssthss.spslalGDlRLuDL+chLts.....pG..hpAEF+.u-GsLllsst...........VuV..RKsus...............GcltlEGshs.....................ssaatV+chlY-tL	..................................................VpLpcsLlppL..papps......cshplshlsG.Lt..................................................................................t.....ht...............t.t..sppp.....shlss................h.s..ssphss..ppslal..G-lRLuDhKphLhp.....pG....h.pAEFp..tGs..L.l.s.sst...........................................VuVR+sss...............Gc.ltlEGshs..............................psaYplRchlY-th....................	0	72	116	178
+13142	PF13300	DUF4078		Domain of unknown function (DUF4078)	Wood V, Coggill P	pcc	Pfam-B_3305 (release 24.0)	Family	This family is found from fungi to humans, but its exact function is not known.	25.00	25.00	26.80	26.80	22.30	18.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.01	0.72	-3.86	34	194	2010-09-02 13:35:35	2010-09-02 14:35:35	1	4	176	0	149	186	0	87.80	36	21.56	CHANGED	ppMpplAc+RD+s.T.P..phHY-ust..ElRs+GsGFYuFS+DEcpRccQM-cLpptRpc.TpccRc.pRcct+tcRcchhc-Rhcclcpc+	.......................h.phpphtcccccshp.P......sshHY-s.t....EsRs+GsGaYuFS.p.DE-pRpcQMcpLcphRc.p.TpcpRp....cR......c....p....h......+ccR....cthlcpRhtclcp++.............................	0	49	73	117
+13143	PF13301	DUF4079		Protein of unknown function (DUF4079)	Mistry J	jm14	Jackhmmer:Q05X76	Family	This is an uncharacterised family of proteins.	25.40	25.40	26.10	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.20	0.71	-4.26	90	277	2010-09-02 14:02:26	2010-09-02 15:02:26	1	3	104	0	136	293	83	147.20	27	80.26	CHANGED	ahth...........lHPllMhll.aslsshshhLGhphRppRstps.......................................................................tphtpLl...pschpt....hHaphu.hlLshhslhslGGhsssahpssp....lFhus.HhasGluhssLhhhSsulsPth..p....up.p.thRplHlsLNslslhLFhhQulTGhcllhcl	................................................hhHPhhhhhh.hshshh.shhhGhphRphR..tt...........................................................................................h..hh.......hhph+ptHhphushhls.hhslhhlGG.hssshhpssp......la.us.HhhsGhshssLhhhusulssth..psp...p.hhRt.....hHlhLNshhhhLFhhpuhoGhpll.ch...........................................................	0	30	94	126
+13144	PF13302	Acetyltransf_3		Acetyltransferase (GNAT) domain	Bateman A	agb	Jackhmmer:Q7P3G3	Domain	This domain catalyses N-acetyltransferase reactions.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.03	0.71	-4.02	406	20736	2012-10-02 22:59:21	2010-09-02 16:53:55	1	153	4229	65	4844	27191	2993	139.30	19	68.41	CHANGED	RLhLRs.h.p....s...Dhsslh.phh.s..s.....sc.lh....ca.....hs.....shppspphl....t..............htt.http....s.hhh............aslt..........................t+s....s...........t.................p.....h.lGh.hul.................ht.............................tspsE.lG.ah.....ltps.hh........Gp.GausEAspshh......pas.....h.p....phs......h........................p...................pl.huhhts..pNhsStpl.hc+hGhp	......................................................................................................................................hhL+...h..p.....p.....D....h....t....t...h....h....phh...s.......s.................p...hh........pa...........h..h.................sh.....p.p....h..p..p...hl.....p...........hhtt..ppt..................hh......................a.s.lh..............................................................................................pcp...s...................t..............................................p..................h..lGh..lsl...........th....................................................tppps-...l.G....a.h........l.s...tp...at.....................Gp...G.h.u......s....-Ah.pth.l................cau......a..p......................phs.................l.................................................p..................+l..hh.ps..t.s........pNh....sS...t+....l..h.c.+.hGF........................................................	0	1518	2985	4028
+13145	PF13303	PTS_EIIC_2		Phosphotransferase system, EIIC	Bateman A	agb	Jackhmmer:Q7P503	Family	The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyses the transfer of a phosphoryl group from IIB to the sugar substrate.	27.00	27.00	27.00	27.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-11.97	0.70	-5.58	67	1977	2012-10-01 19:13:17	2010-09-02 17:03:21	1	3	895	0	191	1006	7	317.10	29	92.29	CHANGED	hcsLsGhAhullsuLlsusllpplsphlhh...........s...................hlhplsslspthhusulGsslAhthphsslhshusshAuhlGussh.h.....................tth...hhuhGs.lsshlsuhlAshlsphls....thsslclllhPllshhluuhlGhh.ltPhls.hhphlGshIsssoshpPllMullluhlhulllsoP.lSSsAlulAluLsG.....................luuGAAslGssushh..shshhoh+.NshGshlAhhlGosKlQhsNll+pPh.lhlPshlsuAlsGslushh........slp..ssssuu...GhGhsGLlGPlssh.................s.us..ss.hlhhllhhhllPhlluhlhthlh.........................+phthh+ss-.hpl	................................................+sLuulAsuhls.uLlssAlLttlhth..hhth..........p..........................hLhp.lush.h..t..uhsuhhlGsLlAhthshsPlhshllusushhus.......................................htGhGcllsshlsuhlushlhphlp....pt.sul.-....lIlhPllsss.l.ushluhl.lhPhlpshhptIGshIpshTshpPllMuIlluslhullhhoP.lSosA..lshhluLoG.....................luuuu.AslGssussh..shlhtsh.+lNs.hG......sslAlslss...shhp...hsslhpp.Pl.Ihlss.hlsuslsGllsshh........slp..ssstuu..............GhGhsGhlu.lshh.....................ss.hs..lllhllshhll.Phlsualsphlh.+hhtlhppt.h................................................................................................	0	71	123	178
+13146	PF13304	AAA_21		AAA domain	Bateman A	agb	Jackhmmer:Q7P3F0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.96	0.70	-4.45	220	6048	2012-10-05 12:31:09	2010-09-02 17:17:35	1	63	2772	13	1685	97673	27953	227.70	14	53.08	CHANGED	lsslhGsNuoGK..Ssllculthh.......................................ththh.hhhptpthptshphpht.hhtpshpaphthphpppth..................t.htthhh.ptt.t.th.th..t.ht.tt.ht..hhh.hthtt...hh.hthhh.hht.h..h........................thphhphhpphhhtpphhphhphhhptht.hththtth................................................................hhhh..ttth.h.h.t......SsG...ppph.h..slhshlhpshtt.....................sl...ll....lDEh.-ss.LHP....phh....ppll.....phh.............pptpp...............................tsQl.lhoTHs.shl.ls	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h....htth..............SsG.........ppph.h..........hlhhhlh.p...t.t.........................................................................................sl.......ll.......lDEP.Ess.LHP.....................ph.........pplh....phl................pphtp...................................ts.Q.l..llsTHu.s.l.l..............................................................................................................................................................................................................................................................................................	0	627	1112	1447
+13147	PF13305	WHG		WHG domain	Bateman A	agb	Jackhmmer:Q7P3F5	Domain	This presumed domain is around 80 amino acids in length.  It is found to the C-terminus of a DNA-binding helix-turn-helix domain. This domain may be involved in binding to an as yet unknown ligand that allows a transcriptional regulation response to that molecule.  The domain is named WHG after three conserved residues near the C-terminus of the domain.	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.76	0.72	-3.41	239	2407	2010-09-03 08:44:01	2010-09-03 09:44:01	1	6	1383	8	710	1956	289	84.90	20	41.89	CHANGED	tshutuYlpFAhppPshaclhF...........ttp.h...................ps...sphpp.h....h...........p..............hhtph...lpp.h..h..tt........hthst......pc...sp.phshs...hW..uhlHG.husL...hhs......sth	.............h.thuhuYlpFAhccPshachhF............ttshs.................................................tt......tphpp.s....h..............p.................................thtph...lpp.h..h..tt....................hth..ss.........................pp...st..thsht...hWuhlHGhss.L.hhss..h............................	0	225	496	610
+13148	PF13306	LRR_5		Leucine rich repeats (6 copies)	Bateman A	agb	Jackhmmer:Q7P2P7	Family	This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.90	0.71	-12.10	0.71	-4.44	205	12012	2012-10-02 21:32:02	2010-09-03 10:37:11	1	746	915	12	6389	30082	1356	113.30	19	48.31	CHANGED	spIs..stsF.hs.s.sLp.s.ls.lP..s..s..lp..p....IuptuFtsC.s.Lp..sl.p..l..Ps..s..lppIustuF.ts.C.s.L.psl.sl.....s.s..s.lppIs.pt.sFptCs..s..Lp.sls..l..s..s..s..lp...pIupt.s..F.ts.s.s.L.p.sl.s.ls.s..slp...pI..ss.ps...Fps.C..sLp	..........................................................................................................................................................................................................................................................h.p....p.....l......l..s........p.....s.........l..p...p...............I.....s.......p........t........s........F..........t.........s....s..........................s.....Lp...........p......l....p.........l......s..s........s..............l...p......p......I........s........p........t..........u.......F......t...s.....s.....................s......L.........p....p......l.......s.l.............s....s....s....l........p........p...........l..........s........p.......t..........s........F......t...t........s.s..........p................L........p..........p........l.....p.....l..........s.....p...........s..........l.p.............t..l...s.......t.................s............F.....t........t....l........t...........h.........h...................................................................................................................................................................................................................	0	5510	5860	6131
+13149	PF13307	Helicase_C_2		Helicase C-terminal domain	Bateman A	agb	Jackhmmer:Q7P4K4	Domain	This domain is the second of two tandem AAA domains found in a wide variety of helicase enzymes.	25.10	25.10	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.04	0.71	-4.30	152	5901	2012-10-05 12:31:09	2010-09-03 10:41:35	1	61	3620	5	1731	4652	739	165.30	27	22.05	CHANGED	lhplh.p.t.hs..ussllhFsSaphhpplhp.t.h...pp............p..h..................th.........t.lh..h..p................s...pt..s..tppll.................ppap....p......s....................................psu.l.Lhust....ph...EGlDhs...sct..hpsVll..stlPa..........ssspsshhpt+tpahc.p.....pt.....................................................tss........hp..p.hhhspAhtplpQuhGRlIRpps...DhGsllllDpRht...p.....pp.htpt.l.....phltst	..............................................................................................h...hhphtt..sthllLFsShphhpplhc.h.h...pp..............................................p.h..........................ph..............ll.hQ.......................................s...pt..sptpll.................pp.Fp..p........s.........................................................................................psu..lL..l.uss...u.....FhEG....lDlt...G....c...t......lpt....V....lIs+lP.F...........................sssssP.....lhps+h.chhc.p.....ps.....................................................................................................................tss...........Fp.p.h.tlsp.Ahh.p.lpQ..ulGRLIRs.ps...D...pG.s........l.l....lh.............Dp............Rlh...p........pp...Y.s...pth..psls..h.............................................................	0	576	1031	1435
+13150	PF13308	YARHG		YARHG domain	Bateman A	agb	Jackhmmer:Q7P768	Domain	This presumed extracellular domain is about 70 amino acids in length. It is named YARHG after a conserved motif in the sequence. This domain is associated with peptidases and bacterial kinase proteins. Its molecular function is unknown.	21.30	21.30	26.20	26.10	19.10	17.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.68	0.72	-4.44	105	463	2010-09-03 15:16:03	2010-09-03 16:16:03	1	33	361	0	77	396	21	81.60	28	22.53	CHANGED	sphhh.sp...sssphlspsplpshs..sp-LplhRNpIYAR+GhpFps.tplpsYFs.spsWYpssh..........................pshLsshEppsl...p.hlpphEp	...................................t....h.t....s.phhs...pplpths....ppcLclhRNEIYAR+GahFps.t-hp.pYFs...pps..WYpssh.........................sshlochEppNlc.hlcphp.......................	0	38	61	67
+13151	PF13309	HTH_22		HTH domain	Bateman A	agb	Jackhmmer:Q7P8J8	Domain	This domain is a helix-turn-helix domain that is likely to act as a DNA-binding domain.	29.60	29.60	29.70	33.10	29.30	29.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.77	0.72	-4.21	187	1886	2012-10-04 14:01:12	2010-09-03 16:51:08	1	5	1465	0	294	997	44	63.90	37	28.64	CHANGED	-hlpphl.ppslp.ph.stss....shhsppc+hpllptLpcpGlFtlKsusstVAptLslS+hTlYpYLc	.............................-llsphl.cpslc.pl..sssh....sl.spscp+pI....VhpLa-+GlFplKcAlspVAcpLsIS+tTVYhYl+...	0	75	143	221
+13152	PF13310	Virulence_RhuM		Virulence protein RhuM family	PIRSF, Bateman A	agb	Jackhmmer:Q7P417	Family	There are currently no experimental data for members of this group or their homologues. However, these proteins are implicated in virulence/pathogenicity because RhuM is encoded in the SPI-3 pathogenicity island in Salmonella typhimurium [1-2].	27.00	27.00	27.10	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.72	0.70	-5.38	118	1101	2010-09-03 16:18:37	2010-09-03 17:18:37	1	10	730	0	253	1002	83	187.10	38	65.40	CHANGED	cusl+cathstp-Gp+.....tcplpaYNLDsIIuVGYRVpShRuTQFRpWATphL+EYllKGFlhDDERLKsss......hstDYF-ELLERIR-IRuSERRFYQKlpDIYA.sSlDYDssuptTppFFupVQNKLHaAlpGpTAAElIhpRADupKspMGLToW+su.....+.lpKsDVslAKNYLsccElcpLNRlVohaLDaAEhpAcR+hsMsMpDWtp+LDpFLphs-pclLpsuG+lSpctAcppAcpEa-cachpp......php.sDa-	............................ushpphhhstt-Gpp........hp...hpaYNLDsIIuVGYRVpS.+u..T.pFRpW.A.TphL+-YllKGashsc..c.RL+pss.......paacchLtclR..p...IR.SEt.hh.a..pl.h-lat.hu.D....Yp...p...s..Fat.hQ.Nh..hhauhtt.....Tus-ll..pss.....huh.thttt.........-h.hu.KNYLt..ph..ht.....hht.hp..h.tt...h.ht.h...hp.hh...t..hL.t...Gthp...h...s................................................................................................	0	95	189	225
+13153	PF13311	DUF4080		Protein of unknown function (DUF4080)	Ellrott K	kellrott	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering  human gut metagenomic sequences [1].	22.90	22.90	23.10	23.40	22.50	22.70	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.56	0.71	-11.24	0.71	-4.27	54	385	2010-09-03 18:13:29	2010-09-03 19:13:29	1	5	375	0	101	364	15	171.30	22	30.98	CHANGED	uccaGhlYpstsPYEVLpTcaLSYc-ll+LKplE-hlEhYYNSupFspolcalhppa..soPFchYppLucaa-ccGahphs+uptphYclLh-Fh.........p......-pthc..t..hh+-lLpaDahhppp..t+shPpFh.tppppt.cpp.hpth.hpctpthph.....ht......pphh+hsHlEhFp........hs.................ppp.hlLF	........................ccaGhhYpshPPYElLpochlSap-lhpLKplEchl-tYYNSspFppolchl.h.p.ph.....tssFcFapphu.p.a.apppshhphshuhpchaclLhcFh..........................................p........pph.t......p.phhppllphDahhh.pp..hc.h..Ptah.tt.......p.....p.t...tpt...hhth....hpp.......................t......................................................................................................	0	48	88	94
+13154	PF13312	DUF4081		Domain of unknown function (DUF4081)	Aldam G	pcc	Pfam-B_2088 (release 24.0)	Family	This domain is often found N-terminal to the GNAT acetyltransferase domain, Pfam:PF00583 and FR47, Pfam:PF08445.	21.70	21.70	23.30	21.80	19.20	21.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.31	0.72	-4.11	49	307	2010-09-06 12:54:03	2010-09-06 13:54:03	1	4	306	0	85	197	16	108.80	45	38.43	CHANGED	Gu-lWGhhtt....GtLsulCauGANLlPltu........sssu...lcAFA-+ApcpuRRCSSlVGPA-sVhsLWcpLcs....sWGsA.REVRssQPLhshsssP...tlssDPt........VR.lR.cEl-hll	.............uplaGhh.t....GtLpuLCasGAN...LlPltu......................................sssslcAFA-+Atct.RRsSSlVGsAcsVLsLWcRLp.....sWGsA....REVRssQPLhAhss.pP....plssDst..........VRplp.c-h-sY....................................	0	28	65	80
+13155	PF13313	DUF4082		Domain of unknown function (DUF4082)	Mistry J, Aldam G	pcc	Pfam-B_2054 (release 24.0)	Family	This family appears to be a parallel beta-helix repeated region that sits between successive Cadherin domains, Pfam:PF00028.	21.50	7.00	21.50	7.00	20.80	6.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.85	0.71	-4.76	61	169	2010-09-06 13:08:15	2010-09-06 14:08:15	1	38	53	0	108	198	22	144.50	38	27.55	CHANGED	lasssssPssss.ssD..ssulELGs+FpusssGplTGlRFYKu...suNTGTHoGoLWousGslLAosTFTsE.ouS..GWQpssFuoPVslsAGTTYVsSYaussGpYusossaFsss.hss.GsLpA.....husu.....N..GVYsYuuushFPs..sSapuoNYWV	...................................lasssssPssss.ssD..ssslELGh+FpusssGploGlRFYKu...uss..TGoH.sGsLWou...s...GshLAo.sTFo.sE....ouS...G.WQpssFusPVslsAsoTY.Vs.SYpsssGtY.ussss.aFss........s.hss..usLpu.usu............NGVYtYuus....hFPs..soa.psoNYWV.........................................	0	31	55	84
+13156	PF13314	DUF4083		Domain of unknown function (DUF4083)	Mistry J, Aldam G	pcc	Pfam-B_2061 (release 24.0)	Family	This is a family of very short, approximately 60 residue, proteins from Firmicutes, that are all putatively annotated as being MutT/Nudix. However, the characteristic Nudix motif of GX(5)EX(7)REUXEE is absent.	21.90	21.90	22.10	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.84	0.72	-4.14	10	78	2010-09-06 13:30:24	2010-09-06 14:30:24	1	2	65	0	3	58	1	57.20	60	92.23	CHANGED	M......ltshIYhh..hhllllhussFshhIRhllpsSstKKQc..slEQKLD+IIpL...LEKp	.........l.shIYTCLVIGLIVLFFlSFT..L..F.IRRVLQSSsA.KKppshsMNQKLDRIIEL...LEKD.........	0	0	1	1
+13157	PF13315	DUF4085		Protein of unknown function (DUF4085)	Aldam G, Mistry J	gba	Pfam-B_2570 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 101 and 269 amino acids in length.	24.10	24.10	27.30	37.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.44	0.70	-11.20	0.70	-4.96	7	89	2010-09-06 14:00:34	2010-09-06 15:00:34	1	2	79	0	6	74	1	167.80	52	85.01	CHANGED	KYFs+-aYccMQlpsalpa.Eo.cEWEph.........-ahppLKEEhc.h.p.-LL+aLPcolaPhlpsso.lsothssscLKchhhEWsp-aEtchpplppuYh-paspItc+LPusVtQLa.phSLHDuhIpslc.+scsoLpIhLDsSGsFSpFsKLplTFhslT+sphsENF.-GuWWLYaEItLT-cG.FEhtVLFDsPhc..EloIhA	......................................KYFs+-WYKcMQl.tFlpF..EolcEWpEh...........hpSL+--hE-+.K.DLLKFLPcSlashIps.T...lsS-.YPStcLKKhhhcWopDYEKRhspLppuYh-.as..SIcc+LspNVhQLa.chSLHDu.lpslc+cS....cDol.IsLDCSGoFsEFDKLplTFhGV.oKCShsENF.EuAWWLhHEIsLs--G.FELGVL..FDsPFc..EVhIsA..................	0	3	6	6
+13158	PF13316	DUF4087		Protein of unknown function (DUF4087)	Aldam G, Mistry J	gba	Pfam-B_3066 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 140 and 280 amino acids in length. There is a conserved RCGW sequence motif.	25.00	25.00	34.60	34.40	19.20	17.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.35	0.72	-3.83	11	83	2010-09-06 14:02:00	2010-09-06 15:02:00	1	1	79	0	19	63	0	99.90	52	52.17	CHANGED	suspsEpRCGWh-NPoPANhoLpDc-GpWpIusQG.Ga..pscG...hPs..hssspaVpT.susaGYuCAChslssDscptplspIpps+phPLupCRpDhuL..pc.	...t..spAEpRCGWhpNPTPu....NhhLsDR-GpWpIGTpG.Gh...pscG......Ps..hu.s..sQaVcT....N...GsaG..Y.uCAClTssT.D.pppRlsplhKApthPLStCRpDKpLKEP..................	0	3	10	14
+13159	PF13317	DUF4088		Protein of unknown function (DUF4088)	Aldam G, Mistry J	gba	Pfam-B_3345 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 258 and 300 amino acids in length.	24.10	23.70	214.20	214.10	24.00	22.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.33	0.70	-11.52	0.70	-5.01	4	61	2010-09-06 14:03:01	2010-09-06 15:03:01	1	1	61	0	20	51	0	229.00	80	80.43	CHANGED	RLR+-F-sFlpVSTGLDtpFlPPpFsDFLRARLLQpDGPLTERAV.RLLuuGEYGWA++VFDKQLPNALAuLMRDApRFGFGLAVQs-WoPpQRhcHAR-WAAQlLuEsGADAAaT-ALAuQluASApDlRsLEERM+TPAWRLAESLRQRAYDlMYALQTEssEshGRu+VGELRuhLsLALpYGShQh-EAsRVLEQlcRs+PcLFpEAPDDVFARLAAWLRRhFsps	S.LRKDYDAFVRVSLKLDPQFsTPSFEDFLRAKLLDsMVPLTEHAVQRhLQGGQYAWAKRTLDKEFPDVVuILhRQAG-FGFGFASRSEWTPDELAKACRDWAAAlVupAQGDAuLVDPLAAQIKSAVpDIQTLEEpMQTPAWRLAESLRQRVYEAKLACEMSVGSsA.REKLGELRGLLRLGlAHGSFQKQEAQQIMEYLRLLKPEIFlEEPYDlFsRlAAWLRShFhsu..	1	1	4	11
+13160	PF13318	DUF4089		Protein of unknown function (DUF4089)	Aldam G, Mistry J	gba	Pfam-B_3700 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	21.60	21.60	22.40	22.30	20.80	20.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.21	0.72	-3.66	33	163	2010-09-06 14:03:51	2010-09-06 15:03:51	1	2	162	0	52	131	2	49.60	39	77.12	CHANGED	YlpphutLLuLslcsphRssVlsphp+IsshAp.lhsFPL.s-chEsAsVF	...YlpphtplLuLsLD-spRsslhtpFp+IAshAp.lhsaPL.s-chEhAuVa.......	0	5	23	35
+13161	PF13319	DUF4090		Protein of unknown function (DUF4090)	Aldam G, Mistry J	gba	Pfam-B_3702 (release 24.0)	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	22.70	22.70	24.60	31.70	20.80	16.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.88	0.72	-4.04	15	61	2010-09-06 14:04:41	2010-09-06 15:04:41	1	1	60	0	23	58	101	82.80	63	88.35	CHANGED	GsDAVDpAIusGlDLDGoPIPssMLsLYpcVMsLEupRpRSGVpKSMRNRIVRoGAKHhsp-sLNQhLl-AGW-GLK-KEIuFF	....GsDAlDtAIssGlDLDGSPIPsshL-LYpcVMsLEupRQRSGVppoMRsRIVRhGAKHhsQ-pLNQhLlcAGassLK-KEIAFF.	0	2	13	21
+13162	PF13320	DUF4091		Domain of unknown function (DUF4091)	Aldam G, Mistry J	gba	Pfam-B_3704 (release 24.0)	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	22.50	22.50	23.10	22.60	22.20	22.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.46	0.72	-4.07	63	346	2010-09-06 14:05:22	2010-09-06 15:05:22	1	22	286	0	79	284	31	71.00	34	11.20	CHANGED	hshsGhL+Wuas.ha..sp.......sPap..ss.phth..a.ssGDsallYPGps.........ttshsSlRhchhpcGlpDhchlchLcp	...........................t.phsGhL+WuhN.hW...sc........................-Pht.........Dsphch.......a..suGDshllY.Pusc...........tt.hs.SlRhchLtpGhpDhchl+hlc.p....	0	29	54	74
+13163	PF13321	DUF4084		Domain of unknown function (DUF4084)	Mistry J, Aldam G	pcc	Pfam-B_2026 (release 24.0)	Family	This family of Firmicute proteins is frequently associated with the EAL, GGDEF and PAS families, Pfam:PF00563, Pfam:PF00990, and Pfam:PF00989. The exact function is not known.	22.00	22.00	23.40	23.20	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.97	0.70	-5.18	8	77	2010-09-06 15:42:46	2010-09-06 16:42:46	1	5	76	0	2	60	0	194.50	89	25.51	CHANGED	MINQKKYVHFVhhYIIIFSLWIFLIPK-LNIKEIGILFLFCFAsLFSCYCLYKAIKKMKRGDKLFWVLlLCTCLCGLTMEITLFLHSLSIYDQVIFSYKALPFFIlQYILLFSGFAIKFIKHYSIRGLAQFSFDSIF.IlIMNIYFTLTFILDlSSFRMLTpDTWVLIGYFIAQSLVIYAVISLYRREQYSSSRISLIIGFTIILVYGYIHLFQLNAGhKTSSEVSYLIHTASILLIGLSSILYILDKPMQHETKTKYYRFDYVRFILPYFSIIITFSFIIhQPWDDKFMLIGLVLSLILLFLRQ	..............................................................................................................................................................................................MLTpDTWlL..IGYFIAQSLVIYAVISLYRREpYS..SSRIuLIIGFTIILVYG.YIHLFQLNtGhKsSuElSYLIHTASILLIGLSSILYILDKPhQ...HETKTKYYRFDYVRFILPYFSIIITFSFIIhQPWDD.KFMLIGLVLSLILLFLRQ............	0	0	1	1
+13164	PF13322	DUF4092		Domain of unknown function (DUF4092)	Mistry J, Aldam G	pcc	Pfam-B_2068 (release 24.0)	Family	This family is found in Proteobacteria. The function is not known.	22.20	22.20	23.40	69.80	21.00	20.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.00	0.71	-4.52	16	289	2010-09-06 16:06:56	2010-09-06 17:06:56	1	3	274	0	9	193	2	170.60	77	11.51	CHANGED	lAtpIDppLptp.sthspth.......hsshsssuuplpsslp+Lhsh..t.....a+sVspFHVFHDsosFYGuoGsARupsslNIoNpAFPVlMsRNDpNYWlsFGpppAWD+....suhAYIT...........................-APS........hlpP-+Vop-TATFNLPFlSlGclGcGKVMVMGNu+YNSlLsCPssYSaNGul	..............................................................Q.AKEIDTAICAK.TsGCNEARWFS....LTTRNVNDGQIQGVINKLWGVDss.....YKSVoKFHVFHDSTNFYGSTGNARGQAVVNISNAAFPILMARNDKNYWLAFGEKRAWDK....NELAYIT...........................EAPS........lVcP..ENVTRDTATFNLPFISLGQVG-GKLMVIGNPHYNSILRCPNGYSWNGGV.	0	2	4	7
+13165	PF13323	HPIH		N-terminal domain with HPIH motif	Mistry J, Aldam G	pcc	Pfam-B_2165 (release 24.0)	Family	This family is found in fungi on proteins carrying the PAS, Pfam:PF00989, domain. There is a well-conserved characteristic HPIH motif, but the function is not known.	20.30	20.30	22.40	30.70	18.80	18.60	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.02	0.71	-4.52	40	137	2010-09-07 08:27:00	2010-09-07 09:27:00	1	7	118	0	92	146	0	149.80	28	13.89	CHANGED	p+plTssLptlu+puCpHPIHTIllsALLASooYlull-sslhc...sspshstps..phsshltGu+sLhhGpsouW....cWphh-stsstsps..........spHhALhTLsFPco...ssssshPthcslshssNhStphLsposshhoshsp......-sulsaslPasps	..............+plotslttlu+huspHPIHTIVlsALLASsoYlull-tslh-....ssss..ssps.........chssh.ltGupslhhupsouW.....pWpshssppststs..........spHhALhTlsFscs...ssssssPthpsl.hssshothhLspo.sshhoshsp.......-sulsaplsasp....................................	1	13	44	76
+13166	PF13324	GCIP		Grap2 and cyclin-D-interacting	Mistry J, Aldam G	pcc	Pfam-B_2169 (release 24.0)	Family	GCIP, or Grap2 and cyclin-D-interacting protein, is found in eukaryotes, and in the protein Swiss:O95273, residues 149-190 constitute a helix-loop-helix domain, residues 190-240 an acidic region, and 240-261 a leucine zipper domain. GCIP interacts with full-length Grap2 protein and with the COOH-terminal unique and SH3 domains (designated QC domain) of Grap2. It is potentially involved in the regulation of cell differentiation and proliferation through Grap2 and cyclin D-mediated signalling pathways [1]. In mice, it is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumours. In vitro it acts as an inhibitory HLH protein, for example, blocking transcription of the HNF-4 promoter. In its function as a cyclin D1-binding protein it is able to reduce CDK4-mediated phosphorylation of the retinoblastoma protein and to inhibit E2F-mediated transcriptional activity [2]. GCIP has also been shown to have interact physically with Rad (Ras associated with diabetes), Rad being important in regulating cellular senescence [3].	21.40	21.40	21.40	21.40	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.82	0.70	-5.18	12	246	2010-09-07 13:57:06	2010-09-07 14:57:06	1	4	169	1	171	242	1	213.70	19	65.93	CHANGED	Wpclschu-pVS+pAThluhlW.pG.hPcs-shpcsh-saasuLpGhlLssHGpslGAGsTLppsl+sulKplVDuohpLhptsVS..h.tS.ppshcsslsplsGsVWEACsshc+lPpoNhsAIGpuhoplushlKDlLcEMcchh...............hhspupsstsssp.s-ss..s...spD..hS.E-hcVsp.shullppohsslKclIpsIsshh.......t-spshVspLEcLLclspclusplD-LGsSlY.PP.-hspl+tslp+ltuslcchhp.l	............................................................................................................................................................................................................................................................................................tt.p...t.......t..........sutlWt...sCpth....p.hs....p.p.sh.h.u.h.h.h.h.hp.p....hshlcDsh.cEhcph................................................................tpptp.....s.......t-p..p......t....t.s.......pD.................hp-.-..st.tlhp..sh..sllphsh...s...hlcpl....h........t....h.h.t.t..h......................t..p.......pps....s....p.L-cllshs.pcIssp..lD-lstolY...PPhs......lc.p..ttl.....................................................................................	0	50	78	117
+13167	PF13325	MCRS_N		N-terminal region of micro-spherule protein	Mistry J, Aldam G	pcc	Pfam-B_2099 (release 24.0)	Family	This domain is found in plants and higher eukaryotes, and is the N-terminal region of micro-spherule proteins which repress the transactivation activities of Nrf1 (p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1) [2]. In conjunction with DIPA the full-length protein acts as a transcription repressor [1]. The exact function of the region is not known.	22.60	22.60	22.70	22.70	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.22	0.71	-4.80	17	183	2010-09-07 13:59:08	2010-09-07 14:59:08	1	4	121	0	119	177	0	156.60	41	30.57	CHANGED	RWKPhDDLALItulpQTNDLchVHpG.lKFSC+FTLpElppRWauLLY-PslS+lAssAh+sLHPEsltulQs+ALaSptEEpLLuolpSsp.....pPsL-pFQ-LLccpssVFatuRTAKoLpsHWhLhKQYhLLPDQsVpPhtpsp.pslSFS....DAE-plsDs-Lp-scDE....uLEpELtlsDR+pKR-IRhLENELsRWsVLVD	....................+WpPtDDLhLlsuV.psssLptlahG...V+.FSp+FTlpElpcRWauLLYDPsl.....SphAstuMpp.............LcP-h..hs.u.lp..p+slaS.tEEplLtp.lts..sp.....................tsph.ppFpcLLp..ppspsFa.uRTspsL...sHW...hh+pah..LL...DQshtsh...tt...........shs....c.pt.h.p..................................................................................................................	0	38	58	94
+13168	PF13326	PSII_Pbs27		Photosystem II Pbs27	Mistry J	jm14	Jackhmmer:Q05RN1	Family	This family of proteins contains Pbs27, a highly conserved component of photosystem II.  Pbs27 is comprised of four helices arranged in a right handed up-down-up-down fold, with a less ordered region located at the N-terminus [1].	25.00	25.00	26.40	34.10	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.67	0.71	-4.21	61	146	2010-09-07 15:30:42	2010-09-07 16:30:42	1	2	100	3	77	153	105	141.20	29	87.46	CHANGED	hhpcll.......hulsL...sh......sl...h............lsus.............................t.ssss.slo...Gs.....YhcDThsVlpsLpssl..shs.....pDsss+pcstspA+chIs-alu+YRtpsplsu...................h..sSFsshp.oALNuLAGHYssaus+.PLPccl.+pRltpEhppAEpul	....................................................hhhhh.............hshhh....h.......h...h......h.ss....................................h.sssp.sho....Gc...........Yhp-ThsVlpsL+psl.shs.....p-ssshtcstspA+ptIs-alu+YRppsslsu.....................h..pSFsshp.oALNuLAGHYssaGs.p.PlPccl+pRlhpEhspAEtul.................................	0	22	53	70
+13169	PF13327	T3SS_LEE_assoc		Type III secretion system subunit	Mistry J, Aldam G	pcc	Pfam-B_2123 (release 24.0)	Family	This is a family of bacterial putative type III secretion apparatus proteins associated with the locus of enterocyte effacement (LEE).	25.00	25.00	47.40	47.00	22.80	22.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.80	0.71	-4.67	16	253	2010-09-08 13:46:21	2010-09-08 14:46:21	1	2	242	0	12	81	0	129.80	46	81.76	CHANGED	hhpLHpLsWpPupaAHPhWLssl.Glpsps.apYGcustLDssLsphLtphRsa.ppsLPssLsspQpp.lthttRlsshslALGLlpLpCsDYLhLppYRpsLtshLu-ssIpQLhGh.hhpGpp......sspL..sPppLsshAhplGpulhpphtsssslh+AlulhLPP	.............haphh..Ph.hhhs.WLstl.Ghp..s.hthtcp.thcp.LsthL.p.ht...phl.hs..sppth.ht.h.+l.hhshu.ulhtlpCsDYhhL.cYRQhLlphhu-s-IhQLhGa..hGtps.........tt.L..sPphhppsALplGsulL......sp.tpDsslhpAlhlLLPP..........	0	2	6	9
+13170	PF13328	HD_4		HD domain	Mistry J	jm14	Jackhmmer:Q05RX6	Family	HD domains are metal dependent phosphohydrolases.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-11.08	0.71	-4.50	118	7076	2012-10-01 20:28:14	2010-09-09 10:34:10	1	37	4412	2	1646	5095	2697	149.10	37	23.59	CHANGED	AhthApphat................tppttsGpshlsHslslAt..ll...tph....t...hD...ps.......sh..hAulLacss..........c..............-..........h.............pp............lp..cp....F...GspVApLVpuss.chtplpph..................ttp.......ptph-...slR+.hl...luh.....pD...h....RVl..Ll+LA-RlpslRth.......................tlApEshslausL.AsRLGlh	....................................................Ah.hAtptHp................sQhRp..S..G..-......P.Yl.h.HPlt.VAt.....IL....uch......p........hD........ts.................ol.hAA.LLH..D.ll...............E.................D.......................T......sss.....-c..........................lc..pp......F......Gpp......V.A...p.LV-GVo.Klsclpht..............................................spp...............ptpuE.....Nh.RK.MllAM.s.cD.l......RVl....llKLADRlHN.....M..RTL.....pth.....-...........KptclAcETh..-IYAPL.ApRLGl.t...........................................................................................................................	0	513	1040	1361
+13171	PF13329	ATG2_CAD		Autophagy-related protein 2 CAD motif	Mistry J, Aldam G	pcc	Pfam-B_2170 (release 24.0)	Family	The Atg2 protein, an integral membrane protein, is required for a range of functions including the regulation of autophagy in conjunction with the Atg1-Atg13 complex. Atg2 binds Atg9. The precise function of this region, with its characteristic highly conserved CAD sequence motif, is not known.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.02	0.71	-4.65	37	161	2010-09-13 10:50:17	2010-09-13 11:50:17	1	7	152	0	115	168	1	145.80	25	7.67	CHANGED	slslcDCslGLNPhphsuKsllllspuphsssh.tttpsphshpl+cuolhlIDDlps.t..........p..tp.ss.tssphps....hp.shGalslupIoosplslphtp.sppttpp............lDlcl+sDhlhLEsCADSTQTLIsllssLpPPs..Ps..ppKYR.T	...............................................................p.lthhDCslsLpPh.thsu+hllslsssphsssh..tp....sp...p.hphplccuslhlIDDsps......................tt.tstph.p.....hh.spGYVslsplushpls...lph.hpss..ppsppp............l-lclpsDllhLcTCADSspTLlsLlssLt.P...ss..t.Kap..................	1	27	56	95
+13172	PF13330	Mucin2_WxxW		Mucin-2 protein WxxW repeating region	Mistry J, Aldam G	pcc	Pfam-B_2205 (release 24.0)	Family	This family is repeating region found on mucins 2 and 5. The function is not known, but the repeat can be present in up to 32 copies, as in Swiss:C3Y5K5, from Branchiostoma floridae. The region carries a highly conserved WxxW sequence motif and also has at least six well conserved cysteine residues.	22.40	1.00	22.40	1.80	18.40	-999999.99	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.88	0.72	-3.55	91	678	2010-09-13 12:29:30	2010-09-13 13:29:30	1	101	53	0	385	687	1	85.80	34	12.24	CHANGED	tWTsWhstD.pP....s.ssG.DhEThss.lp..tt............hC....ptPs...s.IpCR..sh.........s.tpsGpt.lpCsh.ssGhh...ChNs.-Q..s.......ChDYEVRh.C.......C	.........................tWTpWhshchP........u.ssG..DhEohps.l+....tstp..........lC.........ppPhslcCRsps................sthsh.pp.hG.ps....lp..C.sh..shGLh...ChNc-Q.sth.......ChsYclRhhC..................................................	0	168	181	262
+13173	PF13331	DUF4093		Domain of unknown function (DUF4093)	Coggill P	pcc	Jackhmmer:Q7P4Q3	Family	This domain lies at the C-terminus of primase proteins carrying the TOPRIM, Pfam:PF01751, domain. The exact function of the domain is not known.	25.00	25.00	28.60	30.40	22.30	21.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.77	0.72	-3.78	141	1316	2010-09-13 13:16:25	2010-09-13 14:16:25	1	5	1303	0	153	724	4	86.40	42	46.33	CHANGED	slGVEpAos-sIpcALpclts...ppp..p.ppp.......................lohpDLhphGLhusssu+............pRRctLGchLsI.GYsNuKQLl+RLshatIocc-hppAlp	.....slGVEHAS.EsIccA.Ltplpp.....hc.p..t.pp........................IopsDLlchGLluGssu+............cRREhLGcpL+I.GYoNGKQLlKRLphFGlTps-lccAh......	0	59	102	128
+13174	PF13332	Fil_haemagg_2		Haemagluttinin repeat	Coggill P	pcc	Jackhmmer:Q7P6T3	Family	\N	22.00	15.60	22.20	15.60	21.90	15.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.39	0.71	-4.48	155	4185	2012-10-02 14:50:22	2010-09-13 16:16:57	1	347	516	0	992	4738	66	124.60	16	23.22	CHANGED	luhs..p..op....opsp...ppss.ss...su..Ssls.uG...ss...lslpAs.......p................uslsltGopl....pus...............s..ltLp.Asp.slsl.puup...ssppppsp.s.............p.SpususGluluhus.ss.......h.sh.su..ssutucu..p..ts..u..sus..shss.opl...s.uu.ss.ls.lpS....Gp..DoslpGAplsu..pplsssl.Gs.....s..LslpShQ..Do.......s..p..h....s..sp......s....tu..u	...............................................h...........tptp...tp.p.p..pt......u..oplp.us......ss.lslpAs......p..........................slsl.p.G..opl.....pu.s..............................................p.s.ls.....l.....t.A.....s.....p..sl.sl..tu.u..p....s..p...p..p..p....p....p...p..p.............................................p....p...t.............t......s.h.........t.............................................................................................................................................................................................................................................................tt..........................................................................	0	79	422	731
+13175	PF13333	rve_2		Integrase core domain	Coggill P	pcc	Jackhmmer:Q7P766	Family	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.76	0.72	-3.89	38	2406	2012-10-03 01:22:09	2010-09-13 16:55:03	1	11	1136	0	213	9884	987	54.10	42	39.33	CHANGED	EuFFGhLKsEhhasp..papohcchcpslp-YIpa.Y....NpcR....L....K....G....LoPlpYRspsL	...................EsFFGhLK.sEh....a....Y..ut......pa...p..o..h..c..p..L.c.p.s.I..h-.Y.I.c.Y.Y.....NpcR.................l....K...........G....LSP.lp.Y.Rpp..................................	0	41	116	163
+13176	PF13334	DUF4094		Domain of unknown function (DUF4094)	Mistry J, Aldam G	pcc	Pfam-B_2504 (release 24.0)	Family	This domain is found in plant proteins that often carry a galactosyltransferase domain, Pfam:PF01762, at their C-terminus.	24.50	23.80	24.50	24.30	24.40	23.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.32	0.72	-3.60	46	197	2010-09-13 16:05:43	2010-09-13 17:05:43	1	6	33	0	130	187	0	86.40	30	23.32	CHANGED	St+h.sllLChsSFhhGllhosRh...W...s....t..............tppppchplhpp-ssspp.......tpppclhtcVscT+psIp...sLDKoIosLEMELAuARup	.......t+h.shlLshhSFhhGhh.ho.sRh...W....s.t.............................pptppchpll....pp.s.sspcp................pppchht.pVscTp.csIt...sLDKslusLEMELAuA+u..........................	0	16	77	104
+13177	PF13335	Mg_chelatase_2		Magnesium chelatase, subunit ChlI	Coggill P	pcc	Jackhmmer:Q7P325	Family	This is a family of putative bacterial magnesium chelatase subunit ChlI proteins. The domain lacks the P-loop region present at the N-terminal of Mg_chelatase, Pfam:PF01078.	22.20	22.20	22.20	22.50	22.10	21.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.03	0.72	-3.59	197	3113	2012-10-05 12:31:09	2010-09-14 12:06:40	1	12	3054	0	770	2544	357	95.70	39	19.76	CHANGED	puEoSssl+.pRVhtARptQhpRhs.................ph.......Nupls......uptlc.ch.stLsppstphLcpulp+hsLShRuhcRlL+VARTlADLpuppplsppHluEALsYR	...........................t.uEoSssl+.pRVhtA.RchQhpRht.......................ch..............................NApls......upplc.p.a..C..t.LsspstphLcp...A...hp..+hsLSsRuacRlLKVARTIADLcs.s...-.......p....IsppHlsEAluYR........	0	270	528	664
+13178	PF13336	AcetylCoA_hyd_C		Acetyl-CoA hydrolase/transferase C-terminal domain	Coggill P	pcc	Jackhmmer:Q7P7G0	Domain	This family contains several enzymes which take part in pathways involving acetyl-CoA. Acetyl-CoA hydrolase EC:3.1.2.1 (Swiss:P32316) catalyses the formation of acetate from acetyl-CoA, CoA transferase (CAT1) EC:2.8.3.- (Swiss:P38946) produces succinyl-CoA, and acetate-CoA transferase EC:2.8.3.8 (Swiss:Q59323) utilises acyl-CoA and acetate to form acetyl-CoA.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.67	0.71	-4.55	251	2410	2012-10-04 00:26:15	2010-09-14 13:36:31	1	17	1795	21	696	2411	257	149.60	42	31.00	CHANGED	GopcLY-al.....-.....p.....NPplth.tsssasN.........s...PtlIu..ppsphluINoulclDLhGQVsu-sl.G.......s+..hhSGsGGQhDFl+GAthS..pG..G+oIlslsSTs..p........s...G....p....l.S+IVPhLs.GusVossRsclcalVTEaGlA.sL+G+ohpcRAcsLIs.IAHPcFR-pLhcpA	.................................................pchYc.h.....-p.....ps.cl.hh.RPt-hoN.........s..Pcl.Ip..+.hsl..lulNsulEhDlaGplNSspl..G.......s+hhsG.lGGpsDF.sRsAhh.........SIhsssSsA..c..............s...G....p.......I.SsIVPh....ls........pVspocpclcllVTE.Gl.A..D.LRGhosppRActlIs..hAHPcaRstLpch.h...............................................	0	268	472	621
+13179	PF13337	Lon_2		Putative ATP-dependent Lon protease	Mistry J	jm14	Jackhmmer:B8D5Z7	Family	This is a family of proteins that are annotated as ATP-dependent Lon proteases.	19.90	19.90	20.10	20.80	19.30	19.70	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.54	0.70	-6.13	53	313	2010-09-14 13:27:09	2010-09-14 14:27:09	1	3	292	0	83	269	74	438.10	48	68.76	CHANGED	sphF.sGhV.....VRKDLs+plKtuss.VPsYVLEaLLGpYCAosD-ppIcpGl.ppV+chLscpYV+scEuchl+S+l+EcGp.a+lID+lsV+Lsp+cDtY.AphsNLGl..c..clhIssphV+c.a-+LLsG.GlWsllslpYp...................hs-.................spcs.......sP..FhlpsL+PIQhsshD.hcphhpuRppFTp-EWlDlLlRSlGhEPss..hsc............RtKhhhLsRhlPhVEpNYNllELGPRGTGKSHlapElSPa.uhLlSGGpsTVApLFhN.ust...plGLVGhWDsVAFDEVuGl.pFc-.+Dsl.sIMKsYMASGSFuRGc..-..plsAsAShVFlGNls..psV-thl+su..H.LFsPhPpthp.Do...AFhDRlHsYlPGWElPKh..+s.-haTspaGhlsDY.LuEhh+phRc..ps..assslpcaFcl.GssLspRDppAV+KTlSGLlKLLaPs....GphocE-.lcchLchAlEsRRRVKEQL.K+luuhEFhcspFSY	.............................................ptF.sGpVVRK.D.L..s+..p..lK.tGA.N.VPsYVLEYLLGhYCuo-D-phIppGlpsVKcILu-sYVRP-EAptl+Sp.l.R.EcGp.a+lIDKloV+LspKcDhY......AphsNLGl..p....ss.lssphV+c...-.+LLsG..GIWsllslpY.....................hc.c..........................................spps.......sP.F.lpsL+P.IQhs.s.hD.h-c.lhpu.RppFop-EW..lDlLlRSlGhE.Psp..h..sp............RsKhhlLsRhlPh.....V.....E...sN....YNlsELGPRGTGKSHl.Y+EhSPp.ulLlSGGQsTVAsLF....YNhus+...plGLVGhWDsVAFDEVAGI..p....FK.D....KDuV...pIMKDYMASGSFuRG+....-.....plpupASMVFVGN.IN..po......V-.s...llKTS...............+LhsPhPpthh..D.o...AFhDRhHsYlPGWElPKh..+P..EaFTspYGhloDY.LAEhhRc.hR+....p.s....a..uDsl-caFcL...Gss......LspRDshAV++TVSGLlKL..LaPs........GpaoKE-.lc.phLphAlEhRRRVKEQL.K+lGGhEFa-lpFSY.........................................	0	38	63	75
+13180	PF13338	DUF4095		Domain of unknown function (DUF4095)	Coggill P	pcc	Jackhmmer:C2D0I5	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.64	0.71	-3.98	231	2088	2012-10-04 14:01:12	2010-09-14 16:14:53	1	8	1014	0	614	1837	131	118.00	17	48.01	CHANGED	Gl.......s.....htlp..chh.cpGplp+lp+GlYh...........h.......sst..................hcp.........hh........hh.stt......h..............s.pu.....l.lu.htoALhhau..l..s.s..p.hP.t.thpls...sspstp...t.php.......tlphhth.p.tphhp..h.Ghpphph....stsltlhshERTlsDhh	................................................tlpchh..ppG.t.l.+l...t.+..G...lYh.............h.ssh...................................hcp.........hh...........hh.ttt..h..............................s.pu......l.l..u..t.t.oA....h.th...aG....l.......s.s....p.hs.....t...th.......p.lh....ssp.stp..................s..tht..................slph.hhh..p.....tphh..........t.h.....t.....h............sl.lhs.t+ThhDh......................................................................	0	204	424	536
+13181	PF13339	AATF-Che1		Apoptosis antagonizing transcription factor	Mistry J, Aldam G	pcc	Pfam-B_2199 (release 24.0)	Family	The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.	24.70	24.70	25.70	25.80	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.99	0.71	-4.00	65	310	2010-09-14 15:30:23	2010-09-14 16:30:23	1	4	266	0	215	308	2	134.70	26	27.10	CHANGED	DstKGh..AVcpQpphaDplL-sRI+LQKulssuNpLP.ptpshp.h..................tspptppslpssppsshpLhsslhsL+psLh................................tttp.spstpppKR............t.shschhpphpp....hcpphpsaRsslLpKWupK	.................................................................-spKGt..AV+pQhtlaDplL-hRI+LQKulsssNpLP..pspshs.h.........................ttspphppslcsspcsht..pLhps.Lh..sLpppLh.............................................................tttpttpttpppKR....................p.phshp.ch.pthsp....hppphpsaRspsLpKWppK..............................................................................................	0	68	115	176
+13182	PF13340	DUF4096		Putative transposase of IS4/5 family (DUF4096)	Coggill P	pcc	Jackhmmer:C2D5Z9	Family	\N	21.90	21.90	21.90	22.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.52	0.72	-4.12	381	3268	2010-09-14 15:35:10	2010-09-14 16:35:10	1	25	878	0	1120	3161	331	69.30	31	41.37	CHANGED	LoDppWshlpPlL...Ps..........tp....t.tt..........t..phspRpllsuIlalh+oGssWRsLP.pc..au..sap..TlappFpcWpcsGlapc.lh..p	........................loDtpWth.lpshl....Pt..........tp....t.t...........t..thctRtlls...ull.a....l.h....+o.Gst..WR.................t.LP..pc......au.....sap.....TlappFpc...WpctGsapplh.............................	0	323	715	905
+13183	PF13341	RAG2_PHD		RAG2 PHD domain	Bateman A	agb	Bateman A	Domain	This domain is found at the C-terminus of the RAG2 protein. The structure of this domain has been shown bound to histone H3 trimethylated at lysine 4 (H3K4me3) [1].	27.00	27.00	27.10	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.97	0.72	-4.00	6	1007	2012-10-03 17:27:21	2010-09-14 16:38:22	1	3	816	14	26	965	0	55.10	80	13.56	CHANGED	GYWIKCChuCpVD.NTWEPaYSTELs+PAMIaCS+G.uGHWVHAQCM-LoEohLlpLSQuNsKYFC.-HstLs+t..TP	.GYWIpCCsTCpVDlNTW.PFYSTELs+PAMIaCS+G..sGHWVHAQCM-L................................	0	1	3	10
+13184	PF13342	Toprim_Crpt		C-terminal repeat of topoisomerase	Coggill P	pcc	Jackhmmer:C2D5X4	Domain	\N	43.70	43.70	43.80	43.80	43.30	43.60	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.40	0.72	-8.88	0.72	-4.34	157	1275	2012-10-03 10:42:43	2010-09-15 11:56:09	1	20	649	0	258	1109	139	62.40	33	11.70	CHANGED	psCsFplh+p.lsu+plopsplccLLppG+Ts.llcGFpS.KsG+pFsAhL.hlpts...pp............lsF-.Fsp	.......sCcFplh+p.lsu+plopsplccLL...ppu+Ts.ll+GF+S.K.sG+.sFcAhLhhpsc...tp............lsFpFt.........	0	74	171	216
+13185	PF13343	SBP_bac_6		Bacterial extracellular solute-binding protein	Bateman A	agb	Jackhmmer:Q7P755	Family	This family includes bacterial extracellular solute-binding proteins.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.57	0.70	-5.05	82	6234	2012-10-03 15:33:52	2010-09-15 13:11:13	1	13	2738	20	1426	11548	3747	237.10	19	69.13	CHANGED	sphsDllhu......hspthhpphhppshhp..............ssthsphst......tshtDs.cGtah..hhshsshlhhhsppplssp.h....P..psWsDLh.sPpacs..plslssss........shhpslhlslhp......phG.hcsstchhcshttsh+ssp...hschhsphpssp..........lslhshahsphhtppp.........shpllhPc-.GuhlsPhhhhlpps......ptctspthlcahhusc.htphhupsth.........hPs...........hpsshtsph.pstthphlsW-alppp	.....................................................................................................................................................................ADllhs....................hsss.h.t.th..t.p..p.u.l.h.t.s.hp.............................................st.t.h...s...p...l...s......................tthp..cs...p.....s..p..ah.............sh..s.......h.t....s.h....u....h..hh...N....p....c....t....l....p....p..........h.......P...........ps...a......p......D...L........h......c........s......c.........a.......+..s........c.....ls.hs.ssts..............tssshsh.l..tshhp.............................................................thG..tc...t...u..h...p...a...h.p....p....L...t......t....s..h......s.phs..........tsss.sh.p.t..h..t.pG-.................hs..l.s..h...s...a....h...h...s...h..h..t.t...ppps................sl.p.h...h....h......P.......p..........p....G.........s.....h.....h.....p.....s.......p......s.....s...ul..h+s...............upp......ct..A.cpa.l.-ahl...S.sc..sQ.p.h..h.spssh...........hPst....................t............................................th....................................................................................................................................................	0	374	805	1139
+13186	PF13344	Hydrolase_6		Haloacid dehalogenase-like hydrolase	Bateman A	agb	Jackhmmer:Q7P3Y5	Domain	This family is part of the HAD superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.11	0.72	-4.12	179	4798	2012-10-03 04:19:28	2010-09-15 14:26:07	1	25	3106	27	1565	3385	1469	102.30	28	34.77	CHANGED	hlhDhDGVLa....................p.......Gsp..s..lPGAs-slptLcpp.G........................hphhhlTNs..us+otpphtpcL..pp.l...G.ls.....h........s.t.c.....pllsSupsstphLpp..........t..............................spplhllGs..p.....s..htptlcphGhp	....................................................................................hlhD.lDG....sla.........................................................................c.........G.sp....s..lP.u.A.tchlc.t..Lppp.s........................hshlalTNs....ss+o.psls.p+L...pp.h...G.ls........s.................st..c......plhTSuhAss..c....alpc.............t...............................spp..l..allGp..t......u..ltptlpphGh.............................................................................................................................................	0	484	900	1295
+13187	PF13345	DUF4098		Domain of unknown function (DUF4098)	Coggill P	pcc	Jackhmmer:C2D3F5	Domain	This domain is a C-terminal repeat found in many bacterial species.	24.40	7.80	24.40	7.80	24.30	7.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.39	0.72	-4.03	289	4531	2012-10-03 02:33:51	2010-09-15 14:57:46	1	38	1424	0	1491	5507	345	72.60	17	44.79	CHANGED	shp..s.s..pl..plps.s..sG.s.lpl..p.s..l...pup....l.pl.p.ss..s..G.cl.plp..ss.pu.....shphpsssG.c.lp...l..p...s......phs...slph..p...s.s..sG.s.lp..ls	.....................................................................................t.......hphps.s.sG..s..lpl.....p...p...h......psp........h..pl..p..os...s...G..sl...plp.....ss.ps.............slp.l.p..o...ss.G..c...lp.........l....p................t..................tht.........php.h...p...s.....sG.pl...t................................................................................................................................................	0	607	1005	1297
+13188	PF13346	ABC2_membrane_5		ABC-2 family transporter protein	Coggill P	pcc	Jackhmmer:C2CY30	Family	This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.78	0.70	-5.03	126	1444	2012-10-03 10:13:34	2010-09-15 15:17:57	1	3	724	0	151	2276	340	201.80	18	90.65	CHANGED	uLllKDhh...hh+p....h..hhlh..hh.lh.hlhhhh.hh.....ptth...hh...hshh.shhhs..hhhh..h......ss......hp..hDc.p...sch...sthlhoLPlsRcplVhuKYlhsllhh....hluhll.sh.lh.......s.h.l...h..h...htts.....hsh..t.hhhh..h.hhshh..hs....hlh....hulhlPlhacaG.c+up.h.......lhhhhhh...s.......lh..h.....hhh...th...hp...h..........p..tl..........hht...hhshss...h.....hl.hh...hhhhl.h.lh...hhhlShhlSlpIap	..........................................................................Lhhpshh....hh+t.......h...hhl..h..hh..l.h..shhhhhh...................s...h......hh...........hs.h..h....ss...h..hh.....h.hh..h....h...........ps..........hp...h-c.c.........sch...thhlhoLP.ls..Rcpllh..u+..Yl.....h...sllhh....hh..u..h...l.l.s.h..lh...........................s..h..........h...l........lpss......................h..h........h.h.h.......s.....h.h..h.hh....h.h....hhh.....hu.l..h.....hP..h.....h.a....t....h..u.h...cps.p.h...........lhhhhhh..h.......................lh...h.............hhh....sl....ht...h...........................p..th...............................hp...hhsh.s.....h..........ll.hh...hh.hhl..s.ll...hhhlShhlSlpla............................................................................................................................	0	67	117	132
+13189	PF13347	MFS_2		MFS/sugar transport protein	Bateman A	agb	Jackhmmer:Q7P3E5	Family	This family is part of the major facilitator superfamily of membrane transport proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.27	0.70	-6.08	92	6648	2012-10-03 03:33:39	2010-09-15 15:21:27	1	29	2127	0	1465	15146	4138	393.70	22	86.65	CHANGED	p+ls.YuhG...s.hupshhhs....hhsh.alhhFaTDlh..Glss.......uhluslhhlsRlhDAltDPhhGhlsD...pop..o+aG.+a+PWllhuulshulshhlhF.........................................................................................s.P.shshss...........phha......................................h...hlsYhlh.slhYohh..slPahuhssslopcsc..-RsplsshRthhusl.us.hlssslhhsll..........shhussst.................................................................................................................................................................Gahhhshlhulluhl..hhhhshhss+E....................................tpppphshtphhcslhpNc.hhhlhhhhlh..hhhshsltsuhhhYahpYslsss...s...hhshhhh........hhhlssllusslh.sh.lsc+h...u++p.hhhhuhhlhhlshhlhhhhs...........sshhhhhshhslhshshshhh.hlhhshlsDsl-Yuph+..sGpRtpulhhuhhshhtKhuhAlusslsuhhL.shsGasuss.........s..posssltslphhhshlPslhhlluh.lhhhhYpLsc	...............................................................................................................................t..hh.YuhG......s..hutshh.hs..h.hhh..al..hh...a...Y.......T...c..l.h............G..l..ss.....................................shsGh....l.h....l..ls.+l...hD.A..l.s....D....P.h.h....GhlsD...............psp.......o+..a.....G..........+...h..R.P..........a..............l..L..h..u....s.....l.....s....h.u..l...h..h.h...l..h.F.........................................................................................................................................................................................................................................................................................................h.s.....s.......t..h.s.h.ss..........................p.hla....................................................................................................................................................s..........hlsah.l.h.....sl..ha.o..h.h.....sl..P..a.t....u....h....h..s..s..l...T...p......s.....s.p......c..R..s..p..l...s...u....a...R....h..h....h......u.....s..l...us....h...l..s.s.h.h.h...h.s..lh......................shh..u..s..s...p..t........................................................................................................................................................................u.a..h...h...h...s..h....l..h...u..l..h..u..h...l....h...h..h..h....s...h...h..s..s..+E.......................................................................t...t....t.....p.....p.......h.......s..........h........t.......p........t.......h......p.......t........l........h..........p..........N..........c.........h.........h.....h.......l........h....h....h........h....l...h......h..h......h.........u.....h...s.....l....h...s....u....h...........h..........h.........Y......a......h....p......a....h.....l..s...ps...............t.........h....h....s....h.h..hh...............................................................h.h..h....h....s.....s....l....l.....u...s....h...h...h......sh....l...s.c...p.h...............u+...p.....p....h.......h.....h....h....u....h...h....l...h...s...h.....s.....h.....h..h..h..h.hs...............................tsh.h..h....h...h....h.....h...h....h....l....h......s.....h....s.....t..........u.....h....h.............s......l.........h...s.h...h.....u.D...........s....l.-.as.......c.....hp.............s.G.....h..........R.......h...p...G.hha...u..h.h..s.h...h.h...K....hu..u.lu.s.h..h......h.u...hh..L.....sh.....h..G....Y.ss...............................s....Q.ss..t..s..l.s..lh.h.h....h....hh....h....P.s.hhh..hlsh..hhh.hh.a.lp.................................................................................................................................................................................................	0	457	814	1153
+13190	PF13348	Y_phosphatase3C		Tyrosine phosphatase family C-terminal region	Coggill P	pcc	Jackhmmer:C2D3Y7	Domain	\N	22.00	22.00	22.10	22.30	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.15	0.72	-3.86	223	1604	2010-09-15 14:47:59	2010-09-15 15:47:59	1	18	1059	3	505	1321	176	65.90	20	23.01	CHANGED	ph..hpph.tt.tstspthhp....h.....hhss...p..tp.al.pssh.stlcppaGuhcsYLppslGlsspplppLRpphL	.........................................tht.................ht....hts.....hhss....c...tc.alpssh.ptlcppY.G..uh-sYLpcslGloppplpp.L+phhL............	0	153	323	426
+13191	PF13349	DUF4097		Domain of unknown function (DUF4097)	Coggill P	pcc	Jackhmmer:C2D3F5	Family	\N	23.00	22.60	23.00	22.60	22.90	22.50	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-11.41	0.71	-4.70	53	1584	2012-10-03 02:33:51	2010-09-15 17:17:30	1	18	1137	0	191	1342	30	157.20	17	50.57	CHANGED	KKh.lhhuhslh...ll.....Gsll.hhh.u..htssu......h.a...spt..pltp..................ppph...cslsplsl.psss.sslpIpp.ussppl..pl..ph........ppp..........hpl........ptss.spLpl.ppp.tpp.hhhh.......shsht......t..tpsplplplPcsh....phs....slplps.s..Gsls...lp.s..l.phc.sl..p.ls.s.su...slphp	..........................................................................hhhh...lh.....uhhh..hhh...s...h...s..................................h.p....................................phsht...pshc..plpl..s............hss...t............s..lplpp..us.s.p...pl..cl..ph.................psp.................lph.................p.s.s..psLpl..ssc....tt...hh....................................hhphts.................tpppl......sltlPcph.........................lc...................plslps....s.......sGslp........lps...l..shc..sh..s.lp.s.ps..G.pl.......................................................................	0	72	121	154
+13192	PF13350	Y_phosphatase3		Tyrosine phosphatase family	Coggill P	pcc	Jackhmmer:C2D3Y7	Family	This family is closely related to the Pfam:PF00102 and Pfam:PF00782 families.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.13	0.71	-3.99	403	1860	2012-10-02 20:12:17	2010-09-15 17:39:40	1	30	1165	3	645	2255	428	158.20	28	56.25	CHANGED	NhRDlGG............a...st............sGp...pl+hGhlaRSusLspl..o.s....s.DhphLt..slGlppllDLRsstEhppp....P.........c.hhh....s......usp.h.hpl..slh..sss.s.s...........................tt..h.t...thht.t...............t...t...stphhtch..Ypphlps....t..tss....appl..hchlts....s.s...s...slLaHCoAGKDRTGlsuALlLthLGV.sc.-s.IhpDYlloN	......................................................................................................................................................NhRDlGG....................................h...st......................sGp..pl+.shlaRSu.p.L...s.p.l....o.p....t.Dh.t.hL....t...p.....hsl.ptlh...DhRo..s.tEhptt......P.................................s.....h..t........ss.p.h.hth..s..lh..stttt..................................................t..h.t...t.htt...............tt.s.phhhphY.p...p.h.lpst.........pps....apph..hp..h.lhs.................ss....s.....sllhHCo.............AGKDRT..Ghs.u.A.L.l.L.t.h.L.....G......V.sc..cs.Ih...pDYlhop.......................................................................................	1	218	425	550
+13193	PF13351	DUF4099		Protein of unknown function (DUF4099)	Ellrott K	pcc	JCSG - Joint Center for Structural Genomics	Family	A family of uncharacterized proteins found by clustering human gut metagenomic sequences [1]. The C-terminal repeat region of this family is DUF4098, Pfam:PF13345.	22.00	22.00	22.50	25.60	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.61	0.72	-4.09	51	427	2010-09-15 16:54:58	2010-09-15 17:54:58	1	5	128	0	40	345	4	84.10	31	20.97	CHANGED	ap.pclsWcpLc.phGlo+EpLEp.stp.L-plLpGt+os.llslphshsss.tl.ph-A+LulhpspsG.plsltlaslpp.pspL-p.hh	.....hc.sclsWppLc.phGlo+-p.LEp.ssp.L-phLpGtKos.llslp.hshsst.sh.ph-ARLuhhpss-G.plslshHslRc.c.pL-t...........................	0	13	35	40
+13194	PF13352	DUF4100		Protein of unknown function (DUF4100)	Mistry J	jm14	Jackhmmer:Q05Y37	Family	This is a family of uncharacterised proteins found in Physcomitrella.	21.40	21.40	21.70	21.40	21.20	21.30	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.37	0.70	-4.89	15	2840	2010-09-16 09:21:40	2010-09-16 10:21:40	1	6	1	0	2840	2906	0	132.50	52	29.62	CHANGED	AYIAKSQHEALMEEKRRGNFDDTREGNSSKRQTRGDKAREAASQELPVKDTSsSLtEKTKETKDKGKSIAYKLLSDIEAATNLKGVLEE+ILNAKlEFtLKElLtIsKKEFHDVIIDSIK+KRQLMuEstMsHAIDARIY+DEEEV.D.sYKQsTNEKNuYNQRVRFED.SDKEhEshSHYTRKHWARsTTEVLVKVGDIEEPIVALVDHGSE	..............................................................................................................................................................................................................................................................................................................................................................................................................................................h.....t...hpssh.shKt..........hL-.Ep...l....Lss.KlEFhl+-hLt..IsK.+-.....Fa-lI....I..ssIK...p.Kp.................................l.h......c-.E.E.E....l...s.........h......t...p...........h.........p....p...................t...............................................................................................................hhhc............................................................................................	1	2840	2840	2840
+13195	PF13353	Fer4_12		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:C2CYL4	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.03	0.71	-4.06	147	15922	2012-10-03 08:56:43	2010-09-16 11:21:53	1	90	4368	5	3584	16094	3629	134.80	18	43.59	CHANGED	lNGsG...s...R...s.....oLa..VSG..Cp..+..pCc..G..C...aN...pssW............shs....................tGp.a...s.....pchpcpIlppLp...s....shl......pGLol.GGEPhh....Nt..p..sllpLl.++l+pch...s...sKsIWhaTGYph-.cLt......p....p.........ppclLshlD...V.LVDGcFh.psht.D.....s..Lt.aRGSuNQ+lh	................................................................................h.h....h.p...s...Cs..h...........cCt.a......C............h.s.........p..s..h..............................................p..h..p........................................................................t.s..p.....h.........o.........p-h...h.......c..p....l...l...p..t.h.t.........p..........tth..............ts.l.s...l...o....G....G...E.....P.h..l.......th.......p...hl.h..c....l.h....p....t....h....+....p.ps...............h............p.........h....h......h....p...s....s.G...h....h....h.t..p.h...................................h.th....h....p........h...s........h........l....D...h..................................................h...........................................................................	0	1305	2427	3058
+13196	PF13354	Beta-lactamase2		Beta-lactamase enzyme family	Coggill P	pcc	Jackhmmer:C2D5A8	Family	This family is closely related to Beta-lactamase, Pfam:PF00144, the serine beta-lactamase-like superfamily, which contains the distantly related Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.14	0.71	-4.87	138	5244	2012-10-02 21:13:33	2010-09-16 14:09:41	1	27	2386	268	694	10619	1975	200.40	28	66.42	CHANGED	lss..sp...hh...sh...sscph.hssASshK....l....s....l....h..........ptlp....p.....Gcls....Lsc.....plphp.p..pp.......h..s..s..Gu.....Ghhp.hh..s..s.s..p..holp-LhphMlshSDNsAoNhLlchl....G.hps...lsphhpp.hGhps.stlpph......h.........................................................shp...t.....t...p..N.....to..osp-hspllp....tlhp....s..............p..h.ls................hp.......h........l.p.p.....pth.....p.p.t.ls...ts.l.s..............ps...h...p.lu...pKoGs.......l.ss.....hppD...sGll.hh..ssps.allul	...................................................................................ssp..h...sh...ps.c.c+.ash.sSThKlh....l.s........................ttl...........t...........s.p...p....Lsp.....p.l.p..hp....p...s-........................l...s...p......ho.......s..l.hc.....+t....h.....ss...s...h...olt-..L..s..p.u..s..lphS.....D.N.....s.A..s.....N.h.....L....l.p.....pl.............G.Gs......p....t...................l..s....s...h.......h.......+.......p.......h...G...s.......p..s...s..p...lc+h.......cs............................................................................................................phs....ths....s...st...c...c...............oooPtu.hup.s.Lc....pl.ht.....s....................................p..h.Ls.tpp.......................t.lhp...h......................ht....s............s.ps......s...t..h.....lp....us.lP...........................................tsh...h....l.u..c.Ko.Gs..................t.hs.......s.ps.p......luhlhs..stts..hhls......................................................................................................................................................................	0	200	452	595
+13197	PF13355	DUF4101		Protein of unknown function (DUF4101)	Mistry J	jm14	Jackhmmer:Q05S35	Family	This is a family of uncharacterised proteins, and is sometimes found in combination with Pfam:PF00226.	22.80	22.80	22.80	22.80	22.20	22.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.43	0.71	-3.69	63	153	2010-09-16 15:48:57	2010-09-16 16:48:57	1	4	101	0	70	172	95	115.10	26	17.52	CHANGED	AppllppWLssKupshussas.hs.....tLppllssshlsp.hpppsp.........thpppstahpa..hphplpulph.sps...sppst...lcAplpEpsphhs.sGphpsp.ohsssh.pV+Y.Ls+p.ssp.W+Ips	............AppllppW.ssKupAhGssap.hs......tLpplLssshLpp....hppput....................thpppshaapat.hplplpslph.sss....sppAt.lcAplpEssplhs..sup.ppt.ohpssh...pl+YpLt+p....sst.W+Ip..................	0	14	49	65
+13198	PF13356	DUF4102		Domain of unknown function (DUF4102)	Bateman A	agb	Jackhmmer:B3CUZ6	Domain	This presumed domain is found at the N-terminus of a wide variety of phage integrase proteins.	27.00	27.00	27.10	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-10.12	0.72	-4.10	255	5922	2010-09-17 08:49:24	2010-09-17 09:49:24	1	16	1625	5	949	4352	701	86.60	34	23.48	CHANGED	LT.cptlc.........sh..psps........pp.......htht..D.......t.........GLh.lpVp.s.s...G...sK..sah.hcY................ths..G+..pp......p...h.sl..Gpa....Ps..................l......oLspARppspchpthl.s.p.GhD..P.ttp....+cppct	.....................Loctplcsh....KPpc........K......hpls.....D.....G.........tGLh..Lh.Vp....s...s............G.......s+...hWp..h+Y.................+hs....GK........pc........p...l..ul..G.sY.......Pp.....................l......oL...u.-ARppt.p.c.h+phl.u.p..Gh.D...Ptpp+pttp.h.............................................................................................	0	174	512	736
+13200	PF13358	DDE_3		DDE superfamily endonuclease	Bateman A	agb	Jackhmmer:B3CQR6	Domain	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.93	0.71	-4.45	69	7080	2012-10-03 01:22:09	2010-09-18 09:34:17	1	125	1242	0	3290	6631	624	121.10	21	54.12	CHANGED	pllahDE.sshphph.thttuas.pGpp...h.htstt+tp......phshluA.lshps...hhsh.hhh.......................................ps.shsuptaht.alcphltshhp.................thhllhDNss..hH+u........ptlpph..........lps...............................sshplhaL.....PsYSP-LNPIE.thWuhlKppltp..tthpshcslp	.........................................................................................................................................................................................................................................................t...............h....hhus...hp.....tt......h......h.h......................................................................................................................................................................................tt...thst..t...h.....t...hl.p..p.h...h..........h..p..................................thhllh...D.Nss..............hHps....................................pt.lp.p.h................hpp..................................................................................................................................tp...h.p.....l.h.h.h.......P.s.a.S.P.-.L.N.P.IE..phWth.l.+.p.phhp.............h..................................................................................................................................................	0	1274	2326	3074
+13201	PF13359	DDE_Tnp_4	DDE_4;	DDE superfamily endonuclease	Bateman A	agb	Jackhmmer:B3CSL4	Domain	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.86	0.71	-4.63	61	3886	2012-10-03 01:22:09	2010-09-18 10:01:42	1	51	549	0	1579	4471	221	120.50	28	53.91	CHANGED	lDsocl.l..ppPp...s........pstsasthKppp........olphhl..sssssGhlhh.lstuasGpssDpplhppS.shhph.......................ss.chlluDpuFs..hpp.........h.hshpt...........tttpl.sspc..tphNpplu.phRhhVERshshlK.paphL...pptlthp.............hpphsclltssssLpN	...............................................................................................................................................................hph.h....h........s.s...p..hp.hh....h.h.....h.....s...........h......pDh..p..l..h.p.......u......h................................................................s..hh.hluD.u..GYt.....sh...........tl..................sPh+t..........................................................phps......L......sspc......cthNct..l.u....p......t.............RthlEp.hhup....lK...pa+hh.....ppthc.p.....................hpphsh.h.h..h.hsslhN.............................................................................	0	715	1056	1438
+13202	PF13360	PQQ_2		PQQ-like domain	Bateman A	agb	Jackhmmer:B3CRY3	Domain	This domain contains several repeats of the PQQ repeat.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-12.25	0.70	-4.91	112	7855	2012-10-05 17:30:43	2010-09-18 13:57:24	1	358	2271	34	2581	8458	4130	182.50	15	45.19	CHANGED	spupl.tuls...t....sGpplWpt.....sh.t...........................................s.............huuGl..sh.sssplhls...s.......stuplhulcsssGphlWpppl..suthhus.....................P.hlssspl.....hlhs...........sDs..plhu.....ls.spsGch.......................hWp.hpts.......s.sshs..ltussssshs....sshl.....lsshs.....uGcl...........hulshpsGph..hWptsl.utsp.............tssphp....plsDlsusPlls....ss...plhssuhpG....p...h.....ssh.-htsGp....hh.W.sps.huu................hps.shsssshlahss.p...................p....uplhslctpsGphhWpp	..........................................................................................................................................................................................................t..................................hWt............th....................................................................................ts.h.......s.h........s..s...h...l...a...hs...........s....................tp.s..t.l.h..A..l...c..s.....t...s....G......c......h....h.....W..p.h...ph......ss.t.h..tss...........................................................P...s..h....s...s...s...tl......................hlss......................................tsu..........pl.hA...............l.....s....tts..G.ph..........................................................................................................hWp......................................................t........h.........s....hh......................tthh......................h.h.s.................................ss....l..........................................sh...t....t.....p...G..p........hh...t.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	857	1659	2192
+13203	PF13361	UvrD_C		UvrD-like helicase C-terminal domain	Bateman A	agb	Bateman A	Domain	This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null --hand HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.30	0.70	-4.99	35	17009	2012-10-05 12:31:09	2010-09-18 16:32:58	1	133	4760	29	3900	14321	6091	300.30	21	37.70	CHANGED	lpLEpNYRSstsILpsANplI.............................ppsppchpK...tLhsspssu.pplphhpspscpc........EAchl...spcItp...............htpp....shp.hpDhAlLhRs.NtpucslEcsLhpts.IP......Y.clsGshpFa-RtEI+DlLuhL+.llsNspDc.............hulhRllssPt.+G....IGssolppltp..hspppplshhphh.............................................................................................................................................................................................hh.ttlstcstptlpsFhphl........................pphp.p..ht...hshpphlcpllcctsh.hphlppt.....cpucp+lpNl..pcL..hshhcca..............pp.t.................p.tsLhsFlpchsLpsptpcpp.......tpt....st.VpLMTlHuuKGLEFPhVFlsGh....pcu............................................hhP.............................ptpuh..tptcplp...EERRLhYVulTRAccpLalotspp	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LppNaRSp..tllphs.s......lh..........................................................................................t..t......t....................t............h...h..................t....t...t.....t.................t..........h............h.....h..............h........s....t...t......................................c...s....p..h...l.......st...p..l.p................................................................................h.tt.........tht..hp-....h..AlL...h.....R....s.....p.....t.........p........s...t..................h...p....p....h..h....h....p.....t.....l..P...............h...hh...s..t.......p..h..h..p..p.......p.l.p.t.h.......h.s.h....L.p.....h.l..........s..............p...p................................s.h........t.h..l.t..........sh.....h.......t.......h..s.........t.p....h..t..l.......................................................................................................................................................................................................................................................................................................................................................................................t..........................h......t..h....h...t...h.h.....................................................................................t...th...t...............................h...h....t...t....h....h..........p.......t..............t....h........p...h.h.tt.......................tst.t.ph..t..s....l......tth.........hp.h.h.p.ph.......................................................t....................................................................................t........t....l..........t...h...l...p.....p......h....t......h........t..tt....ptt................................tt......................st..V....p.......l...h.......Tl........Hsu...KG..LEa.s..h..V.....a.l....s..s.....h.......pc...s..........................................................................h..hP.....................................................................................................................................................................................................................t.t.sh............p.tpp..l..p..........E..E.....p......R....LhYVulTRAccp.Lhlsh...t...........................................................................................................................................................................................................................................................................................................................................................................................................	0	1318	2605	3363
+13204	PF13362	Toprim_3		Toprim domain	Bateman A	agb	Jackhmmer:B3CQ99	Domain	The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation [1].	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.30	0.72	-3.75	51	1268	2012-10-01 21:47:57	2010-09-18 17:02:44	1	39	840	0	288	2429	926	98.00	25	17.03	CHANGED	hlhlsEGlEouLSl....htshsshsshAshus..sslp......slths..t.thccl..hlstD.sDss...........GppAstcl........sc+hps.tuhpstlltP........pu........DaND..slpptGtc	..........................................lhluEGhtTALol................thhss.h.ss....h....A...s.h.su......s.p.Lp.....................................sl.ths.......t..ss..p..pl.........lIs.u.D.sDhs.t...............................Gpp..su.pph.....................s.pt...h...t...t.........s.....h..t..sh..h..l.P.................shs..................DaND...hhpt.G.............................................................	0	65	161	226
+13205	PF13363	BetaGal_dom3		Beta-galactosidase, domain 3	Bateman A	agb	Jackhmmer:Q700S9	Domain	This is the second domain of the five-domain beta-galactosidase enzyme that altogether catalyses the hydrolysis of beta(1-3) and beta(1-4) galactosyl bonds in oligosaccharides as well as the inverse reaction of enzymatic condensation and trans-glycosylation. This domain has an Ig-like fold [1].	27.00	27.00	28.80	29.80	25.70	26.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.52	0.72	-4.59	56	193	2010-09-18 17:35:32	2010-09-18 18:35:32	1	10	99	6	137	210	0	80.10	32	8.04	CHANGED	WsPsl.ssss.s.......sp.sllVpGsYLVRoAslp....G..ssLpLsGDhsso.TslEVaus.p.slpslpWNGcclpsspos.hGslpu	...................Wss.h...spss.s.............sp.sllVpGsYLVRoAslp......GssLpL....pGDhsso.....TslEVh..........us..p..slpslpaNGcplptp.psp..Gshh............	0	39	74	112
+13206	PF13364	BetaGal_dom4_5		Beta-galactosidase jelly roll domain	Bateman A	agb	Bateman A	Domain	This domain is found in beta galactosidase enzymes.  It has a jelly roll fold [1].	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.92	0.72	-3.80	105	562	2012-10-03 19:46:52	2010-09-18 22:23:13	1	26	198	12	334	675	18	112.50	22	20.36	CHANGED	Ys-p..uW..ssss..sos.........s...sss.........hsu...hpsGsthYRspF......p....h-..hu....hp.............stsusuat.........splalNGh.hGp.as......shusp........ssaslPp....slLsh.....p........stlhsslhspsuts	................................................................as-p..sW...........sshs..sst...............ttss.........hss.....p...sG.shaYRupF................s.u.ths......hshp.............hs.spuus.s.ht.........splalNGh.hGp.ah.......sshGsp.......................ssaslPp..ulLsh...p........sslhsslhs..t..............................	0	96	180	272
+13207	PF13365	Trypsin_2		Trypsin-like peptidase domain	Bateman A	agb	Jackhmmer:C0AF95	Domain	This family includes trypsin like peptidase domains.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null --hand HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-11.06	0.71	-4.12	318	12156	2012-10-02 13:45:52	2010-09-19 13:18:49	1	253	4752	80	3773	11497	4680	143.10	28	31.28	CHANGED	GoG..h....ll...ssss............................hllT.s.................tHVlp...................................................................ts.pplthhhhsspp.ht...................................................uplhths.....t.................................hDl..Allplpsstttthshtssstthtssthhhhhh.......................................................................................httstshhhttthtstttttstphhhh.........................sssht.s.....GsSGuPl.hs...ppGp...llGl	..................................................................................................................GSG..h...ll.....sp.s.G...............................allT.N.................sHVls...................................................................................................................suspl.p....V..p.h.scucp..hs.....................................................................................................Acl...l...G.tDs....p..................................................sDl.All+lpssphhshhhhsss....................................................................................................................................sthshsssssshh...ssss.hhs.s.h.s.t.s...s..s..t.t.t......tp...h.....................................l....QTDA.u.IN..s...............GNSGGsL...lN....hpGc...llGI............................................................................................................................	0	1232	2423	3164
+13208	PF13366	PDDEXK_3		PD-(D/E)XK nuclease superfamily	Bateman A	agb	Jackhmmer:C0AD98	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily	22.00	22.00	22.00	22.10	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.26	0.71	-4.04	106	398	2012-10-11 20:44:47	2010-09-19 14:41:19	1	8	204	0	173	467	252	110.60	36	80.21	CHANGED	p-loppIluuAhcV+ppL.GsGhLEsVYcpuLthELpppGlshcpQhtlslhY+uhhlsp.apsDllV........psplIlELKu.VcplsshHpAQllsYL+hos..........hclGLLlNFss...h+.t.......h+Rl	.............................t.plshtIlssuhcVappL.GsGhLEslYcpsLhhEL.pppGlthpp...Qh.ls.lhY+s...hh..ls..p.a+hDllV........psplIlElK.u......Vc...p....l....t......s....hHpuQllsYL+hos..........hclGLLl..NFss....p.thpR.......................	0	96	155	171
+13209	PF13367	PrsW-protease		Protease prsW family	Coggill P	pcc	Jackhmmer:B0SDU2	Family	This is a family of putative peptidases, possibly belonging to the MEROPS M79 family. Swiss:B7GHM8, PrsW, appears to be a member of a widespread family of membrane proteins that includes at least one previously known protease. PrsW appears to be responsible for Site-1 cleavage of the RsiW anti-sigma factor, the cognate anti-sigma factor, and it senses antimicrobial peptides that damage the cell membrane and other agents that cause cell envelope stress, The three acidic residues, E75, E76 and E95 in Swiss:B7GHM8, appear to be crucial since their mutation to alanine renders the protein inactive. Based on predictions of the bioinformatics programme TMHMM it is likely that these residues are located on the extracytoplasmic face of PrsW placing them in a position to act as a sensor for cell envelope stress [1].	21.50	21.50	21.60	22.00	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.73	0.71	-5.11	184	1339	2012-10-01 21:07:14	2010-09-20 14:09:30	1	22	1111	0	303	941	360	189.90	23	55.85	CHANGED	pPhthllh.sFlhGshsuhh......shhlp.......thht..............................hh..hhts.hlhusllEEhsKhlslhhhh.......h.htppph..........sp...hD.Gl.lhusssuhGFAhhENlhYh....h.............................................shhts......hlhR.slhu.shuHsla...ouhhG..huluhst...htt...........t.....hhhhhuhl...huhhlHulaNhhhhh..........................hhhhshhhhl	.................................................................................hhhllh.shhhGshhuhh.......shhlp......................................phlh..h.........................tth.s.tshtsslsusllEEssKhlsllhhl..................................h...tthch..........................................spl...hs..sl.lhG...sss....GhGFAhhEslsYhhp.h...........................tt.s.........................sslsh............................hlhR..shhu.lsuHhla.oul..sG...hulslsh................pptt.............t.hp....hthhhhhl...hAhslHhlass.hsh.ts..h...............hl...hhhh.h....hhhhh..................................................	0	113	225	277
+13210	PF13368	Toprim_C_rpt		Topoisomerase C-terminal repeat	Coggill P	pcc	Jackhmmer:B0SHF2	Domain	This domain is repeated up to five times to form the C-terminal region of bacterial topoisomerase immediately downstream of the zinc-finger motif.	22.30	22.30	23.10	22.30	21.90	22.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-9.05	0.72	-3.49	42	3284	2010-09-21 08:44:24	2010-09-21 09:44:24	1	25	1144	0	1046	2994	3373	67.30	30	21.53	CHANGED	cPtsG.c.sh.V.+-GRFGPYV.....TcG...csN.....s.oL.+s..sss-slT...hccA............hp.LLA.-+.cA....+usu...+...K....p..s.Ap.K	............cPtsG.c.l..l..psGRaG.PY.l.....................p.c..G...........pss....................................u.oL.+...s.......ps......s..tslT........L-cA..................................lc.Llu...t.....+t...........tu.t........................ts.............................................................................	0	338	755	931
+13211	PF13369	Transglut_core2		Transglutaminase-like superfamily	Coggill P	pcc	Jackhmmer:B0SCJ3	Family	\N	23.50	23.50	23.60	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.91	0.71	-4.72	183	1446	2012-10-10 12:56:15	2010-09-21 10:38:47	1	21	1341	0	427	960	170	155.40	32	47.73	CHANGED	pthhtpLcplstcscpp.....lstp........................................................p........plp.tLtchhapchG.....FpGspp....sYhssc..........Nualsp.......VLcpRp..GlPloLullaltlAc+.lslslhuVsh.PscFll+ht.........................hhl-Pas.G.c....hlstppl.pthLpthhs............hp....hpsp.....hLp...sssspplltRhLs	......................................................................................................p..hhscL-pLsp.scpp.............lsp.......................................................................................................................................................hs.cp.............plc..tLhplFY..t-..h.G......................................Fpu..sps.......sYh.s-.................sha.Lcp....VL..c..p..Rp..G.slSL.......uslhLh......lAp+..LsL...PLhsVh.F.....Ps..p...h.lLRhp.....................s.-sp.........................hhIsPFs.G.c........pLspctL...chhLcsphus............sc...lh.p............Lp...tAsshpllt+hL.s.............................................................	0	135	239	341
+13212	PF13370	Fer4_13		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:B0S9J0	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.09	0.72	-3.58	110	1093	2012-10-03 08:56:43	2010-09-21 10:44:49	1	12	947	18	263	2183	451	59.60	39	58.75	CHANGED	V......D..ssCIsCssCtthAPclFphssctttshl.h......c..........p....sp..s..........pp-.....p.....ppshpAhtuCPssuIts	.............VD..-pCIA.CG...tCsshA...P..-...l....FD..a.-.D.-...s...ht..hll.h..........-.................c...sp..s....................-c............h........-shh-A.hc.uCPTcuIc.............................	0	91	192	235
+13213	PF13371	TPR_9		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:B0SCJ3	Repeat	\N	21.00	8.30	21.00	8.30	20.90	8.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.09	0.72	-4.12	103	4976	2012-10-11 20:01:03	2010-09-21 13:12:18	1	1320	2289	0	1951	43963	9522	67.30	16	14.49	CHANGED	LKthh.hppcchppALpsh-hlLhl.....tPc...ssh-hRDRGllhtpLsshpsAhpDLptal....ppsP.....pssssphlctplp	...................................................h.........ttp.h...p.A...h...t....h.h..p.....t..h...l..t..h.........................sP.p.................sst....h.....h.......h.......p........p..........u........h.....h....h.....h.......p.........h........s........p.......h.....p....t...A...h..p..s......l...p.t..hl............p.p.s......................pt.....................................................................	1	652	1138	1559
+13214	PF13372	Alginate_exp	DUF4104;	Alginate export 	Coggill P, Eberhardt R	pcc	Jackhmmer:B0SIJ8	Domain	This domain forms an 18-stranded beta-barrel pore which is likely to act as an alginate export channel [1].	25.00	25.00	25.00	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.22	0.70	-5.85	23	682	2010-09-21 12:51:04	2010-09-21 13:51:04	1	7	487	4	258	716	125	365.20	17	76.18	CHANGED	shlshGhslRtRhE.hssssthGstsstcDshllpchplaA-hchss....phphhlphpDsRsaspp.................sssssD..pNtlDlcpAals.......as.ssLs.stshc.lRlGRQchshstpRa....Iusp-h.NsppuFDulhhcac..s....spaRhpuhhspPsphhssph.s........DspscshpFsusphphps.hsssslpsYasthpcpsup..........................hhcssssc+hpshulRhsGpt.......sthDa-hEuhhQoGps....Gspshcua............AhuucsG..YTh.shshpPRlulphDhASGD........pcssDGslpoFssLFssut....aauhAshsuhuNLhpspsplolpP....ssplsh.suhthhWRtsssDulhspstss..............l.ssuGpuu.casGpthclR.............hc.ahhssphthtlcuuaFpsG-sl+susspssshsssp	...........................................................................................................................................................................................................t...phshphR.cht........p.t..........h............................t..t..s..t...t......h......h.........ph...thh.h..hphtt....................thphhhph..ss.h.h...st..t..............................tss-.......ps.thslpp..uahp............hp...tht..........s.....hp....hphGRQph......ths.s...p..+h..................l..u..s...hs........h...ss...t.p.s....a.D.uhththp...h.....................sphp.h........s.h...h...h.h.....p...s.............sth....................................cst..s.t..p.pth.h...s.....h...h....h......p......h.........p...............h......t...........h..t.......h.....p...s..ahh.thp.pptst..............................................ht...t..t...t..s.p.p.hpshGh.+htuph.................tths..a..phphhhQ..t..Gph...............sspshpuh................................uhts..p..h..G......a..ph...t...s.h...pP......ph..s.......h..th..sh...h.....SG.s..................p.t.ss.p........h.t.sF......p.sh....a.sssh...........................hhu...h..th...h.....t...........s.......N......l...sh..t...th.phps.......ptph.shthth.hh.hhh...pttsshhtts...............................................st..p...hGt.hph...........................hp..a.ht..ph..hththshh..up...hht..t............h.................................................................................................................................................	0	94	183	221
+13215	PF13373	DUF2407_C		DUF2407 C-terminal domain	Wood V, Coggill PC, Bateman A	agb	Pfam-B_17915 (release 21.0)	Family	This is a family of proteins found in fungi. The function is not known. There is a characteristic GFDRL sequence motif.	25.00	25.00	25.50	26.50	22.50	24.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.98	0.71	-4.26	28	151	2010-09-22 10:47:12	2010-09-22 11:47:12	1	7	140	0	116	144	0	129.40	32	39.30	CHANGED	hGFDRLLssGFoppElssLRpQFhulaus......ppss-shss.p..............slRpLE-pWh-ssus..................................tssts.s.ssphss.........hsssstps.-DLLhGhllGhFhGlhuhlaLh+--..Glas+Rp+hulhsGlhlNhsauhlRs	............................................pGFDRLL.ss.GFotpElstLRpQFhuhh.u......hppss-shssss...................clRpLE-pWh-ssus......................................................stss.s.tsthst................hssssttshcDhLhGhhhGFFaslhshhaLh+pc..ul..astRpphulhsGlhlNhhhuhh+.....................................	0	38	68	100
+13216	PF13374	TPR_10		Tetratricopeptide repeat	Bateman A	agb	Jackhmmer:Q7P422	Repeat	\N	22.00	10.00	22.00	10.00	21.90	9.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.33	0.72	-7.76	0.72	-3.89	291	5651	2012-10-11 20:01:03	2010-09-22 18:02:07	1	1557	998	7	3285	40335	8366	38.20	20	7.91	CHANGED	shsshssL.At..hhtpt.uchpcA.pplhcp.s.lphpcpl....hG.s.....cH....ss	....................................shpsL.ut......hh....tp....t..G.....c....hp.....cA..t...sl....hpp.s.lt.htpth...............................................................	0	1339	2317	2944
+13217	PF13375	RnfC_N		RnfC Barrel sandwich hybrid domain	Bateman A	agb	Jackhmmer:Q7P7C9	Domain	This domain is part of the barrel sandwich hybrid superfamily. It is found at the N-terminus of the RnfC Electron transport complex protein. It appears to be most related to the N-terminal NQRA domain (Pfam:PF05896).	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.17	0.72	-4.29	96	1912	2012-10-02 20:27:15	2010-09-23 09:15:51	1	35	1463	0	364	1936	307	94.90	37	16.91	CHANGED	hsF+.GGlHP.s-s.KphS.pspPIpph...hspclllPLpQHIGAPucPlVphGDcVLpGQhIucu.s.G.FhSuslHASsSGsVpuI-.+sssp.uo..t..s..p..sllIEsDGc	........................................................th..GGlH..P..c...Kt.o.pttslp.ph.s....h.s..p.c..hs.l...PL..p....QH.....I....G......A........s.up..sVpsGD+Vh+GQh..lscu.....p......G..hh.....ss...PlHAssSGsVsu.Isspsss.p.ss.t..h......slhIpsDu.............................	0	145	261	317
+13218	PF13376	OmdA		Bacteriocin-protection, YdeI or OmpD-Associated	Coggill P	pcc	Jackhmmer:B0SHC2	Family	This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice [1]. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S) [1]. YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein [2].	22.40	22.40	22.40	23.10	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-8.59	0.72	-4.32	168	1185	2012-10-03 20:18:03	2010-09-23 13:04:02	1	11	931	0	364	981	110	61.90	27	33.61	CHANGED	spshplP.sDltsALpssspAtthFpslstst+pshlthlt..sAK+scTRt+Rlpchlphlscsc	...............t...h.lP.p-lpstlp..ppPth.tstFpsLosutp+palhalt..sAK...pscTRp+Rlpchlphl.pG............	0	160	276	335
+13219	PF13377	Peripla_BP_3		Periplasmic binding protein-like domain	Bateman A	agb	Jackhmmer:C0AC70	Domain	Thi domain is found in a variety of transcriptional regulatory proteins. It is related to bacterial periplasmic binding proteins, although this domain is unlikely to be found in the periplasm. This domain likely acts to bind a small molecule ligand that the DNA-binding domain responds to.	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.04	0.71	-4.24	246	26367	2012-10-02 13:57:41	2010-09-23 13:14:04	1	51	3428	168	5469	22392	1655	160.60	23	47.18	CHANGED	scaL.hppG.a++lu....hls..............sttt..hsptRhpu........atpth.pptsht.sphhhhhttttt.tt..t..............................................................s.....s....Alhs..ssDthAht.lh.pshpp.t............Glp..l.P.cDl.ullu.hs........t......hh..phssP.sL.....o.olph.shpphu.ppAschLhph...l.......tstpts.pp.....hh.hss.p.llhR.pSs	.............................................................................................................................paL.lp.t.G.+.c..c.Iu....hls.............................sstph.tsspp.R.h.pG......................app...uh....p..c.t..s.ls...h...st...t...h..h....h..t...s...t......s...t.t.s.s.httht....................................hl......pth...............................................ts...........s......Alhs...ssDt.h..Ah..G..s.l.ps.h.p.c..t...................G.lp.........l....P....c.........D.........l...u..ll..G..aD.............sh.........hu....ph...h....p..P...sL........................T.Tl...p..p..s..h.p.p...h.G..ppAschLlpt.....l........................pt..t.p....h..s....pp.................hh....lss..p.LlhRpSs....................................................................	0	1692	3369	4443
+13220	PF13378	MR_MLE_C		Enolase C-terminal domain-like	Coggill P	pcc	Jackhmmer:C2D1R2	Domain	This domain appears at the C-terminus of many of the proteins that carry the MR_MLE, Pfam:PF01188 and MR_MLE_N Pfam:PF02746 domains.  EC:4.2.1.40.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.44	0.72	-4.09	1015	7138	2012-10-02 01:07:48	2010-09-23 13:18:26	1	22	2468	500	1681	7613	3271	111.80	23	28.55	CHANGED	sEp.h...hshtshpphlp.tsu.s.....t..h.lphcls+sGGlspsh+lush.Acshslt...lhsHs......ssluh.suslp.l..sssh.s.............s......hs..........h.h-................hh...h.............tph....ht..............s.h........s.Gh...l.tl..P.....t..P.....GLGlc	..................................sEhhtshhpht.phlp..ttu.l....Dh..lphchs+sGGlstsh+l..Ash.A.ct.a.s.ls............hssHu......ssluh...utshH.lss..ss..s............s...........hs.......h.pE............t.h.t......................ch........lp..................s.h..t..hc.s...Gh...l.ps...s..p....t..P...GLGlp...........................................................................	0	405	960	1336
+13221	PF13379	NMT1_2		NMT1-like family	Bateman A	agb	Jackhmmer:C0AC77	Family	This family is closely related to the Pfam:PF09084 family.	24.70	24.70	24.70	24.70	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.43	0.70	-5.00	82	4162	2012-10-03 15:33:52	2010-09-23 14:15:53	1	25	1726	8	1437	7965	1155	236.20	18	65.58	CHANGED	ssPEpspl+lGFIsLTDsAPL.llAtcpGaap+a....................Gls.l..plt+puSWussRDpll....sGplDuAHh.LhshshhhphGh...su.thshhsLhsLshNGpuIslusphhsthh..............hssssl+thhtp.pt........tshphAhoFPsuTHshhlcYWLAusGlcP...............pDlphlllPP.PQMVushcsGsh-uaCV....GEPWstpAl.tcslG..assh....oot-l.......WtsH..PEKs......husptcal-ppPssspAlltAll-AspahD..sstN+pcsApl.l....u	................................................................................................................t......tlp..lG..h...........h.h...t....h..h..sh....h....h.....u.t...p.....p.....s.h.hpct......................................Glp..l......phh...p..h.s...u...s.s.s...l..h..p.....ulh...............uG.plD..h..uth..hss..h..h...h...s.h.s.t.Gt......................s.h..h..s..h...s......s.....h...s...t......s.......G.....p.....s...l...s...l..p.p.t......................sshp.slt-l...............cuhplu.h..s.h.....s..u..s.p.p.h..h..l..p..h..h.L....t.p..s..Glss............................pDl..p.l.h..h.h.sP...s.ph.......s.s..u.h...p...s..G..p...l..D..u...h.s..s...........h.-..P..a...s....s...ts......t......p..s..h..u......phlh............ss..t.p.l......................h.s.sh.........s..t..ps...........hhs.pp....p....a.h..c..p...p..P...p..s.s..ps...h...lp...u.hhc...Atpa.....hp...t...t.....t....ttt.....................................................................................................................................................................	0	383	868	1164
+13222	PF13380	CoA_binding_2		CoA binding domain	Coggill P	pcc	Jackhmmer:B0SEN3	Domain	This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.45	0.71	-3.92	341	4531	2012-10-10 17:06:42	2010-09-23 16:03:17	1	30	2872	8	1431	4521	2487	121.00	29	26.68	CHANGED	+s.........lAVlGhS..s.pss+...suht.lhphLt.t.......pG.hplh.....PVsPp........pplhG.t.......t.....sassLs...t.s........tslD.....................hVslapssptsssllcch.hsh........s....scslWhQ.G...........shspcstphAcp......s.Glp.ll..spChtltts	.............................................................................+olAVlGAS..s..c..ss+.......s..u.ht....lh+.Lhp...........pG.....p...lh......P..V...sPph...................................ppl..h..G...............p................sYsols.........p..........PtslD......................lsslhpsu.c.ts.sllc-h..hpt.....G........s+.s.hh.l...u...................hhp.c.c.h.t.t.hAcc............t.G.hp...llh..s.pCltl...s.............................................	0	459	926	1215
+13224	PF13382	Adenine_deam_C		Adenine deaminase C-terminal domain	Bateman A	agb	Jackhmmer:C0A9T6	Family	This family represents a C-terminal region of the adenine deaminase enzyme.	27.00	27.00	27.50	27.40	26.40	26.20	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.68	0.71	-5.10	110	1480	2010-09-23 16:28:37	2010-09-23 17:28:37	1	12	1271	6	346	1189	171	167.40	36	29.18	CHANGED	spl.lTcchhhpl......pl.p...sGhh..ss..ppD..l.hKlAVlERapt.s.GslulGhlcGaGl+.pGAlAoolAHDSHNllVlGssDcDMhhAlsplhchtGGhsls........psGc.llupLsLPlAGLMSs.pshcpVscplpplpp.shc.p.lG.s.s.h.p...sPFhoLSF.LuLsVIPcLKlTDpGLhDVppaph	.........................s..h.Tp.h..ph....h..t....ss.h......s...p.p.D..l.shlAVlE.Raup.p....tsh.uhGllpGF....G..l.p..p.G.A.lAoTluHDSHNIlVlGp..ss--MthAsNplhphGGGhslV........p.s.Gp...Vhup..lsLPIAGLMSs.pshpp.lsc.plctLcp.Ahc.c..h..G...st....hs....cPFhphuF.LuLsVIPtLKlTspGLhDspphp...................	0	136	260	294
+13225	PF13383	Methyltransf_22		Methyltransferase domain	Coggill P	pcc	manual	Family	This family appears to be a methyltransferase domain.	21.90	21.90	22.10	21.90	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.90	0.70	-4.84	9	252	2012-10-10 17:06:42	2010-09-23 17:52:57	1	11	100	0	209	288	84	207.40	20	68.36	CHANGED	u.AsKcu.uFFDchhsshhpthpc+hh.Fpphspst.................ppcsttWY.-NlEPshTC...sp.pRlGs..tG.........-GsKWlCDPpRLhp..........pts-CLlYSlGSsscasFE-ulhc.lups.CEIHVFD...tshsps.ssp.pthaap.hGluuuh-.shss................hhsht-h..tLsH.htRTIDlhKIDCEtCEWusYtsWhssDs...cphLlElHu..............................Psppss...........spcFapthhcpsahhFpKEsNl.a...pptClEauaI+	...................................................................th.....................................................................................h........hhu......s.........................DGsp..h..lC.t.sp...t.h.........................................................pC.hlaSh..G.....h.s.sphsF..-tph.hp.hs...CclasaD......s.......t...p...t...t.......p....t.t......p.h..ha.....tph.........ulu....tt...s...s..p.....t...st.............................hsl.tslh.p..t.h...s....H.....t..p.h.l-lLKh.DlE......u....s.E...a....p....s..L.........p..s..h.l....p..p.th...................hpQlhhElH.h.............................................st..............................hh...p...t...htt.s..hhhat........................t................................................................	0	84	110	190
+13226	PF13384	HTH_23		Homeodomain-like domain	Bateman A	agb	Jackhmmer:C0A3L3	Domain	\N	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.92	0.72	-8.52	0.72	-4.18	345	2487	2012-10-04 14:01:12	2010-09-24 17:38:01	1	100	1542	3	717	11862	1498	45.90	20	22.10	CHANGED	stpttpRhp..hlthht...p........uhshpplAphl.s.loppolt.ch..hppa..........p.pG....hpulh	......................................t......h.t...hhhhht......p...........Gho.hppIActl..G.lo.csT.Vt.+h...hpp.........................t.................................	0	199	482	617
+13227	PF13385	Laminin_G_3		Concanavalin A-like lectin/glucanases superfamily	Bateman A	agb	Jackhmmer:C0A826	Domain	This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.36	0.71	-3.99	726	6160	2012-10-02 19:29:29	2010-09-27 13:17:45	1	933	1411	34	2404	8060	5104	168.50	14	16.23	CHANGED	p.u......h.h..h....sus........ss...h...lp..........h...ss......ts.................h.....s....ss.......sh........................T..lssWl..p.hs........s.....h.s......st..tth.....hh......................................s....ss..s.................sht.l...t.....................h.......s....ss.s............ph.t..h...........th...tss....s................................t.t.........php.....s.ss...........sh.s..................s....s.pW.pHlsh.s..hs.............u..s...................s.......hp....lY.l.......s...Gp........hhs...s..........t...s..t..sss........................................................................hs..............s..ss....h...................h....lG.........................ss.t................s.....s............spha.s.......G.....t.....l.D-lplas......p.uLoss-lp	..................................................................................................................................................................t..................t......h.........h....s........................h......s....sp.......sa..........................................T..lss.hl....p.hs......................s.....h.s.......st...tth....hh...........................................................t.sts.....................tht.l.t...................................................................h.........s...sss...............ph.th............thtss....t.................................................................................................thp.......s..ss..........sh.p...........................s.....sp.W.t.+..lsl.s..hs..............s..s......................................p........hp..lY..l.........s...Gp..........hhss........t...s..h..sss.........................................................................................................................ht........ts..ts..th...................h....lG.....................................................sst........................s.s.........tp.h..p.........G.....p.........l..spl.tl.as......p.sLsttpl..........................................................................................	0	1029	1475	2077
+13228	PF13386	DsbD_2		Cytochrome C biogenesis protein transmembrane region 	Coggill P, Eberhardt R	pcc	Jackhmmer:B0SI46	Family	\N	24.20	24.20	24.20	24.20	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.80	0.71	-11.67	0.71	-4.57	161	1138	2012-10-02 18:22:22	2010-09-27 14:35:20	1	9	1040	0	354	3522	1325	201.20	26	81.07	CHANGED	sshllGLh.Guh.HC...lGM..CGGlshuh.....sh.....st...........p.......p........p..t.....h...t.........h.lhYslGRlhoYsllGslhG.hlGs....sl..thh....st....h.....t..h....lph.hhu.lhhslhhlhhuhthh.h....h...h....hh..t........l....tp....ls.....ph.l...hphh....psh..tpph.........psh....hs.shhlGhlhG.hL...P.C..G...l..VYsslhhAh.so..G.ushpGulhMhsFGLGT...lPshlsh..uhhssh.l.........pt......hhp.......p.th.h.+..hs..ul..llll.h.Glh	.................................................................................h.hhllG.ll.uu....h..HC........hu.M....CGG.l.s....h.uh............shs............................................t..............p............p.h........h...h............h.lhYslGRl.....hoYsl.l.Ghl.h.G.hlGp....hl....s......st..............h....lph.hht...hlhslh.hl.h..h.u..hhhh..............t....hh..h...............................l........tp........h..s.........th....l...h..p...hl......p.l.hpp..........................psh..h..sshhlG..h..l..h..G..hl......P..C....G........l....VY.s.h....l.h....h.......A.h.s.s........u........s........s...hp.G.uL.hM..h..sFGLG...T.....lPshlhh.....uh...h.u...ph..l..............sp.........hhp...........p..hh...h...+....lu..uh..lll.h.hGl....................................................	0	126	259	317
+13229	PF13387	DUF4105		Domain of unknown function (DUF4105)	Coggill P	pcc	Jackhmmer:B0SCN2	Family	This is a family of uncharacterised bacterial proteins. There is a highly conserved histidine residue and a well-conserved NCT motif.	22.20	22.20	22.20	26.90	22.00	22.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.22	0.71	-5.09	149	716	2010-09-27 13:47:27	2010-09-27 14:47:27	1	1	544	0	199	698	188	171.80	22	36.56	CHANGED	ss......tttpahp...........thtssplphs.hhsu.hhspshshaGHohl+h..............hpsthh.......thshsaus.sh....sshshhh+uhhGpa.phhhshtshpchltpYsphct...RslaphpL.s.Ls.pptptlhtplhctt.shp.t.....htYpahpsNCoTplhchl.ctsh...sttlth......ph....hh.sh.............shhchltph	................................t.......phs.cplphl.hhhu.httpsh..shaGHThl+h................thtD.pp......thshsaushst.......sp..hhhcGhhGpa..hthss.hshpchltpY.sphct...Rslaphp.L.s.Lo.pctptLhtphhcht.phs.......hhY.ahssNCsoplhchl.ctsh...ss.l.hs....ph....hhss.............thhphl.p........................	0	69	127	171
+13230	PF13388	DUF4106		Protein of unknown function (DUF4106)	Bateman A	agb	Pfam-B_5 (Rel 25.0)	Family	This family of proteins are found in large numbers in the Trichomonas vaginalis proteome.  The function of this protein is unknown.	27.00	27.00	27.60	32.80	25.20	26.80	hmmbuild  -o /dev/null HMM SEED	422	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.65	0.70	-12.54	0.70	-5.51	13	401	2010-09-27 14:06:47	2010-09-27 15:06:47	1	5	1	0	401	401	0	270.60	73	66.03	CHANGED	MQKAMKSAEYIKANNDWLDAQANAKAAQLIGSIRTKIQADEDSSNEALTNADFKNAFEALHSKVK.VNDFSSGKKLKSEGFDKEL+EVAQNMTKITDAATRQAVQSAYDAVRATVVESQEKELQQTKTDLVNAFL+TKSQVGHYAADGTYVPAGGTYIPAGGTYILASGTYIPPNPPREAPAPGLPKTFTSSHGHRHRHAPK....PTQQPTVQNPA...........QPTVQNPA.Q...............QQPsQQPssQ..............PAQQPssQpPA..........QQP..QTEQGHKRSREQGNQEFLKMLKE-YGYPDTlDFSDRYKEAIRKFKEGNTDPNLFSFMAQHQIGYNLKPGKYKLAKGYDLIAYHPNDMsEFTPRYLMSELNDNSTlFMKRVKNRDGTKEERhMssDDLsRELVKNGLGIYEMPA.......DEVQETPQEE.VQIQPDMEEIVQQQQLEEP	..........................................................................................................MTKITDAATRQAVQSAYDAVRATVVcSQEKELQQTKTDLVNAFL+TKSQVGHYAADGTYVPAG.......GTY........I...................................PPNPPREAPAPGLPKTFTS....SHGHRHRHAPK........PsQ.......Q..PT...Q....ss............pPs.Qpss.t...........................s....Q.ss.p............sA......Q...P..osQ..ssA..........Q.QP....QTEQGHKRSREpGNQ-FLKMLKEsYGYPDTlDFSDRYKEAIRKFKEGNTDPNLFSFMsQHQhGYNhKPGKYKLAKGYDLIAYHPNDMsEFTPRYLhSElND..NSTlFMKRVKNRDGTKEERhMssDDLsRELhKNGLGIYEMPs.......DEVQET.Q.....EE......VQIQPDMEEIVQQQQLE..............................	0	401	401	401
+13231	PF13389	DUF4107		Protein of unknown function (DUF4107)	Bateman A	agb	Pfam-B_5 (Rel 25.0)	Family	This family of putative proteins are found in Trichomonas vaginalis in large numbers.\	 The function of this protein is unknown.	27.00	27.00	37.00	35.00	18.30	18.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-10.88	0.71	-4.54	4	582	2010-09-27 14:17:08	2010-09-27 15:17:08	1	2	1	0	582	582	0	140.50	87	90.96	CHANGED	MGTKALAFGAKALGAYDAVNKMSGGRVSKTLDANKGKIGGWVAKKLRLNKIGLINKASNLVATESENALGKDDEFAKHAKDFNDQMKGETMHLNRVDGTKENVSSPPAVhPYGPYGMYGNPYERPFDPLTGGSNWYHYGRRRKTVKLETDVKKATKKK	..................................MGTKALAFGAKALGAYDAVNKMSGGRVSKTLDANKGKIGGWVAKKLRLNKIGLINKASNLVATESENALGKDDEFAKHAKDFNDQMKGETMHLNRVDGTK....ENV..SS...P......P.....V..............VL.P..............Y......GP.....YG...M.....Y.G.NP.....YERPFDPLTGGSNWYHYGRRRKTVKLETDVKK.ATKKK.........................	0	582	582	582
+13232	PF13390	DUF4108		Protein of unknown function (DUF4108)	Bateman A	agb	Pfam-B_8 (Rel 25.0)	Family	This family of putative proteins are found in Trichomonas vaginalis in large numbers.\	 The function of this protein is unknown.	27.00	27.00	132.80	132.50	20.90	19.00	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.98	0.71	-4.44	38	686	2010-09-27 14:18:04	2010-09-27 15:18:04	1	1	1	0	686	686	0	131.20	85	97.24	CHANGED	TKFISVNKYMotlKEELDPFsYLNVYFYHFEKS.oFcKVWNIEPVKFAIVTK..NGApFEDL..DIEGLLsVKENFDR+FSpLcEGKAYKLVIPYEPKKADDYEYYESKIVEVQGKLGKKILESK.....PVFAPKEEENIDIDPE	............................sKaISVNKYMotlKEELDPF....sYLNVYFYHFEKS.oFsKVWNI.EPVKFAIVTK..NGAKFEDL..DIEGLLsVKEsFDRRFSNLKEGKAYKLVIPYEPKKADDYEYYESKIVEVQGKLGKKILESK.....PVFAPKEEENIDIDPE......................	0	686	686	686
+13233	PF13391	HNH_2		HNH endonuclease	Bateman A	agb	Pfam-B_14 (Rel 25.0)	Domain	\N	25.00	25.00	25.00	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.40	0.72	-4.19	198	1540	2012-10-05 18:28:12	2010-09-27 15:37:21	1	23	921	0	616	1405	179	64.70	29	19.80	CHANGED	Csl..oGhph................................lcAuHIh.Phu.........................h...tsp.....................................................sspNGlhLsssh..HphFDpthlsls	.....................................CsloGhp.......................................hlcAAHIhPhp.........................t.s....sss...............................................................sspNGLhLssph..HphFDpuhlulp....................	0	118	339	479
+13234	PF13392	HNH_3		HNH endonuclease	Bateman A	agb	Jackhmmer:Q7P8C3	Domain	This is a zinc-binding loop of Fold group 7 [1] as found in endo-deoxy-ribonucleases and HNH nucleases.	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.11	0.72	-4.56	226	1385	2012-10-05 18:28:12	2010-09-27 15:51:52	1	43	897	1	251	1201	508	45.20	27	24.40	CHANGED	hhhHRllaphh....hG....thP..s.s.h.........hlcHhs.s.s+....pssph..sNLchsoppcNtt	....................................hhHRllhtth.........hs........shs..p.s.h..........plsHls...s.s+.......tsN...ch.....sNLchsopppN...................	0	83	160	209
+13235	PF13393	tRNA-synt_His		Histidyl-tRNA synthetase	Coggill P	pcc	Jackhmmer:B0SA16	Family	This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.	21.20	21.20	21.30	21.20	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.92	0.70	-5.37	129	7540	2012-10-02 14:22:40	2010-09-27 16:44:42	1	40	5007	33	2112	6233	5624	291.80	27	66.39	CHANGED	GlcDlLPtcApph-pl+cpLl-happaGY-hVhPPhlEah..-oLlsGs.....ut.s..h.c......p.saKl.sD.p.oGRhlGlRuDhTsQlARlsAp.p.l....s..pp......tstRLCYsGsVl..+spsst..h......t..ss..REslQlGAELaGps.ulpA.DhEllpLhlcsL....t....sG.l...pplplDLuHsslhcsl.h.p.sss..lststpptlhstLppKshsplp.plst...t.....hs............tsh.t.phLttL....pLtGshcsLp..cAtph.lss.h...s.t..htt.slspLcpltshhpsh.....t.splplDLu-lRGacYaoGlsFssYs.....sG..hu..p..slApGGRYDplstt.F.....G..+..........sc.......PAsGFSl-lctL	.......................................................................................................GhpDhlPtp.hhh..ph....lppthpphh.p.paGappl.cs.PlhE.....h.clh..tp.th.................G-..s...s.c.............c..h..Y..p...........h...........................D......c.....s...............s...........c...............p..............l.......................s.LRs.-.h.Ts.s.h.s..R..hh.hp..p...h..........hs...................tsh+haY.hGshF.Rh.-.+.s..p...t..................G.....Rh..R..pFhQhG...h.E..........hh......G........s.....s..s...t....h......D.u.E..ll..t...hshchhp......t.....LG..l..................pp.h..p.l.clN..shs.h....h.c..........................h....p........t........t....h....p.....p........s....l....h......p...h...l.....p.............p.......h.....p.......h.....t.....t......l.......c.....c.h...h.p....c...........t.....lp..................................................................pp.....h....ch.Lps.h..........ph.p....s...s........t........p.........t.......l.t...........p.s.....h...t...h....l.....s...t...........................p..p.........u.....h....p.c.........h.ptltphLc......sh..............t.hth.p.l-.....s.l....l..R.G....L..D...Y....Y.o....t......slFE..h.......h..s.........................s....s.......hs....s..................slsuGG.....RYDsLlpth....tG...p......................sh.............PulGFuhGl-Rl...............................................................................................	0	694	1329	1754
+13236	PF13394	Fer4_14		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:B0SHY7	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-11.08	0.71	-4.08	151	9987	2012-10-03 08:56:43	2010-09-27 16:54:42	1	73	4097	8	2936	16021	4178	110.20	19	33.66	CHANGED	lFl..uGCsh...........pCp................sC......sttthcF................ssGc.hstphhspll.............hpssth..ttlsloG.GEPhh.hspt.hh.Llcpl+ppt.......hcIa.l.Tshohp...........th..t..hlu......hh-.llscGc	.................................................................h.......tsCs..l.........................pCp..........................................................aC.h...............s.t..t...t..h.sh........................................................................t.t.t..p..h...h...s...h..c..p...l..h..p..h.lt.............................h.tt..t.s.h.......p...p..l.s.lo..G....G.E....Ph..h..........p........t.......l...h....t...l.l.....c...t....l...p...p.ts..................hp.l..p....l..p..T.s.G.h.h...........................................hhttthh...............................................................	0	1066	2000	2532
+13237	PF13395	HNH_4		HNH endonuclease	Bateman A	agb	Jackhmmer:Q7P7J1	Domain	This HNH nuclease domain is found in CRISPR-related proteins.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-8.68	0.72	-4.33	93	798	2012-10-05 18:28:12	2010-09-28 10:39:15	1	12	747	0	166	2662	2689	53.20	33	6.29	CHANGED	shYoGctIslscLhs..tta-IDHIlPhS.hhhD........DS.hsN+VLstpphNpp...Kusc.sPh	........................shYoG.c...t..l...s..hp.pl.t..........h-IDHllPhS...h..h..hD...................Do..htNhVLsppptNpp....KusphP.......................	0	59	115	147
+13238	PF13396	PLDc_N		Phospholipase_D-nuclease N-terminal	Coggill P	pcc	Jackhmmer:B0SFY4	Domain	This family is often found at the very N-terminus of proteins from the phospholipase_D-nuclease family, PLDc, Pfam:PF00614. However, a large number of members are full-length within this family.	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.33	0.72	-4.29	441	4348	2010-09-28 09:45:17	2010-09-28 10:45:17	1	24	2893	0	835	2871	257	46.90	27	12.42	CHANGED	hhllslhs.llpll.tp......p....tss......ss+hsWlllllh...lP..llGsllY.llhGcp	.........................h.hll.lhs.h.lpll.hp.............c.....+ss.........ssphuWllllhh....lP..llG..hllY.lhhGp.........	0	273	568	736
+13239	PF13397	DUF4109		Domain of unknown function (DUF4109)	Coggill P	pcc	Jakhmmer:C7MCW6	Family	This is a family of bacterial proteins with several highly conserved characteristic sequence motifs, such as: APR, WxC and ERR. The function is not known.	25.00	25.00	58.90	58.50	21.10	19.80	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.57	0.72	-3.65	79	618	2010-09-28 12:50:06	2010-09-28 13:50:06	1	1	430	0	167	347	96	101.60	49	89.31	CHANGED	RuLRGoRlG......usShEo-+ss-hAPRpplpYhCss.GHphplsFAs...-AEl..PssW-C+.CGt.Aths..cus..sP-sp.tsKPsRTHWDMLhERRS.pELEplLpERLphLR	....RsLRG.plG......uhShEs-Rss-hAPRphlpYhCsN.GHchclsFAs...-A..El..PssW-C..CGh...Aths..cus....sPp..sc..sKP.....RTHWDMLhERRS.tELEtlLsERL-hLR.	0	60	130	159
+13240	PF13398	Peptidase_M50B		Peptidase M50B-like	Coggill P	pcc	Jackhmmer:C7M9M6	Family	This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.44	0.71	-4.93	100	639	2012-10-03 04:41:15	2010-09-28 13:50:45	1	11	589	0	249	815	96	197.80	26	80.07	CHANGED	ll..sh.llA.lhllh.s.....h....lht..........h........+hls....ohhHEhGHAlsAlLoGtclpuIpLpsD........pSGlsho..pG........tGhuhhlsshAGYhusulhGhshhh.hs..t.s..sps...sh...hL.h...lsl.s.l.Llsh.L.lhh.Rshhul...hhlls...huslhhslhhh...sss...ph....s.....hh...shh.....lulhlhl.uult.s....l...........h.-L........h......pt...t.st........pSDAstLAc.lTt............lP..uhhW..ssl.ahhl.ulssl.hhu	........................................hh..hhhsuhhlhhtt..........lhp....h........h........p.h.ls..............shhHEhGHslh....shLsGG.+sc.slhlhs..s.............................................pp..Ghslopu..............thh....u.h..........lo..shu...GYh..h..s.s.l......h.h....hh...h..lh...ss....th.....phs....sh.....hlh...hhl..h.l..hlhh...L.lhs...R.ph...sl.....lslhl......hsh..h..lh.hlhh.......tp........phhh.......hh.....shh.....hhlhlhLstlh.p...................l.........hcL......h...................pp.....ss........p.Du.......stLtc.lot.................lP..hhlashl.ahlhslhsl...h..............................................................................................................	0	91	170	223
+13241	PF13399	LytR_C		LytR cell envelope-related transcriptional attenuator	Coggill P	pcc	Jackhmmer:C7MGV9	Domain	This family appears at the C-terminus of members of the LytR_cpsA_psr, Pfam:PF03816, family	22.20	22.20	22.20	22.30	22.10	21.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.95	0.72	-3.61	203	1654	2010-09-28 13:27:52	2010-09-28 14:27:52	1	14	748	0	494	1394	193	91.50	23	24.14	CHANGED	sspls..V.pVhNuo.sh......sGLAuplustLps.p.GFs.s...sss..uNs....s......ss.....t.....spop.lh.a....usss.pss.A.t..s.lust..l....s...ss.p.lh.t.s....s...tts..s...s...lplll..Gs-aps	.......................tphpV.pVhNuo.sh........sGlAupsustLp.s...t.G...Fss...sss..uNt..s...........ss.....t.....spop.lha.....ssus....pss...A..p...plupt..l........s....ss..s...lt.t..s...........s.......tts....s............s....lplll..Gpsat..................................................	0	156	375	464
+13242	PF13400	Tad		Putative Flp pilus-assembly TadE/G-like	Coggill P	pcc	Jackhmmer:C7ME36	Domain	This is an N-terminal domain on a family of putative Flp pilus-assembly proteins. The exact function is not known. The Flp-pilus biogenesis genes include the Tad genes, and some members of this family are putatively assigned as being TadG [1,2].	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.38	0.72	-3.93	284	1158	2012-10-01 21:13:59	2010-09-28 16:26:36	1	8	766	0	467	1471	102	51.90	26	14.21	CHANGED	G...sss...lhs..lhhlsllh....hhuhsl.D..huphhhs+sclQsu...uDsAALA..u...........A...ts	......Gshs..lhu.lhhlsllh..hsuhul.Dhuphhhs.+sclQsA...ADsAALA.u......A....................................	0	144	280	372
+13243	PF13401	AAA_22		AAA domain	Bateman A	agb	Jackhmmer:C0A2E2	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.90	0.71	-4.01	168	4268	2012-10-05 12:31:09	2010-09-29 11:23:30	1	160	2155	9	1502	14349	3197	134.70	17	27.70	CHANGED	hp........ppshh......hlhGpsGsGKThshpphhpth.................................pspsl...hlpsssss.......ohppl.hpplhptlshthtt..........................sttphh.ptltptlppptt..................llllDEApp.L....s.....tphLchl..ptl........hs...........ppslsllLhGps.plpphl	.....................................................tt...tthhhlsGpsGsGKTsh..h....pp...hhp.ph.................................................................phphh..........hlp..ssstt...........ssppl...hp.....t...lh....p..p.l.s...h.thss.........................................................................................sttphh.....ptl...t..p...h...lppppt...................................................hllllD...E.scp..L.........s.................tphL.ptL........ch.l...hs..........................pt.h.t.l..l..lh..G........................................................................................................................................................................	0	443	929	1274
+13244	PF13402	M60-like		Peptidase M60-like family	Nakjang S, Hirt RP, Bateman A, Eberhardt R	agb	Nakjang S, Hirt RP,	Domain	This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity [1].	27.00	27.00	27.50	27.40	26.30	26.90	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.71	0.70	-5.52	67	818	2012-10-03 04:41:15	2010-09-30 13:21:49	1	49	547	1	178	859	44	289.90	27	25.67	CHANGED	sshp.sTGlYsssscplslpl.....tsspslplhlusp..scp...........tp.shhtppas....Lssupsplps.shGGllYlh.....ssstst.....slplplsu.uh.sPhahhGppop.p-Wpp.lpphs.uPhsElpscphllTs.sscsl+ph.....sDsptlhchaDchhptts.-lsGhscp..t..pt............+hVsclphs.huhha.uGYslhhsss....shppllsh.stht..ssWG.hHElGHstQps.sapas...u.ssEVTsNlaolhspcthh..sp.tpthp...........tsch.....ppshpalppspsphth................tshhhtLshahQLphhaG	.............................................................................................................................................s.shp.sTGlaA.stpplslph.....tssss......s..slpl.tlu...sc.hs.cchtp........th.tRs.sh..s..s.c.p.as..............Lp.s.s....p.s.phps..s.............aGGLlYlh.............sspsst...........ssphoh...su...ssp.....sPa...a........t.........pp......tc.......Wpp...hhps...................s...u.................P.......h.......sELpo-shlhTs.s...p...cs...lps.......................ss...s......p........ph.......h...cp...h.D..p....h...hps.h...s.c........h.hGhsp......t.s.sppp.hp........................+ass-lplu...huhha.o.GY.slhsssh.........s.s.p.sl......s.......h...ps.......l............s............sWh...hHElGHNtp....ps..shphs...............u..sTEVssNlhuLahpc.phh........sphpp.................htsch...phu..p.alp.p.s.sspt.h.....................sshspLhhahQLp.hht....................................................................	0	67	89	126
+13245	PF13403	Hint_2		Hint domain	Bateman A	agb	Jackhmmer:A3PK18	Domain	This domain is found in inteins.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.27	194	984	2012-10-03 10:25:13	2010-10-01 10:01:36	1	80	208	0	187	918	160	135.40	32	24.73	CHANGED	sCFssGThItTspG..hsVEsLpsGDhVhTtD.....sG...hpPlpWlGp.pp..l........h.sstsph..t.Pl+Ip..sGALGss.....hPp+DLhVSPpHRlLlss...sphhhuptcVLlsAcpL..........l..s...t.ss..l.p...tt......s...s.p....t.VsYaHlhh-pHcll.hApGs.sESahsGs	....................CFhsGThIpTs.pG.....hsVEsLpsGDhVh..Th.-............su......h..p...s..l..pWlG.p.p.p..h........th.ssst.sh..hP.lRIt..t.s.A.luss..........hPtcDllloPpHplhlp..............th.hlsA+tL..........Vs....u..tu..I.h....pp......s....hs..shsYaHl.h-..pHpll.hA-.Gh.sESahss.s....................................................................................	0	22	148	169
+13246	PF13404	HTH_AsnC-type		AsnC-type helix-turn-helix domain	Bateman A	agb	Jackhmmer:A3PS88	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.22	0.72	-7.78	0.72	-4.42	347	5527	2012-10-04 14:01:12	2010-10-01 11:47:45	1	33	2295	47	1669	9314	1799	42.00	35	25.97	CHANGED	l.DclDpcILphLppc...uRhohpcluc..plGLSsssstcRlc+Lc	.........lDclD+pILphLpp-....uR.h.s.h.s.cLAc..plG.....lSsssltpRlc+Lc..................	0	419	1008	1383
+13247	PF13405	EF-hand_6	EF_hand_4;	EF-hand domain	Bateman A	agb	Jackhmmer:A3PLV3	Domain	\N	25.00	14.90	25.00	14.90	24.90	14.80	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.69	0.74	-7.96	0.74	-3.58	793	5737	2012-10-02 16:17:27	2010-10-01 13:55:03	1	526	696	127	3421	36588	2275	32.40	24	8.28	CHANGED	plp..phFphh.D.ps...psG..hls.h.p-l.pp....hlp..............t.hu	.................hp.psFpha.D.p-........tsG......tls.h.pEl.pp....hhp................................................	0	1356	1922	2697
+13248	PF13406	SLT_2		Transglycosylase SLT domain	Bateman A	agb	Jackhmmer:A3PHY1	Domain	This family is related to the SLT domain Pfam:PF01464.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null --hand HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.63	0.70	-5.48	176	3080	2012-10-03 00:09:25	2010-10-01 15:54:35	1	19	1866	9	798	2548	2044	255.30	32	69.52	CHANGED	sapshltsh.pppAtppGlspsslpps....hsss.php...........tpllcht.......ppQs....Ehs.p..s......htcYhsth.ls.spRlppGpphh.ppatshLsclEpcYGVssplllAlWGlETsaGp.hhG..s....hsllcuLATLAa.-..t...........................RRssaF....cpELhssLpllccsp.lss.................pp.hpGSaAGAhGpsQFhPooahpYAV...DhDGDG+tDlass..ssDAluSsANYL.ppp.GWpsG.pshuhplpls..............tshsh.ht...s...hpsh............spht.thGlp.hsst..........s.......thts..pL...tutpG.........ss..aLshpNF.hlIt+YNpSshYAhuVutLA-	................................................................................................s..t..h.tth.pt.stttGhsttthpth..h...sts..ph...................tllph.........................ppQs.........thp..........s.............hhpYhpph...ls...tpl.pp..Ghthh.ppatshLp.chtppYGVssphllulhGlEotaGp...hhG..p....hpl.l....suLuTLua.s.h.............................RRtpaF....ptcLhshLhhhp.pt.p.hs.s...................p..h.pG..S..aAG...AhG.sQF............hPooatpYAV...DhcGDG+h..Dlass..ssDAluSsANYL.....ppp....G..WppG.tshuh.sp.h........tshp......t......h....h...........................................................s....tst..u.lhh.tsttG............t...ahsh.NF..slhcaNp.....S.hYAhulh.Lu............................................................................................	0	186	454	620
+13249	PF13407	Peripla_BP_4		Periplasmic binding protein domain	Bateman A	agb	Jackhmmer:A3PPI0	Family	This domain is found in a variety of bacterial periplasmic binding proteins.	28.20	28.20	28.20	28.20	28.10	28.10	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.69	0.70	-5.03	173	12924	2012-10-02 13:57:41	2010-10-01 18:32:26	1	44	2863	86	3019	24092	3112	255.70	20	75.86	CHANGED	lu.....lsh..stsss.ahpt....htpuhpptspp.hshphhh............ts..upsss.spQhp.lpsh.lsps........sc..ull..lssscs..suls.sslcp.ApstGI.s.Vls........aDss...........ssstphh..........hluh-stph...Gphtu................................chlscthssp............uplsll....sGsss.ssstp...tt....hpGh.pps.....lpp..................hs.plplhs...............................s.s.hssspuppt.hpslLs...ss.........l........sul.hu..sssshsh...........u....shpulpp.tuh..tsp..h...........lsGhDssstth.phl.............psGphp..s...slhpssh...th..uttuhphsh.ph..hp......Gcp	...............................................................................................................................................sh.h..thsss..ahst......hppu...h....p.p....t...u....c....p...huh.phhh.....................supsc....sp..Q....h..p.t...l.csh..l..s.ps............sc.....u.l.l........l..s.....s...s....c.s.........s.u..h...s.....s.....s..l...c...c.....A...p.........p.....t....s.....I....s...V.l.s........................hDpt...............hsp.s.t.h.s.s......................hl...u...s...D...s...h...p..s....G..ph..tu.........................................................................................c.hl.s..c.phstp...............................................uplshl....................t.G..ps..s...s....s.s.sp............tR.............tpG.h...tps...............lpp....................................s...sh.c.lls......................................................p......ss.s...h.s..t...s..p.u....h...ph....h...p.sh.Lp.................sp.s..............pl.......................................................s.ul..hu..ts..Dshuh....................G.........Al.p.A...lc...s...tuh.......ssp.hh................ls.Gh.D...u...s...s...p...s...h...pt.l.........................p.s..G.p..hs............s......o.lh.p.sst....th.u.t.h.uhp.hsh.ph...hp..s............................................................................................................................................................	0	815	1763	2389
+13250	PF13408	Zn_ribbon_recom		Recombinase zinc beta ribbon domain	Bateman A	agb	Jackhmmer:A3PQ69	Domain	This short bacterial protein contains a zinc ribbon domain that is likely to be DNA-binding. This domain is found in site specific recombinase proteins. This family appears most closely related to Pfam:PF04606.	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.33	0.72	-3.71	726	3758	2012-10-03 10:42:43	2010-10-01 18:35:27	1	37	1459	0	677	3269	314	62.10	23	12.28	CHANGED	hL..s..G..l..lhCup.......CG....p...s.......h.....tt..........p.....p....pp........tpt.....................hh..Y....tC.s....st...h..pt.t...................p.....Css..p......plpt.ptl-...phl...hpt...lp	...............hsG..l..lhCup........CG......s.s.......h..tt..........p....p.....pp............ppp...................th..Y..tCs....pt.....t..pts........................p...Cstp......plpt.chl-...phlhptl........................................................	0	325	545	625
+13251	PF13409	GST_N_2		Glutathione S-transferase, N-terminal domain	Bateman A	agb	Jackhmmer:A3PFR8	Domain	This family is closely related to Pfam:PF02798.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.50	0.72	-3.98	315	3673	2012-10-03 14:45:55	2010-10-04 11:15:34	1	29	1984	30	1074	16648	5196	85.80	29	29.54	CHANGED	hs.Pas..p+shlh.Lpht.....ul...s.hp.....h..p.h................l............t.h..................p...th.......................................................h.p.hs......P..t..s..................................................p.....lPsLhh.............................t...sup.............sls..-S....tsIhc.aL.ppt	......................................................sPhu..p+shIh..hc.h...........GL.....-...h.....l..sh.................s.........hh..htps.....................ph..u.ss.F....................................................................................................s.c.hs......s..p..s...................................................p....VPsLhD...................................c...psp...............llss...ES.up.Ilphlsp....................................................................	0	300	612	885
+13252	PF13410	GST_C_2		Glutathione S-transferase, C-terminal domain	Bateman A	agb	Jackhmmer:A3PFR8	Domain	This domain is closely related to Pfam:PF00043.	24.90	24.90	24.90	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.27	0.72	-4.08	279	7419	2012-10-03 01:14:49	2010-10-04 11:42:28	1	51	2398	100	2549	11894	3037	85.10	19	31.76	CHANGED	pth..hpp................................................h.htp.....ltpsls..tl........cp.p.hs.......................................pt.............hh.Gs.......phohuD..hsl.h...s....hl...t.h.h......phh.....hh...t.h.......................thh.......p....t.h..spltsah.cp	...............................................................................................................tt................................hhtp.....hhptLs....hL.........-p.t..Lu.............................................................................................ppt............als.Gc.....phohAD......htl..h...s.........hl.....h.p...h........phs........hh...t.h................................hh........t.......s.h....spl.tahp.t........................................................	0	615	1327	1986
+13253	PF13411	MerR_1		MerR HTH family regulatory protein	Coggill P	pcc	Jackhmmer:C2D3E8	Family	\N	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-8.89	0.72	-4.20	214	18606	2012-10-04 14:01:12	2010-10-04 13:16:52	1	99	4180	5	3931	16622	3391	68.70	27	35.72	CHANGED	hsls-luchhsl........stpslRaaccchh...ltssc....pspsh.+hYsppclpplphIppLhp.pGholptlpchlptt	..............................hpIu-luch.s..u..l..................osco...LRaY.....-.c..pGL.....lp.Ptc..........spsGh...RhY......s.p...p-lppL.phIpphpp..hGh.sl.p.p.lpphlt..h......................................	0	1233	2583	3343
+13254	PF13412	HTH_24		Winged helix-turn-helix DNA-binding	Coggill P	pcc	Jackhmmer:B0SAM5	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.74	0.72	-7.77	0.72	-4.57	608	12234	2012-10-04 14:01:12	2010-10-04 13:54:13	1	121	3550	54	3360	26657	3880	46.50	30	21.83	CHANGED	hDphDhcIL.phLpc..su+.lotp-LAcplu..lSsssstpRl++LccpGlIp	........................hsph-hpIL..ph.Lpc........suc..l..otp...-L....Acplu......LSsssstcRl+cLccpGlIp................	0	820	1884	2697
+13255	PF13413	HTH_25		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:Q87B38	Domain	This domain is a helix-turn-helix domain that probably binds to DNA.	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.74	0.72	-4.33	195	2987	2012-10-04 14:01:12	2010-10-04 14:51:59	1	16	2861	3	621	3650	1038	61.70	32	21.10	CHANGED	hL+psRpppulolcclupph+lphphlpAlEpschs.tLP....ss....sas+Gal+sYAchLG.L..Ds...p...tl	........L+puRcphGlSlpplspchplphphlpulEpscas..tlP....us....sasRGalRpYAchlsl.-spp............................................	0	195	382	519
+13256	PF13414	TPR_11		TPR repeat	Coggill P	pcc	Jackhmmer:B0SDR7	Repeat	\N	26.80	26.80	26.80	26.80	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.52	0.72	-4.33	458	62040	2012-10-11 20:01:03	2010-10-04 16:34:37	1	8099	4563	105	30435	78055	23252	67.00	19	21.46	CHANGED	p.p...u..t..t..h.pphGpt.hh.p....p.t..c..hppAlptappu.l...p...h......s.......s.s...s....sp..........ha.hs..h...uts.hh..ph....s......p..p..hp....p.A....hpt..h..p.p.u....l.p......l.s..s	...................................................h.hth.G.h..hh..p...................t...s.......c.......a...p.p.A..l....p...t....a...p.c......A..l..................p.............l................s...................................P..p.......p........sp...............................................sa..hs.........h.........uhs..h.h.......p.h........................s..............................p....hp..............p.A..........hpt..h..p.p.A..l.p.ht...............................................	0	11553	19108	25290
+13257	PF13415	Kelch_3		Galactose oxidase, central domain	Coggill P	pcc	Jackhmmer:B0SIN7	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.56	0.72	-3.69	122	3739	2012-10-05 17:30:43	2010-10-04 16:49:49	1	745	564	0	2451	13422	417	52.60	26	10.03	CHANGED	ss..tlhlhGG..hs.........t..tpth....ssh.h..hh....sh....sss........pap......ph........ss...h....ss.....sRtsassshh	..........................................splhlFGG......hs.......................t....tphh....................sDl..a....hh.......cl...........sst.......................................pWp.............pl..........................tus........h...........Ps...........sRssHsssh.h..............................	0	922	1445	1978
+13258	PF13416	SBP_bac_8		Bacterial extracellular solute-binding protein	Bateman A	agb	Jackhmmer:A3PHX7	Family	This family includes bacterial extracellular solute-binding proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	281	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-12.25	0.70	-4.67	141	17239	2012-10-03 15:33:52	2010-10-04 17:51:20	1	26	3652	65	4107	24014	7960	298.20	16	73.07	CHANGED	phscpa.p....c.....p....s..s.......l.p..lp.htp..h..ss..s.-..h..spl...pst....ht..s...s..s..h..ss...h...sl...hhhs.sst..h.tphsp....ps...hlh........-l..s.............ph...t.phsp.........................................h..ss......hhpsh.......sh..cu.........hu..hP.hshs.s.sh..s................hhYspshh.........p.c...............s...........ss...poh.s.......sl......h.......c.....hp.......t..h................t......Gp.h..........................sh............h........p....s...s.....h.s.......hh...........hh.t.hhs........................sGt.t.h..sps.........stsh.......................sps.hphh.pp...ht....s..p..h.....h........hh................s.s..s...s...s..shs..ths......sG..c..sshhh......s....us....hs...hs...s.hp..................pt..s........t......s.hs.....h.........s......h.........s................p...........p.......u..........s.hh.....ss.p...s......hs..l....st....s...ss.pp...ph...tuhcF.l..pah.s.s.s-.spt....p....hhp....ttuh..h.P.sppss..t..t......sst....hp.......ps......st..h.s	..........................................................................................................................hhppF.p....c......p.s...s..........l.c..V..p...hph.......h....st......s...p...............h..h.....t..pl.........pst...............h.t....s..........G...s.......s....s.s......h.....s..l............hh.s.s.....s.s.h.......h....s..p...hhp..................ps.....hlt.......sl.s.............ph...s..phpp......................................................l..ss..........hhp.sh................sh...sG.p..............................hau........l..P.....h.....h..h.s....s..........h....s..............................................l.h..Y..N..p..c..h..h...................c.p....................................t..........................ss....p..o...W...s........-l..................h......p...........t.............ch.........................p..........sp.h......................................sh..............h.........s.....s.s.....p..t...........hh............th..h..hht............................................tGh.s.h..sps................sstph..................................tps..h.p..h..l...pp.......ht....s...p...h........t..........h.h...............................s..s..s.....s......p....h.....ts.......hh..t.............s...G.....c........s.s...h.sh............s..........hs.......hs....hs.....t.hp........................................pp...s.....h...........s..hs.......h...........s........h.........P................................................p.........p........u.............s.h.h.......ts..s....s........hs.....l.........s..p.......s.....up....sp........c.......Ahc.F.l........sal..h..s.s.....-...stt.........p......hsp........thuh...h..s..s.p.p..s.s.h....t..................................hh.............................................................................................................................................................................................	0	1273	2551	3313
+13259	PF13417	GST_N_3		Glutathione S-transferase, N-terminal domain	Coggill P	pcc	Jackhmmer:B0SCP7	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.38	0.72	-3.75	216	16191	2012-10-03 14:45:55	2010-10-05 09:52:41	1	91	2388	143	5495	19464	7212	77.70	24	34.58	CHANGED	La..s..h.t.SPas..p+lph.sLphps....l....s.....hc..h.....h......h..s.......sh.....p...p.......s..t..h........hth..s....shs...plPsL......h.p.s.....up.......slt....-S.t.sIh.ca.L...-pths.........ss..s	...................................................h...h..ss......hs......t..+....l..pl....s...L..pt...p...u............l........s...................ac...h........h...................tl....s...........................ht..........p....p............ss......p..h...........................hph..N...........P.ts..........p.VP.sL..........h..c..s.......st.............................slh.......ES..t...sI.hcY.L.scpas....t.....................................................	0	1291	2807	4225
+13260	PF13418	Kelch_4		Galactose oxidase, central domain	Coggill P	pcc	Jackhmmer:B0SIN9	Repeat	\N	21.60	19.00	21.60	19.00	21.50	18.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.49	0.72	-4.19	84	4909	2012-10-05 17:30:43	2010-10-06 13:08:44	1	961	757	2	3302	16453	618	51.00	22	10.48	CHANGED	sRhtts.ssh.h...ss..s..p.lhlhG.Gpsss.s........thhs-h.a..h..a....sh..ps..s..p..W........ppl.......s..sh..Ps	..................................RhsHo.ssh.l..........p......s..........p..lh.la....G..G....h...s..s..s..t.....................................ph..h...s...D...l...a.......h........a........ch.....ps........p........p.........W.........p.h....................t.............................	0	1424	2079	2760
+13261	PF13419	HAD_2		Haloacid dehalogenase-like hydrolase	Coggill P	pcc	Jackhmmer:B0SBQ3	Family	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.05	0.71	-4.05	169	33740	2012-10-03 04:19:28	2010-10-06 14:29:26	1	189	4905	123	8845	29816	9459	180.80	18	75.44	CHANGED	llFDlssTL..h...s..hph........hhhpth.......p....p..........hh..hcph.......sh..s...........hp.tpp.....hcp.......h.......h.......thsh..t.....ph...................ltp.lh.....pph....s.hp..................st..ht....p.thpph.............th.....th..t...h.hss.ssp.hlppL.p...p...thpl.hlh.oss..s..t..tt.hp.t...hhpp..h....sh.....thac...tlh.su...p..p..ht.h..h...KPpsts.apthhpph.....sh.ss...pp....h....lhlsDsh.psl..ts.Ap.shGhps.l.hl	......................................................................................................................................................................llFDhDGT.L....h.......D.....st...................hh.h.ps.h..........p.p........................................h....h.pp.h...................sh.....p...................hs....pp............htp..................h..............h......................s.hs.h..t................ph.....................................................................hp..t...h...h......t.t.h.....s..hp......................................................htt..hp.....p....hh.tph....................................h.....pph......p......h..h..s...s.....s...h....c...hL.p...p...L...c..............tp.........s..h..p..l....s..l..s....oss...............s................p............ph...hp...t..............hl.p.p......h..............................slt........ph.F.......c............tl.h...su................p.....p........ht...t....t........................K.P.p.......P..c..h.......a....h......t......s....h.p.ph.....................sl...ss........pc.....................s..................lhl.s.Dsh.ssl..tu..Ap.su.Ghps.hh.......................................................................................	0	2568	5341	7324
+13262	PF13420	Acetyltransf_4		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:B0SAL8	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.84	0.71	-4.27	21	5238	2012-10-02 22:59:21	2010-10-06 17:18:10	1	36	2675	35	970	25638	3580	151.00	22	79.81	CHANGED	IRhlppcDht.tlhplh..pp...hhpt..th.s.....hth...sshphhc.chlpph.....p.....s..phhahlhc..sspllGhsplp..th...ch...pppps.lp.hhhh..tpspcpslspc...lhstlh.pah.cphslcplhssl.sss.......Nh....s........uhhFapphGFchhGh.+ssthhts.cahDhhW	.............................................................................................................lR.hp..tDh....t...t........l.....h.....t.....lh.........sp....h....h.........pp.......th...s................h..p.........................s...h...p.......p....h.....p.......p.....h......h.....c.....p...h.............p...................tp.........p.h....s...h.....h....V........t..........c...................s..........s..........p.........l....l.....G.....a..u...s.hs......sh..................cth...................shca.....s.....s.....E....h.........u......l......a.....lp........ssh...p..G..+..G..l.Gpp.........L.l.p.t.ll..ph...A..........c..........p......t.....s.......h....c...p.l.h..s..s.l...hsp................Np........s...............................ul.p.L.a....c.p....h....G.....F...p.h.h.G.t.h.p..p.s.t....h..h......s...p.ahD...h................................................................	0	272	584	802
+13263	PF13421	Band_7_1		SPFH domain-Band 7 family	Coggill P	pcc	Jackhmmer:C1ZGV5	Domain	\N	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.36	0.70	-11.13	0.70	-4.82	24	734	2012-10-01 22:02:33	2010-10-06 18:16:45	1	19	672	0	189	878	126	216.40	26	57.04	CHANGED	VWRF.RasNEIKhGApLsVREGQsAVFVpEGQlAD.VFsPGpYpLpTpNlPlLoTLpuWcaGFpSPFKuEVYFVNTppFssLK..........WGTpNPlhlRDPEFG.PVRlRAFGoYuhRV.sDPupFlpEIVGTDGpFTs-EIstpLRslIVpc....FuchlupotIPlLDhAANhs-Luchltptlssch.scYGLslschhlENISLPp...EVEcALDKRoSMGl	...................................................................................................t.p..IppGotlhVtpuQhslhV...pp....Gpl.h.D...s........h.p.sGh..Ys........lp..o.s..........s............h.............P..............h.........l..............p..o..............l............p.p............a........p.......aG.h.p..o....Ph........c.pcVaFlNhpchhshK..........a.GTs..s.P..l.....ht.....Ds....pa......s...................ltlRA..aGsYoh+l...sD.........P.h...h.F....h..s..p......l...l........G....s...p......s...p...a.s...h....s-........l..........p....p.....pl.pu.........llst................lp...s...s....l....s....p.....p...s...h.....s....h..h...pl...s..u...p.t.t-l.uphl...pp...t.l.s..tp.a...pph..Glplsshtltul.oh.s-......-spchlpph................................................................................................................	1	75	138	165
+13264	PF13422	DUF4110		Domain of unknown function (DUF4110)	Coggill P	pcc	Pfam-B_8504 (release 24.0)	Family	This is a family that is found predominantly at the C-terminus of Kelch-containing proteins. However, the exact function of this region is not known.	27.00	27.00	30.90	29.60	26.90	25.80	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.27	0.72	-4.15	56	186	2010-10-07 10:44:02	2010-10-07 11:44:02	1	38	161	0	138	184	0	96.20	32	14.76	CHANGED	tpsssp-shPpP+.PFEoLR-FasRTuspWtphhhsphc....tt............ssK.................EL+KcuFcLuE-+aW-pR-tlptl...E-ppE-.uGlt-llt.tpct-ss.sss+p..........R	.....................................t...shpDshPpPc...PhEoLR-FasRTstpWtphhhsphc.t...........hssK..................EL++cuF-LAE-+aa-tRctlptL...E-ppE-.uuhtEssshspptp........pt........................	0	37	82	120
+13265	PF13423	UCH_1		Ubiquitin carboxyl-terminal hydrolase	Coggill P	pcc	manual	Family	\N	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	295	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.12	0.70	-4.98	21	393	2012-10-10 12:56:15	2010-10-07 16:51:41	1	11	243	0	279	8427	287	334.80	20	34.06	CHANGED	sGLEs.phs.ssYhsuLLQhhah.p.shhphlltps.................p.hcpsLhsELuhlasMLc.s...ss.uhssQsoNhLp.shuth......p............Auslst...............................ppslpp...sppFllcplphslhsh...............hhs.........................................................................................................hpsplsp.hhshph.ppt+s...hpsps.....pp...+.s...shhshslshss.......psp.......................................thshsshLcp..hpppp.pp...hhsppspph..ps.........................................................................................................................................................sp.shphpphP.lLsIshthts.p....h...s..hphsp........................................................hltlPhp..hslsph...............................htp-..tppt........shssphhYpLpulVCc..lss.shp.psH.hVShlRVs.......tp..................pc..................WalFND....ahl	.............................................................................................................................................................................................................................................................................................................................................................GhEs..phs..ssY..hsu......l.....LQ..............h.h........aa....h..............h.......h...p....h...h....l...p..ch...........................................................s.....h....c.........s...L....h.....s.......E......L......u...........a..........l....a....p.....M...L...c...t......................up.....s.........s....s...p....s.....o.......N.....h.....l......p....s....h.........p....p.h.............p.........................sss.lth.................................................................................tphhpp....hp.p.F.l...lp.p.l.p............p....h.h..ph..................t.....................................................................................................................................................................................................................................................................................................................................................................t...............l......t.......p....h.......h...s..h..t..h......t...........p..ps..............p.stp..................pp......hp..s.......t.h...h.....h..s.....ls..hss..............psp..................................................................................................................................................................................................................................................................th..s..h..t....p..h...L....c..ps......h.p........p...p...psp...............shCp...p..C....p...ch.....p.s....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................hp..p.p..p...l...p.....p.........h....P....s...l....L....s..l.s..h.ph........s.p...........phh..........hp...t............................................................................................................................................................................................................................................................................................th...ls......hp....hp..h...h.h......................................................................................................................................................................................................................................................................................h.tp........t.t.......................t..s..h..h...Y..pL..u.hV....sc....lts....p..hp.....t.sp.h.........V.u....h...l.+..ss...........p.p.................................................................pp........................................................................W.hhFND.....hhl....................................................................................................................................................................................................................................................................................................................................................................................	0	88	148	232
+13266	PF13424	TPR_12		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:B0SDL4	Repeat	\N	32.60	32.60	32.60	32.60	32.50	32.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.70	0.72	-4.04	266	22703	2012-10-11 20:01:03	2010-10-08 09:43:34	1	4096	2284	44	13792	31171	6927	76.00	21	24.33	CHANGED	p....p...h...s....p.s.h..t...pl.u.thht.phschppAhphhppulph..hp.t..h..u.p...p..p...ph.s.ts..h.tsluphhtt.hs..c..h..pp.Ahphhpculpht...pp	.................................................h..ts.h..s........sl.u.t.sht..phG.c......a......c...cAhp..ha.p.cuLpl...tp........h.......G..p............p........p..s..p.......h....u.ps.........h..ssLuts.a.....tp..hG.......c...........h......cc..Ah.p..hapcuLph...t...............................	0	7608	10139	12329
+13267	PF13425	O-antigen_lig		O-antigen ligase like membrane protein	Coggill P	pcc	Jackhmmer:C1ZFT0	Family	\N	33.00	33.00	33.00	33.00	32.90	32.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.27	0.71	-4.20	326	5848	2012-10-01 22:04:45	2010-10-08 16:03:28	1	44	2998	0	1467	5882	1859	156.00	16	35.08	CHANGED	+.h.......h.......h..h.......hs.hhhh..hhslllotoRs.u....hlshhlsh.......hh..hhh.................ht..h.ph+.............hhlh.........hsh..ls..lhslh.......hhh......................hh.tt..l..............................................p...ps..s.o.hss..Rh.p..........h.h......p..thh...p.hh........tp....t........s...h....hG.....hG.......h.s..sht.........................th...............thhh.s.....csh.............a...hp...hhhp.....hGllGhlh...hhshh	.................................................................h...hhhh..hhhh..hh.s.l.h.h..o.t.S..R.s..u......hluhh.lsh.......hl....hhh.................................................ht.tph+......................hhlh.........hsh..ls..lsslh.......hhh........................thht.h....................................................................................................................tt..ps.s.ohss....Rh.t..........h.a.............p.tuh..p.hh.............tp....p........P....h.......hG.......hG.........hsshh...............................................................hhhtsHNh..................a.lp...hhhp.....hGllGhllhlhh.h....................................	0	494	986	1232
+13268	PF13426	PAS_9		PAS domain	Bateman A	agb	Jackhmmer:A3PI49	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-10.17	0.72	-3.65	245	26423	2012-10-04 01:10:46	2010-10-08 17:13:29	1	3737	3198	105	10645	42862	3384	103.90	18	17.69	CHANGED	ssu...lh..lhst....p................splhhsNpsh...tphh...Gh..s...........t.p.....cl..h..u..p.s................h.p...t..lh............................s....tt.....t...........p...t.p..h.h......pp...........ltp..th.p..............ptp....t....h.....p.h..c.hhh...h...p...p.s.......................G....p......h..hhtlphtsl...........hs.p..p..sphh........th.ls..hhp....D...loc	....................................................ulh.hh-.......c..........Gpl.h.h..s.N...p..s..h.........p.c.hh....Ga..s..............t..c......E.l....l....G...p...s................................h..p..........l.h.............................................................................................................s.....sp......t....................t....t...t...h..h...........pp..................h.h..p....tl..p..........................ps.p.........t......h.........p.t.....-....h..th.....h............p......+..s..................................................G.......ph...........h...hh..p..h...s..h.s..s.l..........................................hs..p..p.......G.p..h.h...............th..ls...hh.p..Dlo....................................................................................................................................	0	3685	7467	9280
+13269	PF13427	DUF4111		Domain of unknown function (DUF4111)	Coggill P	pcc	Jackhmmer:Q2YCQ2	Domain	Although the exact function of this domain is not known it frequently appears downstream of the family, Nucleotidyltransferase, Pfam:PF01909. It is also found in species associated with methicillin-resistant bacteria.	22.20	22.20	22.30	22.40	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.28	0.72	-4.20	35	1222	2010-10-11 10:57:40	2010-10-11 11:57:40	1	5	685	0	86	694	11	106.30	45	40.45	CHANGED	Ap-lFsPVPpsDhhcA.lp-olspW......sDhpGDEpN.......l...lLsLuRlWaolpTGpIuuKDtAApWslpRLP.scapslLptAppuYLGptp-shst.psppltsFlpah+ppI	...................................A-clFsPVPcpDLhcA.Lp-oLshWp.......u.sDas...GDE.....RN..................V...VLTLuRIWYoss..T..G......+IusKDVAA-WAhc..R..LP.spa.psllhcA+p.uY.LGp.c.-Dchts...pssplpcFl+asKscI............................................	0	28	51	68
+13270	PF13428	TPR_14		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2Y691	Repeat	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-8.26	0.74	-8.82	0.74	-2.80	819	700	2012-10-11 20:01:03	2010-10-11 12:02:20	1	232	562	0	291	7605	2621	43.80	22	8.89	CHANGED	h.p.h..h..h..t..h.u..p.h..h..h..p..t..u..c...h..p.p...Ahp.h.hpp..h...h..p....t..t..s...s..s...s..p...hh...hth.up..h	....................h..hhh.tl.Aps..h...h.p...t..G...p.hcc...Ahphhcps...Lp.....t.s..P...s.s.......p..uh...htLu.....................	0	121	209	262
+13271	PF13429	TPR_15		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2Y889	Repeat	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.81	0.70	-5.34	27	995	2012-10-11 20:01:04	2010-10-11 14:33:27	1	217	880	3	284	2894	1122	173.90	17	26.66	CHANGED	+l...t.chts...p..ps.h.th..AshhasptchcpALplL.ssscpts.ss-s.....taWRshApLAhsLpc-DtuptAYcpLLssstA.pssDhsphlth...h-usPhcAtclu.huac+s+ssptLppAl.hhpptcsapcltsLLts..hp..t..tst....Ap...pSshhhssRAchhcppGpspsAh+.h+cAlshssusspl+usLLWhLlDtGppsp..h+.hLstacsph.....pDusLWtsaAuAhLhLscsspALpahpp.ptpptppD.LhhhuYADAh-huGpt-tAhplRRpsa+pLpc	............................................................................................................................................tttt.................................................................................................................................................................................................................................................................................................................................................h............h.h........h....h.....p..h....p.......p....h..t....p.......p......h...hpp......h........p.....t.t..............................ht.............s..s.......h...a....h....t.....h...A...p...l.h.t.p.h.s..p..h..st.A...h..pshcp....A..Lc..l...p...P.....s.....s....s....p....h........t.......s.....h....s.....h....h....L...h.....p....p...t..p..h...tp.........h..t..h..l...p...t...hh...pt..............................ss..s..t....h....h..........t....h......u....h......s...........t..h...t..p...........t..s......th...hp.......................................................................................................hhht..........................................................................................................	0	84	161	223
+13272	PF13430	DUF4112		Domain of unknown function (DUF4112)	Coggill P	pcc	Jackhmmer:C1Z9H4	Family	This family has several highly conserved GD sequence-motifs of unknown function. The family is found in bacteria, archaea and fungi.	21.90	21.90	21.90	24.50	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.20	0.72	-4.12	134	487	2010-10-11 14:44:25	2010-10-11 15:44:25	1	7	424	0	240	486	28	104.40	32	53.33	CHANGED	ptl.p+lc+hAhhhD.ps.h.....plsGh..thRhGhD..u...llGL.l..Ps.l...GDhlshhhuhhll.h.pA.pcl....GlPppllh+MhhNlslDhll........G.hlPl..lGDlhDhhaKuNpRNhtLLccaLp	........................t..hp+lcphAhhhDpsh.....plssh...th+h..Gh-..u...l...lGL.l..Ps.l...GDhlshhluhhl.l.h.pA.pph....GlPtplhh+MlhNlslD..hll........G.hlPl..lGDlh.......DhhaKuNpRNhtllcpal.......	1	66	144	206
+13273	PF13431	TPR_17		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2YD44	Repeat	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.62	0.74	-7.98	0.74	-3.31	374	768	2012-10-11 20:01:04	2010-10-11 16:05:33	1	146	199	0	464	10633	7068	36.70	39	7.58	CHANGED	hhpculph..s..Ps.s...spshh..plu..h.h.h.t.........pp.u...p..ht...pA.tp	.................h.KSlEs..D........Ps.s.......upSaa...pLu.p.s.h.S.......................st.G......p.s..st..............................	0	367	402	433
+13274	PF13432	TPR_16		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:Q2Y5H2	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.35	0.72	-3.19	121	9987	2012-10-11 20:01:04	2010-10-11 16:24:43	1	2573	2894	10	3726	30807	9308	65.00	20	12.94	CHANGED	hthApthhptuc.hppAtphh.pphhptt...st....sspshhhhupshh.pt...sphspAh.thhpthh......ptsstss	..................................hu.thhptsc.hspAhphh.ppslptp.................Pp...............sspAhhhL..G.p..shh..pp.................G.chspAh.phhppsl.........phtPt......................................	0	1425	2531	3216
+13275	PF13433	Peripla_BP_5		Periplasmic binding protein domain	Coggill P	pcc	Jackhmmer:Q2Y8R1	Domain	This domain is found in a variety of bacterial periplasmic binding proteins.	21.10	21.10	21.10	21.10	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	364	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.90	0.70	-5.71	64	1016	2012-10-02 13:57:41	2010-10-13 14:55:12	1	18	666	4	355	8653	3387	355.80	48	85.60	CHANGED	IKVGlLaShoGohAloEpolh-sshhAIcEINssG........Glh....G..+..plEsVlhDPuSDhshaucpAccLls.p-+VsslFGCaTSsSRKuVLPVhEctsuLLF..YPspYEG...EsScNlhYT.GAuPNQQslPhlcaLhsphG.........cRhaLlGSDYVYPRpsN+Il+s.h.Lppp..Gu..c..s..lu..EpYhPl..Gp...o..-..apsllscI+....ph....t....Ps....slhSTlsGDuslsFY+thtst.....G.....ls.sp.c.hPlhuhSluEpElpul...ssp....shsGHhuAhsYFpSlcoPpNcpFlppa.+ph..a........G.s.sp..lsssshEA.uYhtlphWspAVcpA....G.os..-s...ctV+pAl.hGp....phsA...PpGt.l.p.lcs..NpHhthsstIGclpsDGQF-..llacoptsltPcPasshhst	......................................................................................................................................................................................IKVG.lLHS..L.S..G.T..M.A..I.S.E..o..s.l....p.D.sthhs...I......-....-...I..N...s...p..G.................G...V.L..........G.....+......p...l..E..s...V..l..h..D......P..A..S......s.W..P.h.F.........A..E...K.A....+pL..l..s......p.D.+.V......us.VF......G.......C.W.T.......S....s.S......R........K....u..V..L..P..V..a...E...c....h......N......u........L...L....a...............Y....P......V......Q.........Y...........E.........G..............E............S........p..........N.......V......F.......Y....T......G...........A........u........P....N.....Q.....Q....u....l......P......A........l...-.......Y....L......h...p...c..p..G..................s+..+...a.a...L...l...G...o...D....Y....V...a...P....R.T.....o.....N...+.I.l...+.s...a...L...c...sc........Gs...............c..s.....l........t.....E....s.....Y.....s.P....h.......Gp........o..D..a....p....o....Il.u....c....IK..ph.........t..............s.......sV...l..S....T..l.N..G..D....S.N.V....s....F....Y....K.p....L....t....st........G.....l.p.....u....s.....c...h....P.....V...l....u....h......S.....V......u.....E....E....E...l...p..G..I.......s....s.c.............sL..s.G...a......l.......u......A.....W.......N....Y.....F.......p.......S.......l......-..............s........P.......s......N.......c.....c.......F...l...p...p....a.....+sh....h......................G...s.....cp......VT......s....D.....P.....h....E..A...s...Y...l..u...h....a...h....W......t......p.A...VE.K.A.....................G....os........Dl..........D....c....V.pt..A.h.....h..G............p..h...s.A...........P....p....Gh...l.....p.....h...c......t...........N.....H.H...l.....p..K...s..s.h...I...G....c.l..p.s..D.G......Q...Fp...lV....a.p..o..s.pslcs.pPassh................................................................................................................................................................................................................................................................................	0	75	185	265
+13276	PF13434	K_oxygenase	L_oxygenase;	L-lysine 6-monooxygenase (NADPH-requiring)	Coggill P	pcc	Jackhmmer:Q2Y7Z9	Family	This is family of Rossmann fold oxidoreductases that catalyses the NADPH-dependent hydroxylation of lysine at the N6 position, EC:1.14.13.59.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	341	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.53	69	1152	2012-10-10 17:06:42	2010-10-13 16:42:34	1	13	829	4	434	10129	2446	319.20	29	71.40	CHANGED	claDllGIGlGPhNLuLAsLhcphs.........slsshFl-ppspFsWHsGMhLssuphQssFLpDLVThssPTS.aSFLNYL+p+.s..RLapFh.tcsahssRpEascYhpWsAspls.s...lpFuppVpslphsp...p...t........h..hpVps.....ts...ppp...phhu+plllGsG.ssPhlPss.hpsh......splhHoo.cY.Lpphsp.........tss+plsVlGuGQSAAEIah-LLpc..hs..s...hplsWloRsssahPhDposhspE.h.FoP-Yl-aFasLsp.ppRppllpppcthsasGlstsLlppIYchLYp.p.clp..u.....p....p.hpLhsppplpshpps...s...tt...shpLshcptt.ps.pp...shcsDsllLATGYch	........................................................................................................................hDhlGlGhGPh......NLul..Ashhppht......................th.pshFh-..p..p.......s......p......F..s...W...H.....s..G.M....hls...s.s..p..h.Qs.s.F.....l.pD........L.............V......o..ht.....s.Ps......s...a...SF.....l....N....YL..tp.p...s.....R.l...h...p....F.h......h........c.....p.....h......h........ssR.....p.....E.a....s......-..Y.h....p.....W.....s..A..p...p..h.....s....s..................lp.....a...u..p.p......V...p....s....lc...hst.....................p...................p........th..................ap....V.p......s.......................t.....................p.....p..p...............p..h....h..u....R........p......l..l..l.....G..s.......G.......s.....p.....P....h........l....P......p..s.....h...p...t..h.....................t...p....l....h.....H...u...o.....p...a.......ht.p...t..t...............................thpsc+lsVlG.u.G.QSAAE...l...hh...sL...hpp.......hs..t....................hpl..s..h.l.s..R..p....s.......s....a....t....s.....h......-....p.....o...........h...s...p...E.......h......F....s.........P...-......as..c...........h......F....a......s....h..sp.....p.t..R....p.p................ll.t.p....p.....+.......h.......h.s...u......l..s....c.h......l.....t...p.....I...Yc.....h.l...Yp..p....p....lh.t............................p.....p..hplh.s...s.p.p.l......pshp....tp..............s...........t.......th......p.L........t......h.p............p.....t.....................p......t.........t.........p................tp..h.csDsl.l..hATGYp.....................................................................................................................................................	0	99	242	354
+13277	PF13435	Cytochrome_C554		Cytochrome c554 and c-prime	Coggill P	pcc	Jackhmmer:Q2YA34	Family	This family is a tetra-haem cytochrome involved in the oxidation of ammonia. It is found in both phototrophic and denitrifying bacteria.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.34	0.71	-12.51	0.71	-4.09	93	858	2012-10-01 23:37:15	2010-10-13 17:17:09	1	116	351	4	437	1110	218	122.30	16	25.29	CHANGED	sCh.sCHsp..tt.ppatp.....ot.Htp.hhpsh.t.....ttt..................h...t...........t.sp..spCs.uCHs.sh.thp.s....tsh.....sht......p.........h..........tsl.sChsCH...ssss.sa...spts.ss.sst............h.t..............................hsts.stsstpsCusCHt	......................................................................................t.....................................................................................ptt..ttCh.pCHs..ss.....htp....s......t.sh........st.s..............p.........tt......................................tsl.sCtsCH.......uss...u...pa........tph.s.t.t..t....................................................................................ht......ht.ptp.C.h.tCH..............................................	0	157	293	384
+13278	PF13436	Gly-zipper_OmpA		Glycine-zipper containing OmpA-like membrane domain	Coggill P	pcc	Jackhmmer:Q2YCQ8	Family	\N	28.90	28.90	28.90	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.80	0.71	-4.44	34	349	2012-10-03 03:18:43	2010-10-14 11:39:32	1	7	288	0	122	1054	136	99.20	26	65.73	CHANGED	uCAshPsGPs......hshPusscs..hppFp..tDcttCRpaAtpps...ss..psp.....pss......p.sussu.uslGsu.lGA....usGA.shGs.....upG.AulGA..usGhLsGuAuGusuuphtshtsQ.tpY-suYhQCMhu+	.......................................................................................................................tsp.........psp.........................ppss..su.ussGAA.lGA....ssGu..shGu.......upG....AshGA..uhGuls.Gu.......hs.....G.......u....s.......ts.....p...p.....t.t..........t.....................................................	0	29	74	102
+13279	PF13437	HlyD_3		HlyD family secretion protein	Coggill P	pcc	Jackhmmer:Q2Y7Y5	Family	This is a family of largely bacterial haemolysin translocator HlyD proteins.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.48	0.72	-3.69	147	4655	2012-10-02 20:27:15	2010-10-14 13:36:12	1	49	2429	0	1181	25718	5084	112.10	18	29.22	CHANGED	tlpAPhsGhl.p..t..h..s...h..p....G.ph...lp.s.Gps....lh..p....lhs.........s...p.....h.t.lcsh.l.sspphstl............Gpplpl.pht....s.hst....p...l...pGplppl..u..s......ss....s.......p....psp.....s..ht.....h.....ph..plsss........................thtlpsG	...........................................lpuPhsGh..l..t...p........h..p..............s...p..............G...ph........l......s.....s.......G....p..s.................l.h....p........................l.hs....................h.....s..p................l.h..lp..sh..l.....s.s.....p.........c....l....s.t.lc.....................G.p..p.........l....p....l....phs............s.htth....s......l................pG.p..lpp..I...u..s................ss........s..........................p.......ppp................h..h............s.....ph..phpt..................................................................................................................	0	360	721	990
+13280	PF13438	DUF4113		Domain of unknown function (DUF4113)	Coggill P	pcc	Jackhmmer:Q2Y7D7	Domain	Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, Pfam:PF00817.	24.00	24.00	24.30	25.40	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.38	0.72	-4.37	197	1492	2010-10-14 15:22:47	2010-10-14 16:22:47	1	11	959	0	244	1129	1436	51.00	46	13.70	CHANGED	sppLMpslDplNp+aG+uslhhAu..p.G...h.p........p..........sWpM+RchhSPpYTTcWs-LPhl	....................sppLMpslDplNt+pG+GslaFAu..p.G...h..p..........p..........pWpMKRphLSPpYTTRas-L.hl................	0	65	133	204
+13281	PF13439	Glyco_transf_4		Glycosyltransferase Family 4	Coggill P	pcc	Jackhmmer:Q2Y6X7	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.96	0.71	-4.55	52	6671	2012-10-03 16:42:30	2010-10-14 16:40:50	1	54	3442	22	2039	11319	3388	166.90	15	42.72	CHANGED	lllsspphtp.huGsEhhsh-LApthtp.pGapVplh...usphsp.htpp........................hhhthshhhthtphlpph..chDll..+.p.........................hhhshHssh.....................h.......hp.h.hhhhthh....h.tsctllAlSptstcplhp.hs....lsp....pclpVl.Nul-tphFp	............................................................................................................................................h.................hu.G..s.t..p..h.hhpltp..t....L....t.p....p....G...a...p....l...h.lh.................s...t.......t..t................................................................th..........................................h.........t...........t.........h....h...........h......t.......h..........h............h........h.......h...........p.......h.......t.........p.....h.......h....c...ph..............ph.D.ll..........Hh.p..t...........h......s...h...h....h...s..h.hthh.................................hph..h.l..t..o....h.Hshh....................................................................................h...h.....t........h..h...t........h....h..h....thh.............hp...p.sc..t...l..l...s.....l.S.p...h...h..t..c.p..lhp...hs.............h...............pplp.l.l......s....Gl-.t.........................................................................................................	0	677	1353	1746
+13282	PF13440	Polysacc_synt_3		Polysaccharide biosynthesis protein	Coggill P	pcc	Jackhmmer:Q2YCG5	Family	\N	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.76	0.70	-4.92	52	1715	2012-10-02 21:24:20	2010-10-21 10:27:40	1	14	1385	0	471	5839	872	248.50	15	56.48	CHANGED	tssshhhtlhlu+hlshpshGh.athshshhs.lhhhl.s...th.Gh..pssh.ht....t..s.tstp.p..htsh.hthsh..hs..shlluhshshh..hlsh...hh..t.s..thh.hh.hluhhhhshhhpthhpthhhsttchth.sshhshlhshhh.hhshlhh.hhhth...slhshhhs..hshuuhlshlhhh.h....htt...hc.ht.hp........shth.h...c.h.h.p.puhhhshtsh...hshhs.hphsh.hl.lsh.h.us..stlGhaps.st.hlhth.hs.lhhtsltphhhPphu.p.t	......................................................................................................................h...thhhhhhls.+.h.h...s...stt.h...Gh...hs..h...h....hs...hh...h..h.h....l...h.....th...th......p......h...ht...............tt...tstp...p..........ht.p....h....h....p....h..s.h........hh........sh.l..h....h....l...s....h....h.....h....h......h.............h....l.sh................hh..........s....s.....t.....p.....h..........h.........................h...........h..........h.....h..........h......s......h...h...h....h...h....h...s.....h.....h....s....h...h...p.....s.......h....h......p...t......t....p........+.......h...ph.....hu.......h.......p......h.....h..p.....s....hh...t.....h..h..st...l.hh..hh.hsh..................sh.h.u.......h..l...lu..........h....h.........h....u...s...l....h......u.....h.........h....h...h..h..h................hht...........tp..h.p...hp..............................ph.ph..h.........c...h...h....p...p....s....h....h....h.......h..h....tsh.................h.t.h.h....t.....tp.....h.........s......t.....h..........l....l.........s.....hh....h...us.............ss......s.G.....h...as.....h....s....h....ph....h.s.h...hs....hhsts.l.sp.hhhsph...h..............................................................................................................	0	144	297	385
+13283	PF13441	Gly-zipper_YMGG		YMGG-like Gly-zipper	Coggill P	pcc	Jackhmmer:Q2YAQ0	Domain	\N	27.60	27.60	27.60	27.60	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.47	0.72	-4.44	284	420	2012-10-03 03:18:43	2010-10-21 10:38:44	1	7	388	0	100	1126	106	43.70	46	28.65	CHANGED	sss..stGAulG....A.usGAs....lGuhsG........tu.s..p....G...................A....h.lGAusG....ussGu.......shGs........t	................psstGuhlGAusGAlhGshsG............ss+....G........................A.AlGAGlGAlsGhh.....................	0	21	55	80
+13284	PF13442	Cytochrome_CBB3		Cytochrome C oxidase, cbb3-type, subunit III 	Coggill P	pcc	Jackhmmer:Q2Y8Z1	Domain	\N	27.00	22.00	27.00	22.00	26.90	21.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.80	0.72	-3.82	488	9400	2012-10-03 10:02:11	2010-10-21 13:26:28	1	190	2200	132	3123	13490	4902	79.30	23	30.40	CHANGED	sss.psGpplY.p.p....sCt.s.CH.u......sG......ss.....u............sslt.......sp...shs........s.............cplhp.......hsh..p.G.......t.....s.....u...MP....shs.t......p.ho-c-lptlssal	............................t..htpGppla..t.p........sCu..s.CH..u..............ss......ut.....G.............................................PsLt......................ss.......sht......................................................................pplhp.................hlh.......p...G........................t.............s..............s.......MP..............uas.t..........tL.s.-.pc..ltslssYl......................................................................	0	889	1958	2631
+13285	PF13443	HTH_26		Cro/C1-type HTH DNA-binding domain	Coggill P	pcc	Jackhmmer:Q2Y718	Domain	This is a helix-turn-helix domain that probably binds to DNA.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.74	0.72	-3.77	196	4823	2012-10-04 14:01:12	2010-10-21 13:31:50	1	44	2292	4	901	17516	1639	60.70	23	55.90	CHANGED	+.Lpph..htc+....ph....shpcL.....t.....c......ts......G.....lop..sslscLtp..s.p.....p.tlsh..ssLpplCphLsC.p.suD.ll....chh..s-	....................................lphh.htc..+........ph....ohpcL.....u........c.......ps.........G..........lop.......sslsp.....l.tp.........s..c................p...s.l.p......h...ssL.p..p.I......C.c.hL......s....s..p....s-.lh.....ph.................................	0	334	628	760
+13286	PF13444	Acetyltransf_5		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:Q2Y7M2	Domain	This family contains proteins with N-acetyltransferase functions.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.61	0.72	-3.44	244	1571	2012-10-02 22:59:21	2010-10-21 13:46:37	1	11	1299	0	478	1970	489	102.60	30	27.02	CHANGED	LRa.pVFtpEhsusspt......t.hD...hDpFD...shscHLllh....-.ppp...............lVGsYR.lhtsstst....th..ts.hYops.F.....c.h.stlts..hhs...phlElGRSsVpscYRsttshhhLWt	..........................LR.psFtpph....suphps.........t..hD..hDpaD....p.h.s.pHLllh.....Dpsp...................c...lVGsYR..lhhssphh....................th.....ss..hYops.F..c...h..st.hht.......hhs...phlElGRosVp..scYRss.t.sh.hLh........................................................................	0	133	304	401
+13287	PF13445	zf-RING_UBOX	zf-RING_LisH;	RING-type zinc-finger	Wood V, Coggill P	pcc	Pfam-B_49 (release 24.0)	Domain	This zinc-finger is a typical RING-type of plant ubiquitin ligases [1].	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.44	0.72	-4.24	80	584	2012-10-03 15:03:13	2010-10-22 16:12:06	1	39	268	1	422	2209	29	41.40	40	9.31	CHANGED	CPls+-....ss.tp.......Ph.h...Ls.CGHlls+pslp+lsp.......tt.................p.....hKCP	...............CPls+E.....osp.pNs............Ph.h....Ls.CGHsls.+c.sLp+Lhp..............ss......................p......h+CP............................	0	166	244	345
+13288	PF13446	RPT		A repeated domain in UCH-protein	Wood V, Coggill P	pcc	Pfam-B_2127 (release 24.0)	Domain	This is a repeated domain found in de-ubiquitinating proteins. It's exact function is not known although it is likely to be involved in the binding of the Ubps in the complex with Rsp5 and Rup1.	24.10	11.40	24.20	11.40	23.80	11.30	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.82	0.72	-4.56	66	317	2010-10-22 16:03:35	2010-10-22 17:03:35	1	11	124	0	248	350	8	60.80	23	12.16	CHANGED	hhshppAhphLpl.ccsssD-hllosaphKls........-sP.s..phchh++ALphIAcpRpSth..LhpFLps	.......................shtpAhph..L....t..l...s......p......s....s....s.D-..hllssaptphp..........ssP..s...phphhpcALphIAptRpSth..Lhphl..............	0	59	132	216
+13289	PF13447	Multi-haem_cyto		Seven times multi-haem cytochrome CxxCH	Coggill P	pcc	Jackhmmer:Q2YA36	Domain	This domain carries up to seven CxxCH repeated sequence motifs, characteristic of multi-haem cytochromes.	21.90	16.20	21.90	16.20	21.80	16.10	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.52	0.70	-5.33	11	1428	2012-10-01 23:37:15	2010-10-25 16:31:19	1	16	119	2	112	1635	47	181.40	54	67.74	CHANGED	ppVGCIDCHu.....slst.pphpHppc.......LtMPstssCGsCHlppFAE+EuE+cs......W.........Pptp.........Ws.G+PSHulsacA.NV.EsuhaAuMspREVApGCsMCHsp.QN+CDuCHTRHpFSsAEARcPpACusCHsGlDHNEaEsYhhSKHGslapsptc.pWsapsPLK-Ah.pcGG.TAPTCssCHMEacG.-aoHN.lsRKlRWu.sP.sPtIA-sl..sp.WhEtRh-uWlsTCspCHSspFA+saL-thDpGphpGlshhpEAcplltsLYcDGLLsGQpTNRP	..............................ss....................................................................................................................................................................................................................................................................................tGCT...F.C..HT...........s.....p............p........+.........Cso.CH..p.RH...pF...s.s.t.......AR+...s...E.pCps.CH.h.G........KD........HRDWE..AYDISlHGs.......VYQlN..K........a.D...ashp....ctL.u.D.A.D...YVGPTCQYCH....M.....R.....GG.....H..............HN.VQR.huTV.................Y............TS.....M.....GM..S...........A...D..RG..................A.Pl...WpEKR..DpWsSVCDDCHSPRFAREpLQAMDEAsK.D.AG.LK.Y.pE.TFKVAEsLhhDGhh-PMPKD..Ls...........................................	0	45	90	107
+13290	PF13448	DUF4114		Domain of unknown function (DUF4114)	Coggill P	pcc	Jackhmmer:C1ZAY0	Family	This is a repeated domain that is found towards the C-terminal of many different types of bacterial proteins. There are highly conserved glutamate and aspartate residues suggesting that this domain might carry enzymic activity.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.23	0.72	-3.16	74	320	2010-10-25 15:42:29	2010-10-25 16:42:29	1	61	151	0	82	297	55	84.00	22	9.76	CHANGED	phsuG...splua....hLhssuhssthht.............................h...ao.sshN.............ss....hp.....phtshttsst...h......lGaEDhh.....uD....p..DaNDllFtlphss	..................................................................................h.tG.tluhhl.hssuhttthht...................................................h.aohtshN............................ss............hp.............ph.tshtsss......hh..............luFEDhh.s..........uD.............t....DaNDllhtlph.........	0	26	59	81
+13291	PF13449	Phytase-like		Esterase-like activity of phytase	Coggill P	pcc	Jackhmmer:Q2Y944	Domain	This is a repeated domain that carries several highly conserved Glu and Asp residues indicating the likelihood that the domain incorporates the enzymic activity of the PLC-like phospho-diesterase part of the proteins. 	21.30	21.30	21.40	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-12.38	0.70	-5.17	51	1288	2012-10-05 17:30:43	2010-10-25 17:12:27	1	51	942	0	459	1415	255	314.60	19	66.08	CHANGED	phlGp........hslssshthsu.........sthGGlSGlsass.psstaaslSDcts....sssRaYshplsh....tst..thsslphtshssLpcss..................Gpsa...........h.DsEulth..sssslaluSEGc.....tt.h...Phl..hchs.hs.Gph.hpch.sl.Psthh.t.t.................pGhcsNhuhEuLolss-...Gp......hLasAsEss......LhpDustsp....tt.......sRllpachts.G..ts....htpahY.h-sh...........stsGlo-llAlsspt..hLslERu...au.u...................hGtsh+laplsls.s..upsssshsslt....s....lsslpKpLlh-htp.......s.h...lDNlEGhshGshh.-GppoLlllSDNNF......ss.t.QpTphlshplp	...........................................................................................................................................h.h................s...........htu.h.Sulhh............t........t......s............h....h.sl..sDps...................................t....h.hhh.hph............................t.sth.ph.h..p.h....h...lp.css...................................................................Gt.sh.......................................DsEulsh................ss......u......s......halusEhs...................Phl....hchs.....ts...Gph....h...t.......h.....s....h...Pssh..................................................hthpp..stGaE...ulshs.s..-...Gp.........hLa.shh....pss....................l.h..p.cs.t....t...................hRllpa...sht...s.....t.............................htta..h..Y.h-t......................tshsl.u-hshlsspp...hlllE..Rs....t.s......................................uhhp+.l.ac....ls...ls..t.....t........................h...........t.s........h..tt....t................t..............h.h.hptp...l..h.s.h....................................s..h......h-phEGl....sl.............................................s......s........p.......p..........lhlhs.Dssa.......................t.s.hh..............................................................................................................................................	0	109	269	375
+13292	PF13450	NAD_binding_8		NAD(P)-binding Rossmann-like domain	Coggill P	pcc	Jackhmmer:D2BHP8	Domain	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.46	0.72	-3.95	465	10693	2012-10-10 17:06:42	2010-10-25 17:56:16	1	305	3705	149	4167	53665	24260	63.30	26	12.65	CHANGED	IVGu....Glu..GhshA.th..h..s.....c.....p.....s..h....c..l..hlh-...p.c.sc.lG..Gps.h.sh...ph.......p..u........hhh.c.hG.s+.ha.ts.......t........tt...hh.c..hh...cp.l	.................llGuG...hu..G.LssA...hh...L..s..........................c.............p..........G...h.......c.....V...hl...h.E............c....p....s.......p.....h.....G.......G.p.h....h....sh....th.........................t.................h.p..hs...............................................h.......................................................................	0	1314	2568	3528
+13293	PF13451	zf-trcl		Probable zinc-binding domain	Coggill P	pcc	Jackhmmer:D2BIP7	Domain	This is a probable zinc-binding domain with two CxxC sequence motifs, found in various families of bacteria.	21.50	21.50	21.50	22.20	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-8.73	0.72	-4.33	91	388	2010-10-25 17:00:03	2010-10-25 18:00:03	1	9	215	0	117	275	17	49.10	57	50.87	CHANGED	pDKsLsCKDCGpEFVFTsGEQEFY.tE...KG.F...p.NEPsRCssCRcARKpppss	...tDKsLsCKDCGpEFVFTsGEQ..EFYtE...KG.F...cNEPsRC.sCRcARKpppp..............	0	65	108	113
+13294	PF13452	MaoC_dehydrat_N	zf-MaoC;	N-terminal half of MaoC dehydratase	Coggill P	pcc	Jackhmmer:D2BH16	Domain	It is clear from the structures of bacterial members of MaoC dehydratase, Pfam:PF01575, that the full-length functional dehydratase enzyme is made up of two structures that dimerise to form a whole. Divergence of the N- and C- monomers in higher eukaryotes has led to two distinct domains, this one and MaoC_dehydratas. However, in order to function as an enzyme both are required together.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.39	0.71	-4.37	39	2537	2012-10-02 20:54:35	2010-10-25 18:06:56	1	31	1010	26	1023	4405	1494	127.80	17	29.40	CHANGED	shlGpph..ss.hp..hplppuplRtFAcAh..Gp......ss..Ph.YhDptsApts.ta.sl.APPTF.hh.sls.....h.....ss.......hh.....ptl...s..ls..h....tplLHG-.Qpapa...cp...s.lhsGDplshpspls-lh-.Kps...Gs.h.calshcopssspcGchVush	..............................................................................t....................h...hsttplh.ash...ul...ss..............tt...s....hhs.t.............................s.h.h.s....P...s.o....a..sh..l.hs....................h..........ts..............................hh..........tl.........s....hs....h..................hpl..l...H..s...s.....p.phph............t+...P.....l.h...s...G.-p...l.psp.sp.l.ss.lhs.+.t.....Gp...s..sh....ls.hc.sp.h.p..p.t.p.G.p.lh..h...................................................................................	0	248	602	865
+13295	PF13453	zf-TFIIB		Transcription factor zinc-finger	Coggill P	pcc	Jackhmmer:D2BJR6	Domain	\N	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.48	0.72	-4.76	126	674	2012-10-03 10:42:43	2010-10-26 09:24:28	1	7	520	0	270	585	125	41.10	44	38.76	CHANGED	pCP..pC.p.s.s.hp.....hhcp..............pu.lplDhCs.pCcGlWL.DpGEL-+llpp	..............CP..hC.ps.s.lh.........hs-+..............pu.lcIDh..Cs.pC+GlWL.D+GEL-+llp.........	0	84	174	240
+13296	PF13454	NAD_binding_9		FAD-NAD(P)-binding	Coggill P	pcc	Jackhmmer:C2D2T2	Domain	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.08	0.71	-4.45	180	1586	2012-10-10 17:06:42	2010-10-26 10:52:14	1	24	1273	0	358	3901	1444	156.50	25	30.28	CHANGED	AIlGuGspGlsshtpLhpph.......t..ts....lplplh.-s..t.sh..G.G...tsaps..s..p..spthlhNssusph.ohhscps.............ssahcWhp.....spt......................ths.s.ps..assRtlaGcYLpthhpphhp.ph...st.th...plph.h.p...s.cls...s.lpt...ps......ss....h...h.l...hh....s.su..p..s...h..tsDtV.lLAsGps	.............................................................AIlGuGssGlhshh..pLlpp......................tss......lsls...la.-p.....s...th....G.........G.........hsat.s....p.....p....st.h....L.h...N..h..s..u.t.p..h..s.h.h.sp..........................................................ssa..h.cW.hppppt..........................................................t..sh..p..s..p..p.......a..h.P.R.......h..l.......a..G.cY.h....c....p...h.........h..pth......hp....ph......p.hh.......p.l.t.....h.h....p......s..plh......s...l..p.......ss...................ss.........h.....hl.......th................s.ss.....t......s..............h...shDhl.lLAsGp.h......................................................................................................................	0	84	201	290
+13297	PF13455	MUG113		Meiotically up-regulated gene 113	Wood V, Coggill P	pcc	Pfam-B_48720 (release 24.0)	Family	This is a family of fungal proteins found to be up-regulated in meiosis.	22.30	22.30	22.40	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.99	0.72	-3.53	212	101	2012-10-01 19:55:08	2010-10-26 13:41:55	1	2	86	0	70	797	308	100.00	30	25.08	CHANGED	hKIGhTs...ss.pcR...lpphppts......shphpllthh.ht................................sstclEphlHpphps..tRlpt..................EaFc....lsh.....pplpp................s.......lcch	..................................LKIGRus....NV.p+R.lspWpcQC........spplpll+ha.hhs.p.t.............................................................phsscs++lERLlHlELss...............hthpt.....t.Ct.tC....s+.......pH.....pEaFc.lps.........pphtt................l...l............................................................................	0	20	39	58
+13298	PF13456	RVT_3		Reverse transcriptase-like	Coggill P	pcc	Jackhmmer:D2BGL4	Domain	This domain is found in plants and appears to be part of a retrotransposon.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-9.62	0.72	-4.20	89	3907	2012-10-03 01:22:09	2010-10-26 15:56:17	1	208	854	5	1534	3767	350	81.20	25	12.10	CHANGED	s.h..........AEhhAl..ltGLphAhphGhp.+lhlpuDuphllptlpsp...hpsps.phstllpclcplhpp.Fpphplp+lsRcsNpsAcsLAp..hutpt	......................................s.p.AEhtul...lhuL.p....h..A.h......p...h........s...h.......p....p........l..h.l...hs.D.SplVl...p..pl...p.tp................hpsp....s...p...ht........h..h..pp....l..c..p..hhp....p....F..p....t....h......p..l....p....al.............R....p....p....N..ph....ActLAp.u...t.....................................	0	197	508	925
+13299	PF13457	SH3_8		SH3-like domain	Coggill P	pcc	Jackhmmer:C2D335	Domain	\N	21.00	5.00	21.00	5.00	20.90	4.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.66	0.72	-3.82	69	1627	2012-10-02 18:48:24	2010-10-26 17:18:41	1	78	162	3	111	1462	0	74.30	26	36.50	CHANGED	ss.cslshpuplp..pspsculas.pshthsuspplss...ups....Ysspp...lplh.ccApTs+........u...o......ahph...........ph....supslGWlDpcAhs	...................................................pcslshhshVp....s..ssssu..las.t..Phtss.usp.p.......sst...........lss........Yps+s...lpl...+cApsst..................................s..s........WYpl..........ph.....sspsIGWlcscsh...........................	3	37	65	98
+13300	PF13458	Peripla_BP_6		Periplasmic binding protein	Bateman A	agb	Jackhmmer:A3PL33	Family	This family includes a diverse range of periplasmic binding proteins.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	343	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.94	0.70	-5.09	259	10778	2012-10-02 13:57:41	2010-10-27 11:15:08	1	73	2751	52	3781	13919	6511	334.70	19	81.74	CHANGED	sl+lGllhsh.o...Gsh...u...ss..upshhsusphulcphN.t.s.G...............Glt....G..c.....p..lchl.ht.D.sts.ss.stssptucchlp..p...cp..Vts.lh.sshsossstul.ts..hh.pp...ps.h..........hl....s.......ss..........t.....hs........s....t....p.s......ss.t...ha..hh.s....h......ss.t.tp..st......shspa............h......h......p......p.h........G........sp......c.hh.hl.s..ss..hshu.psh.t.p...sh..pph.hp....tt.Gsp..ll.............sp....hhhs...h..ss....s-....h..ss....hltp.lps..u....tsD..................s....lhsss.susssss.hhcth..p.p....t.G.....ls........t..h.hh....u.hs..ht.psp..l..tsh.......us....ts...s.p.......G.....h.....hhs.ss....ah......s......h.....s..s....st..........sptahppa..pp........t....h.............s.....p..t............s.s.t.htt...s...uYhus....thh....h.pAl.............cp....A.........G........s...s..s.....sps..........l....h................ps.l.c.s..hs...h.....s..........s.......s.h...........u.t..hth.........h...s.s.....s.pp..s....h........p.s...hh...lsp.lp......ts..u...p	..............................................................................................................l+lGhhhs.h..o........G.sh.......A....th....G.p.t....h.pGh.p.h...A..l.cc.lNt..t..G.........................slt..........G...c.........p....l.pll...hh..D.....s................t......s.....c............s....p.p........u......s....s...s....s....p.c.....l...l..s...........................cp....lt...h..l.l.G....s....h..s.S.u..s...s.h.s.s..ss.....l.h...pc.......t.t...l.......................shls...........su..................................s......ss.............s......p.........ps....t..t...h.....ha....+h..s........s....................ss....s...tp....ut................s.h.up...a.......................................h.............h..........c........p..h........s.............sc..........+.l.u..ll..t....ss.....ss...a.....G...pu.h...t..p..................sh...pps..h.c........t...t...G.hp........ll............................t.p......t.th..s...........h....ss........pD..........a.....s.u...........h..l...s....p.....l..p..s.......t.................s..s.D...................................................................s.........l.h.h...s.s.......h...t...s...p...s..s........hl.+....p.h....p.p.....h....G............hp...............s...........h..hh........uss......hs...s..s...p....h...ts.h..............................us........ts......s..p.........................G..........h...............hh.s..ts........hh........s...............p...s........st..............................................sp..t..a....h..p..t...a....ct.....................p....h.............................................................s....p...........................s...s..h....h..sh............h....uYsus.......hh.l....h.pA.l......................................pp...s..........................u........s....h....s............stt..........................l.h....................................................p.s...l.p.s.....hp....h.....p............s........s.h.............G.......h.t..h............t....t.p......s..t......h......................h.h..h.h.p.h.......t.............................................................................................................................................................................	0	935	2299	3103
+13301	PF13459	Fer4_15		4Fe-4S single cluster domain	Coggill P	pcc	Jackhmmer:B0SHL0 	Domain	\N	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.71	0.72	-3.41	122	1717	2012-10-03 08:56:43	2010-10-27 11:35:52	1	33	874	0	647	2723	504	59.90	29	46.40	CHANGED	lhVD.c..spClGstt...Csths.....P.csFph-.s.c.u.hupsh...............h.................hssc.ppphp.cA.hcsCPsssIpl	........lhlD.p..spCh.Gsuh......Chths........P....-.l...Fp.hc.-.-..G..hstlh...........................................h.ss.s.tp.ppsp..cA..scsCPspAIp..............................................................	1	174	451	575
+13302	PF13460	NAD_binding_10		NADH(P)-binding 	Coggill P	pcc	Jackhmmer:C2D4U5	Domain	\N	23.50	23.50	23.50	23.50	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.94	0.71	-4.28	74	14495	2012-10-10 17:06:42	2010-10-27 11:37:19	1	78	3768	30	5105	51820	16534	186.90	17	65.92	CHANGED	IsllGAsGpsGptlspchhpcG....hpVpuhs...Rs.ss....ths..........thphlphDl..hsh...tthspslp...G..hDsllssh......ush...tt...........c........tp..s..sp....pllcshp.t...s.s..sp.+.ll...l..l.uusu...hhp.....stpth..............h............h.h....ttt..t.ts.....-.....chl....p..s.s..sl.sWThlpPut.hhps.......t...sp....phph.....hts...........ss.....s.t.....st.....shlshpDlApshl-tlps	......................................................................................................................lhlhGA..o...G....h...l..G...p......t....l...s......p.......p......L.........h......p........p......G..............t...p..V.....t......u.....h....s.......................R.....p.....s.p...............p...htt............................ts...h....p......h........h.........t........s........D..........l......p.s......................t.s....l.......t.......p.......s.......l.......p...........s...............h.......D.............s........l.......l...h..sh....................ss.h..tt........................................................-.................................hp.s....sp..........p..l.....h....p...u.......h....p....t...............s...s........lp.......+......h..l.............h...........l...Su...h.u................s...t..................p.t...s.........................................................................h..h........ps.c.......t....ts..........-............ph.l............................p....p....s.......sh.....s....h......s....l....l...R.....s..u......h....l..hss..................t.....tt.............hth......hht..............................................................h...........t.l...t.h...t...D...hAthhht.h..t...................................................................................................................................................................................................	1	1558	3201	4341
+13303	PF13461	C-term_anchor		Cell-wall surface anchor repeat	Coggill P	pcc	Jackhmmer:C2CZF8	Repeat	\N	27.00	27.00	27.30	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.04	0.72	-3.50	178	2550	2012-10-02 15:23:12	2010-10-27 14:32:45	1	182	317	1	148	2314	6	59.40	35	18.55	CHANGED	YlDp.sGpp.ls...ssps..loGp..lGcsY....so.....psc....sIsG.....Y..plsps.....sssts.GsFs.pss.psVsYV..Y	........................YhDp.sG..pp.ls....ssps....loGp........lG-sY....so..................psc.......sIsG.................Y...sLsps................ssNss..GsFs..sss..poVsYVY................	0	51	84	132
+13304	PF13462	Thioredoxin_4		Thioredoxin	Coggill P	pcc	Jackhmmer:B0SES9	Domain	\N	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.08	0.71	-4.23	52	3857	2012-10-03 14:45:55	2010-10-27 15:14:37	1	30	2252	39	1197	5536	2874	166.60	17	66.73	CHANGED	ss....s..shh.lGstcAslsllEYsshsCPaCsp.app.p.s.h..p.lhpc.YlcsG..Klpalh+ph....hs.c.s....lhAuhh...ucs.stp...s...phF.h.hhpphhhpp....ppt....hsps.........pt........hs........tp............sssh.....t.cp.h.t.sh.pss.p.hpshl.t.t.pp.p.u.cps.slp.sTPohhl..sGch..h......s.shsh-chpthI-p	.......................................................................................................................................ts........G......s.u.....l.sllt.ahDapCPa.C....t....p....hp............t..p....l.....t.....p....l..h....c...p......h..........s..s........c.l...p..h..h..h+..ph................sh......sps..............uht.A.u..ts..............u.ts...s..tpp...........s.........pha....h.hh..c...p...h...l....h..p.p............p.pt.....hspt................pp............hs...........tp..............................................................tshs......h.pp..hpp...sh......ps....t....p....h......p..p.t..l....p......p......s...........t.p...........h........u.......p..........p...........h.....s....l..........p......u..........TP.o..h..h..l.........sGph.....h.........t..t........s.....p.th.thl........................................................................................................................	0	389	766	1022
+13305	PF13463	HTH_27		Winged helix DNA-binding domain	Coggill P	pcc	Jackhmmer:D2BJI8	Domain	\N	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-8.92	0.72	-3.65	61	2080	2012-10-04 14:01:12	2010-10-27 15:25:49	1	20	1390	11	608	21196	2353	65.80	23	40.16	CHANGED	lot.phhl.Lppls........ttpptph.sclsthhshc.psshs......tslccLhct..Ghl..t..tp..spt.....thhplTscG	..................................................phhl..L.h.tls...............tppthoh..sc....ls.p.t.h....s.lp..pssls......pslcpLhcp........Ghl.....ppp.ts.....p.D+Rp...........thlpLTspG........................	0	154	358	487
+13306	PF13464	DUF4115		Domain of unknown function (DUF4115)	Bateman A	agb	Jackhmmer:A3PK73	Domain	This short domain is often found at the C-terminus of proteins containing a helix-turn-helix domain. The function of this domain is unknown.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.34	0.72	-4.33	73	1846	2010-10-27 16:37:37	2010-10-27 17:37:37	1	11	1803	0	409	1357	405	75.40	29	23.46	CHANGED	ltlhss.tsuWlpVpsADG...pllhpslh...psG-shsl....ssptPhplplGsuu.ulhhslsGpthss.ushup.spsspLohs	...................lshshs..uc.sWlp.Vp....D..u.s.G...+pLh....s..G.hh...+tG..p..s.hsl....supsPhc.l.plGssu.uV.plph.sG.cslcl...uthhp...sp.sschsh.t....................	0	117	257	347
+13307	PF13465	zf-H2C2_2		Zinc-finger double domain	Coggill P	pcc	Jackhmmer:D2BGQ7	Domain	\N	22.50	20.00	22.50	20.00	22.40	19.90	hmmbuild  -o /dev/null HMM SEED	26	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.11	0.73	-7.56	0.73	-3.41	163	227898	2012-10-03 11:22:52	2010-10-27 17:41:20	1	6697	1851	312	138033	194266	376	25.80	50	27.05	CHANGED	pLppH...h...p.p.Hp.......sp.c.....s....a.......pCt..h..Cs..tpapp	......................LtpH.......p.............R..l.HT........................GE.K.....................P.....Y...........................cCp.......p..CG...KuFs................	0	21562	34039	60664
+13308	PF13466	STAS_2		STAS domain	Bateman A	agb	Jackhmmer:A3PG87	Domain	The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [1].	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.33	0.72	-3.95	89	3458	2012-10-02 18:52:36	2010-10-28 17:48:09	1	38	1847	0	1117	4550	627	79.20	22	51.70	CHANGED	LpLsGplsh.psss.s.Lhptltt..hl........ts..s.....pl.plDhutlpphDsuulslLhphtptstt.ps.pplpl.ps.sss.t.lt.plhplhGls	......................................lsGclDh...ssss...s..lh.pthtp.....hh...............pt..s.....tl.sl..DLuplshlDouGlulLlph.hcp......s...p..p......pG....t.plpl..t.s..s.ss..p.lt..plhplhsl.............................	0	371	742	971
+13309	PF13467	RHH_4		Ribbon-helix-helix domain	Bateman A	agb	Jackhmmer:A3PHV5	Domain	This short bacterial protein contains a ribbon-helix-helix domain that is likely to be DNA-binding.	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.08	0.72	-4.09	57	610	2012-10-02 18:44:02	2010-10-29 13:14:09	1	3	438	4	200	495	214	68.70	37	66.55	CHANGED	t.hpR.......SlplsGHpTSlpLEstFWshLc-lAppcuholspLlucl.....Dtpp.......................cs.NLuSslRlhsLpalp	..............t..hpRSlplcGtsTSlpLEshFWphLc-IAspcshol.spLlucl.........Dtp+.......t..............ch..NhuShLRltsLpal.t.......................	0	50	109	147
+13310	PF13468	Glyoxalase_3		Glyoxalase-like domain	Bateman A	agb	Jackhmmer:A3PMH5	Domain	This domain is related to the Glyoxalase domain Pfam:PF00903.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.42	0.71	-4.36	115	1009	2012-10-02 15:00:03	2010-10-29 13:27:31	1	8	863	2	301	1880	849	182.90	23	72.75	CHANGED	lDHlllssp..sLspussth.p..pLGhshs..........sGGpHs.th..........GTpNtLlhh..u..s.....s.YlEll.u...l.c....Ppts.......................ss....t....ts..p.h.athc......................php.....p......s..sultshsh........cs...sDl..sssttpht..........p.t.G...........p.h..phst............sp.....lpWchs..hhts..sthsh...........tshhPhh....IpWtss....c.s.............p.......ts.ss.shslppltl...sss..cs...stht.thh......stlh	...........................................................hDHllhhsp.....sL-pshph...........h.p..thGh...p..ht......................s..G..GtH.s..th...................GT.tN..p..L.h....h...h....s....p................s..Y..lEll.s....l..c...sspp..........................s.....t.ts..p.hhshp........................hhp...t......stGhtshsl..............cs.....sDl..pshppchp...........p.pult.....................st.h..ph-t...............tp......lcWphh...hhts..tt..t........................phthPFh...I.pWpps....ct..................tp.......a...ss.shslpslhht.sp..p....ppshphh....h..........................................................................................................	0	84	176	244
+13311	PF13469	Sulfotransfer_3		Sulfotransferase family	Bateman A	agb	Jackhmmer:A3PS36	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.13	0.71	-12.53	0.71	-3.29	403	1788	2012-10-05 12:31:09	2010-10-29 13:28:25	1	182	817	11	719	2609	1547	224.00	14	47.11	CHANGED	phlhl..hGhs.Ro.G.....................oohlp.tlh.........................................................................................................................................................................t.tstthhhttt...........thhthhttthh.tthttht.....thhhhh.h.ttthh.............................................h..h.thhhh...thh...............................hh..........csshph...................hh.....lhhh..Rc...Ph.th..hhs....h...htt...................hhtht.....h........................................................................htthhhthtt............................................hp..ph.tt..pthh.ttlht.h.t.....plspt	.........................................................................................................................................lFl..hGhs.RS.G....................TThlp.tlL.............................................................s...t...............................................................................................tts.thhht.t.....................................thhtt..hhthhh......tthtt.ht........th.h..hh.htth.tt.h..................................................................................................................hh...h.thht..................................................................................t.hh....h...KsPtphh.h........................................................lhthaPsA+hlhhh.Rc.....Ph.ss......htS...t.h............htt...............................................................tht....th.....................................................................h.thhhth.........................................................cphhtcP.t.h.pplht.h.......t..........................................................................................................................................................................................	0	256	451	586
+13312	PF13470	PIN_3		PIN domain	Bateman A	agb	Jackhmmer:A3PJ99	Domain	Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.69	0.71	-3.43	201	1089	2012-10-03 20:43:45	2010-10-29 14:04:15	1	5	687	0	443	1286	243	110.50	21	70.24	CHANGED	plV....lDTNVll.....sull.......................................sthllphh.....hpsthpsh...hotpllpEhtpsl.......hc...t....hthttt.....t.h..ht...............................................................thhpsh.hhsh.....t....D...scDp+hlssAls.........u....p...AshlVTtsh+	.................................lllDTNVll..........ssll..t.............................................sphlhphh.....t..psthphhhosphlpEhtpsl.......t+.h.t....h.thpthtt....hhhhhh................................................................................thspsh.....ht.......hp.......D....cDphhlssAls.........u......p......AchlVTtst....................................................	0	161	315	393
+13313	PF13471	Transglut_core3		Transglutaminase-like superfamily	Bateman A	agb	Jackhmemr:A3PJ09	Domain	This family includes uncharacterised proteins that are related to the transglutaminase like domain Pfam:PF01841.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.75	0.71	-4.30	84	283	2012-10-10 12:56:15	2010-10-29 16:51:48	1	7	246	0	123	398	53	113.40	20	54.94	CHANGED	hlhhlshphhhtthshtth...httts.tst.sssstpph......pplspslptsup....hhPhps....tCL.pulusthhLctp.GhssslhhGVppp..........s..htAHAWlp.sssth.....ls.st...tshppasslhs	....................................................................................h.......thhh.hhs.h.h....h.t...ths...tt..t.sptpph......pphspslptsup.............hsshcs....sCL.pulusthhLp.pp.s.h.s.sslhlGltpp.......................shtAHAWlc..sssth....ls..st....tthptas.l..t.......................	0	38	92	106
+13314	PF13472	Lipase_GDSL_2		GDSL-like Lipase/Acylhydrolase family	Bateman A	agb	Jackhmmer:A0LCN0	Domain	This family of presumed lipases and related enzymes are similar to Pfam:PF00657.	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.24	0.71	-4.14	323	11620	2012-10-02 11:02:24	2010-11-01 11:55:58	1	260	4043	70	3589	11502	2666	188.90	16	56.62	CHANGED	lhlGDS..hs...tG......h...s..........s.s.....................t..t........t........sa...s..th..l...tp........................p.........t....t........s...h.p.h.h.shuh..sG...s.s...st.....p...........................h...........h.t.......p.htp............................................th...............ttps..c..ll.hl.t..hG.s.NDhtt...................................................................t.....ht....hpp...htpt.lpp...l...lpp.h...........p.s.ps......p........l.l.l..l....s.h...s..shh..tts...................................................ttthp....ph.s.....p...t.l.......p..........p..h...u...p..p.t......s..sh.hl...c.htss.....ht.....s........t.........t.......th......t..p...h.ht...................................sDs....l...HPss.tGhphh	...........................................................................................................................................................hlGDShs.....t.G.....h...t...............................................................................................tt......t.......sa....s....th..l....tp............................................................t.............t...t..s...h.p...l...h...N...hu....h.......s.G...t...s...st....p.................................................h............h.t.......p.hpt...........................................................................................t.h.....................ttps...c........hl..ll.t....hG.s.NDhht.................................................................................................................................................................................................................s........hs...h.p.p....h.tps.lp....p...l......lpp.l..........................................p..sps..........p...........l.l.l..h......s..h....h....s.ht..tht........................................................................................................................................pphhp......ph..s............p....h...h............p.....................p....h......u......p...p.h.............s.....s....hl......s..hhth.............ht......s.............t..............................t........................t.......hht................................................................................................sDs......l....H.st.tGhth.........................................................................................................................................................................	0	1283	2468	3145
+13315	PF13473	Cupredoxin_1		Cupredoxin-like domain	Bateman A	agb	Jackhmmer:B3CV67	Domain	The cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.17	0.72	-4.14	62	2319	2012-10-02 17:41:00	2010-11-01 15:20:39	1	22	1660	14	491	3072	708	105.60	23	33.67	CHANGED	thhhlhh..hh.hhsp.....sst..........s..ssptp.....hplplp.ss.........tapPsplplsuGp.hp.lp.lcNpsss..........s..tEac..c.....Lp.hc.cslssGpsspltlssLcsGcYpFhss...hp...p..+GpllV	.............................................................hth........................t.....................t..sshpp......lpls.l..p...st................................tapPt..pls.lpsGp.sp.lh.h.p.N..p.ss.p..................................s...p-h..h.c................................ht..hc....c....s......l..s...s.G......t.p......p..s..l.p.h.s.s..ps.Gc.Y....phsCs.......h.....ph....t...+GplhV...............................................................	0	136	300	392
+13316	PF13474	SnoaL_3		SnoaL-like domain	Coggill P	pcc	Jackhmmer:D2BK05	Domain	This family contains a large number of proteins that share the SnoaL fold.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.52	0.71	-4.07	92	1249	2012-10-03 02:27:24	2010-11-01 16:36:19	1	78	757	19	493	3716	1050	118.60	16	47.55	CHANGED	lpphhspa.tpu.hspsDh-thhshhs.....-csshlG..ssssch..hh....stpphpphhcthh....s.p.s...p..shphph..t..p.hpl....p...t.s.s....ssuhhst..hhph......h......p.h.....t.h...Rs.osl..h.c+pss..sW+lsHhHhS..h..shs	........................................................thhpta.hpA.hpp...tD...hcs.h.h.s.has.................sc....s.......s....h.......h....t.......s.s....s.......th.......hp.........Gh.p....t.h....p...p....h.h.p...t..h..h................s..t..h.....p......sh.p....h.p.h...p......p...hpl.............p......h..s..s....shu...h..st.t....t.h..ph.............p..h.....t...spth............tthh....+s....T...h..l.......h.p+..p......s.s......t.......Wc..lsphHhS......t....................................................................	1	171	331	420
+13317	PF13475	DUF4116		Domain of unknown function (DUF4116)	Coggill P	pcc	Jackhmmer:D2BI90	Domain	\N	21.30	21.30	21.30	21.30	21.10	21.20	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.51	0.72	-4.47	608	1708	2010-11-01 16:51:33	2010-11-01 16:51:33	1	50	79	0	1429	1843	1299	48.20	25	44.03	CHANGED	D+-l...lhps.....lc..ps....s.h.............slpa...s...s...pp.....L....+s........D+......-l...lhp...A..lc.......p..ss....p..............s...l....pass...p................p.l.c	...................................................s+-llhpA..lp...ps....u.h.....................slpa....s...s....cp.......l.+s.........................D+......El.....lhp....Alc............p.ss....h....................s...l.....pahs.t..................................................................................	0	1384	1406	1429
+13318	PF13476	AAA_23		AAA domain	Bateman A	agb	Jackhmmer:A0LBT8	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.82	0.71	-3.99	469	5945	2012-10-05 12:31:09	2010-11-01 17:09:13	1	57	3641	10	1564	18355	6884	299.00	13	41.98	CHANGED	plplps..a.tsa...............p.s.....t...p....l....cF................sp......s.............l..s........lIhG.t.......N.........GuGKoTll.-Al....p..h.s.L.....h.u.....ph......tph...ppt.................................pt...t......tht........ptph.p...........ht.t..........................................ptp.t...tsh.....hclp.............................hpt...tpt...................................................................................................lp......ptp..ht..p...p....pt.pth...............p............tt............t..tp....hh..ph...............pp.h.p.....p..h...lpp................ht..tp...tt.....................................................th...p.....h.....h.h...h..hspp.p.........................................t...........................pp......p....................................................................ph.p.t..h.......p.pt...h.......pp..h..p.p..hpp..........h.......hpp.........................................................................h...........................pt..pp....hpp.......................................php...pl....ppplp...ph.......p..clp	............................................lplps..h.tsh...............p.p......h.....p....l.....-F.......................ss....s.....................l.s...............l.lsG.t...........s...............Gu..GKo........oll...-.Al........p........h...s.......L......h...s...ps.........th..ppt.............................................tt.................ttph.......h.........................................................................................t.p.t....tt.......hpht...................................hp......ttt..................................................................................................................................................................................................................................................h......t.....hh............t....t..t.......................................................t.........................h...th...........................tt..t.....p.h.......htp......................hht...t...t...............................................................................h...t............h..h.ptp..........................................................................................................p...............................................................................................................................................................................................................p..t...h.......t..t......h......tt...............................ht...................................................................................................................................................................................................................................................................................tttt.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	583	1015	1360
+13319	PF13477	Glyco_trans_4_2		Glycosyl transferase 4-like	Coggill P	pcc	Jackhmmer:D2BIQ3	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.05	0.71	-4.34	45	1823	2012-10-03 16:42:30	2010-11-01 17:19:16	1	17	1376	0	466	6381	2986	141.00	15	38.32	CHANGED	Klhhlusss...p...h...a...s...h...+...a....spt...Ltpp....Gh-lclho....css....pphth..ttth.phhpl......p.s......hps....hph..l..p.h....h.pl..p+llcchp.PDllHsHhs..psh.ulhutlh....h.htt.h..shl..losaG.s...Dl...hpt..spps.........hh..ch......lh+.h.shp..pustlh.ssu	.....................................................................................................................................h.........h........h........t...h................hpt.......hh.pt......sh.c..lhl.ls..............psth.......t.............p..hh............t..s...h....p..h..htl..............................s.ht.......................ppt..........hp.......l.....p...h.........................h...pl.....h+....l...l...+.....c....h......p.....D.l.la...s...a......s..h......p.s........s....l.....h....u...t....l.u...s.......p...h....s....t......h.......th.l........h...s..h..p....G...h.........sh........hpp...s.ht................hh.ph.............lh+....h.....ht.....sp.hh.....................................................................	0	196	332	414
+13320	PF13478	XdhC_C		XdhC Rossmann domain	Bateman A	agb	Jackhmmer:A0L5F2	Domain	This entry is the rossmann domain found in the Xanthine dehydrogenase accessory protein.	27.00	27.00	27.00	27.40	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.68	0.71	-3.86	296	2511	2012-10-10 17:06:42	2010-11-01 17:23:08	1	15	1622	6	738	2055	1067	138.90	30	40.65	CHANGED	LllhGAGclupsLsplAttl.G.acVsllDsR...................p.....p.....t.....a.......s...........ts.....sp........lh........sh...s........................t..p..th.......ttl.......p..hs..s.ps...h..l..l..h..THsa.p.hDh.tsLpthL.p.p.........s.st.YlGhlGS+p+ttphhppLt..p..Ghs......tpplsc.lpuPlG.Ls.IGucoPpEIAlSIlAEl	.....................................lllhGAGclupslsphushL.s.acltlhDsR...................t.....p.......hF............P............s..st........lt......s.h.s..................................s.th.......tth.......p.lsspo..h..l..l..l.THshp..hDh..sLptsl.cp.........s.st.YlGhlGS+++ptphhccLp.tc...Ghs.........cpclsR.l+uPlG....ls.lGu....coPpEIAlSlhAEl..........................	0	233	476	620
+13321	PF13479	AAA_24		AAA domain	Bateman A	agb	Jackhmmer:A0L701	Domain	This AAA domain is found in a wide variety of presumed phage proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.46	0.70	-4.75	49	566	2012-10-05 12:31:09	2010-11-01 17:32:31	1	4	488	0	83	510	154	223.00	18	78.95	CHANGED	spsh+hllYGtsGhGKTohstsh....scsLhlDh-sG...htsh.....tscslplp..............sap-htc..............................h...htpp...ls..pYcslVlDolophpchhhthhttp...thscp.sts....hpsYGhhs.pthhphls...thhp..hstsllhsAatspcp.....phsthshh..phts....pstsplhshsDhV..s.h.....t..pt..........Rhh.hpsssthhuKs............................................pLss	.................p...hphhlYGpsGsGKT....o....hs..pph.................spsl.....h.....l.D.h..-.tu..t....h.p.sht.........ssss.l.p..lp...............shpphtp.........................................hltth.t.pp......tp..pacslVIDols..ph...p..c.h...h..htthh........tt.cp.sp..........hpsauhhs...pph.hphlp.......plhp....hshpllhs.....u.+psppps.........tss.t..hspht.phps.......phts....tlhs.sDll......sphth......pttst..t....................thh.h.p....p..h...sc.p.................................................htp.hhh................................................................................	0	35	62	70
+13322	PF13480	Acetyltransf_6		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:D2BI49	Domain	This family contains proteins with N-acetyltransferase functions.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.60	0.71	-4.23	211	1584	2012-10-02 22:59:21	2010-11-02 10:42:47	1	24	914	0	667	4625	1145	142.00	14	36.55	CHANGED	pphR...p....pl+ppt...++h.p....c.h....u...th.ph...ph......s...p....ss....p.s.......hp.t.......h....hphh.......h...p....p.....hptp...........sh...hs.p.s...hht.p...ahcplhp...phtt.......ts..t...h.p....lhhlp....h....s....s..c....h...lAsh..hshhpss..phh..h..hhsua..c.p.....h..s...chuPGhlLhhphlcpshp....p....G..hp.t...hDh....st........G.......s....p...........p....YKp	................................................................................................t....tph+pth+ch.t........c..t...u......h..ph....ph............t....p....s.s....p.p................hp...t.......h....hphh.......t....p....t......hptp...............sh.h............hst.p...ahpphhp...th..................ts...p....h..c................l...h.h.lp..............h.......s........s.....c..........h....l.A.s.h.......l.s....h.....h.....p......s............s.........p.......hh.........h.......h..h....s.....u....h......ctp.........h..p.....phus...s..t.lL....hh....ph...l....cts.hp.....p.....G..hp..h.....h-h....sh............s.......t.................................................................................	0	248	474	580
+13323	PF13481	AAA_25		AAA domain	Bateman A	agb	Jackhmmer:A0L707	Domain	This AAA domain is found in a wide variety of presumed DNA repair proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.11	0.71	-4.90	101	6612	2012-10-05 12:31:09	2010-11-02 11:53:00	1	60	4750	17	1429	15488	5931	168.50	30	36.74	CHANGED	ttp..th...phhs.......hs.h.tt....hss.t..ss....hchllp....s.....hls...tus...hshlsGtsssGKohlshsluhslu..........................pGt.hht.......h.s...pt.spVlalssEss...tt.plp...cRlpt.ht..........tp.h.....................st.....sph.hhhp..................t...................t......h...tt..hppltphlpp..ts....ssllllDsl..sp...hh..ss.....sp..ss.s.ss....h....tthlptlppl.tp.ph.s..ss.llllcHssKs...ss	......................................................................h.t.................c...h.o.sh..tE.......hsR.VLG.....G............GlV...sGo......ll.Ll....u.....GsPGhG......KSTL.L.L.p.hs.s.p.lu................................p..............................................t..tp.lL.Y.....l....o.....G..EES........hp...Ql.p...........h.R..A..p...R..ls...............hst........................................................................spl...hl..h..s................................................................................................................................................cs.s...l.c.p..l.t..t..t..l..c.p....tp............Pc.ll.l.ID..SI.....Qs....h.h.....ts.................sh...su...s...ss.....................h......Rcsss....t.Lh...c.h...AK.......pp...s..........hs..lhlVG.HlTK-G.t................................................................................................................................	0	493	948	1211
+13324	PF13482	RNase_H_2		RNase_H superfamily	Coggill P	pcc	Jackhmmer:D2BIZ8	Domain	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.09	0.71	-4.43	108	1043	2012-10-03 01:22:09	2010-11-02 12:04:53	1	24	932	19	331	2850	1595	173.30	19	32.29	CHANGED	lFaDIETs.......Gl..tstt.sh.....l.aLlGlhhh.....ps..sph.t.....hhp..hhhc.p..s.t-phhh......p...........ltph...sh.....lssaNGpsFD.hshlc..phh...........p.hp.hs..............th......t......al.....DL.h....p...hh.....pp..hsh.........pu....uLKslEch.lGh.p+..c..ss..lsGtpulhh...a......p......p......ah...css-......ps.........h..LcpllpYNcpDshsLhpLhshls	..............................................................................................................hhDlEss................s....h.............t.sp............h..hlh.......G.....h..h....h.........st....pph...........................hht....h.h.h..p....s........s.....tcpthh..........................p.h.....................thh.p.pt......s.h..........................h.hs.a..shp........s........a.-.hshl..pphh......................tph.t..hst...............................................sh......t........hl....D..L...h....p.....hl............cc..phh....................pu.huLKs....l........pph....h..Gh.......ph.....c..ps...h.....s....Gt..p..u..h..ph......a.......................p..............p.............ah......p.p.ts.............tp.......................h..h.p....plh.pYNcpD.lhuhhtlhphh.h..................................................................................................	0	128	259	310
+13325	PF13483	Lactamase_B_3		Beta-lactamase superfamily domain	Coggill P	pcc	Jackhmmer:D2BIZ6	Domain	This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-11.10	0.71	-4.53	85	2488	2012-10-02 15:46:01	2010-11-02 12:47:16	1	7	1789	3	832	7626	2715	181.30	21	68.69	CHANGED	plpalGHusaLlc.s.s.....G.hpllsDPa..............p.......t...hGh..h.st........................hpsDlVhhSp.sh.D.Hsss.....ssl.s...............................tspllts......................s.........us..........hp.l..s..sl.tlpsl.sssp................cph...s.Gh...ph..........s.s...Nsha.la..p...s.....GlslsHLGchsp..lstpph..ttlu.clDVlhlPVsG.......s.hshstcpuhclscpLpPplllPhH	.......................................................................................ploahGHushhl..cs..s.............s...pp..lllD.Pa........................................................t..........t.sh...t..t.....................................................spsD.h..ll..l.oH...sHs....D.H.h..ss..................p..h..l..tth............................................................................................................ttps.t.h..l..ss.............................................................................G.........sp............................hp...h.......s.....th...p...l.p....h.s...tuhH...................................................................ss.........p........................................s........s..s....G....h.....l.l.....ph.......t.................sh.p.l...a....H.....s.....G.....D.s...........s.............h.............................t.........h...........t.p...h.......t.....t........lD..l..hh.....l.......Plus.............................sh.sh.s..p.p.A....s..h.h.p..h..l.p..s..p.h.slPhH......................................................................................................................................................................................	0	285	572	722
+13326	PF13484	Fer4_16		4Fe-4S double cluster binding domain	Coggill P	pcc	Jackhmmer:D2BJB3	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.49	0.72	-3.23	562	3179	2012-10-03 08:56:43	2010-11-02 13:29:30	1	73	2633	0	658	3760	1232	65.10	42	16.23	CHANGED	hC.ss.Cst.ChcsCPs.....sA......ls....ts............p..h.c.sp.p....................shsh..................hht..h....c.s..hh...st...hc.sh...h.............hh......huCs...h.....Ct..tlCPaN	.............C.Gs.Cst.Chct.CPT.........sA..........ls....ts............hp...l...D..u.p.+....................ClS.a.........................sh..ph....c..G...hh....s-.p...hR.sh..hu....................scl........YGCD...s.....CQhlCPaN...................................................................	0	209	436	555
+13327	PF13485	Peptidase_MA_2		Peptidase MA superfamily	Coggill P	pcc	Jackhmmer:D2BH64	Domain	\N	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.89	0.71	-4.10	226	1955	2012-10-03 04:41:15	2010-11-02 13:30:43	1	88	1162	0	810	8921	2335	137.20	14	25.04	CHANGED	sssu....ht.....h...stt..thlh..............h..........t...h.....t...s............tt..ts.hp.......tlltHEhsHhhhtp.h...........s..........s.....................s.......thP..hW......hsEGlApahs.......................tp..........................h........p.s........t.......ht.tthtt...tht..ps....ph....hs..................hp...p......l.......pt..sh...................pttpss......h...sY...t..puhhh...spalt.....p....p.h....G...p.p......pl.tp.............h.lp.....ph	.............................................................ht..............................................................................t....t.hh.......tl...lsHEl.sH..h...h..ht..th.......................h.s.......................................t.....pts.....hW........hsEG.hAp..ahs......................................tp....................................h...pt.............ht..tth...tp..........hht.......pt......ph.....s...........................................ht...p..........h............ts..........................ttt.htt........................h....sY.........t...tuh.h.h.......h.thlt.......p.....t..h.....G..........t......hh.thh...h.................................................................................................................................	1	380	616	731
+13328	PF13486	Dehalogenase		Reductive dehalogenase subunit	Coggill P	pcc	Jackhmmer:D2BJ91	Domain	This family is most frequently associated with a Fer4 iron-sulfur cluster towards the C-terminal region.	24.30	24.30	24.70	24.80	23.80	24.20	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.07	0.70	-4.97	89	620	2010-11-02 15:39:17	2010-11-02 15:39:17	1	12	161	0	63	596	74	241.20	24	54.61	CHANGED	ush++PWWVKER-htcPTsElDWslhp+.hD....hppt.th.......................t.t.h.t.h.s..t............t.....htpttp...thtpthppphPGhshps.......................hALt....tuht....s...h.t....sh....t.s.............................shhs........s..sT..P-phG..lP.+WpGT.PEENhpMlRAAh+aaGus.pVGshEl.Dpps+.Klhastst.............................spth.sa.ED..l-..csYp.........sssphlIPs+s+.ahlsasshps....p-hh+ps.............ss...h...t.....ss.u.sh.huYsp..tshlp.sphppFl+uLG.Ypul....s.......s...s.........shsss..suhulhoGlGEhuRhs.hsl.oPcaGshhRh..hthlTDLPL	..................................................................................................................................s.....sWalpph-..p...oh.lDWs.h....t..................................h..................................................thhtp...st.t.t.........................Al.....u.........................h................................h.t............t...tths..hs..hWp.GT.PEEN.thl+sAhphhGus..l.Ghh.l.spp....h...p...phhhtht...............................h.h..h.ps..h......sh...............sstphhhPpphp..hlshsh..s...-hhcps......................sh...ht..ss.sshhs.Y.phs.ht.hhltpFl+sLG.Ypu..h....s.......t...s............shh.s..sshu.hhuGlGEhuR.u..hl.sPca..Gs.hh+h...hthhTDLPL.............	0	25	57	57
+13329	PF13487	HD_5		HD domain	Coggill P	pcc	Jackhmmer:D2BI63	Domain	HD domains are metal dependent phosphohydrolases.	21.80	21.80	21.80	21.80	21.50	21.70	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.90	0.72	-4.00	81	3171	2012-10-01 20:28:14	2010-11-02 15:49:01	1	216	1158	7	1242	5797	561	64.10	32	13.77	CHANGED	ss...Los.p-pt...h....l.p...p+shhshphLpp..l......P..........ht.......pls...cllstppEphDGoGaP.c.uLpu-pIsltuRlL	......................................tLospEhph....h..ppHshhG..hcl.L..pp..h.......................s.............................ht..................tlt.......c.l...s.h.p.H.HE+hDG.o.G.YP.p.G.....Lp....G-pIsl.uRI......................	0	538	906	1111
+13330	PF13488	Gly-zipper_Omp		Glycine zipper	Coggill P	pcc	Jackhmmer:C1ZB73	Domain	\N	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.40	0.72	-4.32	279	2160	2012-10-03 03:18:43	2010-11-02 17:37:02	1	18	1426	0	437	2410	297	47.50	42	26.37	CHANGED	hG.ushGA.ssGAhlG....s...s...s....G......s..t.......s.tG.Ahl.GA.u....lGussGu....s....lG....p..t....h.cppp	.........................GAslGA..hlGAsl..G......s....h....s......u.........s.p.......t.cG.AlI..GA.u....lGA....ssGu....h....lG....h.h....h.-.p.....................	0	116	258	352
+13331	PF13489	Methyltransf_23		Methyltransferase domain	Bateman A	agb	Jackhmmer:A0LD74	Domain	This family appears to be a methyltransferase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.06	0.71	-4.52	129	14355	2012-10-10 17:06:42	2010-11-02 17:48:41	1	362	3944	67	5881	52099	19466	173.70	14	51.54	CHANGED	htp.th......ph...ht.......phl.pp...hh.................ttst...................p.lLDhGsGsG..h..h..................................hp.hh....pp...............p..........G.......h.....p..ht...shD........................................................................................h.....................................................pp....................................paD..hlssh.cllEHlt....s...st................phlppltp...h.l..p..s.s.Gh..lhlps......h.................................................ph..htp..................h.t..h.....h.........ts......sHh....saa.......otpslptlh.cpt.G..ap..lhph	..................................................................................................................................................................hhh...............................h...........................tst..................................p..l..L.D.lG.s......G..s....G....h....h.............................................................................................s.t..hh...........tp..................................................t.............s....................h.........p..lh.....GlD.h...u....thhphst.........................................................................................................................................................................................................................................................................sp..................................................................................................paD....h...l....h....s.....h.....p.....s........l.....p.....a....ls...........-.........t...........................................p..h...l...p...p...h...t...p................h...L.........c...P.......G...G..h.....l..h....h..ss..........sh....................................................................................................h........................................................................................................................................................th..............h.h...................t.............h........h.h.....................t......................................................................................................................................................................	0	1716	3566	4946
+13332	PF13490	zf-HC2		Putative zinc-finger	Coggill P	pcc	Jackhmmer:C1ZG19	Domain	This is a putative zinc-finger found in some anti-sigma factor proteins.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.68	0.72	-3.98	461	2372	2010-11-02 17:57:24	2010-11-02 17:57:24	1	52	1229	16	847	2033	89	34.60	27	15.34	CHANGED	C.p..c.hp..phlstalDsp....Lstt.p..p.tplcpHLtpCssCpp	...........C......h.....thltsal-Gp....Lstt.c..p.tplcpHLtsCspCp......	0	368	627	768
+13333	PF13491	DUF4117		Domain of unknown function (DUF4117)	Coggill P	pcc	Jackhmmer:C1ZFF5	Domain	This family is frequently found on DNA-translocase FtsK proteins at the N-terminus. The function is not known but might well be enzymatic.	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.19	0.71	-4.81	92	2646	2010-11-02 17:57:43	2010-11-02 17:57:43	1	4	2575	0	664	2313	1905	162.10	24	17.91	CHANGED	p+hhcEhhhlhhhhhulalhluLlSa...s...ssDPu..............W............sp......sss..ss.ts.lpNhuGhhGAalADh.hh.h.lhGhuAahhshhh...h...hhs....aphhpp................p..............p..p............ph......hhch......huhhlhll.sss.ul.h....uh.phhth....t.......th.shs.sGGllGphlush....hhphl..GhsGuh......Ll..llslhhluh..slh....sthS.........................W...l...pl...h-............plG	...........................................t......hh.hl.hhhhhshhlhhu.lhoa.........s....tD.su...............a................................sp......ss..........hpNhsG.hhGAaluDhlh.h...hFGh.hAah.lP.lhl...h...hhs...hhhhpp...................................p......s.tp...........th........sh+.h...........l.G.h....l.h...l.l.l....ss.s....u.l.h................s.l......t.....hs............s.....................h...h.u...uGGllG.t.h.l.u.s....h...........ht..s....h....l....sh.h....G..us.......l.l....Lls..l.hhhul......hlh......s..shohhplht...........................................................	0	226	437	557
+13334	PF13492	GAF_3		GAF domain	Bateman A	agb	Jackhmmer:A0LBX7	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.34	0.71	-10.37	0.71	-4.04	153	4956	2012-10-02 14:34:25	2010-11-03 10:47:51	1	693	1936	7	1590	12597	1586	135.70	16	20.13	CHANGED	sh.c..plhpps........hph.lt.phh.s.sct.....ss.lhh...h.c..ps..pt.th......phh...ssh.....t..ptth..tt.....................................................sl.s.......tsp.s.lhp.....tshppt..p..h..h....h.........s........h.......tt.......p......p............h....................h..s.s..........t............sh.........hh...lPlhs...tt.................pshGlls.l.t.....p.t.........s.tp.p.......h..s..t.pph.phlpt..hushluhulpp	......................................................................................................................................................................................................................................pplhpph...hph..lt..phh..s..hcs........ss...l..hh........h...c......pp.........tt..ph............phh....ssh........tt...p.......................................................................................................................ph.s...........hsp.s.lsp.......ts..h...cpp..........p....s.......h......hh.....................ts...................h..........tp...........p........s...........t........................................................h.s.h...................p.....................sh..............lh...lPLhs.......ss.......................phhGllh.l..t.....p..s..........................p..tp..t....................a...s...t..cph.plLpt....hAshlAhAlpp..................................................................	0	627	1138	1442
+13335	PF13493	DUF4118		Domain of unknown function (DUF4118)	Bateman A	agb	Jackhmmer:A0LBX7	Domain	This domain is found in a wide variety of bacterial signalling proteins. It is likely to be a transmembrane domain involved in ligand sensing.	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.47	0.72	-3.84	102	1922	2010-11-03 11:55:06	2010-11-03 11:55:06	1	58	1608	1	460	1522	70	101.40	25	13.48	CHANGED	th..l...cshlhhhlshh..lshhlts.tts.....h.t.sh.hh...h...ha..l..lslll.hu.lta.Ght.ulhuull..u.hsh.....hhhhh.h.t.h.............shhhht.p.........hhhhhhhll....lullsGth.ssthppp	........................s....slhhhhh..ssh....hs.hhh.t...hst......h....s..hh....h...la..L.LuVlllA..l.hh.G.h.h.s.ullAull..ss.ls.a.....shaFh.s.s.h..........................ohsltcsp............YllTFslhLh.lullsusLssth+.................	0	139	291	383
+13336	PF13494	DUF4119		Domain of unknown function, B. Theta Gene description (DUF4119)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0594	Family	Based on Bacteroides thetaiotaomicron gene BT_0594, a putative uncharacterised protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2]	27.00	27.00	80.80	80.60	22.10	20.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.23	0.72	-4.00	3	17	2010-11-05 17:33:43	2010-11-05 17:33:43	1	1	16	0	1	13	0	95.60	61	72.61	CHANGED	pcSKKsuKNNsuspph+olE+..-+Qs+-EIIScDELEKRsGITGDt+tYLTsaLRpFhEG-tHpsYsKKLpsLAcYIaDp+ILYIsKHGGYKLMElS	.............puKKGSKNsKsKRNVQThcKAPs+pSKEEIISEEEL-NRIAIoGDIRLYhTMaL+IFIDGaF+HPKKKKLINLAQYIYDQKVLYIHKHGGYKLMELS.	0	1	1	1
+13337	PF13495	Phage_int_SAM_4	Phage_integr_N2;	Phage integrase, N-terminal SAM-like domain	Bateman A	agb	Jackhmmer:A0LBL0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.63	0.72	-3.66	83	3438	2012-10-02 14:21:04	2010-11-05 17:53:17	1	21	1789	4	599	5743	1666	84.40	20	27.95	CHANGED	llcphppth.+h...cthuhpTpcsYhhhlpp....alpah....p......+..........p..P.pphssp-l..........ctFLstLs..pcp.....susuTppps...lsALhFhacplLppshst	................................t.hhp....h..ph......tthS...pThpsYhptlc.p..........Fhp.ah.......t..........c................................p........p..p...l...s...s...p..-....l........................ctalsaLt........c+p.........................hShsThspt......hsuLphh.ap.hlhpp................................................	0	213	418	518
+13338	PF13496	DUF4120		Domain of unknown function (DUF4120)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2585	Family	Based on Bacteroides thetaiotaomicron gene BT_2585, a putative uncharacterised protein.  As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	27.00	27.00	27.30	38.90	24.70	26.40	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.42	0.72	-3.97	6	44	2010-11-05 21:26:43	2010-11-05 21:26:43	1	1	29	0	6	29	1	93.80	70	87.90	CHANGED	KIhC.QEHY-pVVpYAKSIsDpTLQpClERLKQWEcNsssPCEIELYYDaAPYSFGFspRYPDGpsGIVGGLLYHGpPDcSFAVhl.pPFHGWoIHT	....KIhs.pEHa-pVtcYAESIGDToLQcCLERLKpWEcNPstPsEIpLYYDHAPYSFGFsp+YPDGRpGIVGGLLYHGhPDcSFAVTl.pPFHGWpIHT............	0	1	6	6
+13339	PF13497	DUF4121		Domain of unknown function (DUF4121)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2588	Family	Based on Bacteroides thetaiotaomicron gene BT_2588, a putative uncharacterised protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	27.00	27.00	27.70	27.50	19.20	18.70	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.67	0.70	-5.38	7	50	2010-11-05 21:42:42	2010-11-05 21:42:42	1	1	30	0	9	43	1	254.20	40	94.59	CHANGED	psps+YslEoLpphNs.aD+tatlsQcDVDhsNRhlplIEpsRSchh.PpsGDplhYloRpGDaaspAhI-thss+p..lpIC..P.lPFsacstsslthsspGGsap.lpscslK.suhppttF+sWGHsGtCuNGuVhFpApV.hWpYpEP-PLYGcaT..Tcsap+aalpKp.-sE..st.hYpu.shshhscp-hcphlt.hcGplFpG.hpsplVlWsaRh-ahhLs.pEWpphc..Ap.Rhh.ht.p.VKIlpDh-pHhshFY	................hpshYslEoLphLNhh.DptaslscpDV-KVNphlp+hEcsRschh.PpsGDslhYlo+tGDYaspAaI-phs..s+p..lpIC.hPpsPFsac...stpshthsspGGsashlsscpl+.suhpptpF+pWGHsGtspNGuVhFcAhVthWcYsE.P-PhYscaTT+pWp+aaIc+ps-.E..su.hYpu-shohhsc-ELcphls.hcGplFpG.hssp.hllWsaRh-hhcl.sstEWpthct.sphRhhahthp.VKIhpDccpHlsThY................................	0	2	8	8
+13340	PF13498	DUF4122		Domain of unknown function (DUF4122)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_2607	Family	Based on Bacteroides thetaiotaomicron gene BT_2607, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	27.00	27.00	52.90	41.70	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.46	0.70	-4.97	3	36	2010-11-06 00:25:54	2010-11-06 00:25:54	1	1	27	0	6	28	0	204.50	43	88.78	CHANGED	EEIVYLSIRluCsuYLLYKVaGQK+RIccICDLLYuK.PPVK+ccsEsV.suEPGu-o-VMGSTRFVYLDENAGKTVAPYMSQPLETuuDFIGEEEDVsEEEVECKLPLEEMRMLKEEQEELDucSPEVEAVSPsVTPcDL-NlG-VLh+LN-AspDEsKShRAAhTLHSIRETDLFElFSSQVENKslIEELMGKYLDc-GNPLPLR+c+c.NPVs-sWRQ	...............................................tllYhslRhsChsYlLYpVht.+c+ltpl..CsLLYs....shpp.ctEps...spssss..t...s-VMGpTRaVYLDENAGKTsAPaMSQPLE..p-hIGEDEDIsp-DVECpLsLEcM+hLp-EQEEL...Du.ps...P-sEslo.ulT.cDlpNVGDVLhphstA.pDccKuhpAApTLa.uIR-TslF-lFsSplpNpphlEcLlcchlDc-GNshPL+ppp.p.spssspWR.p.................	0	1	6	6
+13341	PF13499	EF-hand_7	EF_hand_5;	EF-hand domain pair	Bateman A	agb	Jackhmmer:A0LDI7	Domain	\N	28.10	28.10	28.10	28.10	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.30	0.72	-3.83	146	22951	2012-10-02 16:17:27	2010-11-08 14:23:57	1	974	2128	881	12350	22877	1126	70.20	26	23.94	CHANGED	plpp....h...................F.pt..hDtsp..sGhlshp.-ltphhppht.......................................ppphpp.........h....hp..phDts..tcG.plshpEFhp.hh	.................................................................................................................................................................................................t..pp.....s...............F..ph....aD.p.D.s......sG.hI...o......tp...EL.pp.hh.p.s.h.s.............................................................................................................................................ppph...c.p.............................hh.....h..hp........ph..Dt.D......sD..G..pl..s..ap.EFhph...................................................................................................	0	4511	6719	9545
+13342	PF13500	AAA_26		AAA domain	Bateman A	agb	Jackhmmer:A0L3M2	Domain	This domain is found in a number of proteins involved in cofactor biosynthesis such as dethiobiotin synthase and cobyric acid synthase. This domain contains a P-loop motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.16	0.71	-4.71	55	5230	2012-10-05 12:31:09	2010-11-08 15:01:41	1	28	3140	43	1197	6492	1083	206.80	25	57.02	CHANGED	+slhloGT-TslGKTllossLspuh.........p..ss.....YaKP.l.QoGht........p.ss.........Dsphl.pp...lhshsp.s.hh....hs....................................................psht.lptPh.oPph.uAph-.s...hsls....lppl................p.lsp.s..s........chlllEGuGulh.VP.lspp.ph.hDlhppL......shsllLVups...sL.G.o.......I.N+s..L....Lolcsl.+.....s.....+....sl.s..lhGllhNs......tss...........c................shptl.pph.st.........l......slL.uplPhhsplss.pp	.......................................................................................thaloGT..cTsVGKTslotuL.hpu..hpp.......................pG.hp..ss......................s.aKP....l...ssGsp..................................p...ss............D..s..thl....pp.............h.s....s....h.....s....h.....s....hp.....th.....................................................................................................................................................s.P.ht....hs...p...s......h......us........pl....uu...p....t..s......h.s.l.............hppl................................hpp..l.s.p..p..s..........................-hllVEGu....GGh.......h.....s.......s.......h.......s........s........p.....t.........s.......h.........h.......-.hspph...................ph.P..l....l..l.Vsss....pl..G..s..................l...sc..s.....h.....L.o.h...p..s.l..p.....p.....c.........s.l..s..lhGll.hNc........h.tss..............c....................................th.t.hl...t...p...h...hs....................h..........Pll..G..tlPh........p.........................................................................	0	335	731	1019
+13343	PF13501	SoxY		Sulfur oxidation protein SoxY	Bateman A	agb	Jackhmmer:A0LE08	Domain	This domain is found in the sulfur oxidation protein SoxY. It is closely related to the Desulfoferrodoxin family Pfam:PF01880. Dissimilatory oxidation of thiosulfate is carried out by the ubiquitous sulfur-oxidizing (Sox) multi-enzyme system. In this system, SoxY plays a key role, functioning as the sulfur substrate-binding protein that offers its sulfur substrate, which is covalently bound to a conserved C-terminal cysteine, to another oxidizing Sox enzyme [1]. The structure of this domain shows an Ig-like fold [1].	22.00	22.00	22.20	22.00	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.32	0.72	-4.01	101	444	2012-10-01 19:22:21	2010-11-08 17:43:11	1	3	280	16	196	483	305	109.60	32	55.82	CHANGED	shhpshhGspsh......ssplplpu...PphAEsGuhVPl..slpss.h.......lcpltlhs-pNPsPhsusFph.Ps.supst..lusRl+lspsosVpAl.ucst.cGphah.usptVKloh.GGC	............................t..hpthhGstsh...t....sstlplsu...PplAEsGusVPlsl....ss..s.hst.........lcpltlls..-p.....N....PsP....hsA...sFph..Pt....sststluoRl+lup.oosVhAlucst...DGphah.usppVKVoh..GGC....	0	44	122	160
+13344	PF13502	AsmA_2		AsmA-like C-terminal region	Coggill P	pcc	Jackhmmer:B8J2T2	Family	This family is similar to the C-terminal of the AsmA protein of E.  coli.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.25	0.70	-4.99	168	2606	2012-10-03 05:41:17	2010-11-10 11:25:13	1	26	1712	0	739	3716	1170	219.90	17	21.31	CHANGED	luplpsplph...p..s..s.........sl.plsslp.hs..hssupl..ss...sup...a..ps..p.........ss..s..p...........sphshplpstslsphh.......pt.hs.hss.......s..l.p.G..p..hs...hshplsh.p.sss.ht....t.h.soLsG...shphpltpG...........plt......p..........................hp.ph.......................shsshhsp...........sh.sa....cslpushplpsGhhps.cs.hplpus.suplshp.GphsLsp..pp..lshphslssphst.hs.hsh...................hh.hhht..htphs....sl........pa..p..lsGshssPp	......................................................................................................................................................................................................................................tphphphth....p....s.s..........tl..plppht.hs...h.h.t.u.pl....pu........sup....hts..s.............ss..t...p..............................sph.p.hp..l...p.s.hs..ls.t.hh.......................................ph.hs..hss....................................s..l...sG...p....hs...hs.h.s..l...ph..p.sss..ht.....s.....h...ssL..sG..........phphp.l.t.pG......................plp.........ph........................................................h.hp............................................................................thshpsh.hsp.......................sh...hF.....cslp.....u..s.....h...pl..p..s....Gl.hp...s.ss.h....h..l......p.....us...t.u.....p......l.s.....hp..G.pl...s......Lsp............pp......l..sh....ps...sls.sphs.t.......................................t...h..tt..h.........l.................ph..p..lsGshspP......................................................................................	0	242	470	596
+13345	PF13503	DUF4123		Domain of unknown function (DUF4123)	Bateman A	agb	Jackhmmer:B5FDW6	Domain	This presumed domain is functionally uncharacterised. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important.  This domain is sometimes associated with the FHA domain.	22.20	22.20	22.20	22.20	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.57	0.71	-4.15	139	819	2010-11-10 11:40:33	2010-11-10 11:40:33	1	3	345	0	199	758	13	123.60	20	45.28	CHANGED	phYhllDusph.s.p.....hhpthh..pt..t.t....t..hts..Latss.shppht.phuPa..Ll......pl..................s............s......h........tphhpp....t...tpsh..........u....h.hlt.......S.s..t.........shp..plhp...HL+p..hl.pl.ph.s.p.G.c.th..hhRaaDsc....lh....tsh......lssh..............tptst.......hh	...........................................................hahllDshhh....p.....h.tth.....th....t...t..hhs.Lattp..sh..ttlt...phuPaLlpl.................ts................s....hl........pphhtp............tt.tt.h.............u....h.hlt.......S.s..t...................................sh.s..pLt.p...HLpphlt..s.ph.s....p..G.c.ps..lhRaaDsclh.sh..hps.hs...tpht.h...............................	0	40	78	125
+13346	PF13504	LRR_7		Leucine rich repeat	Bateman A	agb	Jackhmmer:B5ETY5	Repeat	\N	22.00	7.00	22.00	8.30	21.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	17	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.76	-6.69	0.76	-7.30	0.76	-2.74	1228	2943	2012-10-02 21:32:02	2010-11-10 13:37:07	1	941	590	28	1121	55766	2241	18.00	36	3.46	CHANGED	spL....ppL...p...l..............pp.....s.....p.....l....p......p.....l...s	........................sL...cpL...s...l.......us...N......p.......L..s.....p...LP...............................	0	385	667	922
+13347	PF13505	OMP_b-brl		Outer membrane protein beta-barrel domain	Bateman A	agb	Jackhmmer:B5ESE4	Domain	This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	27.70	27.70	27.70	27.70	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.63	0.71	-4.33	190	7576	2012-10-03 17:14:37	2010-11-10 14:45:20	1	53	2032	12	1809	11637	730	195.60	15	81.14	CHANGED	hshshhss.hu...ss..shu................ssp..........tsh.h...........l..s..s.u...h..shs......sh...s...................sss.......ss.s.t.......................s...s..sh..sltss.a...p...h....s....s......h......hu..l.ps.sh..s.............h......tss.....pttss.......................s.hp....hphht....................hsss......ht.h.p.....h.sh.....ss.............h..p....hYs......tsGhs.............................................hsp.p..hp...hts.................................ptstsp..huhsh..us..G......lpaph......s.....p.....ph....t.l.....ss..cY.p..h..t.ph.........................ss..............hcs.......ss...hpluluY+F	.........................................................................................................................................................h...hhhhh..hs....ss...shu....................................sts...........................th...h.........................l...s.......s.s....h...uhs............ph...p.............................................st..........t..p.s............................................s....hsh..sl...ths....Y.................p.....h..........s.......s.........h.........hu....l....ps..s.h..s.....................................h........tpt........pptss....................................................p..p.....ph.tt...............................................................ht..hp.............st.h.s........h...sh.......sph............hp......h.Ys.......tsGhu......................................................................................................hs.p.h.p..hp......t..............................................................spsps.p...hu.h....s.h........G.s......G.............lp.a.p.h......................s..............p..........sh......s..l............p.h...p..Y...p....h.....h.ph.........................................................ts.................hp.......ts.........h..hh..G..hsapF...........................................................................................................	0	544	1089	1459
+13348	PF13506	Glyco_transf_21		Glycosyl transferase family 21	Coggill P	pcc	Jackhmmer:B8IZF6	Domain	This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.	21.30	21.30	21.30	21.30	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.97	0.71	-4.98	54	703	2012-10-03 05:28:31	2010-11-10 14:55:10	1	8	542	0	308	9471	1198	168.40	23	39.16	CHANGED	P...p..l..c....lhhs...ss....shuh.N..P...KlsNhhhshpt....Aca-hlllsDuslhlsschLpplssshpp...psGL.Vou.hsh.ssssp...u....hhutl.t.ssh...h.......s.sh.....thhhu....h...t.....uh..shshGtohhhR+psL-phGGhpulsphLAEDhthu.phlpst.Gh+ltlssts.ht.p.s.ss...tp.htt...hhsR.h..RWu+	..........................................................................................................................lhls..st....hus...N.s......Kls.N.Lh....hhct...........sc.....a......-......h.ll.l.s.Du.D.h.h.l......p...s...c....h...L.p...c..........l.s.......s..s..h.............s................-.............p...........l.....G.....l......V.........o.........s......h.....s..........h........s....t.....s.s..p........s..................h.h.u...t..l...t...tha..h........................s...h........sshhhs.............h...t.........................tt...t.h...s..h...G....t....s......h..........s......h..R......cs......s......L......c..............p......h..............G......G...........h......t.........s......h........t...........p...........t........L..........A.........-...D.a.hh...u.......phl......p.......s........t......G.......h.......+......h..h..h..u..s....s..hh..p.sss............phtp......hhp+....h...pWs........................................................................................................	0	96	178	246
+13349	PF13507	GATase_5		CobB/CobQ-like glutamine amidotransferase domain	Coggill P	pcc	Jackhmmer:B8IZF6	Domain	This family captures members that are not found in Pfam:PF00310, Pfam:PF07685 and Pfam:PF13230.	20.80	20.80	20.80	21.10	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.69	0.70	-5.48	255	4672	2012-10-03 00:28:14	2010-11-10 14:55:38	1	18	4440	7	1177	3706	2727	235.40	37	29.43	CHANGED	+P+VsIlpt.GsNschEhAtAFcpAGhcsh-.V..p.........h.s...-.........l.........h.........su.........ch.........s.Lcc..hphlshsGGFShGDsh.GuGcu..hApslhht.......plc-phppFh.s.R..DshsLGlCN.GhQhLspLu...Ll............Ps...............s...........cp.PphspNpSt+aEuRhspl..h....h.ss.p...S...Psl..hh.psh...s..shplP..V..uHGE..GRhhh.....spphhp..plhssstlAhpYVDs.......p..GpsTtp......YPhNPNGSstuIsGlsSsDGRlhuhMPHPERshcshpps.hs............t.t........t............ushhclFcNAhpah	...................................................+lAllt..GsNs-h-h..At.Ah....c.c.u.......G.......h.-.s...ht..Vh..........h...s.........l.........h.....ts.........ch...................s.L.ps..h...csllhsGGFSYGDhL...tuGt.h..hu.tphh........stltptlppah.p.c..ssh.sLGlCN.GhQhLs.chu...Ll................PG..................................shh+Npu........t+........F...u..+..hshl..h..............l........s...p......o........s...lhh....psh...p...thplP...VuHGE..G+ahs............ss.p...p.l....t..pLc.spsp....lsh+Ys-t....................s...t.......................hNPNGSspsIsGlss.psGp.VhuhMPHPERshcsl..s................................................hh.................................................	0	380	751	997
+13350	PF13508	Acetyltransf_7		Acetyltransferase (GNAT) domain	Bateman A	agb	Jackhmmer:B5FCA0	Domain	This domain catalyses N-acetyltransferase reactions.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.38	0.72	-3.82	163	13825	2012-10-02 22:59:21	2010-11-10 15:58:29	1	107	3917	33	2973	41376	6818	86.50	18	43.91	CHANGED	ppp..p.hhsh.pp...........ssc...ll.u...hh.tl.................tt....t........p...ht..........hlt.......tl..slpsphRspGhu...pp...llpt......h.......h...pph.....t...............t.....p...t...h.........h...........l............h............s.....p.......s.......p............t..........h.paYpphGFph	..................................................................................................t....hh.h.h...p..........................ps.p.....l.l...u....hh..pl.........................................................h......t..................p.....hh........................................hlt........tl.....s...V...p.s.php........u..p..G..l..G......pp....Ll.pp..........h..............t...pp.h...........t...............................................................t...........p....s.......l............h...................l...............t................................s........p........p.........p.............................s.............h..sF.Y..p.+.h.GFp............................................................	0	930	1796	2449
+13351	PF13509	S1_2		S1 domain	Bateman A	agb	Jackhmmer:B5FDY3	Domain	The S1 domain was originally identified as a repeat motif in the ribosomal S1 protein. It was later identified in a wide range of proteins. The S1 domain has an OB-fold structure. The S1 domain is involved in nucleic acid binding.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.56	0.72	-4.05	96	2158	2012-10-03 20:18:03	2010-11-10 16:15:05	1	7	1694	1	363	1496	70	60.30	29	26.77	CHANGED	lGphssLplh+ps.chGha.L.......s...ssp....s-lLLPpp..tl..s..cs..hplGDplcVFlYhDu-c..+llATsp	....................lGphthLpVlc..........p.......s.c.......h.Gha.L.................p....tst.......pslhLspp........Eh................pp....hplG-plpsFl.Y.h.Dpps.+lh.ATp..............	0	127	239	313
+13352	PF13510	Fer2_4		2Fe-2S iron-sulfur cluster binding domain	Coggill P	pcc	Jackhmmer:B8J1F8	Domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.66	0.72	-4.17	254	5655	2012-10-02 17:47:23	2010-11-10 16:31:22	1	204	3363	9	1816	5235	3983	79.40	31	11.18	CHANGED	sp.lshphDGpp.hpuhtG-TlAuALlusG................l.p.ls.+.oh.t......htpP...Ruhhsshups.ssLVpl....s.........u....ps...s.h.pAshs.lt-GhplpoQss	...........................................lplplDGp..p..l..p..s.....t.......G....s...ol..lpAs.tp.sG..........................l..p..lP..p..hCa....................p..............stl..s.s......s.G.sCRhCl.V..-.l.....c.........................s....t....t...l...t...uCsssl..p..-..GMhlpopp......................................................	0	630	1190	1513
+13353	PF13511	DUF4124		Domain of unknown function (DUF4124)	Bateman A	agb	Jackhmmer:B5FFC8	Domain	This presumed domain is found in a variety of bacterial proteins. It is found associated at the N-terminus associated with other domains such as the SLT domain and glutaredoxin domains in some proteins. The function of this domain is unknown, but it may have an Ig-like fold.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.29	0.72	-3.92	232	1444	2010-11-10 16:35:35	2010-11-10 16:35:35	1	18	588	0	495	1312	147	82.30	18	43.19	CHANGED	hhhhhh......ss...ss..s...u..u....plY+WsDps.GpspaoDp....Ps.t....s.s.ps.p..pl..........................phts.sss......................hs.t.....s.....ss.tts.......tpt	.......................h.hhhhh.....ss.....ss....s....u...u.........slYcasDss.Gsspao-p...........Pst.....s.s..pt..p..pl.............................................p...........................................................sttttttttttt.............................................................................................................................	0	129	310	423
+13354	PF13512	TPR_18		Tetratricopeptide repeat	Coggill P	pcc	Jackhmmer:B8IZE5	Repeat	\N	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.92	0.71	-4.16	19	80	2012-10-11 20:01:04	2010-11-10 16:50:44	1	7	80	0	30	1458	1509	130.10	30	50.38	CHANGED	sc-slP-hssuplYspAQcsLpsGsYpsAIcpLEuLDsRYPFGsYupQsQLDLIYAYYKss-hshuhAoIDRFlRLNPsHPNlDYVhYMRGLsshshDcs.h.phh.....phs.t.st..................tAFc...DFppLlp+YPsSpYAsDAppRh	..............................................p.s.splYspupp.tLpc.t.p.ac...pA...hpph.c.t..L.cs+..aP.h.u...au...p...Qsp..L...pL...h.Y..........u....a........a..cs...sc...h.......tAhu......sh-RFl.....+L.pPs.H........s.s.....l.....s.....Y.sh....Y.h....+GLsp..h...t.......s................................tsc+...D..p.sh............................................Aht..phppllppaPsotYu.cup........................................................................................	0	12	19	26
+13355	PF13513	HEAT_EZ		HEAT-like repeat	Coggill P	pcc	Jackhmmer:B8J2H7	Repeat	The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see Pfam:PF00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.	20.00	18.30	20.00	18.30	19.90	18.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.20	0.72	-3.35	261	1731	2012-10-11 20:01:04	2010-11-10 16:59:27	1	168	403	18	1145	5921	533	54.80	25	5.68	CHANGED	.plR......ptAhh.uL...s..........htt.t.ph...ht...hhtpllshLh.....hh..t....sss...tl..Rptu..shuLupl	.......................................................hR....cuAlh.ul......Gs...............lstsshpt.......hps......hls.pllshLl...........phL.pD.......sps.....tV..Rpsu...shsLup......................................	0	376	651	956
+13356	PF13514	AAA_27		AAA domain	Coggill P	pcc	Jackhmmer:B8J072	Domain	This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.	29.20	29.20	29.30	29.30	29.00	29.10	hmmbuild  -o /dev/null HMM SEED	1111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.09	0.70	-13.83	0.70	-6.88	10	1921	2012-10-05 12:31:09	2010-11-12 16:18:39	1	17	1239	0	319	1500	94	415.80	15	69.93	CHANGED	laGsNEAGKSTlRsAlpsLLFGFPtRoshs.FlHs+psL+lGGsLs....tcsGupLcFpRl++sst...oLhsscGc.sls--sLsshLsGhs+phF-ulFulDccsLhpGG+pIl-ApsclGphLFuAuAGlGS..LssVc-pL-cEt-pLaKPp.GppstINsulpphK-lppcl+chpl+scsWccppcsLccuccclppl+ccpcpL-pc+pclERlppltPhlp-c+uhpppLutl.uEslphPscus-Rhtphcschpsspppl-phpc+lpplcschsuIplDc-hLucAssl-uLpppcsphcpupp-lpphpuclsstcc-tsuLttQlG.Pshspsslcuhcsuhss+cplspLsp.......c+psLcptlcsApcpLcEpccclcplcpphsulssh..spsLhtul.ss.thhshtt...thtstcpcltps++cttpulspLG..attsl.t.hthslP.htplpthp+ctpEhtsstppt+cchpcsptpLtpl....tlptpthstssslsoss-ltssRstR-tlWps.................hs..tshs.th.chlppADpLsDphhspsppsupltplRpptEptptRhtthptchtshcpphAthctsWttthtshu.hPh.s.tth.sWltphpthh.t.pth.ptptEhp.hhptttchpttLtt.Lth.u.........t-LsthLptucphlcphc+sutccspL-c+hppscpuhpcAcc+ppcApcpl-sWcccWpphlhphtLsuphosstsls.ul-hhpchppchpcs-chsp.Rlpuhcc-lucFcpclcsLscshssth.s..s...pth+tLpsRLppA+-cupthc+LsEclcphccclspsspslpptptclssLhc....hApssohE-hhssscRu-ptcchccplscLppplsphssulsltuLttchsth-ssplpucl-plspcl-c.hpsphscLsppluctcsplupl-GsosAApltcchppthuplp-tAEcalpluhApplLppsh-RYR-s+psPlLp+AuEhFspLThGcFopLpsDs.-cpP.hLsucRssGpplpltpLSpGTRDQLYLALRlAsLEhhhtpppshPFllDDlFlsFDDsRocAslcsLc-Luc+sQVIaFTHHcHLlshstps.asspspllcL	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h........................................t....................h........hStush-.lhh.hRhu.h.ht..............................h.P....h.lh.DD.hh..D..Rht.hhthh...p........s.....t.....t..............Q.llhho....t..........................th......................................................................................................	0	119	219	276
+13357	PF13515	FUSC_2		Fusaric acid resistance protein-like	Coggill P	pcc	Jackhmmer:B8IZ01	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.84	0.71	-4.22	286	4566	2012-10-02 19:04:43	2010-11-12 16:27:32	1	34	2561	0	1051	5938	148	130.10	23	22.04	CHANGED	l..uh...hl..s.....t.h......h...s.h..........t.......+sh..........Ws.sls....shhlh.........p..s..s..hssshp+shpRhlGTllGs.hluhh..lh....h........hhs...s..s....h..h....hh......h..l....lhhh.....hhhh........h...h..........................h....s..ts......Y.....sh.ts..hh..l..T........hhsl....h.hhsh...............sssht.................hsh....RlhssllGsh....lulls	..........................................hhh..h..hl.s.p.h......hsh............t............+ua..........Wh.h.lo..s..hhl.h......................p..s...shssotpRhhpRllGTllGllluhs..ll........h.................................h.hs.......s..p..........hh....hl.............h.l.....hhhs........shh.h..........h...h...................................h....p....ts......Y.......uh..us.hh..lT.....hhsl........h....h.h.s.h......................ttshp.............................................hhhsRl.l-sllGshlAhh.s.................................................	0	275	612	877
+13358	PF13516	LRR_6		Leucine Rich repeat	Bateman A	agb	Jackhmmer:A5IFW6	Repeat	\N	23.00	8.70	23.00	8.70	22.90	8.60	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.75	-7.04	0.75	-7.40	0.75	-3.27	889	30484	2012-10-02 21:32:02	2010-11-12 16:29:19	1	2898	807	67	21001	56590	2857	24.90	27	9.82	CHANGED	h.....ps..Lp.....pL.....s.....L....s........p..s.p.....l...ss...pu....h.......p....sl....u.............p	......................................pp..Lp........pL.........s...........L............u...............................p...N.p.........l.....sc......pG....s.......p..tls..............................................................	0	10309	14782	17695
+13359	PF13517	VCBS		Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Coggill P	pcc	Jackhmmer:B8J4T8	Repeat	This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.62	0.72	-3.61	1255	7532	2012-10-05 17:30:43	2010-11-12 16:50:10	1	572	812	12	4031	8611	7152	66.10	25	19.29	CHANGED	Dhss..DGthDll..s....s................s....s.....ss...................spl........h..h...t.p....s......s..G....s........hp............h...s.p......h........h..hss..s.................sts.h....s..........s....s....hu..DlssDGp.hDlls	.................................................DhssDG.h.Dlh..s..s............................s...s.....ss..................................stl.........a.h...s..p......u................s..G.......s..................as...............................t.h.....s.t........h.........thss.s...............................................stsh....u................s.....s.....hu...Dhss..DGp.hDlh.............................................	0	2314	3279	3827
+13360	PF13518	HTH_28		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:A5IDV5	Domain	This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.46	0.72	-3.92	193	5836	2012-10-04 14:01:12	2010-11-15 09:27:30	1	87	2346	0	976	15814	2048	50.90	20	29.02	CHANGED	p+hpl...l.ph.hh..p....s..p...shpp.....supphsl...sp.psl.tpWhppap.p.tG.h..s..uLt.s......c..p...p....psp	......................................+hpl....l.ph.hh..p.......u..p.....ohpp................hupcasl...sp.ssl.tpWl+tac.p..tG.....p..uL............................................................	0	285	617	813
+13361	PF13519	VWA_2		von Willebrand factor type A domain	Bateman A	agb	Jackhmmer:A5II27	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.30	0.71	-4.15	168	10039	2012-10-10 16:07:06	2010-11-15 09:44:16	1	392	2980	5	4071	16696	2611	193.40	16	32.32	CHANGED	slllllDhSsSM...........t..sp.....sh..........................................t.......s................Rlst.s.+tth.........tsl...lp..........p...h.........s.ss.....ph......u.l..lsau.........u.......s..............u.................h......h....h............h..................s........h....o...........s....-....t..ssl.....tsh.....l..ss......lssp.h..................................hs..s......s....u..........os....hs...t.ul.....................................tt..Ah....p.hh....................................p..p...t..s.............................tp...s.s.l.lllo..D.......G.....................ts.s..............sp..hh......p...............hh.p...........................................t..h...p..pp..s...hp.....l..hsl.........sl.G..........ss.......ps..s...............................................................t..s.................t..lpp.l..Ap..ts.....u......Gt.......hhph..psss..psls.............ph...hpp.h	...................................................................................................................................................................................................................................................lhlllDs.S.u.SM...................t.sp.................................................................................................................................................................................................................p..........+l..p....t....s....+p.sh...........................pp..h.....lp..........................................................p.......h................s..ss..........pl...........u...l......l..s....Fs................................................................s.......p....................u...............................................................p.........h........h..........h......................................................................................s.........h.........o....................s......s....t....pt.h...........tpt............l...ss.......lp.s...................................................................................s......s....s...................Ts..l.s....t....u..l.......................................................................................................................................pt....A.h.........p..h..l........................................................................................................................................p.....p...p...t................................................................t..tp.......p...h....l....l....ll....T....D........G.............................................................ps.s...........................st..h......p...........................hhp.................................................................................................................................................................t...h.......p.......pp...s.........lp...........l..hs.l..............sh..u.........s.s.....ts........................................................................................................................................................................................t............h.hpp..l....up.......s.......s..............Gt.........................h..h..h............................................................................................................................................................................................................................................................................................................	0	1621	2750	3486
+13362	PF13520	AA_permease_2		Amino acid permease	Bateman A	agb	Jackhmmer:A5ICF5	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.78	0.70	-12.77	0.70	-5.94	61	23261	2012-10-03 01:44:59	2010-11-15 11:34:15	1	79	4110	20	6607	26829	2040	418.20	16	86.76	CHANGED	luhhsshhlsh.....us.h.....hu...ss......h..h.s...s...........hss....sGh.s..hhlhhh.lsshhh...hshthsh.hEl..u..s....hspsGGhhsas......pts....h...........s....phhu.....hhsshhh..hhshhh..sh.ss...h.s....sh.hhph.h..hth...h....t.................ph.t.t................................................................ph..hh.hhlu....lsllhhhhhlshhuh+hu.splp..h.hshhplh.hslhhhllhulhhh....tt....s..hhs.........................tp....s.................hhss.....shs......t.....h..........h...s...........u.h....hh......s..hauhsGa-ss...................sshspE...hp......p..+..s.h.huh......hhuhhhshllhhl..............hsls..hhh.lls..sp.l........s.t..ss..........................h.shhhpth.s...s.p..hhthlls.lhlsl......shhu....slhshhhuss+hltphuc-..........shlP.......chhsph.............s.c..hss........Phtulhhthlls.lhhhl.hh.........................................hh......tsshs................hlhslsshshh...lhhhlh.hhuhl...hh+...hp...p.....ph.......t+.................hh.h............h....h.lshhs.....hlhh..lhh....l.......hhsh...........hs........t.s.........s......stts...h.hhh.........hl.hhs.hh	.............................................................................shhshhhlsh....us.h........h.G....sG.......h...h..h.hs.................................h..hts......sGs...s.....s.lh..h......h....l.....l.s..sl.hh...........h...h...h..u.hs...a.....ucl...u.............s...t.......hP.....p..s......G...G..h..a.s..a.s...................pts..................h.......................................G.....p..h.hu.....................ah..s...u..a.h.h........hl.s.h...hh....s.s...s..s............h...s............hh....hs..s.h..h.......st.h.....h......s.........................th....t................................................................................sh....hh....hlh...s........................h.s.l...l..h...l.h......s.....h.l...s...h...h....G....s...c...h...s....up...l......s...sl....h....s.......h...........ht........l.......h.....s..l..h...h.h.l..l..h...u...h...h.h.h.............ph........s....hhs........................................................................................................ht..s....................................hhst..........shs..........s.......h.............................h.....s............................................u..h....sh.........s....ha...u.....a.h........G...h....-....s..h.................................................s...s...h..u...p-..........sc................p......+....s...hPp...u.l........................................l.h..u.h..h.l..s..s..l..l.....Y..h..l..............................................s..s...hs......h..h..s....h....l...s......pp..l...................s.t..s.ss..................................................................h..s.h.hh.p.h.h...t.................h..s.....hh.s....h..lls....h.s.s.h.l...............................uh.hu.........................sh.hs...h...h...h..s.............s...s..+...l.h.h.u..h..u.c..-........................................................u.h.hP...............ph.h...u...+..l...........................................................s...c...pt.s..............................P.h...t.......u....l...l..h....t.......s.l.l...s..h.lhh...h.h..h...........................................................h............tth.s..........................................hl..h....s.....h....s..s....h....s..hh............l...s.a..h..h.....s.....h.h....u...h..l..........h..l.p.......hp........t.........ph.........tp................................h.h...............................................................h....h...h.s...h..hs.................hlhs.....h..h..h....h....................h.h..h.......................................................................................hhhhhhhh...............................................................................................................................................	0	1861	3597	5318
+13363	PF13521	AAA_28		AAA domain	Bateman A	agb	Jackhmmer:A5IAR3	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-11.10	0.71	-4.28	115	1816	2012-10-05 12:31:09	2010-11-15 12:03:12	1	15	1500	1	435	2151	632	163.30	27	52.65	CHANGED	+lllsGu.usGKTT....Ll....ptL......u........p.p.........G.hs...hs..sEhuRpllppph.....spst.....thh......h..................-hhths.pthh.ptph.cp.h....p..s.s..........p.s...sphlFhDpuhh-shs.Y..h.chh.tt............................s....hss..p.....lt.p........tsp....ptc.Y...ch.lhlhs.s.hs.......l.....pDst.R..p.p.sh.cc.ttph.tpthtp....thpp....huh.phltl...p.ush.ccR	......................................lsIhGGtSoGKo.T....Ll....sp.L...................A..........p.h...................hs.ss..........ss...........E....h.....u........R.....c..hl.pph........stsp...............t.Lp........hp..................................................Dhht..hu.p........ttph..hs.h.......t.st.................h.u...spl.sFhDs...shl.s....s.p...u...a...s...cth..ts.............................................................c.....t.s..h..........lp.s..........hhp......ch+..a........Dl..Vlllp..s.ss............sa.........ssD.uh.R........s...t...s.......t....-.....cpph..pp....hlhc....hlpc........sh....phlpl...psshppR.............................................................................................................................	0	157	265	373
+13364	PF13522	GATase_6		Glutamine amidotransferase domain	Bateman A	agb	Jackhmmer:A5IAK2	Domain	This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes, such as asparagine synthetase and glutamine--fructose-6-phosphate transaminase.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.94	0.71	-4.20	67	6720	2012-10-03 21:14:07	2010-11-15 13:25:09	1	18	4568	0	1845	12173	7462	149.00	32	26.58	CHANGED	PDspGh..ah..ss......p.....................ssLuHs.RLull-hs.ttus.QPh...stssp....h...hlsaNG-lYNat....cl+ppLtt.tGhs..hps.poDoEVllt.hh....pphG........pcsl.p..........clsG.hFAhulaDp.pppplhls.RDch......G...hKPLaatht.........ssshhFASE	................................................................thttttth...............pG.....s.........................sGIG.HT...RWA....TH..GtP....s..p..t..N.A..HPH.............sssp.......................l.......slVH.NG.lIENat....................pL+....c....c....L.....t....s....p...Ghp..............F.pS...pTDTE....Vls+..Llt............................pphut................puhppsl..p........................................plcG.....ua.A.......h.....s.....l.....hs..t....p........s.......s..pllsA......p...........s.......sP..LllGhs.........pt...h..........................................................................................................	0	629	1210	1572
+13365	PF13523	Acetyltransf_8		Acetyltransferase (GNAT) domain	Bateman A	agb	Jackhmmer:A5IFT1	Domain	This domain catalyses N-acetyltransferase reactions.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.70	0.71	-4.33	54	3083	2012-10-02 22:59:21	2010-11-15 13:26:02	1	23	2166	17	599	11897	940	153.50	19	66.16	CHANGED	lRshc...ppD.hs.hlppWhsps+ls..ha.h.pp.st.sh.pth.cp.hhp.tlt...tssathshlu..........thsu...cPhu.........Yh.....Eh.....Y.spcc........h.....................ts.........p..s....tDpGhH..lLlu.ssc.h..hGtshspshhpulh...calF.t..-..tspRllsEPcscNpphhphhpphG.F.phhtph.c.h...P..cKcAt.Lh	...........................................................................................................................................pD.h...hh.....h.....p..h....h....p...p.....s...c..hh........h.....h.....t..t.....t.............t..................................t.t......h.....p......pl.............tp..p.p..h...t.....s.....h...l.s..............................h.h..c..s..........p..s..h.u.........................ah............ph...........h..h.s.p.ps.............h.....................................................ps..................p.s.....t.s...h...s...h..c.........h.h..h.....s...ssp..h.................t..G..c.Gl.u.pth.l......p...s.....lh..............ch.hh...p.....c.........t.........sp..c.lh.h-s..c..s...s....N....t.t....hh+....h.h.c..+.tG....F....ph..hup..h......h...s..t......h......................................	0	136	318	477
+13366	PF13524	Glyco_trans_1_2		Glycosyl transferases group 1	Coggill P	pcc	Jackhmmer:B8J2T1	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.83	0.72	-3.71	238	1210	2012-10-03 16:42:30	2010-11-15 13:26:32	1	65	678	0	497	17241	5704	98.20	19	21.71	CHANGED	l.sLN............hspp..............................ss.ss.....h.....RhFEshAsGs.hllos.............pslcp..h..FpsGp..................-..llhhp...shp-hhctl.cthh..p.ss.p.t.tp.pl.uptutpcl.hs.cH....Thpp...R..spplhs	........................................................................................................ts...s.....h.......Rh.FEsh.A.sGs..h..llo.s.t...........tsh..pp.....h...a..p...s...s.p..........................................c....ll..h.hp............shp....-.......l....h....c....tl....p....h....h..h.....p...s....s....p....p....t.....p..pl....u.....p.pu.h...p.p...l...hp...c.H..........o...a...p...p....R..hpph..t....................................................	0	190	360	424
+13367	PF13525	YfiO		Outer membrane lipoprotein	Coggill P	pcc	Jackhmmer:B8J028	Domain	This outer membrane lipoprotein carries a TPR-like region towards its N-terminal. YfiO in E.coli is one of three outer membrane lipoproteins that form a multicomponent YaeT complex in the outer membrane of Gram-negative bacteria that is involved in the targeting and folding of beta-barrel outer membrane proteins. YfiO is the only essential lipoprotein component of the complex. It is required for the proper assembly and/or targeting of outer membrane proteins to the outer membrane. Through its interactions with NlpB it maintains the functional integrity of the YaeT complex.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.31	0.71	-4.85	30	2784	2012-10-11 20:01:04	2010-11-15 13:53:42	1	103	2215	4	696	2342	2289	181.20	26	61.86	CHANGED	s-hsspplYppAppuLppGsYtsAlcpLEsL-sR..YPFGsYupQuQL-LIYAaYKssDhstAhAsh-RFlRLpPpHPslDYshYMRGL.......oshpt..........tcsh..........c...RDs......sth.....+pAFp-FppLlp+aPsSpYAsDAppRhhaL+spLAcaELplAcaYh+RpAalAAlNRuphllcsYPsT.ustc.ALslhhpuYcpLuhsp.ttcpp.phL	.........................................................sspplY.spA...pp.t.l.p..s.G.s.a...ppAh.pthc.sl..p....sc.....a.Ph.u.s.aup.p.....u........p.l.......L......sa...A...a........Y..c...p........s...-.......hstA......hssh-+....F...l...c.ha..Ps..p........s...p......h.c..Ys...hY..hpGl............spht........................................spsh................................p..RD.....pts.....ptAhpshppll....ppYP...s..S..pY.s.s-App+.hh.hl.ps.....tLuth-...h..t..hu.ca.Yh.............p.p.............t...........t.....a.....h...........A.shtRhp...hhpp..a.ts.....h....c.ul.hh..sa..ht..t..........hh...................................................	0	207	426	568
+13368	PF13526	DUF4125		Protein of unknown function (DUF4125)	Coggill P	pcc	Jackhmmer:B8J0H5	Family	\N	25.00	25.00	60.40	59.80	21.40	20.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.18	0.71	-4.77	22	120	2010-11-15 16:02:55	2010-11-15 16:02:55	1	8	113	0	25	111	3	186.40	37	80.57	CHANGED	cppllcpIlchEWphFppspstuG+AsCQss.p.......sFclMRtSQahsWspphLpSYLpDLppActtGRNLlsEKYARMMphss.P....c..............s...........hpsh..ls...........cIsp...........h...........pht...........Wp+-htc+YPplspt..ts.hps...pD.......s...p.....sS....FETYLRuELtTYS.+TlpLYhphl..pchtppppNLscpshcphVphhGYcoL-cAEc	...............................t.cpllcpIlctEWs.FppspN.GGRAsCQssh........s.FplMRtSQahsaspplLpSYhpDLppActtGRNLlsEKYupMMp.os.P....c.a...........sts.hpshIp...........cIsp...........hplt...........Wtc-htc.......+...YPplupthRsltosEDs..tp...TShETYLRGELtTYSpcTlpLYtphl..tch..t..pp..phNLstphhtphsph.Gapsl--sEt......................	0	14	19	22
+13369	PF13527	Acetyltransf_9		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:B8J1N3	Domain	This domain catalyses N-acetyltransferase reactions.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.26	0.71	-4.28	105	3978	2012-10-02 22:59:21	2010-11-15 17:08:39	1	19	2411	47	796	9816	1092	126.00	21	48.77	CHANGED	clRtls.ps-..hcphhpLhphsFphspsth............p.h.phhpthhc......p...s...p.shshh-.....ssc....lluphthhshplsl..G.phhth.uulssVuohPpaRp....+Gl....hppLhpptLpphcpp.utsluhLhP...hp.h...shY.c+aG.aphs	....................................................................................................t..t-....ht.th....t....p..l....h...p......t....u......F.tsstps.......................................h..t.t.h.p....p..t..h.t..............................s........h...s.....h..s...s..h.c...............psp.............l..l..u..p..l...t.............h...............s..........h.......................h............p...........h.....p.......G.....p.....p......h...........p..........h.....h........s..........l..u...s.....l....u...V..t..Pc..a..+t........pGl....up.pL...l...p...ps....l.c...p....h....p.......c....t.....G.......h......s........h..s......h...l......h...u..........s...s.......s..a..Y..t+aG.ap...........................................	0	278	537	676
+13370	PF13528	Glyco_trans_1_3		Glycosyl transferase family 1	Coggill P	pcc	Jackhmmmer:B8J061	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.72	0.70	-5.24	39	1194	2012-10-03 16:42:30	2010-11-15 17:29:34	1	27	910	0	454	4822	1304	259.50	16	66.89	CHANGED	MKILYGVpG.o...GsGHlsRuRslsctL..+..p..H..-VchlhSG.Rs.t.chh...p..c.F..s.........hpph.........pGlohss.ppu...+lsh.........hcThhps.........thscthtphhp.hl..-hpp..hDLlIoD.FEPl..........o.u..hAA.....+hpslPsluluHQhAh...p.asls.ht....hss...hh...t+hhlpt...auPuphplulpaa........cap.ps.l.hPPllcpplhstp..s.t..p..t..st.lLVYLsh-shc.....pls-hLpt.hs....phpFhlY.Ghs.....p....-tp.......puslp......a+shocpsFhpDLtpCsuVlssuGFpL.uEALpLGK.lLhhPlc.G..QhEQp.NAhhLcpLGhGhs..h.sL-sshltcaLpph.......s	............................................................................................................................................................................................................................................................hh.h.h.h.p.s.....G...G.H....hsRsh.s.ls.p.t..L....p..t............h.........p.l..h...h..h.....s...s....t............phh......t....t...h..........................hh..th...............sh.............tt.t........p.hp................................t.t.h..h..............................t.........h..t.....t..........h.p..hl....pt.t......D.l..l.l.sD...h.....h.................h...h....hhs..............p..h........s.....h.....s....h..l.....h....l..s..p..........h........................................................................................................h...................................................h.....................................................................................h...h....................................................................................................................................l...h....h........hs.......t.t......................th.h.t.h....h...t....h..........................h....h.....h..h....t..............................................tplp......................hh...h....p..........t.h....p....h.....h.....t....t....s....p....h.........hlst.uGhp.....h...Ehhhhsh..h.l.h.h.P..h...........t....-...Q.....p.u.....h.t.th..uh..h.............................................................................................................................................................................................................	0	155	304	384
+13371	PF13529	Peptidase_C39_2		Peptidase_C39 like family	Coggill P	pcc	pdb_3erv	Domain	\N	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.15	0.71	-3.83	127	2151	2012-10-10 12:56:15	2010-11-15 17:30:24	1	145	1292	1	439	2081	233	142.70	20	40.19	CHANGED	lsVPhhtQh......s..p................h.sG..CtsToluMlL.....sah....Gh...s...hstsplApp..h.t..pss................t..tsahss.h.....ts....sh.ushs.tsl.tp.hup.pas........pshshsspsh......splh.ptlps..GpPVlshss..ht..................phsh.....ssHhlllsGYcp......st.......lhlsDPh	.............................................................................................................l.hhtQ........t....................................h.ps.CtssShsMlL..............pah.........Gh.........p............ls.t...t.p..l..sp.p..h.h..pts.................................................................hh.tp..............................t....ush.....ts...h...sp.hsp..pas....................................pshs..h..s.st.sh...................ps..l.t..ph.l.s.p.....G.p...PVlh.hh..s......t............................................t.h.st.....ssHhhl.lhG...Y-p................pt...........hhltDP............................................	0	190	306	388
+13372	PF13530	SCP2_2		Sterol carrier protein domain	Coggill P	pcc	Jackhmmer:B8J1N3	Domain	\N	25.00	25.00	25.20	25.30	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.20	0.70	-4.96	41	1071	2010-11-15 17:31:58	2010-11-15 17:31:58	1	4	843	39	229	841	26	209.70	22	53.40	CHANGED	spsGslsRsptWWcph.h.......t.........tttsc..h...p...hslahstsspspGYlhYchps..........sshpVp-hhussstAtpuLWpFlpuhpshhpplp.h.pp.ss--.sl.h..hLsD.P.cs.sp...........p..l..p..sahhsRllDltpsLpuh.sass...........stslsLpVp.Dshhsh.....NsGpapLph.ssGsssspps.........s...ps.s-lplslssLuslhLGspssspLsthGcl.c.....tps.sAlppl-p.lhss.c.p.Pah.-	.............................................................................................t..tGslhRsthhW...p.h.h.......t.........ttt.pp..h.....p.hslhhstst.cs...pG...Y..hh..Ypltp.............pphplpEh.hhhst.cA.ppuLap.Flsu..h.shlp...plp.h.ph.....sc....sL.h..hlp-..s.ch...pp............................p..h......p...shhMsR......IlD.VpthLp...th..sapt......................ptshslclp.Ds.hh.h.....NsGhaplsh...ts.......u......p.......sp.lsct.............................s........ts..sslplslpsLsslhhGhtp....sppLstht+l..p.......ssp..ptlpt.lcp..hhst.t...shh...............................................................	0	85	172	207
+13373	PF13531	SBP_bac_11		Bacterial extracellular solute-binding protein	Coggill P	pcc	Jackhmmer:B8IY91	Family	This family includes bacterial extracellular solute-binding proteins.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.52	0.70	-4.73	225	7719	2012-10-03 15:33:52	2010-11-16 11:58:06	1	25	3267	36	1791	14857	3154	235.70	22	78.01	CHANGED	lpl..hs..uuuh..ptshp.c.l.sstF.p.p......c....su........h.......p..l..plp....hu..so.....ut..lhp.....pl...........ppG..t..............s.....Dlhh.s..........us...phhpp.L.hpp......Ghst..............s.ttsh..sh..s.p....lslhs.tps.s................s.....................h....s.......h.p........s......h.p.s..........Ltp....s.............................sl.......+.....lu..husP....p.....s..sshGt............huh.phh..p...............ph..........................G..........................lhpplp.sp.hl...h..ssss....................pp.shph..........lt.p.G..p.....s.D...h.ul.s....h....to...ts.......................h...........ss..t.lph........l..l.Pssh...t................................h..thshulh..p....pu....tp........p...sA.psF....hpaL.tS.sp.upsl.h.pchGap	.........................................................................................................................................................................................................................................................l.s.sssh...pp...shp...p.l.s.pta.p.p.......c...ss...................lp..l....p.h.s......a.u....u.S......up......hs.p.......pl..............................tpG..t............A.................D.l.hh..s..................................As...t....p.t..h...s.t...l....t.cc........shlt......................................ss.sps.h......ht....s..s...........l.V......l...l...s..pcss................................s....................................................p......s.........l.p.........s..........h..sD.............Lhc....s.............................................sl.............c......ls......h.s...s...P......c............s....s..s.s.Gp...................hu.h..t.h.h.p...................p.h.........................................s.........................................................h..h........p..p..l.t...p.p....ls..........h.....s.s.ss......................................+s..shsh..................lp...p...G....p............u.D......l....h...l....s............a.........p.o....-u....................................h...............tss.....ph.c.l.................V.....h....s..p.....sh.......h.....................................................................sl.....p..h...s.....s....u....l.l...c..........ps.............tpp........p.tA...csa....lc.a.L.h.S.sp.u.p.p.l...h..tchta.....................................................................................................................................................................................................................................................................................	0	472	1088	1474
+13374	PF13532	2OG-FeII_Oxy_2		2OG-Fe(II) oxygenase superfamily	Bateman A	agb	Jackhmmer:A1B8L5	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.47	0.71	-4.48	71	3255	2012-10-10 13:59:34	2010-11-16 16:25:36	1	66	1836	23	1480	2897	465	187.80	22	55.86	CHANGED	G.hhhl.sal...s...t...p........p...hhphhpplh....p.pss....h.pp..th...t...Gpt.h...sl..........t.h....h....h....tthuW.........hs..........ct..t..sYcY....sstp......shsspsasshPthlhplhpchst.tt...................hs.s...hsP...sssLlNhYs.s..........uu.phGhHpDc-.Eh.....shssPllSlSLGssshF.........................................................ph....t..........................stp..css.....................spplhLpsGDlllhuGs..u..Rhta.Hulspltp.s.............................................t..................................ht.ssRlNLThR	..........................................................................................................h......................................ht.h.......t.............h..p....h...............h...................................................................................h.th........................hs..........................t....tY..pa......ss..h.................................p...st...s.h.s..s..h.P.t.....h.t.p.lh..pphtt.............................................................s..h.p.....s.ss..LlNhY.p..s....................Gs..pluhH..........p.Dpc..ch............sh.p.ssIs.S.lS.L......Gss.shF................................................................................................................ph......t........................................................................thp...pss....................................................hhplhLp.p.....Gsll.lh.sGp..s....phta..Hul..hpt.s...........................................................................................................................................................htstRlsLTFR..............................................................................	0	460	838	1193
+13375	PF13533	Biotin_lipoyl_2		Biotin-lipoyl like	Coggill P	pcc	Jackhmmer:B8IZB1	Domain	\N	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.73	0.72	-8.24	0.72	-4.30	99	2242	2012-10-02 20:27:15	2010-11-16 16:33:40	1	39	1526	0	592	25272	6066	54.60	29	15.15	CHANGED	ps..........lsl.s.spl..uG.tlspl......hVp.-sp.hV+cG-lLhpl-s.sphp........hthpp...............sps..p.......l..t	...............................p.....tl.s.ssl......uG..hl.spl....................................Vc..-..s.Q..hV+KGpl.L.h.p.l.Dp...schp.....................ttlpp............................sptt...................................................................................	0	178	334	468
+13376	PF13534	Fer4_17		4Fe-4S dicluster domain	Coggill P	pcc	Jackhmmer:B8J3I4	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.76	0.72	-3.62	126	4064	2012-10-03 08:56:43	2010-11-16 16:34:27	1	53	2739	54	1193	12425	4526	71.60	29	15.95	CHANGED	tChpC..s..h..Css....................Cs......h..............hhh...........hs.t.......t..........sp......p..hhpph.....th..............s....hh.p.p.......h..t.t........p......t.h...ppCstCGh..Cp..htCPt..sls	.............................................pClhC.u..t........Css..........s.............CP.....o....................................ahh.....................ss.c..........c...................................ss.......s..l.h.t.t.h...phh.............................................ts..ph.p..t...........h..pp..t.................h........pl....pC...tsshs.........Cs..psCPpGls.................................	0	417	815	1025
+13377	PF13535	ATP-grasp_4		ATP-grasp domain	Coggill P	pcc	Jackhmmer:B8J4T0	Domain	This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.16	0.71	-4.55	109	4886	2012-10-10 13:17:03	2010-11-17 14:52:06	1	70	2718	6	1546	35532	13206	172.70	17	35.99	CHANGED	th+.cKhth+phhp.ttGls.sst.......thhlpshsshpthhpth........h....PhllKPtpu.su.....S...hslhh...lp...sts-lpsh..hpphttph.................tthllEpals............G...s.asl-uhhh....cGch.hhhsstchhhs.s.ph.....h.hsth....tt.......tthpphspph..lpsh.uhp..pGshHhEhhhssc.G....hhhlElss.Rs.uGsth	.......................................................................................h..psKhhhp.c....hhp...p....t..G..l.s...sst.......................................t.t..h...h......s......s......h........p.......p.....h.......t.....p.....h......h...p.p.hs.............................h...........P...l.l.lK.......P......t....s......u...su...................u...........tu.l...hh.................lp...............s.t.p..-....l...p...p.h.....hp..p.hh.tttt........................................................................thl..lE.c.a.ls..............................................G.......pp...h.......s....h........p....s......h..........s...........sG.........c..........h.........h........h........h........s......h.....t.......p..........h........h....h....t.............................h........................h.s................................................ttl.h..p.h.s....t....t.h.........h.p...t...h....s.h....................u...h...h...p...h...-..h..h.....h.........s........t.......p....s.....................h.h.h..Ehs..R....t............................................................................................................................	0	543	1039	1334
+13378	PF13536	EmrE		Multidrug resistance efflux transporter	Coggill P	pcc	Jackhmmer:B8J0H9	Family	This is a membrane protein family acting as a multidrug resistance efflux transporter.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.59	0.71	-3.88	52	1585	2012-10-02 19:55:49	2010-11-17 16:30:08	1	10	1267	0	447	11223	5450	114.20	18	37.49	CHANGED	AulR...ah..hhhhhhhlllh...h...+t..p...lt..........p....h.hp..th+p...pshh......h....hlhhuhlGhslh...hshhshusph.....u......s.u.hls.s...h.ht..h..sslhsslluhhhh....p.....p...chst+............tllhs.hllhsGl..hllthpp.h.tu...hs	..................................................................h..hp.h.h...h...h..h.h..h.h..h..h..h........h.....pt......p.....h.t..............................t....l....hp......t..h.pp.......p..hh....................h......h..l..h..h..u..h..l.s.h.........ht.....hhhh..h.hA.hth....u...........s..u...hlu...sh.ht..l..ssl.h.ssLluhhhh.............+.........c............+.ls.h.t..................................................ph..l.u.s.hl.hh.h..Gl.hh.hth.......tt..................................	0	132	261	374
+13379	PF13537	GATase_7		Glutamine amidotransferase domain	Coggill P	pcc	Jackhmmer:Q2LTR9	Domain	This domain is a class-II glutamine amidotransferase domain found in a variety of enzymes such as asparagine synthetase and glutamine-fructose-6-phosphate transaminase.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.60	0.71	-4.39	568	6228	2012-10-03 21:14:07	2010-11-17 16:30:36	1	28	3641	10	1948	11436	7426	122.40	33	21.85	CHANGED	HpRLul..........ssGpQPhh........t.ssp...hs..llaNGEIYNa....p-LRp.-Lt..s.t..G.....a...p..F..p.o.p.SDTEV.lhthhtt.................aGpssl.......p+LsGMFAFAla..D....p..c..pp....pLhlARDRhGlKPLYYsh........p.......ut....sl....hFuSElKALls	.....................................................................tRLul....ss..tt..u.tQPhh....t...............t.st..p..........hsls.......aNGE.......lY.........Nh..........ppLR...p...cLt.....p..p......G.................h......t...F......p.....o......s......S.....D......o.EV....l.l.thhpc...............................................ts....t..csl....................cc..l.........p..G..h..FA.F.s..l.h.D...........p.c.pt......tl.h...h.uR.D.hGl.+.PLahup..................pp........ss.....sh......hhuSEhpAL....................................................................	0	640	1243	1641
+13380	PF13538	UvrD_C_2		UvrD-like helicase C-terminal domain	Coggill P	pcc	Jackhmmer:B8J482	Domain	This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.48	0.72	-3.89	132	6202	2012-10-05 12:31:09	2010-11-17 16:43:43	1	104	3952	12	1430	12988	3540	110.90	23	15.99	CHANGED	hths-thlhhhsshpp....................tlhsspltph...tpht.........pttttlpt............................................hsasholH+upGuEassVhlstsstt...ht..........htpch....LYTAlTRApptlhll	..........................................................................................................................h...uc.lh.hhNs.th...................................slhNG..slGhh..h.t.h......t...................................t.t..h.ht...................................................t......p...........................hphuaAhTl.HKuQG.SEFst..Vl.l...hh..ssth..........................................................hhp+pL.........lY...TAlTRA+cpLhl.............................	0	456	937	1217
+13381	PF13539	Peptidase_M15_4		D-alanyl-D-alanine carboxypeptidase	Coggill P	pcc	Jackhmmer:B8J0M5	Family	This family resembles VanY, Pfam:PF02557, which is part of the peptidase M15 family.	25.00	25.00	25.10	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.91	0.72	-3.53	215	1064	2012-10-02 01:02:30	2010-11-18 11:18:06	1	38	858	0	257	963	223	71.80	28	28.71	CHANGED	su.sst..hSpHs..........aGhAl......D..ls........shh.hstp......................................................................thstspp..ls..p.hhtp.........hG....tWGGc.W...............h..h..Dh.HFph	........................................................tts....tp..pStHh..........h..GhAlDls.......t..s.hlt.h.ssp...............................t..............................hphst.h.pp..hs..p..hhpp......hG..h..p....WGGc.W..............................p.....sh...hDt.HFph..................................	0	109	185	224
+13382	PF13540	RCC1_2		Regulator of chromosome condensation (RCC1) repeat	Coggill P	pcc	Jackhmmer:B8J0U2	Repeat	\N	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.26	0.72	-4.24	320	3569	2012-10-05 17:30:43	2010-11-18 13:23:35	1	413	646	32	2155	12729	3878	29.90	34	6.54	CHANGED	l..s..p....lu...s..G.t.tH.....shu.Lp.s....s.Gs.......lhsaG..s..N..s..tGQ	.......................hht.lu...s.....G..t..tH....................ohu.Lp.s.......s.Gp..................lhsaG.....p...N....p...hGQ...........	0	959	1559	1984
+13383	PF13541	ChlI		Subunit ChlI of Mg-chelatase	Coggill P	pcc	Jackhmmer:Q2LRR9	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.31	0.71	-4.59	173	7224	2012-10-03 01:04:38	2010-11-18 16:46:55	1	17	4260	0	1657	8626	2674	111.30	31	23.71	CHANGED	VEVcl..u...sG.L...Ps...aslVGLP-sAV.KES+...-RV+oAlpN......oGacaPsp+ITlNLAPADL+K-GutaDLPIAlG..IL......u..u.....p...t.p...h..s..t..h...........p..p...hh...h..lGELuL-GpLRslpGsLPhsl....tA.p.ctu.h.+p.lllPtpN	........................................................................................................................................................t................sGh...t.......h.......s.......s.....p.....c.....l...h.............lN......l..s...........s.u....s.......l...+.hs.....tsuhDLulAlAll.......ou.....h..p..p....h..s..hs....................p..p..hhhlGEluLsGclR.....sVsu.s.pplt....EA.t.....+....h..G....a.c.p...hllPptN........................	0	556	1110	1418
+13384	PF13542	HTH_Tnp_ISL3		Helix-turn-helix domain of transposase family ISL3	Coggill P	pcc	Jackhmmer:Q2LSW8	Domain	\N	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.76	0.72	-8.06	0.72	-4.77	134	3356	2012-10-04 14:01:12	2010-11-18 17:14:59	1	11	862	0	381	2084	96	51.40	41	17.15	CHANGED	tpss.hlpctsphTpthcp...hlhphhtpp...ohpslActhsluhpTVpclhpchs	..................A-Ts.lV+KNpQIschlsQ...KIAQpLlE+..hSMT-IA+pLulSTSTVhRhLsca.p...............	0	89	236	288
+13385	PF13543	KSR1-SAM		SAM like domain present in kinase suppressor RAS 1	Page R	kellrott	NMR Structure	Family	\N	27.00	27.00	28.00	27.60	26.20	25.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.65	0.71	-4.35	10	142	2012-10-02 20:42:54	2010-11-20 00:12:54	1	6	79	0	70	133	0	111.40	45	15.00	CHANGED	hshlQcMIDISus+LcGLRTQCAs.Ss-LTQQEIRsLEuKLV+aFSc.LlsKp+lsEc.s...AstL.sY.....PcLpQWLcVVGLpscolpulhsplpTL-shLcMs-cEl+plLsc...spsp.EEEp+RLppAhpNLR	.................lQphI-lShspLpG.LRTpCuh.....S...ssLTQpEIRsLEuKLV+YhucQL.sKh+.ls.p.....sstL.sa............PpLppWLclVslp.-slptl...........s.p...h..oL-sLLchs-tcl+phlpc.....husp..pEEstRLstALpsLR...........................	0	18	24	45
+13386	PF13544	N_methyl_2		Type IV pilin N-term methylation site GFxxxE	Coggill P	pcc	Jackhmmer:Q2LVK2	Motif	This short sequence motif appears a the N-terminus of type IV prokaryotic filamentous adhesins or pilins. The N-terminal residue, which is methylated, is hydrophobic (generally a phenylalanine or a methionine), and this leader peptide is hydrophilic. The fifth residue of the mature sequence is a glutamate which seems to be required for the methylation step.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.49	0.73	-7.55	0.73	-4.25	777	9430	2012-10-03 10:38:27	2010-11-22 10:00:16	1	25	2209	25	2394	7502	2666	27.30	43	14.94	CHANGED	M...............h.ppppGFTLlElllulslhull	....................h.................ppppGFTLlElhlVlsIlulL.........	0	899	1563	2033
+13387	PF13545	HTH_Crp_2		Crp-like helix-turn-helix domain	Bateman A	agb	Jackhmmer:A1B3V6	Domain	This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.81	0.72	-9.15	0.72	-4.19	94	8343	2012-10-04 14:01:12	2010-11-22 11:39:05	1	18	3028	101	2466	7943	935	72.00	22	30.98	CHANGED	pR.lApaLlthtschst....................hpls.lopptlAphlGl.pR.ps.lopslppLpppGlIp......h.....p+.s.plplhDhptLpph	.................................................RlsphL..l.t.h..s.pp.hst........................................t.......hpls...loppcl...Aph...lGs.o+.po.lsRhLpchpcc.G.lI.p.......h................pp...p.pl.tl.hchptLtt.h......................	0	769	1663	2072
+13388	PF13546	DDE_5		DDE superfamily endonuclease	Bateman A	agb	Jackhmmer:C0W963	Domain	This family of proteins are related to Pfam:PF00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.69	0.70	-5.54	14	1337	2012-10-03 01:22:09	2010-11-22 13:29:01	1	10	331	0	429	1483	75	212.80	20	63.11	CHANGED	sLpphhspassh....Fspt..cpppthhthltGhlushpR+ol.tluh..hhutpssp....uhpchlspsca-tsplpttltp.shsph....sssptllslDsTshsKp.....Gp+osuVtRpasGshG..Ktpss.sslalh.sspth.pshlstplalP.ptWhps......t.+pphsslsss.hapsK.plAtthlcphhtsu.h.hth..lssDutYu.tcttFlptLpptt.hthlsplpsspshahtsst.ts.......pGRPthhs.h.....hslpssplh....phhspsapphsh+ttsKG.	..................................................................................................h....................h.t...........t..t.h..hh....s.....hh......tp.+s.h..hut......h....ht..t.t.t.....shpph.lspsp...as.t.t.lht...tlht.h..h...h.............ttttt.h....hhlD-osh...Kp......G..h..po.s....sl.s.+...p..a..ssph.G......+.......h....t....p.s.....hs....l....h....hs.......st........t....p...h.l..shp..l.h.h.P...t..thhtt...........................cp.pts...th....p...p.....h..h...t....s..K......t.....lsh.t...lpp.h..ht......t..h..t.h...lluD..uhYu....pt..th...h...t...h.pp..h...s...h.....hhhtlp.psphh..h............................................................................................................t..............................................................................................................	0	104	270	331
+13389	PF13547	GTA_TIM		GTA TIM-barrel-like domain	Bateman A	agb	Jackhmmer:A1B6L4	Domain	This domain is found in the gene transfer agent protein.  An unusual system of genetic exchange exists in the purple nonsulfur bacterium Rhodobacter capsulatus. DNA transmission is mediated by a small bacteriophage-like particle called the gene transfer agent (GTA) that transfers random 4.5-kb segments of the producing cell's genome to recipient cells, where allelic replacement occurs [1]. The genes involved in this process appear to be found widely in bacteria [2]. According to the SUPERFAMILY database this domain has a TIM barrel fold.	27.00	27.00	27.00	27.10	25.80	26.90	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-12.00	0.70	-5.43	66	218	2010-11-22 15:16:03	2010-11-22 15:16:03	1	5	195	0	83	214	30	265.80	48	25.22	CHANGED	WuYRRFILHYAtLst...u.....AGG.V-uFlIGSEh+GLTplR............suss..uFPAVstLtsLAu-VRulL..........Gsss+loYAADWSEYaGapss-GsG-haFHLDPLWAcssIDFlGIDsYhPLoDWR-GpsHhDAt.......................thsulaDhsYLpuNlpGGEGYDWaYsos.........tsRsAQhRoPITDushuc.......PWlaRhKDl+sWWsNsH...a...-RsGGVctusPTuWlPpSKPIWFTEhGCsAVDKGsNQPNlFlDPKSSEStlPhaS..........sGtRDDhhQppaLcAhlsaWs......s......sspNPsSslYG....GtMlD.schalWsWDARPaPtFP	..........uYRRFILHhApLsh...t.......AGG..V.DAFlIGSEh+GLTplR............ssts..saPhVstLpsLAu-lRulL..........G.sss+loYAADWSEYauapstsGsG-hhFpLDPLWAcssIDhIGIDsYhPLoDWRDustp.ss........................thts.aDh.shLptsltuGEGa.DWYYsos................tsRtAphRsPITDGhhuc.......PWlaRhKDl+sWWsN.Ha......sRhsGlc.us...........sTuWlPpSKPlWFTEhGCPAVDKGsNQPNlF.DPKSSEsthPhaS..........sGtRsDhhQcpaLcAhhpaWp......s...pNPhSs.lYG....G.Ml-.pchalWsWDARPaPtFP.............................................	0	18	58	68
+13390	PF13548	DUF4126		Domain of unknown function (DUF4126)	Coggill P	pcc	Jackhmmer:Q2LV71	Domain	\N	27.00	27.00	27.30	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-10.88	0.71	-4.84	52	380	2010-11-22 16:08:38	2010-11-22 16:08:38	1	3	355	0	157	366	68	174.00	31	86.32	CHANGED	slhLuhGLuhAuGlplYlslLhlGl.hut.hGh..lsLPss...h...phLssshslsssulhhllEhhADKIPsVDslhDslpThlRhsAGuhL.sAu..sh....uc...hsP..sh..........p..hshAslhGGuhAussHus+uusRsslNsostsluNslsSssEDssslsh.hlAlhhPllhlll...ll.......lh...l...lhsh..hhlh+lh	......s.lhluhGLuhAuGlRl.a.lslLhhGl.hut..hGh.........l.p.LPss...h........p.hLssshVlsshulhslsEhhADKlPhlDohhDslpThlRhsAGAlluAu...sh.......up.....hsshh.............t..h.hAslsGGsh.Asss+hs+u.usRshlssostshuNh..lsShsEDshsluhhhlAhhhPllhhll.hl.......hh....l.......hhsh.hhh.p..h.......................................................	0	44	105	139
+13391	PF13549	ATP-grasp_5		ATP-grasp domain	Coggill P	pcc	Jackhmmer:Q2LV27	Domain	This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	222	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.14	0.70	-5.13	220	2119	2012-10-10 13:17:03	2010-11-22 16:09:47	1	27	1555	1	765	4111	1934	216.30	36	28.42	CHANGED	pAlsc..u..Rsh.LsphEuptlLsAYGIsss.tohl...Ap.ospEAsthAppl...G.aP.VslKlhS.....Pc...Is.........H.........KoDlG...GVtLsLp.ssppVcpAhpplhppl..ppth.........P.s..........................Ap.l.pGlh..VQpM...sp......tupElllGsspDPhFGPllhFGh.GGshVElhpDt.........uhsLP.P..........Lsh.slAcc.h.l.pps+st.plLp.G..hRs..p.P...sD.........hsALtphLl+l....SpLls.....D.h.Pc........ItElDINPLls....ss....p........G..shAlDARltl	..................................................tt.tt...Ls..ptEsp.s.lLpuYG...lssh.sshl............As.ss.sEAlp..hAc.pl..........G..a.P.....V.s.lKlhS..........Pc.......Is.........H.......................KS.-...l.s.....GV.hL.......s..Lp...sspc.Vp...p.Ah.ps.l...h...s....p....s....phh.h........P.p.......................................Ap....l..c....G.lL....V.Q.pM.....ss.........sutE..Lhlu..l..p..c.D..P...s...F..G..P..l..l..h.h..G.....GGl.h.s-.h.h..c.Ds............s.h.t.L.s.P............Lsh....s...A.c...t....h...l....pp..l..+..st.......c.....l...l..t..u.....h+.sp...s....lD................l.s.u.LsplL.l.p.l....Sp.Lls.......-.t..P-...........I..p..c..lDINPLl..s..ss.......s.........t....hsAlDspl..........................................................................................................	0	255	518	663
+13392	PF13550	Phage-tail_3		Putative phage tail protein	Bateman A	agb	Jackhmmer:A1B6L4	Domain	This putative domain is found in the large gene transfer agent protein. These produce defective phage like particles. This domain is similar to other phage-tail protein families.	21.80	21.80	21.80	22.00	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.60	0.71	-4.47	106	1924	2012-10-01 22:58:23	2010-11-22 16:42:01	1	32	968	0	203	1978	371	159.10	38	15.89	CHANGED	sp..pss+sslpsLhpsashsshpps.uplph.htc..s...................s.ps.s..hsl.stsslstssp..t.........t......hphs....Rssps....-hssplplpah-ss...ssYpsss...sp.utp......s...s....sts.....tthsshphshshs.....pspApplupphLtpstsspcs.hpasls.pt.ht......lp..PGDllp.ls...s.................s...p....st..thRlspl...c....p	....................................................................pppcAa-VLsDhsushR.shs..lWsG.p...s...Lsh..lpD..t...................s.-h...V...asa..spusVVhs-p.t...............FcYo...ho.uh.+....DR.asuVcVsa.....hDPs.....Nuapsus.......EhVcD.........s...p......ultR..............hGcNhtch-A.aG.CTS........RGQA+....RsGhWllcTphhEspT.VsFolGhcG.lp......hs..P.GDlIc.lsDst..............huG..h....thuGRlhul..s.....................................	1	37	114	158
+13393	PF13551	HTH_29		Winged helix-turn helix	Coggill P	pcc	Jackhmmer:Q2LS51	Domain	This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.55	0.71	-3.92	85	3523	2012-10-04 14:01:12	2010-11-22 16:50:17	1	49	1390	0	1218	5925	803	103.40	18	36.88	CHANGED	RtpslhhhspGh......tssphuchhul.sppslh+hhcpap.ptG...hsu...Lhs...ptp..tspspp....lsstpcp....tllp.hsp.ppssp....G........shhohphltp.l...........hshplStpslpphlp+.tu	...........................................hlhh.h.tp.uh...........hpph..uchls..l...upp.ol.h+ah......p.p.ap..ptG.........hpu.................Lhs......pt+......ss.p.spp......hstp...hpp..........tl.h.p..hhp.pps.t.....s...................ph.o.h..p.hl..tp.h.....................s..h.t..l..u.....ps..l.tphhht.............................................................................	0	289	753	1056
+13394	PF13552	DUF4127		Protein of unknown function (DUF4127)	Bateman A	agb	Jackhmmer:C0WER5	Family	This family of uncharacterised bacterial proteins are about 500 amino acids in length.	27.00	27.00	46.40	46.20	17.60	17.30	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.60	0.70	-6.10	50	186	2010-11-22 16:53:42	2010-11-22 16:53:42	1	4	127	0	59	185	2	426.60	27	92.87	CHANGED	+llalPLDsRPsshpash.luphs.shpllsPPpchLushppsucs-tLtpWLppp.s..ss-shllSlDtLlYGGLlsSRppphshcpshpRLphL+pl+ppsPshpIYAFslIhRsst.s..sspp-PtYa...tpYGtplaphuh.......hhD+.t....hs.ppttph..tplpttlPtchlpDahs+RpcNhplNtthlcLsc.cGllcaLslspDDss.auhsshEpcpLtphhpphsl.tp+...............lhhaPGADElGhsLluRshsphtt.p....PplhlhYsssputphls.YEspslpcolpp+lpuuGuhhsss.ppADhlLhVsssstttt......tt...........pshpphsppIpphlsp.GcsVulADlAasNGuDppLlphL.tctshltcLtuYuGWNTuuNolGoulApuhlthth...............stpsphphLhtRhl-DahYQusVRsplp..cphtt.....shshhslscpptt.............hpphhpp.......hhpphhtpphshphhthph..............phPWsRhFElslpl	..................llalPlDsRPsshphsh.huphs.shpllsP....Ppphluth..........pps.............ussptlhpWl.pp.ht.pscshllShDhLlYGGLlsSRhpph........s.pph..........t+h.phlcpl+ptpsph.lYsFshlhRs...s..s....sst.-s...aa.tas...tlh.phuh.......l.c+.t.....t.ht.t-ttph...ttlpttlP..phlpcaht+RppNhtlNpthlp.hsp..pGhhshL..slspDDss..hu.ssh-...tptLtthhpp......ht....pc................hhhhsGADEluhhLlsRhhsch...t.h....PplhlhYs.stutthls.YEs.t...sltpolptpltusGuhhsp..tpuDh.lLhlpss.......................................................tshtthsptlpphltp.sh.lulsDlu...hsNG...u-ttLhthL..pts....h.......l.cltuYuGWNTsuNolGhslupuhlhhhh........................s.ttphphLh.chl-Dah...Ypu.lRpplt.pth.t......t.s.hth.t.pttt.t.............hpthhpp......................................hpphhtt....hh...h........h..ph.......................phPWpRhFEhphp.........................................................................	0	21	38	55
+13395	PF13553	FIIND		Function to find	Weichenberger CX, D'Osualdo A	kellrott	Joint Center of Structural Genomics (JCSG)	Family	The function to find (FIIND) was initially discovered in two proteins, NLRP1 (aka NALP1, CARD7, NAC, DEFCAP) and CARD8 (aka TUCAN, Cardinal)\	  [1]. NLRP1 is a member of the Nod-like receptor (NLR) protein  superfamily and is involved in apoptosis and inflammation. To date,  it is the only NLR protein known to have a FIIND domain. The FIIND\	domain is also present in the CARD8 protein where, like in NLRP1,  it is followed by a C-terminal CARD domain. Both proteins are described\	    to form an "inflammasome", a macro-molecular complex able to process  caspase 1 and activate pro-IL1beta [2]. The FIIND domain is present\	in only a very small subset of the kingdom of life, comprising  primates, rodents (mouse, rat), carnivores (dog) and a few more,\	 such as horse. The function of this domain is yet to be determined. Publications describing the newly discovered NLRP1 protein  failed to identify it as a separate domain; for example, it was taken as part of the adjacent leucine rich repeat domain (LRR) [3].  Upon discovery of CARD8 it was noted that the N-terminal region  shared significant sequence identity with an undescribed region in  NLRP1 [1]. Before getting its final name, FIIND [4], this domain  was termed NALP1-associated domain (NAD) [5].	27.00	27.00	28.40	28.10	24.30	24.10	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.61	0.70	-4.95	7	140	2010-11-22 18:21:59	2010-11-22 18:21:59	1	31	32	0	69	160	0	224.30	41	24.92	CHANGED	RV+hPsAGoYphPsTGLtFlVpcsVTl-IcFCu..WsQaLc.ch..pcsWhVuGPLFDIKAEP.GAVsulaLPHFluLpsGcVDs.ShFpVAHFK-cGMlLEpPsRVE.aasVLEsPSFSPhGlLLRhlsushh.lPlTSssLlYa+l.a.E-lsFHLYLlPsDsslpKAIDDc..EhKFpFVRIpKPPPlssL..hGuRYlVSGS..spLEIhPcELELsYRSPGE.QlFSEhYlGphtssI+Lplp-K+atsLVWcALlKPsDL	......................................................................VphPsAGpYphssTGLtFVVppsVTlcIpFss..Wspa.Ls.ch...ppsWhVuGPLFDIpA.Es..sAVsslaLPHFlsL.p.s..u.cVDs.ShFpVAHFp-cG.MlLEpPu+VcsaasVL-sPSFS.hGlLL.+.hhpushh.lPlsShsLlY.a+h.......p.--l..p.hHLYLlPsDsslpKAID-c.......E.+F.phl+lppsPPhp.s.L..hGs.cYhVSss.......t.lc.lhP.p.E.Lc..LsY+Sstc.QhFochahtphtp.IpLplppp.....pp.sllWcs.l+ss........................................................	0	20	29	43
+13396	PF13554	DUF4128		Bacteriophage related domain of unknown function	Wahab A, Serrano P, Geralt M, Wuthrich K	kellrott	Bordetella bronchiseptica RB50 PDB:2L25	Family	The three-dimesnional structure of NP_888769.1 (PDB:2L25) reveals\	     a tail terminator protein gpU fold, which suggests that    the protein could have a bacteriophage origin.	27.00	27.00	27.00	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.35	0.71	-4.47	28	150	2010-11-22 18:52:35	2010-11-22 18:52:35	1	2	141	1	34	122	78	121.30	22	89.05	CHANGED	tIppulct+lsphs...tt...sl.lAa.NlsFssssut....sYLpsthhPusTpshsLutct.phhpGlhQlsVlhPsGpGsstspplAspltstFtsspplppsshtlhlppsPphussIssssphplPVolpY	................Ipthl.s+ls.s.hs.....tht..shs.lsa.Ns...s...........Fssssst....halphphhsusotshslu..t..ss...h..hhp..GlhplslhsPsGsGssthppl.AcpLtphFp.....th...s.....h.t..........t..............h.hshph......................................	0	3	18	26
+13397	PF13555	AAA_29		P-loop containing region of AAA domain	Coggill P	pcc	Jackhmmer:C2M2Q6	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.25	0.72	-4.44	68	804	2012-10-05 12:31:09	2010-11-23 10:58:31	1	6	755	0	192	5015	2079	55.80	31	5.90	CHANGED	LpclpllNWGoFcs.cshs..ls.tG...s..sLloGssGSGKSTllDAlpslL..sPsp..t.h..tFNpA.A.sss	......................................apt...p.hs.....h...s...p...t..G.......h...hlIoGs.oGoGKSTllDAlp.hh..L....hsps.................t.........................	0	60	123	166
+13398	PF13556	HTH_30		PucR C-terminal helix-turn-helix domain	Bateman A	agb	Jackhmmer:D3Q4F0	Domain	This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.48	0.72	-4.38	456	5435	2012-10-04 14:01:12	2010-11-23 15:02:24	1	29	2226	4	1399	4584	150	58.40	30	14.07	CHANGED	L.lcTLcsal.pss.tshspsAppLalHpNTlpYRLc+lpclhG.hc.lp...s.sps....th.pLtlAlpl	..........................LhcTLpsa..h..pps..sshspsAcpLalH+NTlpYRL..c+lpcls..G.hs.lp....s..hcs....th...lhlAl..........................	0	544	1037	1249
+13399	PF13557	Phenol_MetA_deg		Putative MetA-pathway of phenol degradation	Coggill P	pcc	Jackhmmer:Q2LTI1	Family	\N	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	248	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.95	0.70	-4.57	154	1206	2012-10-03 17:14:37	2010-11-23 16:08:22	1	10	655	0	439	1221	272	237.20	14	76.57	CHANGED	uspssssp.....Gppls........shchph...pssh.phhhhp.s.p....h.hss..thuhthh..l.s.hh...phph.phs......t..........hpss..t.....G.huDhhlushhhhatp.t..........shph.......shthtlthPsGsasts.ps......s...........shhshssphuhs...hs.s.thslssshthsh...tscsss....................phptt.sthphshshsh..t...h.st.....ph.ssGltua.hh..............t..s..........ts..sctpshslGsulsahhsts....hplshphtpph....sspsthtussh.hh+h	..............................................................................................................thth..........h...th.h...............tt.....phsh.phh....l....hh.......phph..ths........t...........................................http..ts................G.hGDltlushhhhhptst...................shth..............................shthtlphP.T..Gshsts.p...........................ut................shash.ssthuhs......ht.......s.....ths.lssph.thth..............ttcsss.....................phptu.st.h...phshshsa.......t.l..ss..........ph..ph...ulssh...hh.........s..................p..s.t...........ss....sctpsht..lss..uhtathstt..........hplphphhhsh........sspsh..t..h.........................................................................................................	0	137	262	362
+13400	PF13558	SbcCD_C		Putative exonuclease SbcCD, C subunit	Coggill P	pcc	Jackhmmer:C2M2Q6	Domain	Possible exonuclease SbcCD, C subunit, on AAA proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.25	0.72	-4.07	152	3904	2012-10-05 12:31:09	2010-11-23 16:14:37	1	21	2832	14	954	3276	186	85.50	31	7.53	CHANGED	pphhDhRsa.hs.aplphp....pts.........u.ppht...h...hpshsshSGGEpthhhhlsLtAAluthh..st...........tss......hchlhLDEAFuphDscphppshp.hhpp	........................................h...........t.hplph.......p..................s...tp......h..........h+pstsLSGGEs.................hhsuLsLu..LuLushh..pp............shs.................hchLFLDEuFusLDs-olcssh-sLc.t..........................	0	313	591	808
+13401	PF13559	DUF4129		Domain of unknown function (DUF4129)	Bateman A	agb	Jackhmmer:D3PZP2	Domain	This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.43	0.72	-4.01	194	1189	2010-11-23 16:26:06	2010-11-23 16:26:06	1	12	838	0	462	1144	159	72.80	18	14.34	CHANGED	ptapthhp.hhtpt.ulspp...s...upTspEh....spcs....sttt.........t..lpp..........lsphacps+Y.....Gscs.sstp.ph......pphtpthcpl	..........................hatthhc.hhtph.ulshp........sucTspEh...spcs..............................spths.........ssshpp................lsphappspY............upps..sstt..ph.........pphhphht...............................	0	148	321	418
+13402	PF13560	HTH_31		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:D3Q8V6	Domain	This domain is a helix-turn-helix domain that probably binds to DNA.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.30	0.72	-8.90	0.72	-3.77	149	10133	2012-10-04 14:01:12	2010-11-23 16:28:26	1	174	2365	13	3830	31197	3989	66.80	24	29.09	CHANGED	pLGttL+p.hRp..ps..........................G.l.otp.plApths........h.Sts...plsclEp...Gcp...s.........shs....hlptls.ch.hs..s..s...........ss.....th.p..tL	........................................................................................hGttlRp.hR.p....p.t...........................G..l..opp...pl.A.p.t.sG................l..S....h.s.....hl.sp.lEp.......Gc.p.....s..............................oh.p..........hlt..t...ls....ps.Lt....l..s.......................hh...........................................................................	0	1127	2704	3367
+13403	PF13561	adh_short_C2		Enoyl-(Acyl carrier protein) reductase	Coggill P	pcc	Jackhmmer:C2M4X7	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.50	0.70	-4.60	47	22490	2012-10-10 17:06:42	2010-11-23 16:43:09	1	80	4615	768	7643	72809	33208	228.60	25	81.38	CHANGED	Gshs-pSIuWtlActht-pGApllloshs......................t...............................hh...stlp.plucph..s.....sc.....l.......l..shDss..st..-c...................lpplhpplpcph.......GplDhllHSIuhusp.t...htpshh-.s.shctahpuhslSuhSahslhpthh...hhscs......GSlluLoYlAupRs.hPsYs.sMusAKAuLEShsRsh.AhchGc.+slRVNsIStuPht.TpA.upuIss........h-p......hhpaupphuPLsp..s.su--lAsssshLhS-LsptlTu.pslalD..GGhs	...........................................................................................................................................................................us.....pGIG.h..u.h.A.....p...t...h...s....p.....t....G.....A...p......l...s...h...s...h.s.t.......................p................................................................................t..........t........h...p.....p...h.....h...p....p...h...s...............tp..........s..........................h..ts..D..l..s....st...pp.......................................................l..p..p...h...h..p...p....h...h...p..p.h.............................G..p..l...D..h....l.....V......s...........s.......A.....G............h............s...............................................s...s....h........h.............c............h.......s..............t...........c........t.............a.........p.............p...............s........h.....s.......l..........s...........l.......h..............u............h.....h.......h.....h....s.....p....t....s.hs..............hh.....p...p...s.................................G..u........I......l........s.......l.........o............S..........h...........s...........u............h............p............s..........h...........s..........s...........h..........s.........s...............Y.......u......s.........u......K.......A.......A......l.......t.............u.........h............s...+........s....l....A...h....-....h...........u.........s.................p.........G.....I.....R...V..N......u.....l.......u.........P.......G.........s..........l..........p......T..........s........h........h.....p....s.....h....h..t..................................h.p.p....................h...h...p.....t....h......t.......p..........p.......s.........P...........l.............t........R......h...........u......p.......s.........c.....-..l.......A..s..s...s.h..F...L.s.S....-.t.u..u....a...l.T.G.p...s.l.hV..D..GGh.......................................................................................................................................................	0	2101	4453	6315
+13404	PF13562	NTP_transf_4		Sugar nucleotidyl transferase	Coggill P	pcc	Jackhmmer:C2M1K0	Domain	This is a probable sugar nucleotidyl transferase family.	27.00	27.00	32.60	31.80	22.90	24.60	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.88	0.71	-4.58	35	114	2010-11-23 16:46:08	2010-11-23 16:46:08	1	3	114	0	61	123	80	160.00	28	39.69	CHANGED	phlLF--st.tppLhPhTaTRPVu-lRlGIhTl+EKWpphL.s.......ssp.s.ohhsccYL........pp+aP........sph.p.t-...s..........lhlNuphlPsc.tlsphIps..L....c.Gp..ul.hps-.....cllAhc....................h..cp.....schs.............sh.................ttlp....htpshhhlcpsWDlFshNsptlppDach.lo..p.GRsS	.....phlLFDsss.tppLhPhTaTRPVu-lRlGIhTl+EKWpphL.s.......s.ssohlTcsYL........ppKaPh.............sp..t..tp...s..........lhlNushlP.sp..tlhphlpp......L....p.sp...Alhts-........pllAhhhp...............tpp.ss.hs..............ph.................phlp....htpshhhlcpsWDlFshNsptlptDaph.lTpsR..............................	0	29	48	58
+13405	PF13563	2_5_RNA_ligase2		2'-5' RNA ligase superfamily	Bateman A	agb	Jackhmmer:D3Q0T5	Family	This family contains proteins related to Pfam:PF02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.15	0.71	-4.50	139	2076	2012-10-03 21:31:48	2010-11-24 11:46:27	1	31	1509	1	702	2552	184	152.70	17	68.99	CHANGED	sssshttt..lppl+.................thhstt...htths......sHlTLhhshhssp...........................spltptlpphht....................................................phps...Fp.lpl..sshstF.........tst.slalps.........................pstppltpL+pplhps......h.th...h..tt.............................tsapPHlT.....lupthsstsh...................................ptlhptl.......................tth.shp....hpls..plsLhphpsss	...........................................................................h..............h.........htt........HlT.L..th.h..t.c.h.s.pt..........................spltp.t.l.pph.ht....................................................ph.t...s........hp....l.pl....sth.us.Ft...........tss..sla.htl..........................................tssspLtpLpp.....plppt......htth........sh....................................psatPHlT.....lAp.t..h.s.spph...............................tphht.l........................t......hp......h....lp..phtLh......t...............................................................................	0	219	478	611
+13406	PF13564	DoxX_2		DoxX-like family	Bateman A	agb	Jackhmmer:D3Q9W4	Family	This family of uncharacterised proteins are related to DoxX Pfam:PF07681.	24.40	24.40	24.40	24.40	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.47	0.72	-4.05	115	1334	2012-10-02 13:32:46	2010-11-24 11:51:27	1	7	742	0	518	1577	778	103.00	19	78.74	CHANGED	llsslluhhhhh.uush.+l.h...ps......t..h.....h.....t.....shs.........p.h..G...a..P.tth.hhh.lGshclhGuluLl.....l.s..h.h....h..s...hls.hAAsGlshhhlGAhhsH..l..pts-s..t......t.....hshsl..shh.sl..shus	.............................hthlluhhh.hh.suhh.+l....h...ts................p..h.......h.....p.....ths.................p.h..G.....h....P...th..h....h..h..h..l..G..s....h..ElhuuluLlh.s....h...............hlshhA.uhhl.s.hh......h.l.u....A.h.h.s.H.....h.....tstc.....h............t...........hhhsh..hhh.hh....h.........................................	0	202	354	442
+13407	PF13565	HTH_32		Homeodomain-like domain	Coggill P	pcc	Jackhmmer:C2M820	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-10.26	0.72	-3.18	486	664	2012-10-04 14:01:12	2010-11-24 14:43:25	1	19	411	0	337	3654	468	74.30	20	27.49	CHANGED	Tl...t+aht+...a....pp...tG....ts...........t....tp....sups.....hp......sph..ptlhphht.....pp.................hospplsph.ltp....t............hS.tsolt.R.hL	................................................................oh.+Whp+..a..............pp....tG....tul.s...................h..t.tc....sG+s......pp......hssch..ptlhph.hp.....pps.....................phoscplspp.Ltp......th.h........ShsTlh.+hL........................................	0	104	210	313
+13408	PF13566	DUF4130		Domain of unknown function (DUF4130	Coggill P	pcc	Jackhmmer:C2M6X4	Domain	\N	27.00	27.00	27.70	28.50	24.80	24.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.07	0.71	-4.68	156	594	2010-11-24 15:37:12	2010-11-24 15:37:12	1	4	583	0	199	587	26	164.90	28	52.22	CHANGED	cpsp+hshlachlhhsh.phsp..plhpthucssVhp.ltphs+pVp+EtH+hcuFlRFpcl....ps.........shahAhhEPcaslLshlusHFscRassppWhIhD.c+thusha...cs..pph.phh....s.hs........p.....th...........ph...........s.ppEctappLW+sYacolsI.tRhN.+....hppppMPp+YWKtLsE	...................................t...p+hshlachlhps..h.p..tsp...plhpphuDs..sVhp......lpphsKpVp+EtH+hc.u.F.lRFpch...ts....................shahAhhEPcaslLshhusHFtcRassppWhIhD.p+thuh..ha..-s....pp.lphh....p.hs........s....t.........t...ph...........................s.ppEctappLW+sYapsltl.tRhN.+....hhpppMPp+YW+.LsE..................	0	59	132	167
+13409	PF13567	DUF4131		Domain of unknown function (DUF4131)	Coggill P	pcc	Jackhmmer:C2M1S0	Domain	This domain is frequently found to the N-terminus of the Competence domain, Pfam:PF03772.	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.92	0.71	-4.86	202	2454	2010-11-24 15:48:31	2010-11-24 15:48:31	1	9	2425	0	598	2213	149	162.40	14	22.34	CHANGED	lhGl....lhs.........hh.hhshhhhhlhhhhhhhhhh...hhh..........................................t.thth.........hhhhhhhhhhsshhhthtthphtt......pphsphht................tpthh.....lpG.hl.....tstPphp........spth.....pahlphp............htsttpt.hss+lhlth.ppptt...............hphG..-tlpl...puplptPpsstNP..utFDYppYL.tppsI..huphhspshphh	.......................................................................................................h....................h.....hhh...h.h.h..hhhhhhhh.hh.......................................................................................hh.....................hhhhhh.h.hh.h.hh.h.h..h...t..h..t..t..thtt.........pths.t.ht...........................h.........hps..hl................ss.h......p.hs........................................spth.........phhht.........................................tstpth.h.hcl.h..l.t..hptpt...................................hpsG...pphph...pu...c..lc.sputtN...........uuFD..hp..t..ah.ht.pslhthh.ht.....h....................................	0	189	382	494
+13410	PF13568	OMP_b-brl_2		Outer membrane protein beta-barrel domain	Coggill P	pcc	Jackhmmer:C2M356	Domain	This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound beta-barrel fold.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.24	0.71	-4.47	110	1717	2012-10-03 17:14:37	2010-11-24 16:11:55	1	14	223	0	538	2059	496	183.40	15	70.26	CHANGED	tAQ......p..................hp..hGhpsG..h..s.h.....sshph..................p...t...p........ph...sh.............ps.uhs..sGh..hs.chth...s..p....t....h..u....l..p..stltasppshph..ptp.....................t...........p...............ttphphphshlpl.Plh..h...paph...sp..........hphtlhsGsthuhhls.ppt.........p...tt...............t...............................t.ph...s..t....tph...pp..hshulthG..huhp....h..h...........p....hh...l...phcapa.GLsshhp	....................................................................................t..........................hphuhpsG..h..s..h.......ssht...........................................p...................p...sh..................ph....uhp....hGh...hs..ch.th.........s..p.....p......h...u....lp.....sslh..as.pp.u.h.ph.ptp.......................................p.......................................................ttphph.p..hs.al.p.l...Plh...h...paph....sp...............hphhltuG.s.hh.uhhls.sph.....................p.......hp.............t.........................................................tph..s...p......tph...p.p....hsh..u..l..s..hG....hGhp....h..t..................p.......hh.......l..phpaph..Ghss..................................................................................................	0	277	479	526
+13411	PF13569	DUF4132		Domain of unknown function (DUF4132)	Coggill P	pcc	Jackhmmer:C2M366	Domain	This domain might be involved in the biosynthesis of the molybdopterin cofactor in E.coli.	27.00	27.00	37.40	37.40	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.03	0.71	-4.75	83	961	2010-11-24 17:18:36	2010-11-24 17:18:36	1	16	526	0	149	754	8	181.60	41	17.24	CHANGED	G.KplKolPtsh+c-........tshpc....hpsh+K...plcphhstptpRLEpuhhss+pWssppa.pp.hhs.HPlhpplsccLlW...h......sss.......t.tshthh...cD..ss.........lsshcscth......p.Lsss.s.t....lpl..sHPlclst.tslssWpchht-hclhQPFcQltRc..lahlTss.Eps..tspspRau.Gthlps.t.ph.hu.hlpp+GWp	............................spRhKslP+.ptsDDp...pAs-AlschKtLKK...Dscplupp...plsRLEsAhpppRRWShtsFpthhVpHPlsRhlTpRLIW.GlY.....s.pp....................pLlssFRVA....p-..ss....................assAp.D-.h......s.LPss.s.......IGI..sHsLElos...pp......tutFuQlFADYElhPPF+QL...sR..p..o.ahLTt...........s..Eps..usp..LsRWtG+.psss.Gpl.hG..hpt+GW...................................	0	46	88	102
+13412	PF13570	PQQ_3	YWTD;	PQQ-like domain	Coggill P, Eberhardt R	pcc	Jackhmmer:C2M3Z1	Repeat	\N	22.00	18.00	22.00	18.00	21.90	17.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-8.19	0.72	-3.55	1244	1943	2012-10-05 17:30:43	2010-11-24 18:25:17	1	236	866	9	946	6594	2060	41.50	27	13.21	CHANGED	G.phh.....Wph...........ph...s..s...th.h...sss....................sh..s.....s...s....h.....lalsst...............suplh.u.l..-....sp..s	............................................Gphh..Wph.........................ps.......s......u.......ts.h.....usP........................sl...u.........s....G..............h.........Valsot............................sGplh.A.l..st..........................	0	381	735	860
+13413	PF13571	DUF4133		Domain of unknown function (DUF4133)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0094	Family	Based on Bacteroides thetaiotaomicron gene BT_0094, a putative uncharacterized protein as seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or vs when in culture [1][2].	25.20	25.20	25.30	26.00	25.00	25.10	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.08	0.72	-3.76	26	267	2010-11-24 18:36:44	2010-11-24 18:36:44	1	1	110	0	31	216	10	94.30	60	85.71	CHANGED	INKGIG+sVEFKGLKuQYLFlFAGGLLAlFllaVlLYMsGVsQalCluFGssouolLVWtTF+LNpKYGEHGLMKhhAt+pHPRYllsR+plh+Lh	..INKGIGRsVEFKG.LKA.QYLFlFAGGLLAlFlLh.VILY.MsG.lsQalCIuFGssuuolLVWtTFpLNt+YGpHGLMKhuAt+pHPRYllNR.+plh+Lh.......................	0	11	29	31
+13414	PF13572	DUF4134		Domain of unknown function (DUF4134)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_0095	Family	Based on Bacteroides thetaiotaomicron gene BT_0095, a putative uncharacterized protein As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), It appears to be upregulated in the presence of host or vs when in culture [1][2].	22.30	22.30	22.40	22.40	21.60	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.11	0.72	-3.88	27	454	2010-11-24 19:06:34	2010-11-24 19:06:34	1	3	132	0	47	312	15	94.60	48	88.66	CHANGED	pKthlhshhhlhshss..thApssuuuGhst...Ass.lsoYhsssspLhYAIuAVlullGulpVY.KhssGDpDlsKshhuhhGAClFLlssupll.uFF	......................p..thhh.hhhhhhsssu...sshAQG....sG.AGIsc......ATphVoSYFDPuTKLhYAIGAVVGLIGGlKVYsKaooGD.sDsoKoAuSWFGACIFLIVAATlL+SFF.......	0	16	42	47
+13415	PF13573	SprB	PbH1;	SprB repeat	Coggill P, Eberhardt R	pcc	Jackhmmer:C2M2H5	Repeat	This repeat occurs several times in SprB, a cell surface protein involved in gliding motility in the bacterium Flavobacterium johnsoniae [1]	26.00	20.00	26.00	20.00	25.80	19.90	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.70	0.72	-4.35	113	1000	2012-10-03 16:25:20	2010-11-25 11:10:41	1	88	62	0	782	1180	555	36.20	31	8.65	CHANGED	stssssloCtG....sssGolsl.ss.oGG....o..ssYoYp.Wssuss	......................ssso.C.u...........sss.G.s..l...s.l...s...s...o...G.G............o.....us....Y.oYs.assst...............	0	535	718	782
+13416	PF13574	Reprolysin_2		Metallo-peptidase family M12B Reprolysin-like	Coggill P	pcc	Jackhmmer:C2M7W3	Domain	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.58	0.71	-4.21	49	431	2012-10-03 04:41:15	2010-11-25 14:00:08	1	33	240	11	189	3218	220	181.20	21	27.86	CHANGED	hspshsthssshsplNtlYE.............c.-hu..lph.....sL.l..s.............s.spll.hhssso.....csass...............................sssshhspt.pshhssh.lGpp........sYDlGalh..ssh..ssuts...GluhlG..................slCs..ss.......pps..............oG........hs...........sPhGssh.........thch...lAHEhGHpFGusHohs...............s.ssp..t....o.u..ss..........EsuuGsoIM.u.Yu.....uh...sssp..............sl.s.p	...................................................................................................................................p....................................................................................................................................................................................................................ht..........tt.t.....................sh.s...h.....s.hlh..............tsh......ss.....u....sh..............Gl.Aalu..........................................ulCp..ps........pth....................................s.G............hs............pshssth.................uh.tT...huHEl..G...........HshGusHsss......................................................s..p.sp....s.....s..s..ts...................ps.tp.G....s.h.IM..s..ht..........sp....s.s..p.........F..S.s..o.ht.h......t..............................................................................	0	79	103	149
+13417	PF13575	DUF4135		Domain of unknown function (DUF4135)	Bateman A	agb	Jackhmmer:D3Q4V7	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 380 amino acids in length. The family is found in association with Pfam:PF05147. This domain may be involved in synthesis of a lantibiotic compound.	27.00	27.00	27.50	37.00	26.20	25.70	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.23	0.70	-5.46	79	396	2010-11-26 09:48:42	2010-11-26 09:48:42	1	9	292	0	97	356	22	354.20	24	39.27	CHANGED	YPVLsRhlspphpp.ahptht-lhp+lt.pD...................hppltpp....hhtsp.......sp..lsslph..u.h.uDsHssG+sVhhl..pFs....sG..h+lVYKPRs.Lpl-ttap..........phhpalspp....s..t....h..h.hh.chls.ct.....YGWtEalptpsCp................spp-lpcaYpRhGhlLulhalLsuoDhHaENlIA.......t.hPlllDlETl..h........p..s.........................p.h.....t...s....s...s..h.s.tp.t..p.......................ulhpsG...ll..s.t............h.h.....h.....s..s....t.p..u....................h..sls.hh..s.s......s...ps..hp...h.......hp........t......h..s......h.t...pts..........scsh....lttt.ttph.......................t...ss..tsYh.......ppllpGFppsY.phl..hpp.+p..c.l...hp...hlhp...FpssplRhlhRsTphYuplLp....tuhHPc.....h....hps.cpphhh.phh.......htpp.tttplltsEhpsLhpsDIPhFtsps	................................................YPhLh+hlspthtphhphhhcllppltpD...................hstlppp.............h.htp.........sp..lsslph.s..h....GDsHstG+oVhhlpFs.......su....+llYKP+slthcpthp...................................................plhphlspp....s..t.....hp..lhh.......chls....pss..............YuatEalpttssp............................................stcclpcaYh+hGhLlulhallsuoDlHaENlIu......pGphPllIDhETlhp..s.............t..h.......s....s.s..t...stt..t.t.t..................lhpSVhpoGlLPh.......h...h....t...p...pp..u..............hDlSuh.ut....p....ts.....pp...sh.p..h.h.l..hs.t......oDph....ht.ht.phph...tt.................hpsp.l...phtpYh..pplhpGFpphaphh..hp.p..+p..c.h.....hp...hl.tt...htshpsRhlhRsTphYuplLph.thcPs...........hh...pst..hcccthhpplh..............ttp.pppt.llttEhppLhptDIPhFhsp.s.........................................................................................	0	31	58	86
+13418	PF13576	Pentapeptide_3		Pentapeptide repeats (9 copies)	Bateman A	agb	Jackhmmer:D3PTZ3	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.28	0.72	-4.07	230	524	2012-10-03 04:02:01	2010-11-26 10:13:22	1	41	195	8	233	1940	556	48.40	27	19.80	CHANGED	FspspF.pss...sFp....pspFpsss....p....Fsp.spF....s.pspFpsspFp..ts..ssFppsp	.....................................................................................................FptspF.pss.s.sFp..........pupFpsss....s.......Fpp.upF.....ts.sssFssupFp....ts..ssFtts.......................................................................	0	69	184	226
+13419	PF13577	SnoaL_4		SnoaL-like domain	Bateman A	agb	Jackhmmer:D3Q8I0	Domain	This family contains a large number of proteins that share the SnoaL fold.	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.66	0.71	-4.22	175	2151	2012-10-03 02:27:24	2010-11-26 11:07:17	1	22	700	23	793	3721	973	126.70	18	73.54	CHANGED	ppLpscpsIppLhscYstthD..........p...........t..ch........c....th.s.s.lF..sp..D..uthchs...sh..............s..........h.hpG.........t..s..........slhshhps..................h.h..s........shh...........hs...........tH..hhs.s.hl.p.l....c...........G........D..p..Apupsh.hh.......shh.hh.s.s...................s.s.......s.ht..hh..hs.......u.tYp..cchh+p.............su..t......W+lpcpp	...............................................................stttIpp.lhsc.Ysts.hD...............p.............p..ch........c....th.ss.lF...ss.....D..u.h.h.phss.........................t.............hhpG..................t.s.......................slhs.h.hpp.........................................h..h...s.....thh.........................hs...........................tH....hhs..s.h.h.l..p..l......s...................u............-....p..A..p.upsh...h..h...sh.h..hh.ss.................................t.t...........t..t..hh...ts..........utYp....-p...h.h+p.............ss.t......W+ltph................................................................................................	0	154	493	664
+13420	PF13578	Methyltransf_24		Methyltransferase domain	Bateman A	agb	Jackhmmer:D3Q0B1	Domain	This family appears to be a methyltransferase domain.	26.20	26.20	26.20	26.20	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.37	0.72	-3.21	204	1368	2012-10-10 17:06:42	2010-11-26 12:36:09	1	67	883	14	614	4985	3811	113.70	21	37.53	CHANGED	lElGshpGtSshhlsps...h........pp..s..sh...........................................pl..h..........ulDh.......t........................................p.......htt..hhp......................................p......................tthss.......h..........sphh.........tsss....................tp........s.ht........pht.........................s..s...l.D...........llalDG...sH...s...h..........p...s...sht-..h...pth...h..s..t.l.p.s.s..u.....lllhcDh	.........................................................................................................lElGs.hGh...Sshhhst.s...h....pp..ss...............................................pl..h..slDh......t.t.....................................................p......htt..hhp.............................p............................ts.h.s.s.....h...............lpl.h..........puss......................p........s.ls.....pht.......................................s..s.l..D.....................ll.a.l.DG......s.H...t.....h......................p.....sshts....h......phh........h....s.......p..l.p.s.G..u.....lllhcDh..................................................	0	222	417	536
+13421	PF13579	Glyco_trans_4_4		Glycosyl transferase 4-like domain	Bateman A	agb	Jackhmmer:D3Q529	Domain	\N	27.60	27.60	27.60	27.60	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.16	0.71	-4.09	231	11449	2012-10-03 16:42:30	2010-11-26 14:14:27	1	99	3251	7	4057	16665	3336	167.30	15	40.28	CHANGED	GGhtphs.tplup.sLs...p...t.G..h..c....Vp..l...l..s..............s.s....tss...........................t.............ht.......t..s.........s....s.t....l.h..........t.l......s......hs.........tt..................t............t.......t.............h.t.........h.h.......................h....t.l.................tp....h..................l..................t.....................ttpsD....ll.a....s.p..s...h..h......s...s....hhs....h...h.u..........t...t.......t..s.......hP...h........lh...sh...........................+...............................s........hh........ht............t............tsh.........tt...p......h..h......t.......h.h.....pc......hhhpp..As...t......llsso.ptht..pt..lt.p.h..u....h..sss.clhllssu	...............................................................................................................................................................................Ghthh.h..hpl.sp...tLt.....t..........t...G.....h.....c...........Vp...l...h.s.............................t......t.t...................................................................t.............................s............s.....h..p........lh.......................p..h................s.............h...........................tt.........................t..................h.t.........t...........................h.t...........h.h..............................................................................t....t..l....................................................tp....h.......................................l....................p...............................................................................................................................................ptpsD.......ll..a......s...p......s.....h..h....................s..s........h.su.......h.....h.s........................t........t................................h...s.................................hP...h........V...h...sh................................................................................................H........................................................................................s.........hh...............hp........tt...................sh......................h.t...p................h...h...........t..................hh.........pc.....................t.h.h..pp.........s..c.....t........lls..sS..pt.h.......t........pp...hh..p..h......s.....h.......t....t.p.h.hl....................................................................................................................................................................................................	0	1455	2852	3553
+13422	PF13580	SIS_2		SIS domain	Bateman A	agb	Jackhmmer:D3Q8F5	Domain	SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.44	0.71	-4.46	65	4732	2012-10-02 15:05:26	2010-11-26 15:23:47	1	23	2778	42	921	4439	1821	135.90	30	60.55	CHANGED	pYhsph.ppllppl..pp........ptssIppAuchlspul..pssuhlalaGs.GHSthhApEhhhRsG....Gl.sshpslhh.slhLps...s..s.....t.tustlE+h..puhucp.lhpt..ht....l..pssDllllh.SsSGpN......sssl-hAhtA...+cpGhplIAlTo	..................................................................................t......................p.t.................ttI...p.pAuphlspuh..psG.G+llhsGN.G.s....S....u....ss.A.....chAsEhs..........sp...a.p.p....p..R....s.l.s.u...l....u....lss........s.s.............hloslus-hthc............p...l...a...u+....p....l...puh...................u...ptG.DVL.lu.I.SoSGsS.........ssllpAlctA...+pp..GhpsluLTG...............................	0	327	600	773
+13423	PF13581	HATPase_c_2		Histidine kinase-like ATPase domain	Bateman A	agb	Jackhmmer:D3Q5R6	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.69	0.71	-4.34	142	5237	2012-10-11 19:05:54	2010-11-26 17:53:18	1	183	1833	0	1838	7481	882	122.50	20	41.79	CHANGED	hsuphp.pltt.lpphlpph.h..tt.tslstptht........clpLAlsEAhsNslpHuhtpts.t...............t.l.................plp....................hthpspt....lpl..p........lpD.pGts.hsst.th..s.....................................sstttuGhGlhllpplhDpl..ph.............sss...Gsplphph	.......................................................................................................................................t..hth..s..Rthh.tth..h......tp......hs......h.....s........p...t..hp.................................s.l..p.l....s....l.....oE.hs........o....NAlpH.u.....h..t....t.....................................t.l..............................................plp.......................................h.t.h.p.s.sp........lpl...p.......................VpD...p.....Gss....hsht...ph...t...................................................................................sttppsGh.GLh..l.lp.p.l.s..-.....ph.....ph...............tst....Gpplhh....................................................................	0	613	1434	1724
+13424	PF13582	Reprolysin_3		Metallo-peptidase family M12B Reprolysin-like	Coggill P	pcc	manual	Domain	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.01	0.71	-3.60	94	288	2012-10-03 04:41:15	2010-11-29 11:26:57	1	38	237	4	116	3927	262	129.40	19	22.22	CHANGED	huthssslspsNtlac..p-hu....lphpLl....slhh......hsss.......s.s.....shss..sss..................tthls.pt...tsh.hss........t.htpsshDl.uplhss......................usuGlAhl..........ushsssspp..............t.uhss.ss..s.st.h.h................shhuHElGHphGusHo	...................................................................................................................................h...h.t.hshss.h..hp......p.s................lphpls.............th.h..............h.pht.................s...t........shhp..pst..............................................tp.hls..sh....ssh...pth......................t....p.p.ss....s...D.h.sh.h.hpthsh...................................ptssGl....Aal........................uuh.shspts.....................................t.shsh...sp......hst...sss......................................psht..HEl.GHs..hGhpH..............................	0	54	83	105
+13425	PF13583	Reprolysin_4		Metallo-peptidase family M12B Reprolysin-like	Coggill P	pcc	Jackhmmer:C2M7W0	Domain	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.35	0.70	-11.65	0.70	-4.80	9	268	2012-10-03 04:41:15	2010-11-29 11:39:56	1	39	198	0	78	3727	359	164.50	15	27.17	CHANGED	sh+shclulssDhoahpha....ushstlpphhhsslsthNclY.s..................pslGhplpLh....sspph.hTss.pss..as........s.s.spps..spthsshsshhGppshDhuhlhp.h....pss.sGLA.aluphs..........p.st.pu.ushuss.............................tp....pa..pl..hAHElGHhhGAsHshs............ussss.osts......-sssGs...oIMu.Y...sssspt..sh...FSssoIphI.th..hp.ushs	..........................................................................................................................................................................h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s....h..h.................................................................................p.....sh......p..s....hs......HElG.....Hs..LGhsH.s..hs.......................su.s.s.s....spsh.....................pps..p...t.h............olMu..Y.........hp..t.s.......................................th.....................................................................................	0	24	45	68
+13426	PF13584	BatD		Oxygen tolerance	Coggill P	pcc	Jackhmmer:C2M5J5	Family	This family of proteins carries up to three membrane spanning regions and is involved in tolerance to oxygen in in Bacteroides spp.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	485	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.74	0.70	-12.53	0.70	-5.90	64	896	2010-11-29 12:52:47	2010-11-29 12:52:47	1	20	707	0	273	880	568	397.70	18	74.48	CHANGED	hlh.h..sh..hs.....hAp.....sphpAp.s..s+stlu.sEplplshph.s..p...-s...c..s...........Fps...ssh....ps.Fc.V..hGP..spSp....sp..ph..lNGcso....psh..oaoYhLhsp+pGshoIssApl.hsGpphpopslplpVss.ssppspts..................................tthsspslalpspluKsssYhpEslhlsYKlYhpsslp..hs...hc.PchpsFhsppl...sp..ptphp..ptphsG+sYpslhhcphllaPQpoGcLpIsshshsssl...th..............spt..............p.s.....hF.G.t..p.hp......php+plpusshsIpV+PLPp..h+PpsFsGuVGpFshpssh.....s..p..splcsG-slohplslsGpGNlKhhphP..clp..hP...ssh-hY-schpppsphsssG.hpGshshpasllPpptGpasIPslpFsYFDspsppYcTlsopshplsVtpGs.......ss...sss....ss.......sspppht..spshphlc..p..sshht.h......p.p..phFa..soh.haahlhllshlh.hhl.hh.lhh+c.pttp..ps..clsth..+t+cA..s+lA.p+t...LppApchh..spp.pt	................................................................................hh..........h..ht......ph.sp.h..sp...tl..h...s-.hplph...s....t....ps....p...t............hph...sth.......ts.h....l...hts...p.sp....ph........ph....h..N...G.php..........ph..phthhl.hs...pp.G.htIPshpl.....G..hto.psltlpVht.tttt.........................................................................ttt.h.lps.p...l..s.......p.p.p..h.Y..tpthhhphclhht...........p.........ht.....................t.....................t........hp.sph.....p.s..h..h.hpph............sp...ttphp.................p..h....sG...tpa...pshp...pp..ahlhP..pp.sG...p..hp.....lsshthpstl.......................................................................u......................h..hphps..tshslp.V.p.sh......Pt.....ps..t...a....su....t.ph.p.lst.ph..................s....s....pp...h.psG-sloh..plpl...p...u....p...Gs.ht....h.p.hP....plt......hs......pshp.hY..s.tps..php.....t...s.t...t...t......h.....t..up.hs.phsllPppsGphpl.P.s.l.ph.saasspspphcph..phsshsl...pVtts................t.................................................................................................................................h.h.h.h.hh..h.hh....h..hh.hh.hh...............................................................s........................................................................................................	0	92	174	227
+13427	PF13585	CHU_C		C-terminal domain of CHU protein family	Coggill P	pcc	Jackhmmer:C2M7W3	Domain	The function of this C-terminal domain is not known; there are several conserved tryptophan and asparagine residues.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.25	0.72	-4.10	160	1085	2012-10-03 16:25:20	2010-11-29 13:23:00	1	223	183	3	619	1204	1201	88.80	27	6.67	CHANGED	lhls.N.shoPN.GDGh.NDhaplp.s....l.......ss.splpIaNRaGshVapsp..sYp....ssW.cGp.p.........ptLPsGTYaYllph........sst....ppt..hpGalhl	.......................h..lPs.sFoP.N..GDG..h..N.D.haplp.s..............h..p..ph......ss..hplpIa.....sRaGph.....l.......apss....shs.....................ssW.DGphps..................p.lPsG..sY.aYhlph.......tsst........t.......hpG.h........................	0	364	565	618
+13428	PF13586	DDE_Tnp_1_2		Transposase DDE domain	Coggill P	pcc	Jackhmmer:C2M1K3	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.48	0.72	-3.80	38	2848	2012-10-03 01:22:09	2010-11-29 14:04:42	1	17	787	0	763	3964	388	82.10	27	46.05	CHANGED	lpsD+hYcsccsRphhcc+..GI..+lusssls+ssp............hp.tttstttR.slEtpFuhhK+t.hpLsphhs+Lspottsh..lslshhlhsLc	..........................................................hsD+uY.ps.p.t...R.phhtpp...uh.......phs.lstp..tpptp............................h...s..hph.h.+p....R.p.h.lEphFuplK.p.a....R+..l.......u.....p..Ra.-Khspsahuh..ltlAshhlhh.................................	0	202	519	633
+13429	PF13587	DJ-1_PfpI_N		N-terminal domain of DJ-1_PfpI family	Coggill P	pcc	Jackhmmer:C2M3D1	Domain	This domain is found at the N-terminus of proteins from the DJ-1_PfpI family, Pfam:PF01965. The exact function is not known.	21.50	21.50	21.60	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.60	0.72	-4.42	59	1421	2010-11-29 14:19:25	2010-11-29 14:19:25	1	12	1169	10	438	1155	114	37.70	42	16.10	CHANGED	t+lLhVLTSHDpLGsTGc....pTGFWlEEhAsPYYsFpDAG	....................h+lLhVl..TS..t.s..p...h....s...s...suc....tTGhWLpEhstPYhshpcuG.........	0	117	250	366
+13430	PF13588	HSDR_N_2		Type I restriction enzyme R protein N terminus (HSDR_N)	Coggill P	pcc	Jackhmmer:C2M5G6	Domain	This family consists of a number of N terminal regions found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA [1]. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.46	0.71	-4.27	81	1412	2012-10-11 20:44:47	2010-11-29 15:02:48	1	34	1136	1	328	1237	289	110.80	21	20.20	CHANGED	PEEhVRQchlp.hLlpchsYPt.shltlEhtlp..h.s....s.pp.....cR...s.....DlVl...aspc..............tp...shlllEsKssplpl..sp..ps..h-QltsY.st.s..h...pupahlloNGhpphhhp..hs..h...ps...p.......p..aphl..scIP	................................................hl...hh.p.p.hs...Y...s........t..........p...l...h.s..Eh....phs...hs................p.pp..................c+.....s.....Dhll.hpps.......................p...PhhlIEs.......K..s..sphpl.......sp..............s...h.pQhhpY.hp.h.......h.....s........spash...loNGptahhhp........t......................................................................	0	106	235	300
+13431	PF13589	HATPase_c_3		Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	Coggill P	pcc	Jackhmmer:C2M6V6	Domain	This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.92	0.71	-4.51	55	9547	2012-10-11 19:05:54	2010-11-29 15:33:13	1	80	4481	84	3019	14695	4507	137.90	25	20.93	CHANGED	ho...psAlsELlcNulD.......As....Aps..................lplhls.......pp.........................tsltltDsGtGMshp..-...hh.p...sh.....p.hup...ss.p..p...t.......p.......p.....pps............hGc.hGl.G.KhAuhphupplplho..+...pp...up.ps....s..hp.......l...shphhpppp..s...h.l...ths..pth...............p.hpp..pppGT	..................................................t.hl+E.L.....l....pNu..hD..................As......s.p..h..............................................................................l.cl.p.lc............ps.......................................th....................pp..l..pl.p..DNG..........h.Gh.s....c-........-...........lh.t.....hh..........p...hsp...........o.u....p....p.........p..h..........p.................-.........hpt.....................................................IGp...aG.....h.....G...........h....h....u.....u.....h.....h.....s......s.......s......+.....l.....s...l....p.o..+......ps......sp..pt.......s..ht...............h...........................................................tstttthttttt........................................................................................................................................	0	999	1810	2464
+13432	PF13590	DUF4136		Domain of unknown function (DUF4136)	Coggill P	pcc	Jackhmmer:C2M2E4	Domain	This domain is found in bacterial lipoproteins. The function is not known.	27.00	27.00	27.10	27.20	26.50	26.90	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.91	0.71	-4.15	166	841	2010-11-29 15:34:22	2010-11-29 15:34:22	1	5	488	0	314	779	367	162.60	18	79.98	CHANGED	o..........h......p..lp...sDa....-pss......sF.s.....s...h+Tasahps..........tss....th...s.....sLpp..pRlppulpspLpt+.Gapt......u...p....s.s.Dhhlshthtscp.p........tss............h.s.s.......h............Gh......u...h.........G........au.....s..h..h............G.................s.s...hs..h............spp...h..pp....uo..Lhl-llD........sps..s.........c.........l.lWcGsupstlps...p.s...s....tppt...lsp...hVpplhspaPPp	...............................................ss......phs.th......sa.s.....sh+Tasahps..................st...th...s...sl...pt...p..p.lpsslsppLsp.+.Gap.......s.....sp....su.Dl.....hVphththppp......psh..........................hs.s.....h.............sh.....u...h.........................G................au....s..h..h.................s.................................hs.hsh..............stp....h....pp..ss....Lh..lcl..hD.......sps...s..............p.........h.lWpusupsthss..ps...s.......pppt...htp...hVpphhspaP........................................................................	0	81	179	254
+13433	PF13591	MerR_2		MerR HTH family regulatory protein	Coggill P	pcc	Jackhmmer:C2M362	Domain	\N	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.43	0.72	-4.38	56	920	2012-10-04 14:01:12	2010-11-29 15:57:16	1	2	905	0	189	833	159	83.90	38	81.93	CHANGED	lslsEhCppsslptshlhELl-hGl.lcs.ptt.s...p.....phh.hsspplt.plc+hhRLppDLslshtGlslllcLL-cl-pLppElppL+p	.....................hTlsEaCh+.s.G.loc-pLsElVslGllEP..cp..p....s..........sWh.Fcsc.....sshhVpRAhRL+c-LuLshsGIAlsLsLl--lscL+pEsRhLp.............	0	60	124	167
+13434	PF13592	HTH_33		Winged helix-turn helix	Coggill P	pcc	Jackhmmer:C2M2H6	Domain	This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.39	0.72	-4.43	87	787	2012-10-04 14:01:12	2010-11-29 16:08:47	1	15	372	0	214	1136	242	57.50	29	30.89	CHANGED	ssthWostpltphlpppaslpa.ohsuhs+lL++hGaSap+Pphh.shctDtctpptFtcph	...............................hppchshsY..ohsuhhpLL+.RtGa.p.hpP+sp.PtK..tD..s.pp..t.........................	0	28	108	155
+13435	PF13593	DUF4137		SBF-like CPA transporter family (DUF4137)	Coggill P	pcc	Jackhmmer:C2M6P1	Domain	These family members are membrane transporter proteins of the CPA and AT superfamily.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.84	0.70	-5.33	59	1645	2012-10-02 17:06:44	2010-11-29 16:51:02	1	8	1426	0	476	3347	1338	293.20	43	89.90	CHANGED	chFhlhLlsslhLAthhPs..h........Gpssshhp.t.hssshu.lullFhlpGhpLupptlhsGhtpWRLHlhlhhhoFllhPllsh.ulshhht..s..h...ls................................st.....lhhGhlaLssLPoTVpSuluhTohAtGNlsuAlssAuhSsllGlFlTPlLl.tlh.h...........s.ss...............ssshs.........htpsltplsLplllPhllGQllp...sh..h.s...p.......................aspp..p.cp.h..........lphl....DpssILLlVYsuFSsAhspGla..pplsh..hsllslhslshhLhhlllshs....hhhuRhL.t.............................as+............................pDpIslhFCGS.pKSLA.GlPh..usllFs.sts......tlGhllLPLhlaHthQLhlsuhLApphs+	...................................................................................D.FhlsLlssVll...Aoh.h.Ps...p............G.s.h...s...s.hh...........................h...o...s.hA...I........u..LL.F....F.h...a...G....A......+..L..S......p.....c..tlls..G..h.t.H...W.R.L...H.L..hV..hs.sT.....Fll...FP..ll..G.l.........h.....h.....t.....h.....h.....h.....s.....s..........ls...............................................s.........LYhGhLaLChL..PuT..VQ.SuI.AFTShAtG.N.VA..A..............AlsuASsSsLLGlF.loPLLV....uLlh...............s.sp..........................Gus.s.s..ht.p.....ltp.Ih...lQ.L..........L...lPFl...lGpL......R.....sa......l..u.......s..............................a..l..pR....p....+p.h........lshs.....D.p.....s.....S.....I.....L.....L.V...V.Ys..A.....F.....S...-..u.h.....s.p..G.lW...pp.luh.............ssL.l.h...l.l..ll.....s.h.lL.L.s.l.l.l..s..ls.......hh.hu.+.h..L...G...............................................................F.s..+............sD..c.I.s.I.....lF..CGS..KK.S.L......As....G..lPM..As..l.....LFs..s............slG.h.hV.LPL..MlF.H.QlQ....LhlCuhLApRat...............................................................................................................................................	0	127	265	386
+13436	PF13594	Amidohydro_5		Amidohydrolase	Coggill P	pcc	Jackhmmer:C2M675	Domain	This family of enzymes are a part of a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].	21.50	21.50	21.50	21.50	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.77	0.72	-4.15	1248	3712	2012-10-03 00:45:34	2010-11-29 16:53:58	1	83	2104	48	1323	23661	7737	75.40	25	16.55	CHANGED	lhlcss.+I........st..l...................t......tt.....t................l.D.....u.p.G..p.h.lhPGhID..sH.....sHh......................................hhtsh..tphttt......h.....................................sGs...............................T...T..............l	.....................................................lhlpsG..+I....................hs.l......................stt..hsh...............ss.sp.........................ll..D..............s...s..G...p...h..l..hPGhID..hH.............sH.h................................................................h.ts.h..................h.................................................ttGl.....T.o......................................................................................................................................	0	575	1004	1193
+13437	PF13595	DUF4138		Domain of unknown function (DUF4138)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4780	Family	Based on Bacteroides thetaiotaomicron gene BT_4780, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	25.50	25.50	25.60	25.80	23.60	25.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.40	0.70	-5.42	30	514	2010-11-29 22:10:22	2010-11-29 22:10:22	1	2	140	0	63	427	8	231.40	40	82.80	CHANGED	plpVshsKTsHllFPpsI+YVDlGSspIlusKApss-NllRlKA...................sspsF.s-TNhoVITtDGphY..sFslhYsspPsthshph.....................phtssstpshhpphss.sssthpphhhslapps.+cl+plss+paG.....lphhLpuIYspsDhhah+hslcNpSNlsYDIDhlRFKlsDKKhsK+TssQphtlpPlhshNthp..lpsKpshRsVaslsKhTlPD-KlLplElhEKs.GGRphslpIcNsDllcAcsl	.............................................................................s.lpVoasKTsHlIFPus.lRY.V.DlGSs.p.l.lAsKA-ssENllRlKA...................sscsF.sETNhSVI.TpDGsaY..sFNlpYss-PthLsh-h.p......................................................................................sphspsttplY...hp-lss.pS.....shh....h....ph.h..hpsI..a.pps........pRpl++lus+paG.....hphhLculYscsshlYh+hplcNpoNlsa-lDalpa.K.l.sDKKhsK+TAh...QE.hl.Plcs.hs.st..lsu+ps.R.sVasltKFTlP-DKhLhlEl.E+s.GGRp.ohhl-scDllpAc.h..................................	0	18	54	63
+13438	PF13596	PAS_10		PAS domain	Coggill P	pcc	Jackhmmer:C2M6E2 	Domain	\N	22.10	22.10	22.10	22.10	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.14	0.72	-3.77	87	1751	2012-10-04 01:10:46	2010-11-30 10:56:59	1	160	1165	5	368	2524	174	107.80	26	18.13	CHANGED	lsslLsohsl.tlsFlDcs.plphass....s...t....p....plhp.hhssslGRslssh....p...sp.....pt..hstl....cp.ll...pplcsspp..s.p.hchhh....s....p..s....s+h.hhh.phhsh+spsuphtGll.shhDlp	..........................hshlLpshPh..-lTa.lDcssphp..a.ass......s.....t....p.....hl..ap...R...s...s.s..p..l..G.+.....s..l.p..p...s........H.........Ps.......tp...hcp...V.........cp..ll.......p.s...l..+.sGpp.......c..h...h..chhh........s.......t.s......Gp..h...h..h..h..p..Y..t...A..h.+..s.p.s...G..p.atGllEhh.Dlp.......................................	0	125	250	306
+13439	PF13597	NRDD		Anaerobic ribonucleoside-triphosphate reductase	Coggill P	pcc	Jackhmmer:C2M7Y9	Family	\N	25.00	25.00	25.80	25.40	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	546	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.94	0.70	-6.43	45	3413	2012-10-01 23:28:04	2010-11-30 14:10:29	1	23	2857	5	604	2408	158	537.40	35	83.84	CHANGED	ptchclspsu.Nhs.huht.....tlsp.....hltphahpp...l.s.s.E.hs.cAH.ppG-laIHDL..sh..h...ssYCsuaoLpplLpcGhsslsG.....pS+PP+HhsoAhuphVNFlhshQspaAGAQAhssF-TYhAPFlRtDt.hsYp..............................-lcQtlQchlaNLNhPsR.hGhQoPFTNloh......sp.s.sh.....cs......lhG.sth...........................h.sttht.....s.hp.Ehchlp+Aah-lhhpGDupGpsFTFPIsThslppc...............ppssspt..lachsAKhuh..htsah.............sph.........-Pss......stuMCCRLpl-lp-htp...us..................................uLh...uus.tTGSIuVlTlNhsRLuhpucs.......ccc.t.h.tcL.......pc.h.p.l.s.......t........Rp.hlpchhp.....pGlaP.....a.hcph......Lhs..............L.cspFsTIGlsGhsEss.t.ph..stp..slp.......s.cuc.......phshclLcal+pphpchpccTGhhaNlEtTPAEusuh+hA+tD+c............c..s......lh..........psts...hh....sshats.ssphslshh-chh....hc.pc.lpshhoGGollHlaL.GE.p.h.sscuhtp.Ll+phh.p.hclsYholTssholCsspGalssc.ptpCPpCGpct.............sEhaoRlhGYh+.PVpu.......aNtGK+p.EatcRphap	...........................................................................................................................hh..s.NsNcsu.p.h.h.....sp.tc..........hhus.......hssc.hhhpp.....hLP....pc..ls.pAHpcGDIHhHDL...Da...h....hhsCshlshcshLppGFphGsu........plcsPKSIpoAsu.hspIluplsup.aGGpohsphDphLAPas...ptsh..pchcph.t............................................................................pths.tpsp+-hhpAhQul.Ypl....NThho.usGQTPFsolsa........GlsT.sh..............................................................................+.h.Ip.culLpsp...h...tG...l...u.p...t.+....T.s.lFP.pll..F..slccGh.Nhp..........................s.s.s..NYD...lhpLAhcsusKRhaPsl...................................................-h...........sssh........hs.sMGCRohLts....p.tp.....sp..................................tl..........tpGRs....NLGVlolNLP...R.lA.lcupG................................-ts....t...F.hcl..........-+.h.t.l..s.......p.............................+t.h.h.pc.htc............stshP......h..hh..h......hhphhtt.p...........t.s...hh..+p..u..p..h..o..l..GaIGlhEsh.p...ha..s..sp.....hhp.............st.pu.+.......thslpIlcch+ptsppap.........cc..h..Gh..tFSlhuTPuEuLssRFs+.hDpc......................c..FG.....ll...........slTD+s....YYTNSFHh.s...V.pp.p.sssa-Klc....hE.ts..a..h.ssGGaIpYsEh.sp..p.t..N.cAlcs.lhcauhp..+lsYh.uhNsslDpChp....C....G.........a...........p..........u.........t......c........s..........h........p..........CPp.......CGscc...........ttssVh+RssGYLs....sssp...................astG+pp.ElppRV+H.h.............................................................................................................	0	214	398	520
+13440	PF13598	DUF4139		Domain of unknown function (DUF4139)	Coggill P	pcc	Jackhmmer:C2M2S6	Family	This family is usually found at the C-terminus of proteins.	25.50	25.50	26.10	25.60	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.68	0.70	-5.12	85	674	2010-11-30 15:48:01	2010-11-30 15:48:01	1	18	418	0	391	713	87	256.30	16	54.27	CHANGED	lcloYhlss.A...u.WpPhY-l+ls..s.tp....sp.lplshtAtVpQpTG-DWs.sVpLsLSTupPsps.s..ssPpL.ts.Whlph...hpP......s.h......hst...hssh...........s...ttht..t..tt.h...tts.................s.......h..tt.t..h.....tptsht....s.tlppsshu...ssapls..t.holsusupst.......plslsphshsuc.hphhssPph.s.spAaLhAphsss......s.shslL.sGpss.lahDusaVGpsplsh.hss.......Gpchc.lsFGsDctlplcRphh.c.c..p.ss..p.G.hl.......sp.ppp.h.s.hphplpVcNtp....spshp.lplpDplPlSpscclcVph..................p...p....s...s...................ts..............s.hc............spc......GhlpWclsLssGp.spplphsaplcaPc	...................................................................................................................................................lpY.....h..t.s.....W.s.Ychtht......t...t......................t...htl.h.u.l.ptou.sWp.sstl.lsosps............t.t................s.....h.....s....hth.......................................................................................................................................................................................................................................................................................................t..t.t..t.t............htaph..t....hs.l...sstt..............hh.l..p.ph.....s..p..h...h........h.....h..........h.P.th.....p..............t....s.....h...h..s....p..hts...................t..thsl...G..st.lh...........h.....s.....s.....t......a....l....up.s.lt..hss.......spphp..ls..hG.-.tl..p....lp......hp.....p..t......p..tp..........ts.hh...................st...t..p.........hthphtlpNtt.......tpshp.l.l........-th...Ph...s...t....p..ttl.lt.............................................................................................................................................................................................................................................t.....t.h.athtl.stt....t..h.hth.hp.............................................................................................................................................	0	155	261	359
+13441	PF13599	Pentapeptide_4		Pentapeptide repeats (9 copies)	Coggill P	pcc	Jackhmmer:C2M218	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.03	0.72	-10.59	0.72	-4.17	86	6775	2012-10-03 04:02:01	2010-11-30 16:17:53	1	256	2008	57	1619	10345	2693	77.40	16	36.50	CHANGED	sphpsspFpssp.h........pp.ssFpss.....plcsssFsssp.h..........hpss..........Fpssp.....lpsspFpssp.h...pss....pFpssslp.sspF..p..s......p.lpsss.F	...................................................................................................tspF.p.ss.p.h................pt.s.sFp..ss...............plp.s.ssFp.psp.h.......................ppss...................................F.p.s.ss...............Lp.s..ssFp.s..ss...l............pps...................sF.p.s..sslp..ssph.p..t................................................................................	0	562	1041	1333
+13442	PF13600	DUF4140		N-terminal domain of unknown function (DUF4140)	Coggill P	pcc	Jackhmmer:C2M2S6	Family	This family is often found at the N-terminus of its member proteins, with DUF4139, Pfam:PF13598, at the C-terminus.	27.00	27.00	27.00	27.00	26.90	26.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.27	0.72	-3.58	88	387	2010-11-30 16:18:01	2010-11-30 16:18:01	1	13	299	0	212	388	20	104.20	21	17.80	CHANGED	sVTlassu...ApVsRp..us..l.s...l.ts..Gp..p..plhhpsL..Pssl.st..sSl..pl.s...stus.......ssl...tslp....hptp..h....hp.......ttsst.......plpplcpplcplppphstlpschs...sh...ptphphlp	.........tVTla.s.sp...AplsRp.....sp.l.s...L..ts....Gp......s..c.............lhlp.sL..s..ssl..ct..sSl..+V.p...upus........ssl.....hslp.........hptt...h..................ht..........ttt.st............................plpplcpplcplcppht.......tlpsphsshptphthh.t..............................................................................	0	74	133	193
+13443	PF13601	HTH_34		Winged helix DNA-binding domain	Coggill P	pcc	Jackhmmer:C2M278	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.44	0.72	-3.95	35	545	2012-10-04 14:01:12	2010-11-30 16:59:13	1	7	427	1	221	2120	231	79.50	32	70.80	CHANGED	lRLAlhShLhu...V-cA-Fshl+-phpuTsGNLSlplcpLcpAGYIplcKsFpG++PpThh+lTspGRpAFpcYlcuLcphl	..................................RLtlhuhLhs........scp.s.s.F...spL........+.c...hl..s....l.Tc.........GNLop+lptLccsGY.l.p..h...c..K.s....a..t....u.......+....+..............P.p.T.hhplTsp...G...+.......p...A....app....alpsLcph...............................	0	86	153	191
+13444	PF13602	ADH_zinc_N_2		Zinc-binding dehydrogenase	Coggill P	pcc	Jackhmmer:B3CU33	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.83	0.71	-3.24	420	4473	2012-10-10 17:06:42	2010-11-30 17:15:43	1	149	1864	6	1804	17425	4479	130.70	21	25.39	CHANGED	LGA-pll..Dhp.ptth....................h.t..p.hD....lV...........lDs.lG....spsh..pts........h..hh.......s..Gp.h..lth...............................hhthst.t..tthphhhhh.....................t.......ttp.L.....pplspLlcsGp....l+.shls.ps.aP..Lsc..sscAachl.csG+sp.GKlVl	...............................................................................................................................................................hGAptsl.......Dap...ptth............................th.h.pthD.....h.l.....................hDs.hG.....spth....pts.....................h..phl.......tss..Gp..l......lsls.s.................................................t...hth......t..t..t...h..s..h.ph.thhh.............................ht..........................tpp.L...............pp.l.s..p..L.....l....p.p.G..p..............l.....+......s........h..l...s...p.......s...a..........s........l...pp..........st...cA....a.p....hl....c....s......G....+.s...p...G.KlVl...............................................	0	552	1141	1527
+13445	PF13603	tRNA-synt_1_2		Leucyl-tRNA synthetase, Domain 2	Coggill P	pcc	Jackhmmer:B3CR81	Domain	This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.99	115	4853	2012-10-02 18:00:56	2010-12-01 14:32:33	1	35	4641	29	1125	8298	4984	183.30	43	22.35	CHANGED	+NWIG+ScGs-lpFplpst.p...p.......plp.VaTTRPD..TlaGVTalulAPEHPLspcl...scppsplpsFlccs+ppsshEpshtstE..KcGl.hTGhhAlpPls.Gcc......lPlWlANaVL.h-YGT.GAVMuVPAHDQRDa-FAcKYs..LPIp.VIp...sts.tp..p.p........ppAa..s-.cG...hLlNSu....pFsGls.sppAhptIschLc	................................................................................................RNWIG+ScGscls..Fs..l...p....sp....s......p...........................plp..VFTTRPD..TlaGsTah........slA..P..E.........H..s..L..s.p.pl...........................scp...p...s...t........l.......t...s.......a....l......c..c....s.p...p...p.....u.........s.....h.E....c...p......t......s..t..E.........K..p..G...V.....hTG.....h.....a.A....l...p.P....l...s....Gcc.............l.P....lWl.A...s.Y.VL..h..s........Y.GT........GAVMAVPAH.D.pRDa.EFA.p.K....a..s......L..s..I..h....VIp..............sss................h................................tptAa....Tp...cG......h.h..l...N...S....u............h.sGLs...hp..pAhptlhphL............................................................................................................	0	373	737	963
+13446	PF13604	AAA_30		AAA domain	Coggill P	pcc	Jackhmmer:B3CTP0	Domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.61	0.71	-11.30	0.71	-4.73	84	5200	2012-10-05 12:31:09	2010-12-01 15:00:29	1	89	3798	11	1137	10491	2582	192.00	29	21.89	CHANGED	pLsspQtpAlcplhsssphhsll.GhAGsGKToslpu.sppshcs.............p.G.hpVhGhA.oupAAcs.Lpcs............hG.......lpupTlushltthsp..................................hssps.....llllDEAGMVuocphtcllptspc.sGA.+llLVGDspQLtulpA.GusFctltcphs....sscLsplhRQc......ssht+.pAsptltpGcssp...uLshh.tppGplptsss	..........................................................................................t..t..Q.t....t....A....h...t....t.....s.....l.......t.......p.......p..................l.....h..........ll..oGG.PG..TG...............KT....T....s.......l...p..t.......l.......l..t..h.h..tp.............................................................................p...s...h....p...l...h..L....s.....A......P....T......G....+...A....A.....p....+.....ls...Es....................................................................h..G........................h.p.A...p.....T...l..H.....+....l...L.t....h....p..s.s...s...p..t.........p...............................................................................hh.s.t.s............lll..l...DE.....uS........M...........l..............D...........h..............h.............h.............h............s...........p.............L.........l...........p........s...........l.........s.......s.......................s.........s..........+.........l.lll...GDp.c.....Q.....L......s.......S........V.............t........s.......G..........s..............l.............h...............t...........-..........l...............h..............p..............t............t..............................h.l..p..p..hh.Rpt.....................h......s..h........................................sh..........................................................................................................................................................................	0	339	718	942
+13447	PF13605	DUF4141		Domain of unknown function (DUF4141)	Ellrott K, Bakolitsa C	kellrott	Bacteroides thetaiotaomicron: BT_4772	Family	Based on Bacteroides thetaiotaomicron gene BT_4772, a putative uncharacterized protein. As seen in gene expression experiments (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE2231), it appears to be upregulated in the presence of host or vs when in culture [1,2].	30.00	30.00	30.20	30.20	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.78	0.72	-4.77	24	314	2010-12-01 19:13:44	2010-12-01 19:13:44	1	1	144	0	39	229	13	53.60	45	25.74	CHANGED	+p+lhhlhhshh.hhsspA+AQWVVTDPuNLAQuIlNos+pIVpTSsTApNslpNF	...........hpplhhlhsssh..lhsspApAQWVVoDPuNLAQuIlNusKpIlpTSpTApNhlpsF..............	0	10	28	35
+13448	PF13606	Ank_3		Ankyrin repeat	Coggill P	pcc	Jackhmmer:B3CUD7	Repeat	Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.	20.00	17.20	20.00	17.20	19.90	17.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.28	0.74	-7.80	0.74	-3.13	248	446	2012-10-02 12:10:21	2010-12-02 11:06:47	1	179	202	0	271	70923	5071	30.10	27	4.47	CHANGED	p..s..p..os....L..p..h.A..st....p...s....p.....h...p.h..l.chLl.p....p....s..s...s...lst	.........................sp.Ts....L...H...h.A.......sp................p.........u.......p................h......-.l....l.chLl.p......p.......s..s....s..................................	0	129	176	221
+13449	PF13607	Succ_CoA_lig		Succinyl-CoA ligase like flavodoxin domain	Bateman A	agb	Jackhmmer:A3JZV1	Domain	This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.21	0.71	-4.57	213	2340	2012-10-02 00:59:22	2010-12-02 13:50:07	1	30	1654	2	873	4427	2578	135.40	36	17.93	CHANGED	sGs.lullSQSGu.luss.lhshutpp..s.lGhSphlShGN.ps.DlshsDhlc.ahsp...Ds.pTcsIhlYlEulpc..u.ccFhpsA+pss..tp.KPllllKuG+.....optGspAA..tSHT.uuluGsstla-Ash+psGllpVcshc-....lh-suph..l	...............GplAhlSQSuAluss..lLc.hApp+......s......l.........G...FShh.lol.Gs..ps..D....l...s..h..s..-..l..L-aL.uc....................Ds..cT..psIlLYlE.....s..l.p.....-.....u...R+....F.h.s...A.A.....R.pA.u....+....s..K...PllllK.uGR...........os.s.u.....t....c....h..s......sHs....u.u..h........A.....G....s....D.....s....s....a....-....A....s..h...p...cuGllRVpshcE....Lhssscsh............................................................................	0	284	570	741
+13450	PF13608	Potyvirid-P3		Protein P3 of Potyviral polyprotein	Coggill P	pcc	Jackhmmer:P04517	Family	This is the P3 protein section of the Potyviridae polyproteins. The function is not known except that the protein is essential to viral survival.	25.00	25.00	25.10	25.10	22.00	24.60	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.77	0.70	-12.53	0.70	-5.36	65	976	2010-12-02 15:02:58	2010-12-02 15:02:58	1	24	129	0	0	1226	0	381.00	35	16.23	CHANGED	shchLIKula+Pchhppllp--PYlllhullSPslLlshassuulEpAhphWlp+cpslutIhshLpsLAcKVShAcsLhpQhplIppsuspLhchlpss.pss.h.u.h....phuhph....Lphh..tpcscssppLhpsGFss.hp.pphhphhEK....pYhptLcppWp-LohhpKhphhhpsp+hptthpptLp.p..sts-hpst.hshSspthhspstpphpsshs.....pshppspphh....psht.pphhshslp.slpthhsDlhphlNlhlllSlLlslhpslpshlppt+ph+tp.ht.thcpccptpplttha.h.a....sphp.p....c.t...ss...ptpFh-a...lc.....phpPcLhphh..p.hh....tp..pp..VpaQu.KsssptpLE+IlAFhuLlhMlFDsERSDsVaKlLsKlKslhuohspc...............Vp..............a.Q.S..LD..-Its.hh--KphTIDF-lsssttss.sssh.-.sTFppWWspQLppNRslPHYRTpG	................h+hLl+ula+P+hhppll.p-PYlllhullSPulLhuhYpssthEhuhphWIpccpslAhlhslLptLAt+VohupsLhtQhplIppsutpLh-hhtss.p..h.u.h.....hu.hp.h....Lphh..hppppssppLhptGass.hp.pphhphhEK.....Yhp.LcptWp-LSahEKhuhhh.t.+hphthpc.lh.p..stsDltuh.hshSspshhtpshppl+sshp.....thtpchpshhpt.phttl.shhlt.ththhhsshhphlshlllhSlLlplsushpshlppp++hKt.htthctccp..tl.hhathh....tpht.s....ptPohpcFhpalp...thsPcLhphh..ps.h.....tp...psVhHQu.K.pssptpLEpllAFhALlhMhFDsERSDsVaKlLNKhKulhuohspp...............Vp...............a.Q.S..LD..-.l.s..h--+phhlDF-Lppst....p.....-..hpFtpWWspQlp.s..slPHYRopG.......	0	0	0	0
+13451	PF13609	Porin_4		Gram-negative porin	Bateman A	agb	Jackhmmer:A3K5H9	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.28	0.70	-4.91	115	4742	2012-10-03 17:14:37	2010-12-02 15:24:35	1	10	840	14	1423	6841	1393	323.20	20	89.64	CHANGED	As.s....sls....u....s....uus.A.tA.ps.....................sVslhGthc..hslt...................hhs.......s.tt....s..............tsts.....t.tssht....ss....s..cl...........shps..........ptphs...sGhs....h..tuth..pL-...................ss....t........s....................................................ss..s......sh..s..............scpu.....hlu..l.su..saGplphGc.......p..ts................sh..pphhs....th....s..h.t....hs.s.hssh....t................h..shs....ss..s.s...........................................................s......................sttsssl.....hhhs..ss......hu..G.h.shussYshsp.ss..ss...................................................st......sphh......slss.s.Y.s...h.u....shssu.su.....as..................psp.sss.......................phhshu.sp..hsh...us.h.............slsus..........as.......phpssssht..s.......................................scts.sht.....luss...a.sh.....s.s..h.s.lsssY........sphc.s..........s....................sssscspthslussYsL..up..pssl..aup..huh..h.csc...s.s	.....................................................................................................................................................................................................................................h..s.shs.....h..h....u..s.s...A...tA..po...................................................oVoLYGhl-..sulp.......................................ah.s................stts......s.................................................psht.......h...t.s.s.sh.......ss..........S.Rh..............Gl+G..........sE-.LG...sG............h..tAhF..pLE.....................ssh............s............................................................ss...s...shh....................sRpA......aVG...Lss..sa...G...p.ls......hGR................p..hs................................hh.....s.hhs......................s...ht......sh..s....hss.h......t..........................h.....h..hs.......ss.............................................................................................................................s.......................phsssl......tah.o....ss.........au.......G..h.phs.ut..Yu.hus.ss..st.....................................................................................................t..tspsa.............uh.uh.s.Ys......hu.......s.hslu...su.............Yt.............................p.pssss.........................................tp.ptht.h...u..us..Ysh...us.h..................pl..su.s....................................Yp...........ps.p.h.p.s.s.hs..s..............................................................................tchs.sht....l..us.p......Y...ph......s.s...h...s..l....t..u..u..Y......thscs...............ts............................................................................ssssp...h....pp.h........s...l..u....ss..Y.t..L..SK....+Tp..l..Yst..hsh...p....s................................................................................................................	0	153	515	976
+13452	PF13610	DDE_Tnp_IS240		DDE domain	Bateman A	agb	Jackhmmer:A3K4H6	Domain	This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.56	0.71	-4.21	25	3068	2012-10-03 01:22:09	2010-12-02 16:00:46	1	16	1006	0	405	6167	734	118.80	40	59.33	CHANGED	upsW+lDETYl+l+GcWpYLYRAVDpcGp.slDahLop+RDttAA+tFh++slcptt...tpPcsllTDphsuYstAlcclt...t..ch.................tplpphpsK.ahNNhlEpcHphlKp+h..pshpGF+ShcsApphluGh-shpslp+sph	..................................h..pW+h.DE.T..Y..l...K..l..p........G.+..W..t..Y..L....Y..R..Al..Ds............c.Gp..Tl.DhhLp.p.p.R.ss.p.u.A.h.tFl.p.+....l....l.pph..........stP..p...h..l.....s..T.....D......p.......u.s..u..h......t...t......A...h..t.p.lh....p...th....h......................................................................t.h..p..Hp....p.....K....Y...hNN...lIE.pDHthlK.t.h..h..........ht.a...p.....S...h..p..o.A....s.h.l.p.G.h.E.s.h.hslh+tp.t.............................................................................................	0	90	222	337
+13453	PF13611	Peptidase_S76		Serine peptidase of plant viral polyprotein, P1	Rawlings N, Coggill P	pcc	Jackhmmer:Q65730	Domain	This family is the P1 protein of the Potyviridae polyproteins that is a serine peptidase at the N-terminus. The catalytic triad in Swiss:Q65730, the ssRNA positive-strand Brome streak mosaic rymovirus, is His-311, Asp-322 and Ser-355.	27.00	27.00	27.00	27.00	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.79	0.71	-4.00	6	57	2012-10-02 13:45:52	2010-12-02 16:11:56	1	12	13	0	0	162	0	123.60	34	5.04	CHANGED	Esll-.clsssccpsIc............Kp..ALhKp+pp.+l..VAN...lsDLsppLopICsEpGIPIl.lDppKR+AI.Ph...........V+L+Hlht.pl...tpDDhat--RhFLEHhst.ppshRssc..+Is.p.VRPGWSGsVI	...........................................lh-.cl.hhc.hch+.....................p..A.h+ch+...p...ppl...lus....lsDLhppls-IChEcshPIphIsssK++.sl..sh...........V+L+Hsht...ch....hs...tpDDMh.s.-RtalpHhsh.ttshp.sc..KIppp.V+PGWSGsll....................	0	0	0	0
+13454	PF13612	DDE_Tnp_1_3		Transposase DDE domain	Coggill P	pcc	Jackhmmer:B3CSW4	Domain	Transposase proteins are necessary for efficient DNA transposition.  This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction [3].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-10.75	0.71	-4.48	38	1053	2012-10-03 01:22:09	2010-12-02 17:12:34	1	4	328	0	267	2914	378	123.10	32	58.29	CHANGED	hGcsTGIuFIDSTslsVCHNhRI.c.HKVFcGlApRGKoohGWFaGFKLHLllNcpGElluhplTsGNlDDRcPl..ptLscsLhGKLauDKGYISppLhcpLhpp.GlpLlTplR+NMKspL.hshhDKhhLRKRulIETlsDpLKNlsQIEHSRHRSl	.............................................................h.hlDSh.l.l...Cp.hR...t....t.+h.....h...p....s....h.....A.p.h....G..h......s..s..h.....t.......a.......a...a................G...aKlHh..l..h...s..p.p.G...l.h....s...a..h.l........T..u.sscD..hpsh..........h...h...........p.............t.....h............h.............s............h..........l.h........u..D.........cGY...l.u.........p.p...L...h..ppL...h...t........p......u....h............p...l........h........T......................h.......+.........p.........N......M.........c..........t..........t..............h...................p..................c....c.........h....h....h.t.p....Rth...IEoh..s.Lhp.hph.p.hh.........................................................................	0	82	137	182
+13455	PF13613	HTH_Tnp_4	DDE_4_2;	Helix-turn-helix of DDE superfamily endonuclease	Coggill P	pcc	Jackhmmer:B3CR78	Domain	This domain is the probable DNA-binding region of transposase enzymes, necessary for efficient DNA transposition. Most of the members derive from the IS superfamily IS5 and rather fewer from IS4.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.69	0.72	-8.09	0.72	-4.43	117	1593	2012-10-04 14:01:12	2010-12-02 17:48:36	1	20	366	0	326	1064	32	50.00	44	29.09	CHANGED	p+L.shp-plllsLhaLRpshohppLuhtFsl.upoTss+hlpphhshLttphst	.........+L.shED.LhhTLpYlR-Y+TY.cpIAscF.G.I.p....ESslhRtspaVEssLspsu..h..........	0	161	288	317
+13456	PF13614	AAA_31		AAA domain	Bateman A	agb	Jackhmmer:C4FZU1	Domain	This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.60	0.71	-4.29	61	7392	2012-10-05 12:31:09	2010-12-03 11:32:26	1	25	3411	29	2053	16785	5368	138.30	24	29.84	CHANGED	cllulhSshsphGposhAlsluphLuppt.t.........VLhlsh-thsu.tthh.ptttp.................sls-lLhhht....t.....plsshlh..ph....sshshlsshpssp-hptlstpchtpLlpplpp..tY-..hlllDlushhpthhs...lLphscplhlssppsshutpp	.....................................hlhlsSs.p.sG..G.Koo.lusNL.A....hsl...Aptut+.........................Vll..l..D.u..D.....h.....p....p....s......s..h.......s......p.......h....h...s...h.ssp.........................................................Gl..s....p....h.l....ts.t......................................................p..h.p..p.h.h........th.....................sh.h......l......h......s.........s........s......................s.........s.........s......s.........s.........p.............h......l..........t...........s...........p.........p..........h.............t.............p............l.........l......p..........hpp...............pa-............hlllD....s.s.s.........h..h........s.s....s....s.......h....l...h.p.....h...s...ss.h.lhVsp.t......pt..................................................................................................................................................	0	671	1329	1734
+13457	PF13615	Racemase_4		Putative alanine racemase	Coggill P	pcc	PF09739_manual	Domain	This is a family of eukaryotic proteins which are putatively alanine racemase.	22.40	22.40	23.00	25.70	21.80	20.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.26	0.72	-3.77	39	179	2012-10-03 05:58:16	2010-12-03 16:56:07	1	7	148	0	127	188	5	102.40	37	17.07	CHANGED	lsaL.sp.sLt.GDsLAAEalLLaLlSp......VhsR................ss.shs.lGphoLNL...sshstps....................hsppLtphlppllPtsthlslolpsLNs...hphs.P++Dhpss+LhoGlLQLu	.............h.taLop.sLh.GDpLAAEYLlLHLlSp......VasR................p-..shs.lG+hoLNl...oshspss.................................................................sasppLhpllppLlPtohhlshTl-shNp...hphh.P+......KDYpsN+....LhoGlLQLs..........	0	58	76	106
+13458	PF13616	Rotamase_3		PPIC-type PPIASE domain	Coggill P	pcc	Jackhmmer:B3CTU8	Domain	Rotamases increase the rate of protein folding by catalysing the interconversion of cis-proline and trans-proline.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.39	0.71	-10.55	0.71	-3.83	68	3691	2012-10-02 13:30:10	2010-12-03 17:11:49	1	35	2370	6	991	7167	3075	115.00	30	30.29	CHANGED	hplhKllsppp...................hsD.SlpspHIhls.................spsttcA.+ppADSIhsslp.sGu.cFssLA+caStD.t..ttpGG......-lsWhs.....tu......phstpFtsslhss.psucl.t.slcoshGhHIlp...Vh-++	......................................................................................................ttt..............................tp..phpspHILlp..s...................................................c......pp....A....cp.l....h....p....c......L..........c....s........G..........s......c.........Fu....pLA+p.h..S..p..D..s...u......s......t..p..p..G...G...................-L.G...a.hs............tu.................phs.s.t.F.c..c.A.shsL....c...............h.....G.....p....l......o....s.......P......V......+.....o....p.....a....G......aH..II+lp-h.......................................	0	308	613	823
+13459	PF13617	Lipoprotein_19		YnbE-like lipoprotein	Bateman A	agb	Jackhmmer:B8H670	Family	This family includes lipoproteins similar to E. coli YnbE Swiss:P64448. Protein in this family are typically 60 amino acids in length and contain an N-terminal lipid attachment site, which has been included in the alignment to increase sensitivity. The specific function of these proteins is unknown.	22.60	22.60	25.70	25.10	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.87	0.72	-4.34	77	733	2010-12-04 11:44:36	2010-12-04 11:44:36	1	2	727	0	121	293	18	58.00	58	90.54	CHANGED	hhhhhshhsshhlu.uCo.......Pplclp.sPc..cPIsINhNVKI-HEIclKVD+-l-sLlpspssL	..........hhlsuhhuohhLs..GCT.......PRIEVA.APc..EPITINMNVKIEHEIhIKsDKDVE-LLcoRSDL..............	0	26	57	89
+13460	PF13618	Gluconate_2-dh3		Gluconate 2-dehydrogenase subunit 3	Bateman A	agb	Jackhmmer:B8GVK2	Family	This family corresponds to subunit 3 of the Gluconate 2-dehydrogenase enzyme that catalyses the conversion of gluconate to 2-dehydro-D-gluconate [1] EC:1.1.99.3.	23.40	23.40	23.40	23.40	22.60	23.20	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.74	0.71	-4.00	170	695	2010-12-04 12:21:38	2010-12-04 12:21:38	1	6	483	0	300	712	280	143.80	22	62.23	CHANGED	sspch.phlssls-tll.....Pps.ch...PuAt.....t......................................ssls.tFl-phlss............................spp......................................p..phhptGlst....l-phspppa..sps.FssLssppp.stlLpthptsph.........................................t..........stF....F.phlpshslpGaas.s.h......atGsps.hht.a................hPG	................................................................tpchshlpuhscpll.....Pp-..c......sGAh.....p....................................ssVs..tFIDpplss..........................s....t................................p.phaptGlss....l-phupppa.....scs.FspLs.s.t.pp.-plLpshppsph.................................................t.th..sphFF.shlhp.shpGaas..sPh..............asGsps.hhu.a........hP.........................................................	0	78	182	257
+13461	PF13619	KTSC		KTSC domain	Bateman A	agb	Jackhmmer:B8GXL8	Domain	This short domain is named after Lysine tRNA synthetase C-terminal domain. It is found at the C-terminus of some Lysyl tRNA synthetases as well as a single domain in bacterial proteins. The domain is about 60 amino acids in length and contains a reasonably conserved YXY motif in the centre of the sequence. The function of this domain is unknown but it could be an RNA binding domain.	21.40	21.40	21.40	21.50	21.00	21.20	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-8.82	0.72	-4.33	89	426	2010-12-04 12:39:23	2010-12-04 12:39:23	1	7	377	\N	139	373	132	59.70	28	54.38	CHANGED	lsS..SslpuluY....DspsptLplpF.....psGs....h.YpYhsVPtplapshhs..As.......ShGpaasppI.+....sp.Ys	............S.otltulsY....DspsphLclpF.....psGs......h.YpYhsVPtplapshhp....us.......StGpaapphI+.....sp.a....................	0	31	81	109
+13462	PF13620	CarboxypepD_reg		Carboxypeptidase regulatory-like domain	Bateman A	agb	Jackhmmer:B8H1B8	Domain	\N	28.50	28.50	28.50	28.50	28.40	28.40	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.92	0.72	-3.92	622	6052	2012-10-02 19:08:27	2010-12-04 12:41:19	1	501	1121	14	3219	18992	4276	80.30	21	11.43	CHANGED	s..lpGpV...p.D.s...s.G..t...sl......ssAsVp...l...pt............t.....s...........t......s...ts......s...h.T..s.ss.Gpapls..tl...s.s.....G..s..Y..p..lps.....st.G..ap..stp.h.............p..ltl.p.s...s..p.....s..t.s...l...s...l...s......L...p	...............................................lpGpV.........h..-.s.....s..G.....p..........s.l.........s.sAs..Vp.........l......t....................t.......s......................................h.......s.....ts................s....tT......s.....s.s..Gpa..p...ht......t..l..........ss.......G.....s....Y...p..l.p.s...........s.t...s...G......at....stp.h...................................ltlt......s..t...............h..t.h.............................................................	0	1542	2401	2868
+13463	PF13621	Cupin_8		Cupin-like domain	Bateman A	agb	Jackhmmer:B8H2W4	Domain	This cupin like domain shares similarity to the JmjC domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.79	0.70	-4.88	90	2241	2012-10-10 13:59:34	2010-12-04 13:30:07	1	98	579	36	1539	2844	306	243.80	17	46.84	CHANGED	spph...pchlspspPlll+u..hs..p..c..WP...shpt..Wpp............hcYLtpt.hss.htVp.....................sthts.t.t.sth......................................................................h.tt....s..hp.hhs..h.p........ttphshpch..................................lsp.lpptt..........t...................................sh.Yl.................t.....sss...l..sp.ph.st..l.t.......................p.....c...........psls...h.hs...thh......s..t.............................tss.........................................................lWlG..................................stp..s...p...oshHaDh......h-....................NlhshlpGcKcFhLhPPpphs............pL........................Yh.s............................shp......................ts...s..........................................................................................................................................h.....Sh...............lD.h.p................................................psDh..p.........caP..phpps.........ps.hhspLpsGD............sLalPuhWaHcV.............................cu.......h...............ss....hslulNa.Waptt..st	.................................................................................................................................................................................................................................................................................................................................................................h.........h....tpPhll.ps..h.h....t.....t......hs.........s.hp.t..Wp.............................phh.ph...h.s.p.h...l..........................................................h.t...t.....................................................................................................................................................................t...t..................thph.sh....ppa.....................................................................................................................lph....h....pp....tt.....................t.............................................................hhhh.....................t......ppth........p...th.......s.t.l.h...................................................................................................t..c...............ths..........h..t....th.h.........s...pt......t..................................................................ths.................................................................................................................................................................................................ha.h..G.....................................................sts.....s...h...osh..Hh..D............h.p...............................s..h..h........s....l......p.........Gp..K...phhLa.s.P...p.p....t...t.....t.l.........................................a.t.........................................................s................................................................................................................................................................................................................................................................................................................................................................................................................h.s.......l.s..h.t..................................................p.sh....p.........pa.P.....th.tps.............ps..h.cs...hl..p.sG..-..................................hLal.....P..stW.aHt.V...........................................................................................................................psh..........................t......slulsh..a......h......................................................................................................................................................................................................................	0	639	928	1286
+13464	PF13622	4HBT_3		Thioesterase-like superfamily	Bateman A	agb	Jackhmmer:B8GZN3	Domain	This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily [1].	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.85	0.70	-4.64	200	2392	2012-10-02 20:54:35	2010-12-04 15:19:22	1	22	1107	8	1028	4235	1639	249.30	20	84.50	CHANGED	hsssWt............................sthsaGG.hss...ullhpAhppt...............tss.....................hthhplsssalt.ssssu.shpl.....pscslR.........sGRshshlpspl..hp.......sut.....................s..sspupsshhpsp.t..............................................sshP.sP........spp........h......................................h-h+hh......................................hsssss..hphWhRhp.ssh...........................................t.........lhhlsDsh..sshshthhs.........................................hss.slsh.....olp...............h.......................t....phP.t..sp...........Wlhhcs.....psphsssGh..uttpsplaD.................pp.G..hlupupQsshl	..............................................................................................................h..............................ttsaG..G..lhu............p.s....l....hs.Atcss..........................stt...........h.spSl.p.s.hF..lt..su..s.....s..s..P..l.hh.........pVcpl.R..............cG.+o..hsstp...Vps...h.Q.............pGc..........................................s..lhpspso.Ftt...tc.ps.................................................................t...sshP.................s.P-p....h...s..tt.....h.............h................................................................h-hR.hst...............................................sststts...h...thWhRsp..ssh.ss.........t.................................ph......t...........LshhuDhh.........sssh.h.hhtth........................................................................hhhs.....ol-h.....sha................................................h.ctP..hph..sc.........Wlhhpt.............pos.u.s.su..h..uhspuplas............................ps.G.pLlAsstQpuh................................................................................................................	0	253	600	877
+13465	PF13623	SurA_N_2		SurA N-terminal domain	Coggill P	pcc	Jackhmmer:B3CTU8	Domain	This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.84	0.71	-4.21	6	236	2012-10-02 13:36:56	2010-12-06 09:20:05	1	9	235	0	66	1450	838	139.80	32	20.93	CHANGED	LGKIRS..KGslLlhlIGLuLFAFlA.psh.RSCpus+sppRpQVGEVhGEKISlQDFQKhl-EYppsIK.hp.tp.s.....ppE..pQVKDtVWpphVsN+LlEt-AK+lGLTVT-pElQsVLptGsNPhLhQT........PFV.pQ..TGRFDssuLKpFl	......................................................................................LppIRs..K.us..l..L..l.l..l.I..G...lA..LF..AFlh....u.sh....hp.s.....t...s.........t....t...ps..p.p.....V.G.c.Vs..G-.p.Io....h....p-....a....p...p....h....V....-..p........h...s..t..h......+....hp..t.Gt.....ss......................hsp..p............s.......Q..l..+..cpV....WpphVpptll.pp-sc+LGlsV..octE.l.p.s.ll.....t........s..s.s..P...hl.hps..........Phh...ss.psGtFDtstLppal................................................	0	27	54	61
+13466	PF13624	SurA_N_3		SurA N-terminal domain	Coggill P	pcc	Jackhmmer:O66854	Domain	This domain is found at the N-terminus of the chaperone SurA. It is a helical domain of unknown function. The C-terminus of the SurA protein folds back and forms part of this domain also but is not included in the current alignment.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.88	0.71	-4.24	9	2783	2012-10-02 13:36:56	2010-12-06 10:42:40	1	22	2338	1	800	3368	1934	155.70	23	29.90	CHANGED	MhchIR+..p..s....c..hhtslhsllshhFhLh..uhtuh.pp.h.upp.ssVApVsGpsIphp-ap+.....chc....h......hpp.hp......sp..........tpch.....lppt.....lLcshIs+cLLhppAp+hsltVoDppVsctIpp.PtFQ..s.GhFstphYpphLtpsshostpaEp.l+cplhlp+ht	...............................................hpt........t...................hh.h..h..h...h.h..l..l.h.l.s.F..h...h.s............G...l..s.....uh.......h........h..............t.....s.......ss....s.......h....s...A....p....V.s...s...pc...I.op..s...c...acp......................t.hp............p......................p.p.p.hp.................p.p.h...........................t.t.pt....................l.+pp..................l.LspLIs.ct....L.L....t.p...h......A.........cc..h...s.l..s...l....S...........-......p....p...l......c.........p........t.........l.........h........p........h.........s........t.......F.......p......s.....s.......G.........p.F..s..p...p..p..a....p.t...h....L....p...p..................u..h..o.....s.....c......p.at......ptl....+pplhhpp..h..................................................................	0	290	539	681
+13467	PF13625	Helicase_C_3		Helicase conserved C-terminal domain	Coggill P	pcc	Jackhmmer:B0SDT2	Domain	This domain family is found in a wide variety of helicases and helicase-related proteins.	32.50	32.50	32.50	32.50	32.40	32.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.37	0.71	-4.38	93	1240	2010-12-06 10:42:54	2010-12-06 10:42:54	1	14	735	0	510	1049	240	129.40	30	19.02	CHANGED	sllVQuDhTlll.s.ups.s.sp.hs.c.tlushA-l.E.Ss.ttspsYRlTshSlhpAhsAGhsA-pllshLppaS...+hsVPQsLhhhlsDsspRaGpL+l.....tt.....s..u...hhlcssD.slLs.clhtstph.pslhhcc.l..uPssl	...........................lllQu.D.t.T.l.lL-s.s.p..t.sc.tA.c.tLsshAEh.c..ps..pplHsYRlTshSLasAhusGhss-pllshLtca...S.......+h.s.V.Pp..u......Lh.h.......hIs-..ssp.caG+l+l.....tp..................sthhlcssD.slLppl......Lpsptltshhht.p.ls.t.................................	0	192	352	454
+13469	PF13627	LPAM_2		Prokaryotic lipoprotein-attachment site	Coggill P	pcc	Jackhmmer:C6QHI9	Motif	In prokaryotes, membrane lipoproteins are synthesized with a precursor signal peptide, which is cleaved by a specific lipoprotein signal peptidase (signal peptidase II). The peptidase recognizes a conserved sequence and cuts upstream of a cysteine residue to which a glyceride-fatty acid lipid is attached [1].	27.00	27.00	27.00	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.07	0.72	-7.18	0.72	-4.14	142	1185	2010-12-06 13:22:07	2010-12-06 13:22:07	1	2	1178	0	174	520	13	24.30	50	36.96	CHANGED	hhlhhhhs..shsL.uGCGpKGsL.....Yh...P	........hlhllls....hhuL.oGCGhKGPLYhP..............	0	30	73	125
+13470	PF13628	DUF4142		Domain of unknown function (DUF4142)	Coggill P	pcc	Jackhmmer:C6QAI3	Domain	This is a bacterial family of unknown function.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.45	0.71	-4.15	144	804	2012-10-01 21:25:29	2010-12-06 14:02:49	1	5	412	0	357	1141	171	133.60	25	68.88	CHANGED	ss.Dpp.FlppAutushhElpuu+LAh.p+u.psspVKsFAppMlpDHspsspcLpplAp.....ptslsls......ttlstpppttl....spLpsh....sG.tsFDcs.Yhspt.lssHccsl...slhcp.h..sss......upsscLKsaApp.sL..PslppHLptAcpL	.....................................................t.t-tpFlppsstushhEl.puuclAh.p+.u.pss.p...........V+sFAppMlpDH....sp....ssppl.t.p.l..Ap........................p.t..slp.ls.......................tths.sp...tpshl....................spL..p.sh........pG.tsFDps.Ylptt.lssHpcsl...shhpp..h..tts......ucsspL+shApp.sl..PslppHlptActl................................	0	95	200	267
+13471	PF13629	T2SS-T3SS_pil_N		Pilus formation protein N terminal region	Coggill P	pcc	Jackhmmer:C6QEC4	Domain	\N	21.50	21.50	21.50	21.50	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.18	0.72	-4.45	188	1023	2012-10-03 16:25:20	2010-12-06 15:01:29	1	19	613	0	374	1013	88	71.40	24	16.39	CHANGED	sspslplshupupllph.spshpp..VhVusPplADspl.h.......ssp.....plhlhGKpsGsTslhla..spsup...lhshpltVs	.......................s..ttlplshupup..hlpl..s.p...s..hpp.......lhlu..sPplA.Ds.pl.h................ssp......pl.hlhG+.phGsTslhlh.....spsup..htshsltV........................	0	99	193	279
+13472	PF13630	SdpI		SdpI/YhfL protein family	Bateman A	agb	Jackhmmer:C7PMJ0	Family	This family of proteins includes the SdpI and YhfL proteins from B. subtilis. The SdpI protein is a multipass integral membrane protein that protects toxin-producing cells from being killed. Killing is mediated by the exported toxic protein SdpC an extracellular protein that induces the synthesis of an immunity protein [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.65	0.72	-4.27	205	1094	2010-12-06 15:14:03	2010-12-06 15:14:03	1	8	814	0	214	904	57	75.20	21	46.31	CHANGED	sphc.Nh.hhGlRTsho..........hps-csWcpsp+.......huG..hlhh....hsGll..hllhuhh................thhhhlhhhhhllshlls..hhhuh	...........................hc.Nh.hhGhR.osho..........hpsccsWctsp+..............huu....hlhh.......hsGll...hllhuhh...hh...............shhhhhhhhhhllh.hlhshh..............................................	0	82	154	180
+13473	PF13631	Cytochrom_B_N_2		Cytochrome b(N-terminal)/b6/petB	Coggill P	pcc	Jackhmmer:C1Z9G2	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.20	0.71	-4.46	68	102102	2012-10-03 10:28:09	2010-12-06 16:15:23	1	28	38793	95	787	97053	2443	142.10	66	51.21	CHANGED	.hhhlshhlHhhRshahGua+.ts+.phsWhlGlhLLlLshhpuFhGYsLPhs.hShhuhpl.hs.slhpu......lPhlG...shlh.hlaG.........G.hssss...hlsR.hash.Hl.llPhlllulhhhHlhl..l..pppspts............s..h...tp...ps.......sh..........st............hsaaPhashKs..h...hhhh.h...h...lhllh..........sls...........hlsP.....hh.hhsP	.......................................................ShFFIClYlHIG.R..GlY.YGSYh.a......pE.T..WNlGllLLh..hl..MuTAFhGYVLP.W.GQM.S.FWG.A..TV.IT.NLLSA....................lP..Y.lG..............ssL.Vp.WlWG....................G.F.S..V.D..s.A..........TLTR..FF.u..h.HF.lL..P..Fl.........IsuhshlHLlF..L...H.E.T.GSNN.....................................Ph......Gl...sS................ss...............DK...........................................IPFH....PYa.oh.KDl.....LGhh..l.h.....lhhLh...................Ls...........LFsPslLGDP......................................................................................................	0	232	504	660
+13474	PF13632	Glyco_trans_2_3		Glycosyl transferase family group 2	Coggill P	pcc	Jackhmmer:C6QI89	Domain	Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis [1][2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.46	0.71	-4.59	101	2553	2012-10-03 05:28:31	2010-12-06 16:25:28	1	20	1785	0	422	13191	1466	214.50	30	54.65	CHANGED	hllllDuDsh.l....sssplphh....st.h.ht..p..s......c.hs...hlQ...t...hh..s....h......s.h..p..sh..h.pphhshh.......h....sp.thhpthhhtt.shst.sss.......hs..Gssshh.chpu..l.p................cls..............has...st........slu.EDhchuh+L..h.ttG.....hph....has...............................st.s.......th.pct...ss..o.......................hts.hhp..........Q.ptR..WhhG......................................hh.........................................hh....h..........t.h.h.....tph..h...h...th...h.h................hth...h........hh.....hl.t......s..h...h.h......................hhhhh.....hh.h............h.....lhhhh..hh	...........................................................................................................................................................................................h....hDt.-sh.l......s.........l..h......................h....ht...p.....................................hs...........hh...............h........hh.......s.......................p.......p.......ph.........h....s..h...h....h......t..........................h..............h.....h..s....p...t....h....s.......s.....p..s......p..h...G.u....V..h.s............................s.s....G...s......s.A...h.Y..RR.SA...l.h.........................................................................................pst...............................................ha+..GcsS.............c.a..G...E..D...+...H.LTI.LM......L..cA..G...........aRT...........-YV...................................................................Ps.A.........ls..uTl.....VPc...o.........................................................lts...aLR............................Q...p..L...R....W..ARoo...............................hhp....................................................................................................hh......hh...................h.h...h.........hs..l....h.....t.........sh........s.s......................................lhl.......s............lu......sl..u......u..l..s.p.....................................................hhhsh......hh...................hhshhhhhhhh......................................................................................................................................................................................	0	153	264	364
+13475	PF13633	N_methyl_3		Prokaryotic N-terminal methylation site	Coggill P	pcc	Jackhmmer:C6Q9T5	Motif	This short motif directs methylation of the conserved phenylalanine residue.  It is most often found at the N-terminus of pilins and other proteins involved in secretion, see Pfam:PF00114, Pfam:PF05946, Pfam:PF02501 and Pfam:PF07596. It is often described as TypeIV_pilin_GFxxxE.	22.70	22.70	22.70	22.70	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	22	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.19	0.74	-7.04	0.74	-3.62	363	98	2012-10-03 10:38:27	2010-12-06 17:09:35	1	5	70	0	17	1401	206	22.00	46	13.90	CHANGED	aoLlElllulsllu.lshsshhs	.FoLIElhIuhsIlulhAhshh.....	0	3	7	14
+13476	PF13634	Nucleoporin_FG		Nucleoporin FG repeat region	Bateman A	agb	Jackhmmer:Q5A223	Family	This family includes a number of FG repeats that are found in nucleoporin proteins. This family includes the yeast nucleoporins Nup116, Nup100, Nup49, Nup57 and Nup 145.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.48	0.71	-12.53	0.71	-3.85	444	1433	2010-12-07 09:26:20	2010-12-07 09:26:20	1	64	197	0	1107	1448	4	103.60	29	24.15	CHANGED	s......sss..........s.........................sss....s.........u.....uhFG........s........ss.........s.........s...........s..................s.uh...F..Gs.........s..s..........................s.s...s.......ss........uulFG.......s.........s...s......t......................s..................ss.u........u..uLFGs......ss...........t...............t..s..s..............s..s........u..uL.....FG.....................s....s..s...t.................t..s......s.....s...s.uul..FGs....s.s....ss.......................................................................s.......sssuulFG	...................................................s............tssulFG...............s........pss..............s....s...........................uuLFGs.........s.ss..............t.....ss.s........su.........GGLFG...s......s..s...s.......................ts.............ssu......G..GLF.Gs....ss........s.................t..s...s........s.u........G.GL...FG.........................s...s.s.........t........p.s........ss......uuGL...FGs....s..s...ssp................................................................s.................................................................................................................................................	0	342	639	994
+13477	PF13635	DUF4143		Domain of unknown function (DUF4143)	Coggill P	pcc	Jackhmmer:B1L4V1	Domain	This domain is almost always found C-terminal to an ATPase core family.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null --hand HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.61	0.72	-3.81	579	2818	2012-10-11 20:44:47	2010-12-07 09:58:11	1	13	1059	0	687	2443	408	200.50	18	50.27	CHANGED	lpcD..lhp....h...ht...........hpsht..thpplhphlstphup.hshpplupthpssptsstp...............hhphhhthhhhhhh.shtspttpphtps.KlYhhDsGLhss.hhsh.........hh...............s..hGtlhEshVhpcLh...........pp.............t.laa....ac..................sp..st.....t..ElDh....ll.p.........ts.....ph......hslEVKtu	....................................................................................................................................................................................................................................................................h...Dh.t...t.......thtphhphhhsphsp.hshpphsphht.tttph.t..........................................................................hhphh.tshlhhhh..hphptppthtpt.KhYhhDsGLhss.hhshp.................................s..hGtlhEshVhp-Lh.....pp.....................thp..laa..a+..............................sp.....ss..........t...ElDall..p..p.......ss.....phhslEVK...........................	0	283	483	591
+13478	PF13636	Nol1_Nop2_Fmu_2		pre-rRNA processing and ribosome biogenesis	Coggill P	pcc	Jackhmmer:B1L5U4	Family	This family represents an evolutionarily conserved sequence motif of a set of proteins that are involved in pre-rRNA processing and ribosome biogenesis in S. cerevisiae.	23.90	23.90	24.10	23.90	23.80	23.80	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.25	0.72	-3.94	150	1049	2012-10-10 17:06:42	2010-12-07 11:38:25	1	3	1010	7	195	1177	35	103.90	35	24.07	CHANGED	lah.h.....th.t.s...h.pth.......+lhR.GlplGc..h....+Kp+acPoaslAh..s..............ltppph.pp..s...l-..L....sp..-....pht..pYlpG-sl......................pl...s..p............p...t.p..G.alllshcuh....slGaGKh..sss.plKNhaPKGL	...................h..hh...t.h.ss..l..spL....+lhRsGLcLGph......KK...pR...FEPSaALuh..u..........................Lp.s.s....p...s..pp..s...l-.l........sp..-......phhcYlpGEsl........................................pls.p............s..s.pG...ahl.lsh.c....Gh....................sLGFuKh....sG.s..hlKNhaPKGL..................	0	71	130	162
+13479	PF13637	Ank_4		Ankyrin repeats (many copies)	Coggill P	pcc	Jackhmmer:C6QI42	Domain	\N	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.74	0.72	-3.35	86	7425	2012-10-02 12:10:21	2010-12-07 11:59:11	1	2308	729	31	4885	95319	6198	53.50	28	8.01	CHANGED	thss..lphAsh.......psp..hph...lc.hll.....p..p..s..hs........hsth.....s..tt....st..s...slph.As...tts.....p....h.phlphL.l	..........................................................................................os.LahAut.................pGp.......hc.l........lc...hLl..................p....p....G......us.........................................lstp.........s.......pp........................Gt........T............sLah..As..........tpG.............p...........h.phlphLl................................................	0	2429	3032	3970
+13480	PF13638	PIN_4		PIN domain	Bateman A	agb	Jackhmmer:Q5AFK9	Domain	Members of this family of bacterial domains are predicted to be RNases (from similarities to 5'-exonucleases).	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.84	0.71	-4.05	147	2263	2012-10-03 20:43:45	2010-12-07 14:09:18	1	39	1676	9	998	2073	447	140.90	26	23.81	CHANGED	aVLDTNVLl..cc.pslhp..h.............................pcpp..llIPhsVl-ELDphKpppp.......................plsphs..c...............ps.h....p...hlppt........hptt..........................t..sp.l........ts.....pph.......................pp.pl.....t...........................p............p..sDsp..ILssshthppph..........................tppl..lLlocDhNLRlKAps.hGltup........s.ap	.................................................................hVLDTNVLL.....p.c.....s..p..s..l.h.p.h...............................................................pcpc...V.llPhsVlcE....LDthK+ttp........................................................clupp.A.R...............p.s.h..+...hl-ph.....htpt.......................................s.tph..........hh.ppt.......................ptph....p............................................p.......tpsDs....p......ILsssht..lppch...................................................................................tppV..lLVoc.DhshRlKApu.hGl...spph...........................................................................................................................................	0	359	614	836
+13481	PF13639	zf-RING_2		Ring finger domain	Bateman A	agb	Jackhmmer:Q5A9Y7	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.26	0.72	-4.13	329	15070	2012-10-03 15:03:13	2010-12-07 14:28:22	1	495	529	19	10132	21355	1292	45.90	34	10.07	CHANGED	tpCsIChpph..................t.ppsh.....tl......s..C.........s....H.h.FH....tp....C...lpp....a...........h..............p...p......p.......t.....................pC..Ph.CR	....................................pCsIChpph..........t........................tcpht..........hL...................s...C.......................s...H....h...FH....tp........C....lpp......W............................l............................p..p.......p.......p.....................................................sC..Pl.CR................................................	0	3177	5561	7989
+13482	PF13640	2OG-FeII_Oxy_3		2OG-Fe(II) oxygenase superfamily	Bateman A	agb	Jackhmmer:B8H030	Domain	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.84	0.72	-3.49	172	3739	2012-10-10 13:59:34	2010-12-07 14:54:39	1	75	1689	20	1686	4120	5084	99.90	24	31.62	CHANGED	htlphh.psGshhs................hHhDs............................sp+tloh...lha.Ls.sp..................pGGplphhst.........................hssh.ttlt...............PphG.plllFpu..........ppshHtVtss........tst..pRhslssaht	.............................................h..h.pY..tsG.p..tat.................................hHh.Dsh.....................................hsp+pl.oh...llY..Lstsp....................................cGGchhhhs..............................................................................tt...tplp.........................PttG..pl..llF.u................psh.HpVpsV..............tpupRhuhshWh.....................................................	0	587	994	1366
+13483	PF13641	Glyco_tranf_2_3		Glycosyltransferase like family 2	Coggill P	pcc	Jackhmmer:C6QF57	Domain	Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis [1][2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.29	0.70	-11.59	0.70	-4.56	37	8712	2012-10-03 05:28:31	2010-12-07 15:09:08	1	130	3503	4	2974	39049	8776	233.50	18	43.38	CHANGED	Pp..lsllls.shppss.....hltc...slp..shl..s....t..a....sp..hclhlhs..ps......ss....pts.h....p...h.hp....thttths..sht..hp.hl.t...s...p....G.tsKstsl.tpshp..t...........h..p.........sc......hlslhDuDshl.ssss.ltthhshh.........tp.......phshlp.s.h..hs...p..s...tp......sh.......................hs.h.....s.......h.chstpph..thhhhp.....pt.....h..s..h.s.s.h..s....G.ss.hhhcpssl..pcht.............t......hs.............hhhs..-Dh..thshpltp...tGhpst..h..h.....s.tsh...............shph......ts......ps....hts.hh+pptRWhhu	....................................................................................................................................................................................lslhl.s..sa..s..Et...............sl.tp........slp.......ul..h......t.........s...a..............sp........hclh.l.l.s.....Ds............................s.s.............-..p..s..h.........................p..........h...h....p............................t...h..........t....t.......h.s......t.h....................h.p....h....l.t.t..........................s.............p........s.................s..K......u.....t..s...l....st..u.h.p.....t..........................................................................s..p................................s-............hl..h.lh..........D.u..D....sh....h...s.....s....s...h...l.t.p..h.l..s.hh.............tss............................pl..u.....h.....Vp...s....h.......th.............t.....s.......ts................sh.....................................................................h.s.p.h.........tp...............h...p...h.....t.....h....h...h..t........h..h...t....t...s.p........................p.t.........................h......s......s.....s....h....h........s.............G...s..........s....h.......h...h....R..+.....s..s..l.......c.p..l.G.................................................................................u......ass.............ts.hs...ED.h......clu..h.+..l...tp........t......G..a......p.....hh......a.......h...........s...ps.h.........................................s.h.t................hs..............ts..........htt...hhtpp.RW............................................................................................................................................................................................................................	0	902	1889	2484
+13484	PF13642	DUF4144		protein structure with unknown function	Serrano P, Geralt M, Mohanty B, Horst R, Wuthrich K	kellrott	Shewanella amazonensis SB2B PDB:2L6O	Family	A family based on the three-dimensional structure of YP_926445.1 (PDB:2L6O)	27.00	27.00	28.80	28.40	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.43	0.72	-3.68	25	104	2010-12-07 17:52:53	2010-12-07 17:52:53	1	2	92	1	28	77	3	100.70	41	86.07	CHANGED	WPulLKhsGcDELlYLsSpp-a.pEs..pphhhsssDhLIDSpGpsYtlpp................ssptssLhhpsphlslpclhpLlpsHshtpupsCssKltFsolpQul-hls	................................................WPslLKL-GDDELlYLsScsDhpsEs...shIhsssDplI..DSpG.sYsl.s................ssstssLhtpspplSl-EsocLIQpHEFsLApsClsKIpFpTlspAhpsL...	0	6	10	19
+13485	PF13643	DUF4145		Domain of unknown function (DUF4145)	Bateman A	agb	Jackhmmer:C7Q403	Domain	This domain is found in a variety of restriction endonuclease enzymes. The exact function of this domain is uncertain.	21.70	21.70	21.70	21.70	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.09	0.72	-4.13	91	970	2012-10-01 22:14:54	2010-12-08 10:52:41	1	24	854	0	191	795	46	92.90	23	13.40	CHANGED	pcAt.phh.t.s.s.....p.uuu.....shhRpsLEtlhcchs........t.....psp.....................s..........L.........tpcIsplhpps......stpl..tchh.....................cs...lRhlGNpusH...s.....p.........p.lsp.........p.D....stphhc.hlc	.............................h..Acphht.s.s.s.p.sss..hhhRpslEthl+hlh.........p.....psp.....................s..........L....pshlpp...hshpsh.....lsspltp.th.....................chl+phGNpAsH....s.....t............chst.........c-....u.hhhp...h.............................	0	57	112	150
+13486	PF13644	DKNYY		DKNYY family	Bateman A	agb	Jackhmmer:C2M6R1	Family	This family represents a group of proteins found enriched in fusobacteria. These proteins contain many repeats of a DKNXXYY motif. The repeats are spaced at about 35 amino acid residues intervals. These proteins are likely to be associated with the membrane. The specific function of these proteins is unknown.	22.50	22.50	22.50	22.60	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-12.04	0.71	-3.98	31	664	2010-12-08 11:29:52	2010-12-08 11:29:52	1	11	134	0	233	689	10	122.90	17	66.51	CHANGED	asKD+splYYhs.......c.....clcs......sDs........poFch.......ls.......c......p..a....spDKsslYh....tspp..l.........shs..spsh...chl..............spp.....hhtp...stsphh..............hhp..hpp.............t..p...............hpsls.tYht.DKpplYa........t....t..phchlc.......shDhp.........ohc.ls...sh................aspDcsslYa....ts...........p.............plpssDs..soFchl...............s.t..hah+DKsp.lYh..t.s	.......................................................................................................................l.t..s..........oh............ht....................h...........hDp.thYh.....t....h............................................................................................................................................................................................................t......a..........................................p............th..t.t......sh...p.h.................................................hhpDtpplYa.....t..................................p...................................l..ths...tsht.l..................t......h....hDt........t..................................................................................................	0	78	218	226
+13487	PF13645	YkuD_2		L,D-transpeptidase catalytic domain	Bateman A	agb	Jackhmmer:C2M5S1	Domain	This family is related to Pfam:PF03734.	27.00	27.00	27.00	32.50	26.40	24.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-10.99	0.71	-5.04	56	379	2012-10-02 23:30:06	2010-12-08 12:37:36	1	3	278	0	115	362	40	172.30	39	70.48	CHANGED	applph..p.spl.shpshppAlpuapplppp..h...ppslLTlIDaopPSsp+RhaVlDlppp+lLapohVuHG+NSG......p.ph...A......spFSNpssShpSSLGaYhTspTYpG+pGaSL+..LpGLEcGhNDNAppRuIVlHGAsYsspsaI+ppGRLGRShGCPAlP.plscplIcsI...KsGoslFlY	............................h.......tstl.shpshppAh.puhp.phppp.......ppslLslIDaSpPSsccRhaVhDlcpc+lLapshVuHG+......sSG......p.ph...A......spFSNpssShpSSLGhahTt.ps.Yt..G.cpGhS.L+..LpGLEpGhNDpAccRsIVlHGAsYss......s..hl........p.p.h......G.+LG.RShGCPAlstp.lsc...p...lIstl...KsG...s...llahY..............................................	0	47	79	102
+13488	PF13646	HEAT_2		HEAT repeats	Bateman A	agb	Jackhmmer:C2M4W3	Family	This family includes multiple HEAT repeats.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.37	0.72	-3.70	323	11825	2012-10-11 20:01:04	2010-12-08 13:16:31	1	572	2216	18	5662	13686	1691	88.30	20	24.50	CHANGED	h.p...hLhp.h...L..p......ss..ss...t....l.+.t.t.uh.psLu.............p.h..t..s..t............ps.............................hshLh.p.hl........p..s...s..s....s..t.....lRttAs..p..uL....u....p..h............s..........s.....s...p....s....h.....s.hLhp.......h..h.ps..s..s..s..t...h.hR..ts..s...hp...uLt	...................................................................................................hhth.l..p.......st..s....t.......l..R....t..t..As.tsLu....................................p.h...t....s..t...............ps..............................................................................................lshLh...p..hL..................p...D.....p....s.....s..t..........VRttAs..t.....uL............u......p...l.................................u.............................s.........t..p...........s.......l...........s..hLh.p.............h...h...ps...p..t...............hp..................................................................................................	0	1805	3521	4730
+13489	PF13647	Glyco_hydro_80		Glycosyl hydrolase family 80 of chitosanase A	Naumoff D, Coggill P	pcc	CAZY:GH80	Domain	This is a small family of bacterial chitosanases.	25.00	25.00	616.50	616.40	19.30	18.00	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-11.95	0.70	-5.16	3	15	2012-10-02 14:50:22	2010-12-08 13:22:11	1	1	13	0	0	15	0	297.50	91	89.83	CHANGED	AAAAAGVIPVGDSRVYGNVFDKGRKLTVNQWQAVLSMDAYPENGTTNYQDPEPWRYCEVDYEAuEGISDYRGDTFGPVGVTTVGDFPDYFKNAYAPYVLGKTGATNTDMKNWGVQVTGIAAADMKADDTRLDPYPNLSRSNSKKRAALTKICQALQSDFDNRQAQYVMSHYAHIDSDKLLPVLDALKKIGFTSFuQYNLVGLAFQVQVNTGSIGSISAFSSVKSAGNCGSMSuETCFATYLTDQYIRWLKSSSLGDDsGNCWRASMALDIYKQDPTMGNVSVVTSIINSKYPNNSGKCPTSGVKWSKN	..AAAAGVIPVGDSRVYGsVFDKGRKLTVNQWQAVLSMDAYPENGTTNYQEVGPWRYCEVDYEAAQGISDYRGsTFGPVGVTTVGDFPDYFKKAFAPYVLGKSNATNADMLAWGVQVTGVTAGNFpADDTALDPYPS+SRSDKsKRAALTKICGALQSAFDTQQDKYVMSHYAHIDQDKLVPVLNALKGIGFTAFDRYNLVGLAFQVQVNTGSIGSISAFSSVKSAGNCGSLSAETCFATYLTDQYIRWLKSSSLGDDPDNCWRASMALDIYKKDPTMGSVSVVNQVINASYPGNSGKCPTSGIKWSKN.	0	0	0	0
+13490	PF13648	Lipocalin_4		Lipocalin-like domain	Bateman A	agb	Jackhmmer:C2M763	Domain	\N	22.40	22.40	22.40	22.40	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.97	0.72	-3.41	116	502	2012-10-03 08:47:39	2010-12-08 16:03:31	1	7	182	0	164	533	83	115.20	14	70.75	CHANGED	hhsu.Cus-..-c.....ps.............pss............................lh...G....s.Wpls....p..h.s........tts.t..............................t...ts.h.........sps.ptshhpap..s..s........s.hstt..php......ss.......t.th.t..t..............tpsssasls..ss......pl.slph..............pss..t..t...tp.......hp..hhp......l....s..sspLsh	................................hhuCssc..cs.....ps.............pss............................lh...G....s.Wpls...ph.s.........httt...........................................p..tth.........sps...ptsthpFp..s...s............s..hstt...php......ss.........h..t..t..................................ppstsaslp..ss......pl.phph....................t.p.s..t.................h..hhp......h..s..tpph......................................................	0	68	136	164
+13491	PF13649	Methyltransf_25		Methyltransferase domain	Coggill P	pcc	Jackhmmer:B1L4J9	Domain	This family appears to be a methyltransferase domain.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.54	0.72	-3.65	78	1216	2012-10-10 17:06:42	2010-12-08 16:37:45	1	39	965	11	462	43237	12860	101.60	19	35.92	CHANGED	lL-luCGsG....h..h.tt....hhpt........................h....t................hphhs...lDhspctl..........................ph..sp....................cph..........h........phc.h......ht.....sch......pp.....l........s..........h........ttt..pFDhlhs..................sh.hs.........h.hsptthhphhpchsp.hh..c..s.G	............................................................................hLDl.uCG.s.G....t...h....h...th....h.h.t....................................................h.....t..................tph..hs......lDl......s...p.......p.h..l......................................................ph....up....................................................................pph..................................pl.p...h......lh...............u.Dh......................pp.........L.............................................s............................h.....................tst.....sa.c..l....l.hh...............................................hs.t..hs..................h...h.....t..........p.....p......h......t....t..h.h.p.....ph.h.p.h.l.t.t...............................................................................................................................	0	133	259	371
+13492	PF13650	Asp_protease_2		Aspartyl protease	Coggill P	pcc	Jackhmmer:C6QGC6	Domain	This family consists of predicted aspartic proteases, typically from 180 to 230 amino acids in length, in MEROPS clan AA. This model describes the well-conserved 121-residue C-terminal region. The poorly conserved, variable length N-terminal region usually contains a predicted transmembrane helix.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-10.02	0.72	-3.48	300	2359	2012-10-02 15:32:34	2010-12-08 16:43:30	1	147	973	0	1248	4331	281	91.40	19	17.90	CHANGED	l...sspl....s.G......p..s...h...phllDTG.A.o.t..s.sls....pp..hu....c.p.l.....u.l...ph..t..sh.t............ht.s..p..s...u..s.G......p..s.p.s..t.h...s.p.ls...p..........lp..l..G.s........h.p..hp.sl........p.......s.hl.hs.............s.....t.....h...s........s.......ul.......LGhsh	.......................................stl....s..G......p...s..h...phllDTGA.s.s...s.hls....ps...hs....c.c.l..........u.l...ph..p..s..h......................hth.....p..s...s..s.G...........p..s..p...s....t.h...s.p.ls.....p.............................l..p..l...G..s.................hp...h.t...sh........p..........h..hlhs........................................t................p........slLGhs...........................................................................	0	480	794	1052
+13493	PF13651	EcoRI_methylase		Adenine-specific methyltransferase EcoRI	Bateman A	agb	Jackhmmer:C2M8X9	Family	This methylase recognizes the double-stranded sequence GAATTC, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the EcoRI endonuclease.	22.60	22.60	24.20	24.00	21.00	20.80	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.13	0.70	-5.36	12	164	2010-12-08 17:00:59	2010-12-08 17:00:59	1	6	134	0	31	164	89	237.20	38	88.75	CHANGED	psLpcA+pu..KsDEFYTphsDIEpElpaYhpa....FcsKsVLCNCDDPhcSNFhKYFAhNFspLGLKKLIsTsYusss.........................s.......phs..........ps......csp.pshhh..-h-.t..s..psschs...............schphphLpGsGDFRSpEslcLLc-uDIVVTNPPFSLFREaluhllcYcKpFlIIGN.NAITYKElFsLI+cNKlWLGhph..GchtFtVPDtYE.....ctTchhlDEsGp+apphuNspWaTNL-ht+RH.EsL.Lh..........++Y..tc....cpYPKYDNYDAIpVs+sp-IPhDYpGlMGVPITFlcKYNP-QFEIlG.htps..t...............................h.h..ss..cpc.h....hlNG..K...phYtRILI++K	.......................................p..LptApt...KpDEFYTph.-IcpEhthY...ph....FtsKhlhhsCDD........s..........Ss........FhhaF..pFtthtlK+Llsspa................................................................................................tt..h..htts.....GDFcStEshp.lhp.p.uDIllTNPPFShFcEals.Lh.ch.pKpFllluN..NulT.YpchF.LlppN+hWhGhth..u...FhlPpth.........tt.t.h....ct........G......t.hhp.tshhWhTNl-..hRp..p.l.Lh..........pph........ptY.hYDsa.puIpVs.h.tIP.Da.G.MGVPlo.Fhp+asP.pQFcllt...t........................................................................t...................ps...p.......a.Rlhlp...................................................................................................	0	6	20	24
+13494	PF13652	DUF4146		Domain of unknown function (DUF4146)	Coggill P	pcc	JCSG_target416819	Domain	This is a family of short proteins which appear to be pre-cursors. All members are from Pseudomonas spp. The function is not known.	21.80	21.80	22.40	180.80	21.20	20.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.65	0.71	-10.21	0.71	-4.25	11	61	2010-12-08 17:32:18	2010-12-08 17:32:18	1	1	61	1	15	44	4	112.00	72	81.75	CHANGED	ASLpEaELs+MLEKVA+ESSVGTPRAINEDILDQGYTVE.GppLlNHLSVRpuHAppMRuNPcsVRsQLGsSVCpNsGYRpLMuKGAVh+YcFTEYKTN+PVsoppFsuuDCs	.AShp-FELSKMLEKVAKESSVGTPRAINEDILDQGYTVE.GNpLINHLSVRpuHAppMRuNPDsVRsQLGsSVCpNsGaRQLMu+GAVLpYpFTEYKTNpPVATppFpAusCp.	0	1	3	10
+13495	PF13653	GDPD_2		Glycerophosphoryl diester phosphodiesterase family	Coggill P	pcc	JCSG_target396624	Domain	This family also includes glycerophosphoryl diester phosphodiesterases as well as agrocinopine synthase, the similarity to GDPD has been noted [1]. This family appears to have weak but not significant matches to mammalian phospholipase C Pfam:PF00388, which suggests that this family may adopt a TIM barrel fold.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.92	0.72	-7.25	0.72	-3.66	73	257	2012-10-01 22:17:21	2010-12-08 18:04:34	1	7	110	10	44	1089	478	31.20	49	10.52	CHANGED	+VhhW.os...........Dp...............s.........sh.........pphh.shGVDtlhTspss	....KVYaW.Tl...........DK.........cu.....oh........RcuL.cAGVDGlMTNaPs...	0	17	31	38
+13496	PF13654	AAA_32		AAA domain	Coggill P	pcc	Jackhmmer:C6QHL0	Domain	This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.	25.80	25.80	25.80	26.00	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	509	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.64	0.70	-5.84	125	1541	2012-10-05 12:31:09	2010-12-09 13:32:27	1	8	1299	2	408	1140	169	341.70	25	52.08	CHANGED	Tp-L.ssh.....pt.hlGQcRAhcAlcFGlul.cppGYNlalhGtsGoG+pohlpphLpctA...cp...ssPsDWsYVtNFcsPcpPtsLpLPAGpGpphccDhcpllcpLtpslPpsF-u-cYpp++ppltcpappcppphhpplpcpApcpGhsL.hpossG....hs....hs.Plp...........-.G.........cs....lsp--a......ppL...............sccc+cplc..pphppLppclppllpp.lpph-+chp-clccLc....cclst.slsphl....p....pL+....c+Ypc...h...sclhpaLcslpcDll-Nlp.Fh...............t.tp.......tt...tpt..p...................RYpVN.l.lV.DN...s.......................pppGAPVVhEssPoapNLhGcIEatsphG.slhTDF......ohI+sGuLH+ANGGYLllcAcclLppPauW-uLKRAL+opclpIEsh.....ths........so...h......oLcPEPIPLclKVlLlGs..lYaLLtpaDs-FpcLFKVpADF-schsRss-shppaAphlushsccpsLh.h-+sAVA+l..lE..au..uR.....spc..+..LSs+hspls-LlpEAsaaAptpssphlpspaVcpAlpt+phR	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sphtpLhGp.lc..s..............s..s.h........h...l..pPGhlHpANG.GhLllshpsLLspP....h.....h....W.tLKphlppcchc.h.uh.....s.s......pslslps.sh..P..LclKlILlG-.ccthtt...hpch-P-.ht.c.hht...lh..u-F-.cplp.h.s.s.E.s.h.p.p.a.spalsp.hsp.c.p.p.L..sh.st.s.AhstLlctusR..h......spc...p..LsLp.......l..tp..hl.t-.us.hs........t..............h...p..tl..s.......................................................................	0	112	246	345
+13497	PF13655	RVT_N		N-terminal domain of reverse transcriptase	Coggill P	pcc	Jackhmmer:B3CUZ7	Domain	This domain is found at the N-terminus of bacterial reverse transcriptases.	27.00	27.00	27.20	27.30	25.80	26.40	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.72	0.72	-3.92	152	753	2010-12-09 14:12:41	2010-12-09 14:12:41	1	5	321	0	163	711	23	79.10	44	18.14	CHANGED	Wp.........sIsWpplccpVh+LQpRIhKAsppGchp+V+pLQ+lLh+..SasAKhLAVRRVTp.Np..............GK+TuGVDGhhhho....Ppp+hphhpp.....Lp	...................WpsIsWpcspppVh+LQpRIh+AsppGphtKV+pLQ+LLs+..SahA+hLAVRRVTp.Np..............GK+TuGV.DGhhh.o....spp+hphhppL................................	0	42	115	138
+13498	PF13656	RNA_pol_L_2		RNA polymerase Rpb3/Rpb11 dimerisation domain	Coggill P	pcc	Jackhmmer:B1L7Q7	Domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer.  The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000).  Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037).  Rpb11 is found as a continuous domain.  Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.	27.00	27.00	27.00	28.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.35	0.72	-4.54	53	756	2012-10-02 13:35:44	2010-12-09 14:24:54	1	6	450	90	495	763	147	75.70	37	58.93	CHANGED	sphphplpsEDHTLuNsLpphLhcs.scVpFsuYsl.sHPh........pschpl+lpoc..ss.........sshcslcculpclhshscplpppa	.............sspFplpcED.HTLGNhLRhhLh+..........s...P........pV.F.uGYpl.PHPh.............-s+hhlRlQTp..ssh........................................ssh-AlppulpcLhs.hshlpcpF...................	0	149	262	401
+13499	PF13657	Couple_hipA		HipA N-terminal domain	Bateman A	agb	TIGRfams	Domain	This domain is found to the N-terminus of HipA-like proteins.  It is also found in isolation in some proteins.	22.50	22.50	22.50	22.60	22.40	22.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-10.44	0.72	-3.70	185	1769	2010-12-09 14:38:03	2010-12-09 14:38:03	1	10	1109	8	541	1574	195	102.00	24	26.72	CHANGED	LpVhlp.s....p....hlGpLp..p.s...ss....s.....hpFpYsssahs....s..uh..sl..S.l....sh......Plp............sp.................s.a..........p......s..........p.......sl.s.................aFssLLP-uh....hpc.....hl.....sp.....p..h.....phs.....sts..shsl.....L.thlG.p.-.shGAlphh	................................hht..s......p.....hlGpLs...pp.......ss..s.....hpFpYss....palt....t......uh..sl...S...l....sL......Plp..............pt.................sh..................p...s.....p......slhs........a..FsshL...PDuh......hRc.....hl.........tp...c.h..............php.........stsshsh..........L.thl.G.p.c.s.hGAlph.h..................................	0	136	313	436
+13501	PF13659	Methyltransf_26		Methyltransferase domain	Bateman A	agb	Jackhmmer:Q9YEM1	Domain	This family contains methyltransferase domains.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.41	0.71	-10.74	0.71	-4.06	167	9512	2012-10-10 17:06:42	2010-12-10 15:35:54	1	120	4267	26	2887	64631	10679	155.40	18	26.58	CHANGED	ss......plL-PusGsGt.h.h..thhh.pt................................................h........sphhul.El.ssh......................................................................ssph...sp............................th.....h.t............t...t....h.............................................................................................................p....hhtsc.h..t.ph.....................................................t.....h....t.s.....s.p.............h-hlltNs.Pa...................s.....t...............t.t.........t......t...........................................................................hhp...............th.l..tps.hc.hLpsu.Gh.lshls....s.......s	...................................................................................................................................................................................................................t..pllDh.us...G....o.G.s....h..h....lhhs..pp................................................................................................................h........tsplhul.E.l.....s.s.t........................................................................................................................................................................................................................................................................................................................................s.s...p.h....Ac........................................ps......hth................s....t..h.........................................................................................................................................................................................................................................................................................................................................................................................................................t....t.......h..p........l...h...p..s..D...h.....h..ph..................................................................................................................h............h.......t..s..........s...p...........................hD....l...l...l....s...N...P...P.Y...........................................h..t.t.........................t....t..t.........t...t......p................................................................................................................................................................................h.hp.................th..h...t...t.u..h.......p...h.L...p............s...Gh..hshh...p............................................................................................................................................................................................................................................................................	0	966	1897	2456
+13502	PF13660	DUF4147		Domain of unknown function (DUF4147)	Coggill P	pcc	Jackhmmer:B9Z5Y2	Domain	This domain is frequently found at the N-terminus of proteins carrying the glycerate kinase-like domain MOFRL, Pfam:PF05161.	23.00	23.00	24.90	24.70	22.30	21.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.53	0.70	-5.26	229	900	2010-12-10 20:10:12	2010-12-10 20:10:12	1	9	749	3	400	860	424	223.20	39	52.89	CHANGED	phlpplFcuAlpAupPtpsltptLst..p.....................................s...tG+slVlGuGKAussMApAs.-phh........ss.........p......l..p.GlVlT+a.........Ga....s..t..........s......h...p......................p..l...cllE...Au.HPVPDpsulpAuccllchlp.....s.l.stcDlVlsLlSGGGSALLshPss........GloLtDKpslsctLLpSGAsIsEhNsVRKHLStlKGG+LAtss..tP..A..cVloLllSDVsGDc..s.sI.......A.......SGPTlsDs..o.ThtDA..hsllc+Ysl...plPs..s.ltphLpps	..............................t..hpplapsAlsAspPttsltttLs.p.......................................spu+slVlGsGKAussMAtAh.Ephh........ss..........p.l...p.GlVlT+.a.........Ga..s..s.......s.....s.p......................................cl..cllE...Au.HPlPDtsulpAupcllphlp.....s..L.s.t.cD....lVlsLlSGG.GSALLsh.Ps.t........GloL.........p-cpsls+tL.LtSGAsIsEhNsVRKHLSt.lKGG+LAtus..hP..A..pVl...oLllSD....VsGDsss.hI.......A.......SGP.T....VsDs....o.o.....h.....t-....A..htllc+Ysl...plPt..slhthLpps................................	0	128	241	326
+13503	PF13661	2OG-FeII_Oxy_4		2OG-Fe(II) oxygenase superfamily	Bateman A	pcc	Jackhmmer:B8H030	Domain	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.35	0.72	-4.34	39	165	2012-10-10 13:59:34	2010-12-13 14:17:58	1	7	132	0	81	1691	1412	68.40	19	21.49	CHANGED	hsshhsst...............h.hhthtpsshhphHhDtpstts.......................huhllYLs...thsscasGuphhh.cpssptt	......................................................hht........................thhphstu.tp.hshHhD.s.sstts...........................h.hohllYL.s........t.ts-at.....GsphhF.c.ts...h.................	0	36	64	72
+13504	PF13662	Toprim_4		Toprim domain	Bateman A	agb	Bateman A	Domain	The toprim domain is found in a wide variety of enzymes involved in nucleic acid manipulation [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.42	0.72	-3.97	195	9626	2012-10-01 21:47:57	2010-12-13 14:48:10	1	67	4702	9	2135	8279	5737	85.30	27	20.04	CHANGED	stlhlVEGhhDllulcps...shpsshts.......lG...ssl...shpplt..phph................................pclllshDsDh.........sGppsutt....htc..........h..t.shplshls	............................................................t.plhVVEuhhDVhA......l....cps.....sh.........p..s...th.t.s.........................LG.....ssl.......sh..-t..lt.....chth.....................................................................................pclIlsh.-sst............................sGcssAhhhhc.........hhh....shth...................................................................	0	703	1405	1799
+13505	PF13663	DUF4148		Domain of unknown function (DUF4148)	Coggill P	pcc	Jackhmmer:A9BSV2	Domain	\N	22.10	22.10	22.20	22.30	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.95	0.72	-4.12	203	1134	2010-12-13 15:52:52	2010-12-13 15:52:52	1	3	104	0	396	1029	56	61.00	30	62.98	CHANGED	ussl..ssshs..........uh..A.ps.............s...lTRAQV+AELhphcpsGh...Ps...ts.s......Y.Pssh........p...s.Aps.plss	................................................hs...h..sssss..........................uh..utps.........................slTRAQV+uELsphcpsGh....tss....ssps.......Y.Pssh........ts.Attp........................................	0	20	104	254
+13506	PF13664	DUF4149		Domain of unknown function (DUF4149)	Coggill P	pcc	Jackhmmer:B9YZD8	Domain	\N	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.27	0.72	-3.95	178	975	2012-10-01 21:57:53	2010-12-13 16:57:40	1	3	879	0	341	687	671	99.80	23	53.21	CHANGED	LhhuhhhGuhhhhu......als................uPhlFps...L.....s+t.psGtltspl................Fshahh....hthsssslhhlhthhth.............h.t..t..hhthhhlhshhlhslhsthhltPhhsphptpttp	...................................hshhhGu.lh..hs......a.ls................u.hlFhs........L..........s+h.psGphtspl.................F.hhhh....lhhsssllhh.hhhhhsh.......................t..h...h.hlllshh.lhslhshahltPhhtphpptt..t............................	0	84	194	285
+13507	PF13665	DUF4150		Domain of unknown function (DUF4150)	Coggill P	pcc	Jackhmmer:A9BLL6	Domain	\N	27.90	27.90	27.90	29.30	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.34	0.72	-4.16	83	382	2010-12-14 12:40:17	2010-12-14 12:40:17	1	24	235	0	135	304	15	106.30	32	34.40	CHANGED	sGhsh.uhPDVChT..P..........lPlP..YPNhuhssssh.s..sstsVhhsGtPshshs.ohh.shosGDp.uGss..tGVhSGslhGtschh..stS.sVhhcGpsssRhsDhshpN....ssNssGt	..........................hsh.shPDVChTPs..s......lPlP..YPNhAhssssh.s..ssssVhhsG.ts.shshs.ohh..shosGDpuGst.........tGVhSuT.lpG..p..schh..stSssVhhpGpsssRhsDhshhN....ptNs.s.h..............................	0	35	71	104
+13509	PF13667	ThiC-associated		ThiC-associated domain 	Coggill P	pcc	Jackhmmer:B9Z987	Domain	This domain is most frequently found at the N-terminus of the ThiC family of proteins, Pfam:PF01964. The function is not known.	27.00	27.00	27.20	27.20	25.80	26.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.80	0.72	-4.42	217	1951	2010-12-14 13:42:45	2010-12-14 13:42:45	1	4	1913	6	496	1521	213	79.30	48	12.96	CHANGED	tshPsS+KlY.lpGs..+sDIRVPMREIsLosT.............s.........pt.....NsPlhVYDTSGPYTDPsspIDlcpGLP.plRpsWItcRuDsEp	..................t.saPsS+KlY....lpGo....ps-..l....RVPMREIpLosT.h..t.st.........ptNtslsVYDTSGPYoDPph..t.....IDlppGLs.cLRpsWIptRuDsE.............	0	124	292	401
+13510	PF13668	Ferritin_2		Ferritin-like domain	Coggill P	pcc	Jackhmmer:A9C0V0	Domain	This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.60	0.71	-4.22	124	660	2012-10-01 21:25:29	2010-12-14 13:44:48	1	9	316	0	446	1025	61	140.50	24	45.49	CHANGED	sDhclLNaALsL..EaLE..............spFYptu.htt.............................sushsssh.....hshhpplttcEhuHlchLpssl......Gsps.......l......sps......pa.....ca.............................hssas.s.......ttsaLtsAtshEssGVsAYhGAus.hls...sts....hLpsAuuIluVEAtHsuhlRshltp	....................................................DhplLphALsL..EalE..............t.saYptuhtths..................................tsshssts.....hphhpphsppEhuH.sp...h.Lpssl...........Gsps...............s..........sps..........p.a.....sa.................................................................shs.s........stsalt.h.ut........hl..Ep..sGsuuY...hG...sss...hls..........sps....h...hp..hsu...slls...sEApHtuhlRph.....................................	0	159	312	398
+13511	PF13669	Glyoxalase_4		Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	Coggill P	pcc	Jackhmmer:A9C2R0	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.42	0.72	-4.04	77	2150	2012-10-02 15:00:03	2010-12-14 14:45:10	1	24	1580	20	829	7043	2394	114.10	24	65.97	CHANGED	pplulsVt...Dl-pshpha...sphlG............h........p.....h..............h..........t.p.h........h..s.............p..............s..............p................s..............s........s..h.........s......h.h.th.sss.....hpl..ELl.p.....Phs.....ss.....s.hpt.......ptsu.lp..Hl.uhh..s...c...D...l-ssltthpp.p..Ghp..hh....t.s...tt..u...s.s.s.tc.hsa	.................................................................pHluluVt...D..l-pAhphaps...hL...G.............h............p......h.......................h...............t..t..................t..s......................p............................p......................p.....................s.................................V....................c...s.........................s..........h...l...th...s.ss.................pl...E.L.l...p........Phs.........ss.......................phlpp...........................pusG.l..a....Hl..Aac......V....c......D....l..c...s...s...h...p...c...Lcp...p....G.hc..ll.....tp..t..sph..G...s.t.s.t.lha................................................	0	282	568	711
+13512	PF13670	PepSY_2		Peptidase propeptide and YPEB domain	Coggill P	pcc	Jackhmmer:C6QGP5	Domain	This region is likely to have a protease inhibitory function (personal obs:C Yeats).  The name is derived from Peptidase & Bacillus subtilis YPEB.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.78	0.72	-4.08	83	928	2012-10-01 23:09:26	2010-12-15 11:13:51	1	7	550	0	229	873	47	80.40	22	77.90	CHANGED	hhhlshssshhu...usAhA.........sspsPtspWh..stsplpptlpp.pGa.plcclcht-sts...aElc.uhspsGc..+hElhlDPtotpllcpc	...................................................................hh...hhhhhhh.u...........ssAhA...................pstt..s...sph.............shsps.tp.h...l.pp....pGa..plpclch..-...c.us...........YElc.s..ts....p..sGp..ch-lhlDstohcllp..................	0	52	120	174
+13513	PF13671	AAA_33		AAA domain	Coggill P	pcc	Jackhmmer:A9BWH5	Domain	This family of domains contain only a P-loop motif, that is characteristic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.74	0.71	-4.31	146	4032	2012-10-05 12:31:09	2010-12-15 11:19:46	1	83	2093	32	1521	12436	3403	138.60	17	34.96	CHANGED	lllhsGhsGSGKooh....spp.h....htth....s........hhh.lspD.s................................h+p..phhs..........tt.t.....p..................................t.......th...sht....hhhphspthL.ptG...ts.s.ll......D.sT.........slp.....t.ppR....p.thhpl..Ap..phus.............h.ph.lhhpss..phhtpR...............tpRptp.................p......ssttslpphhpph..c..P	.......................................................lllhtGhsG.oGK.oTh................ucp...l....................ttt.hs.......................hhh...l.s.p...D.s.....................................................................................hpp....phts................tt.........t...................................................................p.......ht..tt.........s.h.p..............h...h..h.......p....h...s...p..p......t.......l........p...p...G..........ps...l...ll.................D...ss...................................................hp...........t..pt.p...................p...th.h.p..h......sp.......p....h..s..h.p.....................................h..h.h...l.h..h...p...s.....s.......c.h.h.h.p.R.................................h..t.t..R..stt......................................h.....h..................................................................................................................................................................................................	0	467	898	1220
+13514	PF13672	PP2C_2		Protein phosphatase 2C	Coggill P	pcc	Jackhmmer:A9C323	Family	Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.28	0.70	-11.58	0.70	-4.93	68	3942	2012-10-03 01:39:20	2010-12-15 15:10:55	1	30	2499	16	1091	5760	566	219.60	18	65.13	CHANGED	tGpoHh.ppu..tssQDsht......htth.sss...hl...l..A..VADGAGS......u..p..hSchG....uplAsp.ss.....h.ptlpphh.................sptphs...............t.pthhp...plh..pphht.......................................psttp....pt...phpchuoTLlhsl....hs.......s....s.h.......hh..hhplGDGsl.shht.........ps..uph.ph..lsp......s.c...s......GEa.s...Np...............TtFlsss....sshp.ph.......................................phhphp...h.pth...sslhlhTDGlp..........s.sl.....tstp.........sahs.hhpth...hpt...h..spst...........hppp...LtphLp	............................................................................................................................................................................................................................ht...............t..NpDthh.............t....ttt.............l......h......s.....lADGh....GG.........p..p........sGc.h.A............S...ph...u..lp..ph.........h.p.h.h..p.p.ph...............................pttt.t....................................................h.pth.hp....tht....pp.ht..............................................................................................................................pt..tt.p...........pt.....ph.p.s..h..u....T....Tlsshl........hp.....................s.........s.p..................hh..hsplGDSRs.....hhh..................cs......s..p..l.....pp......l..op.....................D..+...........s..................................h.th..s.......sp...................................tt.t.l..s.tp.........p.s.t....ph..............................................................................................c.h.t.php.....h.p.ts....-.h..l.l.L.s.SDGlp...................s.hl........sspp..............h..................................................tht.thttt..t.......................................................................................................................................................	0	376	772	985
+13515	PF13673	Acetyltransf_10		Acetyltransferase (GNAT) domain	Coggill P	pcc	Jackhmmer:A9C0U2	Domain	This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.18	0.71	-10.45	0.71	-3.97	46	6639	2012-10-02 22:59:21	2010-12-15 17:48:46	1	97	3051	5	1600	44588	6348	116.40	17	61.61	CHANGED	Dhstltplhpc.shps.p.s.h.hh.s....tth.......h..s.l.....cphhpp..s......hhhlh.hss.....pl.....s..ua.....s.t......h...p....s...ssc.......lsh.....L..hstsphptpGhupsLls.tltp.th..pp...uhp..hLpsp.......ushhu...psh.ap+.hGa	.......................................................................................................................................h......................................................h........................p...h.............p.p..h..l....t..p.....................h.h...h....l...s.....p....p...s...s..................................p.l...............l.....G.a..................h..s....................................l.........p...........t.........ptp.............................................lst...............l...aV..p..P.p.h..p..t..p..G....l....G....p....t......Ll........p....t....h.hp....t.h......tp........tht.......h.l...p.lp..............ss.......tA.........hs.F....Y.p.c.hGF............................................	0	480	972	1299
+13517	PF13675	PilJ		Type IV pili methyl-accepting chemotaxis transducer N-term	Coggill P	pcc	Jackhmmer:Q47EX4	Domain	This domain is found on many type IV pili methyl-accepting chemotaxis transducer proteins where there is also a HAMP, signature towards the C-terminus.	23.00	23.00	23.10	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.61	0.71	-3.75	504	2034	2010-12-16 09:58:11	2010-12-16 09:58:11	1	65	1235	6	420	1339	56	110.10	25	20.36	CHANGED	uh..hh...lt..ust..ssA.cAINhAG.SLRMQSY....RL...h......h.h.....st.u.....p.t..hh...p..thppsht..p.sh..tp......Lpptsst..................s.s.l.psph........tp........Lpp.pW.....pc.lp....s..tl......pp...spp..................tt...shpsh.ssp....ls	.................hhht.sst.tsA.cAINhAGSLRMQSY....RL.......s....................h.h.................st..u..........p...p...t...hh.....p..thpps..ht..p.sh...sp........Lpptsst..........................psl...psph..............tt........Lps..W....pchp....stl..........pp....spt....................httslsphlt...................................................................................................................................	1	105	246	341
+13518	PF13676	TIR_2		TIR domain	Coggill P	pcc	Jackhmmer:Q47BW0	Domain	This is a family of bacterial Toll-like receptors.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.24	0.72	-3.87	214	2056	2012-10-02 18:56:14	2010-12-17 13:44:38	1	344	944	8	1033	5257	266	109.00	18	21.07	CHANGED	lFlSYs..t...p.D..pt...hAchl...ttt...L......p....p..t....Gh...p...Va...h..s......h.ch.h...s...Gssh..hptlpps.l...p.p..uphslsll.Sssah....p.S............s..asp..p.E....hptA......tp......ts......+...llPlh.......lc...s.s........ph...ss....h.ls....plts.....hc	..................................................lFlSas.....p........p..D.........pp..........h.s.....p.....t.....l.....t.pt....L.................p...................p........t........Gh.......p..................sa......h..D..............p.sl..t............s.......G..p.s.h........tpp.......l.p...pu...l......p.p...uc.....h..hlh....l.l..S..sshh....p.s.....................p...aspp..E.....httu..................hp.............ts..........c.....llPlh........hp...s..h..........th................................................................................	0	444	754	932
+13519	PF13677	MotB_plug		Membrane MotB of proton-channel complex MotA/MotB 	Coggill P	pcc	Jackhmmer:P45443	Domain	This is the MotB member of the E.coli MotA/MotB proton-channel complex that forms the stator of the bacterial membrane flagellar motor. Key residues act as a plug to prevent premature proton flow. The plug is in the periplasm just C-terminal to the MotB TM, consisting of an amphipathic alpha helix flanked by Pro-52 and Pro-65, eg in Swiss:D3V2T1. In addition to the Pro residues, Ile-58, Tyr-61, and Phe 62 are also essential for plug function [1][2].	24.00	24.00	24.00	24.00	23.60	23.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.89	0.72	-4.65	1028	2913	2010-12-17 16:12:36	2010-12-17 16:12:36	1	5	2048	0	745	2094	570	56.70	30	19.45	CHANGED	h..hh+.+.p......t.tt.sppssuWhluYADFhThhMAFFllhahlSssstpc...........hptluphFpsshs	..................h..h++p......t.pp.stttssWhlsYADhhThhhAFF...llhahh..St.ss.p.c...............hptluphhpssh.s.......................................	0	250	484	613
+13520	PF13678	Peptidase_M85		NFkB-p65-degrading zinc protease	Rawlings N, Coggill P	pcc	Jackhmmer:B7UNX4	Family	This family of bacterial metallo-peptidases is thought to compromise the inflammatory response by degrading p65 thereby down-regulating the NF-kappaB signalling pathway [1]. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52; and the heterodimeric p65-p50 complex appears to be most abundant one.	21.80	21.80	22.50	62.20	21.30	19.20	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.66	0.70	-5.00	8	95	2011-01-11 13:03:09	2011-01-11 13:03:09	1	1	85	0	1	39	0	246.90	84	71.65	CHANGED	sppppDsYA-YVlspGpRt..pLSsspLsslh.sVp+AVppShupLlDcHTAhAIEsTlh-ALhpSpTFRcAVuFul+pc+psLGh........IpYRN.YEls-pops+hpclpplohsEIhpSsAspsPIls.h.sE.AsE--s.pcP..aVsISlAPshsStcYPhWQpuLIHEIIHHlTGAuDP..t-s..RlGPTEILApRlApELsWsI..Pp....FpuYssP-RlpAlppRsFpuLhcslhRHcpctptllpRLssIucthcASP-	............PNRAENAYADYVLDIGKRI..PLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEcVHIGC........IKYRNEYELNEESuVKIDDIQSLTCNELYEYD.VGQEPIhP.I.CE.AG.ENDN.EEP..YVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPS.GDSNIELGPTEILARRVAQELG.WSV..PD....FKGYAEPEREAHLRLRNLNALRQAAMRHE-NERAFFERLGTISDRYEASPD.....................	0	0	0	1
+13521	PF13679	Methyltransf_32	Methyltrans_27;	Methyltransferase domain	Coggill P	pcc	Jackhmmer:A9BXC4	Domain	This family appears to be a methyltransferase domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.98	0.71	-4.50	63	1223	2012-10-10 17:06:42	2011-01-12 13:55:34	1	19	861	0	577	1525	252	151.10	24	34.50	CHANGED	+Kh+QVp+....hhphlcs...llpph............tpssshsllDhGuGKuYLuFlLh..hhpt.......ssclhGl-s+sclscpupplAp+Ls..a.sphpFhphsltpsh.......................................................................................ssphcllsuLHACsTATDsAlphulp..ppu+hllhVPCCptclspp	..........................................................................................cK.cplpphhphlpt...hht.......................................p...tshpllDaGuGKGYLuhhLth......................t..hshp.lhulE...hc..p......p....l...s.p.t.u..pp..h....u....p.c.l.t.............h.......t...p..h..p...hhp.s..s...hts.h..t.......................................................................................................................................................................spthshslu.LHACss.ho.spslch..s.....l...........p.......t.........p.....s..ph..............ls.....hsPC.Cap.lp..t..............................................................................................	0	197	312	453
+13522	PF13680	DUF4152		Protein of unknown function (DUF4152)	Bateman A	agb	[1]	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in archaea. Proteins in this family are approximately 230 amino acids in length. The structure of PF2046 from pyrococcus furiosus has been solved.  It shows an RNaseH like fold that conserves critical catalytic residues [1]. This suggests that these proteins may cleave nucleic acid.	27.00	27.00	332.60	332.50	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	227	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.72	0.70	-11.53	0.70	-5.34	5	13	2012-10-03 01:22:09	2011-01-12 14:06:31	1	1	13	0	11	17	0	223.80	73	99.79	CHANGED	MRIVSADTGGAVLDEsYEPIGLIATAAVLVEKPYKTAKhSlVKYADPFNYDLSGRQAI+DElhLAIELAKKVKPDVIHLDSTLGGIElRKLDEPTIDALsISDRGKEVWKELSKDLQPLAKKFWEETGIEILAIGKSSVPVRIAEIYAGIYSAKWAIEYA+K..EG+lIIGLPRYMcVEI+-GKIhG+SLDPREGGLYGEIEsEs.EGIcWElYPNPlARRFMVFElW+E	MRIVAADTGGAlLDEsYpPIGLIATsAVLVEKPY+TAshSlVKYADPFNYDLSGRQAIRDEshLAlELA++VKPDVIHLDSTLGGIEVRKLDEPTIDALsISDRGKEVWKELSKDLQPLAKKFWEETGIEIlAIGKSSVPVRIAEIYAGIYSAKWAIEYA+c..cG+llVGLPRYMcVEI+sG+IhGcSLDPREGGLYGEIEs-s.-GItWElYPNPlsRRFMVhEVat....	0	1	1	6
+13523	PF13681	PilX		Type IV pilus assembly protein PilX C-term	Coggill P	pcc	Jackhmmer:A9BNC4	Domain	This family is likely to be the C-terminal region of type IV pilus assembly PilX or PilW proteins.	25.60	25.60	25.80	25.60	24.10	25.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.52	0.72	-3.52	20	47	2011-01-12 14:33:16	2011-01-12 14:33:16	1	2	40	0	20	47	9	97.10	25	40.70	CHANGED	sssth..Psp.tc...suhhhushsp......s..pssppGlCt....tsst........pshWsssc...ts....sshp.s..ps..........s.ssspaGpaT.Gsh......ss.usshlttpts....spssRYhIEhlshts	.........................s....hP....p....ushhushts......shssphppGLCtp...tsst..........pshWssss...hp........ssst.....s.........pstsstYGpFT.Gst......ss.usshL....s......sptsRYhIEhls.p.p....	0	1	13	18
+13524	PF13682	CZB	MCPsignal_assoc;	Chemoreceptor zinc-binding domain	Coggill P	pcc	Jackhmmer:Q47EQ8	Domain	The chemoreceptor zinc-binding domain (CZB) is found in bacterial signal transduction proteins - most frequently receptors involved in chemotaxis and motility, but also in c-di-GMP signalling and nitrate/nitrite-sensing. Originally discovered in the cytoplasmic chemoreceptor TlpD from Helicobacter pylori, it is often found C-terminal to the MCPsignal domain in cytoplasmic chemoreceptor proteins. The CZB domain contains a core sequence motif, Hxx[WFYL]x21-28Cx[LFMVI]Gx[WFLVI]x18-27HxxxH. The highly-conserved H-C-H-H residues of this motif are believed to coordinate zinc; mutating the latter two histidines of the motif to alanines abolishes Zn binding. This domain binds zinc with high affinity, with a Kd in the femtomolar range. Although the function of the CZB domain is not yet known, scientists have speculated that it may function as either an unknown signal input domain, based on its frequent association with signalling output domains, or as a domain that helps to stabilise protein tertiary or quaternary structure.	20.00	20.00	20.20	20.20	19.60	19.50	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.55	0.72	-3.80	345	1282	2011-01-13 13:31:52	2011-01-13 13:31:52	1	83	938	0	334	896	70	71.70	26	17.09	CHANGED	c.h...-Hhhahppl.hph.lh........ttp..p.pht.scppC.phG+Wa.puts......ppthsph....ss........a.pplcpsHpplHptupphhpt	.........................h.sHhhWhhph.ach.lh............sp...phpp.tsaspC..phG+Wh.pshu....tpphsph......st.............a.ctl.-.ssHpclHpsupphh..h..............	0	135	281	309
+13525	PF13683	rve_3		Integrase core domain	Coggill P	pcc	Jackhmmer:A9BZ80	Domain	\N	26.50	26.50	26.50	26.50	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.14	0.72	-4.45	121	4386	2012-10-03 01:22:09	2011-01-13 14:25:37	1	37	1527	0	913	15372	2196	62.80	30	37.29	CHANGED	tulphphhpPGcPhpNualEpFNsph+cEhLstph......h.slscscthlppWhp.cYNppRPHouLGhhTP	......................................tlt.ph.hpsGp..Php......Nu.hhEpast.....ph+.............s.E...h...lstph...................atsh..tc..scp.t.l.tpah........p.hY.Npp...R..PH..p..u..L.shhsP...............................	0	204	552	722
+13526	PF13684	Dak1_2		Dihydroxyacetone kinase family	Coggill P	pcc	Jackhmmer:C9LMG3	Domain	This is the kinase domain of the dihydroxyacetone kinase family.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.68	0.70	-5.49	228	1830	2012-10-02 12:41:15	2011-01-13 14:44:36	1	7	1719	0	319	1574	117	297.40	38	56.58	CHANGED	caGYCTEallphppt.............ch..cph+shLpsl.GD.SllVV..sD-c.............llKVHVHTpcPGpllphuhpa.GpLhclKI-NM+tQ+pphh.................t........................tttp.pp.......ch...ulluVus...GcGl.sclF.cslGsshllpGGQT....MNPSTp...DllpAIcps.sAcplhlLPNNpNIlhAApQAspls...cp....p.lhVlPT+olsQGluAl.lsassst.sh--Nhp.sMp-uhsp........V+oGplThA.VRDTpls...GhcI+cGDhlGl.........h-scIhss...sp-..hhpsshpllcph..ls--u.EllTlhhG.p-sscc.pucp........ltptlccp......a..s.-lEl-lapGsQPlY.alloV.E	....................................................................aGYCTEhhVphpps..........pta-h-cFRs.h.Lspl.....GD.SLLVV.....sD--..............llKVHVHT..-cPGp...V..hphG.pa...GpLhKlKl-NMRp.QHcthl................p.p...........................................................................tptttt.pt.ppt..ph.........ulluVss.......GcGl..s-lF.cuhGsshl.IpGGQT...............MNPSTE........Dll.cA...lcp..s.....sA...c...p.lllL..PN..N.pNIhMA...A...pp...A...A...p..ls........-t.........shVl.o+..o.......lsQ...Gho.....Al.h.....s.....a.....ssst.....sl-.-N..tt.pMspulss.................VtoGplThA.VRD.Tp.l-.....GlcI+csDhlGh...............l-scIlss......ssD......hhpsspphlpcM.........ls-..D....o...E.......I..l..T...lh.hG...cD.uspp...s..p.p........ltph.lpcp.........a......DlElElapGsQPl.Y.YlhSVE..............................................................................................	0	127	230	286
+13527	PF13685	Fe-ADH_2		Iron-containing alcohol dehydrogenase	Coggill P	pcc	Jackhmmer:A0Z2K3	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.73	0.70	-5.07	57	650	2012-10-02 14:41:14	2011-01-13 16:02:49	1	3	514	4	210	15098	4240	260.30	33	66.02	CHANGED	hlupuslsclsphlpch...t.h..p......clhllsDps...ohph...hucpltpsLpptsl...ps.t...hh.........p....s....s......hpsltc...lhpth....t....p....c..s-.....hll.ulGuGpl.DlsKahua...hshPalsVsTAsShDGauSssASlhhp..GhKhoh...AthPhullsDhsllppAPtchltuGhGDlluKhT...A.l...t........DWp..hu.c........th......sc..........l.........sptshp.hl.psh..pps...h.t.....s....p.....c......phl.....ptLhpu....L......s.hu...sluh......S..+PA.....SGuEHhlSHhh......-hh.......h......s.......h.h......HG.pVG	.......................................................................hGpsslp.c.h..u.p.l...lp.ch.....t..h...p.........psl...l..l...s..s..ps.......T.h.tl............s.......G...c....p..l..p..s...s...L..c....s....s....s...h.....ps.h........................ss.p........s..................s..........................h.s.sl.t...p....lt.c.p.h........p....s......h......c.sc...........hllulG.u...Gp.l.D.l..s..K..................h..................A....................u....................h.......................c....................h..................s....................h...................s...................a..................l......s..................Vs.T..............A......A......S....h....D.G...a...sS...s....s...........A...s..lp.t......t.......G...h...K..t.oh..t....s........t.sP...u...l.....lsD.lc.l.....l.....s.s.A......P.p.c.h...h.s.u.GhG..D....ll.......u....K..l..s....A..l....t......................DWh....lAc.....................ch.....sE...........s.l..............s.p.h..s...h...p....h...l...p...s...s...l........cs..s...lp............c..s.c..............c........psh.......csL..h.-u.L................lhS...GlAMth............hssS.RPA.............S...G......u.EH.h.h...SH...hh....-hh...........t.....s.s....hhHGtpVG...................................................................................................................................................................................	0	75	145	176
+13528	PF13686	DrsE_2		DsrE/DsrF/DrsH-like family	Coggill P	pcc	Jackhmer:A5EWY2	Family	DsrE is a small soluble protein involved in intracellular sulfur  reduction [1]. The family also includes YrkE proteins.	25.00	25.00	25.10	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.97	0.71	-4.42	32	864	2012-10-01 20:53:36	2011-01-13 16:37:43	1	15	675	10	260	763	82	149.10	38	44.23	CHANGED	pp++hhllhossh.c..hAhAuaIlAsuAAAhGh-VThFFTFWGLslL++sc.phpl........cpshltphhhhhh..t......hsh.shsGhusthhpthM..............................................Kc+sssoLp-LlchAh-pGV+hlACpMoMDlhGhccEELlDGl.phuGsAsaLpcAt-uslsLF	.........................................................t..p+ssIlhhuG..phD..KAhAuhIlANGAs.AhGp-VTlFFTFWGL.NsL+Kt..p.p.sp.l....c.Kp.hh.t+hFshMhstts.p.....................h.lS+MNhhG.hG.stMh+.tlM...........................+++sls.o.L.pLlc.pAh...-...p...G.lKllACpMoM.DlhGlp.cE.E.L..hD..tV..-huGVusYl.sc.AppushsLF..............................	0	105	187	233
+13529	PF13687	DUF4153		Domain of unknown function (DUF4153)	Coggill P	pcc	Jackhmmer:C9LQV3	Family	Members of this family are annotated as putative inner membrane proteins.	25.00	25.00	25.40	25.30	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.90	0.70	-4.82	46	732	2012-10-01 23:40:40	2011-01-13 16:41:44	1	2	721	0	91	498	28	233.20	38	42.73	CHANGED	lhhGls.lh....lh.ulshLF.hsl......st.pha....h.plh......hhshhhhusshaLuhls....p..p.....p......c...htps..........pt..h.....ph.llpalllPLhhlYshlLah.Yhh+IllshplP.....pGhlu.......hl.lhhh....hh.shlll..hhhhh....p.ppp......+.a.....hpha....h+hhs...hlllPll.l.lhhhuIhhRlspYGlT.sR....halllhslah.hshhlhhhh......p+.pt........p.h.........ls.hsh.sllh.llsshsP.hsshslotpSQhsRlcph	.............................................................................................................lhsGLhWLV....LLLWupLF.......+...LV.........GI.pFF.....s.TLFht........schFhalol..G..Ll..o..ALAV..lL...........u.R....ppp.....h...lcuh.....................p+.L.......ho.LIAsG..LLPLVoL.LsLhFI...h.sLPh.s.G.L.u.u.lu.....c+loA...........As..LLhs.....Lu..h.l.Ll.lhAIV...........p-sp............K.s.......lshh....lRsLh......LlVAPla....l..lAuWALWlRl....uQYGWTsDR....Lhllllhlh..Lsahluhlh............R+.up.........ssh.h.......tthh.lss.L.sLVl.LlLLsSPlLDshRISVNSphARapu.u.............................................	0	35	63	76
+13530	PF13688	Reprolysin_5	Peptidase_M84;	Metallo-peptidase family M12	Coggill P	pcc	Rawlings N	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.66	0.71	-4.38	48	463	2012-10-03 04:41:15	2011-01-13 16:50:21	1	31	230	47	275	3504	182	203.10	22	28.71	CHANGED	ss+plsLl.lssDssasssa..u...s.................spptllshls....sAsslappsh.................s..Is....lsLp...slslsspsssss..................t.sssssshLsph........................sshc...uppps.shuahhhhsssss...u...hGlAal........Gphs............ssss.....sssss...ts...........................hhhtsssp...hplhAHEhGHsaGAsH....Dsssp............tsts.Cshst...............ssss.GpaIMsss.ss........sshsp..FS	....................................................................................................................t..pps.lh.lssD.p....p..ah.pth..ss...c...............................tshphlhp..hls.......................ps.tslh.psh...........................s..ls....htlp..............plp.l.h..s..p..s..s..sp..t..........................................ttss.h.s.sp.phL.p..F..................................................s.p.hp.........t.t.....s.....p..s.....s.l.....u...ah.h........o.h.....p.....s...h...ss............G..............lGLAal.................Gssp...................s.sst.......uuhss.....pt.................................................hs..hh.h..o...tp.s....t.hlhA......HE..lG...........H..saGu.H......Dsss.................................p..Cs..........................ts.ts..upalM.shss.........s.t.FS..............................................................	0	114	164	230
+13531	PF13689	DUF4154		Domain of unknown function (DUF4154)	Coggill P	pcc	Jackhmmer:Q47CB5	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 172 and 207 amino acids in length. Many members are annotated as valyl-tRNA synthetase but this could not be confirmed.	24.90	24.90	25.10	25.80	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.64	0.71	-4.59	103	788	2011-01-14 11:37:18	2011-01-14 11:37:18	1	6	728	0	143	407	62	141.30	44	76.62	CHANGED	pct..........pl.c.......Ashlhshhpasc.WP.....ss......s...ss..lp...lClhu.sst..hs.........s.s.Lp...p.h.tspph..ss...c.lpl...........ppl........s..ssst......h..ss........Ccllalupt.p........ttphtplhp.tlpspslLolu-tss.sptGu....hlsLhh.pss+lpFclNlsssp+uGlplsu.plLpLA+p	........................p.....VphhVsGIlSYT+..WPuh......uuP..s+...LCIhu...suc..au.........s.s.Lp...ct.Aspsh..sh...hPlhl...........+s.........p..ptsh......h...us........CsuhYFGsc.o........P.shQh....-Lsc.pas.u+u...LLlIAEp.Ns....EChlGS.........AFCLll.......pNscV+FsVNLDuLoRSGV+VsP.cVLhLARp.....	0	35	89	118
+13532	PF13690	CheX		Chemotaxis phosphatase CheX	Coggill P	pcc	Jackhmmer:A5EYB3	Domain	CheX is very closely related to the CheC chemotaxis phosphatase, but it dimerises in a different way, via a continuous beta sheet between the subunits. CheC and CheX both dephosphorylate CheY, although CheC requires binding of CheD to achieve the activity of CheX. The ability of bacteria to modulate their swimming behaviour in the presence of external chemicals (nutrients and repellents) is one of the most rudimentary behavioural responses known, but the the individual components are very sensitively tuned [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-10.07	0.72	-4.13	95	880	2012-10-01 19:50:22	2011-01-14 15:54:09	1	12	643	7	333	939	49	97.90	23	51.70	CHANGED	lsu.hluh...sGsh..pGhlhlshspphshpl......s...p.t...l...G....-c....t...ps....pc..pltDslGElsNhIsGss+......sch........uh.....p....hpl.slPpllpGps.htl..phs.............ss.sp.tlslsap	...................sslIGh...sGsh..cGphhlshscphAhcl......s....p.t....h.......G.....pc.........pp.....hs-.s.pssluElsNhlsGssp....shLt.......uh.......s.hcl.usPtlltGps.hpl..p...............t............................................	0	161	258	292
+13533	PF13691	Lactamase_B_4		tRNase Z endonuclease	Wood V, Coggill P	pcc	manual	Domain	This is family of tRNase Z enzymes, that are closely related structurally to the Lactamase_B family members. tRNase Z is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Swiss:Q10155, is targeted to the nucleus and has an SV40 nuclear localisation signal at its N-terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, Swiss:P87168, is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.88	0.72	-4.50	41	279	2012-10-02 15:46:01	2011-01-14 17:05:56	1	11	238	0	197	491	119	61.80	37	7.17	CHANGED	pslossTsDTst.sslhLph-.p.cRYlFGpluEGoQRshsE..p+l+l..uKlpslFLTGph.s...............................................WsshGG	...................hshsotDos...sslhla.h-..p...pR...YlF.NsuEGsQRhhpE..+.+l+l..u+......lcsIFLTths.................................................WsshGG..........................................................	0	71	115	167
+13534	PF13692	Glyco_trans_1_4		Glycosyl transferases group 1	Coggill P	pcc	Jackhmmer:D2BSD5	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-11.02	0.71	-4.01	266	5146	2012-10-03 16:42:30	2011-01-17 13:51:46	1	174	2454	8	1838	35567	12883	141.30	16	28.30	CHANGED	p..hh....hl..Gsh...s..ph....shpsh...l.lp.hh..........l..t.p.......t.......h..s....p....h..p...hhl..h..G.s..........h....s.....s............p.....l..pph........t......sl.p....h..........h..uh...h...........s..c..h.sph...hsp...s.....c..l...s..l......s...P..h.......t.....hss...........s...h.....s.....h.K.lh-hhs.sGhPl..l......s.....osh....s.....hps.h.................h..t.......t..hs...h..h.h..s..s....s......s..pshspslt.ph.hp.....s	..................................................................................................h...hhshh...s.th.....t..psh.phh..lp......h.h...............................tl.....t..p..............................p................................h....s................p.......h......p.......hhl....h..Gt..............................s..s...p.......................p......lpph......................hs........sl..p....h.....................................h..sh..l...............s.....-....h..sp.h....l.s.p.....u...........c...l...s...l.........s.....s...h...................p.........ss..............................s..h....s......h.K.lhE.hhu.sG.h..Pl...l..........s.......osh......s.........hp.s..h.........................................h..tt..........s.ts...h....hh.......s..s..........s................s....pph.hptl.phh..........................................................................	0	731	1269	1619
+13535	PF13693	HTH_35		Winged helix-turn-helix DNA-binding	Coggill P	pcc	Jackhmmer:D2BY08	Domain	\N	25.00	25.00	25.10	25.10	24.00	24.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.44	0.72	-4.19	22	1007	2012-10-04 14:01:12	2011-01-17 14:12:01	1	2	663	2	160	491	4	75.70	59	84.66	CHANGED	DWHsADIIAAL+K+GToLAAlSRpAGLSSSTLANALsRPWPKGEalIAcsLulcPuEIWPSRYaD.psGpll-RchRhR	.............DWHPADIIAuLR.K+G.TShAA.SRcsGLS.S.S.T.LANA..L..o.RP..W..PK..G..EhI..IAcALGscPh.IWPSRYaD.pspphlpRp.h....................	0	10	62	108
+13536	PF13694	Hph		Sec63/Sec62 complex-interacting family	Wood V, Coggill P	pcc	[1]	Family	This is a family of closely related Hph proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER. Cells with mutant Hph1 and Hph2 proteins revealed phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterized. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium [1].	19.90	19.90	20.60	24.00	19.10	19.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.13	0.71	-4.26	7	38	2011-01-17 14:23:41	2011-01-17 14:23:41	1	1	23	0	18	34	0	171.50	38	32.47	CHANGED	pp.pp.hh.DhsSssTGtFSDpMFpss.c....ppp.phsps.ph.pssphpspschsssttttpshstpph.spsh...spsthpphspt..pup.cspp...........t+Shupoh.shD+KRLVsQFLc.SlpsSss.pssppsst.............shpo.Sphshssuhp.p.......................hpsLhYpDLcpsstppppso	................................................................................................pLchpslPshsSspTGhFSDhhFpss.D...............hstu.Sh.cs.plSPK.....psaNsstsh.hushsptphtShsl.......apupcpth.uFpplQupppsp+............+SsusS..F..sh-+KRLVsQFLp.ShtsS.s.sohpppss.t.usshssIh.s.shps.Sphs.sppS............................pSLhYHDL-uSshpcsSs............	1	3	8	13
+13537	PF13695	zf-3CxxC		Zinc-binding domain	Coggill P	pcc	Jackhmmer:A9VEF7	Domain	This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.	22.00	22.00	22.60	22.80	21.20	21.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.27	0.72	-11.41	0.72	-3.77	45	436	2011-01-17 15:42:00	2011-01-17 15:42:00	1	13	129	0	268	393	0	92.60	29	37.05	CHANGED	phhGcFpC..ppC.spsWsSsplhlsh+hh....t.....th................hph+hacQcC+pC..sphppPhh........s.ps.......hs-Rlshchpchsshphpt.............h.t.p.t....tPHppcLCEuC+tG	............thGcF+C..spC..p+pWpSupVhsl.h.................tt.................sphh..hatQpCp.cC....pp..pPph........................p..lpclt.p.p.shpppt...h..t.h................h................tsHcpchCptCpt..................................................	0	64	89	155
+13538	PF13696	zf-CCHC_2		Zinc knuckle	Coggill P	pcc	Jackhmmer:A9VEF7	Domain	This is a zinc-binding domain of the form CxxCxxxGHxxxxC from a variety of different species.	27.00	12.00	27.00	12.00	26.90	11.90	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.86	0.72	-4.45	5	190	2012-10-03 11:39:54	2011-01-17 17:21:59	1	28	117	0	149	536	7	31.30	45	8.63	CHANGED	P+KsPPPcYLCHLCFpKG.HYIsDCPQ..AsPKuE	...............phPPssYlC+lChpcG.HaIpDCPp......sp.............	0	81	103	129
+13540	PF13698	DUF4156		Domain of unknown function (DUF4156)	Coggill P	pcc	Jackhmmer:D2BXE0	Family	The function of this family is unknown but members are annotated as putative lipoprotein outer membrane proteins.	25.00	25.00	25.10	25.40	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.00	0.72	-4.10	49	839	2011-01-18 10:31:11	2011-01-18 10:31:11	1	1	682	0	94	295	28	93.80	51	79.50	CHANGED	ssphostuppVph.sssps..sppCphLGpVoGopu.sahothhtss..sshhpGAhN-L+NcAAt.hGuNslhhhs.....................spthssssshhGpsYcC	........................S.NpLouAGpsVRl..s-ppP..GuECQLlGosTGpQS.NWhSGpaGpE..uuSMRGAANDLRNpAAA..M..GGNVlYGloSP....opsh.............................LSSFsPTsSphhGQVYKC............................................................	0	14	37	66
+13541	PF13699	DUF4157		Domain of unknown function (DUF4157)	Bateman A	agb	Jackhmmer:C7PSA5	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. This domain contains an HEXXH motif that is characteristic of many families of metallopeptidases. However, no peptidase activity has been shown for this domain.	22.00	22.00	22.10	22.30	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.67	0.72	-3.84	185	470	2012-10-03 04:41:15	2011-01-18 10:44:17	1	49	214	0	257	522	62	74.20	33	11.64	CHANGED	sLsssl+sthEsthG..tD.hosVRlHs...s......tusptspslsApAaTp.GscIhF....s.Gp.tststt..........upclLAHELsHVlQQptu.t	............................................Lstsl+sthEsthG..tD..husV..RlHss.....stusptspslsApA.aTh...GscIhF....s.Gp...ts.t..........spclLAHELsHVlQQppu.........	1	100	177	239
+13542	PF13700	DUF4158		Domain of unknown function (DUF4158)	Coggill P	pcc	Jackhmmer:A8LT43	Domain	The exact function of this domain is not clear, but it frequently occurs as an N-terminal region of transposase 3 or IS3 family of insertion elements.	25.00	25.00	25.20	25.00	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.63	0.71	-4.76	108	1440	2011-01-18 15:32:58	2011-01-18 15:32:58	1	7	737	0	250	1165	105	151.80	26	19.69	CHANGED	lLosppcppl..hslPs..s..cpclh+aaoLscpDlplIp..p.+RtspNRLGaAlQLshlRa.Ghhls....s....spplPtsllpalApQLtls...s..s.s..hppYu.p.RcpTRt-HhtcltphhGa+sFst..st..h.p.pLhpaLhphAhpsscshh.LhcthlshL+pp+llLPuhoslERllucuh	..............................Lo.tpptth..hthst..sct-L.hpaaohs-t.Dlph.Ip...p..+R.tstsRLGhAlQLshhRh.Ghhls....s....hpthsssllpal.u..p..QL.tls....s...t..p....htp.Ys..p..RppT+tcHhtplpphhsac.ast.........st..hp.plh.p.hLh.p.hAht.sscs.h..LhsthlthLhpp+lllP.uhsslpRhhups.............................	0	50	136	189
+13543	PF13701	DDE_Tnp_1_4		Transposase DDE domain group 1	Coggill P	pcc	A8LT71:jackhmmer	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	25.00	25.00	25.10	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	449	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.28	0.70	-6.31	10	2054	2012-10-03 01:22:09	2011-01-18 17:04:24	1	6	411	0	238	1429	381	279.80	36	91.76	CHANGED	FsslsG+pVhucF-GGslSSDuGllLl+plDcpltlspRhAsClcDtR+sSYlcHSlc-LluQRIYQIAsGYEDsNDuNpLR+DPhFKlALs+lPhsssst..LASpPThSRLENslspp-lp+huR.............uFVDtFL-SYt+sPc.IVLDMDsoDDtsHGpQEhAFFNuYYpssCYhPLalFEupoG+LLsApLRPGcpcoGctslshLpRllcpIRctWP-T+IllRGDuuFupPElMshCEspsssD.lFGhuGNssLhc+tsslls-sRcpctpptcpshh...ts..t................RhacpsaYsA+SWscsRRVVhKsEhtucGsNhRFllTsL......scssPpcLYcchYCsR.GpsENRIKEhKhDLtSDRTSscsFluNQLRLFlusAAYVLhpulRppsLspT..LAKApsuTIRLpLlKLAARVslotRRIllcLPouCPhpsplthshppLphtp.hs	..........................................................................................................................................................h..................................................................................................................................................................................................................................h.....lDhDso.........u.ppp..................a...h....t....sa..Ph..h..hh.................tt............hR.up......s..tt..t..h.....t..ht.h...h...t....h..........................................hRh...D.ut.....t.h.......h..............................................................................................................................................................................................................................................................................................T.sh..................t....s.s.pp.....h.....p.....h......YptR..G.p.hEN.h.IKEh...p.s.hh.....s-.......+h.s.......op..............shhtN.plRhhhsshAYsLhh...hh..p..h...h..................s.......t........p........h....t.......t.h....p....htp...hR...h...hhl+lss+hs.ps.Rp.hlphsph.h...shtt.h..h..........th.....................................................................................................................................................................................................	0	49	161	214
+13544	PF13702	Lysozyme_like		Lysozyme-like	Coggill P	pcc	Jackhmmer:B0G1S2	Domain	\N	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.01	0.71	-4.75	63	1147	2012-10-03 00:09:25	2011-01-18 18:31:40	1	9	690	0	68	686	23	158.50	43	52.92	CHANGED	lspcVlpacshVcchApchu..ls-.YlsllLAlhhpESGG...cssDlMQSSEShshs.............sNsIpDs-tSIcpGVphaspslcpApppus....-.lcsslQuYNaGsG.alsaltppG.spYoh-LAppFScphs..........upphth....sh..tt.hh..sYGshhYsppVh.pYh	....................................................tpVhsapPhVcchscE.....hslsp..hssllLAlIhsEStG...........ps.tD..V........M..Q....SSEShuhs..................................sNoIps.scpS..I+QGlphhuphLtpApc.tul.....Dl.oslQuYNaG.su.Yls..alAppG....pcaThpLAcpaS+-hs............sGpphsY.pPlul...hsGGahY.NhGNhaYsphVp.............................................................	0	16	35	47
+13545	PF13703	PepSY_TM_2		PepSY-associated TM helix	Coggill P	pcc	Jackhmmer:D2BX46	Domain	This family represents a conserved TM helix found in bacteria and archaea.	30.00	30.00	30.20	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.24	0.72	-3.81	95	2542	2012-10-01 23:59:14	2011-01-18 18:43:04	1	35	1345	0	728	2488	143	87.60	25	18.15	CHANGED	ahhplHhsLh.lsth.....hGthllulsuhhhllslloGllla..............+hh+pha...shR.tc..stcp.hhD.hHshhGlhslPFhlhlshTGlhhhht	....................................hhpLHtsLh..lsts.............Gphllslsuhhh.l.lhll.o.Glhla...h............................p.h...h...p.t.h.h...........thc....h......pp.....st.+p...hh-..hHshhGlhshhhllhhshTGlhh...s..............	0	155	412	583
+13546	PF13704	Glyco_tranf_2_4		Glycosyl transferase family 2	Coggill P	pcc	Jackhmmer:A8LQ72	Family	Members of this family of prokaryotic proteins include putative glucosyltransferases,	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.51	0.72	-3.67	164	934	2012-10-03 05:28:31	2011-01-18 18:44:27	1	33	490	0	305	3098	709	103.40	19	24.61	CHANGED	+NEshh...L.palt...a.a.p.p.l.G....h..s.c..hll..h...sN.sssDso....sphL....tp........h....sc....ls......lhp...ss..................t.sa................pp..tt.ht....h......s..........hhsh......h..hp...p..h......s.........p..s.....cW..hlhlDsDEFlshsstt...tslpsLh	............................hNpt...h.l.ta.lt.......a..a...p..t..l...s.....h....c...c.....hhl..h....ss..s...s...s.D.s..o.......scl.L....cp.......h......ss.....lp.........lhp...p..p...........................................p..th......................tt...tp..ht......h......c............hhpt.......h..hp......p...h.....t..........................t..s.....-W..llhlDsDEhlhsst.....tl....h............................................	0	101	194	240
+13547	PF13705	TRC8_N		TRC8 N-terminal domain	Bateman A	agb	Jackhmmer:Q8WU17	Domain	This region is found at the N-terminus of the TRC8 protein Swiss:Q8WU17. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain [1]. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG [2].	27.00	27.00	27.40	27.30	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	508	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.74	0.70	-5.93	13	190	2011-01-19 10:54:33	2011-01-19 10:54:33	1	7	80	0	116	183	0	433.60	38	72.60	CHANGED	lhull-VsLRVPulhllDhlhphsh.tuhs.........pp.........................................................................................hphphlthslphlGhls...........usslLhLsp++LlplYhahhuhlLhhsuahlsh.h..l..c.....-thlhls.hph.c.suhh............huhllhtl....lhssca..hhhhhshhhh.Pllhplh.lPh.s............Lhhlsshshhhoshtshhhlhpth.hshphsh.hh.....hthhplaGltuLlpshWp+LpVPslLpVFWlschshQhhs.....hhspp-ssh.....s.pphhhllhshlsssCsoshslLGhosllShlA+hluphhphaLtuh-s.cccp...hGhspuVhhhILALQTGLouLpsccRhlhLuhsLhlllTAlLp.lHpIs-PlLhuLuAS+spShpRHhRsLslChFLllhPlhlsahLhpaashshWLLhVsu.slplsl+VlsoLhhYsLFMlDuaRpp.WEKLDDhlYYV+usupslEFlhulhlhu.GAaphlFtu.....hohIpAshhhlHuYFNIWhcApsGW	....................................h..uhlpVsLRVPslhllDhlap.....h..u......................................................................................................h.hhhlth.hp.h.hGhhl...........SsllLh..Lsp..pp.......L.hphYhah.hshLLhhsuh.lsh........h..............................shal-.hu.h.phsshh................hu.lllph..............hhtht....l.lhShahh..llhclh......lPl.s...............llhhsphshhhssh.llhhhhp.hhh...shphsh.hh.....hphhcl..YGL.sLh.shWpplhhPslhhV..FWLshhshQh.hs........hhsspspsh..........shpphh.lhhs.........lhpsCsosholLGhshslS.lAhhlhhhhhhaltuhct..sc..............................hGhstuVhhhILAlQTGL.tLps.cRhhhLSh.hhlllsulLp.hhphsDPllhuLuAS+sp.Sh.h+HhRsl.lshhLhlhPshhuYhlhpaathshWLhhlhu.sl.ssLpVlsoLhlYsLFMl-tap.p...hEphDDhlYYVpuThpllEFlhulslhu.Gs.phlFtp.....hohhtuhhhhlHuYaNl...aLpAp.GW...............	0	31	40	78
+13548	PF13706	PepSY_TM_3		PepSY-associated TM helix	Coggill P	pcc	Jackhmmer:D2BX46	Domain	This family represents a conserved TM helix found in bacteria and archaea.	29.10	29.10	29.10	29.10	29.00	29.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.77	0.72	-4.54	99	885	2012-10-01 23:59:14	2011-01-19 14:09:45	1	19	462	0	319	1056	191	36.90	30	8.04	CHANGED	pphhhhlHpWhGlhhuhllhlhFhoGslhha.....ps..p..lsp	......p.hhhlHpWhGLlhuhlLhlhhloGslhha.....cp-ls..........	0	65	174	255
+13549	PF13707	RloB		RloB-like protein	Bateman A	agb	Jackhmmer:C7PC62	Domain	This family includes the RloB protein that is found within a bacterial restriction modification operon.  This family includes the AbiLii protein that is found as part of a plasmid encoded phage abortive infection mechanism [1]. Deletion within abiLii abolished the phage resistance. The family includes some proteins annotated as CRISPR Csm2 proteins.	27.00	27.00	27.00	27.80	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.54	0.71	-4.63	120	422	2011-01-19 14:48:00	2011-01-19 14:48:00	1	2	358	0	96	390	16	178.60	20	87.08	CHANGED	hlIlsEG.p...TE.pYFctl..................t.hthpphplplhstt...............................ssstpllcpstchtp........................................................................tpphDplasVhDt.D.........t.ptpphp.cshpt........scpp............thplhhSNs.sFElWlLLHapths............thsppthtt...ph..pth.........ssYpKsp.................hthhhpphts...AlppAcpltppt.tppt....................ss.sTslh..pLlctlt	...................................hhIhsEG..p...TE..tYFptl..................p.hhhsp..hpl..phhstt........................................psstpllctshphhp....................................................................................................tph.cpl..ahVhDt.D..................ptpphp...p...shph...........scpp....................phphhhSN...sFEhWhLLHFpthst.............................t..ppphhtph.....hpthh.....................tpYpKsp...............thhp.hhpphtp..........AlppApphhtp...pp.t.....................ss.hopl....pllc.l.h............................................................	0	48	80	92
+13550	PF13708	Methyltransf_27		Methyltransferase domain	Coggill P	pcc	Jackhmmer:Q3IV21	Domain	This family contains methyltransferase domains.	25.00	25.00	25.10	25.60	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-10.97	0.71	-4.77	34	854	2012-10-10 17:06:42	2011-01-19 15:25:22	1	11	411	0	44	544	11	171.00	53	64.67	CHANGED	thp+slDpphWccLhpcoGhhshMsupt+cpWpcplp..ts...........shPshotcNIhuTFppLhts+pchFp+GllslF+pL..........ShcaKTN..pshtFG+KlIl..ssllp.....hp.ph...uhs.......hshu...pps.pLsDLt+hhtllcG...KPhs-..pRpshs.tthtpthptss..t.............................................t.pshEsphFpl+hFpp.GosHlpF..p+s-Ll-+lNpllAcaYP.ssL	........................................................................s.ITRslDRcIW+cLMpcoG.MholMsupsRDpWh+sLE...D....................shPEISEsNILSTFcQLHpNKs-VFERGVINVF+uL...............................SWs.....YK...TN......sPC......+F...G.....p.KI.....Il..NNLVc......Ws.+W.....Ghp.......L.sG....ptD.pLsDLERMLaLh....sG...KPlPD...NRpsIs...lc.Ls-alpssp....s..........................................................p..ppaEDEh...FpIRYFpK.GouHITF..++.-..Ll-+lNDIIA+aaPshL...................	0	7	15	25
+13551	PF13709	DUF4159		Domain of unknown function (DUF4159)	Coggill P	pcc	Jackhmmer:C6VZA7	Family	Members of this family are hypothetical proteins. TM prediction shows them to have two transmembrane regions, with a cytosolic region of about 25 amino acids between the two, and an N-terminus outside the membrane.	25.00	25.00	26.80	26.30	24.00	22.80	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.25	0.70	-11.58	0.70	-5.21	124	420	2011-01-19 15:53:05	2011-01-19 15:53:05	1	9	358	0	171	402	276	209.10	30	33.09	CHANGED	hplAhl...ho...............G-hpsD...........suLpsLsphl...........sppTslcss..t..hsVclss.s-Lh..haPhlYhsspssh.h........ospt..hspLcpYlpsGGhlhhDsp............t.tsshstsh........pc.hphlhs...ssLp.lPs-Hslh+sF...Yhl..........hsutshhh-ttst...................h.hthhsDG....hhsllhsss.DhusuWshspps.pshhshsss..............................AhRhGlNllhYsL	...............................................plAhl..hs..................GchssD..........psuLpsLsphL...........tp+Tulcsu....p...hsV-hsp...D-Lt...haPhlYhshssss..h..........SspthsplcsYh.pp.GGhllhDsp........c.......t.tushstsh..............pchhphlhs....hssLcslPs-HsLh+sF...alh........-.hP....uphputshWsEstst........................sh.hth.sDG....hssllloss.Dhus.AWuhctpssshhsssss.....p+.........................hAhRhGVNIVhYsL..........................................................................................................................	0	72	126	147
+13552	PF13710	ACT_5		ACT domain	Coggill P	pcc	Jackhmmer:D2BYU0	Domain	ACT domains bind to amino acids and regulate associated enzyme domains. These ACT domains are found at the C-terminus of the RelA protein.	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.88	0.72	-4.16	79	4946	2012-10-02 00:29:19	2011-01-19 17:24:13	1	10	3420	7	1010	2625	1922	62.70	40	43.40	CHANGED	ppstsLpRllpllR+RGFplsshshpt...tssst....hplplsVpu.pRslch...LspQLsKLhDVhpl	.........NcsGsLsRVsGLFu+RGaNI-S.lsVus..oc-ssl.................SRls..l..s..s..s..u.p.-.p.s.l.EQ......lh+QLpKLlDVl+V.................	0	289	629	835
+13553	PF13711	DUF4160		Domain of unknown function (DUF4160)	Coggill P	pcc	Jackhmmer:C6W4D5	Family	\N	23.00	23.00	23.60	24.30	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.29	0.72	-4.12	168	574	2011-01-19 17:56:36	2011-01-19 17:56:36	1	4	384	0	179	516	65	63.30	28	72.08	CHANGED	Glhlhhah...ppHpPPHlHsphuc....tpAhhslps......hph.hpG..phsp+.pl+hlhpalphapccLh..ppWp	...................Ghhlhhah...p.p.H.pPPHlHsp.hus......hcuhhtlps.........hph...hcG...h..ss+..ph+hlhtaht...+pcpLh..ttWp..............	0	63	119	156
+13554	PF13712	Glyco_tranf_2_5		Glycosyltransferase like family	Coggill P	pcc	Jackhmmer:C6VYA4	Family	Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.48	0.70	-5.10	121	312	2012-10-03 05:28:31	2011-01-20 09:28:06	1	21	211	4	52	1116	294	202.30	38	68.24	CHANGED	ILhVsClNs-cl...acQ.Cp+.pIcsL..hVPP..GYlVQlhPIRsA.cSMsSAYNcAlSaPAKYK....VYIHQDsallN...cshhhsLlsLFp-s..E+LGlIGluGAQalPsNGlWWE..GKslV..GK.VIpYpp..psYphhp.hpphh.Y....t.spsFhsVpAIDGLlMATQYDIP........WREDLFpGFHFYDVSQSLEFp+.A.GY...hs...sQ...t...s...h...W...CIHYsu.Dp.h-.s.shhc.ph+p.FVE.+Y	...................................................................h.hlhs.pppth...htp..h.....l.ph....hs.s..sh.....hlph.hs.lR.s.........A..pSMsSuY.Np...Alsp..A...+aK......VYlHQDsallN......pshh...hsLlplF.p.c.p.....-cL.G.....h..I............G..........h.....s.....Gu.p..h...l.P...s..s.....G....l.....Wh.-........up.s...hs........GK.........Vlt..Y....t.p.....h..........a...h..t.....p..phh............tsp...sahsV.psI..D...G.LlMA.TQ.YDls................W.REDLF...pG..F.H.....F.Y..D..VSQShEFp+.A.GY...pl......sp....t.s....h..W.C.I.H......a......st.....-t.......t......s...s........a..c..ht+h.FlccY........................................	0	10	37	46
+13555	PF13713	BRX_N		Transcription factor BRX N-terminal domain	Coggill P	pcc	Jackhmmer:Q17TI5	Domain	The BREVIS RADIX (BRX) domain was characterised as being a transcription factor in plants regulating the extent of cell proliferation and elongation in the growth zone of the root [1,2].  BRX is rate limiting for auxin-responsive gene-expression by mediating cross-talk with the brassino-steroid pathway.  BRX has a ubiquitous, although quantitatively variable role in modulating the growth rate in both the root and the shoot [3]. This family features a short region, also alpha-helical, N-terminal to the repeated alpha-helices of family BRX, Pfam:PF08381 [1]. BRX is expressed in the vasculature and is rate-limiting for transcriptional auxin action [4].	24.50	24.50	24.50	26.70	24.40	23.50	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.55	0.72	-7.72	0.72	-4.50	53	188	2011-01-20 14:44:40	2011-01-20 14:44:40	1	21	25	0	128	193	0	38.00	41	4.56	CHANGED	s-Euu.+scuAK.-sIKSLTuQLK-MAc+l...s.uuhc....pscsss	.........-EuuKs+AAK.ElIKSLTuQLK-MAc+l...s.Guhc...p.t...t..........	0	16	77	103
+13556	PF13714	PEP_mutase		Phosphoenolpyruvate phosphomutase	Bateman A	agb	Jackhmmer:A1B6C5	Domain	This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein Swiss:O86937 has been characterised as catalysing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr) [1]. This enzyme has a TIM barrel fold.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	238	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.66	0.70	-5.15	124	2953	2012-10-10 15:06:27	2011-01-20 17:46:56	1	17	1973	94	941	4275	3390	240.70	35	79.80	CHANGED	F+p.LH...pts.p....sl........................................lLsNsWDusSAclltps........G...........apA.luToShulAtuh.GhsDu.........ptlshsph...l.stlppIsps.s.s................lPl..osDhEsGY.....upp....spplscs...lcclhpsGssGlslEDp.........t.......tttlh.sh...........pptst+lpAs+puststs...hhlsARsDsalht............tsstls.......-slcRupAYtc.AGADslFlsGh.....pc..sp.l.tplspth.s.......hP..lNlhs.h..st.t....hshscLtplG.VpRlShGsthhcsA....hssh.tpsspplh	....................................................................................................hRt.Lt...pp....p....sl.lsusasuh..sAhlspps.........G.....................apA..la.h.SG.uu.l.A.....A.....S.....h......G.....l......P..Dl.........G.lsohs-l...l.ps...s..ccI..scs..s...s................................lP.l..lV.Dh.....D..sG.a...Gs...........s.h.N.luRT...V+p.h.h.c.A....G.sA.u.lpIEDQh......................K+CG.....+...ssKtll..st..........................-..E.hl.s.+I.+AAh-A+.......scss............alIhARTDAhh.................................scGl-s..AIcR.Ap...AY.......s....-.AGAD.hlF.s-uh............psh..pp..h...cphscsl.p..........sP...lh..ssh..p.....ut.o...............hosc-LtphG.lshllashus.hRAh.pAhppshpt..h......................................................................................................................................	0	228	531	766
+13557	PF13715	DUF4480	Cna_B_2;	Domain of unknown function (DUF4480)	Coggill P, Eberhardt R	pcc	Jackhmmer:A6L3W4	Repeat	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with Pfam:PF07715 and Pfam:PF00593. There is a single completely conserved residue G that may be functionally important.	32.20	32.20	32.20	32.20	32.10	32.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.88	0.72	-3.93	100	11370	2012-10-02 19:08:27	2011-01-21 13:39:15	1	110	309	0	3174	13036	3876	84.30	31	8.98	CHANGED	plpGtVh...sp...p.s...ps...ls....usslhhp...ss.p......ps......sh.Tst......sGpFplp....sp.....t.ss...pLhh..sh..hGaps...hp.h.lp....tp.t...p........l.s.lh...L.pp.ssp...p..Lc.E..Vll	..............................lpGpVh....Dp....p...s.......p.P...l.....GAo..Vhlc......Go.s..................pG........sl...T..Dh...................cG..pFslp....ls.......s...s.s......t..Lh..h...Sa..l..G..Yps.....pp...l.p...l.s.......t...........s.....................l..s.lt...L...pp...c.s.p.....t...Lc.E.VVV..............................................	0	1390	2842	3163
+13558	PF13716	CRAL_TRIO_2		Divergent CRAL/TRIO domain	Bateman A	agb	Jackhmmer:P32525	Domain	This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues [1].	21.80	21.80	21.80	21.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-11.05	0.71	-4.30	101	1520	2012-10-02 01:12:42	2011-01-21 18:21:51	1	65	240	9	821	2870	21	140.20	22	13.59	CHANGED	hth.h.tup.sppGpsllhhs.uphh..............................................shcpllhYlhpph.pp.....sps..asllh.pssh.................................sp.shshlpph..............................................hphlstt..........................htpp.lptlal.l+ss.....hhh+phht.............................shhphh.stth.ttc...............................................................lhh.................lsslspL.....hphlc....hspL..pls...........tshpa-pp	.........................................................................................................hh......tG..sp..u.ps.lls.as..sp.h......................sttp...............shcpl..h..h.....Yl..h...p....h...h.c.................h.s.tps.........ahll.h..pp.th.................................s..p........h...s....h...l+ph.....................................................................................h..p.hlspp...............................hhpN..L+........s.lhl..l+Ps...............hah+ph..h...............................hhhp.hh...ss..ch..thK.....................................................................................l.h..h.................................l...s.....o...l...p...c..L.....tphls.....hpQl..cls......tshpast.......................................................................................................................................................................................................................................................	0	213	322	549
+13559	PF13717	zinc_ribbon_4		zinc-ribbon domain	Coggill P	pcc	Jackhmmer:Q5HCD9	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, Pfam:PF12773.	27.20	27.20	27.20	27.20	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-7.89	0.72	-4.26	74	110	2012-10-03 10:42:43	2011-01-24 12:58:18	1	21	79	0	72	614	889	35.80	31	8.64	CHANGED	MplpCspCpspapls-pp.ls.spGt.pl+CspCpphah	......MplpCspCpspapls-cp.ls.sput..plcCspCtpha.....	0	40	57	69
+13560	PF13718	GNAT_acetyltr_2		GNAT acetyltransferase 2	Coggill P, Eberhardt R	re3	Jackhmmer:P76526	Family	This domain has N-acetyltransferase activity [1,2]. It has a GCN5-related N-acetyltransferase (GNAT) fold [2].	24.60	24.60	24.60	26.20	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.27	0.71	-4.99	88	1293	2012-10-02 22:59:21	2011-01-24 13:23:31	1	20	1187	2	418	1028	31	180.60	42	24.00	CHANGED	chhuLhVuuHY+sSPNDLphlhDAPupplalLh..........................................s.ss............cllssl.lshEGpls.pc...hs.ppshpttpRspGcLlPhslupphtcppFupLsGhRlVRIAscPshpp.........hGhGochlph..lppa..hp..............................................................p..plDalGsSFGhTspLh+FWp+.sGFtsValppstsphoGE+oslhl+s.....Ls	...............................latLLsuAHY+TSP.DLpthhDAPup+hhhht..........................................sts.................clhGsl.......hl.s.cEG.s...LS....pp...ls.pslh.u.G....hR.............RP+GsLlspoLutphsss.tAA.sLpGtRlsRIAVHPshQc.........pGhGpplltthhphh..........................................................................................................................................................................p..plDYLuVSFGh..Ts-Lh+FWp+.sGFl.V+husp+.-suSGpYoshhLhPl.s...........................	0	131	221	337
+13561	PF13719	zinc_ribbon_5		zinc-ribbon domain	Coggill P	pcc	Jackhmmer:Q5FCF8	Domain	This family consists of a single zinc ribbon domain, ie half of a pair as in family DZR, Pfam:PF12773.	27.60	27.60	27.60	27.70	27.50	27.50	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-7.94	0.72	-4.37	79	534	2012-10-03 10:42:43	2011-01-24 14:21:25	1	21	487	0	215	626	893	36.50	35	10.00	CHANGED	MplpCspCpspapls-pp.ls.sput.pl+CspCppsahh	........hpCPpCpTpaclsssp.ls.hpst..tVRCupCpplFp......	0	55	128	174
+13562	PF13720	Acetyltransf_11		Udp N-acetylglucosamine O-acyltransferase; Domain 2	Coggill P	pcc	Jackhmmer:C5B7S0	Domain	This is domain 2, or the C-terminal domain, of Udp N-acetylglucosamine O-acyltransferase.  This enzyme is a zinc-dependent enzyme that catalyses the deacetylation of UDP-3-O-((R)-3-hydroxymyristoyl)-N-acetylglucosamine to form UDP-3-O-(R-hydroxymyristoyl)glucosamine and acetate.	24.50	24.50	24.70	24.60	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.68	0.72	-3.76	349	2605	2011-01-24 16:19:52	2011-01-24 16:19:52	1	15	2381	24	620	1760	1696	83.10	37	31.62	CHANGED	DVPPashssG.s..Ap..htGlNhlGL.+R+GFop..-..plp.tl+pAY+lla+.sG.h.....slp-Al.ppl.pp....hsp.......sscl.ppll...cFl...t..sop.......RGlh+	...DVPPYslAp....G....N...cA..p...hGlNl.GL.+..R.RG...Foc......-....plpsl+pAY+hlY+....sG..h......slc-.sh..t...cl.tc....spp...........pspV..pthh....-Fl.....p.....pSp.....RGllR....................................................	0	196	396	518
+13563	PF13721	SecD-TM1		SecD export protein N-terminal TM region	Coggill P	pcc	Jackhmmer:D2BRP0	Family	This domain appears to be the fist transmembrane region of the SecD export protein. SecD is directly involved in protein secretion and important for the release of proteins that have been translocated across the cytoplasmic membrane.	25.00	25.00	25.00	27.50	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.13	0.72	-3.75	100	2015	2011-01-24 16:50:55	2011-01-24 16:50:55	1	5	1305	0	300	1070	399	98.20	35	20.67	CHANGED	lN+YPLWKYLl..llhllhlGhlYALPNLYGEDPAVQIou.p.p.u.s..p..s..s..s..t..s...pV.pssLcpssIsh..c..ult.l.-s....s..s..lLl.Rhsss-sQLpA+-h....lppsL.....G.c.....sYlVAL	....................W..h..h..l.l.h.sl.llulLYA..l.PNl..aG--PAlQIousp.p.G.s..s...h..s..-..t...s......pVpctLpppsIsh..K....Sls..h..cs...........s..slLl.RF..c..so..DpQ.lpA+-sLppsL.....s.c.....pYlVAL...........	0	49	131	219
+13564	PF13722	DUF4161		C-terminal domain on CstA (DUF4161)	Coggill P	pcc	Jackhmmer:C5BCA0	Domain	This domain is found at the C=terminal of most known CstA domain-containing proteins. The function is not known.	23.00	23.00	23.20	23.20	22.00	22.20	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.76	0.71	-3.83	141	3040	2011-01-24 17:03:47	2011-01-24 17:03:47	1	5	2329	0	528	2010	121	127.00	41	20.10	CHANGED	Ghs...huhhapFAlhatAlFlLTolDuuTRluRahlQ-hhu.......h......htppphh.ssthluoslslshhGhllhtG.............shsslWPLFGhuNQlLAulALhlsosh.Lh+ht+t..p.....asa.lshlPhsahhlsThsA	...............hh....huFWYHFAILFEALFILTulDAGTRuuRFMlQDlLG........sh.............ht..c.s.csl....suslluTshsVs.hWGalLapGshD...........PhGGlsoLWPLFGluNQhLAulALhlsoVlLhKhp+p....p................ahW..VsllP.ssalllsThsA.....................	0	173	322	436
+13565	PF13723	Ketoacyl-synt_2		Beta-ketoacyl synthase, N-terminal domain	Coggill P	pcc	Jackhmmer:D2C0A5	Domain	\N	25.00	25.00	25.90	25.10	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.44	0.70	-5.08	53	581	2012-10-02 12:25:54	2011-01-25 13:01:22	1	2	555	0	160	516	37	202.70	26	79.93	CHANGED	Wp.p.Wup.ss.tth..ss......s.sstPtlstlPsMpRRRhSpho+lulcsuhplh......pt..pss..hlVFuSRHGElpRohsLLpslhsppslSPTuFuhSVHNsuuGhaoIhsppshssTSlAAGp-ohppullEAhuhLp.p.u.sppVLlVshDpPlPphYpsa.s........ppts.hsaAluLlLssGss.hphs..................hpss..ssss..pps.......shs.puL..phlctllssp.....s.ph.shsu.ppppWpWp	................................................................................hsth.s.lP.sh.p.pRRhop.hs+l.ul.p.s.u...h.t.hh.........................pp........t..p.s........s.......llas.Sp.aG-lp+shpllp.s..L..h..s..p..p.....s..l..S..PTsFu.SVHNussG.hoIhtpshsssouluA.upsoappuLhEAhshLpp..u...tppV.Lll.shDp....h......Pph..Yt.............p.s..hsaAlulll.p.s.usp....hp.hp.......................................ht.t.........tt.................tsh....hht.........................h.h.................................................................................................	0	34	79	119
+13566	PF13724	DNA_binding_2		DNA-binding domain	Coggill P, Eberhardt R	re3	Pfam-B_65234 (release 24.0)	Domain	This domain, often found on ovate proteins, binds to single-stranded and double-stranded DNA. Binding to DNA is not sequence-specific [1].	25.00	25.00	25.70	44.70	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.76	0.72	-3.82	15	45	2011-01-25 13:21:28	2011-01-25 13:21:28	1	1	14	0	35	46	0	56.70	41	16.04	CHANGED	MG.paRFRLSDMMPNuWFYKL+DMpKsRs+sstssstt...................ssouphppsSss	...MG..pa+FRLSDMhPNAWFYKL+DMp......+sRtpsssss.pt...................ssosppppsS......................................................................	0	4	19	27
+13567	PF13725	tRNA_bind_2		Possible tRNA binding domain	Coggill P, Eberhardt R	re3	Jackhmmer:P76526	Family	This domain, found at the C-terminus of tRNA(Met) cytidine acetyltransferase, may be involved in tRNA-binding [1].	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.23	0.72	-3.91	114	1005	2011-01-25 13:25:22	2011-01-25 13:25:22	1	12	956	2	333	715	7	106.60	31	13.55	CHANGED	Fc+Rh.....h.tLhu.hphpp..hs..........................h...ts..............................phsthlo.......................................shDh+RL....csYu.pshh.sacsl...lsh...lscLhhtthht..............hplssh....ppslLluhsLQp+sh-plsp-LsLsup...pt..l	................................................RRch..tLhp.as.hcs.ls.................................hts.....................................h.-ssLo.......................................................spDhp..c..L...suaA.hutt.shhss.....lss...LhRLl.ps.............................tl..........thshLhu+l.pptS.uplsppLp.LsGc..+..h...........................	1	106	180	269
+13568	PF13726	Na_H_antiport_2		Na+-H+ antiporter family	Coggill P	pcc	Jackhmmer:C5B988	Family	This family includes integral membrane proteins, some of which are NA+-H+ antiporters [1].	23.60	23.60	23.60	23.60	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.95	0.72	-4.07	42	1096	2012-10-02 15:12:49	2011-01-25 13:28:17	1	4	1056	0	144	1175	19	88.20	47	20.18	CHANGED	NAVllAVhlMLlLSLhR..lpVVlALhluAlVGGLlGGLulspT............lssFs.sGLGGGAplALSYAlLGAFAlAIo+SGLsclL.....Aptllphlu	........NsVlluVl.lMl.lLs.L..hR..lNVV.luLhluALVGGLlu....G.h....u....lsco........................lssFt.s.........GlssG.A.p.l.ALSYAlLGu.F.A.s.AI.S+SGlschLsppllphl.p............................	0	34	76	118
+13569	PF13727	CoA_binding_3		CoA-binding domain	Coggill P	pcc	Jackhmmer:C5BFR0	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.93	0.71	-4.44	56	4439	2012-10-10 17:06:42	2011-01-25 14:11:05	1	19	2789	2	1096	3621	674	172.50	16	32.80	CHANGED	thhslYps.hph+shhpths.clhtuWh.ls..h.h.h.h.hs..lha..t..h..p......s..h...hSR..lalshW.h.hsuh...sh.llhtRhll...tthl...pp.ht+....p...s....thp....htsl....ssss....uppht...ptl....p..pp.ts.u.h..h....h.l.GlaDDc.......s.ssp..s..h.s........uh..PhlGslspllchsRpsclcplalALPlssEpcIhcllpchtspsVsIRlhP	....................................................................................................h....hYp......h...h.th.h.p.p..hh..p....lh.t.shh..hs...h..l..h..h......hh....lsh........h.....h.....p............p.h.......hs..R.......hh..h..h...h.a........h....lhsh......hh...lh...h..hRh...hh.......+h.h.h.....................pp....hhp....................p............p................pts............hh..ls........usss....u...p...t.l..h....pt.l...........p...p.p.s.p....h...s...h..c......ll..uh....h..D-c...................t..s.tt..sp.....h...t...........................sh...s..l...h.G...s...h..p....p.l...............p....h..s.c.p........t..........p.....l...c.p........lhl...A....l.P.....s..t..t.ph.pc.llp.h.pp..h.s.sp.hhhhP...................................................................	0	367	716	919
+13570	PF13728	TraF		F plasmid transfer operon protein	Coggill P	pcc	Jackhmmer:Q9WTC0	Family	TraF protein undergoes proteolytic processing associated with export. The 19 amino acids at the amino terminus of the polypeptides appear to constitute a typical membrane leader peptide - not included in this family, while the remainder of the molecule is predicted to be primarily hydrophilic in character [1]. F plasmid TraF and TraH are required for F pilus assembly and F plasmid transfer, and they are both localised to the outer membrane in the presence of the complete F transfer region, especially TraV, the putative anchor [2].	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.16	0.70	-4.85	53	761	2012-10-03 14:45:55	2011-01-25 16:40:05	1	4	447	0	91	751	65	167.80	27	71.99	CHANGED	GWhWYs-s....p.pc.t........p..tsss...........ss....s....t.ts.................s....t............pph..ph..h+pthpchhspAlhpPo...ENltpahplQchhhc+uspFupsappslhppPpLDYslc.pP...h..sssutpshhp.tcp.pppp.pslppLu.ppaGLhaFYcu.s..ss.hspthusllpsFucpa.GhsllsVShDGshhs..thPpsch...DsGptp.plsl...p..hhPALhLVsPpo........tphtPluaGhhSp--LhcRlh	..............................................................................................................................................................................................................................................................tt.tpp.hltphs..pca..u..lh..F..Fh..pu.p..Cs.hCc......phsPll....pphu...p.p...Y....G...h.....s.Vhsl...o...l..D..G..tsss...............thP.phhs..............spu......hp....p.h..s.l.........h..hhPshhLlssps..........hph..hPls.Ghhs.spl.tp....................................................	0	24	44	71
+13571	PF13729	TraF_2		F plasmid transfer operon, TraF, protein	Coggill P	pcc	Jackhmmer:D2BTB8	Domain	\N	25.00	25.00	26.00	25.00	23.30	24.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.40	0.70	-5.59	29	545	2012-10-03 17:14:37	2011-01-25 17:05:16	1	3	385	0	74	341	4	257.80	36	66.69	CHANGED	AshhNPALluttp.p.Dc....hu.lllP..ulGspls..D.DplhDc.hDslpDshDthpsshss.p................tssscLsssLpsLcsspAhussGsuhu.....lulPsphlshuhhsKuYssuhstusl.spsDlshLpsht..................sss.ssLsSputshuusls-lGlAlA+ph.s..hss.hslolGlTPKhQ+lpsYNYssolpsaD..ssD.acs......scapsscouFNlDhGhshphscsaplGlsupNLlupc..l-Tpphp.............................uhp.TYplcPhhTs.GsAaps..chhTlusDlD	................................................................................................................ushhNPA...L.lAhhc.p..Ds......hu.llLP..ulG..hphs.....D..csl.sp.lD.clpD.....p.h-..acpss.s.t..............................tssspLscpLpt....hpspp.hpupsGsulA......sulP.spsl......uh......sh.......hsKuYupshVsupl...sss.shphlcph.................................s..ppthsS.sss....upus.hlo-hGlulAKph.s........huu.pplSlGl.............T.............PKlQ.+lhhY......sYss..o..l....p..sYD....tsD..acs.............sch..s-suFNhDhGss..h...ls....-..paplGlsupNLluR-..I-TKslt.............................shppTYpl+PpsTs..Gsuaps..DhhTsusDhD................................................	0	11	30	58
+13572	PF13730	HTH_36		Helix-turn-helix domain	Coggill P	pcc	Jackhmmer:C2JR21	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.65	0.72	-3.84	198	1833	2012-10-04 14:01:12	2011-01-25 17:46:11	1	15	1152	0	237	1777	177	53.80	25	20.10	CHANGED	pp.Lshp..sphlhhhlhshs..........ttt..sas..o..............pppl.......uphh.......shu.cp.....olpctlppLpctGa.....l	...........................................p.t.tthlhht.Lsshu...............sppsh..saP....o..............hppl.....Acph...........thu.cp..........TlppslppLcctGhl.........	0	81	149	191
+13573	PF13731	WxL		WxL domain surface cell wall-binding	Coggill P	pcc	Jackhmmer:C2JPG8	Family	The WxL motif appears in two or three copies in these bacterial proteins [1] and confers a cell surface localisation function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan [2].	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.73	0.70	-4.52	83	1929	2011-01-26 11:14:11	2011-01-26 11:14:11	1	25	266	0	120	1070	0	205.50	24	49.88	CHANGED	ssAtss....so......sso.sspVpFpss..............sVsPsss.s..s.....s...ss.lsP...DP.....sts........uo..sus......Lslsas.s.s.hsFGppp.Ios...ss...pshhup.........................p.h...t...t.st............ptss......hlpVsDhRG..Tpp.....GWpLospts.p...h..psus.....tp.........pLsGu.p..................lshsssphts.ss.ss...ss...................sPsshss.s......hsls......Gs..........susslhsAssupGt.GsWhhpass...........................p......slsLslPupshK......AssYTuslTWsLssuP	............................................................h...............hto....l.h..s................P.ss.s.............shps...s.......sts..........ss..sGsLslsh.s..s.s...hsFGp.p....Ios...ps...psahsp.....................................................s....p.h....t.sss..............ptss...alplsD.....t.R.G..Tps................GWp.Losp.s..p...Fpsss...........tp.........pLs...Gu..p..................lpht..ss..ss..ss..s...sp...ss..........................sPss.pt....s.........hsls....s..ss......................ss.sslh..s...A......s......p......s.........pGt....Goa..h.hphsp.....................................p......slpL.p...V...Pusssp......utpYpsslTWsLsssP.............................................................	0	60	97	102
+13574	PF13732	DUF4162		Domain of unknown function (DUF4162)	Coggill P	pcc	Jackhmmer:C2JJQ9	Family	This domain is found at the C-terminus of bacterial ABC transporter proteins. The function is not known.	27.40	27.40	27.40	27.40	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.69	0.72	-3.47	129	1360	2011-01-26 13:50:07	2011-01-26 13:50:07	1	3	1176	0	282	884	167	84.40	27	28.07	CHANGED	Gslp-lKcpaGc...pp..lhlc....sc...tshp.t.....Lppl.......sGltph......p.p....p.p...ss...h..p..lp.lp.s.p..p..su.pp.lh.ptlspp..u.h.lppFp.ptPSLs-IFlcpV	....................................................Gslp-l+pp..aGp...pc...lhlp........oc....tshpc.........Lp.sl....................sl.pps.........p.h......p...p....pG.....h..p...lp..lc...s..-..s.......su...pc.lhphlspp.uh.lppFp.ptPoLp-IFhpt......	0	107	202	246
+13575	PF13733	Glyco_transf_7N		N-terminal region of glycosyl transferase group 7	Coggill P	pcc	manual	Domain	This is the N-terminal half of a family of galactosyltransferases from a wide range of Metazoa with three related galactosyltransferases activities, all three of which are possessed by one sequence in some cases.  EC:2.4.1.90, N-acetyllactosamine synthase; EC:2.4.1.38, Beta-N-acetylglucosaminyl-glycopeptide beta-1,4- galactosyltransferase; and EC:2.4.1.22 Lactose synthase. Note that N-acetyllactosamine synthase is a component of Lactose synthase along with alpha-lactalbumin, in the absence of alpha-lactalbumin EC:2.4.1.90 is the catalysed reaction.	21.30	21.30	23.20	22.20	20.80	21.20	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.83	0.71	-4.80	4	775	2012-10-03 05:28:31	2011-01-26 16:12:21	1	14	122	59	468	672	185	120.50	40	36.04	CHANGED	CPphsPlLVGshpV.Fp.VPSLs-IVcpss+l.PGGRa+PsuC.sRs.....RsAIIlPaRuRccHLRlLLY+LH.FLpRQQLsYGIaVIcQtGNGsFNRAKLLNVGhhEALp...aDChhLHDVDLLPEND+NLYsCs.p	................................................................................................h.........t........l...GG.pa.p.P....pCh..stp...........+lAl.llPa.R......s............R....p..c.HLhhhl.aLH.PhL......pR....Q....p....l....casIYVlpQs.s.s..t...h.FNRAtLhNV...Ga..h...EA.h+..c........s.....a..D..C...hlFHDVDLlP.s.D+.NhYtC........................	1	160	192	326
+13576	PF13734	Inhibitor_I69		Spi protease inhibitor	Coggill P	pcc	manual	Family	This family includes the inhibitor Spi and the pro-peptides of streptopain (SpeB).  SpeB is produced as a 43 kDa pre-pro-protein, which is secreted via the recently described Sec secretory pathway Exportal. There is tight coupling between this inhibitor and its associated protease: the gene for the inhibitor Spi is located directly downstream from the gene for the streptococcal cysteine protease SpeB, and the sequence of the inhibitor is very similar to that of the SpeB propeptide. This is an example of an inhibitor molecule that is a structural homologue of the cognate propeptide, and is genetically linked to the protease gene [1].	21.90	21.90	22.10	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.30	0.72	-3.88	3	136	2011-01-26 16:26:11	2011-01-26 16:26:11	1	5	74	14	8	126	3	109.20	27	17.66	CHANGED	M.........................................E.pF.RopsEAhtlApoFhupssp.................oKspLRlppLS..hPsDT......LaIlAL.s.GGFlLVSGDTRh.slLuho.csNLDhspssV.shlsVFtcQl....................................NFu-	.................................................t..........pAhphA.p.ah...tps.t..t......................pp.hp...h..psp.thu.........ss..ss..............shYlaNh...sss.GFVIVSGDcRss.pILGYSppGsh..D..h.s....p..t...N..ltsh..hpta.p........hth.........................................	0	2	6	8
+13577	PF13735	tRNA_NucTran2_2		tRNA nucleotidyltransferase domain 2 putative	Coggill P	pcc	Jackhmmer:C2JK63	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.52	0.71	-4.39	46	1530	2012-10-01 20:28:14	2011-01-26 17:21:14	1	13	1500	6	255	1460	430	149.20	25	36.36	CHANGED	hphpspppuWuhLhhtls.h...ppspsFL+sWKhSNchI+pVppllphlphhp.......ppphsth....pl.....YphGpp...hhhhs..ppl....tph...hs.hs............hsh........pplppha..psLPI+.......s++-LslsGtDLlpthshpPGPhlGclLpplEptllpGclsN-cculhpas	.................................................................................................................hhh...t..........pp...spthL+.phKhS.N.p.h.h+p...l...ppllp..hhphh............................ppphp.ph.........l...................Yc.h.s.hc...........hhhps....pl...........tps....ht.ts...........................................ssh.....................ptlpchh.....pp..L.....s.....l.+.....................s.p.+..-....l.....s.....lsGscLlpt.h.uh.p....s.GPh.lG-lLpplEtullp.Gpl...p.Npcctlhpa.......................	0	109	180	216
+13579	PF13737	DDE_Tnp_1_5		Transposase DDE domain	Coggill P	pcc	Jackhmmer:Q6D6U8	Domain	Transposase proteins are necessary for efficient DNA transposition.  This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	27.00	27.00	27.00	27.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.34	0.71	-3.91	55	810	2012-10-03 01:22:09	2011-01-26 17:53:35	1	3	314	0	228	802	109	97.70	47	42.18	CHANGED	hpRGSLThWlDpch..tW.hs..s.p.G+RGRsptaSDsAIpss.LhlKslFsLPLRtspGFlpSLhcLssLshssPDaSolsR...Rt+slsVslsh+ssstu...lHLllD.STGlKhhGE	...............................hpRGulThWlDtcs..tW.tt...spp.spRGRsppaSDhAIpss.LhlKplFphsLRtspGFlsSlh.pL.hsl.sltsPDYos...lSR...RtKplslsh..............p..s.scu......hHLhlDuTGLKhhGE..................................	0	16	73	111
+13580	PF13738	Pyr_redox_3		Pyridine nucleotide-disulphide oxidoreductase	Coggill P	pcc	Jackhmmer:C2JNY9	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.64	0.71	-4.26	38	7189	2012-10-10 17:06:42	2011-01-27 11:41:36	1	104	2015	19	2924	28500	10134	196.30	22	41.32	CHANGED	hVlGAGssGhuhs.stL....hcp..sh......s.s......llllD....pttp...sGup...at...p..h..h..........spl..hp.....P.uh.h........shs...h........shtth.shsst.s...th....h...tph....sous-.l..s.p...........Yhpplhcph....hl..s.......lp..htspls.tl...p....ts................s..st...ap..lps..ps..t..................plp...sctll.usG...hhtp..P..ph..s..hsu................s....t....ps.l...ths....pl..hsh..t...........c.....h..ts.....pphsVlGuG...+oAhssshtLhct.....u...p......c...lshlt.ppsshh	................................................................................................................................hllGu.G......uG.luhu...hp.L........ppt....Gh.......p................................hhllE.....................p..t....t...p.........h.G..us..........Wt.........p.....h.......................................................................................h.....................s...s.........................................................th....t.h.....s.h.t........................................t............pt.h......................ss...t....s....c....l.......h....p........................................................................................................Y..l...p....p.....h.......s...c..c.a............sl...p...............lp...h..s...s...c.....V....p....s.s......p.......hs................................................s..sp.......ap......lps.....pss.....................................................php.......uch.llh.AoG.....h.h.sp.....P...p..h...P.s....lsG.........................................t.....t........ph..h........H..s.s..............pa......pps....h..........................s.......h....p.u..............++V.s.VlG.uG..........s.SA.......h..p.hs.....p..lspt..............u......t..............p..lshh.Rp......................................................................................................................................................................................................................................	0	721	1687	2444
+13581	PF13739	DUF4163		Domain of unknown function (DUF4163)	Coggill P	pcc	Jackhmmer:A7HM60	Domain	The structure of this domain is and alpha-beta-two layer sandwich, identified from a Fervidobacterium nodosum Rt17-B1 like protein. The function is not known except that it is found in association with Heat-shock cognate 70kd protein 44kd ATPase, Pfam:PF11738.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.40	0.72	-3.23	48	615	2011-01-27 14:33:03	2011-01-27 14:33:03	1	13	479	2	148	539	7	102.50	19	37.12	CHANGED	slphpphp...hp..s..shhp..h.plphPhlps.hp.spphppplNphl..cppstph..............hpc.........h....c....ct.upc.....th.......cpshs........hs..Ythps.....saplphs....ssshLSlhh.shYpYo.GGAHGhTs	............................................................................s.........p..p...hhp..h.plphP.hp.....s...t..spp......hp......p...p....l..Nphh...pp.p.spph..........................hpp.........h....p....pptpc...........ht.............pps............hs...aphps.....saclphs....psslLSlhh.shYpYs.GGAHG.....................	0	60	110	125
+13582	PF13740	ACT_6		ACT domain	Coggill P	pcc	Jackhmmer:Q6D7R4	Domain	ACT domains bind to amino acids and regulate associated enzyme domains.	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.02	0.72	-4.26	82	3060	2012-10-02 00:29:19	2011-01-27 17:00:36	1	22	2494	6	650	2293	345	75.40	27	39.29	CHANGED	phLlIoshGpD+PGlssplsplluptsssIlDsp.AhltsphoLhhLlpss.........ts..sh..splppsL.hhupchsl....tlhhp	...........hlITllGtD+sGIlsslophlupt.s.....sNI..hDh..p........s...h....l....s......s....t....F..o..h..h.hlls.ss............ts...sh....s..tlc..ssLtth.utplsl.l.h................................................	0	198	402	547
+13583	PF13741	MRP-S25		Mitochondrial ribosomal protein S25	Coggill P	pcc	PfamB-B_2836 (release 25.0)	Family	This is the family of fungal 37S mitochondrial ribosomal S25 proteins.	25.00	25.00	25.10	25.90	24.50	24.90	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.54	0.70	-4.89	31	140	2012-10-03 14:45:55	2011-01-28 09:39:44	1	4	131	0	108	137	0	205.30	38	81.68	CHANGED	M..KlphpAspVhppsos.lpu....GhlpppPsWaslVushPPsp..phsRp.hhpp..sppphtph...tp..................hhcsp.pth..+pppssplapss+lpa.EDpLRchFa+pHPWELuRP+lllEss....Gc-..tchDWS+.hpQhsKsLDGESVVQRsLaLlps.....pshohhcAYDhARhEFY+LRhpEEl-ppVAtEEAchaGAsFusopl-hGhphEpchl-sWcphApppoplhpuc	................................thphpAhp.Vhpps.t.hps.....Gh.h.....pptP....sWhsllsslPPsp..hhsRp...pp..stphhtp.......................................hps.p..t.....ppppspclapP.c.lpY...EDpLRp.Fa+-HPWELuRP+lllEss.......GpD..pphDWS...+.lp..Q.G+.LDGE.............SVVQRpLaLhps.................tshohtpAYDhARtEFYpLRhpE-lEp+VAtEEAchhGAhFG.s..tlphGhphEpp.h-pW+thAtpcsphhpt.t.........................	0	28	59	92
+13584	PF13742	tRNA_anti_2		OB-fold nucleic acid binding domain	Coggill P	pcc	Jackhmmer:Q5FCF9	Domain	This family contains OB-fold domains that bind to nucleic acids.	27.00	27.00	27.00	27.00	26.60	26.80	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.21	0.72	-4.14	80	4104	2012-10-03 20:18:03	2011-01-31 09:50:30	1	5	4053	0	822	3044	1031	97.40	34	22.09	CHANGED	hhols-Lsshl+pslcs.s...sphaVpuElSshpt...ps.GH..hYhsLh-............sp..Aplpushapsphptlp.........hp...............................psGhcVllpuplsaat.hG.....hslhlpclcs	............hoVopLsphl+thl-p..c..h..spValpGElSNhpp...sS..GH..hYFoLKD............cp.......Aplp..sshF+..ss..sp+ls...........................Fps..........................ccG.pVlVpuclolYEspG...........sYQlhlcphp.............	0	260	536	693
+13585	PF13743	Thioredoxin_5		Thioredoxin	Coggill P	pcc	Jackhmmer:Q5HAE0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-10.83	0.71	-4.71	36	777	2012-10-03 14:45:55	2011-01-31 10:34:12	1	1	761	6	119	791	73	177.00	31	71.20	CHANGED	YlFlDPlsscCaphEstlpKLth-.....Ysphhpl+alhhspLpslsttttp......................hshssssh..hpp.hsssY.uuLAhKAApLQG++tGtpFLpcLQctlhlp+pslop.-llhphApps.GLDl-.FpcDhcSshApcuapsD.+lupEMsVppsPThVhFN..ps.c-pGlplpGhhsYcla.p	.....................................................................................................................................YhFhDPhsssCaclcshlh+Lph-.....as..p...h..l...p...l..R....a..Ihs...s.....s.l..p..s.lsps.tp....................................ths.p.h.....p.pss..s...s..h..as..s..u.L....A..hK...AA.c.L...........Q.........G..+.c......cu.c.c...F.L.c.tl...Qptl.hlppps.hss.......ph...lhch....h......pss......G.....lDl..-....hF+c...Dh...p...o...st.h.p.c.uhp....p.Dh....+lA.pE.MpIpptPolVhFs...ps.c-pGlhlpGhhshchh...........................	0	33	73	99
+13586	PF13744	HTH_37		Helix-turn-helix domain	Coggill P	pcc	Jackhmmer:Q5HBM9	Domain	Members of this family contains a DNA-binding helix-turn-helix domain.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.09	0.72	-4.17	55	1158	2012-10-04 14:01:12	2011-01-31 10:40:40	1	9	818	4	307	2718	211	79.70	24	74.93	CHANGED	lapDhuhscucphp.....hKupLhht....ItchlcpppLoQpcAAphhslspPclSplhcu+lsphSl-pLhshLstLGtcl-Islp	...................................................pttt...t..............h+s.p.lh..ht..........lp.phh.cp..pt....h...o..QspsA.phhGloQPpl.Sc.l.p...t...+...h....s....p...h...s...l...ssLhphl.s.t.h..Gt.clcl.h........................	0	67	178	251
+13587	PF13745	HxxPF_rpt		HxxPF-repeated domain	Coggill P	pcc	Jackhmmer:Q6D9B1	Domain	This family is found in non-ribosomal peptide synthetase proteins, and can occur up to twelve times.	24.10	24.10	24.10	24.10	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.81	0.72	-3.67	1348	6665	2011-01-31 11:02:57	2011-01-31 11:02:57	1	1095	1165	1	2334	7456	120	92.30	29	5.06	CHANGED	sHQDlPFEpLV....-t.L..p.s.p....R.shu...+.s...PLFQVhhsh..p......s..s.....s.......t....s...t.........h.p.l.....sG.......L..p.lp...sh...s...h..s....t..s.....su+FDL....slpl.tE....ps......s.......s....lpsshpYso-LF-psTlpch	...............................tHQDlPFEpLV.......-t.L..p.....s..p..............R...sh...u...........+..s...PL.FQlhhsh.p..............s.t......s...............t.....s.t.............................h.p.l........su..............l...p..lp.....s.h........s.....h...s.......s..s......................su+F.....DL....slpltE......ps..........s...........................s..lpsshcYso-.LFctsTlpph............................	0	609	1300	1915
+13588	PF13746	Fer4_18		4Fe-4S dicluster domain	Coggill P	pcc	Jackhmmer:Q5FDF3	Domain	This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.46	0.72	-3.55	40	1675	2012-10-03 08:56:43	2011-01-31 11:20:17	1	15	1374	0	499	3018	1748	74.80	36	17.46	CHANGED	lChahCPasR....................hQ.usMhDp...colslsY....................c.ht.hp........................scs..........................ct....ttpp....hcphp...........................pst....shGcClD..CstClpVCPsGIDIR	.................................................................................hChahCPasR.............................hQ..ushhDp.......so..hh.ls..Y.................................................................................c..hc.tt........................tpt...........................p........hh+t...hcpht...............................................c.tt.....shG-ClsCstCVplCPsGIDIR......	0	164	331	422
+13589	PF13747	DUF4164		Domain of unknown function (DUF4164)	Coggill P	pcc	Jackhmmer:Q5HAR4	Family	This is a family of short, approx 100 residue-long, bacterial proteins of unknown function. There is several conserved LE/LD sequence pairs.	27.00	27.00	27.00	27.10	26.80	26.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.84	0.72	-3.85	32	182	2011-01-31 11:46:12	2011-01-31 11:46:12	1	3	165	0	69	156	20	88.10	45	84.00	CHANGED	ssssplptAhpRLcsAlspLEsAl-pRh-tccst......s-hcscl.ptlssDRuRLApELDputsRsp+LccsN+ElucRLssAhEoIRuVLsc	................s...stLcpALcRLcpAlssLEpAV-hRl-.p-pch........uEhEpEl.Q+hsADRSRLApELDpu-uR.u.cRLEtsNREVS+RLs....oAMETIRuVLD................	0	12	39	48
+13590	PF13748	ABC_membrane_3		ABC transporter transmembrane region	Coggill P	pcc	Jackhmmer:Q6D8M5	Family	This family represents a unit of six transmembrane helices.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	237	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.37	0.70	-5.33	20	130	2012-10-02 13:23:42	2011-01-31 14:29:18	1	3	117	0	24	160	15	207.20	47	78.77	CHANGED	L+pIs+patt+LhlTasLVlAENsLhlhYPLhuGFAIsullsGsstpAlhYuslVllhWllGuuRRtlDTRsFuRIYscLAVsVllsQRppstssSolsARVsLSREFVDFFEpHLPhLhTSllSlsGuslMLLslEFhlGlusLslLhhhhhllspas++NppLat+LNNcL.....E+-VsllspsptpsLp+HYchLu+LRItlSDREAhuYhhIGlstulLFshslhhhohpssssAG	......................................LKtlsppa+K+LhhTF.LVshENl.LhLhYPlhuGaAIN....A....l.......l.s.G.p.s.......hpA....l.h....Y.A.ll..V...llh....WllGAARRhs....D....TRTFs....RI....Ys....cl.........AVsV....l......l.p......QR......p.......p..........p..h..spS........sls........AR......V.....u......L....S....R.E.F...V.s.FFEcHLPhhhTSllSlhGAslMLLllEFWlGluul...s...ILshhhhl...LPpFsth.......s-pLah+LNNpL............E+-schlppu..st..ppLhRHYshluRLRlhlSsREAhuYLslGhuhulLFuhshshhohpshsoAG..........................................................	0	5	10	18
+13591	PF13749	HATPase_c_4		ATP-dependent DNA helicase recG C-terminal	Coggill P	pcc	Jackhmmer:B0G2L3	Domain	This domain may well interact selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	25.60	25.60	25.70	25.60	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.56	0.72	-4.19	156	1792	2011-01-31 15:44:31	2011-01-31 15:44:31	1	38	1018	4	435	1610	115	86.20	24	18.82	CHANGED	GsplplplacDRlEIpsPGslhsslshcp...hhst.s......spsRN.hlAslhpch.............s.......h............h.......E......ptGoGlp.+lhpthcp....tthstPpa.p.s...ss..sp..hp..Vsl	..........................................lplpha....sD.RlEltsP..Gsl...sloh.....-p.....hhst.............stsRNshluplhpph.............s.......h.............h.......E......phGsGlp.+.lhpthpp....hth...tPph.p..p..pt..st..h..hh.........................	0	146	311	382
+13592	PF13750	Big_3_3		Bacterial Ig-like domain (group 3)	Coggill P	pcc	manual	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	27.00	15.40	27.10	15.40	26.90	15.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.96	0.71	-4.80	8	166	2012-10-03 16:25:20	2011-01-31 16:04:29	1	38	89	0	42	589	311	132.50	27	12.60	CHANGED	ssaphsFshssLP-GpYollt.sApDpasN...ssspoht.sltlDsTsPolsl....ttslu-GuslpGLEsLcIoLsDshssu..sLoSlsLsGGPssDpVpLoWsstGcshYtLpYPRlFPSL.csGEoYTLTVsApDstGNssspossFpYhPsNLlplcsL	...................................................hthpas.h..p.tls.-G.pY.s.l.s.s..tApDthsN.....sss.p.s.ht.....p...l.......s.h.D.s..T.s..P...sl....sl........tss...s..s..ss..s.....l..s.l....-...s...l....h...I.s..l..s..D.shs.s...pls..ph...t..L..hGG.ss...s......-..t..l....pl.sh........u.ps.h...a.h...pYs.h...h..F...P..s.........h..p.....s.p..Y..plss.s.DttuNhhp....ts.tFpY...P.............................................................	0	6	17	34
+13593	PF13751	DDE_Tnp_1_6		Transposase DDE domain	Coggill P	pcc	Jackhmmer:B0G2Q7	Domain	Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.66	0.71	-4.12	60	2925	2012-10-03 01:22:09	2011-01-31 17:05:27	1	17	1173	0	565	4140	496	101.80	25	32.07	CHANGED	hCPtGpph.phptp.thtt..t.p..s.hs...thht.aps..p..sCpsCPh+ppC..sps........pp..sRpl...ph.p.p....h.pp.h.t.pcsccp...h...poc.ttpphhppRs.slEsshupl+pphuhc+h.ph.RGhp+sphphhhsshuhNlc+lh	..............................................................p..t...............................t......................t...Ct..t..C....h........C................................t.....hh......hp.........pt..h...t.tp.hp..pt..........h......ho..t..t....s.p.p.h..ht....p.Rp.slEtsF.uphKph.h.Ghc.+.h..ph....RGh.pp..............sphphhlshhuhNl+Kh......................................	0	215	392	444
+13594	PF13752	DUF4165		Domain of unknown function (DUF4165)	Coggill P	pcc	manual	Family	\N	25.00	25.00	25.00	95.80	24.60	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.54	0.71	-4.36	10	99	2012-10-03 16:25:20	2011-01-31 17:26:11	1	4	41	0	8	59	2	123.90	43	11.92	CHANGED	ssApAplhpYSFTDTsusp+olpPuo.salNPs..oslolsL.uGLDRhl+loVh+ouush.hhoosTo+lhsAschlossGs-YYGKclsLPAL.uEGsaoL+sElLsssGssVuopsYslsIDTTuP	.s.sApAplhEYoFpsssGsp+olsPss.sYlNPs..uslolsL.uGLDRhl+loVh+usGo..lhSTsTo+lhsAschhussGp-YYGKclsLPAh.uEGsaolcs-ILs.sussVsTssYshtlDsTPP.......	0	0	0	3
+13595	PF13753	SWM_repeat		Putative flagellar system-associated repeat	Coggill P	pcc	Jackhmmer:Q6D875	Repeat	This family appears to be a repeated unit that can occur up to 29 times in these outer membrane proteins. It is putatively associated with a novel flagellar system.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.64	0.70	-5.38	14	4913	2012-10-03 16:25:20	2011-01-31 17:42:37	1	401	519	0	1126	8114	1151	233.00	21	45.74	CHANGED	TPss..pp..ssssh..plsls...lpDssGNss..s.s..o.....ts.hs.lDTc.......PpVsls....Iocscl.sutpssssh...oFotssos.hsssshh.hsss.....s.Gsh.....GuL....o......ls.osG.p.Wossh...TP.........ps..slpsu.-soI.pVs..hVpDstGNu..............s..su..sossh.oIDTt.......PpVoVo.............Ioss....cltuGpssTsTFTFsEsV..o.GFstsDs.sho.....sGThG.LssVG...oDGhsWosshTPps..spss-s....slpVs..As.VpDAtGNAs...ou.....S.s....sa.olDT......ps.Pplolsh...uDshls....usEsus.Thshotsls.shsssDs.h.....sos.pG..s...hss.T.....sVss...su..p.aosshssts..stssssT	.................................................................................................................s.................................st.................................h....h...............s..............ht.......................s...............................s.............h......t................s....h..p..................h........t..s..s....t.....t.l....l.h............s.G.t....................h.s.h............s.........hs...ssG.....s...Woh.sh........ss....................................s........sL.ssG...s.h...s..l....sss........ss..D.hs....G.N.s..........................................................s...ss.........o.h..s.h..sl.D...st...................s..s......l...s...l...s..s..................................................................................................hs...ss.............s.l.h..s..s...s...p......h.......s..........s....h.s....s..t.s......s..s.h......t.s....s...p....h....l..p.lsh...........sG...t....h...h.....ts.s...st............s..s.G....sW.s.h..s.h....s.s..s.........t....h.s.su.............sh..s..ls.....ss....spD.huGNss.....os......s..................sh...s..l...D..s.............th...s.....s.....h.....t.....h.....s.....................t........t............................................................................................................................................................................................ss.......................................................................................................................................................	0	251	639	891
+13596	PF13754	Big_3_4		Bacterial Ig-like domain (group 3)	Coggill P	pcc	Jackhmmer:B0G3A4	Domain	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in a variety of bacterial surface proteins.	30.80	30.80	30.80	30.80	30.70	30.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-8.88	0.72	-3.64	416	7056	2012-10-03 16:25:20	2011-01-31 17:55:29	1	431	622	0	1020	10654	674	55.10	32	17.22	CHANGED	Gp.s.h...s..s.ss....s.....ss.....GsWo...h.....s.....s.....s.....ss...s.......-G....s.a..s..lo..l..suoDsAGNs.u.ss..s.s.s.....l..s.l..Dos..sP	.........................................................s..s.s.s.....s........ss...GsWo....a......T.....s.............s........ss..hs............-G.....s.a...s..lo..l..sAoD.s..AGNs.u.ss.......s.s.h.s...l...s..l......DTps..............	0	174	349	751
+13597	PF13755	Sensor_TM1		Sensor N-terminal transmembrane domain	Coggill P, Eberhardt R	re3	Jackhmmer:A3JX63	Family	This domain is found at the N-terminus of the sensor component of the two-component regulatory system. It includes a transmembrane region and part of the periplasmic region, which is likely to be involved in stimulus sensing [1].	21.90	21.90	22.40	22.60	20.80	21.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.40	0.72	-4.47	43	271	2011-02-02 10:44:03	2011-02-02 10:44:03	1	3	271	0	92	230	114	76.40	43	13.15	CHANGED	RtRRuhhslptSsLTR+IlshNLlALslLVuGlLYLNphR-uLltpRspuLlopuclIAsshtAp...ussssshsosDs	.........h..t+hhhphhhSSLTRRIlhlNLhALslLVuGILYLNQFRpGLI-A+lpSLhsQucIIAuAluAS...usssss.hhhDs...............	0	27	58	69
+13598	PF13756	Stimulus_sens_1		Stimulus-sensing domain	Coggill P, Eberhardt R	re3	Jackhmmer:A3JX63	Family	This domain is found in the periplasmic region of the sensor component of the two-component regulatory system. The periplasmic region is likely to be involved in stimulus sensing [1].	29.70	29.70	30.20	29.70	29.30	29.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.46	0.71	-3.68	35	203	2011-02-02 10:46:24	2011-02-02 10:46:24	1	3	203	0	75	162	67	111.60	43	18.97	CHANGED	lsPEpVuPlLRRLhsPT.poRARlYDt-GpLlh....DSRsLh.....spuplhph-LP.Psc.sppsshhcphhphhpphh.ts...............cLPlapE.hssssGptasEVtsALsGp.hssslRhspcG	.......INPE+VuPlLRcL...ISPT.pTRARIYDppuslLL....DSRsLY...........upGtVlRaDL........P...Plc..s.c..........p.ss.lh.......ERhhshlpphh.su...................sLPlYpE.tssusGtsY...EVhpAL.s.Gs..tsshRhsp+G...........................................	0	23	45	55
+13599	PF13757	VIT_2		Vault protein inter-alpha-trypsin domain	Coggill P	pcc	Jackhmmer:A8MTC4	Domain	Inter-alpha-trypsin inhibitors (ITIs) consist of one light chain and a variable set of heavy chains.  ITIs play a role in extracellular matrix (ECM) stabilisation and tumour metastasis as well as in plasma protease inhibition [1].  The vault protein inter-alpha-trypsin (VIT) domain described here is found to the N-terminus of a von Willebrand factor type A domain (Pfam:PF00092) in ITI heavy chains (ITIHs) and their precursors.	23.00	23.00	23.10	23.00	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.48	0.72	-4.52	10	116	2012-10-10 13:59:34	2011-02-02 13:41:04	1	10	54	0	56	544	59	76.80	45	8.33	CHANGED	PGLlNhpotss...............LPLpuSclsuClpGhuLuhTAoLTYtNspstsl-Gs.FlaPLs-sssVlGF-AhluuRhlssplppcs	.................................................PGLhN.tohss...............................LPLosSsVsuClsGhsLulTApLTYtN..p.s...p.P...h.-Gl..FVYPLsE.spsVsGFEAh.lus.RhVohQlps+.u..............	0	11	18	34
+13600	PF13758	Prefoldin_3		Prefoldin subunit	Coggill P	pcc	Jackhmmer:P43573	Domain	This family includes prefoldin subunits that are not detected by Pfam:PF02996.	23.40	23.40	23.40	23.40	23.30	23.30	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.10	0.72	-4.22	23	73	2012-10-02 17:27:01	2011-02-02 13:51:44	1	5	73	0	60	162	0	97.40	41	15.65	CHANGED	pcSlh+W+ph.u...EY-uLK-ElssL.............scsuop--llcluR-FsGoLVsEcElctILGc...pp...slpRo+pQVl-lloRRIDYVppNlsTlEKRlcsAEs+Ls	..........................................pcSLhHWphW-AEY-uLKEElpsL.....................sssp--...llc...Iu....R..-...F..s....GsLVsc+ElctllGc...pp....thpRotpQllshlsRRlDYVppNlsoLEKplcsAEs+L............	0	10	27	47
+13601	PF13759	2OG-FeII_Oxy_5		Putative 2OG-Fe(II) oxygenase	Coggill P, Eberhardt R	re3	Jackhmmr:A3JXF3	Family	This family has structural similarity to the 2OG-Fe(II) oxygenase superfamily.	27.00	27.00	27.10	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.37	0.72	-3.73	92	313	2012-10-10 13:59:34	2011-02-02 14:23:49	1	52	193	4	101	350	4039	98.90	26	31.52	CHANGED	ssWsslhp.pGshpssH...hH...ssu...hlSGshYlpss.p..ss............u......shph.ssc........hshh..hs.s.s.h....t.....t...t....tshhh....lpPc.s.GplllFPSaLhHpV.hs.tuc..tpRlSluFN	............................t.hWhsh.hp.pG.shpssHhH....ssu...hlS.....GshYlp.hPp....ss...........................u......shth.ssc..........tthh....hs...t.s.........t......t..t....h..tshhh....hpPp.sGplllFP.SaLhHt...V...s.......t......up.......p.....pRloluFN....................................	0	39	72	89
+13603	PF13761	DUF4166		Domain of unknown function (DUF4166)	Coggill P, Eberhardt R	re3	Jackhmmer:A3JYW7	Family	This domain is often found at the C-terminus of proteins containing Pfam:PF03435.	23.00	23.00	39.70	39.60	22.80	22.50	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.14	0.71	-4.36	56	283	2011-02-02 14:29:42	2011-02-02 14:29:42	1	4	268	0	77	250	15	170.60	31	72.13	CHANGED	LsstlpchHuh....tss...s..hhpGpsclt..tusp...hhs.....+h.lstl.....ht......hP.....psupplPhplphps.....sss...up.....pWpRpFst.........ptFcSph.h...st..s...sshlhEthG.....s...hthpls....lps....p.s.GuLchpspp....hph....hG....lPLPth.Ltspupsp...Ethc..-......spapFcVclphPhlGh.lhpYpGphp	.............LtPtlpcpasl.......psshshpGphcph..huus.....hhs.....+h.lhtl.....ht.......hP.....cpGpclPhslpsps.....pts..sp.....pWsRpFhh.t.h.+hFsush.h......st..p...........pstll-ahG.....t...lthpLs...lps..............c.p.GulphpSpc...hh......hG...hlPLPpa...Lh..spupsh...EphD..-......ppF+hcVpVpsPll.Gs..LhpYcGpF...	0	18	47	62
+13604	PF13762	MNE1		Mitochondrial splicing apparatus component	Wood V, Coggill P	pcc	Jackhmmer:P24720	Family	MNE1 is a novel component of the mitochondrial splicing apparatus responsible for the processing of a COX1 group I intron in yeast [1]. Yeast cells lacking MNE1 are deficient in intron splicing in the gene encoding the Cox1 subunit of cytochrome oxidase but do contain wild-type levels of the bc1 complex.	20.00	20.00	20.00	20.00	19.90	19.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.68	0.71	-4.12	10	32	2011-02-02 14:48:45	2011-02-02 14:48:45	1	1	31	0	20	30	1	146.20	25	23.00	CHANGED	s.hpsShhGslhsNLpshpcaIpsHhsYhpppshspshpslFlNslLsHlslapNaouhlphLcsl........phlpssshs...sahcssoF+lIhpSl.SNSsSuKlsuhtLasaLKp..pcl.........plTscsYpsLlpusL+G....ta+-sl.FYlYcYLpsa	....................h.s.phusl.hNLpshpcalpph.p.hpt.pshppsh+shFIsslLsHls.stpsashhlsllcpl.........hL.ssslh...s.hcssoa+hlh+uh.SpssSsKhshhtLasaLpp...sh.........phospsahphlpsshph......p-hh.Fahaphlhs..................................	2	2	9	19
+13605	PF13763	DUF4167		Domain of unknown function (DUF4167)	Eberhardt R	re3	Jackhmmer:A3JZ71	Family	\N	25.00	25.00	35.50	35.50	20.60	19.70	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-9.78	0.72	-3.96	45	295	2011-02-02 15:58:01	2011-02-02 15:58:01	1	1	292	0	94	262	1061	82.10	52	35.05	CHANGED	RuR......s.pss..........p....spt.ppss..Ns..hsR..sa...-S....sGPDs.KlRG..oApplhEKYppLARDAtuuGDRVhAENYhQHAEHYhRllsst.ptptp	...............................sRs.pss...........s....Np.s..+pss...Ns.....hsR..sa....-S....NGPDl.KlRG..sAQpIhEKYtpLARDApuSGDRVhAENYhQHAEHYhRllsuAptp........................	0	26	59	71
+13606	PF13764	E3_UbLigase_R4		E3 ubiquitin-protein ligase UBR4	Coggill P	pcc	Jackhmmer:B3KMT2	Family	This is a family of E£ ubiquitin ligase enzymes.	23.00	23.00	41.20	31.10	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	802	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.72	0.70	-13.40	0.70	-6.66	16	189	2011-02-02 16:43:37	2011-02-02 16:43:37	1	17	115	0	133	204	7	616.10	39	20.09	CHANGED	MspNPYSSs-.ulGPLMRDVKNKIC+ph-LluLLEDD.GMELLVsspIISLDLsVpcVYEpVW......................pts.......tp....................ssPMslsYRhpGL.G-ATEphI-pL...pssp-EppDsEtpaphAulh.p-CGGL-shLshltplp.c......hpusp-hlshlL+LLhaCsKl+pNRptLLp..lGALshLLcshppAassss.......htluEplL......................hIhEollpEAs.pssluts.s..hpsss..............................s..pchlthFL-pls.....ss..hh+sNtp...hctlsRllPhLoaGcspsMcsLlcaF....cPhL.p....F-phDp...............c+.s......s-p.............p..ht..lEsFs+lu-ulcssssGc+LK-hIlppGIsptAhpYlccphsss.....tpp...s.SsEWtphLp+PSLPhlLphLpGLupGH.sTQpt.lc.cshI.slLHtLEpVou.-pcIGoLAENLLEsLuc.ppt.....lsc.....plpplRctT+tEp+RhAhtpREchLpsLGMch....sp...tG..pl..l.su.ssllcshE-lc...E.E-GLsChVCREGYsh+PsclLGlYoFoKRsslss...........sp.spt.pts.....................hsYTTVSHFNllHapCHpsAhR....Lpps....+cEWEuAuL+NupThCNsLhPlhGPpVspusaspslspahsslpslup.tsssphph..hs.aDItLLLsRFApptSFSsDs+GGG+ESNh+hlPahlphshaLLsp.......osstp..R..c....p+s..ltualo.s....sspphhps................shph.....-ss..ahhVhSLhs.pSh-pWpppRhsaLpRhltpuah...pah.pstsssch......................s.pspcp....aslh+PhLlaauLl-pl.phFKhth....................o.ssst-sW.hshpE+LppN.pthlsts+clLphh.-EhhsspDhpEhhDlsG	....................................M.tNPYsS.c..hGP.LMRDlKNKICpph-hluLl-DD..G.MELLVssp.Ilu.LDL.....slt.p..VYcplW.......................................................................................................................................h.p..tp..............................s.sMplhYRhpGL.G-ATE.hlc..pL.........ps.p.p.......pcp...c.E..athsssh.tpssGLphhlphlttlp.p.........................hpp.s..p..lth...l.....lcLh.hssKl.chspp.Lhp....hsslshhLtsh.phsh.stt...........st.sEplL.....................................lhE.lhtcus......tpsht...t.....h.t......................................................................s..p.l.hhlpphs...........ss..hhcps..ph..hptlhRllshLsaGp.ttMthLhphF....pshh.p....apphDt........................pp.p......cp.................p..hh..l-.Fshlstul.........p..p.ss...GtpLKshll.phGlh.ptuhp.YhtpphPsh....................................hph....s.us.hpphlp..pPuL.hlLphLpG..........Luh..t.H.s............TQ........hh...l......s..p..............p...l.s.lHtLEtVu.......u..p.......ptlGs..lAENLL.-sLpp.p.t.............................hspplpth....RctT+tEp+chAhthRpc.LttLGMph....sctG...pl...ssp.sshlpphcc.l.......-..EsGLs.ChlCREGYphpPschLGlYsFo.KRssltt......................hp..p...ptp.............................................................sYoTVoaFNllHhpCHhtAhR.....htps+cE.........W-uAsLpNspTtCNslhPlhG.P............p...Vstusassslsca.s.lpp.h..s........t..tpt.....php....h..aDltLLhhRFAht...tSFpsDstGGG.pSNh+hlPahl.hs.hal.lsp.....................ststtpp......tpt...l.s.alp.t..s..pt..ps................................................shp...-ss..ahhh.uLhh..s..cpWpt..+hthLp+hlhhu.h...pthts.....t.........................................tt.p...a.sh.h+s.Llahull-.l.phhhph........................................................................s.ssp.ttW...ht-hlt.ss..hhthscphlphh.--hhsspshtEhhDlhG..............................................................................................................................................................................................................................	0	62	81	111
+13607	PF13765	PRY		SPRY-associated domain	Coggill P	pcc	Jackhmmer:B0V264	Family	SPRY and PRY domains occur on PYRIN proteins. Their function is not known.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.77	0.72	-8.27	0.72	-4.43	191	3648	2011-02-02 16:53:56	2011-02-02 16:53:56	1	109	99	11	2020	2534	0	48.80	38	9.97	CHANGED	loLDPsTAaspLhLS-Dt+.pVph....sppt...p.shP..-sPcR.Fsph..spVLupcuF	......................lTLDPsTAaspLhL.S..-Dp+.pVph.................sppp...............p...shP....-sPc..R.Fsth..spVLuppuF...................	0	51	592	1270
+13608	PF13766	ECH_C		2-enoyl-CoA Hydratase C-terminal region	Coggill P	pcc	Jackhmmer:B9A058	Domain	This is the C-terminal region of enoyl-CoA hydratase.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.55	0.71	-3.95	180	1675	2012-10-02 13:07:06	2011-02-02 17:12:08	1	13	1322	3	662	1647	343	119.80	30	31.65	CHANGED	sL..ttptstI-chFu.....t....s..olpcIlssLcs.........c....s.s....p.....autpshcsl.ppt..SPhShplshc.lcc....u+..p.........h.o.lt-shphEhpluhpshp....p.........s........DFhEGVRAhlIDKD..+s...P.c.....Wp..sslp-..Vs.ss..hVsphFs	........................................tphshIsctFu........t....s..olp...cIlps...Lcp................................s...s.s....p.....aApp....shc.s....l.tpt..SPhSl.plohc...t.........lpc.....ucp.....................hoLt-shphEhplutphhp.....p.........s........D..FhE.....GVRAhL.....lDKD..ps........P..p.......Wps..sslp-..Vs.sp..VpthF......................	0	192	370	537
+13609	PF13767	DUF4168		Domain of unknown function (DUF4168)	Eberhardt R	re3	Jackhmmer:A3JZQ0	Family	\N	25.80	25.80	26.10	25.80	25.20	25.70	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.50	0.72	-3.35	72	184	2011-02-03 11:39:14	2011-02-03 11:39:14	1	3	138	0	75	191	5	81.90	23	54.79	CHANGED	hocpplppaApAhlplpslcpchhpc.lps..................sps...................p.pphppl...tpcAppph..............l.........p......tl.cssGLolppaNpIsptspsDs..pLpp+l	.........................................ospplppaApAhhplptlppphhpc.lpp........................sps....................................t.sphppl.......tpcuppph..............s.........phl.pssGLo...lpcaNpIsptsQsDs..pLpp+l......	0	26	61	70
+13610	PF13768	VWA_3		von Willebrand factor type A domain	Coggill P	pcc	Jackhmmer:Q3UR50	Domain	\N	27.00	5.20	27.00	5.70	26.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.94	0.71	-4.53	14	1260	2012-10-10 16:07:06	2011-02-03 14:36:20	1	77	395	0	741	6397	466	152.20	22	18.63	CHANGED	tclVlllDsSss.hpsp.....hhppulshhlcs..Lsspc.plsllshGs..ps..hh.ss....hhshssttlpthhthlps...hps..hGusslhsuLc...tsh....p...t........ttsthhcpllllo.cGs...t..ss....tcs..p.lp.p.t...tc..hphhshuh...ss..phs.s..shLptLAphupGthph	..........................................................................................t.cllhll.DtSuS.M.........p.......u.................hphs...+.......p..s.......l...h...h.....h.....l....cs.............L.......s...................p.......s.......p......F........N.........l..l..s..F......us..........p.h...p...t.h.....h.....s.p................................h..t...h......s....p....p...s....h..p..p...A..h.p...h.lpp................lps....hG.....u...T....p......l....h.....p.....s.L.p............tsh.........p......h...............................ttt...s.p...t....l.h.l..l.T..DGp.....sp......sp.......................p.p..l..h.....ph...l....p...p...tt..................tp.........h+..l..a..o...hul..................Gp............sss...t..........thlp...tlAphst.Ghh.....................................................................................................................................	0	248	375	539
+13611	PF13769	Virulence_fact		Virulence factor	Eberhardt R	re3	Jackhmmer:A3K275	Family	This domain is found in conserved virulence factors [1]. It is often found in association with Pfam:PF02985 and Pfam:PF08712.	25.00	25.00	25.60	32.20	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.60	0.72	-4.12	53	419	2011-09-19 00:13:31	2011-02-03 14:42:30	1	9	419	0	60	256	220	81.70	45	25.41	CHANGED	lha+sIPhQVhlspGcc....ps.+htLP-RFppAls+As....ttssDshlt-h+hs-..sst.G-hp.-lAcssspcl-AsYsp-RLcpLl	....hF+sIPhQlKLTsucp....Eh.RhtLPppFh-shspA.....tpssDNlVh.RKWl-..usRYGshE.ElhcsVlEEllAsYsEppLshLV.......	0	15	36	46
+13612	PF13770	DUF4169		Domain of unknown function (DUF4169)	Eberhardt R	re3	Jackhmmer:A3K2D0	Family	\N	25.00	25.00	32.60	32.50	18.60	17.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.72	0.72	-4.03	82	226	2011-02-03 15:43:01	2011-02-03 15:43:01	1	1	226	0	73	181	5	54.80	44	82.85	CHANGED	u-llNLpphRKp+sRsp+ctpA-pNRspFGRTKAE+phscscsc+spcpLDu+.+h	..u-lVNLRphRKp+uRsp+cppA-pNRlpFGRTKsEKshscspsp+Ap+hLDtpRh..	0	19	42	52
+13613	PF13771	zf-HC5HC2H		PHD-like zinc-binding domain	Coggill P	pcc	Jackhmmer:Q5W0A5	Domain	The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains.  The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.10	0.72	-10.92	0.72	-3.84	144	1247	2012-10-03 17:27:21	2011-02-03 15:57:56	1	127	218	0	775	2477	15	83.60	31	6.32	CHANGED	HhhCuLassplh.ps.stt........slpsl.pphsppthphpCth..Cc........pp.....G.AslpCsttsCppsaHhsCAtpss.hhhp......hp.................t...........................phpsaCppHs	....................................HhtC.hl...aS.stlh.pptst...................t.lt.sl..cp..tlp...c..upph.....cCs.h...Cp.........................ch........G..Aol.u.........Cs....t.p..sCp...psaHhs........CAhp.s...t...sh.hp.........tp....................................................hphhC.pHp.........................................................................	0	191	283	499
+13614	PF13772	AIG2_2		AIG2-like family	Coggill P	pcc	Jackhmmer:B3KMN7	Family	This family is found in bacteria and metazoa.	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.77	0.72	-3.87	26	714	2012-10-02 16:39:48	2011-02-03 16:07:47	1	11	571	11	289	659	306	83.90	29	41.81	CHANGED	cVaGsLaclshpshpsLDppEuVp...pGhYh.lplpV.....ps...pss.pp.lhsRsYhlss...p...ss....s....................PSppYLplllcGAhpsGlPpcYlctL	...................................................................pVaGlLacl.s........p..........-hpsLDphE.G.s.........hthYp.+.hp.lp.V...................ps....tsG.p...l..Ahs.Ylhs.s....h.......ps.....uh...........................P.SspY...Lshl...hc.G...Acps....GhPpcYlp.L...........................	0	97	180	239
+13615	PF13773	DUF4170		Domain of unknown function (DUF4170)	Eberhardt R	re3	Jackhmmer:A3K3X5	Family	\N	25.00	25.00	26.40	25.60	21.10	24.50	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.24	0.72	-4.07	34	216	2011-02-03 16:14:24	2011-02-03 16:14:24	1	3	213	0	76	162	34	68.60	62	81.17	CHANGED	pQLLHLVhGGELp..c..hss.spF+DLscl-lVGlFPsYssAhsAWKucAQpTVDNAcMRYFIlHlHRLLDPs	.....pQLLHLVFGGELp..c..Lss.spF+DLpslDIVGIaPDYtSApsAWKuKAQpTVDNAHMRYFIVHLHRLLDPp......	0	20	45	55
+13616	PF13774	Longin		Regulated-SNARE-like domain	Coggill P	pcc	Jackhmmer:C9J9A4	Domain	Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex [1]. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterised by a conserved N-terminal domain with a profilin-like fold called a longin domain [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.97	0.72	-4.43	180	1355	2011-02-03 16:49:18	2011-02-03 16:49:18	1	14	344	17	898	1268	11	84.60	23	37.83	CHANGED	hu+.pllp+ls.......ss...s...+tohp.pss.ahhHalh...p......su.................lsalsls-c.sa.s++lAFsaLp-lpc-Fhp............pas..........t.phtsss...sauh.......hpFssh	....................................uctlhp+ls.......ps.....................s+hohp..pss...ahh..H...ahs....p.................su........................lsalsls.-c..sa..scclAFsaLpcltc-Fhp...............pas..........p..phtss.....shsh....pFs..............................................	0	294	502	724
+13617	PF13775	DUF4171		Domain of unknown function (DUF4171)	Coggill P	pcc	Jackhmmer:B0QXZ9	Domain	This short family is frequently found at the N-terminus of Homeobox proteins.	27.00	27.00	36.40	36.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.73	0.71	-3.96	4	63	2011-02-03 17:52:59	2011-02-03 17:52:59	1	2	34	0	25	53	0	128.00	76	23.90	CHANGED	DTAMDLLKAITSPLAsGS........KPSKhhup.ssuSSspScS+KE............HH+KhGsuSo......DssSH+SKK.h.hasss...EsLTLREPDGLKMKLILSPKEKu..........pSSssppuhth.uppAosKKsSKKpuR-Ept	DTAMDLLKAITSPLAAGS........KPSKKTGEKS.Su.S....S....S......HSESKKE.............HHRKKlSGSSGEL...sLEDGuSHKSKKMKPLYVNT...ETLTLREPDGLKMKLILSPKEKG..........SSSVDEEuFQYPSQQATVKKSSKKSARDEQG................................................................................	0	2	4	10
+13618	PF13776	DUF4172		Domain of unknown function (DUF4172)	Eberhardt R	re3	Jackhmmer:A3K4N3	Family	The family is often found in association with Pfam:PF02661.	25.00	25.00	27.10	25.80	23.90	23.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.45	0.72	-3.88	93	374	2011-02-04 09:14:32	2011-02-04 09:14:32	1	4	341	0	117	349	80	79.70	41	22.14	CHANGED	aIWQpscWPpFpWDsppltshLppsphpQGtLlGph..pslu.s.pppstL-sLsp-llcoStIEGEpLstpSVRSSlAR+LGl	.........aIWQpscWP........pFpWDtstltshLppsphppGhLlGch......psls.stppptsL.-sLhpsllpS..StIEGEtLNhtSVRSSlAR+LGl........	0	29	64	91
+13619	PF13777	DUF4173		Domain of unknown function (DUF4173)	Eberhardt R	re3	Jackhmmer:A3K0W3	Family	This domain of unknown function contains multiple predicted transmembrane domains.	24.10	24.10	24.40	24.40	23.60	23.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.45	0.71	-5.01	54	229	2012-10-01 23:40:40	2011-02-04 09:19:05	1	2	227	0	76	246	7	185.70	26	36.61	CHANGED	LsllslLahlasslQlshLa..GG...ssl...ss.GhoYA-YA+pGFapLlhsslLshlhlll....s...pth....hp.....c......sp.....l.l.+sLlhlhsshslllluSAhhRhpLYlssYGLThhRlhshhahhhlul....slllllhplh...tthsstalhptsh.hssssslh.shuhhN.-shIAchNls+..t.....pssplDhpYLs.s..Lu..scAhPultch.	....................................hhlshlahhFshlQhshLa..uu......tth...ss.uh.oY..u.pYA+pGFapLlhlslLshsllhs....s.....phh....sp.....c......p+.....h.l.+hlhsll.sshoh.lllhSAhhRh.slYlptYGhThhRlhshhahhhlsl.hhllllhplh....+th.....tthh........hpt.sh.hs.shsshh.hhshh........s.-thlAphNlpp.....................thtthDh..Ylt.t..Lu...sAhshl....h..................................	0	32	57	66
+13620	PF13778	DUF4174		Domain of unknown function (DUF4174)	Eberhardt R	re3	Jackhmmer:A3JZK5	Family	This domain of unknown function is found in a putative tumour suppressor gene [1] and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion [2,3].	27.00	27.00	32.10	33.70	25.30	26.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.38	0.71	-4.00	85	508	2012-10-03 14:45:55	2011-02-04 15:36:30	1	7	241	0	222	467	183	122.10	31	45.45	CHANGED	ssLspatWppRslllFAssssDsphppQhphLpp..pt...ssLs-RDllllss.sssssps...........................sLRpphc....sps...FthlLlGKDGthKlR....tstPh.sscclhcsIDpMPhRppEh	.........................LspFth+pRlLlloAPsssshhap.QhshLpp..st...CslstR+lsllpl.hssssppss.....................p.hss.th..h.pLRphhpls.....pt...FshlLlsKDGpsKpc....astPl.shptlashIDshPhRppEh.....................	0	17	53	116
+13621	PF13779	DUF4175		Domain of unknown function (DUF4175)	Eberhardt R	re3	Jackhmmer:A3K2P3	Family	\N	26.40	26.40	26.60	26.70	26.00	26.30	hmmbuild  -o /dev/null HMM SEED	820	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.60	0.70	-13.46	0.70	-6.84	55	303	2011-02-08 14:41:21	2011-02-08 14:41:21	1	2	262	0	113	278	125	681.10	30	90.41	CHANGED	ERlh.shWPlhollhlhLuhshhGLaphlssthhhss.lsl....hsluhl.suLhhslh+aRhPsRsEALsRLDt.s.......LstRPlsALtDs.AhGssDssutALWpsHQpRMAsphuph+ushPc.+luc+DPaALRhlAlLhlls.A..hha..u...u..h...hRluslsshhsu.sus..s..u.s.usph-uWlpPPsYTGcPslaL..............s...sts...............ss...........slsVPpGSplolRhhG..........t.su...slsls..........ps.sos..p.s.............ss.ssss...........................s...........sp.......pcFs..lsp.sGslslp..usu.....uc....sWplsllPDpsPpIshss.sPct.sspGshplsapAcDDYGVssucApIs.hsh....s.sssc..p.Ghssc......P.........hhcs.plsLsLPhsusRsshstthlcDLocHPWAsh.VplTLsApDuAGQpGpSpshphhLPuRpFhcPLAtAlIEQRRsLhhstssss.cVsplLcAlohpPEc.hhtstssYLtLRshhpRL-......tu......ho--shc-lsstLW-lAltlEDGsLusAcc+LRcAQ-+LpEAlcpGASD.EEIscLMpELRcAhp-Yh+pLAcptppssp..pt..tps....p....ssp...phoQpDLpcMhDRIpELhcpGchspApphLcpLQpMMENhQssQ.....sQ...t..........ts...p.u.ttp...QuM-pLu-hlRcQQpLpDcsFRphQ-.p...p.....s.......QpGp........p.pspp.sp.............s.pt.Gp...s.Qt.................sp...pttp....sp....stp..........psppsp.........tt......p....p..ttps..............LuccQpsLp.ccLpct.p.ppLsstGsp.uttup-uLscAscAMcsApcALtcGchspAlDpQucAh-ALRcGhcsLuEtM.....tpp..........ptpt....pGt....tspt....t.Gp.....ts..s..pspDPLGRstssp.G..ssss.psh.lssE.shpRAR-lL-ElRRR.G-ssRPplEhDYLcRLLc	............................................................................................ERhh.hhh.hhhllslhhuhuhhGlhthhP...hh....phhhlsh.hshshl.hsl...hsh.p.h.R....Pppt-h...tRl..-..t.ss.....tLsppPlss.p...Dp.A...ss...tcsh....u......A.LWptHppRhttpltplpss.....h..P.c..c.hstpDPauL.Rh.hshlhhls.A..hhh...u.......s.t....tRhupshs.h.ssts......h......ssp..l-.uWlsPPtYTGpsPlaL.....................s...sts...................ts...........slslPtGShl..s..lRhh.G..........tss...thshs......ts..st...t..............t....stt...............................................................s...hp.....hph..p..lpp.stsltlp..u.s...st........pWphsshPDpsPplthst...tP...c...t.....t...h..p.G.p.hpLs..aphpDDYGlsp.upuplh.............s..............t....p......P................hts.phsLsLPhtsscps....h.........pDLopcPaAG..VtlsLsspDsAGppGp.Stsh.hhLPtR.F.pPlAtAlhEpR+.Lshstppt..pshphLpAlh.htP-t.hh.s.shaLtLtshhppLp...............hu...hscp..thppssshhWplAltlE.....p.....G..s.....lu..tApcp..LRtAQptLppAl...p..........p..........s.....A......u...p........pEItcLht...-LRpAhpcahpt.hApp.tpssp.t.....t........tst..hppp-LppMhcplpphhcpGptstApphLp....plpphhpNhp...hsp............sp..p........................ttpsphp...pthp...pLs-hh+cQQphhscoa.pt.pp.php...t............p.st........p..ttt.t....................................tt............................................t.......t....t.....t.............tt.....th.....t....p....t.pp...............................htppQptlp...ppLp.p....pt..h.t.thp..............stps.....hscAtpuMtsAtpALt.p..sp..hstA.stQupAl-uLRcGtpphhptM.....tpt..................................ttt.....t..........stt....t.s......................tttttpDPLGR......t...sp.s...t..sp.psh.lssc..shpRARcIL-ElRR+.upt.pPp.EhcYLpRLLc........................................................................	0	35	71	88
+13622	PF13780	DUF4176		Domain of unknown function (DUF4176)	Eberhardt R	re3	Jackhmmer:D3E5E1	Family	\N	25.00	25.00	25.10	25.30	23.20	24.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.60	0.72	-4.26	56	651	2011-02-08 14:46:40	2011-02-08 14:46:40	1	3	430	0	56	331	1	72.40	40	70.15	CHANGED	lLPlGSVVhLKs..usp+...lMIluRt.hh....psppp...haDYsushYPpGhhs..-pshhFNc-DIpcVlFpGYpD--Ehpat	..............slGSllhLcp....sp.pp...............lMIlsRt.lh....pspph.............haDYsushYPhGhlp..-plhaFNc-sIcpVlFcGYpDp-EhpF..............	0	17	34	45
+13623	PF13781	DoxX_3		DoxX-like family	Eberhardt R	re3	Jackhmmer:D3E5H6	Family	This family of uncharacterised proteins are related to DoxX Pfam:PF07681.	25.00	25.00	25.40	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.10	0.72	-3.66	76	297	2012-10-02 13:32:46	2011-02-08 15:41:34	1	3	292	0	87	289	15	100.70	27	34.60	CHANGED	uhlWlhsGllshhlhs.st.phplLsph.Ghssthushhlhhsu.l.h.-lshGlhhlh.thpp.+.hshhhpl.h.ll.luhhlhsshhhPphahcPasPlsKNlsllsLth	...........................shlWlapGllsth.....lhstst.phplLsth.shss..thu...hh..hlhhsuh.h-lhhGlhhLh...hhpt....+.thhhhplh.ll.luholssu.hhtPthahcPFsPlstNlslhsls...........................	0	21	41	65
+13624	PF13782	SpoVAB		Stage V sporulation protein AB	Eberhardt R	re3	Jackhmmer:D3E7E2	Family	This family of proteins is required for sporulation [1].	25.00	25.00	27.10	26.10	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.34	0.72	-4.08	43	225	2011-02-08 15:45:58	2011-02-08 15:45:58	1	1	225	0	34	157	7	103.60	50	80.58	CHANGED	lssLGllPRhuplT+TtcplhhYEsslllGullGshhsla.chpl.h.....ut.hllslhGLhuGIFlGslAsALsElLNVhPIhuRRlplpptlshllhulAhGKslGSLhaahh	....lslLGllPRLsplT+ohcpl.haEhullhGslhGshhslh.phsh.h.....................up.ahLlllGlFsGhFlGMLAAALTEVLNVLPILAKRlGlc.spIllLLhAlVLGKllGSLFaWl...........	0	10	24	26
+13625	PF13783	DUF4177		Domain of unknown function (DUF4177)	Eberhardt R	re3	Jackhmmer:D3E8A6	Family	\N	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.10	0.72	-4.34	50	606	2011-02-08 15:50:16	2011-02-08 15:50:16	1	2	570	0	167	416	98	52.20	41	82.95	CHANGED	paEYcsltl.ht.tts.......tphcplLspaGp-GWELVpllss.......t.t..t..shhshhKRp	................................pWEYtT.lPlhs..+uo.................cp.......ILspaGpDGWELV.pllsu...................st.-phluYhKR.............................	0	58	133	159
+13626	PF13784	Fic_N		Fic/DOC family N-terminal	Eberhardt R	re3	Jackhmmer:A3K4Q6	Family	This domain is found at the N-terminus of the Fic/DOC family, Pfam:PF02661.	25.00	25.00	25.00	25.50	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.70	0.72	-4.12	115	562	2011-02-10 11:07:32	2011-02-10 11:07:32	1	9	506	2	173	510	92	83.30	34	23.18	CHANGED	llphlspAspALucLcuhsphlP.Nsslll..sshshpEAhhSSpIEGT.oTh--lhph-tsts.s........tss-scEVhNYhpALptGhcp	..................................hptlhpAptuLucLcuhuphlP.N.s..lLl....sslshpEAhtSScIEsh.hoThD-Lhphptptst...............ssss+EVhsYtsALptGhc.............	0	67	135	157
+13627	PF13785	DUF4178		Domain of unknown function (DUF4178)	Eberhardt R	re3	Jackhmmer:D3E9P9	Family	\N	25.00	25.00	25.00	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.82	0.71	-4.19	54	460	2011-02-10 11:12:14	2011-02-10 11:12:14	1	3	375	0	119	366	29	142.20	22	59.83	CHANGED	LtsGDhlph.....s.ut..sahV..pGphp.....h..p.pushpWtEahLp..s.sspttWLslE........--splphslhpphsshs...............sssplph....-GppaphsEpGsAp...hpupussshtsu....sphpah-Y..tusss.phLuhEtass........ph-hspGphlsst-	.............................................Lt.Gshsph..........s.sh..papl..hGphp....................h.......p...ps..t..tWh..EahLp..s..spshtaLplE........-cs.ph...thplhsthssht........................................psssphph.........csp.p.Yph.p-p.....hpup.....sssp.spt.s..h..tsu.......pphphh-a....pusst..thLshEh.ss...................ph.h.pGc.l....t..................................	0	36	62	96
+13628	PF13786	DUF4179		Domain of unknown function (DUF4179)	Eberhardt R	re3	Jackhmmer:D3EAG2	Family	\N	25.20	25.20	25.20	25.20	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.04	0.72	-3.76	49	573	2011-02-10 11:15:32	2011-02-10 11:15:32	1	7	242	1	126	525	5	99.40	20	25.09	CHANGED	p+h.cp...+p....htp.tth....sh..s...sslh....lh.....l...hs....o......ssaAt.h........ts....l.hph..h.p..p....pGhpp..sh.pptaupt..lsp....oho.spGlplTlscllhDcsplhlhYplc.spc	....................h...pp....+t....hhhpts........su..s....uslh.......lh........h....hs.........s...........sshA.ssls................hhss.....lhph...h.s..tc.............pG.lpp.............sh.pt..th.s..pt...l..sp................ohp..spGlslTls-lhhDs.splsltYplcpt.............	0	57	114	117
+13629	PF13787	HXXEE		Protein of unknown function with HXXEE motif	Eberhardt R	re3	Jackhmmer:D3EB69	Family	This domain contains an HXXEE motif, another conserved histidine and a YXPG motif. Its function is unknown.	25.00	25.00	26.40	26.40	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.71	0.71	-3.72	142	380	2011-02-10 11:30:58	2011-02-10 11:30:58	1	2	312	0	94	360	151	114.00	21	63.39	CHANGED	halh.llahlH.phEEhhh....h.tahspph.th.....................hhosptFhlslhhhhlhhllhshlsth...........hhhhhhlhh..hhphl.hHlh.s.hhh+p..YsPGlloulllhlPhulahh	....................................hlh.hhahlH.phEEhhh........h..a.hpp...th.th......................hhsspshhlslhhtallhhlhshhshh.t.........hhhhhhhta...hhphl..hHlh.....s....hhh+p..........YsPGlhTullh.lPhulhh..............	0	33	66	78
+13630	PF13788	DUF4180		Domain of unknown function (DUF4180)	Eberhardt R	re3	Jackhmmer:D3EBG4	Family	\N	25.00	25.00	36.20	36.10	23.70	22.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.34	0.71	-4.43	45	213	2011-02-10 11:34:24	2011-02-10 11:34:24	1	3	206	0	58	178	5	109.50	43	79.20	CHANGED	hc.psshplshlsucssllsstp-ALD.Lluss.aptssstlhlstspls--FFsL+TtlAG-ILQKFlNYcl+lAllGDhSta..sSpuL+DFlaESN+GpplaFlssh-pAlp+L	............h...sshplshlpsspslIsssQsALD.hhuss.aEtsscplllpcshloEDFF-L+TpLAG-ILQKFlNY+lKlAIV.GDFShY..sS+uL+DFIaEsN+GpclaalsocppAlc+L..........	0	25	48	56
+13631	PF13789	DUF4181		Domain of unknown function (DUF4181)	Eberhardt R	re3	Jackhmmer:D3EC26	Family	\N	25.40	25.40	25.40	25.40	24.90	25.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.20	0.72	-10.65	0.72	-4.13	31	197	2011-02-10 11:38:06	2011-02-10 11:38:06	1	1	123	0	28	151	0	94.60	34	86.50	CHANGED	lhhhhh-phl+KKL....sltKpthh...caVNphHchlEhhl..hllhllsh..hhhhhh.c........h.hthhhhhahslhhshRuaMEWKY.s+-oKc...Yllolhthh...hlllhuhhhhhh	.................hhhp.hlR++L....sh.K..ptha...caVNphHhhhphhl..hhhalls...hhhh...p........h.h.thlhhhahhhhhshcu.aMEWKY.D+ESKEYllSlhshh...hllhhullhhh.......	0	3	24	25
+13632	PF13790	DUF4182		Domain of unknown function (DUF4182)	Eberhardt R	re3	Jackhmmer:D3EDS0	Family	This protein of unknown function contains a number of highly conserved cysteine residues, which may form disulphide bonds.	26.00	26.00	35.60	35.40	25.90	25.20	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.01	0.72	-4.16	13	277	2011-02-10 11:50:17	2011-02-10 11:50:17	1	1	126	0	21	82	0	38.50	73	89.38	CHANGED	MGTIVCQsCssTIsaFE-EKVTsLYGpCsp.C-Ccppcc	..MGTIVCQsCEGTIuHF.E.D.EKsTVLYGKCGo.CcCc+cEc........	0	3	12	14
+13633	PF13791	Sigma_reg_C		Sigma factor regulator C-terminal	Eberhardt R	re3	Jackhmmer:D3EDV4	Family	This family is the C-terminal domain of a sigma factor regulator, this may represent a sensory domain [1].	25.00	25.00	25.80	27.10	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.76	0.71	-4.18	37	457	2011-02-10 11:53:04	2011-02-10 11:53:04	1	6	316	0	49	336	1	146.30	29	45.71	CHANGED	plpclspsplsEsulSFD+sYohcE..lpphhspt..........sWhhlcTts-ppppt.t........................ttpshGat....spt.ph....tpp.tp...cpFl....stLchhscppphsphhs............hppphchlpp.pslclhGlllTGpsc-ltpLtspshl+uuslGss	...................................Lpch..pspVsEVAlSFDKsYohpE..lpphlPsshp........lWhh..lsotpc.pcpps.t....................................sttshGFt.........ph.p....p..........t.....p..p..pp...ppFh........ctLc.phspp.pct....p..t.p.............................htpphc....hcp..pslclaGlllTGpocphppLpspsal+uAslGsh.................................	0	8	27	38
+13634	PF13792	Sulfate_tra_GLY		Sulfate transporter N-terminal domain with GLY motif	Coggill P	pcc	Jackhmmer:C9JKR6	Domain	This domain is found usually at the N-terminus of sulfate-transporter proteins. It carries a highly conserved GLY sequence motif, but the function of the domain is not known.	25.90	25.90	26.80	26.80	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.49	0.72	-4.31	377	6864	2012-10-03 01:44:59	2011-02-10 11:55:28	1	50	2950	0	2486	5940	1281	81.00	30	13.90	CHANGED	lP...hl..p.....W......l.p....Ys....p.hl.tsDllAG....lTluhhhlPQulAYA.h.lAG..lP..P.hGLYuuhlssllYulaGoS+plslGPsA.s.h.o.l.l.l.us.s.l	........................h.t........hp.......p.ph...ttDll...AG.................lsVullh.lP..............u........lAa......A..l..luG.........ls...........PhhG...L...Yuuhls.sl....lhu.lhGuSp..thls...........G.Psuuh.ulllssh.h...................................	0	663	1334	2000
+13635	PF13793	Pribosyltran_N		N-terminal domain of ribose phosphate pyrophosphokinase	Coggill P	pcc	Jackhmmer:C9JDH0	Domain	This family is frequently found N-terminal to the Pribosyltran, Pfam:PF00156.	25.00	25.00	25.10	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.32	0.71	-4.35	429	6720	2011-02-10 13:49:44	2011-02-10 13:49:44	1	18	4765	46	1992	4453	2459	117.60	47	35.76	CHANGED	lplFoGsus....pLAccIuctL.........................Gl...Lu..p.......splp+FuDG..........EltVpl..........pE....oVR..GpDVFllQoT.s..........s..............P.lN-sLMELLlhlDAh+RASA.p+ITAVlPYaGYARQDR...................K.sps........RsP.........IoAKL.......VAsllpsAG	..............................................................................h+lFuusus....pL.Ap.cl.App...L....................................................ul..t..LGc......sslp+FSDG..........ElpVpI...............pE.....oV.R....G.p...D.V........FllQST.s....s..............................................P.sNDsL.MELLIMlDAh+R....A.SA..pp..I....o......sV..l..P....YaGYARQ.DR...............................+..s+u........RtP.........IoAK.L.......VAshLpsAG...................................................................................................	0	654	1213	1657
+13636	PF13794	MiaE_2		tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	Coggill P	pcc	Jackhmmer:A0JYP2	Family	\N	21.50	21.50	21.50	21.80	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.07	0.71	-4.80	3	288	2012-10-01 21:25:29	2011-02-10 15:50:20	1	1	287	4	74	200	13	176.30	42	79.12	CHANGED	sRYccuVVDLLGALAYGELSAFERLAEDARhAPTLsDRAsLA+MAuAEF+HYEhLcDRLAuhGl-sE-AMcPFVAAaDsFHupTcPuDWLESLVKAYVGDolAADFYREVAcaLDsuTRELVLsVLDDTGHouFAcE+VRAAlAuDPRLuuRLALWGRRLLGEALTQAQRVVAERDALuoLIlGG	................................................................t.......h.cLhuhl...AYuElu.AF.RLsc-.u.chAPsLssR...ht...lAsMAuAEh.t.H.act.LRstLsc.R.Gs-s..htAM.pP.asuu.l-sa+t...T......s..P...psW...hEu........LVK.sYVuDuLAuDFYpclAssL...s.sp.s+sl.Vt.u....s....L....s.-..TGpupFss....ucVRuAls...A.c.sp.+uRLuLWuRRLlGEAlopAQhlh.Ac+ppLsshlh..s........................................	1	24	59	71
+13637	PF13795	HupE_UreJ_2		HupE / UreJ protein	Eberhardt R	re3	Jackhmmer:A3K636	Family	These proteins contain many conserved histidines that may be involved in nickel binding.	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-10.78	0.71	-4.73	99	405	2012-10-02 18:22:22	2011-02-11 10:42:20	1	4	310	0	155	468	1125	151.10	36	51.33	CHANGED	alhlGhcHll..pGhDHlLFlluLlh........................hhtph+cllhhVTuFTluHSlTLslusLshls.....ls...ut...llE..slIulSIlhtAl-Nl...............hhshh.thphhhshhFGLlHGhGFAshLp.phslspss..hlhsLLuFNlGVElGQlhllshlLhlhhhhpcth	....................................alhlGhcHll..pGhDHlLFLlu..llh.............................hhtph+c.llhhVTh.F.TluHSlTLhl.ushshl.s............ls...sh...llEslIulSIlahA.l-Nl....................thht.ht.tphhsshhFG..LlHGhGFAshLt..-.h..s...ls..p...s..........s..l.lhsLluFNlGVElGQlhhlshlLhlhhhhpp.h.............................................	0	58	109	136
+13638	PF13796	Sensor		Putative sensor	Eberhardt R	re3	Jackhmmer:D3EFN7	Family	This family is often found at the N-terminus of proteins containing Pfam:PF07730 and Pfam:PF02518. The N-termini of proteins containing these two domains often function in stimulus sensing.	26.00	26.00	26.60	26.50	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.60	0.71	-4.67	87	465	2011-02-11 10:52:36	2011-02-11 10:52:36	1	7	224	0	205	504	14	172.20	21	46.00	CHANGED	allhuhshulsshshlhss.lslus.slslhhl..G.lslLssslhss+shuthERtt.spthh..sh.plstP........st......suhhstltshlp.-suoWRslhahll.phsluhlshhlsssh..hshulshl..shPLhhhhhsss.hs.hh.............hhlsohspuls..hsh...l.Gllhl.hlsha..ls.sslsp....hpuhhs+uLL	.....................................allhshshulhh.hs.hhlsh.lshuh..slsh.hhl.G..lPlL.s.h.slh.ssRs.huphERtp.scthh.......uh.pl.st.s..........tt............................suhhtp..lt.thLp.DssoWRslhahhl...phsluhlshhlslsh.hshs.lh..hl......hh....Plhhhhhs........h......................................h.lsshstshh.hhh....h.Gllhh.hhshhls.tshsthpshhspthL.................................................	0	68	162	199
+13639	PF13797	Post_transc_reg		Post-transcriptional regulator	Eberhardt R	re3	Jackhmmer:D3EKT1	Family	This family includes post-transcriptional regulators [1].	25.00	25.00	30.60	30.50	21.80	21.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-9.57	0.72	-4.39	26	293	2011-02-11 10:56:17	2011-02-11 10:56:17	1	1	293	0	38	158	1	86.50	35	87.77	CHANGED	phcta+cp.lpPsLpsKh-EF+hLGYcplot-clWsaLhp+KWK+ppt...hpLaEllsDIhslphs-YMsahTlcuhcssshhhsctspc	..........h..p.hppp.LpsslcpKsEEF+hhGYcplsp-DlWpaLpscKWK+tss...lpLaEhlsDlhplpssEaMsYlslpAhpus...hsph-....................	0	15	28	30
+13640	PF13798	PCYCGC		Protein of unknown function with PCYCGC motif	Eberhardt R	re3	Jackhmmer:D3ELL0	Family	This domain contains a PCYCGC motif and four other conserved cysteines. Its function is unknown.	25.00	25.00	30.10	26.80	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.17	0.71	-4.54	13	157	2011-02-11 11:09:16	2011-02-11 11:09:16	1	2	138	0	31	109	15	151.10	54	89.50	CHANGED	hh.hllshullLuGCussssp-pspscp...........pppssGDIpEpTuSs-pLPoFLcs.ps-slpplYptuupppELL-aIPCYCGCGESAGH+sNhsCFlpEp+cDGslVWDDHGT+CGVCLEIAspShphhpcGKShK-IRphIDEpYKEGYAKPTPTPMP	............................lhu..hlsllSllLuGCGususs-..p.....psucp.pppt.......pto+oppuD.IQEcT..KulDsLPoFL-c...h-spM+cIYslAGpssELL-aIPCYCGC..G.E.SsGHKNN+NCFI+EIKKNGc.V.V.WDoHATsCssCLEIAVESuuM+QcG.K.S.shEIRsaIDsKYKEG.YuKPTPTPMP...........	0	9	22	25
+13641	PF13799	DUF4183		Domain of unknown function (DUF4183)	Eberhardt R	re3	Jackhmmer:D3EMB4	Family	This domain of unknown function contains a highly conserved ING motif.	25.00	25.00	25.10	36.50	24.70	22.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.89	0.72	-4.17	22	220	2011-02-11 11:15:06	2011-02-11 11:15:06	1	6	107	0	31	144	6	77.60	40	52.48	CHANGED	sssh+ahaTss-clthhustsIsust...................suYhNLaINGVLQ.tshY.sls...sutLsLpssss..htGsPIllph	.................h.suc+hh.TsusGhuthushsIsussh...................hoYhNLaINGlLQssshh.sVo.......TGslTls........ssss..lssGoPIhlEF..	0	11	21	21
+13642	PF13800	Sigma_reg_N		Sigma factor regulator N-terminal	Coggill P, Eberhardt R	re3	Jackhmmer:O07581	Family	This domain is found near the N-terminus of a sigma factor regulator. The N-terminus is responsible for interaction with the sigma factor [1].	25.00	25.00	25.00	25.70	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.22	0.72	-3.96	22	353	2011-02-11 14:42:16	2011-02-11 14:42:16	1	4	247	0	37	251	0	91.50	25	27.43	CHANGED	.Kphl++uKhKthlp.h.llslhl.hlllhhhhhhhshl.ah.sp....spch.hpshphhhplopPNshlssp.hp.sphs.hFutshph.sl.KplGscsl.	..........h.ct.h++uK+Kphlphh..llslsh.sllllshhh..h.shhha..sp.....phpcl.p-hhshthplst.PNsphsup..ht.sssp.hFusphph.shhKslsshsl..................	0	6	20	28
+13643	PF13801	Metal_resist		Heavy-metal resistance	Eberhardt R	re3	Jackhmmer:A3K6W9	Family	This is a metal-binding protein which is involved in resistance to heavy-metal ions [1,2]. The protein forms a four-helix hooked hairpin, consisting of two long alpha helices each flanked by a shorter alpha helix. It binds a metal ion in a type-2 like centre [3]. It contains two copies of an LTXXQ motif.	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.29	0.71	-4.14	97	966	2012-10-02 12:34:46	2011-02-14 13:53:14	1	3	826	26	248	1113	79	123.10	29	76.98	CHANGED	sSLslNlhllGslsusshph.ssttstt................thht.hhtsLsscppctlppthcstt.t...phpshppph.cpttpplhphltApshDssslpsslsptpptptphppthppthlshhsshss...cpRtt	...............................................................................................th.......hhhul..uhuhss.ss.uhspsup.............................shhp..ps..s..s..sL.....T..sEQpst...h...pclhs-ah..s........ps...s...u.L.....p.....p.....p.......l..hscR........hE.h....s....A....LL.s.As.ssDsu..c.lsAlsc-hcslpppLcchp.lcpslshspshhPct...st.....................................	1	81	156	203
+13644	PF13802	Gal_mutarotas_2		Galactose mutarotase-like	Coggill P	pcc	Jackhmmer:Q8FC64	Domain	This family is found N-terminal to glycosyl-hydrolase domains, and appears to be similar to the galactose mutarotase superfamily.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.35	0.72	-4.12	218	2671	2012-10-02 23:57:29	2011-02-14 13:55:17	1	55	1668	60	985	2314	64	65.70	31	7.77	CHANGED	sEphYGlGE.+.s.....s.sls....++.....G................pphch...aNt....Ds..hsh.p..ps.......csh.....YpsIPFhlshp.......ss..p.......u.aGlFasNstcshaD	....................EplYGLGE.+..h.....s..sls....+p........G.............................pshch.....aNp...Ds....hs..p...ss....................pth..........YtslPFhh.................ss....p..............u..a....Glahssstps.h...............................	0	358	606	839
+13645	PF13803	DUF4184		Domain of unknown function (DUF4184)	Eberhardt R	re3	Jackhmmer:D3EE91	Family	This domain of unknown function contains several highly conserved histidines.	25.00	25.00	25.20	74.50	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.81	0.70	-5.06	38	172	2012-10-01 21:01:47	2011-02-14 14:10:33	1	1	170	0	22	182	3	235.70	41	94.91	CHANGED	MPFThSHPAhllPlp+hsh....LshsALllGSMsPDh.YF.....hthp.......tsshuHshhGlhhhsLPlslllhhlaphll+psLhphlPh.hp.phhs.hp.....hh.hcph.l....lhlhShllGshTHllWDuFTHpsGa.hVpthshLpppl..thhs..tlPla+lLQauSollGllhlhhhhh+hhpppspp.t..h......ptKhhhhhhlh...lhuhlhhhhhhhhhs..h.....hhhhsphllshlsuhhhulllsshlh	..MPFT.F.uHPAAVLP.hsK...+p...s.pt...lsloALlLGSMAPDFpYF...........lpF+P..........aGslGHsWhGhlahNLPLshLLAhla+hllKcPhlsaLP+sas.shasa.shs...p..tas..htoh..+pa..h.......VF..shSALhGhlTHVlWDuFTH..psGa.FVhplshLpppl.......h.sIPlYKhhQHGSTslGlllLlahla....+atpc..psp.chhhth.......pcKhpaWhslh...lluhll.hhlashl.s.a.h.....hatlGthIVshlsu.hsuhhlsslla.........................................................	0	7	16	21
+13646	PF13804	HERV-K_env_2		Retro-transcribing viruses envelope glycoprotein	Coggill P	pcc	Jackhmmer:P61569	Domain	This family comes from human endogenous retrovirus K envelope glycoproteins.	19.40	19.40	23.30	22.20	18.20	17.10	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.16	0.71	-4.74	16	352	2011-02-14 16:01:45	2011-02-14 16:01:45	1	5	6	0	22	230	0	167.60	89	44.44	CHANGED	TPVTWMDNPIEVYVNDSVWVPGPTDDRCPAKPEEEGMMINISIGYRYPPICLGRAPGCLMPAVQNWLVEVPTVSPISRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCP	..........................................TPVTWMDNPIEVYVNDSVWVPGPTD.DRCPAKPEEEGMMINIS..IGYRYPPICLGR......APG......CLMPAVQNWLVEVPTVSPISRFTYHMVSGMSLR..PRVNYLQDFS.YQRSLKFRPKGKP.CPKEIPKESKNTEVLVWEECVAN..S..AVILQNNEF.GTIIDWAPRGQFYHNCSGQTQSCP.............................................................................	0	17	17	17
+13647	PF13805	Pil1		Eisosome component PIL1	Coggill P	pcc	Jackhmmer:O74960	Family	In the budding yeast, S. cerevisiae, Pil1 and another cytoplasmic protein, Lsp1, together form large immobile assemblies at the plasma membrane that mark sites for endocytosis, called eisosomes.  Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalise nutrients in all eukaryotic cells.	27.00	27.00	27.10	27.70	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.76	0.70	-5.25	7	285	2012-10-03 12:17:00	2011-02-14 17:38:51	1	8	137	3	215	271	1	249.20	51	65.78	CHANGED	MHRTYSLRsSRsPTASQ..LpsPPPPsSoTKotpaFGpsulu.aohR+ssAGuhGP-LuRKLuQLVKhEKNVhRShElsuRER+-sA+QLShWGE-.................sDDDVSDVTDKLGVLIYElGELEDQaID+YDQYRlTLKSIRNIEuSVQPSRDRKpKITDpIA+LKYK-PpSP+IsVLEQELVRAEAESLVAEAQLSNITREKlKAAasYQFDAh+E+uEKhALIAGYGKtLLELLDDoPVTPGEoRPAYDGY-AS+QIIhDAEsALspWsLDsAuVps	............................................................h.stst......................ttsss.s...S.osp.s........hh..sp..t..uhu....pshR........ht.s.t..G...shs.P..-Lu....+KLspLlKhEKslhcu....hEhsu+ERhpsApQLShWG.ps..........................s.D.-.D.VSDlTDKLGVLlaElGELEDpas-+.aDpYRlolKSIRslEuSVQP.SRDRKp..KI....o....DcI....A....p.L.......K.....Y...K..........-.....P.......p....S....s....K.......l.......sV.......LEQE....L..VRAEAEoL.....VAE.......AQLSNITRp.......KlKsAasapFDAlhE+uEKhAlIAsaGKtLL-L..l..DDoP....VsP......GEoRsAYDG..a-s.o+pIl.DAEsuLpsWp.s.s.h.......................................................	0	56	115	183
+13648	PF13806	Rieske_2		Rieske-like [2Fe-2S] domain	Coggill P	pcc	Jackhmmer:Q8FCX0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.21	0.72	-4.31	77	1917	2012-10-02 12:49:59	2011-02-14 17:40:20	1	23	1666	11	493	2846	625	103.40	36	52.55	CHANGED	sWpslCslcDlhPsoG..VsALl.s..spQVAlF+s......t.s.s.....plaAlsNhDPhupAsVLSRGllGs.h.tGchsVASPLaKQ+FsLpoGpClE...................sss..hsltsaslRlp.sGpV.Vp	....................................................................WhslC.pl--.lh....P.t....sG.....hs.s..l..l.......s......s.......c..p.....l...AlF+s......pss...........pla.AlsNhsPa...c..u.....ul...L.....S.....c......G.l...........l............u................s.....c........t..............t..............p........................h.......V.....ssPL+KQ+Fc...L.....p.....s......G..t..s.h.-........................................s.-.p...hsVpsYss+.Vc..DGtV.l.h...........................................	0	114	271	403
+13649	PF13807	GNVR		G-rich domain on putative tyrosine kinase	Coggill P	pcc	Jackhmmer:Q8FKJ4	Family	This domain is found between two families, Wzz, Pfam:PF02706 and CbiA Pfam:PF01656. There is a highly conserved GNVR sequence motif which characterises this domain. The function is not known.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.62	0.72	-4.23	72	3261	2011-02-15 09:40:19	2011-02-15 09:40:19	1	7	1874	0	746	2626	476	78.50	26	13.58	CHANGED	pTQQclL...RLpRDVcVspplYspLh.sptQp.hpls.p..AuslGNVRIlDs.A.sstsc..PVKPKKsLlllluhllGhhluluhlllRph	..............................................h....plpRphpstp.plYhtLL.p....+..pp....hpls...p....st.ss....u...s...l.....+..l..l..Ds...A..hs..s....t...Plp...P..++.tL.ll.l.l.u.hlLGlhlu.lshsll+..h.........	0	230	467	612
+13650	PF13808	DDE_Tnp_1_assoc		DDE_Tnp_1-associated	Coggill P	pcc	Jackhmmer:Q2EEQ8	Domain	This domain is frequently found N-terminal to the transposase, IS family DDE_Tnp_1, Pfam:PF01609 and its relatives.	30.30	30.30	30.30	30.60	30.20	30.00	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.74	0.72	-4.32	95	1944	2011-02-15 10:37:59	2011-02-15 10:37:59	1	5	565	0	251	1556	231	80.30	40	30.01	CHANGED	LhpthsplsDsRp.sp.shcasLsslLhlslsAll.uGucuap-Itpaups+...phLpphh..sh..pG.......lPSccThpRVhptlDspthppsatpWhp	...................hphhp.l.D.Rp.th..phcHpLscILhLslsAVI.uGA-uWc-IE-FGcs+h..-aL+pah..sh..cpG.......lPscDTlsRVlu.pl..sstthppthhpah..................................	0	73	179	221
+13651	PF13809	Tubulin_2		Tubulin like	Eberhardt R	re3	Jackhmmer:D3EKE8	Family	Many of the residues conserved in Tubulin, Pfam:PF00091, are also highly conserved in this family.	25.50	25.50	25.80	26.10	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.39	0.70	-12.16	0.70	-5.50	23	225	2012-10-03 12:11:42	2011-02-15 14:23:36	1	7	203	0	66	232	45	326.50	31	31.02	CHANGED	llIGLGGTGt-llt+lR+hIhppatt..................sthshlsFLhlDT-ps...........hstp.....thshcphcchhthhsspsssshhpphp.........sastlpp.......WhPsch.p...........shpslcsGAGplRslGRLAF......hspappIpptlpsthc...............h........hthcstssulslalVuSLuGGTGSGhhlDluYplRphh......ttpsshtlsuhllhPs...hasshsss......sphpANuYAALtELsaasshsscapsphstttspph.spps....................PFDhsYLluspNspsth..hshcplhphlApsIa.LphosthustppshccNhhpphtpssststs..................ahsFGhusIthPh-pItshlth+lspphlpha	...............................................................................................................................llIGLGGhGuplhtpl.hcp...l.c...........................-p.cp.lt..hhshDTshs..............................................slsphcc.hh..p..hh..sp.sssuph..pchh....................spP..pIsc..........Wh.Ph-.ph............spslspG..A..G..QlRsluRLuL..................s+l...ss..hhpplcchhs..................................ssucts.phul..p...VhlVoSLAGGTGSGMFLplAhhLRphl......htpcshh..ltuhhlhP-...lhspspsss.......hcplpANG...YAuL+E.Lcthphs...sstt..hs...tp.tthsh..php...hpss.....................................Pas..hsaLhsh....cNh.c..G...ptl...tshsphhc.h....ApsIh.hthhsshus.tph..stp......c..s...hpphtpsss.p..sp...................asshGhuplhhPh-clhphsAh+huhphlp..........................................................................................................	0	19	47	55
+13652	PF13810	DUF4185		Domain of unknown function (DUF4185)	Eberhardt R	re3	Jackhmmer:D0L2Z5	Family	\N	25.00	25.00	25.00	25.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	316	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.31	0.70	-5.53	52	408	2011-02-15 14:28:20	2011-02-15 14:28:20	1	10	213	0	128	358	13	297.80	29	69.59	CHANGED	TGs..........spTsp+aslsGTDLGIhacsssG....phhhsFGDTFu.........ssssGs.....sWRSNllhhSs.spslsc..Gl.........thsusst..ss.sp.Acpll.s.s.p.......sh-h......ThIPTuuIsls....s..spYlphMol.+sWus.s.....W.TNaoslshSsDsGpoWspsststpsss...........sG.sp.....h..suhsp.......scG..aVYhauT.ssuR..susshLuRV...tsplhsh......s.....uYEaWssss.......W..upss...usPllsus..sGElSlpap...t.hG+WlhhYhs.........s..s.tslshRsAssPpGsWo.stslssshp..................hs.p..LYGuYIaPhS.p..s..ttLaaslSpWs.........sYNVhhh+s	.................................................................................ps.tcaulsuTDLG.h.h-.sss...........pllhhFGDoFu..........sts.Gt.....tWpssshhpsp..spslss..Gl....................phsusss.........thuppll.s.s.............s....th......ohlPousl.sls..........t.......ppYlphhoh.+s.hss......................hotlshSpD.s.GpsWpshstshpsss.......................st.st....t....h.sshhp....................ssG...alYhhu....o....s........s........R.......s........s.........sshLsRs..s..p.plh..Dh.................s.....papaWsuss.t...................W.....s...pss.....hoPl..h..s......ss.................lG.Eh.Slph.............spalhhYhs.........s...st.....ss...lhhRs...A..s...pPpu..sWu.stslssshp................................hs.t...hYusalpPhS.....h....s...........p.LhhhlS.Ws............sYpVh.hp....................................................................................................................	0	40	89	115
+13653	PF13811	DUF4186		Domain of unknown function (DUF4186)	Eberhardt R	re3	Jackhmmer:D0L5G5	Family	\N	25.00	25.00	40.50	40.40	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.54	0.71	-4.37	43	607	2011-02-15 14:30:59	2011-02-15 14:30:59	1	3	591	0	60	245	5	107.10	72	88.23	CHANGED	ph-plFpRLu+SsFRuRF...+Lstc-psYlpcKGhssIppHApDFlscRLAPAhPsNDGKQTPMR....GHPVFlAQHATATCCRGCLpKWHtIstG+sLotpEQpYlVsVlhpWlpp	.....sh.-sLFARLuRSpFRSRF...RLGhKERQYCh-KGAsVI-pHAADFlA+RLAPAhPANDGKQTPMR....G..HPVFIAQHATATCCRGCLAKWHsIPQGhsLSEpQQcYIVuVIa+WL..Vl............	0	14	31	43
+13654	PF13812	PPR_3		Pentatricopeptide repeat domain	Coggill P	pcc	Jackhmmer:Q9USP3	Repeat	This family matches additional variants of the PPR repeat that were not captured by the model for Pfam:PF01535. The exact function is not known.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.43	0.74	-7.99	0.74	-3.22	132	5769	2012-10-11 20:01:04	2011-02-15 14:46:39	1	1960	345	0	4254	55882	730	33.00	18	6.79	CHANGED	htsassllpshs..c.tup...hpt....s...hplhpp.Mp.p.p...u......lpP	......................tasslls.s.hu......+..sGp............hcp....................A..........hplhpp..Mt.t.t....t........................................	0	932	2789	3676
+13655	PF13813	MBOAT_2		Membrane bound O-acyl transferase family	Coggill P	pcc	Jackhmmer:O74380	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-10.18	0.72	-3.91	101	505	2012-10-01 20:09:06	2011-02-16 11:45:15	1	13	129	0	397	1144	83	88.40	25	20.91	CHANGED	aP.s.lFGs...h....hpA.....h...o.....lpp.....FWGc.hW..HQhhRt....hhps....h....u....phl....h+t.lht........p..........ht+hhplh...hsFhlSGllHhhsshhhst............pt.....shh....FFhh	...............................PhF.sp.....htu.....p...S.....LpcFWG+..t............W..Hphhpp..................hhps........s....u....hh.......spt.hht...............pt.......................htphstlhssFhlSGl.hHths...hhhsht...........sh.........hh.FFh.h..........................................	0	152	254	343
+13656	PF13814	Replic_Relax		Replication-relaxation	Eberhardt R	re3	Jackhmmer:D0L6G0	Family	This family includes proteins which are essential for plasmid replication [1] and plasmid DNA relaxation [2].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.29	0.71	-4.45	47	432	2012-10-04 14:01:12	2011-02-16 13:12:31	1	3	244	0	81	370	8	165.50	19	62.86	CHANGED	Lthl..tcHphLoscQltplhhsstt.........tspppLpcL.pphphl.cphp.................ts.uptshhYhLsttG......tchl............st.ts.........t......tt............pttt...hsss......t.pls.HplslschastLh.tts.+pt...s..hp..ltcWh.....sE.psttt..h.............t..p..h.lpPDuhhthptss.......tthtaalEhDpuTEshtp......ltpKlppYtc.hhptt............tt..........s.hPl....l	.................................................................l..hthhshpplhthh...t.h...........sspphLpc.L...p..t......hl.pphhh..........................ttt...hhahL.sppG...hphh..................tt........................................t..hhss...t.plt...HpLhhs-hh..lphh..p.s.....t......................tap..............hEtphthp..h...........................tttt...t..h.lhPDshhhhppp....................hh....lElDpspps.hph.........htcKl.ppYtc.hhp...........................................................................................	0	34	66	73
+13657	PF13815	Dzip-like_N		Iguana/Dzip1-like DAZ-interacting protein N-terminal	Wood V, Coggill P	pcc	Wood V	Family	The DAZ gene-product - Deleted in Azoospermia - and a closely related sequence are required early in germ-cell development in order to maintain germ-cell populations. This family is the N-terminal region that is the only part of the protein in some fungi and lower metazoa.	26.20	26.20	26.40	26.40	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.20	0.71	-4.29	16	230	2011-02-16 13:19:29	2011-02-16 13:19:29	1	6	105	0	130	203	1	116.60	34	17.34	CHANGED	FpFpsRp-plDWR+luulDl-+l...s+-hDlsTLQcsl.sIoFsclpsEcssp.....s-shhLKLa+LuQLsIEYLlasQ-hLssp...spL--+lpps.pttcptcpphs+ppc-hphl.KcEs+	........FpFp..R..p.cslDWR+luulDl.D+l...spchDltsLQ-plt...s.lTF.CsL-sEcssp..........lDPsl.lKL.hRLAQLsIEYLLH..sQ-......hLssp.........lppLcccLptu.tptpphcppltcpsp-l+tl.+cE.+...........................................	0	52	68	93
+13658	PF13816	Dehydratase_hem		Haem-containing dehydratase	Eberhardt R	re3	Jackhmmer:Q76K71	Family	This family includes aldoxime dehydratase, EC:4.99.1.5. This is a haem-containing enzyme, which catalyses the dehydration of aldoximes to their corresponding nitrile [1]. It also includes phenylacetaldoxime dehydratase, EC:4.99.1.7. This haem-containing enzyme catalyses the dehydration of Z-phenylacetaldoxime to phenylacetonitrile [2]. The enzyme forms an elliptic beta barrel, composed of eight beta-strands, flanked by alpha-helices [3].	25.00	25.00	25.90	25.40	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.94	0.70	-5.38	33	119	2012-10-02 00:20:33	2011-02-16 13:30:49	1	4	97	20	74	142	8	286.30	33	82.63	CHANGED	hAhhGlQhpus.st.........stAhssltphlpt..hssssuPpth.-hsthsDssGhpshlhluYWp-sssacpWhpssshssaWsuhs...tpshGhapElhsssscRaETlaSsp-hh.Gluplhs.shos.hpcHuYWGuhRDRhPhopsDthts.........sspsth.sssstttGRlhls..sh.-NlshIRSGQDWussss-E+chYh-pl-PsLppGMcaLp-putcsGChosRahpshDs....c.ss............h.hccohsluaacsLssLE+Wu+oH.THlsIassFhchs.pshs....thcLRLaHEVuVLcsspthFEYlsCHssTGh	....................................................huhhGlQhpssst..................ssAhpsltphhtt....hstssuPsta.-hsph.sDspGhtshlhluYWps....ssappWhpssshssaWpu.s...t.pps.....hGaapElhssps-RaETlaut.ch.h.Glutlhs.shos.hpcpuYWGuhRDRh.Phops.D.hhts.....................ssp.th..s.sssttsuRlhlt..sh.cNlshIRSGQDWussps.cERphYh-plcPsLppGMsaLcDpGtpsGChusRahpslD...........c.tp...............h.hccohsluaapsLspLE+Wucs.Hs.THlpIFssFhchs.pths.....hpLRLaHEVsVhcstpthaEYlsC+stTGh................	0	10	29	59
+13659	PF13817	DDE_Tnp_IS66_C		IS66 C-terminal element	Coggill P	pcc	Jackhmmer:P39351	Family	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-7.80	0.72	-3.94	114	3268	2011-02-16 13:47:29	2011-02-16 13:47:29	1	17	854	0	386	2560	227	38.70	51	11.84	CHANGED	SLIpTAKLNGl-PpAaLp-VLsR.I.ss..a.st.sRlc-LLPWs	.......SLIuTC+LNsl-P.EuYLRa...VLsh.l..s-.....W...Ps....N......R....Vs-LLPWp............	0	81	201	298
+13662	PF13820	Nucleic_acid_bd		Putative nucleic acid-binding region	Coggill P	pcc	Jackhmmer:Q14686	Family	This is a family of putative nucleic acid-binding proteins. Several members are annotated as being nuclear receptor coactivator 6 proteins but this could not be confirmed.	21.60	21.60	23.20	21.60	20.60	21.00	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.64	0.71	-4.61	6	169	2011-02-17 13:43:59	2011-02-17 13:43:59	1	25	69	0	126	158	0	143.50	40	12.42	CHANGED	hSNlaVsspGplc..hhptpLDpL+ppLspLhuscpSplhh+chcha+SlhVcFoIPREssssLRphA-puD.cLhhhGIpS....lQI-u-ssI.slsppushaD..st+p..ssslc.lGsSsRscttps......tShstL.u.sl.ucshsspstsh...ussph	................SslaVsh+Gslc...hp.pLDplhps.lssL.h.p.h...c...........p.Sp............l.Khpthc.apSlhVpFsIPREssthLRhhAppss.pLh.hGlhS......lQI..-uEs...sI.plt.utsh.pshR.........sssht.sGsSs.Rhctths...........tuhstL.th.s..ussh..thtssuS..h.................................................	0	82	87	106
+13663	PF13821	DUF4187		Domain of unknown function (DUF4187)	Coggill P	pcc	Jackhmmer:C6Y4A5	Domain	This family is found at the very C-terminus of proteins that carry a G-patch domain, Pfam:PF01585.  The domain is short and cysteine-rich.	27.00	27.00	27.10	29.60	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.22	0.72	-4.37	53	314	2011-02-17 15:57:08	2011-02-17 15:57:08	1	13	227	0	230	315	0	67.60	35	14.86	CHANGED	--E...............hc-.ptLsspEcLppLlpYLRpcapYCaaCuhpYcspc-l...psCPGss.................................E-DH	...........................pE...sc.-tLssp-+LphllpYLRcpapYCaaCshcY-stc-L...cpCPGss....ptpH.....................................................................	0	65	115	181
+13664	PF13822	ACC_epsilon		Acyl-CoA carboxylase epsilon subunit	Eberhardt R	re3	Jackhmmer:D0L8S8	Family	This family includes the epsilon subunits of propionyl-CoA carboxylase, EC:6.4.1.3, and acetyl-CoA carboxylase, EC:6.4.1.2. These enzymes are involved in the biosynthesis of long-chain fatty acids. The epsilon subunit is necessary for an efficient interaction between the alpha and beta subunits of these enzymes [1].	25.00	25.00	25.20	25.70	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.16	0.72	-3.62	83	404	2011-02-17 16:15:50	2011-02-17 16:15:50	1	1	355	0	109	286	9	60.60	33	71.49	CHANGED	pshl+Vl+GsPosEElAALsAVLsuh..uusssssssss..........stWuc.sc......htt..hsuPsuW	.......shlpVl+GsPTsEELAALlAVluuh.........uusussstssst...............stWsp.hc......htcshh.u.tua..........................	0	30	81	105
+13665	PF13823	ADH_N_assoc		Alcohol dehydrogenase GroES-associated	Eberhardt R	re3	Jackhmmer:D3EFL6	Domain	This short domain is frequently found at the N-terminus of the alcohol dehydrogenase GroES-like domain, Pfam: PF08240.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	23	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.24	0.72	-6.44	0.72	-4.28	120	1545	2011-02-17 16:20:05	2011-02-17 16:20:05	1	5	1130	2	440	1190	19	22.70	51	5.97	CHANGED	MKAlsapGt+cVcV-pVPDPcIp	.MKAlsa+GsccVcV-s.VPDPtIp...	0	117	274	373
+13666	PF13824	zf-Mss51		Zinc-finger of mitochondrial splicing suppressor 51	Coggill P	pcc	Jackhmmer:Q9UTB4	Domain	Mss51 regulates the expression of cytochrome oxidase, so this domain is probably DNA-binding.	27.00	27.00	28.00	28.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.04	0.72	-4.11	25	148	2012-10-03 05:12:49	2011-02-17 17:23:16	1	5	144	0	111	149	0	63.70	44	12.10	CHANGED	hCPhss......+............................clpapCPcCGlPsaCScEHWccD.EtHtc..hCpsLRp.lNE.s-HDL	.................hCPhss...+p..................................tclpapCPcCGlPsaCScEHWtcDhEtHhp.lC-tLRp.lNc.D-HDL......	0	26	56	93
+13667	PF13825	Paramyxo_PNT		Paramyxovirus structural protein V/P N-terminus	Coggill P	pcc	Karlin D	Family	This family consists of several Paramyxoviridae structural protein P and V sequences [1]. From a structural point of view, P is the best-characterised protein of the replicative complex. P is organised into two moieties that are functionally and structurally distinct: a C-terminal moiety (PCT) and an N-terminal moiety (PNT). PCT is the most conserved in sequence and contains all regions required for virus transcription, whereas PNT, which is poorly conserved, provides several additional functions required for replication [2]. P protein plays a crucial role in the enzyme by positioning L onto the N/RNA template through an interaction with the C-terminal domain of N. Without P, L is not functional. The N, P, and L proteins of SeV and measles and mumps viruses are functionally equivalent. However, sequence identity between proteins from these viruses is limited, and the viruses have been placed in different genera (Respirovirus, Morbilivirus, and Rubulavirus, respectively).  SeV P protein (568 aa) is a modular protein with distinct functional domains. The N-terminal part of P (PNT) is a chaperone for N and prevents it from binding to non-viral RNA in the infected cell [3].	21.70	21.70	22.20	21.70	21.10	20.70	hmmbuild  -o /dev/null HMM SEED	309	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-11.67	0.70	-5.21	8	536	2011-02-17 17:37:57	2011-02-17 17:37:57	1	6	59	0	1	461	0	228.70	56	64.32	CHANGED	EQAYHVsKGLECIKALRtsPPDh.pIcEs.uhhscsssssspsssTscpEEtDoQslscSCpPAhGSspsutshtcspGsGE..sNssssEhttsPc-.tpsusulpCYaVYDHSGEcVKGIEDADSLlV.uGssusssFpGG-suS--SDsDSGEsDoEGsAsoshGSust.pssRAoDVEplpu-ElptLLRoQppsssth+sGKTLpVPssP-sppussSspPIKKGT-cRSsSaGTthsuu.TuGATQsAhKSsuuSStPuASAGNVhpssoNAchhQcsp.ESGTphSP+opNptES-sEYDDELF	.....................................................................EQAhHVppGLECl+AL+tpP.s..tlpEs.uhhsphpssstpptsssh.ppctsspslscsp.sAhGSs..sutsh.ps.GstE..usss..pht.ssts..tsusGlppYaVYD.HSGEtVKGIpDAD...SlhV.uGhsusps..hpsG-sp...-sSs.D.GEs.oEG.A.oshG.u.h.hs.RAuDVphh.ttElptLLRhpppss.h.+.GKTLphP..sP-st..pussppssIKK.G..TctR...ASaGht.Isuh.h............................................................................................	1	1	1	1
+13668	PF13826	DUF4188		Domain of unknown function (DUF4188)	Eberhardt R	re3	Jackhmmer:D0L3R6	Family	\N	25.00	25.00	25.00	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.77	0.71	-4.00	48	173	2012-10-02 00:20:33	2011-02-18 08:00:56	1	3	167	0	98	217	26	116.20	33	56.30	CHANGED	lVVFllGMRlN+hhul.....ppWhslhtAMstMlcE.Ltps.....-.hGhLut.cs.ah.h......csshllQY.WRuhEsLcsaA+..sp.HhtAWcpFsppst.s...s.ssVGIaHETYhl.tGpaEsIYsNM.P.shGL	............................................lVVFhlGhRhN+.huh......tah.lhtuhstMlc-.Ltpst.........chGhLuhp.hh.s............psh.hhlpY.WRuh-sLppaA+..st.Hh..pAWch...aspthps......sspVGIaHETYhl.tGpaEsI.YsNh.P.shGL...............	0	21	61	84
+13669	PF13827	DUF4189		Domain of unknown function (DUF4189)	Eberhardt R	re3	Jackhmmer:D0L9M9	Family	This domain of unknown function contains six well-conserved cysteine residues.	25.00	25.00	25.20	25.50	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.15	0.72	-10.90	0.72	-3.75	66	395	2011-02-18 08:10:12	2011-02-18 08:10:12	1	7	227	0	89	316	4	96.50	27	61.71	CHANGED	paGAlAh..ssssGs....hGhuhshs.ocppAcptAlppCpt..........t.tsCclhshapNt.CuA..lAhstpstt........thususshp....pApppAlppCtptss...........pCplhh.tsCo	................aGAlAh..sss.us.....hGt.uhs..ts..optpApttAl..p..pCtt.............psC+llsphps........CsA..lA..hststh.................tsususshp....sAcpsAlspstt..............tstl.s.hsCs..........................	0	14	46	68
+13670	PF13828	DUF4190		Domain of unknown function (DUF4190)	Eberhardt R	re3	Jackhmmer:D0LA47	Domain	This integral membrane domain is functionally uncharacterised. One of the membrane helices contains two GXXG motifs that are usually associated with dimerisation.	35.00	35.00	35.10	35.00	34.90	34.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.00	0.72	-4.42	107	528	2011-02-18 08:18:59	2011-02-18 08:18:59	1	16	318	0	182	498	26	63.40	31	30.28	CHANGED	hAIuSLVh.ulhuhhh..........lsullullhGalAhspI+css..ppGcGhAlAGlllGhlslsl...hllh	.........hAluuLVh.ulluhhh..........h..lhullullhGhlAhspI++ss.....ppGcGhAlAGlllGhlslllhll.h..............	0	59	137	166
+13671	PF13829	DUF4191		Domain of unknown function (DUF4191)	Eberhardt R	re3	Jackhmmer:D0LAZ2	Family	\N	25.00	25.00	133.10	129.00	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.32	0.70	-5.23	55	434	2011-02-18 08:42:45	2011-02-18 08:42:45	1	1	433	0	112	285	112	229.20	39	91.39	CHANGED	s++s.cpp.....pphpQlhpuaphpR+pDspl.l.hhluuhluslslhlllGllhs..th...hhhlllGlh....lGlLsAhhlFuRRsp+usYsplEGQPGAAussL.p.slRt....sWplss.sVAss.....+p..D.....hVHRllG+PGllLVuEGsssRl+sLlspE+K+lsRlls..ssPl..aslhlGsu..EGQVPLpKLp+plhKL..P+s...lsps-lsslspRLpALs.....ssthsl...PKGPhPppA+.t+sshR	........s..csppttphpQlhpsFphpR+pD.pLl.hhlGu.Flssl.sl.hhllG.llhs.....th....ahhlllGlh....lGsLsAhhlFsRRAp+usYs+hEGQsGAAuhALs.slcp.......tWpsos.uVAhT......+p.D........sVHRslGhsGllLlGEGs.ssRl+sLLupE+KRhtRlss..slPl..acIllGs.G.......-G....QVPLcKLc+pltKLP+.s....................lossplsslssRLcALs....htsssslPKGPhPp..s.h.Kh.spsh...........	0	34	82	104
+13672	PF13830	DUF4192		Domain of unknown function (DUF4192)	Eberhardt R	re3	Jackhmmer:D0LBR8	Family	\N	25.40	25.40	26.00	26.10	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.13	0.70	-4.78	56	428	2011-02-18 08:58:27	2011-02-18 08:58:27	1	2	346	0	131	346	78	282.00	26	82.83	CHANGED	Pu-llAAlPtlLGFhPpc.SlVllsl..................sph.GsshRhDLs.......hst.sptlst.hh...........s...t.....tpscsslsllhss..t.t.s............thpthhptLtpthsst.slsl..hsshhh.plssGphWphh...............s......ssGt..shssssossssA.slhs.Gphs.hssRs-ltAtlt.....s.s.h.tstthstshpttsht.t.ph.......t............th..t..h..chhttsspphspu.............phhsss.....tphutluhsLs-spl.RDthhshsst...csussA.tpLWttluRphsus...h...RusslsLhuhsAaspG-ushAshALstAl.....ps-Ps.ashApLLppALppGlpPc	.......................................t-llsslPhlLGFhPpc.SlVhlsh.......................ts...ssth..Gh..VhRhD.Ls........t.ssthsthAt...h.................h.........sssstslslhhsp.....p.tts............................ht.hhts..Lt....psltth..shs..l..hsuh...tl.ssGthWpsh.......................tsss........pts......hc.sssshhsA.ulh...p.G.ht.l...hssRssl.s.hls..................st...t.....tp.sss.htthsttt..th.t......................................tsh..phhhtshshh..tsu..................................pplss........tthsplu....s.ulpcspl.RDhlht.hh.t....................tpAs...t....s..pl......Wttlschh.ss..h.................tstsLsLhuhsuahpG-GshAulslptuh.....thtss.a.....phsthLpphlpsGl.Pt...............................................................................................................	0	42	92	123
+13673	PF13831	PHD_2		PHD-finger	Coggill P	pcc	Jackhmmer:P55198	Family	PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2].  Several PHD fingers have been identified as binding modules of methylated histone H3 [3].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.41	0.72	-4.63	28	1358	2012-10-03 17:27:21	2011-02-21 11:26:41	1	92	289	2	819	1377	16	35.50	47	3.52	CHANGED	ss.llsCs..pCslpVHtsCYGlsp.sst.....WhCs+Ct	...t.N.llaCD...tCslsVHQ..pC....Y.G...lsh...l...P.p...G..p.........WlC+pC.....	0	223	368	595
+13674	PF13832	zf-HC5HC2H_2		PHD-zinc-finger like domain	Coggill P	pcc	Jackhmmer:P55198	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.48	0.72	-11.31	0.72	-4.06	34	1557	2012-10-03 17:27:21	2011-02-21 11:45:05	1	99	292	0	942	2258	15	113.10	38	10.90	CHANGED	scCsLCshcGGAl.KpTs..-.sp..WsHVhCAlh.lPElpFs...sst...phpPl-.lppls.p..R..hchpChhCcpp.........tGACIQCspsp...CtssFHsoCAptAGlhMchc........sh...................h.hhshCt+H	........................................................s.pChLC.......P.......p.......c.......s.........G.......A.......h.........K.......p........T....s...........s.....s.....+............W......s..HVsCAla.....lP....E.V...p.Fu..............ss.t.......................p.hE......P...ls......l.............p.p.IP......s..........R.........a.p..L.......pC.hlC+pp........................sGA.Cl.Q.........Csptp.........C..h.........suFHVTC.A.p.p.u...G.lh..hch.p.....s.t...................th.hhsaC.hH.......................................................................	0	261	429	688
+13675	PF13833	EF-hand_8	EF_hand_6;	EF-hand domain pair	Coggill P	pcc	Jackhmmer:B4DPI1	Domain	\N	27.00	13.80	27.00	13.80	26.90	13.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.45	0.72	-4.35	49	8724	2012-10-02 16:17:27	2011-02-21 13:12:04	1	472	1753	448	3941	29164	1599	50.10	27	16.73	CHANGED	ppGhIoh-sLpcsh.thh..shp.....hscp-.lpshhpthDhDsDGtlshpEFhshhhch	........................................................pG.Istp-Ltphh....pth.........G.p..................................ho..p...p...-...l.....p....p....h....l....p....p........h....D..t.....D....s......s...G..p...l....s..a..p..EFhthh...t..........................	0	1329	2024	2921
+13676	PF13834	DUF4193		Domain of unknown function (DUF4193)	Eberhardt R	re3	Jackhmmer:D0LBT3	Family	This domain of unknown function contains four conserved cysteines and a conserved histidine, including a CXXXXH motif.	25.00	25.00	25.70	27.20	23.30	17.00	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.46	0.72	-3.83	55	502	2011-02-21 13:14:06	2011-02-21 13:14:06	1	1	430	0	156	293	158	97.70	59	97.30	CHANGED	MATDYDAPR+s-.D-lspDSLEEL.KucRs-p.touslD.DEs-sAEuFELPGADLSsEELoVcVlP+QsDEFTCuSCFLV+HRSQLAc.Ecs...GphlCpDCA	...........MATDYDAPR+o-...D-lsE.DSLEEL.Kup..Rs-p.tSusVDsDEsEsAE.sFELPGADLS...sE.ELoVRVlP+QuDEFTCoSCFLV+HRSpLAp...Ecs...GphlCpDCA....	0	49	105	144
+13677	PF13835	DUF4194		Domain of unknown function (DUF4194)	Eberhardt R	re3	Jackhmmer:D0LDY0	Family	\N	25.00	25.00	25.00	25.00	24.60	23.60	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.73	0.71	-4.81	69	425	2011-02-21 13:18:36	2011-02-21 13:18:36	1	1	392	0	144	392	34	162.10	19	70.16	CHANGED	llpLLcsshlpsppp....plWptllcp...pstlcshLsslhLcLllDcstGhAahcph..p.tp.ts.........pLlpR.p..sLoh.pollLlhLRpphtctp...t.ts.spchllsp--lh-tlps...ahs.tssscsphtcclcsslp+lt.chuhlcphcs......-sp.......aclpsllcshlss-hls	.....................................tLhpt.hlptpp.......phaphlhcp...pstlcshlsslslcLll....Dcp..tshhalpst...........t.t..................hhpp..p..pLshhpollLlhLRphhp-t.....sh.s..stp..shl..sh-Elhphlps...ahs...pscsthtpcl.cp.sl.pchp.phshlpthcs.........t.csp......htlpPhlthhhssp.l.t.................................	0	48	96	127
+13678	PF13836	DUF4195		Domain of unknown function (DUF4195)	Coggill P	pcc	Jackhmmer:Q8ND82	Domain	This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.	27.00	27.00	29.50	31.50	24.50	19.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.20	0.71	-4.58	4	132	2011-02-21 13:42:38	2011-02-21 13:42:38	1	4	32	0	55	149	0	164.30	43	25.84	CHANGED	IFVGEISSSKPAISNILNRssPSSpS+GlKNGshs.GIoshFKPTSQ+hpNPsSNPVsA.P.sFHPtS+SS-SSVhVQshSKPsaspNSspVsSssSS.LLFD.TQDo.Lsp.QshPslshsGhspoSal.K+PSTScVNSVNPKKPKsSEslSthssSoslsS.pSPSVsSSQshLSpGsNoSSs	...............IFVG.hSsSK..PslS..NIL.NRssP.uS.S+thKpsthpp..shsthhpPsSpchhsPoSps..Vss.P.....s.psESRSocSsl.h.l...pshSK..P..sahpsSsQVss.ssSSpLh.sh.sp..p.o..ls..pss.s...s...lshsGhscosh.lSKR.sSTS-l.N..SlNPK+PKhS-ulsthsuSush.sS..spS.ohsopQsh.upsssoS..........................................	0	4	5	9
+13679	PF13837	Myb_DNA-bind_4		Myb/SANT-like DNA-binding domain	Coggill P	pcc	Jackhmmer:Q6P1R3	Domain	This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular Pfam:PF10545 seems most related.  This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.19	0.72	-3.85	185	1844	2012-10-04 14:01:12	2011-02-21 14:15:41	1	81	168	2	1133	1879	0	91.10	22	25.60	CHANGED	pspWscpEsptLl.plh...sp....hc....hpt............pt+st.lWcplupp....h.......t...p.....p.....G.....h...p....R.osp...QC+pKacsLp+pY+pt..+p......t.t....t..tp.s.....p....s....h...a...............................Fcpl-pl	........................................................t..pWs.t.p.EsttLl.phh.......pp....hcttht...................................sst+s.p..hac..tlupt....h.......................t...c.....p........................G..........h.....t.....R.osp...Q.C+pKa.cs.Lp+pY+..+h..+p............t.t........tts............p.....s....h...a................................apphct..............................................................	0	211	533	829
+13680	PF13838	Clathrin_H_link		Clathrin-H-link	Coggill P	pcc	Jackhmmer:Q8NHS4	Domain	This short domain is found on clathrins, and often appears on proteins directly downstream from the Clathrin-link domain Pfam:PF09268.	27.00	27.00	27.40	27.20	26.50	25.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.10	0.72	-4.08	51	782	2011-02-21 14:58:18	2011-02-21 14:58:18	1	37	456	9	307	484	4	59.40	63	6.54	CHANGED	sLsGA-sLahppFppLhspGpYpcAA+lAAsoPpGhLRTspTIp+Fp..phPstP.Gp.s.PlLQYFuhL	.......................sLsGAE-L..FsRKFNsLFAQGsYuEAAKVAAsAPKGl.LRTspTIp+Fp.....slPsp.s.GQsS.PLLQYFGhL..........................	0	99	161	238
+13681	PF13839	PC-Esterase		GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p	Anantharaman V	pcc	Manual	Family	The PC-Esterase family [1] is comprised of Cas1p, the Homo sapiens  C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing  resistance/coldacclimatization proteins typified by Arabidopsis  thaliana ESKIMO1 [2][3], animal FAM55D proteins, and animal FAM113   proteins. The PC-Esterase family has features that are both similar  and different from the canonical GDSL/SGNH superfamily [1]. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins [1][3]. The Cas1p protein has a Cas1_AcylT domain, in  addition, with the opposing acyltransferase activity [1]. The C7orf58  family has a ATP-Grasp domain fused to the PC-Esterase and is the  first identified secreted tubulin-tyrosine ligase like enzyme in   eukaryotes [1]. The plant family with PMR5, ESK1, TBL3 etc have a\	    N-terminal C rich potential sugar binding domain followed by the  PC-Esterase domain [1].	24.60	24.60	24.60	24.60	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-12.05	0.70	-4.58	109	1574	2012-10-02 11:02:24	2011-02-21 15:50:55	1	22	161	0	1001	1544	2	250.40	20	56.82	CHANGED	LPRFsupphLchhR.............sKplhFlGDSlsRspapSLlChLppshs.............................sppphhptps........t.hhaphpcassolpahhsPaLVp..p..............hlcl-plp.pts.ptht............ssDlllhNo.spWWhpp.thh..hs.h.............tpp.hpchshhtuactulpohtpalptslsstp............................................................opVhFpoh..oPsHhcsstWtt........u.tp.C.tp.............ts.thpsts.phhchltcshp.........th.psslphlsl.TthsphRp.......DuHsuhYtt.......................................pDChHWCLPGl.DoWN-lLhshlht	.................................................................................................................................sphsstphLph.hp..............sKplhFlGDSlsRs...apSl..lC..h..Lppsh........................................................ttt.......tt...........................t.hhhth...t..p.a..s...ho....l.p.a.h...hssaLsp........................................................................hhhcpht....ths..p.tht...............shD.ll.l.h.so.....stWahp..th.................................................................t.....phs.h.ht.u.aphslps..h....hphl...t.t..ph....tt...............................................................sp..l.hh..psh...sPsH....h.p.....st.......h.t..........st...C............................................t....th..t.....h.h..ph.h..p.hht.....................hth.hphl.sl...T....hhsthR........DuH.s..a................................................tDC.HWCls..G..h.DsasplLhthh..h.......................................................................................................................................................................................................................	0	251	600	806
+13682	PF13840	ACT_7		ACT domain 	Coggill P	pcc	Jackhmmer:Q8NAP1	Domain	The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements [1]. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.73	0.72	-4.45	192	6068	2012-10-02 00:29:19	2011-02-21 15:51:45	1	38	4053	48	1523	4779	2087	65.50	33	16.45	CHANGED	phppshttlplhGs.......hshthsGlhAplsssL.......uptsIslhhlS...oaposalLVppcchppAlpsLcp	.....................ppsluhlSlVGs......GM+s....hsG.luA+hFpAL..........ucs.sI......sI.h...hIo..oSEhsIShl.l..sp.cphppAl+sLp........................	0	466	918	1239
+13683	PF13841	Defensin_beta_2		Beta defensin	Coggill P	pcc	Jackhmmer:Q4QY38	Family	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	22.20	22.20	22.20	22.20	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.01	0.72	-3.59	114	633	2012-10-01 20:50:19	2011-02-21 16:25:20	1	2	61	0	227	564	0	30.50	36	38.63	CHANGED	cChpt..tGpCRp.pCppsEhhhth....C..tstphC.C	...pChpt..pGpCRp.pCppsEhhhth....C..tssphC.C......	0	33	34	39
+13684	PF13842	Tnp_zf-ribbon_2		DDE_Tnp_1-like zinc-ribbon	Coggill P	pcc	Jackhmmer:Q96DM1	Domain	This zinc-ribbon domain is frequently found at the C-terminal of proteins derived from transposable elements.	17.60	17.60	17.60	17.60	17.50	17.50	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.38	0.72	-3.54	30	124	2012-10-03 10:42:43	2011-02-21 17:07:58	1	6	55	0	68	155	29	35.10	32	6.86	CHANGED	ppCthCtp......pt.tp........opatCppC...s.....hsLChp........C	........................ppCphCtp......pthtp........opahCppC..s.......ssLChp...........C................	0	25	31	62
+13685	PF13843	DDE_Tnp_1_7		Transposase IS4	Coggill P	pcc	Jackhmmer:Q96DM1	Domain	\N	21.10	21.10	21.20	21.20	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	351	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.32	0.70	-12.02	0.70	-5.40	48	1008	2012-10-03 01:22:09	2011-02-21 17:19:41	1	50	126	0	857	1024	6	208.80	14	54.68	CHANGED	sPhphFphhhsc..cllppllppTNtthpph.................t.thpssshpElcsFlGlhllhGhh+..hsp....l..p-aWsss...hhu....hshhpssMohpRFptlhpsL+hs-...........s.t...s........tt...Dphtcl+.Llcthspph..pphYsPupplslDEsh.l....ha+.u+hshcphhs.sK.hphGh.chahhs-spouYhhph.....lhp....sp.ssth..t.................p.s......sspllhcLhp.sht.s.ps...+plhhDs..aasSls.LhppLhpp..shhusGslcps+t....thP.....psl..p.........pp...........h...pp...Gphhhths.......ss...l.hhhpapc..scplh.hloo...hps........psh...lptppps...t.........pp.....h...t..pPthlptYspphsu..V-...ptcphht...p.apsst...ps.ppWhppl.hhallshulhNAa	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	377	459	779
+13686	PF13844	Glyco_transf_41		Glycosyl transferase family 41	Eberhardt R	re3	Jackhmmer:O15294	Family	This family of glycosyltransferases includes O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase, an enzyme which catalyses the addition of O-GlcNAc to serine and threonine residues [1,2]. In addition to its function as an O-GlcNAc transferase, human OGT, Swiss:O15294, also appears to proteolytically cleave the epigenetic cell-cycle regulator HCF-1 [3].	25.00	25.00	25.20	25.00	24.60	24.80	hmmbuild  -o /dev/null HMM SEED	468	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.61	0.70	-6.52	5	1950	2012-10-03 16:42:30	2011-02-22 08:01:16	1	478	581	32	949	2116	1664	192.00	16	40.67	CHANGED	LRIGYVSSDFGNHPTSHLMQSIPGMHNR-+VEVFCYALSPDDGTNFRsKlMsESEHFVDLSQIsCNGKAADRIHsDGIHILlNMNGYTKGARNEIFALRPAPIQVMWLGYPGTSGAsFMDYIITDuVTSPlELA-pYSEKLAYMPHTFFIGDHAQMFsHLoERVlVctKssu.c.hDsc..tVlNus-.LcPlL-p.psKchV+-spscuGsclDhs+ocVsLPVl.hsT.sEPlcpMIsoGQIsssl.NGVsVQNGLuT.oQsNsKAATGEEVPpoIlVTTRuQYGLPDDAIVYCNFNQLYKIDPsTLsMWscILK+VPNSVLWLLRFPAsGEsNIppastchGlsssRIVFSNVAAKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWTGTPMVTMPtETLASRVAoSQLsuLGVPELIAKsRpEYpDIAlKLGTDtEYL+pIRAKVWpARsoSTLFNsKQYCp-LEcLahKMW	...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	267	562	790
+13687	PF13845	Septum_form		Septum formation	Eberhardt R	re3	Jackhmmer:D0LB95	Family	This domain is found in a protein which is predicted to play a role in septum formation during cell division [1].	25.00	25.00	25.20	25.40	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.95	0.71	-11.74	0.71	-4.80	89	373	2011-02-22 08:02:50	2011-02-22 08:02:50	1	6	246	0	129	352	62	180.70	24	53.38	CHANGED	psGsChsh.......................................................................................................................shsupstshs.......................................sVsCspsHssElh.ushslsss............P....utsshsstspctCs.pthpsYsu...st.h....ssslphhahhPoppSWpsG.sR.plsCh	..............................................................s............................................................................................................................................hpststt.s.ts...h.h.h.....sGsClshssss................hstsVsCspsHshEls.usls.....Lssphst..........P.upsp.sshhpstCs.ptsp.sY.lu..........s.th......ssslphhahs.ots.SWs.s.G.sRtVsC...................	0	33	98	123
+13688	PF13846	DUF4196		Domain of unknown function (DUF4196)	Wood V, Coggill P	pcc	Pfam-B_104093 (release 24.0)	Domain	This is a short region of ccdc82_homologues that is conserved from Schizo. pombe up to humans.  The function is not known.	25.00	25.00	25.70	25.70	19.90	18.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.68	0.71	-3.78	4	51	2011-02-22 13:26:22	2011-02-22 13:26:22	1	5	30	0	23	52	0	98.80	59	24.33	CHANGED	KcLhNosNSSshEEphscoKHp..DLsDpEKt.GQp-schNK+TGQIlE.ED.E.....-E.lp.s++p+lSS..lh.DSDppcpSD.h.+psu.....hK+.R+Vlps..SS.-.EppsPEc..pshhR+	..............................cpLhNousuSshEEEhNc.ccp..DL.Dp.EKHh.SQE-sDLNKpTGQIIE..-DlE.....EEpIKpGKRKRlSS..VMhDSD-SD..DSDILVRKVu.....lKRPRRVVEDE.sSSlEME..pcsP..EK..o.AAR............	0	3	3	7
+13689	PF13847	Methyltransf_31		Methyltransferase domain	Coggill P	pcc	manual	Domain	This family appears to be have methyltransferase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.08	0.71	-4.62	66	11527	2012-10-10 17:06:42	2011-02-22 13:32:39	1	237	4093	66	3510	72499	23508	157.30	17	50.53	CHANGED	hppshplLD.....lGCGsGhhshhlt......hs...puc....lhGlDhopctlphA+p....ptpphshp..slpFht...u-lpp.ls...ht........ppaDl........llsp..................ssl.......thhss.tpslp..............phhclL+ssGhlhhtshs.....................t.......tthppp.p.................................ttpchhph......hppuG	................................................................................h...stplLD..lG.C......G..s...G....h.h.s..h..t..lA.............................p.........ssp................................lh..G....l....D.......h.........o......t........p......h......l......p.....h...A....pp............................p..h....p......t................s.....h.p............s...........l....p...a..h..p........................us...h....p..p......l..s........ht....................ppa..D.l..........................................l...l.s..p...............................................................................................................tsh...........................th.h...t....s..........p....p....h...h..p....................................................p.h....h....p....h....L...p...s...s...G..h..l...h..h....t........................................................................................................................................................htthhhhhh.hh.h...h.h............................................................................................................................................................................................................................................................	0	1293	2284	3027
+13690	PF13848	Thioredoxin_6		Thioredoxin-like domain	Coggill P	pcc	Jackhmmer:Q96DN0	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-11.22	0.71	-4.48	54	1636	2012-10-03 14:45:55	2011-02-22 13:44:55	1	33	412	18	956	2074	42	177.40	17	37.01	CHANGED	Fps..tpptt..hctFpcsApphp.c..htFuhs....ppc....lhpp....hthpt..ssllla..+......t.......cp..pphphstp......h.shsslppalpppphsh.ltchs..c.s.htplhppsh..hlllh...hsp.t.sps.h....p.phppt....l..pplA.pph....p..s...p...lh..Fs.......hscsp...th.sc...hlp.hh.shst..s.chPhlshlc.ts.p...t...hhh....h....ps.p.hss....pplppFlps	...................................................................................tt..hp.ahpsApthp........c......h....Fs...hst........stp................lhpp.............hth....pt...s....s......ll.la......+..............................hcp....t..h.apsp................h..st.pp....l.p....p.a.l.....p.p........p....p..........h..........s......l......l..s......c.....h.s.....t....c.....s.....h.t...p..l....h..p.......s.....s....l................h....l....hhh.......hs.....p....s..sps.h...................p..pht.st..............h....ppsA..cpa...............................+..s..........p...........l......Fs........hhctc.......ph.tc....hh....p........h....sl..pt........t...p...h..Pslhl.hs..tp..p...t....hhh...........h......pp..p...hs.....pplppFhp....................................................................................	0	328	470	733
+13692	PF13850	ERGIC_N		Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)	Coggill P	pcc	Jackhmmer:B8ZZK7	Domain	This family is the N-terminal of ERGIC proteins [1], ER-Golgi intermediate compartment clusters, otherwise known as Ervs, and is associated with family COPIIcoated_ERV, Pfam:PF07970.	27.00	27.00	27.30	27.50	26.50	26.60	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.07	0.72	-4.01	79	852	2011-02-22 16:17:28	2011-02-22 16:17:28	1	15	295	0	572	795	24	93.90	31	24.37	CHANGED	pL+plDA.as..K.s....s-Dh...ph+.ThuGullTlluhllhlhLhhuEhttY..hsst..hpscLhVDp...s............cuc+LcIslsloFPplPCp...hLolDshDsoG-pphc.l.....p.c	................................l+phDA.as..K.s.....--h....p.p..TtuG..u.h..............lolls.hllhhhLhhsEhttY..h.s.st..hp..clhVDp...s...................pupcl.cINlDlohs.thsCp............hls.lDlh.DhsGcppht...h................................	0	213	335	474
+13693	PF13851	GAS		Growth-arrest specific micro-tubule binding	Coggill P	pcc	Jackhmmer:O95995	Domain	This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localisation of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages [1]. Gas8 is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells.	30.00	30.00	30.00	30.60	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.31	0.71	-5.12	31	204	2011-02-22 16:46:04	2011-02-22 16:46:04	1	7	130	0	133	196	5	187.80	36	41.80	CHANGED	spLhcpH-pAFp-hKsYYN-ITpsNLplIpoLK--ltph++p-pcsc+hht-lpp-N+cLsEPLppspp-lpcLc+pLppYp+DKtsLppsKs+lpphccclpsLchEp-lLpp+applppER-pLhp+Fcpslp-lpQKsth+NhlLEpKlpslpcpLEp+-spLpcllpsssl-ss.tlptlspclccllpsKNptIcsL	.............................pLhppHEcAF.......s-hK...........sYYNDIThNNLsLIpoLK-phpch++..p-p+.-+.ht-lttc.N++Ls-PLpcApc-hp-Lp+pLt..p.Yc.+........DKp..tLtssKs+lp..hh.ccclcsLpWEpElLppRapc................lppE...R--Lhp+F....p....ssl.-lQQKsuhKNllLE+KLpsLpptlEp+-sQLsElLssusl-Ps.slp.l.s.......p+lcclLppKNptIccL...........................	0	57	72	108
+13694	PF13852	DUF4197		Protein of unknown function (DUF4197)	Bateman A	agb	Jackhmmer:C7PG16	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 228 and 249 amino acids in length.	24.90	24.90	24.90	38.90	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.68	0.71	-11.04	0.71	-4.78	102	258	2011-02-22 16:53:23	2011-02-22 16:53:23	1	3	244	0	119	277	75	201.50	38	83.83	CHANGED	ssusLossphssG.LKcALphGsppAVspLupp...sGFhsNstl+I.LPppLpcssphL+pl..Ghu...phsDchhhshNRAAEsAsscApslhhsAl+pMolsDA+sILp.Gu.-sAATpYhcppTpspLtspFtPllppuhsclGssphasslh.........................s..ph................sslsh....spp....hss.sLssYVTpcAL-GLFthlApEEppIRpsP.supsosLL++VFG	......................sh.ssLops-hsuG.LK-ALspGsptAVspLups...sGFhsNstV+I.LP..sp..Lp.cssphl+ph.....GhG.........s.sDpl.tuhNRAAEsAVspAp.slhlcA.l+pMols.DA+sILp.Gu.csAATpYLcppopppLtscFhPlVcpuhsc.....VG.....hsptYsshs......................s.ph...................sslsh...........lss..hsssLpsYVTpcAL-GLFphlAccEppIRpsP.supsTsLL+KVFG.....................................	0	47	98	113
+13695	PF13853	7tm_4		Olfactory receptor	Coggill P	pcc	Jackhmmer:Q9H342	Family	The members of this family are transmembrane olfactory receptors.	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.99	0.71	-4.39	118	25558	2012-10-03 04:04:29	2011-02-23 09:06:22	1	29	180	0	14828	27096	3	143.20	33	48.90	CHANGED	sssthhsuus..hsuGhLp.ul.l.HT..us.TF...sLshC...p..s.s...c...p.Fhs-hPt.lLK.LSCS-o.al.pEl..slllhus.hlshssFlhIllSYlpIhpAVLRIPSppGR+.KAFSTChsHLsVVSLFhuTshFsYL+P.s......Shu..SsshDlll....oVLYoVVPP	...........................................................................................................hChh.L.s..s.s.u..a..h.h..G..h..l..t..u.l...h..p.s.......h.h...hh......pL.s..FCt........sN...h.I.....s..H.Fa.C..-..hs........sl.l..+....L.u.C..u..D..T....t.l...scl...........hh.....h...h...h....u.s.....h..h.hhh..........s..h.h.h.I..l..h.S.Y.s...h.I....l.t....s.l.......L..+...l...t......S...s.....p.......G..R.p....KA.F....S.TCu.S...HL.s.VV.s.lF....YGss.l...h..h.Y.lpP..p.......u.s.p..............s.........p....h....cplh......ulhYollsP.......................................................................................................	0	416	451	1888
+13696	PF13854	Kelch_5		Kelch motif	Coggill P	pcc	Jackhmmer:A8MU55	Repeat	The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif.  It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet.  Several of these sheets associate to form a beta propeller structure [3] as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.	27.00	20.00	27.00	20.00	26.90	19.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.56	0.72	-8.12	0.72	-3.94	78	1509	2012-10-05 17:30:43	2011-02-23 09:06:54	1	435	312	0	1094	6146	187	42.50	25	6.40	CHANGED	hP.ss..ptp.tss.s.....h.s.....s.............tp......lal...aGGhs...........psps..h..s.cla...lL...slss....h	..................................................P..s..Rhs.Hss.s.......................s.h.......s................sp......................l.al........aG..G..hs.............................psth..........h......s.D...la.....hh..sh......................................	0	445	651	900
+13697	PF13855	LRR_8		Leucine rich repeat	Coggill P	pcc	Jackhmer:JCS-Target417241	Repeat	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.36	0.72	-4.21	93	70869	2012-10-02 21:32:02	2011-02-23 12:42:34	1	6305	1468	377	38112	83275	1324	59.50	28	22.98	CHANGED	spLppLpLs..p.N.plp.tl..sp.ssFp.sl...spLp.hLsLs.tNpl..p..sl..ss.p.s...hpsLtpLptLpLs.s.N.p.l	.....................................tLptLp.Ls.......p..N...pl....p...pl...........ss...t..s..Fp....s...L..........sp...L..p...t...L.....s.....L.....s...p......N.....p...l....p........sl......ss...t..s...............h..p...s...L.....p.....p...L..p..t..L..pLs..t.Npl......................................	0	11072	17914	27457
+13698	PF13856	Gifsy-2		ATP-binding sugar transporter from pro-phage	Coggill P	pcc	pdb_2pp6	Domain	Members of this short family are putative ATP-binding sugar transporter-like protein.	22.90	22.90	22.90	23.00	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.98	0.72	-3.85	23	319	2012-10-01 22:58:23	2011-02-23 17:08:29	1	1	266	1	22	351	15	88.50	45	95.50	CHANGED	hsssFDphhupsDssIh..phMGpphpIsG.....tshhuVhD-s.s.ht..............slpGsuhoLslaoushht.P++sDpl..shsGcpahVsRhph.s.GphhlhL	.......................s.Fpthh.tcMDslTl...+c..MG.+.pAsINs.......sshs.VlPsEphAEh.s..............ALSGs...ulSLVV..F....Sus.YR...P+RGDpV..Vac......G..pp....aTVTRa-paN..GKPhIal.................	0	5	9	17
+13699	PF13857	Ank_5		Ankyrin repeats (many copies)	Coggill P	pcc	Jackhmmer:P42771	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.76	0.72	-3.57	81	5157	2012-10-02 12:10:21	2011-02-24 13:31:59	1	1642	768	6	3250	58643	3660	54.20	29	7.93	CHANGED	Llpps...shtt.sttt....ssLthAsp.tsphphlphLl....t.thshphpstps.tsslchA	............................................t...ss.hst.p..s...p.p.Gp...............TsLHh...A.u.....t..p.....G....p....h....c......l....lchLL............pt..G.A.c..h....s.h..psp.pG..pTsLphA.............................	0	1425	1883	2549
+13700	PF13858	DUF4199		Protein of unknown function (DUF4199)	Bateman A	agb	Jackhmmer:C7PPF0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 167 and 182 amino acids in length.	27.00	27.00	27.10	28.80	26.60	26.20	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.20	0.71	-4.32	97	280	2011-02-24 17:30:07	2011-02-24 17:30:07	1	1	202	0	108	296	198	157.40	18	90.11	CHANGED	paGhhhGlhhhl..hhllhhhhh....s.ths.t.hh......shh..hllslshh...hhul+pa+pphhsG.hhoatpuhthGhhhshluullhslhphlahphl..sPsahpphhptt..t...t....ht.s.t.hp.t..htth...ht..t..t..............hthhh.shhtslhhGhllollhuh.lh+..pp	........................auhhhGhhhhl.hhlltahhh.h.....shphshhshl.....shh...hllslhhh...........hhtl+paRp..p..h.hsG..hloatcuhhhuhhhhhhuullsslhpala..hphl..-s.sahtphhpth.hp............t....htts.thhp..tth.pth.....th..p.hps.......................hphsh..hhhtslhhGhllulhhuh.hh++.......................................	0	50	93	107
+13701	PF13859	BNR_3		BNR repeat-like domain	Coggill P	pcc	Jackhmmer:Q99519	Domain	This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.31	0.70	-5.36	201	1305	2012-10-02 00:45:24	2011-02-25 12:47:17	1	12	39	1	486	2085	72	273.70	35	44.51	CHANGED	sPuLlcV.suDVFAVAEAQhp.pp.........................ps...s....s............t...........................st...h....u..htp...........tt....tpt.p....p................p.....p.p.t.hh.cs.........s.......................................p...pp......t....+..............Vs..ls.RPTsllc...Gs..DIYML.............s.....Gp...Y.S.............pp...s...................us.....s.......................sh.s...lh.....................Ls............c........us.....s....s..sp......p.......Wp........................-spsls.......psh.............t..p..........................p......h............LlGGG....GSGVKMc....DG.TLVFP............VE............GT..........KK.p..sstt..........sVSL...IIY.S..pc.....sp...sWpLSKGMSs...........sGCSDPSVVEW...c-...t.KLMMMTACDDG....RRRVYESGDKG-SWTE.......ALGTLS.........RV.WGN..............p............hpushlsut............ss.-....pRs.....VMLVTLPVa......ttst......spc........KGcLHLWL......T..DNTHIVDIGPV.s..pD..D..D.sAASSL.LYKSup........s.sspcEELIALYE	..............................................................................................................................................................................PuLlps..sus.lh.AhA-uphttt.......................tt...t..................................h.hs.t..................s.t.t...p............pt.......h...tt..t...........................................................................................................................................................t.t.t.p...............s.t..l.....p..PT..s.h..sp.....ss.........pla...h...L..............s....Gp....a.s..........................ppt.................ttt..............................................................ph.slh...............ls...........c..........sp....s..tt....p...........Wp......ps..ts.l......t................p...................................................p.......t........h.lu..uG.G.SG...l.h.hp.......D.G....TL....V..FPlp............ut.............ppt...tt..................h..Sh....lha...o.p.s.......s..p...s...W..p...l.o....p....s.ho.s.......................sG....C..t...sP.sl.sE..W.......c.....t....c.....L.h....M.h.........s..s....C.c...s..G...........p....p+.V..Y..E.S.s.DhGpoWT..E.....Al..G..T.Lo..+V..Wu..s...pp............t.tuthlpu.............ss.-.t+pV.ML.hT..sh.......tpt......tpt.....cstL.aLWl......T.DN.....s+.hhslGP.....l.....ts...-...s.s.s....A...S..o.LLYpsst................hh.......................................................................................................................................................	0	14	25	486
+13702	PF13860	FlgD_ig		FlgD Ig-like domain	Bateman A	agb	Bateman A	Domain	This domains has an immunoglobulin like beta sandwich fold. It is found in the FlgD protein the flagellar hook capping protein. THe structure for this domain shows that it is inserted within a TUDOR like beta barrel domain [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.80	0.72	-4.24	102	1909	2012-10-03 16:25:20	2011-02-25 14:24:35	1	97	1529	5	465	1365	1800	80.40	26	23.53	CHANGED	usth..........hsss............tsshp..Lsssusss..plpltDs.sGplV..pshsl...sspsu..GthsasWD.GpsssGp.....................tlssGp.Yslpl..........pu.psss	..........................sttsss.........sss.....tshslp..L.tp.su..s....p..l....slp.IpDp.sGplV........+T.l.s.l............G.s.h..........su....G.s..t......s.....Fs.....WD....Gp.s.ssGs...................................sh..s.s..Gs..Yslplsusst.t.................................	0	162	299	386
+13703	PF13861	FLgD_tudor		FlgD Tudor-like domain	Bateman A	agb	Bateman A	Domain	This domain has a tudor domain-like beta barrel fold. It is found in the FlgD protein the flagellar hook capping protein. The structure for this domain shows that it contains a nested Ig-like domain within it [1].  However in some firmicute proteins this inserted domain is absent such as Q67K21.	26.90	26.90	26.90	26.90	26.80	26.80	hmmbuild  -o /dev/null --hand HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.00	0.72	-3.97	107	1425	2011-02-25 14:57:41	2011-02-25 14:57:41	1	6	1242	5	295	834	103	141.10	27	59.41	CHANGED	sspshpuuuhlG+pVhssus.th..........tsss..................tsshp..lsssusss....plpltDu.sGplV..pshsl...sspsu..G.hsasWD.....GpsssGp....................tlssGp.Yslpl..........pu.psss.....tthshsshstupVsuVphs..u.sss.hLsl.ssst.....lshsslpplt	.............................ssQuLQAosLIG+sVhlsGsslhhssssptsussthsstssphttssspsssslssp...........................................................sluphsuGspshsWsGppssGsssssGpYshshsusssGsphsspshthuhVpuVhhs....u.sss.hLsL.Gshut....ssLscVppl.h.............	0	63	154	224
+13704	PF13862	BCIP		p21-C-terminal region-binding protein	Coggill P	pcc	Jackhmmer:Q9P287	Family	This family of p21-binding proteins is important as a modulator of p21 activity. The domain binds the C-terminal region of p21 in a ternary complex with CDK2, which results in inhibition of the kinase activity of CDK2.	20.70	20.70	21.50	25.50	20.40	19.50	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-11.30	0.71	-4.80	87	360	2011-02-28 11:44:46	2011-02-28 11:44:46	1	3	298	0	238	367	11	198.30	28	65.46	CHANGED	-h..lsVDF-hasss.s.sDaHulKp..LLpQLhs...s...sp..hsl.up.........LuDlIlsQ......s...s...lGoslKs............................Ds..c....-.......s.-sau.hlollNlppp.................p...s..p.....slcpLtcalhp+sp................sps.hh....ppLpplLs.............s.s..sp....p......lGLllsERhlNhPspllPPhaphLh-ElptAtp........cp...............c.aphs.aaLllo+sY...........................cp.................tp....ttp.ptt..ttp...pp.................................................sE.......hhah+sEDEhht	.............................-.VslDF-has.p.s.sDacGlKp..LLpQLa....p.....s..hsh.up........................LsDLIlpQ.......sp...lGoslK....................................Ds..c-...............s-s...au.hlolLNL......ppp.......................+...s..p.....slpplpcalhppsp.......................pps.hh....ppLpplLs...............................ss....sp....plGLlloERhlNhPsplssPhap.Lh.cElptAhp........sp....................csaphs.aaLllo+sa......................................pc.....................tt.....ttp.p.pt..ppppp............................................pc.....hhahpsE-Ehh................................................................................	0	82	134	194
+13705	PF13863	DUF4200		Domain of unknown function (DUF4200)	Coggill P	pcc	Jackhmmer:A6NFT4	Family	This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.	28.90	28.90	28.90	28.90	28.70	28.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.52	0.71	-4.18	69	384	2011-02-28 13:40:14	2011-02-28 13:40:14	1	8	119	0	261	380	4	125.20	24	29.05	CHANGED	phlcp+REhhphpptlcpp+.cch...pcppcthpp+ccplpcpppcLpcphh.caspFlp-scsK+pcA.+chppEpptcpphpp-lpclppplspLpppppclcpp.lpphp.YpcaLcp.........Vlp.......tss.......p.......app	......................................hlpc+R-hhhhphsLptK+.pch........p+hppthpp+ccpLppp-ppLccchh..pF-cF...lc....-N-p+phcAh+p....ApcEpct+tp+ptElcclptplptlc.schp+hcpp.lpch.........phYpcaLpp....ls.p.....................................	0	133	157	201
+13706	PF13864	Enkurin		Calmodulin-binding	Coggill P	pcc	Jackhmmer:Q8TC29	Family	This is a family of apparent calmodulin-binding proteins found at high levels in the testis and vomeronasal organ and at lower levels in certain other tissues [1]. Enkurin is a scaffold protein that binds PI3 kinase to sperm transient receptor potential (canonical) (TRPC) channels. The mammalian transient receptor potential (canonical) channels are the primary candidates for the Ca(2+) entry pathway activated by the hormones, growth factors, and neurotransmitters that exert their effect through activation of PLC [2].  Calmodulin binds to the C-terminus of all TRPC channels, and dissociation of calmodulin from TRPC4 results in profound activation of the channel [3].	23.00	23.00	23.00	23.70	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.26	0.72	-3.79	54	314	2011-02-28 14:56:46	2011-02-28 14:56:46	1	5	133	0	205	315	3	96.40	26	32.90	CHANGED	G...clPpYLpcpKc.chtcp..pc......phcp.h.tc.p......ts......suhphlsEcERhphLpsL+pphcplppchp.plshh..hD.Thst+pRKpclEccLpplEcsIchhs+spV	....................................................GplPpYLh.cp.+c.phpct..pc................th.pp....tc.t............t.........................suhphls-pERtphL...psL+pphppltp-hp.plshh..hD..Tltt+p+KtclEccLpplEcsIphhp+.p..................	0	92	109	161
+13707	PF13865	FoP_duplication		C-terminal duplication domain of Friend of PRMT1	Coggill P	pcc	Jackhmmer:Q5T7Y9	Family	Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it colocalises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.19	0.72	-3.54	26	408	2011-02-28 15:48:16	2011-02-28 15:48:16	1	13	203	0	273	388	0	70.80	26	28.25	CHANGED	ss.............tssptGphp..tsptsttG+sRu+ssRpspsttt...tsthopE-LDtELDpYM.......ussKscLDt-L-sYhpttt.p	..............................................................................................ttstt......tGtht.....tupsstsupupu+....utpt...s.p.uttpt.....c.thosE-LDs-LDsYh...........st...................t.....................	0	89	131	201
+13708	PF13866	zf-SAP30		SAP30 zinc-finger	Coggill P	pcc	Jackhmmer:Q9HAJ7	Domain	SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two beta-strands and two alpha-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure revealed a highly conserved surface dominated by basic residues. NMR-based analysis of potential ligands for the SAP30 zn-finger motif indicated a strong preference for nucleic acid substrates. The zinc-finger of SAP3 probably functions as a double-stranded DNA-binding motif, thereby expanding the known functions of both SAP30 and the mammalian Sin3 co-repressor complex [1].	25.00	25.00	29.30	28.60	19.40	17.10	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.86	0.72	-4.33	5	123	2011-02-28 17:15:49	2011-02-28 17:15:49	1	2	78	2	78	124	0	71.50	65	39.79	CHANGED	PuAAGPtsGQlCCL..RE-GE..RCGRPAGNASFSKRIQKSISQKKVKI-LDKosRHLYICDFHKNLIQSVRN+RKRKsSD.D	...........................h.sQ.CCL......l-DGE..RCsRsAGNASaSKRIQKoloQK.KLKLslD+SsR.HLYICDaHKNhIQSVRNK.RKRKsSDDt..................	0	18	23	45
+13709	PF13867	SAP30_Sin3_bdg		Sin3 binding region of histone deacetylase complex subunit SAP30	Coggill P	pcc	Jackhmmer:Q9HAJ7	Family	This C-terminal domain of the SAP30 proteins appears to be the binding region for Sin3.	22.20	22.20	22.90	22.20	21.50	20.20	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.05	0.72	-8.56	0.72	-4.09	36	333	2011-03-01 09:59:32	2011-03-01 09:59:32	1	8	234	1	224	313	0	51.20	37	25.43	CHANGED	LpsssL......+RYp+.taplstt...sssK.pQLspsVt+HFpots.lsEp-sIstFlhtl+	.....................LphssL......pRYp+..capltsps...shsK.sQLspsVp+HF.ps.h..s..lsE.p-slshFlYtVK................	0	62	112	168
+13710	PF13868	Trichoplein		Tumour suppressor, Mitostatin	Coggill P	pcc	Jackhmmer:Q8NEH6	Family	Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement.  The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs) [1].	27.00	27.00	27.50	27.50	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-12.75	0.70	-6.05	68	564	2011-03-01 11:50:10	2011-03-01 11:50:10	1	11	126	0	380	548	18	306.30	19	64.55	CHANGED	-pp-El+pLppplptAtssp.RssQltE+cthctcpp.cc-pphsphhct-+p+slpppcccEppctpcptctpptlppQl.cE+cpp+tpptcphtpEcphhpphhcplp-E-ptct.tc+pc+ppphtc-lpchpcpptphKctpcpppccE-p+.lhcahppppc+ccphppcppct.ccc.+-chhp+Ltpp.pctpccpp-h-pLptchhtEEtccct....Rp+-pp-tcc+tchpp-lppscppQhptKppphptptpc-cpphpchlp.phtcpcch-phptpc++tpp.catcplpptlpp+cpp+pppcppphp-tpphp...cppppcpphl-ptR.p+hLpchtsp..shhsK	..................................pppcl+phpphlhtspsht.RssQlt-+p.thptp...pt.pc-p.thtph.hctcpppthpcppppcppcppcph....phtptltpQl.pcp.cpp.+t.tt....tcp.pppEtp.hpp.hhcph.p.t....E-.ppct..tp+t.ppppphpptlpch..pppt..ph+pp...ptpppppt-p+.lhph.h..tpc..pp....c...cp.ph....p....t.cppch....ppp..ppth.h.p....t.l..tp.t..p.c..p.pp.p.t.ch-plht..chhtcphpcc..........cpct...p...p...ctp.p+.chhpc.lhpsctpQht.Kt...pt...h...ttpt...tc...ptt.....hpphhp....t.pp.tpc.cp.ptpcpp...tht.phtptlppp....lppppppt.tppptphpch...p.t.t....p..ttt..pthl..pp.h....................................................	0	166	202	285
+13711	PF13869	NUDIX_2		Nucleotide hydrolase	Coggill P	pcc	Jackhmmer:O43809	Domain	Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, di-nucleoside and diphospho-inositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity.	27.00	27.00	27.40	27.00	26.80	26.30	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.12	0.71	-4.97	25	336	2012-10-02 00:00:35	2011-03-01 14:52:41	1	6	247	29	220	316	2	175.50	52	74.87	CHANGED	pslplYPL.oNYsFusK....-shhc.KD...tolscRhpRh+ssYpppGh.RpoVcullLVHcasaPHlLLLQ.l...sss....h.....aKLPGG+L+sGEs-.l-GLKRKLscpLu..............ss......c..sh...................pssWclG-slGpWWRPsFEs.hYPYlPsHIT+PKEppKLalVpLPc+stFtVPKNh+LlAlPLF-LasN.tpYGshISulPplLSRF	............................................p.slplYPL.oNYTFGoK....Es..E.cD.........sSVsuRhpRhc-cacc..hGM..RRoVEGVLlVHEHshPHlLLLQ.l...uss......F....................FKLPGG.cLpsGE-...............E.lEGLKR.hLs-pLu...............t.....s....uh...............................tp-W.ls.DslupWWRPNFE.s.....YPYlPsHl..T..+..PK......EpKKL..a...lVpLsc+.........thhu.V......P.K.NhKLlAsPLFELYDNsttYGP.lSulPplLSRa.........................	0	77	118	173
+13712	PF13870	DUF4201		Domain of unknown function (DUF4201)	Coggill P	pcc	Jackhmmer:Q2M329	Family	This is a family of coiled-coil proteins from eukaryotes. The function is not known.	27.00	27.00	27.00	27.30	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-10.97	0.71	-4.83	56	290	2011-03-01 17:10:52	2011-03-01 17:10:52	1	9	106	0	186	284	10	165.80	24	35.01	CHANGED	hppp.csplschRLphlphpcplschppplcphEplu-s...LphhDF.plph-stsLscKIEERNp-Lt+L+pphspslphlsHh+cKhp.......hlppphpph+ppLpctpcphpclRcplhpschc+s+lcppppc..L+ppuulhphPsLhtD.Y-pphpplpphccslcpL+c..phcplptplpt	..................tppcp.hschRLc.hplcppht+hptplcpp-plu.-s...LphlDFpQL.cI-Npphtc+IEER.N.....pELhcL+.tp........sspsl............phlsph+..............cKhp................hhtpc.pphcpcltptpc.ltchcccltpsctp+pphcppppc.L.cpptuh...h..th......Pplh.-.a.pphtphtthcpplpthcc..chp.hphph..t............................	0	83	104	145
+13713	PF13871	Helicase_C_4		Helicase_C-like	Coggill P	pcc	Jackhmmer:Q9Y2G9	Domain	Strawberry notch proteins carry DExD/H-box groups and Helicase_C domains. These proteins promote the expression of diverse targets, potentially through interactions with transcriptional activator or repressor complexes [1].	27.00	27.00	27.20	27.30	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.83	0.70	-11.82	0.70	-4.98	47	482	2012-10-05 12:31:09	2011-03-02 11:29:27	1	25	252	0	257	484	56	240.40	40	21.03	CHANGED	ssLDpllpchG..sc.tVAElTGRptRl...Vpp.p..sG....p.hthcpRsss...........sNlsEppsFMsGcKtlhlhS-AGuT.....GhShHADhpstN.Q..RRRVHhhLEhsWpADpAIQthGRTHRoNQsssPhac.lsTcltGE+RFhSolA+RL-oLGALT+GpRpsusp.h...................h.up.Nl-osYu+p.ALcphap...tlhtsp....h.............................h................tFhpch.puLp.l.l....................ps.psG.......shp.-.....c......s..sIspFLNRlLuLslchQNsLFphFpphlpshlcpA+tsGp..aDhGlps	..................................................sLDpllpphG..s-.tVAEh.....T.GRptRl....Vpp.s....cG....................p.lhh-sRstt.......................hNhtEpptFMsG.c..K..........tlhIh.S.-Auuo.....GhShpA......Dtps....pN...Q....R+RVH................hhLEhsWpADpAIQth...GRTHRoNQss..s.P..ah..hlho-l.tGE......+.RFsShlA....+RL-o..LGALT..+GpRcsstp...h...................h.sp..Nh-spYu+p..ALcthhp...tlhttp....h................................................................................pFh.p.ch.tuLhtltl..............................t.pss..........hhp..-.....c.........sIspFLNRlLuhtlchQNt.LFphFtphlsthlptA+ttGp..aDhGl.......................................................................	0	88	144	201
+13714	PF13872	AAA_34		P-loop containing NTP hydrolase pore-1	Coggill P	pcc	Jackhmmer:Q9Y2G9	Domain	\N	27.00	27.00	27.10	28.30	24.30	23.30	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.09	0.70	-5.65	39	492	2012-10-05 12:31:09	2011-03-02 11:38:16	1	21	227	0	281	484	52	270.10	45	24.25	CHANGED	utsHP.ssLVESuuMASVuPPtso....Yp...pLPstlls...sGhLSssQLEoVlYAupAHsthLsGta..tt.............t..th..RpGFaLGDGTGsGKGRQlAGIIhDNalpGR+RAlW.lS+SssLlEDAcRDWpslGut..thplhsLu+............................a+.u......cs......s......h......pc......GlLFsTYuTLRus.....t.t....ttctSRLcQllcWhG.p-.............FDG.VIlFDEsHthtN......A......u......uut.........tsSpQGhAGLcLQptLPcARVlYsSATGAoclcNLAYhsRLGLWG.ts.t..PFsstpsFlsAl-pGGlAAMEllARDLKAhGLYlARuLSFcGVEa-llEppLTp-QlplYDsa	.......................................................h...HP.s.lVEouu...h.u..........SVsPPc.t....Yp.....tlst.....thhp..pGhL.SshQLEslhYAspt.Hpt.hL.ssu...........................................R...tGFhlGDGsGlGKGRplA....GlIh-Nal..pG.R.+..+A.............lW.hSh.....SscLh....D.ApRDhp......slG...up....pl.lpsLs+..............................................................hc.u.......c..........hs......h......pc.....G..l...lFsTYu..sLhup.......t.....................tphpoRlpQll....pWhG...pc................................FDG..V...I.lFDE.....sHphpN.....h...s.stt....................tsoppGhAsLcLQ..............ptL.PpAR.V.VYsSATG.A.o..cs+Nh.u.Yh.sR.LGlW................G..ts.t.s.Ft.p............htcFlpAlE.......c..t.G.....VuAMEllAhDhKhpGh..YlA.RpLSFp.GV.pacl.Eh...Ls.......p.hphYst.t........................................................	0	102	162	224
+13715	PF13873	Myb_DNA-bind_5		Myb/SANT-like DNA-binding domain	Coggill P	pcc	Jackhmmer:Q8NCY6	Domain	This presumed domain appears to be related to other Myb/SANT like DNA binding domains.  This family is greatly expanded in arthropods and higher eukaryotes.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.35	0.72	-4.08	40	544	2012-10-04 14:01:12	2011-03-02 13:50:17	1	24	83	0	347	698	0	75.80	23	22.09	CHANGED	Rp.tpFotpEhplLlchlpcppplLhs+tsssss....hptK.scsWcpIspchNu..hus.s.pRohppl+++WpchKppsKc.chtp	..............................Rt.pao.pEpphLlph.lc.pp..hpll...s+pss.t.s.s.....htt.K.p...csWcpIspchNu......hss..s..p..R....shppl++pWpchKtps+cch..t................................	0	96	119	238
+13716	PF13874	Nup54		Nucleoporin complex subunit 54	Coggill P	pcc	Jackhmmer:Q7Z3B4	Domain	This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel.  The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them [1,2].	30.10	30.10	30.90	31.20	30.00	30.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.78	0.71	-4.52	49	335	2011-03-02 14:23:06	2011-03-02 14:23:06	1	13	275	1	231	340	1	138.80	31	29.89	CHANGED	p..Ps..shs.cpWcpAh......pcpPsP.p....hlPV.hhGFp-LtpRhphQcpplsphpthLpplpsp.lspL.p.p+.chpsss+ltct+p+ptpLp+RlLclhsplp..lL+p+Ghs.........Lss-E-clppclpplppclssP.sth......u+lsEL.......hupl........p	................Ps.ssDsthWcpAh......hcsPsP.p..........hlPV.h.hGFp-LtpRhchQcphspptps+Lc.....t....lspp.ls.........p.......L.p+c.phssss+ltph+c+phpLs+RhLpl.....ht+hp..lh+ppGhu............................lps-EEpLpppLpplppplp..sP...sthp..........uRhpELhuph....................................................	0	77	125	187
+13717	PF13875	DUF4202		Domain of unknown function (DUF4202)	Bateman A	agb	Jackhmmer:A1B4I0	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 187 and 205 amino acids in length. There are two conserved sequence motifs: LED and KMS. The function of these proteins is unknown, although many are incorrectly annotated as glutamyl tRNA synthetases.	21.60	21.60	25.70	25.90	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.19	0.71	-4.64	51	144	2011-03-05 16:24:37	2011-03-05 16:24:37	1	6	142	0	91	151	13	182.80	41	82.94	CHANGED	appAlstIDsApupDPspp...h......p....spshPtELhYup+MochL.............p+hsPs.ASE..............sLpLAsRuQHlcRWclPRusYPhs+sGYhpWRssLtphHAphssplh.....hpuGYsppphpRVutllcKcsl.....K......p.............Ds-sQsLEDVACLVFL-chhtsFsppH...D.--KllcIlcKTWtKMS-cG+phALp..lsLs-phtsLlt	..........................ppAlthIDtApspDPpt...h..........s..spshPhELhYAp+MocaL.............tph.pP.s....A.....S-..............hLp.LAsRuQHlcRWclPRssYPhsRs.GYhpWRssLtptpAspssclh.....hpsGYspp-hpRVusLlpK.csL......K..p..................Ds-sQsLEDVACLVFL-c.Fp..pFtpc+.................D--KhlsIlcKTWtKMSpcG+phALp..lp..hs-phttLl.t....................................	0	23	57	76
+13718	PF13876	Phage_gp49_66		Phage protein (N4 Gp49/phage Sf6 gene 66) family	Bateman A	agb	Jackhmmer:A1B8I7	Family	This family of phage proteins is functionally uncharacterised. The family includes bacteriophage Sf6 gene 66 Swiss:Q716B1 as well as phage N4 GP49 protein Swiss:A0MZD7. Proteins in this family are typically between 87 and 154 amino acids in length. There is a conserved NGF sequence motif.	27.00	27.00	29.70	29.50	25.10	24.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.62	0.72	-3.91	52	176	2011-03-05 16:37:05	2011-03-05 16:37:05	1	4	160	0	15	139	2	88.40	41	69.80	CHANGED	+lT.ppl-shIsppp......Yhsttst...................................plTlCslsLcNGFpVs.GcSAC.lsPpNFDsElGcclAcc....sAhsKlW.LEGY..hL+ppLt	......................+lT.ppI-ulItppp......Yhstts.sh..................................hlThCllsLcNGFsVs..GcSAC.ssPcNFDsEIGc+lA+p....sAhsKIW.LEGYhLppph.t.......	0	4	8	12
+13719	PF13877	RPAP3_C		Potential Monad-binding region of RPAP3	Coggill P	pcc	Jackhmmer:Q8IW40	Domain	This domain is found at the C-terminus of RNA-polymerase II-associated proteins.  These proteins bind to Monad and are involved in regulating apoptosis.\	\	They contain TPR-repeats towards the N_terminus.	23.00	23.00	23.50	23.90	22.90	22.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.81	0.72	-4.01	50	325	2011-03-07 13:33:25	2011-03-07 13:33:25	1	54	161	0	200	314	1	93.70	25	18.61	CHANGED	.ss.Ppsuh-Ftpsa+plt..t......sss........tphpaLppl....ssssLsplFps.slss-hLtpllpslp.....ph...hh.pc....p.s.....hshphLptLscspRFchhl.hhluss-Kp	...........................PpsuhcFtpsa+plt..s........sss..........tphphLppl.......sPsplsplFps.sLsschlspllp.sLp.....................sh...hh.p-.....................t.s................hlhphLppLupspRF....shhl.hhhSps-K...........................	0	70	97	145
+13720	PF13878	zf-C2H2_3		zinc-finger of acetyl-transferase ESCO	Coggill P	pcc	Jackhmmer:Q5FWF5	Domain	\N	21.70	21.70	21.70	22.30	21.20	21.50	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-8.14	0.72	-4.39	43	338	2011-03-07 14:47:26	2011-03-07 14:47:26	1	11	245	0	223	333	2	40.40	39	8.27	CHANGED	QhhLDhGQpp.h.s.t.p.pCspCGMhYssuss-DpphHp+aHpph	.............QhhlDh..G.Qcp...hs.t...h.pCspCGMhYssu.ssEDct.HppaHpp....	1	57	100	161
+13721	PF13879	KIAA1430		KIAA1430 homologue	Coggill P	pcc	Jackhmmer:B2RV13	Family	This is a family of KIAA1430 homologues.  The function is not known.	23.00	23.00	23.30	23.00	22.80	22.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.00	0.72	-10.42	0.72	-3.57	46	280	2011-03-07 14:58:15	2011-03-07 14:58:15	1	16	112	0	222	284	2	98.40	23	30.14	CHANGED	tH.pp+lpph+...s........slcsps.......Ppp.ht.......phh...hphpph.phpp.........p+h......pcIp+....-NphLlp+ls..cIt.cppsph...stp.p...........ttp................csls...tp...pRpcE.ht+...IscENpplh+Rlpp	...............................chp+l.php...s........tlDsp.........Ptt.ht......thh...hp..h+ph..phpp...............-+hppI-+....-NphLLp+lsplt..cptsph....sph..pp..........h..................................................pshs....t.pRp+c..t+...IptEN...tlhcRlp.h........................................	0	119	142	181
+13722	PF13880	Acetyltransf_13		ESCO1/2 acetyl-transferase	Coggill P	pcc	Jackhmmer:Q5FWF5	Domain	\N	21.60	21.60	21.60	21.80	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.08	0.72	-4.23	40	326	2012-10-02 22:59:21	2011-03-07 14:59:05	1	6	233	0	213	325	10	69.20	42	14.58	CHANGED	shsAhCGlsRIWVpsppRR+GIAocLlDslRssFl.aGhplspsplAFSpPTssGpthAppYsss....ss..FLVY	......sAlCGISRIWVhshtRR+uIAo+LlDsl.Rs..s.Fl.aGthl.........s.........+p.....plAFSpPTssGphhAppYsss....sp..ahlY......................	1	57	94	154
+13723	PF13881	Rad60-SLD_2		Ubiquitin-2 like Rad60 SUMO-like	Coggill P	pcc	Jackhmmer:O95164	Domain	\N	23.00	12.00	23.00	12.00	22.90	11.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.50	0.72	-4.18	24	319	2012-10-03 10:59:06	2011-03-07 16:02:45	1	4	202	3	206	1807	27	106.70	29	62.84	CHANGED	-.lElKFRLs..DGoDIGPhpass.uoTVusLK-pllu.pW............P+-..Kcp.sP+oss-lKLIsuGK.ILE.NN+TLups+..hPhG-lss...slhTMHVVlp.shs-ppsc+p.....psc..s.+pspCsCs	....................................................lpl+hhLh..sGp..ht...hh.ass..ssolsslKcplhs..pW.............................................Pp.-.....hct....ts..p..osst..l+L.I.tG+..hLc...sst......TL....uph+....hshscs.....................slMH.lVs+....s...sc..psptp...........tpp.....t................................................	0	54	105	159
+13724	PF13882	Bravo_FIGEY		Bravo-like intracellular region	Coggill P	pcc	Jackhmmer:C9J6A4	Domain	This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY.  The function is not known.	23.80	23.80	25.40	24.40	23.60	21.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.22	0.72	-3.07	19	521	2011-03-07 16:52:03	2011-03-07 16:52:03	1	69	100	0	165	423	0	86.90	55	7.65	CHANGED	KRs+GGKYs..V+-KEss.pscs-sp....p-..ssFs.........EYpp.ps..sp.sh.p....tupts..stphpsp...sosDShs-YG.-u..ss.spFNEDGSFIGQYusc+cp	............+Rs+GGKYs....VKEKEDs.psDsEhps..hcD...soFs.............EYS......-.....ED.....cK.PLtt.....................uSpss...st.slKtp...............cSDDS.LVDYG.-G..sp.GQFNEDGSFI...GQYouKK-K................	0	29	43	97
+13725	PF13883	Pyrid_oxidase_2		Pyridoxamine 5'-phosphate oxidase	Coggill P	pcc	Jackhmmer:Q8IUH2	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.12	0.71	-4.49	37	676	2012-10-02 11:35:36	2011-03-07 16:55:50	1	10	508	4	389	722	172	156.70	25	61.64	CHANGED	Ps.tc-sAphARhLVppssausluTl..So.......ps.....hpGhPasslhShuDsss...s...susGsPaahLosls.ospslpps.sp..sSloho.sp..............pshspp.........hDPpsP........s.Cs...RlplsGplppl....s......sp-hph..A.ccshhsRHPchppW.ps......HsaaahKLplpsIallshFGG...sphl...ss--Yap	..............................................ARpLlpp..sp.hu.sLuTl......sp............t.............................hpGhP.au.s.hl.shu....................s....sssGpPhhhlS..sl.u.....ps+NL.tss...s+.....sSLhls.tss..................................................................tsss.................................................t.ss...RloLhGphp..l....s.............ssphtt.....s..cpp.ah.ppH.P..c..upha.hsh........tcFtah+l.p.lpp.lh.hluG.FGt...hthl...sspp...t....................................	0	100	209	301
+13726	PF13884	Peptidase_S74		Chaperone of endosialidase	Coggill P	pcc	Rawlings N	Domain	This is the very C-terminal, chaperone, domain of the bacteriophage protein endosialidase. It releases itself, via the serine-lysine dyad at the N-terminus, from the remainder of the end-tail-spike. Cleavage occurs after the threonine which is the final residue of the End-tail-spike family, Pfam:PF12219. The endosialidase protein forms homotrimeric molecules in bacteriophages [1]. The catalytic dyad allows this portion of the molecule to be cleaved from the more N-terminal region such that the latter can fold and presumably bind to DNA.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.88	0.72	-3.84	244	1011	2011-03-09 16:45:01	2011-03-09 16:45:01	1	59	650	2	275	946	2602	57.10	29	7.10	CHANGED	SDpRhKpsI.psl.ps..s...................Lsplpp..lpshsa.....pa....h..................................ttttsp.pch..GhIAQ-lpplhPc	.......................SDpRhKpsI..psl..ss.u...................Lcplpp....lph..h..pY....pap.........................................................tpstp..pch..GlIAQ-lpplhP.................................	0	109	164	224
+13727	PF13885	Keratin_B2_2		Keratin, high sulfur B2 protein	Coggill P	pcc	Jackhmmer:Q6L8G4	Family	\N	23.00	10.00	23.00	10.00	22.80	9.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.60	0.72	-10.95	0.72	-4.24	95	2411	2012-10-03 03:07:01	2011-03-09 16:51:25	1	24	43	0	981	3770	23	46.10	43	80.47	CHANGED	CCpPs.CCpsoC..CpsoCC.pP..oC...CpsoCC..p.soCCpP.sC....Cp..ss..CC.pPs	..................................CCp.ss..C.....C..p..P..o..C.......C.p.....s..o.C....C.pP.....s.C..........C.p.s....s..C.C.....p...s.....s...C....C.......c.P....sC..........Ch.......ss....CC.ps.............................................	0	183	188	227
+13728	PF13886	DUF4203		Domain of unknown function (DUF4203)	Coggill P	pcc	Jackhmmer:Q9NS93	Family	This is the N-terminal region of 7tm proteins.  The function is not known.	29.20	29.20	30.10	29.50	29.10	29.10	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.66	0.70	-4.87	33	330	2011-03-09 17:08:44	2011-03-09 17:08:44	1	7	171	0	235	299	5	186.80	25	38.80	CHANGED	sllsslhs.lhGllhshhGaRha+shh.Fl.....sGahhuuhlshllh....hphps.........hssththtsshls.GlssGlllhhl.hshh.hshGlhhhGllhGhhluhhhhhshhsph.hhhp.s.hshh..h..h..hhshullsul..lsLthp+.hhsIluoulhGushlhhulDhFhps.tlp.hh.htlhtphhsps..h.thh.shPhsh.........salhLusasllhlhGlllQh+	..................................................t.lhsshhh.lhGlhhshhGaRhh+shh..Fh.....sGhhhuuhhh.hl...Lh.....hp.ps................htpph...htsshhsulhh...Gl.hhshh..hshh.hshulhhsGllhGhhlu.hhh.h..h.h..s.th....p.s.s.hsh.h...............sh..hhshull..hsl..lsl.th.+...hhsll.uoulhGushlshulDhahps...l...h.h.lh................tc.h..p.....h.th........s...Phsh..............hlhluhhshlslhGlhhQh+......................................	0	82	113	176
+13729	PF13887	MRF_C1		Myelin gene regulatory factor -C-terminal domain 1	Coggill P	pcc	Jackhmmer:Q9Y2G1	Domain	This domain is found just downstream of Peptidase_S74, Pfam:PF13884.  The function is not known.	24.10	24.10	24.10	26.90	24.00	23.90	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.12	0.72	-7.62	0.72	-4.93	31	153	2011-03-10 11:00:22	2011-03-10 11:00:22	1	9	79	0	92	129	0	35.90	68	3.83	CHANGED	LlVNK.....-RIFMENVGAVKELCKlTssLETRI-c.L.....ERh	.........................LhVNK.................-RIFMENVGAVKELCKLTsNLEoRI-E.LE+W.............	0	24	30	59
+13730	PF13888	MRF_C2		Myelin gene regulatory factor C-terminal domain 2	Coggill P	pcc	Jackhmmer:Q9Y2G1	Domain	This domain is found further downstream of Peptidase_S74, Pfam:PF13884, and MRF_C1, Pfam:PF13887.  The function is not known.	22.10	22.10	22.10	23.10	21.50	21.90	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.18	0.71	-4.38	5	132	2011-03-10 11:11:45	2011-03-10 11:11:45	1	9	52	0	64	109	0	132.00	41	16.50	CHANGED	TIoSIQIlEIQQlID+RYCSsuLpCGPGNYsY+IPVNKaTPTNVKFSLEINTTEPLIVFQCcaTL.GNhCF+uph.....sputsQSpcVstpMTQGYQHIWSLPVAPFpDSTYHFRVAAPDLADCSTDP.as.GpFFTDYFFYFYR+C	.................................................oloSIQlhE.p..IsppYC.ut.s..tCt.......s..G...N..aoYpIPls.ptTP.hp.lploLphNo.o..p..Pl...Vh...Cphs....tp.C.cu...............................uh.p.p..h..c.sp....p..p..TQGh.p....H.hWslslhsFp-.sYHFRVAhs..s....As.CS.o....-s.hh....hTDYaFaFYRhC.......	0	12	16	33
+13731	PF13889	Chromosome_seg	DUF4204;	Chromosome segregation during meiosis	Wood V, Coggill P	pcc	Jackhmmer:Q32MH5	Family	The proteins come from eukaryotes, plants and animals, and are necessary for chromosome segregation during meiosis.	21.60	21.60	23.30	22.10	21.30	19.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.21	0.72	-9.00	0.72	-4.09	23	266	2011-03-10 12:01:03	2011-03-10 12:01:03	1	4	170	0	181	269	0	62.40	45	8.09	CHANGED	ssLRYAlHLRFhsP.................p..............................cpRaYLYssIRVVFspRps..DuDEu.............cL+s.hcaPss.......P..........+Yhsh	...............................................lLRYLlHLRFpss..................p...............................................pGRhYLasDIRllFupRs...-sDpu.............cL+s.schPps.......P.+aSPh...................	0	38	76	124
+13732	PF13890	Rab3-GTPase_cat		Rab3 GTPase-activating protein catalytic subunit	Coggill P	pcc	Jackhmmer:Q15042	Family	This family is the probable catalytic subunit of the GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). It is likely to convert active Rab3-GTP to the inactive form Rab3-GDP.  Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. This complex interacts with DMXL2 [1,2,3].	21.80	21.80	21.80	25.80	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.48	0.71	-4.87	27	198	2011-03-10 13:10:59	2011-03-10 13:10:59	1	5	129	0	135	196	4	158.80	43	18.68	CHANGED	sssppststthcG..thp.....hs.shhLLps.s-slatPhTQcssshTEDhlc-ctphLtphGsstp..upthptp........hQsssLlSDMpAF.................KAANPu.....shhEDFVRWa.S......P+Dal......ppt..sssp..........ps.s...............hsscGpLSpR......Mpt...pG............NhWtclWcsApshPApc.Q+.LFDstcEuEKlLHaLEs	......................................................ts......thpscGphtt....hs..phpLLcs.uEPLYlPlTQ-ss.Ph....TEDhlcEpsEllt+LGsssp..Gsthpsp........hpossLLSDMpuF..................KAANPG.....shLEDFVRWa.S......P+Dal-cp.....shsp..............pss......................................hsh+GpLStR......Mph.....u............NhW....hcsW-sAcPlPAp+.Q+pLFD-s+EAEKVLHaLt.........................	0	51	75	110
+13733	PF13891	zf-C3Hc3H		Potential DNA-binding domain	Coggill P	pcc	Jackhmmer:Q9H9L4	Domain	This domain is likely to be the DNA-binding domain of chromatin re-modelling proteins and helicases.	27.00	20.00	28.30	20.20	26.20	19.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.03	0.72	-3.91	48	422	2011-03-10 13:43:28	2011-03-10 13:43:28	1	8	116	0	277	413	0	65.20	32	16.65	CHANGED	p..C.....st....ttCpppslshscaChp..HILpDtp...QhLa+tCsh.........ts.ppCs..pPl...psttps......hCshHhp	..................t.C.....ssttCsppsLshscaChp....H..ILpDps...QshF+pCshh........tssppCspPl...csp..ppss.....hCstHh.......................	0	87	123	197
+13734	PF13892	DBINO		DNA-binding domain	Coggill P	pcc	Jackhmmer:P53115	Domain	DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-10.97	0.71	-4.14	27	402	2011-03-10 17:40:01	2011-03-10 17:40:01	1	13	236	0	268	411	1	108.90	33	8.46	CHANGED	t+phspphcplWtsls+KDlsK......spRhhsssppsphtNh+KhApLst+Es......R.+ht.........h+opKs.KDhthRA+RlhREMhsFWK+.E+-ER-hRK+sE....KEAhEptK+-EE.REA+RQpRKLNFLIoQTELYS.HFhu+Klcs...sc..h-	........................................t...............................................................................p....................t..........t......c.....p...p-h..hhK+.-+..pch+.+...t.tp....Kp.t..hEtt+ptEE....t....c...E....sc........R..Q...p.+..+LsFLlpQTELau.HFlsp+hp.....tt.......................	0	78	133	201
+13735	PF13893	RRM_5		RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Coggill P	pcc	JCSG:Target_421317_RF20609A	Domain	The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.54	0.72	-4.12	106	5485	2012-10-02 20:46:34	2011-03-18 17:52:00	1	201	405	27	3107	36633	716	56.70	21	11.51	CHANGED	l.hphhppa.G.p.l..pp.lth.hppp.........ptuhlp...a...s.shpsAppshp..th..s.ssh...h...ts..p..t.lplp...au	.........................................phhsp.a..G..p...l.........tp..l...h..l...hppp...........................sp.A.h..lp..................a........p..shps....A.pp.A.h.p............tL.......s..uph..............h.........tu....p.......lplp.h...................................	0	924	1420	2227
+13736	PF13894	zf-C2H2_4		C2H2-type zinc finger	Bateman A	agb	Jackhmmer	Domain	This family contains a number of divergent C2H2 type zinc fingers.	23.00	9.00	23.00	9.00	22.90	8.90	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.74	-7.08	0.74	-7.53	0.74	-3.23	594	26727	2012-10-03 11:22:52	2011-03-21 11:17:14	1	4325	623	12	17330	257549	774	24.50	26	7.18	CHANGED	a......tC.......sh......C......s.............p.....p..........a.......ps.....t.....p...p.lp.pHhp..p.p...c	..........................................atC..............sh...........C..............s............................p.......p.....................F..............ss...........p.............p.....p.Lp.pHhp...p.p..................................	0	4311	6366	12692
+13737	PF13895	Ig_2		Immunoglobulin domain	Bateman A	agb	Jackhmmer	Domain	This domain contains immunoglobulin-like domains.	23.80	10.00	23.80	10.00	23.70	9.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-10.50	0.72	-3.85	70	24350	2012-10-03 02:52:13	2011-03-21 11:49:24	1	2345	524	273	12457	102175	132	89.10	15	18.46	CHANGED	ps..........hlp...sss.......ss.......l..pp..Gpsl..sL.pCp....ss......s......tss..s.p....hp..hh..+.s..............................s......phl.s.......p.s.....................ps..........................a....h.........pp.............s............s...h.s..suGp.YpCps......p..st.s...........s...pt...Sssl.pl.pV	.........................................................................................................................................................h..........................h...........G..p..s..l......sL....p.Cp.....sp.................u............................p..s.......s..p...........h.p.....W...h.......+...s..................................................................................................................................................s.............p..l.s....................p.s..............................................................................pp.......................................................hh...l................ts.................................s......................................s.......h...p......c...s....G...p...Y....p.C.ps............ps...t....h......................t..........p.t..............................................................................................................................................................	0	2991	4093	7204
+13738	PF13896	Glyco_transf_49		Glycosyl-transferase for dystroglycan	Coggill P	pcc	Jackhmmer:O43505	Domain	This glycosyl-transferase brings about the glycosylation of the  alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix [1,2].	27.00	27.00	28.10	27.10	26.70	26.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-11.83	0.70	-5.33	33	771	2012-10-03 05:28:31	2011-03-21 13:31:38	1	17	123	0	493	733	5	188.60	23	52.85	CHANGED	slThsTHushcaL.csl.sls..c+Wp.GPlSlAlasPGt-hptslssIphlhpssssp....l+chsohHlhFptpc.hs...phs.....h.ps.....hph.shp.....C...sphh.sht....ph...h......t.......acs...ssphsYPlNlhRNlARpuAp.TcalhssDI-lhPSsGhlpph..hphls.p....t.p...........s.p.sppVaVlshFElpss...........s..slPpsKtELhphhpsupAh.FHpclC.pCHpsPshpcWhpts.....cs.s....thsssap...h...sh...p.p....tWEPhYIus...p...s-PhaDERhshcGp.s+hoQsathClhsYp...........FplLssAFLVH+.GIKps...tspts.pt...ch.tp...pt...pphltpchhpEhchhYs	.........................................................................................................................................................................................................................................................................................................hP.N.hRNhAh...........s.hhhh.Dh.-h.h.........shh..h.....t....................................................shhl.hFp.h............................................................................hs...s....p.t....L....h.t.........................t..............h........h.........sp...t.....W.t..........................................h................aEs.hl.............t.......................s...h.h...h..sh.......................h........hth...h..t..hp.....................h.lhs.sa.h+...sh............................................................................................................................................	0	224	269	401
+13739	PF13897	GOLD_2		Golgi-dynamics membrane-trafficking	Coggill P	pcc	Jackhmmer:Q6PL24	Domain	Sec14-like Golgi-trafficking  domain The GOLD domain is always found combined with lipid- or membrane-association domains [1].	27.00	27.00	27.50	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.77	0.71	-3.94	11	231	2012-10-03 07:10:23	2011-03-22 13:37:50	1	7	93	0	147	218	0	111.20	47	29.43	CHANGED	VGRGEllTVRVPTHscGopLFWEFATDcYDIGFGVYFEWTsssSs.....sloV+VSESoD-Ec---spp..................tsu-lEpGs.htt...s+.....PplsEIlPVYRRDsHcEVhAGSHpYPGcGVYLLKFDNSYSLWRSKTLYYRVYYT	...............Vt+G-slTlRVPTp.pG.p.hlhWEFATDpYDIGFGlaF...-Ws.ssss.....tloVplS-Ss----p....t-t.................................................tp.ppup......pp.t......t+.............sphsEllPlY...RRDsHp-V.sGSHpYPGcGlYLLKFDNSYSLhRuKolYY+VYY............................................	0	62	73	105
+13740	PF13898	DUF4205		Domain of unknown function (DUF4205)	Coggill P	pcc	Jackhmmer:A8MYZ0	Domain	The proteins in this family are uncharacterised but often named FAM188B.	21.00	21.00	21.00	21.00	20.10	20.90	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-11.93	0.70	-5.71	11	398	2011-03-22 14:02:10	2011-03-22 14:02:10	1	11	139	0	269	395	9	225.10	25	57.41	CHANGED	+plLFGoshpsFsp-W+ppsFsFs-s..tltYGLhQt+GGPCGVLAuVQAhlLKtLL..Fspss............th..tshhpssssp+ppsLstALADILWpAGc.ppcAsVsLsssc.phsss.scYptDslpEpLpLashpph--hptFlppals.Fc.pushGsILhlYSsILSRol-plppDhDsss.s....pLlGu.HG.a.CTQElVNLlLTGRAsSNVFNGs.......cpspssh.....s.L+Glts..RS-IGaLoL.....aEH..apsspVGShLKTP+hPIWVlCuE.uHYSVLFsssp-LlsDa+h....E+pF-LYYYDGLssQpctI+..LTVDspupthpss.p......t.p.....clhPPLEhsIRTKWtpAslsWNG	........................................................................h.at............ul.p..p............sG....s....p.ullssl..Quhllp.hl....h..t..............................................................p.phL.....h...sh....t....ll.....................................ht..............t........t...............h..h...................h.................t.................................................................................................................................p............t.................h..........t..h...................h......p.....h...t......p..tph..h...............h................t..h.....at..........t....Gsl.hhhhShlho+uhp..........l.p.t-hpssp....t.............Llts..hs..h..ss...tllNLhLsGpAsstlass.......................................p...th........hhGl.t..pstl.GhLth...............hpt....p...t....p..VGphhKsP.phPlWlhssp.sHhslhFs...p.....tl...t..........................................................................................................................................................................	1	88	117	187
+13741	PF13899	Thioredoxin_7		Thioredoxin-like	Coggill P	pcc	Jackhmmer:O95994	Domain	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.77	0.72	-3.96	51	3155	2012-10-03 14:45:55	2011-03-22 14:27:14	1	52	1979	19	1031	6223	2371	86.30	24	17.25	CHANGED	shhs..sh-pAl.tpApppsKslhl.hh.p..sshC.pCpsh.ccs.hhss.pplpp.lt.c.calhlphsh............sspct.ph.........thtt.......ph.......sPtlhhlss	......................t......hppul..tp..u..p..s......p..s..KP.V.hl..Dh..t..A-W...CssC+..th..c...ch..s..hsc...s......pVpp.....ht..p..s.h..lhlps-h........................sssss..p.............................htp.................hG.................hPtllhhs...........................................................	0	347	605	827
+13742	PF13900	GVQW		Putative binding domain	Coggill P	pcc	Jackhmmer:Q6ZWE1	Domain	This short domain is often found nested inside other longer domains. The function is not known, but the domain carries a highly conserved GVQW motif. The members are rich in proline and cysteine. This may be a binding domain.	28.10	28.10	28.10	28.10	27.90	28.00	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.37	0.72	-3.98	35	1257	2012-10-03 02:24:44	2011-03-23 13:28:18	1	170	16	0	72	778	423	41.40	60	18.50	CHANGED	VuQAGVQW+sLGSLQPsPPtFKpFSCLSLPSSWDYR+sPPpPAN.Fs..lF	.............ssQAGVQ...W.p.c..LuS....LQP...P.P..sFK.pFS.CLSLs...SS...WD.Y.R.....p..P.sp...s....h...................	0	55	60	61
+13743	PF13901	DUF4206		Domain of unknown function (DUF4206)	Coggill P	pcc	Jackhmmer:Q9H714	Domain	This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, Pfam:PF00169	27.70	27.70	29.40	28.90	27.50	27.60	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.74	0.71	-4.77	28	498	2011-03-23 16:23:42	2011-03-23 16:23:42	1	18	131	0	302	495	2	187.10	36	26.38	CHANGED	RhCsYsGcYaCsuCHp.s.stssIPARllcsWDFppasVSptuhphLpphhspPLlslpplNPpLYs+scpLsclpplRppLthlcpYlhsCRhus.p.tptt.........hp..t..s+pa.Lhp.s.schYSltDLlplpsG.shtth...LpplhphsppHlt.sC.LCps+GFlC...EhC......pss...clIaPFpp...t.psp+CspCtulaH+pCap...p..ss........CP+CtRhpp+c	.......................................RhCpY.GpYaCs.s.CHt.s.spslIPARll+.pWDFpch..........V..Sph..uhchLp..tlhppP.lhslp....p....lNst.LYp+...s...ctLsplpp.lR.ppL.hhh...+sa....l.......h.....o...CR......ut....p.....h.hp.........hp....ts.pa.L.h...-....s....c.......haSlpDLh.pl..p.pG..t....Lssh................LpplhphstpHlh.pCp........lCpt.+.G.F.lC...EhC.....................pss.......cllFPFp.....ps...p...Ct..pCtus...aH.p.pCht.....p...tt.........CP+C.Rhp...p........................................................................................................	0	93	124	205
+13744	PF13902	R3H-assoc		R3H-associated N-terminal domain	Coggill P	pcc	Jackhmmer:Q96D70	Domain	This family is found at the N-terminus of R3H, Pfam:PF01424, domain-containing proteins.  The function is not known.	25.00	25.00	32.60	28.10	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.75	0.71	-4.19	32	193	2011-03-23 16:27:11	2011-03-23 16:27:11	1	7	156	0	132	182	0	121.20	23	35.98	CHANGED	++phhtcculcpp-slh..u+cGsR+ppRaENc+lLpshhsp..stspp....sshshps.lP............hthsthW.ssahshst-pppphh...pthcsppcpstsptt.......................s.t.ap+ls+cLRttLK+	................................++t.hhppul+pp-slh..spcGpRpppRaENc..+hLhshhsp..ss.sps..ht.tssh.shts.sP..............hphsthW.ssah.s.tst-cpp..phh......pthpp.ptpppt.tp.tt..t...........................................ts.tthpclspchRthl++..................................................................	0	35	65	100
+13745	PF13903	Claudin_2		PMP-22/EMP/MP20/Claudin tight junction	Coggill P	pcc	Jackhmmer:A6NFC5	Family	Members of this family are claudins, that form tight junctions between cells.	31.20	31.20	31.20	31.20	31.10	31.10	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.43	0.71	-4.57	37	835	2012-10-03 00:20:40	2011-03-24 16:16:45	1	11	100	0	558	2183	0	182.30	16	73.69	CHANGED	hlAlsLllluhsTspW..lp...ss..spp..............pt..............................t.....h.t.t...hh....pp...Gh.ahhshh..................................................h.hhshshhhluh....shs.hhuslht.h.hussp...ps.t................thhhh..s.uh..h.hh.....suus.hhhhslshasthhp......h.......hpp...th..pp.....tsh....hhthGaSFhLsssushlsllsshLhLh	................................................................................................h.huhhhhhhuhs..o..s..h.W..h......hp.....th............................t................................................................................................................h............tp......Gl..a.p...h....Chh.......t.........................................................................................................................................................t..hhh.tht...hh.s...tsh.h.....hl.ul.......sl.h..lhu..h...l..hs....l..h...u..h..hp.......ps.t....................................hhhhs...s..Gh..h.hl................huG.l..hhll...ulh.ha.h.t.t..hp.......h......................h...t........tph.....................phpauWSa.h..lAhsuh.hhthlu.uhlhh.h...............................................................................	0	115	170	350
+13746	PF13904	DUF4207		Domain of unknown function (DUF4207)	Coggill P	pcc	Jackhmmer:Q96HJ3	Family	This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.45	0.70	-12.39	0.70	-5.01	19	192	2011-03-24 17:00:58	2011-03-24 17:00:58	1	4	70	0	84	188	0	234.00	25	57.05	CHANGED	s.Ss.usSspSp..hSsp.....sspsh.tspspspsps....pps..spShsshhcsh.p.............................pocsps.ssls.hphs..spsSs.....tsp.......sah+.plcth+lc+pst....pAY-sWhuuKptp.p.+.ptc.h....ttcpEcc+pc..sthRp+LAcE+YcpWh+pKspQpppp+p.p.pt......tpp........sup.....pustu...........................ss+phs....t-ps+c+lpcW.hcKhcppppcRpcpcptppp+ppccpcR+phuEtAapcWhpsVsp+PKPVPhNQGhcu..LRGTlS......slYlNPh.W	.........................................................................................................................................................................................................h...tts..u..S........t.p....sppp.pstp....p..............h..tsh..............................pspsts.s.h..hp.t............o.......pp.......s..c.p.cp.ch.cps...........tsa-sWhstKpt...pcppp.......t.h.....tpppE+cccct...tttpRppl.A.pppa..ppWhppKpcppppp+t.p.pt......pppts...psthp.....................................p+ph..t-c..sppchppW.hcKhp....ppp..pc....+...pc....pc..ptpt...p+ptp.pcR+phuptAapcWhppscp+s+Pss.hs.Ghs....LpGhhS.............hahNP..W..............................	0	17	22	47
+13747	PF13905	Thioredoxin_8		Thioredoxin-like	Coggill P	pcc	Jackhmmer:Q5VZ03	Domain	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.07	0.72	-3.87	83	2061	2012-10-03 14:45:55	2011-03-25 14:24:33	1	60	711	33	871	11398	5021	94.50	22	26.84	CHANGED	s..+hlllhFhus......hst...t..s......pp.....hhst.Lp.p...h...hpphp.......................tp....lpllhlsh............D...p.s..t.p..ph...pphhpph..............s.hh.shs.hss..t.t......pp..pl..........tpth.s..lps.................l.Pplllls.psGp.....l	..................................Khlll.Fh.us......WCs......s...C..........pt.....hhPp...Lp.c....h...hp.chp..............................tps..hpl..l..h..l..Sh......................................D........c..s....p...c......p..h..........p.p..h.h.pph.........................s...a.h...p......h.s...hss....s.t.........pp....pl...................hpta....s....l.p.u..............................l.P.s....h.llls.tpGp...........................................................	0	370	608	774
+13748	PF13906	AA_permease_C		C-terminus of AA_permease	Coggill P	pcc	Jackhmmer:Q7Z475	Domain	This is the C-terminus of AA-permease enzymes that is not captured by the models Pfam:PF00324 and Pfam:PF13520.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.63	0.72	-4.10	56	923	2012-10-03 01:44:59	2011-03-25 14:26:22	1	16	191	0	595	2651	76	50.00	44	8.37	CHANGED	FpsPhVPhlPsluIhlNlYLhhpLsshTWlRaslWhsl...GhllYhh....YGhpHS	.................FtVPhl...Ph.lPslSIh....lNlYL.MhpL.....st..tT..W...lR..Ful.....W.h...hl...Ghl.l.YFs....YGlppS..............	0	136	243	422
+13749	PF13907	DUF4208		Domain of unknown function (DUF4208)	Coggill P	pcc	Jackhmmer:Q86WR6	Domain	This domain is found at the C-terminus of chromodomain-helicase-DNA-binding proteins.  The exact function of the domain is undetermined.	23.00	23.00	23.10	23.10	22.50	21.30	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.20	0.72	-3.79	31	331	2011-03-25 14:30:37	2011-03-25 14:30:37	1	14	214	0	224	312	0	101.20	32	7.30	CHANGED	sc...s..t.tp.ptc-.h-spshsp..CKchMcPl++sL++Lc+s.sc....uLs+c.-hlphl+ppLhsIGcc....Icpplpph...pps..p.cchcc+LWhaso.pFhs..hc...upKLhphYc+h	.....................................hst....t.ptcph-.p.pshsh.CK-hh+PlKcsLKpLcps...pc..........sL.spc.-plpch+ppLlpIG-+....IsppLpph..........sss...phcpa..+cpL....WhFVS..pFot..hc........uc+LpclY++.h...................	0	52	94	163
+13750	PF13908	Shisa		Wnt and FGF inhibitory regulator	Coggill P	pcc	Jackhmmer:Q8N114	Family	Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.	27.40	27.40	27.40	27.40	27.20	27.30	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.97	0.71	-12.11	0.71	-4.10	11	427	2011-03-25 14:59:58	2011-03-25 14:59:58	1	13	55	0	239	379	0	153.30	22	54.82	CHANGED	tpGEhCh..hsshsphcPsa.CPp......p.paCCGoCuhpYCCss.h+psphsps.sCss.-p..sh.t....s.......chtpshc.sPs...pshtssllVulhhhVlhl.lshllshsC.pCsL.Kh.....................pR.ppPshopss.usshpppshsQs.st.........sph.P...usph..QsYps.sspsu.......h.ts.h.sh.hs..Ph.h.ssssssY	......................................................s...p.Ch.hahsh.utap..FpCs.............hhhC...CGsC.hRa.CCt....h....p..hp.Qt.tC.s.....................................ss..............h.lhsulh..hh.lh.h..l....hshlss.h.hs.....p.s.h.h.K.................................................pp.....p.......h..t..p...sh....sp.........h.t......t..s........t........................t..s.........p...tth.s....sst.s...............h.........................................................................................................................................................................	0	51	77	135
+13751	PF13909	zf-H2C2_5		C2H2-type zinc-finger domain	Coggill P	pcc	Jackhmmer:Q6IQ32	Domain	\N	25.00	13.60	25.00	13.60	24.90	13.50	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.10	0.73	-7.42	0.73	-3.42	73	3546	2012-10-03 11:22:52	2011-03-25 15:19:35	1	546	228	2	1708	10506	142	24.70	29	7.43	CHANGED	apCst..Cs.ats..p.tp.p.lp.pH.hphh.Hs	.........a+Cph..Cs.apo...s.pp.s.Lp.pH.hppt.H........	0	489	585	1020
+13752	PF13910	DUF4209		Domain of unknown function (DUF4209)	Coggill P	pcc	Jackhmmer:Q5T6L9	Domain	This short domain is found in bacteria and eukaryotes, though not in yeasts or Archaea. It carries a highly conserved RNxxxHG sequence motif.	22.30	22.30	22.40	22.30	21.90	21.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.34	0.72	-3.91	17	134	2011-03-25 16:11:02	2011-03-25 16:11:02	1	2	110	0	71	124	3	91.10	30	15.63	CHANGED	hl...ph.lcptlhsh.hh.shptpts...h..hLp........-lLtscplpphlspsl.............hhlL+hhlssPp..GLNLRNllaHGFls.sphp.phhshllhLhhsls	................................hph..t.h.Rtlhphhhhhsp..ps...........hhLc........-LLs..s....p.pltplhGpsl.............h.lL+lhhssPp..GLNLRNhlhHGah..ssp-lss...phsshhlhLhhtl.s...............	0	32	42	50
+13753	PF13911	AhpC-TSA_2		AhpC/TSA antioxidant enzyme	Coggill P	pcc	Jackhmmer:Q8TBF2 	Domain	This family contains proteins related to alkyl hydro-peroxide reductase (AhpC) and thiol specific antioxidant (TSA).	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.47	0.71	-10.75	0.71	-4.16	82	573	2012-10-03 14:45:55	2011-03-25 16:14:57	1	12	263	0	372	774	179	123.50	20	46.43	CHANGED	tLtpt..t..spLpt.....tG..lp..lhs....lu..hush..s...spcFt.ph.....sta..shp.la...........sDs.stphaptLsht.......................................................................................p.hh.h.th..................h.t.......h..t........th.htthtth...........th..tsh.......................................................................suthtQpGGsalhssss......pllapHc-cs	...................................................................................................s.hpt....ts..lp..lls..lu..hush......ts...hcpFt.ph........sta..s..h-..la.............sDs..p.+..phYptLGht...................................................................................................p.s...th.sh..h...sst............htps........h.p..............th..hpthpph...........s.h..ssh..................................................................................pGshhQtGGhhlh........stss.....plhataht............................................................	0	127	219	297
+13754	PF13912	zf-C2H2_6		C2H2-type zinc finger	Coggill P	pcc	Jackhmmer:C9JL96	Domain	\N	25.00	5.00	25.00	7.50	24.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.09	0.72	-7.35	0.72	-3.91	81	8615	2012-10-03 11:22:52	2011-03-25 16:26:12	1	2303	333	9	4881	167936	200	24.80	27	6.24	CHANGED	hapCshCpppF..sshpslhsHK.ppa.ppt	...........apCs.t..C.s...cs.F......ssh.p.s...L..h.tHh..p.h....t..................	0	845	1687	3070
+13755	PF13913	zf-C2HC_2		zinc-finger of a C2HC-type	Coggill P	pcc	Jackhmmer:Q5TFG8	Domain	This family contains a number of divergent C2H2 type zinc fingers.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.93	0.72	-7.00	0.72	-4.21	111	1078	2012-10-03 11:22:52	2011-03-25 17:14:21	1	55	127	0	709	1684	18	24.70	37	10.97	CHANGED	phh.C.thCGRpF.sscplt+H....tphCp	......hh.C..hCGRpF.ss.s.s.l.ppH........shCp..........	0	305	367	517
+13756	PF13914	Phostensin		Phostensin PP1-binding and SH3-binding region	Coggill P	pcc	Jackhmmer:Q4KMQ1	Domain	Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton [1]. Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [2].	25.00	25.00	25.10	25.10	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.63	0.71	-4.04	5	99	2011-03-28 10:56:36	2011-03-28 11:56:36	1	5	42	0	53	90	0	122.60	49	22.28	CHANGED	APQtAK.Psssh...Pup.pLHPA+PGcsutL.pRGuNTFTVVPKRKPGoL...thSQANsposspsAE---AsuL.......Gs......TLKKRYPTVHEIEVIGGYLALpKSCLoKAGSSR..KKMKISFNDKuLpTTFEYPSESSLlQ	.....................................sp.sh...sh.....sh..hass+sG.ssth....pR...uGpTFTVsP+Rpss.............Asst...s.sp.........Ap.t..-sAs.................ss........shKKRYPTscEI.VlGGYLpLp+SCL.sKu..uspR..KphKISFsEsuLpTTapYPSESSllp...	1	6	12	23
+13757	PF13915	DUF4210		Domain of unknown function (DUF4210)	Coggill P	pcc	Jackhmmer:Q32MH5	Domain	This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.	21.20	21.20	24.10	22.70	20.10	19.30	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.25	0.72	-3.68	21	277	2011-03-28 12:49:58	2011-03-28 13:49:58	1	5	173	0	185	275	0	63.10	49	7.99	CHANGED	LlGSFEESlLpGRhs..P.op.l-GFhAplGloGut......asPtplplPFsshaap.......hu..ssss.....sPYl	..LlGsFE..ESlLpGRhs..P.st.l-GFsAp....lGsoGs...............aCPsHlTLPhsssFYs........sS..-suP.........oPYh....................	0	41	78	126
+13758	PF13916	Phostensin_N		PP1-regulatory protein, Phostensin N-terminal	Coggill P	pcc	Jackhmmer:Q4KMQ1	Domain	Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton [1].  Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends [2].	23.00	23.00	24.40	23.50	22.20	21.10	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.81	0.72	-4.00	4	58	2011-03-28 12:54:51	2011-03-28 13:54:51	1	4	30	0	30	50	0	83.50	56	14.78	CHANGED	s-ps.hotMPAWKRtILERRRAKLuh.sGt..suP.......GsA-.....PsEptVLhEulGPl+QN.Fhp.EppRpptpptttpcLLtch+tsP	..................AER-RLSQMPAWKRGlLERRRAKLGL....uP.....GE..P.uPh.s...................s-uGss-...........PDESuVLLEAIGPVHQNRFIRQERpppp....pp...p......Qp...p.....p-LLt.chpss........................	0	2	8	13
+13759	PF13917	zf-CCHC_3		Zinc knuckle	Coggill P	pcc	Jackhmmer:Q8TBK6	Domain	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag  proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.	27.00	10.00	27.00	10.00	26.90	9.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.62	0.72	-8.34	0.72	-4.22	25	384	2012-10-03 11:39:54	2011-03-29 14:02:14	1	40	191	0	234	1569	12	40.60	31	17.55	CHANGED	ssusspCQKCLphGHW...TYECK..........sc+....sYs.......sRPSRTQpLcps.l	........s...pstCpKCh....phG.........Hh..........TaEC+....................tpp...................................................................................	0	90	133	193
+13760	PF13918	PLDc_3		PLD-like domain	Coggill P	pcc	Jackhmmer:Q8N7P1	Domain	\N	27.00	27.00	27.50	27.00	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.12	0.71	-4.84	5	475	2012-10-02 13:01:53	2011-03-29 14:42:38	1	7	150	0	155	456	3	169.10	38	45.75	CHANGED	SluTIKNLGLYSTN.K+LAhDLMNRYNTFSSMls-PKlPFT...RhCCuM.lTPTATsFHLNHoGGGlFFSDSPERFLGFYRTLDEDLVLHRI-uAKNSIDLSLLShVPVlR+uosVcYWPcIhDALLRAAI-RuVRVRlIIopWKNADPLSVAAARSLc-FG..VGslDlSVRhFulPGR	........................................................SloplKpLGlh..hN.spLAhDLtphFpsaasht..s...p..s..p..l.P.o....h.....phsssh..spsss.hph..p.l..s.p............s.s..u.s......lF.....hS.s..SP.pthh..sh.tRThDhDslL.phIcsA+p.I.lulhshlP....lh....c...h.s....s.s......h...p.YW.PtI.suLhcA.A.lpR.uV+VRlLlo.pWc..psDPhth.s.hl+SLp...sh.s........ss...s..ss..lpV..+hFslP.............................	0	40	55	103
+13761	PF13919	ASXH	Asx-hm;	Asx homology domain	Iyer LM, Aravind L, Godzik A, Coggill P	pcc	Manual	Domain	A conserved alpha helical domain with a characteristic LXXLL motif [1] [2]. The LXXLL motif is detected in diverse transcription  factors, coactivators and corepressors and is implicated in mediating interactions between them [3]. The ASXH domain is found in animals, fungi and plants [4] and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade  of DUBs [4].	25.80	25.80	25.80	27.20	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.73	0.71	-4.38	85	311	2012-10-09 14:14:56	2011-03-29 16:45:12	1	10	155	0	174	299	0	133.90	41	12.83	CHANGED	ptps..++hssu.....Qh+ps+.st.cl..DlEoPcSILlsTNL.RuLlN.pcTF.ssLPtphQppLltLLPc.........VDRpsu......................................ssshl+.LssS.sLN.NEFFscAsppW+-RLu-GEFTPEhQ......................h+l+pEtE+E+.KlDsWKE+aFEsaWGpK	...........................................ht.....cp.ttt..phKps+...st...cl...DlE...oPsSIL.l......sT..NL.RA...Ll.N.pcTF.ssLPschQppLLhLLP-.............VDRpsu.........................................s-uhl+..L...ssS..sLN...NEFFspAspsW+-RLu.-..GEF...TPEhQ...............................l+l+..pEhE+EK.......Kh-.WKE+aFEsaaGp.....................................	0	37	66	112
+13762	PF13920	zf-C3HC4_3		Zinc finger, C3HC4 type (RING finger)	Coggill P	pcc	Jackhmmer:Q9BY78	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.78	0.72	-4.29	585	5985	2012-10-03 15:03:13	2011-03-29 16:58:25	1	423	488	23	3675	15063	738	49.20	31	9.50	CHANGED	ppph....Chl.......Ch.s......p.......p..t...s........s.lhh..P....C..s..HhshCtpCuppl......................ppCPl..CRp.slp..ph	.............................p..ttChl.Ch...c.......................p....................t....s........................s..l.h.h.....P........C..u...Hh..hC...ppCupph..................................................ppCPl..CRp.lp..h...........................	0	1260	1981	2858
+13763	PF13921	Myb_DNA-bind_6		Myb-like DNA-binding domain	Coggill P	pcc	Jackhmmer:Q15361	Domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.04	0.72	-3.86	39	4769	2012-10-04 14:01:12	2011-03-30 11:08:35	1	107	621	51	3074	13999	171	61.90	27	16.83	CHANGED	WTp-E-chL....hphhpp........h....u..t........s...WppI.....upt..l.s...........Ros..tpltpRap..p...L..........p.........s.p.......hppss..asc.p-pppL	............................................................WTp.-ED.phL..........hphl...pp...................................a............G...p........................p.....Wsp.I.............upt....l..s.................................Ros..ppC.c.p....R.Wp....p......hL......................p.............s.p.....................hp.p..t.......as..t-.......................................................................................	0	1464	2097	2635
+13764	PF13922	PHD_3		PHD domain of transcriptional enhancer, Asx	Coggill P	pcc	Jackhmmer:Q76L83	Domain	This is the DNA-binding domain on the additional sex combs-like 1 proteins. The Asx protein acts as an enhancer of trithorax and polycomb in displaying bidirectional homoeotic phenotypes in Drosophila, suggesting that it is required for maintenance of both activation and silencing of Hox genes. Asx is required for normal adult haematopoiesis and its function depends on its cellular context.	25.00	25.00	36.40	34.50	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.03	0.72	-3.73	13	166	2011-03-30 10:10:42	2011-03-30 11:10:42	1	4	63	0	89	168	0	65.00	59	4.50	CHANGED	ppt.....tpsps....pstp..h..Qp....ospNT.........................s...pussspCuCuLpAMVlCQpCGAFCHDDCIGsSKLCVSClI	................................................t..s......uupsts..lslQhFs-pss.........................sEshs.KCsCRLK.AMIMC+GC..GAFCHDDCIGPSKLCVuCLV...	0	12	18	41
+13765	PF13923	zf-C3HC4_2		Zinc finger, C3HC4 type (RING finger)	Coggill P	pcc	Jackhmmer:Q5VTB9	Domain	\N	27.00	20.00	27.00	20.00	26.90	19.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-9.23	0.72	-3.92	345	3897	2012-10-03 15:03:13	2011-03-30 11:46:46	1	230	817	11	2262	19172	876	41.60	35	7.80	CHANGED	CslC.hp.ph.ps.....s.h..hh.s..C..u..H..h.h.C.p.pC...ht..p..h..hpp.t..........p..p....C..Ph..C	...................CslC...hc..hh...pc.................P.h....hs..s....C......G........H....h.F.C.p..pC........lt...c....h..hps..p..............................p...........C..Ph..C..................................	0	782	1217	1747
+13766	PF13924	Lipocalin_5		Lipocalin-like domain	Bateman A	agb	Jackhmmer:C7PBJ6	Domain	This family includes domains distantly related to lipocalins. However, they do contain the important GXW motif in the first strand. The protein in this family include aln5 Swiss:B6SEG2 which is involved in biosynthesis of alnumycin [1]. The family also includes the ZFK protein from Trypanosoma brucei which is a protein kinase. This domain is at the C-terminus of that protein [2]. The domain is also found as the C-terminal domain in StiJ a protein involved in producing stigmatellin. This domain has been assumed to catalyse a final cyclisation reaction [3].	21.10	21.10	21.60	21.90	20.80	20.80	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.80	0.71	-4.49	68	249	2012-10-03 08:47:39	2011-03-30 13:10:08	1	8	197	0	95	228	57	132.90	25	64.70	CHANGED	hG.sWcLlu...hphpss-Gs...................................hhhPhGp.sPpGhlhYsscGhh.osplhptsR......................h.sss.hpuosp-hsp..shpshluYsGpY.....plcss.........plhacl-suhhPsWl..GspQpRphplc.s.....cp...Lhlt...tstshhhsst.tt.....shLsWcRh	..................................................hGsWpLlS...hph...ss.s...................................hhhPhGp...ss...hGhlhYstpG.hhuspl.hsss...Rst....................hsstshhtss..sp.-h....st..shpshluYsGcY.........plccs..........................thlsHpl-suh.hPNWl..Gs.pQpR...h.aphc.t.........-p...LpLt....phssh.hsst.hh.....shLhWp+................................................	0	26	56	76
+13767	PF13925	Katanin_con80		con80 domain of Katanin	Coggill P	pcc	Jackhmmer:Q9P0V8	Domain	The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles [1].  The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein [2].	27.00	27.00	27.20	27.40	26.70	26.60	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.66	0.71	-4.51	33	279	2011-04-01 14:39:33	2011-04-01 15:39:33	1	12	127	0	176	262	0	145.60	30	26.00	CHANGED	pcsHsshhpsLpsRhppLpslcphW.ppssl+sulsshtph...pDhulLsDlLsllp..t+ppt.....hsL-hCstlLPhlppLLp.S+aEpalpsuLchLptllppFtshIpsshp..ssstsulDlstEpRh...p+sptshppLpplpphlpths.p...psGplGppupcLphhls	...................................psH-shhpsLpuRhtpL.....psshphW.pppslps...slshhhph.........pDhuVl.sDlLslls.......ptph......hsL-hCsslL....Phlp.pLLp.S+a.EpaltsuhshLphllppFhshl.....pst...ht....s.spluVDlptE-.Rh...............ppsphshppLppl.ph..tht.....h.G.hup..hpclp.hh.....................	0	52	80	127
+13768	PF13926	DUF4211		Domain of unknown function (DUF4211)	Coggill P	pcc	Jackhmmer:Q8N4S0	Family	\N	27.00	27.00	28.00	28.00	22.30	21.40	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.58	0.71	-4.81	38	274	2011-04-01 15:59:20	2011-04-01 16:59:20	1	7	160	0	173	252	0	146.50	23	14.76	CHANGED	c-Flhp-p................t.s...sstsphshphshpsppsh+-pFcshlchhVpstLcssFhpsh.....t.....chahsuhc+l-sp.lpsppcslltsosWsssapcuLcshPplplhth.........psttCpACpcss+ss.shcl+hsGcsY...........spcT......Lpshppsss	.....................................................................................t.....pt..................t.tss....tt.tpsphshttp.h.hspp..sh+-pFcshlchLlppALDPs.hhpsl.c.ppp........chaLssh++lDsh.lpspp...cplltps.thspp...appuLcsaPpl.h........................t.hsCpuCsps.st...shcl+hsGcsY...........NpcT......Lp..ph...s..................................................	0	40	64	114
+13769	PF13927	Ig_3		Immunoglobulin domain	Coggill P	pcc	Jackhmmer:O60384	Domain	This family contains immunoglobulin-like domains.	27.00	15.30	27.00	15.30	26.90	15.20	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.84	0.72	-3.46	182	4712	2012-10-03 02:52:13	2011-04-04 12:51:01	1	772	224	45	2131	57861	94	77.20	17	13.25	CHANGED	pPplthp.sts.t...............lsLp...Cpstss..........ssphpWh............................tstttttsspsslsls.........hp.....ppsss..asC....hs...ps	.............................................................................................................P.l.h..t.....hts.................lsLp..........C...pupss..............................ssphtWh.......................................................................................t..s...p...t....t....t...s...t......s....p...u....s...ls.ls...................................ssp........................pcsGs.....YpC..hu.p...............................................................................................................	0	498	693	1156
+13770	PF13928	Flocculin_t3		Flocculin type 3 repeat	Bateman A	agb	Jackhmmer:Q5AF39	Repeat	This repeat is found in the Flocculation protein FLO9 Swiss:P39712 close to its C-terminus.	21.90	21.90	22.20	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.03	0.72	-8.62	0.72	-3.80	149	538	2011-04-06 11:49:32	2011-04-06 12:49:32	1	38	52	0	311	544	0	43.50	44	15.50	CHANGED	sTTllTlTSCs.c........spCspos...........l......oTu.so....sls.........ssp..TsYTT..YCPLo	....................pTTllTlTSCp.s........shCopos................V.......oTu..ss....TVs.........sss..ThYTT..aCPlo..................	0	57	149	285
+13771	PF13929	mRNA_stabil		mRNA stabilisation	Eberhardt R	re3	Jackhmmer:Q03153	Family	This domain is an mRNA stabilisation factor [1].	25.00	25.00	57.90	27.50	20.70	20.70	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.86	0.70	-5.46	7	26	2011-04-06 12:28:04	2011-04-06 13:28:04	1	2	24	0	15	23	0	267.70	34	48.31	CHANGED	hplhpsLsppD....actuppllsssp..p.p.l+sltsslppL.pph....clsscpWhphh-pphPhlh.pps...aWssRhpaapLL.hss.pph................slp...phh.-YLhhKpuhGtplsccDLlsFLplh.pplpsspp....Y.pLVppNphllcALpLac..psc....llhDspllshLLpoMss.ppp....pL+uhYEhlcals..ppat.pths.ssltpllpsLschpsWscLhpFWctthss.s.tpDpRPWs.Fl+slspsGDpplh+cllccGpLLWIpRspVs..hos-LpstLpcLFppus	...................s..hh.hLpppD....Fctuscll.pss..st.sphc..l+olpcshssLpp.s..tpclcsspWpphFDpp.shlshspst......YWslRhcahhLLNcscPphY....................os+...halpDYLlLK+ShGpcLh+-DLluhLchllps.css+p....YhsLVcpNchllcALpLact.psc...tpllhDppVlohLLpoMlsp-cs....+LcuLYEsI-alh...poas.ccLTsshIlsILpsLAch+-WsKLhphW-shsss.s.sp.......DpRPWscFIpllspoGDsplhpKllssGHLLWI+RhsVs..l..oscLpsslctLhcpss......	0	3	8	14
+13772	PF13930	Endonuclea_NS_2		DNA/RNA non-specific endonuclease	Coggill P, Punta M	mp13	Jackhmmer:D0LUR7	Domain	\N	27.00	27.00	27.10	27.00	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.79	0.71	-4.12	50	1121	2012-10-05 18:28:12	2011-04-06 14:28:53	1	34	776	3	170	1036	12	132.40	26	35.41	CHANGED	PNspYps....sGh....hY.pTDphGRlspspu..pLp..L.h.t..p......scR.NsapQsss..Gp..........s...th.t....Dc.GGHLIustFsGssc.h.cNLVshspp.lNc......GpahphEpcWAs..ulpps..+pV.plcIpPlYpGs.S..RPssFplp.YpIss	...............................................................................t.................hh..phDphsRhttsps.....ht......h........p.................ttR...t.s.h......t...pss......uhh.t......................t.....tp.......tt.h..................h....s....RuH..LI......u........hp..h...............u...............G........p..............ss.....p..c.....NLsstoph.lNp...................sshhh....aE....sp....lpp...........shcps.....ppV...pYcls.PlYp.Gs..p...Lhspthplp.h.....................................	0	44	92	135
+13773	PF13931	Microtub_bind		Kinesin-associated microtubule-binding	Eberhardt R	re3	Jackhmmer:P46863	Family	This domain binds to micotubules [1,2].	25.00	25.00	25.60	25.60	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.08	0.71	-4.04	11	156	2011-04-08 14:37:49	2011-04-08 15:37:49	1	3	133	0	105	156	0	99.50	31	9.52	CHANGED	-LKh.hPTGTTPpR+casYP+sLstTpP+-pIlcRa+pEQshsp.hshsssIsEhscE-ss....pslpulpt.clpsoEslhsspsh.-hs-ssppttth..hQ.ppstsKttpsps.ps.lcp.psp.sppppu..........ls+ShhP.+tss	.....Lpp.hPTG.sTPp++pYtYPssLsRTcPH-pLlp.ph+...ppp.....................................................................................................................................................................................................................................................	0	23	39	72
+13774	PF13932	GIDA_assoc_3		GidA associated domain 3	Punta M	mp13	Jackhmmer:D0LLL5	Domain	The GidA associated domain 3 is a motif that has been identified at the C-terminus of protein GidA. It consists of 4 helices, the last three being rather short and forming small bundle at the top end of the first longer one. It is here named helical domain 3 because in GidA it is preceded by two other C-terminal helical domain (based on crystal structures [1,2]). GidA is an tRNA modification enzyme found in bacteria and mitochondrial. Based on mutational analysis this domain has been suggested to be implicated in binding of the D-stem of tRNA [2] and to be responsible for the interaction with protein MnmE [1]. Structures of GidA in complex with either tRNA or MnmE are missing. Reported to bind to Pfam family MnmE, Pfam:PF12631.	27.00	27.00	30.60	29.20	26.20	24.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.87	0.72	-9.16	0.72	-3.92	60	4262	2011-04-08 14:57:33	2011-04-08 15:57:33	1	15	4143	17	1037	3177	2191	71.90	46	11.44	CHANGED	lKYpGYIcRQpppl.c+hc+hEshplPpclDYsplpuLSpEu+cKLscl+PpTlGQAuRIsGVoPADIolLll	...............lKYpGYIp+Qpppl.-+hc.+hEspplPtslD..Y..s..p..l..s..G..L..SsEsppKLpch+PtoIGQASRISGVoPAsISlLll...................	0	354	654	866
+13775	PF13933	HRXXH		Putative peptidase family	Bateman A	agb	Jackhmmer:Q5A0Y5	Domain	This family of putative peptidases are closely related to the M35 family Pfam:PF02102. In this family the metal binding HEXXH motif is replaced with HRXXH. The exact function of these proteins is unknown. Members of this family are found to be fungal allergens.	21.40	21.40	21.40	21.40	21.30	21.10	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.70	0.70	-4.96	28	85	2012-10-03 04:41:15	2011-04-08 16:09:36	1	3	72	0	60	112	0	225.10	40	80.13	CHANGED	hhlllhsusshAussss.............tspsssssssshsWsuuh.....................sssFP.IHpSCNuTppcQLpsGLpEshpLAsHA+-HlLRaGspSpha+KYFGs.........usou-slGha-pll...........................suDKushLFRCDDPDGNCs..ss.WAGHWRGpNATsETVICDLSYp..oR+.LsplCutGYTVusussNsaWAsDLLHRlaHlPslG.pGhl-Ha....A-sY--VLcLAcs.NuohAlRsS-oLpYFAlDVYAaDlAlPGhGCsGc	.................................................h.hhh..............................t....ts..shshpt.sh.....................htsaP.IHpSC.Ns.T.ppp..LptuLp-shplAt+A+-Hl.......LcaG.scSth.a++YFGs.........usshpsl..G.ha-pls...........................susK....u.shLFRCDDs...Ds..sC......t.pss...aAGH.WRGpNAo.sETV..IC-lSYp..oR+sLsslCs.....tGaTVu.s.utss.paa..usDLL....HRhhHlP....slu..cuhVcHa....A-..sYp-llcLAps.Nsohus+socsLpYaAhDVYuaDlulPG.GCsGc...............................................................	0	13	30	53
+13776	PF13934	ELYS		Nuclear pore complex assembly	Wood V, Coggill P	pcc	Jackhmmer:O94384	Family	ELYS (embryonic large molecule derived from yolk sac) is conserved from fungi such Aspergillus nidulans and Schizosaccharomyces pombe to human [1]. It is important for the assembly of the nuclear pore complex [2].	27.00	27.00	27.30	27.00	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.63	0.70	-4.62	41	211	2011-04-11 16:17:10	2011-04-11 17:17:10	1	6	177	0	151	221	1	232.90	25	21.47	CHANGED	spLalDcLLpt....h....ul..............................ps.spthYPPco...L+s.Lhchllssss.....st..p..pKpullhYlLhDh.....cpt..............................phsppFupphtlscphhhhlcuhWhLD+...h-...acpAlchL..scP....ulh.....ssassc....IlpsLhp...............p.tsss...lAhtahpsssPslsos.............pslphhhsh.LspsslsEAFtatRphss...cpt...................p.hhEpllpaslp.t....................p.s.pp.h..hc.LlsLPhsppEEphlpc.h.......Lc...psspp....h.......sc-sllh	.......................................................................hLhlDtllpt....l.....sl.......................................ps.stthYPPpo...L+s.Lhphhh.....s.sh.......................sp....t.....tKpul...hhYlLhDh.......pts...............................p.hppFspshsls.phhhhhpGhWhLD+................t-.........................appAlchL.....scP.....uhh.........sphtsc....IlpsLhp........................p.tctp...hALtYhps..spPslsos...................................pslphhhsh...Ltp....s...slsEAahatRptss....ph.......................hcpLlphhhptpt.....................c.ttt.hpcLlpLPasspE-chlpc.hLp....sssth........spphlhh............................................	0	41	75	118
+13777	PF13935	Ead_Ea22		Ead/Ea22-like protein	Bateman A	agb	Jackhmmer:B2PIW3	Family	This family contains phage proteins and bacterial proteins that are likely to represent integrated phage proteins. This family includes the Lambda phage Ea22 early protein as well as the Bacteriophage P22 Ead protein.	27.00	27.00	27.10	27.50	26.10	26.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-11.18	0.71	-3.85	41	775	2011-04-12 10:52:06	2011-04-12 11:52:06	1	2	384	0	12	500	1	137.90	35	66.99	CHANGED	SpIsp..QALRE......sAcpAttu..h.......h.hh.t.t.t...h............................t...........................pspalst...h...s....PpslLALLDEhEp.......tpphlcthc.........s.cls.shsphpp.....cLcstcph...........................................................................................t.t..hp..hst.t.......RlA-L.E	............................................................ScIsY..QALRE......sAEp...Ahpupah.......h.hh.sppt.h...............................thhcp.hpth........................ssspFlshs...s....PssVLALLDEpE+................................sQphIcch-pc..............Np-lALs...lsKLRs.......-LEsscpph............................................................................................p.t....t................................................................................................................................................................	0	1	1	5
+13778	PF13936	HTH_38		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:B2PKW2	Domain	This helix-turn-helix domain is often found in transferases and is likely to be DNA-binding.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.94	0.72	-4.40	170	4579	2012-10-04 14:01:12	2011-04-12 12:55:48	1	55	1701	4	685	4174	318	42.50	36	15.56	CHANGED	phppLohpERtp....Ip.th...h.p...pG.hShp...p.IAcpLs+ssSTIuREl+Rs	......................ppLThpp.Rhp...........Ip..th............h.p.......pG.hS.R...p.IActLG+u.sTIpREl+Rs........	0	188	368	496
+13779	PF13937	DUF4212		Domain of unknown function (DUF4212)	Punta M	mp13	Jackhammer:D0LH74	Family	This family includes several putative integral membrane proteins.	30.00	30.00	33.60	32.20	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.21	0.72	-9.63	0.72	-3.98	71	560	2011-04-12 12:23:16	2011-04-12 13:23:16	1	4	541	0	211	473	1169	80.10	43	74.54	CHANGED	pptptYW+pNl+LlhhLLsIWFlVSFG..hsll..hscsLsplp..l..hGasLGFWhApQGuIhlFllLIahYuhtMs+LD+caslcE	........c.ttpsYW+pNlp.llhsLLslWFl.VSFG...suIL...h........s........cs.......L......sp.lp...h......uGa.sLGFWFAQQGSIhsFlsLIFlYshpMsp.LD+caslpc.................	0	53	136	183
+13780	PF13938	DUF4213		Domain of unknown function (DUF4213)	Eberhardt R	re3	COG2014	Family	This domain of unknown function has an enolase N-terminal domain-like fold. Its genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. This domain is often found at the N-terminus of proteins containing DUF364, Pfam:PF04016.	23.50	23.50	23.80	27.90	22.60	23.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.83	0.72	-3.85	59	215	2011-04-12 12:28:01	2011-04-12 13:28:01	1	4	184	6	124	217	9	86.60	23	32.70	CHANGED	lh-tlhpt....hp.shplcclslGlt..aTsVphspt.thGlA..hT.hpsh............h..h.hsup..ltGpsspclhphhh..uhs.slcpulGlAslNAlhp	....................hctlhpt....hp..shplpchshGht..aohVpss..s..t...uhGlu..hThhppt.................th....h.hssp..lt.Gpslc..clsphht..Shs..lctolGlAslNAl.....	0	51	88	108
+13781	PF13939	TisB_toxin		Toxin TisB, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:A5A627	Family	TisB (toxicity-induced by SOS B) is an SOS-induced toxic peptide. It is a hydrophobic membrane-spanning protein which inhibits cell growth [1]. Its expression is inhibited by the antisense RNA IstR-1, which acts as an antitoxin [2].	27.00	27.00	55.50	55.40	14.00	13.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.61	0.72	-7.09	0.72	-4.19	2	56	2011-04-12 12:59:00	2011-04-12 13:59:00	1	1	56	0	3	12	0	28.00	89	94.00	CHANGED	MushDIhILILKLhVAsLQLLDAVLK.h	MSLVDIsILILKLIVAALQLLDAVLKYL.	0	1	1	3
+13782	PF13940	Ldr_toxin		Toxin Ldr, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:E8XFD8	Family	This family includes the Ldr (long direct repeat) toxins. In Escherichia coli there are four Ldr toxins, LdrA, LdrB, LdrC and LdrD. These toxins inhibit cell growth, decrease cell viability and cause nucleoid condensation. LdrD expression is inhibited by the antisense RNA RdlD, which functions as an antitoxin [1].	27.00	27.00	39.60	39.30	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.68	0.72	-4.18	5	958	2011-04-12 13:02:29	2011-04-12 14:02:29	1	1	369	0	11	214	1	34.90	74	70.82	CHANGED	MTLsQLGlAFWHDLAAPlIAGIIAulIVNWLRcRK	..MTLApLuMsFWHDLAAPllAGIlsuhIVsWhppRK....	0	3	3	5
+13783	PF13941	MutL		MutL protein	Bateman A	agb	Jackhmmer:B2PG71	Family	This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family [2].	27.00	27.00	27.00	29.30	26.90	25.60	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.20	0.70	-6.16	38	371	2012-10-02 23:34:14	2011-04-12 14:12:58	1	3	341	0	69	264	97	432.00	39	94.36	CHANGED	slLssDlGSThT+sshh-...ssphcllupupuPTTV..t.tDVshGlppAlpclpcph....................shts..hshsphhuoSSAAGGL+MslhGLV.chTscAA+cAALuAGAplhpshuh.................clscpclcclpplpPDlILLuGGsDGGspcsllpNAchlu.ph........shshP......lIYAGNpsspcclpcILt..tsptslhls-NVhPcl-plNlpPsRcsIpclFhc+Ih.cA.Ghsc.lpchs......stslhPTPuAVhpsschluc.......thGsllslDlGGATTDlaSls....cst.t..thhhp...-PhsKRTVEGDLGhthustsllcthu...ttlhchhs.....tth.ptlpphhtpsshlPp.sc-Ethh-ptLAptAlphAlcRHsGphpplhsshtphh..ht.G+DLs........plchllGoGGsLs+usp..spplLpthhps.tt....lhPspp.....sclhlDppYlhuuhGlLup.htP-sAhplhccslth	...................................................................p.hlsl-IGSThTKsshFp...ss..thp...........hlupuhsPTTl..t...tclthGhpsAlspltpts...................s........shsphhssSSAuGGL+hsshGLs.shTscAA+cAAhuAGAplttshuh...................................pls.cpDlpp.l.p.cspP-IlLl..sGGsD.s...G-cchslpNA.+hlA.pu...............pL.s.ss...............llYAGNpclpccVpcIhs.....t.tpslshl-NVhPclDhlsltss.RpsIp-lF.c+Is.pu.Ghcs.l.h-hs......s..cplhPTPtAVhpsschlup.......uhs-hlllDlGGATTDVaSss...........tusst.sshllc....PEPhsKRTVEGDLGhhVsAhslsctssc......h....ht.................t.hcchhtp.chlPt..spcEt.hhsphLAt.sVthAspRHAGshpplhTssGps........lthG+DLo........sV+hVlGoGGhLo+sst...htclL+hhph..ssssp.....lL.ssc...................sphhlDpcYlhuulGslAp.s.PptAh+hhtphh..h.......................................................................................................	1	39	56	65
+13784	PF13942	Lipoprotein_20		YfhG lipoprotein	Bateman A	agb	Jackhmmer:B2PEB8	Family	This family includes the YfhG protein from E. coli Swiss:P0AD44. Members of this family have an N-terminal lipoprotein attachment site. The members of this family are functionally uncharacterized.	27.00	27.00	56.70	30.30	25.20	21.80	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-11.06	0.71	-4.74	26	543	2011-04-12 15:31:32	2011-04-12 16:31:32	1	2	534	0	41	227	3	177.70	71	74.12	CHANGED	lPcpplsDYRhssCcslWslpstsu.sNsLYWLRshDCA-RLssspARspA+pls...sssWpsuF+puILLssAchTssERRphlspLssaShphPsslRPLhQLWR-pQsLplsLuEERtRYp+LQpsoDucLDpLRppps+LptpLpsToRKLENLTDIERQLSoRKpst....sphs-sscss	.....l.PhYQLADYLoTcCuDIWuLpGKuTETNPLYWLRAMDCADRLMPAQSRpQARpas...DsoWQNsFKQGILLADAKITPhERRQlVuRl-ALSspIPAQVRPLYQLWRDGQALQLQLAEERQRYSKLQQoSDSELDTLRQQppsLQpQLELTTRKLENLTDIERQLSTRKPAGNasPDTPHps...........	0	1	9	24
+13785	PF13943	WPP		WPP domain	Woodcraft BJ	agb	Woodcraft BJ	Domain	\N	20.10	20.10	22.40	24.20	18.60	17.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.24	0.72	-3.80	25	109	2011-04-14 10:02:01	2011-04-14 11:02:01	1	14	29	0	65	111	2	95.70	43	27.43	CHANGED	Sl+lWPPoQpTRchlVcRhscsLoo..sSIlS++..YGsLsc-EApcsA+pIE-tAFusAsp.....thssps-sDGhpslQlYuKEsSKhMLEslKptspspssspss	..............ShplWPPoppTRphlVcRhspsLos..sSlho++..YGslsppEAccsA+tIE-tAFusAsp......thpt..psssDGhpslQlYuKEsS+hhLEhlKptststtt...ss................................	2	10	39	50
+13786	PF13944	Lipocalin_6		Lipocalin-like domain	Coggill P	pcc	Jackhmmer:JCSG_Target393211_GS13544C	Domain	\N	27.00	27.00	27.40	27.10	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.86	0.71	-4.00	21	111	2012-10-03 08:47:39	2011-04-14 14:22:19	1	6	70	1	13	99	0	127.70	22	39.62	CHANGED	clAGsYpGshslolss...sssshsos....ps...pplpIspss-sTlplplsshs.hth...G..lslGchsVsssslcpsssuhhp.hs.ssshp........scspss...............shss.olsGTl.psGshslshshc....s.Gu...hshslpssas	.............plsGsYpGshs.lslss....ssssht.s....hspplplsp.sscss...lplpLpsFsh........G...hplG-lsls.slsVppssss....thh..hs.tpshp.......hpspss...............shss.olsG..Tl..psuphshsls...lp.....sss.......hshslpssa.....................................................................................	0	7	10	13
+13787	PF13945	NST1		Salt tolerance down-regulator	Wood V, Coggill P	pcc	Jackhmmer:Q09863	Family	NST1 is a family of proteins that seem to be involved, directly or indirectly, in the salt sensitivity of some cellular functions in yeast. It does this without affecting sodium accumulation. It negatively affects salt-tolerance through an interaction with the splicing factor Msl1p. This interaction stresses the importance of efficient RNA processing under salt stress conditions [1].	20.00	20.00	20.60	21.70	19.70	19.30	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.67	0.71	-11.31	0.71	-4.22	7	142	2011-04-14 14:53:59	2011-04-14 15:53:59	1	5	122	0	112	155	0	154.10	34	13.95	CHANGED	hDDpsp..hpspupp.ppphs...ts.hps.ssoKpKKKKKK+p+.upusShpssspps...s.STsps....ts..sLs...........psuh+.hpccc.IWsTSopEEREpI+EFWLpLuE-ERRSLVKVEKEAVL+KMKEQQKHSCSCoVCGRKRsAIEEELEVLYDAYYEELEQYANh.Qsshpsusslssssp	......................................................................spt........................................tttptppt.c...........t.....tt......t......t.....s..t.t............................t............................s..s.........................ps.t...hsppp..IW.s..oSop.E.....ERE......pI+cFWLsLuE-ER+sLVKlEK-uVL+KM.KE......Q....Q..+...............H...........o...........CSCoVCGRK.Rs.....AIEEELEsLYDuYY-.ELE.paApt.................t.................	0	35	64	99
+13788	PF13946	DUF4214		Domain of unknown function (DUF4214)	Coggill P	pcc	Pfam-B_781 (release 24.0)	Domain	This domain is found on a variety of different proteins including transferases, and allergen V5/Tpx-1 related proteins.	23.00	23.00	23.00	23.00	22.70	22.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.25	0.72	-4.29	15	574	2011-04-15 12:34:27	2011-04-15 13:34:27	1	75	127	0	119	497	104	67.10	22	14.25	CHANGED	VApoFluSsEFpp+YGs.slsscsaVssLYpNlLGRcuDtuGhsYWsupLssGsETRtElLLGFu-SsENcuLFoE	.......................................................pppal...p..plYpsll..sR...s..s..DtpGhpa.W.......h....s.......pL..p.....sG.t......o.......ht...phhh...th...h.pStEh.t....t....................................	0	33	86	99
+13789	PF13947	GUB_WAK_bind		Wall-associated receptor kinase galacturonan-binding	Coggill P	pcc	Jachmmer:Q8H7G7	Domain	This cysteine-rich GUB_WAK_bind domain is the extracellular part of this serine/threonine kinase that binds to the cell-wall pectins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.98	0.72	-3.48	243	1199	2011-04-15 14:01:02	2011-04-15 15:01:02	1	68	22	0	725	1166	0	107.00	22	20.37	CHANGED	hssC.s....s..p..C..Gs..l..s.IPYPFGI........G..s...s.....Chh......tuFp..lsC....ss...o.......s.st..lh.............tsshcVhs.IS.lt....p..........uplp....lhs.....sl....stpChs.sss.s...ph.......t.....sh..shst........s...........ahhSs.spNp.hssl.GCss	....................h..sC..s..p...p...C..G..s........l..s..IsYPF....G.l................s....s....s...........Csh............sFp...lsC....sss.........ts.st.lhh...............................ssshpV.hs....Is.....ht.....s....................sp...lp.lhs..........sh.....tt.shs..ssst............................hshsh.............s...................hh.h....s.t.p...N......h.h.hh.uCt..................................................................	0	34	326	531
+13790	PF13948	DUF4215		Domain of unknown function (DUF4215)	Punta M	mp13	Jackhammer:D0LZ65	Family	The function of this family is unknown.	27.00	21.50	27.00	21.50	26.90	21.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.69	0.72	-9.30	0.72	-3.74	207	1195	2011-04-15 14:50:47	2011-04-15 15:50:47	1	70	35	0	1101	1185	279	46.50	39	15.77	CHANGED	ChpC...p..p..G..ap.h..s......pptC........hshC....GDslls.......sp.....EpCD.Ds.......Ntht..h.D.....GC....hp......Cp	.......................................C...........G..a..h...............tt...C..............hshCGDGlls...........st......EpCD..DG............Nphs..t.D......GC......p.....Cp............................	0	1023	1028	1080
+13791	PF13949	ALIX_LYPXL_bnd		ALIX V-shaped domain binding to HIV 	Coggill P	pcc	[1] 	Domain	The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, Pfam:PF03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.	27.90	27.90	28.00	28.80	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.74	0.70	-5.45	97	602	2011-04-15 15:01:10	2011-04-15 16:01:10	1	17	285	9	420	611	2	282.60	22	30.37	CHANGED	lc.s.s.......slPt..slh..c.csppl...p.pp.su.........lpplppthpplp..plpppspphlscsp.chLctEppp-pphRppa.sp..pWs+......sSsph...ss..plppclpchcphlpp.AspoDsplppphcp..hppsl..plLststpp.................................l.pshl.Ps.s.p...t...........................ts....p.s.........pp....tltpL+p.hlpclpplcpcRpp..hhp.cL+.p...th.p..sD.hhsplL..t...hsp......ptt...........s.p.h..c.tlFppcLc+.acshpppl.ppshppQppllpplpps..ppph......h...p.t.+.......ps..ptps.......ppRpphl....pplp.sua.ptap-lhsslpcGpcFYssLtphlp.phpppspsastsR+tEt	....................................................................................................tlP..slh...pchttlp...pp..ss..............hppltp.hppltphhppspphLpc...........st...chLptEptp-pphRtpa.sp...pWpp.........................sSsph.....sp...plpp..c...hpcacphlpp.Asp.....uDsplppphpp..pp...ssl.....plLsts.pp..................................................l.ps..tl.Ps.s.p....t.................................ts...ps.......pt............ltpL+p.hlpclppl...cpcRpp..l.ppL+.p...th.p.pD..hsp.hL.h...h.tp..tst.....................s.p.....c.tlFppcLc+.aps.hpp.tl.ppshppQppllpplpps..tpph..........h...p..+.............ps..ptpt.......ppRppsl.............................ppLt.sua.ptap-lhsslp..cGpc.FYscLtphls.phpppspshs.sRctE....................................	0	137	221	346
+13792	PF13950	Epimerase_Csub		UDP-glucose 4-epimerase C-term subunit	Coggill P	pcc	Jackhmmer:Q3EAY3	Domain	This domain is the very C-terminal subunit of UDP-glucose 4-epimerase.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.17	0.72	-4.03	308	5379	2011-04-15 15:23:58	2011-04-15 16:23:58	1	13	3888	48	1359	4059	1160	61.00	38	18.14	CHANGED	AFE+AsG+plPYclssRRsGDl...ApsaADss+Apc-LGWcAp+.sL--MCpDsW+WQspNPsGY	.....................shc+soG+slP.h.c..l.s.s..R..RsGDh...ushhAss..sKAcccLGWc.sph.sl.-c.......hhpc..u..Wp.W....p..p...ppPpGa............	0	444	849	1142
+13794	PF13952	DUF4216		Domain of unknown function (DUF4216)	Coggill P	pcc	Jackhmmer:Q9LI66	Domain	This DUF is sometimes found at the C-terminal end of proteins carrying a Transposase_21 domain, Pfam:PF02992.	27.00	27.00	27.50	27.60	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.46	0.72	-4.50	55	725	2011-04-15 16:13:17	2011-04-15 17:13:17	1	77	16	0	338	760	0	76.00	44	8.30	CHANGED	lclpa....c.sttph......p.lsLF+CcWhcs.p..spsl+hD.chG.hspVshsphhh.....cc.-PFlLAsQssQVaYltcPp........ppsWplVh	.....................................a..-.sYssh..+VPLF+CpWVcl....p...ssGVhlD.-tG.hTsVDLsKlGY.........pDEPFVLAspVsQVFYVcD.s.............h....h..............	0	0	50	68
+13795	PF13953	PapC_C		PapC C-terminal domain	Bateman A	agb	Bateman A	Domain	The PapC C-terminal domain is a structural domain found at the C-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the C-terminal domain from PapC and its homologues. This domain has a beta-sandwich structure similar to the plug domain of PapC [2].	27.00	27.00	27.00	27.10	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.26	0.72	-4.33	301	5978	2011-04-18 16:06:12	2011-04-18 17:06:12	1	11	820	10	369	3683	29	67.20	28	8.66	CHANGED	hslp.tsGp.slPFGAp...V.............p.......s....p.........p.s..p........p...s.....G.lVGpsGplY..lsGls..s.pupL.pVpW..Gss...ppCplsas.....lstppp	..........lp.tsGp.slPFGAp......V.............p........s..p...........p.s..p............s..s.....G.lVu-sGplY..LsG.ls..t..supl.pVpW..Gpp....stpCplsap..hs....p............	0	32	99	245
+13796	PF13954	PapC_N		PapC N-terminal domain	Bateman A	agb	Bateman A	Domain	The PapC N-terminal domain is a structural domain found at the N-terminus of the E. coli PapC protein. Pili are assembled using the chaperone usher system. In E.coli this is composed of the chaperone PapD and the usher PapC. This domain represents the N-terminal domain from PapC and its homologues. This domain is involved in substrate binding [2].	27.00	27.00	27.60	27.40	26.90	26.20	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.90	0.71	-4.63	34	5788	2011-04-18 16:06:36	2011-04-18 17:06:36	1	9	775	12	327	3635	16	143.60	29	18.18	CHANGED	hpFssshLpss.....tss.DlShFpps.tthhPGpYhVDlhlNsphhs..ptplpFpstsst........h.sCLop-hLpphGlphcths...tht.ptsp.........tChs..hstlPtsshpaDhup.tpLslslPQshLt.pscshhsPppWDpGIsAhhlsYshsus	.........................FssphLpss......tpsh...D...L.S...p.Fpps...sth.PGpYp.VDlhlNsphhs..ppsl.pF.h.ssssp......................thhsClo...p.Lp.p.hGl..p...s.ss.h.s....t...ht...ttss..............................tCls....hph...l.ss.ushp..aD.h.up..pLslol.PQshlp.p.p.s.c.s..alsPppWDcGIs.AhhlsYshsu...............................	0	24	83	222
+13797	PF13955	Fst_toxin		Toxin Fst, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:Q9RLG7	Domain	Fst (faecalis plasmid stabilization toxin), also known as RNA I, is a toxic peptide. Its N-terminus forms a transmembrane alpha helix, its C terminus is disordered and is likely to be cytosolic. Its translation is inhibited by the antisense RNA, RNA II, which acts as an antitoxin [1,2].	36.00	36.00	36.20	36.30	31.90	35.70	hmmbuild  -o /dev/null HMM SEED	21	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.50	0.72	-6.41	0.72	-4.17	13	45	2011-04-19 12:12:39	2011-04-19 13:12:39	1	1	41	1	5	25	0	21.00	62	62.92	CHANGED	FspIIAPllVGlllpLlc+WL	.hpTIIuPIVVGVVLcllD+WL	0	0	1	2
+13798	PF13956	Ibs_toxin		Toxin Ibs, type I toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:C1P607	Family	The Ibs (induction brings stasis) proteins are a family of toxic peptides. Their expression is inhibited by the Sib antisense RNAs, which act as antitoxins [1].	27.00	27.00	33.30	33.00	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.06	0.72	-6.46	0.72	-4.07	4	33	2011-04-19 12:16:39	2011-04-19 13:16:39	1	1	15	0	5	21	0	18.80	77	64.41	CHANGED	MMKLVIILVVLLlISFsAY	MMKlVIILlVLLLISFsAY	0	5	5	5
+13799	PF13957	YafO_toxin		Toxin YafO, type II toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:Q47157	Family	YafO is a toxin which inhibits protein synthesis. It acts as a ribosome-dependent mRNA interferase. It forms part of a type II toxin-antitoxin system, where the YafN protein acts as an antitoxin [1,2]. This domain forms complexes with yafN antitoxins containing Pfam:PF02604.	25.00	25.00	28.40	28.20	22.70	20.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.48	0.72	-4.24	20	200	2011-04-19 12:19:10	2011-04-19 13:19:10	1	1	179	0	23	81	1	104.50	53	80.37	CHANGED	athacpsGs.hs...shhG+Dshaccs...sphh.sclpHlHlt..............t.pssW......h.phhQhpRTSD.saLVYs.thhssppahlluIl.cPsAHcps.......cppsh.hspltchAEpFppph	...........FISYKRDGV.LP...DIFGRDALYDDSF.TWPLIKFERVAHIHLA..................NsNNPFP..........PQLRQFSRTNDtuHLVYC..Q.GAF...DEQAWLLIAIL.KPEPHKLA........RDNNQ.MHKIGKMAEAFRMRF..............	0	7	13	17
+13800	PF13958	ToxN_toxin		Toxin ToxN, type III toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:B8X8Z0	Family	ToxN acts as a toxin, it is part of a type III toxin-antitoxin system. It acts as a ribosome independent endoribonuclease. It interacts with, and is inhibited by, the RNA antitoxin, ToxI [1,2]. Three ToxN monomers bind to three ToxI monomers to create a trimeric ToxN-ToxI complex [2].	25.00	25.00	25.40	25.40	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.03	0.71	-4.57	31	151	2011-04-19 12:21:31	2011-04-19 13:21:31	1	2	115	10	9	140	2	147.30	27	88.43	CHANGED	hclYpIsscYlsYL+ch.....Ds.+Vh.st...ppppRsalGlllplsshcYasPLSSPKpK+cp....................hcppl......shhKIpp.......phLGllplNNMIPV.-sp..lphlDlp......p.p-p+....Y+pLL.cphpalpp..spccItc+.AcplYpphhppt.............tlpptsssFplLEctsppY	......................phYplspcYlphLpph.....Dp......+V..s......tpp.+salGlll.p.l.s....shpYhsP.loSsKp.K+cp.....................................hp..sph......shhKl.p...........phluslplspMIPVscst...hptlshp..........p.pD..+....Yp..pLltpphpalpp......ppppI.hpp.upplYpphhppt.............hhpphsssFthLEchh.t...............	0	3	5	6
+13801	PF13959	DUF4217		Domain of unknown function (DUF4217)	Coggill P	pcc	Jackhmmer:Q1KS87	Domain	This short domain is found at the C-terminus of many helicase proteins.	27.00	27.00	27.30	27.50	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-9.03	0.72	-4.43	193	1332	2011-04-19 13:16:38	2011-04-19 14:16:38	1	18	316	0	937	1323	22	64.00	30	9.61	CHANGED	slppp.........l........cp.hlhpc.pltphAp+.........AFhSalRuYtpH..pt+.......pIF.plppL..clspl...AcuaGLhpsPphp..t	.......................lptplcp..hlhp.shtlpp..tAp+.........AFhS..........al+uYspH..ph+...............plF.pl..p..pL..cLscl.............A.pSaGLhpsP+h..................	0	329	530	778
+13802	PF13960	DUF4218		Domain of unknown function (DUF4218)	Coggill P	pcc	Jackhmmer:Q9M233	Domain	\N	27.00	27.00	27.20	27.30	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.50	0.71	-4.70	38	847	2011-04-19 13:36:45	2011-04-19 14:36:45	1	90	37	0	424	907	0	109.80	46	12.19	CHANGED	tsIscLshFFptlspKVl-sppLcpLpspll.sL..CpLEhhFPPSFFDlMhHLhlHLVcEs+lsGPlahR.MaPaERaMthLKuYVRNRA+PEGSIsEuYhsEEslEF....CscYhp-ss.sluh....sss+pcsph	................................................t.sl.cls.F.hptlsp.KllcsppLptLpspllpsL..s.p.h..EhhFPPoFFslMhHLh....sH...LVcp.hplhGPhah+pMaP.aE.RY.Mu.lLKpYVRNRA+.PEuSIscu.YsTEEslE....F....Cs-alp-hp.sIGlPtsR+-spl............................................	0	21	99	119
+13803	PF13961	DUF4219		Domain of unknown function (DUF4219)	Coggill P	pcc	Jackhmmer:Q9C740	Domain	This domain is very short and is found at the N-terminal of many Gag-pol polyprotein and related proteins. There is a highly conserved YxxWxxxM sequence motif.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	27	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.11	0.72	-7.21	0.72	-4.46	162	657	2012-10-02 13:37:57	2011-04-19 14:55:30	1	109	61	0	341	681	0	27.50	37	3.68	CHANGED	hsu.sNYshWsh+McshLpupc..lW.csV-	....hsG.sNYstWsh+MpsaLpupc.....lW.csVp.......	0	83	169	206
+13804	PF13962	PGG		Domain of unknown function	Coggill P	pcc	Jackhmmer:B9DG91	Domain	The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.	23.00	23.00	23.10	23.80	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.62	0.71	-4.46	259	1615	2011-04-19 16:12:26	2011-04-19 17:12:26	1	118	27	0	955	1566	0	108.80	26	29.59	CHANGED	pchhpctpphlhllAsLlATVTasAuhssPGGa..ps...................sGpslL...sph.tapsFhh.sNshAFssSlsslll..Ll....th................hpth..hhh..hhhhhhhlulh.ulhsAasuGshhs	....................p...hpctppslhllAsLlATVoa.sAuhssPGGh.htss.................................p.....p.sGpsllt....p........p...ta..tsF....hh.ssshAh....hsSlsslll..ll..t.th.........................pth...h..hhhhhhhhhhhshh.uhhsAahsu.hh.............................................................................	0	48	486	751
+13805	PF13963	Transpos_assoc		Transposase-associated domain	Coggill P	pcc	Jackhmmer:B3H612	Domain	\N	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.73	0.72	-3.99	127	878	2011-04-20 16:20:45	2011-04-20 17:20:45	1	73	23	0	549	900	0	68.40	41	9.37	CHANGED	RsWM..........thhop-ahcGlppFlphAhsphtppp.....pl.hCPCpcCpNthh...psp.pplppHLh.ppGF..hpsYph...WhpHGE	................................pWMY..........pRhop-ahcGVp.FlphApsptppt......hl.hCPCp.cC+Nph.....pss..cpl+tHLh.ppG.Fh.sYss...Ws.pHGE...........	0	1	262	285
+13806	PF13964	Kelch_6		Kelch motif	Coggill P	pcc	Jackhmmer:Q9CAE9	Repeat	\N	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.23	0.73	-8.85	0.73	-3.57	179	1811	2012-10-05 17:30:43	2011-04-20 17:50:05	1	393	387	0	1125	11207	344	52.00	22	10.77	CHANGED	hpt..ht.sh..ss..ss...s..t..l.alh..GGt.sp................sphhh.as.....p..o..p..p..ap.p...l..s.....s..h.....t....s...p	............h....tt.us...ss...hs.......s...c.....l.Ylh...GGh.ss................................thhsslht.ac....sp....o...p.....p.....Wp.p.....l...s......s...h.............................	0	462	599	827
+13807	PF13965	SID-1_RNA_chan		dsRNA-gated channel SID-1	Eberhardt R	re3	Jackhmmer:Q9GZC8	Family	This is a family of proteins that are transmembrane dsRNA-gated channels. They passively transport dsRNA into cells and do not act as ATP-dependent pumps [1]. They are required for systemic RNA interference [2,3].	28.70	28.70	29.10	29.10	27.90	28.60	hmmbuild  -o /dev/null HMM SEED	570	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.15	0.70	-13.15	0.70	-6.34	8	320	2011-04-21 14:52:42	2011-04-21 15:52:42	1	5	81	0	179	283	11	382.50	32	77.38	CHANGED	SEPhaaahp.......shsp.sssoVhlclsS-Dsl.ChsVSlQsusCPVaDhspslp.sapGhapTho++uuIhlpKp-as..ttFhVFsVlps-DssCopps......pp.ps....sNcsK....oIoFplsh.hpshp...YtsholshlhhlhohhL..lahs.lshplhpspppht..............ptslluhpPs.sop.p...........p.hsh....tpcp.sspssshcEpc....hsspph..pllhs+tsLpVuDLu+csp..phlKp+ShsYhapllslulFYsLPVlQ.LVlTaQ+hlspT..GcpDhCYYNFhCA+PL....hhlSsFNplhSNlGYllhGlLFlllshpRchpa..........sppaGlPpHaGLaYAMGlALIMEGlhSAsYHlCPNpsNFQFDTSFMYVIssLsMlKlYQsRHPDlsuoAYssFulLuV.slLsulIGlhs+ss.hlallFslIallsshhlSh...............phYahGshKl............................csRhhl.Ls..........................h.slsNauhhshGL....ph+...stDFusalLhlFhsNslLYlsaYhlMKl........lspE+IshpAllhhhLAllsWssAuaFFhpcsosWTcoPApSRphNp.CllLcFYDsHDlWHhhSAlAlaFTFhhLhslDDDLhsshRssIsVF	........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p.....h...................s.s.......hhhh.G..h.hh....p.....................................sh.........hhh.hh..uh.us.hp.CP.s..shp.a........hh.h..hh..a..R.............p...............h.....h.......h.................h......................hh.h.h....h...h..h..hh....h.hs...........h.h....t.........................................................................................h.h...................................................h..hhsh.hhh.......h............t.....th....hhh.hh..h....phhhYhhhYhh.Kh.........................h.t.c....p..h........sh....h....hhhh..h......hh......u......hh..a........t.....th..............ssA.SR.hNt.C.h.th.h....D.+Dh.hHh.suhshhh..h.h..........................................................................................................................................................................................	0	78	96	140
+13808	PF13966	zf-RVT		zinc-binding in reverse transcriptase	Coggill P	pcc	Jackhmmer:P93281	Domain	This domain would appear to be a zinc-binding region of a putative reverse transcriptase.	27.50	27.50	27.50	27.50	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.14	0.72	-3.67	117	1664	2011-04-21 16:16:41	2011-04-21 17:16:41	1	319	46	0	590	1605	0	79.10	24	12.48	CHANGED	pFSs+ssYph.l.pssss.ts...ap.pl......Whspsss.KhsFFsWhAshs+lhTtDpLp+...+.s.h..t..hs..spCh.LC.p.p.ppEohsHLhhpCshsp.tlW	.........................................ha...................................t..............t.ph..................Wp.t..p..s.P..K.lp.hF..h..W..h..h.hps.+..l........TtspLtc...+..s...h...t...hs......sh..C....h...C..t.t.tt.....EshpHlhh.pCshsttlW...........................................	0	51	342	453
+13809	PF13967	RSN1_TM		Late exocytosis, associated with Golgi transport 	Coggill P	pcc	Jackhmmer:Q39074	Family	This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localised to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface [1].	27.00	27.00	27.10	27.20	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.20	0.71	-4.67	177	1182	2011-04-26 11:55:49	2011-04-26 12:55:49	1	36	266	0	844	1140	1	153.80	22	17.75	CHANGED	slhsslshshsluhhhhhhFslL..Rhp.....hpclYt.PR....phht...........pppss....tuh........auWlsshhchs-ppllppsGLDAhlFLRah+hs.hplhhshsllshslLhPlN.......ss......ssttt.............................th.shhohuNl......psps...........thasallhsala....sh.hshahlhcE	................................................................................hhsshhhshhhhhhhhhhF........hL..R.p....................plYt.s+..........hhh..............................tptt.......puh...................................h.uWlhsh..hc.....h..s..-..ppllppsGlDAhhaLRah+h...........h.ltlhhshslls.....hslLlPlN................hs.............usthp.............................................................psh..spho.huNl.....psss.............................hhWsHslhualhhh.hshahlhp.....................................................	0	239	465	693
+13810	PF13968	DUF4220		Domain of unknown function (DUF4220)	Coggill P	pcc	Jackhmmer:Q9FHJ0	Family	This family is found in plants and is often associated with DUF294, Pfam:PF04578.	27.00	27.00	27.40	27.30	25.10	26.90	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.24	0.70	-5.35	29	828	2011-04-26 13:23:38	2011-04-26 14:23:38	1	24	16	0	517	735	0	247.10	18	46.39	CHANGED	LWlAYhhAD.lAsasLGhLohst.............sst.....pppLhsFWAPFLLLHLGG.DTITAa..ShEDNpLWhRHlLsLssQshhu...hYVhh+.ph...s..u..s.......lhsshlLhFlsGllKYuERs.hA...LptAuh.................pphtsphhp....tscssss.h....s.h......hhcph.t...h.p.tth.sph...hhh.t....................................pphsptphlhtAashhp.hhp.thas.s.hhh....s.........hpcp.ppst..th...hpph.......pt.........h.ppua+llElELuhhYDhLYTKsslla.............o.hhGhh....h....Rh........lolhsss.sAhhL......Fth............t.....spt........th.p..as....psDlhlTYlLLuGAllLElhullh.hlhSsWshshLpp...p......hh..hhs...............hhtthhphlph.................h...pp.R..WSsphuQYNLlptC.hcccs	...........................................................................................................................................................................................................................................hWs..h............h.s......t........................h.........h...hh.h........hh.hh.....h..............................................h....h.hh.h.shh.+..hh.+..h........h..st........................................................t..................................................................................................................................................................................................................................................h....t...................................................h...h.................................................................hh..plh...p.plsh.hh-hha.oth.hh..........................................h..h..h....h.................h...........h.hh...........h..........................................................................................t..h...l..s...hhhh.......hhh.-h....h....h....h.s...h...............................................................................................................................................................t.............................................................................................................	0	6	185	357
+13811	PF13969	Pab87_oct		Pab87 octamerisation domain	Punta M	mp13	pdb:2qmi	Domain	This domain was first characterised as the C-terminal domain of Pab87 serine protease from Pyrococcus abyssi [1]. The domain is reported to play a crucial role in Pab87 octamerisation and active site compartmentalisation. Its up-and-down 8-stranded beta-barrel 3D structure is reminiscent of the one found in lipocalins.	27.00	27.00	41.60	40.40	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.23	0.72	-3.90	6	15	2011-04-26 15:55:18	2011-04-26 16:55:18	1	2	14	8	11	15	0	95.70	34	22.07	CHANGED	Pc.ELPFhhREclL++LEGhYcGY+GTlcapVKscGDhLhL+shGth.pho.hsLhPE-lc........EDal+haTh..GtKh.VEFp......IcsscVcllaERY+LlK	.....Pc.ELPhlhhEchLc+LEGpYcuY+GTlchsVcscGDhLhl+utuchtpto.hsLhP--lc........-DascahTht.sGt+hsVEFp......hcsscVcLlhERa+LlK.	0	4	6	7
+13812	PF13970	DUF4221		Domain of unknown function (DUF4221)	Coggill P	pcc	JCSG_target-390208:A6KZ57	Family	This family of bacterial proteins contains highly conserved asparagine and cysteine residues.\	 The function is not known.	27.00	27.00	27.00	27.90	26.90	23.80	hmmbuild  -o /dev/null HMM SEED	333	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.12	25	101	2011-04-27 09:58:51	2011-04-27 10:58:51	1	1	42	1	34	143	0	317.50	18	85.45	CHANGED	lhhlhll..hSCusp......pcpp.t.................pshsLh..ps...cslsaslD-psh..........hshslt.h..p...........psscchLh.Fhs..ptp...plphhDLcst.cllcpI.hccE.GPNGIspsh..uhh..s.Dshalh.ss..th.plhhhsppGphhpphsh...pssp..........pht.tphst..hh.....ssh.th.p-shlahs.h.......httc.hpphhs.hAhlDlpspplchhsl.sh.s.hhpp..ht.......phss.....s....h..s.....pssh...ph..ssspllhShssssplah.......s.s..p......tcphphh.pss..uphh.....spht....phpss....pps....hsp.hhc...ths.ppspYuslhaDch+chYaRaup......tsps.tpt.h..p.pphslhlaDc-asllGEsp	............................h.hhlhll..huCspp......pppt...................................................tphpL...tp...cslthsls-phh..........h.htl..h..p...........psuccaLh.h.s..php..tplp..hhDlpst.clhcpl.hcc-..GPsul.s.thh..uhh.hshDuhalh.st...........plhhhs.ppGclhpphsh...pptt...........ph....thss...........psh..hh.tsp.t.h.ahs..................h..t.p.h.ppphh..hshhshps.....pph.ph.hsh...h.s.hhpp...........phts.....s....h...th.....phsh...sh..ptspllhua.spsplal.....hs...p......tpph.chh.shp..Sphh......sph......ph.ss..tp....hpthhp.....hhppspYtslhYDph+plaaRhsh.sh......tstp.h...........p.+ths.lhlhDp-aplluEp..........................................	0	26	32	34
+13813	PF13971	Mei4	MEI4-Rec24;	Meiosis-specific protein Mei4	Wood V, Coggill P, Eberhardt R	pcc	Pfam-B_78600 (release 24.0)	Family	This family of meiosis specific proteins is required for correct meiotic chromosome segregation and recombination [1]. It is required for meiotic DNA double-strand break (DSB) formation [4].	21.70	21.70	23.20	23.50	20.70	19.70	hmmbuild  -o /dev/null HMM SEED	375	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.04	0.70	-5.51	7	42	2011-04-27 10:11:47	2011-04-27 11:11:47	1	1	32	0	25	34	1	302.40	31	94.28	CHANGED	Mssp..p.........hhpT........+lAlAlAII+p+PsshsuRpaoEhLtptlppp-psWKpcsctLctclhpl+QcL......L.sp.sss.h..t.t.h.tcl.sQpshpt.sstshhcphtssss.p.ps........................p.sphsh-s.hst+hpFLpplhcL+shp......pph..phplh...........psuhpplLssLhphh+ss+....Lh.sphhppsltslsphhsphshpphhstpppp+lp-hhppLlphlLpppplsphpsQchlsppLlsL.upss..h..lIphLLoplpshscsL.phh.pp...sh.p.tt.......phDssphpNhahhahllEpllppp..t..h.....p....pph.tph-cplh.hu-tFPLFuhhL......................WRlGslLsusc	......................................hh..........+lAlAhAII+o+PsshssRpasp.Lt.phlpt...p-.ph+pphcsLchcshph+pcl..........L.s+h.tst.h.......t.t........t.h.spp.hps.sshs.hc.-ssss.s.p.p................................chspsshppsLos+hpFLQ+lLpL+shp......csst.p.hpls.hp.p..ppl..s-SV.pLLDuLlsFa......+pPK....hshsphhpcAlpsLsphlsshshspthhKps.K+LEEhpcoLlphILpsppINphpstp.hsp.Lhhl.......h..llphlL..lpth.p.L.................................hp....hh.hhptl..t..........................p......ptash.th.h......................hhlt.h.................................................	0	6	10	14
+13814	PF13972	TetR		Bacterial transcriptional repressor	Coggill P	pcc	JCSG:Target_399142	Family	This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.  The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription [1].	25.00	25.00	25.60	25.40	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.64	0.71	-4.76	102	573	2011-04-27 11:46:47	2011-04-27 12:46:47	1	2	496	2	150	441	87	146.10	26	66.69	CHANGED	ppYppplpphhpssps....tt..........sl....-shhhYlcslFphhWpYRFhap-LsslLs+stpLppcapp.htpphhpphttlhpthtptGllp.hsspc.lp..sLspslhllsoaWlsapp..stpsptt....hsptsltpGl..hpllsLhtPalsspuppthp	..................................pYpppl.phLp.sps..pp..........sl--hhtYLpslhshhWcYRFlapD.LscLLsRst.cLppcapp.htpch.hpph.hslhpthhst..ullp..hs............psp.lp..sLspshhllsohWlsapp..shp..pst....lscptlppGl....hphlslltPalpspuRpth.............................	0	36	71	113
+13815	PF13973	DUF4222		Domain of unknown function (DUF4222)	Bateman A	agb	Jackhmmer:B2PP87	Domain	This short protein is likely to be of phage origin. For example it is found in the Swiss:B6DZ51 Enterobacteria phage YYZ-2008. It is largely found in enteric bacteria. The molecular function of this protein is unknown.	21.40	21.40	21.90	25.00	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.90	0.72	-8.36	0.72	-4.56	30	595	2011-04-27 13:50:12	2011-04-27 14:50:12	1	1	284	0	13	250	0	52.30	37	64.10	CHANGED	shhphschY+D.ppGhhVplhussps..RVhahR.-GYpasCshPltpFpp-FphVp	.........hhphsphY+D.paGssVpIpplpcp..+VhYhR.-GY.a.sChhPlhpFpc-Fp.lp....	0	0	2	6
+13816	PF13974	YebO		YebO-like protein	Bateman A	agb	Jackhmmer:B2PQU2	Domain	This short protein is uncharacterized. It seems likely to be of phage origin as it is found in Swiss:Q9MCU2 and Swiss:Q9MCS4. The protein is also found in a variety of enteric bacteria.	27.00	27.00	30.70	30.60	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.82	0.72	-4.20	21	513	2011-04-27 13:58:43	2011-04-27 14:58:43	1	1	509	0	34	129	0	79.70	73	86.41	CHANGED	lslsllsllluLllWFFlNRASVRANEQIcLLcpll-QQKpQss.....LL.................p+Lspssp...tpst..s......custpssp.-atphIsER	...lVSlVVLLlGLILWFFlNRASSRsNEQIELLEALLDQQKRQNA.....LL.................RRLCEANE.....PEKscccss.......-S..pcusEDEDIIRLVAER..................	0	1	5	19
+13817	PF13975	gag-asp_proteas		gag-polyprotein putative aspartyl protease	Coggill P	pcc	Jackhmmer:B8H4J3	Domain	This family of putative aspartyl proteases is found pre-dominantly in retroviral proteins.	32.00	32.00	32.00	32.00	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.83	0.72	-4.15	40	832	2012-10-02 15:32:34	2011-04-27 16:57:49	1	76	77	0	189	1318	75	69.60	42	6.43	CHANGED	tshtptsphplpsplsu.hphp.sllDoGAots..hlspphAp+L.....uhshpths........hplp...hAsupstpspshhpshh	.......................h..hp-sGssTIoVhIGG..p.....hlc.pALLDLGASVN..LlPhslaKpL.....GLstLKsT................sloLp....LADpSl+hscGll-s..l..............................	0	53	73	124
+13818	PF13976	gag_pre-integrs		GAG-pre-integrase domain	Coggill P	pcc	Jackhmmer:Q8S892	Domain	This domain is found associated with retroviral insertion elements and lies just upstream of the integrase region on the polyproteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.52	0.72	-4.33	1103	1961	2011-04-27 16:15:09	2011-04-27 17:15:09	1	257	126	0	637	1866	6	69.40	23	6.66	CHANGED	sLYhl..sh..........p....p.h...s.s...........s...........s...s...........s.........s...........sp........p...s...........ss...shlWHpRLG.Hhuhp...tlpcLs..p..........th.....l...sth...s...h........p.....tp.......hCcsChhuKp	............................................................a.h................................t..................................h...........s...........h.................sp.........t....s..........................ss...shlWHpRLG.Hhuhp...tlpcLhp............pth......l......tsh...s...h............p.........tt.......hCpsC.huKp................................	0	184	260	364
+13819	PF13977	TetR_C_6		Bacterial transcriptional repressor	Coggill P	pcc	Jackhmmer:P17446	Domain	This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity [1]. Another target protein is BetI, an osmoprotectant which controls the choline-glycine betaine pathway in E.coli [2].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.28	0.71	-4.06	258	2956	2012-10-03 00:15:22	2011-04-27 17:17:06	1	10	1376	20	826	2207	181	109.00	18	54.34	CHANGED	P....ppRLpullcsshs..sthst..t...thps.WlsFaupu.hpss...phtclpphh.tpchcspLtthlp.....phhs.........stcscthAptlsAllDGL...alc.ssls.........tshs..hpput...plspphlsthls	.....................................................pthht...h...h...s....p.hs.......t..........shph...hh....phhut..u..h.+.pP....tl.t.pl....hp.tt....pchps.sL.s.phh.c.........pths............t...ps......p.....thu.ps....Ls....Ahl.-.Gl...hlc.hshs.......pshs....tpphh...phhpphlt....t.....................................	0	232	548	713
+13820	PF13978	DUF4223		Protein of unknown function (DUF4223)	Bateman A	agb	Jackhmmer:B2PGT1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. These proteins are likely to be lipoproteins (attachment site currently included in alignment).	27.00	27.00	43.80	43.80	25.90	21.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.85	0.72	-4.24	6	435	2011-04-27 16:27:16	2011-04-27 17:27:16	1	1	432	0	13	47	2	55.40	89	99.28	CHANGED	MpKhlKlAlluuVLo...oLTACTGHlpN+cKNCSYDYLLHPAISISKIIGGCGP....sApQ	........MNKFIKVALVGAVLA...TLTACTGHIENRDKNCSYDYLLHPAISISKIIGGCGP....TAQ..............	0	1	3	8
+13821	PF13979	SopA_C		SopA-like catalytic domain	Bateman A	agb	Jackhmmer:B2PGH8	Domain	This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes. This domain contains the active site cysteine residue.	25.00	25.00	25.70	32.90	19.10	24.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-10.90	0.71	-4.65	9	234	2011-04-28 08:31:54	2011-04-28 09:31:54	1	9	189	13	6	132	0	163.80	49	24.43	CHANGED	.hcscLcshFhpAhppspsplKhl--tpp.pcLtpla.ph...psh.ptapLpscHappIlshYsLsshocpcKAEILFsLusVFs+YSSSslFGsEhDSPphLRtYApALhpKAacLDPplh.opppFs-WpsRLlGpssuF....TC..TulLtspMhcHAcppFsslLpplhPsAWR	.............................................................t.p+GcLpptFluAhspK+SsVKhlsDss..o+LsolF............ss.hhsptpLs....stHYppILoua.....cLsDAo..pKQAEhLFCLSssFA+YSSSslFGTEaDSP.sLRtYApALhpKAacLsPulFsS......s...ppFs-apDRhp.Ghps.sF....TC..TSVlsDsM....pRH..A+c.hFPpVLSphhPlAWt...................	0	1	1	4
+13822	PF13980	UPF0370		Uncharacterised protein family (UPF0370)	Bateman A	agb	Jackhmmer:B2PE90	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved DWP sequence motif.	27.00	27.00	27.90	63.70	24.00	23.50	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.21	0.72	-4.15	13	533	2011-04-28 08:38:11	2011-04-28 09:38:11	1	1	532	0	39	98	0	65.30	86	99.09	CHANGED	MpWL.ADYWWl.ILLlLlGlIlNuIK-LpRlDtK+FLcNKP-LPPHRDNNcpWDDED.DWPp..cKK+	.........MDWL.AKYWWILVlVFLVGVLLNVIKDLKRVDHKKFLANKPELPPHRDFNDKWDD.D.D.DWPK..KD..QPKK.	0	1	8	23
+13823	PF13981	SopA		SopA-like central domain	Bateman A	agb	Jackhmmer:B2PGH8	Domain	This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [1,2]. These proteins have been shown to act as E3 ubiquitin ligase enzymes.	27.00	27.00	28.20	29.30	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.64	0.71	-4.14	14	461	2011-04-28 08:38:40	2011-04-28 09:38:40	1	13	337	13	6	257	0	135.00	39	23.85	CHANGED	splKschsccLlpsLspsplslsp..sh.s..LhsIhucssYlpsspIp.palpplp-sahpshsp..............hshhcppspllpshlshFs......+pP-hMlst..NusFIQhlhtshtpt..ssshpppAtcLYppYLphsplp.hhpps-	.............................................h...KshhshcLVhQL..phLshssh.phlEs..h+chhSHsPYIpsslI+.SaI+ssc-shF-shhppa...........Rhscssassp.h.tFlspFs......hNptLhspp..NshFIQlIspshcus..sDth+ppAhtLYcpalppscVSPhhhp.................	0	1	2	4
+13824	PF13982	YbfN		YbfN-like lipoprotein	Bateman A	agb	Jackhmmer:B2PG20	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length. Members of this family are lipoproteins.	27.00	27.00	35.70	35.60	22.20	19.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.92	0.72	-3.80	7	463	2011-04-28 08:44:07	2011-04-28 09:44:07	1	1	455	0	19	107	1	88.00	88	81.76	CHANGED	QssAP.EDu+.LKpAYSACINsA-GSP-KltuCQuVLsVLKp-KtHQtFAppEoVRVLDYQpCIpAspTGNsQshsApCsKlWQEIRuNN	.............QSTAPQEDSR.LKEAYSACINTAQGSPEKIEACQSVLNVLKKEKQHQQFA-QESVRVLDYQQClpATQTGNDQAVKADCDKVWQEIRSNN................	0	1	3	9
+13825	PF13983	YsaB		YsaB-like lipoprotein	Bateman A	agb	Jackhmmer:B2PHF9	Family	This family of proteins is functionally uncharacterised. These proteins are related to E.coli YsaB Swiss:Q0TBP2. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. These proteins are lipoproteins.	27.00	27.00	27.00	32.00	22.20	22.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.67	0.72	-3.82	9	447	2011-04-28 08:46:45	2011-04-28 09:46:45	1	1	445	0	15	112	0	76.10	88	78.93	CHANGED	PsQKAQ+sKVSPpRoLsMEpLCK-QAA+RYNTssQKIDVTGFEQFQGSYEMRGpThRKEuFVCSFDA-GQFLHLSMR	.....PVQKAQRVKVDPLRSLNMEALCKDQAAKRYNTGEQKIDVTAFEQFQGSYEMRGYTFRKEQFVCSFDADGHFLHLSMR	0	1	1	8
+13826	PF13984	MsyB		MsyB protein	Bateman A	agb	Jackhmmer:B2PRZ7	Family	The MsyB protein has been found to be able to restore protein export defects caused by a temperature-sensitive secY or secA mutation [1]. However, its exact molecular function is still unknown, but it may play a role in protein export. Proteins in this family are approximately 120 amino acids in length. This family of proteins is found in bacteria.	27.00	27.00	68.40	68.30	25.00	18.40	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.48	0.71	-4.08	7	458	2011-04-28 08:52:19	2011-04-28 09:52:19	1	1	455	0	27	99	2	121.30	91	97.87	CHANGED	MYsTL-EAIDAAREEFLAsp.t.--D-ssV.sQFNLQKYVMQDGDIMWQAEFFtDEs-pGEClslhSGtAAQAIFDsDYDElElRpEW.sENTLHEWD-GEFQL-PPLDoEEGcAAAsEWD-c	.MYATLEEAIDAAREEFLADNPG.I.DAE-.ANV.QQFNuQKYVLQDGDIMWQVEFFADEGE.EGECLPMLSGEAAQSVFDGDYDEIEIRQEWQEENTLHEWDEGEFQLEPPLDTEEGRsAADEWDER.	0	1	3	15
+13827	PF13985	YbgS		YbgS-like protein	Bateman A	agb	Jackhmmer:B2PG89	Family	This family of proteins is functionally uncharacterised. The family includes the YbgS protein from E. coli Swiss:P0AAV6. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. Some members of this family are annotated as homeobox protein, but this annotation cannot be verified.	27.00	27.00	28.90	28.60	24.50	22.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.71	0.71	-4.22	9	467	2011-04-28 08:58:10	2011-04-28 09:58:10	1	1	463	0	22	92	0	123.50	85	98.29	CHANGED	MsKLAoLFLTAshoLASGAALAADosuposNGpANuAADAGtVAPsAKpNlAPNNVDNopINTsss.........Go.hpsss....ohspcsMopDElHKNoMCKDG+CPDhNKKVpsttu.ss-ssTKTDGTTQ	....MTKLATLFLTATLSLASGAALAA.DSG..AQ...oNNGQANAAADAGQVAPDAREN..VAPNNVDNNGVNTGSG....................GTM.LHsDG.......SSMNNDGMTKDEEHKNTMCKDGRCPDINKKVQTGDGINNDVDTKTDGTTQ...................................................	0	1	2	12
+13828	PF13986	DUF4224		Domain of unknown function (DUF4224)	Bateman A	agb	Jackhmmer:B2PT37	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and viruses, and is approximately 50 amino acids in length. The protein is likely to be of phage origin and is found as protein Gp02 Swiss:C8CLF5 in the Xylella phage Xfas53 [1].	21.30	21.30	21.30	22.20	21.20	19.40	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.11	0.72	-4.41	38	290	2011-04-28 09:01:39	2011-04-28 10:01:39	1	2	222	0	30	167	2	46.30	37	53.99	CHANGED	thLTccElt-LTGh+.......ptupQtchLcpp.GI.ahhpscG+PlVsRpalp	....hLTcsEltpLTG.hc................hto+QpchLpcp.GlsFhhst.s.G...cPlVsRphh....................	0	4	16	28
+13829	PF13987	YedD		YedD-like protein	Bateman A	agb	Jackhmmer:B2PRC7	Family	This family of proteins related to the YedD protein is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length. These proteins are lipoproteins.	27.00	27.00	33.90	63.30	21.60	18.30	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.89	0.72	-10.41	0.72	-4.49	10	460	2011-04-28 09:05:55	2011-04-28 10:05:55	1	1	457	0	23	121	2	110.60	86	80.58	CHANGED	VVKTPAPAtLsGYWQopGPQSuLVSP-AIASLlVTp-GDTLDCRQWQRVIAhPGKLTptsD-hhNVTpKh-VYsLEh-GssLEYDGMTLpRVDRPTsECtphLsKt....PLssP	..VVKTPAPDWLsGYWQTKGPQRALVSPEAIGSLIVTKEGDTLDCRQWQRVIAVPGKLTLMSDDLTNVTVKRELYEVERDGNTIEYDGMTMERVDRPTAECAAALDKAPLPT.P........	0	1	2	13
+13830	PF13988	DUF4225		Protein of unknown function (DUF4225)	Bateman A	agb	Jackhmmer:B2PH01	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 182 and 282 amino acids in length.	24.10	24.10	24.40	24.60	23.60	24.00	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.99	0.71	-4.79	24	185	2011-04-28 09:36:09	2011-04-28 10:36:09	1	5	122	0	37	140	1	160.80	32	59.07	CHANGED	Ippl+pEppsLccQsphlpppphp.hh.hph............cppphhthhltulGlVuGGsQlhuGhulh...hso......tsshsthhGusLlscGsNslhEsshtlh...tcp..........shpG.l+cuYcpsAp.hlGhscpsushsYssVDluhShYGhhphh........................lp......P..ssaRLa+.YlssDah+thpp.....MopstL	...............................p.lp.E.tphppp.phhpttphchalpsch............EcpplIsYVhtulslVs...uGhQlVuGsGhl...hss......tssluhhsGshLlhcGANslhEuhthLh.....hsc..........psoG.lccsYtssAc.hhGhsp.psu.huYpslDluhShYGhhphh................................h+......P..sshRLa+.YlssDahpphpphsp............................	0	1	11	18
+13831	PF13989	YejG		YejG-like protein	Bateman A	agb	Jackhmmer:B2PI82	Family	The YejG protein family is a group of functionally uncharacterised proteins related to Swiss:P0AD21. This family of proteins is found in bacteria. Proteins in this family are approximately 110 amino acids in length.	27.00	27.00	58.50	58.40	20.30	19.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-10.27	0.72	-3.98	16	534	2011-04-28 09:51:31	2011-04-28 10:51:31	1	1	532	0	39	115	1	106.00	82	93.71	CHANGED	lQLSVVHRLPQSYRWloGasGsKVEPlP..sshss-ssLlGLKLLSHDGssAWplMcpLppoLs-IQlssullEWEGEPCLFl++pDESAshCRLKNhGVAIAEshsu	.......LQLSIVHRLPQNYRWSAGFAGSKVEPIPQ.NG...s.s............s.DNSLVALKLLSPDGDsAWSVMaKLSQALSDIEVPCSVLECEGEPCLFVNRQDEFAATCRLKNFGVAIAEPFSN..	0	1	9	24
+13832	PF13990	YjcZ		YjcZ-like protein	Bateman A	agb	Jackhmmer:B2PJH4	Family	This family of proteins is functionally uncharacterised. The family includes the YjcZ protein from E. coli Swiss:P39267. This family of proteins is found in enteric bacteria. Proteins in this family are approximately 300 amino acids in length. There are two conserved sequence motifs: FGD and MPR.	27.00	27.00	28.10	27.60	22.70	22.30	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.60	0.70	-5.26	10	540	2011-04-28 09:57:24	2011-04-28 10:57:24	1	1	319	0	13	209	1	258.80	62	90.92	CHANGED	hVDLApG.-ss+sththtppp.pFRpRLppplhupophRpashsushupsLthsLpLlEcLsu.LsPGHLALTplsc+LspLppssustAphossltpQLtsLs-paspRssahEcsLsptsLhspAtcHsEQIFoRWRAGcYsuWSLsGRCYlALEELRWGAFGDACR.LussshsshLlDsLRs....cAsptLApslpAuPsTRHaYHpWLs.ssstsuss-asDhLuWLGDWCssD+HPVsWSVTQpWQsVuLGMPRLCSAcRLu-AMVEEIF	...............lVDhApG.Dst..p...Atpp..pFhcRLhptLhucsthpp.s.su.LstslphpLphlpcLso.LsssphAlTpls.........p+lu.L.p..stR.tph........s-h.pQlhsLh-.hpt+hpahEctLpphs.l.pAt.p.EQIFohWpAGt.YsuaS.sGRCalsLEELRWGAFGDshR..Gps.ttVs.LLs.LRh....KAhpplApp.suusTsRh..hhpWhu.pup......sss-atDhlsWLGcWsot-+pPVhWSsTQthpplsltMPRLCSApRLutuMV-EIF..................	0	1	2	6
+13833	PF13991	BssS		BssS protein family	Bateman A	agb	Jackhmmer:B2PS04	Family	The BssS protein family is a group of proteins that are involved in regulation of biofilm formation [1].  Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	40.70	40.40	26.80	22.00	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.32	0.72	-4.25	16	542	2011-04-28 09:57:45	2011-04-28 10:57:45	1	1	527	0	44	132	1	71.10	83	86.86	CHANGED	HPlVGWDISTVDuYDAhMlRLHYLSotpQs.EsApVscThWLTTDlA+QLIsILpAGIsKIEou-htssshp+	.HPLVGWDISTVDSYDALMLRLHYQTPN+sE.pE.GTEVGQTLWLTTDVARQFISILEAGIAKIESGDa.sNEYR.R......	0	2	10	27
+13834	PF13992	YecR		YecR-like lipoprotein	Bateman A	agb	Jackhmmer:B2PR21	Family	The YecR-like family of lipoproteins includes the YecR protein from E. coli Swiss:P76308. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 110 amino acids in length.	27.00	27.00	27.20	43.20	26.70	24.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.72	0.72	-3.81	19	390	2011-04-28 10:03:24	2011-04-28 11:03:24	1	1	385	0	20	105	2	73.10	73	71.33	CHANGED	ssuSpssGlVcLuYp.....uhhpss.psDthtutthAspcCppWGYssAcsFGpss....psCshhsGph.....ChspplTlpYQC	..S.EssssoGIVRLsY-....QAaLQ+A..+TDcYVS+GlA-RACQQ.GYocAlPFGQPV....GsCSLaAG.SL.....CLNTcFTLSYQC...	0	2	2	12
+13835	PF13993	YccJ		YccJ-like protein	Bateman A	agb	Jackhmmer:B2PKP7	Family	The YccJ-like family of proteins includes the E. coli YccJ protein [1] Swiss:P0AB14 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	75.10	75.00	25.20	24.40	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.24	0.72	-3.90	6	468	2011-04-28 10:07:47	2011-04-28 11:07:47	1	1	467	0	26	65	2	68.90	92	92.19	CHANGED	KsHHVuEWAsVRcTSsEIAEAIFElAphDEpLAEcIWE.EGSDEVL.hAFuKTscDpLaWG-cTlERKNV	...KAHHVGEWASLRNTSPEIAEAIFEVAGYDEKMAEKIWE.EGSDEVLVKAFAKTDKDSLFWGEQTIERKNV....	0	1	3	15
+13836	PF13994	PgaD		PgaD-like protein	Bateman A	agb	Jackhmmer:B2PKR8	Family	This family includes the PgaD protein from E. coli Swiss:P69432. The homopolymer poly-beta-1,6-N-acetyl-D-glucosamine (beta-1,6-GlcNAc; PGA) serves as an adhesin for the maintenance of biofilm structural stability in eubacteria. The pgaABCD operon is required for its synthesis and export. It has been shown that PgaD is essential for this process [2].	27.00	27.00	33.80	33.70	25.60	24.10	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.70	0.71	-4.69	34	382	2011-04-28 10:23:42	2011-04-28 11:23:42	1	4	353	0	38	146	4	123.60	45	83.02	CHANGED	LIIspp+hhs..p+hhshhlThhhWshalaLhhsh...hlhhhlsht.hht.h..htshtsthtslthahhlhlhsuslLlhWApYNphRapscp++ph.....ls.c-lAppasls..pptlpphpps+lhs.la.aD-cGclhp	.......LIIspppp.s..phhlDhlsTslhWshFhhhlhhhh..llht.............ahapSputopLpaYhLLAlANAVVLIlWAhYN+L...RFQcpp++Ashp.....hospEY.....AcSLAlP...-ELhQQLQKS++hoVHasspGpIp.h..........	0	8	20	28
+13837	PF13995	YebF		YebF-like protein	Bateman A	agb	Jackhmmer:B2PQW6	Family	The YebF-like protein family appears to be a group of colicin immunity proteins. As well as YebF the family includes cmi, the colicin M immunity protein [1]. This domain family is found in bacteria, and is approximately 80 amino acids in length. The alignment contains two conserved cysteine residues that form a disulphide bond in the solved structure [3].	27.00	27.00	28.60	28.90	25.90	25.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-9.81	0.72	-3.97	23	531	2011-04-28 10:25:30	2011-04-28 11:25:30	1	2	485	4	22	151	1	88.40	73	73.86	CHANGED	RssKhsuCssLspsQlAApVKcDFLQNRIsRWssD+.KtLGpscP.VsWlssp-I...sGc-ssapVPLTVRGs+sD+pYpVhlDCpsGTIoYs	....p.SVpFPpCEGLDAAGIAASVKRDYQQNRlsRWADDQ...KlVGQADP.VAWVslQDI...pGK.DDKWoVPLTVRGKSADIHYQVsVDCKAGhAEYp.....	0	1	6	14
+13838	PF13996	YobH		YobH-like protein	Bateman A	agb	Jackhmmer:B2PQU4	Family	The YobH-like protein family includes the YobH protein from E. coli Swiss:Q2MB16 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There are two conserved sequence motifs: GYG and GLGL.	27.00	27.00	31.60	31.40	20.10	17.60	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.22	0.72	-4.05	15	454	2011-04-28 10:29:34	2011-04-28 11:29:34	1	1	451	0	30	97	1	69.00	76	88.65	CHANGED	+hlIRslllLAllWlulLhSGYGVLlGSpcNsAGLGLQCpYLTARGhsTAQYlHoDSGlIGlo-CPLLRK	..RhIIRslhLlALVWIGLLLSGYGVLIGSKcNAAGLGLQCpYLTARGTSTsQYLHTcSGhlGI.oDCPLLRK..	0	1	6	18
+13839	PF13997	YqjK		YqjK-like protein	Bateman A	agb	Jackhmmer:B2PL82	Family	The YqjK-like protein family includes the E. coli YqjK protein Swiss:Q47710 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a single completely conserved residue R that may be functionally important.	27.00	27.00	28.00	27.50	25.50	25.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.27	0.72	-3.80	39	560	2011-04-28 10:34:02	2011-04-28 11:34:02	1	2	555	0	59	168	6	72.30	73	73.50	CHANGED	LLppIpQQRh-LusptppWhchTsshDRuWpplh....phRpahh.luuulhAlhulR+.Pp+lhRau+R.uhusWushR	....LLSQIQQQRLDLSAS..R..R-WLEsTGAYDRtWNhLL....SLRSWAL.VGSSVMAIWTIRH.PNMLVRWARR.GFGlWSAWR.......	0	6	25	41
+13840	PF13998	MgrB		MgrB protein	Bateman A	agb	Jackhmmer:B2PQU3	Family	The MgrB protein is a short lipoprotein.  The mgrB gene has a mg2+ responsive promoter [1]. Deletion of mgrB results in a potent increase in PhoP-regulated transcription [3]. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC.	27.00	27.00	33.40	49.50	19.30	18.60	hmmbuild  -o /dev/null HMM SEED	29	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.88	0.72	-7.32	0.72	-4.17	14	404	2011-04-28 10:41:38	2011-04-28 11:41:38	1	1	401	0	18	57	0	29.00	90	61.90	CHANGED	LYLlAlsshCDQG.tpFh.GICsITcalPa	LWAQVFNMMCDQD.VQFFSGICAINQFIPW	0	1	2	10
+13841	PF13999	MarB		MarB protein	Bateman A	agb	Jackhmmer:B2PLW6	Family	The MarB protein is found in the multiple antibiotic resistance (mar) locus in Escherichia coli. The MarB protein is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved GSDKSD sequence motif.	27.00	27.00	28.10	28.00	21.50	20.40	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.06	0.72	-4.39	10	439	2011-04-28 10:46:09	2011-04-28 11:46:09	1	1	435	0	13	87	1	65.30	69	90.91	CHANGED	uuAslsLLlLsSGQuhAEQTppPsspsscDslllPsupcQSPFDLNHMuAGSDKSDELGVPYYNp+	..SAIAuALILFSAQGVAEQTsQPVVTSCusVVVVPsSQEQPPFDLNHMGTGSDKSDALGVPYYNQp...	0	1	1	8
+13842	PF14000	Packaging_FI		DNA packaging protein FI	Bateman A	agb	Jackhmmer:B2PPD2	Family	This family includes the lambda phage DNA-packaging protein FI. Proteins in this family are typically between 124 and 140 amino acids in length.  There is a conserved EEE sequence motif.	27.00	27.00	29.10	28.90	22.30	21.20	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.39	0.71	-3.93	13	521	2011-04-28 10:50:25	2011-04-28 11:50:25	1	3	289	0	3	215	0	120.80	49	94.02	CHANGED	TKEc.lpRLcELAshLGREsDhSGSuA-lAQRVAEhEEEls.............suss-ssssccss.supp-psssspsp.....tsps-hVpVcsLtoLHhsAlcsssscsV.phV.sGpslhVsussAsshlssGLA	.......TK-E.ltRLcpLut.LsR-ssloGottElA.RVAEhEEELs.............suupDs.susE...huccs...pssosps-pl.......psousLssVhsLssLHssulcsppsEPV.thVhsGpshhVsuulAspMs-+GhA...................................	0	0	0	1
+13843	PF14001	YdfZ		YdfZ protein	Bateman A	agb	Jackhmmer:B2PLX9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There is a conserved YDRNRN sequence motif. The E. coli protein has been shown to bind selenium [1].	27.00	27.00	27.40	27.40	21.90	20.20	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.06	0.72	-3.70	11	477	2011-04-28 10:55:07	2011-04-28 11:55:07	1	2	463	0	21	77	1	63.40	78	94.39	CHANGED	+sYDRNRNAIosGsRVMluuoGpsGVIKAIHu-GhospQlRRuKsVplcGs-t+asPl-LlRLG	.....pTYDRNRNAITTGSRVMVSGTGHTGhIhuI-oEGLTAEQIRR...GKTVlVEGCEEKhAPlDLIRLG...........	0	2	6	12
+13844	PF14002	YniB		YniB-like protein	Bateman A	agb	Jackhmmer:B2PNH1	Family	The YniB-like protein family includes the E. coli YniB protein Swiss:P76208 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 180 amino acids in length. This family of proteins are integral membrane proteins.	27.00	27.00	30.40	30.00	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.86	0.71	-4.79	20	546	2011-04-28 10:57:37	2011-04-28 11:57:37	1	1	541	0	42	162	4	162.50	80	91.65	CHANGED	lhGWllFIPALlSTlISllphhat+u-ctpGINAVh.DFh+lMl-MlRFNTPFLNhFWpNSPlPsasth..uuuNlhFalIYlLIFVGLALpASGuRMuRQl+aIREuIEDQLILEpAKGs-GhTRppLEp+IslPR.HTIFlQhFsLYlLPlllullGYhhlKLLGh	..IlGWVIFIPALlSTLISLLKFM.s+pEpQEG......INAVMLDFTHVMIDMMpsNTPFLNlFWYNSPTPNFs.....GGlNlMFWlIFILIFVGLALQDSGARMSRQARFLREGVEDQLILEKAKGpEGLTREQIESRIVVPH.HTIFLQFFoLYILPVIsIssGYhFFSLLGF................................	0	2	10	25
+13845	PF14003	YlbE		YlbE-like protein	Bateman A	agb	Jackhmmer:O34958	Family	The YlbE-like protein family includes the B. subtilis protein YlbE Swiss:O34958 which is functionally uncharacterised. This family of cytosolic proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a conserved WYR sequence motif.	27.00	27.00	43.10	42.90	22.90	18.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-9.19	0.72	-3.89	14	143	2011-04-28 13:02:23	2011-04-28 14:02:23	1	1	143	0	20	63	0	64.70	64	81.46	CHANGED	p.-L+pFIRppPhWYRpLoRpPpplsshEh-AhpaYcKTlPc+V-+hssslpMApMMhpMhpAM+	..D.EDLsRYIREQPaWYRKLoRNPEEhEAFELAAMpHaKKTIPDKVEKFQNQLulASlMI-MFQhMK...	0	3	12	14
+13846	PF14004	DUF4227		Protein of unknown function (DUF4227)	Bateman A	agb	Jackhmmer:C0H451	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	33.30	33.10	26.50	26.00	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.28	0.72	-4.14	18	158	2011-04-28 13:05:32	2011-04-28 14:05:32	1	1	157	0	29	79	0	70.90	58	90.84	CHANGED	+plhcslKVFlLFTGsTlLFYYullWlscEYpsYHRYDEPcGsAVKVhphpssp.ph..sa.h-RLhhFYhsGE	.........KhsaDuIKVFLLFTuCTILFYaAILWlN-EYEsYHRY-KPKtcsVchV..ous..c....EPsKD....ua.lsRhhFFYcNGE.	0	7	19	21
+13847	PF14005	YpjP		YpjP-like protein	Bateman A	agb	Jackhmmer:P54172	Family	The YpjP-like protein family includes the B. subtilis YpjP protein Swiss:P54172 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length.	27.00	27.00	56.80	56.00	25.50	18.40	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.89	0.71	-4.40	15	144	2011-04-28 13:07:43	2011-04-28 14:07:43	1	1	143	0	23	80	0	136.90	68	68.73	CHANGED	ssc.spppahct.lhppA.cQSh.hKFGsKIuPhIE-Ea+chILPKlEcsIs-hlsphs---.LppLslS-sPuuGpGEKIFHlYsp+TG-DllRFHVRRD+PPpcGYaFNFHYHot-DsFpsHHELGsIYWcKNTPPpW	........s.+LTsDTFIsY.AMQEAEKQSM.pKFGoKIGPVIEDEFKDVILPKIEEAIAELAs-VPE-.S.LQSLA.ISpKP.AGGNsEKIFHVYDTKTGsDLLRFHVRRDHPPQDGYYFNFHYHcaDDGYouHHELGsIYWNpNsPPKW...	0	6	15	17
+13848	PF14006	YqzL		YqzL-like protein	Bateman A	agb	Jackhmmer:C0H452	Family	The YqzL-like protein family includes the B. subtilis YqzL protein Swiss:C0H452 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	27.00	27.80	26.30	26.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.54	0.72	-3.76	20	174	2011-04-28 13:10:03	2011-04-28 14:10:03	1	1	174	0	37	81	0	44.00	51	92.99	CHANGED	DFoWKlFupTGsIDoYLLaKE....lEccsc.p.sppppE...pchs...shp	...DFTWKhFSpTGSI-TYLLhKE....hE+-sp-ch-pcE-E..hsclD.sh.s.............	0	18	29	31
+13849	PF14007	YtpI		YtpI-like protein	Bateman A	agb	Jackhmmer:O34922	Family	The YtpI-like protein family includes the B. subtilis YtpI protein Swiss:O34922 which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 101 amino acids in length.	27.00	27.00	36.20	35.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.66	0.72	-4.06	24	163	2011-04-28 13:12:27	2011-04-28 14:12:27	1	1	162	0	30	111	0	80.50	53	87.64	CHANGED	hlhlIlhShshYlYaKl+t.hRopcshc+phasuKusluLGlFlhhFulNQhhl...hpoTlshlluhlFlllGhushatGa+sa+HYhPhht	...........................................hhlhhoh.hhhaaph+..h+st...shEK........tahSuKSuMALGoFVLFFGINQaFL...phSTsclI.VGllFlLhGuuSlasGaRpYKHahPLA.l......	0	9	21	24
+13850	PF14008	Metallophos_C		Iron/zinc purple acid phosphatase-like protein C	Coggill P	pcc	Jackhmmer:Q9LMX2	Domain	This domain is found at the C-terminus of Purple acid phosphatase proteins.	23.00	23.00	23.00	23.00	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-8.93	0.72	-3.89	130	888	2011-04-28 16:05:58	2011-04-28 17:05:58	1	20	198	20	604	904	23	64.20	29	12.89	CHANGED	pAPlaIlsGsuGs.....th...ss.....hs..p....s....p...ssao.s.h....cp...s.caGauplphhNpTcLpacalc.s..p...s.........G..p..V..hDph	.....................................uPlalshGsu...Gs...........hh...sp...................hh.p...........s....p...PsaS.sa.........Rp....s.saGaupLplh.NpT....+hhapahc.s.p...D.........G..p..l..hDp.................	0	189	377	518
+13851	PF14009	DUF4228		Domain of unknown function (DUF4228)	Coggill P	pcc	Jackhmmer:Q8GY70	Family	This domain is found in plants. The function is not known.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.22	0.71	-4.14	56	732	2011-04-28 16:07:15	2011-04-28 17:07:15	1	4	27	0	458	690	0	161.80	16	86.36	CHANGED	MGNslsssh.......stssssss+llh..sGplcch..pt....sls..AuElhtphPsHh................sss....tp...s....s.....pclt.........sLssDccLphG..clYallPhpp.htst.hstps....hs..plt....ht..sspstpp........htttpsp.h...............t........ppssss.sp.h.......hh...hhs.cppl...pchh.............p..pt.........sspt..hsp.h......tptt............hp...ppp....p.tspspsW+PpL-oIsE	......................................................MGst.t......................t.tss+lht.........s...........G.plpch......th.............s..hp..suclh....t.t........P.s.p.h.l.............................stsps..ht...h..........s....................tph................hl.t..scppLp.G..plYall.Phpp.h...p.....hpttp.............hs..tht.........ht......sttthtt.....................ttt.tp.h..............................................................tttst...ht.......................t.h....tphh........................................t.....................t...................................................................................h...................................................................................................................	0	45	266	375
+13852	PF14010	PEPcase_2		Phosphoenolpyruvate carboxylase	Coggill P	pcc	manual	Family	This family of phosphoenolpyruvate carboxylases is based on seqeunces not picked up by the model for PEPcase, PF00311. Most of the family members are from Archaea.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	491	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-12.85	0.70	-6.19	27	105	2012-10-10 15:06:27	2011-04-28 17:21:18	1	1	102	8	53	798	438	495.80	36	99.07	CHANGED	IPRsMuTQHPDNs.hP.a.s.psshlsu-DElpEAahsao.....thGs-EhMWDaEGK-sDpaVl+KLlopY.caFpcphLGcDlaLThRlPNPplEpsEtKlLsEshtsIspsaDhuchh.....t.sssPIFEVILPMTsssccl.plhchYcchlt.pt...h.s....htlcEhlG-h.PcpIcVIPLlEDtsuhlpscpIlpcYh....ctt..c.pahRVFLARSDPAhNYGhluAsLhsKhALpclhclpc-hulplaPIlGsGSsPFRGphsPtslpps.lpEYsGlhTaTlQSAF+YDashccVhculcplpp.tphppst.lsp-c...hhplhpphoppYppplcplAshlNplAphlPpRRpRKLHlGL.FGYuRsh.ssl..............................sLPRAIsFsuuLYSlGlPPELlGhusL...sc...cch......-hlpcsa.tltcDLphAscahN.-........ssthhhstctlhtlp-th-hhtp.............pcHp.hsppllpshppt.....................hcshllchuplRtFLG	.......................................................................................................................................IP+sMuTQHPDNsthP.a....s..psshIsup-ElpEAahuao.....tLGs-EhMWDaEGKcsDtaVlc+LhopahcaFppp.LG+DhFLThRlPNsphEcsp..pplhspshtslsps..hDhAchh......t.sttPlFEVILPMoposcplhp.l..t.chapchls..................hthc-..a.h.s.ch..sc.pIclIPLhEDhsuhLpsccIlccYh.........cph.......c..cYhR.......VFLARSDsAhsYGhluulLusKhALsclhchscchulpIaPIlGsGSsPFRG..s..L..o.P..cs..l.-ch....l....pE...Ys....G......lp.ThTlQ.....S....A...F......+...Y...D......a.....s.......h.....-.....c.....V.......p..p....A.....lpp....l.......ps......hph.....sps.....p.lscc-.....thhhclhp.phu.ppYppplcplssslspluphlPcRRcR+hHlGl.hGYSR.s.l.ssl..............................sLP..RAIsFTu......uhY.S.lG.l.P.PE.l.l....Ghu...pl..p..sc....cch......-hlhchYss..h..+cDlphAu+ahsh-............hsthhhspcshtcl...cEDlchhpp..hth........ppcH.sthsppllphhct.h....................hpphIhchAplR+hLG...........................................................................................................................................................................................................................................................................	0	17	31	43
+13853	PF14011	ESX-1_EspG		EspG family	Bateman A	agb	Jackhmmer:A5TZ16	Family	This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis.  These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread [2]. Proteins in this family are typically between 254 and 295 amino acids in length.	27.00	27.00	29.20	27.90	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.35	0.70	-5.12	66	505	2011-04-29 10:18:57	2011-04-29 11:18:57	1	2	116	0	134	371	0	245.10	22	90.72	CHANGED	Lossp......h.hLh-.thuhsp.hP................hsLsls..s.hss..tscRsshpppshs......pLp..ttGlhsst..plcsplsshlpsLscPshpl-sthhh.................sup....hRsh..............sutpss............psVlA..spss.......stlslpsht........ssuLssslsssLss...ss.Pup.hpslolPssphtpstp............t.tsst.htshlpphGl...sssssps.ltphhspspstsu.husptp.sst.......pspsssslshhD..Tsp.GRhlspsppu.ssp...W.solsPus.spplsptlppL	..........................hossshhhltp.hhshsp.hP................hsLslp....shhss........pspctthtcpshs..........pLs.thGllssp..t.....hsstltshlclLspP-hpltsthht................................ssp........hRsl.................lupcus............pt..VlA..hRsu.......shlslpsss.............................spsLsshlsssL....ss.............ss..PAs.hpslolstpphtcssp...........................s...ss.lpphul................ssssht...s.ltphhssspststhlusppc...sss..........ptpssssl.ulhD..oss.GRll.sts..p..puhsuc...a.hshsPuo.sttlttulpp.........................................................................	0	39	97	124
+13854	PF14012	DUF4229		Protein of unknown function (DUF4229)	Bateman A	agb	Jackhmmer:A5TZR1	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 122 amino acids in length.	27.00	27.00	27.60	31.20	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.33	0.72	-4.08	62	283	2011-04-29 10:23:44	2011-04-29 11:23:44	1	1	267	0	100	247	24	68.30	33	61.31	CHANGED	hlhYshsRLsLhsslssl...lh.hluhhhh.....shhluslhAllluhsLShhlhpphRpcsstsluth....sppR	.....hlhYshuRLhLhlslsul...lh.hl..uhhhsh......hsllluslhALllAhPLShhlFpslRccsotslAthscpR..........	0	29	76	95
+13855	PF14013	MT0933_antitox		MT0933-like antitoxin protein	Bateman A	agb	Jackhmmer:A5U0U8	Family	This family of proteins contains the MT0933 protein Swiss:O05901 which has been identified as an antitoxin to /protein MT0934 [1]. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 90 amino acids in length.	27.00	27.00	27.20	28.90	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.50	0.72	-3.86	58	385	2011-04-29 10:29:15	2011-04-29 11:29:15	1	4	326	0	102	249	0	55.50	39	74.87	CHANGED	lhD.............K..uKchlspp....t...........-plc....pGlDKAu-hlD..........cKTGGKYucplDpup-tAcctls	..................................hhD...........KAK-hlspp.....t...........Dpl-....pulDKAGchVD..........c+TsGKauDpIDpup-us+ctls.......	0	36	78	98
+13856	PF14014	DUF4230		Protein of unknown function (DUF4230)	Bateman A	agb	Jackhmmer:C7QH51	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 203 and 228 amino acids in length.	27.00	27.00	28.30	27.00	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.01	0.71	-4.36	170	626	2011-04-30 09:44:43	2011-04-30 10:44:43	1	1	536	0	162	520	25	157.40	18	73.09	CHANGED	lpplcslucLtshphphpplhshpsppphh.................h.hspp+hlhlhsu..plpsul.DLsclp.p..lph........pscp..................lplp.LPpsclh.ssp...lD...tp..hpha.sppps....hhst..........p.p.-hsphhppu.cpphtcpsh..pss.lhppAc...ppupphlptlhps....hth.......pphplph	....................................................................pplcplucLsshphthpcllshccsthhhh.....................hshsc+phhllhpuplph..sl.DL.pchs.t.lpl........sscp........................lplp.lPp.sclh..psp..lD....tp.....hcha..cppsu......hhs...............hs.p.-tsphhpcA...ccplpcpsh....pps..lhppAccsApsh...lpslhps....hsh.......pphph..................................	0	70	128	153
+13857	PF14015	DUF4231		Protein of unknown function (DUF4231)	Bateman A	agb	Jackhmmer:C7PX93	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 148 and 288 amino acids in length.	24.70	24.70	24.70	24.70	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.35	0.71	-4.08	76	408	2011-04-30 10:14:04	2011-04-30 11:14:04	1	3	361	0	94	240	33	109.30	30	56.78	CHANGED	.shhphhcpputpspptah.......hhphhpllh.hhuuh.....lsh....................h.......................tt.......shthhphsss..llus...hhshhsulhshh........phpcp....WhphRsssEtl+ppph....tah......................hpss.at..........ssppstphh	................................ss...lsaa.++usppR+cY+........lL+lspIlsuhLhAl.....IPh..................................................................sscphpllsl......sLSu...lshlspulhsla........sh+-s....WhsapcTAphLc+E+a..lYt.............sp.sp.Ys......sppc.....................................................................	0	23	60	84
+13858	PF14016	DUF4232		Protein of unknown function (DUF4232)	Bateman A	agb	Jackhmmer:C7PXZ8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 177 and 242 amino acids in length. Many members of this family are lipoproteins.	27.00	27.00	27.40	27.30	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.51	0.71	-4.49	69	475	2011-04-30 10:33:41	2011-04-30 11:33:41	1	4	262	0	148	421	0	132.80	20	63.79	CHANGED	CssssLshss.tssps..usGtp....hhhlslsNsuspsCsLpGa.Pu.Vshh.sssGs..............sssuscpss...........ssssVsLsPGpsAhAslthss..ssssss..........tssssss....ltl.tsP.ss........sssl.......tlshsss.........................................ssssplpVsshpss	...................Ctsstlphsh...s.ss...pu.......uhGtp..hhhLslp.N......suupsCtLsuh...Ps.lphh...sssGs.............hss..s..sttpss.............sspslsL.sPGpsstsslpats..ssssss..............shtstt...lhlh.s..st.........tsh.........l.h..h........................................................t...................................................	0	35	120	146
+13859	PF14017	DUF4233		Protein of unknown function (DUF4233)	Bateman A	agb	Jackhmmer:C7Q8C9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 122 and 147 amino acids in length. Proteins in this family are integral membrane proteins.	27.00	27.00	38.20	38.10	23.30	21.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.67	0.72	-4.12	61	349	2011-04-30 10:53:39	2011-04-30 11:53:39	1	1	349	0	92	219	71	105.30	33	79.73	CHANGED	Rs.lhAusLlhEulVlhLAhhVshplss.....h......sssshshssslslshllhsul.p+.sWulhlshsLQls.llsushlhPuhhhlGllFuhlWhhslhhtpclccchtct	....tVhAusLhhEsIVlhLAlPVhhtVuu..........h.........sshuhshssshsVlhllhush.tR.s.....WulhlshsLQlh.hlhushlhPsh.....hhlGllFuAlWhhlhaLt+clcpp.t.........	0	28	70	88
+13860	PF14018	DUF4234		Domain of unknown function (DUF4234)	Bateman A	agb	Jackhmmer:C7Q4E0	Family	This presumed integral membrane protein domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 70 amino acids in length.	23.70	23.70	24.00	23.70	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.76	0.72	-4.24	77	247	2011-04-30 12:47:06	2011-04-30 13:47:06	1	8	203	0	77	217	14	81.90	22	50.02	CHANGED	Rslshhll.Loll.......ThGIYslaWhhphsc-......................lsth..ssct..shshshhllls......................ll............................TsGlashaWha+hupcl.pthptp	............................hslhhhll.Loll.............ThGIYslaWhhphsc-.............................lsth...stct..thshhhhllhh.................................hl.............................................Thu..lh.lhWhaphuptl.t.....tt..................................................................................................	0	32	51	61
+13861	PF14019	DUF4235		Protein of unknown function (DUF4235)	Bateman A	agb	Jackhmmer:C7PYA5	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 88 and 119 amino acids in length.	27.00	27.00	29.10	27.00	25.70	26.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.60	0.72	-4.13	66	301	2011-05-01 09:52:26	2011-05-01 10:52:26	1	1	285	0	89	219	10	78.20	30	77.74	CHANGED	aKhluhusuhsuGhlAs+lhptlWcps..sG.ccsP...csp...............................D.ctuhtcslsaAslpGulhull+shssRuuApshp+hssp	..........aKshuhAlusluGhlupKlhptlW+hl...oG..ccsP....pss...............................D...-huhscsLsaAslSGsh..hAssphhscRtss+tat+hs..s...........	0	32	67	82
+13862	PF14020	DUF4236		Protein of unknown function (DUF4236)	Bateman A	agb	Jackhmmer:C7PYP4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 402 amino acids in length.	27.00	27.00	28.70	28.40	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.71	0.72	-3.85	88	345	2011-05-01 10:59:28	2011-05-01 11:59:28	1	20	326	0	69	260	50	54.00	41	22.01	CHANGED	a+FRKol+luPG.l+lNlSKsGl.ShS..lGs+.Ghplsh..stpG.htsosulPGTG..loYpp	........h+FRKSlplsPG.l+lNlSpuGs.ShS....lGs+..Gs.pl.oh...ss+G.thsslulPGTG..LSY+...........	0	24	47	65
+13863	PF14021	DUF4237		Protein of unknown function (DUF4237)	Bateman A	agb	Jackhmmer:C7PYW1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 123 and 781 amino acids in length.	27.00	27.00	27.80	28.30	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.20	0.72	-3.71	68	319	2011-05-01 11:03:08	2011-05-01 12:03:08	1	23	246	0	96	292	2	94.90	31	19.49	CHANGED	pssLssGp.hlDRaG............s.........stGsFluPt.....GssaspRuLP...Pssh..........spsY+hYc.......Vh+.....shs.l...................................htGslA..PWF.sQPG..GGsQ......a...................hh.....stslppLlppG.......hLccls	.......................p...l..Gs.hlDRaG............sstGpalush.....sssa..tpRuLs.sssh.............tpsY+hYp.......Vhc......sh...l..........................................................htG.lA..PaFuQPG..GGhQ.h.................ph................hslppLlcpG....hLcp..................................	0	27	56	81
+13864	PF14022	DUF4238		Protein of unknown function (DUF4238)	Bateman A	agb	Jackhmmer:C7Q0A2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 274 and 374 amino acids in length.	27.00	27.00	27.30	27.20	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.69	0.70	-5.12	94	367	2011-05-01 11:09:05	2011-05-01 12:09:05	1	5	301	0	117	350	7	261.60	15	77.69	CHANGED	+pHaVP..phaL+......pF............t................sppsplh.............................shph..................pppphhttshp.....shstcpphYshps.s.t.........................................................plEcth..spl.Es....phuphlpplhstpt..............lsspppp....tlhtFlshQhhRosthppphhphhpthhp.h........................................................t..t.........t.......tthttpthhhthhpphhp...........................htthhhphphtl....hhspssttFlTSDpPlsh...............................tt.sht.............pthplh......hP..loPchhlhh..........................................................................ttptttthhhhsp.pplp...plNph.hpp....up.......................chlaupspsththh	.........................................................................pHalPph.hL+ta..................t...................tppthlh..............................................................hhth...................tttthh..hs..hp...........phshtpthYp..t.......................................................................................lEchh..uhh.Es....phsphlp.tlhptht..............................................lstpptp.........tlh.palh........h.hhRs.sh....ttphhphhpt.hp.h..........................................................................................................t...tph....t.....................h..t..h..hh.p.th.p.............................................h...h.htphphtl.........stsppthlsSDs.......Plhh.............................t.s.....................phhplh....hPloPplhlhh............................................................................tt.p..hh....h...h..st.p....p....lp...........hNt...h.hpp...u.......................p.lh.tpt.....hh.......................................................................................................................................................................................................................................	0	45	75	102
+13865	PF14023	DUF4239		Protein of unknown function (DUF4239)	Bateman A	agb	Jackhmmer:Catenulispora acidiphila 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 254 and 270 amino acids in length.	21.40	21.40	21.50	21.40	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.31	0.70	-11.36	0.70	-4.97	9	249	2011-05-01 11:18:32	2011-05-01 12:18:32	1	4	178	0	136	268	20	198.00	18	72.03	CHANGED	lhsslullaushhuhslshLhppasclpcslssEAslLthlscslhsh.tsc.....cppspthltsYsctl..........lscshshh..pcs..phshh...shs.lsslhshlpthcssspsp.pshtpphl....spltcLpclRtpRlphtthuLsstaalllhhhoshshlsa........hshhsspthhthhuhhlhs.hsushhlFh.h......cLscPFpGsaplsps.shsphl	..................................................................................................h...hluslaullluhshsssh....p....phspsppsltpE....As.s.ltplhpt..s.t.s.h..s.ts...........psplcttlpsYsp.t...l..............lpp-Wsth................pps..ph.s.p.............ssphl..s..p.lhp....p.ltshps.p..sstp...tthhpthl.............splspl....hpsRppRlt.t..s.p.s.sls.s..shWhhllhhusl..h..h.lsh....................hh..hhht.pp..h...hp...h.hh.h...slhu..shluhhlhllh......ph.-pPatG.htls.t.......hh...............	0	41	82	111
+13866	PF14024	DUF4240		Protein of unknown function (DUF4240)	Bateman A	agb	Jackhmmer:C7Q711	Domain	This presumed domain is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 169 and 263 amino acids in length. This domain is often associated with the WGR domain Pfam:PF05406.	27.00	27.00	30.40	30.50	25.70	25.00	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.58	0.71	-4.29	59	244	2011-05-01 11:23:53	2011-05-01 12:23:53	1	6	205	0	77	229	6	128.60	31	61.94	CHANGED	Mscpc....FWpLlspsp........sss-tp.....thtchL....ps..........................tLsphssc-lhsFpphhpp...hhtc.uaphslW..uAAallpG............s.sSDDuFthFRsWLIupG+chacpsltsP..DsLuph....ptt............................................thEch.thlutcsacct	..................scpc....FWpLlcpuc...........tst-.-.......phtchL....pp...........................pLsphssc-llsFcphhpp...hhpc.u....Ys......sLW..uAAall.hG..............G..sSDDuFsa..FRsWLlupG+-sa-sslps.P..DsLsphht.h.pptt........................................sphE-l.halutcsYcp.t.........................	0	29	53	69
+13867	PF14025	DUF4241		Protein of unknown function (DUF4241)	Bateman A	agb	Jackhmmer:C7Q8Q9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 205 and 315 amino acids in length. There is a conserved GDG sequence motif at the C-terminus.	27.00	27.00	28.40	28.70	25.60	25.50	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.15	0.71	-4.51	46	192	2011-05-01 11:27:02	2011-05-01 12:27:02	1	5	160	0	42	186	6	172.60	31	66.89	CHANGED	plplsoGcllssDPL.............h.h..tstpP..ahpplssGpa.lplslsct.p..t............RhAss+l..................pascpc.....sspachAhhsspsl.ppl...c-u-.a......FGasVDAGhushsDhpstcthpcatpch.pcp.....hshY-DhFsphhpp...shtt.spapppss.shhsashssostslshFpSGaGDGh..YP....sYaGaDcsGplssllh	............lplsoGcllssDPL...............h...pspts....ahpplss.GpYslphtlspt.p..t............RhAss+l..................phscpc.....sstac..hAhhsspc...l.ppl...p-sc.a...FGasVDuGhushsDhpshpthpch.pch.pc.......hs.YsDhhs.phhpc...p..t.spappp..tG.thhs.h.hss...oshslshFpSGaGDGh..YP....sYaGhDpsGplssllh..............................	0	20	32	35
+13868	PF14026	DUF4242		Protein of unknown function (DUF4242)	Bateman A	agb	Jackhmmer:C7PZ36	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 90 and 170 amino acids in length. There is a single completely conserved residue C that may be functionally important.	27.00	27.00	27.40	27.10	26.40	26.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.47	0.72	-3.89	75	359	2011-05-01 11:30:12	2011-05-01 12:30:12	1	5	329	0	110	241	112	76.80	43	51.89	CHANGED	pallERc.....lPss..los-pltshpppssshhsch....ssVpWlcSaVs.tps...+.saClYpAPst-ul+ctsccu.GhPscpIscV	...cYLVpas.....IPcu....ITh-phhAp.++KsssthcEl....P-VcFhRoYVsEDhu....K.shCLYsAPDEEAVRRA++ts.stPlDsIp..h..	0	40	81	98
+13869	PF14027	DUF4243		Protein of unknown function (DUF4243)	Bateman A	agb	Jackhmmer:C7QAE2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 348 and 477 amino acids in length.	27.00	27.00	29.30	29.10	20.00	21.20	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.12	0.70	-4.99	118	340	2011-05-01 11:33:20	2011-05-01 12:33:20	1	10	167	0	246	351	4	303.70	23	73.39	CHANGED	tha............N...HhsHtlhulatLGAsssp....lppha...........-pptphhp.h............stphhs......psa....cphLG...cpchhtsalsFFpcElp...........pcG...hcpVlpcYha............ttpt................................h.pllstlhuGhhHPlI+LGaulEhs.pst......................llAEu..................LA.sAsch..s.h.thh..ss....ttts................................................................s.shh...pllpc.lpsstphps....ss.....................ht.thlh..cthcphh.hs...............................u.hh..........pphpcpht-hhpss....shhhsust................t..phDF.....hhlHslTuuhhlphll.hh......sspp+hpllc...hhhthslshYsupupPph.....hpplhphhs.t................................sWpplhpp.hsttps...Ds...HhsKhlRuhtp	..................................hpN...HhsHtlhuhathGAsspp....lppha...........-tttph.csh...................s.p.hst.....psa..........pphLG.................ctchhtsalsFFpcclt................ppG....hptVlpcala...............ttpt..................................phlstlhuGhhHPlI+LGaulEhp..p.t..........................lhuEu..................LA.sAsp....s.htthh..ss......t.t..........................................................................stshh...pllpp.ltt.s.tchps.....sh.....................ht.shlh......pt.cphh.ht......................................u.hhh...............pphpcpht-hh.pss.......................shhhssst................t..thDF.....hhlHhlTuuhhlthl..l..shh.......s.p.+hpllchhhh..hslshYhupspPph.t.ptl.h.s..h.st..t............................................sWptlhpp...sh.ts........Ds........HhhKhhRshh...........................................................................	0	71	141	213
+13870	PF14028	SpaB_C		SpaB C-terminal domain	Bateman A	agb	Jackhmmer:C7QBX6	Domain	This presumed domain is found at the C-terminus of the SpaB protein Swiss:P39774. SpaB is involved in the synthesis of the lantibiotic subtilin.\	\	\	\	  This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 317 and 1029 amino acids in length. The family is often found in association with Pfam:PF04737, Pfam:PF04738. This domain is found in isolation in some proteins. This domain is also found in EpiB involved in epidermin biosynthesis.	27.00	27.00	27.60	29.10	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	283	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-12.08	0.70	-4.85	142	404	2011-05-01 11:47:07	2011-05-01 12:47:07	1	9	270	0	119	365	3	254.40	19	35.28	CHANGED	W.hth+l..hsts.pt...-phlsptlsshlsph.....tts..hpt..aFFlRYtc.....st.....HlRLRl...pss..p.......thhtthhs.....tltphht.....hhtt.............................thhsphphss..YpPEht.....RYGG.ssshshAE...plFttDSthsls..hlt.............tthshph...................................................phlsuhshhp...............hhs.h.....................p..pt..........................................................hphhtchspptttt.ph.hps.tt....thhpltp.....hthht...s...t.th..........hhppttpthsthtphh.....................................................p.t.p..htsllssh.....lHhphNR..hGls.tppE...thlhph	........................W.hhh+l..atst.tt...-phlhctlhshlcph........tps..lsp..aFFlRYhc..................s...sHlRLRl.....phss.t...........htthht..............tlpphhp....thhpp.........................................shhsshphss..Yc.Eht.....RYGG..sshshuE....phFphDSthslp..hlp...............shphph......................hlsuhshhh.........hhp..hsh.......................s.ppt.................hphhpp.hhspth..tp......t.hpthht................thhplhp........ht.ht...t..th..h............hhpptpphhsphpphh.....................................................ttt.tpt.hpp....llsSh.....lHhptNR..hGls..hppEthhh.....................................................................	0	51	92	110
+13871	PF14029	DUF4244		Protein of unknown function (DUF4244)	Bateman A	agb	Jackhmmer:Catenulispora acidiphila 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 66 and 95 amino acids in length. There is a conserved EYA sequence motif.	27.00	27.00	27.20	28.00	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.61	0.72	-4.87	53	401	2011-05-01 11:52:36	2011-05-01 12:52:36	1	1	400	0	101	287	10	54.10	44	67.72	CHANGED	tttpthtsttss-pGMuTAEYAluslAAsAFAulLhhllpSssVpshLpullppALs	.........hh....hhhhh.s-pGMuTAEYAlGslAAsAFAulLhtVlTussVhotLpsllspALp....	0	30	74	94
+13872	PF14030	DUF4245		Protein of unknown function (DUF4245)	Bateman A	agb	Jackhmmer:C7QKK2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 188 and 235 amino acids in length.	27.00	27.00	56.40	56.30	26.20	24.50	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.93	0.71	-4.52	59	339	2011-05-01 11:55:11	2011-05-01 12:55:11	1	1	335	0	84	236	22	175.20	31	88.33	CHANGED	Rhhp....ss+DMllSLsllllsshll.hhh........stsss.ss.lssVDssstlptsuc..ss.saPlttPp...lPcGWpssSu..chsshsu............ssshplGalTss......spYlplsQossssss.......hlsthssst.ps....sGspsluGp.sWphaput.........sscsshVtc.h....sssp......lllo.....GsAstc-hcslAsAlt	.........................t.ss+DMllSLuslllsshll.hhh....................stssc..pssl.pV.D.hpssltsstp..sh.uaPlttPp.......lPc...s.WpssSu..chsshss............uss.plGalosp......stYlulsQSsts.tct.......hVuu.lstuspp.........sGshsV.u...Gh...pWshasus-........stppshVsc.l...........Gss.pllls.....GsushcphpshAusl..............	0	26	62	80
+13873	PF14031	D-ser_dehydrat		Putative serine dehydratase domain	Bateman A	agb	Jackhmmer:A5U2B6	Domain	This domain is found at the C-terminus of yeast D-serine dehydratase [1]. Structures have been solved for two bacterial members of this family. The yeast protein has been shown to be a zinc dependant enzyme.	22.00	22.00	22.90	22.90	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.02	0.72	-3.79	98	1102	2011-05-01 13:05:54	2011-05-01 14:05:54	1	7	847	7	478	1062	313	98.80	27	25.73	CHANGED	AlhlhupVlStsp.......spsllcsGt+uluhDs..........u.....h..................th...sh..shs..................t..s..............................shphsth.u...-EHuhL........................p..h..........sss......ss.....................h........plG-hltlhssHsCsThshachhhlVc	..............ALpVhupVlSpsps......spsllDsGp+sluhDt.............u..h......st...............sh.uh.lhs..................ts..............................sh..plssh.s...-EHuhl................................p.h........sss..........st.....................l.......plG-hlplhPsHsCsTsshacthhll........................	0	134	278	399
+13874	PF14032	PknH_C		PknH-like extracellular domain	Bateman A	agb	Jackhmmer:A5U8Q1	Domain	This domain is functionally uncharacterised. It is found as the periplasmic domain of the bacterial protein kinase PknH [1]. The domain is also found in isolation in numerous proteins, for example the lipoproteins lpqQ, lprH, lppH and lpqA from M. tuberculosis. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 268 amino acids in length. There are two completely conserved C residues that are likely to form a disulphide bond.  A second pair of cysteines are less well conserved probably form a second disulphide bond. It seems likely that this domain functions to bind some as yet unknown ligand.	27.00	27.00	27.20	28.50	25.50	26.90	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-11.25	0.71	-4.73	68	678	2011-05-01 13:51:53	2011-05-01 14:51:53	1	4	94	0	115	462	0	188.20	19	66.25	CHANGED	sslsssslsslL.....Lsss-l....ssl.hGssthtsstsssshs.............sspsssspChushsssps.sYt........shs..sh+stsh.........tssssssth.lpQulssassspsApphh..sshssphpsCsstshsht...........tts.sttaplusssssss...hlshshsttsst.......hsCt..+shsspsNlll-lpsC...........sssssst...usplssthhs+l	........................................................h.sh.sstlsslL.....Lstucl....ssl.hG.ss.th.hs.th.stsht................sssssss.pCtsshshsts.sa.....shs...uhputsh..........t.s..ss.s...tsph..lsQuVssa.sssssAcpha..pshssphppC.sGpshshh.......................tsststthsluss.sssss....slshshtttss..................hpCt.....+shtlcsNVll-lssC...........ttspssss...usslssthhspl....................................................	0	27	69	99
+13875	PF14033	DUF4246		Protein of unknown function (DUF4246)	Bateman A	agb	Jackhmmer:Q59QG7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and fungi. Proteins in this family are typically between 392 and 644 amino acids in length.	27.00	27.00	31.80	27.70	23.20	25.30	hmmbuild  -o /dev/null HMM SEED	503	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.81	0.70	-5.89	50	374	2011-05-02 10:30:38	2011-05-02 11:30:38	1	6	93	0	324	394	5	341.20	30	77.80	CHANGED	tsshts.hhTlREhsMlplMsplTDKPsWcpKlaDc.sIs.s+W+p...Eslspsp.................................................tlocphh-aslpELcaK....Aphac.cs..Gh.l.s..hss...........sVsKS..Dosls...ssLpppL+sul.phLcss....tsp.D.aHPuosppVlDLVHPSLFPLVYGRT+.llssth..lsl-..ssltt..GpGpllPh...sspppt...................h......ttht.hhaSp+FQWLPspVch.....................ssssss+IsSYINNLHPt+a+sLYpsIEpllspsIPhWNpsLs.h......................tsct.hRIph.ts..........................................p.pp.p.tps--.pch.cchp............pW.ppppphl.......................................P-P.ttFp......................................................sp.pttlsL.pccFp..ppGLQVIVKlAsIELTPEc.PpYsGG.sWHVEGph...............NEHIsATAlYYYDs-NITpS.pLuFRpts..-sp.......p.t...a-pss...........................p.palpplaGhcst...........ssshQplGuV.psppGRLlsFPNsl.................QH+VsPFcLtD+oKPGHR+hLsLaLVDPphR.IlSTANVPPQpp-WWs-tst	.........................................................................................................h...........................................................................................................................................................................................................................................h.....p...............h.........................................................................hh.h..t................................................................................................................hs.thphLPs.hth.......................t.thph.S.YlNNL.p..P.......h.Y...hltphhtt.ls.hp.hh................................................hh...........................................................................................................................................................................................................................................................................................h........................................................................hpl........t..tptlpl......IV+hssIpLT......Pp.p.P.p..a............ts......t.........WHhEG.h......................NEpIsuoslahhs..pN.lsts..pltFR..h.................................t........................................htpl.asht.t.............t.h.Q.lGsl..h....p....G........RhlsaPNhh.................QH+.psFpLhD.opP..GHp+hLshalVsP.....t..hc...l.hSTspVsPQp.pWh.p..h.........................................................	0	160	218	286
+13876	PF14034	Spore_YtrH		Sporulation protein YtrH	Bateman A, Eberhardt R	re3	Jackhmmer:C0H3P8	Family	This family of proteins is involved in sporulation. It may contribute to the formation and stability of the thick peptidoglycan layer between the two membranes of the spore, known as the cortex [1]. In Bacillus subtilis its expression is regulated by sigma-E [2].	27.00	27.00	77.80	76.70	19.50	19.00	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.19	0.72	-4.09	29	206	2011-05-04 11:44:28	2011-05-04 12:44:28	1	1	206	0	47	114	0	102.90	53	87.53	CHANGED	hsshlhsFFlAhGVllGGullGGlGAhLsscPPLpshhpLAspLKIWAllAAlGGTF-slpslEpGlhpGphcslhKQllhIluAhhGApsGhhlIpalstsp	.hs.hlIlSYFIAFGVlLGGSLIGGhGAaLhG+PsLT........h........hsphApsL+IWALVAAIGGTFDoFYuhERuhFtG-h+DIlKQlLLIhhAhGGhQTGhlII+WLTQE....	0	20	36	39
+13877	PF14035	YlzJ		YlzJ-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:C0H413	Family	The YlzJ-like protein family includes the B. subtilis YlzJ protein Swiss:C0H413, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 61 and 72 amino acids in length. There are two completely conserved residues (L and G) that may be functionally important.	27.00	27.00	36.10	36.10	19.90	19.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-9.15	0.72	-3.92	39	213	2011-05-04 11:51:42	2011-05-04 12:51:42	1	1	213	\N	58	134	0	64.20	40	93.42	CHANGED	LYTlhP.Ehla...ttpcsthpspp...plphs.Gl.llVcthps..sp.....hcllRllSTsPhcYLpschsPGshlp	.............LYThMPpplVa...sss..sps.pspc....Vsls.GVpLhVpp.cp..sp.....YpIVRlLS.TsPhcYLc.tapPGppIp....	0	27	44	49
+13878	PF14036	YlaH		YlaH-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O07632	Family	The YlaH-like protein family includes the B. subtilis YlaH protein Swiss:O07632, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length. There is a conserved LGFA sequence motif.	27.00	27.00	61.50	61.20	22.70	22.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.67	0.72	-3.90	23	162	2011-05-04 11:58:59	2011-05-04 12:58:59	1	1	162	0	30	97	0	77.20	63	74.91	CHANGED	scssthGhallYlsIllLullVapLGFA+...KLPlLKslllYllLhlGshlLTFhulh..LPlsEuLlVAAllLhIY+lRL	...D.ENPElGMWLLYGsIllLSAlVYNLGFAR...KLslLKNlVIYl.LAlGCTVLTF.FAVF...LPVGEGLVVAAlVLuIYRlRL.	0	9	21	24
+13879	PF14037	YoqO		YoqO-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O31923	Family	The YoqO-like protein family includes the B. subtilis YoqO protein Swiss:O31923, which is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 120 amino acids in length. There are two completely conserved residues (I and Y) that may be functionally important.	27.00	27.00	39.90	39.80	22.90	20.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.60	0.71	-3.98	8	164	2011-05-04 12:01:38	2011-05-04 13:01:38	1	1	97	0	11	108	1	108.70	49	88.71	CHANGED	p+pIGaYGllhshhlSlllptFhps-hlsh.IlssssFlFlllYsWD-hKsYS+KslllhuIpFlIlluslsFlLhcGpchh-slslFpGWlhlA+llYllhlLslsssIh++Isc+L	..RcKIGaaGhllsh.L.lI.s.FhpsEWls..IlslhshlFs.hYpWD-hKtYS+Kphhlh.hphVlh..hlsFlLlcGpc.h-thshFQtWh..AKhLYllhllhlhhh..lshplsphl.......	0	2	5	6
+13880	PF14038	YqzE		YqzE-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O32020	Family	The YqzE-like protein family includes the B. subtilis YqzE protein Swiss:O32020, which is functionally uncharacterised. It is a part of the ComG operon, which is regulated by the competence transcription factor ComK [1].  This family of proteins is found in bacteria. Proteins in this family are typically between 49 and 66 amino acids in length.	27.00	27.00	29.40	50.40	23.00	22.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.22	0.72	-8.76	0.72	-4.22	19	154	2011-05-04 12:12:15	2011-05-04 13:12:15	1	1	154	0	26	79	0	49.50	58	82.40	CHANGED	psNDYVKahTpphVpYhDpPK-ERKcc....+ptRKppK.Ph.t.RWFGllPhuhpLha	...ssDhV+ahTpphVpYMDsPKE-RKp+....KEpR+s.EKEPF.hs+WFGlhPLShsLaa...........	0	6	16	18
+13881	PF14039	YusW		YusW-like protein	Bateman A, Eberhardt R	re3	Jackhmmer:O32189	Family	The YusW-like protein family includes the B. subtilis YusW protein Swiss:O32189, which is functionally uncharacterised. This family of proteins is found in bacteria, and is approximately 90 amino acids in length.	27.00	27.00	29.40	29.10	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-10.10	0.72	-3.71	19	189	2011-05-04 12:17:32	2011-05-04 13:17:32	1	1	183	0	23	103	0	91.80	45	49.90	CHANGED	hppF-L-l-ap-s..pph-hpYE..ccpsph-Aclc...cthss.phpG-EAhpclcsll.spLslsssssppcllspVlssFsL-p.shpch-l..........ElpFpD	.asEF-L-s-Yp-s..p-YEssYc.ltuspphEAclE.....DcpADlcLpG-EAhsKlpsLL.pcLphcpsTs-...p-Vl-pVlssFpLDc.cYp+F-L..........ElsFoD.	0	9	18	19
+13882	PF14040	DNase_NucA_NucB		Deoxyribonuclease NucA/NucB	Bateman A, Eberhardt R	re3	Jackhmmer:P12667	Family	Members of this family act as deoxyribonucleases [1].	27.00	27.00	27.20	27.00	25.40	26.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.77	0.71	-3.93	29	243	2011-05-04 12:23:46	2011-05-04 13:23:46	1	15	181	0	66	192	1	103.50	50	43.24	CHANGED	lpasss+YP...ETupHIp-.........AltsG..................cucls.TIDRs..uAcppRcpSL+..........shPs+.........pGhDRDEaPhAhscEGGsG....Asl+hIsPoDNRGAGS.lu......................p.QLusas......DGs+lhhhl	............................................................................tFPppRYP...ETupHIpD.....AIp.p.G..................HS.clC..TIDRs.........GAscRRc.SLt..........shPoK.................pGYDRDEWPMAMC..cEGGpG...........Aplc.....YI...oP..uDNRGAGSWVG.......................ppLspaP.......DGT+VhF.l.........................................................	0	12	39	49
+13883	PF14041	Lipoprotein_21		LppP/LprE lipoprotein	Bateman A, Eberhardt R	re3	Jackhmmer:A5U518	Family	The family includes putative lipoproteins LppP and LprE from species of Mycobacterium. LppP is required for optimal growth of M. tuberculosis [1].	25.00	25.00	25.50	25.40	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.96	0.72	-9.79	0.72	-4.05	49	283	2011-05-04 12:39:40	2011-05-04 13:39:40	1	6	143	0	72	185	0	87.80	29	41.83	CHANGED	sssYsss..........upLShlhlp.hssssssss.........ppshhFcpGcalGososcsh......shlssh.tssssslslpYph.t.s-ssssso.GtssVpF+W........ssspl	............................................s.ssasts.......spLShVhlp.sss.uss.sss.........ppslhFHpGpalGouoscsh.......shlssh..tsosDoVslpYp............sp.....t.....sssu.h....hssVpF+W.ssst.h.....................................	0	13	45	68
+13884	PF14042	DUF4247		Domain of unknown function (DUF4247)	Bateman A, Eberhardt R	re3	Jackhmmer:A5U5U9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 143 and 271 amino acids in length.	27.00	27.00	41.80	41.50	26.20	25.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.99	0.71	-4.17	29	214	2011-05-04 13:10:41	2011-05-04 14:10:41	1	1	211	0	35	139	0	171.20	35	83.97	CHANGED	huslhl........shuss............t.sspsaluspYsptus........s..thhhssstosspVAsplsst..ppPssps......s-............................ssshaLRYs....DclVtl.............................................tscstss.................................hIcV-shc.............................................suYpphs.........hhhhus....thssssP....sGusstuu..........GssGuu	..........hhlssAs.....hhluust............ts.sp.Its+YshESss.........ps...hshhssspSsspVAccLlst..pcPpptu..p-................................psphaLhYs....Dc.Ihsl.............................................p.Dtppsss...............................lIclpNhc.............................................usYpshs.........................................h.t..............thTPss.....pGu.hcpu..........GssGu.h............................................................	0	11	21	28
+13885	PF14043	WVELL		WVELL protein	Bateman A, Eberhardt R	re3	Jackhmmer:O31578	Family	This family includes the B. subtilis YfjH protein Swiss:O31578, which is functionally uncharacterised.  This is not a homologue of E. coli YfjH, a synonym for IscX, which belongs to Pfam:PF04384.  This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length and contain a highly conserved WVELL motif.	27.00	27.00	103.30	103.20	20.40	18.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.51	0.72	-4.35	16	169	2011-05-04 13:47:27	2011-05-04 14:47:27	1	1	169	0	20	74	0	74.40	61	86.64	CHANGED	p-hhE+LTspLLEKNspLSYspARTWVELLWpDFEoThAKAG+tYpGp-hTEclVppWI-pYGupLHpapsppsK	.N-haEpLTpELL-KNc+LSYuQARsWVELLWpDFpoTYAKuG+.YQG-EMTEplVRpWIpsHGu+LHchcosNPK.	0	6	12	15
+13886	PF14044	NETI		NETI protein	Bateman A, Eberhardt R	re3	Jackhmmer:O34700	Family	This family includes the B. subtilis YebG protein Swiss:O34700, which is functionally uncharacterised. This is not a homologue of E. coli YebG, which belongs to Pfam:PF07130. This family of proteins is found in bacteria.  Proteins in this family are typically between 42 and 66 amino acids in length and contain a conserved NETI motif.	27.00	27.00	27.00	43.80	22.60	19.70	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.76	0.72	-4.46	23	336	2011-05-04 13:56:26	2011-05-04 14:56:26	1	1	336	0	28	97	0	51.50	63	91.60	CHANGED	KFcVpENETIu-CLsRMcpEGYhPlRRhEKPlFcEsKcs...plpsh+QcIlF-GKh	.KFcVpEsETIsDCLsRMK.pGYMPV+RhEKPlFpEpK-G...sVEss+QcIlFhGKh.	0	7	15	23
+13887	PF14045	YIEGIA		YIEGIA protein	Bateman A, Eberhardt R	re3	Jackhmmer:P50742	Family	This family includes the B. subtilis YphB protein Swiss:P50742, which is functionally uncharacterised. Its expression is regulated by the sporulation transcription factor sigma-F, however it is not essential for sporulation or germination [1]. This is not a homologue of E. coli YphB, which belongs to Pfam:PF01263.\	   This family of proteins is found in bacteria. Proteins in this family are typically between 276 and 300 amino acids in length and contain a conserved YIEGIA motif.	27.00	27.00	87.60	87.40	18.70	18.10	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.58	0.70	-5.78	25	191	2011-05-04 14:04:51	2011-05-04 15:04:51	1	1	173	0	39	117	0	277.00	56	96.04	CHANGED	hhsllhGllhGslsRlhhL+sDYRQYPTYPHGhlIHluLGhIAAuLGAlAlPALlcc-aTAlTFLuLAApQFR-VRsMERpTLspL-shELVsRGssYIEGIApsFEuRNYlslhTuhlTohshh.hh.........slhhGslsGllshlls+plhpGpplsDIA-lchuclpF.-GstLaV-cIh.IMN.lGLppp+EhlLccGhGhllpPKshs..utsTlsNlGQRQAIlH-lushLGlh+DsspPshsPlu++Dl-sGclulhllP.cpDh-thlcllcplPlLEoAh+hPpctc	......sllhGllhGhhsRlhMLRTDhRQYPTh.HG+lIHIuhGlIAAALGAIAlPulLcK-FoAITFLTLAAoQFRDVRNMERNTLppLDuYELVPRGsTYIEGIAllFESRNYLuhlTSFsTThAYlhFt.........ShlAGlIhulIuhaIu+pLMSGcpL+DlsDIEal.l+F...-GuGLYlDNIY.IMN.IGLPs+QEcIhKaGMGFIL+PKshD..AhlTIuNLGQRQAILHDVSssLGlYRDSGTPuLVPLAKRDL-..DGRVGIFlLPQ-pDsEKAItVItNVPsLESAl+MsoE..t......	0	21	30	34
+13888	PF14046	NR_Repeat		Nuclear receptor repeat	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	This is a repeat domain involved in dimerisation of nuclear receptors proteins and in transcriptional regulation in general. It contains a  Leu-Xaa-Xaa-Leu-Leu motif which has been characterized for the orphan  nuclear receptor Dax-1, which represses the constitutively expressed  protein Ad4BP/SF-1. The LXXLL motif plays in important role in binding of Dax-1 to Ad4BP/SF-1 [1]. The domain is subject to structure\	determination by the Joint Center of Structural Genomics.	27.00	20.00	28.30	25.80	23.40	19.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-8.23	0.72	-4.23	14	140	2011-05-04 15:59:12	2011-05-04 16:59:12	1	6	28	0	57	131	0	47.60	54	39.46	CHANGED	FCGEDHPpQGSILYsh.sSAKQTpAA...PEsp.GushWssSCGup+sl	....FCGEDHPpQGSILYshLTSAKQTpuAs.....pAPEAR.GushWssSsGup.s...............	0	4	4	9
+13889	PF14047	DCR		Dppa2/4 conserved region	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	This domain has been characterized in the finding of a developmental pluripotency associated gene (Dppa) in the lower vertebrate Xenopus laevis [1]. Previous to this discovery, Dppa genes were known only in higher vertebrates. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	27.00	29.20	27.10	25.60	20.20	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.46	0.72	-3.69	8	100	2011-05-04 16:17:40	2011-05-04 17:17:40	1	4	27	0	57	74	1	66.80	62	23.52	CHANGED	GhhWCVVHGp..sssscuWltLph.HuGpsaVPsc..G+sIsLFLLPushhPPstlcDNhLCscCV++Nc	.......GsRWCVVHG+sLPADocG.WV+LQF.HAGQAWVP-p..tRhhuLFLLPA........CsFPsPtLEDNMLCPcCl+RNK....	0	4	4	6
+13890	PF14048	MBD_C		C-terminal domain of methyl-CpG binding protein 2 and 3	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	CpG-methylation is a frequently occurring epigenetic modification of vertebrate genomes resulting in transcriptional repression. This domain was found at the C-terminus of the methyl-CpG-binding domain (MBD) containing proteins MBD2 [1] and MBD3 [2], the latter was shown to not bind directly to methyl-CpG DNA but rather interact with components of the NuRD/Mi2 complex [3], an abundant deacetylase complex. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	27.00	29.70	28.40	20.90	19.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.12	0.72	-3.40	26	237	2011-05-04 16:22:55	2011-05-04 17:22:55	1	4	92	1	125	236	0	93.50	48	36.94	CHANGED	cs.ssE.llpsh-LscsLpslu.PshsscsLlpulAouL+hsus.....PlsGQssutptl-psPus...hhsssQPLCpthl.....VT-..-DI+cQEc+VppARcRLp-AL	.....................................................t..stE.llcoh-LPKuLps....VG.PGss--.TL.LpulAoALHoost.....PlTGQhou...AlEKNPuV........aLNssQPLC+....uFh.....VT-..EDIR..+QE-+VppsR+RLpEAL....	0	28	36	66
+13891	PF14049	Dppa2_A		Dppa2/4 conserved region in higher vertebrates	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homologue in Xenopus laevis [1], reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	5.00	27.70	14.90	26.00	4.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.94	0.72	-4.14	2	81	2011-05-04 16:24:09	2011-05-04 17:24:09	1	3	20	0	43	57	0	69.70	47	25.78	CHANGED	ppQshPEhS.Es+LQpCSRKtKhVsK+A+L.+ShchpERtEEoNTVEVlTSA.tuMLAuWuRIAARAsQsKulNSpSIPsSVEsFL	.............hst...Es+.......tK......................p........EcsNsVcVhTSA.EAhLASWARIAARAspPcAVsS..........................	0	2	2	2
+13892	PF14050	Nudc_N		N-terminal conserved domain of Nudc.	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics.  NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger [1].	27.00	27.00	28.00	27.30	26.40	25.50	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.06	0.72	-4.02	60	308	2011-05-04 16:54:57	2011-05-04 17:54:57	1	5	149	0	172	299	1	55.90	41	17.99	CHANGED	p+aDshLhslAppp.sulpshL-shFuFLpRKTDFap.............................G.hp.spsccllhcsFc+	......paDshLLslhQpp.uslpp....hLsshFuFLtRKTDFap..........................................G.hs.GhAEcllhpsFp........................................................	0	66	83	132
+13893	PF14051	Requiem_N		N-terminal domain of DPF2/REQ.	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	This putative domain has been detected on the human DPF2 protein and was subsequently targeted for structure determination by the Joint Center for Structural Genomics (JCSG). Possibly, the C-terminus extends by 30 amino acids and forms a separate domain. DPF2 interacts with estrogen related receptor alpha (Err-alpha), an orphan receptor which acts as a regulator in energy metabolism [1].  It was also identified as an adaptor molecule that links nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa-B) dimer RelB/p52 and switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling factor [2].	22.00	22.00	22.10	22.10	21.20	21.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.34	0.72	-4.05	13	277	2011-05-04 16:55:41	2011-05-04 17:55:41	1	6	85	0	123	214	0	71.30	70	19.10	CHANGED	lsDshY+EslEsussaNoRLshER..RlRhPFLDsQTGVAQscs.tlahppcpRhPGpstGQlYTYPu+RWRK++Rp	.......L.G-paY+-AlEpC+sYNuRLCAER..SlRLPFLDSQTGVAQsNC.YIWMEK+HRGP..G..l.....AsGQlYTYPARpWRKKRR.....	0	24	34	74
+13894	PF14052	Caps_assemb_Wzi		Capsule assembly protein Wzi	Eberhardt R	re3	Jackhmmer:A7UZC7	Family	Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation [1]. This family plays a role in group 1 capsule biosynthesis. It is likely to be involved in the later stages of capsule assembly. It is likely to consist of a beta-barrel structure [2].	27.00	27.00	27.20	27.20	26.80	26.30	hmmbuild  -o /dev/null HMM SEED	443	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.44	0.70	-5.63	92	390	2011-05-05 12:32:33	2011-05-05 13:32:33	1	2	294	0	143	386	206	444.60	21	90.03	CHANGED	lphhsphGshtus.hsphPhhhpusptslspspsss..................shlpttltpthp.........ttttphp.......................................................................................huhslcs.hshst....ss........................................shplppuYlshphtshtlssGppcph...Gh.......sGuhhhosNARPlPtlplspsp.hsh.s.hhphhhshphphthGhh...ps........s...........chstps..........hhautphhh+.t..p........pLElGlshsstaGGp..............Gp.ss.....uhpsah..cshhutt.t.....st..........s.GNpluuhDh+hph..hhphshtlYtphhhEDpuuhh.h........................tshlhGlchph......hspsphh..lhhEahpTp.pss...................ssaYspshY.sG.apahGpslGssh...........................ssc..spshplGhptp.......hssphshphphsasct.ssh.t........................h.....phtthhcl.....h....hthhst....h....phsushuhcps..phh.ssshshtlslph	................................................................................................................................................................................................................thhsphGshths.hsphPl.hpthtpsLppscss.......................hstlpttlptthss..................thtths...................t................................................h......................................ht............ashtlps..shpts................................................................t.tchpl.p...puYsshp.....hts.h.hlshGphppahGPGh..........sGullh..osNARPhstlplp.psp..hsh.s.hhph.lsshphphshu..ph........ssp.....................phsscs...................hhhut+h.sh..pPh..p........pLElGhsp.sh..paGGc...................Gc.sp.....uh.psah..cshh....upsss.t........t.s....................p.GNpluu...aDh+hph........h.hsh.....slulYtphhtED.......pu..uh.h.t......t......................pshLhGlc.hph.......sppsh....lhhEahsTpspss......tt.................shhYs.H....th.YtsG.atppGhslGssh........................................................sscupshtluhphp.......hssp.p...hpsphpaschsss.t......................sh...pppp.thlpl....tat........hhtth.plpsshhh..sps..p...sss.sh.hth.................................................................................................	0	48	102	127
+13895	PF14053	DUF4248		Domain of unknown function (DUF4248)	Eberhardt R	re3	Jackhmmer:A7V2Q3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 73 and 86 amino acids in length.	27.00	27.00	28.60	28.50	26.90	23.20	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.01	0.72	-4.39	64	339	2011-05-05 12:42:11	2011-05-05 13:42:11	1	1	64	0	17	200	0	68.30	36	86.02	CHANGED	ahlRs.Ys+sELAhhYhP.....sl.ss.puAhc+LpcWIcts.tLhppLttsGYpppp+haTPtQVplIlcaLGEP	.......a.l+s.Ys+sELA.thYhP.....sl.sspsAhc+Lp+WIcts.sLhppLtssGYpsps.+t.aTPtQVplIschLGEP....	0	8	15	17
+13896	PF14054	DUF4249		Domain of unknown function (DUF4249)	Eberhardt R	re3	Jackhmmer:A7V6V4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 279 and 365 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	27.00	27.00	27.20	28.20	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.95	0.70	-5.06	80	352	2011-05-05 13:08:51	2011-05-05 14:08:51	1	2	162	0	154	373	218	287.50	17	90.65	CHANGED	hhhllhhhhh..suC...pc.l-l.shsss.s+LVlsuhls......sssssttlpLoposshhssp..........lssApVpl.......sssptpshhhtpsss........................shYh....sss..........hspsGcsYpLplph..stpphsApsplstss.sl.pslphpptshhsspp.pp.....................lplpapDss.sppNYYhhphp.pph.hh.........................................................................................tlhsDphh.........sGpphshthhhp..............................phpsssplplplhulocshYpYhpsl.ptpsss.....ss.hhstPsslhuNlhsu...................lGhFussphs.phphpl	............................hhhhhhhhh.suC...pc.l.s.h.p....hsss...spLVlpuhls................ssssthlpLopo.....tsh..hsst..........................lssApVpl............................hssptpphhhtpsst.................................stYh...........sssh.................thpsGcsYpLpl.....ph..st....pph.sA.p.s.p.lstss...tl..pslp..hp...thhs.tt.t......................hplshpDss...spp...sYY...hhp.hp.pth.h...............................................................................................t.h.........................lhsDp.hh..............sspp.hp.hth..t..............................thphtt.pl..tlchhulocphYpYhpsl.thpsss.........................st.h..stPspl...uNlpss......................lGhhsssshs.ph.h..h........................................................................	0	77	140	154
+13897	PF14055	NVEALA		NVEALA protein	Eberhardt R	re3	Jackhmmer:A7V7L0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 75 and 92 amino acids in length. There is a conserved NVEALA sequence motif.	27.00	27.00	27.10	27.20	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.46	0.72	-4.27	65	219	2011-05-05 13:17:48	2011-05-05 14:17:48	1	1	44	0	36	174	0	71.20	26	84.01	CHANGED	K.....p..Klhhhhhhusl.sshsGashhps...pptc.....thS.DLuLsNVEALA.sGEss..............s...............................stsshsC	..............phhhhhhh.uhl....sshsuhshhps....pptc.....ph.S..-LsLsNVEALA...suEss..................................ss................h..C....................h...............................................	0	6	19	36
+13898	PF14056	DUF4250		Domain of unknown function (DUF4250)	Eberhardt R	re3	Jackhmmer:A7VAD8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are two completely conserved residues (N and R) that may be functionally important.	27.00	27.00	30.10	37.20	25.40	21.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.60	0.72	-4.24	92	470	2011-05-05 13:27:41	2011-05-05 14:27:41	1	1	362	0	66	290	8	55.00	43	87.76	CHANGED	lshD.....Ph.hLlShlNhKLRDpas.SL-pLCpshslsccpLhpKLsslGYcYctppNQF	..............shDPh.hLhSllNhKLRD.-.as.oLDcLsssa-lDccpLh...sKLsshGacYssppNQF....	0	19	37	53
+13899	PF14057	GGGtGRT		GGGtGRT protein	Eberhardt R	re3	Jackhmmer:A7VAK6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 330 amino acids in length and contain many highly conserved residues including a GGGtGRT motif.	27.00	27.00	46.00	46.00	19.80	19.80	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-12.07	0.70	-5.62	11	294	2011-05-05 13:44:32	2011-05-05 14:44:32	1	2	279	0	48	216	16	313.70	78	97.84	CHANGED	pFEuh-RRhs+IptsLpphGlsSLE-ApplCps+Glcs.pIV+slQPIAFENAsWAYTLGsAlAlK+GspsAu-AAttIGEGLQAFslPGSVADpRpVGLGHGNLuAMLLpEETcCFAFLAGHESFAAAEGAIGIApsANKVRKpPLRVILNGLGKDAAhIISRINGFTYVcTpaDYhTGELclVcE+saSsGs.RAtV+CYGADDVcEGVAIMp+EsVDVSITGNSTNPTRFQHPVAGTYKKtslEpGKcYFSVASGGGTGRTLHPDNhAAGPASYGhTDTMGRMHuDAQFAGSSSVPAHV-MMGLIGMGNNPMVGATVAlAVAVppA	......................h.FESa-RRIcpIpssLsphGIpo....IEEApplCcstGlDsYphlcphQPICFENAsWAYslGuAIAIKK....GC....c....sAA-AApAIGcGLQAFCIPGSVADpRKVGLGHGNLuAMLLcEETcCFAFLAGHESFAAAEGAItIAcpANKVR..KcPLRVILNGLGKDAApIISRINGFTYVpTpaDYhTGE.....LclVpcpuYSs...G.......RAKVpCYGADDVREGVAIMa+EGVDVSITGNSTNPTRFQHPVAGTYKKEplEpGKcYFSVASGGGTGRTLHPDNMAAGPASYGMTDTMGRMHSDAQFAGSSSVPAHVEMMGhIGMGNNPMVGsTVAlAVuVpEA...	0	26	43	45
+13900	PF14058	PcfK		PcfK-like protein	Eberhardt R	re3	Jackhmmer:A7V2F8	Family	The PcfK-like protein family includes the Enterococcus faecalis PcfK protein Swiss:Q82YK9 which is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 137 and 257 amino acids in length. There are two completely conserved residues (D and L) that may be functionally important.	27.00	27.00	33.20	32.90	24.40	23.00	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.85	0.71	-4.04	18	325	2011-05-05 14:36:51	2011-05-05 15:36:51	1	1	168	0	19	230	7	125.50	39	76.36	CHANGED	K.uo-pFKcsIpsYLppRApsDpLFAtsht+ssKNl--ClsYIlscVp.....+...oGss..........uhsD-ElauhAl+YYc..EcsIcssK.slpCpV......sVN+h...lphotccKtcs+ppAhcphppEchpKhpp+spts+.....ttscs...psQ.SLF...Dh	......................so-pFpcsIppYLspRAppDtLFA.shh+ssKsI--ClTYIlsplp......c.......uGCs..........GhsDsElFuhAlHYY-..E-cI-lGK.sls.CpV...............sVNHh...lcLTpEEK....scARppAlcphppEphtKhppcpt..t..........t....p.oLF.....................	0	8	17	19
+13901	PF14059	DUF4251		Domain of unknown function (DUF4251)	Eberhardt R	re3	Jackhmmer:A7V8X1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 164 and 196 amino acids in length.	27.00	27.00	30.40	29.80	26.70	26.00	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.59	0.71	-4.36	50	228	2011-05-05 15:01:04	2011-05-05 16:01:04	1	1	117	2	32	178	4	144.00	26	81.10	CHANGED	s+ppp+pp..................ptpplpphlsscpaplcsspshP...................ppGpsh.Ls.ss..hlplpsDolhspLsa..aGpsas.sPh...GpGulsapushpsaphp.pcKKGshplshsspsp..tps.hphslslassu.sAslslsss.s+psl.....oasGplt	................................t.....ttt..................thppstptlcscpahl-sspsh....................hpGpshhlo.ss..hlplps-pshsplsh..FspsYs.sP....GhGulshsushss..hphp.h-KKGs.hp...l.shslpsh...t.s...hphplslhssu.sAolslsss.sppsl.oasGpl.h..........	0	12	26	32
+13902	PF14060	DUF4252		Domain of unknown function (DUF4252)	Eberhardt R	re3	Jackhmmer:A7VAG1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 182 amino acids in length.	27.00	27.00	27.90	28.80	24.30	26.30	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.90	0.71	-4.67	82	269	2011-05-05 15:12:56	2011-05-05 16:12:56	1	2	129	0	88	266	42	153.50	18	87.94	CHANGED	Kph......hllhh.lhlsshsutu................t.t.phas....capstcshsslslspphhphhsph...........p.cspphtchlpplcslplhs.ts............sp..spsphppphpphhp.....s.sacpLhplp...-.ssppsphhh+tsps....tlpElllhsss.................cp........phsllpltGs.hs.pclsplhpp	........................................h..lhhhh.lhlhsh.hstu................t.p.phFs....ca.pcpcslssVtlsppMh.phhsph.............ps.ph.tplhpplcslplhshpc..............sp........hppphppphpplhp.......s.sappLhphp....-.psppsplhh+tpts....tlpElllhsss.................cs.phsllplpGc.hs.p-ltplht.........	0	34	74	88
+13903	PF14061	Mtf2_C		Polycomb-like MTF2 factor 2	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Domain	Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression [1]. The human MTF2 gene is expressed in three splicing variants, each of them contains the short C-terminal domain defined here. The domain is subject to structure determination by the Joint Center of Structural Genomics.	27.00	27.00	27.00	29.90	26.90	26.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.60	0.72	-4.07	11	173	2011-05-05 16:17:15	2011-05-05 17:17:15	1	3	65	0	92	157	0	48.60	61	8.25	CHANGED	ssshscL+sSlssYFGuA.GRlssGE+apVLARRVTs-GKVQYLVEW-Gsss	......s.pLsHLKsSIosYFGAA..GRlAsGEKYpVLARR.VTs-GK...VQYLVEWEGsT.....	0	12	19	43
+13904	PF14062	DUF4253		Domain of unknown function (DUF4253)	Bateman A	agb	Jackhmmer:C7PV89	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 110 amino acids in length.	27.00	27.00	33.60	33.30	26.50	26.50	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.32	0.71	-4.43	58	204	2011-05-05 16:42:08	2011-05-05 17:42:08	1	17	177	0	57	196	2	108.70	32	25.08	CHANGED	shhlshlPspcsa-lhuhls.h.GuhNpsssssphsAlh+tWp-+aGuhlsulshD.pl-hhlsp....PPtstc-AhplAtEpatFCsDhlcQ...s...............ht..olpsLA.ctLhpsphWaFWW.....D	..................................t.hlshlPsppsa-lhuhls..h.GuhNtsssss-hhAlh+hW.-+aGAh.ssls.a.D.pl-h.lsp....Ps.s.-cAhplAhEpYsFC.PDhl-Q...u................................ht..olppLA.c.sLh.psptWaFWWD......	0	21	46	55
+13905	PF14063	DUF4254		Protein of unknown function (DUF4254)	Bateman A	agb	Jackhmmer:C7P9Y0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 195 and 207 amino acids in length.	27.00	27.00	27.10	27.10	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.64	0.71	-4.59	56	245	2011-05-05 16:45:14	2011-05-05 17:45:14	1	4	231	0	90	244	323	136.60	40	65.79	CHANGED	ltpllhppshhcshpWHhEDlhRcsslsstthhphKRpIDt.NQcRsDhVEhlDsahLpthpsltshs..sA..........plNoEoPuhslDRLSILuLKlYHMp-pspRpD..As.tpHhtpCppKLslLhEQ+sDLusulDpLLsDltsGcKhhKV	.................................................h.tthlah+shl-ssQWHhEDllRcPplss.tshthKRcIDp.NQ-RoDhVEhIDsahhpthpslpshs.....sA..........plNTESPAhulDRLSILuLKIYHMp-pspRsD...ss...s-HhtpCppKLslLhEQ+tDLupAl-pLLsDltsGcKhhKV......	0	34	71	87
+13906	PF14064	HmuY		HmuY protein	Bateman A	agb	Jackhmmer:C7PU21	Family	HmuY is a novel heme-binding protein [1] that recruits heme from host carriers and delivers it to its cognate outer-membrane transporter, the TonB-dependent receptor HmuR.\	   This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 278 amino acids in length.	27.00	27.00	30.60	27.10	25.20	26.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.27	0.71	-4.24	83	274	2011-05-05 16:52:52	2011-05-05 17:52:52	1	4	165	4	92	262	99	176.90	20	72.01	CHANGED	sstssahYhshcssph.........................................................h.ttpttpsssWDlAFpph...slpsNuGs............su.Gpstshh.hs...........................ssasp...........ssshsssssatt..D............................................................................................t.......hshstshssssh................................................................................suWasashs...........................................................................sshhsspsp.lall+s...s-.GpasKlplhsaYssss..................uahoFcYt	.........................................s...spWhYhshpssph........................................................................................t...tpttpsssWDl..AFpph.........pl+sNuGs..........................ts.utstsh....ss.............................sshst.................ssptsssssass...D.........................................................................................................................h.hst....t....hsht.t.shsstth...................................................................................................................................................ssWhshshs...........................................................................sshhssstp..lall+s..........s-..GpYsKlplhsa..hssss..tp..............uhhohpa.........................................................................................	0	37	67	87
+13907	PF14065	DUF4255		Protein of unknown function (DUF4255)	Bateman A	agb	Jackhmmer:C7PSC6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 320 amino acids in length.	27.00	27.00	30.40	29.90	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.97	0.71	-4.83	82	228	2011-05-05 16:56:58	2011-05-05 17:56:58	1	5	188	0	126	237	37	182.90	19	72.26	CHANGED	lstlspsLpsh.Lppthtt.............ssspVsh.ssPsp..........ssttsssplslaLaplpcssth+sts...stpsstt.......hhps.slhlsLaaLloAa..........ssshtpshpl...Lupslphhppp.shl...stpshssth.................................................tthp..plplph.s.hsh-plsclWusL.ssp.apPSlsYplshlhlpssthtsts....sVsphs	..................................lttlspsLpph.Lppth.t.............ssspVsh..ssPsp..........sstt.sssplslaLaslpcssth+spsh.......psspst........hppP.PhhlsLpYLloAa.............spsstpptpl........LupslphLtpp.shl...sspslssth.................................................ttht......tl.p.lt.h.s..hshcplsplWsuL.ssp..h+sSlsYplsslhhtssthts.s..Vtp..s.............	0	38	92	115
+13908	PF14066	DUF4256		Protein of unknown function (DUF4256)	Bateman A	agb	Jackhmmer:C7PN24	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 190 amino acids in length.	27.00	27.00	203.50	203.40	22.20	19.10	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.02	0.71	-4.77	44	212	2011-05-05 17:00:08	2011-05-05 18:00:08	1	1	211	0	53	180	13	172.10	67	92.09	CHANGED	LLpsLKsRFEcNhpRHpulcWspVps+LcAss-KLWSLp-MEcTGGEPDVVuaDpposcYlFaDCSsESPKGRRSlCYD+cAL-uRKcaK..PcssAl-hAspMGIELLTEEQYRpLQpLGpFDhKTSSWlcTPssIRcLGGAlFsD+RYspVFlYHNGA-SYYAuRGFRGhL...+V	.LLclLcsRFEKNMsRHc..GL-WucVpsKLps.s.sEKLWSLsEMEtTGGEPDVVuYDc.cp-EYhFaDCStESPKGRRSLCYDtEALESRKcHK..PcNsAIDhAssMGIELLTEEQYRpLQpLG-FDhKTSSWlpTPs-IRcLGGALFCDhRaG+VFVYHNGA-SYYAARGFRGsLRV....	0	30	45	49
+13909	PF14067	LssY_C		LssY C-terminus	Eberhardt R	re3	Jackhmmer:Q7UW88	Family	This domain is found at the C-terminus of Legionella LssY proteins, which may be a part of the type I secretion system [1]. This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 182 and 195 amino acids in length. It is often found in association with Pfam:PF09335 and PF01569. There are two completely conserved residues (P and W) that may be functionally important.	25.00	25.00	25.10	27.10	21.70	24.30	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.14	0.71	-5.32	48	217	2011-05-06 08:39:08	2011-05-06 09:39:08	1	5	202	0	75	233	29	174.90	23	33.97	CHANGED	hs.pthhhcthPspopshDGh..uDPlNlsll.GspsplpsshtpsGWptscshohpo.hphshuslhcpshstAPVSsLahhGRtQDhAaQp.ssssstp...RaHlRhWpssht..................stssp........shWlGusoaDpGlth.ohhospl.o.HcI-s-lDsERDtlhpslp.tss.httsthhtshsss.....thssss-sahTDGcl	..........p...hp.thphhPspppshsGp..tpPlNlths.Gs.s.tlppthpttGWppssphohps...hlthhhhppshsphPV.shhhpu+spslsht+.sss.ss.p...RphlRhWtssht..................htssp........slWlGuhsh-phh...shhtt.l..h.atht.shD..thshlhttl.........................................................................	0	25	43	59
+13910	PF14068	YuiB		Putative membrane protein	Bateman A	pcc	Jackhmmer:O32109	Family	This family of bacterial proteins is functionally uncharacterised.  Proteins in this family are approximately 100 amino acids in length. There is a conserved FGIGF sequence motif, and many members are putative membrane proteins.	27.00	27.00	43.70	30.40	22.10	21.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.46	0.72	-3.70	21	172	2011-05-09 08:23:49	2011-05-09 09:23:49	1	2	165	0	33	112	0	95.60	60	96.48	CHANGED	s.llIShlLFFVLFFGIGFlLNMLLRtTWlMAllYPIVllhIlsp.thhpYhpsPupuFsulhcclhuLthsDllILsuGhsGAllSGhsI+hLR+pGYQMF	..........llIuMhLFFlLFFGIGFLLNMlLRsTWlM.sllYPIVClhIIs+sshhcYFocPpEoFuShGspVupLutADlhILSoGLlGAhlAGllIKpLRKsGYQMF..........	0	11	24	27
+13911	PF14069	SpoVIF		Stage VI sporulation protein F	Bateman A, Coggill P	pcc	Jackhmmer:O31625	Family	The sporulation-specific SpoVIF (YjcC) protein of Bacillus subtilis is essential for the development of heat-resistant spores. Its expression is governed by SigK [1,2].	27.00	27.00	28.30	28.20	23.00	22.70	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.42	0.72	-4.24	18	195	2011-05-09 08:36:16	2011-05-09 09:36:16	1	1	170	0	38	106	0	78.90	49	91.38	CHANGED	FcslcKKTu..Vs.p-lhKLAsSlpsANhcDEpsVRplI+pVuplAN+PVoKEpEDcIVpAIhsssh.stDhsoLsKMh...KK	.....FsNIEKcsp..VNc-DIFKLAuSVQNANL+DEsslRQLI+pVAhhAs+cVPKEpEDpIVcAIlsssh.PsDFuoLuKMhp..K......	0	10	26	28
+13912	PF14070	YjfB_motility		Putative motility protein	Bateman A, Coggill P	pcc	Jackhmmer:O34438	Family	This family of proteins is regulated in B. subtilis by SigD, and is likely to be involved in motility or flagellin production, Proteins in this family are approximately 60 amino acids in length, and contain two highly conserved asparagine residues.	27.00	27.00	27.10	27.00	26.50	26.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.67	0.72	-4.18	64	334	2011-05-09 08:54:15	2011-05-09 09:54:15	1	1	320	0	92	221	9	58.30	30	94.26	CHANGED	Iuulus.....uhupsphtpp.luhuVhKpuhDspppsutpllph.......h..........t.ussPslGp.slD..................lps	.................huMupupLhps.VshoVLKKuMDsscshh.spLlcs.......h...........ttuspsshGs.slDlhA.....................	0	34	66	78
+13913	PF14071	YlbD_coat		Putative coat protein	Bateman A, Coggill P	pcc	Jackhmmer:O34880	Family	This is a family of putative bacterial coat proteins. Proteins in this family are approximately 140 amino acids in length.	27.00	27.00	65.00	64.80	26.70	20.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.69	0.71	-4.06	18	144	2011-05-09 09:44:54	2011-05-09 10:44:54	1	1	143	0	20	87	0	127.50	56	91.84	CHANGED	ccFKpFV++HPKlIpEVRpGpKTWQ-lYE-WhLhGEDDchWssY+...............tpssspcpc.........pppps-hhsplhshlK+hDssplQpalsphSpuIuulQsllsQFpssspppt.......tptpp.PFSFRKD	.pQFKEFVp+HPKhl+EVRuG+KTWQQFYEEWYLLGEEDPIWssYR..................tp.tEscccp-s.+sE.................EEKouDlMGQMLSahKKLDV-QMQcHLANVoSAIGSVQQVlQQFQGs+oQQc......psoSEsNPFhFpKD............................	0	3	12	14
+13914	PF14072	DndB		DNA-sulfur modification-associated	Bateman A, Coggill P	pcc	Jackhmmer:O34448	Family	This is family of bacterial proteins likely to be necessary for binding to DNA and recognising the modification sites.  Members are found in bacteria, archaea and on viral plasmids, and are typically between 354 and 474 amino acids in length. There is a conserved DGQHR sequence motif.	29.00	29.00	29.00	30.30	28.50	28.90	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.10	0.70	-5.31	64	426	2011-05-09 10:06:35	2011-05-09 11:06:35	1	2	328	0	110	399	165	326.50	18	79.94	CHANGED	aPAl+GhQus+..............paYhshhPh+hl...s+lhhhsp.p..phssphR...........................uQR............sLNcsRlscIscYl.lp.........................N.p..sYl.huul.Tusls...s.shthp...h...............ttts..t.plGhLpls..hDu.c....hhlsDGQHRpsAIc.......pALc......csP...p.......Lup-..............sIuVlha....h-tuLc+sQQhFuDlNptuh+sssSls............hhYDcR-.s..hutls+plh.....ppsshap...shs-hccssluppup+LFT.lsslhpusptLh....................tptttsph..cpttphsppFWptl.spphs-...Wp.lhppphss......tphRpchlpupulsLpAlGhhupt..........lhppt.........spphcptlptLpp....lDWs+ss.......W.....ps...+sh..psp.................lsps..psslpLssstlcptlulsLs	...........................................................................................shph.p.s.t.t......ha.hhh.hp.l....clh.hsp.....p......p.s.p.t...............................hQR..........................slsps....+l.p.c..Itc.Yl....p................................................................................stp.......shl...hs.sl.shshs....t..thphp.....h..............................................tssshGhLpls........cs..p.................hhllDGQHRhtAlp.................................puht.................................p........p..........................lsp..........................................plsVh..ha.................hs.shcc.p.pp....h..FhslNppthhsssslh..................................h.hsp.cc............shlsppls.................pts.ht...............shhc...h.t.....p.....s...s........tpp..ptlh........o..hssl.hph..hp...thh.............................................................sttp.tphhp....hhppaaptl..tphhst......hp.......................................p....p.h.h.h....p.s....h.hh.slu.hh.t.........................h.......................................................................................................................t.......................................................................................................................................................................................	0	27	75	97
+13915	PF14073	Cep57_CLD		Centrosome localisation domain of Cep57	Coggill P	pcc	manual	Domain	The CLD or centrosome localisation domain of Cep57 is found at the N-terminus, and lies approximately between residues 58 and 239. This region lies within the first alpha-helical coiled-coil segment of Cep57, and localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component.  This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, Pfam:PF06657, is the microtubule-binding region of Cep57.	27.00	27.00	27.40	27.20	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.26	0.71	-4.44	8	162	2011-05-09 10:19:16	2011-05-09 11:19:16	1	3	48	0	73	143	0	161.50	53	39.03	CHANGED	AllSALKsLQEKIRRLELERsQAccslppLSREusca+csL....................cc-ppp+shtpp-hopp.........pp-lspQLsuAEuRCoLLEKQL-YM++MVcs.s-+E+sslhEpQspLpREppppQhclpupLcKL-lLEpEapRLTsTQusAEcKIppLEcKLpEEEpQRKLhQDKAucLQTuLEsN+lll	...........................Alh.ALKsLQ-KI+RLELERhQAE-sl..ptLS+Es....hp.YK..KsL....................-...p...php.ERp.u+pE..Kp...............pp-ls.QL.uAps+CsLLEKQLEYh+pMlhp.sEtE+shlLEp.Q.spLpRE+...p........p.DQh+.l..pupLEKLDlLEpEh.+LTshQthAEcKhpcLEpKL+EEEppRKhhQcKA.upLQTGLEhs+llh..............	0	13	18	34
+13916	PF14074	DUF4257		Protein of unknown function (DUF4257)	Bateman A	pcc	Jackhmmer:O34881	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	27.00	27.00	30.20	30.80	26.30	25.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.67	0.72	-4.33	11	133	2011-05-09 10:32:23	2011-05-09 11:32:23	1	1	114	0	10	61	0	80.20	64	70.66	CHANGED	plllAslIGGlhGlluH.lpp+G+lphP..........................................Rp.....s+phaalGFltDhhlGhhAulLhV.lhs..cspohhpllhlSIluGlGGEuhLhS	..QWLTAlLlGGITGFVSHLINN..QGKLLLP............................................RR.....LKTFFHhGFLTDIFTGSLAALLGL.VLF..DVTsIKEIIKVSIVTAISGQTFLLH.	0	1	4	5
+13917	PF14075	UBN_AB		Ubinuclein conserved middle domain	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	Ubinuclein 1 and 2 (UBN1, UBN2) are members of a histone chaperone  complex involved in the formation of a certain type of facultative  heterochromatin, called senescence-associated heterochromatin foci  (SAHF) [1] [2]. The domain described here is conserved in many  eukaryotes such as human, rat, drosophila, and zebra-fish and has been  targeted for protein structure determination by the Joint Center  for Structural Genomics.	25.00	25.00	25.00	25.00	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.48	0.70	-4.66	12	163	2011-05-09 11:56:05	2011-05-09 12:56:05	1	5	79	0	96	141	0	196.10	46	21.34	CHANGED	LPpsLsscllpplsslK-hu+.h.chsG+ppFF-sclssLLLclt.phppss..pstRstVapHLEtpLpssK.slh++hKpl+lccpcs+hppsLpKL+cAlscsMPctlssYEhEppphsptpsu..................cpsuEc.P.....ph+hPRKKFpWs-plRpLLhclhpl+hpSatl.t.pRppShE-alpu...aLcpcVhsLWPpGWMphcpLpKEl	................................................LP-.GLPs.Lc++lc-Lp...........AA+hh...-tEG+pKF.Fop-hNslLLDIElQhp..Els....stlRSuVYuHLtuFlPCsK-oLlK....Rh.KK....L...+L...................p.....Q....c.s..RL+EPLpKLK.AlupsMPEQlt+Ypc-CpA+spsKsA.........hpt-.p-.cpp.....................s-.--D-E+ss.......+RlhGPR.....KKFpWsDpl.RpLLCplVclKLtsY-LEt.s+u.......pShED....alKs...........Fh-........s....EVKPLWPK.GW..MQuR.hLaKES................................	0	28	35	57
+13918	PF14076	DUF4258		Domain of unknown function (DUF4258)	Bateman A	agb	Jackhmmer:Chitinophaga pinensis 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 95 and 124 amino acids in length.	21.60	21.60	21.60	21.60	21.50	21.50	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-9.25	0.72	-3.97	112	331	2011-05-09 12:23:19	2011-05-09 13:23:19	1	5	278	0	128	317	58	71.80	19	55.93	CHANGED	hhop.H.Ahpchp..pRp.Ishp-lhpsl..tp.Gclhcphs....sst.tssplhlttstppt............slcllhshsps.....hhhllTlahs	...................hopH.Ahp+hp...cRs..Ishpplhpsl....pp..Gclhct.........pst.tss.phhhthstttp..................lpllhshpps......hhllTsa......................................	0	56	95	118
+13919	PF14077	WD40_alt		Alternative WD40 repeat motif	Weichenberger CX	pcc	Joint Center of Structural Genomics (JCSG)	Family	WD repeats are short subdomains of about 40 amino acids and fold into 4 antiparallel beta hairpins. This domain here has been detected on the C-terminus of WD repeat-containing protein 18 during target selection by the Joint Center for Structural Genomics.	25.00	25.00	38.30	64.70	24.30	21.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.27	0.72	-4.33	4	42	2011-05-09 12:27:19	2011-05-09 13:27:19	1	5	31	0	22	35	0	47.50	63	11.27	CHANGED	huush-KslhGst-pL+lRVuELEEEVRsLRKIN+DLFDFSTRIIT+P	..hsooh-KsVLGsQ-pL+lRVoELE-EV+sLRKINRDLFDFSTRlIT+P...	0	1	3	7
+13920	PF14078	DUF4259		Domain of unknown function (DUF4259)	Bateman A	agb	Jackhmmer:C7PLU1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 118 and 145 amino acids in length.	22.70	22.70	24.10	23.40	22.30	21.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.73	0.71	-3.64	61	249	2011-05-09 12:29:06	2011-05-09 13:29:06	1	6	214	0	67	189	4	121.80	20	66.43	CHANGED	GuWuhusF-sDsuhDhls-Ltct.............thhpthhcsshhs..tspchl-s--stsuluuAtllshh..........hsssh.ssthtt.............................ttpssppltphAhphlcplhst...SEhh-LWp...ps..tth-pWhpslp	.....GuWuhthF-sDsuhDhlsplp-h.............ttpthlpth...tpthhhs...tttsth-hc-s...t...s...sluhAtlhhth..........t.sssh.sss..h.t.............................htph.ppltphshphlcph.t........tt.hphW.p.........h.t.......................................................................	0	18	51	67
+13921	PF14079	DUF4260		Domain of unknown function (DUF4260)	Bateman A	agb	Jackhmmer:C7PFK4	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 114 and 126 amino acids in length. There is a conserved GLK sequence motif.	27.00	27.00	32.20	32.00	26.40	24.30	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.56	0.71	-4.26	24	197	2011-05-09 12:52:38	2011-05-09 13:52:38	1	1	193	0	65	166	5	108.60	44	92.15	CHANGED	sctllRlEGhslhssulhhYuhhs..huWhlahlLlLsPDLSMlGYLhGsRlGAhsYNhsHoahhPllLlslGlhhssshs........htlulIWlAHIGhDRhLGYGLKYssuFccTHLGRl	......................+tll+hEshslh.lhslhhYs..h..hp..aS.W...hlFhlhlLsPDLSML.....uY.hhss+lGAh......lYNlhHoYllslllsllGlhhp..shl........lhlu.LI..WhAHIGhDRhhGYGLKYp.ssFcpTHlt+l..........	0	20	46	55
+13922	PF14080	DUF4261		Domain of unknown function (DUF4261)	Bateman A	agb	Jackhmmer:C7PC06	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length.	27.00	27.00	27.30	27.30	26.60	26.50	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.50	0.72	-4.17	52	353	2011-05-09 12:56:15	2011-05-09 13:56:15	1	16	297	0	40	258	2	77.10	31	21.46	CHANGED	hThGhpsFsh.-lphh...pshcsp-lhpaLhslutYllppsss.lp-G-TI.Ghss......ppphphptppu.....lts..sp.s.LcIp	.........YThGhcsFsc.ElElps...tsh-sp-lh..hlhslshYlLppDss.LcDG-Tl.thp-.........spphphpcspu.....lts..ppts.LcI............................	0	21	29	34
+13923	PF14081	DUF4262		Domain of unknown function (DUF4262)	Bateman A	agb	Jackhmmer:Q50763	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 147 and 227 amino acids in length. Swiss:Q50763 is incorrectly annotated as the KatG protein.	27.00	27.00	30.00	29.60	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.75	0.71	-4.01	54	189	2011-05-09 13:06:11	2011-05-09 14:06:11	1	2	171	0	54	153	10	117.50	29	65.65	CHANGED	pltcpGhslhtVhscppsss...........aua.olGh.pphshPEl.llhGL.shphspshls...plsptht.tsc...h......Gtthpph.......tsh.shhh.lt...ht..hhh.u..hat.............h.slQhlasDtpGhh.......PWc.shs	......................lhpaGWslhtV.s-cps...............auYTlGL.sphshPEL.llhGL.sschupplLNthucc.hh.sGch...hssGhphsth.........ts....lthhpVspschc...hhhA.hhhat...........sph..sLQllWsDpcGpa.......PWpssh.........................................	0	17	40	52
+13924	PF14082	DUF4263		Domain of unknown function (DUF4263)	Eberhardt R	re3	Jackhmmer:Q7UE31	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 244 and 403 amino acids in length.	27.00	27.00	27.70	30.50	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.04	0.71	-4.29	61	136	2012-10-11 20:44:47	2011-05-09 14:08:03	1	3	127	0	43	141	11	162.50	19	47.31	CHANGED	Lpss...t............sEppaQphlcps.shlh...shtasthh...........hh.schp...hssphhsDFlhhstssshh.......llEIKpPs..pslhsp..........ssh...t.up-lspAlsQlhcaht.hlppptsphptptptt...........................shps+slllhGcp.........phhsppppcshchhppph...t.slcIlT...aD-Ll	........................h.....t...sEpphQpahcps..shlh......uhtast.h...........hhh...schs.......hssshhsDalhhstssshh.......llElKpPs...spl.hpp...........ssh..........t.ut-lspAlsQlhsaht.hlppphsthptp.pht..............................shpscshllhGpp.........p.hsppp.pcsh.chhppph....t.plpllTaDpLl..............................	0	15	31	39
+13925	PF14083	PGDYG		PGDYG protein	Eberhardt R	re3	Jackhmmer:Q7UEH4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There is a conserved PGDYG motif.	27.00	27.00	27.40	30.30	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.59	0.72	-3.65	6	78	2011-05-09 13:16:29	2011-05-09 14:16:29	1	1	76	0	24	63	18	101.70	77	69.33	CHANGED	GP...............NRYtPGDAllTGuTGDRWVVSR-RFDs+Y.shsPs.sHGcsGAYRN+P.lsVLA+cMscsFsIARSs.GGDVL+GssGDWlMQYA........PGDYGllppARFupVYR	.................GPNRYssGDALlTGSTGDRWVVSR-RFDAKYlPsssuhAHGpPGAYRNRP.AVVLA+RMDtPFoIARSA.uGDsLRGsAGDWVMQYA........PGDYGVVQApRFAQVYR.	0	3	7	15
+13926	PF14084	DUF4264		Protein of unknown function (DUF4264)	Bateman A	pcc	Jackhmmer:P54395	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	28.70	28.60	19.80	18.30	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.87	0.72	-8.31	0.72	-4.59	25	183	2011-05-09 13:37:37	2011-05-09 14:37:37	1	2	183	0	47	86	0	50.80	62	89.49	CHANGED	KlElluohchppscDhYKlVDFLN+TLK-cslhFGLohspc.....cschlhoIYcT	.KIElLuThclchosDLYKIVDsLNRTLK-pcLMFGLALDEc....c+cpAVFTIYRT.	0	22	36	40
+13927	PF14085	DUF4265		Domain of unknown function (DUF4265)	Bateman A	agb	Jackhmmer:Chitinophaga pinensis 	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 139 and 168 amino acids in length.	27.00	27.00	28.00	34.10	25.40	25.30	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.53	0.71	-10.13	0.71	-4.35	42	117	2011-05-09 13:38:35	2011-05-09 14:38:35	1	2	102	0	45	106	14	114.70	24	73.85	CHANGED	sEslauc.hls..ssp.aclpssPaashulAhGDllpsppss..tthhhpch.ttuGssTlRlhh.pss.........hpplhsplpthGssh-shpt..shlulslPspsshpslpphLsp.hpcpshlpa	.........Etlaup.hhs..ssp..atlpslPaas.slAhsDllphcpcc..thhhhpcllpsSGNsTlRllhhspt........hpplhsp.lp.p.hGsphEt.st..shlulslPspsshpslctlLsp.hc-pshhta............	0	18	22	33
+13928	PF14086	DUF4266		Domain of unknown function (DUF4266)	Bateman A	agb	Jackhmmer:C7PCX1	Domain	This presumed lipoprotein domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 50 amino acids in length.	27.00	27.00	39.50	39.50	25.10	25.00	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.47	0.72	-3.45	47	129	2011-05-09 13:43:10	2011-05-09 14:43:10	1	1	108	\N	61	131	37	49.90	44	58.12	CHANGED	VpPaE+shLAcs-Msh.spcshcsshspHlY.u+Euu.uGGtGhuGGGCGCN	.VcPaE+spLAcs-MsL.spcshctthspHlY.s+Euu.uGupGhuGGGCGCN.	0	21	45	55
+13929	PF14087	DUF4267		Domain of unknown function (DUF4267)	Bateman A	agb	Jackhmmer:C7PBL0	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 126 and 142 amino acids in length.	23.00	23.00	23.50	25.10	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.68	0.71	-10.30	0.71	-4.48	58	194	2011-05-09 13:46:48	2011-05-09 14:46:48	1	5	140	0	133	197	3	111.20	22	73.37	CHANGED	hushhlshGlthllp.PppAhshFGl.......Pts........................pptssuh....hhlhGsRDlshGlslhshhhh...............ust+ulGhhl...................lusuhlsluDuhlshp...........tGssttsh...Hhs.....husllsshGhllh	..............................uhhhlhhGlth.lhs.PttuhttFGl.....Ptt......................................................................pssspuh....htlhGsRDlshGlhlhshhht...............uph.cslGhhl...................lssuhlsluDshlshp..............tus.ttts.hh..Hhs.....suslhhshuhhh.h............................	0	31	77	114
+13930	PF14088	DUF4268		Domain of unknown function (DUF4268)	Bateman A	agb	Jackhmmer:C7PAS6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 151 and 387 amino acids in length.	27.00	27.00	27.30	28.50	24.90	26.70	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.68	0.71	-4.52	63	189	2011-05-09 13:50:04	2011-05-09 14:50:04	1	8	179	0	68	194	80	136.50	22	45.35	CHANGED	pl+p.cFWpphhcphpt...............tshps.scpWlshso.Gl.puhshphhh........spc..cspVpl.lscss..tt.scthF-pLhppKstIE...sphGt.cLpWpc..hs-..+ctsRIh.hhtpsss...lhscspWschhpahscphpph-phatthlpt	....l+pcFWpphhcthttp.......h....t.hpstscpWlsh.ss....Gl.pshphphhh..........spc....pspVpl.Iscss.....ppthF-pLhp.hKstlE...pphut...sl.Wcc....hss.......+csuRIh.hh.t.psls...ht.scssWsphhcahhcphhphcphatth...h...............	0	25	53	62
+13931	PF14089	KbaA		KinB-signalling pathway activation in sporulation	Bateman A, Coggill P	pcc	Jackhmmer:P16449	Family	This family of small proteins is found in the membrane and is necessary for kinase KinB signalling during sporulation. There is a conserved GFF sequence motif. The initiation of sporulation in Bacillus subtilis is dependent on the phosphorylation of the Spo0A transcription factor mediated by the phospho-relay and by two major kinases, KinA and KinB.	27.00	27.00	102.00	101.70	21.10	20.60	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.26	0.71	-4.73	22	164	2011-05-09 13:52:14	2011-05-09 14:52:14	1	1	164	0	30	125	0	176.80	61	88.75	CHANGED	GulsssIlGhllcaspa..hhhsh-hspllusllahlGlGhh.aSlISQMGFFAYLTlHRFGLuIFRShpLWNtVQllLIhFllFDLlYhRahsFuppspuhhtYlhlslllLlhullVAalKsKpT.NKsAFlPALFFMlVlTslEWhPALpls-pp...aLahhlhPLLsCNAaQLLhLH+lp	................................GGloTsIlGFlLcW-c.YsphFtsF.-stEIluV..FWlhGVGFIFSVISQMGFFAYLTlHRFGLGhFRSuS.LWNhVQLFhIAFVLFDhVYLR.lhh...AsucsSlus.ILlAshLhhFGsIVAYlKoKpT.NKKAFVPALFFMVVVTlLEWVPALRINDsD...WLYLMlIPLLlCNAYQLLlLHRL.l......	0	10	21	24
+13932	PF14090	HTH_39		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:C7PBH6	Domain	This helix-turn-helix domain is often found in phage proteins and is likely to be DNA-binding.	21.30	21.30	21.30	21.50	21.20	21.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.17	0.72	-4.50	51	254	2012-10-04 14:01:12	2011-05-09 14:58:04	1	4	222	0	46	207	80	65.50	28	53.69	CHANGED	sQptclLstLpptss.lTshEAhpphslhc..huuRIp-....LR.ppGa..pIpTph....sppGp.c.+lupY...sLhss	...............ppppllttLppstt..lTsh-uh.pphushc..lu..AcIhc....LR.ppGa....sIhTpp....sphstsptpVstYhL..............................	0	8	24	37
+13933	PF14091	DUF4269		Domain of unknown function (DUF4269)	Bateman A	agb	Jackhmmer:C7PAK4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved KTE sequence motif.	27.00	27.00	28.80	27.30	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.69	0.71	-4.27	29	134	2011-05-09 14:02:34	2011-05-09 15:02:34	1	3	131	0	33	105	1	145.80	57	81.68	CHANGED	acslpchplhctLtsa..sPlLsGTlPlsIDlssSDLDIlCpsp......D.hptFpptlpshauphps.FphcptpI.psh.sllssFphpsathElFuQshPsppQtuYRHMhlEp+LLphttssh+pclhpLK.cpGlKTEPAFuchLul.s....G.DPYtsLLph	........................Y-VLscLsIMEcLAlY..sPVLsGTIPIcIDs.pSDLDIlhEVp......N...aDsFEQch+SLYGoa.cG.FpIK+.KcI.+ssESIp...........VNFcaEGF-FELFAQP+PV+sQNAYRHMlVEHhLLhp+.P+lREEIl+LK.EpGLKTEPAFAQlLsI.s.....G.DPYEtLlh.L..	0	16	28	29
+13934	PF14092	DUF4270		Domain of unknown function (DUF4270)	Bateman A	agb	Jackhmmer:C7PAW4	Family	This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 444 and 534 amino acids in length.	27.00	27.00	61.00	60.80	21.00	20.00	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-12.91	0.70	-5.86	72	233	2011-05-09 14:05:54	2011-05-09 15:05:54	1	2	191	0	63	235	345	458.80	20	93.05	CHANGED	lGtsllss.s.shssphsshshsspohht.....s.......uVhops......shs...hlGphsDs....aGph.pusahsQlshs....ss..sa.ss.sp.........................................lDSlhlhl.Ysu.................................................................................aG.Dohss...h+lslaclsp...l.................sptaYoshss....ps.........thlush...............sassss...................................shssplplpLsps.............aspplh...ppsp............h.hpsspsFh...shh+Glalpsst.......usGshhhls........ssplplaYphpspsstst................s.....hshss.........hphsphpss.ss...lsplht..pp............sYLKussGhhsplsl.......................slppltp.........p............tp.slNsApLshhh.ss......st..................hshshPpplhLhptcpt..............pshhppsth.sst..ssahuhhp.....................ttpsspYsFs.hs.t.lpshltt.....................pt................ts.chshhlhlsltspss...............tt...........hht......stsshLhGspss............................ppl+LplhYoph	................................lGtslhss.s..phss.phss.hs.ssspohht...s.............ulho..ps..............sss......hlGph.sDs....aGph.pusahsQh.pss....ssh.sF.sttst..........................................lDSlplhlhYsu....................................................................................aG...Dohss...h+lslacLsc..sl.....................tpsptaYoshs..s.hps..........phlust................................sassss.t............................t...................shssplclpLscp.............aGpplh........pttp............t.hpssppFh...phh+Glalpsst.......usGslhhls.........ssplplaY+hptp..sssspst..............hs........hshss.................hphNphpss.ss...lpplhstss................psYL+ussGhhsplsl.......................slsplhp...p........................ppsslNsApLplhh.ss........shp.................hshshPpplhlhptcpt......................pshhppsphssst....ssahuhhp......................spsspYsFs.hst.lpshlps................................pt..................ts.chs.hhlhlslphpts..............................t.ht...................sttshLhGssts............................ppl+lplhYop...............................................	0	23	55	63
+13935	PF14093	DUF4271		Domain of unknown function (DUF4271)	Bateman A	agb	Jackhmmer:C7PG02	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 221 and 326 amino acids in length.	24.20	24.20	24.30	27.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.82	0.70	-4.65	53	191	2011-05-09 14:10:02	2011-05-09 15:10:02	1	1	190	0	53	188	97	205.80	23	75.26	CHANGED	alshlllhshhl....lshs+thhhpphp..sFhhhhhppphhhtpsspph.....haphhhhl.sslhhulhh.....ahhhppht.thhhsh............hhhhshh.hshhhhahlhKhllhphluhlFh.cchhptahhphhphhshh.ul.lLhPlsllhsYhs........hshthhhhhhlhlhllshllhlhpthplhhpphht.hahILYlCALEIhPhllL.aphlh	........................lshlLlssFhl..hhhshs+phh.pphp....sFhhht.tpsphhtspssp-h.....tapl.hLhltsslhhulhh.....ahhhpthtsthhtps............hhhlshh.hshhhhahlhKhllhphluhlFhscpt.sp.ahtshhtlhhhhGh..hLaPhsllllYhs........hslphhh.hhhlhlh..lh.spllhhh.+thplahpphhs.hhhILYhCuLEIhPhllL.aphl.....	0	22	47	53
+13936	PF14094	DUF4272		Domain of unknown function (DUF4272)	Bateman A	agb	Jackhmmer:C7PHI5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 221 and 399 amino acids in length.	27.00	27.00	29.30	28.80	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.53	0.70	-5.33	39	169	2011-05-09 14:13:04	2011-05-09 15:13:04	1	2	163	0	51	163	7	198.20	29	67.51	CHANGED	R+t+ohphLppp.Glshh.ppLPsl..sps-sphRstcElspRAlAlhhlshhAps............tpstphhh.phl.cpasl.hphLTspE+pal...sspss...........cpthhphsW+YEuhasLhWALGhl-..pLshPsplC...Dsshshphhtph.ts.hsphhpp..splRshsEILDttDLhYRh...cWAsVcARl..pstsssu.....slstsVVhER+hALsWLls.............ht...sps.........WDcl	.............R+tpshphLppp.Gl.h...tpLP.l..stppsphRstc-lspRslsLhhlh.tAttl.................tpspp.hh..phl.ppasl.hphLTspEpthlt........ssps.c................tpthhphsW...+Y.EuhhsLhWuLGllc..pLshPschC...........Dsthhh.p.hhtph..t.....p.hpphhpp..sphRshpElL-ttDhhaRh...cWAshcAch.....pspsssu...........sls.ulVhER+huLsWLls.............h.stt.........WDpl......................................	0	21	36	43
+13938	PF14096	DUF4274		Domain of unknown function (DUF4274)	Bateman A	agb	Jackhmmer:C7PQU5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 80 amino acids in length.	27.00	27.00	31.30	34.00	23.40	24.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.52	0.72	-4.18	39	134	2011-05-09 14:22:07	2011-05-09 15:22:07	1	2	114	0	32	115	6	78.00	25	44.42	CHANGED	hsoscplahhstpaN......aD.s...shplhphllppspCDhuTALhlaWhh.......sstha.hp...........ptptsphhp-t.hphlpplhc+hhs	........soscpLahlsssaN......WD.s....uhcl.ptIlcpspCDhuTALhhFahs.......suhha.hp.t.........tt.sssh.p-h.hphlppltc+hh.t....................	0	10	16	22
+13939	PF14097	SpoVAE		Stage V sporulation protein AE1	Bateman A, Coggill P	pcc	Jackhmmer:P40870	Family	Members of this family are all described as putative stage V sporulation protein AE, although this could not be confirmed. Proteins in this family are approximately 190 amino acids in length.	27.00	27.00	28.00	199.60	21.80	19.70	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.16	0.71	-4.88	23	159	2011-05-09 14:32:09	2011-05-09 15:32:09	1	1	159	0	34	84	0	178.80	67	93.72	CHANGED	+VILVTDGDphA++slEhsA+plGGRCIStSuGNPohLoGpcLVcLIhpsspDPVlVMFDDsGhhGcGsGEpAhcaVssHssI-VLGslAVASsTcts-hs+VDlSIDRpGcls-huVDKpGhs-hc..t+lpGDTV.sLcpL.slPlIVGIGDIGKMstpDchc+GuPITp+AlchILE....RS	...lhVTDGDEYAKRTIEllsK-hGGRCIStSpuNPT+LTGcclVELIhQTPYDPVFVMFDDSGalGEGuGEcALKYVATHcpI-VLGlLAVASNTHphEWsRVDVSVDRsGsLTEYGVDKaGlP-sE..lGRIsGDTlYCLDcL.sVPVIVGlGDIGKMsGsD-a-+GSPIT+KAIpLILERS......	0	16	26	29
+13940	PF14098	SSPI		Small, acid-soluble spore protein I	Bateman A, Coggill P	pcc	Jackhmmer:P94537	Family	This family of proteins is putatively assigned as a small, acid-soluble spore protein 1.  Proteins in this family are approximately 70 amino acids in length. There is a conserved LPGLGV sequence motif.	27.00	27.00	36.30	49.20	19.60	17.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.08	0.72	-4.05	20	184	2011-05-09 14:51:40	2011-05-09 15:51:40	1	1	184	0	35	94	0	64.70	59	90.65	CHANGED	hNLRpAllsNlpssop-pLccTIsDAIpsGEEKhLPGLGVLFEshWcpussppKpphlpsLcpuL	.hNLRsAVlANVoGNoQ-QLp-TIVDAIQSGEEKMLPGLGVLFEVIWcsAsEsEKcEMLcTLEpGL..	0	9	22	26
+13941	PF14099	Polysacc_lyase		Polysaccharide lyase	Eberhardt R	re3	Jackhmmer:Q7UP23	Family	This family includes heparin lyase I, EC:4.2.2.7.\	\	  Heparin lyase I depolymerises heparin by cleaving the glycosidic linkage next to an iduronic acid moiety [1,2]. The structure of heparin lyase I consists of a beta-jelly roll domain with a long, deep substrate-binding groove and an unusual thumb domain containing many basic residues extending from the main body of the enzyme [2]. This family also includes glucuronan lyase, EC:4.2.2.14 [3]. The structure glucuronan lyase is a beta-jelly roll [4].	29.90	29.90	29.90	30.30	29.80	29.80	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.68	0.70	-4.69	54	240	2011-05-09 14:57:12	2011-05-09 15:57:12	1	21	167	6	118	254	933	233.50	15	63.76	CHANGED	tshshpushpssshsphpp..ttsstps..........................sssshpGp.................hAl+hphp......hsss.st.......................ut.RuEl.....ptsshphusphaYsauh...hlspsas................ss.p..hlsQa+tps....s...................................................tpPshtlhl.......pssphthphtsss...........................ts.tttphhshsslpt..GpWpchslcs+Wuss........psGhhclWh..........sG..phlhppps.ssthss.................pt......ahKhGlYpsshppsss............laaDplth	................................................................................................................t............................................................t....s...................shp...........tss.......................................sp.RsEl...........tt.th..thGpshhYsauh...hlss.s.at................ss..ptthlsQa+sts...........................................................................stPs.htlth.......pssphhhphpsss........................................................tstphshhhshs..s...hst.....upWhchhlphcasst...................psGhhclah..........sG....ptl.hp...tps...tshhss.................spsh..hhKhGlY+ss.ps........................h.........................................	0	41	77	100
+13942	PF14100	PmoA		Methane oxygenase PmoA	Eberhardt R	re3	Jackhmmer:Q7UPP4	Family	This family is a putative methane oxygenase [1]	27.00	27.00	39.80	38.00	21.90	21.00	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.82	0.70	-5.19	65	174	2011-05-09 15:14:35	2011-05-09 16:14:35	1	6	100	0	95	187	116	281.70	25	73.69	CHANGED	sspslsl...thsG.p......lspYhas........ht......ss....+PalHPlpoh.uGsslTch...........pPtDHsHHpGlhhuhscVs....s....hsFWsspshh................tp.Gphtapshpthps....ssstupl...spclsW.hst......sGph.lLpEpRslshpss....st..............shhl-asssLs.....................sssp.slshs...ss............tY.GGhthRsspsh............................ssuplhsutG............tpGps..........shGpp....us.........WlshsGph.......ssp...............tsslshhscPsN.......thP......s.WasR...shuhhusssssth.........ptshsls...sGcslph+YRlllt-Gsh.sssc.lsshhppa	........................s..thsl.thsG.p.lhpYhhts.........hpss.....+PalHPlpTh.uGss.lTch............pPsDH.....hHHhGlhhuhscVs........GhsFWsspshh...................pp.Gphpppshpthts....ststsph...spplsW..hst......sGp....lLpEpRslshpsh....sst..................sahlDhshsLs.....................sssp.slphs.ss............sY.GGhhhRsscph............................ssuplhsutG...................tpucp...........shGpp....us.........WlshsGph.....................sst...............ts.olshhspPsN.......ths......s.WalR....sts.hhusssuhsh.........ptphsls...sGcslph+aclllt-Gth..stsphsthhpt....................................	0	48	79	95
+13943	PF14101	DUF4275		Domain of unknown function (DUF4275)	Eberhardt R	re3	Jackhmmer:Q7UUJ6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 140 amino acids in length.	27.00	27.00	31.60	31.50	20.20	18.50	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.03	0.71	-4.11	13	119	2011-05-09 15:22:53	2011-05-09 16:22:53	1	1	112	0	16	94	1	132.80	57	95.41	CHANGED	ME....lhchLcp..+slKlpEhspWGshhRKpWEcpFAsHLohcEKcpIhlhsscshs..GYLWHlFSY-p+...sCLcGcEAcpAFcpcpKssCYlFaQasD-slllEcAspLpAsDL.s.......Eh......DlYVVDc-FsWTaVhTHEscahGPYFs	......................ME.hl-hL++..KshKVREhpp.WGsYFRKRWEDpFAN.HlScEEKE-IaLYsDchsC..GYLWHIFSYE+K...KCLEGcEAEpAF+sEsK+-CYIFYQHsD-VLl.lcDAShLph-Dllp.......Essp...ha+uDlYIVDK-FTWTFVKTHEccW.CGPYFs.........	0	6	10	12
+13944	PF14102	Caps_synth_CapC		Capsule biosynthesis CapC	Eberhardt R	re3	Jackhmmer:Q7UXU8	Family	This family of proteins play a role in capsule biosynthesis. They are essential for gamma-polyglutamic acid (PGA) production [1].	27.00	27.00	35.60	29.30	24.20	26.90	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.53	0.71	-3.99	31	208	2011-05-10 07:29:10	2011-05-10 08:29:10	1	2	193	0	50	120	38	120.40	43	66.61	CHANGED	slGlllSLlasEpsGlssGGllVPGYlALhh.spPhplhlslhhSllTahll.phlu+ahl.......lYGRR+Fshhlllull........lphlhphh..h......................h..phpslGhIlPGLIAsphp+QGlhhTls	...............lGllLSLlFsE+hGlsPuGLVVPGYL.ALhh.spPlhllsllllSlLTYhIV.pslS+ahI.......LYGRRKFAAhllsGhl........L+hlhchl..h...............l.ssFths..-hpuIGlIlPGLIANoI.p+QGlshTl.h...........	0	18	37	47
+13945	PF14103	DUF4276		Domain of unknown function (DUF4276)	Eberhardt R	re3	Jackhmmer:Q7UYP7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 190 and 224 amino acids in length. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	27.40	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.29	0.71	-4.45	56	288	2011-05-10 07:40:08	2011-05-10 08:40:08	1	2	220	0	123	324	17	189.50	16	90.84	CHANGED	llEtsotpphLcslL.+hh........thphphhshthc.slppphscph..+sapphh..........stllllhDpDs.ssstphppp......p.htp.t..tpt..............s+lsspEhEuWaLuD.hpAl..pphhsph.sphsh.......tt.pKhpsP-sl.susppt................tspYp......Ksptuptlustl......shspsp.S.SFpp.....hlpulpph	....................................................................................................hhEs.o.ppthlpt.ll..hh..........................th.h.hh.h.ht.pht.tt....hs..t.th...............pthpp.h.t.....................shlhshhD.....h.s...hss....st...ttph................htt...........t...h.............s...t.......phhshlt....hcEhEuWhhuD.h.p.u.l..tphhsp......tphth...................t.htpht.sP-plpsu..sppt......................thhstYp.............Ksh..tu...tlstpl.....s.phhppp....sspFptalptlt...................................................................................................	0	44	88	113
+13946	PF14104	DUF4277		Domain of unknown function (DUF4277)	Eberhardt R	re3	Jackhmmer:A8ZKM0	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 110 amino acids in length. There is a conserved NGLGF sequence motif.	25.40	25.40	25.40	25.60	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.27	0.71	-3.89	23	342	2011-05-10 07:59:00	2011-05-10 08:59:00	1	2	80	0	129	362	22	108.60	39	26.46	CHANGED	Mp.........p.pl...+sLDHLGlVAGlhDElslschIDchLspcppc+.lSpGpslKAMILNGLGFsu+sLYLFPpFFpsKslE+LlGpGlpA-aLNDDtLGRsLDcLYchGsoplFtplAlp	.........................................................thpl.pslDHLGlVAullDclGlsclIsph.lsh-..s.p.c.p.losGpsVKAlllNGLGFss..psLYlaspFFpshshE+LlGps..lpPcaLNDDtlGRshDcLYchu.lsplF..lsh.p.............	0	43	106	116
+13947	PF14105	DUF4278		Domain of unknown function (DUF4278)	Eberhardt R	re3	Jackhmmer:A8ZNS8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 58 and 136 amino acids in length. There is a single completely conserved residue R that may be functionally important.	25.30	25.30	25.40	25.30	24.70	25.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.58	0.72	-4.02	53	145	2011-05-10 08:06:48	2011-05-10 09:06:48	1	2	71	0	65	166	197	56.30	30	62.60	CHANGED	M....cL.....sYRGlsY-.hsssslp...............sspsp............hsupYRGhsa.......hpphsh.psp...hsLp.YRGVsY	......................M..pLsYRGlsYs..s.sssp...............htpsp............lphpYRGhsY......phpphppht.s...t.hp.Lp.YRGlsY..................................................	0	5	47	58
+13948	PF14106	DUF4279		Domain of unknown function (DUF4279)	Eberhardt R	re3	Jackhmmer:B0C1A4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 134 and 145 amino acids in length.	25.00	25.00	25.60	25.40	24.70	23.40	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.23	0.71	-4.22	48	184	2011-05-10 08:13:26	2011-05-10 09:13:26	1	1	166	0	42	156	3	116.00	23	83.66	CHANGED	lhu-shs......s.-plTphlulpPopsht+Gshhpss...p......hhtphssWtlsoptttpts...lp..cplcpLlppLp....sttstlppltpphsh....p......thhshh.shssspsss....................lsschlphlsslGsplsl	.............................lhG-.hss.-tlTphLslpPTcshtKGchhtppp...........hhpppssWpls...othppshc.....lp..splphllcpLp......scpptlpclppcasl...p.........hlhhlhhp.hpssp.sPs....................lspchlphhuslsu-lch.........................................................	0	13	31	35
+13949	PF14107	DUF4280		Domain of unknown function (DUF4280)	Eberhardt R	re3	Jackhmmer:B0C1L7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 129 and 456 amino acids in length. There is a single completely conserved residue C that may be functionally important.	25.00	25.00	25.30	25.50	24.50	24.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.92	0.72	-10.90	0.72	-3.74	69	265	2011-05-10 08:22:45	2011-05-10 09:22:45	1	18	148	0	84	252	15	112.10	27	38.96	CHANGED	VssGAhlpC.shGsss...utLpVhs....ps.plhspu.....p.hAohtDhhsh.....hNlhsFG.........hCpsh..sssss..................ChPs......ss.Wt...st.sslhl...........suts.sLpssSphhCsa.G..Gh..Iplhss......GQt	.................................lstGAhlpC.shGsss...shLtlhs.....tp.ts.hhss.....................tshushtDphsh.....hNI..sFG...............................hCps...ssssht...............................................ChPs...hs.Wh..sst.ssshl...........ssts.sLspsSphhCsh..G...Gh...IphhssGQ...................	0	24	63	73
+13950	PF14108	DUF4281		Domain of unknown function (DUF4281)	Eberhardt R	re3	Jackhmmer:B0CBE6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 147 and 232 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	27.00	27.00	32.80	32.40	23.50	22.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.70	0.71	-4.04	70	170	2011-05-10 08:58:51	2011-05-10 09:58:51	1	2	128	0	92	165	946	126.70	30	64.30	CHANGED	stlFslushhslPhWhLhl........hhP...php.......hTp.plhpohh..shlhLu....hlYhhlhhsuhss...ssssh...........................hssL.s..ultplF...............usptsshsuWl.HaLshDLFVGpWlhh-upcpu.l......hhh.sLlLshhhGP.lG.LLsa	......................t..lFshushhslPhWhLMl........hhP...php.......................hTc..clhpShh..shlsLu....hlYshLlhhuhsstshthh..........................hssLs.ulsphF...............usptssssuWl.HhLshDLFlGRWlah-utc..ps......l...........hshhsLhLshhhGP.lGLLsa........................	0	45	80	89
+13951	PF14109	GldH_lipo		GldH lipoprotein	Bateman A	agb	Jackhmmer:C7PII4	Family	Members of this protein family are predicted lipoproteins, exclusive to the Bacteroidetes phylum. Proteins in this family are typically between 155 and 167 amino acids in length. Members include GldH, a protein linked to a type of rapid surface gliding motility found in certain Bacteroidetes, such as Flavobacterium johnsoniae and Cytophaga hutchinsonii [1]. Gliding motility appears closely linked to chitin utilization in the model species Flavobacterium johnsoniae. Not all Bacteroidetes with members of this protein family may have gliding motility.	27.00	27.00	27.30	27.60	26.00	22.50	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.38	0.71	-3.93	60	194	2011-05-10 08:59:56	2011-05-10 09:59:56	1	2	190	0	54	193	141	132.50	28	81.38	CHANGED	psplac.papsls..s..uWp+scslpFpl.shtDss.s.YslhlslRssssYPapNLaLllphphs..p.uph.....hsDTlphpluc.ss....GphhG.pGhus.lhppph.h....pshpFs.csGpYplplppsMRcs.......sLpGIs-VGl+l	......t.ptlYc.pYpsls..s...uWp+s-s..lpF.sl..shp..D.sh.ssYplhlslRssssYPY..pNLaLhlp.hphs....ssph......hsDTlphpLs-..ps....GphhG.pGhus.lhppph.h....psh.ph..csGsYplplppsM+cp........LpGIsDlGl+l....	0	23	48	54
+13952	PF14110	DUF4282		Domain of unknown function (DUF4282)	Eberhardt R	re3	Jackhmmer:B0CFB0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 93 and 155 amino acids in length. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	28.20	27.80	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.99	0.72	-3.79	54	193	2011-05-10 09:26:58	2011-05-10 10:26:58	1	3	179	0	82	176	29	83.40	25	68.64	CHANGED	h.hsFccalTspllphlYhlulllhslhslssl.....huuh..............................s.hhuhhtllh.uhls...hlhtllhsRlhhEhhlshh+ls-slppltcpt	...........hpF-palTPpllphlYhlsllhlslhuls..sh........hsuh.......................................hhhhl...h.uhlh....hllshlhsRlhhEhllslF+ls-sLpcItcp.s.....	0	26	54	70
+13953	PF14111	DUF4283		Domain of unknown function (DUF4283)	Coggill P	pcc	Jackhmmer:A0MDU5	Domain	This domain family is found in plants, and is approximately 100 amino acids in length. Considering the very diverse range of other domains it is associated with it is possible that this domain is a binding/guiding region.  There are two highly conserved tryptophan residues.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.61	0.71	-5.13	121	920	2011-05-10 09:46:33	2011-05-10 10:46:33	1	139	22	0	264	872	0	122.60	17	16.68	CHANGED	lplsccth.......hltp....sLl....G+a.......hs.p.......lps.ltphhtptWtLpu...plpltpl..s...p...s......hhlhcFcptt-hc+VLppGshthps.hhlhLc+W.s...spssshp.pthpph.lWVRlhsLPlphasp.phhcplGsthGt.hlplD.pstphpphp..as.....Rlh.Vc	....................................................................h.......................................................h....h.t....a.t.....t...ththh.h...t...t......s......hhhhpFpt.t-h.pplht......t...us..h.h.h..p.s.....hhl..hlp..pW.s.........t.s.....t.....t.ph.h..hWlcl..h..slP.hthhst.phhpt.lu.pthGt.hhtlD.t.s..t....h....hp....hh+lhl........................................	0	25	157	230
+13954	PF14112	DUF4284		Domain of unknown function (DUF4284)	Bateman A	agb	Jackhmmer:C7PJ13	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 124 and 142 amino acids in length.	27.00	27.00	29.30	28.00	25.40	26.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.93	0.71	-3.64	22	158	2011-05-10 12:25:39	2011-05-10 13:25:39	1	2	101	0	24	145	0	117.30	28	81.12	CHANGED	hVolWlG.sFpopp-hppYh-.........cY....-.E-ucplsSpFtp-hsltah..DcDhlEtshhsps.t............slppLLpshSYspphlpph.phh...ph..pphNslIhlYshc..Ystphcpsp............lpalGshpYc	.................VSlWlG.sh.p.oppplcpYh-l...................pY......c.--G-pl.supFhpDFsls.hh..D-D..hlEhphhpps.ps............slptLLpshS.Y.cp.pl.lsphhphh...th..pphNulIhlYsap..Ysppsppspt............hpalGshtY.............................	0	6	13	19
+13955	PF14113	DUF4285		Domain of unknown function (DUF4285)	Bateman A	agb	Jackhmmer:C7PJQ8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 157 and 206 amino acids in length.	27.00	27.00	27.70	27.60	25.90	25.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.93	0.71	-4.10	48	220	2011-05-10 12:39:33	2011-05-10 13:39:33	1	3	185	0	60	159	4	122.90	37	69.00	CHANGED	ssapNsCAl.RhShuLppsG....hshpshs.............hthhh..ss........+hhhh..RspchtsaLp..p...s.......................ssshtsplpu...............+pGIIhF...hthWspu........uG...HlsLW...NGsphs......sps..................................................shtpspplhFW	...........................................................h..apNsCsIRMSYsLNto.G....hslspto................htpluGsDs........KhYha..RVs-hhcaLp+p.......hs...........+P-hIs....................sssppuchhG...............KKGIIlh.pspGWosA........pG...HlTLW...NGohso..DpCah................................................................................	0	19	28	44
+13956	PF14114	DUF4286		Domain of unknown function (DUF4286)	Bateman A	agb	Jackhmmer:C7PK46	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 100 and 112 amino acids in length.	22.80	22.80	22.80	22.90	22.60	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.11	0.72	-3.72	46	171	2011-05-10 12:48:32	2011-05-10 13:48:32	1	2	166	0	61	159	102	97.20	30	86.20	CHANGED	IYNlThpl.-csltccWlpWh.pcpHIP-llsost...Fppuplh+llscp-ts.........GpoYolQYpscspssLppYhpcpuscLcp-shppFusKhluFc....Th.LEhl	........IYNsThpl.-cslccpaltWh.pcpaIP-lhpsGt...hpps+..ls+lLs..cc-pt.........GpsYSlQapscspssLpcahpc....puscLpp-hhchFt..c.KhluFt....Tl.hEll.................................	0	31	56	61
+13957	PF14115	YuzL		YuzL-like protein	Eberhardt R	re3	Jackhmmer:C0H3R0	Family	The YuzL-like protein family includes the B. subtilis YuzL protein Swiss:C0H3R0 which is functionally uncharacterised. This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	33.40	33.30	23.00	17.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.85	0.72	-7.92	0.72	-3.68	7	211	2011-05-10 13:53:45	2011-05-10 14:53:45	1	1	121	0	23	67	0	42.10	53	90.24	CHANGED	sKhKKsPSKsGlSAssV+Gp.GsT.pcsGuh+psStppphKKc	..KlKKsPS+uGlSAssVcGp.GsT.s+ts.u.st+.sSsNpphK+..	0	1	11	14
+13958	PF14116	YyzF		YyzF-like protein	Eberhardt R	re3	Jackhmmer:C0H3T9	Family	The YyzF-like protein family includes the B. subtilis YyzF protein Swiss:C0H3T9 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	30.60	30.20	21.20	17.50	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.37	0.72	-4.01	25	164	2011-05-10 13:59:09	2011-05-10 14:59:09	1	1	164	0	35	95	1	48.20	47	83.06	CHANGED	sCcEHlElAlDpaVD-hEpsPslpclpcsp......sppCcaC.cptApYlVs	.sChEHlElAlDhhVDEpEluPsIppl-soc....p.ppsC.-aC.pspAsYlVs..	0	11	23	28
+13959	PF14117	DUF4287		Domain of unknown function (DUF4287)	Bateman A	agb	Jackhmmer:C7PKG7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 70 and 180 amino acids in length.	27.00	27.00	27.90	27.00	24.20	23.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-8.90	0.72	-4.28	59	198	2011-05-10 14:04:37	2011-05-10 15:04:37	1	2	162	0	95	200	86	60.60	38	62.24	CHANGED	uhpoYlss.Icc+TG+slscWhpll...cpp.........sssKat-hVsWLKsEHGLGHGHAsAlVthhctp	...........u.toYhss.IEcphG+sls-Whpllcpp.........shs+ahElVuWLKsEH.GLG..HGHAsAlVshhht.t............	0	33	71	88
+13960	PF14118	YfzA		YfzA-like protein	Eberhardt R	re3	Jackhmmer:C0H3X6	Family	The YfzA-like protein family includes the B. subtilis YfzA protein Swiss:C0H3X6 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	27.00	27.00	32.60	32.50	19.60	18.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-10.23	0.72	-3.88	4	111	2011-05-10 14:05:57	2011-05-10 15:05:57	1	1	78	0	6	58	0	91.00	59	97.31	CHANGED	MssK...tpPl..hKRsWhpolssFllsQLlFIIhEhTuWhP..sF+-.Gshhs+lVsSpFFTcWFu.YcsPaFNllTlFhuIhhll.slhGAhKDlhspt...N	..........hh....K...tpPl..hhRsWh+hLGsFhlhQLlFIlsE.lTuWsP..NF+..GpFhsR....llN.S..pFFTEWFoPYKhPpFNVhTAFaAIhLl..uLluAhKDhpoRKp.........	0	2	5	5
+13961	PF14119	DUF4288		Domain of unknown function (DUF4288)	Bateman A	agb	Jackhmmer:C7PM87	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	27.00	27.00	27.60	27.00	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.91	0.72	-3.86	22	131	2011-05-10 14:09:39	2011-05-10 15:09:39	1	2	128	0	20	109	2	90.90	45	74.05	CHANGED	aYlsphlhchh..........t.psstpppshhcEphlLlcAcop....-cAac+upc.hut.ppcpsapN..p.sptlpachhsls-lh.l.h-pl-c.G....sElau	...............hYuVKLLFEol..........hspch-cs+coLFEES.IILVKAsSh....EEAHtLuEp.lAh.puEc.TYcN...hh..sEQlTWoFRKl...LcVFEL..spssFEo.G....pELYu..	0	13	19	19
+13962	PF14120	YhzD		YhzD-like protein	Eberhardt R	re3	Jackhmmer:C0H3Y1	Family	The YhzD-like protein family includes the B. subtilis YhzD protein Swiss:C0H3Y1 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved GKL sequence motif.	27.00	27.00	31.30	73.80	23.10	17.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.89	0.72	-4.07	15	141	2011-05-10 14:12:53	2011-05-10 15:12:53	1	1	141	0	23	80	0	61.00	67	97.73	CHANGED	Mp.sYhLTVF-psGEpLL-EpFEAusD-EAKchGcppLcE+shpc+THRhssu.GKLlLFHR	MG.lYVLTVFEKDGoKhLDESFEAATEcEAKsKGEuILpEKGLaEKTHRCTSoAGKLVLFpR.	0	6	15	18
+13963	PF14121	DUF4289		Domain of unknown function (DUF4289)	Bateman A	agb	Jackhmmer:C7PM99	Family	This family of membrane bet-barrel proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. Swiss:Q2S343 is identified by Gene3D as a membrane bound beta-barrel.	27.00	27.00	39.20	27.70	21.30	20.70	hmmbuild  -o /dev/null HMM SEED	614	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-12.85	0.70	-6.10	62	213	2012-10-03 17:14:37	2011-05-10 15:18:18	1	3	201	0	58	222	301	617.50	27	91.63	CHANGED	.slpsapl.s.hht-pphs..sssThpptapp.shhpt.phchhshuNlGpshpshhat.c...p.htshhhhcshchhhhps...............cclpaasshoPhTpLhYpssspp...tpphcuhauhNhsc+.......hshuhpachlhupGhYps........ptsuphN.hphhsuYhuc..RYphpstasspch.pspENGGl.ss-shhptspph.....................ppp......aps.splsspL..pps...pNp.cspchalsHcYplshpp.hsth......................................................................................................................shhHohpa-spphhapps.......t.h..psht..................h.ssshpDpTphhplpNphuls......asph.hh..utlpsahstchhp.Y.....thssh.......................hh.pphpppplslGGpl.t+p.uphhchpupu...c..htl.stshuphplpuphshsh...t-sh.pltushhh.pspsPsFhh.phapSpa..a.WpN......shsp.ppppltup..lshp+htsplpsshsp.........lcNYsYF.......................sspstspQpussIsl.LphplppcFp.hGhaph-NplhaQpsos..psl.........LslPplsshsslYhphpl...hp.KsLhlphGhsh+YFTp..YhAssYsPslupFhlQs.........phclGsaPllcsahNh+l+psRlFlthpHlNsuh.ss........sYFhsPpYPhpshhl.+FGlsWNFFs	...............................................................tlh.apl.p.hhsspphh...ssDThtpta.pp.shhpt.php..hs.huNlGsPh.shha.p+pp.......t.hhhh.psh...shhhhps...............schpahso...oPhTpLtYppuusp...ppphcuhauhNhs+c.......lshGhsachlhucGh...Yps..........ptouphN.hphauoYhuc..+Yp..hpshhsspph.cssENGGI.ss-phlspspph.................ppp...........ap.s..splsshL.sps..............tNp.cspphalspcYsLuhp+ph...s.t....tsth.........................................................................................................uhhHohph-pppppapst.....tpspsaatpshh.....................ssshpDpTphh..s.lpNphuls.........sFsph..sp....usLpuahsachhp.Y..ph.sh..............................h.pphsppplhlGGpl.sKptGphhchpspu..E...hsl....spshGphplcuphshsh.....t-ss.pltApu.h...psptPs....Fhh.ppapSpa.....ahW.cN......shspphpspltup.....ls..hp+h...tspLpsshps.........lcNYsYF..............................sppstspQpu.usIpl.lphplppcF...+.hGhap..h-Nplh..aQpoos..psl.....................LslPplsshsslYhphpl..h..KsLplphGs-s+YF.Tc..YhAs..sYsPslsp...FhlQs............phcl.Gs.Y...PllssasNh+l++.sRh.FlhhpHlNsuhhss.........sYFhsPcYPhssth.l.+hGlsWNFas..............................................	0	25	52	58
+13964	PF14122	YokU		YokU-like protein	Eberhardt R	re3	Jackhmmer:C0H434	Family	The YokU-like protein family includes the B. subtilis YokU protein Swiss:C0H434 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two conserved CXXC sequence motifs.	27.00	27.00	28.10	28.00	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.40	0.72	-10.05	0.72	-4.26	10	136	2011-05-10 14:25:58	2011-05-10 15:25:58	1	1	128	0	14	62	0	83.70	68	95.75	CHANGED	sCcWCsppcAssspsoVYWELPDGT+AIEIs-TPuIsCSuCGMsYQ--sllcEIEDQLlLIDoKKLPcslTYcpLMsp-RlLKRNYF	........................MWCDSTEAKESLNTVYWELPDGTKAIEIQ-TPCISCSSCGMDYQuDpTVKEIEDQLFLIYTKDLPKQLTYEELMuRPRLLKRNYF...................	0	2	8	10
+13965	PF14123	DUF4290		Domain of unknown function (DUF4290)	Bateman A	agb	Jackhmmer:C7PMG8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 200 and 221 amino acids in length. There are two conserved sequence motifs: EYGR and KLWD.	27.00	27.00	50.20	50.10	26.70	26.50	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.08	0.71	-5.08	48	201	2011-05-10 14:29:21	2011-05-10 15:29:21	1	1	197	0	55	186	178	174.90	47	82.69	CHANGED	L-YNTpRp+LllPEYGRplQpMV-aslslcD+-ERs+sAcsIIslM.GphpPcL.RDssDapHKLWDpLhIMSsFcLDlDsPashsscEpLtp.+P-.lsYPpsph+aRaYGpsIpphI-pAhphEcG-c+-uLlhsIANpMK+salsWNK-oV-DchIhpcLt-LScG+lpLstss.cL	......h-YNTp+c+LhlPEYGRpIQpMVDaslolpD+cERp+sApoIIslM.Gsh.PHL.RD.VsDFpH.KLWDHLtIMSsFcLDlDhPY-l.spc.-s.L.ts.+P-.lsYPpsph+YRHYG+slcphIc+Ahchp-G-c+csLlthIANaMKKsalsWN.K-o.V-DcpIhcDLt-LSsGclpLstpt..h.......................	0	24	49	55
+13966	PF14124	DUF4291		Domain of unknown function (DUF4291)	Bateman A	agb	Jackhmmer:C7PN25	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 190 and 214 amino acids in length. There are two conserved sequence motifs: VYQAY and RMTW.	27.00	27.00	49.30	38.30	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.15	0.71	-4.66	57	206	2011-05-10 14:31:31	2011-05-10 15:31:31	1	4	187	0	91	186	3	173.00	44	83.25	CHANGED	+pIRA..ta.sscTIsVYQAYsspIAcsAlpst+Fs.sP.FphsRMTWIKPSFLWMMYRuGWupK.tsQERlLAlcIpRcGF.-hhLppusLSph..............................tsthh.sptpWppplppus......................VRlQWDPERslphpsL....saRSIQlGLsschlc.cYsc-WIluIpDlTshs+clcphlpsu.....phcpAttLLPt..EcsY	...................pIRA..pa.sppTITVYQAYsssIAssAlcsG+Fs.us.Fph..sRMTW.IKPSFLWMMYRuGWutK.tsQE+lLAlcIpRpuF.-hhLppAsLSph.................................................ps.plasp.tstWcpth...ppus......................VRVQWDPERsl.php..L....taRSlQlGlssphlp.pas--.WI..VuIpDlTshs+ch+pllpsG.....chppAtthlP.Ec.Y..................	0	35	61	79
+13967	PF14125	DUF4292		Domain of unknown function (DUF4292)	Bateman A	agb	Jackhmmer	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 243 and 287 amino acids in length.	27.00	27.00	27.20	27.30	26.40	25.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.32	0.70	-11.09	0.70	-4.91	73	228	2011-05-10 14:33:12	2011-05-10 15:33:12	1	1	225	0	80	221	184	198.30	21	75.77	CHANGED	ssphcslsuchplslp..tpppp.sssssl+hc+-ctIhlSs..shlG.hpVu+hhlTP-plhhhD+lpppYhpu..saspLp....chlshs.lsFp...pLpslLlGp..hhhshppphp......hphs......sp.th.lp.pp..........sthphthhhsspshplpphpltptss...ppplphpYtsapph.....stthhPtplplth.p......ttppsplslpasc...hsh.spshphsaslPspYcpl	.................................................................................................................t...hpslsu+hplslp..sppppholsssl+hc+cchlhlol..shlt.hEluRh.lTPDplhhhD+hs+.pYhcu.......saspLp....plhshs.lsFp...pLQsLlhsp.......hhhstppphp.......................hp.t........tt.h.lp.pp.....................tthth.hhhsstphhlt..p.plt..t.st...t.tlphpYtsap.h.....stt.hPtphplth.p.......tpphplplphpp...hph...spsh...p...h.hphsptap...................................	0	33	61	76
+13968	PF14126	DUF4293		Domain of unknown function (DUF4293)	Bateman A	agb	Jackhmmer:C7PP09	Family	This family of integral membrane proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 154 amino acids in length.	27.00	27.00	27.10	29.00	25.30	24.60	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.91	0.71	-4.28	71	211	2011-05-10 14:35:41	2011-05-10 15:35:41	1	2	209	0	68	197	86	143.70	32	97.01	CHANGED	IQRIQTlYLLlssl.hssshh.hhPlhphssssthhh..t.h..h............................hhhslhhlsullulhuIFhaKpRtLQhpLsh...lshlLhl...hhhulhshhhhshtsph........hshphthuhhlPllullhhhLAt+uIp+DEcLV+usDRL	............................IQRIQTlYLLlssl.lhhshh..hhPlhphhss..shhh.....hthhsh.h....t.....................slhslhhlssllulhoIFhaKpRh........lQhplsh....hshlLhl....shhshhs.hhhhslpsph..........hshphuhuhhLPllullLhhLAh+uIt+DEtLV+usDRL......	0	25	53	65
+13969	PF14127	DUF4294		Domain of unknown function (DUF4294)	Bateman A	agb	Jackhmmer:C7PPB4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 192 and 226 amino acids in length.	27.00	27.00	83.40	82.90	23.60	23.10	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.85	0.71	-4.63	44	181	2011-05-10 14:42:30	2011-05-10 15:42:30	1	1	178	0	44	172	171	154.90	44	73.32	CHANGED	GDoIs....hlpLspVhlhsph+.Fcsc....c-cppYhhLhRcV+KVhPhAKhsscplh-htchLpolss++s+c+ahKhlcKhlcccaosclKKLThoQGplLIKLlpRQTupToY-LlKshhuGa+AhaYpshAthFshSLKccYcP..stEDhLlEcllhps	.......................tDoI...hlpL.spValas.hc.F+..sc....c-+pcYh+LlcsVKKVhPhAK.ssctllEh.caLpTlPsc+t+c+ahKpVEKtlccpYoschKKLohoQGKlLIKLIcRpospooY-LlKuahGsa+AsaYQshAtlFGsSLKccYDP..ps-DtLhEcllhh.s........	0	15	38	44
+13970	PF14128	DUF4295		Domain of unknown function (DUF4295)	Bateman A	agb	Jackhmmer:C7PPC2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There are two completely conserved residues (K and Y) that may be functionally important.	27.00	27.00	27.20	32.00	26.00	26.60	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.29	0.72	-4.34	27	189	2011-05-10 14:44:08	2011-05-10 15:44:08	1	1	188	0	52	149	49	47.70	61	93.33	CHANGED	AKKs.....VATLpput..uKphoKlIKhVKSsKTGAYsFcEchlss-pVp-al	..............AKKs.....VATL+pGp...G+saTKVIKMVKSPKTGAYsFcEpMVsNEpVpDFh.......	0	24	47	52
+13971	PF14129	DUF4296		Domain of unknown function (DUF4296)	Bateman A	agb	Jackhmmer:C7PRC6	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 90 amino acids in length.	27.00	27.00	28.00	29.60	26.30	26.10	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.82	0.72	-3.83	55	193	2011-05-10 14:45:37	2011-05-10 15:45:37	1	1	192	0	54	193	131	86.70	28	35.94	CHANGED	PcslIscccMpslLaDhaLscuhtt.........tsppptstpthshpphlacKaslssspFspShsYYspp.scphpcIYcclpcRLppcppshsp	....................PpslIspscMcslLYDhHlupuhtt.........stshspshpphthh.ptla+KaslopspF-sShhaYscp.s-hhpcIYccVpcRLcscppth..t........	0	23	48	54
+13972	PF14130	DUF4297		Domain of unknown function (DUF4297)	Bateman A	agb	Jackhmmer:C7PUH4	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is typically between 207 and 221 amino acids in length.	27.00	27.00	27.10	27.10	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.60	0.70	-11.55	0.70	-4.39	34	146	2011-05-10 14:49:40	2011-05-10 15:49:40	1	6	139	0	34	124	9	198.00	20	46.26	CHANGED	.pEpuGstutptFcaQhpaAlhpllchhpsps.shtlhhEh+-Dlslhps.t.t.sph..-ahQVKTpcss...pWohssLsch...............................pppp.............Shlu+Lhpp..pppas.stssplthVostsh...shslcshphshppt.......splpsphtpplp...pp...lpsphshsp..h.hstlhhl..hssls.Lcshppplhuplsphl..chhsp.stp.spslhctlhcplcc+us	.....................................p-puGstuhptFpaQhphAlhphhphh..p......p..ps..satlhhE...........hc...........-.Dlsltps......sph......sFhQVKspp.......pt....saoh..ps...lspp.......................................pptpt..............Shlu+Lhpp......ptpht...ptsp......c..lthlospsh........shs.cp..phphtsh.........tplppp.tpplp...pp.....................ltsphs.t...h....phlhhh....hssls..lpsh.tp..hhuphsp.h..phh.p...p.spslhp.lhpphp.+u...........................................................................................................................................................	0	13	24	29
+13973	PF14131	DUF4298		Domain of unknown function (DUF4298)	Bateman A	agb	Jackhmmer:C2M2S9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 94 and 105 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.	27.00	27.00	27.20	29.30	26.80	26.20	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.04	0.72	-4.11	25	275	2011-05-10 14:52:29	2011-05-10 15:52:29	1	1	267	0	31	183	1	85.70	29	84.60	CHANGED	+IpchpctaschpchlscLpcsl-papcshpchppLpsYY.oppWhcDhps.pps...phss.chptuVLSEDulashhu-phpLAhphLclus	..............+IpcMpphhpchsphLspLpcslpphpct..pphtpLcsaY.op-ahcshct.pps...........phss.phstuVLSEDulashhs-pppLAhphLcl.......	0	10	18	27
+13974	PF14132	DUF4299		Domain of unknown function (DUF4299)	Bateman A	agb	Jackhmmer:C2M3B8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 275 and 313 amino acids in length. There are two conserved sequence motifs: RGF and DAY. There are two completely conserved residues (P and D) that may be functionally important.	27.00	27.00	28.80	28.70	25.70	25.20	hmmbuild  -o /dev/null HMM SEED	304	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.90	0.70	-5.28	20	348	2011-05-10 14:56:01	2011-05-10 15:56:01	1	1	303	0	17	200	0	267.10	50	97.31	CHANGED	SloFaIKNK+p.hh.uhpclhoscclLsLsct..Lppauh-tsppphshpchhtt.ltp.t....sllhGspspSuRGFELuYsccppsY.sVRlhTPSopsDWplALpalpsLupph.sscIhsE.pGcpaoscsIppFDYcsDIhhGlcsl.tplpscpttsh....haGlpRPlshscchl-cIhsupss..lcpFuchlcch..QaLDAY.A+QpFacspsssc..IhGhYsLopslcTILPac..P...V-hpshphlpsc-luhWplsllshsu-csc..ptYphluplcYccFlcpLPc-KYcalDAsYIhVcsLo+-Elpcl	...........................................t.hTFaIsNKpS.lL.GpQclLsAKSILuLlDG...LESHSYDsshLRQsLN.RLp............hIcCulsGpSphhF+VSYsDup.KuY.pVclPDhhT+sDWpIlhsFLcALhuhh.Go-I...........EGL-sF..DFEAaFpuuIpsaLuD.sA+h.shCp......GIhsPlaFS+EpLcuFLcuDu...LApFEspVRsl..QpoDA..YFA+spFYpDu-.GK..VaGlYaLAQGV+TVLP+E..P....aVPss..YlEQLs-+EVp...W-IcLVpIoGDusK.PEsYEuIARLDYscFLEsLP.saY+pLDA.sQIcVQPIhsp-hcsL.......	0	4	6	11
+13975	PF14133	DUF4300		Domain of unknown function (DUF4300)	Bateman A	agb	Jackhmmer:C2M4P8	Family	This family of lipoproteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 281 and 303 amino acids in length. There are two conserved sequence motifs: NCR and PYQ.	27.00	27.00	54.40	54.20	20.00	19.90	hmmbuild  -o /dev/null HMM SEED	250	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.64	0.70	-5.11	36	333	2011-05-10 16:08:49	2011-05-10 17:08:49	1	1	320	0	24	172	0	241.20	60	83.36	CHANGED	hsYSNLssppSpcEVpshL......sAslsppslcpFhphVs-YNs.sl.....ppstlpssFssh...tps-YDh.t..IpchWpc+pss.Fh.GsNCRIouFsLhKshIpsssstp.......ssph....LFhDt-uIcss..............plhspp-cpcFpsLFopl.Tc.....sTpDlc.hHtpphpctaKphtlpF....tss+hpllSVhlHsp...-sshLFlGHsGVLlsscsG.aLFlEKluFppPYQAlKFss+p-lpc.YLhs+Ycs..htspsp.A+PFIM-NDchl	...................................u.SYoNLNspsSsEEVKSLL......SAHLDssSVDuFFNLVNDYNs.lV.....GSTGLoGDFToF...T+TEYD.VEK..IScLWspKKGD.FV.GTNCRINSYsLLKNSlTIPKlEK.........sDpL..LFlDNDAIDKG..............KlFDupDKE-FDILFSR.VPTE.....ATT.D.VK.VHA-KMEsaFSQ..FpF.....NEKARMLSVVLHD...NLDG-aLFVGHVGVLVPsDDG.aLFVEKLTFEEPYQAIKFASKEDCYK.YLuTKYsD..YTGEGL.AKPFIMDNDKWV.............	0	8	14	19
+13976	PF14134	DUF4301		Domain of unknown function (DUF4301)	Bateman A	agb	Jackhmmer:C2M610	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 505 and 516 amino acids in length.	27.00	27.00	84.20	83.60	21.10	18.40	hmmbuild  -o /dev/null HMM SEED	513	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.69	0.70	-5.95	43	177	2011-05-10 16:11:31	2011-05-10 17:11:31	1	2	172	0	47	182	62	495.50	53	98.03	CHANGED	hoppDlpQlcp.......+Glo.cplppQlchFccGhPhlpL.puAolscGIhtlsscEpcphlsha-p..tppstcllKFVPASGAAoRMFKsLapFL.............su.hscppssthppFFsslccFsFYccL.ppslpspt.slssLhsstchtt.llctLLstcGLNYGshPKGLL.FHpYs.-ts.pTP.....hEEHLsEuAhYAsss.upsclHFTVSp-HhctFcpplschtsphEpchsspacloFShQ+sSTDTlAVsh-.NpPFRsc-GpLLFRPGGHGALI-NLN-lDADllFIKNIDNVV....s-ph+pcTlpYKKlLAGlLlplQc+sFpYLchL-ps.phscpplpElhpFlpccLshph....s.phpphsppphhpaLpp+LNRPlRVCGMVKNpGEPGGGPFWltstDGslSLQIlESuQIDhssscptphhppuTHFNPVDLVCul+sY+GcpFcLhcaVDppoGFIopKS+sG+pLKALELPGLWNGAMAcWNTlFVEVPltTFNPVKTVNDLL+spHQ	...........h.oppDhc.ltp.......+GIopcplpcQLppFppGFPaLcLpuAAol.p.c.GIhshspcEpcpalstW-s.hppss+plVKFVPASGAASRMFKsLFpFL.............sAth..spPsscFccpFFssIccFAFYccLstsChc.spspslssL.htpspY.KslVssLLpspGLNYGsLPKGLLhFH+Ys.-.ss.RTP.....hEEHLsEuAhYAssp.GcsplHFTVSpEHppLFcphlscphstapc+auVcaploFSpQKPSTDTIAssh-.NpPFRstsGpLLFRPGGHGALIENLNDlDADllFIKNIDNVV....PD+LKs-TlpYKKllAGlLlsLQcpsFpYLchL-su.cho+ppltEllpFlppcLss+p....s.-hcpLp-spLshYL+pKLNRPhRVCGMVKNsGEPGGGPFhshNsDGolSLQILESSQIDhssscppchFcpuTHFNPVDLVCul+DYKGc+FcLscYVDcsTGFIS.KSKsG+-LKALELPGLWNGAMScWNTlFVEVPLsTFNPVKTVNDLLRppHQ..	0	19	41	47
+13977	PF14135	DUF4302		Domain of unknown function (DUF4302)	Bateman A	agb	Jackhmmer:C2M6D7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 344 and 443 amino acids in length. There are two completely conserved residues (R and L) that may be functionally important.	27.00	27.00	40.70	33.90	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.64	0.70	-4.99	51	186	2011-05-10 16:14:32	2011-05-10 17:14:32	1	2	93	0	30	178	0	240.70	24	56.39	CHANGED	-p-sl.F-c..osupRlspslpphpclL...uutsG.WhhpYYssps..........................aGG.ashhhKFsssp.Vshtu-hs.........sssppssShYplppspu.shLoFDTYN.h.....lHhhupPsssts........pGhpGDa..EFll.....hpsss-..plhlc.......G++stNphhhs....htpstshppahsphppsppthp....hstaphhh...............sspphshthpspppthhhs..hsssp......hphsahhTspG.l.phhpPl....plsGhp.hpphsaspssp	............p-sl.F-c..osupRhppslpchpchL..psuspG.WhhpYasp.ss..........................hGG.ashhhKFsssp.Vshtu-hs..........ssssthsSpYplp.pspu.shLoFsTYN..h.....lHhhusPpttts............tGhtuDa..EFll.....hssss-..plhlc.......G+Kptsphhhs....htpshshcph...hpp.ht.s.hppshp......hhhhphhh.................sspths.hhh.ps.p..t.pthhhs.......hssss.............hshsahhTp...pG....l.p.........hh.pPl.......plsGhp...hppasaspt..p................	0	20	27	30
+13978	PF14136	DUF4303		Domain of unknown function (DUF4303)	Bateman A	agb	Jackhmmer:C2M6J2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 169 and 192 amino acids in length.	21.60	21.60	21.80	21.60	21.30	20.90	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.89	0.71	-4.58	38	181	2011-05-10 16:15:50	2011-05-10 17:15:50	1	3	156	0	39	155	8	149.60	23	79.57	CHANGED	ltpAs+psapplhp..cpss-shYuauLhosspuhs..lssuAsoc-sLptttp........p..pst..h.........................+Wsss-Wsa...t.sttphFsplsphltphscphp.p.t...........apphhptlhpshlsuLppLcpcGlFust...tph.hlhlslsss-sspt.....ppsctLNss	.....................................................lhpuhpptapplhp..cp.ss-shYua...u...l...h.....oDsssts...lsssANocchlph.pts.........cs...shh...........................+auss.EWsh.......hssht...hFscl...schlpp.h.pphhpps.................aphhhp..plhpthlpsLhcLcp-Gl.Fust....sc..hlhlslsDsssp.hh....ppsphLNs.h..............................................................................	0	6	20	27
+13979	PF14137	DUF4304		Domain of unknown function (DUF4304)	Bateman A	agb	Jackhmmer:C2M6R4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 223 amino acids in length.	22.50	22.50	22.70	22.50	21.70	21.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.38	0.71	-10.55	0.71	-3.98	48	164	2011-05-10 16:19:06	2011-05-10 17:19:06	1	1	144	0	38	153	4	111.30	17	58.01	CHANGED	lsshLKptGFpK.pshsaa+.pppphhtllshQ+sph.........thpFhlNlGlhshthsp................................ph.pthshthpt...Rluslhspt..............s.haplcspp.shp.thhppltp.......tlpphllsah	...................tthL+.hGFpp..pt.s..ah+.pppshhhhlshQ+Sph.................sspFhls..lGlhshtltp..............................................................tt..pp.s..hhhts......+lstlh.pp................hapl..stt....sht.hhtpl.t........lpt.hh..........................................................	0	13	27	31
+13980	PF14138	COX16		Cytochrome c oxidase assembly protein COX16	Bateman A	agb	Jackhmmer:Q5ACH7	Family	This family represents homologues of COX16 [1] which has been shown to be involved in assembly of cytochrome oxidase [2]. Protein in this family are typically between 106 and 134 amino acids in length.	27.00	27.00	27.70	27.70	25.60	26.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.58	0.72	-3.81	52	253	2011-05-10 16:50:56	2011-05-10 17:50:56	1	11	223	0	174	242	0	79.60	35	58.69	CHANGED	lhaGLPFlhhlVuGSasL..pphoplRY-hpcpKspph.sppEthsht..............pp++cl..slc-E.Yh+l...psh.sh-.........sWE.hRl.R.htE	................lhaGlPhlhllVuGSFsL..ppho.tlRY-ttcpKscp..spc-ththt...............................tpp+cl.....slc-E.Yh............+l....pst..sh-.............................sWEphRl.R.ht-.................	0	47	90	140
+13981	PF14139	YpzG		YpzG-like protein	Eberhardt R	re3	Jackhmmer:C0H444	Family	The YpzG-like protein family includes the B. subtilis YpzG protein Swiss:C0H444 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a conserved QVNG sequence motif.	27.00	27.00	32.20	38.50	17.40	16.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.56	0.72	-4.03	8	104	2011-05-11 07:19:52	2011-05-11 08:19:52	1	1	104	0	17	34	0	49.80	68	98.29	CHANGED	MGp..p+cpaDp...p.YSsPFspPWsNPKHA+uQVNGcTQQoQsLIILcspsRK+p	.......MS...YRDRLDs.....RSELFNHTWTRPKHAKAQVNGQTQQTQSLIILANECKKRQ.	0	3	11	12
+13982	PF14140	YpzI		YpzI-like protein	Eberhardt R	re3	Jackhmmer:C0H446	Family	The YpzI-like protein family includes the B. subtilis YpzI protein Swiss:C0H446 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	27.00	27.00	32.40	58.00	26.20	16.40	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.38	0.72	-8.08	0.72	-4.46	8	121	2011-05-11 07:34:23	2011-05-11 08:34:23	1	1	121	0	13	41	0	41.90	80	91.57	CHANGED	MGKDRQEKKLKtS+RVESDRDQSLpYsGATpL-oPEcARKRN	MGKDRQERKLRESRRVESDRDQSLQYPGATuLDTPEQARKQN..	0	1	8	10
+13983	PF14141	YqzM		YqzM-like protein	Eberhardt R	re3	Jackhmmer:C0H453	Family	The YqzM-like protein family includes the B. subtilis YqzM protein Swiss:C0H453 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length.	27.00	27.00	33.70	33.60	26.70	25.90	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.09	0.72	-4.17	11	134	2011-05-11 07:51:06	2011-05-11 08:51:06	1	1	134	0	22	49	0	42.90	79	95.72	CHANGED	NcFE.KDVQsKRNDAlDSuVGFlVSFGFFsslFlIAslIcFlGp	...NDFE.QNVQSKRNDAIDSGVGFIVSFGFFATLFIIATVIKFIGS...	0	6	15	18
+13984	PF14142	YrzO		YrzO-like protein	Eberhardt R	re3	Jackhmmer:C0H458	Family	The YrzO-like protein family includes the B. subtilis YrzO protein Swiss:C0H458 which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	100.90	100.80	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.23	0.72	-4.32	2	83	2011-05-11 07:57:22	2011-05-11 08:57:22	1	1	82	0	4	18	0	46.00	90	99.79	CHANGED	MhEuLLFFhusGlsCELAAINRNGRKpIKQQAEhIQlLKE.h.KsI	MLESLLFFFAVGVACELAAINRNGRKKIKQQAEhIQLLKELKER.......	0	1	2	2
+13985	PF14143	YrhC		YrhC-like protein	Eberhardt R	re3	Jackhmmer:O05395	Family	The YrhC-like protein family includes the B. subtilis YrhC protein Swiss:O05395 which is functionally uncharacterised. YrhC is on the same operon as the MccA and MccB genes, which are involved in the conversion of methionine to cysteine.  Expression of this operon is repressed in the presence of sulphate or cysteine [1]. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	35.80	35.70	25.40	21.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.36	0.72	-4.03	17	134	2011-05-11 08:20:14	2011-05-11 09:20:14	1	1	132	0	19	88	0	71.80	56	89.73	CHANGED	pcLcsKhtDYKpFuhlLLAlSsFLYlGslIP.tuhpsspp.hhhsulslhLshuhhhh+RuhhhpcpLcEt-	...KELppKIEDYoRFGQlLLAVSThLMlGLLIPsGuKEThQhFlMMGoIVIFLuLSFFFFpRVKlhRccLEEsE......	0	2	11	13
+13986	PF14144	DOG1		Seed dormancy control	Coggill P	pcc	Jackhmmer:Q9SN45	Family	This family of plant proteins appears to be a highly specific controller seed dormancy.	27.00	27.00	28.30	27.60	26.40	26.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.77	0.72	-3.94	81	488	2011-05-11 10:20:54	2011-05-11 11:20:54	1	7	52	0	217	469	0	77.90	41	23.87	CHANGED	+plsEL....Rs.ALpup.h...........sDs-L+hlV-sshsHY.pclachKusA...A+sDVF...al.lSGhWpoPsER.sFLWlGGFRPS-Ll+lLhsp	.............................+phsELRsAlpu+h...........sDs-LRh.lV-sshsHY.sclF.chKusA...A+sDVF...al.loGhWpoPuER.sFlWlGGFRPS-ll+llhs.......	0	28	122	175
+13987	PF14145	YrhK		YrhK-like protein	Eberhardt R	re3	Jackhmmer:O05401	Family	The YrhK-like protein family includes the B. subtilis YrhK protein Swiss:O05401 which is functionally uncharacterised.  Its expression is under the control of the motility sigma factor sigma-D [1].  This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length.	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-9.07	0.72	-4.30	57	199	2011-05-11 10:48:16	2011-05-11 11:48:16	1	4	174	0	77	175	13	60.00	30	54.02	CHANGED	hppY-hhth......................lsDhhsulhFllGSlhFhhs.s...ht............hsusWlFllGSlhhhl+Psl+ll+cl+	..................p.ppYchlth............hsDhlhulhFllGSlhFhhc.t...ht........................phGsahFllGSlhhhl+Phl+llpph.h............	1	33	54	71
+13988	PF14146	DUF4305		Domain of unknown function (DUF4305)	Eberhardt R	re3	Jackhmmer:O05524	Family	This family includes the B. subtilis YdiK protein Swiss:O05524, which is functionally uncharacterised.  This is not a homologue of E. coli YdiK, which belongs to Pfam:PF01594.  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	27.80	27.80	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.61	0.72	-4.21	20	171	2011-05-11 11:57:29	2011-05-11 12:57:29	1	1	170	0	24	78	0	37.10	43	60.72	CHANGED	llFsYhAlpsss-ss..WshaThllhlhAshDFshul+hl	.hlFTahAlssVsDsh..WshaTILhhlMAshDFslulRLI.	0	6	15	18
+13989	PF14147	Spore_YhaL		Sporulation protein YhaL	Eberhardt R	re3	Jackhmmer:O07520	Family	This family of proteins is involved in sporulation. In B. subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E [1].	27.00	27.00	52.80	52.70	25.70	21.50	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.60	0.72	-4.52	10	131	2011-05-11 12:12:26	2011-05-11 13:12:26	1	1	131	0	20	58	0	49.50	70	76.14	CHANGED	hPWWVYhlIlGIlFSuYMsl+ouKEE+EhDQcaIE+EGclYMcRlEcERE+R	....hPWWVYLVIlGIlhSGYMVLYTSKKEQ-MDNEFIEKEGEVYMKRLcEEREKR..	0	3	12	14
+13990	PF14148	YhdB		YhdB-like protein	Bateman A	re3	Jackhmmer:O07530	Family	The YhdB-like protein family includes the B. subtilis YhdB protein Swiss:O07530, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 57 and 82 amino acids in length. There are two conserved sequence motifs: LMVRT and FLHAY.	27.00	27.00	74.10	74.00	22.50	21.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.76	0.72	-4.23	6	132	2011-05-11 12:24:37	2011-05-11 13:24:37	1	1	131	0	16	43	0	69.50	71	93.88	CHANGED	Ms.hsDYDKALYYTaRSpWDsLLILMVRTKDDLLSKRIE+FLHAYpFp+Das.V-KpL.sLLpYIDHA..hoshpppEt	...p.h.DYD+ALYYTapspWDpLLlLMVQTsDQLFSKRIEHFLHAYQYSKELPEVDKQLQLLFQYIDHASQKSHlEElE.Q.......	0	1	8	10
+13991	PF14149	YhfH		YhfH-like protein	Eberhardt R	re3	Jackhmmer:O07606	Family	The YhfH-like protein family includes the B. subtilis YhfH protein Swiss:O07606, which is functionally uncharacterised. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response [1].  This family of proteins is found in bacteria. Proteins in this family are typically between 42 and 53 amino acids in length.	27.00	27.00	27.00	30.00	26.90	25.10	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-7.99	0.72	-4.16	17	140	2011-05-11 12:36:23	2011-05-11 13:36:23	1	1	127	0	25	77	0	36.90	66	75.72	CHANGED	lpphsEFFRNLPsKpCscCGcc.I-EQpEsYtspC-cC	............-pshEFFRNLPoKsCAcCGKE.IDEQHEuYpNcCDDC	0	8	19	22
+13992	PF14150	YesK		YesK-like protein	Eberhardt R	re3	Jackhmmer:O31514	Family	The YesK-like protein family includes the B. subtilis YesK protein Swiss:O31514, which is functionally uncharacterised.  Its expression is regulated by the sporulation-specific sigma factor sigma-E [1].  This family of proteins is found in bacteria. Proteins in this family are approximately 100 amino acids in length.	25.00	25.00	26.60	26.20	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.69	0.72	-3.88	10	127	2011-05-11 12:48:56	2011-05-11 13:48:56	1	1	108	0	12	74	0	76.40	57	81.94	CHANGED	FallGhlohlllFslShll+++aPsKp.h-hlLuhlLIllslhslhlSlFllGGWEGhGlGlluhhlllGolIGhIActhl+	........FYIIGGlTIlLVFAIS..YLLKKRFPDKQ..FDIIFALuLILLCLAoFPVTMhlIGGWEGMGYGFIGFFVLLGTLIGMIAHQLlK........	0	1	8	8
+13993	PF14151	YfhD		YfhD-like protein	Eberhardt R	re3	Jackhmmer:O31572	Family	The YfhD-like protein family includes the B. subtilis YfhD protein Swiss:O31572, which is functionally uncharacterised.  Its expression is regulated by the sporulation-specific sigma factor sigma-F [1].  This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	27.00	38.20	26.50	26.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.11	0.72	-3.86	16	145	2011-05-11 12:59:37	2011-05-11 13:59:37	1	1	141	0	27	79	0	54.30	55	99.03	CHANGED	MsRsptpKs+cK.NctphsQsPct....uDuhDVEFSpElADp-DhEApsRupAADtRt........pppcp	........................................scpph.p.sKs......oDGlDVEFS+ELADHsDLEApARAsAADsRQK...p....sp........	0	4	17	19
+13994	PF14152	YfhE		YfhE-like protein	Bateman A	re3	Jackhmmer:O31573	Family	The YfhE-like protein family includes the B. subtilis YfhE protein Swiss:O31573, which is functionally uncharacterised.  Its expression may be regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins [1].  This family of proteins is found in bacteria. Proteins in this family are approximately 40 amino acids in length. There is a conserved QEV sequence motif.	27.00	27.00	36.90	36.50	19.80	18.50	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.15	0.72	-7.75	0.72	-4.05	13	126	2011-05-11 13:10:06	2011-05-11 14:10:06	1	1	124	0	15	42	0	36.60	66	92.22	CHANGED	-.....K++pccs+soLopsQEVpYup-FKtAD+A..u..pt++	............DKKKRDKsKNsLSSTQEVLYQREF+KADRA..AGYRuKS.........	0	2	8	10
+13995	PF14153	Spore_coat_CotO		Spore coat protein CotO	Eberhardt R	re3	Jackhmmer:O31622	Family	Bacillus spores are protected by a protein shell consisting of over 50 different polypeptides, known as the coat.  This family of proteins has an important morphogenetic role in coat assembly, it is involved in the assembly of at least 5 different coat proteins including CotB, CotG, CotS, CotSA and CotW. It is likely to act at a late stage of coat assembly [1].	35.00	35.00	43.30	40.20	34.00	33.70	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.20	0.71	-4.85	16	142	2011-05-11 14:03:18	2011-05-11 15:03:18	1	2	126	0	22	123	0	159.60	42	98.69	CHANGED	s+cph.....scpcPLLYIsQPchpc.spspMQcsaht+pcppp..................ttppptppp...................p........p..t....t...p..p..t..tppttppp..........................................................h.hcKsFpcMsl-EKIsFLsphPcplPslpCplhocpcoYcGllhshcss...plhltss......tpt..spsplsh-cIhSlphlGF	...............................................ps..Ks.p..sssKPLLYIsQssh-h.ussphpcIllsphcscs....................pcEppscscph......t...pth.E.ppppt..............pcp.tp..p..tp.p.p..ppppc.s.......................................................psh.hpKsF+-Ms.-EKIcFLhshPHalP+l+CcIcTsshoYhGsIluhRNG...hVsIhss......ssh..c-hcLuI--IpSIsMhGF........	0	1	11	14
+13996	PF14154	DUF4306		Domain of unknown function (DUF4306)	Eberhardt R	re3	Jackhmmer:O31651	Family	This family includes the B. subtilis YjdJ protein Swiss:O05524, which is functionally uncharacterised.  This is not a homologue of E. coli YjdJ, which belongs to Pfam:PF00583.  This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 95 and 152 amino acids in length.	27.00	27.00	44.90	44.30	21.40	21.20	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-9.90	0.72	-4.01	8	123	2011-05-11 14:12:19	2011-05-11 15:12:19	1	2	99	0	11	90	0	87.50	47	78.91	CHANGED	hlQaGhuhhlFlFSAlsoWYpGSpLlsssa-WKaoshFophh.G..slss.cpISQLDaFlYAAKapPshsslMllShlYlLsLlhhhlhp	.....hlQhu.uhhlFlhSAL.ho.WYQGSsLl-sP.EWKYoAKFTshhp.G..TVoshcDIYQIDFFlYAAKFYPsshIVMllSlLYhLlLIlahlh.........	0	1	5	7
+13997	PF14155	DUF4307		Domain of unknown function (DUF4307)	Bateman A	agb	Jackhmmer:C7PZ49	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 132 and 153 amino acids in length. There is a single completely conserved residue C that may be functionally important.	27.00	27.00	38.70	52.60	25.50	23.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.34	0.71	-4.28	57	347	2011-05-11 14:48:55	2011-05-11 15:48:55	1	1	343	0	86	210	61	112.00	31	78.09	CHANGED	pscpthhslsslhslsuhshhuh..hsapphusssl..suphluacllsDs.psplphpVs+s.s..upsuhChVcAhspctuEVGRc-lhl....ss......ssppphchssslcTsp.ussuclh.GC	......tcthhhlll.hVLsllhhshhsh...huhp.h.us..ssl..puplhGaphl...sD.s.pssVTlpVpRsDP..ShsusChVpAput-tuEVGR+-lhl...Ps..........ussps.plpssV+Tpp.uVsu-lhuC...	0	26	65	82
+13998	PF14156	AbbA_antirepres		Antirepressor AbbA	Eberhardt R	re3	Jackhmmer:O31697	Family	This family inactivates the repressor AbrB, which represses genes switched on during the transition from the exponential to the stationary phase of growth.  It binds to AbrB and prevents it from binding to DNA [1].	27.00	27.00	54.50	54.40	23.20	21.30	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.05	0.72	-4.32	6	115	2011-05-11 14:58:50	2011-05-11 15:58:50	1	1	115	0	12	35	0	61.00	70	96.46	CHANGED	Mp+cls...LTpEEppLLLDILFpQpYAhElLusELsDIEsGhKpsDhppY++lsRLasRL+sE	.Mp+EhV...LTcEEESLLLDILFQQNYASEILAVELTDIENGLKpTDVhQYKKITRLFYRLKNK.	0	1	4	6
+13999	PF14157	YmzC		YmzC-like protein	Eberhardt R	re3	Jackhmmer:O31797	Family	The YmzC-like protein family includes the B. subtilis YmzC protein Swiss:O31797, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 58 and 91 amino acids in length. There is a conserved ELR sequence motif.	27.00	27.00	35.10	34.60	25.60	20.60	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-8.97	0.72	-4.15	7	102	2011-05-11 15:18:03	2011-05-11 16:18:03	1	1	94	6	6	68	0	58.60	57	69.31	CHANGED	hNpEpllEh.ssas.....os.psppssMsQltcNpFAlh.......-csplKIa+as.cTNclpLlKEass-E	......spEpsVEh.ssas.....Ss..hsTssMTQlu-NTFAhp......sEsspIKIFKFNPDTNEIKLIKEFhusE...	0	1	3	3
+14000	PF14158	YndJ		YndJ-like protein	Eberhardt R	re3	Jackhmmer:O31813	Family	The YndJ-like protein family includes the B. subtilis YndJ protein Swiss:O31813, which is functionally uncharacterised. This family is found in bacteria and archaea, and is typically between 222 and 269 amino acids in length. There are two completely conserved G residues that may be functionally important.	27.00	27.00	42.30	41.70	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.69	0.70	-5.33	14	139	2011-05-11 15:24:24	2011-05-11 16:24:24	1	2	133	0	21	118	0	248.50	55	50.67	CHANGED	shssspthlhLusLhhlPhshphh.pts......h..shhh+....h.PluAlsAshuhshs.....tshhAssWhshsshhAlhussRl.......hpRshc....hpElulsuullYlssGuhWhhstsuslslhtFu..IlhLTAsHFHauuFshPlhsGLLGRt.t.......tct.hlaphhshhIhluPhh.lAlGIshSchh-hhushlhssAlhuhuhhshtps......hcspsuthLltluuhsLhholshuhhYuhGphhupshl.sIspMlhhHGssNAhuV	...........slsslEAIlLLSlLLFlPhohsllDKcs....RsGu.llFYK.VShLYPIAAIsAhLAFVTs.......thhFAllWFlYTGl.....lAL...FGlsRL.......................LERGh+P.................LEEsAIDSAFIYLFLGGFWFFASVA+lo.IMpFSsDIlLLTAAHFHYSAFLLPLSAGLlG.RK+c............KpS..KlYcsIhalIhISPMT.VAIGITYSRl.....FEFFAVhLYLsAIYuYuh.YVW+s+......FsuloAKILLllSSoTLMlTIhFSLIYSYGNh+pVhTI.TIAQMVWIHGVVNGlGV.......	0	7	14	18
+14001	PF14159	CAAD	DUF4308;	CAAD domains of cyanobacterial aminoacyl-tRNA synthetase	Bateman A	agb	Jackhmmer:B1XK71	Domain	This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids [1]. aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative transmembrane helices and is present in glutamyl-, isoleucyl-, leucyl-, and valyl-tRNA synthetases, the latter of which has probably recruited the domain more than once during evolution.	27.00	27.00	27.70	27.70	25.70	26.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.78	0.72	-4.34	96	289	2011-05-11 16:33:04	2011-05-11 17:33:04	1	7	100	0	141	276	113	86.30	31	38.78	CHANGED	lspl.pthsph..sphphshhshuhhhh.llslhlssullsAIsplPLlsslh....ELlGluYosWFsaRhLlhppsRp-Lhpclp..................shcpp.....lhG	........................h..pl.phhsph..sphphhhhssuh....llulhlssullsAIsplPLlPsl.h....ELVGlG..YouWFsaRaLlhppsRc-Lhsclp...............sl+pplhG........................	0	22	85	123
+14002	PF14160	FAM110_C		Centrosome-associated C terminus	Coggill P	pcc	Jackhmmer:Q8TC76	Family	This is the C-terminus of a family of proteins that colocalise with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.	21.00	21.00	22.10	23.30	20.00	17.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.67	0.71	-3.13	16	181	2011-05-11 17:01:40	2011-05-11 18:01:40	1	2	70	0	114	169	0	111.10	43	28.84	CHANGED	p+.psuLpRSKS..DlSc.RaStutu-lE+FFsaCGLDsp.l-tLGh.-shtpss....S..DhsSl.phcSsossuS-.s......tpopcSs.-.sh.............pE-tts-RlP.GlSlIERNARVIKWLYup+pA+	.................................s.psuLpRSKS..DLSs.Rauc.....shu-lERFFsaCGLDPEtl-sLG.h...EpF.upus...................S..DhsSl....shpSsossoS-.s..............tpSpc.Ss..s.sh........................................t--...pst-RV.....P....u.lSllERNARlIKWLYuh+pA+..........	1	14	22	61
+14003	PF14161	FAM110_N		Centrosome-associated N terminus	Coggill P	pcc	Jackhmmer:Q8TC76	Family	This is the N-terminus of a family of proteins that colocalise with the centrosome/microtubule organisation centre in interphase and at the spindle poles in mitosis.	22.20	22.20	22.20	22.20	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.39	0.72	-3.79	5	153	2011-05-11 17:02:04	2011-05-11 18:02:04	1	2	49	0	93	142	0	103.50	38	31.34	CHANGED	s.uK....PluPAGPh.ouAVPLRILNKGP-YF.R.RQA..EssP+RhSAVERLEADKAKYVKSQEVINAKQEPVK..PPVLt.KPhsSPu.....PKRuu....uoP....ohKApss.puKo-SG.u......+RsNLcL	.....................................hs...ssshP.hRlhsKsP...s..Yh..R...R.s...-..s...s..s..+..+.....hSAVERLEADKAKYVKSppVlss+QE.P.Vp.....sslht..pP..hsss......spt.sh.........tP.....sh+..........................................................................................	0	8	16	47
+14004	PF14162	YozD		YozD-like protein	Eberhardt R	re3	Jackhmmer:O31863	Family	The YozD-like protein family includes the B. subtilis YozD protein Swiss:O31863, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	92.00	91.90	23.60	17.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.32	0.72	-8.75	0.72	-3.89	6	127	2011-05-12 07:20:28	2011-05-12 08:20:28	1	1	127	0	15	38	0	56.90	81	96.98	CHANGED	MKEIEVVIDTEEIAEFFYpELlRRGYVPoE-ElEElADITF-YLlEKChIDEEh---	.MKEIEVVIDTEEIAEFFYEQLIERGYVPKREEIEDLADITFEYLLEKCMIDEVFDEE..	0	1	7	9
+14005	PF14163	SieB		Superinfection exclusion protein B	Eberhardt R	re3	Jackhmmer:O31930	Family	This family includes superinfection exclusion proteins. These proteins prevent the growth of superinfecting phage which are insensitive to repression. It aborts lytic development of superinfecting phage [1-3].	26.00	26.00	26.10	26.10	25.90	25.30	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.42	0.71	-4.64	34	252	2011-05-12 07:43:39	2011-05-12 08:43:39	1	1	226	0	34	153	4	143.90	25	82.81	CHANGED	hhhhLslhsuhLL....hhPpshlphlslsphhsp...at.alGlshllusAallspllshh....hp.hhph......hpp++phctlccp.....lptLsspE+slLppahhps..pphlpLshssssVpsLhppsIlphhust........ssttphplshphpsahpcpltphspt	.................hahllIhhh..hll....lhPsshhphlsltp..hh....t.ahahlllhslSallstslsph.......hcthh.t........pp+ptpcphtph.......hpsL..o.tE..pAlL.t.hltss...p.l....ph.pssPhshpLhc+Gllp+hsss........sspstahIs-papp.hhhthtsc...t.......................................	0	8	16	23
+14006	PF14164	YqzH		YqzH-like protein	Eberhardt R	re3	Jackhmmer:O32014	Family	The YqzH-like protein family includes the B. subtilis YqzH protein Swiss:O32014, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	27.80	40.00	23.90	20.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-9.00	0.72	-4.06	9	119	2011-05-12 07:53:05	2011-05-12 08:53:05	1	1	119	0	12	63	0	60.80	59	94.71	CHANGED	MsEKhIcKhltpshcQYu.s.pshPlosp-hcpLhcpIppthspcs-hDlYEhlcDlVY-YlTu	.MNEKLIEKMIIKSFQQY....QCsPlSpEDQEMLlKHIQslhHSNscIDlYEtlEDIVYDYVTG.	0	2	4	6
+14007	PF14165	YtzH		YtzH-like protein	Eberhardt R	re3	Jackhmmer:O32066	Family	The YtzH-like protein family includes the B. subtilis YtzH protein Swiss:O32066, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There is a conserved DIL sequence motif.	27.00	27.00	38.30	71.50	20.90	18.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.80	0.72	-3.75	14	132	2011-05-12 07:58:12	2011-05-12 08:58:12	1	1	132	0	21	51	0	86.70	69	94.45	CHANGED	LsppHQLsLL+DILssHpsDCsGTVuEsEQlERLlpSLhsNssl.ssslKslLpcI....YsYuQsGh.utslssHIstppppLspWlssls	..INQQHQLEVLKDILlNHQSDCCGTVSECEQLERLIQSLLANDsI.SSDsKsMLNDV....YSYSQSGKSSSNLDNHISNNQEQLTQWIuGMD.	0	4	13	15
+14008	PF14166	YueH		YueH-like protein	Eberhardt R	re3	Jackhmmer:O32093	Family	The YueH-like protein family includes the B. subtilis YueH protein Swiss:O32093, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	38.30	38.00	26.70	23.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.72	0.72	-4.22	17	252	2011-05-12 08:07:03	2011-05-12 09:07:03	1	1	252	0	16	76	0	75.00	57	93.12	CHANGED	KI...chhptps.hhsVYlaEscccp.hllAIPslpWShplshp.-ppplt-cLhhpLhphh-EppAppLAsplspWlpc	......hl....NKRhlDEGKTIDVYLFEulNsQ.IIIAIPDWFWSYQMAMTL....DEETCFEAILMQLF..VFKEEEEAESIASQLTDWIET...	0	2	5	12
+14009	PF14167	YfkD		YfkD-like protein	Eberhardt R	re3	Jackhmmer:O34579	Family	The YfkD-like protein family includes the B. subtilis YfkD protein Swiss:O34579, which is functionally uncharacterised.  Its expression is regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins, and by the forespore-specific sigma factor sigma-G [1,2]. This family of proteins is found in bacteria. Proteins in this family are typically between 254 and 265 amino acids in length.	27.00	27.00	29.90	29.60	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.59	0.70	-5.29	10	138	2011-05-12 08:22:59	2011-05-12 09:22:59	1	1	137	0	20	94	0	229.10	72	89.47	CHANGED	PsSVlsISKENTYPNPTQDLPhLQPS-LAcpLL-oo-VKIENP-LIRhLNESSIsuoPLAIGYRAoIYLGpWPLsYESsETssNWEYQKVNTNhlDNRGGpuspplpYpQEpQK+V+GGLTAcIPNu--VKKMMLlKAtEKTsLPLAFcTVIGtGTKK-psYsVsPK+lGYLauYsPAVNEKGKVTYGEVYLsLKGsK++LsVKNVTpQGIGAWIPVQD+lSFuFhsSspP+	.....PSSVLNISKDNTaPN-AQDLPRLQPSKFAQELLKTANIKIENPDLIRMFNETTISNAPLAVGYRAKIYLGQWALpYESlDTSlNWEYKQVNRNVYDNRGGD+LYPLRYKQEoQKTVEGsLTAchKcAsDVKKMMLLKAhEKVQLPLSFKTTIGYGTG+ERVYNISPsQLGYLYAYTPAVNEKGKVTFGEVYLVLKGNQK+LVVKNlTSQGIGAuIPIpDHLaFKFlSSS+s.p.............................	0	3	12	14
+14010	PF14168	YjzC		YjzC-like protein	Eberhardt R	re3	Jackhmmer:O34585	Family	The YjzC-like protein family includes the B. subtilis YjzC protein Swiss:O34585, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	25.00	25.00	25.30	25.20	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.60	0.72	-4.04	20	212	2011-05-12 09:55:35	2011-05-12 10:55:35	1	1	206	0	28	102	0	56.70	51	92.41	CHANGED	M......G............p.....pp.F+PGp+APNsGhYl.ElGt.pGut..VpsP+pVclctGD+FP-ToN+sR..+Wpp.+	..............MGppppF+sGpKA.PNs.GlY.....V.ElG-.sGuh....Vp.sPphlpLstG-+FP-To..N+sR..tWph......	0	8	18	20
+14011	PF14169	YdjO		Cold-inducible protein YdjO	Eberhardt R	re3	Jackhmmer:O34759	Family	This family includes the B. subtilis YdjO protein Swiss:O34759, which is functionally uncharacterised. This is not a homologue of E. coli YdjO, Swiss:P76210.  B. subtilis YdjO is cold-inducible [1]. Its expression is induced by the extracytoplasmic function sigma factor sigma-W [2].  This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length.	27.00	27.00	28.10	30.90	24.00	26.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.35	0.72	-4.52	15	173	2011-05-12 10:24:33	2011-05-12 11:24:33	1	2	128	0	30	85	0	59.30	52	59.05	CHANGED	MYapK+spEslPcEp...TsVWpCouEDCpGWMRcNFoh--pPhCPLCpSsMhsupRhLspl	........h.RKpshtplP.Ep.....TsVWECpuEDChGWMR......KNF.........o.........a......EEc..........PpCPLC+SsMpsGpRhLPpL..	0	8	19	20
+14013	PF14171	SpoIISA_toxin		Toxin SpoIISA, type II toxin-antitoxin system	Eberhardt R	re3	Jackhmmer:O34853	Family	SpoIISA is a toxin which causes lysis of vegetatively growing cells.  It forms part of a type II toxin-antitoxin system, where the SpoIISB protein, Pfam:PF14185, acts as an antitoxin. It is a transmembrane protein, with a cytoplasmic domain accounting for approximately two-thirds of the protein. The structure of the cytoplasmic domain resembles that of the GAF domains, Pfam: PF01590. SpoIISB binds to the cytoplasmic domain of SpoIISA with high affinity [1].	27.00	27.00	32.30	32.20	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.41	0.70	-5.11	7	118	2011-05-12 10:56:17	2011-05-12 11:56:17	1	1	113	2	13	77	0	239.80	59	97.97	CHANGED	lLFFQhhV..........WlllhuLhlY.VaAsWRaEtplcE+hhsIRKTWYhLaVhGuslaWTa-PpSlFTcWpcYLIlAVhFsllDAFIFLouYlpKluusE..hpTDTcpllEcNs-hL+hhhs+LKsaphLLKs-sIHlY....YGoh-AYhpGlccllttaA-KhslpAulh.assptsKDcLhcp..................hcpptslpscLsRp-VYYpppsKlVlIP.FolpsppaVlKLoS-sllTEFDhLLhsSLssIYDLlhs	...............NIRIG.......l..........FlLAIVFlVL.VF..FYW+NEELYEEKKQRI...RKTWYGLFIlSVTVYFMIKGID.LTLWKNLLMFTAMVIFVDIAFILTPNISEIWGAK....FSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPuVFGT..MEWHTEEEYTKSLNsFLDSYGEKIGAKIVVFEAAKELNTN..F.Rsh+sp.............................FSh.IlPlEaIEQLNEQ+AV..QVENVGIIP.AKIV.SDVFIVI.D...GKKNNLQDRDFENVYNLTIHHSYFS.K....	0	2	8	9
+14014	PF14172	DUF4309		Domain of unknown function (DUF4309)	Eberhardt R	re3	Jackhmmer:O34960	Family	This family includes the B. subtilis YjgB protein Swiss:O34960, which is functionally uncharacterised. This is not a homologue of E. coli YjgB, Swiss: P27250. Expression of B. subtilis YjgB is regulated by the alternative transcription factor sigma-B [1]. This family is found in bacteria, and is approximately 140 amino acids in length.	25.00	25.00	25.10	25.00	24.60	24.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.63	0.71	-4.18	15	166	2011-05-12 12:03:59	2011-05-12 13:03:59	1	4	156	0	29	141	1	131.10	44	57.89	CHANGED	hlpslhchAhcGclss..ssFslspushpDVp+phGcP-psshsusuhshYtsatu.hsluFGasKsspIhElRSFssslc......ulTlpclcptlGpPspshTs....sc-pIh.....sY+sGppYcLcFVassssst......lDHlSlh	.......h.lcsla-hAccGK..VP.N..ssFuspTusI--lcKsWGKs-+s-tuusu..hY.Aoass..+slsFG.aNKGuQlF-lRSacscLK.............uITLp-lcKsLGcPsplpss............uc-cIY.....VY+..lss....paEL+FlIscoTup..................lcHlSVh.............	0	10	22	22
+14015	PF14173	ComGG		ComG operon protein 7	Eberhardt R	re3	Jackhmmer:P25959	Family	This family is required for DNA-binding during transformation of competent bacterial cells [1].	25.00	25.00	25.30	25.00	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.89	0.72	-3.78	18	125	2011-05-12 12:37:24	2011-05-12 13:37:24	1	1	125	0	20	93	0	94.30	38	78.36	CHANGED	hahsEpphhpppcphhch-pLlphulh-lppclt...pspptpssphpa.cGplsa.phscps.tshhplslpspsssGhphsspFhhshtspcIhc.WpE	............hhs-KpFhpEhEQpalh-ELLppulssl.K+-Lp.......pcEK.csshhFpYc+GcsSh.pashEs...-hIhVsLQCphK.ppshYpVsFpYc+KcpKIh-WlE..........	0	4	12	14
+14016	PF14174	YycC		YycC-like protein	Eberhardt R	re3	Jackhmmer:P37481	Family	The YycC-like protein family includes the B. subtilis YycC protein Swiss:P37481, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length. There is a conserved HIL sequence motif.	27.00	27.00	28.70	64.30	22.30	21.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.66	0.72	-4.29	13	148	2011-05-12 12:50:22	2011-05-12 13:50:22	1	1	148	0	26	62	0	49.30	75	97.51	CHANGED	MRPLQISsETAl+LucpLsVPLEplMHMPpHILlQKlhEL.................ptppppcccs	.MRPLQISPDTAV+LSKALGVPLEQLMHMPQHILlQKLlEL.............EKpNK-.......-E.........	0	6	15	18
+14017	PF14175	YaaC		YaaC-like Protein	Eberhardt R	re3	Jackhmmer:P37526	Family	The YaaC-like protein family includes the B. subtilis YaaC protein Swiss:P37526, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 320 and 333 amino acids in length.	27.00	27.00	32.80	30.40	20.30	24.10	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.04	0.70	-5.47	27	147	2011-05-12 13:03:11	2011-05-12 14:03:11	1	2	139	0	32	142	3	284.50	38	91.65	CHANGED	hpplthapohphsppaLtppapp..htpspppuhpss.shlaalcpupsaYctuptu.slpl+PlLLaYGhhpLlKAhLLstssshs.....pposlluHGloo+cp+cpsaphhpc......cV+lpcs...G...laschscplh.......thpthpsEc........ashtcLLtpIPElppha........ptpphh.lclthhppp.......hhhspphhsphp...hstpcFhphhpppppthh.........ppppcpthhhp.s........................hp.hhstslhhphpstpaal.h...tpsthhplPplhhHYLlLYsLShlsRYcs-hWt-LLpup.spchshIppFLshstcphPhhltphl	............................WppLshFhSsppsQcaLtcsYpc..shppuccpSacNshsFlYaLcHucsaYchhphu.PhsIpPhLLFYGhsQLhKACLLThDPsYP.....psToVLAHGVTTRKRKKQsYpFh-D......EVKlQ+N...G...LFsHhucpLF...................phcplpsE+........asMhcLhtpIPELpslF......hhppctthhhclpp.ppp.......lshs.pllcph+...MoppRFscYlpp.hpth...............tcppppplhFpss.pt.......................hpshhssslhach.sspYalPh....+s..t.hLPElllHYLLLYNLSMIuRYET-WWh-LLt.uasSc.-YshIhpFLslotpKhPhhlsphl........................	0	10	22	26
+14018	PF14176	YxiJ		YxiJ-like protein	Eberhardt R	re3	Jackhmmer:P42320	Family	The YxiJ-like protein family includes the B. subtilis YxiJ protein Swiss:P42320, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	27.00	27.00	31.00	36.50	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.43	0.72	-3.93	8	95	2011-05-12 13:10:07	2011-05-12 14:10:07	1	1	90	0	7	61	1	103.30	58	87.22	CHANGED	lpELc.+hp..LcpPFPscslp+lp.sh........-ssshssDFhpaaslluGSLSYVLss..K+IPcpQh+hLcKSFFEhYPQYc.LcscItpY.cLacclpsaEcTRcLLlt	.......FpELQ.KM+SPLaKPFPspshpKlp+DhpshF....TEDDCIsADhNaYWMHTAGTLSYVLNNNEQcIsFpQIKWL+KSFFEWFPQYpFLETEIhcYPILYRDFhsYEKTRKLLLY.....	0	2	6	6
+14019	PF14177	YkyB		YkyB-like protein	Eberhardt R	re3	Jackhmmer:P42430	Family	The YkyB-like protein family includes the B. subtilis YkyB protein Swiss:P42430, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length. There are two conserved sequence motifs: NRHAKTA and HLG.	27.00	27.00	28.50	27.50	19.50	21.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.83	0.71	-4.04	9	140	2011-05-12 13:17:39	2011-05-12 14:17:39	1	1	137	0	20	74	0	135.60	65	88.32	CHANGED	Tl-NLupAlFTVNRHAKTAhNP+aLYhLKK+AlpKLlcEGKA+KlGLHFSpNP+aSQQpSDVLVplGs......YaFHlPPsKcDFcpLPHLGsLspSaRNP+s+MsLspAKpLLppYsGhKpc..pss+...ppppYpKPsa++LG-	........s.IspLAQuIFlVNRHAKAATNPKYLYhLKKpALE+LIs.EcKAlKEGLH...FSR.NPRFS..QQQSDVLI+LGD......YFFHIPPTKEDF+hLPHLG+LE..SS..YRNPK..TTLSLTlAKKsLQ-YlG.cshc.ppp+..scss.............hh............	0	1	11	14
+14020	PF14178	YppF		YppF-like protein	Eberhardt R	re3	Jackhmmer:P50834	Family	The YppF-like protein family includes the B. subtilis YppF protein Swiss:P50834, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There is a conserved LLDF sequence motif.	24.70	24.70	24.70	43.70	23.80	24.60	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-8.73	0.72	-4.44	9	125	2011-05-12 13:26:50	2011-05-12 14:26:50	1	1	123	0	15	45	0	59.80	62	92.84	CHANGED	Msls-L+ppFhphKpYpPtshNELLDFAR+hYlcGcIsIs-YRsLl+ELEtsGAspPspp	MVLGDLKQAFSQKKGYtTENsNELLDFARHhYLEGKICISDYRTlIKELEINGATKPTT.h...	0	1	6	9
+14021	PF14179	YppG		YppG-like protein	Eberhardt R	re3	Jackhmmer:P50835	Family	The YppG-like protein family includes the B. subtilis YppG protein Swiss:P50835, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 115 and 181 amino acids in length. There are two completely conserved residues (F and G) that may be functionally important.	27.00	27.00	28.90	38.40	22.20	21.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.93	0.71	-3.47	18	134	2011-05-12 13:35:43	2011-05-12 14:35:43	1	1	133	0	20	101	0	128.70	55	86.65	CHANGED	psaptsh.sahP.t...........................tp.pPYhp.s.pt...............................tPs.s.p.Ptttph..h.s..h....pPY.Pp.ps.h..p.P....sphpShhuQFKsp-Gs..aDhNKMhsTsGQhhsssN.......QVuullKGlsuhFK	..........................................p.tsYh..p.......................................................Q.pQPYhspt........t...................................hP..s.sPYsNQQuMFYPP.K............QPY.PTtsKQK....QQQP.....SQFSSFVSQFKsSDGN..YDVNKMMNTAGQMMNAMNQVTGIVKQVGGFF.u.......	0	3	13	15
+14023	PF14181	YqfQ		YqfQ-like protein	Eberhardt R	re3	Jackhmmer:P54474	Family	The YqfQ-like protein family includes the B. subtilis YqfQ protein Swiss:P54474, also known as VrrA, which is functionally uncharacterised.  This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 237 amino acids in length. There are two conserved sequence motifs: QYGP and PKLY.	27.00	27.00	27.20	29.10	23.30	26.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.35	0.71	-4.20	17	138	2011-05-12 13:47:31	2011-05-12 14:47:31	1	1	131	0	22	119	0	165.80	41	84.95	CHANGED	tGhLu+Lhstu..............thtu........................................................uuusts.suussuu...htshhs..slosMLsNlQKsLulAQpVsPM...VQQYGPLlRNLPuMh+l...a+pLssucs....tsppsspcssspppppp..t.psppppcpccph.pspppctppcppsst.p.......................SpPKLYl	..........................................tGhLu+hh.tt...........s.pthtu...................................................................htssts+GuAsss.....AuuSuGhGuhhuNLhS..N..sosMlNNlpKV.pVsQoVuPh...VpQYGPlhRNLPSllKI...hpthpSscp......spEspsEchoEpsEstossss........ppKc++KKhl.csshc+ph.c.psspphs......................oKPKLYl.....................................	0	4	14	16
+14024	PF14182	YgaB		YgaB-like protein	Eberhardt R	re3	Jackhmmer:P71080	Family	The YgaB-like protein family includes the B. subtilis YgaB protein Swiss:P71080, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	27.00	27.00	37.50	37.20	24.10	23.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-9.79	0.72	-3.74	11	129	2011-05-12 13:57:44	2011-05-12 14:57:44	1	1	129	0	14	60	0	78.00	63	90.65	CHANGED	pF-+LVuEQhcTMDcLLpLQSELERCQpIE+pLhchpccscLpsIppEIppp+ccL+pIQchFpKQTEpVIpSYppp.....Eh	............DFDKLVGEQLETMDELLKLQuHLEKYQQIEhsE+-pCDKKELHFIRQEIYRTElALKhLHEKFEcQTNsVIQSFcTEK.h...	0	1	6	8
+14025	PF14183	YwpF		YwpF-like protein	Eberhardt R	re3	Jackhmmer:P94588	Family	The YwpF-like protein family includes the B. subtilis YwpF protein Swiss:P94588, which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 146 and 167 amino acids in length. There is a conserved IIN sequence motif.	27.00	27.00	52.20	129.70	23.70	22.30	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.57	0.71	-10.57	0.71	-4.45	21	269	2011-05-12 14:41:30	2011-05-12 15:41:30	1	1	269	0	30	86	0	132.30	70	88.58	CHANGED	KTFKLlsLpll...pcpt.....php-hsLhDGLIINKEcupspWLlEsllsppatshFcphhppppplplpVsIT+tsN-PAthhssV+sIscl...scplSVLh-Gpllpp+.pshuEplLcsLlcEGlsG-pLlcp.FKpph	..KTFKAVRFQIV...NEHG.....RIIEYELEDGVIINKE-SGTGWLLEIVISNEHYETFKEYQDNEQLLDIRVVITRPANDPALF-oTVKSIKNF...KTTMSIVFECHIY.TLR.QQYAESLLEQLIDDGLSGEELKKoFNRMM...	0	7	17	26
+14026	PF14184	YrvL		Regulatory protein YrvL	Eberhardt R	re3	Jackhmmer:Q7WY71	Family	YrvL prevents expression and activity of the YrvI sigma factor. It may function as an anti-sigma factor [1,2]	27.00	27.00	27.40	27.20	22.70	21.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.77	0.71	-4.36	16	154	2011-05-12 15:00:41	2011-05-12 16:00:41	1	1	131	0	16	108	1	118.50	39	91.84	CHANGED	htphhhlhlhhslhhhllhuhhhhshsulFplhGhpYpShsullLFhllhhlL...uhhl-hht+sllpslhph.hhsphhhhlLhhhl-hhhsahslahsDpahcSlplsshsclllulhhallshhhsp..............cpp	............h..hhhlh.hhhlhlhllFuh.hFFlhhGlFplhGlpYpShsuLLLFhLlhhhL....shhh....hh+hllhshtpt..hsphlslhL..hull-lhhsWhsIHhAD-aI-SVplSshsElslsLhhalLsKhhsc.....c.....ct.........	0	5	9	11
+14027	PF14185	SpoIISB_antitox		Antitoxin SpoIISB, type II toxin-antitoxin system 	Eberhardt R	re3	Jackhmmer:O34800	Family	Members of this family act as antitoxins. They bind to the SpoIISA toxin, Pfam:PF14171. They are disordered proteins which adopt structure only when bound to SpoIISA [1].	27.00	27.00	48.60	48.40	24.20	23.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.84	0.72	-4.22	5	24	2011-05-12 15:08:58	2011-05-12 16:08:58	1	1	24	2	5	17	0	55.60	70	98.31	CHANGED	MEpAFQscpps.++tpPFKhlKK+SpTSlAcYcVSPHTcRIFKcNERLIDEYKpKKA	..........MEpAFQNspp..+tAKPFKhhKKRSpTSlASYQVSPHTARIFKENERLIDcYKpKKA.	0	1	2	3
+14028	PF14186	Aida_C2		Cytoskeletal adhesion	Coggill P	pcc	Zhang D, Aravind L	Domain	This is the C-terminal domain of the axin-interacting protein family, and is a distinct version of the C2 domain. This domain is critical for interactions with cytoskeletal in the context of cellular adhesion points [2].	25.00	25.00	40.30	27.90	23.70	22.10	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.66	0.71	-4.95	11	105	2012-10-10 12:23:49	2011-05-12 16:14:55	1	12	62	3	71	90	0	136.50	53	24.73	CHANGED	uohhPshsppsGsstLslhI-+lu.lKDAspahsPahoVoVhDssGpslpssQ-TPlu..pp+sssalhFs.sslplQsslcchsc.GuAlhhEF+HYKsKK+KhSs+CWuFMEhD-l+sG....ssslElYtKPTDh+R.KKlpLlotKshaL+lphp	.......................................uoLlPtlsppPGhThLol+IEKIG.LKDAuph..ID..PahTVS.VKDhsGhDLsssQDTPVA....s++E-sYlaFs.sslclQ+pl....EKLsK.GAA.IFFEFKHYKPK..KRhTSTK...........CFAFMEM..DEIKsG............PlVIELYKKPTDFKR..KKLpLLTcKPLYLHLp.o..............................................	0	20	28	43
+14029	PF14187	DUF4310		Domain of unknown function (DUF4310)	Eberhardt R	re3	Jackhmmer:B0P5U5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 214 and 231 amino acids in length.	27.00	27.00	29.30	29.30	19.60	18.80	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.47	0.70	-4.83	9	318	2011-05-13 07:18:32	2011-05-13 08:18:32	1	2	315	0	37	122	2	207.80	80	95.54	CHANGED	ppp+sFWaADWoFPlhVulhuAulFAGTHMYhsYGlGAFNElAlVAMLcAGlssGsYGAAAAFGASFLFARILEGsLVGILDlGGSl.TGlGlGlPAlLLuuGhstslsNFsLSLlTGuVlGLlIGhlIIhlRKhTlsQusSTaGADlMMGAGNsoGRFLGPLIILSAhsASIPlGIGShlGAAlFYhacKPIAGGAILGAMlhGulFPl	..cpsKuFWYADWSFPIFVGLLSuGVFAGTHMYYLYGlGAFNEVAFVAMLKAGhDTGsYGAVAAFGASFLFARIIEGSLVGILDIGGAIQTGVGLGVPALLLGAGhlaPVuNFhASLlTGLVlGLAIGYIIILARKFTINQSsSTYGADVMMGAGNsSGRFLGPLIILSAhoASIPIGlGSLlGALLFYIWpKPITGGAILGAMILGuIFPl.........	0	4	9	23
+14030	PF14188	DUF4311		Domain of unknown function (DUF4311)	Eberhardt R	re3	Jackhmmer:B0P5U6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 260 amino acids in length.	27.00	27.00	98.70	98.40	23.00	22.70	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.23	0.70	-4.83	9	329	2011-05-13 07:36:43	2011-05-13 08:36:43	1	1	314	0	38	136	0	202.20	82	82.56	CHANGED	ARMFHAPssQuMGAFRTLGELNACpGDPhSHFSFGLGFhFNAWASsVGAGAhTQDVpHRIIPNWAAAsLLhKNKsVpETL+DPKKMuIuGAlIGslVVshLNsTAuuIPESLQslAscVLVPAANhLINsVMPIlFWLAAlDAGK+TGhWGTlhGGLupLIMGNAVPGlVLGILIGKGVD-SGWN+lTKsMhsslllLFllSGFFRGFDhpLl	......ARMFHAPTTQGMGAFRTLGELNSCEGDPASHFSFGLGFFFNAWASSVAAGuFTQDVDHRIIPNWuAAALhlKNRNVu-TLHDPKKMAIAsAlIGMlVVsFLNhTASuVPEALQVTAVKVLVPAANlLVNhVMPVIFWLAAIDAGK+SGFWATlFGGhAQLIMGNAVPGLVLGILIGKGVEESGWN+VTKlMMsAIVLLFVLSGFFRGFDhKMI.......................	0	4	9	24
+14031	PF14189	DUF4312		Domain of unknown function (DUF4312)	Eberhardt R	re3	Jackhmmer:B0P5U7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 99 and 118 amino acids in length.	27.00	27.00	60.20	59.90	18.70	16.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.53	0.72	-4.15	20	309	2011-05-13 07:57:18	2011-05-13 08:57:18	1	1	308	0	38	108	1	84.80	62	80.17	CHANGED	phspoVpVsGKGcoKpcAFAsALuplQ+pVl+ssspllLRIEPh-VpllcAcEpspsEKFLFFFhPRcRppYpVcL-loVsVThI	....phTTTVpVpGKG-sKs+AFAsALNcVQssVh+E.oshlLLRIEPpDVcIlQA+EsVppEtFLFFFL.RcR+oYuVEL-VTVsVTAI..	0	4	9	23
+14032	PF14190	DUF4313		Domain of unknown function (DUF4313)	Eberhardt R	re3	Jackhmmer:B0P650	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 136 and 171 amino acids in length.	27.00	27.00	28.00	34.50	22.30	19.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.20	0.72	-4.32	20	120	2011-05-13 08:28:26	2011-05-13 09:28:26	1	1	84	0	7	94	5	103.80	32	61.26	CHANGED	lpLpVssYhssss....LhItLhpp-...psphEsausLTVNLsshh.....spAFIsssss.c-hhpFlpcppLucsoGhptpSGaspYsthtFshc+LpcLDP-GhpcYtcphs	......hhlspYhsNst....LhlsLhs.c....tp.E.assLTVNLsshss.....sscuFlssNps..s-hhcFlpcNcLucso.....Ghpt+SGaspYshhhFslscLtchsPcshpchttt.s.....	0	2	7	7
+14033	PF14191	YodL		YodL-like	Eberhardt R	re3	Jackhmmer:B0P785	Family	The YodL-like protein family includes the B. subtilis YodL protein Swiss:O30472, which is functionally uncharacterised. This domain family is found in bacteria, and is approximately 100 amino acids in length. There are two completely conserved residues (Y and D) that may be functionally important.	24.00	24.00	25.10	24.50	23.10	22.60	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.38	0.72	-3.53	50	285	2011-05-13 08:42:40	2011-05-13 09:42:40	1	22	147	0	33	244	34	101.40	33	14.67	CHANGED	tcsasIYQL+t..tscstsh+Fhsh-pLpppGh......pschpsYchVYsutlp........spsLEslap+FNhc+.P.tDacGHSLSlSDllhLppsGcsosaYVD.shGFpplstFh	.......................t.csauIYQlpt...spstsh+F.sh-tLpttsh......plctpsYclVYsusLs.........spsL.Ecl...appFNl..c+..P.tD........acG+SLSVSDlVslcp..sG.c..sosaY.l.D.ohGFpplstF..............	0	20	28	29
+14034	PF14192	DUF4314		Domain of unknown function (DUF4314)	Eberhardt R	re3	Jackhmmer:B0P797	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is typically between 56 and 93 amino acids in length.	24.00	24.00	24.30	24.40	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.42	0.72	-3.74	61	138	2011-05-13 08:50:07	2011-05-13 09:50:07	1	4	85	0	31	127	2	97.20	22	44.82	CHANGED	stGoRshLht...................hs.....cs.t.h.tusp..........................................usl.tVD....................Dhupl................p....................sh........hDs.GpuL............sll.Gc-hhphl	........................................ssRshhhh...................hs..........ss.t.ltpt.sh....................................................usl.sV-....t..hhssht....t..sttpl................p............................hh..h..st.hDs.Gpuh............tl..Gp.hhph.........................	0	22	28	31
+14035	PF14193	DUF4315		Domain of unknown function (DUF4315)	Eberhardt R	re3	Jackhmmer:B0P8U3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length.	27.00	27.00	27.20	27.20	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-9.83	0.72	-4.06	19	219	2011-05-13 09:28:17	2011-05-13 10:28:17	1	1	101	0	16	153	27	84.00	38	94.37	CHANGED	sKlcKlptEI-Ks+pKIsEhQu.......+L+ELEppKTEhENLEIVplVRuhsho.p-LsshLpth.........uGpssPtst.......ppc-ttcEc	.....sKl-+Icp-IcKs+...cKIsEhQp.......+L+pLEspKsEtENl-IVphVRuh+hoPppLsAhLpsh...................shtssPtsps.t....ppEcp....t..................................	0	11	16	16
+14036	PF14194	Cys_rich_VLP		Cysteine-rich VLP	Eberhardt R	re3	Jackhmmer:B0P8U5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. It contains 6 conserved cysteines and a conserved VLP sequence motif.	27.00	27.00	29.30	29.30	22.90	21.90	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.02	0.72	-4.23	20	192	2011-05-13 09:48:24	2011-05-13 10:48:24	1	3	84	0	20	140	9	54.90	55	41.26	CHANGED	TtpQ+++lptLl+phCsNY.Ds..GNCLhLD-G-spsCsQsIS.aSlhC+YFRpAVLPtD	.......tQp+psppLl+tpCCNYDs..GNClhLDDG.-sCsCsQoIS.aSlh..C+WFRtAVLPhD..	0	11	20	20
+14037	PF14195	DUF4316		Domain of unknown function (DUF4316)	Eberhardt R	re3	Jackhmmer:B0P8U6	Family	This domain is functionally uncharacterised. This domain is found in bacteria, and is typically between 56 and 95 amino acids in length.	25.00	25.00	25.20	25.20	24.40	24.70	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.70	0.72	-3.90	15	205	2011-05-13 10:04:25	2011-05-13 11:04:25	1	13	99	0	14	169	30	83.90	37	10.96	CHANGED	+pNPLKsAElohE...QNYNMlDGllNN....sPsh.....................................s--KPSlhD+LKpspp+pcu+c....................ccEp	......-NsLKsAEhshE...pNYNMIDGlINN.....tsPohs-lEtt.pt..................................................................tt.pttp.ccKsSlhcpL+stpcpppp.+p.......s..ppp.....p............................................................................	0	9	14	14
+14038	PF14196	ATC_hydrolase		L-2-amino-thiazoline-4-carboxylic acid hydrolase	Eberhardt R	re3	Jackhmmer:B0P9R4	Family	This family of enzymes catalyses the conversion of L-2-amino-delta2-thiazoline-4-carboxylic acid (L-ATC) to N-carbamoyl-L-cysteine [1]. It cleaves the carbon-sulphur bond in the ring structure of L-ATC to produce N-carbamoyl-L-cysteine [2].	25.50	25.50	25.60	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.26	0.71	-3.81	62	369	2011-05-13 10:27:15	2011-05-13 11:27:15	1	8	272	0	100	357	53	152.10	18	73.90	CHANGED	lt+cth.............................hpAthhthlhcpht.cchup..cpuppll.pcAlpphut....ttGps.httph.t.....ssshp.sFts.hhhshtpssshc...chhc..........tscschthchpcCshscha+chGh..pphthhhCch....Dtshspuas....slc.hp+spTlscGsspCcFpa	............................................................................tththht.......................A.hhh...hhctht..cphs....ppspthh...tculp.t.huh.........ptucp..hstt..t...........pshp..patp...ht...htht..t..s..ts.hc.....chhp..........ssc..p..p..hthchpcCshschh+chGh....tcht.hhCph....Dt.shhpsht.........slp.h.p.R....s....pT.lu.p.G.sspC-apa...................................	0	56	76	86
+14039	PF14197	Cep57_CLD_2		Centrosome localisation domain of PPC89 	Wood V, Coggill P	pcc	Jackhmmer:Q10218	Family	The N-terminal region of the fission yeast spindle pole body protein PPC89 has low similarity to the human Cep57 protein. The CLD or centrosome localisation domain of Cep57 and PPC89 is found at the N-terminus. This region localises to the centrosome internally to gamma-tubulin, suggesting that it is either on both centrioles or on a centromatrix component. This N-terminal region can also multimerise with the N-terminus of other Cep57 molecules.  The C-terminal part, Family Cep57_MT_bd, Pfam:PF06657, is the microtubule-binding region of Cep57 and PPC89.	27.00	27.00	27.60	27.60	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.10	0.72	-4.03	24	78	2011-05-13 10:39:40	2011-05-13 11:39:40	1	5	64	0	67	80	0	72.30	30	8.30	CHANGED	p+L-upp.sL..ps+L.DhhpR+sphp-....tthKpLsp...ERDtshppLus.Ah.csp-L+sE.-sLcpE...........Lcpph.tp	....cLEsphtsL..Qs+LDphsR+sssp-....tp.cpLsp...ERDpshppLs..AhtcspcL+pEh-sLppE...........Lcphp......................	0	13	34	55
+14040	PF14198	TnpV		Transposon-encoded protein TnpV	Eberhardt R	re3	Jackhmmer:B0PBU6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 114 and 125 amino acids in length.	27.00	27.00	27.10	28.20	26.10	26.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.24	0.72	-4.17	56	477	2011-05-13 13:11:50	2011-05-13 14:11:50	1	2	167	0	34	365	68	101.40	42	88.22	CHANGED	sYphhGD.Y...........alPsLp..lsc-pc....sl............G+YGch++pYL+Ea+sshYspLllsGcLhp+Ls-l-cpAp-ph-hllpQhtcppGlTEpLKspspMcWVppMNsl+spAEEIVhpEll	....................................pYh..GD.Y...........hlPsLplsppcp....sl..............GtaGph+ppYL+ca.+.shYspLlhoGc.LhsaLs-lscpAp-Rh-tllcpMtptpGl...T.EpLKspstMcWVtphNsI+spAEEIVhpElI...........	0	17	30	33
+14041	PF14199	DUF4317		Domain of unknown function (DUF4317)	Eberhardt R	re3	Jackhmmer:B0PBX6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 225 and 451 amino acids in length. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	36.80	27.90	21.50	26.40	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.04	0.70	-5.67	45	203	2011-05-13 13:17:54	2011-05-13 14:17:54	1	2	155	0	33	197	9	334.90	34	95.75	CHANGED	M...N......KK-lsEI.+KpF+.-s..ssIo+lsGCYVst-.+-lhpphp-sFlsLp-EEh.KYLpIFKKsLSGolGcNLl-lcFsh..................cp-tpuupQphLhpL+pSpLcD-..thl-cFYc+lIcsYsY.ssNalIllh+ssYDlPsKssDs.pph.DsS-EVY..caILCoICPVpLsKsuLsYptp-NphcsRh...pDWlVpsPptGFLFPAFsDRusDlaslLYYo+csc-.c.cFlEplLGsshshTAt-QK-sFpsIlc-slG--sch..-slpslaEpLschIE-pc.t.....psEP.htLspp-lcclLppSGVs--ph-ph-psac-shss.......................csshhAsNll...soKplcl.........................................................................................................................................cT.DlslpVsPc+schVcophID.G++CLlItl..s-psplNGls	.....MNKK-lhEl.++..paphsp...ssho+lsGCYVct-.pphhtphppsFhpLsp-Eh.K..YlclhKKsLoGslspNLhchpFsh..................pppttsup.....QphLhpL+pSpLc--....tLh-pFYcpll.-sY..pa.s..........tsahIllhHstYDlPsKssDs.tph.-.tS-EVY..callCulCPVpls+.uLta..tppphtsch....shhlphPt.GFlFPuFpDRssDlpplhYYoppspp.p.phh-phLsst....oAttpKtsFptllpcshupc.ph..chhhpl.-plsph..l-ppp.......p.-s..hLs.pplpplLtpuGl.p..htph-ptatp.h.t.......................p...hApslh...ss+phph................................................................................................................................ps.sl.lplpPpc.h..lcp.hlc.GpchllI.l..s-psplsGh........................	0	20	32	33
+14042	PF14200	RicinB_lectin_2		Ricin-type beta-trefoil lectin domain-like	Coggill P	pcc	Jackhmmer:Q8X123	Domain	\N	35.10	35.10	35.10	35.10	35.00	35.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.72	0.72	-3.66	49	1501	2012-10-02 19:42:32	2011-05-13 14:20:14	1	251	412	51	644	2662	47	100.70	22	25.03	CHANGED	ssQpWphp....h....s..........ss.....t.......aplh...ss..s....o....uphLssss.ss.tpustltth.s.s.......sssppWplps.ss..s..G..t.apl.hsh...ss.s....h.sLc.lts.s.s.ss......susslhhaph...ts.ss...sQpWphp	..........................................t.............................su........h...........a.p.lh...st..t.....o.....GpsL...sl..ss..ss....s..s...sGs.p.l...tta.ssss......sssQpWpl.....ss....su..............s....G.....h...apl.tst........so.s.......................hsLD...lts..u..u..ss........sGs.s..lh.as......ss...ss.....sQpWph......................................	0	285	489	608
+14043	PF14201	DUF4318		Domain of unknown function (DUF4318)	Eberhardt R	re3	Jackhmmer:B0PDG9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. There is a single completely conserved residue F that may be functionally important.	27.00	27.00	27.30	27.50	25.30	24.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.37	0.72	-4.15	13	131	2011-05-13 13:28:57	2011-05-13 14:28:57	1	1	104	0	4	69	0	70.70	52	79.81	CHANGED	+KuFhI-L-DuhpYPoscsICpAlEpYstcsppslcFlu+scPl.hhl-sshYElcl...phuRGsYa.lpC+El	..........pKSFFIELDDuLTYPSuEs........IsoAIEpYssEsNEpL+FESKsKPIhFYL-ss.hYcsEl...+MARG.GYY.ISCpEV...........	0	1	3	3
+14044	PF14202	TnpW		Transposon-encoded protein TnpW	Eberhardt R	re3	Jackhmmer:Q9L782	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 54 and 75 amino acids in length. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	26.90	26.30	24.00	23.60	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.21	0.72	-7.44	0.72	-4.36	31	347	2011-05-13 13:45:03	2011-05-13 14:45:03	1	2	153	0	30	225	25	36.90	36	58.15	CHANGED	sshp++IGpTTYhVplpFscsupEThpDKlpRllcs-	.....hhpp+IGposahVplaFscsus-ThpDKlt+llctE.........	0	16	28	28
+14045	PF14203	DUF4319		Domain of unknown function (DUF4319)	Eberhardt R	re3	Jackhmmer:B0PDI8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 70 amino acids in length. There are two completely conserved residues (E and K) that may be functionally important.	27.00	27.00	27.30	35.90	22.70	25.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.64	0.72	-8.85	0.72	-4.43	27	181	2011-05-13 14:14:01	2011-05-13 15:14:01	1	1	81	1	7	129	22	64.30	37	90.68	CHANGED	pFTlEEpNLhslYps.uoRpphIcslpth.hsah...Ds-.....MtpLsppslsKLpshoDsEaspLplhss	.......pFThEEhNLhslYss.......uoRpslI-slpth.hs..h....-s-......hRcLsspslsKLpuMTDu-FucLplhs..............	0	4	7	7
+14046	PF14204	Ribosomal_L18_c		Ribosomal L18 C-terminal region	Coggill P	pcc	Jackhmmer:Q9FL18	Domain	This domain is the C-terminal end of ribosomal L18/L5 proteins.	23.00	23.00	23.10	24.20	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.23	0.72	-3.43	90	635	2011-05-13 14:31:27	2011-05-13 15:31:27	1	8	464	10	360	612	6	87.50	41	31.06	CHANGED	AEshRcaIaGtHVA-YMcpLpE-D-EpY+pQFSpYIK..pGlsADslEchYpcAHtAIR......tDPsh.ccpp...........pcph.hpp....K+apppKLThcpR+pRVtpK	..........AEshRcaIhGtHVA-YMctLtE-...D..E......EtY+cQFSpYIc...pulss-sl.E-hYccAHsAIR......ts.Psh.ctp.......................pc.p.h...pp..........K+apt.Klohtp++s+ltt.........................................................	0	121	192	283
+14047	PF14205	Cys_rich_KTR		Cysteine-rich KTR	Eberhardt R	re3	Jackhmmer:B0PDJ5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are approximately 60 amino acids in length. There are 4 conserved cysteines and a conserved KTR sequence motif.	24.50	24.50	25.00	24.90	24.00	23.60	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.82	0.72	-4.51	23	165	2011-05-13 14:39:52	2011-05-13 15:39:52	1	3	119	0	10	88	7	52.00	56	84.28	CHANGED	pscWlLCPlCGNKTRsKIRcDTlLcNFPLYCPKCKQEsLIsVcpLpIoVIKEP...DA	.......t.WlhCPlCGsKTRlKIRcDT.L+NFPLaC..PKC+pEsLIclc.phcloVIpEPDA.........	0	7	9	9
+14048	PF14206	Cys_rich_CPCC		Cysteine-rich CPCC	Eberhardt R	re3	Jackhmmer:B0PDW3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses.  Proteins in this family are typically between 68 and 104 amino acids in length. There are six conserved cysteines and a conserved CPCC sequence motif.	24.50	24.50	24.90	25.00	24.30	23.20	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.02	0.72	-4.42	25	243	2011-05-13 14:50:38	2011-05-13 15:50:38	1	7	210	0	43	194	2	68.40	37	67.44	CHANGED	patCPCCGYhTlspcsst...a-ICslCFWEDDslphpss-ht.uGuN.clSLp-ApcNFtcaGAC-pchhph.VRpPts.--h	................hpCPCCGhhThp..s..........a-ICslCaWEsDsh............t.tps........s.................h........t..uGsN.phoLpcA+pNahthts...................h..................................	0	15	33	40
+14049	PF14207	DpnD-PcfM		DpnD/PcfM-like protein	Eberhardt R	re3	Jackhmmer:B0PE77	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 57 and 153 amino acids in length. There are two completely conserved residues (E and A) that may be functionally important.	25.00	25.00	26.80	26.10	24.00	23.10	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.12	0.72	-4.21	18	267	2011-05-13 15:01:36	2011-05-13 16:01:36	1	2	239	0	12	86	7	48.60	53	41.50	CHANGED	K....YcVcIsETLp+hVpVcAcoc--AhphspchYpsp-..IVLss-DFps.s-	.....KKYsVEIsETLSRlVSlEAE.s.D.EAccLVc-pYpspE..IVLDADDFpsh-................	0	7	10	11
+14050	PF14208	DUF4320		Domain of unknown function (DUF4320)	Eberhardt R	re3	Jackhmmer:B0PFN6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 120 and 131 amino acids in length. There are two completely conserved residues (G and Y) that may be functionally important.	25.00	25.00	25.10	25.20	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.45	0.71	-10.13	0.71	-4.14	20	145	2011-05-16 07:46:53	2011-05-16 08:46:53	1	1	99	0	15	97	0	116.10	30	89.67	CHANGED	llLsshllIALuVclhPlalsKppLDsFAsELVRpAEluGplu.......sETsp+ttsLcE+TGlsPp..lpWS............psG+IQLNp-lsVTlThchclGlFu....sFu...SFPlTlpApAoG+SEVYaK	...hlhhulllIsLhspsshhhhph.chcsaAsphlc.AEpsGGhs.......scssshltslp.c+.httpsh....hsWc.-..........ppG+lpaNpslshplpuchc.hhlFt....shs...shclslpAptsGhuplYa+................	0	11	15	15
+14051	PF14209	DUF4321		Domain of unknown function (DUF4321)	Eberhardt R	re3	Jackhmmer:B0PGC7	Family	This family of proteins is functionally uncharacterised.  It is found in bacteria, and is approximately 50 amino acids in length.	27.00	27.00	27.50	27.50	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.15	0.72	-4.27	43	156	2011-05-16 08:00:46	2011-05-16 09:00:46	1	1	155	0	48	130	27	48.70	31	56.63	CHANGED	hlsaLshshs..lGhsss......slDLtllplohG.lslclNlhoIlGlllAlhlY	............lsaLshshs..lGhsssh.....sLDLtllploFG.lslclslhoIlGlllAlhlY.....	0	29	43	46
+14052	PF14210	DUF4322		Domain of unknown function (DUF4322)	Eberhardt R	re3	Jackhmmer:D2PCT9	Family	This presumed domain is functionally uncharacterised. This domain family is found in archaea, and is approximately 60 amino acids in length. There is a conserved QTV sequence motif.	27.00	27.00	28.20	33.90	20.30	22.60	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-9.13	0.72	-4.50	7	162	2011-05-16 09:56:38	2011-05-16 10:56:38	1	1	13	0	20	159	0	58.40	72	22.23	CHANGED	hTPsh.pp.shpQIsaKLLShlsFpGRKuEEVpKsLVSAuLhpDSVENKuptaslSPQTVRNYsEE	...lh..LPHQNNlQQIGYKLLSMLNFpG+KuEEVA+TLISACLWNDSVEsKSRAYsVSPQTVRNYVEc............	0	18	18	20
+14055	PF14213	DUF4325		Domain of unknown function (DUF4325)	Eberhardt R	re3	Jackhmmer:C4FKE5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 99 and 341 amino acids in length.	27.00	27.00	27.10	27.40	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.24	0.72	-4.33	60	205	2011-05-17 10:57:51	2011-05-17 11:57:51	1	5	197	0	61	187	21	71.20	22	43.03	CHANGED	ppupclhpp.lpphlptst...VhlDFpul.phhspuFhsphhuplhtphs......tthcpplphhshscsspthlp+.lhsp	................pupplhpp..l.....t....phhpttp....lh.lDFcGl.stlusuFhcEsFushhp.c..hs.........t.hcpplphh..shspphpthlth.h................................	0	19	43	52
+14056	PF14214	Helitron_like_N		Helitron helicase-like domain at N-terminus	Coggill P	pcc	Jackhmmer:Q9S9S3	Family	This family is found in Helitrons, recently recognised eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.	28.70	28.70	28.80	28.80	28.40	28.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-11.11	0.71	-4.56	42	666	2011-05-17 12:28:46	2011-05-17 13:28:46	1	43	74	0	525	652	26	155.40	26	14.84	CHANGED	Ya..sa+l..phRpsphshhhp...st+LhpQa..hVDtaspl-ps..RLpalp..p..pQpplRschhpulpDA............hppups.cs...sphGc+ll.LPuSasG.u.RahhppYpDuh.....Als+taGhPclFlTFTs.Ns+WsEItct...............lt........sppspD.....................RPDllsRVF+hKlcpLhc-lhpp...phFGp.shs.hhaslEFQKRG.LPHsHlLla	...........................................................................................................h...h.....hp.....h.pt....phthht..........pp.tph.....pt.................h.tt..l.pt...................................ht.tttt..ph......p.t...h...pphh..hstshhG.....s...........phhhpph..-sh.....Ahspp....hGt..P.slFl.Thos.s....s....p.Wt-.l...hph...................lt...........tp.psp..D...................................cPshssRh..Fph+......hpthhp.lhtt...................thh.Gp...l.t.hhhhhEaQtRG.sHhHhll..........................................	0	194	351	473
+14057	PF14215	bHLH-MYC_N		bHLH-MYC and R2R3-MYB transcription factors N-terminal	Coggill P	pcc	Jackhmmer:A8MSG2	Family	This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, Pfam:PF00010. Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species (DOI:10.1007/s11295-009-0232-y).	22.20	22.20	22.20	23.20	21.70	22.00	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.04	0.71	-4.04	95	661	2011-05-17 12:29:08	2011-05-17 13:29:08	1	12	127	0	262	681	0	164.70	31	30.79	CHANGED	Lp....ppLpsllp.......stpWsYAlFWp.s..........................................lLsWuDGaap.us.p.t.t......................t.t.t+pp.hpch.p.hs.........................................hth...-lsssEhaahssh.asa.....GpG...........lsG+shssupphWlssspp........h..ssphhs.........R.uh.Ap.tuh...p..............Tllsl..Ps..s.GVlELGSochlhEshshlppl+shF	.....................................................................................pptLthhsp.......s.p...WoYulFWphsspp...........................................................hLh.WsDGaas.Gshcscpt...........t...................ththpRsctLc-Lht.h..s...............................t.sssshss--ls-sEha..alhshsasF.........GpG.....................LPG+shusspplWlssspp................................s....ssphht...........R.uhhAp..tuh......................TlVslPh..hsG..VlELGoTchl.E-.shlppl+shF.................................	0	48	172	220
+14058	PF14216	DUF4326		Domain of unknown function (DUF4326)	Eberhardt R	re3	Jackhmmer:A8ZQW0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 100 and 162 amino acids in length. There are two completely conserved residues (P and C) that may be functionally important.	25.00	25.00	27.30	25.30	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.28	0.72	-3.41	43	174	2011-05-17 12:59:55	2011-05-17 13:59:55	1	3	156	0	61	180	43	92.70	29	68.43	CHANGED	splspp.+ttphss...........t.h.YlGR..........sop.....W.GNPFshsp.................sssR........ppslcca+pal.................tppshhhptlt.cL.......+G.+.sLuCaCs......P.........CHuDVLt-l	.......................................p..ht.ths...........h..al.GR..............soh.....a.GNPFthtt..............................................ttsR.........ppslcta+palh..................................tssphhhptlt..pL.......c.G...+..pLuCa.Ct..................P.ts.............CHuDVlhc................	0	19	47	56
+14059	PF14217	DUF4327		Domain of unknown function (DUF4327)	Eberhardt R	re3	Jackhmmer:B0BYV4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length.	27.00	27.00	75.80	75.60	21.30	18.80	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.14	0.72	-4.16	39	113	2011-05-17 13:09:37	2011-05-17 14:09:37	1	1	41	0	44	101	0	67.60	45	88.51	CHANGED	paol-hIp-EARpLVcpGllpRpQPIasLspalPuREWshlEpELEcp-FLLRDpIsDLlu.sEsWc..-D	...YolchIp-Es+pLVcpGllsRpQPIYsLCpaIPuREWstlEpELEcp-FLLRDpIuDLlu.sEsW-pD...	0	5	32	44
+14060	PF14218	COP23		Circadian oscillating protein COP23	Eberhardt R	re3	Jackhmmer:B0C7I3	Family	This family includes the circadian oscillating protein COP23 from Cyanothece sp. (strain PCC 8801), Swiss:Q54702. The levels of this peripheral membrane protein display a circadian oscillation [1].	27.00	27.00	30.90	30.40	17.60	16.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-11.05	0.71	-4.60	63	131	2011-05-17 13:43:54	2011-05-17 14:43:54	1	6	38	0	42	156	4	146.20	22	65.35	CHANGED	pFhCt.........................................hssp............sTlstpsp..uph...slltWs....s.h.suuaoPppRCppVosRhpphtss....h.................th.hlps..Ghh.NspsVlCsssptss.sC.....pslLhTL..pssss.....sppsLpplhs.......t..p.................................ttstp......hlshsshLsss	.................................................pFhCt........................................tsp.......sTlshpsp....uph...PllhWs....sth.susaoPppRCppVSsRhpphhps....h...............................thphlps..Gph.Nsp.sVICsssptss...sC...pslLhTL..pssss.....Pppslpplhshht....t....s....................................psstt.......lphp.hlt..t.....................................	0	1	33	42
+14061	PF14219	DUF4328		Domain of unknown function (DUF4328)	Eberhardt R	re3	Jackhmmer:B0C5R9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 218 and 342 amino acids in length.	24.80	24.80	25.30	25.00	23.40	24.10	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.49	0.71	-4.96	51	224	2011-05-17 14:05:06	2011-05-17 15:05:06	1	7	194	0	73	216	1	164.40	23	55.87	CHANGED	lltphpssh.............ht.sthstu-thssh.....suhsthlhhlsssllhlhWlhRs+tsApsht............ts.chsssh....slsuahlPlsNLhhPhphhtElapuotths.............................t.sthlhlW...W.....hhWl.................lutslshhshshs.....htsssptls..............tsshhslhsslhsls..sulhslhllcplsp..hp	..............................h..............h...hhttushhssh.....su.lsshhshlsshllhlhWLhttRssAhhhts...........hs.Rhust..hhuGhhlPhlNLhhshhhlhElhtspsphs.............................phpthlssW....W.....hsWl.................lussl.s.h..hs.hshp......hss..sspshs...................ssshh...hlluhlhuss..usshshhlhcthpp.....................................	0	29	57	68
+14062	PF14220	DUF4329		Domain of unknown function (DUF4329)	Eberhardt R	re3	Jackhmmer:B0C699	Family	This domain is functionally uncharacterised.  It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with Pfam:PF05593 and Pfam:PF03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.	27.00	27.00	30.70	30.30	26.70	25.90	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.62	0.71	-4.17	20	415	2011-05-17 14:18:05	2011-05-17 15:18:05	1	16	244	0	18	432	7	126.10	48	15.32	CHANGED	tpshApshLpplpscSIspspEYsGhIsp..sssGchhuo..psppG..........ppsushsths.s..shphVAuYHTHGuasps...........YssEl.SstDlpus........tpptlsGYluTPuGRlahlc.psppsp.phsshusl	.........................I.DDhuh.ALshhNucSIsEsKEYuGLICK......ppG.cYF.so...sP.su.........s-pcus..hNhtCPpGoE+VusYHTHGh.Scs.............sYss..FSuKDhp.sh............uhspp.hu.Y...LGTPsssahthss+u+t.s.........sp............	0	8	12	15
+14063	PF14221	DUF4330		Domain of unknown function (DUF4330)	Eberhardt R	re3	Jackhmmer:B0C6A2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 165 and 177 amino acids in length. There is a single completely conserved residue G that may be functionally important.	27.00	27.00	30.40	28.90	23.30	21.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-10.97	0.71	-4.40	43	119	2011-05-17 14:26:20	2011-05-17 15:26:20	1	2	109	0	50	119	32	159.90	25	88.80	CHANGED	M..t...llDspG+LFG+lSllDlsAslllLhslsGlhhhPtt..osss...Aph...ssspslpV..sl.lhsltsssPpshhtp.hpt.......spcssllIRNQPh......GplpltsVp.ls+plssspPDGsVhshsD...Pp.t..hphDhhhTLcGpupho.ssGs...VlGspclKIGsslELEGpsYphsGoVh...slcl	..................................M.llDpcG+LFGplsllDlhshllllhs.lsGlhhhstp.ssss.....Ap....ssspslcl..shhlhslpstsspthhtp.hpt.......sspsshhh+spshG....plpslp.h..spsh.hsspsDGp.Vh.thsc...P.....hthDhhlTlcupupho..ssGs.....llG.spcl+lGps.lpl-stsaphsusVhslp........................	0	17	36	47
+14064	PF14222	MOR2-PAG1_N		Cell morphogenesis N-terminal	Coggill P	pcc	Jackhmmer:Q9LFV8	Family	This family is the conserved N-terminal region of proteins that are involved in cell morphogenesis.	20.30	20.30	20.50	21.50	19.30	20.00	hmmbuild  -o /dev/null HMM SEED	552	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.96	0.70	-5.83	35	407	2011-05-17 14:28:14	2011-05-17 15:28:14	1	28	236	0	259	372	3	456.00	35	21.39	CHANGED	u-..R+uhlSl...YllCRVLIEIhpQss.hp.slsp-htc+LEsllFsQL..KssD.s.....p.ls.sSsl+huNWslaApLLGhh..SchpF..sSVocRFls-Lcc........hp.p......pps......cs-sphthLIhGMRaL+l+saP.Esa-cSs-Fhpulu+hFspup.pc..lKpAaspllpplLLPlAussss-....lspP...pWs-slstlhschsphhs..K.s+HWss..u.FPLtssLLClSsp-hFhspWh....thlpsL.s+lKD+..spR..sluLpulsRLlWsYL..apss-ossssh++L-plhchhl..Psu+.........+..shlssD..shh-PLlpllphIuac+.Dash+pIIaPLlssshhtss.....lcplpPE+hllGIRuaLsIhsshppspt......................................t.h.tsppc......hls......s...ssth.spslppaa.chschlsc.IhllhDsshGupshh....s.....cphst.p..ssht...................h.hthpsD.ph...o..sp....+pth...-L.h+sslpAlPRCL..us..pIPa..ssLIslLspsssHlpssIupouupuL+uluppp..tsppVhhGFA+FlFs.FD-+asoh.s.th.Ls..cl-ssL+L.YlELLplWl	......................................-R+shs..aIhshVLlEllpQhs..hp.sh.c.....th......hpcl.slsFpph..Kht-..s.........s.sush+.h.hslaApllGhhup.t+.......F.uVpc+Fhs-Lcchp.p...........p.s......s.tphh.LlhGM+ah+l+hhP..EtaEtShpFhp.phuphFhcs...pc.tlKpAhstlhsplLlPlAuss.psE.............lshP......phtphlp.lh.pshph.s..+...p................+H.....................hs.........h..aP.LhssL.....LClSppphF..hs.pWh...................thlppLh.........K.................D......ph..p..tluLpulhRLlWsYh..hhps-o.s.....sT..p..+L.plhphlh.....Ppsp...................+..shlspD...h.ls.hlpllphIu.c+.D..ash+pllhsLlsssh.hp....................................h.plpPE+hsIGlRuaLsIhsslppt-t.ss...p...............................................................sssshpspph..pphls...........p.ptsps.uhp.Yasphpchlsp.IhhhhDpphGp.hhh.....s............ph..h..s..p...............................................c.cD..hh...o.....sp.....Ksph..-L.F+osltAlPRhl.........sc.........shsh.................ppLl-lLs+..h.olHh-pplpt.u.poLpslhhph..atpsVhhGFspFlhc.hsDha..sh.....................l-ssl+hhlpLlp.Wh....................................................	1	76	133	204
+14065	PF14223	UBN2		gag-polypeptide of LTR copia-type	Coggill P	pcc	Jackhmmer:A5B9L3	Family	This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.43	0.71	-10.24	0.71	-4.31	123	1538	2012-10-02 13:37:57	2011-05-17 15:37:42	1	195	75	0	589	2426	5	103.70	21	14.09	CHANGED	coAKchW-sLcpha.Gss..+s+tuclppLcpca-plcM+-sEolc-ahs+lpslssclpslGp.phs-pclVcKlLpoLP.p+appllsul-pt..hDhpp.hol--lhupLpstEp+h.ppppsp	...................................................................stthWphlpt.atss..p..p......s...ph..lppph..t.thp........h.p.ss....c.s.l...p...-aht..+hp...sl.ss...p.l.....p.............s.l.....G.............p....s....h......s.........-p.........cl.lp..+..........lLp.....u.....L....s..pc..ap..hhss...lppp...sht.....ohp-lhspLh.shE.ph......t...................................................	0	132	305	345
+14066	PF14224	DUF4331		Domain of unknown function (DUF4331)	Eberhardt R	re3	Jackhmmer:B0C6N1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 223 and 526 amino acids in length. There is a conserved FPY sequence motif.	27.00	27.00	32.60	32.40	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	359	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.61	0.70	-5.29	47	155	2011-05-17 14:40:04	2011-05-17 15:40:04	1	2	121	0	70	177	49	349.20	25	90.04	CHANGED	SoHc-uP....htttsphDhTDhYhFpS.............tcsstlsllhNh.Php.......sssshhthsssuhYcl+l...........DscG......-..uht......D.lsapFpFss...............................................................................h..sshGptsh.........shtthtst.l.t...h...s......shpsFsGpRpDsFhhs....l.thapl.........................th...t.s.sshtsh.NVpolulclPtstls.t..........t.slGsWsossh.........................h.sGsasQlsRlGpPhlNcl..h...hsh...t.-.KDpaNsspPspD...upahshhtsshhstlhth...h..........................hsRsDllsshlsshst..........................h..s-hLclssuhPss........................................uuaPNGRphs.......DDVlDlsLphlhG.h.....................................t.hshs..cssshsss..shhssFPYLusP	...................................................SsHh-uP........hst...tsphD.oDhYsFpu.............tpsstsshlhNh..Pht.......sss.sh...hshs.sshYcl+I............DssG...D.uht.................D.lsapapFps...s...............................................h.p.ht...........................h.hs.sthGttshs..............shtth.tst.lht....hss..........shpsFsG.tpDsFhhs...htthhclht..............................h..sh...t.s.sshtsh.NVtolslclPpshlstt.................tsslusWsosph........................................sGsahQlsRlGtPhlNpl..h.hs.........t.s.KDtaNsstPtpD...spahphhhps...hshhht...hh...........................................................scschlshhhtsh.t..............................s-hLplssuhsss............................................suaP.NGRp.s.......DDVlDltLphlhG...................................s.....t.shh..sssshsst...h....ssFPYLs.P............................	0	19	44	65
+14067	PF14225	MOR2-PAG1_C		Cell morphogenesis C-terminal	Coggill P	pcc	Jackhmmer:Q9LFV8	Family	This family is the conserved C-terminal region of proteins that are involved in cell morphogenesis.	25.00	25.00	25.50	25.50	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.63	0.70	-4.64	38	388	2011-05-17 14:50:41	2011-05-17 15:50:41	1	28	236	0	230	364	0	247.40	32	10.74	CHANGED	cLltaPQLFWsssACLsolaEpEFlEuLphLs+hLsKlDLcsssshphLhsshPsp...........................Wp...GsF-GLQsLlhKGL+SSsoh-hTLclLs+Lshlsssplluss.po.RLlh.sllAsLPphLpph-pss..............pphhpsAptLuplA...cspshssLucllsuaucs+a.+opcDFlsphlshlpstaFPchpspslsaLlGLLpNshsWh+lpohplLpsllstlDhc....ps....hGs....D....LIuPLLRLLpT-hs.pALcVL.-plhshSGu.hhsc	...................t...hhsplFWsssuhLcSs...a...EhEal.uLcLLs+lLs+.....ls.Lcc....s....pspppLtphpsph.......................................................h....ssFsG.LQpLllKGh.....pSss..oh-hTlplLspLssl..spp.sll......ssu.......p.......s..t.....h.h.sllshLPphlpph-sss...................................................phsp..psA.pplAp.ls.............cstphs...sLAchhshYupppa.+sspsalshlsphL+.-sahschshphlsa.LhpLL.pp..uhs...hp.plLpllhslLsh....hDhp.............ps.............hss-.......l.lpsl.h+hl.posahtcALplL.chllohSuo.h..h.................................................................................	0	68	115	177
+14068	PF14226	DIOX_N		non-haem dioxygenase in morphine synthesis N-terminal	Coggill P	pcc	Jackhmmer:Q94JV6	Family	This is the highly conserved N-terminal region of proteins with 2-oxoglutarate/Fe(II)-dependent dioxygenase activity.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.52	0.71	-3.55	783	5634	2011-05-17 14:57:58	2011-05-17 15:57:58	1	32	1392	66	2627	5670	1247	113.90	22	34.09	CHANGED	lPlIDlu.............s.....ss......c......p...ph.....h.p.p...ltpAspchGF.F....l...sNH...G...ls..p.......p.llpchhp.huccF.F.s.LPh-...c.Ktc.h.....tp.....s....s......th...pG...Ys.sh...htpph..ps.................phDa.cEt.h.phtt.p..........s.........p............................h.sh...WPsp	....................................lPllDls........................ts...tp.......p..tph....hpp...ltcAsp..p..hG..F.F.............l..............s..N..H......G...l....s..t........................p...l...l...c.ch.hp.......hs..ccF.F...s.L...P...h-...p..Ktch.........tp.....s.....s.................th..pG...Ys..s..h...h.t.p.p.h.ps................................th-a.c-h.h..t.h.th................................................................................................................................................	0	523	1614	2211
+14069	PF14227	UBN2_2		gag-polypeptide of LTR copia-type	Coggill P	pcc	Jackhmmer:Q1PE19	Family	This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.64	0.71	-10.25	0.71	-4.55	97	1112	2012-10-02 13:37:57	2011-05-17 16:31:27	1	127	81	0	605	2057	3	105.80	19	15.57	CHANGED	ppoutplWppLcphahspshss+lhl...hp+lhsh...+Mp-sps.lp...palscFppllscLpsl.slpls-E...spshhlLsSLP.ss..acphhss...lh.st..splohcpltstlhs...c-hphppppppsps	.........................................................pstphWptLpt.h...att....p.s.....h...s...s...c...hhl.....hcphhsh........+ht.-.......s.......ps..lh.......palpch.p.ph...sp.cL....p....s....h....p........h....t....l...s.-c...........h.s.hhlls...sLP..ss........ac.shhts....l..hp...t......p.p.h...shpt.lhstl..........c-.thttt.....st.............................................	0	306	380	445
+14070	PF14228	MOR2-PAG1_mid		Cell morphogenesis central region	Coggill P	pcc	Jackhmmer:Q9LFV8	Family	This family is the conserved central region of proteins that are involved in cell morphogenesis.	27.00	10.00	27.10	10.00	26.60	9.90	hmmbuild  -o /dev/null HMM SEED	1120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.43	0.70	-14.01	0.70	-6.99	3	1087	2011-05-17 15:34:39	2011-05-17 16:34:39	1	28	226	0	651	1024	4	217.20	9	27.26	CHANGED	tEuSEFRASEMDAVGLIFLSSlDVQIR+TALELLRCVRAL+NDIRDYStpEphDspLKs-sEPIFIIDVlEENGEDIVQSCYWDoGRPYDLRREhDslPlDlTLQSIL.ESuDKuRWARCLSELV+YAAELCPSSVQ-AR.....LEVIpRLApITPsELGGKApQSQDTDoKLDQWLlYAMFACSCPPDSRE-uuLRAARDLaHLVFPSLKSGSEuatLAAThALGHSHLEVCEIMFGELTSFlEEVSSETEuKPKWK......SQK..t.RREDLRVHVANIYRhVAENIWPGMLoRKPlLRLHFLKFIEETsRQILsuPSENFQEIQPLRYALASVLRSLAPEFVDAKSERFDLRsRKRLFDLLLSWCDDoGSTWGQDGsSDYRREVERYKASQHsRSKDSlDKLoFDKEluEQVEAIQWASMNAMASLLYGPCFDDNARKMSGRVISWINSLFhEPAPRAPFGYSPADPRTPS.YSKa..TG..EGsRGuuGRDKQRGSHLRVLLAKoALKNLLQTNLDLFPACIDQCYSSDuuIADGYFSVLAEVYMRQEIPKCEIQRLLSLILYKVVDQoRQIRDDALQMLETLSlREWAEDGuEGuG+YRAAVVGNLPDSYQQFQYKLSuKLAKDHPELSEtLCEEIMQRQLDAVDIIAQHQVLTCMAPWIENLNFV+LKESGWSERLLKSLYYVTWRHGDQFPDEIEKLWSTVASKsRNIlPVLNFLITKGIEDCDSNASAEISGAFATYFSVAKRVSLYLARICPQQTIDHLVCELAQRMLEDssEPVR.ussKsDTSuNsVLEFSQGPssS.QlAolVDSQPHMSPLLVRGSLDGsIRNVSGNLSWRTAAVTGRSVSGPLSPMPPElsIlNVTTGRSGQLlPA...LMNMSGPLMGVRSSTGSLRSRHVSRDSGDYaLDTPNSuDDILHuG.sGsHGlNApELQSALQGHpQHhLSRADIALILLAEIAYENDEDFREHLPLLFHVTFVSMDSSEDIVLEHCQcLLVNLLYSLAGRHLELYEV.EsSDuENKQQVVSLIKYVQSKRGSMMWENEDPTLVRTELPSAALLSALVQSMVDAIFFQGDLRETWGuEALKWAMECTSRHLACRSHQIYRALRPSVTSDTCVSLLRCLHRCLGNPVPAVLG	........................................................................................................................................................s.tts...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tttt......................................................................................................................................................................................................................................................................................	0	151	278	466
+14071	PF14229	DUF4332		Domain of unknown function (DUF4332)	Eberhardt R, Bateman A	re3	Jackhmmer:B0C7H1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 134 and 356 amino acids in length. This domain contains helix-hairpin-helix motifs.	22.30	22.30	22.30	22.30	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.12	0.71	-4.15	49	244	2012-10-03 02:11:09	2011-05-18 08:15:57	1	15	232	0	88	272	276	105.00	25	30.05	CHANGED	.GlsptptppL.ppsGIpospsLLptucs.tuRhtLApphtlstpplh+htshADLs.Rl.uluhpausLL.pAGlsoVspLApps.sppLpppltclptppphs+ph.....Psls.VppWIppA+pl	..........................................................h..t.sl.p..th.t.t....tp..h...tt..ht.t.l.th..t.s.phh.ph.GluppastlLpcAGlsolp-L.sp.ps.sppLpppltclNcph.clttph.....PolpplppWIppAp..........................	0	31	58	79
+14072	PF14230	DUF4333		Domain of unknown function (DUF4333)	Eberhardt R	re3	Jackhmmer:B0C9G5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 140 and 255 amino acids in length. There are two completely conserved C residues that may be functionally important.	27.00	27.00	27.80	27.30	24.10	25.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.65	0.72	-4.02	37	334	2011-05-18 08:13:58	2011-05-18 09:13:58	1	5	143	0	89	229	0	79.00	32	49.87	CHANGED	sssssusuhhhss........slDtsplppslpphLs....sshGhpsss.VsCP..ss.cscsGsohpCs.hs..lsGpshpVsVTlpss.DG	.......................h..h.hhhuh.hss....hs.p......slDpspltstlpphLs....sshGs...+sss.VsCP...ss.pscpGAshpCp.ls..ls.Gp.shpVsVTlsss.-G........	0	18	65	80
+14073	PF14231	GXWXG		GXWXG protein	Eberhardt R	re3	Jackhmmer:B0CA20	Family	This domain is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. There is a conserved GXWXG motif. This domain is frequently found at the N-terminus of Pfam:PF14232.	25.00	25.00	26.60	25.10	23.00	21.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.91	0.72	-4.32	50	169	2011-05-18 13:18:05	2011-05-18 14:18:05	1	2	133	0	86	180	1	58.80	39	34.55	CHANGED	hslFDpLssVss-.hl.GpW+Gutl.TGHPh-GhLpshsWaGKpFhss-sVcPLlhhss...cG	.......phassLssVps-thl.GpW+GsthsTGHshsGhLpthsWaGKpFpsspcVcPLlhhsssG.......................	0	9	53	72
+14074	PF14232	DUF4334		Domain of unknown function (DUF4334)	Eberhardt R	re3	Jackhmmer:B0CA20	Family	This domain family is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. This domain is frequently found at the C-terminus of Pfam:PF14231.	25.00	25.00	26.80	25.50	21.10	17.60	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-8.87	0.72	-4.33	50	165	2011-05-18 13:43:53	2011-05-18 14:43:53	1	2	132	0	85	176	1	60.60	45	35.32	CHANGED	sppupApLRhhpaRGtsoAoMlYDphPIhDhFR+VD-....sslhGlM-hKs.........tspsaFFhLcR	...h.ttupApLphhcFRG.....ploAoMlYDtpPlhDaF++lD-....solhGlMshKs.........psp.a.aFhLcR.............	0	9	52	70
+14075	PF14233	DUF4335		Domain of unknown function (DUF4335)	Eberhardt R	re3	Jackhmmer:B0CBF9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 204 and 480 amino acids in length. There are two completely conserved residues (G and D) that may be functionally important.	27.00	27.00	52.70	52.60	20.50	20.00	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.20	0.71	-4.83	55	113	2011-05-18 14:47:08	2011-05-18 15:47:08	1	1	70	0	44	125	119	193.20	27	57.39	CHANGED	+pYs.PsCoLplpGhss.h....stspscshlslLsts-sp.h....sp...lcGs+-aLcsLhpsVssYspphLS...........................uhs.p.......phst-ssh.............................................lplps........psh.tH...cLhLpu........ttsssss.................hplpLsssQLaDLlpALDphtsDspsLsshshshp.......h++ht...h..sstshhpphsssslG............................ssulslsuhhh...hhlPhPp	........hpYs.PsCoL.l.uhss.h....st..sthpshhthLp.s-sp.h....st...lpGs+phLEsLhpsVssYspphLo...................................uh.........tptph...........................................................................lplps.........sh.tH......cLhlts.................tspsss.....................htlpLsssQLFDLlpAlDpahsDspsLsshshphp........++ht....tsstshhpphsssslG.........................shulshsuhhh...hhhs.P...................................................	0	7	31	42
+14076	PF14234	DUF4336		Domain of unknown function (DUF4336)	Coggill P	pcc	Jackhmmer:Q8RWI4	Family	\N	27.00	27.00	27.20	27.10	26.10	26.80	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.86	0.70	-5.23	47	413	2011-05-18 16:09:10	2011-05-18 17:09:10	1	4	339	0	204	422	226	203.30	28	65.88	CHANGED	ssplWoFEQlQGlhY...VsVPIRMTVlKLps.GGLhVauPlAPTtEhlphlcc..L..t.cG....sVcaIlLPTsSG........lEHKlalGPhARtFPpApVWVsPsQWSFPlsLPLs..WLGhP....ps........+s..L.s........h....sss..........ssPas.DEh-athLsPlsLGlG..s.....FtEluhaH+tSpTLLVTDullulstpPPt.lhshDP............hPLLF.........HAR-p..us...csltDosps..R++GWpRhsLFuhYhpPs..sL.................pss....................ph.phh..t................h.a..tWp.sh..sFptlps.....+...LhVAPlLpsLlasRs.ptlhsWl-cl............up.W..s.....hc.........pllPuHasAPlts.sspchppAFsa	...........................................lshssRMTVl+Lss......G.......u.....LhlaSPls.TpclhptlppL.........G.sVcallsPsh..h..........H+lalssapctaPpApla....ss...P.......s...................t......ph.....h....p........hhsh..........t..t....h................t....t.pt............ss...as.s-h.-..hhhp......t..t.........hpElsFaH+sSpTLllTDhl..sh....p...........................................................................................................................................................................................................................................................................................................................................................................................................	0	66	121	171
+14077	PF14235	DUF4337		Domain of unknown function (DUF4337)	Eberhardt R	re3	Jackhmmer:B3DVT1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 201 amino acids in length. There is a single completely conserved residue Q that may be functionally important.	27.00	27.00	30.20	28.80	24.00	26.20	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-10.82	0.71	-4.39	47	143	2011-05-19 08:31:57	2011-05-19 09:31:57	1	1	133	0	74	139	31	162.60	30	84.08	CHANGED	hspplAlhsulLAsluAlsshtuss.......hpscuhhppscAuspWuaYQAKohKpslhEhssphhthph............psthppclpcYppcppchcpc......ucpLppcAcph-ppp-pthcpacpashAsshlQIuIsLAulslLT+.+phLhhhuhuhussGlshhshuh	......................spplAlhsAlLAshuA.lsshtGss.......hps-A.slppscAuspWuaYQAKohKpsls-husphsthph................psthppclpcYppptpch+pc......................ucplppp..Acct-cpp-tthcpaHcashAsshlQIuIsLAulolLTc.....pphLhhh....uhslussGlshsshuh.......................	0	19	47	62
+14078	PF14236	DUF4338		Domain of unknown function (DUF4338)	Eberhardt R	re3	Jackhmmer:B3E1A9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 206 and 475 amino acids in length.	27.00	27.00	27.30	28.60	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.73	0.70	-5.75	26	167	2011-05-19 08:39:33	2011-05-19 09:39:33	1	8	64	0	33	167	423	198.60	25	54.41	CHANGED	php+cslhpLstsppp..phttpptthst.........hssspsshschhs.pLphVcstsp...pLFphhhtp.a.LsaspshGc+LRYLVhsptp....t...llGhLuhuussapltsRD.caIGWsppsR+ppLhplshsu+hL..I.Pasplhsht.hlLuhsspclpsDapcpYstpshllEs........hVsssphhG..osYptss..................Wh.lGtTpGpG+hcht..................................................hhh+ts.h+-lalhPLscshcchLps	............................................................t..................................................thht..lp.Vpp.pt........p......thap..hhtp...H.Lshp.hhGppl+Ylshsttp...............hluhl..uauusshphtsRD.paIGWs.pt+pppLhhls.ssRhL..IhPh.hpl.shtShhLuhshccl.pDatphYshp.hllEo............................alsspp..hh.G....osYptsp.......................Wh.lG...TpGhuc.t...................................................................................................................t...................................................	0	15	25	29
+14079	PF14237	DUF4339		Domain of unknown function (DUF4339)	Eberhardt R	re3	Jackhmmer:B3DVT0	Family	This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.	26.00	26.00	26.00	26.00	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.95	0.72	-8.06	0.72	-4.38	59	701	2011-05-19 10:27:33	2011-05-19 11:27:33	1	48	515	0	277	694	67	44.80	29	6.35	CHANGED	paahsp.NupptGPashppLpphltsGplss-oLVW+pGMss.Wpsh	...............Wah.sp....s..s......p...p......tGPhshpplpphhtpGplst.sThlWppGhss.Wpsh......	0	109	177	238
+14080	PF14238	DUF4340		Domain of unknown function (DUF4340)	Eberhardt R	re3	Jackhmmer:B3DYU8	Family	This domain is found in bacteria, and is typically between 183 and 196 amino acids in length.	25.00	25.00	25.00	25.00	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.31	0.71	-4.60	71	627	2011-05-19 11:01:47	2011-05-19 12:01:47	1	8	364	0	213	647	246	159.80	14	62.45	CHANGED	sWp.ls.s...s.hs.......hssDpsplsshlssLpplphpchls.....ssss.h.scaGLsss........thplsltsss.......s.p..tplh.lGs..sss.s.....sp.....hYs+h..stpsplah...lss...shhshh..s.tshss....a.hspp.lh...s.h....ptsp...lpplplpt.....tspt.........hph.........spps...s.....tWph.ss....s....tt......pss.ssps..sphls.slspLpsps..hhstps......sphtthsh.ss....Pth	.........................................W..h..t......t.......h.hs.t.t.t.lp.phhptltthph.p.hp.........s.spp.htpa..GLsps............................thplplp.tts.......................t.p....hplh..lGp..s.ss.s......................sp...........h.Ys......ph......t...s...........p..s.....p....lah.....lst......shhp.h...s..ts.t..p....h.hppp.lh......p..h......t.tp....l.pplplp............tt.................hph.........................tttt..t.......th.h.tt..............................ht....h..tthht...h..h.h.t....h........................t.......................................................................................	0	128	169	184
+14081	PF14239	RRXRR		RRXRR protein	Eberhardt R	re3	Jackhmmer:A8ZLD7	Family	This domain is found in bacteria, eukaryotes and viruses, and is approximately 180 amino acids in length. It contains a conserved RRXRR motif. It is often found in association with Pfam:PF01844.	25.00	25.00	25.50	25.60	24.60	24.50	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.09	0.71	-4.86	49	361	2011-05-19 12:12:55	2011-05-19 13:12:55	1	6	102	0	87	389	36	159.60	40	43.18	CHANGED	VaVLspst+PLMPs+s.u+ARcLL+pGKAtVh+..hhPFTIpLptp..tss.tsQP.lpltlDPGu+hoGlul....hssp..cslhsuclplhhtpl+ctl..................tspRphRRuRR.sR+h.....RYRpsRFsN..R....c+..s...tW..Ls........PSlpp+VcsplphVpcLp+lhPlosIshElV+FDhQthps..P-IsGhpYQpG	...................VhVlspptpPLhPsps.u+ARhLL+pG+AtVh+....thPFTIhLpp......p....sss.........sQP.lpltlDPGu+hoGlAl..............hppp..............ps..............latuElphRtp.pl+ctL.................ppRRthRRsRR.pR+h..............................RYRpsRF.NR................p..+...p...GWLs...............PSlpp+lpshhshVp+LpchhP..lss....ls.....ElV+FDhQthpN....P-l..sGhpYQpG..............................	0	33	62	83
+14082	PF14240	YHYH		YHYH protein	Eberhardt R	re3	Jackhmmer:A8ZMB4	Family	This domain family is found in bacteria, eukaryotes and viruses, and is typically between 141 and 198 amino acids in length. There is a conserved YHYH sequence motif.	25.00	25.00	26.00	25.40	23.00	24.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.42	0.71	-4.58	57	242	2011-05-19 12:29:31	2011-05-19 13:29:31	1	18	133	0	117	242	1052	161.80	25	17.45	CHANGED	shsaplPhs..P.thu...........sps..sshsh....sshGlAlNGVsh.ssss...................t.t..s...s...hhs........................slDpssuHspssG.sYHYHuh.Ps...shhp.t...tt...ssc.............usllGaAhDGFPIY..u...hs.sss..p............................................suDLDcCNG+hsss.......GtY+YalTssa...Pal..pCa+Gs	.................................................................................p...h.lshp..P...t.............tps..pths...........sslGlslNGlsh.sshs.............................t...s.....t......................................shD.ts..sGHs....p..s.u....sYHY..H.........t......ss...shhp....tt......ssp.................................usllGaAhDGFPIY..Gs.hs.sss.p..........................................................................................t..s...s.......D..LDpCsG+hsss........................utY+....Y....asT....tsh....shh.tshhG............................................................	0	65	96	111
+14083	PF14241	DUF4341		Domain of unknown function (DUF4341)	Eberhardt R	re3	Jackhmmer:A8ZP08	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 60 amino acids in length. The family is found in association with Pfam:PF04143. There are a number of conserved glycine residues that may be functionally important.	25.00	25.00	25.30	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.99	0.72	-4.27	233	845	2011-05-19 13:03:03	2011-05-19 14:03:03	1	3	766	0	330	765	339	64.00	36	39.15	CHANGED	sPhhuLhGGhLIGluAslLllhsGRIAGIS.......GIluu.....l........lss...................pssts.W.RlsFlsGLlhushlht	.........h.uhhGGhLIGluuslLllhs......GRlAGIS.............GIluu.l.......lss.............................tts.hs..W..c....lhFllGllhushlh...............	0	101	209	276
+14084	PF14242	DUF4342		Domain of unknown function (DUF4342)	Eberhardt R	re3	Jackhmmer:B0C276	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 97 and 206 amino acids in length. There is a single completely conserved residue P that may be functionally important.	25.00	25.00	25.80	25.30	24.60	23.90	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.78	0.72	-4.21	24	177	2011-05-19 13:27:51	2011-05-19 14:27:51	1	2	141	0	62	144	7	82.10	31	52.91	CHANGED	Epppc.shsE..chpsoss-llpplKcllcKGNVpRIhlK+--.+sll-IPVsuGlhhGsI.u.sllhPhlshlGs...luAlsschTlEIp+	.....................pph.-phphssscllctlK-llcKGNVsRIhl+K--.+sll-I..Plsssl.hGs....l....u.slhhPh.lhhl.us...huAllschplcl.+.............	0	36	55	60
+14085	PF14243	DUF4343		Domain of unknown function (DUF4343)	Eberhardt R	re3	Jackhmmer:B0C6A8	Family	This domain family is found in bacteria, eukaryotes and viruses, and is typically between 127 and 142 amino acids in length.	28.50	28.50	28.90	28.50	28.40	28.20	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.71	0.71	-4.30	33	270	2011-05-19 14:59:22	2011-05-19 15:59:22	1	1	245	0	46	151	7	125.30	54	49.75	CHANGED	ppshFlKPsstsK.............tFsGpVhptsp.............-ls..........ths......s.......hspc.....p.lhlS-shp.htsEaRhallsucllssuh..Y.................+ss....hchcs.....-...scshppshphh.t.....hshspuaVlDluhsp.stp..htllEhNsh.uuGhY.uscstphlp	...........................................N.WGKFIKPKAGSK...............VFTGR...VVNsT+.............DLI..........GI.......G.......LPFD.....YPIWISEVVE.FIA......EWRCFVLDGRVLDVRP..Y.................................TGD....YHAQF........D.ASV.IDEA..ISCW.K........DAPIAYGLDIGVTR..DGR.....TLVVEVNDGYALGNY..GLSPLK...ohs........	0	20	36	43
+14086	PF14244	UBN2_3		gag-polypeptide of LTR copia-type	Coggill P	pcc	Jackhmmer:Q9SKR1	Family	This family is found in Plants and fungi, and contains LTR-polyproteins, or retrotransposons of the copia-type.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.86	0.71	-4.66	45	858	2012-10-02 13:37:57	2011-05-19 16:31:48	1	147	45	0	183	1298	0	123.20	19	15.91	CHANGED	uDsssh.Iss.h+L..sGsNYttWSpslphhlsuKsKhGalsGsl..stP.tpsD......acpWpppNuhlhuWlhNohssplhpshlhhssApplWcslt..ppappss...ssplhp....l+p..pltphp.Qs.stslppYasc.hhp.LW...-hpphp......hpsstsp	..........................................................................hL..st.p.N.Y..Wptth.hhl..tu.p.s.....h.h.....s.a...l..........s.......G....p..h..................P..................p........s....p................s..tht..pWptp.......sshl......h.uhl....h.sohs.p.l..h..pp...h....h....h..h.p.....o.up..ch...Wptlp..ph.a..sptp....tp.hhp.........lpt.....tl.thp..pt.t.pl.tah.th.....h..............................tt.......................................................................	0	20	109	161
+14087	PF14245	Pilin_PilA		Type IV pilin PilA	Eberhardt R	re3	Jackhmmer:Q59589, Jackhmmer:B0C6E0	Family	This family consists of proteins which form type IV pili. In M. xanthus these pili are required for social motility [1,2].	24.50	24.50	24.60	24.60	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.36	0.72	-3.52	48	287	2011-05-20 08:28:23	2011-05-20 09:28:23	1	8	84	0	98	303	30	100.80	20	62.61	CHANGED	pssKA+QSEA+shluulN+AQQuYhhEp..spFs........ss..lssLslsh........t..poppY........sYshsssss....................................sstt.......sssstssslpsYsuulhhsss...........ssssuslCcsssss	.............................t+u+poEA+ss.L.pulhpAQpuaahEp..spau.....................ss....hscluhss.................p....psspY..........sYplssuss.........................................h.......h....t..................................................s............................................................................	0	40	72	96
+14088	PF14246	TetR_C_7		AefR-like transcriptional repressor, C-terminal region	Eberhardt R	re3	Jackhmmer:B0C7Z3	Family	This family comprises the C-terminal domain of transcriptional regulators of the TetR family. It includes the AefR transcriptional regulator from P. syringae [1]. It is found in association with Pfam:PF00440.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.53	0.72	-3.75	164	1183	2012-10-03 00:15:22	2011-05-20 10:40:53	1	4	683	4	387	1012	42	54.30	26	25.21	CHANGED	GpLp.lsDsphAApQFhuLhcu.th.ah..plhs....sp....ss....tt-h....ppllcsAVchFLutY	............GtLp.hsDsthAAppahuLlpu.ph.hh..tlhu......hs.....ts.s..spch...cphscpAVchFLttY.................	0	84	213	288
+14089	PF14247	DUF4344		Domain of unknown function (DUF4344)	Eberhardt R	re3	Jackhmmer:B0C924	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 247 and 291 amino acids in length. There is a conserved EED sequence motif.	25.00	25.00	29.50	28.10	23.60	23.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.59	0.70	-4.69	33	149	2011-05-20 10:11:40	2011-05-20 11:11:40	1	5	108	0	52	149	25	172.00	24	70.55	CHANGED	Y..sspssptpphpchlppsph......hEshsshhssh.hhlPpslslth.ts...u-ssshYDP-spsl..plsYchlspshp...hFtp........ts..pssptht..cs....A.ls.s.hh.aolhHEhGHAhIshhplPllG+EEDAsDplAullLlph..s-..s..Gs.......hsluu..AshFthpucc..cs.pht-hs..........ahD-HSlDhQRaYshlCllYGSDPcpas.sLlc..cut.Ls..p-RA-hCttEYpplspsWppLLp	.............................................h.ttth.......p....ht..pt..h.hstsl.l.h..s...up.sshassptttl...hsYphh....t...hh.t..............t......tt.........s.hs.shhhhhhHEhGHhhlt..plPhhG..pEEDssDphAsh..hhlp.......p..ptt..........hhhs.s.st..ah.htt.tt..t..th..p..s.........hhstHuhchpRhashhChhYGussptht.tlhp......pht.h...pcRtthC..patthtpsW.phl.t.......................	0	8	18	36
+14090	PF14248	DUF4345		Domain of unknown function (DUF4345)	Eberhardt R	re3	Jackhmmer:B0CDG7	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 125 and 141 amino acids in length. There is a single completely conserved residue E that may be functionally important.	25.00	25.00	25.00	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.37	0.71	-4.67	33	186	2011-05-20 10:55:15	2011-05-20 11:55:15	1	1	172	0	55	174	304	121.30	22	89.27	CHANGED	cthhphhLslsulsslshGlshslsssshhsstsssssss.........hcuphRahuGhalulGlhhlhuhhphphtphshhhlshhhhsuGlGRllShhhsG.hPssshlsuhlhELllsslhhhhhtth	........h....phhlhlhuhhhlshGlhhhhsstthh.s.sh.s.ssthss.........shssphR.h.h.u.Glh..hGlGlhhh..h..ssh..p..h.phhshslhhlhhhhhssulGRLlol.h.h..cG.sP.tshhhshhshE...llhs..slhhhh....h...........................	0	16	36	46
+14091	PF14249	Tocopherol_cycl		Tocopherol cyclase	Eberhardt R	re3	Jackhmmer:B0C447	Family	This family contains tocopherol cyclases. These enzymes are involved in the synthesis of tocopherols and tocotrienols (vitamin E) [1].	25.00	25.00	25.40	25.20	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.49	0.70	-5.73	22	180	2011-05-20 12:58:36	2011-05-20 13:58:36	1	3	160	0	72	189	73	263.30	27	72.89	CHANGED	sRRFFEGWYaRVTLP.EhtpoFAFMYSIEDP.hG............GpsaSGGuAQILGssDpYlCRhFP-VcpFWAStt....tpLuluH.ttps.ph.sphLsPptFpcplppGYQsTsshpQGhItDsu......osphsRWpYphpPlYGWGs.sp.QpSTAGWLSahPIFEPGWQILMAHGLATGWIEWsGcpY-FpsAPAYSEKNWGGu.FPpKWFWlpCNsFpsp.sDLALTAuGGhRpVLhh...hEsVAlIGlHY.pG+..FYEFlPWs......uploWplsPWGpWphpAcNpp.apVclpusTp.ps......GTsLRAPT.pp...GLtahCRDThpGclpLpLhp..........ppsclIlcupSshuGLElGG	......................................................................................................................................................................................................................................................................................................h...................................uhhGhhu.hl.PhhEstWplh.hhtGh.us.Ghl.....phs.Gcpa-F..s..su...u..YsEKNWGtu.FPpcWhWl.Q.sNsFp....st......ssl....ulssuGuh.htl.hhh.......hcs.su..ll.u.l.ah..pGp..hYcF.sshs..................utl.....ph.p.l...p...s.h.u..p.Wplpu..p......s....pp....a.tlplpu.ps.p..p.......G.p...L...p..A..P..s..tp....sht...tsc-ohtGplplplhc.................psphlhpspo..phuulEhGG...................................................................................................................	0	30	57	67
+14092	PF14250	AbrB-like		AbrB-like transcriptional regulator	Eberhardt R	re3	Jackhmmer:A8ZQN0	Family	This family of DNA-binding proteins is likely to act as a transcriptional regulator [1]. This family does not include E.coli AbrB, Swiss:P75747, which belongs to Pfam:PF05145.	25.00	25.00	25.30	27.30	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.40	0.72	-4.07	31	183	2011-05-20 13:30:59	2011-05-20 14:30:59	1	1	74	0	80	187	216	70.60	55	54.51	CHANGED	sFhsALL-Ac....GlsLssps....supsptGRpsoYRloVQsNGNLLIGuAYT+pMsLpPGDEFEIpLG+..KH..I+Lh	.sFYcALL-A+....GlsLsssu......tupuptGRpsoY+soVpuNGNLLIGpAYTcphsLcPGDEFEIcLG+..Kp..I+Lh.......	0	12	53	71
+14093	PF14251	DUF4346		Domain of unknown function (DUF4346)	Eberhardt R	re3	Jackhmmer:B0BZ08	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 127 and 502 amino acids in length. There are two conserved sequence motifs: LDP and DHA. Many members of this family have been annotated as dihydropteroate synthases, however no experimental evidence can be found for this and Swiss:Q57571 has been shown not to possess dihydropteroate synthase activity [1].	25.00	25.00	25.10	25.20	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.45	0.71	-4.37	36	151	2011-05-20 14:28:43	2011-05-20 15:28:43	1	4	138	0	83	154	139	92.90	40	30.70	CHANGED	pslDcpLSpRaIsLDPuGYFlIhlD+csuhIsAcHasNsIs-+GLAsDPETGEslsC+G.psp.R.sssslapGRTAKELulplhEp.ppssPlopLDHAhYLGREhp+AEhsLlsGpcYlQD	...........................................t........................................................................h.h.........p.pspthhpG+oAKclh.plhEp..t.s.....lopLDHAsYLGRELt+AElALhpG.p.pY..lQD.......	0	20	55	73
+14094	PF14252	DUF4347		Domain of unknown function (DUF4347)	Eberhardt R	re3	Jackhmmer:B0CAL0	Family	This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important.	24.60	24.60	24.70	24.80	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-10.91	0.71	-4.75	113	300	2011-05-20 14:50:08	2011-05-20 15:50:08	1	150	158	0	134	354	204	155.90	31	6.72	CHANGED	pllhlDusVs-hppLlsulh..........s........ss........c.....lllLDsspDG....lpQIsphLpsp.....s.slsulHllSH.G.ssGsLpLGss.pLstssLsp..hssp...Ltphup..sL.stsu-lLLYGCsVAu..G.....stGppFlppLuplT.GAcVAASsshTGssthG.Gc.WsLEhp.sGs.lpssh......shsttshssYsulL	....................................................llhlDusVpchpsLlsulh............................s........ss........p.....lllL-sspDG....lpQIsphLpsp...........s.slsulHllSH.G..ssGplpL.Gs.........s...hLsts.sLts..hssp......Ltp..h..sp..........sL...stsu-.....lLLYGCslAs...u...................ttGppFlppLup...lT.GAsVAASss.hTGssthG.Gs.WpLEhp.hGp..lpst........hh.....tta..................................................	0	34	87	114
+14095	PF14253	AbiH		Bacteriophage abortive infection AbiH	Eberhardt R	re3	Jackhmmer:B0CCK0	Family	This family of proteins confers resistance to bacteriophage [1].	24.90	24.90	24.90	24.90	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.12	0.70	-4.79	44	409	2011-05-23 08:00:20	2011-05-23 09:00:20	1	3	336	0	51	289	12	245.00	19	82.16	CHANGED	LaIIGNGFDls.HGLpTpYpcFt.pYl.....................................ppp................................................cpp...lh...ct...lt......................chh...p..ttp.hWs-hEpsLu.cls.....hc.........................pp...............h.tth..p....chh.-..shpc........hhphp..p....pt.h.p.hh..phphpp...........hhp.chh.p......hphhp.....p................hhtpph...hp..ph...h..pppshF.loFNYTsTLEplYsls..pl.alHGt.pt................pplhhsHG.......st...pt...s.hh.........s.hs-c...................pchpptp..........h.h........tps...hh.phhh+shc....spthh.p..pppthhptl.s..sl.........pplhlhGaSluclDhsYhpcIhppl....sssph.hhhaas	................................................................................hIlGNGFDlt..a......GL....p........TpYp.-Fh..pah.............................................................................................................................................................tp.......................................................................pt.hh...p....l.......................................p.h.........t.p..tWsDhE.plu.phs....pp.....................................tp..............................................................h...h..p..p.hh..s..p.hpc................hhtht...p.....p...h..p.......t.ph.p.........................................hhp.phh.p............h.hhp.....p.............................................................h.htth......p..p...........pp.s.h.lsFNYT..p.s.......lp.p.h.ht............th...pt...................t..hhhHu.....p....p....s.hh...........s.hscp.............................................p...p........................pp.....p.hhpthh...........h.p.....p....t.l..t..s...........................p.lh.lhGhSl...ut...s...Dh.happlhpp.......ss...hh.......................................................	0	18	37	44
+14096	PF14254	DUF4348		Domain of unknown function (DUF4348)	Coggill P	pcc	Jackhmmer:Q64RZ7	Family	\N	21.10	21.10	21.10	21.10	20.90	21.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-11.78	0.70	-5.29	14	97	2011-05-23 09:07:11	2011-05-23 10:07:11	1	1	93	2	12	80	0	259.60	43	95.51	CHANGED	lhl.ulhh.LhlhsuCssp.psctcP.h.us..optlDSspscssDo.s...phlsEpPh.PtsADEhFDDFhFNFAuscKLQ+pRlpFPLPhY.pGcp.spcIcKcpWKhD.hFp+QsYYTLlFDpccpMchsKDTslsSVhVEhIaLcp+pVKpYaF-RhcGpWhLpuIshpsh..ccstNtsFlpFYp+FusDShFQtppl+pPLtFsssDPD.D-FshlpsTlsspQW.uFpPt.L.PpsplhNIhYGQK.s-.ospKIlsl+GluNGhps.LhF+++tspWcLhK	.......................................hshhl.lhlhsuCusp..psshDP.h.so..op.tl.DSh.t.pps-o.p....shlsEpPh.PtpADE.FDDFhaNFAusctLQ+pRlpFPLPhY....succ.....pspIcccpWKhD.hFp+QsYYTLlFDp-cpM-hstDTsL..sSV.VEhIalKp+hVKpYaF-RlcGtWhLpuIshcsh..cpst.NtsFlcFap+FssDShFQtpplppPLt..Fls.sDPD.D-FuhlpTTlshsQW.uFpPt.L.Pt-tl.NI...YGQ+....s-.SspKIlsl+GIuNGhps.LhF+.++sGpWcLhK................................................	0	5	10	12
+14097	PF14255	Cys_rich_CPXG		Cysteine-rich CPXCG	Eberhardt R	re3	Jackhmmer:B0C8L0	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 60 amino acids in length. There are 5 conserved cysteines which occur in a CPXCG motif and a DCXXCCXP motif.	25.00	25.00	25.10	25.50	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.99	0.72	-4.14	50	377	2011-05-23 09:38:52	2011-05-23 10:38:52	1	1	360	0	122	303	213	51.30	39	80.52	CHANGED	lsCPaCGcphclhlDsSsG.sQpYhEDCpVCCpPIphpl.pl.D.-s.phplplts-	.......hpCPaCGctlpl.hlDsSsG.sQpYhEDC.lCC+PIplsl.pl.D...ct..c.plplh.-................	0	34	63	97
+14098	PF14256	YwiC		YwiC-like protein	Eberhardt R	re3	Jackhmmer:B0C8C3	Family	The YwiC-like protein family includes the B. subtilis YwiC protein Swiss:P46909, which is functionally uncharacterised. This domain family is found in bacteria, and is approximately 130 amino acids in length. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	26.00	25.90	24.30	23.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.97	0.71	-4.06	64	369	2011-05-23 10:22:13	2011-05-23 11:22:13	1	1	357	0	79	307	2	127.30	34	50.68	CHANGED	lPsQHGAWuMlllPhlhGh.huu................shhp.lh............L..hluWhh..hYlhpaPh..hhhlKp.+p........ptp....ahph........h....hlY......u.....sluhhhslhslh.hps.pllhash.sh.lPLhhlshaastp+cERuLlN-lsullshulhuhs..ua.hh	.....lPpQHGAWsMlllPFlhGhhlus.....................P..shhH..l.............L..hluWhh..hYLssYPh..hhhlKp.+p..........pcc....ahph........sllY......h.....sluhlhulhsLl.hp..pllhash..shlPLhhVshYas+pKpERuLlNDluullshslhGhsuhh............	0	19	48	66
+14099	PF14257	DUF4349		Domain of unknown function (DUF4349)	Eberhardt R	re3	Jackhmmer:B0C5Q6	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 282 and 353 amino acids in length.  There is a single completely conserved residue D that may be functionally important.	24.40	24.40	25.50	25.10	24.10	24.30	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.40	0.70	-5.16	99	422	2011-05-23 10:50:48	2011-05-23 11:50:48	1	4	385	0	188	435	178	256.80	18	81.31	CHANGED	l..su.Cuusss............................s.............ss.......s.............tsssus........s..ss...sts.sutts.................................sss...s..ss....sss........ss....ss.......s........s...................p.p..lIp..su..sls..lps..ps...hspshsplpshspptu.Ga.lssps......p..t......tts.ssptpuslslRVPssph-shl....spl.p......s.l.....G.pl..pspshsucDVTpphlDlcuRlcshcspppRLhpLh.p.+As...slpDllplEppLuplps-lEulpuphchLpspluhSTlslslpp......t.ss....sp...s.....shh..sthtsuhpsuh....sshh....s....hhthlh....hhl....s.sllshhshl.h..lhs.h.ls.hhhh+	...........................................................................................................................................................................................t................t.......t.t..t...s................................................sss.s..ts.......sss.......ss....ss...........s........p....................................pp...llp..su..slp..lps..ps...lspshsplpshspph..s.Gh.ltsps...............t..p..................tsstptpuplslRlPs.s..phcshlsplp.......ph.....G..pl..p.scshpupDVTp.......phh.Dlpu.RlpshptpppRlhplhp...cAp....slp-.llplcpcLu...plpscl-phpuphp.lppplshuTlslshpp......................s......ttt..........sh....tthh....p.u.ht.tuhpshh....thhthhh....hhh....s.h.hlshhshh.h..hhhhhh.hhh.............................	0	92	150	173
+14100	PF14258	DUF4350		Domain of unknown function (DUF4350)	Eberhardt R	re3	Jackhmmer:B0C323	Family	This domain family is found in bacteria, archaea and eukaryotes, and is approximately 70 amino acids in length.	26.40	26.40	26.40	26.40	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-9.32	0.72	-3.77	163	383	2011-05-23 12:43:26	2011-05-23 13:43:26	1	4	379	0	148	374	7	71.10	21	18.23	CHANGED	sssssGs.tuhtp....hLpp....p...Ghpl......pthpp..s.hs...th..s..s................s....ss.....ol....lllsss..ht..hst...tphp.pl...hpalp..pG.s..plllss	..........sspspGs.tAhtp....lLps....p....GhpV......phhps...s..hp...ph..s..s.................p..ss.....oL....lllsss......t..hsp......tphp.tL...hphsc..tG.scllls.....................	0	44	100	136
+14101	PF14259	RRM_6		RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)	Coggill P	pcc	JCSG:Target_421663_WS20613B	Domain	\N	27.00	18.00	27.00	18.00	26.90	17.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.50	0.72	-9.07	0.72	-3.99	76	8811	2012-10-02 20:46:34	2011-05-23 13:46:14	1	359	393	72	5363	52886	951	69.90	20	16.00	CHANGED	lhlpsl.s....s.sst.pclhphhst....h.s.p.....l....p.slphh....t..p..............pst..Ahlph..s...stp.sAppshpp...h...p...hh..l..ps+hlc	..........................................lhlpsL..P..h......s..s..o....p....p....-.....l........t.....p....h....F.p.p..........................h..u..........................l..............p..sl...p..lh.....................h......s......t...t.....................................pu...h..........A.a.......V..........p....F.........t.................s..tc....p....Ap...p...A.l.pt......h......p....h......h...tsp.l.................................................................	0	1680	2599	3942
+14102	PF14260	zf-C4pol		C4-type zinc-finger of DNA polymerase delta	Wood V, Coggill P	pcc	Jackhmmmer:P30316	Domain	In fission yeast this zinc-finger domain appears is the region of Pol3 that binds directly to the B-subunit, Cdc1 [1].  Pol delta is a hetero-tetrameric enzyme comprising four evolutionarily well-conserved proteins: the catalytic subunit Pol3 and three smaller subunits Cdc1, Cdc27 and Cdm1 [2].	24.00	24.00	24.20	24.10	23.20	23.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.34	0.72	-3.97	123	623	2011-05-23 13:01:37	2011-05-23 14:01:37	1	15	346	0	405	635	5	74.40	35	5.48	CHANGED	Cl....s.Cc.s.lppt................slCppC.t..spp....sslh.phhschpphEp+...hscLhshCppCp..............ushtpplhC.sSpDCPl.FYpRt	.................................................................................Cls.C+s.lpptt......................slCspC..p....spp.....splh.phlsclppLEp+ascLhotCQpCp.................Gohc.p-VhC.sS+DCPl.FYhRh......................	0	141	227	345
+14103	PF14261	DUF4351		Domain of unknown function (DUF4351)	Eberhardt R	re3	Jackhmmer:B0C7B5	Family	This domain is found in bacteria, and is approximately 60 amino acids in length.	25.00	25.00	25.00	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.12	0.72	-8.76	0.72	-4.10	123	513	2011-05-23 13:20:27	2011-05-23 14:20:27	1	8	115	0	203	604	76	61.60	34	25.98	CHANGED	p-Gc....pc....................tt....t.sLlLR.LsRRhGplssp......ppIpsLSlpQLEsLu........EALLDFsslsDLpsWL	.............................................pGhpc............up....tpLllR.LpRRhG.plssphp....ppIppL.s.l.ppLEsLu........EuLLDFssl...pDL.tWL.............	0	62	162	200
+14104	PF14262	DUF4353		Domain of unknown function (DUF4353)	Eberhardt R	re3	Jackhmmer:B0P678	Family	This family is found in bacteria and archaea, and is typically between 262 and 279 amino acids in length.	25.00	25.00	25.60	25.00	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.05	0.70	-5.18	51	568	2011-05-23 14:50:37	2011-05-23 15:50:37	1	12	299	0	137	543	7	204.70	25	61.88	CHANGED	Glslsus....s.V.TIosuGTYhlSGohs..sGQIlVsA.sc...scpVpLlLcGssIosossusIhVps.AcclhlsLu-GTpNoloD....uupas........tsspssAAIaS+sDLTl.sGsG.sLsVsushssGIp..S+DsLhIsu.GThsl....sA.scculpGKDuVpI.....ssGs...lsl.sAssDGl+Sc.....N--D.....sscGhlhIsGGslTIsAG.sDGIpAssslhIsGG.s....lslss.......................uscGlcutt.l...slsGGslslssu...DD..Glpust.........................plplsGGsh..slsuuc...DGlc	.............................................................................................................................................................................................................................................h.s...h.h.....t.......s...l....lt.u...t...tp...ul...sp.....s.s......lhlt.s..G.....s..h..pl.....p.u....s.....tcul.....pup....s....tlpI............psGs.....hsl....su.......s....s.......D...ulcus...............ttp.p...........................tt.G.h.lhIsG.Gsl....sl.........s....u...u....s......D.....G.lcA.........s.........ss....l.hIsuG.s..........ls..lps.............................................................u.cGlcu..t.slslsGG..sls.l.us...sD....ulpus.......................................................st...............................................................................................................	0	82	123	133
+14105	PF14263	DUF4354		Domain of unknown function (DUF4354)	Coggill P	pcc	JCSG:Target416839_SP17692A	Family	Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop) proteins, but this could not be confirmed. The one PDB:3NRF structure solved for this family exhibits an immunoglobin-like beta-sandwich fold.  Crystal packing suggests that a tetramer is a significant oligomerisation state, and a disulfide bridge is formed between Cys 125 at the C-terminal end of the monomer, and Cys 69.	25.00	25.00	25.80	29.00	24.90	24.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.57	0.71	-4.43	10	100	2012-10-03 03:07:29	2011-05-23 16:13:37	1	1	97	3	13	46	1	121.80	51	96.22	CHANGED	MKp..thhluulALsuh....shsAsAsssDslhVaATppopGolSlGc+shYTKsFcVsVsNhucpsIDLsph..Ch+AauscG+cF+lDTVDEcLspGoLKsGpsVKGhAVFAS-scSVYpAshVKlSss	...........hKp..hhhhshluhsuh....sShApsAussslMlhATscopuus..SsGDKsFaoQTFDluVANsuuoDI...sLcKl...CFlAluscGKoFssDTIDpKLToGlLKsG-SVKGFAsFAusDcSlYcsplVKhS-.s.......................	0	3	8	11
+14106	PF14264	Glucos_trans_II		Glucosyl transferase GtrII	Eberhardt R	re3	Jackhmmer:B0P6U7	Family	This family includes glucosyl transferase II from the Shigella phage SfII, Swiss:O21944, which mediates seroconversion of S. flexneri when the phage is integrated into the host chromosome [1].	25.00	25.00	27.00	27.00	24.00	21.20	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.36	0.70	-12.26	0.70	-5.43	56	371	2011-05-23 15:20:29	2011-05-23 16:20:29	1	1	254	0	42	303	10	302.20	21	64.26	CHANGED	hhshlhsshhh.hD-....stsh.h....uhtsW..........hp...GR.hhphlhphh....hpsh....hsh.s.hstl...Luhlhluhuuh.ll...sp.hh...shp..........p...phh.sslhshh.h.hssPhhl.pph.uapasuhthululh.husluhhhh..........p.............pp...p..h.thlh.uslhlh.huhshYQuhhs...lalslhlhhhlhph.............l.csp.....tshpthhh.tlh....p.lhh..hlhuh..slY..hlhhplh..hhhh.psphssh..t..spht...h...tshhps.lhpshpph..hphht......t.sh.hhhh..hlhlhllhhlhh..hhhhhtpph.....p...t.h.thhlh.l.lhhhhhP..hhh.h.....lhlh...hs.s.......shhps.........hhshshs..h.hh..hhh.llh	.......................................h.hhhtsh.h.lDD....t+tht..........uhtsa..........sp...uR.h.phlphhh....spth...hsh.shh.s.l.....Luhhhlulssllh...hh.hh.....stp..........p....shh..shlsshl.hhhs.PhFl.psh.uFpasu.hhululh.huhlshhhh..........p..................ps...p..h.hhlh.uhlhlh.hhhshYQushs...lalslllhh..hhhpl.............l.ptp.......htthhh..hhh....t.hhhhlhuh..lhY..hlhhph.........ss..ptsth..ts.tpht....h...........tch.ps.lhpshpph......hp.hht.........psh...hl..hll..h....h.llhllhh....hh.thhp.p......t.....hh..thhhh.l...lh.lhlss..lh.h...h......lhlh.....hsp........hhts.........h.tashsh.sh..hhhh..h...................................	0	14	20	26
+14107	PF14265	DUF4355		Domain of unknown function (DUF4355)	Eberhardt R	re3	Jackhmmer:B0P709	Family	This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 180 and 214 amino acids in length.	24.00	24.00	24.10	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.81	0.71	-4.17	85	633	2011-05-24 07:17:12	2011-05-24 08:17:12	1	2	519	0	57	462	6	126.50	21	66.38	CHANGED	ppp.pt...cphscp-.....lschls..............cphpchcpc.....pp.....................Eu...........c+...l.uchss.c-.......+.tc.....h-hcph.......pc.......cl...pchctphpppchp.....spspphLs-pul..sss........hhs..hl.........l..ss..DsEp....sppslcsh...pph....hs...pslpptlc.cp....l+us	........................................p......pphsppc......lsphlp...............cphpphcpc..tpct...................hp..Es...........ccl..sc.hst.cc........c.tp.......hchcph.......cp........-l.......pph....cspht....ppchp.....sps.pphls-tsl...sss........lls..hl.........l..ss..ssEp....scpslcsh...pph.......hpphlppthp.tthpt...................	0	17	36	47
+14108	PF14266	DUF4356		Domain of unknown function (DUF4356)	Eberhardt R	re3	Jackhmmer:B0PD80	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 540 amino acids in length.	25.00	25.00	25.30	26.40	24.80	24.30	hmmbuild  -o /dev/null HMM SEED	488	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.85	0.70	-12.67	0.70	-6.09	10	232	2011-05-24 08:09:00	2011-05-24 09:09:00	1	3	178	0	31	192	2	426.50	34	89.65	CHANGED	sps...hsasplAsRlLGsPp....Dcs-YaNpLacLpps.pshphhpppLcKpIsscc.h...QclpcIHs......lspcp...oVs+hlAaLsucpll....s+cssslh+Rpl+pAhhpVl..E.ha...+cp.sLs+s....c..s.....hlVcLls...Wlpsalsphhcshchc...cphPKVVWYG-sscSplYFLaaLhhlGCDVLlFHP..s.pscDsFpcsD.E.p.h.hl.hphs.sossLEPFPsEc..sRpuTV.AY+uo+ElEplLas.DSul.YKPWQF+casPhoVTLKTTYDELFllsKE+AhlRPsFcsscs.oVsIPNlFAKIsGVoc.DppEYWs+l+sLt.s.p-Tphlps.FP.FTcpp..puNap.aapcsls...csGcIcs-cLhpSslWpYpcLs-GlQcuIAcsIpchCcpPhlK...tE..p.spD.ltlalFsQlsplssslLcLIQsFDYoQslPKlVlYpo-psspLoRsDAssLlFLNclGlDIllYNPsGapsIEpYI-cstFDsHaL-EhlFsLpa+EsSt......ppll+KLF	.............................................................p...htashlhsRllGl.p......D.s-YhscLachsp....s.h....t..t....h....hpt.pslsc..sIsscp.h....pc.l..t.l+p..............tt.pt........sss..ch.lupLssppLl....hpss..cLt+h.l.+psFhslL..cla.....ccp....p.ppl.....K..s.....Fhlchlp..h.ppalsphhpshshc..........cphP+IlaYG-..hp.csclYFLhaLhhlGCDVLYhpP........c.sc-sapp....l......Dpctp.h..hh..h...phs...tphslpsFP..ccc......p.RhuTl.AYpAo+EI-plLaptsShlYKPWQFcsass.shTLKTTYDElhllhcEcAhlRPsFhspsp..plhIPslFAKIsGVpp.spc-Yapclcslt.s..pso...h...hl......pshP..ascpt....psshp...pYp.ph..ls....................ptGplc.-hlhpSpha..appLspslQptIhctI.chhcp.hhh.............................p..p.pp-..htlhlhtpl.pls.plLc.lppFDYspplPKlllapspps.plo+pDuhlLhFLNplGhDlhhasPsGhssIE.aIp...tthaD.HhL-chsas.phpt.s...........hhptlF.................................	0	12	24	26
+14109	PF14267	DUF4357		Domain of unknown function (DUF4357)	Eberhardt R	re3	Jackhmmer:B0PED6	Family	This domain family is found in bacteria and archaea, and is approximately 60 amino acids in length. There are two completely conserved residues (G and W) that may be functionally important.	25.00	25.00	26.10	25.20	24.10	24.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.51	0.72	-4.37	54	287	2011-05-24 08:19:50	2011-05-24 09:19:50	1	13	270	0	82	286	23	52.60	34	16.61	CHANGED	RppLlssGll.tt.ps...sp.hlFscDhhFs.SPSsAAullhGpssNGhhpWK.stsGpTLc	......................phhtpthl......t..........tt.hhhscDhhFs.SPSsAA.shVlG.p.o.sNGhspWK..stpGpoL.........	0	37	65	72
+14110	PF14268	YoaP		YoaP-like	Eberhardt R	re3	Jackhmmer:B0PGJ1	Family	The YoaP-like domain is found at the C-terminus of the B. subtilis YoaP protein Swiss:O34983.  It is found in bacteria and archaea, and is approximately 40 amino acids in length. The family is found in association with Pfam:PF00583. There is a single completely conserved residue A that may be functionally important.	25.00	25.00	30.30	29.10	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.11	0.72	-4.73	37	211	2011-05-24 08:34:33	2011-05-24 09:34:33	1	4	169	0	37	184	5	43.80	38	17.89	CHANGED	PlphI+lcohEcApssPssFssaulFYsGcFlTscl..l.scppFcK	........hphIcl-ohcpApssPssaTsaulFYsGcFlTscl..h.spp+hc+..	0	22	32	34
+14111	PF14269	Arylsulfotran_2		Arylsulfotransferase (ASST)	Coggill P	pcc	JCSG:Target416597_Pfam-B_1234 (release 25.0)	Family	\N	27.00	27.00	27.00	27.30	26.60	26.80	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.97	0.70	-5.27	23	447	2012-10-05 17:30:43	2011-05-24 10:41:10	1	8	258	0	240	647	295	268.60	28	56.51	CHANGED	+sQhLpspsVlsaWsGshht..hGaGaGtlplLssoYppIapVTlsss....aho..-.psh.SalDhHEupl.oscGTllV..ouhNlTptDLpslGG..p-sahhDuhhaEIDIpTNcllFcWSAl-Hlsplslp..........up..tslsssssspcpPa-haHlNSV...........spas-.sYLlShRahsSlahlp.ps.......GsVhWplpG.pG.GDFph..sss..FsaQHDsRlhppo.....c-shslSlaNN.......sNosh.......ststsTTGllhslDhp.s+psohh+plh........sspcsltSsoQGsaQlLss........uHlllsaGshs+.lcEaDssGplVhp...spFG	.......................................................................................................................................h.......................................................................................th...h..c...hH-hp.....h...h...ssu.s.h.Lh......ss.h.p.......h...t.........D....l..s......s...h....GG.........s....p....p...G......h.........l.ssl.....h...............p..................El.......s...h...c....G....-lla-.Wpuh-Hl.s....p.c.h..................................................h.ts...h..........................s.....t.hcahHINul................sh.s.p.-......G....p...h.L.l.ShRpssulhhls...t..po.................G.cl........lWch.....t.......G....................................................................t..........s....h...u................Q....H.sschh............................ss..s..sIhlFDN..................us..h.........tssss.s..spu...h.....l..l..c.l.D..........p.........pths..h....h.cph.h..............................sss...h...hSs...GusQ.h.LsN...........................GNshl.......s......ush....ut...lhEhss-G..c..slhch...h............................................................................................................................................	0	43	114	194
+14112	PF14270	DUF4358		Domain of unknown function (DUF4358)	Eberhardt R	re3	Jackhmmer:B0PFB1	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length.	25.00	25.00	25.30	25.30	21.90	20.60	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.17	0.72	-4.16	55	201	2011-05-24 09:45:12	2011-05-24 10:45:12	1	3	148	0	17	159	5	106.10	19	57.92	CHANGED	pplppsss.....h.p..phpchssptlcph..a.slssschcshhhhtust..sspssElhll+sp-sp.scsVcsslpp+lpsppps.acsYhs..-..phphlcsuhlpp..cGsYlhhllup	................................t....tsh....h....phpphs...sptlpph..a.uls.sthpshhhhhsh...shpss-lhlh+sp-tcth-slcpslppphcspppp.apsYhs...c..phphl.csutlps..cGsalhhhh.............	0	14	16	16
+14113	PF14271	DUF4359		Domain of unknown function (DUF4359)	Bateman A	agb	Jackhmmer:B1XKA9	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 130 amino acids in length. There are two completely conserved residues (P and S) that may be functionally important.	27.00	27.00	30.00	29.80	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.16	0.72	-3.67	39	182	2011-05-24 11:53:38	2011-05-24 12:53:38	1	2	174	0	36	127	19	107.00	39	71.17	CHANGED	usshshTNPupp-YppaAuppLsph..hpp-lCt...pphshhLt........hhpsCspLlsst..pstltpllsptTpRpNahlFSlYpT-lshps.......hstaphp..TlGlhspFhshpsp	.h.lhLA.oNPo+s-Yp-aAucphhpp..ls+clscs..csppu.hLss.......lsussc+Lscph...scPplshlI-phT+RssYlhFSsYpTEaclss...............pY+al..slGhuphFlsl-h.s...	0	8	23	32
+14114	PF14272	Gly_rich_SFCGS		Glycine-rich SFCGS	Eberhardt R	re3	Jackhmmer:B0P5U8	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length. There are a number of highly conserved motifs including an SFCGSGGAGA motif.	27.00	27.00	144.60	144.40	26.40	25.20	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.43	0.71	-4.21	9	314	2011-05-24 12:25:02	2011-05-24 13:25:02	1	1	314	0	37	103	2	114.80	81	95.98	CHANGED	lpVVIGDRLGKGppVAKGVEpAGGpAlVIPGMGADMKLGDVMppEsADlGISFCGSGGAGAlTApTKYGY.s+aGMRSV-EGVTAIp-GppVLGFGFMDpEELG+RlsEAahKKa	...ITVVIGDRLGKGQKVAtGVEpAGGRAVVVPGVAADMKLGDVM+uEsAsFGISFCGSGGAGAITAQsKaGYKAKYGMRSl-EGVTAINEGssVLGFGFMDKEELGcRLVpAapKKa..	0	4	9	23
+14115	PF14273	DUF4360		Domain of unknown function (DUF4360)	Bateman A	agb	Jackhmmer:B1XRI1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 200 and 228 amino acids in length. There is a conserved GCP sequence motif near the N-terminus.	27.00	27.00	33.10	32.00	26.40	25.10	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.37	0.71	-4.63	14	198	2011-05-24 12:27:51	2011-05-24 13:27:51	1	4	87	0	146	193	13	174.30	29	79.62	CHANGED	sspplpIhssshuGoGCPpGosus..slSsDpT....hhohuFDpF.s.lGs...Ghs.ss-ppKNCpLclsLp.aPuGFQaull-usY+GaApL-tGlTGohhooYaFSpssspsss...........oppohpGs...hpG.sYshp-plsssuhlaSsCG...ssu.Ls.INsplsL...Tu.ssusssGphopDsssls...hsQplpltW+.......sCs	...........s.stplpItssshsGoGCPpGosss..slosDpo.....shTlta...s.pahAp.hGs...sss.ss-pRKNCQLslslp.hPsGa.pau..lhs.s-Y+GaA..pL..ptGsoG.s.pusYYFsG.tsppss...........sppshs..GP....hss.saphpDpssh....s.s.....hhWSPCG......sps.LN..lNsplpl.....su...ss..tp.s...tuh.hs.Dshsss...hpphhphtWppC................................................................................................................	0	54	101	127
+14116	PF14274	DUF4361		Domain of unknown function (DUF4361)	Coggill P	pcc	JCSG:Target_416718_SP15308B	Family	\N	25.00	25.00	27.20	26.40	24.90	23.40	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.08	0.71	-4.58	20	68	2011-05-24 13:04:20	2011-05-24 14:04:20	1	1	29	8	8	59	0	161.40	39	48.06	CHANGED	YpKALL+lhPFNDYSGsYSuTsh..pla..h.sGs......spshstss+puaVVD-pTIFFYAGhlsE-h..pDRcpYKlhhpF.........s..pc.........t......slplpss.ssssslpFcl..........hs..psoYplspphDss+PYLc++alolp.lsYcasDhTos....Puh.lpY+VcGohoMpRpI.NTpIPD	..YpKALLRlhPFNDYSGsYouosh..pla..hpss......ssshspss+pu.aVVD-pTlFFYAGhhsE-h..pD.RcpYKIhhpF.........s.s-.................s......slslpss.sssschpFcl...........hs..sPoYplspphDsspPYLcH+alsIp.hsYpasDhTos.....sh.lpYcVcGolohpRpl.NTpIPD..........................................	0	7	8	8
+14117	PF14275	DUF4362		Domain of unknown function (DUF4362)	Eberhardt R	re3	Jackhmmer:B0PHJ6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 93 and 146 amino acids in length. There is a conserved IRIV sequence motif.	25.00	25.00	25.40	27.70	22.90	24.30	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.32	0.72	-3.95	8	109	2011-05-24 13:06:54	2011-05-24 14:06:54	1	2	92	0	9	83	0	89.60	44	60.27	CHANGED	KKNDVVVK.GstISNLDKFEpFVlNV-QGcVDKIRIVpYTcEGDPIFQTLEaSGpDIlYV.DNRpschhAGcpKGLaKDSCKSIVK.EQREsposYRLI	....................psD.ll.p.tst.l.Nlc+h-pFlhNl-pscs...DcIRIVpYTpEGDPIFQsL....Easu....p....cIhYshDsRcD.p.FsG.cpKsl..h..KDSCKpIVK.cp+EstssY+Lh...............................	0	5	8	8
+14118	PF14276	DUF4363		Domain of unknown function (DUF4363)	Eberhardt R	re3	Jackhmmer:B0PHJ0	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 120 amino acids in length.	26.40	26.40	26.50	27.50	25.30	26.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.58	0.71	-10.21	0.71	-4.41	34	185	2011-05-24 13:21:49	2011-05-24 14:21:49	1	1	150	0	49	144	2	115.50	22	93.11	CHANGED	hlslhlhll.llhhshastphltpsspclppplsplpptlcp.pcapcAtpphpch.ppWpcppphhslhlsHpElDsIshpls+LppalppcspspuhuplptlKhhlp+lhctEphslpNI	.............................h...hhlhhl.llhhshh..phltp...t..s...cplp.pp...lsplppplpp.ccWppAtpphpclpppWpchppthshhlcHp-lDp.lshslt+lppalpscscstuLuplphl+hhlppl.p.p..plpNI...............	0	26	44	47
+14119	PF14277	DUF4364		Domain of unknown function (DUF4364)	Eberhardt R	re3	Jackhmmer:B0PBH9	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 180 amino acids in length.	25.00	25.00	25.00	26.20	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.74	0.71	-4.63	61	224	2012-10-04 14:01:12	2011-05-24 14:37:29	1	1	223	0	42	169	12	161.20	32	91.48	CHANGED	hKLllLYhLc+lchPLoNsQlochlL-psassYFpLQpslsELhcushlphc..pcspshYplTcpGccsLphFpscIspslcccIcpalp.p.p.hph+c.-ss.lpuDYh..p.sssspYh.VchplhEs..sssLl-LpLsVPsccpActlCspWcpp..sp-lYshllshLh	..............KLllLYlLc+lchPloNsQlochlL-.ppahNYFpLQQhLsELhcushlphp..tpspp..........hYplTccGccsLphFts+Is..tshhcclcpalppp.t..pl+p.Esplhu-Yh..t.pssspah.VphplhEs..spsLl-LplsVsoccpActICspW+pp..up-lYshllptLh.........................	0	27	38	40
+14120	PF14278	TetR_C_8		Transcriptional regulator C-terminal region	Coggill P	pcc	JCSG:Target403231_MJ9673J Pfam-B_17743 (release 25.0)	Domain	This domain is a tetracycline repressor, domain 2, or C-terminus.	27.10	27.10	27.10	27.10	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.33	0.72	-3.60	44	1050	2011-05-24 13:50:59	2011-05-24 14:50:59	1	4	678	0	160	662	5	77.60	21	39.73	CHANGED	thh.hpplhphltcppchhphlhstp.tsssa..hpplpphhpphhhphhppthhptst........hh.hpahsuGhlullppWLp	............hhpplhpalt-Npcah.+sllpsp..tsspa....pp+lpchh..p.pp.h.h.p.h..h..s.htp.ptsh................hh.hsahsuuhlulIphWl..............	0	55	104	138
+14121	PF14279	HNH_5		HNH endonuclease	Bateman A	agb	Jackhmmer:B1XMH2	Domain	This domain is related to other HNH domain families such as Pfam:PF01844. Suggesting that these proteins have a nucleic acid cleaving function.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.95	0.72	-9.55	0.72	-3.97	15	136	2012-10-05 18:28:12	2011-05-24 16:05:27	1	1	131	0	21	135	168	68.00	50	23.01	CHANGED	CIlC+c-hscpshs..-EHVIPsoIGG.....ph+hps.lCcpCNscLGpslDsplscphh......phhpthhcIcpc+Gpss	............CIICR.....KDTKE.LS.......EQ.aVIPEILCG.....aYF.T..NS...I...CD..oCpEpho....TNIDRPLIRHKLu...........hKIEpMKtp..hp.s....................	0	5	11	15
+14122	PF14280	DUF4365		Domain of unknown function (DUF4365)	Bateman A	agb	Jackhmmer:B1XQ96	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 182 and 530 amino acids in length. There is a single completely conserved residue D that may be functionally important.	21.90	21.90	21.90	22.60	21.80	21.60	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.69	0.71	-4.46	68	263	2011-05-24 15:26:30	2011-05-24 16:26:30	1	15	243	0	94	248	14	142.10	19	38.93	CHANGED	pptuhshlpth........hsph.salhc...psptDhGlDu........lEl....hs...ssp....soG..thls...VQlKuspshh.................psstshphthp........ppchsYWhp.tslPVllV..lhssssp........pha......Whplppthh.........sppptplplspss.hhsspshsplhphsttt	...........................p.u.shhpth........hspt..shhhp....ptptDh.G..lDsh.....lch.............hs......sup.............ssu.....hhls...VQlKsss..shh.........................ssssshsh..hp........spclsahhp..pslPl..lLV...lhssssp................psY...............Whplpspshp....................sppphplplshpp..hsstshpplhp.h..sh.......................................	0	24	59	79
+14123	PF14281	PDDEXK_4		PD-(D/E)XK nuclease superfamily	Bateman A	agb	Jackhmmer:B1XMR1	Domain	Members of this family belong to the PD-(D/E)XK nuclease superfamily.	21.80	21.80	21.80	21.80	21.60	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.33	0.71	-4.42	92	355	2012-10-11 20:44:47	2011-05-24 16:36:41	1	7	324	0	99	367	61	175.10	18	46.51	CHANGED	hNlFplhph..........EhtpSshluaLLsPp...ts.........HshsshFlctal.chhttptt..p...................................hpshpVp+E...............ttp..+lD..lhl......pssph....hllIENKlh.....up-pp....................s....QLpcYhp.....hlppch..................................tttphhhlaL............psssppshss..............................t.tahtlsa.......pplhpaLcphhpp.......tttpthpthlppYhp	............................................................................shaphht.............E..pothlshhls.p......tt...........Ht....t..t..a..lphhl.chhttp....t.......................................hpphplppE...............................tttp...+lDlll..........pssph...................hllIENKlh.......up-pp........................s..........QLpcYhp.........hlppph..................................t.pphhh.laL..p..t..............ppssp.shtp...........................................tahhhsa.......tplhph.lpphhp.....................h.....................................................................................................	2	34	64	86
+14124	PF14282	FlxA		FlxA-like protein	Eberhardt R	re3	Jackhmmer:B0PBA7	Family	This family includes FlxA from E. coli, Swiss:P77609. The expression of FlxA is regulated by the FliA sigma factor, a transcription factor specific for class 3 flagellar operons. However FlxA is not required for flagellar function or formation [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.11	0.72	-11.15	0.72	-4.09	18	424	2011-05-25 07:16:36	2011-05-25 08:16:36	1	2	376	0	79	227	8	98.60	31	75.65	CHANGED	SulS..uossSoo.tsusss....supIppLppQIpsLpcpLpcLsss...psh.os-cK..p...pQpphIQsQIptLQAQIuQlQpQpupcsppp....pppsh.p.....spssss-GsNp.Pos.ssp	....................ssh......potsSsp..tStsss........supIsclspQIppLoppl.p.clss........suh.os-pK...p...cQtpLlQpQIphLpsQl.....u...QL.QpQp.A-Ktpcp........ppt..........................h.......................	0	12	40	57
+14125	PF14283	DUF4366		Domain of unknown function (DUF4366)	Eberhardt R	re3	Jackhmmer:B0P8U4	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 227 and 387 amino acids in length.	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.74	0.70	-4.92	37	374	2011-05-25 08:16:00	2011-05-25 09:16:00	1	13	188	0	39	339	46	197.90	28	65.93	CHANGED	Rhh.u.A.LsAu.l.lls.GFossAaAtGs-ssst........hssss.t......s....c.......pcstslTP-GNhsLVDDh....sst..ssKQFITlsTKuGNhFYllIDRs.sc.s.c......s.VHFLNtVDEADLhALhE-tpst..s.............................thtps.........pspst.p.........p................................cP.Ec.................c.s..shus.....lhllLllu.....l.hGG.GAh.aYF.Khh+sKpppp.s...ssDh.--.hD.hs-..........-p.pp-Dtss.s--	......................................................................................................................t....................................................t.s.h.o.spGs..h..t..hhDch.....................t....ss+QFIThpTKsGphFYllID+spp.sc......s.VahLspVsEsDLhsh..hEctptt.t................................t...phpcsst......t.psc..p.tp........tp......................c...Ec............pu..shGs...hl.ll.llls.h.suu..GAh.YY.FKlhKs.Kpc.pp.t.....cpD.h.-p..h-...s-.....p......-p.-pp-t.t.t..pp............................................	0	25	36	39
+14126	PF14284	PcfJ		PcfJ-like protein	Eberhardt R	re3	Jackhmmer:B0P892	Family	The PcfJ-like protein family includes the E. faecalis PcfJ protein Swiss:Q5G3N2, which is functionally uncharacterised.  It is found in bacteria and viruses, and is typically between 159 and 170 amino acids in length. There is a conserved HCV sequence motif.	25.00	25.00	25.00	25.00	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.01	0.71	-4.76	32	550	2011-05-25 10:31:24	2011-05-25 11:31:24	1	2	378	0	44	395	28	152.40	26	36.54	CHANGED	hWpDYlchhcchtp.Dlp..ssthlpPpsL+ttHDchhtchpthpcccctpchpc+hhc.pthh.c.lKt.+a.....pFoDsplhlpVhcSlp-hhpEGpsLHHCVs...s.ptYh...t+tcohIh.hRhcsc.hE...TlEl..p.csh..VlQsRGhpNp.....sschp-cIhphlpp.tphIppRh	...................................................................................a.Dhlphh..h...t...hp..p.....hhP...s..h..tHD.h.t..php..p...........p.p.p.tp...........p.....ch..p....................hp....h.................hp.s.th.....hhs.cohpEhhpEGpthp.HCVu............u..p.Yh....tptco.hIhShR.h..p.s..p..h..c........TlEl.........s....ps......h....plsQh+GhpNc.....p..p.chtccllsllpp..t.h.....................................	0	18	35	42
+14127	PF14285	DUF4367		Domain of unknown function (DUF4367)	Eberhardt R	re3	Jackhmmer:B0PHJ7	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 229 and 435 amino acids in length.	25.00	25.00	25.10	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.12	0.71	-4.93	52	440	2011-05-25 12:10:07	2011-05-25 13:10:07	1	11	247	0	86	388	10	174.10	15	56.36	CHANGED	hhp.+htshhhsshlh...hhss.........sh..ssp..Ahpttlh..p.hl.hphhs...phsphphpspptp............................c.....phthp..hp.s.......YlP...cGaphp..........p....hp...hss...t....hp.....hh..haps...sss.phhpa.pppth..p...s....tsh.sh...ssE....ss....ph..cplpl..s.G.......hp.uhh.hc..p.ps.........pph.......lhWpppshha...pl..t.......us.ls.......p-EllKlscsl	.......................................................................................................................................h..........hh.h...................h...........t.....hh..t...h......t...............h.hp.stt................................................................................tpht..t.htht..hhtss.hlP...c.G.hphp.....................................s..............hps...s.........hp...........hh..haps....p.pt..thhhh.t.tth...s....p..........tss..sh.ssp.....ts.......ph..cphpl...s.G........pc.uhl...hp....pps.............pts............lha..pppshhh...pl..t........usls...........c--hlclscol....................	0	50	74	77
+14128	PF14286	DHHW		DHHW protein	Eberhardt R	re3	Jackhmmer:B0P7B6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 404 amino acids in length. There is a conserved DHHW motif.	25.00	25.00	25.40	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.30	0.70	-5.14	8	368	2011-05-25 12:28:32	2011-05-25 13:28:32	1	3	220	0	48	338	15	202.40	15	68.82	CHANGED	EKRcLAcFPsFShpuhhDGSYFcDlupWYuDTaPhRDtFluhsAshcpLYGlch.sssclhussstptpDts.-sspsssspsh.s..sssspsso..........................sSsspsuospsss.sps.ps..sDsss.pshh-t.........shhpsphtsslalhsspuapLYsFsp-sucpYAuhlNshspcLs.sls.VYDMllPTuhslhLP-s.hpc.h.sousQcpAIsYhYuhhscsVKpVslY-pLtsHs-EYIYFRTDHHWTALGAYYAYpsFscstGlsshsLScacKc-hssFlGSaYutTpps.uLcpNPDTlpAYlPhsTNshchhss-us..pachlh.s.s..casuuspYSsFlGGDsslscIpNPslpDGSsllVlKESYGNAFlPFLV-HYppVYVl	......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.h.t..........t.h...t........lph............t.....h.....t.......t.....t.c......l...Ya+TDHHWs..G.....A.......ahuap..........hh..........p....t......h.......t............p.............t........p.........p....h..p.........................t......t..h........hGs........h.tt...........h......t..-...h.....h.h........t.............t.......h.........................p................................t..........h....h......p...........t.........ts...Y.t...h.ah.ts.s..s.h..l...ps.....t..........s...........t.....p..hllh+DSausshhshhh..atph............................................................................................................	0	32	45	46
+14129	PF14287	DUF4368		Domain of unknown function (DUF4368)	Eberhardt R	re3	Jackhmmer:B0PC15	Family	This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF00239 and Pfam:PF07508. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	25.00	25.40	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-9.09	0.72	-4.16	35	694	2011-05-25 13:00:02	2011-05-25 14:00:02	1	13	232	0	54	600	82	68.50	34	13.31	CHANGED	pplsphcppptcs-+FlsllcKYsshpELTsshlsEhl-KIlVHcs-+..psu.pRpQcI-IYasalGplchPp	......................t.plsp.pppssssc+.Flpllc+YsshpELTsshlNEhI-KIlVHEt.....pc.....css..p+......pQcIEIYasFlGphp..............	0	36	50	52
+14130	PF14288	FKS1_dom1		1,3-beta-glucan synthase subunit FKS1, domain-1	Coggill P	pcc	Jackhmmer:	Family	The FKS1_dom1 domain is likely to be the 'Class I' region just N-terminal to the first set of transmembrane helices that is involved in 1,3-beta-glucan synthesis itself [1]. This family is found on proteins with family Glucan_synthase, Pfam:PF02364.	27.00	27.00	33.00	28.20	24.40	26.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.62	0.71	-4.18	84	502	2011-05-25 13:11:19	2011-05-25 14:11:19	1	19	190	0	335	501	5	109.40	43	6.37	CHANGED	pcplhplALYLLIWGEAsNlRFhPECLCaIF+...hAh-.......h.t.hps.......ht............tts-tsFLsplITPlYphl+spsh.......c............htpct..c.........HsphhsYDDlNphFW..tscsht+lths.p	.........................cclhpluLYLLlWGEAsplRFhPECLCaIF+.............hA.-....................hht..ts......h.p.............ss-tsaLspVITPlYphl+spshc.................................hctcpc......HsphhsYDDlNphFW.scsht+lsh...p.................................	0	90	208	296
+14131	PF14289	DUF4369		Domain of unknown function (DUF4369)	Eberhardt R	re3	Jackhmmer:A7UYJ0	Family	This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00578.	25.00	25.00	25.20	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.45	0.72	-4.02	232	931	2011-05-25 14:05:07	2011-05-25 15:05:07	1	13	192	0	223	886	222	108.30	20	31.00	CHANGED	hsl...su.s.....s.pp.....t.........s....aplpGplssh.......ss.....splYL..hth....ps...st...h....s.....lDSstl.p.s..G.pFsFp..s.p..h..s.p..s....phhhl...............hh.p....s............tpp.........hhs.......hhl-.sG.p.lp.lps...........st..t...p...........hp.l..sGo.tt....scphp	....................................h..hsuC...spt......t................p....aplpGplpsh.....cs..........splYLtth......ps...st....h......s................lD...ostlp..s..G..pFsFp...s.s..h...s.p...s....phhhl................ps..................tpp...................hhs.........hhl-.sG.p..lplph.............stt.p...........hpl..pGo...scth...............................................	0	117	201	223
+14132	PF14290	DUF4370		Domain of unknown function (DUF4370)	Coggill P	pcc	Jackhmmer:	Family	\N	25.00	25.00	169.20	169.00	20.40	19.40	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.50	0.70	-4.89	7	36	2011-05-25 14:53:12	2011-05-25 15:53:12	1	1	20	0	17	31	0	219.80	54	96.89	CHANGED	M.....c+.hhtlRslhRuAshtSup.uuh..tpttl..cpth.tpRohhsLsusu................ttlsu-hp..sshuhuhGspRhFSEDVoHhPsIpDPcl.sAFKDLMAASWsELPsullp-AKpAlSKNTDDKAGQEsLcNVFRAAEAsEEFGGlLhoL+MElDD.lGlSGENVKPLPs.htsAl+TsapRYssYL-SFGP-EsYLRKKVEhELGoKMIHLKMRCSGLGuEWGKVTlLGTSGLuGSYVEQRA	................................................h............hR..shtu.t...h...t..h....h....tshssLsps.....................thsu..t..us.uhShs.RRhFSos.pHLPsIpDP-lcsAFKDLhAsSWsELPDSlVp-AKKAlSKsTDDcAGpEALcNVFRAAEAsEEFuGl.LVoLRMtLDDLsGLoGENVtPLPsalccAl+ouYpRYhsYL-SFGP-EsYLRKKVEsELGoKMIHLKMRCSGlGuEWGKlollGTSGluGSYVE.RA....	0	2	10	14
+14133	PF14291	DUF4371		Domain of unknown function (DUF4371)	Coggill P	pcc	Jackhmmer:Q9C842	Family	\N	24.80	24.80	24.80	24.80	24.70	24.70	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.41	0.70	-4.82	19	987	2011-05-25 15:07:50	2011-05-25 16:07:50	1	37	67	0	777	904	0	167.60	21	32.17	CHANGED	-uFVspGapsa.p..c+pR..hcpHlGp.l.sSsHp.ApcKh-shhppppsIspshpppocptKtpYhsRLshSIcssRaLL+QGLsFRGHDESc-ShN+GNFlEllsalAcp.c-lp+llhpsuspsshhss.pIQ+plhpshApcspp.Ih--lGsshFulLsDESpDsspKEQhAlsLRYVDKpGp........VhERFlGlVHVp-TTSssLKsAI-uLLscasLSLpplRGQGYDGASNM+GchNG	................................................................................................................................................................................................................................................................................................................................................h....s......................................................................................h......th.h.t.hh...t..................h......h...h......................................................h...p......................p.......h.pp.l..phh.u...pt.l..h.p...lh...pp..l...p..s.....p....h...F...u.l.h.hDcstD.h.u.p.p.c.Qhsl...hlR.a.l....p.t.p.t............ltE.cF..l...shht.h...p...p...............t...............s....u..tl.hphl......p...h..l.t..p...h.sls...h......pp..hh..upsa..D...suush.s............................................	0	218	578	708
+14134	PF14292	SusE		SusE outer membrane protein	Eberhardt R	re3	Jackhmmer:A7V649	Family	This family includes the SusE outer membrane protein from Bacteroides thetaiotaomicron, Swiss:Q45769. This protein has a role in starch utilisation, but is not essential for growth on starch [1].	25.00	25.00	25.00	26.10	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.71	0.71	-4.29	45	304	2011-05-26 07:22:16	2011-05-26 08:22:16	1	4	133	0	53	283	22	120.30	19	29.15	CHANGED	lhhh.hhhhsuCpcDp..phtsh...psps....s.pLthsssssslsLst...us....s....A..lphsWssAshtss..s.slpYslphsttss.sFuss.lshs.psss...tpphohTspcLNs.l.h.s.p.h.Gl.tsspsssl..phclpu	...................hhshhhhsuCpc........Dt..p.ssh...p.ss.....shsLstss.s.s.spl.sLst...tss..s...u..lphsWop.s.....s......hsss.............s........s.....l..s...Y.........plp......hsh.....ts.t......sFsss..hths..pstt........ptphshottpLNp.h.h.s.......p.h....sh....tss......ptspl...hpl.........................................................	0	23	47	53
+14135	PF14293	YWFCY		YWFCY protein	Eberhardt R	re3	Jackhmmer:A7V7D7	Family	This family is found in bacteria, and is approximately 60 amino acids in length. There is a conserved YWFCY motif. It is often found in association with Pfam:PF02534.	25.00	25.00	28.40	27.40	24.00	23.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.62	0.72	-8.72	0.72	-4.13	13	298	2011-05-26 09:50:59	2011-05-26 10:50:59	1	4	115	0	29	252	8	59.80	61	10.31	CHANGED	QpEDDLRALAKIMDFhRAlSIlllllplYWaCYpuh+tWGlslsVlD+ILhNFpRTuGLFu	......QQEDDLRALAKlMDFhRAlSIlhlllNlYWFCYpuhctWGlslGVlD+ILhNFpRTuGLFp...	0	13	26	29
+14136	PF14294	DUF4372		Domain of unknown function (DUF4372)	Eberhardt R	re3	Jackhmmer:A7V8G9	Family	This domain family is found in bacteria, and is approximately 80 amino acids in length. The family is found in association with Pfam:PF01609.  There is a single completely conserved residue G that may be functionally important.	25.00	25.00	26.40	25.00	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.26	0.72	-4.10	46	284	2011-05-26 12:17:13	2011-05-26 13:17:13	1	3	143	0	79	290	118	72.30	32	23.51	CHANGED	ppupslFuQllchls+ppFccllc+.apG-ptl+pFosasQhlsMhauQLotp-SLRDIpssLpuppsKLYHLGhpp	...........psphlFuQllphlspppF.pphVc+..apuc+asKpFosasphlsMhauQLoppcSLR-lpssLpupp.t+haHLGht.t............	0	33	60	73
+14137	PF14295	PAN_4		PAN domain	Coggill P	pcc	Jackhmmer:Q2FN86	Domain	\N	27.00	7.00	27.00	7.00	26.90	6.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.70	0.72	-9.18	0.72	-4.25	64	1029	2012-10-02 11:41:37	2011-05-26 14:20:17	1	128	214	14	794	1625	53	47.50	22	13.28	CHANGED	sDh.GsDh.psh..h.......s.s.......s..psCtttCp.psspCp..uaoasp...............s........s....upCaLK	........................................ph.G.s..h..tt...h......ts.s........................s.spsCpphC........p....s........s.....s........s....Cp..hao.ass.........................t...........t......tp..CaLK...................................	0	389	539	755
+14138	PF14296	O-ag_pol_Wzy		O-antigen polysaccharide polymerase Wzy	Eberhardt R	re3	Jackhmmer:A7V9M7	Family	This family includes O-antigen polysaccharide polymerases [1]. These enzymes link O-units via a glycosidic linkage to form a long O-antigen [2]. These enzymes vary in specificity and sequence [2].	25.00	25.00	25.30	25.10	24.90	24.20	hmmbuild  -o /dev/null HMM SEED	447	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.71	0.70	-12.83	0.70	-5.90	29	375	2011-05-26 13:28:48	2011-05-26 14:28:48	1	3	336	0	31	222	10	415.20	39	91.97	CHANGED	ls.h.hha.llshhh......sshphlh...hslh..hlhlh.shlas.h.........pphphh.hhh...hFhhshFlFlhup.h.lshh.....h.s.h..........hshp.ahp.phhh..ps.....hhlhhluL...lhhalGhll...hppp..phph...pptptpp....pph...hpthphl..shhlha.lshl..th....lht.hpplhhhtssuYhuhYts..htpp......h.s......t.hhhhhu..shhhhu...hhlaL..sohss++c..hhh.hhlalhhtll..slltGpRs.hlhslLhlhhYahhpph............hlshhphhhlhlh.sshlhhh.........hshhshlRsp.............p..htt.shh.sslhcFhhsQ..........GlShtlluh.........shphp...splstpt..sYsh..hhph.h..t.l.tt.lhuh.hsh..tspshc.sh.ssshucplsY..hl.ssstYLtGhGhGoSal..AEhYhDaGhlG...lhlhshl...lGhl.l.....thhpp..hh..pps....hhh.hhh.shhhlsslhahPRushhs.l..hhhhhhhhhllhlh	.........................................................................................................hl...h.h.hhhhh..........sp...ll....slh....hl.l.ls..sllhs.h..........scl+hhhl.aa......lFhlolFlFL.lo.R..Ps.lsYF.........t.s..s...........ulc.s...Yps......shp....aA.....alllhlSl...LGlshGulL....hs++...+.lKh..tshusshc.....csa.....lKpL+hl....S.LslFl.Lsa...s..ah.......hlc.ap......cLla.p..lp.......so..Y.hAhYss...acSp................L.P.....a.FshhLS......saslhu....hshYL....uo+P..+K.hp......u.ptl.......L.ls..alssssl....pLslG.oRss.FILoILhsFlYY.ahRcp.........+........tKaIuhKcplsIalu.usILhl.u.........MGl..l.sYlR-ss.................p..loas.uhh..-lllDFlYcQ...............G.sSau...V...Lup.........uhhas....spLPhcc...NaTaGsll-a.Fspus.L.us.IFus..pu.h....hsssSl-lulcuNSaAHsLSY...ll.lsc.cY.L.pGa..GlG...SS.....Y...I..hE....lYs.DaG..hlG....VFL.lSF.L...LGlL.l.....uhLps.....sh.....+..s+....sIl...hsl...uL.llL..ssLF.F..hP..RuSFop.sahsLhshpFhslllllh........................................	0	12	22	27
+14139	PF14297	DUF4373		Domain of unknown function (DUF4373)	Eberhardt R	re3	Jackhmmer:A7V2U9	Family	This domain is found in bacteria, eukaryotes and viruses, and is approximately 90 amino acids in length.	25.00	25.00	25.70	25.50	23.40	24.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.77	0.72	-3.69	44	354	2011-05-26 15:13:09	2011-05-26 16:13:09	1	4	157	0	42	290	6	91.60	23	32.64	CHANGED	YFsh-sshhpDpplphlht+.h.G.hcGhuhhhhllpplhp.pssY..hsshpt...h.......ph.hApch..s..hst..........splcpllp......-a...sLF...s...hpp....p..t..hpS..t..lp	.........YFshssshhpDtclctlttc.a.G.hpGhulhhhlLsp.l.Yc.psta..hh.hcp....h........hhlupph...s..hst...................ctlppllp......ch...sLFs...hpp......p..t.lloSttl............................................	0	14	33	41
+14140	PF14298	DUF4374		Domain of unknown function (DUF4374)	Eberhardt R	re3	Jackhmmer:A7VA08	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 406 and 466 amino acids in length.	25.00	25.00	27.00	25.50	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.65	0.70	-5.90	8	125	2011-05-26 15:24:25	2011-05-26 16:24:25	1	2	81	0	32	115	0	283.90	23	80.97	CHANGED	oSCoDs-s..P.....usus..ssssKusYVIAuosssSsussshLLTAESLDEGolSolsNGL.ssDGuT.WVFYcspYLYuLsYNQGsAGTTpSYILsuNsclcpRstoYslpRFTTYGIYscaIlTsSTGDGspEhsDpNGYlPpuFLlSYLDVscpThTTNs.ppppshLuENFLGNGEaVTLAGIlEsNsKlYouAIPMGLSpYGsp..s-sGt..hlLssspDLVKTEsGGSGSGuYcKGEL.WTQYPNcsaVAIasssoFsscKlI.cTDKISYACGRhRSQYYQTIWuADNGDlYVFSPSYAKTM........oDt+QQT.TLPAGVVRIcAGuE-FDssYYsNLEppouG..+uFlRCWHIosDYFLLLMYD+.....s....lTt.TuhsAsELAlFKAEspKLTYV.oGLP..Ss.lISGFGNTPYsENGhAYhAV.TTT-G.pPAlYKIDPsoAoATKGloVE	.................................................................................................................t..........................................................................................................................................................................................................................................................................................s.asspsalAlas...........shp.p.ll.pss.+hu..hhsuh..h..h.hp.tlh.hs-sGD.lYlF.S.suhsth...........ts..t.o.phPuuhhRIptut......p-FD.sYahshpt.sss.....t.....hhphhalsts.h.Fll.hh.sp...s..........hst...ps.....hsspp.h..u.l..h..cs....t.stp.hh.l.pGlP...st......s...s...h.u..t...t...s..h...s.-..p..G...h...sYhsl..ssp...pG......s.h......lYplDstsupAs+Ghpl..........................................................................	0	10	31	32
+14141	PF14299	PP2		Phloem protein 2	Coggill P	pcc	Jackhmmer:Q9C8U9	Family	Phloem protein 2 (PP2) is one of the most abundant and enigmatic proteins in the phloem sap. PP2 is translocated in the assimilate stream where its lectin activity or RNA-binding properties can exert effects over long distances [1].	25.00	25.00	26.70	25.50	24.00	24.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.04	0.71	-4.83	88	511	2011-05-26 16:48:35	2011-05-26 17:48:35	1	14	50	0	261	487	0	150.10	27	61.38	CHANGED	Gt+CaMLSARs.LsIsWu-s...sp.YWpWhsh..............spSRFtEVAcLhsV.sWLEIpG+lssphLSPsTpYusYhlh+l.............s-p..saG......h-..h..Pl...............c.h.....slsh.....................................................s..ss.............................................p.p..p.....................p.p.php...........h..p..............................................cRs......DGWhEl.-lGEFh....s.s..p.....s.....pss....ElchSlhEsc...ssph..KsGLllcGIEIRPK	..........................................................t.shhlsu+.s.Ls.I..sh....hs...s....p..YWpahsh..............spu..ca........clA.L.pl..hW....l.-lpGplphph..h...ssspYsshhhhph.....................tcp...shG......hc..h....sh................p...hplsh...............................................................................s...st.................................................................p.p.........................t..tthph..p..............................................ptt......-.sWhEh.chG.-Fh....sp....p.........t.........pss.....clp.hsh..h-h.c...ssph..KsGLhlcGl.tIpP.........................................	0	40	141	190
+14142	PF14300	DUF4375		Domain of unknown function (DUF4375)	Eberhardt R	re3	Jackhmmer:A7VAK3	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 156 and 204 amino acids in length. There is a single completely conserved residue G that may be functionally important.	25.00	25.00	25.20	25.30	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.57	0.71	-4.13	41	346	2011-05-27 08:18:22	2011-05-27 09:18:22	1	4	298	2	55	291	11	119.00	25	63.69	CHANGED	-.shppLss-Q+sLlAhphLcpEVpsGGFsQhhtNuhGtalh.pshhcuh+paGhcchscllpcupplYtpp.t.sl-c-pp..tcph.shh.cp.....a..st.....F--hDcpah..-hEE..phsphlspYlcpHh-pF	.......................ht.Lsscp+pLhAhphhcu-VtsGGFsQhltN.uhG..th.l..h.pshs....cuL+phGspchspllc+At.s..l...a..pppttsl-pp.tp...tp......ch.shh..cp.........h..tp.....h-ph.Dctaa..-ht-...phhthl.stalptp.t.F...........................................	0	24	34	43
+14143	PF14301	DUF4376		Domain of unknown function (DUF4376)	Eberhardt R	re3	Jackhmmer:A7UZK5	Family	This domain family is found in bacteria and viruses, and is approximately 110 amino acids in length.	25.00	25.00	25.20	25.10	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.34	0.72	-3.94	46	601	2011-05-27 09:01:56	2011-05-27 10:01:56	1	7	328	0	48	539	8	107.00	30	60.69	CHANGED	L-ps+stKhsEIsshRsptpss..u..hshp..u.tchtsspps..p........hp...hssslt.....h.upps.shs.tsh.....hWpssssts..lshs.......hh..shttslhp..p...sp..phapcppph+pplpuhpshcslpuh	...................Lcts+pt+hp..EIpshRspppst.s..hsac.....s..tph.s..ssss...p............hp...l.sslh........h..Apss..sh...sth..............hW.sD.....uDNpp....V.p.loh....-hht....sh.spuhss..+...spcIap+pcphKpclps..hsshpplps.................	0	8	29	41
+14144	PF14302	DUF4377		Domain of unknown function (DUF4377)	Eberhardt R	re3	Jackhmmer:A7V378	Family	This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	25.00	25.00	25.40	25.20	23.30	17.50	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.49	0.72	-4.08	59	285	2011-05-27 09:46:05	2011-05-27 10:46:05	1	11	240	0	66	282	16	80.30	31	37.50	CHANGED	lhVsspp..ssC..s........Gh.....hshpChtV+pp...spp..........sWp.haYssIcGF..s..a-sGacYtL+V+c..hpltss.....PADuush.pYpLlcllpKp	.......................................Vuspp...ssC...s........Gh.....sshpCLpVRcs...tts..........sWp.haa..us..IEGF..s..acsGhcYhLcVpc..hphtNP.....PADu.uu.h.tasL.pllpp.........................	0	15	38	53
+14145	PF14303	NAM-associated		No apical meristem-associated C-terminal domain	Coggill P	pcc	Jackhmmer:Q9SKG8	Family	This domain is found in a number of different types of plant proteins including NAM-like proteins.	27.00	27.00	27.10	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.40	0.71	-3.90	48	509	2011-05-27 10:45:57	2011-05-27 11:45:57	1	15	25	0	377	488	0	144.70	18	46.12	CHANGED	+sFshhHCWplL.+spsKWpsch.p........................t.pp.ppt..........psssps....sssss...pts..sss....sp....ssstp........................................cRP.GpKpuKpthp..........................th.c..................................c.tp.........................cc+ht...p..p.......hppt....p......cc+h..........p.................hccc+h-hcphp....pEccIMhsDhosl.ss.pppa...hcthpccI	..................................................................................................Fph.asWplL.+ppsKWpsh.tp..........................pp.pt..........................tstspp...sstss......sts..sss......sp.......ss..ttt.......................................................................pRPhGpKtAK.pphppt........................h....th.............................................................t...........................ppcht..p......thtp.....p............ppph........p.................hppcp..hphp.h...........t..plh.hDhssh.s...................................................................................................................................	0	143	254	311
+14146	PF14304	CSTF_C		Transcription termination and cleavage factor C-terminal	Coggill P	pcc	Jackhmmer:Q8VYM7	Domain	The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.	23.00	23.00	23.00	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.65	0.72	-8.16	0.72	-4.68	4	329	2011-05-27 10:51:39	2011-05-27 11:51:39	1	13	212	1	210	290	1	43.80	49	10.15	CHANGED	spp.tupAtLl.QVhpLopspIshLPPtcRppIh.LRpQlp+ut.sp	.............cpsALlhQVLQLos-QIuhLPPEQRpsIlhL+pQltps...th.....	0	56	96	153
+14147	PF14305	ATPgrasp_TupA	Glycos_tran_Wfd;	TupA-like ATPgrasp	Eberhardt R, Iyer LM, Abhiman S, Burroughs AM, Aravind L	re3	Manual	Family	A member of the ATP-grasp fold predicted to be involved in the  biosynthesis of cell surface polysaccharides such as the O-antigen  in proteobacteria, the capsule in firmicutes and the polyglutamate chain of teichuronopeptide [1]. 	25.00	25.00	25.80	25.10	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.30	0.70	-11.53	0.70	-5.06	14	355	2012-10-10 13:17:03	2011-05-27 14:24:01	1	11	269	0	99	342	80	230.60	28	73.88	CHANGED	pKlQahKlh...scs.hhshhsDKhpl+calpcphGpp.hlIPhluVhsph...psIcapplP.ppaVlKssHsSG..shhlspscsphshhpsp.....pch.pphLpp....shhhhsREa.Ypplp.+lIlEchhtcpss........cDYKhaCFpGpsphl.lplcR..psppptshashsaphlsh...stpa......stpphpKPsshc-hlplu....cpLSpc..hPaVRlDhYpsssplYFGElTFh...suuGht.chhPc-aDchlGchhp	......................................pKl.ahh..h......ppshhsphsDKhtVRc....altpph.s....p....p....hllPhl.s.hhssh.....p-ls..a..spLP....ppFVlKssHsoG.......sshls...pDK.sph..s.hp.pht.....................pph.pphLpp.................sahh..hs+Eh.p.Y+slps.+.Il.sEchlt....sp.s.s.....................tD.Y.....KhasF...s...G.....c....s.....p..hl..l...sh.s.R.........tsp.p.p....h..s...ha.D....h.s.W.phhsh......p.phs.........stp..h.s..+..Pp.ph....cchlplA....cpLups......hs.a.V.RVDhY.t.s....ss........c.lYFGElTFt...ssuG..h....ph....hspp....hDhhhGphh...........................................................................................	0	37	55	77
+14148	PF14306	PUA_2		PUA-like domain	Bateman A	agb	Bateman A	Domain	This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes.	27.00	27.00	27.10	27.10	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.81	0.71	-4.83	89	1267	2012-10-02 17:37:24	2011-05-27 16:48:36	1	16	994	50	512	1155	428	155.00	30	31.10	CHANGED	ltPHG..G.....pLh........shllpsp.ptpphhpcutp...L.Pp..lplospph...........sDLphlutGsFSPLpGFMscpDYpuVl-ph+L.s.............s........Ghh...WolPIsLsVsp-ptpp..lptGscluLppt...Gph.lAllp.lp-hYph...-KppEAppVatTs-..t............HPGV.phlh...ppschhluGslpllpp	.....................................lhphhs.tt...phpt.hhtc..App.....h...p.lplsphpl....................................s-LpllupGhaSPLpGFMscc-Ypp...Vl.cph..+L..s.........................s...........................Gsl.......aolPIsL....s....ls....cc....ptpp...................lc....s....G...s....c.lsLhtp........Gph..lAllp.l.p-hap....cKpc...cstplauTss..t.............HPuVp......hlh...ptGchhlGGslpllp.....................................	0	175	312	427
+14149	PF14307	Glyco_tran_WbsX		Glycosyltransferase WbsX	Eberhardt R	re3	Jackhmmer:A7V083	Family	Members of this family are found in within O-antigen biosynthesis clusters in Gram negative bacteria, where they are predicted to function as glycosyltransferases [1,2].	26.10	26.10	27.00	26.40	24.70	26.00	hmmbuild  -o /dev/null HMM SEED	345	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.38	0.70	-5.28	84	380	2011-05-31 07:37:58	2011-05-31 08:37:58	1	33	282	0	99	359	61	323.30	31	59.13	CHANGED	+lIAaYLPQFHPl.P.E.NDcWWG+GFTEWTNVs+A+PhFcGHYQP+..lPs.-.LGaYDLR.s-shctQAcLA+caGIpGFCaYHYWF.sG......K+lLE+Ph.cp.lL.p.ssc.DhPFCLsWANEsW.o+.pWcG...t....spcl....LlpQpYssccD..ppHh....phll..hF+DpRYI+l-G.KPlahIY+P.......ppl.PchpphlphWcph.Ap.csGlsslahlsht.......................tth.tt......p......hphGaDussph....t..........stt......h.tth..................s....htt.......thtph...hppt............h....th....sph.h..........c.Ys..phhpphls.p..t.t.....p....h..phaPslhPsWDNosR..........+sp.p.uhl.hhsuoPctFcpaLppsl.p.p.sp.p.p.......pcchlFINAWNEWAEGsaLEPDh+aGhuYLcAl	......................................................................................................................................................................................hlAaYLPQaHsh...E....ND....tWWGcGFTEWsNlt.pAp..PhFpGHhQP+..hPh.p.hGaY..DLp.sc..shptQsclA+phGltGFsaaaYWF..sG...........+pl....LE.pPh...pp.hL.....p.st..c.D.hPFClsWANcsW.s+pWsu.............t.....ppcl...............LhtQpYs.st.pD.....htpah....phlh.thFpDpRY.l+l-.....G..+.Pl.hhlYcP..............ttl...schpphlphWc.ph.sp.c.tG.h.sslahhtht.................................sth.t.........p..........tphu....a....Dushph...tshh.h..ht................................h.t.......ph..hp.h.hppt...................h...........hph..h..........cYp..chhp...t.hhpp...p...t..........s.....hphaP.s.lhs..sW.DNo..sR..............ptt..p.uh....l.....h..hs.uoP.cta..ppalppt.hp.h.st..p.p........ppch..lFlsAWNEWuEGsaLEP.Dh.+.aGhuaLcsh.................................................................	0	40	76	89
+14150	PF14308	DnaJ-X		X-domain of DnaJ-containing	Coggill P	pcc	Jackhmmer:Q93ZH5	Domain	IN certain plant and yeast proteins, the DnaJ-1 proteins have a three-domain structure.  The x-domain lies between the N-terminal DnaJ and the C-terminal Z domains. The exact function is not known.	27.00	27.00	27.80	27.50	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.16	0.71	-5.05	53	402	2011-05-31 12:29:53	2011-05-31 13:29:53	1	12	193	0	305	409	4	194.00	27	43.07	CHANGED	ptpccRlpcLuppLhc+lp.as........c..ssp........cp.........Fpp+.hppEsc.sL+hESFGl-lLHsIGtlYppcAspaLtppp......pahG.lut...........haspl+.sKGcsh...Kssa.......sslsoAlcAppsh-p.hp+.......hpppt...................s.c..h....spcc.....hschpcp...htu.............K......hLsshWphs+aEIpssL+cVCpplLpDcsV..spcpRhpRAcALhhlGchFppsccs.s..c...-pppt.psFEc.lhs	........................................................................h..ppcR.ppLuppLhc+lp.as......................c..ssp..............cp............Fppp.hc.Es........c.pL.phpSFGh-.....lLcsIGhsYhppAsphL.ppp..........ta.hG.lst...........hhp.th+...s.Kuphh....+sph..........ssh.ssAlsh.phhcc.ht+.......h.pppt...............................................................................................t.p.......spcc............htchtcp.hts..........................................................................p......hLsuhWphshh-IpssL+cVCpplL.....p.D..p.sl.......s.p..cphhtRAcALhhlGplappstps..p...cttt..................................................	0	122	199	273
+14151	PF14309	DUF4378		Domain of unknown function (DUF4378)	Coggill P	pcc	Jackhmmer:Q9FIS0	Family	\N	25.70	25.70	26.00	26.20	25.10	25.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.02	0.71	-4.18	103	449	2011-05-31 13:05:52	2011-05-31 14:05:52	1	9	28	0	299	412	0	156.50	19	19.00	CHANGED	p-...hpYlp-lL.tsuGl.h.pst.t............h.....p..h..psssp..PlsPslFcpLEppt.........s..................................ttsptt+.scR+LLFDhlNEsL.......s.......chht........hshpshhp.....th......shphp.........h...su..pp.Llc-lhpplpphht.......ps....h.pp...p.....t........ll..scD.hspp.....tt....hh.....shpp......-sppluh-lEchlhc-LlcE	.............................................................hpYlpclL..sush.htp................h...........t.h..h.ssp..slssplFpplEpphs...................................t.tttpp.c++LLFDhlNEsL.............s..chht.........hshtshhp.......htht.h............h.....ss...pp...Llcclhp.plpphht...............ppt.....h.pp.....p.....t.........ll...tcD.htpt.........tt..hh.....shpt......-hpplsh-lEchlhc-Ll-E..................	0	50	182	249
+14152	PF14310	Fn3-like		Fibronectin type III-like domain	Eberhardt R	re3	Jackhmmer:A7VAA0	Family	This domain has a fibronectin type III-like structure [1]. It is often found in association with Pfam:PF00933 and Pfam:PF01915. Its function is unknown.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.23	0.72	-4.04	1123	4829	2011-05-31 13:39:53	2011-05-31 14:39:53	1	85	1882	11	1761	4491	425	70.70	32	9.16	CHANGED	EVVQ...LYl..p......s...s..s......u.........s......l..s..cP.s..+pL+GFpKl.p.Lps.GEoppVsh.s.ls.t....c.s....luhac.t.......p...t....p..........ahl-...s......Gp..aplhl..Gs..SS	...................EVVQ...lYl.p........s..s.s.........u...............................s......h....s..cP....s....+pL+GFcKlp..Lp........P....G........E.oppVsh.s.ls.h....c.s......L.uhast........p...t....p.................asl-...s..........Gp...aplhlGssS...........................................	0	582	1136	1550
+14153	PF14311	DUF4379		Domain of unknown function (DUF4379)	Eberhardt R	re3	Jackhmmer:Q7UL48	Family	This domain is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. It contains a CXXCXH motif and a CPXC motif.	24.50	24.50	24.70	24.50	24.40	24.20	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.21	0.72	-4.15	113	571	2011-06-01 07:26:03	2011-06-01 08:26:03	1	19	105	0	218	533	412	55.50	29	36.58	CHANGED	scLspEas.....csp.....hpPspVshuSph+shW+Ct..pC.uH.cWcAplssR.o.....spssGCPtC	...............................clhpEWs....tcNt........hsPpp..lsh.s.S..p...pcs..a..W.cCs.........ps.uH..pWpuplpsRs........tpspsCPhC.....................	0	153	193	213
+14154	PF14312	FG-GAP_2		FG-GAP repeat	Eberhardt R	re3	Jackhmmer:Q7UNP1	Family	\N	23.00	23.00	23.00	23.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.48	0.72	-3.95	180	1055	2012-10-05 17:30:43	2011-06-01 10:35:36	1	62	110	0	582	1179	1780	50.20	34	23.05	CHANGED	asppsKLsA.oDGuusDhF.G..hSVulsus..s.hlVGAh...t-Ds...ts......s.GuAY.lF	.................tthlhu..s....s.....s...s...s..sD...t....F.G....h.S...Vul..su-..........s..llVGA.................t--s................sus...............s.u..GusYlF.........................	0	432	550	571
+14155	PF14313	Soyouz_module		N-terminal region of Paramyxovirinae phosphoprotein (P)	Coggill P	pcc	Karlin D	Domain	The soyouz module moiety is the N-terminal region of the phosphoprotein (P) from the subfamily Paramyxovirinae of the family Paramyxoviridae viruses. The main genera in this subfamily include the Rubulaviruses, avulaviruses, respiroviruses, henipaviruses, and morbilliviruses, all of which are enveloped viruses with a non-segmented, negative, single-stranded RNA genome encapsidated by the nucleoprotein (N) within a helical nucleocapsid.	21.30	21.30	21.30	21.30	21.00	20.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.66	0.72	-4.41	16	410	2011-06-01 10:13:34	2011-06-01 11:13:34	1	9	40	3	0	415	0	56.90	54	14.64	CHANGED	MshhsDsEIscLl-pusslI-pIppupspssc..ThG+SsIstGsTcsLssAWEccsssp	...MATFTDAEI--LhETSGTVIDSIITAQGKssE..TVGRSAIPQGKTKALSsAWEKHGs.............	0	0	0	0
+14156	PF14314	Methyltrans_Mon		Virus-capping methyltransferase	Karlin D, Coggill P	pcc	Pfam-B_840	Family	This is the methyltransferase region of the Mononegavirales single-stranded RNA viral RNA polymerase enzymes. This region is involved in the mRNA-capping of the virion particles.	20.20	20.20	20.30	20.40	20.10	20.10	hmmbuild  -o /dev/null HMM SEED	675	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.07	0.70	-13.08	0.70	-6.68	10	144	2012-10-10 17:06:42	2011-06-01 13:38:09	1	2	69	0	0	167	31	660.80	50	31.64	CHANGED	l+.p-G-W-sLossEKSYHVGRslGFLYGDLshp+Ssps-DSSLFPLSIptKlcGRGFLRGLlDGllRuSulQllHRRolspLK+PtsAlaGulhYLI-KlossssFhsLlRcGPIR-ElpoIPHKIPoSYPToppDhGtllRsYLKpph+plccupYposhss.lWlFSDltSpc..alGshulSoplLchLhcssLSK+s+spLRcLusLppplRoscs..h..s-hclcplhpchL....hCspElRHAsKF..shsKpssspthh.......WG.pEhhGslpplPV.Yoossss....chhphs.PRlQNPLISGLRlsQlATGAHYKlRoILsshcIpacDsLssGDGSGGhTuslLRhNspSRuIFNSLL-lsGpsh+GopPsPPSAL.slGs-.psRCVNt-osWEcPSDLScppTWcYFhcLKpphuhpIDLIVhDMEVpD.phsppIEppl+calhpLL-csGsLIaKTYGThlsspsps.slshLGshFcoVpLlQTphSSShTSEVYllh++h+phl.DssalDasoL..pchhpplasFps.+pEFcRA+plpppchlhGlPsplIPDPhV-LpTlLpIuGVsSGluHplsp-lppupush.phAlllsslIsa.p.shslo+hhs.p..phpPPSDucll+hhsslsGlshWLSltppDlshapphppllscsh.sI+atptht+.uphhhpW	.................................................................................................IcL+sGDaEoLoscEKShHIGoAQGLLYSILVAhHDSGYNDuoIFPVNIYuKVSPRsYLRGLARGlLIGSSICFLTRMTNINIsRPLELISGVISYILLRLDNHPSLYlMLREPsLRuEIFSIPQKIPAAYPTTM+EGNRSlLCYLQ+VLR....YE....R-sl...os...SP-sDhLWIFSDFRSsKMTYLoLlTaQSHLLLQ+l.-+sLSKpMRspL...RQhuSLMRQVLGGHGE.sh....-SD--IppLL+DuLp+.........T+WV.DQEVRHAA+o..Mpuc.h.S..P..s.c.+.hSRK......hGsSEWlCSAQQlAVSTSu.NPAPhS-hDlRsLS....+RhQNPLISGLRVVQWATGAHYKLKPILc-LslaP.sLs.LVlGDGSGGISRAVLsMFPDu+LVFNSLLE...VsDLMASG.THPLPPSAIhoGG-DIhSRVIDa-SIWEKPSDLRN.sTW+YFpSVQcplNMoaDLIICDA.......E..V.......TDIu.Sl.N+.......IsLLhS.......DFuh..SI.-.GP.lhLlFKTYGThLlNs.-Y+.Alp.HLSRAFPoVsGalTQhTSSFSSElYL+FSKpGKFF.RDuEaLTuSTL...REMSLV.LFNCSSsKSEhpRARSLN.YQDLlRGFPcEIISNPYNEMIITLIDu-VESFLVHKhVDDLEL...p+GsLSKhuIIlsIhIlFSNcVFNloKsLs.-P.hFaPPSDPKlLRaFsIpsuThhaLSsshGDlssFs+LH-LYNpPl..oaYFc+Qsl+.GphalsW............................................	0	0	0	0
+14157	PF14315	DUF4380		Domain of unknown function (DUF4380)	Eberhardt R	re3	Jackhmmer:Q7UYS3	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 288 and 372 amino acids in length. There are two completely conserved residues (G and E) that may be functionally important.	26.50	26.50	26.90	27.00	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.73	0.70	-5.22	21	128	2011-06-01 12:55:25	2011-06-01 13:55:25	1	2	114	0	49	125	11	260.80	25	81.04	CHANGED	tua.pslpLuNsslclslTsslGsRIlta.uhpG.upNlL............s.htsthttsstschhhhuGpRlWhuPE.........t..+p.....a.PD....ssshphp......ppsltlpssssshoGlphphplplsssp.splplppshp......Ntstt.slphshWshThlss.uGhshhPlsstsph.........pl.hhshophtps.phphpcchlslpssstst......tKlGhsspsGWhAh.htpsplFlcpashhs.sA..pY.P-hGhshEh..Yss.......pshlEhEshuPhtpLpPGpshpapEpWpLhc	...................................................h.pslplssshlclhlssshGsRllpa..uhps..ttNhh...................tt.hh.ss..tsphhhhGGc.+lWh.....uPp...........................................cp......a.PD....s...tshphph......pssl..tlppssp......t.h..sslphphpl........p....h.pss.............p...spl..plptplp...................Nhssh.....sl.....p.....huhWslohls..........s..s.......uh..hlPhs..stss....................pl..hhshs.phts..Rhhhscphlhlctssp.ps.........hKlGhss..p..tG..W...hAh....hs..sspla..lcpath.....su..tY.P-h.........G.phEs..Yhs......................shhlEhEshuPhhpLpPGpphpa.E.WpLh.................................................................................	0	27	42	45
+14158	PF14316	DUF4381		Domain of unknown function (DUF4381)	Eberhardt R	re3	Jackhmmer:Q7ULH4	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 158 and 180 amino acids in length.	27.00	27.00	27.10	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-11.19	0.71	-4.09	111	458	2012-10-09 19:59:19	2011-06-01 14:55:13	1	4	391	0	131	402	66	145.10	27	87.80	CHANGED	sLtpLpDltlPsslu.aWP.A.GWWllhsl...llhhlh..hhhhh....hh.++ppp.p....t..h++t..ALptLsplpt..............sssphhsplspLLK+sAlshh...P+p..plA.sLsGpsWhpaLcspts..........hssthtp..tLhp....thYpstst...............hpp..lhptsppWlcpp	...............LtpLpslhlP.pssu..WaP.A.GWWlllsh...llhslh....hhhhh...........hhp+tpp....p.............t....h++p..ALptLsph.............................sssphhpplstLL+csAlsha....P+p...thA.sLs.GcsWhsFLDspss..............t..hsshtp.....hhhpshYpspsh............ps......hspLhptsppWlcp...............................................	0	28	57	95
+14159	PF14317	YcxB		YcxB-like protein	Eberhardt R	re3	Jackhmmer:Q7UN84	Family	The YcxB-like protein family includes the B. subtilis YcxB protein Swiss:Q08793, which is a functionally uncharacterised transmembrane protein.  This family of proteins is found in bacteria, and is approximately 60 amino acids in length.	24.30	24.30	24.30	24.30	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.41	0.72	-8.92	0.72	-4.72	258	600	2011-06-01 13:57:44	2011-06-01 14:57:44	1	4	461	0	124	522	35	62.50	16	34.41	CHANGED	l..sccslth.....ps....spspsph...pWsplpp.lhcscphhhl....hh.......spt.phhhl...P+.c.shs........ttph.....pphhphlp	........................hpppulhh......ps....tpspsph...tWspltc.lhcscphhhl....hh.........spt.pshll...PK.c..shs....ttph....pphhth......................	0	41	86	104
+14160	PF14318	Mononeg_mRNAcap		Mononegavirales mRNA-capping region V	Karlin D, Coggill P	pcc	[1]	Domain	This V domain of L RNA-polymerase carries a new motif, GxxTx(n)HR, that is essential for mRNA cap formation. Nonsegmented negative-sense (NNS) RNA viruses, Mononegavirales, cap their mRNA by an unconventional mechanism. Specifically, 5'-monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate between the large polymerase protein L and mRNA. The V region is essential for this process [1].	21.70	21.70	22.00	41.60	18.00	21.60	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.57	0.70	-5.34	63	729	2011-06-01 14:32:24	2011-06-01 15:32:24	1	9	223	0	2	766	0	237.80	32	11.27	CHANGED	sCSsslActLRphSW.....GRplhGlTsPcPlEhhss..hh.ttp.Ct...................Cp..t..sppp.....hohhh...hss...lspstp.spu.tsPYlGSpTpE+p...hhphhphcstsshlKpAl+ltsshpWhhssssp.hpphhplhpstssl...shsphphl.sh.poushtHRhssupsppthhsus.sthsoahphosDshphhsct....pshslhaQp...llshuhhpshhth.pssshpstshHhHhpsssCl+clpps	...........CSsplAchLRppSW....tGRpIlGlosPcslEhhcs.tllpsotsCsh........................Cp..s..Gspp.....hohhh...lPuthplsssspts.u.+lPYlGSpTpE+p...shphhphtsho.plKsAl+ltsshtW..saucs-.sphpthhplupu+ssl.....oh-.l+hl.Ph.pouNlhHRLcDutsphpassushsplusalplSsDshshhtp-..tsp-tNllaQp.hh.LhGLulhcohh.hppspshsp.hslHLHhchssCl+.h.............	0	2	2	2
+14161	PF14319	Zn_Tnp_IS91		Transposase zinc-binding domain	Eberhardt R	re3	Jackhmmer:Q7UXQ4	Family	This domain is likely to be a zinc-binding domain. It is found at the N-terminus of transposases belonging to the IS91 family.	25.00	25.00	25.00	25.30	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.33	0.72	-10.87	0.72	-4.56	72	995	2011-06-01 15:28:09	2011-06-01 16:28:09	1	9	449	0	150	849	144	105.20	32	30.65	CHANGED	t-Ihcp...ahssa...p...p.pa....sttls.spt+shpuIhpCRT.sshGsphhpCps..Csppc.hhhpSC+sR.aCPpCQspssppWlppppsclLP.ssYFHl.VFTlPtpLpslshp.spchlYs	........................h..lhpt...hhs.h........p.t.......tttltsh.hcshschhtCGo.thhGh.pphpC..ss...Cs+p+.hlshS.C+sR.tCPpCGs+tsspWlthhhscl..s.ssahHl.VFTlPpplhslhhpsp..h..h...........	0	56	94	121
+14162	PF14320	Paramyxo_PCT		Phosphoprotein P region PCT disordered	Karlin D, Coggill P	pcc	Jackhmmer:Q4VCP9	Domain	The N-terminal half of the phosphoprotein P of the Paramyxovirinae viruses.  The very first 60 residues have been built as the family Soyouz-module, Pfam:PF14313. The remaining part of the region, here, is disordered, and is liable to induced folding under the right physiological conditions. The region undergoes an unstructured-to-structured transition upon binding to Measles virus tail, C, unstructured region.	27.00	27.00	317.60	317.20	20.10	19.80	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-11.87	0.70	-5.53	3	49	2011-06-01 16:08:56	2011-06-01 17:08:56	1	3	3	0	0	53	0	296.20	78	57.10	CHANGED	ERRNLEDLSSTSPTDGTIGKRVSNTRDWAEGSDDIQLDPVVTDVVYHDHGGECTGYGFTSSPERGWSDHoSGANNGNVCLVSDAKVLSYAPEIAVSKEDRETDLVHLEDKLSoTGLNPTAVPFTPKNLSsPAKDSPVIAEHYYGLGVREQNVcPQTsRNVNLDSIKLYTSDDEEADQLEFEDEFAGSSSEVIVGISPEDEEPSSsGpKP.ESVG+sIEGQSlRDsLQl.KsNKssDsPGAGPKDSAVKEcs....PQKRLPMLAEEFECSGSEDPIIQELLKENSaINuQQGKDAQPPYapGIEuSpSPDKTEITuDA	EGRNVEDLSSVTSSDGTIGQRVSNTRAWAEDPDDIQLDPMVTDVVYHDHGGECTGHGPSSSPERGWSYHMSGTHDGNVRAVPDTKVLPNAPKTTVPEEVGEIDLIGLEDKFASAGLNPAAVPFVPKNQSTPTEEPPVIPEYYYGSGRRtDLSKSPPRGNVNLDSIKIYTSDDEDENQLEYEDEFAKSSSEVVIDTTPEDNDSI..NQE..EsVGDPSD.QGLEHPFPLGKFPEKEETPsVRRKDSLMQDSCcRtGVPKRLPMLSEEFECSGS-DPIIQELEREGSHPsGSL.+LREPPQpSGN.SRNQPDRQLKTGDA..	0	0	0	0
+14163	PF14321	DUF4382		Domain of unknown function (DUF4382)	Eberhardt R	re3	Jackhmmer:D2PI33	Family	This family is found in bacteria and archaea, and is typically between 142 and 161 amino acids in length.	25.00	25.00	25.20	25.00	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.90	0.71	-4.10	62	266	2011-06-02 07:47:30	2011-06-02 08:47:30	1	4	221	0	121	260	33	151.60	24	46.45	CHANGED	ssGs....lslslTDA...P..ss..sh.....ppVhlslsplplp...t....sss................sps.......shh...shs.......spp...lsl...........................thhsus.tp.....Ls.........ptslP.uG.p.YsplRLhl.s................s.........ss.......................ls.h...s...G....sphs.LpsPSut...ps.sl.Kl....s......s..hslp..uss.sshslDFDsppSl.......s.tG.ss..pYhLKP	.......................suslsltloDA...P..ss..sh..............spVhlslsplplps....sss......................................................sss........shh..sls............spp...lDLh..........................thtsus.tph.....lu....ptslP.sG.p.YpplcLhls................s..sp..............................lsh..s..G.....sphsLpsPSst.................ps..tl.cl.....p................shslp.sss.sshllDF-hp+ul.......s.pG..ss....pahL+P...........................	0	39	73	106
+14164	PF14322	SusD-like_3		Starch-binding associating with outer membrane	Coggill P	pcc	JCSG:Target390309 Jackhmmer:Q8A1B4	Family	SusD is a secreted starch-binding protein with an N-terminal lipid tail that allows it to associate with the outer membrane.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	190	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-11.65	0.71	-4.24	44	6539	2012-10-11 20:01:04	2011-06-02 11:11:39	1	8	205	26	1561	6470	663	202.60	17	36.62	CHANGED	caLDhp.Ppup....h..sps......h.chps.....hls.....sh.h...ssh.s......hht...thh....thsp.hh..ss...hsss.h...s.t...tsh...h.t......ht..h.........pphsh....s.....s......sss..s......shWsshYp.sI...hssNhlLcp.........s...pp........p.hs....t.....lh.GEAhhhRAataahLssha.............u............t..l..Ph.s............p....sss...........s.............p...............t..s....h........s..Rs..Tlp-lYppIhsDLppAhsl.Lspst...............ph..+hsh..puA.hAhhARhYL	......................................................................................................................................tt.................phpt........hht...............sh.h........tth...t...........................t....h..................t.......hh..........sp.............hhs.s............t.....t.......t.s.h..t.t................h.......................tp..h..ss.......s.........s.............sth....p...........................sh..W......p......t.......h...Y......p......s.......I..........ppsNh...h...lppls.........tth.s...pp..........................p.tp...p........hh..uEAh.......hlRAahY.a.pLlpha.........................G...............s...l..P.l..h...................s......psp....................s...................s....................h....p......h..........s.....R.s....o..h.p.-....l..h...s.h....I...h.p...D.L...p.....p.......A..h......s......h......L..s..tptst.................................hs...R...hsp...suA.hulhu+hhL................................................................	0	739	1439	1561
+14165	PF14323	GxGYxYP		GxGYxY sequence motif in domain of unknown function	Coggill P	pcc	JCSG:Target393069	Family	This family carries a characteristic sequence motif, GxGYxYP, but is of unknown function. Associated families are sugar-processing domains.	27.00	27.00	64.20	29.60	23.30	22.90	hmmbuild  -o /dev/null HMM SEED	464	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.69	0.70	-5.78	18	103	2011-06-02 10:20:36	2011-06-02 11:20:36	1	8	61	1	42	97	11	377.40	22	66.51	CHANGED	hlsoLQGlVNp.opspIY.l..psp.s.....s.pphhcphppp..hG.lsasc..lss..sasLLs+a+p..tlcGhVlYDsp...pssSlNlAsolAGlcsulslspsLhsplpstGlpt..l.t.DlRs..hs.......tp.......ahYsp.YhsphsHphlltLs..Pc...ph.stLRDYAl...h....op.uhlFhDssss...-..........psLhcphhusMss.u.uhshGWa......s.D.Et.sVphuSpaGluhluuDashNLoVhSuhsp.osshp....ptsshst.....hpNKhYVoFlhSDGDNlQas....ashpphassPs..RGplPlGWolSPuhh-luPslLsaYYcoA...osN..DsFIuGPSGsGY..hYPsph.............sp.s.p.LssahphspsYMp+ssh+llsIhD....ssshs.stsl.hsp.........astp.ssl.ulah.sasppss.......Gplhh..NstPslupcshhh.tlps..ph....pslpspIspuhsshss.sPtFhhl.lcsWsp.sh.sslpslhspLs....pN....lcVVsPDpFhpLh+c	......................................................................................................................................................hsolpGllsp..pp........pla.h....t............p.t.hhtth.pp.....ht.lt.hp....hps....tllphapp....hpGhllasst......ohs.Asol.Aulpsulsh...s.t..h.th.lp.thsh.....h...Dh+s..hs...................ht.......ahhpp.h.sthspphl.h.hs..sp......h..h.lp-ash....hsp..hh.a.h.pss.......p...........hslhpplh..st..h....t....s..u....hhGW.............s.c....Eh..lphsSp.h.G..h.h.lsuDa....Nhohhosh.....p...h................p..t..........pshhYlsahhSDGDNhQa.......ht..p..hasss...RGph......shsW.olu.P.slh..hsPslhphahpsu........s.N...D.hlsusSGsGY..hYPsth.............sp.s.t.httahphhppahpphs.phh..lh.s.......t.t.......t.th....hpt...hh....th.uhhh.tht...........h.h.h......sth....sh.t.p................................tth.t.ltth.t..tt....a..l.h.sWt.......pth..hht.ht..........h..h....h.............................................................................................................................	0	34	40	41
+14166	PF14324	PINIT		PINIT domain	Bateman A	agb	Jackhmmer:	Domain	The PINIT domain is a protein domain that is found in PIAS proteins [2]. The PINIT domain is about 180 amino acids in length.	27.00	27.00	28.00	30.60	24.60	26.80	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.77	0.71	-4.11	38	474	2011-06-02 13:21:12	2011-06-02 14:21:12	1	9	214	1	256	469	0	149.60	39	24.75	CHANGED	shtsslpFKcsPFYclh.chlpsos.h.ts.....................sp..p+ppsp..hpFpLsspphpplpst..........p...shplhLhst...........sh........hssss.spphpFP..slpl+lNsp.lphshpu.psKsGs.....sRPsslTs..al+hs...sh.Nplplsass.....ssc.............pYhlhlhLVc	..................................+P-lphppLPFYcllspLl.+P....osLssss............................................sp...+h.p-sp..hhFsLTP.p.Q.lppIpssh-.........t.h-hslQV.LR............................hCh........s-TSs.sQEDpFP..sslplKVNsc.ss.lP........sh.hPssKsGsE................KRPsRPlNITs.........hl+LS..ssssN..pIsloWus.....hs+...............sYshulYLV+.............	0	53	96	175
+14167	PF14325	DUF4383		Domain of unknown function (DUF4383)	Eberhardt R	re3	Jackhmmer:C1CUZ6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 137 and 164 amino acids in length.	27.00	27.00	27.10	27.20	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.72	0.71	-4.11	66	192	2011-06-02 14:11:15	2011-06-02 15:11:15	1	1	132	0	100	202	10	124.70	29	79.76	CHANGED	sphsAhshGslalllGllGFl..PGlss..st......................hsstputuhLhGlFtlshLHNllHLlhGlsGLh..hups.ssuARhahhshGhlYhsLhlhGlhhs.......tp.oh..........sshlPl...............NsADsWLHlslulshlslGhhh	...............................phsAhllGslaLllGllGFl...Puhss...........................hsttstuhLhGlFs..lshLHNllHLlhGlsGls..huts..tssARsahhssGslYhllhlaGlhss.......ts..sh................sshlsl.................NsADsaLHlshulshlslGhh.h.......	0	32	69	93
+14168	PF14326	DUF4384		Domain of unknown function (DUF4384)	Eberhardt R	re3	Jackhmmer:C1CXC5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 80 amino acids in length.	27.00	27.00	27.00	27.00	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.51	0.72	-4.15	69	228	2011-06-02 15:09:03	2011-06-02 16:09:03	1	22	137	0	127	233	36	83.10	23	20.24	CHANGED	ssYphG.-plphtlps.....scsuYlhlhsl..sssG.plshlhPNthpts.........NhlpuupshshP........sstas.....hplssPhGp...pplhslsoppsl	.............................aphG.-plpltlps.......spsu.Y.lhlhsl....ss.sG..pl.shlhPNthpts.........shlpuspsh.plP..........sstap........hpls.sPh..Gp....-plhslsopp......................	0	39	84	118
+14169	PF14327	CSTF2_hinge		Hinge domain of cleavage stimulation factor subunit 2	Coggill P	pcc	Jackhmmer:Q8VYM7	Family	The hinge domain of cleavage stimulation factor subunit 2 proteins, CSTF2, is necessary for binding to the subunit CstF-77 within the polyadenylation complex and subsequent nuclear localisation. This suggests that nuclear import of a pre-formed CSTF complex is an essential step in polyadenylation. Accurate and efficient polyadenylation is essential for transcriptional termination, nuclear export, translation, and stability of eukaryotic mRNAs. CSTF2 is an important regulatory subunit of the polyadenylation complex.	27.00	27.00	27.40	27.20	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.37	0.72	-3.90	52	428	2011-06-02 16:18:23	2011-06-02 17:18:23	1	16	266	3	292	397	2	82.30	36	19.13	CHANGED	..lPsshs...sshpss-sIopsLuslsPsQLh-llsphKp.LsppsP...spAcplLtpsPQLuh.AlhQAhllMshl-spllppslpp	..............................................h.sshs.s..ss.sus-.sIopsluoLPP.pQhh-lhpQMKh...hspssP....pcA+phLhpNPQLAY.ALhQA.llMplVD.sphhhphlp.t...........	0	85	153	229
+14170	PF14328	DUF4385		Domain of unknown function (DUF4385)	Eberhardt R	re3	Jackhmmer:C1CYW3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 149 and 163 amino acids in length.	27.00	27.00	32.30	32.20	26.30	26.30	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.87	0.71	-4.27	28	238	2011-06-03 07:02:05	2011-06-03 08:02:05	1	1	235	0	57	138	307	138.60	63	93.28	CHANGED	FDYshDatpIDa..RppPEhYRVGRGEQGVLLVEPYKSEILPaWRFKTP-lAcpSS-KIYphFhsYhcpsDFlGMDMARKFLQMGaTRARRY.ANaKGG+KY..p..............sptcl.cpptD...scKAcuApIF+ppWcps+scppYhchKccapc...cY	.............FsYp.DFssIDF..RppPELYpVGRGEQGVLLVEPYKSEILPaWRaKstssAhcSAEpIYQLFEsYRpQDDFVGMDMARKFIQMGYTRARRY.AN...YKGGKKY.s...........................--GpLsscssD.......PlKAAAAslFKuhWD.+lRpDEDYL++K+pHQt+a.............	0	18	30	46
+14171	PF14329	DUF4386		Domain of unknown function (DUF4386)	Eberhardt R	re3	Jackhmmer:C1D3W7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 214 and 245 amino acids in length.	24.80	24.80	24.80	24.90	24.50	24.20	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.58	0.70	-4.86	69	193	2011-06-03 07:11:31	2011-06-03 08:11:31	1	2	136	0	112	204	60	194.10	19	88.70	CHANGED	+huGhlaLlhhlh.....ulh.uhhhhtshl.........sssshssltsptshhphuhhhthlhslhslslAlhLahll.+..thspslAhsssshRll.tsslhslullshhsslhlh.ssssh..s.t.............th.shshhhhshashs..a.luh.lhh.....GlphllluhLhhRSthlP+hluhhhlluuhhhlhsshhphhhss.....thhshhhhlshhlsEluhslWLll+Gh	..................................................hsGhhhlhhhlh......uhh.u.h.hh.shl.........ssthht.thhspt..s.hh.hhuh.h.h..hlhslh.lshulhLa.ll.+...ths.......shuhhhs.hhtll.tus.lhshul.lthhshh.lh.pt.....................th.thshh.hht.htshs......hhlu....lhh.....Glthllluhlhh+ot....hl.........P+hluhlshluuhhhlhss..hhthhhst..........ht..hhhlshhlhElshslWLlhhG...........................	0	62	87	107
+14172	PF14330	DUF4387		Domain of unknown function (DUF4387)	Eberhardt R	re3	Jackhmmer:B5YEU8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are approximately 110 amino acids in length. There is a conserved RSKN sequence motif.	27.00	27.00	37.00	36.90	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.03	0.72	-3.67	38	189	2011-06-03 08:26:29	2011-06-03 09:26:29	1	5	181	0	59	130	55	98.20	54	62.14	CHANGED	Lt-lAcsIRSKNAGPa.lThDIhFcspcsY-plKposslspchlucLYtlss-cl.phh.a-sApAlKholsR.....shs.uGuhG-pDlaGuQQauPLLslpl	....ssLApVIRSKNAGPYELslDIlFKo+EsY-RVKsSutLTsElIAcLYclcP-hIhcIVaFDPusAlKIshPR.....slh.SGslGDsDVYGAQQHAPLLshp.h.....	0	19	37	50
+14173	PF14331	ImcF-related_N		ImcF-related N-terminal domain	Eberhardt R	re3	Jackhmmer:Q7UL74	Family	This domain is found in bacterial ImcF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the ImcF-related domain, Pfam:PF06761.	25.00	25.00	26.10	25.20	23.90	24.60	hmmbuild  -o /dev/null HMM SEED	266	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.54	0.70	-5.49	110	1314	2011-06-03 08:45:58	2011-06-03 09:45:58	1	12	877	0	250	1135	43	257.20	27	22.64	CHANGED	sssptDpstWpuFLsLL++pR.sRpPlNGlllslu.lscLlsss.stp...ptpApslRtRLpELpppLuhchPVYlllTKsDLlsGFs-aFssLspp.pRp.QlWGhT.h....shs...p..sss..sst..........hpp-astL.hpRLsspl.s+LppE..p...Dhp....cRstlasFPpQhuuLpshLtpalpplFtsspapps....shLRGlYFTSusQpG..s..s.h..s..p..ht..sh........s.p.......ph.......s....hs....ts.......s..s...s......s.....t...t............ss...s+.oaFlccLhpcVlFsEusLsu.ssh+hpt.....t.R...hh.t.ht.st.h...ssh.ss	........................t...t.ptt.WtthLshL++pR....s+pP.l.NGlllslsls-L.lssstpt..t...pphupsLRpRLpElpppLthphPVYlllTKhDLLsGFspaFpsLs..pp.pRs...plhGhT.hshp..t..ppsssh..................tthspp..ap.pL.hp+lsttlss.thttp..h....ssp.......pRstlasFPppht.u.LppsLtphlptlht.sst...apts....shLRGlYFT.........SuhQpG....ts.....s...h..sp...sh...............sp.......pa.............ths..tt..............s.....t....t.................................ss..sps..aFh+pLhspllhsEs.s...Lss..sh.p.hth....pt.R.hh.h.hh.hhh.....hh..................................................................................................	0	47	109	179
+14174	PF14332	DUF4388		Domain of unknown function (DUF4388)	Eberhardt R	re3	Jackhmmer:B5YCM3	Family	This domain family is found in bacteria, and is typically between 102 and 135 amino acids in length.	25.00	25.00	25.10	25.20	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.31	0.72	-4.18	165	493	2011-06-03 11:45:10	2011-06-03 12:45:10	1	42	129	0	296	484	46	131.50	20	34.04	CHANGED	pG.sLp...sh.sLs-llQhlptsp+oGsLpl.....pt.st............................lah..ccGpllp..Apt.s.............................................................thpupcAlhpl.l....thpp....GpFp.................ht.tthstttslph.sh..ppllh-uh+ph...DEhpth	....................tG.sLpph.sls-llphlptsp+oGh.Lpl..pttstp..up...............................lahppG..pl..ltApts............................................................................phps.pcslhpl..h.......shpp..Gp.Fp.............ht.ss.ttttplph...sh....ptllh-uh+hh..-ch..h...................................................................................	0	125	211	281
+14175	PF14333	DUF4389		Domain of unknown function (DUF4389)	Eberhardt R	re3	Jackhmmer:Q0EYR1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 104 and 223 amino acids in length. There is a single completely conserved residue R that may be functionally important.	25.00	25.00	25.20	25.10	24.00	24.80	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.18	0.72	-9.65	0.72	-4.27	51	266	2011-06-06 07:50:20	2011-06-06 08:50:20	1	2	225	0	91	250	268	80.10	31	48.89	CHANGED	hpppshahRllaMllhslhhpluphllhllsllQalhhLls.GpsNppLtsFussLupahhchhpahoaso-c+PaPF.....scaP	.................h.....hh+hlhhl.a.....hlVhhhhphshsslsllthhhhLho.GchspsLhsFssul.pahh+l..u..tYs..s..h..t..oDchP.PFs.............	0	38	59	83
+14176	PF14334	DUF4390		Domain of unknown function (DUF4390)	Eberhardt R	re3	Jackhmmer:Q0F0K5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 192 and 203 amino acids in length.	27.00	27.00	29.00	28.30	24.00	23.80	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.70	0.71	-5.06	70	309	2011-06-06 07:59:00	2011-06-06 08:59:00	1	1	306	0	114	259	83	164.20	31	82.02	CHANGED	utAsshplpp.hplp.tsc....sslh.LsuslphpLsttlc-ALpcGlsLhFsh-hpltRsRhaWh...Dcplsp.....tshph+LuYpsLT+paclstss............hspsasoLs-ALpslt.clpshtlhstu.........plpssp.sYplplRhcLDhspLP+PhQlssh.spssWslsos.hhp..aph	..........................tApslplpcsphp..sss....ushp..lsuc..hch-Ls..spLc-Alp+GlPLhFshchpLs+sRh.....aaa...-cplsp.....sshsh+LSapPLT.ccYRVosuu............hphsasoLcsALpslt.cls..sW+V.hsps.........plpsup..s.apuplRhpLDsupLP+.PFQlsAl.sspsWpLsSs.Wpph....h...................	0	35	76	95
+14177	PF14335	DUF4391		Domain of unknown function (DUF4391)	Eberhardt R	re3	Jackhmmer:Q0F339	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 220 and 257 amino acids in length.	29.90	29.90	30.10	30.20	28.70	29.80	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.06	0.70	-4.95	57	203	2011-06-06 08:05:32	2011-06-06 09:05:32	1	2	194	0	61	189	15	216.40	22	92.12	CHANGED	lslPpsst....ls+p........lPKpthh..cpsshssppKchhs-sl..-pIhahhplsspoh.sls....sspphpEItlhplpL+s..t....phspclh...cllp+tlPh.llh.lhp.....h.sschthshsaK...Rhsps-tschsl.pphhtosW............thhpslshs.h..thshtslYpshlpplhthps..............t.ht...........shtpphpthcphpclpcclspLcschp+E+Qhs++s-lNtcl+clcpcl	...............hslPpsst....ls+p........lPKphhh.....pps..shosp.Kphhhppl..-pIphhhtLpsssh.sls....sspph.El.llplpLps....p...............phs.pclh...clIppt...l...hsllh.hlp.......................h.ssphphshuh+...Rhttscts+hsl.tphatosW........................................................th.sp..lphp.h..sh......sltslYpslhpplhhhssph...................t.....................slstphtphpplppLppclscLcpchp.+-+phs++sElptcl+chcppl............................	0	25	44	55
+14178	PF14336	DUF4392		Domain of unknown function (DUF4392)	Eberhardt R	re3	Jackhmmer:Q0EY62	Family	This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.	27.00	27.00	27.80	37.10	25.30	24.90	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.69	0.70	-5.61	49	194	2011-06-06 08:24:43	2011-06-06 09:24:43	1	6	147	0	85	191	48	279.00	31	62.43	CHANGED	pl-pll..ssDhstcG...ltthh......ssu.hhpAup.......hL..................ppsppllIsTGFsl.....ssssETDGPsGAhsLupALpt.lGtcshlls-p.stpslpshhpshsh..ps..h...............................................tt.hpphp.shlluIERPGpusDG.pYasM+Ghslsth..ssshD....tlhhpupp...slsoluIGDGG.NElGMGsl.pptl.phlshusp..........hhusspsDpLllAsVSNWGuauLsAtLshhts.................................hl.shcpctp..hLctllptG.ulDGlotps.sho..VDGlsh.phptpllctLpph	............................................lpphh..shD.Gt.+G...ltplh..........t.st...lh.c.AuhtL.........................spsppVlls....TGFPs...........ttsstETDGPsGAlu......luthLpt.lGtcsslls......Dpp..shshhpthhpsts...psh.th.hs...........................................ttps..pp..p.hctlluIERsGpAsDG.pYaNhRuhsI.pph..ssslDpLFhtApp.......GlsohGlGDGG.NElGMGpl..cptlpphl.pGs...............IAsslpuDhhllAu..............VSNWGuYALsssLhhLts................................phl.s.hppc.ct..hLphllptG.shsGhott..shp..VDGlsh.phatphlptLh..h............................	0	28	37	58
+14179	PF14337	DUF4393		Domain of unknown function (DUF4393)	Eberhardt R	re3	Jackhmmer:Q0F0Z8	Family	This family of proteins is found in bacteria, archaea and viruses.  Proteins in this family are typically between 254 and 285 amino acids in length.	25.00	25.00	25.20	25.80	24.90	23.80	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.25	0.71	-4.85	48	194	2011-06-06 08:50:57	2011-06-06 09:50:57	1	3	178	0	46	155	1	182.20	21	69.96	CHANGED	c+lpplsp...cs..ltpss..splssssl-supat.ss-pLpchaupLlAsuhspspsppsHPuFscIlcpLossEAplLphlt................tsthshhshthhh..............pstshphhhsshhhhspp............s.pphss.lsNLpRLGLlphs...........h.h.ppthhpthcstphhpphttpht................................................thlplTshGppFhpssh	............................th......pt....h.ps....plhhssl-sspa....hspcpLpphaApLl.usuh-pp.pss.sH.uFlcIlcpLoss-AplLphlt.............................................ppp.hPhsphthhh................pststth.hhpsh.hhspt...................pphsh.lsNLhRLGLlphs.............hspps.hphh.t.s..thhpph.pth......................................................t.lploshGptFhpsC......................................................................................	0	11	32	40
+14180	PF14338	Mrr_N		Mrr N-terminal domain	Eberhardt R	re3	Jackhmmer:B5YBC5	Family	This domain is found at the N-terminus of the Mrr restriction endonuclease catalytic domain, Pfam:PF04471 [1,2]. Fold recognition analysis predicts that it is a diverged member of the winged helix variant of helix turn helix proteins. It may play a role in DNA sequence recognition [2].	24.00	24.00	24.20	24.20	23.80	23.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.91	0.72	-3.90	132	557	2011-06-07 07:50:11	2011-06-07 08:50:11	1	9	518	0	145	476	56	89.00	25	28.56	CHANGED	sapp............hh....hPlLchl..p-.Gt...ptphp-lhctlscphpLo-c...ctpphhs...oupph.hapsRluWApoaL.......p+AGLl.cs...sp.RG..haplTcp.......GpplLtpss	..................hpphhhPlLchL...ts.sp...ststc-lhc.tl.sct..h..s..ls-c.....pts.ph.hs....SGpp..hhpsRlsWApshL.......ppAGll..pp...sp...RG..haplTpt.......Gpphltt..........................	0	60	101	124
+14181	PF14339	DUF4394		Domain of unknown function (DUF4394)	Eberhardt R	re3	Jackhmmer:C1D3Q3	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 262 and 476 amino acids in length.	22.50	22.50	22.70	22.80	22.40	22.20	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.62	0.70	-11.58	0.70	-5.08	47	116	2011-06-07 10:49:46	2011-06-07 11:49:46	1	11	90	0	47	134	22	221.50	32	63.35	CHANGED	sphLh.hsssssspstpshploG.h.ssppLlGIDaR.........PssGpLYul....usp.upl..YoIsssoGt....uohl..........uthssslsus...shulDFNPsADRLRllos...sGpNLRlssD.......sGs......hshsD.........ssLshsssshp.u..............ssslsAuAYTNshsssp.s......TsLasIDsstst..LlhQs.........sPNsGsLsslGsL...Gl..ch.ssssGFDIs....sstt......ssssuassh....u..t.s..pLYpl-.........LtTGpuo.......thus..........lss..t...ltslAl	..................s..hl..h.sspssthhpshtloG.h.s.sppllGIDaR.........PssGpLYul.......sss...uplYolsssoGs.........AThl..............uthssslsus...shulDFNPss...D.....RlRllus...sGpNLRlss-.........sGs.........hs.sD...........GsLshs.ss.t.u.............t..ssslsAuAYTNshsssp.s.......TsLasIDsshs..tLhhQs.........sPNsGsLsslGsL.....Gl.....sh...ssssGFDIt..........s.ts..s.sttAatsh....s..s..s..pLYpls.........L..t.....T.GtAo.....thup.................lss.......ltslAl.................................	0	22	37	43
+14182	PF14340	DUF4395		Domain of unknown function (DUF4395)	Eberhardt R	re3	Jackhmmer:C1CVW5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 142 and 168 amino acids in length. There are two completely conserved C residues that may be functionally important.	24.00	24.00	24.50	24.00	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.66	0.71	-4.08	65	233	2011-06-07 11:45:19	2011-06-07 12:45:19	1	8	221	0	115	246	199	131.10	30	78.15	CHANGED	lD.pusRhsAslsslllllsLlsu........shh........lLsl.slsFslsshhGs+huPau....hlh..tplltPpL...ssschEsssPhRFAQhlGhlFussu.hlu.ahh.....GhssluhlssuhslsAAhLsAuhGhCLGC.lYhhlp+h	....................................................................ls.pusRhsAhlsslllhlsllss...................thh........llsh.slsFsls.shhG.s+hsPau.....hlh..t...plltsclt..sssc..h..EsssPhRFAQhlGhlFsssuhlu..ahh......................Gh.shl..uhlssuhslsAAhLsushGaCLGC.lYhhlt+.h........	0	40	87	105
+14183	PF14341	PilX_N		PilX N-terminal	Eberhardt R	re3	Jackhmmer:C1CZZ9	Family	This domain is found at the N-terminus of the PilX prepilin-like proteins which are involved in type 4 fimbrial biogenesis [1].	24.50	24.50	24.50	24.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.70	0.72	-8.35	0.72	-4.30	69	454	2011-06-07 12:24:02	2011-06-07 13:24:02	1	4	373	0	154	436	62	50.80	32	22.54	CHANGED	pGhu.Lll...uL......llLll.lollulushps...shhpp+huuNppppppA....a.uAEuulp	.....pGhs.Lll...sL......llLll.lolluluuhps...sshpp+huuN.pcpphA.....hpsAEuuLp..............	0	45	102	134
+14184	PF14342	DUF4396		Domain of unknown function (DUF4396)	Eberhardt R	re3	Jackhmmer:C1D417	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 167 and 310 amino acids in length.	27.00	27.00	32.00	31.90	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.77	0.71	-4.07	54	240	2011-06-07 12:30:05	2011-06-07 13:30:05	1	4	225	0	106	237	1104	138.70	29	53.90	CHANGED	shWppustuTlHCLsGCulG-lhuhhlsps................huhshhsth.sluhshuhhhGhhlphhslh..hpshshtpAl+tAlts-hlSlsshElu.ssshhhl...............uhshshssshFWhs.htluhhsGFlsshPhNhWhlp+GtKc	.............................WppsshuTlHClsGCslG-lhuhhhhph................huhshhsph.slshshAhhhGhhlphhslh..hpsluhtpAl+pAhts-hlSlsshplu..sshhhl...............uhshshssshFWhs.htluhhsGFlsshPhNhahlc+GhKc............	0	27	58	87
+14185	PF14343	PrcB_C		PrcB C-terminal	Eberhardt R	re3	Jackhmmer:C1CVC9	Family	This domain is found at the C-terminus of Treponema denticola PrcB, Swiss:B8YNY4. PrcB interacts with the PrtP protease (dentilisin) and is required for the stability of the protease complex [1].	24.00	24.00	24.30	24.00	23.90	23.10	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.72	0.72	-4.26	96	234	2011-06-07 13:08:52	2011-06-07 14:08:52	1	11	210	0	92	220	20	60.10	26	27.35	CHANGED	phall.lshGp+sTuGYulpl..pph.t.s...pssl...hlpsplhsPstsphssps.....h........TaPa...hllclpt	...................hlh.hshGppsTuGYulpl....ppl...ths......pssl.hlp...schhsPp..ssphssps.....l........TaPahllph..t...........	0	50	74	87
+14186	PF14344	DUF4397		Domain of unknown function (DUF4397)	Eberhardt R	re3	Jackhmmer:C1D258	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 120 amino acids in length.	26.00	26.00	26.30	26.00	25.80	25.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.58	0.71	-3.79	91	801	2011-06-07 13:44:06	2011-06-07 14:44:06	1	13	358	0	263	753	167	108.00	22	64.45	CHANGED	sutlRVhH.....uuPs.......uPsVDVal..ssph.........hlsslsapshos.YlslssGs.aplpl..hssGss.s.sss.lhsssl.sltssppYTlsAssshs.....s..hph........hshsDsh...p....t.hssspu.plplhHsuPs..A.PsVDlhl	............................................s.lRhhH.....hsss.......sPsVDl.h.l...sGpt............lhpsls.ap....p....h....o......s..Ylsls.sGs.aslpl....sss..uss.............s..l..h......s.ssl.sltssptYTlhAl.spss...........s....hph...........................hhh.c.....................................................................................................	0	85	185	241
+14187	PF14345	GDYXXLXY		GDYXXLXY protein	Eberhardt R	re3	Jackhmmer:C1CYU2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 171 and 199 amino acids in length.  It contains a conserved GDYXXLXY motif.	27.00	27.00	28.70	30.30	25.70	18.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.91	0.71	-4.34	106	394	2011-06-07 14:04:33	2011-06-07 15:04:33	1	4	391	0	107	331	16	153.40	27	55.03	CHANGED	lplshlshhlhpppthltpGcslhLclsPVDPRsLhpGDYhsLsY..slup.....................................tthtps...spsalhL..p..-spul...........sphhphpps...........s.tssplhlps.php...................................t.pl.....phu..h.-saahsEGpupphcp.sph.................uph+Vssp.GpulLhsLh	..............tlshlshtlhpppthLppGpslhLpltPVDPRsLhpGDYhsLsY..slss.s......................................t.p.tts........ppsalhlc...Dspsl...................................sshsphspst..........shsssphhlps.cht............................shpl..phu........h-pYahsEGpucphpp.u+h.................................................uth+Vssp.GpslLhsLh...............................	0	30	60	86
+14188	PF14346	DUF4398		Domain of unknown function (DUF4398)	Eberhardt R	re3	Jackhmmer:Q0F2G1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 127 and 269 amino acids in length.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.85	0.72	-3.97	51	449	2011-06-09 10:03:32	2011-06-09 11:03:32	1	13	287	0	153	393	38	104.80	24	52.41	CHANGED	hsshhluG..C...Au........sshs.spphptucpAlppApss..sAsp..hs.s......cLptAppcLtpA.ctshsppchp........pAcphAppApsc...AclApspupstpsppthpchpps..lppLcp	..................................................hhhhuG.C..us.............tshs.spphstAppulppAcps...susp.....A.sh........phcpAp-pLspA...ctu....h.p.c...t.pYp........cA.+plAppAptc...AclApp+u.sspspptlpphppt..hppl................................	0	42	68	114
+14189	PF14347	DUF4399		Domain of unknown function (DUF4399)	Eberhardt R	re3	Jackhmmer:Q0EYV0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 135 and 1079 amino acids in length.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.07	0.72	-3.96	72	404	2011-06-09 12:43:37	2011-06-09 13:43:37	1	27	222	0	152	401	417	86.80	32	24.73	CHANGED	VpFGLcG.hslsPAGp.tpss.....TGHHHLLlDsst.........shspslPts............tptlHF.....GsG...QTEs...slp.LsPGcHTLpL.hGDttHhsa........ssslhScpI	.........................................hGlps.hslsssup..hpss.....TGHHHLLlDsps.........sh.spslshs.............stlHa.....GpGpT-splp.L........sPGcHTLpL.h.uDt.Hhsh........t....o........................	0	22	100	127
+14190	PF14348	DUF4400		Domain of unknown function (DUF4400)	Eberhardt R	re3	Jackhmmer:Q0F326	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 209 and 249 amino acids in length. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	30.40	29.80	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-11.20	0.71	-4.93	58	389	2011-06-09 13:00:12	2011-06-09 14:00:12	1	2	295	0	93	325	19	189.70	27	84.40	CHANGED	huhhahhs-puhp+upphhppphshLusphs.cullhp..........psu..h......hh.......haphhFVc.oGhhshhpp...................s.tt.ttshphhsshhhphhpsalhushhsshhhhlRLs.lLhhslPlFlhsslsullDGLspR-lR+auuGhESualYH+A++hlh.shshs.hhlYLuhPh.ul.Phllhl...PsAlllGlslslssusFK	.................................................................................hhh.s-ts...hpp.pt.hphphshLusp.hspslhhp...................pss.....................haphhhVc...oGhhphhpp..........................ttttp.t.s.pshp..h.sshhhshhpsal.AhhhshhhhhlRls.lLhhhlPlhlhhhhsulhDGLspRclR+auuGhESualYHpApthlh.shhhls.hhlYLshPh..ul.Phllhl.....PsAhLlGlulshssusFK........	0	13	43	74
+14191	PF14349	SprA_N		Motility related/secretion protein	Eberhardt R	re3	Jackhmmer:B2KAY0	Family	This domain is found repeated three times in the N-terminal half of the gliding motility-related SprA proteins. The role of this domain in motility is uncertain [1]. It is also found in proteins required for secretion [2].	27.00	27.00	54.90	27.30	22.80	24.20	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.77	0.70	-5.23	88	445	2011-06-09 13:24:56	2011-06-09 14:24:56	1	3	146	0	160	475	719	425.90	19	52.43	CHANGED	tahshts.hh.h.tt..............hhs-P.............Yph.ahtp.......pl......................hp+Yh..................h...p.ttpshsssEc....pcsshsphpp..ah...pa+lsh...pssp......hhhG.ps..........hhlc.ps.splshss.......pahphc.P.........................olphhphahosFshshhlphushshVtuchp...sYsp...sh.s.s..sp.h..pht..............................pph-lusVslppNssh.........l..h..ssh.ptps.ss....sstlphscpsLohhlsp...........psucu+sV.....hpsps..lshcpYcchchF..............................tlGpsapsNY.p.pls.......s.....tpshshst...plW..hsNp...........s...t..sshc..h...................................ttphslhu.sslG..csh..tlpN.s..........................hsthsp.....sssslssshu-hsssshsuph...thhs.ppssp..ctppshpphsh......sth...s.phshphshh.utpp.........p..s.pasPhhsslpLpstLs	..........................................................................................hs....hhhh.tthst...........hhhss-s.............att.ahtp...................pl.........................hp+Yh.....................................ht.p..tp..shssscp.....psphschth.hspachsh....s.tp............h.hGst..........hpl.s.pGssplshGs..........ph...c.P...................................slp.tpcahssa......shsphlp..hs..uhlsuphphphsYps...sssa.shpsp..hhhshp...........................................................p.phspphplGslshp.spph............h....h..ssh.ttpstsolaGhssphpts.cptLohhlsp...........tsspspsl..phshpsp.h.lpstpYcp.pha................................hhupsah-sapp...sh...............t.....posl.slsp...plW..lsNp........s........ss.hp................................................tppRslluh.slu.....psh......h.t............................h...........ss....ssl.ssshu.shts.hp.hstph...thhs..p.p...tsp..ptppshpshsh...................t.phshh.st+t...t..papassths.h.Lp.......................................................................................................	0	73	145	160
+14192	PF14350	Beta_protein		Beta protein	Eberhardt R	re3	Jackhmmer:B2KEQ4	Family	This family includes the beta protein from Bacteriophage T4, Swiss:P13057. Beta protein prevents the gop protein, Swiss:P13058, from killing the bacterial host cell [1].	27.00	27.00	27.30	27.20	25.70	21.10	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.24	0.70	-5.26	43	134	2011-06-09 13:40:16	2011-06-09 14:40:16	1	1	129	0	34	119	2	313.80	20	94.46	CHANGED	YhPlL..+h+puEhpALpp.L..ssps+sp.lhPllplsthststpp.................pptspcltpshspt..shhsssp.......................pphhpsssthhs..hhhphhpptstp............llPVlshspss.....ph.psltpth......ttttlslRlptsphts.....phtptlspllstls.htss.phtlllDhtshp.sts.sthtthhsth......lpplsph..tapslslsuoSaPps.......hsshst.....ppstl.RtEhplapplts.......sttshaGDYusspspht......sstsspsss+lcY....ot.csp.ahlhR.stthpt.tht.......phh.sluppll...spst..a...ussaSWG.DphIpps.Aps..........ss.......GssopWhplssspHlshhlcp.l	......................YhPhL..+h+.puEhpALp.....pL...s.phtst.hhPlhpl....hs.p.................................pphhppltp.hstt...hh..sh........................tthhpsspt.ht......hhp.hpthsh.................llPVlthspss.....phhptltphh........tttlslRlp.t.th.s..........t...lspllsphs..h..s..ph.lllDhtslp.stst...th.tphhtth......lsplsp....hpplh.lsusuaPss.......hsshst.....t.tpl.RhEhplapplhp........hpshauDYushpsph.......s.thhp..ssplcY.....oh.csp.ahhhR..tthpptsht............phh.phsppll...sssp..ap..s.sp...asWG.DphItps.ups.........tss..............GssspWhplshspHlshhlcp................................	0	7	23	31
+14193	PF14351	DUF4401		Domain of unknown function (DUF4401)	Eberhardt R	re3	Jackhmmer:B2KEA1	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 357 and 735 amino acids in length. The family is found in association with Pfam:PF09925.  There is a single completely conserved residue K that may be functionally important.	25.00	25.00	25.20	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.54	0.70	-5.44	44	202	2011-06-09 14:25:50	2011-06-09 15:25:50	1	7	199	0	48	196	9	311.50	20	56.27	CHANGED	sWalplh................huhuuWlAulh..hLsFlhhshhhh.c......hshllhGllhhuhAhhlh....+tp.............thFhcQhulAhsluGphhlsaGlhphh.......thhshhlhhhhlhslhhhlh.s...hlhphL.shhhshshhhhhtthhh..........h.lshhhlshhhshl......hhth.........ttstththhpslshuhhlshlshhhhhsht.hhhh.................................th..hhhhhhhhlshshshhhlhhphph.l..ssshthslhhslslluhh.h..hsulshulllllluhhtspphlhululhsllhhluhYYYsLploLLtKShhLhusGllLLshthllh+hh	..................................................hhlphh................huhuualAulh..hLhahhhhh.hh.p......sshlllullhlshAhhlh................+t..............shhhpphulshhluGp..lhhhaslhp.h...................hhhhlh....hhhlhslhhhlh.s.....hhhphL.shhhshshh.hhhshhhh.................h.lh.hhhhshhshl.......hh.hh............tthhtttlp.sltauhhlshlshhhhthh.hhhhh..............................hh....th.thhhhhhhhhshhhhhhhhhhh...h.h.hh....ptth...th.....hhhh.slhlhs..hhhh..hsulshslhllLluhhtspphlhululhshhhhluha.YYpLthoLLhKShhLhssGllLLshthllt+..h................................	0	11	24	39
+14194	PF14352	DUF4402		Domain of unknown function (DUF4402)	Eberhardt R	re3	Jackhmmer:B2KBI6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 155 and 182 amino acids in length.	25.20	25.20	26.00	25.60	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.87	0.71	-3.68	65	129	2011-06-10 07:19:46	2011-06-10 08:19:46	1	2	54	0	66	133	13	131.50	20	75.21	CHANGED	lslsps..ss........LsFG........hhsssssGoVsl..sssG....shshsGssshhsssss.....sApFslsG.psspshslols.........sshslss........sssshslsshs.................sshstssthsssG..............stshslGGoL.......sls.usps..sGsYo.Go..asVoVsY	..............................................................plsps..ts........LsFG........hhss.ssssslsl.....sssu.....hs..sssh..hsssss..............sApFslsG.ps...spslslols...............sshslss..........ussshslsshs.................................sthsssshhsssG...................stslplGGoL..........sls..usps......sGsY.o.Go..hslsVsY......................	0	21	42	59
+14195	PF14353	CpXC		CpXC protein	Eberhardt R	re3	Jackhmmer:B2KC69	Family	This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea, and is typically between 122 and 134 amino acids in length. It contains four conserved cysteines forming two CpXC motifs.	24.00	24.00	24.00	24.80	23.90	21.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.84	0.71	-4.18	43	128	2011-06-10 07:51:50	2011-06-10 08:51:50	1	3	105	0	30	113	9	122.00	21	47.72	CHANGED	plsCPpCtpphchclhstlssspcsch+cpll.sGplhphpCPpCGpphhl..shshlYpD.p.c.chhl...hhhPc......tphppthphhtshph.........t.tttthphRllhshsplhEKlhIh-sGl-....D+hlElhK	.......................lsCPpCtpthphphh.shlssspcPchppplh.ssphhthpCPpCGpph.t.l..shshlYhD.p..c.chhl...hhsPp...........p.ttpphphhtthp...................htthphRhshshtplhEKlhlhcsuhscchhEhhK......................................................	0	18	30	30
+14196	PF14354	Lar_restr_allev		Restriction alleviation protein Lar	Eberhardt R	re3	Jackhmmer:B2KDC9	Family	This family includes the restriction alleviation protein Lar encoded by the Rac prophage of Escherichia coli, Swiss:P33229. This protein modulates the activity of the Escherichia coli restriction and modification system [1].	28.60	28.60	28.60	28.70	28.50	28.50	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.92	0.72	-3.67	63	206	2011-06-10 08:38:13	2011-06-10 09:38:13	1	6	176	0	44	148	11	60.10	35	47.56	CHANGED	tcLcP......CPFC.Gssslthps.......ppt.t.............................hhlt..........Ctp......C....Gu.................tsshtpscpp....AlctWNpRs	...............cLKs......CPFC.Gssplhlcs.......s.shs.....................................hhsc...Cst.......C....tu....................csshsssttt........AhcpWN+R.........	0	10	24	35
+14197	PF14355	Abi_C		Abortive infection C-terminus	Eberhardt R	re3	Jackhmmer:B2KEQ6	Family	This domain is found at the C-terminus of the Lactococcus lactis abortive infection protein Abi-859, Swiss:Q48620. This protein confers bacteriophage resistance [1].	24.00	24.00	24.40	24.50	22.10	19.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.67	0.72	-4.04	92	373	2011-06-10 09:57:38	2011-06-10 10:57:38	1	2	341	0	82	267	10	78.90	23	29.98	CHANGED	lspLh..phspptLshtsspttp..........t.hppll...sultsll........pulsslRN.ctu.suHG.....ts....pthtlsspcAcLslssusolst.allcs	....................................................h..pLh..ptshphlthp.ppp.t..........p.l+pll....puhssll....sulsplRN.ctu..suHG.....pst.....pthtl.s.pcc.AcLslssusolstalhc....	0	18	51	68
+14198	PF14356	DUF4403		Domain of unknown function (DUF4403)	Eberhardt R	re3	Jackhmmer:Q8KCF8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 455 and 518 amino acids in length. There is a single completely conserved residue W that may be functionally important.	27.00	27.00	46.10	46.00	24.40	22.90	hmmbuild  -o /dev/null HMM SEED	427	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.13	0.70	-6.18	41	97	2011-06-10 10:29:55	2011-06-10 11:29:55	1	1	88	0	59	107	9	419.20	20	89.72	CHANGED	stshSslslPlpls..lsslpphlNpplstphhspssh.ts....................ptplphplsRtGslslsus....ssplhhohPlpsphphthuhtshh.th.......................shstssphssslshsspsslsssWclssphp.....shshhppsslslu.sh+lslpshlcshlcpthpclpstl-pplppshsL+pplpphWpphpcPl.lsp......s.ssWLclpPpclhss...phsspslphslGlpupspsssus.pPt.....hPLPshphhs..shssphclslssplsas-lsphlspph...ts+sFs...sssh.plplcslplhu.ssc+Lhlsl...pspus.........hcGslalsG+PsaDssspplplpDl-aslcocu.h.Lhpsushlhpstlpctlppph...shslpsplspsppplpptlup..psspslclsuplpslphsclhhsscslplhlpAsGpsslplp	...............................................s..t.ShlslPlpls..lsslpphhsptlstphhtcss..ss....................ttplphpl..h.R.Gslslsss....ssplhhshPLphphphthuhtshh...........................hstssphpsslphsspspls.sWplpsphp.....shshhpssslplu.Ghclslss.lcshlcpthsphtstlspplpcshsL+ppspphWp.phpcPl.lsp........shWLplpPpclhss...phss.sslphslGlpspschssus.pPt.....hslPs.hhths....shssthplslssplsas-lscllppph...tu+sFs...........ssshplplcplslhu..sss+Lllslplpup............hpuslalhGpPhhDstspplplpDlchslcocs.h.Lhpsushlhpstlpptltpph...shslpstlspspppltptlsp..pstpGlplsuplpslplsclthsssslplhspApGplplpl........	0	21	40	52
+14199	PF14357	DUF4404		Domain of unknown function (DUF4404)	Eberhardt R	re3	Jackhmmer:Q8KFC4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 90 amino acids in length. There are two completely conserved residues (P and G) that may be functionally important.	27.00	27.00	27.00	27.90	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.83	0.72	-3.57	40	107	2011-06-10 10:45:52	2011-06-10 11:45:52	1	1	105	0	38	91	6	83.50	38	92.69	CHANGED	cLpppLppL+ppLp...psss.lD-sppstLpsLtc-IpphLpp...tsssttpcpsls-plsp.Alp+FEscHPpLutslcplhsoLusMGl	...........pLpcpLssLRcpL-...psss.ls.Epp+tpLcpLhppIEtplp........tstt..p-soLsDslNh.AlERFEspHPsluuTLRsIlpoLusMGI.	0	9	17	30
+14200	PF14358	DUF4405		Domain of unknown function (DUF4405)	Eberhardt R	re3	Jackhmmer:Q0F3T2	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria and archaea, and is approximately 50 amino acids in length. There are two conserved histidines that may be functionally important. This family is N-terminally truncated compared to other members of the clan.	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-9.14	0.72	-3.84	112	320	2012-10-03 10:28:09	2011-06-10 13:45:22	1	10	262	0	150	342	33	63.50	23	31.21	CHANGED	lphhlshhlhlshlhlhloGlll.hts.shh........hhuhstthhc.plHhhsuhhhhlhhslHl.hlpW	...........phhlshhlhlshlhhhlSGlll.hhs.shh......................hhshs.phhp.pl.HhhsuhhhhlhhslHl.shpW.....	0	53	92	121
+14201	PF14359	DUF4406		Domain of unknown function (DUF4406)	Eberhardt R	re3	Jackhmmer:B2KDC7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 98 and 145 amino acids in length.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-10.10	0.72	-3.91	41	334	2012-10-02 19:28:18	2011-06-10 13:54:17	1	3	282	0	34	299	91	89.40	37	77.64	CHANGED	lYIAGPMo..Ghs........-hN+ssFppsAccL+tpG...ahVlNPAph......Pssh.......s......acpYM+lslshLh.sCD..sIhhLsGWppScGAphEhtlAcpLGhplhht	..........................................................hYluGsMo....Gh...........saN+..AFp.p.stptL......+....p..cG....asV..l..NPAhh.............s-uh.......s...........scYM.c.hshshLp..ssD..sI.Y.h..L..p..GWppStGAptElslAc+LGhsVhh.t...........	0	12	23	30
+14202	PF14360	PAP2_C		PAP2 superfamily C-terminal	Coggill P	pcc	Jackhmmer:Q56Y01	Domain	This family is closely related to the C-terminal a region of PAP2.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.79	0.72	-3.71	54	511	2012-10-02 00:53:37	2011-06-10 14:41:37	1	8	174	0	334	550	26	72.40	38	19.26	CHANGED	tCGDllaSGHThhhslshhhhhcY....ssphh........h+hlhhllshhshhhIlhu+tHYTlDVllu..halsshla.hhYHt	....................hCGDhhFSGHTlhlslhhhhlpcY.............ss+ph.........................h+hls.Wllshh...u.hhhIlsu+..cHYolDVllAaYlostlF.hhYH................	0	123	175	264
+14203	PF14361	RsbRD_N		RsbT co-antagonist protein rsbRD N-terminal domain	Eberhardt R	re3	Jackhmmer:Q8KAB8	Family	This domain is found at the N-terminus of a number of anti-sigma-factor antagonist proteins including B. subtilis RsbRD, Swiss:P54504. These proteins are negative regulators of the general stress transcription factor sigma(B) [1]. It is found in association with Pfam:PF01740.	23.00	23.00	24.10	24.10	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.06	0.72	-3.58	74	220	2011-06-10 14:14:43	2011-06-10 15:14:43	1	6	201	0	98	227	5	103.70	21	39.90	CHANGED	slt..clLpc...ccpplLppWhpph.tphstcssth.ptc.hpp.ssslhpsltpulpsh.......hDhhssph......pplpphLssls+hRAhQGFoPscsssalasLKpslhchlppp	.........t.h.phLppccptllppWhcth.tp....hs....hp..sst.h..c.pc.hcppspslhpslspulpps..........hchtsssh.........splcphLsp...lu....+sRAhpGFoPscssshlhuLKpslhphltt............................	0	39	65	88
+14204	PF14362	DUF4407		Domain of unknown function (DUF4407)	Eberhardt R	re3	Jackhmmer:Q8KC28	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.	28.30	28.30	28.90	29.00	27.60	28.20	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.66	0.70	-5.46	54	204	2011-06-10 14:37:50	2011-06-10 15:37:50	1	6	166	0	93	182	38	296.40	23	61.13	CHANGED	s.slLcp.sss-psKasulGAslhhTAlhAsluuuaAlhhshsss.............hhulhhG.llWGlhIhsLDRaIVsohp+pst...............hhpphh.uhPRlllAlllulVIScPLpL+IF-pEIsppltptppppttphhsplss...........................thssphsthpsplsslppphsptpsplsthhpthpsEhpGs............ssoshhGhG.shhcp+ppphcstt.......splpslpsp...ssthsthc......................pphsphptsppthhsppp.t....sstsGlhsRhpALscLs.....tts..hhhsphhlhLLF.lulEhhPllsKLhsstus...YDhtlppp-pt	.............................................t..........t-cspasshGshlhhsuhhA.slsuuhA.l.tts....hpss.........................hhul.hu.llhGLhlhsl-Rhlso....u.t+tps.....................................h....h..t..sss..RhhlAlhlu..hVluc.ltLhlFp..spIs...pclpcp.t.pptpst.stlps..................................................ssplpphpsth...ssLcsplpptcsclspth..shhpsEhpss.................ptoGhsGtG.P.scptpphh.sstp...........................................tcLsshhsp...hspptstlc...............................................pptptltpsppt..hhst..............sstpGhhsRh.AhscLs......ts..s..hhhsphhhhhhh...hhlthhPllh+Lhpstss...aDhthttpt..p........................................................	0	31	59	77
+14205	PF14363	AAA_assoc		Domain associated at C-terminal with AAA	Coggill P	pcc	Jackhmmer:Q9M0V8	Family	This domain is found in association with the AAA family, Pfam:PF00004.	22.10	22.10	22.10	22.50	21.50	21.80	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.34	0.72	-3.94	102	409	2011-06-10 15:51:54	2011-06-10 16:51:54	1	12	26	0	238	417	0	98.40	24	20.91	CHANGED	hlP...t.p....lcp.....h.....l....t...shhtph.........hs....th.hss.hh.slsIpEhs.....u...........hp....pN............c.............hapAscsYLusph..ssp.....s....c+L+sspsc...pspt...................hslolcc.s-clsDsFc.GlclhWphsspp	..........................hP..plpth.....l....h.....phhtph.........ht....h...hs.shh.plslpEhs.....u...........hp.ps............c.................hapAspsYLu.s.p.s..ssp.......s....c+L+..sstsc.p.sps...................lslshcc..s-clsDsF.....p.....Gspl.hWphh...p...............................	0	25	137	200
+14206	PF14364	DUF4408		Domain of unknown function (DUF4408)	Coggill P	pcc	manual	Family	This domain is found at the N-terminus of member of the DUF761 family Pfam:PF05553. Many members are plant proteins.	21.50	21.50	21.50	21.50	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.39	0.72	-7.57	0.72	-4.39	37	166	2011-06-10 15:57:58	2011-06-10 16:57:58	1	2	20	0	93	164	0	36.80	33	13.20	CHANGED	hPplaushtua.............lsPshL.FlllNll...IhsIsupS+h	.....................................hhsshtsa.......................hoPshL.FlllNlI...IlsIssoS+h..	1	11	54	74
+14207	PF14365	DUF4409		Domain of unknown function (DUF4409)	Coggill P	pcc	Jackhmmer:O64569	Family	\N	23.90	23.90	23.90	24.10	23.50	23.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.73	0.71	-3.92	35	420	2011-06-10 16:12:37	2011-06-10 17:12:37	1	21	28	0	255	418	0	104.60	32	27.44	CHANGED	oIpSPD.GDlIDCV.hp+QPAFDHPhLK....s..hp....hcPs.p.pPcuhh.tc........p....p...........ppps.....spshsQlW+psG.c.CP-GTlPIRRTpc-...DlLRA..sSlp+aG+Kpppsh..sts.p..t..ss..hspsGHcHAluYs	.....................lpo.D.GDllDCVshpcQPAFDH..P.hLK..........s...hp......hcPs.....hPpsht.tp........................................ttt......tp.hhphWp.pss...p.CPcGTlPIRRs.pcc.......DllRs....p....S....ht....phsh..+..t.................................................................................................	0	51	132	159
+14208	PF14366	DUF4410		Domain of unknown function (DUF4410)	Eberhardt R	re3	Jackhmmer:Q8KCX4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 187 and 238 amino acids in length.	26.00	26.00	26.00	26.10	21.60	25.60	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.53	0.71	-4.43	38	82	2011-06-13 11:52:46	2011-06-13 12:52:46	1	1	73	0	41	82	7	130.50	18	64.47	CHANGED	lhVtsF...thpstth....t...........................ttstpppppstphscphusplspc.Lppp..ulhutpsssss....tsslllcGshtphctGspttRhhlG.hGA...Gpoplpsslplhs..................soG+hsuth.ssssssuuu	..................................................................................t...........................ptttp.ppphtt.hcphtpplhppLppp...slhsttsssss.....tshhlpsplpshchGssttRshlG.hGA...Gpsplsuslplh-..................sss+..sthpsssshuhuu...................	0	8	17	33
+14209	PF14367	DUF4411		Domain of unknown function (DUF4411)	Eberhardt R	re3	Jackhmmer:Q8KAB2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 153 and 170 amino acids in length. There is a single completely conserved residue D that may be functionally important.	23.50	23.50	23.70	23.50	23.40	23.30	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.13	0.71	-4.53	58	237	2012-10-03 20:43:45	2011-06-13 13:14:28	1	1	225	0	61	213	14	150.70	26	96.66	CHANGED	Yl.LDoNlhI..putppaYs.h-lsPuFWchLpphhp..sGplhohcpVt-Elpps.....sD-Ls.pWscppts...hhpss-...tshpphtplhpa....psspaptss....ttah.......shADsaLlAtAhs.pst.....slVTpEt......tsstpp............phKI.PslC..pthsVphhshaphl.+chshpF	............................................................Yl.hDosshl...........puhpphYt...shhsuhWphltphhp..ssplh..shctVtcEltpt.............sDchp..cWhctpts..........hhhs...t-........tph.pthtclhph....sppthppt...................ptADsalIAhAhs..pst...........slVTpEpt..........sss.pp............th+I.PslC..pth.s..V...hlshhphl.cp.shp............................................	0	23	39	52
+14210	PF14368	LTP_2		Probable lipid transfer	Coggill P	pcc	Jackhmmer:O49645	Family	The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.36	0.72	-11.38	0.72	-3.85	72	1249	2012-10-01 19:46:35	2011-06-13 13:37:29	1	18	64	3	722	1872	6	97.10	20	61.47	CHANGED	hlA..h..hhsssts...s....sss....................sssssC.......sss...hh...ss............hs...h.........hs.....s...s...ssPsssCCssl+s..h.....h.t.sp..ssClCthhss.s..............ts...h.sls.hspuh.tLs.ptCsls..sss.....tC	.................................................................hhh......................ts..........................ss.s.s.sC........ssp.....Lh...ss.................hs...h.........ls............s.s.....ssPossCCsslcs..h....................t......ss...........tCLCthlpsss...........................hs..h.sls.h.s..pAh.t.l.P.stCslsss......C..................................	1	104	420	582
+14211	PF14369	zf-RING_3		zinc-finger	Coggill P	pcc	Jackhmmer:A0MEB9	Domain	\N	29.60	29.60	29.60	29.70	29.50	29.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.81	0.72	-8.18	0.72	-3.95	96	381	2011-06-13 12:47:51	2011-06-13 13:47:51	1	8	114	0	221	364	0	33.60	39	9.85	CHANGED	spYWCapCsphVpl..t..tss........s...CPpC.s.u.GFlE...El	...paaCapCsp.Vph..t....ssh.......h....CPpCp.u.GFlEEl....	0	46	116	169
+14212	PF14370	Topo_C_assoc		C-terminal topoisomerase domain	Coggill P	pcc	Jackhmmer:B3H4K2	Family	This domain is found at the C-terminal of topoisomerase and other similar enzymes.	25.00	25.00	27.80	27.80	23.30	23.10	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.40	0.72	-4.32	47	743	2011-06-13 13:44:24	2011-06-13 14:44:24	1	10	600	16	275	707	30	65.80	64	12.18	CHANGED	lcc+lcphplphpsK--NKpVALGTSKlNYlDPRITVAWCK+a-VPIEKl.FoKTLRc....KFsWAhcs....cpcap....F	....................L.c-QLhKLElQtTD+.....-ENKslALGTSKLN...YLDPRISVAWCKKa-VPIEKI.aN.......KT.R-..................KF.WAht.........................	0	90	146	221
+14213	PF14371	DUF4412		Domain of unknown function (DUF4412)	Eberhardt R	re3	Jackhmmer:Q8KCD3	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 75 and 104 amino acids in length.	28.70	28.70	28.90	28.80	28.30	28.60	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-9.94	0.72	-3.47	91	199	2011-06-13 13:44:51	2011-06-13 14:44:51	1	7	134	0	99	199	11	89.20	21	35.07	CHANGED	hpchG.scslsGhpCp+hcl................tssptptph...Whop-...............................................tGhPlchptpsssssh................htslchpsh.ssuhF..plPs.GYp	..........pchG.scslsGhsCpcaph.....................tssptpsph...WhopD...........................................................................................Ghslphptpssss.s...t.......................hhplphts..ssuhF..plPs.GYp....................	0	51	80	93
+14214	PF14372	DUF4413		Domain of unknown function (DUF4413)	Coggill P	pcc	Jackhmmer:	Family	This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.	27.00	27.00	27.00	27.00	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.38	0.72	-4.03	79	377	2011-06-13 14:32:42	2011-06-13 15:32:42	1	27	37	0	208	358	0	97.30	25	17.07	CHANGED	lSusphPTuNhaapplhclct.......hL.pc..h.p.sp...-.s.h.lp.s.hspsMppKFcKYW.......c......phshh....LslAslLDPRhKh....p.h...lcathpph...aGp...c.sp...ph...l.pcVcsslpcLappYp	.......................................................ss..sTus.hhh.phhplph..........................hL...pp...h...t..sp.......s..h.lp.s..hsppMpp.......KFcKYW..........................p............phshh....lslAslLDPRaKh....c.h...lcathpph......hut....c...st...ph...lpplpptlpplappY..................................	0	9	80	136
+14215	PF14373	Imm_superinfect		Superinfection immunity protein	Eberhardt R	re3	Jackhmmer:Q8KCM5	Family	This family includes the E. coli bacteriophage T4 superinfection immunity (imm) protein, Swiss:P08986. When E. coli is sequentially infected with two T-even type bacteriophage the DNA of the superinfecting phage is excluded from the host, into the periplasmic space. The immunity protein plays a role in this process [1].	27.00	27.00	27.20	27.20	26.80	23.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.03	0.72	-4.32	60	264	2011-06-13 14:42:33	2011-06-13 15:42:33	1	5	229	0	62	205	39	42.80	40	38.53	CHANGED	lYFlPsllAhhRp..+ppthsIhllNlhLGWThlGWlsALlWAlp	..........lYFLPsllAhtRc..+psphsIhllN....lhhGWThIGWllsLhWuh.........	0	17	30	48
+14216	PF14374	Ribos_L4_asso_C		60S ribosomal protein L4 C-terminal domain	Coggill P	pcc	Jackhmmer:Q9C6F1	Domain	This family is found at the very C-terminal of 60 ribosomal L4 proteins.	27.00	27.00	27.20	28.20	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.60	0.72	-4.10	64	472	2011-06-13 14:55:20	2011-06-13 15:55:20	1	6	336	8	266	449	5	78.60	42	21.13	CHANGED	psYpLPpshhsNsDLsRlINS-EIQullRsPptpspp+...ltKKNPL+Nhpshl+LNPYAtsh++pplhsppppttt+ttt	......psYsLPpshMsNsDLoRllpSsEIQpslRss.......+ppsp++......shK.KNPLKNhplhL+.LNPYApsh++ptlhtpttphttp...h.............................	0	101	154	217
+14217	PF14375	Cys_rich_CWC		Cysteine-rich CWC	Eberhardt R	re3	Jackhmmer:Q8KFY4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 74 and 102 amino acids in length. It contains eight conserved cysteines, including a conserved CWC sequence motif.	24.00	24.00	25.10	25.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.19	0.72	-4.04	76	321	2011-06-13 15:01:50	2011-06-13 16:01:50	1	4	317	0	117	296	51	50.50	33	57.01	CHANGED	CPhCGsshpCu...........ttstssCWCsshshs.shh......tth.t.......................psClC.sCLpph	.........CPtCGpshpCs............tss.tsCWChs..hshtsshh......tth.tth.....................psCLC.pCLpp.h..	0	25	54	87
+14218	PF14376	Haem_bd		Haem-binding domain	Eberhardt R	re3	Jackhmmer:Q8KBS9	Family	This domain contains a potential haem-binding motif, CXXCH [1]. This family is found in association with Pfam:PF00034 and Pfam:PF03150.	27.00	27.00	27.40	37.50	26.80	25.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.79	0.71	-4.48	89	710	2011-06-14 08:17:18	2011-06-14 09:17:18	1	4	650	0	123	370	30	137.10	48	34.47	CHANGED	llshlslQhhshpps...........ssshtp.hpsspplptlhcpuChDCHSspTpaPaYuplsPsuahlppclpcG+cphNhopatsh...........spptppscLsclhphlcpscMP.tpY..hh..hH.pAcLopp-+ptllsWlpptp	.................................h.lsYLGLuGYVaaaDppRucp...ucspu...SsluENsclluhl+EKGCDYCHTP.S.A.ELPh.YhhlPsAKQLMDYDIchGhKu..F....NLE..sVcuAL........hsspPVspS-L..sKIEhVhphpTMPPoRY..sA..L..HWuu+lSD-ERs-ILsWIucQR......	0	33	82	109
+14219	PF14377	DUF4414		Domain of unknown function (DUF4414)	Coggill P	pcc	Jackhmmer:	Family	This family is frequently found on DNA binding proteins of the URE-B1 type and on ligases.	26.00	26.00	26.00	26.00	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.90	0.72	-4.13	25	383	2011-06-14 09:48:55	2011-06-14 10:48:55	1	45	242	0	276	400	2	103.50	29	3.48	CHANGED	IDPsFLtALPE-lRcEVltppls............t..p...sssspsss-lss...........EFLsALPs-IppElLpQEptpppRppppttsp..............ss-MDsAShlATlPPsLRcpVLh-psE	......................lDPpaLsALP-DlRpEV...ltpp..ht.ptsp.................t..p.......sss.....ss...t..ss-lsP.........................................................EFLsALPs-lppElLtQpptppp.ppp...ttttt............................................................hD.sshh.sh...tlRtthh.........................................................	0	75	144	227
+14220	PF14378	PAP2_3		PAP2 superfamily	Coggill P	pcc	Jackhmmer:Q9LVZ7	Family	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.27	0.71	-4.78	12	684	2012-10-02 00:53:37	2011-06-14 15:22:55	1	10	432	0	300	1471	163	172.80	19	49.31	CHANGED	shslhsh-cslthshptsLpph.lsp+PhL.slhush..sohhhththhhlhashhsc.s+hRshhshhhhhshhullshshh.shPs....phLsst.sF.s.hhshsssuha..th.t.h..............hhPShHsuhAhhsulshh+.hthhthhh.lssshsllhslsllustsHYhlDhssGssluhlhhtL	.................................................................................................................................h.........................h.......h................h...hhshh..Y........h...h..h.....h..h.h.h..h..l.h...h.....h..h...h...t....c....t..p..............h....p....t....h.....h..t..sh.h...hs..s....h..h..uh..l...h...a.h.....ha.P.s.s...PP..............................th.h.............................t.......s......h..............................s....h....h....t..........s......h..s.s.h.......s....h....h...........................t.........h......tth.......................ss.h...s..A...hPSlH....s.u...h....u....l....h..h......u...l.......s.......l..........h.....p.....h.....t...........t.............t.............h.........h..............h...h....h.........l....h.h....h.a.sh.h.h.hh..s..sls..s..upHYhlD.s.lu.Ghhhshhh...hh......................	0	97	194	260
+14221	PF14379	Myb_CC_LHEQLE		MYB-CC type transfactor, LHEQLE motif	Coggill P	pcc	Jackhmmer:Q9LG13	Family	This family is found towards the C-terminus of Myb-CC type transcription factors, and carries a highly conserved LHEQLE sequence motif.	27.00	27.00	29.00	29.00	26.90	26.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.69	0.72	-4.38	46	474	2011-06-14 14:51:50	2011-06-14 15:51:50	1	10	53	0	259	459	0	49.60	52	15.20	CHANGED	uhpls.EALc....hQhEVQ++LHEQLE..lQ+pLQ.lR.I......EupG+aLppllEctpcshu	...............hpls.EAL+........hQMEVQ++LHEQ..LE........VQRpLQ.LR.I.......EAQGKYLQpllEctpch..s......	0	43	156	213
+14222	PF14380	WAK_assoc		Wall-associated receptor kinase C-terminal	Coggill P	pcc	Jackhmmer:Q5XVH3	Domain	This WAK_assoc domain is cysteine-rich and lies C-terminal to the binding domain, GUB_WAK_bind, Pfam:PF13947.	27.00	20.00	27.00	20.20	26.90	19.80	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.86	0.72	-3.48	53	366	2011-06-14 15:07:24	2011-06-14 16:07:24	1	27	20	0	205	376	0	92.30	23	22.47	CHANGED	hsCssps.....s..st.....sh.hh...h........s...s.................s....s.........hsttCppsltlPVhssth..tt.tt.......ssss...htpsLcpGFpLpWp......tsssCppCts........SuG.pCGasps.........s.ptFsChCsDsh	...........................................................................................................t.....h.ttC..p.....h.lPV...tt..h.t..t...........s.ss....htpsLppGFpLpap.....sssCppCps........S..GG.tCGasps...........t..tta.tCh.Csst...................	0	22	113	156
+14223	PF14381	EDR1		Ethylene-responsive protein kinase Le-CTR1	Coggill P	pcc	Jackhmmer:	Family	EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation [1].	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.55	0.71	-4.75	46	364	2012-10-10 12:56:15	2011-06-14 16:27:23	1	45	119	0	219	341	1	179.40	30	21.50	CHANGED	sssu-slSpRaWspssLsY...t-KlsDG..FYslhGh........t.....pts+hPSLpsLcuhs.s.s..ssshEllLVDRptDspLpcLcphAhsls......pss.....ss.ss.....ptllp+LApLVsspMGGssts.sps.hhs....p.Wpp..op...L+s...ppusls..lGpLslGLsRHRALLFKVLADsl.....slPCRLVKGs..su..........c-suhslV+hs.s....sREalVDLhusPGsLh.P	........................................................................................hu..hh..s..ls.....p.l.sG..FY.lhs...........................................phPsh.pL...pt......tt.th-slllst...D.tL.t.l.phs.t.hh..........................ts..........ss.....tthlppLAplVscpMG...........Gss.....s..tp..hhh........pap....hSp......ph+p.........psssls..lGplp....hGl.sRHR.ALLFKlLADpl.......s..l.PC+LV+Gphhsu..............pstshsllt..ht.s..............sp...E.....alVDLhttPGpLh....................................................	0	41	119	175
+14224	PF14382	ECR1_N	ECR11_N;	Exosome complex exonuclease RRP4 N-terminal region	Coggill P	pcc	Jackhmmer:	Domain	ECR1_N is an N-terminal region of the exosome complex exonuclease RRP proteins. It is a G-rich domain which structurally is a rudimentary single hybrid fold with a permuted topology.	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.24	0.72	-7.74	0.72	-4.66	79	613	2011-06-14 16:29:30	2011-06-14 17:29:30	1	16	360	11	439	594	35	39.40	35	14.59	CHANGED	lllPGp.hLus.s.s.pa.h.s.GpGTYh......cs.splhASlsGhlplss	....llsPG-.hls......s.s.s.p.....a.h...t.GcGTYh.......................ps..s......plhuSluGhVph.......	0	131	226	350
+14225	PF14383	VARLMGL		DUF761-associated sequence motif 	Coggill P	pcc	Jackhmmer:Q1PFF9	Domain	This family is found frequently at the N-terminus of family DUF3741, Pfam:PF12552.	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.41	0.72	-7.56	0.72	-4.78	10	212	2011-06-14 17:36:40	2011-06-14 18:36:40	1	5	19	0	148	189	0	29.80	43	3.81	CHANGED	suosssscuhuh+uPulVARLMGLDSlPssppsp	.........t...............+sPulVARLMGLD.uLPs............	0	20	93	122
+14226	PF14384	DUF4415		Domain of unknown function (DUF4415)	Eberhardt R	re3	Jackhmmer:Q8KF70	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 82 and 104 amino acids in length.	26.10	26.10	26.10	26.30	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.08	0.72	-3.81	196	801	2011-06-15 08:14:51	2011-06-15 09:14:51	1	2	572	0	237	649	74	66.50	32	69.83	CHANGED	Dhsphsct...tpht..............................................Kp.p..lolRlDsDV.....lcaF+u..p.GcG......aQo+lNtsL......Rchh	.................................................-.s..sct.h.tpAp.ht.....................................hhpPh.....sKp.p..lolRlDsDV.....l-aF..Ku.....s..GcG......aQoRlNthLRchh..............	0	53	137	182
+14227	PF14385	DUF4416		Domain of unknown function (DUF4416)	Eberhardt R	re3	Jackhmmer:C9RKS1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 176 and 187 amino acids in length. There is a conserved DPG sequence motif.	27.00	27.00	43.60	96.40	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.83	0.71	-4.53	29	85	2011-06-15 09:02:56	2011-06-15 10:02:56	1	2	82	0	53	88	19	163.40	33	87.51	CHANGED	tst.spLlh.slhss...pphhpp..lhttLpc+FGsl-hhSs.hsFc.aTsYYpcEMG.sslh..++hluFccLls.-pLs-lKlhTNplEppaut.cup....RplNlDPGYlstpplVLAosKsasHRlYLscGIaA-lTLhYppGc.apshsWTYPDYpspphtpaLsplRch..Y	.........................h....spLlh.ulh.hs...cthhpp..lhstLpppFGslchhSs.hsFp.aTsYYpc.EMG.ps..Lh..++hluFccLlp.ppLsclKhtosplEcpaup..puc....RplNlDPGYlstpplVLAosKsasHRIYLscGIYAElTLhYpcGc.apshsWTYPDY+spchtpahpplRchY......	0	29	46	48
+14228	PF14386	DUF4417		Domain of unknown function (DUF4417)	Eberhardt R	re3	Jackhmmer:C9RLL4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 220 and 340 amino acids in length. There is a single completely conserved residue G that may be functionally important.	27.00	27.00	31.00	30.60	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	201	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.13	0.71	-4.98	22	148	2011-06-15 09:37:46	2011-06-15 10:37:46	1	2	121	0	11	123	1	194.50	25	76.35	CHANGED	pll.p................h.hsuphclPhlt.sphhsts................hlsFshtpppcp.....................pstslHFalcDhpFcclassPc.......phlppLpp..apulloPDaSlYhDhPhshQlaNhYRs+hlutahQppGlpVIPslsWuspcoa.......casFcGl.sctuslAloohG.....phpspcpcphFhpGhpchlp+l.pPtplllYG....th..pphass.....hpllphpsatpp	...........................................................p.......h..psthplPhlp.sphhs.t................hhsashhtpp.p...............................psshlHFahcDhpFcp...laspsc.......phlpclpp.......asullsPDaSlahD......hPhshplaNhY+sRh.lutahQ.ppGlpVIPslsWuspcoa.......casFcGl..ctuhh..AluohG.....hhpsppphphahpGlpchlc+l.pP.phlll.YG.....th..c.hatp..t..hphhph.sh...p...........................................	0	6	9	11
+14229	PF14387	DUF4418		Domain of unknown function (DUF4418)	Eberhardt R	re3	Jackhmmer:C9RQ28	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 132 and 150 amino acids in length.	27.00	27.00	43.30	43.30	24.30	24.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.07	0.71	-4.38	32	145	2011-06-15 10:24:38	2011-06-15 11:24:38	1	1	133	0	26	122	2	125.30	29	87.92	CHANGED	hl.lllGlLlslsPhh.hhslCss..h.tst..................hMtCaasupAhhslGsllhllullhhhh..ppthchuLslsshshulls...hLlPshl...............IGlC.ttstMtC+sh.ohPslhllullhllhuhhs...hahpcc	..........h..tlllGlllsluPph.hAssCts..h.pst.....................................hMtCaaoupushslGllIhllullhlhl..sttl+huLsluslslulhs...hllPssl...............IGlC.ttstMpC+sh.ThPhlhllullhllhusls...lahpp.p.......	0	17	19	22
+14230	PF14388	DUF4419		Domain of unknown function (DUF4419)	Eberhardt R	re3	Jackhmmer:C9RQB5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria, eukaryotes and viruses. Proteins in this family are typically between 348 and 454 amino acids in length.	25.00	25.00	26.90	26.70	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	299	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-12.12	0.70	-5.20	59	188	2011-06-15 10:35:06	2011-06-15 11:35:06	1	7	78	0	151	195	7	271.50	28	70.40	CHANGED	ssuFlpu.shpAYupHhsLhlpPD-lWhsIlsphuhalsspu..EpLRphFVsa.cGKcpLhVp....stssh.p..............sasplh.chsppIpcpltss.h....cchhh..s.sFSTTTtsD+lsuslshMush+pYFcYp.......hhhhCGlPs..........VTLLGph-DWppLtp+lc+Lt-.....as.p..............hppWt.phLpPllccFlpohcsps....s.......hpFWspIschpus...uuGssh..l......oGWIosFhhasp..pGphhttttt............................................................ts.h.hlshpplPsGhsplPlplp...s.stt...hptphhuGhhGhph.....ppp............................psslpPthsWhlh	...................suhlpuhhpAYspHptLhlcPD-lWhsIhpQhshal....Ntpu..E..plRphFVsa..pG.KcpLhVp........ssh.p..............satthh.phsppI.pppltss.l.......tshlh...P.sFSTTTtsDphsuslhhMu.sh.ppYFpat.........hhhhCGl..Pp..........lTL.GphpDWtplhp+lccLt-.......as.t...................hptWh.phLpPllcpFlpuhcsss........s............hpFWpplhchpst...........huGssh.....l.....sGWl.ssFhhaspcGph.t..................................................................................h.hls......hpplPsuhspsslhhp...p..t......h.h.hhuGhhGhph.....pp............................t.slpP..sWhh.............................................	0	78	120	139
+14231	PF14389	Lzipper-MIP1		Leucine-zipper of ternary complex factor MIP1	Coggill P	pcc	Jackhmmer:A8MS81	Family	This leucine-zipper is towards the N-terminus of MIP1 proteins. These proteins, here largely from plants, are subunits of the TORC2 (rictor-mTOR) protein complex controlling cell growth and proliferation [2]. The leucine-zipper is likely to be the region that interacts with plant MADS-box factors [1],	26.00	26.00	26.00	26.40	25.80	25.60	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-9.98	0.72	-3.88	39	340	2011-06-15 10:44:33	2011-06-15 11:44:33	1	11	25	0	185	326	0	83.90	31	13.80	CHANGED	pcpps.p..pp+t....sLEp-VtpLpcpLpcEpslRtsLEpAlsp.......ssus.hsp.hst.plPppspELlpEIAhLEt-VspLEppl.sLttplhppp	.............................t......ppt+.sLpp-.VppLpcpLp.pEpsl+tuLEpA.hst.....................s.us...hsp...ss..hlPspsp-LltElAlLEtEVs+LEppllsLppplhpp...................................	0	35	109	149
+14232	PF14390	DUF4420		Domain of unknown function (DUF4420)	Eberhardt R	re3	Jackhmmer:C9RS82	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 310 and 334 amino acids in length.	27.00	27.00	33.00	32.70	19.40	18.60	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.77	0.70	-5.58	41	142	2012-10-11 20:44:47	2011-06-15 11:48:59	1	1	139	0	58	155	70	293.10	20	92.56	CHANGED	pplpphWpplptp........t.thstphlptstt.hslhluhshpsphthhl..............hshthhsphsphpuhc.lp.......t.tttphhlslphpsss.hpclFstlssDllppl...t.pstpphhpshhtplpcWpcLht..tttpslopcp.hGLhGELhhLcp..h.sthsspts..lpuWsGPptsppDFphss..sslEVKooh..psspplpIou.cQ.L-ssstt.....LhLshhtlppsss....Gh.olscllsclpphl...t..tshptapp+Lh.phGYh.tpt....htphpatlpphch.apVc-.sFPRlspss.....lP.pulsslpYpl-Lss	...........................................................................................................................t............................hh......hthhhuhs...s.p.thhh.....................tph.sphpshp.lth................tttthhltlhh.tptt....tclFttlspsllppl.......tstpphhpshhpplppWpplht..tttptLspcp.hGLhGELhhLcp...l....tthsssss...lpuWpGP..ptsp....pDFphss..tslEVKooh..p..pspplpIuu.cQ..Ls.sstss........LaLhshplppsss....Gh..oLs....s...llpplpptl...ttspshptFpptLh.phGahstpt....htptpa....tl.ps.h....ph...apVs.c.sF.P+lspss......lP..pulsslpYplsLs.t................	0	17	45	52
+14233	PF14391	DUF4421		Domain of unknown function (DUF4421)	Eberhardt R	re3	Jackhmmer:C9RSA4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 336 and 370 amino acids in length.	27.00	27.00	27.40	27.10	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-11.69	0.70	-5.22	31	119	2011-06-15 10:56:27	2011-06-15 11:56:27	1	1	103	0	25	121	5	295.50	33	84.70	CHANGED	sphDTs...........YIcspcas.hshhlpssssh.Ehaplsssp................tpslshsPsssh+lGshhuaRala........LGaohshptlt.tppspspppphslsL....Yos.+lulDlaY++ssu.Yphpphphts..t..s....shsF.sshpsphhGhNlaYIFNp+.+FSYsAAaSQSshQ++SAGShlhGhuastaplphshstlst.hppp..h................ththpphcahshslusG..YuYNWVFu+.salhss..SlssuluYp.sh.php.pp.tt.sshphpshshchluRhGlsaNss+aauGhShlhcsasYpcpsao....ssshF...GslslYsGa.....pF	...........................................................................................................t.phDTs...........YIpPp+YN.aslMlppsssa..EhYplsspp.................QplsFuPsssh+..lGhYFGWR..WIF........LGaolDlsplh..pppcs+tp-hsLSL.....YSu.clGlDlaYR+TGssY+l+phphhs...phssp.....stsF..sGlpsph+GhNlYYIFNp+.+FSYPAAaSQST.QR+SAG...ShlsGhuhopHpLshDaspLsthlppp..ht........................shthpclKYsshulssG..YuYNWVFA+.Na.Lhsh..SLssuluYKts.h...ph...pppp....sphhhp.shNh...DhlsRhGlVYNss+aasGhShlh+sYsYc+s.sFS....hsNhF.......GslplYsGaNF..........................	0	15	24	25
+14234	PF14392	zf-CCHC_4		Zinc knuckle	Coggill P	pcc	Jackhmmer:Q9SHW6	Domain	The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. This particular family is found in plant proteins.	27.00	6.00	27.00	6.60	26.90	-999999.99	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.15	0.72	-8.58	0.72	-4.29	79	629	2012-10-03 11:39:54	2011-06-15 13:56:05	1	98	80	0	325	3156	20	38.20	30	8.98	CHANGED	lcls+PLpptltlp....hs...ss...p.p..th...hplcYE+lspa.ChhCGhlGHspp..pCst	...............................................................................h.h.YEhh........h..Ch.pCsthGHstp..pC........	0	67	167	281
+14235	PF14393	DUF4422		Domain of unknown function (DUF4422)	Eberhardt R	re3	Jackhmmer:C9RPD5	Family	This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 255 and 371 amino acids in length.	25.00	25.00	29.50	29.50	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	231	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.66	0.70	-4.76	90	376	2011-06-15 13:10:07	2011-06-15 14:10:07	1	7	289	0	76	365	474	224.80	37	67.37	CHANGED	+IhlusHKphp.hP..pc.shYhPlpVGss.t...............p...........sahtDsoGD.NISp+NPtYCELTulYWAWKN...h.csDY.lGLsHYRRaF....shppp......................tthptllsppplpphl..p.pa..DlllP...c+Rp..ahlc..........olhsHYtcs.Ht.tccL-hscclIpcpaP...-Yhsua-plhpppp.uah..aNMFIM++clFcpYCpWLFsIL.ElEccl..Dh....os.YsshptRlaGalSEpLhsVWlp...p....pp.lc...htE	.....................................pIhlusHKpht...hP...ps.shYhPlpVGtshp....................sh..............shhtDso.....G.D.NISp...+NPhYCELTulYWAWKN....h..csDY.lGLsHYRRaFshppt..........................................tthphll.spp...p.l.pphL...p..ph..DlllP.......c++p.......ahhc..........ohhs...HYtps...Hp...tcsL-hscplIpcpaP...-Yhsua-p..hh.pppp..uah..aNMFlM++chFscYspWLFsIL.clEccl..Dh................os.Y.....sshptRlaGalSEhLhsVWlt....p....pp.h....t...........................	0	23	47	56
+14236	PF14394	DUF4423		Domain of unknown function (DUF4423)	Eberhardt R	re3	Jackhmmer:C9RKJ5	Family	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, and is approximately 170 amino acids in length.	30.00	30.00	30.80	31.50	29.80	28.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-10.62	0.71	-4.72	52	72	2011-06-15 15:22:47	2011-06-15 16:22:47	1	2	5	0	70	73	44	168.50	24	60.39	CHANGED	hhphsptpph+hlsscpacaapsWhpsllRp.Lsshhsss...ssttlActhhstlostclpcuLphLhchullc+sts.ssYtpTppsls.sst-shshul+shp+phhchAhcul-phshpcRshSulThulsccsaccltcplcchR.+clh...sluspp.pc.sccVYpLNlQLFPL	............................h...hhpttph+hlsscpacaappWhpsslRp.Lhshhsss.....ssttlAcphhstlostplccuLphLhchuhlc+sts..spat.oppsls.sstcshshul+shppphhchAtcul-phshpcRshSulThulsccsaccltctlpcFR.+clh...plssps.pp.scpVYpLNlQLFPl..	0	70	70	70
+14237	PF14395	COOH-NH2_lig		Phage phiEco32-like COOH.NH2 ligase-type 2	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A family of COOH-NH2 ligases/GCS superfamily found in the neighborhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis [1].	25.00	25.00	29.50	28.70	20.00	17.90	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.63	0.70	-5.33	8	44	2012-10-02 17:21:26	2011-07-19 19:39:50	1	2	41	0	16	48	0	234.20	36	50.04	CHANGED	osloLGADPEFMLppspGc.MlsAS.cFaspsGslGCDsp+lttc.....hPlAELRPuPspsPcpLltplcplLppAsphlsctslcWlAGuhPasGYslGGHIHFuGl.lohpLlRsLDsYLuLPLhhlEDPss.ttpRRp+YGaLGDaRhKsaGtFEYRTssSWLVSPtsA+AsLpLA+llAcpaccL.ppshhsschpcAFYpG-+chLtsplstlhp-lpuhssYsshtttI-.lashl-cGpoWDEcsDlRptW+IPhh.	.............lhlGhDsEFhLhp.psp.hl.AScah.s+tG.sGsDshphptch....hPlsElRPtPsssPttLhhplpphht.Att..hlsp....psl.WhAGuhPhtsaslG.GHIH..F..S...G.l...........sL.....sh....pLlRsL....DsYLALPLsLlEDsps..thRR.s.pYGhLGDhRtpsaG...GFEYRTLs.S.WllSPtls+uslslAhll..ApphtpLpt...psl.p..phpcAaYpGs.+thL+thh.tlhtcl..thstYtpa...........pt.lt.hhphlcptt.WsEptDlR.hWpl...s............................................	0	10	14	14
+14238	PF14396	CFTR_R		Cystic fibrosis TM conductance regulator (CFTR), regulator domain	Finn RD	rdf	Manual	Domain	\N	22.50	22.50	24.10	23.90	21.10	21.10	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.44	0.70	-4.97	9	137	2011-07-19 22:39:50	2011-07-19 23:39:50	1	9	75	46	32	131	0	200.10	67	15.53	CHANGED	DFSSpLhGh-uFDpFSAERRsSILTETLRRhSV.DtD..uusshsEsc+QSF+Q.......s.......G...-.....asEKRKsS.ILNPlsSsRKFSllQpu......QhsuhE-ss..cE.sER+hSLVP-sEQGEssLPRSNhh.ssGs.shpu+.RRQSVLsLMTp.S.pQGpphatptsuShR.KhSlsPQssL..SElDIYoRRLSpDSsh-ISEEINEEDLKECFhDDh-shs...ssTTWNTYL	.......DFSSKLMGhDSFDQFSAERRNSILTETLRRFSl...EGDAslSWsETKKQSFKQ...............T..............G.E.....FGEKRKNS.ILNPlNShRKFSlVQKTP.......LQMNGIE.Ess..-EPhERRLSLVPD.SEQGEuILPRuNll.soGP.ThQu.+.RRQSVLNLMT+.Sl.sQGQsl+++ssuSsR.KhSlAPQusL..oE.lDIYSRRLSQ-ouLEISEEINEEDLKECFhDDhEsIP...sVTTWNTYL.........	0	1	3	11
+14242	PF14397	ATPgrasp_ST		Sugar-transfer associated ATP-grasp	Iyer LM, Abhiman S, Burroughs AM, Aravind L	rdf	Manual	Family	A member of the ATP-grasp fold predicted to be involved in the  biosynthesis of cell surface polysaccharides [1].	31.40	31.40	31.40	32.50	31.30	31.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.79	0.70	-5.32	11	400	2012-10-10 13:17:03	2011-07-21 22:10:43	1	5	364	0	135	342	56	268.40	35	78.98	CHANGED	phhhppphtphs.....NspphhtlhccKshasph..hp-h..................hspchhshp....h.p.p-hptahpsp....pplhlKslsG.u.GpGlthhptss......................htpctpslhphhpssc.....pallpEtIpQHpthspLss.sSlNTlRllThhcs..spVclhhsllRhu..tuutssDNhus.GGhhsslDtsus..lpp.A.sh-.ptpta...phHPsotthhssapI..Phaspslphshcsupp.lPplthlGWDlAITspG.PllIEuNss.........sshs......h............ulhs.thsclhshphp	........................................................................................hth.....pRNhsalh+Y..NtR.phYslVDDKlhTK.h...A.p.t.Gh...........................h.hslp....tptplcplpph.....l.tsh.....ssFVIKP.A.p.GuG.GcG.IlVl.s.scptshahp.......ss..hs.pc..lpcc.....l.oshLsGLaSLuGp.......Dsul.lEphlp.cshFpuhSa..-GVPDlRlIl..........h...........pt...........hslhAMhRLu.....psuss.KA.....N.L...H.....Q...G...A...lG...VG.l....D.l.uTG..tlps.....s.........ph...s....p....l.................scH...PDTspplsslpl..PpW-pllpLAusshhE.hsGL.....GYlGsDhVLD.c-.c..GPhlLELNAR.......PGLsIQ.lANst............Glh.............pphtt............................	0	43	84	118
+14243	PF14398	ATPgrasp_YheCD		YheC/D like ATP-grasp	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the ATP-grasp fold predicted to be involved in the  modification/biosynthesis of spore-wall and capsular proteins [1].	100.00	100.00	105.30	105.10	93.00	92.90	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.47	0.70	-5.59	14	572	2012-10-10 13:17:03	2011-07-22 00:11:06	1	7	188	0	184	583	0	256.60	26	65.71	CHANGED	pphppt.th.has.shhsKWcVactLpcppplp.aL.PpTchhpshsslcphlspapplalKPhpGstG+GIhplpptpt...phhschpssptp..p.passhtthhshltpthsppcalhQQulsLhphpG+shDhRshhpKNppGpWploulssRlAupsplsoplssGGpstthpchhs.ct..p.....ppshtppLccsuhpluptl-cthssp....luELGlDlGlDspG+lWllEsNoKPu+pshpp....p..tpppohpp.lpYutaLs	........................................p.......th.hhs.......s..h..h.sK.WplaphLtpstplp.sa.L.PpTphh.pp.h..c...p...lp.phLppa...p.tlalKPhpGohG+GIhplptpp.......s............sahh..phppppp.....t..........hh.php.s.hp.p....L.hphl..p.....p.....h.h...p..t..p.....p.....YllQpG.IsLhph..sGcPhDhRlhspK.s.t.p.Gp.WploulsuRlus.ps.slsT.sl.s..sG.Gp.sth.h.p.phht..p......pc......ttplhpclcch...ulplupt...l-..cphst.....luElGlDlGlD.ppu.plWlhEs..No.K.Pu.+pshp.ph......t.t...p......p.shph.hpYuhaL.............................	0	94	141	147
+14244	PF14399	Transpep_BrtH	BtrH;	NlpC/p60-like transpeptidase	Iyer LM, Abhiman S, Burroughs AM, Aravind L, Eberhardt R	la_psag	Manual	Family	Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases. They are predicted to function as transpeptidases in peptide metabolite biosynthesis [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	317	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.78	0.70	-5.14	49	388	2012-10-10 12:56:15	2011-07-24 22:26:28	1	12	298	0	113	426	19	290.20	18	77.47	CHANGED	HCtosshssLL.phtGhtl.....sEshhFGLGuGLsahaht..hhphsh...hlssRst......phhpphtptLGhchp....hpphsssppuhctlcphlspGpsVhlt.sDhaaLsYhss...phHFsuHhlllhGhD..pcphhlsDs.spsshhpss............hssLtpARtupu.........shss+sphathpt....ssshss..ltpslh....pulppsspphlsss...................hGhpGlpphupcl.cW.....tspcphpthhtthhphhcch...............GTGGuhFRtlYupFLpcsuphhst.t.htphuphhpchuptWspl.ushhtphststp...tshpphuchlpplsctEcphhctLt	................................................................................C.sssht.hh.p.hGhth.....s-.hh.hhhstuhsh....hh.......pht....h..hshph........thhpphhph.lGh.php.....hpphs.s.......ppu.....h....p.tlcphLs....pG.hPVhl....t.hDhh..aL..s.......Yh..ss...................phph...............s.............s...HhlllhGhD.....ppthhl..t.....Ds........t...s...h.h...phs............hppltcAhtup.s..............hs..s.tshh.hthph...........st..p......hhptht.....pslpp.shp..phhsss.............................hGhtuhpphsppltp......h.......s.............tpphph.h...hh.......h.hthhtph.......................hR.hh.up.aLpchtt...h........h..p....hup....hhpphuphapth.thhhhc.......t.t.....pthtphuphltplsphEpphhp.h........................................................................................................................................................................................................	0	44	85	99
+14245	PF14400	Transglut_i_TM		Inactive transglutaminase fused to 7 transmembrane helices	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A family of inactive transglutaminases fused to seven transmembrane  helices. The transglutaminase domain is predicted to be extracellularly  located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The  ATP-grasp is predicted to modify the 7TM protein or a cofactor that  interacts with it [1].	100.00	100.00	106.50	106.10	91.80	91.30	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.88	0.71	-4.73	93	271	2012-10-10 12:56:15	2011-07-24 23:33:47	1	2	269	0	71	210	16	166.30	42	33.13	CHANGED	YRthshGlPhsPGEppplWslEA+lcFsAsGc.Pl+........VohslPphpsuasllsEsssS.sGYGl...........oh..hcsc.s.s..R..+Ap.W.ShRpAsGpQsLYY+splh.s.csps....chs...ths...sP.....................s...hssh.s..h.suP.ppsAA.psLlspspp+SADsho..........FspELI.Kpl.N..sss.sQNspLLLs.s..t....s.+	....aRt.shGlPhTPGETcplWslEA+l-FsApuc.slK........VShusP.pppuasllsEosuS.sGYGl...........Shhps-..u..sRRspW.SlRpA.sGsQTlYY+sphhscspu..cts..phs..ss.....................t.hss.s.h.-uP.EcsAApALlspspp+SADshT.....FspELIKplNssp.sQNspLLLsp......scsp...	0	20	34	56
+14246	PF14401	RLAN		RimK-like ATPgrasp N-terminal domain	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	An uncharacterized alpha+beta fold domain that is mostly fused to a RimK-like ATP-grasp and is found in bacteria and euryarchaea. Members of this family are almost always associated in gene  neighborhoods with a GNAT-like acetyltransferase fused to a  papain-like petidase. Additionally M20-like peptidases, GCS2,  4Fe-4S Ferredoxins, a distinct metal-sulfur cluster protein and ribosomal proteins are found in the gene neighborhoods. Contextual analysis suggests a role for these in peptide biosynthesis [1].	25.00	25.00	31.30	30.40	24.00	19.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.91	0.71	-4.71	87	317	2011-07-25 16:00:10	2011-07-25 17:00:10	1	6	294	0	83	259	20	151.70	37	31.83	CHANGED	osp-YLpps....htps...........+...spllNLC+sYpYhopGYYsSLLAEARGH+Vl.PoVpsls-.......LppppLhshshtplp..............................................phltptl.t..p............hssphhplp............laFGps..ptp..slcclARplF-tF.sPlLclphpcppp......................Wplpslps...hslscLscpcpshFtp..uL-	....................osppYLpps....hhst...........+..pspVINLCRsYpYhSpGYYsSLL.AEARGH+VI.PoVpsIs-.......lsptphhphslt.c.lc....................................................chh.p.lpp.............ss-shslp............lYFGps..stcsLccLARpLFEtF.sPlLclphc+pps.......................WpIpsIps.hshpcLp-scp-hFhpuL..................................	0	37	61	73
+14247	PF14402	7TM_transglut		7 transmembrane helices usually fused to an inactive transglutaminase	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A family of seven transmembrane helices fused to an inactive  transglutaminase domain. The transglutaminase domain is predicted to be extracellularly located. Members of this family are associated in gene neighborhoods with a pepsin-like peptidase and an ATP-grasp of the RimK-family. The ATP-grasp is predicted to modify the 7TM protein or a cofactor that interacts with it [1].	25.00	25.00	42.00	41.50	22.50	21.90	hmmbuild  -o /dev/null HMM SEED	315	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-11.98	0.70	-5.50	34	285	2011-07-25 16:28:49	2011-07-25 17:28:49	1	4	280	0	75	224	26	309.70	52	62.39	CHANGED	sphlhpLLspAsIPARhVpuLpLE.Du+RcQplpsalpVass.cc....WhhFsPpoGppGhP-shLlWppustsLL-lpGGpsupVsFShhppphsshphup..pptp.ssp..hhsF..SlasLPlcpQslFKslLLlPlGsLlVVhlRsllGlcTSGTFMPVLIALAFlpTpLlsGllhFlllVulGLllRuYLs+LNLLLVsRluuVllhVIhlhuhlSlluaKlGlspGLolohFPMlILuWTIERMSIlWEEcGs+-VlhQGsGSLhVAlluYLsMssshlpHLsFsFPtL.LllLAllLLlGpYTGYRLsELhRF+shhcs	................................................................s.hhppLLuhAtlPs+hVtsIpLE.DsR...R+Qolp.hlcVasG..pp....WllF.....NPpTGpQ.uhssN.hL.lWppussuLL-VsGGpNSQVpFShlspchss.pssp.....scspsss..hLsaSlauLPLE-QuhFKslhLIPIGALlVVhLRlllGLKTSGTFMPVLIAlAFlQTpLssGIluFlLIVuhGLllRSYLS+LNLLLVuRlSAVIIsVIllIulholluaKlGLscGLoIT...FFPMIILoWTIERMSILWEEEGu+EVhhQGuGSLhsAlLsYLuMosshlpHLsFNF.ulpLllLAhlLLhGpYTGYRLoEL+RFKsLsc-.............................	0	22	37	60
+14248	PF14403	CP_ATPgrasp_2		Circularly permuted ATP-grasp type 2 	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Circularly permuted ATP-grasp prototyped by Roseiflexus RoseRS_2616  that is associated in gene neighborhoods with a GCS2-like COOH-NH2  ligase, alpha/beta hydrolase fold peptidase, GAT-II -like  amidohydrolase, and M20 peptidase. Members of this family are  predicted to be involved in the biosynthesis of small peptides [1].	191.00	191.00	195.90	195.60	187.90	187.50	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.30	0.70	-5.83	6	58	2012-10-10 13:17:03	2011-07-26 05:57:10	1	2	52	0	30	57	2	428.80	25	95.00	CHANGED	LspAlAD.YculL..s.slthtuW.psLstchRuspLhaGsRPlsslh.............RPpllocsQY-lLp+sscplspAlpclspthLsss....ulRphLtLoPhEE+LlshDPGYhtsp.AtuRhDoFLolDGs.LpFVEYNA-SPuuh.AYtDhLAchFlshPshpEFpK+YsltPLPuRphhLcTLLssaRpuGusstcPplA.IVDWpu..sPstoEFEhFpcaFt.......-aGl.sVIsoPp-Lsa.RDGpLls...........GshPlslVa+RllTsEhLsHas...LsHPLVpAYtsGAlslVNSFRAcLlHKKulFALLoDEphcs.hsA--RuAl+sHVPWTRlVpPu.TTapstsIDLlsFAhANRE+LVLKPND-YuGKGlsIGWEsos-tWcpALppAhco.PalVQERVpIshpPaP..thscGcl.ht-h.VDscPaLFG..scVpGChsRLS...TsslLNlos.uGuTlPsFll--	........................h.....................tsa..th.tthctsthhht...sc.s.lstsa.............pPhhhsppshcphpphspplhpllp+lhpchlpss....phRchhshsst.ccLlhhs.GYsthl.shuRhDlFhs..t.ss...hpFsEhNsDuuuuh.scsctlsphhhph.shpcFtcc..aplp.shs..h..hp.hlcphhshYcp.hts.psppPplA.IlDaht...hsshsEFc..hFtchap.......cpGhsshIsssccLpa..csspLhs...........ss.h.lDhlaRRhVTs-llpphs...thcsllpAhtssslshlsSFpupllHsKhlFslLpD-p..spt..h..Lss-EpshIccHlPaTphlps............h-lhphshss+-chllKPsDtYuucGVhlGh-hst-cWcptlpc....shp....p....sallQEahph.s.ppth........th.p.-uc.s.....h.sphhhssu.salas...........tphsGshoRlG...sssllsssh.tshsssshhlp................................................	0	18	26	29
+14249	PF14404	Strep_pep		Ribosomally synthesized peptide in Streptomyces species	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	A ribosomally synthesized peptide related to microviridin and  marinostatin, usually in the gene neighborhood of one or more  RimK-like ATP-grasp. The gene-context suggests that it is further modified by the ATP-grasp. The peptide is predicted to  function in a defensive or developmental role, or as an antibiotic [1].	25.00	25.00	103.10	103.00	21.40	20.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.45	0.72	-8.89	0.72	-3.75	7	17	2011-07-26 15:33:21	2011-07-26 16:33:21	1	1	17	0	3	19	0	62.90	72	98.35	CHANGED	MpPFALNYARPAsthpsssPYsYDuuhQLNVLhDGRsAApD+ALLtclGTTTSTAGSKTHFDD	MQPFALNYARPAsph-sssPYsYDSGLQLNVLhDGRlAAsD+ALLRElGTTTSTAGSKTHFDD	0	1	3	3
+14251	PF14406	Bacteroid_pep		Ribosomally synthesized peptide in Bacteroidetes	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to\	a papain-like domain. It is often present in multiple tandem  gene copies. The gene contexts suggest that it is modified by the  ATP-grasp as in the biosynthesis of microviridin and marinostatin.  They might function in defense or development or as peptide antibiotics [1].	25.00	25.00	34.10	39.50	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.51	0.72	-3.81	17	17	2011-07-26 16:09:42	2011-07-26 17:09:42	1	1	5	0	0	17	0	50.80	32	80.28	CHANGED	MKKLsthp.S..hhpNpKLsstptpultGG.hpsthpphs.....hsssc.s+DsDsh	MKKLsthp.S..hhpNpKLsstptpultGG.hpsthpphs.....hsssc.s+DsDhh..	0	0	0	0
+14252	PF14407	Frankia_peptide		Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide linked to cyclases in chloroflexi.  It may have a link to cyclic nucleotide signaling [1].	48.00	48.00	48.70	48.50	41.00	36.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.77	0.72	-4.21	10	16	2011-07-26 16:57:07	2011-07-26 17:57:07	1	1	13	0	10	14	0	60.90	37	80.85	CHANGED	plE+lIGRAVoDssFRppLlsDucp......Ascs..YDLTsEELcAL-clcsssLpuhAtsLDtcLs+	.thEclIGRAVsDssFRppLlssscp......Ascp..YcLTsEELcAL-phcssshpshAtplD.plp+.........	0	6	10	10
+14253	PF14408	Actino_peptide		Ribosomally synthesized peptide in actinomycetes	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp and an aspartyl-O-methylase. Gene contexts suggest that it is further modified by the ATP-grasp  and the methylase. It might function in defense or development, or  as a peptide antibiotic [1].	25.00	25.00	28.00	30.10	24.80	18.40	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-9.06	0.72	-4.04	16	32	2011-07-26 17:11:13	2011-07-26 18:11:13	1	1	26	0	15	34	0	61.30	36	65.68	CHANGED	sPhssss.........lDPsTQhulhsDphG.pllE.hGKH.GTussstTsosTss..DGps...ptss-sDospD	.................Phssss.....lDPsTQhuhhhDptG.pls-.hG+H.GTuosspTsTsTus..DGps...spssDp-sspD...........	0	2	12	13
+14254	PF14409	Herpeto_peptide		Ribosomally synthesized peptide in Herpetosiphon	Iyer LM, Abhiman S, Burroughs AM, Aravind L	la_psag	Manual	Family	Ribosomally synthesized peptide that is usually in the gene  neighborhood of a RimK-like ATP-grasp, and an ABC ATPase fused to a papain-like domain. It is often present in multiple tandem gene  copies. Gene contexts suggest that it is modified by the ATP=grasp. It might function in defense or development, or as a peptide antibiotic [1].	50.00	50.00	50.60	50.00	28.70	27.20	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.07	0.72	-8.98	0.72	-4.21	6	8	2011-07-26 17:54:10	2011-07-26 18:54:10	1	1	1	0	8	8	0	57.80	39	73.45	CHANGED	MEFcsh...KTEElPlI.....FGLTYLEEEAAEIsDVVGCLMPIDG..YosTGCDDSDts.....IP	Mchcsh...+hp-h.lI.....FGLTYLEEEAAEIsDVVGChhslDG.uYosTuCDDuDt.......P..............	0	8	8	8
+14257	PF14410	GH-E		HNH/ENDO VII superfamily nuclease with conserved GHE residues	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	A predicted nuclease of the HNH/EndoVII superfamily of the treble  clef fold which is closely related to the NucA-like family. The  name is derived from the conserved G, H and E residues. It is found in several bacterial polymorphic toxin systems [1]. Some GH-E members preserve the conserved cysteines of the treble-clef  suggesting that they might represent potential evolutionary  intermediates from a classical HNH domain to the derived NucA-like  form [1].	25.00	25.00	25.60	25.60	24.20	24.20	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.33	0.72	-3.83	51	101	2012-10-05 18:28:12	2011-07-27 20:41:42	1	24	88	0	22	106	0	70.40	29	13.00	CHANGED	sssGphhs...ssstpsl...............sphDMGHp...uhcatchhtph.pht..hopcEhp-ahp.sPcNYRlEp...sosNRS+ttE	........................t..pG.hhs....tstp.l......................t.hDhGHp....uhcapchhtth.p..tt..hopcphh-ahp.sPcsaRlEp...sSsNRSHtsE..	0	8	12	17
+14258	PF14411	LHH		A nuclease of the HNH/ENDO VII superfamily with conserved LHH	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	LHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, LHH. It is found in bacterial polymorphic toxin systems [1] and functions as a toxin module. Like WHH and AHH, LHH nuclease contain 4 conserved  histidines of which, the first one is predicted to bind metal-ion  and other three ones are involved in activation of water molecule for hydrolysis.	23.30	23.30	23.30	29.10	22.70	22.80	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.01	0.72	-3.77	25	102	2012-10-05 18:28:12	2011-08-10 22:52:37	1	25	88	0	22	112	2	81.20	35	12.15	CHANGED	TNhchhp...pGpuPhs..psG..cslpLHHlsQppsGPlsElopspHc...tspphLHshtpsups.......cspasp.+psYWKtRupphht	..........TNl-hMp...pGpAPls..pDG..pslpLHHltQcpsGslsElopstH...p...........tt....pphLHthhpss.psh.......+spFsp.RppYWKhRApp..p...	0	3	9	12
+14259	PF14412	AHH		A nuclease family of the HNH/ENDO VII superfamily with conserved AHH	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	AHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif, AHH. It is found in bacterial polymorphic toxin systems [1] and functions as a toxin module. Like WHH and LHH, the AHH nuclease contains 4  conserved histidines of which, the first one is predicted to bind  a metal-ion and the other three ones are involved in activation of a water molecule for hydrolysis.	18.20	18.20	18.30	18.20	18.10	18.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.79	0.72	-10.76	0.72	-4.07	49	340	2012-10-05 18:28:12	2011-08-11 01:08:44	1	41	221	0	113	345	45	106.40	19	19.54	CHANGED	spth..pttshtts...tshpuHHIlspps..........hhsttcplhcchGlc...........lssstNhlhlst........................hHp..GsHspp.....YpptVtcclppspp...............sppthhcpl.ppltccltsst	.......................tt...................shpsHHllspp................hh.th.p..pllpchG.hc...........lssspNtlhLP...........................................hHp....GtH..spt.........Ypphl.tppLpphpp..................ttsppthh...ptl.ppltpph............................................................	0	29	46	89
+14260	PF14413	Thg1C		Thg1 C terminal domain	Anantharaman V	la_psag	Manual	Domain	Thg1 polymerases contain an additional region of conservation  C-terminal to the core palm domain that comprise of 5 helices and two strands [1]. This region has several well-conserved charged residues  including a basic residue found towards the end of the first helix  of this unit might contribute to the Thg1-specific active site [1]. This C-terminal module of Thg1 is predicted to form a helical bundle  that functions equivalently to the fingers of the other nucleic acid  polymerases, probably in interacting with the template HtRNA [1].	26.30	26.30	26.70	26.60	26.00	26.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.85	0.71	-4.42	152	419	2011-08-11 14:39:21	2011-08-11 15:39:21	1	10	336	8	274	424	17	123.10	34	44.55	CHANGED	stpplpDYhsWRQ.sDsHlNNLYNssFWsLl.csGhospcApppLpGohuu-KpElLFpchGINYNs.P.tha++Gohlh+.................................................................................tt..pt.ttt+p+....pthhshat...........Dhh...ppFhcph..h..	........................................ppl+DYhuWRQ.sDs.............HINN.....LYNTsFWtLl...puGhospcApppLpGThuu-KN....ElLFpcaGI.NYN.s..Ptha+KGoslh+........................................................................................................p.......p..pt......pp.tht+p+....tt.hsha..........chht..ptFWpp.....p................................................................................................................	0	90	164	224
+14261	PF14414	WHH		A nuclease of the HNH/ENDO VII superfamily with conserved WHH	Zhang D, Iyer LM, Aravind L;	la_psag	Manual	Family	WHH is a predicted nuclease of the HNH/ENDO VII superfamily of the  treble clef fold. The name is derived from the conserved motif WHH. It is found in bacterial polymorphic toxin systems [1] and functions as a toxin module. WHH is the shortest version of HNH nuclease families. Like AHH and LHH, the WHH nuclease contains 4 conserved histidines of which the first one is predicted to bind a metal-ion  and other three ones are involved in activation of water molecule for hydrolysis [1].	25.10	25.10	25.20	25.20	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.33	0.72	-8.40	0.72	-4.74	35	277	2012-10-05 18:28:12	2011-08-11 20:50:36	1	34	251	0	50	331	2	44.80	34	6.85	CHANGED	tttppspuaTWHHppcs......ssMQLVspslHst......htHsGGhuhhpst	.....s..htpspGaTWHHh.s-s........ssMpLVspphHps............htHs...GGhuthpt.t...	0	11	27	38
+14262	PF14415	DUF4424		Domain of unknown function (DUF4424)	Bateman A	agb	Jackhmmer:Q7P768	Domain	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 310 and 361 amino acids in length.	27.00	27.00	29.60	27.00	23.90	25.40	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-12.02	0.70	-4.88	97	165	2011-08-18 09:52:12	2011-08-18 10:52:12	1	4	135	0	43	147	14	218.20	25	71.31	CHANGED	pclpVcYhFpNsosp-lph.luFPh......P.............................h.hs.....s........sspshlpsF+lhVsG+.lpsph...........p.hs.................t.-lostLtppG..........h...t..h..........t...............tthh-tst..t.tashphhY.hWppsFsAGcsV.lcHsYpPs......lusul.......................t...tthChp.t.htthtth.............t..ht.pplsYVLoTuusWp.tsIt-FpLplc+sssspllshCa...ssl+Klssp........................................papappcNFsPpcD	..................clpVcYhFpN.osp-lp..luFPh......P.............................h..s..............sptshlpsFchhlsG+.ltsphp.hs....................................-lostlhttG.........................h...t.............t............thhctst....thshp.ha.hWppsF.supsl.lcHsYpPs......sutul.........................t...t..C.t.t..t.h.th................hh.pplsYlLsTussWt.tsItcFpLplctts.pt..llshCh...tsl++lssp.....................................phphppcsFhPpcD........................................................	0	15	27	31
+14263	PF14416	PMR5N		PMR5 N terminal Domain	Anantharaman V	la_psag	Manual	Domain	The plant family with PMR5, ESK1, TBL3 etc have a N-terminal   C rich predicted sugar binding domain followed by the PC-Esterase (acyl esterase) domain [1].	29.20	29.20	29.20	30.30	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.22	0.72	-3.92	63	964	2011-08-19 17:52:04	2011-08-19 18:52:04	1	11	31	0	619	937	0	55.20	41	12.91	CHANGED	sppCDlhpGcWVhDsst..P......LYpspsCs..alppthsCtcsGRPDpsYhp.WRWpPcsCs	...............s.tpCDla..p.GcWVh....Dss......t.....P........LYs.s.p.sCs..alppphsChpsGRPD.p.s.Yh+.WRWpPpsCs.......	0	64	359	499
+14264	PF14417	MEDS		MEDS: MEthanogen/methylotroph, DcmR Sensory domain	Anantharaman V	la_psag	Manual	Domain	MEDS is prototyped by DcmR and is likely to function with the PocR domain in certain organisms in sensing hydrocarbon derivatives [1][2] The MEDS domain occurs fused to Histidine Kinase and as standalone version [2]. Sequence analysis shows that it is a catalytically  inactive version of the P-loop NTPase domain of the RecA superfamily [3].	28.70	28.70	29.50	28.70	28.00	27.80	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.09	0.71	-5.24	30	260	2012-10-05 12:31:09	2011-08-24 23:25:56	1	51	146	0	138	283	15	172.90	20	39.54	CHANGED	hctthRpSGl-llG.-lPaGTHhCQFYpTcE-Lh-lllPYhKuGLEsNEhChWlsop..P.plE-AKpuL+cslP-l...-hYL-+GQl-Ilsh..hh...hp-ushDspRllsshlcK.hscAlt.....pGYcGLRlsGsshWhtKp..-asshssYEpclDuslssp...phhuLCsYsl-chsus-llDllssHpFsLlK+ct+Wpp	.......................................................h......................sH.shhYp.sp.p-hhshhssFlppGLts.sE.....shhhss...stpht.lp.ptL....................hh.ssup.l.plh...s...h...............spushss..schlsthtph...hspuht......tGhpslRlhG-.hs.Ws..tcs....sphs.thh.paE.shlNphh.sst...shh.hL.CsYDt.......pphssp...s....lt-shtsHshhh.........t........................	0	61	101	117
+14265	PF14418	OHA		OST-HTH Associated domain	Anantharaman V	la_psag	Manual	Domain	OHA occurs with OST-HTH [1]. 	25.00	25.00	25.40	26.60	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.28	0.72	-4.48	28	75	2011-08-27 06:30:04	2011-08-27 07:30:04	1	8	27	0	69	81	0	74.20	23	9.32	CHANGED	...tps.hhFs..GGRYuhActL+cps..th+shoLGpls+lVQlAlp.ppllh.Ypps.sLhP...hpssppsssshhstssppp	..............s.......hs..sGRYshAcpL+cps..hh+shsLGclhclVpluls.c+hhh.Ypss.tlhP...hptstthspshhs.....s................	0	29	45	59
+14266	PF14419	SPOUT_MTase_2	SPOUT_MTase_11;	AF2226-like SPOUT RNA Methylase fused to THUMP	Anantharaman V	la_psag	Manual	Family	SPOUT superfamily RNA methylase fused to RNA binding THUMP domain [1].	28.40	28.40	28.60	28.40	27.80	27.60	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-10.93	0.71	-5.08	28	37	2012-10-01 22:53:19	2011-09-01 23:30:29	1	1	37	0	31	42	0	175.20	55	49.03	CHANGED	KlslVQMPYhGDhcus+phGE+IGRAAQuFEVKELIIAP+cplsAaELhpFl+GV+cGQcSRYpIQ++uYshcVc+VPVhVhDLYQllRDK+R.pscllIlTDPKGcplocVK-+Lucsh.....+tu+EVllFlGSREGIPpGlFRFADaVlDLAPahTFATEauIPusLlALholYEEtt	........................KlslVQMPYhGDhcusRphGE+IGRAAQuFEVKELIIAP+cphsAaELhpFl+GV+cGQESRYpIQ+cuYshcVcKVPVhVaDLYQllRDK+R.ppcllIlTDPKGcplscVK-+LAcsh.....+hu+EVllhlGS.REGIPp.....Gl..FRFADaVlDLAPa...hTFATEauIPusLlALholYEEth.....................	0	11	15	21
+14267	PF14420	Clr5		Clr5 domain	Bateman A, Wood V	agb	Wood V	Domain	This domain is found at the N-terminus of the Clr5 protein which has been shown to be involved in silencing in fission yeast. This domain has been found to often be associated with proteins that contain ankyrin repeats and large regions of disordered sequence [1].	22.30	22.30	22.30	22.40	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.67	0.72	-4.07	93	327	2011-09-06 09:24:57	2011-09-06 10:24:57	1	30	74	0	281	320	0	54.30	29	10.23	CHANGED	tspcW-th+shIpcLYh......pcphsLc-VhchM.....cpcasFpA....o...................c+tYcp+hc.cW..GhpK	............spsW.-sh+shItcLYh......pcphsL...c-VhchM.....cppasFps....o...................................................................p+tappphc.cW..shtK................................................................	0	54	142	232
+14268	PF14421	LmjF365940-deam	CDD_CDA_1;	A distinct subfamily of CDD/CDA-like deaminases	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A distinct branch of the CDD/CDA-like deaminases prototyped by  Leishmania LmjF36.5940. Members of this family are widely distributed across several microbial eukaryotes such as kinetoplastids,  chlorophyte algae, stramenopiles and the alveolate Perkinsus. Domain  architectures suggest that these proteins might possess mRNA editing  or DNA mutagenizing activity [1].	45.70	45.70	134.30	59.00	32.40	23.90	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.63	0.71	-4.92	12	36	2012-10-02 00:10:39	2011-09-07 19:24:38	1	2	20	0	17	35	0	133.90	25	37.19	CHANGED	shhslhh-p.psahsphsshh.p....ppscs.Wh+Ks.p+PVlssLh..Vchc....sthst.sup.p................................hhhulNhElShPoGShCSEpNAlGp...............lAslul.........................................................................................................PTps....................................hRt.................................h.s............tst+ps.........................NPLaPCGsCpphL+Klsc.....hssshplhhF-ss.pscplhhhsls	...s.....hhp..t.....h............t..ah+ps..+.Vls.lh..h..................................................h..uhNhElShPoGShCuEpsshup.hs.........................................................................................................................................................................................................................................................................t...........................pP.h.shs.s.phL.+ltp......ss.hhlhhats..p..t.lh............	0	10	14	17
+14270	PF14423	Imm5		Immunity protein Imm5	Iyer LM, Zhang D, Aravind L.	la_psag	Manual	Family	A predicted Immunity protein, with an all-alpha fold, present in bacterial polymorphic toxin systems as an immediate neighbor of  the toxin [1] .	25.00	25.00	35.50	35.50	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.17	0.71	-4.67	12	38	2011-09-07 22:45:15	2011-09-07 23:45:15	1	3	23	0	12	41	0	171.10	29	58.91	CHANGED	ppIEK....Lpc.IspsuhGHLsLshRlcLM+pIsssph...........lpKlhhpCspKssuhascpFss-s.l.plLtchp..paLYpscGsh-pl.s.s-RhcsYlpps.-ps.-hssaslluL..GaAltsDAuolls.tDYsu.ED....DssaD.EuWssDFlsulAhSGu..PFs..-sGssE+R+cYWhWYlphslphsp	.......................................................lp+....hht.lttss.GcLsLshRhplhpthspsp...............lptlthhCsc+shshWscpFsssp.l.thLp...phL.pscus.......hcphts.ht+.p.asp.h.ppshshsthshhhl..uaAAssshs..osl.p..p...a..ss..cD.....Ds-hDPEua-ssalsu.AhuGGhsa....s-psssEtRRtaWhWYLs.sls...h....	1	3	10	11
+14271	PF14424	Toxin-deaminase	DEAM-TOXIN1;	The  BURPS668_1122 family of deaminases	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Burkholderia BURPS668_1122 [1]. Members of this family are found as toxins in polymorphic toxin systems in a wide range of bacteria and in the eukaryote Perkinsus. Members of this family typically possess a DxE catalytic motif in Helix-2 of the core fold instead of the more common C[H]xE motif.  The Perkinsus versions are predicted to be inactive [1].	29.60	29.60	31.20	31.20	27.30	28.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-11.09	0.71	-4.18	14	120	2012-10-02 00:10:39	2011-09-08 05:48:19	1	24	101	0	32	108	0	131.10	30	15.23	CHANGED	ptphscl+tshs............hchtNhulAchchph......stphhuhSt.spstt......t.............h..ps.....ssplhps....................tsssphh.....sRhsDoEhKlLcpltppltssshss.................GplslFoppssCpSCts.llppFptcaPpIphssh....s	.............................................................t....tph+.phst........thpp.uNhAlAch.pltuh......pphh.A.Sthsphpt......t.........................hs.ps.........ps.hFcs..t..................tpssh.h..................Rsh..DoEhKlLpsIAppLss..sppss..................Gp..IcLaTEhssCsSCs.........s.VItpFpp+Y.PNIplplh...t.................	0	5	25	26
+14272	PF14425	Imm3		Immunity protein Imm3	Iyer LM, Zhang D, Aravind L	la_psag	Manual 	Family	A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene [1] .	25.00	25.00	25.40	26.40	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.48	0.71	-4.13	26	52	2011-09-08 18:59:05	2011-09-08 19:59:05	1	2	39	0	8	34	0	116.30	55	95.29	CHANGED	McDWEYNELF-AIpEsYcEhL---R.Ga+YAIA+luDE.F...D...NL...GKIEDVIVDTAIGEIslsHc.+VFlGhIcGITKRLShFN.pEAp.....sELThEEI+DLopRINpVlEGLcNVclDYpPSs	..................MKDWEYNELF-AIpEsYcElL-E-R..GY+YAIAKLuDE.F..D...NL...GKI..EDVIVDTAIGEIulsHc.KVFlGhI-GIT+RLSpFNsQEAt.....sELTlEEIKDLSpRINKVIEGLKNVclDYsPSs..............	0	4	6	6
+14273	PF14426	Imm2		Immunity protein Imm2	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A predicted Immunity protein, with a mostly all-alpha fold, present  in bacterial polymorphic toxin systems as an immediate gene neighbor  of the toxin gene [1].	35.70	35.70	39.80	39.60	35.20	34.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.72	0.72	-3.97	5	9	2011-09-08 21:17:19	2011-09-08 22:17:19	1	1	9	0	1	7	0	59.30	46	73.66	CHANGED	MLEVlsLILSAGRuPD+V-haHpctI+cLLpEIsLssLLcDlPuDEAuELRcDLRlLKLl	MhsVIhhILSGGhaPDh.-.hh+ctIhchlhsIsLssLLpslPuEEAE.hRaDLRlLKhl.	0	0	0	1
+14274	PF14427	Pput2613-deam	Pput2613-DEAM;	Pput_2613-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Pseudomonas Pput_2613 [1]. Members of this family are predicted to function as toxins in bacterial polymorphic toxin  systems  [1].	25.00	25.00	28.40	54.70	22.70	17.50	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.47	0.71	-4.42	4	6	2012-10-02 00:10:39	2011-09-08 22:47:24	1	5	5	0	2	7	1	116.50	34	4.32	CHANGED	pF.uSu+Gs.HpAhsslpDssGplpspuhhh.SGNMTpsEttLGFPcsSLATHTEuRhs+pls.pp....GDhhlI-GpYsPCspCKGtMphtupcoGAclpYpWspsst..schWpsGph+cp+	....F.uSu+Gs.HsAshslaDssGslpspuslh..SGsMTcsE+pLGFPcsoLATHTEuRhl+cls.ss....GDhhlI-GpYPPCs....uC+GtMpttupcoGupIpYpW.psts..scpWpttp.pp.p........	0	1	1	1
+14275	PF14428	SCP1201-deam	SCP1201-DEAM;	SCP1.201-like deaminase	Iyer LM, Zhang D, Aravind, L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Streptomyces SCP1.201 [1]. Members of this family are predicted to function as toxins in bacterial polymorphic toxin  systems [1].	25.00	25.00	36.00	35.40	22.00	21.50	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-11.00	0.71	-4.46	25	44	2012-10-02 00:10:39	2011-09-08 23:43:07	1	10	31	0	24	53	0	131.40	25	15.12	CHANGED	spphsPshsssthtth..............sthTpGplFctsGp....lsshh..Su..ccp.tpthhshhtspu.........s.hshssHVEsKhAhhMpc.......suhccuslsIN..ssPCst............CcphlPtlLPcGSoLpVahst......sstlcGtu.t	...............................sP.hhsshh.th..h..........ts.hTpGplaptss.t...hsshh...Su....pcp.hptlhphhtshs.........s.hshssHVEsKhAhhMpc.........suhcpuslhIN..ssPCss.........t....CcphlshlLscGupLpVhhst......thhhtuh..h................	0	11	21	23
+14276	PF14429	DOCK-C2		C2 domain in Dock180 and Zizimin proteins	Zhang D, Aravind L	la_psag	Mannual	Family	The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated  cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the  Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain [1][2].	25.30	25.30	25.70	27.50	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-11.24	0.71	-4.65	45	1118	2012-10-10 12:23:49	2011-09-09 02:18:47	1	34	216	2	631	942	4	187.60	30	10.24	CHANGED	h.ssapNpLalthpphshs.....Kpsp.............t+Nlhlslplpsscsp.......pshpsIastsss.....phpsphtoslha+scpspat-plKlpLPhplspptHLhFohhcsssp......psppt....p.huaualPLhc..sGph.............lpssphsL.lh..............tp..ttYhphs.t....................hhcss+shhplpsplsSohhspsssl	............................sshRNcLYlh.pphcas............+ttp............................spsRNlpVplphhsu-sp......................phhpsI..astuus.............htsph.ho.s.....V.haHs.p.s...........Pc.ah-plK..lpl....P.....hph........hpp.......p.HLhFoFhHhSsp.......................pppcpt............Ep.hGau..alPLhp...c.Gp................................lpsup..apLsV................ttp.sssY.L.sl.ssst.tht........................................................................shphscu.sKssFplpohlsSThhTQsspl....................................................................	0	183	251	418
+14277	PF14430	Imm1		Immunity protein Imm1	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A predicted immunity protein, with an alpha+beta fold and a conserved C-terminal tryptophan residue. The protein is present in a wide range of bacteria in polymorphic toxin systems as an immediate gene  neighbor of the toxin gene [1].	25.70	25.70	25.80	26.20	25.00	25.30	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.51	0.71	-3.98	26	58	2011-09-09 15:11:35	2011-09-09 16:11:35	1	1	41	0	26	66	2	125.30	16	90.44	CHANGED	lpshhstt.......pssshhlso.s-l....-tllcchsthshs.....hsplhhs.s-...st....hshlssGl...s.sshuh.hhhhs....ss.s..sthhstssss.......tt..hhashssssp-..a..Ps....sppls....l-ssppAstpFhpsG.p+PsslsWppt	.........................................................h................tt.h.hts.tpl....pthlpth.tt.t.............hhplhhs.ss....s.........shlssul...p..sphuh..lhhhs.........ss.s....tthhssssss.....stt......hp...hsssss-.....a..Ps....sstlsl-psppAlp-Fhp..ou..p+PsslpWp..h...	0	7	19	25
+14279	PF14431	YwqJ-deaminase		YwqJ-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Bacillus YwqJ [1]. Members of this family are present in a wide phyletic range of bacteria and a few basidiomycetes. Bacterial versions are predicted to function as toxins in bacterial  polymorphic toxin systems [1].	25.90	25.90	25.90	28.00	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.56	0.71	-10.86	0.71	-4.27	14	91	2012-10-02 00:10:39	2011-09-09 18:36:12	1	16	76	0	42	98	2	125.80	27	22.31	CHANGED	hshhtspshstpchs.sshuuslchp......sGchhpuhstttp.............sslHPhlpshlsph...............pthpp.a..........tsGppAEltulsptLhp..........................tstchhshthpth.....hshtpGthh.sCssCshllpphsh	...................................ttp...........th..sssAuulshc..Gp.....hhputuspss............sssLHPhlpchLDshss.........................sppcp.a...............sGpCAEshhluctLtsh-tt...............t.tttshp.tu+lpstplRps.....scshcG.....s..htsPCcsCsslhsphs.........	0	8	31	38
+14280	PF14432	DYW_deaminase	DYW_Deaminase;	DYW family of nucleic acid deaminases	Iyer LM, Zhang D, Aravind, L	la_psag	Manual	Family	A family of nucleic acid  deaminases prototyped by the plant PPR DYW proteins that are implicated in chloroplast and mitochondrial RNA transcript maturation by numerous C to U editing events [1]. The  name derives from the DYW motif present at the C-terminus of the  classical plant PPR DYW deaminases. Members of this family are  present in bacteria, plants, Naegleria, and fungi [2]. Plants and  Naegleria show lineage-specific expansions of this family. The  classical DYW family contain an additional C-terminal metal-binding  cluster composed of 2 histidines and a CxC motif and are often fused to PPR repeats. Ascomycete versions, which are independent lateral  transfers, contain a large insert within the domain and are often fused to ankyrin repeats. Bacterial versions are predicted to  function as toxins in polymorphic toxin systems [2].	25.60	25.60	25.70	25.60	25.50	25.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.90	0.71	-4.10	17	1779	2012-10-02 00:10:39	2011-09-09 19:11:19	1	778	129	0	1096	1827	0	121.80	40	20.51	CHANGED	sssshsps.....hphhuG.ts+...........phhpRh.ps.shh.spsp.hhH.slcspcpp...................hhhpHuEK.tlshuhhp.................hhhps.....................................................................................................................................+lCsDCashhphluphhsp-IhVpDs.sph+hFc	.................................................................................................................ht.hh.............HtFhssDp.sHPptppIh.......t.Lpclht.c.h..c.p.t..G..Y..h...P-op.h.V.La..Dl.-.-....E.pK..................................h.L.t...hHSEKLAlAFG...Llsossu.....................sslRlhKNL....................................................................................................................................RlCsDCHsuhKhIS+lh.sREIllRDs.sRFHHFc.........................................	0	111	754	916
+14281	PF14433	SUKH-3		SUKH-3 immunity protein	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems [1].	24.60	24.60	24.60	25.50	24.50	24.30	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.46	0.71	-4.41	35	175	2012-10-01 20:46:44	2011-09-09 19:50:34	1	3	133	0	43	157	2	134.00	22	81.79	CHANGED	spplhphLppuGWh.......tsRplshshhhpthtpt.....ua.lhssstp..FLpcFGsLplt.......................tppssstshphsPhhsh.....tpppphpphtph.....lssplhPlGpht...ssthhLhls....-sGplashtp...........thhhlGsshppulpsllpupt.t	................................................tl.thLptuGWh.......psc..p..h..s...hsh......hhcthtpt..........tatl..hs..ushc..hhpcaGuLpht..t....................tpphsstshthcPhpsh.............h.tpphtphtpt.....ls.pplhPlGptt.....psphhlhls....ppGclYuh.cs.............h.hhhGsshppulppLltut..t.......................	0	11	30	39
+14282	PF14434	Imm6		Immunity protein Imm6	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A predicted immunity protein, with an alpha+beta fold (mostly alpha  helices). The protein is present in polymorphic toxin systems as an  immediate gene neighbor of the toxin gene [1].	25.00	25.00	30.70	30.60	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.36	0.71	-4.41	29	64	2011-09-09 19:11:10	2011-09-09 20:11:10	1	1	38	0	18	54	0	119.00	28	74.73	CHANGED	hspstahLsluptlhshl.cppp.p...........ph..ccuL-tCW...pal-s.cphsuDpLYshL-s.pD.pslhhahp..pc.ccpp.shWssIhsAluhsuhhA.YphEscca.lPpslEslD.-ppl-hahpphpchh	.................h..hstahLtlu-tlhshlppppht...........phh.ccuL-tCa...pal-s.cphsuDpLYshL-s.tD...pslhhahp..p-.ccpt.shWssIhpuluhsuh.A.Yph-sc+a.lPpslEslD.pphlchahpshpch..................	0	5	7	10
+14283	PF14435	SUKH-4		SUKH-4 immunity protein	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	This family belongs to the SUKH superfamily and functions as immunity proteins in bacterial toxin systems [1].	25.50	25.50	25.50	25.50	25.20	24.40	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.03	0.71	-4.56	32	180	2012-10-01 20:46:44	2011-09-09 20:14:07	1	4	115	0	50	183	1	163.60	18	61.38	CHANGED	stppltphasttt...............lhphpptsh.....sthhp.pspcFLppsGlPpss......hhhhtss................hstlsph.h..........................stthtpahhlGpss....ts.lslct.soGpVhhlssss.......phhhlNoslspFspslhhhtphhtthtt.tt...................................tpp.pshstphppplptlDstAht.........stsaWstlhppl	.......................................................................t.........s.t................lhph.ttth.....t..h...stphL....sGlP.p.......hh.hts.................h..htph...........................stphtpahhlGpsh.........ss.lslp....ssuplhh.ls.ps..............p.hhlNoslspFspslhhhtchhpthhths.....................................tpt.tphhtp..hp...p.....plttlDsssht..........tsaWs.hhpp.............................................	0	11	35	48
+14284	PF14436	EndoU_bacteria		Bacterial EndoU nuclease	Zhang D, Iyer LM, Aravind L	la_psag	Manual	Family	This is a bacterial verion of EndoU nuclease. It is found at C-terminal region of polymorphic toxin proteins. 	25.50	25.50	25.70	25.70	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.70	0.71	-4.30	57	308	2011-09-09 20:44:37	2011-09-09 21:44:37	1	33	244	0	65	277	3	120.20	21	21.59	CHANGED	sspshpHlhpG-hspt........thsGhHttsth..................sp.l.p.ht.........ss.pGlhpsphph.t.stt.............tstoohFPpp..WospclhstlppAhpspptpt.................ssphtutsss..............Glplc.shhpsp....GplhosaPhh	..................................................................s.....tHh.tsp..t..........h.GhHt.s.....................ht.lhttht..........pGlhphphph.t.stt...................tstpohFPcs..WocpcIhptlppAhpstthht.................sphhtstsps..............Gl+lc.shhcst....GplhohaP.....................	0	13	31	47
+14285	PF14437	MafB19-deam		MafB19-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Neisseria MafB19 [1]. Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems [1].	28.90	28.90	29.00	28.90	28.80	28.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.99	0.71	-4.56	20	53	2012-10-02 00:10:39	2011-09-09 23:23:34	1	17	53	0	8	55	3	145.10	37	12.83	CHANGED	hsshsphtshp.tlG.shstt...............tsshsslApscIsGppFhssNpsu+s...lus....spsshhssplthp.t.........spsshsssHAElsslQQAa-t..Ghsh.GpshshhVs.+-lCshCp....uslsshAcchGLcpLslaspt..oG..pshhasss	...........................................h...................................psp.pVlAcusIsG..cpFhDsNQoA+....lus..sspPTLhutplphchp.....t..tPN.sshusuHAEIulIQQAYsA..GhTt.GtsMshhVsGK-VCuaCp....GslsuhAcpoGLcpLslpsss..oG..pohYap..................	0	3	3	4
+14286	PF14438	SM-ATX		Ataxin 2 SM domain	Anantharaman V, Eberhardt R	la_psag	Manual	Domain	This SM domain is found in Ataxin-2 [1].	28.40	28.40	28.40	28.40	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.49	0.72	-4.05	52	367	2012-10-01 22:42:21	2011-09-11 08:17:31	1	11	227	28	216	462	1	75.30	29	8.85	CHANGED	cRhhahhssllGppVpVplpsGsh.YcGlhpohssp...........phsllL.chs+hlsss.t..........ppstspphhcslllpspDllp	...........RhlahlssllGppscVp.l+.sGsh.YcGlF+ohos............chslsL.chs+chsspss.............ssspppsls-ohlhpssDls......................................	0	66	108	163
+14287	PF14439	Bd3614-deam		Bd3614-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Bdellovibrio Bd3614 [1]. They are typified by a  distinct N-terminal globular domain. The Bdellovibrio version occurs in a predicted operon with a 23S rRNA G2445-modifying  methylase suggesting that it might be involved in RNA editing [1].	38.50	38.50	39.20	130.90	37.70	37.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.65	0.71	-4.31	4	4	2012-10-02 00:10:39	2011-09-11 22:36:34	1	1	4	0	4	4	0	124.00	36	37.69	CHANGED	pshacRDRcVsAhLlssp.GtlhssAsNoNucNtsLHAEhNLLhPhhhtp.......................t+sl.sGspLhVTLQCC+MCAAhlsthu-t.ut...hcVsYhpEDsGuLARcTtLcp+GhEp+hst	.pshacRDRcVsAhLlssp.GtlhssAsNoNucNtsLHAEhNLLhPhhhtp.......................t+sl.sGspLhVTLQCC+MCAAhlsthu-t.ut...hcVsYhpEDsGuLARcTtLcp+GhEp+hs..	0	2	3	4
+14288	PF14440	XOO_2897-deam		Xanthomonas XOO_2897-like deaminase	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Xanthomonas XOO_2897 [1]. Members of this family are present in a wide phyletic range of bacteria and are predicted to function as toxins in bacterial polymorphic toxin systems [1]. The Xanthomonas XOO_2897 lack an immunity protein and is predicted  to be deployed against its eukaryotic host [1].	32.60	32.60	33.40	36.00	31.40	31.40	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.97	0.71	-4.39	16	52	2012-10-02 00:10:39	2011-09-11 23:02:42	1	9	41	0	20	57	0	113.50	36	17.59	CHANGED	h.s.sshshsG.......sptsshhtpss................pphlhtp........................................tssHuEcpllpplpp....tsltPsplhclYoEhpPCst.t....Ctphlcs.h.ssscloaohs..aGt-ttst...hppuhspLhp	...................................................................s......s.hG.......s..sshhhps...............t.tp.hhtpu.t...................................ssssHsEhphhppLcs.......hsVsPppVlELaTELEsCchPGsh....Cuchl+cpa.PpsRlopsss..YGsDpsu...RppGhppLl.t..........	0	5	14	19
+14289	PF14441	OTT_1508_deam		OTT_1508-like deaminase	Iyer LM, Zhang D, Aravind L, Eberhardt R	la_psag	Manual	Family	A member of the nucleic acid/nucleotide deaminase superfamily  prototyped by Orientia OTT_1508 [1]. Members of this family are present in a wide phyletic range of bacteria,including several intracellular parasites and eukaryotes such as fungi, Leishmania,  Selaginella, and some apicomplexa. In bacteria, these deaminases are predicted to function as toxins in bacterial polymorphic toxin  systems [1]. Versions in intracellular bacteria lack immunity proteins and are likely to be deployed against their eukaryotic hosts. Eukaryotic versions are predicted to function as nucleic acid (either DNA or RNA) deaminases. Among eukaryotes, some fungi show  lineage-specific expansions of this family. Many fungal versions are  fused to a distinct N-terminal globular domain. Various fungal  versions are fused to domains involved in chromatin function.  Apicomplexan versions are fused to tRNA guanine transglycosylase  domain [1]. 	25.00	25.00	25.10	25.40	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.54	0.71	-4.39	23	207	2012-10-02 00:10:39	2011-09-11 23:54:14	1	6	86	0	171	219	0	165.50	15	29.16	CHANGED	htttthphtshph.sht.....................phts.thhtthptpt...tt.......................pshhhthppp..............................................t.psplHAEhhllcplppp...................st..YlG....sSKhsCssCphhlpths.............ttpsshhts....cspsa.tW.phss...............tpspthpphh	..........................................................................................................................hh.t..................................................................................................h........t.......................................................phpstlHAElpllpahtppt.............................hhss.pYIG.sSK.uChhCphahpths...............phhhhts.....HsplY..pW.phPs......................ht.h..........................................	0	35	93	140
+14290	PF14442	Bd3614_N	Bd3614-N;	Bd3614-like deaminase N-terminal	Iyer LM, Zhang D, Aravind L	la_psag	Manual	Family	This is a globular domain that occurs N-terminal to the Bd3614-like deaminases, which are predicted to be involved in RNA editing [1].	25.00	25.00	65.00	63.60	22.10	21.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.75	0.71	-4.20	4	5	2011-09-12 09:35:36	2011-09-12 10:35:36	1	2	5	0	5	5	0	126.80	35	37.92	CHANGED	puSscccDVAFLlAsssu-...u-AcssVaaApussssss.cSAlV+LlLG..........AppuusRspusuW..hRtRIhTT.tulSshDRAhVKVsApRsTth......slcscDcuAsA......st.sssDDscs........LphhDsTshAptAlpRGh.s	...puSscccDVAFLlAsssu-...u-AcssVaaApussssss.cSAlV+LlLG..........ApEuuGRspucuW..hRpRIaTT.+ALSshDRAlVKVsApRATsl......clcsDDDuAsA......st.sssDDDDDDDAs......LEhcDlT-aARtAlcRGAp.s	0	3	4	5
+14291	PF14443	DBC1		DBC1	Anantharaman V	la_psag	Manual	Domain	DBC1 and it homologs from diverse eukaryotes are a catalytically  inactive version of the Nudix hydrolase (MutT) domain [1]. DBC1 is predicted to bind NAD metabolites and regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction [1].	25.00	25.00	26.30	26.40	22.70	21.50	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.61	0.71	-4.62	13	186	2012-10-02 00:00:35	2011-09-12 21:55:47	1	8	89	0	108	182	0	122.50	51	12.57	CHANGED	.sHPs+llKFLVGp+sK.EsMAIGGpWSPSLDGsDPpsDPpVLI+TAIRssKAhTGIDLSsCTpWYRFsEl+YhRstppt.....sss+lETVVlFLPDVWshlPTcp-WcsLptshpppLscphptspppss	............pHPs+hlKFLV.G..hKu+..E..........sMAIGGpWSPSLDG..sDPppD.PsVLI+TAIRssKALTGIDL..SsCT.............pWa...RFAEl..........+YhR.stppt.............................sPs+lETVVlFhP..DlWphhPohpEW-slppthppphs.cphpt.....s.....................	0	32	49	73
+14292	PF14444	S1-like		S1-like	Anantharaman V	la_psag	Manual	Domain	S1-like RNA binding domain found in DBC1 [1]	25.20	25.20	25.70	25.30	25.00	24.90	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.61	0.72	-4.24	11	185	2012-10-03 20:18:03	2011-09-12 22:52:37	1	6	68	0	90	173	0	56.30	57	7.05	CHANGED	QRVF..TGh..VTKlp-sFGFlD--VFFQhSs.VKGthPpVGDRVLV-AuYNssMPFKWNAsR	......QRVF..TGlVT+L..H.DsFGhVDE-VFFQl.........Ss.VK...G+.hP.p.VG-+VLVcAsYNPs...sh.WNA.+..............	0	18	26	48
+14293	PF14445	Prok-RING_2		Prokaryotic RING finger family 2	Burroughs AM, Iyer LM, Aravind L	la_psag	Manual	Family	RING finger family found sporadically in bacteria and archaea, and  associated with other components of the ubiquitin-based signaling  and degradation system, including ubiquitin and the E1 and E2  proteins. The bacterial versions contain transmembrane helices [1].	22.10	22.10	23.00	91.00	21.20	21.90	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.31	0.72	-4.02	2	3	2012-10-03 15:03:13	2011-09-16 18:03:25	1	1	3	0	2	3	0	57.00	53	61.96	CHANGED	DPcSFupasCDLCpoutslutLRQCVlCGRWuCsuCWpDEYYhC+SCuGlhplh.Lc	DPcSFSRYoCDLCNooaPlu-LRQCVLCGRWACuSCWpDEYYsCKSCuGIIsLHLLc..	0	1	2	2
+14294	PF14446	Prok-RING_1		Prokaryotic RING finger family 1	Burroughs AM, Iyer LM, Aravind L	la_psag	Manual	Family	RING finger family found sporadically in bacteria and archaea, and  associated in gene neighborhoods with other components of the  ubiquitin-based signaling and degradation system, including  ubiquitin, the E1 and E2 proteins and the JAB-like metallopeptidase.  The bacterial versions contain transmembrane helices [1].	29.10	29.10	29.10	29.30	29.00	28.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.56	0.72	-4.23	14	24	2012-10-03 15:03:13	2011-09-16 19:23:01	1	3	21	0	11	26	7	52.80	34	12.45	CHANGED	.phpsstCssCGcpht.p-DlVVCPcCGAPYHRpCapchGpChphs.pssshshp.	......phpsspCshCGcphh.p-DlVlCspCGAPYHRpCapchGpChh.s.pttshph.h......	0	7	8	11
+14295	PF14447	Prok-RING_4		Prokaryotic RING finger family 4	Burroughs AM, Iyer LM, Aravind L	la_psag	Manual	Family	RING finger family domain found sporadically in bacteria. The finger is fused to an N-terminal alpha-helical domain, ROT/Trove-like repeats and a C-terminal TerD domain [1]. The architecture suggests a possible role in an RNA-processing complex [1].	27.00	27.00	27.00	27.60	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-9.18	0.72	-4.42	10	46	2012-10-03 15:03:13	2011-09-16 19:42:08	1	2	46	0	15	52	1	54.70	37	7.14	CHANGED	hhhQpP-QPClhCutsuos+slsPCuHlVCcsCFDGscYSuCPlCts+l-sucPF	...................h.p..hshlhshhsspp.sshLsCGHl.I.PcsTFPh..-RYN...GCPFCGsPF-sus...........	0	10	12	14
+14296	PF14448	Nuc_N	NUC_N;	Nuclease N terminal	Zhang D, Iyer LM, Aravind L, Eberhardt R	la_psag	Zhang D, Iyer LM, Aravind L	Family	This is a conserved short region that is found in many bacterial polymorphic toxin proteins [1]. It is often located before C-terminal nuclease domains [1].	25.00	25.00	27.70	26.20	18.80	17.30	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-8.92	0.72	-4.42	2	47	2011-09-16 20:53:49	2011-09-16 21:53:49	1	7	29	0	1	42	0	54.40	79	19.80	CHANGED	hDpsoshh+G..ElL.DGSVhR.uGTNaStphpEAHDuSKASIQSRISNLESGGVKGTtc	....hDoVoshhKG.VEIhPDGSVsR.oGTNYSGKFQEAHDASKASIQSRISNLESGGVKGTG..............	0	0	0	1
+14297	PF14449	PT-TG		Pre-toxin TG	Zhang D, Iyer LM, Aravind L, Eberhardt R	la_psag	Zhang D, Iyer LM, Aravind L	Family	PT-TG is a conserved region found in many bacterial toxin proteins. It could function as a linker that links N-terminal secretion-related domain and C-terminal toxin domain. It contains a TG motif [1]. 	23.50	23.50	23.50	23.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.43	0.72	-4.20	37	309	2011-09-16 21:38:00	2011-09-16 22:38:00	1	46	140	0	52	270	1	81.40	27	17.49	CHANGED	pppthshhh-hss..lushp-shcshpGpD..hTG-cl.shh-Rshuul.hh.uh.hs..huKlsphstth.thh....+uhcsstcsp	..............t.hchsh-hss.ElsGhhDhtRshsGhD.PsTGE+L.osh-Rl.h.Aushslhuh.hP.....hG+suphsp.sshths........+shtts....t............................................................	0	11	25	33
+14298	PF14450	FtsA		Cell division protein FtsA	Bateman A, Mian N, Griffiths-Jones SR, Anantharaman V	la_psag	Pfam-B_1177 (release 5.4)	Domain	FtsA is essential for bacterial cell division, and co-localises to  the septal ring with FtsZ. It has been suggested that the interaction of FtsA-FtsZ has arisen through coevolution in different bacterial strains [1].  The FtsA protein contains two structurally related  actin-like ATPase domains which are also structurally related to the ATPase domains of HSP70 (see PF00012). FtsA has a SHS2 domain  PF02491 inserted in to the RnaseH fold PF02491 [2].	31.80	31.80	31.80	31.80	31.70	31.70	hmmbuild  -o /dev/null --hand HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.43	0.71	-4.27	219	7122	2012-10-02 23:34:14	2011-09-17 14:26:47	1	10	3572	5	1490	4911	2477	177.60	22	77.84	CHANGED	lshlDlGuupsshslhct.....sshtt..........hpllslG.............ustlo..cclupul......ppslppAEcl...chphu..................ss..hh.........sthp.tppphp.lsh................t.spplsppclscllpsthp..........Ellchlspph........hpssh.ht...p.hssshVlTGus.utlpsl.tchspchh...............lcls..t....................hltsP........aA.ouhul	....................................sslDIGsupssshlhct..........t.t.tt...................hsllshG................ssh....ls........ccl......u......pul.............pp.s.h......p......p.A......Eph...ch.p.h.u.......................ss..hsslsupp.phtsspshsshsppthpppthphh.....................................................thh.ch.phhcp.hshtshch.stuhllTGusuhlpsl.hcsspcsh........................l+ls..p.............................hl.hp.P...husuhu................................................................................................................................................................................................................................................................................................	0	491	953	1235
+14299	PF14451	Ub-Mut7C		Mut7-C ubiquitin	Iyer LM, Burroughs AM, Aravind L, Eberhardt R	la_psag	Manual	Family	This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role [2].	23.00	23.00	23.00	23.20	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.45	0.72	-4.46	22	253	2012-10-03 10:59:06	2011-09-19 19:24:29	1	2	245	0	99	309	28	79.60	36	34.19	CHANGED	MssssFRFatELNsFLs.spRp+thupssscsATlKHhIEALGVPHTEVthlhVNGcssshs+hlp-GDRlsVYPphcshc	..............................lphRhasELscFls..h.t.t.R..t......t.s.ht.p.....sht.sssTlKcllEuLG..V..PHTEVsllL....VN....Gcsss...a....s....a....h....ht....sGD+luVaPhhcs.....................	0	31	68	89
+14301	PF14452	Multi_ubiq	Bac_multiUb;	Multiubiquitin	Iyer LM, Burroughs AM, Aravind L, Eberhardt R	la_psag	Manual	Family	A ubiquitin superfamily domain that is often present in multiple  tandem copies in the same polypeptide. Members of this family are associated in gene neighborhoods, or on occasions fused to, bacterial homologs of components of ubiquitin-dependent modification  system such as the E1, E2 and JAB metallopeptidase enzymes and a distinct metal-binding domain [1]. The E2/UBC fold domain appears to be  inactive. The JAB domain in these operons is usually fused to  the E1 domain [1].	24.50	24.50	25.20	24.70	23.70	23.50	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.29	0.72	-8.88	0.72	-4.00	24	160	2012-10-03 10:59:06	2011-09-19 22:07:54	1	7	84	0	69	158	3	72.20	21	64.51	CHANGED	pshphplsscphshscshloGpplhtlAthssss......phshhphh.ssppcslt.s-sV-LtppGhc+Flshpsc	.......hphtlsscphphscstloGpplhplAthssss......thsh.hphh....s.sptpplt.s-s.l-Lp....ppGhE+Flshp.............	0	22	43	59
+14302	PF14453	ThiS-like		ThiS-like ubiquitin 	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the ubiquitin superfamily that is often fused to the  ThiF-like (E1)- ubiquitin activating enzyme and is present in gene neighborhoods with components of the thiamine biosynthesis pathway [1].	26.00	26.00	28.30	27.10	25.60	24.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.46	0.72	-4.12	8	166	2012-10-03 10:59:06	2011-09-19 22:35:31	1	2	166	0	20	104	3	56.80	56	21.39	CHANGED	M+IhlNEcplsVc-ssoLatl+sphKs-ADVlIlNGFPlp-DhtLp-sDclhhI+RG	..................................MRlKFNGKELDTchpTSL-FFcslSKN..END..VW.IINGFATKENItLpENDELFCIE+N.	0	7	19	20
+14303	PF14454	Prok_Ub		Prokaryotic Ubiquitin	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A Ubiquitin-superfamily protein that is present across several  bacterial lineages, and found in gene neighborhoods with components of the ubiquitin modification system such as the E1, E2 and JAB  proteins, and a novel alpha-helical protein, which is predicted  to be enzymatic [1].	25.00	25.00	25.20	27.80	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.58	0.72	-8.88	0.72	-4.32	7	94	2012-10-03 10:59:06	2011-09-20 00:17:57	1	1	75	0	32	85	3	66.90	41	79.77	CHANGED	lphppLpRsFpa....NGhsLsDPsPpho.cpV+DFYSspYPELhsAsl-GPpscsshtpYoF++usGs	....hplpsLpRsFpa.....ss..l.p..LsD.P.ss.shSs-pVh-aYosp.YPELTTAsVcGPpl..cs-ptlYpF+pslGs.....	0	7	22	29
+14304	PF14455	Metal_CEHH		Predicted metal binding domain	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A predicted metal-binding domain that is found in gene-neighborhood associations with genes encoding components of the bacterial homologs of the ubiquitin modification pathway including the E1, E2, JAB  metallopeptidase and ubiquitin proteins. The domain is characterised  by a conserved motif with a CxxxxxEYHxxxxH signature.	25.00	25.00	95.30	30.90	22.90	22.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-10.97	0.71	-4.87	5	8	2011-09-20 03:51:40	2011-09-20 04:51:40	1	2	7	0	5	11	0	143.90	36	90.99	CHANGED	VDPAVSRAKFDR-IGpFcspAsAYRtQGCFLIEAsFPTAFFIFAsPKV+PplIGAAVEIDFoNYDLRPPSVVFVDPFTRpPlARKDLhLsMLRRPpLPGTPP-MISVLhQQpALSLsDFLQANSsEcTPFLCMAGVREYHDNPAHSGDsWLLHRGSGEGCLAFILDKIIKYGTGPVE	..............Vc.tlSRApF-RpluphpspssuaRhpGhhLlpApaPsh.hIFssspltP....htlclshsNaDhpPPSVshlDs.Tt.............ct.tLstsPPthhsshht..........pApssptpPFlCMtGsREYHspsuHoGD.W.haRGSG-hsLuhIL-pIh+hhpssl...........	0	1	3	4
+14305	PF14456	alpha-hel2		Alpha-helical domain 2	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	An alpha-helical domain found in gene neighborhoods encoding genes  containing bacterial homologs of components of the ubiquitin  modification pathway such as the E1, E2, Ub and JAB peptidase  proteins.	25.00	25.00	34.60	28.10	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-11.62	0.70	-5.66	11	36	2011-09-20 04:45:34	2011-09-20 05:45:34	1	2	31	0	19	34	1	298.60	19	85.51	CHANGED	lsslsLuhhctGshptu-l..s.ssss-hhtpslptWhcsphsshthhs.............t.sssss.hhppsssss.ps.hhhshshssp.lahl....csplpsLcuspPsLupslhsllpcuuups.htlhoPshhhshhuhhaWcucs...Dpcpshphhctps-..sEtthpthh.s.sh.................hhphhsthspphhph.pptphphhtppcshssplssAlscltshlpctp.c.p.s.hshssst.tp...........sltsushltWc-s-hspcllDDahEhttpuusuppt.shl.ls..ssspulpphhcshcthhphhtul-cLLshlup	............................................hhhhhhptsslp.sDl..s.ssstchhppuhptWhpcpsushphlphth.........ht.stsththhpsssc.ss.ps.lahshshsp...s.latl....tsplcsLcsspPsLutTslsllpcAuths.h.lhTP.shhhshhuhha.WcG-s...D--sshphhpcp.t-s..s.tphpthhsu.sh.......t.........hhphh.chhtpshph.t.pp...hphh..tpppshhtpl.....ss.....tlt.....plts.........h.lptsphp.....thhtsshpsp...........shh.hshlthpp.s........-hstcllDDah-hhspus.spsh.shl.ls..ssspultp.hpchptthphhptlDpLlshlu...........................	0	4	10	16
+14306	PF14457	Prok-E2_A		Prokaryotic E2 family A	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in several bacteria. The active site residues are very similar to the eukaryotic E2 proteins [1,2]. Members of this family are usually fused to E1 and JAB domains C-terminal to the E2 domain. The protein is usually in the gene neighborhood of a gene encoding a distinct metallobetalactamase family protein [1].	25.00	25.00	27.40	26.70	22.90	22.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.68	0.71	-4.78	12	50	2012-10-02 15:28:41	2011-09-20 18:18:15	1	5	48	0	22	55	8	146.50	22	21.40	CHANGED	ttchhtshhtptsstsht.htspttptshthphhVths.psshsstssssI+phEsl..hhhssshshphP.shhLRpDFPhp........sH.p.sh.sps......ss.Clh-ssh.....s-hhhphsh.....pullpplhhWLpcuApGsLhpsspshEPhhhsstss.hlhs.shthtttss	...................................h................ht..th.t..p.ht..t.h.phhl.hsspsthts.ssssl+phEpl.hlhhsss..hshssP.s.shRpDFPsp.......hPHlpss..st.......hplClacssh.....s-h.hshuh.....puhls+lhtWLpcAAtspLpp.ppshEshhh.s..t.lh..........s..........	0	9	16	20
+14309	PF14460	Prok-E2_D		Prokaryotic E2 family D	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in several  bacteria. Members of this family lack the conserved histidine  of the classical E2-fold. However, they have an absolutely conserved histidine carboxyl-terminal to the conserved cysteine [1,2]. Members  of this family are usually present in a conserved gene neighborhood  with genes encoding members of the Ub modification pathway such as  the E1, Ub and JAB proteins. These neighborhoods also contain a  gene encoding a rapidly diverging alpha-helical protein [1].	25.00	25.00	28.90	28.50	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.22	0.71	-4.80	17	151	2012-10-02 15:28:41	2011-09-20 19:31:56	1	1	122	0	43	142	4	171.90	23	72.96	CHANGED	shpshhphlctlspp.....hshssalss.ssLs......hussthhWWs...........PsspRtlaFcst........thtppstslPhPuLVFhsstp..........shhVaAl+ss.cPs.sTpLapsPaaNVappGplChGs..splP.ctssssphpsWcttFFsSt..............FTHPNstspphhht......shshapchh-sph.psFPpssLlshc	.............................................t..............t..........t.hh.s.shLh.........huspphlWas...........PstpRplaFtp..........hthtstpsshPsllatss.tp..........shpVaAl+s...s.cP.stsT.LapsPahNV.....h.s.p.GplChGs..sp..l..P...chp.s...hpt.lptWcphF.a.sSt..............Fo.H.ssspp............hhphhtphhct.t..psFstphLh...t.........................................	0	11	31	39
+14311	PF14459	Prok-E2_C		Prokaryotic E2 family C	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A divergent member of the E2/UBC superfamily of proteins found in  bacteria. Members of the family contain a conserved cysteine in place of the histidine of the classical E2/UBC proteins [1,2]. Members of this family are usually fused to an E1 domain at their C-terminus. The protein is usually in the gene neighborhood of a gene encoding a JAB peptidase and another encoding a predicted metal binding domain [1].	25.00	25.00	83.70	82.40	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.59	0.71	-4.07	4	5	2012-10-02 15:28:41	\N	1	1	5	0	3	5	0	129.40	59	25.17	CHANGED	AFDDQAASCAEGQATLDLAVRLLARLYPVLAILPLGSAAShQAQALERLAKSINPKlGIRRSGKS.AolClVAGsTRPsLRCPTFFhGSDGWAAKLSRTDPVGSGSSLLPYGAGAASCFGAANVFRTIFAAQ	.....AFDDQAASCAEGQATLDLAVRLLARLYPVLAILPLGSAAShQAQALERLAKSINPKIGIRRSGKS.ATlCVVAGsTRPsLR.CPTFFlGSDGWAAKLSRTDPVGSGSSLLPYGAGAASCFGAANVFRTIFAAQ..	0	0	2	3
+14312	PF14461	Prok-E2_B		Prokaryotic E2 family B	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in several  bacteria. The active site residues are  similar to the eukaryotic E2 proteins but lack the conserved asparagine [1,2]. Members of this family are usually fused to an E1 domain at the C-terminus. The protein is usually in the gene neighborhood of a gene encoding  a member of the pol-beta nucleotidyltransferase superfamily [1]. Many of the operons in this family are in ICE-like mobile elements and plasmids [1].	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.55	0.71	-10.60	0.71	-4.40	15	108	2012-10-02 15:28:41	2011-09-20 21:03:45	1	3	103	0	27	835	18	129.40	22	23.12	CHANGED	t.....h.pasps.sphhttsphsppssptshhtphhht.............pssshslpLVhscp.FshlPstlhls.-.pph...l.sHhts.s...GtLClh...ptsh-papssusst-ll.cphpplLp.pshsuss......ptchhuEasuYWptppssh........hh	..........................................................................thhhh.h..h...................................putshsltlsl.ss..a..t.h.P.th...h.lp...p.s..cphh.......hl.PHlph..s.....upLChhsp.psshs.sps....cush.t-s....h.cphpthLc..sulsusp............cs-htsEFtuYWptppp....h.....................................	0	7	18	21
+14313	PF14462	Prok-E2_E		Prokaryotic E2 family E	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	A member of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteristic catalytic residues of the E2 enzymes [1,2]. They are usually fused  to or in the neighborhood of a multi/poly ubiquitin domain protein. Other proteins of the ubiquitin modification pathway such as  the E1 and JAB proteins are also found in its gene neighborhood along with a distinct predicted metal-binding protein.	25.00	25.00	25.70	25.40	21.80	21.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.50	0.71	-4.53	5	36	2012-10-02 15:28:41	2011-09-20 22:59:24	1	4	35	0	15	40	1	123.80	31	52.33	CHANGED	LPEsDccYL-o+GaTaEsVsDGu++Glll+pFpLPpG+FssspVDlLllLPsGYPDssPDMFYlpPsL+LVsGs+hPpAo-sscpFpG+sWQRWSRH...NssWRsGlDGlaTMLKRVEcALcsAs	...................L.ptDppaLcshGhpa....Eslt-uutphll.lcsasLP.......pG..Y.....stsp.........s-lhlhlPs.uY.Psstl.DMFYspPsL.......phs..sGtt.......lP.s.....sp.sscshp...G+sWQRWSRH...pssWcP...shDslhTalthl-psLttth.........	0	4	8	11
+14314	PF14463	E1-N		E1 N-terminal domain	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	An uncharacterized alpha/beta domain fused to E1 proteins. This protein is usually present in gene neighborhoods with genes  encoding a JAB protein and a predicted metal-binding protein. In related E1 proteins, the E1-N domain is replaced by an E2/UBC superfamily domain [1].	25.00	25.00	46.30	45.70	24.60	21.70	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.87	0.71	-4.62	2	3	2011-09-21 18:21:18	2011-09-21 19:21:18	1	1	3	0	2	5	0	148.00	34	32.41	CHANGED	M.pssQpNAhMLAulLGssEs-AuERLsRsVLlTAsPGhtsuhhst.sthlh.RTVtVs.pp.sp-spLELVIG-sssRTsh.RlaAslsutGAssslcPVu+huG..PHsLhAAsAACssuAssl+hllDsssLPtsthPhRLDasQLGVP	M.pssQpNAhMLASlLGlsEsE.AuERLsRoVLlTAPPGsssA.thAp-VtALLuRTVsVVtpSsss-PsLELVIGDVsPRTS.usRLYAuluSsGATlulcPVuRsuGP.PHuLLAAlAACsVSAAVl+tVlDss-LPtVchPLRLDFDQLGVP.	0	1	1	1
+14315	PF14464	Prok-JAB		Prokaryotic homologs of the JAB domain	Iyer LM, Burroughs AM, Aravind L	la_psag	Manual	Family	These are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [1]. Prokaryotic JAB domains are predicted to  have a similar role in their cognates of the  ubiquitin modification pathway [2,3]. The domain is widely found in bacteria,  archaea and phages where they are present in several gene contexts  in addition to those that correspond to the prokaryotic cognates of the eukaryotic Ub pathway. Other contexts in which JAB domains are present include gene neighbor associations with ubiquitin fold  domains in cysteine and siderophore biosynthesis, and phage tail  morphogenesis, where they are shown or predicted to process the  associated ubiquitin [2,4]. A distinct family, the RadC-like JAB domains are widespread in bacteria and are predicted to function as nucleases [5]. In halophilic archaea the JAB domain shows strong  gene-neighborhood associations with a nucleotidyltransferase  suggesting a role in nucleotide metabolism [5].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.66	0.72	-4.46	111	2146	2012-10-10 14:49:21	2011-09-22 01:37:47	1	14	1332	8	470	3074	346	105.60	29	49.36	CHANGED	stphhptlhtpupps.....hPpEssGlllGpt.....................tpphhhhthh.......................................ssppphphht.................ttpppshphluhaHSHPssss...hPSppDtphstt..................shhllssh............th.........shphh	...............................................................................................................................hp...h.ptlhtp.upts.....hP.tEsCGhlhtp............................ptp.hh.h.s.hs...............................................................hcPpt.hhcht.................................hts-hps-lVulhHSHP..s.....uh.....s.....h.S...csD+ch.phpss............hsaallsps.....................ttpthtsh.....................................	0	149	304	409
+14316	PF14465	NFRKB_winged		NFRKB Winged Helix-like	Godzik A	adam	de novo domain prediction, confirmed by X-ray structure determination	Domain	This domain covers regions 370-495 of human nuclear factor related  to kappaB binding (NFRKB) protein.	22.20	22.20	22.20	28.60	21.30	20.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.45	0.72	-4.17	10	81	2011-09-23 07:25:46	2011-09-23 08:25:46	1	5	64	2	52	80	0	100.70	48	8.17	CHANGED	FFSLLRDllsSTspH..R..Lo..h..LcppLpsWp.ps...PsusLN-Wao.pss.D.WopLLpSAlpFLoG..-sss.hPs-FVPYlEaKsphs.YQWIGAuRDSD.ucLssLCphW	.......................FFSLLh-llhhcupso..Ls..h..LE-+VhcWQ.uS.....PASsLNsWaS.hsP.s.WucLVhsALpaLAG.........-sps....lP.S.....uFsPaV.EaK-csQpW+hlGt..upDs-.K-LuALhQlW...........	0	12	15	32
+14317	PF14466	DUF4425		Domain of unknown function (DUF4425) 	Godzik A	adam	BVU_3708 from Bacteroides vulgatus, JCSG target GS13500	Domain	A small family of bacterial proteins, found in several  Bacteroides species. Structure determination (NMR and Xray) shows an immunoglobulin beta barrel fold.\	Multiple homologs have been found  in human gut metagenomics data sets.	27.00	27.00	28.60	111.90	24.60	23.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.59	0.71	-3.98	7	32	2011-09-24 22:47:10	2011-09-24 23:47:10	1	1	30	5	3	26	0	119.80	39	79.95	CHANGED	tslslhhullhVSCus-Dspsss..psula+IslctSGc.cshthulhlssss.....sKlhsE.sGp.lupShss...chhss+hohpTstpsh.hTstGslhSppc..ustpLphhV..YhDGKEV.p.	.pslhlshuLlhluCsc--ppsss...+uGhY+IslpQSGshcSFcsSVslsuss....ss+Lhs-.sGc.lusuhSls..EhtosKsohsTstsuh.hTsuGulhStp-..uscpLplslhsYpDGKEVp+p.	0	1	3	3
+14318	PF14467	DUF4426		Domain of unknown function (DUF4426)	Godzik A	adam	Pseudomonas aeruginosa PA0388, JCSG target SP19004A	Domain	Members of this entry are found mostly  in g-proteobacteria, especially in Vibrio. Strangely enough, there seems to be one eukaryotic homolog in Nematostella vectensis (NEMVEDRAFT_v1g226006), where the PA0388-like domain is fused with a domain homogous to the Methionine biosynthesis protein MetW (see below). In several Pseudomonas species, but also in Vibrio vulnificus and Azotobacter vinelandii PA0388 homologs are genomic neighbors of Nucleoside 5-triphosphatase  RdgB (dHAPTP, dITP, XTP-specific) (EC 3.6.1.15) and Methionine  biosynthesis protein MetW. On the other hand, in most Vibrio  species it appears as a part of a conserved operon involved in possible response to stress.	25.00	25.00	79.60	79.40	19.90	17.80	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.33	0.71	-4.31	62	249	2011-09-24 22:49:33	2011-09-24 23:49:33	1	2	249	4	64	191	80	120.60	46	83.76	CHANGED	phcphG-h-VHYsuFsSTFLsPclApsYslpRSchpullNIoV.lcps...ttsp.suh..sAploGpspNLlGptppLsF+ElcEGs.AIYYlAphsasscEphpFpIslpsssp..stslcFpQchas-	....QhcsltDh-VHYsAFNSTFLTPcVApuYpLpRusYpullNISVLDpu..ph...up.sAs..pAploGpA+N.LlGphppLsF+cV+..EGs.AIYYLAEhPhss-EhlsFsIcVcsGsc.hstpLpFsQKFYs-...	0	13	28	48
+14319	PF14468	DUF4427		Protein of unknown function (DUF4427)	Godzik A	adam	PSYMP_19184 [Pseudomonas syringae pv. morsprunorum str. M302280PT]	Family	This domain is often found at the C-terminal of proteins with  Pfam:PF10899 domain, for instance in STY1911 protein from a  multiple drug resistant Salmonella enterica serovar Typhi CT18.	22.70	22.70	23.20	24.70	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.51	0.71	-4.43	3	112	2011-09-25 08:35:22	2011-09-25 09:35:22	1	2	109	0	2	45	0	125.80	91	33.30	CHANGED	LSuusVKsYsccIN-YIspLYSsKDahsDsYuhEFGNAWVWIHDNQs-VTRALLQcGhVSVN+EGRYLLKlsLtuScWPLR+KEshAKaVA+WL+pRFsLEuGYFSVhGu-DYDcIPaYNssLcENHPFYNs	.......LSASKVKNYADSINDYVSELYSKKDFLNDsYAMEFGNAWVWIHDNQSQVVRALLQAGMIKVNKEGRYLLDVNLASVDWPLRRKEAFASHVAGWLKHRFDIEAGRYSVpGKDcYDAIPSYETPLK-QHPFYNH.....	0	1	1	2
+14320	PF14469	AKAP28		28 kDa A-kinase anchor 	Jaroszewski L, Godzik A	adam	Q86UN6 A-kinase anchor protein 14 isoform a [Homo sapiens]	Family	28 kDa AKAP (AKAP28) is highly enriched in human airway axonemes.  The mRNA for AKAP28 is up-regulated as primary airway cells  differentiate and is specifically expressed in tissues containing  cilia and/or flagella [1]. Homologs of AKAP28 are present in all  animals and in some, including mice the AKAP28-like domain are  preceded by another uncharacterized domain 	21.60	21.60	22.10	22.00	20.20	21.00	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.51	0.71	-4.54	15	76	2011-09-26 09:21:28	2011-09-26 10:21:28	1	2	64	0	52	77	0	111.90	30	49.52	CHANGED	pWhTtGEFshpsulppI--FlspWpls...csWlass-.lp+--h.+uphYhhcV+aShPTtRpPlPpAoApVhFsIpVSKhcPtchPV.VoYhFEup+Lla.....Rssps.pFREpWL+cIlcoKhthh-	..............................hhoht-FphppuhppIccal.p.pWphp..........csW.latscalpccsh.puhhYhapV+aShPTsppPhPpsoAslaFhl.p.loKhcP.ph.Pl...lh......YhhEspphl+.....Rst.s...pFp-pWlcslhcsKh.hh.....................	0	22	24	36
+14321	PF14470	bPH_3		Bacterial PH domain	Bateman A	agb	Jackhmmer:C8LJ44	Domain	Proteins in this family are distantly related to PH domains.	23.00	16.00	23.00	16.40	22.90	15.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.14	0.72	-3.72	68	691	2012-10-04 00:02:25	2011-10-26 16:08:13	1	14	480	0	99	818	44	95.00	24	64.96	NEW	Lp..ssEplhhhs...hu...hh.p......................tpsshllsTs+Rllhhsp..phhtt.hp.h.pshsapcIsslphc..psl............hh.sc.lphts...sspplpl...p.l..s+sss.cphhphlpp	..............................................tE.h...h....hs....hhch..................h.sthpGhhlsTNc.R..Llhhth....sh.tp...hh...h....c..ph..s..ascIpsl.chc...................hs...pp..Ihhph...sttp..l.h...cpI..ppssV.phhlchlp............................................	1	34	63	82
+14322	PF14471	DUF4428		Domain of unknown function (DUF4428)	Bateman A	agb	Jackhmmer:C9XSR9	Domain	This putative zinc finger domain is found in uncharacterised bacterial proteins.	27.20	27.20	27.60	27.50	27.10	27.10	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.82	0.72	-4.22	24	71	2011-10-26 15:21:41	2011-10-26 16:21:41	1	8	57	0	10	70	4	49.50	28	20.98	NEW	pCslCspclGh..h...pt...hclpDG.h.lCcsChpKl....ssh.....h.pshph.p.hTlpcI+ch	..CslCspclGh..ht.....KlpDG.a.lCcsChpKl....psh.....h.tshp.h.pphTlpplpp............	0	6	9	9
+14323	PF14472	DUF4429		Domain of unknown function (DUF4429)	Bateman A	agb	Jackhmmer:Q9L067	Domain	This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and viruses, and is approximately 90 amino acids in length.  This domain is often found in two tandem copies.	25.00	0.00	25.10	5.60	23.80	-999999.99	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-10.17	0.72	-3.69	66	192	2011-10-26 15:23:52	2011-10-26 16:23:52	1	7	87	0	61	208	3	93.40	26	61.81	NEW	hsFDGpp.lplphs...htstth+pu...tG.spslslsslsuVpac.s.....sth....................................................tsGaL..Rhhhts....................ussstst.................ssppDPtsl...hhs.tcptthshhhsstVps	...............hsFDGcs.lplpap...hts.phptt..hG.-pplPlssluuVphc.P....sth....................................................tsGhL.Rhhh+s................................ussshtths...............ssspDPhsl...hhh.tcp.t.st.hsstl..t....................	0	19	48	59
+14324	PF14473	RD3		RD3 protein	Bateman A	agb	Jackhmmer:RD3_HUMAN	Family	RD3 is a human protein that is found preferentially expressed in the retina [1].  Mutations in RD3 causes Leber Congenital Amaurosis type 12 [2].	27.00	27.00	31.20	30.80	23.20	18.90	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.61	0.71	-4.68	17	73	2011-10-26 15:48:09	2011-10-26 16:48:09	1	1	43	0	55	70	0	130.30	43	66.10	NEW	hsWh.......p.hsp.s.ppsupRssp-.........lVscsLhhELphpl+ctE+.ppE+EpEtR+tc....otsDYSWLhoss...+tphplsssE+hpLEsLCu+lpPspsu.lIsRFRcllspp-spspElsplF+sVLp-hLpphccptp	..............sWh.......+.hspss..+.opRssuE.........hVh-TLMhELshpl+EsER.pcERcsEhR+hc.....TGVDYSWLsSsP...+ssaslossE+LQLE-lCuKlpPspCGslI.RFRpllAEp-P-spEVsplF+uVLp-sLcphcpEp......	0	7	15	33
+14325	PF14474	RTC4		RTC4-like domain	Bateman A	agb	Jackhmmer:Q59X99	Domain	This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres [1]. This domain is also found in proteins that contain a DNA-binding myb domain.	21.80	21.80	24.40	23.40	20.90	20.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.65	0.71	-4.18	38	169	2011-10-27 11:39:00	2011-10-27 12:39:00	1	4	127	0	125	175	1	120.40	28	26.24	NEW	ILsspp....sShY.............+shhcsphps.u+cpshphs...............t.thpphssGYYG.+Gtph.......hsptlhs+.auscLc+hAspsp........llpthGsssFsQtVLVPElhlhLltEDM......sls.......s.cc....................ARpIhc-Ss-hGshls-p	...........................................h..t...sShYhshhcpthpp..uppth.hphs.................thpph.ssGY..YG.+Gtph.............hsptlhsc..ats..t.lcphsstst........llp..hh....G.sssasptVLVPElhhhLlhEDM.........sls.........s.cp............................Acpllc-SschGplls..............	0	28	59	104
+14326	PF14475	Mso1_Sec1_bdg		Sec1-binding region of Mso1	Wood V, Coggill P	pcc	manual	Domain	Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction [1], and this binding domain is towards the N-terminus of Mso1. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane [2].  Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p [3]. The C-terminal region of Mso1 (not built) assists in targetting Sec1 to the sites of polarised membrane transport [4].	29.10	29.10	31.30	30.40	28.60	27.30	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.58	0.72	-8.07	0.72	-4.55	22	111	2011-10-27 17:28:36	2011-10-27 18:28:36	1	3	109	0	80	103	0	43.90	40	17.97	NEW	Sulpplp..l...p....sEpDGDTtsDTlVH+sLlpYYppp..tpsaPsWL	...................phtph.....h.....p.........sEs.D.GDoEDsThlp+sLhsYYscK..GpsFPsWL	0	13	39	67
+14327	PF14476	Chloroplast_duf		Petal formation-expressed	Coggill P	pcc	Pfam-B_480 (release 25.0)	Family	The members of this plant family from Arabidopsis thaliana appear to be proteins found in the chloroplast, expressed in the pollen tube during the petal differentiation and expansion stage. The function is not known.	25.00	25.00	44.50	25.00	21.90	21.30	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.03	0.70	-5.63	14	101	2011-10-28 14:10:21	2011-10-28 15:10:21	1	4	16	0	67	104	1	250.10	52	75.27	NEW	KLaAlhEAVADRlEMHcNIGcQRDNWN+LLLsSlNslTLTAAsMAGLA...stuusshhALKlSSTlLasAATGhhslMNKIQPSQLAEEQRNAsRLF+QLcppIcssLulsss........spsDVp-AME+VLALD+AYPLPLLGuMLEKFPpoVEPAsWWPppcppptcppt................tttpuNGWSpELE-EMRcllpVLKtKDpp-Yl+LGclALKlNKlLAIoGPlLTGlAAluSAFlGss.....ssWAuhluVssGALAosVNTlEHGGQVGMVFEMYRssAGFFphMEEoIESslpEp-Vc+RENGElFEhKVALpLGRSLS-L+	......................pLhulhEtssDRhEMHc.IGcQRsNWNpLLLpShN.lTLsAusMuulA....s.sussllALKhSuslLh.uAsshhhhhNKIQPSQLsEEQRNAsRLa+pLptpl.pthluhsss........optDVppsh-+VLALDpAYPLPLLs.sML-KFPpphEPAhWWPppc.ptt.pptt....................t.psNGWs.-LE.EMRclltVlKtKD.p-Y.+lGplsLplNKhLAluGPhLsGhAAhuouFlGss.......tsWushlulhsGuhAusVNshEHGGQlGMVFEMYRssuGFaphhpEsIEuslpEt-lt+RENGElFEhKVALpLGRShStL+.......................................	0	3	46	59
+14328	PF14477	Mso1_C		Membrane-polarising domain of Mso1	Coggill P	pcc	PF14475	Domain	Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal membrane fraction [1]. The yeast Sec1p protein functions in the docking of secretory transport vesicles to the plasma membrane [2]. Mso1p and Sec1p interact at sites of exocytosis and the Mso1p-Sec1p interaction site depends on a functional Rab GTPase Sec4p and its GEF Sec2p [3]. This C-terminal region of Mso1 assists in targetting Sec1 to the sites of polarised membrane transport, the SNARES and Sec4 [4].	23.20	23.20	23.20	23.20	22.50	18.10	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.78	0.72	-3.64	7	18	2011-10-28 14:29:35	2011-10-28 15:29:35	1	2	18	0	12	17	0	60.30	31	34.86	NEW	hSup......uSsslp.....+suSclpDsaNSp+DsS.hp..Gosptuh...PAps.sssustpGS.LRu	........................................................tusshp........RSSSRLQDhYNKSRQQS..hPGsGYso................................	0	2	7	12
+14329	PF14478	DUF4430		Domain of unknown function (DUF4430)	Coggill P	pcc	JCSG-Target:417407-SP17946A	Domain	Although this family has overlaps with SLBB, the majority of its sequences are unique. Several family members, eg UniProtKB:A0RGA8, that do not overlap have an LPXTG-cell wall anchor at their C-terminus, a SSF_Family 10_polysaccharide_lyase or Glycosyltransferase structure associated with them in the middle region, as shown by InterPro, as well as this domain at the N-terminus.	30.00	30.00	30.20	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.20	0.72	-3.92	123	701	2012-10-03 10:59:06	2011-10-28 15:57:49	1	52	462	4	173	592	41	69.30	29	19.69	NEW	usolh......csLc.....p....pt...plpt..p...pt.........thG....alsuI...sG.....h.p.p.........c..tsss.ph.....WhapV.N.Gphssh.....Gusphpl.c.sGDp.lpat	..............................................................polhslLp.......c........st....clct..p.......s............G.....alsuI....sG....................ltp...............c..ssp.sh.......WhapV..N.Gphssp......GAsph.....pl.c.sGDplpa...........	0	62	111	129
+14330	PF14479	HeLo		Prion-inhibition and propagation	Greenwald J, Coggill P	pcc	Pfam-B_407 (release 25.0)	Domain	This N-terminal region, HeLo, has a prion-inhibitory effect in cis on its own prion-forming domain (PFD) and in trans on HET-s prion propagation [1]. The domain is found exclusively in the fungal kingdom. Its structure, as it occurs in the HET-s/HET-S proteins, consists of two bundles of alpha-helices that pack into a single globular domain [1].  The domain boundary determined from its structure and from protease-resistance experiments overlaps with the C-terminal prion-forming domain of HET-s (PF11558 [2]. The HeLo domains of HET-s and HET-S are very similar and their few differences (and not the prion-forming domains) determine the compatibility-phenotype of the fungi in which the proteins are expressed. The mechanism of the HeLo domain-function in heterokaryon-incompatibility is still under investigation, however the HeLo domain is found in similar protein architectures as other cell death and apoptosis-inducing domains. The only other HeLo protein to which a function has been associated is LopB from L. maculans [3].  Although its specific role in L. maculans is unknown, LopB- mutants have impaired ability to form lesions on oilseed rape. The HeLo domain is not related to the HET domain (PF06985) which is another domain involved in heterokaryon incompatibility.	23.20	23.00	23.30	23.20	23.10	22.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-9.98	0.70	-11.20	0.70	-4.58	65	227	2011-10-28 17:51:32	2011-10-28 18:51:32	1	30	76	5	198	232	0	189.70	16	32.69	NEW	GlulGsh...ul..............uulFssslc.....saphlpsu.........+sau.cDhphhp.l+L-lpchRLhpWGcul.....GLhpss.tpp...........................hssthh...tptlpplLspIpplhp-s..pphpp+athptsssstt................................................................................ppphpphspp.tppp....pshhp+sp......WslhDKcp........FppLlpclpshs-s.LpsLh..Pstptpp............phtptchpth..pptpsLphLpcs	........................................................................................h.sh.ul........htlapsslp...................shphlpss.............pphs.p-hphht.hcLclpphRLhtWucss.....Gl.psttttp......................................................tp..h...tptlhplLtpltphhpph..pphp.p+ath.tst.ttt...............................................................................................................................htthpthhtp.tppp.........hphhp+hp......Ws....lhD+pp........hptllpphpthsspLpplh.....s.ttp.p..........................................................................................................................................	0	27	88	173
+14331	PF14480	DNA_pol3_a_NI		DNA polymerase III polC-type N-terminus I	Eberhardt R	re3	Pfam-B_853 (release 23.0)	Family	This is the first N-terminal domain, NI domain, of the DNA polymerase III polC subunit A that is found only in Firmicutes. DNA polymerase polC-type III enzyme functions as the 'replicase' in low G + C Gram-positive bacteria [1].  Purine asymmetry is a characteristic of organisms with a heterodimeric DNA polymerase III alpha-subunit constituted by polC which probably plays a direct role in the maintenance of strand-biased gene distribution; since, among prokaryotic genomes, the distribution of genes on the leading and lagging strands of the replication fork is known to be biased [2]. It has been predicted that the N-terminus of polC folds into two globular domains, NI and NII. A predicted patch of elecrostatic potential at the surface of this domain suggests a possible involvement in nucleic acid binding [3]. This domain is associated with DNA_pol3_alpha Pfam:PF07733 and DNA_pol3_a_NI Pfam:PF11490.	22.00	22.00	22.60	22.00	21.90	21.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.31	0.72	-4.34	58	1166	2011-10-31 08:26:54	2011-10-31 08:26:54	1	22	1163	0	129	779	4	76.00	29	5.33	NEW	cpFphLhpplp..hssch...thhpsu.plp+lslpcps+pWcFplphcplLPhchapphpppLpps.Fpphs.plphplps	............ppFplLhsQlp...hssph.psthlpsu.pIc+lsVppts+hW-FHlshsplLPh-hahthpptLppp.Fpchu.psshplp..............	0	42	81	105
+14332	PF14481	Fimbrial_PilY2		Type 4 fimbrial biogenesis protein PilY2	Jaroszewski L, Godzik A	lukasz	Pseudomonas aeruginosa PAO1 gene PA4555, JCSG target SP18988A	Family	Members of this family were experimentally shown to be involved  in fimbrial biogenesis, but its exact role appears to be unknown.	25.00	25.00	118.80	118.60	22.00	20.30	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.41	0.71	-4.67	9	19	2011-10-31 17:44:58	2011-10-31 17:44:58	1	1	18	2	2	11	0	112.70	67	99.54	NEW	MKsL.hL......LALAsPshsaAp-spTFEsuGVV.-VplEpsLVsIDtphYRLPNussps....GhPslFQV+PGSVVSaSGoVSpPhspIssIYIhKQhS...hu....cEp...tuE.ps+	.MKVLPML......LALAVPGLCWAE-PQTFEGAGVVFEVQVEKNLVDIDHRLYRLPNSTVRN....GMPSLFQVKPGSVVSYSGTVSQPWSTITDIYIHKQMSEQELAEMIEKEQPRQDGEEQPR..	0	1	1	2
+14333	PF14482	Cut8_N		Cut8 proteasome-binding domain	Eberhardt R	re3	Wood V	Family	In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome [1]. Cut8 comprises three functional domains. An N-terminal lysine-rich segment (this entry) which binds to the proteasome when ubiquitinated, a central dimerisation domain (Pfam:PF14483) and a C-terminal six-helix bundle (Pfam:PF08559), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding [2]. Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8 [1]. Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome [1]. In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 [1]. Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum [1].	22.00	22.00	23.70	23.70	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.34	0.72	-8.84	0.72	-3.97	19	98	2011-11-01 13:47:55	2011-11-01 13:47:55	1	3	96	0	68	85	0	55.20	33	17.09	NEW	phpspps.tpR...KRpus--.......pp..hsP....ssp.t........h.spth.........................ts++Kh+.tsplpGpP	...........ppss.ssR...KRKA--D........t.sschohSP.......osSPu........hssRsls.........................sp++hR.psplsGRP.	0	10	27	51
+14334	PF14483	Cut8_M		Cut8 dimerisation domain	Eberhardt R	re3	Wood V	Family	In Schizosaccharomyces pombe, Cut8 is a nuclear envelope protein that physically interacts with and tethers 26S proteasome in the nucleus resulting in the nuclear accumulation of proteasome [1]. Cut8 comprises three functional domains. An N-terminal lysine-rich segment (Pfam:PF14482) which binds to the proteasome when ubiquitinated, a central dimerisation domain (this entry) and a C-terminal six-helix bundle (Pfam:PF08559), which shows structural similarity to 14-3-3 phosphoprotein-binding domains. The six-helix bundle is necessary for liposome and cholesterol binding [2]. Cut8 is a proteasome substrate and the N-terminal segment is polyubiquitinated and functions as a degron tag. Ubiquitination of the amino N-terminal segment is essential to the function of Cut8 [1]. Lysine residues in the N-terminal segment of Cut8 are required for physical interaction with proteasome [1]. In fission yeast the function of Cut8 has been demonstrated to be regulated by ubiquitin-conjugating Rhp6/Ubc2/Rad6 and ligating enzymes Ubr1 [1]. Cut8 homologues have been identified in Drosophila melanogaster, Anopheles gambiae and Dictyostelium discoideum [1].	22.00	22.00	22.30	22.30	21.60	21.50	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.25	0.72	-7.54	0.72	-4.15	19	126	2011-11-01 13:49:00	2011-11-01 13:49:00	1	5	124	3	91	116	0	37.70	39	11.94	NEW	LPLsRLLEsLDpspLpslLpslsppHP-lupplhptsP	..LsLsRLLEoLDpspLpslLpslsc+HP-lspEVhppuP.............	0	14	41	74
+14335	PF14484	FISNA		Fish-specific NACHT associated domain	Eberhardt R	re3	Jackhmmer:A5PF24	Family	This domain is frequently found associated with the NACHT domain (Pfam:PF05729) in fish and other vertebrates [1].	22.90	22.90	23.40	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.39	0.72	-9.26	0.72	-4.00	25	1153	2011-11-03 14:27:53	2011-11-03 14:27:53	1	57	42	0	826	627	0	71.30	49	11.79	NEW	paKssl++KapslhEGsuppussshLNcIYT-LYIsEGcSspVNpEHEVh.QhEppu+ppssp-TPIpCpDIFp	.............phKssLK+KapplFEGIuptGssTLLNcIYT-LYITEGtotpVNpEHEVR.QIEssS...Rp....p..............sp.-oslcs..cDlFc..................	0	2	385	784
+14336	PF14485	DUF4431		Domain of unknown function (DUF4431)	Coggill P	pcc	Jackhmmer:E7X0E8	Domain	\N	24.00	24.00	24.50	24.00	22.90	21.20	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.00	0.72	-8.20	0.72	-4.35	23	127	2011-11-04 10:52:06	2011-11-04 10:52:06	1	4	112	0	11	66	0	49.00	47	13.24	NEW	plQLsl.sssphshhcp.....hlGKcVpVs.GclhhupouaHaTPlLLs.lspls	..........h.VQLlL.sPEcashapp.....alGK+ITlp.G+VMlAcShaHhTPVLLs.lpc..p....	0	4	7	9
+14337	PF14486	DUF4432		Domain of unknown function (DUF4432)	Coggill P	pcc	JCSG_target390294_A6THE6	Family	\N	32.00	32.00	32.30	32.40	31.50	31.30	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-11.59	0.70	-5.87	63	706	2012-10-02 23:57:29	2011-11-08 15:18:22	1	2	605	3	123	495	53	292.50	33	85.99	NEW	scGschlplps...uGLphsllPsRGMDlh.....csphp...Ghs.luWpSPs.s.hlsPshhs...psGhGWLcuFs.shlspCGLptsGsPs..s.-s..........ut..............h..........sLHGRlustPAcplsh.ph..p...-..p.s.htlplpGplcEsphFGtsLpLppplpsphGps...plplpDplsNpust.spsh.hLYHhNhGhPlL-csuchh..................hPs.pplsst....s...spAtp...shssapphtsPps...s.a...sEpVahhc..tuDtsG.pshshlhNtph...shG...lslpFspppLPhhs.WKshss..tsYVhGLEPu.Tshshs.+sht+cpGplhtLtPGEs+saplphpl	................................s.pGlculclpN..upG.plhllPhhG....Ih.....cA..pac...Gps..Lshpshh..p....pPt.ht.......ph.lcoas.sahh+sG....L.....ts....GsPu....s.-D......................ha..........sLHGchsssshcc.shl.ch..c...s.....tlplsGchc.shs.F.Gcca.hspsslshchuSs...hFcIp.pVTNhu.sh.shPLQhhhHhNauas.......ssAphp.............................tPs..tphhsh....N....pch.hp.........G.s.s...hpols.tPph...h...............sEhVahhc...h.sc.......ps.psthth..hsscu........ps...hss+FsospLshhTpWhhhsup......ppshshuL...Pu.Tsp.P.-.G..hhst....pt.pGp.LhpLpPtpo+sFslohu.................................................................................................................	0	40	61	87
+14338	PF14487	DUF4433		Domain of unknown function (DUF4433)	Bateman A	agb	Jackhmmer:A0YHY7	Family	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 201 and 230 amino acids in length. There is a single completely conserved residue E that may be functionally important. This family is distantly similar to Pfam:PF01885 suggesting these may be ADP-ribosylases.	22.50	22.50	23.30	24.20	21.90	20.90	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-11.41	0.71	-4.59	53	218	2011-11-08 17:28:40	2011-11-08 17:28:40	1	5	201	0	55	181	25	184.10	25	79.79	NEW	aHIsHlcNLsSIlpsGhLhucsplhppthshssIu.spIpp+Rhtp.slsstsutplt-YVPF...YFsPRSsMLYtI.ppss.....htttp...psIlhLtssl.ptlst.....t.phsFo..susAusphschhs.............sL...ppLt.pl-Wshlpu........p.Wp.........pp+ct+QAEhLlc.pphPhphlppIsVhspshtspVpphlttts....................hp.sVplpss....WYa	...................................................................aHhTHhcNLssIl..psGhLhucstl....hshsplu.s.lhphRtt......sh.ssshhpDaVPF...Yh.s.spS.sMLasl.pttps...........pt........ttslVhLsssl.chlst...........thsasao..sssAss.sh..sphh.s..............pl......spLt..lcas.hlpt...................cpapps........t...p..s.sp.pcppAEhLlh.pplPhphlpt..lsshspphhpplpphlt.hs.............h...h.hpst..hYa.............................	0	20	35	44
+14339	PF14488	DUF4434		Domain of unknown function (DUF4434)	Coggill P	pcc	JCSG_Target_393000_GS13553A	Family	\N	30.00	30.00	30.00	30.40	29.80	29.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.19	0.71	-4.52	39	420	2012-10-03 05:44:19	2011-11-09 11:13:28	1	8	375	0	32	218	17	167.10	53	52.21	NEW	loGTFlp.hp.s........c...........pshssspWcpchpth+plGhcsll.....lp...............hsuhps.tshhP.oph......t..h......s...shlphhLstAc+hGMclahGlhhss....paWc..p...pshph.......p..hthspt........lhcE.lhp..haup.at..uFt..GWYlshElspt...s............hss.......ssth....ptls.ph.hcplus.......shPsh..lSsahsst	...................MKGIIWQPQNRDS............QVTDTQWQGLMSQLRLQGFDTLV.....LQ...............WTRYGD.....AFTQP.EQR..................sLLFKRAAAAQQAGL....KLIVGLNADP....EFFM.HQ...KQSSAA..............LESYLNRL.............LAAD...LQQA.RLWSA.sPG..lTPD..GWYISAEIDDL....N..............WRS............EAAR....QPLL.TW.LNNAQRLIS.DVSAKPVY..ISSFFAG.N......................	0	10	23	26
+14340	PF14489	QueF		QueF-like protein	Bateman A	agb	PF01227	Family	This protein is involved in the biosynthesis of queuosine.  In some proteins this domain appears to be fused to Pfam:PF06508.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.67	0.72	-4.03	30	2821	2012-10-01 20:59:24	2011-11-09 15:46:40	1	7	2788	25	550	1754	742	79.10	46	38.24	NEW	PDFAolhlcYhPspphlEhKSLKLYLhSFRscshFHEpssNpIhcDllpthcPcalcVhucFsPRGGlshslhsppsctss	...................PDauolhIpYhss.p...l-pcuLhhYLhSFRpHs.-FHEpClppIhs.DLlchh.pPchLpVau+.aT.RGGlsIsPaps.s...sh......................	0	155	323	442
+14341	PF14490	HHH_4		Helix-hairpin-helix containing domain	Bateman A	agb	Jackhmmer:A0YV56	Family	This presumed domain contains at least one helix-hairpin-helix motif. This domain is often found in RecD helicases.	27.00	27.00	27.00	27.00	26.30	26.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.02	0.72	-4.22	189	1795	2012-10-03 02:11:09	2011-11-09 16:09:58	1	16	1618	4	349	1402	107	94.40	34	12.36	NEW	shpcpps..hcclhhhLppaGlss.p..hAh+Iapp..Yu..s.....pul..cllccNPYpLsp-l......pGlGFppADpIAp....p.h......GlstcsspRlpAulhasLpp.s.t.ppGHsa	.................................tppshcplhhhLpsaGlus..pluhpIapt..Yt..p.........co.l..pllcpNPYpLlcDI......cGIG...FppADplAc....p.l...................GIs.s..s...sscRl+Aulha.sLpp..sh.ppGcTY.....................	0	137	248	310
+14342	PF14491	DUF4435		Protein of unknown function (DUF4435)	Bateman A	agb	Jackhmmer:A0YK45	Domain	This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 285 and 362 amino acids in length. This domain is sometimes associated with AAA domains.	27.00	27.00	27.10	27.20	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.79	0.70	-4.54	54	311	2011-11-09 16:32:35	2011-11-09 16:32:35	1	5	276	0	51	265	2	230.50	19	66.66	NEW	c.+lhsaVEuh..DD.h.aacslls..ph....ps.c...h...c.h.ap......................stGKcsVL.phhphh......ppt..sspshlh.hVDsDa..........Dhl.......h.tt.........ps.s...hla...pT.sYu.....IENhhs.hs.pulcclhsth.sls-..............hh.c..apphhppapctl..hslhl...a.hhhh......cpt.....phhshpps..l.ph..............ps.hphpph.hph.......phpplphp...hphpplpphh.p...th..............................c...ps...h.pplppclppl..s...ps..h.....p..hhh..pG+.....alh......hl.h...hlp.plhpph...pp..cppp	.....................chhhaVEGh...cDh.aapsl...ls..ph....ps.c.....h.....p.h.h.......................stGKppVlts.thl.......psp......hspshlu...hlDsD.a.................Dhl......httt..............psp....lahT.sas..........lENhhh...hs......pslcclhs...ph.....phss.....p......th.......hc...h.p.t.hh..pp.hp....phl.hslhh.h.hhhh...ppt.............thpph..l.ph.............pphphpph...p......p.tphphp...thhpplpphh.p...th...............................p...t....h.pthppphpth.....t...ts..h..........h....hh..pGH......lhp..l.h..hhh...htp..........pp...................................................................................................	0	15	34	48
+14343	PF14492	EFG_II		Elongation Factor G, domain II	Bateman A	agb	Jackhmmer:A0YMC3	Domain	This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679).	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.15	0.72	-4.13	129	11565	2012-10-02 20:07:24	2011-11-09 16:50:22	1	54	5577	56	3004	8396	3438	73.30	37	10.91	NEW	hPcPVlshAlcP...cs...csDp-KlupuLp+lhcEDPohplppcpETspslluGMGELHL-lhl-Rl+ccatl-lplup	...........................PpPVlphu.lEPKs......psDp-Kh............sp...........ALp.+LscEDPoh+lps.....cp.E...o...u...p...pl.....luG.....h.......GELHL-lll.-.Rhc+Ea..p.l-spht.t.............................	0	1071	1868	2539
+14344	PF14493	HTH_40		Helix-turn-helix domain	Bateman A	agb	Jackhmmer:A0YXF4	Domain	This presumed domain is found at the C-terminus of a large number of helicase proteins.	27.00	27.00	27.00	27.30	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.76	0.72	-3.77	166	1114	2012-10-04 14:01:12	2011-11-09 17:27:19	1	26	983	0	236	851	57	91.20	26	16.58	NEW	sotphThpLa....p.p..G.holc-IAp....pRs......LphuTI.sHLschhpp..Gt.....l....s....l....p....ph..l..sp.....c.....c.hppItpsh.......pp..hs...........................s...p.......pL+sl+E..tLspp.hoYtpI+lshs	.................othhTaphh....p.p..G.holc-IAp....pRp......LphsTIpsHllchhhp..Gh.....h....s....h....p....ph......l.st.............-.....c..ptlh...p..hh.......pp...hp....................................s...p.........cL+.lK-..thst....p.loYhpl+lhl...............................................................	0	89	170	209
+14345	PF14494	DUF4436		Domain of unknown function (DUF4436)	Coggill P	pcc	Pfam-B_6430 (release 25.0)	Family	This is a family of membrane and transmembrane proteins from mycobacterial and related species. The function is not known.	23.00	23.00	23.00	23.00	22.40	22.90	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.69	0.70	-5.09	15	176	2011-11-09 18:28:06	2011-11-09 18:28:06	1	3	96	0	47	101	5	244.90	40	77.13	NEW	ushlhspo..ssshsps-suh..u-posVplslEclcossscLsVsVhVtPssuLlDschpsLssDluVRlpusss.u-lpascGphPushsss.lshsGchpsWPFDpYcoss......lss......-lhsGsGss+tshPupVchsGs.LsGWslshspsscss.........sssshplsLcRStuslsFslsIshVLIuLPslALhVAIphspsRRpFpPPhsTWaAAMLFAVVPLRNhLPGoPPhGuWIDhsVVLWVLlALVsuMllYIlsWWRph	...........................................................s..hhhpo...s...psshup..sDsTsVhl+hEpLpTltshLssplh.V.PssphlDpp.hp.sLpsDhoVp..lh.s.s.p.schpassGpLPu...hsss.lp.h.p..Gs....Pus..WPFDpYposs......lps...............plhhGu...u.............+t..h.s......pVp...hssp..L....G..Wslshs..t.Vu-us.................tssshhlsL+.....Ruhusls...........F..slsIshVL.Is.Lsslu...L.F.V.Al..QhhpGR.RpF...Q...PP...h..sTWYAAMLFAVlPLRNhLPGuP.P.....h.GuWIDhsVVlWVllALssuMVlYIlsWahch.......................	0	27	37	43
+14346	PF14495	Cytochrom_C550		Cytochrome c-550 domain	Bateman A	agb	Jackhmmer:Q55013	Domain	This domain is a heme binding cytochrome known as cytochrome c550, or cytochrome c549, or PsbV [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.73	0.71	-4.71	49	117	2012-10-03 10:02:11	2011-11-10 14:07:10	1	1	98	25	35	180	43	133.90	48	82.64	NEW	hcLDc.........pscTVsL.......sssGcTlsloscQlppGK+LFsssCupCHsGGl...TKTNPNVuLs.-sLuhAoPsRDNltuLVDYhKsPToYDGpcsIuElHPuhcSuDlaPcMRsLo--DLhslAGaILlpPKlhuppWG....GGK........lYa	.......................hpLscpohTVslsspGpTlsloscQlppG++LFsssCupCHsGGl...TKTNPNVuLs.EsLuh.A..T.Ps..RDNltuLVDYhKsPToYDGp-sIuElHPSlcSuDlaPcMRsLT--DLhslAGaILlpPKlsuppWGGGKh....................................................	0	10	26	33
+14347	PF14496	NEL		C-terminal novel E3 ligase, LRR-interacting	Coggill P	pcc	Jackhmmer:E7K2H2_PDB:3ckd	Domain	This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred [1].	23.00	23.00	23.10	23.40	22.30	22.40	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.43	0.70	-5.06	37	676	2011-11-10 15:41:18	2011-11-10 15:41:18	1	44	233	6	57	677	1	198.20	45	29.38	NEW	WLtssstps.p..phttWpshppEpsussFsphLscLppossaptts.....shpppVhphLpthspcspLRpphFshAtssp......toCpDplsltasshchshhl....tsscssph-ss.....LlphuRphaRL-tL-plApc+ltph.t...............sD-lEVhLAapspLtcsLsLss..spcMhahslSslopsDltpApspV.........ppppspthhpalup.pshWcshLcchpssca	...................................................Wh.s.pcps.....sp.W+uF..-pEppA..ssFStFLDRLu-T.ss+pss...........sF+cQVuAW....LtpLus...........s....spL..RppsFsl..At-AT.......tSCEDR.VsLsasphcpshLV....H.pApcGhaDsch..stLlshGREhFRLE.LEsIAR-..KV+pL..h............................................h...lDEI...EVaLAaQsh....Lt-pLpLoo.hsp-MRFas...VS.GVTssDLcsAEthV.........+stEpp-FpcWhuh.WuPWHsVLcRpts-ca......................................................	0	4	12	27
+14348	PF14497	GST_C_3		Glutathione S-transferase, C-terminal domain	Bateman A	agb	Jackhmmer:Q7WQ90	Domain	This domain is closely related to Pfam:PF00043.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.62	0.72	-3.52	199	1536	2012-10-03 01:14:49	2011-11-11 11:56:35	1	53	641	37	886	5329	1288	117.80	14	30.20	NEW	tpthphsh........hs.....Whs..................................................................tptsppcl.ptlphh.....sptL...stps...............alhGsp..h..................ohsDl....s...las....hl........tshp..at.....h..................tsh.......................p......lhp........ahsplpp	.....................................................................................................................t.........................................................................................................t..t....t...h...t...p...ts...p...p...c...l....p....h.h.pth..........pptL.........spps..................alhGsp.....................ohADl......s........l.au..........hL...................tsht......hs.....hs...........................pphs.......................sltpahpplp..............................................	0	254	427	678
+14349	PF14498	Glyco_hyd_65N_2		Glycosyl hydrolase family 65, N-terminal domain	Bateman A	agb	Jackhmmer:B5CKV7	Domain	This domain represents a domain found to the N-terminus of the glycosyl hydrolase 65 family catalytic domain.	27.00	27.00	27.30	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.62	0.70	-4.68	86	1312	2012-10-02 23:57:29	2011-11-11 13:22:47	1	57	676	9	328	1063	38	230.20	29	29.24	NEW	LaaspP...............Asp..................Wp......cuLPlGNGplGAhlaGsss.....pEplplN-colWoG..uspssps.s..............................s.thlttlRphlhpscht.........pupplhtphhtstst.................t..YpshGsLhls............ts...pssss.............sYpRpLDLssulssssaph..su.............spa..........pR-hFsSh...PD.........sVlV......h+l.puspsttl.shslplsss...................psssssspssplphpGph.....................tssulpaputl+l.hssuGsl...tsps................sslplp....sAsplslllsssTsapsp	..........................................................LhYppP...................Asp.................................Wp...-ALPlGNGpLGAhlaGshs.....pEplQhNEco.lWsG......ustsps.sst..............................th.hL.p.lRp....hl....p.schp...........................tAp.p.Lhppphhu..p...........................up.Y.shGclhlc........................ths...tspho.......................sYpRpL-lspAlus..ssaph..su.......................spa...........pREhFsSh.....sc...................slll......h+h.ous.t........t.p.......l..sh..s..lplsps.......................................ppthhshsssplhh.p.Gps......................................................tpsslp..at....sh..h..th...htss.Gpl......ps.s....................spltlp...sAs.psslhlsutTsat.....................................................................................................................	0	123	253	301
+14350	PF14499	DUF4437		Domain of unknown function (DUF4437)	Eberhardt R	re3	Jackhmmer:B2J7U5	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 152 and 283 amino acids in length.	24.00	24.00	24.00	24.00	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.45	0.70	-5.47	17	81	2012-10-10 13:59:34	2011-11-14 11:54:57	1	2	76	2	32	109	79	171.00	22	81.08	NEW	-llhus-lcWshLNPhRG-tuPuAupLWGDRsssssoGhLV+FpcGFpSPPHIHNloYRGlVIpGtlHNDD.cAtphWhPsGSFWTQPAG....EsHlTAAcuspslhYlEIssGPYLV+PsppsFDsGERPlNlcpsNlVWLsspclsWlpss.......usphsaLWssssstthpGhhl+LPsuFpGplpopussh+AVllpGplsap..p.spspsLtsGSYhsustc..Hpl..ps-pssslYlRosGcaplp	..................................................usthusLaGD.tppushshhl+hssGapssPHhHshs.p.h.hVIpG...t...h......h...s.....s...c....s.t.......hssGuaah.PuG....t.Hhshspst.p.h....h.htpsPh...............................................................................................................................................................h.............................................	0	9	18	26
+14351	PF14500	MMS19_N		Dos2-interacting transcription regulator of RNA-Pol-II	Wood V, Coggill P	pcc	PF12460	Domain	This domain, along with the C-terminal part, Pfam:PF12460 [1], is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2].	21.00	21.00	21.00	21.00	20.80	20.90	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.65	0.70	-5.13	55	354	2011-11-14 16:18:51	2011-11-14 16:18:51	1	16	268	0	250	358	4	225.50	28	24.04	NEW	VpsLGphLTsp-sthRs+ulp.hLosVLppLs.ssh..LscpplplLhsFYps.......Rl..cDptslhss.LpGltuLs.phpp.......hstst...stpllculhpchps..puhhpssRhtsapllpslhppatctL......pshus-Flh.GhlphhsGEKDPRNLllsFplhp.hlhppa.s.............l.spasE-LF-lhhCYFPIsFpPPsNDP.h.sITp-DLptsLcsslsuoshFAphshPhLlEKLsSos.s..sKhDoLpsLttChpsa...sss.slppahhslWsuLKhElhps	................................ht..lts...p..hRt+.uhp.hLstll.th...ph.............Lpppp.....l.thLhtFat.s.......+l..p.Dtth.l..s..hpul.......ttL....h.tt................................hs.s.......s.plh.p.sl..h.p......phps....ps........h.t...t.p...Rhtsapllp.th..h.pp..hp..t.tl......................pths.s..p..ahh..shlp.hhsGE+DPRNLhlhFplhp....hlhppas........................................h..sthsE-lF-sh.sYFPIsFpPss...s.Ds..h...sIotc-Lt.sLptsls.usshF.A......hshPhLl-Kls...Ss.....s......sK..h.....DsLpsL...t..Ch...t....Y...s.....p..pl.ttah.plWsul+hElh..s..........................................................	0	84	137	208
+14352	PF14501	HATPase_c_5		GHKL domain	Bateman A	agb	Jackhmmer:B5CQB8	Domain	This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.36	0.72	-4.30	80	2619	2012-10-11 19:05:54	2011-11-14 17:49:38	1	17	1244	0	315	12868	2588	102.70	24	25.87	NEW	l.pshDlsslhuNlLDNAIEA....spc.........h..p..p...c..+h.Iplpht.t.pp..sh..lhIplc.N.s.....hss.....................ph......sp.....hh......oo..K.p.c.tphH.GhGlpSlcphlcKY.sG.slp..hp.hcss..hFphplhls	..........................................h.p.hDls.pll.u.llDNAI.E..u......u.tc.......................h..p.............pth....l...p...l..s..h.h.....p....p....p.......sp.........h......h.........h.......h.....l.p...Ns........hpp.............................sh..........sc...........lh..........sh....p....s......c.....s..p.....s+....G..l..G..L..p.sl...cc...l.l.c.....p...a...ss.....l..p....h..p....h...p...s..s.....h.F.p...plhl...........................................	0	158	232	280
+14353	PF14502	HTH_41		Helix-turn-helix domain	Eberhardt R	re3	Jackhmmer:D2A9I0	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-7.96	0.72	-4.34	19	338	2012-10-04 14:01:12	2011-11-15 11:51:03	1	2	335	0	28	586	65	47.90	75	16.35	NEW	psG-RlpTIsEhucchsluhGslQsALKhLcspsAlpL-pRG+.GTal	...........KCGNRLKTIDELATECRSSVGLTQAALKTLESSGA.IRIER.RGRN.G.SYL...........	0	8	14	23
+14354	PF14503	YhfZ_C		YhfZ C-terminal domain	Eberhardt R	re3	Jackhmmer:D2A9I0	Family	This domain is often found in association with the helix-turn-helix domain HTH_41 (Pfam:PF14502). It includes YhfZ proteins from Escherichia coli and Shigella flexneri.	27.80	27.80	27.90	49.80	26.90	27.70	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.42	0.70	-5.02	20	369	2011-11-15 11:54:42	2011-11-15 11:54:42	1	2	339	2	28	144	1	210.60	73	75.69	NEW	chphLLphAslsslVssMPLPYS++YEGLATGLpppFcp..slPh...hAaMRGustRlcsLpsGhYDaAllS+LAAcpalcp...cslclshphGs.poYVupHhlla+csppppI....hRlGlDssShDQplLTchhhc.scclEhVElsYsphlptlhpGpIDAslWNh-..chchps.hslphhslpp...pp..hhpcsocAVlllcp-spslppllpphVstcpllphQpcVlpschhPsY	...DNKALLoHVDINNVVCAMPLPYTRLYEGLASGLKAQFD...GIPFYYAHMRGADIRVECLLNG..VYDMAVVSRLAAESYLTQ...KGLCLALELGP.HTYVGEHQLIC.RKG...ESANV.....KRVGLDNRSADQKIMTDVFFG....s.S.DVERVDLSYHESLQRIVKGDVDAVIWNVV.AENELT.....M..LGLEA..TPLTD...DP.RFLQATEAVVLTRsDDYPMQQLLRAVVDKHALLAHQQRVVSGEQEPSY.........	0	8	14	23
+14355	PF14504	CAP_assoc_N		CAP-associated N-terminal	Coggill P	pcc	JCSG:target_417453-SP18049A	Domain	The function of this domain is unknown, but it is found towards the N-terminus of bacterial proteins carrying the CAP domain, Pfam:PF00188. All members that do not otherwise carry an additional Cu_amine_oxidN1, Pfam:PF07833, domain are likely to be extracellular as they start with a signal-peptide. Most other non-bacterial proteins with the CAP domain are allergenic [1].	24.30	24.30	24.40	25.00	23.90	23.40	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.76	0.71	-4.46	63	757	2011-11-15 12:29:15	2011-11-15 12:29:15	1	5	529	0	63	374	0	139.40	32	41.03	NEW	IGpstpplppphG.pPpRhpsspYGacWalYpppstp.Yl.luh.pc..s+VsulYssuspls..hsshclGpstpplhcphshpPphslptssppYphchscc-h.hcslhph.sshY.splahDpa.ssplsul+hlsccshhchpsYt	...................lGpshcslpppaG.pPc...Rlhssta.GachYsYppcspp.YhhVuh.tc..c+VsulYsssptls..luPlKlspppuclh.p.+hulpPEhshphspppYchEh.-c-h.hpsll+h.sclYAplaaDpp..ssplhuVphlscphhsclcPY..................................	0	21	43	57
+14356	PF14505	DUF4438		Domain of unknown function (DUF4438)	Eberhardt R	re3	Jackhmmer:D2C4U6	Family	\N	27.00	27.00	319.50	319.20	21.60	17.70	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.62	0.70	-5.61	31	62	2011-11-15 14:52:22	2011-11-15 14:52:22	1	1	58	35	28	65	22	259.40	51	88.24	NEW	sYcVst-GpshlLPusGGITYNVplGDsshGhsGDHlEPGVSh....+s...sscp......NsuLphhuClGNpAcVlSG-AKGtpGhVTG+HGGl.-HVlVpFscEshEKLslsDpIhI+AhGQGL+LhDaP-lplhNlDPcLLc+hsIcp..ccGtLcVPVsshlPAhlMGSGlGussshpGDYDIhTsDpcssccaGlccLRFGDlVAlhDpDNcaG.RtYpcGAloIGVVVHSDChpuGHGPGlTslMTutsutIcPhlDspANIAshL	....YcVst-GpshllPusGGIoYNlplGDsshGhsGDHlEPGVSh.......+s.......sscp.NsuL.hhuCIGNpApVlSG-AKGtpGhVTG+HGGl.-HVlVpFsc-shEKlslsD+IhI+AhGQGL+LhDaP-lplhNlDPpLL-+hsIpE..ccGtLcVPVsshVPAalMGSGlGuusshpGDYDIMTsDtcssccaGlccLRFGDlVAltDpDNpaG.+tY++GAloIGlVVHSDChpAGHGPGVTslMTutsutIcPhlDspANIAshL..	0	8	16	25
+14357	PF14506	CppA_N		CppA N-terminal	Eberhardt R	re3	Jackhmmer:E0TM64	Family	This is the N-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity [1,2]. It is often found associated with Pfam:PF14507.	25.00	25.00	25.00	25.20	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.50	0.71	-4.45	12	394	2012-10-02 15:00:03	2011-11-16 09:00:13	1	2	368	4	25	213	1	117.00	61	50.78	NEW	hhsPVL+VNNRclN.sFYppoLGhKhL.EEsAhh.hus.t.ptt-+hllEESPShRTRtV-GsKKLscllIKsssPpEIEtLLApGsp.hcpLFKGppGYAFEslSPEsDhhLlHAEDDlppLp.lt-	.........p.IlPsLKsNNRcLNpsFYhcTLGMKsLLEEuAFlS..LGD.Q.oGhEKLVLE.EuPSMRTR......+VEGhKKLu+llVKVpNP.hEIEulLu+s...c.u...l.....c+LYK....Gp....NGYAFElh.SPEsDLlLlHAE..DDhssLhclt.c.......................................................	0	2	7	15
+14358	PF14507	CppA_C		CppA C-terminal	Eberhardt R	re3	Jackhmmer:E0TM64	Family	This is the C-terminal domain of the CppA protein found in species of Streptococcus. CppA is a putative C3-glycoprotein degrading proteinase, involved in pathogenicity [1,2]. It is often found associated with Pfam:PF14506.	25.00	25.00	28.40	25.60	22.10	24.60	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.43	0.72	-3.83	13	384	2011-11-16 09:02:29	2011-11-16 09:02:29	1	4	382	4	26	177	0	99.50	49	40.97	NEW	LSpFpl-slsLNVPs..c.ucuFYcs...splshsl-FppupGsDLslssslTWDLEhLEapVs.-aDlsuL+sphEs..pps..YlDK+cKlLVhoDsSpIElWFp	.............................................LSpFEI.ShELplPs..c.hcuFL-s............................scl.............s........soLcFl.AQGpDLsVDNslTWDLoMLKFhVs.-hDlAuLRp+FEu..p-a..FIPKS-KFhLscDpsNlELWFE..	0	2	8	16
+14359	PF14508	GH97_N		Glycosyl-hydrolase 97 N-terminal	Coggill P	pcc	PF10566-seed	Domain	This N-terminal domain of glycosyl-hydrolase-97 [1]contributes part of the active site pocket. It is also important for contact with the catalytic and C-terminal domains of the whole [2,3].	25.00	25.00	29.50	29.50	22.50	21.80	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.95	0.70	-5.41	243	798	2011-11-16 12:22:34	2011-11-16 12:22:34	1	17	279	12	179	796	147	258.40	27	38.27	NEW	lsSPDGplplsl.......shs.s............p.sYslpa.....puctllpsStLGlphptss........................hspshp.lhssppssh.ccsap.sh.GcppplcscaNElslshp.ptts..............t.htlpFRlasDGlAFRY.p..hstp.tsht.......hhl.sEtTpFsh..ssstpuah.....hs.t.t................hs.........saEt.Yppsslsph............pt.............................hsphPlhhcst..s.s..halslpEAsLhs.YsuhtLp.ss......ts.shpuths.ssts....................t.tsh.h..........psshsoPWRslhlucssssllp.osllhsLs.-P	............lpSPDGplplsh......slsts............pssYplsa........cscsllpsStLGlphpsss.............................h.spshp..lpssp.ps.s..D-sap.sh.Gcpppl+scYNElslshppsts..............tth.lpFRlasDGluFRYp......hPpp..tsht.......hhlpcEtTpFsh..s.sst..p..uahhs.s..s...................ap.................saEt.Yppst.l.sch.........pt.............................hsphPlh.hcss...c..G...halslpEAuLh...s..Ys..uhpLp.ss......pstshpuths.ssts............................s.tsh.h......psshsoPWRslhluccstsllp..oslhhsLscP............	1	71	152	171
+14360	PF14509	GH97_C		Glycosyl-hydrolase 97 C-terminal, oligomerisation	Coggill P	pcc	PF10566-seed	Domain	Glycosyl-hydrolase-97 is made up of three tightly linked and highly conserved globular domains.  The C-terminal domain is found to be necessary for oligomerisation of the whole molecule in order to create the active-site pocket and the Ca++-binding site.	25.00	25.00	40.20	38.70	20.50	24.80	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.13	0.72	-3.92	195	791	2011-11-16 12:46:07	2011-11-16 12:46:07	1	17	276	12	177	794	106	99.50	33	14.68	NEW	ssWD-TchLpuc.sG-YlslAR+s.......ss.sWalGuhospsuRs..lplsLs.FLs.pG..tp.YpAplYpDG.sAsh......sspsa...plpp...ppV.sspspL.plphAsGGGhAlplh..	....ssWD-o+hLcuc.sG-......YlslAR+p...........us.sWalGulss..p..psRs..lplsLs...FLs..tG..............pYpA....plYpDutsAph.......sspsh...........phcp............tpV..ssp.spL..plphusuGGhAlplh.............................	0	71	153	169
+14361	PF14510	ABC_trans_N		ABC-transporter extracellular N-terminal	Coggill P	pcc	Pfam-B_101 (release 25.0)	Domain	This domain is found at the N-terminus of ABC-transporter proteins from fungi, plants to higher eukaryotes. It would appear to be an extracellular domain.	25.40	25.40	25.60	25.50	25.30	25.20	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.63	0.72	-3.89	317	1186	2011-11-16 17:21:30	2011-11-16 17:21:30	1	43	200	0	805	1238	0	101.70	20	7.47	NEW	Lspphsp......................................................t..............D.....s..pL..s.........spsc............s.F-.scpal+plhchhspsuhp.h....phGV.sFcsLsVpG.u..suschtsTl.sNhhhs	.........................................................................................................................................................................................D.....tpL..s...........spsc.......................................p.ac.s.cpal.c..p..h...t...c.t...h.c..p..s......Ghph.....plGV.tacsLsVpG.u..sssp.h.sTl.hNhhh...........	0	147	445	691
+14362	PF14511	RE_EcoO109I		Type II restriction endonuclease EcoO109I	Coggill P, Eberhardt R	pcc	pdb_1wtd-Jackhmmer:Q9RPJ3	Family	This is a family of Type II restriction endonucleases.	22.50	22.50	22.90	23.20	20.40	20.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.10	0.71	-4.91	22	53	2012-10-11 20:44:47	2011-11-17 13:56:36	1	2	52	4	15	47	3	194.80	28	76.72	NEW	pl.ppscpalcppIsphHp+phppL.ppLcLhclLc.KNPaLF+.spslLous-llcullcAa.....LuSs-EThFGs.alEsLAhalsptshts.p......SshpGIDlEF.....ppDup+hhlslKSGPNhhNusplpphpscF+pstphlRos.t.shphsslsGssYGccpp.sps....................cYhchsGQcFWphlo.G-cshYhclI-slGctAcEps	..................................................t....thpphht..I...p.+thp.h.pphp..pl....NPaLac.hpsl.sup-hsculhcAh.....luouc-TsFGs.hhppLhhhlspssh.................................SshsuhDlEh.....ppDGphhllplKSGsNshNpspl....pplp....pcF+phtsphR.....shs.psl.sGlsYGcssp.sst.p.h...........................t.cYhhlsGpcFWpalo.G-cshYtclhcsls.hApEhs.............	0	5	11	14
+14363	PF14512	TM1586_NiRdase		Putative TM nitroreductase	Coggill P	pcc	Jackhmmer:Q9X1S2_pdb:1vkw	Family	Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.	27.00	27.00	27.00	27.10	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.41	0.70	-11.35	0.70	-5.14	5	84	2012-10-02 14:48:17	2011-11-17 16:31:20	1	1	81	1	19	82	2	203.90	23	84.37	NEW	MNIFEAIENRHSVRDFLERKMPERVKDDIENLLVKFITKKLDWKINLSSFPSYIYAKAEKHFDELVEYGFQGEQIVLFLTAQGFGTCWMARSPHPDVPYIIVFGYPRTRNFTRKRRPITSFLENDLEELPPEIVKIVEMTILAPSALNRQPWKIKYTGGELCISSERPVDLGIALSHAYLTAREIFKREPVIQKREEDTYCLILNP	.......................................................................phh-hh..R+SVRpa......pctl........s......pp.......l......h.....p......pl...........p..........s..........l...................h....p....h............l.......h...c.p.......h.....t....h..p....h....p....h................s...............p..........h......sp...Y.....l...........s.hh...ucc.pt.........s...h...h.p.............p.hGYhuEplVLhhpslGLuTCW...l.........u........h........s.....................p.....t...........c.............l.........s.......h..l..I..s..hGa...s........p.s..p....sh......s..c.....+..........p..+.sh.......pp..h.hp...t.............h....p-..hs..p.......h..h..p.hlcushLAPoAhNpQ.a.......h..h.........h.p.s.s..pl...........h.........h..............................................................................................hthttt............................................	0	13	19	19
+14364	PF14513	DAG_kinase_N		Diacylglycerol kinase N-terminus	Eberhardt R	re3	Jackhmmer:P23743	Family	This domain is found at the N-terminus of diacylglycerol kinases.	23.00	23.00	23.00	23.00	22.80	22.80	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.00	0.71	-3.97	9	283	2011-11-18 15:00:42	2011-11-18 15:00:42	1	30	72	2	119	251	0	118.70	37	20.79	NEW	tpccWspLSPpEFsQLQKYsEYSTKKlKDVLcEFptsGshspYsPc-.......sIsaEGFchFMKsYLEs-.lPccLspHLFhSFps+.pp..................................ss.sscSKst.hpush+.................p.ssVlpLKDlVCYLSLLEsGR	................................................ph..loPt-FtQLQcY....-..Y.S.oK.KlpDVLptF......t..s..G...h....t....pY...tt...................sIsa-GFchFh+saLEs-.lPpchst+LFhSFppp....p............................................................................................................................s.t.....t...tp..................t..........................................h..l.LpDlsCYhSLLEtGp....................................................................	0	22	32	67
+14365	PF14514	TetR_C_9		Transcriptional regulator, TetR, C-terminal	Coggill P	pcc	pdb_2qtq	Domain	This family comprises proteins that belong to the TetR family of transcriptional regulators. This family features the C-terminal region of these sequences, which does not include the N-terminal helix-turn-helix.	25.30	25.30	25.30	25.30	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.63	0.71	-4.33	4	174	2012-10-03 00:15:22	2011-11-21 15:07:58	1	2	158	5	45	121	5	127.00	28	58.91	NEW	DMSPpAKLRRHlutsIcTYacYPYLpRLLhtLhRDusEtpARcIAcpYlpPLtcAYpRhIptGVtsGsFRPlDPQLFYFsVhGAsDphFSuRhVL+asaG.DplsEpLRcpYpEpsl-hIMuGlLA..tc	.......................................................s.....tthphhlptl.hctYh....ch....P.h.RLl...p.s....hpp...st..tt....t...p.ppl.....lcp.....hlt..P.lscslp.sll.EcGlctGlhR.p.lDP.hhalolhuLshah.a...sp.sLttla.Gh-..hup.phhcphlctshpLlhtGh......th...........................	0	12	24	34
+14366	PF14515	HOASN		Haem-oxygenase-associated N-terminal helices	Coggill P	pcc	Jackhmmer:Q9HY91, pdb_3bjdA	Domain	This domain represents a pair of alpha helices, which are found at the N-terminus of some Haem-oxygenase globular domain.	25.00	25.00	123.70	121.40	21.00	19.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.01	0.72	-3.61	2	32	2011-11-21 16:17:14	2011-11-21 16:17:14	1	2	16	3	2	30	0	86.30	68	26.25	NEW	hopRshS..th.....stutllA-ALtsuAohcQIp.AhpAlhAlTtKuLtGDtpAYAtYQtLLh.LplusDs.Tt.TRRWhAstlYhVE-RF	.hspRshS.Pth.....ptutllA-ALtstAo.cQIs.AhptlhAlsttGLtGDtpAYAtYQtLLh.LplusDstTt.TRRWhAptlYhVE-RF	0	2	2	2
+14367	PF14516	AAA_35		AAA-like domain	Bateman A	agb	Jackhmmer:A0YLR5	Family	This family of proteins are part of the AAA superfamily.	27.00	27.00	27.00	27.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.97	0.70	-5.80	99	465	2012-10-05 12:31:09	2011-11-22 16:51:27	1	74	91	0	172	633	10	318.70	25	46.18	NEW	hPpGsls.LsSsFYlERs.....PlEppsYppIhpP.Gu...LIRIKAP+pMGKTSLlsRlLspAppp....uYpoV.LshppADpsl.hssL-+....FLRWFCsslo+pLpLt.....s..pL.....--YWD..-thG..SKhsC.otYFccYLLppl........s.pPLVLuLDEVDclFpaPclApDFhsLLRuWHE.cu+....ppplWpKLRLllVHS..TElYls.LslNQSPF.NVGLsIcLscFohpQVp-LApRasLs.hstsp.....lppLMshVGGHPYLl+LALYalsp..............p...plT........LcpLLppAsTps..G.IYscHL+cphhpL.pppP....-LspAhppVlp.us.pslpL..-shtuaKLcShGLVphp..GsplhspCp.LYRpYFpc	..............................................................................h...s.l..ss...Yl.R..........h-p.hhptl.....hp..Gp...h.hhlhssRQMGKoS.L....h.hch...h.....pphp.p.p..............s.hts...s..h....ls.hp.t...h..s...s....t............hs.s...hpp.............ah.p..hh...s..tpl...sp..p...l..p..L................................t......pl.......p..ph...W.p....c..p..hs.........sh...ph.....sp........ahp..p..h..l..Lt...ph...............s..ps...l....V.lhlD....E....l..D...p...l...h....ph......s.....h..h.......p.-F...h...shlRthap....ppt.......p.ps.a.p+.Lphsl....ht....s.......Tp.s......l......h.....hc........h.......s......p......oP......F.....Nl..G.h..s.lc....Ls..sF....sh.pp....l....p.s....L....h....p....t....h....t....h.p.....hspsp......lpplh.t.hs....uG..p.P.aLspth.hhhl.sp..........................................................p....phs................lpp.l.l.pp....t.h.h...ps.......t.......s.....p...HL....cp.h......h..ppL.....p.p...............cLht....hhp......pllp.........t.....t.....p..............h..t.h..........p.....s.......t.t..h..pL....h.GLlhhp...ts.tlh.ts..lYpthFt........................................................................................................	0	31	126	171
+14368	PF14517	Tachylectin		Tachylectin	Eberhardt R	re3	Jackhmmer:Q27084	Family	This family of lectins binds N-acetylglucosamine and N-acetylgalactosamine and may be involved in innate immunity [1-3]. It has a five-bladed beta-propeller structure with five carbohydrate-binding sites, one per beta sheet [2].	25.50	25.50	25.50	25.70	25.30	25.20	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.04	0.70	-11.88	0.70	-5.03	8	90	2011-11-23 07:54:36	2011-11-23 07:54:36	1	9	23	1	14	107	1	124.10	40	56.07	NEW	auVspDhclptGssPcstsDsa...hsRAsplG+..hsshchlhhuPsGcLYuVcuu...pLYpG.pshsosuspWh.upu++IGcGuWspF+......FlhFDPsGlLYAVotsGpL..YRussPss-spsWhttpAshIGspGWssF-sLFFcPpGhLYuVs.scs..cLhKph.PPsussDcWLu.uoollupuuW.cs.s+FluFossGsLauV.cssGtl..Y..RstsPppssssYhccAphlGs.uaspa+h	.....................................................................................................lYulp.ss....hYpt.....pps..ssph....h.tss.....thIGpu.WttFp......hlhh.ssG.LY..GVss.s..pF..Y+RsP..PTHuSDNWL..G..SAchIGoGGW+s...FphLh.................................................................................................................s............................	0	6	9	14
+14369	PF14518	Haem_oxygenas_2		Iron-containing redox enzyme	Coggill P	pcc	Pfam-B_412 (release 26.0)	Family	The CADD, Chlamydia protein associating with death domains, crystal structure reveals a dimer of seven-helical bundles. Each bundle contains a di-iron centre adjacent to an internal cavity that forms an active site similar to that of methane mono-oxygenase hydrolase [1].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.40	0.72	-3.87	140	559	2012-10-02 21:56:19	2011-11-23 09:10:08	1	8	409	3	220	662	254	104.50	24	27.19	NEW	Lhp.....shhD.Eh.G.sGp.scp.h................HspLa.......tchhpshGlsss.h.........shhct..hs.s.....t.....sl.u.....hsNhh..hhuh.p.+.p.hh.sthlGths.s.hE....hsss..h....hpphsp....u.lc.R.h.G...h.stts...hpaas.Hlp	.....................hhpshh-.E.h.G.....sGp..pp.s.................HspLa.......tcllpshGls.s.h..............................thhpt.hs..s..........t........sh..t..........hs.shhh.hhsh.p.c.phh.sthlGhhh.uhE....hhss.t...hp.phsp....sLc.c...h.G.....h.s..t...htaashHlp...............................	0	52	127	189
+14370	PF14519	Macro_2		Macro-like domain	Coggill P	pcc	Jachmmer_A6ZME4, pdb_1njr	Domain	This domain is an ADP-ribose binding module.  It is found in a number of yeast proteins.	27.00	27.00	27.00	27.00	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.59	0.70	-11.93	0.70	-5.29	3	54	2012-10-02 00:07:53	2011-11-23 11:38:38	1	1	53	3	34	65	2	231.40	30	93.76	NEW	MTts.s++p.hN...phRIVLCDTNEVVssLW+KhlPKuLlpssKhVClHHGsLESLhcSMRKscspH..........sGcKYAIVSPGNSFGYLGGGFDLALaNYFGGKPFETWFRscLGNRYHTVGSATVIDLpRChLsch.EsRDGIRYIIHVPTVVAPS+PIFpcupPLKTGYEPVFNAMWNSLMHuP+DlDGLIIPGLCTGYAGVPP-ISCKSMAFALoLYMLsD+ISKEL+NlLIMYYLGYPFEPFFLESCpEECQtLGIDIEpLcSFNVE+DsI-tLIP++lLs..L	................................................................................................................hp...h................................spsh...uIVSPuNSaGahGGGFDhAlh.......p.........h.F..G.....s.....+....s..h...E......s...hhR..ppl..s......sc........Y.......t....s...l...GS.sTl..lcLt.......cth.t.p.............tptp.......sl+YllcsPThlsP...pts......has.p...tshps.shp.l.....Fs.s.hW...N....sl......h.........p.s....s.p.c.I-sLllPGLsTGauGVss.lus+pMsFAlpLah...h...t..........................................................................th..................................................................	0	6	17	29
+14371	PF14520	HHH_5		Helix-hairpin-helix domain	Bateman A	agb	Jackhmmer:C6UUJ1	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.31	0.72	-8.79	0.72	-3.80	554	12686	2012-10-03 02:11:09	2011-11-23 13:36:33	1	143	4845	77	3277	11596	4688	61.00	23	15.86	NEW	p..th..............h..p...t....L..h.......s...l.........sG........lG......s.p......hu.tt...l.............hpt..........ht...............................................o...l..p....p.l....t.p..............s......s.....h..c.p.........................................Lt....p....l....................G...............................l....u..p.c...pAppl...l.tph+.c	.............................................................................h....ppl..h......s......l.....sG........lG..sc......hs.tt...L...........................hsp........t..ht...............................................o....h..p....c.l....t.p......................h......s.....h..c..c...................................................Lh....p.....l...................................tG..................................l.....u..cc...sAppl...l..thc...........................................................................................................................................	0	1019	2066	2740
+14372	PF14521	Aspzincin_M35		Lysine-specific metallo-endopeptidase 	Coggill P	pcc	Pfam-B_2237 (release 26.0), pdb_1g12 	Domain	This is the catalytic region of aspzincins, a group of lysine-specific metallo-endopeptidases in the MEROPS:M35 family. They exhibit the following active-site architecture. The active site is composed of two helices and a loop region and includes the HExxH and GTxDxxYG motifs. In UniProt:P81054, His117, His121 and Asp130 coordinate to the catalytic zinc ligands. An electrostatically negative region composed of Asp154 and Glu157 attracts a positively charged Lys side chain of a substrate in a specific manner [4].	30.00	30.00	30.10	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-11.18	0.71	-3.69	34	226	2012-10-03 04:41:15	2011-11-23 14:29:17	1	8	116	9	119	217	3	142.80	27	48.57	NEW	u.Lpptsss..pp....apsWFGshssp...........+hsslhsphsshstsh.s..s..hthsCs......sst..s...sshthshPsph.tp..IhlsssFhs.hss.....sGhDSpsuTLlHEhSHFss.........shGTsDh..............sYs..pssupsLupssPspAlpNADshEhas-	..........................................................s..........t.p.....appWFGshssp...........+hspspst.hhphcpshts.tt..h...hhsss.........sp...s.......sthAhshssph.hp.....lal.ss.t.....Fhp.sss............oGp...-.S......+....suTLlHEhSHh.s...................ss..t..opDh..............sYu..ppssp.p....LApspP.spAlpNADsaphah..................	0	87	97	113
+14373	PF14522	Cytochrome_C7		Cytochrome c7	Eberhardt R	re3	Jackhmmer:Q74BP5	Family	This family includes cytochromes c7 and c7-type. In cytochromes c7 all three haems are bis-His co-ordinated. In c7-type the last haem is His-Met co-ordinated [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.26	0.72	-11.57	0.72	-4.34	198	1003	2012-10-01 23:37:15	2011-11-23 15:49:51	1	52	372	25	549	1372	400	72.40	23	23.15	NEW	shFsH.......ptHhp........th.....s..........Cs..sCH.sp................hh....sspt.....hshsph.......t..s............ptCss.CH..............sup.....pu..........................sssCs.pCHt	.................................FsHphHht............th..s..................Cp..sCHss.............................ht.....ttph....................hphssh...t..s..........ttChs.CH..................................stp............s......................hssssCs.pCH................................................	0	172	394	505
+14374	PF14523	Syntaxin_2		Syntaxin-like protein	Bateman A	agb	Jackhmmer:E7Q9M8.1	Domain	This domain includes syntaxin-like domains including from the Vam3p protein [1].	25.20	25.20	25.20	25.20	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.27	0.72	-3.99	91	588	2012-10-03 05:55:03	2011-11-24 17:46:35	1	10	286	1	374	673	2	97.20	24	35.43	NEW	luspl...hplsss....lsplp+hhpplG.Tt.....+Ds.clRcpl.c...........phhppssphhcphsptlpplsph.......................t.....pppphtppKLsp-FppslppapphQcp.htp+ppsts	....................................ustl.plsps........ssplpch.lspLG..Tt..........pDoscLRcpl.p...........phpppss.pls+cssptl+phsph..............................t.pppp+hppp+Lsp-FpssLppFQtsQ+pss-+p+t..h............................	0	100	169	281
+14375	PF14524	Wzt_C		Wzt C-terminal domain	Bateman A	agb	Jackhmmer:A8A1Q5.1	Domain	This domain is found at the C-terminus of the Wzt protein [1]. The crystal structure of C-Wzt(O9a) reveals a beta sandwich with an immunoglobulin-like topology that contains the O-antigenic polysaccharide binding pocket. This domain is often associated with  the ABC-transporter domain.	22.00	22.00	22.00	22.10	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.65	0.71	-4.49	236	837	2011-11-25 13:44:43	2011-11-25 13:44:43	1	9	707	2	260	731	162	141.70	17	33.12	NEW	thts.sttphGsspApI..pssplhs.tpGp.ssh...lpsG-plplplp..hph...ppslps.sl..hGhhl.+..sppG..h.lhG.sNohhpp....ttls..hht..........upphplpaphph...Lss..G.pYhlssul...................t..ptp...stp.hchhpcs.hhF...pVh.s..................spphhGlht.lss	............................................th........tpttspltpsplhs...tpsp..hp.h...lps.G-p.lplclp..hps....pps.lpp..sh..hGhtl..+.......s.ppG.........thlhG..sNo.hhps.......hplshh...........ssphphphphth....Lts..G.pYhlslul..................pppsth.h.chh.pp..s..hhh..pVhs..........p..h.Ghh.h.....................................................	0	95	178	225
+14376	PF14525	AraC_binding_2		AraC-binding-like domain	Bateman A	agb	Jackhmmer:D9V2D0	Domain	This domain is related to the AraC ligand binding domain Pfam:PF02311.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.88	0.71	-4.69	230	1819	2012-10-10 13:59:34	2011-11-25 14:10:04	1	6	746	0	600	1693	67	174.60	16	52.75	NEW	hcchluphhs...s......t..........clpst..s...ts..shp.....uphpthplGs..lslstlp......hs........sps......pl.....cs.sp............psh..hhlplslpGpuplp.ps.sp.pstsssup..sslhsssp.s.hp...h.p.hss.........ss.c.....plhlpls.............................c.......ph..ls.pshp.t...........sht.hs...sp.................hshs.sshu......thhtp.....hlptlhs.phsths.....s......hhpps.h..hspph...p.s.Llh.shLh	...........................................................phhsph.hs.s......h..........p..hps...s....tp...thp.....uphpt.ht.hss......lplspls........hs...............sth............tl.....ct..ss................sth..hhltl....l..sGps.t.h.p...p.s.....sp...ps.t.hs.sGc.....hslhcs..sp.s.hp...h.p..hpt................ss...c.....plsl..t.....lP.............................csh.Lp.phhs.t...........sh.h.hs...p.........................l...shs...sshs.......phhtp......h..lpplhp..phst.hs.............tt.t..t..htpth.....p.Llh..h..h......................................................................................................	0	118	310	451
+14377	PF14526	Cass2		Integron-associated effector binding protein	Punta M	mp13	CATH:3gk6A00	Domain	This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown [1] to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-11.05	0.71	-4.20	24	758	2012-10-02 11:08:51	2011-11-25 15:11:58	1	8	542	1	127	2424	50	145.20	18	79.49	NEW	clpchsuhslluhth..phppspt.....hptchsphapphh..p..pt....hsph.tpp...pchaulhts.t......psthshhsshssps......hsps.......hphhphPsupYhshps.p...uphs.p.lt.chatph.htth.ppp.psat........psss.s........p..hEhY........hpss................p....lElhIPV	...............................................................................................l.ph..thtlhuhtt.....hp.ptptt............tt.h.s..shapplh.....p.....ps...............hsp..l...t.t..........ssh.....a..u..l..a..p.......sh.t........hpsc.....h.s..h.........l.s.h..s..sps..........h...p.s....................hphh.p..l......s.s.c.Yhs.h.ss.p..........sphs..p..ls..p.....h..a...pth....hthh...p..p...ssht............hsss..s................s...hEhY............hpss........................s-lhlPl.......................................	0	51	88	110
+14378	PF14527	LAGLIDADG_WhiA		WhiA LAGLIDADG-like domain	Bateman A	agb	COG1481	Domain	This domain is found within the sporulation regulator WhiA.  It is a LAGLIDADG superfamily like domain [1-2].	23.20	5.00	23.20	5.00	23.10	4.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.06	0.72	-10.04	0.72	-4.12	23	1981	2012-10-03 01:41:40	2011-11-28 15:47:47	1	15	1950	3	344	1568	111	93.00	42	29.70	NEW	tpualRGsFLuuGSlscP.pss.YHLElssssp-hspplpcllp..ca.slsuKlhcR+spallYLKcuEpIschLpllGAppuhhcaEslRlh+-hR	.................t.+uYLRGAFLA.sGSlssP....-po..YpLEIho...h.p..-aA.psLspl.hp.......pa.tL.......s.....A.......K.s.......l.......E.......R.....+.......p.......u..........hls..Y...L....+..-...u........E.c.Is-FLslIGAhpu.hl.c.F.EclRIhR-hR............................................................	0	139	249	304
+14379	PF14528	LAGLIDADG_3		LAGLIDADG-like domain	Bateman A	agb	Jackhmmer:P21505	Domain	This domain is part of the LAGLIDADG superfamily [1].	22.50	22.50	22.50	22.50	22.40	22.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.61	0.72	-3.74	233	970	2012-10-03 01:41:40	2011-11-28 17:32:55	1	236	486	19	348	1219	203	81.20	21	10.86	NEW	t.sFLpGl....asuDG..sl.....p..t..pp................tlplss...s.sp....p........llc........plpp.l.L.h.p.hGIhu..plh.......t............c.......................p...................p....................psh...a..pLhI....su..cs..ht.pFhcpIG	....................h.taLpGhasuDG...sl.....p..t..ppt..................plphs.s......s.sp.....p........lhc........slpp.l.L.h.p.h.Gltu...plh...................p...........................p.....................p.............................................................psh...a.plhl....su..cs..h..tahp.l......................................................................................	2	97	192	286
+14380	PF14529	Exo_endo_phos_2		Endonuclease-reverse transcriptase 	Coggill P	pcc	CATH:1wduB00 	Domain	This domain represents the endonuclease region of retrotransposons from a range of bacteria, archaea and eukaryotes.\	\	These are enzymes largely from class EC:2.7.7.49.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-11.03	0.71	-4.49	204	2004	2012-10-02 01:25:08	2011-11-29 14:09:45	1	110	233	3	1603	5329	1737	121.10	19	18.41	NEW	lhlhusYhsPst.............hpphhpplpphhpphs.......hllsG.DFNu..........tp.hWuu................ss..........................pcGptL....hphhpptslthh............sp.s..pt.sTahstps..............t....Shl.....Dlshs...ssshhtt..................h...hh.....SDHphlh	...................................................hlhslYt..Pstt................................pth.h.pt.L.pt.h.hpph.........thllsG.DF.Ns...........................................................h.p.....s.....t.....hss...................tp.........................tp...............................................ppu..p...tl..........hp.h..h.p...p...t...s.L.t.h............................................................pt..t.....pt..hTahsspt...................tstl.....Dhhhs.sp.shhtt........................thh.t......hh.....................SDHp.l.............................................................................	0	649	1047	1503
+14381	PF14530	DUF4439		Domain of unknown function (DUF4439)	Eberhardt R	re3	Jackhmmer:Q7TXQ6	Domain	This domain has a ferritin-like fold.	25.00	25.00	25.30	25.40	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.59	0.71	-3.67	37	325	2012-10-01 21:25:29	2011-11-29 14:31:28	1	1	321	2	85	267	7	124.60	31	52.61	NEW	ALpsALAAEHAAlYuYGlluu+l.ssstpstApsuhstHRARRDslhthlpstGssPssstAuYtLPh......sVsssusAspLAuplEpcsAssatsll.tsssushRshAspALp-uAlRus+Wpusss......AFPGhsp	..............h.tsls.hEauslauh..ul..s..t....u....h.......ss......t.hp............sttshttH+spR-pltptlpst....usTsss..s..s..s..G...Y..tl.sh............s..ssssAuutpLhstl.Es.csssuWtsVs..tAssu..ssRshAlsuhspsAhhhs+httshs.........saPG.............................	0	28	64	81
+14382	PF14531	Kinase-like		Kinase-like	Eberhardt R	re3	Jackhmmer:B6KSS4	Family	This family includes the pseudokinases ROP2 and ROP8 from Toxoplasma gondii (Swiss:Q06AK3 and Swiss:O15693). These proteins have a typical bilobed protein kinase fold, but lack catalytic actvity [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.70	0.70	-5.45	8	140	2012-10-02 22:05:25	2011-11-30 11:55:51	1	3	7	6	79	15114	247	263.20	26	50.30	NEW	shpVsSpLGptsRsLl+sshlshschulhapssDpETsEshsl+Vhhhss.-sopp-l-ph+cpsLAlsL.hhul+NPppApsahRhlhPaDLVplssKshhhptpscppshhVhNhFhLhPsspssL.........phlschltppssp..ctsLsptARLhLTlQhIRLsAsLQscGlVHuchpssshhLcpcGGlaLssF..ssLsRsGs+ssh.upss....puauPPEhpup+tt..at..sssphTauhDAWsLGlsIahIWCtcLPhshsssthu.-a.............hFspCp.shP-sV+hLltphLphspcsR	...........................................................................................................................................................................s...........h..l.hhht.lt..t..hhh.spc.tp.p...htlh......h.....h............t....p.........s....st....tt...hpp.........hp...c.t...htht....h.........p...s....s.........A....p...h.....hR...hlh.....P.....D....h.l....tl....t........ps.........p..ht......t..ps.....h...h..l.......s..h.h..h..L..h..P..t.....h.....p..s...s...h.............................................tt.h..h..p....l.ht...h...ss.........p.p.t..h...s.h..h...s..+...h...h...L...T....h.....Q....h.l...+.L.........l...A...p...L......p....s........p....G....l....V.H.u..........c..lpP..p......s.h..h......l........t......p.......c........G...........t..........l...h......L...u....D......F............u.p.......l...h....+....s....G.......s....p..h..s........upss................................s....a......s.....P.......P..E.......h...h..s...p.......................................................p........p....s.........t......h......T......a..........u.....h......D.....A....WtL.Gl...s..l...a.h.l......W....C....t.c....h....P.....h......s......h....s......s......s......t......h......s.........p.h......................................F..s.....t....C.....t.....s........h.....P........-..........V......c.....t......Ll....pphL..phs.ppR....................................................................................................	0	57	58	79
+14383	PF14532	Sigma54_activ_2		Sigma-54 interaction domain	Eberhardt R	re3	Jackhmmer:D1EI59	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.45	0.71	-4.12	21	695	2012-10-05 12:31:09	2011-11-30 16:25:51	1	32	602	10	154	18102	4682	141.20	25	30.88	NEW	LGsSsslp-lpcpLEtsu..ppssPlLLsGEsGSshEhlA+al+psssP....Wlp.schppls...c...hP........h-...lLpp....A....sGGhLals-lsphuKshQpulhhlLs+.........u-.+hsl...Rllssuupshsp.htsssh-scLhphLSshslplPsL	....................................................................................lGpSthh.p.p.hppp.l...p...p.h.A........p...s......s......h........s......V...hl.h.GEsGo.G+pp.l....A....+.....h.....l...H.....p...h........u.s.p................tpt...s...hh...h..h..phs.......s........s...........................................tp.........h.lpp.........................u...........pG.GT..Lh.lsc..l..ctL..s..c.p...t...Qp..pL.s.phLpp.................................tc...cp...sh...........R.l..l...us.s..s...t.sht...p.......h..t.t.sph.t..t-La.h.hhs..s.pl.hs.L....................................................................................................	0	50	105	137
+14384	PF14533	USP7_C2		Ubiquitin-specific protease C-terminal	Coggill P	pcc	Pfam-B_1954 (release 25.0)	Family	This C-terminal domain on many long ubiquitin-specific proteases has no known function.	29.40	29.40	29.40	29.40	29.30	29.30	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.19	0.70	-11.44	0.70	-4.90	69	415	2011-12-01 14:48:45	2011-12-01 14:48:45	1	20	259	1	265	395	4	201.30	27	19.14	NEW	ptlaYElLs.hslsEL.Es++s...lKlhWlssshpc-.......p.hplhlsKsuTVpDllsclpc+hph.....s-ststclR..lh...Eh......tt.Khhchhs.p-psltsl...schh.t.............................hhhE...clPp-Ehpht.p..tt.....plltVhHFp+-ss......p.aGlPFhFhlppGEsFs-sKcRlpc+h..slss.KpFp.KhKFAl.lphsph..........pYlpD..cc..ll.shhhptc..........p..LG.LDH.scss+p	............................................hlaYphLs.hsls-h.-sp+s.............hKlhah........p.sshpc.............phplhlsKpusltDllpclppp.spl...........scpt...stclR..lh............-l.....hsp..Klhplht..tcph..lpsl....sct..p..............................................hhhE....clPp-c.hshs....t-..............................hllsVh...H..Fp+-st..........psaGhPFhhhl+p..uE..phtcs+cRlpp+h....tltp.cpFp.K..hKFAl.l..hsp...................pYlp-..st...l..h..p.p................p.hLG.L-H.sps............................................................	0	84	139	212
+14385	PF14534	DUF4440		Domain of unknown function (DUF4440)	Eberhardt R	re3	Jackhmmer:Q11v67	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-10.37	0.72	-3.83	216	1968	2012-10-03 02:27:24	2011-12-01 15:55:36	1	41	1054	19	759	4175	1032	109.10	15	69.00	NEW	lhphcp.p...hh.p.u.h.....s.p..sD.hs...th.tpl...h..s.......s.-.h..hhh.....sss........Gth..h..s.........+pp..hlpth.........tp.......sh...h.t..h..t.ph.....ph.ps.......hp.l..p......hh...ss...sA.hlt....sp.hp.h.......pt...pt..s.....s...t.h.t.......tphth.splW.p+.p....ss..pWpl	...........................................................................h.tth...p.u.h.....s...p.....s-..hp....sl..tsh.....h..s...............s..-..h.....hh.l.........sss................Gth..h...s...........ppp....hh.pth...............ps.........tt.....h..p...t...t.sh........ph..ps..........hp..l...p........hh.....sc......sA....l..lp....hp..hp..h............ph.......ts...s..................s.....t.h..t............hp.st.h.stlap+.p.....ss....tWth................................................................................	0	280	490	656
+14386	PF14535	AMP-binding_C_2		AMP-binding enzyme C-terminal domain	Eberhardt R	re3	Jackhmmer:A6L0Y5	Domain	This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.06	0.72	-3.94	244	1758	2012-10-03 01:00:17	2011-12-02 13:31:06	1	7	1084	15	662	1569	228	94.80	32	21.53	NEW	GVNlFPoQIEplLhph.stlu.scYplllsR.p..s..s..hDplplpVEhsp..t.h.s.c.ph.............tp......hpp......lpcclpcpl+sh.lGl...s...s...cVclVpPtolsR.....S.E.G...K..A+RVlDpR	.......GVNVFPoQIEcllhp..h..t.t.l.s....s..c..Y..plh.l...s+.c......s...p......hD.p..lplp.VEhpp..th..s...p.................tp........hpp......lpcpltccl+sh.lGl.s...s...c.....Vpl.lpss....olsR.....o.p.G.....K..ApRVhDhR............	0	235	477	589
+14387	PF14536	DUF4441		Domain of unknown function (DUF4441)	Coggill P	pcc	Pfam-B_1275 (release 25.0)	Family	This family is largely made up of uncharacterised proteins from the Ciliophora.  The function is not known.	22.40	22.40	22.50	22.40	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.73	0.71	-4.12	66	94	2011-12-02 16:40:58	2011-12-02 16:40:58	1	2	2	0	94	142	0	118.40	24	42.38	NEW	pNh.hKNI.l+uF...tpalh...............pppcp.....................................hlhphhpph.........tpp.p.......hpphp..Kphppahcppshs.N.p.....lppllpsppaspl.FpaaLpptsptWL.ppS+lpstppahhhIphlhpshpst..phlpplpha.K	................................................................................................pNhhKNI.lpuF....hpalh...............pppc.p...............................................hlhphhpph.........t...p.......hpphp..Kphpphhp.ppshs.Ntp......lppLlppppapph.FpaaLptpsptWL.ppSKlpspppahhhIphlhpshpst..phhs.lphhp...............	0	94	94	94
+14388	PF14537	Cytochrom_c3_2		Cytochrome c3	Eberhardt R	re3	Jackhmmer:Q8EDL6	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.81	0.72	-11.87	0.72	-3.64	85	1009	2012-10-01 23:37:15	2011-12-07 10:41:39	1	39	603	40	274	1023	144	93.50	36	38.08	NEW	hHtptu.hsCt.sCH.......s...sst..ttst....s.hpspp................ClsCHs...sh.p.....ph......sp.ptt......................s.Hs.......sH..........spls.CssCHps.Hp...........ts.........hC.s.s.CHs	..................................th....hslsCs.sCH.................u.....pss....spp...cp.......ulcssh......................................Ch..S..CHh..sp.p....h.......pc..s.............................................hhPH.c.........sH...s.........scls.Cs.uCHu.h..Hs....................................c.tt.....phCs.s.CHs.......................................	0	87	186	233
+14389	PF14538	Raptor_N		Raptor N-terminal CASPase like domain	Bateman A	agb	Jackhmmer:F5H7J5	Domain	This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure [1]. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.	27.00	27.00	27.00	34.30	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.82	0.71	-4.37	48	343	2012-10-03 02:24:44	2011-12-08 19:24:50	1	25	255	0	246	365	5	148.00	52	11.29	NEW	+hKTsslsLllCLNIGlDPPD....lhKssPsA+hE....CW.....lDPps....hs..........t..KulcsI.upsLppQYcph..p.+.....s+a+.tlDPol--l++hCtshR+sA+s...-RlLFHYNGH..GVP+.PTssG.....EIWlFN+saTQYIPlslh-LpsWlssPslaVaDCSsAGhllpsFp	......................................................hKTsosALslCLNlGVDPPD....llKssPsA.+lE....sW.........lDPhs....hss.............p..KAlEpI.GpsLQpQYEph...p.R...............sRYKptLDPoV--lK+hCtoLRRsAKc....ERVLFHYNGH..GVP+.PTssG.....EIWVFNK.......sY..........T.......QYIPlSlYDLQoWluuPoIaVaDCSsAG.IlpsFp.......................................................	0	98	147	214
+14390	PF14539	DUF4442		Domain of unknown function (DUF4442)	Eberhardt R	re3	Jackhmmer:Q9I2R0	Domain	This family of proteins is found in bacteria, archaea and eukaryotes.  Proteins in this family are typically between 139 and 165 amino acids in length.  There is a conserved PYF sequence motif. There is a single completely conserved residue N that may be functionally important.	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.48	0.71	-4.17	66	935	2012-10-02 20:54:35	2011-12-09 10:57:25	1	2	624	4	278	1704	374	137.40	21	84.79	NEW	GptlFStshsh+APYFuT.lpPplpcLcPs..hsplpl.c++tVpNHIGTlHAIAhCNhAEhAhGhhsEAolPs...stRWIPKGMsVpYlAK.AposlpAsAphs.s..........sa............pp.....s..s.-...lsVsVplh...D.psG.hp.V.spupIsh.WV	.....................................................h......hhht.hhP.h.h...hs.sshcl..hplsss.....pscl.pl..hp..h.ts.c.N.a...l...s..o.....h..auGulh.shs-.s....s.hG..h...h....h..h...t....plsp.............chh...h..h...s...K..u..hplc..a...l.+.........u..c...u..s...l.p.Ap.spls.p..........tph............tp.....p...tt...h.h.......l...p....lh....-..pp.G...ph...l..spsphph.h.............................................................................	0	97	182	244
+14391	PF14540	NTF-like		Nucleotidyltransferase-like	Coggill P	pcc	CATH:3c18A01	Domain	Structural comparisons with PDB:1kny indicate that this N-terminal domain resembles a nucleotidyltransferase fold.	27.00	27.00	38.40	37.70	22.10	21.20	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.33	0.71	-10.24	0.71	-4.50	23	78	2011-12-09 13:30:00	2011-12-09 13:30:00	1	1	78	3	27	80	0	118.80	40	40.16	NEW	MEslLRPIYQE+ASpssTLGllhlE++..pppsslTDsFDslLLVIscc.sEpshalKHYphssc+suL+lVs-cpLpcWllhGoNR+llDWlhpG+llFDRNEYlppL+pcLppFP.ppRc	.............M-slLRPIYQE+AScssTLullhIE+c..ppp..uulTDsFDslLLVIVcp.s-pshalKHYphcpc+AuLahVo-ppLpEWlLlGosR+lIDWllpG+llFDRNEYlppL+pcLppFPhtpRc.....	0	7	18	21
+14392	PF14541	TAXi_C		Xylanase inhibitor C-terminal	Coggill P	pcc	CATH:1t6eX02	Domain	The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylasnase.  Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.	21.90	21.90	21.90	21.90	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.92	0.71	-4.69	112	1552	2012-10-02 15:32:34	2011-12-09 14:54:42	1	19	111	13	878	2503	14	147.00	24	35.70	NEW	tYalsl.puIpls.....sppl.s.lss.shh.........u...tGGshlsosssaThLtsslYpsltpAFsp.thst........h.p.ssssssFchCassss.h........tt..hshslP.sl.sLhhpu.....us.....phpl.us.shhlp.s..s...s.s.........sh.CLuFlss.................sstssslIGuhQhpsphl.FDltssplGFss	...................................................................Yhlsl.pu..IpVu.................sphl..s....l..ss...shh...............s..........suG..sllDS.GTs.hThLs....sss.Ypslppsh.tp...t..hst......................ss.s..h...s.s..h....c..h.C...ashss.........................ttstlP.s.....l.slpFps...........Gu.......shpl.s.s.p..sh..hh.t..s..s......s.s...........................hh..C.L...u.hsss...................................ttshsllG...sh...pQpshh.lhaD..ltpp.plGFt.....................................	0	106	490	698
+14393	PF14542	Acetyltransf_CG		GCN5-related N-acetyl-transferase	Coggill P	pcc	CATH:1xmtA00	Domain	This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterised by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site.  It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.46	0.72	-4.09	355	2309	2012-10-02 22:59:21	2011-12-09 16:30:00	1	16	1990	7	555	1626	130	78.60	29	78.76	NEW	Ratlth.s............t...uhh...sY..................pt...............sst.........hh.slsHThVssshcGpGlAspLlctulctsRppGh.+llPhCsalt.s.ah..c++P.-.a.p-l	..................................pa.lts-......Gpth..u.l...s.Y.............pp....................sss......hhhlsH.T.hVscshcGpGlupp.Llct.sl-psRc.p.s.....h.Kl...l..PhCsasp.phh..c+ps..-..a.p-l.................	0	176	360	478
+14394	PF14543	TAXi_N		Xylanase inhibitor N-terminal	Coggill P	pcc	CATH:1t6eX01	Domain	The N- and C-termini of the members of this family are jointly necessary for creating the catalytic pocket necessary for cleaving xylanase.\	      Phytopathogens produce xylanase that destroys plant cells, so its destruction through proteolysis is vital for plant-survival.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.35	0.71	-4.29	111	1620	2012-10-02 15:32:34	2011-12-09 16:34:32	1	20	98	13	922	3319	9	167.20	27	38.32	NEW	YshplphGs............P...........h.hslDhu.ushhW.hpC....................................t...Ssoa....psl.C...........sSs.Ct.ht......................sssts..ssCthhs..s.....stsssG..pl.spDsl.hssst.t..................sshsshhFuC......ussth..............uh.t...........................sssGlhGLu.pst...hSLsuQlutt.....hsp+FuhCLss..............ssssGhlhFGs	..........................................YhhplslGT..P.sp.........hhlhlD.TG.S-lsW...l...p..Cpss.................................................................tshtt..shas.PspS.ooh..........ptlsC.................ss..s..h..Cptht.....................................tsss.s.s.s....s.C...s.....Y.p...h..p......Yus.......sosotG.......hl..spDslslsss...........................ssh.s.s.hsFG.C........upssp.............Ghht....................................sssG.l...lGLG....pus...................hS.......l.......s......o......Q......l...tt................hsstFSaC.Lss.................sssuhlhhG.............................................................................................	0	113	501	731
+14395	PF14544	DUF4443		Domain of unknown function (DUF4443)	Coggill P	pcc	CATH:2p8tA02	Domain	This is a family of archaeal proteins. The domain is a putative gyrase domain.	18.50	18.50	18.60	19.00	18.40	18.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.59	0.72	-4.16	8	29	2011-12-09 16:41:01	2011-12-09 16:41:01	1	1	29	1	20	33	3	105.00	30	52.94	NEW	FS.EsttV.u.VEGaPAYAIVVKNPPpFKSIELRDEAIRFFAKGAMILlVKNGElVFPEDtRPL+EThPELAE+L...l+h..--...GDhlVVTWAENPuDAhKSAhHVALsLKp-EI	.........................................hulhhtt.sp.h.c.u..l...-LRDEAIRasAcGAhIlhhKsGcllFP..E..DtcsL....c-hhs..cls..ccl...tph....c-...GDhlllThu-s.spAhpuhh...............................	0	4	5	13
+14396	PF14545	DBB	BCAP_N;	Dof, BCAP, and BANK (DBB) motif,	Coggill P	pcc	PROSITE, Pfam-B_2980 (release 26.0)	Domain	The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerisation. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions [1]. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling [2].	22.20	22.20	22.90	22.20	21.80	21.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.82	0.71	-4.67	13	113	2011-12-12 13:27:38	2011-12-12 13:27:38	1	1	63	0	61	137	0	136.40	37	17.33	NEW	FsVtP+Kl+sGps.+VhllLsp...sLpccsslpVphcpssps.....lssscpcNPYTlphssP-thhplSthVslplcpsshsLGs+slKCcScLcElpplLps...sssPlEFMCQulsIsPsspEpLDplLhpoFp+.NlPss.apLhu	.........sV.Pc+lpCGpptplalIl+s.....cLpcpso.sElEFpspsp.hh...phpsphcNcYTlshpAP-h...suGsVslplYssslslupssIpYYoshcElpplLpp...sssPlEFhCQAhtlsshspEsLDplLTpshKc.NlPssthpLht......	0	12	16	33
+14398	PF14547	Hydrophob_seed		Hydrophobic seed protein	Eberhardt R	re3	Jackhmmer:Q9S7Z9	Domain	This domain has a four-helix bundle structure. It contains four disulfide bonds, of which three function to keep the C- and N-terminal parts of the molecule in place [1].	23.40	23.40	23.40	23.50	23.20	23.30	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.24	0.72	-10.80	0.72	-4.08	24	532	2012-10-01 19:46:35	2011-12-12 14:20:06	1	8	71	0	253	530	0	81.10	49	49.60	NEW	sCPhssl.cLssCssVL.slhplhlGs..tsptCCsLltGLssl-AAsCLCssl+hplLs.lsl.lsl..slplllshCG.+s..PsGFpCs	................................pCPh..Ds.L..KLusCuslL..G.............L.l.p.lt.lG..s..........s...s......spsCCsLlpG.LsDL..-.AAl.CLCT.AlKAsl.L.G.......Isls.l.Pl..sLs.LLLNhCG.Kps....PsGFpCs....................	0	18	110	191
+14400	PF14549	P22_Cro		DNA-binding transcriptional regulator Cro	Coggill P	pcc	CATH:1rzsA00	Domain	Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth.  It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.62	0.72	-4.25	33	735	2012-10-04 14:01:12	2011-12-12 15:55:30	1	3	468	8	62	374	11	58.40	33	75.46	NEW	pKsDllpaFGuts+lApALGlopsAVSpW....G-hlPEhRAaplEclTsGpLKss...sslhpcss	.............h...cslsaa.G.o.ps.KlApAhG..ls..suV.spW.....sch..lPc.......t.......R.......Ah.plppsou.Gtlphp...........p...........................	0	11	27	42
+14401	PF14550	Peptidase_U35_2		Putative phage protease XkdF	Coggill P	pcc	Pfam-B_5816 (release 26.0)	Family	This domain is largely found on phage proteins.  In a number of cases the domain is associated with a SAM-dependent methyltransferase.	24.00	24.00	24.60	29.60	23.90	21.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.75	0.71	-4.50	35	118	2012-10-01 19:43:34	2011-12-20 15:14:30	1	3	106	0	21	108	166	123.60	35	38.81	NEW	hppplclh+........psp....--cplVaGlVhpPs......hhDucGDh....hss-EIEKAAapFhcp.....hpplDtpHch...psusuplVESaIsss.DhplsG...p..slp+GoWlhss+s...sD..p-lW-p....l+cG..choGaSluG...sAcph-h	...............tppVclh.ppsp....--p+lVaGlVhEPc......s.DuHGDa....hoA--IEKAAasFhpp.....hpplDhpHsh...psusupVVESalsPs..Dhplss.....p.plpKGoWlhss+ssD......-lW-p....lKcG..clTGaShuG...sAch..h...........	0	10	15	18
+14402	PF14551	MCM_N		MCM N-terminal domain	Bateman A	agb	Jackhmmer:O27798	Family	This family contains the N-terminal region of MCM proteins.  This region is composed of three structural domains. Firstly a four helical bundle, secondly a zinc binding motif and thirdly an OB-like fold [1].	24.90	24.90	25.00	24.90	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.38	0.71	-3.62	340	2275	2011-12-20 15:49:09	2011-12-20 15:49:09	1	42	484	10	1550	2224	62	132.50	20	16.40	NEW	hpcpF.ppFlpp...............ht..................................................................hYhpp................lpphhpp....p...p.........................................psL.lchp.cLtp..a..s..................................p....................pL.sp.t.lhppPtchl.s..hhcp.ulpchh.t.............................................................................h.spht...pc......tp......h.plphhsh............sp.............thslRsL.c..us..clspLlslpG	.................................................................................h..ptFppFLpp........apt................................................................phhY.hpp..........................lp.phhph......pp...........................................psL.Vsh.p.c.L.tp..a..s.......................................p.......................pL.sp.t.lhppPtchl.s..hhpp....Al...pchhhp.............................................................................hsstht..tp........pp......h.plp..hhsh.................sp...............hhslRsL..p..ss..plspLlslpG........................................................................................................................	0	540	876	1300
+14403	PF14552	Tautomerase_2		Tautomerase enzyme	Coggill P	pcc	CATH:3c6vA00, Pfam-B_819 (release 26.0)	Domain	\N	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.50	0.72	-3.96	157	646	2012-10-01 20:38:22	2011-12-20 16:17:50	1	4	541	17	193	1070	117	79.40	31	61.58	NEW	D+Fpllppa..csschhhs..sp.h..ls....sRocshllIpIssttsRohEpKptLYctlscpLpppsGlpspDlhlslsEsst.-sWSFG	...............................Dpaphhppa..p..s..pphhasst.h..Ls...hpRo.-s..h.lhlpIssttsRohcpKcpLYptlsppL.pppsGlpspDlhIolhEss.t.-sWSFG.......	0	42	99	150
+14404	PF14553	YqbF		YqbF, hypothetical protein domain	Coggill P	pcc	CATH:2hjqA01	Domain	This N-terminal domain is found in Bacillus and related spp. The function is not known.	27.00	27.00	33.20	33.00	26.40	17.80	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.51	0.72	-7.93	0.72	-4.29	9	66	2011-12-20 16:42:37	2011-12-20 16:42:37	1	1	59	1	3	36	0	40.30	59	71.20	NEW	ltGpTYsshGp..hFhhs.EppVscchapYLpsNcaFplpc-.sp	..IpGpoahAas+..+FLhupEEcVSEKlYNYLRRNEFFEVRKEE..a...	0	1	2	2
+14405	PF14554	VEGF_C		VEGF heparin-binding domain	Bateman A	agb	Jackhmmer:B4YYD6	Domain	This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.	27.00	27.00	51.00	51.00	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.92	0.72	-4.16	5	153	2011-12-20 16:57:28	2011-12-20 16:57:28	1	2	59	5	32	137	0	54.20	78	25.52	NEW	cpcENpCEPC....SERRKRLFVQDPtTCKCSCKaTDucCKSRQLELNERTCRCDKPRR	................t...ps.CtPC....SER..RKHLFVQDPQTCKCSCKsTDSRCKuRQLELNERTCRCDKPRR......	0	2	5	13
+14406	PF14555	UBA_4		UBA-like domain	Bateman A	agb	Jackhmmer:A2AT02.1	Domain	\N	21.80	21.80	21.80	21.90	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.83	0.72	-7.92	0.72	-4.42	201	1716	2012-10-01 23:03:33	2011-12-20 17:19:24	1	62	362	9	1068	1687	15	41.70	26	10.41	NEW	cphlspFh.slT.G..s....sp.....ppAppaLctssWsLctAlstaappspss	...................thlppFh.slT.G...s.....sp......stAtphLptssW..sL....p....tAlstaapt..............	0	328	522	821
+14407	PF14556	AF2331-like		AF2331-like	Coggill P	pcc	CATH:2fdoA00	Domain	AF2331-like is a 11-kDa orphan protein of unknown function from Archaeoglobus fulgidus. The structure consists of an alpha + beta fold formed by an unusual homodimer, where the two core beta-sheets are interdigitated, containing strands alternating from both subunits. AF2331 contains multiple negatively charged surface clusters and is located on the same operon as the basic protein AF2330. It is suggested that AF2331 and AF2330 may form a charge-stabilized complex in vivo, though the role of the negatively charged surface clusters is not clear.	150.00	150.00	155.20	155.10	29.70	17.80	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.18	0.72	-3.64	3	3	2011-12-20 17:20:05	2011-12-20 17:20:05	1	1	3	2	3	3	0	93.30	46	100.00	NEW	MPTYVFsKESFLKFLEKNLtEDsVVVVSSDVTDlDccpuESa.LGcK-aahVcFAlsADVFKEsDlDEFDEhhKYsVVFVESDEL.SEAG+KA.hR	MPTYVFsKESFLKFLEKNLtEDsVVVVSSDVTDlDccpuESa.LGcK-aahVcFAlsADVFKEsDlDEFDEhhKYsVVFVESDEL.SEAG+KAhR...	0	1	3	3
+14408	PF14557	AphA_like		Putative AphA-like transcriptional regulator	Coggill P	pcc	CATH:2rkhA02	Domain	Members of this family are putative transcriptional regulators that appear to be related to the Pfam:PF03551 family. This family includes AphA-like members.	27.00	27.00	27.10	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.72	5	13	2012-10-04 14:01:12	2011-12-20 17:41:38	1	1	12	0	5	54	17	175.10	40	93.05	NEW	asDNoLTPKEAVRLsALG.hIARuPhRYuDLAuAVRHFloRIsGPSLDLhGoSlELLRaEGLlEPlsGcGMEDNApLuIT-uGRpELpcLlTAsLRAu.SD.LuKLVIuLKLRFLDLLsscsRpcQIDsLLchsEoELARLsDL.RAAhuu-Gs..Lht-WLDp-IsQlEpRLuWLcuLt	.................................................atDNoLsP+EA.VRLssLG.hlAcuPt.R.Yu-LAu.u.V..RH.FhoRIhGPS.LD.LhG...oSlEhLR.aEGLl..E...shs...G..p..G.M.E...Ds.Ah..L.uIT-uGRpEhpsLh.sAslRss.oD.Lu+LVluLKlR....FLDLLss-pppsQl-tL..l-hsETELARLhDL.RA..A.s...s.s..s.G.s........hht-WLDp-I..sQsEpRLuWLcsL.h....................................................	0	3	4	4
+14409	PF14558	TRP_N		ML-like domain	Bateman A	agb	PF06011	Domain	This domain is distantly similar to Pfam:PF02221 and conserves its pattern of conserved cysteines. This suggests that this domain may be involved in lipid binding.	27.00	27.00	27.10	27.00	26.90	25.90	hmmbuild  -o /dev/null HMM SEED	142	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.92	0.71	-4.16	62	432	2012-10-01 19:31:57	2011-12-21 11:00:42	1	8	131	0	325	430	0	145.30	28	17.73	NEW	chlposulssCh-s.Sphsss...............hFclpasssspolsaslsus......................................oslssp.VssplplhAYGhplh.scshc.Cs..hs..ht........tlCPlssGphsspus.hh..sp..phsspIP...uI.AYslPDLDApl.+lhlhsss........sspplAClpusloNGKTsp	.................................t.ltosuhssC.....hss.Sthsss...............hFslsass..s..s..p.o..lphslsus.....................................................................................os.hssp..lshplplhAYGhphh.sp.s.hc..Cs.....hs.....hp............slCPls.sG.p......hshpss.hl.....sp.....sh.sspIP...................uI.AYslPDl-Aps+lhl.tssp.............sspplAClpuploNG+Ts.....................................	0	61	158	265
+14410	PF14559	TPR_19		Tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q87RI8	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.06	0.72	-3.63	300	8943	2012-10-11 20:01:04	2011-12-21 11:26:45	1	1648	2991	20	2662	21075	6378	65.60	19	13.54	NEW	hltpu.....chspA....hplhpp...s.h....pt.....psp....sspsth..t.....L..Acshlpt.sphcp...ApplLsplstppps....sphp..sl...hApl	.................................................tps....chspA.........hphhcp.......s.h........pt...................pPp..........ssphtl.......t....................L.....Apsh.hpt.G...c.......hpc...........Ap.p...hL...pp..hhtpp.s............................h...................................	0	874	1638	2192
+14411	PF14560	Ubiquitin_2		Ubiquitin-like domain	Bateman A	agb	Jackhmmer:1t0y	Domain	This entry contains ubiquitin-like domains [1-2].	23.10	10.00	23.10	10.00	23.00	9.90	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.81	0.72	-3.73	85	602	2012-10-03 10:59:06	2011-12-21 11:57:51	1	38	292	5	409	5698	192	79.70	20	19.48	NEW	sVplplTpstsp..htsE...tRashshTlpplKpKLphhsGsssssMpLpL..h.spssphlssl..........s-..DsthLGtYs.lcDGhclHVlDpsPss	..................................................c...h+.ls.shTl.....sp........lKp+Lphl.sGl..ss.sshcL..h....h....t..p..s...s..t...h...tph.......................cp....sp.phLst..as.lps....s.....plhl.......t...............................................	0	159	216	322
+14412	PF14561	TPR_20		Tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q87RI8	Domain	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.76	0.72	-3.87	216	1831	2012-10-11 20:01:04	2011-12-22 16:10:40	1	21	1796	5	436	1379	539	89.00	34	30.03	NEW	pussss-lppLctpls...ssPsDh..pAphpLAhthhtsGch--AlcpLlpll++Dpsh........s-ssARppLlclFpslGss...DPhssphRR+LsolLa	..............................tssss-ltpLppplA....t.sPp.Dh..phthpLAh.th.htsG+s.E-Al-hLhshl++.D.h..st.................................s-...sp.sR+phh-lhsslGss.............Ds.lssphRRpLhulLa..............................................	0	116	257	352
+14413	PF14562	Endonuc_BglI		Restriction endonuclease BglI	Eberhardt R	re3	Jackhmmer:O68557	Domain	This restriction endonuclease binds DNA as a dimer. BglI recognises and cleaves the interrupted DNA sequence GCCNNNNNGGC and cleaves between the fourth and fifth unspecified base pair to produce 3' overhanging ends [1].	25.00	25.00	25.10	25.30	24.80	20.90	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.80	0.70	-5.56	3	4	2012-10-11 20:44:47	2011-12-23 09:30:11	1	1	4	1	2	6	2	287.50	47	97.46	NEW	RpclapSYppsRsYLlsNh-pLIclEpYsLsllsNlI+-NtEEI+ADYNE.AsaLaPFWpNYPPE-RGRtP+GDQIPWLEVGEKsVGSKLsRLVsp+hE.sVR-lGLPTGuDlRallos.pI.plTNshTDSsalFlDIKSVGPRDsDs-lVlSPNQVSGsG-.W-sFpsGIpNNphTI..pGsRu.NasFhPoLPPLYILSDGpIVPVVplaIKPVYuMlSLp.psDGGQPLp+IclASVPNGLLLFsNPsYuaspAacsLFpPGKDEhTKDsppRRlRVcLclLuRIusWRshcIDp	........................Rpcla.SYpps+pYL.sN.-...clEhYsLsllsplIp-NtEEI+ADYNE.AsaLaPFWhNYPP.-RG+hP+GDQIPWlEVGEKsVGSKLsRLVsp+.-.sVR-lGLPTGsD.Rallos.pI.plTNshTDShhhFlDIKSVGPRDsD.-lVlSPNQVSGsG-.WsthpsGIpNNp.TI..pGsRu..sp.FhPolPPLYILSDGpIsPVVplaIKPlYuMhSLp.psDsGQsLh+IclASVPNGLhLFsNPsYuaspAachLFpPGKD-hTKs.hp+RlRVcLclLs+Ius.RshpIDh..	0	0	0	1
+14414	PF14563	DUF4444		Domain of unknown function (DUF4444)	Eberhardt R	re3	Jackhmmer:Q1GJN9	Family	This domain family is found in bacteria, and is approximately 40 amino acids in length. There is a conserved LIPL sequence motif. There are two completely conserved G residues that may be functionally important.	25.00	25.00	42.90	42.20	24.00	23.30	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-8.06	0.72	-4.57	20	30	2011-12-23 10:42:36	2011-12-23 10:42:36	1	1	30	1	4	32	8	42.20	56	19.81	NEW	lGE-lThsG.....tTGTFlGVDEcFGMLLRsss.sTHLIPLTolLEs	.......lGEplThsG.....tTGTFLGVDEcFGMLLR-ss.sTHLIPLToLLEp.	0	0	3	3
+14415	PF14564	Membrane_bind		Membrane binding	Eberhardt R	re3	pdb_1yhp	Domain	This family includes the C-terminal domain of Dictyostelium discoideum Calcium-dependent cell adhesion molecule 1 (Swiss:P54657), which has an immunoglobulin-like fold. It tethers the protein to the cell membrane [1].	25.00	25.00	28.70	75.60	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.99	0.72	-10.42	0.72	-3.88	26	35	2012-01-03 14:41:10	2012-01-03 14:41:10	1	3	21	2	25	36	0	112.10	26	45.68	NEW	slsl+lh....sssssstpYphslpsapls...ssshposs-...Yshlslhshs..sspllsplsl+sppt.....GthlssGSlYF+Yssssuplshsc.s...psaPp..sLclppsspspFshsLhs	..........lsl+hh...sssssssppYphslpshpls...ssslhSsss....Yshlslh.hs..ssplVsplslR-pph.....GthlssGSlYF+Ysssssplshsc.s...-saPp..slclpcsspssFslsLh....	0	11	19	23
+14416	PF14565	IL22		Interleukin 22 IL-10-related T-cell-derived-inducible factor	Coggill P	pcc	Jackhmmer:Q9GZX6	Domain	Interleukin-22 is distantly related to interleukin (IL)-10, and is produced by activated T cells. IL-22 is a ligand for CRF2-4, a member of the class II cytokine receptor family.	30.00	30.00	30.00	30.00	29.90	29.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.90	0.71	-4.10	5	53	2012-10-02 01:28:15	2012-01-04 14:53:14	1	1	36	14	29	136	0	136.60	54	77.25	NEW	CRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNAC	...................................C+LcpSsFQpPYIsNRTFhLAcEASLADNsTDVRLIGcc.LF+G..V...s.h.s-RCYLMKQVLNFTLEEVL.......h...P.......p..S..D+...F.....p..PY....Mp....-V...V....s....F....L....u....+.....L.Ss+LSp..CHIp.G...D-...pH......I...Q+...N...VppLK-T.VKKL.G.E.s.G-.IKAIGELDLLFhsL+sAC...	0	1	2	6
+14417	PF14566	PTPlike_phytase		Inositol hexakisphosphate	Coggill P	pcc	Pfam-B_194 (release 26.0)	Domain	Inositol hexakisphosphate, often called phytate, is found in abundance in seeds and acting as an inorganic phosphate reservoir. Phytases are phosphatases that hydrolyze phytate to less-phosphorylated myo-inositol derivatives and inorganic phosphate. The active-site sequence (HCXXGXGR) of the phytase identified from the gut micro-organism Selenomonas ruminantium forms a loop (P loop) at the base of a substrate binding pocket that is characteristic of protein tyrosine phosphatases (PTPs). The depth of this pocket is an important determinant of the substrate specificity of PTPs. In humans this enzyme is thought to aid bone mineralization and salvage the inositol moiety prior to apoptosis [3].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.84	0.71	-4.16	103	540	2012-10-02 20:12:17	2012-01-04 15:56:02	1	4	197	33	220	698	17	143.50	25	39.58	NEW	lsLREEshs...............asNst....hshct...hps.tpp..l.t..hpuhsstplpphEpth+pclhtps........pphssphhh.................................t...................................................................hc.p.thspshslpYhRlPlTDcpsPpspslDthlphlcsh.sp..................sshlhFpCptGpGRTTohMlhhsllp	........................................................................................................lsLREEshs.................ahs.Gts....hoh+phps.hps...h.........h.shstppl-...phEt........tl.+pclhtps........pphtsthhhhpp.pph..........................ph.tl..............................................................hhc.p...hs..p..th..sh.p.Y..hRlPloD.p.p....t.P.p.p.pshDthlphlcph..sp.....................................................sshhhFpCpsGpGRTohhhshhshh...........................	0	90	144	182
+14418	PF14567	SUKH_5		SMI1-KNR4 cell-wall	Coggill P	pcc	Pfam-B_7167 (release 26.0)	Domain	Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	27.00	27.00	27.00	27.10	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.37	0.71	-4.70	27	120	2012-10-01 20:46:44	2012-01-04 16:35:07	1	2	109	1	35	225	9	129.90	51	92.78	NEW	Mc-lI-pLpphspssslsl-LPsp-pls-lEcplhlslPt-aKcaLhpsSDllhGslEPlolsDs.oHoY..LsEsss.Ahs.hGlP+-hlPI.CpssssaYCls.....p-Gp........VhhWs..cG...s-EpWtshapWsccVWl	......................Mc-lIEpL+E.hsE.sVPV..PL.EL.P.-.-.-pLVElEEpLhIslPhpaKEFLLps..SD.V.........lY.....Gs.l.............EPVT..lo......D..Pp.SHTY...........LPEV...su..pA.W-...lG..l.PR.-lIPl.Cp.-..G..csYYCl-........pDGp.............VhlWs...-s-l..o--sW-SlWpWscDVWL......................................................................	0	3	8	24
+14419	PF14568	SUKH_6		SMI1-KNR4 cell-wall	Coggill P	pcc	Pfam-B_725 (releawse 26.0)	Domain	Members of this family are related to the SMI1/KNR4-like or SUKH superfamily of proteins.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.35	0.71	-10.69	0.71	-3.63	86	516	2012-10-01 20:46:44	2012-01-04 16:50:21	1	4	281	2	92	1001	10	112.20	18	72.41	NEW	ccpIpcsEppLul.....phPpsYKpFLcpYGu.ut.......hsGh-lhu.....h.................tsshhhtshh.t.ptthpp.htl.p.h.........llhpsssGphashc.........ps.scs.lh...........h.stptp.hhussFtEaL	......................................pIpphEppLsh.....phPps.Y+pFLcp.hsu.st..................h.s.u..p.lhs.....h......................................t.sh.hhpp.h...............htp.....ph..pph...............llh..p..s..s..s..s...s..h.hshc.........ptsps..lh.............................t.....p.....h.....h....hsssht-al.......................................................................................................	0	24	55	61
+14420	PF14569	zf-UDP		Zinc-binding RING-finger	Coggill P	pcc	Jackhmmer:A9T9M4	Domain	This RING/U-box type zinc-binding domain is frequently found in the catalytic subunit (irx3) of cellulose synthase. The enzymic class is EC:2.4.1.12, whereby the synthase removes the glucose from UDP-glucose and adds it to the growing cellulose, thereby releasing UDP. The domain-structure is treble-clef like (PDB:1weo).	27.00	27.00	42.80	42.10	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-9.87	0.72	-4.23	6	380	2012-10-03 15:03:13	2012-01-05 15:54:05	1	6	85	1	128	405	0	75.90	53	8.56	NEW	PKPLpNlNuQlCQICGDDVGVTl-GElFVACsECuFPVCRPCYEYERKDGsQuCPQCKTRYRRHKGSPRVcGD--EDDsD	...............suplCpICGDpVGls.ss.G-.sFVACsECuFPVCRPCYEYER+EGsQsCPQC+..TRYK.RhK.........Gs...Ptl.GD-.-.-.-.t....................	0	18	88	109
+14421	PF14570	zf-RING_4		RING/Ubox like zinc-binding domain	Coggill P	pcc	Jackhmmer:A5BM39	Domain	\N	27.00	27.00	27.00	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	48	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.35	0.72	-4.38	58	462	2012-10-03 15:03:13	2012-01-06 18:22:44	1	17	256	2	313	530	12	47.80	51	5.58	NEW	CPlCspch..DhsDpshhPC.pCuapIChaCapclhp.....s..t.....sGpCPuCRcsYc	.............CPLChE.h...DlsDt.sFhPC.sCGYQ...ICpFCapcIcp......s..t.........sGhCPuCR+sYp...........	0	101	187	261
+14422	PF14571	Di19_C		Stress-induced protein Di19, C-terminal	Coggill P	pcc	Di19_old	Family	C-terminal domain of Di19, a protein that increases the sensitivity of plants to environmental stress, such as salinity, drought, osmotic stress and cold. the protein is also induced by an increased supply of stress-related hormones such as abscisic acid ABA and ethylene [1]. There is a zinc-finger at the N-terminus, zf-Di19, Pfam:PF05605.	26.00	26.00	26.40	31.30	25.40	25.50	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-10.53	0.72	-3.72	49	170	2012-01-09 11:51:23	2012-01-09 11:51:23	1	4	26	0	88	170	0	98.50	30	47.24	NEW	slSlLp+...-L..R.-upLQuLL.GGu......sss.s..s...uo.ssusDPLLSSFlhsh.ss.scs.p...c..ssc..s...sssst....pc.s.Stpcphs..pp..sh..p.t.s..pss.LStc-pE....EpspRucFVQsLLlSTl	.......................hShLt+-Lc..-upLQsLLGGu.......tsts...s...ss...s.sssDPLLSSFlhshss.scs.p...pssp..s...sssst....ss.sshtpphs..pp.sh.p.....pss..Lopc-p-....c+spRupFVQtLlhSTl..........................	0	14	55	73
+14423	PF14572	Pribosyl_synth		Phosphoribosyl synthetase-associated domain	Coggill P	pcc	pdb_2c4k; Jackhmmer:Q14558	Domain	This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.	27.00	27.00	27.20	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-11.17	0.71	-4.54	11	6166	2012-10-10 14:25:38	2012-01-09 15:06:51	1	16	4467	28	1767	4367	2278	127.90	40	39.16	NEW	DYRNAVIVAKsPuuA++ATSYAERLRLGlAVIHGEsK-u.EsDh.sDGRpSPPsh.cs.............sslsssht..lPhhhsKEKPPlTVVGDVGGRIAIIVDDlIDDlpSFVAAAElLK-RGAYKIYVhATHGLLSuDAPcLlE-SsIDEVVVTNTlPH-lQKhpCpKIKTVDISllluEAIRRIHNGESMuYLFR	...............................................................................................................ptsssp..............................................................................................................................................................................................s.......M....p....l.I.G.D..V..c.G+..ss..lll...........DDhIDT...uGTlsp.AAc..s......L.c.-.p.G.Ap.c.VaAhs.TH.....ulh.S...G......s.......A...h.....-....p....l....p....s....S....s....l....c....E..lVVT.........D..T..I...s........l....s..c...t.........p..p....h....s....+.l.........c.hl.o...lu...s..l..lAEAIc.Rla.pp..cSlSsLF.p........................................................	0	573	1057	1460
+14424	PF14573	PP-binding_2		Acyl-carrier	Coggill P	pcc	CATH:3ce7A00	Domain	\N	32.00	32.00	32.00	32.00	31.90	31.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.40	0.72	-3.95	5	15	2012-10-02 01:16:24	2012-01-09 15:11:50	1	2	10	1	12	80	1	91.30	44	35.82	NEW	SPVVDTDINAVTNYIVGMCQKFLQKGEKVTPSSKLEELRTREDRLWDCLDTVEFVLDVEEIFDVTVPDEVADNFQTLQEIADFVVSERAKAGKFMK	................................................lpphllGhhpKaLpcspclTssoKLE...EhRT.+-sRhWDsLDTVEFVlDVEEhFDVTIPDEsADNhcTlQEIADaVVupRt................	0	7	8	11
+14425	PF14574	DUF4445		Domain of unknown function (DUF4445)	Bateman A	agb	Jackhmmer:C9L8Q5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 525 and 664 amino acids in length. The family is found in association with Pfam:PF00111.	27.00	27.00	29.30	40.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	412	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.02	0.70	-6.24	215	536	2012-01-09 17:49:09	2012-01-09 17:49:09	1	11	362	2	223	535	496	400.20	34	68.91	NEW	haGlAlDlGTTTlsutLlDLp...o.GchlussuthNsQhpaGsDVlSRIsaAt..p............sGhppLpptll.pslNpllsplhpp.......ss............................lshpcIhplslsGNosMpHLhLGlssptl........utsP........ahPsh..........sps..h.lpAp-l..Gl......phssputlalhPsluuaVGuDllAull.uss..ht.....p....p..cc..hs...LhlDlGTNGEllL...G.sp.cpllusSsAAGPAFEGusIspGM+AssGAI-cVpl....csss.............ph.psIG......................s........................ttP....................pGICGSGll-hlAplhcsGllcpsG+hsps...tt.............t.h.h.t.t..ttttalls...tt.......t.......t.h.......scslhloQpDI.cplthAKuAlhAGlphLlcc.sGlshs-l-clhlAGuFGsalshcsAhslGllPc.h.hp+lphlGNuuhtGAphsLls............................pptpcchpplscph..p..alEL...usp...ssF.pctFlpuhhh	............................h.aGlAlDlGTTTlsstLlDLp.........s.GcllspsuthNsQhpaGsDVlSRIsauh..p............sGhppL....ppslh.pslNpllpplhtpss............................lstppIhphslsGNosMtHLhLG.lssppLutuP........ahss..h..............pps..htlpAp-l...ul.............plps.tutlalhPsluuaVGuDhsAull.ust..h.t..................p....p..cc...hs..LhlDlGTNGEllL......u.sp....spllusSsuAGPAFEGusIssGhRAssGAI-cVplssps.................phpsIG...............s........................tts..............................................tGICGSGll-hlAphhcsGllcpsGchtps....t...............h...h...ttttphhls.t........t..th.spslhloQpDI.+plQhAKuAlhAGhphLlcp.hGlphpcl-clhlAGuFGsalshcsAhslGllPc.h.hp+lphlGNuuhsGAphsLL.s............................pp..ttpch..pclsppl..p..hlEL...usp...ssF.pctFlpuh.................	0	111	190	207
+14426	PF14575	EphA2_TM		Ephrin type-A receptor 2 transmembrane domain	Coggill P	pcc	CATH:2k9yA00	Domain	Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor.  This domain oligomerises and is important for the active signalling process.	27.00	27.00	27.00	27.00	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.24	0.72	-9.87	0.72	-3.58	64	1068	2012-01-09 18:22:38	2012-01-09 18:22:38	1	47	82	50	462	762	0	77.70	37	8.58	NEW	hllsu.ss.su..llhLllllh.l....h.l.hht..RRpp.hp..........+s...pp.p..s-c..h......th.pssp.....h..h...su.....l....................Ks...............YlDPaTYEDPspAV+EFA+EIDs	......................................................h.lhssss.su..lhhlls.l.l.s.h.....hl....lht....R+.....pp...hp...................................+s..pp..p.....s-c.....................ph.tpsp.........h..h.PG..h.........................................................K.s...........................Y.....lD....P....aT.YEDPNpAV+EFAKEIDs............	0	46	86	226
+14427	PF14576	SEO_N		Sieve element occlusion N-terminus	Eberhardt R	re3	Ruping B	Family	Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation [1]. This domain represents the N-terminus of SEO proteins.	27.00	27.00	63.20	32.00	22.90	22.40	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.82	0.70	-5.13	34	105	2012-01-10 14:54:50	2012-01-10 14:54:50	1	6	13	0	58	98	0	247.50	32	38.72	NEW	t.sDsplhcplhtTHssDs.cchDVcsLhsllpsIlp+us.hs............h..tt......t..p..cp...s.hshhcs.hhslc+ISCch.sKssutp.sAH.............pTThsILphLssYoWDAKsllsLAAFALpYG-FWhLsph.hsos.LAKSlAhLKpl.s..hp.ts...+sR.ss...lssLlcshlpVhcsIhEaccLssp.Y.....spDVPuLstAhpcIPlsVYWsItolVACsupIssl.........hspp..csaELS.shspKLssIhs+L+ppLshCcppI--...hEsYppLhclFpps+p	................................................sDs.hhcplhhTHs.ss..pchDscsLhpllpsllppss..h.....................t..p......hs.hc.s..htlcpIusphhsps..utt.puH.............tTThsll..sh.LssYoWDAKsVlsLAAFAlpYGcFWhLsph..s..ss.LAKSlAhLcpl.P..hp......+s+hps...lssLl+shhpVscsIhEaccLsst..Y......spDlPsLssAhpcIPlsVYWsItolVACsspIssl................h.t......................p..pt..........a-LS.shspKls.IhpcL+ppLphChppItc...h-tat.hhphhpp.p....................................	0	3	46	55
+14428	PF14577	SEO_C		Sieve element occlusion C-terminus	Eberhardt R	re3	Ruping B	Family	Sieve element occlusion (SEO) proteins, or forisomes, are phloem proteins which accumulate during sieve element differentiation [1]. This domain represents the C-terminus of SEO proteins.	26.00	26.00	31.60	35.60	25.20	22.60	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.61	0.70	-4.99	35	115	2012-01-10 14:55:34	2012-01-10 14:55:34	1	6	13	0	69	112	0	213.00	34	34.22	NEW	pscEEsLhpc.sWhh-llsc.lDPhlhpWlp-s..+YIhlYGGsDh-WIpcFTpsscslu.......psAclslEhhaVGKt............................pD.shlhaFWsclEShh.hoKh.ph.............cpscsDslhQE.lpplLSacts-pGWAlLSKG...ss....lhlpG+Gsshlpols-a-t.WKcpV.p.cGFshAFc-Yacplp...s..sccCs+l.l.Psss..GcIP-plsCP-..CuRsME.palsY+CCHc	........................s..ccctLhpc.pWhhpllhc..........lcstl.phlc-s.+aIhlYGGsDhcWIpcFTpssctlt.......psAcl.lEhhaVGKtp..........................h...pD.shlhhFWh+lEShhhSKh..ph.h...........ppspsDshhpE.lppLLsac.t.sptGWAll.o+G...ss....lhlpG+Gsshhpols-ast.WK-pl.p.cGFshAhp-ahpphp.....s...sc.Cs+h.h.ss.ts...Gplscp.lhCs-..CtRsME.pal.YpCCp................	0	3	56	66
+14429	PF14578	GTP_EFTU_D4		Elongation factor Tu domain 4	Coggill P	pcc	CATH:1xe1A00	Domain	Elongation factor Tu consists of several structural domains, and this is usually the fourth.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.66	0.72	-4.34	11	354	2012-10-05 12:31:09	2012-01-10 16:40:20	1	15	284	4	219	555	91	86.20	37	11.07	NEW	hpssGKhpV.psaslht+-.slVG.cVlpGlIhPGYKl...KG+c.VGhIhpIp+p+KpV-FAlsGD+VAl.lEG.hh...psc-GDlLEV	.........hh...Ps+l+IL..PpalFppp....DPlVlG.VcV.sGhlK.G.sPls.....pccG..h.c...l...G.h..lp.oIcp.sc.K.sV-.A+cGpcVulpIcs.......................................	0	72	122	170
+14430	PF14579	HHH_6		Helix-hairpin-helix motif	Bateman A	agb	Jackhmmer:C9L7X9	Domain	The HHH domain is a short DNA-binding domain [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.89	0.72	-3.94	364	7029	2012-10-03 02:11:09	2012-01-11 15:39:14	1	48	4452	9	1533	5939	2559	91.90	30	7.87	NEW	GlpllsPDlNpSp.h.c.asl............................................pst.........s......IRhGLsslKGlGpssscpIlp.tRp...tus...Fp.sltDh..hpRs..............tls+cslEsLhpAGAh.D.sh.....u..h...p..Rt..tL	...................................................GlplhsPDlNp.St.h.c.Fpl...............................................................................................................pst.........ts.........IhhGls...Al+GlGps.sscpIlc..sRp.....p.....G................Fp.sl.Dh..tpRs..........................ttls.+.+s.l.EsLhpuGAh.D.sl....s......p.Rt..........................	0	538	1027	1307
+14431	PF14580	LRR_9		Leucine-rich repeat	Coggill P	pcc	CATH:1a9nC00	Repeat	\N	30.50	30.50	30.50	30.50	30.40	30.40	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.49	0.71	-10.95	0.71	-4.71	6	1482	2012-10-02 21:32:02	2012-01-11 16:43:36	1	116	303	11	910	1732	20	148.50	27	32.21	NEW	MVKLTAELIEQAAQYTNAVRDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFPLLRRLKTLLVNNNRICRIGEGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLSILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEAEKMFKGKRGAQLAKDIA	.....................................................h....................................................................h.p.t.lt......h......p....h...c....h...L...s...ls..pN.t.l..p....p...l....p..........s...l...s.....................p............L........p...p........Lcp.L.......Ls..sNpI....s..p..l...........p..s..l.t.....t.....t..l..s...s..Lp.........p...Ls..L..s.sN..p.I...p..s..l.s.............s......l..p.......L..p..p.l...p..p.LppL..s...L......h.....s.....N...P..........l............s............p...........h............p.........p.Y....R.....hllhh.lP.p...Lc.hLD.hppl..ptp........E.+.t.A...............................t.tt..............................................	0	313	425	643
+14432	PF14581	SseB_C		SseB protein C-terminal domain	Bateman A	agb	SseB	Domain	This family consists of several SseB proteins which appear to be found exclusively in Enterobacteria. SseB is known to enhance serine-sensitivity in Escherichia coli [1] and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon [2].\	This presumed domain is found at the C-terminus of SseB proteins.	19.90	19.90	20.00	20.30	19.60	19.30	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.07	0.72	-4.20	72	744	2012-01-11 16:51:14	2012-01-11 16:51:14	1	7	695	0	82	441	11	108.70	51	42.24	NEW	p..shp....sGsplpls...cP..pc...Psphhsulsp.hhppptsVppAalthhpp.......tsppsshhlsl-hss....chppl.hpshup.hssshhss.hslchshls.s..tsluchhhpcspPFYpR	................EGGESLlLS...EV....AE......PPuQMIDSLTT.LFK.TlKPVKRAFlCuIKE......pp-AQPNLLIGIEADG.....DIEEI.IpAsGs.VATDTLPGDEPIDICQV+.c.GE....cGISHFlT-HlsPFYER............................	0	15	39	61
+14433	PF14582	Metallophos_3		Metallophosphoesterase, calcineurin superfamily	Coggill P	pcc	C0ATH:1uf3A0	Domain	Members of this family are part of the Calcineurin-like phosphoesterase superfamily.	28.20	28.20	28.20	28.20	27.80	28.00	hmmbuild  -o /dev/null HMM SEED	255	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.62	0.70	-5.23	6	31	2012-10-02 19:15:56	2012-01-11 17:04:52	1	2	31	9	11	163	10	169.80	37	57.98	NEW	M....thhscKlLAlSsh+Gch-hl-+LlclltEp.ssDAllllG-lhpspA+ucEYt............................pFFRtLuphslPsahlPGspDAPlchaLRtAaNhElVhPpl+sVHcoFAhhtG.allAGhGGElT-cucs-...thtL+YPuWEAEYpLKhL+-L+DhpKlhLFaTsP.......hcKGhccuGSpsVAcLlKTasPclVls.....uGsstcH..E.LGsoLVVsPGuLuEG-YAllDlcp+cl-hGsl	......................................................................................................................................................................................................................................................................................................................................................................................................h.L....p.....-.............h.......c..c.........ph.......I.....hl.F.Ht..PP.s.............htp..sh..u..csGS+sVtcLIpp..a.pPlls.Ls.....GHltcsp.t.h-plGs.Tl..lVNPGu.L.tp.G..-..aS..l..lshp...t............................	0	5	9	11
+14434	PF14583	Pectate_lyase22		Oligogalacturonate lyase	Coggill P	pcc	CATH:3c5mA00	Domain	This is a family of oligogalacturonate lyases, referred to more generally as pectate lyase family 22.  These proteins fold into 7-bladed beta-propellers.	30.00	30.00	30.00	30.40	29.90	29.20	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.16	0.70	-6.01	4	173	2012-10-05 17:30:43	2012-01-11 17:11:27	1	3	156	4	47	139	10	353.20	48	90.58	NEW	MAKGKhlsLsFcTa.DSsTsscVsRLTPsDVlCHRNYFYQKCFTpDGpKLLFuGsFDGshNYYLLDLsTQpAsQLTEGpGDNTFGGFLSP-DcuLFYVKNt+NLMRVDLsTLEEssIYpVP--WVGYGTWVANSDCTKlVGIEIpKcDWpPLTDWKKFtEFYaTNPpCRLI+lDLcTGEupVILQENpWLGHPIYRPhDDsTVAFCHEGPHDLVDARMWhINEDGoNhRKVKpHA.GESCTHEFWlPDGSALAYVSYhKGpopRaIhpssPsTLENcplhpMPsCSHLMSNaDGoLMVGDGssAPVDVpDsuGYKIENDPFLYVhNhKstpha+lA+HsoSWcVh-GDRQVTHPHPSFTPDDKtVLFTSDs-GcPALYhAclP-pl	......................................................................MAKG..l.Lpacsh.DspTGspVsRLTPs-lhCHR.NYFYQKCF....spD..Gs+LLF.uut...F..D..G.hNY.YLLDLtoppAsQLTE......Gt.....G...DNT..F.G......GFLS.s....-.D..culaY.VK..........st...+......sL.hcV-LsT..L.........c.....Ep.slYpVs..........-cWVGY.GTWVANS...D...CT+.lVG.I...E..I....t...+p.....................DW...pPL....s....DWp.hFp-...FaappPpCRLh+lDL....c.....T..GE...s...pVIhp.-spWLG.HPIYRPaDDsTlAFCHEGPHDLVDARM..WhlN.cDGoNh..RKV..+....pH.s.t.G...ESCTHEFWlPDG....SAlsY.V.......SY.h..K.G...ppsRh...IhphsP.............p..T......h...cs..c..t..l..hpM...P.s...CS...HLMSNaDGoLhVGD..G...u..ssPVDV....p......D.ss.u...YpI...-.N...DP.aLY.l.h.sh.p.s.........tp....t...+..lu+.....Hs..o......SWpV...hcGcRQV.T........H.....PHPSFTPDs+tVLFoSDh..cGp.PAlYhsplPt............................................................	0	7	25	36
+14435	PF14584	DUF4446		Protein of unknown function (DUF4446)	Bateman A	agb	Jackhmmer:C9L935	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 165 and 176 amino acids in length.	24.00	24.00	24.40	24.30	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.70	0.71	-4.38	123	292	2012-01-11 17:19:42	2012-01-11 17:19:42	1	2	289	0	74	243	26	149.80	32	86.90	NEW	.shl.....llulh.llslll.hl...hhlhhhh+...hp+lp++Ycthh....cGpsup.sL....Echlhphhcclcclppptcph.ccphcplppphp....pshpKlGlV+YcAFp....-hGucLSFulAlLDspssGllloula.uR-sshsYsKslppGpSp.htLSpEEppALcpAh	.............................s.hlllslh....llhllh..hl..hllhhhh+hp+Lc++YcthM....cGpssp.sL......Echl.hphhcclcclppptc.ph.ccphpplcpphp....pshpKlGlVRYsAFc....-hGucLSFulAlLDspssGllloula.uR.-p.ohsYuKsIppGpSp.hsLSpEEppuLcpAh..............	0	44	65	69
+14436	PF14585	CagY_I		CagY type 1 repeat	Bateman A	agb	Bateman A	Repeat	This repeat is found at the N-terminus of the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells ([1]).	25.80	25.80	100.40	25.80	17.60	25.30	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.27	0.72	-4.04	7	210	2012-01-12 14:30:43	2012-01-12 14:30:43	1	33	32	0	3	213	0	62.60	78	9.99	NEW	ETSKKsQQcSPQDLSNEEATEANHFED..KESKESSDpHLDNsTET.KTphD-s...KopETpsphspp	.........ETSKKTQQHSPQDLSNEEATEANHFEDSSKESKESSDHHLDNPTE.....T.....KTNFDE.KSEEhpsp.ss.............	0	3	3	3
+14437	PF14586	MHC_I_2		Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2	Coggill P	pcc	CATH:1jfmA00	Domain	Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.	27.00	27.00	27.40	27.20	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.17	0.71	-4.69	3	89	2012-10-03 22:02:01	2012-01-17 15:53:59	1	3	17	5	26	189	0	164.60	45	74.91	NEW	DAHSLRCNLTIKAPTPAD..WhEVKChVDEILILHLSNINKTMTSGDPGETANATEVGECLTQPLNDLCQKLRDKVSNTKVDTHKTNGYPHLQVTMIYPQSQGQTPSATWEFNISDSYFFTFYTENMSWRSANDESGVIMNKWKDDGDLVQQLKYFIPpCRQKIDEFLKQSKEK	........................................sHSLshNFT.I.Ko.ho+PGp.WCEuQs.hsc.phFLpa.s.ss.N.hsh.P.L.G..l.GKK.VNATpsWs-LTQsLs-lGc-LRhhLh-lKsp.h...K.TS.Gs.s......T....L.QVpMlsQ+cstphsuASWpFs.IssphshlF...D.s...hNMoWplIN.-AscIhEpWKcD+sLtc.ah.+.h...h.s.DCsphLcEFLt.....t.........................................	0	1	1	7
+14438	PF14587	Glyco_hydr_30_2		O-Glycosyl hydrolase family 30	Coggill P	pcc	CATH:3clwA02	Domain	\N	27.00	27.00	27.10	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	384	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.38	0.70	-5.53	4	205	2012-10-03 05:44:19	2012-01-18 13:33:11	1	21	143	6	97	244	11	287.10	27	49.98	NEW	cppLslshposaQpIDsFGASDAWRsQalGKNWP.EK+ppIADLLFSpEhDppGNPKGIGLShWRFNIGuGShEpGcsuGlsspWRRsECFLot-GsYDWsKQuGQpWFh+AARERGVpphLsFS.SAPhaMT+NGpuhoo-cs.phNlppsKhcsaAcFLs-sspph.pc.GhslNYlSPlNEPQW-W.usuuQEGo.sTN--hpchVphLD+cLpcRplsTp.IslsEsGsIpYLacs.sNtpsRDN.IcshFspsuphSlhpLssVtpsVouHSYWSsaPhspLVspR+pLspclup...ush+aWtoEYC.hEp..Ns-.spGsGs.RDLGMpsALYVARlIHpDLTlANASuWQWWTAlSthsYKDGLIalDcsp.tsG.Sh.........KpDG	...............................................................................................................ht.....lp.tt.hQ.phcsaGsS.sW...hp..h.h....G...hst....t....pp....p.pls-hLFo..p.p........................p...G...l...GLolhRaNlGuG............us.t..p.....t........p............s...........s..t....l..t.........s...............h...h......p....s...p.........s.a.......h.......s...sc.........s...s.........a.........s......W...s..t...s..t..u.QRh..h.l.p.t.A.+.p..+..G.ls..p....hh...uFu.NSP...PhahTpNGt.....s...s.s.....s......s....t....s.....s.....s.............NL..cs....-p.apsFApYLusVsc....th..pp..........t.......G.l.phshlsPhNEP.s...h..s...........W.....s..........s.....s........p..........QEGs..ths.s.p.p..sphlp.h.Lspp.lpppsl..s.sp..l.h.h..s-...................................................................................................................................................................................................................................................shttst.....................................................................................................	0	34	71	91
+14439	PF14588	YjgF_endoribonc		YjgF/chorismate_mutase-like, putative endoribonuclease	Coggill P	pcc	CATH:2otmA00 	Domain	YjgF_Endoribonuc is a putative endoribonuclease. The structure is of beta-alpha-beta-alpha-beta(2) domains common both to bacterial chorismate mutase and to members of the YjgF family. These proteins form trimers with a three-fold symmetry with three closely-packed beta-sheets. The YjgF family is a large, widely distributed family of proteins of unknown biochemical function that are highly conserved among eubacteria, archaea and eukaryotes [1].	35.00	35.00	37.20	36.70	34.20	34.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.80	0.71	-4.28	2	1260	2012-10-01 19:40:00	2012-01-18 13:58:18	1	6	1017	15	475	1093	1483	146.50	44	92.19	NEW	EoRLhAhGL.LPcssAAlGsYEPauhhus.lhTShQhPa.ttpLha.G.LGsshosp-GhAAsRLssLNulAQLtpAsGpLupl.plhRL-GhlsspQsh.-hPhsLDuAScLL.-lhGEtGRHuRhhhsp.VMPLsu.shlhhFAEl	....................................................t+LtpLGlpL.P..t.s.....ss.P..s.A.sYVPsl...p.o....G....s.h.l.a.sSGQlP...h....h..s..G...p.....l..h.hsG..K.....l...G.......s.........-.............l....o..s...Ep..upp..A...ARh...sAlNhLAs.lc...u...........t.........l....G......s.......L..-+.lpRlV..KlsGFVsS..sssF.....s.pQ...s......tVhNGAS-LlscVFG.-.s..GcHARSAVGVusLPhsusVEl.Eh...................	0	150	300	384
+14440	PF14589	NrfD_2		Polysulfide reductase	Coggill P	pcc	CATH:2vpzC00, Pfam-B_200168	Domain	Bacterial polysulfide reductase is an integral membrane protein complex responsible for quinone-coupled reduction of polysulfide, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfides are a class of compounds composed of chains of sulfur atoms, which in their simplest form are present as an anion with general formula Sn(2-). In nature, polysulfides are found in particularly high concentrations in extreme volcanic or geothermically active environments. Here, the reduction and oxidation of polysulfides are vital processes for many bacteria and are essential steps in the global sulfur cycle. In particular, the reduction of polysulfide to hydrogen sulfide in these environments is usually linked to energy-generating respiratory processes, supporting growth of many microorganisms, particularly hyperthermophiles.	27.00	27.00	28.90	28.60	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.74	0.70	-4.72	3	4	2012-10-01 19:35:38	2012-01-18 15:02:00	1	1	4	8	2	10	1	254.00	66	99.22	NEW	TEFYGLPNApEFWHWTNLLHFlLVGLAGGsAFLTALLHLKGcAEARRYTLaALuLIALDLFlLWAESPARFRFTHVWLFLSFHPTSPIWWGAWGLALSFLouGLLYLGKGPuRsLAWuLLlFSLVALAYPGhALAVNLNRPLWNuLLAGLFPLTALVLALGVAVLLKSuWALaP.LRVLAGASLhLAhLYPlTLs...sEAR..GHLWEEGGhhYGLFLLLG....LGAFhpERLAPWAGhLAAAG...LRALLVtsGQWQGL..G	......TEFYGLPNAtE.FWHWTNhLHFlLVGLAGGsAhLsALLHL+G..psE..ARRYTLh..A..LuLIALDLFlLWAESPARFRFTHVWLFLSFHPsSPIWWGAWGLA.LuFLouGLLYL..G.KG...P......pRhLAW......uLLlFSLVALuYPGhALAVNLNRPLW...Nu..L.hA.GLFPLTALVLALGlAsLL+SsWA...LaP.LRl.LA....GASLhLAhL.YPhTLs...sEAR..tHLhEE..GGhhYGLFLLL.G....LGsFhpERhAPWAGhLAAAG...LRALLVhsGQWQGLG.........................................................................................................	0	0	1	2
+14441	PF14590	DUF4447		Domain of unknown function (DUF4447)	Eberhardt R	re3	Jackhmmer:Q8EAP9	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 170 amino acids in length.	27.00	27.00	314.00	313.80	24.80	24.40	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.13	0.71	-4.66	5	28	2012-01-18 16:17:44	2012-01-18 16:17:44	1	1	28	4	13	19	1	166.00	82	99.49	NEW	MSKNlGLNAIEMQYLRpSLGLTsAQVAplTKsSE-DVlAWEAGEppAPtLAQKKLLEIDEIIEMQVLNToDGIEELFKKEPKRRLAFVVYPTQAlYTQYNPEFLSSLPLTELYNTAAWRIKKECKLVLEVDVoLVPLDVEuYKAYREcNGLuESRESRAKWAATQL	MSKNIGLNAIEMSYLRQSLSLSsAQVGpLTsHSEADVLAWEuGEpsAPELAQKKLL-IDDIIEMQVLNTCDGIEELFKKEPKR+LAFVVYPTQAlYTQYNPEFLSSLPLTELYNTAAWRIKKECKLVLEVDVSLVsLDVEAYKAaREpsGhSESRESRAKWAATQL	0	1	2	8
+14442	PF14591	AF0941-like	NTP_transf_5;	AF0941-like	Coggill P	pcc	CATH:1yozA00 	Domain	Members of this family are of unknown function.	22.60	22.60	22.60	23.50	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.74	0.71	-4.08	6	11	2012-01-18 17:29:05	2012-01-18 17:29:05	1	1	11	2	9	11	0	107.20	28	84.46	NEW	hpsTal-KltELh+.....t.hl.-stcclEclscpLh........scEsItEh..F+pDhE.IlchapsGchocEEAhppLp.Lc.hA.spLppah.clt-lLcchEtchpchltch.c.........ls..l.Y.hcp....lcpstcE	....ohl-KLtELlp.....pplIsDlp-cL-EIhcpls........scEpIcEh..F+sDhc-llc-hpuG-I--EEApcllc.l.......................................................................................	0	1	6	9
+14443	PF14592	Chondroitinas_B		Chondroitinase B	Eberhardt R	re3	Jackhmmer:Q46079	Family	This family includes chondroitinases. These enzymes cleave the glycosaminoglycan dermatan sulfate [1].	24.00	24.00	24.20	24.00	23.90	23.70	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.67	0.70	-12.61	0.70	-5.66	6	114	2012-10-02 14:50:22	2012-01-19 10:54:16	1	13	78	4	66	132	31	320.70	28	50.89	NEW	VSo.sELtcAlspsKsGspIlLKsGlaKDVQIKFpGcGTK-pPIsL+AETsGKVFIEGsSpLEluGcYLlVcGLaFKNGaoPspsVIuF+su.cs....luNas+VTNCVIp-FspssR-psspWVp..thhG+HNclspChlsGKsNhGPTlRls......lcGsp.ultNYHpIVpNHFGPRPpKGGspGETIQlGsSaoSMoPu+ThlsNNLF-cCNGEVEIISSKoNFNla+NNlFacSEGSlVhRHGNYsslDGNaFIGssssEsYGGIRlINTGHWlsNNYFYtlKGppFRSslAlMNGIPKSPLNRYNQVTDVVVAYNTalDss.SPaQFGVGpNlsppDVLPcSEIRSARPhRhplsNNllaNcc.scphPllcp...Dcs...sFKsNhlssp.ss.......Lhsp.ctshTclutNhps.ps.....sshK.DlEsh.pGFDF-	......................................tplppAl..p.sspsGDpIlLtsGsa....s...s...h.p...lhh.p.s.pGTpspPIslpAps..sG.pVhl.s....G.....pu.......p.....lpls...........G..p............alhlpGLhF.p.suh.....ss.t..tth.hthp.s..........husps+lT..pssh....t..a....s.................tp.....t.......t...........al..............hhGppspl-ps.h.s...K..pshGsh.lhl...................tstt...s.tp..hc..p.I....cpNaF...t........p..........h........u....u........N.uu....Eslpl.Gh..S..t.u..h.s...u.shlppNhFcpss..GE.sEllS.KSstNhhptNshhpspGslshRHGp.shlpsNhalGst.......................hGGlRlhspsphlhsNYh.sh..........p..G........h........t........h..h..ushs..........hps....................s.t....s.........s.ta...s.p.s.l..Nshlsst....h.hs...................................................................................................................................h...........................................................................................................................................................................	0	19	53	64
+14444	PF14593	PH_3		PH domain	Eberhardt R	re3	Jackhmmer:O15530	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.21	0.72	-4.14	31	202	2012-10-04 00:02:25	2012-01-19 14:29:39	1	8	127	7	132	503	8	102.20	47	18.57	NEW	shWcpFlp...sclIlKpGhlpKR..+GLF..uR+RhLLLT-u.....P+LhYlDPspMhhK.GEIPWo...ppLpsEsKNhKpFalHTP.....sRsYYLpD.......scupAhcWscsIpclppphhp	........................................WcpFl-....splILKhG.VcKR.....KGLF.......uR+RpLLLT...-G................P.....+L.......hY.V.DP.s...s......h..l.l..K......G..E..I.PWS.........p.-.L..+....s...........E......s.......KN.....F.......K......p........FaVHTP...........sRTY.a.L...D............sp.u.p..A.hc...Ws+tIp-lhc....p........................................	0	58	76	109
+14445	PF14594	Sipho_Gp37		Siphovirus ReqiPepy6 Gp37-like protein	Bateman A	agb	Jackhmmer:C9LCM0	Family	This family includes numerous phage proteins from Siphoviruses. The function of this protein is uncertain, but it is related to Pfam:PF06605. In Rhodococcus phage ReqiPepy6 this protein is called Gp37 [1].	26.10	26.10	26.30	29.60	25.90	26.00	hmmbuild  -o /dev/null HMM SEED	335	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.90	0.70	-5.20	43	160	2012-01-19 16:55:40	2012-01-19 16:55:40	1	2	128	0	25	151	20	326.20	24	86.66	NEW	shphlG.......................l-sap..SLpasc+a.tssGsFE...lclshsppp.................hphL.ppsshlhh...pstp...p...........ssllp..phphsp-p...tpsplsVpGhs.hpshlscRlshss..........h.......hhsussEslhcphlspsshssspssRtIs...sLt..lussts...tupplshp.spa.csLh-tlppl......spssslGaclh.........hc.p..............p..pch.lF-lhpGpDh.......sssllF.....StcasNlpstpatpos.sapNssh.VuGpGEGp.sRthsp............l....us.....s..p...GhcRcEhalDA+-ls.................................phhspLpp+GppcLs.Ettthtshcsplpssst......hhYtpDasL.GDhVolpscth..GlphsspIoEl.........p-ha-..psGh.plpssFGs	....................................p.hu..l-.apSlphpcpa.tssusFE...lhhshptt..................hchl.ptsshlhht..ss..............sullp..thplpps-...ttphlslpGhs.hpuhlscRIlhs...........h.......phoGpsEslhcphlppphh.s...tRpls...tLh..lsssts...ps.tsl.p.hp..spa.pslh-tlppl......spssshGaclh.........hs.p....................................p...tth.hhchhpu.pDh.......ssslhF.....St-ac.Nlhstpapcst.shpsssl.luGcGEGp.sRphsp.............................l................ss.....h..s.........GlcRhEhalDA+-lp.................................thhspLpp+Gpc+Ls..Ettph.hshpsplp.ps.......hhYttDacL.GDhVshtsp.h....Ghphsshlspl.........ppphc..psGh..plpspaGp........................	0	10	23	25
+14446	PF14595	Thioredoxin_9		Thioredoxin	Eberhardt R	re3	Jackhmmer:Q9I4A4	Family	\N	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.63	0.71	-4.58	80	573	2012-10-03 14:45:55	2012-01-20 08:05:38	1	3	547	1	117	2556	1082	127.40	35	70.61	NEW	Ghshs-alp.........phsp..........spc.chpclhcphplsp-tpp...hhpthspsh.phLllsEsWCGDuhhslPllp+lu.chs..slcl+llhRDcsh-lh....-paLT..ssu+uIPhhlhhD..........ps.hp.l.shWGPRPptlpc.hh..........sph+	...............................................................shspalsthpt..........Nppph.h..plYps....ap...lsp....-..p....hhch..h..p.t....s..h..+.l.L.V..l..o...E...sWCGDAhhsl.....Pll....c....+I.u...E....s....t..........Nl...-...l...+l..h....t..R...D......-..s.p..c..L.h..............DQYLT....sspu.....R.....u......IPl.F.lFls...........cp...hcp..ss.W....GP....R.ssclpc.hl.pph.t.................................................	0	40	85	105
+14447	PF14596	STAT6_C		STAT6 C-terminal	Eberhardt R	re3	Jackhmmer:P42226	Family	This family represents the C-terminus of mammalian STAT6 (Signal transducer and activator of transcription 6), it contains an LXXLL motif which binds to NCOA1 (Nuclear receptor coactivator 1) [1].	25.00	25.00	26.20	25.30	24.00	21.90	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.35	0.71	-4.37	2	54	2012-01-20 10:05:42	2012-01-20 10:05:42	1	5	26	1	17	45	0	168.10	78	23.30	NEW	PLPTPE.phPTMVPSYDLGMAsDoSM..QLusDMs...YPPpSHSI.saQsLs.EESlsVLsAFQE.PHLQMPPshuQMSLPFDQPHPQGLL.CQsQEHAVSSP-PLLCsDVsMsEDSCLoQPVsuFPQuTWlG..........EDhFPPLLPPTEQDLTKLLLEGQGEuGGGSLGAQPLLQPS.YGQsGISMSHhDLRsNPSW	....PLPTPE.QMPTMVPSYDLGMAPDS..SMsMQLuPDMVs..QVYPP..HSHSIss.YQuLs.EESVsVLsAFQE.PH.....LQ...MPP.....sLuQhoLPFDQPHPQGLLPCQPQEHAVSSP-PLLCSDVTMsEDSCLoQPVsuFPQGTWlG..........EDhFPPLLPPTEQDLTKLLLEGQGEoGGGSLGsQPLLQPSpYGQSGIS.MSHhDLRsNPSW......................	0	1	1	2
+14448	PF14597	Lactamase_B_5		Metallo-beta-lactamase superfamily	Coggill P	pcc	CATH:2p97A00	Domain	This is a small family of putative metal-dependent hydrolases.	28.40	28.40	28.80	28.70	28.30	28.00	hmmbuild  -o /dev/null HMM SEED	199	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.30	0.71	-4.92	4	14	2012-10-02 15:46:01	2012-01-20 10:58:09	1	2	14	2	5	21	24	190.30	39	92.85	NEW	MKSLHRPDLYSWSsFNPARNIDFNGFAWIRPEGNILIDPVALSNHDWpHLESLGGVVWIVLTNSDHVRSAKEIADQTYAKIAGPVAEKEpFPIhCDRWLSDGDELVPGLKVlELpGSKTPGELALLLEETTLITGDLVRAa+AGuLplLPDEKLhN+pcsVASVRRLAuLEKVEAVLVGDGWSVFRDGRDRLcELVATL	.........................................................................RPDLasWShFs.t+NlDFNuhhhhRP-GNlLIDPlsLSscDhp+LpulGGlsaIVLT..NsDHlRuAcchAcphtA+lhuP.......su-.......c....cph.....PlssD+hLsDG-..pllsGlpVlpLp..GpKTPGElALL.L.--..s.sL.IoGD.Llhuh.uGsLshLPDcKhhshpcshtSl+RLAth..ch-slLsGDGWslh...pcupttLtpLh....................	0	0	2	5
+14449	PF14598	PAS_11		PAS domain	Eberhardt R	re3	Jackhmmer:P70365	Domain	This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6) [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.09	0.72	-4.11	22	2159	2012-10-04 01:10:46	2012-01-20 11:08:31	1	50	589	39	703	2822	16	106.50	29	13.98	NEW	p-pFoo+hshsGKIlplDpsslphsh.tahp.c-.lhspshaphhH.pDhp...hpp+h+phhp..........pGp.s..tSsh..YRlphpss..salhlpTpuplhp..sppssp.phlhssppllsEpps	.......................................h..pFhoRHsh..s..sphtalDp.+...s.............s..shl..GYhP..p-..L.l.G..p.s...hh.c..a.aHscDhp....lp..c.sac..p..lhp....................................pGp..s.....po..s.........Y..Rhhs+sG..salh.lc...............Tphpshh......Nsh.op..c.......c.a.llspppll.....t...............................................	0	147	210	422
+14450	PF14599	zinc_ribbon_6		Zinc-ribbon	Coggill P	pcc	CATH:2k2dA00	Domain	This is a typical zinc-ribbon finger, with each pair of zinc-ligands coming from more-or-less either side of two knuckles. It is found in eukaryotes.	27.00	27.00	28.00	28.00	26.30	26.20	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.45	0.72	-4.18	75	401	2012-01-23 11:24:43	2012-01-23 11:24:43	1	18	217	1	260	390	11	59.80	44	12.44	NEW	lsDMsphachLDpEItspP...MPppYpsphshIlCNDCss.pSpVpaHhlGhKCsp..C...sSYNTpp	.............h.hDMsthactLDtpluspP........MPp-Ypsp..pshILCNDCs..........s.cS.p.V.p....FHhLGh.KCtt..CtSYNTpp...............	0	67	148	216
+14451	PF14600	CBM_5_12_2		Cellulose-binding domain	Coggill P	pcc	CATH:1aiwA00	Domain	This C-terminal domain belongs to the CAZy family of carbohydrate-binding domains that are associated with glycosyl-hydrolases. It is suggested to bind cellulose.	27.00	27.00	27.30	28.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.12	0.72	-4.34	5	106	2012-10-03 03:17:01	2012-01-23 14:37:49	1	26	74	1	33	110	1	59.30	49	6.53	NEW	TssCANsNVYPNWVSKDWAGGQPTHNEAGQSIVYKGNLYTANWYToSVPGSDSSWTLVGSCN	.......................sss.lN...sYPsWsppDatu.ssoHAssGDpMla..puslYpANWWTsShPGSDuSWohlh...s....	0	2	22	27
+14452	PF14601	TFX_C		DNA_binding protein, TFX, C-term	Coggill P	pcc	CATH:1nr3A00	Domain	This is the C-terminal region of TFX-like DNA-binding proteins.	27.00	27.00	30.10	29.60	22.70	19.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.72	0.72	-9.49	0.72	-4.19	28	73	2012-01-23 14:39:50	2012-01-23 14:39:50	1	3	69	1	53	84	0	82.70	30	56.08	NEW	ARETLpFhpsLsAPlplslcpGTDla-lPchlaspuDcsGlKVpasoh-Lhphlp-sAs-tlcsRhl+cchhlhlspcG-lplp	..A+pTLthacplpAPlplplctGTDla-lPchlaccuDctGlKVpYsohplhphlp-pAsphlcsRhlccshhlhlspsGclpl.........................	0	9	29	42
+14453	PF14602	Hexapep_2		Hexapeptide repeat of succinyl-transferase	Coggill P	pcc	CATH:2rijA03	Repeat	\N	27.00	11.00	27.00	11.00	26.90	10.90	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-7.50	0.72	-4.39	86	8656	2012-10-02 11:29:45	2012-01-23 15:54:45	1	152	4074	116	1925	24566	14688	33.80	33	14.21	NEW	sltIGcsChlGAN.us..l..G..lslGDssllsAGlhlos	.......................................lhItcss.h..I....G......u......p..uh......l..............G..............l......p.....lG-......ss.ll.u......sGshls.......................................	0	584	1174	1585
+14454	PF14603	hSH3		Helically-extended SH3 domain	Coggill P	pcc	CATH:1ri9A00	Domain	This domain is the 70 C-terminal residues of ADAP - Adhesion and de-granulation promoting adapter protein. It shows homology to SH3 domains; however, conserved residues of the fold are absent.  It thus represents an altered SH3 domain fold. An N-terminal, amphipathic, helix makes extensive contacts to residues of the regular SH3 domain fold thereby creating a composite surface with unusual surface properties. The domain can no longer bind conventional proline-rich peptides [1]. There are key phosphorylation sites within the two hSH3 domains and it would appear that binding at these sites does not materially affect the folding of these regions although the equilibrium towards the unfolded state may be slightly altered [2]. The binding partners of the hSH3 domains are still unknown [2].	25.70	25.70	25.90	25.80	25.20	25.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.95	0.72	-3.97	3	112	2012-10-02 18:48:24	2012-01-24 09:38:00	1	4	35	1	63	125	0	81.50	52	13.02	NEW	FRKKFKYDGEIRVLYSTKVTTSITSKKWGTRDLQVKPGESLEVIQTTDDTKVLCRNEEGKYGYVLRSYLADNDGEIYDDIADGCIYDND	.....FRKKFKa..-GEIpVlhpshlsss.hso++hGs+DLsI+sGEtLEVIp..hT-..c..sclLCRNpcGKYGYV.RotLh..-...s-lYDDl....................................................	0	4	9	20
+14455	PF14604	SH3_9		Variant SH3 domain	Coggill P	pcc	Jackhmmer, JCSG:target_422527	Domain	\N	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.82	0.72	-8.26	0.72	-4.38	37	9839	2012-10-02 18:48:24	2012-01-24 16:52:14	1	624	319	119	5343	17510	50	51.00	31	8.53	NEW	Alasap.sps..p.s..E..LplptG-hlhl..h..pp.....t..p...ssW.hh.u..p....h..sG..ppGhhPssYlp	......................Alasap..u....ps........s...c.......E......Lsh.p.t...G.-..l.ltl...l...pp...................s...-.....cGW..ap.G....p..................h.....sG........pp..G..h.FPusYVp............	0	1250	1872	3407
+14456	PF14605	Nup35_RRM_2		Nup53/35/40-type RNA recognition motif	Coggill P	pcc	Jackhmmer, JCSG:target_422743	Domain	\N	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.33	0.72	-4.19	21	98	2012-10-02 20:46:34	2012-01-24 17:02:17	1	12	56	0	66	283	2	55.80	26	9.42	NEW	spWlsVoGat..hcpt....thVhc.....aFp.s.hGpIlc...pphs................tsshhYlpYtsphssptAL	..................phlsVsG..as..scpt.....phlLp.....HFp.s.hGcIsc........hpls.........................tppshhhlpatschsA-pAl.....................................	0	23	29	47
+14457	PF14606	Lipase_GDSL_3		GDSL-like Lipase/Acylhydrolase family	Coggill P	pcc	Jackhmmer, JCSG:target_416889	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-11.03	0.71	-4.54	20	244	2012-10-02 11:02:24	2012-01-24 17:22:51	1	7	172	2	67	573	133	161.20	31	41.20	NEW	cK.PlVhYGTSIsQGAsASRPGMuaTsILuR+hstsllNLGFSGNu+hEsEls-llu-l.DA.ulallDslPN..........h....ospplpcRhtshV+tLRstHPcTPIlllEchh.hsps.hhcpptpcchpppspslpcsacp.LppcGsKslYalsucsh.lGpDuEuolDGsHPoDLGhhRaActaptll+	.................................................................................p.hlhYGoSIo.QGus....A..o+....P......u.....h.sasslhu......R.....p.....h.......s............h.....c.......l.......l.......NLG.....FSG...s..u....h....L........-.......................h..A...c.h.....l..s....-.....h...c.....A...clhs.....l....-.hhsN...................h....ssc...thppphpsFlcplRptH..P....sT.Pll...llps.hh..h.tt.....h..pt........................t.t......t....tt.p..t..hhtphhtt....h...t......t....t..sl..h....h..l...t...t...t...p......h.....s.......s............t....h......h.....s.....D....h.h.H.sshGh.hhup.h............................................................................	0	27	58	67
+14458	PF14607	GxDLY		N-terminus of Esterase_SGNH_hydro-type	Coggill P	pcc	Jackhmmer, JCSG_target_416889	Domain	This domain lies upstream of SGNH hydrolase, but its function is not known. There is a highly conserved GxDLY sequence-motif.	27.00	27.00	51.80	44.00	25.90	24.50	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.84	0.71	-4.73	44	142	2012-01-24 17:32:33	2012-01-24 17:32:33	1	6	85	0	28	136	91	147.60	34	36.76	NEW	sphpahsstph...sltG+uh.ssp..shYpRLPsptpst...lptsVhsLuppSAGlslpFpTsSspIps+aplsss.hshspMsssussGlDLYsts..sGpWpasus.up.sht....s.stshlhpshss......pt+EahLYLPLYsslpsLEIGlspsuplp	...........t.phpahsspph....slhG+uhtsp...shYcRlPsshpsh....sptslhpLu+sSAGlAlpF+oNSspIpl+apltss..hphsHMsssuhpGlDLYshp..sGpWpasss.up.sst....s..spshlhpshps......pt+EahLYLPLYsslpoLcIGVsssApl.p.................	0	16	27	28
+14459	PF14608	zf-CCCH_2		Zinc finger C-x8-C-x5-C-x3-H type	Wood V, Coggill P	pcc	Pfam-B_880 (release 26.0)	Domain	This is a zinc-finger of the type C-x8-C-x5-C-x3-H.	27.00	8.00	27.00	8.00	26.90	7.90	hmmbuild  -o /dev/null HMM SEED	19	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-6.79	0.73	-6.70	0.73	-3.78	44	1117	2012-10-01 21:35:20	2012-01-26 16:52:10	1	44	235	0	664	1211	11	18.40	40	10.59	NEW	.C+.hhss.Cp.s.cChatHP	..........C+.ah..ss..Cpp.s..cChFtHP..	0	185	320	526
+14460	PF14609	GCP5-Mod21		gamma-Tubulin ring complex non-core subunit mod21 	Wood V, Coggill P	pcc	Pfam-B_276835 (release 26.0)	Family	GCP5-Mod21 is a non-core subunit of the larger gamma-tubulin ring complex that effects microtubule nucleation from both centrosomal and non-centrosomal sites. This subunit, unlike GCP2 and and GCP3 and others, is not thought to be essential for viability in the fission yeast, and may not be expressed in very high concentrations.  Fission yeast can form a large gamma-Tubulin complex C similar to that found in higher eukaryotes and this complex is important for maintaining normal levels of microtubule nucleation in vivo [1].	27.00	27.00	28.80	27.90	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	653	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.02	0.70	-13.14	0.70	-6.41	4	5	2012-10-02 13:20:28	2012-01-31 09:18:48	1	2	3	0	4	28	0	519.00	25	90.96	NEW	VhsplEuls-K.phpshps.ANshcs+h--.lDR..VpsustsS.LHhpILHhLLEhSssPocss..KpPs.KclNsslEpEA.hspDsp.hpp.spGD+WD..ls-WSp......VTcsEEoEp.ss-NEchs-susaPcIPs..+hcNapp.chhhlFccpuQplhD+h.EKc..........lhRIuEQshhtE.oIhhLhG..............plLchlP....h.csLph.Ippo.LhchpsaG+sh-lhN.QVAsp+pCphahsDss...........DpEKpEsFls.hhlhQphTPphpuhlK....cLL.L.TpVRKht..Ihp...LptsspH.pKF......FR.AalchuppVhDhLpohhFIahpRhpN...........SLhhuthhpphYtEuh.Is.lhhpllsls+.TssasIuo.hLsILhpp..s.hpthcSlL.-aS..FLhKcCh..........ASQt.sFhhlV.sas.phsNhpp-pEshIcpslshpss..lsshc.uLsL.a-l.............ppaosRF.sL.pt.-EsacpLspKhFuKhlhtc.salsT.+salhp.ppcFTc.-plu.F.GVats..p-lssppVhtE.EK.....hlLKp+pKpLhsFhhsRstsL.su-hsshHK-.LtslM-......NsYKTplup.ID.pRhV....Dsp.shhlupluDllhc.up.lhscshpa+SsLs-tIhpshs	....Vh-pIEulsDKhphpshps.ANshcs+h--.lDR..VpsustsS.LHhpILHhLLEhSssPo......css.........KpPs.KclNsslEpEA.hs.pD.s.p.hp..p..spGD+..WD...ls-W...Sp...........VTc..s..EEoEp..s...s-...NEchs-su.sa..P.c.IPs..+hcNa.pp.ch.h......hlFc..c..puQplhD+h..EKc..........lhR.....Iu.....EQshhtE.oIhhLhG..............pl..LchlP....h.csLph.Ippo.LhchpsaG+sh-lhN.QVAsp+p.....C.....phahsDss...........DpEKpEs.Fls.hhlhQphTPphpu..hlK....cLL.L.TpVRKht..Ihp...LptsspH.pKF......FR.AalchuppVhDhLpohhFIahpRhpN...........SLhhuthhpphYtEuh.Is.lhhpllsls+.TssasIuo.hLsILhpp..s.hpthcSlL.-aS..FLhKcCh..........ASQt.sFhhlV.sas.phsNhpp-pEshIcpslshpss..lsshc.uLsL.a-l.............ppaosRF.sL.pt.-EsacpLspKhFuKhlhtc.salsT.+salhp.ppcFTc.-plu.F.GVats..p-lssppVhtE.EK.....hlLKp+pKpLhsFhhsRstsL.su-hsshHK-.LtslM-......NsYKTplup.ID.pRhV....Dsp.shhlupluDllhc.up.lhscshpa+SsLs-tIhpshs........................................................................	0	2	2	4
+14461	PF14610	DUF4448	GPI-anchored_2;	Protein of unknown function (DUF4448)	Wood V, Coggill P	pcc	Pfam-B_5686 (release 26.0)	Family	This is a family of predicted membrane glycoproteins from fungi. However there appears, visually, to be some similarity with the family of GPI-anchored fungal proteins, Pfam:PF10342.	27.00	27.00	27.10	27.30	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.44	0.71	-4.81	53	151	2012-10-04 12:14:07	2012-02-01 17:11:59	1	2	119	0	114	146	0	188.40	21	49.05	NEW	ssstsusss...hhtCsspph..........ttPFCtPccssclhsspTYa.lTWsspaF............tp..VplplsYssssstpt..........................................................sha...sS-h..lsNspGaaslplcppWL........psp.h.........sslolp..thsstssh..s.h..........pGPpVtltsp.s....ph.s...t...pt..........................hlhlulPsslsh..hhlhhhhhhhh.p+cpRclu	............................t.ssh.tCpspph............tP.FCtPpcsspltsspTYa......lTW.spaF..........ssss..Vpltlsahppstspt........................................................tha...soch....lssst.GhhslplpppWl...........psp...........sslol.p.h.thss.ssh..ssh...........................pGsplhhssp.sh...thts...t..st...................................hlhlulPlslss..hhlhhhhhhhh.p+.cpRch................................	0	30	66	99
+14462	PF14611	SLS		Mitochondrial inner-membrane-bound regulator	Wood V, Coggill P	pcc	Pfam-B_1679 (release 26.00	Family	SLS is a fungal domain found bound to the mitochondrial inner-membrane [1]. It reacts physically with fungal Kar2p to promote translocation across the endoplasmic-reticulum membrane. This action appeared to be mediated via the promotion of the Sec63p-mediated activation of Kar2p's ATPase activity. This indicates that the Sls1p protein is a GrpE-like protein in the endoplasmic reticulum. In S.cerevisiae the SLS1 gene (ScSLS1) is not essential but is also involved in ERAD and folding [2,3].	33.70	33.70	33.80	34.20	33.60	33.50	hmmbuild  -o /dev/null HMM SEED	210	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.24	0.70	-11.20	0.70	-4.91	34	140	2012-02-02 14:41:00	2012-02-02 14:41:00	1	3	113	0	84	142	0	207.30	21	25.97	NEW	sKptLsc+Ilc-sWpLslpscl........Gplplplp......sp.hslLhhspphhlppl.....hpppss+Iclppphs.hlcIouscpssphlpptlpchhsclcppplsls.h..h..t.pt...........hpsthLphlpphtpshhchssssp.hhhhhht................tsppps-pscRhLhhAl.s.pspsppshhss.hs..tst.h.h.sh..........pslsWhsRp.cpWhRWt	...sKttluttIlcchWpLplpcp..lp............Gch.....lplp.................st.htLLhsp....sp.h.Lcsl..........................st.tt+lsspppps.tlpIpu.scushphlhpplsclhpslpopplslp.h.....t.pt...............p.....hs.pthL.splsphosshhcpsss..sst...lp..lpaht..................tsccss-hshRhLhhAh.s.tsp.ss.p.phhsphhs.............pstpuphhshss........................cshsWh-+..+pWhRah......................	0	13	41	71
+14463	PF14612	Ino80_Iec3		IEC3 subunit of the Ino80 complex, chromatin re-modelling	Wood V, Coggill P	pcc	Pfam-B_3771 (release 26.0)	Family	This is a family of fungal chromatin re-modelling proteins found in one of the chromatin-central complexes, Ino80. The function was identified in Schizosaccharomyces pombe but there is no orthologue in S. cerevisiae. 	27.00	27.00	39.30	36.80	20.50	19.80	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.57	0.70	-4.30	22	99	2012-02-03 15:55:25	2012-02-03 15:55:25	1	3	72	0	83	95	0	161.80	30	59.05	NEW	Y+SaKKKYtKh+IpF-.tM+-S-uLh+EEh+hp-huKRlpEQNDQLL-lLLEhNsSh+lPschRac...Luh..Pss..s.hhss..t...s...s.thhpt.Lp.u+sph.sGphp.pthp.lttshhpspsh.sPsh.phssLlp.VPHos.sstppp.....sDh-h.......sp.....shGFLoPEc-sEYhhshDu+lus.s...t.tphsp......pPshu.............p.-R-hslRNPsSVYNWLR+ppPplFLQDsE	.....................................................................................+Sa++KatK.+lhF-.tM+csptLh+p-.+h.shs+Rlt.pND...............pLL-hLL-hNpo.pls.phRhslsh..ssp.............................................................ts.h.phtpL.p.hPH.t.............p.p...................t..........s.sahss-c..pYhhthD.ths.................................t...t........................................ppph.l+NPsSVhNWLR+ptPp.hFLpDt-...........................	0	15	41	68
+14464	PF14613	DUF4449		Protein of unknown function (DUF4449)	Wood V, Coggill P	pcc	Pfam-B_1378 (release 26.0)	Family	This is a fungal DUF of unknown function.	27.00	27.00	27.10	27.10	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.83	0.71	-4.32	28	110	2012-02-03 16:32:29	2012-02-03 16:32:29	1	2	90	0	89	117	0	152.00	33	17.97	NEW	sVclcsLcIKlKKSpHKlLF.slFKPlLhpl..lRPulpKslEppIR-shp+sDuhhacl+pEAcRut-tucp..DPpp.ssNIYs+YhsAhpcchtpt+.cKAptt...ss....DpKlphAhTpc-SlFscIpLPGG..ISoKATEY+-........LAc+G-+.WESPlFoIGsAucSsslPp	.....VclcsLclKl+cSpHKlLF.slFKPlhhpl..lRsslpKslEctI+sshpphD.t.hhapl+pEAc+A...tctucp..sPpp....t.shascYhsAhppphhpt+.pcupth...ht....................-pclphshopccSlF.plpLPGG.....lSsKATEYc-........LAt+.....G-+...WcSPlFuIGpAtpSpslP.........................................................................	0	35	55	76
+14465	PF14614	DUF4450		Domain of unknown function (DUF4450)	Coggill P	pcc	JCSG:Target_393004-GS13576A	Family	This is a family of bacterial proteins of unknown function.	27.00	27.00	30.00	27.50	26.80	25.90	hmmbuild  -o /dev/null HMM SEED	211	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.54	0.70	-11.43	0.70	-5.19	8	86	2012-02-06 10:27:07	2012-02-06 10:27:07	1	3	47	4	14	68	0	154.60	27	20.87	NEW	MPshuGohRhGlssGscSpWlc-.hpKhcupa.hssp.hhhhps.......plplslhuLuDocGFIlElcucclP.-slsLhWuFGGssut....hscDsDIsu-st.......t.ChcNlaolcpssFTlhY.G.cuh......pL+s.......lsGlhPsto-IRLuDuctpsoPLpLapStKKossPVluu+hslsspp.........shYFshYp.psu+A-Ysha.hLspLFpKpcp	......................uGshphtl.pus.p.o.hhLcs.tpphcupahst+h.Y.l.c..h.ttGplpltshAhsDscGhIhchpsp....shs.c.ushLhWtaGsspst..phspsuDhss..p.......................................................................................................................................................................p.......................................................	0	6	14	14
+14466	PF14615	Rsa3		Ribosome-assembly protein 3	Wood V, Coggill P	pcc	Pfam-B_11864 (release 26.0)	Family	This is a family of 60S ribosome-assembly proteins, from fungi.	27.00	27.00	27.90	28.30	25.70	26.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.42	0.72	-8.10	0.72	-4.67	29	100	2012-02-06 14:52:56	2012-02-06 14:52:56	1	3	96	0	77	91	0	47.10	37	24.20	NEW	phpshYLphhsppFu-DL-pLR.pusDF.sspoLshLsps.LcpGsshFs	..phpshYLphhsppFu-DL-clR.pssDF.ss...coLslLscu.LppGsshFs..	0	28	52	71
+14467	PF14616	DUF4451		Domain of unknown function (DUF4451)	Wood V, Coggill P	pcc	Pfam-B_5126 (release 26.0)	Family	This is family of fungal proteins up-regulated during meiosis.	27.00	27.00	27.60	28.90	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.53	0.71	-11.22	0.71	-4.37	35	127	2012-02-06 15:39:06	2012-02-06 15:39:06	1	3	102	0	103	133	0	115.60	36	20.33	NEW	spsht.sDhYpPcalRspssp+.........pGhCshCt.........phhahshKsSuYh.aHhshpHGIsu.sGhhhssPpthtphp..p..............................cthp...............thpuhCt..pCpc....hlslps........t+...p.hhsaa+Htpc.pH	..........p..phpsDhYoP+alRspusc+...................EGhCshCc.........sscWLsLKNSuah.YchuasHGIou.sGps...att.Ppph+chp..........................................tpsp...................hh-GlCs..sCpc....Wlslss........sp...pthhsaaRHshcsH..................	0	37	66	92
+14468	PF14617	CMS1		U3-containing 90S pre-ribosomal complex subunit	Wood V, Coggill P	pcc	Pfam-B_3046 (release 26.0)	Family	This is a family of fungal and plant CMS1-like proteins. The family has similarity to the DEAD-box helicases. 	35.00	35.00	36.50	35.30	34.90	34.50	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.56	0.70	-5.31	5	248	2012-10-05 12:31:09	2012-02-06 17:00:37	1	7	211	0	174	236	2	221.00	27	77.70	NEW	TToscRKRpup....pcpuGKKcK.pt.........+RpK+ccRKcu-Lhpht.DVcuG....LNpAhA+MsPcLLADYlAsplKRFtoDLSSVELED+YIsASAIpDTTSFTKPRTLDNLP-F.LEcFSchssKLspusKoNGSPHTLlLTuAALRAADLuRulRKaQ...TKsscVAKLFAKHIKLcEpIoaLKsSRlGIAVGTPsRItDLl.-sESLoVDpLK+IVlDASalDpKsRGILDh+ETpcslhc.lLGpKplp-Rac..-cKlcVlFY	........................................................................................................................................ttpt.......................tp......................tptp.t..........p......t...th..........p...t.................t..p...........psp....h..-hh.tph.h.p..............t......h.......p.h.osl...ELp-h.............ls...........p.ss..h....h.......sssph..p........p.t...h.cs..l..ssa..l.c..t...h....s.......t..................p........l...........pt...p.....p...p...toPh......hlllssuulRus-lh.Rulpsap......stssplhKLFAKHhKlcE.........plph.L...............c.....p.....p.......p....sp....lulGTPsR............lpcLl...c.....p........s..uL..p..l..s..pLchlVlDhsahDpKtpslhDh.-h..p..lhc.hLt........................h..............................................................	0	52	92	139
+14469	PF14618	DUF4452		Domain of unknown function (DUF4452)	Wood V, Coggill P	pcc	Pfam-B_6056 (release 26.0)	Family	This fungal family has no known function. However, it is rich in paired, as CXXC, cysteines and histidines, but these do not fall in the conformation that might suggest zinc-binding.	27.00	27.00	49.30	44.50	25.00	23.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.15	0.71	-4.43	14	83	2012-02-06 17:08:27	2012-02-06 17:08:27	1	2	81	0	67	81	2	156.30	44	82.24	NEW	sHH....GGRsRRus+hSuupssp+QFR.GV+SM+-L.sEusulsuFRtRFEAuRSFDLEDDhEFCP.sLLTEsDLsSIpS.tuS-RSSLuSsSPpuSPtQp..ps.....ssuhSLsuuussh.sPsh.......pp..sthKlHQPuAsRsRNAIPIVNPsTGhshoSPPsSlsP.t.M........htRRW	....................................pt...ssRsRRss+huspps.p+QFR.....GV+SM+-L..sEusuloAFRsRFEAGRSFDL-DDhEFCP.sLLTEcDL.................pSIpS...tuS-RSSLuSsSP-oSPhQp.hps.....ssuhSLssu..o.ss.h.hsssh......pt....sth+lpQP.oAsRs.RN.A..IPIVNPsTG....hploSP.Ps....ShpP..................................	0	9	32	54
+14470	PF14619	SnAC		Snf2-ATP coupling, chromatin remodelling complex	Wood V, Coggill P	pcc	Pfam-B_4045 (release 26.0)	Domain	This domain appears to play a crucial role in chromatin remodelling for yeast SWI/SNF. It binds histones. It is required for mobilising nucleosomes and lies within the catalytic subunit of the yeast SWI/SNF. It is found to be universally conserved [1].	27.00	27.00	29.30	29.30	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.65	0.72	-3.81	109	470	2012-02-07 11:49:24	2012-02-07 11:49:24	1	26	242	0	281	441	0	79.00	40	5.41	NEW	pE....Rppp..ct.................................t.hs.RLhp-sELP-hhhp-tsth..............hpt-pptt.......GRGsRc.RK......p.VpYs.DuLT....E...-Q......WL	.............................................................................................................h.-Rc+c-t......t.........................scphP.RLMpE-ELPshhhcDcscl..............hppE--Ept......GRGuRp.RK......c.VcYs.DuLT...EcQWL...............	0	80	142	228
+14471	PF14620	YPEB		YpeB sporulation	Coggill P	pcc	Pfam-B_309 (release 26.0)	Family	YPEB is a protein that is necessary for the functioning of SleB during spore-cortex hydrolysis.	27.00	27.00	27.10	27.20	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	361	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.90	0.70	-5.44	62	303	2012-10-01 23:09:26	2012-02-07 14:26:29	1	9	272	0	84	258	0	334.50	35	74.40	NEW	hll.ssuhWGapppp.......c+sshphthpNpYQRAFa-LstpV-plcspLuKslsssSppptt...hhs-lWRhuutApssluQLPlsths...hscTpcFLuplGDFuYplut+shssp.sLocc-apsLppLappusplpppLpclpppl..hpsplc.Wh-.............lctth......ss..phppss........................sshlsstFpsl-cpl.ppYP.sl.a-GPh...S-ph.pcpsP+tlsG..plopc-ApphAppalshp.p.tphpsspssptsphssYshplts.tpptt...hhh-lo+pGG+llahlss..Rslu.........psp.lshscAhppAppFLpptGa..psMpss.stph.-........NhushsF..s.hppssVhlYPDhlKV+VALDsGcllGa-ApsYLhsHpp.Rsls	...................................................................h.llusuhWGYppap.......E+sslhhts-NpYQRAFa-LshpV-.LcsplupolshsSppphs..ssLs-lWRhoupApssluQLPls.hs...hscTpcFLuplGDFoYphuh+shptc.sLscpEacsLppLappusplpppLpclpphl..hpssL+WhD...........................lchshus...ptp.sc.........................ssllsu.hcsl-+sl.psYs..shta.GPh.......Ssph.pcpsshthpG..+tISc--AtcIAcpFlshp.......t.....s.....p......plp.l.p....p.....us.psuph.shYolplpstsppst.....hhh-lotKGGaslahh..ss......Rpl.p.............cp+.lSls-Ats+uhpFLcc...pta..psMphhpoppaD..............Nlulaoa..V..s.s..pssVhlYP-tIphKlALDsGpIlGFsApcYLhsHpc.RslP.............................................................	0	35	63	71
+14472	PF14621	RFX5_DNA_bdg		RFX5 DNA-binding domain	Coggill P	pcc	Pfam-B_20855 (release 26.0)	Domain	RFX5 and RFXAP reveals molecular details associated with MHCII gene expression.	27.00	27.00	119.70	119.70	19.50	18.60	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.45	0.70	-4.73	7	47	2012-02-07 16:00:39	2012-02-07 16:00:39	1	2	30	0	16	42	0	211.40	75	35.26	NEW	PGPGpAPPGGLTQPpGTEsREVGIG.GD.GPHDKGVKRTAEVPVSEASGQDPPAKAsKQ-hEDTuSDAKRKRGRPRKKSGGSGERNSTP-KSAAAh-SuQSSRLPhEsWuSutEus..uuuGsERPGssGEAEKGsVLsQGQtDGAVSKGGRGPuSRHAKEAEDKIPLVssKVSVIKGSRSQKEALpLVKuEs-susQGsKDLKGHsLQoSLs+E+KDPKAs	....PGPGRAPPGGLTQPRGTE.NREVGIG.GDPGPHDKGVKRTAEVPVSEASGQDPPAKAAKQDlEDT.uSDAKRKRGRPRKKSGGSGERNSTPpKSA..AAh-SAQSuRLPWETWGSGGEuN..SAGGuERPGPhGEAEKGsVLAQGQpDGsVSKG.GRGPSSpHsKEAEDKIPLVsSKVSVIKGSRSQKEAh..LsKGEs-TAsQGNKDLKtHVLQuSLopE+KDPKAT.	0	1	1	2
+14473	PF14622	Ribonucleas_3_3		Ribonuclease-III-like	Wood V, Coggill P	pcc	Pfam-B_6419 (release 26.0)	Family	Members of this family are involved in rDNA transcription and rRNA processing. They probably also cleave a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; they are involved in polyadenylation-independent transcription termination. Some members may be mitochondrial ribosomal protein subunit L15, others may be 60S ribosomal protein L3.	35.00	35.00	35.10	35.00	34.90	34.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.63	0.71	-4.18	70	4780	2012-10-03 08:45:47	2012-02-07 16:33:03	1	23	4550	5	1167	4144	2037	128.80	40	47.56	NEW	cppLLppALTHpSa....s....p.....t....p..p....p....p....NERLEFLGDAV...Lp..L....s.....s.oc..........a.l.a.cp............h.s.h..s..E.G.t.........h.s+hR.A.s...lVs.cp........oL.AphA.+clp..........LucalhL.....t+GEtt.psupsc..cs..ILuDshEAllGAIYLDtGhpsApcFl...tch...llssl	..............................................pLLppALTH.p.S..h...........s...............................t....t....t.................p.......p.........NER....LEFLGDuV...Ls.l.....l............l.u.c........................h.L...a.cc............................s.t...s...E...G.c.................................L.o+hR..A..s....l.Vp.pp..................oL...Ap..lA.+.chs...................................................Luch.lhL........................GpG...E.tp.....oG.G.p....c.+......sS............I.Lu..DshEAllGA.laL....D...p...G......h..p..s..scphlhphh....h.....................................................................................	0	402	757	987
+14474	PF14623	Vint		Hint-domain	Coggill P	pcc	Burglin T	Domain	This short domain is a conserved region of intein-containing proteins from lower eukaryotes	27.00	27.00	27.40	27.90	26.50	25.80	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.34	0.71	-4.75	14	51	2012-10-03 10:25:13	2012-02-08 11:39:37	1	9	47	0	42	56	43	164.60	36	22.29	NEW	sCFsGso.VpLuuscs.............l.........plcplRtG.pVhsPp....Gs..ccVtsVLpTsVpp..tplCcl...........G.sLhITPWHPl+h..tuc..WtFPsslu.....pscs......lYSlLL-ss.....HAlhV..sGhhsVTLGHGlpt.......pDltuHtaFGs.ppVs+sLttLsthtpG..hlhstuh..pRsst.TGhVpG	..................sCFsGps.Vplussps......................lplcpLRtGhpVhTPp....Gs..R+VtsVLpTsVpp...tslCpl...........................G..sLhlTPWHPlph..ssc...WhFPsshupt.s.h...sss........lYSVLLcssss...........spAHAlhV.....tsh.hsVTLGHGlps.........spDlRAHtFFGsYptVhcsL.tpLst.h...sG..llhstGh...Rs..oGhh................................................................	0	16	26	36
+14475	PF14624	Vwaint		VWA / Hh  protein intein-like	Buerglin T, Coggill P	pcc	Buerglin T	Domain	VWA-Hint proteins carry this conserved domain of around 300 residues, now named the Vwaint domain. Such proteins do not seem to have a signal peptide for secretion. Generally, this domain lies between the N-terminal VWA domain and the more C-terminal 'Vint'-type Hint domain. The exact function of this domain is not known.	23.50	23.50	23.60	23.50	22.20	23.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.82	0.72	-3.87	28	182	2012-02-08 15:26:40	2012-02-08 15:26:40	1	17	64	0	112	174	28	78.50	32	12.02	NEW	DptspuLhtDLpt...............QlphAhsspphYc+WG+pYLhSlhsAHshQhsssFKDsus..a.G..oshFppsp.............tphsshaDtLssPps	................D.hstuLhtELp............................chppth.....tsp.phYEppGRuYhLSuloSHuhQRs..su..Rs.Ds..........................os.h.hh.....................hphsshhc.l..sp..............................................	0	19	51	92
+14476	PF14625	Lustrin_cystein		Lustrin, cysteine-rich repeated domain	Coggill P	pcc	Jackhmmer:O44341	Domain	This repeated domain is found in proteins from lower eukaryotes in lustrin, perlucin, pearl nacre, and other similar protein-types. Each repeat lies between Kunitz-BPTI repeats, in certain species, which are also cysteine-rich. The cysteines may form the disulfide bonds observed for other members of this superfamily.	27.00	15.00	27.00	15.00	26.90	14.90	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.27	0.72	-3.88	56	1210	2012-02-08 16:11:41	2012-02-08 16:11:41	1	138	35	0	833	1225	0	45.60	27	22.43	NEW	ssCshG.pPhl.s.ssp.htC....sssss...CPssaaC.ahGss.ps.olCC.s	...............Cst.G..pshh.......t.ssp.shtC.....sspss......C.P.s.s..ah.C...p.....hu.ss.s...pp...sl....CCs...................	0	301	402	824
+14477	PF14626	RNase_Zc3h12a_2		Zc3h12a-like Ribonuclease NYN domain	Coggill P	pcc	Jackhmmer:O18125	Family	This family is found to be a divergent form of the NYN-domain- containing RNAse family.	21.00	21.00	23.80	22.00	20.80	19.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.66	0.71	-4.25	5	17	2012-10-03 20:43:45	2012-02-14 17:06:22	1	2	7	0	15	17	0	116.20	32	19.74	NEW	Y+ssLNLPVKALsDIIhhFLIRGHKTsVYLPKYY-Dalo-sGlSKVDDlVAFc................+Ll-LsaI..Kh..Ip.s.ca+WFNEVuchAD+sGAVFVSSsE.YRpRchclcYsKsSERIITPC.FLNA-DRLM	...............L.V+sLh-IllpFllcGHKTslaLPcaYpshhs...hpKVDDl.sFphLhsLchI+F...lpp...csccthhppVhtcA-+ssGlhVSssE.hhtp........................................................	0	5	6	15
+14478	PF14627	DUF4453		Domain of unknown function (DUF4453)	Coggill P	pcc	Jackhmmer:C9CWS7	Family	This short domain is found only on a small subgroup of proteins from Gram-negative Proteobacteria that also carry a YARHG domain, Pfam:PF13308. They carry three conserved tryptophan and three conserved cysteine residues.	26.10	26.10	26.10	98.00	25.30	22.60	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.46	0.72	-3.92	11	12	2012-02-14 17:36:03	2012-02-14 17:36:03	1	1	11	0	4	12	2	107.00	41	57.09	NEW	uC+VDTupppL..DlpDlthR.+pLhcLPlpD-hESAClGWhGsPlsLpAG+uh.soshIGpIpsGDslpauHhs..hGGWoYVola.ss.DWtlhouGWhc..hsths-pCspFAG	.uC+VsTppppL..slpDhthR.+pLhsLPlpD-hESAClGWhGsPlsLhAG+uh.soshIGpIpsGDsltauHhs..hGuWoYVosa.ss.DWtlhouGWhc..hsths-pCppFAG	0	0	4	4
+14479	PF14628	DUF4454		Domain of unknown function (DUF4454)	Coggill P	pcc	Jackhmmer:A8RR49	Family	This C-terminal domain is found only on a small subgroup of proteins from Gram-positive Clostridiales that also carry a YARHG domain, Pfam:PF13308.	25.00	25.00	97.50	97.40	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.78	0.70	-11.49	0.70	-4.71	5	9	2012-02-14 17:48:16	2012-02-14 17:48:16	1	2	8	0	0	9	0	198.90	40	43.06	NEW	caDcs+uctt.KpGY-uLPPAPYLsLLsc+sEhGVpLYSDluHAsD+GlYYsAcGTISVPloITsEQYculLs-GuElclVlNELTGEo+hL++ss.so-YG-s...hLlY-tGsEP.pssGE-TGtYh.loY-PsSGsYoLWssSsDTVFKTVYcGsVYVLKGA.........sEEaYsYFshP-+upsE..o..u.RVMpFs-.sshGssGY.sGNpLsaDuKGYlKAIYaLGD	...phDcsphctt.phth-sL..APYLphLscasEhtlpLhuDhspAhDhGhYYsspGoISVPholTtEQhps.httGuplclshsELTGEpthLphs..sschsth...hhha..Gp-s.ts.G.-sG....loh-.pSGpYpLWpsSsDTlhKTVYcGslYlLKGA.........spphYshhshsscupsE..s..u.hs.phst.ts.G.psh.hGNpLhasu+GYhpAlYaLGD	0	0	0	0
+14480	PF14629	ORC4_C		Origin recognition complex (ORC) subunit 4 C-terminus	Eberhardt R	re3	Jackhmmer:O43929	Family	This entry represents the C-terminus of origin recognition complex subunit 4 [1,2].	25.30	25.30	26.10	27.40	24.50	25.20	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-11.26	0.71	-4.93	87	326	2012-02-17 08:55:20	2012-02-17 08:55:20	1	17	258	0	210	324	1	202.70	22	39.47	NEW	hclscphLt.lssp...............................................tpphhptWNptlpp....Lhpsp.phpphLpphatts.+sh.....pphhs.h...hh..sl..splsssps............hlsssphh..........thsph.hsc..................phph.lpuLSsL-LsLLlAhs+Ls.thh-..............shNFsh.sas.EYpphhpptphp............................................psas+slsh.........puaE+LlphsLlhs............................t.ssststt-h.phhplplshppl.pslppt	........................................................h.plhpphLp.Lssc...............................................sptahppWNpplpp....Lhpsp...phpphLpphaphs.psh.....pshhthl................hh.......sl....spls..s.pps...................hlsssshh........pssphhp.D....................schph.lpuLSsLELsLlIAhp+Ls..cha-.............tshNFph.sYs.Eapchhpptptp............................................phat+slsh.........cAaE+LhphtLlhs............................ttsssphth-h.phh+l.ls.pplhpslt..h..................................................................	0	68	114	172
+14481	PF14630	ORC5_C		Origin recognition complex (ORC) subunit 5 C-terminus	Eberhardt R	re3	Jackhmmer:O43913	Family	This entry represents the C-terminus of origin recognition complex subunit 5 [1].	25.00	25.00	30.80	27.80	23.80	23.00	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.78	0.70	-4.94	68	327	2012-02-17 09:01:59	2012-02-17 09:01:59	1	12	261	0	243	309	2	262.10	25	53.50	NEW	lhFPsYo+cEhlpILtps..........tss.h.....................p.s.plaspFlshlhcshhsss.pclsplppls..cphWspaspPltsG.ph.....s..................tp-hs+Lapphpshhpp...thpslh..spphsss.....p.t............................t.t...............ttht........s.ss..s.p.....hcLPhhuKaLLlAAYLASasPs+hDtphFu.Ktp..u.....+p++.........p.pp.t...........................................................p......pp....tc...h...........................ssp..h...L..uPpsFsLERLLAIapuIh.....................s.p.t....ss..................................sss-......lhspluTLssL+LLsps..u.u.....s.................ssLD.u..sKa+sN..........Vuh..........-hltplA+uluh-lscYLh	...............................................................................................lhFP.Yshtph.pIL.ts................s.............................................p.s.phaspalshlhsshhtss.ps.l.pLppls..thhaspa...sp....Plhpsph.....t......................................p-h...p.+Lhpp.hps.hhpp...thp....plh...p...t.h.sstp.t.................................................t........t..........................tphp.......shts.ttp.............hpLPhhuKalLlAAYLASaNss+hDtphFs.+tps......................+p++p..ttt......................................................t..tp...tp..h....................................spp..h...l...sPcsFsL-RLLAIa.uIh...................sp...ss........................................................sss...lhtpluoLhpLpLlshsus.....t................................................s.h-.s.s+a+ss..........lsh..........-hlttlu+..s..lshpltpal..........................................................................................	0	72	122	203
+14482	PF14631	FancD2		Fanconi anaemia protein FancD2 nuclease	Coggill P	pcc	Jackhmmer:Q9BXW9	Family	The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.	27.00	27.00	27.30	27.10	26.80	26.60	hmmbuild  -o /dev/null HMM SEED	1426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.09	0.69	-14.36	0.69	-7.47	4	248	2012-02-21 15:25:38	2012-02-21 15:25:38	1	8	108	1	170	249	6	667.60	19	82.83	NEW	MlSKR+hScs-scEs.TEDuSKTchpshStcoKKS+luccsp......EN-SVFVcLLKtSGlhLKsGEsQNplAVDQlhFQKKLhQsLRKHPuYPplIpEFlSGLESYIEDp-pFRNCLLsCp.hpsEpu.ohusSYscSLIKLLLGI-ILQPAlIphLFEKlPEFhFEstspDGlNhPRLIVNQLKWLDRlVDGKDLosKlMQhlSVAPVslQHDIITSLPEILtDSQHu-VuKELusLLhQNTpLTVPILDsLSSLcLDsshLuKVRQhVMspLSSV+LEDLPVllKFlLHSVoAsDulEVIu-LRcpL-LppCVLPupLQASQsKLKSKuhA.SSSssQpoSuQsClhLlFDVIKSAIRapKTISEAWlKAIENhsSsu-HKVlDLlhLhIIaSTNo.po+KtsE+VLRsKIRpGCIQEQLLQssFpsHhhVlKDhhPSILuLAQoLLHS.DpsllsFGShhYK.AFphFDoYCQQEVVGALVTHlCSGsEuEVDsALDVLhELVlLpPStMhh.AsFVKGILDYh-NloPQQIRKLFalLSTLAFSQ.pppuuHIQDDMHlVIRKQLSSTV.KYKhIGIIGAVTMsG.MAtcRscssu..pcpusLSpEpssQVooLLpLV+SCoEpSPpAuALYYDEhANLIQcpK..LDPpsL-WlG+olhpDFQDsFVVDhssss-GsF.FPVKuLYsL-E.-TQsGIAINLLPLhhppp.uKsusphoutpSppRhVSPLCLuPaFRLLRLCstcQHsGsLEEIDuLLsCPLaLTDLEssEKL-ShStpERpFhCSLlFhTlNWFREVVNAFCQQssPEMKGKVLTRLpsIsELQslLpKhLAsTPsYVPP.AsFDsEohDhhP.SsoslsAKttpKtKsG.+KpKuDuSKsSSuDphptEcsS-s-.ssochucl.sKctstKEs.KohlpLpsY+sFFRELDlEVFSlLHCGLlTKhILDTEMHTEAoEVVQLGPAELLFLLEDhspKLEphLTss.A+RlPFLKsKGs+slGFSHLpQRSspEIspCVspLLsPhCNHLENhHNaFQsLhsENpGVVDtsslslQE.plMuSCYQpLLQlhHsLFAWSGFSp.EppsLL+SALpVLusRLKpsE.ps.PLEELlSpSFpYLQNF+pSlPSFQCALhLhpLLMsl.EK.usssspp+EKlASLAKQFLCpsWs..uG-KEKuspaN-pLHsLLsIYLEHTDslLKAIEEIuGVGVPELlNusKDAsSSTaPTLoRpTFlVFFRVMMAELEKoVKpI.sGpsuDSQplppEKLLhWNhAVRDFpILINLlKVFDS+PVLpVCLKYGRLFVEAFLK.sMPLLDaSF+KHREDV.SLLcThQLsTR.LHHhCGHSKI+QDTtLTpHVPLLKKSLE.hVhRVKAMLsLNpCpEAFWLGsLKNRDLQGEEIlSQs..S...pEusAE.-SE-shpSpAucsc	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t...............................................................................................................................................................................................................................	0	80	98	142
+14483	PF14632	SPT6_acidic		Acidic N-terminal SPT6	Wood V, Coggill P	pcc	pfam-B_9510 (release 26.0)	Family	The N-terminus of SPT6 is highly acidic. The full SPT6 protein is a transcription regulator, but the exact function of this acidic region is not certain.	23.30	23.30	23.40	23.40	23.20	23.20	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.86	0.72	-3.82	58	252	2012-02-21 15:38:02	2012-02-21 15:38:02	1	29	221	0	193	259	0	90.40	37	6.20	NEW	pDSSEE-.......----DEEEt+c......l+EGFIVD....-DE.......----p..pptp......c++++K++++cc+ctE--...tLDEDDL-LltENsGhttpp.........sKaKRLKRupc--	.................DuSEE-.......-p-DDE-ct.cp......................hcGFIsDp...-DE........E---t....pctt...........cpccc++++.++c.......+..........p.p.t--..........pLD-DDh-LItENhGsphcct........pKaKRLK+hpc-.......................	0	57	100	160
+14484	PF14633	SH2_2		SH2 domain	Wood V, Coggill P	pcc	pfam-B_9510 (release 26.0)	Domain	\N	27.00	27.00	31.50	27.10	23.90	24.90	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.36	0.70	-5.28	4	312	2012-10-01 22:44:06	2012-02-21 16:35:46	1	42	265	11	230	336	4	211.70	35	14.81	NEW	..+soYaDh-AEtcDscpEcc.pptpQRsphl+RVIsHP.F+slNh+QAEchhcoM-pGDlVIRPSSKG-sHLsVTWKVu-GlYQHlDVpE.tKENsFoLGpsLhls......opcapDLDEIlscYlQshAphhc-hhsHchF+c...Gs+KchEchL.chp+tpPsh.sYahshs+-hPGhFlLsapspups+lph..VplTPsGFhhpuplaPoVsuLhphFKshY	......................................................h......aD.ptE..t.t.D.p..c...p...cc.t.p.c.p.p.t.R......h.h.p.RVItHP.F+.shshppAEchLts...t...s..t..G-slIRPSSKGt.sHLslTWKVs....Du......laQ..H..lD..VtE..s..K.....-.....N....t.....a....olG+pLhl.s.......pppapDL.DEllscaVpsMuphlc-lhs.H.c+.a.pc...........Gs.+p..c....h..-..c..............hLpp.ppts.Psp.sYhh..sh..sp..c..hPG..h..FhLs.....ahs......ssp......s.+h..ph...VplhP..cGac..h....p.tp.........asslptLhp..hFKph......................................................................	0	79	131	193
+14485	PF14634	zf-RING_5		zinc-RING finger domain	Coggill P	pcc	Jackhmmer:Q495C1	Domain	\N	27.90	27.90	27.90	27.90	27.80	27.80	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.55	0.72	-4.23	118	801	2012-10-03 15:03:13	2012-02-21 16:43:03	1	78	214	0	571	6385	343	47.50	29	12.65	NEW	pCs..hChpth...............ppt....hhlssC.uHl.hCp..pChpptt.................ttpCPh..Cpp	....................................Cs..lChpph........................t.ppt............shlhs.C..uHs.hCp..pClpphh...........................ttphpCPh..Cc..................	0	166	222	455
+14486	PF14635	HHH_7		Helix-hairpin-helix motif\	\	   	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-10.25	0.72	-3.91	4	299	2012-10-03 02:11:09	2012-02-21 17:03:10	1	47	257	2	231	2357	68	104.10	41	6.91	NEW	-DlhsLphHPhQchlspEpLhpAL.stFlshVN.VGVDVN+AlspsYptullpYIsGLGPRKusalLKhLppsNsRL-sRoQLlThshMu.KVFhNCAGFlhIs	.................................c-IlsLph.H.P.hQp.h.ls...p-cLhptLcpthV..shVNt........VGVDlN..cAls.......c.sap.sslLpaVsGLGPRKAstLl.......K.......hl.p..p.s...s..stlp.......sRppL....ls.........h......s......hhGs..+VFhNCAuFLpIp...................................................	0	87	136	196
+14487	PF14636	FNIP_N		Folliculin-interacting protein N-terminus	Eberhardt R	re3	Jackhmmer:Q9P278	Family	This is the N-terminus of folliculin-interacting proteins [1,2].	25.00	25.00	25.70	29.30	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.96	0.71	-3.68	40	205	2012-02-22 08:14:46	2012-02-22 08:14:46	1	9	140	0	136	194	0	126.80	33	11.18	NEW	plRlllhQ-sptcspp..lLFDSpsspphspsssss.st..s.......................tsphspttt...hpssssp..............shttp.p....hpspsppsthpa.t+....ssDlshL.u-hlFGSss.MuY+G.oohKlHhls...us.sphhhopsh	.........................................plRlIlhQDsppcscp..lLFDSpshp+.spphs.spphs.sss....................................................sphsp........ssssp...............................puhpsosss......pscpptsc.aphsRs...usDsshL.uEMhFGSlA.MSYKG.SohKlHhlp...oP.splhhopl.......................................................................	0	27	49	88
+14488	PF14637	FNIP_M		Folliculin-interacting protein middle domain	Eberhardt R	re3	Jackhmmer:Q9P278	Family	This is the middle domain of folliculin-interacting proteins [1,2].	25.00	25.00	27.10	26.50	23.70	21.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.54	0.70	-4.78	17	166	2012-02-22 08:15:25	2012-02-22 08:15:25	1	9	87	0	101	150	0	226.90	48	22.26	NEW	ptsstssppsssht++t+lulullhpl...........s-sptpph......cpFhhpHhsllEochs+L+stlcp..............ushptptalphlhpAhpch.pphlssLaou........PRlppPVWLshho................sppppplspcFhppLspLlpphsp+popaFlSsLlTAVLTaHLuWVsTVtsssts..........p.hh.hp.ppplsplspsaPY.NsLWAQLuDLYGulG..............sPs+Lu+TlVsGspp...llp+lL.lLSYFIRCSElpc	...................................................................................sh.st-osusssuhlR+KKIAIulIFSL....................scp--tpp.........pFp-FFFSHFP....LFESHMN+LKSAIEpAMh.......................p+hutsu.php..hhh.sRlh-ALsEF.RsTIpNLYoh.........PRIsEPVWLTMMSu.........................................o.EKspLCpRFhKE.FshLhEphsKNQ...FlsALlTAVLT.HLAWVPTVMPsspP........PI+hF.EK+oSQSVshLAKTHPY.NPLW.AQL.G..DLY.G..AIG..............SPVRLuRTVV.VG+cp-..hVQRlLYhLTYFIRCSELQc........................	0	30	38	64
+14489	PF14638	FNIP_C		Folliculin-interacting protein C-terminus	Eberhardt R	re3	Jackhmmer:Q9P278	Family	This is the C-terminus of folliculin-interacting proteins [1,2]. This region is responsible for binding to folliculin [1].	25.00	25.00	29.90	28.70	20.10	21.00	hmmbuild  -o /dev/null HMM SEED	192	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.57	0.71	-11.25	0.71	-4.95	16	160	2012-02-22 08:16:55	2012-02-22 08:16:55	1	7	88	0	99	144	0	183.60	49	17.82	NEW	clPhPpsp.hp.s.s...............shuRSLhuGhs-sYsPDFVLpG..hsssc.hcpp.....................LtsD........LthusppSsl--s..luEuVsIlADsDsWsVplhSSpppshs.......uh.VusSplVs...........uMLpShhsLachshssp...FClhaLED+LpElahKScsLuEhL..............pssst.lshcclspsLGl-tuDlPLLluVAusHoP.Vs	........................................................lPhPt..Sp.lpsptst.s.t............NFG.RSLLuGYCsoYsPDhVLpG.husD-+.h+Qs...........................LhuD.....LsHuVpHPVLDEP..IAEAVCIIADhDKWoVQVASSQR+ss-..K.............LGp-V...L...VSSlVS...........sLLcShLQLYK.h.sLsss...FClMHLEDRLQElYhKSKMLoEYL............................................+GphR.VHVKELusVLGIESsDLPLLsAlASTHSPaVA........................	0	26	34	62
+14490	PF14639	YqgF		Holliday-junction resolvase-like of SPT6 	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	The YqgF domain of SPT6 proteins is homologous to the E.coli RuvC [1] but its putative catalytic site lacks the carboxylate side chains critical for coordinating magnesium ions that mediate phosphodiester bond-cleavage [2]	35.00	35.00	35.00	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.64	0.71	-4.65	4	495	2012-02-22 14:01:54	2012-02-22 14:01:54	1	42	441	2	270	514	14	143.20	28	12.53	NEW	pGKh.+VLuluhupGR..scslhCshVNscGEssD.L+L........shc.c-+ppptp.hEsLcpFl.spKPcVluVuG.NhcAphlhcclpcslpch-..spph.slsl.hV-sElAlLY.NSc+utsEF.shPPll+.sVuLARhlQsPLlEaApls	..............................................h.....................sh.h.h.shlctsGcll-phpl.....................................h.s...t.psp.p.p...c............p...pshpp...L....t....ph....l.p...p....+.csclIul..s...G.t.u.t...cop.c..l....hcclt....c.......h...l......p.........c...........h..............p....................t..............t.....................p...................lt.......l..hlVs-psAplYpsSchAtpEFP..c.h.s.s.hlRtAVSlARpLQDPLsEhs...t.........................................	0	95	154	231
+14491	PF14640	TMEM223		Transmembrane protein 223	Coggill P	pcc	Jackhmmer:A0PJW6	Family	\N	22.00	22.00	22.30	22.20	21.90	21.80	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.93	0.71	-4.32	14	99	2012-02-22 14:08:19	2012-02-22 14:08:19	1	4	75	0	62	100	0	152.60	31	73.24	NEW	+DVlLFca-ps+FF+hLslFuhsQhhFWsYLuaFu..ho.....cs.ss.p.c.ppchshhptl...............s.LupspaR.Glshhs....lhlGshlLhsuhhFoLRSVptllLp+GGppVolhTYuPFG..ppRthsVPLcplSshtsRpps..pu.lPlKVKG+tFaalLD.pcGcFpNspLFDhTVGlpRp	.......................................................................pDlhLaca..cps.+FathlshFshsQhhFWs.huhhu.hs.........ps.s..........tc...ht.h.................s.htsshaR.Glshhs....hhhGhhlL.hssh..h..FshRSVp.lhLppGGp.....p........VslsT..auPFG...h.tpph.s..........V.......PLppVSsh.spRtps...s.lPlKlK...G+p....haalLD..+tGcF.NspLFD.TsGhhR............................	0	23	30	44
+14492	PF14641	HTH_44	HtH;	Helix-turn-helix DNA-binding domain of SPT6	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	This helix-turn-helix represents the first of two DNA-binding domains on the SPT6 proteins.	35.00	35.00	35.20	35.30	34.40	34.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.59	0.71	-4.12	4	227	2012-02-22 16:49:36	2012-02-22 16:49:36	1	29	207	2	176	238	0	131.10	33	8.87	NEW	LpshsshsuEDDELEEpstWIhcphhss.shshptsh........hosFp.......ptI+pAlpFhpppphEVPFIhhYR+-Yl..........pP.Ls.NDLWclaphDpKappL+s+KpslpRLapchph..........DcPLs	.............................................h.hp.-..-..ELc-EApWIhphhhsc.p.s...hs.h..ppsh....................ppsFp.....................ptItcsLcFhp..spphEVPFIhhaRK-Yl...........................................................................c..............Ls.hsDLW+laphD.KappLhp++psLp+ha-p.hpt...............h........................	0	58	92	143
+14493	PF14642	FAM47		FAM47 family	Coggill P	pcc	Jackhmmer:Q5HY64	Family	The function of this Chordate family of proteins is not known.	27.00	27.00	27.70	27.40	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.90	0.70	-5.09	2	239	2012-02-22 17:41:02	2012-02-22 17:41:02	1	10	33	0	65	246	0	127.20	33	63.46	NEW	MGDpRPQDRPpS.GMDSpPWYCDKPPSKYFAKRKHRRLRFPPVDTQNWVFVTEGMDDFRYuCQSPEDTLVCRRDEFLLPKISLRGPQAD.KSRKKKLLKKAALFScLSPsQPARKAFVEEVEAQLMTKHPLAMYPNLGcDMPPDLLLQVLK.LDPERKLEDAhu.CEupEKTT-.PTEsGKYPCGE.sPRPPET.VSpL.Pp.PKTPVSShRPEPPcTtVSpLRPpPPKTpVSSLH.EPPETtsSHLRs-PPcTtVSp	........................................................................................................................................................................................................................................................................................................................t....hsp..........t...sps...hS.p..Lp.E.P..Pc...T.t.s.SpLp..EPsco......s.Splp.-P..c...t.h..s...........................................................................................	0	28	30	38
+14494	PF14643	DUF4455		Domain of unknown function (DUF4455)	Eberhardt R	re3	Jackhmmer:Q9P1Z9	Family	This domain family is found in bacteria and eukaryotes, and is approximately 480 amino acids in length. There are two completely conserved residues (W and P) that may be functionally important.	28.40	28.40	29.00	28.80	28.30	28.30	hmmbuild  -o /dev/null HMM SEED	474	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.30	0.70	-12.31	0.70	-5.86	16	121	2012-02-23 13:51:07	2012-02-23 13:51:07	1	10	67	0	82	82	0	353.80	27	33.39	NEW	ht-s++c+appslsuhpc-hsplup-hEstltcsutthhpplucsDpplsplhspl-s-ssLhchohppLhpla-pVsp.ch.h+pphIcpL-psLpphEppRt-pLcssLc+hhptLpchualhps-VpRhlscEAMtlNpslLtNRRAhAcLhhpLhpsclcpEtspctcWppthccW+sL+ppphlppFp-hhtStchtsPsphpphhEshtcpQtslpppRhchlpslsslhP................Pshopsp....lpcWhsslpslscph....sphptpthtcl+tph-csppcshsplpph+ppLhphts..hsp-ctpsLVstchh.hssphpppscchLEthcphhEphutphcppspsLhpahpclspha-tHppthtpp-t-lppclcptRppasppppppEspLDthlcplpptusEpsLctplcpshshLcplcppYcsF+pphsplsppYPstlhpphpsYppsLsphhtlcchhcpshtsph	.................................................................pppta.thh.th.ppht.ls.php..hhp.tt.h.t.l.p.stthp.hh.thttp..h.thphpt...l.plhppltt.....ppp.IcphcttLtphE.pRhppl...pthLpchsthlpchuahh.s-l.+llppcuh.hNtslLuNc+uhupLhhpLhpsplpp-h.ptphc.WpthhpsW+tlp+pthlppFpphhts.tphppP.th...............p........hpthhppQ..lt.p.pRhph.Lpplp.shhP......................................Pshspsp....lpcWhpplpslppph....sthphphh.pl+h.h-phhppsht.hpph+......ppLhphth....h.spcchpphlp..h..h........hhtthttphct.lchhtp.h-t..ttp.p....tplhpahtthsthh-.pt...h...p.ph.pphtphptt.p...t..ctthp..htphp.tsp.tttLt..ht.s.t.Lt.hp..h.............t.................................h.................................................................................................	0	37	50	60
+14495	PF14644	DUF4456		Domain of unknown function (DUF4456)	Eberhardt R	re3	Jackhmmer:Q9P1Z9	Family	This domain family is found in bacteria and eukaryotes, and is approximately 210 amino acids in length. There is a single completely conserved residue E that may be functionally important.	25.00	25.00	25.10	26.80	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.40	0.70	-10.93	0.70	-5.10	19	84	2012-02-23 13:52:56	2012-02-23 13:52:56	1	8	59	0	55	72	0	181.90	26	14.14	NEW	hhshs-.aYcpct.p+tlsRPppl.psh-phs-slppplpph.pppupcappsslpchRsQlpphpphhpplsthlhpshhppahpphppuhpslppc.Fpph.pphppp+pp+tppLRPsLucPsphpELcsLpppEpcRppch.phlpphpptlh-sttp.uptFlppLsphspphlhhhD.phlhh-Dltssshssspp+pthhhpp+h	.....................hths-taacpc..pc.hptPpth.psh-pss-tltptl.ph.pppsppYtspslhchRtQhpphpchl............spl...........s.llhpshhppphpphppshpplptp.Fpp..pphppt+ppptppL+ssLu+PtphpphcsLpppEppRppch.phlpt.pptl.cphpp.uphFlspLsshscphhh.LD.plloh-Dltssphts.ppphphhhppc.......................................	0	30	38	46
+14496	PF14645	Chibby		Chibby family	Eberhardt R	re3	Jackhmmer:A6NI87	Family	This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila [1].	23.00	23.00	23.70	23.30	22.00	21.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.34	0.71	-4.20	14	172	2012-02-24 08:43:10	2012-02-24 08:43:10	1	5	85	0	109	173	0	115.10	33	58.82	NEW	MPLFup+...FSPK+sPhR+suShSsh.pslDppTcphEhuhsaGssphcLu.spplhF..csGpWh.........s.us.sssssspcst+L+KcsppLpEENNhLKLKh-lLLDMLoETTA-sHLhEKEl-	..................................................shht.p....Fus+phP.R+.tS.ssh..psh-+soc.p.s-LtL-.Y.ssPphpLu.spphhF..psGpWl..............................tp.u...ptssstc...-spp.L+ccsptLcEENNhL+lch-lLlDMLsppss.c.p...................................................................................	0	25	35	60
+14497	PF14646	MYCBPAP		MYCBP-associated protein family	Eberhardt R	re3	Jackhmmer:Q8TBZ2	Family	This family of eukaryotic proteins includes the mammalian MYCBP-associated proteins. These proteins may be synaptic processes [1] and may have a role in spermatogenesis [2].	24.50	24.50	24.70	24.70	24.30	23.90	hmmbuild  -o /dev/null HMM SEED	426	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-12.34	0.70	-5.76	34	181	2012-02-24 13:32:21	2012-02-24 13:32:21	1	5	93	0	112	180	2	330.40	21	48.95	NEW	ss.phDpRL+pWpchLppR++hQp+lp+chGKpss-lLhNpssTl.....Rsppph.....+cllD...hsp.Psp..ppcs.....hp.hu....thhpp..p.phspp......lstLt.ThP+sEctt..slE.hlGLPpss.ppElhu........p......tptphpspWp+..SphLppRlcctppslccllp..ah..PDl-..sLpV....lGps..h.......hpss..................pspphph.pps.........................ppt...spp-ph..pp...sth....pp..ps.c.....s..p...sh....ps......ulph....supsh......hhh.s....tssp.p.....................tphshthplhFcC.......cPhp.+s.h+tlh.lcNlGspslphpWpphshhtpht...........s..hhhspspcFhF-ppshhlhPGEs+phplhFpPppsulhpppWc..Lp.h.pPslhu................ppt.lhl..pL....pGhChssspatp+hpchpptlhsKpppphsppL..h..pch.....LssllpPspsh......CPY.-RhlsEcElFsstN....PG.a+....s.R.a-DLEsL+pLapplK	............................................................................................................................................................................................................c.hLp.Wpp.ht.ppt.pttlt.phht+.sp..phlhp.spph.....Rphtp.hphh-...h....h...........t..s.....hhp...................h.th...sh.sphp.......l.p.hhths..h..p..Eh.h.........................a.p..S.hL..+hpp..t.htpl..........s..hs..tLpV....hGps.................................t.tt....t...........................t......t..tt............t...................t................................t....sh.h....ts..h..................tt.t......................t.s..h.plhFps.........hp.ph.pplh.l.N.GshslhapWpph......t.....................................................p...hh.s.p.ppFhF.sp.p.thhlhPGchpphthhFps.psG.lhpphWphts..pP.lhs................tt...h.lpL....huhs.h......h..tthp.hpp........h.tptt..hhppl..h..pph.....l.sl..s...s.......s.Ph.pt.hpcp-hFt..N.....t.h......h.p.t.h..l.tha..............................................................	0	45	53	80
+14498	PF14647	FAM91_N		FAM91 N-terminus	Eberhardt R	re3	Jackhmmer:Q658Y4	Family	\N	25.00	25.00	27.10	26.00	22.40	23.40	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.75	0.70	-5.37	14	179	2012-02-24 15:46:41	2012-02-24 15:46:41	1	12	117	0	114	165	0	259.20	44	36.29	NEW	ptIRpNhsWppLPssl+ptLGsSp+-Y-KtVlcYS.l+sQLRa+sNlV++lt+cEcpYY-cLlcYSpppLhLYPYHLuDlll+tLRlTPFsYYhsllsclLpsE+SYDuLPNFTAADCLRLLGIGRNQYI-LhspsRSs.......+phFt.++ss+chLPppPl.hth.-PWWhVpsGhlhEsDl+h....Lo.tE+shlDpLIDpGsp.....................h.AGpLchslVpuLYpKGLlYL-VPlss-DhIsVPPL-G.FVMNRV.GDYFEsLLYKIFVolDEpToluELAplLplDlppVKsAlSlaCRLGFA+KKs.sslsp.......spl..HsSWts	...........................h.tlcpphsWppLPtplpp.Ltsopc-Yc+pll.Yu.l+ppL.cacssh....sp+lhpcEpcYYEcLlcYspppL........hLYPYHLu.....Dh.....hs+shRlTPFpYYhslht.....-lhpsE+SYDoLPNFTAADsL.RllGIGRNpYI-lhNpsRSp.......+.h.h....h....h.........+p.hs+-hLPhpP.lchsl.EsWWhlphs.lsp--l+h....ho.tEtshl........Dcllcpss..p....................................................................................................ss.h-hpllpuLYp+GhlYhDVPlps-s.......plt.VPsL.EG.FVMNRs......p..s......D.hEsLLY+lFVohDEp.ssVuE..............LAphL.......plDLp..lpsAlShhCRLGaApKc.............................................................	0	41	62	89
+14499	PF14648	FAM91_C		FAM91 C-terminus	Eberhardt R	re3	Jackhmmer:Q658Y4	Family	\N	25.00	25.00	33.10	26.90	23.90	23.50	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.63	0.70	-5.65	9	246	2012-02-24 15:50:15	2012-02-24 15:50:15	1	12	117	0	173	235	0	274.80	26	51.76	NEW	s.sKRIAFLFDSTLTAFLMMGNLS..PsLKsHAVTMFEVGKLSDESLDSFLtEL-+V-p.suEGEAQRYF-HAlTLpsTlLFLRpscclh.p.s.Pc..shshulDLLRsESL.uLDssTpSRVLsKNYpLLVSMAPLStElRslSs.ssPsHhGPsIPEVsSsWFKLaLYphhGpGPPSLLLsKGoRL+plPslFpca-+LLlTsW.......................GHDsulVssSNsLlhLNDALoHSAVhlQuaG.hhsp....u-..............olplPFPFpcs-hth...Fohsphph.H.ulppLcpplsLpa.pCGYlThLs......tspph.tst.......st.ttsthpsshs....ht.t.poFshstc...pth........ss.uppp.pptsssps-Wh.L-lsFGlPLFcu-LNpclCc+IsuppLhpc-slpplhpusRcLuhplhpFlppaQshspssc.pst...su....lspss..........ttuslPhPspsLlFcsGcLs.W-	....................................................................t............................................................................................................................................................................hlp.tth......t..ph..htY..hh..........................h.......................h.h..........t.s...............shhh.hG......h..hP..h.............t..ph.....h.......................t.p...hh..t..h..hNp.h..tslhlp.h.......................................................................................................h.s........................................................................................................................................................................................................................................................................................h...th.hGhs...l.t..hs..hh..h...th......................................................................................................................................................................................	0	57	98	136
+14500	PF14649	Spatacsin_C		Spatacsin C-terminus	Eberhardt R	re3	Jackhmmer:Q96JI7	Family	This family includes the C-terminus of spatacsin.	25.00	25.00	25.70	27.80	24.80	21.80	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-11.89	0.70	-5.54	28	154	2012-02-27 09:55:58	2012-02-27 09:55:58	1	4	102	0	95	154	0	263.60	33	14.19	NEW	ohlGppLl..................ch.spu......................................................s.........pct.p...........hsshVELLIp..AHpCFstsCsh-GIspVLpts+phs.shLspspcasLlVRLloGlucYpEhpYlFDlLlcscQFEhLLp+.p..h..........Dp.......t........sG.......L+hAlLsaL++hpPp-p.-taphlsL+FsMa+ElAphhcpcAc.ptl.chlts..............p.s...............p............ppsphpppL.p.uhcpahcAA-sYhp-sshphAppCsppApLluLQlclh...............................ph...pllsLs................csphcchlspphsF.pALIlAcAYsh..pssWupsLapQhlhtGsh.pYLp-Fhphhslssslhp-ls+pYptc	.........................................................lG.tLhch.h.s..........................................................s.......ph.............hps.sELLIh..AHpCFshsCph...-GIh..plLptsphhs.sths...spcauLllRLLoGlucap-hpalF-lLhcpc..FEhLhp+.t............-...........ts....l+hAlLsal++h.pPtDp.-tashl...........sLpFsMh+Elu.p.hEstAp.tl.chl.s........................p.s............................ps.phpp.LhpuhphhhcAAEsasp-sshppAp+stphspLlsLQl+hh.........................................................sh.hllsLs................cpphhchlhthspF.pA.IVAcAYs.h....s.s-Wu...plLapphlh.ssh.pYLpEahp.h.Lpsshhp-ls+hap.............................................................................................	0	35	50	71
+14501	PF14650	FAM75		FAM75 family	Eberhardt R	re3	Jackhmmer:Q63HN1	Family	\N	24.00	24.00	24.80	24.40	22.40	23.60	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.35	0.70	-12.21	0.70	-5.07	23	316	2012-02-27 11:20:10	2012-02-27 11:20:10	1	7	25	0	203	266	0	228.50	24	29.28	NEW	Qphsas+shpD.pLppKssQLFWGLPSLHSESLsusshlssssSshp...hlFNchSss.Ph..psphos....................hLopspPLshsphQsQs..hh.shPQ.Qs...PlsphpsQApLpsslPlls....PSs.sQl+sCGVsa.ssQscspsLhPoEIppLEaslLpKQ.EpthsLPolVc+SQcsFs.ssPshspcs.....ts.psphssSIhPssFslosEL+++LEpHLpK+lIQcp..WGLPpRIpcSlplhpPQsEhstsspucuppG.....sSp.ShhpucuspsspK.st...stp........hphcpchs+.shspsltph.KDhsts...psossscl.tsssEpphps...........t..pscstts..hu.s+ccLEssLcsHLs+KhspIsEG.lPsoV+pSh	.............................................................tp...phFhGlPshpSESl.s.h.........h......t..................................................................................................................................................................h..t.p....t................t...p...th....+t.p.....hsshhpp.....t................p...................................hshhst...p.h...h...c.h.pp..h-.+lpc.hh....p.p...s.st+lp.S.ph.h.........t....t..................................................................................................................................................................................................................................................................................................	0	20	20	30
+14502	PF14651	Lipocalin_7		Lipocalin / cytosolic fatty-acid binding protein family	Coggill P	pcc	Jackhmmer:P51161	Domain	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2).	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.78	0.71	-4.42	3	209	2012-10-03 08:47:39	2012-02-27 14:48:16	1	2	77	40	108	690	0	119.60	38	94.68	NEW	MAFTGKYEhESEKNYDEFMKRLGLPSDVIEKARNFKIITEVQQDGQNFTWSQpYSGGHoMTNKFTIGKEC-IQTMGGKKFKATVQMEGGKVVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA	................MsFsG.p.aph.p..op.ENa-tFhKs..l..G...lP..p...-.h..I..p..+...u..+..shK..slo.Elp.Q.sGpcFsh.ot.....h.s..s.u.+..s..h.s.N.p.FT..lGc...Es..E..hp.T..hs..Gc....KhKss.....V.ph.EG......s....K.......L.....V.....s........s...h.............s......h.......p.......p........s......p......E....l.....s.....G....s.p..lsp...s...Th....u...sh....sh.RhSK+..........................................................	0	29	39	68
+14503	PF14652	DUF4457		Domain of unknown function (DUF4457)	Eberhardt R	re3	Jackhmmer:O60303	Family	This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.	24.00	24.00	25.60	24.30	23.60	23.60	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.96	0.70	-5.47	14	419	2012-02-28 08:56:53	2012-02-28 08:56:53	1	6	92	0	292	386	5	183.50	19	50.48	NEW	plplhpoWGDtaYlGLTGlEl.....l.spptp.lslshpplpApP+DlN-lssapsD.RTLDKLlDGhNlTT-DpH..MWLlP....as..tpcphlsIchsptpsluulRlWNYNK..Sh-.....DoaRGsKhlpl.lDsph.lss...........ssallRKAPGs.spFDFuQsI.h.phppp...........pshp.hsphpt.h...............h.........pp-YpsshhPsGalh+h.LloTWGD.aYlGLNGlElaDtpGppI...plp.psls..AhP.SVslL...shpsDsRTs-+LlsGlNs.TasspHMWLu.........Phhsu......................psNplYlhF-pPlslShIKlWNYSKTPpRGV+EhtlalDDlLlYpGhLcpssp	..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................s................h..h.h.hpsaGs.....hultthphhs.......................................................................................................................................................................................................................................t.......................................................................	0	118	148	223
+14504	PF14653	IGFL		Insulin growth factor-like family	Eberhardt R	re3	Jackhmmer:Q6UXB1	Family	This family includes the insulin growth factor-like proteins. These proteins are potential ligands for the IGFLR1 cell membrane receptor [1].	25.00	25.00	26.50	31.60	24.00	24.50	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.01	0.72	-10.83	0.72	-3.97	9	151	2012-02-28 09:38:21	2012-02-28 09:38:21	1	5	23	0	106	129	0	68.80	44	82.70	NEW	hs.u.ssschhhCp.hPRCGc+hYNPhcpCCscssllsLs+T+h............CG.sCTaa...PChchCC.tphs.spp+aVVKLKshGhpu.p..sPloppC	.................u.hhPchh...hC..hPRC.Gc+FYNPhcapCscsphl..s+T+p............h..................................................h.......................	0	74	74	74
+14505	PF14654	Epiglycanin_C	Mucin_C;	Mucin, catalytic, TM and cytoplasmic tail region	Coggill P	pcc	Pfam-B_ 91014 (release 26.0)	Domain	This family represents the non-tandem repeat domain including cleavage site, the transmembrane helix domain, and the cytoplasmic tail of epiglycanin and related mucins [1].	22.40	22.40	22.50	36.30	21.30	21.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.52	0.72	-4.03	5	31	2012-02-28 11:02:14	2012-02-28 11:02:14	1	10	13	0	14	32	0	100.60	66	14.78	NEW	SAoTPVsEsKPSGSLKPWEIFLITLVSVVVAVGLFAGLFFCV.RN.SLSLRNsFsTAVYaPHG.N..LGs..........................GPGGNHGssHusuWSPNWFWRRPsSSlAMEMpGthsRP	.........pAoTsVSEsKPuGSLhPWEIFLITLVSVVsAVGLFAGLFFCV.RN.SLSLRNsFsTAVY+PHGhN..LGs..........................GPGGNHGsPHRPpWSPNWFWRRPVSSIAMEMoG+tsG.P.	0	6	6	6
+14506	PF14655	RAB3GAP2_N		Rab3 GTPase-activating protein regulatory subunit N-terminus	Eberhardt R	re3	Jackhmmer:Q9H2M9	Family	This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily [1].	25.00	25.00	25.20	25.10	24.60	24.00	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-12.42	0.70	-5.47	21	180	2012-02-28 14:10:59	2012-02-28 14:10:59	1	8	138	0	125	175	0	330.20	31	32.33	NEW	WL.ssssl..ulussu-hlslAtsp+hslLsstW...pps.stsshthshpusl-sts....ppITulphlPhsstt..........-hsslulGhoSGalhFYoppGsLLhpQhhp.pcsllpl+l+ssppht..t.........cELsllYP.sslshIsGhsLhshLpsshppls+sthstpt........sts.ssLsapKWsh..scts...slsDsulsGshhsshF-.h.............h.ppos.phsphlssGscPhluaahspE.Gtspslluslhp.uVuuploohl.........huhh...uts.pppppssppp................ps.sshssRhsLhDttRcGpslsluPs.spLAAlTDsLGRVlLlDstpslllRlWKGYRDApCuFlpshpcpsp............sppscpchu..............................LFLlIaAPRRGlLEl.Wshps.GsRVsshss.uKss+Ll	.........................................................................................l..t..h...hs.t.phhshu.ttp.hhh...h...............h.h.h.t.hp.............p.louh.hlsh.t.t.................-.hhslslGhssGhlhhaot.tG..hlhtphh.............p..p.lhtl+hps..h....................ppl.llas.sslshlpG.slht.Lptthppltpst...htt..............s.lsapKath..pp.s....h.Dts....h....G...h...s.a-.h...........s.h.pto....s.thsphlssGtsPhhuhahs.E..s..tsp...sh.lucls.h.uluuph..sshl...............................tuhh..u.ht.tppppps.sppt.t.....................pss.sshs.s+h..sL..DscRcups..lsluP......s.s......p.LAAl.T.DshGRVhLlDstpslslRh...WK...GYRDAphuWlphhpphtc..............................t.t..pchu................................................................................................................................................................................................aLlIYAPRRGllEl.Wshpp.GsRlsuhsl..u+tspLl..............................................	0	51	69	103
+14507	PF14656	RAB3GAP2_C		Rab3 GTPase-activating protein regulatory subunit C-terminus	Eberhardt R	re3	Jackhmmer:Q9H2M9	Family	This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily [1].	25.00	25.00	27.30	26.60	23.70	23.60	hmmbuild  -o /dev/null HMM SEED	595	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.94	0.70	-13.12	0.70	-6.38	9	135	2012-02-28 14:11:58	2012-02-28 14:11:58	1	6	90	0	89	126	0	456.10	34	43.64	NEW	cDLLoLllsaWLpKshchhpps...-shscltphlphLschtush-p..sashpslSPWWQplRchllpScph.uuLLsAlVs+sVAsphh....cstp-tp..hspsshtss....pEpWEplShDtptWsLLhtpLEDlhlLtslLsps....hssppshssph..-.hsc...sSLKslLpuG+.GhVsEhlAKWlhpstLcP.cll.tlssscppp-s.........................s.....p.....htp...t.pt.....cls.h-.............sl.-hLplLpp+FPhSL-ssVLluphuWEYhVpWsKs.pp...hcaLptulcpLctltss..tlpHGICtMlWNshLhh.hpAs.shLhpKVG+hPKD+hCppDlsMSs..stlspFLchsl-hLpph.suslscDchph........caE-uh..sEG......shPlp.LALpQ+psphsLlphHppLsoVLahlspFpl+ssKPLo.LFDuh.GppAFFtDlsp..hhs.sssD.slhp.RppFLp+VVoushch......hcps.pplh....ccltahsphscLAppWplsps.l+++.VsELYuaGhDt.Ac-lLhsls-cEhLup.LL.lAGpRLs..Lhsp..poppsh.h...lAslsspLhsaLcshp................sphcs.........splslssls+Llp+lhcpLsc	..................................................................................................h..hhplhl.hWhph....t.h..........htphtthl.hlspht..s...p......ht.pt.....l....S.WWpph.Rt.hhhpSpp.htu...Ll...sAhls...+tsuhph...............................pph.tc.tp............................p.......ppWEtlS...h-.....p.WtllltpLEDhhlLpslLtp........................hs.......p..hsp...hSl+pllpuG+.G....hls-.luKWlhppshsP.phL..p.h..ppp.-..p.........................................................p..................t.t..t......................phlt.hhhppFPhS..Lp.slLhuphsWEahspWsKc.pp.................hphh.tulphL.pt..l.ss...tlppGl...........sh........hhWssalhthhpus.shLhpKV..G+.PKD.....+hCppDlGhu-..tthspFLt.ChphLphh...hpusht..-chph............hphEchh.....s-..G.......................s.slspLA...l...pQp.....h.hsLlphH..LsslLahhhpF..pl+..sKPLs.LFDuh..uppAhFp-..l..ssh...hh..s..sphD.sh.p.Rp.pFLh+llsu...shph....................tth..................tt..a...thshpLAp.hp.lst-.l+c+.VsELYphGhDt.ucphlhplp-p-hLuspL.L.hl.sGpRLs...Lhpp..psppshth...luplsspLhsaLcshp..................htp.............thsl..htpLltphh.hLs...................................	0	31	37	66
+14508	PF14657	Integrase_AP2		AP2-like DNA-binding integrase domain	Bateman A	agb	Jackhmmer:C9L423	Domain	This family includes AP2-like domains found in a variety of phage integrase proteins.  Presumably these domains are DNA-binding.	22.10	22.10	22.10	22.20	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.78	0.72	-8.27	0.72	-4.18	212	1784	2012-10-03 08:51:45	2012-02-28 14:47:41	1	10	978	0	198	1338	40	45.30	27	12.51	NEW	pWhhph...thpshsGK++pppK.pGF+TK+EApphtpc....hhtp.....hp.....psht	.............ahhph...thcs.sGKc+ppp+.p....GFc.TK+EAptthtc....h.tp....hp.p...t.............	0	77	133	168
+14509	PF14658	EF-hand_9	efhand_7;	EF-hand domain	Coggill P	pcc	Jackhmmer:Q8N6L0	Domain	\N	37.00	37.00	37.00	37.00	36.90	36.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.14	0.72	-4.06	8	82	2012-10-02 16:17:27	2012-02-28 15:26:37	1	13	55	0	37	112	0	65.20	37	17.67	NEW	-shFcsCDsp+sGcVslS+llsYL+tsTup..sPp-s..cLpsLsp.LDPsGc..csslsLDTFpsVMRcWI	.................sFphhDsp+TGhlsltclhshLcusst...sPp-u..cLQsLhsplDPpup...uplshDsFhslMpphh..........	0	9	10	18
+14510	PF14659	Phage_int_SAM_3		Phage integrase, N-terminal SAM-like domain	Bateman A	agb	Jackhmmer:C9L423	Domain	This domain is found in a variety of phage integrase proteins.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.01	0.72	-8.77	0.72	-3.70	221	5045	2012-10-02 14:21:04	2012-02-28 17:25:28	1	28	2378	11	835	4073	332	57.40	19	15.31	NEW	oFpchh.cha..hcp.hc..tpl+.tsThtspcphlcp+IlPhF..GphclscIs..stplpc.ahNchh	..........................Thpchh.cpW.....hc..p..hp.....p.......p.......l.....c...........s........T.hpphpp.hlc..pal.h..P..h..h....G.ph..p..l.scIs..stplpp.hhpph.h...................	0	320	580	723
+14511	PF14660	DUF4458		Domain of unknown function (DUF4458)	Godzik A	adam	Jackhammer:Q8ABA0 	Domain	this domain is found in tandem repeats on the N-terminus of secreted LRR proteins from human associated Bacteroidetes domain boundaries are based on the JCSG solved 3D structure of JCSG target SP16667A (BT_0210)	22.40	22.40	24.10	29.30	20.40	20.60	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.50	0.72	-4.06	25	61	2012-02-29 08:06:47	2012-02-29 08:06:47	1	11	24	3	2	57	0	115.00	32	26.05	NEW	GhVpFKLhKsh.......pt..pts.soRA............s..sc..h.h..hu-hpKlc.lslpp..stTphspTl.....t.Lpsh.s................ps...u-.....................hGhco.....-pL.pLhAGsYplsuYphY......c+pc...pp...lhs.upss.pspsFsVhsssls	...............GhVpFKLhKsh........t......soRA............h..sch.h..hS-hpplc.lslpp..shTphspTl....t.lcshhs................Es..s-.....................auhpo.....-pl.pLhAGoYplhuYhhY.....Dchs.....ps...lht..upss.pspsFsVhsssl...	0	2	2	2
+14512	PF14661	HAUS6_N		HAUS augmin-like complex subunit 6 N-terminus	Eberhardt R	re3	Jackhmmer:Q7Z4H7	Family	This family includes the N-terminus of HAUS augmin-like complex subunit 6. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].	26.30	26.30	26.60	30.90	23.90	26.20	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.66	0.70	-5.02	27	214	2012-02-29 10:59:24	2012-02-29 10:59:24	1	4	158	0	141	215	1	211.80	21	32.99	NEW	hlapsLphLuhch.sst........shpthhshshF.KsNhpAh.hlhaaLFphhDssch+.c+Ft.hWP.hDp..tpcssFRssshchLpc..Lpcpt.tLsphspl+sshlspssG.+FhchLhphusaVlpchl+p.....h..pssssshths.spphtsss..t.hhshhtthcsphhphhpcpsth.t.apchsphlppphcslsucptt.ppth.......thpsppcpttcth.p...tt.......h.t.hpphpphWsph	.......................hhh.l.hLthc...............s.p...t.s...ht+...phpshphshaaLhph....h..D.st....tp..p...........thp.....haP.h-t..hpshphRtthhphLpc..lpcps..sLs.........p.sp..l+tohlhpssG.+FhclLhphuphVLpchlpp........h...........p...........s.ssh............p........hs.ttphtspp..t.hhshhhht..+.pphhp.hhpcpsth....t.apchs...phlpt....phcplttcp.thhppp..................p..pp.tp.......................................................................................................................................................	0	34	66	108
+14513	PF14662	CCDC155		Coiled-coil region of CCDC155	Coggill P	pcc	Jackhmmer:Q8N6L0	Domain	This is a small family of eukaryotic proteins of unknown function.ThiS is the central coiled-coil region.	30.90	30.90	31.50	32.00	30.40	29.50	hmmbuild  -o /dev/null HMM SEED	193	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.73	0.71	-11.38	0.71	-4.70	15	48	2012-02-29 12:47:12	2012-02-29 12:47:12	1	8	33	0	25	66	0	163.10	59	29.74	NEW	PATADLLSSLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEIpALRKQLRSTQQALQhAKAlDEELEDLKTLAKSLEEQNRSLLAQARQTEKEQQHLVAEMETLQEENGKLLAERDGVKRRSEELATEKDuLKRQLaECE+LICQRDAlLSERTRHAESLAcTLEEYRoTTQELRLEIS+LEEQLSQTpE	.....ATADLLSoLEDLELSN+RLsGENAKLQRSlETAEEuSARLGEEIhuLR+QL+..ST....Q....QALQhAKAlDEELEDLKTLA+SLEEQNRuLhAQARpsEKEQQHLVAEhETLQEENGKLLAERDGVK+RSpELAs..EK-sLK+QLhEsEcLICQR-slLSERT++sEuLspTlEEYRssTQELRhEIS+LEEQLSQo.p.........	0	2	4	9
+14514	PF14663	RasGEF_N_2		Rapamycin-insensitive companion of mTOR RasGEF_N domain	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.	27.00	27.00	27.90	27.40	26.40	26.10	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.29	0.71	-10.35	0.71	-4.14	35	251	2012-10-02 12:00:54	2012-02-29 13:10:47	1	25	215	0	179	269	0	112.50	36	8.19	NEW	phssa.ppWulcLLl...sQLhDsss....pVsthA.lplLcEsCppp..ssLEhllph.+.PsLspLG-hGt.Llh.+FLSpspG.a.phLsp.hsalppEh-pWh.pptNpcYVtllEsslppuhssptcs	..............s....hppWuIcLLV....sQLaD.sh....pVsptA.lclL-EACpp+..s.Lchl..lp......h........+.P........s.L.........s....H.................L..G..-..h.....G.t...........LLl.....RF.LShstG.a.p..Y.........Lsp.h....salspEh-cWh..pthNppYVsllEtpLscuhsp..........................	0	57	94	147
+14515	PF14664	RICTOR_N		Rapamycin-insensitive companion of mTOR, N-term	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.	27.00	27.00	35.40	31.00	26.60	26.10	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-12.00	0.70	-5.87	30	301	2012-02-29 14:25:56	2012-02-29 14:25:56	1	28	234	0	209	292	2	316.30	29	26.27	NEW	lp+uNsLVpLh+cpPpl+h-lshuhhs.clps...hLLscs.+-VsAAuYRhsRYhlsDtpslptlppLphDhlllhSLs+-p+s.plEREQALKhlRsh..l-l.tulpch..opulVRsllulA-c....p-DRL+shsLpTLsElhlhsPpLlhpsGGlpsLtcsLh-.usap..huEolhsslLaLLDsPpTRpalpssh-LcslhusFTD..............pscpt...t+lpsSshuIushL+oWsGlhhLupssh.psL+SLlssLplPpsp.lRcsll-Lla-lLRI+sPsWossFhsup+hsshup..h...hplp.....spspp.h...s.....t.tt.slhspahALlLhshlcuGL...lpuLlpllpssp..........ttLspKusl......LLuElL+LAsplLP	..................................................tphNphspLhpp.hs..+.c...hsh..h.c..l.h........hlLscs..ppVhAAuhRhhRYhlts....p...lphlhplp..h-hhlhhslsh......p...........p.....p...............s..phERp.............QAL+hlRt..h..lsl.............s........sp..............h...............spulspsllulupp............................pcD...c..hhphslthlsElhltsPpllhhsGGh.pslhcs.lh-...sphs.....hs-s..lhsshLalLspPpoRpalcss..h-.L-h..lhusao-h...........................hpppp.........+hpssthslhshh+oWsGll...........hst..ss...ps...lp.....u.....L.ls..............sL...ph......P.p...p......hRchll.-lla-lhp........l.......s.....s.....htpphh.u.h.h.ss.sp...h....php.........tt..t.h....t.............................tp.slhppahuLlL.hhlcsGL...............lpsLhplhpsp.s..........................lph+uol......Lls-lLphupphLP.............................................	0	76	116	174
+14516	PF14665	RICTOR_phospho		Rapamycin-insensitive companion of mTOR, phosphorylation-site	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient- and growth-factor signalling. This short region is the phoshorylation site.  Rictor does interact with 14-3-3 in a Thr1135-dependent manner. Rictor can be inhibited by short-term rapamycin treatment showing that Thr1135 is an mTORC1-regulated site.	27.00	27.00	38.40	37.20	25.90	18.10	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.63	0.71	-3.98	4	57	2012-02-29 14:26:48	2012-02-29 14:26:48	1	8	36	0	29	52	0	105.60	69	6.89	NEW	PFshhuSS+LV+NRhLNSLoLPsKKtRSoSDPKG....uKL.os-ohsuhRRsRTlTEPSl.s.spu-sFsPl.p....P+p.TlsLETSFsGhKsl--ssSTsSIGEN-lKhs+s.u	....................sFPFFASSKLVKNRILNSLTLPNKKH..RSSSDPKG....GKL.SSEsKoSNRRIRTLTEP.Sl...DFNHSDDFTPlS........ssQKTLpLETSFVGNKHlEDTGSTPSIGENDLKFsKs.hG............................................................................	0	1	4	12
+14517	PF14666	RICTOR_M		Rapamycin-insensitive companion of mTOR, middle domain	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.	27.00	27.00	30.00	27.20	26.60	25.20	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.64	0.70	-11.40	0.70	-5.34	51	266	2012-02-29 14:49:26	2012-02-29 14:49:26	1	27	232	0	188	271	0	212.50	34	15.33	NEW	hDDtpF+phlt-.opVLssK-apcWNWsllhpllcGPLhNsKRl-Esh..+ssKF....l+RLluFYR...Ph+hRFosl.hssc....s.......p+YlplGCtLhcsLLso.sEGh+hLt.cs..+llpQlucsLspl..........hsGhsstp.slFSpp+LpsTlstGYFthl.GsLSsstpGl..plLE+aphFshlhplhph.........p.s+..ssllpl.llssL......DYsh.supsRhlLsKALssusc.plRlaATchLthhlps	...............................................p-tthpphlh-.opV..Lpp.p.phhcWsWslIhpllcuP....h.hN.+.phc-t....phs+Fh+RLlsFY+......P.phpaupl.hstp.....s............ppaspsGCthhchLLpo..Eu.thhh...s.........cllpplsphLsps..................hoG.hps.p.lhspppltsTLsttYFhhl.GsL.SspspGl..phL-+hp........h........Fphhhplhph............................p..sc...scLlpL.llusL......DYoh..-u.h.s.RllLoKsLTsuoc.shRlaATchL+hhl.....................	0	62	101	155
+14518	PF14667	Polysacc_synt_C		Polysaccharide biosynthesis C-terminal domain	Bateman A	agb	Jackhmmer:C9L817	Family	This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.98	0.71	-4.40	347	5970	2012-10-02 21:24:20	2012-02-29 15:39:12	1	27	2511	0	1351	15273	3365	133.80	17	27.14	NEW	hLtlhuhshlhh.ulh.t.h.h.s....s.l.Lp.uhs+tphshhsh...hluhllpll.lshhL....l.........hG...h.........hGAuluTsluhh.l.s.shlt.h.hhlp+..h...h.p.hp....h.....h.t.p.hh...hth....h.hsuhlMslsl....hh.hthhh.....................t......sh...l...th....llsls...lGs...hl...Yhhhlhhh....ph	.......................................................h.hhshs.hlhh..u...lh.t...h...h.s....s...h..Lp.uh....s...c.p.+h.s...hh.s.h.....hh....u.s.l...l.p.ll..l...s....hhL........l............................h..a..G......h...........................hG.Aulu..T.h.lu....h....h....l....s....h...h....l.t.....h.....h...h....l..........p..........+..........h..............h.....t.....hp..........h......h.....h............h..............h....h..h...................h...h...h....s...h........h...h..h...h...h..h.............hh...h.......h.h...............................................................h.........h.....h........h.h.hhh....h.uh......hh....ahhhhhh...h.....................................................................................................................	0	455	917	1153
+14519	PF14668	RICTOR_V		Rapamycin-insensitive companion of mTOR, domain 5	Coggill P	pcc	Pfam-B_389 (release 26.0)	Domain	Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.	27.00	27.00	27.00	27.10	26.80	26.90	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-8.91	0.72	-4.05	32	251	2012-02-29 15:53:02	2012-02-29 15:53:02	1	30	216	0	185	260	1	73.00	41	5.33	NEW	lhcLKuuLWAlGal.GoophGlshLp...ptslltpllplAppsplhSlRGTsFasLuLIupTppGsclLpchGWpS	............hclKusLWAlGsl.GS.sphGhshLp..........pp..slltpIlclAcpspVhSlRGTsFaVLGLIu+TppGt-lLpchGW-.....	0	65	101	153
+14520	PF14669	Asp_Glu_race_2		Putative aspartate racemase	Coggill P	pcc	Pfam-B_34791 (release 26.0)	Family	This is a small family of vertebrate putative aspartate racemases. The family lies on TOPAZ 1 proteins.	27.00	27.00	28.00	27.50	26.80	26.50	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.67	0.70	-11.47	0.70	-5.04	3	28	2012-10-03 04:39:14	2012-02-29 18:32:59	1	2	25	0	16	34	0	222.80	63	15.17	NEW	EAGhVhssEas-hl.hhLcphpssppElssslssKS...RupAosP+puaLs-LApsVVEVELCKcpEDWs+LGslFhSVCpGsccsu-LpRFCuCVAhALLcEsKD.K.uVPFstFAETVCQ-sppDElsKTaLGRIGVSLMapYHRTppWoKGRKVL-VLScLKlEFToLKGLFGsEcGASRCQLVTlAAElFIpSGSIEGALNsLR.ENEWFlSSSoWPCEpADVpsR+RVLstL	...................................................................EAGMlLDsEHFNYIVKLLYQlQASKQEIoAVLEhKS...RLphRQFKK..NWps...DLcSALsclEHCKEKGDWTKLGsLYlNlKMuCEKF.ADhQpFCACIAEsLTK-h.K-ERPslPFCEFAETVsKDPQNSc....lDK.s.lLGR.IGISAMYFYHKLLQWSKGRKVLDKLYELKIHFTSLKGLhGPEKLAsRCQIVNlAAEIFLKSGSLDGAIWVLR..ESEWIIsTPLWPCDRhDVLNRHNLLCTI..................................................	0	2	3	5
+14521	PF14670	FXa_inhibition		Coagulation Factor Xa inhibitory site	Coggill P	pcc	Jackhmmer CATH:3kl6_B_0	Domain	This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].	33.40	33.40	33.40	33.40	33.30	33.30	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.59	0.72	-3.83	204	5651	2012-10-03 09:47:55	2012-03-01 14:05:28	1	1176	167	166	3003	5435	0	36.70	41	5.65	NEW	Cphs..N..G..G...C.s....c..h..C.h..s.s.......s.s...........s..h.p....C.sCs..p..G.a.p.L.s........s.D..sp...o.C	..............Ct.s..N...G...G....Cp...+.h.Ch.ss.......s.u.................u..a.p...CsC...s..G.a.p.L.t......s.D..t+o.C..............	0	870	1089	1827
+14522	PF14671	DSPn		Dual specificity protein phosphatase, N-terminal half	Coggill P	pcc	Jackhmeer:CATH:1ohe_A_01	Domain	The active core of the dual specificity protein phosphatase is made up of two globular domains both with the DSP-like fold. This family represents the N-terminal half of the core. These domains are arranged in tandem, and are associated via an extensive interface to form a single globular whole. The conserved PTP signature motif (Cys-[X]5-Arg) that defines the catalytic centre of all PTP-family members is located within the C-terminal domain, family DSPc, Pfam:PF00782. Although the centre of the catalytic site is formed from DSPc, two loops from the N-terminal domain, DSPn, also contribute to the catalytic site, facilitating peptide substrate specificity [1].	28.20	28.20	28.60	28.30	27.60	28.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.67	0.71	-4.19	42	431	2012-03-01 14:48:06	2012-03-01 14:48:06	1	5	262	3	265	410	10	128.20	43	23.61	NEW	lEhIpsRLYasshpp.....pP+ss...sssaaFslDc..-LsYpsF....atDFGPLNLuhlY+astpLschLps...shppKplVaYou.hcs....c+RsNAAhLlusYhllhhshoPccAhpsl.pphp....s..sahsFRDAohusssaplolhDClpGlp+A	.....................................tphhhh.h....................pspss........shhaFslDc..pLhYpsF....atDFGPLNluhlYRassclpchLps............hshtcKtlVaYou.hDt......................+cRANAAhLlusYhVlhhshoPcpA.apsl.hpss....s..sahPFRDAuaGsssaplTlhDslpGlpKA........................	0	99	145	213
+14523	PF14672	LCE		Late cornified envelope 	Eberhardt R	re3	Jackhmmer:Q5TA76	Family	This is a family of late cornified envelope proteins that are expressed in skin [1].	24.50	24.50	27.00	24.90	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.13	0.72	-10.95	0.72	-3.50	10	255	2012-03-02 13:07:00	2012-03-02 13:07:00	1	2	22	0	94	230	0	71.30	56	80.19	NEW	sPPKCP....sPKCP...PKsss.Ch....PPsSSC.CussS..GGCsGs.............SuuGGCCLSHHR.RRSHRC.RhQSSsCC-pGu.....GQQSGGSGCCHuSGGCs	.........................sPKCP.....PKCP...P.pss......s.C.........PssS..SC..CusSS..GGC.Cu..s..................Su.GGGCCLSHHR..+Rp.+Rp..R.psSssCsp.................uG.u.S.uCstuuuGp...........	0	20	20	20
+14524	PF14673	DUF4459		Domain of unknown function (DUF4459)	Coggill P	pcc	Pfam-B_10980 (release 26.0)	Domain	This family appears only on sequences from Salmonella spp.  These sequences also all carry a YARHG domain, Pfam:PF13308.	27.00	27.00	45.80	45.70	23.20	18.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-11.00	0.71	-4.53	2	68	2012-03-02 13:31:19	2012-03-02 13:31:19	1	3	66	0	0	26	0	148.70	97	33.39	NEW	MKKCFLFIFhCLFIFSANAELKFRPEhENKKIYFQGKVTDYTLNDFhFFGDSREPFYGSENDDYTATADEWLtFYAELPDVRKWQRVVPDDFShM.GAPWCDIQFFEQENDHSVITGSEHhRCIDFLVTPKRKGLIPMGTKGTLhDYGSYLAFAPQIc+	..MKKCFLFIFVCLFIFSANAELKFRPEFENKKIYFQGKVTDYTLNDFTFFGDSREPFYGSENDDYTATADEWLGFYAELPDVRKWQRVVPDDFSTMYGAPWCDIQFFEQENDHSVITGSEHMRCIDFLVTPKRKGLIPMGTKGTLMDYGSYLAFAPQIKR.....	0	0	0	0
+14525	PF14674	FANCI_S1-cap		FANCI solenoid 1 cap	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 1 cap (S1-cap) domain of the Fanconi anemia group I protein [1].	25.00	25.00	31.60	31.60	22.50	18.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.43	0.72	-3.91	5	57	2012-03-02 15:30:47	2012-03-02 15:30:47	1	5	31	6	20	47	0	51.90	63	4.80	NEW	MDQKILSLAAEcosD+LQEaLQsL+Es-LoslLTsQAVKGK-sGALLRAIFKG	..MDQKILSLAs-KTsD+LQEFLQTL+-DDLTsLLpNQAVKGKssGALLRAIFKG.	0	1	3	6
+14526	PF14675	FANCI_S1		FANCI solenoid 1	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 1 (S1) domain of the Fanconi anemia group I protein [1].	25.00	25.00	25.40	26.90	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.46	0.70	-11.36	0.70	-5.00	16	138	2012-03-02 15:31:51	2012-03-02 15:31:51	1	23	93	8	82	125	0	194.60	35	17.27	NEW	pstp+Rhplspsslptlcss-Lshchs.DlIuRLhhDlssassppLlcls-hCl-ul........................RtG-spshsWK-LLPplLss......Lusp.tplshsshtloGsEY+cpllssLssh+WsspIlsslssMFRDlsLSpEEhphVlsKlsstlpc.ls..ElPPLsaQLhplC.psuupll..L.uLp+YFpcpahc+h.sptsopoo....Dl-sI.......................shSscELR-sEtTlLaHls.ssph	.......................................................................t...+Rhtlhp.hlph.hp..ssclp..c.st-llshLhh-htphPs...Lsplsp.hl.ssl...............................+.p.ushhssp.....h-LlPhhLos...........Lssp.pplsh.....s...t....st..lsG........pEhKcpllsslCo.scWst....ph.llplssMF+Dls..Lo.s-Elp.hVlpKllphhpc.lsLQElPPLVYQLLlLuoK.G.s+.+tl..LpGlltaFsphppp....ptp...ppp.s...sp.h.....-l...l.......................s.hst..tELRclEGTlllHlsaAlc.................................	0	29	38	60
+14527	PF14676	FANCI_S2		FANCI solenoid 2	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 2 (S2) domain of the Fanconi anemia group I protein [1].	28.50	28.50	28.90	29.60	27.90	28.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.60	0.71	-4.33	25	145	2012-03-02 15:32:28	2012-03-02 15:32:28	1	27	102	8	94	147	1	152.00	36	12.64	NEW	tllpulVphuFhLL-..........uttssptpsht.hpt.....................LGlplLhphF+hHphsRscIl-plhsRllsppsp.sspal...................cLLuhlspstshhllEpsuplp.....-hh-al.salssssuptllsAlhPLlKlS.tsl+DtlILVLRKAMas+-hssRhsAVsGalp	.....................................hVspGLVpLuFhLh-...................................uhssp+h.s.stshps..shtp...........................................LGtslLlchF+hHchhR.......p..cIl-plhsRllopsss....s.p.a.l....................................-LLupllhtsPhhl.psss+lp.....-hhDal.saLPhps..sptLlpAl.PLlKlS..hshRDuLILVLRKAMFup..ph...s..sRpsAVsGFl.h....................................................	0	34	44	72
+14528	PF14677	FANCI_S3		FANCI solenoid 3	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 3 (S3) domain of the Fanconi anemia group I protein [1].	25.00	25.00	25.80	25.90	24.80	21.80	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.21	0.70	-4.96	13	99	2012-03-02 15:33:04	2012-03-02 15:33:04	1	14	71	8	57	106	0	205.40	38	17.27	NEW	lLohphlScLLshLFcDssp.u+pEsLulLRSss-ah.RYuVsVslQKlQQLc-p..sDss-upssc+hFcpLCDIT+VLhhRhsshsssl.c-sG.....polSlLslEshhclhsslpppYss+hspFLpslDssssstpc...........slTppsthhI+pFQ+slhs.hs.us-DsFsuKpslhLlslLohLucpLsPuSsphs.QhhsWslplC+cpsl-DsuhsKGLl.sLLF	............................................lhshthlspLLphLacDsst.uppEslslLRSsp-Fh.+YslslslpKlQplcpp.....sshsptppsc+hFp..pLs-IT+VLhW.R..Y..TslPosV.E-sG++.KtcolSLLCLEG..Lpclhssl.pphYps+lppFLpul.....Dsssppspc.t.......hslsppsth.I+pF...Q..Rsl....h......s.LS...upc--F.sSK-sl.lLlslLosLo+hL-P..uSsphs.p....hhoWs.+lC+-ssh....-Dst..hsKuLh.sLLF.............................	0	15	19	37
+14529	PF14678	FANCI_S4		FANCI solenoid 4	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the solenoid 4 (S4) domain of the Fanconi anemia group I protein [1].	25.00	25.00	66.30	32.60	24.40	23.20	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.40	0.70	-5.28	19	132	2012-03-02 15:33:39	2012-03-02 15:33:39	1	22	97	8	84	138	0	235.70	35	20.15	NEW	sshLpclupsltspLGslc..p-sps.....-pps..pauhlshcTAu.olhtlllup.lp+lL--V-Whls+hps.httsphs........psspsthtsshcshE+ulhtQLspllpslpcLspsslPsGush-slhKtLt+hYshLosLsKaYlphssspts...thsscFEcL.l+h.............sGopLsspsYshIoY......lpttpp-p.spppp.....p........tttspsthAKlLRET+.IPslIauIEpaEKalIpLSKKoKl..NLhpahKhSTsRDF+IpuspLcsAl	.........................................................h..hhpclupclpt.lGslc....pD.pl.........-pss...pashlshcTus.olhhhllup.s-csL--VDWlls+lKs.hstpphs........ptspsphph....tpshE+ulhhQLspllphhpcLlpsulPs.G...o.ssDsLLKtLs+hYshLosLsKaalpsppspts....hstph-+L.V+l.............oGpp..LTs.hYsFIoY.......................lpp...p...p.....p...pp...t..t....ttpt........................tt.ststhA...+lLR....ETK.IPsLIFsIEpYEKaLIpLSK......KoKl...............NLhpahKhSTuRDF+Ipss.Lp.sl..................	0	33	41	61
+14530	PF14679	FANCI_HD1		FANCI helical domain 1	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the helical domain 1 (HD1) of the Fanconi anemia group I protein [1].	25.00	25.00	25.20	29.20	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.20	0.72	-9.65	0.72	-4.25	19	101	2012-03-02 15:34:20	2012-03-02 15:34:20	1	17	66	8	57	95	0	85.00	44	7.08	NEW	pLGREll+alKsst....tpsLsPFslulLLSVuplpRFc-plh-hL+oslh+sh+D.phppsu+WLpchl.ppssltshll-slpso	..........-LGREllKtLKssp..t.ssssLsPFSlALLLSVsRIp.RFpEQVhDlLKsullKuaKDhQlhpuSKaLpsLlPpc..s..sVushILEVV+NS.............	1	17	23	38
+14531	PF14680	FANCI_HD2		FANCI helical domain 2	Eberhardt R	re3	Jackhmmer:Q9NVI1	Family	This is the helical domain 2 (HD2) of the Fanconi anemia group I protein [1].	25.00	25.00	35.80	30.60	23.90	22.70	hmmbuild  -o /dev/null HMM SEED	234	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.36	0.70	-5.25	16	147	2012-03-02 15:46:03	2012-03-02 15:46:03	1	24	99	8	94	147	1	212.30	33	18.07	NEW	su.....Sp.sSp.tsshoQlplss+ophsss...sN.-sLsLEIlG.LRRCLsQQA-VRlhLY-GhY-slcpNupLusplLphLhsph+paa-s........-.DhlsPl+l-sClsupG-p...lhLpEPLu+LlpslspCLthhpps.sstss.s..............El..splLESlopRMl+s-..LEDFpL..........................Dcss-hs.pssssuhcpshhshhhhulhEsLIpaphht..sshscsph...cclLuLFcsYpKLs-hLKc	..................hs..spphSt.t..shSQ.splsspuphsss......tN..-shsLEIhs.L.RRCLsQQA-VRhhLY-GhhcllppN....s.pLusplhphLhs.p.h..+.p.a.acs..........c.DhlsPlKl.-tClh..........spusp.............l.LpEPLspLlpslppCLthhppt..shptt..........t.p...............h.pcl...........pphL..-ohspRMl+s-....LEDhpL.......................................Dcst...-hs.psos.huhcsphh.s.hlhulhElLl-aph.h.....sphscp..ph....cpll.sLF.papcLp-hhp...............................................	1	32	42	72
+14532	PF14681	UPRTase		Uracil phosphoribosyltransferase	Bateman A	agb	Jackhmmer:B0C7X6	Domain	This family includes the enzyme uracil phosphoribosyltransferase (EC:2.4.2.9). This enzyme catalyzes the first step of UMP biosynthesis.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.37	0.70	-11.12	0.70	-5.12	113	5012	2012-10-10 14:25:38	2012-03-05 13:22:09	1	28	4240	67	1505	3471	1360	199.90	43	83.73	NEW	ls.s+PhlpthhohlRspsT.ssspFcthhcclsplLshEAhs.p..Lsh.p..pt..plp.....TPl......utth....s.s....h.h....h.st......plshVsILRAG.................................uMhpulpsl.hPs.s.plt+lhl.R.-c..pT..................hp..P.........aYp+LPppl........sppp..................llllDP...hlATGuoshtAlchL.hct...sst.ppIhhlsll......u....usp....Gl......pplttpaP..c.lc.lhsuulDppL..s.-puaIlPGLGDhGDRhFGT	.........................................................................................................................sHPLlpH.KLollR..-.p........c..T..uop..c..FRc..LssElupLh.............s.....YE...............so+..D..L........h..c.......cs...pIc.............TPh..........ut.sp...sp.....p.l............t..u+..........KlslVPIL...R.A...G..l................................G.Mh-.....Gl.L.p.l...l.......P...u.......A...+.......l.......G.......h.......l..G..l..aR....D.E....-T.............................................Lc..P.s.............Y.a...t..KL...P.p.cl......scRt...................................slllDP...MLAT..G............G.Sslt.........AlchL.Kc+......Gs.....ppI+hlsLl......A....APE......Gl......cslpc...u.HP.....D....Vc....l....asAul..DccL..N..-+......G.................Y.IlP.G.....LGDAG......DRlFGT...............................................	0	468	899	1262
+14533	PF14682	SPOB_ab		Sporulation initiation phospho-transferase B, C-terminal	Coggill P	pcc	CATH:1ixm_B_02	Domain	Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain, represented by this family. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate hereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor.	27.00	27.00	29.60	28.60	25.00	24.00	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.57	0.71	-4.29	12	140	2012-03-05 14:41:45	2012-03-05 14:41:45	1	1	137	10	21	74	0	113.40	51	61.89	NEW	hPphAthlLTaNWcs+.hpLEaEVLG-l+sLpth-ppLhshspplFshhcpuls.tsENHLslolphp..-......ptlplaFDFpGhls.shptlpp.hpp.tptp.thphhphcls-cEssl	...MPLFSEWILTYNWKQQPsLLEYEVLGc..L..+N.LS+hDEpVCTWosQFFSMLQHSLDVY..VENYVCITIEsDu........-NARFFFDFRGKLT..slEELQs.WLu.spNN..cahsISYoVRDEElSl..........................	0	5	13	15
+14534	PF14683	CBM-like		Polysaccharide lyase family 4, domain III	Coggill P	pcc	CATH:1nkg_A_03]	Domain	CBM-like is domain III of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain possesses a jelly roll beta-sandwich fold structurally homologous to carbohydrate binding modules (CBMs), and it carries two sulfate ions and a hexa-coordinated calcium ion.	27.00	27.00	28.00	27.80	26.00	25.30	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-11.08	0.71	-4.61	56	304	2012-03-05 16:42:11	2012-03-05 16:42:11	1	23	130	5	211	322	1	176.50	27	28.84	NEW	sslWcIG..DtossuFhsu-...............phhR.H...sc.schtshtsLsYTVGsS.tssDashAphpchs.......sshpIpFpLsssp.hs..tshTLRlulstA.........suucspVplNs...hsus......ssu..tshthDspshp+GsapGhhclYshslPuutLhp..Gs...NTlplssss..........uo......s.h..uhhaDslcL	.....................slWcIGhsD+oustFhhs-......................................pphRta....p..c...schhP.t.t.slsYTlGpS..tpDa.aup..hsths...........................ssapIpFsLssspht...tshsLclul..AsA..................ss..u..ch..pVp......lNs...sss...............hss.......ht.pcsshsc+Ghp.Gh...ht.....hap..hslsushLhpGs...Nsl.hls.sp..............us..........t....shhaDhlcL....................................	0	52	129	181
+14535	PF14684	Tricorn_C1		Tricorn protease C1 domain	Eberhardt R	re3	CATH:1k32_A_03	Domain	This domain is the C1 core domain of tricorn protease. This is a mixed alpha-beta domain [1].	24.00	24.00	24.00	24.00	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.23	0.72	-4.10	129	801	2012-03-06 14:27:51	2012-03-06 14:27:51	1	45	538	24	226	719	107	69.70	30	8.07	NEW	ttEhpphFc-sWRhh+-p..FYss.....c.h+Gl.D..WpultccYp.hlsplsspt-hscllsEMlGELssSHshhpss	....................tEhtthF-csW+hhccp...F....ac......s..hpGl..D..WpultspYp.hlsphp...sp..p-.ht-lLsEhluELssuHstst...........................	0	99	185	216
+14536	PF14685	Tricorn_PDZ		Tricorn protease PDZ domain	Eberhardt R	re3	CATH:1k32_A_04	Domain	This domain is the PDZ domain of tricorn protease [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.81	0.72	-4.19	47	349	2012-10-02 11:12:46	2012-03-06 14:32:34	1	16	297	24	103	348	96	86.50	37	7.96	NEW	GhLGADhph.c..s..sp..acls+IlsG-shsscs+SPLstPGlplptGDhllulsGpslssstsPttLLsspuu..ptVpLolpss.su..ssRclsV	.................................GhLGA-lsts..s..ss..h+ls+lhsG-spsspttSPLstsGlslppGDlIlAlDGptlsss.......ss.htpLLpG..p.A.G..+.VpLolppsss....ttRplsl...............	0	39	75	94
+14537	PF14686	fn3_3		Polysaccharide lyase family 4, domain II	Coggill P	pcc	CATH:1nkg_A_02	Domain	FnIII-like is domain II of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain displays an immunoglobulin-like or more specifically Fibronectin-III type fold and shows highest structural similarity to the C-terminal beta-sandwich subdomain of the pro-hormone/propeptide processing enzyme carboxypeptidase gp180 from duck. It serves to assist in producing the deep pocket, with domain III, into which the substrate fits [1].	27.00	27.00	27.00	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.28	0.72	-3.87	51	306	2012-10-02 19:08:27	2012-03-06 16:19:16	1	22	139	5	207	340	67	90.20	27	15.07	NEW	pRGsVoGph....Ghs......st.s.hhVGhs.............spshQYWspAt.ssGpFslssl+sGs.YsLhsat.........u-hpst...ssslsVo.uusst.slush	.....................................tRGsVsGplh....th.................h.t.shVGht..tt........t....spshQaWsp.....sc....ssG.....p.FsIssl+sGs..YsLhsas.........su...hG-ath....psslsls.supsh..p....h..............................	0	50	125	175
+14538	PF14687	DUF4460		Domain of unknown function (DUF4460)	Eberhardt R	re3	Jackhmmer:Q8N3R3	Family	This domain family is found in eukaryotes, and is typically between 103 and 119 amino acids in length. There is a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important.	25.30	25.30	26.10	28.30	25.10	25.20	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.87	0.71	-4.32	31	156	2012-03-07 14:34:13	2012-03-07 14:34:13	1	4	113	0	111	150	0	103.70	33	20.81	NEW	hhppRphtssclpsAL+PFYhtVHPDhFsp.aPp.p+psNEcSLKhLsuaL-sLpp.t.......scstpLpFYlpcssssp..t........pa+hVplpl....s...ppD...........scphlpplLcsCsL	........hh...+thtsschtsALRPFYhtVHPDhFup.aPp...p+plNEsS.....LKtLssaL-sLpp.t.............shpstpLsFYl+pss....pst.................ta+hlphpL.....p........spc..............phl..llppCpL..............................................	0	44	61	90
+14539	PF14688	DUF4461		Domain of unknown function (DUF4461)	Eberhardt R	re3	Jackhmmer:Q8N3R3	Family	This domain family is found in eukaryotes, and is approximately 310 amino acids in length.	24.00	24.00	25.40	24.80	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	313	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.09	0.70	-11.79	0.70	-5.09	24	123	2012-03-07 14:36:20	2012-03-07 14:36:20	1	6	90	0	86	118	0	275.60	30	57.36	NEW	cpsLssWLccsttpApp+tcsstsl+cElp+L+ppLspphsLpclpasCGWsltH..hpus..LpoLp+L..sp...ppsp.....hpsL+...s+sllFu.shoGlShpGc..VMLsosDVpcsWhcllcpls.pacth..lptlshhEptlSplLtsIpls+hchh..PthpsptYtspLpplhsultca..hsttth.p.hPps.Lpshplslpo-u..ushhl....usoGphllPuosssshLlsFlspphcpApc+hpcacp.pthEcpLhspChcphpLppLsKD-ulTs-pMIsssp+LLpt...........t............hpGlpLplopYYS..VhoDGsl...CIPW-Wc	....................................................................sLpsWLcpsttpAhp.+hcpshsl+pElp+LcptLsppLtLpDlpappuWslsH..hpup....LpoLpRL..uppp.p....hhpth+...GpsllFs..stoGhoh.Gc....VMLsohDV..ppWhchhcpls..pa.sh......ptl.hhEcplStlLtuIplshhc.h..Phhph.ptYhshLpthhspl.c......hh...h.........Ppo.Lps..h.....ph.llpo-t......hs..l..........pphGpF.lPs.sCssspL..Fl..pp.hpp.Apcphp+hpp.................phhEppLhptshcchpLppL.hK.-.sul....osspMlsCsc+Llp..........t.h...............shLpGhpLplo+aYS.....VhpDGsl...CIPWsap...........................	0	31	42	66
+14540	PF14689	SPOB_a		Sensor_kinase_SpoOB-type, alpha-helical domain	Coggill P	pcc	CATH:1ixm_B_01	Domain	Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerise by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, Pfam:PF14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.56	0.72	-8.96	0.72	-4.41	56	2392	2012-03-07 16:11:40	2012-03-07 16:11:40	1	29	1272	10	403	1561	22	60.90	32	12.52	NEW	htt.th...ppllcsL.+ppRHDahN+LQlIpGhlpLs+h-+spchIcplspchppp.ucl.spl	.....................ph...tpLstlppYs-uL.RspsHEahN+LpslhGLLplppY...-...cl....h....phlpptspt.Qp.........h.t..................	0	139	263	333
+14541	PF14690	zf-ISL3		zinc-finger of transposase IS204/IS1001/IS1096/IS1165	Coggill P	pcc	IS-finder, manual	Domain	\N	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.75	0.72	-8.23	0.72	-3.93	135	4025	2012-03-07 16:36:10	2012-03-07 16:36:10	1	22	1094	0	544	2757	127	47.00	38	15.25	NEW	pshtCPpCG........pps...hhtpsp.pppph+.clshtsptshltlc.ppRapCp...p..C	...........p.sssCPcCG..........sph....t+hchp...+so+Is.hLcs.sG.hPohlhL+...KRRF+Ch...p..C..............	0	144	375	439
+14542	PF14691	Fer4_20		Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	Coggill P	pcc	CATH:1gte_A_02	Domain	Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyses the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds [1]. This domain carries two Fe4-S4 clusters.	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.44	0.72	-11.01	0.72	-4.44	327	6849	2012-10-03 08:56:43	2012-03-07 16:55:41	1	286	3369	26	1619	4929	2276	110.70	35	17.58	NEW	Rtps.F.pEVshGaotc.pAhtEApRCLp.....C....t.ss...Ch.p.....uCPlslsIPpFIctltpGs......hptAhchIppsNsL.PulCGRVCPQEp.CEus.....Clh........t.....p..s.p....PVsIGpLERaluDhthpp....sh	...................................................h...t.a..Eh.....s.h.s..t....ps...t..pus.R..C..h..p....C..........s..ss.......Cp..p............uC....P....l....pst....I...Pp...a...lcLl..t.....cuc..............h.ppAhch....lp.p.........TNsh.P.t.lsG.RVCPps..CEuu.....Csh.........s....s.p..s............sVsItslE+alsDpuhp.s.h................................................	0	581	1077	1386
+14543	PF14692	DUF4462		Domain of unknown function (DUF4462)	Eberhardt R	re3	Jackhmmer:A8MTB1	Family	This domain family is found in eukaryotes, and is approximately 30 amino acids in length.	25.00	25.00	35.40	25.90	24.20	24.40	hmmbuild  -o /dev/null HMM SEED	28	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.61	0.72	-7.06	0.72	-4.69	24	153	2012-03-08 11:34:24	2012-03-08 11:34:24	1	11	7	0	148	149	0	26.80	66	21.88	NEW	uAKSR.sWNhLPRAusl.......GIGCQEQVQLE	....sAKSRhsWNhLPRAGsl.......GIGCQEQVQLE....	0	148	148	148
+14544	PF14693	Ribosomal_TL5_C	ShortName;	Ribosomal protein TL5, C-terminal domain	Punta M	mp13	CATH:1feu_A_02	Domain	This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, Pfam:PF01386. Full length (N- and C-terminal domain) homologues of TL5 are also known as CTC proteins. TL5 or CTC are not found in Eukarya or Archaea. In some Bacteria, including E. coli, this ribosomal subunit occurs as a single domain protein (named Ribosomal subunit L25), where the only domain is homologous to TL5 N-terminal domain (hence included in family Pfam:PF01386). The function of the C-terminal domain of TLC is at present unknown.	27.00	27.00	29.80	28.70	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.63	0.72	-9.84	0.72	-3.78	195	2672	2012-03-08 13:20:59	2012-03-08 13:20:59	1	2	2591	91	749	1875	2003	88.30	28	43.06	NEW	EclplcVPlphhG..-...usGhp.t.G.Gllpp.hpplplpsh.PsslP-plpVDlssL.c.l.GsslpluDl..p..l..P...p..G..lpl.s.......s.....-...s-t......sllolssspstc	................plplcVPlphhG..c...usGlK.p.G.GllppshpplcVpsh.spslPEtl-lDlosL.c.l.G.cslpluDl..p..l..P...p..G..lpl.h...............s..c...s-.......slsslhtsp.........................	0	274	534	658
+14545	PF14694	LINES_N		Lines N-terminus	Eberhardt R	re3	Jackhmmer:Q8NG48	Family	This family represents the N-terminus of protein lines [1]. In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator [2-3].	25.00	25.00	27.70	27.70	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.26	0.70	-5.17	9	107	2012-03-08 13:57:56	2012-03-08 13:57:56	1	4	78	0	67	108	0	284.60	32	45.46	NEW	hslohsDsESa.DooplKs.slKtLts+WssLlcth.spllpp.........ssspstsslloFLcLWEslISV..KANLSlh-T+PFaupLsphlhLLssslsshla+phLsLFN........EsLCYGSTLALQ-...hLs--ssuLActll+sV+chRlL-pLPhpptsu.................................phuuupus............sshD+sLLQKMuLLVLKSlAlpl+EhR.ssSSDSSlcSpc.D..t-hthIpRSIR-VLppL-salKspLpFHP-sphuchLl+lFtDQDD.hlEAMVCoLDltsGloa.cssAsssLs.........th....LNPshoFltFL+hluaDocVLLDhLlSsETCFLLYLLRaLKalRcNWshFlpsCt	............................................................................................................................hlshh.pE.h..Dost.Ks...hlpph.p.asshhcsh.splh.s.p.............tsth.p.lhsFL.pLhE.llus....thpLpht....pp+.hahp.sth..ll.sh.s.l.shlh+phlhhhp........EsLsh..G..S..s...s..L.s.......hls.-hhtLAptllptV.shthLcplshpt..s.....................................hGsspst...st..t..t.DpslLpthsLlllKSltlphp....sso.S..ssp..........hc..s............lpp.hpclLthL.c.hlp.php.p.......p.schl....plF....-QDDphlEuhhs.Lslh.....t...lsh..ttps.h...pLs.......................th.........hNPhhhFl.hLc.huasss.lL.LDhLlSsE...TC..FL.YhlRaLKhlpts.Ws.Fhp.C................	0	21	27	46
+14546	PF14695	LINES_C		Lines C-terminus	Eberhardt R	re3	Jackhmmer:Q8NG48	Family	This family represents the C-terminus of protein lines [1]. In Drosophila this protein is involved in embryonic segmentation and may function as a transcriptional regulator [2-3].	27.00	27.00	37.70	36.80	21.40	19.80	hmmbuild  -o /dev/null HMM SEED	39	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.47	0.72	-7.76	0.72	-4.71	20	93	2012-03-08 14:10:50	2012-03-08 14:10:50	1	4	76	0	64	97	0	38.70	47	5.50	NEW	cshssLlcL+huIpRLhpKsLFPYNssPLLR..LLcpsEpL	.....cshpsLhcLphsIsRLppKsLFPYNsssLL+..LLcphEsl.....	0	17	24	42
+14547	PF14696	Glyoxalase_5		Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal 	Coggill P	pcc	CATH:1cjx_A_01	Domain	This domain is one of two barrel-shaped regions that together form the active enzyme, 4-hydroxyphenylpyruvic acid dioxygenase, EC:1.13.11.27. As can be deduced from the disposition of the various Glyoxalase families, _2, _3 and _4 in Pfam, Pfam:PF00903, Pfam:PF12681, Pfam:PF13468, Pfam:PF13669, these two regions are similar to be indicative of a gene-duplication event. At the individual sequence level slight differences in conformation have given rise to slightly different functions. In the case of UniProt:P80064, 4-hydroxyphenylpyruvic acid dioxygenase catalyses the formation of homogentisate from 4-hydroxyphenylpyruvate, and the pyruvate part of the HPPD substrate (4-hydroxyphenylpyruvate), derived from L-tyrosine, and the O2 molecule occupy the three free coordination sites of the catalytic iron atom in the C-terminal domain. In plants and photosynthetic bacteria, the tyrosine degradation pathway is crucial because homogentisate, a tyrosine degradation product, is a precursor for the biosynthesis of photosynthetic pigments, such as quinones or tocopherols [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.70	0.71	-4.24	17	1091	2012-10-02 15:00:03	2012-03-08 15:28:49	1	6	816	6	336	996	193	140.50	36	33.00	NEW	FENPhGl-GFEFVEFuuP-..s..ttLcslFctMGFTtVA+HRSKDVsLYRQGsINFIlNtEPcS.AthFup-HGPuACuMAFRV+D.AppAYccAl-hGApPlpht.sGsMELplPAIKGIGGuhlYLlDRas-us..........SIYDlDFE	................................................hthsGhEFlE.F.s..s..ss...s...pp..Lt..t.la.p.p.h.GFstl......A......+......H......Ro...K..s..l..h..La..RQG....s..Ishll.......N......u................-..P...c..S....h..AppF....s...p..pHGPulCuhAhRVcD.AppAap+AlphGA....t....s....h....p....s....t....s....u....s.t....E....Ls......l....P.A.I.p.G.l...GsSllYhVDR..h..tt..t..........slY-.DF..........................................................	0	72	164	254
+14548	PF14697	Fer4_21		4Fe-4S dicluster domain	Coggill P	pcc	manual	Domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases.  Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.	35.00	35.00	35.00	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.04	0.72	-4.11	63	3437	2012-10-03 08:56:43	2012-03-08 16:17:41	1	136	2521	25	833	2684	375	57.90	41	22.32	NEW	AhIcp-tCIsCs+CahAC.DsuapAI.......t..h...s..sc..p.....t..h.......s......l.l...p.-.-.CsGCsLCsslCPl...-CIsM	...........................hIsp-pCI......G...Cs.p..Chp.A.CP.......l.cAI..........................h.....s...s.c...p........h...p.................................s......l.h....s..-..pC.s.G..CpLCsssCP..s..cCIp.............	0	245	478	670
+14549	PF14698	ASL_C2		Argininosuccinate lyase C-terminal	Eberhardt R	re3	CATH:1k7w_A_03	Domain	This domain is found at the C-terminus of argininosuccinate lyase [1-2].	24.00	24.00	24.40	24.10	23.50	23.40	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.54	0.72	-9.29	0.72	-3.90	617	4020	2012-03-09 08:50:06	2012-03-09 08:50:06	1	16	3666	53	1083	3103	1579	70.50	40	15.17	NEW	assATDLADYLV+.+.GlPFR-AHclsGphVt......hu.pcs..hs.Lp-LoLc-hpp....h.....s......shl.......s.p....D...lap.sLsl-suVsp	...........ausAT-LADYLVpK.GlPFR-AHclVGcsVh..............huhppG....hs...Lp....-...LsLp-hpp........h.........s......shl...............s..p....D........lap.lLshcsslp.....................................................	0	329	677	908
+14550	PF14699	hGDE_N		N-terminal domain from the human glycogen debranching enzyme	Godzik A	adam	Jcakhammer:GDE_HUMAN	Family	this domain is found on the very N-terminal of eukaryotic variant\	     of the glycogen debranching enzyme (GDE), where it is immediately  followe by the aldolase-like domain. The eukaryotic GDE performs  two functions: 4-α-D-glucanotransferase (EC 2.4.1.25) and  Amylo-α-1,6-glucosidase (EC 3.2.1.33), performed by the,  respectively N- and C- terminal halfs of eukaryotic GDE enzyme hGDE_N domain is involved in the glucosyltransferase activity,  probably\	    as a substrate binding module (by analogy to other  glucosyltransferases)	22.10	22.10	22.70	26.40	21.30	20.30	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-9.97	0.72	-4.14	68	237	2012-03-09 12:36:43	2012-03-09 12:36:43	1	12	206	0	168	232	0	94.70	30	6.56	NEW	pLRFt..G.u.S.lsRcGslasNhPtsup..pFcRsp..apphclp.............s.......s...........hspshplclslppsGuFsaYhsY.......................csp........cosphYhsVsPtLplsu	.........................LcFt..Gs.S.lu+psslaoNh.....P.......pGp..pFpRsc..F+phphp................s............s.................hspchhhcl.s.lppuGuFpaYhsa..........................sspt......tcosshYlsVsPtLpls.s............	0	45	81	132
+14551	PF14700	RPOL_N		DNA-directed RNA polymerase N-terminal	Eberhardt R	re3	CATH:1msw_D_01	Domain	This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme [1]. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex [2].	25.00	25.00	27.60	25.90	24.40	23.80	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.21	0.70	-12.02	0.70	-5.17	126	554	2012-03-09 13:37:42	2012-03-09 13:37:42	1	14	381	20	280	574	278	279.60	19	28.13	NEW	p+QhpLEpcuh..ctAhc+a+cthc....chpcp.uh..shsh........lpslhhpWapsLtstlpc-hc...............h..........................................ptppptpstassaLp....................hlss-chAsITlppllshhs.sts..httsh...................plsphshslGculEpEhchpphhcp........t.p.........ppppttpp.................................+php............phlcppphpt...........htthhttt................................................Wspss...ps+lGuhLlphLhc.s........uhlpsst.......tssts..........t..PAFhHthph.........sp+h.Ghlchsstlhch.....lscpstt..h......s.ah......P....MllsPcPWs..uhspGGYh.hht...o.lhRs+ss.........tppphhhpshpp.splp.......pVacuLssLGp	...................................................................................................................................................tQhthE..psh..ttuhtchpp..p.......ph.ph..t........h......hpthhhpWht.lhttlppphp........h..................................................................................tttttp..hhsalp....................hlsscp.h...u.hlshhphhthhh.stt...................................................phhphhhtlGptlpp-hph.pphhpt........................t.p.h........t...ppt...t............................................pthh.....phhptt.t.tt....................................................................................................W.s.t...th...phclGshLlphLlp.s.........shlphpt.........tt..s...............................................t..sshhp.hph.t.............spph..shlchps.lhph......l....pppsh...............s.hh.......PMlsPPpPWs..u.hppGG..Yl..ht.........stlhRspt...........ppp.hhtthtp...sp.hp.......tlhcuLshLup..................................................	0	86	164	238
+14552	PF14701	hDGE_amylase		glucanotransferase domain of human glycogen debranching enzyme	Godzik A	adam	Jackhammer:GDE_HUMAN	Domain	this is a glucanotransferase catalytic domain of the eukaryotic  variant of the glycogen debranching enzyme (GDE).\	\	The eukaryotic GDEs performs two functions: 4-α-D-glucanotransferase  (EC 2.4.1.25) and Amylo-α-1,6-glucosidase (EC 3.2.1.33),\	performed by the, respectively N- and C- terminal halfs of  eukaryotic GDE enzymes. hDGE_amylase domain is a catalytic domain responsible for the glucanotransferase function. It belongs to the  alpha-amylase clan and is predicted to have a structure of a 8  stranded alpha/beta barrel (TIM barreal) where strands are  interuppted by long loops and additional mini-domains. In most other amylases, the catalytic domain is followed by a beta- barrel substrate binding domain, but presence of such domain cannot  be verified in the human (and other eukaryotic) GDE enzymes	21.40	21.40	21.40	21.40	21.30	21.30	hmmbuild  -o /dev/null HMM SEED	423	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.38	0.70	-5.57	65	321	2012-10-03 05:44:19	2012-03-11 07:14:19	1	22	258	0	228	1087	85	363.10	35	27.98	NEW	c.LPLsulsl.oVlSKahGs.h..s.-W-c+lpsluc+GYNMlHFTPLQpRGtSNSPYSIaDQLpaDsshFss.......s..p........pDVpphlc...chcc-..aulLSlTDVVaNHTAsNSpWLpEHPEuGYNhpTuPHLcsAhELDssLlcaScpL.....pph.G..LPsplco.p-DLtplhssl+pcVlspl+LWEaYslDVccsscphhctap...........ssp.........s.shs...p...s............................s.hpp.pt.....ph...............lpc..t............hhp....RaupclDsp....h....sh....sl.hsph.....tps....ssc......h...cpstp..phpclL-clNlshYcEaDsDlppIlpplhsRI+YhRl--cGPKLGs.loccsPLlEsYFT.+..h.p.pt.p.............ptpphsLANNGWlWs.usPLhDFAu.sp...S+uYLRREVIVWGDCVKLRYGspP-DsPaLWc+MscYochhA+hFsGFRIDNCHSTPLHVAEalLDtAR+VpPsL	...............................................................t..lPLsslsl.ohluKhhG...h....s.cWc....p....cL.phhpc...pGY...NMl...HF...T...P.l......Q.........p...h......G......t......S......p.........S..sYSlhDQLphssphh.s............................sp...........p-l.tphlp...ch...cpc.....aslLsloDlVhNHT.AsN...SpWLp...-...HPEs..uYNhhsu....PaLp....sAh.LDptLhphuppl....................pph...GlP.s....l.cs..p.cl.........tlhphltpplhsplcLWE..aa.l-Vppthp.thhp.hp...ptp.............p.....p...........................................................s..p..hph............lpp.................hpRhsppls.p.h....sh....thh..h........ttt.......st......ppstphhpphlctlN..hhpphp.t.chp...............thlpplhsplpY.RlsspGP+lG..lopc.p.P...LhptY...FTh..tp..........................pttphhhApNGWlhs.sssLhshAt.st...SpsYLRRElIsWGDsVKLRYG.ppP-DsPaLWpaMpcYschhAphFpGhRlDNCHSTPlHVuEahLDtARclpPsL................................................................................................	0	81	124	184
+14553	PF14702	hGDE_central		central domain of human glycogen debranching enzyme	Godzik A	adam	Jackhammer:GDE_HUMAN	Domain	this is a central domain of the eukaryotic variant      of the glycogen debranching enzyme (GDE). The eukaryotic GDE performs   two functions: 4-α-D-glucanotransferase (EC 2.4.1.25) and  Amylo-α-1,6-glucosidase (EC 3.2.1.33), performed by the,  respectively N- and C- terminal halfs of eukaryotic GDE enzyme The hGDE_central domain follows the glucanotransferas domain and  precedes the glucosidase (GDE_N) domain. It is very likely that the current definition contains two or more domains, by analogy  with baterial GDEs, this domain should be involved in substrate  binding either for the N-terminal glucanotransferase  and/or the the C-terminal glucosidase (or both) 	19.80	19.80	20.70	20.40	18.80	17.30	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.78	0.70	-5.21	58	283	2012-03-11 08:10:09	2012-03-11 08:10:09	1	19	228	0	207	282	0	236.10	34	16.88	NEW	GIuslKphLNcLHpphupcua-.....EsalHp.-scaIslpRhsPcTp+GhhLlA+TAFssssss......tslsP.lpLsG.opschlhuhpL......pttssp..........c............hhpDcphLpGlPsplh-lps.............th..pt.tppstlhh..psFsPGSIhlFcTplssss....t.Lcp.l..................................hps..ustcAhspLsLhDLNhlLYRC-sEE+D..ss.Gps...GsYsIPs.aGpLVYsGLQGWhSlL.cpIhtpNDLGHPLCspLRpG..pWAlDYllsRLp	.................GIhssKphLNplHpphutcGas............psalcp..-sphl.sVpRhpPpo+puhhllA+TA.Ftsspss......ttlss.hpl..sG.phtchlhphpl.........t.p.ssp..........t........................hhpDpphlpGlPsh.hhplpt.h..........hth..ps.tp.sp.h.hpphsPGSlhlFcsplss...ts......s.Lpp.l....................................hpp..shtph.hsp...LsLh-.LNhlL...YRC-sEEp-.s..ttsGsYsIPs...aGtLsYsGLQ..........GhhSl.L.pcIh....p.NDLG..HPlCs.NLRsG..pWhlDYlssRL...................................	1	73	112	168
+14554	PF14703	DUF4463		Domain of unknown function (DUF4463)	Godzik A	adam	Jackhammer:Q9P1W3	Domain	This is a cytosolic (predicted) domain present in integral membrane  proteins, such as TM63C_HUMAN TRANSMEMBRANE PROTEIN 63C. This domain usually preceeds a DUF221 (PF02714)domain and follows  a RSN1_TM (PF13967) Fold recognition programs consistenly and with high significance  predict this domain to be distantly homologous to RNA binding  proteins from the RRM clan.	22.80	22.80	22.80	22.80	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.76	0.72	-3.46	198	880	2012-03-11 09:12:07	2012-03-11 09:12:07	1	21	225	0	638	834	0	88.20	22	10.30	NEW	lsp.sspcLpcLlccRcphhppLEtshsch...h+ps.p....th.ptps..ptph..........................................t....hh..shhs..cKVDuI-ahppclpcLs	.............................................................................................lshsspcLtcLscc.RcchhppLEth.sch...h+psp.....th.ptcs..ptph................................................................................................................................t..........hh..shhu...c+VDuI-ahppclpcL.....................................................................................................................	0	150	321	507
+14555	PF14704	DERM		Dermatopontin	Eberhardt R	re3	Jackhmmer:Q07507	Family	Members of this family mediate cell adhesion via cell surface integrin binding [1]. They also induce haemagglutination and aggregation of amebocytes [2-3].	23.00	23.00	23.40	23.00	22.90	18.50	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.01	0.71	-11.30	0.71	-4.25	29	166	2012-03-12 10:48:15	2012-03-12 10:48:15	1	26	61	0	112	165	2	137.80	28	24.10	NEW	NsacpshsapCssspulsslpShasN.tppDRRWsFsCsshus.t.ss.sssphsu...hNp..acpshsasC.....ssNhalpuhpStassstc......DRhWpatCpch..sss...ph..psCh.ps..sahNsacsslsas...........................s...ssspsIsGltS................hasss..pcDRcW+hpsCpl...sC	..................cpshsapCsp.spslstlpShasp.ptpDR...Wsa..t..Ctssst......tp.....ssp.shhp......lNp.....hs......tthshsC.....sss.thlsGhpSha..ssh..............DRcWpFhCsch..sst..................sshsCh.to..sasN..p.aspphshh...........................s.s.shhlpGhto.....................................hasss..pcDRpWpahh..Cph................................	0	78	82	94
+14556	PF14705	Costars		Costars	Eberhardt R	re3	Jackhmmer:Q9P1F3	Domain	This domain is found both alone and at the C-terminus of actin-binding Rho-activating protein (ABRA). It binds to actin, and in muscle regulates the actin cytoskeleton and cell motility [1-2]. It has a winged helix-like fold consisting of three alpha-helices and four antiparallel beta strands. Unlike typical winged helix proteins it does not bind to DNA, but contains a hydrophobic groove which may be responsible for interaction with other proteins [3].	24.00	24.00	24.80	24.20	23.70	20.80	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.16	0.72	-9.44	0.72	-3.99	49	232	2012-03-12 11:46:56	2012-03-12 11:46:56	1	6	126	2	163	217	1	77.80	45	36.18	NEW	hpVpcEltpLsphIcchGp........p..sss.GphsVpFGhLF..-phssl.-........t..LVGsLhsA+K+plVcF-GEhLhQGtcDcVsIsLL	..................................plp+EltpLsp.IcphGp.......c.stD..GphpVpFG.LF..-+hspI...-........t......lVGhLhtA+K+clVsF-GE.hLhQGtcDcVsIsLL..................	0	52	71	117
+14557	PF14706	Tnp_DNA_bind		Transposase DNA-binding	Eberhardt R	re3	CATH:1mus_A_01	Domain	This domain occurs at the C-terminus of transposases including E. coli tnpA (Swiss:Q46731). TnpA encodes a transposase and an inhibitor protein, the inhibitor only differs from the transposase by the absence of the N-terminal 55 amino acids, which includes most of this domain [1]. This domain consists of alpha helices and turns, and functions as a DNA-binding domain [2].	24.00	24.00	25.50	24.50	23.20	22.10	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.14	0.72	-8.68	0.72	-4.25	54	483	2012-03-12 14:11:11	2012-03-12 14:11:11	1	8	172	5	115	435	60	55.90	43	15.95	NEW	sWAppEhtpssLGDtRhscRLlplsppL..uppPstSlPpusp.shApscAAYRFhsNppl	.....tWApcphupAcLGDsRRs+RLlsLussL.......Ap+sGhSIspusp.shApscuAYRhlcNspV..............	0	23	63	79
+14558	PF14707	Sulfatase_C		C-terminal region of aryl-sulfatase	Coggill P	pcc	CATH:1auk_A_02	Domain	\N	25.80	25.80	25.80	25.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.93	0.71	-3.86	86	772	2012-10-03 20:55:17	2012-03-12 17:14:39	1	9	252	8	368	739	322	119.10	24	23.28	NEW	Ss+c.....hlFaYsust.............LhAVRhtp.......aKAHahT.shtspss..........................s.s.st.tlptH-P.PL.LFcLspDPuEphPL................ssps....spatpllpp.......lppshcpHppol.........s.s.sQhshhs.....hhhPhhpstp..h...s.ss.C	.................................+c..l.Fa.Y.s.sst.............LhAlRhtp.........aKsa...Fho.th..pspst....................................hhtp..hsppcs..PL...lFcLppDPtEph.s.l.................ssts..............s.a.ph.ltp.......hpthhtpa.psh...................h.........................................................................................................	0	105	153	227
+14560	PF14709	DND1_DSRM		double strand RNA binding domain from DEAD END PROTEIN 1	Godzik A	adam	Jackhammer:Q8IYX4 	Domain	A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)   	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.55	0.72	-3.69	24	349	2012-10-02 17:51:51	2012-03-13 07:27:26	1	29	109	0	202	525	123	73.20	32	9.36	NEW	psAsphLcplCpKNpWGpPhYplp.ppsGPcthhh.FhYKVhlPuhss...s....h...sschsssh--AKphAAphsLppLs	......tssphLp-lCpKppWssPpahLh..pssGPcppph.Fla+Vhlsuhsh.......................hh..sschpsthcpAKphAAphsL.tL.......................	0	40	70	122
+14561	PF14710	Nitr_red_alph_N		Respiratory nitrate reductase alpha N-terminal	Eberhardt R	re3	CATH:1q16_A_01	Domain	This is the N-terminal tail of the respiratory nitrate reductase alpha chain. The nitrate reductase complex is a dimer of heterotrimers each consisting of an alpha, beta and gamma chain. The N-terminal tail of the alpha chain interacts with the beta chain and contributes to the stability of the heterotrimer [1].	24.00	24.00	24.30	25.30	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.01	0.72	-3.71	73	1502	2012-03-13 09:33:31	2012-03-13 09:33:31	1	5	1099	12	150	902	20	37.10	58	3.07	NEW	HFLDRLpaFp+t......p.-sFusGHGtsssEsRsWEcuYRpRW	......+hLDRhRYFKp+.......s.ETFADGHGQlhpssRDWEDuYRpRW.	0	32	70	112
+14562	PF14711	Nitr_red_bet_C		Respiratory nitrate reductase beta C-terminal	Eberhardt R	re3	CATH:1q16_B_03	Domain	This domain occurs near the C-terminus of the respiratory nitrate reductase beta chain. The nitrate reductase complex is a dimer of heterotrimers each consisting of an alpha, beta and gamma chain. This domain plays a role in the interactions between subunits and shielding of the Fe-S clusters [1]	27.00	27.00	28.70	28.60	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-9.87	0.72	-4.46	141	1906	2012-03-13 09:34:22	2012-03-13 09:34:22	1	7	1444	12	235	921	18	80.90	52	16.13	NEW	LSPlhssspussh.....s......slhPslcsLRIPlcYLANLhTAGDstPVttuLcRhhAMRuYMRupslstp.D...tslhcpVGLotp	.................................LSPIpShs-AGsh...sss..............ulLPsl...-oLRIPVpYLANLLTAGDTtPVhpAL+RMhAMRpYMRupsVcs....hsD....spsl-cVGLot.t...............	0	59	130	189
+14563	PF14712	Snapin_Pallidin		Snapin/Pallidin	Eberhardt R	re3	Jackhmmer:O95295	Family	This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion [1]. It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting [2]. The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles [3].	25.50	25.50	25.70	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-10.17	0.72	-3.68	53	266	2012-03-13 14:00:15	2012-03-13 14:00:15	1	10	143	0	176	242	0	88.10	27	51.76	NEW	tptLupG..lhplhpPslcphcsplppltpsQppLtpplcpLspcLcchpc.pp.s.s..hshsp.YhpKLhsl++clhslpphlpplpcRht+lpp	...................h.p.lupG..lhshhtPslpphcpplpplpps........QstLhppl-p.s....sc...Lpchpp.tphs.h..hshsp.YhpKLhsl++chhhlpphhpplpcR.htcLp...........................	0	61	86	132
+14564	PF14713	DUF4464		Domain of unknown function (DUF4464)	Eberhardt R	re3	Jackhmmer:Q6V702	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 224 and 241 amino acids in length. There is a conserved YID sequence motif.	27.00	27.00	53.90	44.00	26.90	26.80	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.45	0.70	-4.95	44	173	2012-03-13 14:47:19	2012-03-13 14:47:19	1	4	102	0	115	188	5	188.30	38	93.70	NEW	hhs.slhpFsTYEDYLDShlo.pDhhYLpspclsRpLlc..LG.aRssupllpR-EFttp+pthctthps...................plsuh...Gcpl..pst.PhLpALApREchshstcLoTIIFlc.css+GpEISGYIDasppL+s..........psacshFpG+++........LhPpsoDLSaaNWcoppshhNsSsNapVls-st.pGLlF+pKtD+KlIsVssps..s.u-NspRsh.lposhYspVVlYDHhsR++s	......................lhpFtsY--YLcS.lo..DhhYLtspphh+pllc..LG.h+sptphhpc--F.tt+ttht.th.s................................htt........up.h..ps..shLhtLAtREc.shptpl...............ooIlFlp.pspp.G.ElSGYIDasppL+p............psacshFpt+++........LhPp.sDLSaasWcsphsh.NsosNa...........pVlscs....GLlFppKtD+KhlsVsspt....ucNspRp..l..o..Yh.slhaDHhhR+p..........................................	0	45	55	85
+14565	PF14714	KH_dom-like		KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	Coggill P	pcc	CATH:1mky_A_03	Domain	The KH-like domain at the C-terminus of the EngA subfamily of essential bacterial GTPases has a unique domain structure position. The two adjacent GTPase domains (GD1 and GD2), two domains of family MMR_HSR1, Pfam:PF01926, pack at either side of the C-terminal domain.  This C-terminal domain resembles a KH domain but is missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2.	25.30	22.20	26.70	23.70	25.20	22.10	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.45	0.72	-4.02	596	4526	2012-03-13 15:50:54	2012-03-13 15:50:54	1	12	4425	2	1039	3025	1279	80.60	40	17.34	NEW	RlsTupLNchlpcslttp..s.PP.s...p...G.+c....lKlhYsTQ......ss.spPPsFllF...sNp..schlptoYpRYLcNplRcsF.sh.pGoPl+lhhR	.............................RlsTuhLNcllppA..lttps.PP.s..p...G..+R...lKlhYAoQ.......su.spPPsFVla...sN.p.schlp.SYcRYLpNplRcs.F.sh.pGTPI+l.h+................	0	365	699	892
+14566	PF14715	FixP_N		N-terminal domain of cytochrome oxidase-cbb3, FixP 	Coggill P	pcc	Pfam-B_28684 (release 26.0)	Domain	This is the N-terminal domain of FixP, the cytochrome oxidase type-cbb3. the exact function is not known.	24.90	24.90	26.00	25.30	23.80	23.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.36	0.72	-8.82	0.72	-4.57	213	1066	2012-03-13 17:05:29	2012-03-13 17:05:29	1	15	961	0	306	849	102	52.10	41	16.65	NEW	tssspsoGHsWD...G....IcEhsNPLP+WWhahFhhTIlaulsYhlh.YPuhshhpuh	...........stpspssGHpaD...G.....IcE.hs.....NPLP+WWhhhFhsTIlaAlhYhlh.Y.Puhu.hpu.h.........	0	83	189	248
+14567	PF14716	HHH_8		Helix-hairpin-helix domain	Coggill P	pcc	CATH:1bpe_A_01	Domain	\N	30.00	30.00	30.10	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	68	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.15	0.72	-3.79	351	1491	2012-10-03 02:11:09	2012-03-13 17:38:04	1	43	1116	210	618	1303	285	67.70	29	13.24	NEW	Npcl..s.phL.pclAphhEhpt....ts..sa.+spAY++AApslcs.h.sp.slss...h...pt...tl.....pp.lsGlG...cslApcI.pEhlp	....................ppl.h...chL.cplAphhEhpt....ts..sa+lpAYR+AApslcs.h.sc..slsph....p-.........h........pp.lsGI.G......cphAphI.pEhl...........	0	202	354	498
+14568	PF14717	DUF4465		Domain of unknown function (DUF4465)	Godzik A	adam	JCSG structure SP13250B	Family	A large family of uncharacterized proteins mostly from  human gut bacteroides, but also some environmental  and water bacteria (Planctomycetes) as well as  metagenomic samples Most proteins from this family are secreted or  located on the outer surface and may participate  in cell-cell interactions or cell-nutrient interactions This function is supported by a solved structure of a Bacteroides ovatus homolog, which adapts a galactose binding (jelly-roll) beta barrel structure	25.00	25.00	63.10	62.60	22.00	21.90	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.50	0.71	-3.86	22	101	2012-03-13 22:58:36	2012-03-13 22:58:36	1	7	65	1	16	68	17	185.20	31	39.28	NEW	ssY......spaG.......t.h......uGauhostT-ss.....ossass...p.huuhsGtGps....sssh.hh....s.sas.uhst...shlth.........sshphcGhalTNooYshhshhpGssh.........ut.......tshp..c.s.DaFplolhGa..c.....ss.....ssl-hhLADaR..ssp...p.lVssWpahDLosLusssplpFphpSSDs..Gp.aG.hNTPuYFslDsl	......................h....sphG...t.....s.uuashSthsp.t......sssass...p.hus.h.....sts.Gps.......Gs.sa.sll...hGYssuaspt.......st.chh......................ssstplpGlalsNToYsYsshppGspa.............................sth..........sshpc.s.saFplslhshD.......ssG..hhpshchhLADYR.ssp.......s..lssWpahDLsul..s..s.VpslcFshcuSDs..us.YG.hNTPAYhClDcl....	0	13	16	16
+14569	PF14718	SLT_L		Soluble lytic murein transglycosylase L domain	Eberhardt R	re3	CATH:1qsa_A_02	Domain	Soluble lytic murein transglycosylase (SLT) consists of three domains, an N-terminal U domain, an L domain (linker domain) and a C-terminal domain (C). The L domain may be involved in the interaction of the enzyme with peptidoglycan [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.66	0.72	-9.33	0.72	-4.18	96	1072	2012-03-14 10:47:09	2012-03-14 10:47:09	1	2	1057	3	180	738	113	70.40	40	10.99	NEW	.pttlttpssltRlpELhthsc.........stA+pEWthLlsphs....p.p.p........pt..tLAtaAtcppWachuVpAoIpuKhWDpl	............................ss...tlspsPphARlcELhhhsh........cssARuEWspLlcstS....c.s.E........pttLA+YAasppWaDLoVpATIsuKhWDpL..........	0	31	85	137
+14570	PF14719	PID_2		Phosphotyrosine interaction domain (PTB/PID)	Coggill P	pcc	Jackhmmer:Q6ZT52	Domain	\N	25.40	25.40	25.40	25.40	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.44	0.71	-4.64	10	195	2012-10-04 00:02:25	2012-03-14 13:07:17	1	2	88	0	123	471	1	164.10	34	47.36	NEW	TYsVlYLGNVLTlhAK.GEGCl-KPLupIW+sYspp.+.sslpMKLsVosSGLKAsTcc.........+GLTEYWuHRITaCsAPscaPRVFCWlYRHEG++hKsELRCHAVLCpKpppAppluppLpppLpsALpEaKREKlp.....tQpA+Lshu.slhs..sPs.lP+RKLL..sGs..pNaRP.PVERSKSAPKLuSI-E-	...........................................apVhYLG..ps..sT.....ht.sp..G.cG.CT-csV.sc....l....W.....p+..p......p...u......+.....tss.....ph...c...Lplss...pGl..+h.p..p...h..-tt...............pps....h.c..t..Y..h..ltRIoYC.sA.D..tp.h.P+lFAWl..............YR.H........p.s....cc..............h....s..h........LcCHAVls.p+ttcActlAhhLhpshtpA..h..p.-.a.K..+.p+.........+ppt.......................................................................................................................................	0	38	48	82
+14571	PF14720	NiFe_hyd_SSU_C		NiFe/NiFeSe hydrogenase small subunit C-terminal	Eberhardt R	re3	CATH:1wui_S_02	Family	This domain is found at the C-terminus of hydrogenase small subunits including periplasmic [NiFeSe] hydrogenase small subunit, uptake hydrogenase small subunit and periplasmic [NiFe] hydrogenase small subunit. This C-terminal domain binds two of the three iron-sulfur clusters in this enzyme [1-3].	27.00	27.00	31.20	30.90	23.30	22.50	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.47	0.72	-3.95	163	2101	2012-03-15 09:29:21	2012-03-15 09:29:21	1	5	1192	65	410	1124	51	85.00	50	22.89	NEW	aupplH-s.C.RpsaF-tGtFscpaG-.ttt.GhCLaclGCKGPhTassCsphtWNt.ss..uaslpuGpPCIGCoEPsF.Dphssahpt	...........YGppIH-p.C.RRsHFDAGcFscpasD-utRpGaCLY+lGCKGPpTYssCSohcaNs..Gs..uaPlpuGHsClGCsEsGFhDctu.a...hh..................................	0	144	296	359
+14572	PF14721	AIF_C		Apoptosis-inducing factor, mitochondrion-associated, C-term	Coggill P	pcc	Jackhmmer:JCSG-Target_422903	Domain	This C-terminal domain appears to be a dimerisation domain of the mitochondrial apoptosis-inducing factor 1.  protein. The domain also appears at the C-terminus of FAD-dependent pyridine nucleotide-disulfide oxidoreductases. Apoptosis inducing factor (AIF) is a bifunctional mitochondrial flavoprotein critical for energy metabolism and induction of caspase-independent apoptosis. On reduction with NADH, AIF undergoes dimerisation and forms tight, long-lived FADH2-NAD charge-transfer complexes proposed to be functionally important.	25.90	25.90	25.90	25.90	25.80	25.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.78	0.71	-3.91	23	200	2012-03-15 13:49:27	2012-03-15 13:49:27	1	9	126	9	116	198	7	98.30	44	20.11	NEW	AGENMTGAtKPYhHQSMFWSDLGP-lGYEAIGlVDSSLPTVGVFAKuospD.......sP.cusscsossslpscspspussssstsssps.sss.t.......tt....-DaGKGVlFYLRDcpVVGllLWNlFNRhslAR+llp-s	....................................................................AGENM.sG.A...t.......K..P..YhHQSMFW.SDL.GP-lGYE..AIGllDSS.L.sTVuVaAcsotpp.........p....tt..t...............................................tcpasKGVlFYL..+.sc..hVVGllLWN...lFs.+.hslARplltp.s......................	0	49	64	92
+14573	PF14722	KRAP_IP3R_bind	SSFA2_N;	Ki-ras-induced actin-interacting protein-IP3R-interacting domain	Eberhardt R	re3	Jackhmmer:P28290	Family	This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein) [1].  This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells [1]. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [2].	27.00	27.00	28.10	27.20	21.70	25.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.88	0.71	-4.66	8	175	2012-03-15 14:06:43	2012-03-15 14:06:43	1	4	68	0	90	165	0	137.00	44	18.07	NEW	.hhs+GpShNSou.SusousTsSSlSElL-hapEDsEElLasLGFGpDEPclso+IPuRFFsssSsA+GIsh+lFLcuQlpRIchEsPshuLsSRFRQlElLssVANAFSSLYSaVStpPsQKlussch.......E.hshssPlp+pS....p...cspusht+ltsp...s	..........................................hhphGpShsSst.st.pouussS.SlsElL-hhccDPE-ILhsLGFG.....p.....-.E.sDlsS+IPuRFhsssStA+GIDhclFLpAQh.pRh-hEsPs..LhuRF+QlphLshsssAF.sLhs.VSths.pt................hs....shphss......................s..............................	0	12	20	45
+14574	PF14723	SSFA2_C		Sperm-specific antigen 2 C-terminus	Eberhardt R	re3	Jackhmmer:P28290	Family	This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2 [1].	25.00	25.00	25.70	25.70	22.00	21.70	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.14	0.71	-4.54	5	106	2012-03-15 14:07:22	2012-03-15 14:07:22	1	3	38	0	47	107	0	157.40	49	15.79	NEW	HhsospTHSVPhsSGh.....uuSsHhoPAuCsaSs+HsPaPapspusssPssshst.......tplEMQLRRVLHDIRsThQNLuQ.s.h+G.Dhshs..hsT.p.SVpPLYEsThpELQshRRsLNlFRTQMMDLELAhhRQQoLVYpHMSEEERcEA-QLQTLRcAVRQELQELEhQLEDRLLuIcEQl	.....................................................................Hhtp..T+SVs..SGh.....ssosassPhtCshsp+H.tsasa.p.pssss..Pss...............lEhQLp+sL+slpso..........................oV.h.Lhp.sThpEhpsMRpsLshFRpQhh-LEhshhcQQshVY+HMoEEERhEs-QLQoLRpuVR.Elp-LEhQLp-RlhtlcEpl...........	0	3	7	16
+14575	PF14724	mit_SMPDase		Mitochondrial-associated sphingomyelin phosphodiesterase	Coggill P	pcc	Jackhmmer:Q9NXE4	Family	The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.	23.70	23.70	24.20	23.70	22.10	23.60	hmmbuild  -o /dev/null HMM SEED	765	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-13.23	0.70	-6.74	4	286	2012-03-15 16:48:53	2012-03-15 16:48:53	1	4	90	0	124	270	0	315.60	27	82.32	NEW	QPSFLLAoLKADslsKPFhQpCQDLV+VIEDFPAKELHsIFPWLVESlFGSLDGsIVGWNLRsLQuRhNPsEYslsh-FLDPSGPMMKLVYKLQAE-YKYDFPVSaLPGPVKASIQEpVLP-CPLYHNKlQFPsSGGluLNLALNPFEYYMFaFAhSLITQKNhPluhHlSouDSAYFILVDpYLKaFLPTEGSVPPP.SossGGolPSPsPRoPulPFsSYGhHHTSLLKRHISHQsSVNADPAuQEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPphKLElLHYRLSlSShhh.sPhps.u.tuLHuYQEsFpPTEEHVLVVRLLVKHLHAFSNSLKPEQlSPSAHSHTsSPLEEhKRVVVPRFVQQKLYlFLQHCFGHWPLDASFRAVLEMWLSYlQPWRYssEKssPso.-.psRsVsEKWusFVQENLLMYTKLFlGFLNRsLRTDLVsPKNALMVFRVAKVFAQPNLuEMI.KGEQLFLEPEhVIPHRQHRLFhoPshGGSFLSuW.PslTDsSFKVKSHVYSLEGQDCQYpQMFGsEsRsLVL+LAQlIsQA+QTAKSISDpSAEosAspSFhSWFGhuSsDhNGSYsGsDLDEhGtDol+KTDEaLEKAL-YLCQIFRLNtuQLsQhhhslGouQD-sGKKQLPDCIpuEcGLILTsLGRYQlINGLRRF-IEYQGDPELQPIRSYENAhLVRhLaRLSSslNcRFAspMsALCSRcDFLGphCRaHLTsPthsp+t+hSPltpcps.ucstuPRlSLR	.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	44	55	91
+14576	PF14725	DUF4466		Domain of unknown function (DUF4466)	Coggill P	pcc	Jackhmmer-JCSG:target_419245-SP18803A	Family	\N	25.00	25.00	394.90	394.70	21.50	19.70	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.00	0.70	-5.14	6	11	2012-03-16 11:55:18	2012-03-16 11:55:18	1	1	11	2	3	13	0	315.10	48	94.39	NEW	ACcDp.....-scSsL+NDhIK+Tl..uPslsGpcIEFAYAMu..sppG+lssApscASIAGAsGThF-hpSaYT............uoGpDVPVQsscDusTsGssoTsshhccss..................AATLRYaYllPc-A+GKsVSFoFSApSSsGpplSYphssY+ISKMDMK+slslpNtsACYlSltD....MpsYTKt-VssN.sLAsKIDhlYlYp.plsshDasHAhVoPuosscYls.ushlPuGhsNs.TthcKphsV+DtQLpshph.uVYIDDlDFcplDhusAsDYslsL+p-sGAaVcTADGKYtAYVYlNplssSuKphTVSlKRYsL	.....uCp-......-scssL+NDhIK+Th..GPslVGppIEFAYAMu..spcG+lssApsEASIAGAsGThh-ppSaYT............uoG.DVslQsussolTsGssoTsshhccss..................AATLRYYYllPEEA+GKsVSFoFSApSSsGppVSYphssYcISKMDMK+slslpsuuuCYlSIAD....MpsYocs-lssN...usKIDhVYlYp.plsshsFsHAlVoPuusspYls.uVpLPuGlsps.TtlcKthsV+DtQLtthph.uVYIDDlDFpplDhssAssYAlNL+p-sGAaVcTADGKYtAYVYlNslssouKphTlSlKRYsL	0	3	3	3
+14577	PF14726	RTTN_N		Rotatin, an armadillo repeat protein, centriole functioning 	Coggill P	pcc	Pfma-B_645 (release 26.0)	Family	Rotatin and its homologues such as Ana3 in Drosophila are found to be essential for centriole function [1]. A deficiency of rotatin in mice leads to randomised heart tube looping, defects in embryonic turning [2], and abnormal expression of HNF3beta, lefty, and nodal. Thus it is required for left-right and axial patterning. Ana3 - the Drosophila homologue - is present in centrioles and basal bodies, is required for the structural integrity of both centrioles and basal bodies and for centriole cohesion. Rotatin also localises to centrioles and basal bodies and appears to be essential for cilia function [3]. This family represents the N-terminal domain.	25.00	25.00	26.30	26.30	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.23	0.72	-3.42	25	85	2012-03-16 13:05:11	2012-03-16 13:05:11	1	3	68	0	57	75	0	97.60	43	5.77	NEW	tEIRhRALcsIpsKlp+sLlphp-ls.ppp.LL+pLlc..WFsassss.tp-cVLsLlpc.LhcpshuspllpclGs.cF...Lscl+....phlssph.ptplppllcsL	.......EIR.RAL+sIlsKl-HsLlshsDLl.pc+hLhlpLLE..WFNFsslP.hp-EVLsLLpc.LlKaPsAsphLh-lGAl-F...LocLR....ssl-Ppl.pscIDslLDsL........	0	17	21	35
+14578	PF14727	PHTB1_N		PTHB1 N-terminus	Eberhardt R	re3	Jackhmmer:Q3SYG4	Family	This family includes the N-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis [1].	25.00	25.00	27.50	27.00	23.40	21.20	hmmbuild  -o /dev/null HMM SEED	418	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.26	0.70	-5.52	25	181	2012-03-16 15:04:53	2012-03-16 15:04:53	1	9	114	0	104	189	5	348.90	39	50.44	NEW	MSLFKsR-WWoopssp.sEcaDp.usLsVuNlDNssstp.......DpIlVG..SasGhLRlYpP.........ppssacsp.DLLLEppLppPILQlphG+F.........luus.pslpLAVLHP++LslYsl.....pshsGp..sppust.......hpLpLhYEHpL......p+sAhNhshGsFGGscs...........+DhlCVQShDGtLpFFEQ-shuF.s+hLss.aLLPGPlsYss+sDSFVTsooshpl-sY+.........YpsLAsuspsppppt...p...........................su++lsssWohslGEpsl-Ip.................lsphsp....spssIlVLGE+oLFslccsG.pl+a.K+L.-asPsshhsYss..hscsshp........................lllsocospLhlYpDssLtWuAph...spsPVAlpsusht.............sl.pGhlVsLspsGpLpssYLGT-P...........shhhsPshp..s+-hsY-chpcEhpcLpclI+pussspch.......psccclplpsplsspl-	.........................MSLFps+-WWss..hs..tEpa....c....t...u..sLhlushsspts.t..p......................DpIlVG..Sh.Gh.LRIapP..........ptpshpsp.clLLEsplp.tPlLQltsG+F..........lssp.p....pLAV.Lps+plslYsl..............tth.Gt....hthusp.............................hphplhaEHpL......p+sAhshshGsFGssps...........+chlClQShDGhLhhaEQ-shs...............F.sphLPs..hLLPGPlsYss+oDoFlTsoSshplpsY+..Yps.Luhussttt..................................ss+plss-WohslGEpslDlp.................lsphsp................stsslhlLGERshasLc-.s.G.pl+ah++L.-hsPsChh..s...Yss...hppsshp........................hlluscsshLhlYpDssLtWuspl...sthPV.Alplushp.....................................sl.cGhIVoLussGpLpsuYLGT-P...........sha.p.ss.lp..s+..pl.sYpphphEhpcLpchI+chptstsh.......pttcpltlph.l...........................................................	0	45	55	82
+14579	PF14728	PHTB1_C		PTHB1 C-terminus	Eberhardt R	re3	Jackhmmer:Q3SYG4	Family	This family includes the C-terminus of PTHB1 protein. This protein forms a part of the BBSome complex, which is required for ciliogenesis [1].	25.00	25.00	33.70	25.20	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	377	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.16	0.70	-5.67	6	158	2012-03-16 15:10:26	2012-03-16 15:10:26	1	7	107	0	92	177	5	312.30	34	42.03	NEW	solKlsl+s+hphppspLolssptP..LslopDshhFcslus.tho+shshslYl..psshhPssLpsplVsSYsosp.....GlPRllQppspLPL+LhhcPsQPsKsAsHKLTlssNpsPVs......LhsLFPEFhp..EcusssAlGFQhlu....Gp+..VTlLAuKoSpRYRlQSDpFEsLsLlscchlhRh............ccpas+pshhDtF..plohuGshPlpphh-hIDsHF-lRhshccLcspLpptusQaRsIQRRLls+FK-KoPsPLpsL-hLL-uTYsplhtluDplcEhccsLh+utscLsuuspLllLlltLhhsL.ssctlplLEushsPllhDhpE.uWEEhsDAuloaLL+TsLuKSSK-Quhs..........hpsshc.PpDsS........+L+KHlshlsDRls	.............................................h.hp.t...hptspltl.st.P..l.hspsp.h..sh..p.hss..t.spp...hthshah....ptth....Psphcsphss.oasp.sp...........G.....hP+llQpphpLPLpLls..hssp.PsKsA...sa...KlTlc.TNp.s.sls................LhslF..........s.t.Fst............pc....s...ps...ssh......Ghphls.................Gsp......lTlLASKsSp..R.YRIQS.-phEsLaLlspELlhRl...........................................pph..hpc.t...hs..h....thsh.s.....ssh...P.........lpcaachlDpHac.lRhphcchpchLscpAhQFRu.lQ+RLLs+a+-+sPssL..p..tL-sLL-sTY..cplhths-thpp.ptphhpthstLpssspLh..h..hllth...p.h.p.pththlpshh.s...p.............p........uWEE.stsulshLlphs..pp.pttt..................s...t...sht........ph++phshhh-+h.....................................................	0	35	45	71
+14580	PF14729	DUF4467		Domain of unknown function with cystatin-like fold (DUF4467) 	Godzik A	adam	JCSG target SP18127A; Pfam-B_491 (release 26.0)	Family	Large family of predicted lipoproteins from Gram-positive bacteria Experimentally determined structure shows a cystatitin-like fold, allowing us to classify this family in the NFT2 clan, despite lack of any detectable sequence similarity between members of this family and other families in this clan	21.90	21.90	23.90	30.30	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.19	0.72	-3.66	24	517	2012-10-03 02:27:24	2012-03-18 08:21:19	1	1	217	2	13	123	0	94.00	44	78.01	NEW	YsccIDclhKhppcppcch.tp.s.scsppc.a-+ccuNhYVY-cGKhIllu.Yp.hK.sscpl.hYhhYchps..cKhph.ccch.....s..s+pYhccH.cPDY+EpN	..YpK-IDcshKlQspppcph.uKhs.schhschc+cDuNhaVYccGKlIllu.Yp.hp.sc-ch.aYaAY-hpD..cKsph.pp-h.....D..sc+YhppH.cADYc-EN..	0	3	3	11
+14581	PF14730	DUF4468		Domain of unknown function (DUF4468) with TBP-like fold	Godzik A	adam	Jackhammer: JCSG target SP13279C	Domain	A large family of (predicted) secreted proteins with unknown functions from human gut and oral cavity.\	Typically forms a N-terminal domain with FMN binding  domain at the C-terminus. Experimentaly determined 3D structure of this domain shows a variant of a TATA box binding - like fold, but no detectable  sequence similarity to other proteins with this fold	22.60	22.60	24.50	24.10	20.90	20.60	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.89	0.72	-4.29	50	160	2012-03-18 18:57:27	2012-03-18 18:57:27	1	3	125	0	29	156	6	92.60	26	32.94	NEW	aopplpssuh..op.splYsphhpWhsphhps...h.sSplshssccpGhIsupu..pthllFs.....s.shLS.....ls+sphpYpltlcscDs+hclohoclp.YpYp	.........Fscphpls.uh..Sp.spIYcphhpWhspphpp..........t.sS+lshsscpcGsIsupG..cchl.lFs.....s.sslu.....LD+splpYplplsCc-s+splphscIp.YpY............	0	13	24	29
+14582	PF14731	Staphopain_pro		Staphopain proregion	Eberhardt R	re3	CATH:1x9y_A_0	Domain	This domain is the proregion of the cysteine protease staphopain. Like many papain type peptidases, staphopain is synthesised as an inactive precursor and cleavage of the proregion is required for activation. This proregion has a half-barrel or barrel-sandwich hybrid fold. The proregion blocks the active site cleft of the mature enzyme on one side of the nucleophilic cysteine [1]	27.00	27.00	47.30	46.60	23.30	22.60	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.13	0.71	-4.49	6	356	2012-03-19 09:54:49	2012-03-19 09:54:49	1	2	195	4	4	96	0	167.80	64	43.35	NEW	KpscVNVcsKcVPpcV+cLApcQYLSaVsuLDKtSNpcsuuYTLGEsFKIYKFNpcSDGNYYYPVLNK-GcllYlVTISPKssss.KtSppsusYSINVSPFlSKsLNQYKsQ..pITILTspKGYahhsEDsKl+LVLKTPhsssKppKpsscpsss+.hpphKQTuolTK	...KplplNVcscpVPpcV+sLAQppahuYspuLDK..N..t.cpupYpLGEsFKIYKFNtcpDssYYaPVl..p-GpIsYhlTlSPKsp...ppSpps.pYolplSsFluKsLsQhKDp..pIT...lLT.spKGaY.hppstKs+LVhtTPh.pshK.Kcotphsoup.hppLKppsosTh.........	0	2	2	4
+14583	PF14732	UAE_UbL		Ubiquitin/SUMO-activating enzyme ubiquitin-like domain	Eberhardt R	re3	CATH:1y8q_D_03	Domain	This is the C-terminal domain of ubiquitin-activating enzyme and SUMO-activating enzyme 2. It is structurally similar to ubiquitin. This domain is involved in E1-SUMO-thioester transfer to the SUMO E2 conjugating protein [1].	27.40	27.40	27.50	28.00	27.30	27.30	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.67	0.72	-3.88	74	271	2012-03-19 13:18:53	2012-03-19 13:18:53	1	9	228	6	191	271	5	89.30	29	14.34	NEW	pltlsspchTlpcLl-clL+ppLuhspP-lhl...ssslla-s--..........t.hssshpKpLu-l............GlpssohLslpDhpQc......hplplhlpcpcphcp	................lplssc+sTlpsLh-cll.....KpcLuhst.......P-lplp....spuslLhss--..........t.h-sN.pKpLu-h............Glp..sGo..hLpscDh.p-......hsl.l.lhcpcp...t.................................................	0	58	97	153
+14584	PF14733	ACDC		AP2-coincident C-terminal	Woodcroft B, Eberhardt R	re3	Woodcroft B	Family	This family is found at the C-terminus of apicomplexan proteins containing the AP2 domain (Pfam:PF00847).	25.00	25.00	25.10	25.30	24.00	22.80	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.84	0.72	-3.86	28	106	2012-03-22 12:53:11	2012-03-22 12:53:11	1	4	11	0	100	116	0	94.70	22	6.97	NEW	sssptLpltKpAlphlLpDLppsClspl...tthts.............................hpphlptHlphlpsu.tshpplhsYlplFssplppshLPSshshptQthllpuL	.............................................................................................t.tphlpltKtAlhhlLpDLpppshsph.....hh.s...................................................................hp.hpphlctHhphlpsu.pshppltsYlplFspsIppppLPSphshptphhllpuL.....	0	37	47	88
+14585	PF14734	DUF4469		Domain of unknown function (DUF4469) with IG-like fold	Godzik A	adam	Jackhammer:JCSG target GS13689A	Domain	A C-terminal domain in a large family of (predicted) secreted proteins with uknown functions from human gut bacteroides	22.60	22.60	22.60	23.10	22.30	21.40	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.24	0.72	-4.15	29	126	2012-03-23 06:08:24	2012-03-23 06:08:24	1	2	44	0	33	111	1	97.60	31	43.92	NEW	IspVsDssTGptssslTsGtshplpGsplKls.Gs-......susGlhhss.........ppG........s.htlssshlstNpPSpLhhhlPstLssGp.YpLplsTpauu.usphLKssRospa	......................tlpD.sTttts..GslTsGtshhlpGpplKls.Gs-......s.ssGlhhss.........ppu........s.stlshs.lshNsPSclhhhlPssLscGp.YpLplsTQaus.ssphLKsPRoh.................	0	15	30	33
+14586	PF14735	HAUS4		HAUS augmin-like complex subunit 4	Eberhardt R	re3	Jackhmmer:Q9H6D7	Family	This family includes HAUS augmin-like complex subunit 4. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].	25.00	25.00	25.90	25.20	23.80	22.90	hmmbuild  -o /dev/null HMM SEED	239	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.44	0.70	-5.06	12	109	2012-03-23 08:46:42	2012-03-23 08:46:42	1	3	76	0	61	109	0	209.10	34	62.65	NEW	stphsspsshsss.stlLGlsttpLhphhssp.sh.....thptpL.pElEppL+cKC.sLlsaapPsspssucshptsKss+Lsphlctcp..cphpptctphpcshhhhc+phppYhpsLhpsLplLppllp-a+LcpQs-hDchpppaLpsKC-sMhhKl+s.phplLpDTYTtEolsAh+pIRchLpsAhcptcp-hppupptLpsYEslG.cF-slscEYsclhpcl-s+pWsLpclpps	......................................................................................h.p.....tss.tt..s.hLGlp.t.Lhph....p....sh......hptpL..ElEtpL+pKC.....sLhshas.ss.......pssup..th.ptspsh+LsEhlhtth..pphpctcs.....t.pEph.hhh-+p.upY.pVL.ppLslLpp...Ll...p-p+LcpQ......schDchptpaLph+CpsM.hKL.Rh.Ehc......lLp-.TYT.sEpltsh.+h.IR...cpLptuhc.tppphpcupph.LpsYc.sls.c.........F-p..........ls+pYpplhpthEshp.Wslpphph..............	0	16	30	44
+14587	PF14736	N_Asn_amidohyd	N_Asn_aminohyd;	Protein N-terminal asparagine amidohydrolase	Eberhardt R	re3	Jackhmmer:Q96AB6	Family	This family of enzymes catalyse the deamindation of N-terminal asparagines in peptides and proteins to aspartic acid [1-2].	24.00	24.00	24.00	24.10	23.90	23.80	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.78	0.70	-5.53	19	160	2012-03-23 10:23:26	2012-03-23 10:23:26	1	4	114	0	93	169	0	232.10	37	83.22	NEW	thtSpsspsVsstslLYVpQREaAsT...sPpDpsVsllGSDDATTChlVVlRHTGSGsssLAHhDGos.Tcsulshhlstlpshs.s...tpGRLElHLVGGFpD.................scphScpLshpILpuFc+pp--IHLpTsClsEhNshlc.sGlphPllYGIuVNlKTGclFPAoF..ss+GPDctLRpARhh.......ssuphlslYDsppphl+IGPhpasPhhs..sshWLppsDchILppLSTSPtsEPPHFVppl+uslpFlh-HPps.sslFPcspP+ha+Rsc.sGpWc+l	...........................................t...p.sss.thLYVtQREhAss......sP.t.s....tpl.sl......lGoD-ATTChlVVlR...csusG......s...ssLsHhD..........uss.scttls.hhpplpshs........puRlEl..HLlGGFsD.......................s.cthSppL..s...hpllptFccpp.....c.....lc....Lho.hCVs..-hNsh..............c....st.......phPllaGluVsl+Tucla..AoF......s+GP-c.LRtARhh...........sst.hlsl.YDspht.l+IuP..hsapPh.t....ssha...LppsDp.lLpphSTSP.sEPPHFltphRtslhal...cp..s..thF.s.ppshhac+sp.sGh..W...........................................	0	32	46	69
+14588	PF14737	DUF4470		Domain of unknown function (DUF4470)	Coggill P	pcc	Jackhmmer:Q8N9W5	Family	This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, Pfam:PF01753, at their very C-terminus. Others are also associated with DUF1279, Pfam:PF06916.	25.00	25.00	27.80	26.10	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.40	0.72	-4.27	100	314	2012-03-23 14:25:58	2012-03-23 14:25:58	1	21	155	0	250	334	1	98.50	23	12.55	NEW	haGsos...Ahsl...hpp....................tt..s.ppslslLhh..GsG.DhRpllpTlsshs.pp.p............p...lplhlsDts....tllARNlllLpl.....lhs.s......ppssphhhc.laasshls	.....................................................................hG.osAhslhp.........................................s.ppslslLlh.............G..sG.DhRplltTlspt..tp.tt...........................plphhlh-hs.pllA.RslllLpl......hhc.s...................pptsphhhclahshhh...................................	0	118	170	216
+14589	PF14738	PaaSYMP		Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1	Coggill P	pcc	Jackhmmer:Q7Z4T9	Family	PAT1 (proton amino acid transporter 1), also known as TRAMD3 of AAT-1, is the molecular correlate of the intestinal imino acid carrier. It is a proton-amino acid co-transporter having a stoichiometry of 1:1. Due to its mechanism, PAT1 activity increases at acidic pH, which correlates well with the acidic micro-climate close to the brush-border in the intestine. Glycine, proline, and alanine are the preferred substrates of the transporter. The maximum velocity is similar for the three substrates. All substrates are transported with low affinity, showing Km values in the range of 2-10 mM. The transporter does not discriminate between L- and D-isoforms of these amino acids; in addition, beta-alanine is transported with similar affinity as alpha-alanine. Similar to the IMINO transporter, the amino acid analog MeAIB is recognized by PAT1. The transporter is strongly expressed in the small intestine, colon, kidney, and brain.	21.60	21.60	26.40	21.60	19.10	18.80	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.97	0.71	-4.49	32	172	2012-03-23 16:23:11	2012-03-23 16:23:11	1	10	109	0	105	175	2	146.70	38	20.68	NEW	usQT.YRES-AQTsPYoP..-.aslp.s.ss...sP..ElLsLssLpasc.G.L.PuGhtEVEhIERARc+RsaEssLP.s..........hs....Dts..ph...p......pR...+phh-t.hEhcEWthREp-IpchQchRL-llpchlpcREcppcphsppRl-phtpphppc+pttlp+lctctl..cthR+	.............t.sQT.YR-u-sQTsPYpP..Ehhspp.ss...hs..............ElloLusLpa...........uc..G.......L...PsG.tEVEhIERARcKRAaEssLPs..........hsDts....ph...p.......cR+chhpthEhcEWt.REp-Ipc..lQchRL-llpchLccREcpppphstpRl.ptthpphpcp+ctpltplphphhpshR+..........................	1	44	53	77
+14590	PF14739	DUF4472		Domain of unknown function (DUF4472)	Coggill P	pcc	Pfam-B_085261	Family	This family is specific to the Chordates. Some members also carry Kinesin-motor domains at their N-terminus, Kinesin, Pfam:PF00225.	22.70	22.70	23.40	28.70	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.78	0.72	-10.25	0.72	-3.59	12	44	2012-03-23 16:37:54	2012-03-23 16:37:54	1	2	35	0	29	51	3	107.70	38	21.45	NEW	SEEp+LpISKELVDLQIcsp+l+EQaEAEhFELKNc..................lLpLEsRlLELELct-.....phststsshtcphphspp.p+chttphh.h+pph.s.spsh.p.pscpccLu.pL.	.SEEp+LQISKELVDLQIpTp+LpEQaEAEhFELKsc..................lLpLEsRVLELELcs-.....pss..spss.tctht....spc....+pchtsphh.hcpph.s.scsh.s..tcppcLu.tL.h...............................	0	10	13	18
+14591	PF14740	DUF4471		Domain of unknown function (DUF4471)	Coggill P	pcc	Jackhmmer:Q8N9W5	Domain	This family is conserved from fungi to Metazoa and includes plants.  The function is not known, but several members have zinc-finger domain, zf-MYND, Pfam:PF01753, at their very C-terminus. Others are also associated with DUF1279, Pfam:PF06916. This domain is more C-terminal in many members to DUF4470, Pfam:PF14737.	25.00	25.00	26.40	26.20	22.50	22.30	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.83	0.70	-5.18	18	137	2012-03-23 16:41:55	2012-03-23 16:41:55	1	9	98	0	86	142	4	253.10	29	55.42	NEW	hlslptLKaKERDtLEthFpaWpst...ppsaclschW-...pRlRphLGsRYDpRsGlaDWDhsMpL+-.ptup.IssQEYRpWRcsGlAFsa.......sE.t.-aspPNKThssuhl...psGpsahpRGYlGDIpTGPFhuFG...lcss-.....E+h.h+ohcG.....pscapuTDloE+Nlhplh........aELp.....sp...........ssap.hsts...........-....................sps.p..th..psptsh....sp.p.....hhsstpVpl+Fl.slph.lchhpp.+p+apphFDllFlups.hspaLpss....hhp.sh..+ss.AllllETt+alssh+K-phppatscl+clh+pushcsstshs	...................................lslptLKa+ERDtL-thhphWt........t........ps...........ashsphWD...pRlRphhupRYDtRpsh...hDWDhp..MpL+c..pt........uphIp.pcaphWRpsGlAFph..........................h-t.tYp.hPN+Thsshhh............pp.............GpphhtRGYhGDIhsuPahuFG....lcspc.....pph.hph.ps.....p..hsut-lspcNlh.phh........hpltst..................ttht.hs.t..........p........................................................................................................tp.t..t......tt.t.........t.......h......thplpal.sh.s..hpp.l................p.+.ppa......pthFphhahuss.hsphlpsp..........htt.hh.......tst..uhlhhEht.pahhshpp-phtta.ppltchsptsGht......s.......................................................	0	38	48	71
+14592	PF14741	GH114_assoc		N-terminal glycosyl-hydrolase-114-associated domain	Naumoff D, Coggill P	pcc	[1]	Domain	This short domain is also a very small family found at the N-terminus of GH114, glycosyl-hydrolases.	22.00	20.50	22.90	38.90	18.10	18.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.67	0.71	-4.42	9	17	2012-03-23 18:28:37	2012-03-23 18:28:37	1	5	7	0	16	17	0	124.80	26	28.58	NEW	shssp-lssopDshspYlchus.........GuphphpFshPu.husssstsLslsssht.s.ttSutcWph-hash...ssssWsplGD.utAsShsWosssLsls.ssst.cFV.ussplplphs...psssspushlDh	.......hsstshssotDs.sp.lchus.........uuphphhFshPu.sus....sphhololsspht.ssttsuscWph-hasa....sussWsplGD.otssohsWosh.sLsls.ssP.....s.sFl.ssstlphphp...psusspu.hlD...........	0	13	14	15
+14593	PF14742	GDE_N_bis		N-terminal domain of (some) glycogen debranching enzymes	Godzik a	adam	Jackhammer:YP_001865398	Domain	This domain is found on the N-terminal of some glycogen debranching  enzymes and is usually followed by the GDE_C (PF06202) and in this  sense it is analogous (but probably not homologous) to the GDE_N  (PF12439). Its exact function is unknown	22.10	22.10	22.80	41.80	21.10	22.00	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.38	0.71	-11.12	0.71	-4.93	158	381	2012-03-25 04:19:21	2012-03-25 05:19:21	1	3	312	0	197	416	23	191.80	27	27.41	NEW	sL+cussF.hls-ppGDI.......s..ssspGLahpDTRaLSchpLplsGppshh...L.uusspps.ttshh..tlss..........l.t.s...st..hscsslplpRpRhl.t...su..hhEclslpNasspssphplplphsADFsDlFEVR..Gtp.ct..c+Gphh...sp..h.ps.s...p....................lthpYpG.D.....shpR.poplph.....t.........s.sssp...lss............sp....hsaplpLsPppphpltlpl	.......................L+pussFhlsDtpGDl.......tsssspGLahpDTRhLSphpLplsG.....ptP.h...L.uusspps.t.tuhh.pLss..........l...t.s...st..hscsslplcRpRhlt................ss..hhEclslpNasspssplplslphsADFsDlFEVR..Gsp.ct....c+Gpht...sp..spss...t.........................l.php.YpG.D.....shpRssplph.......p...........stPsp..lss..................................sp....ssaplplssptphslhlp..........................................................	0	54	119	159
+14594	PF14743	DNA_ligase_OB_2		DNA ligase OB-like domain	Eberhardt R	re3	CATH:1fvi_A_02	Domain	This domain has an OB-like fold, but does not appear to be related to Pfam:PF03120. It is found at the C-terminus of the ATP dependent DNA ligase domain Pfam:PF01068 [1-3].	25.00	25.00	25.00	25.10	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-9.01	0.72	-4.30	136	673	2012-03-26 11:48:33	2012-03-26 12:48:33	1	11	649	7	120	539	455	66.90	42	21.06	NEW	.G+GKapGhhGALhl..............ch.ss.....G..hcFclG.....oGFoDpp...RpsPP...........lGohlTY+YpGhT.psG.....hPRFssFlRlR	...............GcG+apGthGAlls..............ch..ts.....G......hpFpIG..SGasDp-...RcsPP.......................hIGollT..Y+YpGlT.p.pG.........hPRFssFlRlR..................	0	40	76	108
+14595	PF14744	WASH-7_mid		WASH complex subunit 7	Coggill P	pcc	Jackhmmer:Q2M389	Family	This family is the central, conserved region of proteins that form subunit 7 of the WASH complex [1]. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes [2].	25.00	25.00	32.10	31.60	20.30	20.10	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-11.96	0.70	-5.60	29	153	2012-03-26 12:33:06	2012-03-26 13:33:06	1	10	116	0	104	160	4	310.00	48	31.51	NEW	FLYWpR.slh.Phahpplacsshpsp..+l.ahhsAhpDshshltt.........spHhps..stslhcs.....apct.lhpplcccllcPLCpclEs-LRLpsHu.cL...phs.spsPhps....s....hp..Dlsp...hl.plsPl+hhsphlsl+pclE+YLspTFYNLsslAhHDWKTYtEMRsLApp+YGLphh-s+LPsQTL-QG.LDVLcIMRNIcsFVu+YsYNLNpQlFlEc..sS..s...uKHLsTIsI+HIANSIRTHGsGIMNTTVNasYQFLpKKFhlFSQFLaD-aIKSRLlK-hRaa+cp.+cp...hs..tpYPa-RA-cFt+pI+KLGl.......sss...GpoYLDpFRhLITpIGNAlGYVRMlRSGGlchsucuhpFlP.slpsh.ssap	................................................aLaapR.shhPhahpplappshpst..pl...YhhsAhpDshs.hhp..........upHhps....p.Llps.....appp.lhphlpcpllc.LCp-IEpDLRL.psHo.HL....pls.sp...sPh.cs.................u..h+..Dlsh....ah..plpPl+.hhscalcl+.shVp+YL-psFYNLoTlAlHD..WtTYpE.MRs.LApp+YGLths-sHLPsQoL-.........QG.LDVLpIMRNIHlFVupYhYNLNsQlFlE+..sS...........s........sKHLsTIsIRHIANSIRTHGTGIMNTTVNF.sYQFLppKFhlFSQFhaD..-+IKSRLlK-hRaa+Eh.K..cp....................ts....ppYPa-RA-+Ft+sIRKLGl.........................os-...GpoaLDpFRpL......IopIG.NAhGYlRMlRSGGL+ssusuhpFlP.chcs............................	0	37	50	80
+14596	PF14745	WASH-7_N		WASH complex subunit 7, N-terminal	Coggill P	pcc	Jackhmmer:Q2M389	Family	This family is the conserved N-terminal region of proteins that form subunit 7 of the WASH complex [1]. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes [2].	25.00	25.00	32.80	27.90	24.30	23.70	hmmbuild  -o /dev/null HMM SEED	567	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.86	0.70	-6.33	14	161	2012-03-26 12:44:04	2012-03-26 13:44:04	1	8	111	0	105	164	3	456.10	29	49.95	NEW	GpFhp-asppLpplccsl..s.so..lsps.....hshth-PlsLphhsh......EphslhcL.l.......co-.pKlhNKllsslAuLCsph+pLpccAc.pah.sLlhaGEt.hs..........-st.s........tcs.hphuphlshhpcL.talpRshsllpslhpQluAlhs......h.hshspVHh.sVa-sls-LLshLlolDElhptposlsspWsLY++hl+olppssupa..s.ls.c.cLptL-+hLtcl-spLLsGsIFpphlpphhD...t.hsVscNsths.pEhst.l+plhsplEu+...s-.pp.h...pppcphltlsuLhVlhapLatp.....hD+KLhKplh-lt++hstlslssNllWhPssFLhp+hssh.h..Kthscts.p.shp..+pphLpphstsht+pspphthQlutWhlcMposhsps.....h.hctLpspspLllpGlhhAtplSpllcsllNLHsuLstPhoKosVhslC+llEhLKsIptTFappphhlschlspllQalshhhhphLpssK++lst....DppYocc+LDlLSuLpLupcsLpGssTp-RlhllpLuLushhph..csl+s.......-chcplp.lhp+Lctlu-lppplptts...DsS	.....................................................................................................................................................ssltl.hhs...................cp.s.l.pl..l........................ppc..splhsKllsshusLstEhptLp.pApp........phh.s..Lhh.aG-t....hp......................................................-st....p.......tcs.hphu+hlshLpcl.talpRshp...Vlh...sllpQLuula.s.....t................t..h..........t.hp...t..........l+hp.shac..plucLLthllslDEllppp.slpstaphY+.+h.lpplppssspa.........s.ht..pccl.c.hcphlhpl.....c..tpllss.lhp.tslpp.a-....................h............lpp...sphhspchtt.lcphhspl-sph...spspp.h................pp+pphlslsuLhslh.hplahs..............................h-p+hh........Kplhchp.p+.hPhltlh..uplhahPstFlhpph..Ps...h...+.h..h.s.ppt.t....sht................pp...t...hhppt.stp.h....p.....phpphhh.lssWh.hc..Mpohhstp................th.tp..l....pptsplhl..p.GhhhA.plpphltshh......sL.....ahs....hp...tPhopssVpsls+hlphLKslppha..hp+th.hl..spshshlhQplph.h.p.ltsh....+pplht........ppp.sp.pp......h.-.....hL...uulhls.phl.p..us...o..hp+hhhlpLslshh.hp.....p......hhpt.....................pch..h..hhtplphlsp.htt.h....s...................................................................................	0	40	49	81
+14597	PF14746	WASH-7_C		WASH complex subunit 7, C-terminal	Coggill P	pcc	Jackhmmer:Q2M389	Family	This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex [1]. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organises actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament.  WASH thus effectively nucleates actin on endosomes [2]. The C-terminus is predicted to include a transmembrane region.	25.00	25.00	50.50	25.70	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.87	0.71	-4.66	22	137	2012-03-26 13:08:12	2012-03-26 14:08:12	1	9	112	\N	97	142	2	166.40	44	15.89	NEW	ThpAucpLDsllpsLtc.sao-Go-YF+hLlssFu.phRs...s+NtHL+NFYlIlPsLTlNaV-ahlpsK-KlhKKsKs....susF.TDDGFAhGlAYILKLLcQhppFDSLHWFpolcp+app-ppplp..............pp.ttp.psp...........tD.....-+h.pshp....LTh++lpshpcEasLLhhohoSARIFFc	....................................................ThpAu+pLDsVlushsc.s.uE.Go-YFKhLV-.....VFuschRs.............s+NhHL+NFYlIVPPLTlNaVEaplssKEKLtK....KNKh....uusF..TDDGFAhGlAYILKLLDQappFDSLHWFpSV+p+YtpEhcslt................cp.pspssp.....................pD.....-chhpThp....LTt++Lcsh.p.EapLLhhoLoSARIFFc................................................	0	36	48	74
+14598	PF14747	DUF4473		Domain of unknown function (DUF4473)	Coggill P	pcc	Pfam-B_8489 (release 26.0)	Family	This short family is largely confined to Caenorhabditis proteins. The function is not known. There are two well-conserved aspartate residues.	25.90	25.90	27.20	26.70	25.10	22.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.60	0.72	-3.76	42	147	2012-03-26 13:48:54	2012-03-26 14:48:54	1	3	5	0	145	125	0	80.40	28	75.08	NEW	ushs.s.....s--h+uELhuAGlSppussGlhplspcatsph.hh...pssccsscphhpchps-scsalco.StpD.QpsYpsalc.c+	................s....t-ch+AELhuAGlSpsuscGlhplupcapsphsts...psspcuucphhsphps-scsalKo.oppD.QstYpsalc.Khp.................	0	21	42	145
+14599	PF14748	P5CR_dimer		Pyrroline-5-carboxylate reductase dimerisation	Eberhardt R	re3	CATH:2ahr_A_02	Domain	Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (Pfam:PF03807) and a C-terminal dimerisation domain. This is the dimerisation domain [1].	25.00	25.00	25.60	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-10.17	0.72	-4.04	862	5462	2012-03-26 14:57:42	2012-03-26 15:57:42	1	17	4352	40	1427	4011	1723	105.90	36	39.32	NEW	hsEp.hDulTAlSGSGPAYlahhlEAhscuulp..hGLscchAtpLutQTlhGuAph...lh.............................p.....................pPu......pL+cp.VoSP...GGTThsulpsL..Ecs..u.lcsslhcAlpA..AspRupEL	...............................................sEphhcslTuloGSuP............AYl..a.hhlEAh.s-..A.uVp..hG.ls............+.ppAhclssQsl..hG.uAphlh...........po.sp.......................cPu.........pL+-p.VsS.P...GGTThtulpsL..Epp...u.hcsslhcAlpu..uhp+upch......................	0	448	860	1182
+14600	PF14749	Acyl-CoA_ox_N		Acyl-coenzyme A oxidase N-terminal	Eberhardt R	re3	CATH:2ddh_A_01	Domain	Acyl-coenzyme A oxidase consists of three domains. An N-terminal alpha-helical domain, a beta sheet domain (Pfam:PF02770) and a C-terminal catalytic domain (Pfam:PF01756). This entry represents the N-terminal alpha-helical domain [1].	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.53	0.71	-3.83	150	617	2012-10-02 12:47:07	2012-03-27 09:42:00	1	15	250	8	432	619	22	114.30	24	17.60	NEW	sscclsthltGuccp...hcc++....clpphlt...p-P...apc..pshhahoRpEpacpulcKutthhphhpp.hth............s.p-.................hhhh....tshhspstPhs..LHhsM..FlP....slpsQuosEQpccWLshApphcIl	...................................................................scphsthltGutpp...hchpc....cl..phlt...p-P...hpp..tsh..h..ho+p-phctulcKstphhphhp.p.hth...........s.p-...............................................hhhh....hshhst..shshs....lHhuM..Fls....slpsQGTsEQhpcWl.hu.phpIh.....................	0	160	230	355
+14601	PF14750	INTS2		Integrator complex subunit 2	Eberhardt R	re3	Jackhmmer:Q9H0H0	Family	This family of proteins are subunits of the integrator complex involved in snRNA transcription and processing [1].	25.00	25.00	36.40	27.30	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	1049	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.73	0.70	-13.76	0.70	-7.04	13	186	2012-03-27 12:41:57	2012-03-27 13:41:57	1	7	101	0	136	185	1	667.70	34	87.28	NEW	lspLuphscpEIRPlLPCLVRMSLhSPLDpopchs-sRKplLplLsGlElVNSI.VuLLSlDFHtLEsDlKKEQQlRpKlGhtpp-SlhhpuLps.ulsLEFERS-ssR+lRlVLSELLtlhuQlp-..........pss-..hh+sS.....-LFDs-lYLEEluDllCIAlAELPuLLsIp-lsEsLL+lcNGsplIChlVANhPDsFcEVCpuLIsNG-p.DE-sssG+hRhssLptLspMNPoQALthRupsVEhC+MPuLAltLoL-ps......p.........uDLVAFlSGLLLGsDpplRoWFAhFIRsuQKR+s-....ALphLRccLLcplpslhsp......................uh..putLs-ppVVpuuuLLRLYCALRGIAGlKFs--EsssLlQLlTS+PPPosAGlRFVoLGLCMLlACPSLI.....uspEhEppslcWlpWLl+EEAYFEssSG.........soASFGEMLLLhAIHFHSNQLSuIs-LVCSTLGMKlslRPsoloRhKplFTQEIFTEQ...VVsuHAV+VPVTssLsAslsGFLPlHCIaQLLKSRAFuKH+VPIKsWIY+QICsSVoPLHPlLPuLlEV..YVNSlls..Pss+s..p..........ppsNcPlSEpEIppVFps.....................s..pp..ph.pp................................pssLTsQLLlLYYLLLYEDsRLsNhpshlsts+p...hKsYSscFhScLPIKYLlppAp+cQpcYuuLFSPLLRLLATHaPHLslVDDWLc-Etlssp...ps.....thpss..tssloppslscAFsplpspPsp.sh+llcpLhphsspsLhPaAphllpahphlLscslPRhlpc.hhpplWhRLNoVhPRpLWVhTlNA..Lhspt......p..sLTp-slslDPLpVLRCDcRVFRCsPlhsIlLRlLpuhLAASRopLupHlp-p....Phsp.....hupts.s-s-REEL+hALlAAQESAAVQILLEsCLcTc-D+s................................pssphhtLREl+ullCSaLHQhFIADPsLAKLVHFQGYPpELLPloVpGIPSMHICLDFIPELLuQs...cl-KQlFAIsLsSHLulQYuLPKSLslu+LslNsLsTLLuVLsospRhpLFpslLPuLVRhscAFPPLs-DslslLhQlGRlstSQuuL	..............................................................................................................................................................................................................................................................................................................................................................................................................................hh..............................................................h.h........h...h.h............................................................h...t.lh..t....................t......p..............hlh.l.ph....s...h..h.h.....p.ht.s.h.hh.lthph..................hl.hhpshlh........................................h..........................................................................................................................................hh.hhssh.....hp............hht.........p.............th..h.hshlhs.....h..h..........................pt........hhphh.pt................................shtphhlhhthhhhstphttl..hhpthlt..hc......................t.h..ht.hh.h..pthh.p.....ls..s..ph.sss..t...hs....s.t........................hshh.....sl.tL.....ptp.a...pht..h..ht.hh...ph...t....Php...h..llp...hht..h.................................................................................................................................................................................................................hhhhhahh....ht..h...t...........................................................a.....th.....hshp.hh...hpt......th...lh..hh...hh...hs...........h.....................................................................................p.................................hh.................h............h.......ha..h..h...............................................hs.......P....h..t....h..p....hh.hhl.hl.........p..................h..t.........................................................p.lt.shh..p.s.hhphLl-hh.................................................................thpt.hs..lHphals............lh+llhaQ...................ths.t.l...st.lPuhh.h...l.ph.......p....hhsl..hhs.l...pa..l.pshths.p..hh................phh..hh..t..h............................h.h....hh.sh..h...a..h.....................h.................................................................................................	0	65	79	112
+14602	PF14751	DUF4474		Domain of unknown function (DUF4474)	Godzik A	adam	Jackhmmer:JCSG target SP18061A	Domain	Domain found on N-termina of few families of uncharacterized  Clostridia proteins. Typically followed by a proline-rich domain  or other kinds of repeats	21.10	21.10	25.70	24.10	17.30	16.20	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.65	0.70	-5.19	12	51	2012-04-03 19:57:09	2012-04-03 20:57:09	1	9	45	0	8	47	1	222.40	33	41.00	NEW	LNphhc.sGauY-hppDlFYSthcAWQRchGYs+LYDEAAshhsMlhDCEPlaFsYsGKpWLIEhWKGQYGlsTGuElGVYpss+..ls.s.ha+sTFYcslpDc-hlslShsLh+ssKslaph.pshHWWLTGFpLGpFSpPppLhh-hoITh.DppMppAFlcuLhch.G.Yp.pcEhhlpsNoVplpascP+osQPhs+sphs-shlQhpN+h.CpLYphh..T+sasps..hD+lthlpthhP-la	.........lst.ht.hGas.Y-..ppDlFaSp..h-sWQ....RchGYscLYDcAusshuMlhDs-PlhFsYssKcWhIphWKGQY.s......l..sTGuElGlYpssc.s..l.......s...hhpssaYpsh......pD.s-hh..hohsLcK.s..G.+.......s...l.a...p...............p.......pstHWWLTGFp.....hG.c.F..Spsp-LshshsIsht.c.t...MhpAFlcuLhph.G.Yp.pp-h.h.tppV.hhhs.spp..t..hhps.h.cthlQhhNp..CthYp.h..Tt.h.ph...-+l.hl...hP.ha.......................................................	0	4	8	8
+14603	PF14752	RBP_receptor		Retinol binding protein receptor	Eberhardt R	re3	Jackhmmer:Q9BX79	Family	Proteins in this family function as retinol binding protein receptors [1].	25.00	25.00	26.70	25.20	20.90	22.50	hmmbuild  -o /dev/null HMM SEED	617	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.21	0.70	-13.14	0.70	-6.20	10	202	2012-04-10 09:35:04	2012-04-10 10:35:04	1	7	52	0	108	188	1	404.80	30	72.30	NEW	sssC..csoVs.sLaptChAslSllllLlLuhLsRRcphpsc.....sh+GRhGLlsPlDFLustssRhshuAsFGAlhsslshL.LhoEshhPht....sPoh......s+uhh....hlluhl.hushYYPlhAChost.a.hlutlLGhhhShsahsVpVaQplpCP..........pusplh+YhoLls.lPhLLCLuFLslpashllV+Sl+s.+tG...susp.....slp.sSa.ccYl+s...LLp+p.Lpp.t...tsc.phhSWhpsh.p.pIYsP-PsF+FPh+hlhoslLohluLYphALl.lsullsTlcclRsslsssls.aLLsuhsllhSp......sppclltpVKcaLaulEssalsollLusLlolshLh+sLVsaRppLKtLaRGsph.Lsspa+oPpPoppulsshMpaSuaQsAFlhhGhLIQpllFFLsslslsahlVlPllHGcsLhLL+uLs.hh.shalslllsllLQslhAphhFLps......+ptshsLsNRRuhashoYFLFhhNVLlGlhsulWRlLlSuLhsshhluRlDhSlLppshEohDPGYpoYhGhL+lEsupSHPVhluFCpLLLpupp..pcs..t....psol+.s..cpuhQhlpp.ccspupGuss.uuRuRsRWhLhYTLLpNPsLlshRKst	..........................................................................h.......................................................th..Phshht.........h..hhhhhhh.sthh.h....s.t...sh..................................h....hhhh.hh.h...s.h..hhPhhhChs.....hu.hhG..hsh.hh.h.hh.h....C..........................t....h....h......h..h..hhsh....hhl.h.a.h.............h....t.......t.....................................................h.t.....h........................................................................F.hs.phh.s.....hh....hh.hh...h...............................................................................................s.....hh.shh.s..h.h.h.hp.hh...ha.Rtph.thhtGt...h.....t.t....shhshhtasuaphA..hhhh..Ghhl.phh....lhh.hhhhh................l...h.hPhh.t....p..h.....hh.p....l...h....hh........hhhhhhh...lQ.hhuthhFlp........tt..tlsNR...+sha.h...sahlF.hNVllGhhssh..RllhoslhshhhluphDholh..thtsh.D.Ga.sahshLhh-h.popPshhsFCtlLlpstt.....t.................................h................................h.+W.lh.tLhpN..l.....................................................	0	55	60	74
+14604	PF14753	DUF4475		Domain of unknown function (DUF4475)	Eberhardt R	re3	Jackhmmer:A4D161	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.	25.00	25.00	25.20	25.00	20.90	24.30	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.79	0.71	-11.80	0.71	-4.80	11	195	2012-04-10 10:52:20	2012-04-10 11:52:20	1	2	81	0	110	177	3	126.00	34	61.63	NEW	Yp+IVG-.DDGG+LFo.cEYEcYKKpVhPhRlKNRlasSWpsssGhDCKlIGPEThCFCsHR.aKpHcTDhpp.lspcRPhtlPC+sstCpC+saaYlPhpGSpslRCp.CKHhss-Hss..hsa+Cs+ss....pCsG.FcSsaoCuCGpss.cHpTllE....T+-ERhupGKPVup.D.......VPYtuMG.GlTGFSSLs-Gh.R....lDsSGhGsss	.................................................................................................................stohCFCsHh.h+pHph.........p.....tlsCp.ttCtC..a.alP....................s..h+C+.C+H.hppHss.....shh.Cp.t.ss....tCss.FpSsah.C.s.Csp.h.tH.T.hhE....Tcp..h.t.t.....................................................t...........................	0	42	49	67
+14605	PF14754	IFR3_antag	PPRSV-IRF3_ant;	Papain-like auto-proteinase	Coggill P	pcc	Pfam-B_8065 (release 26.0)	Domain	The replicase polyproteins of the Nidoviruses such as, porcine arterivirus PRRSV, equine arterivirus EAV, human coronavirus 229E, and severe acute respiratory syndrome coronavirus (SARS-CoV), are predicted to be cleaved into 14 non-structural proteins (nsps) by the nsp4 main proteinase Pfam:PF05579 and three accessory proteinases residing in nsp1-alpha, nsp1-beta and nsp2. This family is the two nsp1 proteins that together act in a papain-like way to separate off the rest of the various functional domains of the polyprotein. Once inside the host cell, this nsp1 interferes with the regulation of interferon, thereby enabling the virus to replicate.	25.00	25.00	573.10	572.10	19.50	18.40	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.71	0.70	-5.38	2	79	2012-04-10 11:02:07	2012-04-10 12:02:07	1	4	2	0	0	81	0	249.00	97	12.89	NEW	MATFSATGFGGSFVRDWSLDLPsACEHGAGLCCEVDGSsLCAECFRGCEGVEQCPGLFMGLLKLASPsPVGHKFLIGWYRAAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFISTDHASAKRFPGARFALTsVYAusWlsSPAANSLlVTlDQEQDGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGlNAsSGGLKFHIMRuSPQRAWHITTRSCKLKSYYVCDISEA	MATFSATGFGGSFVRDWSLDLPAACEHGAGLCCEVDGSTLCAECFRGCEGVEQCPGLFMGLLKLASPVPVGHKFLIGWYRAAKVTGRYNFLELLQHPAFAQLRVVDARLAIEEASVFhSTDHASAKRFPGARFALTPVYAssWVsSPAANSLIVTlDQEQDGFCWLKLLPPDRREAGLRLYYNHYREQRTGWLSKTGLRLWLGDLGLGINASSGsLKFHIMRSSPQRAWHITTRSCKLKSYYVCDISEA	0	0	0	0
+14606	PF14755	ER-remodelling		Intracellular membrane remodeller 	Coggill P	pcc	Pfam-B_2813 (release 26.0)	Domain	This domain represents subunit nsp3 of the RNA-arteriviruses, such as porcine arterivirus PRRSV and equine arterivirus EAV, and is a tetraspanning transmembrane protein that contains a cluster of four highly conserved cysteine residues. These are predicted to reside in the first luminal domain of the protein. Arterivirus nsp3 proteins are uniformly predicted to contain four transmembrane helices, with the N and C termini of the protein residing in the cytoplasm. NSP3 are localised to the ER and appear to be essential for formation of double-membrane vesicles that originate from the ER during the life-cycle of the virus.	20.50	20.50	20.50	20.50	20.40	20.40	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-11.03	0.71	-4.13	5	141	2012-04-10 13:33:59	2012-04-10 14:33:59	1	8	7	0	2	101	1	140.80	66	10.05	NEW	GPPPAPVSASVLDHILEAATFGNVRVVATEEQQRPVPAPRsRPSAoSS.GDVKDPAsVPPVPKPRTKLAKPSPTQAPTPAPRTRhQuA.....SsQEPPsGsusAPASAPKWRVAKTVYSSAERlRTELVQRARSlGDVLVQALPLKTPAVQRY	..................................GPPPAPVSASVLDHILEAATFGNVRVVsTEEQQRPVPAPRsR+SsoPP.GD.V.KDsAsVP.PVPKPRTKLAKPSPsQAPTPAPRTpPQsA.....Pp.EPssuTAAAPuSAP+WRVAKTVYSSAERhRTELlHRApSlGDoLVQALPLKAPAVQRY............................................	0	0	1	1
+14607	PF14756	Pdase_C33_assoc		Peptidase_C33-associated domain	Coggill P	pcc	Pfam-B_535 (release 26.0)	Domain	The nsps or non-structural protein subunits of the arteriviral polyproteins such as porcine arterivirus PRRSV and equine arterivirus EAV are auto-cleaved into functional units. the function of this particular domain is not known.	25.00	25.00	27.10	25.60	21.90	18.30	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.16	0.71	-4.48	4	550	2012-04-10 15:06:29	2012-04-10 16:06:29	1	10	6	0	0	558	0	108.70	91	8.18	NEW	sSPDAVEVSGFDPACLDRLAtVMHLPSSsIPAALAEhSGDssRPsSPsTTVWTVSQFaARHpGG-HPDQVCLGKIISLCQVIE-CCCSQNKTNRsTPEEVAsKIDQYLpGAsSLEECLA+LE+ARPPSshDTSFDWsVVLPGVEAAs	...SPDAVEloGFDPACLDRLAcVMHLPSSsIPAALAEhSsDss.RssSPssTsWTVSQFaARHtGGsH.DQVpLGKIISLCQVIE-CCCpQNKTNRsTPEEVAAKID.YLRGATsLEECLAKLERVSPPSAADTSFDWNVVLPGVEAAN.	0	0	0	0
+14608	PF14757	NSP2-B_epitope		Immunogenic region of nsp2 protein of arterivirus polyprotein	Coggill P	pcc	Pfam-B_58 (release 26.0)	Domain	This domain is in a non-essential part of the nsp2 (non-structural protein) subunit section of the arterivirus polyprotein. This domain carries seven small sequence-regions that are predicted to be potential B-cell epitopes.	25.00	25.00	42.60	27.50	20.90	24.90	hmmbuild  -o /dev/null HMM SEED	272	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-11.77	0.70	-4.92	22	1615	2012-04-10 16:54:06	2012-04-10 17:54:06	1	14	11	0	0	1542	0	119.20	49	22.05	NEW	VKsYPRWTPPPPPPRVQPR+TKsVKSLPEsKPVPAPRRKVRSDCGSPlLMGDNVPsuhEDLsVGGPLshPTPSEPhTPhSEPsLsPu.Q+ls+PsTPLStsAPVPAPRRTVSRPhTPLSEPIFVSAPRHKFQQVEcAN.AusTLTpQDEPLDLSASSQTEYEAsPLAP.QNhGlLEsGGQEAEEVLSEISDlLNDhNPAPVSSSSSLSSV+ITRPKYSAQAIIDSGGPCSGHLQ+EKEACLSIMREACDAoKLuDPATQEWLSRMWDRVDML	................................................................................................................................................................................................................................................................................................................................................................	0	0	0	0
+14609	PF14758	NSP2_assoc		Non-essential region of nsp2 of arterivirus polyprotein 	Coggill P	pcc	Pfam-B_6704 (release 26.0) 	Domain	This non-essential region of the nsp2 subunit of the arterivirus polyprotein of such as porcine arterivirus PRRSV and equine arterivirus EAV may offer immunogneic surfaces to B-cells. It is associated with Peptidase_C33, Pfam:PF05412.	25.00	25.00	29.10	145.00	21.80	19.00	hmmbuild  -o /dev/null HMM SEED	203	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.45	0.71	-4.19	18	61	2012-04-10 17:03:01	2012-04-10 18:03:01	1	4	4	0	0	61	0	167.70	66	15.20	NEW	KtFEtsAsEEVQEuGHKAVHSALLAEGPNsEQVQVVAGEQLcLGGCGLAlGsAp.................SssDSMKENMhNShEDEPLDLSpPAPAuTTTLV+EQTPDNPGSDAGALPVTVRcFVPTGPhLRHVEHCGTESGDSSSPLDLSsAQTLDQPLNLSLAAWPVKATASDPGWVHGRREPVFVKPRcAFSDGDSsLQF	................................EEVQESGaKsVHSA.hAcGPNcEQVQVVsGEQLKLGGCsLsVGNA+tss.sSuu.h...................shtsEPLDLSpPAsAATTT..tEpTP-NPGsDAGALPVTsRcFVssGshL+HVEHCGTESGDuSSPLDLSDAQs.DQPLsLSLssWPV+sTASDPGWVhGtpEsVFlKPRtshSDG-SshQh	0	0	0	0
+14610	PF14759	Reductase_C		Reductase C-terminal	Eberhardt R	re3	CATH:2gqw_A_03	Domain	This domain occurs at the C-terminus of various reductase enzymes, including putidaredoxin reductase, ferredoxin reductase, 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin--NAD(+) reductase component, benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit, rhodocoxin reductase, biphenyl dioxygenase system ferredoxin--NAD(+) reductase component, rubredoxin-NAD(+) reductase and toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component. In putidaredoxin reductase this domain is involved in dimerisation [1]. In the FAD-containing NADH-ferredoxin reductase (BphA4) it is responsible for interaction with the Rieske-type [2Fe-2S] ferredoxin (BphA3) [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.31	0.72	-9.77	0.72	-3.69	153	1813	2012-04-11 08:06:00	2012-04-11 09:06:00	1	26	1065	20	581	1646	395	82.00	28	19.73	NEW	WFWSDQa-h+LQhAGl......ssutDp...sVlRGs.ss.t...t..sFol.a.....ah.+supLlAlculNp....sp-ahhu++Llsput.ssssstLA...DsussLKsll	..........aFWSDQYs.hplQhsGh.......s..p..u.h..Dc......h.l.lRGs..ss...p..........p.....phhs.a........ah..psu.....pllussulNp.......s.c.p.h....t.hs.+.chltsut..sh..s..s...t...lh.c.t..L.................................	0	153	355	470
+14611	PF14760	Rnk_N		Rnk N-terminus	Eberhardt R	re3	CATH:2pn0_A_01	Domain	This domain occurs at the N-terminus of Rnk, an RNA polymerase-interacting protein of the GreA/GreB family (Pfam:PF01272). It has a coiled coil structure [1].	23.00	23.00	23.00	23.10	22.90	22.60	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.40	0.72	-7.89	0.72	-3.88	110	932	2012-04-11 13:03:29	2012-04-11 14:03:29	1	4	909	6	162	424	20	41.70	54	29.57	NEW	pPsIhlophDhcRL-pLl-.....shstps.sstptLpsEL-RAclV	....+PoIIIs-LDsERl-tLLE......psAhushPlA-ALsAELDRAph....	0	32	73	117
+14612	PF14761	HPS3_N		Hermansky-Pudlak syndrome 3	Coggill P	pcc	Jackhmmer:Q969F9	Domain	This domain is at the N-terminus of these vertebrate proteins. This region carries the clathrin-binding motif LLDFE at residues 172-176 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072 [1].	25.00	25.00	26.30	25.30	23.80	24.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.64	0.70	-4.94	10	92	2012-04-11 15:52:16	2012-04-11 16:52:16	1	4	66	0	50	89	0	187.50	42	18.61	NEW	RlhssHsFsSQcVssscp.EPsthCsu...GtDtLFlu..suuCpVEVasls.pppspshssFuTlupVlplsYScsGDYlVTIEcKspso.............alRsYlNWcsp..pscsstVslRhsGhphpssps-ss.pcQhEllElPL.scsPhCIuCCsloGsLLVGssspLllF.pLKspsl....scchphlDF-cpLI.hhsuasPscluhCssYIAlho-LEVhllKLsp	................plhshHsFtuQpls.sp...EPt.hCsu...G.-tLFl...suuCc..VEsaslt...pEhsp.+ssFuTl.GcVl.plsYo-u.GDYLlslEcKspso............................FlRsYsN.WRpt...................psppshVsl..Rhh.....G....hpsshspsh...cpphpllEhPL.scsPhsluCCsspGsLLVusps+llLapLphphh.........spchuhlDFE.pplhhhh.shsPhcluhCssalAlho-hElllhKLp.s................	0	11	15	30
+14613	PF14762	HPS3_Mid		Hermansky-Pudlak syndrome 3, middle region	Coggill P	pcc	Jackhmmer:Q969F9	Domain	This domain is downstream of the N-terminus of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and one of two di-leucine sorting boxes at residues 542-548 well as a peroxisomal matrix targetting motif at residues 614-623 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072 [1].	25.00	25.00	34.40	34.00	17.70	24.20	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.10	0.70	-5.86	9	100	2012-04-11 16:43:41	2012-04-11 17:43:41	1	6	68	0	54	97	0	358.40	41	36.33	NEW	ptpPhElLG.csp.ssls...lslc.oTslss-hppthpV.............ppLLaRRFsPchpshhhs-ph..+LHSLQLhPhYpps...................thtss.ppsspppcLhulhCFFShPppGYLYslspu......ssLlS...sYtYspcsppsVLsspFLHsITpsuLpsaTlRsSssss.cpsshlDshhcsCPshohcVChltlp.FIGLpslsphcsallLLops-spph.ph.......................ttsuWsLYhl.sssohhQLYp-hl-huppYcsspspohhHLLuEAHLLlRsAL..hchs.tcsscKpEL..............hpAapESCuhLGDhaSR.-.spchcLALPYY+MSGLphs-llpR..h.ht........shppuh.sRGhIaaLpHuL......hcchsEpLScphAspVlphFthu-PcpL	................................................................................t..Ehlup.sppsuhs...lhlE.sTuhts-tht.hpl.............ppLLa+RFs.PDhsph.s..s.--h......+LHSLQ..LhPIYQpu...........................................thpsctps.o.p..c+chlul..FCFFShPcsGYLY.lsps.......VcLhS...sYpYs-+spQAVLospFLHVITS.........ssLQsaTVRCSAssA+cc...DsY..hDTT...hKuCPPVSh-VCsLRlQlFIGL+slCph+sHllLLTKAss.Esh.cRpps.hphhph......................................t.tssp.t.sssspsuWsLYll.sshsshpLYc-hl-YupoY.+os..po..po..hhHLLuEAHLLlRuAL......h-ssphc...s....s.c+t...EL............................................................hcAF+-SCu+LGDpa....SR.........hs..ppp..cL..AlPYYKMSuLshs-V....lsR.hthshp...........st.pph....tcGLlaYlp+sL.........hcphspp...L...scphu..s..cllpha.ht-Ppp..............................	0	16	19	34
+14614	PF14763	HPS3_C		Hermansky-Pudlak syndrome 3, C-terminal	Coggill P	pcc	Jackhmmer:Q969F9	Domain	This domain is downstream of the mid domain family, Pfam:PF14762, of these vertebrate proteins. This region carries a number of tyrosine sorting motifs and the second of two di-leucine sorting boxes at residues 711-717 well as the ER membrane-retention signal KKPL at residues 1000-1003 in SwissProt:Q969F9. There is also reference to a human Mendelian disease at MIM:614072 [1].	25.00	25.00	27.90	27.50	22.30	20.70	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.17	0.70	-5.46	4	71	2012-04-12 10:25:22	2012-04-12 11:25:22	1	4	47	0	35	70	0	308.80	58	33.88	NEW	MKNlsPLpAlpYLRKL-s..hsSVLVTLTKAsMALKMGDLDMa+NEMpSHSEMhLlCGFlhEPRLLhpp+cGpllPTEhAlaLK-sQPGLLVASlluLpcNsKIslEEAD.FFKsLCsK..DEDsVPQLLVDFWEAhLVAC.P-sVLpELhFKLTSQYVWRlSK+phP-ThPL+TsEDLINoCSHaGLI.PWVshlMSs-ShhsKshsEDl.KLQSllsGPShDltshLPaLEsLu-ssNsGLolH.lLChTRLtpYEcsIDpLLc+hPEAVl.YApHELKE-spslWWpKLLPELCpRl+pstschplalSSLKETLSVVAsEL-LRDFLNlLPEDGTAAFFLPYLLaCS+KK.Ls	.............MKNlsPLsAhpYLcKL-ssGhsSlLlTLTKAAhALKMGDLcha+sEMcpHuEMpLVhGFILEPRLLlQQ....+KG....QllPTELAhaLK-TQPGLLVASlLGLQKNsKIulEEADuFFKV....L.CuK..DEDslPQ......LLVDFWEApLVAslP-lVLQELhFKLsSQYlWRLSc.........+....ps....P.DT....hPLRTuEDLINuCSHYGLlhPWVplLhSs-ShsDKsasEDL.K.LQSLlCGPShDlASIlPFLEPLS.ED.ThA..G.LSlH.lLCpTRLpEYEpsIDpLL-RCPEAVIsYANHELKE-.scsLWWK..KLLPELCpRl.+...s.....G...GE+.p...LaL...SuLKE..TLSllAsEL-L+DFlNlLPEDGTAAFFLPYLLaCSpKK.l.................	0	5	7	18
+14615	PF14764	SPG48		AP-5 complex subunit, vesicle trafficking	Coggill P	pcc	Jackhmmer:O43299	Family	This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments [2]. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs [1].	25.00	25.00	26.50	25.30	21.30	22.00	hmmbuild  -o /dev/null HMM SEED	460	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.64	0.70	-12.59	0.70	-6.00	14	140	2012-04-12 10:55:25	2012-04-12 11:55:25	1	4	79	0	89	136	0	309.70	30	54.76	NEW	-LQcACLlEuVtlLchlC+p....DsS..hlhRshPpl+pLasRls......ussu.......pu....psLLsIhQFFLsHGEs.sshDu-ushcphFspl.ucpFpcPhLAa-hlpFhhpNp.plLssp.sslhpp.FPsLLK...........hLAWsu.sLhscFVtlLPsLlsssTAlElLHslLDLPCLoAAL-hphRuus......su..tpslhs.p........................scssush-uhpsPhtcsLFpalLRsEuu..ssh.-R...Lss.LHplLtshussP...RVhQCupslPsLLclaFsslhcpAsssLlspLl.lLLERsstLa.lpsapt-V++VLSptlLtLsph+PsLlV-Lp+-lL-FlG.ospsh.pu+p-hasallWAlGEYhSsuhD+RCos-hhspaFEsLEs.lLaElopop.............ssushspsssRllssLMTsLsKLAoRsp-LlP.RV...uLhLoKhpo...psh.t.s.s-ps..sttlhpRAs-LlsLLKhPuVAthVLs..Posss	............................................hhpsl.hh..hsp.....ssp..hlh+shshhptlhtRh.......ss.s........s....hhlLslhpFaLsa.u-h..shhDs-s.ht.hhtt..h.s..a.s.hhs.thhthh..p....h........h...hP.lh+...........hlA.ps..h.t.h..lhP..hhsstohh.hh..lhDLPhlshsh...........................................................................................................s.ts.......hpsha..lL+scss...s.htp.........s.h.thht.h.t.s...............RhhtshphsP.lLphaFsssh.p.s...st................sLhs.tLh.hlhtR.s.ha....aphp.......lpphh.p.hh.hhphpPthlh...tp.l.t....t........tt.hh.plsWhlGEa.us..........t.h.thaEsLEh.hhac..................................................................phhh.lhsshsKlAsh..-h.s.+s....l..........................................................s.....................................	0	26	52	67
+14616	PF14765	PS-DH		Polyketide synthase dehydratase	Coggill P	pcc	Pfam-B_852 (release 26.0)	Domain	This is the dehydratase domain of polyketide synthases [1]. Structural analysis shows these DH domains are double hotdogs in which the active site contains a histidine from the N-terminal hotdog and an aspartate from the C-terminal hotdog. Studies have uncovered that a substrate tunnel formed between the DH domains may be essential for loading substrates and unloading products [2].	27.00	27.00	27.10	27.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.91	0.70	-5.26	177	5569	2012-10-02 20:54:35	2012-04-12 14:52:00	1	1171	1046	21	2255	5792	232	275.10	19	12.09	NEW	HPLL.G.tplths..sssphhapspLs.hps.PaLsDHtl.tGpsllPGsualEhAhpAuppht.....tt........shtlc..-lslppsll.ls.pss....shplplslpss.stst..............phplhSpsssst...............WshHspGplt.......................sh..h..tpt..s.s...ls...stthYpph...t.phG.ltY.GPsFps.lc.plhp.............s..p.shApltls....pshtttt.........ahL.HPulLDuslp.sh..................tt.ttshLPh.ulsplplh........t.....t.hhscsch.....tsts......htsclplhD.ssGpslsplcuLph+tlsstshts	...............................................................................................H.ll....t....s.....t.tth...h..hp.s.p.l.s..hp...p..h..s..a...L.........s.D.H.t...........l.....t...........G...........p............s...........l..hPu...sual-...hAl.p....Au..p..pht..............................................................shplc....-lsh.t.p.sLh...ls.......t............s..........s........s...............hplp..l....s.....lpss...tttt............................p.h..plhopss..sst...........................................hshHupGtlt...htttt................................h......s.................h....t......t.........h...............................t............t....................s......................................ls........................ssp...h...Y..pth............t...phG...h....p.Y..Gs....s..F...pu..lp..phhtt.........................ss..p..shAclt..ls....................psht.t.t.tt....................................ahl...HP...u..........lL......D.ushp..sh....hhhh...............................ttsts..tshlP......h....uh.pplplh..................................ssth.hsh.sph...............................stts....................h.t.s.s...l.p.l..........h.......D....t........s......G.......p........s...l...h...plpulthp.ht.....t........................................................................................................................	0	518	1299	1894
+14617	PF14766	RPA_interact_N		Replication protein A interacting N-terminal	Eberhardt R	re3	Jackhmmer:Q86UA6	Family	This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta [1-2].	24.00	24.00	25.30	24.50	23.60	22.80	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.43	0.72	-7.87	0.72	-4.49	25	123	2012-04-12 14:36:35	2012-04-12 15:36:35	1	4	80	0	63	129	0	41.10	45	19.07	NEW	ss++s.hKt.psPsWK-plRccChcRlRcpRscLLp+hRtss	.............+RshaKh...soP....sWKEsaRpcCl-RhRssRs+LLs+aRps....	0	20	32	47
+14618	PF14767	RPA_interact_M		Replication protein A interacting middle	Eberhardt R	re3	Jackhmmer:Q86UA6	Family	This family of proteins represents the middle domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. This domain is responsible for interaction with RPA [1-2].	25.00	25.00	25.80	26.00	24.10	23.80	hmmbuild  -o /dev/null HMM SEED	83	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.86	0.72	-3.23	27	109	2012-04-12 14:37:26	2012-04-12 15:37:26	1	3	65	0	48	112	0	74.40	36	36.46	NEW	p.hlp-lhp-EhppLppsspsh..................hh..psh.phh......pEh--.Lt.h-.....-lppEhhpp.EhphhtphEpthphE-phLsthlp	............h..lVQEVMEEEWpsLpssps.............................hscshst....pEh.-.LusLE.....EIpQELlpp..Etsl...lp.EaE.cshph--phLs.hl........	0	8	18	31
+14619	PF14768	RPA_interact_C		Replication protein A interacting C-terminal	Eberhardt R	re3	Jackhmmer:Q86UA6	Family	This family of proteins represents the C-terminal domain of replication protein A (RPA) interacting protein.  RPA interacting protein is involved in the import of RPA into the nucleus. The C-terminal domain is a putative zinc finger [1-2].	25.00	25.00	25.70	25.70	24.50	23.60	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.64	0.72	-10.40	0.72	-3.58	50	138	2012-04-12 14:38:09	2012-04-12 15:38:09	1	4	109	0	85	130	0	80.90	31	35.91	NEW	lCPVCppspLpt...spph...lhC.......sC.G.lplspp.............thshc.pLpshLppslspHtpp..C..spsPpFslp..ssss.t....sLhhpCpsCcahpll	......lCPVCpptsLph......sssh......lhC........pC.G.Lplssp................................ttplohp.pLctpLppslscHttp..C..spsPpFslp...........sssp.p....sLhhpCtsCchhsll...................	0	27	41	66
+14620	PF14769	CLAMP		Flagellar C1a complex subunit C1a-32	Coggill P	pcc	Jackhmmer:Q6P047, Pfam-B_2704 (release26.0)	Family	This family represents one small subunit, C1a-32, of the C1a projection (the seventh projection of flagellar) [1]. Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules in flagellar plays a distinct role in regulating eukaryotic ciliary/flagellar motility. The C1a projection is a complex of proteins including PF6, C1a-86, C1a-34, C1a-32, C1a-18, and calmodulin. C1a projection is involved in modulating flagellar beat frequency and this is mediated via the C1a-34, C1a-32, and C1a-18 sub-complex by modulating the activity of both the inner and outer dynein arms [2].	22.70	22.70	22.70	22.80	22.20	20.90	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.32	0.72	-3.86	50	207	2012-04-12 14:49:21	2012-04-12 15:49:21	1	5	87	0	139	195	0	94.30	27	33.37	NEW	hpslhFspp.psaohppsSshhs..lhpplhp..sht...pthshtcshpha+pll.hppulp.+Pshs...htlFohppl+tlh..-ahhpo...aaRHY+LYpasFosphphshpt	......................................................pshhasht.psFoh.phothhs..lhpplhp.sh.........t..t.thslp-shphhppll.hpausp....cs.hs..............htlFshcpltslh..DYhhpo......aa+HaKLYcalFssppchpl..s.........................	0	59	70	89
+14621	PF14770	TMEM18		Transmembrane protein 18	Coggill P	pcc	Jackhmmer:Q96B42	Family	The function of this family is not known, however it is predicted to be a three-pass membrane protein.	26.90	26.90	28.90	28.50	26.00	24.80	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.61	0.71	-4.58	43	161	2012-04-12 16:07:47	2012-04-12 17:07:47	1	4	128	0	104	149	2	117.70	37	69.08	NEW	cshhsFhpulDWp.EPWlluLlsFH.llhllsslhoR+phsh..QhslFhlhlshVahuEplNchuupp...W..+pFupp..pYFDspGlFlSlVaSsPLLl.shllllshlhphsplhlclKptpL+c+t+p	...................s..h.shhhslDWp.EPWLhuLhsFH.llhllhslhoppphsh..Qlh.lFlhhlhhVYhuEhlNchuAtN.W.....+.FSpp..pYF...DspG.hFISlVaSsPLLlsshll............llphlhphsp...lMsclKptpl+c+t+.h...............	0	37	58	81
+14622	PF14771	DUF4476		Domain of unknown function (DUF4476)	Coggill P	pcc	Jackhmmer:Q86XN7	Family	\N	22.50	22.50	22.70	22.80	22.10	22.10	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-10.08	0.72	-3.95	42	221	2012-04-12 16:46:32	2012-04-12 17:46:32	1	12	125	0	88	194	12	93.60	26	26.52	NEW	tspshsshphpplhphlpph.sF-s-+lphlphhtts....p....hosspssp.llphasFsss.+lchLchlhspIhDh...p.stptlhssFs....Fs.ss+p+spcll	.........................h...hhs..phcphhphl+hh.sas-sphchlcshhpp.....hs...hosspssp.llshaoFsc-.+lpslclltspIlDt...p.Nhp.l.chhp....hs.SpKc+h+chl.......................	0	51	59	71
+14623	PF14772	NYD-SP28		Sperm tail	Coggill P	pcc	Jackhmmer:Q96MC2	Family	NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation [1].	22.10	22.10	22.10	22.10	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.16	0.72	-3.94	28	241	2012-04-13 08:02:08	2012-04-13 09:02:08	1	6	113	0	152	239	2	101.00	27	17.72	NEW	+VusDtREtpRRhcEppt+pphpp+LcpEstpshpchppIst+WsplhphphPp-LpcplppQ+ptCpcllppK-plIs-hpp-LcppD-cYlpsl+cQucDl-	.......................t.thcE.pR.Rtc.pp..h.pp.hhcK....Lp.pEtcp.optphscI....spcWcphhcp..tpspELpcplpt.ppphpcllcpKcplIp..........p.L.pp........-Lcpt--pYspsl+pphcslp.......................	0	60	76	113
+14624	PF14773	VIGSSK		Helicase-associated putative binding domain, C-terminal	Coggill P	pcc	Jackhmmer:A4D997, Pfam-B_8865 (release 26.0)	Family	The function of this short, serine-rich C-terminal region is not known. However, as it is frequently found at the very C-terminus of P-loop containing nucleoside triphosphate hydrolases, it might possibly be a binding domain.	19.30	19.30	20.10	19.50	19.00	17.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-8.99	0.72	-4.06	20	116	2012-04-13 08:13:48	2012-04-13 09:13:48	1	6	103	0	91	108	0	58.80	41	6.30	NEW	SQLAAhlp..........tpsptttppppsstsKpDPIQAIL.AuAGVEYTHENSEVIGoSKlEEpLSRRAE	...................................h.................ptths.t.+pDslpuIL...usuGVpYTHpNsEVIGSSKlEppLSRpAt......	0	15	36	60
+14625	PF14774	FAM177		FAM177 family	Eberhardt R	re3	Jackhmmer:Q8N128	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 205 amino acids in length.	25.00	25.00	25.10	25.40	24.20	24.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.45	0.71	-4.20	23	150	2012-04-13 08:18:13	2012-04-13 09:18:13	1	4	89	0	91	148	2	107.10	36	57.19	NEW	tssshppsE.......pcctps..hpsP+RllaFuDG.sMEEhSo-EE..-cp-..ttppsh.hss.lDsscLshGPalhapsh+lusssluuCDalGtplAohhGITss.KYQYtl-EY.Rhpcccpccpp-schs	...............................sp.......-.....t..t...hphP+RlI+FssG.sMEEYSo-E-...pt.p....pps..hss..lDs..scL...sWGPalhahhh+huosolusCDaLGE+lAshhGIosP.KYQYsl-EYhRhppccpccppcpp.......................	0	27	40	66
+14626	PF14775	NYD-SP28_assoc		Sperm tail C-terminal domain	Coggill P	pcc	Jackhmmer:Q96MC2	Domain	NYD-SP28 is expressed in a development-dependent manner, localised in spermatogenic cell cytoplams and human spermatozoa tail.  It is post-translationally modified during sperm capacitation and ultimately contributes to the success of fertilisation [1]. This short region is found at the very C-terminus of family members of family NYD-SP28, Pfam:PF14772.	27.00	27.00	27.60	27.80	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.48	0.72	-8.85	0.72	-4.27	38	177	2012-04-13 09:00:41	2012-04-13 10:00:41	1	6	106	0	122	167	5	57.70	34	9.39	NEW	caWpphupllspcphclWcsLpcuLp+YhclLpcRtpllp-s...ppLcpQNsEL+sLLpQYl	...........taWpths.pshstpp.clWcsLtpuLp+Yp..p..lLppRspLlpEs...psLcpQNpELcpLLpQYl....	0	56	73	100
+14627	PF14776	UNC-79		Cation-channel complex subunit UNC-79	Coggill P	pcc	Jackhmmer:Q9P2D8	Family	This family is a component of a cation-channel complex.	27.00	27.00	32.60	31.50	26.70	22.00	hmmbuild  -o /dev/null HMM SEED	525	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.82	0.70	-6.12	7	116	2012-04-13 09:36:58	2012-04-13 10:36:58	1	3	72	0	67	108	0	431.60	53	21.57	NEW	.p.DssRhuhYPNL-YpsLYsALs.LlDVsPLIQhG.psFGpAlLQCLuCLLPFL-+DlIDsLPYLsASoluVLPspLHp-IlNhLCaYILPFTI..TRpp-.ppEshssQSVouVIMhVhQYosNPuHHCQLLECLMsLKpsVhKDlLsVIAYGTusuRuSAAKLLFYYWPsFsPNlaDRKslhsKhs.shsPFsCQR-tCPNAGNAEAsKVCYDHsISIsausDoPPPLYLCIECANcIHREHss.hFhDILHPMQplShlCENKNCRSp-KpAlSICFSoECASaNGNHPIRYCpQCHsNRHNsRRGuD.....HlsHpuLssshphDuEhQsahVEulVSLL+EAc.hs.psp+-spp.pt.....................tsssssssDshohEERQLLGRYGlWLLVGhCTPs-sTPsElLGRLLuMLFHWFHsTAY.aD..sQs..ESolEKLKs-aVCsWLp-ls+sHacVFISCLLPHPsEYuRVGGHW-T.LsS+ToHLKEGLpRLlCLlPYEVIop-lW-hVMP+WhEAIsNDVPE+ELsELKI	.....................................cstphs.aPsLpYtsLY.sls.LlDlhPhlphu...shupulh.sh....tslh.FL.pp...-.lppLPhhh..Sslu.shPs......LHpsIlphLsh.hLPhsI...op..+pp..s..stss..SsSShl.MhshQ.YosNPsaHCQ.LLECLMphKppVhKDlLhVIAYGsups+ssAsphLFaYWPshpPshh.pchhh..hphT....sasPhpCQ+.cC.NA.hN.t.AsK.hChD.olSlshu...DpPPPLY..LC.ECupcItt.............-Hsph..hh.....DlLhP.t.p..lShlCp.pKNCpSp.....s+pAlshCFSst.........Csuhp........GN+PlRYCppCHoN+HsschGus.................................a.sp.s..sshphssE...sphVEAVl.......SLL+EAc.hstppphEhscpcpht..p.....................hsssshs.s.....cspstc-p+lLupaGIWhLVuLCT.Ps-sTPsEsLuRLluMlFpWFHsTAYhhD.............DpV..GShlEKL.....KspaVsc...............WLKslCcl+acVhl.C.LLP+P.EaARVGGaW-p..sSpsopLKEGLsRllCLlPYsVIo....ppl............W-plMPcWhEAIps-VP-ppLpEh+.t.............................	0	23	27	48
+14628	PF14777	BBIP10		Cilia BBSome complex subunit 10	Coggill P	pcc	Jackhmmer:A8MTZ0, Pfam-B_35417 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. BBIP10 localises to the primary cilium, and is present exclusively in ciliated organisms. It is required for cytoplasmic microtubule polymerisation and acetylation, two functions not shared with any other BBSome subunits. BBIP10 physically interacts with HDAC6. BBSome-bound BBIP10 may therefore function to couple acetylation of axonemal microtubules and ciliary membrane growth [2]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3].	26.00	26.00	26.70	26.20	22.80	21.10	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.27	0.72	-4.60	4	68	2012-04-13 10:27:55	2012-04-13 11:27:55	1	3	62	0	48	71	0	65.60	41	58.35	NEW	MuEs..KsshRE....VLPKQG.L.hEDssshVLCKPKLlPLKSVTLEKLEKMQpEAQ-sVRpQE.ApKpp	.............................t.......ll.Pcp..G.La.hE.-.h.hshVLCKPKLlPLKSlTLEKLEKM..p+cAp...cpl+ppc.spp..t................	0	17	22	39
+14629	PF14778	ODR4-like		Olfactory receptor 4-like	Coggill P	pcc	Jackhmmer:Q5SWX8	Family	In C.elegans, odr-4 and odr-8 are required for localising a subset of odorant GPCRs to the cilia of olfactory neurons [1]. Olfactory receptors (ORs) are synthesised in endoplasmic reticulum of the olfactory neurons, trafficked to the cell surface membrane and transported to the tip of the olfactory cilium, where they bind with odorants. Various accessory proteins are required for proper targetting of different ORs to the cell membrane. ODR-4 was the first accessory protein to be described.	24.50	24.50	24.60	29.60	22.90	24.00	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-12.36	0.70	-5.76	38	177	2012-04-13 12:22:49	2012-04-13 13:22:49	1	5	117	0	110	194	1	313.30	28	78.69	NEW	GLllGp.tssp+..saVlplspTPpc-ssss.................................t..shpslDp-Wls-HAppVoRMLPGGhsVlGlal..ls.scsshcpss.hpthpplls.......................tsphhhhhspchspphhlalshss..p.phsC+shshts..ssuoh+PsDaKht..pt.spWhplpsshsl-hhlPlt..tspsst.shc......cplppslphhscplpsuhsl..lsGchhptp..l...........................................................psh.plplllP..............tpsspppstplpsssuslphpGslps+ualps.+solu-.AhpslKpDIl+SLpoRl-lhhDsLhpspsssss....t................................hppLPRRVhhsl.st..............sl.hsDYLFtsEsspcshtphp-lLshphsspslstshE	............................................GLllGp..sspc..shllhhstTP.p-pttt............................................t.p.tslDpcWhs-HApQ.VoRMLPGGh.VlGlal..hs...s.thh.pp..p...phhpplhh.......................tpphhshh..p..pphs-plhlals.ss..+...+hhC+shsh.s...spush+PsDaKap......th.spWhplcCshphshhlPls......tsss..shc......cphppsl.pth..s+.pl.psuhhl..lsGp...lhtpctsL....................................................................................s..tttpt..plpllh.h.......................tssppp.stplp.ssGslphpGslps+Aalps.+splp-.AhpslKcDllpol..tsRh-lhh-slh.sp..tpt....t.................................h.hP+Rlhhsh.ut..............slhhsDYhFtsEsspchhpphh-hLshphp.pth............................	0	38	54	83
+14630	PF14779	BBS1		Ciliary BBSome complex subunit 1	Coggill P	pcc	Jackhmmer:Q32MM9	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS1 predominantly localizes to the basal body and or transitional zone of ciliated cells. It has been found in a heptameric complex with BBS2, BBS5, BBS7, BBS8, and BBS9, termed the BBSome. Mutations in BBS1 can lead to retinal inadequacy [4].	27.00	27.00	38.60	33.40	24.30	22.90	hmmbuild  -o /dev/null HMM SEED	257	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.66	0.70	-5.41	14	145	2012-04-13 12:46:37	2012-04-13 13:46:37	1	7	104	0	91	136	1	216.40	41	43.55	NEW	KWLcA..phDssusLaThSoClsLuDlpuDG-h+LlluDlG..s.tstph...KLKVa+GsplhoEpsLsDlPoulsoFhh-ppEPRhPsIAVAsGsslhlYKNh+PYaKFTlPuh-lssLEp-lW+pst.tsclss.sLcphL-s.L+s.hutt.pLos+S.caLpLc.c-htuFlppapsssltRposITsMsolKKsou-psulSCLVluTEsG-lalLDspAF....slLhp.......hslsSl........so..Gpas...l-aRlsVusRsGslh..hLRR	........WLpA...hh...-shAslpshSuClsLu..DlpGDG-h+LlluDhu.........t..p.....+LKVh+GstlhpEpsL.slPsuhssFh.h-p.p-.P...+.h.....P..slAlAuGsslalY+NL+PaaKFolPtl..ssh.Et-lWppht.ps.plss...shtp...hLcs.l+p...hst...L.ShpShchL.tl.c.........p-.....h.ttFl..pp...a...+s..pslt+pssI...Tshssl++s.s-csusSCLVlGTEstclhlLDspuF.slltp..................hpls..usPs....hltss..Gpap.l-aRlssusRsGplYhl+............................	0	37	46	72
+14631	PF14780	DUF4477		Domain of unknown function (DUF4477)	Coggill P	pcc	Jackhmmer:Q6NW34, Pfam-B_4074 (release 26.0)	Family	\N	24.90	24.90	25.10	25.70	24.60	24.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.85	0.71	-4.92	18	140	2012-04-13 15:23:06	2012-04-13 16:23:06	1	4	103	0	86	128	0	160.00	28	39.79	NEW	WNchcLppPshsoh......psppshhlcslhtslschlppLpu....pph-pEuAlLsRllY+h+NpF+pp+uapulpplppsLpRLhphsLspslpslpshLPs......sspstssslPo+sslEalLVRlLGhsKLhhRlh-sCppAhphhspplp.saFhphsslhhuhluRla.lL.s+slhppsssLYscLhs	.........................................................................hh..hpp.....ptLptEssll.ptllYpp+Nphtppp.ahtLppVcpsL++LpphsLpsslpsl........hplh..ss............................pst.th...lPo......ps......s.....h..-......h.lhh+lLGss+LlhRlh-sCpcshhhhsppLthp.Fh.hsllhhulluRlh.lL.hptlLtchh.lYp.L..t.......................................	0	21	37	62
+14632	PF14781	BBS2_N		Ciliary BBSome complex subunit 2, N-terminal	Coggill P	pcc	Pfam-B_5448 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [5].	26.30	26.30	27.80	32.80	24.70	23.40	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.62	0.71	-4.54	26	130	2012-04-13 16:13:47	2012-04-13 17:13:47	1	10	98	0	86	119	1	128.20	45	19.35	NEW	l.slG+aDGppP..sLssAT.suGKVhlHsPappttts............ppsslshLNlNpploulsuGtLp....ssspDhLllGoposllAYDVcpNsDlFYK-lsDGlNulll.G...plus..ppPLsllGGNCulpGFDtcGsEhFWTVT.GD	...........................slG+aDGh+P..sLssAT.puGKVhlHsPHppsth.st..................s.cuclshLNINpslosLsAGhLps......p.shDsLllGTpTsLLAYDVhsNsDlFY+E................ls.DGsNul.llG................pl..Gs.....hss........PLsllGGNCulpGFDt-Gs-lFWTVTGD......................	0	36	44	70
+14633	PF14782	BBS2_C		Ciliary BBSome complex subunit 2, C-terminal	Coggill P	pcc	Pfam-B_5884 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [5].	25.00	25.00	25.60	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	431	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.63	0.70	-12.15	0.70	-5.91	25	156	2012-04-13 16:18:48	2012-04-13 17:18:48	1	11	100	0	98	140	0	345.70	40	60.16	NEW	oGEVlaKDshsu..ulAulltuDYRhs.GpspLIssSlDG-VRGY.........sstpppssthpsssppctlccL.p+KQsLhhELcshEcshctt..............tssspsshIPssTplpsslpss.....ppspl-LsluTsN...-olI+usllFA..EGlFc.GEoaV....pssssosslclsLhss..+Dssl-l+lKshVGhp.sSspa+VFElohpLP+FsMYthspss.s................pPsuhVsFpls-..RhpRlshWlspsF..hlsptlp.......tssshclphhsLR...ssps.Lhlchssss.........plpIpoDch-lAGDllQuLssFl......slc.-lpspu-FPtphccLcplLp+Vs-hpulRt+Lou-hADpushlKslllRAEDARllsDhcsM++hYsELhslN+-LlspaphRssN+scLlssLKclNphIQ+Au+LRlGpsKspllusCRsAIKsNNlpuLhcII+	..................................sGEVlaK-shsu..slAullpuDYRhs.Gp.pllssos-Gc.lRGY.............stt.psshhtts.ppphlccL.p+KQsLh...............hELpshEpp.t................tttsphshlsssTplpsshtsp.....ptsph-Ltlssss.......sslI+ulllFu...EulFt..GEohl................ss.pp.ss..plplslhss..KDssl-lclKsh....VGht.sus................papVFEloppLP+FsMYth.t.....................P.uhVphtls-..R.p+l.shWlppsF..llsptht.......pttshplpahslR..sst...lhlphp.ss......................plpl.sDshchsG-llQuhstah.......tlp.chps.spFP..hcchpphh.cVcphppl+t+Lou-hA-pushl+shllpAEDARlhtDhpsM+phYhpLhslNp-Llstapl..........RpsNappLhssLKtlNphIppAu+LR.lGpspspllstCRsAI+ssNhpsLhplhp....................................................	0	45	54	82
+14634	PF14783	BBS2_Mid		Ciliary BBSome complex subunit 2, middle region	Coggill P	pcc	Pfam-B_5884 (release 26.0)	Family	The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme [1]. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialised for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction [3]. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [5].	27.00	27.00	27.00	27.20	26.90	25.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.34	0.72	-4.29	24	129	2012-04-13 16:52:41	2012-04-13 17:52:41	1	11	96	0	83	119	1	109.30	52	16.03	NEW	sVsulslsDhssDGp..sELlVGS-Da-IRlFcs-.-lltEhsEsstlssLsslps.sp.....FuYuLtNGTVGVYcp...ppRhWRlKSKpp.ssultsaDls..u-G..-LIsGWusG+l-sR	.......................pVpSLsLsDasuDGc.....pEL.....LVGSEDF-IRVFKcD.ElluEhoET-tlTuLs.shhs...u+...............FGYA.LuNGTVGVY...-+.......ssRhWRIK..............SKsc.shulpuFDls..uDGVsELITGWSNGKlDsR.......................	0	33	41	67
+14635	PF14784	ECIST_Cterm		C-terminal domain of the ECSIT protein	Godzik A	adam	Jackhammer:Q9BQ95:268-396	Domain	This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain	25.00	25.00	27.00	27.30	21.00	20.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.62	0.71	-4.18	23	98	2012-04-15 05:32:46	2012-04-15 06:32:46	1	4	81	0	63	105	0	119.00	40	31.59	NEW	SspQpcLLpcpshscPlaVEGPaplWL+cpslsYalL+u-..s.....pshs..p..pp--.hD.....Dssslhhs.h.hhchphpp......p.t.stthoVHEQ-DGTIaA.hCsTGsuo+sSLLuWIRhLpc..sNPsLsplPVlF+Lp	.......SP-QpthLucHsss+PlaVEGPFslWLRs+sl.YalLRAD......hP.p.....-cc.p-.hc.....-..slhhP.h.h.chchsR......psh.shphsl.c-..--GslFA.hChsG.spspsoLhpWIptLQc..sNPsLuplPVlFRL.....................	0	21	26	46
+14636	PF14785	MalF_P2		Maltose transport system permease protein MalF P2 domain	Eberhardt R	re3	CATH:2r6g_F_03	Family	This is the second periplasmic domain (P2 domain) of the maltose transport system permease protein MalF [1-2].	22.00	22.00	22.00	22.90	21.60	21.90	hmmbuild  -o /dev/null HMM SEED	164	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.99	0.71	-4.37	57	692	2012-04-16 10:16:57	2012-04-16 11:16:57	1	2	684	8	63	308	12	159.70	61	31.20	NEW	LoaERAQsVLhsRpaQu..GcsasFsLY..ssssp.apLtLpss-ttph.........hlStsFsl..stsss............pplsLs.sss..spGEtAsl+sIspsR..pALsslshhLPsGs.cLpMSuLRpFuuspPLYo............lpcDGpsLpNspoGpha+PNh-hGFYQslstpGpa.tu-plSPGFTVslG	..........................................................................................................LTFERAQpVLhDRSaQA..GKTYNFGLY...PuGDE.WQLALoD..G..E..TGKp..........YLSDAFpF..........GGE..............QKLpLKETsA...PpGERANLRlITQNR..pALSsITAlLPD....Gs...KVhMS..SLRQFSGTpPLYT............Ls.sDG.TLTNNQSGVKYRPNNpIGFYQSIsADGsW.G-EKLSPGYTVThG........	0	11	23	46
+14637	PF14786	Death_2	DEATH_2;	Tube Death domain	Coggill P	pcc	CATH:1d2z_B_00, Pfam-B_14779 (release 26.0)	Domain	This Tube-Death domain has an insertion between helices 2 and 3, and a C-terminal tail compared with the Death domain of Pelle proteins in Drosophila. The two N-terminal Death domains of the serine/threonine kinase Pelle and the adaptor protein Tube interact to form a six-helix bundle fold arranged in an open-ended linear array with plastic interfaces mediating their interactions. This interaction leads to the nuclear translocation of the transcription factor Dorsal and activation of zygotic patterning genes during Drosophila embryogenesis, and is assisted by the significant and indispensable contacts in the heterodimer contributed by the insertion and C-terminal tail described above [1].	25.00	25.00	27.50	32.70	22.80	24.70	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.84	0.71	-4.46	4	45	2012-10-01 21:41:45	2012-04-16 14:44:21	1	2	33	2	20	49	0	117.20	54	27.18	NEW	YoRsTElR+Vp-.Dl.cLApIL--s..WRpLh.lIP++l.DVptsuGuhh..a..h.....hKYsupp.pplDctApRl..spupuphhl-EWtTSGKLsERPTlGhLLpLLV+uphapAADaVAlchLpEspPARPssGPAAhIsl-	...........ElR+l...th..pLsplL..p...st.W+plMshlPpt.......................hKYoupcl..I-psApRh.PcQStSQlMIDEWKTSGKLNERPTVGVLLQLLVpAELaSAADFVALchLNEspPsRPsDGPuA.ISL-.......	0	5	7	17
+14638	PF14787	zf-CCHC_5		GAG-polyprotein viral zinc-finger	Coggill P	pcc	CATH:1cl4_A_00	Domain	\N	27.00	27.00	27.00	27.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	36	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.54	0.72	-7.84	0.72	-4.46	12	108	2012-10-03 11:39:54	2012-04-16 15:14:35	1	20	40	2	36	128	1	33.90	51	5.38	NEW	ssslCPRCtKGhHWAs-C+S+hDhpGpPLss.cpps	....sPsLCPRCKKGpHWAs-C+SKhDhpGpPLss.ptp...........	0	16	19	23
+14639	PF14788	EF-hand_10		EF hand	Coggill P	pcc	CATH:1djx_B_01	Domain	\N	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.88	0.72	-8.58	0.72	-4.30	12	227	2012-10-02 16:17:27	2012-04-16 16:04:36	1	18	55	20	99	189	0	50.60	47	6.86	NEW	.KMSh+ElKphL+.lNlElcDpYAcpLFpcCD+SpoupLEupEIEcFY+hLT	..............KMSF+ElpslL+hlNl-hc-pYAhp.LF.....pcs..D+..S.p.o......spLEscElcpFY+hLT........	0	12	24	51
+14640	PF14789	THDPS_M		Tetrahydrodipicolinate N-succinyltransferase middle	Eberhardt R	re3	CATH:2rij_A_02	Domain	This is the middle domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [1].	25.00	25.00	26.00	25.20	20.20	24.60	hmmbuild  -o /dev/null HMM SEED	41	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.53	0.72	-7.85	0.72	-4.01	68	856	2012-04-17 07:42:46	2012-04-17 08:42:46	1	5	812	32	164	575	309	40.80	44	11.94	NEW	LsNVAW.TstGPhpl-tlcpsclphRh.pGph.lpVhuVDKFPR	....LsNVAW.TspGPhclstlcpschc...h.....Rh.pG.........t.........h...lsV.sVDKFPR........	0	42	107	149
+14641	PF14790	THDPS_N		Tetrahydrodipicolinate N-succinyltransferase N-terminal	Eberhardt R	re3	CATH:2rij_A_01	Domain	This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [1].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.92	0.71	-4.63	21	296	2012-04-17 07:43:41	2012-04-17 08:43:41	1	2	295	22	35	170	92	135.90	44	36.33	NEW	-cFKshVc-lpup.pGYK-PlAFGIARVDhGQhsucKlLQAoYPllNWc.ENaGSAAlFlpAlpcsGlplDFosSEhVhslspcFlppALphFsPalsEAhu-..uHKNlQVlpsLppthccst......pscF+lVFlFEDssPcSVEulYLKLYALSLuKAsLRSlNLsGAFG	.................................................................................pcFh.hlpphppp.stY+cPhuFGIARlDhu.h.ppKlLpAoasllNap.pNhGShAlhhpuh.pp......t...h..c.ptSEhV..lp.p.l..ALtha.pPalpE...p...uHpNIp....llh..lhct.hc-.s.................................ashVhLaE..DccP.SVEusYLKLhLLSp+KVsLRSlNLsGhFG.....................	0	10	27	34
+14642	PF14791	DNA_pol_B_thumb		DNA polymerase beta thumb 	Eberhardt R	re3	CATH:2van_A_03	Family	The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the thumb domain [1].	25.00	25.00	25.20	25.00	24.40	24.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.53	0.72	-8.85	0.72	-4.28	209	1268	2012-04-17 13:11:18	2012-04-17 14:11:18	1	39	923	222	528	1126	238	66.10	35	12.07	NEW	ALhYFTGSctaNhplRphApcc.Gh+LsEaGlac.................sp..........tp..................h....l..ssp.....................oEc-laptLGLsalsPchR-s	..................................uLhaFTGS+paNhphRph.App+.uh+lsEaGlhp....................h..ss..........sp...........................................hl.php..............................................................oEcclactlGlsalsPp.Rc....................................	0	177	300	418
+14643	PF14792	DNA_pol_B_palm		DNA polymerase beta palm 	Eberhardt R	re3	CATH:1bpd_A_03	Domain	The catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain [1].	25.00	25.00	25.00	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.76	0.71	-4.01	47	629	2012-10-02 22:47:23	2012-04-17 14:17:36	1	31	308	209	368	663	146	118.30	26	21.74	NEW	RIPRcElptltshVp.ptspplsPs........hpshlsGSYRRGtsoSGDlDlLIT+scspst..................hp.........shLspllppLpp.......psFLscsL...........ut........us............sKahGlCpLss........................s...............thaRRIDlhllPt	..........................+hPRpEspth.tphlp.c.t.s.p.tlsss..........hh.sslsGSYRR.............G+.t.s.u.G.DlDlLlT+sctss........................................p..............tllppllppLcp........ps.alp.p.s..L........................................s.........t.....................................ta.hG.t.h.....................................................................................................hRRlDhhh........................................................................................................	0	113	187	273
+14644	PF14793	DUF4478		Domain of unknown function (DUF4478)	Eberhardt R	re3	CATH:3bq9_A_01	Domain	This domain is found in bacteria, and is approximately 110 amino acids in length. It is found in association with Pfam:PF03641 and Pfam:PF11892.	25.00	25.00	25.20	71.90	19.80	24.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.33	0.71	-4.48	51	869	2012-04-17 14:13:23	2012-04-17 15:13:23	1	3	864	10	131	454	72	111.60	69	24.98	NEW	hpsplsPtGoh-lLSQhEVs+L.ppsususLYpLFRsCuLAVLNoGupoDsucplh-pYp-F-IpllpcERGlKLELhNsPtpAFVDGchIcGIpEHLFuVLRDIlYlssclpp	......Is+lSPh.GSMDhLSQLEVDhL.K+.TA.SSDLYQLFRNCSLAVLNSGShTDNSKELLsRaEsFDINVLRRERGVKLELlNPPE-AFVDG+IIRuLQspLFAVLRDILFVtuQIcs....	0	22	52	94
+14645	PF14794	DUF4479		Domain of unknown function (DUF4479)	Eberhardt R	re3	CATH:3bu2_A_02	Family	This domain family is found in bacteria, and is approximately 70 amino acids in length. The family is found in association with Pfam:PF01588.	25.00	25.00	27.20	27.10	24.20	20.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.84	0.72	-9.12	0.72	-4.44	90	1013	2012-04-17 15:01:32	2012-04-17 16:01:32	1	4	989	4	85	461	0	72.60	40	36.05	NEW	tsssstctshE++GsVs+Ihs.tcsspslGaNlFssSshl.plpu.sGpVpLoc-plspLNptLpcsGFsppLpsDh	..........tpsstuchsh-RKGsVsRlhp.c-sGpsVuaNIFclSs...hl.pIpp..pGpltLTDE.VsplNptlpcsGFsccLssD.......	0	18	42	65
+14646	PF14795	Leucyl-specific		Leucine-tRNA synthetase-specific domain	Coggill P	pcc	CATH:1h3n_A_03	Domain	This short region is found only in leucyl-tRNA synthetases. It is flexibly linked to the enzyme-core by beta-ribbons structures [1]	25.00	25.00	38.20	83.10	18.90	16.40	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.66	0.72	-4.11	9	12	2012-04-17 15:26:50	2012-04-17 16:26:50	1	2	12	10	6	14	0	55.90	70	6.37	NEW	.WTDaGPVEVEGspVR.LsEssRlRLEl.EutLSLE-V+KMGAELRsHEDGTlHhWKP	WTDFGPVEVEGstVR.LPEPTRIRLElsputLSLE-V+KMGAELRPHEDGTLHLWKP	0	1	4	6
+14647	PF14796	AP3B1_C		Clathrin-adaptor complex-3 beta-1 subunit C-terminal	Coggill P	pcc	Pfam-B_195384 (release 26.0)	Family	This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules [2].	27.00	27.00	27.40	27.50	25.70	26.90	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.77	0.71	-4.50	25	196	2012-04-17 16:02:19	2012-04-17 17:02:19	1	7	100	0	118	173	1	141.10	38	13.89	NEW	s+ss.s.LLDL.DD.......sPsssP.....lloPSLsusLpshohosssssss............lsuPual...sh+spELLp.+loGcGLulpYRFoRpPplauspMVSlplpFoNpospclpsI+lup+.pLsuGMplpEFspIsp.LtPptShosslGIDFsDSTQ	................................................................s..tpph.LLDL.-Dat........s.ss.P......hlosSLhuDLpGLslosos.s.s.............................lhoP..shh...ssKppELLH.+h.s.GcGLulcYpFsR....p....Pph.......hs..spMVo.....lplphsNso-.p.pIcsI+lGpp.cL..ssGh.plpp...Fs.I-s.LtP.tt.o..hT.sshGIDFsDSTQ................................................	0	25	42	75
+14648	PF14797	SEEEED		Serine-rich region of AP3B1, clathrin-adaptor complex	Coggill P	pcc	Pfam-B_195384 (release 26.0)	Family	This short low-complexity, highly serine-rich region lies on clathrin-adaptor complex 3 beta-1 subunit proteins, between family Adaptin_N, Pfam:PF01602 and a C-terminal domain, AP3B1_C,Pfam:PF14796.	23.00	23.00	25.70	24.20	19.10	19.10	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.39	0.71	-4.00	16	46	2012-04-17 16:15:25	2012-04-17 17:15:25	1	3	27	0	20	41	0	130.00	69	12.64	NEW	sssKKFYSESEEEEDSSDSSSDSESESGSESGEQ...sEEGDSoEDSSEDSSSEQDSESGSESEsEsKRsAKRNSKoKGKSDSEDtEKENEKSKTSDSSssESSSlE-SSS-SESEStSESESESR+VTpEKE	...NsuKKFYSESE.....E....E..EDSSDSSSD..........S................E............SE..SGSE.SGEp...sEEGDSSEDS...SEDSSSEp.-SESGpESthEsKRsAKRNSKsKGKSDSEDGEK.E.NEKSK...TSDSSsuESSSlE-SSSDSESESESESESE...SRKVTKEKE.....	0	1	1	4
+14649	PF14798	Ca_hom_mod		Calcium homeostasis modulator	Eberhardt R	re3	Jackhmmer:Q86XJ0	Family	This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels [1].	25.00	25.00	30.70	27.20	22.10	21.50	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.78	0.70	-5.42	30	292	2012-04-18 15:03:15	2012-04-18 16:03:15	1	2	49	0	174	237	0	231.90	33	77.89	NEW	M-pa+hlhpahpspcsolhsullulLTluupclFShhsFpCPCssshNhhYGlshLhlPAlsLhllGhhlNspo......W+lssG.............+.hpptppssh.hhlhssIhtpAhlAPlsWlsVuLLsGpaY.CAhSs.ssssth....t.hss...psscstchLu+lP.Ctc.hss.....pcplhphL+spSQlLGWhLlsllslluhl.spClppChS.loaLQhcaWppYhcpEcc....lF-ppsppHAcphAccNl+pFF-shpsp.	......................-tFphlhpah...spptslh.ulhulhsluutplaSshsFpCP.C.sshN.hhYGhshLhsPslsLhllGhhlNsps......WchhsG.......................ppt.p..ssth..hhhhsplhtp..AhlAPlsWlsVsL.LsGp.....h.a..CAhSt..ssspth.......hsp....hp....sspstchLs+hP.Ctc..h..s.......p.ctl...hthL+spSQhlGWhllhlsslhshl.spslppChS...l.oaLQtpaWppYhppEcc....lF-psspcHActhAcpslcpFFtthp..p.............................................	0	21	35	73
+14650	PF14799	FAM195		FAM195 family	Eberhardt R	re3	Jackhmmer:C9JLW8	Family	\N	25.00	25.00	26.30	25.60	23.40	23.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.48	0.72	-4.15	32	165	2012-04-19 08:00:36	2012-04-19 09:00:36	1	2	77	0	90	155	0	98.80	36	68.81	NEW	.pssssP+sVFpp.ss+ph.....tts.pptpp......pEshostHEE.l+aIp-uWppV.pp.tts.....................................sss......tstpusshYhpcsPsssLpsFpPhDLEpWWucRhhsNIsp	...........................................................h.pssss+hVap....Nu+Rt......ss.s.s.pss.....pEsaTssHEENVRFlhE.........AWppVppphpst................................ss......tpssts.pYh.EcsPsPpLpsFpPhDL--aWupphhssIt........................................	0	16	22	55
+14651	PF14800	DUF4481		Domain of unknown function (DUF4481)	Eberhardt R	re3	Jackhmmer:Q5VZI3	Family	\N	25.00	25.00	26.70	37.70	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.93	0.70	-5.51	5	86	2012-04-19 09:33:35	2012-04-19 10:33:35	1	3	66	0	51	93	0	236.00	39	63.81	NEW	WRNGQsVhuVPTSShhoP.SFDLSlCRsLLEocGFQIPAu-FEsPLElALDcPSVRRYLlFNSplF+FIMAPIlYlVlWCAlYSTLHLY...SlucYWlLCLsVSLVSIhLTssIlLIlcYSNKEINMNTDVRLluVNERLlRH+LLLGVADWVcsCpGsLQLFhVYWDlu+CL+uLTEoL-EM+FupDpuQphL+KRMSHLlLVsEVsoh-PsA..u....sEG.S-..EEpPLLsusEE.suE.polSQR-DoKLTcNaSLVP-shLsspshApQLLlsYGAlYVRLLVSs+L.sssppPpssu+NHCsuu.slChCQYIc	.............................................h..NGpV.lss.L..hs.s....hhsPhtFc.ths.EpL.s.Glp....lss-pYhshhEohl.-..hhRahlYN.p.hRlhh..s..hlh..a..lVlhu.laS...s.......Qhh....uLushhs.uhLhlshA.Al.LshhlhLhhp+tpcKhNhNh-hpLAtsNttLhRH+lLLGlsDpschspphlpLhFlYFDhppCVpaLs-alp......chcpst.-..sh....hcp+Ls.....................................................................................................................................................................................	0	11	15	31
+14652	PF14801	GCD14_N		tRNA methyltransferase complex GCD14 subunit N-term	Coggill P	pcc	CATH:1i9g_A_01	Domain	This is the N-terminal domain of GCD14, itself a subunit of the tRNA methyltransferase complex that is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [1]. The exact function of the N-terminus is not known but it is necessary for maintaining the overall folding and for full enzymatic activity.	21.90	21.90	21.90	22.50	20.70	21.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.24	0.72	-8.70	0.72	-4.39	11	435	2012-04-19 10:01:56	2012-04-19 11:01:56	1	2	432	1	112	324	79	53.60	53	14.52	NEW	.RRGsLpAGEKVQFTDRKGKKITDQLVsGGVTQTEHGlILHDDVIG+oEGsVlT	.....t..pGPFpsG-RVQLTDsKGR+aTlsLpsGupFHTH+GultHD-lIGts-GoVV....	0	33	82	104
+14653	PF14802	TMEM192		TMEM192 family	Eberhardt R	re3	Jackhmmer:Q8IY95	Family	The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome [1-2]. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time [3].	25.00	25.00	25.30	25.00	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.48	0.70	-5.51	19	137	2012-04-19 10:17:44	2012-04-19 11:17:44	1	2	88	0	80	139	0	206.00	32	76.71	NEW	D.ss.hhsssLtSt..cspFcslsTVhhssl.llls...lslslsuhlhshhhsspptcC........csahlllYh+sshWllshlh-phs+p+HpplRhpGYhcFYRpTpph++lPLhlhShsNssLLhltslhpphh...............tpsh.t.t.....Loshhaltlls.lEhllhlsshlhYhs+Vh+FN+t+s.PDlhc--ph...h..s.phssphGh.pcusshEEllEKQADlIcYL+cHNspLu++lhpLs	...........................................................h.t..h.s...p.pFp.l.Th.hhslhhhlp...........shlshhshhhs.h.....tp.pC................ps.hlhlhh+shLWllphlh-palph.pHp+lR.pGYhphacpT+pl+plPLhlhShGNsslLllhsh.tph................t.sh..........L...hhlslhs.lEhlsshhshhhYhs+..lp+.FNpt+spPDllcppt..........s.phhsphGh...+pssshc-llEKQuDhIpYL+cHsthLsc+lhth..........................................................................................	0	16	28	57
+14654	PF14803	Nudix_N_2		Nudix N-terminal	Eberhardt R	re3	CATH:3cng_A_01	Domain	Ths domain occurs at the N-terminus of several Nudix (Nucleoside Diphosphate linked to X) hydrolases.	25.60	25.60	25.70	25.80	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	34	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.89	0.72	-4.26	89	442	2012-04-19 11:54:43	2012-04-19 12:54:43	1	3	377	4	170	392	347	33.50	47	17.74	NEW	+aCspCGss.l.ph+lP.tGDs+.RhVCssCstIHYp	......+FCstCGps.l..tt+IP..tGD..sR.RhVC..s..s.CusIHYp...	0	43	94	138
+14655	PF14804	Jag_N		Jag N-terminus	Eberhardt R	re3	CATH:3gku_C_01	Domain	This domain is found at the N-terminus of proteins containing Pfam:PF13083 and Pfam:PF01424, including the jag proteins.	25.00	25.00	25.40	25.10	24.80	24.70	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.10	0.72	-3.95	270	1458	2012-04-19 14:54:28	2012-04-19 15:54:28	1	7	1341	3	281	989	174	51.90	36	17.81	NEW	chpG+Tl-EAlppAhpcL.sls.c-cl.-l..-Vlpcs.spGhhG..lGpKsAhlclphc	......hpGpTlEEAlppuLppL.sl....s.+pcl...cl..cVlpc..s.+KGFLG..hG.+KsAhlclp.....................	0	137	226	247
+14656	PF14805	THDPS_N_2		Tetrahydrodipicolinate N-succinyltransferase N-terminal	Eberhardt R	re3	CATH:3gos_A_01	Domain	This is the N-terminal domain of 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [1].	25.00	25.00	25.20	25.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-9.31	0.72	-4.11	262	1625	2012-04-20 07:44:11	2012-04-20 08:44:11	1	6	1605	15	423	1040	1377	68.40	52	24.78	NEW	spLpphIEsAaEs.Rspls..t....sssscl+cAVppslshLDsGplRVAE+.h...s......Gp............WhVNpWlKKAVLLuFRlp	.....................pLpslIEsAFEc..RApIo..ss.....sscstsR-AVppsIshLDsGtLRVAEKh....D..............Gp................WsspQWLKKAVLLSFRlp.........	0	118	254	339
+14657	PF14806	Coatomer_b_Cpla		Coatomer beta subunit appendage platform	Coggill P	pcc	PF07781	Domain	This family is found at the C-terminus of the coatamer beta subunit proteins (Beta-coat proteins). It is a platform domain on the appendage that carries a highly conserved tryptophan.	25.00	25.00	29.80	29.20	22.20	21.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.62	0.71	-4.44	30	371	2012-10-01 20:40:43	2012-04-20 16:04:06	1	9	303	0	267	372	4	123.70	54	14.51	NEW	uDcssVlLNDIHIDIMDYIpPAp..CsDspFRsMWsEFEWENK.VsVpT.sls.sL+sYLcHlhcsTNMpCLT...P-uuLsG.-CsFLuANLYA+SlFGEDALANlSIEK....sscGpIsGalRIRSKTQGlALSLGD+Is	...................................s-pssVlLNDIHlDIMDYIpPAs..Co..-spFRp.MWsEFEWEN..K.VsVso.......sh...p..........sL+-aLpclhcuTNMpCLT.................P......c...t.........u........L........sG....c.............CtFluANLYA+Sl.FGEDALANlSIEK.............ts-u.l.sGal.RIRS.KoQGlALSLGD+l...............................	0	99	154	223
+14658	PF14807	AP4E_app_platf		Adaptin AP4 complex epsilon appendage platform	Coggill P	pcc	Pfam-B_21377 (release 26.0)	Domain	This domain is found at the C terminal of clathrin-adaptor epsilon subunit, and at the C-terminus of the appendage on the platform domain.	27.00	27.00	29.90	28.50	26.50	25.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.34	0.72	-3.80	12	75	2012-10-01 20:40:43	2012-04-23 09:50:09	1	2	55	0	53	74	0	102.90	41	9.81	NEW	RPLploT--FGthWhSh.up-hcQslp..psstsslsshLpthpppL+LHsVplIGs....EsIhAspLLssss......CLlHs+lsus.slslhl+osspsLs-slltpCppshp	....RPLpIoT--FGchWlSh.us-sKQslp..spot..ssLs.ssLp.sLpp+LpLHlV-lI.Gs....EGllACpL.Lsohs......CLLHsRl.....pus..sluLWhRSssssLsDhLLhpCQ+sh.................	0	22	26	36
+14659	PF14808	TMEM164		TMEM164 family	Eberhardt R	re3	Jackhmmer:Q5U3C3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 214 and 330 amino acids in length. There are two conserved sequence motifs: LNPCH and DPF.	25.00	25.00	25.30	26.70	20.40	21.40	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.59	0.70	-5.18	10	165	2012-04-23 10:24:12	2012-04-23 11:24:12	1	5	104	0	108	146	1	193.00	37	75.81	NEW	hhDWsYGGVDsSls.GNGGPECAsFLospQRllEollhhsLuhhtlhhulc+lt.................spsssttppcssu+plLLlhLslsFGlElGFKFAo+TVIYLLNPCHlsTslQIYLLAss.PS+psTslFRLpMahLNGAlLAlLFPllNTRlLPFEhEIYYIQHlLla.VVPlYLL+hGGsYssEPlsDapWulLuhGLhhhYHFslLQlLullTpVNLNNMLCPAlSDPFpG.aYRIaAssHQsLLshlpuKLhshlh	..........................................................................................................h........................hhs..p+hhE.hhh..h.hh.hhhsh..h......................................tp..c.hllh.....hhsh.hhuhphuaKhsp..t....ph..l....ahLpPCHlho..hhp.l.hlLhh.........p...hshhlF..pl..hthl.GshlAhl.FP.h...ssRhls.hEhthYalQHhhlh.llPlYLlh..sG.sYs...........Esht..shtWshl..u.........hulhhhYHFshLp.lul....h..............TtlNLNpMLCP....A..hpDPF.......G..YRlhA.hHQslhh.hhsKhhhh..s...................................	0	50	56	84
+14660	PF14809	TGT_C1		C1 domain of tRNA-guanine transglycosylase dimerisation	Coggill P	pcc	CATH:1iq8_A_02	Domain	This short region of the tRNA-guanine transglycosylase enzyme acts as the dimerisation domain of the whole protein [1].	25.30	25.30	25.30	110.90	25.20	23.10	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.34	0.72	-4.16	5	13	2012-04-23 10:52:57	2012-04-23 11:52:57	1	1	13	8	11	15	0	70.00	73	12.05	NEW	PITKKSAFFKISEESL+WPIVRRAKERAERVsuKFPEpVcHPIFGEIPKYLSLTYPFAQSEuEEDFoIEK	PITKuSAFFKVSEEuL+WPIVpRAKERAERVppKFPEslpHPIFGEIPKYLSLoYPFAQSEGEEDFTIEK.	0	1	1	6
+14661	PF14810	TGT_C2		Patch-forming domain C2 of tRNA-guanine transglycosylase	Coggill P	pcc	CATH:1iq8_A_03	Domain	Domain C2 of tRNA-guanine transglycosylase is formed by a four-stranded anti-parallel beta-sheet lined with two alpha helices. It has conserved basic residues on the surface of the beta-sheets as does the C-terminal domain PUA, Pfam:PF01472. The catalytic domain, TGT has conserved basic residues on the outer surface of the N-terminal three-stranded beta sheet, which closes the barrel, and it is postulated that these basic residues from the three domains form a continuous, positively charged patch to which the tRNA binds [1].	25.30	25.30	25.50	26.50	25.20	24.70	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.78	0.72	-9.27	0.72	-4.13	62	193	2012-04-23 13:13:56	2012-04-23 14:13:56	1	5	144	8	131	194	27	71.10	29	20.27	NEW	lpplRsIADYQFGtGAGcsLFs-p...hplphS.pTG+lRplhsssc.plATl+usDGhhoLultGAcRLpcshshPp	.....................tl+slA-YQFGtGsu.c.tLhsct....hplphS..pTs+l.Rplh.....t.....s.........sc..pls.olRupDGhlsLoltGAchLpphh..P..........	0	31	81	109
+14662	PF14811	TPD		Protein of unknown function TPD sequence-motif	Coggill P	pcc	Jackhmmer:Q9Y2V0	Family	This is a family of eukaryotic proteins of unknown function.  A few members have an associated zinc-finger domain. All members carry a highly conserved TPD sequence-motif.	27.00	27.00	29.60	30.20	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.28	0.71	-10.81	0.71	-4.65	33	149	2012-04-23 14:17:28	2012-04-23 15:17:28	1	2	114	0	101	150	64	132.30	41	47.79	NEW	ls-pcLtt-ltpsl..hsDp.huPls-ph+.......cshGpEaEhhLcchLcptslsFhsEcc.LRtpGasK........TPDl+LplPlslcGp.....lVsWIESKA.FGD...pcsH..pphhccQh.uYhNRFGP.GhVIYWaGal-.....pl..sp..t.........lll.........hD.pFP	....................................D.hLutpl.pCl..hsD.stauPlsDph+.......+shGpEaEhhLcchLhptsl...sFhsEcp.LRtcGYDK.........TPDhhLp...lPl......ul..cGp.........................llpWIESKAsFGD.......cpoH....psa.lccQahSYhNRFGP.GhVIYWaGalp-l..st..p...tlhlhs.t....................	0	43	56	78
+14663	PF14812	PBP1_TM		Transmembrane domain of transglycosylase PBP1 at N-terminal	Coggill P	pcc	CATH:3fwl_A_01, Pfam-B_367 (release 26.0)	Family	This is the N-terminal, transmembrane, domain of the transglycosylases ()penicillin-binding proteins), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The TM domain is a single helix, several of whose residues lie in close proximity to hydrophobic residues in the TGT domain. The TM helix seems to be necessary for stabilizing the protein-membrane interaction, and the resulting orientation limits the interaction between PBPb1 and lipid II in the membrane in a 2D lateral diffusion fashion [1].	27.00	27.00	27.00	27.00	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.37	0.72	-3.67	26	562	2012-04-23 14:23:22	2012-04-23 15:23:22	1	8	557	2	46	248	3	78.00	74	9.53	NEW	MS.sDDREPIGRKGKts..pss+ppss.+pRRRcDD.....................--..DDD..p..E.--csMsRKsKs......p.s+pKR.RW.LhLLlKLhlV.FsVl	............MA.GNDREPIGRKGKPo..RPVKQK..VSRRRhcDDD........................D...D..D.YDD....E..DEEPM.PRKGKGK........GR.KPRGKR..GW.LWL.LLK..LhIV.FAVL................	0	3	11	28
+14664	PF14813	NADH_B2		NADH dehydrogenase 1 beta subcomplex subunit 2	Eberhardt R	re3	Jackhmmer:O95178	Family	This family represents an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis [1-2].	25.00	25.00	25.90	27.00	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.08	0.72	-9.59	0.72	-4.31	12	105	2012-04-23 14:29:09	2012-04-23 15:29:09	1	2	86	0	61	100	1	69.70	46	65.04	NEW	u.stusHl.shYRphPp.ls+tphhtuElluGhMWaWlLWHhWH-s-tlhGHFsYPDsSpWTDEELGIPPDDpE	.................u.tusHl.spYRphPp..lT+p...phhtuEhh.SGhMWFWILW+hWHDs-t.VlG.HFPYPDP..SpWTDEELGIPsDDt..............	0	16	21	42
+14665	PF14814	UB2H		Bifunctional transglycosylase second domain	Coggill P	pcc	CATH:3fwl_A_02	Domain	UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle [1].	27.00	27.00	27.00	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.00	0.72	-9.38	0.72	-4.26	119	1054	2012-04-23 14:40:43	2012-04-23 15:40:43	1	9	1036	2	158	684	84	84.40	46	10.57	NEW	LhsGtslotpplhpELchLsYRps.s.p...sp...psGpa......shpu....splplhpRsFsFsDG.t.Essp+lplsFss.splsplpshps.sp.shuhhRL	.......LcPshslS+sEhlplL-uhpYRpV.o.p...hs...+PGEF......oVpu....so.IEhlRRPF-FPDu.c.Eup..hRsRLoFss.s+LusIhsh-s.sR.phGaFRL................................	0	32	68	118
+14666	PF14815	NUDIX_4		NUDIX domain	Coggill P	pcc	CATH:3fsp_A_03	Domain	\N	35.00	35.00	35.00	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.66	0.71	-4.65	286	3169	2012-10-02 00:00:35	2012-04-23 16:31:00	1	22	3080	6	661	3685	1180	115.00	24	31.12	NEW	shl.lhp.pssp..lL.Lc+RPspG.LhuGLaphPph.-....h..t..................tp.th.................t..t.h...tp...h.shp...sp..h.h.p.....hs.....shcHsFoH.acLcl..p..shh....spls.....pt....t...........s.sshhWhshpp.h.p.p..huLPsshcKllp	........................................hllhp.pp.sp...lLLpc.RPsp...G........L..h.uGLapF...Pt.h.c........t...................p........tppl.........................................................p..p.ht.....pp....h..s.h.s.......ss.........h......p......phs.......slpHs........F....S........H..h+l..cl....pshh..........spls.........st..tst...........................ssshhWhshpp..h.s..s....hulssshc+lh...................................................................	0	191	386	534
+14667	PF14816	FAM178		Family of unknown function, FAM178	Coggill P	pcc	Jackhmmer:Q8IXR5	Family	\N	25.00	25.00	25.10	30.60	23.40	22.20	hmmbuild  -o /dev/null HMM SEED	378	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.42	0.70	-5.75	7	112	2012-04-23 16:07:15	2012-04-23 17:07:15	1	2	42	0	51	106	0	318.10	44	44.42	NEW	tuusphspspusoYsNoL-aLLQEKcp.th.pEhE+.Lhp-h.php..s.D...t-Es......sLs.EHRtllcRFSVohpuIPshHPGEsVF.......l.ppasLs..LcpSplpP+StlEpLhLpSssspQLohlppGLLoshYhpss.CPlslL+WLFQhhoh.P-..sSsthhuhLa-lolcuh.p.oDpssp...hWsPSLp-VstsFashGA+..uLaPLsshQ.sh..csLhuchphopscpQ..ssssphu.DhS......LtplhKFLsLCshspPsAYTDppLLhLItLLC+huL-spL+LLPpsDhQpLLl.LLcNIp-WssKlppLCpsLSplSsHHHNLLtLVQlhP-hoSRuRpLRppLSLVlIA+hLsppcph	...................................................................................................................t..pYhNsL-hLlpEhccp.....t..h..pEh...pc.L.p-h.ph...p.........p.s...t-p.............sL........EHR.hlc.+FSVo..l.psIPshHPGEplF.......l.pp.asLs..Lc..sSthhsp..SslE...pLhL.pSs.spQl.hhppGhLoshY.h.as...CPlPlLp....WLFphhoh.s-..sSsphhuhLh-l.olcs....p...s.Dpshh.....WhPSLp-lstlFhshGh..p..uL.aPLtshQ.sh..csL.....h.u-.sph...o.ttpp.....stspp.ht..hS............lhplh.KFLu.LCs....plpPp..uYpDp-lhhLI.hLh+h.uL-tpL.+.lP.hsDhQpLLl.L.hcNI..+-..WssKl.cLChulsplSsH.HNLLhLVQhhPshToRuR...QLRp.pLSLVlIu+hLsppc........................................	0	7	11	19
+14668	PF14817	HAUS5		HAUS augmin-like complex subunit 5	Eberhardt R	re3	Jackhmmer:O94927	Family	This family includes HAUS augmin-like complex subunit 5. The HAUS augmin-like complex contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [1-2].	25.00	25.00	25.30	25.30	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	632	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.22	0.70	-13.22	0.70	-5.98	8	103	2012-04-24 09:49:48	2012-04-24 10:49:48	1	6	59	0	65	103	0	479.50	25	90.83	NEW	p.ucELtRWAsEEMslPsuu..........tPs-sth++LClGpGAcIWtYllpHV+SpRoV+sIRGNLLWYuttsss...................................clp.........R.........+hELppplpcLRAElpcLDpplpthEpEssup-tuhppuh.......pphp-sp+RpLLLcAastpsc+pp+sLp-shp+LpsQhcpLQ-hpR+Acs-...lsFGsss...SAu...................suLEPtVLRDVRcACshRspFL....QsLLpspsptsSshssp........cDphusSaQpWh.....SuVEslLss.....HPPsplLuALptLsucpcsplcp.LsosD........shp.Ds.....Ehp+........sphsD...................pScsppsLPuhppLlQEuWppVspllsppuplpp..cpQsLsp+LpuhlcEsccc.hlsS.sppssh..............hhpL..cpsslhsslc.uL+spsppLpptsuc+pctl.......RpLQsppQpIh-aRpLs-c+QEQIRhLIK.GNSuuKocLsRsstEltphlpcKLlPshpsVsspSpcLpcslpcEs+HFsplsLu..................................sLh+ppssGhphlPssh.SIHRL.pst..h.......suuhtsLscoLulPh.h+APEtLLspAsoh+p-LlaLpcphuLpupuLhs..l..+suL.Pus..sTQtLLphtppp-Kcph-sLsPpL++LhppscpsLEts.plQullsDWWEQPuQhALsp.pppGLolpQWppR	..............................................................................................................................................tWh.pEhth...............s....t.h....pplChG.p.hh.lWtalhp+Vhppcslphh+tNl..hat..t.t.................................................tht......c..........+..htt.tltpLcs.ltp.ppp.lp.h..pht..tp-.thpp.h.......tphtp.pp+thhLpu.ttthptttp.htp..pplp..hpphpch.t+.tt..t......h.............t...............................hhEs.h.tslRthCp.h.t.h....ptl..s..t.ts.................th.htthh......p.sp.hhts.....hsP..lLtulthhs.c.tt.lpp.hpths........hht-h.....ch.p........................h.s.........................usp....hss..pLlpcth....ttlt.hhsptt.h.p...ptp.hppcL.thhct......hptt..h.t....t.......p...t.tsh...............hhth..chsshhuplp.sLhsps..ppLpphstppp.h........ppLpt+.pcI.cacthhpchpp.hphLl+.uN.sutshhppt.hts.thht...tpllP..t.l...spp.hphlpcEhtth.t...s..................................sl.ptpstt.....Pshh.SIp..pl..psh............................................s.shh.l.ptLths....pusE..h.tshsht..p.hh.hhpp.....t..l.p..h.....tst.....t...stp.hlph.tpp-p...cphh.tl+ph...hppshp..h..lpshltcWa-QPuthsls...h..tG.sh.tW......................................	0	21	36	49
+14669	PF14818	DUF4482		Domain of unknown function (DUF4482)	Eberhardt R	re3	Jackhmmer:Q6ZU52	Family	This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with Pfam:PF11365.	25.00	25.00	25.40	29.70	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.85	0.71	-3.53	13	155	2012-04-24 10:34:25	2012-04-24 11:34:25	1	3	38	0	83	137	1	130.10	34	10.45	NEW	MDL+cQlcpoE+NWp+EKhELL-+FDsER+EWEsQhK.hQ+KIEcLp+EVchRRp.......uphhs.p+-pshpspshpusss.Ppsup....s-hpuhspcDshtpcpKcppslhupp....................s.hscp.phsccscsshhss.sh-.cK	...........................MDLppQlp.poE+NWs+EKlELL-RhDpERppWEpQhKE...Lpp+lc......Q............LpKtsssh......................sl+.t.hptp.p..c..st...h.pDt-shs.t-h.hsphKcscpsou..p....................s.hhcshpLsspst.s..t...h-.p......................................................................................................	0	6	11	31
+14670	PF14819	QueF_N		Nitrile reductase, 7-cyano-7-deazaguanine-reductase N-term	Coggill P	pcc	CATH;3bp1_A_01	Family	The QueF monomer is made up of two ferredoxin-like domains aligned together with their beta-sheets that have additional embellishments. This subunit is composed of a three-stranded beta-sheet and two alpha-helices. QueF reduces a nitrile bond to a primary amine. The two monomer units together create suitable substrate-binding pockets [1].	25.60	25.60	25.60	25.60	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.42	0.72	-3.98	126	1208	2012-10-01 20:59:24	2012-04-24 16:18:52	1	5	1189	25	217	794	335	110.50	60	39.70	NEW	Y.spYDPsLL.PlPRshsR-pLGlss..sLPF.p.GtDlWsuYELSWLNs+GKPpVAluchplPssSsNLIESKSFKLYLNSFNQT+Fso.hcpVppplpcDLSssAsusVsVpl	......................................YtcpYDsSLLQsVPRoLNR-sL....G.....Lpu....psLPF.p.GsDIWThY...EL.SWLN.u+GlPQVAlGclplshsSsNLIESKSFKLYLNSFNQTRFss.....h-p.....VcpTLp+DLSsCAtupVoVpL..............	0	41	94	159
+14671	PF14820	SPRR2		Small proline-rich 2	Eberhardt R	re3	Jackhmmer:Q96RM1	Family	This family of small proteins is rich in proline, cysteine and glutamate. They contain a tandemly repeated nonamer, PKCPEPCPP [1]. They are components of the cornified envelope of keratinocytes [2].	25.00	25.00	38.50	26.20	21.80	23.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.06	0.72	-10.64	0.72	-4.10	4	108	2012-04-25 10:24:47	2012-04-25 11:24:47	1	3	16	0	43	102	0	59.60	78	98.41	NEW	SYQQQQCKQPCQPPPVCPsPKCPEPCPPPKCPEPCPPPhC.PEsCPP..CQcKCPPV...PPCQpKCPP	........SYQQQQCKQPCQPP.PVCPsPKCPEPCPPPKCPEPCPP.PKC....PEP.....CP....P.....ppC.....QQKhPPVp..PPCQ.KhPP..	0	6	6	6
+14672	PF14821	Thr_synth_N		Threonine synthase N terminus	Eberhardt R	re3	CATH:1kl7_A_01	Domain	This domain is found at the N-terminus of many threonine synthase enzymes [1].	25.00	25.00	25.00	26.60	24.40	24.60	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.61	0.72	-3.96	302	3034	2012-04-25 12:31:21	2012-04-25 13:31:21	1	15	2909	4	759	2286	1521	77.50	33	16.58	NEW	cYlSTRG.p....s...sslsFp-slLp.GL.AsDGGLalPc..phPp.lsts.plpphpsL....oYt-LAhclhphFl....s-....Isps-L+sllscuY	..................a.STRs..p........s.......pploFupAllp.GL.Ap.D.GGLahPp..s.lPp.hshs...l.c...ph...tsh..........sa.-hAhclLssFl....s-.....lsp..-pLcphlppAa.................................	0	214	441	611
+14673	PF14822	Vasohibin		Vasohibin	Eberhardt R	re3	Jackhmmer:Q86V25	Family	This family of proteins function as angiogenesis inhibitors in animals [1-2].	24.00	24.00	42.30	25.10	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.45	0.70	-5.29	10	165	2012-04-25 13:13:52	2012-04-25 14:13:52	1	5	72	0	95	174	0	192.10	48	64.09	NEW	GGVPFalNRuGhPls-tTW............ERMWpHVAKhHP.DGcchsp+IRsAsc...LPKlPl................PoVPsF.....psot..oVs-tLcAlQpYl+cLQYNHTGTQFFEIKKsRPLoGLMElAKEMs+ESLPIKCLEAVILGIYLTNuhssLERFPISFKTpFSGsaFRHIVLGla.huGRaGALGlSRRcDLMYKPLpaRTLS-LlhDacsuYccpaHsLcKVKIGtsVsH-PHSsEpI-WKHsVLslp+.hu+EDlRKELE+auRDMR	...........................................s............h....t.hW............ppMa.ashp.ps.pstp.httl+sss....Lsc.sh.................PplPsa.....p.sh..slsphLpslQpYhppLp...YNaTG.sQFFplcK.RPLsuLM-hAKEMh+EuLPIKCLEAVILul......Y............LTsu.ssl-RFPISFKo.F.uG.....sh..........F+HlVLGlh..h...s...G+...Y..GuLGh.SRRt-LM.KPhsa+oLS-Llh-act.uYpphhHslpKVKl.G..VsH-PHShp.IpWKp.lLshp+.hhtt-hc+pLE+asR-hR................................................................	0	28	39	58
+14674	PF14823	Sirohm_synth_C		Sirohaem biosynthesis protein C-terminal	Eberhardt R	re3	CATH:1kyq_A_03	Domain	This domain is the C-terminus of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241 [1].	24.00	24.00	24.00	24.00	23.30	23.90	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.26	0.72	-4.67	15	193	2012-04-25 14:50:59	2012-04-25 15:50:59	1	7	134	3	147	186	0	66.60	29	18.74	NEW	PcNhGsAl-sVGpLRp+LRc...lAPss..c-GsKRMcWMoplCEtaoL--Lsphs-pDh.-sLLsaahssplsohp	..........................thttAl.plG.LRttlRt.........hsss.........ppts.+..R.McW.................hsplC-hWsLcclspl..s-pDh..csLLphY.psp....p................	0	37	78	123
+14675	PF14824	Sirohm_synth_M		Sirohaem biosynthesis protein central	Eberhardt R	re3	CATH:1kyq_A_02	Domain	This is the central domain of a multifunctional enzyme which catalyses the biosynthesis of sirohaem. Both of the catalytic activities of this enzyme (precorrin-2 dehydrogenase EC:1.3.1.76) and sirohydrochlorin ferrochelatase (EC:4.99.1.4) are located in the N-terminal domain of this enzyme, Pfam:PF13241 [1].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	30	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.97	0.72	-7.03	0.72	-4.96	20	356	2012-04-25 15:03:26	2012-04-25 16:03:26	1	10	344	3	153	298	5	29.90	43	11.74	NEW	cs.usLQIMISTNGsuPRLuuLl+ccIcptl	.........G.LpIhVSTsGtSP+LAphIRccItsph.......	0	50	98	134
+14676	PF14825	DUF4483		Domain of unknown function (DUF4483)	Eberhardt R	re3	Jackhmmer:Q6ZQR2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 326 amino acids in length. There is a single completely conserved residue N that may be functionally important.	24.00	24.00	24.70	24.40	21.90	22.80	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.35	0.71	-4.65	27	116	2012-04-26 08:48:36	2012-04-26 09:48:36	1	10	64	0	94	109	0	165.70	23	57.40	NEW	shpsohtpNsLL.hKsclG+sppssasLPstc...asYGhhstt.pstGstEsh.pW.........ptptss.sppssp.........DFhphN+tAlppG.lsTA+.......-.htaRpp+s...l+hKs.t.....stptt.........ptssphssshs...aGhso+sso............PltpllptpYtppahpppttpptthppppp.........ttp.....lttT+AShh......++ht..spspp......aKMs+F.cpVss+lpo	............................................psclG+s+.psh..sLPs.s...asYGh..tt..stGs.-.........sh.pW.............................p.ht.p.st..th..........sahthN+tulptG.hhoup.................-.h.aRp.ps...l+hp.tp......tt.t...........................p.s.thssshs...aGh.s+sso..................shhpllptpYtp.ahppttt.t.ttht.pptpt.........................hhps+us.h..........................ppht...p.pt......a+h.+F.pph..th.............................................	0	65	74	81
+14677	PF14826	FACT-Spt16_Nlob		FACT complex subunit SPT16 N-terminal lobe domain	Coggill P	pcc	CATH:3biq_A_01	Domain	The FACT or facilitator of chromatin transcription complex binds to and alters the properties of nucleosomes. This family represents the N-terminal lobe of the NTD, or N-terminal domain, and acts as a protein-protein interaction domain presumably with partners outside of the FACT complex [1]. Knockout of the whole NTD domain, 1-450 residues in UniProt:P32558, in yeast serves to tender the cells sensitive to DNA replication stress but is not lethal. The C-terminal half of NTD is structurally similar to aminopeptidases, and the most highly conserved surface residues line a cleft equivalent to the aminopeptidase substrate-binding site, family peptidase_M24, Pfam:PF00557 [1].	27.00	27.00	27.50	35.30	23.20	26.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.01	0.71	-4.71	75	332	2012-04-26 15:17:54	2012-04-26 16:17:54	1	12	266	8	243	336	0	156.80	32	16.08	NEW	IDtssFtcRLptLaspWcpsppt.....hausssulllssGt.ss-..-stYpKosALphWLLGY.EFPcTlhlFs..pc..plhhlsSpKKAcaLcslp..p...........s..ssh.slclhsR..stpD...tpspp.Fpcll-tlc...p....sG.pp.lGslsK-..shpGpFh-pWpphhp....ppsh.cpVDlosul	................................lDtpsFhcRlpplaspWcpspp..........aus....ssul.llhsGt..sc-..-..YtKos........ALp..hWLhGY..EhscTlhlFs.....pc..plhhlsSpKKs..............caL....cplp..p.............sut.slpl..l..lRs.p-......pscp.Fccllctl+...p........sGpp.lGshsKD.....p.pGpFhcpWpchhp....ppsh..cplDloss.............................................	0	81	133	202
+14678	PF14827	Cache_3		Sensory domain of two-component sensor kinase	Coggill P	pcc	CATH:3by8_A_00, Pfam-B_120 (release 26.0)	Domain	Cache_3 is the periplasmic sensor domains of sensor histidine kinase of E. coli DcuS. This domain forms one of the components of the two-component signalling system that allows bacteria to adapt to changing environments. The ability of bacteria to monitor and adapt to their environment is crucial to their survival, and two-component signal transduction systems mediate most of these adaptive responses. One component is a histidine kinase sensor - this domain - most commonly part of a homodimeric transmembrane sensor protein, and the second component is a cytoplasmic response regulator. The two components interact in tandem through a phospho-transfer cascade [1].	25.50	25.50	25.50	25.50	25.40	25.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.50	0.71	-10.42	0.71	-4.19	258	2633	2012-10-01 23:40:40	2012-04-26 17:59:26	1	59	1299	16	414	1784	44	115.40	31	21.38	NEW	hslAcslApsPtlh..pu..lp..s.ssss...............................Qshscplppp.ssssFlVlhDhpGlRhoHP.sspp...IGcphh.....sD....ptAL.....pG.csasu.p.....spGoL..G.SlRuhsPlh...s..ss....G.cl.lGhVuVGhhhssl	.......................................shAchlAsssplh..pu..lp....p..ps.p...............tl........pshsp.plpc.p...ss..hsalV.lsDt.pul.Rh.sHP....ss..p+....IGpshp...s..sD........tAL....pG....c...p...hs.u..h.............................scG..ol.....G...ul.Rshs..PIh.........s...ps..............G...cl.IGVVulGh.lsp........................................	0	115	250	340
+14679	PF14828	Amnionless		Amnionless	Eberhardt R	re3	Jackhmmer:Q9BXJ7	Family	The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake [1].	26.90	26.90	27.00	26.90	26.00	26.80	hmmbuild  -o /dev/null HMM SEED	437	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.93	0.70	-12.78	0.70	-5.99	16	114	2012-04-27 08:29:45	2012-04-27 09:29:45	1	8	76	0	77	100	0	313.20	24	83.41	NEW	hKhWsssssFssAuNWss.sphPCupDhl.FPuphsssl.l.psh.olsshlLPpsGtllLApsu..hhhuusss.sssCts...ttpAhF+sPcpppWaDPss..Wpstsspsuh.........hss-hERVPCpp..........-cVlF..up.ushplsLp.ssphl+ltplphuGpoho+sp.LppaLuochGphhFH.supslpVp.h+....CspsptCsC...............spschh-hlCusl......pCst..spChsPlRP.GpCC.lCGAllplsps...sshDhcphps+lpcthhppshhp.plphtVuhVsppp.........hssplQllllD..pGs.otpuschhtp.hhtchpsphtshtt.shplptuGpPhssssuhs.............lsshlLhsLlLVullusllLh+h...........p.shls+lspWh+c.chhth.t....thspsFh.spFDsss...........ttsssltpls..............uhcutsspspc.psFsNPhF-p	................................................................+.a...shphpsstsW.p.tthPp.ts.l.Fst......h.l.l.....tsh..tltthhlP.hpGthllsptu...h.h.......s.s..tt....t...........t..h.h.....st....p....WhsPt.Wtstst...........................h..c.EplPCp...........-pVhh...sp.......sshtl..tlt...t.lpltpl.hh..s..pp..hstt..htth.hsp.p.....Gp...Fh...s...ttl.......lt..t.........phC.C...............s...t..........lCt.h.........pC.....stC.tslhP..GpCC.lC..Gu.hl.hpht....t.shpphpttl.phh.......t...tlththphh.p......................lp..hllhc.......tt..st.tht.ht.....tp.tt.h............hph..stt........h..................h..hh...hh.hhhhh.......hh.h........................................................................................................................................................................................................	0	29	34	59
+14680	PF14829	GPAT_N		Glycerol-3-phosphate acyltransferase N-terminal	Coggill P	pcc	CATH:1iuq_A_01	Domain	GPAT_N is the N-terminal domain of glycerol-3-phosphate acyltransferases, and it forms a four-helix bundle [1]. Glycerol-3-phosphate (1)-acyltransferase(G3PAT) catalyses the incorporation of an acyl group from either acyl-acyl carrier proteins or acyl-CoAs into the sn-1 position of glycerol 3-phosphate to yield 1-acylglycerol-3-phosphate. G3PATs can either be selective, preferentially using the unsaturated fatty acid, oleate (C18:1), as the acyl donor, or non-selective, using either oleate or the saturated fatty acid, palmitate (C16:0), at comparable rates. The differential substrate-specificity for saturated versus unsaturated fatty acids seen within this enzyme family has been implicated in the sensitivity of plants to chilling temperatures [2]. The exact function of this domain is not known. it lies upstream of family Acyltransferase, Pfam:PF01553.	25.00	25.00	26.00	48.40	21.00	19.90	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-9.34	0.72	-4.29	19	48	2012-04-27 10:01:24	2012-04-27 11:01:24	1	2	38	2	14	50	0	73.80	53	17.95	NEW	+S+oFLcscsEQ-LlSsI++ElEuG+LPsslAsGMEELYpNYKsAVlpSGsPpAcEIlLSNM.sshhDRlhLDVc-PF	........SRsFLcsRsEp-LLusI+KEsEuG+LPssVAsGMEELYtNYKsAVlpSGsPpAcEIlLSNM.sshhDRlhLDVc-PF......................	0	3	9	12
+14681	PF14830	Haemocyan_bet_s		Haemocyanin beta-sandwich	Eberhardt R	re3	CATH:1js8_B_02	Family	This antiparallel beta sandwich domain occurs in mollusc haemocyanins. Each mollusc haemocyanin contains several globular oxygen binding functional units. Each unit consists of an alpha-helical copper binding domain (Pfam:PF00264) and an antiparallel beta sandwich domain [1-2].	24.00	24.00	24.60	24.00	23.10	22.50	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.09	0.72	-4.32	27	179	2012-04-27 10:19:59	2012-04-27 11:19:59	1	15	36	7	0	211	0	99.90	40	24.82	NEW	R+p+DRVFAGFLLcGltsSAsVca.lCps..s....scC.pc..AGhFhlLGG-tEMPWuFDRLaKYDITcsLcphslc......hc-sFplclplsusNGotLsucll.sPollapP	.........ppc-RlFAuFLLpGItsSAsVph.lCts....s......spC..phAGpFhlLGGp.pEMPWsFDRlaKaDITcsLcclslp......hcssF......plclclhulsGotL.s.ssllPpPolla.P...........................................	0	0	0	0
+14682	PF14831	DUF4484		Domain of unknown function (DUF4484)	Coggill P	pcc	KOGs (KOG4704), PF09804	Domain	This domain is found, in a few members, a the the C-terminus of family Avl9, Pfam:PF09794. The function is not known.	25.60	25.60	27.00	26.20	18.40	25.40	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.43	0.71	-4.17	13	120	2012-04-27 10:43:25	2012-04-27 11:43:25	1	6	101	0	85	117	0	151.50	27	30.65	NEW	lEPlSWscLAYouFIWWASAGEpc.....cppE..ph-pDopLLAss-sssoP...................................sp.s...........pt.sElulVAYFHRLTsplFssLuDlIscpDsc.....ss.-s-......s........................-s.spD.................tD-s.uPL...................psp.slclTspDhs-MGLDsWSsuDh.FVcElVtpaWGR+AhV-uscIcsCGluIs	...............................................lEPlSWsthhasuFhWWASAGpph........t..p.tpDttlh.t............t.....................................................................................tpsph..tlsllsYF+RLToplhshltDlltppppp....p....t..................................................t.......................................................................ptt.lplsspshtpMsLDsaSttDt.FVc-ls.haa.tRp..h.lpshtlthsh..............	0	13	43	71
+14683	PF14832	Tautomerase_3		Putative oxalocrotonate tautomerase enzyme	Coggill P	pcc	CATH:3c6v_A_00	Domain	4-oxalocrotonate tautomerase enzyme is involved in the anthranilate synthase pathway.1	25.70	25.70	25.70	25.70	25.60	25.30	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.69	0.71	-4.16	26	117	2012-10-01 20:38:22	2012-04-27 13:13:24	1	3	81	22	87	147	121	130.80	28	84.02	NEW	MPLWpIaHPsssFo.s.p.-KpsLApsITchY........ssh.GLPsFYVsVhFhclsss...shalGGcspss.................FlRIslsH.IARp.........hssc..-p..ppchhp.tlstsLcPal...tD+.GhcWEaHl-EsspcLW+IsGlhPPsssStsE+cWsp-N+	............MPhaplaHs..ssho.s.ppKpplApsIT.p.hY........ssh..sl.PtFYVsVhFh..clsss....shalGGctpsp..................hlpl.hlpH..lu..Rp..........hpst..-t..ppphhp.tlsthl........t.shh........tpc...uhchp........hhls-sshphhh.sGhh.P..tptt...Wht.s.................................................................................	0	13	44	69
+14684	PF14833	NAD_binding_11		NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	Coggill P	pcc	CATH:2cvz_A_02	Domain	3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidized to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold [1].	30.00	30.00	30.30	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.37	0.71	-4.05	132	7339	2012-10-10 17:06:42	2012-04-27 14:05:12	1	47	2857	51	2191	5638	4290	121.10	28	40.35	NEW	GuGpssKhsNshlsAsslhAsuEAlshut+.sGlDspthhcll.su.usupS...ts....h....p......sh......hsphll....s....psF.ssG.FslsLhhKDlslAhsh..ucphsssh.Plsuh.sppla.p.s.u.t.s.p.hs..s.s.t.Daoul.l.+h.l	..................................GsGpssK..lsNphllusphtuhuEA.........hsLA.p+..sGl.c..pt...lh.cs.l........ss.....u...s...u.....s.S......hh.........h.....c..........sp............hst.h....hh...........s..........ps.a....s..P......u....F...t...l.....c...lhhK...D...........L.....slAlcs............Ac....p...hs...h..s.l..P..l.s.ut...s....p.pha.p.p.h...t...s...t...Gh...upt...DhSulhph...........................................	0	558	1233	1760
+14685	PF14834	GST_C_4		Glutathione S-transferase, C-terminal domain	Coggill P	pcc	CATRH:3bby_A_02	Domain	GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants.  Stringent starvation proteins in E. coli are also included in the alignment but are not known to have GST activity. The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain [1].	30.00	30.00	30.10	30.00	29.80	29.90	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.50	0.71	-4.16	7	561	2012-10-03 01:14:49	2012-04-27 14:19:54	1	4	556	1	52	223	10	116.50	75	54.87	NEW	DlQKRARARQlQAWLRSDLMPIRtERSTDVVFAGsKhuPLSpsGptSAcKLhAsApsLLuHGp.NLFGEWCIADTDLALMlNRLlLpGDcVPEtLsDYAoFQWQRASVQRalALSAK	...DLcpRARARQIQAWLRSDLMPIREERP....TDV..VFAGAKK.APL....os....cG.KASA...EK...L.FA...h...AE...+.L...L...u.h.GpsN...LFGEWCIADTDLALMINRLVLHGD-VPEpLsDYATFQWQRASVQRFIALSuK.................	0	5	15	38
+14686	PF14835	zf-RING_6		zf-RING of BARD1-type protein	Coggill P	pcc	CATH:1jm7_B_00	Domain	The RING domain of the breast and ovarian cancer tumour-suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. A dimer is formed between the RING domains of BRCA1 and BARD1. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level [1]. The corresponding BRCA1-RING domain is on family zf-C3HC4_2, Pfam:PF13923.	35.00	35.00	35.00	35.30	34.80	34.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.83	0.72	-9.37	0.72	-4.19	5	67	2012-10-03 15:03:13	2012-04-27 14:43:25	1	22	45	1	38	63	2	62.10	57	9.95	NEW	LDRLEKLLRCSRCTNILREPVCLGGCEHIFCSNCVSDCIGSGCPVCYTPAWIQDLKINRQLDSMI	....LtclEpLLRCS+CssI.LREPVCLGGCEHlFCSsCl..uD....ClG..o..s..CPVCaTPAWlQDlKINRQLDuMI............	0	5	8	18
+14687	PF14836	Ubiquitin_3		Ubiquitin-like domain	Eberhardt R	re3	Jackhmmer:Q6K1E7	Domain	This ubiquitin-like domain is found in several ubiquitin carboxyl-terminal hydrolases [1] and in gametogenetin-binding protein.	24.00	24.00	24.50	25.10	23.70	23.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-9.98	0.72	-4.32	6	283	2012-10-03 10:59:06	2012-04-27 15:38:54	1	13	52	9	133	242	1	86.40	46	9.70	NEW	uhKLClPGhssLpSPlpKtFRSoDTVGFlEuELKKLLul..Q+EoRLWKhsus-GhELLspP-lTlpEAGlh-..............GQpLLLEEhsEMGNWPP	......................-.hpLC.sss..hsssloppFS+sDTIs.sIE+EhRclFsIssEcE.T..RL..WsKh.hsN.oa..E.LscsDsTlpDAu...Lhp................................................G.Q.lL....VIE.+NcDGTWP.........	0	23	31	57
+14688	PF14837	INTS5_N		Integrator complex subunit 5 N-terminus	Eberhardt R	re3	Jackhmmer:Q6P9B9	Family	This family of proteins represents the N-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing [1].	27.00	27.00	27.20	27.50	25.00	26.20	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.38	0.70	-11.42	0.70	-4.92	17	78	2012-04-30 08:33:14	2012-04-30 09:33:14	1	5	69	0	57	82	0	214.30	46	23.26	NEW	tpslls-LptFlpsss...tp..shp......pLs+sALpLLcslPuuRsAVh-ahshlFccuVppahsshE...............t.ptstssss.-sslpElpssLpp.hlpssPpAWuslIssWulcLlGclus+hstRts.h.t...sls-hlphWhu.CpAh+pLlslhspClspllspss-sClssLLsouspHoPpFDWVVAHluosFPtsllo+lLssGlccFsst	....s.QpL.pElKsFlsulsshhupp.ssc......-hs+suLhLL+sLPsARsAVL-ahpsVF-EuVptalssl-.t..t................sscsssssssl--llpEVpplLpc.FlcsNP+AWAPlISsWS..l..........-LhGpLSSpYosR+t.hPpus.ulNElLQLWMu.CpATRoLM-lhspCLusLlsussDACV-ALLDTSVpHSPHFDWVVAHIGSsFPsTIIoRlLuCGLKDFss.p.	0	14	18	40
+14689	PF14838	INTS5_C		Integrator complex subunit 5 C-terminus	Eberhardt R	re3	Jackhmmer:Q6P9B9	Family	This family of proteins represents the C-terminus of subunit 5 of the integrator complex involved in snRNA transcription and processing [1].	27.00	27.00	28.70	27.30	23.70	23.20	hmmbuild  -o /dev/null HMM SEED	696	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.32	0.70	-13.19	0.70	-6.24	6	104	2012-04-30 08:33:54	2012-04-30 09:33:54	1	5	74	0	78	100	0	471.50	28	62.76	NEW	KlsSVVGILGHLAupHucsIRKtLLcMFptSLhst........ssshsus.pl++...ATVPFLLQLAuhSsTLLuAlSs-llchL+Pssl..Lsphtscapua.+p-h-shhsLsVHLl.psssGGA.+llphLlDTuossSslhstsssus.psl+EsCccLLQhLLh+LccLV+s+.............s..spsIPFL-ulpscluplssphLplccpRp.htpQLLsLLu.assPSlss-uhsaLLspApssEcLALhhpLhTp.ss.............shuGllshslcpsLupI......aspsls.p-htQLhpNLuphlp..aEcssphss....sh.uphlupAluuNLpshosLL.hps-sslucAhspLLuhhslPp.....sLSss.lLpLoRAsVpaFFhCLpppupstKs.........shpssspLLsRLsuh...SssupthsLppLlEsALa+usscLFGu..cpspcspppuhl........LL-pN++hsTolshstph.SVFHAGVIG+GhK.hhsspphs.-hVspNsppLlslIhpCCSssusss..............sp.ssIshEAsphVulhLVE.VsPDVhhstLsWPsEEauKsTlERDl+IRRpFcctPlLapLLclVAssRPALCYCSVLLRuLhATLlupWcoopc......ossS.hhLpsoshLVslMu.GQLLPPsLusl+-lhPpLsPFEVplLLhs.VWsYMR-NsP.PthFshsucpGhaaRDhoh-u..ssupYsssl+.VLp+NIcpL	......................................................................................................................................................................................................................................................................................................................................................................hh....u..ps..t.s.h.plht.......................................tp..h.p..................h...........hthh.Nl.hh.t...p.......................ht.th......l...h............hh........th.p.hspllt...hs........t....hL.ls...lphFF..hslp.ps..t...................tlL.c.sth...p..shhhsLp.llcsul...tt.thhGt....t......s.........................Ll..N.+......hstt..SVh.....HuGlI..G+......Gh+..............t...s.p.....p.t.hlphl.tCCts...t..t............................s..c..uhphlulhLV.E.l...ssD........s...h......stLsaP...sE-a...s+.s..ThERDltIt+tF.ppPlLatlLtllAtt.PA....LsYsSslLRuLhAshltpWcu...p..p...p......sst..ps....hh.soppLltlh.....u.upLlPPsLsphp.lh..htshElthlLhp.lWsah+...-psP..PthFh....stpu.hhhRshs.......tt......s..ahssl+.lhppplpp...........................................	0	26	33	57
+14690	PF14839	DOR		DOR family	Eberhardt R	re3	Jackhmmer:Q96A56	Family	This family of proteins regulate autophagy and gene transcription [1].	25.00	25.00	25.90	29.60	20.70	24.60	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-12.04	0.70	-4.59	12	132	2012-04-30 10:33:17	2012-04-30 11:33:17	1	3	62	0	75	135	0	175.90	37	79.55	NEW	ps-c--DtWllV-h.s....................................................................shsttssstpsP.....stsuhPss..........sh...................MEESWFVTPPPCFTAtG...ssstlEoSPhEsLLIEHPSMSVYsspssp.tsst..................cs...stsss.tsptppp...h.cps.spsAth.ss.puthLEpspphRtsQpspp+tE+ptLs+pslpRQNhsR-ppsRph+pp..ushlHQPs.Rp	...............................................p-.-.DtWhll-h.s................................................................................................................................h...s.sttss..........s.tshsss................ph........................M-ESWFlTPPsCFTAtG...ssh+lpoSPhEsLLIEHPSMSVYsstsohst.st..................................tsth....spt...c.p.psp.....hptp.t.......tthp.phsAsh.su.psshLcpspph....R....Qhh+p+sE+ptLs+pslpRQNhsR-pps+ps+pp..u.hhaQPs.p...................................................................................	0	11	18	37
+14691	PF14840	DNA_pol3_delt_C		Processivity clamp loader gamma complex DNA pol III C-term	Coggill P	pcc	CATH:1jr3_D_02	Family	This domain lies at the C-terminus of the delta subunit of the DNA polymerase III clamp loader gamma complex. Within the complex the several C-terminal domains, of gamma, delta and delta' form a helical scaffold, on which the rest of he subunits are hung. The gamma complex, an AAA+ ATPase, is the bacterial homologue of the eukaryotic replication factor C that loads the sliding clamp (beta, homologous to PCNA) onto DNA.	25.70	25.70	25.70	25.70	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.08	0.71	-10.72	0.71	-4.01	3	1110	2012-04-30 11:55:48	2012-04-30 12:55:48	1	2	1105	10	199	712	93	123.50	45	36.20	NEW	PFHWVDALLuGKSKRALHILQQLRLEGCEPVILLRTLQRELLLLVsLKRQSAHTPLRoLFDKHRVWQNRRsLLo-ALsRLStTQLRQAVTLLTRsELTLKQDYGQsVWAELEoLSLLLCHKALAD	.............PF+WlDALLhGK..upRAh+ILpQL+hEG.sE...PVIL.LRTLQREL..hlL.ls...L......+....+.........p.....p..u..........p.....s..........P.........L.c..s.L..F.D.+.a..R..VW.Q.NR.R.s.hhspA..LpRLo..s...pLp...pAlp...lLs+hE...lplK....p.sa.upslWs.pLcsLSLhhCt.........................................	0	36	94	149
+14692	PF14841	FliG_M		FliG middle domain	Eberhardt R	re3	CATH:1lkv_X_01	Family	This is the middle domain of the flagellar rotor protein FliG [1-2].	25.00	25.00	25.00	25.00	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.99	0.72	-9.33	0.72	-3.97	335	2392	2012-10-02 13:19:07	2012-04-30 15:19:29	1	7	2070	8	564	1518	436	79.20	35	23.40	NEW	-spplsshlpsEHPQslAllLuaL.csspAAplLutLPp.....c.hps-lhhRlAphcsl....sPcslcclccsLccclsuhsspptsp	......-PpplAslIpsEHPQhIAlILuaL.csspAAclLuhhs-.....c.h+t-VhhRIAshssl....pPssl.pElsclLpppLsu.stpp..p...................................	0	185	361	455
+14693	PF14842	FliG_N		FliG N-terminal domain	Eberhardt R	re3	Jackhmmer:O66891	Family	This is the N-terminal domain of the flagellar rotor protein FliG [1].	25.00	25.00	25.80	25.00	24.80	24.90	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.03	0.72	-3.94	137	2340	2012-10-02 13:19:07	2012-04-30 16:08:09	1	5	2032	4	556	1742	439	106.20	30	31.40	NEW	ttppLoGtpKAAILLluLGc-tuuplh+c.LspcElpplotphuplpplsppphcsVlcEFhp..hhhupshlshGuhcas+plLpcuLGs-+Appllpclt.tshpspsh-	...........h..ppLoGh-KuAILLh.olGE-tAAcV.h.+H.LspcE.....lpplottMApl....pplsp...c...p...l...p...s...V...Lp.E....Fhp.....h.p...p...p..ss...ls......hs..ut..-Yh..+...plLh..+ALG..p-+Assll-clh.tstp.....p.....................................	0	183	356	449
+14694	PF14843	GF_recep_IV		Growth factor receptor domain IV	Eberhardt R	re3	CATH:1m6b_A_04	Domain	This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.16	0.71	-12.29	0.71	-4.54	30	1237	2012-10-02 14:20:19	2012-05-01 10:27:03	1	65	119	40	458	1185	9	117.10	34	13.30	NEW	lCsshCossGCWGPGPsQCLSC+sasRs..........spCVpsCshhpG.sREats.sppChpCHsEC...ttt...tTCsGPGsDpCscCsHap.......D..GsaCVpcCPpGl..utpt..laKYuDtsshCc.CH.NC.opGCsGPs.psCh	...............................Ccs.Cs....s.u..CaGsssspC.l.sC...p....p.....a..p...h..t..........................ppCl..spCs..h...........s...tt...h......tt....pppChtCHPcC.............poC.sGs....Gu....D.pC...........h..........p.C..t....p....hp...............................-....s.pCVsp.CPps.......................................pY..s..s........ps.hCp.Cp..sC.....t..s..Ctt.......s................................................	0	183	209	322
+14695	PF14844	PH_BEACH		PH domain associated with Beige/BEACH	Eberhardt R	re3	CATH:1t77_A_01	Domain	This PH domain is found in proteins containing the Beige/BEACH domain (Pfam:PF02138), it immediately precedes the Beige/BEACH domain [1].	27.50	27.50	27.70	27.60	27.40	27.40	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.17	0.72	-4.20	47	917	2012-10-04 00:02:25	2012-05-01 14:40:39	1	50	255	6	593	862	7	103.80	25	4.48	NEW	pllhohpsphlsPhsshpGplplossclhFhss..........................ttppthhs.stshphcW.hsplcpla.hRRYhL+coALElFhsDposhhhsF..sppsppclhpplh	.....................................................................................................s.hltsh..h..h.GhL................ls..pp..p..hY.h.ss........................................................................t.t.t......hst.s..pthstp.Whhscl+pla.pRRaLLp.ssALEl.Fh....s..............s......t.....p.....s...h....h.l..sF..spps+pclhptl.h..................	0	218	303	448
+14696	PF14845	Glycohydro_20b2		beta-acetyl hexosaminidase like	Coggill P	pcc	PF02838	Domain	\N	27.00	27.00	27.00	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-11.26	0.71	-3.48	183	633	2012-10-01 20:56:08	2012-05-01 14:42:21	1	14	263	35	389	763	42	125.00	26	22.32	NEW	lW..PtPpt..hph......uspshtlsstshpht.tss...ttt......................................................plLppAhp.Rah...................phlh...............................................s.t.tshh.........................................................................hpt.............................................................................tl...ppl.................p...........lpl...ps.t.t.........l....phssDES............Y.sLpl.................phs.......spIpApohaGAh+G.LEThoQL	...........................................................................lWPhPpp..hph......usthhh.l.s...thphp.tsss..........................................................sppllppAhp.Rhh..............phlh..............................................................t..t.hhshh.........................................................h..tstt.............................................................................................tl....ppl.................p..lpl........ss.s..ts...........h....phssDES............YsLsl.......................sps..t...tsplpAposaGAl+G.LEThSQL..........................................	0	139	213	310
+14697	PF14846	DUF4485		Domain of unknown function (DUF4485)	Eberhardt R	re3	Jackhmmer:Q8N8E3	Family	This family is found in eukaryotes, and is approximately 90 amino acids in length.	24.00	24.00	26.40	24.50	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-9.81	0.72	-4.27	27	127	2012-05-01 14:06:49	2012-05-01 15:06:49	1	7	65	0	79	139	0	82.30	36	12.52	NEW	pLDppFphhlthlcshltpLs.ct.-+hhsstWlpKLpps.....psht.+cpRNtYhthLlttlp.psplp.sPFsc.PPsGsL.slsphh	.......................................................LDtEFcphlhphcshlhpLspcp.-+ppsshWlcKLspss...tsshht++sRNhYuclLLchLp.cGhL-.uPFscpP.sG.sLtsLspa............	0	37	42	59
+14698	PF14847	Ras_bdg_2		Ras-binding domain of Byr2	Coggill P	pcc	CATH:1k8r_B_00, Pfam-B_3317 (release 26.0)	Domain	This domain is the binding/interacting region of several protein kinases, such as the Schizosaccharomyces pombe Byr2. Byr2 is a Ser/Thr-specific protein kinase acting as mediator of signals for sexual differentiation in S. pombe by initiating a MAPK module, which is a highly conserved element in eukaryotes. Byr2 is activated by interacting with Ras, which then translocates the molecule to the plasma membrane. Ras proteins are key elements in intracellular signaling and are involved in a variety of vital processes such as DNA transcription, growth control, and differentiation. They function like molecular switches cycling between GTP-bound 'on' and GDP-bound 'off' states [1].	27.00	27.00	28.90	27.40	26.60	25.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.31	0.72	-4.11	35	148	2012-10-03 10:59:06	2012-05-01 16:35:46	1	5	140	2	96	150	0	108.10	33	12.03	NEW	pslphIhpsGpo+tVNlssChsupplhc+sLKKhulpp............p.psashalhss......................t.ssssh+hLsDsELlsICpu..ssRsE+pRLIL...sppsc..Pstctlpputplhh	.......llplIhssGsTKsVNlpsCpsu--lhcpsL+Khshpp................pp.psYshaVLsu......................pssssss+hLsDsELhpICcu..scRsERsRLIL.Rplpts-...Pstcplpputtlh.h................	0	24	53	83
+14699	PF14848	HU-DNA_bdg		DNA-binding domain	Coggill P	pcc	JCSG_Target_393235 / GS13689A, Pfam-B_2593 (release 26.0)	Domain	\N	30.00	30.00	30.00	30.10	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.02	0.71	-4.40	21	175	2012-10-02 15:10:05	2012-05-01 17:10:52	1	2	71	0	39	179	1	122.40	23	58.18	NEW	hLKhhLh-NhlT.-spsDahu.pltsssolslc-Il-chhKc.sosl+pETltpslplhpchls-hlhsGhuVNTGlhpssssl+GVaps.sspass....p+poltlshssuspL.RpslucspVphhs.t	........................phhLhcNh.hs....-stsch.hu.ps..pt.ssslslc-lsccltpc.sosl.ppt..slhsllshhpcpht-hlhsGhsV...p...h...G...lhphslpl..p..G.s.h.s......sssa..ss....php..pl...tVsassupcL.+ctltphth.....h.......................	0	16	36	39
+14700	PF14849	YidC_periplas		YidC periplasmic domain	Eberhardt R	re3	Jackhmmer:P25714	Domain	This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins [1,2].	24.00	24.00	24.10	24.00	23.90	23.40	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.91	0.70	-4.50	388	2338	2012-10-02 23:57:29	2012-05-02 08:46:08	1	6	2296	4	565	1722	2667	274.10	26	49.21	NEW	plslcTchlp.hsI.s....spGGclschpL....t..pY..tsh...........ssps........s...hpL....lsssst........ahuphGhh..s.........s.t.ss......ps...t.apsss...s.....ht.hp..........sphs..ls.Lshsss.s.G.l.....php+sashc.s...s........Yhlslphplp.N.pustslss..p.as..plpps............tt.........t....h.h.....sa.pGssh.............p............h..pchsa.....s-h.p.........................hp....tt.st......Wluhhp+YFsoAh.......l....P.p.........ss...shhsp.hh........................hhth..sh...................h..s..shslssG.sstsh..ssplasGPK...........chchL....................p.......t.........................l................s..........pL-hslD......aG.Wh........halu+PlFhl	.......................................................................................................................lslcT-slc.lsI.sspG.GclpphhL....h..pY...pph........................sssp.....................s.......hpL...lpsssth......................Y.ApsG.Lssts........s.ss........spsh.asspt.......s.sh...l..ptp.................................................sphp....Vs.hoasss..s....G..h........phpKsashccs.....s.....................YhlsVshplp.......N..s....u.......spslph.....ssas...plpps.......s.t...................tss....hsh....oa.pGssh.ssp...........pphpKhpa....cclpc..........................................tp.phssp..sG..........Wl.Ahhp+YFsoAa.......I....P.p.......................ss..p.ssh.hsp.phs........s.....................hhth..uh...........................p...s.....shsltsG...psssh..supLasGPc............pctl....................t......s...........l....ss..........pL-.h.s.VD....Y..G..Wh........hFIupPlFhl.....................................................................................	0	177	356	464
+14701	PF14850	Pro_dh-DNA_bdg		DNA-binding domain of Proline dehydrogenase	Coggill P	pcc	CATH:1k87_A_02	Domain	This domain lies at the N-terminus of bifunctional proline-dehydrogenases and is found to bind DNA.	27.00	27.00	30.40	29.10	22.00	20.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.16	0.71	-3.89	114	1463	2012-05-02 13:07:34	2012-05-02 14:07:34	1	7	1420	13	300	1184	316	113.30	63	9.56	NEW	uhl-uhLpEYuLSocEGlALMCLAEALLRlPDstTtDtLIcDKlusucWppHlG.pS.sShhVNAuTWGLhlTG+llsss.....c..pt...shsusLppllpRhGEPlIRpAlppAM+lMGcQF	...hVpuLLpEFSLSSQEGVALMCLAEALLRIPDpATR...DALIRDKISsG..sWpSHlG...pS...sSLFV.NAATWGLlhTGKLVusp........s.....-ssLSpuL..sRlIuKuGEPlIRKGVchAMRlMGcQF.............	0	58	149	224
+14702	PF14851	FAM176		FAM176 family	Eberhardt R	re3	Jackhmmer:Q9H8M9	Family	Members of the FAM176 family regulate autophagy and apoptosis [1-2].	25.00	25.00	25.00	25.30	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.39	0.71	-11.01	0.71	-4.53	13	190	2012-05-03 10:05:55	2012-05-03 11:05:55	1	8	53	0	110	149	0	132.10	37	48.52	NEW	-MsLLSNSlAAYAaI+sNPEphALYFVhGVChGLlLTLChLVlpISC...Rscs+t.psPc++ph+-ss..ss--ss-p--s-p--suDlcssc..............psph-tTL.ssNVFTSAEELERAQRLEERERIIREIWhNGQPDlh..GTtolGRha	..............h.ll.SN.LAuauaIp.spPEpsALYFVsGVChGLlLTLChL.VlRlSC....ppch+.....pts...p.cchh.tppp...psp.-ss....-..s.p.-t-.p.-.sss-.sh.t................pt.pts...shsVa.oShEthEhApRlEcREpIlpEIWhsut.Dh...hstshs.........................................	0	5	14	58
+14703	PF14852	Fis1_TPR_N		Fis1 N-terminal tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q9Y3D6	Domain	The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the N-terminal tetratricopeptide repeat [1-2]	25.00	25.00	25.00	25.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.08	0.72	-7.27	0.72	-4.65	63	299	2012-10-11 20:01:04	2012-05-03 11:57:25	1	4	237	10	204	283	0	34.80	37	21.62	NEW	tpopFpYAWuLl+SpttpDh.pcGltlLpplh+sss	....popFpYAWuLl+SptpsD..pcGltlLp-lh+ps.......	0	51	100	164
+14704	PF14853	Fis1_TPR_C		Fis1 C-terminal tetratricopeptide repeat	Eberhardt R	re3	Jackhmmer:Q9Y3D6	Domain	The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat [1-2]	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.93	0.72	-8.39	0.72	-4.08	60	363	2012-10-11 20:01:04	2012-05-03 11:58:45	1	12	284	10	239	400	24	52.10	39	30.22	NEW	R-tLYYLAlGpa+lt-YscA++alctLLchEPsNpQAtsLcphI-c+lp+.-GL	............R-hLYYLAlGp.Y+LscYscAc+Ys-tLLch.EPsN...pQAtsLcphI-cclpK-Gl...........	0	73	128	198
+14705	PF14854	LURAP		Leucine rich adaptor protein 	Eberhardt R	re3	Jackhmmer:Q96LR2	Family	This family of proteins activate the canonical NF-kappa-B pathway, promote proinflammatory cytokine production and promote the antigen presenting and priming functions of dendritic cells [1].	25.00	25.00	25.10	25.00	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.66	0.71	-4.40	7	138	2012-05-03 13:55:31	2012-05-03 14:55:31	1	3	62	0	88	131	0	103.30	40	36.75	NEW	psstsussppssspushctL-sKlhhL+.EMAaLRAlDVKlhQQLlslNEGIEulKWlhEE+uslTSRsSSLouS.YSLstup.soShRGSasSLpDss..DcLDuISlGSYLDTLA.D-lsE.s	...............tss...........ts.s.hpsL-splthLRpE.MssLRulDl+LLpQLhslNESIEul+WhlEE+usloSpsSSLouS.h.SLhtup..tpp.cGShs.......................................p...........................	0	12	18	43
+14706	PF14855	PapJ		Pilus-assembly fibrillin subunit, chaperone	Coggill P	pcc	Pfam-B_9717 (release 26.0)	Domain	PapJ is part of the Pap pilus assembly complex that plays an auxiliary role by ensuring the proper integration of PapA into the fimbrial shaft. PapA is the major shaft protein of the pilus.	25.00	25.00	50.30	50.10	19.60	19.00	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.10	0.71	-4.82	3	54	2012-05-03 16:50:17	2012-05-03 17:50:17	1	1	37	0	1	26	0	178.40	63	99.69	NEW	M..NRTTsGLYLAALLlSuSMsoVLQA-ELllRDDFFVADEsRHQWVNE+NGRTGoLNVKGALVSSPCIL-TPEVsLPLpcDNG+YV....LNLKLS+CGDGtS-lPE+cussphNlsVKQSlVLKcGcsslLLS-+KsuGpsRcll+cGDNQLlYhlN+cQYEKIAcsQpcsTt+.chSDu+os..sL+LsIhYE	MVV.NKTTAVLYLIALSLSGFIHTFLRAEERGIYDDVFTADE.+HYRINE+GGRTGoLsVSGALLSSPCTLsoNEVsLSLR.-N+....shu....LhL+LuGCGDGGAl.Pu+cuss...MsVsuSlVhusGpsusLLP-+KhuGscHhVl+DGDs.Llhhss+cQp-hLAuhppcsTtc.tcYSD..u+os..hLRLsIcYE............	0	0	0	0
+14707	PF14856	Hce2	Ecp2;	Pathogen effector; putative necrosis-inducing factor	Stergiopoulos I, Coggill P	pcc	[1]	Family	The domain corresponds to the mature part of the Ecp2 effector protein from the tomato pathogen Cladopsorium fulvum. Effectors are low molecular weight proteins that are secreted by bacteria, oomycetes and fungi to manipulate their hosts and adapt to their environment. Ecp2 is a 165 amino acid secreted protein that was originally identified as a virulence factor in C. fulvum, since disruption reduces virulence of the fungus on tomato plants. We have recently determined that Ecp2 is a member of a novel, widely distributed and highly diversified within the fungal kingdom multigene superfamily, which we have designated Hce2, for Homologs of C. fulvum Ecp2 effector. Although Ecp2 is present in most organisms as a small secreted protein, the mature part of this protein can be found fused to other protein domains, including the fungal Glycoside Hydrolase family 18, Glyco_hydro_18 Pfam:PF00704 and other, unknown, protein domains. The intrinsic function of Ecp2 remains unknown but it is postulated by [3] that it is a necrosis-inducing factor in plants that serves pathogenicity on the host.	25.00	25.00	25.60	25.10	24.80	23.80	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.82	0.72	-10.54	0.72	-4.08	39	124	2012-05-04 15:03:41	2012-05-04 16:03:41	1	6	44	0	97	117	0	102.60	27	20.68	NEW	spCss.So.ap.spTss.sSP..hssDCtplhpslt..ps.....G....p.W..s..lt.....s.tsp.........+plsphGoCsFGlps......h.p..ush...th.t...lGspDlhDllps..uIs..pau......ps......G+..VGApGphpC	................Css..oo..ah..spTos..uSP...hssDCttlhpslt..ss...........G....p.Wpht...........s..ssp...............pplsphG.....oCsFGlps................tp...ssh.....th.tlGspDlhcllpp..ulp..pas................ts.......G+..VGupGphpC....................	0	17	47	73
+14708	PF14857	TMEM151		TMEM151 family	Eberhardt R	re3	Jackhmmer:Q8N4L1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 338 and 558 amino acids in length.	27.00	27.00	28.90	33.20	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.62	0.70	-5.88	9	144	2012-05-08 07:39:01	2012-05-08 08:39:01	1	4	59	0	100	128	0	347.60	50	78.89	NEW	QRPlKQSLotSLCRESHWKCLLLSLLMYuChGsluWCpLspVT+Luhss.......u.....apGpS..hlYH......DSPCSsGYlYIPLAFLsMLYlVYLVECWHCas+sphthKs-lsoVhERlpRhQQAsPCIWWKAISYHYVRRTRQVTRYRNGDAYTTTQVYHERVNTHsAcuEFDYupCGVKDVSKpLhGL-sassTRLRFTKCFSFAsscuEsuYLTQRARFFs-NEGLDDYMEAREGMHLKNVDF+EahlAFsDPs+.PWYspphsFWhAuhhhLSWPLRVlsEYRTAaVHYHVEKLFG.......h-hs........u.oPss....sshtttlsRVsTlDoTELEWHIRoNQQ.LVPSYSEAlLMshuptsstsstos..........................psYut...........hhpsC-RCpR..........osSSSSl..................hSRsuht.s..s....ssRLu........husS+FSLGRlaGSRpo..sLaRSRS	.............................................................................................QRPlp.ShstSLCRESH.WKCLLLoLLhauC.huslsWCplspVs+Lshss...............u..ht.Gps..hh.Y.......sSP.CSsGYlYIPLAFlhhLYllYLs..ECWHC.psRppht.h+s.DspoVhphlpRhQQAsPCIWWKAlSYHYVRRTRQVTRY..RNGDAYTTT..QVYHERVNTHsAcuEFDY.....uppG.V+DVS.....K.p......LlGLptt..ssTRLRFTKCFS....FussEuEsuYLsQRARFFs-N.......EGLDDYMEAREGM+LK.s.V.DF+E..hls.as.DPtp..PW.YspthsFWhsuhhhLSWPLRVlscYpTAasHYpVEKLFG.....................................................s.ssst.......s.t..l....sRVsTlD..T.E...LEWH....Ip..sNpQ.lVPSY..SEAhlMshst........................................................h..h..p..ssppC.....p+..........s.opsuh.....................tt.t.....................................................................................................................	0	23	34	67
+14709	PF14858	DUF4486		Domain of unknown function (DUF4486)	Eberhardt R	re3	Jackhmmer:Q96N23	Family	This domain family is found in eukaryotes, and is typically between 542 and 565 amino acids in length.	25.00	25.00	25.50	25.50	21.80	21.80	hmmbuild  -o /dev/null HMM SEED	542	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.06	0.70	-12.84	0.70	-6.25	5	92	2012-05-08 08:35:29	2012-05-08 09:35:29	1	4	58	0	60	81	1	326.70	35	26.02	NEW	pcaEh+RRGAsTLFNIWsKYcPRLPssYYNEKLLKVGDSLsQIK.................EYKLALhQCYGRYLQQFso.NsDEspsD..lspFKssFFPcGFcDcTAtLTFHALpG+NlCsYQLVC-SDsNLQNcESVppCL+ILSSLRLIMQAALPQEsLCWIIFNGTlHIYoICR+LMsIGQSSKVLEYLLWASMCMESSVPLLSlRYLTWRATLYsAVCQCYYDC+AGIHGEuFARRALuKINEL+QLEpMSSScuopEop+hFREATIKMAVMIFKRuVFESRRKPKulFRPKlRlNLKEsQsLPWPRTsTERLLsEhFDGTASQFLAVLEALSDSNRRlLQTGP.VoD.EsEI+DVVSELFhAGhE.L...LIhuNl+ss.............upLDFPpoSLLEpllsc+NsISV-AAVKFlKLAFoYEEWulF-SLustLlpFLQpQ-DPpuKKAEK-LcLLtAlEPLlss+Rs+.Ghhlsp-s-K-uQospsaLKHhss+psphhssta....oEDlFpLAsTLHsCVCsssQsI..pPDKDIVlDllhFLWQKCKlGlQRlsIs+h-ssKYspKhu	.............................................................................................hl.hu-.h....t...........................................................................h....h..hpsh.....s.hth.htts..h.p...sh..hh....p....hLt.....hRhhhphsl.s.t.-.....phhWllaNGolhlYplCcpLh..hh..G......oscslthl.hh.s..hshE........l.L.s.+YL.WRhpLhshlstsh.c.....t.h...pu.hhAp+ul.+lp-L.pLE.hs......t.tt.hh.s................................................................................................................................................................................................................................................................................................................................................................................................................................................................p..........................................................	0	23	31	41
+14710	PF14859	Colicin_M		Colicin M	Eberhardt R	re3	Jackhmmer:P05820	Family	Colicin M is a toxin produced by, and active against, Escherichia coli. It catalyses the hydrolysis of lipid I and lipid II peptidoglycan intermediates, therefore inhibiting peptidoglycan biosynthesis and leading to lysis of the bacterial cells [1].	27.00	27.00	32.20	38.40	24.40	24.30	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.77	0.70	-5.51	2	47	2012-05-08 11:57:22	2012-05-08 12:57:22	1	2	30	16	4	47	0	223.20	56	87.11	NEW	phpl....PuT.l.s.t.Gs.p.ou.pVPusGsllsphV......Yuhhp.ssMh.ptLpthcs.h.taGhss.....hI.sslthhpsADh.LlhpPtlSshDAap..hpcsu..Q.shp.hs.pphSGsshTPhhAltHaLhGNGsptSVpIupIGlp.oP.KIsplhsIIpouhlGphsVshphoahTGp.sVIsthYLGsITLphpGplThsssGohoasGVV+uasD+YDhNASoHRsshsEuhT....clGthhsuK-YtI.lsGEl.I..ShtR	.....................................................................s.....................................................MslpsLptlcDalcpHGhss.....hI.sslthhpsADh.LlhpPtlSshDAap..htcsu..p.shpphsh+phSGNVhTPIsALAHYLaGNGA-RSVNIuNIGLKISPhKIsQIpDIIcS..Gs.V..GTFPV...Soc..Fo...+AT.....Gc...hsVI...o...uuYLGNITL+TcGTLTISAsGoWTYsGVVRSYDDKYDFNASTHRGlIGESLT....RLGAMFS.GKEYQIllPGEIcIp.SGKR................	0	0	0	2
+14711	PF14860	DrrA_P4M		DrrA phosphatidylinositol 4-phosphate binding domain	Eberhardt R	re3	Jackhmmer:Q29ST3	Domain	This domain binds to phosphatidylinositol 4-phosphate. It is found in Legionella pneumophila DrrA, a protein involved in the redirection of endoplasmic reticulum-derived vesicles to the Legionella-containing vacuoles [1,2].	27.00	27.00	49.40	49.30	25.80	18.80	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.55	0.71	-4.36	3	23	2012-05-09 07:41:44	2012-05-09 08:41:44	1	1	8	9	3	20	0	112.70	42	28.65	NEW	cNLcEsl..KhupccKhtuRpHcaTA...s+psspshKE+YpQlKGDuLK+sILs-LKDcLAEIcsh-sLK-hltEFKuSsEYpILAKGQGLTTKlLGLKTSSp+uVEcIFcEAcEcIpSscp	............pshc.sl..c...stKhtuR.Hhass...s+hhs.phpEpYptlKGDhLK+sILp-LKssLtcIssh-pLc-hhtEFKsSsEYpILucGQGLhT+shsLKTSSh+ulpchhcEscccIpsp.....	0	3	3	3
+14712	PF14861	Antimicrobial21		Plant antimicrobial peptide	Eberhardt R	re3	Jackhmmer:P86698	Domain	This family includes plant antimicrobial peptides [1-2]. They adopt an alpha-helical hairpin fold stabilised by two disulphide bonds [2].	27.00	27.00	36.50	30.10	24.90	21.20	hmmbuild  -o /dev/null HMM SEED	31	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.67	0.72	-7.86	0.72	-4.47	22	86	2012-05-09 09:58:20	2012-05-09 10:58:20	1	7	8	0	22	72	0	31.30	45	52.48	NEW	spspccCc+pC.pHHp..D.hc+QpClpcCcp+c	..scupccCR+pC.pHH+..D.W++QpChp-C+p++.	0	0	8	15
+14713	PF14862	Defensin_big		Big defensin	Eberhardt R	re3	Jackhmmer:Q0H293	Family	Big defensins are antimicrobial peptides. They consist of a hydrophobic N-terminal half, which is active against Gram-positive bacteria, and a cationic C-terminal half, which is active against Gram-negative bacteria. The C-terminal half adopts a beta-defensin-like structure [1,2].	25.00	25.00	25.00	25.00	24.60	24.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.30	0.72	-9.97	0.72	-3.91	4	41	2012-10-01 20:50:19	2012-05-09 13:58:57	1	1	10	2	2	47	0	78.80	58	67.17	NEW	AIPllYhGAsVuPsVWsWLVshhGAAAVsAAulp.......puSsDsHSCAsNRGWCRSpC..FpHEYlDsapSuVCGpYcCCRs	.................Ll..PlA.YAGhTVSsPVFAALVusYGsYAVhRYsIR....................pusp..DSHSCANNRGWCRsoC..FSHEYpDWaN.ssVCGSYcCCRP.............	0	1	1	2
+14714	PF14863	Alkyl_sulf_dimr		Alkyl sulfatase dimerisation	Eberhardt R	re3	Jackhmmer:Q9I5I9	Domain	This domain is found in alkyl sulfatases such as the Pseudomonas aeruginosa SDS hydrolase (Swiss:Q9I5I9), where it acts as a dimerisation domain [1]	26.00	26.00	26.00	26.80	25.90	24.80	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.37	0.71	-3.95	196	988	2012-10-11 20:01:04	2012-05-10 11:46:15	1	8	790	10	240	798	507	139.00	47	22.62	NEW	hTssEIA.-plp.LPssLsp.paasRuYYGolsHNs+AlYptYhG.WaDGNPAsLpsLsPt-pAc+YVchh..GGs-pllppAcp...saspG-..........YRWuAplls+lVa.............A-PsNp.p.........ARpLhAc........sh-QLGYpuEsusWRNhYLoGAhELRsGs	........................hThsEIu-hl+..LPsuLsp.sWtsRGYYGSlSHNs+AVYphYLG.aaDGN.P.AsLpPhsss-huc+YVphh..GGu...spVlphApc...uhcpG-..........YRW....uAcllcpllh.............AsP.ssp.s.........A+sLpAs........shEQLGYQAESu.sWRsaYLoGApELRpG.l........................................	0	55	123	185
+14715	PF14864	Alkyl_sulf_C		Alkyl sulfatase C-terminal	Eberhardt R	re3	Jackhmmer:Q9I5I9	Domain	This domain is found at the C-terminus of alkyl sulfatases. Together with the N-terminal catalytic domain, this domain forms a hydrophobic chute and may recruit hydrophobic substrates [1].	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.44	0.71	-4.14	140	895	2012-10-02 14:08:01	2012-05-10 11:49:45	1	6	760	10	211	992	282	122.00	34	19.64	NEW	sssos-hltshssc.hhDhlAl+lsus+At.......st.clslshhhs.....Dh.s.....c...........patlplpNuVLst....hpstp.......ssA-sTlol.s+ssLhslh.hstsshsphhtsspl...pl.pGDtstlppLhuhLDph-.....stFsIVsP	.....................................................s.suSsDslpuMos-hlFDahu..VRL..s.usKAs..........Gp..slslNashs.....-...s.....-................shpLpLpN.uVLsa........pcshp.......spADsoltl.sRpsLpsll..h....G...psphsphlp.u...tcs..+l...tG.ssstLpclluhLDsFD.....hhFNIVTP...............................	0	53	111	163
+14716	PF14865	Macin		Macin	Eberhardt R	re3	Jackhmmer:B3RFR8	Domain	The macins are antimicrobial proteins [1-3]. They form a disulphide-stabilised alpha-beta motif [3].	27.00	27.00	28.00	34.10	25.00	18.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.09	0.72	-9.69	0.72	-3.87	6	15	2012-05-10 12:11:02	2012-05-10 13:11:02	1	1	8	2	2	17	0	57.30	45	63.35	NEW	sCa-sWSRCoshoSthTGlLW+oCs-pCK.cLG+psGpCh.sPS.sCP..sch.pshQCpCa	sCa-sWSRCothoushTGILWcoCssRCK.ChG+ssGsChpsPS.sCsh.pc..csaQCpCh....	0	2	2	2
+14717	PF14866	Toxin_38		Potassium channel toxin	Eberhardt R	re3	Jackhmmer:Q9NJC6	Family	This family includes scorpion potassium channel toxins [1-2].	27.00	27.00	27.00	27.00	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	57	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.90	0.72	-9.51	0.72	-3.88	13	40	2012-10-01 23:31:40	2012-05-11 08:49:57	1	1	17	0	0	57	0	56.80	41	66.59	NEW	splKstLpplhcKlht....l.upSpaGCPs...I-paC-DHCps.c+t.GpC-shcCpChp..u	.................s.pl+phlpsVlHKl........uKopauCPs...hpsaC-cHCps.c+ccGhCHG...h...K..CKCsh..s...	0	0	0	0
+14718	PF14867	Lantibiotic_a		Lantibiotic alpha	Eberhardt R	re3	Jackhmmer:P86475	Family	Lantibiotics are two-component lanthionine-containing peptide antibiotics active on Gram-positive bacteria [1-2].	27.00	27.00	37.50	36.90	25.20	24.40	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.50	0.72	-7.73	0.72	-4.70	14	26	2012-05-11 09:53:12	2012-05-11 10:53:12	1	1	26	1	4	22	0	31.70	45	48.22	NEW	ssssssshslShsLGNcGthCThThEC.ssCp	.h.sshsphhhlSpsLGNcGtlCThThEC.ssCp.	0	2	2	4
+14719	PF14868	DUF4487		Domain of unknown function (DUF4487)	Eberhardt R	re3	Jackhmmer:Q9NSG2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 209 and 938 amino acids in length. There is a conserved WCF sequence motif. There is a single completely conserved residue W that may be functionally important.	25.00	25.00	31.00	25.90	21.80	23.80	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.86	0.70	-5.80	12	134	2012-05-14 11:54:13	2012-05-14 12:54:13	1	2	71	0	67	136	0	387.30	29	64.66	NEW	hslhssoWKhlIp....pt+sslcsplphp...-IlssLhpslh.Sh+sshp.........hhpsshp-...shshp.hp+shh.s+FahsslV+hspta.s.h.tsspplhpLhl.l.hSpFh.uLpttplscstpE.luphh.hshssLlspLLsts.....hhpphhtphLs.......hssc..p.....hsp.shhhh.s.hD+lso.s.plhslassss...tphpcl.lhp..slFtshhpsSsElp.sspLt..............................Gs.upupt..lh.olYptlhhpLpsah..ss.hsss.tascLEthLLpslLpsphlst.lsh-lWCFlu.Rausu-LssphlshlspLlKsh........P........usshphhs..LshL..LpR....hhh.hssphpsphlpphpsp...psps..........hhlhcthsL..puLssp....l+p...pstcplhsshhu.hhppa.p..........sosohGtlt..stsLSusLtsppsussslDt+plsslltllsphhshl..cpltsc..h.pphhshhLslluhh.hphhpsphlppllptL.psLhhppsssp......l+hs...hhpFluuLGch.hsps.psthsstl.....pLaphLLp-cpWhlhphAlpAFshFApcTspppl	........................................................................................hhhp..........h.....h.....h....h......h....................tt......t.t.h.hhhh.h+ahh..hhph.t.a...s.h.t.h.tp.htLhl.h.tS...tF..SL.ttphsKutpE.hsshh.hshssLlstL.Lsht.....hhp.lh.sh.L-........h.sE..p....hs...hh.h...hDphspts...h.slhshss...pptspl.Lhp..hlF.sh.phSsELp.sspLt..............................t..sputt..h..shaptlh.tLpshh..h...h.ss.ha.tl-hhLLpshht..p..s..l..-hWsFhh.+..............hup.phs....hh..lh..lht.h........s...............t......h.......ht.h..ltp....h....h.................................hht..........................h..h....t.h........t........th..................................h.........................................................................................................................................................................................................................................	0	18	30	46
+14720	PF14869	DUF4488		Domain of unknown function (DUF4488)	Coggill P	pcc	Pfam_7936 (release 26.0)	Family	In most members this family covers almost the whole sequence, but a few member-sequences also carry a TonB_C domain, PF03544.	25.10	25.10	25.10	36.00	24.70	23.60	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.51	0.71	-10.68	0.71	-4.59	11	63	2012-05-15 08:09:31	2012-05-15 09:09:31	1	4	49	0	9	41	0	130.40	55	67.57	NEW	psLpGVWQhCh.hspss-lsucLcsuss.LKlLS-DspFhNlhh...hs.suAIIhupGpYch.SDs.......sYsEplEK.slaLshlsGp-N.lphEhhc.....DsLhhl+ahlsschs....spWhpEhW+RV..PshhP.s...hsc	.....u.sLcGIWQLCaYVS-sP-lPGtLKPSNo.FKVLSDDGphlNhTh...hPsus.AIITGYGTYcQhoDs.......oYpEsIEK.NIHLPhLcspDNlLcFEht-.....ssll+LKYFlcsDhNGNElNsWaaETWKRVpMPshaPcDlVR......	0	2	8	9
+14721	PF14870	PSII_BNR	PSII_YCF48;	Photosynthesis system II assembly factor YCF48	Coggill P	pcc	Pfam-B_547 (release 26.0)	Domain	YCF48 is one of several assembly factors of the photosynthesis system II. The photosynthesis system II occurs in Cyanobacteria that are Gram-negative bacteria performing oxygenic photosynthesis. One of the three membranes surrounding these bacteria is the inner thylakoid membrane (TM) system that is localised within the cell and houses the large pigment-protein complexes of the photosynthetic electron transfer chain, i.e. Photosystem (PS) II, PSI, the cytochrome b6f complex, and the ATP synthase. YCF48 is necessary for efficient assembly and repair of the PSII [1]. YCF48 is found predominantly in the thykaloid membrane [2]. It is a BNR repeat protein.	27.00	26.00	27.00	26.00	26.90	25.90	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.71	0.70	-12.09	0.70	-5.43	23	762	2012-10-02 00:45:24	2012-05-15 10:59:18	1	27	377	1	329	819	370	140.60	23	53.77	NEW	hsshsssPWchlpLso-s..slLDluFs..sspHGaLVGoptolLETsDGGcoWctRs...LDls--.saRhpSVSFsGsEGWIlGcPulLLHTsDGGcoWoRlsLSsKLPGsPhhIsALGss.sAEMsTss...GAIYcTpDuGpsWcAtVpEsl...................GslRslpRus-GcYlAVSSRGNFYuTWpPGQshWpPHsRsSSRRlQsMGFs.c...GpLWhlsRGGplpFos....sss.-sWsc..........shhPlhosGaGlLDLAa+ss.s-lWsuGGuGoLlsSpDGGcoWp+Dpss-slPoNhY+IhFhss.....spGFlLGpcGlLLRYs	.................................................s.....................h..pt......lhs.lhFh..stp..pGas.......V....G...p.........t.......u.....h...l.....LpTs.DGGpoWp..ttt................s....h....t...p................................h......s..l...t....h......s.p..p.....s..a..h.....s.......G.........p.........u....h........lh+..op.D.sGtsWpt........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	128	201	276
+14722	PF14871	GHL6		Hypothetical glycosyl hydrolase 6	Coggill P	pcc	Naumoff D [3]	Family	GHL6 is a family of hypothetical glycoside hydrolases.	35.00	35.00	35.10	35.00	34.90	34.90	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.48	0.71	-10.66	0.71	-4.13	13	111	2012-10-03 05:44:19	2012-05-15 14:59:04	1	3	70	0	59	240	54	134.20	26	19.46	NEW	Dscphscth+ch+usolslFupstaG.hsaYsop.l....ts..c..HPtL..p.t....DlLtEtlcAs+ccGl+Vslhhshs.hccplhppHP-WthhstsGt.........stthstst.a.p...lChNSsYh..-.ahttpl.cEslc...th..slDGlFhDh	............................................................tphhphlcpuplsulsl.upsttG.huYYPoc..l...............tp..h.......pPtL.....p..p.....................Dllu-hlcAs+ctGl+lhs..h.h........sh.....s.....h....-...p......p..............h.h.........c.pHP-Wh...hh....stsGp...................tphhpss...aht..........hCh.N.u.s.Yh..-..alhppl.cEllp...pY...ssDGlFhDh...........................................................	0	36	52	54
+14723	PF14872	GHL5		Hypothetical glycoside hydrolase 5	Coggill P	pcc	Naumoff D [3]	Family	GHL5 is a family of hypothetical glycoside hydrolases.	23.70	23.70	26.50	24.60	22.80	22.20	hmmbuild  -o /dev/null HMM SEED	811	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.45	0.70	-13.45	0.70	-6.77	10	27	2012-10-03 05:44:19	2012-05-15 15:19:15	1	1	22	0	6	24	9	739.50	52	96.71	NEW	ppLL-WAssI-p.S-sThFEKAQplAsRLGAHYRs.DGLTEIGFWTPELuu-lIQs.+sIaLEVFTPl-sIDhpts-QslpF+RDplpLc+QGEYtWGVVuGL+AGTR-QhGSFYWLRYlD.p.sclpsIRDsLAYSLPYGVFAPAELYDhcsLQccRADLsYFcppuup.............p..s.....sss..........lsRVPAPpNILQLHVsTASPsGTLuGLTclYQRIucKLusupPLTPAEpNYlGYDAVQLLPIEPTlEYR.sE.pss.cHcFFslcs.........c-.sphss.s..l..pstcl.....clsL+KP-TQNWGYDVsIlGSuATNPAlLpTLRPDElVDFIATLHNFsTGPIQlIYDLVYGHADNQul-LLNspFLKGPNMYGQDlNHQsPsVRAILLEMQRRKlNTGADGIRIDGGQDF+FFNPLoGcVEYDDsYLLAMuDlVQ-IGstpRhLFTIFEDGRPWPsEGWEEISTYRDLIEL+P-SFQWGPLIFAHNTPsLpGFWD+KWRRVCEVMhpG-+WITGCGNHDTVRRGNQlssst.sINWpLGsTLPEVLpNAYDNPAlsLWVYGFuPGLPMDFINusMRAPWGFFRNTDDRYGVKVVAEEh.GFLDWQloPElYppsp.lFs+LKpLGFo-L-tLRQFh+ALppAht-oDYDL-cVAphCQpslGssst.p-.............Lpclshs-tssFLssLDVuKLKpFAhAFMEDsH-hCNVp+apDpl-ssQsuFNLALRcFR+u+PWL+cNLs..s.s.DRFN+Io-cppTlFYGlRssPh-t-......sptpspplAMVAHMGGEPhTVsLG-WLpLDLscWplAIASPGLc....l....c...D....L+u..FEL+DSQulLLE	.............................t.pLhsWAtslpp.SstshFptApplAp+LGAHaps.DGLTplGFWTPcLsup.hhpp.tpIaLEVaTPhptIDhpusp.QslhF+R-hlpLtppGEahWuVluGh+sGoR-phGSFYWLRYhD.t.sphphItDPLuYSLPYGVFAPAElYDlcphQtpRsDhsYhcppss......................................p.........t...............ls+lssPtNILQlHlsTAospGTLsGLTclYpRlucKlhpt.sLoPsEpNYlGYDAlQLLPlEPTlEYR.hc..p..tptFFshts.........c-...............tpl.....plpLpKPcTQNWGYDlsIh....GSuATNPulLtThRPDElVDhIATLHNFPsGPIplIYDlVYGHA...DNQu.hpLLNtpahK....GP..N..MYGQDLNHQ.PhVRAILLEMQRRKh.NoGsDGIRlD..GuQDF+aFNPloscVE.DDsYLhtMuDlVQ-IusscRhhFsIFEDGRPWPp-GWE-hSTYR-LI-hc....P-uaQWGPLIFAHNTPsLpuFWp+KWcRVCEVhhpG-pWITGCuNHDTlRRGsQls.p.....t.pINhpLGsTLsEVLpNAYDNPAstLhsYGFsPGLPMDFlNAhh+APWGFhRNTD-RYGVKVsuEEs.GFLDWQlsPEhYptst.hFspLKtLGFpcLt.LppFhcuLtpAhhpsDYsLptlAchCptshs.pst.pt.............hpphthsp.sthlppLsVsKLKpFAcAFMEDsHEhCsVSpat-pl-stpssaNLtLRpaR+s+PWL+cNLt..ss.D+.Fs.pIps.sspTlFYGlRssP.ptc......s...stpVshVsHM.tG.-PhpVslGDWLpLDl..s..cWplAIAoPGlp....l....-...s....Lps..FEL+DuQullL..............	0	1	5	6
+14724	PF14873	BNR_assoc_N		N-terminal domain of BNR-repeat neuraminidase	Coggill P	pcc	Pfam-B_13890 (release 26.0)	Domain	This domain is usually found at the N-terminus of the BNR-repeat neuraminidase protein family.	25.00	25.00	25.60	25.80	22.30	23.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.24	0.71	-4.41	37	147	2012-05-15 14:59:52	2012-05-15 15:59:52	1	11	89	0	21	137	9	139.20	24	23.46	NEW	tus-s....lhlcpsplPlLlc+psNslhhlRlpsppspt...LsclsLshstsssLsDIpul+LYhuGo.cuhpcps+thhtPlshh..........................spplsLp.....us.pLh.sGsNaFWlSlphK.sssoLts+lssphsplphsspph	......................tp.....lhlcpsplP.lL.lc+psNslhtl+lpsppsps...LsclsLshstssslsDIpulcLYhuGs..cuhpsps....+hhhss.lsh...........................spplsLp.....sp.pLh.sGsNaFWlolph+.ssssLts+lssslsplphsspt.h..............	0	6	16	21
+14725	PF14874	PapD-like		Flagellar-associated PapD-like	Coggill P	pcc	Pfam-B_1987 (release 26.0)	Domain	This domain is a putative PapD periplasmic pilus chaperone protein family.	27.00	9.40	27.00	9.40	26.90	9.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.40	0.72	-4.07	5	621	2012-05-15 15:06:52	2012-05-15 16:06:52	1	29	105	0	426	554	6	86.70	17	7.00	NEW	sPpLEVpPspVcFGpVlPGpRYltTVcLTNsSTVPCRYRVRlssss+shLpVpYs+QFVAPGLTscscVELsGoQPhGsMcupLsVsHEGGsl-VsVchcTs	..............h...hplps.s.plcFG..slh.hsp........s.h.s.p.s..lpLpNsu..hl..s..s..pa.c...l........p......h...s..p............t....t.....h.....h...ph........................s.......lss.t..p........h........l.h......................................................................................hhh...................................................................	0	201	249	315
+14726	PF14875	PIP49_N		N-term cysteine-rich ER, FAM69	Coggill P	pcc	manual	Domain	The FAM69 family of cysteine-rich type II transmembrane proteins localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. These proteins carry at least 14 luminal cysteines which are conserved in all FAM69s. There are currently few indications of the involvement of FAM69 members in human diseases [1]. It would appear that FAM69 proteins are predicted to be have a protein kinase structure and function. Analysis of three-dimensional structure models and conservation of the classic catalytic motifs of protein kinases in four of human FAM69 proteins suggests they might have retained catalytic phosphotransferase activity. An EF-hand Ca2+-binding domain, inserted within the structure of the kinase domain, suggests they function as Ca2+-dependent kinases (unpublished).	21.00	21.00	21.00	21.00	20.70	19.40	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.23	0.71	-4.57	15	182	2012-05-16 11:38:45	2012-05-16 12:38:45	1	5	71	0	108	161	0	138.70	34	35.20	NEW	uRLshh+hKYLlhsWlullluSWVlYhpYs..oYoELCRGpsCchhI...C-+Y+pGlloGSsCpsLCspcolh.ht+C......lSsssspQl.....aouhWp-p.llIKCthpcsh+tchs.p.hs+p-hshacpPT+GTShpEF+EMV+salKsKlG-QssLssLlspllsl	.........................................Rhshh+h.hhhhshlslhl.ushl.hhhtYs...saoEhCpsc.s.+hhl..............C-cY+pGhlsGshCpsLCspcslh.at+C......Lss.pssppl.....atuh.Wps.p...sllKsthcpshc.s.htsp....scc-hs.h..h-tP....ohpcF+EMlhshhKspLG.phs...sthls.ll..h....................................................	1	21	29	61
+14727	PF14876	RSF	RSF1P;	Respiratory growth transcriptional regulator	Wood V, Coggill P	pcc	Pfam-B_36578 (release 26.0)	Family	This is a family of transcriptional regulators that determine the transition from fermentative activity to growth on glycerol [1].	27.00	27.00	35.70	34.80	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	374	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.22	0.70	-12.26	0.70	-5.66	5	29	2012-05-17 09:46:49	2012-05-17 10:46:49	1	1	16	0	8	23	0	327.70	73	82.81	NEW	MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMETPRTLNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAVQRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPKRRDIKGNHLSKLLFAKSPLTINTYCQFYDRRTKRICNQEMIWKDKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQSKIAMNDLIEILIDLNIPFSVLDYQPMRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNNSNSGTPHNHNQNQH	.............................................MKDLNPEMGKFATTKGPPQDNRGMVDIATLPNFPANRSGTPREEMYLAPNKMET.RhLNMNMVPDYLQKENFSPDFSSATVSAKSSPVNVTHDESLPLGTIESNSTKDSKYAV...QRQQQQVVDFIENNMQLLSSETLNFRSDIMKTLELPIPK..RRDIK...G.NHLSKLLFAKSPLTINTYCQFYDRRT....KR.ICNQEMIWK..DKNSREKHGSRKYQRHLSKVHDVQLTPNNFTEFFDHNSPLFQECYDYQSRLMRDLLVEPDAKFKEKKKKKKGDVNGNHPETGSSLINHQVQQQNVRELQScIAMNDLIEILIDLNIPFSVLDYQPhRNWLIKYSIISTDTLPDEVYFKTDPGVNELEHNSSNLNN..SN..SGTPHNHNQNQH................................	0	1	4	6
+14728	PF14877	mIF3		Mitochondrial translation initiation factor	Wood V, Coggill P	pcc	Pfam-B_22619 (release 26.0)	Family	This is a family of mitochondrial initiation factors IF3.	31.10	31.10	32.80	62.20	30.30	29.60	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.06	0.71	-4.91	14	37	2012-05-17 10:23:41	2012-05-17 11:23:41	1	1	36	0	26	37	0	177.60	35	49.66	NEW	+KslphcasoGS-+AppAhpsllsclathsppspl+hlsspssclEppslhchspslDLscpGlthVssp...pspt...plPLVKhVcsppAlKpYSDcLAppKEcELlphG..hs.+phtp+.cs-+ccsshKhl+lSWpISssDLspQKspEItspL...cKGp+lhl.alscKsshsss..stsc-p	.......+.hhhpasoGo-+A+pAhpsllsclaphsp.ptplchlsssssplcpsslpphspslDLscpGLplVshc..................pssptp.plPLVKllcs+.hlKpYSDhLAppKEpELhphG...sh+phtpphps-+Kc.sshKpIplSWpIsssDLppQKspEIhphL....cKGp.+lhl.alssKpshsss.........................	0	3	14	25
+14729	PF14878	DLD		Death-like domain of SPT6	Wood V, Coggill P	pcc	Pfam-B_9510 (release 26.0)	Domain	This DLD domain maintains the characteristic overall topology of death domains, as it consists of a six-helix bundle with three stacked antiparallel helices and an additional helix inserted between the final two helices of the bundle. Although it is unlikely that the Spt6 DLD functions in an apoptotic process in yeast, its prominent location and the observation that it displays the most highly conserved region of the Spt6 surface suggest that it mediates important intermolecular interactions [1,2].	35.00	35.00	38.40	38.40	31.60	32.70	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.44	0.71	-10.53	0.71	-3.98	4	271	2012-05-17 11:48:29	2012-05-17 12:48:29	1	35	233	2	208	285	1	113.10	46	7.70	NEW	h-lLDuoRlHPEsYEhARKMAsDALEYDEs..AEctsstGslpElLE.......pst+Lc-LsL-uaAEELERpsatcKt.TL.cIRhELpstYc-LRssa+s.ss-EIFpMLTtEoPET	....-hLDsTRlHPEsY...-hARKMAsD...AL.E..hD........E-........t.p..-...p..s...s...sG....A.l.cc.l.l.c..........................s.s.-.+Lc-Ls..L-taA-pL...E+p....thtcK.+tT...L.sIRsELpssYc-LRpsap...ss-..ElFsMLTGET.-.........................................	0	70	117	174
+14730	PF14879	DUF4489		Domain of unknown function (DUF4489)	Coggill P	pcc	Pfam-B_28643 (release 26.0)	Family	\N	27.00	27.00	28.20	76.20	26.50	18.70	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.86	0.71	-4.51	17	32	2012-05-17 11:57:03	2012-05-17 12:57:03	1	2	17	0	15	29	0	140.70	37	79.89	NEW	spsIlKCG.ssGusslPssos....hussasluolTlDTsshpsPCl+LEFsSNIsssssh....solNFQlaKpCcsQhsPlPVGPsao.Fut..........hluhhtopoF.SFhVCDC.DhCss-.CCTYSVssTssu.hsssushoIsNAsLuAIss-s	...spslLKCG.ssGu..sslPhsos....husshslAololDTsshcsPslpL-FuSNIsssssh.....thsLNFQlFKpCcsQhhPhPVGPsas.Fsp..........................hlsshsopoF.SFhVCDC.DsCssc.CCTYSVssossu.hsssusssIsNAsLuAlhss...	0	6	15	15
+14731	PF14880	COX14		Cytochrome oxidase c assembly	Coggill P	pcc	Pfam-B_122767 (release 26.0)	Family	COX14 plays an essential role in cytochrome oxidase assembly. The COX14 product is a low-molecular weight membrane protein of mitochondria, but it is not a subunit of cytochrome oxidase [2]. Orthology-prediction methods have identified the vertebrate C12orf62 orthologues to be orthologues of the yeast COX14 [1].	25.00	25.00	25.20	25.00	24.30	24.70	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.73	0.72	-4.34	45	167	2012-05-17 14:06:12	2012-05-17 15:06:12	1	2	159	0	124	156	0	57.10	23	37.66	NEW	thhsttc+lhDtsHRssVhoLlGhTshuushhsas.....haphhpa.+pp+t......h.tpccpt.t	......h....hucphsDhsH+ssVhollu..hTlhuGhlsshs.....hhphhphp+pp+t......h.ppph...................................	0	27	55	96
+14732	PF14881	Tubulin_3		Tubulin domain	Coggill P	pcc	Jackhmmer:Q9P6K5	Domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Misato from Drosophila and Dml1p from fungi are descendants of an ancestral tubulin-like protein, and exhibit regions with similarity to members of a GTPase family that includes eukaryotic tubulin and prokaryotic FtsZ. Dml1p and Misato have been co-opted into a role in mtDNA inheritance in yeast, and into a cell division-related mechanism in flies, respectively. Dml1p might additionally function in the partitioning of the mitochondrial organelle itself, or in the segregation of chromosomes, thereby explaining its essential requirement. This domain subject to extensive post-translational modifications.	30.00	30.00	32.00	30.20	29.40	29.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.21	0.71	-4.81	18	276	2012-10-03 12:11:42	2012-05-18 09:44:05	1	11	230	0	183	277	1	185.30	29	35.18	NEW	sPpLTo-oVRYWSDFNRVFYHPRSIVQLN-Y.EL..NSp..lM...P...F...EcWssGE-LFssLDKEHDLLDRDlRPFAEECDQlpGlQlFTGsDDAWGGFAA+Yl-RLRDEYGKpuh.hWsa.ul....psshptptph.h.+.phtt.h.NpARSlppl.us...QuShalPl........s........p........l.........s.........c....s......pS..t.....WasSALlusAlESsTLPoRL	................................................psl+hWSDa.+lhaHP+Sls.lp.........pa..ph.........ssp.............hh.................t.........F.........-s...au..hGpslap...p..s...hp...c...-hh.D.......R...........lRhalEECD...tLQ...GhQllsDhcsuauGhuu..phl.-pLpDEY.......spps....h.....h.....a.s..h...sh................t.ss...t....t......p..t.p....t..........pp....h.h.chl..NsAhuhsplsp.....puo.....lhsPlu.............p.................s.............ss.................pp.a.asSAlhAsAl.-oholPhRl.............................................................	0	53	95	145
+14733	PF14882	GHL12		Hypothetical glycosyl hydrolase 12	Coggill P	pcc	Naumov D [3]	Family	GHL12 is a family of hypothetical glycoside hydrolases.	27.00	15.20	27.70	16.40	26.00	15.00	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.80	0.72	-3.87	38	137	2012-10-03 05:44:19	2012-05-18 09:59:44	1	19	28	0	72	140	139	48.70	34	25.22	NEW	EYpc+YKcDP+LPSsPsphY..pc.-Wp...uWhsFLGsp..pchYsTht-AppAshpL	............Yhp+Y+cDP+LPusPpp..hY..ps.-Wt...uWhsFLGs...t......t...hY.ohttAptus.t.......................	0	16	28	48
+14734	PF14883	GHL13		Hypothetical glycosyl hydrolase family 13	Coggill P	pcc	Naumoff D, [3]	Family	GHL13 is a family of hypothetical glycoside hydrolases.	27.00	27.00	47.50	45.90	23.10	22.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.90	0.70	-5.26	12	474	2012-10-03 05:44:19	2012-05-18 11:51:12	1	3	410	0	61	295	6	291.70	52	48.30	NEW	HIDLDYVYDsD.tQps+NLshLlpRlhchtlooVYLQAFuDPDGDGhADAlYFPNRaLPhRADLFsRVAWQL+TRAuV.p.VYAWMPVLuaDL....P.s.sp..ptphlssp....ph.t.....t...cs.......hh..RLSPass+spphlppIYEDLAht.AtF-GILFHDDAhLs.DhE..................hs....th.p...st....u..............s........t.................h..........KopsLlcFThpLsstl+....th....c...Ppl+TARNlaAtsllpPpuEsWFAQsLsshhpuYDhTAlMAMPaMEs..sp.....p.....scpWLtpLlstVcspssuhcKolFELQuhsW+..s......pps.lspspLhsa.hphLQtpGlhsaGYY	........................HlDLDYVYD.s.pQ.-+NlDhLIpRlpDMploTVYLQAFA...DP.......D......GDG...h....l.....c....p.VaFPNRhLPM+ADlFuRVAWQL+TRuGV.p.lYAWMPV..Lu..a..-L.....P.s..ls...c.h..chlsst.......pt.c......scp........Yh...RLSPFcscsRtplt.lYEDLAta.AsFDGILFHDDAlLS.DaEDASssAlpA.......YpphGhssslucIR...ps....sp.....pht............pWsR.................................a..........Ko+sLsDFThELsspV+sh....R...uPplKTARNIFAh.PllpP.-.SEAWFAQNhsDFLc.sYDaTAlMAMPY....hEs....ls........-..u-pWLhp.Lsspl+shPtuh...cKolhELQApsWp..p......pps..I.soppLApWMphLphs.GspsaGYY..................................................................	0	14	31	46
+14735	PF14884	EFF-AFF		Type I membrane glycoproteins cell-cell fusogen	Podbilewicz B, Coggill P	pcc	Podbilewicz B, [1], Pfam-B_25631 (release 26.0)	Family	EFF-AFF was first identified when EFF1 mutants were found to block cell fusion in all epidermal and vulval epithelia in the worm [1]. However, fusion between the anchor cell and the utse syncytium that establishes a continuous uterine-vulval tube proceeds normally in eff-1 mutants and thus Aff1 was established as necessary for this and the fusion of heterologous cells in C. elegans [2]. The transmembrane forms of FF proteins, like most viral fusogens, possess an N-terminal signal sequence followed by a long extracellular portion, a predicted transmembrane domain, and a short intracellular tail. A striking conservation in the position and number of all 16 cysteines in the extracellular portion of FF proteins from different nematode species suggests that these proteins are folded in a similar 3D structure that is essential for their fusogenic activity [3]. C. elegans AFF-1 and EFF-1 proteins are essential for developmental cell-to-cell fusion and can merge insect cells. Thus FFs comprise an ancient family of cellular fusogens that can promote fusion when expressed on a viral particle [4].	25.00	25.00	58.70	28.00	18.70	18.20	hmmbuild  -o /dev/null HMM SEED	589	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-13.15	0.70	-6.45	4	33	2012-05-18 13:38:09	2012-05-18 14:38:09	1	2	10	\N	29	26	0	393.20	31	92.34	NEW	MhlhphlLhhhh.hhl.h..............s.Shh...hCscoh.hpu....psctsusplspThphQhpIGLppThCFhLp..sspc.S...sl..uh.sp.pslLHsLpYEplEpcYPlcppYpFulPcl-osClC-CsuhuDhCsscstphscpt.ssTspp..shCapTYHPsQsstGC....sutpuclCCcl.hpPhps+.YVAh+lpQPhssssapas...hasppuhchap.hscpphps.sstspph..hschtplplth.s.ups.pQLcpGMYahs.psps.hh-ht...INclsE.shcKLGWhR.ptss.casVRsuclplpsAHhlpscNC+sQhphsphsupahhs.pts.s.pcaa.GptVEch.sWlRoV+l.-..souRplpVhpppusslsVtLp.hpossshshhactScLs-FouolplDt+SNRFhNlThhsspGolhGpl..Yp.sss+pssspatFosalG.pspspNsshRIuLPuhIN.GsphlCLpP.pcPs...pElC+hlsFpppALppshl.poWppu..cutCspsNp.sLtsFlu.LNPspWhpsls.......uhhEhhthslclshhlshhhlhhhlpp+slssl	....................h......................................hp..aCsc.s.hpup.....pts.pth.phhph.hphsLppshCh.h.......................ps.lHslph.phEppaPlptpY.FulP.lpssChCcC.t.tp.ss.p....................Chppahst.ts.sC.....s..sphCCtl......sh.ahAh+ltpP.s.hhhhat....at..s.t.h..ht.p.hp........tt.t...h.t.tphplth.s.uts.pph.pGMYa..ppsts...clt...lNEls-sshc+LGWhR..c.ss.ca.VtsuhlhhpshH+shlcNCKtQhahs.hsup..h.......................tch..tt.lp..psWlpsscl.-..to.RphhlsHtcGTslplulp....sp..s...p................shh+stScltsFsGoIhlDpcSNRhhNlThatupGpltGpl..hh.sst.hp.s.ashoh.hu.....phtsps.hlsLPu.ls.tsphlCl.ssp.ss...tplC+hl.a.pps.lc.sh....tpWpth...u.Cspspp.shtshht.h.P..Wh.shp.......shh-hhhhshclslhhhh........hh.h...............	0	14	16	29
+14736	PF14885	GHL15		Hypothetical glycosyl hydrolase family 15	Coggill P	pcc	Naumoff D, [3]	Family	GHL15 is a family of hypothetical glycoside hydrolases.	27.00	27.00	27.00	51.50	26.80	26.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.52	0.72	-3.77	16	26	2012-10-03 05:44:19	2012-05-18 17:04:23	1	2	26	0	10	26	0	76.50	32	17.93	NEW	hssussa.ttpsh.s.psssaau+chsGppl..pWpGast+aphhshs.....ssaRttWVstlsctlp..ss......saDGVhhDNsshs	..........pus.a.htpph.p.pptsWhA+cssGctl..EWp.s.YstHaQhtVWs.....ssYRttWlcpVsptht..so......saDGVhADNDlh..	0	3	6	9
+14737	PF14886	FAM183		FAM183A and FAM183B related	Coggill P	pcc	Jackhmmer:Q6ZVS7	Family	The function of this family of metazoan sequences is not known.	27.00	27.00	27.10	27.10	26.80	26.40	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.87	0.72	-10.63	0.72	-3.52	36	120	2012-05-22 14:57:57	2012-05-22 15:57:57	1	5	77	0	86	127	0	103.70	30	53.97	NEW	plh+EhlcKEp+p...+lhsp.FslsPhpph..slTpKP.sph.......................s.tc.ppstphhphhp.....ctpppPpcKash.PhTpuQEhGWhspshhp..........tpcpphpas+pps-lTpas	...................................................................tlhpEhhhKE.+p...+lhsp.aplsPhp.........phh..slTcKPhuhp...................................................ssh-t.ssscaLphl+.....+sspsPpcKYsh.PpTEuQElGWhspsllp.t................ppcpphpa.+hps-lThah.............	0	40	49	66
+14738	PF14887	HMG_box_5		HMG (high mobility group) box 5	Eberhardt R	re3	CATH:1l8y_A_00	Family	Nucleolar transcription factor/upstream binding factor contains six HMG box domains. This is the fifth HMG box domain in these proteins. This domain has lost DNA-binding ability [1].	25.00	25.00	25.00	25.00	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-10.05	0.72	-4.20	4	102	2012-10-02 14:16:02	2012-05-23 15:39:34	1	15	38	3	41	95	0	82.70	69	13.76	NEW	uKLPEoPKTAEEIWQQSVIGDYLARFKsDRsKA.KAMEuTWpNMEKKEKIMWIKKAAEDQKRYE......REL.EMRossAus.suuKKhKF	................uKLPEoPKpAEEIWQQSVIGDYLARFK.NDRsK.A.LK.AMEhTWsNMEKKEKLMWIKKAAEDQKRYE......RELSEMRuPPAus.sSuKKhKF....................	0	2	7	23
+14739	PF14888	PBP-Tp47_c		Penicillin-binding protein Tp47 domain C	Coggill P	pcc	CATH:1o75_A_04	Domain	Domain C is the largest domain in this unusual penicillin-binding protein PBP), Tp47. This domain is mainly characterised by an immunoglobulin fold with two opposing beta-sheets that form the typical barrel-like structure. In contrast to the classical immunoglobulin fold, however, this has an additional beta-strand inserted after strand 3. Also, the strands are connected by rather large loops. Helices are inserted between strands 2 and 3 and between strands 4 and 5. Domain C interacts with domain B via a surface that has a slightly concave, goblet-like shape. Tp47 is unusual in that it displays β-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP [1].	25.00	25.00	47.30	45.40	24.70	17.20	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.07	0.71	-4.63	14	25	2012-05-24 12:59:46	2012-05-24 13:59:46	1	11	25	2	2	24	2	159.30	51	20.57	NEW	ssTNGLKTAsKsuDGoFoFSAR.ssGTpSGlKDpsLKsA...sslsssVKpAo..GSYGEFLRVDLsGs.YGsLGAsMQAVKWTYYGsDSTYTpslAoYGTKFAADNWMHKuMGIQLGLTDSlRCpLPtGTDGTGYWolTVYALGYsDhTapFpATcpNIVKspsssss	..NTNGLKTAhKppDG.aoFSAR.psGotSGl+DtslcTA...oshpspl+suu..GSaGEFlRVD...Ls.G-.YGDLGuNhQuV+WsYYGDDuTYTsshASYGTKFAADNWMHKuhGIQLGLTcShRCpLPcGsDGTGYWpLTlhALGYpDsshcFpssttNlsp.t....pt.....	0	1	2	2
+14740	PF14889	PBP-Tp47_a		Penicillin-binding protein Tp47 domain a	Coggill P	pcc	CATH:1o75_A_03	Domain	This is the first domain in this unusual penicillin-binding protein PBP), Tp47 is mainly composed of beta-strands and is sequentially non-contiguous. The first three domains in Tp47 interact with each other through intimate domain-domain interfaces. Domain A contacts domain B through its N-terminal segment. Domain A also interacts tightly with domain C, Tp47 is unusual in that it displays β-lactamase activity, and thus it does not fit the classical structural and mechanistic paradigms for PBPs, and thus Tp47 appears to represent a new class of PBP [1]. 	25.00	25.00	55.60	49.50	19.40	18.50	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.13	0.71	-4.93	13	26	2012-05-24 14:39:44	2012-05-24 15:39:44	1	12	25	2	2	25	2	163.80	45	21.76	NEW	ptpsEYsYVYAGLTWuEYWAuEGVYAAGDTSSSsptDSHsEhDKGAFDsVTRATsNHGLHRGSaQ..CtAsIhscsGs..pYplSaWss.........ssphlLTDGos.loas.....RGs...ITpsDGootphscYcVsGlKYVPVKVKouDasAFcucYsVVENGupLsGGauENsLpSYp	........u.pcEapYsYAuLoWu-YWAuEtV.uAs.ssuuss-tDp+sEhDtGuFDsVoRATsNHGLHRGSFQssshlhuc..cuh.......saslptWpt.............tsp.slTcssp.sohs.......................Ruo.hhsDupphclspYcVpGhKYVPVtVtspDhsshKpKaplVEsut.L.GGauEtpLpsYp............	0	1	2	2
+14741	PF14890	Intein_splicing		Intein splicing domain	Eberhardt R	re3	Jackhmmer:D7E146	Family	Inteins are segments of protein which excise themselves from a precursor protein and mediate the rejoining of the remainder of the precursor (the extein). Most inteins consist of a splicing domain which is split into two segments by a homing endonuclease domain. This domain represents the splicing domain [1].	26.50	26.50	26.60	26.50	26.40	26.40	hmmbuild  -o /dev/null --hand HMM SEED	323	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.82	0.70	-5.54	5	448	2012-10-03 10:25:13	2012-05-25 15:14:27	1	159	235	3	197	474	68	305.80	19	35.05	NEW	DSLVpLsDsGh.VsIK-LVGcs-FsVlAlNpcThKLEoApVo+sFsTGsKPVFcLKTRLG+oI+ATANHKFLTI-GWKRLDc....LsssppIuls.........................................................................................................................................................................................................................................................................................................................................................................................E.htplushsQs..l.thspocIYWDcI.lSIpPsGVEpVYDLTVPsLHNFVANNIIVH	............................................................................................................................................................t........................................................................................h.t..h...h....p....s..p....lhc.....lpht.Gtpl.psTssH.hh..s...h.p...........s...............h.....p.........l....tp...........Lp.G-h.lshs....................................................................................................................................................................................................................................................h....h.................................t....t.......h....h.......huhhhu....-...G....h......................t............................................h..............p.....................h.t........................................................................................................................................................h..........................................t...t.....h...Pt.lh.t.........h..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t.....................................................................l......h.h..p.....s.c..h....h....a......c....pl...h...pl.p..............s....p.....VaDh.p.l...t..Hsal.uss..h.......................................................................................................................................................................................................................................	0	47	107	153
+14742	PF14891	Peptidase_M91		Effector protein	Eberhardt R	re3	Jackhmmer:D3QNI8	Family	This family of proteins contains an HEXXH motif, typical of zinc metallopeptidases. The family includes the E. coli effector protein NleD, which cleaves and inactivates c-Jun N-terminal kinase (JNK) [1].	25.00	25.00	25.10	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.19	0.71	-4.20	13	118	2012-10-03 04:41:15	2012-05-28 13:09:29	1	14	96	0	40	155	31	175.40	23	37.51	NEW	ssstlphcGo-.cFtc+lcAuLD+luSosTGcphLpsl.....pohsp....s+pcclsIsEtsscpsssspsshstp..............................GsssplshNPs.p..ht.s.tts.hp.s...t.ssslLhHELhHsachLsGop.....tsp...s.....spssssst-EtpAVGLstasa-..tps...............hoENulR-EhGhP+RspY	........................................................................................................................pss.p..phhpphpssLphltss..sGpthLptl.........pthtt..........tpcplslp...t.s.p.ss.s..ttshsht.ht.......................................stGsssplphsss.......ht....s..sssshp.....t.t....t..hssLhHELlHAhchhsGsh.....................tsch...st.................pptsshsppEhcsVGLst....aspp.................................................hoENtlRpEhGhshRppY......................................................................................	0	19	23	33
+14743	PF14892	DUF4490		Domain of unknown function (DUF4490)	Eberhardt R	re3	Jackhmmer:Q5BN46	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 101 and 220 amino acids in length. In mice, a member of this family whose expression is induced by p53 may play a role in DNA damage response [1].	27.00	27.00	30.40	29.70	26.30	22.00	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.31	0.72	-4.39	11	94	2012-05-28 14:49:04	2012-05-28 15:49:04	1	1	70	0	62	110	0	94.10	31	61.20	NEW	hpppssctptp.hps+sss...+TS-hY+lscsLPpR..FsNPspF+GYus.ps.ssshYRTSNppYGphsPTsHEhPpsFaPpspKFSpclstuGMaRssuLNThl-KSh	........................................................................pptphh...tp..l.tR..hpsP..F+GY...ts.pc..ssshY+ToNpsYGth.sP.......osaphPppaaspsppFS............pplstsGha+sssLNshh-cp.h...............	0	31	36	49
+14744	PF14893	PNMA		PNMA	Eberhardt R	re3	Jackhmmer:Q86V59	Family	The PNMA family includes paraneoplastic antigens Ma 1, 2 and 3, found in the serum of patients with paraneoplastic neurological disorders [1,2]. The family also includes modulator of apoptosis 1, which has a role in death receptor-dependent apoptosis [3].	25.00	25.00	25.00	25.00	24.70	24.90	hmmbuild  -o /dev/null HMM SEED	331	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-12.15	0.70	-5.42	13	255	2012-10-02 13:37:57	2012-05-29 14:18:52	1	13	30	0	128	295	0	253.30	30	58.05	NEW	M....ALsLLcDWCRGMslNs+RuLLIlGIP--CuEsEhpEuLpAuLtPLGcYRVLG+hFRRE-NuKAALVEluptlNhoLlP+cIPG+GGsWcVVF+P.ssDsEF..Ls+LscF.LcsEGpsh..p-luRsLGssstsssst.s....p...Wscslupsl..shQPhh.EshtYpcL+lFSG....p-pPusGEEoFEsWL-Hss-hlph...................Wp.VSEpE+RR+LlESLtGPALcllpsLhtpNsshost-CLtALtplFGsp-sptsspl+aLsssQcssEpLpA....aVlRLEsLLQKAVcKuAlp.sssssQsRLcQVLutAphspsLps.......+L+hhphcppP.PuFLpLL+	.............................................................h.hLp-WC+..ths.p+shhlhGIP.tht........-hptslp.sh...s.aplhthhhhpp.t...pssllphstthshshlPpch..GpG..GsWcVlhps.s.-s-h..hpplp.F.Ltt-G.s.h...tshst..hlt.ts...s....t.........hsc.hs.h...h.ts.pshh...hhh...pphp...lFSG....pt.st..t.cEsFc...sWh...pssp..h..l.........................Wp...h..s-.E+h++lhcsLtGsAhpl.hphlttpNsths.stphLpuht.sFGs.-s.....hshph+hhps...Qt.sEphps....alhRLEshLppshppssht..ptss......psRlp..phh.tu.hst...........phc....h...h....t......ttt..Pshhthh...........................................................	0	32	35	40
+14745	PF14894	Lsm_C		Lsm C-terminal	Eberhardt R	re3	Jachkhmmer:Q8ZVU2	Domain	This domain is found at the C-terminus of archaeal Lsm (like-Sm) proteins [1].	27.00	27.00	63.20	62.30	20.90	17.00	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.65	0.72	-9.02	0.72	-4.46	14	43	2012-05-30 08:12:54	2012-05-30 09:12:54	1	3	42	28	23	37	0	62.80	46	43.66	NEW	h+EFA-hlp+...lhPshVKlh-EsslVhV.-+l+VoEpGV.EGoGPhApRlhclacEYlcp+Kc	..REFA-hlpKphtlhPu.VKlhEEssVVhlh-+l+VScsGV.EGSGPhApRlhcLYp-Ylpc+K+..	0	6	11	16
+14746	PF14895	PPPI_inhib		Protein phosphatase 1 inhibitor	Eberhardt R	re3	Jackhmmer:Q96LQ0	Family	This family of proteins interacts with and inhibits the phosphatase activity of protein phosphatase 1 (PP1) complexes [1].	25.00	25.00	27.10	26.00	22.60	19.50	hmmbuild  -o /dev/null HMM SEED	347	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.40	0.70	-12.13	0.70	-5.71	17	94	2012-05-31 15:19:19	2012-05-31 16:19:19	1	3	58	0	59	99	0	304.60	35	76.71	NEW	asDLpc..AcERYIpTNG..............aKFLRTlsQEEElIFRptFsRscsoaDt........DTVllsDlRDLVLFhMPcEFLo..hKFlpFMHpPsVaRLLHuLlIYFEYaLRhVEFlLIRRDELuGphuQlQSEQTN-MKRlaShYLSQYRhLVARNYshIlpGEGDhscaYHh....KcllNI..SuTI+D+hFHEQFLAVuTQIVWIsMHRRAYhlIEMEMNRLFRSEHFlhsR.EYL.........cFTssERSLLYGRssKlhNYRsQhSPLlQELpplscEDhPILWIGERKYRGoDhRIsplELEYlVPGsQL+hIDVuHGILGHPKpLYN..TlL............sLDWPuVRauNaS.paDPYallRQPpLcIPpIs-hphRKh	.......................................................sh.p..hcE+hh.spu..............h+Fhch.s.tp-hlhcpth.st.tpsp.s.................sslslpDl+.lsLhLh.pp.....hp..hpF.hpFM+p.slcphLhALlhYhpaaLchsph......Ehpsp...h.lt..ppp-hchhhSh...LpthphhlAppYshllhG...u.hschaHM....Kp..pI..SsT.+DhtFaEpFhshss...lsWIsh+Rpta.p.I..............E.Ehs..............RLFRochFshs.Rtch.....................ch..T.sphph.h..hu........+pst.lh.p.......hhs.pSPllppLh.s.cEch....lsc+KY+tssh+lsthp.c.hlsshspl.h.sV..GILGcP+pLas..TlL............sL-..t....shp...hc...lhcpsthpI.ph.th.h+p......................................................................	0	16	18	37
+14747	PF14896	Arabino_trans_C		EmbC C-terminal domain	Bateman A	agb	Pfam-B_4670 (release 7.5)	Domain	Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the   macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1]. This domain represents the C-terminal extracellular domain that is likely to bind to carbohydrate [2].	25.00	25.00	28.20	27.20	18.40	24.40	hmmbuild  -o /dev/null HMM SEED	388	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.30	0.70	-5.87	7	454	2012-06-06 15:10:05	2012-06-06 16:10:05	1	7	175	1	94	412	0	346.80	41	34.95	NEW	EluShstGhVtpYPsYosGpANltALsu....ssCuhADDVLVEsDsNAGMLpPlPut.aGs.GPLGGhsslGFsPsGVs-clpu-PVhppPGpsso-s..sps.ls.u.pssT.uGshussGlNGS+shLPaGLDPsRTPVhGSYsps.p.sAphoSAWYpLP....spst..s+PLVVVoAAGtIhuhp..tsh.hGQolcLQWusscPsGsh.PhuplpPhDl.GspP.AWRNLRaPLo.hPs-AsssRlVApD.sLosppWlAhTPPRVP.LpTLQphlGSpsPVhhDhtsuhsFPCQRPFscphGVsElPcaRIlPDhhtttssSshWpsutsGGPhhhhphLLRsoslsTYL+cDWaRDWGSlc+ah.lVP.DttP.Atl-.GohThsGWhpsGPlRhh	..................................................................................lsShst.uhltQYPsaSsutuNlpAl....sG....ssCulA-DVLVEsDsNsGhLpP..l....s..u...p........h.....us.....................s...L..........u.u......s.......s.....s..hGFsPsGls.....p.clp........u.-........s...............hh.....t.......ps......u..............ts.s.s..............s..s.........s....ts.............s........sts....u...s............T.........s....G.t.t...ussGlN....G.Sp.stLPasLDPu+sPVhGSa.sp....s..........p...........AplsSuWYpLP.....tp.st......stP...L.lV.VoA.AGplts.hc........t...h......Gp...pl......hlpauh......s...t.....s...s..G....s...h...p....s.h.G.p....h......hD...l..G.s..........tP...uWRNLR...hPhuthPscAsslRlVApD.sLsscpWlAhT.PPRlPpLcoLpphlGSssPVL.lDWsVuhsFPCQRPhsc.t...GVsE..lPc..aRIhPDt.sttssoshatsttsG.GshGhs-hLhcspslsoYLpsDWhRDWGulpcap.hss....stt.....P..Ap..lphGohT+oGhWpP.GslRh.h....................................................	0	15	64	85
+14748	PF14897	EpsG		EpsG family	Bateman A	agb	Jackhmmer:B0MX13	Family	This family of proteins are related to the EpsG protein from B. subtilis Swiss:P71056. These proteins are likely glycosyl transferases belonging to the membrane protein GT-C clan.	27.00	27.00	27.00	27.30	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.72	0.70	-5.51	270	873	2012-10-03 03:08:05	2012-06-06 16:27:04	1	2	639	0	156	806	120	316.40	15	89.49	NEW	hhhhhhhhlhlhhhsuh+h.ss........s..Dah...sYh.phapp.ht................................hthE......Gahh..lshlhph.lsts......hthhhhlhuhlhhh..hhhhhlp+hsp..........hhhshhha..hhhhhh.h.....hRQslAhu.l.hhh...u.ltalh.....c+c.....hhtall....hlllAshF.H.tSu...llhlsh....hhlhp.hchp..........................hhhh.....................................................................................................hhllshh...........lhhhhhhshlhphhs.h...................phstYhptsthstsh.........hhthhhhhhhhh..........hhhhhhhhtppht.....................phhhhhhhhsh.hhhhlhhhh............hhhsRlsh......aahhhhh......hlhshlhp.............hhptp...ppp..................h..hhhhhllhhhhhhhhthh.h................hhPYps	..............................................................................h...hhhhhhhhhhhsuhRh...th........us..Dhh..sYh.pha.pt.htt.................................hth.E....ua.hh..l....hl.h.ph..h..s.ts.......h.hhhhlh...sh.ls...hh....hhh.......hhhtc.h.spt................hhlslhla....hhhhhh.hh.ph.stl.Rpsl.Ahu..l.hhh.......u.lh..hlh.............pcc......hhphhl....hlllA.sh.F.H.hSu.....llhl.h..........hhlhp...hphp.................hhhh.....................................................................................................hhh.h..hhh.........lhhh...hhh.s.lh..shhs..h..............h.t..............phshY.hptt.tttth........................hhthhh.hh.hhhh........................h..hhhh.hhhttpht........................thhhphhhhsh.hhhhhhh.h..........hhhsR...hsh..hhhhh.h..hhlshhlhp..........hhtpp....tpt..............................h.......hhhhhllhhhhhhhh.hh.....................................................................................	0	50	103	133
+14749	PF14898	DUF4491		Domain of unknown function (DUF4491)	Bateman A	agb	Jackhmmer:B0MXX8	Domain	This family of proteins is found in bacteria. Proteins in this family are typically between 94 and 107 amino acids in length. There is a conserved EYY sequence motif.	27.00	27.00	42.80	42.60	21.70	20.20	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.11	0.72	-3.84	40	168	2012-06-07 11:57:47	2012-06-07 12:57:47	1	2	159	0	29	132	11	92.20	53	89.23	NEW	hsapGllIGlsoFlIIGlFHPlVIKuEYYFGp+hW.lFLlhGIsslssSLhlpsllhSulLGVlGhSsLWSItELaEQc+RVcKGWFPcNPKRK	....phsGllIGlsTFLIIGlFHPlVlKuEYYaGo..+.sWhlFLllGIsslluSLhlcslhlSulLGVhuhSshWoItElFEQccRVcKGWFP+NPKR+......	0	18	27	29
+14750	PF14899	DUF4492		Domain of unknown function (DUF4492)	Bateman A	agb	Jackhmmer:B0MUW2	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 80 amino acids in length. The function of these proteins is unknown.	27.00	27.00	35.40	35.20	21.80	19.50	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-9.02	0.72	-4.47	47	245	2012-06-07 12:06:30	2012-06-07 13:06:30	1	1	244	0	25	127	0	64.10	55	83.98	NEW	hh+lachYhDGFRsMT.LGKTLWhlIlIKLFIMFslLKlFFFPshLppp..tscp.p+.usaVtppLhp	.....pIFsFYhEGF+shT.LGKTLWtIIhIKLFlMFhILKLFhFss.hsoh..psDpEKusFVhcpLh....	0	11	22	25
+14751	PF14900	DUF4493		Domain of unknown function (DUF4493)	Bateman A	agb	Jackhmmer:B0MWC6	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 264 and 710 amino acids in length. Many of these proteins have a lipid attachment site suggesting they are lipoproteins.	27.00	27.00	27.30	30.50	26.60	26.90	hmmbuild  -o /dev/null HMM SEED	235	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.71	0.70	-4.74	66	146	2012-06-08 12:54:42	2012-06-08 13:54:42	1	5	36	0	25	139	5	229.40	19	45.16	NEW	pspGhLp.....Lslsss..............ssstT..+ussstt.t.......ssssatlpIhsss....sthhpptphsphs......ttlpLssGs.YslpAp.hu..-ssss..uhct...PaY.tGpp.shslpp.spsssss..lsCpluNstlslsa....sps.htshF.ss.....aplpVssu.........ssslsa.......tscs...cssYatssp.........pl..phslpuspp.s.s...spstph...................pslpsssph.plshshs..................psGss......slslslsps.spshshslplssph	......................................tpGhLp.....Lslssp..............ssstT.+usspt.................phpsaplpIhsss.........sslhp.sshschs......ppltLssGs.Ys.lpAh.hG.......-ssssuh-p.....PYY.tGpp..shslpp.spss.sls..lpCpluNstVolpa.........scs.htphF.ss.........aslsVssu..........ssslsa......ttsps...cssYapssp...........pl.phslpuspp.s.s....spptsh...................pslpstppa.plshshp...........................psuth......slslsl-ts.hpphshshtls...........................................	0	5	20	25
+14752	PF14901	Jiv90		Cleavage inducing molecular chaperone	Coggill P, Hetherington K	pcc	Pfam-B_1192 (release 26.0)	Domain	Jiv90 is a fragment of the DnaJ protein in eukaryotes and in J-domain protein interacting with viral protein (Jiv) located in the N terminal region of the pestivirus viral polypeptide.  The viral protein interacts stably with non structural (NS) protein NS2, causing a conformational change in NS2-NS3 and stimulates NS2-NS3 cleavage in trans. Cleavage of NS2-NS3 increases cytopathogenicity and consequently aids viral replication. Jiv therefore acts as a regulating cofactor for NS2 auto-protease. The efficient release of NS3 from the viral polypeptide by Jiv is considered crucial to the pestivirus cytopathogenicity [1]. In eukaryotes, it usually lies 40 residues downstream of DnaJ family Pfam:PF00226. However, the function in eukaryotes is still unknown.	27.00	27.00	27.90	27.90	26.20	16.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.33	0.72	-4.00	20	161	2012-06-08 14:47:20	2012-06-08 15:47:20	1	17	91	0	88	157	0	93.00	51	11.91	NEW	puupsItCspCsshHhthtTc+.stupARaCpcCphhHsA+-GDlWsEsshhGhha.........+hYsCh-upVYDIT.............EWAsC..Qthth.......psNTHpVpa+lshs	.....EshNThhCo+Cts+Hh.RhphcR.p.tsARaCs-CsphHsAc-GDhWAEoS.hh.GL+h.........pYFAhMDGKVYDIT.............EWAsC..Q+sul.......sPsTH+VsYHIshu..........	0	20	36	62
+14753	PF14902	DUF4494		Domain of unknown function (DUF4494)	Bateman A	agb	Jackhmmer:B0MZU7	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 154 and 172 amino acids in length. There are two conserved sequence motifs: VDA and EAE. There is a single completely conserved residue E that may be functionally important.	27.00	27.00	77.50	77.40	23.30	22.20	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.14	0.71	-10.69	0.71	-4.57	28	161	2012-06-11 12:23:02	2012-06-11 13:23:02	1	1	137	0	32	137	51	139.90	55	85.59	NEW	WFEsKl+Y-KshE.sG..........hpKpVoEsYlVDAlSFTEAEspIhEEMusal..o.GEFclssI+pAsYuElFFs-h-ssD+....................WaKuKlpFITlDEKotKEK+ossshLVQAsolppAlcpl--sMu..sThlDYsIsulsETpIMDVF.ap	.WFECKlRYEKshE.sG.............hpKKVTEsYLVDALSFTEAEuRIIEEMosaI..S..GEFsVosIK+AsY..uElF...S-t-suDR....................WFKsKLhFIT...lDEKS..G....tEKKTssphLVQAssl+-AlK+l-EsMc..uTMuDYpIuulsETsIMDVaPY......	0	12	28	32
+14754	PF14903	WG_beta_rep		WG containing repeat	Bateman A	agb	Jackhmmer:B0MSK5	Repeat	This repeat contains an N-terminal WG repeat motif. The extent of the repeat is poorly defined. This repeat may form a beta solenoid structure (Bateman A pers. obs.).	25.00	11.50	25.10	11.50	24.80	11.40	hmmbuild  -o /dev/null HMM SEED	35	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.34	0.73	-7.86	0.73	-3.53	486	4416	2012-06-11 14:25:50	2012-06-11 15:25:50	1	86	508	0	1201	4277	336	36.40	27	39.14	NEW	aGh.....lsp..pG......ch.l..l......s.s.p...Ycp..............h.....t.s...a...p..s....u........................h.shV..............p..p..s................s.....................................c.........a	...................aGa..lcp.pG.......ch..l..l......s.s.p........Y-p....................................s.........t.s....F....p..p......G..........................................h.AhV..............p.....t...............t.........................................................................................	0	586	987	1110
+14755	PF14904	FAM86		Family of unknown function	Coggill P, Hetherington K	pcc	Jackhmmer:A6NEL3	Family	Function of this protein family is not known.	23.50	22.10	23.50	22.10	22.90	21.90	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.28	0.72	-4.26	3	140	2012-06-11 15:45:07	2012-06-11 16:45:07	1	5	47	0	46	98	0	79.80	52	31.85	NEW	MAPEE+AGAspLLQGFERRFLAARALRSFPWQSLEEKLRDSSGSELLLDILQKTVKHPVCVKHPPSVKYSRCFLSELIKKHEAVHTEPLDcLYEALAEVL	.................................ttt.lLpsFpR+FLAsptLtoFPWp...S...LEtKL+...-SSs........S..E...LLp...DI.L........p.KT...V......tHPlCl+aPPSl+YtppFLoELI+KpEusth-slDpLYcsLsph..................	0	19	21	28
+14756	PF14905	OMP_b-brl_3		Outer membrane protein beta-barrel family	Bateman A	agb	Jackhmmer:B0MXY4	Family	This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.	22.60	22.60	22.60	22.60	22.50	22.50	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-12.97	0.70	-5.81	316	2158	2012-10-03 17:14:37	2012-06-12 10:57:21	1	25	394	0	605	5700	1826	472.30	13	60.34	NEW	s..tp...h.p...p......p...s.p...s..p...sp.s.p..s..h..sh..phuh..s.Yp..l......ss.....pp.sluh....phshp...hst..tpt...ps...................sspsp..........................tth..............ths..pppppp.ptppt..shshsltYptphs.p.sp..p..lsh..sh..s..a..sht..ps..ss.......ppp..hpp....p..h...............t....ppph....t..sps...pp..p.phhssplsaspsl.s..c......t..plphG.hchshspsp.ssh...h....t.hp..............s.t...th....................................................................s..........s..ssp.......hphpcphh..usYssas...t.p.h......s..+....h.sh..psGlR....hE..h....sp..h......................ph...pp...........t..h.t.p.......p.....p............psa.hs..hh..Pohs..lsa...phspt...p..lplshspchhppPshtpLss.hhp.ht.s.s.hshppGNPtLcPp..hspshpls...a....s.h.....c..pt........h...phs....hsh..pa..s...pst...h.........th...s..h.h...........pt..........s.p..ss..........................................hh..hhp.tN..h.spp.pph..shslshsh...ph................sph...hphs...........h...shshhht.p.p....s.................s....st..hs.................................................................................hs.....h..........sp..h...s....hth....ph..s..s..s..............................................hp..l..s.....p..s.hphphsht..ap...sps..hps....................p.........................................h...t....h.psh.hh.hshulp+shhc.c+.hslslpssDl....Fssp...p.pt..tpht....hss...hhp....p.....ph...pspt.hhlslsY..pF..spt+	.....................................................................................................................................................................................................................................................................................................................................................t......................................h.....phthp.a..p..h......s.p.......p..tl.th.......th..t.h.t..htt....pt....t..........................................t..t........................................................tttt..t.......pt...thp.hsh..h..p...t.....p.h........s.......tt.....p....l..s..h.........sh..p......h...th...pp...pp...............pp........htp.........h......................................................t..........pps.................pt..p..t....p...h......t.h.p....hs....a....p......hs......h...s........p..............h....pl...ph..G...hp.h.p...h..p...p..pp...s.s.h........h.....ht...............tt..................................................................................................................................................................................................................s.......t.......t...s.s.p...........h..p..h...p......p...p..h....h....shah..p..hp.....h...p...h...........s...c..........h..s..h....ps..G....l+....h-..........s.p...h.....................................................................ph....p...................................t.t.........p......p...............................psh...h.....p......hh....P..sh...p..l..p..a....................phspp....p....lp..hs.a..sp......p..........ptPs....h........t.........p.........L.........s.............s.......h...........h.................p.......h.............t.........s..........s.......h..........p..............h............p.........t.............G..............N............P......p......L..cP.......p...hspshpls.........a.....p..a................p..pt..........h........hs......hsh...thp........pst...........................h....t...h.h...........................t..ss..............................................................................................hh....hh..p.....t.....N......h..s......p.s...pp.....h....s..hp..hsh..sh..ph...............tph.....h...p.h.p...........h...sh...s...h...t...h..p..p...p....s...................p.......t..................................................................................................................................................................p..........p..t.....s....h..th.........ph.....s.sp...............................................................................................hp...h....s........t...s......h....p.h.p.....h..s...ht.....hp........stt...h.s.....................................................................................................h..h...........ps......h.h...h........shs..lp.h..p.......h......h.p....p........p....h.....p....l.....p..l..p..sp..s..l........hp......pt.......h..h.......p..h.......s.t...............p.............................tp.....hhlshpYpht....................................................................................................................................................................................................................................................................	0	234	513	586
+14757	PF14906	DUF4495		Domain of unknown function (DUF4495)	Coggill P	pcc	Jackhmmer:Q8IV33	Family	This domain family is found in eukaryotes, and is typically between 322 and 336 amino acids in length. There are two conserved sequence motifs: QMW and DLW. Proteins in this family vary in length from 793 to 1184 amino acids.	25.00	25.00	28.60	36.10	21.80	17.90	hmmbuild  -o /dev/null HMM SEED	322	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.16	0.70	-5.48	10	82	2012-06-12 11:20:08	2012-06-12 12:20:08	1	3	65	0	58	84	0	292.90	43	32.31	NEW	scFVpllsKsAsplLE+L+plupEslc+AsLssL.....pusLuuAuhV+NpLhpYsphhp.......ssscpshlphSYcpYpEhsEuLsEpllDhHsRlluhhILQDADShaW-s.+sFaEGERCSFsIQMWaaYhpuh+pDLWshlPPKhAQ+lhAuMLp-SLolLosRYoQupPShsRosQlhlDIsslLLCosphLhSlCsoupchlss........p.sspSKIh+.IHs+CspLhssLllcuoPLssLYKlF++Gl-.shs....hhpspttpPs.Wlhhh...hPsLhp...........hchoslssshAlplpLKlLLuQPpssWsLLL+lLLM+cshls+lLL+pohps	..........................s.pFVphssKsAstlLp+LpchupEs.s.+AsLpsL.....pshLusAshVhpphtpYpphhp.........pspKpshhhlshppYpEhhpsLt..plhDhpsRlhuh.ILQDA-ShHW-Dh+sFaEuERCSaolQMWaaahhuh+pDLWshlPP+hAQcIhuphLpcoLulLssRYspspPShtRosQl.hhDlsslLlCstphL....hulCpSs..pthls...........p.tspspIh........+.IHs+CppLhssLllhsuPLs...LY+sFpcGhc.shp.......hpshht.PhhWl.hh...hPphht............................ss..ssphshp.hpL+lLLupPtssWsLLLcsLLh+DshLhpIll+p.h.t.............................	0	15	19	38
+14758	PF14907	NTP_transf_5		Uncharacterised nucleotidyltransferase	Bateman A	agb	Jackhmmer:B0MX79	Domain	This family is likely to be an uncharacterised group of nucleotidyltransferases.	24.60	24.60	24.60	24.70	24.50	24.50	hmmbuild  -o /dev/null HMM SEED	249	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.51	0.70	-5.04	171	654	2012-10-02 22:47:23	2012-06-12 14:18:15	1	9	531	0	265	712	105	226.80	16	64.96	NEW	ssh-WpplhphAptpplhshlhpslp.phs...........................hss...t....tlht.ph...ppt..hptsttpshthttchtclhphh.ppp.sIpslhLKGhsl..u.p.hYs..sst.h.....RthuDlDlLl........pc...hp..c...........................s..pp..lL..tph.Ga.p..........h....p..t.....p.......................sp.p.....................................cth.a.h.p...........................ps..hh...lE..lH.ap....lh............t.t.h.........ph.h.....p.....p.h..htp...................ht..h...ph..ssps...l.........hshs..spchhla.hhhH.h.h.c...H..h.h.......t..........tth..sL.RplhDl.thh.lpp.........h.pp.h.........-..apt....lh.pphpchshtc.hhhhshtlspphhs	.................................................................................................p.......hh.....tth.shh...h........................................h..................h.....tt..h.tthtplh.phh.ppt.slthlhlKGhsh...s..t.has...p.t.h.............R..hsDlDlllt.....pc..htp...........................s.tp.hL.tph.Ga.p......h..pt....t......................stp...............................................p..hhht.............................ps...hh...l-..lH.ap.......lhtt.............h.........t..h.....s.....p.h..htp...................tp..h..pl..sstt...h.........hh.hs.spphhl..h.h.hhH.h...h..p...c...h.h.t............t..tl.p.lhDlth.h.hpp.........h...p..h....................................s..hpt....lh.thhpphth...h..hh.h...........................................................................................	0	93	196	230
+14759	PF14908	DUF4496		Domain of unknown function (DUF4496)	Coggill P	pcc	Jackhmmer:Q6ZN84	Family	This domain family is found in eukaryotes, and is typically between 134 and 154 amino acids in length. Proteins in this family vary in length between 264 and 772 amino acid residues.	28.50	28.50	28.50	31.20	28.40	28.30	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.37	0.71	-4.29	29	151	2012-06-13 13:08:07	2012-06-13 14:08:07	1	19	72	0	104	143	8	135.60	24	18.56	NEW	lpplWpslspalpcplttp+uVplsshGsFohph.p.th.s........................tcPsFllsccFhppaslpttp........t...........sptssspl.sasplu..ttsshs+-.hlcsslccllptluctlp..stpsl.plsh.ulGpLph.+spplphpF	.............ptlWtslupalpcpLthp+GVpIsshGsFohpppphphsstph...................hhhp+PlFlhsccasptasLpps+h..........s...............................schshhtl.Nastlu..hts.s..hs+c..slcsslcchlthluctlp..................ttpsl.phsh.ulGhLhh.+spphphpF................................................	0	55	65	85
+14760	PF14909	SPATA6		Spermatogenesis-assoc protein 6	Coggill P	pcc	Jackhmmer:Q9NWH7	Family	This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family has similarity to the motor domain of kinesin related proteins and with the Caenorhabditis elegans neural calcium sensor protein (NCS�2).	27.00	27.00	27.20	27.10	26.50	26.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.66	0.71	-4.13	17	142	2012-06-13 13:52:55	2012-06-13 14:52:55	1	3	68	0	70	133	0	124.80	47	36.03	NEW	tl-Lpl+AVT..CPGVaLss+sclYLslplhGpahcTpshPshFPlLhp-+hpFEKsFhsssssupls-hLcschlhlELlQhssss...GplLApapsssRDFLaPtsphhssh.sGssR-lLMcpo......sFPG.I.uPKlEFSTcosI	.................h.ltLplculo..CPGVhL.s+p-laLulhlhsQYhcTpshPssFPlhhpppMhFEK...lF.pAlDPusVsphLE..hhhhELlQls.ss....u-pLAhY--NTRDFhFPtPp.hsua...sssRpVLM+ph......uFsG.I.APKlEFSTposI..........................................................	0	16	20	34
+14761	PF14910	MMS22L_N		S-phase genomic integrity recombination mediator, N-terminal	Coggill P	pcc	Jackhmmer:Q6ZRQ5	Family	MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication.  MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse [1]. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants [2,3]. This family is the more N-terminal region of the proteins.	27.00	27.00	27.60	27.10	23.60	21.00	hmmbuild  -o /dev/null HMM SEED	704	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.34	0.70	-13.29	0.70	-6.29	4	99	2012-06-13 15:05:30	2012-06-13 16:05:30	1	8	63	0	55	96	0	462.00	36	57.13	NEW	PPCFoCsa-.sppss.phSupuYLusGuLKRllL+LDPtPssF-tDsl-lFuFtWVTETALVESC...phLFsLhRQQlhpLEsLlQ..SpDFGpAAoLHscA-plRpQClhFLHYlKVFIaRhLcs.ps.sc.tshHPacchEAQLPShLV-EL+uLhLhIG+lssLPussluAF.s.Q+QsKlFPPSWHLLHLaLDhHWLVLEILHlLuc+h.tQVVYuppFls.sG-sLTNlSLFEspsEpLhsDLIsLuhp+YsKV+PoEsLpopHa.CpCsKELWlLLI+LLtaRsKh.tsc..sFWshlNKhLpolhcpsostcp.suhuhspsKDPhuFohWlhsHLApLhpasRpG..ss-cpKQhEsNWpFltpLLKp.lssQsuh.EEQlRhaLpCCLoL.sphWpPNlSVlThLWEYYSKNLNSsFoVsWLsLcGLssIs+osLuhLphs+sCCSc.....pphssLY+ousSahIFLpILA+hlK...cpuGspPW+QlKGRIYSKFHp+RM.ELoEsGLppFhpLFLlL.AtsAElEDlAS+lhDLLthLs.suhs.supRALlW+GphAhLLlYspKsLDlushAEKLustFpptA+EFh..Ks.-.sp+.sLWslluhYl-GVQEVFETSssLshSEE+LLN-GFuhLLPACRpuELspVLsFLQsVlARLRpVHppsuQs.p..sss..s..s.sAKE+..A.VAuALWpHFFPaL+SQRho	............................................FpC...t..tt.t.....h...tualtpG..h.ph.....t.c....thp.t..ph.th.hVtphhhs.ss...p.Lhthht...tp.....p.hp........s.hsshp...th...phRp.psh.Fhphl....h..................................h.hctl..tl...hsp..th..s......hh........h..................................................................hh.hu...att........-..h..t.h.C.C.+EhWlhl..hh........tp....sFWthhpphhpthhpt....pt.............shs.htF.hWlhhplu.hhpa...sppG......pp....hpht.ssh..htplLKp.hss......ps......Ep....phRhhl.hhhsL.hthhps.sh....shls.LW-Yap+pL.N.ssFslsh..hptls.h.poshshlc.hpphhs.......t..pL.....sSahhalhlLuhhhp....ttstst..hpp..lhGRlaSKFptt+h.tLsE.Gl.phh.LFLhl..ht..-hp-lss...+h...hp.hL..h....l....t.........pt..lh.h.+GphuhlLha.p+thshsshsthh.t.thtthtp-.................hthhs.ahtsl.pplhphu....ph..upphLl..s.hhshhl.tst.sp.p.hhphlp.lhtplp.........................................................................................................	0	17	19	36
+14762	PF14911	MMS22L_C		S-phase genomic integrity recombination mediator, C-terminal	Coggill P	pcc	Jackhmmer:Q6ZRQ5	Family	MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication.  MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse [1]. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants [2,3]. This family is the more C-terminal region of the proteins.	28.40	28.40	48.30	29.50	27.70	25.90	hmmbuild  -o /dev/null HMM SEED	373	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.89	0.70	-5.40	15	86	2012-06-13 16:19:41	2012-06-13 17:19:41	1	7	62	0	52	90	0	316.60	36	35.01	NEW	EplscLTphVhpLsEh+plh.cus.....hhpss+-PLstFFcAlG++hpp.cssuc..h+hphspKhcsYlscF-pWlsss...tp.ssthhpRhYshLulllhpCuslhYs+SKusChh+hhhs+hLLP.opLQsspsspspllpsl+KhaPllLQGlu...phsapsDsYLscpLcsllp+asP+Fhhsossthss+........h..hhpsss..spcLspalLppltspFlplpp.stsss+suhlLsllppLlcsh........pspsplhshlchltsulL-plhhVs-...s+thshslhphlVpssphppusts+pphssslpuhscKaLuhsTh.YFphLtcLAchsPclVtsLlspl+pplppsEhKRGsGcDsulRcsLpRLpssLp	......................................plhtLTphlhpLsEhctlh.cst........ssppsLh.FhcAlGhpattlQshu-...+oshspKsLpYlGclhKalpP.L..........tph.stuLplsYthhGhlVKphu.lhhT.SKuQpLLapllDsLLLP.s.Lppppt..s.hhpulpcsLPlaLQGhs...p.s.s.ssYLpphLtpllppYhs+FlsuSs..s.sht...............l....htsssss.hs....tLp+hllp...hlpcsalphcu.ptssP+LuslLsFl.pLhcc...............ps.tht.lchlLPulLcClhhV..s.......psps++hus-.lphhVpssp...htspttstsphsulhRpFlpcahhhashplaplLcslAhLs.plVhtLlsplppsL+poEhKhGlGcshu.Rpshp+L.shL.s................	0	16	18	33
+14763	PF14912	THEG		Testicular haploid expressed repeat	Coggill P	pcc	Jackhmmer:Q9P2T0	Repeat	This repeat is the only conserved part of the THEG proteins from vertebrate spermatids. Both human and mouse THEG are specifically expressed in the nucleus of haploid male germ cells and are involved in the regulation of nuclear functions [1,2].  Although the differential gene expression of THEG in spermatid-Sertoli cell co-culture supports the relevance of germ cell-Sertoli cell interaction for gene regulation during spermatogenesis, THEG was not found to be essential for spermatogenesis in mice [3].	27.00	8.00	27.00	8.30	24.90	7.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.71	0.72	-9.12	0.72	-3.42	37	329	2012-06-13 16:25:20	2012-06-13 17:25:20	1	8	58	0	222	470	0	51.20	24	50.06	NEW	W.......slspuALcupsopRlppLAp...P+hhtshh.hphs..................tls.tAhtht......sosRlhcLupPpp	......................................l..tshph.sopRltpLAp...PKhhtshh..tps........................l.................................ch..hs........................................	0	93	104	146
+14764	PF14913	DPCD		DPCD protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9BVM2	Family	This protein is a found in eukaryotes and a mutation in this protein is thought to cause Primary Ciliary Dyskinesia (PCD) [1]. This protein is 203 amino acids in length, 23 kDa in size and its function remains unknown. The gene that encodes this protein is a candidate gene for PCD and is expressed during ciliogenesis. PCD affects the airways and reproductive organs, and probing Northern blots show DPCD expression in humans is highest in the testes. Additionally, there is no indication of major splice variants [1].	27.00	27.00	43.90	43.60	20.80	20.10	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.13	0.71	-5.19	18	117	2012-06-14 09:39:13	2012-06-14 10:39:13	1	3	97	0	68	121	1	179.00	46	89.83	NEW	sWLshL+uAcKTullQDG+RKVHYpFsDGpEMAEEYDhcTspLlhR+WRpKusLGupGpWplElGEP.sssst..................psphlKEsuosPlFsR+sTKsuFpWRIRNLPYPh-sYoVTV-tcpRslllRToNKKYYKKhslPDLDRspLsl-pssLoasHtNNTLIIoYKKPcplLphEcplLpEL+KlKss..p-GDl	.................Whp.lpsupKoullps.G+RKlHahFsDGpEMsEEYDhcTspLLlRKWRhKs.s.L.Gu.upWplEVG-sss.ttss.h....................ssphlcESsusPlhhR.+DTKpuFpWRIRNLPYPc-VYuVsV-pcc....R....sIlVRToNKKYaK+hsIPDL-Rh.plsLcpstLSasHtpsTLIIoYpKP.tllt.hEppl.pElpplcstp....t............	0	26	31	49
+14765	PF14914	LRRC37AB_C		LRRC37A/B like protein 1 C-terminal domain	Coggill P, Hetherington K	kh6	Jackhmmer:A6NN04	Family	This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1) [1]. The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation [2].	27.00	27.00	37.10	35.00	24.80	24.60	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-10.91	0.71	-4.78	5	149	2012-06-14 09:49:06	2012-06-14 10:49:06	1	7	25	0	80	93	0	137.50	61	14.63	NEW	YPuLsSPG-QFEuQLNQQLRSLIPNNDVRRLISHVIRTLKMDCS-o+VQLoCAKLISRTGLLMKLLSEQQEsKlSKAEWDTDQWKTENYINESTEAQSEQKE.csSELsKEVPGYGYNNKLILAISVTVVVTlLIIIFCLIEICSHRRApcEDE	.....................................................P.h.SsGDQFEhQLsQQLpSLIPNNsVRRLISHVIRTLKMDCS-spVQls..CAKL....ISRTGLLMKL..LSEQQEsK.sSKs-WD.T-QWKoENYINESTEsQoE.QKE..c.sp.Eh...pKE.VPGaGYs.pK.LILAl.VTs..llhlLIIlFCLIp..l............................	0	13	14	15
+14766	PF14915	CCDC144C		CCDC144C protein coiled-coil region	Coggill P, Hetherington K	kh6	Jackhmmer:Q96IX9	Family	This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.	27.00	27.00	27.00	28.80	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.24	0.70	-11.93	0.70	-5.50	17	241	2012-06-14 12:50:39	2012-06-14 13:50:39	1	41	38	0	86	211	0	241.80	46	28.85	NEW	NphLQ-EIAhLRLEIDTIKspsQEKEpKYhEDIcIlKEKN-sLQ+slKLNEEsLTpTlhpYssQLNsLpAENTMLsS+L-pEKpsKERLEs-lESa+uRLAuAlpDp-pSQsoKRDLELAFQRs+DEah+LQ-KMsh-lSsL+DpNEhLSQQLScsEuKhNoLEhELH+sRDuLREKoLhLE..plQR-LsQsQsQtKEhEphhQsEpsKlsKahu.KQESlEERLuQLQSENhLLRQQL-DApsKs-sKEKsVhslQcphpshlppLQA-sEKpsLhLcE+NKELhsEssaLKERhhpYEpEKsERE	...............NphLp-EIAhLRLElDTlKppspcKEpKYhcDlchlKEKN-sLpKslKLN..EEslT.......cTh.pYstpLpsLp.s....ENshLsScLppcKps+pRLEsEhcSapsRLsuAlp-tppp.ssc+shclshppst-..hplptphs.chuth..pschLoppLScsctKhpsLc.ch+.sp-sL+EKoLhlE..psQp-LpQsQpphKEhcphapstpsphpchht.KQpsl-ERlsQlppcNhLLpQQL-DAppKssspE+hlhsIQtph........h-scKp.hhLcE+NKcLhschsaLKEphhpYEpEKsEp..........	0	26	28	36
+14767	PF14916	CCDC92		Coiled-coil domain of unknown function	Coggill P	pcc	Jackhmmer:Q96LY2	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.	28.30	28.30	28.80	29.20	28.00	28.00	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.03	0.72	-4.38	15	147	2012-06-14 14:55:10	2012-06-14 15:55:10	1	2	59	0	90	137	0	59.70	42	20.86	NEW	hpp+lpslp+slpFLQppHtpsLcuLHpEIc+Lpccs+-LpacLhhppssps.ps.ss...o.sp...ph	......ppplpshpKsL.FLQp-HusTLcsLHt....EIc+Lpp+spDLpacLhhppsppp..tps...t.t..t...................	0	25	31	52
+14768	PF14917	CCDC74_C		Coiled coil protein 74, C terminal	Coggill P	pcc	Pfam-B_23141 (release 26.0)	Family	This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer [].	25.00	25.00	25.40	53.00	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.53	0.71	-4.08	6	31	2012-06-14 18:18:57	2012-06-14 19:18:57	1	2	22	0	19	42	0	124.20	59	34.53	NEW	tPhMsL...P.tLRKPTTLQQCEVlIRQLWNANLLQAQELpHLKSLLEGuQRP+AssEE.........AGhuuP.+DQ-.....uppLPKVosKulSKKCLlLS.ssV.AE+uILPALKQoLKsNhAERQ+RLQAVQpRRlHRo	...................PsMhL...P..LRKPTTLpQCEVlIRpLWNsNLLQsQELQHLKSLLEGoQR.PpAsPEE...........A..S.P.+DQE.....AhphPKVoo.KulSKKCLlLSP.PV.AERAILPALKQThKNNFAERQKRLQAhQ+RRLHRS..................	0	5	6	9
+14769	PF14918	MTBP_N		MDM2-binding	Coggill P	pcc	Jackhmmer:Q96DY7	Family	MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle [1]. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner [2]. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells [2]. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4) [3]. It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920. 	25.00	25.00	31.40	31.40	19.00	18.40	hmmbuild  -o /dev/null HMM SEED	271	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.12	0.70	-11.66	0.70	-4.99	14	53	2012-06-15 13:15:41	2012-06-15 14:15:41	1	4	37	0	28	41	0	239.20	56	30.94	NEW	MDRYLLLVhWtEtKh.usAutEhE.ts-houhcsopppPclpAsNlYHLLKRSIosSlpP-DSTFPACSVGGhPGS+KWFFAlQAIhGFYQFCSSD..WpEIaFssEKDcIEDVLQTNlEECLuAlECFEEEDSNSRESLSLA-LYEEuAEsLHQLSDKLPAPGRAMlDlILLsSDKDPPKLKDCLPslGALKHLKEWaSAKITIAGsHCEhs......sQKIAEYLSAsVVohE-l+NsID..S+ELWRGcIQIhERKFG.ElSFPEFCLKGVTscNaSs.NLNo	........................................................MDRYlLhl.a.............t...t.s...t......s.hs.AsslYchLKcShssSlps-sSTFP..ACSVuGhPGo+KWFFAlQAIhGFYQFCSSD..WpEIphsspK-c.EDsLQTslEECLuAlpsFEE-DsNSRESLSLs-LYEEuAEsLHQLSDKLPAP.GRAMlDlILLsS-cDsPKLKDCLPslGALKHL+EWaSAKITIAuscschs......hQKIA-YLSAslVu.--LpNsID..u+ELWRGKIQIhERKFu.ElsFPEFCLKuloscpass.plp......................	0	3	5	11
+14770	PF14919	MTBP_mid		MDM2-binding	Coggill P	pcc	Jackhmmer:Q96DY7	Family	MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle [1]. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner [2]. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells [2]. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4) [3]. It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14920.	25.00	25.00	39.20	39.00	20.00	19.20	hmmbuild  -o /dev/null HMM SEED	342	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.09	0.70	-5.76	6	58	2012-06-15 13:23:16	2012-06-15 14:23:16	1	5	40	0	30	45	0	303.50	55	40.32	NEW	pcVFHYYGsALEaVQMVpLSDLPuhalSDhEFEL....uls++usKt.StLLL-QlsSLpGKVGALFsLsCslSslshPssuQLSS+KWREYhA+KPKsIsVPDVEVKGEpusYahLlQGsGsut...C+ATLlHSAoQINGuAALshlpuhl+.pscsupsuhshsshlpSLP+FsGEQllpRE+pLAplQsLALKEhLKR+ctsppssulsssELKuLLsLTREpaLchaDosLPcus..phtphpsshhlscsosssSspSstMcsNshEWPERpVLQNLENhEKhKQKhRsuhL.stSSEQLLG+KDG.R-ShTLLDAKELLKaFTs-GLPlG-LQPLplpRG..-sAF	................s.cVFHYYGPALEFVQMlpLSDLPShahS...DhEFEL.........sLo.ppss+tpShLLL-QlSSLpGKVGALFsLsColSslhlPsss.Q..LSS+KW+EYlA+KPKoI.sVPDVEVKGEpuuYYLLlQGsustt...CKATLlHSAsQINGuh..ALshlpG+h+.ps..ppuchu..hshc..lhSLPpFoGEQllpRE+pLA..pl..QsLALKEhLKR++hupQPps...lSssELKoLLhLTREpFLcha..-uhlPcss.....hp.hsph.ps..shlss..hs.ssp..sssSshhEsNs..LEWPERpVLQNLEshEKsKQKhRsu.......L.s+SSEQLLGHK-G.R..-ShTLLDAKELLKaFTsDGLPlGD.LQPL.lQ+G-psF.........................	0	3	5	13
+14771	PF14920	MTBP_C		MDM2-binding	Coggill P	pcc	Jackhmmer:Q96DY7	Family	MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle [1]. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilisation in an MDM2 RING finger-dependent manner [2]. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells [2]. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4) [3]. It is unclear which regions of MTBP interact with which binding-partner.  See PF14918, PF14919.	28.40	28.40	30.40	32.10	23.80	23.90	hmmbuild  -o /dev/null HMM SEED	251	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.59	0.70	-4.89	7	57	2012-06-15 13:45:35	2012-06-15 14:45:35	1	5	42	0	33	45	0	234.50	59	31.44	NEW	P-LoPcKL+tLPFEKAutC+YHGIEYCLDsRKALERDsGFuELQSRLIRYETQoTCsR-ssPlPh.......sLSPLPSPAVLSEPtSVPDGEuLQsElRs-sscLKRRS+DhssLhPtKRlsKScSSDSLlStsSssoupa.hshsoRp.puERshSs.............t.tlstpsuuuppssppocoopstKESRSQKHsRhLKEVVucTLpKHGIspcHtCFsuCSQRLF-ISKFYLKDLKTSRGLh-EMKKsAsNNVh.QVI	.............................P-LSPtKLpsLPFEKAusCHYHGlEYCLDsRKALERDsGFuELQSRLIRYETQTTCT..+EshPlPh.......lLSPLPSPAV....hSEPGSVPDGEsLQsEh.......+...sEsuRLKRRS+Dlssl..a.P...pK.RLsKSESSDSLlSQsSGsos....pptthsssR+.psER.Shuss.....s.ts.....pss+hspps.uuup+ssppscs......s+phKESR...SQKHTRhLKE.....VVscTL+KHuIsE...sHcCFsACSQRLFEISKFYLKDLKTSRGLaEEMKKsAssNsh.QVI.............	0	8	10	17
+14772	PF14921	APCDDC		Adenomatosis polyposis coli down-regulated 1	Coggill P	pcc	Jackhmmer:Q8NCL9	Domain	The domain is duplicated in most members of this family. APCDD is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo [1]. APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region.  The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling [2].	27.00	27.00	31.60	30.40	25.90	26.40	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.02	0.70	-11.74	0.70	-5.02	11	205	2012-06-15 15:05:53	2012-06-15 16:05:53	1	3	56	0	131	192	0	199.50	39	81.35	NEW	pCpp.hpclppts+lT.s.shPPcLcGpWlSppCEVRPGPEFLTRsYpFa..sNppF+AhQaYYsD.uCppPoaoLlI+Gpl+LRpuSWlspGATEA-aaLc+VsIl.HSppshp+lspclNpoCss.....h.s.spsWhPhh.YpLh....stpsppc............................ChsAhGFuhpELpLlRlppphhhps.........phspELaLGDIHTshspRtpYRPTuYQ.PLpsshcp.spsCPsCullh+uoEppPPlLPs	....................................s.tLpGpWVSptCE...VRPu........s.....FLTRpapFa.....s.N.p.oacua.aaYuDstCpp.PTaTlhs+G+hph..t.psShhlpGGTEhsaclp+spVssh.spsssphLsh.h.sp.oCuu.........tssWt.Gst.-lh...psp...t................................Ch.t.ulphs..hpEhpLh+hEpc...hhtp..................LalGph.TD.so..p..R...p..hRPTS...YQ.PL.ps............................s.............................................	0	27	35	74
+14773	PF14922	FWWh		Protein of unknown function	Coggill P	pcc	Jackhmmer:Q5TG08	Family	This is a family of eukaryotic proteins. Most members carry a highly distinctive, conserved sequence motif of FWWh, where h represents a hydrophobic residue. The function of the family is not known.	25.00	25.00	28.80	28.80	23.40	21.30	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-10.90	0.71	-4.74	18	109	2012-06-15 15:39:53	2012-06-15 16:39:53	1	3	49	0	68	108	1	146.90	32	28.93	NEW	l-htshsshcsschssLP...tplchpplhsplhcutph.tth.......................tt.ap.....................phh...Sct.tulhhDoFWahahctap.c...................p.phps+LFsRlApsYVplhhslt.sch+Dtahpha.phlApslahshhpsFPpuhphasps..F+tpLhphhhhhhoGlps..p.hphscWs	...........................................................................................................................hphstaptpc.stLP...ptlphpphh..llcupp...ph........................c.hc.....................pah...S.tshAlhhDoFWWhFhccapPs..................................................................................................c.QspLFcRIupsYstLhhph..s..sph.....c-...s.hhchhsshLupAlYssFppsFPpSh....Fssc..FKpslssph.hWho.GhhP..p.t.appW.........................	0	35	37	46
+14774	PF14923	CCDC142		Coiled-coil protein 142	Coggill P	pcc	Jackhmmer:Q17RM4	Family	The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.	25.00	25.00	31.60	31.00	23.70	22.20	hmmbuild  -o /dev/null HMM SEED	450	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.80	0.70	-12.52	0.70	-6.17	6	80	2012-06-15 16:15:37	2012-06-15 17:15:37	1	2	63	0	52	76	0	357.80	33	57.08	NEW	hLWsthGtuLsphh.............sslslas.shshslhphLppshspssLPppsppsLpsls+sLpppushpsWDpuFCtsLGSuspspsl.........th..sshuotTspLltpLF.PLlslLp......p..............sp.RspLhLphP.....LsRhlsTLpooplWlho+sppaLuuWuhspFLLllQ+DL.sLLc.......sscsLshLsps.......tshshslhspLstElp+hhscLptloccslplFot-C+KhoTphFp.sMPpG+aWR+chps-lPspPSpYAthsVppVLtPVlcGlptL.spAphsALopAloAhh-AWL-HILpccI+FSlpGAlQLppDFusVR-hlpuEp.uLStEh+QpLLSLclF+plDGAlhhLLpQPhsKptlscps....+pstsspsQshpplsoSS.LsSLcuh..psshpssl.ssp...s.................us..-.YhluNQQtWL	......................................................................................................................hWs.hu..L-..................lshh..pp.pthtp.L..p..s..splPp.s.ppLtsls.ctLhtpsh.htWDQh.Fp.ALsSu..tsps....................................s....so.Tsp..lh.p....lFssLlsh........................psp.slh..p.Ph....lthh.polposhLWhhtcupphhssWs.spFhhllppDl....hLp..........phpsLp.htpp...............lsltlcppLshElpp.hsplphhscEslp..lhup.C+p.uhtsFphhhPpupaWRhpltsp..stsS.Ysshslcpll.PVlpuhp......phshLs.hLphhhtAWLDHIhp+..tI+FSlpGAlQLhpDFssVRphlpp.phsLo.-l+ppLh.hplhpph-GshhhLLppP.st.plppp........pts.ptthp..p..thsst....s.............................................................................................................	0	15	18	35
+14775	PF14924	DUF4497		Protein of unknown function (DUF4497)	Coggill P	pcc	Jackhmmer:Q9P2G4	Family	This domain family is found in eukaryotes, and is typically between 107 and 123 amino acids in length. There are two completely conserved G residues that may be functionally important.	23.00	23.00	23.20	23.90	22.10	22.70	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.69	0.71	-10.21	0.71	-3.75	29	85	2012-06-15 16:57:50	2012-06-15 17:57:50	1	8	45	0	74	80	0	109.70	25	15.98	NEW	ppsph.pFppGKSCLFshsspslppphpshslph.shhch.s.h.hsss..ph.............lGsstlslsph......htpl..hpp........hp.p..................stu...cshcspasLhs.psp.ps.GplslhlRloshG..psl..lT	.........h..t..tFspGKSCLFphpsssLpptlhphPLth.hlhplsssh.hsss..pl...................lGssslslsst......hppl....htt........ht.p............................................sss.psh+spasLh........s...tsup.ps.GslslhhRLosLGppl.......	0	26	33	60
+14776	PF14925	HPHLAWLY		Domain of unknown function	Coggill P	pcc	Jackhmmer:Q9P2G4	Family	Members of this family carry two distinct, highly conserved sequence motifs, CPPPLYYTHL and HPHLAWLY. The family is found in eukaryotes, and the function is not known. This family lies at the C-terminus of members.	25.00	25.00	38.90	35.10	22.70	22.70	hmmbuild  -o /dev/null HMM SEED	640	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.98	0.70	-6.53	5	43	2012-06-15 16:58:46	2012-06-15 17:58:46	1	4	29	0	26	37	0	485.50	48	70.18	NEW	CSNuSSsRSVSPPNQEVTELDlETNIFCPPPLYYTHLTQEKsPPsQGKITIEPQINAPEELDGsFhEEcRVNPPTHTssLKHTsSAT+ESPPMLINPPHVQDlGASNQTTDHsQTEQNRINTIRQLPLLNALLVELSLLYNQPVASPTHIHPHLAWLYRTEDKKSPESSAKSTCKSESKKDKLShGGNEKSVSLQYKKNQsENLKKGKYFEKsSGAPPKRVPRGKLLYGLTNTLKLRLKQTNPDMLVVHEKREQYRKMQAQMLGTKLRIPSSKVKlLSFAEQaQKPHQLPKDKCLESDASFAENSDTSKQISGVlDDPSTopETKLKCATE.KTVDCuENRoNNGLLEEIVSPANSIVsE+FTsAsILEGKh..EMKVQSPsVFQQVAVVDRhlVDKEIDDKQVKTTDsDILTsD..ISEK+PSKNSCSESISELKYSDDFTSPCsSEDFsTSEDTSRILQAHDSSPGTENPKHSQaTSKSSETtLSIRKNSSEKSSILSPPFSAGSPVaSaKRFHISKTQDKSLEEASSISTSDLSSSHWTEEKENQIDQNSMHNSKVIKRDQ..DISlK.KTRTGCKSSEKSQSPRTSQVSSYLPSNLSELELNVLDSSTSDHFEEssDDlGSLNISKQCKDICELVINKLPGYT	........................Cssu.s.pslSs.spEVTELDhETNhhCPPPLYYTpLopEK.ss..spsphTh.sQhN.sE-h-sh..EpphlssPh..ps.ctspssspEpPshL.s.P.phps.utsspss...QsEQstlssIRQLPLLNALLlELSLLhsQPhsoP..splHPHLAWLYRs..E...D..pcu.P-sSsKuTspoEo.psKhshttpcK..sls.Qh+Ksph.p.s.pcs+a.EKpuus..p+Vs+t+LLYGLTNTL+LRLKpTNPsMLlVHEKRE.YRKhQsQhl.Gs.KhRlPSSKsKlhS..A.cQp.Qhs..QLPcDc.l.-ucushsEso-TStQlSssh-csSsocE.sch.p.h.shc.cplc.scs+hssh.lct..hsshtslhs...Ec.h.sshhtt.ph....ch+lpSPsl.tp.shlDp.hls..ct.hs.cplKsht.-..hus..hu-.p+.s.upsSs.EslSELpYSDDh.....s..S..P...CYSEDFsosEsou+....hpAhDSSst.....sE..sspps..phs..sKSS-splSh+csoS-.pSSlLoP..PF...SAGSPVpSh++.+l.Kt.pcpSLEEsSs.lS....sSDh........SS.pWTppKE....sph........Dpsuhpp....Sclh+psp....D.ss..psp.sshKS.EKSQS.pTSQVSSYLPSNlSEL-LsslDs..SsuschpE.pDplGSLsIocQCKDICELVINKLPGYT...................................................................	0	1	2	6
+14777	PF14926	DUF4498		Domain of unknown function (DUF4498)	Eberhardt R	re3	Jackhmmer:Q9BRQ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 308 amino acids in length.	27.00	27.00	28.20	28.20	26.80	26.70	hmmbuild  -o /dev/null HMM SEED	247	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.66	0.70	-5.23	16	119	2012-06-18 07:58:32	2012-06-18 08:58:32	1	3	86	0	74	116	1	184.50	36	75.31	NEW	sFs.LstpsFstl..pD+-lpchL.hKWulpsplphpsFpacpp...ap.shppschltsFFpDpsVtpsLpl.p.pssthst.lutp......ssclcsp.lssohhShsFFD+Lhs..su...IVR.psGc.Is+ChD-hh-sh.lSDELRchLL.EDSEpYclFS-s-RpEhLFcLFcpLlLG.GslCQaEDplpPYl-soKplYK-LVulpKsspT.cpIpls.StVa+Vsuh.s.pss..sh...ps....ssHtQshsYlllDPt+RclpllYH	................................................sh.t.phphptFtasp......................ap..hptpphhhsFFpcssVh.pLthh......ts..h....s.t.........stplph..lsso.hohshFppLhs....tsll+.tsGp.lhpChcp.h.tsh.hsDpLRphLL..........p..-S-papl.aop.-RpEFLFplFp+LslG.GslCQaEDslsPYL-ssKhlYKcL......Vu.......lp+ssps......p.......plt...............l..o.lhcV.sh........s.t.t..h....tt..........t.p.tshsahhlss.p+.h.hh.p........................................	0	28	36	55
+14778	PF14927	Neurensin		Neurensin	Eberhardt R	re3	Jackhmmer:Q8IZ57	Family	The neurensin family includes the neuronal membrane proteins neurensin-1 and neurensin-2 [1]. Neurensin-1 plays a role in neurite extension [2].	25.00	25.00	25.50	25.80	24.90	23.60	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.94	0.71	-4.80	14	169	2012-06-18 09:29:10	2012-06-18 10:29:10	1	2	52	0	110	147	0	131.00	32	57.78	NEW	haGVRuYLHpFY-..........-Cs.......suh.cppc....sh...hphssp+hsulhWKV.......ulssGhLlLlhGlssLhlGYh......lP.+hEhh.....s...............p.uph.hlDspAspaNpsLDsh+LsGssLhClGGlhlAhsLl..lsshtps.tcpE.hhpts.ppt.	.................................................................................................................hch...................uhlSuhlFLlhGlhllsluYh......VP.clcs......s....................p.t-h...hl-p...pu...s...phsutLDpChlAGhsLhslGGhlLushLh..hSha..ttp...............h....................	0	15	24	50
+14779	PF14928	S_tail_recep_bd		Short tail fibre protein receptor-binding domain	Eberhardt R	re3	CATH:1ocy_A_02	Domain	This domain is a receptor binding domain found on bacteriophage short tail fibre proteins. It contains a zinc-binding site and a potential lipopolysaccharide-binding site [1].	27.00	27.00	31.40	42.40	22.50	20.40	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.50	0.71	-3.90	9	26	2012-06-18 10:30:31	2012-06-18 11:30:31	1	5	24	2	0	30	0	119.20	54	23.35	NEW	ssstcIh..ss+GsDuKsKPtLGsGsuGhslGpVQtQQlphHKHAuGaGE...psssusFGsTspssalGoppt.DWDNtpYFTN-GaEl-us.pRsshsTLNocsLIGsEsRPWsMSl.aIIKV	.................ssGsHIh..ss+GpDuhGKsRLGsGCsGhhVGpVQsQQhpYHKHAGGaGE...pcspu...sFGsTstssYlGTRKthDWDNtSYFTNDGaE....lsss..RsuhsTLNpEGLIGsETRPWNhSLNYIIKV.	0	0	0	0
+14780	PF14929	TAF1_subA		TAF RNA Polymerase I subunit A	Coggill P, Hetherington K	kh6	Jackhmmer: Q15573	Family	TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilises nucleolar transcription factor 1/UBTF on rDNA.	27.00	27.00	28.30	27.60	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	547	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.84	0.70	-12.85	0.70	-6.06	13	157	2012-06-18 12:06:50	2012-06-18 13:06:50	1	5	65	0	85	134	0	250.30	21	84.78	NEW	chpsst-tpshpssstppchhhphhhshpt.shh...........pcs+hhplLpchlpp+pWspAushhpshlcsht+s.shpt..sc.hh.tlts-llhphsps.......huschpshuthhslhhpp..............h.....p.phhlhLppuLahlppsthttsshphoh......h.ppp.t.shpslhphahGLltYcpWhpsl.cph+hccpsh................phtts.hsppst....pps..........hspphspsshtsssspsslhphsts..................lDphlps.spthpFhpspcthcpsho.hs..E+hssss..t.h..............................................shaphl.+aL..+....uss.s........................hhlhutclp-t...hpp.s.sstssh.hchtshhhp.hs...ps.sshlhSslcchhphsPspphhl-+tphh+cp....hpphh-h...+hp.h.sp..hW..hs.sh.p.htphtp.tEcpppuhplhF.hLDauss+pN.pAWphhtphlpplhh.....saltppWcsRpsWW.saHFSp.h....h.p.......tts...chhspKAssAuhhhG.thtYh........p...hp.h.hLtcphpp.....p+lhpsh	..............................................................................................................t...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tt........................................	0	12	24	48
+14781	PF14930	Qn_am_d_aII		Quinohemoprotein amine dehydrogenase, alpha subunit domain II	Eberhardt R	re3	CATH:1pby_A_02	Domain	This is the second domain of the alpha subunit of quinohemoprotein amine dehydrogenase [1,2]	27.00	27.00	57.60	56.70	26.00	19.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.41	0.72	-4.10	20	36	2012-06-18 12:07:57	2012-06-18 13:07:57	1	4	31	4	13	43	1	108.10	38	20.58	NEW	tsssLsGpWsluG+hPG+G-apGsMolsuuut.DpYsVshsh+.aADGsshsupGsAllYTGYEWRAslslG...........ssshRQVhAhs..ssphpGRhF.tspDchGuchhAs+ss	..p.ssLsGpWshoG+hPu+G-hpGsMolssuss.DsYpVplchc.aADGsshsupGsAllYsGYEWRuslclG..........ssshRQVhAhp..suphpGRhF-sscDEhGhchpAs+t........	0	2	9	10
+14782	PF14931	IFT20		Intraflagellar transport complex B, subunit 20	Coggill P	pcc	Jackhmmer:Q8IY31	Family	IFT20 is subunit 20 of the intraflagellar transport complex B [1]. The intraflagellar transport complex assembles and maintains eukaryotic cilia and flagella. IFT20 is localised to the Golgi complex and is anchored there by the Golgi polypeptide, GMAP210, whereas all other subunits except IFT172 localise to cilia and the peri-basal body or centrosomal region at the base of cilia [1,2,3].  IFT20 accompanies Golgi-derived vesicles to the point of exocytosis near the basal bodies where the other IFT polypeptides are present, and where the intact IFT particle is assembled in association with the inner surface of the cell membrane.  Passage of the IFT complex then follows, through the flagellar pore recognition site at the transition region, into the ciliary compartment.  There also appears to be a role of intraflagellar transport (IFT) polypeptides in the formation of the immune synapse in non ciliated cells. The flagellum, in addition to being a sensory and motile organelle, is also a secretory organelle [5]. A number of IFT components are expressed in haematopoietic cells, which have no cilia, indicating an unexpected role of IFT proteins in immune synapse-assembly and intracellular membrane trafficking in T lymphocytes; this suggests that the immune synapse could represent the functional homologue of the primary cilium in these cells [6,7].	27.00	27.00	27.90	28.70	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.49	0.71	-10.40	0.71	-4.21	26	146	2012-06-18 12:46:22	2012-06-18 13:46:22	1	2	119	0	100	147	2	114.40	42	85.21	NEW	tGlahD-hs+lRVl-P-htspoppL+-EspcFlc+lspFpcllpphhphlcphA+cVEpEKl+AIGsRNhlcoh.scpRcscpQplQshItEKpsELERLpsEacuLp+lEpEQpphIpph	........GlaFD..-ls+lRVLDP..............-ssppT.cLK-ECccFlcKls...pFp+lVsshlcll-plAKc...sEsEKhKAIGsRNhLcSh.ucpRcsppQplQshItEKphpLERh+sEY-uLpKlEtEQpEhIpph...............	0	40	50	77
+14783	PF14932	HAUS-augmin3		HAUS augmin-like complex subunit 3	Coggill P	pcc	Jackhmmer:Q8IY31	Family	This domain is subunit three of the augmin complex found from Drosophila to humans [1]. The HAUS-augmin complex is made up of eight subunits.\	  The augmin complex interacts with gamma-TuRC, and attenuation of this interaction severely impairs spindle MT generation. Furthermore, we provide evidence that human augmin plays critical and non-redundant roles in the kinetochore-MT attachment and also central spindle formation during anaphase in human cells.The HAUS complex is required for mitotic spindle assembly and for maintenance of centrosome integrity [2].	27.00	27.00	29.70	29.30	24.90	24.80	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.64	0.70	-5.20	25	132	2012-06-18 13:04:39	2012-06-18 14:04:39	1	2	88	0	88	120	0	228.30	27	43.67	NEW	Wlh.ps.-phcpFhcWlspsls-sNlLo-p-Lppa-pLp.ppGc.lLcup-L-.sLpplpspsssh....ph......s..-......p-lctLcppltsl.tchpp.htpLh.schp.phcph.hspph...spLpspp...tcsstthptspph..ltsphpc+sppLpplp.pcssphsp-hpc.tp....ps.sslFlpQhslcpYhhps-phhphLshYh++pFpht.hchs..psssps....lp.......t....c.pc..th.ppp...ptELppLpptht.hsphpaIctcscs.p	..................................WhF.ps..-scsFLcWhCssls.ppNlLotpElpta.ppLp....cpG+.l.....L....-utsL-tsLcs......hps.s.ph.......ph...............p..-........................ppl-tLcpplpsl.tchpphphphh.pchp..hsph..tupp.....hplpscp......tpsstphppstth.......lps..sphspplptlhsplsphh......t...............h............pp......t.s...................pp...ssl...aluphsLcpYltp--p.ottLs.ahpKpFhpG.tchs..Essspppa......hD.hpt..hp.........cppc...hpcc....phEhtRL...p.ha.........h.huppphIphpsp...........................................	0	22	36	61
+14784	PF14933	CEP19		CEP19-like protein	Coggill P, Hetherington K	kh6	Jackhmmer:Q96LK0	Family	This family includes the centrosomal protein of 19 kDa found in eukaryotes. In humans, it is encoded for by the gene CEP19 which is also known as C3orf34. These proteins localize in the centrosomes. Centrosomes are dynamic organelles that assemble around the centrioles. They organise the microtubule cytoskeleton and mitotic spindle apparatus and are required for cell division and cell migration. C3orf34 localizes near the centrosome in early interphase, to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase [1].	27.00	27.00	27.00	28.50	25.00	26.50	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-11.02	0.71	-3.94	20	94	2012-06-18 14:37:52	2012-06-18 15:37:52	1	4	74	0	64	86	0	149.40	38	67.25	NEW	++sGlRhpPPslllhYpsp....ssKhRpRh....lPl.Rshppposssths-cLtpp.......s++psaLpplsphQlc.........+hhphL.........................psphpuhshspshpthtpctsls................pcDLNKlDDppLpctKstM-ctFc+Npl+PGDssFlYDhcl-Fspsc..psSuWD	....................................................................++sGl+hpPPslllhYppp....ps+.RpRh....hPl.pshpp.Sss...sphAEpL+ps.......s+H+sYL..pplshtQlc.........+lhphL...............................................................................................pshhpGpolspshpphppctsl-..................s-cDLNKLDDcELt+pKshMDEhFc+Nph+.sDPsFVYDlEl-Fspsp...pssuWD................................	0	32	38	48
+14785	PF14934	DUF4499		Domain of unknown function (DUF4499)	Coggill P, Hetherington K	kh6	Jackhmmer:Q8TBM7	Family	This family contains a protein found in eukaryotes. Transmembrane protein C10orf57 is encoded for by the gene chromosome 10 open reading frame 57 (C10orf57) located in chromosomal position 10q22.3. The exact function of this protein is still unknown, however it is thought to be an integral membrane protein. The protein sequence is 123 amino acids in length and has a mass of approximately 14.2 kDa.  The family also includes some longer proteins that possess an N-terminal dehydrogenase domain, Pfam:PF01073.	21.90	21.90	22.60	24.90	21.80	20.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.06	0.72	-4.04	28	133	2012-06-18 14:45:52	2012-06-18 15:45:52	1	4	93	0	76	130	1	88.90	31	42.66	NEW	luhshahhslFtsstlPht.lGPluhh...hchhlhpphpllphsahhAhllHlsEAlYAhhLs+ptsl.csssphtWFlQThlhGasSLplLlc	.................................................h..hshhhhslFhst.lP...lGPlu.h...sphl.l.p.phpllp.hsahlAhllHl.sEulYAhhLC+cp.sl.sspsphhWFlQTFlhGhsSLslLl.t........	0	30	43	54
+14786	PF14935	TMEM138		Transmembrane protein 138	Coggill P, Hetherington L	kh6	Jackhmmer:Q9NPI0	Family	This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells [1]. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.	27.00	27.00	31.60	31.60	23.70	23.40	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-10.53	0.71	-3.78	16	91	2012-06-18 14:53:30	2012-06-18 15:53:30	1	1	76	0	59	79	0	117.90	48	73.53	NEW	stllLFllQDssIlhshlllhLshauTaVaQsGhsplLlc+F+hhlllsslYFhLSluhHhWlls.hRh..tssspa.Ws.pGLhALaVlQRlsSVhYYYhYKRTALphuDPRaYc-pl.Wlpcph	.................lQLVLFIIQDlsllhslIllhLhhFsT...aVFQuGLlsLLh++F+ssllloslYhsLSIulHsWlhs.lRW.....pssspalWT....cG.LpsLFVhQR...l....uAVlYaYhYKRTAlpluDPRFY.pDSh.WLRcpa......	0	14	19	40
+14787	PF14936	p53-inducible11		Tumour protein p53-inducible protein 11	Coggill P, Hetherington K	kh6	Jackhmmer:O14683	Family	TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis [1]. The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation [1].	27.00	27.00	37.90	37.60	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.50	0.71	-11.27	0.71	-4.33	6	94	2012-06-18 15:01:03	2012-06-18 16:01:03	1	2	50	0	42	69	0	143.60	62	78.27	NEW	MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQlLGNEIKFAVREPlGLRlW.hl...SAslFTulAlMALsFPsQLY-sVF-pt.s......oo+lSlRLYGGALLSlSLIhWNuLYTuEKVIIpWTLLoEACYFulQhLVTolT.LlEhGhhu.us.llLLluRlLFlhlolsYYYhLGR+PKK	..............MKKHSQTDLVSRLKTRKILGVGG.E.DDDGEVHRSKISQVLG..NEI....K.....FsV.REPLGLRVWQFl...SAVlFou.lAlMALsFPD..Q..LY-sVF-tups......sSc.ssl.RLYGGALLuluLlhWssLhssE.+s.IphsLLspAsaaulQhlV..................................................................................................	0	8	11	24
+14788	PF14937	DUF4500		Domain of unknown function (DUF4500)	Coggill P, Hetherington K	kh6	Jackhmmer:Q96KF7	Family	This family is found in eukaryotes. The function of this protein remains unknown. The gene which encodes for this protein is named chromosome 6 open reading frame 162 (C6orf162) and is found between the chromosomal positions 6q15-q16.1. It is thought that this protein may be an important part of membrane function.	27.00	27.00	28.20	28.10	23.50	22.50	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.05	0.72	-4.15	16	85	2012-06-18 15:12:04	2012-06-18 16:12:04	1	2	73	0	57	80	0	83.80	51	80.74	NEW	ppsps.t...htusGlRSl+TToLFRAlN.ELalKPNKslMuhGLlAlohCsGYluYM+sph-spp...hYsAlcuDGpc.hh..+KpS+W	..........h.....pcpshtssGLRusRTToLFRAVNPELFlKPNKsVMAFGLlsloLCVuYIuYhHAppENcp..pLYEAlcS-GcphhR..RKoSKW.....................................	0	13	18	35
+14789	PF14938	SNAP		Soluble NSF attachment protein, SNAP	Eberhardt R	re3	CATH:1qqe_A_00	Domain	The soluble NSF attachment protein (SNAP) proteins are involved in vesicular transport between the endoplasmic reticulum and Golgi apparatus [1]. They act as adaptors between SNARE (integral membrane SNAP receptor) proteins and NSF (N-ethylmaleimide-sensitive factor) [2]. They are structurally similar to TPR repeats [2].	25.00	25.00	25.00	25.00	24.90	24.90	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.82	0.70	-5.26	62	864	2012-10-11 20:01:04	2012-06-18 16:23:28	1	81	388	5	519	1551	81	229.00	25	66.89	NEW	scupplhtc.A-KKlpsstuhh.uhF..Gupp.KaE-Au-LappAANtaKlsKpaccAGpsah+uAcsphc.hsspc-AAssas-AucsaKKs........ssp..cAlpsLppAlph.asctG+appAAcappclAElYEp-........tD...........hcpAlcs..YcpAu-aaps-p.usutANpChlKlA.pl.uAphp..pY.cAl-laEclAcpSlsNsLhKaSlKcYaLpAuLCpLsts.DsVusppuLp+YpchDPoFssoREt+hLtsLlpAh-ptDs-tFosslh-aDpho+LDpWKTolLL+lKpslp	.....................................................................t....th.tp.Ac+hhp........th.h...................chcpAsphatpA.As.ha....+...h......t..+p........hppAs.psa...hcs.A.p...hp.....p....hp...s....................c...A...A.......p.s.h..h...p.Au......p..s.h.+ch.................s..p...................cA.l.p.h..l...pp.Al....ph...Y...t.....c....h...G...p...h.p.h....A...Ap.th...........t.plAc...........lhE.s....p......................c...................hccAlp.h..Ypp.Au..-....h....a...p..t...-p.......pp....t.......t...A.s........c...hhh....+...sA............p...h...hs.p.h...p.................pY.pcA.h.ph.a.c...p.......h......tt.......h...p.p...h...h....p.....h..s..h.+..t......hhhtt.hl.s...hh.......h..................D.........h.....ts........p.shp.ph...t.....tF..t.oc-ht.h.httl.htuhc........pts......................pthtphh......................................................................................	0	197	301	426
+14790	PF14939	DCAF15_WD40	ShortName;	DDB1-and CUL4-substrate receptor 15, WD repeat	Coggill P	pcc	Jackhmmer:Q66K64	Repeat	DCAFs, Ddb1- and Cul4-associated factors, are substrate receptors for the Cul4-Ddb1 Ubiquitin Ligase. There are 18 different factors, the majority of which are WD40-repeat-proteins [1].	23.90	21.80	26.50	23.10	23.70	21.70	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.46	0.70	-4.98	11	84	2012-06-18 15:44:06	2012-06-18 16:44:06	1	3	69	0	57	80	0	186.10	44	29.51	NEW	stppptphFp+.lPs+lplsLKslls.s..LhsGHlFLGhTKCGQaLLSYoh.h-h-ss.h.....sshY+YcLaWWpFpP...........+ppLpKltpVpLFs-c..tlsstLplslspW..sDpppllVaG..hp...........susc-spcsYlTlssVPsls.Cp-C+plssu.............ssh.hp.....CLcHshTlHopYpllsPaPsFpPplsLppsshlllNoushlhsLplplshsc	...................................u.tphp.phFc+.lPsRlplsLKsllsps...LhtGHIFhGFopCGpYlLSYssssssss...........shYhYpLYaWtFps...........+p+L+hltpVRLFpDc............tl.splhlo...lspW..sDtphllVaG...............husEspcDhYlohVsVPs.s.ChtCpchspstsh......................ss..up.......CLpHuahlHTKYpll.PaPsFpPshpLppsphlLlNTuh.lhshtlslcs.st......................................	0	18	22	39
+14791	PF14940	TMEM219		Transmembrane 219	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NWD8	Family	This protein belongs to a family found in eukaryotes.  Proteins in this family are typically between 240 and 315 amino acids in length. The domains in this family vary in length from 202 to 249 amino acids. Its exact function remains unknown, however, it is thought to have a role as a transmembrane protein. More specifically, it is possible that this transmembrane protein may have a role as an insulin-like growth factor binding protein 3-receptor (IGFBP-3R). This receptor binds to the ligand, insulin growth factor 3, which is a p53-induced, apoptosis factor important for cancer prevention [1].	27.00	27.00	28.10	30.70	24.60	24.10	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.37	0.70	-5.25	9	99	2012-06-19 15:03:32	2012-06-19 16:03:32	1	2	50	0	54	95	0	210.30	46	75.39	NEW	L+salspRPPhVlFhlslhshAluhlsLuhah..phptlpsPDhspDWNphLhphuphcFCs.........tpstshphhhs-oss....................hpspsshslolshhLsls.hhs.sGhspNhsh.lpusltGpplGLpGt.utEplNlTFpLsssh....s...sth..sphtTChshoAssplhPsoh.PPpC.spphssssh.p.hhhsh.pp...........hshpsssh+lhps.sPcLTVhl	....L+lhlup+PPLVshhlsl.hhuluhLsLGhFh..+hptl+SP-hspDWNoFLhpFspLcLCs........................ps.s.t..hN-TsT.....................................hc..ppGPhslolhhTLsls.....sG.sR.NhT+.l.uTlhGpQlGLpGppApEplpIThplsssh..................shsTChshoAssslhPso..P.pCss-shuNATL...h...hs.................s.ttthhphh.t.p.hLo.hl.............................	0	11	15	25
+14792	PF14941	OAF		Transcriptional regulator, Out at first	Coggill P, Hetherington K	kh6	Jackhmmer:Q86UD1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 198 and 332 amino acids in length. The domains in this family vary in length from 239 to 242 amino acids. The gene, OAF (out at first), which encodes this protein, has a promoter which may help mediate regulation of neighbouring genes [1]. An alternative name for this protein is HCV NS5A-transactivated protein 13 target protein 2, which stands for Hepatitis C virus nonstructural 5A-transactivated protein 13 target protein 2. NS5A inhibits double-stranded-RNA-activated protein kinase (PKR) activity, which is thought to allow Hepatitis C Virus replication to continue in the presence of an alpha interferon (IFN)induced antiviral response [2].	27.00	27.00	56.30	34.30	22.70	22.20	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.66	0.70	-5.22	7	85	2012-06-19 15:11:22	2012-06-19 16:11:22	1	3	68	0	59	91	0	210.50	50	81.54	NEW	u-L+VpVRLsDGQVTEEsLpADSscDhIoLEF+psDGTLITalADFKp-VKIFRALILGELERGQSQaQALCFlTRLp+NEIIPSEuMA+LRQKNP+slRpAEEhRGhEphoMslAVNho+uhQLSsHI+NlCuEA+-AlYTRctDV+aWL-+.....Gh-uShFEhhPpsuphssLppCppspDhWpPClCoYsLsLEWYPChLKYC+uRDs..+s...........osYKCGI+SCpKuYpFsaYVPQKQLCLWDE	................................pLhl.Vp..sGplhpEslpus.stD.IoLEhp+sDGTLlo.hhDF+p-VpIh+ALlLGE.E+GQS..QaQshCFlT+hp+s-hIsS-AMAKLRQKNP+slRpAEEs+GhEphpMsshVshopuh.lS.HlpslCAEAh-AhYsRptDl+hWhEp...............us.tus..hEhhPp.s...........p...................RCtp...sushhtPClCphthsluWYPChLKYC+u+s....ts.................osY+CGI+oCpKsapFsaYV.Q+Q.CLWDE.....................................................	0	16	21	40
+14793	PF14942	Muted		Organelle biogenesis, Muted-like protein	Coggill P, Hetherington P	kh6	Jackhmmer:Q8TDH9	Family	The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms.  The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system [1].	26.00	25.70	26.00	25.70	24.70	24.50	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.90	0.71	-4.32	11	90	2012-06-19 15:23:15	2012-06-19 16:23:15	1	3	76	0	64	85	0	139.90	38	76.07	NEW	llKDlGEIaSRLLDHRPVlQGEI+YFl+EFEEKRuhRElchLEslpphlsEhsEchLP+CppshpspLsplhppLpsAssslp+Lpp+EpcpcK..uspLpsucctRptcWEcFhp-Qpp+ptcVDcEaccthc+lpEQYs-hc+cL	............lh+DlG-IaSRLLDHRPllpGEh+aFlKEFEEKRGhREh+sLcslpphlpEosEphLP+Cpcs....h....p......cpLsp..lhp+L.....psAscslp+Lpp+Epcpcc....sspL.tsccp+ptpW-cFhcc.ppcptclDpEacct.ccLp-pYschphcL.................	0	21	25	44
+14794	PF14943	MRP-S26		Mitochondrial ribosome subunit S26	Eberhardt R	re3	Jackhmmer:Q9BYN8	Family	This family of proteins corresponds to mitochondrial ribosomal subunit S26 in eukaryotes [1]	27.00	27.00	30.40	29.90	26.10	21.90	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.00	0.71	-4.70	24	113	2012-06-19 15:32:32	2012-06-19 16:32:32	1	6	90	0	71	118	0	151.90	34	68.71	NEW	KPRalPsAKSKhaRVspts.hs.-EhhELpchappY+sthpulRphhp...cEshppphpscssplh.p..cppcE....pEapphhthN-phNtcltchREtRlpcEpEcpcphhhcphhtcppcppphhcptEppVhp.p....EpuKoFITtENLDptIEcALssPssYNaAlDhpGslh	..................................KsRa.PsAKSKhhR.l.h.s.hsstEhh.lhchap..pY+phhpul....Rt.ht...pElhppt.pspss.thh.p.pttpp......pEacplhshNctcNtchtphR.tRlppEtccpcph.hpphttctpctpthhppt-pcVhphp....EcuKsFITtENL-ttIEpALs.s.P.hsYNaAlDhpGph........	0	23	29	52
+14795	PF14944	TCRP1		Tongue Cancer Chemotherapy Resistant Protein 1	Coggill P, Hetherington K	kh6	Jackhmmer:A1KXE4	Family	This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length [1].	27.00	27.00	109.60	30.10	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.01	0.71	-11.41	0.71	-4.37	3	109	2012-06-19 15:33:00	2012-06-19 16:33:00	1	2	39	0	56	76	0	203.30	71	99.36	NEW	MNPVYSPuSoGVPYuNsKGMGYPAGFPsGYAAAAPAYoPNMYAGuNPAFs..........................P..........................................GYTPGTPYKVSCSPooGTVPPYSSSPNPYQTAVYPlRSAYPQQNPYA.......QQGAYYTQPLYAAPPHVIHHTTVVQPNGMPAAMYPAPIPsPRsNGVAMGMVAGTTMAMSAGTLLTSPpPTPVuPHPVSVPTYRPPGTPTYSYVPPQW	.....................................MNPVYSPspsGsPYuNsKshuYs..GaPhuYsAAAPAYsPshYPsssPoat............................................s................................................................tYT.sGTPYKVsso.osuAsPPYSsSPNPYQTAhYPlRSAYPQQN.YA........QGsYYTQPlYAA.PHVIHHTTVVQPNuhPu.slYPAPl..s..sPRsNGV.sMGMVAGTTMAMSA...GTLLTs.p.TslusHPVohPTYRA.GTPsYSYVPPpW.............................	0	2	7	23
+14796	PF14945	LLC1		Normal lung function maintenance, Low in Lung Cancer 1 protein	Coggill P, Hetherington K	kh6	Jackhmmer:Q9H1P6	Family	This protein is part of a family found in eukaryotes. It is 137 amino acids long in protein sequence length and mass is approximately 15.7 kDa. The protein is present in the normal lung epithelium, but absent or downregulated in most primary non-small lung cancers. The gene is known as Low in Lung Cancer 1 (LLC1). This protein is thought to have a role in the maintenance of normal lung function and its absence may lead to lung tumourigenesis [1].	26.10	26.10	26.40	27.30	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.69	0.71	-3.79	8	54	2012-06-19 16:02:06	2012-06-19 17:02:06	1	2	41	0	42	55	0	111.30	41	84.16	NEW	hVapDEIaKDHl++EptApKpWspcWGaLp..sphcclt-cpcchpss+s+lshtpcphhppLPPhcs.ht......tsuPPVPpTTuGhIGWRSupPphNLEhYt+aspstpsKGull+cLpWPpEG	.............................hVspDEI.WKh+l+sEpcAppsWsppWGFLs....sshcE.Llcpc.cc....s.sKPKlcLPp+......hplcPloPl-KYIKl.........hPSP.PVPpTTQGFIGWRSulPths.cphc+ptchtpCKGuas+cLpWPcpG............................................................	0	19	19	24
+14797	PF14946	DUF4501		Domain of unknown function (DUF4501)	Coggill P, Hetherington K	kh6	Jackhmmer:Q96HA4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 167 and 308 amino acids in length. The exact function of this protein remains unknown, but it is thought to be a single-pass membrane protein. This family contains many highly conserved cysteine residues.	26.50	26.50	53.90	26.50	21.50	21.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.12	0.71	-4.79	9	65	2012-06-20 08:49:22	2012-06-20 09:49:22	1	2	30	0	24	54	0	129.60	50	72.75	NEW	SotStuQpPECCsDss-lNuoCsGouLCGPGCYR+WstDGSuSCV+CtNGT.....shaNsSECRshuGRGhphPhN+SoGsPG..phGGPpVAASLFLGThFISoGLILSVAuFFYLKRSSKLPcVFYRRN+APlLQPGEsAuMIPsPQSSVRKPRYVRRERs.-psssPushSosEARlSNV	.............................................sp.sECCs-hhshNsoCsssshCuPGCat+htt-us.sClpC.sts..............................s.st.h.su.Gh.hshNpSossss....p.Gu.PpV.AASLhLGThFIS.hLILSVAuFFYLKRo..sKLPcl.h.YpRsKAssLQPuEsAuMIPs..PpS.SlRKPRYlR+-p.......................................	0	2	3	9
+14798	PF14947	HTH_45		Winged helix-turn-helix	Eberhardt R	re3	CATH:1r7j_A_00	Domain	This winged helix-turn-helix domain contains an extended C-terminal alpha helix which is responsible for dimerisation of this domain [1].	25.10	25.10	25.10	25.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.45	0.72	-4.16	27	290	2012-10-04 14:01:12	2012-06-20 10:24:33	1	6	113	3	147	420	77	75.80	24	67.77	NEW	+Ro+h-IIh-ILcsh..pusspKT+IhYpANLsachhpcYlshLhcpGl...I....pp.ssspYplT-KGpclLcphcchhchhp	......................................pl.hhcILph..h.......p.......sstp....h...T..cl.....h..hps.s.....L.sapp....hp+Y.lphLhcpGL...l.......................pp..psp.....p....Y.p..l.TcKG.p.c.hL.c.p.h.cph.p...t.......................	0	48	87	120
+14799	PF14948	RESP18		RESP18 domain	Eberhardt R	re3	Jackhmmer:Q5W5W9	Family	This domain is found in the glucocorticoid-responsive protein regulated endocrine-specific protein 18 (RESP18) and in the N-terminal extracellular region of receptor-type tyrosine-protein phosphatases containing the protein-tyrosine phosphatase receptor IA-2 domain (Pfam:PF11548) [1,2].	25.00	25.00	25.40	27.50	21.50	24.40	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.31	0.72	-3.98	6	113	2012-06-20 10:28:28	2012-06-20 11:28:28	1	3	36	0	39	121	0	96.30	40	14.55	NEW	GQuQVGVGQhWPL.GhsTPVFQ+LQsVLQQIsPpGLFWKDDhTQcVMoQKMt+IS+LHPp-P.....CsRsspAusPT+TstshuKQEEKLpLLhP...tpSPhVKVNR-pC	.............GQsQsussQhhshhpVosPVLQ+LQs.VLpQLh...sQG...LoW+D.DlTQaVloQEME+lPR..L.+..P...-P.....ps+DtpulsPp+s....s.ttp......P.............................................................................	0	3	5	11
+14800	PF14949	ARF7EP_C		ARF7 effector protein C-terminus	Eberhardt R	re3	Jackhmmer:Q8N8R7	Family	This family represents the C-terminus of the ARF7 effector protein (ARF7EP). ARF7EP interacts with ADP-ribosylation factor-like protein 14 and unconventional myosin-Ie and through this interaction controls movement of MHC-II-containing vesicles along the actin cytoskeleton in dendritic cells [1]. It contains a conserved CXCXXXXCXXCXXXCXXCXXXXCXXXCXC motif in it's C-terminal half.	27.00	27.00	33.40	33.40	19.50	20.30	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.15	0.72	-10.99	0.72	-3.61	25	126	2012-06-20 11:48:40	2012-06-20 12:48:40	1	4	78	0	92	118	0	103.30	45	54.39	NEW	csp+pLcpLthpsssp.hl.....ssFsPpsopRcKR+h...scp.p......shsccsplYDcpGhLhpsu...t...DLCDCL-h-CsGCaaPCscCuSsKCGscCRsNRKWhY-plEh-u	....................................................................p.t+tL+sLtFpNPG.ps........-.Fs....Pcs...t.p....RcKRth..hpphs..................hpsh..tps+hYDppGhLltss......h......DLCDCL-c-ChGCFYPCPpCsSsKCGsECRCsRKWlY-pIchEu.......	0	20	26	51
+14801	PF14950	DUF4502		Domain of unknown function (DUF4502)	Eberhardt R	re3	Jackhmmer:Q14159	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.	27.00	27.00	37.90	37.30	26.10	23.90	hmmbuild  -o /dev/null HMM SEED	358	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.31	0.70	-5.29	4	71	2012-06-20 15:14:56	2012-06-20 16:14:56	1	5	36	0	34	68	0	196.00	42	38.14	NEW	KRKRshchEpPSFPsEps.phRRuGh+TstsusSLScAWLRCGEGF.coush.SL.TuEKKohTEKHLELss+PKpE.TTSK..uTStLssIsWSSStSDhSDEDKThs..........phQR.........................D-LQhIDWElDSD+t-ss-sD.EhE--c.sl-ISDCsSsA...SLTs--p.sE.PcssssEILEYSSDSEc--DsEpsLhIDSESsHKYcssFtSDuR.lh.p.hs.cscSsEsILpTPQK.Ts.....KhPKTPEsSuK+.KKLLRGGLAERLNtLQNRcRSAISLWRHQClSYQpT.uGcKSGVLTVKILELHEECuMQVAhCEQLst..hsusstuhA..sGAsLKVLFTKETAspLpG+PQDlV+IaPPWQKL	...........................................................................................................................................................................................................................................................................................................................................................................................................................hplshC.c.h..........ssts...........ts.lhVLFo+ETsthL.s.tPtDhlhIaPPWp.............	0	5	7	14
+14802	PF14951	DUF4503		Domain of unknown function (DUF4503)	Eberhardt R	re3	Jackhmmer:Q14159	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.	27.00	27.00	122.80	61.50	21.30	20.50	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.54	0.70	-12.32	0.70	-6.32	4	70	2012-06-20 15:23:30	2012-06-20 16:23:30	1	4	36	0	29	74	0	325.50	56	58.67	NEW	QDAhGMFuEVHLpushhK.......u+QLEGKSCSLsGMKVLQKsTRGRTsGLFSLIDoLWPPllPLKsPGpuQsspplcTaLPPPuFCYILoAHPslGQIDhI-tD.IsKLYQPPVsRsLR-IlQhN-hSTRCSFYApVIYQ+PQLpSLL..tQ+EIWLhVTDlTLQhp-EpssuLPKTLsVhlAPSCVLusEVlEALsstssauLLF+DAlR-pGRIVClERTVLLlQKPLLussSuspSC-LsuPVpLD-LDusT.VNSICSVQGTVVGVDESTAFSWPVCDhCGNsRLEQpPEDRGsFSCGDCSplVoSPll+RHLpVFLDCsSRPpCTV+VKL.QpSIS.LLRhAAuEDGSYEVcSVLGKEVG.LNCFVQSlTop.uSC.VsLEEIELLSAs	..............QDuhGhFuEVpLph..sh.p.......s+phEG+oCpLsGhKVLQ+sTRGRssGlFSLIDoLWPPshPLKs......PGps.Qs.s.cEh+sp...LP...PPuhCYlLoApss.upl-lh-...............t-sIspLYpPPss+sL+-ILQhssh.u.sRCSFaApVIYQR...PQLp.ull.lp.QREIWLlVTDsTLQhp-EpcspLP..KTL.VhVus.CVLssEVlEALssuus+slhFKDALR-p.GR.IlC.sERTVLLL..QKPl..LsssSu..........ApssE...LssPVh...........LDpLDSsT.VNSICSVQG..sVVGVDEsTAFSWPVCshCGNu+LEppPc..c.pGsFpCupCuplVsSPlh+hpLpVFLsC.SpPps.pVKVKLhQpo.ISSLLt.uAt.E...D...GsYEVcsVLGpcVG.L.saVpuhotp.s.h.hsLEElpL...........................................	0	4	5	13
+14803	PF14952	zf-tcix		Putative treble-clef, zinc-finger, Zn-binding	Coggill P	pcc	Jackhmmer:Q9NWW7	Domain	This domain resembles the zinc-binding domain of prokaryotic topoisomerases, family DNA_ligase_ZBD Pfam:PF03119. The function of the eukaryotic proteins it is carried on is not known.	31.20	31.20	31.90	39.20	27.60	31.00	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.18	0.72	-8.54	0.72	-4.62	12	74	2012-06-20 15:35:29	2012-06-20 16:35:29	1	2	59	0	45	72	0	43.10	65	7.99	NEW	pplu+hTlRGl+KCPcCGshN..GoRuh.CKNcsCstlhpthsstp	.SDLGKATLRGIRKCP+CGTYN..GTRG.LSCKNKsCGslFRhuucK.p...	0	8	11	26
+14804	PF14953	DUF4504		Domain of unknown function (DUF4504)	Eberhardt R	re3	Jackhmmer:Q96LT6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 253 and 329 amino acids in length. There are two conserved sequence motifs: LLGYP and SFS.	25.00	25.00	25.70	25.10	24.30	24.20	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.53	0.70	-11.71	0.70	-5.10	29	96	2012-06-21 08:33:36	2012-06-21 09:33:36	1	6	77	0	61	96	0	236.90	26	75.63	NEW	stpshhttt+p+hstssshcLss-lLAlspGL+PslLhDhs...usssspLQpaLppL.....Qssuhl......hp.........sL+lh.Ip-.sh...........hllpscthsp+lcpsLhupst.ll.VshppppPslso..p.sslts.ltsllsphp...................................................shppst.ssshssplpsopasLsTl.GhLLGYPVsYh....Fspsput-..pCLohpsL+la..........pshl..sapsspst...t.......p.pLhSFSVPpsL.sthps.h-sWtcphhs+hppp.....ssassLplpspssphsulsL	..........................................................h.......thphp...s.phpLtt-llAVspG.L+PulLhDhs...ss..hsplQphL.ppL.......pshshl...............hp.......sL+l.h.ls-.s............hllssctht.p.a.l...cpshh...up.t...hlpVs.pptpPplhs...p..ps.ltshltp.lhpthp.................................................................................t.pps..hhs..sthpssshsL..sTlhGlLLGYPVsYh...............Fp.spspc.......sCLuhssLcla..........pshh...sh..t..p......................................LhSFSlPtsl..thpp......p.W.pph.tphptp........p.hts..lphp.p.hp..s.............................................................................	1	20	33	46
+14805	PF14954	LIX1		Limb expression 1	Eberhardt R	re3	Jackhmmer:Q8IVB5	Family	This entry represents the limb expression 1 (LIX1) family [1].	27.00	27.00	31.40	31.20	25.90	18.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.57	0.70	-5.40	8	135	2012-06-21 10:00:33	2012-06-21 11:00:33	1	3	70	0	80	111	0	228.70	68	83.86	NEW	c-ulsulspshAcaspGaucVNVVEALQEFWQMKpARGAch+sGALVlYESlPSsuPPYVCYVTLPGGSCFGSFQsCPTKAEARRSAAKIALMNSVFNEHPSRRITD-FIEKAVsEApASF..............pG.sss-s-sPsTGIGAFRFMLEuNKG+TMLEFQELMTVFQLLHWNGSLKAMRERpCSRQEVlAHYSpRuLDD-MRSQMALDWlsREpE...o.PGlLSpELAhAE+ELEpARLAGRELRFPKEKKDIL.LAtuQl	....................p.........s.tp.s.sh.t..c.....lNVVphLQEFW.phKQsR.....G.......As..............h...pstuLVVYE.lPSsuPPYVCYVTLPGGSCFGsFQhCsTKAEARRsAAKlALMNSVFNEhPSRRITcEFIp+SVpEAlASh.....................sG..sh--ADsP.sTuIGAa+aMLESNpGKoMLEFQELMTVFQLLHWNGSLKAhRERpCSRQEVluaYSpRuLD-cMRspMALDWltREpp...s...PGhlupELt.spREL-cARhAGpELRFaKEKK-IL.LAhsQl.....................	0	15	21	43
+14806	PF14955	MRP-S24		Mitochondrial ribosome subunit S24	Eberhardt R	re3	Jackhmmer:Q96EL2	Family	This family of proteins corresponds to mitochondrial ribosomal subunit S24 in eukaryotes [1-2].	25.00	25.00	27.80	27.00	22.60	21.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.58	0.71	-4.33	19	118	2012-06-21 10:09:16	2012-06-21 11:09:16	1	4	92	0	73	109	0	125.70	48	78.56	NEW	tKspuGRa+lo.+ts+PLTYEMAp.PHhIuHRKoWNSWpTuNLcsttp.suEs.........slEDhFIR+FlpGTaHshls...SEllIKRppNhIhIAull..hpplsspKhYFLlGYTEElLShaL+CPVKLElQoVssKpsVlaKYI	......................s.+spuuRh+ls.+ts+PlTYE.ApsPHaIuHRKuW.ShpTuNLcGp.......t+.su-p.........slEDhFlR+FhhGT.a.uhls...sEllIKRptNhlcIsull...hpplss+KhYFLlGYoEpLLSaahKCPV+LELQTVssK..VlaKYl................	0	29	35	54
+14807	PF14956	DUF4505		Domain of unknown function (DUF4505)	Eberhardt R	re3	Jackhmmer:Q6P1X6	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 166 and 225 amino acids in length.	27.00	27.00	43.60	33.10	19.30	22.10	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.32	0.71	-4.65	12	106	2012-06-21 10:49:48	2012-06-21 11:49:48	1	2	92	\N	71	107	2	161.30	42	81.20	NEW	slpYsQGQSPpP+lREYFYYIDHpGMLFLDDu+hKNFTSCFKEK+FLcFFFpRLRhNc.....ouRYcp-FPalS.CGRERNalRCDDhPlVFTHllpcsssppp.....LsYsHuG-hLoV.F-Pp+lhMhPtoGRVYHPAPE+sGGlGLlRSpLAIELSppFsFssG-s..pP.PTHFpWsGppaELspcWhcs	...........................t............t.phREYFYalDHpG....LF........LDDu+hKNFhoCFK-h.pFL.FFFpRLR.Np............................osRY.pt.......pFPalS.CG+ERNFlR.....C-D..pPlVFT.cl..lttspt.t.t..................Lsastu.uptLslP.FpPppLhh.spsGRlYH....PA.....P....p.....p......s......G.....u...l.....GLV+StLAhE.LStpFpats.....st........t...Psph.WpspphtLp......s...........................................................	0	30	37	54
+14808	PF14957	BORG_CEP		Cdc42 effector	Eberhardt R	re3	Jackhmmer:O14613	Family	The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton [1]. They may function as negative regulators of Rho GTPase signaling [2].	25.00	25.00	25.20	25.20	24.90	24.70	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.70	0.71	-3.20	13	233	2012-06-21 12:15:36	2012-06-21 13:15:36	1	5	43	0	137	195	0	116.20	30	44.46	NEW	hlKNAlSLPhLsspputphsstph................sKS.SSSPsKpsp.ttt...........p.hNuuuutus...hc.phsEppFGpLTDhs.............................sstspssuhc+A-SlhSFHlDLGPShLuDVLulMDKpth-pc	.................................................................................................................................................................hlKNAhSLP..lst...th..hs..p................................................t...sPs+.sp..ht..t............................hp.s.ut.st..........p.s...stpt...sphps.............................................................................................................................................s.spps..hh.cpu-SlLS...h+..l....DLGPSlLs-VLslMDpt...............................................................	0	7	23	57
+14809	PF14958	DUF4506		Domain of unknown function (DUF4506)	Eberhardt R	re3	Jackhmmer:Q9H8K7	Family	This domain family is found in eukaryotes, and is approximately 140 amino acids in length.	27.00	27.00	27.60	27.50	26.40	24.20	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.71	0.71	-4.60	14	90	2012-06-21 12:23:39	2012-06-21 13:23:39	1	1	68	0	65	83	0	134.90	33	35.56	NEW	p-tslLhs..ss-sp.sPC.LplphsPc...cIuulsllsSA.slEla.lG..pEYptTshGcslp...pppsc.tlphYRhclcl-.SshsshplKLLo....upchCVasu+lhls.pssslsop.....hsptIDlp+VQplLpphGo	..............p.sllhp...pspsp.pP..ChLhlpssPp...pcIsulsllSsARshEVY..l...G......p....EYCGTsR.Gc...sVs......................tssppcplhlY+p.LcL-...os..spuCclK..LLSh........uc+.psValu+lhVphpssssss..s.t..slsstlDLp+VQshhpshGo................................	0	14	21	35
+14810	PF14959	GSAP-16		gamma-Secretase-activating protein C-term	Coggill P	pcc	Jackhmmer:A4D1B5	Family	GSAP, or gamma-secretase-activating protein, also known as PION, regulates gamma-secretase activity. The holo-protein is a large, approx 850 residue protein that is rapidly cleaved to an active 16 kDa C-terminal fragment that is the stable, predominant form. GSAP is expressed in inclusion bodies and is important in brain function. It dramatically and selectively increases neurotoxic beta-Amyloid production in the brain through a mechanism involving its interactions with both gamma-secretase and its substrate, the amyloid precursor protein C-terminal fragment (APP-CTF). Accumulation of neurotoxic beta-Amyloid is a major hallmark of Alzheimer's disease.  Formation of beta-Amyloid is catalysed by gamma-secretase, a protease with numerous substrates that catalyses the intra-membrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) [1].  The secondary structure of GSAP is largely alpha-helical, lacking well-defined tertiary structure. GSAP represents a type of gamma-secretase regulator that directs enzyme specificity by interacting with a specific substrate [2].	27.00	27.00	30.40	42.60	26.40	20.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.29	0.71	-4.34	14	77	2012-06-21 13:25:58	2012-06-21 14:25:58	1	3	66	0	53	85	0	111.40	39	13.83	NEW	L-hsptLhpLlp+hhthshp.....hpph+shsh.lsphssspc...htlFplhpRhhpAspsLshPhP.GFpohashLGhRsLshcsFLQYl-psVhpLotsslptlhpDl.-so.ccs..pphKa	........................L-h.ptLhpLls+hhthsh+.......hcph+uh.L.....hsphuust.c...aslFclhpRhhpAs.polshPLPsGFpohaThLGh+CLshcshLpYl-suVh.Lopsslpplhp.Dl.-so.pp.s...chKh.........	0	17	22	37
+14811	PF14960	ATP_synth_reg		ATP synthase regulation	Eberhardt R	re3	Jackhmmer:Q96IX5	Family	Members of this family are subunits of mitochondrial ATP synthase (F-ATPase) [1-2] and vacuolar ATPase (V-ATPase) [3]. In F-ATPase, this subunit regulates mitochondrial ATP synthase population [4].	25.00	25.00	25.90	25.20	24.30	18.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.45	0.72	-4.77	11	92	2012-06-21 13:36:47	2012-06-21 14:36:47	1	3	58	0	53	100	0	46.90	48	42.08	NEW	MAu....tt.thpGhp+hFNupThsGRANsAKATYAuluLlhlaa+h+.pK	...........MAG.....tt.phpGhpKaFNShThsGRtNsshATYAuluLlllaa.+l+.+K.....	0	15	18	32
+14812	PF14961	BROMI		Broad-minded protein	Eberhardt R	re3	Jackhmmer:Q96NH3	Family	Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth [1].	25.00	25.00	25.30	25.00	16.30	22.50	hmmbuild  -o /dev/null HMM SEED	1296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.44	0.70	-14.11	0.70	-7.43	2	151	2012-06-21 13:57:55	2012-06-21 14:57:55	1	4	62	0	96	138	1	532.70	29	89.28	NEW	LQshLRpLhpSVK-+IoGAPSlECAEEILLHLEETDcNFHNYEFVKYLRpalpsoLGuhIE.EhEpaTpspsps.tSG.DTlVptVTKpTpESppYKpMMpoLKphMMhVVEShINKFEEDpMpppEhp+KIQ+ppS.S.hsDNCSDSDSSFNQSYtFh.ptpLQlIh-pLDPGpP+EVRaEALQoLCpAPPSDVLsCEsWTsLpcpLosuLoDPDP.hSD+lLpFaApTFo.SPLphTK-IYsSl..sKhLchaFL.+c.phPohoTuIDhspPshhpLLKphRLhN-aQKEssoFWIRHPEKYMEEIlENTLSLLul+p-Q..Sp.sSpK.L-PIahhuLlDhKAsWFKKWMHuYYSRTsVLRLLE+KYKSLlssAlQQCl.Yh-.C-Ahp.-EhLth.+phtppp....tphhYoupELpalYFlHSLClLGRLlhYTpGR+hFPIKlKpR+D.VoLTDLlVlhhplhY.pPp.PphspsAhhDshSPsshVhEVLRhLCDppECAVECLYp.sVIEsLLtPlhsLhpGphst.ss.EoALhHhADhLARIAos-cGLoLLLYscNhsSuEtcS.ouAHlIsQFopKLLsc-lpl.suSpM....pGAFI.VCRQhYsTCEGLQVLhPYSLHEsIApAW+pTS.hSERlPTPV.sussh.u.SQE.QsshAWEE.LLDsLLNFAATPKGLLhLQpTGAINECVTaMFsRasKKLQlSRpcKFGYGVhVTQVAoTAsGhlALQSSGFlpTllsELWusLECGR-DVRlsHP+STPhDPIDRSC.KSFLuLVNLLs.P.AVaELlGppsLPNKpEYsLREhsTsVlDlhDRLIIlNS-AKI+SLFNYEQSHhFGLRLLSVlCCsLsohLLLEuQYplo-lLLpuQc-NlhEsspuct-FIIDGLSVERNHlLVRIshlGGP.ERhLPPRsLpKGsDPYPWPMhSoYPLPphYl.-VsK.hchKQ-s-lGthLhp.K.o-+pspWh-sCRRQFCKhMtsKsshloG.sLh-LLEhhVLHLSpSss-CaFPssE.pssDssVKscSLSSVpQLGlcholRYGKFLpLL+-suEpDLsLlLKHCpcFLpQQps.lpSpL............ssYsGHDWFsSolFhlMhGDht+oLphL.+FSRLLsSAFLW.PRLH.ShaLsh-hhpSuIHPlY.CosHYlEMLLKsEVPLVFSAF+MSGFsPSQIClQWluQCFWNYLDW.EICpYlsTCVhhGPDYQVYhCluhhRHLQQDILQHTQTQDLQVFLKEEslpGFRVSsYhEYMEhLEpsYRshVLpDMRsIhspSo	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	33	35	68
+14813	PF14962	AIF-MLS		Mitochondria Localisation Sequence	Coggill P, Hetherington K	kh6	Jackhmmer:Q8TDB4	Family	This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with Pfam:PF07992. This protein family is an N-terminal domain for the mitochondrial localisation sequence for an apoptosis-inducing factor [1]. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.	27.00	27.00	32.20	28.80	25.10	24.20	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.24	0.71	-4.63	7	112	2012-06-21 14:32:17	2012-06-21 15:32:17	1	4	39	1	56	87	0	138.80	31	31.37	NEW	MahpRAV.+pLA..hRAssssAPLt...KDA.........olRthSSsthPGsSGoNMlYallVGsoloAGGhYsYKTVoucps+asE+hsplcp+TKuElpP..hpucpEslupsEcAssE.......As..olsEus.....sl-sEEsPsA.shssscEus.ssssps..EAs.sEssslsuEstPcVsD...AAs..Eos..ssEss.EVp	..............................uh.ppLs..hRsss.....sht...+st...................hRphuSsussGu.sG.sNhlYhLlVGlossG.uGhYAYKTlppDppRYsERlssl....pp+s+.tp.h..p.......................................................................................................................................................................t.............................	0	2	7	21
+14814	PF14963	CAML		Calcium signal-modulating cyclophilin ligand	Eberhardt R	re3	Jackhmmer:P49069	Family	Calcium signal-modulating cyclophilin ligand was originally identified in a screen for cyclophilin B-interacting proteins. It is likely to be involved in calcium signalling [1]. It has also been shown to interact with many other signalling molecules including proto-oncogene tyrosine-protein kinase LCK, tumor necrosis factor receptor superfamily member 13B and EGFR [2-4].	25.00	25.00	25.60	25.50	24.40	24.80	hmmbuild  -o /dev/null HMM SEED	263	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.56	0.70	-11.69	0.70	-5.03	5	67	2012-06-21 15:17:21	2012-06-21 16:17:21	1	5	46	0	39	60	0	205.50	50	78.87	NEW	SASQRRAElRRRKLLMNSEERlNRIMGhH+PssGsp-Espp-oc..h-.DKosPLoLsSlSKRo.llpGDuVp..ouss-.psuSuu-t+ssplG-KLD.a.Kssphpu-DsutlRcRNRGDlsS-ussRss+cGL-pYLSRFDEAMKLRsQLssEKPSQDcGsssEE....FDSFRIFRLVGsALLAlsVR.hFVCKYLSIFA......PFLTLQLAYMGLSKYFPKGEKKVKTT..VLTAALLLSGIPAEVINRSMDTYSKMGDVFTDLCVYFFTFIFCHElLLaaG	..........................................oAuQRRAElRRRKLL.NSEpRhNRIhGap+s.ssssp-.Es.phpth......-.-+.pshsh.sSsSKR...sshGssss........suss-.p.ss...hhs.t.h.tp.p..........cs.htlR.RpRst..ssp..shtpss+.GLppYLSRF--AMKLRtQLhsEKPsQ-sGsssEE....hDsFRlFRLVGssLLAlhVR.hFVCKYL...S.IFA......PFLTLp..LAaMGL.KYFPKsEKKhpTT.........VLTAALLLSG.IPA..EVIsRSMDTYp...+Mu-.VFsDL.CVYFFTFIhsHElh.hhG...........................................................................	0	6	10	23
+14815	PF14964	DUF4507		Domain of unknown function (DUF4507)	Eberhardt R	re3	Jackhmmer:Q96N11	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 346 and 434 amino acids in length.	27.00	27.00	28.30	28.20	25.10	23.10	hmmbuild  -o /dev/null HMM SEED	362	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.19	0.70	-5.71	18	101	2012-06-21 15:24:45	2012-06-21 16:24:45	1	3	82	0	69	102	0	311.90	35	86.20	NEW	M..scl+psL++hcFPpsApEALt+l-.......pLhssR..s.pttchsh-llsEFlFtEhc.ccspttp.................phsslQELQLlplLs-a...Fsps.us-AsRsslFhuLFuspts.t...........................RhplLu+LVShAVussssslLsuAGhWMQQ..lGssSs.SlcLApsllsDYhsLs......ssos-pLKpLshluP+FsusFlTAVs-LY.s.....tpsp.tsPPssLL-lIs-Wlo-NPp.LClss.p...thsLPs.........Gulshs.hTPlsGLlRW.CVLAPLspspppp..........................lYSKLHLulLpuL....................phssssspttslsupcLspllcsLpphhpp......sssssspthplul-RhAQAlQVAhuosClhsNpppLhshLppLPtp	......................................h......p.shh..ph.tsAhEsLhpl-...........p..hpp.......hpphshpllpEFlF...p...ccss..p.................phsslQELQLlclhssY...Fpcp..scDusRphlF.uLFuspts.t..........................p....RhplLu+LVShAV...............u.ssphPlLpsAusWhQp...........s..ss...hslcLApslVcDYssls............................ssohppL+pl.psuP+FsspFlTuVssLY.............sst..h.PP.sLL-hIspWlhEsPp.lhhs.hp....shsL....Ph...........Ghlth....TPLsGLlRW.sVhAPLs.ppp.......................................hYSpLHLulLpsL...............................hp.ps.hsphthl.hpchsslV.cplpphssp.......hss.psspthphul-RlAQAlQlAhuosslhsspppLhslhppLP...........................................................................................................	0	23	29	50
+14816	PF14965	BRI3BP		Negative regulator of p53/TP53	Coggill P, Hetherington K	kh6	Jackhmmer:Q8WY22	Family	This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours [1].	27.00	27.00	66.20	65.00	25.20	21.30	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.07	0.71	-4.90	26	99	2012-06-21 16:19:23	2012-06-21 17:19:23	1	2	38	0	51	85	0	172.40	45	78.46	NEW	hpphupohppTLsshlGtEsh+slpchhSplh.thspulsVhh.sL.tIhspLLssLGLDuspLTQ..hhSPupVpo....hLLhsuusLlAYWhLSLLLGhshuLL....GRhhWhl+lsLFhhuhVhll+ph.sssp+AlL.Lshlsshhhhot.sGshhpt..........spLEtKlcpL-pQlc.LphRhpR	........................pphupuhhtolsshhG.-sh+hltchhoplh.thspulsshhtsLhtlhscLLcsLGLDu..spLoQ.....hhSPupVpo.....hLLhsuusLlAYWhLSLhLGhshulL....GRhhWll+llLFhhuhVhllpp.h.s.sp+AlL.Lshllhhhhhot.sG.hhpt................spLEtKlctLEpQlc.LphR.pR....................	0	2	5	18
+14817	PF14966	DNA_repr_REX1B		DNA repair REX1-B	Eberhardt R	re3	Jackhmmer:Q96EN9	Family	This family of proteins includes Chlamydomonas reinhardtii REX1-B (Required for Excision 1-B) which is involved in a light-independent DNA repair pathway [1].	24.00	24.00	24.00	24.10	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.13	0.72	-3.61	20	102	2012-06-22 07:42:38	2012-06-22 08:42:38	1	2	75	0	64	107	0	91.40	35	42.95	NEW	stsLL+pFhplQpcRApsYscaccGFpsalpsusp...ssYppLCsclTp-FsshScp........llplEstLp..chsRs-lApllcslQppEKpKLpLTAplQlLK	...............h..tLlpphhtlQpcRsphapphccGappYlpousp...stYpphspc.lTptFsssS+p..........................VltlEutLtt..hspssLAphl+slQptE+p+LphsAhlQlh...................	0	26	39	49
+14818	PF14967	FAM70		FAM70 protein	Eberhardt R	re3	Jackhmmer:Q8WV15	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 241 and 349 amino acids in length. The function of this family is unknown.	27.00	27.00	33.10	27.60	21.00	21.00	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-12.22	0.70	-5.23	7	144	2012-06-22 08:12:48	2012-06-22 09:12:48	1	3	39	0	58	143	0	275.00	57	97.69	NEW	h.s...s.sssl.h.sshuuFs+RK+sSlahssoLLlVSlhILTlGLAATTRTENVTVGGYYPGlILGFGSFLGIIGhNLlEN+RQMLVAuIVFISFGVVAAFCCAIVDGVFAARHI-.RPLhuGRCpaaSSssuahhD...h......................EVTCpo.s.stCpLKV+SNTCYCCDLYNCtsp.E.ssuYYEalsVpuCQDVlHLY+LLWuuslLNllGLFLGIITAAVLGuFKDM..sshup.shu.ss.Ppl.YssstQlhuYsuFh.ossslPshouY..sLQ.suhFPu.........ossSsLu...DsQssusS....hhsspsPPpYuPsYa.PsEKPPPYoP	...................................htsFsRRK+sSlahssoLLlVSlLILTlGLAATTRTpNVTVGGYYP.GlILGFGSFLGIIG.sLlEN+RQML....VAuIVFISFGVlAAFCCAIVDGVFAARHI-h+PLhs.s...RCpah.spssth..h-.h.t.........................pV.sC.phs.s.Cp.+l+uNTCaCCDLYsCGsp.EhssuY.....YEalsVpSCQDl.lHLY+LLWuuTlLNllGLFLGIlTAAVLGuFKDM........s....u..........s.s....ss.Ppl.Y.st..Q..lhuYssah.osspLPsh.SuY..shQ............s.usFPu....ossos...lS....-sQ.sso.ssS.ahh..sssAPPpYuPsYa.PhEKPPPYsP.......................................................................................	0	3	7	22
+14819	PF14968	CCDC84		Coiled coil protein 84	Eberhardt R	re3	Jackhmmer:Q86UT8	Family	The function of this coiled-coil domain-containing family is not known. It is found in eukaryotes.	25.00	25.00	25.50	25.50	24.50	24.60	hmmbuild  -o /dev/null HMM SEED	336	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.54	0.70	-4.93	13	109	2012-06-22 08:26:03	2012-06-22 09:26:03	1	3	64	0	60	112	0	256.10	32	89.59	NEW	aCplCRpNHsp.G++H+Y.ssH+puLsshLs+FpsKls-lRthL+sPsl.c.t..pscs+hWChFCct-lt-psS....ohssusAlpHLASs-HlKsl++Fhh+aGushcph-pFpIocs-hu+acppsppshsphpsps-shhsptsssl+cl.cs.........p.pp.phh.pshpss..p..ppP..sst...pssshshhhhssp.t..httotts.....................................................ssshshs.ss...shshtts..G..sL....sslus..shsut.GNVHoGAsPPWLpss-cs.....tssp..phsPSspuhhpppcptKh+KLNPcR..V...GAsascc...p+................ssssWLPsFGRVWQSGsRpcSR+EFc+E+pphcc	..............................................C.lC+.sa.p.GctHhY..pHpppLpthLp+hh.plpssRhhl+ssps.p..............tpcpphW.ChhCst-lpcp.S.....ohhhushlpHLA..Ss-Hh+sspcFhhcptuphp.h-..pFhlo..p-ht+acpph...phhpph..tppp-t.h.tt.hs...pphcp.........p.p.p.h.psh.ps.......s.......p...........................................................................................................................................................................t..s.........h...h....s.lu....t.ssh.GNlHoGA.PPWh.tp-t..........t.........p..s...t.hhppp....p.ptK.+KL.sspR..V...GAsascp...pp................ssssWLPsFGRVWpsGpRhpSR+pFctctt....p....................................................	0	14	28	41
+14820	PF14969	DUF4508		Domain of unknown function (DUF4508)	Eberhardt R	re3	Jackhmmer:Q9NWQ9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 253 amino acids in length.	27.00	27.00	28.30	27.80	25.70	24.00	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.49	0.72	-3.99	12	83	2012-06-22 08:49:40	2012-06-22 09:49:40	1	4	70	0	53	78	0	98.90	44	54.48	NEW	stpEhRhllpWFtpWSthQRpcFLpsLlpK........Asss.p......lsuLlsuLpsLsl..pD+PPSlFpCpl+LaspWFpsWs-p-+sphLppLcchDscFst+ahpclu	....spEh+ClLpWFssWSssQR-cFLpDLVuK........................AVPG.K..............lpsLLcuLppLuV...sD+PPsIF-CQL+LacQWFpsWuEpERNcFlcpLEtt-scFssKaaptlu..............	0	11	15	33
+14821	PF14970	DUF4509		Domain of unknown function (DUF4509)	Eberhardt R	re3	Jackhmmer:Q86SX3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 212 and 449 amino acids in length. There is a conserved WLL sequence motif.	27.00	27.00	27.90	27.50	25.90	24.40	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.33	0.71	-4.63	8	80	2012-06-22 09:10:21	2012-06-22 10:10:21	1	4	45	0	38	72	0	151.30	42	43.60	NEW	DR..PEAshsLWplLa................phL.psLs-hph........hsssts-sp.hpl...VKpALtspGY.PphphhQLPpDsupGSRELLLALuWLLA+ssllEph..Ltpp+Vphucthslsp..........................sEs.sS.u.P.ustht..scts...s-l+clpWLhG+LRapaRsLhopppEQstLlsKIHhhTp.ss+Sc....QsLuH..LSVsEschL+DPEshpp	...................................................hWplLh................t.L...l...t.........htp.h.psp..hph....VK.sLt..GY.PphthhpLPpDus....pGSRELLLALuWLLucssl.-ph....LtptpV...l.ucph.s.lsp................................s-shsS.s.s.....ustht....scss......sDlRtlpWLhG+LRapWRpLhspQQEpCtLLsKI.H.hTt.usp.p....psLsH..LSVsEschl+cP-shpp......................................	0	11	15	24
+14822	PF14971	DUF4510		Domain of unknown function (DUF4510)	Eberhardt R	re3	Jackhmmer:Q86SX3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 242 and 452 amino acids in length. There are two conserved sequence motifs: LEA and WMD.	27.00	27.00	91.90	91.90	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-11.07	0.71	-4.07	4	44	2012-06-22 09:22:30	2012-06-22 10:22:30	1	3	20	0	11	48	0	161.10	69	41.03	NEW	TCusEsPsssuQPsFLPhlsE.sGuscL-hVsppLQALpEELppssEsRRAAWEA+lGGsupGsEWSAuR+AspEAVppE..L.uALp........tsWEcuusPu....QPp.sP+RLV+u-sGAuss.tsLpAApVItsLRu+EACLctsL+pLQpQCRQELARLAuAhPGLIWI.PPt	.....................TCuPEsPAAASQPTFLPhlPE.pGsGELELVsRELQALpEELp.......EAsEpRRAAWEAKAGGCGpGPEWSAu.RRASREAVE+E..L.uALQ........psWEpDuGPA....QPH.GPHRLVRREDGAAGs.psLRA.AEVIRTLRSQEACLEAVL+pLQGQCRQELARLsGALPGLIWIPPPG.	0	1	2	2
+14823	PF14972	Mito_morph_reg		Mitochondrial morphogenesis regulator	Eberhardt R	re3	Jackhmmer:P17152	Family	This family of proteins regulate mitochondrial morphogenesis via a mechanism which is independent of mitofusins and dynamin-related protein 1 [1].	27.00	27.00	52.90	31.30	22.60	22.90	hmmbuild  -o /dev/null HMM SEED	165	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.23	0.71	-10.88	0.71	-4.84	10	101	2012-06-22 10:12:39	2012-06-22 11:12:39	1	3	80	0	70	99	0	156.30	54	87.21	NEW	Sso....stlIREVYDuENAHEpFEhEL-+ALEAcsshIVIEPo+LGDETuRWIsVGNCLHKTAVlSGlAuLhouLlWh.-Rh...llusPhuulSlhCsuLYslSWpaDPCCcYQV.EpDspcLs+LP.Ls..ssSSPVVLVR+DsppRKhLHpsloluuAuaCAW+lYcsa.K	.................h.sssaIl+ElYsuENAp-pFEhELEpALEAphcaIVIEPoRlGDETARWIsVGNCLHKTAVLuGsusLho...sL.................hh......s....chp........aIulPuGsLSlsCssLYulSWQFDPCCKYQV..Eh.Dsh+Lu+LP.LpsLos.SoPVVLVR+DDh+RKhLHsoIALuAhsaCsh+lYchY.t.....................	0	23	28	50
+14824	PF14973	TINF2_N		TERF1-interacting nuclear factor 2 N-terminus	Eberhardt R	re3	Jackhmmer:Q9BSI4	Family	This is the N-terminus of TERF1-interacting nuclear factor 2. It is required for the formation of the shelterin complex. The shelterin complex is involved in the protection and maintenance of telomeres [1-3].	27.00	27.00	27.50	28.70	26.50	24.70	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.74	0.71	-4.06	12	102	2012-06-22 11:39:58	2012-06-22 12:39:58	1	18	37	0	46	84	0	124.00	38	29.97	NEW	WQVlppRslcHaG+ltEFVshlspsVP-Llsh+p+tpLhhGLRA+hlLEhhcppcshs..hptlp.Hlsph....ps.psptpDhch..............cpscssFhcLVpsLlcDspt+cpahpphh.tEYGssasssLcpLhhEFLp+L-plL...PlPshpp	..................WpVlctRpVcHas+l.EFlp.lptssP..sLlpa+c+t+LhhGL+A+lllEhhhttps..hs..Lpslp.Hhsc...........tsptptpDhch...............cuppsFhp.VcpL....csP.chtphhQ...h.t-YGpsF.s.uhcpLhhEaLspLEphLPssphpp..............	0	3	7	24
+14825	PF14974	DUF4511		Domain of unknown function (DUF4511)	Eberhardt R	re3	Jackhmmer:Q99622	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 116 and 127 amino acids in length.	27.00	27.00	28.90	30.40	26.50	19.00	hmmbuild  -o /dev/null HMM SEED	105	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.33	0.72	-4.29	16	82	2012-06-22 12:03:31	2012-06-22 13:03:31	1	5	71	0	61	72	0	99.00	47	71.78	NEW	shosEpAKslLs-lLpulspP-Nut+lp-A+csuG...N-MlKhMQhVaPlssQIQh-VIKsYGFs..sstEGllpFspll+phE+-DsElApLpsplRohaLPP.....lslss	.......hosEpAKslLs-lIpAhssPENuh+hsEA+-sAs...N-MhKMhQaVhPlssQIQ.EVIKsYGFs..sstE.GllpFupLl+phEppDsEIApLpupl+ulaLPPhsls.s..................	0	18	24	42
+14826	PF14975	DUF4512		Domain of unknown function (DUF4512)	Eberhardt R	re3	Jackhmmer:Q8TCD1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 74 and 104 amino acids in length. There are two completely conserved residues (C and P) that may be functionally important.	27.00	27.00	29.90	32.10	22.10	21.10	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.66	0.72	-3.16	36	88	2012-06-22 12:35:03	2012-06-22 13:35:03	1	2	72	0	54	79	0	80.60	34	93.55	NEW	VClPChlIPlLLala++FlpPllh+hhsP.....W..KcA.tp....ts..ph.hpscsssCsh..........................................pspspst............tt.st.tssssspsKK	..VCIPCIVIPlLLWlY+KFlpPhlY.hluP....hWs.Kss.pp..psts..ph.hpspssss...............................................................................tt...............................	0	13	17	37
+14827	PF14976	FAM72		FAM72 protein	Eberhardt R	re3	Jackhmmer:Q86X60	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 264 amino acids in length. The function of this family is unknown.	27.00	27.00	34.70	29.40	25.70	23.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-10.92	0.71	-4.37	7	81	2012-06-22 13:09:17	2012-06-22 14:09:17	1	2	54	0	52	72	0	127.70	55	75.13	NEW	MSss.thsFpD+sVohLsC+FCcpVLspRGMKAlLLADT-h-LaSTDIPPspslDFlGpCY.Tp.CKCKLKDIACLKCGNlVGYHVlsPCpsCLhSCNNGHFWMFaSpuVhshsRlDsoGsNhLLWGsL.P-h-Ess-Eph.....phstEEhlR	.....................Ftp+pV.hLsCpaCcplLssRGMKAVLLAD.Tcl-LaSTD........IPPsss....VDFh......G.........p........CY.h...........T..............chCKCKL+DIACLKCGNlVGYHVllPCssCLLS......C...N....NGHFWMFHSpAVhslNRLDu.oGh..shLLWGsL.P-h--sps-p......p.stEphlR..........................	0	26	28	34
+14828	PF14977	FAM194		FAM194 protein	Eberhardt R	re3	Jackhmmer:Q7L0X2	Family	This family is found in eukaryotes, and is approximately 210 amino acids in length. There is a conserved YPSG sequence motif. The function of this family is unknown.	27.00	27.00	29.80	31.30	26.80	25.10	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.26	0.70	-11.27	0.70	-5.34	13	112	2012-06-22 13:34:15	2012-06-22 14:34:15	1	4	50	0	70	110	0	189.40	30	29.71	NEW	ssppshhtchYcpGshF.hhhhPDGoupl..aYPSGNlAllhlss.ctsp..hhsllhEDsspss.....lLALFssoG+ussYasNGs...lhLsls.tGGhhsDppGs+h+pWsW.........sspscss....shpslplplNchlslRlhsQDKlslsFtshspps........plslGo+hhhlpP..ctlst.+p......p..c-hhhsspttK...hp+Lls+hcsplshssophh-plt.PutL	..........................s..ptp...phhpps.ha.hh.F.DGos.l....aYPSGNlAlhhlss...phst..hhshlhpDtspss........lLAlhsspGpussYassss...hhlhls.tGGphtDp.pGphl+tWsW.........sspsp.s....shpsl.hplNc.ltl+lhsQDpI.loFh.uhs.pps........plslusp....pP..cthsh.+h..........hst..c...h.sph.K....hpphhtclpthhphsss..hpphh.ss......................................................................................	0	22	27	36
+14829	PF14978	MRP-63		Mitochondrial ribosome protein 63	Eberhardt R	re3	Jackhmmer:Q9BQC6	Family	This family of proteins is present in the intact 55S subunit of the mitochondrial ribosome. It is not known if it belongs to the 28S or to the 39S subunit [1].	27.00	27.00	27.80	27.70	26.90	25.80	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.11	0.72	-3.55	11	74	2012-06-22 14:28:01	2012-06-22 15:28:01	1	2	68	0	49	75	0	88.20	41	79.01	NEW	PG..+QWIGK+RRsRsVohptKcshl+RhEhEtcspaaLs+PYLThEQEtGHApph+t...thhcthctppppKastH+hltDpL.sHLNlscpW	.........PG+.ahGK+Rhs+.Vohptppshh+cLEhEtcNpaaLs+PYhTtEQEtGHAtch..+p....................ts.hcthcttphpKa.sHhhlt-pL.sHLplscpW..............................	0	14	17	33
+14830	PF14979	TMEM52		Transmembrane 52	Eberhardt R	re3	Jackhmmer:Q4KMG9	Family	This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 160 and 236 amino acids in length. There is a conserved LLCG sequence motif. The function of this family is unknown.	25.00	25.00	25.00	29.40	24.80	24.20	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.10	0.71	-4.32	5	88	2012-06-22 15:00:50	2012-06-22 16:00:50	1	1	32	0	42	84	0	134.20	47	70.79	NEW	--sCcsoDpCs.sAcWlsLWYVWLILVslsLLLLCGlTAuCVRFCCL+Kps.sQsapsuAhQPCEVTVIAhDsDSTlHSTVTSYSSVQYPhuhRlhhsFu-hDssuMsPPsYSLYAsEsPPuYEEAlKMhKoRpEVAtsSQKsscLsuloEpEs	.....................................t.C...sp...C...t.s.cWspL.WYlWLlllhshLLLLCGlTusChRhCCLp+p...Qstps.u..Ph-lTVIuhDpDS.olpSTlTShpSV.hPhuhR.l.hshtphss...u..hP.......u.-h.PuYEEAl+M..sR.psshsupKss.L.ssst.c..................................................................	0	2	3	11
+14831	PF14980	TIP39		TIP39 peptide	Bateman A	agb	Jackhmmer:Q96A98	Family	\N	27.00	27.00	34.30	37.00	21.80	19.60	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.10	0.72	-8.50	0.72	-4.33	3	29	2012-06-22 15:25:55	2012-06-22 16:25:55	1	2	23	0	16	22	0	49.80	68	39.08	NEW	u-WuSPuuspsKRNLVVADDAAFREKSKLLTAMERQKWLNSYMQKLLVVNS	........tsWus.usshsRRSLALADDAAFRERARLLAALERR+WLNSYMpKLLVLDu.	0	1	2	5
+14832	PF14981	FAM165		FAM165 family	Bateman A	agb	Jackhmmer:Q5T5W8	Family	This family of proteins known as FAM165 are found in eukaryotes. Members of this family are as yet uncharacterised. Proteins in this family are typically short membrane proteins between 55 and 70 amino acids in length.	25.00	25.00	58.00	57.60	24.50	23.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.57	0.72	-4.46	4	34	2012-06-22 15:39:24	2012-06-22 16:39:24	1	1	30	0	19	29	0	50.50	72	86.55	NEW	pAL-NVPLLhYILAhKTLlLCLAFAGVKIYQuKK.EtKLK+pctEK.+R.AE	..KVLEHVPLLLYILAAKTLILCLAFAGVKlYQRKRLEAK....p+l.EAE+.++puE..........	0	2	2	6
+14833	PF14982	UPF0731		UPF0731 family	Bateman A	agb	Jackhmmer:Q4G0N7	Family	The UPF0731 family of uncharacterised proteins is found in mammals.	27.00	27.00	35.90	35.90	22.80	21.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-9.68	0.72	-4.07	2	39	2012-06-22 15:48:12	2012-06-22 16:48:12	1	1	24	0	23	39	0	75.90	66	83.69	NEW	shp.ssQsRRFPlEuGDS.....PGLuSuspsp......up-.sPsR.LRRCPGsHCLTlhcVPIsVYhAMttsP.....ch+sp	.PFcFGTQPRRFPVEGGDSSlt.EPGLSSSAuss......uKEhSPsRQLRRCPGSHCLTITDVPIsVYATMRKPPApSSKEM+P.........	0	2	2	3
+14834	PF14983	DUF4513		Domain of unknown function (DUF4513)	Bateman A	agb	Jackhmmer:Q6ZNM6	Family	This family of uncharacterised proteins is found in chordates.	27.00	27.00	53.30	31.80	25.30	25.70	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.73	0.71	-4.33	3	32	2012-06-22 15:50:45	2012-06-22 16:50:45	1	2	28	0	22	28	0	117.90	62	82.57	NEW	SGKDTsPlLPKLNNNsS-ENoYKPu+......Ks--IHLPRFSLKQGMIPRRYVMPWKENMKFRsVNLK+AEACGIHAGPLEDSLFLNHSERLCHGEDRKVVLKKGPPEIKIADMPLHSPLSRYQSTVISHGFRRRLV	........................shP.hPKls.sststEs..+..p......+hp-lHLPRFSLKQGMIP+RYVMPWKENMcFRNVNLKpAEssGIa.sGPLEDSLFLsHSERLCHGEDRKsVLpKu.PP.EIK.IADM..PLHSPLSRYQSTVISHGFRRRLl.......................	0	4	4	7
+14835	PF14984	CD24		CD24 protein	Bateman A	agb	Jackhmmer:P25063	Family	\N	27.00	27.00	35.40	34.90	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.42	0.72	-8.51	0.72	-4.16	5	28	2012-06-22 15:58:32	2012-06-22 16:58:32	1	1	16	0	14	53	0	51.80	61	65.88	NEW	SNQTTVuTsSs.SSQoTSs...APNPoNATT+uuGGoLQSTASLFVlSLSLLHLY	................SNQT.oVs.ssSs..oSQsTSs...uPNPoNATTKAuGGALQS.TASLhVVS.LSLLHLY.	0	1	1	1
+14836	PF14985	TM140		TM140 protein family	Bateman A	agb	Jackhmmer:Q9NV12	Family	This family of uncharacterised membrane proteins are called transmembrane protein 140. They are found in mammals.	27.00	27.00	68.80	68.60	22.30	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.29	0.71	-4.60	3	37	2012-06-22 16:07:53	2012-06-22 17:07:53	1	2	29	0	20	35	0	151.50	64	96.16	NEW	RPRRt-QLLFMuIMVLVAsVISLMFYALLWKAGNLTDLPNLRIGFYNFCLWcEDTGSLcCHQFPELEALGVPRVGLALARLGVYGALVLTLFVPLPLLLAQCNSDEGEWRLAVGFLAsSSVLLAGGLGLFLoYVWKWlRLSLLGPGFLALGlAQALLILLLMAMVVFPPRAE.KuEs+LESC	............hhtppLLFhuIhlLsssVIsLhhYALLW+AGNLsDLPNLRIGFYNFCLWNEssusLQCHQFPELEALGVPpVGLALARLGVYGALVLTLFss.PLLLA.CstscttWpLAVsFLAhuShLLAuGLuLFLoYsWKWlRLSL.GPGFLALusAQALLlLLLhAhshFP.Rupcs.Sph-sC.............	0	1	1	3
+14837	PF14986	DUF4514		Domain of unknown function (DUF4514)	Bateman A	agb	Jackhmmer:Q5T292	Family	This family of uncharacterised proteins are found in mammals.	27.00	27.00	51.40	50.50	20.20	20.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.03	0.72	-4.16	4	27	2012-06-22 16:13:00	2012-06-22 17:13:00	1	1	17	0	11	30	0	58.40	77	55.09	NEW	DlGGAQVLATGKSAGsEIDhKYAlIGTALGsAISAGFLALKICMIR+HLFDsDSSDL+STs	.DVGGAQVLATGKssGsEIDaKYALIGTAlGlAISAGFLALKICMIR+HLFDsDSSDL+ST........	0	1	1	1
+14838	PF14987	NADHdh_A3		NADH dehydrogenase 1 alpha subcomplex subunit 3	Eberhardt R	re3	Jackhmmer:O95167	Family	This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic [1-2].	27.00	27.00	29.60	29.60	26.20	26.10	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.96	0.72	-4.07	6	72	2012-06-25 07:58:29	2012-06-25 08:58:29	1	2	38	0	27	63	0	76.80	64	83.37	NEW	MAuRluAFLKsAWsKEPVLVVSFsIGGLAlIlPhlSPaTKYosMINpATPYNYPVPVRDcGNMPDVPSHPpDPQGPSL-WLKsL	..............u.luAFLKNAW..sKEPVLVsSFsluuLA.lILP.lSPYTKYusMINp...ATPYNYP................VPVRDD....GNM..PDV.PSHPpDPpGPSLEWLKpL............................	0	1	3	7
+14839	PF14988	DUF4515		Domain of unknown function (DUF4515)	Eberhardt R	re3	Jackhmmer:Q6ZUS5	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.	24.30	24.30	25.40	25.30	24.20	24.10	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.23	0.70	-4.66	11	151	2012-06-25 08:27:04	2012-06-25 09:27:04	1	1	48	0	91	151	0	173.10	28	47.21	NEW	Es+hFLEYLpc+sEcppcph-pLWpsYlQpppEI-c+RpELsScaspppupLpppLhQpcKh.pusL+pcLQAlcsluplKEpQ-pcIpsLccEhcchpu-puhpc+Es+hQFLcEKutLE+Qlp-hchhphGccts+ELppKspAhchtAKphhp-aspulp+ENppL++cLhQLhpEhpcLcsp+p+LEpp+QplpcpQWYLEuL	.......................................hhpaLpppspcppp.hppL.pph.ppptph.p.pc+p.ch.pp...YstphstLc.tphhpppp...s.lppcLpslcphpth.............K.p.-p-lpsLccphtphptcpppphpchctpFhpEKttLEc-s.Epcl..h...Luc+Ac+E.............A.hhtl.phspslhcENhpLpctLh.hhc......csptLptppppL.pcp+ptLhppp.h.p....................................................................	0	23	28	48
+14840	PF14989	CCDC32		Coiled-coil domain containing 32	Coggill P, Hetherington K	kh6	Jackhmmer:Q9BV29	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 188 amino acids in length. The gene that encodes this protein is C15orf57 but its protein product is called Protein CCDC32 (Coiled-coil domain containing 32). The exact function of this protein is still unknown.	27.00	27.00	27.90	34.60	19.70	25.40	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.81	0.71	-4.37	14	92	2012-06-25 08:39:40	2012-06-25 09:39:40	1	2	70	0	54	88	0	137.80	41	74.06	NEW	D.Wsphsss..psppt......pssppFcDsFpsshstt.tptp..................p....tPLsDS-sYLAsLER+Lp+l+uts......chLcoLuptKc-Chc+LLps.....shsspha.ph.-hDpsshpp.L+RaLhP.c.AlsstEl.aLl.h-tLppp	......................D.WsEhssslspstpp.....sssssuFpDSFhss.stsptppps.t.................s.tsa....tPLpDSEsYLASLE+.KL++IKGhs.......p.-VTSK-ML+oLuQAK+ECWDRF.Lp-.........phsuEhF.-s...l-sDcs.......slpp........h+..RaLtP-+sAlospElpaLl.s-t..p.p............	0	13	15	35
+14841	PF14990	DUF4516		Domain of unknown function (DUF4516)	Eberhardt R	re3	Jackhmmer:Q69YU5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 56 and 69 amino acids in length.	27.00	27.00	29.10	29.10	22.60	20.50	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.66	0.72	-8.29	0.72	-4.41	14	71	2012-06-25 08:52:15	2012-06-25 09:52:15	1	2	61	0	43	70	0	47.90	43	66.80	NEW	MPuG.........suhspYhhhhssulhSMhAGAplVHphYKPDLolP.l.scssp	...............MPuG.............VshssYlphhusulluMhAGApVVHpaY+PDLolPpl.sc.t..........	0	8	15	25
+14842	PF14991	MLANA		Protein melan-A	Bateman A	agb	Jackhmmer:Q16655	Family	\N	27.00	27.00	81.80	81.70	23.80	23.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.57	0.71	-4.08	5	35	2012-06-25 09:02:05	2012-06-25 10:02:05	1	1	30	12	22	30	0	108.70	59	98.78	NEW	PRcDhHa..G.aF+G+GRoYsTAEEAlGIGILIVVLulLLllGCWYaKRRSGYKpLhsKoI+lGo.psl.....+sRCspEusc+p-SKlShQEassh.pPVVPNAPPAYEKIAAEQSPPPYSP	.PRE-sHa..GaP+KGHuHSYlTAEEAAGIGILsVILGlLLLIGCWYCRRRSGYRsLhDKol+sGTQs.sl.TtRCspEuhsHpDSKlshQEpss..cPVVPNAPPAYEKlSuppSPPPYSP.	0	1	1	5
+14843	PF14992	TMCO5		TMCO5 family	Eberhardt R	re3	Jackhmmer:A8MYB1	Family	The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.	28.10	28.10	28.30	28.60	27.50	28.00	hmmbuild  -o /dev/null HMM SEED	280	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.89	0.70	-5.27	9	134	2012-06-25 09:09:25	2012-06-25 10:09:25	1	2	26	0	62	136	0	210.10	29	85.47	NEW	NlpSLN.DLE+DhQRlDEANQ.LLpKIpEKE-sIQsLE+EIs.oht.uc-c..E-.Nchs.tE+EpALp-LE.ETA+LE+cNcpLs+slsELQ+Klo++pps.sssEptshcptlpE.K..s+LQp.ppSCAsQEKELsKl.p...DYppVspLCEDQAhhIK.KYQEhL.+chEc.EKEshlLE+ElsKs.sp....sSph..cssSh.hEshtpNhEcshlpKpp...p...........tFWh+hFRh.LhFhVlhFIRLLuYlhFH.lpaINPDLLVc.sLPhlLSRsoLhcLRchlFPFLTLEsE-lLP	.......................................................................................................................sLp.ch-tc.QplsctNp.hL.plp.pEtthppL.....p-lh...t.hpcp..-c...s.h...p.pps.h...h...cp.shLEhps..ph......-lppp..sct..p...h........-t.t......pt..p..c..splp...tphh..p.EpplhKl.p..................-ht...s..tphp..tD...ts..h+....chpE....hL.cphEp.ph-hhhLppc.lphh........t.......s.........p..t..h.ptt...............hh.hphhph.hhh..hhhhhtlhshhhha.h.al....h.p.hLPhhhu+thhhcLRphh.P.LsLpsEthLP.....................................	1	5	5	9
+14844	PF14993	Neuropeptide_S		Neuropeptide S precursor protein	Bateman A	agb	Jackhmmer:P0C0P6	Family	\N	27.00	27.00	89.30	88.90	26.90	15.80	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.44	0.72	-9.13	0.72	-4.30	4	24	2012-06-25 09:09:30	2012-06-25 10:09:30	1	1	20	0	12	31	0	64.00	73	77.25	NEW	YPVssS...KVsGKsDYFLILLNSCPuRl-tS-cLAhLKPILEKsFhKRSFRNGVGoGhKKTSFRRAK	....YPVssS...KVSGKSDYFLILLNSCPoRlDRS-tLuhLKP.ILEKhFhKRSFRNGVGTGMKKTSFRRAK	0	1	1	3
+14845	PF14994	TSGA13		Testis-specific gene 13 protein	Bateman A	agb	Jackhmmer:Q96PP4	Family	This family of uncharacterised proteins are found in chordates. In humans this gene is found to be expressed specifically in the testes.	27.00	27.00	29.40	44.50	20.50	24.80	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.78	0.70	-5.24	5	31	2012-06-25 09:19:14	2012-06-25 10:19:14	1	1	24	0	18	28	0	260.70	55	92.14	NEW	Gs.....KcpoKhQ..sGtSKsuKoSul+FEKpll......sDu-EIhDAVGQSKFVLc................................NLRHYTV.........HPNLAQ.....................YYEPLKPTALQKFLAQN+KI.........................................................pSFMLKVTEYDQDKTLLIMTNNPPPCsIDHQGK-usPKYFSsELL.............LK..EosaQH....KPT-NhaLPpMPQK.............KKL+stLK............PlFPlpLl-DPsSK+EQWFRFSTDcDFKSEGRYSKVYALR+QKKMYPQLsFAPVscRph..........+ssVSKKSuS-sPT........SQVIWEPLTLSSLLEEKPTRTAPGESsFRsGRAQQWIIKsATVI	......................................................................................................................++poKhQ..pstu+h.csssh+hEKthh.........ssscEI.DsVGpSKFVLc................................................................................................................NL+HYTV.........HPNLAQ...............................................YYcPLKsTALQKFLApN+Kh.........................................................pSFMLKVT-YDQDKTLLIMTNNPPPssIspQsK-ssPKYFScELL.............lK....ppp.aQH....KPo-shhLPhMsQK.............KKLRstLK............PlFPlhh.-DPsSK+EQWFRFSTDNDFKoEGKYSKlYALR..pQKKMYPQL...sFAPVpcRph..........+ccsS..hKStSphPh........Sph...hhEPLTLuSLLEchPTRo..sPGcusFRpGRA.Q.WhlcpAsl............................................................	0	4	4	4
+14846	PF14995	TMEM107		Transmembrane protein	Coggill P, Hetherington K	kh6	Jackhmmer:Q6UX40	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 138 and 164 amino acids in length. There are two completely conserved residues (H and E) that may be functionally important and four transmembrane helices. The domains in this family vary in length from 124 to 126 amino acids. The precise function of the protein family is still unknown.	26.00	26.00	26.20	26.10	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.72	0.71	-10.52	0.71	-4.00	37	76	2012-06-25 09:47:02	2012-06-25 10:47:02	1	4	60	0	51	85	0	114.90	39	64.62	NEW	L.lPsRFlslhsHhlhl..lslhauc-pslpush..........hshspt....p........Ysptcp......plsssLslohhhhslEhhGhhoGlShFssspslhphssHsuAuVhL.hFhhppWcssp..hWalFshh.SslPshhEhhhhh	........LVPuRFLoLlAHLVll..ITlaWS+-sNlp.A.sLP.........hpao.p.....p.......................Ysppct.......p.LlsuLuloluhhslElsGhhoGlSMFssopuLl....slssHsuAuVhLshalhcpWcsst..aWalFshh.ShhPshhEhhhh...........................................	0	24	30	40
+14847	PF14996	RMP		Retinal Maintenance	Coggill P, Hetherington K	kh6	Jackhmmer:Q96NL8	Family	RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively [1].	27.00	27.00	27.70	27.70	23.10	23.10	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.58	0.71	-11.37	0.71	-4.28	14	77	2012-06-25 10:04:19	2012-06-25 11:04:19	1	2	67	0	52	66	1	137.00	40	62.04	NEW	LDshls-..........lspcss.ssh.s.phssppsssssshss..s...........p++Cssl.hLuGsphshGlsoshpp......+sCspLRCssCDFcVlpasshcWcpssDYLFFRNNhPchpKLpsKLhpc.GspAYuCQCsWpos..schsslps..spl+WVCuuH	...........................................................sshlp...........h.pp.t..t.......s.p..ts.sstss........................................tppCssl.alGGoshspGluoshsp........RuCDpLRChsCDFtVlpasDhhWDc........S...sD.YLFF.R.NNhP-hpKL+s.......K...............LhccpGsRAYACQCSWpol.....p-lscLpst...ppL+WVCutH...............	0	20	24	33
+14848	PF14997	CECR6_TMEM121		CECR6/TMEM121 family	Eberhardt R	re3	Jackhmmer:Q9BTD3	Family	This family includes Cat eye syndrome critical region protein 6, a protein which has been identified in a screen for candidate genes for the developmental disorder Cat Eye Syndrome (CES) [1]. It also includes the TMEM121 transmembrane proteins. The function of this family is unknown.	25.00	25.00	25.10	25.10	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.45	0.71	-4.70	17	120	2012-06-25 10:07:15	2012-06-25 11:07:15	1	2	66	0	90	116	0	190.60	31	45.76	NEW	saAhl....sWhlY.shsLh.Klshlapshhs-t....h.sh-h.hu.psLclsLulo.shLFlLLltsc+.phspu........p++hhlpshhhtlslDLLDslshlphLhcspt....hsLslhl-shllhhshlsl...hLPsluLhElshsph........t.hspchl.aslLthlhVNlPhlhIRs..hLa.......atpspssSlFhhKNlhhlhhtspphhpt	....................................................................................................................................................................................taAhl....hWhlY.hhsLphKlhhlapshh.tc........................htsh-s..h...u.p..pslplhLuls.l.P.hLalLlsuhs.chphsps........pc+cchpsphhhVsLDLLDhl.s.h......t.Lhcspp............hsLP.lahcslhhhhsalhL...slPslu....LsElshps...........................t.hsp+hh...aslLulhhVNlshlhlRs..hll.......app..p..pssoIFlhKNlhhluh+shphlp.........	0	25	39	65
+14849	PF14998	Ripply		Transcription Regulator	Coggill P, Hetherington K	kh6	Jackhmmer:Q5TAB7	Family	The precise function of this family is not clear, but it is thought to play a role in somitogenesis, development and transcriptional repression. Ripply is also known by an alternative name, Bowline. Bowline, is an associate protein of the transcriptional co-repressor XGrg-4 [1]. This family contains two conserved sequence motifs: WRPW and FPVQATI. The WRPW motif is thought to be required for binding to tle/groucho proteins [2]. Ripply3 is also known as Down Syndrome Critical Region Protein 6 homolog [3].  This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 154 amino acids in length.	27.00	27.00	40.80	39.90	20.50	20.20	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-3.87	16	104	2012-06-25 10:24:52	2012-06-25 11:24:52	1	1	41	0	57	95	0	82.20	50	63.51	NEW	sshWRPWl..osp-stppspt..............stsstpspsspts.sFpHPVRLaWPKS+saDYLYppGEpLLpNFPVQATIshY-.-SDS---EE	.......................................................s.hWRPWl..sst.c...ph..t..............stu..sthstsstt..tFpHPVR.LaW.PKS+saDYLYppGEtLLpNFPVQATIsFY-.D.SDSE-Ep................	0	5	12	21
+14850	PF14999	Shadoo		Shadow of prion protein, neuroprotective	Coggill P, Hetherington K	kh6	Jackhmmer:Q5BIV9 	Family	This protein family is a Prion-like protein and its function is neuroprotective and similar to PrP(C)-like. Shadoo is mainly expressed in the brain, and highly expressed in the hippocampus, the area of the brain which co-ordinates memory as well as spatial memory and navigation. This protein may also alter the biological actions of normal and abnormal Prion Protein (PrP) which lead to lethal neurodegenerative diseases [1]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 150 amino acids in length, of which the first 90 are alanine rich.	27.00	27.00	49.40	49.00	26.30	25.70	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.93	0.71	-4.29	5	54	2012-06-25 10:39:11	2012-06-25 11:39:11	1	1	32	0	11	48	0	121.80	75	86.49	NEW	CDSGAAKGGRGGARGSARGGlRGGARGAuRVRVRPAPRYu..GSSLRVAAAGAAAGAAAGAAAGLAAGSGWRRAsGPGEpGLEDsEDGAPGGNGTGRGVYSYWAWTSGAGPTssh+LCLLLGGALGALGLLpP	.......CDuuAAKGGRGGARGSARGG.....RGAuRVRVRPAPRYu..GSSlRVAAuuA..A.AGAAAGA...AAGLAAGSuWRRAAGPuElGLEDs.EDGAPGuNGTGRGVYSYWAWTSGA...GPTsph...+LC.LLGGALGALcLLRP.......................	0	1	1	3
+14851	PF15000	TUSC2		Tumour suppressor candidate 2	Eberhardt R	re3	Jackhmmer:O75896	Family	This family of proteins are candidate tumour suppressors [1-2].	25.00	25.00	26.90	26.30	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.96	0.72	-10.68	0.72	-4.01	13	77	2012-06-25 10:40:10	2012-06-25 11:40:10	1	1	56	0	45	65	0	102.30	56	97.96	NEW	MGuSsSKt.cuhh.h.ssss.sssss......tssc.p..p.schcshRsusP...FVaoRRGShYaDEDGDLAHEFYEE.lls+sGp++uph+Rlp+N.LpPQGpl+hshPplHVDFPlllC...Es	.......................................MGsSuSKs.+GhWPFsusuussssts..........tssc.p..shscs+s..RsssP...FVFTRRuShaaDEDGDLAHEFYEE.TlV...TKNGpK+AKL+RlpKN.LlPQGIVKLDhPR..IHVDFPVlLhE.V........	0	11	15	26
+14852	PF15001	AP-5_subunit_s1		AP-5 complex subunit sigma-1	Eberhardt R	re3	Jackhmmer:Q9NUS5	Family	This family of proteins are subunits of the adaptor protein complex AP-5 [1].	25.00	25.00	26.00	25.90	20.80	22.60	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.12	0.71	-4.35	10	72	2012-06-25 10:41:30	2012-06-25 11:41:30	1	1	55	0	47	67	0	166.60	42	86.40	NEW	MVhshlIHolp........sps+VLaSphYus-.....tp.pp.shcpcR.hpKEpl....tslA+pVcSpsshp+ps......su+sss-phhp.s-psluhtEts......sGsFplhsG-sFsscphVLWhuVsuluFsLVC-sHENlhLA-sTLRpls+hLhcpl..+sLss....uuclLh.....KuD+lcAlLc+FLPpGQLLFLNcphsptLEKElp	..............................MVpuFLIHTlpss.....tss.sRVLYSphFGs-p.....spp.c.hssEccRlhcKEpl....hsVARQ...VcShspLpppA......uGcssh-htst.u-EslsLpEAs......pGsFpLtsu-PFpps+.sVlWLuVhuLuFsLVh-sHENLLLAEsTLRhLs+hLL-pL...+lLss....usplLh........+uDcltulLpcaLPpGQLLFlNppasptLccch..........	0	15	18	29
+14853	PF15002	ERK-JNK_inhib		ERK and JNK pathways, inhibitor	Coggill P, Hetherington K	kh6	Jackhmmer:Q9H6E4	Family	This coiled-coiled domain, CCDC134, is a secretory protein that inhibits Mitogen activated protein kinase (MAPK) pathways such as Raf-1/MEK/ERK and JNK/SAPK but not p38.  CCDC134 is widely expressed in normal adult tissues, tumour tissues and cell lines, which shows its importance in cell signal transduction pathways, transcription regulation and therefore cell survival [1]. Additionally, CCDC134 is known to bind to a transcription adaptor, hADA2a, which forms part of the general control nonderepressible 5 (GCN5) histone acetyltransferase complex. Acetylation usually 'switches genes on' for transcription. Moreover, knocking out CCDC134 suppressed hADA2a-induced cell apoptosis activity and G1/S cell cycle arrest suggesting its importance in cell survival [2]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 188 and 257 amino acids in length. This family is a coiled-coil domain containing protein 134 (CCDC134) whereby the coiled-coiled domain is a ubiquitous motif involved in oligomerisation.	27.00	27.00	29.10	28.10	19.70	20.30	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.25	0.70	-4.95	8	99	2012-06-25 10:48:46	2012-06-25 11:48:46	1	7	72	0	62	88	0	174.20	39	69.01	NEW	pscsppspsppssssppstKlacclFspKRcEHhpAlcplhplpph-KRhcLlchllcclh+llpcu+ptLEcusasu-.SsFP.c-p.sLpDALupllENTAFFG-LlL+hP-hoccllcpss-WpsLhpWulsaoppos.lL--socchLcLlsQEls.hscRcssYhNPY.......pct.+cphcpppcsphKKKp+Kc......hpKtPpL.....+pEL	......................................cha++hFchKR+-ph.A.lcsLhpls-hpppYKll-lhLcslh+VLc-S+thL.sushh..Pc.ssFP.pDc..plK-AhSpllENTAFFGDllLRFP+IlHphac+s.s.sWs.Ll+Wul.sFCspo...u..la...........s.p..s.p.p.l....LpLhuQELs.lsE+sssa.NPa..........ptc..p.cthptpcppcccccp+Kc.........pKtPpl.....p.....................................	0	22	28	48
+14854	PF15003	HAUS2		HAUS augmin-like complex subunit 2 	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NVX0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 203 and 291 amino acids in length. HAUS augmin-like complex subunit 2 is alternatively called centrosomal protein of 27 kDa (CEP27). It localized in the microtubule organising centre, the centrosome. These microtubules are part of the cytoskeleton and give the cell its shape, provides it with a platform for motility and are crucial for mitosis [1].  This protein is part of the HAUS augmin-like complex. This interacts with the gamma-tubulin ring complex (gamma-TuRC) which is required for spindle generation. HAUS2 may also increase the tension between spindle and kinetochore allowing for chromosome segregation during mitosis [2]. This protein is involved in mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis.	27.00	27.00	27.00	27.10	22.30	26.00	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.87	0.70	-11.68	0.70	-5.33	7	100	2012-06-25 10:53:06	2012-06-25 11:53:06	1	3	62	0	56	102	0	194.40	34	89.31	NEW	sssWsstp.h.phuGhh.uh.lASslshp.h.s.Spcss.shs............hphLpploslQtcIhphplElphhK.-KssAcLsHso.ht+KhcsLt..phsshLcsVlppK-cIhtRL.pPhsh-ClPlEAcYp+phsc...............LLhhAso.hutLpsslpshp...phc-s.phhuchLt.hslhlspspchhEsl.thREp.tplpphhsth.s.p..lp..........................................................................+clshPP.shpsp	........................................................p...phuuh..sh.lAushh.t...s..spcp..shs............hphLpploslQtcIhphplElphl+h-KcsADlsHs.hltpKhcsLp..phsspLcsVlppKcplhpRL.pPh...st-sLPlEA.Yp+.hsc...............LL.hAss..h.ttLpsplpshp...ph..pts...p.h...sphLt.hshhlspspch.hEsh.thRcp.tph....s...................................................................................................tt............................	0	11	22	32
+14855	PF15004	MYEOV2		Myeloma-overexpressed-like	Eberhardt R	re3	Jackhmmer:Q8WXC6	Family	This family of proteins is found in eukaryotes. It includes human myeloma-overexpressed gene 2 protein. Proteins in this family are typically between 45 and 74 amino acids in length. There are two conserved sequence motifs: MKP and DEMF. The function of this family is unknown.	27.00	27.00	27.40	28.80	23.30	22.80	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.63	0.72	-9.06	0.72	-3.42	8	78	2012-06-25 11:40:17	2012-06-25 12:40:17	1	3	63	0	48	69	0	57.70	71	54.98	NEW	MKPulssDEMFPEGAGsYMDL-E.......uGGuoGhhhD.L..sANEKsVHuDFaNDF-DLFDDD............sh.	....................MKP.uV...DEMFPEGAGPYVDLDE..........AGG.STGLL.MD.L...AANEKAVHADFFN................DFEDLFDDDD.....................	0	7	9	27
+14856	PF15005	IZUMO		Izumo sperm-egg fusion	Coggill P, Hetherington K	kh6	Jackhmmer:Q6UXV1	Family	Izumo is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization [1].  There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204) [2]. There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific [1,2]. This family of proteins is found in eukaryotes and are typically between 193 and 305 amino acids in length.	27.00	27.00	42.40	41.80	22.60	22.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.18	0.71	-4.19	8	129	2012-10-03 02:52:13	2012-06-25 13:02:24	1	2	29	0	53	139	0	145.10	28	60.57	NEW	aGu+GCLpCDPphlEslspLcusLlPpch.VsshpthhptlhppMpchhF+shthsshluhlslppL-clsoalKschp+LtssohKsshllp.ELlslRcplh+cLcchL+saphc.sCsccCtlhctslLDChsCp+hos+Ch+ucaCtc-c.p+sph+	....................................uhGCl.Ccsph.-thp.hcpphhspph..s.tp..htshhphlhpthcshhhpsat.s.uhhuhlspppL-pluphlhpphppLhpsshpsshhlp.ELhslhcpthcplppsltpaphc......hC.ccC.slht..hl.C.sCpc.hhtCh.uh.Ctppt....thp...........................	0	4	4	8
+14857	PF15006	DUF4517		Domain of unknown function (DUF4517)	Coggill P, Hetherington K	kh6	Jackhmmer:Q9GZN8	Family	The function of this protein remains unknown. This family of proteins is found in eukaryotes and are typically between 160 and 182 amino acids in length.	27.00	27.00	30.50	30.00	23.70	24.30	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.19	0.71	-4.38	16	94	2012-06-25 12:06:34	2012-06-25 13:06:34	1	2	70	0	54	82	0	136.30	48	83.71	NEW	p+HVHFDpp.......hHDssl.............h.hp.pscu.shhV+lGFLplpHRYcIchslPs.s.hhs.....ts.sshs....slPshps+ll.....shs.....ssssscp.hcshlEahAaKEtlL+EcltLsuppssspplcllltARVLu+t+GTPML+sGIHClGVEh-.p-S.EtSDWpGFc	..............................................................................ppHVHFDpp........h+DS.sV..............hspppuDs.sh.lV+lGFLpIhHRYcIsFoLPs.s.hhs.....pshpphs.....sPslHl+lh.....sls......hsEt.....hphEa.AaKEtlL+EchhLsspsss...........spplplhlpARVhs+p+GTPMLhsGl+ClGs.Eh-..-S.EtSDWtGFD...........	0	18	22	36
+14858	PF15007	CEP44		Centrosomal spindle body, CEP44	Coggill P, Hetherington K	kh6	Jackhmmer:Q9C0F1	Family	CEP44 is a coiled coil domain found localised in the centrosome and spindle poles.	27.00	27.00	28.00	27.00	24.40	24.10	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.65	0.71	-4.44	13	98	2012-06-25 12:15:38	2012-06-25 13:15:38	1	3	67	0	57	87	0	127.10	46	34.24	NEW	Dl+ssLc+LcptLRslpYP.....tclDhstLcpGDPuAhLPllcYsLhsYSppluchLlcpGaE......L..hu.KoDLRFlEslaKlLR-pFsY+PhLotpQFhp.pGFAE+KlhllsDIls...hlhc+H+Els+tp+tpspphpp	..............DLKpsLRpLEpsLRhLsYP..............p-VDhsGLhKGDsuA.LPIISYuhTuYSshVsElLh-.s.slE......L..hu.KNDLRFl-sVYKLLRDpFsYKPlLTKpQFlp.sGFAEhKIpIlCDIls...tVhKKHKELsphpKh.spttpc.....................	0	22	30	38
+14859	PF15008	DUF4518		Domain of unknown function (DUF4518)	Coggill P, Hetherington K	kh6	Jackhmmer:Q5JPI3	Family	The precise function of this protein family is unknown but it is thought to be involved in apoptosis regulation.	27.00	27.00	37.10	31.80	26.40	26.20	hmmbuild  -o /dev/null HMM SEED	262	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.75	0.70	-5.35	14	96	2012-06-25 12:29:39	2012-06-25 13:29:39	1	4	68	0	56	90	0	239.00	41	84.87	NEW	LS-pc+pGhR-LLtphss.ssLhpLscoVTppllc..l-sp-EAlchIlsaopsspcLL++++IpR-lLF+YLtp+tsssssshsKssLlp+llpaWppphstp......spps.ppsptstpsth..t..............tppp.slchLAccFscWFFshLNu.............-shu.pcFWsDssL+lphhss-tss-ph..puAptV.ptLlultpp.thhFNPNLspsGlpGph-saGhVlVhssGTlHpsppClGlFEpsFGLlRDP....hssNNWKhKpsclpL+upt	..................................................St.EhpGh+pLLt.hcs...splhuLscTlTsp.llp..spspp-AlcAILsYSpsscELL+R+KVpRElIFKYLuspulhlsPso-KpsLIp+shpaWppp..p.p...................hppsspss...ppp.....pp.p...pp..............................................................ptpphs.hppLuccFspWFFtlLNu.t...............spaGPpHFWpDspL+h..h..h..psu....-p.ss..ch....pGAp.Vuh+LluLspp-hlhhsPNLsspGl+st.ssHGLVhVtVsGTlHc.....s.s.......s.......C.LGIFEQlFGLlRsP....hhpNsWKIKhlplplhup.s...............................................	0	14	18	32
+14860	PF15009	TMEM173		Transmembrane protein 173	Eberhardt R	re3	Jackhmmer:Q86WV6	Family	Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA [1-4].	27.00	27.00	62.70	35.70	19.30	19.10	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.29	0.70	-11.89	0.70	-5.62	16	77	2012-06-25 12:34:37	2012-06-25 13:34:37	1	2	63	7	51	89	0	271.20	37	83.39	NEW	chlpplsh......h..hh.thChhs.p.hppha.h.csphWpll+psashshpsshhhhuhllluhhhassssshssls.shhhh......hp................lsppsLoahlhl+psp......h...tls...sL....shAsGhAhSYaaGYL+LlLP........uLpcRhcpapcppN...hphss+RLaILlPp-shVsssl..p..ss..hlchtcsLpsphlsRAGlctRsY.KpuVY+l...tcctsspshhhshEhATPLlThach.pp..usshhh+E.+pE.hhhFh+pLc-lLp.....shPEo+spscLIhYssh.-sp.Gs.hsluclllp+lcpppc	.........................................................................hhhh.h.ls.llpt..h..C...ht.p..hpphp.h.psp..hhphhptshshs.tth....hhhl..lshhhh..h.phssh..s..h.hhhh.......................hhsphLshhlhlpt..t..............h...ph.tls..tsh....shApGhAaSYYhGYL+LlLP........GLptRIptY.pppps........hshss+RLaILlPhcshVsssL...p.sDs....slchhcpLsppphsRAGl+sRsY.pNolYcl....hcssppshhCllEhATPL.TLFsMspp..upuuhu+EpRhEQsplFhRpLc-ILt.....ssPEspspscLIlYp...-st.usphslup.lLpHlpppp................	0	11	14	32
+14861	PF15010	FAM131		Putative cell signalling	Coggill P, Hetherington K	kh6	Jackhmmer:Q96AQ9	Family	The precise function of this protein family is unknown, however studies have shown it undergoes Protein N-myristoylation; a type of lipid modification in eukaryotic and viral proteins. Protein N-myristoylation is usually an irreversible co-translational protein modification which is useful in cell signal transduction pathways [1]. This indicates that FAM131 may have some sort of role in cell signalling due to its ability to be myristoylated. This family of proteins is found in eukaryotes and are typically between 257 and 361 amino acids in length.	27.00	27.00	32.10	31.90	20.50	20.30	hmmbuild  -o /dev/null HMM SEED	293	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.95	0.70	-4.66	5	167	2012-06-25 12:34:48	2012-06-25 13:34:48	1	2	38	0	87	138	0	229.00	44	79.80	NEW	VEDTluMLPKSRRALoIQEIAALARS...ShpGISQVVKDHVTKPTAMAQGRVAHLIEWKGWuKPsD.....oPpAl.cSDFsSYSDLSEGEQEARFAAGVAEQFAIAEAKLRAWSSVDGEDso--SY-EDhusNa-ssoQpLhpst.....t.lhpsphsShPpphsSps..s.sSpss.E..hSs-oLsAS.sohs..........sp...hs........stpGuuup.uuphL...ts...tsGElpLA+uPsppcpsAh+tht....sscpDSssYssshoEouLSPtE-......Dptsh....ss..pEh.huachsR+VSDVoSSGVpShDE	......................................hLP+.+.Rs..shhtIuALA+S...SL.s...GIS...pshKDHVTKPTAMAQGRVAHhIEWpGWuKsss..................u.tsh.cp-hsuYSD.LS-GE+EAR.F.......AA..GVhEQFAIuEAsLhAWSShDGE-.s.s.sShp-s.hs..tt.p.......................p..hhps.h...shs.hp.su.t...s.sSpss.....sspolhuS.sshp..........................................t..s........h...........t....h.p......................................................................................................................................................................................................................................	0	4	13	36
+14862	PF15011	CK2S		Casein Kinase 2 substrate	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NX04	Family	It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterised. It is found to be localised in the nucleus and cytoplasm [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	27.10	27.50	25.50	25.10	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.87	0.71	-4.46	18	90	2012-06-25 13:10:52	2012-06-25 14:10:52	1	3	72	0	58	89	0	155.10	31	72.95	NEW	ppL+ptFpslcpppctWpuslscstsLluSLusLsEQLpAhpclphtss..LcsFPsLppRLptK.htAl-tlLscLsEcLspLpcVpcsluptlpsshplYcpph..ssLslssshpRuulsPSlADhLEaLQDl-RaYRppalp++.lLpsLshcsLsshpuhs+pW	..............ptl+ppF.hlccppshWpsshpcs.shlsuLusLsEQLpAhpslc....htsss.LpsF....P.sLp-RLhtKQht.......Ah-hlLspL.tEpLspL.pVpcslsptlcpshplhcpps..sslslc.slhptuulsPSlADhLEWLpDl-RaY+p.p.........Y..lp+c.lLssl.phs..sLsshpuh.pth....................	0	15	25	41
+14863	PF15012	DUF4519		Domain of unknown function (DUF4519)	Eberhardt R	re3	Jackhmmer:Q9NRQ5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between  and 59 amino acids in length. There are two conserved sequence motifs: KET and VLP. There is a single completely conserved residue P that may be functionally important.	27.00	27.00	54.70	54.50	21.60	21.20	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.13	0.72	-8.76	0.72	-4.05	12	70	2012-06-25 13:22:02	2012-06-25 14:22:02	1	2	63	0	47	63	0	55.60	62	84.22	NEW	MRQL+.GKsKETpKpK+ERKp-.hEhpp+lhTVVLPslushhlhIlVaVYLKTRPp	.MRQLKGp.spKETsK-KKERKpshpEu+QQIsTVVLPTLAVVlllIVVFVYlsTRP.....	0	10	12	28
+14864	PF15013	CCSMST1		CCSMST1 family	Eberhardt R	re3	Jackhmmer:Q4G0I0	Family	This family of proteins was discovered in a screen of Bos taurus placental ESTs. The B. taurus member of this family was named cattle cerebrum and skeletal muscle-specific transcript 1 [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 97 and 157 amino acids in length. There is a single completely conserved residue D that may be functionally important. The function of this family is unknown.	26.10	26.10	29.20	27.50	26.00	26.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.67	0.72	-4.06	15	66	2012-06-25 14:36:52	2012-06-25 15:36:52	1	2	57	0	39	66	0	74.40	37	49.36	NEW	scpPl+aooSpAu..+Wcsppohusspsc...PWapsalluhSlsshllYFCllREEsDlDptLc........psLh-c.l.uLEcpphp	...scPI+FSuSpAs........pWpspcohutsppc...PWapshslSsSLsshlla.ChLREEoDlDphLc........psLh-p.l.t.pp....t.........	0	13	15	26
+14865	PF15014	CLN5		Ceroid-lipofuscinosis neuronal protein 5	Eberhardt R	re3	Jackhmmer:O75503	Family	\N	27.00	27.00	33.60	53.90	18.50	21.50	hmmbuild  -o /dev/null HMM SEED	303	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.13	0.70	-5.06	4	59	2012-06-25 15:14:48	2012-06-25 16:14:48	1	2	42	0	40	54	0	283.40	61	85.46	NEW	ppWPVPYKRF-FRPcsDPYCQA+YTFCPTGss...IPVMK--DlIpVaRLQAPVWEFKYGDLLGHhKIMHDAlGF+SoLTGKNYTMEWYELFQLGNCTFPHLRPsMsAPFWCNQGAACFYEGIDDsHWKpNGTLVhlupIS.GsMFNcMA+WVKpDNETGIYYETWTVpASP-tsSssWFDSYDCSpFVLRTYpKLh-LGApFs.KspTNYT+IhLYSGEPhYLGN-TSIFG.oGNKoLAhsIRcFYYsF+PHpSh+EhllSLLcIh-+Vllc+pFYhFYNhEYWaLPMKFPYlKlsYEEIPLP	............................WPVPY+.RFsaRPcsDP.YCQ.A..+YT.F..CPTGSs...IPVM+s-DlIEVaRLQAPVWEFKYGDLLGHlKIMHDAIGF+STLTGKNYTMEWYELFQLGNCTFPHL....R..P-...hsAPF....WCNQGAACFFEGIDD.hHWK....EN....GTLlhVATIS.GshFNpMA+WVKpDNETGIYYETWsVpASPp..+sAcsWF-SYDCScFVLRTapKLAEhGA-F.K....pI-T..NYT+..I.FLYSGEPsYLGNETSlFGPsGNKTLuhAI++FY..aPF+...P.HhSsKEFLloLLpIFDsV..Il++pFYLFYNFEYWFLPMKaPFlKITYEElPLP.......................	0	9	14	22
+14866	PF15015	NYD-SP12_N		Spermatogenesis-associated, N-terminal	Coggill P	pcc	Jackhmmer:Q9BXB7	Family	NYD-SP12, also known as SPATA16, is a germ-cell specific participant in the Golgi apparatus, and its expression is confined to spermatogenic epithelium, not being found in interstitial cells [1]. Computer analysis of the protein-sequence showed that NYD-SP12 contains a cluster of phosphorylation sites for protein kinase C as well as for cyclic nucleotide-dependent protein kinases [2,3]. It is postulated that since the mutation of some Golgi apparatus’ proteins are responsible for male infertility that NYD-SP12 might play a role in modification and sorting of acrosomal enzymes [3]. OMIM:102530.	27.00	27.00	27.30	36.70	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	569	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.15	0.70	-12.83	0.70	-6.28	3	107	2012-06-25 15:20:51	2012-06-25 16:20:51	1	1	36	0	24	105	0	196.80	46	99.32	NEW	MDSGsSRSLEsoVsRlY+DpLLPKINTSKKMSTLssuP...sILEsopEIKKNsG-tQVEsosERlKhTKoIKEKQSNDLEKAAhKRKAEuEEK.sGKKEAKIhELDNQLl.TsPLPHIPLKNIMDVEMKLVYlDEp-VuYEFApPsMspGpQsTsQsAphsDPsSs+shSsLPQIDKWLQVALKDASSCYRQKKYAVAAGQFRTALELCSKGAALGKPF-AaAEDIASIASFIETKLVTCYLRMRKPDLALNHAHRSIVLNPAYFRNHLRQAAVFRCLERYSEAARSAMIADYMFWLsGGoEcSISKLIKLYWQAMIEEAITRAESFSVMYTPFATKIKsDNIEKVKDAFTKTHPuYs-aIYTDsQGLHlLPQTsDWSSFPPQQYLLTLGFKNK-DGKFLEKlSSRKLPIFTEHKTPFSPLTREDTVRQMETlGKRILPILDFIRSTQLNGsFsACSGVMEKLHYASLLSRLQRVKEQSQVINQAMAELATIPYLQDISQQEAEL...LQSLMADAMDTLEGRRSDKERVWNpIQKVGpIEDFLYQLEDSFLKTKKLRTARRQKTKMKRLQTVQQ	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	2	3	7
+14867	PF15016	DUF4520		Domain of unknown function (DUF4520)	Coggill P	pcc	Jackhmmer:Q96MH7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.	27.00	27.00	27.00	27.70	26.80	19.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.89	0.72	-4.41	13	57	2012-06-25 15:24:44	2012-06-25 16:24:44	1	3	53	0	36	59	0	90.00	38	13.52	NEW	ushsssVlp-sslsGsGpFhAYoDG+VRshFsDRshLsLsh..pt...................spshscllhPDGppshlplsps...sshccY..VssAlpas+as	........s.hhslllp-ShIsulGRFhAYoDs+V+ulFhDthhLoLsashss................................shuhC+LshPDGppplIplp+P...tsac.RY..VssslpasRh.........	0	8	14	21
+14868	PF15017	AF1Q		Drug resistance and apoptosis regulator	Coggill P, Hetherington K	kh6	Jackhmmer:Q13015	Family	AF1q is an oncogenic factor involved in leukaemia development, thyroid tumourigenesis, and breast cancer metastasis. AF1q plays a critical role in the regulation of apoptosis and drug resistance. Initially identified as a mixed-lineage leukaemia fusion partner (MLL11) in infant acute myelomonocytic leukemia carrying t(1;11)(q21;q23) translocation. It is located in chromosome 1 band 21 [1]. AF1Q may be a novel mediator of metastasis promotion in human breast cancer through regulation of the MMP pathway and RhoC expression [2].This family of proteins is found in eukaryotes. Proteins in this family are typically between 25 and 482 amino acids in length.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.77	0.72	-10.30	0.72	-4.08	10	164	2012-06-25 15:33:04	2012-06-25 16:33:04	1	8	61	0	89	141	0	74.70	26	19.11	NEW	+sspps..pssssppP-stEFSSFhFWRsPLPsI-c-LhEhL.scthssss.........stp-pc..................t-ccp--s-sDssGWITP.SNIKQIQp-	..............................t............t.p.ps.p.asSFhaWRsPLPsIDh.s..lE.hL.....h.sp....ps...........................ttcpp.....................................................................................................................................	0	8	16	38
+14869	PF15018	InaF-motif		TRP-interacting helix	Coggill P, Hetherington K	kh6	Jackhmmer:C9JVW0	Motif	This highly conserved motif is thought to be a transmembrane helix that binds to transient receptor potential (TRP) calcium channel. It is known that proline-rich proteins inactivate tannins found in food compounds, and it is putatively thought that PRR24 does too. This is important since tannins often inhibit the uptake of iron [1].  InaF is a protein required for TRP calcium channel function in Drosophila [2,3]. TRP-related channels have been suggested to mediate store-operated calcium entry, important for Ca2+ homeostasis in a wide variety of cell types [3].  The amino acid sequence of PRR-24 contains two completely conserved Y residues that may be functionally important. This domain family is found in eukaryotes, and is approximately 40 amino acids in length.	20.00	20.00	21.50	21.00	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.52	0.72	-7.64	0.72	-4.50	26	111	2012-06-25 15:53:43	2012-06-25 16:53:43	1	3	57	0	78	107	0	37.50	40	22.29	NEW	spKhlRlhTVluYlhuVSLuAlhLolYYhFlW..ssshts	...pKhhRllTVh.sYlhuVShsAlhLulYYlFlW..-ssh.....	1	24	30	61
+14870	PF15019	C9orf72-like	FTDALS;	C9orf72-like protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q96LT7	Family	The precise function of this family is unknown but members have been found to be localised in the cytoplasm of brain tissue. Defects in the gene, C9orf72, are the cause of frontotemporal dementia and/or amyotrophic lateral sclerosis (FTDALS) which is an autosomal dominant neurodegenerative disorder. The disorder is caused by a large expansion of a GGGGCC hexa-nucleotide within the first C9orf72 intron located between the first and the second non-coding exons. The expansion leads to the loss of transcription of one of the two transcripts encoding isoform 1 and to the formation of nuclear RNA foci [1]. This domain family is found in eukaryotes, and is typically between 230 and 250 amino acids in length. There is a single completely conserved residue F that may be functionally important.	27.00	27.00	39.70	32.90	20.50	20.10	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.23	0.70	-5.12	18	93	2012-06-25 15:54:28	2012-06-25 16:54:28	1	2	61	0	64	77	0	237.90	45	51.15	NEW	p.ls+hsLus.hppppsthsshl.sphhplsppslhlhuhlF.h.spsspp...shauloll..lsppclpthhphhpslppphpplstph+thhpp.....................ppslpchss.ltphhp............hlsthhpsslhs..........hpItsoshs...............FhupsloSHLpTQhsolI.usshcpspphhshLuhFhhstphphSphphpss......hpssLaLQslpcpssss....hphllp.ppPhThIcLcpcpVhposshcppp	................................pFLAppTLssEIh..csupsssl-sKFaVLsE+ullllS..hIFsu.shsGc+...........sTYuLSlI..LPpoc.LuaYLPLHplCs-R......Lscll+K.sRlhhpK..............................pupslIsh...LTuEllslMc............LLuSh+oauVscc.........I-Is-TlLND-cIus.........psapsFLhpAISSHLQTsGCSVVVG..SssEc..VNKllcTLsLFLTPsER+CSRlsps-up.............pYpsGLFlQGLLK-uoGShshPhcplhhuPaPTTaIDlDhs.TV+QhPPpHEHh.....................	0	28	33	46
+14871	PF15020	CATSPERD		Cation channel sperm-associated protein subunit delta	Eberhardt R	re3	Jackhmmer:Q86XM0	Family	The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex requires several auxiliary subunits, including CATSPERD. CATSPERD is essential for the cation channel function and may play a role in channel assembly or transport [1].	27.00	27.00	32.60	28.20	18.50	23.70	hmmbuild  -o /dev/null HMM SEED	733	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.27	0.70	-13.31	0.70	-6.52	7	107	2012-06-26 07:21:54	2012-06-26 08:21:54	1	4	32	0	57	111	0	504.10	29	86.63	NEW	.l.ss.hhhssstpclhtpsschp.shhhshplhLThs.hpss.lPhhlPhSh.sGsP.lsShch.suShlLLVsstcsa.hs.phpoWop.pu..c.lScsptc.................................................................sssaots.hhlshos.hFAhlpssph.ps.lhhSssushphpphpYstps..lusLhuhhphpohopsh.lllhspshtpapYpDasLshoh......cshLphhht.uthshLllWsc+slhhuhpshplstsVpshpGptsL.SSlscuslhhpslsss.s-lsVhhcpNslaYuplsI..oshlKhtt.s.aopcsslhFsssGplplLhslcD....uhsappshs.l.th..ssphphshC.h.hhpsphhsphYplDhsppLplhA.hl...shuLhslV.s.sP+.Lshpssl.aE.u....G.sp+pLsIphpQppcatpsDs.FpsphK+sslsslplc.ushphoCsshK.hsh.IuVGCD.pK+IslQs.phSuC.........LpcsaSYlIEK-hhc.....ppsSccLcVpYpapchGCPLhl.asp.a+PVVELac-sta.Ell-ApallhElpGh.sYoashThppusChspsQsWsohhc.sht..h..sWs.ENYhsCas.shspP.t..s.PYpILsupstN+llas.p+sGhYlFhlpIlDP.YSaCpLpThFul.saGhhPhs.h.hssshlhllhhhhholhl..................hshhhhpRhh	...........................................................................................................................h.........h.....h.............h..................................................................................h.........h....................h.h.hs.....t.h.h..t.....th.h..h.........t.hh.h.......p...hh......ptt...a...ph.h...s...........pt.h..hh..u.hs.hlhh.p.phh...pth.....h.h..t.......h..tt.hht.hh...s...phh..hhh..s.h.ha....phth..p.hhhh......s.p...shhhhptsG.h.hlhsh.s....hh...pph..h.th....s..tht.C.h..hhpsph...hahlDhtptLphhs.hl...shu.h.......l......l.s.sPc.Lt.ptph.aE.uh...G.sphpl............plhhhQp.pa...tthps.Fp.p.ppsshshlplc.sphth.Cs..p...sh.luVGCs.pKhIhlps..phptC...........hpc...sasalI-+.phhc.....pp.....pcs...lt...V.Y.hpphGCPlhl.asp.a.pPllpLacpsta.c.ltspallhElpGh.sYoas.Thtpu.hChppsQsWpohhp..p.t.........h..hWs.pNYhpCas.s.sts.h..s..YpIlstpst.Nplhas..t.sGhYlFhlpllDP.YSaCpLpshhul.shG.hs...h...h....hh..hh..hhh.hhh...................................................................	0	10	10	23
+14872	PF15021	DUF4521		Protein of unknown function (DUF4521)	Bateman A	agb	Jackhmmer:Q8IYI0	Family	This family of vertebrate proteins is functionally uncharacterised. The family includes the Chromosome 20 protein C20orf196.	27.00	27.00	67.40	67.30	23.20	22.20	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.19	0.71	-4.73	5	40	2012-06-26 08:56:18	2012-06-26 09:56:18	1	1	28	0	21	29	0	170.30	61	98.08	NEW	MAoQEATPGSpSEESSsLDLPSVCDIRDY.lLQRPSQEosSEAFSSlEupShPsSSDVDPDoSNLNTEQssSWTSENFWLDPSVKGQsETKEEDDGL.....RKSLDRFYEsFuHPQPGSuNPLSsSVCQCLSQKIoEL+GQESQKYALRSFQMARVIFNRDGCSILQRHSRDAHFYPlcEGSoSL-DEKPTPGLSKDIIHFLLQQNVMKDp	..Msup-ATsuS.hSEES.S.sLDLPSsCDIRDY..VLQ+PSQEAsSEAFSSlEhaShPsSSDVDPDoSsLNsEQss.SWsSENFWLDPusKGQsE.ppEDDGL.....RKSLD+FYEhFGpPpPuStssLSASVCpCLSQKIopLcsQESQKYALRSFQMApVIhsRDGCollppHs+-s+FYP.t-Gssul-ccc.sPGLSc-llpFLLpQshhKc.......	0	2	2	4
+14873	PF15022	DUF4522		Protein of unknown function (DUF4522)	Bateman A	agb	Jackhmmer:Q96KX1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. In human this protein is known as C4orf36.	27.00	27.00	34.70	33.20	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.84	0.71	-10.67	0.71	-4.38	3	26	2012-06-26 11:36:54	2012-06-26 12:36:54	1	2	18	0	11	23	0	97.20	68	81.83	NEW	MAYGLPRKNTVKTILRGSCYKVQEPWDLALLTKTWYTNLANIKLPFLEEIoFGSPVpLpKspTpK-spLPSAESIKLEREYEsKRLsKLKCQENVuKEIQhSLRERPVGLRRPLPPK	MAYGlPRKNTVKTILRGSCYNVQEPWDLALLsKTWYoNLANI+LPFLtEIsFGuslpLpKspThK-uLLPSAESIKLEREYEhKRLscLKsQENsucEIQh.LRcR.sGLRRPL.sK..............	0	1	1	1
+14874	PF15023	DUF4523		Protein of unknown function (DUF4523)	Bateman A	agb	Jackhmmer:Q7Z4U5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals.	27.00	27.00	29.10	36.10	26.70	24.70	hmmbuild  -o /dev/null HMM SEED	166	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-11.13	0.71	-4.73	4	34	2012-06-26 11:58:47	2012-06-26 12:58:47	1	1	22	0	14	28	0	139.70	58	77.70	NEW	NLHKLLPN+LMElLaSa+SEEDK+KCENsEFSGLERILtRHQhPKEINLTPKPSpMPLW+RKh.NNhspGWKKC+LWsKsTKEPPMSTIVVRWLKKNMQPoEDLcSVhpRLSsFGPIpSVTlCGRQSAVVVF+DhsSACpAVoAFQSRsPGoMFpCuWQQRFMSK-	......................................NLHcLLPN+LhEhLaSh+SEEDKcKCE.NPEhSGLERILARHQLPKEINLTPKPs+MPsWKRKIINNlo-GWKKCHLhc+NhKEPPMSTIVVRhL.pKNh..pcsL..+sl.p+LpthsshtpsT.sG+ppshV...................................................	0	2	2	3
+14875	PF15024	Glyco_transf_18		Glycosyltransferase family 18	Eberhardt RY	re3	Jackhmmer:Q09328	Family	Enzymes belonging to glycosyltransferase family 18 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase) contribute to the creation of branches in complex-type N-glycans. This domain is responsible for the catalytic activity of the enzyme [1].	26.00	26.00	26.60	26.20	25.20	24.30	hmmbuild  -o /dev/null HMM SEED	559	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.97	0.70	-12.84	0.70	-6.17	11	229	2012-06-26 12:02:26	2012-06-26 13:02:26	1	8	75	0	150	195	2	376.20	35	73.28	NEW	CYA.-aGVD.GS.CSFllYLSEVEsaCP.h.tRt+ps.....s.......pp..sslRcslt.L...h...pcsphpah+pRIpRhWspWlpAucp.Lpc.ppshppR++h+lLValGhLusEsuh+huppuhpGGPLGELVQWSDLluoLplLGHpLclSsspspL+ulls.hhstspssssssscpphDLIaTDIhGLs.h+pphs.hhh.pa+C+lRlLDSFGTEs-FNhpsYspppsh......ppp..WGuasLphpQahTMFPHosDNoFLGFVV-pcs...........ps.++pspul.....VYGKctYMWc..spcchlcllp+ahclHATVss.tp.....pslPoh...VpNHGlLsupElppLL+csKlFlGLGFPYEGPAPLEAlApGsVFLNsKFcPP+SRhNpcFFc-KPTlRclTSQHPYsEtaIGcPHVhTVDIsNpc-lEtAlKcIlphK.lcPalPaEFTspGMLpRVsshlpKQsFCsp.s...................pWPPlsAL+lhtuspup.SCcpsCpspsLlCEPoaFPhINsppthp+...phsCsuscspss..lAPuh.....sCslQussLLFSCAussP...phpRlCPC	.............................................................................................................................................................................hhh.Rh.th.........Wh..u....ht............................thplhhh.t.h..t......h...s.pGGPLGEhlQWsDl.ssL.hlGHtl.hs.p..ph.........................hhh.Dh.G...hpt.....h.......pC.hRllDoFGTcstash..h............tt...aG.hshp..Qa..ThaPHo.s.D..N.oFhGFl.pp..................p.ht..ullYGK.t..h.a..p.......sp......p......h.....lthl....pp.h..h.plH...uTV.....t..........hPsh....lpNHGhlst.-h..LLpcs.+lhlGhGFPhE.GPAPlEAlu.Gs..hFlps...chp...s.csp.s.thh..................tK..Ps.R.c..h.SQpP.Yhp.hlG..PaVhslshps.tthctslpthht..p..h.................p....PahP....h.....EaostGhLpRl.thhlpp.p.....h...............................................aP.Ph.ps.lph.hhu.....up.uC.psC..ppthhC-PshF.hlNppp.h.p...hth...Cps.......p.............................p....h.............hP.........t...........ttChh.p...tp..l..aSCsutt.......phpRlCPC................................	0	54	67	108
+14876	PF15025	DUF4524		Domain of unknown function (DUF4524)	Coggill P	pcc	Jackhmmer:Q96MH7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.	19.50	19.50	19.70	19.50	19.20	18.20	hmmbuild  -o /dev/null HMM SEED	148	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.81	0.71	-4.73	7	59	2012-06-26 12:02:50	2012-06-26 13:02:50	1	3	49	0	40	58	1	132.60	45	25.25	NEW	phllhsD-pVpspasDGspLpLSPCGStFlhEptss.stHPLptscpl+QRT+FslSpa+pplhpAL-FRNpasspPaLsppllpsE....Rptphhscloclc.WPssssss....hpstpsGpVploSlDGhApLhLsppQcEFTVcFlC+lup	......................................Mlla-D-SVpVpYhDG...opLpLSPC....GoEFlhc+sss.u............sHPl.ptscRlRQRTcFslSsa+ppl.pAL-FRNp.us......p.P.a.LspplIss.-...............+Kp.....p.lhhc.....hoEsc.WPs.ssss...........thhh...hpsGpVcIsSlDG+AhLsL.spsQcEFTVcFLCKlSp................	1	8	13	23
+14877	PF15026	FAM74		FAM74 protein	Bateman A	agb	Jackhmmer:Q5TZK3	Family	This family of uncharacterised proteins are found in humans and are known as FAM74 proteins. Members of this family contain several short protein repeats.	27.00	27.00	31.40	48.50	25.10	22.40	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.11	0.71	-4.50	2	11	2012-06-26 12:07:12	2012-06-26 13:07:12	1	2	3	0	8	9	0	84.70	64	100.32	NEW	MWRELRGCPGGDVETAQRLSQRRRGKSSEAVPEKTWRAQRMSQRRRGESSEAVPEKTWKELRNSETVPEKTWKQLRtCLQEDVpRVQRLShhhHhts.hhlhhth.hp.pGs+..ssTaL...hhht	........cLRsCPGtDhETAQRLSpRRRGcSSEAVPEKTWRsQRhSQpR..cSSEsVsEKTW+p...SEsVsEKoW+pL+tC.pEDVpRVQRLS.hhHhts..hlhhth.hp.pGs+..ssTaL...hh....	0	8	8	8
+14878	PF15027	DUF4525		Domain of unknown function (DUF4525)	Eberhardt RY	re3	Jackhmmer:Q09328	Family	This domain is found in eukaryotes. It is often found at the N-terminus of glycosyltransferase family 18 enzymes (Pfam:PF15024). It is also found in coiled-coil domain-containing protein 126.	27.00	27.00	63.10	62.30	23.90	22.80	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.68	0.71	-4.64	7	96	2012-06-26 12:10:43	2012-06-26 13:10:43	1	3	41	0	56	75	0	130.60	64	31.53	NEW	shshshK..SQKLuhhLlsFGhIWGhMLLHaThQp.sp+pSSspLRpQILDLSKRYlKALAEEN+slMDGs.uuoMsuY.DLK+TlAVLLDsILQRLsKLEsKVD.llsNGousNhTNuTusshsslsssc+sssuuslp	...............hhhhshK..SQKLuhhLlsFGhIWGhMLLHaTlQQ.spppSSuhLREQILDLSKRYlKALAEEN+Nl.VDG....s.uusMsuY..DLK+TlAVLLDsILQRlsKLEu...KVD.lVlNGousNoTNuTo.slss.lss.c+lNsus.I........................	0	5	8	21
+14879	PF15028	PTCRA		Pre-T-cell antigen receptor	Bateman A	agb	Jackhmmer:Q6ISU1	Domain	The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation [1]. This protein contains an immunoglobulin domain [1].	27.00	27.00	31.40	67.40	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	154	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.07	0.71	-4.65	3	29	2012-10-03 02:52:13	2012-06-26 13:13:27	1	1	19	3	13	51	0	146.70	75	63.73	NEW	GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGLDSsIWFSAGNGSALDAFTYGPSPAsDGTWTSLAQLSLPSEELAAWEPLVCHTGPGAGGhSRSTQPLQLSG.EASTARTCPQEPLR...............GTpGQsLRLuVLRLLLFKLLLLDVLLTCSRLC	.........GVGuTPFPSLAPPITLLVDGKQQhLVVCLVLDVAPPGh-SPIWFSAGNGSuLDAFTYGPSPAsDGTWTuLAQLSLPSEELAuWEPLVCHTGPGAtG+SRSTQPLQLSG..EASoARTC.hEPLR.................Gh.utsLhLGsLRLLLFKLLLhDlLLTCS+L........	0	1	1	1
+14880	PF15029	DUF4526		Protein of unknown function (DUF4526)	Bateman A	agb	Jackhmmer:Q8WUU8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals and includes the human integral membrane protein TMEM174 protein.	27.00	27.00	175.40	175.30	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	232	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.81	0.70	-11.83	0.70	-4.78	5	34	2012-06-26 12:24:07	2012-06-26 13:24:07	1	1	32	0	23	31	0	233.20	66	96.34	NEW	-DFulNVFSVoPYPu.SpSDupVSDGDKAGATLLFSGIFLGLVGITFTVMGWIKscGpoHFEWTQLLGPILLSVGVTFlLISVCKF+ML.SCKPCKpoEEss...LDhEQoSuGQSFVFTGINQPITFHGATVVQYIPPPYuopDssGGso....PllSNsNulaSuau..sssusGPPQYYsIYPMDNPAFVpD-ssPupluts-....lcsSpPDAuhp-E-tLGsscosEhSPPuYEEIFPTsR	.EDFPlNVFSVTPYTP.STADIQVSDDDKAGATLLFSGIFLGLVGITFTVMGWIKYQGVSHFEWTQLLGPILLSVGVTFILIAVCKFKML.SCQhCKESEERl....Do.EQTsGGQSFVFTGINQPITFHGATVVQYIPPPYuSpEPhGhsosYLQsslsPCGLlsSGGA..sushPSPPQYYTIYP.DNuAFVsDE.shPuas.suus.....cRsssDAcpLE.EspL.t--.ssssFSPPPYEEIYuls.p..	0	1	2	7
+14881	PF15030	DUF4527		Protein of unknown function (DUF4527)	Bateman A	agb	Jackhmmer:Q6ZRC1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates.	27.00	27.00	33.40	33.40	26.90	23.80	hmmbuild  -o /dev/null HMM SEED	277	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.79	0.70	-5.09	5	28	2012-06-26 12:29:08	2012-06-26 13:29:08	1	2	22	0	14	26	0	239.40	52	67.78	NEW	QLRDsEA-soEEDLRLRVQQL+HQVLTLQCQLRDQsuAHRtLQAuh-EATsLQDcLQuKL-ELQKKQHEANLAVoPLKAKLASLVQKCRERN+LITHLLQELHRHGluNHLLSEhAQuMVsDVALAEYAATFLAPGlPETSHH..LDVESEcTAsc+A.QKYLLNPEtDSV..LQssLpSESWPlPEAEWPAQTApLDS.hKLPLPSGsTPsPGTC.AuVAVEPuLPAQsL+EcGGsSCPl.LpADsLPPPsELLSPARILAFHQELRQSICSNSQVNKSPLE	................................................pDsEApssEE-.RLcsppLHHpVLTLQCQLRDQuuAH...QAuh-E.As+LpccLpscL-ELQKKQHEApLAVTPLKAKl.ASLVpKCpERN+LITHLLQEL+RHGhsNhLLSElAQsMlsDVALAEYuATFLuPGlPETSHH..LDVcSEhTAshRA.QphLLNPchDSV..lQpshpSEShPlPcsEWPApsApL-S.lK.LPLs.ssT.DPGsC.AusssEsGLsAQpLQEcGGhsCPs..LpssslsssSELLSPARILAFHpELRQSICSNSQVpKSPLE...................................................	0	2	2	2
+14882	PF15031	DUF4528		Domain of unknown function (DUF4528)	Eberhardt RY	re3	Jackhmmer:A6NNL5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 95 and 154 amino acids in length. This family includes Human C15orf61.	27.00	27.00	38.50	38.50	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-10.83	0.71	-4.38	13	65	2012-06-26 12:31:18	2012-06-26 13:31:18	1	1	59	0	42	60	0	119.40	64	85.25	NEW	KPtASEVLTuaL+QRscPsWTSYFV+YpcVtNDQaGhSHFNWsV.sGsNYHILRTGCaPaIKYHCT+RPhQDLohEDpFFphlKllNLGlPsLhYGlAAhhLI+HpEhVcsuc..GsVsIYFLhcED+G	...............+PpASEVLTpaLhQRphP.WTSahV..YusVpNDQFGhSHFNWsV..pGuNYHlLRTGCFPFIKYHCSKtPhQDLuhpD+FFpsLKVlNLGIPsLhYGLuuhhhh+hTEhV+TSh..GPVTlYFL.KEDcG......	0	10	14	29
+14883	PF15032	DUF4529		Protein of unknown function (DUF4529)	Bateman A	agb	Jackhmmer:Q6P387	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.	27.00	27.00	43.80	43.00	19.70	19.40	hmmbuild  -o /dev/null HMM SEED	400	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.48	0.70	-5.87	5	37	2012-06-26 12:32:13	2012-06-26 13:32:13	1	1	27	0	20	36	0	334.60	49	98.13	NEW	MDL...CpKsET-LENuENsEI-SoEETELTYTCPDERSEKNHVCCLLslSDITLEQDcKApEFlIuTGWEEAVcGWGRTSPTACIWPRKKsKKARVGEuAs..SsCLLCssLSpGSLEuRP.opuuK......AEsGPEKDpGSsSQTpusPQGPosASRE.INKICFPTYhpGEKKSLQIKEFIWChEDWAoPETlRGKssRsPSpGscphLSISDuLTSRALLVLPPLKuSssNuLDVLGKKSKNhFLQPEEKVLuVEKDECVAhsYGLKoVDGKGEKpssELA+Hs+VsDhhPFPPsVApTsLL.A-sEpCCLHWSLLPEKNLlCPPsPoNl+YLATlQLLQKQGsQNYKA+hKA+EPRPPhpTpK+lLTEAKQENRPQMLETKVFPRPLLPSLTVSRVVIPVSTHRlL	....MDl...CQKsET-LE.tcssEIppsEETp..ohTCPDt+SE+sHVhCLLslSDlTLEpDp+A..pEFhIGTGWEEA....VpGWG+sSPsACIW.P.RKpsKKu+sGEus...SsCLlChsLsp.....ho...h..-s+P.hps...............sspcspuossphpusstu.tsuSRt..hsplshPs.hpuEKKSLQlKEFIWC.ccWshPpo.+s.Ks.ts...sstsspp.t.ohsssLoS+ALLVLPPLKuS..NsLDlluKKo+s.hhpsEEKshsVcK-tshuts.GhKos-GKGEKR..E.....LApH.hVsDh.s.PsssApTsLL.scsEpCCL+WSLLsEKshhsPPs...s...ssl+YLAsLQLLQKpGhQsaKs+h+A+-PRsPh.opK+hh.cAKQEsRPphLEoKVFs+PLLPSLTVsRVlIPh.sHRhL...........................................................................................................................	0	1	2	5
+14884	PF15033	Kinocilin		Kinocilin protein	Bateman A	agb	Jackhmmer:A6PVL3	Family	This family of kinocilin proteins is found in vertebrate. In mouse it has been shown that this protein is expressed primarily in the kinocilium of sensory cells in the inner ear [1].	27.00	27.00	34.50	34.30	22.90	19.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.60	0.71	-4.60	6	31	2012-06-26 12:53:32	2012-06-26 13:53:32	1	2	22	0	16	38	0	105.50	75	99.54	NEW	MDIPISoRDFRCLQLACVALGLVAGSIIIGVSVSKAAAAVGGIFlGAAGLGLLlhA.YPhLpu+FphshlhPsI.........GsLRIHPpsGPDHGEGRSSsNuNKEGARSuLSTVoRTLEKLKPGGRGTEEG	...MDIPIS.oRDFRCLQLACVALGLVAGSIIIGlSVSKAAAAhGGlFIGAAuLGlLlhA.YPFLKARFNLDHILPsl..........GsLRIHPpsGPDH.GEGRSSsNGNKEGARS....SLSTVoRTLEKLKPGs......RGsEEs....................	0	1	2	4
+14885	PF15034	KRTAP7		KRTAP type 7 family	Bateman A	agb	Jackhmmer:Q8IUC3	Family	This family of keratin associated proteins are found in vertebrate.	27.00	27.00	123.30	123.20	21.10	17.40	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.60	0.72	-10.17	0.72	-3.34	5	24	2012-06-26 13:00:44	2012-06-26 14:00:44	1	1	19	0	12	27	0	85.90	84	100.00	NEW	MTRFFCCGSYFPGYPCYGTNFHGTFRATPLNCVVPLGSPLNaGCGCNGYSSLGYuFGG.SNFsNhGCCYGGSFYRPWGSGSGFGYSTY	MTRFFCCGSYFPGYPsYGTNFHRTFRATPLNCVVPLGSPLNaGaGCNGYSSLGYuFGG.SNFsNLGCsYGGSFYRPWGSGSGFGYSTY...	0	1	1	2
+14886	PF15035	Rootletin		Ciliary rootlet component, centrosome cohesion	Coggill P	pcc	Jackhmmer:Q86T23	Family	\N	25.10	25.10	25.40	25.30	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.69	0.71	-11.00	0.71	-4.30	29	212	2012-06-26 13:02:07	2012-06-26 14:02:07	1	5	88	0	120	189	1	174.70	35	10.71	NEW	++Rl-AspEpQccpAsLhutLQpK.....ltpY..Rp+hu-lEppl....................ssp..........+.sccphshslcc................................hls+LEEEcpRs-p.......LR.ph-ptphpNppLps-lp+Lpppapt...plppKEchappcEcshspYlssEpp+.hhsLWp-lppVRRQhuEh+spTERDLpp.+sEas+ss+sl	...............................................++Lps.pEuQpcQApLVp+LQuK.....lhQY..+..p..hCt-LEppl............................................................................ttp...t....p..hpstpc...sL-p.......................................................................................................hLhRLEEEpQ..RspsLspVN..s.LRtph-puphsNcuLpcDlpKLTs-asphpcELtp+E.spap..pEpct.....ap.sYhp....sEHsR.LLtLWRpVVshRRph..tEh+ssT-.RDLtch+sEhsRhutp.............	1	24	33	72
+14887	PF15036	IL34		Interleukin 34	Bateman A	agb	Jackhmmer:Q6ZMJ4	Domain	\N	27.00	27.00	161.00	160.70	18.60	18.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-11.31	0.71	-4.70	5	39	2012-10-02 01:28:15	2012-06-26 14:07:47	1	1	27	13	17	42	0	160.20	69	72.21	NEW	GLElWslAus-ECulTGaLRDKLQY+NRLQYMKHYFPINYRVuVPYEGVLRsANITRL.....p+ApVSpRELRYLWVaVSLsATEpVpEVLLEGHPS.WKYLpEVcTLLccVcpuLu....pDVEls.P+VEulLoL...LopAsG.Sl.KLVRPKALLDNCaRVMchLassCC+pSSl	.........LEhWPLTQs-ECslTGaLRDKLQYRNRLQYM........KHYFPINY+ISVPYEGVhRlANlTRL.....QRAcVSERELRYLWVLVSLSATESVQ-VLLEGHPS.WKYLpEVpTLLLsVQpuLh.....DVEVu.P+VEuVLSL...Ls.APG.sL.KLVRPKALLDNCFRVMELLYCSCCKQSS.......	0	1	2	4
+14888	PF15037	IL17_R_N		Interleukin-17 receptor extracellular region	Eberhardt RY	re3	Jackhmmer:Q6ZVW7	Family	This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain [1]. Human putative interleukin-17 receptor E-like consists only of this domain.	27.00	27.00	28.40	28.00	24.50	23.80	hmmbuild  -o /dev/null HMM SEED	406	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.49	0.70	-12.55	0.70	-5.48	7	139	2012-06-26 13:28:15	2012-06-26 14:28:15	1	5	37	0	62	140	0	299.40	33	61.25	NEW	sluC.h....pT+C.Ls.Rhssphssputh...c...t.....cs.h..................pGlpsuhhphhV.tShpua.hthCthachsssAphplhup...Sptut+hsshpsslup+shhop+TQPs.scsh.......SQ+ptsP.................cauasl.s-scslpVTls...susEhslRLCapWslpCp-hupPhss.K.loGs+sVsLsYphLLPCLCIEu..Lp.DoVRpchCPFps.PcAahp-hWcuh+asshSt...hVhtLshhCPLKlcAoLC.Rps.to.CcsLssAhupEu...-thhlhptVDhHPpLChKFShtsuoalcCPapss..ohssWsssMshpspQhhLchSShstssFSuuhshPt.u.st.h.ss..hSpspsps.Pssh-LllshL+sGsCl.VWRsDV.FuhhtL.Cs	.............................................................................................................................pt...p.s.hph.s.........thChhhch.ssut.hh..up.....s.tshhhsshpsslupcshhhphTpPphtcth........s.ppthP.......................a.hsl.s-ucslpls...ls...su.-.phtLsh.W...psps.spPhhh.+.lousptlsLsap.LlPCLCIp.s.h...h.p.....DslR..pphCP..Fpp.....scAa........ps.............hWcsschp.ho.........shthps.Csl.s.csuLC.pts...ts...CpsLsssht..ps...pthh.h.hlchHPpLCh.phs..p..p.p..lppsh.ts....shs..shpssh.h.......p.tohh.ht.Ssshs....................o...s.s..h.hp..lh...t.t.C..h.................................................	0	3	6	22
+14889	PF15038	Jiraiya		Jiraiya	Eberhardt RY	re3	Jackhmmer:A6NGB7	Family	Jiraiya inhibits bone morphogenetic protein (BMP) signaling during embryogenesis [1]. The human member of this family is TMEM221.	27.00	27.00	33.30	28.20	22.70	22.60	hmmbuild  -o /dev/null HMM SEED	176	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.09	0.71	-4.85	11	78	2012-06-26 14:47:06	2012-06-26 15:47:06	1	3	63	0	58	82	0	135.70	31	46.85	NEW	LsuLuLLsllSllhAlLSLIhLL+lpssstpstt.hhtstt.th.ss.....-thhhlY-lohALsALuLoLNLsCLLVCAlQhhFAs+llRus.sssuRs.....spaLtcSpssRpsAluuFFluIsVaLoulhLYohlpFcspPuIsoShllGsGllF.......CsuuMlHslalWp+tcspuh+phshs	......................hhhhsl.uhlhuhluh.hlhphps..ht.....................t.h.hlh.lshsLsuLsLsLslsslllsslphhhsschh+s......tRs..................shaL.cs.ph.RhsAluhF.hhulsVaLsul.lYs.hl...Fc.psuhssu.llGsGhlh.......h.sssh.sHslhhht+tpp.uhpt...s.................	0	14	20	42
+14890	PF15039	DUF4530		Domain of unknown function (DUF4530)	Eberhardt RY	re3	Jackhmmer:A6NGS2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically around 140 amino acids in length. The human member of this family is C19orf69.	27.00	27.00	77.20	130.50	23.20	21.10	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.59	0.72	-4.16	4	23	2012-06-26 14:53:34	2012-06-26 15:53:34	1	1	18	0	9	24	0	111.20	69	85.98	NEW	MELW+QL+QAGLVPPGLGPPP+ALRtVPPVtpsGQTLhSsGADTGGAREpLLWIWEELGNLRRVDVQLLGQLCSLGLEMGsLREELVTlLEEEEEppppEEcp......tPEcKQE	..MELW+QL+QAGLlPPGLGPPPpALRtlPPs-pPGQTLhouGADsGGARESLLWIWEELGNLRRVDVQLLGQLCSLGLEMGALREELVTILEEEEEsscEE.EEs.....ppsppKQ-.............	0	1	1	1
+14891	PF15040	Humanin		Humanin family	Bateman A	agb	Jackhmmer:P0CJ71	Family	This family of proteins is found exclusively in humans. Humanin is a short anti-apoptotic peptide that interacts with Bax [4].	27.00	27.00	43.70	43.50	24.20	17.70	hmmbuild  -o /dev/null HMM SEED	24	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.62	0.72	-6.71	0.72	-4.70	9	21	2012-06-26 14:56:28	2012-06-26 15:56:28	1	1	4	2	11	26	0	24.00	75	97.68	NEW	MAsRGFSCLLLSTSEIDLsVKRRh	MAsRGFSCLLLssSEID.LssKRRh.	0	11	11	11
+14892	PF15041	DUF4531		Domain of unknown function (DUF4531)	Bateman A	agb	Jackhmmer:A6NCJ1	Family	This family of uncharacterised proteins is found in mammals. This family includes the human protein C19orf71.	27.00	27.00	85.80	85.80	18.10	17.50	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.23	0.71	-4.52	3	25	2012-06-26 14:58:44	2012-06-26 15:58:44	1	1	20	0	15	25	0	164.20	65	88.51	NEW	PcsLYSDDYLSLEGPRWsPAIRQAVRWKYTPMGRDAAGQLWYTGLTNSEoREAWYsLPRALDSPYREAYsRWHGCaQ+RERoMPSAYTQHLRETAWaDPlIPAQYpsPSTRWGSTLWKDRPIRGKEYVVNRNRYGVEsPWRuSDYVPhLSAPQRPRaTTQsYRQWGLEPYCPSTsQRPPPuaTP	....PsPLYSDDYLSLEGPRWsPAI+QATRWKYTPMGRDAAGQLWYTGLTNS-spEAWYsLPRA.sSPaREAYsRWHGCap+RE+ohPSAYTQ+LRETAWaDPllPA.QYhsPSTRWGShLWKDRPIRGKEaVlNRpRaGlEs.WpuSDYVP.LSsPQRP.hTsQsYRpWsLEPYCPSTsQts.P..TP.....................................	0	1	1	3
+14893	PF15042	LELP1		Late cornified envelope-like proline-rich protein 1	Bateman A	agb	Jackhmmer:Q5T871	Family	This family of uncharacterised proteins is found in mammals.	27.00	27.00	60.80	30.30	26.70	25.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-11.23	0.72	-11.72	0.72	-3.87	3	23	2012-06-26 15:02:28	2012-06-26 16:02:28	1	2	18	0	11	14	0	85.90	71	91.06	NEW	MSSDDKsKSuDPKNEPKNCDP+CEQKCETKCQPSCLKKLLQRCSEKCsh-KCPsPPKCsPCPPCPP.........SsPssPhCPP.CsPPCPuP...CPPSCPPKPCVKPCPPKCPS....PCPPPE	.MSSDDKsKSs-PK....sEPKNCDP+CEQKCEoKCQPSCLKKLLQRCSEKCPREKCPsPPKCPPCP.s..ss.........................Cs..Cs.....CP..CP........................	0	1	1	1
+14894	PF15043	CNRIP1		CB1 cannabinoid receptor-interacting protein 1	Eberhardt RY	re3	Jackhmmer:Q96F85	Family	This family of proteins interacts with cannabinoid receptor 1 (CNR1) and attenuates CNR1-mediated tonic inhibition of voltage-gated calcium channels [1].	27.00	27.00	28.40	30.10	25.70	17.20	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.93	0.71	-4.96	11	73	2012-06-26 15:23:00	2012-06-26 16:23:00	1	1	58	0	49	64	0	150.20	52	97.72	NEW	Mus....hstlh+lolSL+hpPssuPVFaKVD.GpRFuQs.RTIKLLTsSpY+l-VshKPush..pshulGGsslsLEp.po+..DtppsVYou.asT-GlssoKSG-RQPlplslpFsshGthcss.......hQsKaYshpcp-H....CpWGsshpsIEaEC+ssEsRolhhl.........pKEsF+	................Mu-lPsll+loluL+hpPN-GPVFaKVD.GpRFGQ...........s.RTIKLLTGSpYKlEVplKPsTlp..sp..sluIGGlhlPLE.+o+...DspplVYoGhYDTEGVssTKSG-RQPlQlsh.FschGsFETs.......WQVKaYNYcKR-H.......CQWGssFssIEYECKPNETRoLMWlNKEoF.h.............	0	10	14	33
+14895	PF15044	CLU_N		Mitochondrial function, CLU-N-term	Coggill P	pcc	Jackhmmer:Q96NS8	Family	CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organisms.  The function of this domain is not known. It family is found in association with Pfam:PF13236.	22.60	22.60	22.60	22.60	22.20	22.20	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.42	0.72	-3.82	51	327	2012-06-26 15:24:58	2012-06-26 16:24:58	1	45	226	0	243	326	1	76.20	35	5.87	NEW	lss..p-plp-l+phLhpt..sposhhTsapL.p..h..c..G.tp......l.scas-lspltsl.......ps....ss....p..Lpll..c-..sYsp.+pAchHlpRlR-ll	................................................ssp-pVp-l+QhLh-p.ssTsahTsFsLp.h..c..Gpp........L.ccasElpslpsl...................pt........ss....pLplV...........E-PY.Tt.+-ARhHVp+lR-Ll.........	0	60	122	197
+14896	PF15045	Clathrin_bdg		Clathrin-binding box of Aftiphilin, vesicle trafficking	Coggill P	pcc	Jackhmmer:Q96F83	Family	Aftiphilin forms a stable complex with p200 and gamma-synergin. This family contains a clathrin box, with two identified clathrin-binding motifs.  This family of proteins is found in eukaryotes.	22.50	22.50	22.50	25.00	22.10	20.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.01	0.72	-9.52	0.72	-4.47	36	120	2012-06-26 15:31:09	2012-06-26 16:31:09	1	2	65	0	69	134	0	73.40	46	10.68	NEW	EhhcVWspLQDlcsuauLRYQWuuSHSNKpLLsSLGIDoRNILFoGsKp.......pslhVPhaAAGLGM..LEPTKtslc.P	...t..hclWppLQDIcsApuL+YQWuuS+ss+pLLsSLGIDoRNIhhoGsKt.......pslhhPhaAAuLGh..LEPsKt.lp..s......................	0	12	17	38
+14897	PF15046	DUF4532		Protein of unknown function (DUF4532)	Bateman A	agb	Jackhmmer:A6NCN8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	52.20	37.60	22.60	19.00	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-11.77	0.70	-5.41	5	36	2012-06-26 16:18:15	2012-06-26 17:18:15	1	1	29	0	24	26	0	228.90	52	89.88	NEW	MVHApEoLPTsQTWAQREFLLPuEopEaPGFTpQAYHQLALKhPPCT-hKuKVRQRLhpPWKDAAQHTWGFHTWLDVGRLPATFPTRPDRPYDSNVWRWLTDScAHRpPPAEPPIPPPSWMGQNSFLTFIsCTPIFVDhNRKKQVIlRTVKELKEVEKLKLRSEARAPPLDAHGNILPPKNFKKYRHISAGGRaEPQGLQLMPNPLPNNFARSWPCPNPLPHYQEKlLKLALLPSAPLSQDLVRsYQTLIEsRVALPLHHLS+ApPGKTssRKhKRRPG	.................MhpApE...s.pTWsQR.EFhLPscohchPGFT.QuYHpLALK.PPsT-hKScVRpRLhpPWKsu..s...p..H.TWGFHTWLDVGRLPATFPoRPD+PYDSNVWRWLTcop....AH+pP..........P...........uc...P..I..PPPSWMGpNSFLoFIpstPlFl.DhpRKpQVIhRThKEL+E..lEKLKLRSEuRAPPLDupGNIlPPtsFKK...ahss..................................................................................................................................................................	0	5	6	9
+14898	PF15047	DUF4533		Protein of unknown function (DUF4533)	Bateman A	agb	Jackhmmer:A2RU48	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. This family includes two human proteins: C12orf60 and C12orf69.	27.00	27.00	52.20	52.10	25.70	25.50	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.43	0.70	-11.35	0.70	-4.93	4	54	2012-06-26 16:22:02	2012-06-26 17:22:02	1	1	28	0	35	55	0	208.40	41	92.27	NEW	c+pcLlpht+phF.pMpD.hphTNpLhElhNuphsspItpIpMKEDusVK-sh-.Ilphh+ElQstlpthpspMpcc........h.sohhcK.pslKEhpppthtlh+pVhosllspshsoush..lKhLpSSLohlhhs.lhsL............tp.uuol.tuhSsus.tlGhs.IL+tl.sAlcpsplpssl+Sht-pLtphhcs.c.hhchlpcshsTlc	.c+pcl.phtpphh.plpD.hssTNpLs-lhNtphssplh.lphKc-uoIK-sh-.l...lpshpchQptlpphc-slpcc............h.solhcKhpslKEhcppthslhppVhosllspAhsuush..lchltSslophhh..lhslh..............tp.u....so.htShus.us.thshc..hl+tl.sAlcppphpssI+ShtccL.phhpA.c.hhcslpcshpTlc.......	0	2	2	8
+14899	PF15048	OSTbeta		Organic solute transporter subunit beta protein	Bateman A	agb	Jackhmmer:Q86UW2	Family	\N	27.00	27.00	39.00	37.80	26.70	22.90	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.64	0.71	-4.05	9	37	2012-06-26 16:25:08	2012-06-26 17:25:08	1	3	31	0	24	34	0	122.30	45	82.98	NEW	-HSpssptAsssshVPQEL.......................LEEMLWaFRsEDAoPWNYSILsLusVVslISFlLLuRSIpANRNpKhp....ss-KppPEs.pLs-u.h+-sssLshLRET..LLSEKP...sLAQ.............sEhElcp+Dssh.shLsDP	.........................pt.pss.tsssussVPQEL.......................LEEMLWFFRsEDAoPWNaSILALusVVlhlShhLLuRuIpANRpcKhp........s.-KpsPEshphsEu.....t.h......+.-csuLss....LcET....LLSEKP...sLsp.............sphELK-+Ds...shhs-..........	0	1	1	6
+14900	PF15049	DUF4534		Protein of unknown function (DUF4534)	Bateman A	agb	Jackhmmer:Q8N7C4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in mammals. Proteins in this family are typically between 170 and 190 amino acids in length. The protein includes the human integral membrane TMEM217 protein.	27.00	27.00	73.40	73.10	19.20	19.10	hmmbuild  -o /dev/null HMM SEED	163	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-10.93	0.71	-4.61	10	43	2012-06-26 16:29:12	2012-06-26 17:29:12	1	1	23	0	28	31	0	158.00	42	85.33	NEW	u+MhSlLsGlFSllsTp.aLIFEhpalsphshp-phshYpsTpshltsallsaphsIshsLShlTIllSCFLLYslasphYhGLLhYslWIlhYEhlNhsl.lLTNs..cpphKElphL+Whh.lSRhlLHhFhL.FVlpHAYhlYKspppssllua+RRhSs	.A+hGolLuGlFoIhsTh.aLIFE.palsphssp.-p.hshhpsspshlssallsaphsIslhLShlTIllSCFLLYSVasplYpGLllYslWIlhYEhhNhsl.lLTNs..cpshcEl+hh+WhGhlSRhhhHhFhl.FVlpaAahlYKspppssllua+RR.Sh............	0	1	2	2
+14901	PF15050	SCIMP		SCIMP protein	Bateman A	agb	Jackhmmer:Q6UWF3	Family	This family contains the SCIMP proteins which are a a transmembrane adaptor protein involved in major histocompatibility complex class II signaling [1].	27.00	27.00	29.60	28.50	26.90	26.20	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.74	0.71	-4.26	4	30	2012-06-26 16:34:01	2012-06-26 17:34:01	1	3	24	0	16	30	0	121.40	61	67.48	NEW	MsWWRsNFWlILAVAIIsVSsGLGLILYCVCRh.LRQG+KWElAKPLcpcpRDEEKMYENVhNpssVQLPPLPPRuh..PEcouPQEsPSQPsAsYS.VNKV+NKKsVuIPSYlEPEsDYDDVEIPAshEpp+	.....MsWWRsNFWIILAVA.IIlVSluLGLILYCVCRhpLRQGKKWEIAKPLKpcQtDEEKMYE...NVlNpSPVQLPPLPPRsh.S.Ecs...SPQEsPS.tP.PATYSLVNKl+NKKsVSlPSYlEPEsDYDDVEIPANhEpt............................	0	1	1	2
+14902	PF15051	FAM198		FAM198 protein	Eberhardt RY	re3	Jackhmmer:Q9UFP1	Family	This family of proteins is found in eukaryotes. The function of this family is unknown. Murine FAM198B is downregulated by FGFR signalling [1].	25.00	25.00	27.50	26.70	24.10	23.30	hmmbuild  -o /dev/null HMM SEED	326	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.43	0.70	-12.23	0.70	-5.74	8	108	2012-06-27 07:44:34	2012-06-27 08:44:34	1	3	42	0	61	111	0	277.00	52	64.22	NEW	usIRlYutpuPPWFSc-DIpsMRhLADupVsuhs+.........lPu+uts.hllLc.......pussssuptCssp.CGlIKRPhDhoEVFAFHLDRVLGLNRoLPAVuR+Fco.......hssGpspPVlLWDPSlp...ssss-psShpLsWspYQphLKp+ChtsGpl.....PpsphsCosIHHpEWu+LALFDFLLQIa-RLDRsCCGF+PcspDsCVppGLHt+CcNpcclpLsHIlpR+pDP+HLVFIDNpGhFc+sEDNLNFRLLEGIcEFPEoAVSVLpS.u+LRp+LLQSLFlDQhYWESQGGRpGl-+LIDVIE+RAKlLLpYIptHsl+llsMN	.....................................................................................................................utpsPsWhoccDlpth+LLAputVssht..........ls..u+utsh..lshp..............ts....s.s..hs.hCu.u.CGLlKpPhDhsEVhAFHLDRlLGLNRoLPuVuR+hc..............hpDGpspPlIh..Wss...slp...sss...spsp...sSltLsWhpYQpLL+p+Ch..sGps........sp.sCstIHHpEWu+hALFDFLLQlasRLDp.CCGFcP...c.pDsCVpptL+.KCcs.s.pltLsHIl.RppDPpHLVaIDNtGhhp+sEDpLNF+LLEGIcpFP-SAVpVLpS.tpLpphLLpSLhhDpVaWESQGGtpGlcpllcslEpRuplLlpaIptHshplh.................	0	8	13	29
+14903	PF15052	TMEM169		TMEM169 protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q96HH4	Family	This domain is thought to be structured transmembrane helices and includes the intermediary cytoplasmic domain. It is found in eukaryotes, and is approximately 130 amino acids in length.	27.00	27.00	98.30	97.90	25.10	25.10	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.81	0.71	-4.25	9	66	2012-06-27 09:45:27	2012-06-27 10:45:27	1	1	59	0	48	53	0	133.10	58	41.06	NEW	pt+psCphGlspG.HllLWSllClPlVFllSFlhSFYYGTlTWYNlFLhYNEERTFhHKIolCPhLIlhYPllIhssoluLGlYuAlsQlSWtaspWhpslpDhEKGFhGWlCuKLsL-DCSPYslVELhDs-s	....p..ppsCpsGscpGPHllLWoLlCLPlVFllSFlsSFYYGTlTWYNlFLVYNEERTFaHKIohCPhLILFYPlLIhshuhuLGLYuAVsQLSWuauuWWpuspDhEKGFhGWLCSKLGLEDCSPYolVELL-SDs...	0	9	14	28
+14904	PF15053	Njmu-R1		Mjmu-R1-like protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9HAS0	Family	This protein family is thought to have a role in spermatogenesis. This family of proteins is found in eukaryotes. In humans, it is found in chromosome 17 open reading frame 75 (C17orf75). Proteins in this family are typically between 217 and 399 amino acids in length.	27.00	27.00	50.10	33.60	20.50	19.70	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.26	0.70	-5.70	4	77	2012-06-27 09:53:00	2012-06-27 10:53:00	1	2	48	0	46	60	0	278.80	51	84.02	NEW	asLYuYRuuRhoQptuDo-DGpsuGsss-oPSG-DFSLSLVDTNLPuEsEsELRSFIAKRLSKGAVFEGhGNVASVELpIPtY+VGCYYCLFQQEK.LPEsAshESEpNssEYVVCFLGGSEKGL-..LFRLELDKYhQuLKsshssEp+sLEsclpsYLsSWFEssVCPIQRVVhLFQEKLAFLLHAALSYTPVEVKpuDE+Tc+DINRFLulASLQGLlpEGTMTSLChAMTEEQH+SlIlDCSGsQPQhHNAGSNRFCEDWMpAFlNGAEuGNPFLFRQlLENFKLKAIQDhNNLKRFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHtEMPEA+sVVsVLEEFM+Eu	.......................................t.......t.t...stss........tth......t.ss.....stpDF.S...LoLhDosLPuEsEPELRoaIuKRLSK.GAlatGhGNVAoVELpIPt.t.VGCYhCLhpp..E+..sE.t.....ssh-u..p......t.....ss-YVlCF....LGGS..EKGLc.......hF+.L...ELDKYlQGL+ssh....s.sEp.p..sL-scl..+.sYLspW.aE-sVt.IpRVV.LhQcplsFL.LHAALSaT.VEVp..poD..-+TKpD....lpRFlpsASLQGL...p...ps...........T.h....s.SLCh..AhoE-p+psl..llDC.S..ss.Pphh..N.A.s..........S..N+FC-DWhpsa.Ls..us-tuNPFLhRQlLENFKL.KAIQDhNsLKRFIRQAEhsHYALF+CahFLpsCGsGDlLLp.hs+sEH..p..-hPEApsllsVLEEFhpE...............................	0	16	19	28
+14905	PF15054	DUF4535		Domain of unknown function (DUF4535)	Coggill P, Hetherington K	kh6	Jackhmmer:E0CX11	Family	This family includes the uncharacterised protein C7orf73 that is found in eukaryotes. Members are generally less than 100 residues in length. Although the precise function of the domain is still unknown, members have a predicted N-terminal signal peptide sequence which suggests they are short secreted peptides.	28.30	28.30	28.30	29.00	25.40	27.80	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.32	0.72	-4.55	29	115	2012-06-27 09:58:10	2012-06-27 10:58:10	1	2	61	0	77	131	0	45.20	40	60.68	NEW	+ushoFhhGsssGlYlAQNYpVPNl...pKLhpshh.hAKclE-pY+...KP	.........shhsFhsGsssGlYlAQNYpVPNl...pKLhpph..htKcl--ph+K...........	0	16	35	54
+14906	PF15055	DUF4536		Domain of unknown function (DUF4536)	Coggill P, Hetherington K	kh6	Jackhmmer:Q96GE9	Domain	This domain family is thought to be a transmembrane helix. It is found in eukaryotes, and is approximately 50 amino acids in length. In humans, it is located in the chromosomal position, C9orf123.	27.00	27.00	27.50	27.30	25.50	25.90	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.79	0.72	-8.28	0.72	-3.89	11	53	2012-06-27 10:01:04	2012-06-27 11:01:04	1	1	48	0	35	58	0	46.50	40	47.33	NEW	-ChuCRllSGsGLIGuGsYVahpA++R.p.stphuhholsphssulG	.sChuCRllSGhGLlGuGuYVahtA++..h.K.shs.u.tolsphshulu...........	0	5	11	20
+14907	PF15056	NRN1		Neuritin protein family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9NPD7	Domain	The domain family Neuritin1 (NRN1) is a GPI-anchored protein expressed in post-mitotic-differentiating neurons in the developing nervous system [1]. NRN1 is a glutamate and neurotrophin receptor target encoding a neuronal protein that functions extracellularly to modulate neurite outgrowth (OMIM:607409).\	\	  This family of proteins is found in eukaryotes. Proteins in this family are typically between and 158 amino acids in length.	27.00	27.00	29.80	29.20	25.40	22.80	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.22	0.72	-4.03	10	92	2012-06-27 10:04:05	2012-06-27 11:04:05	1	2	40	0	51	83	0	84.20	50	38.75	NEW	C-ulaKGFSDCLLpLGDsMuNYsQcl--cpslpoICoaWDDFHsCAsTALuDCQEsAu-lWEpLRpES+plsFQGSLFELCuuuouAssu	.......CDslaKGFu-CLlcLGDuMus.sp..t.......p.sppplcTlCp...W-DFHuCssoALssC..EtAsslWEpL+pES+phshpGsLa-LCuusst...ss...........	0	2	9	25
+14908	PF15057	DUF4537		Domain of unknown function (DUF4537)	Hetherington K	kh6	Jackhmmer:Q9NQ32	Domain	The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.	27.00	27.00	27.00	27.10	26.80	26.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.61	0.71	-4.34	24	111	2012-10-02 16:56:36	2012-06-27 11:18:52	1	15	44	0	74	124	2	127.80	31	19.59	NEW	sppVlARps...pDGaYYhGsVppph...ssstalV-a...........spptptltppclIths.ssh.ppsLpsGDtVLAh......hsstp.p..........YsPGhVh.............sspscplsVpFasGp.....psp..lPpppshhl.sp.shacpssthl	...............sppVlARp-...p-Ga.Y.a.G...plKpss....spsphLVcF.....................tttpppsVstppll.hu.suh..s.sLpsGDhVlAh......hpspthp..............YsPuhVlhh.ptp..........ssp-c.hTVhhhNs+........pth..lPtsslhhl.s...shathusph...................................	0	38	40	47
+14909	PF15058	Speriolin_N		Speriolin N terminus	Eberhardt RY	re3	Jackhmmer:Q76KD6	Family	This family represents the N-terminus of the sperm centrosome protein speriolin [1-2].	27.00	27.00	37.40	31.70	22.40	22.10	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.29	0.71	-4.41	7	60	2012-06-27 10:18:56	2012-06-27 11:18:56	1	4	26	0	35	66	0	166.50	43	42.05	NEW	Moh.ssaEGhpHphcRLV................pENp-LKK.VRLl+ENpcLKpA................LuEusts.stRtspsVhhP.uPAsApEss...psGhhshuPhAsh.soPp......Sst.tslhs.hTuoLssLLsu.ushSpps..ss.h............................os.h........ssuPGt.hAoSLulPppu.Lossu.........................shsuplAVShuSPLLoSTss..thsQphLtsP....................lushsLsEsPR	............G.pc.hpRLh................pENt-LKK.VRLl+ENp.L+ph................Lu-usttsss+.....t....slhhP..uPAhs..........Ess...tsGl.shu.hssh.sosp.................TusLpsLLsu.uP.hSpps.....................................................sssPu...hAoShtlP.pu.LoPsp.................hsspsssph.SPLLSs...........Ltss....................hsshsL.E.PR...................................................................................................................	0	3	3	7
+14910	PF15059	Speriolin_C		Speriolin C-terminus	Eberhardt RY	re3	Jackhmmer:Q76KD6	Family	This family represents the C-terminus of the sperm centrosome protein speriolin [1-2].	27.00	27.00	32.70	31.80	23.50	18.80	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.78	0.71	-4.18	4	66	2012-06-27 10:19:36	2012-06-27 11:19:36	1	4	32	0	39	68	0	137.60	60	35.82	NEW	lVGEIAFQLDRRILuhlFPt.hsRLYGFTVS.NIPEKIhQsSlps.saplDEchspsLTpRYVolhs+LppLGYNtcVHPshoE.LlNtYGILRpRP-LtAS.spS..sshLp+lLl-sV.PphLsDuLLLLSCLspLS+DDuKPhFhW	.........................lVGEIAFQLDRRILu.lFPt.hsRLYGFTVS.NIPEKIhQsSlps.DtplDEchhppLTQRYlolhsRLpp.LGYstcVHPu.hoE.LlNsYGIL+pRP..-LtAs.hto...sshLp+lll-sV.PphLsDuLLLLsCLspLu+-DuKPhFhW.................................	0	5	7	14
+14911	PF15060	PPDFL		Differentiation and proliferation regulator	Coggill P, Hetherington K	kh6	Jackhmmer:Q8WWR9	Family	Pancreatic progenitor cell differentiation and proliferation factor-like protein (PPDFL) is alternatively named Exocrine differentiation and proliferation factor-like protein. PPDFL regulates exocrine cell fate. This protein is highly expressed in exocrine progenitor cells which eventually differentiate to form exocrine pancreatic cells [1].	27.00	27.00	29.20	29.00	24.60	23.50	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.98	0.72	-10.51	0.72	-4.06	7	87	2012-06-27 10:23:41	2012-06-27 11:23:41	1	2	40	0	40	71	0	95.70	50	94.60	NEW	MAAIPSSGSLVATHDYYRRRLGSTSSNSSCGSuEYsGEsIPHpPGLPKuDsGHWWASFFF.GKSThPhMusVlESsEpp.tohpsSsu.lsCsLApcsh......ppQ.uupsuKossu	....................MAAIPSuGSLlATp-YYRR.R.lGSoSS.sSS...CuS.sE.asGEsIPHp....PGLPKsDsG+WW.uSFFF.uKps.Phhssl.Epspp......tssts.h.s..h...s.........p............s........................	0	2	5	17
+14912	PF15061	DUF4538		Domain of unknown function (DUF4538)	Coggill P, Hetherington K	kh6	Jackhmmer:Q8N5G0	Family	This protein family is thought to be a transmembrane helix. Its function remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are typically between 58 and 87 amino acids in length.	27.00	27.00	33.60	33.60	25.60	24.80	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.19	0.72	-8.80	0.72	-4.66	13	61	2012-06-27 10:24:17	2012-06-27 11:24:17	1	2	50	0	36	71	0	56.10	51	54.00	NEW	hhRGh+hslhlGGlVuhlGhAhYPIhlcPhhpsEEYK..clQplNRsGIcQE-lQPssh+	.................huRshRouLIFGGFlullGAAhYPIaFRPLh+hEEYK..+pQtlNRAGIhQE-lQPsGlK.........	0	9	12	22
+14913	PF15062	ARL6IP6		Haemopoietic lineage transmembrane helix	Coggill P, Hetherington K	kh6	Jackhmmer:Q8N6S5	Family	ADP-ribosylation factor-like protein 6-interacting protein 6 (ARP6) is a transmembrane helix present in the J2E erythro-leukaemic cell line, but not its myeloid variants. In tissues, ARL-6 mRNA was most abundant in brain and kidney. While ARL-6 protein was predominantly cytosolic, it is known to bind to SEC61-beta subunit of a protein conducting channel SEC61p [1].	27.00	27.00	27.70	29.50	22.30	26.80	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.01	0.72	-4.08	11	55	2012-06-27 10:28:35	2012-06-27 11:28:35	1	2	49	0	35	58	0	75.40	48	36.26	NEW	Qplps.VQuphshsh.WS.......+L.PLLsGLllsuFuYslVYLDSs.PGlhPPoPFSPps+pRhp..pupShHLuYhsAlhsG	...........................plpppstschshhsFWoh.......LllSLhuGh.CCSFSWTlTYaDSaEPGhaPPTPLSPu+hK+hs.....spSaHhGY.hAlLsG........	0	6	9	19
+14914	PF15063	TC1		Thyroid cancer protein 1	Hetherington K	kh6	Jackhmmer:Q9NR00	Family	Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma [1]. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle [2]. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor [3]. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.	27.00	27.00	28.80	56.20	23.20	17.50	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.92	0.72	-9.71	0.72	-4.44	9	80	2012-06-27 10:42:52	2012-06-27 11:42:52	1	1	39	0	49	70	0	77.50	54	59.15	NEW	tot.hh.SsSlRVuPSspG.+FD..TAsRK+AsANIFcsVsp-sLQ+LFc+oGDpKAEERA+lIashspDsEEhA+ALhAL+	.............s.....h.ssSlhsuPSsh..hpt.s........stuRKpAsANIFpss-..plQpLFpp....SGDppAEERA+IIaphstDhc.hAcALhtL+............	0	2	5	18
+14915	PF15064	CATSPERG		Cation channel sperm-associated protein subunit gamma	Coggill P	pcc	Jackhmmer:Q6ZRH7	Family	This family represents the gamma subunit of the CATSPER, or cation channel sperm-associated protein complex. The complex appears only to be expressed in the flagellum of sperm. The complex is activated at alkaline intracellular pH, and being restricted to the flagellum is the mediating calcium channel.	27.00	27.00	73.00	28.20	25.30	24.80	hmmbuild  -o /dev/null HMM SEED	825	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.26	0.70	-13.36	0.70	-6.81	4	89	2012-06-27 14:03:08	2012-06-27 15:03:08	1	3	30	0	42	80	0	504.50	38	85.95	NEW	Mhp.s....s...........shhlhhhVLLlsh+shutpshpcCoWhVslscap+lucphs.pp.....PlssV.p.hth..ssS.lpsoc.Y.uFPYaL+IphsCssKsSc-luRhhtLpGlpPhV+lhhp....ssssahphphE............................plph.h-sAsh+Ss.s....sC.s-hhCp.uWhsPhPhcsGoll.pV-lhssGlGsaI.ppR.hlphsGFhp.pstssssthultp-..l.t.thapshpuhPl....shuPVhILGGhsspchlLaosopFpcasllphpIsSphsuShhCshhuhssTIassluh.uoLhIppsphVh.asGsaosLh-+spuS....Rhh.scCI++Lpss..susGp..lLAlsst.pcGhlalGslpDu.hph..hsc.................taSsCphlsu.......uph.ssptTlLLLVths.hptotpaallpa..ssupcshElLYpIP-hIPpt+ph-aLhhLsocoass.......shhhscs.FhsslsshlalWGNhlL.p.............................................................................................................................ppss.h.loh.p.CPaphhph.plPp.Q+.oc.cpa.hhPshl..p.shHssNoLAlYpGLVaYhhah+s..-hs.h-shp.sshp.atp.ht....DpDYaFahhSNp...tslalsMsuYp+lashpushpl.Pp+hFLDpGspasaslhh.hasso.+sppp...thp..pplsLSlslu-PsslsVosppEhLlppsolLhpIsltDp+hsh-QshsGc+lptsSh.hpslsssGhphthTahhsHhp..t.h.hsVhIssPsGhRhth.lohoLpasht.spahhDpl.hstE.ssFhaRD.........D.shssSt.uhpGSash.VVsssshlpohpshh-pEI.Rhpushcp	..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	9	10	15
+14916	PF15065	NCU-G1		Lysosomal transcription factor, NCU-G1	Coggill P	pcc	Jackhmmer:Q8WWB7	Family	NCU-G1 is a set of highly conserved nuclear proteins rich in proline with a molecular weight of approximately 44 kDa. Especially high levels are detected in human prostate, liver and kidney. NCU-G1 is a dual-function family capable of functioning as a transcription factor as well as a nuclear receptor co-activator by stimulating the transcriptional activity of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) [1].	27.00	27.00	30.60	28.30	23.90	23.20	hmmbuild  -o /dev/null HMM SEED	350	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.10	0.70	-5.76	20	84	2012-06-27 14:54:08	2012-06-27 15:54:08	1	2	63	0	54	97	0	305.00	35	82.60	NEW	ssLlHlcA...sGsscTlHYlWss.hGsPolLlsh...Tsssso...lplsWschLssp.....hsuulphssps..pYotullhs+lhEFsDsNDouhhs..sssp.h.sYsLppFsWsphshs....sstslssshsut.hpp.......sGolshplsAFsspsRssphP+LLHouNSoQl-lslsslss+uspS...RFAlE............llsVssstsssssp...............p+SIDDEYTPuIFclsplhs.....hstsssssGalQW+PVuYspspRshssu..s.spps.......phpslps.....sshssoslshAaaGsp....h.hpuhNlSFGhssDG.FYpsosYhoWThllGhGpPPs-phSshVlhlhulGLGlPhlhllhGGlalsl++t+tpp	.....................sLlHlRA...sGsssTlHYlWss...hG..sPullllt.....Tssspo...lslsWsphlusp..................sssulhl.sps.l...paStAllFs+lhEasssssoshhs.........sp......hssYsLtpFsWsphs.s.....hs.tslssshp..Gpshpps.............sGSlshclpuFspssRssp..P+LLH.Tus.osQl-lsLsshss+....u..spS...hFuLE............lh.slupsssssphp...............pcSIDDEasPulFplspl.......................huo.ssGahQW+PVuasp.tp.tshpsu....hsspts.......shpss.s.........hshspsslhpAaaGsp.....................thpshNloFGsssss.hYhsppYloWohllGhG.PPsDthSsLVlslhuluLGsPhlhllhGGlhlhlt++p...p.................	0	19	23	36
+14917	PF15066	CAGE1		Cancer-associated gene protein 1 family	Coggill P	pcc	Jackhmmer:Q8TC20	Family	CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues [1].  CAGE-1 is predominantly expressed during post-meiotic stages. It localises to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa [2].	27.00	27.00	68.40	68.40	21.50	20.90	hmmbuild  -o /dev/null HMM SEED	527	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.66	0.70	-6.06	4	63	2012-06-27 15:13:07	2012-06-27 16:13:07	1	3	26	0	23	63	0	325.00	48	63.21	NEW	hSEu-oMNhsuhSQDloaScSPhhMEToSTTSDLPQsEhKNscRENESc.TLsEDIYGTlDshLsDhsItN.ucNlLTQPVDT.SlSShRQFEPICKFHhhEAFNDE.hshpsLptuhsYTEKPEhQSpVYNsAKDsshKpDSFKEENsVET..SsSsscDQLupEhVRQ.ssRSPPLlHsSGET.KFsEsShsKSsuhEuALpPSQPQSFLhhENsppsscps..ptNsFp.LDLRA.YptEEhsVSSKtlQshG-IPEhsVsapKEVshEGV-SPtIsSPWSPAGIsWpGuAs.-suhMPDhEQShES.QPlEEDMAL.ElLtKLcHTN+KQpspIQDLQsSNhYLE++VcELQhpsTKQQVFVDIINKLKsplEELIEDKY+lhLEKsDTsKTLQNLpElLsHTQKHLQEu+N-KEoLQLplKKIKuNYV+LQERYMTEhQQKs+oVSQCLEM-+TLScKEEEVcRLQQLKGELEKAToSALDLLKREKcTpEQEFLSLQEEFQK+-KENLEERQKLKSRLEKLLAQVp	...................................................................................................................................................tpPt..s.hht..tcs..p.t...Eps.h....sh..pp-.hs.t.h.p..spS....h.p..tc.....h.E.sh.ts...tssht..ps.sh....................................hsspthp...-hschsss.tc..-st.-shpp..thhSshssssl.hpsts..-ss.h.DhE.shEuLpPl.p.ED.hALNEsLp+LppsN+cQphpIQ-LptpNhhLEp+lcELQhphs+QpVhlDlIsKLKtplEcLI--KYplhLEKN-hp+pLpslpEh.spop+pLpES+p-KchLpLphKKhKspYhpLQERYhsEhppKscs.ophlEhp+sLSpK-EElpRLQph+t-hE...+sT.SALshLpcEKc.pEpEhLuhp.EFQ+h-+tpLpERpcLK.plpcLlsQl.........	0	2	3	5
+14918	PF15067	FAM124		FAM124 family	Coggill P, Hetherington K	kh6	Jackhmmer:Q9H5Z6	Family	The exact function of this protein family remains unknown. This family of proteins is found in eukaryotes. Proteins in this family are approximately 480 amino acids in length. There is a conserved LFL sequence motif.	23.50	23.50	23.60	41.90	21.60	23.00	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.73	0.70	-11.51	0.70	-4.93	13	111	2012-06-27 15:31:04	2012-06-27 16:31:04	1	4	44	0	66	93	0	222.70	50	52.79	NEW	lolHlls-sG-uphLQpAlDpLLsaIcPDlpLFpVS.ERtssh+tpcstptp..........tsphPuLuVlLFLpEs.hG..EEplhplpctLppPPW..paHHTppspG+..h............PahsssQDFaoLusthPlWAlRpVHYGpEIlRhTlYCsa-NYsDhl+hYElIL++csst+KsDFChFslYos.sh-lQlSLKpL.PhGhsPpPp-SulLpFRV+-lGQLVPLLPsPCoPIScsRWQTpDaDGNKILLQ	.....................holHllAssGcuphLQpslDplLshIpP-lpLFpVS.ERtush+hpct.ps..............st.PuluVlLFLp..Ep.hG..EE.....plhplpcsLQ+PPW..paHHTppspG.R..hh..................PYhsssQ-FaoLss..thPlWulR.VHaGpEIlRhTlYCpa-NYtDslRhYEhILpRps...otpKssFChFslaSsh..shslQhSLKpL.Phu.sssPp-SSVLpF+Vc-IGpLVPLLPNPC..sPISpsR.WQTpDaDGNKILLQ............	0	12	16	34
+14919	PF15068	FAM101		FAM101 family	Hetherington K	kh6	Jackhmmer:Q8N5W9	Family	This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilise peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes [1].	27.00	27.00	32.50	29.40	20.30	18.90	hmmbuild  -o /dev/null HMM SEED	207	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.45	0.70	-4.88	12	102	2012-06-27 15:39:28	2012-06-27 16:39:28	1	2	41	0	55	78	0	169.70	52	92.01	NEW	MVG+LpLQsh..s-sLctpsR.-GlLDSPDSGLPspPSPS..aasLusGhh........ssh......p.ptspput..s.PhhL.ss.uspspPRhpPl.FGEuIElcPhPs+EIRhsSpVKYDSE+HFhDcVhhhPls.slouhSpTllulPNCTWRsYKoplphEPRp+shRFpSTTIlaPKHs+ohYpTTLsYss...tpstRhFhSSVpLEssE	.....................................................................................ss...........................................s.....h..ss...ssthpPRh..hPl.FGEulEhsP..PspEl.R..hsSpVKYDSE+.HFhDcV.hhPls.sVsuhSpTllssPNC...TWRsY+uplphEPRp+shRFpSTTIlaPK+s+ssYpTTLsYss...t+s.hRhFhSSVpLEhsp...........................	0	4	7	22
+14920	PF15069	FAM163		FAM163 family	Coggill P, Hetherington K	kh6	Jackhmmer:Q96GL9	Family	This protein family is alternatively named Neuroblastoma-derived secretory proteins. Highly expressed in neuroblastoma compared to other tissues, suggesting that it may be used as a marker for metastasis in bone marrow [1].	27.10	27.10	27.20	27.10	26.90	27.00	hmmbuild  -o /dev/null HMM SEED	143	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.33	0.71	-3.61	13	90	2012-06-27 15:45:19	2012-06-27 16:45:19	1	2	40	0	58	70	0	148.20	51	97.46	NEW	MTAGTVVI....................TGGILATVILLCIIAVLCYCRLQYa...CC++p.......-s-p-.....ccp.shshpsh.s...................su.shhs....s.sppptpsp.hCsoC..o.at.s.Falpss............GGcRlsatshp.......................h...h.thhp.spuIST-V	............MTAGTVVI....................TGGILATVILLCIIAVLCYCR...LQYY........CCKKs.......coE--......EEE.Dhs...scs+hPshpusps.sh........sstsuLhPhtspshuppsstupshCsoC..S.YpsP.Falpps-............stNGGERlsatshp.c-ht.Ps...................hthus.Quhsssh.uuhREuFopsRuISTDV.......................................	0	5	10	22
+14921	PF15070	GOLGA2L5		Putative golgin subfamily A member 2-like protein 5	Hetherington K	kh6	Jackhmmer:A8MS94	Family	The function of the GOLGA2L5 protein family remains unknown. This family of proteins is thought to be found in the Golgi apparatus of eukaryotes. Proteins in this family are typically between and 840 amino acids in length.	27.00	27.00	27.20	27.20	26.20	26.70	hmmbuild  -o /dev/null HMM SEED	617	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.33	0.70	-13.17	0.70	-6.03	8	690	2012-06-27 15:46:46	2012-06-27 16:46:46	1	6	83	0	210	470	0	199.30	19	59.74	NEW	QLpESl+QLQsERDQYAEsLKEEuAlWQQRhQQMSEQl+pL+EEKE+uhuQVQELEoslAEL+NQhsVPP...sPpPPA...GPSEsE.ppLQuEsEQLQKELEsLutQlQAQV+DNEsLSRLNQEQEpRLLELERsAEpWuEQAE-R+QILESMQSDRsTISRALSQNRELKEQLAELQNGFVKLTNENMElTSALQSEQHVKKELAKKLGQLQEpLGELKETVELKSQEAQuLQpQRDQYLuHLQQYsAAY.......QQLuuEKEhLHKQhLLQTQLMDRLQHEEVQGKsuAEhApQELQEoQERLEAssQcNQQLQAQLSLhAsPG........EGDGLDSE-c-E.........EsspPpluIPE-LESREAMVAFFNSAlApAEEEpARLRpQLKEQKhRCpcLuHLlAssppp.ccc.AsuP..........tsuGD.SVPsEoHpALQVAMEKLQuRFTELMQEKsDLKERVEELEHRCIQLSGETDTIGEYIALYQsQRAVLKpRH+EKEEYISRLAQDKEEMKlKLLELQ-LVLRLVsERNEWpuKaLAAAQNPus.sosussA......QELGAA-sQGsLcEVSLAp.ss.........ltPsQGEA..Gsss......PpENPTAQQIMQLL+EIQNPQERPG..LGpNPCIPFFYRADENDEVKIMVl	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	122	129	171
+14922	PF15071	TMEM220		Transmembrane family 220, helix	Coggill P, Hetherington K	kh6	Jackhmmer:Q6QAJ8	Family	Transmembrane 220 (TMEM220) is a domain of unknown function. It is thought to be a transmembrane helix. The length of this protein is typically between 150 and 160 amino acids. In humans, it is found in the chromosomal position 17p13.1.	27.00	27.00	29.30	28.40	24.30	24.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.53	0.72	-3.58	29	81	2012-06-27 16:25:50	2012-06-27 17:25:50	1	1	72	0	51	95	19	97.70	30	68.70	NEW	hFshsAhlQlNDP...........DshlWlslY.....hlsull...shhhhhthhsphlhhhhss............shhhhhhhhtsslhttht.t.th............phE.uREhhGLhlsshhhhlhhhhs	.........hFshhAhlQhNDP...........Ds.lWhslY.....hlsAll....hl..hhs.tlssp.hlathlushah........hhshhhshhlsshlhtcsppshh.......................ppEcuREhhGLlIlsshhhlpt...p...........	0	17	29	34
+14923	PF15072	DUF4539		Domain of unknown function (DUF4539)	Coggill P	pcc	Jackhmmer:Q8N3J3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 230 and 625 amino acids in length.	27.00	27.00	27.70	42.00	26.70	26.40	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.25	0.72	-9.70	0.72	-4.29	32	116	2012-06-27 16:39:42	2012-06-27 17:39:42	1	2	98	0	75	119	2	86.40	37	17.40	NEW	stKVsplssll+slst..........sst.Ds.hlhlpD..PTGphpuslH.+clh.p..p..asstlssGusLlL+cVs.Vas...........ss......tptta.LslThpNllplass-s	..p.sKVsphsshl+Slst..........ssh.Ds.tllhKD..PT.G.phpuolH.+pllp..p...htspLpsGuVLlL+pVu.VFs..................PS......hpspYLNlT.pNLlplass-.s.........	0	27	38	56
+14924	PF15073	DUF4540		Domain of unknown function (DUF4540)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A4D263	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 302 amino acids in length. In humans, it is found in the chromosomal position, C7orf72.	27.00	27.00	28.30	28.10	21.20	17.50	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.94	0.71	-10.81	0.71	-3.60	6	31	2012-06-28 09:34:24	2012-06-28 10:34:24	1	3	28	0	21	43	0	119.80	47	33.03	NEW	PsKPlsFVSsSoRSKYIPLYTG+VQSTsADDlDNPhGDIsSlApPRsSchhYTNoSRoAsIPGYTGKsHasAT+PsNschPSpoPSsD.SEhHRlhh+cMtV.....DhFtHQuPLS+MVTTVpPYNPFNKKDKET	.............................s+PlsFVSsSoRSpaIPhY..oG+V.pSssu.DDlDNPhGDhtulupsRpS+.h....Y.Tsoo+usNIPGYTGKV..HFsATHPAN.SsIPsT.sPSsD....SEh+RslhcEMtV.......DhFRHQuPLS+hVTTV+PYNPFNKK-KET.............	0	11	11	11
+14925	PF15074	DUF4541		Domain of unknown function (DUF4541)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A4QMS7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 100 and 163 amino acids in length. There is a conserved KLHRDDR sequence motif. There is a single completely conserved residue Y that may be functionally important. In humans, the gene is found in the chromosomal location, C5orf49.	25.00	25.00	26.40	25.10	24.30	22.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.01	0.72	-3.44	12	46	2012-06-28 09:38:35	2012-06-28 10:38:35	1	1	39	0	33	52	0	87.70	51	61.98	NEW	YFssspppsphoh....YDplFph.ppsa...ssKLHRDDRp+hpslGLclppEEpp+sVPlLsSS.YG+.h..cpPl-..s+.casRls+Vps-FYp+ssI	.......Ya.p.tpsGllSL....YDslF++.c.sY...sQKLHRDDREHAKolGL+VNEEEppRsVsVLoSSVYG+Rl..ppPlEPhsR.casRssHVpsDFYRKNsI........	0	16	19	22
+14926	PF15075	DUF4542		Domain of unknown function (DUF4542)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A8MV24	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 123 and 173 amino acids in length. There is a conserved IPPYN sequence motif. The gene that encodes this protein in humans, is found in the chromosomal position, C17orf98.	27.00	27.00	28.20	33.80	26.60	23.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-10.63	0.71	-4.22	9	48	2012-06-28 09:40:34	2012-06-28 10:40:34	1	2	36	0	36	51	0	121.10	49	77.44	NEW	LE+uFVLDuluVuolupshp+tpPKhhoAIPPYNAQpD+HApsYFcS.sVpslL++TtQ....spsGsohsGhllD+ahhhG........tGttYlspRNhsGAG..........HSpptVsGHs.ahsshpshp.GapGhFGaRRNTPpLRppPSsF	..hEKuFlLDuVAVuohucs.as+tpPKlhSAIPPYNAQpDhHAcsYF......pS+sV.slLRKTsQ....c+GGTutcGhllDhhalhG........tGpcYLs+RNhA....GuG..........HShppVsGHs.a.usl+sh..GaNGpFGYRRNTPsLRppsSsF.................	0	16	18	22
+14927	PF15076	DUF4543		Domain of unknown function (DUF4543)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0P5P2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 90 amino acids in length. The human member of this family is C17orf67.	27.00	27.00	75.00	75.00	22.30	19.60	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.80	0.72	-3.95	4	35	2012-06-28 09:57:32	2012-06-28 10:57:32	1	1	31	0	22	30	0	72.90	78	80.11	NEW	aT.DASPILsEKpAKQlLRo+RpDR.pKsGaPDEPMREaMLaLQtLEQRuEEQFLEHWLNPHChPHCsRNlVHPV	.ht...-uSPI.LpEKQAKQLLRSRRQDRP.SKPGFPDEPMREYMHHLLsLEHRAEEQFLEHWLNPHCKPHCDRNhVHPV..	0	1	2	8
+14928	PF15077	DUF4544		Domain of unknown function (DUF4544)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q3KP22	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 118 and 256 amino acids in length. The human member of this family is C11orf85.	27.00	27.00	28.60	28.50	22.20	17.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.24	0.70	-4.85	6	50	2012-06-28 10:05:16	2012-06-28 11:05:16	1	2	29	0	21	34	0	161.40	51	91.32	NEW	MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRsVLGNLDsLQPFATEHFIVFPYKSKWERVSHLKFKHGEsVLVPYPFVFTLYVEMKhFHEsLSsGKPhsDSPLGLVLAERKAAtAsM+..KRKpsEVPSSPSRPGLDRs.........uKc........KP.p+cs+R.hphhsshstscVtsQ..h.csu.tGphlP.pppos.h.L+sPpphtssu.hGF	...MSLKPFTYPFPETRFLHAGssVYKFKIRY...GpuIRGEElEsKEVIhpELEDSlRsV.LtNhDsLQPFs..T-HFllFPYKu+Wppsu+L+FKHtphhLhPYPFVhTLYlEhKhFp.EsLssG+..hps.s.ths.scp.....cs.ts.h.hc...KR+hh-....sostpst.....pR...........tpc........p..pcps.pp.h.......hsh.shscl.pt.....tps..G.h....pps.........c.....t..u.hG..............................................	0	3	3	5
+14929	PF15078	DUF4545		Domain of unknown function (DUF4545)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JVX7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 417 amino acids in length. The human member of this family is C1orf141.	27.00	27.00	30.80	30.70	21.30	21.00	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.79	0.70	-12.61	0.70	-5.57	4	51	2012-06-28 10:14:33	2012-06-28 11:14:33	1	2	20	0	18	46	0	233.80	39	100.21	NEW	MsE+IL-KhDhL-EpA+hLhAhRtKpsshppplKKKs.lhPLhFDaplcFt-sIssShSKT.upIpKD+upslKKsKR.VSFK.pPcPp+SDFEcSsLRPPhLsTsIphpE.K.hE.tEE.LKSRSh.Sh+YLKDpsETE.AKPh...h.....................................sQHcpps++ohcSTsaSusSSppsptp+.Ess.h.TKEsEhhRNDQhpch.sV+Qp.LLPLshED.LKsPchKhIDluPscTVpopMcpNcsNPIIFa-TcYVQMLhLTK.RhsPauhc......ap+pNlVLE+NCEhLKolhpDps.TsSKsppThsssQpKcl.slShElup+sls-Kh+KKpc+.s.cpIS.spLYNlSQTFSSLoKKFVGahDKsVIQEKSsKss+FE+.FSpsKPss..KFos.PlKYsSKP.+NILclHKlNNlTPLDsLLs	.....................................sphQsph+Kps.hhPLTFDFplpFEcs.s.s.htKt.spIpcs+.sh..shp.psch.ssh+.....p.......s.pspFpp.slt...h.s.hp..pE..c.............................................................................................................h............pEsp......hp....htpp.hhPLshED.LhpsphKhl..t...p...ph..........................................................................................................................................................................................................................................................................................	0	2	2	2
+14930	PF15079	DUF4546		Domain of unknown function (DUF4546)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5T0J7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 88 and 212 amino acids in length. The human member of this family is C1orf49.	27.00	27.00	76.30	35.60	21.70	26.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.81	0.71	-11.23	0.71	-5.17	5	48	2012-06-28 10:17:19	2012-06-28 11:17:19	1	2	20	0	16	49	0	178.30	66	92.20	NEW	MSAKRAE.KKTsL.......SKNYKAVCLELKPEPTKTYDYKGsKQEGhFTKsGsT+ELKNELREVREELKEKMEEIKQIKDlMDKDFDKLaEFVEIMKEMQKDMDEKMDVLINIQKNsKLPLRRuPKEQQELRLlGKTD+-PQLRl+KMD...GuDGsPLALHKKlVAPQpT.+sPLDPLHpCsoCCEKCLLCALKNNpNRG+.saHAWusFSPL	..................MSAKRAELKKTpL........SKNYKAVCLELKPEPTK...TaDYKuVKQEG.FTKsGsTp-LKNELREVREELKEKMEEIKQ..IKDlMDKDFDKL+EFVEIMKEMQKDMDEKMDlLINhQKN.KLPLRRuPKEQ.QELRLhGKTcp-PQLR.KKMD...GssGAPhuLHKKsMAsQKs.pssLDsLHpCtoCC.EKCLLCALKNNhNpGt...................................	0	1	1	1
+14931	PF15080	DUF4547		Domain of unknown function (DUF4547)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q147U7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 144 and 206 amino acids in length. The human member of this family is C3orf43.	27.00	27.00	101.90	101.70	20.10	17.50	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.38	0.71	-4.89	3	28	2012-06-28 10:20:18	2012-06-28 11:20:18	1	1	22	0	16	37	0	189.00	76	93.09	NEW	DHKLQALETQFKELDFIKDNLTQKFEHHSKTLASQAAQDElWTAVLALpFTSMELNILYSYVIEVLICLHTRVLEKLPDLVRSLPTLASVLRRKVKNKRIRsVWESILEEaGLQEGDITALCTFFVAHGNKAEHYTAKVRQMYIRDVoFMITNMVKNQALQDGLLRAVQVIEKGKAsRTPEcpKSPLKELIPSVKu	.D+KLQALEsQFKELDFTKDNLhQKFEpHSKoLASQAAQDEhWTAVhALcFTSMELNILYSYVIEVLICLHTRVLEKLPDLVRGLPTLASVLRRKVKNKRIRVVWESVLEEpGLQEGDlTALCTFFIAHGNKAEHYsAKVRQMYIRDVTFhITNMVKNQALQDuLLRAVQVIEKGKAVRsPEcQKSSLKELIPSVKN.......	0	1	1	3
+14932	PF15081	DUF4548		Domain of unknown function (DUF4548)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95561	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 178 amino acids in length. The human member of this family is C1orf105.	27.00	27.00	65.70	65.70	22.80	21.90	hmmbuild  -o /dev/null HMM SEED	167	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.03	0.71	-11.06	0.71	-4.71	4	26	2012-06-28 10:27:17	2012-06-28 11:27:17	1	1	16	0	9	25	0	132.00	63	89.87	NEW	PWLSEASLVNKPLlLSlP+RYP+tSushLsSsKKsMsLPlLhQsP.DshSKARRNQs-sMLlRNpQLCSTC...QEhKMVQPRTMpIPDc.KsSFENsMSaR.MSLHpPKhQssscs.+sDIPTESI+YRLPILGPRTAVFHGLLT-AYcTL+EpQ+SSLPRKEPhGKTsR	...PWhsEAShlNKPLlLSlP+RYP.tSushLsSs++shshPhhhQsP.DshSKARRNQpssML.hRNpQLCSTC...pEhKMVQPRshpIPD.D.KsSFENhMSaR.MSLHpPKhQssscsa+cDIPTESIH.YRLPILGPRTAVFHGLLo-uYKTLpEpQpSSLPRKEPhuKThR..........	0	1	1	2
+14933	PF15082	DUF4549		Domain of unknown function (DUF4549)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5T699	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.	27.00	27.00	35.90	40.40	21.30	18.50	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.81	0.71	-4.55	4	24	2012-06-28 10:34:07	2012-06-28 11:34:07	1	2	20	0	19	27	0	128.00	53	23.05	NEW	DplYKlSSTERV..LEKELtspLsELKsplE-pGlL.GTsNRsaSSlthPKDssaFR+EREhhLKKsLQVAEuKPLVIQADlhpRELESCLpREYTstsLPLLLhQaYT-RItQLuQSKYLHhLRWKRFCp+SphhEpLYPLYp	.......................DplY+lsSoERlp.LE+cLthpLsELKsEIEEpthh.sst..p+s..aSSVphPKDltaFR+EREhALK+sLQVAEuKPLVlQADVMQRELESCL+REYTsENLPLLLhQaYs-RIpQLsQsKYLHMLRWKRFCpHSphhEQLYPlYp.........	0	8	10	12
+14934	PF15083	Colipase-like		Colipase-like	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NCL2	Family	This is a family of colipase-like proteins.	27.00	27.00	31.50	28.80	25.70	25.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.17	0.72	-10.80	0.72	-4.05	9	62	2012-06-28 10:57:55	2012-06-28 11:57:55	1	3	22	0	35	60	0	71.90	41	90.69	NEW	polh.pClsapKsNuhpCs+HSECpSsCClpspppsttFC.sP+o.IhhpClPhRKsstsh...CpptpEChSpsCl..pE....+Cs+RstlL	...................hpK..s.hCpcHsECpSsCClhss.ssppFC.ss+o.IhhpClPW+Ksshth...Cp.t.pC.p.p.h..............................	0	3	3	7
+14935	PF15084	DUF4550		Domain of unknown function (DUF4550)	Bateman A	agb	Jackhmmer:Q9ULG3	Family	This presumed domain is functionally uncharacterised. This domain family is found in eukaryotes, and is approximately 100 amino acids in length. This domain contains an N-terminal HXE motif.	27.00	27.00	52.70	51.30	23.40	22.90	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.13	0.72	-3.89	8	33	2012-06-28 11:36:29	2012-06-28 12:36:29	1	3	30	0	20	49	0	98.00	47	16.75	NEW	spsaaHIEY.hhPcD.cspKlDlVlassVAKl.......Fh-sph.Kssp.h+.ssDpsW.lsWspsaslsVsp-hlpchh.+tlsl+laDo+-KVSs+ARaDRsKsht	.....h.ppaaHIEYaLLPDDt.EP+KVDlVlF.shl.AKV.......FL-Sus.KTV+PWc.EGD+sW.VSWpQTFsIsVTKELL+Kls....h....HKITL+lWDoKDKlScKsRY.R.Ksh.s....	0	9	10	11
+14936	PF15085	NPFF		Neuropeptide FF	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O15130	Family	\N	27.00	27.00	34.50	32.50	23.70	22.50	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.94	0.72	-10.78	0.72	-3.76	9	43	2012-06-28 11:36:44	2012-06-28 12:36:44	1	1	29	0	15	40	0	90.30	49	79.89	NEW	stuhpp.ppshsc-D.tP.ssp-thscphhphsup.......................lLRuLL.u.QR.sRs..SsLaQPQRFGRsopGsh.sEpph.psRsWEussuQhWShAsPQRFG.KK	...........................................................................................-sph.so..........LLRsLLQAMpRPGRS..uFLFQPQRFGRN.opGSWusEcL...SPRAhEul..........supFWSLAAPQRFGKK.	0	1	2	5
+14937	PF15086	UPF0542		Uncharacterised protein family UPF0542	Bateman A	agb	Jackhmmer:Q7Z3B0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved LSWKL sequence motif. This family includes human protein C5orf43.	27.00	27.00	47.90	47.80	24.20	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.57	0.72	-4.26	3	46	2012-06-28 11:42:20	2012-06-28 12:42:20	1	2	45	0	33	41	0	73.30	71	82.43	NEW	M..FDl.KAWL-pV....VcWAA-DPGuFlTTVLLuLTPFFLlSAVLSWKLAKtIEAE-KRcKp+pK+ptNlAcsRRpKKD	.............MhDl.KAWAEYV....VEWAAKDPYGFLTTVILALTPLFLASAVLSWKLAKMIEAREKEQKKKQKRQENIAKAKRhKKD........	0	8	9	18
+14938	PF15087	DUF4551		Protein of unknown function (DUF4551)	Bateman A	agb	Jackhmmer:Q8IXR9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa. This family includes human protein C12orf56.	27.00	27.00	36.80	62.90	17.10	23.60	hmmbuild  -o /dev/null HMM SEED	617	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.20	0.70	-12.95	0.70	-6.15	7	68	2012-06-28 11:45:46	2012-06-28 12:45:46	1	2	35	0	29	57	0	424.10	47	94.34	NEW	MA.....tsuhsstpNu+LDuFL+RshssplY-plRuaEPClVVS-p.c+sFhaVlLSD-plYLTEpPPRslphsVsh+cIhuI-LIsDhP-FLSGpDREpsQHIRIhY..................ussp.shPtptthutsppssc.sst.h.h.sphS.ohspu..sLtuspcposthtsspst.stsL.c.p.tt........................hPp.s..sspss.spcpstshPsssssshtsps.ssstss.spts.p.ptssptht.hsSllup.lppspshc............cc-uELHLYhlSsTSplaL+LpSoWNsYIIRuT..Lh.DPlYhpcpss....pusp.........p.EcphplFsQLpuELL.csssLEplahLLQEL+sAApRNhsLK+LFWKosDLF.FLVppLp-..L.tscstpshpt..ppADcLhlsh.lsQTLuhMFRET-l-ssRLshLsAcpGshh.pLLlhLlscPph.h.....p.p..tp...............cs-lQtLht-YhDsAsuLLFEllLlsQpushsssss...............phhsluWlhphLpspP..lhsFluh.scpsVhsLSsot.t.LSPuQAlLLYQphhlLhuCLQaSppLupaIRssa+EEFRYFl+hPslEcKLPspYPIopPsh+LlpplLphl.	.......................................................................................................lsDhPpFLps.ppphsQHIplha...................................st..p....h.hth..t..ppphp.....p..s......h...p....p.tts...h.......................................................................................................................................................................t.................................................................................hchY.lp.tS.h...hps.Wpsh...h...................................ppEcphphFsQL+uELh....cs.olc+lh.Ll.EL+sAAp+shhL++LFWKosDLFhFLVspLcE.hLstsp.stpuhpstsp..csDcLh...hsh.llQTLshMFRETEhEsuRLNhLsA++usLh.pLLllLlscPpl.p..tss..sh.p.sss..........st.....hsh-scLQpLlhEYhssAouLLaElLLlhpQushs.s..us...............pF.uluWhhphLQspP..lhsFlut.VcplV.p................sLSss..p.LoPsQAVLLYQphhlLhuCLpaSppLupalRssa+EEF..RYFl+hsslpc+LP.pYPIopPThpLhcElLpll............................	0	9	10	15
+14939	PF15088	NADH_dh_m_C1		NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O43677	Family	\N	27.00	27.00	39.60	39.40	22.20	21.80	hmmbuild  -o /dev/null HMM SEED	49	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.26	0.72	-8.49	0.72	-4.46	7	40	2012-06-28 11:47:20	2012-06-28 12:47:20	1	1	32	0	17	39	0	47.10	70	65.75	NEW	hFhspcPspupPNWL+VGLsLGTolFlWhhLhKQHN-DVhEYK+RNGLE	.......KFYVREPssuKPsWLKVGLTLGToVFLWlYLIKQHNEDVLEYKRRNGLE..	0	1	1	2
+14940	PF15089	DUF4552		Domain of unknown function (DUF4552)	Bateman A	agb	Jackhmmer:Q86WS4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. Proteins in this family are typically between 425 and 649 amino acids in length.	27.00	27.00	150.10	149.90	22.70	21.80	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.66	0.70	-5.58	5	29	2012-06-28 11:47:55	2012-06-28 12:47:55	1	1	23	0	14	25	0	374.50	62	67.71	NEW	SsGN+sFLT+os.uVVMGEDCGShDERRQSDFITEKpSlQHIWGENRKEhSNFLEDVNQsTssLLSENCDSFIScNMINLLNIDQQ+IKKTFDKCDYDoMuDsssVlSSDKNHsTDRCIRSIFTDPELsFSNSTFNKoSYPEKCQPNK.CQKEYsNNERNsLSTSFEKDaYPASS-+KGKFENDYQEKTPQ+co..QKYPVNHMuNIPLEELHSKQSWDFGlGE....ILMcEGGhsSLKu+sTSTKKs.YLDSSQSSQSTSYSPRPTD.SCFSSSSEMPSEDEDQI.QQIEDSNRpSIKsKETTNNFYLEsM...sKLPsD+IIKNNAKhHKQNENFHQFShKNNTDQFPQSQCNSAHILQNKTosNCILQlARCDAWVQTESEsVMEEKLDlAIQCDIISKCKCRS.......-VSsLCNVERCoENlKADTTGGQEILKNN	...S.GNRNhLTcpP.sVlMsEDCtSMsEhRQSDaITEKpSlQHIWGcNtKElSNFLEDVNQssPslLSENCDSFVSQNMINlLNIDQQ+IKKTFsKCsYDSMGDhCsVTuSDKNcsTDRCIRsIFTVPELT.FSNSThNKTSYPEKCQPNKphQ+EYNsNERNDLSTSFEpDhYPuSSE+K.GKhENDYQEKsPQKsI..QKYPsNoMssIP.EELHtKQSWDFGlsE....ILMcEGGhsSLKup.PTSscKI...LDSuQSSpSoSYSPRPTD.SCFSSSS-h.SEDEDQl....QphE-SN+hsI+scEptN.....NhalEpM...sclss-cIlKsNsKhHKQNENFaQaShKsNoDpFspSQCNSAHlLQNKTssNClLQsuRCDAhVQTEoEslhcEKLDAAIQCDlIScCpC+s.......-lS.LsshcpCotNlpuDTTGGQEIhpNN..........	0	1	1	2
+14941	PF15090	DUF4553		Domain of unknown function (DUF4553)	Bateman A	agb	Jackhmmer:Q8N655	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. This family includes the human protein C10orf12.	27.00	27.00	45.20	45.10	24.00	22.70	hmmbuild  -o /dev/null HMM SEED	463	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.77	0.70	-5.49	7	61	2012-06-28 11:50:07	2012-06-28 12:50:07	1	1	32	0	32	58	0	389.50	41	45.00	NEW	shDslhsspPthhhWssptpNppLltEhNspa.plppuWlQ..lpt-ptssshs+s+scphp-.haKspp.hcpChhtLEV...SPVpMLF.KpapLsclCpWFhpTTETpSLslV+KhNsR.Ph-l.ss+t.h.phpsSs.....hpsphh+KHhKKFAhuoPu+sshKhphLathlppss.pscup.....oLu..tcsphcclpp-Rhup.tppl.o.uoschhpKhpNlRhhhpsQh.......hpss.G.tsusEsppsppols.pslhsP....shpstspphsspschss+sph..........pto.psppshpKtps.schpssphpupo.+cs+lhh+Khsplcp.ps.phsshhhpPtuh-psu..s+ps..cEs+hh..+ppss+pss.p+ppcEppsh+sspPs..ottlst..cpptLscusspspps..sscthuphppRtRP.hKosE.sstpR+++.psptsp.tuhhs+hpst	.....................................slDslhsppPphh.WsspppNppLltphNspa.plppuWlQ..lp+-ttsssht+s+s.cp.p-..haKspc..cpChspLEs...SPVpMLF.......ppacLsplCpWFhpTTETpSLsIVKKhNsR.Ph-l.ss+tsh.thpsSs......hpAphl+KHhKKFshuoPu+sshKhp.hLath.hpps..p.lcsp..........s.u..pcsphcclp....c-R.p+.s.t.l.s.uoschhpKhpNlRhhhpsQ........hpps.u...u.spsp.uppoVs.pslhsP....shpss...spthsshsc.ppthph..........ptspp.hpc.h.Ksph..p.chptsphpot...s.....pcs+h.hhKhsp.cphss...phsshhhpPtuhDpsu..s+phphcEsKhhh..+ppsu+pss.p+pp+E.pst+ssps...s-thst.hpppth.scssshspps..tsch.uphpp.....+tRP.hK...osE.ss.pR+++.psp.sp.tshhp+.......................................................................................................................	0	2	5	16
+14942	PF15091	DUF4554		Domain of unknown function (DUF4554)	Bateman A	agb	Jackhmmer:Q8N6T0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.	27.00	27.00	52.30	43.80	18.70	23.80	hmmbuild  -o /dev/null HMM SEED	458	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.53	0.70	-12.37	0.70	-5.75	4	51	2012-06-28 11:52:02	2012-06-28 12:52:02	1	2	24	0	17	40	0	291.10	58	83.54	NEW	MTDsLVIK+FL+KIlhVHsKl+FpFSVKVNGlLSt-IFus....ENEPsLsLuNGISLhlshpHYVS+PpFshsE.pCSRIHPVLGHPl.LhIPsDhAsMGLLGELhLTPAAALCPsPKsaSNQLNRISS.lp...IFLYGPhGLPLlhss.EQPpTohF+DhuhhlDWKKapLsMlPNLDLsLDpshlLPDVsYpVE............ssEcsQSQs.cuQtQTLLLFLFVDFpSsFPVQQsElWulaTLLTsHLssILsES+SsVQsSIQssVDpsLEpHaQtAKs+Q+LQASLSVAVsSIMSIlTGSTsSSFRKhCLQoLpAsDTQEFpTKL++sFp-ITpHpFLs+CSC-hcQclT.ccp.oAQsTcDthcs.suLEhhh-ouGQsENKRLK...cuS.phutccopThPsuc-usssEsssppssPTstutpsp.upuphtssGsththsupssth.-sLWLQEVSNLSEWL	................MTDCLVIKpFL+KllhVHPKlRFpFSVKVNGlLSpElFGs....EpEPsLsLsNGIuLlss.pHYh.psthsshE.hCSRIHPVLGHPVhLhIP-DhsshsLLGELhLTPAAALCPs.Kl.uNQL.s+ISo.lt...IFLYGP.GLPLh.sp.tp..hshhps.s.hlsWKKapLphlPsh-.pLpps..hhPDhsYplE............s.p.ts..psps.t..tpsLLLFlFhDFpssF.sQ.hEhhts.sLLpsHLssILhcs+shVQsslphslDpsLpQHpQtsKs.Q+.............................pshps.pspEhthpLtp....hh....h..h..t.t.......................................................................................................................................................	0	1	2	3
+14943	PF15092	UPF0728		Uncharacterised protein family UPF0728	Bateman A	agb	Jackhmmer:Q8N6V4	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa. There is a conserved GPY sequence motif.	27.00	27.00	76.20	32.00	19.90	18.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.14	0.72	-9.92	0.72	-4.11	10	35	2012-06-28 11:54:29	2012-06-28 12:54:29	1	2	30	0	25	42	0	85.10	57	77.93	NEW	MPppuhVslRYGPYsusGl.V-HRTtRL-GLQAVLtpDGHpVlLEch-DaNsVELlVNGEhVFpCsIp-L-......FGGDG+LDP.......LCcEAhpAV	.......MPcpAlVhlRYGPYSAs.GLsVEH+TaRLpGLQAVLspDGHcVILEKIEDWNlVELhVNtElVF+CNIpDLE......F.GGDG+LDP.......LCccAhhAV................	0	7	10	13
+14944	PF15093	DUF4555		Domain of unknown function (DUF4555)	Bateman A	agb	Jackhmmer:Q8N865	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in metazoa.This family includes the human protein C7orf31.	27.00	27.00	75.20	64.90	25.50	23.70	hmmbuild  -o /dev/null HMM SEED	289	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-11.96	0.70	-5.51	4	43	2012-06-28 11:56:23	2012-06-28 12:56:23	1	1	32	0	29	47	0	246.30	53	49.21	NEW	MtsTtshP.....hh+Es.ulshLSsTahSs-LaoPLpospR.TssEspappaRtplt+ss...+sP....WGpc+.cYGGhtPl.LPspaRPKsEPPphVtKuH+HYGSGhp.aP................cthPlpQ.YphTp.phSclRhNDpLLPpP.puslhsh.lctPaPtEHPYtSHIs+hulFPs.sSPc-..ttltstpp......PhPspsPTpP.p.hl..Ko+GsPaRaEl.Dhspcs.+++ALsW.GpssYp.hptssptsR..hYPtPPKohtPN.s.ps.hs.ths.+pssshRslcKSthhToYppc	...........Mtshpshs....hhp+EhpGsDlLSsTahSNclaTPLppshRsT..sSpcRYpELR-oLpps....RLP....WGu-R.EYGGlhPloLPE-H.RPKsEPPplMuKGHpHYGFGG-sW..P............................................................................................................RclPIEQaYaLTQsKKSclhsNDSLlPKPP.sS.sltc..IshPaPlEHPYpTHIsRsAMFPoFsS.PcDhhTGlcARsp.....QPFPPTlPT.....KsaDsslL.KT+GNPYRa.EllDhPhDS.KKKALsWPGQslYashP+sspKs+.lF...YPKPPKohAPNoohps.hDsh.sh+pANIpRNLERSpWlToYs+..........................................	0	11	11	15
+14945	PF15094	DUF4556		Domain of unknown function (DUF4556)	Bateman A	agb	Jackhmmer:Q8N9H9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrates. This family includes human protein C1orf127.	27.00	27.00	36.50	36.30	18.80	17.50	hmmbuild  -o /dev/null HMM SEED	206	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.39	0.70	-11.45	0.70	-4.77	3	33	2012-06-28 11:58:33	2012-06-28 12:58:33	1	2	21	0	11	33	0	196.40	68	35.49	NEW	+CPMhsARLGcESV+CcPpFIQVSRPlPhhsDusQTPWLLSLRGELVASLEDASLMGLpVDlGATsVTVQSPRQELLQR.E.........PLhhVSGuhhh.hpQAlPLVSpQPtSEVuVHIPKQRLGLVKRGShlEEoLS.RFLcVpQo-oFpVs...Es+DFVlVSIPouslLQsQsCQcuc-oPGTQAFYRVDLSLDFAEMAuPVhWTVEsFFQC	.....KCPMlpSRLGQESVHCGPhFIQVSR.PLPLhpDspQTPWLLSLRGELVASLEDA.SLMGLYVDlNATTVTVQSPRQsLLQRhE.............VSGt.....psAhP.s...VShQPESEVLVHIPKQRLGLVKRGSalEETLSLRFLRVHQSNhFhVT...EN+DFVVVSIPAAuVLQVQpCQEssGoPGTQAFYRVDLSLEFAEMAuPVLWTVESFFQC......	0	1	1	2
+14946	PF15095	IL33		Interleukin 33	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95760	Family	\N	27.00	27.00	78.10	27.40	21.50	22.00	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.77	0.70	-4.94	4	41	2012-06-28 12:02:12	2012-06-28 13:02:12	1	2	23	1	13	44	0	204.20	59	97.66	NEW	MKYSTsKISPAKhpsoAuKALV.ssKLRKSQQKscEVCphYaMpLRSGLhIcKcsCYFRKEsTKRaSL+o..tpptpppthslsuppcphpt.......sFshth.hltsastuhthsSIph...lTEasASLSTYNDQSITFVLEDGSYEIYVEDLtKsQEKDKVLLRYY-SQpPSspoGDGVDG+pLMVNLSPTKDKDFhLHANsKEHSVELQKCEspLP-QAFFVLHcpSSpCVSFECKssPGVFIGVKDNpLALIKhtDpsps....NIhFKLS	..........MKYSssKhSsAKhpsoAu+ALs...Klt+SQQK.scElCphYaMpLRSGLhIcKcuCYFR+EhTKR.S.+o..tt....tthshsupppp..................h.thttth...t..Sl......lpE...ASLSTYNDQSloF.shEstuY.I.VEDhtKspcKDKVLLpYY-SQpsSsEo...GDGVDG+hLMVsLSPp..KDFhLHANsKEHSVELpKCEpsLPDQAFFlLHpp.....sSpCVSFECKssPGsFIGVKDNHLALIcs...-.opp.....NIhFKLS.......	0	1	1	1
+14947	PF15096	G6B		G6B family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95866	Family	\N	27.00	27.00	161.30	160.90	22.00	18.00	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.58	0.70	-4.83	5	39	2012-06-28 12:10:19	2012-06-28 13:10:19	1	1	24	0	16	49	0	203.90	70	89.65	NEW	NPGASLDGRPGDRVNLSClGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFuGRLRSLDoGIRRLELLLSAGDSGTFFCKGRHE-ESRTVLHVLGDRAYCKA.........PGPTHGSsYP+lL.IPLLGsGLVLGLGsLGhsaWR+RRlPPpP.cPhPRFA...PllsT......EuQRPl+EQDuKhPGcLDQEPuLhYADLDH.sLpR.RRhSsssPuDA.STVYAVVV	......ssGASL-G.RPGDRVNLSClGVSHPIRWsWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFsGRLRSLD.sGIRRLELLLSAGDSGTFFCK...GRHE-ESRTVLHVLGD+s.C+s.........PG.PT..HGSsYPQlL.IP...LLGAGLlLGLGALGlVWWh+R+.PPt........Ph.P+hA.....Phsps..........................EsQ+..ss+..c.p-s+hsGc.D...p.EsuLhhu.............s.h.stc..sTl.uhss................................	0	2	2	3
+14948	PF15097	Ig_J_chain		Immunoglobulin J chain	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P01591	Family	\N	27.00	27.00	75.90	57.10	17.70	17.40	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.95	0.71	-4.57	4	36	2012-06-28 12:14:02	2012-06-28 13:14:02	1	2	26	0	21	57	0	126.70	71	78.70	NEW	-DEpTVLVDNKCpCsRlTSRIIPSs-sPsEDIVERNIRIIVPLNsRENISDPTSPLRTpFVY+Lo-LCKKCDPVElELssQlhpAoQSNlCsEDs...ETCYTYDRNKCYTThVPhsY+GpT+MVpAALTPDSCYPD	..EDEchVLVDNKCpCsRlTSRII.Ss-DPsEDIVERNIRIIVPLNNRENISDPTSPlRTcFVYHLS-LCKKCDPsEVEL-NQlVTATQSNlCDEDs...ETCYTYDRNKCYTssVPLsYsGcT+MVpTALTP-SCYPD.	0	1	1	6
+14949	PF15098	TMEM89		TMEM89 protein family	Bateman A	kh6	Jackhmmer:A2RUT3	Family	The function of this family of transmembrane proteins, TMEM89, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are approximately 159 amino acids in length.	27.00	27.00	162.40	44.70	20.00	18.70	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.87	0.71	-4.14	5	25	2012-06-28 12:19:38	2012-06-28 13:19:38	1	2	22	0	14	28	0	126.50	69	84.98	NEW	WSRPLWYQVGLDLQP..........WGCQPNSLEGC+uSLGCPGYWMGLGuNRIYPVAGVTITTTMMLllSRslhQRRRSQAoKuEHPQVTssPCssWKRR.uPISDRTLLLGVLHMLDALLLHIEGHLQ+LAoQcQIQIKGTPs	...WSRPLWYQVGLDLQPWGCQPsSlEGCcuuLuCPGYWhGLGus.RIYPVAGVhITTTMMLlhuRhlhpRRRSQATKu..EHPQVTTpPCGPWKRR.sPISDRTLLhGVLHMLDALLlHIEGHLQ+LATQpphQIKGTss..	0	1	1	2
+14950	PF15099	PIRT		Phosphoinositide-interacting protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:P0C851	Family	The function of this family, PIRT, is not known, however it is predicted to be a multi-pass membrane protein. This family of proteins is thought to have a role in positively regulating TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). This family of proteins is found in eukaryotes. Proteins in this family are located in the cell membrane [1]. Proteins in this family are approximately 140 amino acids in length.	27.00	27.00	39.00	38.00	26.80	26.40	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.85	0.71	-4.92	10	80	2012-06-28 12:20:04	2012-06-28 13:20:04	1	1	40	0	50	69	0	125.90	42	88.69	NEW	hssPsu.s-.shhEKssps........ssslslPLVsEsQLTAATGGAELSCYR...CTlPFGVVlLIAGIVVTAVAYoF...NSHGSlIShhGLVLLSuGLlLLAsSAlCWKsRhc+K+c+RRESQTALVsNpRslFs	..........................t..hPKs..pssphp.psps........ssshsls.h..SEspLTsATGGuEhShYR...CIhPFGsllLlhGlVlTuVAYoa..............Nops.....S...l...lphhGlslLShGLhLLssuhLCWpsp.++Kpt+RpcSphhhshpph.Lh.t........	0	3	6	17
+14951	PF15100	TMEM187		TMEM187 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q14656	Family	The function of this family, TMEM187, is not known, however it is predicted to be a multi-pass membrane protein. Members of this family are as yet uncharacterised. This protein family is also alternatively named ITBA1. This family of proteins are found in eukaryotes. Proteins in this family are typically between 239 and 267 amino acids in length.	27.00	27.00	36.50	34.50	21.20	24.50	hmmbuild  -o /dev/null HMM SEED	242	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.07	0.70	-11.62	0.70	-4.99	10	38	2012-06-28 12:20:47	2012-06-28 13:20:47	1	2	35	0	21	36	1	226.10	56	86.68	NEW	ALhHVslssCLClulshTGlFDuVhV-lGY-HYAEpPVss...LPuaLAMPFNSLVNluYlLLGlYWLpppsssspsst.............cAcYlKDVFAhMAlsYGPVQWLRlsTQpRssAVLDQWhTLPIFAWlVsWC.aL-+..GW+sphhLulEslSlsSYuLuLLHspGFElA.LGhHIssAVhpulp....sQtRaGs.ssStpYLsLAVLSCuGFVVLKLhDHpLA+a..cLFQpLTGHFWSKVCDlLQFHauFpFLTs	.........................................................................................................AhhHVAluusLCsssVaTGlFDuV.V.pVGYEHYAEsPVsu...LPAFLAMPFNSLlNlAYsLLG.laW.Lp+ssss.stss................+YlKDVFAuMAL.....lYGPVQWLRls....TQh+hsAVLDQWhTLPIFAWsVAWChaL-+.....GWcPWhhL....ulEslSLsSYuLALLHPpGFEVA.LGsHlsu...AVupAL+......................spp+aGs.ssSspYLsL....GlLSCL.GFVVLKLhDHpLApW..pLFQpLTGHFWSKVCDVLQFHFAFlFLTp................	0	7	9	11
+14952	PF15101	DUF4557		Domain of unknown function (DUF4557)	Bateman A	agb	Jackhmmer:Q8NHR7	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved TVF sequence motif.	27.00	27.00	27.20	27.10	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.50	0.70	-11.26	0.70	-4.49	5	40	2012-06-28 12:20:57	2012-06-28 13:20:57	1	1	29	0	25	36	0	188.00	62	92.08	NEW	FpuQ+AWFSuSVSpDlpphWVcEGGsISD.s+sADFLFSsDASHsDTtRIYpS-DYlcDpATVFHupaLtAssNscSpsSVs..LGHYVL.........PP-s............lQcElRuKIGSF.IWEQDEpFl....lp+c-chsPsc...pslpcpupsos-Hspcpp+Ss-aatTRTslscKspsash+s................YPVNNM..VoGYlSIDAhcKa.GE..L+DFlPGsuGahVh+sscs	......FQGQRGWFCsSVSp-LRQFWVAEGGoISD.s+AADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANA..EI..KsSVA..LGHFlL.........PPAC............LQK.EIRRKIGSF.IWEQDp+Fl....lcKHDEVsssE..lcshpEsS.cluT-HcKELScSsE+HhhRTPVlEKQMYFPLQs................YPVNNM..VT.GYISIDAMKKFLGE..LHDFIPGSSGYLAYHVQsE............	0	4	5	6
+14953	PF15102	TMEM154		TMEM154 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6P9G4	Family	The function of this family of transmembrane proteins has not, as yet, been determined. However, it is thought to be a therapeutic target for ovine lentivirus infection [1]. This family of proteins is found in eukaryotes and members are typically between 138 and 320 amino acids in length.	30.30	30.30	30.30	30.30	30.00	29.40	hmmbuild  -o /dev/null HMM SEED	146	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-11.17	0.71	-4.49	7	50	2012-06-28 12:21:22	2012-06-28 13:21:22	1	6	36	0	27	44	0	129.00	39	50.53	NEW	sE-sppSuc.slpstsh.csos...................soshuoVT.sE.....slssshs.sph...pssssQhEh...............lLMlllP.llLsLLlL.llhllhhh+R+RsKpc..p.spppt...p-lssEslh.P............IFEEDTPSVMEIEMEELDKWMNSM.....N+NADhEsL	................................................................................ph....................sshsulT.sp.....slssshssop..h....st-ps..QhEF..........................lLMVlIPh.lLLsLLlLsV.lhlshhh.+RKRs.Kp-soSpGSpssLQ.o.E.lusEsl+sP............IFEEDTPSVMEIEMEELDKWMsSh.....N+Nssh-t......................................	0	6	9	14
+14954	PF15103	G0-G1_switch_2		G0/G1 switch protein 2	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P27469	Family	This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers [1].	27.00	27.00	66.30	66.20	21.80	21.30	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.49	0.72	-10.47	0.72	-3.79	8	46	2012-06-28 12:22:18	2012-06-28 13:22:18	1	2	34	0	23	43	0	103.30	54	90.29	NEW	METlpELIPhAKEMhuQKPSRKhVKLYlLGSVLAFhGsVlGLVETVCSPFTuupcL.DpEtA..lAEhcsAhERptlppp...........slhEcsKpppss.psRulSpRpHA.S	METlpELIPhAKEMhuQKPstKMVKLYVLGSVLAhFGVVlGLVETVCSPFoutupL.DpEtt...lsEhcsA..htRpthppp......................hlhEpuKppsss.tpRulSpRpHAS..............	0	1	3	9
+14955	PF15104	DUF4558		Domain of unknown function (DUF4558)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VU69	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 78 and 121 amino acids in length. One member is annotated as being a flagellar associated protein.	27.00	27.00	27.40	27.00	26.20	26.80	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-9.86	0.72	-4.06	11	43	2012-06-28 12:22:34	2012-06-28 13:22:34	1	2	40	0	28	44	0	85.30	39	79.28	NEW	pchsptcchspc.cpssphs.WpEphppp....ssht.sspph...pcphcpElplAN+plhtlRpAtL+cLaEcEtppaEQELstpGhAhYccRt	..................pchhthcKhlp+hcssppcshWp.sLspR......cssh.Ahl+h...pcshspELsLAsKpLLhVRQAtL+pLFE+EappYpQELsph.GKAFYhER....	0	10	15	16
+14956	PF15105	TMEM61		TMEM61 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N0U2	Family	The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 150 and 211 amino acids in length.	27.00	27.00	27.80	41.90	25.60	23.80	hmmbuild  -o /dev/null HMM SEED	198	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.28	0.71	-4.78	3	25	2012-06-28 12:22:48	2012-06-28 13:22:48	1	2	21	0	12	21	0	172.70	63	95.11	NEW	ASTLRYCMTVSGTVVLVAGTLCFAWWSEGDAusQPGQLAPPTEaPlPEuPsPLLRSVSFlCCGAGGLLLLlGLLWSIKsST+GPPRtDPYHLSRDLYYLTVESSEKESYRsPKVsAIPTYEEAVsCPLAEGPPTPPAQPsEEuLEs+AScDALLGoQss.PPPSYESIlLAtsAVSGpTs..PSPGpSCsGLlQsARGGs	.ASTLRYCMTVSGTVlLVAGTLCFAWWSEGDA......usQPGQhA...P....P.TtaPlPEuPusLLRSVSFhCCGAGGLLLLhGLLWSlKASopGPPRWD.YHLSRDLYYLTVEoSEKESCRoPKlssIPTYEEAVsh..PlA..EGP.PTPPAhPhEEsLcsSA.....stDALL...........uTQsshPPPSYESI.hAhsulSuETs...usstoCsG.sphstGG.......	0	1	1	4
+14957	PF15106	TMEM156		TMEM156 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N614	Family	The function of this family of transmembrane proteins, TMEM 156, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins are found in eukaryotes. Proteins in this family are approximately 310 amino acids in length. In humans, the gene encoding this protein is located in the chromosomal position, 4p14.	27.00	27.00	61.40	61.10	18.90	18.90	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.47	0.70	-5.12	6	34	2012-06-28 12:23:08	2012-06-28 13:23:08	1	1	28	0	19	29	0	213.80	56	78.32	NEW	EVCLQsNFTaSLsSlNFSFVTFLQPl+ETQTI.MGIFLNHSNFQNFTcICQsITuEhKhCSsCLsCESKGshDFISQEQTS...KVLlMRGShEVKusDFHSPCQHFNFTsAPhsDcLEEYNhTCpLKTHssRSsIhEE-Ps+EpSlN+TC..RhMEp.NNChpISL+LEMDVKNssCSMKITWYlLVLLVFIhhlIllI+KILEuHRRVQKWQSHKYKPTSsLLRGuDSEK	..EVCLpsNhTYSLsSlNaSFVTFLQPlRETQsI.htIFLNHSNFQNFTRICQsITuEhKhCSpCLlCESKGshDFISQEQTS.................KVLIh+GShEVKAsDFpSPCpHFNFTVAPhVDcLEEYNsTCpLKsHTt+SslhE--Ps+cpSlN+TC..RhMEh.NsCh+ISLHLEMDlKNhoCSMKITWYlLVLLVFlFLlILhI+KILEuHRRlQKWQ..S..H+.+sTS.sLLRGpDSEK..................	0	1	1	3
+14958	PF15107	FAM216B		FAM216B protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N7L0	Family	The function of this family of proteins, FAM216B, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins are found in eukaryotes. Proteins in this family are approximately 150 amino acids in length. In humans, the gene encoding this protein is located in the position, C13orf30.	27.00	27.00	35.30	35.70	25.80	24.70	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.61	0.71	-10.51	0.71	-4.20	6	56	2012-06-28 12:23:32	2012-06-28 13:23:32	1	2	26	0	25	61	0	106.40	50	55.52	NEW	Mspchp+.QcLhNlP+IPpI+VPpShsDTSLLK..DLTQGQpRYhYSIMRIYNSRPQWcALQsRYlHSLQHQ.QhLGYITQ+EAhusAhVLRcST+RASApsuP....Rol.pRssuho	..........hsppht+.QcLWpsPQ..pI+lPpShh..DsShhK..DLTpGQpRYhhSIh+IYNup..hphhpppYhHsLQHp.Q+...G.........hlTp+cuhhs.......o+huptphhP....Rp..c+psuh.......................	0	2	2	3
+14959	PF15108	TMEM37		Voltage-dependent calcium channel gamma-like subunit protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8WXS4	Family	This family of transmembrane proteins, TMEM37, has a role in stabilising the calcium channel in an inactivated (closed) state. It is a subunit of the L-type calcium channels. This family of proteins are found in eukaryotes. Proteins in this family are approximately 210 amino acids in length.	27.00	27.00	123.00	122.80	25.00	24.60	hmmbuild  -o /dev/null HMM SEED	184	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.32	0.71	-11.36	0.71	-4.59	6	38	2012-06-28 12:23:58	2012-06-28 13:23:58	1	1	31	0	23	39	0	179.50	68	93.16	NEW	QAQRLLupRRPp+uFFESFIRuLIILCsuLAVVLSSISICDGHWLLAcD+LFGLWaFCTsSNp...........ousHClRDLSpApVPGLAsGMlLARShuoLAVVsAIFGLELLhVSQVCEDhcSR+KWAhGSsLLLlSFlLSuGGLLSFlILL+splTLhGFTLMFWCEFTASFLFFLNuISGL......HINSlTpP	..........QAQR.LuQR+PpRSFFESFIRoLIIlCsALAVVLSSlSICDGHWLLA.ED+LFGLWHFCTsoNp...........osspChRDLupApVPGLAVGMuLsRSlGALAVVAAIFGLELLMVSQVCEDtHSRRKWuhGSlLLLlSFlLSSGGLLoFVILL+NQVTLlGFTLMFWCEFTASFLFFLNAISGLHINSITpP.......	0	1	3	7
+14960	PF15109	TMEM125		TMEM125 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q96AQ2	Family	The function of this family of transmembrane proteins, TMEM125, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 55 and 232 amino acids in length.	27.00	27.00	30.80	63.40	22.50	20.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.54	0.71	-3.96	6	45	2012-06-28 12:24:17	2012-06-28 13:24:17	1	1	33	0	25	36	0	109.40	73	53.85	NEW	slLEEQVELWWFp-P++SLLCYssuVsLILuCGhGGVGLLSTToShSGE...WRLusGTsLCLLALsVLLKQLLSSAVQDMNClRsR+RI-hLKSGGhuDsLllLloGLsLLlCG	.slLsEQVELWWSQpPRRShLCFsVAVuLVsGCGAGGVuLLSoTSSRSGE...WRLAsGTsLCLLALLVLlK.QLhSSAVQDMNCIRpt+HVuLLRSGGGADsLVVLlSGLVLLVsG	0	1	4	11
+14961	PF15110	TMEM141		TMEM141 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q96I45	Family	The function of this family of transmembrane proteins, TMEM141, has not, as yet, been determined. Members of this family remain uncharacterised. TMEM141 protein family is found in eukaryotes. Proteins in this family are typically between 103 and 124 amino acids in length. There are two completely conserved residues (C and W) that may be functionally important.	27.00	27.00	27.00	34.80	20.00	26.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-10.16	0.72	-3.70	12	53	2012-06-28 12:24:45	2012-06-28 13:24:45	1	1	44	1	29	54	0	88.90	47	74.94	NEW	ssI..p+lc-t.tsKHPGhspYhs......C.o+AhhpGluTFsLGhuusahlQ+hlp++lPYPhpaNlLVSslsuoVsSYpVTphcTppCpshWhhhEstp	............l..p+lcDt.tsKHPGhtpYhs......C.S+AhhcGlhTFlh.GouusFhlQhhlp+KhPYPhQWslLVusls..uSluSYtVTpsEop+CsslWlaLEsG.p..........	0	7	10	17
+14962	PF15111	TMEM101		TMEM101 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q96IK0	Family	The function of this family of transmembrane proteins, TMEM101, has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 257 amino acids in length.	27.00	27.00	37.30	30.80	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.54	0.70	-5.08	7	47	2012-06-28 12:25:10	2012-06-28 13:25:10	1	1	42	0	29	47	0	235.60	71	95.47	NEW	ssR+phLphhsplGsFllTRaPFWpsFshLMhaAERA-s++hP.....DltlP...al.YlDLusAVlCASFMSFslKRRWFAlusAlQLs.ISshhuhhutpshYu-WLKVRhaSRslAlIGGaLhluSGsGEhYRp.KPRoRSLQpTGplFLGlYLIC.AYsL.aS+EDRhAaLpHIPGGp.hl.lhhVlaslLuLuaLSGa.hphhuplLAllLshshLllDGslsYWa+o+.+VEFWsQh+LlucNluIFGAllIL..AsDu	.......u..R+hhLpLlhQlGuhLLTRhPFWsCFS.LMLaAERA-u+RKP.....DIPVP...YL.YF.DMGAAVLCASFMSFGVKRR.W.FALGAALQLA.lSTYAAYlGGaVHYGDWLKVRMYSRTlAIIGGFLVLAS..GAGELYR+.KPRSRSLQSTGQVFLGIYLICVAYSLQHSKEDRLAYLNHLPGGELMlQLaFVLYGVLALAFLSGYYVsLAAQILAVLLPsVhLLIDGNluYWHsTR.RVEFWNQMKLlGEsVGIFGAAVIL..ATDG.........................	0	7	9	13
+14963	PF15112	DUF4559		Domain of unknown function (DUF4559)	Bateman A	agb	Jackhmmer:Q8TB03	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes human protein CXorf38.	27.00	27.00	65.20	27.60	25.40	23.40	hmmbuild  -o /dev/null HMM SEED	307	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.60	0.70	-11.92	0.70	-5.26	8	62	2012-06-28 12:25:15	2012-06-28 13:25:15	1	7	37	0	32	49	0	241.90	51	64.70	NEW	RhNstsYKNWLKsGpuLLlLRsuLQsFlt+EscsaHpuLpsKlss..ssppCp....Css+uRp.pstCplCc.W+cEIlpaHsscsucIHWsNCcPstW...ss-hWEVAKAFMPRGp.sD+sGPEcsDsSALLNFlstCcHFph...chcpVpcVIcVRNclMHSsDLKhSspshpcahsKIpphlp...hsslPslptstccIpplpss-apltssptspcDGsclpT-sh.shpclL-lEpctLcD+lpcLhsphEpsps.s.Echhpslpslh-FLpsNpDLppsLpscl.......sKLpplps+lpKh-tpls-l+sphsQL	..................RLNsspYKNWlKAGpCLLlLRssLpsFlspEshsFHptLlsthss......spssCpt..tCsP+u+phpspCpl...CtpW+pEILpHHhscsus...lpW.uNCcPshW...ss-...WEVA......KAaMPR..Gh..sc+pu..s-pCDAsALLshlstCc+Fhs...DtcpVpc.VIcsRNc.lMHSu-hKVSstWhp-at.+IpsFLs..pFpplP-lssshp+IEplLssDaslahsttDphD.....Ghch-htshls.pp....lp..-lEhphL+E+LpEhhhphccpphhs..Ec..pplpsltpFLcpNcDLppsLpt-h.......pKLpsh..p.phtp...............t...................................................	0	6	9	16
+14964	PF15113	TMEM117		TMEM117 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H0C3	Family	The function of this family of transmembrane proteins has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 504 amino acids in length.	27.00	27.00	32.60	32.60	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	415	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.54	0.70	-5.88	4	63	2012-06-28 12:25:37	2012-06-28 13:25:37	1	2	39	0	38	51	0	317.70	70	79.75	NEW	t+DFRYYFQHPauRLhVAYLVlFhNFLlFAEDPVSHSpTEAplIVVGNsFSFlssKYP.GhGWplLKVlhWLLAllhGLlsGKFlhH+hLFGpLLRLKMFREDpGSWMhMFhoTllFLFIFSpIYNhhLLhAGs..tsahIoDhMGIRNpSFMKhAAlGTWMGDFVTAWMVTDMMLQDp.YPsWA+usRtFW+p.GpsRIILFWoVLloLToVVVhVIoTDaISWDhLNRGFLPosElSRAFLASFILVhDLLIVMQDW-FPHFMGDLDlpLPGhpTsHh+h+lPhppplaK-EapIHITGKWFNYGIIhLVlILDLNMWKNQIFY+Pa-YGQYlGPssKIaTVc-.-oLts..hNRTpLTa-WRuNphsPcTNcoYlEcDhahHSRYlGhoLsVKsLAFlPSLhAFVhFGhhIWhaGR	..........................s..cFRYYFQHPWSRhllAYLVhFhNFLIFAEDPlSHSQTEAphhVVGNCFS..FlhsKYP.uhGWthLKVlhWl....LAIlhGLlAGKFlFHp...pLFGph....lRLKMFpED.cGSWMsMFhSsllhLFhFSplYNhhLlhtGs.htsahlsphMGIcNpsFMK..hAAlGTWhGDFlTAW.M.VTDMMLQDp.......YPDWG+uAR.....tFWK+..Gp.RIhLFWoVLhoLTSVVVLVIoTDWISWD+L.......NRG.....FL...PSDEVSRAFLASFILVFDLLIVMQ.DWEFPHFMGDlDl.NLPGLpTsHhpF+lPhhp+IFKEEY+IHITGKWFNYGIIFLVLILDLNMWK.NQIFYKPaEYGQYlGPGp.KIYTVcDsEoL+D..hNRTpLSWEWRSNpTNPpTN+TYsEuDMFLHSRahGuSLDVKCLAFlPSLlAFVhFGFFIWFFGR.................	0	8	12	19
+14965	PF15114	UPF0640		Uncharacterised protein family UPF0640	Bateman A	agb	Jackhmmer:Q8WVI0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 70 and 80 amino acids in length. There are two conserved sequence motifs: PGK and YRFLP.	27.00	27.00	66.50	66.40	26.60	25.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.37	0.72	-4.50	10	56	2012-06-28 12:25:59	2012-06-28 13:25:59	1	1	50	0	38	56	0	68.10	56	89.06	NEW	Mhh.+..Spsl+plLcpWPGK+phGlYRFLPlFFsLGAuhEasMINhRlGcpsFYcsY+R+QAE+hhEp+hcp	.................h..ptpl+RlLpphPGKpRFGlYRFLPhFFVLGushEWhMIplR.V.Gc.EoFYcsY+R+puEc.hpc+lcp......	0	7	11	22
+14966	PF15115	HDNR		Domain of unknown function with conserved HDNR motif	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VZQ5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 219 amino acids in length. There is a conserved HDNR sequence motif. The function is not known.	27.00	27.00	35.40	35.30	20.10	19.30	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.34	0.71	-4.34	6	73	2012-06-28 12:27:26	2012-06-28 13:27:26	1	2	36	0	47	64	0	150.10	36	84.54	NEW	Ms+uhh..ssssctcGpWFsphh........cuHhsoph+psas..apc...pscspsPshFtpRpKpssspph........FShHDNRHoFpspGs...YFssGLGK++hs.sp.....p+t+.SpNhhpWss..hsuspDs..hSoYpsuaht.......cpss.ssthRphPRhhscp.puuphtssppsspa..hsppPcs.........chslstpsp	.......................shsGpW.asphh.........puhh..puphKp.psschpp...pscsp.PslathRpKpsssppF.........FShHDNRaSapssGh...Y.L.spGlG.RKpl........p+.t.p+sF.hWAss...l..p.p.t...Ss.Qhsah.......................................................................s.................................................	0	11	12	17
+14967	PF15116	CD52		CAMPATH-1 antigen	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P31358	Family	\N	27.00	27.00	40.70	40.10	19.80	17.90	hmmbuild  -o /dev/null HMM SEED	44	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.91	0.72	-8.08	0.72	-4.15	4	22	2012-06-28 12:27:31	2012-06-28 13:27:31	1	1	17	0	8	20	0	44.90	48	65.52	NEW	LGpsTTut.sop...........+SussAhusLuGGShLFFlANTLIpLFYLS	................GpssTot.........................pSussA.SsluGGsFLFFlANslIpLFhhS	0	1	1	1
+14968	PF15117	UPF0697		Uncharacterised protein family UPF0697   	Eberhardt RY, Coggill P, Hetherington K, Bateman A	agb	Jackhmmer:Q96E16	Family	This family of uncharacterised proteins is found in vertebrates. Proteins in this family are typically around 100 amino acids in length.	27.00	27.00	61.40	61.30	19.90	19.60	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.29	0.72	-4.23	4	50	2012-06-28 12:28:25	2012-06-28 13:28:25	1	1	39	0	30	41	0	93.30	77	93.22	NEW	uDsGoIDYSVHEAWNEATNVYLlVILVShuLhMYAR+NKRKIMRIFTlPPTAEossEsNFYDohpKIRLRQQLEMYSIARKa-.Q..Q...tQsDSVQLSlE	....uDDGSIDYoVHEAWNEATNVYLlVILVSFGLFMYAKRNKR+IMRIFSVPPTtETLS...EPNFYDTlSKIRLRQQLEMYSISRKYDhQ.QPQ...sQuDSVQLSlE..........	0	2	4	12
+14969	PF15118	DUF4560		Domain of unknown function (DUF4560)	Bateman A	agb	Jackhmmer:Q96HG1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 66 and 78 amino acids in length. There are two conserved sequence motifs: FCK and RTL.	27.00	27.00	74.90	74.70	22.60	22.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.61	0.72	-8.99	0.72	-4.17	5	46	2012-06-28 12:30:52	2012-06-28 13:30:52	1	1	23	0	30	64	0	62.80	76	75.50	NEW	AsALSGLAVRLuRoAAsRuSYGVFCKGLTRTLLsFFDLAWRLRMNFPYFYIlASVILNVRLQV+I	........AAALSGLAVRLSRSAAsRuSYGsFCKGLTRTLLsFFDLAWRLRhNFPYFYIlASVMLNVRLQVhI..	0	1	1	4
+14970	PF15119	APOC4		Apolipoprotein C4	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P55056	Family	\N	27.00	27.00	58.70	58.60	24.60	19.40	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.27	0.72	-4.02	6	27	2012-06-28 12:31:28	2012-06-28 13:31:28	1	1	21	0	14	24	0	92.60	62	78.88	NEW	CQ.t.sEto.SPsPtPcpS+.WSLVPu+VKEhVpPLVTRTRE+WQWFW..GPuAFQGFhQTYYDDHL+DLGsRT+AWLpSSKDsLLNKAHSLCPRLlCGD+D	.....................................h.pto.SPsPt.c.Sp.WSLVpu+hKEhlEslVsRTR-pWQWFW..uPusFpGFhQTYY-DHL+DLGPRT+AWLhpSKDSLLNKTHSLCPRLlCGD+D..	0	1	1	2
+14971	PF15120	DUF4561		Domain of unknown function (DUF4561)	Bateman A	agb	Jackhmmer:Q96E40	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	34.30	33.30	24.10	21.00	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-10.90	0.71	-4.79	6	65	2012-06-28 12:32:32	2012-06-28 13:32:32	1	3	39	0	34	54	0	160.90	60	76.91	NEW	MsEl+cpL+hlpQ+YKLFpQQQFTFlsALERsREsAaD+hcPVuoIsQVQpYh-HaCsNuTDRRILhLFLDICsDLsshpp+lEsLp......SssssosphL-pC+sLls.SNDlSslRA+YPHDVVNHLSCDEARNaYGGVVSLIPllLDhlpEhht..psc+Lt.tpp.ssstppp	................MNEVKEsLRslEQ+YKLFQQQQFTFIAALEHCRENA..HD...KIRP.ISSIuQVQsYMEH....aC.....NNSTDR.....RILlMFLDICoELs+LCQ+FEuLH................SGTPVTNsLLEKCKoLVSpSNDLSoLRA...KYPHDVVNHLSCD........EARNHYGGVVSLIPllLDlhKEWIA..+oEKLPp...........th...t.........	0	8	10	18
+14972	PF15121	TMEM71		TMEM71 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6P5X7	Family	The function of this family, TMEM71, is not known, however it is predicted to be a transmembrane protein. This family of proteins is found in eukaryotes and located in the cell membrane. Proteins in this family vary between 41 and 291 amino acids in length.	27.00	27.00	27.00	39.90	26.90	26.10	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.98	0.71	-4.47	10	47	2012-06-28 12:32:51	2012-06-28 13:32:51	1	1	32	0	21	39	0	131.30	62	55.16	NEW	MY..phStlhSTPVussopp-tththp.SPsslhsSasCD.LD......GDSSFECsSlDPLTGShasCRRSPRLLTNGYYlWTEDSFLCDcDGNITLoPSQTSVhYKENLVRIFR+K+Rh+RSLuSLhS..hpAScSWL+GSIFscV................sSsPSEDsWLEGsRp	............MYRlopLMSTPlASpst....pt..tphosp.plhsS.FsCD.LD......GDpSFECsSlDPLTGSaasCRRSPRLLTNGYYlWTEDSFLCDcDGNITLsPSQTSVhYKENLVRIFR++++hp+shuSLFs..lssScSWL+uoIFscl................cS.s.sEDsWL-Gh+p......	0	1	3	6
+14973	PF15122	TMEM206		TMEM206 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H813	Family	The function of this family of transmembrane proteins, TMEM206, has not, as yet, been determined. Members of this family are remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are approximately 350 amino acids in length.	27.00	27.00	149.50	149.10	19.20	16.40	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-11.82	0.70	-5.51	3	51	2012-06-28 12:34:56	2012-06-28 13:34:56	1	2	39	0	31	44	0	287.80	75	84.57	NEW	PIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFRDKLKHPVMSVSYKEV-cYDAPGIALYPGKA+LLSCcHHaYDsIPPLsuPGQPG-RsCsTQ-IsYpcPYoN+TMK+ALIVQGPpDVR+RELVFLQF+LNETcEDFSAIDYLLFSSFc-FLcSsDKAuFMQDCESuYSSWKFSGGFRTWVKMSLVKTKEEDGpESVEFRQETSVVNYID+RPssE+osQLFFVVFEWKDPFIQcVQDIITANPWNTIALLCGVFLALFKAADFAKLSVKWMIKIRKRHLK+RuREhNHIS	..........SIRFSKACLKNVFSVLLIFIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEV.DRYDAPGIALYPGQAQLLSCKHH.Y-VIPPL..suPGQPGD....hsCTTQRINYTDPFSNQThKoALIVQGPpEVKKRELVFLQFRLNposEDFSAIDYLLFSSFQ..EFLp...S.........P-+sGFMQuCESAYSSWKFSGGFRTWVKMSL.VKTKEEDGREAVEFRQETSVVNYIDQRPAAE+SsQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRaLK+RuQAsNHIS.........	0	2	4	12
+14974	PF15123	DUF4562		Domain of unknown function (DUF4562)	Bateman A	agb	Jackhmmer:Q96LM5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. There is a conserved HRYQNPW sequence motif. This family includes the human protein C4orf45.	27.00	27.00	41.50	41.10	18.10	17.30	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.46	0.71	-4.21	9	43	2012-06-28 12:35:21	2012-06-28 13:35:21	1	1	30	0	24	42	0	109.70	47	59.28	NEW	lFTGPDhl+Dahs+lhpassYIG.tp.u.EtTuDLpYLWRPAsspshPhthKpchlGEIGWGIs.ashhs+p+Lpo....GhpIKhGEhppAs.D+hTHRYQNPW.Pt...P.hl-tpsthuR	....lFTGPDYl+DahPKlppaTsYlGEpp.uLEpTuDLcYLWRPAsspShPschKacYVGEIGWGlPpasalN+oRLpo....GFpIKhsEhppAu.DphoHRYQNPWQPpPplhDhpst.S.............................	0	10	11	13
+14975	PF15124	DUF4563		Domain of unknown function (DUF4563)	Bateman A	agb	Jackhmmer:Q96PS1	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes the human protein C3orf24.	27.00	27.00	120.30	27.30	19.00	18.70	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.23	0.71	-4.70	3	35	2012-06-28 12:37:45	2012-06-28 13:37:45	1	2	29	0	24	35	0	167.80	73	99.93	NEW	MAsYQLWSPWSPLDENLQWLRHTTPThuSKHPFRuSPsFPaTPuDVEVQtCFHEVslVpDpPhlcAG+SPcLPsHshEP+..ThsNhpupIRKPQPIRLlGVDSVFGRVITuQPPKWTGTFRVS-KSAFSKIIS+EpQWPpGLKEPQIEMTlsMCKQMLRSILLLYAIYKKCTFALQHSK	......MAGYQLWSPWTPLDESFQWLRHTTP...TPSS.KHPF..RASPCFPHTPSDLEVQLCFQEVTLVLDSPhLEsGhSP..KLPC........HTSELR..ThsspKGLVRKPQPVRLSGVDSVFGRVITAQPPKWTGTFRVSDKSAFCKIISREHQWPTGLKEPQIQMTVTMCKQMLRSILLLYATYKKCTFALQHSK...................	0	1	2	10
+14976	PF15125	TMEM238		TMEM238 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:C9JI98	Family	The function of this family of transmembrane proteins, TMEM238; has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 61 and 153 amino acids in length.	27.00	27.00	29.80	29.30	26.10	25.50	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.73	0.72	-9.25	0.72	-4.07	9	40	2012-06-28 12:38:05	2012-06-28 13:38:05	1	1	24	0	26	43	0	67.20	55	48.09	NEW	GRCphhhh.lAVlhDslGlslLLlGlFAsL.....sFaDhLlYoGALllhLSLlhWlhWYoGNIE..ls.cEL	....GRC+hhLh.LAVshDlsGhssLLsGVFApL.....sFhDhLlYoGALllFLSLLhWIhWYTGNIE..lohpEL.....	0	2	6	13
+14978	PF15127	DUF4565		Protein of unknown function (DUF4565)	Bateman A	agb	Jackhmmer:Q9BSF0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  This family includes the human protein C2orf88.	27.00	27.00	35.00	35.00	22.80	18.00	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.07	0.72	-3.65	5	31	2012-06-28 12:40:36	2012-06-28 13:40:36	1	1	29	0	18	24	0	91.00	58	99.30	NEW	MGCMKSKcphPhssThcu-K.....s+cuEEAa..tchh..........lsssEEs+cPsuPp..huPVLLEYAcRLSEEIVs+AVQQWAElDp+YuDIPYIESDuP	MGCMKSKQTFPFPTshEuEK.....pH-SEEsF.MPEE+hL.+....st.lslpEElKcP..suss....sVlLEYAHRLSQEILsDALQQWAssNlKYtDIPYIESEuP.	0	1	2	4
+14979	PF15128	T_cell_tran_alt		T-cell leukemia translocation-altered	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P57738	Family	This family of proteins is required for osteoclastogenesis [1].	27.00	27.00	43.00	32.50	20.20	24.70	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.41	0.72	-10.26	0.72	-4.54	4	48	2012-06-28 12:40:48	2012-06-28 13:40:48	1	2	35	0	24	42	0	84.70	61	85.78	NEW	opllsuh.uFhSEFlc-W.usDMRVoIFKlLLuWLVlSLlAIphAW+sYGNTVNshYYRQGhuGQNGGTPDsss+hsuWEpuus-sLKTHpE	.......splLsuLsuhuSEFlcEWEApDMRVoLFKLLLhWLVLSLLuIQLAWthYGsTVTGLYaRs................GhG.G..QNGuTPDsusHFsuWE.susEshKTHRE.....................	0	2	4	9
+14980	PF15129	FAM150		FAM150 family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6UX46	Family	This family of proteins known as FAM150 is found in eukaryotes. Members of this family are as yet uncharacterised. Proteins in this family are approximately 143 amino acids in length. The function of this family has not, as yet, been determined, however it is predicted to be a secretory protein family.	27.00	27.00	50.70	30.50	18.50	23.00	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.81	0.71	-4.24	6	65	2012-06-28 12:42:58	2012-06-28 13:42:58	1	1	30	0	34	58	0	92.10	66	77.03	NEW	-cpoLLcLIh-llp-hpppcpspspp....l..hupcspsss+ccsttlsshssEphlEIhPRDLpMKDKFlcHLT.GPLYFSPKCpKcFHRLYHNTRDCTIPAYYKRCARLLTRLAsSPhChE	.............................................................................................................................t.ppps..EIhPRDLphKDKFlKHLT..GPLaF.SPKCSKHFHRLYHNTRDCTlPAYYKRCARLLTRLAVSPhChp........	0	2	7	16
+14981	PF15130	DUF4566		Domain of unknown function (DUF4566)	Bateman A	agb	Jackhmmer:Q9GZU0	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes human protein C6orf62.	27.00	27.00	177.20	61.80	18.70	18.30	hmmbuild  -o /dev/null HMM SEED	241	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.68	0.70	-5.20	2	54	2012-06-28 12:43:17	2012-06-28 13:43:17	1	3	40	0	33	38	0	209.50	86	92.76	NEW	M.........uDP.oRKppslsRLRtpLR+K+ESLADpFDFKMYluFVFKDKKKpsALFEVs-VIPVMTNNYc-sIh+GV+-puYSLESS.ELLpKDVVQLHAP+YpsMR+DlIGCsQ.hDFhLWPRpDI-KIVChLFSRWKts.DtsaRPVQscFEFcHhDYEKQhLHlLuR+DpTGlllNNPoQShFLFlDRppLpTPpNKAshFKLsSlCLal.Q-QLhHWssGoI-chLc.YMP..p	................MGDPNSRKKQALNRLRAQLRKKKESLADQFDFKMYIAFVFKEKKKKSALFEVSEVIPVMTNNYEENILKGVRDSSYSLESSlELLQKDVVQLHAPRYQSMRRDVIG.CT...QEMDFILWPRNDIEKIVCLLFSRWKtS.DEPFRPVQAKFEFHHGDYEKQFLHVLSRKDKTGIVVNNPNQSVFLFIDRQHLQTPKNKATIFKLCSICLYLPQEQLTHWAVGTIEDHLRPYMP...E.................	0	3	5	15
+14982	PF15131	DUF4567		Domain of unknown function (DUF4567)	Bateman A	agb	Jackhmmer:Q9BTX9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in some mammals.	27.00	27.00	37.50	115.50	19.90	19.50	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.22	0.72	-9.42	0.72	-3.84	4	11	2012-06-28 12:52:58	2012-06-28 13:52:58	1	1	11	0	6	2	0	75.90	76	84.43	NEW	pRLDEs.AsLRLQHaLQLtEGLAVPLPPLVVpuPAAHaVAGGuLuDFTLDIALGARRItLAhVRQVAQDGPVAFLA	.RRLDEsPAsLRLQHHLQLREGLAVPLPPLVlQSPAAHHVAGGShuDFTLDIALGARRVRLALVRQVsQDGPVAFLA	0	1	1	1
+14983	PF15132	DUF4568		Domain of unknown function (DUF4568)	Bateman A	agb	Jackhmmer:Q9H693	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	51.10	51.00	21.10	19.40	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.80	0.70	-11.71	0.70	-5.13	4	25	2012-06-28 12:54:36	2012-06-28 13:54:36	1	1	20	0	13	23	0	132.50	44	81.24	NEW	GsGh.psWha.......GRs+h+sLschChu+hss.VspTVHpEsICCECpsKFGGaLPVPRA-AsLPYWVPLSLRPpKQIQKMVRhYIPKooKAC.CPCHpFGGRLPMPRDQAVMPYWVPQVLRSpKKVVKRQQshcslPEsslDlRShYspWRICG-G+hLLKWQQLQALHQsc..PlAsGpPtSh.AsLLPlshSLLTLLQAlLRVllAIRpLFWs	...................................................................................slCCECQs+FGGRLPVsRsEAALPYWVPLSLRPRKQh.+h..hph....................................................................................................................................................................................	0	1	1	2
+14984	PF15133	DUF4569		Domain of unknown function (DUF4569)	Bateman A	agb	Jackhmmer:Q9HAI6	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  This family includes human protein CXorf21.	27.00	27.00	38.20	36.40	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-11.96	0.70	-5.03	8	57	2012-06-28 12:56:17	2012-06-28 13:56:17	1	1	36	0	37	43	0	279.10	45	97.54	NEW	MLuEGaLopLsYpsphcts....hpopsppsspppthcpp.ssh...shushDcsphcslhsuscsstch.uuVHspts.ps.p....tphlpsspsPshpussSsulcIPccs.cps.thaLVPS.SC..cSICpNYsDLHIuGDpVhslsssuGsh..ssssshpcGPlLhSsDIP.uhpsphps.sp.h....h.pshSShW+ssps+E+.ShL.ppc..PlSNSlLNsYLEpKlhELYKQYlhEsss+suSs........splLuSELlMTNVDQISlQlSREpNlEToKA+DhlLssL....LplsSph.pSEISTPsLpISs.us	................MLuEuaL.slhYhpphahs....hsshsppsstcct.cpp.ht....ohSSs-csp.cshhhpspossch.oolpsptsppshp..pphsslpss..ssshpuss.sAlpIs+csp+-p...aLVPs.SC..cSIC+NYsDL+IAGspVhshsssossF...scsshp.GPLLpSs-IPLshEsulssp.s.h..hsh.pphSShW+hsSI+EK.S.L.hpp..PlSNulLNcYLEpKVsELYKQYlh-slh+suSs........TplLASELlMosVDQISLQlSpEpNlEsoKA+DhVlspL....LphsS....oElSTPsLpISp.o..........	0	1	4	11
+14985	PF15134	DUF4570		Domain of unknown function (DUF4570)	Bateman A	agb	Jackhmmer:Q9HBI5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. 	27.00	27.00	29.00	28.70	24.00	23.70	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.80	0.72	-10.43	0.72	-4.21	9	41	2012-06-28 12:59:01	2012-06-28 13:59:01	1	1	37	0	28	40	0	107.30	54	85.97	NEW	MsS.hsp........El+Luc+HEEILupRthLLppMEs+hpspppc+ppphpsspsAppRNtpLLpDl-ssEcpLpsR...hscPslluLETpYWASVEc......lPtWEpaLLuRu.hPhu	.............MoShasQ........El+LSKRHEEIlSQRLMLLQQMEs.+huDQpsE...KA.SQhQusEsAa+RNhoLLpDIEAAEKSL..QoRhaslPpP.ElVoLETpYWASVEEa.....lPKWEQFLLGRAsYPh.u.....................	0	5	7	11
+14986	PF15135	UPF0515		Uncharacterised protein UPF0515	Bateman A	agb	Jackhmmer:Q9NUL5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There are two conserved sequence motifs: PLT and HSC.	27.00	27.00	39.80	39.80	25.90	25.40	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.11	0.70	-5.33	4	53	2012-06-28 13:38:07	2012-06-28 14:38:07	1	2	34	0	27	52	0	227.20	68	88.44	NEW	REKFHG+lu.csAssLMRRasssHptVut.lshhscscssl-hpsphcLpssP.uh.V..thht--.ptpt..t......................D+DIpslA.p+hshLPLTpcNl+MFscAptshIPu.s+QFACcuCDhhWWRRVPQRKcVSRC++C+K+aDPVP.ss+MWGluEFpCspC++pF+Ga.uphsspSPCYGCppsl....YPh+ILPPR..Rs....ss.+opNpHSChAE.CYpRhEPaVPGspCsHP+SRptNphPKVlaPS.hHISoGSTluTCLSQGSL.E.-lspLIL-Dl	..........REKFHGKV.osc+AssLMR+FuSDHTGVGRSIVYsVKQcDGQ-LSNsLDAQDPP...........EDhKQ................................DpDIQAVA...TSLLPLTcsNLRMFQRA.Q-DLIPAVDRQFACSSC.DHVWWR..RVPQRKE.VSRCRKCRKRY-PVP.sDKMWGlAEFHCPKCRHNFR....Ga.AQMGosSPCYGCGaPV....aPTRILP.PRhDR-....scRRSsHTHSCS.AtDCYNRREPHVPGTSCAHPKSR+QNHLPKVLHPSssHISSGSTVATCLSQGuLlE.DLDsLILEDL............................	0	4	7	11
+14987	PF15136	UPF0449		Uncharacterised protein family UPF0449	Bateman A	agb	Jackhmmer:Q9UFG5	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes.  There is a conserved LPTRP sequence motif.	27.00	27.00	27.40	28.20	24.40	26.90	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.45	0.72	-10.27	0.72	-3.78	9	48	2012-06-28 13:41:22	2012-06-28 14:41:22	1	2	39	0	29	50	0	89.30	47	80.26	NEW	uKKRsVLPTRPsPPoVEQILEDVcsA.usDPVFpsL....sss.s.pstss-uptEph.............Y.QSRpYlshNpRLppAtssLcp+p-pL+pAGEcLEp-lspV	.......KKRVlLPTRPsPPTVEQILEDV+uAsscDPVFThL..........cssss....t...p...tcss..-uttEph..........................................YQQS+sYlshNpRLppAt..s.Lpp+p-tLptsGppLcppl.p.................	0	5	8	16
+14988	PF15137	DUF4571		Domain of unknown function (DUF4571)	Bateman A	agb	Jackhmmer:Q9NYP8	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in vertebrate. This family includes human protein C21orf62.	27.00	27.00	122.70	122.30	25.50	24.90	hmmbuild  -o /dev/null HMM SEED	219	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.52	0.70	-11.34	0.70	-4.91	6	34	2012-06-28 13:43:34	2012-06-28 14:43:34	1	1	27	0	20	29	0	213.10	65	94.93	NEW	MAPPSuHsLLLhuALGlFALssFTcGQ+NSTLIFTKENTIRNCSCSADIRDCDYSLANLMCSCKTVLPLAlEpTSYsG+LTIWFTDTSALGhLLNFTLVpDLKLSLCGTNTLPTEYLAICGLKRLRlsTEAKHPSsEQSLLIHsGGEucsREKsh.La+GWQTChYISFLDMALFNR-SuLKSYSIENluSlAssFPsFSYFcTFPl.oNKSYVVTFIY	........Ms.P.tasLLLhusLGlFALssFT+GQKNSTLIFTKE.NTIRNCSCSADI..RDCDYSLANLMCoCKTVLPhAl....E+TSYs..G+LTIWFTDTSsLGpLLNFTLVQDLKLSLCuTNTLPTEYLAICGL+RLRIssEA.KpsaPEQSLLIHSuu-o-sc-cshhLpKGWQsChYISFLDhALFNR-SuLKSYSIEN..VoSIANsFPsFSYF+oFPhsSNKSYVVTFIY.....	0	1	2	6
+14989	PF15138	Syncollin		Syncollin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VAF6	Family	This family has a role in zymogen granule exocytosis [1-2].	27.00	27.00	27.90	27.60	26.40	26.00	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.59	0.71	-4.17	6	27	2012-06-28 13:46:15	2012-06-28 14:46:15	1	1	23	0	17	28	2	110.00	61	83.22	NEW	ACPsPA-LKs-sGo+hCARhaE+SssYYDpsCGGu.LsVcPGsDhPYhPSsWsNpISSLVVupRCpLTVWSppGKpGssRKFSAGoh.+LcEY++GlFGsWscSIuuhYCpC	........ACPssA.DLKcsDGTRsCA+LY-KSDPYY-NCCsGApLSlEPGsDLPYLPSsWsNssSSLVVusRCELTVWSppGKuGKT+KFSAGoYPRLEEYR+GIFGsWuNuISulYC+C..	0	2	5	9
+14990	PF15139	DUF4572		Domain of unknown function (DUF4572)	Bateman A	agb	Jackhmmer:Q5VTT2	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 220 amino acids in length.	27.00	27.00	36.50	35.80	25.50	24.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.43	0.71	-4.48	10	47	2012-06-28 13:47:15	2012-06-28 14:47:15	1	3	40	0	31	48	0	169.10	43	81.23	NEW	ERKGSLsL+Ss+hcYSsssLlpsWHpsREAcPKDYDlcshsstKpNLHpSTY+RlG..oDcsshslSpT+-thuQ.Vhlpc-apchh....++uhlchpo...hspshlE+Ds-tssouhcslhhc......psschcp.cYcTThppDYpsPYPYp....PssssP...sshslspRKh+spFsDL-up+RhGhspWpD-s.....tlht.pts+pclYcsp	........ERKGSLhLRSp+hpYSpssLs.sWHpsREA.PKsYDlcs.s...ts+pLppSTYpRlG..TDcsshhhSET+-phuQ.lhLpp-atchc....p+sLLs.-T...hspullERs.suhPtoGFGulhsR......HPP-hpKhph.TThppDYssPYsY......s.s.P...tsaSlsaRKCpSQFsDlss..+RhGhpoWpD-s.....tlhs.p.h+tpla...s........	0	10	11	19
+14991	PF15140	DUF4573		Domain of unknown function (DUF4573)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6P6B1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.	28.20	28.20	28.40	28.70	27.80	28.10	hmmbuild  -o /dev/null HMM SEED	174	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.87	0.71	-11.32	0.71	-4.66	10	82	2012-06-28 13:48:36	2012-06-28 14:48:36	1	15	39	0	62	80	12	137.60	21	37.03	NEW	AsDPstsTccTpPLcGlpEs-PPQPuGKDDs.sspppK+DlcAlTEspPLKGsAEsEPltstschpPLRssuEpDustAVcshEsPQsAuEMKPLpTAEpI.PLEuApEhpPpEAsGKscQsQlsEslPKEssSPEI..LEGSQ.lEsucppQLpEsLGcsEQsQsLEsVPKENto	....................................hps..s..t.ts.ps.tt.ps.t.s.tthcsspssopspPlpssspscPhts.sphpPlpsssphcshpslpss.csspsssp...hcPhpsspplpP....lpsspphpP.pshstsc.sp.hp.h.....................................................................................................	0	34	39	43
+14992	PF15141	DUF4574		Domain of unknown function (DUF4574)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6UW78	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between  and 86 amino acids in length.	27.00	27.00	29.40	28.70	26.00	25.20	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.89	0.72	-9.81	0.72	-4.25	11	54	2012-06-28 13:51:19	2012-06-28 14:51:19	1	2	48	0	30	53	0	82.10	39	95.11	NEW	MsulRplLhusullGhG.GlGYulaslloPGEERKpEMLKshPEusPhRh-EscKpstLlhpsLcEAApTsENlAR....hhGu.t.......ppp	...............MtuhRhhh.slsllGhG.GlGhuLhsLloPGEcpKp-hLKphPppsPtpp-Est+pptLhhtsLQEAAsTpENlsh......h.s......stt.........	0	4	7	13
+14993	PF15142	INCA1		INCA1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VD86	Family	This family of proteins inhibits cyclin-dependent kinase activity [1-2].	27.00	27.00	37.60	36.90	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.32	0.71	-4.48	6	29	2012-06-28 13:54:22	2012-06-28 14:54:22	1	2	21	0	12	36	0	149.10	70	64.37	NEW	Phs+CSRVVSRSsPPuLPSQSLtLMPQ+YGDlFWENLSQRPoPTWhEEQYsPPLLRATGCSQPGLYPPEGLPPPEhLCRRKRRRPpLuGM.QQGsGuIPARVRAVTYHLEDLRRRQRIINELKKAQWGSSGAAsEPLsLsE-GCthPSTocY...DlEEERAsYPQEEs+hLTsGRsQLLW	Phh+CSRVVSRSsPspLPSQshR.MPQpYGDlFWcNLSQRsSssWhEEQaIPPhL..RATsCSp.uLa.P.EtLPPPEhLhRRK+RRPpLttM.QQG.GulPARVRAVTYHLEDLRRRQpIINELKKAQWGSSGAAsEPlslsE-GCthsSTscY...DLEEERAsYPQEEsphLTPGRsQLLW....	0	1	1	2
+14994	PF15143	DUF4575		Domain of unknown function (DUF4575)	Bateman A	pcc	Jackhmmer:Q6ZSN1	Family	This family of uncharacterised proteins is found in eukaryotes.	27.00	27.00	148.00	38.40	20.30	18.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.94	0.71	-4.42	4	8	2012-06-28 13:55:04	2012-06-28 14:55:04	1	1	1	0	2	14	0	73.10	36	95.59	NEW	spGGpcuhLSlPuShGVPPssAMGVLRARGspGAGSQS.PRsGs..P..........pctlhLS.PpLhGsAS..CDGuPKuQGGKRuWhSV.sSR...........................GVPPPsAhGVLtARGGRG.AGSpSLPRGsshP.hch	.............................................................ttctlhlS.shL.......s.Gs.+spGsptsh.ph.sStGlPPPsAhGVLtARGtcG.s.spp..............	0	2	2	2
+14995	PF15144	DUF4576		Domain of unknown function (DUF4576)	Bateman A	pcc	Jackhmmer:Q6UWT4	Family	This family of uncharacterised proteins is found in eukaryotes.	27.00	27.00	69.40	67.80	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-9.90	0.72	-4.36	5	24	2012-06-28 13:56:29	2012-06-28 14:56:29	1	1	19	0	13	22	0	83.00	70	99.75	NEW	MAVSVLRLTlVLGLLlLILTCQADDKPp-...KPD-KPDDSGKNPEP-FPKFLNLLGSEIIENAVEFILRSMTRSTGFMEaD...DKQGEHSoK	MAVSVLRLTlVLGLLlLILTCpADDpP.-.....+PD...cKPDDSuKsPcP-FPKFLsLLGTEIIENAVEFILRSMoRoouFhEht...sppsp+...........	0	1	1	1
+14996	PF15145	DUF4577		Domain of unknown function (DUF4577)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N8F7	Family	The function of this family of proteins, has not, as yet, been determined. Members of this family are as yet uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically 128 amino acids in length.	27.00	27.00	125.50	70.50	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.01	0.71	-10.44	0.71	-4.23	3	33	2012-06-28 14:01:31	2012-06-28 15:01:31	1	2	26	0	19	25	0	118.50	71	98.86	NEW	MTHsSQDAGSRGhPE-RKLYVVDSINDLNKLSLCPAGSQHLFPLQEKIPDsGTsPGNGuRGLFFMGLIlVLIVSLALVSFVIFLIVQTGNKMDDVSRRLTAEGKDIDDLKKINSMIVKRLNQLDAEQN	............MsHSSQDsGSpGl..pEDtKLYVVDSINDLN.KLNLCPAGSQHL..FPLE-K..lPshG...TN.SG...NG..S....+SLFFVGLlIVLIVSLALV.FVIFLIlQTGNKMDDVSRRLsAEGKDIDDLKKINsMIVKRLN...QLDuEQN....	0	1	1	2
+14997	PF15146	FANCAA		Fanconi anemia-associated 	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VG06	Family	This family of proteins plays a role in the Fanconi anemia-associated DNA damage response [1].	27.00	27.00	27.30	47.50	20.90	26.70	hmmbuild  -o /dev/null HMM SEED	435	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.70	0.70	-12.57	0.70	-5.58	6	50	2012-06-28 14:04:41	2012-06-28 15:04:41	1	2	34	0	23	52	0	384.00	58	57.07	NEW	supAGQ+IK-LLSuIGsVSERVS.LKKAVDQ+N+ALssLNpsMNVSsALLSuppGs+P........IuCTlosoWSpL.hpDsLhATClLENSSuFSL-pGWTLCIQVLsSspAL-h-SusSAhTYThPVDpLsPGs+REVTLPLusucsGsLDLPVTlSCsLaYSLREllGsuLsss-shcs...tp.s..lLP-Q-GlCLPLscpTVDMLQCLRFsuhssspstus..s.huPspDPVcTFL+ospssssp.uGsu.S.p.....spYhPPSsASI+VSuELL+uAL+.soaSulsLssATLpWLLAENAAssllpupsloSlpGhAPDGs-V+Lhl+EVuloDLsPAGPIQAlEIQVESSSLAshCRhHHAllpRlQsLVhEQAApGSusPDLRhQYLpQhpsNHEoLL+ElQoLRD+..LCsED-hS.psuTup+LLplY+pLRsPSLlLL	..............s.tpsGp+IK-LLSGIGslSERVShLKKAVDQRN+ALssLNEsMNVSCAL.....L...SS.tpGs+P........ISCTsoTsWSRL.hpDsLhATClLENuSsaSL-pGWTLCIQVLsSSpAL-hDussSAhTYTlPVDpLuPGs+REVTLPLGPuEsGsLDLPV.TVSCsLaYSLREVlGuAh.ssS-u.-ss.h.-csPsshLP-Q-GlCLPLScpTVDMLQCLRFPuLA.....ss.pspuP..u.huPspDPVsTFLcos+t...P..uups..uGPu.SLR..........AcaLPP..SVASI+VSAELLRAA..Lc.D........ucSG..l..........s.....LCCATL.pWLLAENAAlDll.......+A.....p.....uLSSlQGlAPDGs-V+LlV+...E.....VAhTD..LC....P..AGPIQAVEIQVESSSLAshCRsHHAVltRhQs.MVsEQ.AAQGSSsPDLRlQYL.RQIauNHEsLLREVQoLRDR..LCTED-uS.SsATAp+LLQVY+QLRpPSLlLL.............	0	2	4	10
+14998	PF15147	DUF4578		Domain of unknown function (DUF4578)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96A22	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 137 amino acids in length.	27.00	27.00	27.50	72.50	25.20	24.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.80	0.71	-3.76	4	27	2012-06-28 14:06:32	2012-06-28 15:06:32	1	2	21	0	13	26	0	116.80	67	94.04	NEW	MGNRLCCGGSWSCPSTFQ+KKKhGSpsRhTLphQp......p.ht.NsoKsH-Tpu+TYEQVLpQPuSQcRS.puLpSEESsLHYADIQVhppspPRShpEVKHLpLENATEYATLRFPQATPRYDSKNGTLV	.....MGNRlCCGGSWSCPSTFQ+KKKTGSQsR.pTL+..Q............QQlpQNusKG+-TpGHTYEpVLpQ.sSQcRS..GLhpE-SsLHYADIQVCS+spsR...EVKHlpLENATEYATLRFPQATPRYDSKNGTLV......	0	1	1	2
+14999	PF15148	Apolipo_F		Apolipoprotein F	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q13790	Family	\N	27.00	27.00	27.30	31.90	21.40	26.80	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.55	0.71	-11.38	0.71	-5.01	8	40	2012-06-28 14:12:08	2012-06-28 15:12:08	1	3	28	0	20	37	0	180.80	47	61.13	NEW	PloCQsLLspu..shsphAPLPcFLs.LALclsLEphGC.sEsa.LQLQLhchGGh-uTETLI+c......S++oscchulsslpuhLptLutpsssh+RscRSl.ssEsCcpEpc.sl+clAQL.......LPulshhhpLtTAlh.ATQpCoDcuhE+hc-suhcLshs..hp.AshshsspshlIupulpslh+ssVphlhpYaQ	.....................................PhoCQ.Lh.pu....sphAPLPcaLssLALcssLEcsGC.s-shsLQLQLh+.GGlsATpsLIpaLpt..LppuppspcpsSlcALsSALQLLAp...Ep.uspRspRSl.ssccC-sEcEQsVHsllpL.......LPuVGTaYNLGTALYYAoQNCssKA+ERGpDGAIDLGYDLLMsMsGhoGGPhGlsIoAuLKPAl+uGVppLIpYY..........................................................	0	1	3	4
+15000	PF15149	CATSPERB		Cation channel sperm-associated protein subunit beta protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H7T0	Family	The function of this family of transmembrane proteins, CATSPERB, has not, as yet, been determined. However, it is thought to play a role in sperm hyperactivation by associating with CATSPER1 [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 220 and 1107 amino acids in length.	27.00	27.00	182.50	52.80	25.30	21.70	hmmbuild  -o /dev/null HMM SEED	541	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.89	0.70	-12.77	0.70	-6.31	5	43	2012-06-28 14:14:55	2012-06-28 15:14:55	1	3	29	0	29	39	1	462.60	52	59.02	NEW	+FcsIHhGKVIHSSKTGpAYIRcVhpHcT.PKGFhoSVIAElIEPFGlEss+ESsCLsSsLpIsauGNlaYpLoLpSQsspupFcuTDlEKTVlIPGYSSFLITcIlDspTAlAlATMPpolssNLsFLpuSWFLYNF..GptsGRoWpItoKPCNYWl.QQDphDuhSLNlVKYIDlGNolsFphKVIPssKuhpThEIP....LloVlVGNPsLLEVKApGaFDss-NYhLsIaluuKshppGSTSLAlIlWEuSocCaVoTllPTlKSSCSYLRoMHHIPu+aIP.EDWISGVHKDSQGFNMIKTLPINYRPPSsMGIuIPLTDNFYHADPS+PIPRNtFHpSKcTGKYKQCANVooREcCNCTccQKFSHAVAFSDC+EKVaRFKFPVTQYPVuLEIaNER-+IolEoPYLVTlTEVNMRcNWcLKHoVPENVKKMKsYLEPlL+oPVYNPLGLNLSIKGSELFHFRVSVV.PGVTFC-LpEEFQIYVDEsPLPFPGHsLIAVATAVVLGGLIFIAFlFQL+NIHPl+shp+.I+sNssphSoool	................................pFpslHhGKhIp.tpoGpAhIcKlhpHsh.spGFhSSVlsEhhcPFslEphp-SsCLsSSL.I.s..psGsh.Y+LoLp.p..sh..pu.FpsoDIEKTVVlPGYSSFLITpIlDspNALAlATMPppsssNhTF.csoWFLYNF..Gp+sGRpWpIhs+PCNYWh.Qpc..-o.SLNllKYIDLGsohshphKlI..p.s+.uhphhclP....LLpVhVGNPsLLE.VcscuhFD-oDSYlhpIsssSKhLppGSTSlAhlhWpASscChVTThVPTLKSSCSYL+oMHHlPu.......phIP.EDWlS..Gl..H+DSpGFNhIKTLPlNYRPPSNMGIAIPLTDNFYHADPSKPhPRNhF.hSKco.GKaK.QCANhooRcECNCTpcQKhSaAVAFSDC+EKVPRFKFPloQYPluLcIhs.Ec.splPlc.....sPYLVTlTEVN.RpNWcLK.H.slP-sl++hKpalEshltssVYNP.GLNLSIpGSELFHFRVoVl.sGVTFCsLlEEFQ.IYVDEsPLPFPGHsLIAluTAVVLGGLIFhAFh.FQlpsIHP.hpshpphhhpp........h................	0	6	7	12
+15001	PF15150	PMAIP1		Phorbol-12-myristate-13-acetate-induced	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q13794	Family	This family carries a BH3 domain between residues 23 and 40.	27.00	27.00	27.50	33.80	25.10	24.30	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.37	0.72	-8.66	0.72	-4.20	3	17	2012-06-28 14:17:15	2012-06-28 15:17:15	1	2	13	4	9	25	0	50.50	67	80.49	NEW	MPGRKSRKSsQ..PuPTRV..PsDLEVECAIQLRRIGDKLNFRQKLLNLISKLFRLGT	......MPG+KARKsAQ...suPsRs...s-LE....VECAhQLRRhGDKLNFRQKLLNLIuKLFp.GT....	0	1	2	2
+15002	PF15151	RGCC		Response gene to complement 32 protein family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9H4X1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 130 amino acids in length. There is a conserved KLGDT sequence motif.	27.00	27.00	30.50	72.90	25.20	25.00	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-10.66	0.71	-3.68	7	49	2012-06-28 14:17:28	2012-06-28 15:17:28	1	2	36	0	28	52	0	124.20	66	97.60	NEW	M+Ssssp.tstshhh..................-.ts-Lu-lLpEF-sVlc-F.tSPhpppp.tY-cHLcphKRRoutSlSD.SGlsDSE.Su-o.htsShshS-EcLNososs..........TssKAKLGDTKELE-FIADLD+sLtp..M	.............................tstsshh..................ssstDLoDsLCEFDAVltDF.uSPhccRHF+Y-EHLE+MKRRSSASVSDu.SGFSDSE.SADSLYRNSFSFSDEKLNSPTsSoPuh..oPssoPpKAKLGDTKELEDFIADLD+TLAS.............	0	1	5	13
+15003	PF15152	Kisspeptin		Kisspeptin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q15726	Family	\N	27.00	27.00	29.80	29.20	20.50	19.40	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.15	0.72	-9.84	0.72	-3.29	10	51	2012-06-28 14:20:42	2012-06-28 15:20:42	1	2	34	0	12	56	0	74.40	49	58.57	NEW	ssh.puLRss-p+Pss..Ap.ss+hou.s..scS.usGtphsuhshspSRlIPuPpGtlLVpREKDlSuYNWNSFGLRYG	....sWppu.pCsE+KPss..At.psRtsu.ssPsES.SuG.ppsuhs..uspSR.IPAPpGAlLVQREKDLSsYNWNSFGLRYG	0	1	2	5
+15004	PF15153	CYTL1		Cytokine-like protein 1	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9NRR1	Family	The function of this family of proteins, CYTL1, has not, as yet, been determined. However it is thought to be a secretory protein expressed in CD34+ haemopoietic cells [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 134 and 145 amino acids in length. There are two conserved sequence motifs: PPTCYSR and DDC.	27.00	27.00	75.40	27.90	21.10	20.80	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.56	0.71	-4.46	9	49	2012-06-28 14:21:46	2012-06-28 15:21:46	1	2	38	0	26	39	0	123.40	55	96.34	NEW	phsLhhLhsllu...hhhhup..ssPPTCYSRhLsLS+EIhsthpcLpsspsscsClchLPclalDlHNsClhoKLRDFlh......sspCtchs+lshLKc+lppLYsIhsphC+RDLVFhoDDCpALEsshsss.......phhs-.pp	....................h....hLLhLls...hs.hup..s...sPPTCYSRhLuLS+EIspsFppLQsoEPs-sCVchLP+LYLDIHNYCVLsKLRDFVA......SPpCh+hspVcsLK-KlRpLYTIMNSaCRRDLVFLoDDCsALEhPIsss.Ts.sD.............	0	1	3	9
+15006	PF15155	MRFAP1		MORF4 family-associated protein1	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9Y605	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 127 amino acids in length.	27.00	27.00	58.40	35.10	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.71	0.71	-3.80	2	52	2012-06-28 14:25:25	2012-06-28 15:25:25	1	4	22	0	17	44	0	117.90	79	68.99	NEW	MRPlDhsEhtEPcE....EPtp.....L.Ps.pthREslAuLpRE+uRAahRsRpKLhEhpshL.tIKopVEApEcuAhs.h.pPtsts-tRsA+hstcA-cKAtEhA+MuchlVELhpRIttsEss	.....................MRPLDIsElsEPEEVEVLEPEEDFEQFLLPVINEMREDIASLoREHGRAYLRNRSKLWEMDNMLIQIKTQVEASEESALNHlQsPustA-tRsuchCEKAEEKAKEIAKMAEMLVELVRRIE+SESS..................	0	2	2	3
+15007	PF15156	CLN6		Ceroid-lipofuscinosis neuronal protein 6	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9NWW5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 190 and 310 amino acids in length.	27.00	27.00	127.10	46.60	24.00	23.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-11.82	0.70	-5.30	4	65	2012-06-28 14:27:27	2012-06-28 15:27:27	1	3	39	0	31	62	0	249.00	76	86.16	NEW	RtGStcscs.sspsu.FHhDLWhhFTLQNWlLDFGRPIsMIlhPL-WFPLNKPSsGDYFHMAYNIITPFLLLKLhERSP+TLPRSslYlSIITFVMGASIHLVGDSlNHRLlhSGYQhHLSVRENPIIKsLpPtTLIDSFELLYYYDEaLGHsMWYIPFFLILFlYFTGCFTplKAEp+MPsSAWlLLuPSulYYWYLVTEGQIFIlFIFTFFAMlAhVhHQKR+GhlLDSNGLFLhYSFulTLhLVulWVAaLWNDpVLRKKYPGVIYlPEPWAFYTLHlpsp	...............ps--.sspsu.FHLDLWFYFTLQNWVLDFGRPIAMllhPLEWFPLNKPSVGDYFHMAYNVITPFLLLKLIERSP+TLP..RShhYlSIITFlMGASIHLVGDSVNHRLlFSGYQpHLSVRENPIIKNLKPETLIDSFELLYYYDEY....LGHsMWYIPF...FLILFhYFSGCFTssK..uE.u.pMPssALLLluPSuLY..YW...........YLVTEGQIFILFIFTFFAMLALVLHQKRKtLaLDSNGLFLF.SFuLTLLLVALWVAWLWNDPVLRKKYPGVIYVPEPWAFYTLHVSS.p...	0	2	5	13
+15008	PF15157	IQ-like		IQ-like	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q1A5X6	Family	This family of proteins includes Human IQ domain-containing protein J (IQCJ).	27.00	27.00	27.90	36.20	26.30	22.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.73	0.72	-10.32	0.72	-3.79	3	41	2012-06-28 14:29:59	2012-06-28 15:29:59	1	4	29	0	21	50	0	89.20	78	58.91	NEW	MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWRcYLpRQ-....sLGKRSPSPPSl...SSEKLSSSlSMNTFSDSSTP	.....EELKRLQNPLEQV......NDGKY.hENHQLA..MDsENNI.EKY.LNLQPLESKVKIIQRAWREYLQRQ-.....PLtKRSP.SPPSl...SS-KL.SSSVSMNTFSDSSTP	0	1	3	6
+15009	PF15158	DUF4579		Domain of unknown function (DUF4579)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q2WGJ8	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 192 and 239 amino acids in length. The human member of this family is C8orfK29.	25.00	25.00	25.90	25.60	18.00	17.50	hmmbuild  -o /dev/null HMM SEED	186	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.14	0.71	-4.77	4	30	2012-06-28 14:36:54	2012-06-28 15:36:54	1	1	24	0	22	27	0	156.90	47	77.13	NEW	Gh.psERpluppLppNpFaPFtp..pPssFhLEYhhsoLaKull.FIlhhlhlshthlscVp+Q-..........TWsF.sYGlulGLWLhISShPpRRLVLNHsRGsYHFSIQGRTVCQGPhHLVYVRLALsSDA.tthFapLlLsGaplEshlLspho-Rh-ph-hLGRhIAR+lNlNYFDshs.......sShRpVVRHWs	......................p.ccpltp+LppN.FaPFhp....pPssFlLEYhhcsLaKGhLhFllsllh.lsht......lppspcQ-..........TWsF.saGlsVGLWL..l..lS.S.LP+RRLVLNHs+GhYHFSIpGRTVCQGPhHLVYVRLALsSD..u.GphaapLVLsGa+lEshsLspho-+h-phEhLGRpIARKLNlNYFDhhs.......sShRHllRHWs..........	0	6	6	10
+15010	PF15159	PIG-Y		Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q3MUY2	Family	This family of proteins represents subunit Y of the GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex. It may regulate activity of the complex by binding the catalytic subunit, PIG-A [1].	25.00	25.00	25.10	25.20	24.60	24.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.48	0.72	-3.76	10	56	2012-06-28 14:46:25	2012-06-28 15:46:25	1	2	51	0	36	65	1	68.90	33	66.62	NEW	hhGsLhllhGllhFluhhauAVlscllPsussshlSulp.DhYYsLLlPlTLPVhlssVYapWLShKlFKHA	.....................huhhhllhshl.hsshhYus...s..ls...c.............hPps.sssh...hshh....aYsLLlPlTlPVhlhhshasWluhKhF+Hs....	0	15	22	29
+15011	PF15160	SASRP1		Spermatogenesis-associated serine-rich protein 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q496A3	Family	Spermatogenesis-associated serine-rich protein 1 is a serine-rich protein differentially expressed during spermatogenesis [1].	27.00	27.00	31.60	36.20	25.90	26.40	hmmbuild  -o /dev/null HMM SEED	244	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.72	0.70	-5.14	3	40	2012-06-28 14:52:34	2012-06-28 15:52:34	1	3	28	0	18	50	0	193.70	59	77.00	NEW	Ap+SDFLESKGCFANTTSS..GRSVSsSSSVETGLSVo-uPGLPRVhsYlDTAADLDpKoSSSHS........DHSSEsSLPEVQKDKYPEEFSLLKLQTKDGQRPEWTFYPRFSSNIHTYHVGKQCFFNGVFLGNRRSLSERTVDKCLGKKKYDIDPRNGIPKLTPGDNPYMaPEQSK-FaKAGSTLPPVNFSIVPYEKKFDTFIPLEPLPQIPNLPFWVKEKANsLKNEI+EVEELDNWQPAVPFLHuLLso	.....................................p..h.tSpts.Apthss..sppsS..SsstpG.plpts.u.s+s.s..s.sstLs.K.S.opS..................s+S.chSLPEl.KccaPcEFSLLp.QTpDGpRPEWTFYPRFSSNIHTYHVGKQCFFNGVFhGN++SluERTVDKshG+KK..YDIDPRNGIPK.LTPGDNPYMaPEQSKsFaKAGSTLPPVNFS.lsPYEKKaDTFIPLEPLPplPsLPFW.KEKANpLKNEIpEVEELDsWQsuhPhhp.hh..................	0	5	5	9
+15012	PF15161	Neuropep_like		Neuropeptide-like	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5BLP8	Family	This family contains putative neuropeptides [1].	27.00	27.00	29.90	58.60	25.90	19.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.05	0.72	-4.49	3	42	2012-06-28 14:58:50	2012-06-28 15:58:50	1	2	30	0	23	43	0	60.10	73	47.24	NEW	A-p-AGSAIPAESRPCVDCHAFEFMQRALQDLKKTAYNLDoRTEoLLLQAEKRALCDChPAs.L+	........t..uGoslPApSRPCVDCHAFE.FMQRALQDL+KTAaSLDuRTETLLLpAE+RA...LCsChPA.....t....................	0	1	3	10
+15013	PF15162	DUF4580		Domain of unknown function (DUF4580)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VVC0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 63 and 185 amino acids in length.	27.00	27.00	41.10	62.70	26.50	26.00	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.87	0.71	-4.88	6	41	2012-06-28 15:08:27	2012-06-28 16:08:27	1	1	33	0	25	38	0	157.00	62	91.64	NEW	sssp.ssslIIsuSLpsSElsphLps..psHKlRhScoltcsollFPLSGVAFLLlss.ph.h.......lsclppFlsh+pNuallLsuslas.pphthh..l..pRFLG.psLplLPVHssupslphMtTIAKhTsKPhhssIppRhpph+uhhlsp..usVWchLpplsLsp	........EphcWoTTlIISSSLcuaElATALEN..RSHKVRYSDSVEsGSIIFSLSGVAFLLMDscEChhSs...........EEhFLsKIEKFINIHpNSFLVLsAALHGPEEWcLMFRI.QQRFLG.sNLRILPVHNTsNAlsLMCTIAKoTSKPalDsICYRMIssKAYIIEQ..SPVW+TLQKIpLs.................................	0	4	6	9
+15014	PF15163	Meiosis_expr		Meiosis-expressed	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JSS6	Family	This family of proteins is essential for spermiogenesis [1].	27.00	27.00	50.90	50.80	20.40	17.00	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.78	0.72	-3.62	10	56	2012-06-28 15:09:45	2012-06-28 16:09:45	1	3	50	0	36	56	0	75.20	66	74.37	NEW	hoRAKcWScElEssYRFQpAGYRDElEYpplcpss.sERWPsp..GFVKKLQR.+DGsFhYaNKpREC-DK-lpKVKlYs	......hSRAK+WSEEIENLYRFQQAGYRDElEY+QVKQVuhVDRWPET..GYVKKLQR...RDNTFYYYNKpREC-DKEVHKVKlYt............	0	10	13	20
+15015	PF15164	WBS28		Williams-Beuren syndrome chromosomal region 28 protein homologue	Bateman A	pcc	Jackhmmer:Q6UE05	Family	WBS28 is an integral membrane family. These proteins have been identified as being linked to Williams-Beuren syndrome, OMIM:194050.  This family of proteins is found in eukaryotes, and are typically 266 amino acids in length.	27.00	27.00	27.10	62.60	19.60	26.80	hmmbuild  -o /dev/null HMM SEED	267	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.07	0.70	-5.31	5	30	2012-06-28 15:40:57	2012-06-28 16:40:57	1	1	22	0	16	30	0	239.20	61	99.54	NEW	MEAlPsVRSSLhGILLlVlKLSVLLVQNRlHLYNFLLLKIsLFNHWLSGLAQEApGSss.Qs.HPPusIAACPLGRlLRAGLALlEVPsWLlLRGPRLsWAGhLGCARALGLAPKaLuAWEQLGLSAATWTDLFLSCLHuLMLAALLLLLLTWRLCQKAHCCuLGRLLSKALLtN+VVhcLLALLKRLYWWVEopTALTSWHLAYLITWTTCLASHLLQAAFEHTAQLAQAQEsEPQKu.SGsSSEoPLPEPsuPEAGPVLPEPGTPGE	....................MEAhP.VRSSLhGILLpVh+LSVLLlQNRsHLYNFLLLKIsLFNHWVSGLAQEApGSts.Qs.h.P.sh.suCPLGpALRAGLuLlpVPhWLlLpuPRLsWAuhLsssRslGLAh.hLuAWE.LGLSs.AsWpDLhLSCLHuLMLVALLLlLlTWRLCQKAHp.huLGhLh.SpAL..NplVhchLA.LRRLYWWVEohsALTSWHLAYLlTWTTCLASHLLQAAFEHTAQLAQ..AQEsEspcs.SGs...tssLsts.ssEuGslLsE.tTPtE........	0	1	1	1
+15016	PF15165	REC114-like		Meiotic recombination protein REC114-like	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z4M0	Family	REC114-like members are necessary for meiotic DNA double-strand break formation. It functions in conjunction with Mei4. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 259 amino acids in length.	27.00	27.00	49.40	27.60	26.80	26.10	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.90	0.70	-11.66	0.70	-4.63	7	59	2012-06-28 15:59:42	2012-06-28 16:59:42	1	3	38	0	29	53	0	177.40	46	87.50	NEW	WPLpRYGRFh..sptcssssups.uttssPsWKVF-SNEESGpLlLTIVlSGHFFISQGQTLLEGFSLIsSpsWLK.IVRRhDCLLFsTshK....scSRhFRVQFuGs.ScEpALE+CCuCVQKL.upYVTVQssDshsppLp.u.Pu..psscSQsccp..phs.p.us..thppppsshshtsuhss..sphSh..........ppLAQolLssc.c.LPhsYcpSuWsAEELGPFLRLCLMDQNFPAFVE-VEKELKKL	........................................................................+lhtptcpt..h.hsll.uGahhl.pGpt.lLEG.FSLlsuppWLK..IsR+hDCLLFssphK....sc.SRhFRVQFuGp.S+EpALEcCsSCVQ+L.upYloVQhsDs..ppht.....Pu..tsstpp.pst...h..p.t..............tts..t..tphSh..........tpluQ.t..hLspt.t.LP.sYcp.....usassp-LtshLRLCLhDpsFPAFVEcVEcELKKl..............	0	5	9	14
+15018	PF15167	DUF4581		Domain of unknown function (DUF4581)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N3F0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically 131 amino acids in length.	27.00	27.00	39.80	38.80	20.70	16.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.71	0.71	-4.24	3	37	2012-06-28 16:04:52	2012-06-28 17:04:52	1	3	31	0	20	34	0	108.80	82	93.65	NEW	cpLADsAEKWCossPFDLIAsE-s.ERRhDFYA-PGlSFYVLCP-s..GssDpFHVWSESEDCLPFLQLAQDYISSCGKKTLHEILEKVFKSFRPLLGLPDVDDDTFEEYNADVEEEEPEADHQQMGVSQQ	..............ppLsDsA-KWCSssPF-LIhsE-s.ERRMDFYADPGVSFYVLCP-s..GCGDsFHVWSESEDCLPFLQLAQDYISSCGKKT.LHEVLEKVFKSFRPLLGLPDADDDAFEEYuADVEEEEPEADH.QMGVSQQ.........	0	1	3	9
+15019	PF15168	TRIQK		Triple QxxK/R motif-containing protein family	Eberhardt RY, Coggill P, Hetherington K	rdf	Jackhmmer:Q629K1	Family	TRIQK member-proteins share a characteristic triple repeat of the sequence QXXK/R, as well as a hydrophobic C-terminal region. Xenopus and mouse triqk genes are broadly expressed throughout embryogenesis, and mtriqk is also generally expressed in mouse adult tissues. TRIQK proteins are localized to the endoplasmic reticulum membrane.  This family is found in eukaryotes and members are typically between and 86 amino acids in length.	27.00	27.00	48.80	48.80	21.00	20.30	hmmbuild  -o /dev/null HMM SEED	80	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.66	0.72	-4.06	6	38	2012-06-28 17:39:22	2012-06-28 18:39:22	1	1	32	0	21	31	0	75.90	70	94.04	NEW	MGR........KDASos+hPVDQYRKQIGK.QDYKKTKPlLRAT+LKAEAKKoAIGIKElhLh...lsAILsLLhAaYAFFaLplSsshsl-	.........MGR........KDAuThKLPVDQYRKQIGK.QDYKKTKPILRATKLKAEAKKTAIGI.KEVuLV...LAAILsLLLAFYAFFYLpLos-lD.s................	0	4	6	9
+15020	PF15169	DUF4564		Domain of unknown function (DUF4564)	Bateman A	agb	Jackhmmer:Q9BQA9	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. This family includes the human protein C17orf62.	27.00	27.00	32.10	31.30	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.00	0.71	-4.56	8	54	2012-06-29 07:58:34	2012-06-29 08:58:34	1	2	47	0	41	65	0	171.20	52	93.47	NEW	M.YMplEc+TushLHLcRuPuIRSWSLhVGIuSlGLAAAYYSoDohLW....KlFYlsGClFVALQNlE-WEEAlFsKpKsclpLcohsLYchlLTh.+tGpEp..VVl-LcclRDlsVQEE+lRYhGcGYlll...LRassGhSaPLTQoushGsRSDVEAlAshls+FLphcpltup...phspopssDsDpspDpu	...................................M.YMpVEp+TuohLHL.KRuPGIRSWSLLVGIhSlGLAAAYYSuDSlhW....KLFYVsGCLFVAlQNLEDWEEAlFsKssGcVhLKTFSLY++lLTL.+sGH-p..VVl.Lp-lpDVsVEEE+VRYFGKGYhVV...LRhuT..GF.SaPLTQSAshGp..RSDVEAlAcLIssFLcLcplps.t....p.spopsu-sst....st.................................	0	10	14	24
+15021	PF15170	CaM-KIIN		Calcium/calmodulin-dependent protein kinase II inhibitor	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z7J9	Family	CaM-KIIN is the inhibitor of Calcium/calmodulin-dependent protein kinase II (CaMKII). CaMKII plays a central part in long-term potentiation, which underlies some forms of learning and memory. CaM-KIIN is a natural, specific inhibitor of CaMKII [1]. This family is found in eukaryotes.	27.00	27.00	30.90	30.50	22.50	21.10	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.52	0.72	-3.99	5	59	2012-06-29 10:35:08	2012-06-29 11:35:08	1	1	33	5	31	45	0	72.70	70	98.10	NEW	MSElLPYSE-KMusYGsDu-VGQlSFSCRLQDTsuFFAGuQuKRPPKLGQIGRAKRVVIEDDRIDDVLKGMoDKuPPGV	...........MSElLPYu--KhutaGs-s-suphSFSCRLQDTNsFFuusQuKRPPKLGQIGRuKRVVIEDDRID.D.VLKsMs-KsPsGV.......................	0	2	6	14
+15022	PF15171	Spexin		Neuropeptide secretory protein family, NPQ, spexin	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q9BT56	Family	Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors [1]. Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance [2].	27.00	27.00	40.40	39.90	20.80	18.40	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-9.99	0.72	-3.99	3	34	2012-06-29 10:43:10	2012-06-29 11:43:10	1	3	27	0	20	24	0	79.00	66	73.58	NEW	APQRLFERRNWTPQAMLYLKGAQGRRFLSDQSRRKDLuDRPPLERRSPNop.LTLPEAAALLLASLpKuQEsE-ENhD+ocaLEDsLhNW	.APQthhERRNWTPQAMLYLKGAQGRRFISDQSRRKDLuDRs....PERRSPNsphLolsEAAAlLLASLQKspEstEcNhDp.sphL.DpLhsh....................	0	1	2	5
+15023	PF15172	Prolactin_RP		Prolactin-releasing peptide	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:P81277	Family	\N	27.00	27.00	32.60	32.20	23.90	18.30	hmmbuild  -o /dev/null HMM SEED	47	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.02	0.72	-8.46	0.72	-4.74	8	46	2012-06-29 10:46:53	2012-06-29 11:46:53	1	1	34	0	17	37	0	46.20	57	48.59	NEW	SRuap......Hsh-hRoP-IDPhWYsGRGlRPlGRFG+Rputhtcuupsph+	.........Rsap......HShEhRoPDIsPuWYsGRGIRPVGRFGRR+ushtcsspst..........	0	1	3	6
+15024	PF15173	FAM180		FAM180 family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6P0A1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 182 amino acids in length. There are two conserved sequence motifs: ELAS and DFE. The function of this family is unknown.	27.00	27.00	34.90	34.60	22.40	18.80	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.68	0.71	-4.39	7	69	2012-06-29 10:48:52	2012-06-29 11:48:52	1	1	38	0	40	57	0	133.30	48	77.10	NEW	LaPuAhRsKRu.uuhlNPs.....hQpolE-VpLLaElLLAGlphsst.tthplpDtELASLR+spcLcsICpcllP+pLs-I+RLoupLusphG..sL+hEDFERTlLThVYTA.plspu.pspQR-hWupohlpLapAlKtDL	..........LaPuApRsKRuuu.PlNPs........LQpShE-VELLaEhLLAtL-lsss.hplpIcDEELASLR+Apch+hlCpclIPKsls-I+RLsupLush.u..sL+p-DFERTlLThsYsAYRhshu.pucQ+-hWApuhspLaQAl+aDL..................................	0	2	3	11
+15025	PF15174	PRNT		Prion-related protein testis-specific	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86SH4	Family	PRNT is a family of prion-related proteins expressed in the testis [1,2].  This family of proteins is found in eukaryotes. Proteins in this family are typically between 52 and 94 amino acids in length.	27.00	27.00	37.50	87.20	17.80	16.80	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.09	0.72	-8.66	0.72	-4.31	3	15	2012-06-29 10:52:38	2012-06-29 11:52:38	1	1	15	0	1	13	0	49.00	70	73.43	NEW	NTsLhHSAWPLShLHQTVSTLKAVAVTHSLWHLQIPVDCQACNRKSKKIYC	NhPILLSHYPLP...QQTETWKAAsAllSLWaLQSPGDGQACDRESVKIYC	0	1	1	1
+15026	PF15175	SPATA24		Spermatogenesis-associated protein 24	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86W54	Family	This family of proteins bind to DNA and to TBP (TATA box binding protein), TATA-binding protein (TBP)-related protein 2 (TRF2) and several polycomb factors. It is likely to function as a transcription regulator [1-2].	27.00	27.00	52.40	29.70	22.10	26.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.15	0.71	-4.52	6	45	2012-06-29 10:53:44	2012-06-29 11:53:44	1	1	33	0	24	40	0	148.00	65	69.24	NEW	uKEEFpAlcKcL.-EKstHAKTKsLLAKEpEKLQFALGEV-VLSKQLE+EKhAFEKAhusVKsKAhQESuc+DQLloKCsEhp...pcll....+QEDlLNuKE.cI+-LpphlupQKpsh..............H+sphS-hc..........IQppQ-tYh..sp.h.scs+hpputphsGp	.....................SKEEFQAVEKKLV.EEKAAHAKTKlLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKS+VLQESSKKDQLITKCNEIE...SHII....KQEDILNGKENEIKELQQVISQQKQIF....................psphSshR..........IpK.Qtphh..ApslstKpKhssuh.....s..............................	0	7	8	10
+15027	PF15176	LRR19-TM		Leucine-rich repeat family 19 TM domain	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IVY1	Domain	LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity [1]. This family of proteins is found in eukaryotes.	27.00	27.00	45.60	44.30	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.76	0.72	-10.58	0.72	-4.33	9	67	2012-06-29 10:54:56	2012-06-29 11:54:56	1	8	31	0	41	50	0	103.90	48	43.54	NEW	souSssuPusuoG...uRuWPlLVGVVluAlllSLLIALAAKCpLC++ahsSYpH+PLsEs.....................GpuspPsVs.....csE...............DDDGFIEDNYIQPutst.Es	..........s.outsshstsups....u+uWshLVGVVlsslshSLLIhlAhKC.lhhpahhSYpH+.LpEp..........................GhsspPpss.....psc...............DDDGFIEDpYIpstphp........	0	2	6	12
+15028	PF15177	IL28A		Interleukin-28A	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IZJ0	Family	The protein family, Interleukin-28A, plays an important role in modulating the immune system. This protein family is induced by viral infection and interacts with a class II receptor [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 195 amino acids in length.	27.00	27.00	30.10	30.10	25.00	19.40	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.11	0.71	-10.85	0.71	-4.73	10	96	2012-06-29 10:56:35	2012-06-29 11:56:35	1	3	32	6	51	94	0	145.40	55	79.55	NEW	ssuKGCHluQFKSLSPQELpAFKKAKDAlEESL.LKsWsCSSRLFPRshDL+QLQVhERPVALEAELALTLKVLEshADo..uLuslLDQPLHTL+HIHSpLQA..ClpsQPTAGP.RP+GRL+HWLHRLQEAsKKEStGCLEASVTFNLFRLLTRDLKCVASGD	........pt+uCclupFKSLSPp.ELpAFK+A+DAhE.-SLh.KshpCpS+lFPRshDL+pLQ......V.hERPlALEAELsLTLKVL.pshscs..uLsclL-QP....L+TL+HIpSpLpA..ClpsQPTAuP....+P.pGR.L++WLHRL.....pEA..cKESsGCL.EASVhFNLFRLLTRDL+CVAsGD.......	0	3	3	14
+15029	PF15178	TOM_sub5		Mitochondrial import receptor subunit TOM5 homolog	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N4H5	Family	This is a family of transmembrane proteins thought to form part of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex) [1]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 50 amino acids in length.	27.00	27.00	30.20	30.10	25.50	25.50	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.94	0.72	-8.55	0.72	-4.27	4	39	2012-06-29 10:58:52	2012-06-29 11:58:52	1	1	25	0	14	50	0	46.20	79	78.66	NEW	MF+lEGLuPKhDPEEMK+KMRpDVISSVRNFLIYVALLRlTPYILKKLDSI	..........MFRIEGLuPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPallp.............	0	3	4	6
+15030	PF15179	Myc_target_1		Myc target protein 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N699	Family	This family of proteins is regulated by the c-Myc oncoprotein. It regulates the expression of several other c-Myc target genes [1].	27.00	27.00	27.70	27.20	25.10	24.80	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.42	0.71	-11.33	0.71	-4.72	7	50	2012-06-29 10:59:41	2012-06-29 11:59:41	1	1	38	0	29	42	0	176.40	62	89.94	NEW	MApNsTshh.phhcsF.apsllLAFslSMllGLllGulIahllThhS.RRRASApIoptsspppppp...pS.s.hts+hGaYR.souh-R+Ss.SL..AuLohpRQsSlE.s...sshsRKsSFcuSTF+Phhpss.hs..s-psuQh...........sshssssssssshs.sss..pRssFahussuLRshhsoQTPPPAYDSlI+AF.E..o	..................MApNsTslh.sWscsF.WEDLIhSFTVSMAIG.LVlGGhIWALhsCLS.RRR.A.SA..sISQWSsSRRoR.......SSasHuLNRTGFYR.HSGCERRSNLSL...ASLTFQRQASL.EQA...NSFPRKSSFRASTFHPFLQCPPLP..VET-SQL...........hTLPuSs...sossl..sosHSLuRPDaaWSsNSLRhuhST.sPPPAYESIIKAFPD...S.....................	0	1	5	13
+15031	PF15180	NPBW		Neuropeptides B and W	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N729	Family	The function of this family, NPBW, which includes Neuropeptides B and W, is thought to be involved in activating G-protein coupled receptors, GPR7 and GPR8. It is thought to play a regulatory role in the organisation of neuroendocrine signals accessing the anterior pituitary gland. It is predicted that this effect will stimulate the increase in water-drinking and food-intake. This suggests it plays a role in the hypothalamic response to stress. This family of proteins is found in eukaryotes [1,2].	27.00	27.00	31.90	31.70	20.40	20.00	hmmbuild  -o /dev/null HMM SEED	120	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.68	0.71	-4.47	8	57	2012-06-29 11:40:11	2012-06-29 12:40:11	1	3	30	0	29	48	0	111.70	41	85.80	NEW	sphshlslAlsLLlus.PutAWYKpsAGPuYYSVGRASGLLSGlRRSPYsRRS-scuuAts.ut.............suspsp.pssLRShslCVpDlsPNLpSCEhLsDGsGsa............QCKA-VFLSLcShDChsA	........t...shhslhLhLLlhs.PuhAWYKpsAuPpYYoVGRAuGLLSGlRRSPYh+Rupspsssts.u...............tsshp.pssl+ohs.........lhlpshs.pL.pschh.sstGhh............ptps-shLoLcuhDt.t........................................	0	2	4	13
+15032	PF15181	SMRP1		Spermatid-specific manchette-related protein 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NCR6	Family	This family of proteins, SMRP1, is thought to have a role in spermatogenesis and may be involved in differentiation or function of ciliated cells [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 260 amino acids in length.	27.00	27.00	85.50	85.50	25.50	25.20	hmmbuild  -o /dev/null HMM SEED	261	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.92	0.70	-4.99	5	38	2012-06-29 11:41:30	2012-06-29 12:41:30	1	2	28	0	21	48	0	226.30	62	93.33	NEW	MFLFSRKTKTPISTYSDSYRAPTSIKE.VYKDPPLWAWEANKFVTPGLTpTMcRHVDPEAL.QKMsKCAsQDYTYKuSISGHPYLPEKYWLSP-EtDKCsPsYLss.......D+YNTWRTuPYSsh.WNKYTTYLPRLPKEsGMEThVRGMPLEYPPKPERLNAYEREVVVNMLNSLSRNpsLPQIsPRCGCVDPLPGRLPFQGYESsCSGRHYCLR..GMDYhsoGsPsT-RRLRPLCscpPThpolLpsssRsulsC.........YsSPslIlPhSEP	..MFLFSRKTKTPISTYoDSYRAPTSIKE.VYKDPPLhAWEANKFlT....PGLTpTM.cRH.VDPEAL.QKMsKCAsQDYoY+uSIsGHPYLPEKYWLSp-E.....t......DK.......CsPsYLsu.......DRYNTWRhuPYNsosWNKYTThLPRLPKEAGM.ETsVRGMPL-hPPKPERLNAY.......EREVhVNMLNSLSRNQ.LPpIsPcCGCscsLPGRLPFpGY-SsCSGRHYCLR..GMDYhssGsPss-R.+Lpshs.pp.T.pss.......tRsshpC.........Ys.Pslhhsh.p...............................................	0	2	2	6
+15033	PF15182	OTOS		Otospiralin	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NHW6	Family	This family of proteins, Otospiralin, has a role in maintaining the neurosensory epithelium of the inner ear [1,2]. This family of proteins is found in eukaryotes. Proteins in this family are approximately 90 amino acids in length.	27.00	27.00	60.30	60.10	22.10	20.80	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.98	0.72	-9.42	0.72	-4.31	4	41	2012-06-29 11:45:03	2012-06-29 12:45:03	1	1	35	0	27	29	0	66.30	70	77.66	NEW	A+Pl.tEtsPYtEsPAhPYWPaSTSDFWNYVpaFpolGAYsQlpDhARTFFAHaPLGsTLGacVs.p-E	......A+Pl.EEuDPYsEsPAMPYWPFSTSDFWNYVpYFQoLGAYsQIpDMARTFFAHFPLGoTLGaHVPYpE-....	0	1	3	11
+15035	PF15183	MRAP		Melanocortin-2 receptor accessory protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8TCY5	Family	This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.	27.00	27.00	54.50	50.30	25.90	25.90	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.20	0.72	-4.38	6	76	2012-06-29 12:32:18	2012-06-29 13:32:18	1	2	40	0	41	79	0	84.20	54	53.03	NEW	MANpTNuSs.aaSYEYYLDYlDLlPVDE+KLKAsKYSIVIAFWVSLAsFVhhLFLILLYMSWSGSP.Qs..Rsusppa.hCsWs+uhsLPLCl	...........pusss..Ss.h..apYEYY.-h..h.PVs.ctLKAHKYSIVIuFWVuLAsFVlFhFhlLhhhohoGuP.Q....csut++aphssaspshsh.Lp.................	0	2	5	14
+15036	PF15184	TOMM6		Mitochondrial import receptor subunit TOM6 homolog	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96B49	Family	TOMM6 forms part of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex) [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 43 and 74 amino acids in length.	27.00	27.00	36.20	49.70	24.20	18.50	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.22	0.72	-4.64	3	36	2012-06-29 12:33:59	2012-06-29 13:33:59	1	1	28	0	16	40	0	70.80	80	98.87	NEW	MSuSsVKs.uAGSuG........VuDWlRusCRFATDRNDFRRNLLVNLGLFAAGVWVARNLSDFDLMSPQPlT	..............MASSGVsVoAAGSANEsPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV........	0	1	1	2
+15037	PF15185	BMF		Bcl-2-modifying factor, apoptosis	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96LC9	Family	BMF is thought to play a role in inducing apoptosis.  It is thought to bind to Bcl-2 proteins [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 75 and 190 amino acids in length. There are two conserved sequence motifs: GNA and DQF.	27.00	27.00	27.30	27.00	17.80	17.20	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.50	0.70	-5.05	4	51	2012-06-29 12:35:41	2012-06-29 13:35:41	1	2	32	1	21	64	0	159.20	56	91.31	NEW	-hPpCsEpshpphct..........................ccDsapu-sup.............sspsushhAuulhspspphDs..tchph.PlophhGsshRshptp-+ATQoLu.usuup.............ulhhsCGlptpP+tLFaGNAGaRlHh.PAsFthu.shhEpspptQ....................p.thpsEVQIuRKLppIuDQFpp.HlQ....pHppN.sthhh.lhhFhc.Lh.p.t...pssG.p	.............................................................................CVE........L.........................EDDVFQPEDGE............PusQPGuhLSADLFAQS..LDCPLSRLQLFPLTHCCGPGLRPsuQEDKATQTLSPASPSQ.............GVMLPCGVTEEPQRLFYGNA.GYRL.l.PAuFsss.shtEpP.EuQ......................pHRsEVQIARKLQCIADQFHRLHhQ.......pHQQNpspsWWQlhLFLpNLALNtctNRpssG...........................	0	1	3	7
+15038	PF15186	TEX13		Testis-expressed sequence 13 protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BXU2	Family	The function of this family of proteins has not, as yet, been determined. However, members are thought to be encoded for by spermatogonially-expressed, germ-cell-specific genes [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 177 and 384 amino acids in length. There are two conserved sequence motifs: FIN and LAL.	27.00	27.00	82.70	79.20	21.80	20.20	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.24	0.71	-10.74	0.71	-4.64	12	77	2012-06-29 12:37:16	2012-06-29 13:37:16	1	2	22	0	44	57	0	147.00	52	44.30	NEW	cs-DsoSGF+HucVlhFINEchu+pu+GPEFYL-NlSLSWEEVEDKL+sIL-DopVPpplKcACsWuoLALGVRFAtRQsQLQu+RVpWLpDhupLH+SAAhuLAS-LpcLpcQpEhEppEAAhQLp.spspLtEsp+ERDlhRh+lhpsEL	.....s-DPuSGFRHucVltFINEchspps+GPEFYlpNhShSWcEVEDKLRuILpDopVPppsKcACsWuuLALGVRhApRQtpLQs+RVphLp-hsc.H+oAu.ALAS-LpcLppppEh-ppEAAhQLphspssLtcspcERDhLph+Lhph..................	0	2	2	4
+15039	PF15187	Augurin		Oesophageal cancer-related gene 4	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H1Z8	Family	Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterised by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation [1]. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF [2]. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.	27.00	27.00	81.90	81.80	24.00	23.40	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.58	0.71	-4.22	9	52	2012-06-29 12:39:44	2012-06-29 13:39:44	1	1	39	0	31	47	0	112.90	68	82.25	NEW	spLc+lLpKR-sst...sPu+ssVAVstuKAKEFLusL+RsKRslWDRSRPDVQQWIQQFMYMGFDEs+LEsDLSYWMDpuRuuDQG....RQHHYDENAsIGPRsP.....poaRHGAsVNYD.Y	....NKL+hhLQKREAs....sPoKspVAV..sEsKAKEFLuSL+RpKRQLWDRoRP-VQQWYQQFLYMGFDEAKFEDDloYWhN+sRsGc-YY.sYaQ+HYDEDuAIGPRsP.....toFRHGAuVNY.DDY	0	1	6	13
+15040	PF15188	CCDC-167		Coiled-coil domain-containing protein 167	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9P0B6	Family	The function of this family of coiled-coil domains, has not, as yet, been determined. Members of this family remain uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between and 103 amino acids in length.	27.00	27.00	28.20	27.60	26.50	25.50	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-9.76	0.72	-4.04	11	60	2012-06-29 12:41:00	2012-06-29 13:41:00	1	2	48	0	40	60	0	83.00	45	80.04	NEW	hSVs+EIDphEEclspC+ppl-plEp+L+cpcLocEpRpslE.......cEhstlpppLps.EccLptL++......ENpKshhlusAlhhlphLlYs	............uVs.EIDGLEEKLupCR+cLEsVss+L+ptELSsEsRcuLE.....................cE+ssLhs+hpshE+ELphLRp......ENRKshhLusulhllhsLlY......	0	8	11	21
+15041	PF15189	DUF4582		Domain of unknown function (DUF4582)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A2RUB1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 126 and 788 amino acids in length. In humans, it is encoded for on the chromosomal position, C17orf104.	27.00	27.00	34.80	28.40	19.60	24.50	hmmbuild  -o /dev/null HMM SEED	172	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-10.69	0.71	-5.03	10	105	2012-06-29 12:45:26	2012-06-29 13:45:26	1	4	56	0	70	98	0	140.20	36	32.71	NEW	pRousus-LHhpLEEChEQaRpLEKERKKTEA-LARpshGK+VS.SoNNhPlPRLsssPSRVDRLIVD.hREHAR..VlTLLuKMEpLRusslssslapALcpaLEAI+hlQspRpsEhhNhlpp.R...tth..h+ap-D+DlhsLAuAlpplspAsR+ARTAhWCuL.hTLshssssp	.........p.G.hpplph+h.psh.Q.pth-.cE.c.pKpp.uLupNh.tctlp.SpsphslsRh.sus....sSRV.s.Rhhlsphpp.up..lhs.Lt+....cp...LtSs.sh.hphopshs+pl.slh.s.shhpp-hh...................................................................s..........................	0	16	21	38
+15042	PF15190	DUF4583		Domain of unknown function (DUF4583)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q8N6I4	Family	This family of proteins, also known as UPF0694, is found in eukaryotes. Proteins in this family are around 135 amino acids in length. In humans, it is found on the chromosomal position, C14orf109.	27.00	27.00	33.10	32.20	21.90	20.40	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.85	0.71	-10.86	0.71	-4.50	3	53	2012-06-29 12:59:36	2012-06-29 13:59:36	1	3	42	0	32	56	0	123.10	77	85.96	NEW	MNFRQRMGWIGVGLYLLASsAAsYYVFEIS-TYNRLALEHIQp...........suppsPSuTTWppTLKTRLLuLPFWhWslIFLlPYLQVFLFLYSCTRADPKTVGYCIlPICLAVlCNRHQuFsKAS...NQISRLQLI	.MNFRQRMGWIGVGLYLLASAAAFYYVFEINETYNRLALEHIQQ...........HPEEPhEGTTWTHSLKARLLSLPFWLWTlIFLlPYLQMFLFLYSCTRADPK.TVGYCIIPICLAVICNRHQAFVKAS...NQISRLQLI............................	0	7	9	16
+15043	PF15191	Synaptonemal_3		Synaptonemal complex central element protein 3	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A1L190	Family	\N	27.00	27.00	67.30	67.20	23.10	19.80	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.30	0.72	-4.25	2	24	2012-06-29 13:00:14	2012-06-29 14:00:14	1	1	22	0	14	28	0	84.90	78	98.03	NEW	Mssu.s-.p.h-sh.p...pLNpcLEKhhEpMEclSVphohMsYDMVVhRTsPsLAESh+pLEstF.pCK.........pEhcpp.t-..p.o.p	...MADuDPsERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFLNCK.........EEMEKNWQELLpETKp........	0	1	3	3
+15044	PF15192	TMEM213		TMEM213 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A2RRL7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 154 amino acids in length. The function of this family is unknown.	27.00	27.00	99.80	99.70	21.40	20.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-10.07	0.72	-3.97	3	30	2012-06-29 13:01:11	2012-06-29 14:01:11	1	1	27	0	20	29	0	78.70	73	69.80	NEW	uAusSs.SssouuTsH+PcsGTLSs..Cs-VDFCPQAARCC+TGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPKDLQA	.............t..tAou.SssSolTsHHPDs.GTLEp..C.NVDFCPQAA+CC+sGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPKDLpA.	0	1	1	4
+15045	PF15193	FAM24		FAM24 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NFZ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 101 amino acids in length. There are two conserved sequence motifs: FDLRT and CLY. The function of this family is unknown.	27.00	27.00	37.60	37.60	17.10	15.90	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.64	0.72	-3.79	6	38	2012-06-29 13:01:55	2012-06-29 14:01:55	1	2	16	0	19	39	0	68.70	51	71.62	NEW	LY.KIuKALKsA+.....-sEssh....DPsKssp-phIp.............AKsIssEoCtsLQCC-sCuhatsssSLPPChCshNEGL	...LYhKlu+ALKAAK.....-s-ssA....NPsKshh.sKs..p.............AcohssESCPuLQCC-sC+MYAsaDuLPPChCDlNEGL.	0	2	2	2
+15046	PF15194	TMEM191C		TMEM191C family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NGB0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 302 amino acids in length. There are two conserved sequence motifs: QDC and RLF. The function of this family is unknown.	27.00	27.00	36.00	36.00	23.50	22.20	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.45	0.71	-4.23	3	23	2012-06-29 13:02:45	2012-06-29 14:02:45	1	2	17	0	11	31	0	105.90	59	74.86	NEW	MEAAAALDAoRSGpEPCDSQLRRVQDCoGSLMEEVARADCEKRLFGGAGAGuIRLWALGALQTLLLLPLGFLuLPLLYLVLlcPsAlusGLtSLoS-AsLRRLRYTLSPLLELRARGLLPA	.....................................................MEAAAtLDAhpuGpEPhDup.RtVQ.sstSLMEEVARADp.EhRLFGG.ssA.............hul.RhhsLuALQsLLhLPLhFLsLsLLahsLhcPsAlpthL.tpLsS-sshRRLRYTLSPLLELRApGLLPs.............	0	1	1	1
+15047	PF15195	TMEM210		TMEM210 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NLX4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 149 amino acids in length. The function of this family is unknown.	27.00	27.00	27.00	60.70	26.90	18.10	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.67	0.71	-10.62	0.71	-3.96	3	17	2012-06-29 13:03:35	2012-06-29 14:03:35	1	1	15	0	8	14	0	105.80	72	79.88	NEW	TYCECSLGLSREALIALLVVLAGVSASCFCALVIVAIGVhRAKGETCPRHs-NRLVGsYGVQEDRMDLHTVaVESHLMDPDLEVSMMPPLE-QGLhsMThPl-P.sP....PPPPPLsPp	TYCECSLGLSREALIALLVVLAGlSASCFCALVIVAlGVlRAKGETC.Ptth-sRLVtpFGVQEDpMDLHsVaVESpLMDsDLEVShMPPLE-puLhsIsM-sssEEP....PPPPP..P............	0	1	1	1
+15048	PF15196	Harakiri		Activator of apoptosis harakiri	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O00198	Family	\N	27.00	27.00	126.40	126.10	19.90	19.10	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.41	0.72	-3.74	2	15	2012-06-29 13:04:25	2012-06-29 14:04:25	1	1	14	2	9	12	0	91.20	88	100.00	NEW	MCPCPhHRGRGPPAVCuCusuR.GLR.uAAQlTAhRLpALGDELHpRsM.RRRARsRc.PhPuhLPsh...WPWLCAAAQVAALAAWLLGRRsh	MCPCPLHRGRGPPAVCACSAGRLGLRSS.AAQLTAARLKALGDELHQRTMWRRRARSRRAPAPGA.......LPTY...WPWLCAAAQVAALAAWLLGRRNL	0	1	1	1
+15049	PF15197	Leukemia_assc_2		Leukemia-associated protein 2	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O43262	Family	\N	27.00	27.00	53.80	89.80	19.50	18.50	hmmbuild  -o /dev/null HMM SEED	53	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.99	0.72	-8.77	0.72	-4.30	6	9	2012-06-29 13:05:10	2012-06-29 14:05:10	1	1	7	0	1	6	0	53.30	76	83.92	NEW	MKMSFERCTARNKMFVNSAFTK.VDNYCTFL.KKhhhKshF.lphhpKtKK.DLNF	MKMSFERCTARNKMFVNSAFTK.VDNYCTFL.cKhhFKshF.lphhpKtKK.DLNF..	0	1	1	1
+15050	PF15198	Dexa_ind		Dexamethasone-induced	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95424	Family	\N	27.00	27.00	138.80	138.60	22.60	16.60	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.43	0.72	-4.07	2	27	2012-06-29 13:05:54	2012-06-29 14:05:54	1	1	27	0	19	18	0	90.90	90	99.92	NEW	Mssu.VhhpLDultsLls......LP.MaYlGLFFVNVLILYYAFLMEYIVLNVGlVFLPEDMDQALVDLGVLSDPuSh.YDsDoELDVF-GYLE	..M.GARVAAHLDuLGPLVsaVPPPLLPSMFYVGLFFVNVLILYYAFLMEYIVLNVGLVFLPEDMDQALVDLGVLSDPGSGLYDADSELDVFDGYLE	0	1	3	7
+15051	PF15199	DAOA		D-amino acid oxidase activator	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P59103	Family	\N	27.00	27.00	53.50	52.80	18.70	16.90	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.85	0.72	-3.35	2	15	2012-06-29 13:06:51	2012-06-29 14:06:51	1	1	6	0	2	10	0	67.10	71	58.39	NEW	MAQRHLQRSLCPWVSYLPQPYAE......H.uKVhhstNhc...................Cpapp.pp..ssHh..ssTc.t	........MAQRHLQRSLCPWVSYLPQPYAELEEVSSHVGKVFMARNYE.....ASKDRRQPLERMWTCNYNQQKDQSCNHKEITSTKAE.	0	2	2	2
+15052	PF15200	KRTDAP		Keratinocyte differentiation-associated	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P60985	Family	\N	27.00	27.00	76.00	68.30	25.50	18.40	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.29	0.72	-9.76	0.72	-4.21	3	29	2012-06-29 13:07:40	2012-06-29 14:07:40	1	1	23	0	16	20	0	76.80	71	78.34	NEW	AALGoPp...EDTThuNYPoGTEGLNuEFLNFcKLQSAFKSD-FLNWHVLTDMFK+ALPFINWDFFPKVKGLRSAsPDSQ	AuLGusE....EETTIsNYAutPEAFNspFLNlDKLRSAFKs-EFLNWHALFESIK+KLPFLNWDAFPKLKGLRSATPDAQ.	0	1	1	2
+15053	PF15201	Rod_cone_degen		Progressive rod-cone degeneration	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q00LT1	Family	This family of proteins is involved in vision [1].	27.00	27.00	29.70	29.70	18.40	17.40	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.35	0.72	-8.61	0.72	-4.12	5	14	2012-06-29 13:13:08	2012-06-29 14:13:08	1	1	12	0	8	16	0	49.10	76	96.08	NEW	MCTTLFLLSTLAMLWRRRFANRVQPEPScVDGAVVGSuSETDLQSSGRE+..uPVK	MCTTLFLLSTLAMLWRRRFANRVQPEPSsVDG..AVhGSS.-sDhQSSGRcc..pPlK...	0	1	1	1
+15054	PF15202	Adipogenin		Adipogenin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q0VDE8	Family	This family of proteins is involved in the stimulation of adipocyte differentiation and development [1].	27.00	27.00	36.10	81.80	26.30	22.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.48	0.72	-9.98	0.72	-4.11	2	20	2012-06-29 13:14:00	2012-06-29 14:14:00	1	1	14	0	8	23	0	73.80	79	66.89	NEW	MKYPLhPLVNDLThSFLVFWhCLPVuLLL.LhIlWL+FLLSQDScEsDSslChsWEPWSKGPuE.shcGThpGQEcc+..W	.MKYPLhPLVNDLTFSFLVFWhCLPVGLLLFLLIIWLRFLLSQDSEENDSsVChDWEPWSKGPAEFCWcuTLHGQEcERPC.h....	0	2	2	2
+15055	PF15203	TMEM95		TMEM95 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q3KNT9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length. There is a conserved LGG sequence motif. The function of this family is unknown.	27.00	27.00	86.10	33.20	21.10	19.40	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.51	0.71	-10.91	0.71	-4.81	3	20	2012-06-29 13:14:47	2012-06-29 14:14:47	1	2	16	0	8	32	0	134.10	68	76.95	NEW	CVFCRLPAHDLSGRLA+LCSQsEA+pKECGASssFsAFALDEVSMN+VTEKTHRVLRVMEIKcSlSSLPLYWpWLRKTKLPQYTREALCAPAC........RGSTTLYNCSTCcGTEVSCWP+KRCFP.......GSQDLW-A+ILLLsIFGtsLLLGuLSLLVEp+	..CVFCRLPAHDLSGRLARLCSQMEAp.K.ECGASPDFSAFALDEVSMNKVTEKTHRVLRVM.EIKculSSLPsYWpWL+KTKLPcYTREALC..sPAC........RGSThLYNCSTCcGhEVSCWP+KRCFP.......GSpD.h.h+lh.hss.Gss...Gsl.............................	0	1	1	1
+15056	PF15204	KKLCAg1		Kita-kyushu lung cancer antigen 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5H943	Family	This is a family of cancer antigens [1].	27.00	27.00	37.10	87.60	18.90	17.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.14	0.72	-3.95	2	17	2012-06-29 13:15:39	2012-06-29 14:15:39	1	1	13	0	5	20	0	87.10	72	78.31	NEW	QpssGEMSSNSTuLALVRP.SSoG.hpSNTDpN....LuVhsLShDIL.N.P+oIshQKRhLVNLphhp.KLsELEHhLl.KGhpGA.sphKS	....QRNTGEMSSNSTALALVRP.SSTGLINSNTDNN....LSV.cLSRDIL.NNFPHSIAMQKRILVNLphVE.KLsELEHhLVSKGhRGASsHRKS...	0	1	1	1
+15057	PF15205	PLAC9		Placenta-specific protein 9	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JTB6	Family	This family of proteins was identified as being enriched in placenta [1].	27.00	27.00	28.30	27.70	22.00	20.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.94	0.72	-9.45	0.72	-3.70	4	31	2012-06-29 13:16:29	2012-06-29 14:16:29	1	1	23	0	14	30	0	68.10	66	72.19	NEW	AEP.sPutGDsutSsuCDRaMAVpcRLDVhEETVEKTVEHLEAEVKGLLG.LEELAWNLPPGPFSPhPDLLGDs	...........AEPhsPspGDsApSTsCDRHMAVQpRLDVhEEhVEKTV-HLtsEVKGLLGLLEELAWNLPPGPFSPsPDLLG-s.........	0	1	1	3
+15058	PF15206	FAM209		FAM209 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5JX69	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between and 170 amino acids in length. The function of this family is unknown.	27.00	27.00	123.80	123.60	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.79	0.71	-4.39	5	40	2012-06-29 13:17:50	2012-06-29 14:17:50	1	1	24	0	22	48	0	149.80	61	88.16	NEW	FMFSSLREKsKEPQGKVPCGGHFRIRQNLPEHTQGWLGSKWLWLhFVVVLYVILKFRGDSEKNKEQoPPGLRGCoaRSPlRKpQNASPNKDYAFNTLTQLEMDLVKFVSKVRNLKVuMAT..uSNLRLQsLEuPADPaNNVTIYEIWGEEDS	.FMFSSLREKspE....PQGKVPC....G.GHFRIRQNLPEHAQGWLGSKWLWLlFVVVLaVILKF....ptDu.EK..NKEQo.PsGLRGssFRSPLKKsQNASPsKDhsFNTLspLEh-LVKFVSKVRNLKsAMAT..uSNL+LppsEhPADPap.lTIYEIWGEEsS...	0	2	2	3
+15059	PF15207	TMEM240		TMEM240 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q5SV17	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 54 and 175 amino acids in length. The function of this family is unknown.	27.00	27.00	94.00	93.90	26.60	21.00	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.31	0.71	-11.32	0.71	-4.70	2	25	2012-06-29 13:18:38	2012-06-29 14:18:38	1	1	21	0	18	34	0	141.90	78	98.56	NEW	Mph.ssThhhMlhGAslVhAIsCl.DMNALLDRFHNaILP+hRG.-RVCHCsCGRHHVcYVIPY-GstSLssuSts..susSVoKQEhDLhLGLLhGFCISWlLLWLDGAhHCAlRhWRuSRaYss...SWpWlsphCNLR-LRRRhQhRp....-suusNhVHl+QKLYHNGHPSPR+L	.................lhGtshh.tIsClMDMNALLDRF.HNYILPHLRGEDRVCHCN.CG...RHHlHYVIPYDGDQSVVDuSENYFVTDNVTKQEIDLMLGLLLGFCISWFLVWMDGVLHCAVRAWRAuRRYDs.....SWoWLPKhCsLRELt+RsH...a...EEssGNMVHlKQKLYHNGHPSPRHL....	0	1	4	9
+15060	PF15208	Rab15_effector		Rab15 effector	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6BDI9	Family	This family of proteins has a role in receptor recycling from the endocytic recycling compartment [1].	27.00	27.00	78.90	78.60	17.90	16.80	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.77	0.70	-11.66	0.70	-4.91	2	26	2012-06-29 13:19:39	2012-06-29 14:19:39	1	1	25	0	16	26	0	232.30	61	97.83	NEW	MGQKsSQQls.pDSpEV.uhCEVVStAIsHAAQKlKEYLGFE.PLSpLC.AusoLsElFLlHFVTFCQ-+GsDEWLTTTKMTKHQAhLFGADWIWTFWGs-KQIRLQlAVQTL+MuSLP.s-PKsC.....ESRuEE.ShK+uRFDKLpEFCNLlGEDCLGLFIIFGVPGcPKsIRGVVL-SV+pthhpuQLsGRKAVtQFlLETcDClSI+ELLGNCLSK+DGLp-hG+VYIpIL	.......MGQKsSQQls.+DSpEl.slCEVVSpAlVHAAQKLKEYLGFEsP.S+LsPAuNTLNEIFLIHFITFCQEKGVDEWLTTTKMTKHQAhLFGADWIWTFW.GuDKQI+LQLAVQTLQM.....uShPP.sEucss.chsssES+....uE.EsSh+KoRF-KLEEFCsLIGEDCLGLFIIFGVPGKPKDIRGVVLDSVKsphs+upLPGtKAVtQFVL-TE-CVsI+ELLtNCLSKKDGL+EVGKVYIsIL........................	0	1	2	5
+15061	PF15209	IL31		Interleukin 31	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6EBC2	Family	\N	27.00	27.00	27.40	73.30	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.98	0.71	-10.63	0.71	-4.57	4	23	2012-06-29 13:20:31	2012-06-29 14:20:31	1	1	20	0	10	18	0	131.70	46	85.76	NEW	opohshtt.hsppDlp+hl-.Lpp.S+sLhcDYpccE.oGlssspshpLPChS.Dpps.sNI..SuIhAYLcpl+sLScpoV.hsclIcpLsclph.ss.psNISVP..TD.oa-CKsFILTlLpQFSsCMspl.tp.Noss	.........SHshPhthL.P.s.DlpKIlcELQsLSKhLLcDh.ccE...cGV.sSp.shpLPChosDuQsPsNIpSuAIhsYL+sI+p...Ls....s+oV.I-cIIEpLDKLh...FQcsPETNISVP..TD..oaEsKpFILTILQQFScCM-hshtuhsss..........	0	1	1	1
+15062	PF15210	SFTA2		Surfactant-associated protein 2	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6UW10	Family	\N	27.00	27.00	54.80	53.90	25.80	20.50	hmmbuild  -o /dev/null HMM SEED	59	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.85	0.72	-4.39	4	17	2012-06-29 13:21:16	2012-06-29 14:21:16	1	1	15	0	6	19	0	57.40	70	70.04	NEW	sGPGMTLQLKLKEoFLssSSYsSSFL-hLpKlCLLLHLPSGTNVTLHpAGS.HHVTCRs	......TGPGMTLQLKLKESFLsNSSY-SSFLELLEKLCLLLHLPSGTsVTLHHAtSpHHVsCps...	0	1	1	1
+15063	PF15211	CXCL17		VEGF co-regulated chemokine 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q6UXB2	Family	\N	27.00	27.00	32.80	32.30	22.70	19.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.88	0.72	-10.31	0.72	-3.59	6	23	2012-06-29 13:22:01	2012-06-29 14:22:01	1	1	20	0	12	17	0	89.40	67	76.13	NEW	SPNsGVARGHRDp+QAspRWLpEGGQECECKDWFLRAP+RKhhsV.GhP+KQCPCDHFKGphKKTR+Q+HH+.............Ksp+PSRsCQQF...L+pCp	..................SsNPGVARGHRDp+QAS+RWLQEGGQECECKDWFLRAP+RKlMT..VsGLPKKQCPCDHFKGsVKKTRHQ+HHR.............KPNKHSRACQQF...LKpCQ.	0	1	1	1
+15064	PF15212	SPATA19		Spermatogenesis-associated protein 19, mitochondrial	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q7Z5L4	Family	\N	27.00	27.00	74.00	28.90	18.50	17.80	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.62	0.71	-4.10	3	31	2012-06-29 13:24:21	2012-06-29 14:24:21	1	2	22	0	17	29	0	101.30	63	85.84	NEW	SSDIEVsESEAVSVVQHWLKKTEEEASRuIK.............EKMSTNsPPTHGQDIHVTRDVVKHHLSKSDLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEsp-DlMRDRIEQVRRSISHLoD-SuQDhShRsSsSEC	...............SSDl-VlEoEAVSVlpHWLKK..............TEEEASQuIK.............EKMShssPPTHGpDlHVTRDVVKH+LSKoshhus.SQEVLEERTRIQFIRWSHTRIFQVPSEhhp-hhp-RIEQVRRShspl.s......t.pss..pC....	0	2	2	4
+15065	PF15213	CDRT4		CMT1A duplicated region transcript 4 protein	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8N9R6	Family	\N	27.00	27.00	82.10	81.90	20.40	19.70	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.85	0.71	-4.08	6	29	2012-06-29 13:25:57	2012-06-29 14:25:57	1	1	21	0	14	25	0	134.80	61	89.10	NEW	cLTENIGLPlsLLEKHsPWPAYVTYhSPhVKRLIEKSKARDLEChpAlEcsp+su+QSKPSSlhQLKRRKSSKsSGphsLKDThSETMLSsWuuhSsssVuPohlPEPtpLHsDSREsPTuNYNKIIFuR+PhMRhLP	..............t.LTENhGLPhpLLEKHDPWPAYVTYTS.sVKRLIEKSKsRELEChpAlEEsp.hsSRQsKPSSlIQLKRRKSSKSSGcssa+DsLSEosLShWGsYSl.AhuPThlPEPT+lHoDSR-sPTpNYNKIIFuRKPhMRMLP..	0	1	1	1
+15066	PF15214	PXT1		Peroxisomal testis-specific protein 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8NFP0	Family	This family of proteins is testis-specific [1].	27.00	27.00	28.40	48.10	20.30	18.30	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.28	0.72	-8.64	0.72	-3.71	2	16	2012-06-29 13:26:47	2012-06-29 14:26:47	1	1	14	0	6	16	0	50.90	72	56.96	NEW	MQLRHIGDslsHRhlpEcLtQ-stDsLs.FVhhhFhRsQVLL+FFWNNHLL	.MQLRHIGDSIDHRMVpEDLQ.QDGRDALs+FVhFFFRRVQVLLHFFWNNHLL...	0	1	1	1
+15067	PF15215	FDC-SP		Follicular dendritic cell secreted peptide	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8NFU4	Family	\N	27.00	27.00	75.20	75.00	24.20	24.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.42	0.72	-3.67	2	10	2012-06-29 13:27:30	2012-06-29 14:27:30	1	1	9	0	1	10	0	65.10	68	77.32	NEW	hPVspDQEREKRSh..SDELspth.h.Pas.PFtshPPh...t.PWahh.a..Ph.lP..sPTT.hP	FPVSQDQEREKRSISD..SDELuSGFhVFPYPYPFRPaPPIPaPRaPWFpRsF..PIPIPESsPTTPLP	0	1	1	1
+15068	PF15216	TSLP		Thymic stromal lymphopoietin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q969D9	Family	\N	27.00	27.00	27.90	30.90	20.20	16.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.85	0.71	-4.40	5	25	2012-06-29 13:28:18	2012-06-29 14:28:18	1	1	18	0	10	23	0	101.00	53	84.64	NEW	YNFTNCNFE+IpcIYpslIF+DLpsYlNGhKSscFNphVsC-sRPuCLTKIEpaTFNPlsGCsSLAKKtFAp+TKAALssaCPGYSETQIN.uTQAM+KR...cVssNKCLcQVSQLLcLWRpFsR.....p	.....YsFosCsFpKIpttY.psI.psLhpYMsGsKSopFNpsl.Cps+spCLscIpphTFsPs.tCsSLucch...FAh+TKAsLslaCPGYSETQIN.uTQsM+KRhcccVssNKCLEQVSQL.GLWRcF.R..s....	0	1	1	1
+15069	PF15217	TSC21		TSC21 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q96LM6	Family	This family of proteins is testis-specific [1].	27.00	27.00	176.40	176.20	17.90	17.10	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.28	0.71	-4.60	5	23	2012-06-29 13:28:57	2012-06-29 14:28:57	1	1	21	0	15	23	0	175.40	72	99.63	NEW	MAGVVYPpQAPVDLDIYQSSYMVDYKPYGKHKYSRVTPQEQAKLDAQLRDKEFYRPlPsPNPKLEDGYPAFRRPHMTA+DLGlPGFFPPQ-HVTTsEDEsRFTSTC+olYPASHsLYLAQGDPNRl+QSADFPCLLEPERQPAsEVGKGYFLLPGCsCsYHppVKVPILNRWGPLMPFYQ	.........MAGVhYPtQsPVDLDIYQSSYMVDYpPYGKHKYSRVTPQEQAKLDAQLR-KEFYRPlPsPNPKLpDGYPAFKRPHMTAKDLGlPGFFPsQ..-+sATtEDEs+FTSTC+hsYPASHsLaLAQGDPNplpQSADFPCLLEPE+QPAuEhGKGYLLLPGCsCsHHp.hVKVPILNRWGPLMPFYQ.	0	1	1	2
+15070	PF15218	SPATA25		Spermatogenesis-associated protein 25	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9BR10	Family	This family of proteins may be involved in spermatogenesis [1].	27.00	27.00	127.00	126.90	17.50	16.60	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.59	0.70	-4.92	3	28	2012-06-29 13:29:44	2012-06-29 14:29:44	1	2	25	0	16	25	0	204.40	78	100.09	NEW	MSYFsSPQTHPGLLPSGQGGAASPGSSLGLYSPAEPVlVASGGQGPLSQKAEQVTPVAQAWGPALAV.EARGCPGGVSWEPPRRKEYNRYCHKhPsARQLESLGWEDuCSRSRAPaLGGPSRPpPLLLCGLSPGALPhPSEAGGKEAuSQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGAQWpQ..A+oHhASGPMALVRSRRGQPPGSCL	.MSYFhoPQTH.G.LPSGQGGAASPG.SLGLhSPsEPVVVASGGhGPLSQKAEQVsPuAQAWGPALAhPpARGCPGGsSWETL..RKEYu.RYCHKFPasRQ.ESLGW-DGsSRSRAP.cL.....GG.....PSRPtPLLLCGLSPGVLPhPSEAsGKEAuSQPDICILTLAMMIAGIPTVPVPGLREEDLIRAAQAFMMAHPEPEGAVEGspWEQ..A+A..HTASGpMPLVRS+RGQPPGSCL..	0	1	1	2
+15071	PF15219	TEX12		Testis-expressed 12	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9BXU0	Family	\N	27.00	27.00	31.30	30.80	23.10	20.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.19	0.72	-4.03	3	27	2012-06-29 13:30:40	2012-06-29 14:30:40	1	1	24	0	16	28	0	96.60	76	82.11	NEW	Ms-SP..QlSSLGK.....SDSShLESSGLFYK-EuLEKDLSDMSKEINLMLSTYAKVLSERAAVDASYIDEIDGLFKEANsIENFLlQKREhLRQRFTVIoNTLH+	........................PDSP..QLSSLGK.....SDSSFSEsS.GLFYKDEuLEKDLNDhSKEINLMLSTYAKlLSERAAVDASYIDEIDtLFKEANsIENFLIQKREhLRQRFTVIANTLHR...	0	2	2	2
+15072	PF15220	HILPDA		Hypoxia-inducible lipid droplet-associated 	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9Y5L2	Family	This family of proteins stimulate intracellular lipid accumulation, function as autocrine growth factors and enhance cell growth [1-2].	27.00	27.00	28.90	43.00	19.40	18.80	hmmbuild  -o /dev/null HMM SEED	63	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.55	0.72	-8.94	0.72	-3.99	3	15	2012-06-29 13:35:03	2012-06-29 14:35:03	1	1	15	0	6	18	0	62.40	76	95.12	NEW	MKaVLNLYLLGVVLTLLSIFVRVMESLGGLLESPSPGSSWTTRGQLANTEPTKGLPDHPSRGV	MKHlLNLYLLGVVLTLLSIFVRVMESLEGLLESPSPGoSWTTRuQLANTEPsKGLPDHPSRuM........................	0	1	1	1
+15073	PF15221	LEP503		Lens epithelial cell protein LEP503	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q9Y5L5	Family	This protein may be involved in lens epithelial cell differentiation [1-2].	27.00	27.00	27.80	44.40	21.80	21.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-9.01	0.72	-4.27	3	18	2012-06-29 13:35:43	2012-06-29 14:35:43	1	1	16	0	10	19	0	61.10	81	92.36	NEW	MQPpTQPLAQALPFSLRcALpDTGLRVPVIKMGTGWEGhQRTLKEVAYILLCCWCIKELLD	MQPRTQPLAQsLPFSLtGALRDTGLRVPVIK..M.GTGWEGhQRTLKEVAYILLCCWCIKELLD	0	1	2	2
+15074	PF15222	KAR		Kidney androgen-regulated 	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P61109	Family	The function of this family is unknown.	27.00	27.00	171.80	171.60	22.00	19.10	hmmbuild  -o /dev/null HMM SEED	103	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.30	0.72	-3.94	2	4	2012-06-29 13:37:42	2012-06-29 14:37:42	1	1	3	0	2	3	0	102.80	75	85.09	NEW	FP..-lsSINcELQsSIhDlLNSs.D.QLuSYcsopuP.ED.T.p-.sTD...hMphT.utshQ.SEhSsssETVSSuFLEEhTEso-.TVchPLA.ssshSsTS	FPLSELVSINKELQNSIIDLLNSVFD.QLGSYRGTKAPLEDYTDDDLSTDSEQIMDFTPAANKQNSEFSTDVETVSSGFLEEFTENTDITVKIPLA.GNPVSPTS	0	1	1	1
+15075	PF15223	DUF4584		Domain of unknown function (DUF4584)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A6NHQ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are approximately 835 amino acids in length. The family is found in association with Pfam:PF02437.	27.00	27.00	29.50	29.50	21.00	26.20	hmmbuild  -o /dev/null HMM SEED	397	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.55	0.70	-5.20	8	68	2012-06-29 13:50:24	2012-06-29 14:50:24	1	3	37	0	39	59	0	321.00	50	52.29	NEW	pPPlhhpssF+hpssssssspps....tssssGhDsppp.Kspss-ph.s.pthssuusssssPsSl..s.s.hppp............t.pssspRTD..........ss......oPsPptspsF.Ppp+h.......Pupsspsssus.ss.ss.pp............s.ssp.t+c.+hs.s.phsoslc+hp.-.........PpssucpsAcoPssh..s.s.PFpL+Nl+lKlE-....-EaEhthpssclpCcscsuctp..s...hKptD......p......stpcssu....s.s.......sLcsPss--Gtp+sss+..Ksh+s.l.tp+...t...ssA+sstKssRps+ssu+ossspto.t.............tht.h......sRRK+...AssssuPsKpsFSLMANFPsPPoLllGpDGDLsPAYSLNop+sspPPP.uHPlW+WQlGGsslP.PPu........pKhRKh	..............................................................s.ssh.hpssF.Yp.tsttt.pt........p.tt.....pp.ttpp...h.s..thsshss.h.p.suhssshschppc....t.....c.p..sssppTD..........................ss.t.ss.SPusppspsF.s.pRh.......htpspKC.psh.ss.sspsp...................................................................p.t+.s+h..s.ch......sosl.p.ps-s.................................tstssttsts..........t.PF.LHNlKIKlE-su..-EYE.ph.....spplKCcssssctph.s.st.cpp-hhh..thc............sppcssuh.s......hs.....ps.......sLsoPps--GEhK.sA+VpKNaRoLVLGK+..h.ps..sPsKsshKssRSPRPsuKo.............popEu.oLc.............shssh......sRRK+..sAuNs..sSssKpsFshMANFPCPPSLllGcDGDLhPAYSLNop+DSpPP..AHPlW+WQlGGsAlP.P.Pu........pKFRKa........	0	4	7	14
+15076	PF15224	SCRG1		Scrapie-responsive protein 1	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:O75711	Family	This protein family has an important function in acting against the prion protein, Scrapie [1,2].This family of proteins is found in eukaryotes. Proteins in this family are approximately 98 amino acids in length.	27.00	27.00	126.90	126.70	20.80	19.30	hmmbuild  -o /dev/null HMM SEED	78	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.35	0.72	-9.92	0.72	-4.16	2	33	2012-06-29 13:53:27	2012-06-29 14:53:27	1	1	27	0	19	25	0	76.80	81	79.22	NEW	hPupR.SCY++IL+s+sCHSlPEGhAsLp+lD.slQDHFW-GcGCEhlCYCNFpELLCCPK-lFFGPKISFVIPCNsc	.MPuNRLSCYRKILKD+NCHNLPEGVADLTpIDV.NVQDHFWDGKGCEMICYCNFSELLCCPKDlFFGPKISFVIPCNNp.......	0	1	2	5
+15077	PF15225	IL32		Interleukin 32	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P24001	Family	\N	27.00	27.00	69.50	63.00	22.50	18.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.71	0.72	-10.45	0.72	-4.09	2	18	2012-06-29 14:50:41	2012-06-29 15:50:41	1	1	7	0	1	29	0	92.30	85	50.78	NEW	E.TPLL.c.RptLRsRspRSsVPslED.uhE..-PtESFhD+shRhFQthLppLQphWpuVLAWV+chVs....ALspAVpAlWp.FQsFCs.luplhhSuhQu	.ELTPLLEKERDGLRCRGNRSPVPDVEDPATE..EPGESFCDKVMRWFQAMLQRLQTWWHGVLAWVKEKVV....ALVHAVQALWKQFQSFCCSLSELFMSSFQS...	0	1	1	1
+15078	PF15226	HPIP		HCF-1 beta-propeller-interacting protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NWW0	Family	HPIP is a small cellular polypeptide that binds to the beta-propeller domain of HCF-1. HPIP regulates HCF-1 activity by modulating its subcellular localisation. HCF-1 is a cellular protein required by VP16 to activate the herpes simplex virus- immediate-early genes. VP16 is a component of the viral tegument and, after release into the cell, binds to HCF-1 and translocates to the nucleus to form a complex with the POU domain protein Oct-1 and a VP16-responsive DNA sequence. HPIP-mediated export may provide the pool of cytoplasmic HCF-1 required for import of virion-derived VP16 into the nucleus [1].	22.10	22.10	24.20	22.10	19.20	17.80	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.66	0.71	-4.05	9	35	2012-06-29 14:59:46	2012-06-29 15:59:46	1	1	28	0	17	37	0	118.50	66	81.84	NEW	ILQQPLERGP.GtAQRDPRAAoGsohGLDs...................REPLRKQFLSEENMATHFSRLSLHNDHPYCSPPhsFPP.ALPPLRSPCSELLLWRYPGsLIPEALRLLRLGDTPoPaYPAoPAG-	......................................ILQQPLERGP.GtsQR.PRAA.GsotGLDAs........................pEPLRKQFLSEENMATHFScLSLHNDHPYCSP..PhsFP...P.ALPPLRSPCSELLLWRYPGsLIPEALRLLRLGDTPoP.YPAoPAGD.....................	1	3	3	5
+15080	PF15227	zf-C3HC4_4		zinc finger of C3HC4-type, RING	Coggill P	pcc	manual	Domain	This is a family of primate-specific Ret finger protein-like (RFPL) zinc-fingers of the C3HC4 type. Ret finger protein-like proteins are primate-specific target genes of Pax6, a key transcription factor for pancreas, eye and neocortex development [1]. This domain is likely to be DNA-binding [2]. This zinc-finger domain together with the RDM domain, Pfam:PF11002, forms a large zinc-finger structure of the RING/U-Box superfamily. RING-containing proteins are known to exert an E3 ubiquitin protein ligase activity with the zinc-finger structure being mandatory for binding to the E2 ubiquitin-conjugating enzyme [3].	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	42	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.27	0.72	-8.66	0.72	-4.08	13	3078	2012-10-03 15:03:13	2012-08-03 15:33:49	1	84	232	5	1547	3331	31	42.10	42	9.14	NEW	CPICh-YLccPsolpCGHsFChsCIsshpc-scut....hhCPhC	.....CsICL....-.hh....p..-.....PV.o.l.s.C.GHsFCpsC.l....p...p...h.......a...p...p.....t....p...t.t..............hsCP.C....................	0	267	479	886
+15081	PF15228	DAP		Death-associated protein	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A0PJW8	Family	\N	27.00	27.00	31.40	30.90	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.84	0.72	-10.73	0.72	-3.26	49	159	2012-08-06 10:09:36	2012-08-06 11:09:36	1	2	102	0	88	149	0	90.50	37	87.26	NEW	KuGHPPAVK.AGGMRIs.p++.........t..pscpcp.psc.sppcs.hpphssss.h.......lhloGslsKts+DFP...spAspshH.p....KPpPul-ptsss...pth....h...............pQPRK	....................KuGHPPA...VK.AGGMRIs.pKp..........sscpcpppp.ttppp..ps.ssss.h.......shloGslsKhs+DFP...ssuspsAH.p....KPpPul-Khsss....cp....I.....QQPRK.........................................................	0	22	29	56
+15082	PF15229	POM121		POM121 family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A6NNC1	Family	\N	27.00	27.00	27.50	27.20	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.76	0.70	-11.36	0.70	-4.93	32	248	2012-08-06 10:20:27	2012-08-06 11:20:27	1	5	42	0	92	193	0	179.20	33	32.00	NEW	L+Es.t++ss.ccE-.hhs-u.......-s+RRps-ostpu.SAFcPLhssGs.uSFVP+PGsLKRulpspsS-cshsK.RSpsSShSSh..ssh.sthP..opRNAIoSSYSSopGhsphh..KRs.........suoopsQhPcpPsKKtpcc...tpp..s...ssPhhosp..ttt............s..p..s..sussosuuStp.++.....RKlPLL..ssppG-.LsLPPPPQLGasVTsEDL.-LEKKAulphhNpsLEs	.............................................................................................................p...t...p.c-.h..pt.......psp+p..psstt.h.Ss.cPL.tpGs.sshhspP..tsLptsh.pspp.o.-.p.sp.+upsS.hSSh............spRNAIs..SSaSSotGhsthh..+Rps...............Puoupsphs.psuKphpcc...............ss.hssst...ptptc+......ss.sshpp.s.tsu.s.pst..uSt..p+......+.K..h....Ll..........pttt-.l.LPPPspLGa.lstcDl.sht+cuthph.pphh.................................................	0	25	28	36
+15083	PF15230	SRRM_C		Serine/arginine repetitive matrix protein C-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A7MD48	Family	This domain is found near to the C-terminus of Serine/arginine repetitive matrix proteins 3 and 4.	27.00	27.00	30.50	30.50	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.03	0.72	-9.59	0.72	-3.89	14	73	2012-08-06 10:34:30	2012-08-06 11:34:30	1	2	35	0	39	59	0	67.70	64	12.36	NEW	hSt.p+p...sRE+-pcscspc.pcsctsRtRRRpRSYSPl..RKRRRDSPSahEsRRIT.......SA......RKRPIPYYRP	......................................hS+ao.....uRERDschpp+c.pppc+pR.ARRRRRSYSPh..RKRRRDSPSHLEARRIT..........................SA...RKRPIPYYRP...........	0	3	5	16
+15084	PF15231	VCX_VCY		Variable charge X/Y family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O14598	Family	The variable charge X/Y (VCX/VCY) family of proteins has members on the Human X and Y chromosomes, is expressed in male germ calls and may play a role in spermatogenesis or in sex ratio distortion [1].	27.00	27.00	43.00	28.30	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.17	0.71	-3.80	5	104	2012-08-06 10:46:14	2012-08-06 11:46:14	1	6	8	0	12	91	0	92.90	61	104.49	NEW	MAPKhRASGPPAKAKETRKRKSSSQsSPSoPKK....sPKlAKKGKAuRGGRGGKKRAA.cKM..AAVsAPEAGSGPAPPGPScPPSQELPQHEL.P.PEEPVSEGTQPDPLSQETQL....................EDPLSQETQlEEPLS-tt....lpps.p..opl.p.........-PLS	.............................................................................................................................-PLSQEoplEEPLSQEoplEEPLSpEop.lE-P.pQpoph..................................	0	12	12	12
+15085	PF15232	DUF4585		Domain of unknown function (DUF4585)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:E7EW31	Family	The function of this protein domain family is yet to be characterised. It is putatively thought to lie in the C-terminal domain of the DNA nucleotide repair protein, Xeroderma pigmentosa complementation group A (XPA). The function of XPA is to bind to DNA and repair any mismatched base pairs.  This domain family is often found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved DPE sequence motif. In humans, this protein is encoded for in the chromosomal position, Chromosome 5 open reading frame 65. Mutations in the gene lead to myelodysplastic syndromes, where there is inefficient stem cell production in the bone marrow. This suggests that the protein may have a role in forming blood cells [1].	27.00	27.00	36.70	39.10	22.90	18.70	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.23	0.72	-9.68	0.72	-4.12	13	64	2012-08-06 11:01:28	2012-08-06 12:01:28	1	2	28	0	39	60	0	71.60	48	6.08	NEW	pssassTQ+KlL.DPcSGcYalVDhPl..Qs+hKphaDPETGpYVcVslPsSttu..tssss.shs.uPhsLhPuhaPs	...p.shstTQtKlLlDPpoGpYYlVDsPl..QPph+pLFDPETGQYV-VslPs.sp.s...shssh.hs.sPlALuPGhYss.........	0	3	9	13
+15086	PF15233	SYCE1		Synaptonemal complex central element protein 1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:A8MT33	Family	This family of proteins includes synaptonemal complex central element protein 1, a component of the synaptonemal complex involved in meiosis, and synaptonemal complex central element protein 1-like, which may be involved in meiosis [1-2].	27.00	27.00	27.20	27.20	25.20	25.20	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.83	0.71	-4.23	17	64	2012-08-06 11:54:32	2012-08-06 12:54:32	1	2	29	0	32	68	0	134.00	58	50.35	NEW	tGSLEPpIE-LIsRIN-LQQ...AKKKusEELGEspslh-ALp+ELDSLsuEKlHLEElLs..KKQEsLR.ILQLHCQ-KEoEuphp............................RhcF...Ep.QLEpLhpp...........HKcL......WEF+h.sppLupEIssl-su..KEQLLpE	.....................................GSLEPplEsLINRINElQQ...AKKKusEELGEApslhEALp+ELDSLpGEKV.+LcElLs..KKQEsLR.ILpLHCQEK.......ESEApRp..psh...h.....................RLsFEE.QLE-LMGQ...........HKDL......W-FHh.sc+LA+EIssL-SS..KEQLLpE.......................	0	2	3	5
+15087	PF15234	LAT		Linker for activation of T-cells	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O43561	Family	\N	27.00	27.00	28.90	36.50	23.70	23.70	hmmbuild  -o /dev/null HMM SEED	230	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.73	0.70	-4.88	10	45	2012-08-06 12:03:20	2012-08-06 13:03:20	1	2	25	0	17	36	0	221.60	68	95.17	NEW	MEsslLl.PssLGLLLLPLLAVLLhALCVRCRELPG..SYDSA..........ooDSLaPcSIlIKpPt...TluPWPPAs.Ys.VTSaPPLSQPDLLPIPRSPQPPGGSHRMPSSRQDSDG.ANSVASYENE...........................EPACEDsDEDEDEEDYHNE...GYLlVLPDSoPATSou....VPs.APVPSNPGLRDSAFSMESG-DYVNVPESEESA-ASLDGSREYVNVSQELQP...sARTEPATloSQ.......ps---EEEsAPDYENL..QE	...........MEtshLl.PslLGLLLLPlLAh.LhALCV+C+cLPG..SYDSs..........SSDSLYPRu.I.lK+Pp...TlsPWPPAh..P.VTSYPPLSQPDLLPIPRSPQPLGGSHRhPSSRpDSDG.ANSVASYENE..............................................EP.ACED.-tD..EDEDDYpN....GYLVVLPDSoPAoSou....ssu.APs.SsPGlRDSAFSMESh-DYVNVPEStESA-ASLDGSREYVNVSQELpP...sA+TEPAslsSQ.......Et.-psE-EtAPDYENL..QE...........	0	1	1	2
+15088	PF15235	GRIN_C		G protein-regulated inducer of neurite outgrowth C-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O60269	Family	This represents the C-terminus of the G protein-regulated inducer of neurite outgrowth proteins [1].	27.00	27.00	63.80	59.70	20.30	19.30	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.46	0.71	-11.10	0.71	-4.09	16	86	2012-08-06 12:19:08	2012-08-06 13:19:08	1	1	34	0	51	88	0	133.70	48	21.15	NEW	+SVATuPhpss.............s...pststsa...............PEVplc.........s.pcspp.PVR-VsWDEcGMTWEVYGASlDsEVLGhAIQKHLEhQIEpa..QhtP.....st.t.pts.....................ppssspppt+Rps...FRshhpslR+PsCCsRuusss..E	...............................................................+uVtsuPhhst.................sutsthh...............Ppsphc.............s..ctspPVRDVsWDEcGMTWEVYGASlDsEVLGlAIQKHLEpQIcEatcphts.....t.....ts........................................................p.spssspttt+Rt.sh.FRuhlQslRRPsCCsRuusu..............................................................................	0	4	9	16
+15089	PF15236	CCDC66		Coiled-coil domain-containing protein 66	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A2RUB6	Family	This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure [1].	27.00	27.00	27.00	27.40	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.37	0.71	-11.18	0.71	-4.61	19	118	2012-08-06 12:25:34	2012-08-06 13:25:34	1	2	69	0	69	126	0	148.20	35	16.22	NEW	sssssttspsspptpsspsspssshps.p....p.saLRuhoA.LLDsup.....lpER-cRRpKthEaQcAIttQlEE+c+hKphEcpp+ppEEppEEpRltRE+pphpcpaEc-hhcp+pKEEhhppKTptLhpshp+ApEhApc.K.pc......................pRh+cltpcsc-hpph	..............................................................p.......tptp......saLRu.ss..lDstp.....ltE...R-c+RpKQhEappAlptQlEEK+p++phEcEp++pEEpcEE..pRLAc-Rp.chQcp..aEE-hh.+p+pKEEh......phKspcL....hpshpcApc.Ap+hK.pc................................................pRh+chtpctpt....h.......................................................	0	20	24	41
+15090	PF15237	PTRF_SDPR		PTRF/SDPR family	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:O95810	Family	This family of proteins includes muscle-related coiled-coil protein (MURC), protein kinase C delta-binding protein (PRKCDBP), polymerase I and transcript release factor (PTRF) and serum deprivation-response protein (SDPR). MURC activates the Rho/ROCK pathway [1]. PRKCDBP appears to act as an immune potentiator [2]. PTRF is involved in caveolae formation and function [3]. SDPR is involved in the targetting of protein kinase Calpha to caveolae [4].	27.00	27.00	28.60	28.10	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	246	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.65	0.70	-4.97	30	215	2012-08-06 12:39:37	2012-08-06 13:39:37	1	2	43	0	103	180	0	216.10	41	68.95	NEW	QlsAlTVloLLDKlsshlDsVQpsQpphEpRQt-hEsu....V+sIQu-lsKLo+uHssTSsTVsKLLEKsRKVSsplKsVRsRl-+QusQVKKLEsNcscLL+Rs+F+VlIaQ-EsElPuplsspp.psh......................t.t..t.....pch.tshcL.SSDEE..h.l.............................p.hEESRAcRlKRSuL++VDsLKKAFS.........................................................................Rp..................sl-KKhs+luT+I.VsPERREKI+......cKShpss+t.stc..KposhKlsPh	...........QlsulhVloLLDKlhshlDplQtsQtphEpRQ..tphEsu....VpuIQs-LsKLo+uHssTSsTVsKLLEKsRKVSspsKsV+tplE+QssQlK+LEsNcscLL+RppF+VlIa.Q-EsclPupl.hpt.t.h............................t..s.ptpt.cct.tshpLSSD--.h.l...............................-ESRAp+l+RSuhc+VDslKKAFS....................................Rp..................sl-+Khs+lsT+l.VssERRE+h+........pShp..+...tp..Kps..pssP.........................................................	0	4	15	39
+15091	PF15238	FAM181		FAM181	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:A6NEQ2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 426 amino acids in length.	29.00	29.00	29.00	29.00	28.90	28.90	hmmbuild  -o /dev/null HMM SEED	297	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.20	0.70	-4.35	20	80	2012-08-06 12:48:17	2012-08-06 13:48:17	1	5	39	0	48	70	0	248.20	35	73.36	NEW	tsscpss+sLLsFls.ASSsIKhALDKsu.s+RpVsHRKYLQKQlKRhSthhsthP.t....Pspsspsps...+...tstststp...pspssspppustus.........shp.........pcSLuu.......................................t.h.tt.s.s...scp.VPLR+RsLPsSFapEP.....psspsh.....sussssslss...............scsschh-lLGP-..................sshsscps.h..ss...t...olss+..ssshss.....sPh.acupslhtu...hstsh....s.....sssshssls.hp..ss.s...........sscshp.sttss..up.hh.pssl.cs.sspsu	................................hsscpss+.LLsFls.ASSsIKhALDKsu.s....+RpVsHRKYLQKQlKRhSthhuthP.s............Pspssts.h.......+........us.ts........s.ht..h.s.ssspp.ustss...........tsshp.........pcsLut......................................tt..ttpsstu....stpVPhRpRpLPsSFapEP......p.spuh......sG.psuLss........cutcsschhE.LGP-...................ts..tp-shhh.ss.......uhssh..sss.ph.....pPh.acspshhsG.....s...sh......s.s.hssLsh.+..ss.............shc.ha.sttss..up.........................................................................................................................................................................	0	12	15	25
+15092	PF15239	DUF4586		Domain of unknown function (DUF4586)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:A7E2U8	Family	This protein family, refers to a domain of unknown function. The precise role of this protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 256 and 320 amino acids in length. There is a single completely conserved residue, phenylalanine (F), that may be functionally important. In humans, the protein is found in the position, chromosome 4 open reading frame 47.	27.00	27.00	27.00	31.40	26.80	26.20	hmmbuild  -o /dev/null HMM SEED	302	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-12.38	0.70	-4.87	41	143	2012-08-06 12:48:46	2012-08-06 13:48:46	1	5	80	0	94	135	0	260.60	27	87.27	NEW	csch-RhGLFS-.sa......lolGDpYhp.tpp......scssscsKpMLsuusKpts.shpsuYFs.pahplhpGEsY........tD.s+hcRphclcptKK..slu.KsFhPusGtKp.s.GhGsaaGsass.h...h........hss.p+spcthh.sts+........NhhTNPuK+Go.aGYsslTlup...sass..DsY-pt+chtccctpc+cphh......cG.ssF+h..shaspcaFDss.Pa.........h........pppsl..sPhcp.t.ttpphstP........FKPosP.....sc..t......ut+sGsFss.aPpapsDPhs.chpp..t..hpspp..............tt+hF+PssssK.o........pPssSIhstslp..+ph	.....................................................................hhGlFSp.sa......lsl.G.....DpY.p.htt.......tstsps+phls.s...ssKp.h...phpsuaF-.pah.plhpG-sY........hs..........p..hp+ptthcptKK.........sls.psFhPss..s.Kcss.GhGsaYGshst.h...h..............hsstt+spcthh....s.s+..............NlhTsPuK+Go.YGY..ss...l..slup...pat..........-.Y-ttc...cpppppccphh......hu..ssF+....shhstt...hFDts.sh........h.............ppsh....s.pp.....ph..ht.s........a+P.pP.....s...t...........uhhtGshs...aPpa.tDPh.ht.tp........pt...............tc.ahPssssp.s........h...Sl..........h.................................................................................	0	50	62	78
+15093	PF15240	Pro-rich		Proline-rich	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P02810	Family	This family includes several eukaryotic proline-rich proteins.	27.00	27.00	28.10	27.00	26.50	26.90	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.38	0.71	-12.12	0.71	-4.18	16	217	2012-08-06 12:57:24	2012-08-06 13:57:24	1	10	16	0	45	325	0	107.60	39	99.71	NEW	MLlILLoVALLALSSAQs.sE-VupE-ssSllu.....tt...........tsps.t.spp.Qt...........PP.GG..spsP...........................................................................................P.sGGPQp.pPPQsGp....................PpGPPP.GG...........................................ts.......tp.QGPPPQtGsp.....tPP.Ps......................pPQGPP....................t.........................s.sGss...................QtPPP.........PPsGpPQG..PP........................tPPQsG.pPptPPQ	.................................................................................................................................................................................................................................................................s..t..tsQt..PPpsGp..............pGPP.PQGs.sp.......t..sspP.....Gp.QGPPPQGGsQ....tPP.ss.........pPpG.PPsQt...s.........................................................................................................................................................	0	21	21	21
+15094	PF15241	Cylicin_N		Cylicin N-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P35663	Family	This is the N-terminus of cylicin proteins, which may play a role in spermatid differentiation [1].	27.00	27.00	31.90	30.20	25.30	25.30	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.95	0.72	-10.40	0.72	-4.18	22	69	2012-08-06 13:08:30	2012-08-06 14:08:30	1	1	23	0	27	48	0	108.90	52	24.53	NEW	QclNhsTYDNhIPlSE.S+KSWNQpHFuLsFPKPPpPG+K+RS+PSpLp...sVP....+p-ccKlccspKs..lWh++SLh+I.pRPSlYLAsRRQs.Ph+.shsspscscpApsc	...................cVNhtsYDN.IPlSE.S+KSWNQpHFALsFPKP.pPGpK+RS+PSplp..TVs....hhDccKLcpspKs..lWh++SLh+I.pRPSlYLAAR+Qs.Ph+.sassKscsKpAE.......................	0	2	2	3
+15095	PF15242	FAM53		Family of FAM53	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q14153	Family	The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation [1]. It is known to be highly important in neural tube development [2]. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.	27.00	27.00	28.70	27.60	24.00	24.00	hmmbuild  -o /dev/null HMM SEED	314	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.34	0.70	-12.39	0.70	-4.88	20	155	2012-08-06 13:28:35	2012-08-06 14:28:35	1	2	41	0	67	126	0	256.80	38	76.63	NEW	MVhllTcpLpppuh...DDlss+ohshs..apsccho.pussLFshsls..-s..pWpslstsssl.....ptcss...usShtshhssh.t......h..tuhpW.........p.-uss.ssslouLlpcLSLs....-ssu.....sPsAPPSKRpCRSLShsDELupC.RSsWRPtGSKVWTsVcKRRCpSGGSlphts.......p.tsG.sshQRSoShSLPupus......h....hspt..h..shsutss.sssstuupsss......t.t.hs.pRpLSLSpEpl.shsc....suAs..SoPsSTPELuRRsGt.......LsRSRSQPC..VLsc+KsuhKRRRsEDs+hpRPSLD..hsKMTQ	.......................................................................................MlhllocpLpppsh...Dpltpptht.t........scphs.pussLhshtl....-s.s.W+sLs.ttssh....p.pts...s.sh...................u..W.........p.puss.sst.pshhpsLshp............-pts.....................sPsAP.PoKRpCRSLS.s-E.hu..psRosWRPtuSKVWT.PVpKRRCtSGGSsph.p..........ss..thpp.pshsLPppss.hs.........h.pt.hh..s.t.tsu.hs...supusps.u....s..t.s.hs.pRphSLSpEph..phsp.......PSAs................SoPsSTPELsRRtu........L.RsRSQPC..VLss+KsthKRRR.EDs...p..pRPSLD..hhKMsQ.................................................	0	5	10	25
+15096	PF15243	ANAPC15		Anaphase-promoting complex subunit 15	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:P60006	Family	This is a component of the anaphase promoting complex/cyclosome [1].	27.00	27.00	30.50	37.60	26.80	26.00	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.53	0.72	-3.92	25	114	2012-08-06 13:34:13	2012-08-06 14:34:13	1	2	81	0	67	91	0	93.20	45	78.43	NEW	Ms.....shFPsLhPRls-shWFsl.D...............cPCsEEsELp.........p.EQpHQsWLpSIuc+sssLlPIGKsssE.............pct-s---....-sp--s..-csEptpp-p-Eh--h	........Ms..shFPSLhP+lT-oLWFNl.D...............+PCsEEoELp.........ppEppHQsWLpSIuc+ssNL...lPIGKPsoE................tp-c--pD-E....-s--Du......--sE-..pD.DEhsD.......................	0	11	20	40
+15097	PF15244	HSD3		Hydroxy-steroid dehydrogenase	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9P0W8	Family	This family also goes by the name of Spermatogenesis-associated protein 7 or SPAT7. It is an aldo-keto reductase (AKR) human type 3 3-alpha-hydroxy-steroid dehydrogenase (H3-alpha-HSD3, AKR1C2), and it plays a crucial role in the regulation of the intracellular concentrations of testosterone and 5-alpha-dihydrotestosterone (5-alpha-DHT), two steroids directly linked to the aetiology and the progression of many prostate diseases and cancer [1,2]. Mutations in the gene cause Leber congenital amaurosis (LCA) and juvenile retinitis pigmentosa (RP), the most common hereditary causes of visual impairment in infants and children [3].	27.00	27.00	28.10	27.50	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	419	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.72	0.70	-12.49	0.70	-5.23	10	108	2012-08-06 13:52:06	2012-08-06 14:52:06	1	3	48	0	44	107	0	234.10	43	66.25	NEW	+VRuosVLPRYuPPCLFKGHLSTKSNAFCTDSSSLRLSTLpLlKNHMAVHYNKILSAKAAVDCSVPVShosSIKYADQQRREKLKKELARCEKEhKLoKouhQANSKssSKSlhNoLQKPuGEPQsctshllEchNpFsSFu+SllsSSE+LcLu.LsKSscslosGocKNuSSS.oSh.............-hssSsPR+ssSussauR...+PRSshssSHR.FQLVlSKAPSGDLLDKHSEhFSNKQLPFTPRTLKTEAKSFLSQYRYYTPAKRK.KDhoDQcIEAETQTEL.SSF+S-hsTAEpKshT-SElNIpQA..SsCsTaGTK-KhsPhstptpsLsW-cl.K-ssLQpSSsRu.lCpYSlQ..Pus+KIaS-EEELLYLSFIEDVTDEILKLGLFSNR.FLERLFERHI+QNKHHLEEcKMRHLLHlLKVDLGChS	................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................p....t..c.......-EhhYlpFhtslTp-llphGlaos+..LpplFcpHlppp+.pLpttph...h..Lp.p..................................................................................	0	11	13	27
+15098	PF15245	VGLL4		Transcription cofactor vestigial-like protein 4	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14135	Family	These proteins act as transcriptional enhancer factor (TEF-1) cofactors [1].	27.00	27.00	28.30	27.20	24.00	25.90	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.90	0.70	-4.50	18	112	2012-08-06 13:52:32	2012-08-06 14:52:32	1	2	63	0	55	101	0	186.70	47	66.05	NEW	LLNaQYLDKM.NNNIG...lLpYEG....pstLRuEsRhpoLs......................thoscRTuPPPlsPoKRKhSt-QuDsch-p-s-HhoKMSRhFusp..Lsp....s.st-..Rpc......php+u+......SPh-phsss.o.ulhus.HlYuoh............sshu.hDQPLAL.TKsoh.-us+o.....tthsspssssER.QNRPSVITCAPAssRNCNLSHCs..shsusss....s.++.s....sTuCDPVlEEHFRRSLGcNYKEs	...........................................................................................................................................h....ht.......pt..............pstL+.u-sRhpsLsh.....................shospRTsPPPlsPsKRKhSh-.uDpch-p-s-HhoKMSRhFss+..Ls+....ssNGDp.Rc-.........R-RSR..........SPIER.usus.ohoLHus.HlYsSh.................h-QPLAL.TKNSh.-uuRs......ths.shsssERQQNRPSVI...T.CAsAs.sRNC..NLS.HCs.hsHsuCss.hss............................t.ssssssCDPVlEEHFRRSLG.KNYKEs........	0	9	14	35
+15099	PF15246	NCKAP5		Nck-associated protein 5, Peripheral clock protein	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:O14513	Family	NCKAP5 is short for Nck-associated protein 5, which is also known as the Peripheral clock protein. NCKAP5 is a protein family, which interacts with the SH3-containing region of the adaptor protein Nck. Nck is a protein that interacts with receptor tyrosine kinases and guanine nucleotide exchange factor Sos. The role of Nck can be thought of as similar to Grb2. The role of NCKAP5 is to assist Nck with its adaptor protein role [1].	27.00	27.00	82.30	38.30	20.80	20.60	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.26	0.70	-5.05	20	107	2012-08-06 13:52:54	2012-08-06 14:52:54	1	2	37	0	48	83	0	261.60	41	20.62	NEW	slpsoIEEKVMhGIpENVpKsQtQsKu.sosEsKQKsuPSlASWFGhRKSKLPALSuRKsDsuKsK-EKK-hKhhuhssppthscc++ccKctppphplss.hs+sp-htc..p.-puhhspps.cpspcstsp.........hppttpph.s.sstsspDsFMpELLNRVDcKsstpscpssspsshpshp+uSspupsh.ssshuspusp++.hps+hphptsppsh......htpts-phpc-Epss.sDos....hQsHhlsSusQhRTLDSGIGTFPLPDSssRusuRpsspppps.cp-s.sshp.shsssssl.+....ApTLEREVPSss	.............................................................................................................................................................................s..pssIEEKVMhsIpENV.+hQsQp+u.susEsKp+s.ssShASWFGh+KS+LPALs.R+h-soKsK.t....thhu....s.pp..schctc.Khtt.phplpp.ht+spc.tc..p.-puh.spps..pspshhst.........ht...tph.u.ht..stDsFMppLLN.R..VDtKth..pp.tpspsphtsh..soopsps...suhuspss....hhs.hphpt....th.......................ssEshpc-E.ss..-sh.....psHhhtsss.hRTLDSGIGTFP.PDpGsp.ussph.h.tsps.ch-s..sl.su..t.sssh.+....ApTLEREVPu..p..........................	0	2	5	16
+15100	PF15247	SLBP_RNA_bind		Histone RNA hairpin-binding protein RNA-binding domain	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14493	Family	This family represents the RNA-binding domain of histone RNA hairpin-binding protein [1].	27.00	27.00	37.20	39.80	26.90	24.30	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.04	0.72	-9.61	0.72	-4.21	52	232	2012-08-06 14:32:12	2012-08-06 15:32:12	1	2	135	1	151	227	1	76.20	47	23.06	NEW	hEsD.p......pLtpRQKQ....I-aGKNThGYppYlppVP.+ppRp..p.....tHPpTPsKapphSRRuWDupl+hWR+tLHp.a......D...........Ps	......................EpDpp....hLtpRQKQ....IsYGKNThuYc+YlctVP.+c..tRp.......shHPcTPsKap+hS+RuWDtpl+lWRptLHh.aDs........................	0	62	84	119
+15101	PF15248	DUF4587		Domain of unknown function (DUF4587)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:P58505	Family	This protein family is a domain of unknown function. The precise function of this protein domain remains to be elucidated. This domain family is found in eukaryotes, and is typically between 64 and 79 amino acids in length. There are two conserved sequence motifs: QNAQ and HHH. In humans, it is found in the position, chromosome 21 open reading frame 58.	27.00	27.00	44.40	44.40	19.90	19.30	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.13	0.72	-3.38	28	70	2012-08-06 14:40:19	2012-08-06 15:40:19	1	2	34	0	36	68	0	68.60	47	28.36	NEW	RsGuI..KEDMVEhMLhQNAQMHQllMpshMl+ALPPhs....s..................stssslcspc.....pcPssVHHHHaa	.......+sGplKEDhVEhMLhQNAQMHQllhpNhML+ALPPs.s....st........p....s...p.hhhcspc...pcPssVaHHHa................	0	4	7	14
+15102	PF15249	GLTSCR1		Glioma tumor suppressor candidate region	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NZM4	Family	This domain family is found in eukaryotes, and is typically between 105 and 124 amino acids in length. There is a single completely conserved residue F that may be functionally important. Mutations in the gene for this protein in humans leads to the development of oligodendrogliomas [1]. There is evidence that these protein interacts with SH3 domains [2].	27.00	27.00	27.60	27.40	26.90	26.60	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.51	0.72	-3.95	54	193	2012-10-03 11:11:44	2012-08-06 15:41:14	1	6	115	0	126	197	0	109.40	33	10.45	NEW	htpphttcptt.......shpP...........Dh.p...sPFpo..hpDAlcRL..LPYHlhtp.p.s..........pDhpt........................hDcp......hcspssp.h..hp+hpphhp+aphllhccut......cts...spEtlh...lpphhhp-E+pplpc	...............................................hppLppcpst....................shpP...........Dh.poPFpShcDAlpRL..LPYHVhpss.sst.................pDhpp.......................................................................hDpc......aEshusp.h..hc+hpthlsKaphlLhc-uh......chss..osEhlM...l-phhlp-E+tplt............................................................................	0	38	57	88
+15103	PF15250	Raftlin		Raftlin	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14699	Family	This family of proteins plays a role in the formation and/or maintenance of lipid rafts [1].	27.00	27.00	30.90	41.60	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.62	0.70	-12.61	0.70	-5.96	19	145	2012-08-06 14:45:02	2012-08-06 15:45:02	1	6	38	0	65	124	0	348.00	40	86.42	NEW	MGCGLRKLEcsDDsSPGKIaSTLKRPQVETKsDsAYEYhhLDFTl..pu..ss.sssl+luSlhDlPsplp-hYpQGalluAlHPhlpPsscpcplPtpplaRAlLl+hp.p..ppcss.hspct.pLhlEECs.stcshss-hlppLIcK.lp-AAcpGh+FVGhl.........spths.spssssos....sstsh-.c.s..........................................tthcpss-css+s.......spush.sspss-suhcpchptpss......h.......ss.s.sp.........ch+LaslFNt.c......c.spsChpYapsslsh+VoRpGpslSoL-AsWLEhhohaa+pG.hSLVDuasphshs+.Dpls+sl-GlFIaEEtuousstosp.G.DAIVVEQWTVIEGsEVKTDYsPLLpoLApFGWhLTCVLPTPIl+ps.SEGNLATKQlVFLQRPsh.pp..stpp.p..........cppsRph+p..cpppsuscp.s...tp..ssE	...............................................................MGCtL.KLc.c.--.p.pPGpIaSTL+RsQVET+ht.sYpYhhL-F.h....tu..stspslplsSlh-lsspl.-hY.pGa.lsAlHPhlpPsttpcphP.phlaRslL...+.p.p...ppp.ss..tpp..t.hL.l-pCs.h.p..spchh.thlcK.lp.uAppGh+FVGhl.........................p.hs..t.ss.ss.........p....................................................................t.....................spsp...s.t.p..pthp..pp.pt.pt..............t..p.shst.........c.claslFNt.c......s.pppshpY..shlsh+Vo+pGps.losL-AsWLEhho.aa+pG.h.Llsuhhhhth.s.p....-p.h.t.h-GlFIaEt.ustssto.p.G.DAIVVE.QWTVlEG...sElpTDYsPLLpoLAtaGW.LTsVLPTPll+ps.pEGsluTKQlVFLQRPsh.pp..htpp.p..........cht.t+..pt..t.t..sttp.t..........tt...................................................	0	3	9	26
+15104	PF15251	DUF4588		Domain of unknown function (DUF4588)	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q14CZ0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 274 amino acids in length. There is a conserved LYK sequence motif. There is a single completely conserved residue A that may be functionally important.	27.00	27.00	27.20	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.82	0.70	-4.38	18	156	2012-08-06 14:50:59	2012-08-06 15:50:59	1	2	115	0	102	137	0	208.80	31	89.72	NEW	EppCl..s-up.ccp..........................t.pssphpsppp+LWptFpsuAsAVApLYp...................t...................t.thohWssFpsAAtuVTsLYK-Ss.DuppRSh-hGhpsGhpc......Rs+DllpWs+.+tRphIRRE-LluaLsG+sPPs......+s.sps..............sscs........ss..sssp.....p..ts.t.s.s......l-ssLpsF+-AluLtt..hsshhsshuh.susPsossp.pt.t.......................uhpcscLsshhs...--lshp.............pRKRppspss-s.............sSPoHKRsR.hh	........................................................................t....t.....pplh..FptsApulApLYp.........................tp.shuLWssFQsAAsuVTsLYKpSs.-spp+oh-hGhphGhpc............................cs+-lhsWs+.KpR.ph..IRRED...LluaLsGKssPs......ps..pt.............................ssp................st.......t.....tssss........spsshp.sh.ppsluh.....st.hss.phtss...Ps.sst....t.............................t...............tpht.................p...t.............................h.......................................................................................................................	0	24	37	70
+15105	PF15252	DUF4589		Domain of unknown function (DUF4589)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q2T9L4	Family	This protein family is a domain of unknown function. The precise function of the protein domain remains to be elucidated. This family of proteins is found in eukaryotes and are typically between 215 and 293 amino acids in length. The protein contains two conserved sequence motifs: SSS and KST.	27.00	27.00	97.90	60.20	20.50	25.10	hmmbuild  -o /dev/null HMM SEED	221	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.98	0.70	-11.70	0.70	-4.53	13	97	2012-08-06 14:54:27	2012-08-06 15:54:27	1	2	37	0	58	73	0	209.90	48	85.56	NEW	EVVsQID+LTSDh-aELE..sDDWTTuTlSSTSSS-+...sGss.-Lt+LDFhsuDhLSD..........SW-FCSFL-tSsPsssssssssspsts...................ssapLMNGGl................IPNGPth.TPDSSSEEA.sss........Ksp.....pRTsGTRERVRFSDKVLYHALC..CDD-p-tsppp...ctp..t....p............................sPc..sssuhssutstshsst.....s..++lhRNoSTQTVuDKSTQTlL	........pVVsQIDpLTSDhphE.E..sDs.pTsTlsSoSSSsp.........s.sLt+lchhsss.L.c...........s.thhohLchssPssssst.pss+st.ss..................sshpLhpsGs................IPNGshsphPsSs.-cA.sts....s.Ksp.........p.p.sGsRERVRFs-KV.YHuhC..CDsc..s.tpcEht....ct.-..st....sp...p.........................sh.h.ssshshs...pp.p.shssh....Ptps..sTtspsppTl.cKSTpTsl.................	0	2	7	22
+15106	PF15253	STIL_N		SCL-interrupting locus protein N-terminus	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q15468	Family	\N	27.00	27.00	28.10	27.40	21.90	21.10	hmmbuild  -o /dev/null HMM SEED	410	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.48	0.70	-5.76	17	97	2012-08-06 14:56:12	2012-08-06 15:56:12	1	3	58	0	54	91	0	313.50	46	33.79	NEW	LWsssPhG-hhh.+lthh.RNs+.Lh..lsEKslRLApRHs+Q......sptpshsCFLlGolhVDpDEEGlolslDRFDPGRE........stt.t+hPss.LPGDhllPChl.tpshusspsl.sHsspDhstsFpsLQppls.o+psL-hspLl..slRuplpsp-s.Dtl.hshpWuuVThusshcssPV+slPIIPTALARNL.so.hs.lsplpGshKpGaLTMDpTRKLLL.lLESDPKshoLPLVGlWLsGlsHlpoP......VWusCL+ahaSuulp-R...VhS-sspFlllLaslsa..ppPpFYcC.hspsspt..LpaQLl...ospcslpLa.ppVcsspcp.lphE..LSupspsspts......lFpps.tsh..oh........psssppssss.phssoc...pDSulEDcDlSPR.......P.PoPHPssQpssplhPpVPELSllhDssFhs	.......................................LWsshPhG-hhhLHlsha..RsP+...Lh..lsEKslRLAhRHA+Q.......s.cps.sCFLLGolhlDpDEEu.....lolslDRFDPGRE........sts.thsPss.L.PGDhllPChlphpt.sspphh.scssp-hstshpsLpppls.u+p.l-hsphh..th+sphh.pp...t.h.hphphtuVs.usshchsPl+slPlls.TALARsL.so.h........s.luplpGshKhGaLTMDpTRKLLL.LLESDPKshoLPLVGlWLuG.lh..HlhoPp.............VWAsCLRYhasuulp-R....Vho-sGsFlllLashT+..pp......PpFYcC.hsppsp...hpaQLl...osppslpLa.ppVcssppp.lphE..Lospspshpsp......hFpph.psh..sh........ppsspp.sss.phshpc...psSslEDEDhSPR.......P.PsPHsssQphptl.sphscLulhhs.ph..t..................................................................................................	0	17	20	34
+15107	PF15254	CCDC14		Coiled-coil domain-containing protein 14	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q49A88	Family	This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.	27.00	27.00	28.40	28.30	21.10	25.90	hmmbuild  -o /dev/null HMM SEED	861	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.69	0.70	-13.43	0.70	-6.17	11	77	2012-08-06 15:03:12	2012-08-06 16:03:12	1	3	40	0	44	93	0	449.60	39	86.45	NEW	DSESQs-sVp.GLDGCASLL+DIL+NEDo..GsEhsaScs......Rssu+PLEuKtst.KKKG.cK+hsPshVpKEILSSssKK.IsN-uSsusc+DsSsltQpWSLQDH...Yph..YSPlIYQALCEHVQTQMSLMNshuSKsssNGIPslPCH..ssSsu-oQu.ostSsYGLsTSssVhSPQpPsCP.hVHSEV....QTsu-sQhuSQspssSVsss.slspsshsspPulsC.uLPtsspsAlPshptLshsstlhP.Q...pphsKEsDLLKChQTahuLhpuH......s..hpsDsQsppSsophQsu.hlAosEEcsAcEpIt-ssSEtc-LN.hpltDuchsKslQ........KucNlscTAcKV+hlKYLLGELKALVs-QEDSElpRLlTElEAClSlLPAVuGsTNlQVEIALAhQPLRSENAQL.R.RQLRILNQQLREQEKTcKsoGsh-CNLELhSLQSLNhSLQsQLpESLKSQELLQSKNEELLKVIENQK-ENK+asslFKEK-QTLLENKQQFDIEhT+lKIELEEALsNhKohQFKLEoAEKENQILGITLRQRDAEVsRLRELTRTLQsSMAKLLSDLShDoARsKstssLTKSLLNIY-KQLQcDPsPupTS..IMSYLsKLEss+oh.sHuEsl.shcscEshtPs+.YEssLsScsPp...pusststEEhSAstllsshSKp-SDp-SEohTLlE-csNL.DpTlYIPFARSTSKK+SsLScR.......lSPQPQhsVAssQLssssGl.sSc+Es+hssPsVCSuppp-u...E-uspcLuRsu-hEDcQLLcKIKEsIsKIPsuh.......................-c.c-puspHuPuApppsslplK..GssVsDuSFLNSDLM...SDWSlSSFSTFTSRDEQDFRNGLAALDANIARLQKSL+oGLLcK	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................h..-.s.Lh..+.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	11	13	23
+15108	PF15255	CAP-ZIP_m		WASH complex subunit CAP-Z interacting, central region	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5SRD0	Family	This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.	27.00	27.00	27.60	27.40	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.75	0.71	-4.25	19	184	2012-08-06 15:04:32	2012-08-06 16:04:32	1	4	61	0	91	153	0	131.50	38	14.78	NEW	PhKsKEPS.oRIGKlQANLAINPAALLPGAsPpluGsKslhPthuhssucPstspuscssss.stsuuEtGVSFDtPAQADTLaSANKoRlKhpGKRRPQoRAAR+LAAQ-SsEs..--sssscss..s.htpsssssssppP	................................................sS.shItK.lQ.A.NLAlsPAALLPu..A...u..Pp.sslKssls.hs....P....sSpss...tu.ts.........hsh....s.........tutEsuVSF.D.Ps.p.u...s.TLp.S.s.N.K...sRs+hpuKRRP.oRtuRR.Au.pcSsts.....pshs.scts.....................................................................	0	16	23	45
+15109	PF15256	SPATIAL		SPATIAL	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q53FE4	Family	SPATIAL (stromal protein associated with thymii and lymph node) proteins may be involved in spermatid differentiation [1].	27.00	27.00	48.40	28.50	24.20	26.30	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.65	0.71	-11.56	0.71	-4.24	23	106	2012-08-06 15:09:08	2012-08-06 16:09:08	1	2	40	0	49	103	0	171.60	38	56.60	NEW	FFSRHsPHP+RVsHIpGLNGhPICsVsD-..............shh..p..hP.sth....ssshhthP...hs.lus........PRsspcP.h.........psW+cEL+-huSclslshKcpEhKsKc...................p.s.YSspTGRlhPsuopusoccssp.t.+schptpsh..phssa.DQElhILEhLCQILpTDSLutlQpWLLpAusK..EK-LV.uLlpoAlA	..................................................FhsRHpPHPp+VsHIpsLssh..PlCsVpDc..............s.h......lP.uph....Sts.ht.Pshsls.lus...........PpssppP..........................pthp+EhhchuScsshhhK.cpEhKsKc....................................................sspss+hhss...ssps.uchpop.......pspsptps...ph..h.DQElhlLthLCpILpTDSLstl..WLL.AssK..EK-hs.uLlpstlu...............................	0	11	13	19
+15110	PF15257	DUF4590		Domain of unknown function (DUF4590)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q5RHP9	Family	This family of proteins remains to be characterised and is a domain of unknown function. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. There are two conserved sequence motifs: CCE and PCY. In humans, the gene encoding this protein lies in the position, chromosome 1 open reading frame 173.	27.00	27.00	35.50	34.40	21.60	20.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.57	0.71	-4.28	11	71	2012-08-06 15:24:02	2012-08-06 16:24:02	1	3	46	0	40	56	0	114.30	64	13.59	NEW	VHLuac....DhRDEIKVYQQHCGGENLCVa+G+.LLEsETFpFlS+RHhGFPFSLTFaLNGlQV-RLSSCCEYKH...++GSRLGG..+pGaFGFlsVEGASPCY+C.Il.........uhG.LDKKPpPPh++	...................................VHLupDp...DaRDEIKVYQQHCGGENLCVYKG.....K.LLEp...ETFQ..FISKRH+GFPFSLTFFLNGhQVsRLSSCCEYKH...RKGSRLGG..K+GYFGFVsVEtuSPCY+C.II.........AMG.LDKKsosPp..c.............	0	14	16	22
+15111	PF15258	FAM222A		Protein family of FAM222A	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q5U5X8	Family	This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.	27.00	27.00	93.40	51.40	20.70	24.70	hmmbuild  -o /dev/null HMM SEED	506	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.98	0.70	-13.00	0.70	-5.28	19	161	2012-08-06 15:29:42	2012-08-06 16:29:42	1	3	37	0	87	116	0	305.50	34	95.79	NEW	KWDTTQ+MRS....ApYPTPAELDAYAKKVANNPLTIKIFPNSVKVPQRKHlRRTVNGLDT..SGQRYSPYP.sQuuu+sGLLAIVK.............sP.sKGllK-h-GsR..sRLh..scuhMNPssuPY..susSTLs......H....Pt......tl.h..Qt..............HsQ.............................oLtp...................................................h.H......sQuh.p...............................................................p..shtp.ps.st........t................h..GuRKhPDuD..AP.PNVT..VSTSTIPLSMAAsLpQ...sc.sDLuSIVHQINQaCQARA.GhusTShC.EGQIANPSPISRNLLIsAsoRVSsHs......sss...suC.hlss.-p...u.AslPsust.s.s.hshsthssuY.s..p.....................sWsQH....QLsahQphspsut.........sppsthctstspsFss+s..sYP.chs.huQsaslKs...sh-+ssPSsPV..Ns..ushs......YsNGpYap..PhWssI....LsTPsSDuuGu.QDLshsFpGutsuuss.................................................ssGs+YRhusuu...su.....QsshMQohDYLu.GDFQ..PCF+-QshuhhtKhp.....R.sshs+ss.-sscupshHIQHPGYR	.........................................................s.aPosApLDAaAp+sAppPLoIpIFPssl+VPQ+pplpRTVNGhDT..os.RaSPYs..psss.tGLLAll+..................ss..sKullKs.cGtR..s+h.....s..p...ssY..s..sshs.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................sPh..ss............hssGpYht..s..stl.....sssssss.ss...h..hs................................................t...t...............sp.hpsh-hh..t-hp..s.hp-p.h............c......h........t...t...p...............................................................................	0	3	13	41
+15112	PF15259	GTSE1_N		G-2 and S-phase expressed 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NYZ3	Family	This family is the N-terminus of GTSE1 proteins. GTSE-1 (G2 and S phase-expressed-1) protein is specifically expressed during S and G2 phases of the cell cycle. It is mainly localised to the microtubules and when overexpressed delays the G2 to M transition. the full protein negatively regulates p53 transactivation function, protein levels, and p53-dependent apoptosis.  This domain family is found in eukaryotes, and is approximately 140 amino acids in length. There is a conserved FDFD sequence motif.	27.00	27.00	30.30	29.20	21.20	20.10	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.99	0.71	-4.23	25	105	2012-08-06 15:40:42	2012-08-06 16:40:42	1	1	43	0	46	87	0	128.60	40	24.70	NEW	DlhLLsDEKFDFDLSLS............su...........Susc.....DDEVFhGPVGHKERClAssl.....st..stts..sstssphoWSPLsGEKFsElaKEAHhLALQlEssu+sptspssp.....ptstspssEpFlp-octKlslhppppchcpSPhslKRETasl........p-S	.....DlhhlsDEphDFs.lsLSso...................supE....pDspVhhuPht.hcRslutth.....sp...sptss.sspss+hohuPLosEKh.ElhcEAphLAhQlEpsuhpcpppusp...............h.pt.t.plsh..t.pchp.SP...+RETahlp-..........................	0	5	7	17
+15113	PF15260	FAM219A		Protein family FAM219A	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q5XKK7	Family	This protein family, FAM219A is a domain of unknown function. This protein family has been found in eukaryotes. Proteins in this family are typically between 144 and 191 amino acids in length. There are two conserved sequence motifs: QLL and LDE.	27.00	27.00	30.30	29.00	25.80	23.70	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-11.09	0.71	-3.78	11	124	2012-08-06 15:42:48	2012-08-06 16:42:48	1	2	49	0	67	112	0	120.40	62	71.42	NEW	QK+R-hAR+uL+K+Gh..GsslspQP+pss+....R.oV+aNKGYsuLSQ.os-Es.LVoLDSD.SDsEl-.ppa.SSGYSSA....QVspDLo...+QLLpDGY+LDEIPDDEDLDLIPPKsluossCsC.....s-ssSCslQ	.................................................................................pKpR-LARpu.h+pGsh.GuslspQP+pssh.....R....Vh..NKGYouLsQ.SPDEp.LVuLDoD..SD--h-.S......RY.SSGYSSA.........EQlNQDLs...hQLLpDGY+LDEIP......DDEDLDLI.PPKshsso...shsCp...hssSouCplQ...........	0	11	15	32
+15114	PF15261	DUF4591		Domain of unknown function (DUF4591)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6NUN7	Family	This protein family is a domain of unknown function. It is found in eukaryotes, and is approximately 120 amino acids in length. In humans, the gene encoding this protein lies in the position chromosome 11 open reading frame 63.	27.00	27.00	29.30	27.40	25.80	26.80	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-11.24	0.71	-3.90	15	75	2012-08-06 15:52:54	2012-08-06 16:52:54	1	2	55	0	47	70	0	117.60	37	20.44	NEW	KLGGLGPDh.-uh+s..KhpKLppQKEYA+plKEaNhKsluh..h.ppspss+s-scssls+....+K.ALEYAKoIPKPK...stp...................sQtsKc...tpp..s..stppsslPcIohLEhLpsRHE+EKpsVAAFKsLHIl	................+LGGLGPDh.ps.c...KhpKlhpQKEYAcpl+EhNh+slsh..p...pst+spspsslsc....p+.ALEYAKsIPKP.K...ssp.s...........................................cpssKc....ppp..p...stc-tshsclo.hLEhLpsRHE+EKpsVAuh+hhhh.....................................	0	19	24	29
+15115	PF15262	DUF4592		Domain of unknown function (DUF4592)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6NV74	Family	This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.	27.00	27.00	28.10	28.40	26.80	26.60	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.64	0.71	-3.60	27	118	2012-08-06 16:00:45	2012-08-06 17:00:45	1	2	40	0	57	103	0	116.20	39	13.35	NEW	tpsI+hGps....Ph.hptpc.psussssE-DslPpSP.Ehss.p-sh.ssspppsssh.t.pp....stsupp.p..pssss+sspshps................suuo..slshsusspshupLDNSAA+HKLulKP+pQRsup+	........................................pNlKhG.s....Ps.s.lshK+sp....susso.E-DhlspSP.Ehsh.p-lh.usspppsss.s.sp.p....st.tsc.p..tssss+sSps.t.hu..............suush.slshsssPpu.upLDNSAAKHKLuVKP+pQRsS+...............	0	5	13	25
+15116	PF15263	DUF4593		Domain of unknown function (DUF4593)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6ZR54	Family	This protein family is a putative uncharacterised protein family. Its existence is uncertain and its precise function is unknown. This family of proteins is thought to be found in eukaryotes. Proteins in this family are estimated to be around 155 amino acids in length.	27.00	27.00	279.40	279.10	21.20	20.90	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-10.97	0.71	-4.33	2	2	2012-08-06 16:06:49	2012-08-06 17:06:49	1	1	2	0	2	1	0	155.50	50	89.11	NEW	GpLLushGPSTlPhh.suGuCpPpPLuPGGppPPPPPRAHhuP.EAs.utsPus..LPPTRGl.hKsh.opsuPshpLGGPGLPG+uGPCGPRupPsQs.uGptsssGtGspoPhhTLPCSlstSptlh+GRSHLttsLuslGEARGshAhhsWGQ	GpLLushGPSTlPhh.suGuCpPpPLuPGGppPPPPPRAHhuP.EAs.utsPus..LPPTRGl.hKsh.opsuPshpLGGPGLPG+uGPCGPRupPsQs.uGptsssGtGspoPhhTLPCSlstSptlh+GRSHLttsLuslGEARGshAhhsWGQ	0	1	1	1
+15117	PF15264	TSSC4		Tumour suppressing sub-chromosomal transferable candidate 4	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9Y5U2	Family	This family of proteins is expressed from a gene cluster where in humans the TSSC4 gene is not imprinted [1,2]. This same cluster is associated with the Beckwith-Wiedermann syndrome [3].  This domain family is found in eukaryotes, and is typically between 120 and 147 amino acids in length. There is a conserved YSL sequence motif.	27.00	27.00	28.20	27.30	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.86	0.71	-11.01	0.71	-3.64	50	121	2012-08-06 16:07:49	2012-08-06 17:07:49	1	2	89	0	70	104	0	142.80	25	47.58	NEW	pculFssL-sspc.....................hsssshsp...sssps......................................................puhFK+P.sPssp..............................................hphsplPDYh.tcP-+WTKYSL-D..Vs.p..hS....-poNpAAAluFLtphctp+t............s..sshsp-sssssp...............s+	..........................................................................................pslFspLpsstp.........................sh.p......sp..p.................................................puhFc+P.sPssp.s..........................................sps.slPDYl.tpPc+WT+YSL-D...Vsc..sS..........-poNptAAhuFLpphppppt.................tph.sp.p.........tth....................................................................	0	22	36	54
+15118	PF15265	FAM196	FAM186A;	FAM196 family	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6ZSG2	Family	This protein family is a domain of unknown function.  This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.	27.00	27.00	62.30	52.30	23.50	23.50	hmmbuild  -o /dev/null HMM SEED	514	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.12	0.70	-13.01	0.70	-5.26	27	99	2012-09-25 05:53:12	2012-08-06 17:11:43	1	2	35	0	61	62	0	405.70	40	97.84	NEW	Msp+............ps-scPsh..........h+.uLDssctlK....+RNKu.QVRFKD.spuQNppt.spls.p....st+-upshssK.tA.R+ahsss.sppSlPpspK.....ShulQTSPsL+K+a.oF..cRKK...upsl+phssssshptQsNGhLs-tc.ht...p.ht.st....-uscpst.spshtsps.hhpSstshsht............h.sutpsosuspsP-...pSss.p...sh.ssspssttpsph.......hhstsptcttth.sp-...tsssshsps.t...........ppssplhhPpssspsspssh.s...spscpstsPusspp+pps.s.Ls..shpp.shsttsu.Css.s....pshoscs.ust..shps..............ps...tp.....t..ss........tostthpptsQphls+sE.lsDLpupLQshEphlpSsQEpIKVLLsVIQ-LEKucAhpEGho.YRTGQDhsNCsTCpNoACIIYSVEhDF+QQ..EsKhpsV..L+pLc.shEpsphss.PhppEshsssPcpKoKscp..KKctRhphWaL	.......................................................................................................spp.............p.cscPsh.........h+.uL-ssc.lK....+RsKu.QVRFK-.spupN.pt.tplsst.....ttc-stsh.h+.tA.R+ahsss.hphShPpspK.....shulQTSPsL+Kpa.sF..cRKK.......up.lhphsssps.t.QsNG.L.-.c.h.......t..t....-u..pst.stshhsph.hhpost.hshh.......ss.pssts.hpsP-....u.s.t....h.p.sps..st.psph.......h.shs.tc..ttt..spp....sssshtth.t...........................pthsplhhP..t.ssps.t.s..s...stsc..hsPus.pp+pps...hsuhp..t.s.st..t.Css...s....phho.psspt..s..s...............p.............................ss.............sshth.st...sp.hl...spsE.lsDLpupLQ.hEp.lpSsQEpIKVLLsVIQ-LEKucAhpEGhs.YRTGQDhsNCsTCpNoACIIYS.VEhDF+QQ..Es+hp.l..LppLc..hE...sp..s.P.p...t.s..sssP..cp..pshpcp..KKht+hphWal..........................................	0	4	12	25
+15119	PF15266	DUF4594		Domain of unknown function (DUF4594)	Eberhardt RY, Coggill P, Hetherington K	kh6	Jackhmmer:Q6ZUT6	Family	This protein family is a domain of unknown function. The protein family is found in eukaryotes, and is typically between 170 and 183 amino acids in length.In humans, the gene encoding this protein lies in the position, chromosome 15 open reading frame 52.	27.00	27.00	35.30	35.30	19.50	19.50	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.63	0.71	-4.14	14	111	2012-08-06 16:19:33	2012-08-06 17:19:33	1	2	45	0	55	87	0	163.10	40	33.26	NEW	Ps.pscssRpEGScctsRNWuGssacsV+phs-pp+.c..utRss........stsshDhshuhotpEptEYlRWKpEREQIDpERLARHRsupGpWRRtWDh-Ks-sMh+-ssp.tsptsshstpptt.....cc.p+PPpsPshts.h.pstp.upsp.pstspS+upGpph.......ot+ccRWEtcp-.tpc.p	...........................Ph..scpptpEGSptpsp.shusss.ptlp...-pp+....GtRts..............tssschsh.uh..s.sccptEYhpWKQEREpIDp-RLARHRcupGpWRRtWDh-K...s...csh.hpDs.st.t...tcss....pchss.............ptht.PPhsPshtt...hhspttttspsp.t..ttpS+spu+tt.......os+scRW-h+Et.t...tt................................................................	0	5	8	21
+15121	PF15268	Dapper		Dapper	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5SW24	Family	This is a family of signalling proteins [1-2]. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers [3].	27.00	27.00	27.10	27.10	20.30	24.60	hmmbuild  -o /dev/null HMM SEED	748	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.41	0.70	-13.49	0.70	-5.74	24	169	2012-08-09 10:45:45	2012-08-09 11:45:45	1	4	40	0	81	188	0	446.60	32	88.35	NEW	ERLcAsLAGLpELphLRpRQphhVpusLt.....s..ss.hs.....................hpEphLEtslhsL+cQL.....spLRRpDsGLhspLppLDpQIS-L+LD....VcKsopEtL-oDSRPSSGFYELSDGuSsSLSNSssSVaSEslSS.........hhsusph....csphshuDsRP+S.AD................s............................hGpL-p.h.upst.ppsut.c.p.ss.hspuhcl.sc.lcPKYQs.DLVSKsGp-VY.YPSPLHAVAlQS..PhFhLsh..........Ep.tsssp..ssttst.sss..sssh.p....hsssh.sss..hcuYI.pLLQ+ppptspss+spsu.pus...thhtt.......sss..tpupsss.csptphss.ssGtsshs.....ushpphstcppu.p.pstt...........ssssp.pssshscptspssspphttps.sss...........................psp..ssssptp..pssh................ppspshtP.ppls.ps.........................................s..t.G..thVpupalsu.psp.s+l+p.GsppsKssK.+ppsopKstt.utpt..ts.pp.Rp...............+spthsphsRhP....o.tppspt..pSspppp.hssshh.shlsuR..u....uptpuh..hcutshu.ts..uts++Kp....RRW........................pSosEIShcpt.pp..............s.RRstt.ph..uhhts.hsh..sps.h..u.S-...SEYSAECtSLFHSTls-TSED..EpSsaTTNsFGDSESShS-s-hsspSosoS.o............-uusLlWsphs.t...shp.sssuu.....c.t.sPs.phs+IKAS+sLKKKIhRFpsuSLKlMThV	........................................................................................................................................ptL.....GL...l.pLs.Ql.scLpL-.........tt....h-p-St.SSGFY-.ssususs.t....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................aG-tESS.up.p.s..........................t....hs................................hhs+IKAS+sLKKKIhRFpssuLKlMThV........................................................................................................................................................................	0	5	15	30
+15122	PF15269	zf-C2H2_7		Zinc-finger	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q32MQ0	Domain	this is a family of eukaryotic zinc-fingers.	27.00	27.00	27.00	117.80	26.90	20.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-8.90	0.72	-4.10	2	69	2012-10-03 11:22:52	2012-08-09 12:40:46	1	2	37	0	49	53	0	54.00	86	8.43	NEW	ptRKPKKPHYIPRP.GKPapYpCFQCPFTC..KSHLaNHMKYsLCKNSlSLl.p	..KERKPKKPHYIPRP.GKPapYKCFQCPFTC.EKSHLaNHMKYuLCKNSloLl.p.	0	2	6	19
+15123	PF15270	ACI44		Metallo-carboxypeptidase inhibitor 	Coggill P	pcc	Pfam-B_261362 (release 26.0)	Family	ACI44, a metallo-carboxypeptidase inhibitor, is one member of a battery of selective inhibitors protecting roundworms of the genus Ascaris, common parasites of the human gastrointestinal tract, from host enzymes and the immune system [1].	27.00	27.00	28.10	154.10	26.50	18.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.80	0.72	-9.37	0.72	-3.99	3	3	2012-08-09 11:46:34	2012-08-09 12:46:34	1	1	1	1	0	4	0	64.70	93	86.22	NEW	DQVRKCLSDTDCTNGEKCVQKNKICSTIVEIQRCEKEHFTIPCKSNNDCQVWAHEKICNKGCCWD	DQVRKCLSDTDCTNGEKCVQKNKICSTIVEIQRCEKEHFTIPCKSNNDCQVWAHEKICNKGCCWD	0	0	0	0
+15124	PF15271	BBP1_N		Spindle pole body component BBP1, Mps2-binding protein	Wood V, Coggill P	pcc	Pfam-B_31027 (release 26.0)	Family	This N-terminal domain of BBP1, a spindle pole body component, interacts directly, though transiently, with the polo-box domain of Cdc5p. full length BBP1 localises at the cytoplasmic side of the central plaque periphery of the spindle pole body (SPB) and plays an important role in inserting a duplication plaque into the nuclear envelope and assembling a functional inner plaque [1]. Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge [2].	20.00	20.00	27.20	66.80	19.40	19.00	hmmbuild  -o /dev/null HMM SEED	145	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-11.02	0.71	-3.83	14	27	2012-08-09 11:50:23	2012-08-09 12:50:23	1	2	27	0	16	22	0	154.40	47	40.10	NEW	sus.sGla+WThDALFGs+lSPSpKY.+-.........auQDDTNYphpt............pstps+oR.SsSWss............DssFhc+YDLLssppppshp................................................ptLhsPlclhsp.............................s..pcsTDTFup+............t.pphsstph.hcsPptD....DsllS+LFt+t	.....u.GGhhGLFKWThDALFGoclSPShKY.K-.........aAQDDTNash+hspsp.......s+pssshSRSNSWSGl...........DSoha+KY-LLP-hsEsshs........................................s.cspcclcSLhSPsslsPR............................pPhps-PTDTFupR.........pRpshschussplsFhsPpcD....DPLlSKLFsK...........	1	2	7	13
+15125	PF15272	BBP1_C		Spindle pole body component BBP1, C-terminal	Wood V, Coggill P	pcc	Pfam-B_58229 (release 26.0)	Domain	This C-terminal domain of BBP1, a spindle pole body component, carries coiled-coils that are necessary for the localisation of BBP1 to the spindle pole body (SPB) [1]. Although not a membrane protein itself, BBP1 binds to Mps2 as well as to Spc29 and the half-bridge protein Kar1, thus providing a model for how the SPB core is tethered within the nuclear envelope and to the half-bridge [2]	22.90	22.90	22.90	22.90	22.40	21.60	hmmbuild  -o /dev/null HMM SEED	196	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.85	0.71	-11.38	0.71	-4.75	12	35	2012-08-09 11:51:47	2012-08-09 12:51:47	1	3	34	0	23	31	1	176.50	32	43.31	NEW	c-aos-YlcLLDpLspNs+pLcpLpp-lcp+ppchpppEpoY+pKYhphRtELIpELKQSK+laDNYacLapKYppLKc........hspcs.chppplssL-splVppslpKs+chpphpcclhplcl+tpchp.t+ch-thtYEoRIc-LEppL...pNp.ptpshhup.s.os........s.............p.hpc.N.solDopFlcpls	..........t.capptYhcLhsphshNs+sLccLsc..-lcppccphccpE.....poY+pcYpphRsELlsELK+SKpLa-NYYpLhpKY+sLK+.............................shcpshshpsclu..s.cccLhpcts.KshcIpsLp.pcL...shcl+hppLp.t+p...hpc...sYEScIcDL.hpLp..pss.ptssshsophhSs........s.................c.s.tshssph.cp..............................................	0	4	12	20
+15126	PF15273	NHS		NHS-like	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5SYE7	Family	This family of proteins includes Nance-Horan syndrome protein (NHS) [1].	27.00	27.00	27.20	27.00	26.00	26.90	hmmbuild  -o /dev/null HMM SEED	670	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.46	0.70	-13.51	0.70	-5.89	26	237	2012-08-09 11:54:02	2012-08-09 12:54:02	1	3	40	0	110	185	0	389.90	30	41.26	NEW	stp+SpTRDSuCQTE-lhI...ssPShRRIRAQ+GQ.GIAAphSp.o......GNhSl..LoDsusshF.ssphstssp.hpp.LPRpGuRss.ps.pthts......p........phuphps.-shh..tss.R.....tscspEspspput.......suhhhS.Hus...........Pstolsppucshh.+p.tshGps-hpssSsohsSs.hp.psshs..ttth..K-sHpSSSGsW..sposssppo.pohsssuusshssSShsDSplSLNsss.st-ss..........sps.thpsppssSFsSpstD..scspsutossst.s..tspcph..aps.ssttsps..sphssP....uhoossop.Stss.cpsSsKsDosShYSVDs-GYYT.SMHhDsGL+uspph..s...s.s.thttstpsh.shh-httppp.t...htpc+php+sISL+KsKt.PhPPpRosSLR+hsp............Kpp.p.uph.pEshluohppoLQLsL.tpss.....SSsspSssssh-s.hlhpscSposlussSS.hS...........phhShsssossapDsSulpS-YAD.Whh..Dhpusstc.ts.ossuoAoussshp..pustus.sps............SRuosPsl........PSspsc.KluSPEKhttLsSPSSGYSSQSpTPTuuhPl...shF.pshs.usGtGKhKPKVPERKSSLhSssphSSSSTSLSSsoSc-	...........................................................................................s....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................t..........p.p.ht.shSh+KsKh.P.PP.RosSLhc......................................................................................................................asc.Whh..Dhps.p.s.ts...sssssssus.ssht..ps..pp.p.s............sRss.Pp.........uh.psc..+.hsSPt.+.ttlhSPSSGYSSQSpTPTs.hsh...sh.h..t..s....ssu....ts+.+PhVPERKSSL............................................................	0	4	14	43
+15127	PF15274	MLIP		Muscular LMNA-interacting protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q5VWP3	Family	MLIP is a Muscle-enriched A-type Lamin-interacting Protein, an innovation of amniotes, and is expressed ubiquitously and most abundantly in heart, skeletal, and smooth muscle. MLIP interacts directly and co-localises with lamin A and C in the nuclear envelope. MLIP also co-localises with promyelocytic leukemia (PML) bodies within the nucleus. PML, like MLIP, is only found in amniotes, suggesting that a functional link between the nuclear envelope and PML bodies may exist through MLIP [1].	27.00	27.00	81.60	48.00	21.30	25.90	hmmbuild  -o /dev/null HMM SEED	256	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.66	0.70	-4.89	2	110	2012-08-09 12:06:34	2012-08-09 13:06:34	1	3	32	0	43	83	0	137.00	44	42.14	NEW	ptMQQSDLFKAEYVhIVDSEGE-EAsuRK.-ptPssG.GpuhsRPKSLAlusu.losl.+P+..tsDhpsssps-h.pshAs.QKphQQYKhKSSYKAFAAIPTNTLLLEQKALDEPuKoEploKDsTL-s.lEhh.PAQLRQQTEELCAsIDKVLQ-SLSMHSSDSPSpS.pThLGSDssKhPsTlPRAAGRETKYANLoSPSSThu.SQLTKPGVIRPVPsKS+IlL+KE.EEsYEPNPFSKYLEDsSsLFutQD	.........................................................................................................s.h.t...P........p.t..s.st.h..uhus.ppK+sp.......................................................................................................................................................................................................................................	0	2	4	10
+15128	PF15275	PEHE		PEHE domain	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q68DK7	Family	This domain was first identified in drosophila MSL1 (male-specific lethal 1) [1]. In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3) [2-3].	27.00	27.00	27.00	27.00	26.60	26.70	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.02	0.71	-11.04	0.71	-3.67	27	274	2012-08-09 12:08:56	2012-08-09 13:08:56	1	2	88	5	145	277	2	121.70	32	15.40	NEW	lhsP..sWRsl..slpshsssp...t.t.........hEsLSDpsFspRHpKYE..EpERpRWshhp.pc.pRppp...Rphpcs.............s.sp.ss.shsp..............sps.psschsscsss.shtcsh...lptsp-...................hslPW	........................lhsP..oWRts....slpslcsps.......st-................................hEsLSDssFstRHtKhE..Ep-R..p.....RWsh.pp..pc....p+hpp.....R.hcpp.................t..s.p...spsphoo...hs.................psc.s..ts..h..hs.....s..shtps....h..pp...............h...W...........................................................	0	36	50	92
+15129	PF15276	PP1_bind		Protein phosphatase 1 binding	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q69YH5	Family	This domain contains a protein phosphatase 1 (PP1) binding site [1].	27.00	27.00	28.60	32.40	26.40	20.30	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.19	0.72	-3.95	12	102	2012-08-09 12:15:31	2012-08-09 13:15:31	1	17	45	0	50	96	0	62.80	49	4.09	NEW	tK+KRVoFGtcLSPElFDcsLPsNTPL++GuTPs+ppssts.ssslh.cu......t..c.h.QP..sF-s	.....KRKR.VoFGscLSPElFDEsLPsNTPL++GsTPs++pshsst..o...s...lLcc...........c..sQP...........................	0	10	13	21
+15130	PF15277	Sec3-PIP2_bind		Exocyst complex component SEC3 N-terminal PIP2 binding PH	Wood V, Coggill P	pcc	Jacckhmmer:Q10324	Domain	This is the N-terminal domain of fungal and eukaryotic Sec3 proteins. Sec3 is a component of the exocyst complex that is involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.This N-terminal domain contains a cryptic pleckstrin homology (PH) fold, and all six positively charged lysine and arginine residues in the PH domain predicted to bind the PIP2 head group are conserved. The exocyst complex is essential for many exocytic events, by tethering vesicles at the plasma membrane for fusion. In fission yeast, polarised exocytosis for growth relies on the combined action of the exocyst at cell poles and myosin-driven transport along actin cables [1].	25.30	24.10	25.30	24.10	21.80	21.40	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.09	0.72	-4.12	101	335	2012-08-09 12:23:49	2012-08-09 13:23:49	1	8	228	7	232	344	0	91.70	31	10.66	NEW	pp+Ks.Rhlhlu..lpps.s...lplp...KsKpss........sGs...aplu+oWsLc-Lptl-shsst..................sFslsh.sK.......sYhWpussspE+p.hFlpsLh+lhpca	.......................tcKsphlsls..Vppp...s.........lplp...KsKpss.........sus...aphtcsWtLc-Lptl-uhss................psspFsLph.sK.......sYpWhAsospE+s.tFlpsLh+lhp+Y.............	0	54	101	171
+15131	PF15278	Sec3_C_2		Sec3 exocyst complex subunit	Coggill P	pcc	Jackhmmer:Q10324	Domain	This small Sec3 C-terminal domain family is based around the fission yeast protein, and is rather shorter than the budding yeast/vertebrate domain Sec3_C, family. Pfam:PF09763. In fact it is only this coiled-coil region that they carry in common. The full length fission yeast, UniProtKB:Q10324, protein Sec3 is redundant with Exo70 for viability and for the localisation of other exocyst subunits, suggesting that these components act as exocyst tethers at the plasma membrane. Sec3, Exo70 and Sec5 are transported by the myosin V Myo52 along actin cables. The exocyst holo-complex, including Sec3 and Exo70, is present on exocytic vesicles, which can reach cell poles by either myosin-driven transport or random walk [1].	27.00	27.00	29.40	28.40	25.70	19.80	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-9.81	0.72	-3.85	2	2	2012-10-03 17:31:52	2012-08-09 13:28:37	1	1	2	0	2	3	0	86.00	29	14.06	NEW	hp+L.pLcWsttsshccs.pph..ShstuhhpsVEpLhcpchphpplps.LpDshhGC-ol.STlNLaShpLSssLssVINhEQQ.	...hp+L.pLcWsttsshccs.pph..ShstuhhpsVEpLhcpchphpplps.LpDshhGC-ol.STlNLaShpLSssLssVINhEQQ..	0	1	1	2
+15132	PF15279	SOBP		Sine oculis-binding protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9Y5P3	Family	SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif.  SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis [2]. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein [1,2].	27.00	27.00	28.30	27.80	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	306	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.68	0.70	-12.80	0.70	-4.04	17	146	2012-08-09 12:36:43	2012-08-09 13:36:43	1	5	65	\N	86	127	0	243.80	35	40.11	NEW	sCDWC+HlRHsssYVDFQDGtpQLQFCSsKCLNQYKMpIFh+ETQAHLsh....sPHl+stupstt.........sLITP-LW......L+sC+SpSsus.sssh..ssussPu.............s.ptSP..............pshlosu.sopLhs.p...st...sss...........................................................................................hshsshss...............hppph.tp.psPhhs.ss..............hs..........psshhs.sPttt.hhpPa.p.ss.......s.PPh.h..ssPtshh..sh.s......Ps..............................lPPVTlLVPYPl..lIPLPlPIPIPlPl	............................................................................................................................................................................................................................................................................................................................................................................................................................................................ts.s.hlhs.sp.u.Ps.lP.hhh...E.....pphhQplp.sPhlh...Pspt.........ssssss.shsN.h.s..........ssss...t.....h..s.ss..p..htPa.tss.......sh..s..Psth.h...s.PP..Pst.....suhs.P.s.s........hP.s....P...........hs.h........................VPPsTlL.VPYPV..IVPLPVPlPIPIPl.............................................................................................	0	14	23	43
+15133	PF15280	BORA_N		Protein aurora borealis N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6PGQ7	Family	This family of proteins is required for the activation of the protein kinase Aurora-A [1].	27.00	27.00	28.00	27.30	22.60	26.20	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.82	0.70	-11.56	0.70	-4.98	25	110	2012-08-09 12:38:03	2012-08-09 13:38:03	1	4	81	0	72	106	0	195.70	37	39.28	NEW	husptps.hphTPpssuh..............plhNPFE.ss.hppL+pshh.SPSlF...poss.........spposspFcWSIDQhAhLtPs-I.Dpc.-hpppuhhh......s.........-hE-+hQpAI-pFF.opssIVPSPW......................................s.thh.pp..hhphs..t.oshspph..p..stppssusQ..TsLoLPssh..-LEclLG.caapspcss..ct.............tt......hosSSLRRKLFhsssss.tsspsssssus	.......................................................thphTPpo.sshh.................lhNPFE..ss.hspLHpthlsSPSlF...+o..............osspFcWSIDplAhlpPs-I..Dsc.-hpppshhh......s.t........-lEcKtQcAI-pFF.scssIVPSPW.........................................ts..hpphh..tshp.....sp...oPhspph...t..spppssssQ..ThLSLPssh..sLEplLu..sYFpsc-hs..-ps.......ts.........lSsSSLRRKLFhsssssh..........ss.....................	0	24	30	53
+15134	PF15281	Consortin_C		Consortin C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6PJW8	Family	Consortin is a trans-Golgi network cargo receptor involved in targeting connexins to the plasma membrane [1].	27.00	27.00	33.00	31.90	23.20	21.30	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.76	0.71	-10.54	0.71	-4.58	12	60	2012-08-09 12:38:45	2012-08-09 13:38:45	1	3	36	0	31	52	0	109.40	64	19.29	NEW	ElsPupGLVSILKKRpss.Gpp......lsp.ppcpoKRRVRFpEs-DshDQ.DEsuGsSClLLlLLClsTVhlSlGGTALYCThGDhcSsVCpDFusNhDFYhsplhQslpcL+HWls..hS	...............................ElsPsEGLVSILKKRs-olGcp......sAQhQpKsSKRRVRFQEhDDsLDQ..DEVGGGSCILLlLLCIATVFLSlGGTALYCTFGDMESPVCTDFAcNhDFYYT+LLQGhAELKHWIh.lS.......................	0	2	5	12
+15135	PF15282	BMP2K_C		BMP-2-inducible protein kinase C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q6ZSR9	Family	This family represents the C-terminus of BMP2K and related proteins [1-2].	27.00	27.00	27.00	54.70	26.10	26.10	hmmbuild  -o /dev/null HMM SEED	226	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.76	0.70	-4.17	17	79	2012-08-09 12:40:07	2012-08-09 13:40:07	1	4	35	0	45	64	0	232.80	47	35.62	NEW	tD-hDVFoKAP..........FspKs.............pssstpPcp.sDVFhpuPFp.........................................Kp+ShpcLoshQtpo+p.ssp....u.pphusssss.hs.pPsapo.E+shppptsu.Rsp.SsspFlphos.spcslps..shssups+usshps..............cEshlsPhu.uKPF+PQsLu+aupH.u.pD..................s.shpup.huAa+sssphp.ps.hGuVsh.TsLsspo..........sphsph.DPFuuAPFPSKt	....................--hDVFoKAP..........FspKs.............pshPspPcp.sDlFhpsPFp....................................Kp+SlpcLoutQppo+p.sup.....u.pphGsssssphs.pPsapo.ERAhpppt.stRsp.SospFlphSs.spcslps..sLssupsRGssLps..............cEullsPhu.uKPF+P.sLuhaspH.u.pD..................tpshpsp.huua+sssthp.hsshGuVPh.TpLsspo..........op.spl.DPFGAAPFPSKp..	0	3	5	14
+15136	PF15283	DUF4595		Domain of unknown function (DUF4595) with porin-like fold	Godzik A	adam	JCSG target SP16885A/PDB 4ghb	Domain	Large family of predicted secreted proteins mostly from  CFG group, but also from Burkholderia, Pseudomonas and Streptomyces. Function of these proteins is not known. A 3D structure of a representative of this family from  Bacteroides uniformis was solved by JCSG and deposited to PDB as 4ghb. There is some overlap with RHS-repeat (PF05593) family despite lack of obvious repeats in the structure	23.10	23.10	23.10	23.60	23.00	23.00	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.62	0.71	-11.42	0.71	-4.65	26	98	2012-10-09 19:20:05	2012-08-14 01:41:03	1	6	71	0	9	96	5	188.50	20	52.61	NEW	apYsspG+lsuhsts.pphsst.p....phpss.sshsYssspl...lh......Tcctssss.....sah..LsppGalppCs.....p..phs....u.....phcsasFoYs.....scspLhplscst.........ss...ht.phslsYpsGslsplppphss.tp..............pshhths.hss..sphss.h.s...hshlhlt..-hhs.lsh...hhhAhYuthLGcssppLsh.phhsc.....ss..p..cspsY..oYshDpcGhsos	............................................hst.splhphh...pp..t........hppp.hsh.sassspl......sh.........ss.cttshh..............shh....LsspGasppss.........phss...........p.csapFoYs.....sps.Lsplpcsh.........ss......hp...phslsYps.Gslsplpsp.ps.p................................p.hhphtYss..sphts..hhp...hshlh....hh...chhs.lsh.....h..uhauth..lG....cssppL.h.p.hsp..................ss......pptpa..oaphcppuhss.......................................................................................................	0	4	8	9
+15137	PF15284	PAGK		Phage-encoded virulence factor	Coggill P	pcc	Pfam-B_45688 (release 26)	Family	PAGK represents a new of virulence factors that is translocated into the host cytoplasm via bacterial outer membrane vesicles (OMV). Members are small proteins composed of ¡­70 amino acids. In Salmonella they are secreted independently of the SPI-2 type-III secretion system, T3SS. The OMV functions as a vehicle for transferring virulence determinants to the cytoplasm of the infected host cell. OMVs are released from the cell envelopes of Gram-negative bacteria and comprise a variety of outer membrane and periplasmic constituents, including proteins, phospholipids, lipopolysaccharides, and DNA [1].	22.80	22.80	23.30	22.80	19.80	19.10	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.19	0.72	-4.23	3	81	2012-08-20 15:00:40	2012-08-20 16:00:40	1	1	70	0	3	21	0	65.20	61	93.70	NEW	MK+hNSVFLALVLlLSAoTFSALsMAA-SusHph.psIFPh...WCplWPAGIshPE..h.KhCp	........MKKLKEMAAISLFTLLAAGFSASVMADDQA.....P.....ERVPAAEVKPVGE....HVHWCT.LFDPDGMELPPLP......GMEW.....	0	0	0	2
+15138	PF15285	BH3		Beclin-1 BH3 domain, Bcl-2-interacting	Coggill P	pcc	Manual	Domain	The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.	25.50	25.50	25.80	25.50	23.90	22.90	hmmbuild  -o /dev/null HMM SEED	25	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-6.56	0.72	-6.70	0.72	-4.39	8	70	2012-08-31 13:46:58	2012-08-31 14:46:58	1	3	47	9	34	58	0	25.10	89	6.09	NEW	suush-sLS+RLKVTocLFDIMSGQ	...DGGTMENLSRRLK.......VTGDLFDIMSGQ..	0	5	7	15
+15139	PF15286	Bcl-2_3		Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like	Coggill P	pcc	Jackhmmer:P89884	Family	Pfam:PF02180.  Bcl-2_3 is a small family of eukaryotic proteins associated with autophagy. The family is found in association with Pfam:PF00452,	25.00	25.00	25.00	25.00	24.70	24.40	hmmbuild  -o /dev/null HMM SEED	126	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.70	0.71	-3.68	3	4	2012-10-03 11:38:54	2012-08-31 17:02:54	1	1	4	5	0	9	0	125.20	59	73.14	NEW	TYWATLITAFLKoVSKVEELDCVDSuVLsDVSKIITLTQEFRoHYDSVY+tDYGPALpNWKssLo+LFTSLFlDsINpGRIVGFFDVGRYVCEELLCP.GSWTE-HDLLN-pMTpFFIENNLMNaFo	...............................TYWATLITAFLKoVSKVEELDCVDSuVLsDVSKIITLTQEFRpHYDSVY+...tDYGPALpNWKpsLo+LFTSLFlDsINpGRIVGFFDVGRYVCEElLCP.GSWTE-H-LLN-pMTpFFIENNLMNaFs.............................	0	0	0	0
+15140	PF15287	KRBA1		KRBA1 family repeat	Coggill P	pcc	Jackhmmer:A5PL33	Repeat	KRBA1 is a short repeating motif found in mammalian proteins. It is characterised by a highly conserved sequence of residues, SSPLxxLxxCLK.  The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins.	27.00	0.10	51.90	0.30	17.70	0.00	hmmbuild  -o /dev/null HMM SEED	43	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.97	0.72	-8.11	0.72	-4.60	21	189	2012-09-03 08:46:19	2012-09-03 09:46:19	1	6	22	0	74	223	0	44.00	32	25.27	NEW	Gshup...u...sSs.u.SSPLQGL.sCLK-I.lsG..Pp..pPps.....sss..hsPtP	....................tp...u...sss.u.sSPLpGL.sCLK-Issst...Pp..tsps.........ss..........................	0	6	6	9
+15141	PF15288	zf-CCHC_6		Zinc knuckle	Coggill P	pcc	Jackhmmer:A6NNH2	Domain	This Zinc knuckle is found in FAM90A mammalian proteins.	22.00	22.00	22.00	22.00	21.90	21.90	hmmbuild  -o /dev/null HMM SEED	40	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.38	0.72	-4.28	25	289	2012-10-03 11:39:54	2012-09-03 09:47:41	1	25	154	0	191	274	0	37.10	43	3.39	NEW	RVKCKsCGAFGHpu+SpRCPhKp..WpusLsPQslGs+c..tKE	..+lKCssCGAhGHh+TsKtCPlhp..tp..ss.ss.shu.pp..pE....................	0	65	91	131
+15142	PF15289	RFXA_RFXANK_bdg		Regulatory factor X-associated C-terminal binding domain	Coggill P	pcc	Jackhmmer:O00287	Domain	This C-terminal domain of Regulatory factor X-associated protein binds to RFXANK [1,2], the Ankyrin-repeat regulatory factor X proteins. RFXA is part of the RFX complex, Mutants of either RFXAP or RFXANK protein fail to bind to each other. RFX5 binds only to the RFXANK-RFXAP scaffold and not to either protein alone, and neither the scaffold nor RFX5 alone can bind DNA. The binding of the RFXANK-RFXAP scaffold to RFX5 leads to a conformational change in the latter that exposes the DNA-binding domain of RFX5. The DNA-binding domain of RFX5 anchors the RFX complex to MHC class II X and S promoter boxes [3].	26.10	26.10	26.70	26.70	24.70	25.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.75	0.71	-3.93	7	62	2012-09-03 08:49:35	2012-09-03 09:49:35	1	1	48	1	31	50	0	118.50	71	58.86	NEW	oCTYpGCsETooQsAKQRK.PWMCK+HRNKM.YKDKYK.KKKsDQAhussuh.................hp-....ss-sslSlsKQRsGuhG-RPARPTLLEQVLNpKRLSLLRSPpVlpFLQpQQphLopQshtQppQphpG	.......................................................................oCTYEGCpETToQVA...KQRK.PWMCKKHRNKM..YKDKYK.KKKSDQAlssuGsus........................usss.s+hEESsDshl............SlsKQRTGShG.DRPARPTLLEQVLNQKRL.SLLRSPEVVQFLQKQQQLLNQQVLEQRQQQFs.G................	0	5	8	14
+15143	PF15290	Syntaphilin		Golgi-localised syntaxin-1-binding clamp	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O15079	Family	Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.	25.00	25.00	25.60	25.00	24.60	24.60	hmmbuild  -o /dev/null HMM SEED	305	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.37	0.70	-12.28	0.70	-4.93	19	130	2012-09-03 08:50:22	2012-09-03 09:50:22	1	3	41	0	54	139	0	285.30	55	52.53	NEW	+sssuPsss+cs..YGsoS.s.....SSSNSuShKGSDoSP.phpRssRYpoCGDNHGI+PPsPEQYLTPLQQKEVsIRHL+sKLKESpspLp-..REoEIcELKoQLuRMREDWIEEECHRVEAQLALKEARKEIKQLKQVlETM+sSLs-K.....DKGIQKYFlDINIQN+KLEoLLpSMElAQsGs.hpDEssh-hhC..sSPu+oLs.SsshsKlu-.........uhtht-Q..usEc..huDSGlLssD-h...sspsDlhpp..hhos...sssc...........sssulhpstsh.st..ps..h.th..........ptsh........h.pEpulQTDs......lshSsDlcsll..plhp	.............Rpp.sPlsh+su..YusS.S.s.....SSSN.SGShKGSDsSP.......hhRRS...............s+YhsCu-NHGl+PPsPEQYLTPLQQKEVslRHLKs+LKEopcRLp-..R-oEIs-LKoQLuRMpEDWIEEECHRVEAQLALKEARKEIKQLKQVIETh+ssLh..DK.....DKGlQKYFVDINIQNKKLEoL.LpSMEhApsGs.h+-Ehsh..........-........ss.sSPt+SLshusshs+huD...........shshpppssE-..sADSthlssDsh...sstsDlh-p..hlou...sss-...........phpLhpohshssh..h.t..sh.hh.....................t.psus............h..EpAlQTDh......V.YsPslspllpplh.........................................................................................................................................................	0	2	7	21
+15144	PF15291	Dermcidin		Dermcidin, antibiotic peptide	Coggill P	pcc	Jackhmmer:P81605	Domain	Dermcidin is a family of peptides produced in the sweat to protect against pathogenic Gram-positive bacteria.	22.00	22.00	22.00	23.20	21.90	21.50	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.37	0.72	-10.34	0.72	-3.81	2	11	2012-09-03 08:51:23	2012-09-03 09:51:23	1	1	10	1	2	10	0	94.50	73	82.66	NEW	AYDsEAASAsGSGNPs+EASAAQcENAGEDPtLARQAPKPRKQRSSLLtKuLcstcKulsGLtpLGK-AV-sLEssGKGt..........Vp.sp.sLsSV	...................................AYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAlGGLGpLGKDAVEDLESVGKGA...........VHDVKDlLsSV................	0	2	2	2
+15145	PF15292	Treslin_N		Treslin N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z2Z1	Family	This family represents the N-terminus of treslin, a checkpoint regulator which plays a role in DNA replication preinitiation complex formation [1-2].	27.00	27.00	29.80	29.80	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	803	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.59	0.70	-13.42	0.70	-6.67	11	59	2012-09-03 08:52:17	2012-09-03 09:52:17	1	3	43	0	36	60	0	621.90	46	46.02	NEW	LYWVDTTEhuKLh-SPDHhGYWTlsELLpplGGTlLPsEohstshscstpslhssshcho....spPpLSsW.....hosLPhDSoLNsLLhssscYcAoFPphEGsLFLslctGKc.Q....cossVTLEPLuMpQRphppPVpI.hLKGoVsp......WshPtuuoLGT-SWlLpSs.-p.spssp.....phLFQQLspcLssEcLHLVA-Vsss-uhPPhTGllSPLSsoAslLTVhpsccs.EhQcahLQssssE.sspDssshhsDlVpsVLsplcsu.....-sssss....ssPVPEWsQQEL.....uRTs.PWosAVlE+W.FPhSNlSGASSsLMESFhLLQAsSss.cEEuS+oEuELT+pLSEhYQRKScE-us.susQc-s+KKRG.lPRTPVRQKMpTM....sRSLcMLNVARL...NVKAQKLpPDGuPssu.uEKuhQKssttRosDKlEs+GRsL+SSKsp-FKTEEELLSaI+ENYQKsVusG.-hhLhoCApshloTIKtFLKSpsTK-lEhsC..lsplKspLLKTSKsLRQp.lGpc..hDKEsKVRECQLQVFLRLEMClQCPSlppssD-hEQlVEEVT.-LLRhlsLTEDsuYLucFL.EEILpLYIsSIPcTL.......GsLYpSLGh.IPpKLAsVLPsDFFSDDSMTQEscSPh.shshsSs.sppulssuoEoDQLEELRTRSAKKRRKNALtR...H+SluEsSQNLRQIElPKVuKRss+pE.NS+ss......QQ..PhPpK-sVQEVTKVRRNLFNQEhlSPSKRshK+.hPRS+SVSAVEGLcaK.tphp+s+spth..sa+KLLTKpVuETPlHKQlS+.RLLHRQIKGRSSDPGPDIsVVEESPEKs	.....................haWlDotp..phhtssDHhGa.ph.clLt.hGGsllP..sh...hsp.h..................t.s.......hp.lPh-uslsh.Lh.ps..aptsFP.hpGhLhhsht.sp.......pshsVhLEPlshpQ+.h.psVpl.hL+Gshtp......hshs..sthso-oW..hLpss.tt.ttttp.....t.hFQpLhppLsscplahlupVs...uhsshTullSPlSssshlLTlhpsc.s.thpthhhpsshsp.ssp-s..ss.hs-llsslLs.h.p....psssss....sssVPEWsQQEL.....upst.saosullEpW.FPhSshSGuSSsLMESFhLLpAsstp..p...-..-sScs-sELhptLuEhYQppsp-pss...ttpcppKKRG.lPRTPVRQKMpTM....sRS.LpMLNVARL...NVKAQKhpPDussssu.spKshp+hsttRss-+hcs+u+hh+o.ut.t-F+o.EEELLSa.lpcsYQKsVust..-hhL.ssApshlSslKhFLKScssc-lEhsC.......lspl+.spLLKTSKuLRQphupc...hDc...EsKVRECQLQVaLRLEhChQsPSlpps.--hEplVEEVs.-LLRhls..LTcD...suYLucFL.EEILtlYlsSIP+sL.......GplYpSLGh.lPpc....LAuVLPsDFFSDDShop-shSP....s..Ss.sppusssuscuDpLpELRsRSA+K......R.R.pssLhR...H+SlsEsSQsLRQIElP.......KhoKRs.s+pc.sspss.......................p.s.shKpslQEVTKVRRNL..FN..QEhhSPSKRuh+p.hPRS+SVSAlEGLcp.K......hsp.tp...t.sh++LLT+pVsETPhHKQlSp.RLLp+QhhGR.p.Ssss.-htlVEESP.K.s.......................	0	5	8	17
+15146	PF15293	NUFIP2		Nuclear fragile X mental retardation-interacting protein 2	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z417	Family	\N	27.00	27.00	34.40	34.30	20.90	23.00	hmmbuild  -o /dev/null HMM SEED	599	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-13.23	0.70	-5.79	8	69	2012-09-03 08:53:03	2012-09-03 09:53:03	1	2	37	0	43	47	0	452.40	49	85.05	NEW	ppKKTGaG-lNGsAs-tts.oPKsLsos-sssPs.ShVhNGsQphsDoNlp.KsotKuhThuKsGl+sKshhpKssMDKKN..-KoaESKs+Es.plDKpEslsl.NGVloNNSGYITNGYsGK.GADNDGSGSESGYTTPKKRKAR+NusKGsEsLshhp-KhhQQc.ss..slt.pL-s.Ks..shscttGsRlEGhKPsaKh-sssuG..hupuc.sss-lQRKNSDsKs.GssuKKFEDRsKGKhuossuSKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKsAQss....u...........GEs.s.s.ts.......sRLSQVPMSAhKSVTSAoFSNGPVluGsDGsshss...ustslhss.AAuolss..ssuutssshs.-tussou.......AsEp+KsSLFIY...PSNMQslLPussQ....lshsup.TNQQsLGDIFQNQWGLSFINEPSAGPEsusscssccch.sEVoFQGE.pssshsopusphhPoGsp.hPsFPKAYELDKRTsPQ...uuhlKsu..ossE...uuuhspchph.h-.pKsDsuupGu.hVF.S+sp-l-..ss.AsPossLhuSAK-Q+Yp+GLER+-SWGSFDLRAAVlYHTKEME.IaNLQKQDPKRllTYcE	....................................................................................p+sG.htclNssss-tth.s.+s.sus-hspP..S...NG.spph.cssl....K.o.Ks.o.ststlps+sh.pKpsMDhKN..tKohE.pstEspshDKp-shsl.NGVls.NuGhITNGYhuK.uADND...GSGSESGYT.TPKKRKARpNusKusEslshhp-KhhQpcssss..lt.tL-t.+s..shscptGsRl-usKshaKhEstsuG..sspG+shhu-h.RKsSD.Ks.....GhsuKKhD-Rs.KuKtuosssSKEDSWTLFKPPPVFPVDNSSAKIVPKISYASKVKENLNKssQssos.uss...........GEo..ts.ss...........sRLSQVPMSAhKolTSAsFSNGPVluss-ssh.ss......shhss.AAsolss...hssu.sss...-hshsos..............AhE.hKsoLhlY...P.NMQshL.ustp.....lshPup.TsQpsLGDIFQNQWGLSFINEPSAGPEsshupsscpph.hploh.tc.hst..shsopusphhsoGsp.hssFscAh-L-KRTsPp...hushhpsu...spE...utsh..c.p.h.s-.pKs-spopGu.hsh.Spsh-lc..ss.usPossLhuSsK-ptap+shERp-SWGSFDl+AAlhYHTKEME.lhpLQKQDPp+llhYpE..............................	0	1	6	20
+15147	PF15294	Leu_zip		Leucine zipper	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86TE4	Family	This family includes Leucine zipper transcription factor-like protein 1 (LZTFL1) [1] and Leucine zipper protein 2 (LUZP2) [2].	27.00	27.00	27.10	27.10	26.80	26.20	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.00	0.70	-11.87	0.70	-5.29	18	148	2012-09-03 08:54:27	2012-09-03 09:54:27	1	4	59	0	78	120	0	222.00	42	84.38	NEW	FA+pKRshpLKoVDsCFpDLK-SRLs--TaTsDEVs-hLDGLpsVV+uEVEsELINou+TNVLLLRQLFpQAEKWaLKLQ.sDISELENRELLEplAcFEKp-houus.....p.s.-..ps.K....LpPLsEu.GsutLLs+EIpRLQEEN-KLKsRLKolEppATssL-EKsKLcpsL+-LQh...sp.cs....hhcuQ-ls-LEsplAslKsEhEKshpcposppKsLc-sLhssKHcLL+VQ-Q..LphAEKELEKKFppTuAY+NhKchLopKN-QIK-LR++Lp+	........shpchthpLKpV...Fp-.+pohLh.p.p.TaT.cEl.phLsGLpsslpo.hc.ELhNssaoshLLl+pLhppAcK.h.h+Lp.p-luElEs+pLlEplt..chEKtpho.s.......................Lts.s..Et.......hsK.ItcLQpENcpLKs+Lhohph.ss.th-EppKlpttLp-Lph............s.....hh...+uQplssLEpplAsh......K............s-hpKs.h.Dppp....p.KuLcEslths...hps....lh+sQ.....Lp.hhppp.pp.......hh..p...pshhpph.phhsppp.Q.pt....................................................	0	18	24	40
+15148	PF15295	CCDC50_N		Coiled-coil domain-containing protein 50  N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IVM0	Family	\N	27.00	27.00	27.00	29.30	22.00	24.60	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.15	0.71	-10.92	0.71	-4.23	11	129	2012-09-03 09:22:21	2012-09-03 10:22:21	1	1	71	0	74	106	0	127.30	47	30.86	NEW	MuElpIDQSNLP.tVpEVCpsFAVLEDtuLAHNLQEQE..IEpahuoNlp+N+LVQ+DlpVAKpLQ-EE-....psps.hpppp+-LEcpDsEhAp.IQEcLhppAEctRppEpcDE-IA+pLQEcEhpEp+...R+p+ph	........................LP...tV.pEVC+-FAVLEDtsLAHsLQEQE..............IE.cHhuoNlpRNpLVQcDlpVA..KpLQ.EEDh...+Aps.p...h...p+ch+.....-l..Ep.........pDsElApEIQ..EcL.th..-....AE.c.pR....p..pE.c..cD.EcIA+hLQEcEhppc.++pp...h.....................	0	13	22	50
+15149	PF15296	Codanin-1_C		Codanin-1 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IWY9	Family	This domain is found near to the C-terminus of codanin-1 [1]. 	27.00	27.00	31.90	29.20	21.60	20.10	hmmbuild  -o /dev/null HMM SEED	122	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.96	0.71	-10.59	0.71	-4.25	23	96	2012-09-03 09:23:55	2012-09-03 10:23:55	1	1	75	0	64	95	0	117.00	46	10.95	NEW	ppslDshss..lspplLhssCPaLsEh+slltsshsstsps+....ushh+.pIT.......................Psusp.........t.sppplQt.pLE-AFF+sQPsSlRRoVEFVsERlsSNsVKchpssllhshhppupshlpphh	........p.puLDshsl..VDppLLYsCCPaluEhRpLL.uuhlusosu+...........suGhhR.KIT.............................................Psosp..t.hssps.spspptLQt.pLtpAFFHsQPsSLRRTVEFVAERluSNCVKHIKATLVs-llcpA-shLp-.h...........	0	19	24	43
+15150	PF15297	CKAP2_C		Cytoskeleton-associated protein 2 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IYA6	Family	This family includes the C-terminus of CKAP2 and CKAP2L. CKAP2 is a microtubule associated protein which stabilises microtubules [1].	27.00	27.00	47.50	30.30	26.20	26.20	hmmbuild  -o /dev/null HMM SEED	353	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.45	0.70	-5.63	19	145	2012-09-03 09:24:35	2012-09-03 10:24:35	1	2	41	0	87	116	0	252.30	36	51.18	NEW	Apsssppsp+hhtps+shsppphpsspusss...........pRsstsKEoscE...R.+A+LsEW+suK.G+slKRPPhshh.......t..p.ptpp..EcsstSFWTThsEEDEQ+L....FT-KlNpThuECLpLIs.-GCP+EElLshLsclIpsIP-A+KLsKYWlCLARLEshpuslpclIuIYEcAILuGAp...PIEEhRcsls-ILp.hKsptp.sphupNhpptsssppplp-lp.........pt.shs..cstc.tp-ppcc+ssh.ppspppp-cppc.ssssslp.Tssp-sptuslIKYNVSoTPhLQShKKKhQh-pssu..sh+-LKFLTPVRRSpRlpcKss+LPDMLKDH.PCVSSL-QL.........sElssp.TssFlhR.NsAL	..............................................t.p..t...t.p..ts.h..................pst...Kpsst-....c.+tpLpEWptuK.G+shK.....RPP.phh............tttp..cp.shSFWpoh.....tcE-Ep+h....hopKlNpohoECLpLIp.pGs.tp-lhshLp....pIP.pA.cKhsKaWlChstl...push..pll.slYEcAlhsGAp....PlpEhRcslhsI.Lp...............stphp.pt..t........................................................ts.p...c.tpppp.....p.....p.pppp.th.sss.pht.psppcst..shIKhpls.shPhlpuh..................thp-hKhlTPVRRStRlpct...ss+hP-MLp-H.......sVuSLppL..........-ltt....spsalhR.NtAL...............................	0	10	16	33
+15151	PF15298	AJAP1_PANP_C		AJAP1/PANP C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8IYJ0	Family	This family includes the C-terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration [1]. PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha [2].	27.00	27.00	29.70	33.30	24.80	25.10	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.60	0.71	-4.44	9	85	2012-09-03 09:25:14	2012-09-03 10:25:14	1	2	35	0	49	74	0	163.40	48	56.79	NEW	IsWGPTusD..lE-ss.suhhsssssssst..shTssossuToTstssps.sh.hThp..G...........P.thSThtss.s.sts.....sh.Pphhscsu.GLAVHQIITITVSLIMVlAALITTLVLKNCCuQSupsR+sSHQRKIpQQEESCQNLTDhoPupVsSslDIFTAYN-SLpCSHEClRsslPlYT-Etlp..ossaKouFNGNR	........................IsWGPTssc...Esss.Ps.hsPsh.sl......sh.suspshsTstss.ssth...phpspGlh.s.sP.........................ss.h.PhlhGspu.Glssp.hlTITlSlIhVlsA..TsllhK..C..hspStppRRsStQpth.p...QEESpQsLTDhoP....uulslhsAas-o.pso.-p.cspsssh...sh...pschtssFphNR....................................	0	2	6	17
+15152	PF15299	ALS2CR8		Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N187	Family	This domain is found in amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein [1].	27.00	27.00	27.30	28.50	26.90	25.80	hmmbuild  -o /dev/null HMM SEED	225	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.60	0.70	-4.76	33	110	2012-09-03 09:26:01	2012-09-03 10:26:01	1	15	36	0	86	153	0	199.60	31	36.09	NEW	psshspsssclpWctt...........s.hlshsuhP............Fh........lhspthht.Cpa...Gpc+ctttpc+pppp.........................ptphphptocKhsCPA..plhl+...................clhpFP.................ca+lp...................................................................cspptp+cpshppL+pslhpt............hpsph.caalphPs.ppH.psHshtp.s...............................................shpptlc..............splhpKIccLVppG..lssl.plcc.pL.....ctalpcpha.pspphP.hpsp............pahPohpDl.....cschtpsppphc	..............................................s....ttstp+lhWcsp.............hlPa-GlP...............Fl...........htup..tsh...CQa...G.cRcthphc+hppp...........................pppspp.hKtsCPA..pIhl+...................cV.+FP.................-Y+lsst.................................................................c.h+hppccshphL+pslhs.............hsshh.RaYlpLP..sppsH.phH.htp.sh..............................................sh.pplc..............spltcKIp-LVupG..lpplhtl++.pL.....+pFVcc-LF.cscphPpppNh............paaPTspDI.....pN+htpsphph.p...........................	0	53	55	69
+15153	PF15300	INT_SG_DDX_CT_C		INTS6/SAGE1/DDX26B/CT45 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N7B7	Family	This domain is found at the C-terminus of integrator complex subunit 6 (INTS6), sarcoma antigen 1 (SAGE1), protein DDX26B (DDX26B) and members of the cancer/testis antigen family 45.	27.00	27.00	33.30	32.50	26.50	24.20	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.25	0.72	-8.90	0.72	-4.52	36	206	2012-09-03 09:26:55	2012-09-03 10:26:55	1	3	71	0	105	190	0	64.00	48	9.46	NEW	cchNs-l+pplhKElR+sGRsYcpIFplL.cpVpGsl-l+ppFlchsIKEAsRFKR+sLlpp.LEch	.....pclNs-lKtQlhKElR+.GRcYE.+IFpLL.cpVQGslcs+ptFlc.sIKEAuRFK+RhLIpp.LEc......	0	23	29	55
+15154	PF15301	SLAIN		SLAIN motif-containing family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8ND83	Family	The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1 [1]. They are a family of microtubule plus-end tracking proteins [2].	27.00	27.00	33.20	30.90	26.80	25.20	hmmbuild  -o /dev/null HMM SEED	371	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.57	0.70	-12.75	0.70	-5.29	13	195	2012-09-03 09:27:58	2012-09-03 10:27:58	1	3	43	4	93	159	0	316.00	44	81.31	NEW	hLY......ss.pp.hssspKshSPlpWC.RplL-pPoP-hEsA+.psLph+L-Qh............................................................................h.s...ppsslSPQSSlD.....SELSTSEh--..su.uhsY............KLpDlTDVQIhARhQEES....LRQ-YAoTo..ussSRRSSShShpSh+...............R.ushSDQEhDt.ShE.-c-EphcpLshPpsphhssSP.........hp..s.P+Spo.Soh.................cpsR+Sspu..hs.tt.s.hpp.........................DKLRRShPNLs.Rssuhss.......................spsV+NSpShDSsLpsssuGluRhQSp.s.....l.pps+...usup.PlulRQPhKAsu.husslp..................us...t.hsssu.....shsspss.......s.s.....ossRSuLPRPusssssu.ssPRSKluQPsR..........................phLssPKo...h......usl+DsuW+DGCY	...........................................................................................p.up.psLh.+L-.h..................................................................................................................................................................................p...htssLSsQSSlD.....SELSsS-.....DSIu.sY.........................KLpDl.TDVQIhARhQEES....LRQ-YAuTo...........SR+SSusShpSh+...............+..GThSDQEhDt.SL-.D.--phcphs.Ptsph.psSP..........p..s.P+Spo.uph.................ppsRhS.pup.hs..ppp..ppp.........................-KLRRShPNLu.Rhssh................................oV+sSpS.DSshpssssGls.RhQsp.s...................l..p.h+...............ssu..PlslR.QPl...K...Ahu.husss..s....................st......sssu............tsstss..............h.......hhhR..SuLPRPuhs..h..s...G.sl..PRSKluQPsR..........................p..L.sPKs...h......ushpDtsW+DGCY...........................................	0	17	24	54
+15155	PF15302	P33MONOX		P33 mono-oxygenase	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96A73	Family	This family of proteins contains a flavine-containing mono-oxygenase motif. It may have a role in the regulation of neuronal survival, differentiation and axonal outgrowth [1].	27.00	27.00	77.10	32.50	19.00	18.10	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.23	0.70	-11.82	0.70	-4.80	13	91	2012-09-03 09:29:03	2012-09-03 10:29:03	1	3	39	0	48	87	0	232.10	60	95.71	NEW	uGhLG+MSLPlGhpRRAhSYDDsLEDsAPMTPPPSDhuSplhWKpPVIP-+KYQcLucs..E-scssh......ssls.Suus-shsKlPVVKAKATplIMNSLITKQTQESIQ+FEpQAGL+DAGYTPHKGLosEETKYHRlAEAlH...KL+hQSG-.sKE-+QsoSAQS....TPSoTPpSSPKp............+.RGWFsp.......GSSsuLsGP-hS....ohDuGus-ts+ssu-KWSlFGPRo.lQKSso..G.......GFolQuY+GAQKPSPMELh+AQATphuEDPAsF.KPPKM-IPs.hEuK+..sPRsHNLKPRDMNVLTPTGF	..........hGtMSLPIGhhRRAhSYDDsLEDsAPMTPPPSDMuS.l.WK.PVIPERKYp.cLuc..hE-Gpsshs.....suhs.usuh-s..hppsPVVKAKATplIMsSLIT..KQTQE.SIQ+FEpQAGLpDuGYTPHKGLTsEET+a.hRluEulp...KLphQSGE.s+E-+.suSuQS....TPSoTPpSSP+p............p.R.GWFsp.uuosslsuss.s.....ohD.G....ssp......sts.s-+WShFGPRs.lQKsso..t.......uFuhQuY+GAQKPSPMElh+sQAsRhs-DPAs.h...pPPKM-lPs.hEu++...ss+sHpLKPRDhNVLTPoGF........	0	1	4	14
+15156	PF15303	RNF111_N		E3 ubiquitin-protein ligase Arkadia N-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96B23	Family	This domain is found at the N-terminus of E3 ubiquitin-protein ligase Arkadia [1].	27.00	27.00	30.50	30.40	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	269	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.03	0.70	-4.87	13	116	2012-09-03 09:29:48	2012-09-03 10:29:48	1	3	41	0	57	120	0	236.70	51	37.61	NEW	hKuE.ssDAspptpsLct..ssPcshtsucshsschEshsuKsGs-h.p....-ot....t.susphpo..sLlhch+RcSpputsussp.....................-psSssctpc-SS.ScChpSPSSShHhGDSDTLSSs-Eptsstttuttt.ssts.............upopuuRpp+hsRSEoEoss..hMtt.p.+.........tpp++sssRhphVK......upRoQKQKERIhL.RpKREshAR+KYsLLpsSSoSsp.DLosDSSoSSSpEuE--l.....SGsS+s.ouslP	..............................................................tucshPttsEh.suKsust.sc.Lp.sp.ppptshsus..pp..sLlhch+RcSpput.u.sp.....................ppPos....pssS.scCh.SPSSShHhuDSDTloSsE-pEss.tcots...sut.............utoh.uRpp+hsRoEoEos...hMtt.p.+.........pS.c+.ssRhphVK......upRoQKpKERIhl.RpKREshAR+KYsLL.sSSoSsp.DLos-SSoSSS.-s-E-l.....oups+p.suplP.....	0	2	6	23
+15157	PF15304	AKAP2_C		A-kinase anchor protein 2 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96FF7	Family	This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds [1].	27.00	27.00	28.00	29.40	26.90	26.10	hmmbuild  -o /dev/null HMM SEED	344	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.42	0.70	-12.28	0.70	-4.83	18	145	2012-09-03 09:30:27	2012-09-03 10:30:27	1	7	47	0	79	126	0	242.10	23	39.72	NEW	I.sRPLLopsuhs...ssP.c...+-RuRs.SlalQRDltpETpREcDhRRp.Gh.......ttsusPshhspssp.stLpRthSS......cslLu.ssDupstsPsPEs...++Vs+hsscuYQshLssGss..chss....uhstPst..stttsps.t.spuths.t..hs.sssps.spp.t.....p..t...pst.shl..-..hlp...ht.ph.s....sph....p.hs.chs....ussslRht+sQuSsLLEcElcsVLcRERElpEpRRsshh.sE.......shsPss..s..hc.psup..uSopuuG..hsGohSVSES.hasslphaStLsasspsPs.ts...tpppctthYAGIps.Dtls.EllpuoRVoRHKNuhApRWEuGlas	..........................................................................................................................................................................................................................................................................................................................................................................................................h...h.s.t......tph..........t..t.........ushhlRtp+ppo.shlEcEl+uspEREcELpcQR.phh..sp..........................hhtPs..............c.................Ssotpss..........psshuspps...shtp.....p..ps.h.hh.h.......pt...tt......tpphp.................s.spllcuhRVsR+KsshA.RWEutIhs.....................................................	0	8	11	34
+15158	PF15305	IFT43		Intraflagellar transport protein 43	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96FT9	Family	Intraflagellar transport protein 43 (IFT43) is a subunit of the IFT complex A (IFT-A) machinery of primary cilia [1].	27.00	27.00	27.90	27.70	25.70	25.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.95	0.71	-4.17	34	125	2012-09-03 09:31:47	2012-09-03 10:31:47	1	2	100	0	81	136	0	137.10	37	64.49	NEW	Wu-c.......................u......pcpsppsscphp.tppphpstshp........t..............DIPl..IPDL.--lp.....-EDhhsplAsPPolpss.+VhTh+-LD.sDLhptsuhpsl.........DstlD............LpLLT+.sLsscpplc.EcDpsW-WDpLFTEVouElps-h.stpt	.......................................................................................t.tp..t.......tpthpt...p..........t.t.....................DIPl....IPDL--.lp..........-EchshpVAsPPolpss.RVhoa+-LD..sDLhc.hsAapsl........................DG-lD............LpLLT+.sLsPEcp.lc.EcDssW-WDpLaTEVoSElhs-hp...h........	0	33	39	60
+15159	PF15306	LIN37		LIN37	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96GY3	Family	LIN37 is a component of the DREAM (or LINC) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [1-2].	27.00	27.00	38.90	28.00	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-11.32	0.71	-4.22	48	143	2012-09-03 09:33:57	2012-09-03 10:33:57	1	3	106	0	95	141	1	153.20	28	60.56	NEW	hpps.sps.tt.ppo.............hlhcLa-RuV-Luphppp..ss..........LYs.lCRuW..hcNpsp...hstt.t..............................tsttspplhpLPpP..........tss.h.phPs.hp.ppppttppt..............................hotpsLlppHhpRWKclRp+....Wppp.pppphpR....YppohplLpt	......................................t.pp.....ttt.p.pps..............alh+LFDRSVDLupasps..oP............LYs.lCRAW..h+Ns..Pps.tht.tpst.s.............tp.............psscspslhpL..P.P.........ssssshs.plPsshp.ppptptspt.....p..........................o.ssLltpphpRWK+lRp+Wpct.pppp..RYppshplLp...................	0	31	41	71
+15160	PF15307	SPACA7		Sperm acrosome-associated protein 7	Coggill P	pcc	Jackhmmer:Q96KW9	Family	SPACA7 is a family of eukaryotic proteins expressed in the testes. Proteins in this family are typically between 104 and 195 amino acids in length. There is a conserved DEIL sequence motif. The function is not known.	27.00	27.00	81.90	81.70	19.40	18.20	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.74	0.72	-10.50	0.72	-3.92	8	19	2012-09-03 09:34:46	2012-09-03 10:34:46	1	1	11	0	5	25	0	104.90	59	62.33	NEW	WQt.sphpPpp....pssGSsTEts..FsSppEDluElLDEILVQEIL-......uKTTspEhsSTuTTLpTth....AGh-ENYQtsu..oENYHEhLENlpaSSGTccclSsD-tsAsANLHu	........WQ..sp.cPpp....tssGSsTEIP..FSSKpEDhuELLDEILVQEILDh.....NKTTPoEMPSTASTLST.lH...AGIDENYQAGG..SENYHELLENLQFSsGhEsKlSNDEAsANANLHu.	0	2	2	2
+15161	PF15308	CEP170_C		CEP170 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96L14	Family	This family includes the C-terminus of centrosomal protein of 170 kDa (CEP170) [1].	27.00	27.00	61.90	48.60	20.60	22.80	hmmbuild  -o /dev/null HMM SEED	691	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.28	0.70	-13.26	0.70	-6.27	14	215	2012-09-03 09:35:26	2012-09-03 10:35:26	1	6	39	0	63	196	0	476.50	42	45.21	NEW	suchshphp.ss.s.p.sshusts.p...u.FVRQESFTKEpuSusls.sKLPHISSHPh..........LpDLpss+usph-h.opDT+LlLKETEosLAALEAKLhsppspt-st..........sssst..-DSLSG-SDVDTASTlSLlSGKstsssos...pt..shuuhQKEKSSossusQD....ss.sSARERLoEKp+p..ssts.tpsEss+R.hph+RupGspGSLDhTDD-+uSuhsa.PsoDhsoSDpEp.....uuRstsR+KP.st.....ssK-Epu+sotssp+s..........QQsLTRSNSLSTPRPTRAS+LRRARLG-ASDsEsADs-+us.u...ss.sussuKssspsKKLSRLDILAMPRK.RAGSFTsPSDoEus.s.RouFSGR..SlEthhsuRKs.osu-u...+suu++sAsus......s+QPh..oRsRouSs+YoSsosp....RRQpGSDYoSTSE-EaGSs+sSPK.H.....pRSHsSTAhQTsRspss.utsp.h...ss.u.....sppp---.pcEs-sY..hhs.TuchA.EI.ARL.SQsLsKDlAILAREIHDVAGDGDShoSuGsu.Sool..SolP..sTPASTISsREE..............LVQ+IPEASLNaQKVPPGuhu........sc.shDQs..hsDsp-cshup+pRshsR-E...............VlhDNLMLNPVSQLSpsIRENTEpLApKMKILFQNptRsWEElEAKIsoENEVPILKTSNKEISSILKELRRVQKQLEVINAIlDPsGsLDlhsuN+usu	..........................................................tp.................t..s........t.hlRQtSFTh-.soss...s.thlP+Isp...............tphtttptth....s.DTthlLK-oEsshAhLEA+l.pp..................tss....psSlSs-SDVDTuSTlS.hsucst.ps............s..+-pss.sss.ps.......sss+-p.pc+t+.....................puth..sShDhss-ppsss......s-.hsss.p.......s...spp....................p.pts+..s..................ts.s+psoLstPRPTRsShLRRARLG-sSDs-.s-s-+hs.t....t.....sst..s.tt+tlSRlDhLA.PR+.RhGShss.SDsEss.s......pss.SsR..ss..E.h.t.th.....sts....+.ss+httssh........s+.s...s+s+s.ssthssss...............................................sshp..p.t..s................t.pcc...cE.-.Y..hhs.Tsc.t.EI...A............Rl.......SQ....DlAllAREIpDVAG-hDS.sS..su.su..uso....tshs.ssPu..osl..ss+-E........................LVp+l.-tS.......LNapKlPPhshs...........st.s.c.p.....s-..c.....+pRsh..sR-E...............shhDsLhLssV.QhSptIRpsh-phAtKh+ILFpsptRsW--lEuKlpuEsElPllKTSshEISSILpEL+RVpKQLpsINshlDPsGsL-h.h.s...h.....................	0	4	11	30
+15162	PF15309	ALMS_motif		ALMS motif	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96L16	Family	This domain is found at the C-terminus of Alstrom syndrome protein 1 (ALMS1), KIAA1731 and C10orf90 [1-2].	27.00	27.00	27.00	27.00	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.06	0.71	-10.76	0.71	-4.33	17	152	2012-09-03 09:36:21	2012-09-03 10:36:21	1	5	71	0	88	160	0	123.80	34	9.40	NEW	shl+hoLQEALph+RPDFIS+StcRlKRL..cLlscER+hQphhppERctLFs.s....cp.tt....s..hshp...hth.+..pRslsKKEMlpRS+RhY......cpLPEVp+++EEE+RcscYpo.RL+AQLYKK....KlpN...plhG.++s.hp	...........................................phoLQEuLph++PpFluRSppR...hK+L...chhsp..p.R+hp.phhpt...cpp..thhs....................tt.......h.h.shp.s.hhhs+.....pRhloc+EMptRo+RlY......ppLPEVpp++.EEp+..+ctt.......hpoNRL+AplF+K....plhsplht+p....s.....................	0	24	31	49
+15163	PF15310	VAD1-2		Vitamin A-deficiency (VAD) rat model signalling	Coggill P	pcc	Jackhmmer:Q96LK8	Family	VAD1-2 is a family of proteins found in eukaryotes. The family is expressed in testes and is involved in signalling during spermatogenesis.	27.00	27.00	165.10	48.60	22.30	21.90	hmmbuild  -o /dev/null HMM SEED	245	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-11.65	0.70	-4.71	8	28	2012-09-03 09:37:07	2012-09-03 10:37:07	1	3	21	0	13	30	0	218.50	53	65.13	NEW	EE-QV.sssHRSIRVQTSKHLFWADKLIQASEHSLQ+thshQ.t+posscTsup.spp.l.pcshsSc.cQLQsPSspPs.PuTsS.Q..P.oPp..SS..sLoPAIGLAELlNFASSLAlASSSKhDLPNLEHMIKuPPQ...KAppPST-Pss...p.As-pp-tcpp.....sch.sEKP.LEss..EspKuaKQEDKNls+PYLDFSKPGhKRATIEGEVKLLQsPAhSPp.QGApKDSVPGTKKGoPLLLKIHFKLSSPoSPE	..........EEpps..Sus++SIpsQTSKHLFWAsKLIQASEHSLQ+slshQ.pptSsspshpp.hppslspsshsSc.cQlQ.PsupsuPPsTuSQt..PSPh..SS..sLsPsIGLsELIsFASSLAhASSS+hDLPsLEHMhKAPPQ...cAhEPSTEPhh....p.ss-cp-scpp.........sEt.sEKP.tEAt...ts.KuWsQEDKNhspsYhDFSKPGlKRATIcGplpLLQsPApSP.LQGuccDSVP.GpcKtsPLLlKIHFKLSuPo.PE............	0	1	1	1
+15164	PF15311	HYLS1_C		Hydrolethalus syndrome protein 1 C-terminus	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96M11	Family	\N	27.00	27.00	27.10	27.10	26.60	25.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.22	0.72	-3.75	20	80	2012-09-03 09:37:52	2012-09-03 10:37:52	1	2	70	0	59	82	0	79.30	40	26.71	NEW	IRPthpt.pppt....tKsDPVs+YapY+cpWcph+sP.GEcpRpsLRWplREpMhpps....s..+s.+hhl.PNsYlVPTpKKRpALRWplRspLA	.............IhPhhsp.pppp.....tKsD.Vu+YapY+c-Wcph..+..hP.GEccRppLRWsVREpMLp+s....s..hs.+hhl.PssYlVPotKKRpslcWtlR..hs...................	0	20	22	41
+15165	PF15312	JSRP		Junctional sarcoplasmic reticulum protein	Coggill P	pcc	Jackhmmer:Q96MG2	Family	JSRP, junctional sarcoplasmic reticulum protein 1, or junctional-face membrane protein of 45 kDa homologue, is a family of eukaryotic proteins. The family is to the junctional face membrane of the skeletal muscle sarcoplasmic reticulum (SR); it colocalises with its Ca2+-release channel (the ryanodine receptor), and interacts with calsequestrin and the skeletal-muscle dihydro-pyridine receptor Cav1. It is key for the functional expression of voltage-dependent Ca2+ channels.	25.00	25.00	30.60	29.70	23.40	18.60	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.47	0.72	-9.11	0.72	-4.01	17	32	2012-09-03 09:38:57	2012-09-03 10:38:57	1	1	26	0	19	27	0	67.50	50	25.24	NEW	s-ELPWG-lTLNKCLlLASlVALLuSuFQlh+......DslsGptssst..sPt.Wl..Pou.ss+c..st.sPtP......c	..p-ELPWGDloLNKCLVLASLVALLGSAFQLC+......DAVsG-ssh.t..sPtsWV.PPSS.sP+c.ss.uPhPc.........................................................	0	1	2	7
+15166	PF15313	HEXIM		Hexamethylene bis-acetamide-inducible protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96MH2	Family	HEXIM is a transcriptional regulator that functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA it sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.	29.00	29.00	29.70	41.00	28.90	28.50	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.59	0.71	-3.95	25	120	2012-09-03 09:39:46	2012-09-03 10:39:46	1	2	80	4	79	116	0	132.50	41	43.16	NEW	WK.PY.K.LoWc.............E+pph-Epps..pRAsRl............hu+GpPlAPYNTTQFLM-DH-tpE................................scLssssthpcttss.........................sspst.hsup-Dp....................................................FLp+-FS-sYEph+.sEpLpsMSKpELlpEYLcLE+chuclc	.............................................W+PYhc.LoWp...........................E+pph-E+po.....pRAoRlRt.....pMFA+GpPVAPYNTTQFLM-DH-.cE........................Pc...Lcssph.p+ss..sps.................................................ssssp.tspscsct-.........................FLp+DFSEsYE+hH.sEpLQsMSKQELlpEYL-LE+phSph......................	0	23	29	50
+15167	PF15314	PRAP		Proline-rich acidic protein 1, pregnancy-specific uterine	Coggill P	pcc	Jackhmmer:Q96NZ9	Family	PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homologue. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression [1].	27.00	27.00	54.30	30.00	24.00	21.50	hmmbuild  -o /dev/null HMM SEED	45	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.04	0.72	-8.76	0.72	-3.67	15	33	2012-09-03 09:44:09	2012-09-03 10:44:09	1	2	22	0	16	31	0	44.80	55	28.18	NEW	PE.D+DsLYH..PtspE...sQtEscPhsp...sl.s+pVLp..GPEED+DHIYH	..PEPD+DuLYH..P.s-E...sQsE-pPhhh...shss+QVLp..GPEEDpDHIYH	0	1	3	5
+15168	PF15315	FRG2		Facioscapulohumeral muscular dystrophy candidate 2	Coggill P	pcc	Jackhmmer:Q96QU4	Family	This family of proteins is found in eukaryotes. The family is localised close to the D4Z4 repeats on chromosome 4 and 10 that are associated with the autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). FRG2 are transcriptionally upregulated in FSHD myoblast cultures suggesting involvement in the pathogenesis of FSHD [1].	27.00	27.00	29.00	28.50	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	181	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.48	0.71	-11.39	0.71	-4.31	8	40	2012-09-03 09:44:56	2012-09-03 10:44:56	1	1	15	0	18	49	0	172.50	58	68.15	NEW	GSEPppcE.-sSpEo-hptps.SsusoEsESuophEusRKRKhSS+DSopsssGus...st..EsSsohcpK+.Rsss.us+ssEspcsusu+pcspu..tsG+pcRpRsRs.sscPPPlRKSLVToLRuhSEAIYpDlsQhpAQQttSPLT.EQLstLuQLpGPLsAslQTlYoMAsQAAaAFPAEGWL	..............................GSEPsPNc.ENScEoKL+usN.SoAsSEsESSShpENsRKRKISS.+DSspDpAGNC......Pc.cEsSloLpKKu.RuST.uVHsSEIQETs-uH+RGpSRApoG+u+RHRSRuhuspsPsLRKSLVTSVRuhSEAlYQDLAQVhAQQh+SPLTpEQLohLoQLRGPLCAtVQThYoMAoQAAasFPAEuWL.....	0	3	3	3
+15169	PF15316	MDFI		MyoD family inhibitor	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q99750	Family	Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors [1]. They affect axin-mediated regulation of the Wnt and JNK signaling pathways [2], and regulate expression from viral promoters [3].	27.00	27.00	50.20	49.80	25.30	24.90	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-11.44	0.71	-12.10	0.71	-4.27	9	115	2012-09-03 09:45:47	2012-09-03 10:45:47	1	1	42	0	61	106	0	162.80	51	76.62	NEW	QPps..........lPh.ssustcs.ptEhGphps.......sGs.....Gsh....ss..............p+hp+KlposhSlsSsuu+KSKsuo.....sppsuphP..tp...DCCVHCILACLFCEFLTLCNlVLspAoCGh.CoSEs....CCCCC.GsshGsDC....sCPCDMDCGIhDACCESSDCLEICMECCGICFPS	......................................................................................p..thps.....lsNGs..Gh.p..Gstphuus........h.u..Assu..pKhH.RKlQ.op.SlsSpsSKKSKssu.....pppsup.P...tE..DCCVHCILuCLFCE...FLTLCNIV...LspAoCG.......CoSEs.....CC......CCC.......Gst......s...sDC....shPCDhDCGIhDACCESuDCLEICMECCGlCFsS.....	0	2	9	21
+15170	PF15317	Lbh		Cardiac transcription factor regulator, Developmental protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BQE6	Family	The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart [1].  More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions [2]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.	27.00	27.00	28.10	33.50	26.60	17.70	hmmbuild -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.47	0.72	-3.73	18	80	2012-09-03 09:46:51	2012-09-03 10:46:51	1	2	40	0	42	78	0	86.90	56	67.14	NEW	MTEV.hso..ssh--hsls.......PccspLohQIFPDsu-h....-cssK......LKcRLPSIVVEPTE.uEVESGELRWPPE-hLlp.p-pc-ptt-pthpsppp	........................MTEVhMso..ssM--huLs.......PcKDtLSaQIFPDPSDF....-RsCK................................LKDRLPSIVVEPTE.GEVESGELRWPPEEFLlpED-p-pspEsttpsp..................	0	2	8	19
+15171	PF15318	Bclt		Putative Bcl-2 like protein of testis	Coggill P	pcc	Jackhmmer:Q9BQM9	Family	This family of proteins is found in eukaryotes. The family may represent a set of Bcl-2-like proteins involved in apoptosis, see UniProt:Q9BQM9.	25.00	25.00	69.60	40.30	19.90	19.40	hmmbuild  -o /dev/null HMM SEED	180	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-11.37	0.71	-4.28	6	22	2012-09-03 09:50:31	2012-09-03 10:50:31	1	3	17	0	10	20	0	140.00	60	88.05	NEW	MGNsSSHKRTKAPKQA+KE+PPDMDKA+t.+QFFSHLKpK........KPus..................uhhsKIVLLFPLDKRQQLAEA.......ut.s......-cssG.....As.s....uhPA.APMLRGAGDus-RR........c.......ch.plhlLL...hlt.-uhhttc.........G.......GuKuAQsWQcLas+LLocuEA-sEuss.AEEQPRKRR+CPR	.....MGN.SSHKRTKAPKQA+KERPsDMDKAha.KpFhsHLpRK.............KPus..........................+IVLlhPLDKRQ.LApA........sp..-.ssG.....As.h....u.PA..APhLRGAG-Gs-Rc..........ch..lhlLl...h...-sh..t-..........G.......GA+us.sW..Lhs+hho.tcsstEuts.tcpQPRKpp+s.R...........	0	1	1	2
+15172	PF15319	RHINO		RAD9, RAD1, HUS1-interacting nuclear orphan protein	Coggill P	pcc	Jackhmmer:Q9BSD3	Family	RHINO, or RAD9, RAD1, HUS1-interacting nuclear orphan, is a family of eukaryotic proteins [1]. Under genotoxic stresses such as ionizing radiation during the S phase, RHINO plays a role in DNA damage response signalling. It is recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent (ataxia telangiectasia and Rad3-related) manner. It is required for the progression of the G1 to S phase transition of breast cancer cells, and it is known to play a role in the stimulation of CHEK1 phosphorylation. It interacts with RAD9A, RAD18, TOPBP1 and UBE2N [2].	25.00	25.00	37.30	32.90	20.40	20.10	hmmbuild  -o /dev/null HMM SEED	236	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.49	0.70	-11.76	0.70	-4.55	18	48	2012-09-03 09:51:53	2012-09-03 10:51:53	1	2	35	0	26	42	0	219.60	49	98.14	NEW	MPP+KKRpppspKAQLLF+ppPLEGPKHchuSPQhsh.THT..RQVPoKPID+sTlTSWVSPQFDsTsEoaFPuppK....H.R.......c........pA+pSSRKSsos..KFPpLoFEospoS...S.S.-.sL..uls..hs+......-s.PsQscKDlopRPLVPhLSPQSCGElSs+.....sLpohPhVFlPPDIQTPEsS......sl+p....s......slPs-p+csuLsu.CshHssoPpSP-PGPVLVcDTPEEKYGlKVTWRRRcHLhsYLRERGKLS+SQFLV	.......................MPP..+..KKR...pp.opKApLLF+ppPLEGPKHphuSsQhsh..THT+QVPSKPIDps...TlTSWVSPQFDssupoh.FPstpK....Hp..............s...............pA++uSR+osos..KFPcLoFEospsS...S.S.-.sL..uhs....hh+...............cs.Psps...cKslsp..RPLlPhhSPQSs.uphSsp.....t.pshshVhhPPDlQTPE.S.......s+p............p..ls.spppsph.s.s..tssoPt.ss-PusVLVcDTPEccYGlKVTWRRRpHLhsYL+-RGKLspuQhLV........................................	0	4	5	10
+15173	PF15320	RAM		mRNA cap methylation, RNMT-activating mini protein	Coggill P	pcc	Jackhmmer:Q9BTL3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 102 and 154 amino acids in length. There is a single completely conserved residue D that may be functionally important.  RAM is a family of eukaryotic proteins that are an obligate component of the mammalian cap methyltransferase, RNMT (RNA guanine-7 methyltransferase). RAM consists of an N-terminal RNMT-activating domain and a C-terminal RNA-binding domain. Either RAM or RNMT independently have rather weak binding affinity for RNA, but together their RNA affinity is significantly increased. RAM is necessary for efficient cap methylation, maintaining mRNA expression levels, for mRNA translation and for cell viability.	25.00	25.00	25.90	28.30	22.30	22.30	hmmbuild  -o /dev/null HMM SEED	81	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.38	0.72	-10.06	0.72	-3.72	24	82	2012-09-03 09:53:27	2012-09-03 10:53:27	1	2	67	0	60	71	0	82.00	43	64.28	NEW	pchE-hFssRFT--DpEapcahp..+PscsPPlV-sW..p.....u...p....suGsp.........+sp.ssphp.s..pcph....pGpstpt...shpstsR..pp.pa.ps.R...saup	...saEEhFAsRFT--DcEYQEYlc..+Ps-sPPIVEpW...p.....u..R....uGGsp.........................Rsc.sNphp.s..sRpa....cGcss+t...GWsscs+..tp.pa.ps.R..sht....................................................	0	10	14	33
+15174	PF15321	ATAD4		ATPase family AAA domain containing 4	Coggill P	pcc	Jackhmmer:Q9BU68	Family	ATAD4 is a family of proteins is found in eukaryotes. The family is also known as PRR15L, or proline-rich 15-like. ATAD4 is expressed almost exclusively in post-mitotic cells both during foetal development and in adult tissues, such as the intestinal epithelium and the testis. Its expression in mouse and human gastrointestinal tumours is linked, directly or indirectly, to the disruption of the Wnt signaling pathway.	25.00	25.00	25.00	60.40	24.70	24.80	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.42	0.72	-10.29	0.72	-2.98	28	78	2012-09-03 09:54:15	2012-09-03 10:54:15	1	2	41	0	44	68	0	89.60	47	75.69	NEW	WWK.LThhRKKps....ps.+VhhpsP.................................sp.....us.........ss..sspp.......s......s.....p....sst.stcs........phssRL....-Kls.ccp...sppRplKVS+SGRFKEK+KVRATLs..p	...................WWK.LTh.RKKcu....ps+Vhh-hP.................................sph....us............ss..uusc.......t......s...ps......sst.sssu.........shssRL....EKls-cp...optRplKVS+SGRFKEK+KVRATLs-p.	0	4	8	19
+15175	PF15322	PMSI1		Protein missing in infertile sperm 1, putative	Coggill P	pcc	Jackhmmer:Q9BUN1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 249 and 341 amino acids in length.	25.00	25.00	26.10	26.10	24.70	24.10	hmmbuild  -o /dev/null HMM SEED	311	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.20	0.70	-5.34	11	35	2012-09-03 09:55:01	2012-09-03 10:55:01	1	2	23	0	14	27	0	272.00	60	89.90	NEW	AQG.Tpo.Tu....hQRVSFRFG.....GP.ho..RoY+oTu..RT...shPR+hR..VThEDEsDssAsADRLAGPAAAELLAoTVuTGhu+sp...ss.s....-EDGSLEEGVVIsARKsso....shct.sssspT.stusoo..RFhANoQEPEIRLTosl.suoh+sTt..-.lsS-sTLopWSTAGSTPsRWPsPSPTAMPP.PEDLRLVLMPWGPWHCHCKSGTMSRTRuGKLpGLSGRLRVGALSQLRTEHRPCTYpQCPCNRc+EECPLDouLCsDosCoopsosp...ohsshPslahRhpPs.h....s...SP..SPALAFWKRVRhGLEDIWNSLSSVFTEMQPl	..........AQG.TpTsTt....MQRVShRFG.....GP.hs..RSYRoTu..Ro...slPRKhR..lhLEDENDAhAsADRLAGPAAAELLAuTVuTGhSRSS...s..s....EEDGShEEGVVIsAtKsso.........stchsSssssT.sGuSST..RFhANoQEPEIRLTosLPposh+sTp..D..sS-sTLopWSTsGSTPsRWPsPSsTAMPs.PEDLRLVLMPWGPWHCHCKSGTMSRoRuGKLpGLSGRLRVGALSQLRTEH+PCTYppCPCNRh+EECPLDouLCsDosCuopsTTp...ossshsslHhRppP..h...Pss...SPsPALAFWKpVRIGLEDIWNSLSSVFTEMQPl...............	0	1	1	1
+15176	PF15323	Ashwin		Developmental protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BVC5	Family	This family of proteins are found in eukaryotes. These proteins have an important role to play in developmental biology, particularly embryogenesis. It plays an important role in cell survival and axial pattern [1]. It is also thought to be a crucial subunit in the tRNA splicing ligase complex[2]. Proteins in this family are typically between 141 and 232 amino acids in length. There are two conserved sequence motifs: HPE and PQR.	27.00	27.00	32.40	32.40	24.90	24.60	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.46	0.70	-4.34	17	75	2012-09-03 09:55:43	2012-09-03 10:55:43	1	3	67	0	50	70	0	183.50	38	84.61	NEW	ss.hLLHPEL..LSc-FLlLhLp.p+sIhscs....p.sKDpLT-LYlpHslPLPQRcLPcsRWGKhhEKpRt.p.th......tspp............ppssss-s.RKRPLI.........VFDGsSoso.slKl+Ks-su....ss.DRLKPPP.s..hossl+KLSssospsSsss..ss................p.s........spsshts.ps.P.o.........hstssssKL.....................KRsuspp.-sssss-hKssEsK+KIQHV..TWP	.........s.-hLLHPEL..LSpEFLLhhLc.p+....sIsVEs....+hsKDsLsDLYlQHAlPLPQR-LPcsR..WGKhhEKcRp.pp.ch......pspp..........................ppss..ss-s....RKRPhI............VFDG.sSooo...olKl++s-su......ss.DRLKPPP.t.......hossh++lptsss.psus.....s....................p..........tpt.....p....p......ht.sssspL.....................KRssspp.t.p..tphpsspsK+KIp+l..TWP..............................................................................................................................................................	0	12	15	32
+15177	PF15324	TALPID3		Hedgehog signalling target	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BVV6	Family	TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.	27.00	27.00	34.00	33.50	24.10	25.60	hmmbuild  -o /dev/null HMM SEED	1252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.39	0.70	-14.02	0.70	-7.21	10	106	2012-09-03 09:56:21	2012-09-03 10:56:21	1	3	35	0	35	97	0	709.20	48	82.78	NEW	sDIFISQYosGQKDALRAVLKQKAQShPVFKEVKVQLLEDAusEKcsl.uQEsRhSPuGIDSATTVAAATAAAIATAAPLIKVQSDLEAKVNSVoELLsKLQETDKQLQRVTEQQTsl.QsKpEKlHCHDH....EKQMNsFMEQHIRHLEKLQQQQIDIQTHFISAAL+ouS...aQPsslPsSRsVEKaslKs-psslGuushSS+ssFss+p..As...................h+psEDhuFDcQKSPLETPAPRRFAPVPVSRDscISKRENPhEEKENh-hssp+GssRLLEQILNspDo.oRKSESS-.tTSLopSKhGWNPE...+ps........pFPSsEELGTAcVTVQKu-DlLpDLGQK+KEoculLQ...KpS.shlcLuDhPQsss.+.............LQoTpsTRSlLKDAEKILRGVQNNKKVLEENLEAIIRAKDGAAMYSFINALoTNREhoEKIRIRKTVDEWIKsISAEIQDELuRKDYEQKRFDQKspRsK+ApsM.......SK-IKsNTQ-Ks...lN+ssh.tK..pKQlE..-phcs..lpshs.Sshp.+cR+-GhLKussllQDEDYhhQlYGKPVYQGHRSTLKKGPYLRFNSPSPKSKPQRPKVIEpVKGTKVKShRTQTDhaATKPlKhDSKhpHSlshLP+u-.QQYLFSPSREMPThSGTLEGHLIPMAILLGQTQSNSDShPPAGVlVsKPHPVTVTTSIPPSSpKscTGVKKPNIAVlEMKSEKKDPPQLTVQVLPNVDIDSISNGSu-sS.s.ssSPcEAS.sPlpsWIQsPEhhKsDEEElKFPGoNFDEVIDVIQ-EEKsDE.IPEaSEPlLEFNRSlKVVSTKYNGPPFPPVASssQPTsDILDKVIERKETLENSLIQWVEQEIMSRIISGhaPlQ.pQsssslSVSsSEsSEPlTSDIVEusuGGuLQLFVDAGVPVNSDMIsHFVNEALAETIAlMLGDREu++ssPsAssVPGsloosET.L.ARlsTPVATPQPTPPpS....PsSssKEhVLVKTP-SSPCsS-HDsshPlKElhAEcGsD.hPAlTLVsTPsVTPsoTPPPA.AuhTPThSEhSI-KLKhsSPELPKPWuDuDLPL-EENPNslpEEshaPRAlVMSVAKDEEPES.chPs.PusPc.PlPhpPhPsus+APSsspsPSS-SST.ESoLShT.sTETETLDRPISEGEILFSsGQ+LAs+.luDuG.LaLsNLNDSLSSTLpDAhEMEDDPPSEGQV.IR+PHKchHpDslLSLLAKQNQcslsSQQulYHSEDLENSVGELSEGQRPpLsAAAEsIhMGp	.................................................................................Psh+tV+Vplhtsst..+t...s.c.t.s.pthpsssolAAATAAAIAssAPLlKsQpphpAplspVsphLpKLppspt.l..h.t.t.t....p.p....tp................................sphIsuAhp.tt...h.......hssst...h...c.t......t.....p.h.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	3	5	11
+15178	PF15325	MRI		Modulator of retrovirus infection	Coggill P	pcc	Jackhmmer:Q9BWK5	Family	MRI, or modulator of retrovirus infection, is a family of eukaryotic proteins that regulate the activity of the proteasome in the uncoating of retroviruses [1].	27.00	27.00	27.70	41.30	21.10	25.70	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.51	0.72	-3.07	14	32	2012-09-03 09:57:11	2012-09-03 10:57:11	1	1	25	0	17	32	0	99.20	66	70.21	NEW	TVYCMNEAEhVDVALGILIE.uRKQEKPhEpsslAGADKPEhSP....ssStSPtsSS.GusSE-EDsGpDu.sP..GLuPspsPuGScSACScSPEc...-EDsLKYVREIFFS	.TVYCMNEAElVDVALGILIE.uRKQEKshEQsuLsGADpPEhSP....ssSsSPaoSS.GSoSE-EDuGc-u.sP..GLSPSQtPuuSsSACSRSPE...E..E-EDsLKYVREIFFS...	0	2	2	2
+15179	PF15326	TEX15		Testis expressed sequence 15	Coggill P	pcc	Jackhmmer:Q9BXT5	Family	TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination [1]. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population [3].	27.00	27.00	307.70	44.90	19.00	18.60	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.65	0.70	-11.58	0.70	-4.73	12	63	2012-09-03 09:57:43	2012-09-03 10:57:43	1	4	25	0	32	57	0	220.00	40	16.72	NEW	N..hsKR..c+pGchKs.SpcsQo.spth..phshh.SKPulh.tlsphPlhct..+Schscs.s....pss...s-LcEpHsosspsuhlscLSpILQRADEASSLphLQEEocsCQNlLPLFVEAFERKQcCShcQILISR-LLVEpNLWsN.CKa+LKPsAlDoLVELQMMMETIQFIENKKRLLtGEPTFRSLLWYD-oLYuELLttP+GaQQQSsFYPuFQsRLKYNAFsELQpYHsQLIELh	...........................................................................................p........p...hh.tcst.h..thsp.slh.tppcsspls........pcsss.hpphK.pps.h.s...Hss.IsslSpILcpA-.susLphLQE.ThhCpshL.lhhchFphhQEssl-pIhIocE...llD..sl.pN.sp.hhLKPpAl-ohlEl.Mh.ETIpFlcNpht+hhsc.pFRuhLWaD.SLhsELltp.c..............................................	0	2	3	5
+15180	PF15327	Tankyrase_bdg_C		Tankyrase binding protein C terminal domain	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BY89	Domain	This protein domain family is found at the C-terminal end of the Tankyrase binding protein in eukaryotes. The precise function of this protein is still unknown. However, it is known interacts with the enzyme tankyrase, a telomeric poly(ADP-ribose) polymerase, by binding to it. Tankyrin catalyses poly(ADP-ribose) chain formation onto proteins. More specifically, it binds to the ankyrin domain in tankyrase [1]. The protein domain is approximately 170 amino acids in length and contains two conserved sequence motifs: FPG and LKA.	27.00	27.00	28.00	28.00	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.49	0.71	-4.08	17	95	2012-09-03 09:58:28	2012-09-03 10:58:28	1	3	38	0	50	89	0	166.70	50	15.10	NEW	s.cFuF..tpTslLDS.SAL+oRsp....Lu++.pp..+RAPsStuhRt....sR..ts.sthshs--ss.sWhFpDS....sppp+ss.p--u-.t.E.t+s.+ocpssssps.+lslFPGhDPSALKAQLRKRs-u........-u.s-t...ussQhSKSPKsPh.h.G..usRVLPPus-K-suSE-.sSPpWL+-LKSKK	...............................t..DFSF.I-pTplLDS.osh+oRsp.Lu++.pt.+RAPs...........Rsuto..t.s.ts-sD.sWhFpDS....sptp+sP.pp-p-..EE.pspRochosso+s.+lslFPGhsPSALKApL+pRscu..................-S.upp...ShsQpuKSsKsPh.h.G..tshlLPspsEKspt.....SEt.sSPpWLptLK.KK......	0	2	5	16
+15181	PF15328	GCOM2		Putative GRINL1B complex locus protein 2	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BZD3	Family	This protein family is named Putative GRINL1B complex locus protein 2. GRINL1B is short for: glutamate receptor, ionotropic, N-methyl D-aspartate-like 1B. The name indicates what sort of receptor it is thought to be, a ligand gated ion channel specific to the neurotransmitter Glutamate. This family of proteins is found in eukaryotes. Proteins in this family are typically between 325 and 463 amino acids in length. The protein is thought to be the product of a pseudogene with a role in helping assemble a gene transcription unit [1].	27.00	27.00	27.00	27.00	26.40	26.70	hmmbuild  -o /dev/null HMM SEED	223	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.46	0.70	-4.60	48	192	2012-09-03 09:59:30	2012-09-03 10:59:30	1	2	70	0	83	176	0	245.50	28	63.40	NEW	hLcRQp+lLpN.........++hlpcLPDKGcKIpchhp+lpstlsc+.c-l-pp............uphhpsLslssp....tth..sphphpttt.pcphhphsshh.tsp..sppcpstht.hsQ...........ss.ctpthhhhpsssshhst...........................ts.t-htphh......t......t..............................................p....................p..p+ht.hhpppp++..................................cshchcsKhpshpssp	..................................................................................................hpcp.phlpp.....................................cchhtphs-htp+l.p.htcl.ht.tpp.c.lcpp............sth.psls.s..sh....tth..sshphpttt.p-thhphpph..tss..p....p-ppp.hpssQ..s.hh+hp.tpopctsspVhhEhotplhsp...........................tshpEuspthpt...tEhshp.p+-pcluEl.......p+hltthppEpptL..ph...........................................h..t...s.u-ppc....pp.LEc.tsssL+E+I+HLcDMlcsQQ+KV+tMl.............................tEs.Ehps+hc...........................................................................................................	0	13	17	43
+15183	PF15330	SIT		SHP2-interacting transmembrane adaptor protein, SIT	Coggill P	pcc	Jackhmmer:Q9Y3P8	Family	SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.	27.00	27.00	27.40	27.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.69	0.72	-3.90	36	122	2012-09-03 10:10:56	2012-09-03 11:10:56	1	3	34	0	64	132	0	102.10	28	42.21	NEW	hhLhslhullL.Ll.Lshslhtahtt++pp+ssph...........................tslE-sPlYGNLshhps...sshspsshcphpspPppSspspp...Ehss.s..hscpphsYASLshss.sp.c	...hhLhsllulLL.Ll.lsssLhtWphh.p+ppKhsph............s......ppsttsh.E.ss.h.YuN..Lshh.s...tshsppshpphps..Pppusptt....Ehss.s..hsccphsYASLshss.tt.....................................	0	5	5	14
+15184	PF15331	TP53IP5		Cellular tumour antigen p53-inducible 5	Coggill P	pcc	Jackhmmer:Q9Y2B4	Family	TP53IP5 suppresses cell growth, and its intracellular location and expression change in a cell-cycle-dependent manner.	27.00	27.00	77.00	38.00	23.80	21.50	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.46	0.70	-4.43	14	41	2012-09-03 10:11:55	2012-09-03 11:11:55	1	3	28	0	22	33	0	185.80	51	80.98	NEW	pQPVSKlIERNRLKMVLKNLSLLKLLKSSNsRIQELHNLA+RCWNSLLRVPKILpISSGsssVssKscQNNcEhQE.AsssccpLESKKhE.SsuEPK.....t.csc.tst.pstsptSPuAVsp+EcQhEsElP+TS+ucGL..s..PGApu+QssTtsPpVlhLKTapp+TPhtDhKQL-.sADQasWFEGLPTRIHLPGPRVMCRuSoLRWVKRCCTRFCSASL	...........................QslsKhlERNRL+hVLKNLSLLKLLKSSN.RIQELHpLA+RCWpSLLp..VP+ILpISSupsssss+scQsscEhQE.hssspcpLcSK+l-.usu-PK.........c.ps..t.thpsttptS.uAhs.+-cphcs-lP+Ts+spuL..s..ssApu+Q..TcsPpllhlKsappRsPhtch+Qh-.hAcQahWFEGLPTRIHLPuPRVMCRuSsLRWVKRpCTRFCSASL........................................................	0	1	1	5
+15185	PF15332	LIME1		Lck-interacting transmembrane adapter 1	Coggill P	pcc	Jackhmmer:Q9H400	Family	LIME1 is a family of eukaryotic transmembrane adaptors. It plays an important role in linking BCR stimulation to B-cell activation and is expressed in primary B cells. LIME localises to lipid rafts in T cells in response to TCR stimulation [1], and is phosphorylated by Lck and recruits signalling molecules such as Lck, PI3K, Grb2, Gads, and SHP-2 [2]. LIME acts as the transmembrane adaptor linking BCR-induced membrane-proximal signalling to B-cell activation [3].	27.00	27.00	32.50	35.30	26.00	21.00	hmmbuild  -o /dev/null HMM SEED	228	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.71	0.70	-5.12	8	37	2012-09-03 10:12:49	2012-09-03 11:12:49	1	2	22	0	14	35	0	187.90	51	73.69	NEW	LCTsC....HR.D-.L..RKpupRQpuRLQGohMPuEhSLLRQspLCSLSKSDTRLHELHRGPpsS+A...RPASMDLL+PpWLEsSRussRs...PsAFsHRELPQu.PuA....s.husEATYSNVGLAAIPRAu...........LAAsP.VV................AEYAClQK.hKGT-pGP.....Qs...LpQuKAclpPAsQVDILYSRVsKPKRRssuPs.....sDQ.DPKupusILsL........GSD.uYEsL.PLpGpuh-su.LENVYESIQE	.................................Ktspcppst.psshhss-hsLLRps+LCSLSKSDTRLHELHRGspsohA...RPASMDLL+P+WLEhSRusops.ssssAFs.ppLPpA.PAA..hssshusEATYSNVGLAAlPRuS...........LAASP.VV.....................AEYAslQK.hKGTcpGs.....Qp....tQ.KschhPAsQhDlLYS+lpK.t++s.tss.....ss..s.pstts...h........tss.tYpsh.s.hu.thppt.hENhYESlpE...........	0	1	2	2
+15186	PF15333	TAF1D		TATA box-binding protein-associated factor 1D	Coggill P	pcc	Jackhmmer:Q9H5J8	Family	TAF1D is a family of eukaryotic proteins that are members of the SL1 complex The SL1 complex includes TBP and TAF1A, TAF1B and TAF1C, and plays a role in RNA polymerase I transcription [1,2]. Alternatives names have included 'JOSD3, Josephin domain containing 3'.	27.00	27.00	153.10	70.30	23.90	23.00	hmmbuild  -o /dev/null HMM SEED	217	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.89	0.70	-11.71	0.70	-4.55	12	58	2012-09-03 10:13:26	2012-09-03 11:13:26	1	2	34	0	33	42	0	201.10	57	79.67	NEW	SuSSLF+TQClP.oPpp+pR.ss..Rp.slpustslp.pDSSSDSS.hE.P.pP..LsLKA.IFE+FKK+....KK++.K..RKYKP...Tt+.h.GRPcG++s..s+hSp..h-K.+plKDKG.pFPFlESE.s.+KsLPW+KILoaEQAVARGFFNYlEKLKYEpHLKESLpQMcsGEDLEcEDh-sR+YKYLDDDGuISPIEEsssED-.ssss..cp.s..-CDlKLV.E.sS.FIlSo-hP+K	...............SsSSLFKTQClP..hSPKpppR.Ns.hRK.hVcss.tsVpspDSSSDSS.hE.P.hP..LTLKA.IFER.FKp+.p...K.K+KK..RK...Y+P....oGRP+.GRP........cG++s.........sphS...l-K...KQh+-+GssFPFLESE.s.cKslPW+KILoaEQAVARGFFNYlEKLKYEaHLKESLKQMsVGEDLEcEDhDSRRYKYL.DDD...GSISPIEEStsEDE.sssph...cp.s.-CDIKLV-sopFIlSSEhPp.....	0	1	2	6
+15187	PF15334	AIB		Aurora kinase A and ninein interacting protein	Coggill P	pcc	Jackhmmer:Q9H7T9	Family	AIB is a family of eukaryotic proteins necessary for the adequate functioning of Aurora-A, a protein involved in chromosome alignment, centrosome maturation, mitotic spindle assembly and aspects of tumourigenesis. AIB is likely to act as a regulator of Aurora-A activity.	27.00	27.00	191.40	185.70	17.90	17.10	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.08	0.70	-12.13	0.70	-5.37	12	28	2012-09-03 10:14:07	2012-09-03 11:14:07	1	1	23	0	14	29	0	319.50	66	92.02	NEW	QTHLIKsuTKMLTLhPGERKspISFTQRphPsAGsRQTSIASFFTLQPGKTNGGsQ+SVSSHtESQhNKESKcDsTQL.DHLhQGLcDDChAsPLATSTPADIQEA.GLSPpShQ.sSGHHphtTPhLThhSL.QP-TL.VCAG-SKASLAhSFTQDlEsSCLLDQKEuc...DSShK+EWLpGSK.K.N.hQuhERHs+PsGGKsHQsLDKsKlE.KVSAKENRQuPV.lQTYR-.SaSGcNT.uVKQSPCPVslFSWDSE+sDKDSWSQLFTEDSQGQRVIAHNoRAPFpDVTNspNQGLGQFPsSPtAQsQtsssph.NLQPDLLFTQDSEGN	QTHLIKPGTKMLTLLPGERKspIsFTQRRsPssGI+QpSIASFFTLQPGKTNGuDQ+SVSSHsESQlNKESKKsATQL.DHLI.GLtcDCMuuP..LATSTsADIQEA.GLSPQSLQ.TS.GHHRhtTPFLT.L..SLhQPDTL.sCAG-SpssLAhSFTpDLESSCLLDQKEtc..tDSupKtEWLHGSK.K.N.YQuME+HsK.PGsKCpQPLsKTKLE+KVSAKENRQAPVhLQTYRE.SWsGENs-uVKQSPCPVSVFSWDsE+NDKDSWSQLFTEDSQGQRVIAHNoRAPFQDVTNNhNpsLG.FPNSPWAQCQ-c....ssp.NLpPDLLFTQDSEGN.	0	1	1	1
+15188	PF15335	CAAP1		Caspase activity and apoptosis inhibitor 1	Coggill P	pcc	Jackhmmer:Q9H8G2	Family	CAAP1, or caspase activity and apoptosis inhibitor 1, is a family of eukaryotic proteins involved in the regulation of apoptosis. It modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.	25.00	25.00	25.10	27.30	24.80	21.90	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.52	0.72	-9.12	0.72	-3.77	14	90	2012-09-03 10:14:51	2012-09-03 11:14:51	1	1	71	0	60	86	0	61.70	53	16.01	NEW	shKPluhYIpDK+EMLcQCFpVlGEKKLpKMLPDhLKssolc-lccLCh-QLphlScKplh..pIL	...sLKPlSaYIsD++EMLpQCFsllGEKKLpKMLPDlLKssSl-EIKcLC.EQLEhLScK+lLpIL...........	0	13	17	36
+15189	PF15336	Auts2		Autism susceptibility gene 2 protein	Coggill P	pcc	Jackhmmer:Q9HAH7	Family	Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism [1] and with influencing the number of corpora lutea produced by breeding sows [2].	23.00	23.00	23.10	23.10	21.40	22.50	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.42	0.70	-11.48	0.70	-4.30	17	176	2012-09-03 10:19:03	2012-09-03 11:19:03	1	3	48	0	86	152	0	197.20	53	25.25	NEW	KPGKWCAhHVplAWQIh+....H.QQKlK..QMQLDPHKL-.huhKhDhhSRPPuPulFsuhHaPpDLARP..LFSu...o.GuuHPussPFGPssHH.uuFL.PsuHL..DPFSRsuoFuGLGsLuSsAFG.....GLGs.sLo..ssSlFu.K-GP.slpsh...uuP.HEsWNRLHRTPPSFPT.PP......PWPKsuDsERsuusssH-tc..........R-s-K.........uK--+-..RDhL-KsR.Hss+uSP	....................KPGKWCAMHVpIAWpIY+....H.QQKhK...MQhDPHKLD.huhK.-hLuRPPu...Pu.......l..F....uu.......lt...aPpDL.ARP...sLF.S..u...s..G..A.sHP.u.usPF.GP.s.P.HH.usFL..PuuHL...-PFuRPooFuGLuuLuusAFG.....GLGsPols...ssSlFupK-uP...ultsF.......usP.H-.PWN.RLHRoPPSF.P..TPP......sW....KPs.-h..ERou.u.hss+D+-................R-s-+c...ph.sK-....-+-...R-.l-+p..h.s+sSP................................................	0	8	15	39
+15190	PF15337	Vasculin		Vascular protein family Vasculin-like 1	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9HC44	Family	GC-rich promoter-binding protein 1-like 1 or Vasculin-like protein family 1, is likely to be a transcription factor. The domain family is found in eukaryotes, and is approximately 90 amino acids in length.	27.00	27.00	27.90	48.40	22.40	21.10	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.33	0.72	-3.52	16	123	2012-09-03 10:19:58	2012-09-03 11:19:58	1	1	40	0	69	117	0	95.20	68	21.42	NEW	-s-hLSpSLEAEH.RLLKuMGWQEYsENDEshLPLTEDEL+EFphKoEQL++NGht+NGhLtp.pshs.hFssWRsoscschpcspDoETSS.S-TS.DDD	...............t.s-VLSpSLEAEH..RLLKtMGWQE.sENDEsChPLTEDEhREFQshoEQLp.+NGhpKNGhLps..hhss.hFuPW+sosht.s.-s..pDTETSS.S-TS.DDD.	0	5	8	20
+15191	PF15338	TPIP1		p53-regulated apoptosis-inducing protein 1	Coggill P	pcc	Jackhmmer:Q9HCN2	Family	TPIP1 is a family of eukaryotic proteins whose expression is induced by wild-type p53. Ectopically expressed TPIP1, which is localised within mitochondria, leads to apoptotic cell death through dissipation of mitochondrial A(psi)m. Phosphorylation of p53 Ser-46 regulates the transcriptional activation of TPIP1, thereby mediating p53-dependent apoptosis.	27.00	27.00	66.20	66.20	23.40	17.70	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.04	0.71	-10.68	0.71	-4.26	2	7	2012-09-03 10:20:35	2012-09-03 11:20:35	1	1	5	0	1	11	0	101.70	89	91.40	NEW	MGSSScsSFRSAQASCSGsRRQGLGRGDQNLSVM.PNGRAQTHT.GWVSs.LVLGAQVHGGCRGIEA.SVSSGSWSSATVWhLTGLGLGLS+PFLPGshVLRDRPLtSAhELSYDQKKA.LpLQ	.MGSSScASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSs.LVLGsQVHGGhRGIEA.SVSSGSWSSssVWhLTGLGLGLS+PFL.GshVLRDRPLtSAhELSYDQKKA.LpLQ........	0	1	1	1
+15192	PF15339	Afaf		Acrosome formation-associated factor	Coggill P	pcc	Jackhmmer:Q9NQ60	Family	Afaf is a family of single pass type I membrane proteins. Afaf is a vesicle factor derived from the early endosome trafficking pathway that is involved in the biogenesis of the acrosome on the maturing spermatozoon head.	27.00	27.00	91.10	90.50	21.50	19.50	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.60	0.71	-11.32	0.71	-4.72	11	38	2012-09-03 10:21:37	2012-09-03 11:21:37	1	1	22	0	16	39	0	182.00	62	66.58	NEW	PANEKoGNYYKDIKQ.YVFTTQNPN.GopSEISVRAT...TDLsFuL+NaKhlstosh....tppusE-csshpEspcsphp+oT..PN.PAFWTMLAKAlNuT.ssp...--KDQLFpPIPsSDlNATsEDplu-Lp-lKLKLMLGISLMTLhLFlhLLAhCsATLYKLKpls.K.spES.QYSlNPELAoLSYFHPSEGVSDTSFSKSAESS	....PANEKoGNYYKDIKQ...YVFTTQNPN.GTpSEISVRAT...TDLsFuL+NaKhhNtTsh.....tpssptpt..pE.pcpp.pcsT..PN.PAFWTMLAKAlNuT.sst...--+DQhFpPIPsSDlNu....TpE.Dphu-Lp-lKLKLMLGISLMTLhLFVsLLAhCsATLYKL+plphK.sCES.QYSVNPELATLSYFHPSEGVSDTSFSKSAESS..............................	0	1	1	1
+15193	PF15340	COPR5		Cooperator of PRMT5 family	Coggill P	pcc	Jackhmmer:Q9NQ92	Family	COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyses the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.	27.00	27.00	93.50	93.30	19.20	18.70	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.47	0.71	-11.17	0.71	-3.84	8	37	2012-09-03 10:22:24	2012-09-03 11:22:24	1	1	26	0	19	38	0	146.60	76	88.73	NEW	EAGhATADHSG..EpETEtAsDRLupGAQSlPs-sPs+GEGopuEEEGa...AhDcc-uDGEhNsWELs-Gs..ssPPpEpsus.lFNEDWDhELphDQGN..PYDADDIQGSISQElKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED	........AuFATuDHSu.pERETEKAMDRLApGAQSlPND.uPA+GEGTHSEEEGF...AhD-EDSDGELNTWELSEGs..sCPPKEQsuD.LFNEDWDLELKADQGN..PYDADDIQtSISQElKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED	0	2	2	4
+15194	PF15341	SLX9		Ribosome biogenesis protein SLX9	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NSI2	Family	SLX9 is present in pre-ribosomes from an early stage and is implicated in the processing events that remove the ITS1 spacer sequences. In eukaryotes, biogenesis of ribosomes starts in the nucleolus with transcription by RNA polymerase I of a large precursor RNA molecule, called 35S pre-rRNA in yeast, in which the 18S, 5.8S, and 25S mature rRNAs reside, while RNA polymerase III transcribes a 3'-extended pre-5S rRNA. The 35S precursor also contains external transcribed spacer elements (5' and 3'-ETS) at either end as well as internal transcribed spacers (ITS1 and ITS2) that separate the mature sequences [1].	27.00	27.00	28.30	27.30	25.00	26.30	hmmbuild  -o /dev/null HMM SEED	121	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.86	0.71	-3.67	125	252	2012-09-03 10:23:41	2012-09-03 11:23:41	1	5	220	0	174	248	0	135.90	22	65.24	NEW	psththoKK-....Kpph.K+ppFlpK....lpps..t.sp..........p....pp+p...++R........tpp...tls.s.....shcsLtcuL..Pp...........................................ttptth.pptt.....................hpppthst.........+p+cplh.ppEtpRFsplLsp.sa.................................................pssPhuAlcpalppsh	............................................................t..thh.oKK-....Kpph.++ppalpK....lptt....sp...................p....pp+p...++R...tpp.....tls.s...sLpsLt-uLP-................hp...t.............................tttp.t..ptts.............................hppp.hst....................+p+cplh.ppEppRFpplLsp.sa...............................................................pssPhuAlppalppp...........................	0	49	92	138
+15195	PF15342	FAM212		FAM212 family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NTI7	Family	This domain family is found in eukaryotes, and is approximately 60 amino acids in length.	27.00	27.00	29.60	29.60	24.90	16.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-9.13	0.72	-4.36	8	105	2012-09-03 10:24:18	2012-09-03 11:24:18	1	2	41	0	47	82	0	59.60	62	20.65	NEW	Rs+P+SopsssL-phpuhs.ts-ucDWTooLhSpSRNRQPLVLGDNsFADLVtNWhDLPEss	..........................hP+Sps.ssshpphpuhc.hs-s-DWTooLhSRGRNRQPLVLGDNsFADLVtNWhDLPEh...	0	2	6	17
+15196	PF15343	DEPP		Decidual protein induced by progesterone family	Coggill P	pcc	Jackhmmer:Q9NTK1	Family	DEPP is a family of proteins expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels are found during the first trimester.  Its expression is induced by progesterone, testosterone and, to a much lower extent, oestrogen. The family is alternatively known as fasting-induced gene protein, FIG.	27.00	27.00	30.40	29.60	19.80	19.60	hmmbuild  -o /dev/null HMM SEED	188	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-11.21	0.71	-4.68	10	32	2012-09-03 10:25:33	2012-09-03 11:25:33	1	1	24	0	16	26	0	159.20	52	85.86	NEW	GGPspEPP.......uSPSLDDYVRSICQLAQPTSVLD..cAsstspss+spR.PAp.............usEKSsPssSLQDITs+FSGQQPsLPtssTsDPLDWLFGESQEKQsS+RDhsRRTGsSAssWGsHRQhDoGKutusPRGRhC-ARsPGHSLuRhSpDtpQutp..Sh..suppstpssuSstpsRsSSlLRTLa.HLPVIHEL	.......GuPGQEPP.......sSPSLDDYVRSIspLAQPTS.VLD..cATApupPpsPaR.PAp................uscKupPAsSLpDlTs+FSuQ....QPsLPhssssDPLDWLFGcSQEKpsspRDhsRRTGsSus.hssHRQh-ssKs.sssRGRhs-A+hstaSLsR.spchpQs....S...s.tp.tpthuu..tsp.uShL+oLh.cLPVIaEL.............................	0	2	3	5
+15197	PF15344	FAM217		FAM217 family	Coggill P	pcc	Jackhmmer:Q9NTX9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 329 and 507 amino acids in length. There is a conserved YPDFLP sequence motif.	27.00	27.00	85.50	33.40	20.10	23.60	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.39	0.70	-4.80	21	73	2012-09-03 10:26:04	2012-09-03 11:26:04	1	2	32	0	40	62	0	213.10	41	51.55	NEW	SDLSDSERls.lssSPhTPPDLsLRAEEIDPVphp...cPtpupsps-ahYPDFLPPPFNSWDL+chAlhhpoEshpsslPpssuhLtKYI-RLLQLEWLQhQTIQsEKsK.ss+uRssousus....ptshKSPG.+oKhhsusls.cs.s.hQ.p.Gs.sKsssp.....R.....KpshtppcscPshht.apsSspshchhus..oR....sS.+Qosph+p.....ctK++cssK.ss+.QphshsCs-...susKhposuNlRhPp	...SDLS-sE+hs.h..S.h...p.sDLNL+sEpI-sVp..............c....sh...ptcsp..a.YPDFLPPPFsohDL+chAl..poEshptsls.stu.lt+hIsRLLpLEhLQh.TlQpE+s+..hs.sp.sTssuo....pts.pS.u.psKlhtstls.csLs.hQ.p.us.sKot.p...........R...........Kps.tppchc.stht.aphSsts.chhhs..oR....sS.+posps+p..pppcssK.ssK..phhs.sCp-....SsKspsstshp.............	0	2	5	10
+15198	PF15345	TMEM51		Transmembrane protein 51	Coggill P	pcc	Jackhmmer:Q9NW97	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 253 amino acids in length.	25.50	25.50	25.60	25.50	25.10	25.40	hmmbuild  -o /dev/null HMM SEED	233	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.68	0.70	-4.66	17	64	2012-09-03 10:26:44	2012-09-03 11:26:44	1	2	40	0	32	46	0	218.10	49	87.87	NEW	puuGSHYALsALGlGhlALGllMhVWslVP..Gtus..u.ssssssu.ss.ts..sss......tt+oKoSSVAaVLVGsGlhlLLLSlCLulRsK++pppst.p....ptpsss....pp.spppEc.t.-.tsupYsVPSYEEVlsost...ss..ppssh..ptspS...pLPSYEsLsshsp............spss.....s.....sssth.ssssps..........PsRpsSRsuRhL+PL+VRRIKS-KLHLKDhRlslt....p.ss..p.sslTIEPLTPPPQY-	................uNGSHYALTAIGlGMLVLGlIMAhWNLVP..GhSs..up+ssspu.N.po.suuG......hhKSKTFSVAYVLVGu.GVhLLLLSICLSIRcKR+pRQu--...chQptsussPpspcpcuQpE-....E-suuRYhVPSYEEVMsosh..sps..Rttpp..psphS...hSLPSYESLsulDE.................ssss.....ssputspssssps..................PsRpsS+..hu..++L+PLKVRRIKSEKLHLKDFRlsLs....s..ts..h.sPsoIEPLTPPPQYD................................................................	0	2	5	13
+15199	PF15346	ARGLU		Arginine and glutamate-rich 1	Coggill P	pcc	Jackhmmer:Q9NWB6	Family	ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.	27.00	27.00	29.20	30.20	26.80	22.80	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.52	0.71	-11.29	0.71	-4.43	19	163	2012-09-03 10:27:43	2012-09-03 11:27:43	1	6	106	0	113	158	1	130.50	45	54.99	NEW	pEhEtKllEEEsA+RVEchlcKRVEEpLp..p-EIcpElpRRlEEu++th-cphht-lE+c+cttlp-t+p+EEcE+pc+E-LEclhpENpRKlEEAQ++.AEEchph.......hEEph+.hE.......-Rt+hcp-cc++h+-.E.....Qth...lLGKppoRPKLSFuL	...........pEhE.KhlE.EE.sA+RlEchltK+VEEcLp..p-EIcpEl.RRlEEu++hhccplhtpLE+p+pttlttt+t+.....E............EcE+pc+EELEchLEENpRKltEAQtKhAtEp.th.EEphp..E.......pR.+hcttcp+p.cc.E.....Qhh.....lLGK.s.p.....uRPKLoFsh...................................	0	37	59	85
+15200	PF15347	PAG		Phosphoprotein associated with glycosphingolipid-enriched	Coggill P	pcc	Jackhmmer:Q9NWQ8	Family	PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.	27.00	27.00	30.30	94.20	25.70	19.70	hmmbuild  -o /dev/null HMM SEED	428	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.47	0.70	-12.24	0.70	-5.38	5	46	2012-09-03 10:28:35	2012-09-03 11:28:35	1	2	37	0	27	40	0	401.30	61	99.17	NEW	MGP-GGLLSoGpVHIIlWGSLAAVuThLlITFLIFLCSSC-REKKPKQQNGDHENLMNVPSDKEVFSHSVTSLATDsPASSEQNGGLSNGDILSEDSTsAChQPYEEVQTSlSDLLEuQDSlGKSlKCHQSRELPRIPPNsTlETILSTRNsEsDQGLGMEGPYEVLKDSSSQENMVEDCLYETVKEIKElGAoAssEKupsG+us..uusAs+Es.uslsts+lESAEYASVDRNKKSRQSsNuESlLGNosDlEEEAPPPVPVKLLDENENVQEKEs-Es......EtpATEGsu-ssKRLSSLSYKSREEDPoLTEEEISAMYSSVNKPGQA.R..hsPESoYTCIpElAPpRSPSSCNDLYATVKDFENsPsu..ThPPu..u.RsNGEPEPDYEAIQoLu+DEERss.hPpos+lshspENDYESIGDLQQsKDVTRL	...........MGP.GuhLu.uGQh..Q..lsLWGSLAuVuhFhlIo.FLIFLCSSC.-REKKP+..p..puGDHENLMNVPSDKEhFS+SVTSLATDAssSSEQNGuLTNGD....ILSEDSTh.TChQHYEEVQTS.uSDLLDSQDSoGKs.KCHQSRELPRIPP-uAVDThLssRssDuDQGhGhEGPYEVLKD..SSS..QENMVEDCLYETVKEIKEVuAssp.-+G.....psu+u+.......Ss.sulKElsuPpsps+...s-F.AEYASVDRNKKCRQSsNsES.........lL.Gso..sDs........EEEuPPPVPVKLLDENENlQEKEs.tps.......EcpAsEsT.u.-ssK.....Ra.SSL..SYKSREEDPTLTEEE.IS.A.MYSSVNKP.G.......Q.....s.....h.....p......p.............ssES......s....YosIpt..sspRSPSSCNDLYATVKDFEKsPsu...ohPPA..u..RPstE.PEPDYEAI...Q...oLsREEEKss.tssu.ppshssK.ENDYESIGDLQQsRDlTRL.....	0	1	3	10
+15201	PF15348	GEMIN8		Gemini of Cajal bodies-associated protein 8	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NWZ8	Family	GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm [1]. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer [2].	27.00	27.00	31.30	31.30	26.80	26.80	hmmbuild  -o /dev/null HMM SEED	209	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.70	0.70	-11.49	0.70	-4.28	39	92	2012-09-03 10:29:33	2012-09-03 11:29:33	1	2	65	0	64	84	0	197.70	35	87.38	NEW	psWaspssYu+.................YWpHYppAMtWhppHptA.hptthpthhssshhhsss.....psphsppstp.........................t.t....s....p.tttp.....t.pp.cc-t.-oco-sc.hcsDhs...NMElTEEL+QaFA.pTE+HREEh++.....QpQ...l-scp.-s..........YVpAD+sLhhs.h+.SspsPsEpPucpRpAE.MK+LYG.cuAs....KI.AMEsAlQLsFD+pC.Dc+pPKYWPlIPLKh	.......................................................................................Whtp.hatc.......aWpHYppAhtWhppHp....p..ht.hht.shhhs.s.....psphsppttt...............................................................t.tp...t..t.p.ptpp......t.pp.c--.-o-SDs-.lEsDlo......NMEITEELRQYFA.pTERHREEh++......QQQ...l-scchcs.....................YVsAD+sLhhstp+..SspsP.sEcPu..c+RpAE.MK+LYG.csAs....KI.AMEsAlQLoFD+ps.DcKpPKYWPlIPLKh.....................	0	18	22	40
+15202	PF15349	DCA16		DDB1- and CUL4-associated factor 16	Coggill P	pcc	Jackhmmer:Q9NXF7	Family	DCA16 is a family of eukaryotic proteins that interacts with DDB1 and CUL4A. The family may function as a substrate receptor for the CUL4-DDB1 E3 ubiquitin-protein ligase complex [1].	27.00	27.00	349.80	349.70	20.50	18.80	hmmbuild  -o /dev/null HMM SEED	216	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.68	0.70	-4.98	2	16	2012-09-03 10:30:57	2012-09-03 11:30:57	1	1	14	0	8	12	0	207.10	95	100.00	NEW	MGPRNPSPDPLSESESEEEtNANYLNESSGQEWDSSEtEDPVVPNloPLESLAWQVKCLLKYSTTWKPLpPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVP+LEPIPEWPPLASCGVPPFQKPLpsASRLSRDHATLNGALQhATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVN+LLTASL	MGPRNPSPD+LSESESEEEENhSYLNESSGEEWDSSEEEDsMVPNLSPLESLAWQVKCLLKYSTTWKPLNPNSWLYHAKLLDPSTPVHILREIGLRLSHCSHCVPKLEPIPEWPPLASCGVPPFQKPLTSPSRLSRDHATLNGALQFATKQLSRTLSRATPIPEYLKQIPNSCVSGCCCGWLTKTVKETTRTEPINTTYSYTDFQKAVNKLLTASL.....	0	1	1	1
+15203	PF15350	ETAA1		Ewing's tumour-associated antigen 1 homologue	Coggill P	pcc	Jackhmmer:Q9NY74	Family	This family of proteins is found in eukaryotes, where members are expressed at high levels in the brain, liver kidney and Ewing tumour cell lines. Proteins in this family are typically between 648 and 898 amino acids in length.	27.00	27.00	75.90	40.40	21.10	20.50	hmmbuild  -o /dev/null HMM SEED	814	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.85	0.70	-13.37	0.70	-6.52	8	53	2012-09-03 10:31:34	2012-09-03 11:31:34	1	2	34	0	31	50	0	614.10	41	89.43	NEW	RYETPKRlLKMDLLSSTFSSP.NDPDGQNDIFWDQNSPMTKQLGKGRKKQIYoTDSDEISHIVNRIAPQDEKPTTNSMLGhWIGETAIPCTPuVAKGKSRAKlSCTKLKTQNQEEELMKLAKQFDKNMEELDVIQEQDKRNHDFIQMISEsETLNNYKDNVQMQhLp-I...VPEIDsuIIKKPhKtNTKISVs.NDQsSSQKPFDQNAEAAFNAIFDGSTQKCSGQLSQDLSDAFLNTSNTTFGKKssLKEEKIIoNETlVTE+L.NK.......TPsSLSsQVDTPsMTKSCVTSsTKEPcshsKalDsFsTSDFEDDWENLLuNEPFVMQNlEhsELhP.u.KTsQhsDQKuICoFN.uKNDKSKSthNoSLDsRLRDSKILQDLPScTpNpELhDAtKapF.P...sPNDKPNKL.S.TGNKhKFEKSFNKlVlQDKIQD...sAlASsLTKVKEDhpT...K...Fs...ss..SpKKSuLNTGYSN-Q.......KNKsIFNQSFKsPAslcPFGSAsLusET.SVsNsNQTNASKLsSFFDDWNDPSFANElVKACHQLEsTWEADDVDDDLLYQACDDIERLTQQQDlRKDSKTSEShL-lNNSSpHGA.KNhFTTSKQuSQLlQSKHLNLuSISsp.T.SlTNSSQlsKSVKMEKGEhCGNSPuFLGATTNLoIYSKNSssQhsN..VuhNNTcVPlQVNSSKSlLsGSSSLNVsSDHMoTEIATspKKLSTppLSHsTlTDEuQocLN+sV+hSKYTFTKhKNsQhhSQhNQNCl.sGSlSDTKIoQsLEKNK..T..VNsLhGcAVQQQSLh+.hSESLKQPSKEEEEKNRKYSPEEIQRKRQEALVRRMAKA	............................................................................hcTPKRhhphchhSss.FSSP.NDsDsQp-IFWD.sSPhTppL.GcuR.+KQh.hspsosEIScIVN..RIAPQDEK.Ps.s..s..ShLshWIG-sAIPCTPsVsKtKSRsKhsss+.h......K.spspEEELMKLAKQFDKNM.ELDslQEQspcsasFhQhhSEsthL.ssa+D.shphp...shpsh...lsEls...ps..t.cshctso.pluh...pspsSSQKshD.sAEAAhsAlFDGSTQKCSGQLSQtLs.-s.hssopshh..hcpss....LhcEp........st....cohl...-ph.sc............oshulos......psDoshhspSp.lT....ppc..s....t.h.c.....s.....hsssDF-DDW-..s.hLss-sFsMQ.sp.sELhss..cosp....s.....ppth..ht..spsspshsthsts.....th.htssp.h.shsSph.stph.ss..p..h..pst.c...pl....tNp.ph.pps...h...sch.p...h..stshpphpEs..hs.p.........s..stccsshspt..sppp.......ps..s.h....pshpsssphp..sShtlspps....thsp.spppssK.s.s...aDDWNDPphusEllcthpp.-shW-u.sD..DDDLLYQsCDDlE+LTQpQshpcssctoEs...hs.sS.pGt.ps.hshScpt....p...hhQs.cHh....N.ssh.Shp.h...o.hpps.phsK.hthp.c.t.htsssp.hss.pNLoh..t.ss...p...h..sssssshthstop.hhstp.s..h....tpsthtsphs...pphpsppLstpshsst.sp..st.sp...st.s.casFp+hKssp.h.phsps.h.ssphs.sschh..pthtpp+..s..ls.shhtp...s......pp...h+..hSESht.ssp..t..pEE+N+KhS.EEIpRK+QEALsRRhu+.......................................................	0	2	5	13
+15204	PF15351	JCAD		Junctional protein associated with coronary artery disease	Coggill P	pcc	Jackhmmer:Q9P266	Family	JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells.  The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localises close to the apical membrane in epithelial cells. This family is found in eukaryotes.	27.00	27.00	191.40	27.20	17.50	17.20	hmmbuild  -o /dev/null HMM SEED	1356	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.69	-13.15	0.69	-14.27	0.69	-6.96	15	60	2012-09-03 10:32:28	2012-09-03 11:32:28	1	3	35	0	36	53	0	1002.50	39	97.42	NEW	MYSVEDLLISHGYKlSRclPAP+E-ch-G+ppARocsRAGpG.LLNGCEDGsAAhspSK....suhG+GalS.soE......s++p.sPRuHsEsQS.sSAuRsSEuGFYcQPsLsWSSQPQoucDpAY.RRR.GQ-sSu.lLGPRDR--LEsRGMAQAHSLPsHsREGPWEVGGRTEpVMKKAVWEEELRMuGPuKWQNlSLESWNQPRKLGRQMSDGDGEKLFQD....LYPFhpGEcsLsSQsKGKSQSLPRVLSPESLSChEIPIPLNDGHhPuVPKMPsYPPNCAPsLEsTRNsEKuGSSsPLPRPKFGRPLKPPS..YsSHppSRuGsEsSchpDSpQsD...hsssh...sppP.RpEhsssDsGLEPPVYVPPPSYRSPPQHIsNPYlE.DssP+sVsuGppQQpps...sE+suAusplPuGshuoGsEYGAusp.SPpGh.spPRPsssa-uSVQYIPFDDPRIRHIKLApPpGFs--sKh--psYsuuPlsssEPApGptQpDGAlhsPpulssssGsERu....ssh.AsPSPpWLWGQLPRDuENuGhPDQRDHCss.RGQ.PsspGSp+t+sEG.VSSPsPQ.GESTCETpTKLKKFE..TGhQTKKSSKKKhNETIFCLVSIPVKSESHLPDpDpNNNDLKQSADKKNGhDKSsALQEQSLLSMSSTDLELQALTGSMuGRTEhQKQ-LGEPE-sKQTNDLRFIHPsKHRELKYSGSWPGHQYRDQQTQTSFsEESKSsQhLPupKsGuss.cssLoP+psDP.......sA.S-.sphHsALuSSDpsQRPsAhsLKGQhS.LSPSSNSAFSRTSsshsQAPsPKAupoQP...shDspG+suuPsP+uEVVKGEo.T.GPCNS+QLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESusSS......SsSuSE....-S-sEhppEspAssps+shGhpcsSt-hRsctts+tls.EcPsh+SGRVKSKSESWSEE.csG..aspupP.S..GsspstsGRGpshhsAcGSLlsEp+cQEscsRhschslSPuPV+R.h..SSRu..SDs+PsssupsAE.REPQEspcLss.....shsSVplSpuuPPcssuutERuo..slsLSLuuKsRGLSAPDLRSVGLs.u.EpSAscLDGSLG-AsAIEIPP..NESLQARAARILGIEVAVESLLPGspRsGQsQsPEPDuSApssEuPREE.osuSsA.ss..sPososDAFYGRRKCGWTcSPLFV..GERDushRuP.AsE....pSsVDuslsSpsssPEPpPss.EspshppKDhts+PPFRSTLFHFIERTPoVuGSEKRLRSTSKVIESLQEKLASPPRRADsDRLMRMKEVSSVSRMRhLSsRSADSsEEAEELKA..RG.us.PtG.sohssuDhup+sGpssulSKGslSLEEsGHPAupR.EKs.scQDFWCP	.........................................................MaSVEDLLlSHGYt.....spp.s...s............th.........t..t....u.t...NGh..........................t..t.ssp......tt..................................thhpps..hhsup.s..tps.hh.hpR.ttp...u...t.p.t.tt....t.tthut.s.uhshp.......+Eu.h-VutpsEpVh..+pshhp-ph+hss.t+WQslshESWppP+clGRQMSDGsGE+hhp-....LYshh.u-pslsopsKtKSpSLPRsLSPESLphhElPhshs-ta......sKhs....as..Pspsssh-.ss+p.c.pssp.sPhP+PKFGRPLKPPS..Yp.pppoRussc....s..pDpp....phc...............sRp-hsh.D...s...G...LEPPVYVPPPSY+S..PPp.ph.ssPah..stsPh.hssspppQpp....hE+stsst......ssss.ususphssssp..P.uh..pP..p.ss.sasu.VQYIPFDDPRlRHhKlApstsh.hp-hchtcp.hss.us.ssst-sshtthp.cuAhhs.spshhs.sssp+u....ss..sss..SspWLhst..stss...Ess.uhPcQR-ps..ss.psp..Pss.psu..ptpstt.sos...sp..u-u.....o.CET.TKLKKFp..TG....hpoKK.SS...KKKhNETIFCLVSIPVKSESpL...PD.pDpNNNDLK............us-..ppsG.cp.s.suLQEQ.SLLShS..STDLELQALT.GSMus+schp+QshtcPctt+QssDLpFlc.sKHRELp.aSGSWPGcQYRDQQTQTSFsE-sposQ.hPus+.Gtss.sss.oPp.t.-s...............................ss.oc.sthpsuhsssD.pp+spu.slKGQhS.LSPSSNSAFSRTS.shsQuPhsKus.uQs............th.s.pt.sspPss..+tEVVKGEs.s.usCNSppLFGQFLLKPVSRRPWDlISQLESFNKELQEpEESpssu.....p.sssE....-u-tc...p..shs.st.cs.t..t.t.t.cht...thhs.-tPshpsGRhcspSpSWS.cc.p.s..t.ts.....hs....s..p.ttutu.sh..spush.s-...ptp.-..pthpp.shp.shPs.c.h..u....stps.s.....t.+.stt..c..t......ht.sp.ut.s.s.p.sth.ptts...h.LsLss+spGhStPDlpsltL..s.t.ts.p.....s.tsshEIPs..sESLQtRAsRILGIEVAVESLLPsstp.sttp..stsssssht.tsstpt....t...s.....th.tsua.uRRKCGWTcSsLFV..G-.......hs.t.......sthpt..ssp...PE.............ps.t.......sPh+uslh...phh-+ssss.ssEKRlRssSKVIEoLQtKLsSsPp+ss.-RLhRMKEVsSlSRMRhLS.+ss-S.--s-t.K.........................t............tt.t.................................................................................................................................................................................................................	0	1	7	15
+15205	PF15352	K1377		Susceptibility to monomelic amyotrophy	Coggill P	pcc	Jackhmmer:Q9P2H0	Family	This family of proteins is associated with a susceptibility to monomelic amyotrophy.	27.00	27.00	32.60	32.40	21.20	23.00	hmmbuild  -o /dev/null HMM SEED	982	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.99	0.70	-13.80	0.70	-6.61	18	67	2012-09-03 10:33:30	2012-09-03 11:33:30	1	3	37	0	32	60	0	648.90	38	85.13	NEW	QQRKQKFEEVTEKFQRAHlPhSQRRRu...Va....QKPVPPLEEALKQIQcSsLKSElNL.PsS+RPTlNWRsI...DsAL.PSuLS+N-a++Q+pLhS+l...sC-KEMpENs+ssLsos+.ssFQLKLEETQ+LLEDQ.HLSsLQ+Fp-E.VNQITNSETLSSIDSLEAGE...+.EEIYlTL.sKEs..SoSsQ.pNo.lSLcS...u.NlQSsN..hsCFDcDKLsaSKTQ.HINNWLpNLcspNTQosoPFoDILuKsNVL..PshEa....hNuKEQNs..sshspss-..RsTsTu.sNoluFV.pSPssFlpscKsE+sSEoSohpoTDu.oStsFK+E+PhVTESPsFKFSKAWsTPDSlTpEhsphSDQE+hSElTQcNRTTSl.TShlPhATPLlL.Po...........NpQSu.+sLsKsslH.lKEIcPlQ..CSDpLsELcDhKDE..+lKahssscccLP.LFSDshpsuhl...sp...Ns-scD.cKp+.hscTu.oL.SshhSNhDLVuQHKKhKaNIaERNGV+FLKSILKKESKYEHsYhKALllNpGhphGNQKAAAIRDSIELTK..cKGcsuEIsKT.IKKLRWFDEsuph.cpss--spSLKNpstlopQhSQ.hH..sp...SuAsSNlhSlPAsAlNSAsscpsK-............s.u.lS.csssslGtSspDpVPLNsF.lPSGYshAKQAW.sSK+EEu+sPV+.s.DSKsQKssPQRGtsKlIRRs+SAKVQSu.hlppsRK..GTllRPQSAS+AsshlQsQGKLllPHPPP+ssoN.RuuKshpsSp.CQsVhP.-sSQN.hhTp.ssh.NS+alLPsEaplNphsQESS.Pl.sssC.SDhVTVhPSLP.YsoSECpTlAK.lNaS.susQslApQDuolaCT.pRsPVhEEuh.oloL+sT-EEsssLWK+t+ssLsQN-+uADS.TVsRRKpIl...EN...KpRsLLEQKRQssGSlupKasEQhsNFup....oVpLSSSEPKQosRGTSsh.EEVS-STSpFLMAENLVKuSVPEDEILTshsSKQhpKssLsLNKTQph.NICALSAEEQKILQSLs+LNERLa	..........................QQR+p+hpEsTEpFQRAHlP.SQR+p.s...s.....p+ssP.LE-ALcQIptSs.lp..hsh...tp+shh...sh...cps...Sshsp.t....pt..t.....t.pc.hpEs.hhslsspp..hFp.pLcEhQphLccp.Hlsslpphpc-.lpphspSEoLSSlDSLEss-...p.pp.h.oh.s.p...u.shp..sp.h.hts.....p.p.tp...sh...h.ts.hthu+st...pph.hshts.sspss..ht-ll.K.s.......ph....hpspctps..s..pt.hp..t.hss..sst.s.s..p...h..shpt..tssp..th..st.............hst....p.s+s.sssp..s.th.....pt...p.p..pt......s..s.h..hhL.ss...........s......t...pt.h....thps....s.sthtph..hppt..php.hps.ttt....h.s..ps.............p..p.pt.....s..sh..t..st.s..tp.p..p.s.hc.pts+hl+uILKKcu+.c.s.h+slhhspth.htpp.stsl+DSlELsK.+t...E..+s..+KL+WhDEht........ph...t.t.tt..psh.t.......................p......ts...tp..t................h..p..........ttp....s.h.hssG.p.s+pAW.sst.tt.......ttsp..pt..pps..+hh+psts..s+sp.s..h.tpp+..ssh.p.QSspcsp...tsQu+h.hPpPP.ts...............................................t..h......ps.......s..s...s.....s....s......p......p.......ppt............tpt...............................s.....h.p......t....p.t.l.pQ++p.st.pht.+.....pph......sh......ss.p.Phps.ps..h.....tplS-STspFLhAEpLsptshsEscILshhpshp.tp..h..ppstp..sh.ssLShEEQ+lLpSLpcLNpRL.......................	0	5	9	16
+15206	PF15353	HECA		Headcase protein family homologue	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9UBI9	Family	HECA was characterised first in Drosophila where it regulates the proliferation and differentiation of cells during adult morphogenesis. In humans, HECA affects cell cycle progression and proliferation in head and neck cancer cells. It by slows down cell division of oral squamous cell carcinoma cells and may thereby act as a tumour-suppressor in head and neck cancers.   	27.00	27.00	31.10	31.10	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.34	0.72	-10.86	0.72	-4.34	14	102	2012-09-03 10:34:47	2012-09-03 11:34:47	1	4	77	0	66	93	0	102.00	54	20.64	NEW	hstCCsPhus..............p.tt.hphschpss.....+VhCsNEpCst.upaMH+pCF-tWEpslLs......hL+ohGRARSWS-+QRpQNLWTKKGYDLsaKhCuC+CG+GpL+KDh-Wh	......................................s..CssPhhs..............shhtslchpc.cDh.KVlCNNEpCPh..upaMHhpCF.cWEuolLs......phps.....hGRA.RSWsEKQpRQNhWTKKGYDLAF+hCSCRCGpGHLKKDhDW.h.......	0	17	22	45
+15207	PF15354	KAAG1		Kidney-associated antigen 1	Coggill P	pcc	Jackhmmer:Q9UBP8	Family	KAAG1, kidney-associated antigen 1, or RU2AS (RU2 antisense gene protein) has been found in mammals. It is expressed in testis and kidney, and, at lower levels, in urinary bladder and liver. It is expressed by a high proportion of tumours of various histologic origin, including melanomas, sarcomas and colorectal carcinomas.	27.00	27.00	88.30	88.30	25.00	19.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.12	0.72	-9.95	0.72	-3.65	2	9	2012-09-03 10:36:12	2012-09-03 11:36:12	1	1	9	0	3	2	0	79.60	84	100.00	NEW	MDDDAAPp.EGVPVAVHpHALH.tLRQVsGPGAuAsHLPRhsP.pLAAs.t.AP.LSQhPHRTpGAGSsPETNtp.TNPpV+EK	MDDDAAPR.EGVPVAVHKHALHDGLRQVAGPGAAAAHLPRWPPPQLAAsRREAPPLsQRPHRTQGAGSPPETNEKLTNPQVK....	0	1	1	1
+15208	PF15355	Chisel		Stretch-responsive small skeletal muscle X protein, Chisel	Coggill P	pcc	Jcakhmmer:Q9UHP9	Family	The murine X-linked gene Chisel (Csl/Smpx) is selectively expressed in cardiac and skeletal muscle cells. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway. Thus it is implicated in the maintenance of muscle integrity and in responses to biomechanical stress.	27.00	27.00	82.10	74.60	20.30	16.80	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.02	0.72	-3.97	9	43	2012-09-03 10:37:14	2012-09-03 11:37:14	1	1	39	0	28	31	0	84.40	77	98.29	NEW	MSKQPuSNV+ulQANINIPMGAFRPGAGpPPKRKEhTsEs.Eps.P...sstt.EEKK.lPGAhKLPGPAVNLSEIQNlKSELKaVPKAEp	.....MSKQPsSNVRAIQANINIPMGAFRPGAGQPPRRKEsTPEs...EE.u.s.P.....PTo-.EEKKPlPGAKKLPGPAVNLSEIQNlKSELKYVPKAEQ..	0	1	3	11
+15209	PF15356	SPR1		Psoriasis susceptibility locus 2	Coggill P	pcc	Jackhmmer:Q9UIG4	Family	SPR1 is psoriasis susceptibility locus 2 protein family.	27.00	27.00	123.90	123.70	18.30	17.60	hmmbuild  -o /dev/null HMM SEED	114	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.35	0.71	-11.10	0.71	-3.73	5	32	2012-09-03 10:38:06	2012-09-03 11:38:06	1	1	23	0	15	26	0	113.20	79	84.46	NEW	SpDHPSPPusEA+EEsuuPTLPQGPPIPGDPWPGAPPLFEDPPPPGPSRPWRDLPESGVWPPEPPoTDPPQPPLPDDPWPAGPQPPENPWPPAPElDHcPQcEPDLDPPREEYR	....StDHPS.sssEspEEtGSPTLPQGPPlPGDPWPGAPPLFEDPPPPGPSRPWRDLPEoG..VWPPEPPpTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDHtsQEEPDLDPPREEYR..	0	1	1	1
+15210	PF15357	SEEK1		Psoriasis susceptibility 1 candidate 1	Coggill P	pcc	Jackhmmer:Q9UIG5	Family	This family is considered a candidate for susceptibility to psoriasis.	27.00	27.00	28.40	32.70	21.70	20.90	hmmbuild  -o /dev/null HMM SEED	149	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.05	0.71	-10.95	0.71	-4.30	3	13	2012-09-03 10:38:49	2012-09-03 11:38:49	1	1	6	0	1	14	0	128.30	85	94.99	NEW	TDQKSHSQRALCTQTPALQGPQLLNTDPSSEETRPPHINPDRLCHMEPANHFWHAGDLQAMTSKEFHLAATQDDCRKsRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTsAPTLLYSPPPSHSPFGLSSLI	...TDQKSHSQRALsTQTPALQGPQLLNTDPSSEET+.P.l.PDRLCHMEPANHFWHAGDLQAMhSKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRT.APTLLYSsPPSHSPFGLSSLI............	0	1	1	1
+15211	PF15358	TSKS		Testis-specific serine kinase substrate	Coggill P	pcc	Jackhmmer:Q9UJT2	Family	TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ [1]. Recently it has been shown in human testis to be localised to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function [2]. TSKS is localised during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis [3].	27.00	27.00	87.10	87.00	20.60	20.50	hmmbuild  -o /dev/null HMM SEED	558	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.03	0.70	-12.87	0.70	-6.35	3	39	2012-09-03 10:39:39	2012-09-03 11:39:39	1	2	26	0	19	39	0	447.70	73	95.07	NEW	ESRopLuPEsPGusooPsKGhsKKKKAVSFHGVEPRMSHEPM+WCLNLKRSSACTNVSLLNLAAsEhsDSosp-oTTDD..PshsASGspSsPl...PPuuPo.sWAsDDPDIo-lLsGVNSGLLRAKDSITSLKEKTTRVNQHVQoLQSECSVLSENLERRRQEAEELEGYCoQLK...........ENCRKVTRSVEDAEIKTNVLKQNSALLEEKLRFLQRQLQDEsPRRQEuELQELEQ+L-AGlSRpsLuhousSouss.sPPsSE-cPsPP.........cuLulAthsupsRAGEGsEVS.pEhQKVoAGL......EELR.........REVSSLTARWaQEEGAVQEALRLLGGLGGRLDGFLGQWERAQREQAQAARGLQELRGRADELCTMVERSAVSVASLRuDLEGLGPVKPlLEELGRQLSSuRRGS-LSMsLDR..sGSCuRCuSQ.GQQLSTESLQQLLERALTPLVDEVKQRGLA.PACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKVAoLDYLHLKMCSLHDQLSsLPLEGSssohGGGSuGGAPPKRGGPsPEQ	................................SpsQLsPEsPtusos.sKGIsKKKKAVSFHGVEPpMSHpPMHWCLNLKRSSACTNVSLLNLA.Ah..Es.DSoGTDSTsED........SG.hsLss...PPuSPo.PWss-DsDIoElLSGVNSGLV.RAKDSITSLKEKToRVNQHVQoLQSECSVLSENLERRRQEAEELEGYC.QLK...........ENChKVTRSVEDAEIKTNVLKQNSALLE...........EKLRYLQQQLQDETPRRQEuELQE.E..............Q.K....EAGLSRpGLuPss.s.GCs.GPPGSP-cPsRP.........RuLsPuGWGMGsRAGEGPhlSEQ..ELQKV.sGl......E.ELR.........REVSSLTARWHQEEGAVQEALRLLGGLGGRlDGFLGQWERAQREQAQTARGLQELRGRADELCTMVERSAVSVASLRSELEGLGPlKPILEEhGRQhQsSRRGsDLSMNLDRu.QGsCuRCASQ.GpQLSTESLQQLL-RALTPLVDEVKQRGLs.PACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKhAsLDaLHLKhCSLHDpLSpLPLEGSTGoMGGGSuuGsPsKpGG.ssEQ.....	0	1	2	5
+15212	PF15359	CDV3		Carnitine deficiency-associated protein 3	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9UKY7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 251 amino acids in length. CDV3 is also known as TPP36 - tyrosine-phosphorylated protein 36. The function is not known.	27.00	27.00	30.90	30.00	25.60	25.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.82	0.71	-4.06	9	101	2012-09-03 10:40:36	2012-09-03 11:40:36	1	1	63	0	53	93	0	118.10	51	57.56	NEW	KE--EWKEFEQK.EVDYSGLRlQuhQh..sEKE--EsEK+--.t-shEEsGth........uuDKSSGPWNKSA.A.sPsAssh..VpEs.EP.spsuGVYRPPGARhTs.pRtssQGPPEIaSDTQFPSLQSTAKHVEoR	.............---EWKEaEpc.chDYSGL+lQshQI..s.EKE---s.EKc.p-.su-sh-EsGus.........Gs-Ku.S..G.PW.NK...........oA.s.......s...pAPsussh.......VsEsP.cP...sh..TuGV....YRPPGA......Rhos............sR+ss.........Q...G...P...PEIaSDTQFPSLpSTAKtl-oR..............................................	0	13	17	31
+15213	PF15360	Apelin		APJ endogenous ligand	Coggill P	pcc	Jackhmmer:Q9ULZ1	Family	Apelin is among the most potent stimulators of cardiac contractility known. The apelin-APJ signaling pathway is an important novel mediator of cardiovascular control [1]. Apelin is an adipokine secreted by adipocytes where it is co-expressed with apelin receptor (APJ) in adipocytes.  It suppresses adipogenesis through MAPK kinase/ERK dependent pathways and prevents lipid droplet fragmentation, thereby inhibiting basal lipolysis through AMP kinase dependent enhancement of perilipin expression. It also inhibits hormone-stimulated acute lipolysis through decreasing perilipin phosphorylation. Apelin induces a decrease of free fatty acid release via its dual inhibition on adipogenesis and lipolysis [2]. As a vaso-active and vascular cell growth-regulating peptide Apelin is a target of the BMP pathway, the TGF-beta/bone morphogenic protein (BMP) system - a major pathway for angiogenesis [3].	27.00	27.00	27.00	27.00	27.00	27.00	hmmbuild  -o /dev/null HMM SEED	55	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.76	0.72	-3.75	8	19	2012-09-03 10:41:47	2012-09-03 11:41:47	1	1	18	0	11	19	0	54.80	67	72.82	NEW	GPLhpssDGK-LEE.GolRpLVQP+suRsGsGsWQGGRRKFRRQRPRLSHKGPMPF	.GPLhpssDGpsLEE.GNlRaLVQPRsuRsGPGsWQGGRRKFRRQRPRLSHKGPMPF	0	1	2	3
+15214	PF15361	RIC3		Resistance to inhibitors of cholinesterase homologue 3	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q7Z5B4	Family	RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.	27.00	27.00	27.10	27.30	26.70	26.80	hmmbuild  -o /dev/null HMM SEED	152	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.10	0.71	-3.98	27	152	2012-09-03 12:43:49	2012-09-03 13:43:49	1	4	75	0	80	140	0	158.40	28	37.52	NEW	lVL.ClulllP+hh.....hsts....pp.....p..............hspssssphsPhhp........tts.ss..ss.t...ss..t.s+scshcuhspscsts.tt.ts.....supppuhhupllPlYuhGllLallYhlaKl.p.+scp..p.ppppps.............................s.t...........pss.........t...+pc..hs-hcLspLQ-RLppTEchMppIlo	.......................................................................................hhs.............................h..hths...P.hhc...........................pts.ss...ss.s..sthh.tRst.h.uht.shGuu.stt.ts............tsptpuhhG..lhP...l...YshGIllahlYhLhKl..ptKp..s.pc.ttss..............................................................................................tt.............tp...........hcpt...sphcLtpLpp+LppTEptMppll.s................................................................................................................	0	16	26	50
+15215	PF15362	Enamelin		Enamelin	Coggill P	pcc	Jackhmmer:Q9NRM1	Family	ENAMELIN is involved in the mineralisation and structural organisation of enamel. It is necessary for the extension of enamel during the secretory stage of dental enamel formation. The proteins are expressed in teeth, particularly in odontoblasts, ameloblasts and cementoblasts.	27.00	27.00	34.50	34.50	16.30	16.20	hmmbuild  -o /dev/null HMM SEED	906	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.82	0.70	-13.77	0.70	-6.46	36	250	2012-09-03 12:45:25	2012-09-03 13:45:25	1	2	199	0	21	246	0	720.00	60	93.29	NEW	PYYSEEMFEQDFEKPK.EcDPPKsESPs.TEPouNSTVsETNSTQP...s...sGGSQGGNDTSPTGNss.G.NsGsNPssQNGlhssPsVNlSG...QulPRSQIPWtPsQPNIaENYPNPN...lRsFPsGRQWpPTGTshGpRQsGPFYRN.psQRGspWNSFAhEuKQsA+PGNPsY+KsYssToRuN...PNaAGNPANFRRKPQGPNKpshGTNls...PluPKp.GTls+sEKlQNP+EKsl.GQKERhVhPT+DPoGsWRNSQsYG.lN.KsNYKL..PpPEGNh.lPNFNSlDQ+ENSYYPRGDSRRsPsSsuQsQoQNh.PKGIsLEPRRIPYEoETspPELKHuTapP.hYPEEIPSPsREaFPsGRNTWNcQEISPsFKEDPt+QEcpLPa......PShGSRGsVaYsEYNPYsPR....ENSPYhRSNTWDERsDSPNTh...GQPcNP.Y.PhN...TP.D.QK-TlsYNEEDPlDPT.GDE.FPGQs+WG.E.E.suFKtuPTVRaY.EGpQYs...S...NQP...KEYLPYSlD.NPsKPREDhPYuEFYPWsPDEsFPSYNsuPTloPPsEsRGYYs.NNAltQEESolFPSWNSWDa+IpsQuQKE+pPYFNRNaWDQuTNLHKsssssPsQKENpPYSSNsPAGLQKNPTWpEG.EN.LNYsM.QITRLNSP-+-HLuFsDllPQsYPssQcEsaLFH..SQRusCCAGuSsG.+D.NPLALQDYTPSaGLsPGEsp-osPhYTEuSHTKHARalISPTSILPuQ..RNSSEK+L..PGESQs..P..FRDDVSTL++NTPCSl+sQlGQtGhh.sFPEAuSLQSKNTPCLKuDLuGDGNN.lLEQIFEuNQ.lNERTl.sLTPEQLlIsTP-EuPKPEuIQSEl.QGsEGE+QQpR.PPSILQlPCFGS+LsKa+sSSTGTPSopGRpGsaDGDssMPTEpP.sTLsGLATGEQFpulNVD.LNA	...........................................................................PYYSEEMFE.QDFEKPK.EcDPPKsESPs.....o-PosNoT..ssETNSTQs...s...stGuQGGNDTSP....TGsss...u.NsssNsssQNGl.s.PsVNsSG...QssPto.QlPh......t..PuQPNIaEN.aPNPN...hRsFPsGRQWp...............TGo.shGpRp..suPFYRN...........sQRu..pWNoaAhpuKQs.s+PGNPhY+KsYsss.uRuN.....PNaAGNPuNhR...R...KPQuPNKpPh.sTNs.u...sh.uPKp.s.T.ss+sEplQNP+EKsh.uQKERhlhPT+..sPousWRNSQpYt.sN.K............sNYKL..P.PEush.sPsFNSlDQ+ENSYYPRsDS..R+sPsSssQhQsQNh.PKGlhLcP+RhPaEoEsp..pPElKHuoap.P.s..............Y.......sEthPsss+EpFPs.G+NTWNpQE..ISPsFKEDPGRQEEpLPH......PS.hGSRGsVaYP-...YN.PYsPR....ENSPYhRuN.oW-ER.sDSPNTh...tQscsPhY.PhN...TP.D..KcTlsYNEEDPlDPT.GDE.FPGQsRWG.-E..SFKt..sPTVRaY.EG.cQYs...S............NQP...KE...YLPYSLD.NPsKPRED.FPYuEFYPWsPDEsFPSYNsuPThs.PPsEspGYYh.ssA.htp.E.Eus.h.PSWsSWDp+hpspspcEptP.YasRNhWspsspLpKs.sp.spQ+cNpPYsss.PsG...LQ+NPhWpEu.Es.LNYsh.QhsRlNsP-tpp.sF..-hls.sYPssQpEuphFH..SQRusCCsGushG.+-.s..PLALQDYTPuaGLsssEst-ssPhYo-sSHoKasR.hlSPsuh.ssQ..RNSSEKp......tEsts..P..FRDDsuoL++ssPCShps....plsQhthh.shsEssS.Qs+NhPCL+sDLuGDGss.lLcplF-ssQ.hsERTs.sLsPEQLlh...ssP-EsspPEsIpsEh.ttpEschpQpR.sssIhplPCFsSplsphhsSosGsPsu.uR.sshst-.h..hPTc.P.sohstLATttphpshNlD.ls.......................................................	0	1	1	6
+15216	PF15363	DUF4596		Domain of unknown function (DUF4596)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9UPP5	Family	This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.	27.00	27.00	37.00	37.00	25.90	18.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.96	0.72	-8.28	0.72	-4.04	10	87	2012-09-03 12:47:34	2012-09-03 13:47:34	1	3	38	0	49	63	0	45.80	71	4.71	NEW	-ThuRWuELhSPLDDSosSl.T.VoSFSP.ED.ssSPQGEWTIlELETaH	...pLuRWuELhSPLD-SpASI.T.VsSFSs.-D.suSPQG-WTllElET.H	0	3	8	19
+15217	PF15364	PAXIP1_C		PAXIP1-associated-protein-1 C term PTIP binding protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BTK6	Family	This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localise at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length [1].	27.00	27.00	42.40	42.00	24.70	24.00	hmmbuild  -o /dev/null HMM SEED	141	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.17	0.71	-4.27	21	81	2012-09-03 13:14:09	2012-09-03 14:14:09	1	1	71	0	53	71	0	129.70	44	61.23	NEW	-WplssSD-Eh......................sW.PsPpEItcL...Ychl...spstsLELpaps.sRRs....PoPp.tsp..csppsp....pttctt.-pcs.ps.oEFDF.DD-.s..p............sphhsRRpssuo..ttSspK+pAphDcVLscM+RH+..........+l.ppthpps	....................-WslsCSD-Eht.s......p..................sWhPsPpEIpcL...YEhL...sspssLELQhchhsRRs....PoPEspsptpcs-c......cscEpt.Ec+PphP.oEFDFDDE..s.osp..........sshhsRRRTPGo..ss+Sp.KRpA+hDKVLSDMKRH+..........+l.pppI...hcp.........	0	16	20	35
+15218	PF15365	PNRC		Proline-rich nuclear receptor coactivator	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NPJ4	Family	The PNRC family, proline-rich nuclear receptor coactivator, is found in eukaryotes, and is approximately 60 amino acids in length. There is a conserved YAG sequence motif.	27.00	27.00	27.10	27.10	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	58	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.43	0.72	-9.06	0.72	-3.96	36	209	2012-09-03 13:16:56	2012-09-03 14:16:56	1	1	132	0	140	210	0	56.20	38	22.51	NEW	ssssYAGu+FopsPsPosLPhPP.cWhtsss....................p..shpthop.............pL+tlL.clp	....t.tppYAGup.F.us.sPuPSsLPhPs.ahhsss..............................................t.stp.hs.........................................pL+tlL.pl.......................................................	0	27	56	92
+15219	PF15366	DUF4597		Domain of unknown function (DUF4597)	Coggill P	pcc	Jackhmmer:Q96GX8	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 63 and 76 amino acids in length. There is a conserved TPPTPT sequence motif.	26.50	26.50	27.60	82.30	25.30	18.10	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.76	0.72	-9.15	0.72	-4.39	4	25	2012-09-03 13:30:01	2012-09-03 14:30:01	1	1	22	0	15	24	0	61.10	81	62.28	NEW	MCVSS.suSp-EAPVLsDKHLDVPsIIITPPTPTGMs.lPRDSp+sVWhDEsGShsDDGElDsE	MCVSSsSSSHDEAPVLsDKHLDVPsIIITPPTPTGMM.LPRDSppTVWLDETGSCPDDGElDPE..	0	1	1	2
+15220	PF15367	CABS1		Calcium-binding and spermatid-specific protein 1	Coggill P	pcc	Jackhmmer:Q96KC9	Family	CABS1 is a family of proteins found in eukaryotes. It is also known as NYD-SP26. It binds calcium and is specifically expressed in the elongate spermatids and then localised into the principal piece of flagella of matured spermatozoa.	27.00	27.00	50.90	50.90	18.90	18.50	hmmbuild  -o /dev/null HMM SEED	396	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.29	0.70	-5.60	9	23	2012-09-03 14:10:36	2012-09-03 15:10:36	1	1	20	0	11	26	0	382.60	67	87.66	NEW	MAEDG.PKIYSHPPTESSKTsTEATIFFGADNTIPKSETTITSEGDHITSVNDahhEuDFSTTssNKLTssKE+lKSEDDlEu.hlKSoThhEKEITTLTuTsNShAs-SITENFIPVKIGNISSPVATVSLIDFSTNhAKEDILLsTlDsGDc-Vs.hTSElSGol+-STsslsDTPsLPscpscsDs...sSSsKSsssADtsVQlTDS.lPEAEIsPoTE+NlTTIPDITslTEEKITEIDLIlsEDDPssVsKLTDSDEEKFITVFELTsoAE+DKDNPEDh.LsDEESTDElNVWMER-pssEAEoHsVLLTAVESRYDFlVPsSlAhNlpE-Ss..T..c..EDLsENspsESVTKsTEshS....tsTs..Ds.spcEDs.TTEoGlFKLLKE-PDEFhI	.MAEDGLPKIYSHPPTE.SSKTPTtATIFFGADNsIPKSETTITSEGDHVTSVN-YhLESDFSTTTsN..............KLTssKEKLKSEDDhtochIKSTT.HLpKEIToLTGTsNShs+DSI...TENFhPVKIGNISSPVsTVSLIDFSTsIAKEDILLsTIDoGDtEls.ITSEVSGTLKDSoAulADoPAhPccKDEuDhsNYsSSlKSNVPADEAVQVTDShIPEAEIPPusEcsFTTIPDITALpEEKITEIDLsV.EDDssAVupLTDSDEEKFITVFELTTSAEKDKDN.EDTLLTDEEST-GANlWMER-oANEAETHSVLLTAVESRYDFVVPASlATNL.sE-SST-..EDLSEs-pTEoVsKlTEPFS....uTTSlLDTPsaKEDTSTTETsIFcLLKEEPDEFMI..........	0	1	1	2
+15221	PF15368	BioT2		Spermatogenesis family BioT2	Coggill P	pcc	Jackhmmer:Q96M83	Family	BioT2 is a family of eukaryotic proteins expressed only in the testes. BioT2 is found abundantly in five types of murine cancer cell lines, suggesting it plays a role in testes development as well as tumourigenesis [1,2,3].	27.00	23.80	57.00	23.80	24.70	19.30	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.08	0.71	-4.49	9	46	2012-09-03 14:16:37	2012-09-03 15:16:37	1	2	17	0	13	36	0	153.80	67	46.74	NEW	MKsuKa.hsoSsKl.ssVPELs.KKGlh.s.shSscsKEK+SuKll+sKlEPMVLRS.PPTGESllRYALPIPSSKT+-llucDEhl++IT++LKMlVSTLE-TYGhs..hpsGEcshsKsEpE-h...sLSVGDDlsSFLhpCSphAuQLEEAVKEEcsILESL..FKWFQtQVNQMEE	...MKPsKHLLToSsK..ssVPtLshKKGLh.N.PlSPchKEKHNAKLl+DKIEPMVLRS.PPTGESIVRYALPIPSSKTKsLlsc-EMItKIhKHLKMVVSTLEETYGtC..spNGEcshlKpEpEEL.........oLSlGDDhsSFLhhCSQFAuQLEEAlKEEpN.....ILESL.....a.KWFQhQVNQMEE............	0	1	1	1
+15222	PF15369	KIAA1328		Uncharacterised protein KIAA1328	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q86T90	Family	This function of this protein family remains uncharacterised. This family of proteins is found in eukaryotes.	27.00	27.00	28.00	28.00	23.80	23.20	hmmbuild  -o /dev/null HMM SEED	328	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.58	0.70	-12.40	0.70	-4.62	8	73	2012-09-03 14:28:52	2012-09-03 15:28:52	1	4	37	0	31	57	0	214.80	46	55.11	NEW	DLCPEDKRRIANLIKELARVSEEKEVTEERLKsEQESFEKKIRQLEEQN-LIIKEREALQ...QYRECQELLSLYQKYLSEQQEKLohSLucLuAA+tpEQplSu+KSshpsus.c.....LDGSYLulAtspshhpsp++sKuuspupuupohsshpNs.sh+sphhppPp-shcc.P.Es...RoCssctssh+.tsst.hcp.....h...-.+hpEh.shpPsssocsCuH+putsuspl+-upasophu.ppstophcoCsasphshsS.hptpsh.ts.ETpluKplSE-RRQQLLLQKMELEIEKERLQpLLAQQEsKLLLKQQQL.HQSRLDYN	........................................sRlscEKE...pch+sEppphE..lp.Lcppp.hh.pE+..h............................................tts...pp..osccs..pps..p.....LDGSYLulutst.h...ptt.pss..s.ss.s...hpNp.s.p...h..spcthtc.s.cs...tsss.t.sshc...s..hc..........-hphpEh.phpss.p.psCu.c+hu..ss.spps.pstphs.phstop.coCsasthshsS.hpstsh.ts.Ep..t+p..E-++ppLhhQKhpLEhE+E+LQthLspQEtKLLhppQQL.pQSphpYs..............	0	5	9	15
+15223	PF15370	DUF4598		Domain of unknown function (DUF4598)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N5I9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 159 and 251 amino acids in length.	27.00	27.00	27.60	27.20	24.80	24.80	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.51	0.71	-3.78	7	138	2012-09-03 14:34:31	2012-09-03 15:34:31	1	2	125	0	98	135	0	109.00	27	54.16	NEW	sLLSRLSAFLPpMKsAN--LpREItAGR..uKDlpLD-lD-.p-GQ....YIEMNLGLGVLEEKR....ssDssusstp.scupc......s.stpts...pDSslL-+LhGp+csossp.......KPoIpEhs	...........................lLs+lpsFLPphtpAN-cLccchss.us..stchsI..E..sl--..scsp......................hIEM............sluLG.lh-p..pp...............stcs.ppssp.spp.sspc............ts.tppp.p.ttpt...........................................t...........................................................................	0	32	44	69
+15224	PF15371	DUF4599		Domain of unknown function (DUF4599)	Coggill P	pcc	Jackhmmer:A6NFA0	Family	The function of this family of eukaryotic proteins is not known.	27.00	27.00	28.70	28.10	25.00	25.40	hmmbuild  -o /dev/null HMM SEED	88	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.32	0.72	-10.12	0.72	-3.92	56	185	2012-09-03 14:35:58	2012-09-03 15:35:58	1	4	23	0	114	144	0	88.00	33	9.50	NEW	tRs+pRp+s...ssh+u....pR..p..spcEsE.cspcLlSlLcS.h.u...........hLspc...s...shRpLLCsDPsCpVCNssssElp.....pLLhtEshp.s.uss.ss.usssu.sus	...........................t+s+pRt+s...ts.+u....pR..pspcEhE.ch.......pcLlSlLpS.h.G...........hspcu...sh+pLLCsDPssclCpsssschp.....phh.tEshp.s.uss.sluPhsusss.......................	0	15	15	15
+15225	PF15372	DUF4600		Domain of unknown function (DUF4600)	Coggill P	pcc	jackhmmer:A6NNP5	Family	\N	27.00	27.00	29.60	29.60	26.40	26.40	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.88	0.71	-10.74	0.71	-3.93	11	65	2012-09-03 14:38:42	2012-09-03 15:38:42	1	3	40	0	35	65	0	99.30	45	50.06	NEW	cEuNEWKTRYETQhElNcQLE+QIhhL+c+lEph+s.NspD..+hu....SlRs............h-ph..ospuLpphlKpLE+EKptLpsQL+-hEhRL-QEuKAY+Kss-ER+tYlsElspsp.ss.php++Qphs...thpcsscs.scs	.......s-hphpYcs.hEhNppLpcph..hppphpph+u.sspD.ths....sl+s............h-pM..ss..-SLNpLLKQLEcEK+sL-sQlK.hth+LEQEuKAYpKhssER+sYLuEhopsS.s..phs++Qphsth.chpEp...s..............	0	9	11	15
+15226	PF15373	DUF4601		Domain of unknown function (DUF4601)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NA69	Family	This protein family is a domain of unknown function, which is found in eukaryotes. In humans, the gene encoding this protein is found in the position, chromosome 19 open reading frame 45.	27.00	27.00	31.60	27.50	26.20	26.30	hmmbuild  -o /dev/null HMM SEED	440	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.82	0.70	-12.46	0.70	-5.62	11	46	2012-09-03 14:42:42	2012-09-03 15:42:42	1	2	32	0	25	42	0	319.10	42	85.36	NEW	LFppDsRWsupE+VSEs+RAF..PPPs..shp..pEpsRERohAhQuSsL+lHADuRstssLSoARusYGWPElPs+A+EpIRGARLlFDRDSlPsGDR-KLRIPsTTaQshFPP+DA.sPQPRAPspHL.GGPNsL+W-YcpQ.-sTSYQ+QFQALPuPPALMCKRASSSVcLGDsKIGYuPhCSEQKpAYpPQsLPPD..RYDKAQAuAHIHpVNIpPGDuLF+DRTTpu-HFYu+EP.EPFVLHHDpTPESHILcGNWsPG.PGSLsTShphFYG.QPsPsTpPPuRHlsH-pLQSHl.sLG-PcLLGpFFQToMuoDYsPs....phs.......p.p+AsNL+LhpSpLPpsouEhDFLToN.QpMlKPHphssASsTEEhLQRCKYSHlEPPLGpQRFFSTQYcDEFPaKYQGPsVL+.hushQESHVPLGTs+phGChtcKlDPpAPQhPhYPCPSQ	..........................................s.....a..................t.......sphph.ts.p.t...o.hp.t..h.t...t.....ttst.hatpDohPsGD+p+lchP.osaptha.sa-h..psts.+sPshHh.uGs.sslphs.hptp......tToYpppFp..uh.usPAh....p.+ch.t..Spl..hGD.phsht..so..pphhts.t..s.t..R.Ys+tpAsu+lp.ss..ltsGDshh..c.p..TThscpFh.spcs.-Phhlc+c.ppstSpIhcGshsPG...suu...ls....T...hphFau.psss.s.......spPsscclspc+Lp..SHV.pLG-scLhtpFFpTohsoDYhss....ph...........p.p+s..sshph..Stl..s..ssp.salThs.pthh.hPH.t..h..t..hoc-hlQ+s+hSHh.sPhst.+aFSTpap-pas.K.Y.uPhs.p..tp.Qcu.lPlGo.t.............................................	0	5	7	11
+15227	PF15374	CCDC71L		Coiled-coil domain-containing protein 71L	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8N9Z2	Family	The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.	30.00	30.00	30.40	32.10	27.60	29.80	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.17	0.70	-5.14	18	76	2012-09-03 14:45:56	2012-09-03 15:45:56	1	2	35	0	40	87	0	232.80	33	89.74	NEW	sEEKAVHSWSR..ISoAGpKALEEAL+VFNPMSpDLosTEsQLVAFLQGLR--GFQPTILRSKDVYGYSSCTAssPSQTKhpspssssss..sSsPs+ssppuhthssu+ustlshslssp.uKsustslsK.tsoTNLLLsSLKQopuspupssshuFPsphYPGVYPAMRLSVVLEALVP..LKssssCLpuKh......pphtLulusSslKLhKssu.s..ps..Ks.......hpsKu.pplhp+ust..............GPptsshppSpssKuoG.LsGhhhpsuSphssptspspt......................................................................................+spt.s.sphsh+stpsp.EshG.pKRK+s-EsK-hss+K+s+.hP....s.K.....splspuThsLL+FpsIKVs+....psSDDEVRp+AQ+ILRVNLSPVIRlQPL	.........................t+sVhuhup....ssuppsht-AhhlF.PhSp-h.so-tphhsFlptL+cp.hpPhlLpStDVYGYsSsps....................................................................................................................................................................................................................................................................................................................................t....hh..t............................h.tt.........t..........us..phhph.sI+Vst....p.S.stsRppApplLpVNLpPhlplp.h.............	0	3	5	10
+15228	PF15375	DUF4602		Domain of unknown function (DUF4602)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8NDD1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 173 and 294 amino acids in length. This family includes Human C1orf131.	27.00	27.00	27.00	27.00	26.60	26.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.55	0.71	-4.10	42	158	2012-09-03 14:46:48	2012-09-03 15:46:48	1	3	126	0	111	162	0	137.30	22	56.05	NEW	VsFps.p..........p+cpp.........................p.stspspst.t...t..tp...................ptp.tpchslc+.s.......+h-VpcFGhouapt.cp++phctppslpLGAKsP.KpphlNYKhlhpppKppKtcccc.ctphtptsshhptppp......tpppppc+ppcpcsss	.....................................................................................................................................................t.tt.pptpt..t.t........t.................................ptpppchslcK.s.........+hEVccFuhos.h..st.tc++phEpccsltLGAKPs..KpphlNYKhLppphKcpKttccc.ccch..tptss..hhppppp..........ptpcpppp.ppp.....t........................	0	43	58	85
+15229	PF15376	DUF4603		Domain of unknown function (DUF4603)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q92628	Family	This protein family is a domain of unknown function. In particular, this domain lies at the C-terminal end of a protein found in eukaryotes.	27.00	27.00	39.70	38.70	19.00	19.00	hmmbuild  -o /dev/null HMM SEED	1286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.37	0.70	-14.36	0.70	-7.37	11	83	2012-09-03 14:47:49	2012-09-03 15:47:49	1	3	49	0	49	72	0	742.60	54	88.25	NEW	GPlSsSEMSLL+ALGPVQTWLGQELEKCGIDAMIYTRYVLSLLLHDSYDYDLQEQ..ENDIFLGWEKGuhKKWGKSKKKC.oDLoLEEMKKQAAVQCLRSASDESSGIETLVEELCS+LKDLQSKQc.EK..IpKKhEGS.SPEs-.SPoAKDQVEMYYEAFPPLSEKPVCLQEIMTVWNKuKlCSYSSSSSSSTAP.TSTDTSSPKDCNSEuEssKERsspA.s...ssspE+uQ.pRSKpEKEN+hssuss...EEK.sshhKKQsRH+SEGKhRPRSWSSGSSEAGSSSSGNQGEhKsu.hKhVKVRHKsREs.RNKKG.RuGQsRhshKss-KsER+stuG.....sSuSuuuGul+.QLCKRGKRPLKEltRK-uGspEuK-lhsEu+s-KEYKEEPLWYTEPIsEYFVPLS.RKSKLETTYRs+p-ssshs..SEAVE-LSEuV+GLCISNsNlH+TYLAAGTFIDGHFVEMPA.VlsEsh-LsGTShCS.PEDspaLDDlHLSELTHFYEVDIDQSMLDPGAS-shQGESRILNMIRQKSKEcsDFEAECCIVLDGhELQGESAIWoDSsSSlGAEGhFlQ.DLuNLAQFWECCSSSSSsDADGESFGGDSPlRLSPlLDSThhsschLAGNQE..LFSDssEGS.GlNSs.FSVFEVQCSNSVLPFoFEoLNLGsEN.TDSsSosNhLGKTQSRLLIWTKNSAF-ENEHCSNLSTRTCSPWSHSEETRSDNETlNlpaEESoQFsuEDINYVVPRVSusYlDEElLDFLQ--oCQQppcoLGEhPo..LlFpKKSKLESVCGIQLEQKsEsKsaETsps.sssuS.pGDsYSSGVIKDIWTshuDRsSsAsl-s-ch-..-cLFSsDVNsY.CCCLDsEAKhEslQ-.spKAVQRSEYHLWEGQKtshEKRAFlss-LSKVDG.GDYTTPSKPW-lspDKE.sSFILGGVYGELKTFuSDGEWAVVPPucs+GSLLQCAA.......SDVVTIAGTDVFMTPGNSFAPGHR.LW+PhVSFEQuEQs.KuG-sGLNKGFSFIFHEDLLGuCGNFQsEEPGLEYsFSSFDLsNPFSQVLHVECSFEPEGIASFSPuFKPKSILCSDS-sEVFHPRICGl-RTQYRAIRISPRTHFRPISASELSPGGGSESEhESEK-EuSlPlsSQsDVF-DPQADLKPLEEDAE+EGHYYGKSELESGKFLPRLKKSGMEKSAQTSLDSQE-SuGlLPhscQs.CL-Cshp-olpss.hESScusCKlhpppppEhschCSCcsuCphPshp-s..luust.hpEFPlLNsDlQshstuQpcpsWWpKALaSPLFPuSpC	...............hsss-MS.LpuLGPVQoWLGQELEKCGIDAMIYTRYVLSLLL+DSYDYD..L..p-Q..EpsI.LGhtc.......Gsh++.hs...+u++..Ks...shs..hE-...hKKQAAVQCLpSASD-sS......GIEoLVEELCs+LKDlQ...scQ........c...EK...hp+K.-tu.sP.Eht..S.ss+...DpsEMYY-AFPsLspp.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	8	10	24
+15230	PF15377	DUF4604		Domain of unknown function (DUF4604)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96AT1	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 141 and 174 amino acids in length and contain a conserved LSF sequence motif.	27.00	27.00	28.70	28.10	23.50	23.30	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.42	0.71	-4.02	68	196	2012-09-03 14:49:01	2012-09-03 15:49:01	1	3	171	0	140	196	0	148.90	26	88.71	NEW	ppsloYsc..sEPsFLp+h+.sphGhppss..................s+cpth......................sscscss.s.-..cp.....D-tPpVVllc.ss.-Lot.-Ehpthhpt...........................ttppppptsstsuclha+ps................pKRpsscthssts.......................t.ttt..............tt.tp+ppp+pp+..tpshLSFs---	..............................tpsloYsc..sEPuFLp+h+.pphGhppss.....................spcp.h........................sscscsss.-.......cc.........D-tPpVVshc.ps..cLot..EEhpthhpp..............................................................tttptppp...ssssuclhh+ps..........................................tKRps..schh...ss.s......................................ttt.t.............ppp.ptp+pppKphK..p..LSFs---.......................................	0	42	66	108
+15231	PF15378	DUF4605		Domain of unknown function (DUF4605)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96D05	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 82 and 137 amino acids in length.	27.00	27.00	27.30	27.00	24.40	26.90	hmmbuild  -o /dev/null HMM SEED	60	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.60	0.72	-8.63	0.72	-4.27	13	84	2012-09-03 14:50:09	2012-09-03 15:50:09	1	2	46	0	54	67	0	59.00	54	46.72	NEW	olFuplNcpLlshGFPphphGs+lVEPlsslhhhhlLhhlGlpGLLLVGllhlVhhhs.Qc	...o.Fu-LN+pLlNMGFsphahGp+lVEPVhsIhhhhhLhhLGlpuLhLVullhLV.hhsQp....	0	8	11	25
+15232	PF15379	DUF4606		Domain of unknown function (DUF4606)	Coggill P	pcc	Jackhmmer:Q96LL4	Family	This domain family is found in eukaryotes, and is approximately 100 amino acids in length.	27.00	27.00	31.90	31.50	22.10	19.40	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.35	0.72	-3.96	13	38	2012-09-03 14:51:17	2012-09-03 15:51:17	1	1	33	0	26	26	0	100.60	56	38.32	NEW	CsVPcELlNRIahKNhRsslKQsusu+pHlsSQCPsCN+KRAELAQusFLRpKKTLLEShLLpEKIDEHLaTKDhLThIGEAHpuLPRLSDDP+IIWKRLsEKu	...........................CTVPDELlNRIYhKNhRso.KQhusAKQHlSSpCPsCN+KRAELApuAFL+pKKTLLEShLLQEKIDEHLaT+DFLThIGEAHp.s.hPRLSDDPRhIW+RLspK......	0	5	6	9
+15233	PF15380	DUF4607		Domain of unknown function (DUF4607)	Coggill P	pcc	Jackhmmer:Q96LP6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 207 and 359 amino acids in length.	21.00	21.00	95.20	95.10	20.40	19.10	hmmbuild  -o /dev/null HMM SEED	265	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.93	0.70	-11.82	0.70	-4.94	4	19	2012-09-03 14:52:14	2012-09-03 15:52:14	1	1	13	0	6	20	0	243.90	63	81.77	NEW	hAhKRLL.sTpQhllPRs.sVSTsSF---SYtEhtspPsPSSEhDEsPhhFTsctEhp+csRtsP+QAWSSshLEQ.hst+PshsHSVNPlHLEAtGhHIpRHsRPpsQPLsssKtsSGSsARPaTAIGLCRRSQTPhA.QSsu.SsoE.E.EERhAAPAGu.AHPD.lQSRLLGAoGssVs+GAVAMAPEMLPKHPHsPccRRPRADoSLHGNLAGAPLPLLAGASTHFPSKRLIKVCSSAPPRPoRtFHTVCSQALSRPVVNAHLH	......huhKRLL.pTCQYIVPRS.oVSTsShDEE..ShtEhpSSPuPSSETDEAPLIFTAcGEsEcRARGsPKQAWsSSFLEQ.hspKP.shs+SVNPlHLEAtGIHIsRHTRPKuQPLSssKpNSGSuARPhTAIGLCRRSQTPsA.QSsusSsoEhE.EERhA.sPAGu.AHPD.lQScLLGASGNPVGRGAVAMA.PEMLPKHPHsPccRRPpADoSLHGN.....LAGAPLPLLAGASTHFPSKRLIKVCSSAPPRPoRRFHTVCSQALSRPVVNAHLH..	1	1	1	1
+15234	PF15381	DUF4608		Domain of unknown function (DUF4608)	Coggill P	pcc	Jackhmmer:Q96MR7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 85 and 157 amino acids in length.	25.00	25.00	26.90	116.20	22.20	16.90	hmmbuild  -o /dev/null HMM SEED	75	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.57	0.72	-3.84	3	10	2012-09-03 14:53:25	2012-09-03 15:53:25	1	1	8	0	2	4	0	72.90	90	60.65	NEW	SSAETLRTVSRRSVPSSSMPYLALAHSRVSSLNHAASVDGsuTSHRNVADSFSRTSRSCSRFLKGTAGSAGR-Gs	SSAETLRTVRRRSVPSSSMPYLALAHNRVSSLNHAASVDGWGTSHRNVADSFSRTSRSCSRFLKGTAGSARR-..s..	0	1	1	1
+15235	PF15382	DUF4609		Domain of unknown function (DUF4609)	Coggill P	pcc	Jackhmmer:Q96N06	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 70 and 139 amino acids in length.	27.00	27.00	122.40	122.30	19.60	17.90	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-9.32	0.72	-4.27	7	23	2012-09-03 14:54:21	2012-09-03 15:54:21	1	1	18	0	10	23	0	69.40	74	58.25	NEW	EKPDsKtKSSKKKsVIPQIIITRASsETLlShuS.sS-EQRTI+EpADWGPYtRHRNPSTssAYssQs+E	.EKPDVKQKSS+KKsVVPQIIITRASNETLlSsSSoGSDpQRTIREpcDWGPYtRHRNPSTsDAYssHhKE..	0	1	1	2
+15236	PF15383	TMEM237		Transmembrane protein 237	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q96Q45	Family	This protein family is found in eukaryotes. The function of this protein is to aid the production of new cilia in ciliogenesis. Mutations in the protein cause a disease, named Joubert syndrome type 14 (JBTS14) and also affect cell signalling using the Wnt pathway[1]. Proteins in this family are typically between 203 and 512 amino acids in length. There are two completely conserved G residues that may be functionally important.	27.00	27.00	27.50	31.90	25.50	26.90	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.54	0.70	-5.25	22	115	2012-09-03 14:55:22	2012-09-03 15:55:22	1	7	77	0	76	122	0	207.20	32	51.64	NEW	sstpt.sscltscs-Dhhs..........-.t....pp.s.hsssph.SQP............ss+laVE+s..pcFpssc+schh+spp.h........cshh-.csh....aooh-lAlplacuF+hlulasHGFLAGaAlhphlllasLsupphst..............sLLppYphLAhPhpulhYhLLslSoVSAFD.............Rl-lu+sshs...lRshlplsssuLs.hlYFsuLlloLSpphhs-+lshh......s.ssshasssscpp...........llpsWhhlNllhAlLsuLuWlhluhpPspDhs	.....................................................t.................................................s.P.........................splalpts..ttFpthc.......hpt......................p...c.c......hoshclAhsVp+sa+hluh....hsHGhLAGhAlhpllhlasLsspphstl.................................................................sLLppYpslAhPhpshhYhLhsluhlSsFD.........................Rh-hu+hohu...hpth.ls.hcsssls.h....lYhssllLolspp.hs-+ltLh.................ss.N.olh..thtpp.............llpsWhslslshulhshhuWlhluhpPt.Dh....................	0	19	27	53
+15237	PF15384	DUF4610		Domain of unknown function (DUF4610)	Coggill P	pcc	Jackhmmer:Q9BUH6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 164 and 206 amino acids in length. There is a conserved NPG sequence motif.	25.00	25.00	30.50	59.20	22.60	23.10	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-11.30	0.71	-4.78	6	40	2012-09-03 14:56:59	2012-09-03 15:56:59	1	2	28	0	21	47	0	176.00	56	94.80	NEW	ssLCTLs.sGsspPRaVCYCEspputt..stGlFNltlTsus-lWSTphos-SLuphKu+FGLsuTEDhssRFRsACpQQsVuloLQED..pAsLpLuGsPSsLoF-LSKlPssEAtPRLpALhLpLA-+VpsLEpRLAssEpoAhSPRKSsp.uusp.FhP-.-+QRGGsGsGVR+RhPGESLINPGFKSKKPAoGVDFD-	....................................................sLChls..sGstsP+aVCYCEs-tst..hstusaslhVTDAsELWSTsFoPDSLusLKA+FGLousEDhssRFRuACcQQAVsloLQED..+ASLTL.SGusSuLsFDLSKVPuPEAAsRLQALTLuLA-+VpsLERRLA..AsEcs..A.......sSPRKSsp.uGsQ.LFLPDsD.QRG.GsGsG....VRRRC..P.GESLINPGFKSKKPAuGVDFD-.........	0	5	6	7
+15238	PF15385	SARG		Specifically androgen-regulated gene protein	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9BW04	Family	This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue [1]. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.	27.00	27.00	33.60	27.90	23.30	26.70	hmmbuild  -o /dev/null HMM SEED	497	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.11	0.70	-13.05	0.70	-5.13	31	124	2012-09-03 14:58:22	2012-09-03 15:58:22	1	4	37	0	65	113	0	341.50	32	92.15	NEW	ps.sDpShcaL....otEEK-sLLFhEETIsSL.-s-h-s....slss..Dputpsp................uPp.........s.EEosspp...sEPcclh-hsps.......u.shput..shuLPcshp.hu...pspsh+cs....s.......t.pppth....s.P....pst.s.......s.Pstsssustsss.ch-hl..sPPtt....pPchtp.......psspPhs.upp.........................pcc.susEuhS.pusp+sscss.t..ps.su.sspsu.............................t.pt..sP.sAPK.s++hPsNIslpsSpu...shp.s.t......Nh.pR+spshss.sus.....sps..pcppKuRhpuLcKhGLPpDp.p-suht.......................................................................................ssuptssstshsh.hsppttspus.op....................sss........hsGhp..p.shKSpohchsusGhoshhps-...hssp.p..pp.uptShh-+hsP.sshpssR.RsuSLs...............................Rsth.RP...sloVphS....s+Gss-EpRREAL+KLGLLKE	..................................................................................sDpShcaLotEEK-sLhFhEETIsSL.-t-h-p..h.s..Dps..s...................ss.......t.cts.sp........tspphhp.sps..........s.t.t....tl.p..t.hs.....s..hppt...........................s.....t...................s......chp.h..sPP......p.p..t..............t....s...upp.........................pcp.htspshs..s.ptt..p.......t...ss...tph...............................t...ss.ssPK..p+hPsNI.lpsstu...shp.p.t......ph.ptpsps..t..s.................................p.p..t.tp.s..tp.............................................................................................s.........................................................suhp......p.shKSts..h.shGho.hhpst.................sh.t...h.s.sh.ps.R.RssSLs................................................ts.h.RP...sloVphu....s+GsspEtRREAL+KLGLL+E...................................................................................	0	3	8	27
+15239	PF15386	Tantalus	PRR14;	Drosophila Tantalus-like	Iyer LM, Aravind L, Eberhardt RY, Coggill P, Hetherington K	pcc	Manual	Family	An alpha+beta fold domain found in metazoan proteins such as   Drosophila Tantalus [1]. Drosophila Tantalus binds the chromatin protein Additional sex combs (Asx) and also binds DNA in vitro [2].	32.80	32.80	32.80	32.80	23.20	20.80	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.57	0.72	-9.25	0.72	-4.21	13	121	2012-10-09 15:10:48	2012-09-03 16:02:35	1	2	64	0	68	111	0	61.80	60	8.38	NEW	sslTPh.GLP+stR.l...pKKEhSL.EEIYTNKNYKsPsst+sLETIFEE..Pcp................+sGslhhh.s+Kh	.............NLTPM.GLPRP+R.L......pKKEFSL.EEIYTN.KNYKSPsspRsLETIFEE..P+E...................RNGoLI.hSppKh...............	0	9	12	35
+15240	PF15387	DUF4611		Domain of unknown function (DUF4611)	Coggill P	pcc	Jackhmmer:Q9BXV9	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 71 and 100 amino acids in length. There is a conserved AKR sequence motif.	27.50	27.50	27.50	57.60	24.40	27.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.62	0.72	-10.14	0.72	-3.84	9	26	2012-09-03 15:05:01	2012-09-03 16:05:01	1	1	20	0	11	34	0	90.10	53	94.44	NEW	LlGEaVspDGppQ+lRlsCEusu-usshQuLLSGlAQM+EhVoELhusLVppEtpstlsuss-Eul-.GsDEDDuED.EsNhcs+T.....sSsGPsAKR.KP	.LLGEYVGp-GpsQ+LRVsCEAPGDuDPFQGLLSGVAQM+ELVoELFusLVppEsQppVAAuP-EuLD.G-DEDDuED.EsNhss+T.....s.sGPsAKR.Ks...........................	0	1	2	2
+15241	PF15388	FAM117		Protein Family FAM117	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9C073	Family	This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.	27.00	27.00	27.60	35.90	22.30	26.10	hmmbuild  -o /dev/null HMM SEED	318	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.31	0.70	-12.52	0.70	-5.20	19	194	2012-09-03 15:06:59	2012-09-03 16:06:59	1	3	59	0	110	184	0	263.60	45	73.36	NEW	lRRTuSLDsIsusYLpGpWP+-.scs..hssp.hpDKuTQTPsuWsEpstp+p...........t....tH+RSASWGSs-pL......+E.........luKL+QQ..........LQ.Ro+p..us.........tspc+cppush.Gspus.....hstsp.........t....shss...sshtphssphRpSlEGLNQELEplal+......ppsc-phht.......l-lPDGHRAPlPs.t..t..................susspo.sspss.........u....Ssssuss.s.........s...ps.ssssp.tpsh...hs..........................................tsssP....h.thuoSP+PN+ohhFpREPPEGCE+V+l.hpE.ts.sp.spth...sCPDcNKVsFpP...sGSAFCPV.ol.hpPLh....Pos-hhh.ps.	.................................................................lRRT.SLDsl.husYL.GpWPR-..sph..hssh.hpDKAT...QT.psWsEptt-+p..............................sHpRSASWGSsDpl......KE..........IuKLRQQ..........LQ.RoKp..sSR.........pt+-K-RpSPhp.....GsHss..........hspsp..............ssPhs.h..s.s..hs..tp.ssphtsSlEGlNpElEtlhlK......tptcEplh...........-lPDG+..RAPhP.....p....................SusopolsopoPs...........tpsSs......ssp.pssss........h.....tstptSPpst.cshh..p.t.............................h-sGssSP.......l.taAoSP+PNpSYhFKREPPEGCE+V+V.FEE..h..sst..hth....h.CPDKNKV..sF.P...oGSAFC.V.pl.htPLh.....Ps.shhh...st..................................................	0	18	29	58
+15242	PF15389	DUF4612		Domain of unknown function (DUF4612)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H246	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 109 and 323 amino acids in length.	27.00	27.00	31.70	28.90	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.78	0.71	-3.48	10	88	2012-09-03 15:07:59	2012-09-03 16:07:59	1	3	69	0	58	69	0	104.90	46	53.32	NEW	GCsSAKpVusV.s--............-.spuKsauNGDshsD...EY+hKsVEcVKYh+s.....EEp+hsupsppsh........cppsptt+s+spscsuutsst.h...............slHlSESQQEFFRMLDEKIEKGRDYCS..tEE	.................................................................................................GCspuKphstl.ppc............cst+t+satsuDshsD...Eh+hcssEcsp..ps................-Ep+hsupspcsh.....ccpsssph+hpsstchsu.spt.h..............tshcI.ScSQQ-FFRMLDEKIEK.G+D..YsS-pE..c.....................	0	11	15	34
+15243	PF15390	DUF4613		Domain of unknown function (DUF4613)	Coggill P	pcc	Jackhmmer:Q9H6R7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 625 and 725 amino acids in length.	25.30	25.30	134.10	25.30	23.90	23.90	hmmbuild  -o /dev/null HMM SEED	671	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.04	0.70	-13.21	0.70	-6.35	23	69	2012-09-03 15:11:50	2012-09-03 16:11:50	1	3	41	0	44	65	0	614.70	48	94.99	NEW	ELGKGKLLRTGLNALaQAlHPlHGlAWTDG+QVVLTsLpLpsGEsKFGDSpVIGQFEHVpGLoWuPhssuDs....PuLLAVQHKKHVTVWQLs.SssEpuKhLhSQTCEIpEshPlLPQGCVWHPKpslLsVLTu+DsSVhhsVHsDuoRVKADI.pspGhIHCACWTc.DGpRLVVAlGS..uLHSYIWDssQK.TLptCSFCPVFDVsu..hlCuIpATVDSQVAVATELPLDKICGLNAutsFDlPssuE...sss..hto.s.lhs.-.hshD..ptussSEss.St.sSlu....SS....osPLDLTHIhhs+p+S-sSuLlpLR+KDaLTGoGQDSSHLlLVTF-+.cVTsTRKVoIPGILVPDlIAFssKuQlVAVASNTCNlILlYSlhs.SshPNIQQIQLEssERPKGlCFLTDKLLLILVGKQK.sTDsAFLPSScSDpYhIRLhl+Elhh---sSsosstsQsshss......hsshLspus++KhhEsLSs.-hp.ps.+sLLLsusss...pSspstRpL.IcEI......+SP.........soSss..s.....uS....l..................s...L-...scPsspssol......................s....psS......usP..s.....tssp...Es............................ss..lPp..p...psL...ppEKEsppLo+pLEtLSpshs-lQpsLSELpDhLpNGK..Ks..sssYPhSpDPPYVHIsYQKshssssls.EKRuVLLCcGKLRLSsVQQhFGLSLVEMhHu.SpWILLsADoEGFIPLTFoAsQEllI	.................................ELGKuKLLRTGLNALaQAlHPlHGlAWTDGpQVlLTsL.hpsGE.sKFGDSpV...IGQFEHVpGLtWuP.sssDo....PsLLAVQHKKHVTVWQLs.SssEp.sKhLhS.QTCEIp-shPlLPQGCVWHPKpslLsVLTtpDsSVh.sV+sDsoRVKADI.pspGhIHCACWTp.DGpRLVVAlGS..uLHSYIWDssQK.oLptC..SFCPVFDVsu..alCuIpATl.-uQVAlATELPLDKICGLNAu.sF-lPssuc...sss.....s.s.lhs.E..shD..ctussu-ps.u...Slu....SS...ssPLDLTHlhhspp+S-sssLlpLR+KDhLTGoGQDSSHLlLVTF-+.tVTpTRKVoIPGILVPDllAFs.+uplVAVASNTCNhlLlYSlhs....SshPNIQQIpLEpsERPKGlCFLTDKlLLILVGKQK..sD.ssFLPSSpSDpYhl+Lhl+Elhh-c-sososstsppsh..ps......hss.lshssc+KhhEsLus.-hp.ps..+sLLlsssss...QSspstRpL.IcEl..+Ss..........ss.sssSh..................s.Ls...scPsspssol...............................sp.o......sss.s..tsph...ps...............................sphsp..p...psh...tpE+phtpLo+plEhLstshs-lQpsLSELp-hhpNG+..+s..sssYP.Sp-sPaVplshQKs.h..sssh..E+RsVLLCcGKL+LsslQphFsLollEMhas.s.WIlLsADs-GFlPLpFpupQElhl...................................	0	7	9	21
+15244	PF15391	DUF4614		Domain of unknown function (DUF4614)	Coggill P	pcc	Jackhmmer:Q9H6X5	Family	This domain family is found in eukaryotes, and is approximately 180 amino acids in length. There is a conserved EALT sequence motif.	25.00	25.00	26.60	26.60	19.20	18.70	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.30	0.71	-4.51	21	53	2012-09-03 15:12:47	2012-09-03 16:12:47	1	2	44	0	35	45	0	166.20	47	32.84	NEW	psossssYS.-DFEpSsp.spsspss..spSpposspohs..opS-tS...ushposhs........tshps...pcppsps....spclhlK.EsAVQT.....csshsh.Wsp...ssuhAslGPslGuuYVDPsPIAoHVlSsDAlEALTAYSPAslALsDMLKQQLsLTQQFlEsSR+LHtSLlpSL-t-saHYpTLEETKEYIRcHRss	..................................s.s.sssYS-DFEpSsp..psopsp..spScpS.s+Tls..shS-.S.........uShposhs..................pshps...p+cpscp....ssRlhVK.-sAVQT.....-PuFsYpWsc...suuhAshGPuLGu.uYVDPsPIAsHVlSADAIE..ALTAYSPAslALpDhLKQQLsLTQQFlpsSR+LHtSLLpSL-t-sFHYHTLEEsKEYIRpHRP.s....	0	9	11	18
+15245	PF15392	Joubert		Joubert syndrome-associated	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H799	Family	This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis[1].	27.00	27.00	30.50	30.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.12	0.70	-5.21	12	56	2012-09-03 15:16:48	2012-09-03 16:16:48	1	1	35	0	30	46	0	293.90	54	20.35	NEW	PLQMTGLTDIADII-DLITKcGVSS-ELGLTEpQA+sISRIQ+oSGR+PQRT-cERREIQlWMKRKRKERMAEYLNQLAEKRGQEHDPFCPRSsPFYMTSREIRhRQKMKHEKDRLLLS-HYSRRISQAYSLMNELLSESsQLPssAQKPLPs+PpTsphsRpQ+ssSPRRENpHGHNFPlNRPGKsRaIS.KsSahpKG+PhspspGSsh.................................+GSssPspShQps+s+tuAGLsP.ocQVClEYEREETVVSPWhlPS-I+cILH-sHuSLLQDlSPs.EEEPEsP.....htluGhDSlSESTGSILSKLDWsAIEDMVAuVEDKuLSVHWA	................................................PLQMTGLTDIADII-DLIsKcGVSS-ELGLTE.QA....pshSR..I.Q+sS.G.R..+s..Q...R.T-KERREIpsWMKRKRKERMAcYLspLAEKRuQEHcPFC.PRss.P..hY...MTSREIRh+QKMKcEKD.RLLLS-HYScRISQAYuLMNELLSESVQLPsss.pK..PLPs+s.ps.sp.sppQ+.ssSPRt.ENpaGHsh.lspsuKs+ahS.+PSahpKtcshs..spGss..t............................................................cuSssPs.p.p.h+pptsstlsP.sppsC..lEhERE-pVVSPWtlPs-I+pIL+cspsSLLQDhS...ss.EEc.c.s.......hsGhDSlSESTGSILSKLDWsAlEDMVAuVEDpt..s................................................................................	0	4	6	14
+15246	PF15393	DUF4615		Domain of unknown function (DUF4615)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H7E9	Family	This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 161 and 229 amino acids in length. There is a single completely conserved residue F that may be functionally important.	27.00	27.00	28.80	28.80	26.40	25.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.94	0.71	-3.89	33	85	2012-09-03 15:17:45	2012-09-03 16:17:45	1	3	70	0	55	85	0	127.30	38	57.03	NEW	cQhcpELsWClpQLEhuL...pstK...opKQtc...-sh+sl+sL+SspsPLlKKRQlM+sthGDYRsKMppEc+Khh+shpshtho.upsps....s+Ku.Fh++uthh..................................sotc.s.phsa.hspp..................................................................pF+FNF	....QhppELsWCVcQLElGLcppKs...o.KQtEpuhpsI+oL+Sp+sPLs+KRQlM+shFGD....YRupMctEppchh+shcsstho.upsps......s+K...h.++sthh.................................pst.t...phphshshspp....................................................................................pF+FNF..............................................	0	20	25	39
+15247	PF15394	DUF4616		Domain of unknown function (DUF4616)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9H972	Family	This protein family is a domain of unknown function found at the C-terminal domain of the proteins. This protein family is found in eukaryotes. Proteins in this family are typically between 166 and 538 amino acids in length.	27.00	27.00	27.50	27.50	23.30	26.60	hmmbuild  -o /dev/null HMM SEED	537	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.88	0.70	-5.49	7	55	2012-09-03 15:20:01	2012-09-03 16:20:01	1	2	30	0	25	44	0	360.90	66	96.47	NEW	SFSATILFSPPsG.uEA+CCCCuCKSEssuusous.sGs.P...ssTPITVTGcGLAVQSoEQLLHlIYQRV-KAVGLAEAALuLA+ANNELLK+LQEEVG-LRptpssp.--ssputtpssPscpss.hctSsGcA.pshs..u.EEEs-ulGoGVQVVIEELRQLGAAuu.ssGsLG.FsssQcchchPGCsLAu...sEuuPLLNPh.....DDYluoEGslQRVLsPuaAKQLSPuoQlAhppusu-su.EshschssspPcshLuusAsL....DuAL-..-ssPGuo.......GElphSLG.......assoPsRsRGoGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSESIKSSWNISVVKFLLEKLKQELVoSsHNYTDKELKGACVAYFLTKRREYRNS...LNPFKuLKEKEEKKLRSRRYR.LFANRSuIhRpFuPEDQ+LWcsVTEELMSDEEDSLsEPGVWVARPPRFRAQcLTcLCY+LDANSKHGTKANRVYGPPSDRLPSAEAQLLPPcLYNPsFQp-.s-uGspsuPsSsshspsHKohCPDLNSFIEIKVEKDE	......................................SFSATILFSPPuG.SEA+CCCCACKSEssuussGSpGGs.PP...suTPITVTGHGLAVQSSEQLLHlIYQRV-KAVGLAEAALuLA+ANNpLLKpLQEEhG-LRptpss..tct...s.ttt.P....t..c.u.Gcs.p.......................................h.assspp.hRhPGCsLsu...s-usPlLsPh.s...DDYVASEGulQRVLVPAYAKQLSPATQLAIQRAouEousEsGsKLPssRPEDhLsusAsL....DuALE..EusPGus.......GELphSLG.......hssSPsRsRGoGQKNSRRKRDLVLSKLVHNVHNHITNDKRFNGSE...SIKSSWNISVVKFLLEKLKQELsoSPHNYTDKELKGACVAYFLTKRREYRNS...L..NPFKGLKEKEEKKLRSRRYR.LFuNRSpl.hchhusE-QphWpsVTEELMSDEE.DShsE.PGVWVs+sPpaRu......LTpLsh+lDAts.cpG.sKtpRh.G....S-RLPSsEsQhhP.cLaN.pap....tt...............tss.......+cs.s...sSFlplKVEcD...............................................	0	6	7	11
+15248	PF15395	DUF4617		Domain of unknown function (DUF4617)	Coggill P	pcc	Jackhmmer:Q9HCM1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 702 and 1745 amino acids in length.	27.00	27.00	48.00	48.00	15.90	15.40	hmmbuild  -o /dev/null HMM SEED	1068	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.01	0.70	-14.29	0.70	-6.51	14	45	2012-09-03 15:22:00	2012-09-03 16:22:00	1	2	30	0	25	50	0	865.30	45	67.36	NEW	SMELLATCLSLWKKQPSEssE........EKQsN....pSppNpT..ulGlS+Psc.lss+uspSssGN...SQsKhl..s.ppThLSsllQNaESSusslsKGTELQIAVVSPLILS-l+TLS.hKslsPpslPEssYPVIKEGSlCSLQsQ.hsENs.lsA.sLKssl....spPVuSossSsKl.s.LhQ....KEKQ..scsopuss-sssssspGpp.t....p....sshuspQss.co+...........................................cSslVsuDhLQI-sICSLVEGDsSYNSQIAcIFNSsPhp+VEPQKsShPsppslSstpQcEQl-ps...TEs+DhuhQc-ch.lpsTDlSpc.ls-.scs...P.......tc.u..............Stphlcsssuhl.EEuslE+..............hspc...sssslsSs..AuhpQDspspEsDssu...Nhsu.ps.PstsEl.s-.ppslhYL+DQLSELLKEFPYGIEulN..s....+csSVupphspplsc-QTssKps..sDSK-...ssDQIpITlLsS-QhKELFPEpcppss.......csD+lsEsQp.EKsls.....EsusQCDsQss.ppsEopDSs.hsSEKDcl+CC.ALGWLSMlYEGVPpCpCsSlcp.sSpE-Ksc-Qsush.-oNSsKQGEpsScsDlslhc...sss.lsss...PKss....ss...cs+hschcp..c...sh...........................KDtopT+...csoph+sEQ-...ss..QhpS.....KsD.Kh................-shQspK+p.pLpaHEVsFpousK.pt...c.hSQEu......Lp+KhhsQsspPlKsKsshhss..K..D......hh+cssSlhQolSsEKhKlKhpu....hp....pt....EKRKlDpsphh-..ElKKKKp-KQEQN+NsG.ss....hKLssplspsNERA.lpEp.s.....luss.....cSSD.K...sSSsKhp+VlospEY.LQRpKcK-shu.ppsuK+hpl....csVsscSpah+sS..Khsspl.tSssKss-+..psSuhpTsKEshNshss+uKsLKhH+..SE..pSKoaslSpNsKGpsDGKQsDKhhh-Koh.DK.lsplsNEhp.s.hs.QsK-QRKpYLNRVAFKCTERESICLTKL-sSP+K..Lp..K-..K+..p......-sKscs...lssK-socKssMLEFKLCPDlLlKNTsosE-ppshpspPcKEQAsVQVSGIKSTKEDWLKClss+.K+M.EusQE.....D.s.l..sS+Lu+RShSADGhEsLQNPVKDSKsMFQTYKKMYLEKRSR	...............................SMElLATCLuLWKKQPS-ssc........-Kp.s....p.ppspT..ssuhSpPsp.hp.csshSshGN...Spschs.s..ppTsLshlsp....saESouhslsKGoELQIAVVSPLlLS-l+ols.sKslsPt.s.lsEslYPVIKEGSVCSLQsQ.hsEN..ssA.uLKssl....stsVsuossuschhs..hp....KEcp..scsspsss-ssss.spspp......p....sshsspQ.s....ps+...........................................sossVuuD.hLQIssICSLVEGDsSYNSQIAcIFsS.PhphlEspKsShPsppshus.p.ccQl-ph...sEscDhshppsp..lpsTDlspc.ls-tsc....P........c.u..............o.p.lcsstshh.Ecssh-+..............hscc...sssssCS...uuhppD..spEhDsss...........shss.pc.PstsEl....s-.ptslhYL+DQLSELLKEFPYGIEsls..s.......+csSVsQQhs.phsc-p.TssKss..sDSK-...ssDQIpITlLsS-QhKElFPEpcpps.........sDcLtcspp...-csls.....-s.s.ss...phstttc..s.Dsh..so-KD-ltCCALGWLSMlYEGVPpCpCsuhpp.sSppcKtcpQsu...cssSscpsE.psucpslshhp....ps.lsss....Pchs.....st...cschschpp..p...sh...........................+phspp+...cps..psEpc...ssph.S.....psc.p.................ss.pppKtt..lph+ElpFpspsK.hh......SQEs.......ppKhhsps.tPl...KsKsth...ss..p..D.......hh+psShsQolSsEKhKLKhtu....hp.h....pKRKlDpsphhD..ElKKKKa-KQEQppssG.so....hKLssplopsNERAhlpEK.tloss.....cSscsK.....sSSsKhs+llTspEY.LQRQKcKEshu.spsSKchpl.....csl.scSpah+sS......Khsspl.tSsGKssE+..psouspTsKEShsshosHGKslKhH+.....Sc.....-S+oasl.+NsKtpssGKQsDKhah-Ko.h.DK..sphsN-hphsphs.Qs...K-Q+K.YLNRVAFKCTE+ESICLTKL-sSP+K..Lp..+-+c..p....-sK.ps...hss+css-KssMLEFKLCPDhLl.KNosos--ppchpstPcKEQAsVQ.VoGIKSTKEDWLKtlspcp+h.c.ssQch...D.sl..sS+ls+RohSADshEhLQNPlKDS+tMFQTYKpMYhEKRSR................	0	1	1	5
+15249	PF15396	FAM60A		Protein Family FAM60A	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q9NP50	Family	This protein family, FAM60A is a family of proteins is found in eukaryotes. It is known to be a cell cycle protein that binds to the promoter of a gene transcription repressor complex, named SIN4-HDAC complex. This means that FAM60A has an important role to play in 'switching on' gene expression [1]. Proteins in this family are typically between 179 and 324 amino acids in length.	27.00	27.00	58.70	45.90	20.80	20.50	hmmbuild  -o /dev/null HMM SEED	213	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.78	0.70	-4.59	17	107	2012-09-03 15:23:46	2012-09-03 16:23:46	1	2	64	0	60	90	0	190.90	61	71.84	NEW	FuFHKPKlYRSssGCCIC+AKSSSSRFTDS+KYEc-FhtCFtLpE..pRsG-ICNACVLLVKRWKKLPsGScRNWpH.VVDAR.AGPGhKshspthpK.+pht....................hcp+ph..+http++pp.............ss...shsp.........spssSpspSPs.SspS--sspt...................................c.............tptpsp.sl.ss..FlD.oYWKRpclCCGhIF+G..aGEl..llDPcLhKPCssspc	..........FGFHKPKhYRSh-GCCICRAKSSSSRFTDS++YEK-FppCFGLpE..sRoG-ICNACVLLVKRWKKLPsGSKKNW.NHVVDAR..AGPuhK.hsh+PKKhKshs.........................tp....thppp.hp+lpKchKpp..................................sSD......ApSo..........TSSsSPsQSPshSNpSDDuu-s.........................................................Eh............tstpscssl.hS..FLDhoY..WKRp+lCCGIlaKG.paGEV..lIDs+LaKPCCsp+.p................................................................................................................................................................................	0	14	17	36
+15250	PF15397	DUF4618		Domain of unknown function (DUF4618)	Coggill P	pcc	Jackhmmer:Q9NUD7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 238 and 363 amino acids in length. There are two conserved sequence motifs: EYP and KCTPD.	27.00	27.00	27.00	30.80	26.20	25.80	hmmbuild  -o /dev/null HMM SEED	258	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.67	0.70	-5.05	17	62	2012-09-03 15:26:35	2012-09-03 16:26:35	1	2	38	0	31	53	0	217.00	45	74.36	NEW	l+sR+soL....pELppHcshLschNt-LhcpIQDhEcoTshpVRphLpQQ-lhsollslLEauNc+cLpphKsELQEWcEKpcs+hspLcpQlcpLcu+IcKspEElsFLSTYMDHEYPVKuVQIAsLhRQlQplKDsQQ-ELD-LsEhpctVLtolus+hppKccplLpulshKs.pPhppsLlp+s.hcsQshhKphspaRchIcphcE-lPhL+AEVcpLpsphp.csRElIFtDl.LLR+PKCTPDMDVlLNIPsEEhLP	..............l+st+suLpELps+csaLsKhNp-LlcsIp-hEsSTsLpVRtlLQQQ-hhsollDILEYsN+K+LQph+uELQEWEEKccsKhshLpQQs-QLsu+IcKspEEVsFLSTYMD.HEYslKuVQIusLhRQLQplKDsQQDELD-LsEMR+pVLpoLSs+IQcKc++lLpolVscsppshpp.sLlphh.hcspthh+ph.ta+c.htthpp.h..L.tplptht.p...p.pp.ha.ph.hhphsKCpsp.tl.lpIs.pp....................	0	9	10	15
+15251	PF15398	DUF4619		Domain of unknown function (DUF4619)	Coggill P	pcc	Jackhmmer:Q9NVL8	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 128 and 299 amino acids in length.	27.00	27.00	33.60	33.40	25.60	25.00	hmmbuild  -o /dev/null HMM SEED	296	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.05	0.70	-12.00	0.70	-5.00	10	52	2012-09-03 15:31:30	2012-09-03 16:31:30	1	2	30	0	27	46	0	211.30	53	96.47	NEW	MGLuaSKuHPRVTKVAPLQsKEtETPsAGslDFshsQNLEE+S.aohARLQDpsKuLEGQLPPLREThYGRYSo...ssRsMYFDIPLEpGETSIIKRHPPRRhQKLEPlDLPQVlTScRLLSQpEAc.ssp+AK..QELEK+MQospYoSGKRQYLHKMQMLEMNRKRQEAQhELKKoLH+EARINKQ+.R-HKAKKlLpolPRNDDt.DllThLP-c...sLNRsPGNupNuEFL.pHQstNsYsPRKsGKhEsWlpEQEApGQLhWDSSSSDSDEhG+-EKK...PRALVRTRTERIPLFDEFFDQE	..................................MGLu+SKsH.RVhKVAPLQs+E.Eossss.ltFshppsLEEco.h.hsRLQ-pp+shEGQLPPLpEshhGRh.s...ssRsh.FDIPL.-p.tETSIIK+HPPpRhQ+LEPh.shPpshTutph.spppst.thp+t+....hEK+hQs.hasstpRQaL+KMphLEh.p++QE.....sQhE.....L.K+sLpt-s+lsppp.c-cpucKhhpshs+...sssh....chhshlPsE...hlsc.ssGs..stth..t.p......s.p.s.ht.h.hpp.hptph.h-sSSosS-t.tc.p++.....sLVRT+Tp+IshaDpFhD...............................	0	4	4	7
+15252	PF15399	DUF4620		Domain of unknown function (DUF4620)	Coggill P	pcc	Jackhmmer:Q9P2W6	Family	\N	27.00	27.00	149.60	51.40	25.40	19.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.70	0.71	-3.94	2	9	2012-09-03 15:33:08	2012-09-03 16:33:08	1	2	6	0	1	5	0	98.40	84	76.38	NEW	VPRWPHLS.QSGlcsPshWTtoPG.PSRDQpAPGs.MPPsAAQPSshG.LVPPATA.E.lDcPA.HWLACsCCLuLPuQLPLAIhLGhsL.LcuuP.sGKLCP+ARRWQPLPS	.VPRWPHLSSQSGVcPPDRWTGTPGWPSRDQEAPGShMPPAAAQPSAHGALVPPATAHEPVDHPALHWLACCCCLSLPGQLPLAIRLGWDLsLEAGPSSGKLCPRARRWQPLPS....	0	1	1	1
+15253	PF15400	TEX33		Testis-expressed sequence 33 protein family	Coggill P	pcc	Jackhmmer:O43247	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 147 and 280 amino acids in length. There are two conserved sequence motifs: NIRH and SYT. The function is not known.	27.00	27.00	46.70	45.70	26.10	19.40	hmmbuild  -o /dev/null HMM SEED	140	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.16	0.71	-10.60	0.71	-3.78	7	37	2012-09-03 15:36:24	2012-09-03 16:36:24	1	1	29	0	23	35	0	134.30	63	56.81	NEW	SlIPsNIRHKFGSplV-pLlSEEQstp....slschhEtppt.souhPs.hTcs.scl.oohhssYaDLGhshRssLh..GsspETKSLMpuSYTsEVhE+uVRDlEHWH.GRKTDDLGRWHcKNAhshNLQKALEE+huEpsKs+us	...........ShIPsNIRHKFGSphVDpLVSEEQAp+....AIsEshEGQKR...sSuWPS.RTQoPhcl.oSlFSDYYDLGYNMRSNLF....pGuPp.ETKSLMKASYTPEVIEKSVRD..lEHWH.GRKTDDLGRWHpKNAMNhNLQKALEEKYGE+SKS+u...	0	3	4	6
+15254	PF15401	TAA-Trp-ring		Tryptophan-ring motif of head of Trimeric autotransporter adhesin	Coggill P	pcc	Jackhmmer:Q48152	Domain	TAA-head_Trp-ring is the tryptophan-ring motif of some Gram-negative Enterobacteriaceae. The Trp-ring folds into a beta-meander type on the top of the head domain of its trimeric autotransporter adhesin proteins. In conjunction with the GIN domain it is thought to be the region of the head that adheres to fibronectin.	18.60	17.30	18.60	17.30	18.50	17.00	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.59	0.72	-9.38	0.72	-3.75	23	175	2012-09-05 12:42:40	2012-09-05 13:42:40	1	29	47	1	31	163	2	64.50	44	11.54	NEW	VssspKsNGKtsc.....VKlGsKh.hhpcc-hclhTGKs.................p.ss.sssssssssssspGsGlVTupsVh-..Al	..............hpsKsNG+pTp.....VKlGAKT...uhhp.cKDucl......hTGKsh....................................................s..sss..ssTspGpGLVTAppVl-Al................................	1	1	1	31
+15255	PF15402	Spc7_N		N-terminus of kinetochore NMS complex subunit Spc7	Coggill P	pcc	Jackhmmer:O59757	Domain	\N	27.00	27.00	27.60	27.60	24.60	26.40	hmmbuild  -o /dev/null HMM SEED	927	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.08	0.70	-13.83	0.70	-6.54	19	122	2012-09-06 11:41:45	2012-09-06 12:41:45	1	10	72	0	106	126	0	496.30	28	58.18	NEW	hDKENsTsDluusp..ts.....hsup-KKSRSKSLGPGGLD.ALpsuNGNRRKSsss...hPLKSILKPTlPVSPlpsIPoF-ETR++oPs.........t.t...ptptt.hIshsssstsshsus-p.sNPFDsFsssu..p.......stt-.p.AAAREREE+ER+E+E+c...sILE+R-ARRKSM...................ANRRVSFAPEATLHTWNVVEls-DSToSSuu.NSTRRASSLs.ts......ppsststp.sps.s....pt.t-sshu.SPsp..cLpphppp..pu..s...ss...pphuSSPaSGuSssus-.tulps.t............-.sssSosss.DupuTsMSh--hTspSsuosts.s..tsSosSSu+L-EuLRpAApc.AGTpuID.D-s.s-hSMEhsspEIsGAFpPWlKKu.pppsh-hE.........................DlouchDQENlsP...sstshp.ppsssppsss-..pts.................p.....DhSMDlTpAlGGIlsptpsppp.....shspRpS.u...............t.oshs-QTMEFTsVVGGItpstSstputsssps.ttDE-MTMEFTSslGGVLspshspssspptptt.s......t.........ppssstpss.-MEMTuAVGGILsshpEptp..p..........DpThGM-hT.sAlGtILssthsspsc..ppthhthps-tst.p.sSSPFQtslh.SPs+.ssss....+hsslsSEsGSPoluSl+s+psR.pS.sppsusosssp.os.psSPh+.sshpss............pptsspsspssTPs+TPPSp.phshRuuSP+Klhps-hptsuop......ttssspc......sLFppss.TGpoTPtFVLpPp.....pRRSSGlGID+-GLGSPRVAtlLDRRRSIGE-AtcFlPpp.....ppuVRF-DPhcLpEElD+ERp-EEp+Esu+..lpt.sst...-+DsThNL+-MISSLT...PKKNKL+GRKSLHVGAA+GLLGKRPsELDpD----ssps...sKRLKG.+p.uSPVKsI+LPAPPSKsETs	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................-hsM-hTpshG.tI..h....................................................................p.sh-h...h..tu.........................................................................................................................hc.p..........................................................t...hchp..s.ttlh..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	21	52	87
+15256	PF15403	HiaBD2		HiaBD2_N domain of Trimeric autotransporter adhesin (GIN)	Coggill P	pcc	Jackhmmer:Q48152	Motif	HiaBD2_N may represent the GIN domain of the Head region of TAAs - trimeric autotransporter adhesins. Not all TAAs carry this domain; however, in those that do, the GIN in combination with the Trp-ring domain is necessary for adhesion to fibronectin in the host cell.	25.00	25.00	30.40	30.40	18.80	17.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.84	0.72	-8.35	0.72	-3.82	19	46	2012-09-06 14:40:45	2012-09-06 15:40:45	1	14	15	3	0	47	0	53.10	45	7.47	NEW	TNVsSGL+sYGDTs...hsssssussshs+ps-..sAapGLlNLsEKuu.....s.ps...shVuD	.TNVsSGLKsYGDsN...FsshssSsssls+psD..sAYcGLlNLsEKuu.....sKp..hVAD..........	0	0	0	0
+15257	PF15404	PH_4		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:Q03868	Domain	This Pleckstrin homology domain is found in some fungal species.	27.00	27.00	30.50	35.60	22.80	19.90	hmmbuild  -o /dev/null HMM SEED	185	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.40	0.71	-11.26	0.71	-4.76	32	91	2012-10-04 00:02:25	2012-09-10 15:36:12	1	3	89	0	65	98	0	169.50	38	15.94	NEW	hsGhLYpKs++HosFpchhVlLssGhLllFpshhRs.hoGhthp...plcap+hhslsLp-CYlYSGhlTc.DLLppspsaDs...........hsPGp+ulPRlY..sDGWpSs---sspsFslWasp++shhcppts.tp.........................................t..tpstsph+hVspLGssG+S.hVFhARSRtERDhWVhuItsEl	.......hSGhLYpKs++HusFpch.VlLssGhLllFpshhRp.hoGhths...psaap+hhslsLpDCYlYSGhl..Tp.DLLhpspohDs...........spPup+ulPRlY..sDGWpSsD--sspsFslWasp++slhpsppp.tp............................................tpsppph+plspLG.ls.G+S.hVFpARSRtERDhWVhuItsEI..........	0	21	37	56
+15258	PF15405	PH_5		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:Q9Y7U6	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.87	0.71	-4.22	42	284	2012-10-04 00:02:25	2012-09-10 15:41:14	1	12	152	1	212	344	0	136.40	27	11.08	NEW	llaKG.LKK+sssptps....DlpsYLFDHALLhlKhKtlsKtEpaKVY+RPIPLELLhls..........h--hsst.t......pps...........sshlsppssssst.s......pt..pssasITFpaLG+pGYp.lTLYAushsuRppWlEpI-pp.Q	.................hlhputLp+tsspp...s...-l.psaLFD+h...LlLs.+..........h...+s......s......s......K...p...c...p..ac..Va+.......cPIPlcLLhlp.....................................shp-s.sthuh..........................s...............................sshhs.stssssst................tps...p.haPlshp+LG+psh........hTLYAssttsRpcWh-pIppt....................................................	0	62	116	179
+15259	PF15406	PH_6		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:O94356	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.20	30.00	29.80	29.60	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.92	0.71	-10.62	0.71	-4.02	13	72	2012-10-04 00:02:25	2012-09-10 16:46:12	1	1	72	0	58	96	1	108.00	51	19.22	NEW	NFlYoKcFFWFGo.-A...VE..sKsLSuahcu.....-h..tss...AHHssAWAocTGKGLLFFuc.tsDKA.uPsGlIpLADASEPssDGssKFHFTu.KGHKHTFKAuosAERDNWVuQLKsK	............................hhFoK+FFaFus.-A....VE..sKpLosYhps.....EK.....ps.AHsssAWASQTGKGLLFauK.+spDKu.sPsGlINLAD..s..o..-lsp-G.usc...FpF...ph.pGpKHoFpAussuERDsWluslcsK...................................	0	10	27	47
+15260	PF15407	Spo7_2_N		Sporulation protein family 7	Coggill P	pcc	Pfam-B_51974 (release 26.0)	Domain	Spo7_2 constitutes a different set of fungal and related species from those found in Spo7.  This domain is found in general at the N-terminus. In many members the domain is associated with a Pleckstrin-homology - PH - domain.	25.00	25.00	26.10	45.50	24.20	24.60	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.49	0.72	-8.97	0.72	-4.51	30	67	2012-09-10 15:57:22	2012-09-10 16:57:22	1	2	66	0	46	70	0	65.60	35	6.14	NEW	cthsIP+sSFTAhRLsYsSspcLShoS+slhLGsIPphWhps+ppshh+sh..hph.sppps+ppspssp	......p..hslsppSaTA.+Lp.........asSPpcLphoSRphFlGsIPctWhps++cpha+sh..hph.pphpsRptohss.p...	0	6	20	38
+15261	PF09061	Stirrup		Stirrup	Sammut SJ	Bio::Pfam::PfamLiveDBManager=HASH(0x4ef6130)	pdb_1dq3	Domain	The Stirrup domain, found in the prokaryotic protein ribonucleotide reductase, has a molecular mass of 9 kDa and is folded into an alpha/beta structure. It allows for binding of the reductase to DNA via electrostatic interactions, since it has a predominance of positive charges distributed on its surface [1].	25.00	25.00	25.20	150.50	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.02	0.72	-9.62	0.72	-4.07	3	5	2012-09-10 18:18:52	2012-09-10 19:18:52	1	3	5	1	3	5	0	79.00	80	4.54	NEW	GuFGLoLNFNAFKEWAS+YGVEFKTNGSQTLAIIsNEKVSLGQWHsRGRVSKAVLVKMLRKLYEsTKsEEVKRMLHLIE	GsFGLoLNFNAFKEWAS+YGVEFKTNGSQTLAIIssEKISLGQWHTRGRVSKAVLVKMLRKLYEATKsEEVKRMLHLIE	0	1	1	2
+15262	PF15408	PH_7		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:P78953	Domain	This Pleckstrin homology domain is found in some fungal species.	20.00	20.00	20.10	20.20	19.90	19.70	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.44	0.72	-10.23	0.72	-4.15	2	2	2012-10-04 00:02:25	2012-09-11 13:50:59	1	1	2	0	2	11	0	103.00	27	10.99	NEW	EGYLYh.Ecuulp+RFshLpuK.hsh.t-KGG..LsoFpLppolluhPhsphppAssN.GlsA.GhLhhusstc+lphFAsStcshppWlpshNp.uhtls+uo	..........EGYLYh.....E..cuulp....+R..FshLpuK.hsh.t-KGG...L.soF.pLppolluhP.hs.phppAs.sN.....GlsA.Gh...Lhhuss.tc+lphFAsStcshppWlpsh.Np.uhtls+uo........	0	1	1	2
+15263	PF15409	PH_8		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:O13944	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.43	0.72	-9.96	0.72	-3.91	11	458	2012-10-04 00:02:25	2012-09-11 14:08:28	1	13	185	0	226	895	10	89.10	43	10.24	NEW	GlLLKKRRK+hQGas+RaFsLshptuTLSYa+sssus..sLRGphPlslu.lIuANtcsREI.IDSGhEVWpL+ApNcpDFpsWscAhp+s+	..............GalLKK.R+h....LKGW+KRaFsL...-s..GhLpY...h+...sp...pc..h.........+l..+....Gu....I.s......l.u....Lu....lh...S.....l.p....K....+.u...+...c........I...-...L....D.o...t....p..c...I...YHLKspopc.FptWVspLcp..pp..........	0	44	84	151
+15264	PF15410	PH_9		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:O13690	Domain	This Pleckstrin homology domain is found in some fungal species.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.46	0.71	-3.95	16	917	2012-10-04 00:02:25	2012-09-11 14:15:48	1	73	189	3	531	1121	1	111.50	33	7.42	NEW	YKpGalhRKhhh-ssup+sPhG+RuW+hhYshL.+shVLYLaKs......Ep.................thcsuphpp..o...........hpNu.....IplHHuLApp..AsD....YsK.KpaVF+LpTA-tupaLFQTssscEhQpWlcsINaVAA	..................................................................cGhLtRK.p.c..h-s..s..s.K+..s.........upR..uWcph....YsV.L..cst....LhhaKD.......pp.............................................................................p..tpu.h.st.....t............................................hcps........lsl....+.c.A.lssh......As-..........Y.p..K...+paVF+L.....p.hs...D..sspaLFQApsp--MpsWlptI..................................................................	0	135	197	357
+15265	PF15411	PH_10		Pleckstrin homology domain	Wood V, Coggill P	pcc	Jackhmmer:P40995	Domain	This Pleckstrin homology domain is found in some fungal species.	27.50	27.50	27.70	27.50	27.10	26.80	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.47	0.71	-3.91	39	249	2012-10-04 00:02:25	2012-09-11 15:43:54	1	24	148	0	185	253	0	117.60	29	12.77	NEW	l-pFGpLLLaGhhsVh..K......s.......ct..E+EaclYLFEclLLCCKEhpss..+......ppsp....p.uht....p.t..........p....ppps+LpLKGRIahp.s.l.sclhsh.u.c........s..GpasLpIhW+uDst.l-sFhl+FpsEEphcpWtssl	.............................ppFGcLhhaGphpVt..+.....................s.....pp..pE......hcsYL.....F..pchLlCsKEhpss...p...................pptp....ttt.t.t........................................tppps+hpLKGRIhhp..pl.pclhsh..s.p........................sphpLplth..............usst..lssFhl+aps-cphcpWppsl......................................	0	52	101	157
+15266	PF15412	Nse4-Nse3_bdg		Binding domain of Nse4/EID3 to Nse3-MAGE	Wood V, Coggill P	pcc	PF08743	Domain	This family includes Nse4 and EID3 members [1], that bind over this region to the Nse3 pocket, in MAGE family Pfam:PF01454 [2].	18.50	18.50	18.70	18.50	18.40	17.70	hmmbuild  -o /dev/null HMM SEED	56	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.16	0.72	-8.40	0.72	-4.12	87	205	2012-09-12 13:26:22	2012-09-12 14:26:22	1	7	173	0	145	200	1	64.60	27	16.30	NEW	DuchLV.so-Lutc+sppLphs...ssuhDs-cFls+hhsaMttp..............ssttsssppp	....Du+hLV.AoDLutc+sppLp.s...tsuhDhccFlsphlsaMttp.ht............tp..........ttt.p.....pp...........................	1	37	65	107
+15267	PF15413	PH_11		Pleckstrin homology domain	Coggill P	pcc	PF00169	Domain	This Pleckstrin homology domain is found in some fungal species.	30.00	30.00	30.00	30.00	29.90	29.90	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.54	0.71	-10.50	0.71	-3.82	7	262	2012-10-04 00:02:25	2012-09-12 14:36:45	1	17	124	6	153	1119	8	108.70	26	18.63	NEW	hcGalh....+pts+..hpsW+pRahlLc......sshhcYYcs.................................pcshhptshphuhphhplps.t....sshphphppphth.............s.tpphhhpscsp-pphsWlptlppt	..................pGhhp.....Kh..s....sp.....tc....ua+pRWFsLc.......-tpL.YaKs............................................................................................s......h.c..sh..t.p..........tp..s....t..h.....u.s.c..t..p..t........h..s....s..hpsh.........ssp..u.p..p....h....t.c.s..h..ol.......................................hTs.p.+.phhhpscocc-pt-Wlpulp..s................................................................................	0	36	80	107
+15268	PF15414	DUF4621		Protein of unknown function (DUF4621)	Coggill P	pcc	JCSG:Target_394740-GS13541A	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 350 amino acids in length.	27.00	27.00	767.00	766.80	21.10	18.70	hmmbuild  -o /dev/null HMM SEED	329	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.06	0.70	-12.15	0.70	-5.75	4	5	2012-09-14 08:43:32	2012-09-14 09:43:32	1	1	5	0	1	6	0	329.00	99	93.47	NEW	YDLSDVNTDDAVMGESWVAPLGTGYVTSDDVVNVEKVPSIREVDGAYVMIYDGEMKIKGKSLRAASsKVEIASEDITTGDIDGLFDGDFVLALTNPHITLKSNVKNASLDCSLSIEAENTSKKEATSSDFTLSTVSPNIWIGPLDPKTDAFKFVKNEKLPGIVQIVPQKIHLSLSADSKQWTNAPADALSELRYAVELPLTPAPEFSAVSVERIEDAFDEDFVDYIFSDGSARIYGEVTNEMPFDMSIEMVIMDENNVPVDIQFPAQEVKGQSGEVIFEITKEDMPKMKDARHIDLNLHLTGRDQGEALKKGQKTTFNLKLKKEGGISI	YDLSDVNTDDAVMGESWVAPLGTGYVTSDDVVNVEKVPSIREVDGAYVMIYDGEMKIKGKSLRAASDKVEIASEDITTGDIDGLFDGDFVLALTNPHITLKSNVKNASLDCSLSIEAENTSKKEATSSDFTLSTVSPNIWIGPLDPKTDAFKFVKNEKLPGIVQIVPQKIHLSLSADSKQWTNAPADALSELRYAVELPLTPAPEFSAVSVERIEDAFDEDFVDYIFSDGSARIYGEVTNEMPFDMSIEMVIMDENNVPVDIQFPAQEVKGQSGEVIFEITKEDMPKMKDARHIDLNLHLTGRDQGEALKKGQKTTFNLKLKKEGGISI	0	0	1	1
+15269	PF15415	DUF4622		Protein of unknown function (DUF4622)	Coggill P	pcc	JCSG:Target_390149-GS13960A	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 348 and 360 amino acids in length.	20.00	20.00	21.90	495.10	18.10	17.70	hmmbuild  -o /dev/null HMM SEED	310	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-12.03	0.70	-5.65	3	9	2012-09-14 08:50:26	2012-09-14 09:50:26	1	1	9	0	2	9	0	313.90	71	89.46	NEW	GKVpV-sQLGGpYuIhS....PDAQTRAssssG.ssL+D....splhLLs-GSTLWLshhcpAKsGTTptT...QGYVVR.TGTGGssoLYPC.psDE.NGcl.I..su..SuTPLYLcAGTYpF+hISPAKAlsoDGKssIcNGEYLlATDsRYTQTtSTslsIotlsp....sNVQslhLNPIIsQTARMpFTI+uG-GVaTLEhLpAGIEISGIQpPlDs....TouaNWos...GDsLPsKlGDKpupVplPupphpTsA-GoLsG-TGVLPTDsRSTPVuVLlNltVNGVPTQYphLlsGpaLLsGHSYNYTsTVKIcsG.ITVlTWQNpSWTsDI-	..DRVRIDPVAGGYYPSIS....PSAQTRGATPDG.ETLKD....RPIFLLEDGSTIRLVVYDDAKNLLEEYS...KAYLVRNAGTSGSSLLYPC.EVDD.NGAV.I..SS..SSTPLYMKAGTYYFRILSPAKALNSKGFVNIGNGEYLLATDDRYTQTAMTAVTITKIDEGGTLNNVQTLYLPPIINQTARMQFTVRAGEGVHTLEMLAEGIEISGIQQPLDN....TTSFDWVN...GDVLPVKVGDQSASVRIT..pATpNADNSLVAHTGVLPTDARSHSISVLLNLKVNGNPTQYQMLLTGLYLTAGHSYNYTATVKISNG.VTVLTWQNRSWTENV.V	0	0	1	2
+15270	PF15416	DUF4623		Domain of unknown function (DUF4623)	Coggill P	pcc	Jackhmmer:269656	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 470 amino acids in length. There are two conserved sequence motifs: HLL and RYL.	27.00	27.00	699.10	698.90	26.80	25.60	hmmbuild  -o /dev/null HMM SEED	442	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.66	0.70	-12.49	0.70	-6.11	6	9	2012-09-14 09:54:18	2012-09-14 10:54:18	1	1	9	0	2	9	5	445.00	55	94.19	NEW	-DYPtShs.uPY-T-LLSIKIlNAGssGspVVEGTIDE-sKpINFPRLDstTNFSAL+lEAcLSsGApLpppVhDhoM-EtsspKTlVLRVlNpsRYK-YhhKlRK+VPVaGADFEpPTVYsFS....GDs....lYssFsohLTRsAuFDGcaVLlVoRsss....tPHLLKVS-LKtGcIsPI.LDlTGVoGGTasYNMGALsNGHlYlASLSGups.SPLKIYYW-TPTSsPEVIAcINVusIPGAGsRHGDNhSlNLDcNGNGYIFFGDNAuoclLRlsluNaKols.s-spllPssscsshhoslaRltNTupYLaoGlchPloLlDpuhsspa...phs...ls...sEulAPRlhsFNpERYLIsCTAGpGuAoKAossLhVYDITKGsTlp-ALppF-pu-pHpPVYpFlLGGuGNsAPusQTsaYIEKDANGKDAKLhlFASRo-SGFVIsEFPlK.	-DYPcSh..uPYDT-LLuIKIlNAGssGspVVEGTIDEspKpINFPRLDstTNFSALplEAcLS-GApLpppVhDhoM-t-sspKTllLRllNpsRYK-YhhKVRK+VPVaGADFEcPTVYsFS....GDN....lYsDFs.sh.hTRCAuFDGcHVLlVoRsss....tPHLLKVSDLKtGcINPI.LDlTGVoGGTFsYNMGALsNGHlYlASLSGu+s.SPLKIYYWETPTSpPEVIAsINVusIPGAGsRHGDNhShNlDcNGNGaIFFGDNAAochLRlsluNaKTVs.spsplLPucscsshsoNlYRltNTspYLaSGlchPlTLlspuhsppa...p.s...ls...sEAVAPRlhsFNpERYLlsCTAGhGuASpAo.sL.VYDloKGsTlpEALc+FDpu-pHpPlYpFhLGGuGNGushsQTsaYIEKDtNGKDAKLhlFASRosSGFVIsEFPlK..	0	1	2	2
+15271	PF15417	DUF4624		Domain of unknown function (DUF4624)	Coggill P	pcc	JCSG:Target_390388-GS13780A	Family	This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 150 amino acids in length.	25.00	25.00	122.10	112.60	22.40	21.40	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.80	0.71	-10.48	0.71	-4.54	4	12	2012-09-14 09:57:47	2012-09-14 10:57:47	1	1	11	0	1	10	0	126.80	68	85.31	NEW	KsNtsphNsu-stEstpholEMEhstNYssSDPF.NuRLFCVScDl-sLsAEloFQMDG-pGIVEIKDpcoD-VLWSNsWcG+VsuDTaolSLsNLpK-KEYsVpFTGTKINHAlVcVSFESsLVpEKERPS	KoN-S+hNshsscEoupTTIEM-LDKNYDTSDPFVNuRLFCVSpDIDlL-sElSFpMDGDSGIVEIKDNKTDEsLWSNTW+GpVssDTFoISLsNlQKEKEYslpFTGhKINHAVVKVoFESsLV+EKE+PS.	0	1	1	1
+15272	PF15418	DUF4625		Domain of unknown function (DUF4625)	Coggill P	pcc	JCSG:Target_390125-GS13882B	Family	This family contains a likely bacterial Ig-like fold, suggesting it may be a family of lipoproteins.	27.00	27.00	27.00	27.00	26.90	26.50	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.81	0.71	-4.03	44	136	2012-10-03 16:25:20	2012-09-14 11:44:52	1	3	77	0	34	134	4	125.00	28	71.81	NEW	sSC.sc--..........Ds.pcPsIsht................PpssphhptGcs..lpFchploDsttLuuasl-IHpNF.DtHoHsspstts...............spsasappsa...........slststp.....shph+pcIsIPs-.....sssG-YHhhlplTDpsGpppht.shsIpIp	.........................s.uCsps-p......DsppP.hIphh.................pssphhphGsc..lHhc.hplss.sstlpshpl-I.......HsHstp...................stsasappsa...........shsstpp.....shpa+ccIsIPus.........sssGcYHhhlhlsDtsGspsh.hstslpl.........	0	19	30	34
+15273	PF15419	LNP1		Leukemia NUP98 fusion partner 1	Eberhardt RY	re3	Jackhmmer:A1A4G5	Family	This family of proteins includes leukemia NUP98 fusion partner 1, the gene encoding this protein is involved in a chromosomal translocation with the NUP98 locus in a form of T-cell acute lymphoblastic leukemia [1].	27.00	27.00	56.30	56.10	19.30	23.70	hmmbuild  -o /dev/null HMM SEED	177	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.76	0.71	-11.33	0.71	-4.18	12	48	2012-09-14 13:29:50	2012-09-14 14:29:50	1	2	25	0	18	37	0	150.80	60	94.99	NEW	DDDDV...SFAKWMSSFWGHSWh-EcE+tlRc+..+puQpsupR+sSLPCP...h..ssL.........P....................phhsS-ph...................PRRHS+EDQsFRs+sHh+shRcsSsDuSF+-PhcscsRSHS.IQcFSESFEQQLChRTKRSVSLuPEuRKERpEREsLRh.ch+S+KKscERRsS+KEEctEA.hssLhcK	.DDDDV...SFAKWMSSFWGHSWp-EcpRuLRc+..+psQssscRKsSLP..CP....h...shh..........P..............+h.SSDph.PRRHSHEDQcFRC+oHh+shRchStDuSF+-PhcscsRSHSKIpcFSESFEpQLCFRTKRSsSLGPEuRKERsEREpLRh.ch+S+KKscEcRsS+KEEcuEAhMusL.EK...	0	1	1	6
+15274	PF15420	Abhydrolase_9_N		Alpha/beta-hydrolase family N-terminus	Eberhardt R	re3	COGs (COG4425)	Family	This is the N-terminal transmembrane domain of a family of alpha/beta hydrolases which may function as lipases. The C-terminal domain (Pfam:PF10081) is the catalytic domain [1].	27.00	27.00	37.50	28.00	26.00	26.20	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.45	0.70	-11.14	0.70	-4.58	27	350	2012-09-14 14:16:58	2012-09-14 15:16:58	1	4	283	0	95	257	8	196.00	35	35.63	NEW	LTPSLlPRsalhQGlluGlshAlGYulGs......hhthlh+hhtlsphtshssp.....thphshsssssssslhhlh.ustWQsslpslMGhtshsshshhtsshlAllshssllhluRLlpthh+hlsthltRh..lPtcl...utslGlslllsLhhslssGVlhRthhpshspsapthsthhcsssstPppPt+SGSssSLlsW-sLGppGRsFVuuGP	............................................hTPSLlPRs.hhQullsGhstAhGYulGs.........hhhhlhc...hh.h......p.t....s.p...................................hhh.shhshsshhhlhhh.lhs.s....tWQcslpclhG.ls.phsh.h.shsl.sshlullshsshlhluRhltth.hR....hLsp.t.lpRh....ls.t..l...usslslslslsL.hlh.l.hNsVll.+tshsuhspshutsNs.psssspssPs.oPhRSGSPuSLhoW-u.LG+pGRsFVssGP..............	0	22	67	84
+15275	PF15421	Polysacc_deac_3		Putative polysaccharide deacetylase	Coggill P	pcc	JCSG:Target_416920-SP13771A	Family	\N	27.00	27.00	28.00	84.50	26.10	23.50	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.25	0.70	-12.26	0.70	-5.79	8	18	2012-10-03 16:37:10	2012-09-14 15:30:07	1	3	16	1	3	20	1	428.50	40	52.98	NEW	uEIsIshsssl.stsslslEIPPLKYNKchlhhhTQDDCp.AAashTWAAINGKPlosp................haacls.......HLptsDhP......PDhYhhs+sLusTDGsGpEVRFuhTsolus-...-pYMspcstlphGaTp-YaRFah+shlhWc-l+-hhNYGsuIAaHDVssh-h-ss.splht+aslupsl.Ihc+LsGRsCKhLuE.PNGs+sYlsAAhspDsIQTITAQuGs...hKlYPFpsstsLpK..sslpRhFhsss-.........h+psItcphu..pssE-RpAI..sIGsHs.......TDusWss...hLhWLNssYG+cGsDslWFPspEEYYEY.YhRpaopss.Kplspssl+LTVplPutcs..FYYPSlTlNLsGlp.h-hsSlpSs-sVTGLSYu......stcstlMlNlDCR+hLsEHAE+FVcpYEAs.ostus+ADAhYFVsMLK-SsKKstLhpRIp	..sEIsIchpssl.stptl.p..lEIPPLKYNKchlhhhTQDDChpuAashTWAAINGKPlSpp................haacls.......HLptsDLP......PshYshs+oLusTDGsGsEVRFuhTsTlus-...-paMspcohlp.GaTp-YaRFah+shLhWc-l+EhhNYGsuIAaHDlpsh-hcss.splhtcasluQsh.Ihc+LsGRsCKhLuE.PNGs+sYl....pAAhshDsIpTlTAQuGs...hKlYPFpsstsLpK..sslcRtFhsusc..........hKpsItc.hp...Ps.E-RpAI..sIGsHs.......TDspWss...FLhWLNcsYG+DG-DSlWFPopEEYYEY.YYRhpophs.KplsssolKLplpLPup.cs..FYYPSlTlNlpGlphh-IhSlpSs-sVTGLSYu......sacstlMlNIDCR+hLhEHAppFVcpYEAs.ost.s+ADAhYFVsMLK-SsKKstLhpRIp.....	0	2	2	3
+15276	PF15422	DUF4626		Domain of unknown function (DUF4626)	Eberhardt RY	re3	Jackhmmer:A1A4T8	Family	\N	27.00	27.00	57.80	57.70	25.60	22.10	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.36	0.71	-10.91	0.71	-4.22	3	11	2012-09-14 14:52:08	2012-09-14 15:52:08	1	1	8	0	2	6	0	102.50	74	87.51	NEW	MTGRMATLEKSHSSACWRKRSSRTCVEPDRTQDAIHEPRGLSRSHTVLRHRHFVFLPLSSGA+PSVPPR.....shhtscssGslphssPu.hhhhps.hhpthpphhh..hL....tKQhAcscsppPRuspSlhcsAD+LsW	hTGpMATLEKsHoSACWRKRSSRTCVEPDRTQDAlpEPRGLSRSHTVLpHRHFVFLPLSpGA+PSVPPR.....s.hh.c...............................................................h.	0	1	1	1
+15277	PF15423	FLYWCH_N		FLYWCH-type zinc finger-containing protein	Coggill P	pcc	Jackhmmer:Q96CP2	Family	This family is the N-terminus of some FLYWCH-zinc-finger proteins, found in eukaryotes. The family is found in association with Pfam:PF04500. There are two conserved sequence motifs: EQE and QEPS.	27.00	27.00	29.90	29.80	18.80	17.80	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.57	0.72	-10.40	0.72	-3.88	10	49	2012-09-14 15:06:59	2012-09-14 16:06:59	1	5	20	0	23	51	0	98.40	64	23.19	NEW	MPLPEPSEQEGESlKAGQEPS...scPGT-VVP..AAPRKPcEFScLVLLTsSpps.sDsssocPp-VHCVhSLEMuuPATLAs.TLQILPsEEQspllQPsPp.sEQK+SKlD	..MPLPEPSEQEGESVKAGQEPS...PcPGTDVVP..AAPR...K..PRcFSKLVLLTASpps.tcssGuK.ptVHClhSLthsGPATLAp.sL.hl.sEtQ.RslpsuPptPEQKRSK.D.....	0	2	2	2
+15278	PF15424	ODAM		Odontogenic ameloblast-associated family	Eberhardt RY	re3	Jackhmmer:A1E959	Family	\N	27.00	27.00	43.60	43.60	19.10	18.50	hmmbuild  -o /dev/null HMM SEED	264	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.86	0.70	-11.82	0.70	-4.90	12	37	2012-09-14 15:07:17	2012-09-14 16:07:17	1	1	24	0	16	27	0	246.60	65	94.37	NEW	APLIPQRLlSASNSNELLLNLNNuQLh....PLQlQ.GPhNSWIPPFoGlLQp.QQQAQIPGLoQFSLsoL-.pFAGLhPNQlsFPGQsuFAQGsQssQlDPSQ.QTPsQTQQGPspVMPYVhSFKhPQEQuQMhQYYPVYMLLPWEQs.QTsspSP.QTGp.Q.F...EEQlPhYspFGYIPQQsEPshPGGQQQhsFDP.hlGTAPEhAsMPsttVlPYLQKEhINF+HssAGlahPSTS..KPSTsshFTSulDP..TIsPchhEcKAKTDSL+EP	......APLIPQRLhSASNSNELLLNLNNuQLh....PLphQ.GPhNSWIPPFSGlLQQ...QQQAQIPGLoQFSLSsLD.pFAGLhPNQIPFPGQsSFAQGsQAGQhDPSQ.QTPsQTQ.GPs.p.VMPYVFSFKMPQEQuQMhQYYPVYMLLPWEQPQQTlspSP.QTtQ.Q.a....EEQlPFYsQFGYIPQ.AEPslPGGQQQLAFDP.hLGTAPEhAlMssGt.lPYLQKEsINF+HssAGlFhPSTS.sKPSTTNsFTSAlD...TITPcl.EcKsKTDuL+EP.....	0	1	1	2
+15279	PF15425	DUF4627		Domain of unknown function (DUF4627)	Coggill P	pcc	Jackhmmer:217257	Family	This family of proteins is found in bacteria. Proteins in this family are approximately 230 amino acids in length. There is a conserved WYK sequence motif.	21.80	21.80	23.80	23.40	20.30	19.20	hmmbuild  -o /dev/null HMM SEED	212	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.47	0.70	-11.64	0.70	-4.82	3	20	2012-09-14 15:08:15	2012-09-14 16:08:15	1	1	20	1	2	15	0	213.20	76	92.30	NEW	sGlpAQNLIKNscFD.T-LsTEhTsAspsTsG-WFAhNDEssGsTTISactTsDcK+GNAlcl..SussKssSWYKAFLGQRlpsGlEKGlYsLoFaAKAc-sGsQV+VFIR.....+ssNGKssspFFMRcsaDh..-SQPNpSuApYstsIKKA...GKWTKVolsFDFGKVVNAIuShKu..Ncst-VT-TDsssAhLKDFsIsIQ.SQoKsSsVLIDsVSLKK	....VSVSAQNLIKNEKFA.TEVKTKVTNANKATAGEWFIMNNEADGVTTIAWEpTGD..AKYPNAMKLDNSGAEKNlSWYKAFLGQRITDGL-KGIYVLTFYAKAKEAGTPVSVYIKQTNEEKNDNGKYNTTFFMRRDYDA..DAQPNASGAQYNFKIKDA...GKWTKVVVYYDMGQVVNAISSKKA..NANLEVSDTDDDAAILKDCYVAIL.SQNKGGVVEISDVTLKK.......................................	0	1	1	2
+15281	PF15427	S100PBPR		S100P-binding protein	Coggill P	pcc	Jackhmmer:Q96BU1	Family	S100PBPR is a family of proteins found in eukaryotes, and localised to cell nuclei where S100P is also present, and the two proteins co-immunoprecipitate. S100P is a member of the S100 family of calcium-binding proteins and there have been several recent reports of its over-expression in pancreatic ductal adenocarcinoma. In situ hybridisation shows S100PBPR transcripts to be found in islet cells but not duct cells of the healthy pancreas. An interaction between S100P and S100PBPR may be involved in early pancreatic cancer.	27.00	26.40	48.50	26.40	26.00	25.70	hmmbuild  -o /dev/null HMM SEED	386	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.46	0.70	-12.44	0.70	-5.39	9	68	2012-09-14 16:09:37	2012-09-14 17:09:37	1	3	29	0	29	67	0	252.40	51	84.12	NEW	NAPF.SWu..SL..DEDtLDDSLLELS-GEEDDGHFSaTEEEIpELLKDDD.SsEpp.ht..hhcDD..uscsEKGE+tSQILLDTPQEKNSLYSLGPsAETPulaKLPQLSTSlGHGPoPoKsLNR+FsLEKNLIKlT.V.APFsPTVCDslLDKDKTD....SSKDTEK.......sSSLGE-hRE-sLusNESKLCTESEsISPsNSAW-GPshsS.SNssFpQTVSDKNhP-SK+PTPVFSQI.DHSEoPs.su.Sh+NuGSHKSusEhR.PVVSSSSp.K.csLDKDSGKhKGpERRLGKVIPVLQsKsRTNVsTFSQS-LEQQKQIYL+sVIAHIEDPhDSNQGsLGELhALMDQV....HHMQN.+WQHPSDLTMRNYARFRQKPLQRYSLTQWVDRNhRSHHRFQRL	......................................................................................................................................ssh.SWs..o...DEDtLDDSLLEhS-GEEDDGchsaTEEEIp.LLK-D................t..st...p.Eht.+tSpIh.-sPpE.N..S.hSLGPsAETs.shhKLPQLsss.upt.......sR..s.EKshlKlT.V.sPFpshlhDshLsKcch-....SSK-hpp........usht-phpcts.t.sptp.hot....pst...........................................................p.stthp..hspospt.p..hhsh.....s.tp..........h.pp+hupl.sh...sttR......hSpspLEpp+.p.YlppVhtHlpp..t.pps..hEL.sLhsp.....h..p....p..hQHPSDhThRNY.h.ppp.h..hSLppW.......................................	0	1	3	6
+15283	PF15428	Imm14		Immunity protein 14	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with mostly all-beta fold and several conserved hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1 or Tox-HNH family [1]. The protein is also found heterogeneous polyimmunity loci.	23.30	23.30	23.30	23.40	23.10	22.90	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.59	0.71	-10.90	0.71	-3.74	70	172	2012-09-18 20:10:21	2012-09-18 22:06:20	1	3	152	0	38	165	2	121.50	18	51.88	NEW	..GDlFslsLs..sspauhGpll...shtths+............hhshhhsps.......p.hph.hpphp.shs..lcth.....hh..hhh.hcpshhpGc.....Wc.lIGppshtptptt........slhahh..shs................hpthp.h....sh...ph..p........t.....	........GslFshsl...tspauaGhll...shttht+............hhshhhshs.......p.hph.hsp.p.sl.s..lp.l...t.hh.sthh.hcphhhpGc.....a..IIGphshtptch.........sh.a.h..shs..............htthpth....s..ph..p......t..........................................	0	15	24	26
+15284	PF15429	DUF4628		Domain of unknown function (DUF4628)	Eberhardt RY	re3	Jackhmmer:A1L170	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 152 and 673 amino acids in length.	26.00	26.00	27.60	26.20	19.50	19.10	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.10	0.70	-12.04	0.70	-4.97	10	42	2012-09-19 13:37:54	2012-09-19 14:37:54	1	2	32	0	24	34	0	220.80	60	57.31	NEW	MFENhNsApsPKLQpS+ShspLo+ssususu.shGssEPuGPulhsGSSQHLK...NLGKAVGAKVNDFLRRKEPuuLGs.lGVhEVNKoAuApLuuusssspsshh....psctSh..EuFPRLDPPPPss+KRTPRALKTTQDMLISuQPVlSShEtuppsssupspco.spsps....sptsstpsE.ussppttpscsLsNG...................EsoL.SVPDLIHK........Dup--s+l+so-sR+uSoPs.hEpsGlKlSLS.hsLtE...psuuPsspuRTsSLDsEGPHPDLLSFE	.................MFEN.Nss.sPKLQtS+ShspLo+ssusssh.s.ussEPuGPulhsGSSQHLK...NLGKAhGAKVNDFLRRKEPouLGu.VGVhElNKTAuApLuuGscsssssh.....pscpSs.pEuFPRLDPPPPlT+KRTPRALKTTQDMLISSQPVLSShEhusp.ssupsp-o.stsps.......t....c.sshth.tpscsl.NG...................E.sL.SlPDLIHK........-sp-.shhp.sp.R+sSSss.hcp.uhK.SlS.hpLhE...psssss.tsRssSlDsEuPHPDLLSFE......................	0	3	5	10
+15285	PF15430	SVWC		Single domain von Willebrand factor type C	Coggill P	pcc	Jackhmmer:P0C5F3	Family	SVWC is a family of single-domain von Willebrand factor type C proteins from lower eukaryotes. The canonical pattern of most von Willebrand factor type C (VWC) domains is of ten cysteines, however this family, largely but not exclusively of arthropod proteins, contains only eight. SVWC family proteins respond to environmental challenges, such as bacterial infection and nutritional status. They also are involved in anti-viral immunity, and all of these functions seem linked to SVWC expression being induced by Dicer2.	27.00	27.00	27.30	27.30	26.70	26.70	hmmbuild  -o /dev/null HMM SEED	65	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.50	0.72	-10.59	0.72	-3.53	127	301	2012-09-19 13:48:04	2012-09-19 14:48:04	1	5	52	0	121	307	0	67.30	24	53.12	NEW	Ch..a.p..sp..hlss.Gtt.....hp.....pp..sCpphpCp.....pp..tplp..lpsCsth..s....st..sC...phtp...sssts.a.PpCC...phhC	........................C.hp..st...hltsGpp.....hp......ps...CtphpCp......pstplp..lpsCshh..s......sssC...chts.......shsts.a.PcCCs..phhC........	0	34	41	86
+15286	PF15431	TMEM190		Transmembrane protein 190	Coggill P	pcc	Jackhmmer:Q8WZ59	Family	\N	25.00	25.00	89.10	80.50	23.90	21.60	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.72	0.71	-4.23	3	18	2012-10-03 17:26:12	2012-09-19 14:49:08	1	1	17	0	10	16	0	125.60	72	76.72	NEW	GNGIQGFFYPWSCEGDVWDREACGGQAAIENPNLCLRLRCCYQEGICYHQRPDENMRKKHLWTLSLTCuGLLhLIFLICFFWWAKRRGLhKpLKMPGhLS+hKKsKlSRsVSpoSssphoLpcKcpSPLLus.sG	......GNGIQGFFYPWSCEGDVWDRESCGGQAAIEsPNLCLRLRCCYRDGVCYHQRPDENMRRKHMWALGWTCGGLLhLIsSICLFWWAKRRDh...LHhPGFLtG.+CD.LS+oVSLLSKcRGTtcp...........susss.......	0	1	1	1
+15287	PF15432	Sec-ASP3		Accessory Sec secretory system ASP3	Coggill P	pcc	Jackhmmer:Q9AET7	Family	Sec-ASP3 is family of bacterial proteins involved in the Sec secretory system. The family forms part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell-wall glycoprotein adhesin encoded upstream in the same operon.	27.00	27.00	39.30	39.30	26.00	21.80	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.00	0.71	-10.50	0.71	-4.18	38	390	2012-09-19 13:50:34	2012-09-19 14:50:34	1	2	375	0	22	205	2	123.30	46	50.80	NEW	oYhYGSplpapspspVpFpNsLhPSGphI+sWtStsNaQu.sRtsPsLPLL++GppYclphsh-sp..Ppsulal+lhFaD+hscplpphlh+spp..hpFsYPccAYsYpIpLlsAGhpplsF+plpIp-hp	......TaMYGSpVsaps.scVpFhNPLMPSGhsIHpWh.hppFpp..h+.osPsLPlL+RGpcYpLphsF-sp..PtsoVYhhIhFas+pupcLuppIlKsps..hshpYP-EAYuYclphhsAuspSLhF+sloIpEh.s.......	0	7	8	18
+15288	PF15433	MRP-S31		Mitochondrial 28S ribosomal protein S31	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q92665	Family	MRP-S31 is the mitochondrial 28S ribosomal subunit S31. This family of proteins is found in eukaryotes. Proteins in this family are typically between 246 and 395 amino acids in length. There are two conserved sequence motifs: RHFMELV and GLSKN.	27.00	27.00	30.40	30.40	20.30	25.20	hmmbuild  -o /dev/null HMM SEED	298	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.28	0.70	-12.18	0.70	-4.99	29	122	2012-09-19 13:52:14	2012-09-19 14:52:14	1	6	87	0	76	120	0	254.30	40	76.53	NEW	spccLhslltuMKl-.lssp......p.h......pps.c..tpp.h.cshpsssuhhp+spp-us...p.ps-slss-LlsAApsVAsoLs...s-+p.pTESELLppLhpHcspspspppt....................pppcls.......hu.slIusMK.......ls+ssst+...hss...................Rssp...pIpFc-p.tcshs....pcc........c.stsh+p..........chsLFsG+pLsIFssts....cpsspstst.olW-h.ht+pLuhsspQPPtNtFEEMIQWTcpGKLWcFPIsNEtGh--E.ss.cFpEHIFL-+HLE.sa.P+pGPIRHFMELVssGLSKNPYLoVcpKhEHItWFR-YFppKcDlLKEs	.........................................................................................................................................................................s...................................................tt...t.t.hpct.t.t.......tc..shs.plltAspslAs.Ls.....cpp.p...scSELLtpL.t+pptststttt.............................................................................tt.ph..p.......hp.pll.sshK.......ls+ptt.p....t.........................................p.p........p.phcpt.pt......tpc...................p.t.hpp.....................................phslap..u..c...Ls..IFp.tt.....t.....s.st.shWsh..t+...pLsh.hs.........p.ps..s.tNtFEEhIpWTcpGKlWcFPIsNEt.Gh---.ss.pFpEHlFL-cHLE..sa...P+pGPIRHFMELVssGLSKNPYloVppKh-HItWFRsYFppKc-lLp-...........................	0	27	33	55
+15289	PF15434	FAM104		Family 104	Coggill P	pcc	Jackhmmer:Q969W3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 113 and 185 amino acids in length. There is a conserved SLQ sequence motif.	27.00	27.00	43.40	43.30	25.20	25.10	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.85	0.72	-10.57	0.72	-3.86	10	68	2012-09-19 13:53:57	2012-09-19 14:53:57	1	1	32	0	30	93	0	113.20	66	80.69	NEW	RKRRR............sGsEEDsalsPQsKRss......+NslhQDsaDTE.....................SSSSDstp.......SSSuINSP-RA...........SG...PEsSLNQhssssusNh.PQ.hp.EpSAlC..QGPYsHINQlLKEAHFaSLQpRGRP.PT	........................RKRRR.NGsEEDNHlsPQoKRSS......RNPlFQDSWDTE.....................SSuSDSGG......SSSSSINSPDRA..............SG...PEuSLsphhsGSuPNT.PQsh..EQSALC..QGsYFHINQTLKEAHFHSLQHRGRPsT....	0	2	4	9
+15290	PF15435	UNC119_bdg		UNC119-binding protein C5orf30 homologue	Coggill P	pcc	Jackhmmer:Q96GV9	Family	UNC119_bdg is a family of eukaryotic proteins that probably plays a role in trafficking of proteins, via interaction with unc119 family cargo adapters. The family may play a role in ciliary membrane localisation.	27.00	27.00	221.20	221.00	18.30	17.10	hmmbuild  -o /dev/null HMM SEED	197	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.26	0.71	-4.96	5	39	2012-09-19 13:59:18	2012-09-19 14:59:18	1	1	37	0	25	31	0	196.10	83	95.14	NEW	MDINGsSRoslSlLP..AAElpSTLKPEAEKPRCSSTPCSPIRuTVSGYQILHMDSNYLVGFTTGEELLKLAQKWSsG-ssKu...EAhPS....slsKsVDlGLHRSSRIYKuKSRYYQPYDIPAVNGRRRRRMPSSGDoCpKSl.Pa.EPtKALHGPLPLCLLKGKRAaSKSLDYLNLDKMsIKESuDTEVLQYQLQHLTLRGERV	.........VDINGESRSsLoTL..PhPsAEssSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEESKG...E.Ah.Po....LRSKQLDuGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKSL.PY.EPYK....ALHGPLPLCLLKGKRAHSKSLDYLNLDKMsIKEPADTEVLQYQLQHLTLRGDRV	0	1	3	10
+15291	PF15436	PGBA_N		Plasminogen-binding protein pgbA N-terminal	Coggill P	pcc	Jackhmmer:O25249	Family	PGBA_N is an N-terminal family of bacterial proteins that bind plasminogen. This activity was identified in In Helicobacter pylori where it is thought to contribute to the virulence of this bacterium. Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a Pg activator.	27.00	27.00	69.90	69.60	23.00	22.10	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.61	0.70	-11.48	0.70	-5.07	27	196	2012-09-19 14:39:47	2012-09-19 15:39:47	1	5	194	0	21	117	2	213.50	51	74.30	NEW	hpslcsslhtV-stt.sh.lphpu.clpVGpSGhVlpph.ss.pssIlApAsVhph..p..sGhApl+apsF-sLpQcALPpPphhPptGDcllLsahYsRullIAPsp-hYpplpssas.slpFlHsDlhuuaL...ss....sPp+cDF++hCst.ulGLlalshssch.hlDCpSFplLp.pphs.ts.spphphPFYSRlpsI-sshas......hsu.pchpsY.sYYcpLl	....................l.+PlKscLlcVDDhh..Ga.I+.DSsDIKlsSSGVVlp+F.ssspSIIARAuVIsK..c..sGlAKLcFoVFsuLKQ-ALPLPsllP+tGDEVVLNFLYDRuLlIAPD-pTYsclstsFP.pIhFsH.DlhGApLhhsss.h.uPKRuDFRcFCs-sAVGlLhlAL-NpupllDCQsFshL..hEls.lScsossQlPFYSRIuGh+osFFD......FNS.pclsNYYcYYDALl...................	0	5	17	21
+15292	PF15437	PGBA_C		Plasminogen-binding protein pgbA C-terminal	Coggill P	pcc	Jackhmmer:O25249	Family	PGBA_C is an C-terminal family of bacterial proteins that bind plasminogen. This activity was identified in Helicobacter pylori where it is thought to contribute to the virulence of this bacterium.  Both PgbA and PgbB are surface-exposed proteins that mediate binding to plasminogen such that it can be converted into plasmin in the presence of a plasminogen activator.	25.00	25.00	27.10	25.60	21.50	20.60	hmmbuild  -o /dev/null HMM SEED	86	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.31	0.72	-3.85	7	118	2012-09-19 15:07:48	2012-09-19 16:07:48	1	5	44	0	3	126	0	85.50	60	25.41	NEW	hcEssspsNuo.....ppptpcN.....APs.KEsNA.KEtsKLssKEEKRRLKEEKKKAKAEQRAREFEQRAREHQERDEKELEERRKALEhNKK	.................................t......ppspts.....ppptscN.....APs.cEsNspKtEpKLsuKEEKRRLKEEKKKAKAEQRAREFEQRAKEHQERDEKELEERRKALEhsKK....	0	3	3	3
+15293	PF15438	Phyto-Amp		Antigenic membrane protein of phytoplasma	Coggill P	pcc	Jackhmmer:Q7M1T6	Family	Phyto-Amp is a family of phytopathogenic wall-less bacterial antigenic membrane proteins [1]. The bacteria are limited to the phloem and pose a major threat to agriculture worldwide. They are transmitted in a persistent, propagative manner by phloem-sucking Hemipteran insects. Phytoplasma membrane proteins are in direct contact with hosts and are assumed to be involved in determining vector specificity. Phyto-Amp is thought to be one family of proteins that mediates such specificity. The proteins appear to be encoded by circular extrachromosomal elements, at least one of which is a plasmid [2].	27.00	27.00	48.60	47.80	21.50	20.40	hmmbuild  -o /dev/null HMM SEED	195	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.77	0.71	-11.26	0.71	-4.67	3	24	2012-09-19 15:22:09	2012-09-19 16:22:09	1	1	22	0	3	23	0	179.30	70	82.31	NEW	MQNQKTQKSLVAKVLVLFAAVALMFVGVQVFADsPLDLSTLcC-ssLELTANDASDAEKVVsQWKVQNTSLDKKVTKDSVKVtVADNKVTVTPVDuSATSALoGSKVLoLVGVCELNKLTLGTDKKLTLTVKDDKVDAEAGLKALKEAGAKVPATVTKDDLTFTVGKGDDANKVTVKAVDGKTTVSGQVTFEFNV	MQNQKsQKSLVAKVLVLFA...AVALMFVGVQVFA.DDKLDLuTLEC.KssLELTAA.DAuDAEKVVKQWKV..QNT..SLsAKVTKDSVKVsV....AD.NKVTVTPADuDAuKALoGSKlLsLVGVCELNKLTLGTDKKLTLTVKDsKVDAEAGLKALKEAGAKVPATVsKDDlTFTVGKsDsANKVTVKAVDGKTTVSGpVsFEFsV......	0	1	1	2
+15294	PF15439	NYAP_N		Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter	Coggill P	pcc	Jackhmmer:Q6ZVC0	Family	NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8 [1]. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice [2].	27.00	27.00	137.40	34.80	20.80	19.70	hmmbuild  -o /dev/null HMM SEED	379	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.86	0.70	-5.28	20	174	2012-09-19 15:53:14	2012-09-19 16:53:14	1	16	37	0	86	128	0	321.70	41	37.94	NEW	AREsDRlRschstshhpcphp.t...stpp-........ssK.tp-tsuht.............RHFR...ushshPhu.Dplsps......su.u.uhRS.SLHSVhSh.D-uuuhs...........SsRKQPPPKPKRDPsTRLSAShEA...........Vu..AsLss......usKcuupt.....hs+PRPHS...D-..ohKKIPP.KPKRSPNT+LSuSaEElsuts...P...u.....spsu.ss...........sht.ph.spsspsssp....................pp.cs.E-EPVYIEMVGssh+stu.........................scuss-puEAVYEEMKY.hs.E-ss..sts...shssuS.Pshpsp..p.hs..h...psth.sttpus..ppssCDIPsPFPNLLsHRPPLLVFPPsPsTCSPsSDESPLTPLEVpKLPVLEs.............s.pashQssuSSP.Ss.Qhstsp.Kusss....Psus.shsshss..usRspSpuTPhP.Pp	...........................................................................t+Ep-thRpp.p.sh.tt..t.....th.t...........sh+.ht..-.tsht.............+Hh+h..u.hohPs.s.-p....h.....sps...........ss.u.usRS.Sh..HSVtuh.Dss.uuhs...........tsp+.pPPsKP+RcPsT+LShS.cs........................................ss..uphss...................................spptssp..........+PpPcu...c-....+KlPP.KPKRsPNTpLSsSa-E.hh.t.......s.........stt...s...sh...........sht.t.....upsss........................sp--EPVYIEMVGshhRsht..........................tpps-puE.ulYEEMKYsl..--hs.......t....s..t...hss...........sS.....s.p.p..................s.h.t...ss..pt..C-IPPPFPNLL.HRPPLLsFPsusspsSssuDpsPlsPlpVp+LPVLp..............s.pa.c.pssuuoP.u......phstppptps.........tsshhh.ss....ssps.opusP.Ps.s.........................................	0	3	11	30
+15295	PF15440	THRAP3_BCLAF1		THRAP3/BCLAF1 family	Eberhardt RY	re3	Jackhmmer:A2AJT9	Family	This family includes thyroid hormone receptor-associated protein 3 (THRAP3), which is a spliceosome component and a subunit of the TRAP complex which plays a role in pre-mRNA splicing and in mRNA decay [1]. It also includes the transcriptional repressor Bcl-2-associated transcription factor 1 (BCLAF1) [2].	27.00	27.00	27.30	27.30	25.60	25.60	hmmbuild  -o /dev/null HMM SEED	646	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.67	0.70	-13.46	0.70	-5.86	22	245	2012-09-20 09:01:36	2012-09-20 10:01:36	1	8	42	0	94	181	0	501.30	34	75.82	NEW	uRSRSRSP..K+RSh.SPtsR.spp+..acp+pSps+h.ssp.......R.....+csppss.phR.hcs-K.pspscp+hssctsst..h+ph..E..c+ususshc.tsh-shhs.ps.p..................p.sh.Pt...tsD.sspRuph.Pphsps.sshccppps.......shs.psps+hh.sshp.ptstpst+ssp.........RSh......usS......+apsp............h+.........psphc.tpph..pppphspS..+cu....s--hpsRoSFpK..RYP..E..Dp-hcphs+ppcRsp..DhE+h.........c.....s+cssR.....ssch......c.cc.uhss...hp-cc...cphshu.psc.RhstR-h.-p.....ups..sK......ohDYc+K++p.hs..cs-pcFsDs........csp+hsccEDpKappptt...s.hs.+.EussFs......ssRsccoc-tps........+c.s.K...scKcshsps....p..ssps-lchcssppKhcp+hc..pp....shR+p.ssspppphspspch..sthKsSssph+c.....cplslKlDst..shDphR..suuShssERphu+DLVtsu+KpppF+slF-HlcS.sQs.pppPotpFsQcIlTIlHpVKtpYFsSsshTLpERFo+hp...css..p-s.+pppsPEIHRRIDhS.upLpp+pph......hpE.......oppshhK........h...DPsDLRHDIERRRKcRhpsc-c+thp......hsSuspRspppS..phpph.ps.cs-tFpKss+hh.+.sphRph.ppPpps........oppppcshpp...ctathcsppcs..cp..ppsFc	..................................................................................................uRSRSRSP..K+RS..S.tsR.spp+..p..+pS.....p..s....ppp.....p.......sp.ss.p.R.hpppK.ptptt.t.........s.ptps....tsh.p...ppt.psp.p..s.ts..php..p..................t.t..st.....ths.sp.pu....s..tt..s.pppp.p.......s.s....s.....s..s..p.t..tsh..tts..p....................puh..................ttu.................phpsp......................p............ps.hp....h..p.tph.ts..pt..............pt.tttuua.........Y...-.....-pcht.......phtch.p+.p..-..cp..................p+tshp.....p.th......................t.c.s.........tc.pp...ths..st+.t..+p.t..pp......sph..tc........p...D.pphcp.t..hh...tpptc...st.............t..p..s.tts.+.p.t.t..........hp.h.E..hht..........ptct.chpp.t.....................tt+pp.t.tt....p..s....h..ph..........ph.......st........c.p..p.......hp...s.s.pp.h....s.ttp.....s.hc....S......h+..........tp.pV+...hc.h..s.D..p...............su..hsp-R.hspsLVtss+Kpp.pF+slFpHlp..sQs.ppssSc.FhQcIlollH.pVK...tpaF.SsshTLpERFoph.......+usppc...p.ppsPEIHR..R.IDl.S.ushpp+.thh......htE........ppts.K.............h.tDssDLRhDI-RR+K....c+.pp...cp.hp......htSs.s...pRppppo..p.pp......cscthpK..p...p...........tp...s...........p..................................................................................	0	3	12	34
+15296	PF15441	ARHGEF5_35		Rho guanine nucleotide exchange factor 5/35	Eberhardt RY	re3	Jackhmmer:A5YM69	Family	This family includes Rho guanine nucleotide exchange factor 5 [1] and Rho guanine nucleotide exchange factor 35.	27.00	27.00	69.70	36.70	23.10	18.80	hmmbuild  -o /dev/null HMM SEED	487	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.14	0.70	-12.70	0.70	-5.69	11	32	2012-09-20 09:25:48	2012-09-20 10:25:48	1	5	22	0	18	32	0	418.10	51	33.63	NEW	MEAEEPpHGASTPlPAlcEhullPEulMRSSQIPAL-PEAQEGpDPSapWsEGHRLltsQp+-LRDssDaAs-Shs.FPK.EuSsssEosQEsLVAEAsD.TPEpQEuVsQSLsDcpARTlAsPEhhACPlQuEaLDh.sshSocLsoR.VEsEhpPELTSLsLusupA-E..cEEsSPssSspstaaPsCc.cHPuETsps.csutussl+QGEcLQhctsQES...p...G...L...LpPQEAQGLEEQttQEsthQtEGTlpEslCsDGLhGE.p.QhsEp.ssGsEtEQ+QKQEQlQ.D.sh.LG+QGEppGLs..GELEGLssuEhs.EppEpcspspcssEptEppcpEhpuPEEpcssoQstEsQSLlEKSEcVotKQEscGlp...GcshsVEGQE.......E.......EEPGsWDuushushscppsspEpcE+cGPSsL.AhVAPEVsSPsDLFP-sShPhopIPGTQpEP..tAEELSPtALsPsLEPscWSaQPlS.PuSFPstESLDscT	..MEAEEsQHGASsPIsAltEhSlIPEA.MRSSQlsALs.EAQEscDPSYKWpEtHRL.tTQQp-LRDVsDaAhEoMsSFPK.EuSu-VEssQEslVAEssD.TPEp.EAsPQSLAsRQARTlAsPELhACPlQuE+LDh.sshSS-LGSc...EVEFhPtLTSLsLGouQAEE..cEEoSsDsSuQTpaassC-.-HPsETsQs.csutSGolRQGEEL..c-hQESp...GLlpP..QEsQsLEEQGpQE.sshptEGTLtEslCuDGLLGE.p..QMhEQ.lNspcGEQ+QKQEQlQ.DshLG+QGER.tLs..sE.EGLNsuEhtpEphEpcspsQts.cptEtpcpEhphPEEpcssuQspcsQ.ohhtKSEcVotKQEspGhp...tcshslpsQE.t.......cE.tshDusthss.s..ttpstEEtpEHcGPsh..s.lAPEsss.sDlFPsssh..ho.pI..PtTQpEs..pAEELoPtA.sPsLEPhthSaQPhS..uSFsstES.DpE..........................................................................	0	2	2	3
+15297	PF15442	DUF4629		Domain of unknown function (DUF4629)	Eberhardt RY	re3	Jackhmmer:A6NCI8	Family	This domain family is found in eukaryotes, and is approximately 150 amino acids in length. There are two conserved sequence motifs: MHML and LGKK.	27.00	27.00	44.60	42.40	19.10	18.20	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-10.96	0.71	-4.08	26	89	2012-09-20 12:35:51	2012-09-20 13:35:51	1	2	25	0	50	72	0	142.30	49	19.49	NEW	usS-psRKNKHKASE.lsuAPcAKIQscs.-sLltGEss.lssAsuS-+AstshAK+pssKs.KsAsuRss..ps+upGQ-+s++spENsoKKstEpKQSss+V.KAEEKPsIPKpKRK+s.PELSQEsFKKPRosLGMHMLESVQVFHsLGKKs	..........s.SDQsRKsKHKASEPlpGAPcAKIQscss-sLltGEss.lssAsuS-+AssNhAK+sssKspKuAuSRss...psKupGQE+sKpsp-NsSKKspEpKQSss+V.KuEEKssIPphKRK+s.PELoQEoFKKPRosLGMHMLESVQVFHsLGKK..........................	0	1	1	5
+15298	PF15443	DUF4630		Domain of unknown function (DUF4630)	Eberhardt RY	re3	Jackhmmer:A6NCS6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 124 and 286 amino acids in length.	25.00	25.00	25.50	25.50	24.00	24.40	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.71	0.71	-10.98	0.71	-4.41	6	29	2012-09-20 12:49:22	2012-09-20 13:49:22	1	1	25	0	18	23	0	138.90	47	63.95	NEW	GA..ALVGVLVAEAuPEDAVAP....tLRLLEALLRsVFGRQAGG....PVQAAAYsPGpPA.SSLAVQsAACRALQAAGPu+PAEGAWERPGLPuLLACFSWGPWS.RtKs.ssous.suPsQschQ-sEEELALTulaPNGDCED.sG+GStApDGlsp.sPs-PsGDo	....................................hlGlhhh.st.c-u.su........tlplLEuLLRsVF..G+psGG....sVQAAsYsPGpPA.SsLuVQtAACRALQAAGsucPs-u..AhERPuLPuLLsCFSWGPhp..++Kspsssus.psPup-shQ-sEEELALTul.aPNGDCED.hGpGocApDGshH.sPs-PsG-................	0	1	1	5
+15299	PF15444	TMEM247		Transmembrane protein 247	Eberhardt RY	re3	Jackhmmer:A6NEH6	Family	This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 197 and 222 amino acids in length. The function of this family is unknown.	27.00	27.00	30.50	30.40	22.00	22.00	hmmbuild  -o /dev/null HMM SEED	218	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.75	0.70	-11.58	0.70	-4.52	7	30	2012-09-20 13:25:11	2012-09-20 14:25:11	1	2	23	0	16	41	0	198.90	71	95.41	NEW	MAsEDREhMEuRGAGESCPThPKhVPsDshsEGKP+ApLEAEs.KPDSSYDaLEEhtsCEDGuCsGPPK........s.sstuuPs.TKGQAGDGP..EssELsh........sPGsEHssEMELEKlRMEFELTRLKYLHEENERQRQHEpVMEQLQ.....pQAss................FSGGLQDLLLPQNQFAMFLYCFIFIHIIYVTKEMlFFLFSKHYLFCIAAILLCLIKTLWS	..........MAsEDREMMEARGAGESCPTFPKhVPuDshSEGKPRAsL...EAES.KPDSSYDaLE..EMEsCEDGGCsGPsK........SLSsKusPs.TKGQAGDGP..cs.uELP.........sPGT...E+.NsEMELEKVRMEFELTRLKYLHEENERQRQHE.VMEQLQ....pptp.....p....l.p......h.s..FSGGLQDLLLPQNQFAMFLYCFIFIHIIYVTKEMVFFLFoKHYLFCIAAILLCLIKThWS............	0	1	1	2
+15300	PF15445	ATS		acidic terminal segments, variant surface antigen of PfEMP1	Rask T, Coggill P	pcc	Rask T, [1]	Domain	ATS is the intracellular and relatively conserved acidic terminal segment of the Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) [1]. this domain appears to be present in all variants of the highly polymorphic PfEMP1 proteins.	27.00	27.00	29.60	29.10	21.30	20.80	hmmbuild  -o /dev/null HMM SEED	437	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.73	0.70	-12.78	0.70	-5.37	35	168	2012-09-20 15:35:02	2012-09-20 16:35:02	1	33	2	0	22	173	0	348.00	56	19.28	NEW	STlsaulGluhuohsahaLK...KKTKosV.sLFplLpIPKuDYsIPThKSsNRYIPYsSs+YKGKTYIYMEGD....ouuD-.KYsh.scooDIT.SSESEYEElDINDIYVPuSPKYKTLIEVVLEP.................................o.p........sTQNDIssDsl.PSs..................lTDsEWNpLKcDF......ISphLQsp..Ns.P.pshhssslshNTpP..Th.ccsh............EKPF......IhSIH.......DRNLYoGEE....YoYNl....sM........STNohs............D.shsssN..........................sl.......YSGIDLINDoL..Gsp.lDIYDElLKRKENE....LFGT.NHsKp.TSspSVAKpT.sSDPIhNQLsLFHKWLDRH...........RDMCEKW...NNKEElL-KLKEEWpp-sp........SuNh............................................................spN......................+sLNTDVSIQIcMDNPKPhNEF............oshDo.sptssMDoI..L-DLEK.aNEPYa...hpDD.IYYDVNs-cssosps...................................hspNs.hDV...PoKVpIEMcl.s..p..cllcEcYPIuDVWsI	........................................Tl.aululuhu.uhsahalK..KKs.KosV.sLhpllpIPKuDYsIPThhSsNRYIPYsSspY+GKpYIYhEGD....pusDp.tYh..schoDIT.SSESEYEEhDINDIYsPtuPKYKTLIEVVLEP.................................o.s...........c.T.p.NDI.sDsh.Pos.................phTDsEWNpLKc-F......ISphLQsp..ps.P..shhpssls.NTps..Th.hcs..............-EKPF......IhSIH.......DRsLYoGEE...hsYsh.............sNs.p...........................p..h.tpN....................................YSGIDLINDsL.sGs..hDIYDEhLKRKENE......LFGT.pasKp......To.psVuK.s.psDPIhN.QlpLhHp.WLD....RH...........RsMCEpa...pscp-hLsKLpEpWpp-sp.............ussh..................................................stN.........psLNTDVSIpIcMDpsKshpph............o.........sMDshhps.hc..................sD.IYaDVp.p.t..........................................spN..h-h...PpKlplEMpl.s.......t.hc.paPI..........................	0	22	22	22
+15301	PF15446	zf-PHD-like		PHD/FYVE-zinc-finger like domain	Wood V, Coggill P	pcc	Pfam-B_5236 (release 26.0)	Domain	This family appears to be a combination domain of several consecutive zinc-binding regions.	27.00	27.00	27.20	27.80	26.20	25.70	hmmbuild  -o /dev/null HMM SEED	175	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.84	0.71	-11.46	0.71	-4.98	28	70	2012-10-03 17:27:21	2012-09-20 16:37:26	1	6	70	0	57	73	0	166.90	44	10.80	NEW	sCcoC...usstp+G..sLlaCQGCosSYHKsCLGsRSsR-HhVTKVGs-sFVLQCRhClGlh+cKDstAP+putCpsC+ppGhuCtPFpp+pTs+QEpplR--NuGsDPITsV-ssL..lNNs-NVLFRCs....pC+RuWHhcHLPshup.s.sssssps..........p.h..pppRhcEYShcWpC+-Ct	.................................CcsC...uss.p.+G..sLlaCQGCosuYHpsCLGsRusR-HLVTKVup...-pFVLQCRhClGhs+pKDspAP+putCptCpp.Gt..hscPh.Rp+hTs+QEpplR--NuGtDPITsV-.sL..lNN.....s-NV.....LFRCs....sC+RuWH.hcHLPshspss.t....t.p.p...........p.htppRhpEYohcWpCc-C..........................................	0	10	27	45
+15302	PF15447	NTS		N-terminal segments of PfEMP1	Rask T, Coggill P	pcc	Rask T, [1]	Domain	NTS, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors [1]. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1α1), shows this region is directly implicated in rosetting.  NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1α domain that is found to be the important heparin-binding site [2]. This family is closely associated with PFEMP, Pfam:PF03011, and Duffy_binding, Pfam:PF05424.	25.00	25.00	25.40	25.20	22.90	22.00	hmmbuild  -o /dev/null HMM SEED	37	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.23	0.72	-7.49	0.72	-3.56	205	318	2012-09-24 07:58:16	2012-09-20 17:12:31	1	36	2	2	14	324	0	37.30	39	3.36	NEW	sAKclLDpIGcpVa.cc.l+...p.........c.....A..cpY.ps.pLKGsLspApa	..SA+slL-pIGcplpcc.scp.........c....A....ppY.pspLKGsLopApF..	0	14	14	14
+15303	PF15448	NTS_2		N-terminal segments of P. falciparum erythrocyte membrane protein	Rask T, Coggill P	pcc	Rask T, [1]	Domain	NTS_2 is a family of the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) [1]. However, in this group of proteins conservation is high. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors.	25.00	25.00	29.60	98.10	22.50	17.90	hmmbuild  -o /dev/null HMM SEED	51	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.11	0.72	-8.60	0.72	-3.67	6	14	2012-09-20 16:26:11	2012-09-20 17:26:11	1	6	2	0	0	16	0	50.70	79	1.93	NEW	MDSKoTIAsKIEAYLccKSs-ScIDQSLKADPSEV-YYsSGGDG.YL+pNI	MDSKoTIA-KIEAYLttKSsDSKIDQSLKADPSEVpYYpSGGDG.YLKNNI	0	0	0	0
+15304	PF15449	Retinal		Retinal protein	Eberhardt RY	re3	Jackhmmer:A6NGG8	Family	This family of proteins is found in the photoreceptor cells of the retina [1,2]. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy [1-4]. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina [2-3].	27.00	27.00	60.30	40.20	17.70	26.80	hmmbuild  -o /dev/null HMM SEED	1287	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.27	0.70	-14.14	0.70	-6.91	14	48	2012-09-21 07:43:49	2012-09-21 08:43:49	1	4	32	0	29	36	0	990.40	43	96.82	NEW	MGCTPSHSDIVNSVAKSGIQFhKKPKAILPG+QusSE+sSIPLLVpSSTCaDsGtshptG.......pc.tpEpPus+hsQosucuhpQhstsPhsuptKDhEGhhPEscoo.SQLscSQSHhAcDlsh+TQuSHtoQGuuFuG-EucEssoQcoSpht+KP+CHpsucQ.GHs..sQT....hhPAhtscuKVDFPEPLVKAHQ+AYsYLHosLSKYEAILplscQAoQTpELLQPMVoFLLLCF-ElNQLLGEISKDGEsLLQEV+tDLAWP.+KGEPpEQPDLLQQLLQYTVuKLQlLpGTVAoLTuShLEGSuSYLposASHL-sKLSsKRGhDE+LLRALGQLESLASGHuDPGlpshPLCSEDSGIGADNESVpsl...DKLGKQuSWDhssEPuEWKsshsP.psEA+hsGpuWQpuPahhGuDRPQDCPLSRPhtAKlQPAAQGpAsssssSuouPEssoo.RPhthuKSssp....-Shusssss-A+hsKu.StlhsoPSLSEsEDSSsE.E.-ED-huuhs.sshpcpss.sRPpSSPAssESsFQP+s+RLRSPQAQEMILKMKEAISERIKFVPVPSu+QDWAEE.EEt+ThVssRPSTsSGSRRAPtRQRRSQSEuCLKSasEDPTLQELRRVQ+DLSQRLEsFYALGs+pQGQu........pEplL.PRAAs.LhP-sssRVsPSoTISKLKASLTKNFSILPSQDKSILQ+ssPpP.......EuEps.Q...scAEtLPss...hPsuE+......s.EA......PGspDhssRGCPTRTSVKKLIETFSPsEuLRT.GDS+ssGsSPCLRKWGlPIMPPRFPIYRGLAPLYPKPQISPAuGp-sLphG.uWRPhAPhFPPL.sAEAscs-D..h..ssEs-ED.EcLPPPPLEILMDKSFsSLEsPESSpsuGSSsEsTtsPGLupssss.+RTWASPKLRASMSPhDLLPSKsssoPsRspuTGPGsoKsssssRKLsLDLsp...sPAsutsPEsEu...tu...Q..sp..A-+AsSLuKpPpKAlPWHHsSpTSGQs.RTpEPSlARPopGP.....+SPEAs......RpopERSPsllRKASPTRuH.WsPpuD+Rp.S.PSoHRP........AQPSlPsVpuSP....SPPl.........SP....Rs............hSPPss++hsSPPsp+KhPSPP...s.............huSPPsQ+sEAuSPuSuPSsSPPsSPSQGpK-sp...cS.EDupuusu+suuNTpSIFCPATSSLFEA+...sP.Sss+PhoP....PEuGGshtpPsGsWRuSuGPRhRu-SQRpsuLCALNPQPFlRRTASDRpP....Gs..+LpLP.usuhsupsspsthSpSSS.S.EESPKK-sEPWsuPsuPEL+G.uuRtASPPELCVLGHGLQ	.......................................MGCoPSHotIlpolA+sGlphh+KPKslhss.ttss-+hslPLLspsSohhs.st................ppt..t.ph..thtps...........ptcthpt..stsps...ph.cuQp+hscch.h+pQuSptoptsshss-pspEpsspt....t+p.+spppupQ.s+h...pT.....hss.tsctKVDFPEsLVKAHQpAYsYLHssLSKYEAILplhcQAoQTp.lLQsMloFLlLpF-ElspLLtEIucDGEhLLpEVttcLAWP.pKt-spEQ..............PDLLQQLLQYTVsKhQhLpuTVAsLTuohLEsSsuYLposAs+LppKLpsKRshDEpLL+sLupLEuhAsupucPthpshPLpSEDSGIGADNESlpth...DKLG+QsSaD.ssc...phc.hhts.phEst...psWppsPhhhu.tpspDs.Lpt..hshhpPtspststsss.S..shsstshss..shthtpStst....sShshshshcsch.cs.st.hsssShs-sEDSos-.E..--p.ushs.p..pcpt...RPpSSPAsh-usapsps+Rlcu.QApEMILKMK-AISE+IKFVPs.sspp-WsEE.E-tpshlssRPSTssG..up+sst+Q+RSpSEtsLpSpsEDPTL.ELpRlQ+DLSp+LEhFYshst.+tpsps........pcp.hpPRsss.lh.ss.spsssSsohS+LKASLoKNFSILPSQDKslhQ+sssps....csc...p.spAEtL.ss...hsssEh......pcsstspchsscuC.ss.RsSVKKLIETFSP..sEplth.tso+s.GsssClR+hGhslhPPRhPhYRGLAPLYPK.pIoPusutp..phs.uW+PhAPhFPPl.tuttscpp-..h..pt.Eh-t.s.EpLPPPPLElLMDpSFsSLEsPEospsstsSscts.t.Pu.spssss..++ThsSsKL+AShsPhDLLPSKssssss.t.pus.usGss+stspsRc.sL-lpp...sPssstssEhps...tt....sps-cAsuL.+pspKslshppsu..s..SGps.ps.Esuh...uRs...............+pupE+SPshsRKsSPoRsp.Wssps-+R..S.PusaR.........uQPS.sslpp..P....SPPh.........SP+s............hSPP.st+c.sSPPhp.KhPoPP....s............pp.sSPPsp+.EsusPsshso..PSPPhSPSps.Kpsp....co.--spss.uKsuuNspSIFCPAoSSLFEA+...ss.s.sp..ss....PEsGs..ttss.shRsS.tsh.hu-pQRphslsAhNP.PFlRRohSD+p.....t.t.t......t.....t....p.t.spssu..t.EEus.p-sts.hssspss-lpt.us+.su.P-hhVlGpGLQ.................................................................................................................................	0	1	6	14
+15305	PF15450	DUF4631		Domain of unknown function (DUF4631)	Eberhardt RY	re3	Jackhmmer:A6NI56	Family	This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 394 and 668 amino acids in length.	28.00	28.00	29.70	28.60	27.90	27.60	hmmbuild  -o /dev/null HMM SEED	532	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.91	0.70	-12.85	0.70	-6.22	8	50	2012-09-21 08:26:51	2012-09-21 09:26:51	1	3	32	0	23	51	0	415.00	42	75.89	NEW	LsSosssPEQDTsKRWcQLEQWVA-LQAEVssLRGHKpRCE+AoLSLLRELLQVRA+lQlQsSELcpLppEl+.psAhsPEKEA.EhSGsQ..sQNQMQALDKRLVEVREALTQIRR+QALQDoERKGuEQEAsLRLs+LoshL+QEEQuREsACSuLQKsQE-uSQKVDcEVARMQAQlTKLGEEMSLRFLKREAKLCGFLQKSFLALEKRMKASEooRL+sEsuLREELEuRWppLQELsEERLRuLpGQpEVususp.QpEEu+LLEQCRGLDpAVVQLTKFVcQNQsSLNRVLhAEQKAR-AKspLEESpApELAuYlQENLEAsQLA......u-LApQETpssLELLQ.EKSQsLEsSVApLspQLKDLsDHhLALSWRLDLQEQTLuLRLoEs+s.EWEGsER+SLEcLAphpcEspAHL+EVpEKVD.uLPQQIEuVSDKClLHKSDSDlKIsAEG+AREaEVcslRQELAsLLSSVQLL+E-NPGRKIAEIQGKLA..TsQIhKLENSIQsNKTIQNLKFNTETKLRoEEhAoLRESh	.......................ppt...pQDs.pph.Q.pp.hspLps-lsplRtpppp..s-pthhtL.p-lhpl+sphphQso-Lhplpp-h...hs.s......-..st.....psthphLDpRLhEl+EtLsplp+p.s.pps-RctsppphshRLs+Lssh...LpQE-psREsACusLpKsQE-sup+ls.E...sA+hp.AplscLuEEhSL+FL+REAKLCuaLQKsFh.ALEpthKspEssR..hEtsLttELEs+WptlpthhE-+ltuLpuQp-..........tEcu+LlEQCpuLDtAVstLT+FVppNQsSLs+lLhAEtKAh-u+splEcopst-LsshlppslEAhphu......uc.ApQEhpspLplLp.EKspsLEsSl.spLsppl.+-Lss...+h.ALS.+...............lDLQEQhLsh+Ls-s............ps.Eapusc+csLcclsphpcEspscLctlpEKV-....ulPppIcslSsKCllhKsDsDh+IssEu+sRch-ltslRQELAslLpulQLL+EcsPu.....RK........IAEhQGcLs..ppQIhKLEsslQssKTlQNL+FNsEs+hRhp-hAsL+Eph...........	0	6	7	11
+15306	PF15451	DUF4632		Domain of unknown function (DUF4632)	Eberhardt RY	re3	Jackhmmer:A6NIN4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 59 and 190 amino acids in length.	27.00	27.00	126.50	126.40	24.00	18.50	hmmbuild  -o /dev/null HMM SEED	71	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.77	0.72	-9.45	0.72	-4.05	5	14	2012-09-21 10:53:32	2012-09-21 11:53:32	1	2	12	0	8	17	0	69.60	77	70.53	NEW	AGuPAKESGDsDGEAD.EEGESEKGAGPRSAGWRALRRLWDRVLuPARRWRRPLPSNVLYCPEIKDIAHMTR	hGsPAKESG-.DGEsD.-EtESEKGAGPRSAGWRALRRLWDRVLAPARRWRRPLPSNVLYCPEIKDIAHMTR	0	1	1	1
+15307	PF15452	NYAP_C		Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter	Coggill P	pcc	Jackhmmer:Q6ZVC0	Family	NYAP_C is a C-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8 [1]. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice [2].	25.00	25.00	33.40	33.20	23.70	18.80	hmmbuild  -o /dev/null HMM SEED	308	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.27	0.70	-12.17	0.70	-5.42	3	80	2012-09-21 12:13:01	2012-09-21 13:13:01	1	6	35	0	40	66	0	245.10	47	38.50	NEW	LASPHSLPDPTusPL.sPLWTYPoT.AGLKRPPAYESLKAGGlLsKGCGVGAPuPMVKIQLQDQGTsGGAFASISCAHVIAS..SGTPEEE...EEEVGsuTFGAGWALQRKVLY.GRKsKDp.-TEssEGuRAWNGSuEGPSKsEREEK...GsLoSGIPVRSQGAEGLLARhHHuu+....GGSRTGLPlPCQTFPACHRNG.DFTGGYRLGRSASTSGVR..psslHTPRPCSQPR-ALSQsHPAL..sLPLPPQPu+ERDGKLLEVIERKRCVCKEIKARHRPDRGLCKQESMPILPSWRRGPEPRKSGTPPCRRQQTVLWDTAI	...............................tSPHuhP..cspuus..oPl.h.h.u.s.shuLKRPPsY-Sl+uGul.ppu...usPpshs+.plQ-tu.p...suAh.so.h..usupshup...utTPpp.....EE.hsuhFsuGhuL.RKs....GtRptc...h.-..cspDth+shstSs.Es.sKlEpc-R....Gs..su....St.P....V+....uQth-Gh.....tss............suSRhuhs.ss.Th.Asp+su.-.psuh.RLGRSASTSGV....su.l.p.s.R.sSps.p.s................................................................................................................................................	0	1	3	13
+15308	PF15453	Pilt		Protein incorporated later into Tight Junctions	Coggill P	pcc	Jackhmmer:Q5JTD0	Family	Pilt is a family of eukaryotic tight junction-proteins that binds to guanylate-kinase. Pilt is a component of TJs (Tight junctions) rather than AJs (Adhesin junctions). The protein is incorporated into TJs after TJ strands are formed, thereby suggesting the name Pilt for 'protein incorporated later into TJs'. Pilt binds to the guanylate-kinase region of hDlg otherwise known as Disk large homologue [1].	27.00	27.00	27.00	27.00	24.10	24.10	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.36	0.70	-4.74	15	99	2012-09-21 13:25:27	2012-09-21 14:25:27	1	3	38	0	48	81	0	224.40	47	54.09	NEW	Moss..ss..........sus..tstpsspQ.pNGpCpSpuoh-uss..E-.hslPuFEKLNPYPTPsPPHPLYPGRKVIEFS.-DKV+IPKNSPLPNCTYATRQAISLSLVQs--..c+.s.........+s.ussPs.......o..P..uSs......s..........uSsQssP.S...............................s.PQ.sPSshASSuSSEEDL.LAsWQRMFVEKssPou-tull.pRTuFS+-TAtELQ++h.sh...us..ushspsssAa...........................................................us..u.-Eus.pll.........sttssstps+-c...p-lslPsSspEE..+..p.LLptpcttppsss.stp..scs....................stssSuRPQRSPKRMGVHHLHRKDSLTpAQEQGsLL	......................................................................................................................................st...........us..hstpst.Q..NGpCps.uostuss..E-..shPuF..EKLsPYPTPsPPHPLYPGR+VIEFS.-DKV+IP+NSPLPNCTYATRQAISLSLVppss..cp.t.........p..sssss.............s..s..tus..................tuspppP.s......................................s.s..h.Ss.ASS.uSSEEDL.LusWQRhFV-+hsPsu....s..h..spRTuFuccshs-L..Q++h...sh....us....sshst.h.s........................................................................h..............s......ptt.............th.ls.Sst-p..pp.l...t...t.h...t.....t..............shss.pRPp+SPKRMGVHHLHRKDSLTpAQ..GsLL.................................	0	1	7	18
+15309	PF15454	LAMTOR		Late endosomal/lysosomal adaptor and MAPK and MTOR activator	Coggill P	pcc	Jackhmmer:Q02205	Family	LAMTOR is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes. It is found to be one of three small proteins constituting the Rag complex or Ragulator that interact with each other, localise to endosomes and lysosomes, and play positive roles in the MAPK pathway. The complex does this by interacting with the Rag GTPases, recruiting them to lysosomes, and bringing about mTORC1 activation.	25.00	25.00	25.20	25.50	24.20	24.60	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.07	0.72	-9.53	0.72	-3.69	45	181	2012-09-21 14:43:52	2012-09-21 15:43:52	1	2	170	0	125	166	0	75.80	28	44.32	NEW	psEpo+LLscs...ps...shstht....st.s........pssspphp.Rc.pAL.ssIlpcTu-slIDlsuhpsps...ht..ppp.hs.s.phhst	...............sEpp+LLt-s.....ps..s.stht..pssp.s...........pppspphp..cE.pAL.psIltcTusslIDlsuhsspsh...tpp.h...p....s...........	1	25	52	91
+15310	PF15455	Pro-rich_19		Proline-rich 19	Eberhardt RY	re3	Jackhmmer:A6NJB7	Family	This family includes proline-rich protein 19.	27.00	27.00	40.10	40.10	21.20	21.20	hmmbuild  -o /dev/null HMM SEED	357	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.51	0.70	-12.14	0.70	-5.42	8	30	2012-09-21 15:10:35	2012-09-21 16:10:35	1	2	24	\N	15	29	0	307.60	61	73.26	NEW	MDPRGPAPQPFQQPEKPGRVRRRKTRRERNcALV.......GSRRPLA+Q-PPVASRDP......P......VuPsAPKLVVITQGRLSREHRGLFNHEVKSLDVARLLSSGoLEPsTPsLsTKPSPSPGRuQEPu...QSRGKENQVPGGSGPGPPSsPELPGlGQLLpELQCQLlLPQAFPRRNLVQEARDAIVGTLQACHGCVPDLuLVLRGCQPPLP..GsKPpssERpRMTPSWINSPEQ..APtEGRQRRp..QGTKElTFsMPHT.SSTPTsHRsSLsPP+GPW.....PPsLPSLsSPSGsAWGPPTAFDLLKSIWLVATPP...PP+PWGVGPPQPLPQPPSPLLPRTSALDWSPSPPAPLPSLSWVVAQSSPEAWSFPPMRLY	.........MDspGPssQPFQpPEKPGRVRRRKTRRERNcALs.................GSRRPLs+pDPslupRDP.............P......VsP..sAsKLVVITQGRLSREHRGLFNHEVKSLDVARLLSutsLpPsoPsLPsKPSPS.......PuRuQEPu...QSRuKE....NQVPGGSGPGPPSs..P-LPulGQLLtELQCQL.LPQAFPRRNLVQEARDAIVtTLQACHGCVPDLuLVLRGCQPPLP..GsKPtssER.+MTP.WINsP-Q..sPtptRQR+p..pGTKEhsFshPaT.SShPssHRsSlsPP+uPW.....PP.hs.hsSPSGsAWGPPTAFDLLKSIWLVATPP...PPpPWslG.sQPLPpPsSPLLPRTSsLDWSPsPPAPLPSLSWVVAQSSPEAWSFPPMRLY..................	0	1	2	2
+15311	PF15456	Uds1		Up-regulated During Septation	Coggill P	pcc	Jackhmmer:Q9P6S3	Family	Uds1 is a domain family is found mostly in fungi, and is typically between 120 and 138 amino acids in length. The GO annotation for the S.pombe protein describes the protein as barrier septum assembly involved in cell cycle cytokinesis, GO:0071937. Many of the uncharacterised members are listed as being involucrin repeat proteins, but this can not be substantiated.	27.00	27.00	27.00	33.30	26.90	24.90	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.42	0.71	-4.13	55	148	2012-09-21 15:33:05	2012-09-21 16:33:05	1	4	90	0	122	149	0	126.70	34	15.67	NEW	tlcLLscsAlsDSppaElLohEEV-sLKKEhphLspRlcss+cpLs.lcsKhR-.AAtS..ls+Lhsstptt.......................t.sppshpcs-cpLstss++s-Ehsp-LhplEpRhtclcp+LLEHsAulLphop+	............hcLLpcpAhs-upcaElLshEEV-sL+......+.....Ehph..............LspRl-hh+cphs.lctchRc.usts.lsphhpssptt.............................................sphspcshhcpEEtLup.-pph-EhspcL.phEpRttcl+p+LLEHsAulLphs........	0	32	66	100
+15312	PF15457	HopW1-1		Type III T3SS secreted effector HopW1-1/HopPmaA	Coggill P	pcc	Jackhmmer:Q8RP17	Family	HopW1-1 is a family of bacterial modular P. syringae Avr effectors that induce accumulation of the signal molecule salicylic acid (SA) and the transcripts of HWI1 (HOPW1-1-INDUCED GENE1) in Arabidopsis. Thus HopW1-1 elicits a resistance response in Arabidopsis [1].	27.00	27.00	64.80	64.70	22.20	21.30	hmmbuild  -o /dev/null HMM SEED	321	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.91	0.70	-12.11	0.70	-5.39	5	28	2012-09-21 15:54:11	2012-09-21 16:54:11	1	1	20	0	1	31	0	288.10	65	38.93	NEW	MMPSQITRSSHSSLP-sSPASuDAsSSpEQSPQQsRT+AFVASGELusAFGRTSTAPAQDsVRLLusLQREL-KcsPSaP-VApLuppLAEAAMTEQGhHhLAoEE.Q.psLKslLDRCT+QLADTPAScASHDuLSQACEGLKTARLHQSlApLTGcoHApsRGVPDLLALsHLDP-VLA-KPsuhsSYspFGSFIpTAKsRTA-Ls-SLpcsuuEVsuLLRuHADTLpuLE+LPuALAALTENCPDsPTpcDLRuLAEsAGELLQQLRssDLLPRSEEISSEsGEosV+u+EsVE...P+LTpuQALLhAGGNLVRKFDAYGAl	.MMPuQITRSSHSSlP-susASuDAsuspEQoPQQsRThAFhASGELusAFGRTSsAPtQDsV+LLusLQREL-KppPSa.sVApLsppLAEsupTEQGhH.LAoE-.Q....sL+-lLDRCpppLADhPAucASHDsLSQACEGL+TARLHQSlApLTucspuhsRulsDLLsLsHLDP-sLutcPsshoSYshFupFlpTAKpRTA-Ls-sLpcpPstVsuLLRuHADTLp-LEhLPuALtALTENC.DsPsps-LRpLAEsAGuLLQhLREpDLLPR.EEIS.EsGEuPs.u+EssE...P+LTppQALLKsGGNLVRKFDAYGAl......	0	0	0	0
+15313	PF15458	NTR2		Nineteen complex-related protein 2	Coggill P	pcc	Jackhmmer:P36118	Family	NTR2 or Nineteen complex-related protein 2 is a family of largely fungal and plant proteins that form a complex with the DExD/H-box RNA helicase Prp43. Along with NTR1 it is an accessory factor of Prp43 in catalysing spliceosome disassembly.  Disassembly of the spliceosome after completion of the splicing reaction is necessary for recycling of splicing factors to promote efficient splicing [1]. NTR2 and NTR1 associate with a post-splicing complex containing the excised intron and the spliceosomal U2, U5, and U6 snRNAs, that supports a link with a late stage in the pre-mRNA splicing process [2].	27.00	27.00	27.80	28.00	26.30	26.10	hmmbuild  -o /dev/null HMM SEED	254	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.71	0.70	-5.14	41	137	2012-09-24 10:30:19	2012-09-24 11:30:19	1	6	131	0	107	140	0	244.70	26	44.95	NEW	spYsp-YlsELpsuTsss.P..............tp-tp...........hsl-shph.st.h.................spsstIPocuEIcEtKpRRsRL...spcp...............pc.alSLpD....p-ctth..............cpppt-oRLsc-D--h..sEGh--asp....Ds+luL.G++sc+pppp++RcphpEhIps...........p-s-sEcpts..aEssQh+tGhsshp.................th.p.s..................PphssLP...pLsssl........p+Lppsl...sshptpppphppplppLpcE+tcIspRcp-lpphlpc	...................................................YspcYlpELpsso.ss..Ppt......................ts.p......................hpl-..t....th.sthh..................spsssIPocucIcctKpRRs+h.........tpcp..................tc.aIuLp-......tsp.pph............t.cppptcoRLlp-D--h..sEG.h--asp....DspluL.Gc+sc+cpcc+...+Rppht-hIsc..................ttts-s-sEcptt....aEssQhRtGhsshp.................................t...t..p.s...................................sphssLP...pLsssl.............t+Lpptl...sthctppsphttplpp.LccE+t-lttcct-lpthlp..........................................................................................................................	0	34	59	89
+15314	PF15459	RRP14		60S ribosome biogenesis protein Rrp14	Wood V, Coggill P	pcc	Pfam-B_10508 (release 26.0)	Family	RRP14 is a family of nucleolar 60S ribosomal biogenesis proteins from eukaryotes. RRP14 functions in ribosome synthesis as it is required for the maturation of both small and large subunit rRNAs and it helps to prevent premature cleavage of the pre-rRNA at site C2 [1]. It also plays a role in cell polarity and/or spindle positioning 2],	22.40	22.40	23.20	23.20	21.60	21.60	hmmbuild  -o /dev/null HMM SEED	64	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.79	0.72	-9.32	0.72	-3.90	54	167	2012-09-24 12:25:37	2012-09-24 13:25:37	1	6	153	0	128	164	0	56.80	45	11.77	NEW	c-cL+pHuptFDsLlsLIPAKaYhs.-csp.............cphKp..KKpo...KcptKpA...K+sKLDP-	...p-RL+sHupuFDuLLuLIPAKaYas.--ss................cQh+p......KKpT...K-ps+pA...KRuKLDP-....	0	43	79	112
+15315	PF15460	SAS4		Something about silencing, SAS, complex subunit 4	Coggill P	pcc	Jackhmmer:Q04003	Family	SAS4 is a family of largely fungal silencing regulators. This silencing is mediated by chromatin. SAS4 specifically silences the yeast mating-type genes HML and HMR [1]. SAS4 is found to be one subunit of a complex, the SAS complex, that interacts with chromatin assembly factor Asf1p, and asf1 mutants show silencing defects similar to mutants in the SAS complex. Thus, ASF1-dependent chromatin-assembly may mediate the role of the SAS complex in silencing [2]. Co-expression of Sas2, SAS4, and Sas5 in Escherichia coli leads to formation of a stable SAS complex that acetylates histones. SAS4 is essential for the acetyltransferase activity of Sas2, and Sas5 is also important [3].	22.50	22.50	22.90	23.20	20.90	22.20	hmmbuild  -o /dev/null HMM SEED	101	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.54	0.72	-10.33	0.72	-4.14	48	116	2012-09-24 12:56:10	2012-09-24 13:56:10	1	1	114	0	88	119	0	97.90	40	18.86	NEW	DPLsDshYpshH++hcRpE+phpNt-+tRuppEt-pLpclL-tLpsh.............DWlRsh.slTs.Is-.s-cc-hEsKRphhlcplpslLcKFcpW+ccccchp.tcpc	........DPLsDshY.hhH++hERpE+plRNtE+tRupaEp-pLp+LL-pLpuh.............DWLRlh.Glou..ls-..s-++phEsKRphh.......lctlpulLcKFctW+ccE++p+hc..c..............	0	15	43	73
+15316	PF15461	BCD		Beta-carotene 15,15'-dioxygenase	Coggill P	pcc	Jackhmmer:Q4PNI0	Family	BCD is a family of bacterial and archaeal proteins is found in bacteria and archaea that catalyse or regulate the conversion of beta-carotene to retinal [1]. Characterisation of BCD proteins shows them to cleave beta-carotene at its central double bond (15,15′) to yield two molecules of all-trans-retinal. However, the oxygen atom of retinal originated not from water but from molecular oxygen, suggesting that the enzyme was a beta-carotene 15,15′-dioxygenase, rather than a mono-oxygenase that catalyzes the same biochemical reaction [2,3].	27.70	27.70	54.90	54.90	27.60	27.60	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.98	0.70	-4.97	56	106	2012-09-24 13:25:51	2012-09-24 14:25:51	1	1	93	0	33	115	1588	261.10	23	85.69	NEW	llullhlGlPHGAhDthlsh+h.h.........phpthhtahshYlslushhlhlWhhhPshuLhlFlhlohhHFGpuDhtth...........ssh...chh..th..........ls+GGhlhhhls.hh.ph.....sc........shtlh.shl.ss......ss.tsh..............shp.......s.....lhh.hhhh....hh.luh.h...h......hh...htthp........tc.tht.h.....hsEhs...hLhhh.FhhlPPlluFulYFslhHShRHltchh................ppl....st.ts...st.t...........h.............hhp.puhsh...olsuhlh..hs...slhh..hhss...shsh......tss...h....lthhhlhlAuLTlPHhlllshhc+c	.................................lullhlGlPHGAhDhhlsh+h.h..........php.hhhahshYlslsshhlhhWhhtPshuLhlFlhlohhHFGpsDhthh...........sph..phh.h...ls+Guhhlhhss.hh.phsp........shtlh.shlss.......ss..sh..............hht..h....hhhhhhh....shlsh.h...h..hh...htt.ht........tptht.h....hs-hhlLhhhhhhlPPlluFulYFslhHSh+phhphh................ttl.....pt.tt....ht.............h...hhtpshsh...shhuhhh..hs...shhh..hhss...s.........tst...h....lthhhlhlAuLTlPHhllsshh...................	0	12	25	29
+15317	PF15462	Barttin		Bartter syndrome, infantile, with sensorineural deafness (Barttin)	Coggill P	pcc	Jackhmmer:Q8WZ55	Family	Barttin is a family of mammalian proteins that are chloride ion channel beta-subunits crucial for renal Cl-re-absorption and inner ear K+ secretion. Bartter syndrome is a term covering a heterogeneous group of autosomal recessive salt-losing nephropathies that are caused by disturbed transepithelial sodium chloride re-absorption in the distal nephron. Mutations in the BCD proteins lead to sensorial deafness.	27.00	27.00	47.90	46.70	18.70	17.30	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.69	0.70	-11.71	0.70	-4.69	11	35	2012-09-24 13:54:09	2012-09-24 14:54:09	1	1	25	0	16	28	0	204.70	63	69.83	NEW	SHDRPQVYGTFYAMGuVMVIGGVIWSMCQCYPKITFVPADSDFQGlLSP..KALGLLENGLusEhK...u..PQPPYVRLWEEAAYDQSLPDFSHIQMKVhGYSEDPRPLLAPc.up...p.tuuDGGcG.uPp-uQAWlEAAVVV......HRGSDEcEGcRss.oQSpsuPPssPQGP...APLASFQDDLDhGSSEGSSPsPSPPstEEPpsPs.tEP..hAsRs.LDRFcDFALID.uP.TsED	...SHDRPQVYGTFYAMGulMVIGGlIWSMCQCYPKITFVPADSDFQGILSP..KAhGLLENGLusEhK..S..uPQPPYVRLWEEAAYDQSLPDFSHIQMKVMuYSEDPRsLLAP-huQ...chGsSDGGEG.GPtDsQAWhEAAVVl......HRGSDEsEGERph.oQShPuP.u..CPQGP...APLASFQDDLDhuSSEGSSPssSP.-tEEspsPp.pEP...uCRs.LDRFpDFALID.APThED...................................	0	1	2	4
+15318	PF15463	ECM11		Extracellular mutant protein 11	Coggill P	pcc	Jackhmmer:Q04110	Family	ECM11 is a family of largely fungal proteins. ECM11 interacts with Cdc6, an essential protein involved in the initiation of DNA replication, and is a nuclear protein involved in maintaining chromatin structure [1]. It was previously identified as a protein involved in yeast cell wall biogenesis and organisation, but is also found to be required in meiosis where its function is related to DNA replication and crossing-over [2].	25.00	25.00	26.20	25.50	22.80	22.00	hmmbuild  -o /dev/null HMM SEED	139	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.97	0.71	-10.47	0.71	-3.89	53	98	2012-09-24 14:36:33	2012-09-24 15:36:33	1	3	98	0	76	99	0	135.80	26	27.89	NEW	DYssptLpphsas-LpspsFD..hsPssht...............................ttsssss...shpp.+....lpphhpt..sppp...pc....phFushohc-W--sGDhhl-pFspllp+lpcsRpp+RchhphFEsEIscRpcsVptcsptlscKLpch+ptGpcll	......................................................................................................DYssthL.phsas-LpspsFD..hsPssst..........................t..ss......slp-.+....lpphhsh....scpp...pc..........paFusholsEW--sGDhhl-pFsplhp+h+csRpp+RphsthFEsEIpcRt-sVctcspt...lsc+Lcch+ptGtcll...	0	12	36	63
+15319	PF15464	DUF4633		Domain of unknown function (DUF4633)	Eberhardt RY	re3	Jackhmmer:A6NJI1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 123 amino acids in length.	27.00	27.00	69.70	69.50	22.20	21.60	hmmbuild  -o /dev/null HMM SEED	115	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.78	0.71	-10.52	0.71	-4.24	6	20	2012-09-24 14:54:23	2012-09-24 15:54:23	1	1	18	0	12	20	0	109.70	68	95.26	NEW	MGTuLRSQSLRGPpPSYGKLQEPWGRPh.....EGRLRRALSLRpGREKSRSp..-.tGPEtLDssGQEhLPGoLGDTEQLIQuQp.usSRRWLRQYQQpVRRRWcS.FVuSFPsVTLSpPAS	MGTGLRSQSLRGPRPSYGKLQEPWGRP......EGpLRRALSLRQGREKSRSQsL-...tGsEGLDssuQEtLPGoLGDTEQLIQAQR.uGSRRWLRQYQQpVRRRWcS.FVu.FPSVTLSQsAS	0	1	1	2
+15320	PF15465	DUF4634		Domain of unknown function (DUF4634)	Coggill P	pcc	Jackhmmer:Q8WWF1	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 98 and 133 amino acids in length.	27.00	27.00	33.40	48.00	18.80	17.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.76	0.71	-3.94	9	32	2012-09-24 15:04:50	2012-09-24 16:04:50	1	2	22	0	14	26	0	117.90	64	98.13	NEW	MDVLFlAILAVPLILGQEYEDEEtLEED-YYQVsY.YYTVTPoYDD..FusNFTlDYShFESEDRL.N+.LDK-V..TEAVETTI...SLpTcttD+p+PVTlKPVThE.P...........SPDLNDA.VSoLpSPlPLLLShsLVQuGMY	.MDVLFVAILAVPLILGQEYEDEEtLtE.D-YYQVlY.YYTVTPsY.DD..FuusFTlDYShFESEDRL.N+.LDK-l..TEAsETTI...SLcTttsD+.KPVTlKPsThE.P.............SPDhNcA.VSuLpSPlsLLL.hshlQsGha.................................................................	0	1	1	1
+15322	PF15466	DUF4635		Domain of unknown function (DUF4635)	Eberhardt RY	re3	Jackhmmer:A6NLE4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 120 and 154 amino acids in length. There are two conserved sequence motifs: LEQ and DLE.	27.00	27.00	110.20	110.00	22.10	21.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.78	0.71	-4.88	6	26	2012-09-24 15:10:22	2012-09-24 16:10:22	1	1	19	0	12	15	0	130.80	70	94.84	NEW	MslQ......cVGsRtRsuA..........E.....lhERRccS.+C-.....DKKQoLLuLLILVLYLGTGI..SG+SWEVSERIRECNYaQNsVsSQGhEYQTsEPuEEPlKslRpWLKENLHVFLEKLEcEVRELEQLV+DLE.WLDALLGDsahEEPCS	.........MshQQVuuRtpVAA...............E.....LlEpRRsS.HC-.....D+KQTLLALLILVLYLuTGI..SGSSWEVSERIRECNYaQN.VsSQGhEYQTsEPSEEPIKslRsWLKENLHVFLEKLEcEVpELEQLVpDLEhWLDALLGE..s+.EE.Cu..	0	1	1	1
+15323	PF15467	SGIII		Secretogranin-3	Coggill P	pcc	Jackhmmer:Q8WXD2	Family	Secretogranin_3 is a family of vertebrate proteins that is one of the granin family. Granins are rich in acidic amino acids, exhibit aggregation at low pH, and possess a high capacity for calcium binding. Because granins are restricted in their localisation to secretory granules of neuroendocrine cells, two interesting characteristics of their sorting mechanisms have been observed.  These are, first, that they aggregate on low pH/high calcium concentrations and second that two of them carry an N-terminal disulfide loop, mutations in which lead to mis-sorting. Thus, granins are thought to be essential for the sorting of secretory proteins at the trans-Golgi network. Chromogranin A (CgA) binds to SGIII in secretory granules of endocrine cells [1]. SGIII directly binds to cholesterol components of the secretory granule membrane and targets CgA to secretory granules in pituitary and pancreatic endocrine cells [2]. Mutations in the SGIII gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion [3].	27.00	27.00	60.80	60.70	21.40	21.40	hmmbuild  -o /dev/null HMM SEED	453	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.76	0.70	-12.79	0.70	-5.40	8	53	2012-09-24 15:34:09	2012-09-24 16:34:09	1	2	36	0	27	59	0	404.80	72	96.68	NEW	plpAFPsPsuu.cDKulYNRELoEERPLpEQIAEADolKt....ucopsttspp-pcN.pDsDDLslLKSLAEppK.sKcsuslpsoh.-cphssDDoDSTKsRRLsDDYDSTKsGhDY.KYQDDP-uhRQLDGTPLTAEDIVQKIAs+IYEEsDRGVFD+IVSKLLpLGLITESQAcTLE.EVAEALQcLITKpAKNNEh-stshsttss+u-p......................ssscpscp+h..........h..ts.p........--o......susoWs..pshEcRNElsPEDshpDLQYFPNFY+LLKSLsS.EpDscE+ETLITIMKTLIDFVKMMVKYGTITPEEGVSYLENLDAMIAlQTKNKLGKuLu...ssshssPs-..Ksh-EsDsTKsEAAKMpKEYEsLKDSTK-E.Qsso-.s-cP.GKSEoYLEAIRKNIEWLKKHNK-GNKE..DYDLSKL+DFhDQQsDuYl-KGIL-KEEuDsIKRIYSSL	..........lpAFPpPsuu.pDKslHNRELSsERPLpEQIAEAEuDKh....+cshssENKsuppNYSFlDsLNLLKAlsEKEK.EKE+pSlRSSsh-s+Lsl-DsDSTKNR+LlDDYDSTKSGLDa.KaQDDPDGLHQLDGTPLTAEDIVpKIAsRIYEENDRGVFDKIVSKLLNLGLITESQAaTLEDEVAEsLQcLIoKEApNhEc-....scPsS+oEs........................psschsEc.h.....TshAuhQ.DuhspsEND-T..lSNThTLoNsLERRscsasEDsFE-LQYFPNFYALLKSIDS.EKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENLD-MIALQTKNKLEKNsTp..hS+LFsuPoE..KSpEEoDSTKEEAAKMEKEYsoLKDSTK--psssus.T-EPKGKTEAYLEAIRKNIEWLKKHsKKGNKE..DYDLSKMRDFINQQADAYVEKGILDKEEA-sIKRIYSSL......	0	1	3	11
+15324	PF15468	DUF4636		Domain of unknown function (DUF4636)	Coggill P	pcc	Jackhmmer:Q8WWF3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 196 and 244 amino acids in length.	27.00	27.00	59.00	58.60	21.50	21.00	hmmbuild  -o /dev/null HMM SEED	243	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.33	0.70	-11.47	0.70	-4.91	8	36	2012-09-24 15:38:09	2012-09-24 16:38:09	1	1	27	0	19	25	0	224.10	63	98.88	NEW	MG-LhSLFWEVDPPPlPLoaoIPsQDaECpKDDSCGAIGSFLLWYFlIILVLMFhSRASVWMS.EpKcDEDSGTSASVSKASKDsSYKRQsK-GsWDSsQhM..KKPKQsQLoPVTDSEVALVNAYLEQRRAp+HSQhsQVNQlppDSDTTEsDSEESNSGASSWKESESEHHPSPAuI+RRKlAQRQ+slGSYQIRERPCLHCKAMRTNEWLTRHFLQssSsssPhKuDhQEENSlPEINTKFSK	....................MGcLaSLFWEhDPPshPLshsIPsQ-aECt..KDD..SCGslGsFLLWYFlIlhV...LMahsRASlWMS.EsK+...DEc..SGT.SsSluKASK-sShKcQSK-u.sWDs.QhM...K.KPKQsQLoPV..TDSEVALVNAYLEQRRAR+pSQFspVNQsQ+DSDTTECDSEESNStASSWKESESEHHPSPsSIKRRKhAQRQRNl.GSYQlRERPCLHCKAMRTNEWLsRHFhQpsSlssPMKG.D.QEEsShs-.INTKFSK.....	0	1	1	4
+15325	PF15469	Sec5		Exocyst complex component Sec5	Wood V, Coggill P	pcc	Pfam-B_353125 (release 26.0)	Family	This Sec5 family of eukaryotic proteins conserved is not representing the Sec5-Ral binding site.	30.00	30.00	30.60	30.70	29.40	29.80	hmmbuild  -o /dev/null HMM SEED	182	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.89	0.71	-4.55	80	361	2012-10-03 17:31:52	2012-09-24 17:03:10	1	14	260	0	261	467	2	197.60	24	22.04	NEW	scplcpLlcsNFspalpsKsslDslapph..............pp...pptp.ttpt..........................................shppLpppl.pp...stppusphhpslLcppp+scphRsslshlp+h+hlFsLP...pplccs..lpc.s-Ycthlp-Y.......p+u+slhppp.................................psplhc+.....las-VEphh..pph+pplhppLhsss....................pshcp............hpphI.chLlcL........ps..........pt............cPhhhhlssp	...................................p.tthphlVcsNaspFlpspsolcslhpch............................................ct......ptpp....tt........................................................................hsppLpsslpp...ssspupplapslLsp+p+t-pl+sslshlp+h+hl...FsLP...sslpcs..Ipp.t-Y-tslp-Y...............p+A+slhtps..................................pl.lhp+..............................hhp-VEphl.....pph+c..pLhc+Lhpss.................................pshcp......................ttchl..phLhcL....................ps......ps................sPhW.hl..................................................................................	0	99	153	221
+15326	PF15470	DUF4637		Domain of unknown function (DUF4637)	Coggill P	pcc	Jackhmmer:Q8WW18	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 142 and 178 amino acids in length.	27.00	27.00	43.00	42.30	21.70	21.70	hmmbuild  -o /dev/null HMM SEED	173	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.83	0.71	-11.32	0.71	-4.64	5	25	2012-09-24 16:10:32	2012-09-24 17:10:32	1	1	22	0	13	24	0	151.70	67	90.85	NEW	MDKHGVKTPLWKKElEEPRAcEsEtEEAcEGSE-EDEsppRPPEESAAEGEt-uR.AEtsEGRERRSVSYSPLRQESSTQQVALLRRADSGFWGWLSPFALLGGLAAPADRKRSLPEEPCVLETRRRPPRRGGCARCEILFCKKC+oLHSHPAYVAHCILEHPDLGKAsAuGu	................MDK+..GVKTPLWKKEsEEscAcEsEtE..c..tcEGS....E.-c-p..pRsstESAsEGE..E.s.R.A-EsEGRERtSVSYsPLRQESSTQQVALLRRADSGFWGWLuPhALLGGLsAPsDRKRShPEEPCVLEhRRcPPRcGGCA+CEILFCKKCRoLHSHPAYVAHClL-HPDLG+AtAuGu.....	0	1	1	2
+15327	PF15471	TMEM171		Transmembrane protein family 171	Coggill P	pcc	Jackhmmer:Q8WVE6	Family	This family of proteins is found in eukaryotes. TMEM171 is also known as parturition-related protein 2. Proteins in this family are typically between 242 and 326 amino acids in length.	25.00	25.00	25.20	172.40	24.50	24.40	hmmbuild  -o /dev/null HMM SEED	319	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.44	0.70	-12.04	0.70	-5.64	10	40	2012-09-24 16:12:44	2012-09-24 17:12:44	1	1	32	0	22	37	0	297.50	63	97.65	NEW	SPsAAAEPDG-ppDRpVSKLIFFLFVFGAVLLCVGVLLSIFGFQACQYEsLsDCShVLKlAGPuCAVlGLGsVILARSRARLQl+ptphQGpQsDPDpAFlCGESRQFAQhLIFGFLFLTSGMLISILGIWVPGCuSsWsQEPLN-TDouDuEPQICGFLSLQIMGPLIVLVGLCFFVVAHVKKRNNLNsuQDASEsEEtpoQSsEPVQVTVGDAVIIFPPPPPPYFsEoSASAso.pSPGANuLLPsENPPSYYSIFsaG.RT..P-..sQGssSERDpESIYTISGTssSSEISHsPHLsSE.PPRYEEKETssuTsLSsSS	..........SssusAEPDG-ppDR+lSKLIFFLFVFGAlLLCVGlLLSIFGaQACQYcslscCuhVLKlAGPuCAVlGLGAVILARSRA+LQLRptphp.GpQhDsDpuFlCGESRQFAQCLIFGFLFLTSGMLISlLGIWVPGCuSsWs.Q-sLNETDou-uEPphCGFLSLQIMGPLIVLlGLCFFVVAHVKKRsNLNsuQDu.SEpEEtpsQosEPVQVTVGDuVIIFPPPPPPYFsESSuSA.ls.pSPGuNuLhPsENPPSYaSIFNaGpT.hP-sQGsAoERDpEoIYTISGssSSSEhStss+LsSELPPRYEEKEsssss.Ls.SS.....	0	1	2	7
+15328	PF15472	DUF4638		Domain of unknown function (DUF4638)	Coggill P	pcc	Jackhmmer:Q8WTQ4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 240 and 272 amino acids in length.	27.00	27.00	41.20	41.20	22.40	21.80	hmmbuild  -o /dev/null HMM SEED	268	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.94	0.70	-12.02	0.70	-4.80	7	31	2012-09-25 09:50:52	2012-09-25 10:50:52	1	1	25	0	16	34	0	224.40	51	86.44	NEW	MoEps.DhcsLMPTERKShWRTAEERRMSDLTRVLEWLERRQGKK+Qs.p+pKpcsps...ss.tKtpKKspGhpc.tpttsp+ss.hspphlp.ht...+cs..ssth++h.ts-.KG+RLShlsusYs+Dus+K....S............DlDIKDsIALES.sQRsssaRRQSo.lDPhlQEs.hFGsRRuolLR-W.osKsPDssYERKLKSLMEKGhEPKhEhsKMLKPEEVLSCRYLRLSKNNIRTLLKLCKDAGMsVDIHPHMVEuEIDAKKVFupp.SVA	..............................MoEps.sh+slMPTcRK.hW+TsE-RRMSDLTRVLEWLERRQGKKKQs.pK.pKscshs......ctp.tKctKKspGhhptp......ttsp+.........ts.hs...p....psht.......++s...ssta++h.sl-.KG+RL..Shl.s.usY.h+Dus+K....S............-hDIKDsls.ES.TQRsssaRRQSh.lDPhLQ-...s.hFuuRRsohhRDW.ssKhPD.sYERKLKSLMEKusEPKhEsh+MLKPEEVLSCRYLRLSKpNI+TLlKLC+DAGhsVDIHPHM.lEt-IDs+KlFst..shA........................	0	3	3	4
+15329	PF15473	PCNP		PEST, proteolytic signal-containing nuclear protein family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:Q8WW12	Family	PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation [1].	27.00	27.00	28.30	31.90	26.70	26.20	hmmbuild  -o /dev/null HMM SEED	150	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-10.99	0.71	-3.90	11	113	2012-09-25 12:41:17	2012-09-25 13:41:17	1	5	66	0	63	106	0	125.80	61	77.26	NEW	GPEEcuEcsh+p+slSS.........osGGcuSS..RSuE+tust..............-tspsssssPsPsKlSKhGFuh..............sothh+Ks..ssISIKLGAo.....KEss..lss.p.slAuVFNtD.DDSEPEEMPPEAKMRMKNIGR-TPTSAGPNSFsKsKaGFsDspKlaERclK	.....................................................................pEtttp.hppphssS............ssuGEuoS..+SuE+pusp...........--stshssc..PsKhSKhGFu...l................uoQ...ssKKu....suISIKLGus...KPKEss......PolsPK...phoVAusF..NED...-DSEPEEMPPEAKMRMKNIG....R...DTPTSAGPNSFNKGK+GFSDsQKLWERslK..............	0	16	20	37
+15330	PF15474	MU117		Meiotically up-regulated gene family	Coggill P	pcc	Jackhmmer:Q9Y7V0	Family	This protein was identified as being up-regulated during meiosis in S.pombe.  This family of proteins is found in largely in plants and fungi. Proteins in this family are typically between 128 and 920 amino acids in length.	27.00	27.00	32.10	31.30	25.00	24.50	hmmbuild  -o /dev/null HMM SEED	97	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.18	0.72	-10.87	0.72	-3.50	16	50	2012-09-25 12:57:57	2012-09-25 13:57:57	1	5	20	0	46	50	0	101.90	29	25.76	NEW	shsCKGSulCus........ts......ssuCssAlspa..psssl............Y..............pshsu.............hspus.....ChA............hapCss..s.ss........uho......Gpplhsthpsl...csssCptCGohtass.....pCplslsYCo.sC	....s.hsCcGSuhCus.........st.....tssCcpAlsp.h...ssssh............Y.......sshou...........................hssGp.....Chs............hapssG..s.ss........slo........Gsplhssappl...cspsC.p.hCGstta..ss.....uCphslsYss.sC..............	0	11	31	44
+15331	PF15475	UPF0444		Transmembrane protein C12orf23, UPF0444	Coggill P	pcc	Jackhmmer:Q8WUH6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 94 and 119 amino acids in length.	27.60	27.60	27.70	71.40	25.50	27.50	hmmbuild  -o /dev/null HMM SEED	92	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.19	0.72	-3.93	8	68	2012-09-25 12:37:30	2012-09-25 14:34:08	1	1	40	0	44	43	0	91.50	75	79.89	NEW	sKDHPpsps....GMlWRVTGGLFuVTKGAVGATVG....GVsWlGGKSLElT.KTAVTo...VPuMGVGLVKGGVSAVAGGVouVGSuVAuK.VPhT.uKKKDKo	............KDHPQQ.QP....GMLSRVTGGlFSVTKGAVGATlG....GVAWIGGKSLElT.KTAVTo...VPSMGlGLVKGGVSAVAGGVoAVGSAVssK.VPhT.GKKKDKS....	0	2	8	23
+15332	PF15476	SAP25		Histone deacetylase complex subunit SAP25	Coggill P	pcc	Jackhmmer:Q8TEE9	Family	SAP25 is a family of proteins found in eukaryotes. SAP25 is a core component of the mSin3 co-repressor complex whose subcellular location is regulated by PML. mSin3, the transcriptional co-repressor, is associated with histone deacetylases (HDACs) and is utilised by many DNA-binding transcriptional repressors. SAP25 is a nucleo-cytoplasmic shuttling protein that is actively exported from the nucleus by a CRM1-dependent mechanism. It binds to the PAH1 domain of mSin3A, associates with the mSin3A-HDAC complex in vivo, and represses transcription when tethered to DNA [1,2].	27.00	27.00	155.10	155.00	19.80	14.90	hmmbuild  -o /dev/null HMM SEED	204	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.49	0.71	-4.81	5	25	2012-09-25 13:48:04	2012-09-25 14:48:04	1	1	22	1	14	27	0	186.90	67	79.86	NEW	MTLLAPWDPNYEAKAGPQLVWGPSCGSGASFSGRTLCHPSFWPLYEAuSGRGhRPps...PuuGHQsGEQAPRDAGFPVMCsEDVFLLDPLLPsGQRVPLYLSEAPQQVMGSLKLLLPPPIMSPpVhPhPSpspGCSTAWLSGPELIALTGLLQMSQGEPRPuSSGuP..ussussPussS-sPusS...GGP.SCSHuTDPSLPpTPDTHCP	MT.LAPWDPpYcAKAGPR.VWGsuCuSGASFSGRTLCHPSFWPLYEAASGRuLRPhs...PuTGH.NGpQAPtDAGFPVMCsEDVFLSDPLLPpGQRVPLYLSEAPQQVMGSLKLLLPPPIMSPhVLPp.SsspGsSTAWLSGPELIALTGLLQMSQGEPRPuSS..uus..ss.sGsPsssS-.PuPs...Gus.SsSpssDsSlPtTPDsp.............	0	1	1	2
+15333	PF15477	SMAP		Small acidic protein family	Coggill P	pcc	Jackhmmer:G2TRQ9	Family	This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.	23.10	23.10	23.60	23.60	22.60	22.60	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-9.49	0.72	-3.71	65	309	2012-09-25 13:57:31	2012-09-25 14:57:31	1	6	154	0	194	283	0	74.90	31	22.26	NEW	p.W..ssu...s.......h...G.ssp+p..pKFhRLMGupK.......................tsss.s..ts......p..s...............stu....tsppcppclppcLEpQaptu..hph+......G..p+.+..GLG	.......................Wcss...sF....s..sc-pp..tKFh+LMGstc..................................................csss.sts.......p.s...............................sth....tstcppcclppsL-pQYptuhstp.......tpp.+...GLG...........................	0	51	78	127
+15334	PF15478	LKAAEAR		Family of unknown function with LKAAEAR motif	Coggill P	pcc	Jackhmmer:Q8TD35	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 119 and 235 amino acids in length. There is a conserved LKAAEAR sequence motif.	27.00	27.00	37.50	36.10	24.00	19.60	hmmbuild  -o /dev/null HMM SEED	137	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-10.76	0.71	-3.91	8	31	2012-09-25 14:00:14	2012-09-25 15:00:14	1	2	25	0	19	27	0	117.80	48	65.91	NEW	.PKNWpphospcLpKhuPQpRSRYLAYE-ssK-lt-..shuhshKRl+-..hptch.scPR.shsp-h.l-+-+ps+LIGQLKAAEARNRlRlMRLRYpthRApElpHLIuCQPTAhKAlRLEuhlPPplcsspssDhLDKh-	...........s.s+shhtho.ptLtth.stp+p+hhhatc..ccl.t..thuhhspcShE.........sh+h.sDPR.shopslplssc+pspL.lG.LKAAEARsRlRshRLRYs+hR.A-EIshLIppQpSARAAIRLEhFLPPQLKPs+IsDPLDRpE................	0	8	9	11
+15335	PF15479	DUF4639		Domain of unknown function (DUF4639)	Eberhardt RY	re3	Jackhmmer:A6NN90	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 161 and 601 amino acids in length.	27.00	27.00	29.70	29.20	24.20	23.80	hmmbuild  -o /dev/null HMM SEED	576	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.08	0.70	-12.86	0.70	-5.86	12	53	2012-09-25 14:32:57	2012-09-25 15:32:57	1	2	36	0	32	52	0	368.20	40	88.05	NEW	QERQsR.DRGVTRSKAEKARPPTVPVPQVDIVPGRLsEAEWhALhALEEGEDVVGDILADLLARVMDSAFKVYLTQQCIPFTISQAREAMLQITEWRFLARDEGESAVAEDPTWGEDEEPhACTTDuWAQGSVPVLHAPAs.GlE-pFQuE......D.GusDph.LGRSWhsRGSQE.hpShE.SsEh+hh..susssTsELFQEAGPtssLEEsDsQtp...........uth.....AtS.ssShQ....SsEhssstSPcsSLELo.VASsQAsscRuQPhuSpLSLEDLYhChPQ.DAAGDRL.chcpEGhPplASss..ussShGssT.hsPSsShps.ppPh......ss.p.Rhs+KssssRLDPARLPRHWVRPLAEVLlP............DSEs+PLEsYRGRpRspKTcA...pAtPQusssGsRVSsAsF.....FPLpPusPFRALGss...tlp.PTLNLu.sSPshsSKlPFPSPGlRFLssHPshPDVARSPSPKLWPuAKWPSGWEtEAELLGELWAGRTRVPPQGL-ssD+..cuQDsttWPpssPQVLEATSQVhWKPhLLPEAhKLAPGVSMWN.oTQVLLSS....uVPppEcccGosssP....-QpPIQTGsPKP	.................................................s+o+sEKs+........s.ss..VP....pV..D.......IVPGR.lsEuEWhshhshEEGEDhVuDIluDllscVM-ssa....clYLspQslPFTlsQA+-AMLQIsEWRFLARDEGEssVApDP........TWsEDEE.P.sssTDuWAQGSVPV..Lpsss........u.cp..........hpsp..............................p.tt......ht...hht..ptSpp...............................t.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................	0	12	13	15
+15336	PF15480	DUF4640		Domain of unknown function (DUF4640)	Eberhardt RY	re3	Jackhmmer:A8MTZ7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 306 amino acids in length.	26.00	26.00	26.70	26.70	19.10	18.60	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.17	0.70	-11.97	0.70	-4.84	11	31	2012-09-25 14:47:49	2012-09-25 15:47:49	1	2	21	0	18	37	0	230.50	51	92.00	NEW	SSscSNLSLSVGYFPCE-TaSYE-TsSpEDssS.ssSlHFLPPIQGoWpTESTtRLhtRRDQlpDsPEQFCKLSITLAWDlDVuSssSDSluNWDLsucsQWhDKaPE-cTpLTLuKLDsLVQKLEpFLENcKssccDDSlhPESsQE......EDhpLsSSoPPchAQl...SHQEHsoCQDLPph+s.ENE-lhQhPphP.RLpcpE.sc.hoQuoGSptssosETSSlSoGpsEc-s.....ssSshQsLSCLNFtW.VFRWLRpQVhSSLhRRccPp.cATcusHphAtK+RhSaRuKRIQPQE	...........................SpspSNLSLSVGYFPCEDT..hE-TsuhED.ssSpss.SlHhlPPIQGsWtTEphtRhhpRpDQIQDpPEQFCKLSIhLAW....DlDluSsso.DShsN........h.LsucNpWhDKhPc-cTpLoluKLssLVQchppFLEN.Ks......DDulhPcosp................cDhQLsouSPPchsQs...SHQEassC.QD.s.hps.cNcclh..........t.Eh.........sphhsQuTuSQpTsssEhSSl.StpPEc-D.....TsSpTps.sCLNFtW.sFpWLRpplhSsLhRRccP..pATcusHp.A.p+Rh.aRuKRIQPQE..........	0	2	2	2
+15337	PF15481	CPG4		Chondroitin proteoglycan 4	Coggill P	pcc	Jackhmmer:O16883	Family	CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification [1]. The family is rich in conserved cysteines.	27.00	27.00	28.00	27.00	26.50	26.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.52	0.72	-11.24	0.72	-3.65	15	49	2012-09-25 14:50:01	2012-09-25 15:50:01	1	3	10	0	44	41	0	91.60	21	27.44	NEW	sCh+pChsslhcslpthhp.hsp..ps-phcslCspaspuppCl.pp.ttpCcp...phFsshTSuhcahCl-pc-sassphsClptssuslppcC-ppCpsp	....................C.ptChpshhp.hpthht..tp.......shpphpplCptasputpCl.pp.ptpCsp...tthhpthosuhcahCs-pct........tFppphsClst...ss.h.ptCcppC...t.....................	0	17	22	44
+15338	PF15482	CCER1		Coiled-coil domain-containing glutamate-rich protein family 1	Coggill P	pcc	Jackhmmer:Q8TC90	Family	This is a family of coiled-coil family proteins found in eukaryotes. Proteins in this family are typically between 160 and 397 amino acids in length.	27.00	27.00	38.10	37.50	23.20	23.00	hmmbuild  -o /dev/null HMM SEED	214	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.68	0.70	-11.68	0.70	-4.70	7	24	2012-09-25 14:58:47	2012-09-25 15:58:47	1	1	22	0	14	25	0	187.80	59	55.95	NEW	Tlsp+EDPLNL........GG..GWApSssLpoWSSCHRRRRGAPhY+RRaRYGPKsEYEPPRKQPKQQHuPGsWFQ.PPRpP.h.VhSNWG+WGGPW+PPPssFhKPPs.VQhIRVYGLpPlCL.CCCSCWsGPWNPGWhRPPGRKKRWGRR...GRGLRRpPRRShPRuPP...sDLShLLRPVNLYGWRAPGMRAPpNTTQFIMNQIYEDMRQQEKLERQQEALRAQQA	.................................Tlsp+EDPLNL..........Gs.GWApSssLpoWSSsHRRR.GAPhapR..aRYuPKsEYtPPRKQPKQQHuPG.WFQ.PP......lhsNWGphGGPW+PPPssFp+..s.VQhhRVYGLHPLCh.CCCSCWsGsWNPGWsRPPGRKKRW.GRR...GR..GLR+H...PRRS.P.RsPP......sDlSpLLRPVNLYuWRAPGMRAPpNTTQFIMNQIYEDMRQQEKLERQQcALRAQpA........	0	1	4	6
+15339	PF15483	DUF4641		Domain of unknown function (DUF4641)	Eberhardt RY	re3	Jackhmmer:A8MYA2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.	27.00	27.00	122.20	85.00	19.30	18.80	hmmbuild  -o /dev/null HMM SEED	445	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.59	0.70	-12.43	0.70	-5.77	16	39	2012-09-25 15:14:33	2012-09-25 16:14:33	1	2	19	0	19	45	0	376.40	41	87.67	NEW	pEGcPGo.PsD-cts.slD..h...Lu..-psAAIhp.LoshpshtVp+pPSPEus....ss-suslWA-lEsGPuuRGA.u.............SssEup.pASAusLalsGPttGRAWsss+Ruop.SRhshsss.QpssscG.sthsS-sE..SSDEho-lQhMRVoIphKc...GuQAKssSsccsuDosRHosspsREsFlpVPGshLoSAsRGLoss.lERQA.sGEh-sS...s.KKhpShlWGKtsuRPSasGuAs..................uGuLP+uoPR+KhAQEKKSLGsASchsLGR...sFPsWGQRlSAuPsEPATFPPlSGVsLLG+Sp+.u.ls.tPKpsKpsusGKKsu.u++sREsps...sutEDNDPsRDssspuQlPTHRPtss.....shpsH+GEhSSG-sNhRusQsPGsSpssALSQuulhPRtsAsSGD....QpPss+ssRP-....R.QQpPPGtQGCPRClhLQ+EI-DL+-QLuuhpuLu-+FQ	........EGpsuo.PsDcpts.sl-..h...Lu...pssslh..ho......lpc.Ps......P-ut....sttsus.hssh-sGsstRuuhu.............ussctp.psouushahsG.t.tGRAWtsPcRusp.uRhshp.s.Q.Ps..........o.c.s-..SoDE.s-l.hh+VslphKc...ssQA+ssu.pc.s-ssR+sshps+-sah.lPushLoSsspGLoss.hER.u.sGE.-sS...s.KKh.uhhWGK.tsRPShsssss..................sGsLPpsssR+K.sQEKKS.ussSphs.G+...sFPsWGpRlpuAP.-PAThPPlSGVsLlG+op+.......sKpsKptssG.KKss.u++sREsps...sstEDN-PsRD.sspuQlPTHRst.s.....shsha+GEhSSGD.NhRusQlPGsSp..uhSptslhPRt..uPSGD....Qps.scsstPc....R.QQ.s.GspGCsRChhLQ+EI--L+-QLushp.h.t...........	0	1	1	1
+15340	PF15484	DUF4642		Domain of unknown function (DUF4642)	Eberhardt RY	re3	Jackhmmer:A8MZ97	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 196 amino acids in length.	27.00	27.00	88.90	88.80	20.20	19.80	hmmbuild  -o /dev/null HMM SEED	156	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.29	0.71	-11.13	0.71	-4.25	11	23	2012-09-25 15:24:08	2012-09-25 16:24:08	1	1	20	0	13	25	0	142.90	58	83.00	NEW	Capu+pcEETEKsPCTsuNsGEDC..sAANsEpsNscDQEK.hlhphhshshPhRPGILVQRpsK-.hsTsLtNpc-hEsccEs+hK-+QcPcsutEssQE.sD.lpKs.Isloto.SVs-sQKRPLKGVTFSREVIVVDLGpEa.PsPRSYTREHKERK	.......hhpsppscETcKsPChssstG.cC..sAAps.psNstDpE+..llhQlhshssPMRPGILVQRpoKEshsT.PL-N+c-hEsEEEsphpEKQEPc.NAGEsuQE--D.LQKh.IslT+TsSslEsQKRPLKGVTFSREVIVVDLGpEY.PsPRSYTREHKERK	0	1	1	1
+15341	PF15485	DUF4643		Domain of unknown function (DUF4643)	Eberhardt RY	re3	Jackhmmer:A8MZF0	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.	27.00	27.00	163.60	129.50	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	284	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.18	0.70	-12.07	0.70	-4.92	10	19	2012-09-26 07:55:05	2012-09-26 08:55:05	1	2	16	0	10	13	0	231.20	53	73.08	NEW	spDuDtuPssPosQPLlPVAHIRPLPsuAQ......ssSPpPEEPsV.......s+sPPuFQAS...VsREuusRVVV.PIAP..ThRSsuPSsaSlsPsuP-up+lEc.Ph....AuPusEAcpVsSsstuSosu.sSsPHPsPsP+VAPKP.............+hSGWTRLKKQLhEEAEEP.aPp.ptsLEsp..t...ppEsstP.........ss+sPsSRAS+MWDAVLY+MSVAcs.ps+.sGPssuE+oh..............uul..oRLP.FLYRPRFNARKLQEAA.RPPPTlpsllEL........sPpPKNFNRTAsGWRL	.....tDuDtsPssspsQPLlPVAHIRPLPTusQ......usSPhPEEPsl.......sRPPPuFQAS...VsREuusRVVV.PIAP..Th+S.tsSsaShsPhuPttcplE-.Ph....AuPAsEscpVsSsshASuPs.sSGPHPsPsPKVAPKP.............+lSGWThLKKQLhEEs.EP.hPt.p.sLEsp..t.....cssts.........sspsPsSRAS+MWDAVLY+MSlscs.psp.sGsssup+s...............usl..oRLP.FLaRPRFNARKLQEss.RPPPTlpsllEL........sspPKNFNRTAsGWRL..	0	1	2	4
+15342	PF15486	DUF4644		Domain of unknown function (DUF4644)	Eberhardt RY	re3	Jackhmmer:A8MZG2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 191 amino acids in length.	27.00	27.00	54.80	54.60	16.90	16.90	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.07	0.71	-4.28	7	34	2012-09-26 14:07:21	2012-09-26 15:07:21	1	1	24	0	17	35	0	151.20	72	86.36	NEW	.AVShAtG+PuHsDsPPNIYEGGLGspQpQCPSsQGSKPKNFRLRHLRGLALYLPuHMQPAGQCESHWLuRLMuGGCLPp....PE....GsAWsLc..LPQGsLuPsNShCoAhLEAplPRDSLGsTASSSShDPsKGs.sQPuPsEG.GlRPKRSWGshEEuhCPLCKR	....................DAVS.AtG+PuHPDsPPNIYEGGLGuQQp.QCPSAQGSKPKNFRLRHLRGLALYLPGHhQPAGQCESHWLGRLMAGGCLPp....PE....GoAWsL.D..LPQGTLGPGNShCSALLE.ApLPRDSLGsTASSSSMDPsKGs.sQPuPsEGLGLRPKRSWGs.EEshCPLCKR....	0	1	1	3
+15343	PF15487	FAM220		FAM220 family	Eberhardt RY	re3	Jackhmmer:B1ANY3	Family	This protein family is a domain of unknown function which is found in eukaryotes. Proteins in this family are typically between 217 and 277 amino acids in length. There are two completely conserved residues (S and L) that may be functionally important.	27.00	27.00	41.40	38.80	22.90	22.20	hmmbuild  -o /dev/null HMM SEED	278	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.70	0.70	-5.03	11	40	2012-09-26 14:59:18	2012-09-26 15:59:18	1	5	26	0	18	42	0	241.00	47	83.03	NEW	+DtRsslslsLhsh+suct.......DsD+Lhpslppp..............pcssh...........p-..ssshsspPsst.pGsSptpth.Ssch+pstShu..u.lh+uuppsLP....l+posptsSsuuuups.................cuVsh..tP..tcE.pFssl.ssls-AllsDWLt+ss+ssssh+sWsppG-s.......WlStlPspQKl....hEhGllcDE..sAhhcGlusc.lp.ssLculLSAllppYP..psLhssEs+pVFL-hLpshhScpThEYKKhLSsl+soosshQlshhLLAlpuFsLh	...............................................................RD+RGsLGoCLApVptutGu......DSDKLshuLKKR...............EusaP..........uD..sPSWhsKPsV..DGNSQuEuL.SlEM+ps.StA..uLhLHuGsslLP...al+ESlRRNsASAAo.S.................pAVuLhsAP..oE..pFApVuCussEALh.p.DWLutusRATcupRGpC.KGEs........hlScLPp+QKL.....EMG.hpD-PPsAhscGLGoE.LE.SsLHSlLSAsL+shP..-VLLs-ETKplFLDpL.............pPhFScQThEaKKML...KsTocsLQIsLuLLALpsFpLh....................	0	8	9	11
+15344	PF15488	DUF4645		Domain of unknown function (DUF4645)	Eberhardt RY	re3	Jackhmmer:B1ATL7	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.	27.00	27.00	52.20	52.10	20.00	19.60	hmmbuild  -o /dev/null HMM SEED	294	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.96	0.70	-11.85	0.70	-5.25	7	21	2012-09-26 15:18:55	2012-09-26 16:18:55	1	1	18	0	11	21	0	273.50	64	98.88	NEW	MAClENVLGGHAsSPhsVss-cNuspEs+..sh.LQC.SSh.+...-DsEsWG+PpVsLRPPhsVLoDLsRpQLEpPSERTGSCIPVsssRAL+pPYsPPPAlAEESLATAElNSSEGLAGhRQcGQDSI.NVSQEFSGuPPALMlGGTRVSstGTERGGNNA+hYssLPRGQGFFPPRGPQlRGPPaIPTLRSGIhMElPPGNsRMAs+c+LA+VSFP.GuPRHPhcNWPRP..lPLSSSTsGLPspooAHCFIPPp.PPSFNPFLAMPhAFAPPPlFuPPLPSYFupFPShGMPsPussN	..MACIENVLGGHAPSPhlVssDcNGNpE.+..DhPLQC.SSh.c...DDAEsWGpPpVsLRPslNVLTDLspcQLEtPSERT.GSCIPlcS...RAh+HPYGPPPAVAEESLATAEVNSS-uLAGWRQcGQDuI.NVS.EhSGuPPALhlGGT+VsNtGTERGuNNARLaVALPRGpGFFPPRGPQVRGPsHIPTLRSGIhMEVPPtNTRhAs.+t+LAHVSFPLsGPpHPhcNWPRP..lPLSSSTPGLPsCSTAHCFIPPR.PP.FNPFLsMPlsFAPPPIFGPPLPSYFupF.ShGMPAPAssN..	0	1	1	1
+15345	PF15489	CTC1		CST, telomere maintenance, complex subunit CTC1	Coggill P	pcc	Pfam-B_19246 (release 26.0)	Family	CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. Mutations in human CTC1 have been recognised as contributing to cerebroretinal microangiopathy.	25.80	25.80	26.50	25.80	25.30	21.30	hmmbuild  -o /dev/null HMM SEED	1144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-13.30	0.70	-13.98	0.70	-7.22	13	86	2012-09-26 17:22:21	2012-09-26 18:22:21	1	5	45	0	49	95	0	701.10	36	91.14	NEW	sLPLSYSFVSVQ-L+TaQ+LPCCSHLSWSSosYQAWApEAt........PsGsPLPREpLLLLGTLTDLsuDhEpEsRsGuLYVRDNTGsLsCELlDLDLSWLGHLFLFPoWSYLPPAphsSst...pGHLELhusPVPVhPLslSPsPhTPlPVLYPEpASpLLphRsKhRsspsNLAG+LVRlSALV+oppKsYFlLSLG.t.s....sAsopVslIVQlPuQLVWH+ALpPGcuYVLTpLRVoplRG.+ppRVWsTosSScLhsLcPpsVREhEl-htt..........shL-AsspshstPosSQDt......t.psLlRpS+lLsYpGTVTcVLNpsAGLYELDGQLsLCLAYQQhpuhRRVlRPGssLELpDVHLLQSlGGGTp+PVLAsCLRGuVhLpuFSppc.PtspsSaps.GAuLaEpLlWE+pLGLPLYLWAs+ALcELupKLCPHhLRHcQhLpaSuPGsPuLGLQLLAPsL-lLtsP.ssstRNsaoEILEEPH+CPLQKYopLQTPsSFPTLssLpEE..uQ..p+AWASFDP+uLLPLPEAuHLTSsQLNpRLAWSWlCLhPosFpPA..VLLGVLVASScKGsLQLRDpo..GSLPCLsLscspQ...PhhDs......plIGCLVRlE+FQLVlERpV+SsFPSWKELshssFIQK+pARVYlQFhLuDALILsVPRs....ssssso.Ppst.........................spPEGPphGQSRLFLLpHKEuLMKRNFssssusSs-sspPsLSFpVsGoWLGGTQR.KEGouWGPPEspt-...EspDQKVhLlFhGSSVRWFtFLHPGpVYRLVAsssssPtlhcttsuSslSpRsLELuussSCLTVQc-WTLEhtuup...DlsssLshs+sLs..ESSLo-LLSuN.ssSLVSFS.AEILSR...sLCpslssshhh+s........Gsusus+psVKLTVAL-sADschPPH.LDVYIE-PHhPsPLGLLPGARVaFSpLEK+VSRupNVYCCFpsoThVpVLSF....PsEoshSsPLPHIaLAELhpGspsPF.pAosSCHlVsVhSLpLhWVCAHCTSlCsQG+CoRQuPsCPoQooVSQAsI...RLLVEDGTAEAsVTCpsHpVAsALGLsPoEWsuLL-tVRsPG+VALQFpGsGA..QsESsucs--PLohFLpTL.CTSsuVLRPlhLoFcLER+Po.clhPLEPPRLQRFQCGEhPhLTRVNP+LpLoCLSI	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................shhlpa.GhlTtllp...s.ulY..hDt..plhLChsa..h.t.hthhR.Gsplpl.psHhh...t......h.h..C.hutl.l.taot...s..............................................h........................................................................................................................................................t.......hl.Gh...tt.pu.h.l.Dtp..ttl.Cl......t...s..ss.......................hhushl.phpch.llhEp...sthso..................pph.hYl.h.hscshll..s.s..................................................................................................................p.......h.hhh.thchl...............................................................................................................t..h.......sh.l..t...p..........................h.phhtsp....sphlshp.s.h.......hh......................s...t..h..thtltlphtt.t.....lplYhp.sths...hGLLPGstlhhpthp++lS+.ttslYsp..s.so.lplhuh...............s...............PhhhLh....ttt.............u.h.splsslh.lpl.WhCshCt.........slh.ts.t...........C........C.s.tsh.ps.h...phhh-.DGoupAhh.hps.t.lh.hLtls...htsl.t.h...Gpl.............................................................................................................................................................................................................................................	0	16	19	31
+15346	PF15490	Ten1_2		Telomere-capping, CST complex subunit	Coggill P	pcc	Jackhmmer:Q86WV5	Family	Ten1_2 is a family of primarily plant and vertebrate telomere-capping proteins that is evolutionarily related to the mostly fungal family of Ten1, Pfam:PF12658.	27.00	27.00	27.90	28.10	26.20	26.00	hmmbuild  -o /dev/null HMM SEED	118	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.19	0.71	-10.21	0.71	-4.51	29	82	2012-10-03 20:18:03	2012-09-27 10:45:23	1	5	69	0	56	78	0	112.70	36	82.16	NEW	hspsGshhhh.E.l...uusth.pGpolRshGRLppYDhtpuhusl...........ssspppltVsTph..lcshps.........plGSlY.hlGElppp...pssts..............llpARVhpsVDGlDlsLhcpAlp.pRpahpc+	....................................h..psGhhhh..E.l........uus.h.pGtolRshG+LptYDhtpuhssl............tssppplhVsTph....l.cshph.........plGSlY.hlGELptp....pssss..............................llcARVhpsV-GhslsLhcpAlp.pRpa.pc..........	0	19	30	42
+15347	PF15491	CTC1_2		CST, telomere maintenance, complex subunit CTC1	Coggill P	pcc	manual	Family	CTC1 is one of the three components of the CST complex that assists Shelterin to protect the ends of telomeres from attack by DNA-repair mechanisms. This family largely represents sequences from plants species.	27.00	27.00	35.20	39.70	24.10	19.90	hmmbuild  -o /dev/null HMM SEED	291	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.97	0.70	-11.89	0.70	-5.40	11	18	2012-09-27 10:28:16	2012-09-27 11:28:16	1	3	14	0	13	19	0	276.80	36	26.22	NEW	sslspPslLsGpLtLs.....ots.s.sspppChthoD..........uuusVCCsllch-hsslG+cIpVhuWNalPstp......ssG.....hLEllchphs-sss........hs+...........ssslcolPLt.....ssppssuKsRhslpGlLcSVSPlhslPpt.stpsu...............................ss.hGFlsplhsCtCc.hhtt.............psHpFsp.hh.........VYFsGu.uupW+PVLs+hVGphVslSGLKKKlVhlGccsSpl.haVuTpcohlthss.t.phh...hpps.h.h.GcChGpYpGlVoGlYhQGhllELDc....pVWLLlTDp.Ls....ssHuLRVGAl	......sPlspsslLsGsLsLP.....ups.s.sspppChphSD..........uuuoVCChlLcF-.cAlG+cIpVLuWNaLPshpp.....uuG.....hLEllcW+hs-sss........hsc...........suhlpolPLt.....ssppsctto+hpVhGVlcSVSsVhsVPptsttusus..............................sN.sGFlsclhsCtC+.hph.............spsHpF-tphF.........VYFssu.uupW+PVLs+hVGc.VslSGLKKKlV.ls+csShh.hhVoTccohlphssst.thh...hsps.....GcChGsYsGhVoGlYhQshllELDc....pVWLLlsDQhLs....ssHSLRVGAh..................	0	4	7	11
+15348	PF15492	Nbas_N		Neuroblastoma-amplified sequence, N terminal	Coggill P	pcc	Jackhmmer:A2RRP1	Family	Nbas_N is an N-terminal family of metazoan sequences. This domain lies at the N-terminal of several WD40-containing proteins. The human protein is over-expressed in neuroblastoma cells [1].	27.00	27.00	27.00	29.90	26.90	26.70	hmmbuild  -o /dev/null HMM SEED	282	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.14	0.70	-11.78	0.70	-5.30	4	74	2012-10-05 17:30:43	2012-09-27 13:19:37	1	8	57	0	54	74	0	243.70	51	15.14	NEW	WHLVLASNGKLLAsVQDQCVEIRSA+DDFGSlIGKCQVPKDPNPQWRRVAWSHDCTLLAYA-STGTVRVFDLhGSELFVIsPusSFPGDhSYAlAGLlFLEYpuSAQWSAELLVIsYpGpLKSYLV..SVGTNQuFQEsHoFSFSSHYsHGIToAIYHPuHRLLLVGGCEou..-sGhSKASSCGloAWRVLSGSPaYKQVTShEDDlus.sp+pGhh+h.Sh+haSRpupEpDGVF+MSLSPDGTlLAsIHFSG+LSlWsIPSLKQpGpWtQsEQPGaD-INPEW	...............................................................................W+llLu..ssGKLLAslQDpslEIRSA+D-FsSllGKC.Q.V.PKDPpPQWRRlAW...S...DCTLLAYA-SoGTV+lF..DLhG.oc.LF.lIsP...u...s....o....h...s....G.....D........l....ShAIAGLlFLEY.+.u.S...A...QWSAELLVIsYcGpL+SYLV..SluT.NQuaQEsHs.FSFuuHYspGIsoAlYHP.uH.R...LLL.....VGGCEss......-..suh.S+...AuusGLoAWRlLSGSPYYKQ.Vo.sttDplsssspphulh.+..hh.s...........hphao.+p...spcpDGlF+MSLSPDGplLAsIHFSGcLSlWslPSL+.ptpWp.sEQPGaschsP.......................	0	18	22	35
+15349	PF15493	YrpD		Domain of unknown function, YrpD	Coggill P	pcc	JCSG:Target-418961/SP17457A	Family	This family of proteins is found in bacteria. Proteins in this family are typically between 236 and 351 amino acids in length. The member from Bacillus subtilis, UniProtKB:O05411, is named YrpD.	26.40	25.50	28.00	26.20	25.90	23.80	hmmbuild  -o /dev/null HMM SEED	208	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.58	0.70	-11.55	0.70	-4.69	8	35	2012-09-27 13:15:57	2012-09-27 14:15:57	1	1	27	0	9	35	0	192.80	53	73.28	NEW	AstlscGIGGRshlNSo....GuhlsTKlpLPosspls.....ssGssYIYoGF..oG...........ssEuDhGLpYS.......ssYsV..WKP..hhKlGucsppsstYlp.....GhschTYpNGF+PGosVQLTlYKNhNGsT.....RholhGT..........ssDsYsspIIpElssoNluSlopWKhLATlAsossstpp.......hpupFoNIslDupuhTPV......lDspDaApVTl.SGNoVolsV	..........ASQLscGIGGRAYLNST....GulhsTKIpLPoohpl.......SsuTsYIYSGF..oG.........GTEADIGLQYS.......cpYNV..WKP..lMKVGSKspsp..YlE.....GtspFTYsKGFRPGSTVQhTIYKNLNGNT.....RhThWGT..........NNDGYTGRIIoElptTNlGoISKWKsLATlAsotpsQp.h....usFSTuFsNITIDNKAlTPV......lDTQDFAKloV.SGNsVohSV........................................................	0	2	3	3
+15350	PF15494	SRCR_2		Scavenger receptor cysteine-rich domain	Coggill P	pcc	Rawlings ND	Domain	SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.	27.00	27.00	27.00	27.00	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	98	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.75	0.72	-10.44	0.72	-3.75	47	411	2012-10-03 20:35:02	2012-09-27 15:58:16	1	29	62	0	195	605	1	92.80	28	15.67	NEW	utshlLpVhsstpssWhsVCp-sWssshGptsCppLGa.....p.sappuhslsshpht.uppFhpL.......ssshs..ltpthp....pssCsSuplVSL+Ch.-CGhps	.................p.lLpVhsstpss.WhsVC.tD.sWspshu.ptsCpplGat.....p.s..tp...p.s.l....t.l.....s.s.....h.p.t...............p.ahpl..............ssp.s.s...l.phh.........pp...sC...sStp..l.VSLp.C.....t..CGhp.s...........................................................	0	14	28	87
+15351	PF15495	Fimbrillin_C		Major fimbrial subunit protein type IV, Fimbrillin, C-terminal	Coggill P	pcc	JCSG:Target-417041/SP13489F	Domain	Fimbrillin_C is a C-terminal family of major fimbrial subunit protein type IV proteins largely from Bacillus species. The family is associated with family P_gingi_FimA, Pfam:PF06321.	27.00	27.00	27.10	27.10	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	85	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.97	0.72	-10.01	0.72	-3.83	35	193	2012-09-27 15:57:20	2012-09-27 16:57:20	1	3	69	0	26	187	4	85.60	27	16.60	NEW	lphYpsGls.YYphhI+H..Dstssssh.................thuca.GVVRNshYslslsslps.GpP................sssssspss-cscsaLslcIpV.PWshhsQsh	............................hY.puhs.YYphhlcH..sstsssth.................thhca.ulVRNNhYplslsslps.GpP..............................tssssssss-ppp.s.alslplplhPWshhpps.........................	0	7	23	26
+15352	PF15496	DUF4646		Domain of unknown function (DUF4646)	Coggill P	pcc	Pfam-B_61885 (release 26.0)	Family	This is a family of proteins largely from fungi.  The function is not known.	23.10	23.10	23.10	23.50	22.90	22.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.77	0.71	-4.06	20	64	2012-09-28 09:46:54	2012-09-28 10:46:54	1	1	49	0	50	68	0	125.70	22	31.09	NEW	PsuFuRsPssslsYs..sF.pPhplhuh..usp....LssGFshl........PpsL.ssHDVsppDWtRFlcDlptAuhhospp..hhuuhhPlh.hls.........lsuhhhstthccthcs+c....sshlsclI-hWNpsFFpPRt	...........................................h..tshpl.oh..ssp......lssGFsh.........sphL.hppcVs.p-WppFhc.......-lstAspLostp.....phstss.uhs.shhlu....................hG...hsuhhsu+..shcptt.tcp....................puplpshlcpWNpshFpsRt............	0	19	27	41
+15353	PF15497	SNAPc19		snRNA-activating protein complex subunit 19, SNAPc subunit 19	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O75971	Family	SNAPc19 is a family of proteins found in eukaryotes. It is one of the five core components of the snRNA-activating protein complex or SNAPc that helps direct the nucleation of RNA polymerases II and III. The core RNA polymerase II snRNA promoters consist of a single essential element, the proximal sequence element (PSE), whereas the core RNA polymerase III snRNA promoters consist of both a PSE and a TATA box. The SNAPc binds to the PSE of both of these. SNAPc recognises the PSE sequence common to all human snRNA genes, irrespective of polymerase specificity. SNAPc is also known as the PSE transcription factor (PTF) or PSE-binding protein (PBP). The human SNAP19 and SNAP45 subunits are dispensable for transcription in vitro and are not as widely conserved as the other three, SNAP190, SNAP43 and SNAP50, suggesting that these vertebrate-specific SNAPc subunits may have adapted specialised regulatory roles for snRNA gene transcription [3].	27.00	27.00	29.10	29.10	26.20	26.90	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-10.22	0.72	-3.78	22	69	2012-09-28 13:02:45	2012-09-28 14:02:45	1	1	56	0	43	67	0	82.80	46	84.02	NEW	EL+pEEcpLL+lhsslp-QLN+LKVEELtL+Shlsspp..tps.sttss.............sppp.shhh...plDsp....spINpppLp.Lshtssh...........pcptEEEc-sD	....EL+KEEEsLLRl+ssLpDQLNRLKVEELtLpShlsupp..sph.ss.ss.............sppphch.h...tl-sp.........spINQppLc.Lshtsph............cp.EEE--p...................	0	7	10	24
+15354	PF15498	Dendrin		Nephrin and CD2AP-binding protein, Dendrin	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O94850	Family	Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.	27.00	27.00	109.60	47.40	20.10	19.50	hmmbuild  -o /dev/null HMM SEED	657	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.51	0.70	-13.28	0.70	-6.02	4	28	2012-09-28 13:42:25	2012-09-28 14:42:25	1	2	22	0	17	28	0	508.80	67	94.99	NEW	MDhQASaWApGPQSRTCt.RPGSPEPPPRRPWASRVLQEATNWtsG.PsElRAREQEKRKAASQEREAKETERKRRKAGGsR..RSPLGp......sR.EPRNu.RsAQPsGhssPsRPERhG.sGRsPRPuAQPQuDPG.AAWAGsWuGRRPGPPSYEAHLLLRGAAGTAPRRRWDRPPPYVAPPSYEGPHRTLGoKRGPEhspuPssuAPAPT.suRTEGGRsKKRLDPRIYRDVLGAWGLRQGRGLLGGuPGCuuAtsR.EhuKGuuEKSsGlssAGLNSuuDu+.QucssuuPGsptA.AtuAsuosusPRssPRsR.pL+GScEGKEupEQ.WLPcCWlPSPK+QPsRHSQTLPRPWAPGGTGW+ES.GpR-G..suPch.EsWKtTRRAHTLPRSuRGsAttEGVFVIDATCVVIRSQYVPTPRTQpVQLLPSGtsRssGDu.u.PpPu.cEEGEtAuAhsSsCQKLL.SSRlhcQ.StG....htpEAEuGpstDSSL.cERuS+lLGhPlGEVsltsAP....uQPGSPE+sA.GsAAsssAuss+GSE.ssusPRRAGsGWARTPGPYAGALREAVSRIRRHTAPDSDSDEA.tELSV+SGSSDGSDTEAsGASWpsEpo.PthusspPt-GGKTAELpDSIREILDVISQsEEuLFtscDoptsPQGsRc	...................MDhQASaWARG.QsRTCtPRPGSPpPPPRRPWASRVLQEATNWRuG..AEsRAREQEKRKAASQEREAKETERKRRKAGGAR..RSP.Gp......PR.EPRNA.RsAQ.sGhsus.RPERhu.sGRsPRP...sA.PQusPG.uAWAGPWGGRRPGPPSYEAHLLLRGuAGTAPRR.RWDRPPPYVAPPSYEGPHRTLGTKRGPt.SQsPsSSAPAPs.sARTEGGpsKKRLDPRIYRDVLGAWGLRQGpGLLGGSPGCusu+sR.EsuKGssEKS.GLAAAsLsSGucuHsQA+.ssGusuochsPAGuAsussssPRPsPRSR.HLcGSpEGKEG.pEphWhPKCWlPSsK....KQPsRHSQTLPRPWAPGGTGW+ESLGhtEG..sGPEsLEsWKsTRRAHTLPRSSpG......sutGEGVFVIDATCVVIRSQYVPTPRTQpVQLLPSGssRlVGDuPoQsKPs.KEEGEGAsshPSsCQKhL.SSRl.HQPutG....+shEAEGGcsuDSSL.EERssRILGLPssEVNLpDAP....oQPGSPEHpALGPAAsustutscGSE.ssss.RRuGtGWARTPGPYAGALREAVSRIRRHTAPDSDoDEA.tELSVHSGSSDGSDTEAsGASWRsERT.P.hus..spPpEsGKTAELSDSltEILDVlSpTEE.sLFtscD.+tT.QGsRc......................	0	1	1	3
+15355	PF15499	Peptidase_C98		Ubiquitin-specific peptidase-like, SUMO isopeptidase	Rawlings N, Coggill P	pcc	Jackhmmer:Q5W0Q7	Family	Peptidase_C98 is a small family of SUMO - small ubiquitin-related modifier - isopeptidases found in eukaryotes.  Reversible attachment of SUMO is an essential protein modification in all eukaryotic cells, The family neither binds nor cleaves ubiquitin, but is a potent SUMO isopeptidase, and the invariant residues required for SUMO binding and cleavage, in UniProtKB:Q5W0Q7, are Cys-236, His-456 and Asp-472, all of which are fully conserved in the family. Member proteins are low-abundance proteins that colocalise with coilin in Cajal bodies. Peptidase_C98 depletion does not affect global sumoylation, but causes striking coilin mis-localisation and impairs cell proliferation, functions that are not dependent on the catalytic activity. Thus, Peptidase_C98 represents a third type of SUMO protease, with essential functions in Cajal body biology.	27.00	27.00	27.60	30.00	24.90	21.20	hmmbuild  -o /dev/null HMM SEED	275	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.99	0.70	-5.11	14	62	2012-10-10 12:56:15	2012-09-28 15:54:51	1	5	41	0	33	64	0	238.60	57	27.06	NEW	hCLQW+NspuLCWLDCILoALVHhEsLKcsl.sphssc.........pcSlht+Lhp+YsQAstLLpssppst.hp.s.t.s..............hhphss-lLscsEo.pLN-lRppIFtpLQPpL+CcL.GchESPVFAhPLLL+h-splEcLFhaSFSWpFECspCGapYQsRshKoLsTFTNllPEWHPLNAsHhuPCNsCpsKSQ+R+MVLE+lsslFMLHFVEGLP+NDLppYSFpFEGshYQlooVIQYpsp.cHFlTWlhsuDGo.WLECDDLKGP.hCp+Hp+hEVPASEIHIVIWE	.............h.slQW+Ns.uLCWLDClLoALVH.csL+psl.sthssp.........pcSlhhpLhpcYspAstLL.spphsthp.s.tp...............hhphssplhsch-s.pLsclRtplF.pLQPpL+C.pL..GchESPVFAhPLLL+h-shhEpLFhhSFoWpF-CspCGapYpsRphKoLsTFTNllP-WHPLNAsHhuPCNsCssKSQhR+MVLE+VSslFMLHFVEGLPpN.DLp..cYuFpFEGshYQlToVIQYpsp..pHFITWlLsuDGo.WLECDDLKGP.pscRHc+FEVPASEIHIVIWE...............	0	5	7	16
+15357	PF15500	Toxin_39		Putative RNase-like toxin	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and conserved cysteine, 	25.00	25.00	148.20	146.80	21.50	21.40	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.25	0.72	-3.86	3	3	2012-10-01 01:44:25	2012-10-01 02:44:25	1	2	2	0	3	3	0	100.30	33	10.51	NEW	tE+cssAc+KPADGGHDVVVTP-GVG+CSPPPCPVI+VEYKKELuAcP-LKpWNEoVQuhRKsDPchAAD.............EAAKLIpALEsARsNGG+APsEchV+	tE+cssAc+KPADGGHDVVVTP-GVG+CSPPPCPVI+VEYKKELuAcP-LKpWNEoVQuhRKsDPchAAD.............EAAKLIpALEsARsNGG+APsEchV+	0	1	1	3
+15358	PF15501	MDM1		Nuclear protein MDM1	Eberhardt RY, Coggill P, Hetherington K	re3	Jackhmmer:Q8TC05	Family	This family of proteins is present in the nucleus [1]. The function of MDM1 is not known.	27.00	27.00	27.30	27.30	23.30	26.60	hmmbuild  -o /dev/null HMM SEED	577	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.29	0.70	-13.10	0.70	-5.57	20	126	2012-10-01 08:54:23	2012-10-01 09:54:23	1	4	65	0	65	137	0	377.30	29	69.79	NEW	SEYpRsFpW+cshhscphsss.t...........pKssaAGL+S....Dph..GIs+EPshhuKRRVPhpcs.plscphcWptsss.p.ssss..csps..sspsppsppptshsptph..s.-ssphs.+spuhussSt.c...s............stpp.thssstts.spps.h..ssp...spphssths+hLpt+AGls.sh.tpphh+s.SEYQpQFsWKssp.ctuPhhsAp.pshtsps.t.hs..saps.sph.tcoEYpppFps.t.sc..p.cpphtt..............ppshcths.pp..pspKts-.hph.csctts.hstsp.c+p.p.h.hp..ph............t+hsoEY+u+FlSPupYhYccGuWs+s................................+pssssp.......st...lsshWYtEVpELREKActYRpRs.pGTHFSR-HLs.QlLocssslWDsSSsoSS-uslSsslpshcLus.............t.cp.p................................h.st...cpp.shccpspcssTtclshustsssPs+..R+LsWtpscss.pcctpppsptptp.........pppppttttpp.hpp.pc.c.pp..................psptsh.stuossuS.lS.........................uscsGRLPTPcL+...ph.sGspRoHaDhTTPAsG.GAVLlSPoKh+	...............................................................................SEYppsahW+p....pt..st.............t....su.h..................u.spEP.h.p+++sP.hs............t.p...........st........t..tt...................................................................................t........ptt.....s..........t..t.p......ss...........h..oEYp....pa...................hhsts..................sthptt.........................................t.hs..t.....p.tc...........php........t...p...t.....................tph..p.t.p.....p.t.a.hptttahh........................................................................lhELRc+At.Y+......pRs..Gschs.c.....lhpcppphW-.sSppSS.t.......slS.s.p...hts.........................................................................................................sh.....t...pcp..psst.pht.st..s.Ps+..c+Lh.s.tptt..p...pp.t.................tt...t.......p.t...........................st.p..tts.tss...t.........................sttstRhspPphh...th....pRh+ts.h.ss.t..t.hss........................................................................	0	20	23	44
+15359	PF15502	MPLKIP		M-phase-specific PLK1-interacting protein	Eberhardt RY, Coggill P,	re3	Jackhmmer:Q8TAP9	Family	\N	27.00	27.00	27.00	27.00	26.90	26.40	hmmbuild  -o /dev/null HMM SEED	151	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.74	0.71	-3.51	24	90	2012-10-01 09:08:51	2012-10-01 10:08:51	1	2	77	0	63	81	0	150.70	23	75.75	NEW	P.hs.......t.s....ssph..tt..........hu..tt.......t......s.P...p...........tP..........tt.......................shpptptht.sttp+pstpss...........ps.hG.......pt.t.pt....s.ppYa+PSMLEDPWtpLh.hp.sthspphsssptss	............................................................................................................s.tsssst......................t...t.........p....hG..tst.....s................ts.P...................tttPt.......p.stsPss.........................................................spppthu..hssu...tpppt.pss............sths.ssh.G....phpsRppphsp...........sl-pYa+.P.SMLEDPWtsLpshp.hths.p.ppp....ht.............	0	15	25	44
+15360	PF15503	PPP1R35_C	PPP1R35;	Protein phosphatase 1 regulatory subunit 35 C-terminus	Eberhardt RY, Coggill P,	re3	Jackhmmer:Q8TAP8	Family	This is the C-terminus of protein phosphatase 1 regulatory subunit 35. This protein interacts with and inhibits the serine/threonine-protein phosphatase PPP1CA [1].	27.00	27.00	30.40	29.50	26.00	24.90	hmmbuild  -o /dev/null HMM SEED	147	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.68	0.71	-4.68	21	62	2012-10-01 08:54:13	2012-10-01 10:52:41	1	1	54	0	42	66	0	138.20	29	58.61	NEW	PphpoolsLppELp.....httt.........chsut+ulpcpLppo...ps+stlp...spsscslNhspsppla+sLVslsVscppll...pptlpc+........pt.s..pchstspPsltpFhcs..p.hhhpssphtscths..phphpspPs.cshhshac+hp	...........................................................Pthpoolslt.Elp....thttt.........phsu.+slpcpLcpo...ps+sulp.....tplscsLNhstscplF+sLVsLpVs-ppll...sttlp-+.thh..t.ptss..pcsssstPchs.hhcs..pphhhpssphhhpsls..plphp.pPs.tshF.ha+ph......................................................	0	12	16	25
+15361	PF15504	DUF4647		Domain of unknown function (DUF4647)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAL5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 282 and 480 amino acids in length.	27.00	27.00	30.50	29.90	20.30	20.30	hmmbuild  -o /dev/null HMM SEED	457	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.92	0.70	-12.60	0.70	-5.63	13	45	2012-10-01 10:03:11	2012-10-01 11:03:11	1	2	27	0	21	50	0	351.10	52	88.73	NEW	MDLPDESQWDETTCsLAlCQHPQCWAolRRIERGHPRILuSsCKTPl-sEDKLPsLTlVNIoDSCFtA+R.lspppLstFTFTKs+SLLSpuSKFcSKFQG.Rs.KuLPDK-LIsposRsPKLSVLNLNETpLPsspDVRNMVVlWIP.......EEsEpp...........sSQsGKK+RKKSss.......Ks+s.lhhsG+Qpscoph..psPuhlVPPPSPV+hhEQLSoEulPhWsQhDhLPQDLLK-LLsscGKohPssEMKhQLAMMKKshPLEKsRPDSAISSKMFLSlHRLTLQRPuLRYPEHLKKLa.NLKoE...uh+KQQthQQpp.......VKTPsKKQEAKKKuKuDsGSQsTS+KpsusssaDPhh..spRTL.sppS-hK.QQpthpptGsshppsSTcRsph-hu-pshs.h.....ppcsPELschEsopKDlssphEslLEu.t.....sscsLSsShuphuWNPELKLLRILQATD-EDEE	.......................................................................................McLPDESQWDETTCshAVCQHPQCWAolRRIERGH......P.......RILuSssKT.Ph-sEDKLPsLTlVNIs..DSCFts++......LsthTFoKs+SLLS.tSKh.SKFpG.Rs.KsLsDKslhspspR.PKLsVLNLNETpLPsspDV+NMVVlWIP.......EE.Ehp...........spQptKc+RKp.sscp+..h.....hstpQ.s.t....tsPuhhVPPPoPVph.EQhss-.lPhWsQ.-hLPQDLLc-LLssttpoh.s.EhKh.pLAhMKKshPLE+sRPDSAIS...oKMFLolHRLTLpRPuLRYP-+LKKLa.NLKpE......uhpcppth....Q....p..pp.........sKTs.++QEsK+KuKu-st.Qsspccpssshhhs.hh..t.csL.tppsphc.pp..htp.u.t.ppsppcpsh.ph.ch...........hpssch..hEsspcDlss.h-hh.cs....ptp.shshot.hsphuWNsELKLLRILQsTD-E-EE....................................	0	3	3	4
+15362	PF15505	DUF4648		Domain of unknown function (DUF4648)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAG6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 115 and 207 amino acids in length.	29.00	29.00	95.90	95.60	28.60	28.50	hmmbuild  -o /dev/null HMM SEED	170	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.27	0.71	-11.27	0.71	-4.05	8	38	2012-10-01 10:06:50	2012-10-01 11:06:50	1	1	27	0	20	35	0	148.90	73	78.47	NEW	VVI-SDLY.spRPLELLPHRoDRhp..ssEuc..RhGRLQsupQ.Gs.sAKTsARPVGISEPKsopLCGNRAYGKSLlPPs....uRIoVKAPs..shEssAsGo-psAlLsRGSRHLKKMsEEaPsLPQGAEASLPLTGSuSCGsPSILRKMWh+HKKKSEYVGATNSAFEAD	...VVIESDLY.sppPLELLPHRuDRRD..sGDuR..RFGRLQsARPPssHPAKssARPVGISEPKoSNLCGNRAYGKSLIPPV....sRISVKsss..slEAsAhGoEpGAVLhRGSRHLKKMTEEYPsLPQGAEASLPLTGSASCGVPuILRKMWTRHKKKSEYVGATNSAFEAD...	0	1	1	3
+15363	PF15506	OCC1		OCC1 family	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAD7	Family	The human member of this family, overexpressed in colon carcinoma 1 protein (Swiss:Q8TAD7) has been shown to be overexpressed in several colon carcinomas [1].	27.00	27.00	44.80	44.60	25.30	24.90	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.68	0.72	-8.98	0.72	-4.09	3	14	2012-10-01 10:37:31	2012-10-01 11:37:31	1	1	11	0	8	20	0	57.00	77	93.44	NEW	MGCGNSTAuSAGsGpGPAGoAKDVsEESVoDDDKRRNYGGVYVGLPSDAsNMVSGQTKos+K	MGCGNSTATSAGAGpGPAGAAKDVTEESlTEDDKRRNYGGVYVGLPSEAVNMVSSQTKTVpK...	0	2	3	4
+15364	PF15507	DUF4649		Domain of unknown function (DUF4649)	Coggill P	pcc	Pfam-B_83 (release 26.0)	Family	This family of Firmicute sequences has members that are annotated as ribose-phosphate pyrophosphokinase; however there is no evidence for this attribution. Member proteins are all shorter than 100 residues in length.	27.00	27.00	27.00	28.10	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.88	0.72	-9.34	0.72	-4.21	14	556	2012-10-01 12:54:17	2012-10-01 13:54:17	1	1	311	0	28	149	0	67.10	50	97.61	NEW	IElTYLDAhKpERploFEsYpEF.pu.puC.lslsD.asVpKlsYpG+cLsYpGsYGDlahahhc.DLopYc	..............ElTYhDu.+sERTlpaEsaE-h.ho.puC.lslsDhh.VppLTa+G+plsYpGhhGDlahaL.+tDh..........	0	4	6	14
+15366	PF15508	NAAA-beta		beta subunit of N-acylethanolamine-hydrolyzing acid amidase	De Vivo M, Coggill P	pcc	Jackhmmer:Q13510	Family	NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, Pfam:PF02275.	27.00	27.00	27.00	27.20	26.90	26.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.10	0.72	-10.00	0.72	-3.64	85	283	2012-10-01 15:26:22	2012-10-01 16:26:22	1	8	132	0	173	266	14	88.30	28	24.28	NEW	sslP.ha.slsLDhPPpcRWpplhpsap..splpt.lhp.hlcpllss..hhst...hlhphlsphh.sthh..phl..sps....ascEl+GIAcss...ulsLG-llhhNlhYEl	........................s..sPhaslsLDhsP.cRWtplhppht..stlp...lhp.s.hpphlss.....hhPp...hl.hphlsphl.stlh.....pth...P..pP....ap...-El+GIAsss...slsLu-llhhNlhYEh.......	0	62	81	126
+15367	PF15509	DUF4650		Domain of unknown function (DUF4650)	Coggill P	pcc	Pfam-B_31507 (release 26.0)	Family	This family of vertebrate proteins lies to the C-terminus of Ubiquitin-specific peptidase-like protein family peptidase_C98, Pfam:PF15499. It might be acting as the exosite for the peptidase.	27.00	27.00	27.20	28.70	22.60	23.10	hmmbuild  -o /dev/null HMM SEED	520	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-12.00	0.70	-12.66	0.70	-5.58	16	46	2012-10-02 09:43:10	2012-10-02 10:43:10	1	3	31	0	24	45	0	485.10	45	49.01	NEW	plLSGscsLVDssllsLTLpEh........QVsSEuh..LEspPVt......EssslscssoLQsQ-...ShhuS.louPscEKlspsphlshSF.oQslssshpssQ.Nstsossstslss.spsss.LhQtlKslch............E......+ssphcphLsscsE...KLpscpsspSQsS.NLKc+pssA.pSpsssupSsQNp...shK-sQKKsFVGSWVKGLLS+GsSFMPsCVSApsRst.........lTDLpsoVKG..AsNFsGFKTKGl.pQ+up+sS+Ksp+ssspssssupssPt..tsssoustsp.ssssAsstlh++p-ssStssphs+sopssEsslSSus+s-usEuQlHKLRLKLLKKLKAKKKKLAuLhSSsps..............GphsS-shEplSps.......GSPNDCESl-DLLpELQaQIDlADsKSusTTssssS.hSuQoHEEILAELLSP.oTlsSoEhScssEsDhRYLEM..GDsphsuPs.PoEhsslspsshLpQDHNYCSPsK+sQsEVQsDSLsNsuCl+TLNLESPhKTDIFDEFFSTSALNSlANDsLDLPHFDEYLFE	.............................................lLSGscsLVDssIlsLTLEEs........plsSEuh..LEs+PVu......ENssllcssohpsQE...ShhuS.lSuPsc-KlhpsthlDhSFsSpslssshp.sQlNstsossspslss.spsos..LlQslKslch............E......+DsphcphLosKsE...pLcPcp.lsSQsS.NL++ppssA.pSQossucShQNp....shKEsQKKsFVGSWVKGLLS+GuSFMPsCVSApsRss............lTDLQsSVKG..AsNFGGFKTKGl.pQ+up+sS+Ksp+ssscPsshupsPst..usssssuhs..spspAsstshcKstssS..t.............suphsHsopsp.sulSSus+t-.sEuQlHKLRLKLLKKLKAKKKKLAuLhSSspp..............tsssS-slEplsps.......GSsNDCESl-DLLpELQYpIDhADscSusTosssso.hSoQoHEEILAELLSP..oTssSoEhScssEsDh+YLEM..GDsphssPs.PoEhsslspsspLpQDHNYCSPsK+s.pEVpsDSlhssuCl+TLNLESPhKTDIFD-FFSoSALNolAsDs.DLPHFDEhLFE............................	0	1	2	9
+15368	PF15510	CENP-W		Centromere kinetochore component W	Coggill P	pcc	Pfam-B_49340 (release 26.0)	Family	CENP-W is a family of vertebral kinetochore proteins that associates directly with CENP-T. CENP-W members are histone-fold proteins. The histone fold region is critical for binding to centromeric DNA. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.	25.00	25.00	38.10	38.10	24.80	24.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.47	0.72	-10.42	0.72	-4.02	6	38	2012-10-10 12:36:46	2012-10-02 12:47:25	1	1	26	0	16	43	0	87.60	64	99.88	NEW	MAlSTTVSQRK.IKRKAPRGFLKRVFKR+KPHLRLE+ssDLL...............VHLNCLLFV+RLAEESRTNACEsKCGVIKKDHVLAAAKVILKKSRG	..........................MA.oshVsp+K.IKRKAPRGFLKRlhK+pKP+LRLppsuDLL.......................VHLNCLLFlHRLAEEoRTNAsEsKCtlIKK-HVlAAAKVILKKSRG..	0	1	1	2
+15369	PF15511	CENP-T		Centromere kinetochore component CENP-T	Coggill P	pcc	Pfam-B_9162 (release 26.0)	Family	CENP-T is a family of vertebral kinetochore proteins that associates directly with CENP-W. The N-terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore.  Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure.  The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes.	30.00	30.00	30.80	30.70	29.90	29.50	hmmbuild  -o /dev/null HMM SEED	414	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.69	0.70	-12.63	0.70	-5.23	40	140	2012-10-10 12:36:46	2012-10-02 17:33:53	1	3	109	5	91	148	1	349.70	26	78.83	NEW	ssTP+uhtu...hphh.t+Rsuh.TPt..psRR+Sspt.............................p+-TPcslL+sLu+sLA.sSpslssSssps......................................ss..ppthp.scp-cs-sp.plptPRLSlPlst..............tcccp.............................-ssc.tPP+hShL.sts............Thp...SlEhsRRsho....p.tshhpchs......ussphSc.....h.s.spl.....ttspsh....sss.....hpssssppshsps.tstsphsppsss....................................................sh..tht........--.tphshths.ssssusstsphtpsps.....s-hptt.sstssstsp.s.t.s..tssssssstpsssptsss..........................stt..ph.hpssssssssspsstsh...sh.......................ppp+lS++.GlshPshPsssVK+lAppau+h.uthuKs+ls+-uLpAlppuo-hFFEQlu-DLpAYAcHA.GRKTI-EoD	.................................................................................................................................................................................................................................................TPht.tu......pRshh.Ts.......psRRhS.p............................pcpTshslL+plhhshs.po..h.pSs.......................................................t.cp.ptp....hPcLp.shs.................tcp.........................................ps....sschS.h.p...s...............ohp..p.thsR...Rs.s......tshhpchp.........ss...t.........ss.s.h......ttppsh...shh.....h.p.p..ps.sp...ptst.st..tsts..............................................................................................................................c-...hsh..th.ssts...s....tptt......tp.t.t..s..shts..p........t..ststtsstpsp..t.......................................................................................psssssttt..h.tst................................................htp+hs+......t...thshPphstssh.Kphhppas+..shhuKh.ls+cslthlpps.-haFcpls-DLpsaApHA.GRKTlc.pD....................	0	15	33	59
+15370	PF15512	CAF-1_p60_C		Chromatin assembly factor complex 1 subunit p60, C-terminal	Coggill P	pcc	Pfam-B_74766 (release 26.0)	Domain	CAF-1_p60_C is a family of vertebral proteins that is involved in chromatin assembly. CAF-1_p60 is one of the three subunits of the CAF-1 complex, and this domain binds to the C-terminal region of CAF-1_p150, family Pfam:PF12253. The N-terminal part of the CAF-1_p60 proteins is a WD-repeat structure, Pfam:PF00400.	27.00	27.00	29.40	28.50	19.10	20.80	hmmbuild  -o /dev/null HMM SEED	179	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.66	0.71	-11.32	0.71	-3.84	16	48	2012-10-03 13:48:41	2012-10-03 14:48:41	1	6	35	0	27	42	0	156.60	48	29.99	NEW	GIPLKEKPVLuV.RTP-TA.KKsK.uQsppsSSPGPR.sEGTPoSRspDPSSPssTPspu+.uPAssu.KDsPuossus+ushsssSEEK.s.QP.ouQNsKup.PRRVTLNTLQAWSK.TTP..RRINLhPLKTDoPssusPssls.SoPSoEclQ......s...EsPuDPpssPPE.KRPRLsEpptuspu.-	........GlPLKEKPVLsh.RT.Ps.TA.KKsK..uQopps.SSP.GPR.sEGTPsu.RspDPSSPssTPspup.uPAsss.h+DsPshssus+us.ss..sSEEK.s.QP.uuQNsKut.sRRVTLNTLQAWSK.TTP..RR.IsL....hPLKT-oPssusssss..osPusEphp......spsPsDs.spPPE.KRPRhpEp.tsspu............................	0	1	4	11
+15372	PF15513	DUF4651		Domain of unknown function (DUF4651)	Godzik A	adam	JCSG target SP18156A 	Family	family of short, secreted proteins specific to the Streptococcus genus, with distant homologs, not recognized by this HMM, found in other cocci. In all sequenced genomes, proteins from  this family appear in a conserved genomic context with an thioredoxin, tRNA synthase and tRNA binding protein, but the functional implication of this is unclear	22.00	22.00	22.10	61.00	21.10	18.40	hmmbuild  -o /dev/null HMM SEED	62	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.46	0.72	-8.81	0.72	-4.52	20	335	2012-10-09 15:12:14	2012-10-04 05:16:11	1	1	332	0	21	126	0	61.70	63	63.01	NEW	-+c+EclhpplRpaFSshGpIuVLYlssaESspcplsGGlVhEDGRpapFsYcpGplsYEEE	..M.KTQEELTpIVRDaFSDMGEIATLYVQVYESSLEoLVGGVIFEDGRHYTFVYENEDLVYEEE.	0	1	5	12
+15373	PF15514	ThaI		Restriction endonuclease ThaI	Eberhardt RY	re3	PDB:3ndh	Domain	This family of restriction endonucleases belongs to the PD-(D/E)XK superfamily. It cuts the recognition site CG^CG leaving blunt ends [1].	25.00	25.00	42.40	42.40	21.30	19.90	hmmbuild  -o /dev/null HMM SEED	202	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.59	0.71	-11.37	0.71	-5.03	2	3	2012-10-11 20:44:47	2012-10-04 10:36:20	1	1	3	2	2	4	1	154.70	49	96.47	NEW	LFpDc.IIsKlpp+LPYhFQLAELESSRAGKlGMpVGShREcIlSuLLIYKFGEpNVETslPITEPElDVKLFGs.ISIKTIoG+EPsGVKLIWTVDupKA+.FLETW+P+aDhILsHINWuS.GulYYIPs.VQpplFDplG+-KYIKLPKQGTNPRGVElSN-Ah+.lhss-cTMSIpIEWKKT.lpYssFKRWV-LWu-	...LFpDc.IIsKlpp+LPYhFQLAELESSRAGKlGMpVGShREcIlSuLLIYKFGEpNVETslPITEPElDVKLFGs.ISIKTIoG+EPsGVKLIWTVDupKA+.FLETW+P+aDhILsHINWuS.GulYYIPs.VQpplFDplG+-KYIKLPKQGTNPRGVEISN-AL+Ellsc--TMSIsIEWKKT.NlcYSPFKRWVELWu-.	0	1	2	2
+15374	PF15515	MvaI_BcnI		MvaI/BcnI restriction endonuclease family	Eberhardt RY	re3	PDB:2odh	Domain	This family of proteins includes the restriction endonucleases MvaI and BcnI. These enzymes both function as monomers. MvaI cleaves the sequence CC/WGG, where W is an A or a T nucleotide, leaving sticky ends. BcnI cleaves the sequence CC/SGG, where S is G or C, leaving sticky ends [1-2].	25.00	25.00	25.90	25.00	24.10	23.10	hmmbuild  -o /dev/null HMM SEED	220	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.66	0.70	-11.57	0.70	-4.33	21	77	2012-10-11 20:44:47	2012-10-04 10:53:55	1	2	72	13	23	80	38	220.60	24	68.37	NEW	llschcplpptGalp.....pRsusTGlGcTLEcLLGIpcNN.ctPDat.slELKopR.....p..ssohlTLFopsP....ss.h+usppl.hp+YGY.pcttp........tpLasTlpssphNsh...u...........hh.Lc.......l.c..pspp..l....p.lhhp.c.............phhs.hhshp......tpKppchhaV.Acoc.......hpsspEpF+atcu..hhhss..h..s..p..hhpLlEpGhItlDlcIsph.s..t.s..t.s+D+GsuFRIppcch.shLF	..........................hltpl+pltphsal...........stttss.s.u.l..........GpTLEshLGIttNs.ptPDht.s.hElKut+.....t..ssohhTLFs.pP............ss...pps...s.tth.hppaGa.pppt..........tplapoh..ps..sp.....ss.s...........hhlp.......................hs...ppcp..l....hthp.s..............................th.sh.ph.....................tpKhtpshaV.Acsc.............hpsspchFp.as.....ch...hhh..ps.....h....s..p..FlphlcpGhlhhDhchppt.t..h..t.h+c+GstFRIp.ppsl.thLa.........................................................................................................................................................................	0	5	13	19
+15375	PF15516	BpuSI_N		BpuSI N-terminal domain	Eberhardt RY	re3	PDB:3s1s	Domain	This is the N-terminal (nuclease) domain of the BpuSI restriction endonuclease [1].	27.00	27.00	57.30	247.20	20.40	19.80	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-10.78	0.71	-4.54	4	4	2012-10-11 20:44:47	2012-10-04 14:08:44	1	2	4	0	1	4	0	159.80	43	18.68	NEW	.sYsDDEVusFHPICcoALNpALpphGLDspYcVlH..HpslGol.sDFVlhpKsTcKalLhlEVKRp.utVpSTRY+hQApSYl.EAsp.plEpP....YYslTNLEVhshFKaDusRPsVspQllpPSPhcsGsFscshSEhaspLVcsFpslIshsVsDoGoa	..sYsDDEVusFHPICcoALNpALpphGLDspYcVlH..HpslGol.sDFVlhpKsTcKalLhlEVKRp.utVpSTRY+hQApSYl.EAsp.plEpP....YYslTNLEVhshFKaDusRPsVspQllpPSPhcsGsFscshSEhaspLVcsFpslIshsVsDoGoa.	0	1	1	1
+15376	PF15517	TBPIP_N		TBP-interacting protein N-terminus	Eberhardt RY	re3	PDB:2czr	Domain	This is the N-terminal restriction endonuclease-like domain found in several archaeal TATA-binding protein (TBP)-interacting proteins [1].	27.00	27.00	146.40	146.10	21.50	20.70	hmmbuild  -o /dev/null HMM SEED	99	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.13	0.72	-10.44	0.72	-4.35	9	13	2012-10-11 20:44:47	2012-10-04 14:39:59	1	1	13	1	11	16	0	99.50	55	43.95	NEW	YpELss+lKKVYu+VRhLDDYHWcIps-pIhGIHKKSsl+lcIclAcu+EcA-KLu.c.K.cssGIcIlVlPsKGTFYl+NGsFIhoh+aL+uTLtDIsDHI	YpELss+lKKVYu+VRhLDDYHWpIp--pIlGIHKKSslRlcIclA-u+EcA-KLAc.c.cssGIcIlVlPsKGTFYl+NGAFIhohKaLRuTLtDIsDHI	0	1	1	6
+15377	PF15518	L_protein_N		L protein N-terminus	Eberhardt RY	re3	PDB:2xi5	Domain	This endonuclease domain is found at the N-terminus of many bunyavirus L proteins [1].	25.00	25.00	25.30	25.20	24.20	24.60	hmmbuild  -o /dev/null HMM SEED	183	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.30	0.71	-11.04	0.71	-4.90	11	334	2012-10-11 20:44:47	2012-10-04 15:37:54	1	2	46	8	0	196	0	165.00	60	28.09	NEW	MDstchsQahsRIpss+DsplAKDIssDLLhsRHNYFGRELCpulsIEYRNDVPhhDIlL-hlPuhsshshcIPNlTPDNYllhsG+lhIIDYKVSVusESophThEKYsclhtclhspLslsaElsIIRhsPVspplHlsS-sFhptaPsIslslDFohFF-L+shLYcKFtDDEEFhhhVu	.................................Mp...ht.ah.RI.tsppsp.AKDI.sDLLhsRHsYFG+ELC+SLNI..EYRNDVPhlDIlLDlhP.............slD..P..hsl-sPaITPDNYLalNsh......LYIIDYKVSVSNESShITh-KYhElhcDIts.LulshEIVIIRIDPlScsLHIsS-cFKchaPslslDIsFspFF-L+phLa-KFtDDEcFL.hls.........................................	0	0	0	0
+15378	PF15519	RBM39linker		linker between RRM2 and RRM3 domains in RBM39 protein	Godzik A	adam	Jackhmmer:Q14498, residues 339-411	Domain	A conserved linker between the second and the third RRM domain in human RBM39 (CAPER) protein, also present in other RNA binding proteins, especially those involved in RNA splicing. This linker was implicated in interactions with ESR1 and ESR2. Preliminary results from JCSG suggest that this is a structured domain with a well defined fold.	22.60	22.60	22.70	22.60	21.70	22.20	hmmbuild  -o /dev/null HMM SEED	73	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.67	0.72	-3.69	26	417	2012-10-05 14:20:47	2012-10-04 21:53:55	1	17	220	3	225	369	2	75.20	32	17.17	NEW	LD..-sDsuGlshNshSRsALMpKLAR..o-p...ssss...sst.thht.t.th.......sh..s.........hASRCVlL+NMFDPuEEsspsW	.......................................-.-hsGlshss.t.uRhtL.Mt+LAc.......sss....hphss...............ssp..psh.th...sssh.................................s..s................................lAopChhLpNMFsPp...pEppss..............................	0	66	110	164
+15379	PF15520	Toxin_40		Putative toxin 40	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the type 2 secretion system [1].
	25.00	25.00	32.00	303.10	22.50	19.10	hmmbuild  -o /dev/null HMM SEED	178	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.33	0.71	-11.09	0.71	-4.83	2	4	2012-10-05 01:29:56	2012-10-05 02:29:56	1	2	4	0	0	3	0	177.20	72	11.02	NEW	RsPhoPhs.Thst.L.sA.AlAhcpA.Gphs.hphlG...GphAhDssspsshAhhs.GhthhputphlsNslPpphARVIPsth.hs.LGhPspSDVFlTAAcDItGLsshQIup+LTIPtSso.FplIcF.TP.sGlASPI.RssPGFlGtGRTLGGAREFsIPNt.IP.sAhhpIl	RSPMSPLGSTFNQ.LDVAQAIAYDKANGTMTSAEVIGNQWGDIAFDAVTTAVGAGVGRGTGLYKGQTLVTNSIPQKVARVIPDGIKTSMLGAPNQSDVFVTAAKDIKGLNAMQIANKLTIPQSSSGFKVIEFRTPMNGLASPINRTNPGFVGKGRTLGGAREFTIPNQQIPKDAIIKIV	0	0	0	0
+15380	PF15521	Toxin_41		Putative toxin 41	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin contains two structural domains, an N-terminal alpha/beta domain and a C-terminal all-beta domain. The domain contains conserved GxR, RxxxoH GxE and GxxH motifs and a conserved histidine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	48.30	46.40	16.60	15.80	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.03	0.70	-11.97	0.70	-5.24	12	19	2012-10-05 01:45:39	2012-10-05 02:45:39	1	2	16	0	7	21	0	254.30	26	28.37	NEW	phhtpppcutplLppVhhlLptG.lphhssptp.............tschphhstsVApsLuHGGRVsIplPshsstpt.........................................shhlsphL.Glspssh................p.sstVhpRhhuTHchplspN................tpFKEptu.....................................hsslpstl...................tpschaGhNlulGGlGppD......................asGDllLPD.GuHGHhalsa+sPosc+sGuL.lGlETsuPuthsshGahHsh+uoEt..ossPhusht.hKsDKlGsh.........thstRhVDLsphst......tDWpthlcchtppatstlt...ttpstppptthhpEhl	.............................................t.h.tpt.pthtlLpplhhlhp.G.h.hhptpt................hsphp.hp.slsphLuHGuRV.IplPshsstpt............................................l..hL.Ghp.tt...................tttV.pRhhuTHphphtps.................phcEptu.....................................hhsltstl....................t.chaGhNluhGGhGppc......................hsGcllhss.GtHGHhalhapsPssc+.GulhlGlETotP.......uthsshGhhHshpuopt..phsPtush...Kss+lGs..........phsshhVDLstht........chhthhcph.ptatttht....tp..ppth.....-...............	0	3	5	7
+15381	PF15522	Toxin_42		Putative toxin 42	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	163.70	163.70	303.20	302.10	25.20	16.80	hmmbuild  -o /dev/null HMM SEED	205	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.37	0.71	-5.13	2	2	2012-10-05 01:46:05	2012-10-05 02:46:05	1	1	2	0	2	2	0	201.00	29	8.90	NEW	PtlsAchpsL..AK.RltllGhtssssIa-pcch+hps..AF.++hR-hl-.........AlsusplssWppYspTs..Ss.......VGhHGQl.Gh.hG.hs.c.ssGpthG.......tsRtSHHhsQYLLlpYLpNh+us.p.hsH....+.hh.PshssoGspspuhou.sG+phD..Rl-.Gss.sDRGtshPAI.lAt+THQhGplHIsAt	PtlsAchpsL..AK.RltllGhtssssIa-pcch+hps..AF.++hR-hl-.........AlsusplssWppYspTs..Ss.......VGhHGQl.Gh.hG.hs.c.ssGpthG.......tsRtSHHhsQYLLlpYLpNh+us.p.hsH....+.hh.PshssoGspspuhou.sG+phD..Rl-.Gss.sDRGtshPAI.lAt+THQhGplHIsAt	0	1	2	2
+15382	PF15523	Toxin_44		Putative toxin 44	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved [DNE]xxH motif and arginine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, or Photorhabdus virulence cassette (PVC)-type secretion system [1].
	26.90	26.90	29.20	28.00	25.70	24.50	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.28	0.72	-10.06	0.72	-4.10	26	28	2012-10-05 02:16:07	2012-10-05 03:16:07	1	16	27	0	6	33	0	83.80	26	8.40	NEW	tssGsC..sstppscLpc-hs+h...Cp.pst..sCtss..sptplht+hcthppCtsuRpplspKCFsG.GDpGHppphspAapshspCpphl	.....t..sGsC..sstppscLps-hsch...Cp.pst..sCtss..sptplht+hcthppCtsuRpplspKCFuG.GDpuHppphspAapshssCpph..	0	2	4	5
+15383	PF15524	Toxin_45		Putative toxin 45	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly all-beta fold and a conserved ExD motif and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 7 or TcdB/TcaC-type secretion system [1].
	25.00	25.00	27.00	57.20	23.00	16.30	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.19	0.72	-10.28	0.72	-3.85	4	13	2012-10-05 02:17:50	2012-10-05 03:17:50	1	4	13	0	0	17	0	79.20	69	8.50	NEW	WolTuRIphAcLPspG+IRYIPP+sYpsStsLP+GPsNGYlDKFGNEWTKGP...SRT+GQpFEWDVQLScpG+cQhGhho+DGp.HLNlSlDGpITH	.WSITARIQYAKLPRQGRIRYIPPKNYSPSAPLPKGPNNGYlDKFGN.WTKGP...s.p+s.pFEWDVQLScpGhcphGhho+sGp.alNlu.DGpIoH.......	0	0	0	0
+15384	PF15525	DUF4652		Domain of unknown function (DUF4652)	Godzik A	adam	JCSG target SP18005A	Family	This family of uncharacterised proteins from Clostridia and Bacilli classes has an unusual structure of three beta propeller repeats that do not form a barrel, as in well known 6-, 7- etc beta propeller barrels, but instead are stacked in a three-layer beta-sheet sandwich. The function of all the proteins from this family is unknown.	22.60	22.60	23.70	22.60	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	200	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.54	0.71	-11.29	0.71	-4.88	7	33	2012-10-05 17:30:43	2012-10-05 06:04:42	1	1	33	0	5	28	0	166.80	35	75.33	NEW	NTspppspccs.ssstcpssscKpspcst...KspssssKphothpFlKKc..lscsocspFsTpWKsSpsspaSACIEGKGs-A.EEGlGKIaIKs.pspphathpIppsp.K.oPKYIEWhDDcNLhVlIupuaGTVSpGGsLYhlNlpTGpso.lhpspD+KpQllSApKpGDp.....lsLpl.VY-DDsh.cSHhEshTIssh	............................................................................................................EuIGclYlKppsssch.hhLpIsp............pp...........phoPK.alhWlDDcNLhVIIGpuaGTVSKGGNLYplNlpssphs.lYcsp-p.KppVlSscpst-p.....L.LplslY-sDsh.csH.EphsIt..t.....................................	0	2	5	5
+15385	PF15526	Toxin_46		Putative toxin 46	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	An RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, with two conserved lysine residues and and [DS]xDxxxH, RxG[ST] and RxxD motifs. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 4, type 5 or type 7 secretion system [1]. This is also referred to as the E. cloacae CdiAC and has been shown to target tRNAs.
	25.00	25.00	32.80	32.50	20.50	19.30	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.82	0.72	-9.57	0.72	-3.82	12	100	2012-10-05 10:45:44	2012-10-05 11:45:44	1	7	98	0	10	56	0	71.80	61	27.41	NEW	AppAAKcLGY.pcsp......hSHGphlFhppKs.....shYIo.DhDu......Hs.GGsWKtAso.+sL........spKpsR.GTYDtsLpRIGD	..........A.htAAKKLGY.pthKc.....sppGttlFKKspp.......YIShDhDu......Hp.GGAWKtASS.KNL........spKcTRsGTYDtNLp.RIGD....	0	2	3	6
+15386	PF15527	Toxin_47		Putative toxin 47	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly beta fold and two conserved histidines, two aspartates and a glutamate residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 5 secretion system [1].
	25.00	25.00	218.70	218.70	24.20	19.10	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.66	0.71	-4.36	4	4	2012-10-05 10:46:14	2012-10-05 11:46:14	1	4	3	0	3	4	0	128.80	57	4.74	NEW	ltPDYATlssGlLSuuuSulVNLYDGTpYlAGGVuQosPSuVSapPGlouTlGWIaGApsApusNSFLNGDGNQAFVSIPTPashNVlGAVTHAYGGuTAIElGlGpPGsloaGlsPWSHosPVsssuK	ltPDYATlssGlLSuuuSulVNLYDGTpYlAGGVuQosPSuVSapPGlouTlGWIaGApsApusNSFLNGDGNQAFVSIPTPashNVlGAVTHAYGGuTAIElGlGpPGsloaGlsPWSHosPVsssuK.	1	0	0	3
+15387	PF15528	Toxin_48		Putative toxin 48	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system [1].
	26.20	26.20	26.80	47.80	23.00	25.50	hmmbuild  -o /dev/null HMM SEED	189	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.21	0.71	-11.41	0.71	-4.41	9	16	2012-10-05 10:46:39	2012-10-05 11:46:39	1	5	13	0	6	13	1	172.10	31	18.04	NEW	lshGhNhshsaps.G......sFphusGlGlts....sh.GaGcsu..httuathua.....t.sphuYs.sshh.ph.stQpoGslshth.scaplhhEND........hh.Gs.s+D+aRTuAlplsls.....phohGhtlaTGcstcps.hcs.s.shst...................shhshppp.hGshppG...ppY.phushalGhps.....hRlGhsu-p.lRphhQN.lhHc	........................................................shGhshthsaps.G......sathssGhslhs.....h.G.stps..hhhuhhhsa.....t.hphuah.th.h.ph.ttQpoGhltht..scaphhhEND........hh.Gs.spD+aRTuAlplsht.....phshGh.laTGct.p..ps..ct.p...st...................GhhstphphGhshphG.........cpY.RhushalGhss...........aRIGhDu-p.VRchlQNhhhHp.	0	3	6	6
+15388	PF15529	Toxin_49		Putative toxin 49	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved ND and DxxR motifs and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or TcdB/TcaC secretion system. Interestingly, the toxin is also found in type-II toxin-antitoxin systems [1].
	38.30	38.30	51.40	51.40	25.30	24.40	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.58	0.72	-10.16	0.72	-4.05	15	25	2012-10-05 10:47:04	2012-10-05 11:47:04	1	8	24	0	6	28	1	88.70	40	7.83	NEW	tpuRstssushPputGpsc.sl.hc.cs..G..plspYsTYsscGh......l.KcaRss..G+sHGslssPpVhE.tppNpsPcushhh..sptc..sRtspPcElP	....h.puRs+ssGP.PcApGssH.Th.a+t+s..G..+lTpYuTYspsGs.....hhKQaRGp..GKPHGsVPRPNVKp.sphNpsPtsppth..PKp+..VRpPh.cEhP...	0	1	5	6
+15389	PF15530	Toxin_50		Putative toxin 50	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a mostly all-beta fold and conserved FGPY motif and a histidine residue. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 5 secretion system [1].
	25.00	25.00	143.30	142.70	22.30	20.60	hmmbuild  -o /dev/null HMM SEED	168	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.20	0.71	-10.81	0.71	-4.34	5	24	2012-10-05 10:48:05	2012-10-05 11:48:05	1	9	20	0	2	21	0	155.40	71	9.16	NEW	sPPRVQQDsSLAhDhuQcGhsptEIscAlDtSHlGPSWGTEYKV+ssVKupVuuGhusGYpl-GoIDsc+lSVNsG-ThulGA+AGASIGLoFGPYFPGllsss-RDYShulGhGVhSVulSsGKDGlGFSFGVGPSWGaSuopo.stscpVDlNGooToElY+YDFK	SWNQYAQDNNLTPEQVQEGMNRIAIGE.......GPSWGTTYKVHPVVQAGGDVSFIRGYTLSGTIDDNHISVNQGDIYSIGAHGGASIGLSFGPYFPGLINSNDNDYSINGGFGVGAVGLSTGKDGVSFTFGFGPSWGWSATEI....KGVDVNGTSTSEVYRYDFK.....	0	0	0	2
+15390	PF15531	Toxin_51		Putative toxin 51	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and conserved aspartate and glutamate residues, and an RxW motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system [1].
	25.00	25.00	27.70	27.70	22.60	21.90	hmmbuild  -o /dev/null HMM SEED	128	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.93	0.71	-10.63	0.71	-4.34	6	8	2012-10-05 10:48:58	2012-10-05 11:48:58	1	5	6	0	5	10	0	125.20	25	7.22	NEW	hGlNspu-sL...sus.Gu..cTasspsYuts.stuhsls-...tPlWpssVcsAltNPsV+IuloLDGh.su..........pshsEAhpsshp+Gcuht.scWc...ttGhGTAWEMscltpAlRhts..............RsW-SIcWYhssccs	...............hGhNshs-tL...sus.Gt..coasshsYups.shshsssp..stshWhssVcsAltNPsV+lpVsLDGhssu..........psh.-AFhsshppGtsh..tsa....ttGtGTsWEMuplupAlRht-..............RsW-SIcaYhsscp......	0	2	2	5
+15391	PF15532	Toxin_53		Putative toxin 53	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and two conserved histidines present in an RxH and THIP motif. The domain additionally has a highly conserved arginine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6 or type 7 secretion system [1].
	25.00	25.00	49.00	46.50	24.30	23.10	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.53	0.72	-10.35	0.72	-3.81	11	20	2012-10-05 10:50:16	2012-10-05 11:50:16	1	6	20	0	5	21	1	103.50	39	15.15	NEW	scPhshlscssppps..h......psss..pshchKWt......ss..shsaclRlHssDsssstGsNuusG.IaRlp.............hGhcY.hDssGpaa+putlp......hp...sPpasppAuNcTHIPl.	..................................u.sPtchls.sh+ppG..Lp....scshP...thKtKas......su..shpYcVRsHsssPoAPsGSNuusGsIYRIut........tpQGhGhEY.hssDGsWaHpSsL+......spSPsYNssAANDTHIPls.	0	5	5	5
+15392	PF15533	Toxin_54		Putative toxin 54	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and [DN]xHxxK and DxxxD motifs. It is usually exported by the Type 2 secretory system [1].
	26.30	26.30	26.30	30.30	26.10	23.90	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.51	0.72	-9.20	0.72	-3.72	8	17	2012-10-05 10:51:18	2012-10-05 11:51:18	1	2	17	0	3	16	0	62.90	47	25.94	NEW	NstQDKhLohuDIc+LKcuGhDhH-LK....Gt+.NuS+hDLYKD+c.GNIYlKPKGGpGtG-PTGlNIN	...hptsK.lshs-.chLKcsGlDhH-LK....Gtp.ssSKhDlYhDcp.Gplalh.KGGpGts.sTs..Ip..	0	2	2	3
+15393	PF15534	Toxin_56		Putative toxin 56	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a conserved histidine residue and a KH motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 secretion system [1].
	25.00	25.00	29.90	29.70	24.40	24.40	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.05	0.72	-9.55	0.72	-3.49	14	39	2012-10-05 10:52:08	2012-10-05 11:52:08	1	4	37	0	3	32	0	76.20	35	26.79	NEW	hssNKh.pHIhssKHsWsplhct...sapplpslhppsh+pGppsshppushpc.....shphsGpslsVThth.hcGphcI.SsuWVp	...psNKh.pHIht....sKHsWsplhKt...sappVpslhp+sM+pGpposYppS...uhp+.....shphsscsVslThsh.pcGpl+I.SsuWVp....	0	1	2	3
+15394	PF15535	Toxin_57		Putative toxin 57	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and a conserved glutamate residue, and [KR] and Hx[DH] motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system [1].
	25.00	25.00	32.00	32.00	24.70	23.10	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.33	0.72	-9.81	0.72	-3.93	15	22	2012-10-05 10:52:50	2012-10-05 11:52:50	1	5	21	0	8	21	1	79.00	29	16.33	NEW	ucssus.sspEhht....hssccGhp.ass.sPs...tsG+.uuWhcscsGcsahPssptssst....ptGPHWDVpcPpGt.....apsshPpsh	.................ucs.ss.sspEhh.....hssccG.p....ats.sPs...hsG+.suWhssc.Gpsah.shttsstt....ptGPHWDVpcsput.....acsshPtt.....	0	3	7	7
+15395	PF15536	Toxin_58		Putative toxin 58	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-beta fold and conserved aspartate, arginine, histidine and cysteine residues that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	32.60	160.10	24.70	18.40	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.72	0.71	-4.30	3	5	2012-10-05 10:53:14	2012-10-05 11:53:14	1	2	2	0	4	5	0	128.40	56	13.54	NEW	RAGIuVPsAthRYERQEPsAcLQtRARIlASPDVRVAV.PGTRITYsLs+su-.LHApuu.YpYQWYhLNDP+TopTaG+P..ARV-Gu-GP+u-FRAGFVGNHKIICK.Vh..AuGDuQAPVFYEaPQsVVSEGK	RAGIAVPDAALRYERQDPAAELQGRARIVASPDVRVAV.PGTcIoYALAHGoQuLHASSSPYRYQWYhLRDP+ToRsHGEP..ARIDGPDAP+A-FRAcFVGNHKVICK.VTPRAGGcAGVPAFYEFPQTVVPEGK.	0	4	4	4
+15396	PF15537	Toxin_59		Putative toxin 59	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2 or TcdB/TcaC-type secretion system [1]. A  of this, the Pseudomonas RhsT-C has been experimentally characterized.
	25.00	25.00	45.80	72.00	20.00	17.50	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.26	0.71	-10.61	0.71	-4.04	4	7	2012-10-05 10:54:46	2012-10-05 11:54:46	1	6	7	0	1	9	0	117.90	37	7.14	NEW	GohhutsshpcGulssppush+.GSGPssGhlEVS-uhpSoKul+Nats...uGs.-FVFDPppppFshGsst......hpsHptlA+uhG...As-usllGGRh.R.psGplhTsEaSGHYGcpW..osEhRpQ	.......t.ht.hhhhpGuls..sp.shhp.GSGPssGhltVS-pspSstAl+NatP...pGs.-FVFDPppspFssGssp......htsHptLAculG...AscusllGGRhhRsssGpl.TsEaSGHYGppW..ssphRp............	0	1	1	1
+15397	PF15538	Toxin_61		Putative toxin 61	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin domain found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold with a conserved glutamine residue and a [KR]STxxPxxDxx[ST] motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1].
	25.00	25.00	27.70	27.10	22.80	19.70	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.22	0.71	-11.07	0.71	-4.23	8	33	2012-10-05 10:57:02	2012-10-05 11:57:02	1	3	32	0	5	32	0	150.90	47	35.76	NEW	RRsYLNcKFGRTGDLs+DINIRGN+EsAssFaKSpGhspsc.hEsYMsGIDFocPVpVETIN+GKpLaQaQsPGuhQ.GsWYSLossVtPTcLGINPpGplauT-hlVPKVhssYQSpcKVplLRSTAAPsLDTWSV.cpPYpAcGGApQhhSspK-lF	..................................RRtYLNpKFGRoGsls+DIshRuN+EhAscFF+Sc..sls.tc.hcsYMpGlDFs+PVpVETlssGKpLWQaQsPG..u..hQ.GNWYoLoPsVpPT-LGINPhGphhtssh....hhsKVLNsYpoTpKVpVLRSTAAPslDpWS....V..tpsYsAcGGApQlhSsp+t.F.................	0	3	3	4
+15398	PF15539	CAF1-p150_C2		CAF1 complex subunit p150, region binding to CAF1-p60 at C-term	Coggill P	pcc	manual	Domain	CAF1-p150_C2 is part of the binding region of the CAF1 complex p150 subunit to the p60 subunit. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork [1,2].	27.00	21.60	28.10	21.60	26.30	18.60	hmmbuild  -o /dev/null HMM SEED	292	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-12.01	0.70	-5.29	4	69	2012-10-05 10:57:55	2012-10-05 11:57:55	1	8	48	0	39	64	0	238.00	41	28.17	NEW	AKEWDEFLAKGKRFRVLQPVKIGCVWAAD.RDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPlSLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDCMIVDVPDAsEVQAPCGAASGAGGGVGVDTGKATLTASPLGAS	....................................................................AKEWD.EhhuKGK+h+VLQPVhlGClW..tut...ts.s.....ss-LclLQpFs.ACh......L-s..s.......spE.-.p......s.P.c.s...o.p+p....p.+..DpQlLsQLLPLLHGNVNuSKhIIpEFQEh.C...Rp.....Gh..h..u..p.t..ss.......S..s................Pup.......oh...p..oPt.sps.sslPSKu+LKR...lISENSV..Y.E.KRPca..R.h.CWYVHsp.VLc..pF..pQ-cLP.VPCQWsYlTp........s........Ps.ss...+.-.D.sG.s.....s..ss.ss.s.p.usP....h....ShKRKssuSMsITpFMK+.tt.t.h.....-.DGFQuD............-Chhht.........................................................................................	0	8	10	20
+15399	PF15540	Toxin_62		Putative toxin 62	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a two conserved aspartates, a glutamate, a histidine and an arginine residue and an RT motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6 or type 7 secretion system [1].
	26.60	26.60	27.20	84.40	26.00	24.40	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.66	0.71	-10.42	0.71	-3.97	6	18	2012-10-05 10:58:54	2012-10-05 11:58:54	1	6	18	0	5	18	0	113.50	57	17.75	NEW	stspaphNsspDlDhRGpGpoY+-....ALDEAF+RTGlPKcpFsVTK...WuKDcsGKShPVEa...pGPN.GApVNlDlP+hs.....sshssGPcpPHlGYQTsGK.uGuutsRGHIhlDslPssR	.N.LYpYAPNPIRWIDPLGLAILEHQ....SNFDAARRTGFENAGMTNPEDVTFSKVDPKTGTVVEF...KGPN.GAKVAYDAPHAD.....MDVTAGHDKPHVGWQSAGKRGSGGANRGNITYDGPQHPH........	0	1	1	4
+15400	PF15541	Toxin_63		Putative toxin 63	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	140.00	139.00	23.40	18.60	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.51	0.72	-10.37	0.72	-4.07	4	4	2012-10-05 10:59:14	2012-10-05 11:59:14	1	2	4	0	2	4	0	97.80	47	14.68	NEW	LKGWERAH..GsGhGsEAKtGIhYAP.tVNQElQNRGhEKaIRELa.lspssslKlFhpscshAaP..........GpLhLcolpYcV.tEttstRRIl..F-ASl	LKGWERAH..GsGhGsEAKtGIhYAP.tVNQElQNRGhEKaIRELa.lspssslKlFhpscshAaP..........GpLhLcolpYcV.tEttstRRIl..F-ASl	0	1	2	2
+15401	PF15542	Toxin_64		Putative toxin 64	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems that is proposed to adopt the BECR (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains two conserved histidine, a serine, two lysine, and a threonine residue and a HxVP motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7, and MuF-type secretion system [1].
	26.90	26.90	26.90	28.10	24.00	26.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.48	0.72	-3.45	34	374	2012-10-05 11:00:33	2012-10-05 12:00:33	1	12	254	0	20	174	0	87.00	40	46.17	NEW	psp+Qs+HhhGpp.Ycpph....hsstth.Sahh.lsscclpcLlpphuusGpllhs.ptG.appKElIDF.sphIGcsa....hsGca.l.cTshGplHYSK.sG.sHIVPth	......................tQt+H..spp.Y.ppK.....sst.hh....SYhh..ls.pphpclhcc.hhsGsllhs..ccs.FchKplIsa..pplIGKsa.....hsspY.l.ETphGKlHYSK.TG.sHIVPal..	0	6	9	18
+15402	PF15543	Toxin_65		Putative toxin 65	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	206.90	206.10	21.90	21.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.75	0.71	-4.52	2	2	2012-10-05 11:01:05	2012-10-05 12:01:05	1	2	2	0	2	2	0	130.50	37	12.91	NEW	MRRR.ht.hASs.-p.LsFLLstcGpa.......RStRsh+t+.hhpcPD..IVQhGHhhSs....thucc-alMLpsu..N.hsshT....chpGuVhspsAV.ItGhsVDl.TAphWEshGhL.tGTVusuPhVp.P	MRRR.ht.hASs.-p.LsFLLstcGpa.......RStRsh+t+.hhpcPD..IVQhGHhhSs....thucc-alMLpsu..N.hsshT....chpGuVhspsAV.ItGhsVDl.TAphWEshGhL.tGTVusuPhVp.P	0	0	1	2
+15403	PF15544	Toxin_66		Putative toxin 66	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold that is usually exported by the Photorhabdus virulence cassette (PVC)-type export system [1].
	25.00	25.00	486.60	485.90	17.50	16.00	hmmbuild  -o /dev/null HMM SEED	273	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.01	0.70	-11.59	0.70	-5.13	2	2	2012-10-05 11:01:34	2012-10-05 12:01:34	1	2	2	0	1	2	0	269.50	35	70.37	NEW	hsTulsPph............ulhupspstsppspuhGQslhA.sEl+LhDERshhssLsGR..NLGu-GTYhINPpISATLGts.uch.usPplFhG-polGuHV+LMVpNPQT.pch.sGGapth+FoApYpLKNucoWpTPNMshNhtstNpRtLcGSlsAsusL.Itt.lsVpusApIGss.ooEpshcAsl-EFpLGGosoYasHhHclphhlsSuG.Asup.h-SsGcG.pTscsVaspphstucph-spcGS+sh.p.tphP.RVpMPL.+	hsTulsPph............ulhupspstsppspuhGQslhA.sEl+LhDERshhssLsGR..NLGu-GTYhINPpISATLGts.uch.usPplFhG-polGuHV+LMVpNPQT.pch.sGGapth+FoApYpLKNucoWpTPNMshNhtstNpRtLcGSlsAsusL.Itt.lsVpusApIGss.ooEpshcAsl-EFpLGGosoYasHhHclphhlsSuG.Asup.h-SsGcG.pTscsVaspphstucph-spcGS+sh.p.tphP.RVpMPL.+	0	1	1	1
+15404	PF15545	Toxin_67		Putative toxin 67	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an alpha+beta fold and HxR and HxxxH motifs that is usually exported by the type 2 and type 6 secretion system [1].
	25.00	25.00	44.10	43.20	24.30	23.80	hmmbuild  -o /dev/null HMM SEED	70	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.86	0.72	-9.36	0.72	-4.10	7	8	2012-10-05 11:02:03	2012-10-05 12:02:03	1	4	8	0	4	8	0	69.90	47	10.05	NEW	LAsD.KQsphlRGWl+pElp+lcp....sp..........+pslRlP........PGh-LAHhRGhEupKGYuYpYosLQstcLHKhQH+hD	LAsD.KQsphlRGWl+pElp+lcp....sp..........+pslRlP........PGh-LAHtRGaEupKGYuYpYSsLQstDLHKhQH+hD.	0	2	3	3
+15405	PF15546	DUF4653		Domain of unknown function (DUF4653)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8TAB5	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 229 amino acids in length.	27.00	27.00	90.20	81.70	23.40	22.70	hmmbuild  -o /dev/null HMM SEED	240	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.63	0.70	-11.78	0.70	-5.08	6	45	2012-10-05 12:37:08	2012-10-05 13:37:08	1	2	32	0	24	42	0	196.70	64	97.68	NEW	MF.AlQPGhs......ctupaLGu.PsuVsp.EhpPDSNSNFVppuhDANENWpth.utl-shh.+SpSE............ScNpshtu.t...........P.......EutVRSPPEGAEIs...GscPEKsscsssss...SPLEDNGYASSSLSlDS.sSSP-susuosp......uP.u.P................sDsLhPoVupAhQQLQApERYKEQEKEKHHVHLVMYRRLALLQWIRuLQppLsDQQsRLQESFDTILDNRKELIRsLQpttsPotsQ-pu	..............................................................................................................................................MF.hhpPshs......ctup.lGs.Psulsp.EhpPDsN.NFhtp.shDsNENWpth.uts-shh.pSpsE............psNpshts.t..................sEttVR..SPPEGAEls...GscP..Ec.sssussp...SPLEDN..GYASSSLSIDS.uSSP-suCuTPp.......sP.u.P.........................sDsLhPoVApAVQpLQspERYKEQEKEKHHVHLVMYRRLALLQWIRGLQppLlDQQsRLQESFDTILDNRKELIRCLQQttsPstspptu...........	0	1	3	9
+15406	PF15547	DUF4654		Domain of unknown function (DUF4654)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NEQ6	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 169 amino acids in length. There is a conserved IDC sequence motif.	27.00	27.00	28.00	71.60	21.10	18.90	hmmbuild  -o /dev/null HMM SEED	138	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.43	0.71	-10.87	0.71	-3.85	12	24	2012-10-05 12:39:56	2012-10-05 13:39:56	1	1	21	0	14	21	0	132.00	62	78.91	NEW	AppQKAlPsAHLTFlIDCupGKQLSLAAPssPPpuP....pPp.GPVsPPMKTYIlFCGcsp.P.hTQcssLGtssLApA+sTLPPpRGhsAPsS.PsSshsPQEsPcAKGsPlKssss.RSSsWGTVKGSLKALSSCVCGQA-	..At+QKAlPsAHLTFVIDCspGKQLSLAAssuPPpAP....uPspGsVTPPMKTYIlFCG-N..PpLTp.sPhGGGsLAQARuTLPPCRGssAsAS.PlSPhsPQEsPEAKGpPlKssPs.RSSsWGTVKsSLKALSSCVCGQAD..	0	1	1	1
+15407	PF15548	DUF4655		Domain of unknown function (DUF4655)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NEP4	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 533 and 570 amino acids in length.	27.00	27.00	439.50	198.90	24.50	21.00	hmmbuild  -o /dev/null HMM SEED	532	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.90	0.70	-13.08	0.70	-5.60	13	28	2012-10-05 12:43:12	2012-10-05 13:43:12	1	3	21	0	15	27	0	485.20	57	91.37	NEW	lKTNKsGSKVAVSAp+GuEV.ossoPQRGpGY.lhASSQRSAAlSlSPsspR..RSEAApsTo.+SsSDaPRosSPQoGPulSussoP.RGTE......TRoRsEs.............RpsSPpRKsQQsQ..TssSHsluh....pRNVSPsREEuTRRGuEsKsGR.ElopRsSlssDAKSSRRLSFlDpKDNlp.......s.l..E-DPPSKVQsPQGVRVPRRh.laPKDEAVQT......EPIR+.hTsuElRSP+sPsoPE+uSSRhssD.RsspR+lPuQEuEhGPpSSIhoEPKAL+RN..hsLESSLKLSVLKDLDuGHRV.ShRs-PESh+KpSVYsETKPSsKVLIuS-VEosh+SShRuDsEluRRVTISsGsQSlpsspRsTuRssSESP.+KSolasoP-..aKt....p..+Pscsshh.stss.RYs......Es.SpKPSlHA..ELELTPRPLPPRSLPRYGPDSSWWALLNPElEhP.QSpPTT.........PD.....FEPK...SPP.....PLDPhlShaEMDSSPFCEDLhFQREKA........ossP....PssPKESPSpA.PLREVPQ...uP..........KaTsKQPlQRFSAFFLDVSEEMYNRVIWWL	..VKTNKsGuKVAVSApRGuEV.TsToPQRGpGY.llASSpRSAAlSlsPS.pR..RSEAAHsTo.+SuSDYPRSsSsQsGPGh.ussoP.RGoE......TtsRoEu............uRHsSPHpKoQQ.............oQ..ThASHssoh....pRNVSPsREEusRRGGESKsGR.-lup+sS.hPDAKSoRRLSF.DQKsNLp.......o.l.hE-DPPSKVQNPQGVRVPRRhLsaPKDEAVQT......EPIp+hhTsuElRSP+sPo.PEHuSSplusD.pTAQRRlPspEuEsuPhuSI.oEPKALaRN..hNL-SSLKLSVLKD.DGsHRV.Ss+s-PESl++aSVYsETKPSsKVLlSSpVESNVRosIRGsoEVGRRVTISPusQSlpssp+VTupuVSEus.+KSShaVTPEshYKQ....pTp+PscsshMS.GPs.RYP......E..SpKPSlHA..ELELTPRPLPPRSLPRYGPDSSWWsLLNPElEhP.QSpPTT.........PD.....FEPK...ssP.....sLDshLShachDSSPFCEDLhFQREKAS.SP............PssPKEsPShA.PLpEVPQ...sP..........KaTsKQPIQRFSAFFLDVSEEMYNRVIWWL..	0	1	1	2
+15408	PF15549	PGC7_Stella	DPPA3;	PGC7/Stella/Dppa3 domain 	Iyer LM, Aravind L, Eberhardt RY, Coggill P	re3	Manual	Family	The domain belongs to a fast evolving family known only from the placental mammals [1-3]. The PGC7/Stella/Dppa3 protein protects imprinted regions from demethylation post-fertilization [3]. This suggests that it might bind methylated DNA sequences directly [4]. The conserved core includes a postively charged helical segment and a C-terminal CXCXXC motif that is predicted to chelate a metal ion [4]. Most placental mammals contain 3-6 paralogs of this domain family. The CXCXXC motif is also conserved in a subset of fungal MBD4-like proteins [4].	32.30	32.30	32.30	36.00	22.70	27.80	hmmbuild  -o /dev/null HMM SEED	161	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.13	0.71	-11.22	0.71	-4.25	11	48	2012-10-08 22:59:17	2012-10-05 13:55:24	1	1	21	0	18	71	0	155.40	37	88.99	NEW	MD.P.QKhNPshss-S.....S.htstEsSp-ssus..SQPshSEpLhhsLusLosuPGsc.s.sPLPEuLLpQ+YR--..KThpERphERlt....asQRK+phLtplRR++hcHhAPY.....plcc....cu...+lssu.sD..RcQNtFRCcC+YCQSpR.NhsG.Pu-pp......SW-sLspGLouLslSlGTNpss	.....................MD.P.QKhNPs..scS.....S.MsstEsSp-ssusSQP.hSEpLhhsLSsLo...sPusp.s.sP..LsEuLLppphRpc.....cohpE+hhE+lt....F.pR+hthLtpVcRc+hs+Mtsa......tlt+...........ct...+hs.h...s-..+spp...FRCpCpYCpupt.........................W-......su.shplGsspss...................	0	2	2	3
+15409	PF15550	Draxin		Draxin	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NBI3	Family	This family of proteins inhibit Wnt signaling and act as chemorepulsive axon guidance molecules [1-2].	27.00	27.00	33.60	33.60	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	324	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.13	0.70	-12.44	0.70	-4.77	10	51	2012-10-05 13:15:45	2012-10-05 14:15:45	1	2	36	0	31	52	0	272.10	61	88.17	NEW	tpshssNshppppPththspusHp...........+RpGhuKKcRusGhhu..t.thssscsss-uoslpuLssVtLEt.tP...uuLhp..cK-sahGhchP.stR-Np.sG.pc..+s+K+uR-H++..........sRRD+lRpp+Gc...stP..SSlh...Kcscs.EDth.ss..............s-ssosluPslh.hoshtss.shoEcsssLPssSs+PQh..u.Rs+ssGDVMPTLDMALFDWTDYEDhKP.-hWPSuKK..KEK+RSKshSsGNpTosA-s.EPCDHHLDCLPGSCCDLRcHlCKPHNRGLNNKCaDDCMCpEGLRCYAKFHRpRRVTRRKGRCV-PEolNuDQGoFIsV	......sps.PEN+lsh.tPtLapspuuHH...........+R+G.uKKcpusGhsu..t.ptssspss+puotLstht..h.tp.uP...AuLhQ..cK-lhLGhthPasE+ENpsPG..E...+s+K+uREH+R...........RRDRL+hHRG+shstuP..SSLh...KKsEhsEsth.su............shpEuSTSLAPThhaLToh-su.suTEEs.lLPsTShpPQt....psRsDGEVMPTLDMALFDWTDYEDLKP.-sWPSAKK..KEK++uK..sSsGNETSsAEG.EPCDHH.DCLPGoCCDLREHlCpPHNRGLNNKCFDDCMChEGLRCYAKFHRNR.RVTRRKGRCVEPEoANGDQGSFINV..............	0	2	5	12
+15410	PF15551	DUF4656		Domain of unknown function (DUF4656)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NAX2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 286 and 398 amino acids in length.	27.00	27.00	37.50	37.50	18.40	18.30	hmmbuild  -o /dev/null HMM SEED	370	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.15	0.70	-12.31	0.70	-5.27	3	51	2012-10-05 13:20:37	2012-10-05 14:20:37	1	2	35	0	29	42	0	317.30	55	90.92	NEW	sh+cuuQPPssRpTRRP.sPKDPGt+tPESITFISGSAEsPPEsPACC.LsRPWVWshCKAVFCFR+CRuClQRCGuC.VRuC-sCLuusssPEuhuEtuWuKEHNGsPP..SPshAPPSRRcGpRLKsTs..GSSFSYPDVKLKGIPVYRYRsuhuPusDsDSCsKEPsAEsPPhRaSLPuTLuuS...PRSSE.EYYSFHESDLDLPELS..SGSMSSREIDVLIFKKLTELFSlHQIDELAKCTSDTVFLEKTuKISDLISSITQDYHLDEQDAECRLVRGIIRISTRKSRoRPu..TsEGRpoRsutsuGsAPDSGsDTMluSVL.SQDDLsVQISQETTSDAIAR+LRPYGTPGYPsSHDSSFQGTETDSSGAPLLQVYC	.......................................................cp.sQPPssR+TRRs..DPKDPGt+GPESITFISGSAE.sss.Es.PsCC..hpshsWshC+AsFC......Cl.pCGsC.h+uCssCLuss..-ss..Ests-tshsc-H..NGh.Ps..SPspusPsc+c..upc...hKp.sh....GSSFSYPDVKLKGIPVY.Y..s.u.h.DsDSCsKEPlscssPhRpSlss.ThssS...PRuSE.EYYSFHESD.LDlPEhu..SGSMSSREIDVLIFKKLTELFSlHQIDELAKCTSDTVFLEKTuKISDLIsSITQDYpLDEQDAEsRLVRGIIRISTRKSRsRPp.....sspG.ppp+.tutssusAPDSGpETMlsSsL.SQD-..LsVQISpETTADslARphR..sau....ssGhPhu+DS.SaQsT-TD.SSGAPLLpVYC.........................................................................	0	2	5	12
+15411	PF15552	DUF4657		Domain of unknown function (DUF4657)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NAV2	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 370 amino acids in length.	27.00	27.00	27.60	27.00	19.10	18.10	hmmbuild  -o /dev/null HMM SEED	301	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-11.99	0.70	-5.13	14	41	2012-10-05 13:34:09	2012-10-05 14:34:09	1	1	27	0	22	38	0	262.30	55	77.22	NEW	MuVGDSsLAs.PGLSQDSLshEPsGSP........EPPApluRLLAS+KLEQVLERS+pLPouPASLStpppshp..uKPcsEhslhuAGcQEuTcAEo-LEAGLEEuEVV......tGhtP-AWACLPGQGLRYLEHLCLVLEQMARLQQLaLQLQoQRP.tDPEEEEp......slAPuPsPS+sPGspVpGshEhLSQTccT.GuKsAuPsKVGsPSssPPRLsEAPsEPAHohPSSQGHKpDLSHWsKVKVLLNRIRWRSP+pPEPsAPPs..Gs.uPRhESR-.LPE+P.spshRKTFMPSLVVKKQR.AKNLSV	..........................................................................MsVGDSsLAs.PGLSQDSLshEssGSs........EPPAplsRhLASpKLtQVLERS+pLPssPsolStpppshp..sKPcpEhPlhuAGpQEuhcA-o-LEAGLEE.EsV......uuLsPtAWACLPGQGLRYLEHLCLVLEQMARLQQLYLQLphQRPPsDPtEEEp.........shAP.PsP.+sPGstspsPhELLSQTcp......T.GAcuAuPPKVtlPoANPPRLsEsPsEPsaphPSSQGHKpDhSHWsKVKVLLNRIphRS.+tPEPsAsPD..Gs.sPRh-S+c.LPE+P.spshRKTFMPSLVVKKQRAKshs.....................	0	2	3	5
+15412	PF15553	TEX19		Testis-expressed protein 19	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NA77	Family	This family of proteins is expressed in testis [1].	27.00	27.00	61.40	41.80	25.80	25.70	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.44	0.71	-11.24	0.71	-4.37	12	30	2012-10-05 13:48:42	2012-10-05 14:48:42	1	2	17	0	16	24	0	142.80	58	56.18	NEW	MCPPVShRastEGMSYLasSWhYpLQHGsQLplCFuCFKuAFL-lK-hLE.EDW.....E-E-WDsE.ME.hoEAtsEQtussG..t.uW.GpG.hp.spusS.shGsGsLssus.t.p-..hs.phVPTELtPQ-AVPLuLGsEDADWTQuLPWRhsslPsCoHWPo	..........MCPPVShRattEGMSYLYuSWhYQLQHGsQLplCFsCFKAAFL-hKchLE.EDW..........E--sWDsE.ME.hoEAtu...........EQtu..ssG....t.uW.Gpu.GpsspusS.uhGsGsLssus.s.E-h.LssphVPTELtPQ-AVPLuLGsEDADWTQuLPWRF-GLssCSHWPo...	0	1	1	2
+15413	PF15554	FSIP1		FSIP1 family	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8NA03	Family	\N	27.00	27.00	30.80	28.00	24.90	23.10	hmmbuild  -o /dev/null HMM SEED	425	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.52	0.70	-12.61	0.70	-5.66	19	68	2012-10-05 14:32:29	2012-10-05 15:32:29	1	4	46	0	43	69	0	301.10	34	73.22	NEW	DIIKGsLDuIS+PASs....SRs+PuS.RsSsu..............SLEVLoPEP...s.........htl-o.s.p.susc-................spopssssEccR.........spts.p....tt............p..phsccupD-chshsppph.sppoc-.c...........c...phDspLpcAIcKM++LD+ILs+K....h+EKEVK+QGlEh+hKLWEE.Lp.php....ppshpSsEEhcNT+KFLuLTsssppss.....ph..p.pssahsVFtTQ.....lPs-c...hEpphpphtp.chTtssppscShh+sc+p.hspppp.ch....................K+sQDFIKRNIELAKsuss.lsMhDcEK+RLtELLcDlD-tsushssspu.Dp.sshLlPGcGYT.ss.spppQLAEIDoKLQp.lssss.th...oShs.sthpspssQ....cs.hppp.psschsPGE+lLRsTKEpRD.QppRL+EI-pcLcchcEs	..............................................h.cGs.c.h.p.tts........stp.R..................slEhLss-s................hp....t.p.tpp...................tpsppp.tEppp..................s..........................hscptpcpp.sh.ptph.sttscp.c..............tphDsplpcAIpKMc+LDpILsc+....h+EKElK+psh-h+h+LWc-.lp.t......ttt.t.pcp.tNTppFLuLss..tt...........p.ptsh.slF.TQ............ls.pp....ctt.pt....s.ohcsptscuhhcst+p.hppppt.p.t..................t++spDFIKRNI...........E...........LAcputp.l.sMh-cEKcRL.ELL+Dl--tsss.sstpu........s..sshlssspGYs.ss.sppppLAEI-.KLQp..hssts.h.....s.s.st.tpp.sp.............................t.....p.tt.p.tsG-plL+ssKcpR-..ppRL+cI-ppLp.hpc.........................................	0	11	17	27
+15414	PF15555	DUF4658		Domain of unknown function (DUF4658)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8N912	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 129 and 161 amino acids in length.	27.00	27.00	88.90	88.90	22.20	20.00	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.74	0.71	-10.60	0.71	-4.27	9	27	2012-10-05 14:35:39	2012-10-05 15:35:39	1	1	19	0	12	30	0	122.60	61	69.82	NEW	hsRAtREssR+CPsSILRRS.sE+ps.GsEPQRToRRVRFREP.EVAVHYIAsRssT..sTspu....PuRPRP+tGSLLLRLoVClLLllALGLYCGRAKPlAhALEDLRApLLsLlLRLpHsALoCW+sLLpL	......sRApREssRKCPPSIL+RSpPE++pstAEPQRTSRRVRFREP.tVsVHYIAs+ssT..uTl+s..........PuRP.R...P+G..........GSLLLpLslClLLslALGLYCGRAKPVAtALEDLRApLLsLlL+LhHsALoCW+sLLpL.....	0	1	1	1
+15415	PF15556	Zwint		ZW10 interactor	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95229	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.	27.00	27.00	81.60	61.20	24.20	23.30	hmmbuild  -o /dev/null HMM SEED	252	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.19	0.70	-11.82	0.70	-5.13	8	45	2012-10-05 14:41:10	2012-10-05 15:41:10	1	2	23	0	17	49	0	188.50	66	88.54	NEW	QEEAELPAQILAEFVMDSRKKDKLLCSQLQVVDFLQNFLAQEDssQGLDPLASEDTSRQKAlAAKEQWKELKATYQEHVEAIouuLTQALs+hEEAQRKRsQLQEALEQLQAKKQVAMEKhRsAQKQWQLQQEKHLQHLAEVSAEVRcRQoGsQQELEpLhQELGsLKQQAGQERDKLQRHQTFLQLLYTLQGK.LFP....EAEAEhPQ......L-LPEDK....sQ..TpPQEQ......NTGDTMGRDtuVopKAsG.hQPAGDsoLP	....QEEAELPApILsEFVhDSpKKDKLLCSQLQVVDFLQNhLAQEDTs.puLDPLASEDTSRQKAlsAKEQWKELKATYpEHVEAIphuLTpALsphEEAQRK+sQLQEAhEQLQAKKQhAhEKh+hAQpQWQLQQEK+L....QpLAcsSAEV+pRpptsppcLpt..QcLtsLpQQAtpcp-KLQR.QoaLQLLhoLQuK..hsEu-sEh.......................................................................................................	0	1	1	3
+15416	PF15557	CAF1-p150_N		CAF1 complex subunit p150, region binding to PCNA	Coggill P	pcc	manual	Domain	CAF1-p150_N is part of the N-terminus of the CAF1 complex p150 subunit that binds to PCNA - proliferating cell nuclear antigen. The PCNA mediates the connection between CAF-1 and the DNA replication fork. The CAF1 complex is essential in human cells for the de novo deposition of histones H3 and H4 at the DNA replication fork [1,2].	25.00	25.00	37.10	34.40	21.00	16.10	hmmbuild  -o /dev/null HMM SEED	229	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.57	0.70	-11.54	0.70	-5.02	4	49	2012-10-05 14:44:19	2012-10-05 15:44:19	1	4	31	1	24	45	0	203.20	44	23.92	NEW	MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTSVQSKSPDLEASLDTLENNCHsGSDIDFRsKLVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPSREAlNG...QREDTGDQQGLLKAIQNDKLAFPGETLSDIPCKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAG	................................hAM-CKD+suhP..sKKLlQARLPFKRLNhVPKEK..s-......-t..u..-..s.....p.........s....s.S.....spS...psPD...L-...s...S...L..DsLENcCchuSDlcFpPKLVNGKGPLDsFL.pp.cl.csSl.upo..hVIIDLTEDSN..-p.s..........Du....scHscL.socASsup.cslNG....tpcstsp.u...pu.ppsphs..tET.oslPscsctt..s.t....tpp..s.t.u..shP.L....p.....t..sWSt................................................	0	1	3	9
+15417	PF15558	DUF4659		Domain of unknown function (DUF4659)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8N715	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.	27.00	27.00	32.50	31.10	25.50	26.70	hmmbuild  -o /dev/null HMM SEED	376	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.75	0.70	-12.45	0.70	-5.80	21	78	2012-10-05 14:49:01	2012-10-05 15:49:01	1	2	41	0	48	66	0	313.20	35	59.61	NEW	tslPpRD+KIsALMLuRhcctphhpE.pptAthtWEp.++p-pph+.p.E+E+phtLtQupctWppphEpR+s+h.........spEp+sptccppppsh......pE.p+W+ctsEcQEp.Rp-+l-+s..phpscp+KppQEppL+ppEchtpsh+Eppp.hthpc+hppAspK+ph+p.hptQ+clptpNh.uphlpHpAhKhhl-pQp+sEc.hh+hSLEpphp+uQEsappLlccRs+EL+EKApKE-pQhp+A+htAEcpEc.p+pc+hcsLsclu-pKlppApphuccsspcKAp+ltp.ph.+E+sp+l.KpKlEcEEcs+hctlppuIc+K-pRsEQIp+EKcsslEpuRplARAShpsR-+l+p.htspoFD+MAhEApLpAshpct	..........h.slspRDpKIsALhLsRhpctphhtE.pttAthtWEp.+tpspphp.p.E+E+phhLtpupctWptph-pR+sp..........s.Epctttccpppp........sEpch+t.s-cQp..Rtp+h-cs..ttpsch+K.pQ.ppL+ppEchhpphREptp...hpc+htpAspp+phpt.hphQ+chpphNh.uphhpapAhh.hhspQtctEc.hh+hSLEtshtRuQ...E.aptLh.cpRp+EL+E+...Ap+E-.QhppA+.tAccpEc.pppt+hchLschu-p+lppApphsccssppKsp+ltp.ph.+E+sp+h.K.KsEc-Ecs+hctlhpuIt+K.pRscplpcp+csshpphpphupAShp.+ctsht....pohDphshEApl.Ap.tt...........	0	9	14	23
+15418	PF15559	DUF4660		Domain of unknown function (DUF4660)	Eberhardt RY, Coggill P	re3	Jackhmmer:Q8N6N3	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 93 and 189 amino acids in length.	27.00	27.00	32.20	31.90	18.20	18.00	hmmbuild  -o /dev/null HMM SEED	108	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-10.14	0.72	-10.72	0.72	-3.97	14	53	2012-10-05 14:52:51	2012-10-05 15:52:51	1	1	37	0	28	47	0	103.20	61	53.36	NEW	SSDS-scupscpppt..ts.sssssSsupsttt.........hLPcPDELF+SVS+.PAFLYNPLNKp...IDWE...s+......sl+APEEPsKE......FKsWKTNAVPPPEoYssc..-pK......ssPPuhDMAIK	......SSspE.DssEPE-ssp+sss..supuuG..Gptspuc.......tRLPGPDELFRSVoR.PAFLYNPLNKQ...IDWE...RH......VVKAPEEPPKE......FKlWKoNhVPPPEoYosE....KK.....PPPPthDMAIK....	0	5	7	13
+15419	PF15560	Imm8		Immunity protein 8	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and several conserved charged and hydrophobic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family [1]. The protein is also found in heterogeneous polyimmunity loci.
	25.00	25.00	154.00	153.80	22.70	22.50	hmmbuild  -o /dev/null HMM SEED	133	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.73	0.71	-10.40	0.71	-4.49	7	13	2012-10-05 15:01:24	2012-10-05 16:01:24	1	1	12	0	1	11	0	133.00	45	92.86	NEW	MElhlssVlGGplssp....+slpsllhcMRKplKcpFtshphEuLs+hKIslahSGDlSpYsspoGIhpsRYapcKKEalspFCID+phWoup.h.Dlp.KFLhhlps.hlpLGslI+pKLcptsYsFDschaK-hl	MElslshVhGGplssp....KslpshlhpMRK.lKcoFpsh-.EulsphKlsLahsGDlSSYhspTGIYQsRYastKKEalspFCIDRspWousKhcDls.hFlhhlpshhIchGsLIcpKLtKhpYsFDhpsYKchV..	0	1	1	1
+15420	PF15561	Imm9		Immunity protein 9	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and several conserved polar and hydrophobic residues. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1]. 
	25.00	25.00	34.30	33.70	21.70	21.00	hmmbuild  -o /dev/null HMM SEED	160	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-10.86	0.71	-4.64	5	11	2012-10-05 15:02:01	2012-10-05 16:02:01	1	1	10	0	1	10	0	140.10	38	90.75	NEW	KIlTspt.......hcEIpchlc.+sstFEEIPIIoRasRtchLp+sIu+E-lslaLLNlALFaLNNIpLaA+clLsp.psssLFICITlVD...lE-EhsDl.GFsIPNILIS+cK.htsplppcstlNL-cpcaLpcphupluhpshFphY+opoDDGaGt-IhRIYllPK	..Kl.+shQ.cpI.phlt.hsstFEEIPIIophtR.chhhcshu+c-hslhhLNsuLFhLsNlpLhs+clLspppppsLFhCIThss....p..hsDl.GF.lPNIhISppt.hhphhppt.thslcp..aLpp.hppluh.shFthhhshosDsaG.-hhRlallsK................	0	0	0	0
+15421	PF15562	Imm10		Immunity protein 10	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with two transmembrane helices, and a WxW motif and a conserved arginine between the two helices. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1]. 
	25.00	25.00	27.00	26.70	24.40	23.70	hmmbuild  -o /dev/null HMM SEED	61	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.85	0.72	-9.14	0.72	-4.21	46	149	2012-10-05 15:02:37	2012-10-05 16:02:37	1	2	105	0	21	102	0	59.30	30	73.33	NEW	llhlhlGllhLluuIhsWcWhhssp.ss......ph.....hl.chhGcpshRlhh.ul.lulllIhsulhha	....lhlhlGllhLluulhsWc.Wh..asspss......ph.....hl.cphG+pttRlhh.ul.LGlllIshulahF......	0	4	16	18
+15422	PF15563	Imm11		Immunity protein 11	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved HxxRN motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1]. 
	25.00	25.00	65.90	65.60	22.00	21.60	hmmbuild  -o /dev/null HMM SEED	224	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.48	0.70	-11.53	0.70	-5.25	3	9	2012-10-05 15:03:45	2012-10-05 16:03:45	1	1	9	0	2	8	0	221.80	47	96.85	NEW	MN+IpshEhshSNshFWNFhhsaa.RGaDEE+EsNlDEVh-......lVEscchKuY.W..sWFsQlDlKTsEsttElE..NPRTlshPIsDDlsaslEFHPsEThYFlNDTYIGNlGGHFHLpaLTaoELhuI..pcEKYuSLLFaLLLPLTuIcEsEKsIl+sEIspHLpcIPlFKsHSsYIuDC..ILNGLllu-SsFQppcGIGhlsspNHShRNthsY---+csIpELN+LLV+	.MNhIpphEhshSNshFW.Nhhhpaa.cuaDEE+DsNhDEVh-......ll-pcchKpY.W..sWlsQlDlK....TsEspGEIE..NPRTlsLPIssDlsholEFHPssThYFLNDThIGpluGsFHL+aLTaoELhcI..TcEKYuslLFaLLLPLouI+EpEKshhhstIhp+LppIPlFKpHSsYIucC..ILNGLllusSshQph.tIGhlsspNHShRNthhY---+ppIpELNhLLs+...	1	1	1	2
+15423	PF15564	Imm13		Immunity protein 13	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in heterogeneous polyimmunity loci of polymorphic toxin systems [1]
	25.00	25.00	235.30	235.00	19.80	19.00	hmmbuild  -o /dev/null HMM SEED	131	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.69	0.71	-4.44	2	3	2012-10-05 15:04:31	2012-10-05 16:04:31	1	1	3	0	0	3	0	131.00	66	79.39	NEW	.ps-FtSVlsEFtpLls-asFpCPcKLWYssLlsLSKpl.DIYYCYlIsRVYKpsGSLEsThWVGsIsRPDDGLENLSANIKhQIGYsQshD.hFF+pCESKIl.lIESG.LhsLlssSQ.EhKh.ShHNh	..oDDF+SVVAEFGNLINDFGFSCPEKLWYsNLISLSKNVcDIYYCYVIARVYKsDGSLETTLWVGPINRPDDGLENLSANIKIQIGYTQVsDPLFFRNCESKIIsLIESGILKTLLssSQNELKaPSIHNh.	0	0	0	0
+15425	PF15565	Imm16		Immunity protein 16	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly alpha-helical fold and a conserved DxG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-SHH family of HNH/Endonuclease VII fold nucleases [1].
	23.00	23.00	23.00	24.30	22.10	22.20	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.55	0.72	-10.30	0.72	-4.18	6	55	2012-10-05 15:06:40	2012-10-05 16:06:40	1	1	47	0	13	56	0	98.40	38	65.46	NEW	ccLhuscphtsQs-CccF.ullcAlpcpl-tcllcsLLpTFuDc.cDa.GlQ-plVpVl-ps-sphahsclstthsplh-pAs.+EWAhhLlGRllNSsstcpthttlh	....................Lhp.Rhhcsp.p-.h.c.FppsLtclhphsssplIs-LCllh-D-.....pp......-VMFsLlahlE...p.....th...-ct...LhplsculP+MlpsA...EWsclLahRILNscthR.tYscl.h.........	0	0	5	7
+15426	PF15566	Imm18		Immunity protein 18	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved histidine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox12 or Ntox37 or Notx 7 families [1].
	25.00	25.00	51.80	51.40	22.60	22.10	hmmbuild  -o /dev/null HMM SEED	52	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.89	0.72	-8.63	0.72	-4.63	9	13	2012-10-05 15:10:02	2012-10-05 16:10:02	1	1	13	0	6	12	0	52.50	36	65.01	NEW	tcGLthLhcpLppLps+.....spHhHLMTsuWuGsELo....-ppQupcs.pLlsHl+l	..-GLchLtcplppLtp+.....scHhHLMTPuWGG-ELo....EccQup-s.pLlpHl+l.	0	3	4	4
+15427	PF15567	Imm19		Immunity protein 19	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a protease domain such as Tox-PL1 and Ntox40. In some instances, it is also fused to a papain-like toxin, ADP-ribosyl glycohydrolase and a S8-like peptidase [1]. Based on these associations the domain is likely to be a protease inhibitor.
	25.00	25.00	31.20	30.50	23.40	22.30	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.87	0.72	-3.98	20	224	2012-10-05 15:12:48	2012-10-05 16:12:48	1	6	217	0	16	64	2	85.00	73	70.53	NEW	hccAhtpAppaLpt....ss-hs.........lll..ststchshGWlFsasotcaLcoGD.tspLsusuPllVc+ssGclt.........shusspP..htcalpcacspt	.................Y.HDAFAKANHYLD.....DADLP.......VVI..TLHGRFSQGW..YFCFEAREFLETGDEAARLAGNAPFIIDKDSGEIH.........SLGTAKP..LEEYLQDYEIKK............	0	8	11	13
+15428	PF15568	Imm20		Immunity protein 20	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved GR, and GxK motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family of nucleases [1].
	25.00	25.00	43.50	43.50	24.40	19.30	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.71	0.71	-10.48	0.71	-4.25	2	3	2012-10-05 15:13:23	2012-10-05 16:13:23	1	1	3	0	1	5	0	96.70	50	94.16	NEW	MAcpRhhl.GGVuLhhGRV+pu..shh..pDclE.hL.D.sFhp-hPFKhluhlhhaGpKs.LhPpY-.INK+au-LPltlELchthLchAsp...-llhshFhhusl-sLlcVucKYtLPst.Lcp.suh	MAHNRKYVPGGVALVMGRVRNS..GKVVEQDElE.hL.D.sFhp-hPFKhluhlhhaGpKs.LhPpY-.INK+au-LPltlELchthLchAsp...-llhshFhhusl-sLlcVucKYtLPst.Lcp.suh...	0	0	0	0
+15429	PF15569	Imm21		Immunity protein 21	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved phenylalanine and tryptophan residues and a GGD motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox19 family [1].
	22.20	22.20	24.20	24.20	20.30	17.50	hmmbuild  -o /dev/null HMM SEED	91	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.39	0.72	-10.12	0.72	-4.21	11	48	2012-10-05 15:14:00	2012-10-05 16:14:00	1	1	45	0	6	26	0	84.30	53	77.70	NEW	sLt.lGltphAashpDsLchlshhcppphsILGGDVYphpsstlclTYDuWaas...cpss-sshp...psh.hAh-YIspYhs..psup.phlasl	.......s.LhulGIcEsAhPlshAIDILNLalsERILVLGGDIY.IKKDN..YFYQTYDNWYYE...GSNLFNSI-.......KAMHYLSQlKhENAYVSFV...Lph..............	0	3	6	6
+15430	PF15570	Imm24		Immunity protein 24	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold with conserved tryptophan, proline, aspartate, serine and arginine residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-AHH family of HNH/Endonuclease VII fold nucleases [1]. The gene for this toxin is also found in heterogeneous polyimmunity loci.
	23.40	23.40	24.10	27.00	22.00	22.60	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.95	0.71	-10.69	0.71	-4.39	11	23	2012-10-05 15:15:18	2012-10-05 16:15:18	1	1	15	0	11	23	0	119.60	29	55.27	NEW	hshpW.......aphs.stphs.......p.....hPppLa.lCs++hctLpFDah..as.shaIlS-cFlchlpchphspphptshlplss+cGc.pls.cchYYhlRhhahsp-.F...ctSph.pp-hpcsh...........l..Y.clpL+-ps.	....h.phpW.......apspstth........phPspLYhlCsKKsttLpFDah..as.phhIlS-cFLchlpc.shsccashupltlls+Ksc..ls.cchYYhlRl.ahsp-.Fh..ct.ph.pp-hpcpl...........l..Y.chpL+-psh......................................	0	0	7	11
+15431	PF15571	Imm25		Immunity protein 25	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI1, Tox-URI2 or Tox-ParBL1 families [1]. The gene for this toxin is also found in heterogeneous polyimmunity loci that show variations in structure even between closely related strains.
	25.00	25.00	27.10	27.00	23.00	22.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.77	0.71	-10.81	0.71	-4.01	3	30	2012-10-05 15:15:50	2012-10-05 16:15:50	1	1	30	0	3	20	0	125.40	37	95.19	NEW	MKaFIGGEIE....psIsDKFR+sRNsV.....I-aLDsL.GscIpSINElSFhVas.LKcFphsPlo+YpKKpNRlELEIhI-F-pFEsANDspssELLKQsILAVIpcYcNKsI.psSlDlIhoKlEsEIpp	.M+hFloGELE....psIu-c....FRcsRspl..........hch..ssh.ts-l.ppIs..lshhVhh..hKpap....t.pEhphap+Kppch-hRLhI-a-pF.oANDSppspLllpsIlpuIcpht...sKs..pp.h-s...KhctsI.......................	0	1	3	3
+15432	PF15572	Imm26		Immunity protein 26	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved C-terminal tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-ColE3 family [1].
	25.00	25.00	26.70	26.50	22.20	18.90	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.61	0.72	-10.12	0.72	-3.86	19	24	2012-10-05 15:16:50	2012-10-05 16:16:50	1	3	21	0	11	26	0	95.40	35	75.88	NEW	hKLl-apschlpRGslhRhsut...............aPaE.clVDFMVh-h.s..tt....shuLllsSGaKAGhlh.hhhPpEuhsppst..ulSTpWllcNWp+WlYscCslccVal	.....+Ll-atschlpRGslhRhsuh...............aPa-.plVDFMVh-t.s.tt....shuLllsSGaKAGhlh.hhhPpEuhsppsh..ulSopWllpNWp+alYspsssccVhl....	0	2	8	10
+15433	PF15573	Imm27		Immunity protein 27	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved KxGDxxK motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1].
	25.00	25.00	26.20	101.60	23.80	18.10	hmmbuild  -o /dev/null HMM SEED	259	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.79	0.70	-11.50	0.70	-5.18	10	46	2012-10-05 15:17:35	2012-10-05 16:17:35	1	1	40	0	5	43	0	234.00	55	96.89	NEW	sLhsuIWaG-loshols-LKpsLLsspTE+EsllLIlELhKtGDFoVKsLLIpLMNpTcDEsVLNLCIRLFCSVuTHDDL+-oNNL+FLusASEhuVaTFsuuAlsTLSYEVIPYLLsLLEEWE-..oDlEhuIRDuLDhFLNacspluE-ATlEElGshYh-hlcspDhspYYY+ssLAFPGDLTKcLhpclhlAAp+EEpa+hhlIPSLLSIaTGEKVPlDhcTIIoscch+chlsYIDsLocKsWccGpKYFYGahV	..LhpsIWaG-ho.hshpplKpplhcusTEpEslh.lhELhKtGDFo.KsLLlpLMNpT+DEsVLNLCIRlFhSVATH-DLc-oNNL+FLSpsoE-sVcTFsuuAssoLShEVIPYLLALLEEWE-..o-stphIRDulD.alsacDpluE-Aol-ElGphYhcaspppDsppYYapppLuFPGDLsKclhpcVMhAApsccphph.lIPSLLSIWoGh+sPh-YsTIIospph+-hhsYIs.LopcpWccGpKYFYGahl.....	0	1	4	4
+15434	PF15574	Imm28		Immunity protein 28	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an all alpha-helical fold and a conserved HRG motif. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1].
	25.00	25.00	70.50	70.40	22.30	18.30	hmmbuild  -o /dev/null HMM SEED	123	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.59	0.71	-4.56	8	15	2012-10-05 15:18:14	2012-10-05 16:18:14	1	1	15	0	0	16	0	117.70	43	93.88	NEW	alsEuhphsschlphlpl..DlpDE......hpRQlluuYlFGhLNuLAh-cshsPsDlQusMIclhIcpLsYsspsAsphspFlIcuTDKpFHPThaAIIHRGlEGYahYp-c.+.s-LpcDFp-IlpllK	..lsEulchlschlpllpl..DlpD-......h-+QllAuYlFGMLNGhAa-csIsPsDlQuhMIcIuI-KLsYosEsAsQhoQFlIcuTD+pFHPThaAIIHRGlEGYahYp-p.c.ppLpcDFp-IlpllK.	0	0	0	0
+15435	PF15575	Imm29		Immunity protein 29	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an all alpha-helical fold and a conserved proline residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-REAse-1 or Tox-REase-6 families [1].
	26.00	26.00	26.00	26.30	25.30	25.50	hmmbuild  -o /dev/null HMM SEED	215	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.74	0.70	-11.29	0.70	-4.73	81	217	2012-10-05 15:19:04	2012-10-05 16:19:04	1	2	129	0	57	210	3	198.40	19	70.51	NEW	csshsph...cphthhssthphhsshhtsst...........................h............h...s.t.hhs...sts........Wh..ssh..hhAllscspp.hhshLsphss.........ph.hppstsths..............hshshhttLpshhhsps......shhcplhpthp..tsts.....................phhpthhh.s.hphahslh...p.pDpssappuLtptLph+pthhttpcttt............sscs...........hlshhsluhAplAacp.G.....hplpl-SsYlPppLl	...................................................................tth.hh.sththht.h...t..............................................s.....hs...hhs........h...ssh...ahslhscs.p..hhchLsph.s.........sh.hppspshhs.............thshshhhhhpshhhsps......t.hccLhpphpts.hs.............ts..tchhpphhh...hchhhuls...p..pDtpshctuLpthlch+pthhttpcp.p............hhct...........alshtllshAplAhpp.G.....hplsl-sthlPptLl................................	0	11	28	42
+15436	PF15576	DUF4661		Domain of unknown function (DUF4661)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95873	Family	This family of proteins is found in eukaryotes. Proteins in this family are typically between 281 and 302 amino acids in length.	27.00	27.00	56.40	29.50	24.90	24.50	hmmbuild  -o /dev/null HMM SEED	253	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.85	0.70	-11.68	0.70	-4.73	7	26	2012-10-05 15:20:41	2012-10-05 16:20:41	1	2	20	0	13	29	0	232.20	69	83.25	NEW	RRKss+PD.ssPEsRhhDSSPENSGSDWDSAPETMGDsGPPKsKDSGsp+ssGsAPE.SR....csps-QLGS+RMDShKhspsssshpEStRLEAuGslsplGpDPhsusGshc.tVs.Etthss.GPEAPVEKsuR+Q+LLGWLpGEs....GAPspYLGsPEEhLQISTNLTLHLLELLASALLuLCSRPLRAsLDALGLRGPLGLWLHGLLSFLAALHGLHAVLSLLTAHPLHFACLFGLLQALVLAVSLREP	.............RRKsh+PD.PsPEPRplDSSsENSGSDWDSAPETMGDVG.PKTKDSGshRsStAAsEPS+....EspVEQLGS+RMDSLKh-pssSsTQESGRLEAGGA.P+LGhD.VDSuGs++sGVSPEGshSsPGPtAPlEKPGRRpKLLGWLRGEP....GAPspYLGG..PEEsLQISTNLTLHLLELLASALLuLCSRPLRAALDsLGLRGPLGLWLHGLLSFLAALHGLHAVLSLLTAHPLHFACLFGLLQALVLAVSLREP...........	0	1	1	1
+15437	PF15577	Spc7_C2		Spc7_C2	Coggill P	pcc	manual	Family	Spc7_C2 is a short family to the C-terminus of fungal Spc7 proteins. The Ndc80-MIND-Spc7 complex plays a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle [1]. The N-terminal region of Spc7 co-localises with the mitotic spindle, and it has been argued that Spc7 has the potential to associate with spindle microtubules and that this association is regulated by the C-terminal part of the Spc7 protein [2,3]. However, this family represents only the conserved region towards the end of the C-terminus; the majority of the C-terminal part is in family Spc7, Pfam:PF08317.	22.30	22.30	24.00	22.90	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	67	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.17	0.72	-8.70	0.72	-4.32	16	47	2012-10-05 16:37:54	2012-10-05 17:37:54	1	7	47	0	42	48	0	66.50	29	5.52	NEW	hchLs.lpptWspuphlsp-l+tlphpaP.ssssc.so.Dpolplpss.lhlsslco+Vclshslst.pltp	.....t.plLphVpsuWspAptlsppl+hlshsaPTsls.......c.oS..Dsol...sls....uS.lLLsslpT+VclshsLpt.....p........	0	10	26	37
+15438	PF15578	DUF4662		Domain of unknown function (DUF4662)	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95567	Family	This family of proteins is found in eukaryotes. Proteins in this family are approximately 290 amino acids in length.	27.00	27.00	201.10	200.90	20.20	19.60	hmmbuild  -o /dev/null HMM SEED	270	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.95	0.70	-11.76	0.70	-4.81	8	21	2012-10-05 16:38:14	2012-10-05 17:38:14	1	1	20	0	13	24	0	259.30	75	91.71	NEW	HPIYVRR-PSIPTYGLRQSILLNTRLQDCYVDSPALTNIWsuRTCAcpNIpAPsPGTTSSWEVVKNPLIoSSFSLVKLVLRRQLKDKCCPlPsKFG.EAKspK..RLKsKDsSssKAT.puRhRNSIssKSKpPuGQhPG..SscpR+PAGulpESKESSKEKK.uTVsQDLE-RYAEHVAATQuLPpDotTAAWKGQA.LPETpKRQpLSEDsLTIHGLPsEuY+ALYHuVVEPMLWNPSGTPKRYSLELGKAIKQKLWEALCSQAAsPEsAQcD	............HPI.VRRDPSIPhYGLRQSILLNTRLQDCYVDSPALTNIWhARTCAKQNIsAPAPuTTSSWEVV+NPLIASSFSLVKLVLRRQ.LKsKCCPsPpKFG.EuK.SK..RLKpKDsSshKATQpuRhRNSISSKSKpPAGp.........RRPAGGIpESKESSKEKK.lTVRQDLEDRYAEHVAATQALPpDSGTAAWKGpsLLPETpKRQQLSEDTLTIHGLPTEGYpALYHAVVEPMLWNPSGTPKRYSLELGKAIKQKLWEALCSQuAhsEGAQ+D..	0	1	1	1
+15439	PF15579	Imm32		Immunity protein 32	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved tryptophan and phenylalanine residues, and a GT motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-REase-5 family [1].	25.00	25.00	36.10	35.90	22.60	22.50	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.24	0.72	-4.45	36	138	2012-10-05 19:59:56	2012-10-05 20:59:56	1	1	70	0	44	152	0	95.40	43	46.47	NEW	hpllpsls.ttasshalplsspsY..hpcpVF.sD+suVGWMLYLP+hITtpQVPEApsLlPV.ssscp..pGTIIVS.TDtsFoscNsEHlchANcIEIRLlDtsLL	....................h..hlpshh..hhps.hh.sssptY....hpcplF.sD+.uVGWMlYLP+hloppQVPEAcALIsVss.....t.....scp..pGTIIVS.TDsPFoscNPEHVtlAN+IEIRLlDtsLL.	0	4	9	25
+15440	PF15580	Imm33		Immunity protein 33	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved tryptophan, and WE and PGW motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox24 or Ntox10 families [1].	25.00	25.00	60.60	59.90	21.40	19.50	hmmbuild  -o /dev/null HMM SEED	90	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.66	0.72	-10.18	0.72	-4.50	33	42	2012-10-05 20:00:33	2012-10-05 21:00:33	1	2	40	0	18	47	1	89.90	36	81.91	NEW	lpWLpcWYtspCDG-WEHpaGlcIsTLDNPGWplpIDLscTshpshpht.lplcps..........c.sDWhtsplcssp.....FpusuustpLpclLphF+pWl	..lpaLQsWYtspCDG-WEHpaGlpIsTLDNPGWplpIDlspTshttpthtplplcps..........c.sDWhtsplcstp.......FpuhsusppLpclLphFhpW...........	0	7	12	16
+15441	PF15581	Imm35		Immunity protein 35	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and YxxxD, WxG, KxxxE motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene [1].	25.00	25.00	137.30	137.10	21.80	19.90	hmmbuild  -o /dev/null HMM SEED	93	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.26	0.72	-10.04	0.72	-3.97	4	5	2012-10-05 20:01:14	2012-10-05 21:01:14	1	1	5	0	3	5	0	93.00	41	86.43	NEW	l.sslhhAYhhlD+SIoLoYhpQuhEoucuslcsLppLIEcEWRGLsptQVh+KLcsVAtppsttchVlK+..EsslIWF-pVRFpFspGRLspV	VssslhFAYhWIDRSISLSYucQGpETAcuoV+sLppLIE+EWRGLPEsQVh+KLcAVAApustu+IVVKK..EGslIWFD-VRFNF--GRLcSV	0	1	3	3
+15442	PF15582	Imm40		Immunity protein 40	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved YxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-JAB1 family [1]. The immunity protein typically contains a signal peptide and a lipobox.	25.00	25.00	33.10	32.00	18.90	17.60	hmmbuild  -o /dev/null HMM SEED	327	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.11	0.70	-12.17	0.70	-5.73	2	16	2012-10-05 20:02:21	2012-10-05 21:02:21	1	1	13	0	1	14	0	222.90	40	87.58	NEW	lpQtVttQsclLlDSGhlhspYl.l.Elh.sDSNplY.IttuDsPus.thEhPS+lIKYK-+YLCFIELDEs.MStpEhhEt.....SsaptNLslp..tG+sWLLslpKht-K+ILlch...hhh..hFphsELWsYFSG.l.ptpss.MGlhSHDl.lssSYlss.h-..hcsL.......pshlcph.Gphal+NpTDSVlhLSpsot+p..YAVlsG.DoLhLsLpDSLPlhluPp-hK.LcYcS.P.ps..Fhp.h.ccD.W..hYpLFscSTasFlNlNsh.pph+lMapD.ssYu.slp.o.sph.h.IhN+GlYDKc.t.hphF+a.	....................................................lpQtVttQsKlLlDSGhl.s.Yl.l.Elh.NDSshIY.IpsADsPus..thEhPSKllcYKs+YLCFIE.LDE..MStpEhhEt.....SsaptNLhlp....csWlLslpKhtptphLlch....ha..hFphspLW...............................................hshlpph.GphahpN.hDphhh.spsoh+p..aAVlsG.DoLhLsl.Dols........p..........................hYpLhtcSTa.hhs.psh..thpl.apD....a......t..s..h...l.pcuh..........................	0	1	1	1
+15443	PF15583	Imm41		Immunity protein 41	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved glutamate residue. The domain is often fused to one or more immunity domains in polyimmunity proteins [1]. 	25.00	25.00	30.00	39.60	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	158	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.92	0.71	-4.42	13	63	2012-10-05 20:02:45	2012-10-05 21:02:45	1	12	59	0	9	44	1	147.30	48	27.96	NEW	MYI-.KYWGsaIGGoDDSLsLlsYLtspc+-cIoLsEIFsDhGLDcL.....shsF+pTsp..ltap....sp-G.h-h-FcaAIDllsDLAAllLECptsGpVsLp-L.t.ss.psRhIRIsAosEEhshlspALtDFspsPhcYDLsEMhs--DhtEhApcs-pLRpEL	....MhI-.pYWGpahGsSsDShsLspYLtspc+E.lslsEIFpDhsLDcL.....shNapps............phDG.sthcFc.AhplVhDLAsLlLEsctsGphNLtcl....tss.sRhhRIsATsEEhhslshALpcFAhuP.-YcltEhhD--.-hhEhuphsEplRtpL.......	0	3	5	8
+15444	PF15584	Imm44		Immunity protein 44	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly all-beta fold and GxxE, WxDxRY motifs and a glutamate residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox48 family. This domain is often fused to the Imm71 immunity domain [1].	25.00	25.00	28.90	51.50	22.40	17.10	hmmbuild  -o /dev/null HMM SEED	94	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.68	0.72	-10.36	0.72	-4.13	17	44	2012-10-05 20:03:57	2012-10-05 21:03:57	1	2	19	0	19	51	0	100.50	46	32.10	NEW	sFPssLPtlP..s.stssllpSGcclPssGIWEPhss.psKl.................GChNYhltGohAPphttpsss.................pthsspWRLlWEDpRYpDGoIP-EEpsYlh	.......hFPssLPcVP...pstsslIpSGpclPC-GIWEPVshtpsKlhulhsh...spt.h..sGChNYFltsstAPphtp-sss.................t.lsspWRLLWEDcRYtDGsIP-Epphal....	0	0	0	5
+15445	PF15585	Imm46		Immunity protein 46	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved GxaG motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Tox-REase-3 domain [1]. 	25.00	25.00	27.90	27.60	21.20	20.20	hmmbuild  -o /dev/null HMM SEED	129	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.79	0.71	-10.43	0.71	-4.09	17	27	2012-10-05 20:04:40	2012-10-05 21:04:40	1	1	21	0	9	26	0	115.60	35	94.69	NEW	MaEaHGWhTIptospppDs...tph-pllsclpphlschshs.......shlcLphhNGphhlphuGhsNH+spph.pllslappluclAPGSYGLLYh+DDE..-.....thsNpFRVahhtRGplocppDsaLSPslPhlED	........MhEaHGWholptostttDp...tp.cthhpclpthlschsh........shlsLphhNGphhlphuGhsNH+st.h.pllslappluclAPGSYGLLYh+DDE..-.....thsNpFpVhhhsRGplspppDsaLSPslPslED..	0	5	8	8
+15446	PF15586	Imm47		Immunity protein 47	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved Wea (a: aromatic) motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox7 family [1]. 	26.90	26.90	28.30	38.20	25.30	25.40	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.60	0.71	-10.38	0.71	-4.26	29	121	2012-10-05 20:05:12	2012-10-05 21:05:12	1	1	87	0	25	68	1	107.40	38	93.43	NEW	+splKulpss..chs...LcsahP-csssFshhlplpIGs.pspp.Gu-.FplhlCTPcWLppphtptthh.htR+hLlVpc.Y.chcpIhshlpchlspCpupsWtclupKLuRhhtWEaEDYp	...........+lcLKshsh...DhD...hEcFsP-h.-NFphhlsLsIGh.-spp.G.ush.FplhICSPcWlpp...phpc.t..h......h...pstllhpp.a.shchIhp.IscIL-hC.sp.poW-cohspLtRaFsWEFEDYp....	0	7	14	22
+15447	PF15587	Imm48		Immunity protein 48	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved lysine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-URI2 family [1]. The protein is also found in heterogeneous polyimmunity loci.	25.00	25.00	35.30	35.20	20.70	19.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.17	0.71	-10.98	0.71	-4.84	7	30	2012-10-05 20:05:35	2012-10-05 21:05:35	1	1	29	0	2	21	0	153.90	43	97.65	NEW	Mc.clpl...hl..plPpL.Ehsslcsl....+.tLpsalpslhstINlpc.Ls-WpLhlhl...shhus..NtIGlaK+uppaoSsKEhphSIulslPspccshaGlsch.cpuahs.lscppFh....lLpss.FspYsNLtcYIlEsuKluIh.hhppGhphpGhKIph.	..................Mp.Qltl...LlssplspLhEhspl.pl....pc.lpsYhpDlsNtIphD-.L...sDWpLhI.l...shhss..stIGIaK+uh.pasSsKEhploIuIPlPspcpsRaGlsch.....puahs.lsccsFh....lLsss.FuKYDNLhpYIl-suKhAIhshFphGFThpGhKIKK+.	0	1	2	2
+15448	PF15588	Imm7		Immunity protein 7	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly all-beta fold and a conserved arginine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a Pput_2613 deaminase domain [1]. The protein is also found in heterogeneous polyimmunity loci.
	25.00	25.00	32.80	31.90	23.80	21.70	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.20	0.71	-10.31	0.71	-4.05	32	42	2012-10-05 20:13:00	2012-10-05 21:13:00	1	2	40	0	14	45	1	117.50	21	78.64	NEW	.hpFpAphlsspt-sc...hhhlGhAD.cc.ssppallhQRsh....c-pDtptshsuha..sps....sstssYsslcplpLppspltlplpssshh.....slsls..plplsh........ph......hphhpphhpplLp.	...thpFpAphlssph-sc...shhlGhAD.cc.ssppYlllQRsh....--pD.p.shssha..hch...tsspssYsslccltLppsplhlplpcss.t.....slshs..plplsh........sh.......hphlpphhpplhth.........	0	5	8	12
+15449	PF15589	Imm12		Immunity protein 12	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved WxG and YxxxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the NGO1392-family of HNH/Endonuclease VII fold nucleases [1]. 
	29.00	29.00	32.50	32.20	25.70	24.20	hmmbuild  -o /dev/null HMM SEED	155	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.41	0.71	-11.09	0.71	-4.46	17	45	2012-10-05 20:14:09	2012-10-05 21:14:09	1	1	43	0	16	45	1	144.10	33	88.74	NEW	pWVEShGGPLlsVPtosLshWsGss........s.spsssDYDRACsVDGhsGllslGs..up.....ALVLGDEPAsTsYL..PcHtsF..lRW......hAADS.....Es-Llusscssls..uspW-..spspWpss...GPsVLhDuA..........aPG.usss...sphtVsLssGRatVRAscscs-tcoh.	..........pWlcotGGPllhl.psshthWpGsp.....................s.sDYsRACsVsshlGllslss..tp.....ALVLGDEPhsTsa..l...scc..tsF..lRW......hsA-s........Es-llsuscsshs....sstWp..spsp..Wpss...GslVLFDSA..........hPssphs...spl.lsL...sGpatV+ssphpss..s..............................................	0	4	10	15
+15450	PF15590	Imm15		Immunity protein 15	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved aspartate and GGxP motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox10 or Tox-ParB families [1].	25.00	25.00	69.80	69.60	19.20	16.70	hmmbuild  -o /dev/null HMM SEED	69	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.74	0.72	-9.29	0.72	-4.89	5	9	2012-10-05 20:14:46	2012-10-05 21:14:46	1	2	9	0	1	8	0	69.80	37	13.46	NEW	Dsls-RIEsLIsNp..LpclAh.....pPD..uWEsLYpDPcDGRaWE+lhscSchcGGGPPpLpslSQsss+s+Ypl	..Dsls.RIcsLlsNp..Lpcluh.....pss..GWpphapDPsDGRaW.hshspSchcGGGPPpLpslSQ.ps+spYph.....	0	0	0	1
+15451	PF15591	Imm17		Immunity protein 17	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly all-beta fold and a conserved GxS motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox17 or Ntox7 families [1].
	25.00	25.00	73.40	73.30	23.10	21.00	hmmbuild  -o /dev/null HMM SEED	74	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.67	0.72	-9.27	0.72	-4.21	6	26	2012-10-05 20:15:26	2012-10-05 21:15:26	1	1	26	0	3	9	0	77.40	76	97.53	NEW	M...KhsFYp.Vclhp..ssst.....cltGc+GVVlGhSE-DsthaGYuVlIa.-hcpsh.l-cc-ltsTGphhsR--FY	..MTNLKLDFYSEVIIKDSCPNDLLENGETIKGKKGVVLGISEEDGIIYGYTILLF.DIKYCIYIDKKYIIPTGKKFSRDDFY	0	1	2	2
+15452	PF15592	Imm22		Immunity protein 22	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved SF motif and tryptophan residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox21, Ntox29 or Tox-ART-RSE-like ADP-ribosyltransferase families [1].
	23.30	23.30	25.40	24.90	21.70	21.50	hmmbuild  -o /dev/null HMM SEED	116	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-10.65	0.71	-3.77	13	133	2012-10-05 20:17:06	2012-10-05 21:17:06	1	1	76	0	12	78	1	110.90	58	90.11	NEW	+Nlsps.pa-EsSFIuplh-pupWscccYW+LEpsLhpl...sp...phphsc-lspplhhuhhpllshlh.thsstc.apIps..h...........cshc....I.shhERhchlhptlFs..scslcpstF.hh	............RNIPsFEcYDENSFIGKWYD.DGVWDDEEYWKLENsLIEV...R+...KYPYPMDIPRDIVIGIGTII-FLM..VsNWKLFcIKu..SP.......WLPcSVt....IpERYERh+sMLRYIFT..-hDl.NspF.Y.....................	0	5	8	9
+15453	PF15593	Imm23		Immunity protein 23	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Ntox18 family [1].
	25.00	25.00	26.00	25.80	24.40	24.00	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.98	0.71	-4.00	26	70	2012-10-05 20:18:30	2012-10-05 21:18:30	1	1	56	0	16	50	0	150.50	23	94.87	NEW	MIaG-...P.pFulhh-h.lppWs.sss..a.....ppGhFsaaIsuchhPs.hhsso..LtssltpL..pph..........thhsthpsppLFshsstchhphl..............hphh.sphts....pt.ch.......aphhloh..shsDs...Gh.lFh..lps.s-ph+llatp.................pstslp..-hhLptsphppllppl.t	.......hhGp....pcFuIhh-p..pchs..ts..a.....h.GhhphhIssphaPp....t...hho..LssshpsL..csp..........th.pphhssthhsL-htc.thh.l...............hchsp.phss.......ph.......hshhhsss..shp..-...shslhh..hps.s-p-RLhath..................sspshc..Ehhhc+Gplppll.pl.p.......................	0	2	7	11
+15454	PF15594	Imm30		Immunity protein 30	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an all-beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-HHH or Ntox24 families [1].	23.20	23.20	25.00	25.00	21.40	21.10	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.90	0.71	-10.47	0.71	-4.03	40	70	2012-10-05 20:22:57	2012-10-05 21:22:57	1	1	61	0	24	80	1	120.60	23	86.37	NEW	pplhssptlpplasp.hPshpcsclhslplc+pss.........pLslph.....hhpchsps..Pp+W..spass........hhlslsFhslppLpl.....suhuppshlsplplppssst.h..........plslps.sssh......phpC....cahplpsls.sa	.....hhssptlhslaGp.hPshccs-lhslplpRsss.........pLslph.....hspc.spsh.Pp+W..scass.........hhlplsFhslpsLpl.....puhuspsllsphclp.ph--p.h..........hlcIcs...psph......hlpC....cahclcsls.s.................................	0	4	11	16
+15455	PF15595	Imm31		Immunity protein 31	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved tryptophan and Dx[DE] motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the Tox-RES or Tox-URI1 families. Proteins containing this domain are present in heterogeneous polyimmunity loci in polymorphic toxin systems [1].	29.80	29.80	35.20	34.10	25.50	25.00	hmmbuild  -o /dev/null HMM SEED	107	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.34	0.72	-10.41	0.72	-4.28	33	97	2012-10-05 20:23:36	2012-10-05 21:23:36	1	2	91	0	16	77	0	106.30	27	70.46	NEW	p.hhhlcpc..tshslsL.l.tctchp.hsp+hc-..Gh-u..sGYsWtulhpsalpcct..PcL..h-clcaDPEAGhFsA.Y....upst-sLcchsthlcchh-scphlhcll..pts-lp.	...................................h.lhphp...shslsh...pppcshthsphhpp..shcu..sGYsWcuhhphalpcht..Pcl..h-thphDPEAuhFsA.Y....upsh-slpclsphlpshh-s-chlhphl..pts...t...........	0	5	12	14
+15456	PF15596	Imm34		Immunity protein 34	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly alpha-helical fold and conserved aspartate and cysteine residues and an SE motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the LD-peptidase or Tox-Caspase families [1].	26.50	26.50	26.50	70.30	25.60	18.00	hmmbuild  -o /dev/null HMM SEED	110	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.90	0.72	-10.32	0.72	-3.89	3	76	2012-10-05 20:25:01	2012-10-05 21:25:01	1	1	76	0	2	35	0	91.60	92	74.39	NEW	MA-+uILsSLlusposEu+uACSto.aACsuA-hAELGLAhluuSc............................ScAuscuLVNLhRaRlDGALSE-YsCYLLo+G+ulsstLc+LsAKpLAucChpTFsclK+R.sht	......................hADKuILWALISASspEGRKACSLSYFuCKAAE.AELGLAYMAAND............................NKEFLTSLSNIMRYKIDAGLSESYTCYLLSKGKIIRPYLKNLNPLQLAADCIETVNKIKDKNKK...	0	1	2	2
+15457	PF15597	Imm36		Immunity protein 36	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved [DE]R motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox13 or Ntox40 families [1]. In some proteins this domain is fused to the Imm38 -like (PFAM:PF15599) immunity domain.	25.00	25.00	26.60	26.40	19.70	19.60	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.69	0.72	-10.22	0.72	-3.86	31	66	2012-10-05 20:00:33	2012-10-05 21:26:13	1	3	33	0	6	64	0	92.00	35	93.27	NEW	.slcp.Kp-l.ppIcchGY-SL+YslFs..Epp..pt.Wts+l.Ycs..sca.V.upcDRu.lsG+.hEFssFp-AKc+FlchL-hhVptN+htlcpGhss.YsSPLWD	.................phtp.+t.l.ptIp.hsapsL+.YslFp..cpp..ph.ats+l.hpp..spa.VYsTsDRuShs.GK..hpFpsFp-AhcpFlphLp.hVh.N+htlcpG.sspYssPLWp..........	0	3	3	6
+15458	PF15598	Imm37		Immunity protein 37	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved arginine. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox40 family [1].	25.00	25.00	30.30	29.60	22.00	23.90	hmmbuild  -o /dev/null HMM SEED	159	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.99	0.71	-10.76	0.71	-4.37	27	97	2012-10-05 20:27:06	2012-10-05 21:27:06	1	2	64	0	16	59	0	153.10	32	84.76	NEW	..tchhphsttuGhshssssss................hhhssssptthhlhppsut....ah.h.....sps-Rupttt.....hh...hssshsslc+allhhhusplRts..hpLPtlthPhs.pslssuaslpphs.t.........ht.lhsspssslshshsst.....hphssLSahhshshp-Lhs.ualc....ssG....tPLh	.....................................scl.sahphuGhshhtsscs...............hhhhspGucsthalpchsGh....ah.l......spo-Rhsccs....hph...uuuShsllEKYLhshaGsslRuc..+cLPsl...psPaps--lhPpaolsshshs........hss.LlsssGosluhssssp.......LlpLSHhLslolsslcc.SaLDs-G...pPLh.............	0	8	13	16
+15459	PF15599	Imm38		Immunity protein 38	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved E+G and ExxY motifs. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox40, Tox-CdiAC and Tox-ARC families [1]. The protein is also found in polyimmunity loci in polymorphic toxin systems.	25.80	25.80	25.80	26.80	25.40	25.30	hmmbuild  -o /dev/null HMM SEED	124	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.43	0.71	-4.59	30	130	2012-10-05 20:27:51	2012-10-05 21:27:51	1	2	118	0	19	109	1	116.40	27	77.94	NEW	.tclpsclhclut+lusss..ths.hhstp....t....hs-uts.lhhssst....Y+hhhhERGphhpccpTssh-ElLYWlhcslspshAhchthpptss.........c.pshR+lhascph..cLlsslssc...WupcttpchsthL	.....s.chpphh.chttchsh.p...phs.hhhtp.....t......stGp..h.hsppt....YhhhhhERGpt.schpTssh-EhhY.lhpclshh.huhcathc+tht.........c.pctR+ltFpKpl..pLhstlNss...Wtccstpphsthh.....................................	0	2	8	12
+15460	PF15600	Imm39		Immunity protein 39	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and a conserved DxEA motif and arginine residue. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-ColD family [1].	25.00	25.00	27.40	32.10	24.60	24.20	hmmbuild  -o /dev/null HMM SEED	187	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.19	0.71	-11.36	0.71	-4.43	8	16	2012-10-05 20:28:56	2012-10-05 21:28:56	1	1	16	0	4	13	0	175.80	43	95.36	NEW	MuSaIulG...........hVYc..s....csphpslIcha...l-LlusIssl.........Kh.s.hscsh-u-lhpshsl-chch.cssauplo.......cIpscllp.cslphhlRh.cEpcY.GlLhDIuE-cLltspSs-plE...pcLIsllhpIYpsssY-auFCDsEAEl-h..sPpslcPl.cssYullhhPc..Nsch+VhhssWcIDGlTpRpc+...	MuSalSsG...........CVYK.......puShKNllKhY...IDLluShANl.........-IENllChssEu-lppTcsLEElch.-ssFSplT.......cIsCK.lc.csl-hslRhhcEpsYpGVLFDlS.DaL.EhhSscpLE...NcLIsIlhsIYshhPY.FuFhDoEAEl-h..NPpslcPl.csPYAhLlhP+..Nsch+VYhssWcIDGlopRpc.......	0	2	4	4
+15461	PF15601	Imm42		Immunity protein 42	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold and conserved tyrosine and tryptophan residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-REase-10 family [1].	25.00	25.00	30.90	30.90	22.10	22.00	hmmbuild  -o /dev/null HMM SEED	134	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.63	0.71	-10.59	0.71	-4.74	33	74	2012-10-05 20:38:09	2012-10-05 21:38:09	1	1	69	0	17	69	1	125.60	35	92.37	NEW	VGhclshhha-lGpsshlauFFSTlshpLEpstWGo+aPhLhscL.YpGpLph-clppAhpELcpIcptLpphs.PspVl..WDh-sl.sppPPW.usplusslssLusYFhTscGcshh-lltcAl-pA.............hcpphclhIp	........VGhtlshhhaplGpsshlauFFSTlshplEsptWGo+aPlLMpcL.YpucLphcclppAlpELcpIpp.Lpphs.PspVl..WDh-cl.sppPPW.GssIssclssLusYFhTssGpshhcllhculppu.............hc.phsl.I.p.........	0	4	10	13
+15462	PF15602	Imm43		Immunity protein 43	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with a mostly alpha-helical fold and conserved arginine and phenylalanine residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Ntox48 family [1]. This domain is often fused to the Imm72 immunity domain.	27.20	27.20	29.70	29.20	25.30	19.60	hmmbuild  -o /dev/null HMM SEED	171	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.45	0.71	-11.10	0.71	-4.30	15	39	2012-10-05 20:41:16	2012-10-05 21:41:16	1	2	20	0	15	42	0	171.40	31	51.90	NEW	hss-hpRRplFaLLK+hoSaThWpRhh-hapsFAsshEcsl+phsts...-.stl.sschssILcsLA+hEcGlpcLp+G......................s+pla+hstshE.....huhsc.....t...pss......uaW.cth.phtshts.pls.sh.th.......hphsPhtsth.ppsltpLtssht.lssshhEstFh-.shP.ha	..s--hsRR+lFaLLp+hTSaohWcRth-hattFAstaEpsV+shPps........-.ptl.ssplstIhchLAth-cGlpcLt+G......................sRhVaphGpsh-.....huhcc.s.hsshhasps......saWccth.phtsh.s.pls.shsth.......hphuPhtst..ppshtpltshth.l.sstY-ptFhshshP.sa......................................................................................................................	0	0	0	6
+15463	PF15603	Imm45		Immunity protein 45	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein with an alpha+beta fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-ARC family. This domain is also found in heterogeneous polyimmunity loci [1].	25.00	25.00	29.20	28.20	23.80	22.50	hmmbuild  -o /dev/null HMM SEED	82	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.91	0.72	-9.59	0.72	-3.84	16	55	2012-10-05 20:41:55	2012-10-05 21:41:55	1	1	53	0	12	43	0	75.10	44	98.95	NEW	Mhlss.ssutlpl-lspGthhph.pGEhlhs.............spFllahsolppW-sPa-s..lotsEhppIlctlpcphscpshplsF-	........MKIoG.spStlpFDLENGallKA.pGEhLls.............GcFVVa+DSMcsWEPPaEscplopsElpcIIppVcppps-pTlplsF-....	0	6	8	9
+15464	PF15604	Toxin_43		Putative toxin 43	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a most all-alpha helical fold and a conserved HxxD motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion systems [1].
	25.00	25.00	27.70	27.00	24.50	22.80	hmmbuild  -o /dev/null HMM SEED	153	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.34	0.71	-11.16	0.71	-4.17	30	88	2012-10-05 20:43:07	2012-10-05 21:43:07	1	8	64	0	11	97	2	123.50	36	39.38	NEW	..sppcttEFcRQLcsQEcGLNcLTV-EalcNRptahsss...psp-sssspcARcc..hpcclc-phpppl....utp.....h..pAcppApcphpolAALHNPDhlAGGcsh......................IushGD+plNSSIGuQW+.......sRIssL-ptAccsspsh....ppssthNlKLp	.......................................t.p.tEFt+QLpsQppGhNch...TVcEalps.t.hhtts...........hthpsthtppstpc.....hppclpchhppth...ph.........tApptAtch......hps.AALHNPD.lAGGps.......................IsshGD+plNSSIGsQW+..............RlttlDtthpp.hscph....htsshhNl+L........................	0	3	6	8
+15465	PF15605	Toxin_52		Putative toxin 52	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all alpha-helical fold and conserved aspartate and glutamate residues, and K[DE] and[DN]HxxE motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5 or type 7 secretion system [1].
	25.00	25.00	27.70	27.40	20.90	20.20	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.59	0.72	-10.21	0.72	-4.14	8	23	2012-10-05 20:49:50	2012-10-05 21:49:50	1	7	23	0	4	26	0	91.40	45	7.60	NEW	stLosuQpssls+l-Nh.......IpsHLTDtDhoGThRDLsGsPV.PKss..GGYWDHlpEMpDoh+GLpNhp+sLcs....LsNPshsppstthhQutLscAspplcKIEshhcs.	.......stLsppQcuulc+IDNs.......IcstLpDpDl.GTL+DhsGpPV.PKps..GGYWDHhQEMpNoh+GL+NptcTLcs....lsNPp........hQutascAoctlsKIEshl+.u.	0	1	3	4
+15466	PF15606	Toxin_55		Putative toxin 55	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved lysine and cysteine residues, and GNxxD and WxCxH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1].
	25.00	25.00	28.40	27.60	20.90	17.20	hmmbuild  -o /dev/null HMM SEED	77	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.11	0.72	-9.49	0.72	-4.01	5	65	2012-10-05 20:50:46	2012-10-05 21:50:46	1	10	64	0	3	72	0	75.50	87	9.54	NEW	GhAlu...shMAuPGNQADTGIsccVs-lhs-thhsuGK+PDRC-VLQpLID....sGsIuAKs.AKuTQKAWGCRHSRHS+D+	.....GLALD..ITMIASRGNVADTGITDRVNDIINDRFWSDGKKPDRCDVLQELID....CGDISAKD.AKSTQKAWNCRHSRQSNDK.......	0	3	3	3
+15467	PF15607	Toxin_60		Putative toxin 60	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha-helical fold with conserved DxK, GNxxxG, and DxxxD motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6 or type 7 secretion system [1].
	25.00	25.00	32.20	29.50	24.60	23.40	hmmbuild  -o /dev/null HMM SEED	112	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-10.48	0.71	-4.04	62	137	2012-10-05 20:52:01	2012-10-05 21:52:01	1	12	114	0	26	125	1	105.80	30	31.36	NEW	shhhahppVpssusWDaK.pht.th............................h....tth.hhh-sauNhHYGalGpAh..GhspshLhpuAGhsQhhssstp......................................shhDDssDphsIphGlchapp.	..........................................................shahttVpssusWDaK.pht.th...........................hhhp..tphthhaDsauNlHYGYVGhuh..Ghs-shLLtuAuhtQhhsstt.......................................shhDs.sDptsIphGhphapp.p....	0	10	18	24
+15468	PF15608	PELOTA_1		PELOTA RNA binding domain	Anantharaman V	la_psag	Anantharaman V	Domain	This RNA binding Pelota domain [1] is at the C terminus of a PRTase family [2]. These PRTase+Pelota genes are found in the biosynthetic  operon associated with the Ter stress response operon and are  predicted to be involved  in the biosynthesis of a ribo-nucleoside  involved in stress response [2]. 	25.00	25.00	25.10	47.60	23.60	23.20	hmmbuild  -o /dev/null HMM SEED	102	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.56	0.72	-10.34	0.72	-4.24	65	343	2012-10-10 14:40:03	2012-10-06 20:01:06	1	7	333	0	72	266	2	102.60	39	24.86	NEW	psps.sp..ht.hhs..spps..phpuh.pslcpltpcasIsslNhlKPGlGEsTRVLLRRVP.+lLl+.stss....s-lsHlhhLAcc+GVs..Vcphs..sh..sYsslulI+slt	............................tsh......hth.hpsspshphpuhpslppl.uccapIsslNhIKPGluEsTRslLRRVP.+lLVR.sh..ss....PDlshllhLAc-KGlsVcEhs.sh..tYpslslIKplh...........	0	20	44	60
+15469	PF15609	PRTase_2		Phosphoribosyl transferase	Anantharaman V	la_psag	Anantharaman V	Family	This PRTase family, with C terminal TRSP domain, are related to  OPRTases [1], and are predicted to use Orotate as substrate. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	35.20	35.20	39.00	40.70	31.40	30.70	hmmbuild  -o /dev/null HMM SEED	191	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.12	0.71	-11.26	0.71	-5.00	67	330	2012-10-10 14:25:38	2012-10-06 21:18:51	1	4	322	0	70	261	4	196.20	43	44.89	NEW	slscL.....hshAtR.+NPKRuFLFVS+VLGKHlPlsPsshhsshppLApthstpl...........................................................................sts................slhIGhAETATuLGpuVacsh..p.s..tp.........YLHoTR+s.lss.....p..hspFcEpHSHAosHlla.sss.shhps....su...s.LVLVDDEhoTGpThlNllpuLppt..hP...h.cchllsoLlDW............ps.t..ssltpcls.l.....lssVSLlpGph	..............................s.lcsLhslAtR.R.NPKRAFLFVS+VLG+HlPlpPushhpshppLApphss.sL...............................................................sss.............lLhIGhAETAsGLGtuVacplptpp......hYLpSTR+slsu.....shhspFcE-HSHATsHLlYhsss....th.hpp.....uc.slVLlDDEhTTGsThlNllpAL+sp..hs...hcphlssoLsDW........pt.......sslscch.s.l..lssVSLlpGp.........................	0	20	44	60
+15470	PF15610	PRTase_3		PRTase ComF-like	Anantharaman V	la_psag	Anantharaman V	Family	This PRTase family is related to the ComF PRTases [1]. These genes are found in the smaller biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	110.50	110.50	192.20	191.90	29.10	28.50	hmmbuild  -o /dev/null HMM SEED	274	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.92	0.70	-11.79	0.70	-5.48	17	23	2012-10-10 14:25:38	2012-10-06 21:57:01	1	1	23	0	9	24	0	273.30	30	91.63	NEW	Mhs.thSLHpItsss..phsFssssYSRaKaGDsphAcpFGppLhcuFIsp...........htstphps-plVhlsSsapplPTAopsLppaFlppLNpaLhppstpsslpsKlhRsto.hp..DYusLshE-R.pl.ts-saaIDpphl...pG+sllFlDDI+lTG.S+Ectlhp.hpphtlcs...chhaLhhs-..ppsh..csslEspLN.hsVcohpD..ltplhpussFphNpRhVKalLsts.s-.ashFlp..p.scshhppLhchAluNsYH.p.ppYpsNlphLt..l.....shtuh.................	......h...thuLapIhsss..phsFssssYSRaKaGDsphActaucpLhcsFlsp...........apsthhps-plVhlsSsapslPTAossLppaFVccLNpaLscput.sslpsKlhRhto.sp..DYusLshE-R.pl.tsssaaIDp-hl...sG+plIFlDDl+lTG.S+EcpVhp.htphslcu...chhalhhs-..spsh..csslEs+LN.hsVcshhD..ltpllsussFphspRhlKalLutsppc.hssFlp..phssshhppLachAluNpYa.p.ppYtsNLshLp..l......h.......	0	3	5	7
+15471	PF15611	EH_Signature		EH_Signature domain	Anantharaman V	la_psag	Anantharaman V	Domain	This domain with a strongly conserved glutamate at the N-terminus  and a histidine at the C-terminus [1], is found in a SWI2/SNF2 four gene operon [1]. Its strict-neighborhood association with\	\	    SWI2/SNF2 ATPase strongly suggests a function in conjunction with it [1]. The other genes in the operon are a OmpA protein and a TM protein [1]. This has a DNA related function along with the TerY-P triad [1].	25.00	25.00	41.50	40.40	23.20	23.10	hmmbuild  -o /dev/null HMM SEED	389	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.55	0.70	-12.60	0.70	-5.41	79	135	2012-10-09 15:52:58	2012-10-06 22:16:26	1	1	129	0	40	115	7	383.70	22	79.64	NEW	h.phshcplhstlppht...hstplps..........phhhhshs..h.h.....p...th.t..sp.........t.hhshlhp.........ht...ph..pptshtsLhpsYhstas............pthtshh..........lttph...thppt..........hhphhpphp....tlhsspss.th.lspphhp..st.ts.hptl..t....phslss....ssahtpshhthhlpphtphp....spthl.............ccl.ph.h...lh....ps......hhphtsphhpthLphah.p..pt..t..pphcpt.lpphl....ls...hhG-Ppltss..p......Wtt........lsc........pstphlptWLscp...slchFFpllp..t.st................h.ptRtpFWhpahcp..lspshlhhuss..Ahp.hppthtt...tth.s.phu.php........p.s..spsshlhpl...s....sh.hhVE............asssupshhhap.ps...ph...........s..pthp....h.....thstpl.....+pts..........sh.t................ph....sH.ps...............sWpt+hpphL	................................................................................................................................ht....shtplhstltphp...htp.lss..........plhhhslsh.h.tt.tp..tph....sc....plhstlhc.........hhpp.pphshpuhhptahspas..s...t.cshtsah..........lttph..pspcp.............ph.p....pllsssus.phlucphhp..sp..hsh.chl..t....phtlpp...tupahstshhhhhlcplspls.....-cshl..............-cl.ch.h..lh..cu.........phctpshlhptlLphhh..t..ps...s..sphpcshhphl....Ls...hhGDP+lsssssp....Wpp.........lp.............shhphlhsWLsch...DLchFhchlpths.t.............thh.sRcpFhpthhct..lsps+lhLu.c..Atphhpppht....cph.spauplp......csspuhlhhph.s....sh.hhVE...........a.csu.ssh.asYp.hs.p..............s.pphp..h.....shssph...........pchs.p.....sht...............+lsHss...........uWppKhht.................	0	10	19	29
+15472	PF15612	WHIM1		WSTF, HB1, Itc1p, MBD9 motif 1	Iyer LM, Aravind L	la_psag	Manual	Family	A conserved alpha helical motif that along with the WHIM2 and  WHIM3 motifs, and the DDT domain comprise an alpha helical module  found in diverse eukaryotic chromatin proteins [1].Based on the  Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins [1][2].  The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes [2]. The conserved basic  residue in WHIM1 is involved in packing with the DDT motif. The  module shows a great domain architectural diversity and is often  combined with other modified histone peptide recognizing and  DNA binding domains, some of which discriminate methylated DNA [1].   	16.70	16.70	16.70	16.70	16.60	16.60	hmmbuild  -o /dev/null HMM SEED	50	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-8.02	0.73	-8.48	0.73	-3.75	36	528	2012-10-09 18:07:10	2012-10-07 01:56:28	1	70	195	2	305	505	1	49.50	21	3.66	NEW	pptshspthpptsa.............hplsspp+lplLphLschh...hsssshpshlppptctt	.....................................h....hh.thpppsa.............hplssppKlplLphLscph...lsottl+shlppp....h........................	7	53	121	197
+15473	PF15613	WHIM2		WSTF, HB1, Itc1p, MBD9 motif 2	Iyer LM, Aravind L	la_psag	Manual	Family	A conserved alpha helical motif that along with the WHIM1 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [1]. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins [1][2]. The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes [2]. The acidic residue from the GxD signature of WHIM2 is a major determinant of the  interaction between the ISWI and WHIM motifs. The N-terminal portion of the WHIM2 motif also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA [1].	21.00	21.00	21.00	21.00	20.90	20.90	hmmbuild  -o /dev/null HMM SEED	38	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.73	-7.77	0.73	-7.97	0.73	-3.82	15	298	2012-10-09 15:57:33	2012-10-07 05:24:23	1	45	177	0	195	286	0	41.60	35	3.52	NEW	RppsLGhDRpts+Yahh........................tsspslhltcp.s	...RtpPLGpDR.tNRYWaF.....................................s.....t..tpsthahp.........................................................	0	38	95	146
+15474	PF15614	WHIM3		WSTF, HB1, Itc1p, MBD9 motif 3	Iyer LM, Aravind L	la_psag	Manual	Family	A conserved alpha helical motif that along with the WHIM1 and WHIM2 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [1]. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal  linker DNA and the SLIDE domain of ISWI proteins [1][2]. The resulting complex forms a protein ruler that measures out the  spacing between two adjacent nucleosomes [2]. WHIM3 along with  WHIM2-N constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA. The module shows a great domain  architectural diversity and is often combined with other modified  histone peptide recognizing and DNA binding domains, some of which  discriminate methylated DNA [1].	18.10	18.10	18.10	18.10	18.00	18.00	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.86	0.72	-8.32	0.72	-4.18	35	259	2012-10-09 17:50:33	2012-10-07 06:11:50	1	43	130	0	154	252	0	77.50	32	6.14	NEW	WthhpstcplcpLh..csL.................................................................................................................................................................................sscGhR...EppLpppLtphh....pplpssh	.....................................................................................................................................................................Wthhscscpl-pLl...puL..............................................................................................................................................................................................pPpGhREtpL+ccLpp............................................................	2	27	51	96
+15475	PF15615	TerB-C		TerB-C domain	Anantharaman V	la_psag	Anantharaman V	Domain	TerB-C occurs C terminal of TerB in TerB-N containing proteins. This domain displays multiple conserved acidic residues (TerBC) [1]. The  presence of conserved acidic residues in both TerB-N and TerB-C  suggests that they, like the TerB domain, might also chelate metals. These two domains might also occur together in the same protein independently of TerB [1].	26.30	26.30	27.20	27.40	25.40	24.70	hmmbuild  -o /dev/null HMM SEED	144	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.87	0.71	-11.01	0.71	-3.94	140	224	2012-10-09 17:52:00	2012-10-07 20:41:01	1	11	214	0	64	226	6	149.20	21	22.62	NEW	slcshts........................tpptst.ss...................lplDhsclsplcp-sspspthlss...........lhs--c............tp.........................................-.t...p......................ht.p..p...ts..............pssss.......................................................G..L-s.......sctphLchL..........lsc.pp..W.ctchpphstph.............pLhhsssl-pIN-hsa-ths-sllE...s..s-shtlst...-hhccLp	..................................................................................................................................................s........................p.......hplDhsplstlcp-sppsp....ss...........lhs--p.....t...............................................p..p..................t.t.ps....s........t.tss..........................................................h.u.Lsp.......schphLchL.....lsc.ps.a.htphpphspsh.............plh.lsshl-pIN-tha-hhsssll-...s..s-shtlsp-htpcL........	0	21	41	52
+15476	PF15616	TerY-C		TerY-C metal binding domain	Anantharaman V	la_psag	Anantharaman V	Domain	TerY-C is found C terminal to TerY-like vWA domains in some proteins [1]. It has 8 conserved metal chelating cysteines or  histidines [1]. It occasionaly occurs as solos [1].	28.40	28.40	29.30	75.20	27.60	27.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.25	0.71	-11.31	0.71	-4.22	48	97	2012-10-09 18:02:15	2012-10-07 22:23:15	1	2	92	0	17	68	6	127.90	48	40.28	NEW	ssshD-shVllsG+C....s+T++PYLhKYER......t..sh.t....h.plphpta..p...lsGsaPlD.csYhsa.SDspssstplNTo-LhGs..PGCPaCGNthuaAhC..s.CG+lhC.l.sG.sc......pssCPWCsp.sssau.sss....ss.FDlsRGcG	..spAaDENCVTLsGRC....SKTRRPYLhKYERP....sspl.ouLs....F.pLNlsuF..NluGCYPID.EDYFuWS.Dtosou.QVNTS-LhGs..PGCPaCGNtsAFAhC.s.CGKLhClsG.sc......cVhCPWCtpshsausss...tssFDlsRGRG.....	0	5	11	14
+15477	PF15617	C-C_Bond_Lyase		C-C_Bond_Lyase of the TIM-Barrel fold	Anantharaman V	la_psag	Anantharaman V	Family	This family of TIM-Barrel fold C-C bond lyase is related to Citrate -lyase. These genes are found in the biosynthetic operon, with other  enzymatic domains, associated with the Ter  stress response operon  and are predicted to  be involved in the biosynthesis of a ribo- nucleoside involved in stress response [1].	217.60	217.60	221.30	220.40	214.70	214.10	hmmbuild  -o /dev/null HMM SEED	346	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.38	0.70	-12.11	0.70	-5.63	70	344	2012-10-10 15:06:27	2012-10-07 23:05:45	1	2	337	0	72	251	6	324.30	42	93.39	NEW	phhsauLGATLYhPATRpclAcslhcp+hsGlpSlVlCLEDAlu-p-VshA.pNLhphLppLsst............................ptsshPLlFlRsRssc.hppLssth......slphlsGFVlPKF...............stpshpsah-hltp..ss...............LhhMPsLEo.-lh....csppLtpltphLspa..+-plLAlRIGusDLhulhGlRRs+chTIYD.ssluslIsslVslFutt....uaslouPVaEaa.ss.p..............................................sLhRElsLDhANGLlGKTsIHPSplssVpuhhhVopE-apDAhcILs.s.s.p......uVhKSs..spMsEstsHppWApclLtRAclaGV.hscstshsphh	.......c..sasLGATLYhPATRpcIA-sllcp.Kh.....s.GlpSlVlCLEDAlu-s-lshA.pNLhphLppLusthtt.........................stsshPLlFlRsRpsp.hptLhsch..............slptlsGFVLPKF...............T.sshssah-hhsssp...............LhhMPsLEot-lh....cstphtpluptLcpa..+-RIlALRIGusDLhulhulRRs+chTlYD.sshu.lIt.lVsVFu.t....sFslTuPVaEahsspp...........................................sLh+ElsLDhApGLlGKTsIHPuQIpllpshhhVopc-asDAhcILss..sp......uVhKSp..stMsEstsH+pWAppILpRAchYGlhs-pss.....h........	0	23	45	62
+15479	PF15619	Lebercilin		Ciliary protein causing Leber congenital amaurosis disease	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:O95447	Family	Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localised at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia.  Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.	26.00	26.00	26.00	26.00	25.50	25.40	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.94	0.71	-11.35	0.71	-4.88	31	158	2012-10-08 11:36:17	2012-10-08 12:36:17	1	4	81	0	93	142	1	180.10	39	32.43	NEW	hls+RlLSARLhKIp.ELcN-ls-lph+L--ltpEN+hLKpLQhRQcKALs+aEsopsElPQLlspHpsEl+sLRccLRKoQE+ERshc++L+-s-scLh+s+ssLp+Lp+Lu-D+pLsER-ELsc+Lsthps+hpps-++IppLEKpLcLsspuFpRQLtsEp+KstpApppsctLppElppLppKLKEKEREL	..............h.hs+RlLSARLhKIp.cLpN-ls-lph+LpplhpENchLKpLQhR.ppKAL..sKaEsspsclsQLl.t+HpsEl+sL+ppLRKSQEcERssp++l+-s-s-Lh...+.......s+ssLp.......c....LpcL.u-s+pLsE.R..--L...sc+Lsthpt+h-ss-++Ipp.........Lp+...pLcLsspsapRQLhsEp+KshpspppschLphElppLppKLKEK-+pL...............................	0	25	30	57
+15480	PF15620	CENP-C_mid		Centromere assembly component CENP-C middle DNMT3B-binding region	Coggill P	pcc	Pfam-B_64009 (release 26.0)	Family	CENP-C is a component of the centromere assembly complex in eukaryotes. CENP-C recruits the DNA methyltransferases DNMT3B, in order to establish the necessary epigenetic DNA-methylation essential for maintenance of chromatin structure and genomic stability.  This middle region of CENP-C is the binding-domain for DNMT3B. Binding of CENP-C and DNMT3B to DNA occurs at both centromeric and peri-centromeric satellite repeats.  CENP-C and DNMT3B regulate the histone code in these regions [1,2].	27.00	27.00	183.80	183.80	25.00	25.00	hmmbuild  -o /dev/null HMM SEED	260	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.26	0.70	-11.95	0.70	-4.67	13	40	2012-10-08 12:56:00	2012-10-08 13:56:00	1	5	23	0	16	32	0	248.70	59	31.10	NEW	hKL.LEDEFIIDESDpSFASQSWITIPRK.ussLKQpoVsPsESTAlLQuKKSREKHH........slSPpTLTSDKHScKA+PVEKSQPScp++LupSCsLosEhENssRSTKpEhaSENAcKsSGsKRTlcQK.Q++KhKsNlsEEplchtQSK-cNlNh..SHIsQDKLQRNSDRNMc-sEEhpNsslSKKQhPsV.GsKKpoo......ppKK-K.cuKKK+FSstSpKNKlVP-EVT.TlTRSRRISRRPSsWWVVKSEpSsl.SN.oSlRNELsV	....hKLlEDEFIIDESDpSFASpSWITIPRK.uGsLKQ+slS.PAESTAlLQu+KSREKHH........sl.PpTLsssKHScKsHPVEpSQPS-cphLssShALosEhENshRSTKaEMaScNAcKsSusKRTIKQK.QRRKaKApsuEEQLDhGQSKDENIph..SHIsQDKhQRNSDRNMEEpEEhtN-sl.SKKQMPPV.GSKKsSs........+KDKtEuKKK+FSsES.KNKLVPEEVTSTVTRSRRISRRPS-WWVVKSEESsV.SN.SS.lRNELsl...	0	1	1	1
+15481	PF15621	PROL5-SMR		Proline-rich submaxillary gland androgen-regulated family	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:P02814	Family	SMR is a family of proteins found in eukaryotes. The family of SMR proteins is expressed in the submaxillary gland. SMR members may play a role in protection or detoxification.	24.90	24.90	25.00	24.90	23.10	21.50	hmmbuild  -o /dev/null HMM SEED	113	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.10	0.71	-10.82	0.71	-3.64	16	60	2012-10-08 13:28:38	2012-10-08 14:28:38	1	1	16	0	13	58	0	99.30	40	68.32	NEW	MKsLsLlhGLWsLhuCFpsuEspRGPRt.asPt.......ssPPs..PatsthhPsPsPPsaGsGhssP.P.......husGhh.Pss..............s.htsh.......l.ssss.P..sPuhP	.MKsLshlLGLhALhuCFpsuESpRGPRtPYsPG........sPP...PatPtaVPPPsPPPaGsuphsP.s.......assshh.Pss....s.s..........s..................................................................................................................	0	3	3	3
+15482	PF15622	CENP_C_N		Kinetochore assembly subunit CENP-C N-terminal	Coggill P	pcc	Pfam-B_21609 (release 26.0)	Family	CENP-C is a vertebrate family that forms a core component of the centromeric chromatin. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].	27.00	27.00	126.40	104.90	17.80	17.30	hmmbuild  -o /dev/null HMM SEED	286	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.20	0.70	-11.74	0.70	-5.16	10	50	2012-10-08 13:43:13	2012-10-08 14:43:13	1	6	23	0	19	35	0	223.80	58	35.09	NEW	DHLKNsYRRRFCRPS.RAPsINTEQGQNlLEILQDCFEEKShANDFSsNSTKSVlhSTPKlKDhClQSPSKE..CQKSHP....KSlPVSSRKKEusLQhhlEPSEAusRSVQAaEVHQKILATDVuSKNTPD.+KhSS+KhcD+HuEuDEEFYLSVGSPSVLLDAKsSsSQNAlPSsAQKRETaoScNSlNhLSSSTEIShKT+KRLNFEDKslLKKlEIEscVSclEDKlSEt.QE+KsScTSQKRlQDoEhEIQPQAKKSFSTLFLETVKRKSESSsVVRHsATsPPHsSP	...........DHLKNtYRRRFCRPS.RA.sINTcQGQNlLEILQDCFEEpShAssFSsNuTcSl..ST..KhKD.plQSsSKE..sQcSHs....KSlPVSS++KEusLQh.....sEP....sEssscSVQAHEV+Q+hlusD.VtS+sTss.p+hSS..+ph.pshcs-AsEEFYLSVGSPsVLLD.AKsS..s.QpslsSsAQKRETYT.cNSVNhhsSST-lShKT+KRLNFEDKshL+phEItNpVSc.EDKhSEt.QE++sStoSQpRhpDoE.EIQ.puKKSFSoLFLETVKRKScSSslVRHhAssPsp.sP.............	0	1	1	1
+15483	PF15623	CT47		Cancer/testis gene family 47	Eberhardt RY, Coggill P, Hetherington K	pcc	Jackhmmer:P0C2W7	Family	CT47 is a family of proteins found in eukaryotes. Proteins in this family are typically between 262 and 291 amino acids in length. There is a conserved HIL sequence motif. The function of this family is not known.	27.00	27.00	149.70	149.60	22.50	22.40	hmmbuild  -o /dev/null HMM SEED	279	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.88	0.70	-11.89	0.70	-4.66	14	37	2012-10-08 14:01:00	2012-10-08 15:01:00	1	1	15	0	12	35	0	262.80	50	96.59	NEW	MSsTGDtDPspssQEuPso.tGuQuttutAt-uhutDSuPssG-.....ssPtscsuGlsGP.tG.pEt....EG............GsAEEDSDItss.........E-tptpppstuhshhVsA++FPMsGFRhhFLDLVHShLpRlYaNDHILIcspp.shlhht.ptst.............up.tpstlhhhsphhssussshEGpu.sLh....p.ht.hP..EPs..u-.sE.ApE.........tcssEEusthEsApctscE.....................u.E.tspEsstPE..........chsctQsEc.cEEAQsstu-tcccp.pccppc	..MSATGDtcPsQsDQEAPVSQEGAQAEAutAGstEGuDSGPcSuD.....hVPsAEssGVAGPhcGLuEE.....EGEQt.....tuLAAsPhsGuAEEDSDItss....E....EEEEEtppAsNhDlsssuRRYPhsGhRhhFLDhVHSLL+RlYHNDHILItsRp.uRLMhts+sus............Ps.h.spsslLLlspRLGsGAsuhEGcuLGLl......pEAAoVP..EPsVPA-.AEhApEPt..............EEuAEEt.sEEsAE-.spEc...........u...........uEEPs.....spEAsAPE..........ElTK.Q.EKW-EEAQsusuEEcK-ptpcKstc........	0	2	2	3
+15484	PF15624	Mif2_N		Kinetochore CENP-C fungal homologue, Mif2, N-terminal	Coggill P	pcc	PB002175 (release 26.0)	Family	Mif2_N is a family of fungal proteins homologous to mammalian CENP-C. On depletion of CENP-C proper formation of both centromeres and kinetochores is prevented. The N-terminal of CENP-C is necessary for recruitment of some but not all components of the Mis12 complex of the kinetochore [1,2].	23.50	23.50	24.00	24.00	22.90	22.90	hmmbuild  -o /dev/null HMM SEED	136	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.18	0.71	-10.99	0.71	-3.57	44	123	2012-10-08 14:07:44	2012-10-08 15:07:44	1	7	115	0	94	122	0	132.60	24	21.73	NEW	cahslGhpuR..........KTGlslc-pGpRDEaGMEslDshFSSP-c..oslp.........................ttt.ppuSp..sMchsss.ssssPsshlss.........tpp.th.sPpu.poP...........t...h....p.tht...toSshppsstpss...................ts.hppch-..h	................................phhplGhtuR..........KTGlsl+cpsp+DEaGMEsl-shFuus-c.ushp........................................p...tp..ssptsSp....shshsss.stssPsshlps.........tpp.hh.s..Pps..pos.............ht...s.ht..us....spR.........s..ht.........pSsh.p....tt..............................................................................................................	0	20	50	80
+15485	PF15625	CC2D2AN-C2		CC2D2A N-terminal C2 domain	Zhang D, Aravind L;	la_psag	Mannual collection	Family	Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition\	zone of cilia [1]. This is the first C2 domain of ciliary CC2D2A  proteins which also have another C2 domain (CC2D2AC-C2) and  a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).	25.00	25.00	26.80	25.90	24.60	24.00	hmmbuild  -o /dev/null HMM SEED	169	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.83	0.71	-10.47	0.71	-4.78	20	138	2012-10-10 12:23:49	2012-10-08 22:33:14	1	4	88	0	84	110	0	160.10	33	11.78	NEW	tPG-sphhspLsssssls......ssspsPpsEtsRRpphpphphalplhlNs.......ppVspopsp.L...tssFssphscthplpl.p+.hPcslplplaEsss...htsphlupVhlPlPsstssh.hs...............tspphpFoocp.hp.sh.h.s....................ppssphhsGslhhsssWsptpstt.s	.............................PtEshlhs.Lshssslo......ssptssp.sEh....RR.pclp+pphalKlhaNs.......KcV.u.pTps+sL..ssDF+lpFsplFsl........pl.hp.hPESlsLplaEsss...sssslLApV.alPlPpsosspups.............................shcphEFSSsptlthsapusGu.............hpsssssphhh...hTSGplshssuWuhscss..l......................................................	0	31	39	59
+15486	PF15626	mono-CXXC		single CXXC unit	Iyer LM, Aravind L	la_psag	Manual	Family	This is a solo version of the zf-CXXC domain with a conserved  CXXCXXCX(n)C, zinc-binding motif. This is, thus far,  only detected  in the plant lineage in diverse chromatin proteins [1].  Structural  comparisons show that the mono-CXXC is homologous to the structural- zinc binding domain of medium chain dehydrogenases [1]. The regular  zf-CXXC domain binds nonmethyl-CpG dinucleotides.	20.00	10.00	23.30	13.20	18.10	9.90	hmmbuild  -o /dev/null HMM SEED	46	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.80	0.72	-8.49	0.72	-4.02	7	7	2012-10-09 00:30:47	2012-10-09 01:30:47	1	4	4	0	7	8	0	44.10	22	4.97	NEW	cssuC.hCpsCtt.s.ssps.s.ttt.tsp...............tsspsspClplcsh	cssuC.hCpsCtt.s.ssps.s.ttt.tsp...............tsspsspClplcs..	0	4	6	7
+15487	PF15627	CEP76-C2		CEP76 C2 domain	Zhang D, Aravind L;	la_psag	Mannual collection.	Family	Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia [1]. This is the new C2 domain that is contained by ciliary  CEP76  proteins [1].	47.00	47.00	47.60	81.10	40.00	46.50	hmmbuild  -o /dev/null HMM SEED	157	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.09	0.71	-10.73	0.71	-4.72	16	82	2012-10-10 12:23:49	2012-10-09 01:37:56	1	2	63	0	49	79	0	157.60	51	25.06	NEW	hsphssscphLalclhsG+AFl-als.......................ssssophplplpatsQRFsSpsVssssEPsFsEpFLhcLcppshtts...............htsllslspPl+llllpsc.stpp..............pLlusphl-WRplLppss.............shslELtGhsspt.phssGlLplplELlPshpshh	...........p..plDPsRRYLYLpVLGGKAFLEHLp-s-s.................LsGQssSTFTLsLHFRs.QRFRS+PVP.CACEPDFcDGFLLEl++-uhGcusch..........................ssuTTMLSIuDPlHhVLIKTDhhGET..............TLVuSaFLEWRoVLuSpsGhs..........sLoVELhGVG...sEu.KVsVGILsl+LEhaPsLspsL...	0	18	23	34
+15488	PF15628	RRM_DME		RRM in Demeter	Iyer LM, Aravind L	la_psag	Manual	Family	This is a predicted RRM-fold domain present at the C-terminus of  Demeter-like glycoslyases [1]. These proteins  are involved in  DNA demethylation in plants where they catalyze removal of the 5mC  base and subsequently cleave the backbone through lyase activity.  Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic  domain with ssDNA or regulatory RNA [1].	34.60	34.60	34.60	35.00	18.20	34.50	hmmbuild  -o /dev/null HMM SEED	104	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.40	0.72	-4.34	21	84	2012-10-09 00:46:22	2012-10-09 01:46:22	1	10	25	0	52	90	0	95.50	62	7.39	NEW	GTlLIPCRTAMRGSFPLNGTYFQVNEVFADHpSShNPIsVPRshIWsLsRRhVYFGTSVsSIF+GLosEcIQtCFW+GaVCVRGFDRcoRu............P+P...LhARLHhsso	............GTlLIPCRTAMRGSFPLNGTYFQVNEVFADHsSShNPIsVPRphlWsL.RR..hVYFGTSlsoIFKGLosc-IQpCFW+GaVCVRGFDppoRu............P+PLhs+LHhsss................................	0	10	30	41
+15489	PF15629	Perm-CXXC		Permuted single zf-CXXC unit 	Iyer LM, Aravind L	la_psag	Manual	Family	This is a permuted version of a single unit of the zf-CXXC domain  that is detected in the Demeter-like proteins of land plants.  Structural comparisons show that the mono-CXXC is homologous to  the structural-zinc binding domain of medium chain dehydrogenases  [1]. The classical zf-CXXC domain binds nonmethyl-CpG dinucleotides.	21.30	21.30	21.30	21.30	20.90	21.20	hmmbuild  -o /dev/null HMM SEED	32	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-7.37	0.72	-7.79	0.72	-3.95	10	47	2012-10-09 00:22:00	2012-10-09 02:18:17	1	4	17	0	28	56	0	31.40	54	2.09	NEW	PcppCsS.pEoG+LCs-pTCFSCNSlREspSQT	...PcppCsS.pEsG+LCsppTCFSCNSlREspoQh...	0	4	17	23
+15490	PF15630	CENP-S		Kinetochore component CENP-S	Coggill P	pcc	manual	Family	CENP-S is a family of vertebral and fungal kinetochore component proteins. CENP-S complexes with CENP-X to form a stable CENP-T-W-S-X heterotetramer.	28.00	28.00	28.00	28.00	27.90	27.90	hmmbuild  -o /dev/null HMM SEED	76	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.57	0.72	-3.80	46	231	2012-10-10 12:36:46	2012-10-09 13:40:56	1	9	190	12	158	473	3	72.70	38	43.37	NEW	p+LKuAlaasVGc.ls-E..p.sh....cpshs...so.phl......uALoEllapQ....lp.sl.upDLEsFA+HAtRoT.Iss-DVhLluR+Ns...sL	...........................pcLKuAlahsluplsc-.....s............ctshp........ho.phI......uAlsElsapQ.....................hc.sh.upDLEhFA..............+........HA.tRsT.lss-DVhLlARRsssL...........	0	47	84	126
+15491	PF15631	Imm-NTF2-2		NTF2 fold immunity protein	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein of the NTF2 fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-NucA family [1]. This domain is also fused to ankyrin repeats and the PFAM:PF14025.	26.00	26.00	26.00	32.10	25.90	23.80	hmmbuild  -o /dev/null HMM SEED	66	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.38	0.72	-9.32	0.72	-3.99	17	170	2012-10-09 13:50:12	2012-10-09 14:50:12	1	1	121	0	11	48	1	67.30	70	58.81	NEW	sAlclAEhhlh.lYGppl..ppKPahlshpssp..WllpGoh........ssp........hhGGshhIhIpKpDG+lLplhHsK	...AlpLAEIYV+.RYGpch.AEEEKPY.ITELssS..WVVEGsh.......hs.p.........lAGGVFIIEIsKpsGplLNFhHuK...	0	10	10	11
+15492	PF15632	ATPgrasp_Ter		ATP-grasp in the biosynthetic pathway with Ter operon	Anantharaman V	rdf	Anantharaman V	Family	This ATP-grasp family is related to carbamoyl phosphate synthetase. These genes are found in the biosynthetic operon associated with the Ter  stress response operon and are predicted to  be involved in the biosynthesis of a ribo-nucleoside involved in stress response [1]. In press. Mol. BioSyst. 2012, DOI:10.1039/C2MB25239B. "Ter-dependent stress response systems: novel pathways related to  metal sensing, production of a nucleoside-like metabolite, and  DNA-processing" Anantharaman V, Iyer LM, Aravind L;	182.70	182.70	192.60	190.40	175.00	167.50	hmmbuild  -o /dev/null HMM SEED	330	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.99	0.70	-11.94	0.70	-5.69	99	206	2012-10-10 13:17:03	2012-10-09 14:55:16	1	1	201	0	43	148	9	327.20	42	96.59	NEW	hlWFhcGhSupppllpul+s..s.................................tslplhASHpppcstlhthADhuhh..EPp....sspc...............hlpalLchscppslclllsu+psph..httpRspFput.....GscLhs.ssshpslphh--Kspahtthcp.....t.Gl...sssssht.lsos-EL.psuh.ss....lth...s......sp.lClKPssGlhG.hGFhhlcp........sssshc.shtp...ssspp.lshpthlsuhpts....-ph.....shllMPYLsGsEhSVDhls.cp................Gc...llAAV.sR.+Ks.....G..hh.Qplppcsph.hplApchActhshcGlhNlQhRpc.ssGp.Ph.LLEINsR.SGGlshot.ts....GVNLPtlhs.thtLGhht..-....h............h....psh.pVpslosslth.s	...........pIWFhcGhSSpR-lIpul+shs.............................pshulplaASH+sp+spILphADhuhh..EPp.....Dspc.................hlpalhchspsasIchIhsGRssph..hEpHRuth-st.....GspLsTGusssshlslsD-Kspasphhcp.....pGL.PVlPohp.VsohsEL+stlus.....sas......sp.lClKPVoGIYG.hGFW+hDc........osushssFs+...s-pRhVosppYlsAhptu....EshpPhlLMPYLPGPEaSVDhLs-+................GcllAAVuRRKp......G..slQhLh.p-usAhELApcsAchhpsDGLVNVQTRsD.ssGp.PlLLEhNhRPSGGlsYTh.co....GVNLPGLFA.thpLGLhsp-h..sh......h.pslsVRulTssl.h.p....................	0	13	28	36
+15493	PF15633	Tox-ART-HYD1		HYD1 signature containing ADP-ribosyltransferase	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and aspartate residues that comprise the active site. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, or type 7 secretion system [1].	25.00	25.00	45.30	43.40	23.00	22.20	hmmbuild  -o /dev/null HMM SEED	96	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.70	0.72	-10.31	0.72	-3.18	18	25	2012-10-09 14:47:52	2012-10-09 15:47:52	1	12	21	0	9	25	0	97.30	27	14.38	NEW	lYHYTsccGhsuIh-Sshlp.....hpu.s.hp.thssGpYhoshuPGp......hp.ucuht+hsh.sss+ss+.al..ElDsss..Lphlcs..pcsshh.h.psslDlssct	.....laHYTsccGhpuIhcosplp.....hpupsshp.utssGtYloshuPsc.....................hphucuhtphsl.sssKsoH.aI..ElDsss..Lphlcs........pcsshhhh..ptslDlssp...............	0	4	8	9
+15494	PF15634	Tox-ART-HYE1		HYE1 signature containing ADP-ribosyltransferase	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteristic histidine, tyrosine and glutamate residues that comprise the active site [1].	25.00	25.00	530.80	530.50	22.00	21.30	hmmbuild  -o /dev/null HMM SEED	285	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-10.84	0.70	-11.96	0.70	-5.44	2	8	2012-10-09 14:52:20	2012-10-09 15:52:20	1	1	8	0	1	2	0	284.60	86	32.52	NEW	GLsL.pMlRNss.TLps....tPpKsEDGYYYHlopupNL.ShlppGFhPQGS.GPTLSttDhppRKhGlI+hIYohlATplN+schuK.KISpsNFhMPp-FWpEFK..hpsIsspssI-..sphLpcSIscuIst.LDpscFhcKHs-+Kpp.IsppR.tlhppDE.INcIIop+shh.QQREAtNTcGYIYLAsp+NTL.cYhhphpppps.hllLAl.-sIFotKhLEpD.QEPcsAVRYpGul.ot-LpFVNpEGQlssh.hShu....G-hILs..pVIsFh+K	GLNLFRMVRNNPITLRDDDGLEPKKAEDGYYYHLTNARNLMSIVEKGFIPQGSQGPTLSAGDLENRKKGVIRYIYTKVATELNRGEISKNKISSNNFKMPSDFWSEFKLEGSSITNDNDIESVNKKLNDSIVRGISAVLDKGEFKKKHNEKKSEDITRSRMRVMDDDE.INKIITQKPLLEQQREAANTKGYIYLAATRNTLEKYAINYKSSNDDMILLAIPDSIFSAKILEEDEQEPDCAVRYSGGVLSADLRFVNREGQVVPFEYSAS....GEIILDYPSVINFIRK	0	0	1	1
+15495	PF15635	Tox-GHH2		GHH signature containing HNH/Endo VII superfamily nuclease toxin  2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic s[AGP]HH signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type secretion system [1].	25.00	25.00	49.60	48.70	22.40	19.80	hmmbuild  -o /dev/null HMM SEED	106	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.65	0.72	-10.50	0.72	-3.68	21	50	2012-10-09 14:59:33	2012-10-09 15:59:33	1	7	48	0	12	40	2	100.90	30	23.52	NEW	pTGHHLIsspphpstst...............ptYspspAPslCs-Gssps.sGoHGphHsthpshththt............t.t.spastusspsssuhs..csastspCsccClctQLssaac	...QTuHHLIsspth+stup...............ssYocscAPslCsEGssps..sGoHGthHsthsshhtcpp...........hstp.tsassAcspshsuhu..pshstspCs+cCLcuQL-saap..........	0	1	8	11
+15496	PF15636	Tox-GHH		GHH signature containing HNH/Endo VII superfamily nuclease toxin	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive  of this domain at their C-terminus [1].	25.00	25.00	27.50	26.40	24.20	24.80	hmmbuild  -o /dev/null HMM SEED	79	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.27	0.72	-9.36	0.72	-4.34	38	392	2012-10-09 15:03:10	2012-10-09 16:03:10	1	43	112	0	171	362	1	78.50	52	3.34	NEW	-cE+pRllccA+pcAlcpAWpcE+ptlcsGtt.GstsWocsE+ppLLssGpVs............GY-Ghahhsl......ppYPcLA-sstNIpFh+	.......-EEKsRlL-hARQRAlspAWs+EQQ+l+-GcE.GsRtWTEGEKpQLLosG+Vp............GY-GaaVlSV......EQYP...ELADSusNIpFhR............	0	29	40	94
+15497	PF15637	Tox-HNH-HHH		HNH/Endo VII superfamily nuclease toxin with a HHH motif	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with characteristic conserved s[GD]xxR and HHH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system [1].	27.10	27.10	29.80	29.00	25.30	23.50	hmmbuild  -o /dev/null HMM SEED	117	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.81	0.71	-10.37	0.71	-4.31	9	31	2012-10-09 15:05:23	2012-10-09 16:05:23	1	6	29	0	6	30	1	111.30	43	22.97	NEW	phsshssthlsDP+hsV-MsahG+GpssTNut.GWhRssKhFWpchhctpP-hhSpsNptpI.cpGh....uPhlDssalKaFPpa..sshhsDsLhHHHlGtGupAsslPssLHsG....GGlHshc	................chsph.sphhhDP+lsV-MsahGKGptsTNAt.GW.RssKhaapphhcp.pPE.haStpNpt+I.cpGh....sPllDppFlKHFPQY..sshhsDsLhHHHIGt.GGQAsAlPpsLHPGh...GGIHNhE.......	0	0	1	2
+15498	PF15638	Tox-MPTase2		Metallopeptidase toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	25.00	25.00	33.30	32.50	22.80	22.60	hmmbuild  -o /dev/null HMM SEED	194	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.63	0.71	-11.34	0.71	-4.78	6	10	2012-10-09 15:10:23	2012-10-09 16:10:23	1	2	9	0	2	10	0	186.80	24	14.59	NEW	DYFsssG+FI+ss.ps+ssNIYIpsssGN.llhSsYsh+.......pucNhQhhANIsuHYAKtlGlc.........ttsolGspu.tcpsspuchssss.pGtpIpsushNGahcphhsNhYNLpSTLtHEshHp..spRstsc.....scll+..Vlh+phps.cFu+TTpsF+puhAthhpchlpsAYtpssp..Ntshscs.Khlsphspssshphh	..........................DYFsspG+FI+ss.ps+ss.IYIppspsN.llhSphshp........tpshphhhpIshHYAptsGlp.........ttsslGssu.tspsspuphsAss.pstpIphtlpsGahs+phsNhYNLpSTLhHEshHp..ptRGssc.....scllc..Vlh+phcs.cFs+TTpsF+cupAshhpchLpphhtpssp..pthhtcs.chlst.thpss.ph..........................................	0	1	1	2
+15499	PF15639	Tox-MPTase3		Metallopeptidase toxin 3	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	25.00	25.00	26.50	157.80	23.60	20.80	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.86	0.71	-4.41	6	6	2012-10-09 15:10:47	2012-10-09 16:10:47	1	2	5	0	5	6	1	138.70	31	33.31	NEW	pt+KYP+LsaYLKasls..sl.l+sPsllpAhtKhutlscuplp-uLsWGKGPpIpIsshss......................AhGthoPsppuppl.pIctcLVspaEpups.c..pththallttTlLHELlHWuccpsGlD.PGEE.......GctFEc.lYGp	..t+KYP+LsaYLKasls..sl.l+sPsllpAhtKhutlscuplp-uLsWGKGPpIpIsshss......................AhGthoPsppuppl.pIctcLVspaEpups.c..pththallttTlLHELlHWuccpsGlD.PGEE.......GctFEc.lYGp.	0	1	5	5
+15500	PF15640	Tox-MPTase4		Metallopeptidase toxin 4	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	25.00	25.00	31.90	31.80	24.90	24.00	hmmbuild  -o /dev/null HMM SEED	132	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.70	0.71	-10.64	0.71	-4.51	7	110	2012-10-09 15:11:08	2012-10-09 16:11:08	1	13	105	0	3	60	0	125.40	78	16.88	NEW	-th.VSGQs.+ls.sGpRlhslp-hKsa+K-MsphGIKV.IDKKspIL.....PpssAuGFDPhTGcIhLRpcsohlsshHEshHAcQWhcLGKEsYhpQotLEREEaVaNEIMKNKthFscuEIhaup+YIapLRst	..........DGRRVSGHTGFL..DGVRLSR.SQINNIAKEMEKLGIKV.IRKADKYL.....PPNARAAFDYGLRNIYLRKNATLYEVYHEVIHAKQFAKIGREAYEALGRLSR..........EEHVLNEILKSK...NLFNEAEIAHAIKYVEGLREK...	0	1	2	2
+15501	PF15641	Tox-MPTase5		Metallopeptidase toxin 5	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A zincin-like metallopeptidase domain found in bacterial polymorphic toxin systems [1].	107.40	107.40	190.70	189.70	25.20	18.00	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.93	0.72	-10.35	0.72	-4.08	5	5	2012-10-09 15:11:30	2012-10-09 16:11:30	1	3	3	0	1	4	0	109.20	79	12.30	NEW	DLGHVTGSTARARNKEITAILKEDFAYLKLTYIPQYNPFMRTGIAKLGEGTQFGKNSFSSRAELRDVIIHEELHHRWWKRGLNDHHPK.GTEMEQKFYETIRRYKRMRGW	DLGHVTGSTARARNKEITAILKEDFAYLKLTYIPQYNPFMRTGIAKLGEGTQFGKNSFSSRAELRDVIIHEELHHRWWKRGLNDHHPK.GTEMEQKFYETIRRYKRMRGW	0	0	1	1
+15502	PF15642	Tox-ODYAM1		Toxin in Odyssella and Amoebophilus	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted all-alpha fold toxin present in bacterial polymorphic toxin systems of the endosymbionts Odyssella and Amoebophilus [1].	25.00	25.00	665.80	665.80	23.20	21.20	hmmbuild  -o /dev/null HMM SEED	385	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.70	-11.50	0.70	-12.22	0.70	-5.80	3	3	2012-10-09 16:09:44	2012-10-09 17:09:44	1	3	1	0	3	4	0	385.30	52	22.38	NEW	LKEHFKTtAoQuo.GAWKAulPV..KDI-psLSlpEQcALQQADKIVLDYNAKYpQsVp.NLSRFS+uKQQFSKAFuKTAQVoKDAVLGP-INSLp+LQQcVNuAYGSEVlKLDpGRhERNHcERps-lTTSHQQ+EEuLE+K+-cISuQL+..lsP++RlEL++cpspLssQLtEEEElYclALKRLsNPAQoALEDFYDWKRSVFHDFTKLHLGNaLITYEALALGTVARHPEAYEpsLQGSTAIGSVLADAFLPLGGLLGNVIGKIAEcGAELYADKQIRIKAAKIGSLYGHKGLEGMVALTREVANGLLFRLKDVIIDLTPESLDKLAKVATTQMIDYALKh..WEcNs.sQTINAhNLLL+GTQHQPSWhKuFTQsssLEpEDGRaVDG	LKEHFKTtAoQuo.GAWKAulPV..KDI-psLSlpEQcALQQADKIVLDYNAKYpQsVp.NLSRFS+uKQQFSKAFuKTAQVoKDAVLGP-INSLp+LQQcVNuAYGSEVlKLDpGRhERNHcERps-lTTSHQQ+EEuLE+K+-cISuQL+..lsP++RlEL++cpspLssQLtEEEElYclALKRLsNPAQoALEDFYDWKRSVFHDFTKLHLGNaLITYEALALGTVARHPEAYEpsLQGSTAIGSVLADAFLPLGGLLGNVIGKIAEcGAELYADKQIRIKAAKIGSLYGHKGLEGMVALTREVANGLLFRLKDVIIDLTPESLDKLAKVATTQMIDYALKh..WEcNs.sQTINAhNLLL+GTQHQPSWhKuFTQsssLEpEDGRaVDG	0	3	3	3
+15503	PF15643	Tox-PL-2		Papain fold toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A papain fold toxin domain found in bacterial polymorphic toxin systems [1]. 	25.00	25.00	26.00	90.80	24.00	23.10	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.37	0.72	-4.03	10	11	2012-10-09 16:10:18	2012-10-09 17:10:18	1	3	9	0	4	16	0	98.80	33	18.26	NEW	s.spl+QtIusIusc.F.p..laQChcCApAlcpaLppptIsGKlI+LpTt.spssa..Ias-tl..p...poIopNGpH.GItVt....shVFDNlascGlsRc-Wlpshps	....spltQtIspIssp.a.t..lhpC.pCApAltpaLppptIpGKlIcLpTt.pptsa..Ihs-tl..p...poIopNGpH.GltVt....shVFDNlpspGlsRc-Wlpsht...	0	1	4	4
+15504	PF15644	Tox-PL		Papain fold toxin 1	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A papain fold toxin domain found in bacterial polymorphic toxin systems. In these systems they might function either as a releasing peptidase or toxin [1].	24.10	24.10	24.50	24.10	23.40	22.00	hmmbuild  -o /dev/null HMM SEED	111	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.67	0.72	-10.64	0.72	-3.32	46	104	2012-10-09 16:13:10	2012-10-09 17:13:10	1	16	86	1	28	91	0	112.80	19	12.33	NEW	pNChsCslAstssht..GtshsAtPph.tt..................sppsshshhpphhu..............tp.ht.h...................sshptltptlpstspGupullhsph.............tsts......GHshsll..ppsGs..lhalDsQsGpss	........................................................NC.sCshuhthpht..GhshpAtsth.t...................stpsshshhpphhu..............t...h......................sstphhpphlpshspGutshlhhth..............tsts........uHshssh..hpsGp..lhalDsQsGp..h......	0	11	22	26
+15505	PF15645	Tox-PLDMTX		Dermonecrotoxin of the Papain-like fold	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A papain fold toxin domain found in bacterial polymorphic toxin systems [1]. 	26.10	26.10	26.80	27.00	20.70	25.40	hmmbuild  -o /dev/null HMM SEED	135	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.75	0.71	-11.04	0.71	-4.12	14	38	2012-10-09 16:45:02	2012-10-09 17:45:02	1	5	35	0	8	29	1	134.70	47	14.49	NEW	ssPhspCcsuhp.lsshh+.ptsh..psl+htslhh......W.psu...sc-hshNHalVlu+hsshcYVhDsTAcQFpsht................sp..sPlltstssWh.t...+aptuhpcKhlhhtchss...sphutssapt..t...hss.cslpssphLspPpWY	..............h.NPlGQCESLMTPVSsFMp.-KGF..-NIRYRGIaI......W..Dcs...TEElPpNHFAVVGsK-GKDYVFDlSAHQFcN+Gh...............SsLsGPLILoAD-Wls....KYRh..Ao++KLIhYsDFuN...uulAusuacALsc...chpsEohsGclhlTSPRWF.......................................	0	1	4	6
+15506	PF15646	Tox-REase-2		Restriction endonuclease fold toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 7 or PrsW-peptidase dependent secretion system [1].	67.30	67.30	109.90	109.20	25.30	21.40	hmmbuild  -o /dev/null HMM SEED	125	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.82	0.71	-10.60	0.71	-4.25	7	7	2012-10-09 16:47:01	2012-10-09 17:47:01	1	2	6	0	4	7	0	127.40	32	25.86	NEW	spsAYQhclAGYPEhclslP...upcpslhsDGhRsp...DGhhl-AKaVscPspsph..........p.lcplchpppupht.....DhhhcpDccELp+YstAhsss.spph+GlEIVTNs..................-ussYWpshMAhhGVs	spsAYQhclAGYPEhclslP...upcpslhsDGhRsp...DGhhl-AKaVscPspsph..........p.lcplchpppupht.....DhhhcpDccELp+YstAhsss.spph+GlEIVTNs..................-ussYWpshMAhhGVs	0	1	2	4
+15507	PF15647	Tox-REase-3		Restriction endonuclease fold toxin 3	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or PrsW-peptidase dependent secretion system [1].	25.00	25.00	36.00	68.00	22.20	20.50	hmmbuild  -o /dev/null HMM SEED	109	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.81	0.72	-10.19	0.72	-4.25	5	39	2012-10-09 16:47:57	2012-10-09 17:47:57	1	7	38	0	3	32	0	108.70	62	15.12	NEW	puuKh+sstscpYEDhlREKLGGpS+lltu.....REaDAVTDchlAQsKcolSuIcpPKNFLNKKsRcQIKATIEAApQQGK+ApFWFKhc....VpscV+EYIEp+GGcVIIsocs	........ppuKhREALDlHYEDLlRRKLGG.Sp.IsG.....REaDsVTDchIAQsKRThSuIDpPKNFLsKpsRsQIKtTIEhAcpQGKcApFWFKYG....VpsKV+EYIESKGGcVllGhG.s	0	1	2	2
+15508	PF15648	Tox-REase-5		Restriction endonuclease fold toxin 5	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or PrsW-peptidase dependent secretion system. Versions of this domain are also found in caudoviruses [1].	25.00	25.00	34.30	33.40	24.80	23.90	hmmbuild  -o /dev/null HMM SEED	95	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.52	0.72	-10.38	0.72	-3.70	66	128	2012-10-09 16:49:27	2012-10-09 17:49:27	1	5	85	0	41	164	2	94.30	33	27.11	NEW	tshpYQtpITG.hs.......hshphtht..t.............................h.h.slcFDGapss...pslLhEAKu..sY.c.pFhc.pst...p.st.h.............hpuhcsh...hcQupcQspssps.t.s.splcWaFtp.	....shcYQtplTG.hs.......hsh.-.ht.hs...pp............................h.h.slcFDGFpss...cChLhEAKu..sY.c.pFhs.ssh...p..t.h.............hpGhpsh.hppApcQsssscs.s.sssplcWaFtp...........	0	3	9	21
+15509	PF15649	Tox-REase-7		Restriction endonuclease fold toxin 7	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, or type 7 secretion system [1].	25.00	25.00	27.60	28.40	23.30	22.70	hmmbuild  -o /dev/null HMM SEED	87	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.36	0.72	-9.87	0.72	-3.85	21	52	2012-10-09 16:49:57	2012-10-09 17:49:57	1	10	43	0	15	60	0	86.20	34	11.40	NEW	tGptuEppss.sht.......tspcplsstss.......tpRIPDshsp.spplsEVKNVpcl..shopQl+s.sphApppGhphsLlVs..csTplS.psL	........................h.GctuEhtAuhhhs.......us++plssshs.tt....tppIPDhls..p.sc..slsEVKNVpc...uhTcQlptplchApp.thchhLlss..chTclst.........	0	4	9	14
+15510	PF15650	Tox-REase-9		Restriction endonuclease fold toxin 9	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the restriction endonuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 7 secretion system [1].	25.00	25.00	30.10	29.10	23.10	20.90	hmmbuild  -o /dev/null HMM SEED	89	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.46	0.72	-9.81	0.72	-3.78	11	16	2012-10-09 16:50:23	2012-10-09 17:50:23	1	7	15	0	9	17	0	83.00	43	6.76	NEW	thopSuh+hGRphHKsYKsu.h.....st.KEFpLPSG+RhD..FlDa-s..KhIYELKPsNP+uIKcGhKQLcsY+pElcphh........GtsWpslL-TY	.t.hopSuh+hGRphHKsYKhs.......shpKEF+LP..SGK..RhD..hlDhps..+hIYELKP.NP+uIKpGhKQLcsY+pElpph.........GtsWpshl-sY......	0	4	9	9
+15511	PF15651	Tox-SGS		Salivary glad secreted protein domain toxin	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	An alpha+beta fold domain with four conserved cysteine residues and a conserved [DE}xx[ND] motif. This domain is mainly present at the c-terminus of RHS repeats containing proteins in insects and crustaceans. Although no bacterial homologs have been identified, the domain architecture suggests an origin from bacterial polymorphic toxin systems [1]. 	25.00	25.00	29.20	27.80	18.20	17.60	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.35	0.72	-4.23	18	21	2012-10-09 16:50:45	2012-10-09 17:50:45	1	2	6	0	14	21	0	97.10	33	3.39	NEW	pNCa....ssss-tsplpCYppcupsplFs+ss........phhspDpassChPlpapGpPSluCcGppooalYTPhps....s+hFDhlDGWLhLApVuPsslRNlppsh	......................NCa....s.ssphshlhCapppuhshlFs+ss........pshspDpassChPlpapGpPSluCcGppooalYTPhps....schFDhlDGWLhLApVuPssl+slpph................	0	3	4	14
+15512	PF15652	Tox-SHH		HNH/Endo VII superfamily toxin with a SHH signature	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with two conserved histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6 or type 7 secretion system [1].	22.70	22.70	23.80	24.60	21.60	21.40	hmmbuild  -o /dev/null HMM SEED	100	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.72	0.72	-10.63	0.72	-3.42	14	38	2012-10-09 16:51:09	2012-10-09 17:51:09	1	12	37	0	9	38	1	91.60	36	20.28	NEW	.suhlQSHHsIQDtWAc....pslssYspc..tAPshLl.Ssst.sHAtloA...tpRscRsupG......WsoslpcEFstuhpE.Mh-.AGVsppssc+sh+c..uY+YFD	...su.lpsHHul.DhWAc....pNlssYstc..tsssslh.otc...Hshhpss.pthhhc+sucs.sGK..Wpos.pcEhpphscc.Mh-.AsVscpstpphhcs..pYpah...	0	1	5	8
+15513	PF15653	Tox-URI2		URI fold toxin 2	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the URI nuclease fold present in bacterial polymorphic toxin systems. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1].	25.00	25.00	25.60	25.20	22.10	20.00	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.93	0.72	-10.04	0.72	-3.79	13	44	2012-10-09 16:52:12	2012-10-09 17:52:12	1	9	34	0	16	47	0	76.20	23	13.91	NEW	.chupccshuYphhcKs-....laKlGEos.....ppps.sh+sRhstphLc+ssup...................hphlpcss....t..sKpsspphEst+lppapcppG	.......p.spcpshsYthhccss....lhKhGcos.....tpts.ssctRhphphLpcpssp...................hphhspss........s+pphpphEptclpth................	0	7	13	14
+15514	PF15654	Tox-WTIP		Toxin with a conserved tryptophan and TIP tripeptide motif	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin domain with two membrane spanning alpha helices and RxxR, Wx[ST]IP motifs. The domain is present in bacterial polymorphic toxin systems. The toxin is usually exported by the type 2 or Photorhabdus virulence cassette (PVC)-type secretion system [1].	25.00	25.00	81.00	79.70	21.00	19.70	hmmbuild  -o /dev/null HMM SEED	54	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-8.82	0.72	-4.35	7	9	2012-10-09 16:52:36	2012-10-09 17:52:36	1	5	9	0	1	10	0	54.00	48	9.63	NEW	.phsssssshsss-sussssAusGsuYllYRslRhlPSLhPPLW.TIPANlAhP	.p.phssssoshoTs-sussssAslGsGYlIYRslRhlPSLhPPLWhoIPANlssP	0	0	0	1
+15515	PF15655	Imm-NTF2		NTF2 fold immunity protein	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted immunity protein of the NTF2 fold. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, which usually contains toxin domains of the Tox-JAB-2 family [1].	25.00	25.00	27.70	27.40	21.70	20.70	hmmbuild  -o /dev/null HMM SEED	130	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.91	0.71	-11.00	0.71	-3.68	32	92	2012-10-09 18:50:36	2012-10-09 19:50:36	1	3	74	0	15	92	2	130.10	21	66.80	NEW	.ppscphlhs...FhttMppWEp...h.....ppht.pp.t.............hppclpsIappasTcK...pRptut....shSh...G.PspYs.ppt....hl-h..pptspsplhl.hp..pps...thptc.acahlhhpsscWhIDp....hppc........-pWppsh.	.............................................h...hpphl.tFhtthppaEt.h.......pt.s.pp......................t.hppclttlappaso-K....+htst...hshSa...u.supYss.p.....hl-h..cphscsclhlht..ppp....hphc.hpFlhhhhsspWhIDp....hppc........ctWpps..h.......	0	2	9	9
+15516	PF15656	Tox-HDC		Toxin with a H, D/N and C signature	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted alpha/beta fold peptidase domain with a strongly conserved triad of a histidine, aspartate/asparagine and cysteine residues that are predicted to comprise the active site of the predicted peptidase. Proteins bearing this predicted toxin domain are particularly common in both intracellular and extracellular pathogens [1].	25.00	25.00	28.30	27.40	20.40	19.30	hmmbuild  -o /dev/null HMM SEED	119	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.62	0.71	-10.73	0.71	-3.90	9	20	2012-10-09 19:11:59	2012-10-09 20:11:59	1	5	16	0	5	19	0	116.40	28	18.40	NEW	tlaGscsphtshc.lptslpsIs+p.S..spsIhIlSGoHGhssG.........pNWhtps.........lRcPpl.h-hpFhtpDhpshpt....hscplhlhDlssss.tchss..lpss......ssphILuYCaStsDpsht.	.........................lhstptth.sht.lptshphlt+p.s.sstcIhIlSGoHGtssG.........pNasups...............lRcPsl.hE+tFahEDlpsap.t...........hstpV+lhDlushop.pEhss.plpss......spplIhGaCaSpsDchhh.h....	0	1	2	4
+15517	PF15657	Tox-HNH-EHHH		HNH/Endo VII superfamily nuclease toxins	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic conserved [ED]H motif and two histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system [1].	25.00	25.00	26.70	26.60	23.40	23.40	hmmbuild  -o /dev/null HMM SEED	72	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-8.75	0.72	-9.70	0.72	-3.83	33	80	2012-10-09 19:15:32	2012-10-09 20:15:32	1	26	69	0	26	75	0	66.90	30	8.65	NEW	tlhcpsspshhsRpYcFpsscG.....ppllIp-HotGHths.....tspsPHFNsts.cs...........................hpsGphsspcsHYsa	.......hhsspspshhsR.acapshcG.........pKhlIp-HotG+th.......spuPHapsts.pp............................h.c.puphstp.psHY.a.......................	0	2	9	18
+15518	PF15658	Latrotoxin_C		Latrotoxin C-terminal domain	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	A toxin domain present in arthropod alphaproteobacterial, gammaproteobacterial endosymbionts and also at the C-termini of the latrotoxins of the black widow spider. The domain is characterized by a conserved, hydrophobic helix and is predicted to associate with the cell membrane [1].	25.00	25.00	46.20	43.40	24.70	22.60	hmmbuild  -o /dev/null HMM SEED	127	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-9.89	0.71	-10.46	0.71	-4.31	8	23	2012-10-09 19:27:40	2012-10-09 20:27:40	1	16	8	0	8	25	0	126.00	38	6.65	NEW	phDsNuslhLLDlLIRKlTspKYhsT....sc.polSPLEApGYALsIsKcFEcVlc.QAulKSGISh+cLNIDhlElQcpIssK..ItSGKFsEISulLsSYlEcAhPs......ucLS.Kph-KFhspFNscl-.....slLNp	......hDVNGslhLLDlLIRKhoupKYhss....sc....pSISsLEAQuYALsIsc+FEcVLp.psulKuGlShcpLNlDhstlQpcIhtK..lhuG+FsEIuthLsSasccAhPt......upLp.KphcKFh.pFppthc.hlp.............	0	0	2	2
+15519	PF15659	Toxin-JAB1		JAB-like toxin  1	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	\N	26.40	26.40	26.40	26.60	25.60	25.70	hmmbuild  -o /dev/null HMM SEED	162	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.71	-10.07	0.71	-11.36	0.71	-4.36	13	24	2012-10-10 14:49:21	2012-10-09 20:38:55	1	2	16	0	6	24	1	153.20	26	34.55	NEW	p+ss+las....phtsusps-phhssp.ts..psIpl.spsll...uphsp..tpsppG....thpoas....oTssspsAtslFcFsA-NTo..VEWpLsshp.-sGs.pshsltTspcptuspss..hsph.pc.htssuphlhc..IHSH...........Ptss.....tsS.....hsDhphup.tps..........huhYhpc.......tthhphYs	......................ppssclhp.....hhpssps-phh.hp.ts..psIpl.sppll...sthhp..tpsppG....hhpoas....sTss.csAtslFcFsA-NTo..VEWpLssht.-p....Gs.pshhlsTsppppuVt....hs.htpc.h.stsphlIc..hHSH...........Phss....tsS.....spDhpshp.hps...........shahcc........t.h..Y................	0	6	6	6
+15520	PF15660	Imm49		Immunity protein 49	Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L, Finn RD	rdf	[1]	Family	\N	25.00	25.00	168.90	168.80	24.80	19.60	hmmbuild  -o /dev/null HMM SEED	84	hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq	0.72	-9.17	0.72	-9.79	0.72	-3.94	4	10	2012-10-09 20:02:34	2012-10-09 21:02:34	1	1	10	0	0	10	0	82.90	99	96.96	NEW	hRALVALKRELLPGVTTFIDSVRLEAIDDKADRLMVTTSVGEEARLVYFNPDFAGTPTFGRRLYRLRDWTDDLADWVDRLRRER	VRALVALKRELLPGVTTFIDSVRLEAIDDKADRLMVTTSVGEEARLVYFNPDFAGTPTFGRRLYRLRDWTDDLADWVDRLRRER	0	0	0	0
diff -r 000000000000 -r 68a3648c7d91 pfam_search/pfamA.txt.gz
Binary file pfam_search/pfamA.txt.gz has changed
diff -r 000000000000 -r 68a3648c7d91 pfam_search/pfam_filter.xml
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/pfam_filter.xml	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,17 @@
+<tool id="pfam_Filter" name="PFAM search" version="0.">
+ <description>keyword search on PFAM annotations</description>
+ <command> /home/inmare/galaxy/tools/pfam_search/annota.Filter.pl $prot $pfam $out $search</command>
+ <description> "approved by the boss" </description>
+ <inputs>
+ 	<param name="prot" type="data" format="fasta" label="protein file used as input with pfamScan" help="fasta only"/>
+ 	<param name="pfam" type="data" format="tabular" label="pfamScan output" help="this file should match the protein file"/>
+ 	<param name="search" type="text" label="regular expression to search" help="case sensitive!"/>  
+ </inputs>
+ <outputs>
+ 	<data name="out" ftype="tabular" format="html" label="annotated pfam file"/>
+ </outputs>
+ <test/>
+ <help>
+	This tool performs keyword searches in order to facilitate the retrieval of proteins containing functional domains of interest from a PFAM annotation. Keyword searches are performed through a simple Perl script implementing exact searches of user specified keywords within the description of each PFAM domain as reported in the clans.txt or pfam.txt domain description files.  Searches can be performed using logical connectors, AND, OR and NOT.  When multiple keywords are entered, the default is to use the AND connector. 
+ </help>
+</tool>
diff -r 000000000000 -r 68a3648c7d91 pfam_search/prots
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/prots	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,80 @@
+>PROKKA_00001 Mercuric resistance operon regulatory protein
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSA
+QRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHAR
+KGNVSCPLIASLQGEAGLARSAMP*
+>PROKKA_00002 MerT mercuric transport protein
+MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTVLEPYRPLFIGAALV
+ALFFAWKRIYRPVQACKPGEVCAIPQVRATYKLIFWIVAVLVLVALGFPYVVPFFY*
+>PROKKA_00003 Mercuric transport protein periplasmic component precursor
+MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKR
+EAVVTFDDTKASVQKLTKATADAGYPSSVKQ*
+>PROKKA_00004 Mercuric resistance protein MerC
+MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQYEGLFISRLLPLFAAL
+AFLANALGWFSHRQWLRSLLGMIGPAIVFAATVWLLGNWWTANLMYVGLALMIGVSIWDF
+VSPAHRRCGPDGCELPAKRL*
+>PROKKA_00005 Mercuric reductase
+MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIEVGTSPDALTAAVAGL
+GYRATLADAPSVSTPGGLLDKMRDLLGRNDKTGSSGALHIAVIGSGGAAMAAALKAVEQG
+ARVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIAATTPTIQRTALLAQ
+QQARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQLNDGGERVVAFDRCLIATG
+ASPAVPPIPGLKDTPYWTSTEALVSETIPKRLAVIGSSVVALELAQAFARLGAKVTILAR
+STLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYINGEGDGEFVLTTAHGELRADKL
+LVATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVEHIYAAGDCTDQPQFVYVAAAA
+GTRAAINMTGGDAALNLTAMPAVVFTDPQVATVGYSEAEAHHDGIKTDSRTLTLDNVPRA
+LANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLT
+MVEGLKLAAQTFNKDVKQLSCCAG*
+>PROKKA_00006 zinc-responsive transcriptional regulator
+MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDAALQRLCFVRAAFEAG
+IGLDALARLCRALDAADGAQAAAQLAVLRQLVERRRAALAHLDAQLASMPAERAHEEALP
+*
+>PROKKA_00007 MerE protein
+VNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAGAFLGEHWGVAALALT
+GLFVLAVTRLLRAFRGGS*
+>PROKKA_00008 Phytochrome-like protein cph2
+MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALMRWRHPRLGLLPPGQF
+LPLAESFGLMPEIGAWVLGEACRQMHKWQGPAWQPFRLAINVSASQVGPTFDDEVKRVLA
+DMALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDFGTGYSCLQHLKCCPITT
+LKIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLHQLIGRNGCCAASS*
+>PROKKA_00009 Transposon Tn7 transposition protein TnsB
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVY
+VLIRRARQGSGLVTDLVPGQSGGGKGKGRLPEPVERVIHELLQKRFLTKQKRSLAAFHRE
+VTQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQV
+QIDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVAC
+DKRPWLEGLNVEMDWQMSGKPLLLYLDNAAEFKSEALRRGCEQHGIRLDYRPLGQPHYGG
+IVERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVH
+NGLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHC
+CK*
+>PROKKA_00010 Integrase core domain protein
+MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHSTIYRWVQRYAPEMEK
+RLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDFYLSSRRNSKAAYRFLG
+KILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHRQIKYRNNVIECDHGKLK
+RIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPLGEMRLVSRVFEM*
+>PROKKA_00011 DNA-binding transcriptional regulator LysR
+MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH*
+>PROKKA_00012 hypothetical protein
+MPSRFLTPYIPLVNLFSLHVYELILVTTKPKFEL*
+>PROKKA_00013 Sodium/glutamate symport carrier protein
+MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFT
+FDASLQSLLMLTFFSSIGLSSDFSRLIKGGKPLVLLTIAVTILIAIQNTVGMSMAVMMNE
+SPFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVAR
+HLLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKD
+TFLQLPTFVWCLFVGIIIRNTLTHVFKHEVFEPTVDVLGSVALSLFLAMALMSLKFGQLA
+SMAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTV
+TKAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT*
+>PROKKA_00014 Antibiotic biosynthesis monooxygenase
+MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLATEGKMLSLSWWENEY
+AVLQWKNHVLHAKAQQEGRESIFDFYKISIAHITREYSFKKDKDNV*
+>PROKKA_00015 hypothetical protein
+MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHFLVEQGKEAKIALEQA
+GLLVLAIRTPLIRKLKQEKPGELGEIARVLAENNINILVQYSDHANQLILITDNDSMAAS
+VTLPWAIK*
+>PROKKA_00016 Helix-turn-helix domain protein
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFR
+LAGKDIAELMESMMGISLNHGVHARVSTPVHLRKARTCYDHLAGEVAVKIYDSLCQQQWI
+TENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKG
+WLTRHLGYREVTITEKGYAAFKTHFHI*
+>PROKKA_00017 Tetracycline repressor protein class B from transposon Tn10
+MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEML
+DRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFL
+CQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQ
+GAEPAFLFGLELIICGLEKQLKCESGS*
diff -r 000000000000 -r 68a3648c7d91 pfam_search/prova
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/prova	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,536 @@
+<html>
+<head></head>
+<body>
+Proteins with PFAM domains:
+<br><br>
+<div>
+<table cellpadding="0" width=950>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00001</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSAQ<br>RLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHARK<br>GNVSCPLIASLQGEAGLARSAMP*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00376> PF00376</a>merR; <br>MerR family regulatory protein Prosite & Pfam-B_3021 (Release 7.5) 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF09278> PF09278</a>MerR, DNA binding<br>Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00002</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSEPQNGRGALFAGGLAAILASTCCLGPLVLVALGFSGAWIGNLTVLEPYRPLFIGAALVA<br>LFFAWKRIYRPVQACKPGEVCAIPQVRATYKLIFWIVAVLVLVALGFPYVVPFFY*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02411> PF02411</a>MerT mercuric transport protein<br>MerT mercuric transport protein MerT is an mercuric transport integral membrane protein and  is responsible for transport of the Hg2+ iron from periplasmic  MerP (also part of the transport system) to mercuric reductase (MerE). 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00003</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MKKLFASLALAAAVAPVWAATQTVTLAVPGMTCAACPITVKKALSKVEGVSKVDVGFEKRE<br>AVVTFDDTKASVQKLTKATADAGYPSSVKQ*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>Heavy-metal-associated domain<br>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00004</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MGLMTRIADKTGALGSVVSAMGCAACFPALASFGAAIGLGFLSQYEGLFISRLLPLFAALA<br>FLANALGWFSHRQWLRSLLGMIGPAIVFAATVWLLGNWWTANLMYVGLALMIGVSIWDFV<br>SPAHRRCGPDGCELPAKRL*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03203> PF03203</a>MerC mercury resistance protein<br>MerC mercury resistance protein 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00005</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSTLKITGMTCDSCAVHVKDALEKVPGVQSADVSYAKGSAKLAIEVGTSPDALTAAVAGLG<br>YRATLADAPSVSTPGGLLDKMRDLLGRNDKTGSSGALHIAVIGSGGAAMAAALKAVEQGA<br>RVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRESPFDGGIAATTPTIQRTALLAQQ<br>QARVDELRHAKYEGILEGNPAITVLHGSARFKDNRNLIVQLNDGGERVVAFDRCLIATGA<br>SPAVPPIPGLKDTPYWTSTEALVSETIPKRLAVIGSSVVALELAQAFARLGAKVTILARS<br>TLFFREDPAIGEAVTAAFRMEGIEVREHTQASQVAYINGEGDGEFVLTTAHGELRADKLL<br>VATGRAPNTRKLALDATGVTLTPQGAIVIDPGMRTSVEHIYAAGDCTDQPQFVYVAAAAG<br>TRAAINMTGGDAALNLTAMPAVVFTDPQVATVGYSEAEAHHDGIKTDSRTLTLDNVPRAL<br>ANFDTRGFIKLVVEEGSGRLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTM<br>VEGLKLAAQTFNKDVKQLSCCAG*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00403> PF00403</a>Heavy-metal-associated domain<br>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF07992> PF07992</a>Pyridine nucleotide-disulphide oxidoreductase<br>Pyridine nucleotide-disulphide oxidoreductase This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a> FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site  .  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00070> PF00070</a>pyr_redox; <br>Pyridine nucleotide-disulphide oxidoreductase Sonnhammer ELL, Griffiths-Jones SR This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.  This domain is actually  a small NADH binding domain within a larger FAD binding domain. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0063> CL0063</a> FAD/NAD(P)-binding Rossmann fold Superfamily A class of redox enzymes are two domain proteins. One domain, termed the catalytic domain, confers substrate specificity and the precise reaction of the enzyme.  The other domain, which is common to this class of redox enzymes, is a Rossmann-fold domain. The Rossmann domain binds nicotinamide adenine dinucleotide (NAD+) and it is this cofactor that reversibly accepts a hydride ion, which is lost or gained by the substrate in the redox reaction.  Rossmann domains have an alpha/beta fold, which has a central beta sheet, with approximately five alpha helices found surrounding the beta sheet.The strands forming the beta sheet are found in the following characteristic order 654123. The inter sheet crossover of the stands in the sheet form the NAD+ binding site  .  In some more distantly relate Rossmann domains the NAD+ cofactor is replaced by the functionally similar cofactor FAD. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02852> PF02852</a>pyr_redox_dim; <br>Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00006</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSAYTVSQLAHNAGVSVHIVRDYLVRGLLRPVACTTGGYGVFDDAALQRLCFVRAAFEAGI<br>GLDALARLCRALDAADGAQAAAQLAVLRQLVERRRAALAHLDAQLASMPAERAHEEALP*<br>
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13411> PF13411</a>MerR HTH family regulatory protein<br>MerR HTH family regulatory protein 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00007</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+VNAPDKLPPETRQPVSGYLWGALAVLTCPCHLPILAAVLAGTTAGAFLGEHWGVAALALTG<br>LFVLAVTRLLRAFRGGS*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF05052> PF05052</a>MerE protein<br>The prokaryotic MerE (or URF-1) protein is part of the mercury resistance operon. The protein is thought not to have any direct role in conferring mercury resistance to the organism but may be a mercury resistance transposon [1,2].  
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00008</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MTSSQPAGWTAAELAQAAARGQLDLHYQPLVDLRDHRIAGAEALMRWRHPRLGLLPPGQFL<br>PLAESFGLMPEIGAWVLGEACRQMHKWQGPAWQPFRLAINVSASQVGPTFDDEVKRVLAD<br>MALPAELLEIELTESVAFGNPALFASFDALRAIGVRFAADDFGTGYSCLQHLKCCPITTL<br>KIDQSFVARLPDDARDQTIVRAVIQLAHGLGMDVIFRRRLHQLIGRNGCCAASS*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00563> PF00563</a>DUF2; <br>Alignment kindly provided by SMART This domain is found in diverse bacterial signaling proteins.  It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function  . The domain contains many conserved acidic residues  that could participate in metal binding and might form the phosphodiesterase active site  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00009</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVYV<br>LIRRARQGSGLVTDLVPGQSGGGKGKGRLPEPVERVIHELLQKRFLTKQKRSLAAFHREV<br>TQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQVQ<br>IDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVACD<br>KRPWLEGLNVEMDWQMSGKPLLLYLDNAAEFKSEALRRGCEQHGIRLDYRPLGQPHYGGI<br>VERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVHN<br>GLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHCC<br>K*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13518> PF13518</a>Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00665> PF00665</a>Integrase core domain<br>Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a> Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00010</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHSTIYRWVQRYAPEMEKR<br>LRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDFYLSSRRNSKAAYRFLGK<br>ILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHRQIKYRNNVIECDHGKLKR<br>IIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPLGEMRLVSRVFEM*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13610> PF13610</a>DDE domain<br>This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a> Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00011</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MKLRHLDIFYAVMTCGSLTRAAEVLHISQPAASKALKHAEH*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00126> PF00126</a>Bacterial regulatory helix-turn-helix protein, lysR family<br>Bacterial regulatory helix-turn-helix protein, lysR family 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00013</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MILDASYTLLVACIALLIGMFVVKFTPFLQKNHIPEAVVGGFIVAIVLLIIDKTSGYSFTF<br>DASLQSLLMLTFFSSIGLSSDFSRLIKGGKPLVLLTIAVTILIAIQNTVGMSMAVMMNES<br>PFIGLIAGSITLTGGHGNAGAWGPILADKYGVTGAVELAMACATLGLVLGGLVGGPVARH<br>LLKKVSIPKTTEQERDTIVEAFEQPSVKRKINANNVIETISMLIICIVVGGYISALFKDT<br>FLQLPTFVWCLFVGIIIRNTLTHVFKHEVFEPTVDVLGSVALSLFLAMALMSLKFGQLAS<br>MAGPVLIIIAVQTVVMVLFACFVTFKMMGKDYDAVVISAGHCGFGMGATPTAIANMQTVT<br>KAFGPSHKAFLVVPMVGAFIVDISNSILIKIFIEIGTYFT*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03616> PF03616</a>Sodium/glutamate symporter<br>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0064> CL0064</a> CPA/AT transporter superfamily This Clan contains transporter proteins that belong to the CPA superfamily and AT superfamily according to TCDB  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00014</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MIAVIFEVQIQPDQQTRYLTLAEELRPLLSHVAGFISIERFQSLATEGKMLSLSWWENEYA<br>VLQWKNHVLHAKAQQEGRESIFDFYKISIAHITREYSFKKDKDNV*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF03992> PF03992</a>Antibiotic biosynthesis monooxygenase<br>Antibiotic biosynthesis monooxygenase This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 (Swiss:Q9X9W3) is  suggestive that the other proteins function as  multimers. There is also a conserved histidine which is likely to be an active site residue. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0032> CL0032</a> Dimeric alpha/beta barrel superfamily This superfamily of proteins possess a Ferredoxin-like fold. Pairs of these assemble into a beta barrel.  The function of this barrel is quite varied and includes Muconolactone isomerase as well as monooxygenases. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00015</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MFDVHVVLDNQIGQLALLGKTLGNKGIGLEGGGIFTVGDECHAHFLVEQGKEAKIALEQAG<br>LLVLAIRTPLIRKLKQEKPGELGEIARVLAENNINILVQYSDHANQLILITDNDSMAASV<br>TLPWAIK*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF01842> PF01842</a>ACT domain<br>This family of domains generally have a regulatory role. ACT domains are linked to a wide range of metabolic enzymes that are regulated by amino acid concentration. Pairs of ACT domains bind specifically to a particular amino acid leading to regulation of the linked enzyme.  The ACT domain is found in: D-3-phosphoglycerate dehydrogenase EC:1.1.1.95 Swiss:P08328, which is inhibited by serine  . Aspartokinase EC:2.7.2.4 Swiss:P53553, which is regulated by lysine. Acetolactate synthase small regulatory subunit Swiss:P00894, which is inhibited by valine. Phenylalanine-4-hydroxylase EC:1.14.16.1 Swiss:P00439, which is regulated by phenylalanine. Prephenate dehydrogenase EC:4.2.1.51 Swiss:P21203. formyltetrahydrofolate deformylase EC:3.5.1.10, Swiss:P37051, which is activated by methionine and inhibited by glycine. GTP pyrophosphokinase EC:2.7.6.5 Swiss:P11585 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0070> CL0070</a> These domains are involved in binding to amino-acids and causing allosteric regulation of linked enzyme domains  . The relationship between these two families was first noticed in  . 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00016</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFRL<br>AGKDIAELMESMMGISLNHGVHARVSTPVHLRKARTCYDHLAGEVAVKIYDSLCQQQWIT<br>ENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKGW<br>LTRHLGYREVTITEKGYAAFKTHFHI*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF12840> PF12840</a>Helix-turn-helix domain<br>This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00017</b><br>
+</center>
+<td bgcolor="#czb9dz">
+<pre> 
+MSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLD<br>RHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLC<br>QQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDHQG<br>AEPAFLFGLELIICGLEKQLKCESGS*
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00440> PF00440</a>tetR; <br>Bacterial regulatory proteins, tetR family 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a> This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF02909> PF02909</a>tetR_C; <br>Tetracyclin repressor, C-terminal all-alpha domain 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0174> CL0174</a> TetR protein, C-terminal domain-like This clan features families of transcriptional regulators for multidrug efflux pumps, which belong to the TetR superfamily. They are induced by the presence of a variety of factors, such as antibiotics or organic solvents. The C-terminal region featured in these families is thought to contain the inducer-binding site; the divergent sequences in this region allow for the binding of a variety of different inducers [1-4]. 
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+</table>
+</div>
+</body>
+</html>
diff -r 000000000000 -r 68a3648c7d91 pfam_search/prova2
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/prova2	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,148 @@
+<html>
+<head></head>
+<body>
+Proteins with PFAM domains:
+<br><br>
+<div>
+<table cellpadding="0" width=650>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00001</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MENNLENLTIGVFAKAAGVNVETIRFYQRKGLLREPDKPYGSIRRYGEADVVRVKFVKSA
+QRLGFSLDEIAELLRLDDGTHCEEASSLAEHKLKDVREKMADLARMETVLSELVCACHAR
+KGNVSCPLIASLQGEAGLARSAM
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF09278> PF09278</a>
+<p align="justify">MerR, DNA binding<br>Members of this family of DNA-binding domains are predominantly found in the prokaryotic transcriptional regulator MerR. They adopt a structure consisting of a core of three alpha helices, with an architecture that is similar to that of the 'winged helix' fold  . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00009</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MATDTPRIPEQGVATLPDEAWERARRRAEIISPLAQSETVGHEAADMAAQALGLSRRQVY
+VLIRRARQGSGLVTDLVPGQSGGGKGKGRLPEPVERVIHELLQKRFLTKQKRSLAAFHRE
+VTQVCKAQKLRVPARNTVALRIASLDPRKVIRRREGQDAARDLQGVGGEPPAVTAPLEQV
+QIDHTVIDLIVVDDRDRQPIGRPYLTLAIDVFTRCVLGMVVTLEAPSAVSVGLCLVHVAC
+DKRPWLEGLNVEMDWQMSGKPLLLYLDNAAEFKSEALRRGCEQHGIRLDYRPLGQPHYGG
+IVERIIGTAMQMIHDELPGTTFSNPDQRGDYDSENKAALTLRELERWLTLAVGTYHGSVH
+NGLLQPPAARWAEAVARVGVPAVVTRATSFLVDFLPILRRTLTRTGFVIDHIHYYADGHC
+C
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF13518> PF13518</a>
+<p align="justify">Helix-turn-helix domain<br>This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF00665> PF00665</a>
+<p align="justify">Integrase core domain<br>Integrase mediates integration of a DNA copy of the viral genome into the host chromosome.  Integrase is composed of three domains.  The amino-terminal domain is a zinc binding domain Pfam:PF02022.  This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site  . </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0219> CL0219</a>
+ <p align="justify">Ribonuclease H-like superfamily This clan includes a diverse set of nucleases that share a similar structure to Ribonuclease H. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<HR SIZE=3 WIDTH=80%>
+<center><b>PROKKA_00016</b><br>
+</center>
+</td
+<tr></tr>
+<td bgcolor="#czb9dz">
+<pre> 
+MSDISRVKILSALMDGRAWTATELSSVANISASTASSHLSKLLDCQLITVVAQGKHRYFR
+LAGKDIAELMESMMGISLNHGVHARVSTPVHLRKARTCYDHLAGEVAVKIYDSLCQQQWI
+TENGSMITLSGIQYFHEMGIDVPSKHSRKICCACLDWSERRFHLGGYVGAALFSLYESKG
+WLTRHLGYREVTITEKGYAAFKTHFH
+
+ </pre>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td>
+<p align="left">
+<a href=http://pfam.xfam.org/family/PF12840> PF12840</a>
+<p align="justify">Helix-turn-helix domain<br>This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+<td bgcolor="#czb9dz">
+<p align="left">
+<a href=http://pfam.xfam.org/clan/CL0123> CL0123</a>
+ <p align="justify">This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif. </p>
+
+</p>
+</td>
+<tr></tr>
+<td></td>
+<tr></tr>
+</table>
+</div>
+</body>
+</html>
diff -r 000000000000 -r 68a3648c7d91 pfam_search/search
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/search	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,3 @@
+MerR
+family
+regulatory
diff -r 000000000000 -r 68a3648c7d91 pfam_search/table
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/pfam_search/table	Thu Dec 22 04:45:31 2016 -0500
@@ -0,0 +1,51 @@
+# pfam_scan.pl,  run at Fri Jun 19 13:56:11 2015
+#
+# Copyright (c) 2009 Genome Research Ltd
+# Freely distributed under the GNU 
+# General Public License
+#
+# Authors: Jaina Mistry (jaina@ebi.ac.uk), 
+#          Rob Finn (rdf@ebi.ac.uk)
+#
+# This is free software; you can redistribute it and/or modify it under
+# the terms of the GNU General Public License as published by the Free Software
+# Foundation; either version 2 of the License, or (at your option) any later version.
+# This program is distributed in the hope that it will be useful, but WITHOUT
+# ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS
+# FOR A PARTICULAR PURPOSE. See the GNU General Public License for more
+# details.
+#
+# You should have received a copy of the GNU General Public License along with
+# this program. If not, see <http://www.gnu.org/licenses/>. 
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+#      query sequence file: /home/inmare/galaxy/database/files/000/dataset_62.dat
+#     cpu number specified: 2
+#        searching against: /home/inmare/galaxy/tools/pfamScan/hmm/Pfam-A.hmm, with cut off --cut_ga
+#    resolve clan overlaps: on
+#     predict active sites: off
+# = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = =
+#
+# <seq id> <alignment start> <alignment end> <envelope start> <envelope end> <hmm acc> <hmm name> <type> <hmm start> <hmm end> <hmm length> <bit score> <E-value> <significance> <clan>
+
+PROKKA_00001      9     46      9     46 PF00376.18  MerR              Family     1    38    38     43.1   2.2e-11   1 CL0123   
+PROKKA_00001     51    113     51    113 PF09278.6   MerR-DNA-bind     Domain     1    65    65     67.9   7.2e-19   1 CL0123   
+PROKKA_00002      1    116      1    116 PF02411.10  MerT              Family     1   116   116    214.7   1.7e-64   1 No_clan  
+PROKKA_00003     25     85     25     86 PF00403.21  HMA               Domain     1    61    62     60.3   1.4e-16   1 No_clan  
+PROKKA_00004      8    121      8    123 PF03203.9   MerC              Family     1   114   116     81.1   7.4e-23   1 No_clan  
+PROKKA_00005      3     62      3     63 PF00403.21  HMA               Domain     1    61    62     37.8   1.5e-09   1 No_clan  
+PROKKA_00005    100    410     99    412 PF07992.9   Pyr_redox_2       Domain     2   199   201    140.8   4.8e-41   1 CL0063   
+PROKKA_00005    271    345    271    354 PF00070.22  Pyr_redox         Domain     1    74    80     51.6   9.3e-14   1 CL0063   
+PROKKA_00005    440    548    440    549 PF02852.17  Pyr_redox_dim     Domain     1   109   110    104.5   2.9e-30   1 No_clan  
+PROKKA_00006      4     72      4     73 PF13411.1   MerR_1            Family     1    68    69     44.0   1.3e-11   1 CL0123   
+PROKKA_00007      2     74      1     75 PF05052.7   MerE              Family     2    74    75    142.4     3e-42   1 No_clan  
+PROKKA_00008     13    218     11    219 PF00563.15  EAL               Domain     3   209   236    169.6   7.3e-50   1 No_clan  
+PROKKA_00009     26     78     26     87 PF13518.1   HTH_28            Domain     1    46    52     26.9   3.4e-06   1 CL0123   
+PROKKA_00009    173    313    172    313 PF00665.21  rve               Domain     2   120   120     85.4   2.9e-24   1 CL0219   
+PROKKA_00010     75    212     73    213 PF13610.1   DDE_Tnp_IS240     Domain     4   139   140    170.7   1.6e-50   1 CL0219   
+PROKKA_00011      3     40      3     41 PF00126.22  HTH_1             Domain     1    38    60     48.8   4.1e-13   1 CL0123   
+PROKKA_00013      2    366      1    366 PF03616.9   Glt_symporter     Family     2   368   368    544.8  6.1e-164   1 CL0064   
+PROKKA_00014      1     76      1     77 PF03992.11  ABM               Domain     1    77    78     48.0   8.8e-13   1 CL0032   
+PROKKA_00015     78     98     74    115 PF01842.20  ACT               Domain     9    29    66     20.5   0.00024   1 CL0070   
+PROKKA_00016      5     55      1     55 PF12840.2   HTH_20            Domain    11    61    61     35.6   5.6e-09   1 CL0123   
+PROKKA_00017     10     55      9     55 PF00440.18  TetR_N            Domain     2    47    47     53.5   1.3e-14   1 CL0123   
+PROKKA_00017     68    201     68    201 PF02909.12  TetR_C            Domain     1   139   139    165.1   6.5e-49   1 CL0174